bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transaortic transcatheter aortic valve implantation within a previous bioprosthetic aortic valve replacement
Authors: Cockburn James , Trivedi Uday , Hildick‐Smith David 
Published: July 2011

AbstractThis report documents the first reported case of transaortic transcatheter aortic valve implantation (TAVI) using the CoreValve ReValving system (Medtronic CoreValve System, Luxembourg), within a previous bioprosthetic aortic valve replacement. TAVI has become a recognized percutaneous treatment for patients with severe native or bioprosthetic aortic valve stenosis. However, as the number of patients screened for TAVI increases, a number of patients are found with absolutely no option for peripheral arterial access, either from the femoral or subclavian routes. Transaortic CoreValve placement offers an alternate minimally invasive hybrid surgical/interventional technique when peripheral access is not possible. A CoreValve prosthesis was implanted via the transaortic route in an 81‐year‐old woman with severe bioprosthetic aortic valve stenosis (21 mm Mitroflow pericardial valve, peak instantaneous gradient of 99 mmHg, effective valve orifice area (EOA) of 0.3 cm2, as ilio‐femoral and left subclavian angiography revealed small calibre vessels (<6 mm). Access was achieved via a mini thoracotomy via the left anterior second intercostal space. The procedure went without complication. Post procedure the patient was transferred directly to the Cardiac Care Unit for recuperation. Post procedure echocardiography showed that the TAVI was well positioned with no para‐valvular leak and a reduction in peak instantaneous gradient to 30 mmHg and an increase in EOA to 1.5 cm2. She was discharged on the third post‐procedural day in sinus rhythm with a narrow QRS complex. CoreValve implantation within previous surgical bioprosthesis is now an established treatment. The transaortic approach to transcatheter implantation is a promising recent development, when due to anatomical reasons, transfemoral or subclavian TAVI is not feasible. © 2011 Wiley‐Liss, Inc.
Hydrocracking of Anthracene to Ethyl Biphenyl Promoted by Coupling Supercritical Water and Cracking Catalysts
Authors: Fan Honglei , Han Buxing , Jiang Tao , Guo Jin , Wang Qian , Cheng Yan , Wu Suxiang 
Published: July 2011

AbstractEfficient conversion of polynuclear aromatic hydrocarbons (PAHs) into liquid fuels is crucial for the hydrocracking processes of heavy oils. In this work, we found that the hydrocracking of anthracene catalyzed by NiFe/HZSM‐5 could produce ethyl biphenyl (EB), which realizes high efficiency of hydrocracking of anthracene analogous to its central‐ring hydrocracking. More interestingly, addition of water could increase the yield of EB significantly, and the yield of EB could be as high as 34 %. A pathway for hydrocracking of anthracene to EB and the mechanism for water to enhance the yield of EB are proposed on the basis of control experiments. Furthermore, our work demonstrated that water could also increase the liquid yields and reduce the gaseous yields in the hydrocracking of the Daqing residue oil in the same reaction system. This work not only provides new chemical knowledge on hydrocracking of PAHs, but also provides very important information for improving the hydrocracking processes of heavy oils to obtain more liquid fuels with less hydrogen consumption.
Unusually Long, Multicenter, Cationδ+⋅⋅⋅Anionδ−Bonding Observed for Several Polymorphs of [TTF][TCNE]
Authors: Capdevila‐Cortada Marçal , Novoa Juan J. , Bell Joshua D. , Moore Curtis E. , Rheingold Arnold L. , Miller Joel S. 
Published: July 2011

AbstractThe α, β, and δ polymorphs of [TTF][TCNE] (TTF=tetrathiafulvalene; TCNE=tetracyanoethylene) exhibit a new type of long, multicenter bonding between the [TTF]δ+and [TCNE]δ−moieties, demonstrating the existence of long, hetero‐multicenter bonding with a cationicδ+⋅⋅⋅anionicδ−zwitterionic‐like structure. These diamagnetic π‐[TTF]δ+[TCNE]δ−heterodimers exhibit a transfer of about 0.5 e−from the TTF to the TCNE fragments, as observed from experimental studies, in accord with theoretical predictions, that is, [TTFδ+⋅⋅⋅TCNEδ−] (δ≅0.5). They have several interfragment distances <3.4 Å, and a computed interaction energy of −21.2 kcal mol−1, which is typical of long, multicenter bonds. The lower stability of [TTF]δ+[TCNE]δ−with respect to typical ionic bonds is due, in part, to the partial electron transfer that reduces the electrostatic bonding component. This reduced electrostatic interaction, and the large interfragment dispersion stabilize the long, heterocationic/anionic multicenter interaction, which in [TTFδ+⋅⋅⋅TCNEδ−] always involves two electrons, but have ten, eight, and eight bond critical points (bcps) involving CC, NS, and sometimes CS and CN components for the α, β, and δ polymorphs, respectively. In contrast, γ‐[TTF][TCNE] possesses [TTF]22+and [TCNE]22−dimers, each with long, homo‐multicenter 2e−/12c (c=center, 2 C+4 S) [TTF]22+cationic+⋅⋅⋅cationic+bonds, as well as long, homo‐multicenter 2e−/4c [TCNE]22−anionic−⋅⋅⋅anionic−bonding. The MO diagrams for the α, β, and δ polymorphs have all of the features found for conventional covalent CC bonds, and for all of the previously studied multicenter long bonds, for example, π‐[TTF]22+and π‐[TCNE]22−. The HOMOs for α‐, β‐, and δ‐[TTF][TCNE] have 2c CS and 3c CCC orbital‐overlap contributions between the [TTF]δ+−and [TCNE]δ−moieties; these are the shortest intra [TTF⋅⋅⋅TCNE] separations. Thus, from an orbital‐overlap perspective, the bonding has 2c and 3c components residing over one S and four C atoms.
Thermodynamic analysis of hydrogen production from glycerol at energy self‐sufficient conditions
Authors: Pairojpiriyakul Thirasak , Kiatkittipong Worapon , Soottitantawat Apinan , Arpornwichanop Amornchai , Laosiripojana Navadol , Wiyaratn Wisitsree , Croiset Eric , Assabumrungrat Suttichai 
Published: July 2011

AbstractA thermodynamic analysis based on the principle of minimising the Gibbs free energy is performed for hydrogen production from glycerol. When the operating parameters such as water/glycerol ratio (WGR), oxygen/glycerol ratio (OGR) and operating temperature (T) are carefully chosen, the energy self‐sufficient conditions can be achieved. Two levels of energy self‐sufficient, (i) within the reformer and (ii) within the overall system, are considered. Unlike the consideration in the reformer level reported in most works in literature, the consideration in the overall system level represents more realistic results based on the fact that some energy is required for heating up the feeds to a desired operating temperature. The obtained results demonstrate that the maximum hydrogen production significantly decreases from 5.65 mol H2/mol glycerol for the reformer level to 3.31 mol H2/mol glycerol for the system level, emphasising the significant demand of energy for feed preheating. © 2011 Canadian Society for Chemical Engineering
Analysis of surfactant laden liquid–liquid dispersion using an axisymmetric laminar jet
Authors: Walker Justin R. , Calabrese Richard V. 
Published: July 2011

AbstractThe contacting of multiple liquid phases is a complex process; and one that is often difficult to study experimentally. However, many multiphase mixers function by forcing an immiscible fluid through an orifice or nozzle, which can be modelled using an axisymmetric jet. Despite the extensive literature on jets, there is little information on the role played by surfactants in determining jet breakup length and drop diameter.Experiments involving the discharge of oil jets into otherwise quiescent aqueous surfactant solutions were performed over a broad range of conditions. Jet length was found to increase with surfactant concentration, while droplet diameter was found to decrease (dependent on jet regime). These results compare favourably with, and can aid the interpretation of similar experiments in high shear mixers.
Cost‐effectiveness of epidermal growth factor receptor mutation testing and first‐line treatment with gefitinib for patients with advanced adenocarcinoma of the lung
Authors: de Lima Lopes Gilberto , Segel Joel E. , Tan Daniel S. W. , Do Young K. , Mok Tony , Finkelstein Eric A. 
Published: July 2011

AbstractBACKGROUND:Epidermal growth factor receptor (EGFR) testing and first‐line therapy with gefitinib for patients with activating mutations is quickly becoming the standard option for the treatment of advanced lung adenocarcinoma. Yet, to date, little is known about the cost‐effectiveness of this approach.METHODS:A decision‐analytic model was developed to determine the cost‐effectiveness of EGFR testing and first‐line treatment with gefitinib for those patients who harbor activating mutations versus standard care, which includes first‐line treatment with chemotherapy followed by gefitinib as second‐line treatment. The model uses clinical and outcomes data from randomized clinical trials and societal costs from Singapore cancer centers. Health effects were expressed as quality‐adjusted life‐years. All costs and cost‐effectiveness ratios were expressed in 2010 Singapore dollars. Sensitivity and different scenarios analyses were conducted.RESULTS:EGFR testing and first‐line treatment with gefitinib is a dominant strategy (with lower costs and greater effectiveness) compared with standard care. Because the primary savings result from not providing gefitinib to those who are not likely to benefit, this finding holds regardless of the prevalence of activating mutations. In a secondary analysis, first‐line treatment with gefitinib was also dominant when compared with first‐line chemotherapy in patients with activating EGFR mutations.CONCLUSIONS:This strategy can be considered a new standard of care and should be of great interest for health care payers and decision makers in an era in which our greatest challenge is to balance hard‐won and incremental, yet small, improvements in patient outcomes with exponentially rising costs. Cancer 2012;. © 2011 American Cancer Society.
The extended connection‐dependent threshold model for call‐level performance analysis of multi‐rate loss systems under the bandwidth reservation policy
Authors: Vassilakis Vassilios G. , Moscholios Ioannis D. , Logothetis Michael D. 
Published: July 2011

SUMMARYFirstly, we reviewed two extensions of the Erlang multi‐rate loss model, whereby we can assess the call‐level QoS of telecom networks supporting elastic traffic: (i) the extended Erlang multi‐rate loss model, where random arriving calls of certain bandwidth requirements at call setup can tolerate bandwidth compression while in service; and (ii) the connection‐dependent threshold model, where arriving calls may have several contingency bandwidth requirements, whereas in‐service calls cannot tolerate bandwidth compression. Secondly, we proposed a new model, the extended connection‐dependent threshold model. Calls may have alternative bandwidth requirements at call setup and can tolerate bandwidth compression while in service. We proposed a recurrent formula for the efficient calculation of link occupancy distribution and consequently call blocking probabilities, link utilization, and throughput per service class. Furthermore, in the proposed model, we incorporated the bandwidth reservation policy, whereby we can (i) equalize the call blocking probabilities of different service classes, (ii) guarantee specific QoS per service class, and (iii) implement different maximum bandwidth compression/expansion rate per service class so that the network supports both elastic and stream traffic. The accuracy of the new model is verified by simulation. Moreover, the proposed model performs better than the existing models. Finally, we generalize the proposed model by incorporating service classes with either random or quasi‐random arrivals. Copyright © 2011 John Wiley & Sons, Ltd.
1,25‐Dihydroxyvitamin D3 enhances NK susceptibility of human melanoma cells via Hsp60‐mediated FAS expression
Authors: Lee Ji H. , Park Sunyoung , Cheon Soyoung , Lee Joo H. , Kim Sunghan , Hur Dae Y. , Kim Tae S. , Yoon Suk R. , Yang Yoolhee , Bang Sa I. , Park Hyunjeong , Lee Hoon T. , Cho Daeho 
Published: July 2011

AbstractThe active metabolite of vitamin D3, 1α,25(OH)2D3, displays anticancer effects by regulating cell cycle and apoptosis in many cancer cells. However, it has not been determined whether 1α,25(OH)2D3 increases the susceptibility of cancer cells to NK cells. Here, we investigated the anticancer effect of 1α,25(OH)2D3 in human melanoma cell lines by investigating enhancement of NK susceptibility and elucidating the mediator of NK cytotoxicity. 1α,25(OH)2D3‐resistant melanoma cells (G‐361 and SK‐MEL‐5) treated with 1α,25(OH)2D3 showed higher susceptibility to NK cells with up‐regulation of Fas expression. Furthermore, G‐361 cells treated with 1α,25(OH)2D3 showed significantly increased caspase activity. In addition to Fas up‐regulation, expression of heat shock protein 60 (Hsp60) was elevated by 1α,25(OH)2D3. Increased expression of Hsp60 by 1α,25(OH)2D3 was related to not only up‐regulation of Fas expression but also to NK susceptibility of G‐361 cells. Taken together, our data suggest that 1α,25(OH)2D3 acts as an anticancer agent by increasing expression of Fas on the surface of melanoma cells through Hsp60 induction and strengthens caspase sensitivity to Fas‐mediated apoptotic pathway by NK cells. 1α,25(OH)2D3 treatment may therefore have a preventive role in melanoma occurrence or potentiate the anticancer effects of NK‐cell immune therapy.
Cover Picture: Eur. J. Immunol. 8/11
Authors: Arshad Muhammad I. , Rauch Michel , L'Helgoualc'h Annie , Julia Valérie , Leite‐de‐Moraes Maria C. , Lucas‐Clerc Catherine , Piquet‐Pellorce Claire , Samson Michel 
Published: July 2011

AbstractA cryosection of the liver taken from a mouse treated with concanavalin A to induce acute hepatitis features on this issue's cover; the section is stained with Hoechst, Texas red‐phalloidin and anti‐mIL‐33 goat IgG/Cy5‐conjugated secondary antibody, identifying the nuclei in blue, F‐actin filaments in orange and IL‐33‐expressing cells in green respectively. The image is taken from the article by Arshad et al. (pp. 2341–2349) in which the induction of IL‐33 expression in hepatocytes in concanavalin A‐induced hepatitis is suggested to be driven by NKT cells.
Formation of Chiral Heteronuclear LnIII Assemblies by Ion Pair Formation
Authors: Gregoliński Janusz , Wieczorek Robert , Lisowski Jerzy 
Published: July 2011

AbstractCationic LnIII complexes with the chiral macrocycle L, (P)‐[LnLRRRRRR]3+, interact with anionic LnIII tris(dipicolinate) complexes, [Ln′(dpa)3]3–, forming tight hydrogen‐bonded ion pairs in solution. Formation of these pairs has been documented by the DFT calculations, and a strong paramagnetic shift of the signals of the diamagnetic cation interacting with the paramagnetic anion was observed. This ion pair interaction leads to spectral enantiodifferentiation of the Λ‐[Ln′(dpa)3]3– and Δ‐[Ln′(dpa)3]3– enantiomers of the anionic complex.Although no Pfeiffer effect was observed for the (P)‐[LnLRRRRRR]3+ diastereomers of the cationic complex, the (M)‐[LnLRRRRRR]3+ diastereomers induce CD signals in the anionic [Ln′(dpa)3]3– partner. These spectra indicate a Pfeiffer effect, i.e. a shift of equilibrium between the Λ‐[Ln′(dpa)3]3– and Δ‐[Ln′(dpa)3]3– enantiomers. This effect arises from the ion pair interaction between the anionic complex [Ln′(dpa)3]3– and the intact cationic complex as well as between [Ln′(dpa)3]3– and L. The protonated macrocycle (H3LRRRRRR)3+ forms highly insoluble salts with [Ln′(dpa)3]3–. These supramolecular compounds are formed by the reaction of L, acids and [Ln′(dpa)3]3– anions. The same product can also be formed by the reaction of (M)‐[LnLRRRRRR]3+ with three equivalents of dipicolinic acid. The model structure of (H3LRRRRRR)[Ln′(dpa)3] corresponds with a linear polymer with alternate cationic macrocycles and anionic [Ln′(dpa)3]3– complexes interacting through charge interactions and multiple hydrogen bonds.
Synthesis and Structural Characterization of Lithium and Iron Complexes Containing a Chelating Phenolate Phosphane Ligand
Authors: Liang Lan‐Chang , Chang Yu‐Ning , Shih Huan‐Yu , Lin Sheng‐Ta , Lee Hon Man 
Published: July 2011

AbstractThe preparation and characterization of lithium and iron(II) complexes containing a potentially tridentate biphenolate phosphane ligand are reported. Deprotonation of 2,2′‐phenylphosphanyl‐bis(4,6‐di‐tert‐butylphenol) (H2LPh) with one or two equivalents of nBuLi in diethyl ether solutions at –35 °C produces binuclear {Li(HLPh)(OEt2)}2 or tetranuclear Li4(LPh)2(OEt2)3, respectively. An X‐ray study of {Li(HLPh)(OEt2)}2 showed it to be a Ci‐symmetric dimer composed of two Li(HLPh)(OEt2) units linked with dative O–Li bonds involving phenolate oxygen donor atoms whereas that of Li4(LPh)2(OEt2)3 revealed a C2‐symmetric structure in which the two biphenolate phosphane ligands are linked with four lithium atoms that bind to three diethyl ether molecules. Treatment of FeCl2 with one or two equivalents of Na2(LPh)(DME)2 in THF at –35 °C generates binuclear Fe2(LPh)2(THF)2 or mononuclear Fe(HLPh)2(THF)2, respectively. The two iron(II) centers in Fe2(LPh)2(THF)2 are antiferromagnetically coupled.
Low‐Temperature Hydrothermal Synthesis of Ultrafine Strontium Hexaferrite Nanoparticles
Authors: Primc Darinka , Drofenik Miha , Makovec Darko 
Published: July 2011

AbstractUltrafine strontium hexaferrite (SrFe12O19) nanoparticles have been synthesized by the hydrothermal treatment of an appropriate suspension of Sr and Fe hydroxides in the presence of a large excess of OH– at temperatures between 130 and 170 °C. To avoid the parallel formation of any undesired hematite (α‐Fe2O3) during the synthesis, a large excess of Sr in the starting composition (Fe/Sr = 3) had to be used. When the treatment was performed below 170 °C, ultrafine nanoparticles were formed. The TEM images show they have a disc‐like shape, approximately 12 nm wide, but only around 4 nm thick. The EDS analysis showed their composition corresponded to SrFe12O19. When the temperature of the hydrothermal treatment exceeded 170 °C, larger hexagonal platelet crystals appeared as a consequence of Ostwald ripening. The evolution of the size and morphology of the nanoparticles with the temperature of the hydrothermal treatment was also monitored by XRD and measurement of the magnetic properties.
Combination of Rearrangement with Metallic and Organic Catalyses – a Step‐ and Atom‐Economical Approach to α‐Spiroactones and ‐lactams
Authors: Boddaert Thomas , Coquerel Yoann , Rodriguez Jean 
Published: July 2011

AbstractA general synthetic route to α‐spirolactones and ‐lactams from 2‐diazo‐1,3‐dicarbonyl compounds, (homo)allylic alcohols or amines and acrylic derivatives, involving a single consecutive reaction consisting of a Wolff rearrangement/α‐oxo ketene trapping/cross metathesis/Michael addition sequence is described. During the consecutive reaction optimization, the organocatalytic activity of N,N‐diaryl‐1,3‐imidazol(in)‐2‐ylidene N‐heterocyclic carbenes (NHCs) in the Michael addition of 1,3‐dicarbonyl compounds was discovered. A conceptually attractive version of the consecutive reaction was then developed, involving the Grubbs–Hoveyda ruthenium‐based precatalyst containing the SIMes [1,3‐bis(2,4,6‐trimethylphenyl)imidazolin‐2‐ylidene] NHC ligand as the source of both the organometallic catalyst of the cross metathesis and the organic catalyst of the intramolecular Michael addition.
Metabolomic assessment with CE‐MS of the nutraceutical effect of Cystoseira spp extracts in an animal model
Authors: Moraes Edgar P. , Rupérez Francisco Javier , Plaza Merichel , Herrero Miguel , Barbas Coral 
Published: July 2011

AbstractThere is a need of scientific evidence of claimed nutraceutical effects, but also there is a social movement towards the use of natural products and among them algae are seen as rich resources. Within this scenario, the development of methodology for rapid and reliable assessment of markers of efficiency and security of these extracts is necessary. The rat treated with streptozotocin has been proposed as the most appropriate model of systemic oxidative stress for studying antioxidant therapies. Cystoseira is a brown alga containing fucoxanthin and other carothenes whose pressure‐assisted extracts were assayed to discover a possible beneficial effect on complications related to diabetes evolution in an acute but short‐term model. Urine was selected as the sample and CE‐TOF‐MS as the analytical technique to obtain the fingerprints in a non‐target metabolomic approach. Multivariate data analysis revealed a good clustering of the groups and permitted the putative assignment of compounds statistically significant in the classification. Interestingly a group of compounds associated to lysine glycation and cleavage from proteins was found to be increased in diabetic animals receiving vehicle as compared to control animals receiving vehicle (N6,N6,N6‐trimethyl‐L‐lysine, N‐methylnicotinamide, galactosylhydroxylysine, L‐carnitine, N6‐acetyl‐N6‐hydroxylysine, fructose‐lysine, pipecolic acid, urocanic acid, amino‐isobutanoate, formylisoglutamine. Fructoselysine significantly decreased after the treatment changing from a 24% increase to a 19% decrease. CE‐MS fingerprinting of urine has provided a group of compounds different to those detected with other techniques and therefore proves the necessity of a cross‐platform analysis to obtain a broad view of biological samples.
Anaerobic digestion of flower waste for methane production: An alternative energy source
Authors: Singh Puja , Bajpai Usha 
Published: July 2011

AbstractThe waste generated in temples is presently piled at one place and then disposed off in water bodies or dumped on land to decay which causes several environmental problems such as water, soil pollution, etc. The aim of the paper is to determine the biogas yield by using temple waste as a raw material. A prototype experimental setup has been developed to find the quality of biogas produced by flower waste with the help of gas chromatographer. The experiment was conducted during cold months in the composite climatic conditions of Lucknow, India. Prototype digesters of 2 m3 capacity were used and fed with flower waste which was digested in daily feeding for a retention period of summer and winter seasons. Preliminary results indicate that the process is effective in reducing the pollution potential of the flower waste. The process removed a lot of environmental pollutants as total solids, biochemical oxygen demand (BOD), etc. respectively, along with biogas production. The results of the biogas from flower waste were compared as 43%–50% methane (CH4) and 44%–50% carbon dioxide (CO2) during winter season (December to February) and 50%–54% methane (CH4) and 40%–43% carbon dioxide (CO2) during summer season (March to May). © 2011 American Institute of Chemical Engineers Environ Prog, 2011