bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Ovarian Leiomyoma: A Case Report
Authors: Sato Yasumi , Tanaka Tosinobu 
Published: May 2010

AbstractWe present a rare case of a 61‐year‐old Japanese woman with an ovarian leiomyoma. That was detected during a mass screening. To our knowledge, this is the first report of an ovarian leiomyoma found during a mass screening. We performed a total abdominal hysterectomy and a bilateral salpingo‐oophorectomy. The tumor originated in the right ovary, and it did not connect with the uterus. The smooth muscle origin of the tumor was detected by immunohistochemical staining with antibodies to vimentin, desmin, and smooth‐muscle actin (SMA).
Evaluation of Insulin‐Like Growth Factor Binding Protein‐1 as a Diagnostic Tool for Rupture of the Membranes
Authors: Kubota Takeyoshi , Takeuchi Hisaya 
Published: May 2010

AbstractObjective:To evaluate the diagnostic value of insulin‐like growth factor binding protein‐1 (IGFBP‐1) as an indicator of ruptured fetal membranes.Methods:IGFBP‐ 1 concentrations were measured on 42 paired cervicovaginal samples before and after membrane rupture, using an immunoenzymatic assay. A PROM test [dipstick detecting IGFBP‐1 with a cutoff value of 25 μg/l (A)], a BTB test (B), a ROM‐Check (C), and a fern test (D) were compared in diagnosing ruptures of the membranes in 48 patients.Results:The optimal cutoff concentration was between 20.1 μg/l and 148.4 μg/l by receiver operating characteristic curve analysis. The PROM test had the highest sensitivity (94.7%) and highest specificity (93.3%) (sensitivity of A‐D, B‐D, C‐D and specificity of A‐B: p < 0.05 by χ2‐test). Unlike the other tests, the PROM test is unaffected by contamination, cervical dilatation, or uterine contraction.Conclusions:The measurement of IGFBP‐1 in vaginal fluids is useful for the diagnosis of ruptured fetal membranes.
Borderline Tumors of the Ovary: A Clinico‐Pathologic and Immunohistochemical Study of 54 Cases
Authors: Kuhn Walther , Marx Dagmar , Meidel Andre , Fattahi‐Meibodi Arjang , Korabiowska Monika , Ruschenburg Ilka , Droese Manfred , Schauer Alfred , Meden Harald 
Published: May 2010

AbstractObjective:To study EGF‐R, HER‐2/neu (p185), p53, Mib‐1 (Ki‐67), Bax, Bcl‐2, ras expression and ploidy in borderline tumors of the ovary by assessing their frequency, and relationship to histologic type, tumor recurrence and survival.Methods:Fifty‐four patients with borderline tumors were followed 3–140 months (median: 38 months). Paraffin‐embedded sections were stained using monoclonal antibodies against EGF‐R, HER‐2/neu (p185), p53, Mib‐1 (Ki‐67), Bax, Bcl‐2, and ras. The immunohistochemical findings were correlated to histologic subtype, tumor recurrence, and survival.Results:Positivity for EGF‐R was found in 24% (13/54), in 22% (12/54) p185 was positive, 9% (5/54) of tumors were p53‐positive, Mib‐1 (Ki‐67)‐positivity was demonstrable in 46% (25/54). Expression of Bax, Bcl‐2, and ras was found in 37% (20/54), 28% (15/54) and in 7% (4/54) of the cases, respectively.Conclusion:The data demonstrate expression of EGF‐R, p185/HER‐2/neu, p53, Mib‐1 (Ki‐67), Bax, Bcl‐2, and ras in a subgroup of patients with ovarian borderline tumors. Further studies to evaluate their prognostic value are warranted.
Operative Results after Primary and Secondary Debulking‐Operations in Advanced Ovarian Cancer (AOC)
Authors: Lichtenegger Werner , Sehouli Jalid , Buchmann Erhardt , Karajanev Constanza , Weidemann Henning 
Published: May 2010

AbstractObjective:To assess the role of primary and secondary radical surgery in advanced ovarian cancer (AOC).Design: Retrospective study.Methods:One handred and fifty‐one patients with AOC (FIGO III/IV) underwent altogether 191 extended multivisceral operations between 1/1992 and 2/1998. The statistic analysis compared the primary with the secondary operations.Results:One hundred and seventeen patients had a primary, 63 patients had a secondary and 18 patients a tertiary operation because of relapse of ovarian cancer. Surgical procedures entailed respectively: small‐bowel‐resection (21%/48%), colon resection (39%/58%), colostomy (9%/ll%), ileostomy (2%/4%), ileum‐pouch (0%/6), splenectomy (3%/3%), pelvic floor‐covering (4%/6%), peritoneal removal (24%/21%), infrared contact coagulation (4%/6%). Seventy‐five percent of the patients had no complications: relaparotomy (3%/3%), fistula (3%/6%), short‐bowel‐syndrome (5%/ 11%), postoperatively mortality (2%/6%). Postoperative tumor‐free were 26%/22%, 57% and 65% had residual disease ≤ 2 cm, 16%/13% > 2 cm.Conclusions:Radical multivisceral surgery is feasible, safe and efficient in primary as well in secondary situation of advanced ovarian cancer.
Elective Induction of Labor at 39 Weeks of Gestation: A Prospective Randomized Trial
Authors: Amano Kan , Saito Katsu , Shoda Takashi , Tani Akihiro , Yoshihara Hajime , Nishijima Masahiro 
Published: May 2010

AbstractObjective: To clarify the safety of elective induction of labor at 39 weeks of gestation.Study design: Prospective randomized study.Subjects and methods: Uncomplicated nulliparas (N = 194) were randomly assigned at 36 weeks of gestation. Labor was electively induced in 63 women at 39 weeks of gestation in the active management group (I group, N = 98). Spontaneous labor onset was expected with semi‐weekly nonstress test (NST) and amniotic fluid index (AFI) by 42 weeks of gestation in the expectant group (E group, N = 96). Perinatal events were compared between the 2 groups.Results: A significantly higher incidence of meconium‐stained amnios (19.4% vs 3.2%) and fetal resuscitation (16.7% vs 4.8%) was found in the E group than in the 1 group. Also, although a significantly higher incidence of epidural analgesia was noted in the 1 group (89%) than in the E group (54%) (labor onset ≥ 39 weeks, N = 72), the duration of the 1st stage was shorter in 1 group and the duration of the 2nd stage was not significantly different. No other significant difference was noted between the 2 groups in terms of the rate of C‐section, blood loss, incidence of pathological FHR, birth weight, Apgar score, umbilical arterial pH, or admission to NICU.Conclusion: Active management of labor at 39 weeks could be made as safely as expectant management with modified biophysical profile monitoring.
Obstetrical Management Following Incontinence Surgery
Authors: Casper Fritz W. , Linn Jürgen F. , Black Peter 
Published: May 2010

AbstractObjective: To analyze in a retrospective fashion our experiences with obstetrical management following previous incontinence surgery.Methods: Between 1990 and 1997 4 women presented to our institution in the third trimester of pregnancy with a history of colposuspension performed 3 months to 4 years before onset of pregnancy for second degree stress incontinence. Three of 4 patients experienced recurrent incontinence during the third trimester.Results: A cesarean section was performed before the onset of labor in all 4 patients. Postpartal pelvic floor exercises were prescribed and a follow‐up ensued after 6 and 11 months in the form of a questionnaire. While incontinence persisted in 2 patients for 6 months, all 4 patients demonstrated complete continence after one year.Conclusions: We consider an elective cesarean section to be the optimal mode of delivery in women with a history of incontinence surgery.
A Prospective Randomized Study Comparing Hysteroscopy and Curettage (H & C) under Local Anaesthesia (LA) and General Anaesthesia (GA) in Chinese Population
Authors: Kun Ka‐Yan , Lo Leslie , Ho Mei‐Wa , Tai Chark‐Man 
Published: May 2010

AbstractObjective: To compare the difference in patient's acceptance of local anaesthesia (LA) and general anaesthesia (GA) hysteroscopy and curettage in Chinese population.Design: A prospective randomized study.Subjects and methods: In the period September 1994 to August 1995, all Chinese women with abnormal uterine bleeding or suspected uterine anomaly who warranted hysteroscopy and uterine curettage were invited to participate in this study with informed consent. They were randomly allocated to the control (ie. GA) and study (ie. LA) group.Results: Overall 90% of the controls and 91% of the study group were satisfied with the procedure. The hysteroscopic diagnostic accuracy was 83%. Significantly higher percentage of patients in the study group opted for the same form of admission arrangement if given the choice.Conclusion: Hysteroscopy and curettage under LA and GA are equally acceptable in the Chinese population in Hong Kong. The patient satisfaction rate is high in both groups. Hysteroscopic diagnosis is highly accurate in malignant condition (100% sensitivity and 83% specificity).
Rates of Endometriosis Recurrence and Pregnancy 1 Year after Treatment with Intranasal Buserelin Acetate (Suprecur®) (A Prospective Study)
Authors: Mori Hiroyuki , Taketani Yuji , Uemura Tsuguo , Miyake Akira , Tango Toshiro 
Published: May 2010

AbstractObjectives: This multicenter prospective study of buserelin acetate (Suprecurr̀) therapy for endometriosis was performed in order to examine pregnancy rates and the recurrence of endometriosis 1 year after the end of intranasal administration.Methods: This study was conducted at 349 institutions, including university hospitals and major hospitals in Japan, and 1,284 patients were recruited as participants.Recurrence of symptoms was followed for 1 year after the end of administration of buserelin acetate in patients whose condition as a whole was evaluated as “improved” or better at the end of administration. Furthermore, the pregnancy rate was similarly followed in patients who complained of sterility at the commencement of the administration.Recurrence was defined as either a case in which all of the main symptoms observed before administration returned to the pretreatment state, or a case in which at least one symptom deteriorated compared to the pretreatment state.Kaplan‐Meier's method was used for statistical analysis.Results: Among 459 patients who could be evaluated for recurrence of symptoms, the cumulative recurrence rate was 17.8% 1 year after the end of administration. Among 156 patients who could be evaluated for pregnancy, the pregnancy rate was 23.3% 1 year after the end of administration.Conclusion: Intranasal buserelin acetate therapy exhibited not only transient clinical effects during administration or immediately after the end of administration, but also exhibited specific continuing effects after the end of administration.
Survey of Physical Abuse during Pregnancy GMCH, Nagpur, India
Authors: Purwar Manorama B. , Jeyaseelan L. , Varhadpande Urmila , Motghare Vijay , Pimplakute Sonali 
Published: May 2010

AbstractIntroduction: Domestic violence is a major health concern for women globally. Violence may commence or escalate during pregnancy and may be more frequent than obstetric complications e.g. preeclampsia or gestational diabetes for which they are routinely screened. No literature is available on abuse during pregnancy from India.Objective: To assess the frequency and severity of physical abuse during pregnancy and its association with entry to antenatal care and to identify lifetime risk factors.Study Design: Cross sectional study.Study Setting: Secondary and tertiary care public hospital.Participants: Six hundred randomly selected pregnant women in third trimester of pregnancy (28–40 weeks of gestation) attending routine antenatal clinic were assessed for physical abuse using Abuse Assessment Screen (AAS) developed by McFarlane.Main Outcome Measures: Abuse status, gestational age at first antenatal visit and life‐time risk factors.Analysis: Descriptive, Univariate and MLR.Results: Of the 600 pregnant women interviewed, 152 (25.33%) women reported abuse during non pregnant state, 132 (22%) women reported physical abuse during index pregnancy and 10 (8.33%) women reported increase in abuse during pregnancy. In majority the abuse site was head and neck and 20% reported being hit in the abdomen. Abuse was recurrent in 92% of women. Six (4.54%) women were hospitalized, 5 (3.78%) needed medical assistance and 19.7% women were afraid of partner (husband). Abused women were twice as likely to begin antenatal care after 32 weeks of gestation as compared to non abused women (OR = 2.5; 95% CI 1.1–5.6, p = 0.02). Abused women were more likely to be Buddhist (p = 0.005), of greater parity with unwanted pregnancy, dwelling in slums (p = 0.005), from extended family (p = 0.005), with low level of education to husband (p = 0.009) and with stress to husband (p = 0.03).Conclusions: There is significant physical abuse during pregnancy in central India. Routine screen by AAS and a cohort study looking at adverse outcome of pregnancy is recommended.
Optimal Dose of Nalbuphine for Treatment of Intrathecal‐Morphine Induced Pruritus after Caesarean Section
Authors: Somrat Charuluxananan , Oranuch Kyokong , Ketchada Uerpairokit , Siriprapa Singhapreecha , Thipawan Ruangrit 
Published: May 2010

AbstractObjectives: To search for the optimal dosage of nalbuphine relief of intrathecal‐morphine induced pruritus after caesarean section.Methods: Ninety parturients who developed moderate to severe pruritus caused by intrathecal morphine after caesarean section were randomly allocated into 3 groups receiving 2, 3 and 4 mg of intravenous nalbuphine respectively. The improvement of pruritus and adverse effects of nalbuphine such as increasing pain scores, nausea, vomiting, sedation and respiratory depression were evaluated at 15 minutes after nalbuphine administration.Results: Percentage of successful treatment of pruritus with 2, 3 and 4 mg, nalbuphine were 86.7,96.7 and 100, respectively (p = 0.12). There was no statistically significant difference in adverse effects. No evidence of respiratory depression was detected. However, there was significant increase in pain scores in group of 4 mg nalbuphine (p = 0.004).Conclusions: Nalbuphine of 2 to 3 mg was considered to be adequate in treatment of intrathecal morphine induced pruritus after caesarean section without increasing pain scores or causing other side effects.
Sexual Transmission and Reinfection of Group B Streptococci between Spouses
Authors: Yamamoto Tsutomu , Nagasawa Isamu , Nojima Michio , Yoshida Koyo , Kuwabara Yoshinori 
Published: May 2010

AbstractObjectives: To study how GBS infection takes place between pregnant GBS‐carriers and their husbands.Methods: Pregnant women in whom GBS infections could be detected during 26 to 30 weeks of pregnancy and their husbands were studied during the two periods of August 1994 through May 1995 (Period A, 243 couples) and June through September 1997 (Period B, 141 couples). A urine sample was collected from a husband in the same morning when the vagina of his wife was tested for GBS. GBS were also classified according to their serotypes in 34 couples during Period A and B.Results: In the two periods, GBS was detected in 18.1 and 19.3% of the wive's vaginal cultures, and in 19.1 and 17.0% of husbands' urinary cultures, respectively. There were no significant differrences of the rate of GBS detection between the spouses, and also between the two trials. A high possibility of GBS infection was found in a couple when either of the spouses was possible to GBS. The serotypes of 31 of the 34 couples (91.2%) were identical.Conclusion: It is suggested that GBS can be sexually transmitted, and cause reinfection between spouses in spite of antepartum medication.
Morphological Aspects of Ectopia Cordis: Four Case Reports and a Review of the Literature
Authors: Yamada Takahiro , Hoshi Nobuhiko , Okuyama Kazuhiko , Negishi Hiroaki , Sudo Satoko , Kishida Tatsuro , Yamada Hideto , Sagawa Tadashi , Fujii Hiroaki , Ishizu Akihiro , Ishikura Hiroshi , Fujimoto Seiichiro 
Published: May 2010

AbstractEctopia cordis is a rare congenital anomaly. We present 4 cases of ectopia cordis, 1 of which is the first report of an affected fetus in a triplet pregnancy. The morphological relationship between the types of ectopia cordis and their outcomes were investigated in all 4 cases. In addition, the literature on ectopia cordis in Japan was reviewed and discussed.
The Effect of Medroxyprogesterone Acetate and Heparin in the Prevention of Postsurgical Adhesion Formation in the Rat Uterine Model
Authors: Saǧol Sermet , Özşener Serdar , Dinçer Ömer , Yilmaz Hüseyin , Karadadas Nedim 
Published: May 2010

AbstractObjective: To evaluate the effects of depot medroxyprogesterone acetate and heparin in preventing postsurgical adhesion formation in the rat model.Methods: A hundred and five female Wistar rats were divided into 7 groups. Groups 1 and 2 were injected with intramuscular 15 mg medroxyprogesterone acetate 3 weeks before surgery and at the end of laparotomy. Groups 3 and 4 were given 15 mg medroxyprogesterone acetate by intramuscular injection, 3 weeks before surgery. An equal volume of intramuscular sterile saline was injected to control groups, 3 weeks before and at the end of surgery. Before abdominal closure, 2 ml of Ringer's lactate was instilled into the peritoneal cavity of all rats, except group 7. Groups 1, 4, and 5 were given 2 ml of intraperitoneal Ringer's lactate containing 500 U heparin/ml. A standardized surgical injury was performed in all rats. Two weeks after surgery, the adhesions were scored on a scale of 0 to 3 according to their thickness‐tenacity and vascularity. Kruskall‐Wallis and Mann‐Whitney U statistical test were used.Results: The preoperative and postoperative administration of medroxyprogesterone acetate resulted in the least number of and the least severe adhesions, when compared with single dose medroxyprogesterone acetate treated rats and controls (p < 0.05). However, the combination of medroxyprogesterone acetate and intraperitoneal heparin did not enhance the adhesion reducing capacity of medroxyprogesterone acetate.Conclusions: Concurrent preoperative and postoperative administration of medroxy‐progesterone acetate results in the most significant reduction of postsurgical adhesions. The combination treatment of medroxyprogesterone acetate and heparin does not show any additional effect in the reduction of adhesion formation, when compared with medroxyprogesterone acetate treatment alone.
A Case of Primary Transitional Cell Carcinoma of the Fallopian Tube
Authors: Kim Jae Wook , Cho Eun Me , Kim Young Tae , Han Jae Ho 
Published: May 2010

AbstractThe primary carcinoma of the fallopian tube is the rarest of all gynecologic malignancies and histologically most of them are adenocarcinomas. Primary transitional cell carcinomas are extremely rare in the fallopian tube. A 63‐year‐old postmenopausal woman presenting with lower abdominal pain was found to have a left adnexal mass. Exploratory laparotomy revealed a mass arising from the fallopian tube with the histologic features of transitional cell carcinoma. Light and electron microscopic studies supported the notion of transitional cell carcinoma. The tumor was extended to the muscle layer and confined to the left fallopian tube without metastasis. The patient received 3 courses of systemic cisplatin‐based chemotherapy and has been well with no evidence of recurrence until August, 1998.
Effect of Methamphetamine on Male Mice Fertility
Authors: Yamamoto Yoshiko , Yamamoto Keiichi , Hayase Tamaki 
Published: May 2010

AbstractThe effect of methamphetamine (MAMP) on the ability of males to mate with females and to impregnate them was examined in 8‐week‐old ICR mice. Male mice that had been administered an intraperitoneal injection of MAMP (15 mg/kg, 7.5 mg/kg, or 3.75 mg/kg) or saline were housed with females 24 or 48 hours later. The vaginal plugs were checked, and the number of births was counted. The effect of MAMP on sperm motility and the serum testosterone (TS) concentration was also examined.Methamphetamine was observed to have harmful effects only at the highest dose level. In the mice housed 24 hours after the injection of 15 mg/kg MAMP, the increase in the cumulative number of vaginal plugs lagged, and the total number of vaginal plugs decreased significantly. A significant decrease was also observed in the total number of births.Methamphetamine, at a dose of 15 mg/kg, decreased sperm motility. The TS concentration decreased initially, then increased.
Recent Trends in Histological Pattern of Cervical Carcinoma among Three Ethnic Groups in Malaysia*
Authors: Cheah Phaik‐Leng , Looi Lai‐Meng , Sivanesaratnam Vallipuram 
Published: May 2010

AbstractObjective: To study the trend of different histological types of cervical carcinoma among the 3 major ethnic groups in Malaysia.Methods: All invasive cervical carcinoma histologically diagnosed for the first time in 1991–1992 and 1996–1997 at the University Hospital, Kuala Lumpur (UHKL) were reviewed for the following parameters; age, ethnic group, histological category.Results: One hundred and twenty‐one and 145 cases were diagnosed in 1991–1992 and 1996–1997, respectively. During both periods, squamous was followed by adeno and adenosquamous carcinoma in frequency. Patients' mean ages ranged within the 4th decade for all 3 major histological types. Ethnically, an overall predilection for the Chinese was observed. While squamous carcinomas had declined among the Chinese and Malays, adenocarcinomas were noted to increase. The converse was observed among the Indians.Conclusions: Ethnically, cervical carcinoma showed a predilection for Malaysians of Chinese descent. A decreasing incidence of squamous with a worrying increasing trend of adenocarcinoma was observed, like in other populations studied.
Brain Natriuretic Peptide (BNP) and Cyclic Guanosine Monophosphate (cGMP) Levels in Normal Pregnancy and Preeclampsia
Authors: Okuno Suzuka , Hamada Hiromi , Yasuoka Mana , Watanabe Hideki , Fujiki Yutaka , Yamada Naoki , Sohda Satoshi , Kubo Takeshi 
Published: May 2010

AbstractObjective: Our purpose was to evaluate plasma levels of brain natriuretic peptide (pBNP) and cyclic guanosine monophosphate (pcGMP) in preeclamptic patients and controls.Study Design: Blood samples were obtained from 35 patients with preeclampsia and from the same women during the subsequent puerperal period. The control group consisted of normotensive pregnant women, matched with the patients for age, gestational age, and parity. The concentrations of pBNP and pcGMP were determined by the RIA method. Statistical analysis was performed using the Mann‐Whitney's U test.Results: The pBNP level in the preeclampsia group was significantly increased, to 7‐fold that of the control group. The pcGMP level was 50% higher in the preeclampsia group than in the control group, but this was not significant. Both the pBNP level and the pcGMP level in the puerperal period did not significantly differ between the patients and the controls.Conclusion: The pBNP concentrations increased in the preeclamptic women, and then these compensations were normalized in the puerperal period.