bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Evalution of a Direct Colorimetic Method for Determination of Amniotic Phospholipids
Authors: Nishino Eriko , Takagi Tetsu , Okamoto Eisaku , Masuhiro Kazuo , Iwata Itsuko , Mitsuda Nobuaki , Tanizawa Osamu , Yoshida Yukuo , Tagawa Kunio , Fujiwara Futoshi 
Published: August 2010

AbstractEvaluation of amniotic phospholipids, which are a parameter of fetal lung maturation, is important in the management of premature infants. The method available for measuring the lecithin/sphingomyelin (L/S) ratio, which appears to provide an index to fetal lung maturity, is laborious, involving determinations of phospholipids, and so is unsuitable for rapid quantitative measurement of phospholipids in the amniotic fluid in the perinatal period. We developed a simple, sensitive colorimetric assay for phospholipids without their extraction. This assay is based on the fact that phospholipids form stable hydrophobic complexes with Co(SCN)4, Fe(SCN)2‐ and Fe(SCN)3 within about 1 hr.Amniotic fluid samples (n=115) were collected from women with normal and abnormal pregnancies in week 16–41 of pregnancy, and these samples were examined both by thin layer chromatography (TLC) and by our method of phospholipid determination. Good correlations were observed between the L/S ratio determined by TLC and the values obtained by this method. Moreover the distributions of the dipalmitoylphosphatidylcholine(DPPC) content and DPPC/sphingomyelin(SM) ratio were similar to those of the PC content and L/S ratio. This method was proved to be more accurate than other methods such as TLC and the shake test for predicting neonatal RDS.
Plasma Levels of Atrial Natriuretic Peptide during Labour and in Puerperium*
Authors: Wong Eric F. C. , Koh Lim W. , Huang Min‐Huo , Wong Norman L. M. 
Published: August 2010

AbstractAtrial natriuretic peptide (ANP), a new cardiac hormone, has potent natriuretic, diuretic and vaso‐relaxant properties in animals and humans. Plasma ANP levels increased in response to volume expansion, atrial distension or postural change. The present investigation was designed to examine the effect of labour on plasma ANP in normotensive pregnant women. The results show that plasma ANP in pregnant women (n=9) increased significantly in active phase of first stage of labour from 19.5±4.6 pg/ml to 74.5±15.1 pg/ml. The magnitude of the increase in ANP levels in active phase varied among the patients. During and after delivery, plasma ANP decreased in all instances towards control level. The cause for the increase in plasma ANP levels in the active phase remains to be determined.
Non‐Immune Hydrops Fetalis
Authors: Li C. Y. , Lao T. T. 
Published: August 2010

AbstractThis article reviews the various aspects of non‐immune hydrops fetalis, including the historical background, aetiology, clinical presentation, antenatal diagnosis and perinatal management, as well as presenting some data on cases of non‐immune hydrops fetalis treated in the newly established Obstetrics Department of the Chinese University of Hong Kong at the Prince of Wales Hospital.
Non‐Hodgkin's Lymphoma in Pregnancy
Authors: Ba‐Thike Katherine , Oo Nan 
Published: August 2010

AbstractA case of non‐Hodgkin's lymphoma who subsequently became pregnant after 6 courses of chemotherapy is presented. Clinical remission was obtained for 3 months after radiotherapy in pregnancy till relapse occurred in the puerperium. The fetus was exposed to chemotherapy in the first trimester and radiotherapy in the second but no adverse effects have been noted so far (5 months).
Transvaginal Sonographic Assessment of the Endometrium in Spontaneous and Induced Cycles
Authors: Germar‐Martinez  , Okai Takashi , Masuda Haruo , Kawamoto Eizoh , Yano Tetsu , Mizuno Masahiko 
Published: August 2010

AbstractTransvaginal sonography was used and endometrial response patterns of 3 groups of patients (Spontaneous cycles, hMG cycles, and Clomiphene Citrate cycles) were observed based on endometrial characteristics of thickness and texture. All groups demonstrated cyclical changes evident by transvaginal sonography. Clomiphene Citrate cycles showed retardation of endometrial growth during the proliferative phase and delayed endometrial development based on textural patterns. There exists a positive correlation between estrogen levels and endometrial thickness in induced cycles, which is not observed in spontaneous cycles. There were no correlations between hormonal levels of progesterone, FSH and LH, in relation to endometrial characteristics of thickness and texture.
Effect of Prolactin (PRL) on Lipoprotein Lipase (LPL) Activity in the Rat Fetal Liver
Authors: Machida Toshifumi , Taga Michiyoshi , Minaguchi Hiroshi 
Published: August 2010

AbstractIn order to clarify the possible involvement of PRL in the regulation of lipid metabolism, the influence of PRL on the levels of LPL activity in rat fetal liver was investigated. Rat fetuses at 18th day of gestation in one uterine horn were injected with o‐PRL while those in the opposite horn with saline. Forty‐eight hr later, the livers were removed from the fetuses, homogenized, defatted, dried overnight, and further homogenized to the enzyme suspension. The measurement of LPL activity in these suspensions revealed that LPL activity in the fetal liver treated with o‐PRL was significantly higher than that of control. LPL activities in the rat fetal liver gradually increased until the time of birth as the gestation proceeded. These results suggest that PRL may be one of the factors regulating fetal lipid metabolism.
An ADPase‐Like Substance in Placental Extracts
Authors: Matsumoto Takafumi , Sugiyama Youichi , Deguchi Katsumi , Okano Kanemichi 
Published: August 2010

AbstractThe inhibitory effect of human placenta on ADP‐induced platelet aggregation was examined. Placental extracts were purified by chromatography and gel filtration. The eluted fractions were subjected to affinity chromatography with Bestatin AH‐Sepharose to obtain a more purified substance. A substance markedly inhibited platelet aggregation induced by ADP, and also exhibited high placental leucine aminopeptidase (P‐LAP) activity. Preincubation of sample with ADP abolished the platelet aggregatory effect. Thin‐layer chromatography (TLC) analysis revealed that the substance hydrolyzed ADP to AMP.The potent anti‐platelet aggregating activity of placental extracts appears to be due to ADPase‐like action. This action may be one of the controlling factors of hemostasis in fetoplacental circulation.Key words: human placenta, platelet aggregation, leucine aminopeptidase, adenosine diphosphatase (ADPase)
Controlled Ovarian Hyperstimulation for in vitro Fertilization Using Buserelin and Gonadotropin in Patients with Previous Failed Cycles
Authors: Loong E. P. L. , Tam P. P. L. , Chiu T. T. Y. , Chan May Y. M. , Panesar N. S. , Lau J. 
Published: August 2010

AbstractFifteen patients who had had previous unsuccessful in vitro fertilization and embryo transfer (IVF) cycles were treated with intranasal buserelin, a gonadotropin releasing hormone agonist (GnRH‐a), commencing in the mid‐luteal phase prior to ovarian stimulation in the next cycle. The use of buserelin was associated with the suppression of spontaneous luteinizing hormone (LH) surges (nil versus 6), an increase in gonadotropin requirements (27.3 versus 13.7 ampoules), higher serum estradiol peak levels (8,154 versus 4,446 pmol/l 19), more oocytes retrieved (87 versus 20) as well as more embryos being transferred (28 versus 7). In buserelin‐treated cycles, 2 pregnancies resulted but no oocyte was recovered in 2 of the 3 poor responders.
Macroscopic Tuboplasty: Reversal of Female Sterilization
Authors: Gupta I. , Sawhney H. , Mahajan U. 
Published: August 2010

AbstractData is presented regarding 57 women who underwent reversal of sterilization procedure. In the majority (90%), the reason for request for reversal of procedure was loss of male child or more than one child. Thirteen subjects never came back for follow‐up. Out of 39 subjects in whom follow‐up is available for more than 3 months, in 35 (90%) the tubes are patent. There were 25 pregnancies in 21 subjects and incidence of viable pregnancy was 88% with only one ectopic pregnancy (4%). In these 35 cases whose tubes were found to be patent post tuboplasty, 18 had laparoscopic ring application, 16 had abdominal tubal ligation and one had undergone vaginal tubal ligation. Thirteen subjects (62%) conceived within 6 months after reversal. In this series, no loupe or operating microscope was used.
Comparative Study of Combination Chemotherapy of Ovarian Cancer: Cyclophosphamide, Adriamycin and Cisplatin versus 5‐Fluorouracil, Cyclophosphamide and Mitomycin C
Authors: Sawada Masumi , Yamasaki Masato , Urabe Takeshi , Ozaki Masami , Yanagita Takao , Takayama Katsumi , Taki Ichiro 
Published: August 2010

AbstractCAP, a multiple‐drug combination therapy using cyclophosphamide (750 mg/m2), adriamycin (20–30 mg/m2) and cisplatin (50–75 mg/m2), was applied to 69 cases of epithelial ovarian cancer. The results of this therapy were compared with those of FAM (involving 5‐fluorouracil, cyclophosphamide and mitomycin C) in 47 cases of the same cancer, retrospectively. The 5‐year survival rate was 61.6% for cases treated with CAP and 56.3% for cases treated with FAM. All 9 patients at stage Ia treated with CAP are free of disease, however, 3 patients out of 13 at stage la treated with FAM experienced a recurrence of the disease and died. In stage III and IV cases with detectable lesions, a response was observed in 61.3% (19/31) treated with CAP and in 10.5% (2/19) treated with FAM.
The Obstetric Management in Very‐Low‐Birth Weight Infants
Authors: Yang Yuh‐Cheng , Jou Tian‐Jii , Wu Chun‐ Hsien , Wang Kuo‐Gon , Lan Chung‐Chi , Shen Ein‐Yiao 
Published: August 2010

AbstractEighty‐three very‐low‐birth weight (VLBW) infants weighing between 500 g and 1,500 g were studied. The neonatal morbidity and mortality were 86.7% and 18.1%, respectively. Sixty‐six point seven percent (8/12) of the infants weighing under 1,000 g suffered from a periventricular‐intraventricular or intracranial hemorrhage (PVH/IVH) and their mortality rate was 50%. The incidence of PVH/IVH was 52.1%, and the mortality rate was 12.7% when the birth weight was between 1,000 g and 1,500 g. Forty‐nine percent of the PVH/IVH took place on the first day of neonatal life, and 93% developed within 5 days after delivery.Cesarean section neither reduced the incidence of PVH/IVH nor increased the survival rate whether in cephalic or breech presentation. The incidence of PVH/IVH was not affected by type of presentation or the interval between the rupture of membranes and the delivery.Respiratory distress syndrome (RDS) and the requiring of a ventilator for ventilation significantly increased the incidence of PVH/IVH, while a low Apgar score (<3) at 5 minutes did not.
Efficacy of Cefoxitin for the Prevention of Postoperative Infection in Abdominal Hysterectomy
Authors: Sutthijumroon S. , Chandeying V. , Tungphaisal S. 
Published: August 2010

AbstractProphylactic effect of cefoxitin against postoperative infection at a dose of 2 g intravenous (single dose 30 minutes before the operation) was investigated using fever index in patients who underwent the elective, nonradical abdominal hysterectomy. The results obtained are summarized as follows. Total fever index values were 12.9±10.0 degree‐hours in the control group (n=39), 11.3±9.7 degree‐hours in the study group (n=39). There were no statistical significance between both groups. Data from this investigation does not suggest the concept that prophylactic antibiotics are beneficial in the reduction of postoperative infection. The results of this prospective study reflected in unnecessity of antibiotic prophylaxis in abdominal hysterectomy.
The Comparison of the Efficacy among Three Different Nimorazole Regimens in the Treatment of Bacterial Vaginosis
Authors: Chandeying Verapol , Sutthijumroon Sonthit , Tungphaisal Somchai 
Published: August 2010

AbstractThe efficacy of 3 different nimorazole regimens in treating bacterial vaginosis in women was evaluated. The regimens consisted of: Nimorazole 2 g single dose (Group I), 1 g per day for 3 days (Group II), and 1 g per day for 7 days (Group III) orally. In a simple randomized trial of 90 cases (30 cases in each group) with demonstrated clinical bacterial vaginosis on the presence of 3 of 5 of the following signs: (1) Characteristic thin homogenous discharge; (2) vaginal pH>4.5; (3) release of a fishy amine odor from vaginal fluid mixed with 10% KOH; (4) presence of clue cells (usually representing at least 20% of vaginal epithelial cells); and (5) vaginal fluid contains few or no lactobacilli. Cure rates for bacterial vaginosis by nimorazole were 70.0% (21/ 30), 83.3% (25/30), and 90.0% (27/30) in Group I, II, and III, respectively. Thus nimorazole is another effective drug for the treatment of bacterial vaginosis.
Time Series Analysis of Biologically Active Luteinizing Hormone Concentrations during Different Stages of the Menstrual Cycle
Authors: Tennekoon Kamani H. , Lenton Elizabeth A. 
Published: August 2010

AbstractThe biologically active luteinizing hormone concentrations (as measured by testosterone production by mouse Leydig cells in response to LH) were measured in integrated hourly blood samples collected over 24‐hour study periods during different stages of the menstrual cycle from a group of regularly cyclic women. Time series analyses were used to analyse the ultradian rhythms in each individual 24‐hour LH profile. Fast Fourier transform (FFT) showed the presence of several ultradian rhythms with different periodicities (varying from 4.4 to 22 hours) in most of the LH profiles. In some of the LH profiles several ultradian rhythms appeared to co‐exist. The commonest significant rhythm as detected by the FFT had a periodicity of 7–9 hours during both the follicular phase (40% of the subjects) and the mid cycle (50% of the subjects) and a periodicity of 5–7 hours during the luteal phase (44% of the subjects).
The Changing Pattern of Maternal and Neonatal Anemia at Udaipur during 2 Decades in Relation to Poverty, Parity, Prematurity and Vegetarianism
Authors: Sharma Dinesh C. , Pendse Vinaya , Sahay Kalyan , Soni Basanti L. 
Published: August 2010

AbstractThe analysis of blood of 50 nonanaemic (Hb>10g%) and 50 anaemic (Hb<10g%) mothers and of their cords with regard to haemoglobin, iron, iron binding capacity and percent saturation of iron was done. It was found that (A) the severity of anaemia and iron deficiency was much greater in women belonging to poor class, vegetarian families or multigravida, (B) the children born prematurely or to anaemic mothers, poor families, strict vegetarians or multiparous women were at a greater risk of developing anaemia and/or iron deficiency, (C) the severity of anaemia and iron deficiency has decreased in last 2 decades in the population served by Zanana Hospital, Udaipur, (D) vegetarianism may be one of the important causative factor of anaemia in pregnant women of this region and their newborn children, and (E) the incidence of macrocytic or macrocytic hypochromic anaemia in pregnant women has become rare in last 20 years.
Treatment of Severe Pre‐Eclampsia by Acetyl Salicylic Acid
Authors: Toppozada M. , Khowessah M. , Shaala S. , Abd‐Rabbo S. , Zoheir A. 
Published: August 2010

AbstractLow‐dose Aspirin® inhibits thromboxane A2with minimal effects on prostacyclin and induces clinical improvements in pre‐eclampsia. Two groups of pre‐eclamptic women (10 in each) were treated either by low‐dose acetyl salicylic acid (group I) or by conventional therapy (group II). Both groups showed a significant drop in systolic and diastolic blood pressure, a decrease in temperature, edema and albuminuria and an increase in urine volume. These effects were more significant in group I than in group II, except for the diastolic blood pressure. The obstetric progress and perinatal outcome were rather similar in both groups. These data offer a new potential therapeutic measure for the management of severe pre‐eclampsia and call for further evaluation in a larger group of cases.
Studies of Cardiovascular and Arterial Blood Gas Changes during Carbon Dioxide Pneumoperitoneum for Laparoscopic Sterilization under General Anaesthesia versus Local Anaesthesia
Authors: Subba B. , Gupta I. , Singh H. 
Published: August 2010

AbstractThis study was conducted to evaluate the different change in arterial blood gases and cardiovascular system in 50 healthy females during laparoscopic sterilization procedure performed under general or local anaesthesia.Women who had laparoscopic sterilization under local anaesthesia, showed an increase in respiratory rate by 17% in response to hypercarbia produced by carbon dioxide insufflation. Subjects undergoing laparoscopic sterilization under general anaesthesia showed significant rise in pulse rate by 6% and systolic and diastolic blood pressure by 8% and 14%, respectively. Also arterial blood gas analysis showed increase in PaO2 by 22.7% which was highly significant. However, PaCO2, pH and base were maintained within normal limits as compared to the other group done under local anaesthesia, where no changes were observed.
Maternal Mortality in Nigerian Women Aged 35 Years and Above
Authors: Okwerekwu Francis E. O. 
Published: August 2010

AbstractMaternal deaths over a 5‐year period were reviewed retrospectively. The aim was to compare the incidence and causes of maternal deaths and the fetal outcome in women aged 35 years and above with women in the 20–24 age bracket. The classic triad of haemorrhage, sepsis and hypertensive disorders were the major causes of deaths in the 2 groups but were commoner amongst the elderly women. A higher incidence of perinatal mortality was also found in the elderly women's group compared to the younger women's group. Pregnancy and delivery at an advanced age is associated with increased risk and should be prevented by the use of effective contraception.
Solitary Metastatic Ovarian Carcinoma of the Spleen: A Case Report
Authors: Minagawa Yukihisa , Kanamori Yasunobu , Ishihara Hiroshi , Morishita Kaichiro , Kigawa Junzo , Ito Takashi , Maeda Kazuo , Saito Seiichiro 
Published: August 2010

AbstractCarcinomatous metastatic involvement of the spleen usually indicates a widespread malignant disease. Solitary metastatic lesions in the spleen are exceedingly rare. The literature contains fewer than 16 cases. In this paper we report a case of a solitary metastatic lesion of the spleen arising from a serous cystadenocarcinoma of the ovary 5 years after the initial operation. A splenectomy was performed followed by smooth postoperative course.
The Mechanism of Human Placental Urea Transport: A Study Using Placental Brush Border (Microvillous) Membrane Vesicles
Authors: Hisanaga Hiroyasu , Iioka Hideaki , Moriyama Ikuko , Nabuchi Kaoru , Morimoto Keiko , Ichijo Motohiko 
Published: August 2010

AbstractTo elucidate the mechanism of placental amino acid transport, the transport of amino acids into brush border membrane vesicles was investigated using brush border membrane vesicles (BBMV) separated from the human full‐term placenta.

The transport of l‐alanine and l‐glutamine into the brush border membrane vesicles prepared from either early gestational placenta or full‐termed placenta disclosed a typical overshooting phenomenon in the presence of H+ concentration gradient (extravesicular pH > intravesicular pH).
The H+‐dependent overshooting transport of urea into the brush border membrane vesicles disappeared in the presence of H+ ionophore.
The initial velocity of H+ concentration gradient dependent uptake of urea into the brush border membrane vesicles was regulated by the saturation kinetics determined by the concentration of urea. The values of Km and Vmax, calculated as the kinetic parameters of urea transport by reciprocal plotting of the initial velocity of uptake and the concentration of urea, were 10.8 mM and 410 μmol/mg protein/10 sec, respectively.

The above results indicate that a transport system which transports urea in exchange for H+ exists in human full‐term placental microvillous membrane.
A Comparison between Fibreoptic and Catheter‐Tip Bridge Strain Gauge Transducers for Measurement of Intrauterine Pressure in Labour
Authors: Tham K. F. , Arulkumaran S. , Chua S. , Anandakumar C. , Singh P. , Ratnam S. S. 
Published: August 2010

AbstractA new fibreoptic pressure transducer was used to measure uterine activity in labour, and the results were compared with those obtained with the catheter‐tip bridge strain gauge transducer. Readings were obtained from 8 patients in spontaneous labour, and a total of 565 contractions were analysed. When all contractions were analysed the coefficient of variation ranged from 11.24 to 42.74. In 2 patients with vast difference in pressure readings one of the catheters had slipped into the lower uterine segment, when these 2 cases were not considered the coefficient of variation ranged from 11.24 to 21.18. Even in the others there were transient periods lasting 5 to 15 minutes when the pressure difference was greater than 10 mmHg between the 2 catheters. When they were excluded from analysis, along with the 2 cases where one of the catheters was displaced, the coefficient of variation ranged from 9.30 to 16.05. The fibreoptic pressure transducer appears to be a safe, convenient and fairly accurate means of assessing uterine activity. But one must be aware that a catheter giving low readings compared with the initial period soon after insertion may be due to displacement of the transducer tip to the uterine lower segment.
The Value of Cordocentesis in Management of Patients with Severe Preeclampsia
Authors: Hsieh T'sang‐T'ang , Kuo Dong‐Ming , Lo Liang‐Ming , Chiu Tsung‐Hong 
Published: August 2010

AbstractSevere preeclampsia affects placental function and causes fetal compromise. It is necessary to deliver the fetus at an appropriate time in order to minimize fetal mortality and morbidity. Cordocentesis was performed in 9 patients with severe preeclampsia (group 1) and 10 patients with other pregnancy complications (group 2). Intrauterine growth retardation occurred in 5 patients in group 1 and in only one patient in group 2. Blood gas parameters including pH, pO2 and O2 saturation were significantly lower for group 1, while pCO2 was significantly higher, as compared to group 2. For patients in group 1, non‐invasive fetal surveillance successfully identified 5 patients with fetal compromise, who required immediate termination of pregnancy. All 5 of these patients had abnormal fetal blood gas analyses by cordocentesis. Fetal blood gas analysis was abnormal in 2 additional fetuses among the remaining 4 patients who exhibited normal findings by non‐invasive methods of fetal surveillance. These results suggest that cordocentesis is useful in identifying fetal compromise (fetal hypoxia/acidosis) prior to the onset of labor in high‐risk patients, such as preeclampsia associated with intrauterine growth retardation.
Current Concepts of Fetal Therapy
Authors: Kuwabara Yoshinori , Unno Nobuya 
Published: August 2010

AbstractThe development of fetal diagnostic techniques has facilitated the analysis of pathological conditions in abnormal fetuses. This has led to systematic fetal therapy for such diseases as fetal hydronephrosis and fetal struma. In this report, general characteristics and problems of fetal therapy are discussed and several representative diseases that have been treated by surgical and pharmaceutical methods are outlined.
A Rare Neural Tube Defect: A Report of Eight Cases in Pakistan
Authors: Haider Parveen , Jafarey Sadiqua 
Published: August 2010

AbstractIniencephaly is a rare congenital malformation of central nervous system and axial skeleton. Eight cases were seen in the Department of Obstetrics and Gynaecology, Jinnah Post‐Graduate Medical Centre over a 12 month period constituting 0.1% of all deliveries conducted, the estimated frequency being 1: 850 deliveries.The purpose of this paper is to describe our cases and to report several considerations which might influence the antenatal diagnosis of this rare anomaly.