bluuebunny/crossref_metadata_2025_split huggingface dataset:
A genomics-informed, SNP association study reveals FBLN1 and FABP4 as contributing to resistance to fleece rot in Australian Merino sheep
Authors: Smith Wendy JM , Li Yutao , Ingham Aaron , Collis Eliza , McWilliam Sean M , Dixon Tom J , Norris Belinda J , Mortimer Suzanne I , Moore Robert J , Reverter Antonio 
Published: May 2010

Abstract

Background
Fleece rot (FR) and body-strike of Merino sheep by the sheep blowfly Lucilia cuprina are major problems for the Australian wool industry, causing significant losses as a result of increased management costs coupled with reduced wool productivity and quality. In addition to direct effects on fleece quality, fleece rot is a major predisposing factor to blowfly strike on the body of sheep. In order to investigate the genetic drivers of resistance to fleece rot, we constructed a combined ovine-bovine cDNA microarray of almost 12,000 probes including 6,125 skin expressed sequence tags and 5,760 anonymous clones obtained from skin subtracted libraries derived from fleece rot resistant and susceptible animals. This microarray platform was used to profile the gene expression changes between skin samples of six resistant and six susceptible animals taken immediately before, during and after FR induction. Mixed-model equations were employed to normalize the data and 155 genes were found to be differentially expressed (DE). Ten DE genes were selected for validation using real-time PCR on independent skin samples. The genomic regions of a further 5 DE genes were surveyed to identify single nucleotide polymorphisms (SNP) that were genotyped across three populations for their associations with fleece rot resistance.

Results
The majority of the DE genes originated from the fleece rot subtracted libraries and over-representing gene ontology terms included defense response to bacterium and epidermis development, indicating a role of these processes in modulating the sheep's response to fleece rot. We focused on genes that contribute to the physical barrier function of skin, including keratins, collagens, fibulin and lipid proteins, to identify SNPs that were associated to fleece rot scores.

Conclusions
We identified FBLN1 (fibulin) and FABP4 (fatty acid binding protein 4) as key factors in sheep's resistance to fleece rot. Validation of these markers in other populations could lead to vital tests for marker assisted selection that will ultimately increase the natural fleece rot resistance of Merino sheep.
The multiple faces of CXCL12 (SDF-1α) in the regulation of immunity during health and disease
Authors: Karin Nathan 
Published: May 2010

Abstract
Review discusses the role of CXCL12 (SDF1α) as a regulatory chemokine that drives Foxp3- regulatory T cells (Tr1), and its therapeutic implications.
Chemokines are a group of small, structurally related molecules that regulate the trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane G-protein-coupled receptors. As key chemoattractants of inflammatory leukocytes, chemokines have been marked as potential targets for neutralization in autoimmune diseases. Cancer cells also express chemokines, where they function as survival/growth factors and/or angiogenic factors that promote tumor development and angiogenesis. Accordingly, these functions make them attractive targets for therapy of these diseases. Recently, we reported that one of these chemokines CXCL12 (SDF-1α) functions as an anti-inflammatory chemokine during autoimmune inflammatory responses and explored the mechanistic basis of this function. As a pleiotropic chemokine, CXCL12 participates in the regulation of tissue homeostasis, immune surveillance, autoimmunity, and cancer. This chemokine is constitutively expressed in the BM and various tissues, which enables it to regulate the trafficking and localization of immature and maturing leukocytes, including BM stem cells, neutrophils, T cells, and monocytic cells. We have shown recently that CXCL12 increases immunological tolerance in autoimmune diseases by polarizing Tregs and by doing so, restrains the progression of these diseases. This finding suggests a possible use of stabilized rCXCL12 as a potential drug for therapy of these diseases and targeted neutralization of CXCL12 for therapy of cancer diseases. The current review explores the different biological properties of CXCL12 and discusses the implications of CXCL12-based therapies for autoimmunity and cancer diseases.
Multifunctional Spin-carrying Anthraquinone Derivatives
Authors: Shibata Yuuki , Akutsu Hiroki , Yamada Jun-ichi , Satoh Masaharu , Hiremath Uma S , Yelamaggad Channabasaveshwar V , Nakatsuji Shin’ichi 
Published: May 2010

Abstract
Several nitroxide radicals derived from 2,3,6,7-tetraalkoxy-9,10-anthraquinone core have been prepared and their magnetic, redox as well as battery properties are studied. Notably, one of the derivatives with a mono-PROXYL-radical substituent exhibits a fairly stable multistep charge–discharge process and a heat-responsive magnetic behavior.
Cation-specific Transition from Vesicle to Lamella for an Aromatic Diamine Lipid in Aqueous Solutions
Authors: Nishimura Tomoki , Masunaga Hiroyasu , Ogawa Hiroki , Akiba Isamu , Sakurai Kazuo 
Published: May 2010

Abstract
Addition of Cu2+ or Pd2+ into a novel aromatic diamine lipid in water induced vesicle–lamella transition. Combining scattering and calorimetry revealed that the metals first coordinated on the vesicle surface and then induced flattening and stacking of the bilayer to form highly ordered lamellae. This is the first report of the Pd2+-induced structural transition of micelles.
External ophthalmomyiasis caused by Oestrus ovis in Istanbul
Authors: Arslan Ferhat , Mete Birgül , Öztürk Recep , Samasti Mustafa 
Published: May 2010

Summary Ophthalmomyiasis externa is mainly caused by the sheep botfly Oestrus ovis; therefore, it is usually seen in rural areas. We report here a case of ophthalmomyiasis externa in a young man from Istanbul. The patient had no known history of exposure to farm animals or rural areas.
Estimating Nonparametric Random Utility Models with an Application to the Value of Time in Heterogeneous Populations
Authors: Bastin Fabian , Cirillo Cinzia , Toint Philippe L. 
Published: May 2010

The estimation of random parameters by means of mixed logit models is now current practice for the analysis of transportation behaviour. One of the most straightforward applications is the derivation of willingness-to-pay distribution over a heterogeneous population, an important element for dynamic tolling strategies on congested networks. In numerous practical cases, the underlying discrete choice models involve parametric distributions that are a priori specified and whose parameters are estimated. This approach can however lead to many problems for realistic interpretation, such as negative value of time, etc. In this paper, we propose to capture the randomness present in the model by using a new nonparametric estimation method, based on the approximation of inverse cumulative distribution functions. This technique is applied to simulated data, and the ability to recover both parametric and nonparametric random vectors is tested. The nonparametric mixed logit model is also used on real data derived from a stated preference survey conducted in the region of Brussels (Belgium). The model presents multiple choices and is estimated on repeated observations. The obtained results provide a more realistic interpretation of the observed behaviours.
The Prophylactic Role for the Human Papillomavirus Quadrivalent Vaccine in Males
Authors: Yancey Abigail M , Pitlick Jamie M , Forinash Alicia B 
Published: May 2010

Objective: To determine the role of human papillomavirus (HPV) quadrivalent vaccine in males. Data Source: PubMed (1966–March 2010) was searched using the terms human papillomavirus, human papillomavirus vaccine, quadrivalent, males, cancer, and genital warts. Reference citations were reviewed for relevant information. Study Selection and Data Extraction: All studies including humans and published in English with data describing HPV quadrivalent vaccine administration in males were evaluated. Data Synthesis: The HPV quadrivalent vaccine is currently recommended in females, but its role in males is still being defined. Three clinical trials evaluated the immunogenicity and tolerability of the vaccine in more than 1100 males 9–26 years of age. Greater than 99.5% of males seroconverted for HPV 6, 11, 16, and 18 at 1 month post-completion and titers were found to be numerically higher than those in females 16–26 years old. One study found that immune response persisted in >92.5% of males at 1 year. The results show high efficacy against detection of new anogenital lesions in males 29 months after receiving the quadrivalent HPV vaccine. In addition, the quadrivalent HPV vaccine appears to be well tolerated, with the most common adverse effects being syncope, fever, local site reactions, dizziness, nausea, and headache. Conclusions: The HPV quadrivalent vaccine appears to be safe and induces an effective immune response in males. It may also decrease the incidence of anogenital and penile cancer, although current data are limited in number and duration of follow-up. Further analysis of the long-term immunogenicity and effects on HPV-associated complications is needed.
Maintenance of Risk Factor Control in Diabetic Patients with and Without Mental Health Conditions After Discharge from a Cardiovascular Risk Reduction Clinic
Authors: Cohen Lisa B , Taveira Tracey H , Wu Wen-Chih , Pirraglia Paul A 
Published: May 2010

Background: Diabetes and hypertension can be challenging to manage in patients with mental health conditions. While the effectiveness of a cardiovascular risk reduction clinic (CRRC) has been shown not to differ between those with and without mental health conditions, it is unknown whether patients with mental health conditions would differ in durability of success following discharge from the CRRC. Objective: To determine the effect of mental health conditions on the maintenance of glycemic control and blood pressure control in patients with diabetes following successful completion of a CRRC program. Methods: Patients were discharged from the CRRC when therapeutic goals of hemoglobin A1c (A1C) <7% and blood pressure <130/80 mm Hg were achieved. We performed a retrospective chart review of a cohort of 231 patients by quarterly intervals for A1C and systolic blood pressure (SBP), providing up to 3 years of data following discharge from the CRRC. We assessed the time to failure to maintain goal A1C and SBP following CRRC discharge for patients with diagnosed mental health conditions versus patients without mental health conditions. Results: For patients with and without mental health conditions, 50% of those who had been discharged from the CRRC with an SBP goal of <130 mm Hg failed to maintain SBP by 1 quarter. The hazard ratio for failure to maintain SBP, with those without mental health conditions as the reference group, was 0.96 (95% CI 0.68 to 1.35). Overall, for patients with an A1C goal of <7%, the combined median time to failure was 3 quarters. Among patients without mental health conditions, 25% failed in 3 quarters, and of those with mental health conditions, 25% failed in 4 quarters (HR 0.91; 95% CI 0.50 to 1.66). Conclusions: There was no significant difference between diabetic patients with and without mental health conditions in maintenance of A1C and SBP after discharge from a CRRC. This provides further evidence that a CRRC is a viable approach to cardiovascular risk reduction in individuals with mental health conditions.
Correction for the 17O interference in δ(13C) measurements when analyzing CO2 with stable isotope mass spectrometry (IUPAC Technical Report)
Authors: Brand Willi A. , Assonov Sergey S. , Coplen Tyler B. 
Published: May 2010

Measurements of δ(13C) determined on CO2 with an isotope-ratio mass spectrometer (IRMS) must be corrected for the amount of 17O in the CO2. For data consistency, this must be done using identical methods by different laboratories. This report aims at unifying data treatment for CO2 IRMS by proposing (i) a unified set of numerical values, and (ii) a unified correction algorithm, based on a simple, linear approximation formula. Because the oxygen of natural CO2 is derived mostly from the global water pool, it is recommended that a value of 0.528 be employed for the factor λ, which relates differences in 17O and 18O abundances. With the currently accepted N(13C)/N(12C) of 0.011 180(28) in VPDB (Vienna Peedee belemnite) reevaluation of data yields a value of 0.000 393(1) for the oxygen isotope ratio N(17O)/N(16O) of the evolved CO2. The ratio of these quantities, a ratio of isotope ratios, is essential for the 17O abundance correction: [N(17O)/N(16O)]/[N(13C)/N(12C)] = 0.035 16(8). The equation [δ(13C) ≍ 45
δ
VPDB-CO2 + 2 17
R/13
R (45
δ
VPDB-CO2 – λ46
δ
VPDB-CO2)] closely approximates δ(13C) values with less than 0.010 ‰ deviation for normal oxygen-bearing materials and no more than 0.026 ‰ in extreme cases. Other materials containing oxygen of non-mass-dependent isotope composition require a more specific data treatment. A similar linear approximation is also suggested for δ(18O). The linear approximations are easy to implement in a data spreadsheet, and also help in generating a simplified uncertainty budget.
Indicators and quality specifications for strategic and support processes related to the clinical laboratory: four years' experience
Authors: Ruiz Rosa , Llopis Ma Antònia , Biosca Carme , Trujillo Gloria , Llovet Ma Isabel , Tarrés Ester , Ibarz Mercè , Alsina Ma Jesus , Alvarez Virtudes , Busquets Glòria , Doménech Ma Vicenta , Figueres Carme , Minchinela Joana , Pastor Rosa Ma , Perich Carmen , Ricós Carmen , Sansalvador Mireia , Simón Margarita 
Published: May 2010

Abstract

Background: Quality specifications for indicators of the key analytic processes have been defined by international consensus. However, only preliminary specifications for laboratory-related strategic and support processes have been developed. The present study attempts to increase the robustness of the preliminary proposed specifications.

Methods: Recovering records and incidences occurred over a 4-year follow-up period, for 12 indicators, used in all laboratories from this group regarding strategic and support processes.

Results and conclusions: The results obtained indicate that it is better to establish an interval rather than a fixed value for the majority of indicators. Longer studies are needed to properly assess some quality specifications, and data recording system must be standardized in others. Additional, multicenter studies are needed to establish more robust specifications and determine the state of the art of laboratories in other settings.
Clin Chem Lab Med 2010;48:1015–9.
On the genesis of personal pronouns: Some conceptual sources
Authors: Heine Bernd , Song Kyung-An 
Published: May 2010

AbstractPersonal pronouns belong to the most conservative parts of grammar; that is, they are diachronically fairly stable, as suggested by the fact that in many cases they can be traced back etymologically to or even beyond the earliest stages of reconstructible language history. This is why so far not much progress has been made in unraveling the genesis of personal pronouns: the number of cases where it has been possible to determine their origin is severely limited. Still, some data do exist and allow for the reconstruction of some major lines of grammatical evolution. As we hope to show in this paper, this evolution is the product of a handful of crosslinguistically fairly uniform cognitive and communicative strategies.
The heterogeneity of cell subtypes from a primary culture of human amniotic fluid
Authors: Zhang Shengli , Geng Hongquan , Xie Hua , Wu Qiquan , Ma Xiaorong , Zhou Junmei , Chen Fang 
Published: May 2010

AbstractHeterogeneous human amniotic fluid contains various cell types. Herein, we report on the possibility of simultaneously isolating three subtypes of cells from one primary culture. Using a stainless steel instrument named a colony poculum, two of the three cell subtypes could be efficiently cultured, and these were further characterized. The results indicated that these two cell subtypes had different morphologies and were characterized by different cell marker expression profiles, including the differential expression of CD105, CD117 and EBAF. Furthermore, their gene expression array data revealed their different gene expression profiles. Although both cell types expressed several embryonic stem cell-specific markers, they were non-tumorigenic in vivo. This paper not only provides new insight into the heterogeneity of human amniotic fluid, it also presents a simple yet efficient cell isolation method. These results will contribute to the thorough investigation of the properties and potential future applications of human amniotic fluid-derived cells.
Morphology, anatomy and ecology of critically endangered endemic <I>Crocus pestalozzae</I> Boiss. (Iridaceae) in North-West Turkey
Authors: Kandemir Nezahat 
Published: May 2010

Morphology, anatomy and ecology of endemic species Crocus pestalozzae Boiss. (Iridaceae), have been investigated during flowering period in early spring. The bulbous plant grows in moist heath, meadowland and rocky areas in the North-West of Turkey. Morphological properties of plant parts have been described in detail. Transverse sections of roots, stems and leaves have been illustrated and the anatomical characters of arms, keel, papillae, mesophyll and vascular bundles of leaf have been described. Population status of the plant has also been determined. Key words: Crocus pestalozzae Boiss.; Endemic; Morphology; Anatomy; Ecology; Turkey DOI: 10.3329/bjb.v38i2.5136 Bangladesh J. Bot. 38(2): 127-132, 2009 (December)
Pratiques culturelles et carrières d'amateurs : le cas des parcours de cavaliers dans les clubs d'équitation
Authors: Chevalier Vérène 
Published: May 2010

Careers in cultural practice: amateur trajectories in horse-riding
This paper focuses on dropping out, both as a phenomenon per se and as a marker for the dynamic dimension of amateur involvement in cultural activities. I examine amateur behavior and the classical understanding of amateur populations. Focusing on the longitudinal characteristics of individual practice shows that these individuals appear to be much more versatile than expected. Far from being stable, individual amateur practices can be seen as steps in the social construction of an amateur iden tity. This construction is the result of two processes: on the one hand, a process of socialization in clubs, with other amateurs at various stages in their career on the other hand, a process of acquisition of a specific institutional culture.
Les entretiens informels
Authors: Bruneteaux Patrick , Lanzarini Corinne 
Published: May 2010

Informal interviews
The formal interview used with people from the underclass often leads to the confrontation of two worlds: the ordinary world embodied by the sociologist, and the world of survival emergency experienced by the person being interviewed. Sometimes this gap between interviewer and respondent can get so large that the interaction produces onirism, stereotyped stories, reactions of violence, and a resistance to being questioned. To overcome these problems with interviewing in these circumstances, we propose an approach inspired by the sociologists of the Chicago School: using informal interviews. Using a method of oriented conversation, the sociologist adjusts the interview topics so the interaction more closely resembles a conversation. This approach has a better chance of establishing a relationship based on common humanity.
Parenté et adoption
Authors: Ouellette Françoise-Romaine 
Published: May 2010

Kinship and Adoption
This article considers the recent changes of legal adoption in Quebec, interpreting this evolution as the result of an increasing dissociation between the juridical, biological and psychological (or emotional) aspects of kinship. It underlines the influence of the social values of equality and affectivity on the main orientations taken in domestic and inter-country adoptions. It also stress the increasing autonomy of the family from the domain of kinship.
Le tronc au pendu, quelques remarques sur le passé de la drogue en Europe de l'Ouest
Authors: Poly Jean-Pierre 
Published: May 2010

Résumé Dans cet article, nous commencerons par retracer le parcours des termes « addiction » et « drogue », avant d’aborder un troisième concept qui va nous emmener très loin en Europe de l’Est : le chamanisme. Nous décrirons deux types de chamanisme : le germanique et le scythique, puis nous concentrerons notre examen sur la possession et le démembrement, avant de proposer quelques hypothèses de réflexion, notamment autour du concept d’addiction en tant que dette de mort et désenchantement du monde.
Caractéristiques familiales associées à l'initiation précoce à la consommation de psychotropes à la préadolescence
Authors: Lussier Karine , Laventure Myriam 
Published: May 2010

Résumé La présente étude a pour objectifs de décrire et comparer les caractéristiques relatives à la structure familiale, aux caractéristiques des parents et aux pratiques éducatives parentales associées à la consommation de psychotropes chez les enfants de moins de 12 ans et de déterminer celles qui y sont les plus fortement associées. Les participants sont 226 enfants (137 filles), âgés en moyenne de 10,98 ans (é.t. 0.64). Les résultats indiquent que c’est sur le plan des pratiques éducatives parentales que se distinguent principalement les enfants initiés à la consommation et ceux ne s’y étant pas initiés. Parmi les caractéristiques de l’étude, ce sont la qualité de l’engagement parental et la présence de constance de la discipline, qui distinguent le plus fortement les enfants de deux groupes, avantageant les enfants non initiés à la consommation de psychotropes. Ces résultats sont discutés en fonction des retombées pour la prévention et l’intervention.
Derrière le masque de la toxicomanie. Une modalité particulière de prise en charge institutionnelle, articulation entre théorie et clinique
Authors: Heinrich-Leget Catherine , Jacob Claude 
Published: May 2010

Résumé La question de la place de l’objet drogue dans l’économie psychique du sujet est une question cruciale en ce qu’elle permet d’aller au-delà du masque de la toxicomanie, de l’image de toxicomane présentée d’emblée par le patient comme une évidence, comme s’il pouvait se résumer à cela : « je suis toxicomane ». Tout l’enjeu consiste alors à l’amener à se différencier, à se définir autrement au travers de la parole, au travers de mots qui vont le représenter. La prise en charge institutionnelle, telle qu’elle est pensée au sein du Pôle d’addictologie, articule accompagnement au dehors – au centre d’accueil Baudelaire – et accompagnement au dedans – au Service de soins pour toxicomanes. Elle tente de prendre en compte chaque patient dans sa dimension de subjectivité unique et d’utiliser au mieux les outils thérapeutiques à disposition, notamment les traitements de substitution, dans un contexte institutionnel basé sur des concepts analytiques. Le cas clinique présenté dans cet article, articulé à des notions théoriques illustre bien les aspects transnosographique et transstructural des addictions, aspects qui impliquent une grande souplesse dans la prise en charge et une adaptation à chaque cas singulier.