bluuebunny/crossref_metadata_2025_split huggingface dataset:
Profiling changes in gait dynamics resulting from progressive 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine‐induced nigrostriatal lesioning
Authors: Goldberg Natalie R.S. , Hampton Tom , McCue Scott , Kale Ajit , Meshul Charles K. 
Published: July 2011

AbstractCurrent behavioral measurements for motor impairment are not consistently sensitive in rodent models of partial nigrostriatal dopamine (DA) depletion. In addition to exploratory and somatosensory behavior, motor skills that are thought to be directly translatable to human Parkinson's disease patients are assessed. However, many of these motor tests require the training and learning of particular tasks, so it cannot be determined whether impairments are due to motor or to learning deficit. Therefore, we have quantified multiple temporal and spatial indices of gait dynamics in a model of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced partial nigrostriatal lesioning using a treadmill apparatus requiring no prior training. Three days following the cessation of progressively increased MPTP administration, rearing and foot‐fault behaviors showed significant deficit. Ten days after the final MPTP injection, gait dynamics were assessed and indicated differences between MPTP‐ and vehicle‐treated animals. The major significant changes were in stride length, frequency, duration, and number of steps. Three weeks following a progressively increased dose of MPTP (administered 5 days per week over the course of 4 weeks), mice showed a 63% decrease in tyrosine hydroxylase‐immunoreactive (TH‐ir) nigrostriatal neurons in the substantia nigra pars compacta and a 72% decrease in TH‐ir terminals in the caudate‐putamen. This suggests that there is a continued effect of progressively increased MPTP on nigrostriatal DA neurons, correlated with rearing and foot‐fault behaviors and further characterized by differences in temporal and spatial measurements of gait dynamics. © 2011 Wiley‐Liss, Inc.
Effects of FK506 and cyclosporin a on calcium ionophore‐induced mitochondrial depolarization and cytosolic calcium in astrocytes and neurons
Authors: Kahraman Sibel , Bambrick Linda L. , Fiskum Gary 
Published: July 2011

AbstractThis study tested the hypothesis that sensitivity to the Ca2+‐induced loss of mitochondrial membrane potential (ΔΨm) and the sensitivity of the loss of ΔΨ to mitochondrial permeability transition pore (PTP) inhibitors are different for neurons and astrocytes. Primary cultures of rat cortical neurons and astrocytes were exposed to the Ca2+ ionophore 4‐Br‐A23187, and ΔΨm was monitored with the fluorescent probe tetramethylrhodamine methyl ester (TMRM). Ca2+ ionophore caused a decline in ΔΨm in both cell types that was partially inhibited by cyclosporin A (CsA) in astrocytes but not in neurons. Another PTP inhibitor, 2‐aminoethoxy‐diphenylborate, was ineffective at protecting against mitochondrial depolarization, but depolarization was inhibited by FK506, an immunosuppressant drug similar to CsA that does not inhibit the PTP. CsA and FK506 both significantly reduced the ionophore‐induced rise in [Ca2+]i in both neurons and astrocytes. We conclude that the protective effects of CsA and FK506 against Ca2+ ionophore‐induced mitochondrial membrane depolarization in intact astrocytes is not due to PTP inhibition but possibly is a consequence of inhibiting the rise in [Ca2+]i. © 2011 Wiley‐Liss, Inc.
Effects of age and platelet‐rich plasma on ACL cell viability and collagen gene expression
Authors: Cheng Mingyu , Johnson Victor M. , Murray Martha M. 
Published: July 2011

AbstractPlatelet‐rich plasma (PRP) has shown in vivo potential to stimulate anterior cruciate ligament (ACL) healing at early time points in large animal models. However, in animal models, the healing potential of the ACL is dependent on animal age. In this study, we hypothesized that there are age‐dependent differences in ACL cell metabolism, collagen gene expression, and the ability of the cells to respond to growth factors in PRP. To test this hypothesis, ACL cells were obtained from skeletally immature, adolescent and adult pigs, and cultured in a collagen type I hydrogel with or without PRP for 14 days. When cultured in collagen‐only hydrogel, ACL cells from adult pigs had a 19% lower apoptotic rate as compared to immature pigs (p = 0.001) and a 25% higher cellular metabolic activity as compared to adolescent pigs (p = 0.006). The addition of PRP to the collagen hydrogel resulted in a significantly increased cellular metabolic activity, reduced apoptotic rate, and stimulation of collagen production in the cells from the immature and adolescent animals (p < 0.05 for all comparisons) but had less effect on adult cells. These findings suggest that skeletal maturity may influence ACL cells' metabolic activity, apoptosis, collagen production, and response to PRP. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:79–85, 2012
Effect of anterior cruciate healing on the uninjured ligament insertion site
Authors: Haus Brian M. , Mastrangelo Ashley N. , Murray Martha M. 
Published: July 2011

AbstractThe effect of anterior cruciate healing on the uninjured ligament insertion site after enhanced suture repair with collagen‐platelet composites (CPC) has not yet been defined. In this study, we hypothesized that fibroblasts and osteoclasts would participate in generating histologic changes in insertion site morphology after transection and bioenhanced repair of the ACL, and that these changes would be age‐dependent. Skeletally immature, adolescent, and adult Yucatan mini‐pigs underwent ACL transection and bioenhanced suture repair. The histologic response to repair of the insertion site was evaluated at 1, 2, 4, and 15 weeks. In young and adolescent animals treated with bioenhanced suture repair with CPC, changes in the insertion site included: (1) fibroblastic proliferation with loss and return of collagen alignment in the fibrous zone; (2) osteoclastic resorption within fibrocartilage zones at 2–4 weeks; and (3) partial reappearance of fibrocartilage zones at 15 weeks. In adult animals; however, degenerative changes were noted by 15 weeks: (1) loss of parallel arrangement of collagen fibers in the fibrous zone; and (2) increasing disorganization and loss of columnation of chondrocytes in the fibrocartilage zone. These results suggest that fibroblasts and osteoclasts mediate histologic changes at the insertion site during bioenhanced suture repair of the ACL which may prevent insertion site degeneration, and that the magnitude of these changes may be a function of skeletal maturity. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:86–94, 2012
Evaluating the toxic and beneficial effects of jering beans (Archidendron jiringa) in normal and diabetic rats
Authors: Shukri Radhiah , Mohamed Suhaila , Mustapha Noordin Mohamed , Hamid Azizah Abdul 
Published: July 2011

AbstractBACKGROUND: Jering (Archidendron jiringa) is eaten in the tropics and traditionally extolled for treating diabetes, high blood pressure and eliminating bladder stones. Jering contains an unusual amino acid—djenkolic acid (S,S′‐methylenebiscysteine)—which may form sharp crystals in the urinary tract, causing pain and haematuria. This study evaluates the beneficial and toxic effects of dietary jering on tissues and organs in normal and diabetic rats.RESULTS: Dietary jering administered orally to diabetic rats significantly reduced the blood glucose in the streptozotocin‐induced diabetic rats to normal levels after about 12 weeks. Jering improved the rats' appetite, body weight, organ oxidative status and number of active islets of Langerhans in both diabetic and normal rats, after 15 weeks of treatment. Although dietary jering showed beneficial effects to diabetic eye lens, lung and pancreas, it caused hypertrophy and lesions to the heart, kidney, liver, lung and pancreas of normal rats.CONCLUSION: Chronic jering consumption showed toxic effects to the heart, kidney, liver and pancreas of normal rats but produced some beneficial effects to diabetic rats. Copyright © 2011 Society of Chemical Industry
Volatile fraction composition and physicochemical parameters as tools for the differentiation of lemon blossom honey and orange blossom honey
Authors: Kadar Melinda , Juan‐Borrás Marisol , Carot Jose M , Domenech Eva , Escriche Isabel 
Published: July 2011

AbstractBACKGROUND: Volatile fraction profile and physicochemical parameters were studied with the aim of evaluating their effectiveness for the differentiation between lemon blossom honey (Citrus limon L.) and orange blossom honey (Citrus spp.). They would be useful complementary tools to the traditional analysis based on the percentage of pollen.RESULTS: A stepwise discriminant analysis constructed using 37 volatile compounds (extracted by purge and trap and analysed by gas chromatography–mass spectrometry), and physicochemical and colour parameters (diastase, conductivity, Pfund colour and CIE L*a*b*) together provided a model that permitted the correct classification of 98.3% of the original and 96.6% of the cross‐validated cases, indicating its efficiency and robustness. This model proved its effectiveness in the differentiation of both types of honey with another set of batches from the following year.CONCLUSION: This model, developed from the volatile compounds, physicochemical and colour parameters, has been useful for the differentiation of lemon and orange blossom honeys. Furthermore, it may be of particular interest for the attainment of a suitable classification of orange honey in which the pollen count is very low. These capabilities imply an evident marketing advantage for the beekeeping sector, since lemon blossom honey could be commercialized as unifloral honey and not as generic citrus honey and orange blossom honey could be correctly characterized. Copyright © 2011 Society of Chemical Industry
Continuous hydrolysis of modified wheat gluten in an enzymatic membrane reactor
Authors: Cui Jie , Kong Xiangzhen , Hua Yufei , Zhou Huiming , Liu Qing 
Published: July 2011

AbstractBACKGROUND: The low solubility of wheat gluten is one of the major limitations to its use in food processing, and enzymatic hydrolysis has been found to be an effective way to prepare more soluble bioactive peptides from gluten. The aim of this study was to prepare bioactive peptides from modified wheat gluten (MWG) in a continuous enzymatic membrane reactor (EMR) that allowed rapid separation of low‐molecular‐weight peptides from hydrolysates, thus avoiding the disadvantages of batch reaction such as inefficient use of enzymes, inconsistent products due to batch‐to‐batch variation, substrate–product inhibition, low productivity and excessive hydrolysis.RESULTS: Wheat gluten was modified to decrease its lipid and starch contents in order to prevent membrane fouling. The optimal working conditions for Alcalase to hydrolyse MWG in the EMR were a substrate concentration of 20 g L−1, an enzyme/substrate ratio of 0.03, an operating pressure of 0.04 MPa, a temperature of 40 °C and a pH of 9. The operating stability of the EMR (including residual enzyme activity, productivity and capacity) was high. The permeate fractions showed antioxidant activities that were mostly due to low‐molecular‐weight peptides. A simple theoretical kinetic model was successfully applied to the enzymatic hydrolysis of MWG in the EMR.CONCLUSION: Modification of wheat gluten made the continuous enzymatic membrane reaction more efficient and the EMR proved to be an effective means of producing peptides with particular properties and bioactivities. The permeate fractions (mainly < 1000 Da) were homogeneous and stable and also showed strong antioxidant activities. Copyright © 2011 Society of Chemical Industry
Determination of luteolin and apigenin in celery using ultrasonic‐assisted extraction based on aqueous solution of ionic liquid coupled with HPLC quantification
Authors: Han Dandan , Row Kyung Ho 
Published: July 2011

AbstractBACKGROUND: Ionic liquids are a class of organic salts with melting points equal to or below 100 °C, and their use in sample preparation has shown its promise, for example, in alleviation of environmental pollution and improvement of selectivity and extraction of certain interesting compounds.RESULTS: Optimal conditions were obtained by using 1.0 mol L−1 1‐butyl‐3‐methylimidazolium methylsulfate ([Bmim][MS]) aqueous solution at pH 1.0 as the extraction solvent. An ultrasonic power of 200 W was chosen to ensure complete dispersion of [Bmim][MS] into celery in 90 min and the solid:liquid ratio was 1:10.CONCLUSION: The proposed ultrasonic assistant extraction approach, based on ionic liquid aqueous solution, exhibited satisfactory results, with recovery values ranging from 72.7% to 89.5%. Under optimal conditions, compared with conventional solvent extraction amounts of luteolin and apigenin were more than doubled. Copyright © 2011 Society of Chemical Industry
Robustness of Distance Decay for International Pleasure Travelers: A Longitudinal Approach
Authors: Lee Hee ‘Andy’ , Guillet Basak Denizci , Law Rob , Leung Rosanna 
Published: July 2011

ABSTRACTDistance decay explains tourism demand in terms of destination distance from the origin. Although travelers tend to travel further over time, scant research studies have examined the relationship between temporal variant and distance decay. This study examines the relationship between distance and destination choice of Hong Kong international pleasure travelers’ activity over a decade. A constant pattern of distance decay with two secondary peaks was identified for a decade. This study suggests a threshold of a three‐hour flight for a five‐day trip before demand declined exponentially. The findings imply that the no traveling zone would result from weak pulling power. Copyright © 2011 John Wiley & Sons, Ltd.
Diodenlaserbarren in der Druckindustrie
Authors: Neukum Jörg 
Published: July 2011

AbstractDie im Offsetdruck eingesetzten Druckplatten sind häufig sogenannte Thermoplatten, welche für Licht im Bereich von 810 nm – 830 nm sensitiv sind. Durch fotochemische Reaktionen der Beschichtung kann mit Licht die Eigenschaft der Druckplatte, Farbe anzunehmen, punktuell gesteuert werden. Für die Belichtung solcher Thermoplatten haben sich Hochleistungslaserdioden durchgesetzt, welche entweder als fasergekoppelte Single‐Emitter, als strahlgeformter Diodenlaserbarren, oder als Laserdiodenarray mit einzeln ansteuerbaren Emittern zum Einsatz kommen. Dadurch lassen sich digitale Bilder und Texte sehr schnell auf die Druckplatte übertragen (CtP, Computer‐to‐Plate). Man kann die für das Drucken benötigten Druckplatten nacheinander für die verschiedenen zu druckenden Farben belichten, oder aber – um Zeit zu sparen – eine Belichtungseinheit pro Farblaufwerk auf einer Druckmaschine integrieren (DoP, Direct‐on‐Press).
Kleinste Strukturen auf großen Flächen
Authors: Knappe Ralf , Brüning Stephan , Gillner Arnold 
Published: July 2011

AbstractPikosekundenlaser haben in den letzten Jahren im Maschinenbau Einzug gehalten und sich als zuverlässige „Plug‐and‐Play”︁‐Komponenten für die industrielle 24/7‐Produktion bewährt. Galten diese Laser früher hauptsächlich als Instrumente für den wissenschaftlichen Einsatz, so leisten heute bereits viele hundert Geräte ihren Dienst in Produktionsanlagen, mit stark steigender Tendenz.
Mit dem Laser auf Kurs
Authors: Dreher Martin 
Published: July 2011

AbstractNach wie vor stehen kleine Laserbeschrifter und Mikroschweißgeräte als Stand‐alone‐Geräte innerhalb der Fertigung. Doch die Nachfrage nach automatisierten Lösungen steigt. Dabei erweist es sich als vorteilhaft, wenn Lasermaschinenbauer und Automatisierer eng zusammenarbeiten.
Aptamers‐in‐Liposomes for Selective and Multiplexed Capture of Small Organic Compounds
Authors: Kim Yeon Seok , Niazi Javed H. , Chae Yun Ju , Ko U‐Ri , Gu Man Bock 
Published: July 2011

AbstractSmall, organic, toxic compounds are not well eliminated by water‐treatment systems and eventually become concentrated in the human body. In this study, liposomes are employed to house aptamers with their own binding buffer. When small, organic, toxic compounds in water pass through a liposome barrier, only the target molecules are captured by the DNA aptamers inside the liposomes. The capture efficiency is not high when DNA aptamers are used in tap water. When DNA aptamers in liposomes are used, the capture efficiency increases more than 80%. The simultaneous and selective elimination of target toxicants is successfully performed for tap‐water samples containing toxicant mixtures.
magnified image
Complex and magnitude‐only preprocessing of 2D and 3D BOLD fMRI data at 7 T
Authors: Barry Robert L. , Strother Stephen C. , Gore John C. 
Published: July 2011

AbstractA challenge to ultra high field functional magnetic resonance imaging is the predominance of noise associated with physiological processes unrelated to tasks of interest. This degradation in data quality may be partially reversed using a series of preprocessing algorithms designed to retrospectively estimate and remove the effects of these noise sources. However, such algorithms are routinely validated only in isolation, and thus consideration of their efficacies within realistic preprocessing pipelines and on different data sets is often overlooked. We investigate the application of eight possible combinations of three pseudo‐complementary preprocessing algorithms – phase regression, Stockwell transform filtering, and retrospective image correction – to suppress physiological noise in 2D and 3D functional data at 7 T. The performance of each preprocessing pipeline was evaluated using data‐driven metrics of reproducibility and prediction. The optimal preprocessing pipeline for both 2D and 3D functional data included phase regression, Stockwell transform filtering, and retrospective image correction. This result supports the hypothesis that a complex preprocessing pipeline is preferable to a magnitude‐only pipeline, and suggests that functional magnetic resonance imaging studies should retain complex images and externally monitor subjects' respiratory and cardiac cycles so that these supplementary data may be used to retrospectively reduce noise and enhance overall data quality. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Depression and Anxiety in Late Life: Diagnostic Insights and Therapeutic Options
Authors: Kastenschmidt Erin K. , Kennedy Gary J. 
Published: July 2011

AbstractDepression and anxiety represent a sizeable public‐health problem for older Americans. Effective treatment of depression and anxiety in late‐life patients can improve outcomes directly related to those diseases as well as to comorbid medical diseases. A variety of approaches has been shown to be effective in older adults and is easily accessible to the primary care, specialty, and inpatient practitioner. Because of the etiologic complexity associated with mood disturbance in late life, it is helpful to consider depression and anxiety in late life as a geriatric syndrome similar to frailty, falls, incontinence, and impaired cognition. These syndromes have multiple causes of associated disability, yielding a multitude of avenues for intervention. However, translating the science of care for depression and anxiety into improved mental‐health services for older adults and their families remains a challenge to providers and policy‐makers alike. In the Tables, the authors offer measures for screening and response evaluation as well as guidance for pharmacotherapy and psychotherapeutic interventions that may be incorporated into primary care. Mt Sinai J Med 78:527–545, 2011. © 2011 Mount Sinai School of Medicine
When Is It the Right Time to Ask for a Geriatrician?
Authors: Chun Audrey K. 
Published: July 2011

AbstractGiven an aging population coupled with a shortage of people to care for them, it is essential to understand the patient qualities for which geriatric expertise would be most beneficial. For the practicing physician attempting to understand the timing of geriatric‐care provision, this article reviews the relevant literature, which suggests geriatric expertise should be considered for the patients who benefit most: any patient aged ≥ 85 years, or adults aged < 85 years with complex multimorbidity, frailty, or other geriatric conditions; disability or dementia; or need for palliative or end‐of‐life care. Mt Sinai J Med 78:485–488, 2011. © 2011 Mount Sinai School of Medicine
Osteoporosis Piece of Multi‐Morbidity Puzzle in Geriatric Care
Authors: Colón‐Emeric Cathleen , O'Connell Mary Beth , Haney Elizabeth 
Published: July 2011

AbstractOsteoporosis frequently coexists with other chronic diseases and syndromes of aging, and therefore multimorbidity interactions can potentially complicate its evaluation and treatment. This article reviews osteoporosis comorbidity interactions with select common diseases of aging including cardiovascular, neurologic, and geriatric syndromes, and select commonly used medications by older adults. Using depression as a case example, we describe the complex relationship between osteoporosis, mood, and antidepressant medications, and the implications of these interactions for patients and clinicians. Mt Sinai J Med 78:515–526, 2011. © 2011 Mount Sinai School of Medicine
Palliative Care: A Primer
Authors: Litrivis Evgenia , Smith Cardinale B. 
Published: July 2011

AbstractPalliative care is a medical specialty that aims to improve the quality of life for patients with chronic and advanced serious illness and their families. It is appropriate throughout all stages of the trajectory of illness, which distinguishes it from hospice care. Hospice care is limited to patients with terminal prognoses. Palliative care practitioners provide expert symptom management, psychosocial support, and assistance with provider‐patient communication and complex decision‐making, as well as help with transitions of care. Palliative care has been associated with improved outcomes for patients and families and has experienced a rapid expansion in available services. Despite this, palliative care consultation continues to be underutilized. As the number of patients living with complex and serious illness burden continues to increase, palliative care specialists will play an important role in providing timely access to critical supportive services and the provision of high‐quality care. Mt Sinai J Med 78:627–631, 2011. © 2011 Mount Sinai School of Medicine
Coronary Heart Disease in the Elderly: Identifying Established and Subclinical Disease With Stress Testing
Authors: Sahni Sheila , Vaishnava Prashant , Darrow Bruce 
Published: July 2011

AbstractAlthough cardiovascular disease is a major cause of mortality, morbidity, and healthcare expense in the United States, diagnosis in elderly patients, especially those who are asymptomatic, can be challenging. Noninvasive testing offers an opportunity to identify these patients, but guidelines reflect uncertainty of the impact of diagnosis on long‐term outcomes. We review the role of different forms of noninvasive testing in both symptomatic and asymptomatic patients, as well as patients under consideration for elective surgery. Mt Sinai J Med 78:583–589, 2011. © 2011 Mount Sinai School of Medicine