bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attachment style and its relationship to working alliance in the supervision of British clinical psychology trainees
Authors: Dickson Joanne M. , Moberly Nicholas J. , Marshall Yehuda , Reilly James 
Published: July 2010

AbstractAlthough the supervisory relationship is thought to be critical in training clinical psychologists, little is known about factors affecting the supervisory alliance. We conducted an Internet survey of British clinical doctoral trainees (N = 259) in which participants rated their supervisory working alliance, parental style during childhood, pathological adult attachment behaviours and attachment style for themselves and their supervisors. Trainees' ratings of the working alliance were associated with perceptions of supervisors' attachment style, but not with perceptions of trainees' own attachment styles. Path analysis supported a causal chain linking parental indifference, compulsive self‐reliance, insecure supervisor attachment style and lower ratings of the working alliance. Our results broadly replicate data from a US sample and suggest that attachment theory is helpful in understanding clinical supervisory processes. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• The attachment theory is helpful in understanding clinical supervisory processes.• Perceptions of supervisors' attachment style are associated with quality of the supervisory working alliance.• Compulsive self‐reliance in trainees may present particular difficulties for the supervisory working alliance.
Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes
Authors: Mato Susana , Victoria Sánchez‐Gómez María , Matute Carlos 
Published: July 2010

AbstractHeavy marijuana use has been linked to white matter histological alterations. However, the impact of cannabis constituents on oligodendroglial pathophysiology remains poorly understood. Here, we investigated thein vitroeffects of cannabidiol, the main nonpsychoactive marijuana component, on oligodendrocytes. Exposure to cannabidiol induced an intracellular Ca2+rise in optic nerve oligodendrocytes that was not primarily mediated by entry from the extracellular space, nor by interactions with ryanodine or IP3receptors. Application of the mitochondrial protonophore carbonylcyanide‐p‐trifluoromethoxyphenylhydrazone (FCCP; 1 μM) completely prevented subsequent cannabidiol‐induced Ca2+responses. Conversely, the increase in cytosolic Ca2+levels elicited by FCCP was reduced after previous exposure to cannabidiol, further suggesting that the mitochondria acts as the source of cannabidiol‐evoked Ca2+rise in oligodendrocytes. n addition, brief exposure to cannabidiol (100 nM–10 μM) led to a concentration‐dependent decrease of oligodendroglial viability that was not prevented by antagonists of CB1, CB2, vanilloid, A2Aor PPARγ receptors, but was instead reduced in the absence of extracellular Ca2+. The oligodendrotoxic effect of cannabidiol was partially blocked by inhibitors of caspase‐3, ‐8 and ‐9, PARP‐1 and calpains, suggesting the activation of caspase‐dependent and ‐independent death pathways. Cannabidiol also elicited a concentration‐dependent alteration of mitochondrial membrane potential, and an increase in reactive oxygen species (ROS) that was reduced in the absence of extracellular Ca2+. Finally, cannabidiol‐induced cytotoxicity was partially prevented by the ROS scavenger trolox. Together, these results suggest that cannabidiol causes intracellular Ca2+dysregulation which can lead to oligodendrocytes demise. © 2010 Wiley‐Liss, Inc.
Differential expression of SOCS1 in macrophages in relapsing‐remitting and chronic EAE and its role in disease severity
Authors: Berard Jennifer L. , Kerr Bradley J. , Johnson Howard M. , David Samuel 
Published: July 2010

AbstractExperimental autoimmune encephalomyelitis (EAE) is a T cell‐mediated neuroinflammatory disease that is often used as a model of multiple sclerosis. EAE can follow either relapsing‐remitting (RR) or chronic (CH) courses, yet the factors responsible for differentially inducing these forms of disease remain largely unknown. Proinflammatory cytokines play an important role in EAE, and signaling by these cytokines can be negatively regulated by the suppressor of cytokine signaling 1 protein (SOCS1). We assessed if differential expression of SOCS1 could contribute to the clinical course of RR and CH forms of EAE induced in the same mouse strain (C57BL/6) using the same myelin antigen (myelin oligodendrocyte glycoprotein). We show that SOCS1 mRNA levels are significantly elevated in the spinal cord in early stages of both RR‐ and CH‐EAE. SOCS1 protein is highly expressed in immune cells in EAE lesions in the spinal cord, with expression predominantly localized within macrophages. Importantly, the number of Mac‐1+ macrophages expressing SOCS1 at the peak stage of RR disease is three‐fold greater than in CH‐EAE. Furthermore, the macrophage effector molecule iNOS, whose expression is regulated by SOCS1, is significantly reduced at the peak of RR‐ versus CH‐EAE. Finally, the administration of a SOCS1‐mimetic peptide reduces disease severity in the CH‐EAE model. Thus, the differential expression of SOCS1 may contribute to the development of RR and CH forms of EAE. © 2010 Wiley‐Liss, Inc.
Free flap reconstruction for osteoradionecrosis of the jaws—Outcomes and predictive factors for success
Authors: Cannady Steven B. , Dean Nichole , Kroeker Andrew , Albert Thomas A. , Rosenthal Eben L. , Wax Mark K. 
Published: July 2010

AbstractBackground.The purpose of this study was to determine factors to predict the success of free flap surgery in the treatment of osteoradionecrosis (ORN).Methods.Univariate analysis of overall and flap complications was performed. The effect of time to ORN, and the time interval between ORN to reconstruction was evaluated.Results.Fifty‐five flaps on 53 patients for ORN were done with a 90% resolution rate. Univariate parameter analysis was significant for infield mandibulotomy. An increased time interval from radiation therapy (XRT) to ORN development significantly predicted for flap‐specific complications and flap loss (p < .05). Increased time from ORN diagnosis to flap surgery resulted in greater length of bone involvement (p = .01). Anastomotic complications occurred in 13 cases resulting in 7 complete flap losses.Conclusion.An increased risk of complication was encountered with greater time from XRT to ORN. Thus, in patients developing ORN long after treatment, surgery should be accordingly more aggressive. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Serum IL10 and circulating CD4+CD25high regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma
Authors: Alhamarneh Osama , Agada Frank , Madden Leigh , Stafford Nicholas , Greenman John 
Published: July 2010

AbstractBackground.Patients with head and neck squamous cell carcinoma (HNSCC) commonly have an imbalance in T helper (Th)1/Th2‐type cytokines and elevated levels of CD4+CD25high regulatory T cells (Treg). Here, we investigated the association of circulating interleukin (IL)10, IL12, and Treg‐cells with clinical outcome in patients with HNSCC.Methods.Serum cytokine levels were determined by enzyme‐linked immunosorbent assay (ELISA) in patients' pretreatment (n = 107) and 4 to 6 weeks posttreatment (n = 43), and in nontumor controls (n = 40). Treg‐cell levels were determined by flow cytometry.Results.IL10 detectability was significantly higher in patients than controls (p = .001). Pretreatment IL10 levels in all anatomical subsites, except the oral cavity, were significantly elevated in stages III/IV, N+ patients, and in T3/4‐tumors (p = .005, .037, and .001, respectively). The detectability of IL10 significantly correlated with poorer survival after a maximum follow‐up of 36 months. Treg‐cell levels did not correlate with any clinical parameters.Conclusion.IL10 is a potential independent factor in predicting a poor clinical outcome in newly presenting tumors of laryngeal and pharyngeal origin. The role of circulating Treg‐cells as predictors of clinical outcome requires further investigation. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Selective culture of different types of human parotid gland cells
Authors: Chan Yen‐Hui , Huang Tsung‐Wei , Young Tai‐Horng , Lou Pei‐Jen 
Published: July 2010

AbstractBackground.Advances in salivary gland tissue engineering can benefit patients diagnosed with xerostomia. Complexity of the gland explains the urgent demand for a reliable protocol to isolate and expand various gland cells that can be used for further study.Methods.Three cells with different morphologies were isolated from the same human parotid glands using different culture medium systems and then were identified by the expressions from mRNA to the protein level.Results.Among the 34 specimens, parotid gland acinar cells, myoepithelial cells, and fibroblasts expressing specific markers that belonged to individual cell types, were successfully isolated and expanded from 30 specimens without a complex mechanical process and expensive flow technique.Conclusion.The proposed protocol is simple with a high success rate to culture various gland cells, making it highly promising for use in future tissue engineering studies. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing “targeted” MRI with the histologic findings following surgery
Authors: Gandhi M. R. , Panizza B. , Kennedy D. 
Published: July 2010

AbstractBackground.The accurate preoperative identification of the extent of perineural spread (PNS) of malignancy along a cranial nerve is vital to the design of an appropriate surgical resection. Our purpose was to determine the sensitivity of targeted MRI in predicting the presence of disease and the anatomic extent of spread when compared with histologic findings.Methods.A retrospective review was performed of 25 patients with PNS who had targeted MRI and surgery to excise perineural tumor (2002–2008).Results.MRI detected PNS in 30 of 30 nerves (100%) with 1 false positive. MRI correctly identified the extent of spread based on histology in 25 of 30 nerves (83.3%). In 4 of 30 cases (13.3%) MRI underestimated the extent of spread proximal to the Gasserian ganglion that, if diagnosed preoperatively, may have deemed the patient inoperable.Conclusions.MRI demonstrated the presence and anatomic extent of PNS in the majority of cases. MRI may underestimate microscopic spread proximal to the Gasserian ganglion. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Entrepreneurial human resource leadership: A conversation with Dwight Carlson
Authors: Strubler David C. , Redekop Benjamin W. 
Published: July 2010

AbstractIn his blunt and engaging manner, visionary entrepreneur Dwight Carlson has insightful and provocative things to say about leadership, communication and team development, and motivation. We argue that Carlson is an “entrepreneurial leader” who has learned how to create an environment that fosters innovation, hard work, a sense of fun, and “team spirit” and which results in highly motivated and productive staff. At the same time, we recognize that not all entrepreneurs necessarily share Carlson's “bravado.” Nevertheless, his example as founder and CEO of several high‐tech start‐up companies sheds light on the unique contours of entrepreneurial human resource leadership. © 2010 Wiley Periodicals, Inc.
Managing temporary workers by defining temporary work agency service quality
Authors: Liu Chung‐Tzer , Wu Cindy , Hu Chun‐Wei 
Published: July 2010

AbstractThis study investigates and defines the concept of service quality of a temporary work agency (TWA) from the perspective of temporary workers as the TWA's internal customers. Specifically, we conducted two surveys using two separate samples of temporary workers to (1) develop a measure of TWA service quality based on service literature and (2) test the newly developed measure's reliability, factor structure, and validity. Exploratory factor analysis and confirmatory factor analysis results show that an effective temporary work agency is one that offers reliable placement services, appears interpersonally supportive in interacting with the temporary workers, provides individualized and customized service, is furnished with appealing tangible facilities and equipment, and offers services that are conveniently accessible before, during, and after the temporary job assignments. Structural equation modeling results further suggest that TWA service quality is directly related to temporary workers' customer satisfaction with the TWA and perceived TWA service value and is indirectly related to temporary workers' customer loyalty to the TWA. Research and practical implications of this research are discussed. © 2010 Wiley Periodicals, Inc.
Using social exchange theory to predict the effects of high‐performance human resource practices on corporate entrepreneurship: Evidence from China
Authors: Zhang Zhe , Jia Ming 
Published: July 2010

AbstractUsing the foundation of social exchange theory, we examined underlying mechanisms linking the relationship of high‐performance human resource practices and corporate entrepreneurship (CE). Specifically, we explore why and under what conditions these two concepts are related. A multilevel analysis of data from biotechnology pharmaceutical enterprises in the People's Republic of China revealed that employees' perceived organizational support (POS) mediated the relationship between high‐performance human resource practices and CE. Further, organizational culture moderates the relationship between high‐performance human resource practices and employees' POS. The implications of these findings for both management theory and practice are discussed. © 2010 Wiley Periodicals, Inc.
Climate impacts on river flow: projections for the Medway catchment, UK, with UKCP09 and CATCHMOD
Authors: Cloke H. L. , Jeffers C. , Wetterhall F. , Byrne T. , Lowe J. , Pappenberger F. 
Published: July 2010

AbstractThe potential impact of climate change on areas of strategic importance for water resources remains a concern. Here, river flow projections for the River Medway, above Teston in southeast England are presented, which is just such an area of strategic importance. The river flow projections use climate inputs from the Hadley Centre Regional Climate Model (HadRM3) for the time period 1960–2080 (a subset of the early release UKCP09 projections). River flow predictions are calculated using CATCHMOD, the main river flow prediction tool of the Environment Agency (EA) of England and Wales. In order to use this tool in the best way for climate change predictions, model setup and performance are analysed using sensitivity and uncertainty analysis. The model's representation of hydrological processes is discussed and the direct percolation and first linear storage constant parameters are found to strongly affect model results in a complex way, with the former more important for low flows and the latter for high flows. The uncertainty in predictions resulting from the hydrological model parameters is demonstrated and the projections of river flow under future climate are analysed. A clear climate change impact signal is evident in the results with a persistent lowering of mean daily river flows for all months and for all projection time slices. Results indicate that a projection of lower flows under future climate is valid even taking into account the uncertainties considered in this modelling chain exercise. The model parameter uncertainty becomes more significant under future climate as the river flows become lower. This has significant implications for those making policy decisions based on such modelling results. Copyright © 2010 John Wiley & Sons, Ltd.
Using a H∞ filter assimilation procedure to estimate root zone soil water content
Authors: Lü Haishen , Li Xiaoli , Yu Zhongbo , Horton Robert , Zhu Yonghua , Hao Zhenchun , Xiang Long 
Published: July 2010

AbstractRoot zone soil water content impacts plant water availability, land energy and water balances. Because of unknown hydrological model error, observation errors and the statistical characteristics of the errors, the widely used Kalman filter (KF) and its extensions are challenged to retrieve the root zone soil water content using the surface soil water content. If the soil hydraulic parameters are poorly estimated, the KF and its extensions fail to accurately estimate the root zone soil water. The H‐infinity filter (HF) represents a robust version of the KF. The HF is widely used in data assimilation and is superior to the KF, especially when the performance of the model is not well understood. The objective of this study is to study the impact of uncertain soil hydraulic parameters, initial soil moisture content and observation period on the ability of HF assimilation to predict in situ soil water content. In this article, we study seven cases. The results show that the soil hydraulic parameters hold a critical role in the course of assimilation. When the soil hydraulic parameters are poorly estimated, an accurate estimation of root soil water content cannot be retrieved by the HF assimilation approach. When the estimated soil hydraulic parameters are similar to actual values, the soil water content at various depths can be accurately retrieved by the HF assimilation. The HF assimilation is not very sensitive to the initial soil water content, and the impact of the initial soil water content on the assimilation scheme can be eliminated after about 5–7 days. The observation interval is important for soil water profile distribution retrieval with the HF, and the shorter the observation interval, the shorter the time required to achieve actual soil water content. However, the retrieval results are not very accurate at a depth of 100 cm. Also it is complex to determine the weighting coefficient and the error attenuation parameter in the HF assimilation. In this article, the trial‐and‐error method was used to determine the weighting coefficient and the error attenuation parameter. After the first establishment of limited range of the parameters, ‘the best parameter set’ was selected from the range of values. For the soil conditions investigated, the HF assimilation results are better than the open‐loop results. Copyright © 2010 John Wiley & Sons, Ltd.
Estimating the deep seepage component of the hillslope and catchment water balance within a measurement uncertainty framework
Authors: Graham Chris B. , van Verseveld Willem , Barnard Holly R. , McDonnell Jeffrey J. 
Published: July 2010

AbstractDeep seepage is a term in the hillslope and catchment water balance that is rarely measured and usually relegated to a residual in the water balance equation. While recent studies have begun to quantify this important component, we still lack understanding of how deep seepage varies from hillslope to catchment scales and how much uncertainty surrounds its quantification within the overall water balance. Here, we report on a hillslope water balance study from the H. J. Andrews Experimental Forest in Oregon aimed at quantifying the deep seepage component where we irrigated a 172‐m2 section of hillslope for 24·4 days at 3·6 ± 3 mm/h. The objective of this experiment was to close the water balance, identifying the relative partitioning of, and uncertainties around deep seepage and the other measured water balance components of evaporation, transpiration, lateral subsurface flow, bedrock return flow and fluxes into and out of soil profile storage. We then used this information to determine how the quantification of individual water balance components improves our understanding of key hillslope processes and how uncertainties in individual measurements propagate through the functional uses of the measurements into water balance components (i.e. meteorological measurements propagated through potential evapotranspiration estimates). Our results show that hillslope scale deep seepage composed of 27 ± 17% of applied water. During and immediately after the irrigation experiment, a significant amount of the irrigation water could not be accounted for. This amount decreased as the measurement time increased, declining from 28 ± 16% at the end of the irrigation to 20 ± 21% after 10 days drainage. This water is attributed to deep seepage at the catchment scale. Copyright © 2010 John Wiley & Sons, Ltd.
Long‐term hydrologic simulation using SCS‐CN‐based improved soil moisture accounting procedure
Authors: Durbude Dilip G. , Jain Manoj K. , Mishra Surendra K. 
Published: July 2010

AbstractThe Soil Conservation Service Curve Number (SCS‐CN) method is widely used in determination of direct surface run‐off in long‐term (continuous) hydrologic simulation models. Of late, Michel et al. (2005) reviewed the soil moisture accounting (SMA) procedure that lies behind the original SCS‐CN method and pointed out severe structural inconsistencies in the treatment of antecedent condition and, in turn, proposed a sounder methodology. However, this method still needs refinement in the definition of initial moisture level (V0) to make it usable in field. Thus, in the present study, the Michel et al. (2005) model is modified to avoid the unrealistic sudden jump in V0 by incorporating conceptual SMA procedure and variation of daily CN based on antecedent moisture amount instead of antecedent moisture condition. When applied to 17 watersheds from different agro‐climatic regions of India, the proposed model simulates daily stream flows better than those due to Michel et al. model. The proposed model performed better in high run‐off producing (wet) watersheds than in low run‐off producing (dry) watersheds, and the base flow was more and less significant in high and low run‐off producing watersheds, respectively, whereas the evapotranspiration showed a reverse trend. Copyright © 2010 John Wiley & Sons, Ltd.
Correlation between thermal conductivity and bond length alternation in carbon nanotubes: A combined reverse nonequilibrium molecular dynamics—Crystal orbital analysis
Authors: Alaghemandi Mohammad , Schulte Joachim , Leroy Frédéric , Müller‐plathe Florian , Böhm Michael C. 
Published: July 2010

AbstractThe thermal conductivity (λ) of carbon nanotubes (CNTs) with chirality indices (5,0), (10,0), (5,5), and (10,10) has been studied by reverse nonequilibrium molecular dynamics (RNEMD) simulations as a function of different bond length alternation patterns (Δri). The Δri dependence of the bond force constant (krx) in the molecular dynamics force field has been modeled with the help of an electronic band structure approach. These calculations show that the Δri dependence of krx in tubes with not too small a diameter can be mapped by a simple linear bond length–bond order correlation. A bond length alternation with an overall reduction in the length of the nanotube causes an enhancement of λ, whereas an alternation scheme leading to an elongation of the tube is coupled to a decrease of the thermal conductivity. This effect is more pronounced in carbon nanotubes with larger diameters. The formation of a polyene‐like structure in the direction of the longitudinal axis has a negligible influence on λ. A comparative analysis of the RNEMD and crystal orbital results indicates that Δri‐dependent modifications of λ and the electrical conductivity are uncorrelated. This behavior is in‐line with a heat transfer that is not carried by electrons. Modifications of λ as a function of the bond alternation in the (10,10) nanotube are explained with the help of power spectra, which provide access to the density of vibrational states. We have suggested longitudinal low‐energy modes in the spectra that might be responsible for the Δri dependence of λ. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010