bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neural correlates of tinnitus duration and Distress: A positron emission tomography study
Authors: Schecklmann Martin , Landgrebe Michael , Poeppl Timm B. , Kreuzer Peter , Männer Peter , Marienhagen Jörg , Wack David S. , Kleinjung Tobias , Hajak Göran , Langguth Berthold 
Published: October 2011

AbstractCerebral 18F‐deoxyglucose positron emission tomography (FDG‐PET) has shown altered auditory pathway activity in tinnitus. However, the corresponding studies involved only small samples and analyses were restricted to the auditory cortex in most studies. Evidence is growing that also limbic, frontal, and parietal areas are involved in the pathophysiology of chronic tinnitus. These regions are considered to mediate perceptual, attentional, and emotional processes. Thus, the aim of the present study was the systematic evaluation of metabolic brain activity in a large sample of tinnitus patients. Ninety one patients with chronic tinnitus underwent FDG‐PET. The effects of tinnitus severity (assessed by a tinnitus questionnaire score), duration and laterality were evaluated with statistical parametric mapping (SPM) in whole brain analyses. In addition, region of interest analyses were performed for primary auditory areas. Tinnitus duration correlated positively with brain metabolism in right inferior frontal, right ventro‐medial prefrontal, and right posterior cingulate cortex. Tinnitus distress correlated positively with activation of left and right posterior inferior temporal gyrus as well as left and right posterior parahippocampal–hippocampal interface. Region of interest analysis demonstrated an overactivation of left in contrast to right Heschl's gyrus independently from tinnitus laterality and anatomical hemispheric differences. Tinnitus duration and distress were associated with areas involved in attentional and emotional processing. This is in line with recent findings indicating the relevance of higher order areas in the pathophysiology of tinnitus. Earlier results of asymmetric activation of the auditory cortices in tinnitus were confirmed, i.e., left‐sided overactivation was found independently from tinnitus laterality. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
Diffusion tensor imaging metrics of the corpus callosum in relation to bimanual coordination: Effect of task complexity and sensory feedback
Authors: Gooijers Jolien , Caeyenberghs Karen , Sisti Helene M. , Geurts Monique , Heitger Marcus H. , Leemans Alexander , Swinnen Stephan P. 
Published: October 2011

AbstractWhen manipulating objects with both hands, the corpus callosum (CC) is of paramount importance for interhemispheric information exchange. Hence, CC damage results in impaired bimanual performance. Here, healthy young adults performed a complex bimanual dial rotation task with or without augmented visual feedback and according to five interhand frequency ratios (1:1, 1:3, 2:3, 3:1, 3:2). The relation between bimanual task performance and microstructural properties of seven CC subregions (i.e., prefrontal, premotor/supplementary motor, primary motor, primary sensory, occipital, parietal, and temporal) was studied by means of diffusion tensor imaging (DTI). Findings revealed that bimanual coordination deteriorated in the absence as compared to the presence of augmented visual feedback. Simple frequency ratios (1:1) were performed better than the multifrequency ratios (non 1:1). Moreover, performance was more accurate when the preferred hand (1:3–2:3) as compared to the nonpreferred hand (3:1–3:2) moved faster and during noninteger (2:3–3:2) as compared to integer frequency ratios (1:3–3:1). DTI findings demonstrated that bimanual task performance in the absence of augmented visual feedback was significantly related to the microstructural properties of the primary motor and occipital region of the CC, suggesting that white matter microstructure is associated with the ability to perform bimanual coordination patterns in young adults. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
The contribution of working memory to divided attention
Authors: Santangelo Valerio , Macaluso Emiliano 
Published: October 2011

AbstractPrevious studies have indicated that increasing working memory (WM) load can affect the attentional selection of signals originating from one object/location. Here we assessed whether WM load affects also the selection of multiple objects/locations (divided attention). Participants monitored either two object‐categories (vs. one category; object‐based divided attention) or two locations (vs. one location; space‐based divided attention) while maintaining in WM either a variable number of objects (object‐based WM load) or locations (space‐based WM load). Behavioural results showed that WM load affected attentional performance irrespective of divided or focused attention. However, fMRI results showed that the activity associated with object‐based divided attention increased linearly with increasing object‐based WM load in the left and right intraparietal sulcus (IPS); while, in the same areas, activity associated with space‐based divided attention was not affected by any type of WM load. These findings support the hypothesis that WM contributes to the maintenance of resource‐demanding attentional sets in a domain‐specific manner. Moreover, the dissociable impact of WM load on performance and brain activity suggests that increased IPS activation reflects a recruitment of additional, domain‐specific processing resources that enable dual‐task performance under conditions of high WM load and high attentional demand. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
Superficial lateral sural artery free flap for intraoral reconstruction: Anatomic study and clinical implications
Authors: Wolff Klaus‐Dietrich , Bauer Florian , Kunz Sebastian , Mitchell David Andrew , Kesting Marco Rainer 
Published: October 2011

AbstractBackgroundA posterolateral calf free flap is anatomically assessed and its usefulness for intraoral reconstruction is described.MethodsRecords of 42 cadaver dissections including anatomic parameters of the superficial lateral sural artery serving as pedicle were analyzed. Data of 20 patients with primary oral cancer who underwent reconstructions with posterolateral calf free flaps are presented.ResultsThe superficial lateral sural artery was present in 36 of 42 of all cadavers (85.8%). In all, 25 specimens of 36 were suitable as flaps (69.4%). It originated from the lateral sural and the popliteal artery (31% vs 69%). It was accompanied by 1 vein (40.5%) or 2 veins (59.5%). The artery pierced the crural fascia on average 3 cm lateral to the midline and 0 to 12 cm below the fibular head. Eight patients had inadequate superficial lateral sural vessels and were reconstructed by peroneal perforator flaps. One flap was lost.ConclusionsCutaneous flaps from the posterolateral calf can be a useful alternative for reconstruction of moderate sized defects with minimal donor site morbidity. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Surgical management of sinonasal hemangiopericytomas: A case series
Authors: Gomez–Rivera Fernando , Fakhri Samer , Williams Michelle D. , Hanna Ehab Y. , Kupferman Michael E. 
Published: October 2011

AbstractBackgroundSinonasal hemangiopericytomas are rare low‐grade sarcomas. The role of endoscopic management has not been adequately studied.MethodsThis study was conducted through retrospective medical chart review of patients seen with sinonasal hemangiopericytomas at 2 institutions over a 19‐year period. Demographic, clinicopathological, and surgical information was analyzed with descriptive statistics.ResultsThirteen patients with a diagnosis of sinonasal hemangiopericytomas were treated. The most common symptoms were obstruction (69%) and epistaxis (35%). All tumors were localized in the nasal cavity, and half had extension to 1 or more sinuses. Resection was performed endoscopically in 6 patients. Median intraoperative blood loss was 500 mL; median operative time was 165 minutes. Two patients received postoperative radiation. There were no recurrences with a median follow‐up of 25 months. Three patients presented with recurrences, 2 local and 1 distant, up to 13 years after primary tumor removal.ConclusionSurgery for sinonasal hemangiopericytomas can be challenging; both endoscopic and open approaches may be used to treat these highly vascular tumors. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
An Experimental Study to Evaluate the Effect of Ambient Temperature during Manual Lifting and Design of Optimal Task Parameters
Authors: Singh Ravindra Pratap , Batish Ajay , Singh T. P. , Bhattacharya Anirban 
Published: October 2011

AbstractIn the present study, the effect of lifting task parameters on the heart rate and oxygen uptake of workers during manual lifting tasks in different ambient conditions was evaluated. The experiments conducted in two different temperature conditions showed a significantly higher oxygen uptake and heart rate in colder conditions as compared to warmer conditions. Three other factors, namely, load, lifting frequency, and vertical distance were found to significant affect the responses. Various combinations of significant factors were used to calculate oxygen uptake and heart rate. These were then compared with the safe limits as per the maximum aerobic capacity of workers. Based on these comparisons, the safe combinations were identified that can be used to design lifting tasks in varied ambient conditions. The study further concluded that lifting tasks performed in winter should have different relaxation or fatigue allowances built into the cycle time of the task to compensate for higher exertion. © 2011 Wiley Periodicals, Inc.
Endoplasmic reticulum‐specific BH3‐only protein BNIP1 induces mitochondrial fragmentation in a Bcl‐2‐ and Drp1‐dependent manner
Authors: Ryu Seung‐Wook , Choi Kyungsun , Yoon Jonghee , Kim Sunchang , Choi Chulhee 
Published: October 2011

AbstractBcl‐2/adenovirus E1B 19‐kDa interacting protein 1 (BNIP1), which is predominantly localized to the endoplasmic reticulum (ER), is a pro‐apoptotic Bcl‐2 homology domain 3 (BH3)‐only protein. Here, we show that the expression of BNIP1 induced not only a highly interconnected ER network but also mitochondrial fragmentation in a BH3 domain‐dependent manner. Functional analysis demonstrated that BNIP1 expression increased dynamin‐related protein 1 (Drp1) expression followed by the mitochondrial translocation of Drp1 and subsequent mitochondrial fission. Both BNIP1‐induced mitochondrial fission and the translocation of Drp1 were abrogated by Bcl‐2 overexpression. These results collectively indicate that ER‐specific BNIP1 plays an important role in mitochondrial dynamics by modulating the mitochondrial fission protein Drp1 in a BH3 domain‐dependent fashion. J. Cell. Physiol. 227: 3027–3035, 2012. © 2011 Wiley Periodicals, Inc.
Microanatomy of passerine hard‐cornified tissues: Beak and claw structure of the black‐capped chickadee (Poecile atricapillus)
Authors: Van Hemert Caroline , Handel Colleen M. , Blake John E. , Swor, Rhonda M. , O'Hara Todd M. 
Published: October 2011

AbstractThe microanatomy of healthy beaks and claws in passerine birds has not been well described in the literature, despite the importance of these structures in avian life. Histological processing of hard‐cornified tissues is notoriously challenging and only a few reports on effective techniques have been published. An emerging epizootic of beak deformities among wild birds in Alaska and the Pacific Northwest region of North America recently highlighted the need for additional baseline information about avian hard‐cornified structures. In this study, we examine the beak and claw of the Black‐capped Chickadee (Poecile atricapillus), a common North American passerine that is affected by what has been described as “avian keratin disorder.” We use light and scanning electron microscopy and high‐magnification radiography to document the healthy microanatomy of these tissues and identify features of functional importance. We also describe detailed methods for histological processing of avian hard‐cornified structures and discuss the utility of special stains. Results from this study will assist in future research on the functional anatomy and pathology of hard‐cornified structures and will provide a necessary reference for ongoing investigations of avian keratin disorder in Black‐capped Chickadees and other wild passerine species. © 2011 Wiley Periodicals, Inc.
Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins
Authors: Ye Long , Xu Aizhang , Cheng Chao , Zhang Li , Huo Chenxi , Huang Feiyun , Xu Hong , Li Rongxiu 
Published: October 2011

AbstractAffinity chromatography has played an increasingly important role both in the pharmaceutical industry and academic research. In the present study, we report our preliminary investigation on the relationship between the affinity ligand structure and its adsorption to multi‐protein samples. The structure of the ligands, including the size of the ring (cyclic group) and the length of the chain (linear group), has a great impact on the adsorption of ligands to proteins. Meanwhile, the functional groups that the ligands carry are also closely related to the adsorption of ligands to proteins. This research provides good guidance for the design and synthesis of affinity materials in affinity chromatography. It is also useful to other protein–ligand interaction‐related research.
Consensus treatment recommendations for late‐onset Pompe disease
Authors: Cupler Edward J. , Berger Kenneth I. , Leshner Robert T. , Wolfe Gil I. , Han Jay J. , Barohn Richard J. , Kissel John T. ,   of the AANEM CONSENSUS COMMITTEE ON LATE‐ONSET POMPE DISEASE
Published: October 2011

AbstractIntroduction: Pompe disease is a rare, autosomal recessive disorder caused by deficiency of the glycogen‐degrading lysosomal enzyme acid alpha‐glucosidase. Late‐onset Pompe disease is a multisystem condition, with a heterogeneous clinical presentation that mimics other neuromuscular disorders. Methods: Objective is to propose consensus‐based treatment and management recommendations for late‐onset Pompe disease. Methods: A systematic review of the literature by a panel of specialists with expertise in Pompe disease was undertaken. Conclusions: A multidisciplinary team should be involved to properly treat the pulmonary, neuromuscular, orthopedic, and gastrointestinal elements of late‐onset Pompe disease. Presymptomatic patients with subtle objective signs of Pompe disease (and patients symptomatic at diagnosis) should begin treatment with enzyme replacement therapy (ERT) immediately; presymptomatic patients without symptoms or signs should be observed without use of ERT. After 1 year of ERT, patients' condition should be reevaluated to determine whether ERT should be continued. Muscle Nerve, 2012
Effect of locomotor training on muscle performance in the context of nerve–muscle communication dysfunction
Authors: Hadj‐Saïd Wahiba , Bangratz Marie , Vignaud Alban , Chatonnet Arnaud , Butler‐Browne Gillian , Nicole Sophie , Agbulut Onnick , Ferry Arnaud 
Published: October 2011

AbstractIntroduction: The effects of locomotor training (LT) on skeletal muscle after peripheral nerve injury and acetylcholinesterase deficiency are not well documented. Methods: We determined the effects of LT on mouse soleus muscle performance after sciatic nerve transection with excision (full and permanent denervation), nerve transection (partial functional reinnervation), nerve crush (full denervation with full functional reinnervation), and acetylcholinesterase deficiency (alteration in neuromuscular junction functioning). Results: We found no significant effect of LT on the recovery of soleus muscle weight, maximal force in response to muscle stimulation, and fatigue resistance after nerve transection with or without excision. However, LT significantly increased soleus muscle fatigue resistance after nerve crush and acetylcholinesterase deficiency. Moreover, hindlimb immobilization significantly aggravated the deficit in soleus muscle maximal force production and atrophy after nerve crush. Conclusions: LT is beneficial, and reduced muscle use is detrimental for intrinsic muscle performance in the context of disturbed nerve–muscle communication. Muscle Nerve, 2012
Validation and application of a death proxy in adult cancer patients
Authors: Mealing Nicole M. , Dobbins Timothy A. , Pearson Sallie‐Anne 
Published: October 2011

ABSTRACTPurposeFact of death is not always available on data sets used for pharmacoepidemiological research. Proxies may be an appropriate substitute in the absence of death data. The purposes of this study were to validate a proxy for death in adult cancer patients and to assess its performance when estimating survival in two cohorts of cancer patients.MethodsWe evaluated 30‐, 60‐, 90‐ and 180‐day proxies overall and by cancer type using data from 12 394 Australian veterans with lung, colorectal, breast or prostate cancer. The proxy indicated death if the difference between the last dispensing record and the end of the observational period exceeded the proxy cutoff. We then compared actual survival to 90‐day proxy estimates in a subset of 4090 veterans with ‘full entitlements’ for pharmaceutical items and in 3704 Australian women receiving trastuzumab for HER2+ metastatic breast cancer.ResultsThe 90‐day proxy was optimal with an overall sensitivity of 99.3% (95%CI: 98.4–99.7) and a specificity of 97.6% (95%CI: 91.8–99.4). These measures remained high when evaluated by cancer type and spread of disease. The application of the proxy using the most conservative date of death estimate (date of last dispensing) generally underestimated survival, with estimates up to 3 months shorter than survival based on fact of death.ConclusionsA 90‐day death proxy is a robust substitute to identify death in a chronic population when fact of death is not available. The proxy is likely to be valid across a range of chronic diseases as it relies on the presence of ‘regular’ dispensing records for individual patients. Copyright © 2011 John Wiley & Sons, Ltd.
Process safety management—You can't get it right without a good safety culture
Authors: Hendershot Dennis C. 
Published: October 2011

AbstractAn effective process safety culture is essential to an effective process safety management (PSM) program. A good safety culture is the difference between doing aPSM activity, and doing it well. Without a good culture, an organization can check off the boxes indicating that various PSM activities have been done, but the product of those activities may have little valuable content, and the PSM program may not be effective. © 2011 American Institute of Chemical Engineers Process Saf Prog, 2012
Nanosheet‐based BiVO4 hierarchical microspheres and their photocatalytic activity under visible light
Authors: Li Jun‐Qi , Wang De‐Fang , Liu Hui , Du Juan , Zhu Zhen‐Feng 
Published: October 2011

AbstractHierarchical BiVO4 microspheres assembled by nanosheets were synthesized by hydrothermal process under microwave irradiation. The morphology and compositional characteristics of the BiVO4 architectures were investigated by SEM, TEM, and XRD. The possible formation mechanism for the architectures was discussed. UV–vis diffuse reflectance spectra indicated the BiVO4 hierarchical microspheres had absorption in both UV and vis light areas. The specific surface area and porosity of the BiVO4 architectures were investigated by using nitrogen adsorption and desorption isotherms. Because of the narrow bandgap and the novel micro‐/nanostructure, the BiVO4 architectures show a more excellent photocatalytic activity under visible light irradiation than the BiVO4 solid microspheres and P25. Several possible reasons for the higher photocatalytic activity have been taken into consideration, namely, high specific surface area, hierarchical mesoporous structure, and quantum size effect. In addition, the photocatalyst is stable during the reaction and can be used repeatedly.
Junge Menschen mit Behinderung auf dem Weg in den Beruf: Herausforderungen in der Datenanalyse
Authors: Niehaus Mathilde , Klinkhammer Dennis , Friedrich-Gärtner Lene 
Published: October 2011

Einleitung
Der Weg von der Schule in den Ausbildungs- und Arbeitsmarkt erscheint auf den ersten Blick nachvollziehbar. Doch gerade bei jungen Menschen mit Behinderungen können sich Schwierigkeiten bei diesem Übergang einstellen. Versucht man diese eingehender zu betrachten, stößt man sehr schnell auf analytische Grenzen. Die Distanz zwischen dem abgebenden Schulsystem und den aufnehmenden Systemen des Ausbildungs- und Arbeitsmarktes spiegelt sich dabei vor allen Dingen in der statistischen Datenlage wieder.
Rehabilitation - was ist und was nötig ist
Authors: Schott Thomas 
Published: October 2011

Einleitung
Maßnahmen der medizinischen Rehabilitation sowie Leistungen zur Teilhabe am Arbeitsleben gehören zu den wichtigsten Errungenschaften der sozialen Sicherheit in Deutschland. Ziel jeder Reha-Maßnahme ist - neben der Wiedergewinnung und Aufrechterhaltung der körperlichen Integrität - die Beibehaltung oder Wiedererlangung der sozialen Integration bzw. der sozialen Teilhabe.
On the entropy of actions of nilpotent Lie groups and their lattice subgroups
Authors: DOOLEY A. H. , GOLODETS V. YA. 
Published: October 2011

AbstractWe consider a natural class $\mathcal {ULG}$ of connected, simply connected nilpotent Lie groups which contains ℝn, the group $\mathcal {UT}_n(\mathbb {R})$ of all triangular unipotent matrices over ℝ and many of its subgroups, and is closed under direct products. If $G \in \mathcal {ULG}$, then $\Gamma _1 = G\cap \mathcal {UT}_n(\mathbb {Z})$ is a lattice subgroup of G. We prove that if $G \in \mathcal {ULG}$ and Γ is a lattice subgroup of G, then a free ergodic measure-preserving action T of G on a probability space (X,ℬ,μ) has completely positive entropy (CPE) if and only if the restriction TΓ of T to Γ has CPE. We can deduce from this the following version of a well-known conjecture in this case: the action T has CPE if and only if T is uniformly mixing. Moreover, such T has a Lebesgue spectrum with infinite multiplicity. We further consider an ergodic free action T with positive entropy and suppose TΓ is ergodic for any lattice subgroup Γ of G. This holds, in particular, if the spectrum of T does not contain a discrete component. Then we show the Pinsker algebra Π(T) of T exists and coincides with the Pinsker algebras Π(TΓ) of TΓ for any lattice subgroup Γ of G. In this case, T always has Lebesgue spectrum with infinite multiplicity on the space ℒ20(X,μ)⊖ℒ20(Π(T)) , where ℒ20(Π(T)) contains all Π(T) -measurable functions from ℒ20(X,μ) . To prove these results, we use the following formula: h(T)=∣G(Γ)∣−1hK (TΓ) , where h(T) is the Ornstein–Weiss entropy of T, hK (TΓ) is a Kolmogorov–Sinai entropy of TΓ, and the number ∣G(TΓ)∣ is the Haar measure of the compact subset G(Γ) of G. In particular, h(T)=hK (TΓ1) , and hK (TΓ1)=∣G(Γ)∣−1hK (TΓ) . The last relation is an analogue of the Abramov formula for flows.