bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consideration of Quality of Life in Cancer Survivorship Research
Authors: Jacobsen Paul B. , Jim Heather S.L. 
Published: October 2011

Abstract
Quality of life assessment has a number of important applications in research on cancer survivors. These applications include use in observational studies to characterize the nature and extent of problems patients experience as well as use in randomized controlled trials to evaluate the relative impact of different cancer treatments or to evaluate the efficacy of interventions designed to improve patient well-being. The aims of this article are to provide an overview of the construct of quality of life and describe strategies commonly used to measure quality of life in adult cancer survivors. In addition, several priorities for future research are identified that involve how quality of life is measured, in whom it is measured, and what uses are made of quality of life data in the clinical care of cancer survivors. Cancer Epidemiol Biomarkers Prev; 20(10); 2035–41. ©2011 AACR.
Intra-articular injections of sodium hyaluronate (Hyalgan®) in osteoarthritis of the knee. a randomized, controlled, double-blind, multicenter trial in the asian population
Authors: Huang Teng-Le , Chang Chi-Ching , Lee Chian-Her , Chen Shih-Ching , Lai Chien-Hung , Tsai Ching-Lin 
Published: October 2011

Abstract

Background
The efficacy and tolerability of 500-730 kDa sodium hyaluronate (Hyalgan®) for treatment of osteoarthritis (OA) pain has been established in clinical trials, but few data are available in the Asian population. We conducted a randomized, double-blind, multicenter, placebo-controlled study to evaluate the efficacy and tolerability of this preparation in a Taiwanese population.

Methods
Two hundred patients with mild to moderate OA of the knee were randomized to receive five weekly intra-articular injections of sodium hyaluronate or placebo. The primary efficacy outcome was the change from baseline to Week 25 in patients' evaluation of pain using a 100-mm visual analog scale (VAS) during the 50-foot walking test. Additional outcomes included Western Ontario and McMaster Universities (WOMAC) scores, time on the 50-foot walking test, patient's and investigator's subjective assessment of effectiveness, acetaminophen consumption, and the amounts of synovial fluid.

Results
The Hyalgan® treatment group showed a significantly greater improvement from baseline to Week 25 in VAS pain on the 50-foot walking test than the placebo group (p = 0.0020). The Hyalgan® group revealed significant improvements from baseline to week 25 in WOMAC pain and function score than the placebo group (p = 0.005 and 0.0038, respectively) Other outcomes, such as time on the 50-foot walking test and subjective assessment of effectiveness, did not show any significant difference between groups. Both groups were safe and well tolerated.

Conclusions
The present study suggests that five weekly intra-articular injections of sodium hyaluronate are well tolerated, can provide sustained relief of pain, and can improve function in Asian patients with osteoarthritis of the knee.

Level of Evidence
Therapeutic study, Level I-1a (randomized controlled trial with a significant difference).

Trial registration
ClinicalTrials.gov Identifier: NCT01319461
Nano-structure fabrication of GaAs using AFM tip-induced local oxidation method: different doping types and plane orientations
Authors: Ahn Jung-Joon , Moon Kyoung-Sook , Koo Sang-Mo 
Published: October 2011

AbstractIn this study, we have fabricated nano-scaled oxide structures on GaAs substrates that are doped in different conductivity types of p- and n-types and plane orientations of GaAs(100) and GaAs(711), respectively, using an atomic force microscopy (AFM) tip-induced local oxidation method. The AFM-induced GaAs oxide patterns were obtained by varying applied bias from approximately 5 V to approximately 15 V and the tip loading forces from 60 to 180 nN. During the local oxidation, the humidity and the tip scan speed are fixed to approximately 45% and approximately 6.3 μm/s, respectively. The local oxidation rate is further improved in p-type GaAs compared to n-type GaAs substrates whereas the rate is enhanced in GaAs(100) compared to and GaAs(711), respectively, under the identical conditions. In addition, the oxide formation mechanisms in different doping types and plane orientations were investigated and compared with two-dimensional simulation results.
Approach to the Diagnosis and Treatment of Neonatal Hypothyroidism
Authors: LaFranchi Stephen H. 
Published: October 2011

AbstractCongenital hypothyroidism, occurring in 1:3000 newborns, is one of the most common preventable causes of mental retardation. Neurodevelopmental outcome is inversely related to the age of diagnosis and treatment. Infants detected through newborn screening programs and started on l-T4 in the first few weeks of life have a normal or near-normal neurodevelopmental outcome. The recommended starting dose of l-T4 (10–15 μg/kg · d) is higher on a weight basis than the dose for children and adults. Tailoring the starting l-T4 dose to the severity of the hypothyroidism will normalize serum T4 and TSH as rapidly as possible. It is important to obtain confirmatory serum thyroid function tests before treatment is started. Further diagnostic studies, such as radionuclide uptake and scan and ultrasonography, may be performed to determine the underlying cause of hypothyroidism. Because results from these tests generally do not alter the initial treatment decision, however, these diagnostic studies are rarely indicated. The developing brain has a critical dependence on thyroid hormone for the first 2–3 yr of life; thus, monitoring occurs at more frequent intervals than in older children and adults. Serum free T4 and TSH should be checked at intervals frequent enough to ensure timely adjustment of l-T4 dosing and to keep serum free T4 and TSH levels in target ranges. Given the success of early detection and treatment of neonates with congenital hypothyroidism, a public health mandate should be to develop similar programs for the 75% of babies worldwide who are born in areas without newborn screening programs.
The Effects of Kisspeptin-10 on Reproductive Hormone Release Show Sexual Dimorphism in Humans
Authors: Jayasena Channa N. , Nijher Gurjinder M. K. , Comninos Alexander N. , Abbara Ali , Januszewki Adam , Vaal Meriel L. , Sriskandarajah Labosshy , Murphy Kevin G. , Farzad Zohreh , Ghatei Mohammad A. , Bloom Stephen R. , Dhillo Waljit S. 
Published: October 2011

Abstract

Background:
Kisspeptin peptides are critical in human reproductive physiology and are potential therapies for infertility. Kisspeptin-10 stimulates gonadotropin release in both male and female rodents. However, few studies have investigated the effects of kisspeptin-10 on gonadotropin release in humans, and none have investigated the effect in women. If kisspeptin is to be useful for treating reproductive disease, its effects in both men and women must be established.

Aim:
To compare the effects of kisspeptin-10 administration on reproductive hormone release in healthy men and women.

Methods:
Intravenous bolus kisspeptin-10 was administered to men and women (n = 4–5 per group). Subcutaneous bolus and iv infusion of kisspeptin-10 was also administered to female women (n = 4–5 per group). Circulating reproductive hormones were measured.

Results:
In healthy men, serum LH and FSH were elevated after iv bolus kisspeptin-10, at doses as low as 0.3 and 1.0 nmol/kg, respectively. In healthy women during the follicular phase of the menstrual cycle, no alterations in serum gonadotropins were observed after iv bolus, sc bolus, or iv infusion of kisspeptin-10 at maximal doses of 10 nmol/kg, 32 nmol/kg, and 720pmol/kg/min, respectively. In women during the preovulatory phase, serum LH and FSH were elevated after iv bolus kisspeptin-10 (10 nmol/kg).

Conclusion:
Kisspeptin-10 stimulates gonadotropin release in men as well as women during the preovulatory phase of menstrual cycle but fails to stimulate gonadotropin release in women during the follicular phase. The sexual dimorphism of the responsiveness of healthy men and women to kisspeptin-10 administration has important clinical implications for the potential of kisspeptin-10 to treat disorders of reproduction.
Identifying Soybean Traits of Interest for Weed Competition
Authors: Place George T. , Reberg‐Horton S. Chris , Dickey David A. , Carter Thomas E. 
Published: October 2011

ABSTRACTOrganic soybean [Glycine Max (L.) Merr.] producers rely on a variety of tactics for weed management. The use of soybean cultivars with enhanced ability to compete with weeds may increase weed control. Our objective was to identify genetic traits that may enhance soybean's competitive ability to suppress weeds. Experimental design was a split‐split plot with sets of contrasting soybean genotypes assigned to the main plots, individual genotypes assigned to subplots, and weedy and weed‐free sub‐subplots stripped across blocks for side by side comparison of treatments in weedy and weed‐free conditions. Differences in weed biomass were detected among genotypes in both years at 7 wk after emergence. Narrow‐leaflet small‐seeded natto types were generally poor competitors with weeds. Cultivars released as forage types did not have a consistent advantage over the control. Larger‐seeded tofu genotypes were also variable in weed suppressive ability. However, N04‐8906, the genotype with the greatest 100‐seed weight in this study (24 g), stood out as being among the best for weed suppression, soybean biomass accumulation, ground cover at 3 wk, and early season plant height. Optimum models from multiple regression showed seed size to be the most significant trait measured in overall genotype competitive ability in both years. However, seed size effects on ground cover largely dissipated by 5 wk after emergence.
Short‐Season Soybean Genetic Improvement Evaluated in Weed‐Free and Weedy Conditions
Authors: Cober Elroy R. , Morrison Malcolm J. 
Published: October 2011

ABSTRACTPreviously we found that the genetic improvement rate of soybean [Glycine max (L.) Merr.] increased as plant population increased, indicating that new cultivars were more tolerant to higher population stress. The objectives of the current work were to determine genetic improvement rates under weed interference and to examine agronomic and seed composition responses to weed interference. Twenty maturity group 0 to 00 cultivars released from 1934 to 2007 were grown at Ottawa, ON, from 2006 to 2008 under weed‐free and naturally weedy conditions in a split strip trial. Over all cultivars, yield loss due to weeds ranged from 11 to 80% over years. Genetic improvement under weed‐free conditions ranged from 12.1 to 16.6 kg ha−1 yr−1, similar to previous estimates. Under weedy conditions, estimates of genetic improvement decreased as weed pressure increased, ranging from 14.2 kg ha−1 yr−1 with 11% yield loss to 1.2 kg ha−1 yr−1 with 80% yield loss. Weed interference resulted in inconsistent changes in maturity, plant height, lodging, seed size, and seed protein and oil concentration across the 3 yr of this study. Canopy development was estimated using a measurement of green area from digital images. In weed‐free soybean canopies, newer soybean cultivars had a slower rate of development compared to older cultivars. New cultivars were not more tolerant to weed interference but also were not inferior to old cultivars under weedy conditions.
Proposal for Shift to Reciprocal Recurrent Selections in “Clone and Strain Synthesis” Timothy Breeding using Molecular Marker Diversity
Authors: Tanaka Tsuneki , Tamaki Hiroyuki , Ashikaga Kazunori , Fujii Hiroki , Yamada Toshihiko 
Published: October 2011

ABSTRACTIntegration of reciprocal recurrent selection (RRS) with the formation and use of heterotic groups is a key strategy for yield improvement in timothy (Phleum pratense L.) breeding. This study aims at utilizing putative heterotic groups based on molecular marker diversity in “clone and strain synthesis” (CSS) development. Strains are synthesized by combining two top‐cross progenies, that is, comprising two seed parental clones (SPs) and a pollen parental strain (PP). A significant positive correlation (r = 0.64, p < 0.05) was found between forage yields of 15 (= 6C2) CSS strains and genetic distance estimates among all possible pairs of their six SPs using 28 simple sequence repeat markers. This result suggests that the adoption of elite clones as SPs of CSS strains, selected from putative heterotic groups formed on the basis of molecular markers, results in the efficient development of high‐yielding strains with exploiting specific combining ability (SCA) effects among SPs. The use of CSS has some advantages compared with conventional cultivar synthesis. One is that RRS with two or three heterotic groups can be established in CSS. Another is that current leading cultivars can be utilized as the PP. These advantages and the results presented in this study has led us to a procedure that consists of (i) a division of germplasm pools based on molecular marker diversity and (ii) a confirmation of the separated groups based on test cross progeny tests. The procedure provides an effective introduction of RSS into CSS development.
Responses of Seashore Paspalum Cultivars to Sting and Spiral Nematodes
Authors: Pang Wening , Luc John E. , Crow William T. , Kenworthy Kevin E. , McSorley Robert , Kruse Jason K. , Giblin‐Davis Robin M. 
Published: October 2011

ABSTRACTSting (Belonolaimus longicaudatus Rau) and spiral (Helicotylenchus spp.) nematodes are among the most common and damaging nematode species found on seashore paspalum (Paspalum vaginatum Swartz) in Florida. Restriction and cancellation of nematicides on turfgrass have accelerated the development of more environmentally friendly nematode management strategies. Use of nematode‐tolerant or ‐resistant cultivars is the practice with the least ecological impact on nontargeted species. The objective of this study was to identify the nematode tolerance or resistance of commercial seashore paspalum cultivars. Seven cultivars were tested under greenhouse conditions in two sequential trials. The cultivars were grown in sand‐filled plastic conetainers and inoculated with 50 sting nematodes or 500 spiral nematodes conetainer−1. Nematode and root samples were collected 90 d after nematode inoculation. All seashore paspalum cultivars supported the reproduction of sting nematode, with a reproduction rate of 2.7‐ to 9.5‐fold in the two trials. Population densities of the spiral nematode H. pseudorobustus (Steiner, 1914) Golden, 1956 declined on all cultivars. Seashore paspalum cultivars showed differences in root length reductions caused by nematodes. ‘Salam’, ‘SeaDwarf’, and ‘SeaIsle Supreme’ were most tolerant to sting nematode, and ‘SeaSpray’ and ‘SeaIsle 2000’ were most tolerant to spiral nematode. No cultivar was tolerant to both nematode species.
Stripe Rust Resistance in the Wheat Cultivar Jagger is Due to Yr17 and a Novel Resistance Gene
Authors: Fang Tilin , Campbell Kimberly G. , Liu Zhiyong , Chen Xianming , Wan Anmin , Li Shan , Liu Ziji , Cao Shuanghe , Chen Yihua , Bowden Robert L. , Carver Brett F. , Yan Liuling 
Published: October 2011

ABSTRACTYellow rust, also known as stripe rust, is caused by Puccinia striiformis Westend. f. sp. tritici Eriks (PST) and is one of the most common and persistent wheat (Triticum aestivum L.) diseases worldwide. A mapping population of recombinant inbred lines from the cross of ‘Jagger’ (moderately resistant) × ‘2174’ (moderately susceptible) was tested at three sites in Washington where predominant races PST‐114 and PST‐116 naturally occurred, at Rossville, KS, where PST‐100 was inoculated, and in Beijing, China, where a predominant Chinese stripe rust race CYR32 was inoculated on adult plants. A major quantitative trait locus for adult‐plant stripe rust resistance was located on the short arm of chromosome 2A (QYr.osu‐2A), where Jagger was found to carry markers for resistance gene Yr17 from Aegilops ventricosa Tausch (syn. Triticum ventricosum). Therefore, Yr17 is likely the resistance gene on chromosome 2A in Jagger. Markers for Yr17 were found to occur frequently in cultivars from the southern Great Plains but only occasionally in cultivars from other U.S. wheat regions. A novel resistance gene was mapped on the long arm of chromosome 5A (QYr.osu‐5A), for which the Jagger allele showed consistent resistance to multiple races of the stripe rust pathogen. A significant genetic effect of the resistance gene Lr34/Yr18 from 2174 was detected only when the population was tested with CYR32 in China.
Genetic Effects of Background‐Independent Loci for Grain Weight and Shape Identified using Advanced Reciprocal Introgression Lines from Lemont × Teqing in Rice
Authors: Zheng T. Q. , Wang Y. , Ali A. J. , Zhu L. H. , Sun Y. , Zhai H. Q. , Mei H. W. , Xu Z. J. , Xu J. L. , Li Z. K. 
Published: October 2011

ABSTRACTGenetic background effect and environmental sensitivity are two major obstacles for marker‐assisted breeding (MAB) of complex traits. Background‐independent (BI) loci for 1000‐grain weight (TGW) and grain shape (GS) were detected over three seasons using a set of reciprocal introgression lines (ILs) from Lemont × Teqing cross with parents having distinctive GS but equal TGW. Reciprocal ILs in advanced (F11–13) generations were genotyped using 142 polymorphic simple sequence repeat (SSR) markers on 64 chromosome bins. Nineteen bins of BI loci significantly associated with TGW and/or GS that were identified consistently over multiple seasons and additive effects were in the opposite directions at the same loci between two backgrounds. These 19 bins could be classified into three types: Type I includes four genetic overlapping bins affecting both TGW and GS, Type II includes nine genetic overlapping bins controlling GS component traits, and Type III includes six bins for single GS component. Among them, five stably expressed BI loci (bins 2.2, 2.5, and 3.7 for grain length [GL] and bins 5.2 and 7.4 for grain width [GW]) found consistently over three seasons would be the first choice for MAB. Secondary choice would be the loci that expressed over at least over two seasons and include bins 1.2, 3.3, 4.3 for GL and bins 7.1 and 11.5 for GW. Two related key traits, one for yield (TGW) and the other for grain quality (GS), can now be fully utilized through marker‐aided transfer or pyramiding of the identified BI loci in rice (Oryza sativa L.) improvement programs.
Single-walled carbon nanotubes fractionation via electrophoresis
Authors: Scheibe Blazej , Lukaszczuk Pawel , Rümmeli Mark , Kalenczuk Ryszard , Borowiak-Palen Ewa 
Published: October 2011

Single-walled carbon nanotubes fractionation via electrophoresis
This work presents the influence of the sonication time on the efficiency of the metallic/semiconducting (M/S) fractionation of diazonium salt functionalized single-walled carbon nanotubes (SWCNTs) via free solution electrophoresis (FSE) method. The SWCNTs synthesized via laser ablation were purified from amorphous carbon and catalyst particles through high vacuum annealing and subsequent refluxing processes in aqua regia solutions, respectively. The purified material was divided into two batches. The SWCNTs samples were dispersed in 1% SDS solution in ultrasound bath for 2 and 12 hours. Both dispersed SWCNTs samples were functionalized with p-aminobenzoic acid diazonium salt and fractionated via free solution electrophoresis method. Afterwards, the fractionated samples were recovered, purified from surfactant/functionalities by annealing and investigated via UV-Vis-NIR optical absorption spectroscopy (OAS). The efficiency of the fractionation process was estimated through the comparison of the van Hove singularities (vHS) presented in the obtained fractions to the starting SWCNTs.
Analysis of Czech organizations participation in the Competitiveness and Innovation Framework Programme
Authors: Procházka Lukáš 
Published: October 2011

Analýza účasti českých organizací v Rámcovém programu pro konkurenceschopnost a inovace
Příspěvek se zabývá českou účastí v Rámcovém programu pro konkurenceschopnost a inovace (CIP), který je jedním z nástrojů, s jejichž pomocí se EU snaží podporovat rozvoj konkurenceschopnosti členských států. Příspěvek analyzuje jednotlivé podprogramy, z nichž je program CIP složen, zabývá se charakterem projektů s českou účastí a strukturou účastníků v těchto projektech. Pro porovnání s okolními státy obsahuje příspěvek také analýzu účasti polských a slovenských subjektů.
Du côté d'Ammaedara (Haïdra): Musulamii et Musunii Regiani
Authors: Benzina Ben Abdallah Zeïneb 
Published: October 2011

II s'agit d'un nouveau témoignage épigraphique sur la présence des deux tribus des Musulamii et Musunii Regiani dans le centre-ouest de l'Afrique proconsulaire, au IIe siècle après J.-C. Ce texte qui provient d'Ammaedara confirme, par ailleurs, que la charge de praefectus gentis (délégué sur place par le pouvoir central pour diriger les tribus) était, à partir du règne de Trajan, confiée, de plus en plus, à des civils plutôt qu'à des militaires. En outre, il mentionne explicitement que ces deux gentes étaient soumises à l'autorité d'un seul praefectus.
Il est donc permis de conclure que le titre de praefectus gentium, quand il apparaît sans autre précision, n'englobait pas nécessairement l'ensemble des tribus de l'Afrique proconsulaire.
Isolation and characterization of microsatellite markers for Dipteronia dyerana (Sapindaceae), an endangered endemic species in China
Authors: Chen Chen , Ren Bing‐Bing , Xu Xi‐Hui , Fu Cheng‐Xin , Qiu Ying‐Xiong 
Published: October 2011

• Premise of the study: Microsatellite markers were developed for Dipteronia dyerana, an endangered endemic species in China, to study the population genetics of this species.• Methods and Results: Using the Fast Isolation by AFLP of Sequences Containing repeats (FIASCO) protocol, 12 microsatellite markers that were successfully amplified showed polymorphism when tested on 31 individuals from two populations in the counties of Wenshan and Mengzi. Overall, the number of alleles per locus ranged between seven and 25, with an average of 12.3. Nine of these markers were able to be amplified in D. sinensis.• Conclusions: These microsatellite markers should facilitate further studies on the population genetics and the reproductive ecology of Dipteronia.
L'infertilité comme analyseur de la parentalité
Authors: Bourdet-Loubère Sylvie , Mazoyer Anne-Valérie 
Published: October 2011

Résumé La souffrance des couples « en mal d’enfant », les difficultés du parcours thérapeutique et la construction de la parentalité dans ces situations inédites sont éclairées par une présentation de situations cliniques rencontrées dans un service d’Aide Médicale à la Procréation (AMP). Les auteurs évoquent par exemple la demande d’un enfant « coûte que coûte », l’idéalisation de l’enfant issu de l’AMP ou encore le choix de l’adoption.
L'insoutenable de l'enfant réel
Authors: Juliot Lucie 
Published: October 2011

Résumé Mme K. vient nous enseigner quelque chose de ce hiatus qui demeure entre la mère et la femme. Elle ne parvient pas à élaborer cette question de « l’être mère », l’enfant est en place d’objet réel, insoutenable, qu’elle évacue ou qui peut disparaître. Chaque maternité se déroule sous le sceau de l’angoisse, angoisse qui la mène vers le passage à l’acte. Mme K est happée par cet illimité, par cette toute puissance que peut avoir une mère sur son enfant.