bluuebunny/crossref_metadata_2025_split huggingface dataset:
An index for staging facial lipoatrophy and evaluation of the efficacy of the treatment with polymethylmethacrylate in HIV/AIDS patients: a pilot study
Authors: Serra M.S. , Oyafuso L.K. , Trope B.M. , Munhoz Leite O.H. , Ramos‐e‐Silva M. 
Published: July 2012

AbstractBackground  Treatment of facial lipoatrophy of HIV/AIDS patients is mandatory by law in Brazil due to its negative impact on their quality of life. The index for facial lipoatrophy (ILA) is used as one of the inclusion criteria for patient treatment.Objectives  To define a correct diagnosis and staging of facial lipoatrophy, by employing the ILA.Patients and methods  This is an observational study of a series of case reports from patients submitted to facial lipoatrophy evaluation through ILA and treated with polymethylmethacrylate (PMMA) fillers. Facial lipoatrophy was classified in grades from I to IV, corresponding to mild, moderate, severe and very severe stage, according to ILA. Response to the treatment was defined as excellent (≥91%), good (71–90%), moderate (51–70%) and insufficient (≤50%).Results  A total of 20 patients were included in this study: 18 men and two women. Median age was 49 years (35–61) and average ILA was 9.9 (7.2–16.8). Ten patients presented facial lipoatrophy grade II (moderate), 5 grade III (severe) and 5 grade IV (very severe). The average volume of PMMA used was 13 mL (5.5–22 mL). All patients showed good or excellent response, with a median of 86% (74–100%). The most typical adverse effect was local oedema but there were no late adverse effects.Conclusion  The ILA is an excellent method for evaluation of facial lipoatrophy and also for the assessment of the response to therapy. Facial filling with PMMA showed efficacy and safety in the treatment of facial lipoatrophy in HIV/AIDS patients.
Evaluation of tourists’ UV exposure in Paris
Authors: Mahé E. , Corrêa M.P. , Godin‐Beekmann S. , Haeffelin M. , Jégou F. , Saiag P. , Beauchet A. 
Published: July 2012

AbstractBackground  Ultraviolet (UV) exposure is one of the most important risk factor for skin cancers. If UV hazard has been evaluated in tropical countries or in some population – children, outdoor activities – little information is available about UV hazard in high latitude towns like Paris, considered as the most ‘charismatic city’ in the world.Objective  To evaluate UV exposure in Paris in spring, in sun and shade, in real life conditions.Methods  We evaluated erythemal UV exposure, during four sunny days in May‐June in eight Paris touristic sites during peak hours (2 days), and during two walks in touristic downtown of Paris. Measures were performed in sun and shade. UV radiation exposure was evaluated with UV index performed with a ‘Solarmeter ultraviolet index (UVI)’ and UV dose with ‘standard erythema dose’ (SED) and ‘minimal erythema dose’ (MED) calculations.Results  Despite ‘average’ UVI in sunny conditions, a 4‐h sun exposure reaches 13–20 SED and 3–10 MED according to phototype. Clouds were inefficient to protect against UV. Shade of places reduces moderately UVI (50–60%) in forecourts. Exposure during 1‐h walk reach at least one MED in real life conditions for skin phototypes I–IV.Conclusions  UV risk for tourist is quite high in spring in Paris. UVI remains high despite high cloud fraction. Shade reduces UVI, but UV protection factor is only 2–3 in large places such as Place Notre Dame and Place Charles de Gaulle. So sun protection campaigns should be proposed, and sun protective strategies could be integrated in urban planning.
Children on the Autism Spectrum: Grandmother Involvement and Family Functioning
Authors: Sullivan Alison , Winograd Greta , Verkuilen Jay , Fish Marian C. 
Published: July 2012

Background  This study investigated associations between the presence of a child with autism or Asperger’s disorder in the family, family functioning and grandmother experiences with the goal of better understanding grandparent involvement in the lives of grandchildren on the autism spectrum and their families.Methods  Mothers and grandmothers of children who were either typically developing or on the autism spectrum completed parallel forms of a grandparent involvement measure. Mothers reported on the functioning of the immediate family. Data were analysed via multilevel modelling with mother–grandmother dyads as the unit of observation.Results  Autism spectrum disorders in children were associated with more flexible family functioning, lower levels of family satisfaction, greater grandmother difficulties and more grandmother information needs.Conclusions  Participation of grandparents in diagnostic and treatment meetings and increased communication among family members may facilitate grandparent support and involvement in families with a child on the autism spectrum.
Are rocks still water‐wet in the presence of dense CO2 or H2S?
Authors: BROSETA D. , TONNET N. , SHAH V. 
Published: July 2012

AbstractThe various modes of acid gas storage in aquifers, namely structural, residual, and local capillary trapping, are effective only if the rock remains water‐wet. This paper reports an evaluation, by means of the captive‐bubble method, of the water‐wet character in presence of dense acid gases (CO2, H2S) of typical rock‐forming minerals such as mica, quartz, calcite, and of a carbonate‐rich rock sampled from the caprock of a CO2 storage reservoir in the South‐West of France. The method, which is improved from that previously implemented with similar systems by Chiquet et al. (Geofluids 2007; 7: 112), allows the advancing and receding contact angles, as well as the adhesion behavior of the acid gas on the mineral substrate, to be evaluated over a large range of temperatures (up to 140°C), pressures (up to 150 bar), and brine salinities (up to NaCl saturation) representative of various geological storage conditions. The water‐receding (or gas‐advancing) angle that controls structural and local capillary trapping is observed to be not significantly altered in the presence of dense CO2 or H2S. In contrast, some alteration of the water‐advancing (or gas‐receding) angle involved in residual trapping is observed, along with acid gas adhesion, particularly on mica. A spectacular wettability reversal is even observed with mica and liquid H2S. These results complement other recent observations on similar systems and present analogies with the wetting behavior of crude oil/brine/mineral systems, which has been thoroughly studied over the past decades. An insight is given into the interfacial forces that govern wettability in acid gas‐bearing aquifers, and the consequences for acid gas geological storage are discussed along with open questions for future work.
The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury
Authors: Susín Cristina , Morales‐Garcia Jose A. , Aguilar‐Morante Diana , Palomo Valle , Sanz‐Sancristobal Marina , Alonso‐Gil Sandra , Gil Carmen , Santos Angel , Martinez Ana , Perez‐Castillo Ana 
Published: July 2012

J. Neurochem. (2012) 122, 1193–1202.AbstractIncreased levels of glutamate causing excitotoxic damage accompany many neurological disorders. A well‐characterized model of excitotoxic damage involves administration of kainic acid (KA), which causes limbic seizure activity and subsequent neuronal death, particularly in the CA1 and CA3 areas of the hippocampus. Inhibition of the enzyme glycogen synthase kinase‐3 (GSK‐3) and cAMP levels might play an important role in neuroprotection. As intracellular cAMP levels depend, in part, on the activity of the phosphodiesterase enzymes (PDEs), these enzymes have recently emerged as potential therapeutic targets for the treatment of several diseases. In previous works, we have shown a potent anti‐inflammatory and neuroprotective effect of GSK‐3 inhibition in a model of excitotoxicity, as well as a reduction of nigrostriatal dopaminergic neuronal cell death after phosphodiesterase 7 inhibition, which leads to an increase in cAMP levels. This study was undertaken to determine whether simultaneous inhibition of GSK‐3 and PDE‐7 by a novel 5‐imino‐1,2,4‐thiadiazole compound, named VP1.14, could prevent the massive neuronal loss in the hippocampus evoked by intrahippocampal injection of KA. Here, we show that rats treated with VP1.14 showed a reduced inflammatory response after KA injection, and exhibited a significant reduction in pyramidal cell loss in the CA1 and CA3 areas of the hippocampus. Studies with hippocampal HT22 cells in vitro also showed a clear neuroprotective effect of VP1.14 and an anti‐inflammatory effect shown by a decrease in the nitrite liberation and in the expression of pro‐inflammatory cytokines by primary cultures of astrocytes treated with lipopolysaccharide.
Mitochondrial dysfunction is involved in P2X7 receptor‐mediated neuronal cell death
Authors: Nishida Kentaro , Nakatani Tsunetoshi , Ohishi Akihiro , Okuda Hiroto , Higashi Youichirou , Matsuo Takaaki , Fujimoto Sadaki , Nagasawa Kazuki 
Published: July 2012

J. Neurochem. (2012) 122, 1118–1128.AbstractP2X7 receptor (P2X7R) is known to be a ‘death receptor’ in immune cells, but its functional expression in non‐immune cells such as neurons is controversial. Here, we examined the involvement of P2X7R activation and mitochondrial dysfunction in ATP‐induced neuronal death in cultured cortical neurons. In P2X7R‐ and pannexin‐1‐expressing neuron cultures, 5 or more mM ATP or 0.1 or more mM BzATP induced neuronal death including apoptosis, and cell death was prevented by oxATP, P2X7R‐selective antagonists. ATP‐treated neurons exhibited Ca2+ entry and YO‐PRO‐1 uptake, the former being inhibited by oxATP and A438079, and the latter by oxATP and carbenoxolone, while P2X7R antagonism with oxATP, but not pannexin‐1 blocking with carbenoxolone, prevented the ATP‐induced neuronal death. The ATP treatment induced reactive oxygen species generation through activation of NADPH oxidase and activated poly(ADP‐ribose) polymerase, but both of them made no or negligible contribution to the neuronal death. Rhodamine123 efflux from neuronal mitochondria was increased by the ATP‐treatment and was inhibited by oxATP, and a mitochondrial permeability transition pore inhibitor, cyclosporine A, significantly decreased the ATP‐induced neuronal death. In ATP‐treated neurons, the cleavage of pro‐caspase‐3 was increased, and caspase inhibitors, Q‐VD‐OPh and Z‐DEVD‐FMK, inhibited the neuronal death. The cleavage of apoptosis‐inducing factor was increased, and calpain inhibitors, MDL28170 and PD151746, inhibited the neuronal death. These findings suggested that P2X7R was functionally expressed by cortical neuron cultures, and its activation‐triggered Ca2+ entry and mitochondrial dysfunction played important roles in the ATP‐induced neuronal death.
Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons
Authors: Brailoiu G. Cristina , Deliu Elena , Tica Andrei A. , Chitravanshi Vineet C. , Brailoiu Eugen 
Published: July 2012

J. Neurochem. (2012) 122, 1129–1136.AbstractUrocortin 3 (also known as stresscopin) is an endogenous ligand for the corticotropin‐releasing factor receptor 2 (CRF2). Despite predominant Gs coupling of CRF2, promiscuous coupling with other G proteins has been also associated with the activation of this receptor. As urocortin 3 has been involved in central cardiovascular regulation at hypothalamic and medullary sites, we examined its cellular effects on cardiac vagal neurons of nucleus ambiguus, a key area for the autonomic control of heart rate. Urocortin 3 (1 nM–1000 nM) induced a concentration‐dependent increase in cytosolic Ca2+ concentration that was blocked by the CRF2 antagonist K41498. In the case of two consecutive treatments with urocortin 3, the second urocortin 3‐induced Ca2+ response was reduced, indicating receptor desensitization. The effect of urocortin 3 was abolished by pre‐treatment with pertussis toxin and by inhibition of phospolipase C with U‐73122. Urocortin 3 activated Ca2+ influx via voltage‐gated P/Q‐type channels as well as Ca2+ release from endoplasmic reticulum. Urocortin 3 promoted Ca2+ release via inositol 1,4,5 trisphosphate receptors, but not ryanodine receptors. Our results indicate a novel Ca2+‐mobilizing effect of urocortin 3 in vagal pre‐ganglionic neurons of nucleus ambiguus, providing a cellular mechanism for a previously reported role for this peptide in parasympathetic cardiac regulation.
Changes in hope and health‐related quality of life in couples following acute myocardial infarction: a quantitative longitudinal study
Authors: Eriksson Monica , Asplund Kenneth , Hochwälder Jacek , Svedlund Marianne 
Published: July 2012

Scand J Caring Sci; 2013; 27; 295–302

Changes in hope and health‐related quality of life in couples following acute myocardial infarction: a quantitative longitudinal study
Background:  Acute myocardial infarction (AMI) is a life‐changing event that affects both the patient and the family and can have an influence on hope as well as HRQoL during the recovery period.Aims:  To compare self‐rated scores of hope and health‐related quality of life (HRQoL) 1, 7, 13 and 25 months, after an AMI with regard to (i) differences across time, and (ii) differences between patients and their partners.Design:  Explorative and longitudinal study.Methods:  In this nonrandomized study, Short Form 36 Health Questionnaire (SF‐36) and Herth Hope Index‐Swedish (HHI‐S) questionnaires were completed by thirteen post‐AMI patients and their partners. Data were collected on four occasions.Results:  In general, hope as well as HRQoL scores increased over time. A 2 (groups) × 4 (times) anova for mixed design showed significant changes in mental as well as in physical health over time but no significant effect of group on mental or physical health. Calculation of the minimum detectable change (MDC‐index) for HHI‐S and SF‐36 revealed that scores between data collection points were not stable.Conclusion:  Our results show that although hope and HRQoL scores increased, only a few of the changes were statistically significant. Neither HHI‐S nor SF‐36 seems to measure stable states. Changes in hope and HRQoL levels may be due to participants striving to adapt to the current situation.Relevance to clinical practice:  These results can be used in the training of nursing staff to enhance their understanding of the significance of a family‐centred approach after an AMI.
Sudden generalized lung atelectasis during thoracotomy following thoracic lavage in 3 dogs
Authors: Drynan Eleanor , Musk Gabrielle , Raisis Anthea 
Published: July 2012

AbstractObjectiveTo describe sudden onset of generalized pulmonary atelectasis following thoracic lavage in 3 dogs.Series SummaryThoracic lavage was performed following ligation of a patent ductus arteriosus in case 1, prior to closure of a large traumatic full thickness wound in the chest wall in case 2, and during investigation of an idiopathic spontaneous pneumothorax in case 3. In each case anesthesia and surgery were uneventful until thoracic lavage was performed, after which sudden generalized pulmonary atelectasis was observed. The atelectasis was visualized and was associated with oxyhemoglobin desaturation, decreased end‐tidal carbon dioxide partial pressure (ETCO2), and a marked increase in the peak inspiratory pressure (PIP) required to achieve visible lung inflation. Occlusion of the endotracheal tube and cervical trachea was directly eliminated as the cause of atelectasis in cases 1 and 2, and indirectly eliminated in case 3. Improvement in pulmonary function occurred in all cases in response to increased PIP ± positive end expiratory pressure (PEEP).New or Unique Information ProvidedGeneralized atelectasis should be considered a possible complication of thoracic lavage performed during thoracotomy. In the cases presented here, it is suspected that pre‐existing reduction in lung volume (due to inadequate ventilation, surgical compression, absorption atelectasis) was exacerbated by the addition of the lavage fluid to the thoracic cavity. This pre‐existing lung collapse is believed to have resulted in reduction of lung volume and that further reduction below the critical closing volume occurred following instillation of saline into the thorax resulting in the subsequent development of generalized atelectasis. The performance of regular arterial blood gas analyses and different ventilation protocols may have prevented the marked atelectasis that was observed in these cases.
Lecithoceridae (Lepidoptera: Gelechioidea) of New Guinea, Part VIII: A new genus Sulciolus, with descriptions of two new species
Authors: PARK Kyu‐Tek 
Published: July 2012

AbstractAs the eighth part in a series on the family Lecithoceridae (Lepidoptera: Gelechioidea) from New Guinea, Sulciolus Park, gen. nov. of the subfamily Lecithocerinae is described, based on the type species, S. pachystoma (Diakonoff), comb. nov., with two additional new species: (i) S. circulivalvae sp. nov.; and (ii) S. kaindiana sp. nov. The new genus shares with Achroa Meyrick, Onnuria Park, Hamatina Park and Scolizona Park a uniquely specialized 3rd segment of labial palpus, but it is differentiated from them by having a longitudinal furrow on the inner surface of the segment. Sulciolus abrasa (Diakonoff), S. capra (Diakonoff), S. induta (Diakonoff) and S. perspicua (Diakonoff) are newly combined, and Lecithocera sextacta Diakonoff is synonymized with S. perspicua (Diakonoff). Keys to genera related to Lecithocera and to species of the genus are given. Adults, labial palpi, wing venations and male genitalia are illustrated.
New insect host records for mites of the family Microdispidae (Acari: Heterostigmatina), with description of a new species of the genus Paramicrodispus
Authors: HAJIQANBAR Hamidreza , RAHIMINEJAD Vahid , FATHIPOUR Yaghoub 
Published: July 2012

AbstractThe mite Paramicrodispus scarabidophilus Hajiqanbar and Rahiminejad sp. nov. (Acari: Prostigmata: Microdispidae) is described and illustrated based on phoretic females recovered from Oryctes nasicornis L. (Col.: Scarabaeidae) hosts, which were collected from forests in northern Iran. It is the first record of the genus Paramicrodispus for the mite fauna of Iran. We also found Paramicrodispus crenulatus (Savulkina, 1978) associated with Lucanus ibericus Motschulsky (Col.: Lucanidae), the first report of association between beetles of the family Lucanidae and the mite family Microdispidae. Moreover, for the first time we report an association between beetles of the family Scarabaeidae and Paramicrodispus mites.
Competitive Control of an Exotic Mangrove Species: Restoration of Native Mangrove Forests by Altering Light Availability
Authors: Chen Leiyi , Peng Shaolin , Li Jing , Lin Zhenguang , Zeng Yan 
Published: July 2012

AbstractRecently, many studies have focused on the possibility of restoring mangrove ecosystems by introducing fast‐growing mangroves. However, methods for managing an exotic fast‐growing species to restore mangrove ecosystems and at the same time preventing invasion by introduced species remains unclear.Sonneratia apetalaBuch‐Ham is one example of an exotic mangrove with both high ecological value and potential risk for invasion after introduction. To investigate the possibility of reducing the potential for invasion by altering light availability, we simulated different irradiances ofS. apetalaunderstory in the greenhouse. For each irradiance treatment, three levels of competition betweenS. apetalaand native mangrovesAegiceras corniculatum(L.) were used: no competition, intraspecific competition and interspecific competition. Compared withA. corniculatum,S. apetalashowed a significantly higher growth rate for both height and biomass accumulation under full irradiation. Compared to the full irradiation treatment, the shading treatment significantly reduced the height, total biomass and biomass allocation to leaves ofS. apetalaby 61.31, 71.0, and 76.2%, respectively, whereas the growth ofA. corniculatumwas not affected. The results suggested that lowering light availability could inhibit the growth ofS. apetalaand increase the competitiveness ofA. corniculatum. Planting introduced fast‐growing mangroves at a density of approximately 2,000 plants/hm2is an effective strategy for preventing potential invasion and restoring wetland habitats. By taking advantage of the differences in shade tolerance between fast‐growing exotic mangroves and native mangroves, introduction of fast‐growing mangroves in coastal areas could have huge potential for reforesting mangrove ecosystems.
Therapeutic Effects of Selective Atrioventricular Node Vagal Stimulation in Atrial Fibrillation and Heart Failure
Authors: ZHANG YOUHUA , POPOVIĆ ZORAN B. , KUSUNOSE KENYA , MAZGALEV TODOR N. 
Published: July 2012

Therapeutic Effects of Selective AVN‐VS in AF and HF. Introduction: Atrial fibrillation (AF) and heart failure (HF) frequently coexist. We have previously demonstrated that selective atrioventricular node (AVN) vagal stimulation (AVN‐VS) can be used to control ventricular rate during AF. Due to withdrawal of vagal activity in HF, the therapeutic effects of AVN‐VS may be compromised in the combined condition of AF and HF. Accordingly, this study was designed to evaluate the therapeutic effects of AVN‐VS to control ventricular rate in AF and HF.Methods and Results: A combined model of AF and HF was created by implanting a dual chamber pacemaker in 24 dogs. A newly designed bipolar electrode was inserted into the ganglionic AVN fat pad and connected to a nerve stimulator for delivering AVN‐VS. In all dogs, HF was induced by high rate ventricular pacing at 220 bpm for 4 weeks. AF was then induced and maintained by rapid atrial pacing at 600 bpm after discontinuation of ventricular pacing. These HF + AF dogs were randomized into control (n = 9) and AVN‐VS (n = 15) groups. In the latter group, vagal stimulation (310 μs, 20 Hz, 3–7 mA) was delivered continuously for 6 months. Compared with the control, AVN‐VS had a consistent effect on ventricular rate slowing (by >50 bpm, all P < 0.001) during the entire 6‐month observation period that was associated with left ventricular functional improvement. Moreover, AVN‐VS was well tolerated by the treated animals.Conclusions: AVN‐VS achieved consistent rate slowing, which was associated with improved ventricular function in a canine AF and HF model. Thus, AVN‐VS may be a novel, effective therapeutic option in the combined condition of AF and HF. (J Cardiovasc Electrophysiol, Vol. 24, pp. 86‐91, January 2013)
Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus
Authors: Omatsu Tsutomu , Moi Meng Ling , Takasaki Tomohiko , Nakamura Shinichiro , Katakai Yuko , Tajima Shigeru , Ito Mikako , Yoshida Tomoyuki , Saito Akatsuki , Akari Hirofumi , Kurane Ichiro 
Published: July 2012

AbstractBackground  Marmosets are susceptible to dengue virus (DENV) infection. However, blood parameter data and clinical signs of DENV‐infected marmosets are limited.Methods  Blood hematological and serum biochemical values were obtained from twelve DENV‐inoculated and four mock‐infected marmosets. Additionally, body temperature and activity level were determined.Results  Five DENV‐inoculated marmosets demonstrated thrombocytopenia, nine demonstrated leucopenia, and five demonstrated an increase in the levels of AST, ALT, LDH, and BUN. Additionally, seven DENV‐inoculated marmosets demonstrated clinical signs including fever and decreases in activity. None of the four mock‐inoculated marmosets demonstrated changes in either hematological or biochemical parameters.Conclusions  Marmosets inoculated with DENV exhibited clinical signs and changes in hematological and biochemical parameters. The results suggest that blood parameter data and clinical signs could potentially be useful markers for understanding the progress of DENV infection in studies using marmosets.