bluuebunny/crossref_metadata_2025_split huggingface dataset:
A solvent-free processed low-temperature tolerant adhesive
Authors: Xie Xiaoming , Jiang Yulian , Yao Xiaoman , Zhang Jiaqi , Zhang Zilin , Huang Taoping , Li Runhan , Chen Yifa , Li Shun-Li , Lan Ya-Qian 
Published: June 2024

AbstractUltra-low temperature resistant adhesive is highly desired yet scarce for material adhesion for the potential usage in Arctic/Antarctic or outer space exploration. Here we develop a solvent-free processed low-temperature tolerant adhesive with excellent adhesion strength and organic solvent stability, wide tolerable temperature range (i.e. −196 to 55 °C), long-lasting adhesion effect ( > 60 days, −196 °C) that exceeds the classic commercial hot melt adhesives. Furthermore, combine experimental results with theoretical calculations, the strong interaction energy between polyoxometalate and polymer is the main factor for the low-temperature tolerant adhesive, possessing enhanced cohesion strength, suppressed polymer crystallization and volumetric contraction. Notably, manufacturing at scale can be easily achieved by the facile scale-up solvent-free processing, showing much potential towards practical application in Arctic/Antarctic or planetary exploration.
Covering assisted intuitionistic fuzzy bi-selection technique for data reduction and its applications
Authors: Saini Rajat , Tiwari Anoop Kumar , Nath Abhigyan , Singh Phool , Maurya S. P. , Shah Mohd Asif 
Published: June 2024

AbstractThe dimension and size of data is growing rapidly with the extensive applications of computer science and lab based engineering in daily life. Due to availability of vagueness, later uncertainty, redundancy, irrelevancy, and noise, which imposes concerns in building effective learning models. Fuzzy rough set and its extensions have been applied to deal with these issues by various data reduction approaches. However, construction of a model that can cope with all these issues simultaneously is always a challenging task. None of the studies till date has addressed all these issues simultaneously. This paper investigates a method based on the notions of intuitionistic fuzzy (IF) and rough sets to avoid these obstacles simultaneously by putting forward an interesting data reduction technique. To accomplish this task, firstly, a novel IF similarity relation is addressed. Secondly, we establish an IF rough set model on the basis of this similarity relation. Thirdly, an IF granular structure is presented by using the established similarity relation and the lower approximation. Next, the mathematical theorems are used to validate the proposed notions. Then, the importance-degree of the IF granules is employed for redundant size elimination. Further, significance-degree-preserved dimensionality reduction is discussed. Hence, simultaneous instance and feature selection for large volume of high-dimensional datasets can be performed to eliminate redundancy and irrelevancy in both dimension and size, where vagueness and later uncertainty are handled with rough and IF sets respectively, whilst noise is tackled with IF granular structure. Thereafter, a comprehensive experiment is carried out over the benchmark datasets to demonstrate the effectiveness of simultaneous feature and data point selection methods. Finally, our proposed methodology aided framework is discussed to enhance the regression performance for IC50 of Antiviral Peptides.
Late Holocene relative sea-level records from coral microatolls in Singapore
Authors: Tan Fangyi , Horton Benjamin P. , Ke Lin , Li Tanghua , Quye-Sawyer Jennifer , Lim Joanne T. Y. , Peng Dongju , Aw Zihan , Wee Shi Jun , Yeo Jing Ying , Haigh Ivan , Wang Xianfeng , Aung Lin Thu , Mitchell Andrew , Sarkawi Gina , Li Xinnan , Tan Nurul Syafiqah , Meltzner Aron J. 
Published: June 2024

AbstractLate Holocene relative sea-level (RSL) data are important to understand the drivers of RSL change, but there is a lack of precise RSL records from the Sunda Shelf. Here, we produced a Late Holocene RSL reconstruction from coral microatolls in Singapore, demonstrating for the first time the utility ofDiploastrea helioporamicroatolls as sea-level indicators. We produced 12 sea-level index points and three marine limiting data with a precision of < ± 0.2 m (2σ) and < ± 26 years uncertainties (95% highest density region). The data show a RSL fall of 0.31 ± 0.18 m between 2.8 and 0.6 thousand years before present (kyr BP), at rates between − 0.1 ± 0.3 and − 0.2 ± 0.7 mm/year. Surface profiles of the fossil coral microatolls suggest fluctuations in the rate of RSL fall: (1) stable between 2.8 and 2.5 kyr BP; (2) rising at ~ 1.8 kyr BP; and (3) stable from 0.8 to 0.6 kyr BP. The microatoll record shows general agreement with published, high-quality RSL data within the Sunda Shelf. Comparison to a suite of glacial isostatic adjustment (GIA) models indicate preference for lower viscosities in the mantle. However, more high quality and precise Late Holocene RSL data are needed to further evaluate the drivers of RSL change in the region and better constrain GIA model parameters.
Modeling CO2 solubility in water using gradient boosting and light gradient boosting machine
Authors: Mahmoudzadeh Atena , Amiri-Ramsheh Behnam , Atashrouz Saeid , Abedi Ali , Abuswer Meftah Ali , Ostadhassan Mehdi , Mohaddespour Ahmad , Hemmati-Sarapardeh Abdolhossein 
Published: June 2024

AbstractThe growing application of carbon dioxide (CO2) in various environmental and energy fields, including carbon capture and storage (CCS) and several CO2-based enhanced oil recovery (EOR) techniques, highlights the importance of studying the phase equilibria of this gas with water. Therefore, accurate prediction of CO2 solubility in water becomes an important thermodynamic property. This study focused on developing two powerful intelligent models, namely gradient boosting (GBoost) and light gradient boosting machine (LightGBM) that predict CO2 solubility in water with high accuracy. The results revealed the outperformance of the GBoost model with root mean square error (RMSE) and determination coefficient (R2) of 0.137 mol/kg and 0.9976, respectively. The trend analysis demonstrated that the developed models were highly capable of detecting the physical trend of CO2 solubility in water across various pressure and temperature ranges. Moreover, the Leverage technique was employed to identify suspected data points as well as the applicability domain of the proposed models. The results showed that less than 5% of the data points were detected as outliers representing the large applicability domain of intelligent models. The outcome of this research provided insight into the potential of intelligent models in predicting solubility of CO2 in pure water.
Practices improvement of building information modeling in the Egyptian construction projects
Authors: Nabil Yasmin , Ibrahim Ahmed H. , Hosny Suad 
Published: June 2024

AbstractReduced Reinforced Concrete Material Waste (RRCMW) in building projects is regarded as a critical issue that must be managed. The main purpose of the research is to illustrate the importance of BIM in construction. Also, it is found that the main objectives of this paper are to study the improvement of practicing BIM in Egypt and, practicing of BIM in construction industry in Egypt is also measured. Two questionnaires survey are conducted. The first questionnaire is to measure the improvement of using BIM during the last 7 years and it is discovered that there is a massive improvement in using BIM in this period. The second questionnaire is to determine the adopting value of BIM in Egyptian projects in order to meet the study objective. So, based on the questionnaire analysis, it is discovered that about 94% of consultants actually practicing BIM in 3D while about 72% of contractors agree with practicing BIM in 3D. Also it is found that about 86% and 78% of consultants actually practicing BIM in 4D and 5D while only about 43% and 40% of contractors agree with practicing BIM 4D and 5D model respectively. Only about 61% and 58% considered that BIM is important in 6D and 7D respectively because it isn’t widely used in Egypt and engineers use BIM up to 5D. As a result, the findings reveal that the number of consultant’s site engineer’s respondents are more than contractors because the usage of BIM is effective in the field of design and consultancy more than using in site and while BIM isn't extensively utilized in Egypt, engineers should be familiar with it because it will be a useful tool in the future. So, the main purpose of this study is to illustrate practicing of BIM in the Egyptian construction projects and study the improvement of using BIM during the last 7 years in Egypt because BIM is considered as an important technology used to reduce waste in construction projects from design stage to construction and operation stage but still not used in Egypt in a wide range till now, so it is very crucial to study this issue. Also, another main objective of this study is to compare the development done in using BIM during the last 8 years to make sure that using BIM in Egypt is going on and developed.
Comparative genomics of Giardia duodenalis sub-assemblage AI beaver (Be-2) and human (WB-C6) strains show remarkable homozygosity, sequence similarity, and conservation of VSP genes
Authors: de Paula Baptista Rodrigo , Tucker Matthew S. , Valente Matthew J. , Srivastava Subodh K. , Chehab Nadya , Li Alison , Shaik Jahangheer S. , Ramirez Juan David , Rosenthal Benjamin M. , Khan Asis 
Published: June 2024

AbstractGiardia duodenalis, a major cause of waterborne infection, infects a wide range of mammalian hosts and is subdivided into eight genetically well-defined assemblages named A through H. However, fragmented genomes and a lack of comparative analysis within and between the assemblages render unclear the molecular mechanisms controlling host specificity and differential disease outcomes. To address this, we generated a near-complete de novo genome of AI assemblage using the Oxford Nanopore platform by sequencing the Be-2 genome. We generated 148,144 long-reads with quality scores of > 7. The final genome assembly consists of only nine contigs with an N50 of 3,045,186 bp. This assembly agrees closely with the assembly of another strain in the AI assemblage (WB-C6). However, a critical difference is that a region previously placed in the five-prime region of Chr5 belongs to Chr4 of Be-2. We find a high degree of conservation in the ploidy, homozygosity, and the presence of cysteine-rich variant-specific surface proteins (VSPs) within the AI assemblage. Our assembly provides a nearly complete genome of a member of the AI assemblage of G. duodenalis, aiding population genomic studies capable of elucidating Giardia transmission, host range, and pathogenicity.
ACLS4 could be a potential therapeutic target for severe acute pancreatitis
Authors: Guo Feng , Lu Yunkun , Du Lijun , Guo Xiuliu , Xie Jinyan , Cai Xiujun 
Published: June 2024

AbstractAcute pancreatitis (AP) is currently among the most prevalent digestive diseases. The pathogenesis of AP remains elusive, and there is no specific treatment. Therefore, identifying novel therapeutic targets is imperative for effective management and prevention of AP. In this study, we conducted a comprehensive transcriptomic analysis of peripheral blood from patients with AP and the pancreatic tissue from a mouse model of AP. Our analyses revealed that mouse model of AP exhibited a higher enrichment of mitogen-activated protein kinase signaling, endocytosis, apoptosis and tight junction pathways than the control. Subsequent weighted gene co-expression network analysis identified 15 gene modules, containing between 50 and 1000 genes each, which demonstrated significant correlations within samples from patients with AP. Further screening identified four genes (ACSL4, GALNT3, WSB1, and IL1R1) that were significantly upregulated in severe acute pancreatitis (SAP) in both human and mouse samples. In mouse models of SAP, ACSL4 was significantly upregulated in the pancreas, whereas GALNT3, WSB1, and IL1R1 were not. Lastly, we found that a commercially available ACSL4 inhibitor, PRGL493, markedly reduced IL-6 and TNFα expression, alleviated pancreatic edema and necrosis, and diminished the infiltration of inflammatory cells. In conclusion, this study comprehensively depicts the key genes and signaling pathways implicated in AP and suggests the potential of ACSL4 as a novel therapeutic target for SAP. These findings provide valuable insights for further exploration of therapeutic strategies for SAP.
A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID complications
Authors: Prasanth Mani Iyer , Wannigama Dhammika Leshan , Reiersen Angela Michelle , Thitilertdecha Premrutai , Prasansuklab Anchalee , Tencomnao Tewin , Brimson Sirikalaya , Brimson James Michael 
Published: June 2024

AbstractThere have been 774,075,242 cases of COVID-19 and 7,012,986 deaths worldwide as of January 2024. In the early stages of the pandemic, there was an urgent need to reduce the severity of the disease and prevent the need for hospitalization to avoid stress on healthcare systems worldwide. The repurposing of drugs to prevent clinical deterioration of COVID-19 patients was trialed in many studies using many different drugs. Fluvoxamine (an SSRI and sigma-1 receptor agonist) was initially identified to potentially provide beneficial effects in COVID-19-infected patients, preventing clinical deterioration and the need for hospitalization. Fourteen clinical studies have been carried out to date, with seven of those being randomized placebo-controlled studies. This systematic review and meta-analysis covers the literature from the outbreak of SARS-CoV-2 in late 2019 until January 2024. Search terms related to fluvoxamine, such as its trade names and chemical names, along with words related to COVID-19, such as SARS-CoV-2 and coronavirus, were used in literature databases including PubMed, Google Scholar, Scopus, and the ClinicalTrials.gov database from NIH, to identify the trials used in the subsequent analysis. Clinical deterioration and death data were extracted from these studies where available and used in the meta-analysis. A total of 7153 patients were studied across 14 studies (both open-label and double-blind placebo-controlled). 681 out of 3553 (19.17%) in the standard care group and 255 out of 3600 (7.08%) in the fluvoxamine-treated group experienced clinical deterioration. The estimated average log odds ratio was 1.087 (95% CI 0.200 to 1.973), which differed significantly from zero (z = 2.402, p = 0.016). The seven placebo-controlled studies resulted in a log odds ratio of 0.359 (95% CI 0.1111 to 0.5294), which differed significantly from zero (z = 3.103, p = 0.002). The results of this study identified fluvoxamine as effective in preventing clinical deterioration, and subgrouping analysis suggests that earlier treatment with a dose of 200 mg or above provides the best outcomes. We hope the outcomes of this study can help design future studies into respiratory viral infections and potentially improve clinical outcomes.
Evaluation of highway debris flow hazard based on geomorphic evolution theory coupled with material response rate
Authors: He Na , Han Ruze , Hu Guisheng , Yang Zhiquan , Xu Linjuan , Gurkalo Filip 
Published: June 2024

Abstract
Assessments of highway feasibility frequently lack the detailed data and geological information necessary to conduct hazard evaluations of debris flows. This study discusses the processes of debris flow development when regional rainfall meets the critical level required for debris flow initiation. It utilizes geomorphic evolution theory and establishes a regional risk assessment matrix for debris flow by combining information about gullies and source sensitivity. Considering the location relationship between the highway and debris flow gullies, a rapid evaluation method for debris flow risk assessment along the G318 highway in Sichuan Province is proposed by modifying the judgment matrix. The four debris flow gullies constructed during the upgrading project in Yajiang County, stretching from the west of the city to the Shearer Bay section, were analyzed via examples. The results show that, among the four selected debris flow gullies, two had medium hazard levels, and two had high hazard levels. The validation results are consistent with the actual results, implying that the evaluation method used in this study is accurate and feasible. This method is suitable for the rapid evaluation of debris flow disaster hazards in the feasibility assessment stage of a highway because it relies on readily available data sources, and the evaluation results are fast and convenient. The highway passes through four debris flow gullies, which directly impact the alignment of this particular section of the geological route and the engineering layout. Based on current specifications, the maximum impact range of a one-time debris flow under the given frequency conditions was calculated using the "rainfall method." The results showed that the maximum impact ranges of a debris flow, occurring once in 100 years, for four gullies would be 9.08 m, 9.09 m, 10.86 m, and 10.08 m. The safe clearance heights of bridges over the four gullies should be 14.58 m, 14.59 m, 16.36 m, and 16.3 m. Additionally, the safety clearance width for all gullies should be 5.0 m.
Temperature dependence of the dielectric function and critical points of monolayer WSe2
Authors: Nguyen Xuan Au , Le Long V. , Kim Suk Hyun , Kim Young Duck , Diware Mangesh S. , Kim Tae Jung , Kim Young Dong 
Published: June 2024

AbstractMonolayer materials typically display intriguing temperature-dependent dielectric and optical properties, which are crucial for improving the structure and functionality of associated devices. Due to its unique photoelectric capabilities, monolayer WSe2 has recently received a lot of attention in the fields of atomically thin electronics and optoelectronics. In this work, we focus on the evolution of the temperature-dependent dielectric function (ε = ε1 + i ε2) of monolayer WSe2 over energies from 0.74 to 6.40 eV and temperatures from 40 to 350 K. We analyze the second derivatives of ε with respect to energy to accurately locate the critical points (CP). The dependence of the observed CP energies on temperature is consistent with the alternative domination of the declining exciton binding energy as the temperature increases.
Impact of hyperglycemia on tuberculosis treatment outcomes: a cohort study
Authors: Yanqiu Xu , Yang Yang , Xiaoqing Wu , Zhixuan Lei , Kuan Zhao , Xin Guo , Bo Zhang , Jinyu Wang , Jing Cai , Yan Ma , Aiguo Ma 
Published: June 2024

AbstractHyperglycemia is prevalent and closely associated with pulmonary tuberculosis (PTB). This study aimed to investigate the effects of hyperglycemia on the outcomes of PTB treatment. This study comprised 791 patients with PTB in total. Patients with fasting plasma glucose levels of ≥ 6.1 mmol/L were diagnosed with hyperglycemia. Anthropometric and baseline demographic data were also collected. The treatment response was assessed based on clinical symptoms (sputum production, cough, chest pain, fever, hemoptysis, night sweats, loss of appetite, and fatigue), sputum smear, chest computed tomography (CT), and adverse gastrointestinal responses (vomiting, nausea, abdominal distension, diarrhea, and constipation). A generalized estimating equation (GEE) was used to evaluate these relationships. Hyperglycemia affected 266 (33.6%) of the 791 patients with PTB. In GEE analyses, patients with hyperglycemia exhibited a greater incidence of elevated tuberculosis (TB) scores (odds ratio (OR) 1.569; 95% CI 1.040–2.369), cough (OR 1.332; 95% CI 1.050–1.690), and night sweats (OR 1.694; 95% CI 1.288–2.335). Hyperglycemia was linked with a higher risk of positive sputum smears (OR 1.941; 95% CI 1.382–2.727). During therapy, hyperglycemia was also associated with an increased incidence of vomiting (OR 2.738; 95% CI 1.041–7.198), abdominal distension (OR 2.230; 95% CI 1.193–4.171), and constipation (OR 2.372; 95% CI 1.442–3.902). However, the CT results indicated that hyperglycemia did not affect pulmonary lesions in patients with TB. Patients with TB and hyperglycemia are at a higher risk of severe clinical manifestations, positive sputum smears, and adverse gastrointestinal effects and, therefore, the special situation of hyperglycemic patients should be considered in the prevention and treatment of TB.
Conserved epigenetic hallmarks of T cell aging during immunity and malignancy
Authors: Mi Tian , Soerens Andrew G. , Alli Shanta , Kang Tae Gun , Vasandan Anoop Babu , Wang Zhaoming , Vezys Vaiva , Kimura Shunsuke , Iacobucci Ilaria , Baylin Stephen B. , Jones Peter A. , Hiner Christopher , Mueller April , Goldstein Harris , Mullighan Charles G. , Zebley Caitlin C. , Masopust David , Youngblood Ben 
Published: June 2024

AbstractChronological aging correlates with epigenetic modifications at specific loci, calibrated to species lifespan. Such ‘epigenetic clocks’ appear conserved among mammals, but whether they are cell autonomous and restricted by maximal organismal lifespan remains unknown. We used a multilifetime murine model of repeat vaccination and memory T cell transplantation to test whether epigenetic aging tracks with cellular replication and if such clocks continue ‘counting’ beyond species lifespan. Here we found that memory T cell epigenetic clocks tick independently of host age and continue through four lifetimes. Instead of recording chronological time, T cells recorded proliferative experience through modification of cell cycle regulatory genes. Applying this epigenetic profile across a range of human T cell contexts, we found that naive T cells appeared ‘young’ regardless of organism age, while in pediatric patients, T cell acute lymphoblastic leukemia appeared to have epigenetically aged for up to 200 years. Thus, T cell epigenetic clocks measure replicative history and can continue to accumulate well-beyond organismal lifespan.
The transcription factor PAX5 activates human LINE1 retrotransposons to induce cellular senescence
Authors: Tang Huanyin , Yang Jiaqing , Xu Junhao , Zhang Weina , Geng Anke , Jiang Ying , Mao Zhiyong 
Published: June 2024

AbstractAs a hallmark of senescent cells, the derepression of Long Interspersed Elements 1 (LINE1) transcription results in accumulated LINE1 cDNA, which triggers the secretion of the senescence-associated secretory phenotype (SASP) and paracrine senescence in a cGAS-STING pathway-dependent manner. However, transcription factors that govern senescence-associated LINE1 reactivation remain ill-defined. Here, we predict several transcription factors that bind to human LINE1 elements to regulate their transcription by analyzing the conserved binding motifs in the 5’-untranslated regions (UTR) of the commonly upregulated LINE1 elements in different types of senescent cells. Further analysis reveals that PAX5 directly binds to LINE1 5’-UTR and the binding is enhanced in senescent cells. The enrichment of PAX5 at the 5’-UTR promotes cellular senescence and SASP by activating LINE1. We also demonstrate that the longevity gene SIRT6 suppresses PAX5 transcription by directly binding to the PAX5 promoter, and overexpressing PAX5 abrogates the suppressive effect of SIRT6 on stress-dependent cellular senescence. Our work suggests that PAX5 could serve as a potential target for drug development aiming to suppress LINE1 activation and treat senescence-associated diseases.