bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated limb perfusion with the tumor‐targeting human monoclonal antibody–cytokine fusion protein L19‐TNF plus melphalan and mild hyperthermia in patients with locally advanced extremity melanoma
Authors: Papadia Francesco , Basso Valeria , Patuzzo Roberto , Maurichi Andrea , Di Florio Annabella , Zardi Luciano , Ventura Elisa , González‐Iglesias Reinerio , Lovato Valeria , Giovannoni Leonardo , Tasciotti Annaelisa , Neri Dario , Santinami Mario , Menssen Hans D. , De Cian Franco 
Published: June 2012

AbstractBackgroundL19‐TNF is a tumor‐targeting immunocytokine composed of the human L19 antibody binding to extra domain B (ED‐B) of fibronectin of newly formed blood vessels, and of human TNF. This exploratory trial evaluates safety and clinical activity of L19‐TNF plus melphalan‐containing isolated limb perfusion (ILP) in extremity melanoma patients.MethodsSeven and 10 patients received 325 µg and 650 µg of L19‐TNF, respectively, during the ILP. Patients were studied for safety, tolerability, and clinical activity of this experimental L19‐TNF ILP procedure.ResultsNon‐hematologic toxicity of L19‐TNF ILP was very low, but severe myelosuppression was seen in four patients. Although L19‐TNF was administered at a TNF‐equivalent dose of only 3.13 and 6.25% of the approved TNF (Beromun®) dose of 4 mg, L19‐TNF ILP induced objective responses in 86 and 89% of patients, respectively, including a complete response (CR) in 5/10 patients treated with L19‐TNF ILP at 650 µg that was durable at 12 months in four patients. No CR was seen at 325 µg of L19‐TNF.ConclusionsILP with L19‐TNF had a favorable safety and a promising activity profile at a dose of 650 µg of L19‐TNF, supporting the exploration of higher L19‐TNF doses and a Phase II trial comparing L19‐TNF ILP with standard melphalan‐containing ILP. J. Surg. Oncol. 2013;107:173–179. © 2012 Wiley Periodicals, Inc.
Geographic variation in utilization of sentinel lymph node biopsy for intermediate thickness cutaneous melanoma
Authors: Martinez Steve R. , Shah Dhruvil R. , Maverakis Emanual , Yang Anthony D. 
Published: June 2012

AbstractBackground and ObjectivesSentinel lymph node biopsy (SLNB) is the standard for evaluation of the draining lymphatic basin for intermediate thickness melanoma. Despite this, SLNB has not been uniformly adopted. We hypothesized that there are geographic areas of the United States where patients are less likely to receive SLNB.MethodsThe Surveillance, Epidemiology, and End Results database was queried for patients who underwent surgery for intermediate thickness cutaneous melanoma (Breslow thickness 1.00–4.00 mm) from 2004 to 2008. Patients were categorized according to geographic area based on the reporting registry. Multivariate logistic regression models predicted use of SLNB.ResultsEntry criteria were met by 8,957 patients. On multivariate analysis, patients from the South were less likely (OR 0.54, CI 0.48–0.62; P < 0.001) to receive a SLNB. Additional factors associated with a decreased likelihood of receiving a SLNB included head and neck primary tumor site, high or unknown serum LDH, Asian, Hispanic, Native American or unknown race, and increasing age.ConclusionsPatients from the South were less likely to receive a SLNB for an intermediate thickness cutaneous melanoma. This report of geographic disparities on a national level should be confirmed locally to better guide interventions aimed at eliminating these disparities. J. Surg. Oncol. 2012; 106:807–810. © 2012 Wiley Periodicals, Inc.
Controlled Synthesis and Ti—O Bond Stability of Star‐Shaped Biodegradable Polyesters via Titanate‐Initiated ROP of Cyclic Esters at Ambient Temperature
Authors: Fan Jun‐Bing , Long Feng , Aldred Matthew P. , Li Ya‐Jing , Liang Zhi‐Wu , Zhu Ming‐Qiang 
Published: June 2012

AbstractFour‐arm star‐shaped PCL polymers are synthesized using iPT as initiator for the controlled ROP of CL at 25–40 °C. The number‐average molecular weights of the star‐shaped Ti(O‐PCL)4 with narrow molecular weight distributions are proportional to the molar ratios of monomer to initiator. The four‐branch star‐shaped structures of Ti(OPCL)4 are confirmed through polymer hydrolysis monitoring by GPC, which indicates that the stability of the Ti—O bond in the core of the star‐shaped polymer chain increases with the increase of polymer molecular weights. The star‐shaped Ti(O‐PCL)4 can act as a macroinitiator for successive block copolymerization with d,l‐Lactide in bulk at 60 °C.
Loose‐Fit Polypseudorotaxanes Fabricated by γ‐CDs Threaded Onto a Single PNIPAAm‐PEG‐PNIPAAm Chain in Aqueous Solution
Authors: Gao Peng , Wang Jin , Wang Pei‐Jing , Ye Lin , Zhang Ai‐Ying , Feng Zeng‐Guo 
Published: June 2012

AbstractWhen γ‐CDs are added to an aqueous solution of PNIPAAm‐b‐PEG‐b‐PNIPAAm block copolymer, they are threaded onto the polymer chains to give loose‐fit polypseudorotaxanes (PPRs). The inclusion complexation shows a marked dependence on the length of the PNIPAAm blocks although the threaded γ‐CDs are preferably located on the central PEG block. The structure of the resulting PPRs is characterized by using XRD, 1H and 13C CP/MAS NMR, TGA FTIR, and DSC analyses. Because of the mismatched fit between the guest polymer chain and the cavity of the host γ‐CDs, these PPRs may be promising in applications as solid stimuli‐responsive materials.
Brain amyloid and cognition in Lewy body diseases
Authors: Gomperts Stephen N. , Locascio Joseph J. , Marquie Marta , Santarlasci Andrea L. , Rentz Dorene M. , Maye Jacqueline , Johnson Keith A. , Growdon John H. 
Published: June 2012

AbstractMany patients with PD develop PD with dementia (PDD), a syndrome that overlaps clinically and pathologically with dementia with Lewy bodies (DLB); PDD and DLB differ chiefly in the relative timing of dementia and parkinsonism. Brain amyloid deposition is an early feature of DLB and may account, in part, for its early dementia. We sought to confirm this hypothesis and also to determine whether amyloid accumulation contributes to cognitive impairment and dementia in the broad range of parkinsonian diseases. Twenty‐nine cognitively healthy PD, 14 PD subjects with mild cognitive impairment (PD‐MCI), 18 with DLB, 12 with PDD, and 85 healthy control subjects (HCS) underwent standardized neurologic and neuropsychological examinations and Pittsburgh compound B (PiB) imaging with PET. Apolipoprotein E (ApoE) genotypes were obtained in many patients. PiB retention was expressed as the distribution volume ratio using a cerebellar tissue reference. PiB retention was significantly higher in DLB than in any of the other diagnostic groups. PiB retention did not differ across PDD, PD‐MCI, PD, and HCS. Amyloid burden increased with age and with the presence of the ApoE ε4 allele in all patient groups. Only in the DLB group was amyloid deposition associated with impaired cognition. DLB subjects have higher amyloid burden than subjects with PDD, PD‐MCI, PD, or HCS; amyloid deposits are linked to cognitive impairment only in DLB. Early amyloid deposits in DLB relative to PDD may account for their difference in the timing of dementia and parkinsonism. © 2012 Movement Disorder Society
Combined effect of β‐nucleating agent and processing melt temperature on the toughness of impact polypropylene copolymer
Authors: Luo Feng , Xu Chenlong , Ning Nanying , Wang Ke , Deng Hua , Chen Feng , Fu Qiang 
Published: June 2012

AbstractThe phase morphology and toughening behavior of impact polypropylene copolymer (IPC) with and without nucleating agent (NA), prepared at different processing melt temperatures (Tp), were investigated. Interestingly, three different structures can be formed in the IPC samples by adding NA or tuning Tp. A well‐defined core–shell structure is obtained in samples with α‐NA or without NA prepared at all Tp. A developing multilayered structure is mainly formed at high Tp with added β‐NA, while an incomplete phase separation structure with interpenetrating chains is the dominant structure for IPC samples prepared at low Tp with added β‐NA. In this case, because of the synergistic effect between phase morphology and relatively high β‐form crystal content, the chain interaction among the components and chain mobility of the amorphous portion of IPC are distinctly improved, resulting in a largely improved toughness under 0 °C. This improvement in toughness is very important for applications. © 2012 Society of Chemical Industry
Thermionic emission characterization of boron‐doped microcrystalline diamond films at elevated temperatures
Authors: Paxton William F. , Wade Travis , Howell Mick , Tolk Norman , Kang Wang P. , Davidson Jim L. 
Published: June 2012

AbstractA boron‐doped polycrystalline diamond film was deposited on a molybdenum substrate and resistively heated in a high vacuum environment. The thermally excited emission current as a function of cathode temperature was measured. This phenomenon, known as thermionic emission, is characterized by electron emission arising from a surface at elevated temperatures and is described by the Richardson equation. The observed thermionic emission current from the diamond sample followed the Richardson equation from which a work function of 4.43 eV and a Richardson constant of ∼60 A/cm2K2 were observed. This indicates boron‐doped polycrystalline diamond behaves as an interesting thermionic emitter for possible energy conversion and other electron emission applications.
Investigation of the thermal‐transport properties for silicon nanofilm covered with graphene via nonequilibrium molecular dynamics
Authors: Gao Yufei , Jing Yuhang , Meng Qingyuan , Zhang Lu , Liu Jiaqiu , Qin Xian 
Published: June 2012

AbstractNonequilibrium molecular dynamics (NEMD) is used to investigate the thermal‐transport properties of a silicon nanofilm covered with graphene (Gr/Si/Gr nanofilm). The investigation results demonstrate that graphene can enhance the thermal‐transport properties and weaken the ballistic characteristics of silicon nanofilm. Under the action of a small strain, the thermal conductivity decreases with the growth of tensile and compressive strain, respectively. In addition, the higher‐frequency phonons in graphene give more contributions to the variation of thermal conductivity of Gr/Si/Gr nanofilm under strain. The thermal conductivity of Gr/Si/Gr nanofilm increases linearly with the increase of temperature in the lower‐temperature regime due to the quantum effect, and begins to clearly decrease when the temperature exceeds a definite value.
Young children's analogical reasoning in science domains
Authors: Haglund Jesper , Jeppsson Fredrik , Andersson Johanna 
Published: June 2012

AbstractThis exploratory study in a classroom setting investigates first graders' (age 7–8 years, N = 25) ability to perform analogical reasoning and create their own analogies for two irreversible natural phenomena: mixing and heat transfer. We found that the children who contributed actively to a full‐class discussion were consistently successful at making analogical comparisons between known objects provided by a researcher and that some of the children could come up with their own analogies for the abstract natural phenomena with which they interacted. The use of full‐class and small‐group settings, shared laboratory experiences of the phenomena and children's drawings as different kinds of scaffolding was found to be helpful for the children's analogical reasoning. As an implication for science education, self‐generated analogies are put forward as a potential learning tool within a constructivist approach to education. © 2012 Wiley Periodicals, Inc. Sci Ed 96:725–756, 2012
A fuzzy binary clustered particle swarm optimization strategy for thermal unit commitment problem with wind power integration
Authors: Chakraborty Shantanu , Senjyu Tomonobu , Saber Ahmed Yousuf , Yona Atsushi , Funabashi Toshihisa 
Published: June 2012

AbstractThis paper presents a fuzzy‐logic‐based binary particle swarm optimization (BPSO) method for solving short‐term thermal unit commitment problem integrated with an equivalent wind–battery system. As a renewable power source, wind power is injected stochastically with the model. To handle the uncertainty and intermittency due to the wind power integration, the trivial crisp problem formulations are modified by introducing fuzzy logic. Moreover, since it is also forecast, load demand along with the spinning reserve and production cost are taken under fuzzification. The potential solutions are distributed among several clusters based on a clustering scheme which exploits their associated fitness values. The fitness value is functionalized by combining the objective function, penalty function, and the aggregated fuzzy membership function. After clustering, each solution is updated according to the velocity and position BPSO refinement functions. The clustering scheme inherently introduces multipopulation‐based search space exploration in PSO. Therefore, this algorithm allows the particles to explore a larger search space in the problem domain by diversification of particles. Simulation results are provided to show the effectiveness of the proposed method by scrutinizing two different power systems. © 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Impact of alfuzosin on sexual function in Taiwanese men with benign prostatic hyperplasia
Authors: Hwang Thomas I.S. , Chu Sheng‐Hsien , Lin Mao‐Sheng , Chen Chih‐Shou , Lee Liang‐Ming , Chang Hong‐Chiang , Yeh Shauh‐Der , Chen Wen‐Hsiang , Chiang Po‐Hui 
Published: June 2012

AbstractTo assess the effect of alfuzosin (XATRAL) 10 mg once daily on sexual function in men with moderate to severe lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), patients with suggestive symptomatic BPH, an International Prostate Symptom Score (IPSS) >8 (range of scores, 0–35), and sexual attempts at least once per month were enrolled. All patients received alfuzosin 10 mg once daily for 24 weeks and were asked to complete the IPSS test and Male Sexual Health Questionnaire at weeks 0 (baseline), 1, 4, 12, and 24. Other assessments included the International Index of Erectile Function—five‐item version (range of scores: 5–25), as well as onset of action and peak urinary flow rate (Qmax). From September 2006 to May 2008, 279 patients were enrolled from nine centers in Taiwan. At 24 weeks, alfuzosin effectively improved LUTS and quality of life, as demonstrated by a reduction in the IPSS total score (17.3 vs. 9.9, p < 0.001) and the IPSS bother score (3.8 vs. 2.5, p < 0.001). The majority (85%) of patients perceived an improvement of urinary symptoms within 1 month of administration. In patients with an International Index of Erectile Function—five‐item version score of ≤16, alfuzosin significantly improved erectile disorder and satisfaction subscores at each time point (p ≤ 0.02). Prolonged‐release alfuzosin effectively improved LUTS, quality of life, erectile function, and sexual satisfaction in men with BPH and mild to severe erectile dysfunction. Alfuzosin is an effective treatment option for the management of patients with BPH/LUTS and concomitant sexual dysfunction.
It Pays to Follow the Leader: Acquiring Targets Picked by Private Equity
Authors: Dittmar Amy , Li Di , Nain Amrita 
Published: June 2012

AbstractThis paper examines the impact of financial sponsor competition on corporate buyers. We find that corporate acquirers who purchase targets that financial buyers also bid on outperform corporate acquirers who buy targets bid on by corporate firms only. Deal characteristics, acquirer abilities, and observable target characteristics cannot explain this difference in returns. Corporate acquirers have higher returns when they follow a first bid by a financial buyer rather than a first bid by another corporate buyer. The results suggest that financial bidders identify targets with high potential for value improvement and winning corporate bidders are competent in exploiting this potential.
Does God know what it's like not to know?
Authors: LOVERING ROB 
Published: June 2012

AbstractThe topic of divine omniscience is well-trodden ground, with philosophers and theologians having asked virtually every question there is to ask about it. The questions regarding God's omniscience to be addressed here are as follows. First, is omniscience best understood as maximal propositional knowledge along with maximal experiential knowledge (both to be defined shortly)? I argue that it is. Second, is it possible for God to be essentially omniscient? I argue that it is not.
Modeling of annular-laser-beam-driven plasma jets from massive planar targets
Authors: Kmetík V. , Limpouch J. , Liska R. , Váchal P. 
Published: June 2012

AbstractProduction of sharply collimated high velocity outflows – plasma jets from massive planar targets by a single laser beam at PALS facility is clarified via numerical simulations. Since only a few experimental data on the intensity distribution in the interaction beam near the focus are available for the PALS facility, the laser beam profile was calculated by a numerical model of the laser system and the interaction optics. The obtained intensity profiles are used as the input for plasma dynamic simulations by our cylindrical two-dimensional fluid code PALE. Jet formation due to laser intensity profile with a minimum on the axis is demonstrated. The outflow collimation improves significantly for heavier elements, even when radiative cooling is omitted. Using an optimized interaction beam profile, a homogeneous jet with a length exceeding its diameter by several times may be reliably generated for applications in laboratory astrophysics and impact ignition studies.
Allez donc sortir des sentiers battus!La production de l'effet de sensextraordinaireparalleretvenir
Authors: BRES JACQUES , LABEAU EMMANUELLE 
Published: June 2012

RÉSUMÉCet article s'attache à l'analyse approfondie de la périphraseauxiliaire aller / venir + V. infinitifdans un emploi peu documenté que la tradition nommeallure extraordinaire. Il prend appui sur un corpus de 500 occurrences relevé dans divers genres du discours (journalistique, littéraire, conversationnel, électronique). On propose dans un premier temps une description générale du fonctionnement de l’extraordinaire; on explicite ensuite précisément cet effet de sens, avant d'expliquer le mécanisme de sa production.
A technique for mapping Fe/Mg‐rich phyllosilicates on Mars using THEMIS multispectral thermal infrared images
Authors: Viviano Christina E. , Moersch Jeffrey E. 
Published: June 2012

We present a method for mapping exposures of Fe/Mg‐rich phyllosilicates on the Martian surface using THEMIS daytime multispectral thermal infrared images. The primary utility of this technique comes from the fact that THEMIS coverage is near‐global at 100 m/pixel, so it offers the opportunity to extend and improve upon phyllosilicate maps created using CRISM and/or OMEGA near‐infrared data alone. The spectral index formulation used for this mapping consists of a sum of spectral band ratios, weighted in different proportions. An initial formulation of the index was determined using a suite of synthetic spectra containing varying proportions of a Martian basalt spectrum and a laboratory phyllosilicate spectrum. A scene‐specific formulation was then optimized by exploiting the correlation between pixels the initial formulation flags in each THEMIS scene as containing phyllosilicates and those identified in overlapping CRISM data. Once the optimal formulation of the index is determined, it is applied to the entire THEMIS scene, extending the map of phyllosilicates beyond the area of overlapping CRISM coverage. The method is illustrated using 12 THEMIS scenes from the Mawrth Vallis and Nili Fossae regions. The new THEMIS‐derived maps of Fe/Mg‐rich phyllosilicates in these two regions have approximately double the coverage provided by CRISM data. The cross‐wavelength and cross‐instrument approach we use to derive phyllosilicate indices for THEMIS data could potentially be used to define spectral indices for mapping other compositions of interest on Mars that possess spectral features in more than one spectral region.
Anomalous diffusion and dynamical correlation between the side chains and the main chain of proteins in their native state
Authors: Cote Yoann , Senet Patrick , Delarue Patrice , Maisuradze Gia G. , Scheraga Harold A. 
Published: June 2012

Structural fluctuations of a protein are essential for a protein to function and fold. By using molecular dynamics (MD) simulations of the model α/β protein VA3 in its native state, the coupling between the main-chain (MC) motions [represented by coarse-grained dihedral angles (CGDAs)
γ

n

based on four successive C

α

atoms (
n
- 1,
n
,
n
+ 1,
n
+ 2) along the amino acid sequence] and its side-chain (SC) motions [represented by CGDAs
δ

n

formed by the virtual bond joining two consecutive C

α

atoms (
n
,
n
+ 1) and the bonds joining these C

α

atoms to their respective C

β

atoms] was analyzed. The motions of SCs (
δ

n

) and MC (
γ

n

) over time occur on similar free-energy profiles and were found to be subdiffusive. The fluctuations of the SCs (
δ

n

) and those of the MC (
γ

n

) are generally poorly correlated on a
ps
time-scale with a correlation increasing with time to reach a maximum value at about 10 ns. This maximum value is close to the correlation between the
δ

n

(
t
) and
γ

n

(
t
) time-series extracted from the entire duration of the MD runs (400 ns) and varies significantly along the amino acid sequence. High correlations between the SC and MC motions [
δ
(
t
) and
γ
(
t
) time-series] were found only in flexible regions of the protein for a few residues which contribute the most to the slowest collective modes of the molecule. These results are a possible indication of the role of the flexible regions of proteins for the biological function and folding.
Acute alcohol effects on impulsivity: associations with drinking and driving behavior
Authors: McCarthy Denis M. , Niculete Maria E. , Treloar Hayley R. , Morris David H. , Bartholow Bruce D. 
Published: June 2012

AbstractAimsAlthough drink drivers exhibit higher levels of trait impulsivity, no studies have tested the hypothesis that drink drivers experience increased impulsivity while intoxicated. We tested this hypothesis for two impulsivity constructs: delay discounting and behavioral inhibition.DesignA within‐subjects study comparing performance of drink drivers and non‐drink drivers on behavioral measures of impulsivity in alcohol and no‐beverage sessions.SettingA laboratory setting at the University of Missouri.ParticipantsTwenty‐nine young adults who were at least moderate drinkers were recruited from the local community and the University of Missouri.MeasurementsImpulsivity was assessed using the Two Choice Impulsivity Paradigm (TCIP) and the Stop‐Signal Task. Participants also completed self‐report measures of binge drinking and trait impulsivity.FindingsIn the no‐beverage session, TCIP impulsive choices did not differ between drinking and driving groups (P = 0.93). In the alcohol session, drink drivers made more TCIP impulsive choices on both the ascending (P < 0.01) and descending limb (P < 0.01) of the blood alcohol concentration curve than their peers who did not drink and drive. Drinking and driving groups did not differ on the Stop‐Signal Task. Supplementary analyses indicated that effects for the TCIP were not explained by individual differences in trait impulsivity.ConclusionsIndividuals who report having three or more drinks before driving show greater impulsivity when under the influence of alcohol than those who do not report heavy drinking before driving.