bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pilot study of botulinum toxin for interstitial cystitis/painful bladder syndrome
Authors: Gottsch Henry P. , Miller Jane L. , Yang Claire C. , Berger Richard E. 
Published: June 2010

AbstractObjectivesPreliminary studies using botulinum toxin (BTX) have demonstrated some benefits in treating interstitial cystitis (IC)/painful bladder syndrome (PBS) pain. The purpose of this study was to investigate the efficacy of a periurethral injection of BTX to block urethral visceral and somatic afferent fibers, for the treatment of IC/PBS.MethodsTwenty adult women with IC/PBS were identified from the Female Urology Clinic at our hospital. Symptom evaluation was performed using a female modification of the Chronic Prostatitis Symptom Index (CPSI), AUA Symptom Index, Graded Chronic Pain Scale, Perceived Stress Scale, and symptom improvement Visual Analog Scale (VAS). All patients were randomized to receive either botulinum toxin A (BTX‐A) or placebo (normal saline). Patients randomized to BTX‐A received 50 U diluted in 2 cm3 normal saline injected periurethrally. The physician and patient were blinded to the treatment.ResultsBTX was administered to nine women. There were no complications or side effects reported. There was no improvement between placebo and BTX‐A groups in the CPSI score at 3‐month follow‐up (P = 0.97). Additionally, there were no improvements in the other symptom indices. At follow‐up, the mean VAS for the BTX group was −0.3, indicating the subjects' symptoms were the same as at the start of the study.ConclusionsPeriurethral injection of botulinum toxin in women did not effectively treat the pain of IC/PBS. While the results from this study are negative, there is still a valid rationale for further investigations of novel injection protocols given the dearth of current effective treatments. Neurourol. Urodyn. 30:93–96, 2011. © 2010 Wiley‐Liss, Inc.
Effects of thoracic epidural analgesia on lower urinary tract function in women
Authors: Wuethrich Patrick Y. , Burkhard Fiona C. , Panicker Jalesh N. , Kessler Thomas M. 
Published: June 2010

AbstractAims: The need for an indwelling transurethral catheter in patients with postoperative thoracic epidural analgesia (TEA) is a matter of controversy. Subjective observations are ambivalent and the literature addressing this issue is scarce. As segmental blockade can be achieved with epidural analgesia, we hypothesized that analgesia within segments T4–T11 has no or minimal influence on lower urinary tract function. Thus, we evaluated the effect of TEA on lower urinary tract function by urodynamic studies. Methods: In 13 women with no preoperative lower urinary tract symptoms undergoing open kidney surgery by lumbotomy under TEA, we prospectively assessed changes in urodynamic parameters the day before and 2–3 days after surgery with the patients under TEA. Results: Before versus during TEA, there was a significant increase in postvoid residual (median, 5 ml vs. 220 ml, P < 0.001) and a significant decrease in maximum detrusor pressure (median, 23 cmH2O vs. 5 cmH2O, P = 0.001), detrusor pressure at maximum flow rate (median, 18 cmH2O vs. 5 cmH2O, P = 0.001), maximum flow rate (median, 12 ml/sec vs. 3 ml/sec, P < 0.001), and voided volume (median, 250 ml vs. 40 ml, P < 0.001). In addition, maximum urethral closure pressure at rest decreased significantly under TEA from median 75 cmH2O to 56 cmH2O (P = 0.002). Bladder sensation, maximum cystometric capacity, compliance, and functional profile length at rest were not influenced by TEA. Conclusions: TEA has a significant effect on bladder emptying with clinically relevant postvoid residual (PVR) necessitating (indwelling or intermittent) catheterization or monitoring of PVR. Neurourol. Urodyn. 30:121–125, 2011. © 2010 Wiley‐Liss, Inc.
Independent spanning trees on folded hyper‐stars
Authors: Yang Jinn‐Shyong , Chang Jou‐Ming 
Published: June 2010

AbstractFault‐tolerant broadcasting and secure message distribution are important issues for numerous applications in networks. It is a common idea to design multiple independent spanning trees (ISTs) as a broadcasting scheme or a distribution protocol for receiving high levels of fault‐tolerance and security. Recently, hyper‐stars were introduced as a competitive model of interconnection network for both hypercubes and star graphs. The class of folded hyper‐stars is a strengthened variation of hyper‐stars obtained by adding additional links to connect complemented nodes. Both hyper‐stars and folded hyper‐stars have been shown to have lower network cost (measured by the product of degree and diameter) than hypercubes, folded hypercubes, and other variants. In this article, we propose an algorithm to construct k + 1 ISTs on a regular folded hyper‐star FHS (2k,k), where the number of ISTs matches the connectivity of FHS(2k,k). In particular, for k > 4, the constructed k ISTs have height 2 k − 2, and the other one has height k + 1. © 2010 Wiley Periodicals, Inc. NETWORKS, 2010
Increased prevalence of risk factors for cardiovascular disease in long‐term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy
Authors: Geenen M.M. , Bakker P.J.M. , Kremer L.C.M. , Kastelein J.J.P. , Leeuwen F.E. van 
Published: June 2010

AbstractBackgroundOnly a few studies have assessed cardiovascular risk factors (CRFs) in childhood cancer survivors. We determined the prevalence of CRFs in long‐term survivors of acute lymphoblastic leukemia (ALL) and Wilms tumor.ProcedureAdult survivors of ALL and Wilms tumor treated with radiotherapy and chemotherapy (RT + CT) or treated with chemotherapy alone (CT) were compared with sibling controls. CRFs (hypertension, diabetes mellitus, hypercholesterolemia, obesity, renal insufficiency) and hormonal deficiencies were assessed in each participant. Multivariate logistic regression analysis was used to evaluate the association between CRFs and treatment.ResultsSeventy‐nine ALL, 62 Wilms tumor survivors, and 69 control subjects (mean ages 24.5, 25.9, and 26 years, respectively) were enrolled. Mean follow‐up time since cancer treatment was 20.8 years. In the Wilms RT + CT group significantly more survivors had hypertension (21.6% vs. 1.4%, P < 0.001) and renal insufficiency (8.1% vs. 0%, P = 0.016) compared to controls. There were also more patients with multiple CRFs in the Wilms RT + CT group (16.2% vs. 2.9% in controls, P = 0.019). Almost 15% of ALL RT + CT survivors had growth hormone deficiency. Hypogonadism was seen in 18.9% of survivors in the Wilms RT + CT group. We observed no significant differences between CT‐treated survivors of both malignancies and controls. The adjusted odds ratio for the occurrence of at least one CRF was 2.6 increased for survivors following abdominal radiotherapy. Treatment with CT alone was not associated with the occurrence of multiple CRFs.ConclusionsLong‐term survivors of ALL and Wilms tumor have unfavorable CRFs due to previous RT not CT. Pediatr Blood Cancer. 2010;55:690–697. © 2010 Wiley‐Liss, Inc.
Refractory dilated cardiomyopathy associated with metastatic neuroblastoma
Authors: Carlson Peter , Jefferies John L. , Kearney Debra , Russell Heidi 
Published: June 2010

AbstractA 2‐year‐old African American male presented with heart failure and an abdominal mass. Computerized tomography (CT) scan revealed a 7 cm adrenal lesion, confirmed as poorly differentiated neuroblastoma (NB). CT and meta‐iodobenzoguanidine (MIBG) scans identified multiple metastases, but cardiac MIBG imaging was absent. Cardiac ejection fraction (EF) was 8% with 7% shortening fraction. The patient underwent six cycles of chemotherapy and investigational immunotherapy. Cardiac function improved to 26% EF. However, the tumor proved unresponsive to treatment. The patient died from stage IV congestive heart failure (CHF) and progressive NB. Autopsy confirmed dilated cardiomyopathy with endocardial fibroelastosis. Pediatr Blood Cancer. 2010;55:736–738. © 2010 Wiley‐Liss, Inc.
Development of secondary T‐cell acute lymphoblastic leukemia in a child with hemophagocytic lymphohistiocytosis
Authors: Shamsian Bibi Shahin , Gharib Atoosa , Rezaei Nima , Esfahani Shadi Abdar , Alavi Samin , Goudarzipour Kourosh , Arzanian Mohammad Taghi 
Published: June 2010

AbstractHemophagocytic lymphohistiocytosis (HLH) is a severe life‐threatening disorder, characterized by hyperactivation of macrophages. A 12‐year‐old female was referred to our center; the diagnosis of HLH was made for the patient and immunosuppressive regimen was started. After a 2‐year follow‐up, the patient developed secondary T‐cell acute lymphoblastic leukemia (T‐ALL), confirmed by flow cytometric studies. Treatment was started based on T‐ALL protocol, but the patient died because of relapse and sepsis. This case highlights the issue of secondary malignancy following HLH and demonstrates the need for continued follow‐up in such patients. Pediatr Blood Cancer. 2010;55:725–726. © 2010 Wiley‐Liss, Inc.
Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors: A children's oncology group study
Authors: George Rani E. , Lahti Jill M. , Adamson Peter C. , Zhu Kejin , Finkelstein David , Ingle A. Mark , Reid Joel M. , Krailo Mark , Neuberg Donna , Blaney Susan M. , Diller Lisa 
Published: June 2010

AbstractBackgroundDemethylating agents may alter the expression of genes involved in chemotherapy resistance. We conducted a phase I trial to determine the toxicity and molecular effects of the demethylating agent, decitabine, followed by doxorubicin and cyclophosphamide in children with refractory solid tumors.ProcedureStratum A included children with any solid tumor; Stratum B included neuroblastoma patients only. Patients received a 1‐hr decitabine infusion for 7 days, followed by doxorubicin (45 mg/m2) and cyclophosphamide (1 g/m2) on day 7. Pharmacokinetic studies were performed after the first dose of decitabine. Biological studies included methylation and gene expression analyses of caspase‐8, MAGE‐1 and fetal hemoglobin (HbF), and expression profiling of pre‐ and post‐treatment peripheral blood and bone marrow cells.ResultsThe maximum‐tolerated dose of decitabine was 5 mg/m2/day for 7 days. Dose‐limiting toxicities at 10 mg/m2/day were neutropenia and thrombocytopenia. Decitabine exhibited rapid clearance from plasma. Three of 9 patients in Stratum A and 4/12 patients in Stratum B had stable disease for ≥4 months. Sustained MAGE‐1 demethylation and increased HbF expression were observed in the majority of patients post‐treatment (12/20 and 14/16, respectively). Caspase‐8 promoter demethylation and gene expression were seen in 2/7 bone marrow samples. Differentially expressed genes were identified by microarray analysis.ConclusionLow‐dose decitabine when combined with doxorubicin/cyclophosphamide has tolerable toxicity in children. However, doses of decitabine capable of producing clinically relevant biologic effects were not well tolerated with this combination. Alternative strategies of combining demethylating agents with non‐cytotoxic, biologically targeted agents such as histone deactelyase inhibitors should be explored. Pediatr Blood Cancer. 2010;55:629–638. © 2010 Wiley‐Liss, Inc.
Matched unrelated umbilical cord blood transplantation for a patient with chemotherapy resistant Wilms tumor
Authors: Lucas Kenneth G. , Shapiro Terry , Freiberg Andrew , Frauenhoffer Elizabeth 
Published: June 2010

AbstractWe report a patient with chemotherapy refractory Wilms tumor who underwent an unrelated donor cord blood transplant for chemotherapy refractory disease. The preparative regimen consisted of busulfan, melphalan, and anti‐thymocyte globulin, and was well tolerated. This patient did not experience significant toxicity related to the chemotherapy regimen and did not develop any graft versus host disease from his HLA (A, B, DR) 6/6 matched cord blood transplant. Follow‐up CT scans 2 years post‐transplant have shown no evidence of disease progression, with only a few pulmonary nodules remaining, which are unchanged in size from his pre‐transplant CT scan. It is possible that high‐dose chemotherapy and stem cell transplantation can be curative in patients with tumors that are non‐responsive to conventional chemotherapy. Pediatr Blood Cancer. 2010;55:763–765. © 2010 Wiley‐Liss, Inc.
Traditional laboratory measures of cardiovascular risk in hereditary spherocytosis
Authors: Crary Shelley E. , Troendle Sarah , Ahmad Naveed , Buchanan George R. 
Published: June 2010

AbstractBackgroundIndividuals who have undergone splenectomy may be at an increased risk of arterial and venous thrombosis. We sought to determine if splenectomy affects surrogate laboratory measures of cardiovascular risk in persons with hereditary spherocytosis (HS).ProcedureWe conducted a prospective cross‐sectional study of 21 children and 36 adults with HS. Fasting blood samples were collected for complete blood count and plasma lipid panel, homocysteine, lipoprotein (a), C‐reactive protein, and fibrinogen. The variables were compared between the groups with and without prior splenectomy by Mann–Whitney tests.ResultsSubjects with prior splenectomy had higher hemoglobin, white blood cell and platelet counts and lower reticulocyte counts and total serum bilirubin concentrations (P < 0.001). Subjects not having had splenectomy had lower than normal levels of total and LDL‐cholesterol (LDL‐C). Total and LDL‐C values were significantly higher, as were fibrinogen and homocysteine concentrations, in the post‐splenectomy subjects than in individuals with intact spleen.ConclusionVarious lipid levels and other measures of cardiovascular risk are affected by splenectomy in persons with HS. Further investigations are indicated to more clearly define the balance of the potential benefits of hemolysis and anemia versus the deleterious effects of splenectomy in HS. Pediatr Blood Cancer. 2010;55:684–689. © 2010 Wiley‐Liss, Inc.
Acquired hemophilia in pediatrics: A systematic review
Authors: Franchini Massimo , Zaffanello Marco , Lippi Giuseppe 
Published: June 2010

AbstractAcquired hemophilia A is a rare but potentially life‐threatening hemorrhagic disorder caused by the development of autoantibodies directed mostly against coagulation factor VIII. Acquired hemophilia is frequently associated with several underlying conditions such as malignancy, autoimmune disorders, drug reactions, and pregnancy, although the pathogenesis remains undetermined (idiopathic) in up to 50% of reported cases. The disorder occurs most commonly in the elderly and only rarely affects pediatric patients, who might however experience severe, and sometimes life‐threatening, hemorrhage. The maternal transplacental transfer of the autoantibody to the neonate occurs very rarely and also in this circumstance it may be associated with clinically significant bleeding. The management of acute bleeding and the inhibitor eradication are the mainstay of the treatment. The outcome in pediatric patients seems more favorable than in adults because the inhibitors usually resolve more quickly and in a higher rate of patients. The epidemiology, diagnosis, clinical course, and management of this hemorrhagic disorder in children will be addressed in this systematic review. Pediatr Blood Cancer. 2010;55:606–611. © 2010 Wiley‐Liss, Inc.
Spielerisches Bimetall. Spielwiese
Authors: Ucke Christian , Schlichting Hans Joachim 
Published: June 2010

AbstractBimetalle sind technisch weit verbreitet und finden in Thermometern und als Schalter vielfältig Verwendung. Bei der Klickscheibe und der Lichtwippe wird ein Bimetall in spielerischer Form eingesetzt. Ein Klangobjekt mit Bimetallantrieb ist ein eher künstlerisches Beispiel.
Auftrieb durch Wasser und Wind. Physik des Segelns
Authors: Scheer Elke 
Published: June 2010

AbstractPhysikalisch gesehen ist Segeln ein dynamisches Zusammenspiel verschiedener Kräfte. Entscheidend sind die Auftriebskräfte über und unter Wasser. Über Wasser gibt die anströmende Luft dem Segel ein Profil, das daraufhin wie ein Flügel wirkt. Unter Wasser sorgt das um das Profil der Kielflosse strömende Wasser für eine Gegenkraft. Da mit Luft und Wasser zwei hydrodynamisch sehr verschiedene Fluide das Segeln bestimmen, ist das Zusammenspiel beider Kräfte physikalisch komplex. Es erlaubt Segeln in einem großen Winkelbereich relativ zum Wind – außer direkt gegen ihn.
Turbulenz verbessert Quantenkommunikation
Authors: Semenov Andrew A. , Vogel Werner 
Published: June 2010

AbstractEiner Forschungsgruppe um Anton Zeilinger in Wien gelang es im letzten Jahr, verschränkte Photonen über eine Distanz von 144 km durch die turbulente Atmosphäre zu übertragen. In einer theoretischen Arbeit konnten wir jetzt zeigen, dass Turbulenz in der Atmosphäre die Transmission sogar verbessert. Dies ist für Anwendungen in der Quantenkommunikation von Bedeutung.
Präzisionsmessung der Gravitations‐Rotverschiebung
Authors: Müller Holger , Peters Achim 
Published: June 2010

AbstractNach der Allgemeinen Relativitätstheorie verlangsamt die Schwerkraft den Ablauf der Zeit. Diese Vorhersage konnten Wissenschaftler aus Berkeley, Berlin und Washington, D.C. mit einem Atominterferometer an der Stanford University bis auf 7 · 10–9 bestätigen. Es ist damit der bislang genaueste Test der Gravitations‐Rotverschiebung.
Von der Hydro‐ zur Aerodynamik
Authors: Junk Andreas 
Published: June 2010

AbstractEiner der Pioniere bei der Visualisierung von Turbulenzen in laminaren Strömungsgebieten war der Göttinger Forscher Ludwig Prandtl, dessen Wirken in der Hydro‐ und Aerodynamik sich auf mehr als ein halbes Jahrhundert erstreckt. Er legte mit seinen Forschungsmethoden und ‐resultaten Grundlagen, in deren Tradition sich die Hydro‐ und Aerodynamiker bei der Modellierung moderner Tragflächen oder Schiffsrümpfe bis heute bewegen.
Warum können große Vögel nicht fliegen?
Authors: Rolfs Claus 
Published: June 2010

AbstractEin Mathematiker hat angeblich einmal bewiesen, dass Hummeln nicht fliegen können. Doch aller Theorie zum Trotz tun sie es. Aber sehr schwere Vögel wie Truthähne oder Strauße können sich wirklich nicht in die Lüfte erheben. Der Grund ist letztlich eine nicht ausreichende Energieproduktion der Körper.
Der Salonphysiker
Authors: Loos Andreas 
Published: June 2010

AbstractEigentlich wollte er Chirurg werden. Wäre da nicht das viele Blut gewesen. So verlegt er sich auf die Physik, die er allerdings anfangs eher als Hobby betreibt. Ein Freund sagt über ihn: “Er führt sozusagen das Leben einer dieser Katzen aus gutem Hause, die sich auf dem besten Platz im Schlafzimmer oder im Salon niederlassen. Wenn Besuch kommt, der ihm nicht behagt, zieht er sich in seinen Winkel zurück, mit seinem Notizbuch und seinem Bleistift, den er immer bei sich hat.” Doch dieser Salonphysiker soll in die Geschichte eingehen.
Kalte Baisers – Schäume unter Temperaturschock
Authors: Vilgis Thomas 
Published: June 2010

AbstractSüße Schäume aus Eiklar, Baisers, gehören zu den beliebtesten Kindheitserinnerungen aller Naschkatzen. Das Trocknen dieser Gebilde aus schaumig geschlagenem Eiklar mit Zucker bei 100 °C führt auf die brüchig staubigen und süßen, im Mund zergehenden Knusprigkeiten. Baisers kann man aber auch – eines Physikers würdig – in flüssigem Stickstoff bei – 196°C herstellen. Nur die Physik der Schäume lässt das Arbeiten in diesen riesigen Temperaturbereichen zu.
New perspectives on polyhedral molecules and their crystal structures
Authors: Alvarez Santiago , Echeverría Jorge 
Published: June 2010

AbstractRelevant families of ideal polyhedra (Platonic, Archimedean, prisms, Johnson, and Fullerenes) are briefly summarized, and an overview of polyhedral alkanes and alkenes, existing or hypothetical, is presented. The assignment of a polyhedral shape to a specific compound with the help of continuous shape measures and derived tools is also briefly discussed, and application of shape analysis to cyclic molecules such as cyclobutane, cyclohexane, and cyclooctatetraene is presented to illustrate the usefulness of ideal polyhedra in the stereochemical description of non‐polyhedral molecules. Finally, the presence of latent octahedral symmetry in icosahedral polyhedra is used to design new molecules with nested shells of the two supposedly incompatible symmetries, and to explain the cubic crystal structures of icosahedral molecules such as dodecahedrane and Buckminsterfullerene. Copyright © 2010 John Wiley & Sons, Ltd.
Spontaneous oscillatory in vitro chiral conversion of simple carboxylic acids and its possible mechanism
Authors: Sajewicz Mieczysław , Matlengiewicz Marek , Leda Marcin , Gontarska Monika , Kronenbach Dorota , Kowalska Teresa , Epstein Irving R. 
Published: June 2010

AbstractIn earlier studies, we have collected experimental evidence (mostly from thin‐layer chromatography and polarimetry) on the spontaneous oscillatory in vitro chiral conversion of simple carboxylic acids dissolved in 70% aqueous ethanol. To elucidate this phenomenon, we developed a simple theoretical model of two linked Templators. Recently, we have obtained additional experimental evidence of the spontaneous condensation of chiral carboxylic acids, based on the biuret test (amino acids), high performance liquid chromatography, and 13C NMR spectroscopy (profens and hydroxy acids). We briefly describe our experimental results in the context of the existing literature and outline an improved theoretical model for these phenomena. Our system resembles in some respects the reported oscillatory condensation of organic silanols. Here, the key reaction is the formation of carboxylic acid‐derived enols. Finally, we discuss the importance of the oscillatory chiral conversion of simple carboxylic acids for biochemistry, pharmacology, and related life sciences. Copyright © 2010 John Wiley & Sons, Ltd.
Redox, kinetics, and complexation chemistry of the CrVI/CrV/CrIV ‐D‐glycero‐D‐gulo‐heptono‐1,4‐lactone System
Authors: Mangiameli María F. , González Juan C. , García Silvia , Bellú Sebastián , Santoro Mabel , Caffaratti Evangelina , Frascaroli María I. , Peregrín Juan Manuel Salas , Atria Ana M. , Sala Luis F. 
Published: June 2010

AbstractWhen a 60‐times or higher excess of D‐glycero‐D‐gulo‐heptono‐1,4‐lactone (GHL) over CrVI is used, reaction yields D‐gluconic acid, formic acid and CrIII as final products. The redox reaction involves formation of intermediates, CrIV and CrV species, reacting with GHL at comparable rates. CrIV is a very reactive intermediate and does not accumulate during this reaction; its rate of disappearance is 2.0 × 104 and 4.0 × 103 times higher than CrVI or CrV reaction with GHL, respectively. Kinetic studies show that the redox reaction proceeds through a mechanism combining CrVI → CrIV → CrII and CrVI → CrIV → CrIII pathways. This mechanism is supported by the observation of free radicals, superoxoCrIII (CrO) and oxo‐CrV as intermediates species. Complete rate laws for the GHL/chromium redox reaction are described in the present work. EPR spectra show that five‐coordinate oxo‐CrV bischelates (giso1 = 1.9802; giso2 = 1.9803) are formed at pH ≤ 4 where the OH and O‐ring groups of GHL participate in the bonding to oxo‐CrV. Penta‐coordinated oxo‐CrV monochelates are observed as minor species (giso3 = 1.9866; giso4 = 1.9879) in addition to the major penta‐coordinated oxo‐CrV bischelates. Copyright © 2010 John Wiley & Sons, Ltd.