bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nutrient acquisition and limitation for the photoautotrophic growth of Synechocystis sp. PCC6803 as a renewable biomass source
Authors: Kim Hyun Woo , Vannela Raveender , Zhou Chao , Rittmann Bruce E. 
Published: September 2010

AbstractPhotoautotrophic microorganisms (cyanobacteria and algae) offer high promise as a source of biomass for renewable energy due to their rapid growth rates and high biomass yields. To provide a framework for evaluating the feasibility of growing phototrophic microorganisms with high biomass production rates, we operated a bench‐scale photobioreactor using Synechocystis sp. PCC6803 and with light conditions imitating actual day–night light irradiance (LI). During the time of peak LI, PCC6803's specific growth rate (1.7 day−1) and the nitrate uptake rate (0.46 g N/g DW day) were high compared to past reports. Analysis employing the stoichiometry of photosynthesis of PCC6803 and ionic speciation showed that bicarbonate and phosphate were driven to very low concentrations for the high‐LI conditions. In particular, the systematic evaluation of rate‐limiting factors identified when the CO2–Ci supply rate needed to be increased to mitigate HCO depletion and a large pH increase. It also showed that the traditional BG‐11 medium needs to be augmented with phosphate to avoid severe P depletion. This work exploits quantitative understanding the stoichiometry and kinetics of cyanobacteria for the high‐rate production of a renewable biomass. Biotechnol. Bioeng. 2011;108: 277–285. © 2010 Wiley Periodicals, Inc.
The effect of the psychopathy checklist – revised in capital cases: Mock jurors' responses to the label of psychopathy
Authors: Cox Jennifer , DeMatteo David S. , Foster Elizabeth E. 
Published: September 2010

AbstractDespite mixed empirical evidence regarding the ability of the Psychopathy Checklist – Revised (PCL‐R) to predict violence among incarcerated inmates, it continues to be used to address such questions, even in the context of capital cases. The purpose of this study was to examine if the PCL‐R has a prejudicial effect on mock jury members during the sentencing phase of a capital murder trial. Results indicated that participants were more likely to sentence the defendant to death when the defendant exhibited a high likelihood to commit future violence, whether or not the diagnostic label “psychopath” was present. Interestingly, when asked to rate the defendant's likelihood for future violence and murder, the defendant who was a high risk for future violence and not labeled a psychopath received the highest rating. These results suggest an absence of juror bias as it pertains to the label “psychopath” when sentencing a defendant in a capital murder case. Copyright © 2010 John Wiley & Sons, Ltd.
Redox homeostasis phenotypes in RubisCO‐deficient Rhodobacter sphaeroides via ensemble modeling
Authors: Rizk Matthew L. , Laguna Rick , Smith Kevin M. , Tabita F. Robert , Liao James C. 
Published: September 2010

AbstractPhotosynthetic bacteria are capable of carrying out the fundamental biological processes of carbon dioxide assimilation and photosynthesis. In this work, ensemble modeling (EM) was used to examine the behavior of mutant strains of the nonsulfur purple photosynthetic bacterium Rhodobacter sphaeroides containing a blockage in the primary CO2 assimilatory pathway, which is responsible for cellular redox balance. When the Calvin–Benson–Bassham (CBB) pathway is nonfunctional, spontaneous adaptive mutations have evolved allowing for the use of at least two separate alternative redox balancing routes enabling photoheterotrophic growth to occur. The first of these routes expresses the nitrogenase complex, even in the presence of normal repressing ammonia levels, dissipating excess reducing power via its inherent hydrogenase activity to produce large quantities of hydrogen gas. The second of these routes may dissipate excess reducing power through reduction of sulfate by the formation of hydrogen sulfide. EM was used here to investigate metabolism of R. sphaeroides and clearly shows that inactivation of the CBB pathway affects the organism's ability to achieve redox balance, which can be restored via the above‐mentioned alternative redox routes. This work demonstrates that R. sphaeroides is capable of adapting alternative ways via mutation to dissipate excess reducing power when the CBB pathway is inactive, and that EM is successful in describing this behavior. © 2010 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Transcatheter closure of ruptured sinus of valsalva aneurysm
Authors: Kumar Prabhat , Banerji Anup 
Published: September 2010

AbstractCongenital sinus of Valsalva aneurysm is a rare cardiovascular anomaly. Rupture of sinus of Valsalva (RSOV) is a rare occurrence, occurring in 10–20% of cases. Rupture into right atrium is further a rare occurrence. The rupture is usually a catastrophic event presenting as acute onset congestive cardiac failure in an apparently healthy individual in the 2nd or 3rd decade of life. Surgery used to be the mainstay of treatment of RSOV aneurysm, however, in past few years several reports of transcatheter closure of RSOV have come into light. We report a patient, who underwent device closure with a Duct Occluder device. Device was manipulated and deployed with an angle so as to prevent aortic valve dysfunction. © 2010 Wiley‐Liss, Inc.
Transcatheter aortic valve implantation for treatment of patients with degenerated aortic bioprostheses—valve‐in‐valve technique
Authors: Gotzmann Michael , Mügge Andreas , Bojara Waldemar 
Published: September 2010

AbstractBackground: The management of patients with degeneration of surgical bioprosthetic valve replacement remains a challenge because of the higher risk of re‐do aortic valve replacement. We present a case series of five patients with degenerated aortic bioprostheses treated with transfemoral transcatheter aortic valve implantation (TAVI). Methods: From December 2009 to May 2010, five patients with degenerated aortic valve bioprostheses (aortic valve area < 1 cm2 or severe aortic regurgitation), an excessive operative risk (EuroSCORE ≥ 30%), symptoms of heart failure (NYHA ≥ III) and an internal diameter of bioprosthetic aortic valve 20.5 ± 0.5 mm were included. Procedures were performed without hemodynamic support using femoral arteries. Balloon valvuloplasty with a 20‐mm balloon under rapid pacing was carried out before valve implantation. The 26‐mm CoreValve prosthesis, 18‐F‐generation (Medtronic, Minneapolis, Minnesota) was inserted retrograde under fluoroscopic guidance. Invasive and echocardiographic measurements were done immediately before and after TAVI. Clinical followup and echocardiography were performed after procedure (mean followup 72 days ± 60, range: 176–30 days). Results: In all patients TAVI was successful with immediate decrease of transaortic peak‐to‐peak pressure (P = 0.002). Mild aortic regurgitation occurred in two patients and one patient received a new permanent pacemaker. Major adverse cardiac and cerebrovascular events did not arise. NYHA functional class improved in all patients and left ventricular ejection fraction increased (P = 0.019). Conclusion: Our experiences with the valve‐in‐valve technique using the CoreValve prosthesis suggest that transfemoral TAVI is feasible in high risk patients with degenerated aortic bioprostheses. © 2010 Wiley‐Liss, Inc.
Sheathless transradial intervention using standard guide catheters
Authors: From Aaron M. , Gulati Rajiv , Prasad Abhiram , Rihal Charanjit S. 
Published: September 2010

AbstractObjectives:Our aim was to report our preliminary experience performing complex transradial interventions using a sheathless technique with standard large bore nonhydrophilic guiding catheters.Background:A major limitation of transradial percutaneous coronary intervention (PCI) is the inability to use large guides because of the relatively small size of the radial artery.Methods:We identified consecutive patients who had transradial PCI between September 2009 and March 2010 using large‐bore guides (7 or 8 Fr) with a sheathless technique.Results:Ten patients were identified (90% men, mean age 68.8 ± 9.8 years). Indications for PCI were stable angina (60%) and acute coronary syndrome (40%). Treatment was attempted on 15 vessels. Bifurcation lesions were present in six patients. One patient had a chronic total occlusion, one had a saphenous vein bypass graft lesion requiring filter wire placement prior to intervention, and one patient required rotational atherectomy. In the majority of patients (60%) a 7‐Fr guiding catheter was used for the intervention; 8‐Fr guide catheters were used four patients. PCI was unsuccessful in one vessel; this was a completely occluded obtuse marginal which could not be crossed. There were no radial artery access site complications and in no case was cross‐over to a femoral artery access site required. One minor coronary complication occurred.Conclusions:Sheathless transradial PCI using standard large‐bore guiding catheters is a safe and effective method for treatment of complex lesions. © 2010 Wiley‐Liss, Inc.
Long‐term risk of clinical events from stenting side branches of coronary bifurcation lesions with drug‐eluting and bare‐metal stents: An observational meta‐analysis
Authors: Zamani Payman , Kinlay Scott 
Published: September 2010

AbstractObjectives: To compare the long‐term risks of coronary bifurcation lesions treated with side‐branch stenting using drug‐eluting versus bare‐metal stents. Background: Side‐branch stenting is an off‐label practice, but when needed, the incidence of late adverse events may differ between drug‐eluting and bare‐metal stents. Methods: We systematically searched PubMed, and the National Institutes of Health and Cochrane Registries for studies of coronary bifurcation stenting reporting clinical outcomes over at least 5 months. Data were extracted and cross checked independently by two investigators for inclusion in an observational meta‐analysis. Clinical outcomes included major adverse clinical events (MACE), death, myocardial infarction, target vessel revascularization (TVR), and definite stent thrombosis. We used random‐effects models and meta‐regression in 6,825 subjects from 42 studies. Results: Most (79%) of the heterogeneity in MACE between treatment groups was explained by differences in stent type, side‐branch stenting, and length of follow‐up. Compared with drug‐eluting stents without side‐branch stenting, drug‐eluting stents with side‐branch stenting had a 3% higher incidence of myocardial infarction [95% confidence interval (CI) = 0.3%, 5%, P < 0.05], but no significant increase in MACE, death, TVR, or stent thrombosis. Bare‐metal stenting without side‐branch stenting had 10% (95% CI = 3%, 16%, P < 0.01) higher MACE, and 10% (95% CI = 4%, 17%, P < 0.01) higher TVR, whereas bare‐metal side‐branch stenting had 31% (95% CI = 23%, 39%, P < 0.001) higher MACE, and 19% (95% CI = 10%, 28%, P < 0.001) higher TVR. Conclusions: Side‐branch stenting has a much smaller impact on long‐term MACE with drug‐eluting stents compared with bare‐metal stents. Although this study does not support routine side‐branch stenting, when side‐branch stenting is required, drug‐eluting stents are associated with less adverse outcomes.© 2011 Wiley‐Liss, Inc.
Five‐year clinical outcomes of sirolimus‐eluting versus paclitaxel‐eluting stents in high‐risk patients
Authors: Birkmeier K. Anette , Kastrati Adnan , Byrne Robert A. , Holle Heidrun , Schulz Stefanie , Tiroch Klaus , Kufner Sebastian , Massberg Steffen , Laugwitz Karl‐Ludwig , Schömig Albert , Mehilli Julinda 
Published: September 2010

AbstractObjectives and Background: First generation drug‐eluting stents have shown differential efficacy in high‐risk patient subsets at one year. It is unclear whether these differences endure over the medium‐ to long‐term. We compared the five‐year clinical efficacy and safety of sirolimus‐eluting stents (SES) and paclitaxel‐eluting stents (PES) in a population of high‐risk patients. Methods: The patient cohorts of the ISAR‐DESIRE, ISAR‐DIABETES, and ISAR‐SMART‐3 randomized trials were followed up for five years and data were pooled. The primary efficacy endpoint of the analysis was the need for target lesion revascularization (TLR) during a five‐year follow‐up period. The primary safety endpoint was the combination of death or myocardial infarction (MI) after five years. Results: A total of 810 patients (405 patients in the SES group and 405 patients in the PES group) was included. Over five years TLR was reduced by 39% with SES compared with PES stent (hazard ratio [HR] 0.61; 95% confidence interval [CI] 0.44–0.85; P = 0.004). No difference was observed according to death or MI rates between the two groups (HR 1.10; 95% CI 0.80–1.50; P = 0.57). Definite stent thrombosis occurred in 0.2% (n = 1) in the SES group and in 1.6% (n = 6) in the PES group (HR 0.16; 95% CI 0.02–1.34; P = 0.12). Conclusions: In high‐risk patient subsets the lower rate of 12‐month TLR observed with SES in comparison PES is maintained out to five years. In terms of safety, although there was no difference in the overall incidence of death or MI, there was a trend towards more frequent stent thromboses with PES. © 2011 Wiley‐Liss, Inc.
Complications related to access site after percutaneous coronary interventions
Authors: Crudu Vitalie , Blankenship James , Berger Peter , Scott Thomas , Skelding Kimberly 
Published: September 2010

AbstractObjectives: The primary objective was to compare the NCDR rate of four access site related complications (arteriovenous fistula, pseudoaneurysm, retroperitoneal bleed, and blood transfusion) with that obtained independently within a Quality Improvement (QI) Database. The secondary objective was to determine the in‐hospital mortality related to these complications. Background: NCDR is the most comprehensive database of post‐PCI patients and a method by which hospitals are compared for quality of care and outcomes. The collected data include in‐hospital events only, therefore reporting for same day and/or early discharges may fail to capture adverse events. We hypothesized that the actual rate of complications post‐PCI may be higher than the rate reported in NCDR. Methods: Adverse events following PCIs were collected in a QI database. We compared the rate of four abovementioned complications between NCDR and our QI database for the time period between January 1, 2005 and December 31, 2008. Results: A total of 3,940 PCIs were performed on 3,430 patients in the four‐year interval. The incidence of the combined endpoint of the four adverse events was 4.1% (161 events) in NCDR, vs. 4.7% (186 events) in QI database, a 13% higher yield. There was significantly higher in‐hospital mortality in the complication group with regards to both all cause (4.7% vs. 1.1%, P < 0.0001) and cardiovascular mortality (2.7% vs. 1%, P = 0.046). Conclusions: Access site related complications occurred 13% more than what was reported in NCDR and were associated with a greater than fourfold increase in in‐hospital mortality. © 2011 Wiley‐Liss, Inc.
Intracoronary delivery of eptifibatide with the ClearWay® RX infusion catheter
Authors: Deibele Albert J. , Michael Gibson C. 
Published: September 2010

AbstractAcute coronary syndromes are caused by plaque rupture and the formation of an occlusive thrombus. Intracoronary (IC) bolus administration of eptifibatide may result in higher levels of platelet glycoprotein IIb/IIIa (GP IIb/IIIa) receptor occupancy (RO) in the local coronary bed, disaggregate thrombus in the epicardial artery, and microvasculature and thereby improve coronary flow. We report the use of the ClearWay® catheter to deliver IC eptifibatide to the lesion, theoretically thereby achieving higher local coronary concentrations of the eptifibatide, achieving a longer residence time and maximizing drug bioavailability at the site of the thrombus over the standard intravenous delivery mechanism and over intracoronary bolus administration via the guide catheter. This may then lead to superior thrombus disaggregation and improved microvascular perfusion. © 2011 Wiley‐Liss, Inc.
A new technique for shortening a guiding catheter during retrograde recanalization of a chronic total occlusion
Authors: Kim Tae‐Hoon , Jang Yangsoo 
Published: September 2010

AbstractThis report introduces successful retrograde angioplasty of chronic total occlusion with a long collateral channel using a new technique of shortening the guiding catheter. With this method, we secured the lengths of the guidewire and the microcatheter for retrograde intervention without sacrificing the position of the tracked guidewire. © 2010 Wiley‐Liss, Inc.
Efficacy and safety of a double‐coated paclitaxel‐eluting coronary stent: The EUCATAX trial
Authors: Rodriguez Alfredo E. , Vigo Cesar F. , Delacasa Alejandro , Mieres Juan , Fernandez‐Pereira Carlos , Bernardi Victor , Bettinoti Marcelo , Rodriguez‐Granillo Alfredo M. , Rodriguez‐Granillo Gaston , Santaera Omar , Curotto Valeria , Rubilar Bibiana , Tronge Jorge , Palacios Igor F. , Antoniucci David ,   on behalf of EUCATAX Investigators
Published: September 2010

AbstractObjectives: The aim of this study was the comparison of a new double‐coated paclitaxel‐eluting coronary stent with bare‐metal stent (BMS) in patients undergoing percutaneous coronary intervention. Background: Stent coating with biodegradable polymers as a platform for elution of drugs has the potential for complete elution of drugs and for decreasing the risk of late complications. Methods: Multicenter randomized trial comparing a paclitaxel‐eluting stent (PES) coated with a biodegradable polymer and glycocalyx with the equivalent BMS. We randomly assigned 422 patients with de novo coronary lesions to PES (211 patients) or to BMS (211 patients). Primary end point was target vessel failure (TVF) defined as cardiac death, myocardial infarction, and target vessel revascularization. Clinical secondary end points were target vessel revascularization, target lesion revascularization, stent thrombosis (ST), and major adverse cardiovascular events (MACE). Angiographic secondary end points were late loss and binary restenosis. Results: At 1 year of follow‐up, TVF rate was 9.5% in the PES group and 17.1% in the BMS group (P = 0.02), and MACE rate was 10% in PES and 19% in BMS arm (P = 0.009). All other secondary end points were reached but ST. ST rate was low and similar in both study arms. Conclusions: The study shows that patients treated with PES with dual coating technology had significantly lower incidence of TVF and MACE than those treated with BMS design; however, longer follow‐up should be necessary to assess true advantages of this technology compared with the previous one. © 2010 Wiley‐Liss, Inc.
Long‐term outcomes of elective drug‐eluting stenting of the unprotected left main coronary artery in patients with normal left ventricular function
Authors: Lee Michael S. , Yang Tae , Biondi‐Zoccai Giuseppe , Sillano Dario , Cerrato Enrico , Tarantini Giuseppe , Xhaxho Jola , Aragon Joseph , Sheiban Imad 
Published: September 2010

AbstractObjectives:To evaluate the early and long‐term outcomes of patients with normal left ventricular function who undergo elective unprotected left main coronary artery (ULMCA) percutaneous coronary intervention (PCI) with drug‐eluting stents (DES).Background:Although the standard of care for patients with ULMCA disease is coronary artery bypass surgery, the current guidelines recommend PCI in clinical conditions that predict an increased risk of adverse surgical outcomes. The long‐term outcomes of patients with low risk of adverse surgical outcomes who undergo PCI are unknown.Methods:Data from a multicenter international registry, which included 221 consecutive patients from four institutions with normal left ventricular function who underwent elective ULMCA PCI with DES from 2002 to 2009, were collected.Results:There was no cardiac death, Q‐wave myocardial infarction, target lesion revascularization (TLR), stent thrombosis, or stroke within the first 30 days. Seven (3%) patients had periprocedural myocardial infarction. Follow‐up angiography was performed in 136 (62%) patients. Kaplan–Meier event‐free survival curves at 1 year for cardiac death and TLR rates were 97.7% ± 1.0% and 92.9% ± 1.8%, respectively. At the mean follow‐up of 44.8 ± 22.8 months, the event‐free rates for cardiac death and TLR were 95.5% ± 1.5% and 88.9% ± 2.3%, respectively. Multivariate analyses identified the predictors of cardiac death: age ≥ 75 years (P = 0.015) and history of myocardial infarction (P = 0.017).Conclusions:Elective ULMCA PCI with DES in patients with normal left ventricular function is safe and effective with excellent short‐term outcomes and favorable long‐term outcomes and may be a viable option for low‐risk patients with normal left ventricular function. © 2010 Wiley‐Liss, Inc.
The Effect of Grinding Media Performance on Milling a Water‐Based Color Pigment
Authors: Weber U. 
Published: September 2010

AbstractThe effect of grinding media performance on milling and operational behavior is demonstrated for different selected conditions of a water‐based red pigment slurry milling. A variety of grinding media materials and bead sizes, along with two different stirrer tip speeds, are used in the grinding process to reduce the particle size in order to increase the color strength of the red pigment. To determine the optimum milling parameters regarding the particle size and the pigment color, the collected test data is used to calculate and evaluate the specific energy and stress intensity under different milling conditions.
Spectroscopic Implications of the Electron Donor–Acceptor Effect in the Photoactive Yellow Protein Chromophore
Authors: Rocha‐Rinza Tomás , Christiansen Ove , Rahbek Dennis B. , Klærke Benedikte , Andersen Lars H. , Lincke Kasper , Brøndsted Nielsen Mogens 
Published: September 2010

AbstractThe importance of the donor–acceptor push–pull system in the photoabsorption of the trans p‐coumaric acid, the cofactor within the photoactive yellow protein and other xanthopsins, has been investigated. We recorded gas‐phase absorption spectra and performed high‐level quantum chemical calculations of three chromophore models, namely, the deprotonated trans ortho‐, meta‐ and para‐methyl coumarates. The ortho and para isomers, which have the electron‐donating phenoxy oxygen and the electron‐withdrawing acyl group in conjugation, present absorptions in the high‐energy region of the visible spectrum, that is, in the interval of wavelengths in which the photoactivity of the xanthopsins is observed. On the other hand, the meta isomer, in which the conjugation between the phenoxy and acyl groups is disrupted, exhibits a significantly shifted maximum and presents no absorption in the region from blue to ultraviolet A. It is found that the push–pull system in the trans p‐coumaric acid is critical for the wavelength and the intensity of its photoabsorption. Absorption spectra were also measured in methanol and showed an appreciable hypsochromic effect. Linear response calculations within the formalism of the approximate coupled cluster singles and doubles CC2 model and time‐dependent DFT using the functional CAM‐B3LYP provided insights into the relevant processes of excitation and aided to the interpretation of the experimental results. There is good agreement between theory and experiment in the description of the gas‐phase absorption spectra of the considered chromophore models. Differential density plots were used to predict the effect of hydrogen‐bonded amino acids to the trans p‐coumaric acid on the protein tuning of this chromophore.