bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aesthetic Surgery Tourism: An Opportunity or a Danger?
Authors: Budini Valentina , Zanettin Chiara , Brambullo Tito , Bassetto Franco , Vindigni Vincenzo 
Published: June 2024

Abstract
Background
Medical and surgical tourism is a rapidly growing phenomenon in post-pandemic Europe. The exodus of patients abroad to perform surgery, especially cosmetic treatments, is spreading recently in industrialized countries. In the social media era, the ease of access to advertising about surgical procedures and their costs favors traveling. However, the information given is not always punctual, and there is often a lack of patient awareness about the risks related to the procedures.

Methods
The objective of the manuscript is to investigate, through clinical examples, the path that a patient operated on in a non-European country must face once he returns home. From the availability and translation of clinical documentation to the problems encountered in revision surgeries.

Results
Thirteen cases of surgical tourism, patients who presented to our department with surgical complications, are investigated. Adverse events occurring during medical treatment abroad raised medico-legal and appropriateness issues, as well as concerns regarding the follow-up of patients.

Conclusions
The current literature confirmed the high complication rate: It affects individual patients and the native country's healthcare systems. Therefore, patients must learn more about the dangers of traveling abroad for surgery. Education initiatives in the patient's home country might help achieve this.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Coral reef potential connectivity in the southwest Indian Ocean
Authors: Vogt-Vincent Noam S. , Burt April J. , van der Ven Rosa M. , Johnson Helen L. 
Published: June 2024

AbstractThe tropical southwest Indian Ocean is a coral biodiversity hotspot, with remote reefs physically connected by larval dispersal through eddies and a complex set of equatorial and boundary currents. Based on multidecadal, 2 km resolution hydrodynamic and larval dispersal models that incorporate temporal variability in dispersal, we find that powerful zonal currents, current bifurcations, and geographic isolation act as leaky dispersal barriers, partitioning the southwest Indian Ocean into clusters of reefs that tend to consistently retain larvae, and therefore gene flow, over many generations. Whilst exceptionally remote, the Chagos Archipelago can broadcast (and receive) considerable numbers of larvae to (and from) reefs across the wider southwest Indian Ocean, most significantly exchanging larvae with the Inner Islands of Seychelles, but also the Mozambique Channel region. Considering multi-generational dispersal indicates that most coral populations in the southwest Indian Ocean are physically connected within a few hundred steps of dispersal. These results suggest that regional biogeography and population structure can be largely attributed to geologically recent patterns of larval dispersal, although some notable discrepancies indicate that palaeogeography and environmental suitability also play an important role. The model output and connectivity matrices are available in full and will provide useful physical context to regional biogeography and connectivity studies, as well as supporting marine spatial planning efforts.
Preservation of orbit in tumor invasion through the periorbita in sinonasal malignancy
Authors: Novak Stepan , Balatkova Zuzana , Fikova Alzbeta , Grega Marek , Kalfert David , Plzak Jan 
Published: June 2024

Abstract
Objective
One of the possible risks of sinonasal malignancy is its possible spread in the orbit. However, there is no clear consensus among the different departments as to whether it is necessary to exenterate the orbit in limited tumorous infiltration of periorbital fat. The purpose of the study was to demonstrate that periorbital infiltration and periorbital fat invasion without involvement of deeper orbital tissues are not the indication of orbital exenteration.

Materials and methods
Retrospective analysis was performed over a 17-year period of patients undergoing surgical treatment for sinonasal malignancy with histologically verified periorbital infiltration or deeper invasion into the orbit. A total of 32 patients were included in the study. For each group, the following data were analysed: sex, age, preoperative imaging studies, histological findings, site of origin, stage, surgical reconstruction, oncological treatment, survival, cause of death, number of recurrences in the orbit and functional status of preserved eyes.

Results
Based on our criteria for orbital exenteration, orbital preservation was feasible in 18 patients. Orbital exenteration was performed in 14 patients with deeper tumor infiltration. There was a statistically insignificant difference in survival between the two groups. The 5-year overall survival (OS) was 44% for the orbital preservation group (only 2 patients died from local tumor recurrence) and 34% for the orbital exenteration group. The groups did not differ in other observed factors other than the extent of orbital infiltration. In 11 (61.1%) patients, vision was without significant change after radiation therapy. In 2 (11.1%) patients, visual function was impaired due to diplopia. 5 (27.8%) patients had severely impaired vision due to optic nerve atrophy after radiation therapy.

Conclusions
Our results show a relatively high survival rate in the group of patients with orbital preservation with a high chance of vision preservation, which justifies our approach to orbital preservation even in some tumors with periorbital infiltration.
Buprenorphine deaths confirmed by toxicology reveal a low proportion of opioid agonist treatment before death in Finland
Authors: Mariottini Claudia , Häkkinen Margareeta , Kriikku Pirkko , Ojanperä Ilkka 
Published: June 2024

AbstractWe studied opioid agonist treatment (OAT) status before buprenorphine-related death in Finland, where buprenorphine is the principal OAT medicine and also the most misused opioid, through a retrospective population-based study using medico-legal cause-of-death investigation and OAT patient records. The study included all death cases (N = 570) between 2018 and 2020 with a buprenorphine or norbuprenorphine finding in post-mortem toxicology and with known drug misuse history or concomitant findings of illicit drugs. Of the deceased, 10% had received OAT in the year before death. Less than 1% of individuals < 25 years had received OAT, whereas the proportion in individuals ≥ 25 years was 13% (p < 0.001). There were significantly more females and more fatal poisonings (p < 0.001) among those < 25 years than among those ≥ 25 years. OAT medication at the time of death was sublingual buprenorphine-naloxone in 74% and subcutaneous buprenorphine in 23%. Except for significantly fewer benzodiazepine findings among those receiving OAT, minimal differences were found in terms of age, gender, cause and manner of death, or concomitant substance use between the deceased in and outside of OAT. Concomitant misuse of benzodiazepines, psychostimulants, alcohol, and gabapentinoids was frequent both in and outside of OAT and likely contributed to the death. These results suggest that access to OAT especially for young people and treatment of multiple addictions should be improved. Comprehensive information from medico-legal cause-of-death investigation as a starting point, combined with subsequent ante-mortem patient records, proved to be a successful approach to shed light on the Finnish scene of buprenorphine mortality.
Attention-guided LiDAR segmentation and odometry using image-to-point cloud saliency transfer
Authors: Ding Guanqun , İmamoğlu Nevrez , Caglayan Ali , Murakawa Masahiro , Nakamura Ryosuke 
Published: June 2024

AbstractLiDAR odometry estimation and 3D semantic segmentation are crucial for autonomous driving, which has achieved remarkable advances recently. However, these tasks are challenging due to the imbalance of points in different semantic categories for 3D semantic segmentation and the influence of dynamic objects for LiDAR odometry estimation, which increases the importance of using representative/salient landmarks as reference points for robust feature learning. To address these challenges, we propose a saliency-guided approach that leverages attention information to improve the performance of LiDAR odometry estimation and semantic segmentation models. Unlike in the image domain, only a few studies have addressed point cloud saliency information due to the lack of annotated training data. To alleviate this, we first present a universal framework to transfer saliency distribution knowledge from color images to point clouds, and use this to construct a pseudo-saliency dataset (i.e. FordSaliency) for point clouds. Then, we adopt point cloud based backbones to learn saliency distribution from pseudo-saliency labels, which is followed by our proposed SalLiDAR module. SalLiDAR is a saliency-guided 3D semantic segmentation model that integrates saliency information to improve segmentation performance. Finally, we introduce SalLONet, a self-supervised saliency-guided LiDAR odometry network that uses the semantic and saliency predictions of SalLiDAR to achieve better odometry estimation. Our extensive experiments on benchmark datasets demonstrate that the proposed SalLiDAR and SalLONet models achieve state-of-the-art performance against existing methods, highlighting the effectiveness of image-to-LiDAR saliency knowledge transfer. Source code will be available at https://github.com/nevrez/SalLONet
Distinctive sleep complaints and polysomnographic findings in antibody subgroups of autoimmune limbic encephalitis
Authors: Küçükali Cem İsmail , Yılmaz Vuslat , Karadeniz Derya , Akyıldız Utku Oğan , İlhan Algın Demet , Sarıtaş Ayşegül Şeyma , Kısabay Ak Ayşın , Bican Demir Aylin , Yılmaz Hikmet , Domaç Füsun Mayda , Elmalı Ayşe Deniz , Hoş Ülkü Dübüş , Gözübatık-Çelik R. Gökçen , Kabeloğlu Vasfiye , Bilgin Bengisu , Tuncel Berktaş Deniz , Türk Bengi Gül , Delil Şakir , Dilber Cengiz , Terzioğlu Öztürk Sedef , Yeni S. Naz , Özkara Çiğdem , Aksu Murat , Tüzün Erdem , Benbir Şenel Gülçin 
Published: June 2024

Abstract
Introduction
Sleep disturbances are being increasingly recognized in association with autoimmune encephalitis (AIE). We investigated the prevalence of sleep-related symptoms and polysomnographic features of patients with AIE and the long-term outcomes in these patients in a multi-center, prospective study from Turkey.

Methods
We prospectively evaluated patients with definite AIE in a common database including demographics, AIE-related and sleep-related symptomatology. Maximum and latest modified Rankin scores (mRS) and Liverpool Outcome Score (LOS) were noted.

Results
Of 142 patients, 87 patients (61.3%) fulfilled the criteria for definite AIE (mean age, 46.8+18.8 years; 51.7% women; mean disease duration, 21.0+38.4 months). 78.9% of patients had at least one or more new onset or worsened sleep-related symptomatology: insomnia (55.3%), excessive daytime sleepiness (EDS, 28.0%), sleep apnea (18.7%), REM sleep behavior disorder (RBD, 17.3%), restless legs syndrome (10.7%) and oneiric stupor (9.3%). Sleep efficiency, N3 and REM sleep were decreased and N1 sleep was increased in patients with Ab[+] AIE. LOS points were highest in those with insomnia and sleep apnea, and lowest in those with EDS, RBD and oneiric stupor. RBD and sleep apnea were more common in anti-LG1 Ab[+] group than anti-NMDAR Ab[+] group. Index of periodic leg movements was highest in anti-LG1 Ab[+] group. Patients with EDS and oneiric stupor had more common memory problems. Maximum and latest mRS scores were positively correlated with EDS and oneiric stupor. EDS, RBD and oneiric stupor were negatively correlated with LOS points.

Conclusion
Our study emphasizes the presence and importance of early diagnosis of sleep disturbances in AIE in regard to their deteriorative influences on disease prognosis.
Unlocking the potential: laser surface modifications for titanium dental implants
Authors: Kolarovszki Bela , Ficsor Szabolcs , Frank Dorottya , Katona Krisztian , Soos Balazs , Turzo Kinga 
Published: June 2024

Abstract
The review critically evaluates the current state of studies investigating laser irradiation for modifying titanium surfaces to enhance the biointegration of dental implants. Laser modification is a rapidly evolving physicochemical surface modification process with the potential to revolutionize dental implant technology. A thorough search of electronic databases, including PubMed, Science Direct, MEDLINE, and Web of Knowledge, was conducted to identify relevant articles. The review focuses on the surface features of laser-modified implants, encompassing in vitro cell culture experiments, rare animal experiments, and limited clinical trials. Of the 26 selected sources, 21 describe surface features, while only two involve in vivo human experiments. The review highlights the lack of long-term clinical experience and calls for further research to mature these technologies. Despite the absence of a consensus on optimal laser types and settings, the overall results are promising, with few negative outcomes. As research in laser irradiation of titanium surfaces progresses, significant advancements in dental implant technology and improved patient well-being are anticipated.
Association between hospital palliative care team intervention volume and patient outcomes
Authors: Abe Hiroaki , Sumitani Masahiko , Matsui Hiroki , Inoue Reo , Fushimi Kiyohide , Uchida Kanji , Yasunaga Hideo 
Published: June 2024

Abstract
Background
The benefits of palliative care in patients with advanced cancer are well established. However, the effect of the skills of the palliative care team (PCT) on patient outcomes remains unclear. Our aim was to evaluate the association between hospital PCT intervention volume and patient outcomes in patients with cancer.

Methods
A retrospective cohort study was conducted using a nationwide inpatient database in Japan. Patients with cancer receiving chemotherapy and PCT intervention from 2015 to 2020 were included. The outcomes were incidence of hyperactive delirium within 30 days of admission, mortality within 30 days of admission, and decline in activities of daily living (ADL) at discharge. The exposure of interest was hospital PCT intervention volume (annual number of new PCT interventions in a hospital), which was categorized into low-, intermediate-, and high-volume groups according to tertiles. Multivariate logistic regression and restricted cubic-spline regression were conducted.

Results
Of 29,076 patients, 1495 (5.1%), 562 (1.9%), and 3026 (10.4%) developed delirium, mortality, and decline in ADL, respectively. Compared with the low hospital PCT intervention volume group (1–103 cases/year, n = 9712), the intermediate (104–195, n = 9664) and high (196–679, n = 9700) volume groups showed significant association with lower odds ratios of 30-day delirium (odds ratio, 0.79 [95% confidence interval, 0.69–0.91] and 0.80 [0.69–0.93], respectively), 30-day mortality (0.73 [0.60–0.90] and 0.59 [0.46–0.75], respectively), and decline in ADL (0.77 [0.70–0.84] and 0.52 [0.47–0.58], respectively).

Conclusion
Hospital PCT intervention volume is inversely associated with the odds ratios of delirium, mortality, and decline in ADL among hospitalized patients with cancer.
Assessment of apical extrusion in regenerative endodontics: a comparative study of different irrigation methods using three-dimensional immature tooth models
Authors: Abat Vahide Hazal , Bayrak Gökçen Deniz , Gündoğar Mustafa 
Published: June 2024

AbstractTo investigate the apical extrusion of sodium hypochlorite in immature permanent teeth caused by conventional syringe irrigation (CSI), EDDY, XP-endo Finisher file (XP-F), and a new laser irrigation activation system [shock-wave-enhanced-emission-photo-acoustic-streaming (SWEEPS)]. Three-dimensionally printed forty-nine teeth with immature central incisor morphology were randomly assigned to seven experimental groups, based on the irrigation activation methods and insertion depths (1 mm and 2 mm short of the working length) as follows: CSI-1, CSI-2, EDDY-1, EDDY-2, XP-1, XP-2, and SWEEPS. Prior to the irrigation activation process, samples were placed in metacresol mixed agar gel in Eppendorf tubes. To evaluate NaOCI extrusion into the gel, each sample was digitally photographed, and the area of apical extrusion was analyzed using ImageJ software. To examine potential significant differences between the continuous variables, the Mann–Whitney U test and Kruskal–Wallis H test, were applied (P = .05). The SWEEPS resulted in a greater amount of apical extrusion compared to the CSI method, regardless of the insertion depth (P < 0.001). The SWEEPS resulted in greater apical extrusion scores compared to EDDY-2 (P < 0.001). The EDDY-1 resulted in greater amount of apical extrusion scores compared to EDDY-2 (P < 0.001). This study, the first to show the effect of the novel SWEEPS technology on NaOCI extrusion, found that irrigation activation can cause different levels of apical extrusion depending on the method and distance from the working length. It is crucial to consider the potential occurrence of apical extrusion when applying activation methods to immature teeth.
Stochastic modeling of stationary scalar Gaussian processes in continuous time from autocorrelation data
Authors: Hanke Martin 
Published: June 2024

AbstractWe consider the problem of constructing a vector-valued linear Markov process in continuous time, such that its first coordinate is in good agreement with given samples of the scalar autocorrelation function of an otherwise unknown stationary Gaussian process. This problem has intimate connections to the computation of a passive reduced model of a deterministic time-invariant linear system from given output data in the time domain. We construct the stochastic model in two steps. First, we employ the AAA algorithm to determine a rational function which interpolates the z-transform of the discrete data on the unit circle and use this function to assign the poles of the transfer function of the reduced model. Second, we choose the associated residues as the minimizers of a linear inequality constrained least squares problem which ensures the positivity of the transfer function’s real part for large frequencies. We apply this method to compute extended Markov models for stochastic processes obtained from generalized Langevin dynamics in statistical physics. Numerical examples demonstrate that the algorithm succeeds in determining passive reduced models and that the associated Markov processes provide an excellent match of the given data.
Which birds have the most to lose? an analysis of bird species’ feeding habitat in changing Australian landscapes
Authors: Campbell Carly E. , Jones Darryl N. , Awasthy Monica , Castley J. Guy , Chauvenet Alienor L.M. 
Published: June 2024

AbstractAustralia has lost vast areas of its natural vegetation through agriculture and urbanization, resulting in the area of suitable habitat for many Australian bird species being greatly diminished. Given the geographical and ecological biases in anthropogenic land use, the impact of habitat loss now and into the future may be disproportionately high for some species, threatening their long-term persistence. Such changes are occurring rapidly, and habitat loss needs to be monitored dynamically to prevent extinction. To monitor changes in available unmodified species habitat, we use species’ area of feeding habitat (AFH), which represents the area of habitat within a species’ range with vegetation matching their feeding requirements. We analysed the past, current and future threats of habitat modification for 467 Australian bird species by calculating AFH across three time periods: pre-colonization, current (2020), and a projected future scenario (2100). These values were used to identify species subject to substantial habitat loss due to urbanization and agriculture and delineate predictors of such losses. Most species had experienced habitat loss since colonization (n = 442, 95%), and species that had already experienced considerable habitat loss were more likely to lose habitat into the future. Species with particular habitat associations (e.g., Mallee), were also more prone to greater proportions of habitat lost. The results highlight the utility of AFH and emphasize the importance of protecting what habitat remains for the species with highly depleted geographic ranges, noting that those that have experienced the most loss of unmodified habitat are the most likely to lose more unmodified habitat under future conditions.
Identifying research priorities for improving information and support for patients undergoing breast cancer surgery: a UK patient-centred priority setting project
Authors: Johnston Emma , Cowan Katherine , MacKenzie Mairead , Patton Sonia , Turner Lesley , Fairbrother Patricia , McIntosh Stuart A. , Potter Shelley 
Published: June 2024

Abstract
Purpose
To use robust consensus methods with individuals with lived breast cancer experience to agree the top 10 research priorities to improve information and support for patients undergoing breast cancer surgery in the UK.

Methods
Research uncertainties related to information and support for breast cancer surgery submitted by patients and carers were analysed thematically to generate summary questions for inclusion in an online Delphi survey. Individuals with lived breast cancer experience completed two Delphi rounds including feedback in which they selected their top 10 research priorities from the list provided. The most highly ranked priorities from the survey were discussed at an in-person prioritisation workshop at which the final top 10 was agreed.

Results
The 543 uncertainties submitted by 156 patients/carers were categorised into 63 summary questions for inclusion in the Delphi survey. Of the 237 individuals completing Round 1, 190 (80.2%) participated in Round 2. The top 25 survey questions were carried forward for discussion at the in-person prioritisation workshop at which 17 participants from across the UK agreed the final top 10 research priorities. Key themes included ensuring patients were fully informed about all treatment options and given balanced, tailored information to support informed decision-making and empower their recovery. Equity of access to treatments including contralateral mastectomy for symmetry was also considered a research priority.

Conclusion
This process has identified the top 10 research priorities to improve information and support for patients undergoing breast cancer surgery. Work is now needed to develop studies to address these important questions.