bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Efficacy of Lymph Node Reoperation for Persistent Papillary Thyroid Cancer
Authors: Al-Saif Osama , Farrar William B. , Bloomston Mark , Porter Kyle , Ringel Matthew D. , Kloos Richard T. 
Published: March 2010

Abstract
Objective: The objective of the study was to determine the outcome of surgical resection of metastatic papillary thyroid cancer (PTC) in cervical lymph nodes after failure of initial surgery and I131 therapy.
Design: This was a retrospective clinical study.
Setting: The study was conducted at a university-based tertiary cancer hospital.
Patients: A cohort of 95 consecutive patients with recurrent/persistent PTC in the neck underwent initial reoperation during 1999–2005. All had previous thyroidectomy (±nodal dissection) and I131 therapy. Twenty-five patients with antithyroglobulin (Tg) antibodies were subsequently excluded.
Main Outcome Measures: Biochemical complete remission (BCR) was stringently defined as undetectable TSH-stimulated serum Tg.
Results: A total of 107 lymphadenectomies were undertaken in these 70 patients through January 2010. BCR was initially achieved in 12 patients (17%). Of the 58 patients with detectable postoperative Tg, 28 had a second reoperation and BCR was achieved in five (18%), seven had a third reoperation, and none achieved BCR. No patient achieving BCR had a subsequent recurrence after a mean follow-up of 60 months (range 4–116 months). In addition, two more patients achieved BCR during long-term follow-up without further intervention. In total, 19 patients (27%) achieved BCR and 32 patients (46%) achieved a TSH-stimulated Tg less than 2.0 ng/ml. Patients who did not achieve BCR had significant reduction in Tg after the first (P &lt; 0.001) and second (P = 0.008) operations. No patient developed detectable distant metastases or died from PTC.
Conclusions: Surgical resection of persistent PTC in cervical lymph nodes achieves BCR, when most stringently defined, in 27% of patients, sometimes requiring several surgeries. No biochemical or clinical recurrences occurred during follow-up. In patients who do not achieve BCR, Tg levels were significantly reduced. The long-term durability and impact of this intervention will require further investigation.
The Guthrie: An Interview with Alvin Epstein and Michael Feingold
Authors: Bly Mark , Schechter Joel 
Published: March 2010

In 1963, the Tyrone Guthrie Theater was founded in Minneapolis as an alternative to Broadway and its commercialism. Despite occasional financial setbacks, Tyrone Guthrie and his British proteges gradually established it as a major classical repertory theater. Guthrie died in 1971, and the British director Michael Langham succeeded him. Under his artistic direction, the Guthrie Theater stabilized and flourished. When Langham announced he would resign at the end of the 1977 season, an international search for his successor commenced. For the first time during the Guthrie's existence, an American was selected for the post of artistic director. Alvin Epstein, formerly Associate Director of the Yale Repertory Theater, was chosen, beginning a new era in the history of the Guthrie. The repertory for Epstein's first season included such plays as The Pretenders, Hamlet, Tiebele and Her Demon, Bonjour, La, Bonjour, and The Marriage.
The following interview with Alvin Epstein and Literary Manager Michael Feingold was conducted by Joel Schechter and Mark Bly on March 8, 1979 in New York.
Working memory and cognitive styles in adolescents' attainment
Authors: Alloway Tracy Packiam , Banner Gloria E. , Smith Patrick 
Published: March 2010

Background. Working memory, the ability to store and process information, is strongly related to learning outcomes.Aims. The aim of the present study is to extend previous research on early learning and investigate the relationship between working memory, cognitive styles, and attainment in adolescents using both national curriculum tests and teacher‐based assessments.Sample. A group of 164 13‐year‐olds from a school in England were recruited.Methods. They took tests of working memory and cognitive styles. The school provided the attainment scores.Results. Working memory was found to be the predictor of learning outcomes in English, Maths, and Science, as well as all teacher assessments. There was also a significant interplay between working memory, styles, and attainment. For students with high working memory, their style preference does not impact attainment. Students most at risk were analytics with low working memory as they performed worse in the most subjects.Conclusions. The findings suggest that the interplay between working memory and cognitive styles can be useful in developing suitable interventions to support students.
Konstruktionen im Spracherwerb
Authors: Behrens Heike 
Published: March 2010

Abstract
The concept of ‘constructions’ covers the range from fully unanalyzed or “frozen” units to abstract and productive schemas that can be used to form new utterances, even with verbs that usually have a different valency (coercion). The dynamic nature of the construction as well as its functional grounding makes the construction particularly suitable for describing and explaining the course of language acquisition. Distributional analyses of the linguistic structures used across development as well as experimental tests on the productivity of these structures are the methodological means to assess the degree of freedom of constructions used at each point in development. In the earliest stages of development children rely heavily on bottom up processes and generalize only slowly. But with growing productivity they are able to generate new utterances top down.
Noch einmal: Partikelverbkonstruktionen
Authors: Knobloch Clemens 
Published: March 2010

AbstractUsing the much debated German particle verb construction as an example, some basic questions of Construction Grammar are investigated: constructional meanings, compositionality of meaning, the role of lexical verb bases, morphological and/or syntactal analysis. It is argued that the traditional mode of presentation in historical-comparative grammar (as practiced by Neogrammarians like Hermann Paul) is “constructional” in spirit and mirrors empirical concern for constructional change and constructional meaning. Prototypical verb particles are analyzed within a pattern of grammaticalization and lexicalization of adverbial relators stemming from deictic “imperatives” comparable with English elements like Down!, Up!, Away!, Out!. These elements are the sources for the evolution of prepositions and copredicative adverbials used to build patterns of “phrasal verbs” and particle constructions.
Zur lexikografischen Inszenierung von Geschlecht. Ein Streifzug durch die Einträge von Frau und Mann in neueren Wörterbüchern
Authors: Nübling Damaris 
Published: March 2010

Abstract
This article analyzes, for the first time, the lexicographic construction of gender in more recent editions of German dictionaries (from 1980 onwards). The article starts by presenting a survey of studies on this topic in other languages (French, Swedish, English). Then the dictionary entries of Frau ‘woman’ and Mann ‘man’ are scrutinized with respect to their definition(s), their structure, and their use in sentences of exemplification. The study shows that a surprisingly high degree of stereotypes still exists, including grammatical differences such as men occurring more frequently in subject positions and women dominating in object positions. While some dictionaries represent clear progress with respect to the representation of gender over time, others are dominated by androcentric attitudes.
Robust Rendezvous of Heterogeneous Euler-Lagrange Systems on Packet-Switched NetworksRobustes Rendezvous von heterogenen Euler-Lagrange Systemen mithilfe paketvermittelnder Netzwerke
Authors: Münz Ulrich , Papachristodoulou Antonis , Allgöwer Frank 
Published: March 2010

Abstract
A robust rendezvous controller design for multi-agent systems (MAS) is presented. The agents are modeled as Euler-Lagrange systems which exchange their position information on a packet-switched communication network, where the resulting communication delay is modeled in a distributed delay framework. A synthesis method for static position feedback controllers for these agents is proposed. It achieves rendezvous for uncertain communication delays with bounded average delay and for heterogeneous uncertain agent dynamics. The controllers only have to satisfy certain design conditions that relate sector bounds of the agent dynamics, Lipschitz bounds of the controllers, and the average communication delays of the network. A major advantage of the presented design condition is that the controller parameters depend only on the dynamics of the corresponding agent and the average communication delay to its neighbors, but not on the dynamics of the other agents or the delays in other parts of the network. This decentralized feature of the controller design is particularly useful for large and heterogeneous MAS. The performance of the controllers is illustrated by simulation.
Bioequivalence between novel ready-to-use liquid formulations of the recombinant human GH Omnitrope and the original lyophilized formulations for reconstitution of Omnitrope and Genotropin
Authors: Fuhr Uwe , Tuculanu Daniel , Berghout Alexander , Balser Sigrid , Schwebig Arnd , Saenger Paul 
Published: March 2010

ObjectiveTwo strengths of a novel ready-to-use liquid preparation of the recombinant human GH (rhGH) Omnitrope were developed to increase the convenience for the patients.DesignOmnitrope 3.3 mg/ml solution or Omnitrope 6.7 mg/ml solution was compared to Omnitrope 5 mg/ml powder and Genotropin 5 mg/ml powder in terms of pharmacokinetics, pharmacodynamics, safety, and local tolerance after a single s.c. dose of 5 mg.MethodsTwo randomized, double-blind, single-dose, three-way crossover studies were carried out in 36 young healthy volunteers each. Endogenous GH secretion was suppressed with a 25-h continuous i.v. infusion of octreotide (40 μg/h) starting 1 h before rhGH administration.ResultsPharmacokinetic parameters were similar for the three treatments in both studies respectively. Bioequivalence criteria were met for area under the concentration–time curve (AUC) andCmax. Likewise, the pharmacodynamic parameters for IGF1, IGF-binding protein 3, and non-esterified fatty acid were similar for all preparations. No differences in adverse events were observed between groups.ConclusionsOmnitrope 3.3 mg/ml solution, 6.7 mg/ml solution, and 5 mg/ml powder, and Genotropin 5 mg/ml powder are bioequivalent, have similar pharmacokinetic and pharmacodynamic profiles, and are equally safe. Overall, the products can be considered to be therapeutically interchangeable.
Inflammatory and endothelial dysfunction markers and proteinuria in persons with type 1 diabetes mellitus
Authors: Sahakyan Karine , Klein Barbara E K , Lee Kristine E , Tsai Michael Y , Klein Ronald 
Published: March 2010

ObjectiveWe examined the relationship of inflammatory and endothelial dysfunction markers with the prevalence and incidence of gross proteinuria (GP) in persons with type 1 diabetes mellitus.DesignA longitudinal population-based cohort of persons with type 1 diabetes mellitus was followed from 1990–1992 through 2005–2007.MethodsPrevalence and 15-year cumulative incidence of GP were defined as outcome variables. Serum high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), soluble vascular cell adhesion molecule-1 (VCAM-1), soluble intercellular adhesion molecule-1, and serum total homocysteine were measured. Multivariate logistic and discrete linear logistic regression modeling was used for data analysis.ResultsAfter controlling for duration of diabetes and other confounding factors, TNF-α (odds ratio (OR) 3.64; 95% confidence interval (CI) 2.33, 5.70), IL-6 (OR 1.41; 95% CI 1.06, 1.88), VCAM-1 (OR 13.35; 95% CI 5.39, 33.07), and homocysteine (OR 2.98; 95% CI 1.73, 5.16) were associated with prevalent proteinuria. Only hsCRP (OR 1.47; 95% CI 1.02, 2.11) was associated with incident proteinuria.ConclusionsThese findings suggest a role of inflammation and endothelial dysfunction as markers and contributors of the development of diabetic nephropathy in persons with type 1 diabetes mellitus.
Comparison of Two Different Models of Anticoagulation Management Services with Usual Medical Care
Authors: Rudd Kelly M. , Dier John G. 
Published: March 2010

Study Objective. To evaluate the safety and economic impact of three models of anticoagulation management services: usual medical care, a nurse‐managed service, and a pharmacist‐managed service.Design. Retrospective medical record review.Setting. An eight‐county health care system in central New York State.Patients. Nine hundred ninety‐six patients (age range 19–99 yrs) who were receiving warfarin therapy for at least 6 months and who had three or more international normalized ratio (INR) values reported during the 1‐year study period; 489 patients (6243 INR values) were in the pharmacist‐managed group, 307 patients (3618 INR values) were in the nurse‐managed group, and 200 patients (3142 INR values) were in the usual care group.Measurements and Main Results. All INR measurements were performed by the central laboratory or by on‐site point‐of‐care testing. Data were queried from calendar year 2003 for the usual care and nurse‐managed services and calendar year 2006 for the pharmacist‐managed service. Anticoagulation indication, INR goal, baseline characteristics, and rates and costs of hospitalization and emergency department visits directly related to anticoagulation therapy were extracted from the medical record. If the INR goal was not documented, a range was assigned as appropriate from the American College of Chest Physicians anticoagulation guidelines. Markers of anticoagulation control—time in range (percentage of time a patient is maintained within their therapeutic range) and percentage of INR values in range—were calculated for each study group. Baseline characteristics were similar among all study groups. The pharmacist‐managed service yielded the lowest rates of hospitalization and emergency department visits, with hospitalizations reduced by 56% versus nurse‐managed service and 61% versus usual care (p<0.01). Emergency department visits were reduced by 78% in both the nurse‐managed and usual care models (p<0.002). Based on visit rates, the pharmacist‐managed service averted $141,277.34 in hospitalization costs and $10,183.76 in emergency department visit costs versus the nurse‐managed service and $95,579.08 in hospitalization costs and $5511.21 in emergency department costs compared with the usual care model.Conclusion. Pharmacist‐managed anticoagulation management services reduced the rates of anticoagulation‐related emergency department visits and hospitalizations, with significant financial impact. Based on results of this study, a collaborative clinic using pharmacists, nurses, and physicians may be the optimal structure for an anticoagulation management service, with these results verified in future prospective randomized studies.
Prognostic Factors and Morbidities After Completion Surgery in Patients Undergoing Initial Chemoradiation Therapy for Locally Advanced Cervical Cancer
Authors: Touboul Cyril , Uzan Catherine , Mauguen Audrey , Gouy Sebastien , Rey Annie , Pautier Patricia , Lhommé Catherine , Duvillard Pierre , Haie-Meder Christine , Morice Philippe 
Published: March 2010

Abstract

Learning Objectives
After completing this course, the reader will be able to: Rate the prognostic factors for overall survival in patients undergoing completion surgery after initial chemoradiation therapy (CRT) for locally advanced cervical cancer.In cervical cancer patients undergoing completion surgery, consider using laparoscopy to decrease the morbidity of the surgery.In cervical cancer patients undergoing completion surgery, use PET-CT imaging to improve detection of para-aortic involvement.
This article is available for continuing medical education credit at CME.TheOncologist.com

Purpose.
The aim of this study was to evaluate the prognostic factors and morbidities of patients undergoing completion surgery for locally advanced-stage cervical cancer after initial chemoradiation therapy (CRT).

Patients and Methods.
Patients fulfilling the following inclusion criteria were studied: stage IB2–IVA cervical carcinoma, tumor initially confined to the pelvic cavity on conventional imaging, pelvic external radiation therapy with delivery of 45 Gy to the pelvic cavity and concomitant chemotherapy (cisplatin, 40 mg/m2 per week) followed by uterovaginal brachytherapy, and completion surgery after the end of radiation therapy including at least a hysterectomy.

Results.
One-hundred fifty patients treated in 1998–2007 fulfilled the inclusion criteria. Prognostic factors for overall survival in the multivariate analysis were the presence and level of nodal spread (positive pelvic nodes alone: hazard ratio [HR], 2.03; positive para-aortic nodes: HR, 5.46; p &lt; .001) and the presence and size of residual disease (RD) in the cervix (p = .02). Thirty-seven (25%) patients had 55 postoperative complications. The risk for complications was higher with a radical hysterectomy (p = .04) and the presence of cervical RD (p = .01).

Conclusion.
In this series, the presence and size of RD and histologic nodal involvement were the strongest prognostic factors. Such results suggest that the survival of patients treated using CRT for locally advanced cervical cancer could potentially be enhanced by improving the rate of complete response in the irradiated area (cervix or pelvic nodes) and by initially detecting patients with para-aortic spread so that treatment could be adapted in such patients. The morbidity of completion surgery is high in this context.
Hypomanic Symptoms in Female Undergraduate Students Diagnosed with Unipolar Depression Based on Scores on the Hypomania Checklist
Authors: Richardson Thomas , Garavan Hugh 
Published: March 2010

Background:
A number of studies have documented high levels of hypomanic symptoms in those diagnosed with depression, suggesting a potential misdiagnosis of bipolar disorder as unipolar depression. Research suggests that undergraduate students have high levels of depression, but whether such misdiagnosis occurs in this population has not been examined. The aim of this study was therefore to examine levels of hypomania in undergraduate students reporting diagnosed depression.

Methods:
An international sample of undergraduate students completed the 32-item Hypomania Checklist (HCL-32). A cohort was analysed for this study, consisting of female undergraduate students reporting a formal diagnosis of depression (n=28).

Results:
Participants scored high on the HCL-32, with a mean total score of 19.9 (SD=5.4) out of 32. Overall, 85.7% (n=24) scored equal to or above the original cut off point of 14 suggested for bipolar II disorder.

Conclusions:
Two possible conclusions are suggested by this study. Firstly, there are high levels of hypomanic symptoms in undergraduate students diagnosed with depression, suggesting that a formal diagnosis of bipolar disorder should be pursued in those with high scores. Alternatively, the cut-off points previously suggested for the HCL-32 may not be accurate for use with undergraduate students.
Personality Traits in an Italian Sample: Relationship with Anxiety and Depression
Authors: Minelli Alessandra , Pedrini Laura , Magni Laura Rosa , Rotondo Alessandro 
Published: March 2010

Personality traits provide a description of individual emotional and cognitive processes that modulate thoughts, feelings and behaviour. Few studies have investigated the relationship of personality traits with depression and anxiety in the general Italian population. The aim of the present study was to replicate previous evidences about the association of personality traits with anxiety and depression in a general Italian population sample.We recruited 418 volunteers through different sources; such as university, newspaper advertisement, hospital, and elderly association. 327 subjects accepted to participate to the study and were screened with the Mini-International Neuropsychiatric Interview (M.I.N.I.) in order to assess DSM-IV Axis I disorders and with the Temperament and Character Inventory (TCI) in order to measure personality traits.Based on the assessment made by the MINI, the whole sample consisted of 266 (81%) subjects without and 61 subjects (19%) with life-time DSM-IV Axis I disorders. Volunteers with life-time anxiety and depressive disorders showed high scores in Harm Avoidance as well as low scores in Self-Directedness and in the Novelty Seeking subscale “Exploratory Excitability”.Our results support previous evidences showing that personality traits, in particular Harm Avoidance and Self-Directedness, could represent markers of vulnerability for depression and anxiety disorders.
Effect of Bio-Oss® Collagen and Collagen Matrix on Bone Formation
Authors: Wong R.W.K , Rabie A.B.M 
Published: March 2010

Objective:to compare the amount of new bone produced by Bio-Oss®Collagen to that produced by collagen matrixin vivo.Method:eighteen bone defects, 5mm by 10mm were created in the parietal bone of 9 New Zealand White rabbits. 6 defects were grafted with Bio-Oss®Collagen. 6 defects were grafted with collagen matrix alone (positive control) and 6 were left empty (negative control). Animals were killed on day 14 and the defects were dissected and prepared for histological assessment. Quantitative analysis of new bone formation was made on 100 sections (50 sections for each group) using image analysis.Results:A total of 339% more new bone was present in defects grafted with Bio-Oss®Collagen than those grafted with collagen matrix (positive control). No bone was formed in the negative control group.Conclusion:Bio-Oss®Collagen has the effect of stimulating new bone formation locally compared with collagen matrixin vivo. Bio-Oss®Collagen may be utilized as a bone graft material.
Unicompartmental Knee Resurfacing: Enlarged Tibio-Femoral Contact Area and Reduced Contact Stress Using Novel Patient-Derived Geometries
Authors: Steklov Nick , Slamin John , Srivastav Sudesh , D’Lima Darryl 
Published: March 2010

Advances in imaging technology and computer-assisted design (CAD) have recently enabled the introduction of patient-specific knee implant designs that hold the potential to improve functional performance on the basis of patient-specific geometries, namely a patient-specific sagittal and coronal curvature, as well as enhanced bone preservation. The objective of this study was to investigate the use of a novel implant design utilizing a patient specific sagittal J-curve on the femoral component combined with a novel constant, patient-derived femoral coronal curvature and to assess tibio-femoral contact area and contact stress on a femur matched curved tibial polyethylene insert.
Mean contact area and standard deviations were 81±5, 96±5 and 74±4 mm2 for the heel strike, toe off and mid-stance positions, respectively. Mean contact stress and standard deviations were 23.83±1.39, 23.27±1.14 and 20.78±0.54 MPa for the heel strike, toe off and mid-stance positions, respectively. Standard deviations of the measurements were small, not exceeding 6-7% confirming the consistency of loading conditions across different flexion angles. The results were comparable to those reported for standard, off-the-shelf fixed-bearing implants with paired femoral and tibial geometries. These data show that a constant coronal curvature can be applied to a patient-specific implant by measuring coronal curvatures across the femoral condyle in each patient and by deriving an average curvature. This novel approach combines unique benefits of patient-specific geometry with proven design concepts for minimizing polyethylene wear.