bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Screening for Catalytic Promiscuity in 4‐Oxalocrotonate Tautomerase: Enamine Formation and Aldolase Activity
Authors: Zandvoort Ellen , Baas Bert‐Jan , Quax Wim J. , Poelarends Gerrit J. 
Published: February 2011

AbstractThe enzyme 4‐oxalocrotonate tautomerase (4‐OT) is part of a catabolic pathway for aromatic hydrocarbons in Pseudomonas putida mt‐2, where it catalyzes the conversion of 2‐hydroxy‐2,4‐hexadienedioate (1) to 2‐oxo‐3‐hexenedioate (2). 4‐OT is a member of the tautomerase superfamily, a group of homologous proteins that are characterized by a β‐α‐β structural fold and a catalytic amino‐terminal proline. In the mechanism of 4‐OT, Pro1 is a general base that abstracts the 2‐hydroxyl proton of 1 for delivery to the C‐5 position to yield 2. Here, 4‐OT was explored for nucleophilic catalysis based on the mechanistic reasoning that its Pro1 residue has the correct protonation state (pKa∼6.4) to be able to act as a nucleophile at pH 7.3. By using inhibition studies and mass spectrometry experiments it was first demonstrated that 4‐OT can use Pro1 as a nucleophile to form an imine/enamine with various aldehyde and ketone compounds. The chemical potential of the smallest enamine (generated from acetaldehyde) was then explored for further reactions by using a small set of selected electrophiles. This systematic screening approach led to the discovery of a new promiscuous activity in wild‐type 4‐OT: the enzyme catalyzes the aldol condensation of acetaldehyde with benzaldehyde to form cinnamaldehyde. This low‐level aldolase activity can be improved 16‐fold with a single point mutation (L8R) in 4‐OT's active site. The proposed mechanism of the reaction mimicks that used by natural class‐I aldolases and designed catalytic aldolase antibodies. An important difference, however, is that these natural and designed aldolases use the primary amine of a lysine residue to form enamines with carbonyl substrates, whereas 4‐OT uses the secondary amine of an active‐site proline as the nucleophile catalyst. Further systematic screening of 4‐OT and related proline‐based biocatalysts might prove to be a useful approach to discover new promiscuous carbonyl transformation activities that could be exploited to develop new biocatalysts for carbon‐carbon bond formation.
Partial least squares discrimination with heterogeneous covariance structures
Authors: Liu Yushu , Rayens William , Andersen Anders , Smith Charles 
Published: February 2011

AbstractBarker and Rayens 1 argued that partial least squares (PLS) is to be preferred over principal components analysis (PCA) when linear discrimination is the goal and dimension reduction is required as a first step. In particular, it is now known that when PLS is used as the dimension reduction tool, information involving Fisher's among‐groups sums‐of‐squares and cross‐products matrix is embedded in the structures extracted to achieve that reduction. Liu and Rayens 2 followed up with a formal proof for the superiority of PLS over PCA in the two‐group case (with respect to formal misclassification probabilities) and pointed to a subclass of oriented PLS (OrPLS) 3 techniques that would always produce a lower misclassification rate than would PLS, for the two‐group problem with like covariance matrices. This paper addresses the situation where these within‐groups covariances are potentially not the same, and hence a single reduction step followed by linear discrimination may not be appropriate. A variety of techniques are compared by way of a large‐scale simulation study, and a version of the ridged subclass studied by Liu and Rayens 2 emerges as the recommended approach from among those studied. An application aimed at distinguishing asymptomatic women at risk for Alzheimer's disease from women not at risk, based on functional magnetic resonance imaging (fMRI) scans, is also presented. Copyright © 2011 John Wiley & Sons, Ltd.
Mechanistic Insight into Stereoselective Carbolithiation
Authors: Gessner Viktoria H. , Koller Stephan G. , Strohmann Carsten , Hogan Anne‐Marie , O'Shea Donal F. 
Published: February 2011

AbstractThis article addresses the mechanistic features of asymmetric carbolithiation of β‐methylstyrenes. While often the presence of functional groups is required to obtain high enantioselectivities in carbolithiation reactions, simple β‐methylstyrene also gives high selectivities in (−)‐sparteine‐mediated addition of alkyl lithium compounds. Computational studies on the carbolithiation of β‐methylstyrene with (−)‐sparteine show that the observed selectivities are the result of repulsion effects in the diastereomeric transition states between the (−)‐sparteine⋅alkyl lithium adduct and the β‐methylstyrene, upon approximation of the two reactants. In contrast, for the ortho‐amino β‐methylstyrene (E)‐benzyl(2‐propenylphenyl)amine (4) X‐ray structure analyses of intermediate lithium amides indicate a carbolithiation mechanism in which one side of the double bond is shielded by the amide moiety, leaving only one side free for approach of the chiral alkyl lithium adduct.
Influence of the Counterion on the Synthesis of ZnO Mesocrystals under Solvothermal Conditions
Authors: Distaso Monica , Klupp Taylor Robin N. , Taccardi Nicola , Wasserscheid Peter , Peukert Wolfgang 
Published: February 2011

AbstractPolymers and coordinating solvents have been shown to serve as templating agents to assist the precipitation of ZnO nanoparticles and address their morphology. In this work we show for the first time that a difference in the coordination strength between the polymer (poly‐N‐vinylpyrrolidone (PVP)) and the two ZnII precursor salts (nitrate and acetate) is able to promote or suppress the formation of mesocrystalline structures and even more importantly to tune their three‐dimensional organization. On the basis of FTIR and 13C NMR spectroscopic studies, we propose that not only the polymer (PVP) but also the solvent (DMF) play a key role as directing agents.
ChemInform Abstract: K2B12F12: A Rare A2X Structure for an Ionic Compound at Ambient Conditions.
Authors: Peryshkov Dmitry V. , Strauss Steven H. 
Published: February 2011

AbstractThe crystal structures of K2B12F12 (I) and Cs2(H2O)B12F12 (II) are determined by single crystal XRD.
ChemInform Abstract: Cocrystallization of Octahedral and Icosahedral Fluoroanions in K3(AsF6)(B12F12) and Cs3(AsF6)(B12F12). Rare Examples of Salts Containing Fluoroanions with Different Shapes and Charges.
Authors: Peryshkov Dmitry V. , Goreshnik Evgeny , Mazej Zoran , Strauss Steven H. 
Published: February 2011

AbstractSingle crystals of the title compounds are prepared from solutions of KAsF6 or CsAsF6 and Cs2B12F12 in anhydrous HF at 20—25 °C.
ChemInform Abstract: In—CuInS2 Nanocomposite Film Prepared by Pulsed Laser Deposition Using a Single Source Precursor.
Authors: Bensch Wolfgang , Quiroga‐Gonzalez Enrique , Kienle Lorenz , Duppel Viola , Lee Doh‐Kwon , Janek Juergen 
Published: February 2011

Abstract[C13H28N2] 5Cu2.1In17.9S33 ·17H2O is synthesized from a mixture of CuS, In, S, 4,4′‐trimethylenedipiperidine, H2O, and ethyleneglycol (autoclave, 190 °C, 5 d, <90% yield) and used as a precursor for the preparation of the title film by pulsed laser deposition.
ChemInform Abstract: Ba3MIIITiMVO9 (MIII: Fe, Ga, Y, Lu; MV: Nb, Ta, Sb) Perovskite Oxides: Synthesis, Structure and Dielectric Properties.
Authors: Joy Joby E. , Atamanik Eric , Mani Rohini , Nag Abanti , Tiwari R. M. , Thangadurai V. , Gopalakrishnan J. 
Published: February 2011

AbstractThe title compounds are prepared by solid state reaction of stoichiometric mixtures of BaCO3, FeC2O4, Ga2O3, Y2O3, Lu2O3, TiO2, Nb2O5, Ta2O5, and Sb2O3 (1100—1300 °C, 24—48 h) and characterized by powder XRD and dielectric measurements.
ChemInform Abstract: Ternary Heterostructured Nanoparticle Tubes: A Dual Catalyst and Its Synergistic Enhancement Effects for O2/H2O2 Reduction.
Authors: Cui Chun‐Hua , Li Hui‐Hui , Yu Jin‐Wen , Gao Min‐Rui , Yu Shu‐Hong 
Published: February 2011

AbstractA Pd‐Au/CuO@Cu heterostructured nanoparticle tube catalyst is synthesized by a one‐step electrodeposition route onto an anodic aluminium oxide template in anhydrous DMSO, and characterized by powder XRD, SEM, TEM, XPS, and cyclic voltammetry.
ChemInform Abstract: A New Potassium Rare Earth Oxyborate K2La2(BO3)2O.
Authors: Zeng Q. D. , Li R. K. 
Published: February 2011

AbstractPowder samples of K2Ln2(BO3)2O (Ln: La, Nd, Sm, Eu) are prepared by solid state reaction of K2CO3, Ln2O3, and H3BO3 (Pt crucible, 840—900 °C, 48 h).
ChemInform Abstract: A Two‐Dimensional Topological Structure and a Series of Corresponding Plate‐Like Ln(IO3)3(H2O)·H2O (Ln: Nd, Eu, Gd, Tb, Dy) Nanomaterials: Synthesis, Structures and Properties.
Authors: Chai Wenxiang , Lin Jian , Song Li , Shu Kangying , Qin Laishun , Shi Hongsheng , Guo Jiayu 
Published: February 2011

AbstractThe title nanomaterials are precipitated from aqueous solutions of Ln(NO3)3 (Ln: Nd, Eu, Gd, Tb, Dy) and KIO3 (293 K, about 72% yield).
ChemInform Abstract: Syntheses and Crystal Structures of a Series of Alkaline Earth Vanadium Selenites and Tellurites.
Authors: Zhang Su‐Yun , Hu Chun‐Li , Sun Chuan‐Fu , Mao Jiang‐Gao 
Published: February 2011

AbstractAs revealed by single crystal XRD compound (IV) crystallizes in the space group Pnma with Z = 4 and features a three‐dimensional anionic framework composed of VO6 octahedra bridged by SeO3 polyhedra.
ChemInform Abstract: Design of Tri‐Substituted Dodecatungstosilicate from a Trilacunary Silicotungstate by Insertion of Manganese Ions of [Mn3(μ3‐O)(2‐Cl‐benzoato)6 (py)3]: Synthesis, Structure, Redox and Magnetic Studies.
Authors: Dutta Daipayan , Jana Atish D. , Debnath Mainak , Mostafa Golam , Clerac Rodolphe , Tojal Javier G. , Ali Mahammad 
Published: February 2011

AbstractThe new MnII/MnIII mixed tricapped Keggin polyoxometalate (IV) crystallizes in the trigonal space group R$\bar 3$ with Z = 3 (single crystal XRD).
ChemInform Abstract: Enantioselective Conjugate Addition of Boronic Acids to Enones Catalyzed by O‐Monoacyltartaric Acids.
Authors: Sugiura Masaharu , Tokudomi Mirai , Nakajima Makoto 
Published: February 2011

AbstractUse of tartaric acid mono‐3,5‐di(tert‐butyl)benzoate as chiral organocatalyst furnishes the addition products (III) and (V) in moderate yields with good enantioselectivity.
ChemInform Abstract: Highly Efficient Direct Asymmetric Aldol Reactions Catalyzed by a Prolinethioamide Derivative in Aqueous Media.
Authors: Wang Bing , Liu Xin‐wang , Liu Ling‐yan , Chang Wei‐xing , Li Jing 
Published: February 2011

AbstractA new L‐prolinethioamide derivative is prepared and employed in the direct asymmetric aldol reaction of acetone with aromatic aldehydes.
ChemInform Abstract: Easy Access to α‐Bromoketones and Epoxides from vic‐Dibromides under Aqueous Conditions.
Authors: Patil Rajendra D. , Adimurthy Subbarayappa , Ranu Brindaban C. 
Published: February 2011

AbstractThe described procedure does not work with aliphatic substrates and cyclic 1,2‐dibromides.
ChemInform Abstract: Designer μ‐Oxo‐Bridged Hypervalent Iodine(III) Organocatalysts for Greener Oxidations.
Authors: Dohi Toshifumi , Takenaga Naoko , Fukushima Kei‐ichiro , Uchiyama Teruyoshi , Kato Daishi , Shiro Motoo , Fujioka Hiromichi , Kita Yasuyuki 
Published: February 2011

AbstractOxidative spirocyclization of a variety of amides is achieved using a novel bis(iodoarene) precatalyst and peracetic acid as environment‐friendly reoxidant.
ChemInform Abstract: Rhodium‐Catalyzed Domino Heterocyclization and [(3 + 2) + 2] Carbocyclization: Construction of Fused Tricycloheptadienes.
Authors: Zhao Wanxiang , Zhang Junliang 
Published: February 2011

AbstractThe first examples of Rh(I)‐catalyzed two‐component tandem heterocyclization and formal [(3 + 2) + 2] carbocyclization reactions of readily available diyne‐enone and alkyne furnishing tricycloheptadienes are given.
ChemInform Abstract: Pd/Cu‐Catalyzed Direct Alkenylation of Azole Heterocycles with Alkenyl Halides.
Authors: Sahnoun Sophian , Messaoudi Samir , Brion Jean‐Daniel , Alami Mouad 
Published: February 2011

AbstractThe use of alkenyl bromides as partners in the direct Pd—Cu‐catalyzed C—H alkenylation of a wide range of heterocycles is described.
ChemInform Abstract: Highly Selective Claisen—Schmidt Condensation Catalyzed by Silica Chloride under Solvent‐Free Reaction Conditions.
Authors: Hazarkhani Hassan , Kumar Pradeep , Kondiram Kadam Sachin , Gadwal Ikhlas M. Shafi 
Published: February 2011

AbstractA new application of silica chloride as an efficient catalyst for the highly selective large‐scale synthesis of bisarylidene cycloalkanones and chalcones is described.
ChemInform Abstract: Enantioselective Hydroformylation of N‐Vinyl Carboxamides, Allyl Carbamates, and Allyl Ethers Using Chiral Diazaphospholane Ligands.
Authors: McDonald Richard I. , Wong Gene W. , Neupane Ram P. , Stahl Shannon S. , Landis Clark R. 
Published: February 2011

AbstractThe rhodium complex of the diazaphospholane ligand BAZ catalyzes asymmetric hydroformylations of N‐vinyl carboxamides, allyl ethers, and allyl carbamates.
ChemInform Abstract: Oxidation of Secondary Alkanols with the System Cerium Ammonium Nitrate—Lithium Bromide into Ketones, α‐Bromo Ketones, and α,α′‐Dibromo Ketones.
Authors: Nikishin G. I. , Sokova L. L. , Kapustina N. I. 
Published: February 2011

AbstractThe selectivity of the oxidation reaction depends only on the molar ratio of the reagents.
ChemInform Abstract: Pd‐Catalyzed Allylation of CH Acids under Phase‐Transfer Conditions.
Authors: Vasil'ev A. A. , Lyubimov S. E. , Serebryakov E. P. , Davankov V. A. , Struchkova M. I. , Zlotin S. G. 
Published: February 2011

AbstractA range of phosphorous ligands is used for the allylation of various malonates or ethyl cyanoacetate.
ChemInform Abstract: Synthesis and Characterization of Polymer Anchored Cu(II) Complexes: Heterogeneous Catalysts for Preparation of Diaryl Ethers.
Authors: Islam Manirul , Mondal Sanchita , Mobarak Manir , Singha Roy Anupam , Mondal Paromita , Hossain Dildar 
Published: February 2011

AbstractSynthesis, characterization, and application of novel reusable catalysts (I) in Ullmann diaryl ether coupling is described.
ChemInform Abstract: Direct Carboxylation of Arenes and Halobenzenes with CO2 by the Combined Use of AlBr3 and R3SiCl.
Authors: Nemoto Koji , Yoshida Hiroki , Egusa Naoki , Morohashi Naoya , Hattori Tetsutaro 
Published: February 2011

AbstractIt allows and efficient and regioselective access to a number of aromatic carboxylic acids.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Cross Coupling of Aromatic Aldehydes with Baylis—Hillman Bromides: An Easy Access to α‐Arylidene‐γ‐keto Esters.
Authors: Singh Pankaj , Singh Santosh , Rai Vijai K. , Yadav Lal Dhar S. 
Published: February 2011

AbstractThe first efficient NHC‐catalyzed intermolecular cross‐coupling of aromatic aldehydes with Baylis—Hillman bromides (14 examples) is developed.
ChemInform Abstract: Enantioselective Michael Reaction of α‐Alkyl‐β‐keto Esters and Enones under Multifunctional Catalysis.
Authors: Yang Juanjuan , Li Wenjun , Jin Zhichao , Liang Xinmiao , Ye Jinxing 
Published: February 2011

AbstractIn most cases, the products are formed with excellent diastereoselectivity and high enantioselectivity.
ChemInform Abstract: Indium(III) Chloride: An Efficient Catalyst for the Synthesis of Amidoalkyl Naphthols
Authors: Chavan Neelam L. , Naik Prajakta N. , Nayak Sandip K. , Kusurkar Radhika S. 
Published: February 2011

Abstractvia microwave‐accelerated three‐component condensation of β‐naphthol, aromatic aldehydes and acetamide or urea
ChemInform Abstract: Tandem Pd‐Catalyzed Carbonylation and Intramolecular Vinyl Allene Diels—Alder Reaction Toward Galiellalactone Analogues.
Authors: Gidloef Ritha , Johansson Martin , Sterner Olov 
Published: February 2011

AbstractA sequence is developed to yield bicyclic products of type (V) together with undesired cyclopentenones.
ChemInform Abstract: m‐CPBA/TFA: An Efficient Nonmetallic Reagent for Oxidative Coupling of 1,2‐Diarylethylenes.
Authors: Wang Kailiang , Hu Yanna , Wu Meng , Li Zheng , Liu Zhihui , Su Bo , Yu Ao , Liu Yu , Wang Qingmin 
Published: February 2011

AbstractIn the presence of an optimized amount of MCPBA, (E)‐ or (Z)‐bis(dialkoxyaryl)ethenes undergo an intramolecular coupling reaction in TFA as solvent to give phenanthrenes.
ChemInform Abstract: Generation of Benzyne from Benzoic Acid Using C—H Activation.
Authors: Cant Alastair A. , Roberts Lee , Greaney Michael F. 
Published: February 2011

AbstractThe palladium‐catalyzed decarboxylation of para‐ and meta‐benzoic acids gives rise to intermediate Pd‐bound arynes, which undergo trimerization to afford 2,6,11‐trisubstituted triphenylenes (II).
ChemInform Abstract: Gold‐Catalyzed Cascade Cyclization—Oxidative Alkynylation of Allenoates.
Authors: Hopkinson Matthew N. , Ross Jonathan E. , Giuffredi Guy T. , Gee Antony D. , Gouverneur Veronique 
Published: February 2011

Abstractβ‐Alkynyl‐γ‐butenolides are prepared directly from allenoates and alkynes without preactivation.
ChemInform Abstract: Nucleophilic Addition to Acetylenes in Superbasic Catalytic Systems. Part 17. Vinyl Ethers with Furyl and Cycloacetal Fragments: Synthesis and Structure.
Authors: Oparina L. A. , Vysotskaya O. V. , Stepanov A. V. , Gusarova N. K. , Chernyshev K. A. , Krivdin L. B. , Trofimov B. A. 
Published: February 2011

AbstractThe reaction of furfural with glycerol leads to a mixture of alcohols (II) and (III), which reacts readily with acetylene to afford a mixture of corresponding vinyl ethers in high yield.
ChemInform Abstract: New Synthesis of 3‐Trifluoromethylpyrroles by Condensation of Mesoionic 4‐Trifluoroacetyl‐1,3‐oxazolium‐5‐olates with Phosphorus Ylides.
Authors: Saijo Ryosuke , Hagimoto Yuri , Kawase Masami 
Published: February 2011

AbstractThe procedures allow the approach to various highly substituted pyrrole structures.
ChemInform Abstract: Preparation of 4,6‐Diarylindazole Derivatives in Ionic Liquid under Solvent‐Free Conditions.
Authors: Safaei‐Ghomi Javad , Taheri Mahdi , Ghasemzadeh Mohammad Ali 
Published: February 2011

AbstractIn the presented synthesis the use of phenylhydrazine instead of hydrazine is also effective and leads to products of type (IV).
ChemInform Abstract: Palladium‐ and Nickel‐Catalyzed Direct Alkylation of Azoles with Unactivated Alkyl Bromides and Chlorides.
Authors: Yao Tomoyuki , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: February 2011

AbstractTitle reaction tolerates a range of functional groups like ethers, silyl ethers, esters, olefins and acetals.
ChemInform Abstract: 5‐Amino‐3,4‐dihydro‐2H‐1,2,4‐triazole‐3‐thiones. Synthesis and Chemosensor Properties.
Authors: Tolpygin I. E. , Shepelenko E. N. , Borodkin G. S. , Dubonosov A. D. , Bren' V. A. , Minkin V. I. 
Published: February 2011

AbstractThe reaction of thiosemicarbazides (III) with aroyl isothiocyanates yields substituted 1,2‐bis(thiocarbamoyl)hydrazines (IX), which readily cyclize to hitherto unknown triazole‐3‐thione derivatives (V).
ChemInform Abstract: Aqua Mediated Synthesis of 2‐Amino‐6‐benzothiazol‐2‐ylsulfanyl‐chromenes and Its in vitro Study, Explanation of the Structure—Activity Relationships (SARs) as Antibacterial Agent.
Authors: Kidwai Mazaahir , Poddar Roona , Bhardwaj Saurav , Singh Satendra , Luthra Pratibha Mehta 
Published: February 2011

AbstractTitle compounds (VI) as well as related benzimidazol‐2‐ylsulfanyl‐chromenes (XI) are synthesized by one‐pot multi‐component reactions under microwave irradiation.
ChemInform Abstract: Ytterbium Triflate Catalyzed Synthesis of Alkoxy‐Substituted Donor—Acceptor Cyclobutanes and Their Formal [4 + 2] Cycloaddition with Imines: Stereoselective Synthesis of Piperidines.
Authors: Moustafa Mahmoud M. Abd Rabo , Pagenkopf Brian L. 
Published: February 2011

AbstractA novel synthesis of substituted and fused donor‐acceptor cyclobutane diesters and cyclobutanes with carbon‐donating groups is developed.
ChemInform Abstract: A General Approach to (Trifluoromethoxy)pyridines: First X‐Ray Structure Determinations and Quantum Chemistry Studies.
Authors: Manteau Baptiste , Genix Pierre , Brelot Lydia , Vors Jean‐Pierre , Pazenok Sergiy , Giornal Florence , Leuenberger Charlotte , Leroux Frederic R. 
Published: February 2011

AbstractA general, efficient and large‐scale route to (trifluoromethoxy)pyridines is reported.
ChemInform Abstract: Efficient Synthesis of Polyhydroquinolines via the Hantzsch Reaction Using Iron Loaded Mesoporous Materials.
Authors: Heravi Majid M. , Hosseini Mariam , Oskooie Hossein A. , Baghernejad Bita , Farzaneh F. 
Published: February 2011

AbstractThe one‐pot, four‐component reaction proceeds smoothly in the presence of Fe‐Al‐MCM‐41 as recyclable heterogeneous catalyst.
ChemInform Abstract: Catalytic Enantioselective Friedlaender Condensations: Facile Access to Quinolines with Remote Stereogenic Centers.
Authors: Li Le , Seidel Daniel 
Published: February 2011

AbstractThe reaction of 4‐substituted cyclohexanones with various o‐aminobenzaldehydes affords acridine derivatives in high yields and enantioselectivities.
ChemInform Abstract: Computer‐Based Drug Design, Synthesis and Biological Evaluation of New Pyrimidinone Derivatives Linked to Arylpiperazine and 2′‐Carbethoxy‐biphenylmethyl Moieties as α1‐Adrenoceptor Antagonists and Angiotensin II AT1 Receptor Antagonists.
Authors: Ismail M. A. H. , El Ella D. A. Abou , Abouzid K. A. M. , Al‐Ansary G. H. A. 
Published: February 2011

AbstractA novel series of pyrimidine derivatives of type (I) ‐ (III) is designed, synthesized, and evaluated for in vivo hypotensive effects.
ChemInform Abstract: New Octahydroquinazoline Derivatives: Synthesis and Hypotensive Activity.
Authors: El‐Sabbagh O. I. , Shabaan Mohamed A. , Kadry Hanan H. , Al‐Din Ehab Saad 
Published: February 2011

AbstractA variety of new octahydroquinaolinone derivatives is synthesized starting with the Mannich reaction of aminocyclohexenone (I).
ChemInform Abstract: Synthesis and in vitro Biological Evaluation of Some Quinazolin Substituted Pyrazoles, Pyrazolones and 1,3,4‐Oxadiazoles.
Authors: Sah Pramilla , Kaul Vasudha 
Published: February 2011

AbstractThe new compounds (VI), (VIII), and (X) are screened for their antibacterial and insecticidal activity.
ChemInform Abstract: β,β‐Disilylated Sulfones as Versatile Building Blocks in Organic Chemistry — A New Sulfonyl Carbanion Transmetalation.
Authors: Puget Bertrand , Jahn Ullrich 
Published: February 2011

AbstractSo far, unknown bissilylated sulfone (III) undergoes an unprecedented, initial ortho‐metalation to an allyllithium at low temperature, which transmetalates quantitatively to corresponding α‐sulfonyl organo‐lithium compound.
ChemInform Abstract: Hydrosilylation—Metathesis Sequence Leading to 1‐Silaindenes.
Authors: Matsuda Takanori , Yamaguchi Yoshiyuki , Ishida Naoki , Murakami Masahiro 
Published: February 2011

AbstractA trans‐hydrosilylation and a ring‐closing metathesis is utilized to synthesize the title compounds.
ChemInform Abstract: Use of Phosphonyl Carbanions in the Synthesis of Antiinflammatory Active Phosphorus‐Containing Fused Heterocycles and Relevance Phosphonates.
Authors: Abdou Wafaa M. , Kamel Azza A. , Shaddy Abeer A. 
Published: February 2011

AbstractA variety of phosphorus‐containing bicyclic 5,5‐ and 5,6‐membered systems are synthesized by Horner—Emmons reactions of 2‐acetylfuran (I) or ‐thiophene (V).
ChemInform Abstract: Briarenolide D, a New Hydroperoxybriarane Diterpenoid from a Cultured Octocoral Briareum sp.
Authors: Sung Ping‐Jyun , Lin Mei‐Ru , Chiang Michael Y. , Huang I‐Chu , Syu Siou‐Ming , Fang Lee‐Shing , Wang Wei‐Hsien , Sheu Jyh‐Horng 
Published: February 2011

AbstractPreliminary studies concerning cytotoxicity do not reveal any positive effects.
ChemInform Abstract: Design, Synthesis and in vivo Hypoglycemic Activity of Tetrazole‐Bearing N‐Glycosides as SGLT2 Inhibitors.
Authors: Gao Y. L. , Zhao G. L. , Liu W. , Shao H. , Wang Y. L. , Xu W. R. , Tang L. D. , Wang J. W. 
Published: February 2011

AbstractCompounds (I) show significant in vivo biological activity as SGLT2 inhibitors and are more potent than the positive control Dapagliflozin.