bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges with Newly Approved CRISPR Gene Technologies
Authors: Ahmed Sagheer 
Published: April 2024

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology is a powerful gene-editing tool that allows for precise modification of DNA. While CRISPR has shown immense potential in laboratory and preclinical studies, the development of CRISPR-based therapies for human use is still in the early stages. However, on December 08, the Food and Drug Administration (FDA) of the United States of America approved two milestone treatments, Casgevy and Lyfgenia, representing the first cell-based gene therapies for the treatment of sickle cell disease (SCD) in patients 12 years and older. Several CRISPR-Cas9 therapies that work on the same principle are in clinical trials as treatments for a range of diseases.
However, there are still significant concerns with the use of this new technology. One major concern with CRISPR technology is the potential for off-target effects, where unintended changes may occur in locations other than the target gene. The introduction of CRISPR components into the body may also trigger an immune response. Several laboratories are investigating ways to mitigate immune reactions and improve the delivery of CRISPR components. The method of delivering CRISPR components into cells is also important for safety. Further research into different delivery methods, such as viral vectors or nanoparticles, would help optimize efficiency while minimizing potential side effects.
The long-term effects of CRISPR-based interventions are an area of ongoing research. Understanding the stability of CRISPR-induced changes over time and potential consequences is crucial for assessing safety. Ethical considerations are important to discussions about CRISPR use, particularly when it comes to editing the human germline (sperm, eggs, embryos), as changes made in these cells would be heritable. The potential for unintended consequences and ethical implications necessitates careful consideration.
It is important to consider that although CRISPR holds great promise, the technology is relatively young, and research is ongoing to address safety concerns. The scientific community and regulatory bodies are actively working to ensure that CRISPR technologies are developed and implemented responsibly. Continuous advancements, ongoing research, and open communication will be essential to addressing safety challenges associated with CRISPR.
Atividade antimicrobiana da nanocelulose bacteriana contendo Caesalpinia ferrea
Authors: Alves Patrícia Lius Melo , Borba Machelle Watuse de , Machado Gabriel Pereira , Chacon Ana Carolina Souza , Simões Larissa Oliveira , Pickler Thaisa Borim , Grotto Denise , Jozala Angela Faustino 
Published: April 2024

A Caesalpinia ferrea (Libidibia ferrea), pertence à família Fabaceae, e popularmente conhecida como “Jucá”, vem sendo amplamente empregada para a cicatrização de feridas, devido indicação como anti-inflamatória e analgésica. A otimização da liberação dos compostos bioativos encontrados na Caesalpinia ferrea (C. ferrea) pode ser obtida por meio da aplicação da nanocelulose bacteriana (NCB). O presente estudo buscou avaliar a ação antimicrobiana do sistema nanocelulose bacteriana e extrato de C. ferrea (CAE). O extrato de C. ferrea foi incorporada às NCB’s por imersão. Após a incorporação foram avaliadas as concentrações de proteínas na solução de CAE, assim como, foram também avaliadas diferentes concentrações da C. ferrea quanto a sua atividade antimicrobiana utilizando a metodologia de difusão em ágar e concentração inibitória mínima com os seguintes microrganismos: Staphylococus aureus ATCC 10390 (Gram-positivo); Escherichia coli ATCC 25922, Pseudomonas aeuroginosa ATCC 9721 (Gram-negativos). De acordo com os resultados da análise de proteínas o maior pico de liberação feita pela NCB foi no período de 30 h, com um total de 218 μg/mL. Com relação a inibição do crescimento dos microrganismos testados, a CAE liberada pela NCB, seja em períodos de 2 h a 40 h, se demonstrou eficaz. O extrato de CAE reconstituído em PBS e CAE incorporado em NCB apresentaram atividade antimicrobiana para os patógenos Gram-positivos e Gram-negativos. Além disso foi observado que as características da NCB podem representar um novo e promissor sistema de entrega de biomoléculas.
Demarcações analíticas das políticas públicas para pessoas com deficiências em conjuntura brasileira: apontamentos para quebra de paradigmas capacitistas
Authors: Albuquerque Junior Ailton Batista de , Borges Maria Celia , Araújo Ana Cláudia Uchoa 
Published: April 2024

Quando nos propomos a debater a educação especial na perspectiva inclusiva trazemos à baila a urgência de valorização das diferenças em âmbito educacional, através da identificação de histórias, identidades e fatores culturas de povos foram historicamente secundarizados. Nesses termos, o artigo tem o objetivo de discutir a o alcance das políticas públicas inclusivas para a inserção de pessoas com deficiências em sala de aula. No tocante à metodologia, recorremos às pesquisas bibliográficas e documentais, atravessadas pela abordagem qualitativa, visando deslindar fenômenos sociais atinentes. À rigor, circunscrevemos que os educadores devem combater preconceitos, estigmas e rotulações calcadas nas descrenças, no pessimismo e no capacitismo, apontando a inclusão como uma ferramenta estratégica e oportuna para os educadores e a comunidade escolar possa reconhecer a pessoa com deficiência como sujeito de direitos, cabendo aos professores exigir condições dignas de trabalho, salários e planos de carreiras mais condizentes com suas responsabilidades dentro das instituições oficiais de ensino-aprendizagem. Sumariamente, detectamos que apesar das tímidas iniciativas em algumas comunidades escolares de alguns municípios e estados do Brasil, é vital a construção urgente desta nova escola inclusiva, libertando toda a sociedade desta velha escola sectária, intolerante às diferenças, excludente e que só alimenta a roda viva de excluídos em todos os sentidos e níveis, juntamente com a aproximação ou o equilíbrio do que se profere na legislação educacional, pautada pelas políticas de inclusão.
Trends and risk factors in musculoskeletal disorders among stomatologists
Authors: Fernández Queija Yivelin , Campello Trujillo Learsys Ernesto , Rodríguez Yane Ana , Zayas Suárez Adaisbel , Ramírez Fritze Riger 
Published: April 2024

Introduction: stomatologists face musculoskeletal disorders due to inadequate postures and unfavorable ergonomic conditions at work, with an increase in risk with work experience, underscoring the importance of prevention. Methods: a cross-sectional observational study was conducted on musculoskeletal disorders in stomatologists in Guanabacoa, Havana, with 48 participants. Data were collected by means of surveys and postural observations, respecting ethical principles and obtaining informed consent. Results and discussion: this study shows that stomatologists between 35 and 44 years old are the most affected by musculoskeletal disorders, with the majority having between 11 and 20 years of work experience. Women present more disorders than men, although there is no statistical association between gender and disorders. It is highlighted that inadequate postures during work, especially in the cervical area and shoulders, may contribute to these problems. In addition, technical problems in dental units may also play a role. It is essential to consider working postures and ergonomic conditions to prevent these disorders. Conclusion: a high frequency of risk factors was observed, being for the female sex and the EGI specialty the most common. A preference was found for seated work and the use of inadequate postures, which resulted in a greater number of affections in the cervical region and shoulders. In addition, a close relationship was established between inadequate postures and non-ergonomic dental units with the occurrence of musculoskeletal disorders
A CASE REPORT: RECONSTRUCTION OF THE CALCANEAL REGION DEFECT USING THE MEDIAL PLANTAR FREE FLAP
Authors: Vu Huu Trung , Le Anh Tu , Nguyen Ngoc Thach , Tran Hoang Dat , Nguyen Huu Dat 
Published: April 2024

Soft tissue defects in the calcaneal region represent a reconstructive challenge because of their complexity and the lack of local flaps. We report a clinical case of using the medial plantar free flap to cover of this area. The advantages of the flaps will be discussed.
Analysis of the Quality of Subdistrict Integrated Administration Services (PATEN) at the Samarinda Ilir Sub-District Office in Samarinda City
Authors: Asnar Asnar 
Published: April 2024

This study was conducted with the aim of analyzing the Quality of Subdistrict Integrated Administration Service Delivery (PATEN) at the Samarinda Ilir District Office, Samarinda City, along with its supporting and inhibiting factors. Research methods with a qualitative approach, sampling as informants with purposive sampling techniques and accidental sampling techniques. Data collection techniques, with in-depth interviews, participatory observations, and documentation studies. Data analysis techniques with Miles and Huberman's interactive model data analysis techniques. The results showed that the overall quality of patent implementation at the Samarinda Ilir District Office, Samarinda City, was good, which was proven through measuring the five dimensions of public service quality analysis, namely reliability, responsiveness, certainty, empathy, and tangibility. The supporting factors, namely very adequate office service facilities, such as the use of computer devices and printers that are adequate in number, queuing machines and special counters that ensure order in the queue during the service process, air conditioning that provides comfort, both for employees and the community served, television as a means of entertainment for the community as well as to eliminate community saturation in the service process, as well as comfortable seating for the community during the service process, while the inhibiting factor is still not yet otpimal socialization to the community by the village and the Head of RT that several licensing services, such as Building Permits (IMB), State Land Opening Permits (IMTN), and Micro Business Permits (IUM) can be managed in the sub-district with criteria and conditions that have been determined in accordance with the provisions laws and regulations.
Tari Telek Nyandar Ati Sebuah Inspirasi dari Tapel Ni Swarni
Authors: Rakasiwi I Dewa Ayu Galuh Intan , Suandewi Gusti Ayu Ketut , Widnyana Kompyang Gede 
Published: April 2024

Tari Telek merupakan tarian yang menggunakan tapel, berkarakter halus, indentik dengan menggunakan properti kipas. Tari Telek Nyandar Ati merupakan sebuah karya yang terlahir dari riset. Tari ini terinspirasi dari sebuah tapelyang ada di Desa Adat Intaran, wilayah Sanur Kauh yaitu TapelNi Swarni. Tari ini memiliki kekhasan sendiri mulai dari awal mula terciptanya, bentuk, dan fungsi Tari Telek Nyandar Ati.
Penelitian ini menggunakan metode kualitatif dengan pendekatan esetetika dan sosio historis. Data yang diperoleh melalui observasi, wawancara terstruktur dan wawancara tak terstruktur, dan secara tidak langsung melalui studi kepustakaan, serta dokumentasi. Pada kesempatan ini peneliti mengambil kebijakan MBKM program Riset atau Penelitian dengan objek penelitian Tari Telek Nyandar Ati Sebuah Inspirasi dari Tapel Ni Swarni.
Tari Telek Nyandar Ati merupakan sebuah karya yang terinspirasi dari tapel Ni Swarni. Tapel Ni Swarni merupakan hasil imajinasi Ida Pedande Made Sideman terhadap wanita yang sangat cantik dan yang sangat beliau cintai yaitu Ni Swarni yang merupakan istri beliau. Tari Telek Nyandar Ati merupakan tari kelompok yang ditarikan oleh enam orang penari yang terdiri dari tiga orang penari telek dan tiga orang penari laki-laki sebagai pengabih. Tari Telek Nyandar Ati adalah sebuah karya yang berawal dari sebuah riset, memiliki struktur pertunjukan sebagai berikut: metaki-taki, pamahbah, pengawak, pengecet, dan ngewaliang pragina. Tari ini awalnya difungsikan sebagai pertunjukan idealis, kemudian seiring dengan perjalanannya difungsikan sebagai tari pengiring saat seuhunan di Pura Dalem Pacekan Penestanan napak pertiwi.

Kata Kunci: Ni Swarni, Nyandar Ati, telek
Proses Kreatif Tari Eling Bhumi Di Sanggar Pancer Langit Desa Kapal Kabupaten Badung
Authors: Andayani Ni Komang Ari , Suteja I Kt. , Widnyana Kompiang Gede 
Published: April 2024

Tujuan penciptaan berjudul Proses kreatif tari Eling Bhumi di Sanggar Pancer Langit adalah untuk kreatifitas karya tari kontemporer. Sanggar Pancer Langiit merupakan salah satu sanggar yang terletak di Desa Kapal Kabupaten Badung, yang juga memiliki makna sebagai pusat atau sumber dari segala kekuatan dan langit/lelangit yang berarti leluhur simbol pelindung yang abadi. Metode yang digunakan dalam penelitian ini yaitu menggunakan metode kualitatif, karena data yang diperoleh berupa wawancara yang kemudian hasil dari wawancara tersebut dideskripsikan melalui tulisan dengan kalimat yang detail serta menggunakan teknik dokumentasi dan teknik studi pustaka. Tari kontemporer Eling Bhumi menggambarkan atau menanggapi fenomena pandemi Covid-19 yang sedang melanda dunia saat ini, fenomena ini juga membuat segala sektor kehidupan menjadi terdampak. Konsep garap Eling Bhumi ini mencoba untuk mengolah secara kreatif beberapa unsur gerak tubuh dalam tari dan musik serta mengolahnya dengan memadukan aspek visual permainan properti lontar sehingga menjadi karya seni yang utuh.

Kata Kunci: Proses Kreatif, Tari Eling Bhumi, Pancer Langiit
Prospectiva de la Industria en Chiapas / México y su Impacto para la Disminución de la Desigualdad Socioeconómica
Authors: Sanchez Moreno Yurley , Flórez Montañez Ludy Amira , Vázquez Constantino Enrique Alberto 
Published: April 2024

Este artículo tiene cómo propósito analizar la prospectiva de la industria en el Estado de Chiapas / México a través de medición y caracterización de empresas con base tecnológica tomadas como casos de estudio, dicha investigación se da a través de un enfoque holístico y cualitativo, usando la técnica de la observación directa para la recolección de información, con el fin de que dicha información no sea alterada, en este sentido, se da uso de un modelo descriptivo el cual busca especificar propiedades, características y rasgos importantes de cualquier fenómeno que se analice, en este caso de las empresas objeto de estudio, y de esta manera se llega a la identificación de una serie de estrategias clave para la disminución de la desigualdad social en el Estado de Chiapas, clasificadas en la mejora de la productividad, fomento del empleo formal y generar un impulso a las actividades económicas con mayor complejidad, base tecnológica y con una ventaja comparativa revelada.
PENINGKATAN LAYANAN KEAGAMAAN DI WILAYAH PESISIR KABUPATEN LINGGA MELALUI PROGRAM LAYANAN TERAPUNG KEAGAMAAN
Authors: Budi Setia Budi 
Published: April 2024

Artikel ini membahas mengenai peningkatan layanan keagamaan di wilayah pesisir Kabupaten Lingga melalui program layanan terapung keagamaan. Program ini merupakan sebuah inovasi pelayanan dari Kantor Kementerian Agama Kabupaten Lingga dalam memberikan pelayanan keagamaan pada masyarakat pesisir di Kabupaten Lingga yang kurang ketersedian layanan keagamaan. Program layanan terapung keagaman ini sebagai bentuk responsifitas dari Kantor Kementerian Agama Kabupaten Lingga terhadap program Zona Integritas Menuju Wilayah Bebas dari Korupsi dan Wilayah Birokrasi Bersih dan Melayani Kementerian Agama RI. Dimana untuk meningkatkan layanan kegamaan pada Masyarakat pesisir di Kabupaten Lingga, Kantor Kementerian Agama Kabupaten Lingga mempunyai kebijakan seperti Penyediaan Sarana Transportasi laut berupa kapal kayu, pengajuan tambahan anggaran ke eselon satu Kementerian Agama dan pelaksanaan program layana terapung keagamaan yang dinamakan Lantera. Dengan adanya program layanan terapung keagamaan terbentuk suatu interaksi secara langsung antara masyarakat pesisir yang sangat membutuhkan layanan keagamaan dengan petugas yang akan menyampaikan layanan keagaman. Sehingga mempermudah dan menghemat biaya bagi masyarakat pesisir.
Neurolanguage coaching as the basis of forming students’ readiness for professional foreign-language communication
Authors: Батенина И.К. 
Published: April 2024

данная работа затрагивает весьма актуальную проблему поиска наиболее эффективного подхода к формированию готовности обучающихся высших учебных заведений к профессиональной коммуникации на иностранном языке. Автор статьи рассматривает возможность внедрения и реализации отдельных элементов инновационной концепции Neurolanguage Coaching® в рамках практических занятий по дисциплинам «Иностранный язык» и «Иностранный язык профессионального общения». В статье описаны ключевые особенности данной концепции нейроязыкового коучинга, а также специфика проведения соответствующего обучения, осуществляемого в ФГБОУ ВО «РЭУ им. Г.В. Плеханова». Автор утверждает, что обучение на основе реализации принципов работы головного мозга имеет ряд неоспоримых преимуществ, обусловивших цель настоящей работы – обоснование эффективности формирования готовности молодых специалистов к профессиональной коммуникации на иностранном языке. В статье изложены результаты проведения опытного обучения студентов 1-3 курсов «РЭУ им. Г.В. Плеханова». Автор выработал ряд педагогических условий, соблюдение которых призвано повысить результативность обучения студентов неязыкового вуза иностранному языку. Практическая значимость настоящего исследования обусловлена возможностью применения разработанных рекомендаций для обеспечения процесса соответствующей иноязычной подготовки будущих специалистов.
this paper touches upon quite a topical problem of finding the most effective approach to the formation of readiness of students of higher educational institutions for professional communication in a foreign language. The author of the article considers the possibility of introduction and implementation of separate elements of the innovative concept of Neurolanguage Coaching® in the framework of practical classes on disciplines "Foreign Language" and "Foreign language of professional communication". The article describes the key features of this Neurolanguage Coaching concept, as well as the specifics of the relevant training, carried out at the Plekhanov Russian University of Economics. The author states that training based on the implementation of the principles of brain work has a number of undeniable advantages, which determined the purpose of this work that is to justify the effectiveness of formation of young specialists' readiness for professional foreign language communication. The article presents the results of experimential teaching students of 1-3 courses studying at Plekhanov Russian University of Economics. The author has worked out a number of pedagogical conditions, the observance of which is aimed at increasing the effectiveness of foreign language teaching to students at a non-linguistic university. The practical significance of the present study is proved by the possibility of applying the developed recommendations to ensure the process of appropriate foreign language training of future specialists.
The methodology of the study of the career growth of a teacher at a modern university
Authors: Алексеева П.М. 
Published: April 2024

проблема профессионального роста преподавателя вуза в различные исторические периоды занимала и занимает значительное место в педагогических исследованиях. Это, в первую очередь, связано с той ролью, которую выполняет вузовское образование в процессах трансформации общества, экономики, создании условий для развития человеческого потенциала [1]. Карьерный рост преподавателя современного вуза с точки зрения исследования представляет собой сложный объект, что требует определения соответствующих методологических позиций. Иными словами, для исследования данного феномена необходим набор выверенных методологических инструментов. Такими инструментами выступают известные уже в науке методы научного исследования, применимые в гуманитарных науках вообще и в области профессиональной педагогики, в частности. Подобранные и применяемые в определенной последовательности и соотношении, методы научных исследований позволяют выходить в отношении исследуемого объекта на понимание тех или иных закономерностей, устанавливать причинно-следственные связи, вскрывать и интерпретировать сущностные явления. Данная статья посвящена анализу методологии исследования карьерного роста преподавателя, междисциплинарности этого исследования.
the problem of professional growth of a university teacher in various historical periods has occupied and occupies a significant place in pedagogical research. This is primarily due to the role that university education plays in the transformation of society, the economy, and the creation of conditions for the development of human potential [1]. The career growth of a teacher of a modern university from the point of view of research is a complex object, which requires the definition of appropriate methodological positions. In other words, a set of verified methodological tools is needed to study this phenomenon. Such tools are the methods of scientific research already known in science, applicable in the humanities in general and in the field of professional pedagogy, in particular. Selected and applied in a certain sequence and ratio, the methods of scientific research allow us to understand certain patterns in relation to the object under study, establish cause-and-effect relationships, reveal and interpret essential phenomena. This article is devoted to the analysis of the methodology of the research of the career growth of a teacher, the interdisciplinarity of this research.