bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accommodation available: China, Western powers and the operation of structural power in theUNSecurity Council
Authors: Gowan Richard 
Published: May 2024

AbstractThis article focuses on the way that China and the main Western states on the United Nations Security Council have pursued “mutual accommodation” as China's geopolitical weight has grown in recent years. China still only rarely uses its veto and typically avoids taking responsibility for drafting Council products. Western powers are nonetheless careful to acknowledge and accommodate China's interests wherever possible, through tactics like watering down proposed Council products and avoiding confrontational meetings. China reciprocates by not blocking Western actions outright, but can take advantage of Western caution to gain leverage in the Council. In light of their toxic relationship with Russia, the United States, the United Kingdom and France see avoiding a strategic breakdown in their relations with China as in their strategic interests. Overall, the article highlights how the structural power inherent in the mutual constitution of the capacities and identities of the permanent members of the Security Council influences the social relations of the members and helps them to reach a compromise over many challenging issues The article illustrates this argument with detailed examples from Council diplomacy over Myanmar and Ukraine.
Comprehensive power shifts in the making: China's policy transfer partnerships with the United Nations
Authors: Haug Sebastian , Waisbich Laura Trajber 
Published: May 2024

AbstractChina and the United Nations (UN) have set up a growing number of partnerships to transfer Chinese domestic development policies across the South. By examining these partnerships through a power shift lens, we suggest that UN‐endorsed policy transfer processes can function as a window into shifting international cooperation dynamics. The paper first provides an overview of the evolution and key characteristics of China–UN policy transfer partnerships, focusing on China's trajectory as a provider of policy solutions. It then analyses the extent to which the evolving partnership landscape contributes to and reflects shifts in China's compulsory, institutional, structural and productive power. Overall, we argue that policy transfer partnerships contribute to comprehensive power shifts in the making: while empirical data point to China's often (still) limited and evolving ability to influence the actions of others, our findings provide evidence for increasing levels of Chinese influence in and through policy transfer partnerships across all power types.
Power shifts in international organisations: China at the United Nations
Authors: Haug Sebastian , Foot Rosemary , Baumann Max‐Otto 
Published: May 2024

AbstractThe People's Republic of China is central to current debates about power shifts in international organisations, but a systematic and comprehensive assessment of China‐related shifts has been missing. As Special Issue introduction, this article contributes to addressing this gap and examines whether, how and to what extent China‐related power shifts have unfolded at the United Nations (UN) over the last two decades or so. We define power shifts as changes in the ability of actors to shape others' capacities to act and outline a framework that builds on Barnett and Duvall's four power types of compulsory, institutional, structural and productive power. Drawing from Special Issue contributions, our analysis covers empirical insights from the UN's three main pillars – peace and security, development and human rights – and paints an uneven picture. Despite continuing Western dominance, China is mobilising more compulsory power means than two decades ago. Chinese attempts to enact institutional power have also increased but mostly unfold in multilateral niches and remain cautious. While China's structural power position has expanded, China‐related effects in productive power have so far remained limited and scattered. We conclude with a combined assessment of changes across power types and discuss research and policy implications.
Cellular mechanism underlying leptin‐induced anion secretion of rat epididymal epithelial cells
Authors: Gao Dong‐Dong , Liu Guo‐Qing , Chen Yi‐Lin , Ding Nan , Zhong Jia‐Hui , Liang Guang‐Nan , Deng Wei‐Ji , Li Pei‐Lun , Su Jia‐Rui , Wang Ming , Huang Jun‐Hao , Hu Min 
Published: May 2024

AbstractBackgroundA large number of studies have shown that leptin plays an important role in the regulation of fertility via the hypothalamus‐pituitary‐gonad axis. However, its peripheral function in epididymis was still elusive.ObjectiveThe purpose of this study was to determine the pro‐secretion effect of leptin on the rat epididymal epithelium.Materials and methodsIn the present study, real‐time quantitative polymerase chain reaction, western blot, and immunohistochemical analysis were employed to detect the expression pattern of leptin receptors in rat epididymis. The pro‐secretion effect of leptin on epididymal epithelial cells was measured by short‐circuit current, and the prostaglandin E2 and cyclic adenosine monophosphate level was evaluated by enzyme‐linked immunosorbent assay.ResultsWe verified that the leptin receptor was located on the epididymal epithelium, with a relatively high expression level in corpus and cauda epididymis. Ussing chamber experiments showed that leptin stimulated a significant rise of the short‐circuit current in rat epididymal epithelial cells, which could be abolished by the specific leptin receptor antagonist peptide Allo‐aca, or by removing the ambient Cl− and HCO3−. Furthermore, the leptin‐stimulated short‐circuit current response could be abrogated by blocking the apical cystic fibrosis transmembrane regulator or the basolateral Na+‐K+‐2Cl− cotransporter. Our pharmacological experiments manifested that interfering with the prostaglandin H synthase‐2‐prostaglandin E2‐EP2/EP4‐adenylate cyclase pathways could significantly blunt the cystic fibrosis transmembrane regulator‐mediated anion secretion induced by leptin. The enzyme‐linked immunosorbent assay demonstrated that leptin could induce a substantial increase in prostaglandin E2 release and cyclic adenosine monophosphate synthesis of primary cultured rat cauda epididymal epithelial cells. Our data also suggested that JAK2, ERK, and PI3K‐dependent phosphorylation may be involved in the activation of prostaglandin H synthase‐2 and the subsequent prostaglandin E2 production.ConclusionsThe present study demonstrated the pro‐secretion function of leptin in rat epididymal epithelium via the activation of cystic fibrosis transmembrane regulator and Na+‐K+‐2Cl− cotransporter, which was dependent on the paracrine/autocrine prostaglandin E2 stimulated EP2/EP4‐adenylate cyclase pathways, and thus contributed to the formation of an appropriate microenvironment essential for sperm maturation.
Advancement of 3D printing technology for the development of a training model in US‐guided vesicoamniotic shunting for early LUTO therapy
Authors: Recker Florian , Schremmer Tobias , Berg Christoph , Schäfer Valentin Sebastian , Strizek Brigitte , Jimenez‐Cruz Jorge 
Published: May 2024

AbstractIntroductionPrenatal lower urinary tract obstruction (LUTO) is a rare and challenging condition with potential severe morbidity and mortality. Prenatal shunting methods, specifically vesicoamniotic shunting (VAS) and fetal cystoscopy, aim to manage this condition. However, comprehensive education and training are hindered by the rarity of LUTO. To address this gap, we present a low‐cost 3D‐printed ultrasound training model for VAS in LUTO fetuses. The aim of the study was to evaluate ultrasound and haptic fidelity of the model.Material and MethodsUltrasound images of three LUTO fetuses at 12–14 weeks were utilized to create detailed 3D‐printed models. Fusion360TM software generated stereo‐lithography files, and the Formlabs Form3® printer, using Flexible 80A resin, produced the models. A simulation box mimicking uterine conditions and fetal anatomy was developed for testing. Ultrasound assessments determined model accuracy, and expert evaluations gauged fidelity for VAS placement.ResultsThe 3D‐printed model accurately replicated LUTO fetal anatomy, demonstrating structural integrity and realistic sonographic and haptic feedback during 20 punctures. Macroscopic visualization confirmed the model's durability and authenticity.DiscussionThis innovative 3D‐printed model addresses the scarcity of LUTO cases and the lack of realistic training tools. Simulation models enhance skills, providing a controlled learning environment that bridges theoretical knowledge and clinical application, potentially improving patient outcomes.ConclusionsThe 3D‐printed training model for VAS in LUTO represents a significant advancement in surgical education, offering realistic anatomical simulation and tactile feedback. Future studies should assess its effectiveness in enhancing surgical skills and impacting patient outcomes in clinical practice.
Resveratrol‐coated chitosan mats promote angiogenesis for enhanced wound healing in animal model
Authors: Moghaddam Asma , Nejaddehbashi Fereshteh , Orazizadeh Mahmoud 
Published: May 2024

AbstractBackgroundGrowing incidences of chronic wounds recommend the development of optimal therapeutic wound dressings. Electrospun nanofibers have been considered to show potential wound healing properties when accompanied by other wound dressing materials. This study aimed to explore the potential role of Chitosan (CS) nanofibrous mats coated with resveratrol (RS) as an antioxidant and pro‐angiogenic agent in rat models of skin wound healing.MethodsElectrospun chitosan/polyethylene oxide (PEO) nanofibers were prepared using electrospinning technology and coated by 0.05 and 0.1 mg.ml resveratrol named as (CS/RS 0.05) and (CS/RS 0.1), respectively. The scaffolds were characterized physiochemically such as in vitro release study, TGA, FTIR spectroscopy analysis, biodegradability, and human dermal fibroblast seeding assay. The scaffold was subsequently used in vivo as a skin substitute on a rat skin wound model.ResultsIn vitro tests revealed that all scaffolds promoted cell adhesion and proliferation. However, more cell viability was observed in CS/RS 0.1 scaffold. The biocompatibility of the scaffolds was validated by MTT assay, and the results did not show any toxic effects on human dermal fibroblasts. It was observed that RS‐coated scaffolds had the ability to release RS in a controlled manner. In in vivo tests CS/RS 0.1 scaffold had the greatest impact on the healing process by improving the neodermis formation and modulated inflammation in wound granulation tissue. Histological analysis revealed enhanced vascular endothelial growth factor expression, epithelialization and increased depth of wound granulation tissue.ConclusionsThe RS‐coated CS/PEO nanofibrous scaffold accelerates wound healing and may be useful as a dressing for cell transfer and clinical skin regeneration.
Managing dissatisfaction after multifocal intraocular lens implantation through lens exchange using monofocal or alternative multifocal IOLs
Authors: Al‐Shymali Olena , Cantó‐Cerdán Mario , Alió del Barrio Jorge L. , McAlinden Colm , Yebana Pilar , Alio Jorge L. 
Published: May 2024

AbstractPurposeTo manage patient dissatisfaction following multifocal intraocular lens (MF‐IOL) implantation by IOL exchange with either a monofocal or an alternative MF‐IOL, and to compare outcomes in these two groups.MethodsMF‐IOL exchange was performed in 32 patients (64 eyes) with neuroadaptation failure. The MF‐to‐MF group involved patients who had a MF‐IOL exchanged with another MF‐IOL of a different optical profile and the MF‐to‐MO group involved patients who had a MF‐IOL exchanged to a monofocal IOL. Visual outcomes and complications were analysed. The Quality of Vision (QoV) questionnaire, Visual Function Index (VF‐14) and its Rasch‐revised version (VF‐8R) were also used to assess outcomes.ResultsThere were no significant differences (p > 0.05) in the QoV scores between the two groups, both preoperatively and postoperatively. Preoperatively, there were no significant differences in VF‐14 scores between both groups (p > 0.05). Postoperatively, there were statistically significant differences in VF‐14 (total score, intermediate vision and near vision) in favour of the MF‐to‐MF group (p < 0.05). The postoperative VF‐8R score in the MF‐to‐MF group was significantly better than the MF‐to‐MO group (p ≤ 0.001). Uncorrected and corrected near as well as corrected distance visual acuities were significantly better (p < 0.05) in the MF‐to‐MF group compared to the MF‐to‐MO group at 3 months.ConclusionPatient dissatisfaction and neuroadaptation failure following MF‐IOL implantation can be managed by an IOL exchange with an alternative optical design of MF‐IOL or a monofocal IOL. Although, in the current study, the MF‐to‐MF group showed some better postoperative results, both options are feasible solutions.
Editorial: Revisit the causes and long‐term outcomes in cirrhosis patients
Authors: Yeh Ming‐Lun , Huang Jee‐Fu 
Published: May 2024

LINKED CONTENTThis article is linked to Tran et al papers. To view these articles, visit https://doi.org/10.1111/apt.18024 and https://doi.org/10.1111/apt.18065.
Letter: Early real‐world evidence from the United Arab Emirates of the persistence, effectiveness and safety of risankizumab for the treatment of Crohn's disease—Authors' reply
Authors: Yiu Tsz Hong , Ko Yanna , Pudipeddi Aviv , Natale Patrizia , Leong Rupert W. 
Published: May 2024

LINKED CONTENTThis article is linked to Yiu et al papers. To view these articles, visit https://doi.org/10.1111/apt.18006 and https://doi.org/10.1111/apt.18049
NIPT for adult‐onset conditions: Australian NIPT users' views
Authors: Marks India R. , Devolder Katrien , Bowman‐Smart Hilary , Johnston Molly , Mills Catherine 
Published: May 2024

AbstractNoninvasive prenatal testing (NIPT) has become widely available in recent years. While initially used to screen for trisomies 21, 18, and 13, the test has expanded to include a range of other conditions and will likely expand further. This paper addresses the ethical issues that arise from one particularly controversial potential use of NIPT: screening for adult‐onset conditions (AOCs). We report data from our quantitative survey of Australian NIPT users' views on the ethical issues raised by NIPT for AOCs. The survey ascertained support for NIPT for several traits and conditions including AOCs. Participants were then asked about their level of concern around implications of screening for AOCs for the future child and parent(s). Descriptive and comparative data analyses were conducted. In total, 109 respondents were included in data analysis. The majority of respondents expressed support for NIPT screening for preventable (70.9%) and nonpreventable AOCs (80.8%). Most respondents indicated concern around potential harmful impacts associated with NIPT for AOCs, including the psychological impact on the future child and on the parent(s). Despite this, the majority of participants thought that continuation of a pregnancy known to be predisposed to an AOC is ethically acceptable. The implications of these data are critically discussed and used to inform the normative claim that prospective parents should be given access to NIPT for AOCs. The study contributes to a body of research debating the ethical acceptability and regulation of various applications of NIPT as screening panels expand.
Protecting against misinformation: Evaluating the effectiveness of three techniques to reduce memory conformity
Authors: Kękuś Magdalena , Dziubańska Regina , Michalak Kacper , Polczyk Romuald , Szpitalak Malwina , Barzykowski Krystian 
Published: May 2024

AbstractThe memory conformity effect occurs when people witness a given incident (e.g. a crime) then talk to each other about it, and the statement of one person affects the memory account of the other person with respect to this incident. The aim of this article is to improve the quality of witness testimony by verifying the effectiveness of three methods that aim to reduce memory conformity effect: (1) an extended warning against misinformation; (2) a method based on information about memory functioning and its fallibility and (3) a method consisting in motivating participants to resist influence and demonstrating their individual vulnerability to it. In the presented experiment, the innovative MORI technique was used to study the memory conformity effect. This technique allows a pair of participants to sit beside each other, look at the same screen and see a different version of the same criminal event. In the next stages, the subjects are asked to answer a series of questions about different details, thereby introducing mutual misinformation; then, the participants perform an individual memory test. In the experimental conditions, this test was preceded by one of the three tested methods in each group, with the aim of determining their effectiveness in reducing memory conformity. It turns out that the implementation of an extended warning against misinformation eliminated the memory conformity effect, while the application of two other methods led to a reduction (but not complete elimination) of the studied phenomenon.
Pathologic TDP‐43 downregulates myelin gene expression in the monkey brain
Authors: Zhu Longhong , Bai Dazhang , Wang Xiang , Ou Kaili , Li Bang , Jia Qingqing , Tan Zhiqiang , Liang Jiahui , He Dajian , Yan Sen , Wang Lu , Li Shihua , Li Xiao‐Jiang , Yin Peng 
Published: May 2024

AbstractGrowing evidence indicates that non‐neuronal oligodendrocyte plays an important role in Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. In patient's brain, the impaired myelin structure is a pathological feature with the observation of TDP‐43 in cytoplasm of oligodendrocyte. However, the mechanism underlying the gain of function by TDP‐43 in oligodendrocytes, which are vital for the axonal integrity, remains unclear. Recently, we found that the primate‐specific cleavage of truncated TDP‐43 fragments occurred in cytoplasm of monkey neural cells. This finding opened up the avenue to investigate the myelin integrity affected by pathogenic TDP‐43 in oligodendrocytes. In current study, we demonstrated that the truncated TDP‐35 in oligodendrocytes specifically, could lead to the dysfunctional demyelination in corpus callosum of monkey. As a consequence of the interaction of myelin regulatory factor with the accumulated TDP‐35 in cytoplasm, the downstream myelin‐associated genes expression was downregulated at the transcriptional level. Our study aims to investigate the potential effect on myelin structure injury, affected by the truncated TDP‐43 in oligodendrocyte, which provided the additional clues on the gain of function during the progressive pathogenesis and symptoms in TDP‐43 related diseases.
Trends in the nonmedical misuse of benzodiazepines and Z‐hypnotics among school‐aged adolescents (2016–2021): gender differences and related factors
Authors: Carrasco‐Garrido Pilar , Hernández‐Barrera Valentín , Jiménez‐Trujillo Isabel , Lima Florencio Lidiane , Gallardo Pino Carmen , Yeamans Spencer , Palacios‐Ceña Domingo 
Published: May 2024

BackgroundThe misuse of psychotropic medication has increased during the past decade, especially among adolescents. The aim of our study was to describe the prevalence and patterns of the nonmedical use of benzodiazepines (BDZ) and Z‐hypnotics among school‐aged adolescents through the lens of sex. In addition, we sought to analyze the temporal evolution of the nonmedical use of these drugs during the period 2016–2021.MethodsThe temporal evolution of the nonmedical use of these drugs was analyzed based on survey data collected in 2016, 2018 and 2021, which includes the first years of the COVID‐19 pandemic. To assess the possible effect of the COVID‐19 pandemic, the year at survey was conducted was introduced as a categorical variable. We used data from the Spanish State Survey on Drug Use in Secondary Education, which covers drug use among students aged 14–18 years. Using multivariate logistic regression models, we estimated the independent effect of different variables (sociodemographic data, use of other psychoactive substances, risk perception and availability) on the nonmedical use of BDZ and Z‐hypnotics.ResultsIn total, survey data from 95,700 adolescents were included in our analysis. The nonmedical use of BDZ and Z‐hypnotics increased among adolescents during the study period. The adjusted odds ratio (AOR) from 2016 to 2018 was 1.11 (95% CI 0.94–1.31) and from 2018 to 2021 the AOR was 1.26 (95% CI 1.08–1.46), using 2016 and 2018, respectively, as reference years. The nonmedical use of BDZ and Z‐hypnotics was more likely in adolescent girls than boys (AOR = 2.11). The nonmedical use of prescription opioids (AOR = 3.44), novel psychoactive substances and other illicit psychoactive drugs (AOR = 4.10) were risk factors for the nonmedical use of BDZ and Z‐hypnotics in both sexes. Use of cannabis (AOR = 1.38) was a predictor of nonmedical use in female adolescents only.ConclusionsThis study shows that the trend of the nonmedical use of BDZ and Z‐hypnotics among school‐aged adolescents in Spain increased between 2016 and 2021. Among adolescents aged 14 to 18, the probability of nonmedical use of these psychoactive substances was twice as high for female adolescents as for male adolescents.
Differential effect of social mobility on tooth loss by race in adulthood: 1982 Pelotas Birth Cohort Study
Authors: Karam Sarah Arangurem , Schuch Helena Silveira , Demarco Flávio Fernando , Horta Bernardo L. , Borrell Luisa N. , Celeste Roger Keller , Correa Marcos Britto 
Published: May 2024

AbstractObjectivesTo examine the association between social mobility and tooth loss in adults from the 1982 Pelotas Birth Cohort Study and whether race modifies this association.MethodsThe Oral Health Study used data from 541 individuals who were followed up to 31 years of age. Social mobility, composed of the participants' socioeconomic position (SEP) at birth and at age 30, was categorized as never poor, upwardly mobile, downwardly mobile and always poor. The outcome was the prevalence of at least one tooth lost due to dental caries when the participants were examined at 31 years of age. The effect modifier was race (Black/Brown versus white people). Log‐binomial regression models were used to estimate crude and sex‐adjusted prevalence ratios (PR) and to determine whether the association varied with race. Statistical interactions were tested using an additive scale.ResultsThe prevalence of any tooth loss was 50.8% (n = 274). In social mobility groups, the prevalence of at least one tooth lost in the never‐poor group was about 31% points higher for Black/Brown (68.2%) than for white people (37.4%). Antagonistic findings were found for the interaction between race and social mobility (Sinergy Index = 0.48; 95% CI 0.24, 0.99; and relative excess of risk due to the interaction = −1.38; 95% CI −2.34, −0.42), suggesting that the observed joint effect of race and social mobility on tooth loss was lower than the expected sum of these factors. The estimates for Black/Brown people were smaller for those who were always poor during their lives, relative to their white counterparts.ConclusionsThe findings suggest a higher prevalence of at least one tooth lost among people in the downward mobile SEP group and Black/Brown people. Greater racial inequity was found among Black/Brown people who had never experienced episodes of poverty, with Black/Brown people having a greater prevalence of at least one tooth lost than their white counterparts.