bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interfacial Electron Transfer Dynamics of Two Newly Synthesized Catecholate Bound RuII Polypyridyl‐Based Sensitizers on TiO2 Nanoparticle Surface – A Femtosecond Pump Probe Spectroscopic Study
Authors: Banerjee Tanmay , Rawalekar Sachin , Das Amitava , Ghosh Hirendra N. 
Published: August 2011

AbstractTwo new catecholate‐bound RuII–polypyridine based sensitizers, (2,2′‐bipyridine){ethyl 3‐(4‐hydroxyphenyl)‐2‐[(4′‐methyl‐2,2′‐bipyridinyl‐4‐carbonyl)amino]propionate}{4‐[2‐(4′‐methyl‐2,2′‐bipyridinyl‐4‐yl)vinyl]benzene‐1,2‐diol)}ruthenium(II) hexafluorophosphate (5) and [(2,2′‐bipyridine)‐(4‐2,2′‐bipyridinyl‐4‐yl‐phenol)‐(4‐{2‐(4′‐methyl‐2,2′‐bipyridinyl‐4‐yl)vinyl}benzene‐1,2‐diol)]ruthenium(II) hexafluorophosphate (6) with secondary electron‐donating groups (tyrosine and phenol, respectively) were synthesized and characterized. Steady‐state optical absorption and emission studies confirm strong coupling between the sensitizers and TiO2 nanoparticles. Femtosecond visible transient absorption spectroscopy has been employed to study interfacial electron transfer (IET) dynamics in the dye–nanoparticle systems to explore the influence of the secondary electron‐donating groups on IET dynamics. Electron injection into the conduction band of nanoparticulate TiO2 has been confirmed by detection of the conduction band electrons in TiO2 ([e–]TiO2CB) and radical cation of the adsorbed dye (D·+) in real time monitored by transient absorption spectroscopy. A single exponential and pulse‐width limited (< 100 fs) electron injection has been observed. Back electron transfer (BET) dynamics have been studied by monitoring the decay kinetics of the injected electron in the conduction band of TiO2 and by the recovery of the ground state bleach. BET dynamics in dye–TiO2 systems for complexes 5 and 6 have been compared with those of [bis(2,2′‐bpy)‐(4‐{2‐(4′‐methyl‐2,2′‐bipyridinyl‐4‐yl)vinyl}benzene‐1,2‐diol)]ruthenium(II) hexafluorophosphate (7), which does not have a secondary electron‐donating group.
A novel process for extraction of tea oil from Camellia oleifera seed kernels by combination of microwave puffing and aqueous enzymatic oil extraction
Authors: Zhang Wei‐guo , Zhang De‐cheng , Chen Xiao‐yuan 
Published: August 2011

AbstractThe objective of this study was to extract the oil from Camellia oleifera seed kernels by aqueous enzymatic oil extraction (AEOE). We describe a novel process for extraction of tea oil preceded by tea saponin extraction from C. oleifera seed kernels. The extraction efficiency obtained with microwave‐assisted extraction (MAE) is very high, which the recovery yield is up to 83% in 30 s and the saponins in camellia seed kernels can be completely removed by the second MAE. Moreover, an important step in the process development has been the pretreatment by microwave puffing of camellia seed kernel residues followed by AEOE increased oil extraction yield from 53% to 95%, which will is comparable to hexane oil extraction yields from plant materials.
Redox Properties and Cytotoxicity of Synthetic Isomeric Mitochondriotropic Derivatives of the Natural Polyphenol Quercetin
Authors: Mattarei Andrea , Sassi Nicola , Durante Christian , Biasutto Lucia , Sandonà Giancarlo , Marotta Ester , Garbisa Spiridione , Gennaro Armando , Paradisi Cristina , Zoratti Mario 
Published: August 2011

AbstractMitochondria‐targeted redox‐active polyphenol derivatives are being developed to affect redox processes in the organelles and as tools either to protect cells from oxidative damage or to precipitate their death. The properties of such compounds may be altered by substituents introduced to enhance mitochondrial delivery. Accordingly, we have characterized the redox behaviour of two isomeric mitochondriotropic quercetin‐based compounds, 3O‐ and 7O‐[4‐triphenylphosphonio)butyl]quercetin iodide. In both cyclic voltammetric determinations of the oxidation potential and in 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging assays, the 7‐substituted isomer behaved much like quercetin itself, whereas the 3‐substituted isomer was less reactive. Low μM concentrations of either compound increased superoxide radical anion formation in cultured cells; both compounds were also cytotoxic. The 7‐substituted derivative proved to be more active in both types of assays, thus emerging as the isomer of choice for further bioactivity studies and in efforts to understand the link between redox properties, pro‐oxidant behaviour and cytotoxicity.
First Synthesis of Medium‐Sized Ring Allenyl Lactams
Authors: Perscheid Moritz , Schollmeyer Dieter , Nubbemeyer Udo 
Published: August 2011

AbstractMedium‐sized lactams bearing an axially chiral allene unit have been synthesized by using an aza‐ketene Claisen rearrangement. Starting from 2‐alkynylpiperidines or 2‐alkynylazepines, ring enlargement enabled the highly diastereoselective formation of 10‐ or 11‐membered lactams with a 4,5‐allene subunit. X‐ray analysis of the allenylacezinone showed the presence of a strained cumulated olefin system with a defined arrangement of the functional groups. The cyclic allenes were found to be stable upon heating up to 50 °C.
One‐Pot Synthesis of Fused Benzo[c]carbazoles by Photochemical Intramolecular Annulation of 3‐Acyl‐2‐haloindoles with Tethered Styrenes
Authors: Lu Shen‐Ci , Wei Shi‐Chao , Wang Wei‐Xia , Zhang Wei , Tu Zhi‐Feng 
Published: August 2011

AbstractAn efficient procedure for the synthesis of fused benzo[c]carbazoles has been achieved in moderate to high yields by the one‐pot photochemical annulation of 3‐acyl‐2‐haloindoles with tethered styrenes by photoinduced electron‐transfer coupling, electrocyclic reactions, and deacylative aromatization in the presence of pyridine. Fused furo[2,3‐c]carbazoles were also synthesized under the same conditions. 5,6‐Dihydrobenzo[c]pyrrolo[1,2,3‐lm]carbazoles were oxidized by DDQ to afford aromatic benzo[c]pyrrolo[1,2,3‐lm]carbazole products in moderate to high yields.
Barcoding ofGiardia duodenalisisolates and derived lines from an established cryobank by a mutation scanning‐based approach
Authors: Nolan Matthew J. , Jex Aaron R. , Upcroft Jacqui A. , Upcroft Peter , Gasser Robin B. 
Published: August 2011

AbstractWe barcoded 25 in vitro isolates (representing 92 samples) ofGiardia duodenalisfrom humans and other animals, which have been assembled by the Upcroft team at the Queensland Institute of Medical Research over a period of almost three decades. We used mutation scanning‐coupled sequencing of loci in the triosephosphate isomerase, glutamate dehydrogenase and β‐giardin genes, combined with phylogenetic analysis, to genetically characterise them. Specifically, the isolates (n=14) ofG.duodenalisfrom humans from Australia (AD113; BRIS/83/HEPU/106; BRIS/87/HEPU/713; BRIS/89/HEPU/1003; BRIS/92/HEPU/1541; BRIS/92/HEPU/1590; BRIS/92/HEPU/2443; BRIS/93/HEPU/1706), Malaysia (KL/92/IMR/1106) and Afghanistan (WB), a cat from Australia (BAC2), a sheep from Canada (OAS1) and a sulphur‐crested cockatoo from Australia (BRIS/95/HEPU/2041) represented assemblage A (sub‐assemblage AI‐1, AI‐2 or AII‐2); isolates (n=10) from humans from Australia (BRIS/91/HEPU/1279; BRIS/92/HEPU/2342; BRIS/92/HEPU/2348; BRIS/93/HEPU/1638; BRIS/93/HEPU/1653; BRIS/93/HEPU/1705; BRIS/93/HEPU/1718; BRIS/93/HEPU/1727), Papua New Guinea (BRIS/92/HEPU/1487) and Canada (H7) represented assemblage B (sub‐assemblage BIV) and an isolate from cattle from Australia (BRIS/92/HEPU/1709) had a match to assemblage E. Isolate BRIS/90/HEPU/1229 from a human from Australia was shown to represent a mixed population of assemblages A and B. These barcoded isolates (including stocks and derived lines) now allow direct comparisons of experimental data among laboratories and represent a massive resource for transcriptomic, proteomic, metabolic and functional genomic studies using advanced molecular technologies. (Nucleotide sequences reported in this paper are available in the GenBank database under accession nos. JN204442–JN204461.)
Perlecan domain V modulates astrogliosis In vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release
Authors: Al‐Ahmad Abraham J. , Lee Boyeon , Saini Maxim , Bix Gregory J. 
Published: August 2011

AbstractAstrogliosis constitutes part of the central nervous system's physiological response to injury. Considered for decades to be a major challenge for brain repair, recent studies have highlighted it as a promoter of such repair mechanisms. Recently, our group demonstrated the ability of perlecan domain V (DV) to be a novel potential stroke therapy by its neuroprotective effects. However, the potential for DV to modulate astrogliosis has not been investigated. The aim of this study is to better understand the relevance of DV to astrogliosis using both in vitro and in vivo rodent models. Notably, under basal conditions, astrocytes express all three DV receptors described in the literature: integrin α2β1, α5β1, and α‐dystroglycan (αDG). DV promoted astrocyte cell adhesion, cell migration as well as astrocyte stellation. Moreover, DV induced nerve growth factor (NGF) secretion through a αDG‐ and ERK‐dependent pathway. In contrast, α2β1 or α5β1 mediated DV antiproliferative effects in astrocytes. NGF production after DV treatment acted as a strong anti‐proliferative agent. Another remarkable effect of DV was that it decreased several markers of astrogliosis such as glial fibrillary acidic protein (GFAP), neurocan and phosphacan both in vitro and in vivo, suggesting the role of DV as a potential modulator of postinjury during late astrogliosis, and eventually the onset of glial scarring. Taken together, our study demonstrates the ability of DV to modulate key events of astrogliosis by promoting early astrogliosis and inhibiting glial scar formation, suggesting an additional therapeutic benefit of DV for recovery from stroke. © 2011 Wiley‐Liss, Inc.
Translational regulation mechanisms of aquaporin‐4 supramolecular organization in astrocytes
Authors: Pisani Francesco , Rossi Andrea , Nicchia Grazia Paola , Svelto Maria , Frigeri Antonio 
Published: August 2011

AbstractThe two predominant isoforms of Aquaporin‐4 (AQP4), AQP4‐M23 and AQP4‐M1, assemble in the plasma membrane to form supramolecular structures called Orthogonal Array of Particles (OAPs) whose dimension is tightly associated to the M1/M23 ratio. Here, we explore translational regulation contribution to M1/M23 expression in primary cultures of rat astrocytes, and analyze the role of M1 mRNA 5′untranslated region (5′UTR) in this mechanism. Using isoform‐specific RNAi we found that in rat astrocytes primary cultures a large proportion of M23 protein derives from M1 mRNA translation. Furthermore, site‐specific mutagenesis of the 5′UTR sequence of AQP4‐M1 mRNA indicates that a multiple‐site leaky scanning mechanism, an out‐of‐frame upstream ORF (uORF), and a reinitiation mechanism are able to modulate the M1/M23 ratio and consequently, OAPs formation. These mechanisms are likely to be shared by different species, including human, and they can also be assumed to play a role in those pathophysiological situations where the organization of AQP4 in supramolecular structures (OAPs) is involved. Finally, we report that, when transfected in Hela cells, the longer rat AQP4 isoform, called Mz, which is not present in human impairs OAPs formation. © 2011 Wiley‐Liss, Inc.
Relationship between serum thyroglobulin and 18FDG‐PET/CT in 131I‐negative differentiated thyroid carcinomas
Authors: Giovanella Luca , Ceriani Luca , De Palma Diego , Suriano Sergio , Castellani Massimo , Verburg Frederik A. 
Published: August 2011

AbstractBackgroundThe purpose of this study was to assess the relationship between [18F]‐fluorodeoxyglucose (18FDG)‐positron emission tomography/CT (18FDG‐PET/CT) and serum thyroglobulin (Tg) in patients with recurrent differentiated thyroid carcinoma (DTC).MethodsForty‐two patients with recurrent DTC and negative Tg antibodies were included in the study. All patients underwent 131I therapy due to an increasing serum Tg with a corresponding negative 131I posttreatment whole body scan. The 18FDG‐PET/CT scans were then performed on all patients, serum Tg was measured concurrently, and respective results were compared.ResultsSensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and accuracy of the 18FDG‐PET/CT examination were 93%, 84%, 93%, 84%, and 90%, respectively. The sensitivity of 18FDG‐PET/CT significantly increased in patients with serum Tg levels ≥4.6 ng/mL (96%) in comparison with patients having lower levels (25%; p < .001). Nonetheless, 3 of 27 patients (11%) with a true‐positive 18FDG‐PET/CT still had a Tg <4.6 ng/mL.ConclusionAlthough 18FDG‐PET/CT scans are more likely to be positive with pretest Tg levels ≥4.6 ng/mL, 11% of patients with DTC with a lower serum Tg level will still have a positive scan. Our findings are in contrast with the American Thyroid Association (ATA) guidelines, which only recommend to perform 18FDG‐PET/CT in patients with Tg levels >10 ng/mL. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Cancer stem cells in head and neck squamous cell carcinoma: A review of current knowledge and future applications
Authors: Bhaijee Feriyl , Pepper Dominique J. , Pitman Karen T. , Bell Diana 
Published: August 2011

AbstractHead and neck squamous cell carcinoma (HNSCC) is a major cause of morbidity and mortality, and the alleviation thereof requires greater understanding of the pathobiologic behavior of HNSCC. Although the existence of cancer stem cells (CSCs) in most solid tumors has not been formally proven, application of the CSC concept has certainly enhanced understanding of HNSCC heterogeneity and progression. Recent data support the role of ALDH1+CD44+ CSC in HNSCC, since the implantation of a few ALDH1+CD44+ cells consistently gives rise to tumors that can be serially passaged in vivo. In addition to CSC biomarkers, recent explorations of CSC signaling pathways, gene expression, and localization in HNSCC carry significant clinical and therapeutic implications. Identification and characterization of CSC populations that regulate HNSCC growth, metastasis, and treatment resistance will facilitate development of novel diagnostic, therapeutic, and prognostic strategies. Furthermore, advances in multimodal imaging and nanotechnology, in conjunction with CSC models, may better elucidate the regulatory mechanisms that govern CSC biology in vivo, as well as develop platforms for targeted theragnostics. It is hoped that the promising applications of the CSC model in HNSCC will eventually alleviate the morbidity and mortality of this pervasive disease. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Treatment‐induced changes in vocal cord mobility and subsequent local recurrence after organ preservation therapy for laryngeal carcinoma
Authors: Lee Walter T. , Yoo David S. , Puscas Liana , Witsell David , M. Cohen Seth , R. Fisher Samuel , Scher Richard , Broadwater Gloria , Ready Neal , R. Brizel David , Esclamado Ramon M. 
Published: August 2011

AbstractBackgroundAs multidisciplinary cancer treatment evolves, strategies to identify patients needing early resection/salvage are necessary. Some have suggested that vocal cord function after organ‐preservation treatment may be an indicator.MethodsA retrospective review was performed of patients presenting with fixed or impaired vocal cord function at a tertiary center. Local recurrence rates were examined in patients with and without improved/normal mobilization after treatment.ResultsSixty‐nine patients met the inclusion criteria, with 35 patients having vocal cord fixation and 34 patients with impaired mobility. After treatment, 44 patients had normalization of vocal cord function, while 25 patients did not, with 2‐year local control rates of 70% and 77%, p = .23, respectively. No difference in local control was found between patients with normalized/improved cord function (n = 53) and those who remained the same/worsened (n = 16; p = .81).ConclusionTherapy‐induced changes in vocal cord mobility did not correlate with local recurrence. Other criteria are needed to identify patients most likely to benefit from early surgical resection/salvage after organ preservation. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Postoperative radiation therapy for small, low‐/intermediate‐grade parotid tumors with close and/or positive surgical margins
Authors: Richter Samuel M. , Friedmann Patricia , Mourad Waleed F. , Hu Kenneth S. , Persky Mark S. , Harrison Louis B. 
Published: August 2011

AbstractBackgroundPatients with small, low‐/intermediate‐risk parotid cancers, treated with surgery, and who have the single prognostic factor of close and/or positive margins, constitute an unusual subset. This study evaluates local control and morbidity associated with postoperative radiation therapy for low/intermediate grade parotid cancer in these patients.MethodsBetween 1999 and 2006, 17 patients underwent postoperative radiation therapy at Beth Israel Medical Center for acinic cell carcinoma or low‐intermediate‐grade mucoepidermoid carcinoma of the parotid with close/positive margins. Pathology, treatment, and follow‐up data were retrospectively analyzed for morbidity and local control. Two‐ and 5‐year estimates of survival outcomes were performed followed by an analysis of complications.ResultsThere were no local failures and no significant long‐term complications.ConclusionsPatients with small, low‐risk cancer of the parotid gland have excellent local control and low treatment‐related morbidity when receiving postoperative radiation therapy for positive or close margins of resection. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Non‐integrating lentiviral vectors for specific killing of Epstein–Barr virus nuclear antigen 1‐positive B cell lymphoma cells
Authors: Flynn Ryan P. , Zacharias Jeana , Zhou Xianzheng , Cannon Mark L. , Philpott Nicola J. 
Published: August 2011

AbstractBackgroundEpstein–Barr virus (EBV) causes a range of life‐threatening B‐lymphocyte malignancies but, despite the use of various strategies, treatment remains problematic.MethodsIn the present study, we developed a non‐integrating lentiviral vector (NILV) that mediates specific killing of EBV nuclear antigen 1 (EBNA1)‐expressing cells with minimal toxicity to EBNA1‐negative cells. The EBV family of repeats (FR) was cloned intok the NILV genome upstream of various transgenes.ResultsThe presence of the FR in the NILV genome induced transcriptional up‐regulation and prolonged the expression of a transgene specifically in EBNA1‐positive B cells. Transgene expression from an FR‐containing NILV was also prolonged in EBV‐transformed cells compared to an FR‐negative NILV. We found that the delivery of an FR‐containing NILV encoding herpes simplex virus 1 thymidine kinase (TK) lead to the killing of more than 99% of EBNA1‐positive B cells with minimal toxicity to EBNA1‐negative cells in the presence of gancyclovir. EBNA1‐positive cells were not killed by an FR‐negative vector containing the TK gene. An FR‐TK‐containing NILV also specifically killed EBNA1‐containing cells in a mixed population of EBNA1‐positive and EBNA1‐negative cells, thus confirming that NILV‐FR‐TK‐mediated killing is specific for EBNA1‐expressing cells.ConclusionsTransgene expression from our NILVs is both EBNA1‐specific and dependent upon the presence of the FR. The results obtained in the present study indicate that NILVs have potential use in the treatment of EBV‐associated B cell malignancies. Copyright © 2011 John Wiley & Sons, Ltd.
Is extreme Arctic sea ice anomaly in 2007 a key contributor to severe January 2008 snowstorm in China?
Authors: Na Liu , Jiping Liu , Zhanhai Zhang , Hongxia Chen , Mirong Song 
Published: August 2011

AbstractWe conduct numerical experiments with an atmospheric general circulation model to answer the question whether the extreme Arctic sea ice anomaly in 2007 contributed to the severe January 2008 snowstorm in China. Results show that the record low Arctic sea ice in September 2007, and follow‐up slow recovery of the Arctic sea ice in October and November 2007 could excite two stationary wave structures. One wave train propagates southeastward from the Barents/Kara Seas to central Asia, strengthening the Middle East Jet Stream (MEJS), and the other wave train propagates southward from central Arctic Ocean/eastern Siberia Sea to the mid‐latitude and subtropics of the north Pacific, weakening the East Asian Jet Stream (EAJS). The anomalous westerlies associated with the strengthening of the MEJS and the anomalous easterlies associated with the weakening of the EAJS form a strong convergence zone over central and southern China, providing favorable conditions for the severe January 2008 snowstorm. Copyright © 2011 Royal Meteorological Society
Guidelines of a Unified Approach for Product and Business Process Modeling in Complex Enterprise
Authors: Corallo Angelo , De Paolis Paolo , Ippoliti Monica , Lazoi Mariangela , Scalvenzi Massimo , Secundo Giustina 
Published: August 2011

PurposeMany differences exist between a generic process representation and the real flow of activities performed in relation to specific products/programs within an enterprise. The product life cycle modeling approach allows us to model the temporal flow of activities from conceptualization to disposal of specific product/program. In contrast, the business process modeling approach provides a general process perspective. The two views taken alone are not entirely satisfactory. This paper aims to propose a unified and integrated product–business process modeling approach, which overcomes the limitations inherent in adopting a single perspective, maintaining as much as possible, the essential characteristics and strengths of both modeling approaches.Design/methodology/approachThe conceptual model of the proposed unified approach is based on the review of existing process and product modeling theories and on an inductive perspective emerging from the observation of the organizational practices in a number of Italian aerospace companies.FindingsThe proposed approach is expressed in eight guidelines, which describe a new unifying perspective to be adopted in different domains, which ensure that managers identify the assets and activities that are associated with each product that an organization creates. Constraints are also suggested. Some practical applications and examples using the software, aris (IDS Scheer, Saarland, Germany) are also provided based on actual practices in an aerospace company.Originality/valueThis paper describes a new unifying perspective for a combination of product/business process modeling view. Copyright © 2011 John Wiley & Sons, Ltd.
Present state of immunosuppressive therapy in liver transplant recipients
Authors: Wiesner Russell H. , Fung John J. 
Published: August 2011

Key Points
1. Our increasing understanding of the signaling pathways and cellular interactions in transplant immunobiology has facilitated targeted strategies using novel immunosuppressive agents.
2. The pattern of immunosuppressive drug use in the United States continues to change, and the changes include the use of antibody induction therapy and the agents used in maintenance therapy.
3. The driving forces behind the development of new immunosuppressive regimens are the long-term complications of current immunosuppressive regimens (particularly renal dysfunction and metabolic disturbances).
Hepatocellular carcinoma: Agents and concepts for preventing recurrence after curative treatment
Authors: Schlitt Hans J. , Schnitzbauer Andreas A. 
Published: August 2011

Key Points
1. Adjuvant/neoadjuvant chemotherapy.
2. Neoadjuvant transarterial chemoembolization.
3. Kinase inhibitors (eg, sorafenib).
4. Antiviral treatment.
5.Immunosuppressive treatment after liver transplantation.
6. Disseminated tumor cells: the basis for innovative treatment options?