bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells
Authors: Chang Betty Y , Huang Min Mei , Francesco Michelle , Chen Jun , Sokolove Jeremy , Magadala Padmaja , Robinson William H , Buggy Joseph J 
Published: July 2011

Abstract
Introduction
The aim was to determine the effect of the Bruton tyrosine kinase (Btk)-selective inhibitor PCI-32765, currently in Phase I/II studies in lymphoma trials, in arthritis and immune-complex (IC) based animal models and describe the underlying cellular mechanisms.

Methods
PCI-32765 was administered in a series of murine IC disease models including collagen-induced arthritis (CIA), collagen antibody-induced arthritis (CAIA), reversed passive anaphylactic reaction (RPA), and passive cutaneous anaphylaxis (PCA). Clinical and pathologic features characteristic of each model were examined following treatment. PCI-32765 was then examined in assays using immune cells relevant to the pathogenesis of arthritis, and where Btk is thought to play a functional role. These included proliferation and calcium mobilization in B cells, cytokine and chemokine production in monocytes/macrophages, degranulation of mast cells and its subsequent cytokine/chemokine production.

Results
PCI-32765 dose-dependently and potently reversed arthritic inflammation in a therapeutic CIA model with an ED50 of 2.6 mg/kg/day. PCI-32765 also prevented clinical arthritis in CAIA models. In both models, infiltration of monocytes and macrophages into the synovium was completely inhibited and importantly, the bone and cartilage integrity of the joints were preserved. PCI-32765 reduced inflammation in the Arthus and PCA assays. In vitro, PCI-32765 inhibited BCR-activated primary B cell proliferation (IC50 = 8 nM). Following FcγR stimulation, PCI-32765 inhibited TNFα, IL-1β and IL-6 production in primary monocytes (IC50 = 2.6, 0.5, 3.9 nM, respectively). Following FcεRI stimulation of cultured human mast cells, PCI-32765 inhibited release of histamine, PGD2, TNF-α, IL-8 and MCP-1.

Conclusions
PCI-32765 is efficacious in CIA, and in IC models that do not depend upon autoantibody production from B cells. Thus PCI-32765 targets not only B lymphocytes but also monocytes, macrophages and mast cells, which are important Btk-expressing effector cells in arthritis.
Prevalences of overweight, obesity, hyperglycaemia, hypertension and dyslipidaemia in the Gulf: systematic review
Authors: Alhyas Layla , Mckay Ailsa , Balasanthiran Anjali , Majeed Azeem 
Published: July 2011

Objectives To examine the prevalence of risk factors for diabetes and its complications in the Co-operation Council of the Arab States of the Gulf (GCC) region. Design Systematic review. Setting Co-operation Council of the Arab States of the Gulf (GCC) states (United Arab Emirates, Bahrain, Saudi Arabia, Oman, Qatar, Kuwait). Participants Residents of the GCC states participating in studies on the prevalence of overweight and obesity, hyperglycaemia, hypertension and dyslipidaemia. Main outcome measures Prevalences of overweight, obesity and hyperglycaemia, hypertension and hyperlipidaemia. Results Forty-five studies were included in the review. Reported prevalences of overweight and obesity in adults were 25–50% and 13–50%, respectively. Prevalence appeared higher in women and to hold a non-linear association with age. Current prevalence of impaired glucose tolerance was estimated to be 10–20%. Prevalence appears to have been increasing in recent years. Estimated prevalences of hypertension and dyslipidaemia were few and used varied definitions of abnormality, making review difficult, but these also appeared to be high and increasing, Conclusions There are high prevalences of risk factors for diabetes and diabetic complications in the GCC region, indicative that their current management is suboptimal. Enhanced management will be critical if escalation of diabetes-related problems is to be averted as industrialization, urbanization and changing population demographics continue.
Assessment of the White-Coat Effect Among Hypertensive Patients Presumed to Be at Goal
Authors: Bookstaver David A , Hatzigeorgiou Christos 
Published: July 2011

Background: There are limited studies that explore the rate of existent uncontrolled hypertension versus a significant white-coat effect. Likewise, few studies have described the physician's response to the results of an ambulatory blood pressure monitoring (ABPM) study. Objective: To determine the percentage of treated hypertensive patients referred for ABPM based on discrepant office and home blood pressures who had achieved goal blood pressure and to determine the degree of white-coat effect in these patients. Methods: Medical records of 222 consecutive patients were reviewed. Patients without a clinic visit since a medication change and those with <70% valid readings on ABPM were excluded. The proportion of patients at their goal blood pressure during ABPM was determined. Clinic blood pressure readings prior to ABPM were compared to daytime ABPM readings to calculate the white-coat effect. The percentage of patients whose blood pressure decreased by 10% or more in the night interval versus the daytime period was calculated. Changes to antihypertensive therapy were determined for the 6-month post-ABPM period. Results: One hundred ninety-three patients met the inclusion criteria. Mean (SD) clinic blood pressure was 158/77 (13/10) mm Hg, compared to mean daytime ABPM readings of 127/70 (12/9) mm Hg. Sixty-seven percent of patients were at goal blood pressure. The mean white-coat effect was 31/7 (16/9) mm Hg and was significantly greater in patients who were at goal versus those who were not (p < 0.01). A 10% or higher overnight dip occurred in 28% of those at goal. Therapy was not escalated 6 months after ABPM in 91% of patients who were at goal during the test despite a mean post-ABPM clinic blood pressure of 151/74 mm Hg. Conclusions: The majority of patients with incongruent clinic and home blood pressure readings were at goal after ABPM evaluation. Further study is needed regarding demographic or clinical characteristics that can be used to help predict which patients may be experiencing a significant white-coat effect and are actually at goal in an ambulatory setting.
Microevolution of Bechstein's Bat Myotis Bechsteinii (Kuhl, 1817) (Mammalia: Chiroptera) in the Holocene of Southern Poland
Authors: Stanik Katarzyna , Wołoszyn Bronisław 
Published: July 2011

Microevolution of Bechstein's Bat Myotis Bechsteinii (Kuhl, 1817) (Mammalia: Chiroptera) in the Holocene of Southern Poland
Bechstein's bat was one of the most common species in the Middle and Late Holocene of Southern Poland. It dominated in Kraków - Częstochowa Upland, but was also frequent in Tatra Mountains. Bone material from thanatocoenoses, dated by 14C AMS method, was analysed. The aim of studies was to investigate the direction of changes in skull and mandible morphology of Myotis bechsteinii during the period from 5710 BC till present day and to answer the question which environmental parameters significantly correlates with these microevolutionary processes and frequency of species in different thanatocoenoses. Mandibles and skulls were analysed separately. Morphology was correlated with climate characteristics, temperatures, and percentage pollen of such species of trees as hornbeam (Carpinus betulus), beech (Fagus sylvatica), oak (Quercus) and elm (Ulmus) in investigated time limits.
Cross-cultural Adaptation of VISA-P Score for Patellar Tendinopathy in Spanish Population
Authors: Hernandez-Sanchez Sergio , Hidalgo Maria Dolores , Gomez Antonia 
Published: July 2011

Study Design Clinical measurement. Objectives To adapt the VISA-P questionnaire into Spanish and to assess its psychometric properties. Background Health status questionnaires and scales to report outcomes are increasingly used in medical research and clinical practice. Validated versions of these tools are necessary to avoid bias during use in different languages and cultures. Methods We followed international recommendations to perform cross-cultural adaptation. The Spanish VISA-P (VISA-P-Sp) questionnaire and the Short Form (36) Health Survey (SF-36) were administered to 150 individuals: 40 healthy students, 40 professional players in sports requiring jumping, 40 athletes with patellar tendinopathy, and 30 athletes with knee injuries other than patellar tendinopathy. Participants were assessed at baseline and after 1 week. Athletes with tendinopathy also completed questionnaires and other knee measures (the Kujala Scoring Questionnaire and the Cincinnati Knee Rating Scale) after physiotherapy treatment, which consisted of rest, ice, eccentric exercise, electrotherapy, and manual therapy. Results The VISA-P-Sp showed high reliability for both temporal stability (intraclass correlation coefficient [ICC] = 0.994; 95% CI: 0.992, 0.996) and internal consistency (Cronbach α = 0.885). Based on a factor analysis, a 2-factor solution explained 76.1% of the variance. The VISA-P-Sp score in the tendinopathy group was significantly correlated with scores on other knee scales (Kujala score [Spearman rho = 0.897; P<.001] and Cincinnati scale [Spearman rho = 0.782, P<.001]) and with SF-36 physical components score (Spearman rho>0.6, P<.001). The standardized size effect was 1.14, and the standardized response mean was 1.17. Conclusion The VISA-P-Sp questionnaire proved to be a valid and reliable instrument, sensitive to clinical changes and comparable to the original English-language version. J Orthop Sports Phys Ther 2011;41(8):581–591, Epub 12 July 2011. doi:10.2519/jospt.2011.3613
Temporal patterns of soil phosphorus release to runoff during a rainfall event as influenced by soil properties and its effects on estimating soil P losses
Authors: Wang Y. T. , Zhang T. Q. , Hu Q. C. , O'Halloran I. P. , Tan C. S. , Reid K. 
Published: July 2011

Wang, Y. T., Zhang, T. Q., Hu, Q. C., O'Halloran, I. P., Tan, C. S. and Reid, K. 2011. Temporal patterns of soil phosphorus release to runoff during a rainfall event as influenced by soil properties and its effects on estimating soil P losses. Can. J. Soil Sci. 91: 339–347. The phosphorus (P) released in soil runoff during a rainfall event varies as labile P is depleted, and the dynamic pattern can be a function of soil P content and other soil properties. This study was conducted to determine the temporal pattern of runoff dissolved reactive P (DRP) concentration during a simulated rainfall event and the controlling soil properties. Soil samples were collected from six soil types across the province of Ontario, with 10 sites for each, to provide a wide range of soil test P (STP) levels. The instantaneous DRP concentration in surface runoff created during the rainfall event could be predicted by time t (min, since the onset of surface runoff) through a power function: DRP=αt−β, where α and β are constants representing initial potential of soil P release to runoff as DRP at the onset of surface runoff and DRP decrease rate with time, respectively. The values of α and β for a given soil could be determined by DPSM3-2 (Mehlich-3 P/Mehlich-3 Al) using the following formulas:[Formula: see text] The description of the temporal pattern of runoff DRP concentration during a rainfall event with the constants estimated using DPSM3−2 can aid in the prediction of soil runoff DRP loss.
Effect of Different Polishing Agents on Surface Finish and Hardness of Denture Base Acrylic Resins: A Comparative Study
Authors: Srividya S , Nair Chandrasekharan K , Shetty Jayakar 
Published: July 2011

ABSTRACT
Polished dentures obtained from the laboratory require adjustment during insertion. A smooth surface on acrylic resin can be obtained using a chairside protocol for polishing using silicone polishing agents and polishing media. The aim of this paper is to study the effect of three different polishing agents-pumice, universal polishing paste and Brite-O on the surface finish and hardness of two types of denture base acrylic resins-auto polymerizing and heat-activated acrylic resin materials.
Overdenture Abutments under a Fixed Partial Denture: Case Report of a Preventive Prosthodontic Approach
Authors: Singh Saumyendra , Talwar Naina , Mishra Niraj , Chand Pooran 
Published: July 2011

ABSTRACT
The use of overdenture abutments under removable partial dentures to preserve alveolar bone and provide support is well established, but there is little evidence of their use under fixed partial dentures. There exist a variety of clinical situations in which teeth or roots with questionable prognosis cannot be utilized as abutments for fixed partial dentures. In such situations these teeth/roots can be preserved under fixed prosthesis to provide vertical support and delay bone loss. The following report describes technical considerations, advantages and limitations of this treatment modality.
Comparing Isoelectric Point and Surface Composition of Plasma Modified Native and Deposited SiO2 Films Using Contact Angle Titrations and X‐ray Photoelectron Spectroscopy
Authors: Trevino Kristina J. , Shearer Jeffrey C. , Tompkins Brendan D. , Fisher Ellen R. 
Published: July 2011

AbstractSurface isoelectric point, contact angle (CA), chemical composition, film growth method, and aging effects were measured for plasma‐surface treatment of two different types of SiO2 substrates. The relationship between these values was explored using X‐ray photoelectron spectroscopy and CA titrations. Two plasma systems, Ar and H2O vapor inductively coupled rf plasmas were used to induce hydrophilic surface modifications on the SiO2 substrates. The SiO2 films deposited from a hexamethylsiloxane/O2 plasma were less susceptible to aging effects after plasma treatment than the native oxide layers. The stability of these surfaces is attributed to their relative thickness and mild annealing experienced during film formation.magnified image
SEMIGLOBAL EXTENSION OF MAXIMALLY COMPLEX SUBMANIFOLDS
Authors: DELLA SALA GIUSEPPE , SARACCO ALBERTO 
Published: July 2011

AbstractLet A be a domain of the boundary of a (weakly) pseudoconvex domain Ω of ℂn and M a smooth, closed, maximally complex submanifold of A. We find a subdomain E of ℂn, depending only on Ω and A, and a complex variety W⊂E such that bW=M in E. Moreover, a generalization to analytic sets of depth at least 4 is given.
On the determination of the ramification index in Clifford's theorem
Authors: van der Waall Robert W. 
Published: July 2011

Let K be a field, G a finite group, V a (right) KG-module. If H is a subgroup of G, then, restricting the action of G on V to H, V is also a KH-module. Notation: VH.Suppose N is a normal subgroup of G. The KN-module VN is not irreducible in general, even when V is irreducible as KG-module. A part of the well-known theorem of A. H. Clifford [1, V.17.3] yields the following.
Antitumor Activity of a Recombinant Soluble Ectodomain of Mutant Human Fibroblast Growth Factor Receptor-2 IIIc
Authors: Wang Ju , Liu Xue-ting , Huang Hui , Xiao Gang , Zhou Zhi-you , Chen Yang , Yu Zhi-hong , He Shui-lian , Chen An-an , Wang Ding-ding , He Ying , Zhang Zhi-cheng , Hong An 
Published: July 2011

Abstract
The fibroblast growth factor (FGF) signaling pathway is a recognized target of cancer therapy. We have developed a strong inhibitor (S252W mutant soluble ectodomain of FGF recptor-2 IIIc, msFGFR2) that binds FGFs and blocks the activation of FGFRs. Thermodynamic binding studies indicated that msFGFR2 bound FGF-2 16.9 times as strongly as wild-type soluble FGFR2IIIc ectodomain (wsFGFR2). It successfully suppressed the growth, angiogenesis, and metastasis of two tumor cell lines in vitro and in vivo, and it potently inhibited cancer cell proliferation but not normal cell proliferation. Therefore, msFGFR2 is a useful probe for FGF-dependent signaling pathways and a potential broad-spectrum antitumor agent. Mol Cancer Ther; 10(9); 1656–66. ©2011 AACR.
Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients
Authors: Park Sung Taek , Song Min Jong , Park Jong Sup , Hur Soo Young , Lee Chung Won 
Published: July 2011

Abstract

Background
Renal allograft recipients are reported to have a higher incidence of malignancy than the general population. This single hospital-based study examined the incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients.

Methods
Among 453 women receiving renal transplantation from January 1990 to December 2008, 5 patients were diagnosed with cervical carcinoma. Medical records of these 5 patients were retrospectively reviewed, and clinicopathologic data were collected and analyzed.

Results
The incidence of cervical carcinoma in renal transplant recipients was 58.1 out of 100,000 per year, which is 3.5 times higher than in the general Korean population. The mean interval between the time of renal transplantation and the time of cervical carcinoma diagnosis was 80.7 months. After a median follow-up of 96.2 months, there was no recurrence of the disease or death. In 4 patients who were positive from human papillomavirus in situ hybridization (HPV ISH), high or probably high risk HPV DNA was detected in all. Punctate staining of HPV ISH was detected in 3 out of 4 patients.

Conclusions
Higher incidence of cervical carcinoma is expected in renal transplant recipients, so appropriate surveillance is needed to ensure early detection and treatment of cervical carcinoma.
TDM-Guided Therapy with Daptomycin and Meropenem in a Morbidly Obese, Critically Ill Patient
Authors: Pea Federico , Cojutti Piergiorgio , Sbrojavacca Rodolfo , Cadeo Barbara , Cristini Francesco , Bulfoni Alessandro , Furlanut Mario 
Published: July 2011

Objective: To describe a case of severe cellulitis, successfully treated with high-dose daptomycin plus continuous infusion meropenem, in a patient with morbid obesity and renal failure, in whom drug exposure over time was optimized by means of realtime therapeutic drug monitoring (TDM). Case Summary: A 63-year-old man with morbid obesity (body mass index 81.6 kg/m2) and renal failure was admitted to the emergency department because of severe cellulitis. The patient had an admission Laboratory Risk Indicator for Necrotizing Fasciitis score of 9, and broad-spectrum antimicrobial therapy with daptomycin and meropenem was started. Because of rapidly changing renal function, dosage adjustments were guided by an intensive program of TDM (daptomycin ranging from 1200 mg every 48 hours over 30 minutes to 1200 mg every 36 hours over 30 minutes; meropenem ranging from 0.25 g every 8 hours over 6 hours to 500 mg every 4 hours by continuous infusion). Clinical response was observed within 72 hours. However, a sudden increase of serum creatine kinase (SCK) raised questions about the need for discontinuation of daptomycin. The drug concentrations were not toxic; therefore, we decided to continue therapy. Significant clinical improvement, with SCK normalization, was observed within a few days. Antimicrobial therapy was switched on day 29 to amoxicillin/clavulanate plus levofloxacin, and then discontinued at discharge on day 53. Discussion: High-dose daptomycin plus continuous infusion meropenem may ensure adequate empiric antimicrobial coverage in patients with possible early necrotizing fasciitis. However, in patients with morbid obesity and changing renal function, significant challenges may arise because of the hydrophilic nature of these drugs and the inaccuracy of standard methods of estimating renal function. Conclusions: Real-time TDM may represent an invaluable approach in optimizing drug exposure with high-dose daptomycin plus continuous infusion meropenem in patients with severe cellulitis, morbid obesity, and changing renal function.
Patients with neovascular age-related macular degeneration in Spain display a high cardiovascular risk
Authors: Olea Jose Luis , Tuñón José 
Published: July 2011

Purpose Cardiovascular disease and its risk factors may have a significant role in the development of neovascular age-related macular degeneration (NV-AMD). This study aims to assess the impact of these factors in this population and define their level of cardiovascular risk according to the Framingham model. Methods This was a cross-sectional, observational, multicenter study that included patients aged 50 years or older who attended ophthalmic centers for the diagnosis or follow-up of NV-AMD. Information collected included demographic and AMD data, a complete history of cardiovascular disease and its risk factors, lipid profile, blood pressure, and treatment history. Results The study population consisted of 901 patients, predominantly Caucasian, with a mean age of 75.7 years, receiving anti–vascular endothelial growth factor therapy for their NV-AMD in 77.7% of the cases. Blood pressure measurement during the study visit and lipid analyses revealed poor control in 67.7% and 93.3% of the patients, respectively. Hypertension was the most prevalent cardiovascular risk factor (77.7%), followed by a history of cardiac disease or other forms of atherosclerotic disease (53.8%). Diabetes was present in 28% of the subjects. The study population was considered a high-risk population according to the National Cholesterol Education Program Expert Panel Clinical Guidelines (NCEP ATP III), with a probability of a cardiovascular event in 10 years of 19.3% according to the Framingham model. Conclusions This NV-AMD population is associated with a significant cardiovascular risk, and the Framingham model can help us identify those subjects with higher risk levels in order to improve their overall management.
Cholesterol 25‐Hydroxylase Protects Against Diabetic Kidney Disease by Regulating ADP Ribosylation Factor 4
Authors: Zhang Lu , Fang Zhengying , Zhu Qingqing , Yang Shumin , Fu Jia , Sun Zeguo , Lu Geming , Wei Chengguo , Zhang Zhi , Lee Kyung , Zhong Yifei , Liu Ruijie , He John Cijiang 
Published: May 2024

AbstractCholesterol 25‐hydroxylase (CH25H), an enzyme involved in cholesterol metabolism, regulates inflammatory responses and lipid metabolism. However, its role in kidney disease is not known. The author found that CH25H transcript is expressed mostly in glomerular and peritubular endothelial cells and that its expression increased in human and mouse diabetic kidneys. Global deletion of Ch25h in Leprdb/db mice aggravated diabetic kidney disease (DKD), which is associated with increased endothelial cell apoptosis. Treatment of 25‐hydroxycholesterol (25‐HC), the product of CH25H, alleviated kidney injury in Leprdb/db mice. Mechanistically, 25‐HC binds to GTP‐binding protein ADP‐ribosylation factor 4 (ARF4), an essential protein required for maintaining protein transport in the Golgi apparatus. Interestingly, ARF4's GTPase‐activating protein ASAP1 is also predominantly expressed in endothelial cells and its expression increased in DKD. Suppression of ARF4 activity by deleting ARF4 or overexpressing ASAP1 results in endothelial cell death. These results indicate that 25‐HC binds ARF4 to inhibit its interaction with ASAP1, and thereby resulting in enhanced ARF4 activity to confer renoprotection. Therefore, treatment of 25‐HC improves kidney injury in DKD in part by restoring ARF4 activity to maintain endothelial cell survival. This study provides a novel mechanism and a potential new therapy for DKD.