bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase I Trial of Hepatic Arterial Infusion of Nanoparticle Albumin–Bound Paclitaxel: Toxicity, Pharmacokinetics, and Activity
Authors: Fu Siqing , Naing Aung , Moulder Stacy L. , Culotta Kirk S. , Madoff David C. , Ng Chaan S. , Madden Timothy L. , Falchook Gerald S. , Hong David S. , Kurzrock Razelle 
Published: May 2011

Abstract
Because liver involvement in patients with metastatic cancer has limited options and poor outcomes, we conducted a phase I study to determine the safety, activity, and pharmacokinetic characteristics of hepatic arterial infusion of nanoparticle albumin–bound paclitaxel (HAI nab-paclitaxel). Cohorts of three patients having predominant hepatic metastases received HAI nab-paclitaxel at three dose levels (180, 220, and 260 mg/m2, respectively) infused for more than 1 hour every 3 weeks (3 + 3 design). Some patients participated in comparative pharmacokinetic studies (i.v. vs. HAI), receiving their first course i.v., to determine peak concentrations and effect of first-pass hepatic extraction compared with subsequent courses administered by HAI. The highest dose level was expanded to determine the safety and activity of HAI nab-paclitaxel. Thirty-eight patients were treated. There were no dose-limiting toxicities at doses up to 260 mg/m2. Common adverse events included alopecia, fatigue, myelosuppresion, nausea, and vomiting. Three patients had stable disease for 4 or more months and 2 patients (1 of 12 with breast cancer and 1 of 1 with cervical cancer) achieved a partial response lasting for 5 and 15 months, respectively. Peak concentrations were lower (∼50%) with greater hepatic extraction of drug (∼42%) following HAI than i.v. infusion based on area under the curve comparison of drug exposure. HAI nab-paclitaxel showed partial hepatic extraction. At doses 260 mg/m2 or less given for 1 hour every 3 weeks, the treatment was well-tolerated and showed activity in advanced cancer patients with predominant liver metastases. Mol Cancer Ther; 10(7); 1300–7. ©2011 AACR.
COP35, a Cholangiocarcinoma-Binding Oligopeptide, Interacts with the Clathrin Heavy Chain Accompanied by GRP78
Authors: Kitahara Hiroe , Masumoto Junya , Parker Alan L. , Maruta Fukuto , Kubo Naoki , Shimizu Akira , Akita Noriyuki , Miwa Shiro , Kobayashi Naoya , Nakayama Jun , Miyagawa Shinichi 
Published: May 2011

Abstract
Cholangiocarcinoma (CCA) is a common carcinoma of the liver, and the majority of patients with CCA have a poor prognosis due to the lack of effective nonsurgical therapies in addition to its rapid progression and inoperability at the time of diagnosis. The development of novel nonsurgical therapeutics that efficiently target CCA could significantly improve the prognosis for patients presenting with CCA. Here, we describe the iterative production and characterization of a novel peptide, designated COP35 (CCA-binding oligopeptide 35), which binds selectively to human CCA, identified by bacteriophage biopanning using the intrahepatic CCA cell line RBE and the normal cholangiocyte cell line MMNK-1. COP35 was found to augment the growth inhibitory effects of 5-fluorouracil (5-FU) against RBE cells. Utilizing pull-down assay and liquid chromatography, we identify the clathrin heavy chain accompanied by GRP78/BiP as a COP35-binding partner. In summary, we identify COP35 as a possible candidate for peptide-targeted therapies for CCA. Mol Cancer Res; 9(6); 688–701. ©2011 AACR.
Differential Hypoxic Regulation of Hypoxia-Inducible Factors 1α and 2α
Authors: Lin Qun , Cong Xiangyu , Yun Zhong 
Published: May 2011

AbstractThe hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a large number of cancers. Recent evidence suggests that HIF-2α appears to be preferentially expressed in neuronal tumor cells that exhibit cancer stem cell characteristics. These observations suggest that expression of HIF-1α and HIF-2α is differentially regulated in the hypoxic tumor microenvironment. However, the underlying mechanisms remain to be fully investigated. In this study, we investigated the transcriptional regulation of HIF-1α and HIF-2α under different physiologically relevant hypoxic conditions. We found that transcription of HIF-2α was consistently increased by hypoxia, whereas transcription of HIF-1α showed variable levels of repression. Mechanistically, differential regulation of HIF-α transcription involved hypoxia-induced changes in acetylation of core histones H3 and H4 associated with the proximal promoters of the HIF-1α or HIF-2α gene. We also found that, although highly stable under acute hypoxia, HIF-1α and HIF-2α proteins become destabilized under chronic hypoxia. Our results have thus provided new mechanistic insights into the differential regulation of HIF-1α and HIF-2α by the hypoxic tumor microenvironment. These findings also suggest an important role of HIF-2α in the regulation of tumor progression under chronic hypoxia. Mol Cancer Res; 9(6); 757–65. ©2011 AACR.
Dietary α-Linolenic Acid Inhibits Arterial Thrombus Formation, Tissue Factor Expression, and Platelet Activation
Authors: Holy Erik W. , Forestier Marc , Richter Eva K. , Akhmedov Alexander , Leiber Florian , Camici Giovanni G. , Mocharla Pavani , Lüscher Thomas F. , Beer Jürg H. , Tanner Felix C. 
Published: May 2011

Objective—

Plant-derived α-linolenic acid (ALA) may constitute an attractive cardioprotective alternative to fish-derived
n
-3 fatty acids. However, the effect of dietary ALA on arterial thrombus formation remains unknown.

Methods and Results—

Male C57Bl/6 mice were fed a high-ALA or low-ALA diet for 2 weeks. Arterial thrombus formation was delayed in mice fed a high-ALA diet compared with those on a low-ALA diet (n=7;
P
<0.005). Dietary ALA impaired platelet aggregation to collagen and thrombin (n=5;
P
<0.005) and decreased p38 mitogen-activated protein kinase activation in platelets. Dietary ALA impaired arterial tissue factor (TF) expression, TF activity, and nuclear factor-κB activity (n=7;
P
<0.05); plasma clotting times and plasma thrombin generation did not differ (n=5;
P
=not significant). In cultured human vascular smooth muscle and endothelial cells, ALA inhibited TF expression and activity (n=4;
P
<0.01). Inhibition of TF expression occurred at the transcriptional level via the mitogen-activated protein kinase p38 in smooth muscle cells and p38, extracellular signal-regulated kinases 1 and 2, and c-Jun N-terminal kinases 1 and 2 in endothelial cells.

Conclusion—
ALA impairs arterial thrombus formation, TF expression, and platelet activation and thereby represents an attractive nutritional intervention with direct dual antithrombotic effects.
Multifaceted Role of Plasminogen Activator Inhibitor-1 in Regulating Early Remodeling of Vein Bypass Grafts
Authors: Ji Yan , Strawn Tammy L. , Grunz Elizabeth A. , Stevenson Meredith J. , Lohman Alexander W. , Lawrence Daniel A. , Fay William P. 
Published: May 2011

Objective—
The role of plasminogen activator inhibitor-1 (PAI-1) in vein graft (VG) remodeling is undefined. We examined the effect of PAI-1 on VG intimal hyperplasia and tested the hypothesis that PAI-1 regulates VG thrombin activity.

Methods and Results—

VGs from wild-type (WT),
Pai1
−/−
, and PAI-1-transgenic mice were implanted into WT,
Pai1
−/−
, or PAI-1-transgenic arteries. VG remodeling was assessed 4 weeks later. Intimal hyperplasia was significantly greater in PAI-1-deficient mice than in WT mice. The proliferative effect of PAI-1 deficiency was retained in vitronectin-deficient mice, suggesting that PAI-1's antiproteolytic function plays a key role in regulating intimal hyperplasia. Thrombin-induced proliferation of PAI-1-deficient venous smooth muscle cells (SMC) was significantly greater than that of WT SMC, and thrombin activity was significantly higher in PAI-1-deficient VGs than in WT VGs. Increased PAI-1 expression, which has been associated with obstructive VG disease, did not increase intimal hyperplasia.

Conclusion—
Decreased PAI-1 expression (1) promotes intimal hyperplasia by pathways that do not require vitronectin and (2) increases thrombin activity in VG. PAI-1 overexpression, although it promotes SMC migration in vitro, did not increase intimal hyperplasia. These results challenge the concept that PAI-1 drives nonthrombotic obstructive disease in VG and suggest that PAI-1's antiproteolytic function, including its antithrombin activity, inhibits intimal hyperplasia.
Understanding Initiation Behavior in Chinese Negotiations: An Examination of Distinctions across Three Regional Subcultures
Authors: Volkema Roger J. 
Published: May 2011

AbstractWhile many individuals speak of China as a single trading partner, in reality Greater China consists of at least three regional subcultures ‐ the People’s Republic of China, Hong Kong, and Taiwan. These regions differ in terms of their historical development, values, and traditions, which have implications for what to expect in negotiations. This article examines the cultural differences found in these three regions of Greater China, with particular attention to an often overlooked yet critical stage of the negotiation process ‐ the initiation stage. Using data from the GLOBE Study on cultural practices and values, propensity to initiate a negotiation (engage a counterpart, make a request or demand, and optimize that request) is estimated for each regional subculture. The implications of these findings for practitioners and future research are discussed.
Talk of Corruption in Eastern Indonesian Communities: Reactions to Local Government in the Post-Suharto Reform Era
Authors: Erb Maribeth 
Published: May 2011

AbstractEastern Indonesia, most notably Nusa Tenggara Timor province, has been frequently referred to as the poorest region in Indonesia and claims have recently been made that it is the most corrupt as well. The spread of corruption in the post-Suharto period, with the introduction of regional autonomy and decentralisation, has often been commented on; but what is corruption? How do people define it? This paper uses an anthropological lens on corruption to suggest that with the spread of ideas of ‘good governance’ and ‘democracy’, one significant way that local communities in NTT province engage with the state and define corruption is as an abuse of power and non-consultation with the populace. This has become particularly acute with the government belief that new investment opportunities in the reform era will become a road to development and prosperity for local communities, who are, however, seen to be unable to provide for themselves or seek their own ways out of poverty. Several regional governments in NTT province have taken advantage of new laws put into effect in the reform era to award mining concessions to domestic and foreign mining companies. A swell of protest has arisen across the province, however, and an increasing critique of poor government and corrupt practices focuses on these mining contracts.
Sawerigading vs. Sharia: Identities and Political Contestation in Decentralised Indonesia
Authors: Robinson Kathryn 
Published: May 2011

AbstractIslamist groups are attempting to shape Indonesia’s political landscape post-New Order through advocating local regulations based on sharia in districts newly empowered by regional autonomy. In the province of South Sulawesi, which was gripped by a separatist Islamic rebellion in the 1950s and 1960s, the former rebel leader, Kahar Muzakkar, is invoked in a movement to implement sharia-based local regulations. However, the politics of decentralisation are also associated with a resurgence of local cultural identities, which embrace non-Islamic traditions. In Muslim South Sulawesi, these claims have been expressed through the ceremonial re-installation of local traditional rulers and performance of public ceremonies to care for the sacred regalia that legitimate authority, but also through government-funded seminars that explore distinctive Bugis and Makassarese cultural traditions. These claims to power can be understood as a reaction to the taming of cultural difference by the Suharto regime, but they also represent vehicles for local elites to assume power. Based on an analysis of one of the district cultural seminars and accompanying cultural festival, this paper examines the manner in which cultural traditions are strategically mobilised in South Sulawesi, in a rival movement to the Islamist claims to implement sharia.
Translocal Networks and Globalisation within Indonesia: Exploring the Hadhrami Diaspora from the Archipelago’s North-East
Authors: Slama Martin 
Published: May 2011

AbstractThis article contributes to the study of diasporic aspects of today’s Eastern Indonesia by emphasizing its long history of translocal connections, as well as the multiplicity and acceleration of contemporary flows. It focuses on the Hadhrami diaspora, i.e., Indonesians of Arabic descent whose ancestors migrated from the Hadhramaut (located in today’s Republic of Yemen) to almost all parts of the archipelago. Today, Hadhramis in north-eastern Indonesia, the region this article concentrates on, form distinct communities and maintain translocal networks. There already in colonial times, Hadhramis institutionalised their networks through an Islamic organisation called Al-Khairaat. The article investigates how the translocal networks in north-eastern Indonesia have developed, especially during the New Order and afterwards, when Hadhramis from the region increasingly incorporated Java, especially Jakarta, into their networks. Reconsidering post-Suharto transformations that are part of a globalisation within Indonesia, the article concludes that their networks connect now the north-eastern periphery and Indonesia’s centre more intensively than ever. And, as a consequence of this expansion, Hadhramis from north-eastern Indonesia were able to enter national elite circles in Jakarta.
Jewish Novellas in a Greek and Roman Age: Fiction and Identity
Authors: Wills Lawrence M. 
Published: May 2011

AbstractAlthough Jewish novellas (Esther, Daniel, Tobit, Judith, and Joseph and Aseneth) have received more attention recently as a distinct genre within ancient Jewish literature, their relation to Greek and Roman novels is still debated. This article argues that, although some of the Jewish novellas arise earlier, they should be considered part of the same broad category of novelistic literature. The rich research on the cultural context of Greek and Roman novels applies to the Jewish as well. But a further question is also explored: if the Jewish texts were originally considered fictional, how did they come to be considered biblical and historical? Two suggestions are proposed: the protagonists of the narratives first came to be revered as heroes of the faith aside from the texts, and the rise of “biblical history” required the use of Esther and Daniel to fill in the gaps in the chronology.
Stringency in Qumran?
Authors: Heger Paul 
Published: May 2011

AbstractSome scholars allege a stringent ideology behind the severe Qumranic halakhot in contrast to putative leniencies in parallel rabbinic rulings. Vered Noam contends that the rabbinic propensity for leniency and innovativeness, versus the opposite Qumranic approach are the source of their disputes. Thus, Qumranic strictness is not “objective” but relative to the lenient rabbinic law. This paper critically scrutinizes Noam’s thesis, and will posit that the halakhot of Qumran are founded on a literal adherence to Scripture versus rabbinic pragmatism. The study discusses Noam’s cited examples, offering contrasting explanations. It deliberates about the difference between disputes concerning interpretations and physical facts, the rationales behind the various classifications, and the relationship between the degrees of holiness and the degrees of impurity.
Conversos and Novamente Convertidos: Law, Religion, and Identity in the Portuguese Kingdom and Empire
Authors: Xavier Ângela Barreto 
Published: May 2011

AbstractIn this essay, I intend to demonstrate that the foundations of the attitudes of the Portuguese crown and its agents in relation to the native populations living in the imperial territories were mainly inspired by the relations in Portugal with Jews, and later, Conversos. Besides the strong influence of classical inspiration and a rereading of medieval travelers on the construction of the imperial territories, the ways of thinking about, identifying, and governing internal others served as a reference guide to interpret and model the social situations that emerged in the Portuguese imperial territories. Indeed, the establishment of analogies between the populations of the kingdom and imperial populations had a great practical impact, and molded a good part of the political solutions that were delineated initially as extra territorium, particularly those in the territory of Goa.
Learning by Example: Exempla in Jerome’s Translations and Revisions of Biblical Books
Authors: Skemp Vincent T.M. 
Published: May 2011

AbstractJerome’s interest in provinding Exempla for his readers in his letters and the Vitae Patrum extended to his translations and revisions of canonical Books—Ruth 4,11; Deut 29,22(23), Esth 1,18; Zech 13,4—and to a book he considered non-canonical (Tob 2,12). Jerome related the noun exemplum to a variety of lexemes in the semantic field of obiecta aversionis. His views regarding the regulation of female behavior played a role in the plus in Esth 1,18. He viewed Ruth to some extent as a positive exemplum for his female audience, although he likely had conflicted feelings about the fact that the widow remarried. Although the lexeme does not occur in the Book of Judith, his predilections for Judith as exemplum of the chaste and virtuous widow was the impetus for the pluses in Jdt 16,26 and 10,4.
Missional Churches in Secular Societies: Theology Consults Sociology
Authors: Hughson, S.J. Thomas 
Published: May 2011

AbstractThe church is missionary by nature. But what about public church mission in secular societies? Furious religion mobilizing against rebarbative secularity? Withdrawal to seek exemplary perfection? To the contrary, theologically principled consultation with the sociology of J. Casanova on deprivatized religion leads to public witness in modern societies. Public theology can interpret deprivatized religion as an expression of prophetic and kingly elements in church mission. However, sociology leaves the priestly element as if private. What might ecclesiology, missiology, and public theology say about a public aspect of the priestly element in the church's witness in modern societies?
Christian Doctrine and Free Church Ecclesiology: Recent Developments among Baptists in the Southern United States
Authors: Fiddes Paul 
Published: May 2011

AbstractThe main substance of this article is an extended review of a recent book by a Southern Baptist historical theologian, Malcolm Yarnell, entitled The Formation of Christian Doctrine, which aims to root the development of doctrine in a free-church ecclesiology. This review offers the opportunity to examine a spectrum of ecclesiologies that has recently emerged among Baptists in the Southern region of the United States of America. Four 'conservative' versions of ecclesiology are identified, which are named as 'Landmarkist', 'Reformed', 'Reformed-Ecumenical' and 'Conservative Localist'. Four 'moderate' versions are similarly identified, and named as 'Voluntarist', 'Catholic', 'Moderate Localist' and 'World-Baptist'. While these categories are not intended to be mutually exclusive, the typology is useful both in positioning Yarnell's particular thesis, and in making comparisons with recent Baptist ecclesiology in Great Britain, which has focussed on the concept of covenant. Yarnell's own appeal to covenant is unusual in Southern Baptist thinking, and means that he cannot be easily fitted into the typology suggested. Though he belongs most evidently to the group named here as 'Conservative Localists', and is overtly opposed to any concept of a visible, universal church except in an eschatological sense, it is suggested that his own arguments might be seen as tending towards a more 'universal' view of the reality of the church beyond its local manifestation. His own work thus offers the promise that present polarizations among Baptists in the southern United States might, in time, be overcome.
Can Pietism Change the World? Reconsidering Hegel's Tutelage of 'Faith'
Authors: Barnett William 
Published: May 2011

AbstractThe legacy of the ecclesial renewal movement known as Pietism is debated on questions of how it envisions the church's relation to the world. On the one hand, there are denominations today that invoke the legacy of Pietism as a resource in constructing a missional identity and a clear ethic of social engagement and transformation. On the other hand, there are critics, such as Karl Barth, who register Pietism as a phenomenon that fosters individualism rather than social-mindedness. Barth blames Pietism's inward concept of authority. This essay is an attempt to temper the claims of such critics through a close reading of the analysis of the 'faith' consciousness found in G.W.F. Hegel's Phenomenology of Spirit. In contrast to Barth, Hegel offers a reading of Pietism's inward concept of authority as forming dissatisfied social agents, rather than atomistic individuals fundamentally alienated from one another. On Hegel's account, the Pietist experiences an essential or spiritual belonging to the actual social world, yet she is continually dissatisfied with the external actualization of this spiritual relationship. Thus, Hegel provides a way for Pietist traditions to conceptually integrate the emphasis on inward experience with a clear ethic of social participation and responsible engagement.
Systematic revision of the sibling species belonging to the Pristaulacus compressus group (Hymenoptera: Aulacidae)
Authors: Turrisi Giuseppe Fabrizio 
Published: May 2011

AbstractThe Pristaulacus compressus species group is revised and illustrated. It has a strictly western Palearctic range and includes four sibling species, two of which are newly described: P. rapuzzii Turrisi, sp.n. (Lebanon) and P. samai Turrisi, sp.n. (Syria). Besides external characters of the tagmata, especially the sculpturation and shape of the head and occipital carina, the taxonomic treatment of this species group takes into account new diagnostic features of the male genital capsule, including the general shape and the shape of the apex of the paramere, lamina volsellaris and penis valve. The previous key for identifi cation of the Palearctic species of Pristaulacus is modifi ed to include the two new species. A discussion on taxonomy, biogeography and host preference of the treated species is provided.
A Dumbbell Pattern in NGO Fundraising: The Case of World Vision
Authors: Yushan Xu , Junkui Han 
Published: May 2011

AbstractThis essay first classifies four patterns of fundraising according to the number of donors and the number of beneficiaries involved: one to one, one to many, many to one, and many to many, each with its own pros and cons. The case study reveals that the donors ‐ organization ‐ recipients structure of fundraising manifested by World Vision’s efforts resembles a “dumbbell”: on the outside ends, large numbers of donors and beneficiaries are effectively connected with one another by the organization in the middle. This pattern, which represents the successful accomplishment of the organization’s mission, offers valuable lessons in fundraising and grant disbursals to all NGOs in China.