bluuebunny/crossref_metadata_2025_split huggingface dataset:
CXCR4 enhances engraftment of muscle progenitor cells
Authors: Perez Antonio L. , Bachrach Estanislao , Illigens Ben M. W. , Jun Susan J. , Bagden Eric , Steffen Leta , Flint Alan , McGowan Francis X. , del Nido Pedro , Montecino‐Rodriguez Enca , Tidball James G. , Kunkel Louis M. 
Published: September 2009

AbstractCell‐based therapy is a possible avenue for the treatment of Duchenne muscular dystrophy (DMD), an X‐linked skeletal muscle‐wasting disease. We have demonstrated that cultured myogenic progenitors derived from the adult skeletal muscle side population can engraft into dystrophic fibers of non‐irradiated, non–chemically injured mouse models of DMD (mdx5cv) after intravenous and intraarterial transplantation, with engraftment rates approaching 10%. In an effort to elucidate the cell‐surface markers that promote progenitor cell extravasation and engraftment after systemic transplantation, we found that expression of the chemokine receptor CXCR4, whose ligand SDF‐1 is overexpressed in dystrophic muscle, enhances the extravasation of these cultured progenitor cells into skeletal muscle after intraarterial transplantation. At 1 day post‐transplantation, mice that received CXCR4‐positive enhanced green fluorescent protein (eGFP)‐positive cultured cells derived from the skeletal muscle side population displayed significantly higher amounts of eGFP‐positive mononuclear cells in quadriceps and tibialis anterior than mice that received CXCR4‐negative eGFP‐positive cells derived from the same cultured population. At 30 days posttransplantation, significantly higher engraftment rates of donor cells were observed in mice that received CXCR4‐positive cells compared with mice transplanted with CXCR4‐negative fractions. Our data suggest that CXCR4 expression by muscle progenitor cells increases their extravasation into skeletal muscle shortly after transplantation. Furthermore, this enhanced extravasation likely promotes higher donor cell engraftment rates over time. Muscle Nerve 40: 562–572, 2009
Cadaveric study of nerves supplying the membranous urethra
Authors: Song Lu‐Jie , Lu Hong‐Kai , Wang Jin‐Ping , Xu Yue‐Min 
Published: September 2009

AbstractAimsTo better understand the anatomy of the region of the male membranous urethra in order to preserve continence during radical cystectomy and prostatectomy.MethodsCadaveric dissections of 15 male specimens were undertaken to investigate the nerves to membranous urethra. The nerves were traced from both an intrapelvic approach and a perineal approach. The origin, course, and distribution of the branches to the membranous urethra region were investigated in detail.ResultsThe membranous urethra is innervated by branches of inferior hypogastric plexus (IHP) and intrapelvic and extrapelvic branches of pudendal nerve (PN). The pelvic nerve from IHP originated from the caudal most root of the pelvic splanchnic nerve, running along the surface of the levator ani muscle (LAM) to enter the membranous urethra at the 5 and 7 O'clock positions. In 40% of specimens we found that the intrapelvic branches were supplied by the PN. Before exiting the pudendal canal, PN gives off an intrapelvic branch that traverses the LAM to course with the pelvic nerve and innervate the membranous urethra; the distance between these intrapelvic branches and prostatic apex is 5.3 ± 1.8 mm. The branches originating from the dorsal nerve of penis innervate the membranous urethra in 53.3% of specimens; these nerve branches are located 4.2 ± 1.1 mm from the prostatic apex.ConclusionsDissection of the seminal vesicles and the prostatic apex during radical cystectomy and prostatectomy likely injures the nerve responsible for continence. Neurourol. Urodynam. 29:592–595, 2010. © 2009 Wiley‐Liss, Inc.
Urine production and bladder diary measurements in women with type 2 diabetes mellitus and their relation to lower urinary tract symptoms and voiding dysfunction
Authors: Fayyad Abdalla M. , Hill Simon R. , Jones Geraint 
Published: September 2009

AbstractAimsTo establish bladder diary measurements in women with type 2 diabetes mellitus (DM) and their relation to bothersome LUTS and voiding dysfunction.MethodsOne hundred ten women with type 2 DM were assessed using the King's Health and ICIQ‐FLUTS questionnaires. Patients were divided into bothersome and non‐bothersome LUTS according to bother scale of the ICIQ‐FLUTS. Voiding was assessed with free flow rate and residuals. Three day bladder diary measurements were obtained and 24 hr, daytime and nighttime urine production, daytime frequency, nighttime frequency, maximum bladder capacity, mean voided volume, mean daytime and nighttime voided volumes, and incontinence episodes were recorded. Differences in bladder diary measurements between bothersome and non‐bothersome groups and between normal and abnormal voiding groups were established with multivariate analysis. Correlations between urine production and voided volumes and between diary measurements and domains of the ICIQ‐FLUTS were established.ResultsThere were no differences in urine production, between bothersome and non‐bothersome LUTS groups. Women with bothersome LUTS had greater nighttime frequency (2.6 vs. 1.4) and number of incontinence episodes (3.3 vs. 0.4). Abnormal voiding group had higher nocturnal urine production (1,007 ml vs. 654 ml). There were significant correlations between nighttime frequency, number of incontinence episodes, and the storage and incontinence domains of the ICIQ‐FLUTS. Bladder capacity significantly increased with increased total urine volumes.ConclusionsBothersome LUTS in DM is not associated with increased urine production. Bladder capacity increased with total urine volume. Nocturia and incontinence episodes were significantly associated with bothersome LUTS. Neurourol. Urodynam. 29:354–358, 2010. © 2009 Wiley‐Liss, Inc.
Schur complement of general H‐matrices
Authors: Bru R. , Corral C. , Giménez I. , Mas J. 
Published: September 2009

AbstractIt is well known that the Schur complement of some H‐matrices is an H‐matrix. In this paper, the Schur complement of any general H‐matrix is studied. In particular, it is proved that the Schur complement, if it exists, is an H‐matrix and the class to which the Schur complement belongs is studied. In addition, results are given for singular irreducible H‐matrices and for the Schur complement of nonsingular irreducible H‐matrices. Copyright © 2009 John Wiley & Sons, Ltd.
A posteriori error analysis of nonconforming finite volume elements for general second‐order elliptic PDEs
Authors: Yang Min 
Published: September 2009

AbstractIn this article, we study the a posteriori H1 and L2 error estimates for Crouzeix‐Raviart nonconforming finite volume element discretization of general second‐order elliptic problems in ℝ2. The error estimators yield global upper and local lower bounds. Finally, numerical experiments are performed to illustrate the theoretical findings. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2011
Detection of residual B precursor lymphoblastic leukemia by uniform gating flow cytometry
Authors: Mejstříková Ester , Froňková Eva , Kalina Tomáš , Omelka Marek , Batinić Drago , Dubravčić Klara , Pospíšilová Klára , Vášková Martina , Luria Drorit , Cheng Suk Hang , Ng Margaret , Leung Yonna , Kappelmayer Janos , Kiss Flora , Izraeli Shai , Stark Batia , Schrappe Martin , Trka Jan , Starý Jan , Hrušák Ondřej 
Published: September 2009

AbstractBackgroundResidual disease (RD) is an important prognostic factor in acute lymphoblastic leukemia (ALL). Flow cytometry (FC)‐based RD detection is easy to perform, but interpretation requires expert analysis due to individual differences among patients.ProcedureWe focused at the design of standardized and reproducible RD monitoring in ALL. RD was investigated by a uniform gating strategy, which was designed internationally and tested in one center by Ig/TCR rearrangements.ResultsFor each gate, positivity cutoff value was assigned using quantification of non‐leukemic background. Comparing to Ig/TCR at 0.1% level, 80 of 103 specimens were correctly diagnosed by FC. The predictive value of FC RD at day 15 was then analyzed. In B lineage ALL, day 15 FC significantly correlated with Ig/TCR results at day 33 and/or week 12 (P < 0.01). No significant correlation was found in T lineage ALL.ConclusionsThus, FC with preset uniform gating at day 15 predicts PCR‐detectable MRD in B precursor ALL. Presented data may be used to define new polychromatic cytometric diagnostics of MRD including semiautomatic assessment. Pediatr Blood Cancer 2010; 54:62–70. © 2009 Wiley‐Liss, Inc.
Successful radiation therapy for supratentorial primitive neuroectodermal tumor and epidermolysis bullosa simplex
Authors: Bavishi Sejal , Wong Kenneth , Delgardo Thamani , Marachelian Araz , Khatua Soumen 
Published: September 2009

AbstractEpidermolysis bullosa simplex (EBS) is a heritable skin disorder characterized by skin fragility and blistering. While its most severe variant, dystrophic epidermolysis bullosa (DEB) is associated with squamous cell carcinoma (SCC), the development of extracutaneous neoplasms in EBS is extremely rare. We report a novel case of supratentorial primitive neuroectodermal tumor (sPNET) in a 7‐year male with EBS. Experience of radiation therapy and its challenges in children with EBS has rarely been reported. Pediatr Blood Cancer 2010; 54:170–172. © 2009 Wiley‐Liss, Inc.
Nanoclay‐reinforced syntactic foams: Flexure and thermal behavior
Authors: Saha Mrinal C. , Nilufar Sabrina 
Published: September 2009

AbstractSyntactic foams containing 60 vol% of hollow glass microballoons in epoxy matrix are modified with untreated nanoclays using combined mechanical and ultrasonication methods. Effects of nanoclays on flexure and thermal behavior of syntactic foams are investigated by adding different amount of nanoclays in the range of 1–3% by weight. Microscopic examinations and physical property characterization are performed to determine the interactions among constituent materials and the void formation during fabrication. It is found that the syntactic foams with 2 wt% nanoclays show the highest improvement in flexural properties (∼42% strength and ∼18% modulus) and dynamic mechanical properties (∼30% storage modulus and ∼28% loss modulus) properties. Thermal decomposition temperature is found to be unaffected by the addition of nanoclays, whereas a continuous reduction in the coefficient of thermal expansion (CTE) is observed. An examination of failure surface indicates that the failure is initiated on the tension side of the flexure sample due to fracturing of microballoons. POLYM. COMPOS., 31:1332–1342, 2010. © 2009 Society of Plastics Engineers
Thermal and thermo‐oxidative degradation study of a model LDPE/EVA based TPE system: Effect of nano silica and electron beam irradiation
Authors: Hui S. , Chattopadhyay S. , Chaki T. K. 
Published: September 2009

AbstractThe effect of nano‐silica on the thermal degradation behavior of Low density polyethylene‐poly(ethylene‐ co‐vinyl acetate) (LDPE‐EVA) based thermoplastic elastomeric (TPE) system was monitored using thermo gravimetric analysis (TGA) in nitrogen and oxygen atmospheres (air), respectively. The pristine nano silica was melt‐blended with the LDPE‐EVA system at different loadings by varying the sequence of addition. In one of the compositions, coupling agent (Si69) was used. In nitrogen, thermal stability of such systems remained unchanged. However, in oxygen atmosphere, the TGA thermograms reflected a dramatic change. A two staged degradation was observed for all the samples. The enhancement in thermal stability particularly upto the low conversion levels was interpreted in terms of the barrier effect of silica particles on the O2 flow into the sample. The activation energies of degradation up to lower range of conversions were determined by nonisothermal and isothermal kinetic analyses. These were found to register a similar trend for various systems studied. Upon electron beam irradiation of such filled LDPE/EVA systems at controlled doses (20 and 40 kGy), the thermal stabilities were enhanced marginally. Overall, the thermal stabilities of the TPE nanocomposites are the function of sequence and extent of nano silica addition, presence of coupling agent and extent of irradiation. POLYM. COMPOS., 31:1387–1397, 2010. © 2009 Society of Plastics Engineers
Combined Continuous Wave and Pulsed Plasma Modes: For More Stable Interfaces with Higher Functionality on Metal and Semiconductor Surfaces
Authors: Li Li , Dai Xiujuan J. , Xu Hong S. , Zhao Jing H. , Yang Ping , Maurdev George , du Plessis Johan , Lamb Peter R. , Fox Bronwyn L. , Michalski Wojtek P. 
Published: September 2009

AbstractA novel approach to producing improved bio‐interfaces by combining continuous wave (CW) and pulsed plasma polymerization (PP) modes is reported. This approach has enabled the generation of stable interfaces with a higher density of primary amine functionality on metal, ceramic and semiconductor surfaces. Heptylamine (HA) was used as the amine‐precursor. In this new design, a thin CW PPHA layer is introduced to provide strong cross‐linking and attachment to the metal or semiconductor surfaces and to provide a good foundation for better bonding a pulsed PPHA layer with high retention of functional groups. The combined mode provides the pulsed mode advantage of a 3‐fold higher density of primary amines, while retaining much of the markedly higher stability in aqueous solutions of the continuous mode.magnified image
Trp fluorescence reveals an activation‐dependent cation‐π interaction in the Switch II region of Gαi proteins
Authors: Hamm Heidi E. , Meier Scott M. , Liao Guihua , Preininger Anita M. 
Published: September 2009

AbstractCrystal structures of Gαi (and closely related family member Gαt) reveal much of what we currently know about G protein structure, including changes which occur in Switch regions. Gαt exhibits a low rate of basal (uncatalyzed) nucleotide exchange and an ordered Switch II region in the GDP‐bound state, unlike Gαi, which exhibits higher basal exchange and a disordered Switch II region in GαiGDP structures. Using purified Gαi and Gαt, we examined the intrinsic tryptophan fluorescence of these proteins, which reports conformational changes associated with activation and deactivation of Gα proteins. In addition to the expected enhancement in tryptophan fluorescence intensity, activation of GαGDP proteins was accompanied by a modest but notable red shift in tryptophan emission maxima. We identified a cation‐π interaction between tryptophan and arginine residues in the Switch II of Gαi family proteins that mediates the observed red shift in emission maxima. Furthermore, amino‐terminal myristoylation of Gαi resulted in a less polar environment for tryptophan residues in the GTPase domain, consistent with an interaction between the myristoylated amino terminus and the GTPase domain of Gα proteins. These results reveal unique insights into conformational changes which occur upon activation and deactivation of G proteins in solution.
SRD5A2 V89L polymorphism and prostate cancer risk: A meta‐analysis
Authors: Wang Chunyang , Tao Weiyang , Chen Qiyin , Hu Hailong , Wen Xiao‐Yan , Han Ruifa 
Published: September 2009

AbstractBACKGROUNDIncreasing studies investigating the association between steroid 5‐alpha reductase type II gene polymorphism at codon 89 (SRD5A2 V89L) and susceptibility to prostate cancer (PCa) confer inconsistent results. To precisely estimate the relationship with more statistical power, a meta‐analysis was performed.METHODSA comprehensive search was conducted to identify all case–control studies investigating such an association. Odds ratio (OR) and its 95% confidence interval (CI) were used to evaluate the size effect.RESULTSTwenty‐five eligible reports were identified including 8,615 cases/9,089 controls in 33 comparisons. In overall analysis, no significant associations were found in all genetic models. Subgroup analyses by ethnicity revealed that small excess PCa risks were observed in dominant model (OR, 1.11; 95% CI, 1.03–1.19 for (LL + VL) vs. VV; P < 0.01; Pheterogeneity = 0.49) and L allele frequency comparison (OR, 1.09; 1.03–1.15 for L allele frequency; P < 0.01; Pheterogeneity = 0.07) in Europeans. Meanwhile, SRD5A2 V89L polymorphism was significantly associated with an increased PCa risk in men aged ≤65 under the co‐dominant (OR, 1.70; 95% CI, 1.09–2.66 for LL vs. VV; P = 0.02; Pheterogeneity = 0.31) and recessive (OR, 1.75; 95% CI, 1.14–2.68 for LL vs. (VV + VL); P = 0.01; Pheterogeneity = 0.12) models. However, no significant associations were found in Asians and Africans.CONCLUSIONSOur study suggests SRD5A2 V89L polymorphism could play a low‐penetrant role in PCa risk among Europeans and individuals younger than 65 years. Additional well‐designed studies are warranted to validate these findings. Prostate 70: 170–178, 2010. ©2009 Wiley‐Liss, Inc.
The effect of Pr6O11 doping on superconducting properties of MgB2
Authors: Ojha N. , Malik V. K. , Bernhard C. , Varma G. D. 
Published: September 2009

AbstractIn this paper we report the effect of Pr6O11 doping on the structural and superconducting properties of MgB2. The bulk samples of Pr6O11‐doped MgB2 have been prepared with nominal compositions Mg1−x(Pr6O11)x/6B2 (where x = 0.0, 0.01, 0.02, 0.03, 0.04, and 0.05) via a standard solid‐state reaction route by sintering in a reducing atmosphere of Ar/H2. The superconducting transition temperature Tc of MgB2 is found to decrease from 39 to 37 K when x increases from 0 to 0.05. The XRD results show the presence of MgO and PrB6 secondary phases in the doped samples besides the main hexagonal phase of MgB2. Improvement in critical current density (Jc), irreversibility field (Hirr), and upper critical field (Hc2) of doped samples has been observed. The Jc values at 10 and 20 K of the x = 0.03 sample are higher in the entire field region (0–6 T). At 10 K and 2 T field the Jc values of undoped and 0.03 Pr6O11‐doped samples are 1.09 × 105 and 2.21 × 105 A/cm2, respectively. Variations of Hc2, Jc, Hirr, and flux‐pinning force (Fp) with doping concentrations have been studied in this paper and a correlation between these superconducting properties and structural characteristics of the samples has been found in the present work.
Resonating coupled‐cluster CI approach to ion‐radical systems: Comparison with the unrestricted coupled‐cluster approach
Authors: Yamanaka S. , Nishihara S. , Nakata K. , Yonezawa Y. , Okumura M. , Takada T. , Nakamura H. , Yamaguchi K. 
Published: September 2009

AbstractWe implemented the resonating configuration interaction (Res‐CI) approach with spin‐unrestricted coupled‐cluster (UCC) solutions as basis for ion‐radical systems. In previous studies (Nishihara et al., Int J Quantum Chem 2008, 108, 2966; Nishihara et al., J Phys: Condens Matt 2009, 21, 064227), we showed that it is possible to satisfy an important condition proposed by Perdew et al. using Res‐CI based on two complementary spin‐unrestricted Hartree–Fock solutions. In this study, we extended the method to Res‐CI calculations based on UCC solutions (Res‐CC CI) for simple ion‐radical systems, which is to our knowledge, a new type of ab initio method. We examined the asymmetric effects on whether the hole (or the excess electron) localizes at one site or delocalizes over two sites. The computational results of Res‐CC CI are compared with those of UCC, and the implications are discussed. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2009
Spatial and temporal tree colonization in a midstream sediment bar and the mechanisms governing tree mortality during a flood event
Authors: Asaeda Takashi , Gomes Pattiyage I. A. , Takeda Eisuke 
Published: September 2009

AbstractReduced disturbances in regulated rivers can result in stable tree colonisation in downstream reaches. We examined spatial and temporal tree colonisation on a midstream sediment bar, focussing on three dominant taxa:Salixspp. (primarilySalix gilgiana),Robinia pseudoacaciaandAlbizia julibrissin. We developed allometric relationships for tree height, tree age and tree diameter at breast and knee height, as well as relationships between above and below‐ground biomass. The spatial profiles for all individual trees of these taxa were obtained before and after a major flood in September 2007. Pre‐flood data indicate thatR. pseudoacaciacolonize the highest elevations,A. julibrissinlower elevations andSalixspp. the lowest elevations of the three taxa. The oldest trees at each elevation were found to have survived 1.8–2.5 m inundation in past floods. Results of investigations subsequent to the flood event in September 2007 suggest that trees can survive flooding as long as their roots remain embedded in the soil. Individuals ofSalixspp. experienced higher levels of inundation, but showed the greatest survival. This is probably due to morphological acclimations, particularly deep root systems and high elasticity of shoots. Considering inundation depths, erosion depths and sediment particle sizes in tree habitats, we found that sediment mobilization was the major cause of tree mortality. Thus, the ability ofSalixspp. to colonize coarse sediments greatly contributed to its survival, as coarse sediments result in significantly less tractive force. Copyright © 2009 John Wiley & Sons, Ltd.
Modelling criteria for r/c elements constructed with ultra‐high‐strength concrete and subjected to cyclic loading
Authors: Elmenshawi Abdelsamie , Brown Tom 
Published: September 2009

AbstractHigh‐strength concrete (HSC) has several benefits in high‐rise concrete buildings; however, its structural use in active seismic regions may be questioned due to the lower ductility of such concretes. In addition, seismic macro‐models being used currently are based on R/C elements constructed with normal‐strength concretes (f ≤ 40 MPa (5.8 ksi)). In this paper, the performance of plastic hinges in flexural elements constructed with a concrete strength up to 175 MPa (25.4 ksi) is investigated. In addition, other variables were studied such as the sectional reinforcement asymmetry, hinge shear strength and hinge shear demand. The seismic performance is presented in terms of stiffness deterioration, strength degradation, pinching phenomenon and displacement ductility. The requirements to implement the use of HSC in current macro‐models are examined. Current hysteretic models may be used to evaluate structural components constructed with higher concrete strength; however, the influence of concrete strength is controlled by the other test variables. Copyright © 2009 John Wiley & Sons, Ltd.
Tributyltin causes obesity and hepatic steatosis in male mice
Authors: Zuo Zhenghong , Chen Shuzhen , Wu Tian , Zhang Jiliang , Su Ying , Chen Yixin , Wang Chonggang 
Published: September 2009

AbstractOrganotin compounds such as tributyltin (TBT) have been used worldwide in agriculture and industry as biocides, heat stabilizers, and chemical catalysts. However, few studies addressing the effects of TBT on growth and metabolism have been reported. This study was conducted to investigate the effects of TBT at low doses (0.5, 5, and 50 μg/kg) on body weight gain in male mice exposed as from puberty and to determine the alterations in related hormones. The results showed that exposure to TBT for 45 days resulted in an increase in body weight gain and hepatic steatosis accompanied with hyperinsulinemia and hyperleptinemia. Reduction of hepatic adiponectin levels in a dose‐dependent manner was related to the lipid increase in the liver. These results suggest that chronic and repeat exposure to low doses of TBT can result in obesity and hepatic steatosis and induce the occurrence of insulin and leptin resistance. © 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 79–85, 2011.