bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital twin model of a large scale hot molten metal ladle pouring system
Authors: Popov Ivan , Griffiths Christian A. 
Published: May 2024

AbstractIn steel-making processes, large quantities (frequently exceeding 300 t) of liquid metal are transferred between vessels. In Basic Oxygen Steel (BOS) making process, metal is poured from Hot Metal (HM) ladles, utilising overhead gantry cranes, into furnaces for further processing. Due to the large quantities of liquid metal poured, this operation poses significant safety concerns associated with metal spillage and releases of heat emissions. This can further lead to damage being caused to surrounding infrastructure. Pouring automation can reduce the likelihood of metal spillage, optimising ladle movement for reduction in heat emission releases. Given the hazardous nature of this operation, robust testing and evaluation of automated crane pouring movements is required prior to their application. A digital twin (DT) model of an overhead gantry crane/HM ladle system is presented here, intended to provide a safe testing environment for controlled pouring movement and serve as a testbed for control system design studies. Accurate crane movement is achieved using multi-body dynamics, solving for non-linearities present due to rigid joint frictional components. The flow rate of HM is estimated through the application of a dynamic model, allowing the modelling of system dynamics due to differences in HM pouring weights. The devised DT model is evaluated by simulating real crane movement and making a comparison on the resultant changing HM weight inside the ladle. The devised DT removes the need for construction of a physical model or performing tests directly on the HM pouring system.
A Variational Perspective on Auxetic Metamaterials of Checkerboard-Type
Authors: Düll Wolf-Patrick , Engl Dominik , Kreisbeck Carolin 
Published: May 2024

AbstractThe main result of this work is a homogenization theorem via variational convergence for elastic materials with stiff checkerboard-type heterogeneities under the assumptions of physical growth and non-self-interpenetration. While the obtained energy estimates are rather standard, determining the effective deformation behavior, or in other words, characterizing the weak Sobolev limits of deformation maps whose gradients are locally close to rotations on the stiff components, is the challenging part. To this end, we establish an asymptotic rigidity result, showing that, under suitable scaling assumptions, the attainable macroscopic deformations are affine conformal contractions. This identifies the composite as a mechanical metamaterial with a negative Poisson’s ratio. Our proof strategy is to tackle first an idealized model with full rigidity on the stiff tiles to acquire insight into the mechanics of the model and then transfer the findings and methodology to the model with diverging elastic constants. The latter requires, in particular, a new quantitative geometric rigidity estimate for non-connected squares touching each other at their vertices and a tailored Poincaré type inequality for checkerboard structures.
The relationship between the force applied and perceived by the surgeon during ureteral access sheath placement: ex-vivo experimental model
Authors: Tefik Tzevat , Ergül Rifat Burak , Osther Palle , Giusti Guido , Preminger Glenn M. , Straub Michael , Rassweiler Jens Jochen , Montanari Emanuele , Brehmer Marianne , Seitz Christian , Grasso Michael , Pearle Margaret , Proietti Silvia , Cloutier Jonathan , Gunver MGuven , Nane Ismet , Ozcan Faruk , Traxer Olivier 
Published: May 2024

Abstract
Purpose
To define a peak force of insertion (PFOI) threshold for ureteral damage during ureteral access sheath (UAS) placement on an experimental ureteral orifice model.

Methods
A specially designed water tank using 2 laparoscopic 5 mm ports and 2 different size (10 Fr and 8 Fr) sealing cap adaptors (SCA) as ureteral orifices was used to perform the test. A 10–12 Fr UAS was fixed to a load cell and the force of insertion (FOI) was continuously recorded with a digital force gauge.13 experts in the field of endourology who participated performed 3 UAS insertions. The FOI was recorded initially with 10 Fr followed by 8 Fr SCA. On the final insertion, the orifice was obstructed, leaving a 5 cm length to insert the UAS. The experts were asked to “Stop at the point they anticipate ureteral damage, and they would not proceed in real life”.

Results
Using 10 Fr SCA the PFOI was 2.12 ± 0.58 Newton (N) (range:1.48–3.48) while 8 Fr SCA showed a PFOI 5.76 ± 0.96 N (range:4.05–7.35). Six of the experts, said they would stop proceeding when they reached above 5.1 N. Three experts had PFOI < 5.1 N and the other 4 stated they would go with PFOIs of 5.88, 6.16, 6.69 and 7.35 N when using SCA of 8 Fr.The highest load they would stop proceeding had a PFOI of 6.09 ± 1.87 N (range: 2.53–10.74).

Conclusion
The PFOI threshold for ureteral damage inserting UAS of the experts is variable. Although FOI is a subjective perception, experience suggests that ureteral injury may occur at an average of 6.05 N perceived by surgeons’ tactile feedback. In-vivo measurement of UAS PFOI may confirm a threshold.
The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg
Authors: Zhu Fuping , Liu Hui , Cao Yinsheng , Dai Bing , Wu Hang , Li Wuping 
Published: May 2024

Abstract
Background
Postmenopausal osteoporosis (PMO) is a chronic condition characterized by decreased bone strength. This study aims to investigate the effects and mechanisms of the combination of Butyricicoccus pullicaecorum (Bp) and 3-hydroxyanthranilic acid (3-HAA) on PMO.

Methods
The effects of Bp and 3-HAA on PMO were evaluated in ovariectomized (OVX) rats by assessing stereological parameters, femur microstructure, and autophagy levels. The T helper (Th) 17/Regulatory T (Treg) cells of rats were detected using flow cytometric analysis. Furthermore, the impact of Bp and 3-HAA on the gut microbiota of rats was assessed using 16S rRNA gene sequencing. The correlation between the gut microbiota of rats and Th17/Treg immune factors, as well as femoral stereo parameters, was separately assessed using Spearman rank correlation analysis.

Results
Bp and 3-HAA treatments protected OVX rats by promoting osteogenesis and inhibiting autophagy. Compared to the Sham group, OVX rats showed an increase in Th17 cells and a decrease in Treg cells. Bp and 3-HAA reversed these changes. Enterorhabdus and Pseudomonas were significantly enriched in OVX rats. Bp and 3-HAA regulated the gut microbiota of OVX rats, enriching pathways related to nutrient metabolism and immune function. There was a correlation between the gut microbiota and the Th17/Treg, as well as femoral stereo parameters. The concurrent administration of Bp and 3-HAA medication facilitated the enrichment of gut microbiota associated with the improvement of PMO.

Conclusion
The combination therapy of Bp and 3-HAA can prevent PMO by modulating the gut microbiota and restoring Th17/Treg immune homeostasis.
Language profile of children with cochlear implants: comparative study about the effect of age of cochlear implantation and the duration of rehabilitation
Authors: Farag Heba Mahmoud , Osman Dalia Mostafa , Safwat Rasha Farouk 
Published: May 2024

Abstract
Purpose
The analysis of different language domains and exploration of variables that affect the outcomes of cochlear implantation would help to document the efficacy of cochlear implantation and intervention programs. The aim of this work was to examine the language profile of children with Cochlear Implants (CI) and to assess the effect of age at the time of cochlear implantation and the impact of duration of rehabilitation on the development of linguistic abilities for cochlear implanted children.

Methods
The study was conducted on 46 Arabic speaking children using unilateral CI who are receiving regular post-cochlear auditory and language rehabilitation in the phoniatrics unit, Kasr Alaini hospital. A Proficient Preschooler Language Evaluation (APPEL TOOL) was applied for the assessment of different language domains.

Results
Children who received post implant rehabilitation for ≥ 2 years showed significant improvement in all subtests' scores of APPEL tool than children who received same rehabilitation for ≤ 1 year. There was no significant difference of language scores between children who have received CI before age of 3 years and those who have been implanted after age of 3 years.

Conclusion
This study showed that the language profile of CI children was beneficially affected by the longer duration of therapy post implantation.
From feulgen to modern methods: marking a century of DNA imaging advances
Authors: Lakadamyali Melike 
Published: May 2024

AbstractThe mystery of how human DNA is compactly packaged into a nucleus—a space a hundred thousand times smaller—while still allowing for the regulation of gene function, has long been one of the greatest enigmas in cell biology. This puzzle is gradually being solved, thanks in part to the advent of new technologies. Among these, innovative genome-labeling techniques combined with high-resolution imaging methods have been pivotal. These methods facilitate the visualization of DNA within intact nuclei and have significantly contributed to our current understanding of genome organization. This review will explore various labeling and imaging approaches that are revolutionizing our understanding of the three-dimensional organization of the genome, shedding light on the relationship between its structure and function.
Examining the relationship between genetic polymorphisms (BDKRB2, GNB3, HIF1A, MCT1, NOS3) and endurance athlete status
Authors: İpekoğlu Gökhan , Apaydın Necdet , Çetin Tuğba , Eren Ahsen Nur , Topçu Pelinsu , Yücelsoy Büşra , Civelek Güngör , Sakar Mert 
Published: May 2024

Abstract
Purpose
Genetic factors are important in terms of athletic performance. Recent studies to determine the relationship between the genes that lead to physiological responses have attracted attention. In this respect, this meta-analysis study was designed to examine the relationship between genetic polymorphism (BDKRB2 rs5810761, GNB3 rs5443, HIF1A rs11549565, MCT1 rs1049434, NOS3 rs2070744) and endurance athlete’s status.

Methods
The search included studies published from 2009 to 2022. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned. Only case-control studies were included in the meta-analysis. To determine the relevant studies, Pubmed, Web of Science databases were systematically scanned, and a total of 31 studies met the criteria for inclusion in the meta-analysis. Relevant data from the included studies were collected and analyzed using a random effects or fixed effects model. The effect size was calculated as the odds ratio or a risk ratio the corresponding 95% confidence intervals.

Results
According to the results of the analysis, BDKRB2 rs5810761 + 9 allele, and NOS3 rs2070744 T allele were significantly more prevalent in endurance athletes (p < 0.05). Genotype distributions of BDKRB2 rs5810761, MCT1 rs1049434, and NOS3 rs2070744 showed significant differences in the dominant model (p < 0.05). However, no significant association was found between endurance athlete status and GNB3 rs5443 and HIF1A rs11549465 polymorphisms.

Conclusion
These results show that some gene polymorphisms play an important role in endurance athlete status and suggest that having a specific genetic basis may also confer a physiological advantage for performance.
Emotional problems across development: examining measurement invariance across childhood, adolescence and early adulthood
Authors: Riglin Lucy , Dennison Charlotte , Martin Joanna , Tseliou Foteini , Armitage Jessica M , Shakeshaft Amy , Heron Jon , Tilling Kate , Thapar Anita , Collishaw Stephan 
Published: May 2024

AbstractEmotional problems (anxiety, depression) are prevalent in children, adolescents and young adults with varying ages at onset. Studying developmental changes in emotional problems requires repeated assessments using the same or equivalent measures. The parent-rated Strengths and Difficulties Questionnaire is commonly used to assess emotional problems in childhood and adolescence, but there is limited research about whether it captures a similar construct across these developmental periods. Our study addressed this by investigating measurement invariance in the scales’ emotional problems subscale (SDQ-EP) across childhood, adolescence and early adulthood. Data from two UK population cohorts were utilised: the Millennium Cohort Study (ages 3–17 years) and the Avon Longitudinal Study of Parents and Children (4–25 years). In both samples we observed weak (metric) measurement invariance by age, suggesting that the parent-rated SDQ-EP items contribute to the underlying construct of emotional problems similarly across age. This supports the validity of using the subscale to rank participants on their levels of emotional problems in childhood, adolescence and early adulthood. However strong (scalar) measurement invariance was not observed, suggesting that the same score may correspond to different levels of emotional problems across developmental periods. Comparisons of mean parent-rated SDQ-EP scores across age may therefore not be valid.
Using attentional guidance methods in virtual reality laboratories reduces students’ cognitive load and improves their academic performance
Authors: Wen Pingping , Lu Fei , Mohamad Ali Ahmad Zamzuri 
Published: May 2024

AbstractLearning in virtual reality laboratories (VR labs) has become an important method in experimental teaching but can increase individuals’ cognitive load compared with traditional laboratories. This study analysed the effect of introducing an attentional guidance mechanism into a VR lab on students’ cognitive load and academic performance. We designed and developed two VR labs, one with and one without this attentional guidance stimulus (a 3D yellow arrow). A quasi-experimental design was adopted, and the data obtained were analysed using one-way ANOVA and linear regression. The experiment was conducted with 80 students majoring in digital media art at two universities. The results indicated that the students in the VR lab with the attentional guidance mechanism included exhibited lower cognitive load and higher academic performance than the control group. The regression analyses revealed that cognitive load negatively predicted learning outcomes; that is, academic performance improved as cognitive load decreased. In conclusion, as VR labs are increasingly used in education, supplementing them with attentional guidance stimuli can improve students’ academic performance by reducing their cognitive load.
Greening up the fight against emerging contaminants: algae-based nanoparticles for water remediation
Authors: Premarathna K. S. D. , Lau Sie Yon , Chiong Tung , Show Pau-Loke , Vithanage Meththika , Lam Man Kee 
Published: May 2024

AbstractNanoparticles are commonly used for different purposes, including as photocatalysts, biosensors, antibacterial, antifungal, and anticancer agents. Recently, the synthesis of nanoparticles via biological techniques has become popular due to cost efficiency, sustainability, and the least secondary pollutants generation. Plants, algae, and microorganisms are primarily used to synthesize bio-nanoparticles. Algae-based nanoparticles have gained more attention due to their catalytic activity against emerging organic contaminants such as dyes, phenols, and organosulfur compounds. Nevertheless, a systemic evaluation of the potential of algae-based nanoparticles in environmental remediation is yet to be conducted. This paper reviews recent progress in the biosynthesis of algae-based nanoparticles and the potential use of algae-based nanoparticles in environmental remediation. Furthermore, the review examines the factors that affect the properties and behaviors of algae-based nanoparticles. Additionally, the review briefly discusses other medical and industrial applications as well as advantages over physically and chemically synthesized nanoparticles. Challenges associated with the production process and usage of algae-based nanoparticles are also discussed, including the difficulty of predicting the properties of nanoparticles and adapting to large-scale processes. Overall, algae-based nanoparticles have several advantages, including their high stability and surface activity due to the presence of surface functional groups from algae species used for the synthesis of algae-based nanoparticles. However, further research is required to address the knowledge gaps and potential key research areas.
Graphical Abstract
How to quantify the regional effects of ocean temperature rise due to climate change: implications of Octopus maya ecophysiology on food security of the Yucatan shelf artisanal fishermen
Authors: Escamilla-Aké Ángel , Angeles-Gonzalez Luis Enrique , Kurczyn Alejandro , Caamal-Monsreal Claudia , Rosas Carlos 
Published: May 2024

AbstractThe vital survival, maturation, and reproduction rates of Octopus maya were formulated according to the thermal preferences in each stage (juvenile and adult) and the bottom temperature of the Yucatan shelf projected from different shared socioeconomic pathways (SSPs): SSP1-5, to describe the species population growth in shallow waters. The dispersion of each individual in the population and the spread of the offshore population were incorporated with an integrodifference equation. For each SSP, the food security of the artisanal fishermen in the Western, Central, and Eastern Yucatan shelf region was analyzed based on the proposed availability, access, and utilization indices of Octopus maya as food. The analysis was complemented with an average monthly protein and income poverty indicators that this species’ shallow water fishery would have the capacity to supply by the year 2100. Although the proportion of the legally O. maya catchable population may be favored with the gradual increase in temperature in the coming years, this increase may not translate into greater food security for the artisanal fishermen who catch this species in shallow waters. Moreover, this fishery alone may not have the capacity to supply the average annual intake of 10.6 kg of protein per person recommended and maintain fishermen and their families above the income poverty line by 2100.
Effects of equatorial plasma bubble-induced ionospheric gradients on GNSS PPP-RTK
Authors: Tang Long , Zhang Fenkai , Li Pan , Deng Yuanfan , Chen Wu 
Published: May 2024

AbstractEquatorial plasma bubble (EPB) exerts a severe threat to global navigation satellite system (GNSS) technique. It not only can lead to ionospheric scintillation, but also can create strong plasma gradients in ionosphere. In this study, we investigate the effects of EPB-induced ionospheric gradients on GNSS precise point positioning with real-time kinematic (PPP-RTK) technique for the first time. A common medium-scale EPB event occurred in ionosphere over the southern U.S. on May 28, 2017 is served as a case. The results show, during the period of the EPB event, the interpolated ionospheric residuals are very large with maximum 7.5 TECU without EPB correction while the counterparts are generally below 1 TECU with EPB correction. As for the 3D positions, EPB-induced ionospheric gradients mainly affect the initialization or re-initialization process of PPP-RTK solutions, which significantly increase the estimated errors and lengthen the convergence times. This study can help the GNSS community understand EPB’s impacts on GNSS PPP-RTK more deeply and provide support for its mitigation in the next work.
AI, Law and beyond. A transdisciplinary ecosystem for the future of AI & Law
Authors: Bex Floris J. 
Published: May 2024

AbstractWe live in exciting times for AI and Law: technical developments are moving at a breakneck pace, and at the same time, the call for more robust AI governance and regulation grows stronger. How should we as an AI & Law community navigate these dramatic developments and claims? In this Presidential Address, I present my ideas for a way forward: researching, developing and evaluating real AI systems for the legal field with researchers from AI, Law and beyond. I will demonstrate how we at the Netherlands National Police Lab AI are developing responsible AI by combining insights from different disciplines, and how this connects to the future of our field.
Amyloid β accelerates age-related proteome-wide protein insolubility
Authors: Anderton Edward , Chamoli Manish , Bhaumik Dipa , King Christina D. , Xie Xueshu , Foulger Anna , Andersen Julie K. , Schilling Birgit , Lithgow Gordon J. 
Published: May 2024

AbstractLoss of proteostasis is a highly conserved feature of aging across model organisms and results in the accumulation of insoluble protein aggregates. Protein insolubility is also a unifying feature of major age-related neurodegenerative diseases, including Alzheimer's Disease (AD), in which hundreds of insoluble proteins associate with aggregated amyloid beta (Aβ) in senile plaques. Despite the connection between aging and AD risk, therapeutic approaches to date have overlooked aging-driven generalized protein insolubility as a contributing factor. However, proteins that become insoluble during aging in model organisms are capable of accelerating Aβ aggregation in vitro and lifespan in vivo. Here, using an unbiased proteomics approach, we questioned the relationship between Aβ and age-related protein insolubility. Specifically, we uncovered that Aβ expression drives proteome-wide protein insolubility in C. elegans, even in young animals, and this insoluble proteome is highly similar to the insoluble proteome driven by normal aging, this vulnerable sub-proteome we term the core insoluble proteome (CIP). We show that the CIP is enriched with proteins that modify Aβ toxicity in vivo, suggesting the possibility of a vicious feedforward cycle in the context of AD. Importantly, using human genome-wide association studies (GWAS), we show that the CIP is replete with biological processes implicated not only in neurodegenerative diseases but also across a broad array of chronic, age-related diseases (CARDs). This provides suggestive evidence that age-related loss of proteostasis could play a role in general CARD risk. Finally, we show that the geroprotective, gut-derived metabolite, Urolithin A, relieves Aβ toxicity, supporting its use in clinical trials for dementia and age-related diseases.