bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized clinical trial of endoluminal locoregional resection versus laparoscopic total mesorectal excision for T2 rectal cancer after neoadjuvant therapy
Authors: Lezoche E , Baldarelli M , Lezoche G , Paganini A M , Gesuita R , Guerrieri M 
Published: August 2012

Abstract

Background
In selected patients with early low rectal cancer, locoregional excision combined with neoadjuvant therapy may be an alternative treatment option to total mesorectal excision (TME).

Methods
This prospective randomized trial compared endoluminal locoregional resection (ELRR) by transanal endoscopic microsurgery versus laparoscopic TME in the treatment of patients with small non-advanced low rectal cancer. Patients with rectal cancer staged clinically as cT2 N0 M0, histological grade G1–2, with a tumour less than 3 cm in diameter, within 6 cm of the anal verge, were randomized to ELRR or TME. All patients underwent long-course neoadjuvant chemoradiotherapy.

Results
Fifty patients in each group were analysed. Overall tumour downstaging and downsizing rates after neoadjuvant chemoradiotherapy were 51 and 26 per cent respectively, and were similar in both groups. All patients had R0 resection with tumour-free resection margins. At long-term follow-up, local recurrence had developed in four patients (8 per cent) after ELRR and three (6 per cent) after TME. Distant metastases were observed in two patients (4 per cent) in each group. There was no statistically significant difference in disease-free survival (P = 0·686).

Conclusion
In selected patients, ELRR had similar oncological results to TME. Unique Protocol ID: URBINO-LEZ-1995; registration number: NCT01609504 (http://www.clinicaltrials.gov).
Real-time computed tomography-based augmented reality for natural orifice transluminal endoscopic surgery navigation
Authors: Azagury D E , Ryou M , Shaikh S N , San José Estépar R , Lengyel B I , Jagadeesan J , Vosburgh K G , Thompson C C 
Published: August 2012

Abstract

Background
Natural orifice transluminal endoscopic surgery (NOTES) is technically challenging owing to endoscopic short-sighted visualization, excessive scope flexibility and lack of adequate instrumentation. Augmented reality may overcome these difficulties. This study tested whether an image registration system for NOTES procedures (IR-NOTES) can facilitate navigation.

Methods
In three human cadavers 15 intra-abdominal organs were targeted endoscopically with and without IR-NOTES via both transgastric and transcolonic routes, by three endoscopists with different levels of expertise. Ease of navigation was evaluated objectively by kinematic analysis, and navigation complexity was determined by creating an organ access complexity score based on the same data.

Results
Without IR-NOTES, 21 (11·7 per cent) of 180 targets were not reached (expert endoscopist 3, advanced 7, intermediate 11), compared with one (1 per cent) of 90 with IR-NOTES (intermediate endoscopist) (P = 0·002). Endoscope movements were significantly less complex in eight of the 15 listed organs when using IR-NOTES. The most complex areas to access were the pelvis and left upper quadrant, independently of the access route. The most difficult organs to access were the spleen (5 failed attempts; 3 of 7 kinematic variables significantly improved) and rectum (4 failed attempts; 5 of 7 kinematic variables significantly improved). The time needed to access the rectum through a transgastric approach was 206·3 s without and 54·9 s with IR-NOTES (P = 0·027).

Conclusion
The IR-NOTES system enhanced both navigation efficacy and ease of intra-abdominal NOTES exploration for operators of all levels. The system rendered some organs accessible to non-expert operators, thereby reducing one impediment to NOTES procedures.
Randomized clinical trial of robot-assisted versus standard laparoscopic right colectomy
Authors: Park J S , Choi G-S , Park S Y , Kim H J , Ryuk J P 
Published: August 2012

Abstract

Background
Robotic surgery was invented to overcome the demerits of laparoscopic technique. However, it is unclear whether robot-assisted colectomy (RAC) has significant clinical advantages over laparoscopically assisted colectomy (LAC) in treating colonic cancer. The aim of this study was to compare the surgical outcomes of RAC versus LAC for right-sided colonic cancer.

Methods
Patients with right-sided colonic cancer were randomized to receive RAC or LAC. The primary outcome measure was length of hospital stay. Secondary outcomes were duration of operation, morbidity, postoperative pain, hospital costs and pathological quality of the specimen.

Results
Of 71 patients randomized, 70 (35 in each group) were included in the analysis. Hospital stay, surgical complications, postoperative pain score, resection margin clearance and number of lymph nodes harvested were similar in both groups. The duration of surgery was longer in the RAC group (195 versus 130 min; P &lt; 0·001). No conversion to open surgery was needed in either group. Overall hospital costs were significantly higher for RAC (US $ 12 235 versus $ 10 320; P = 0·013); the higher costs were attributed primarily to the costs of surgery, including consumables.

Conclusion
Robotic-assisted laparoscopic right colectomy was feasible but provided no benefit to justify the greater cost. Registration number: NCT01042743 (http://www.clinicaltrials.gov).
Repeat hepatic resection for colorectal liver metastases
Authors: Adair R A , Young A L , Cockbain A J , Malde D , Prasad K R , Lodge J P A , Toogood G J 
Published: August 2012

Abstract

Background
Some 75–80 per cent of patients undergoing liver resection for colorectal liver metastases develop intrahepatic recurrence. A significant number of these can be considered for repeat liver surgery. This study examined the outcomes of repeat liver resection for the treatment of recurrent colorectal metastases confined to the liver.

Methods
Patients who underwent repeat liver resection in a single tertiary referral hepatobiliary centre were identified from a database. Clinicopathological variables were analysed to assess factors predictive of survival.

Results
A total of 195 patients underwent repeat resection between 1993 and 2010. Median age was 63 years, and the median interval between first and repeat resection was 13·8 months. Thirty-three patients (16·9 per cent) underwent completion hemihepatectomy or extended hemihepatectomy and the remainder had non-anatomical or segmental resection. The 30-day mortality rate was 1·5 per cent, and the overall 30-day morbidity rate was 20·0 per cent. Overall 1-, 3- and 5-year survival rates were 91·2, 44·3 and 29·4 per cent respectively. Tumour size 5 cm or greater was the only independent predictor of overall survival (relative risk 1·71, 95 per cent confidence interval 1·08 to 2·70; P = 0·021). Neoadjuvant chemotherapy before resection, perioperative blood transfusion, bilobar disease, R1 resection margin and multiple metastases were among factors that did not significantly influence survival.

Conclusion
Repeat hepatic resection remains the only curative option for patients presenting with recurrent colorectal liver metastases.
Intraoperative portal venous pressure and long-term outcome after curative resection for hepatocellular carcinoma
Authors: Hidaka M , Takatsuki M , Soyama A , Tanaka T , Muraoka I , Hara T , Kuroki T , Kanematsu T , Eguchi S 
Published: August 2012

Abstract

Background
Outcomes of liver resection for hepatocellular carcinoma (HCC) have improved owing to better surgical techniques and patient selection. Portal hypertension may influence outcome but the preoperative definition and role of portal hypertension are far from clear. The aim of this study was to elucidate the influence of portal venous pressure (PVP) measured directly during surgery on outcomes of liver resection in patients with HCC.

Methods
Patients who had resection of HCC between 1997 and 2009, and who underwent direct measurement of PVP immediately after laparotomy were enrolled. These patients were divided into groups with high (at least 20 cmH2O) and low (less than 20 cmH2O) PVP. The influence of PVP on overall and recurrence-free survival was analysed and prognostic factors were identified.

Results
A total of 177 patients were enrolled, 129 in the low-PVP group and 48 in the high-PVP group. The 5-year overall survival rate (63·7 versus 31 per cent; P &lt; 0·001) and recurrence-free survival rate (52·5 versus 12 per cent; P &lt; 0·001) were significantly higher in patients with low PVP. In multivariable analysis, two or more tumours, tumour diameter at least 5 cm, high PVP, grade B liver damage and Hepatic Activity Index (HAI) grade 7 or more were significant predictors of poorer survival after liver resection. Two or more tumours, tumour diameter at least 5 cm and HAI grade 7 or more were significant predictors of poorer recurrence-free survival.

Conclusion
High PVP was associated with poor long-term outcome after liver resection for HCC.
Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer
Authors: Sharma Pankaj , Chinaranagari Swathi , Patel Divya , Carey Jason , Chaudhary Jaideep 
Published: August 2012

AbstractThe inhibitor of DNA‐binding (Id) proteins, Id1–4 are negative regulators of basic helix‐loop‐helix (bHLH) transcription factors. As key regulators of cell cycle and differentiation, expression of Id proteins are increasingly observed in many cancers and associated with aggressiveness of the disease. Of all the four Id proteins, the expression of Id1, Id2, and to a lesser extent, Id3 in prostate cancer and the underlying molecular mechanism is relatively well known. On the contrary, our previous results demonstrated that Id4 acts as a potential tumor suppressor in prostate cancer. In the present study, we extend these observations and demonstrate that Id4 is down‐regulated in prostate cancer due to promoter hypermethylation. We used prostate cancer tissue microarrays to investigate Id4 expression. Methylation specific PCR on bisulfite treated DNA was used to determine methylation status of Id4 promoter in laser capture micro‐dissected normal, stroma and prostate cancer regions. High Id4 expression was observed in the normal prostate epithelial cells. In prostate cancer, a stage‐dependent decrease in Id4 expression was observed with majority of high grade cancers showing no Id4 expression. Furthermore, Id4 expression progressively decreased in prostate cancer cell line LNCaP and with no expression in androgen‐insensitive LNCaP‐C81 cell line. Conversely, Id4 promoter hypermethylation increased in LNCaP‐C81 cells suggesting epigenetic silencing. In prostate cancer samples, loss of Id4 expression was also associated with promoter hypermethylation. Our results demonstrate loss of Id4 expression in prostate cancer due to promoter hypermethylation. The data strongly support the role of Id4 as a tumor suppressor.
Initial use of the new GORE® septal occluder in patent foramen ovale closure: Implantation and preliminary results
Authors: MacDonald Simon T. , Daniels Matthew J. , Ormerod Oliver J. 
Published: August 2012

BackgroundA number of devices are available for percutaneous closure of a clinically significant patent foramen ovale (PFO). The new GORE® septal occluder (GSO) is a nonself‐centering device consisting of an expanded polytetrafluoroethylene tube supported by a frame of nitinol wire conforming into a double disk. This study reports the first clinical GSO implantation experience.MethodsGSO implantation in 20 consecutive patients is reported. Inclusion criteria were all patients referred with a significant PFO implicated in paradoxical embolism or transient right to left shunting causing desaturation. Procedures were performed under local anaesthesia and intracardiac echocardiography (ICE) in addition to fluoroscopy. Procedural data, acute and early closure rates were examined.ResultsAll patients underwent successful day‐case device implantation. Eleven patients had previous stroke, five had transient ischemic attacks, two had a history suspicious of PFO‐related desaturation, and two had a history suspicious of PFO‐related peripheral thromboembolism. Acute closure rates on IVC injection bubble testing were 100% at implant and 100% (14/14) at 1 month. Average PFO balloon size was 8.0 ± 3.6(range 2.0–16.7) mm, mean fluoroscopic implantation time 3.0 ± 1.7(range 0.7–6.3) min, radiation dose 283 ± 340 (range 6–1,431) μGym2, and total procedural time 34.8 ± 8.0 (range 22–53) min. 5 × 20 mm2, 7 × 25 m2, 8 × 30 mm2 GSO devices were implanted, aiming for device size at least twice balloon PFO size. Cases included aneurysmal septums with up to 30 mm deviation and tunnels up to 12 mm long. Removal and repositioning of two devices was performed on two occasions after uncertainty about device locking. At 1 month follow‐up, two patients had brief self‐terminating episodes of suspected atrial fibrillation, all had normal resting ECGs. No thromboembolic/neurological events were reported.ConclusionsThe GSO can be implanted under local anaesthesia and ICE with low procedural and fluoroscopy times with high procedural success as a day case. No residual shunts were seen. This initial experience suggests that it is a safe and effective device for PFO closure. © 2012 Wiley Periodicals, Inc.
Solar Fuels: Visible‐Light‐Driven Generation of Dihydrogen at p‐Type Silicon Electrocatalysed by Molybdenum Hydrides
Authors: Webster Lee R. , Ibrahim Saad K. , Wright Joseph A. , Pickett Christopher J. 
Published: August 2012

AbstractWe show that a robust molybdenum hydride system can sustain photoelectrocatalysis of a hydrogen evolution reaction at boron‐doped, hydrogen‐terminated, p‐type silicon. The photovoltage for the system is about 600–650 mV and the current densities, which can be sustained at the photocathode in non‐catalytic and catalytic regimes, are similar to those at a photoinert vitreous carbon electrode. The kinetics of electrocatalysed hydrogen evolution at the photocathode are also very similar to those measured at vitreous carbon—evidently visible light does not significantly perturb the catalytic mechanism. Importantly, we show that the doped (1–10 Ω cm) p‐type Si can function perfectly well in the dark as an ohmic conductor and this has allowed direct comparison of the cyclic voltammetric behaviour of the response of the system under dark and illuminated conditions at the same electrode. The p‐type Si we have employed optimally harvests light energy in the 600–700 nm region and with 37 mW cm−2 illumination in this range; the light to electrochemical energy conversion is estimated to be 2.8 %. The current yield of hydrogen under broad tungsten halide lamp illumination at 90 mW cm−2 is (91±5) % with a corresponding chemical yield of (98±5) %.
Hybrid Mesoporous‐Silica Materials Functionalized by PtII Complexes: Correlation between the Spatial Distribution of the Active Center, Photoluminescence Emission, and Photocatalytic Activity
Authors: Mori Kohsuke , Watanabe Kentaro , Terai Yoshikazu , Fujiwara Yasufumi , Yamashita Hiromi 
Published: August 2012

Abstract[Pt(tpy)Cl]Cl (tpy: terpyridine) was successfully anchored to a series of mesoporous‐silica materials that were modified with (3‐aminopropyl)triethoxysilane with the aim of developing new inorganic–organic hybrid photocatalysts. Herein, the relationship between the luminescence characteristics and photocatalytic activities of these materials is examined as a function of Pt loading to define the spatial distribution of the Pt complex in the mesoporous channel. At low Pt loading, the Pt complex is located as an isolated species and exhibits strong photoluminescence emission at room temperature owing to metal‐to‐ligand charge‐transfer (3MLCT) transitions (at about 530 nm). Energy‐ and/or electron‐transfer from 3MLCT to O2 generate potentially active oxygen species, which are capable of promoting the selective photooxidation of styrene derivatives. On the other hand, short Pt⋅⋅⋅Pt interactions are prominent at high loading and the metal‐metal‐to‐ligand charge‐transfer (3MMLCT) transition is at about 620 nm. Such Pt complexes, which are situated close to each other, efficiently catalyze H2‐evolution reactions in aqueous media in the presence of a sacrificial electron donor (EDTA) under visible‐light irradiation. This study also investigates the effect of nanoconfinement on anchored guest complexes by considering the differences between the pore dimensions and structures of mesoporous‐silica materials.
Alloyed (ZnS)x(CuInS2)1−x Semiconductor Nanorods: Synthesis, Bandgap Tuning and Photocatalytic Properties
Authors: Ye Chen , Regulacio Michelle D. , Lim Suo Hon , Xu Qing‐Hua , Han Ming‐Yong 
Published: August 2012

AbstractRod‐like nanocrystals of the semiconductor alloy (ZnS)x(CuInS2)1−x (ZCIS) have been colloidally prepared by using a one‐pot non‐injection‐based synthetic strategy. The ZCIS nanorods crystallize in the hexagonal wurtzite structure and display preferential growth in the direction of the c axis. The bandgap of these quarternary alloyed nanorods can be conveniently tuned by varying the ratio of ZnS to CuInS2. A non‐linear relationship between the bandgap and the alloy composition is observed. The ZCIS nanorods are found to exhibit promising photocatalytic behaviour in visible‐light‐driven degradation of Rhodamine B.
ChemInform Abstract: Crystal Structure Analysis of Tungsten Bronzes β‐SrTa2O6 and β′‐SrTa2O6 by Synchrotron X‐Ray and Neutron Powder Diffraction.
Authors: Lee Eunhye , Park Cheol‐Hee , Shoemaker Daniel P. , Avdeev Maxim , Kim Young‐Il 
Published: August 2012

Abstractβ′‐SrTa2O6 crystallizes in the space group P4/mbm with Z = 5.
ChemInform Abstract: Controlling the Activator Site to Tune Europium Valence in Oxyfluoride Phosphors.
Authors: Huang Kuan‐Wei , Chen Wei‐Ting , Chu Cheng‐I , Hu Shu‐Fen , Sheu Hwo‐Shuenn , Cheng Bing‐Ming , Chen Jin‐Ming , Liu Ru‐Shi 
Published: August 2012

AbstractThe valence state of Eu in the new phosphor Ca12Al14O32F2:Eu3+ is tuned by replacing Al3+—F‐ by the dopant Si4+—O2‐.
ChemInform Abstract: NaCu(Ta1‐yNby)4O11 Solid Solution: A Tunable Band Gap Spanning the Visible‐Light Wavelengths.
Authors: Palasyuk Olena , Maggard Paul A. 
Published: August 2012

AbstractThe new title solid solution (0 ≤ y ≤ 0.7) is synthesized by solid state reaction of stoichiometric mixtures of Cu2O, Na2O, Nb2O5, and Ta2O5 (silica tubes, 950 °C, 4 d).
ChemInform Abstract: Hydrothermal Synthesis of Three‐Dimensional Open‐Framework Beryllium Phosphites with 3,4‐Connected Networks.
Authors: Luo Daibing , Luo Xiuchao , Kang Maoping , Lin Zhien 
Published: August 2012

AbstractThe new compounds (III) and (IV) crystallize in the monoclinic space group P21/c with Z = 4 and Z = 8, resp.
ChemInform Abstract: Tetrabutylammonium Cation in a Homoleptic Environment of Borohydride Ligands: [(n‐Bu)4N][BH4] and [(n‐Bu)4N][Y(BH4)4].
Authors: Jaron T. , Wegner W. , Cyranski M. K. , Dobrzycki L. , Grochala W. 
Published: August 2012

AbstractThe new compound Bu4N[Y(BH4)4] (I) is synthesized in the absence of any solvent by milling of a 1:1 mixture of Bu4N(BH4) (II) and Y(BH4)3 (vibrational mill).
ChemInform Abstract: Ionic Crystals Based on Keggin Anion and Mixed‐Valent Diruthenium Tetraacetate: [Ru2(CH3COO)4(H2O)2] 2[HnXW12O40]· [Ru2(CH3COO)4(H2O)Cl] ·12H2O (X: B, Si, Ge).
Authors: Liu Xuemei , Liu Bin , Xue Ganglin 
Published: August 2012

AbstractCompounds (III) and (Vb) crystallize isostructurally in the tetragonal space group P4/n with Z = 2 (single crystal XRD).
ChemInform Abstract: Development of the First Menthane‐Based Chiral Bis(π‐allylpalladium) Catalysis: Asymmetric Allylation of Imines.
Authors: Fernandes Rodney A. , Chaudhari Dipali A. 
Published: August 2012

AbstractAromatic, heteroaromatic, and aliphatic imines are allylated by allylstannane (III) under neutral conditions in the presence of (+)‐menthol‐derived dipalladium complex (I) to give homoallylamines with up to 78% enantioselectivity.
ChemInform Abstract: VCl3 Catalyzed Imine‐Based Multicomponent Reactions for the Facile Access of Functionalized Tetrahydropyridines and β‐Amino Carbonyls.
Authors: Pal Suman , Choudhury Lokman Hakim , Parvin Tasneem 
Published: August 2012

AbstractDepending on the substrate ratios, the same conditions can used for the preparation of either pyridine structures such as (IV) and (VII) or various amino ketones of type (XI).
ChemInform Abstract: 1,2,3‐Triazole: Unique Ligand in Promoting Iron‐Catalyzed Propargyl Alcohol Dehydration.
Authors: Yan Wuming , Ye Xiaohan , Akhmedov Novruz G. , Petersen Jeffrey L. , Shi Xiaodong 
Published: August 2012

AbstractThe process can be applied to a broad spectrum of substrates bearing a hydroxylated quaternary carbon center.
ChemInform Abstract: Simple Synthesis of β‐Trifluoromethylstyrenes Using (E)‐Trimethyl‐(3,3,3‐trifluoroprop‐1‐enyl)silane.
Authors: Omote Masaaki , Tanaka Miyuu , Ikeda Akari , Nomura Shiho , Tarui Atsushi , Sato Kazuyuki , Ando Akira 
Published: August 2012

AbstractStarting from commercially available materials, a gram‐scale preparation of the key compound (II) is described in three steps with an overall yield of 74%.
ChemInform Abstract: One‐Pot Synthesis of Aryl Oxime Analogues from Methyl Arenes Using NBS and Hydroxyl Amine Hydrochloride.
Authors: Chandrappa S. , Umashankara M. , Vinaya K. , Kumar C. S. Ananda , Rangappa K. S. 
Published: August 2012

AbstractThe reaction is advantageous with regard to functional group tolerance, high yield, and simple experimental procedure.
ChemInform Abstract: Direct and Selective Benzylic Oxidation of Alkylarenes via C—H Abstraction Using Alkali Metal Bromides.
Authors: Moriyama Katsuhiko , Takemura Misato , Togo Hideo 
Published: August 2012

AbstractA wide scope of carbonyl compounds is generated by thermal oxidation and photooxidation by visible light or natural sunlight, depending on the substituents of the alkylarenes.
ChemInform Abstract: Efficient Recyclable CuI‐Nanoparticle‐Catalyzed S‐Arylation of Thiols with Aryl Halides on Water under Mild Conditions.
Authors: Xu Hua‐Jian , Liang Yu‐Feng , Zhou Xin‐Feng , Feng Yi‐Si 
Published: August 2012

AbstractThe title procedure avoids the undesired formation of disulfides.
ChemInform Abstract: Triple Condensation of Aryl Methyl Ketones Catalyzed by Amine and Trifluoroacetic Acid: Straightforward Access to 1,3,5‐Triarylbenzenes under Mild Conditions.
Authors: Zhang Shao‐Liang , Xue Zhao‐Feng , Gao Ya‐Ru , Mao Shuai , Wang Yong‐Qiang 
Published: August 2012

AbstractThe process opens a rapid synthesis of hexabenzocoronene (V).
ChemInform Abstract: Ionic‐Liquid‐Supported 1,5‐7‐Triazabicyclo[4.4.0]dec‐5‐ene — An Efficient and Recyclable Organocatalyst for Michael Addition to α,β‐Unsaturated Ketones.
Authors: Muthyala Manoj Kumar , Chhikara Bhupender S. , Parang Keykavous , Kumar Anil 
Published: August 2012

AbstractTitle ionic liquid‐supported TBD efficiently catalyzes the Michael addition of malononitrile (II) as well as thiophenol (IV) towards chalcones (I) under mild conditions (neat, room temperature).
ChemInform Abstract: Synthesis and Optoelectronic Properties of Hexahydroxylated 10‐O‐R‐Substituted Anthracenes via a New Modification of the Friedel—Crafts Reaction Using O‐Protected ortho‐Acetal Diarylmethanols.
Authors: Bodzioch Agnieszka , Marciniak Bernard , Rozycka‐Sokolowska Ewa , Jeszka Jeremiasz K. , Uznanski Pawel , Kania Sylwester , Kulinski Janusz , Balczewski Piotr 
Published: August 2012

AbstractDiarylmethyl ethers (I) bearing an ortho‐acetal group at one arene ring undergo the cyclization under much milder reaction conditions compared to reported similar cyclization methods.
ChemInform Abstract: Unexpected Base‐Promoted Synthesis of Tetrasubstituted Furans via Palladium‐Catalyzed Oxidation and Cyclization of Carbon—Carbon Triple Bond with Molecular Oxygen.
Authors: Wang Lianyue , Li Jun , Lv Ying , Zhao Gongda , Gao Shuang 
Published: August 2012

AbstractThe attempt to prepare diketones under the conditions shown gives only trace amounts of the desired product and a polysubstituted furan is formed instead.