bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hearing what you pay improves transaction satisfaction? Unveiling the dual process influence of auditory feedback
Authors: Li Aoqi , Huang Minxue , Zhan Mengmeng 
Published: May 2024

AbstractRetailers in certain regions, such as China, have recently implemented auditory feedback in cash registers to promptly announce consumer mobile payment status, but it presents a dual effect on consumers' transaction experiences. On one hand, auditory feedback enhances consumers' sense of control over the payment, leading to increased transaction satisfaction. On the other hand, it also intensifies consumers' pain of payment, resulting in decreased transaction satisfaction. Nevertheless, our study reveals an overall positive effect of auditory feedback on transaction satisfaction. We examined the moderating role of shopping motivation (functional vs. hedonic) and found that auditory feedback can enhance transaction satisfaction for consumers with functional shopping motivation and decrease it for consumers with hedonic shopping motivation. We also explored the moderating role of quick response (QR) code payments (dependent payment vs. autonomous payment) and observed a positive effect of auditory feedback on transaction satisfaction for dependent payment but not for autonomous payment. These findings contribute to the broader research on mobile payments and retailers aiming to enhance consumers' transaction experience.
The Impact of Regiodefects on the Melt‐Memory of Isotactic Polypropylene
Authors: Cicolella Alessandra , De Rosa Claudio , Sepe Eleonora , De Stefano Fabio , Giordano Angelo , Scoti Miriam 
Published: May 2024

AbstractThe memory of crystalline phase in the melt of isotactic polypropylene (iPP) in regiodefective samples of iPP characterized by different concentrations regiodefects, constituted by secondary 2,1 propene units, is studied. The self‐nucleation (SN) experiments have demonstrated that the presence of 2,1 regiodefects produces a strong memory of the crystalline phase in the melt that persists up to temperatures much higher than the melting temperature. The extension of the heterogeneous melt (domain II) containing self‐nuclei increases with increasing the concentration of regiodefects. The higher the concentration of regiodefects the higher the temperature at which the self‐nuclei are dissolved and the homogeneous melt is achieved. This demonstrates that a strong memory of the crystalline phase of iPP in the melt exists not only in copolymers with noncrystallizable bulky comonomeric units rejected from the crystals but even when small defects are largely included in the crystals.
Anlotinib induces neuronal‐like differentiation of neuroblastoma by downregulating CRMP5
Authors: Hu Junwen , Yang Wenlong , Wang Kang , Xu Hongyan , Chen Tianxiang , Li Chao , Xiong Ting , Xu Han , Luo Ming , Zhang Shouhua , Yan Jinlong 
Published: May 2024

AbstractThe therapeutic effect of anlotinib on neuroblastoma is still not fully understood. This study aims to explore the differentiation therapeutic effects of anlotinib on neuroblastoma and its potential association with the neural development regulatory protein collapsin response mediator protein 5 (CRMP5), both in vivo and in vitro. A patient‐derived xenograft (PDX) model was established to observe the therapeutic effect of anlotinib. Neuroblastoma cell lines SK‐N‐SH and SK‐N‐AS were cultured to observe the morphological impact of anlotinib. Transwell assay was used to evaluate the cell invasion, and Western blot analysis and immunohistochemistry were employed to detect the expressions of neuronal differentiation‐related proteins. Results indicate that anlotinib effectively inhibited tumor growth in the PDX model, modulated the expressions of neuronal differentiation markers. In vitro, anlotinib treatment induced neurite outgrowth in neuroblastoma cells and inhibited their invasive ability, reflecting a change in neuronal marker expression patterns consistent with the PDX model. Similarly, in the SK‐N‐AS mouse xenograft model, anlotinib demonstrated comparable tumor‐suppressing effects and promoted neuronal‐like differentiation. Additionally, anlotinib significantly downregulated CRMP5 expression in neuroblastoma both in vivo and in vitro. Overexpression of CRMP5 significantly reversed the differentiation therapy effect of anlotinib, exacerbating the aggressiveness and reducing the differentiation level of neuroblastoma. These findings highlight the potential of anlotinib as an anti‐neuroblastoma agent. It may suppress tumor proliferation and invasion by promoting the differentiation of tumor cells towards a neuronal‐like state, and this differentiation therapy effect involves the inhibition of CRMP5 signaling.
IGF2BP2 inhibits invasion and migration of clear cell renal cell carcinoma via targeting Netrin‐4 in an m6A‐dependent manner
Authors: Wang Gui , Zhuang Tao , Zhen Fei , Zhang Chu , Wang Qichao , Miao Xu , Qi Nienie , Yao Ruiqin 
Published: May 2024

AbstractClear cell renal cell carcinoma (ccRCC), the most common subtype of renal cell carcinoma, often leads to a poor prognosis due to metastasis. The investigation of N6‐methyladenosine (m6A) methylation, a crucial RNA modification, and its role in ccRCC, particularly through the m6A reader insulin‐like growth factor 2 mRNA‐binding protein 2 (IGF2BP2), revealed significant insights. We found that IGF2BP2 was notably downregulated in ccRCC, which correlated with tumor aggressiveness and poor prognosis. Thus, IGFBP2 has emerged as an independent prognostic factor of ccRCC. Moreover, a strong positive correlation was observed between the expression of IGF2BP2 and Netrin‐4. Netrin‐4 was also downregulated in ccRCC, and its lower levels were associated with increased malignancy and poor prognosis. Overexpression of IGF2BP2 and Netrin‐4 suppressed the invasion and migration of ccRCC cells, while Netrin‐4 knockdown reversed these effects in ccRCC cell lines. RNA immunoprecipitation (RIP)‐quantitative polymerase chain reaction validated the robust enrichment of Netrin‐4 mRNA in anti‐IGF2BP2 antibody immunoprecipitates. MeRlP showed significantly increased Netrin4 m6A levels after lGF2BP2 overexpression. Moreover, we found that IGF2BP2 recognized and bound to the m6A site within the coding sequence of Netrin‐4, enhancing its mRNA stability. Collectively, these results showed that IGF2BP2 plays a suppressive role in the invasion and migration of ccRCC cells by targeting Netrin‐4 in an m6A‐dependent manner. These findings underscore the potential of IGF2BP2/Netrin‐4 as a promising prognostic biomarker and therapeutic target in patients with ccRCC metastasis.
Decompression Surgery in Elderly Patients with Hemifacial Spasm Refractory to Botulinum Toxin
Authors: Tugend Margaret , Ulane Christina M. , Patel Kevin , Sekula Raymond F. 
Published: May 2024

AbstractBackgroundBotulinum toxin is an effective treatment for hemifacial spasm in elderly patients. However, some patients do not tolerate the side effects and frequency of botulinum toxin treatments.ObjectivesThe purpose of this study was to evaluate the characteristics and outcomes of a cohort of elderly patients referred by neurologists for surgical decompression of the facial nerve following botulinum toxin treatment.MethodsIn a prospective cohort study, logistic regression was used to detect potential predictors of spasm‐freedom after surgical decompression of the facial nerve in elderly patients that received ≤8 and >8 botulinum toxin treatments for hemifacial spasm before surgery. Age, sex, side, preoperative symptom duration, and preoperative botulinum toxin treatment were assessed as potential predictors of spasm‐freedom at last follow‐up.ResultsOf 76 elderly patients with hemifacial spasm treated with botulinum toxin and microvascular decompression, with at least 2‐years of follow‐up (median, 44.5 months), 84.2% were spasm‐free at last follow‐up. Age (P = 0.38), sex (P = 0.59), side (P = 0.15), preoperative symptom duration (P = 0.7), and number of preoperative botulinum toxin treatments (P = 0.3) were not predictors of long‐term spasm‐freedom. Permanent ipsilateral hearing loss was the most frequent complication (3.9%).ConclusionThis study provides evidence that elderly patients can undergo botulinum toxin treatment for hemifacial spasm without compromising their likelihood of achieving spasm‐freedom with future surgical decompression. Therefore, surgical decompression of the facial nerve is an effective therapy for elderly patients with hemifacial spasm refractory to botulinum toxin.
UGC creator's video‐generation and program‐participation decisions in the presence of ad‐revenue‐sharing programs
Authors: Liu Xueyu , Mei Shue , Zhong Weijun 
Published: May 2024

AbstractVideo‐sharing platforms commonly implement ad‐revenue‐sharing programs to incentivize UGC creators. This paper constructs a game‐theoretic model to examine a creator's optimal decisions on video‐generation and program‐participation. Results show that participating in the ad‐revenue‐sharing program is not always beneficial to creators. Creators with small follower sizes and moderate creation efficiency may experience reduced payoff when participating in that program because of the resultant substantial decrease in the promotion effort offered by the platform. Moreover, the ad‐revenue‐sharing program is not always effective in motivating creators to engage in video generation or incentivizing creators to improve the quality of their videos.
Parameter optimization of type II fuzzy sliding mode control for bridge crane systems based on improved grey wolf algorithm
Authors: Sun Zhiqiang , Sun Zhe , Xie Xiangpeng , Sun Zhixin 
Published: May 2024

AbstractBridge cranes are complex nonlinear dynamic systems with underactuated characteristics, making it challenging for controllers to man age the spatial swing of the load effectively. Additionally, uncertainties both within and outside the system adversely impact control performance. To address these issues, a Type‐II fuzzy sliding mode controller has proven effective in enhancing the anti‐swing control performance of the payload. However, due to the intricate parameter adjustment optimization problem and potential challenges in dealing with nonlinearity and uncertainty, especially in complex dynamic systems, this paper proposes a grey wolf algorithm based on a dynamic spiral hunting mechanism. This enhancement endows the algorithm with improved convergence speed and higher robustness, enabling more effective parameter tuning for the second‐order fractional‐order sliding mode controller (FSMC). The proposed algorithm demonstrates superior convergence speed and solution accuracy performance through testing and comparison. Finally, simulation verification under two conditions of the bridge crane system validates the effectiveness of the proposed approach.
A novel MED12 pathogenic variant in a female fetus with facial cleft and cardiac defects identified in the first trimester
Authors: Dai Wei‐Si , Yang Yan‐Dong , Li Dong‐Zhi 
Published: May 2024

AbstractTrio exome sequencing was performed on a female fetus with an increased nuchal translucency, along with nasal bone hypoplasia, suspected cleft palate and abnormal outflow tract of the heart. A de novo heterozygous variant c.5500_5507del, p.(Tyr1834Argfs × 58) in the MED12 gene was detected. Loss‐of‐function variants in MED12 in females are associated with Hardikar syndrome (HS). A follow‐up ultrasound at 15+5 weeks of gestation identified multiple fetal anomalies including bilateral cleft lip and palate, diaphragmatic hernia, atrioventricular septal defect, persistent truncus arteriosus, and bilateral renal pelvis dilation. Fetal autopsy confirmed the prenatal sonographic findings, and the MED12 variant was discussed by our multidisciplinary team to be the cause of fetal anomalies. Our case is the first prenatal one in which HS was diagnosed due to first trimester structural malformations. This case report presents another example of early identification of a major anomaly which allows earlier genetic diagnosis and more time for clinical management.
Lower peripheral blood CD4+ lymphocyte ratio is associated with severe bronchopulmonary dysplasia
Authors: Huang Jieting , Xing Guosheng , Kong Xiangyong 
Published: May 2024

AbstractObjectiveTo elucidate the characteristics of lymphocyte subsets in bronchopulmonary dysplasia (BPD) diagnosis following Jensen's criterion to understand the spectrum of lymphocytes in different degrees of BPD.Study DesignThis single‐center retrospective cohort study included 120 neonates admitted to the neonatal intensive care unit between 1 July 2014 and 30 June 2021, who had undergone peripheral blood lymphocyte subpopulation detection.ResultsThirty‐one neonates were included in the control group, whereas 33 infants with BPD were included in the case group. In addition, we selected 56 infants with a gestational age (GA) <37 weeks without BPD who were receiving oxygen therapy. Among the three groups, the B cell and NK cell frequencies were significantly higher and the frequencies of T cells and CD4+ cells were significantly lower in the BPD group. In newborns without BPD, the distribution of T lymphocyte subsets was similar at different GAs. Comparing different degrees of BPD, the patients in the grades 2–3 BPD group had significantly lower percentages of T lymphocytes and CD4+ T cells than those in the other groups. Remarkably, the frequencies of NK cells were significantly higher in patients with grades 2–3 BPD, and the Treg cells slightly increased with BPD severity, although the differences were not significant.ConclusionHealthy neonates had similar ratios of lymphocyte subsets among different GAs; although as the GAs increased, the percentage of lymphocytes increased slightly. Severe BPD was associated with lower CD4+ T cells and higher NK cells. However, whether such changes were the cause or the consequence of BPD has not been determined.
Efficacy of head postural correction program on craniovertebral angle, scapular position, and dominant hand grip strength in forward head posture subjects: A randomized controlled trial
Authors: Elgendy Mohamed Hussein , Ghaffar Marwa Adel Abdel , Sabbahi Samir Ahmed El , Abutaleb Enas El Sayed , Elsayed Salah Eldin B. 
Published: May 2024

AbstractObjectiveForward head posture (FHP) is a common postural disorder that alters shoulder function. This study examined the efficacy of a corrective program involving postural correction exercises (PCEs), scapular stabilization exercises (SSEs), and kinesiotaping (KT) on improving craniovertebral angle (CVA), scapular position, and dominant hand grip strength (HGS) in individuals with FHP.MethodsSixty subjects (8 males and 52 females, 18–40 years old) were randomly allocated into four equal groups: Group A: received PCEs only, Group B: received PCEs and SSEs, Group C: received PCEs and KT, Group D: received PCEs, SSEs and KT. All subjects received treatment for 4 weeks (4 times/week) and postural advice. Outcome measures included cranio‐vertebral angle (CVA), scapular position using Lateral Scapular Slide Test and dominant HGS using a CAMRY dynamometer that were assessed at baseline and 4 weeks post intervention.ResultsComparing all groups post training revealed that there were statistically significant increases (p < 0.05) in all measured variables (CVA, scapular position and dominant HGS) in favor of group (D).ConclusionCombination of PCEs, SSEs and KT interventions has achieved the best gains in terms of CVA, dominant HGS and regaining optimal scapular position in FHP subjects.
Preparation and Application of pH‐Sensitive Protein Nanofibre Membrane Loaded With Alizarin and Curcumin for Meat Preservation
Authors: Cui Haiying , Gao Jie , Khin Myat Noe , Aziz Tariq , Al‐Asmari Fahad , Alamri Abdulhakeem S. , Alhomrani Majid , Lin Lin 
Published: May 2024

ABSTRACTA pH‐sensitive protein fibre membrane was prepared using alizarin (ALI), curcumin (CUR), gelatin, zein and cinnamaldehyde as raw materials, by electrospinning technology. The membrane was developed to detect food deterioration and extend shelf life. It was observed that the addition of CUR significantly enhanced the antioxidant and barrier properties of the membrane. The fibre membrane was responsive to pH with minimal colour alteration in response to humidity (from 20% to 80% relative humidity) and demonstrated excellent reusability along with a low detection limit for ammonia gas. Moreover, it was capable of monitoring low concentrations of bacteria in the headspace. To assess the efficacy of the membrane, a freshness monitoring and preservation study was carried out on pork stored at 4°C for 5 days. The fibre membrane not only prolonged the shelf life of meat but also allowed real‐time monitoring of its freshness. The results highlight the potential application of the prepared nanofibres in the simultaneous monitoring and preservation of meat freshness.
Alkylresorcinol detection and identification in archaeological pottery using ultra‐high‐performance liquid chromatography‐quadrupole/Orbitrap mass spectrometry
Authors: Doliente Jonica Ella , Langer Swen , Dickinson Marc R. , Cubas Miriam , Colonese André C. , Penkman Kirsty , Craig Oliver E. 
Published: May 2024

RationaleAlkylresorcinols (AR) are cereal‐specific biomarkers and have recently been found in archaeological pots. However, their low concentrations and high susceptibility to degradation make them difficult to detect using conventional gas chromatography mass spectrometry (GC/MS). Here we describe the development of a more sensitive liquid chromatography mass spectrometry (LC/MS) method to detect these compounds.MethodA method based on the use of ultra‐high‐performance liquid chromatography (UHPLC) coupled to an Orbitrap mass analyser was established and validated for the detection of low‐concentration ARs in pottery. During the preliminary experiments, UHPLC‐Q/Orbitrap MS (ultra‐high‐performance liquid chromatography‐quadrupole/Orbitrap mass spectrometry) was demonstrated to be more sensitive, and a wide range of AR homologues in cereal extracts were detected, unlike UHPLC‐QTOFMS (ultra‐high‐performance liquid chromatography‐quadrupole time‐of‐flight mass spectrometry) and GC/MS. The developed method was utilised to profile AR homologue distribution in modern cereal samples and reanalyse AR‐containing pots from the archaeological site of Must Farm.ResultsA highly sensitive LC/MS method with a limit of detection (LOD) of 0.02 μg/g and a limit of quantification (LOQ) of 0.06 μg/g was used to profile ARs in five modern cereal grains. The obtained LOD is 250 times lower than that obtained using the conventional GC/MS approach. AR 21:0 was the most abundant homologue in all four Triticum spp.—einkorn, emmer, Khorasan wheat and common wheat. Meanwhile, AR 25:0 was the predominant homologue in barley, potentially enabling differentiation between wheat and barley. The developed LC/MS‐based method was successfully used to analyse ARs extracted from Must Farm potsherds and identified the cereal species most likely processed in the pots—emmer wheat.ConclusionThe described method offers an alternative and more sensitive approach for detecting and identifying ARs in ancient pottery. It has been successfully utilised to detect AR homologues in archaeological samples and discriminate which cereal species—wheat and barley—were processed in the pots.
Sedimentology of a delta formed by agricultural river discharge into a flood‐control reservoir, Iowa
Authors: Streeter Matthew T. , Schilling Keith E. , Stoeffler Thomas , Anderson Elliot 
Published: May 2024

AbstractRiver deltas are ecologically critical landscape components and are responsible as habitats for millions of people, wildlife, and plant communities. Deltas store vast quantities of eroded nutrient‐rich sediment and play a significant role in water quality management through nutrient cycling and storage. Many studies have been conducted in marine and tidal delta environments that characterize the sedimentology and geomorphic characteristics of these relatively young landscapes. However, little work has been completed in even younger inland reservoir deltas. This study characterized the sediments and geomorphology of the growing delta forming at the outlet of the Des Moines River into Red Rock Reservoir in south‐central Iowa and discussed the implications of the lower delta sediment and topographic characteristics in terms of sediment and nutrient storage, and the potential impact of the delta on other hydroecological factors. We found that the ca. 30‐year‐old lower delta is storing up to 60% of the contributing watershed's eroded sediment and total carbon, with total sediment depths of ca. 9 m across the 755‐ha area. Further, we identified two major geomorphic landscape positions within the lower delta that were categorized as distributary channels and delta plains. Sedimentological differences in these microscale landscape positions were identified. Sand content was greater at lowest distributary channel elevations and at the highest plain elevations whereas silt dominated the elevation range between these two extremes. The zone of silt accumulation corresponds to the range in elevation associated with normal lake level management. The silt‐dominated area is regularly inundated and covered with a variety of emergent vegetation and is the zone of critical importance for waterbird habitat and nutrient‐processing capacity.
Organizational sensemaking during curriculum implementation: The dilemma of agency, role of collaboration, and importance of discipline‐specific leadership
Authors: Lowell Benjamin R. , Fogelman Sarah E. , McNeill Katherine L. 
Published: May 2024

AbstractAdopting new instructional materials is an important way to support reform in science education, but implementation can be challenging and complex. Therefore, we conducted a contrasting case study of two middle schools implementing new curricular materials. We conducted semi‐structured interviews with teachers and leaders and collected instructional artifacts and reflections from teachers. Using an organizational sensemaking framework, we investigated the tensions that came up during implementation, the resources leveraged to address those tensions, and resulting instructional and leadership practices. One school focused on implementing the materials with fidelity, relying on networking and past practices, which led to a more traditionalized teaching approach. The other school centered the curricular materials, prioritizing understanding the instructional model and customizing for their students, resulting in more aligned instructional practices. Looking across the two cases highlights three key takeaways. First, we discuss the dilemma of agency, which is how can leaders balance teachers' professional agency with the push for instructional reform, especially when teachers may not fully understand the reform approach. We propose that a focus on understanding the goals of instructional reform might help resolve this dilemma. Second, we discuss the role of collaboration as potentially supporting or inhibiting teacher learning and propose that when teachers collaborate about high quality instructional materials they may be more likely to learn about the reforms inherent in them. Finally, we highlight the importance of discipline‐specific leadership in helping teachers to understand and implement the complexities inherent in new science instructional materials.