bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formation Evaluation Using LWD NMR, LWD Electrical Imaging and Triple Combo Data - A Case Study from India
Authors: Pawandeep Singh Bagga , Harsh Vardhan 
Published: April 2024

Abstract
Logging While Drilling (LWD) Nuclear Magnetic Resonance (NMR), LWD Electrical Imaging along with Conventional Triple Combo LWD services were deployed in Mumbai Offshore field in India. LWD NMR data gives a rock independent porosity measurement which seem to verify the other measurements which in turn increases the data confidence. Depending on rock quality and wettability NMR data might give some good insight in fluid saturations. Furthermore, NMR data gives a permeability Index (also while drilling) which can be useful for selecting pressure stations while drilling, it might also be useful for completion design and production/injection rate calculations. LWD Electrical Imaging tool from provides detailed reservoir characterization, structural classification, and wellbore integrity management in Realtime.
In this well, The NMR permeability seemed to be related to total porosity; high porosity gave high permeability and low porosity gave low permeability, i.e., a synthetic perm curve based on Neutron density aligned quite well with NMR perm. The Hydrocarbon saturation appeared to be highest in the upper part of the section but both Archie saturation and NMR saturation indicate a nearly monotonically decreasing Hydrocarbon saturation towards end of well. In the upper part the T2 peak was positioned at around 1000ms but gradually moved towards a shorter T2 time with depth. Towards bottom the T2 peak had moved down to about 2-300ms and water saturation appeared to be high.
Electrical imaging was used to demarcate the bed boundaries, Dip Picking and Fracture identification. Quick-Look Interpretation of the image data provides evidence of vuggy carbonaceous formation with presence of continuous conductive fractures scattered across the drilled interval. This made the use of permeability model and saturation calculation more complicated. The conventional triple combo helped to steer the well and be in the zone of interest.
The paper in depth discusses the deployments of LWD NMR and LWD Electrical Imaging in the field, Associated challenges, and value these services brought to the operator.
Research of a New Micro-Nano Oil-Displacement System Conformance Control Technology and its Performance Evaluation
Authors: Sun Zhe , Zhang Jian , Wang Xiujun , Huang Bo , Xie Kun , Vasilevskaya Valentina V. , Ushakova Alexandra 
Published: April 2024

Abstract
Although polymer flooding technology has been widely applied and achieved remarkable effect of oil increment. Yet the "entry profile inversion" phenomenon occurs inevitably in its later stage. This exposes the shortcomings of its oil displacement mechanism and ultimately affects the oil recovery rate. Therefore, a novel dispersion system has been developed in recent years. Due to its excellent performance and advanced mechanism, it can effectively overcoming the above issues.
The dispersion system consists of microgel particles and its carrier fluid. After coming into porous media, it shows the motion feature of "trapping, deformation, migration". In this paper, the preparation method, reservoir adaptability evaluation, and plugging and deformation characteristics of dispersion system is firstly studied. Then, by adopting the microfluidic technology, its oil displacement mechanism is further explored. On this basis, oil displacement evaluation is carried out through the CT technology. Furthermore, the typical field application case is analyzed.
Results show that, the dispersion system have good physical and chemical properties performance and transport ability in porous media. Through microfluidic experiments, the temporary plugging and deformation characteristics of microgel particles in the pore throat are clearly displayed. Additionally, due to the partitioning and cooperation between microgels and carrier fluids, the dispersion system causes no damage to the low permeability layer. Furthermore, microgel particles presents the movement feature of "migration, trapping, and deformation" in the porous media, which can realize deep fluid diversion and expand swept volume. 3D macro physical simulation experiment shows that, dispersion system can achieve the goal of enhance oil recovery. Finally, the dispersion flooding technology has been applied in 15 different oilfields, which all obtained great success.
Through interdisciplinary innovative research methods, the oil displacement mechanism and field application of dispersion system is researched, which proves its progressiveness and superiority. The research results provide theoretical basis and technical support for the enhancing oil recovery significantly.
The effect of different constant temperatures on biological characteristics and life table parameters of Trichogramma bourarachae Pintureau and Babault, 1988 (Hymenoptera: Trichogrammatidae)
Authors: Zouba Anis , ZOUGARI Sahar , Latifian Masoud , Mamay Mehmet , Kadri Nabila , Hmida Foued Ben 
Published: April 2024

Abstract

Trichogramma parasitoids are highly effective biocontrol agents largely used in integrated pest management strategies for controlling lepidopterous pests. One of the key factors significantly influencing their efficacy is climatic conditions, with temperature playing a central role. Trichogramma bourarachae Pintureau and Babault (Hymenoptera: Trichogrammatidae), an arrhenotokous parasitoid commonly found in the Mediterranean region, has shown remarkable performance in managing numerous economically important lepidopterous pests. Understanding its thermal requirements holds paramount importance for optimizing rearing techniques and strategic inundative releases. In this study, we investigated the biological characteristics and life table parameters of T. bourarachae at eight constant temperatures (15, 20, 25, 30, 32, 35, 37 and 40°C) using Ephestia kuehniella Zeller (Lepidoptera: Pyralidae) eggs. Temperature had a significant impact on all the key life history traits of T. bourarachae, including the number of parasitized eggs, development time, emergence rate, sex ratio, progeny's longevity, and fecundity. T. bourarachae demonstrates the ability to thrive within a temperature range of 15°C to 37°C, with its optimal development and reproductive performance occurring at 32°C. Life table analysis revealed that the net reproductive rate (R0) and intrinsic rate of increase (r) peaked at 32°C. The finite rate of increase (λ) showed a positive correlation with temperature within the range of 15°C to 32°C. Generation time (T) and doubling time (DT) decreased with increasing temperature from 15°C to 37°C. These results indicate that T. bourarachae is well-adapted to high temperature conditions, positioning it as a promising candidate for controlling thermophilic lepidopteran pests in the Mediterranean region.
Note On Importance of Correct Stoichiometric Assumptions for Modeling of Monoclonal Antibodies
Authors: Gibiansky Leonid , Gibiansky Ekaterina 
Published: April 2024

Abstract

Pharmacokinetic modeling of monoclonal antibodies (mAbs) with non-linear binding is based on equations of the target-mediated drug disposition (Mager and Jusko, 2001). These equations demonstrated their utility in countless examples and drug development programs. The model assumes that the mAb drug and the target have only one binding site each while, in reality, most antibodies have two binding sites. Thus, the currently used model does not correspond to the biological process that it aims to describe. The correct mechanistic model should take into account both binding sites. We investigated, using simulations, whether this discrepancy is important and when it is advisable to use a model with correct stoichiometric 2-to-1 ratio. We show that for soluble targets when elimination rate of the drug-target complex is comparable with the elimination rate of the drug or lower, and when measurements of both total drug and total target concentrations are available, the model with 1-to-1 (monovalent) binding cannot describe data simulated from the model with 2-to-1 (bivalent) binding. In these cases, models with correct stoichiometric assumptions may be necessary for an adequate description of the observed data. Also, a model with allosteric binding that encompasses both 2-to-1 and 1-to-1 binding models as particular cases was proposed and applied. It was shown to be identifiable given the detailed concentration data of total drug and total target.
Effects of The Self- Determined Learning Model of Instruction on Goal Attainment and Self-Determination for Students with Autism Spectrum Disorder Attending College
Authors: Monaghan Meredith Moates 
Published: April 2024

Abstract

PURPOSE
This was the first study to examine the effects of the Self-Determined Learning Model of Instruction (SDLMI) on goal attainment of academic college coursework for students with autism spectrum disorder (ASD). The intervention was designed to facilitate student development, and participation in community college course settings, increase academic and vocational goal attainment and self-determined behavior, while decreasing support needs. The SDLMI has shown to be effective for teaching students with disabilities how to access the general education curriculum and increase self-determination skills to achieve academic goals.
METHODS
A multiple probe design across participants with four college-aged students with ASD, evaluated the effects of the intervention for three different post-secondary education (PSE) goals to show the extent to which the intervention affects participants’ ability to be more self-determined in their decision-making regarding the management of educational goals and course requirements using self-directed learning. The SDLMI Teacher’s Guide for Model Implementation was used for intervention implementation fidelity.
RESULTS
The study compared real time data in point-by-point agreement ratios to quantify the number of times the observers agreed in each observation to determine differences during data collection. The baseline, intervention, and maintenance sessions lasted 1 semester, and data were collected during all sessions. Results from the intervention effects showed a functional relationship (cause-effect) between the intervention and goal attainment.
CONCLUSION
Participants increased their ability to use self-determined behaviors to attain goals through student questions, teacher objectives, and educational supports. Self-determined behaviors increased while support needs greatly decreased.
Consistency of Heat Stress Tolerance Across Life Stages in Macrocystis pyrifera
Authors: Harden Maddelyn , Kovalev Maxim , Molano Gary , Yorke Christie , Miller Robert , Reed Daniel C. , Alberto Filipe , Koos David S. , Lansford Rusty , Nuzhdin Sergey 
Published: April 2024

Abstract

Kelps are vital for marine ecosystems, yet the genetic diversity underlying their capacity to adapt to climate change remains unknown. In this study, we focused on the kelp Macrocystis pyrifera (M. pyrifera), a species critical to coastal habitats. We developed a phenotyping protocol to evaluate heat stress response in 204 M. pyrifera gametophytes, subjected to heat stress treatments ranging from 21°C to 27°C. Here we show that genotypes exhibiting a heat-stress tolerant (HST) phenotype as haploid gametophytes also produced greater biomass as diploid sporophytes in a warm-water ocean farm. This correlation suggests a predictive relationship between early-stage HST and later-stage growth performance, indicating the potential for selecting resilient kelp strains under warmer ocean temperatures. However, HST kelps showed reduced genetic variation, underscoring the importance of integrating heat tolerance genes into a broader genetic pool to maintain the adaptability of kelp populations in the face of climate change.
Quantitative Determination of Residue Amounts of Pesticide Active İngredients Used in Grapes by LC-MS/MS and GC-MS/MS Devices and Evaluation of These Pesticides in Terms of Public Health
Authors: Elmastaş Ayhan 
Published: April 2024

Abstract

The aim of this study was to quantitatively determine pesticide residues in grapes, one of the most produced and consumed fruits in Turkey and in the world. A total of 226 active ingredients were analyzed in 21 samples collected from Southeastern and Eastern Anatolia regions using QuEChERS (quick, easy, cheap, effective, rugged and safe) extraction method and multiple residue analysis technique and LC-MS/MS and GC-MS/MS devices. In 11 out of 21 samples (52.4%), no active ingredient was detected, while at least one active ingredient was detected in 10 samples (47.6%). Thirteen different active substances (Ametoctradin, Azoxystrobin, Boscalid, Diphenoconazole, Dimethomorph, Fenhexamid, Fluopyram, Flutriafol, Metalaxyl- Metalaxyl-M, Metrafenone, Tebuconazole, Trifloxystrobin) were detected in the samples. The top 3 most detected active substances were Boscalid-Azoxystrobin and Fluopyram, respectively. The active ingredients were found between 0.015–0.499 mg.kğ−1 values.
Microbiota and pulmonary hypertension: a systematic review on human studies
Authors: Yarmohammadi Hossein , Soltanipur Masood , Rezaei Mahdi , Soroush Erfan , Mahalleh Mehrdad , Razavi Alireza , Raei Maedeh , Yaghmaei Hessam , Mirhosseini Seyed Mohsen , Siadat Seyed Davar 
Published: April 2024

Abstract

Background
Pulmonary hypertension (PH) is accompanied by unfavorable outcomes and the search for new targets such as metabolites for its treatment is ongoing, therefore, this systematic review gathered evidence of the possible relationship between microbiota and PH.
Methods
This study was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). Population characteristics, PH etiology, treatment, and, severity, and the source of samples were extracted for each study. Also, microbiome composition and increased or decreased bacteria in metabolites were gathered. The quality assessment was performed based on the Joanna Briggs Institute (JBI) checklist.
Results
Eight case-controls were included which all were focused on etiologies other than the left heart diseases. The range of mean values for mPAP of PH patients was 38 to 78 mmHg. Oronasopharynx and bronchoalveolar lavage fluid were the sources of samples in two and one studies respectively. The abundance of different bacteria such as Firmicutes, Hemophilus, Prevotella, and, Bacteroides was altered among PH patients compared to controls. In one study TMAO level was significantly increased among patients with higher REVEAL scores. In five studies random forest modeling was employed to differentiate PH patients from controls and the range of accuracy reported by three studies was 80.3–93.8%.
Conclusion
There is limited evidence regarding the role of microbiome alterations in PH. Both gut and respiratory dysbiosis might play a role in PH pathogenesis and be related to its severity. Clinical trials are needed to investigate the efficacy of probiotics in the treatment of PH.
Investigating Outcomes and Associated Risk Factors of Heterotopic Pregnancy Following In Vitro Fertilization-Embryo Transfer Cycles
Authors: Gao Mingxia , Dong Xianghua , Liu Haifei , Zhou Xinyue , Liu Jiajia , Li Hongwei , Zhang Xuehong 
Published: April 2024

Abstract

Research Question:
To study the outcome of heterotopic pregnancy (HP) and related influencing factors after in vitro fertilization-embryo transfer (IVF-ET), and to provide clinical experience for the treatment of heterotopic pregnancy.
Design:
Observational study.
Results
Our data revealed a HP incidence of 1.27‰. Among the 66 patients with HP, 5 underwent conservative treatment (7.58%, 5/66) with a live birth rate of 25.00% (1/5). Laparoscopic surgery was performed on 61 cases (92.42%, 61/66), with a live birth rate of 77.05% (47/61). ​Further logistic regression analysis revealed that the average diameter of the intrauterine gestational sac prior to laparoscopic surgery, the absence of a fetal germ and fetal heartbeat within the intrauterine gestational sac, and an extended duration of laparoscopic surgery were risk factors affecting pregnancy outcomes (P < 0.05).
Conclusion
Laparoscopic surgery is an effective method for the treatment of HP, and laparoscopic ectopic resection of ectopic pregnancy lesion does not seem to affect the continuous pregnancy and live birth of the intrauterine gestational sac. The mean diameter of the intrauterine gestational sac on the day of surgery, the development of the intrauterine gestational sac, and the duration of surgery can affect the patient's pregnancy outcome.
Emergent inductance and capacitance in elemental tellurium
Authors: Enderlein Carsten , de Oliveira Jaime Ferreira , Fontes Magda , Baggio-Saitovich Elisa , Muller Matheus , Rowley Stephen , Cernicchiaro Geraldo , Lopes Pedro , Neto Marcello Silva 
Published: April 2024

Abstract
The miniaturisation of electronic building blocks is of uttermost importance. Efficient nanoscopic inductors and capacitors could pave the way to better energy economics and therewith more powerful processors. Topological materials which exhibit emergent electromagnetism are promising candidates for such future technologies. Due to its helical crystal structure and strong spin-orbit interaction, tellurium exhibits an experimentally verified internal inductance. By formulating the constitutive equations which describe electromagnetism in tellurium, we show how capacitive and inductive properties naturally emerge in the material. We demonstrate on the basis of AC-impedance measurements that elemental tellurium exhibits an unusually high virtual capacitance and inductance, far exceeding previously studied materials. The highest capacitance we detect in our samples is 130 mF and in one of our samples we measure an extremely impressive virtual inductance of 1.5 H. For low current densities a single piece of tellurium mimics the reactance of an RLC-circuit.
Accuracy of CBCT with different fields of view and voxel sizes for detection of simulated periodontal defects in comparison with periapical radiography: An in vitro study
Authors: Foroozandeh Maryam , Kavandi Sina , Poormoradi Banafsheh , Shokri Abbas , Zohrevand Fatemeh , Cheraghi Fatemeh 
Published: April 2024

Abstract

Objectives
This study aimed to assess the accuracy of different fields of view (FOVs) and voxel sizes of cone-beam computed tomography (CBCT) for detection of simulated periodontal defects in comparison with periapical (PA) radiography.
Materials and Methods
This in vitro study was conducted on 60 periodontal defects including furcation and wall defects, dehiscence, and fenestration that were artificially created in 5 mandibles of freshly slaughtered sheep. After recording the defect sites and types as the gold-standard, they underwent PA radiography. Thirty CBCT images were also obtained in three FOVs and voxel sizes of 13 x 17 cm2/ 300 µm, 10 x 10 cm2/ 180 µm, and 5 x 5 cm2/ 90 µm, and evaluated by a radiologist and a periodontist. The inter-observer agreement was assessed by the kappa coefficient, and the parameters were calculated and compared using the Chi-square test with STATA 14.
Results
The inter-observer agreement was generally 85.4% for all periodontal defects; this value was the highest (88.1%) with the smallest FOV and voxel size (5 x 5 cm2 and 90 µm). By a reduction in FOV and voxel size, the inter-observer agreement significantly increased (P < 0.001). The mean sensitivity, specificity, PPV, and NPV were 87.8%, 94.9%, 94.6%, and 88.4%, respectively, for CBCT. These values for PA radiography were lower than the corresponding values for CBCT.
Conclusion
Sensitivity, specificity, PPV, NPV, and inter-observer agreement increased in use of smaller FOV for detection of simulated periodontal defects, indicating an increase in diagnostic accuracy by a reduction in FOV and voxel size.
The molecular immune modulator adenosine deaminase-1 enhances HIV specific humoral and cellular responses to a native-like HIV envelope trimer DNA vaccine
Authors: Kutzler Michele A. , Cusimano Gina , Joyner David , Konopka Emily , Muir Roshell , Barnette Philip , Guderian Melanie , Moral-Sánchez Iván del , Derking Ronald , Bijl Tom , Snitselaar Jonne , Rotsides Photis , Woloszczuk Kyra , Bell Matthew , Canziani Gabriela , Chaiken Irwin , Hessell Ann , Bartsch Yannic , Sanders Rogier , Haddad Elias 
Published: April 2024

Abstract

There is currently no prophylactic vaccine available for human immunodeficiency virus (HIV). Research efforts have resulted in improved immunogens that mimic the native envelope (Env) glycoprotein structure. Recently, a novel triple tandem trimer (TTT) platform has been used to generate a plasmid encoding Env immunogen (pBG505-TTT) that expresses only as trimers, making it more suitable for nucleic acid vaccines. We have previously demonstrated that adenosine deaminase-1 (ADA-1) is critical to the T follicular helper (TFH) function and improves vaccine immune responses in vivo. In this study, we demonstrate that co-delivery of plasmid-encoded adenosine deaminase 1 (pADA) with pBG505-TTT enhances the magnitude, durability, isotype switching and functionality of HIV-specific antibodies in a dose-sparing manner. Co-delivery of the molecular immune modulator ADA-1 also enhances HIV-specific T cell polyfunctionality, activation, and degranulation as well as memory B cell responses. These data demonstrate that pADA enhances HIV-specific cellular and humoral immunity, making ADA-1 a promising immune modulator for HIV-targeting vaccines.
A concentration-dependent differential AKT phosphorylation regulation between the breast normal and tumor cells induced by the flavonoids in Macrothelypteris torresiana under the combinational administration with a AKT inhibitor
Authors: Ouyang Yi , Wang Lin , Hao Xincai 
Published: April 2024

Abstract

The combinational application of herbal extract with chemical synthetic medicines is a very common therapeutic scheme for various disease. People have explored lots of combinations of natural medicine and chemical synthetic medicines to increase efficacy and reduce side effects in long lasting clinical medication. Our work found that the extract of Macrothelypteris torresiana could interfere with the inhibition of AKT phosphorylation induced by wortmannin in a concentration dependent manner, and the interaction mechanisms were elucidated by concentration-effect analysis and pharmacological evaluation. The study found the interaction is mainly attributed to the competitive inhibition between two flavonoids in the extract of Macrothelypteris torresiana and wortmannin, which competitively bind with the P110 subunit in PI3K complex. The study also found that, due to the hyperphosphorylation in the breast tumor cells, the pharmacological benefits based on the interaction are correlated with the concentration of Macrothelypteris torresiana extract in the combinational administration schemes. The combinational administration with 10 µg/mL EM and 0.5 µM wortmannin, a classic inhibitor of AKT, could down-regulate the AKT phosphorylation level in the tumor cells, meanwhile protecting the normal cells. The finding supports the idea of side effect reduction by combinational administration of low concentration of natural medicine and chemical synthetic medicine.