bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interval-Censored Data with Repeated Measurements and a Cured Subgroup
Authors: Li Jialiang , Ma Shuangge 
Published: February 2010

SummaryThe hypobaric decompression sickness data study was conducted by the National Aeronautics and Space Administration to investigate the risk of decompression sickness in hypobaric environments. The quantity of interest is the time to onset of grade IV venous gas emboli, which was mixed case interval censored because of measurement limitations. In the study, some subjects participated in multiple experiments, leading to repeated and correlated measurements on those subjects. In addition, it has been suggested that some subjects had a much lower risk of developing grade IV venous gas emboli than others, i.e. those subjects were immune from the event of interest (or ‘cured’). We propose to use two-part models, where the first part describes the probability of cure and the second part describes the survival for susceptible subjects. We use two random effects to account for the correlated nature of measurements. A leverage bootstrap approach is proposed for model diagnosis. A simulation study shows satisfactory performance of the estimation and diagnosis approaches proposed. Model estimation and evaluation of the hypobaric decompression sickness data are carefully investigated.
Effect of Net Fiber Reinforcement Surface Treatment on Soft Denture Liner Retention and Longevity
Authors: Hatamleh Muhanad M. , Maryan Christopher J. , Silikas Nick , Watts David C. 
Published: February 2010

Abstract Purpose: To evaluate shear bond strength of Molloplast‐B soft liner attached to different acrylic surfaces (smooth, rough, and Sticktech net fiber‐reinforced interfaces) after 3000 thermal cycles. Materials and Methods: Sixty‐nine specimens were fabricated by attaching Molloplast‐B soft liner to acrylic bases of three interfaces (n= 23); smooth (Group 1, control), rough (Group 2), and Sticktech net fiber‐reinforced interface (Group 3). The specimens underwent 3000 thermocycles (5 and 55°C) before being subject to a shear bond test at 2 mm/min crosshead speed. Debonding sites were investigated using an optical microscope at 40× magnification. Bond failures were categorized as adhesive, cohesive, or mixed. Results: Mean (SD) bond strength values (MPa) were: 0.71 (0.15); 0.63 (0.07); and 0.83 (0.12) for smooth, rough, and fiber‐reinforced acrylic interfaces, respectively. The mean values were analyzed using one‐way ANOVA and Bonferroni post hoc test for pairwise comparisons (p≤ 0.05). The net fiber‐reinforced acrylic interface exhibited a statistically significantly higher bond strength value when compared to smooth and rough acrylic interfaces (P= 0.003 and P= 0.000, respectively). Modes of failure were mainly cohesive (91%), followed by mixed failures (9%). Conclusions: Molloplast‐B exhibited a stronger bond to StickTech Net fiber‐reinforced surfaces when compared to smooth and rough acrylic interfaces after thermocycling. This may enhance prosthesis serviceability during clinical use.
CD10‐positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma
Authors: Clarke Loren E. , Frauenhoffer Elizabeth , Fox Edward , Neves Rogerio , Bruggeman Richard D. , Helm Klaus F. 
Published: February 2010

CD10 is now commonly used to differentiate atypical fibroxanthoma (AFX) from melanoma, spindle cell and dedifferentiated variants of squamous cell carcinoma and leiomyosarcoma. However, we have encountered CD10‐positive tumors that mimicked AFX but proved to be myxofibrosarcomas. The purpose of this study was to evaluate CD10 expression in a wide range of mesenchymal neoplasms that may involve the skin using tissue microarrays. Our results indicate that in addition to AFX, CD10 expression is common in myxofibrosarcomas, undifferentiated pleomorphic sarcomas, dermatofibromas and dermatofibrosarcoma protuberans. Myxofibrosarcomas commonly present in the skin and may be difficult to distinguish from AFX on small biopsies and CD10 positivity may confound the diagnostic difficulty.Clarke LE, Frauenhoffer E, Fox E, Neves R, Bruggeman RD, Helm KF. CD10‐positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma.
BCL10 as a new candidate gene for immune response in pigs: cloning, expression and association analysis
Authors: Huang J. , Ma G.‐J. , Sun N.‐N. , Wu Z.‐F. , Li X.‐Y. , Zhao S.‐H. 
Published: February 2010

SummaryBCL10 is an apoptotic regulatory molecule identified through its direct involvement in t(1; 14)(p22; q32) of mucosa‐associated lymphoid tissue lymphoma, and was implicated in the pathogenesis of this and several other tumour types. BCL10 was recognized as an antigen receptor‐specific regulator of NF‐κB, which showed close association with immune responses. In this study, we cloned and characterized BCL10 from the porcine spleen and analysed its genomic structure. BCL10 was mapped to SSC4q21–q23 by the IMpRH panels, it is closely linked to the marker S0161 and SW1461. This gene has three exons and two introns. Reverse transcriptase‐polymerase chain reaction analyses showed that BCL10 was widely expressed in all the examined tissues. Transient transfection indicated that porcine BCL10 was located in cytoplasm in Pig Kidney Epithelial cells. BCL10 gene displays the opposite expression trend between the two treatments mimic virus and bacteria of polyriboinosinic‐polyribocytidylic acid (Poly I:C) and lipopolysaccharide (LPS). The level of the BCL10 mRNA was up‐regulated during 12–24 h and peaking at 48 h when treated with LPS, whereas it was down‐regulated during 0–48 h and highest at 0 h (cells without treating with Poly I:C) when treated with Poly I:C. One single nucleotide polymorphism (SNP) site was identified in the 3′‐untranslated region of porcine BCL10. Association analysis revealed that this SNP was significantly associated with intermediate cell mass (eosinophile granulocyte, basophile granulocyte and histoleucocyte) percentage, absolute intermediate cell mass count and mean red blood cell volume of 0‐day‐old pigs, and red blood cell count of 17‐day‐old pigs (P < 0.05), and also had significant associations with red blood cell count and haemoglobin concentration of 32‐day‐old pigs (P < 0.01).
Heavy chain myosin 9-related disease (MYH9-RD): Neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder
Authors: Rocco Daniela De , Panza Emanuele , Bozzi Valeria , Scandellari Raffaella , Loffredo Giuseppe , Mumford Andrew , Heller Paula , Noris Patrizia , De Groot Marco , Giani Marisa , Freddi Paolo , Scognamiglio Francesca , Riondino Silvia , Pujol-Moix Núria , Fabris Fabrizio , Seri Marco , Balduini Carlo , Pecci Alessandro , Savoia Anna 
Published: February 2010

Summary
MYH9-related disease (MYH9-RD) is an autosomal dominant thrombocytopenia with giant platelets variably associated with young-adult onset of progressive sensorineural hearing loss, presenile cataract, and renal damage. MYH9-RD is caused by mutations of MYH9, the gene encoding for non-muscle heavy-chain myosin-9. Wild-type and mutant myosin-9 aggregate as cytoplasmic inclusions in patients’ leukocytes, the identification of which by immunofluorescence has been proposed as a suitable tool for the diagnosis of MYH9-RD. Since the predictive value of this assay, in terms of sensitivity and specificity, is unknown, we investigated 118 consecutive unrelated patients with a clinical presentation strongly consistent with MYH9-RD. All patients prospectively underwent both the immunofluorescence assay for myosin-9 aggregate detection and molecular genetic analysis of the MYH9 gene. Myosin-9 aggregates were identified in 82 patients, 80 of which (98%) had also a MYH9 mutation. In the remaining 36 patients neither myosin-9 aggregates nor MYH9 mutations were found. Sensitivity and specificity of the immunofluorescence assay was evaluated to be 100% and 95%, respectively. Except for the presence of aggregates, we did not find any other significant difference between patients with or without aggregates, demonstrating that the myosin-9 inclusions in neutrophils are a pathognomonic sign of the disease. However, the identification of the specific MYH9 mutation is still of importance for prognostic aspects of MYH9-RD.
Age is a determinant factor for measures of concentration and effect in children requiring unfractionated heparin
Authors: Ignjatovic Vera , Johnston Linda , Summerhayes Robyn , Lane Geoff , Cranswick Noel , Monagle Paul , Newall Fiona 
Published: February 2010

SummaryPrevious studies investigating continuous unfractionated heparin (UFH) therapy report age-related differences in UFH response in children, as measured by APTT and anti-Xa assay. This study determined the age-related response following administration of a single UFH bolus of 75–100 IU/kg in children. Venous blood samples were collected from children (n=56) at 15, 30, 45 and 120 minutes post-UFH. Anti-Xa, anti-IIa, APTT, TCT and protamine titration were performed on all samples. Age-dependent differences in the effect and concentration of UFH were identified for the anti-Xa, anti-IIa and protamine titration as-says, respectively. In addition, a trend suggesting a proportional increase in anti-Xa and anti-IIa-mediated UFH effect with age was evident. Logistic regression demonstrated an increase in protamine titration of 0.6 IU/ml for every year of age in samples collected 15 minutes post-UFH. UFH-mediated anti-IIa activity was reduced compared to anti-Xa activity across childhood, with a two-fold increase in anti-Xa to anti-IIa ratio in infants less than one year of age compared to teenagers in the setting of high UFH concentrations. This study demonstrates that the previously reported age-dependent response to UFH occurs in the context of an age-dependent serum concentration of UFH. The trend toward increased UFH serum concentration and anticoagulant activity with age may be related to short-term differences in UFH binding to coagulant and competitive plasma proteins in vivo.
Differences in the progression of primary progressive multiple sclerosis in Brazilians of African descent versus white Brazilian patients
Authors: Ferreira Vasconcelos Claudia Cristina , Santos Thuler Luiz Claudio , Cruz dos Santos Gutemberg Augusto , Papais Alvarenga Marcos , Papais Alvarenga Marina , Gomes Camargo Solange Maria das Graças , Papais Alvarenga Regina Maria 
Published: February 2010

Recent studies have suggested faster clinical progression and greater disability in multiple sclerosis patients of African descent. This study analysed the effect of ethnicity on progression and disability. Sixty-five patients with primary progressive multiple sclerosis were selected and classified as being of African descent or white. Time from onset of the disease until reaching Expanded Disability Status Scale grades 3, 6, and 8 was assessed, as well as irreversible disability (Expanded Disability Status Scale grade maintained for ≥6 months). In the African descent group, the median time to reach Expanded Disability Status Scale 3 was 1 year shorter (1 year vs 2 years, p= 0.02), and to reach Expanded Disability Status Scale 6 was 2 years shorter (3 years vs 5 years, p= 0.01) than in the group of white patients. According to the Kaplan—Meier survival curves, patients of African descent reached every disability stage faster than white patients ( p= 0.03, p = 0.04, and p = 0.03, respectively, for Expanded Disability Status Scale grades 3, 6, and 8). As in United States and European patients of African descent, the more severe and faster progression of multiple sclerosis seen in Brazilian primary progressive multiple sclerosis patients of African descent suggests a possibly greater effect of ethnicity rather than environment on the progression of multiple sclerosis.
Bacterial diversity and reductive dehalogenase redundancy in a 1,2-dichloroethane-degrading bacterial consortium enriched from a contaminated aquifer
Authors: Marzorati Massimo , Balloi Annalisa , de Ferra Francesca , Corallo Lorenzo , Carpani Giovanna , Wittebolle Lieven , Verstraete Willy , Daffonchio Daniele 
Published: February 2010

Abstract

Background
Bacteria possess a reservoir of metabolic functionalities ready to be exploited for multiple purposes. The use of microorganisms to clean up xenobiotics from polluted ecosystems (e.g. soil and water) represents an eco-sustainable and powerful alternative to traditional remediation processes. Recent developments in molecular-biology-based techniques have led to rapid and accurate strategies for monitoring and identification of bacteria and catabolic genes involved in the degradation of xenobiotics, key processes to follow up the activities in situ.

Results
We report the characterization of the response of an enriched bacterial community of a 1,2-dichloroethane (1,2-DCA) contaminated aquifer to the spiking with 5 mM lactate as electron donor in microcosm studies. After 15 days of incubation, the microbial community structure was analyzed. The bacterial 16S rRNA gene clone library showed that the most represented phylogenetic group within the consortium was affiliated with the phylum Firmicutes. Among them, known degraders of chlorinated compounds were identified. A reductive dehalogenase genes clone library showed that the community held four phylogenetically-distinct catalytic enzymes, all conserving signature residues previously shown to be linked to 1,2-DCA dehalogenation.

Conclusions
The overall data indicate that the enriched bacterial consortium shares the metabolic functionality between different members of the microbial community and is characterized by a high functional redundancy. These are fundamental features for the maintenance of the community's functionality, especially under stress conditions and suggest the feasibility of a bioremediation treatment with a potential prompt dehalogenation and a process stability over time.
"The non-ischemic repair" as a safe alternative method for repair of anterior post-infarction VSD
Authors: Apostolakis Efstratios E , Kallikourdis Antonios , Baikoussis Nikolaos G , Dedeilias Panagiotis , Dougenis Dimitrios 
Published: February 2010

Abstract
Patient's myocardium with post-infarction ventricular septum defect (VSD) is characterized by severe dysfunction. The "additive ischemia" caused by the operating process of cross-clamp ischemia and reperfusion injury, has a significant aggravation to the myocardium and overall negative impact to patient's outcome. We present a useful, safe and advantageous methodology in order to abolish "the toxic phase" of ischemia-reperfusion which is adopted by most as the "classic repair method" of myocardial protection. This abolition is in our opinion, particularly beneficial in order to reverse postoperatively the Low Cardiac Output Syndrome (LOS) and achieve better short and long term results. By using this method we avoid the aortic occlusion, the use of systematic hypothermia and any cardioplegic arrest. Furthermore, the total cardio-pulmonary bypass (CPB) time is significantly reduced, tissue debridement and stitching is much easier and safer. We think the method is applicable for every anterior and apical case of post-infarction septum rupture. After application of method in 3 patients with anterior post-myocardial infarction VSD, we are convinced that the patient will have a better postoperative haemodynamic condition and therefore a better outcome.
Silver Lining: Building a Shared Sudanese Identity through Food
Authors: crofts a.v. 
Published: February 2010

The displaced of Sudan, due to both decades of civil war and natural disasters, are disproportionately female and many are responsible for dependents. For those settling in the capital, Khartoum, their livelihood depends on carving out ways to earn money in an urban area that is experiencing tremendous growth from the millions of recent arrivals. When confronted with the immediate need to provide for their families, women turn to a skill universally expected of them: cooking.
Therefore, Khartoum is home to a thriving micro-economy of food vendors. By selling these dishes in the capital, they broaden the culinary horizons of the city while preserving their own food traditions. Their growing numbers provide an opportunity for regional foodways to gain wider introduction, adaptation, and, finally, adoption.
These same vendors also facilitate a nascent sense of a shared Sudanese identity and nationalism. For established Khartoum urbanites, the definition of Sudanese food (and, by extension, what it means to be Sudanese) expands as street-vendor fare moves to restaurants and becomes more widely available throughout the city. As urban Sudanese overcome their preconceptions and discover a taste for regional cuisines, meals function as unofficial diplomacy during this turbulent time in Sudan's history.
Meta-Synthesis of Health Behavior Change Meta-Analyses
Authors: Johnson Blair T. , Scott-Sheldon Lori A.J. , Carey Michael P. 
Published: February 2010

Objectives. We integrated and compared meta-analytic findings across diverse behavioral interventions to characterize how well they have achieved change in health behavior. Methods. Outcomes from 62 meta-analyses of interventions for change in health behavior were quantitatively synthesized, including 1011 primary-level investigations with 599 559 participants. Content coding suggested 6 behavioral domains: eating and physical activity, sexual behavior, addictive behaviors, stress management, female-specific screening and intervention behaviors, and behaviors involving use of health services. Results. Behavior change interventions were efficacious (mean effect sizes = 0.08–0.45). Behavior change was more evident in more recent meta-analyses; those that sampled older interventions and literatures or sampled more published articles; those that included studies that relied on self-report, used briefer interventions, or sampled fewer, older, or female participants; and in some domains (e.g., stress management) more than others (e.g., sexual behaviors). Conclusions. Interventions improved health-related behaviors; however, efficacy varied as a function of participant and intervention characteristics. This meta-synthesis provides information about the efficacy of behavioral change interventions across health domains and populations; this knowledge can inform the design and development of public health interventions and future meta-analyses of these studies.
Retirement at the Turn of the Twentieth Century: A Canadian Perspective
Authors: Dillon Lisa , Gratton Brian , Moen Jon 
Published: February 2010

Abstract: In late-nineteenth-century North America, privately financed retirement emerged as a recognized phenomenon. While scholars acknowledge these origins, the prevalence of retirement remains intensely debated. The 1901 Canadian census explicitly required the enumerator to ask respondents if they had retired. The question makes it possible to correct estimates of labour force participation that are biased upward by the known tendency of men to report their lifelong occupation, even if they had retired. It also permits a separate consideration of this life stage well before formal retirement under public and private pension systems. An analysis of older men's responses from a 5 per cent sample of the 1901 Canadian census demonstrates that retirement was much more extensive than can be calculated from occupational reporting. While most older men reported an occupation and did not report retirement, over a fifth of those in their seventies and eighties reported an occupation but appear to have retired from it. Such a dual report was linked to greater age, being a farmer, urban status, and residence in Ontario. It was also associated with not owning property and a dependent status within households.
Stereotactic electroencephalography with temporal grid and mesial temporal depth electrode coverage: does technique of depth electrode placement affect outcome?
Authors: Van Gompel Jamie J. , Meyer Fredric B. , Marsh W. Richard , Lee Kendall H. , Worrell Gregory A. 
Published: February 2010

Object
Intracranial monitoring for temporal lobe seizure localization to differentiate neocortical from mesial temporal onset seizures requires both neocortical subdural grids and hippocampal depth electrode implantation. There are 2 basic techniques for hippocampal depth electrode implantation. This first technique uses a stereotactically guided 8-contact depth electrode directed along the long axis of the hippocampus to the amygdala via an occipital bur hole. The second technique involves direct placement of 2 or 3 4-contact depth electrodes perpendicular to the temporal lobe through the middle temporal gyrus and overlying subdural grid. The purpose of this study was to determine whether one technique was superior to the other by examining monitoring success and complications.

Methods
Between 1997 and 2005, 41 patients underwent invasive seizure monitoring with both temporal subdural grids and depth electrodes placed in 2 ways. Patients in Group A underwent the first technique, and patients in Group B underwent the second technique.

Results
Group A consisted of 26 patients and Group B 15 patients. There were no statistically significant differences between Groups A and B regarding demographics, monitoring duration, seizure localization, or outcome (Engel classification). There was a statistically significant difference at the point in time at which these techniques were used: Group A represented more patients earlier in the series than Group B (p < 0.05). The complication rate attributable to the grids and depth electrodes was 0% in each group. It was more likely that the depth electrodes were placed through the grid if there was a prior resection and the patient was undergoing a new evaluation (p < 0.05). Furthermore, Group A procedures took significantly longer than Group B procedures.

Conclusions
In this patient series, there was no difference in efficacy of monitoring, complications, or outcome between hippocampal depth electrodes placed laterally through temporal grids or using an occipital bur hole stereotactic approach. Placement of the depth electrodes perpendicularly through the grids and middle temporal gyrus is technically more practical because multiple head positions and redraping are unnecessary, resulting in shorter operative times with comparable results.