bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sorafenib for Patients with Advanced Angiosarcoma: A Phase II Trial from the French Sarcoma Group (GSF/GETO)
Authors: Ray-Coquard Isabelle , Italiano Antoine , Bompas Emmanuelle , Le Cesne Axel , Robin Yves-Marie , Chevreau Christine , Bay Jacques-Olivier , Bousquet Guilhem , Piperno-Neumann Sophie , Isambert Nicolas , Lemaitre Laurent , Fournier Charles , Gauthier Eric , Collard Olivier , Cupissol Didier , Clisant Stéphanie , Blay Jean-Yves , Penel Nicolas ,   on behalf of the French Sarcoma Group (GSF/GETO)
Published: January 2012

Abstract

Background.
Angiosarcomas account for &lt;2% of all soft tissue sarcomas. This subtype is one of the most aggressive forms of soft tissue sarcoma. The prognosis for angiosarcoma patients in the advanced phase remains poor with current cytotoxic agents (progression-free survival [PFS] time of ∼4 months and overall survival [OS] time of ∼8 months). We investigated the antitumor activity of sorafenib in patients with metastatic or advanced angiosarcomas in a phase II trial.

Methods.
We conducted a stratified phase II trial. The primary endpoint was the progression-free rate (PFR) at 9 months according to the Response Evaluation Criteria in Solid Tumors. A two-stage design (optimal Simon design) was used. Patients received sorafenib (400 mg twice daily) for 9 months until unacceptable toxicity or tumor progression. Central pathological and radiological reviews were performed. Data on stratum A (superficial angiosarcoma) and stratum B (visceral angiosarcoma) are currently available. This trial is registered with ClinicalTrials.gov (identifier, NCT00874874).

Findings.
Strata A and B recruited 26 and 15 patients, respectively. The median age was 63 years (range, 31–82 years), with 17 male and 24 female patients. Fourteen cases arose in irradiated fields. Thirty patients (73.0%) had been pretreated with conventional chemotherapy. No unexpected toxicity occurred. The PFR at 9 months was 3.8% in stratum A and 0.0% in stratum B. The median PFS times were 1.8 months and 3.8 months, respectively, whereas the median OS times were 12.0 months and 9.0 months, respectively. No responses were observed in chemotherapy-naïve patients, whereas a 40% tumor control rate and 23% response rate were observed in the pretreated population. In this cohort, no activating mutation of the KDR gene (exons 15, 16, 24) was detected.

Interpretation.
Sorafenib showed limited antitumor activity in pretreated patients only, for both visceral and superficial angiosarcoma, but tumor control was of short duration.
The crystal structure of Ho4Ni11In20
Authors: Tyvanchuk Yuriy , Svitlyk Volodymyr , Kalychak Yaroslav 
Published: January 2012

Abstract
The polycrystalline Ho4Ni11In20 was obtained by arc-melting of the elements. The subsequent high temperature procedure was used for single crystal growth. Crystal structure of the compound was investigated by X-ray single crystal method: U4Ni11Ga20 type, C 2/m, a = 22.4528(17), b = 4.2947(3), c = 16.5587(13) Å, β = 124.591(5)°, R1 = 0.0276, wR2 = 0.0493 for 1989 independent reflections with [I&gt;2σ(I)]. The structure is composed of three-dimensional network from Ni and In atoms in which Ho atoms fill distorted pentagonal channels.
Thermodynamic dissociation constants of risedronate using spectrophotometric and potentiometric pH-titration
Authors: Meloun Milan , Ferenčíková Zuzana , Málková Hana , Pekárek Tomáš 
Published: January 2012

Abstract
Risedronate inhibits bone resorption in diseases like osteoporosis, Paget’s disease, tumor bone diseases or the malfunction of phosphocalcium metabolism. The acid-base properties of risedronate in an aqueous solution have been studied in a pH range from 2 to 12 and can be described in terms of four dissociation steps: pK a,2, pK a,4, pK a,5 (related to the dissociation of POH groups) and pK a,3 related to the dissociation of protonated amino group NH3+. The mixed dissociation constants were determined at different ionic strengths I = 0.02 to 0.20 mol dm−3 KCl and of 25°C and 37°C using pH-spectrophotometric and pH-potentiometric titration methods. Determination of group parameters L 0, H T might lead to false estimates of common parameters p K a;therefore, the computational strategy employed is important. A comparison between the two programs ESAB and HYPERQUAD demonstrated that the ESAB program provides a better fit of potentiometric titration curve. The thermodynamic dissociation constants pK aT were estimated by a nonlinear regression of (pK a, I) data and a Debye-Hückel equation at 25°C and 37°C, pK a,2T = 2.37(1) and 2.44(1), pK a,3T = 6.29(3) and 6.26(1), pK a,4T = 7.48(1) and 7.46(2) and pK a,5T = 9.31(7) and 8.70(3) at 25°C and 37°C using pH-spectroscopic data and pK a,2T = 2.48(3) and 2.43(1), pK a,3T= 6.12(2) and 6.10(2), pK a,4T = 7.25(2) and 7.23(1) and pK a,5T = 12.04(5) and 11.81(2) at 25°C and 37°C. The ascertained estimates of three dissociation constants pK a,3, pK a,4, pK a,5 are in agreement with the predicted values obtained using PALLAS
New 1H-1-alkyl-6-methyl-3-phenyl-7-phenylazo-pyrazolo[5,1-c][1,2,4]triazoles through regioselective alkylation of 1H-6-methyl-3-phenyl-7-phenylazopyrazolo[5,1-c][1,2,4]triazoles
Authors: Bercean Vasile-Nicolae , Badea Valentin , Deleanu Călin , Nicolescu Alina 
Published: January 2012

Abstract
1H-1-Alkyl-6-methyl-3-phenyl-7-phenylazopyrazolo[5,1-c][1,2,4]triazoles (2aa-ad) were obtained by regioselective alkylation of 1H-6-methyl-3-phenyl-7-phenylazopyrazolo[5,1-c][1,2,4]triazoles (2a). 1H-1-Alkyl-6-methyl-3-phenyl-7-phenylazopyrazolo[5,1-c][1,2,4]triazoles 2aa and 2ab were also prepared by coupling phenyldiazonium chloride with 1H-1-alkyl-6-methyl-3-phenyl-pyrazolo[5,1-c][1,2,4]triazoles 1aa and 1ab. The new compounds were characterized by IR, UV-VIS, 1H-NMR, 13C-NMR, and 15N-NMR spectroscopy and their structures and actual tautomeric forms were established unequivocally.
Mung bean response during immobilization of exchangeable aluminum in acidic soil
Authors: Skwira Monika , Jakóbik-Kolon Agata , Ciba Jerzy 
Published: January 2012

Abstract
A soil incubation and shot-term plant growth experiment was conducted to study the effect of ferruginous mineral application on exchangeable Al immobilization. The mineral containing mainly siderite was mixed at various rates with A-horizon soil and incubated at 80% humidity for 45 days. Following the incubation, a short-term plant growth test was carried out using mung beans. The ferruginous mineral application into tested soil resulted in a reduction of the exchangeable aluminum concentration and soil acidity. An increase in root growth and stalk length, as well as a general improvement of plant condition was observed in the case of ferruginous mineral application. This observation was confirmed by chemical analysis of roots and stalks. The greatest amount of essential elements: calcium and magnesium and the lowest amount of aluminum were determined in green part of mung beans sown in the soil with addition of 2% ferruginous mineral.
A review on the synthesis of TiO2 nanoparticles by solution route
Authors: Gupta Shipra , Tripathi Manoj 
Published: January 2012

Abstract
TiO2 can be prepared in the form of powder, crystals, or thin films. Liquid-phase processing is one of the most convenient and utilized methods of synthesis. It has the advantage of allowing control over the stoichiometry, production of homogeneous materials, formation of complex shapes, and preparation of composite materials. However, there may be some disadvantages such as expensive precursors, long processing times, and the presence of carbon as an impurity. In comparison, the physical production techniques, although environment friendly, are limited by the size of the produced samples which is not sufficient for a large-scale production. The most commonly used solution routes in the synthesis of TiO2 are reviewed.
Synthesis of dibromo ketones by the reaction of the environmentally benign H2O2-HBr system with oximes
Authors: Terent’ev Alexander , Krylov Igor , Vil’ Vera , Pastukhova Zhanna , Fastov Sergey , Nikishin Gennady 
Published: January 2012

Abstract
It was found that oximes undergo deoximation in the presence of the H2O2aq-HBraq system to form ketones and bromo ketones. This reaction provided the basis for the synthesis of dibromo ketones in yields varying from 40% to 94%. This method is environmentally friendly, sustainable, and easy to perform. The results of this investigation extend the potential of the use of oximes for the protection of carbonyl group, thus offering the ability to perform not only conventional deoximation but also the subsequent bromination of ketones. The reaction is easily scaled up and dibromo ketones can be prepared in gram amounts.
Mathematical approach to investigation of synthesis processes at high temperatures
Authors: Mackevičius Mažvydas , Ivanauskas Feliksas , Kareiva Aivaras 
Published: January 2012

Abstract
In our work, we present a method for estimation of the diffusion and reaction rates of synthesis at high temperatures using limited information from laboratory experiments, such as synthesis time and dimensions of reactants. Synthesis by sol-gel and solid-state reactions is considered. The inverse modeling problem is solved for one- and two-dimensional models. Explicit formulas for the diffusion coefficient and reaction rate as functions of temperature are obtained. The activation energies are calculated, and the lower bounds of diffusion and reaction rates are estimated, thus obtaining conditions for occurrence of synthesis.
Theoretical investigation of the Anti-Parkinson drug rasagiline and its salts: conformations and infrared spectra
Authors: Başköse U. , Bayarı Sevgi , Sağlam Semran , Özışık Hacı 
Published: January 2012

Abstract
The conformational analysis of rasagiline [N-propargyl-1(R)-aminoindan] was performed by the density functional theory (DFT) B3LYP method using the 6–31++G (d,p) basis set. A single point energy calculations based on the B3LYP optimized geometries were also performed at MP2/6-31++G (d, p) level. The vibrational frequencies of the most stable conformer of rasagiline was calculated at the B3LYP level and vibrational assignments were made for normal modes on the basis of scaled quantum mechanical force field (SQM) method. The influence of mesylate and ethanedisulfonate salts on the geometry of rasagiline free base and its normal modes are also discussed.
Synthesis of novel 3-deoxy-3-C-triazolylmethyl-allose derivatives and evaluation of their biological activity
Authors: Rjabova Jekaterina , Rjabovs Vitālijs , Moreno Vargas Antonio , Clavijo Elena , Turks Māris 
Published: January 2012

Abstract
Recently, monosaccharide-triazole conjugates have proved to possess a large variety of useful biological activities. This paper describes synthesis of a new series of 3-deoxy-3-C-triazolylmethyl-allose derivatives. These new compounds are obtained from acetonide-protected 3-deoxy-3-azidomethyl allose and commercial alkynes via Cu(I) catalyzed 1,3-dipolar cycloaddition. The obtained molecular scaffolds differ from those described earlier by the presence of a methylene linker (-CH2-) between the C(3) of allose and the triazole moiety. It was demonstrated that acetonide-protected monosaccharide, 3-deoxy-3-C-(4-phenyl-1H-1,2,3-triazol-1-yl)methyl-1,2:5,6-di-O-isopropylidene-α-d-allofuranose, inhibited α-L-fucosidase for 26% at 0.1 mM concentration, but a deprotected analog, 3-deoxy-3-C-(4-(4-tert-butylphenyl)-1H-1,2,3-triazol-1-yl)methyl-β-d-allofuranose, showed 15% inhibition of β-glucosidase at 1 mM concentration.
Using the Integer Decorrelation Procedure to Increase of the Efficiency of the Mafa Method
Authors: Cellmer S. 
Published: January 2012

Using the Integer Decorrelation Procedure to Increase of the Efficiency of the Mafa MethodThe Modified Ambiguity Function Approach (MAFA) is a method of GNSS carrier phase processing. In this method, the functional model of the adjustment problem contains the conditions ensuring the "integerness" of the ambiguities. These conditions are expressed in the form of differentiable function. A prerequisite for obtaining the correct solution is a mechanism ensuring not only the "integerness" of the ambiguity but also appropriate localization of the search space in the place where the ambiguities have correct values. One of such mechanisms is cascade adjustment, applying the linear combinations of the signals L1 and L2 with the integer coefficients and various wavelengths. This paper presents another, independent from the previous, approach to increase the efficiency of the MAFA method. It is based on the application of the integer decorrelation matrix to transform observation equations into equivalent, but better conditioned, observation equations. The transformation matrix is obtained in the well-known ambiguity variance-covariance matrix integer decorrelation process.
The Humanitarian Relief Chain
Authors: İlhan Ali 
Published: January 2012

The Humanitarian Relief Chain
Supply Chain Management is a concept that originated and flourished in the manufacturing industry and has been subsequently adapted to many different areas. At present Disaster Management is one of those areas to which it has been adapted. Disaster Management is the set of rules for the coordination of activities at the disaster area and the rational usage of resources. During a disaster several logistics decisions should be made. The unpredictability of global emergencies (e.g., volcanic eruptions, earthquakes, floods) and the stakes of the adequate and timely delivery of the goods/services and challenge of managing material flow in the relief operations, which hold as their ultimate objective the delivery of the appropriate level of resources to locations worldwide in order to minimize human suffering and loss of life.
Insurance and Management of Political Risk Exposure in Developed Economies and Serbia
Authors: Ostojić Siniša , Unković Željka 
Published: January 2012

Insurance and Management of Political Risk Exposure in Developed Economies and SerbiaThe paper explores the risks, associated with government actions, which reduce the value of the company, in other words, a political risk. The purpose of this research is to determine the theoretical, institutional, regulatory management and implemented activities of political risks in different countries (the USA, the UK, France, Japan and Germany). The aim of this paper is the analysis of the characteristics of political risks, the analysis and the characteristics of the risk of the insurance policy from the standpoint of global, regional and state agencies and private insurers as well, determining the interdependence of political risks and country risks. The analysis begins by reviewing different ways of entering foreign markets (exports, foreign direct investment, contractual agreements and establishment of subsidiaries), all of which imply exposure to political risk. After that, political risk and exposure of its basic elements are defined, as well as methods that are applied in the assessment and the management of political risks. This paper concludes with an overview of political risk insurance coverage and sums insured in selected countries, and how political risk is underwritten and priced.
Technical Efficiency in the Small Scale Industrial Sectors of Punjab and Haryana - A Comparative Analysis
Authors: Kumar Satinder , Singh Parminder 
Published: January 2012

Technical Efficiency in the Small Scale Industrial Sectors of Punjab and Haryana - A Comparative AnalysisThe present study deals with the inter-temporal variations of technical efficiency in the small scale industrial sector of Punjab and Haryana and compares the performance of both states with the small scale industrial sector of India. Data spanning over the period 1972-73 to 2006-07 has been utilized to estimate technical efficiency with the help of data envelopment analysis (DEA) based upon efficiency scores. The empirical analysis confirms that there exists 0.176 percent and 0.470 percent technical inefficiency in the small scale industrial sectors of Punjab and Haryana, respectively. However, at the aggregated All-India level, the technical inefficiency score is 0.449. Thus, the small scale industrial sector of Punjab is comparatively more efficient than that of Haryana and All-India. Moreover, the reform process has adversely affected both the managerial and scale efficiencies of Haryana, whereas an improvement in managerial efficiency has been observed in the small scale industrial sectors of Punjab and All-India. The empirical analysis showed that in the post-reform period both at the All-India level and in Haryana technical inefficiency scores are increasing, whereas in Punjab it is decreasing. Thus, it can be inferred that scale efficiency is an important determinant of technical efficiency in explaining the performance of the small scale industrial sectors of Punjab and Haryana.
Comparison of remove-compute-restore and least squares modification of Stokes' formula techniques to quasi-geoid determination over the Auvergne test area
Authors: Yildiz H. , Forsberg R. , Ågren J. , Tscherning C. , Sjöberg L. 
Published: January 2012

Comparison of remove-compute-restore and least squares modification of Stokes' formula techniques to quasi-geoid determination over the Auvergne test areaThe remove-compute-restore (RCR) technique for regional geoid determination implies that both topography and low-degree global geopotential model signals are removed before computation and restored after Stokes' integration or Least Squares Collocation (LSC) solution. The Least Squares Modification of Stokes' Formula (LSMS) technique not requiring gravity reductions is implemented here with a Residual Terrain Modelling based interpolation of gravity data. The 2-D Spherical Fast Fourier Transform (FFT) and the LSC methods applying the RCR technique and the LSMS method are tested over the Auvergne test area. All methods showed a reasonable agreement with GPS-levelling data, in the order of a 3-3.5 cm in the central region having relatively smooth topography, which is consistent with the accuracies of GPS and levelling. When a 1-parameter fit is used, the FFT method using kernel modification performs best with 3.0 cm r.m.s difference with GPS-levelling while the LSMS method gives the best agreement with GPS-levelling with 2.4 cm r.m.s after a 4-parameter fit is used. However, the quasi-geoid models derived using two techniques differed from each other up to 33 cm in the high mountains near the Alps. Comparison of quasi-geoid models with EGM2008 showed that the LSMS method agreed best in term of r.m.s.
Regular design equations for the continuous reduced-order Kalman filter
Authors: Hippe Peter 
Published: January 2012

Regular design equations for the continuous reduced-order Kalman filter
Reduced-order Kalman filters yield an optimal state estimate for linear dynamical systems, where parts of the output are not corrupted by noise. The design of such filters can either be carried out in the time domain or in the frequency domain. Different from the full-order case where all measurements are noisy, the design equations of the reduced-order filter are not regular. This is due to the rank deficient measurement covariance matrix and it can cause problems when using standard software for the solution of the Riccati equations in the time domain. In the frequency domain the spectral factorization of the non-regular polynomial matrix equation does not cause problems. However, the known proof of optimality of the factorization result also requires a regular measurement covariance matrix. This paper presents regular (reduced-order) design equations for reduced-order Kalman filters in the time and in the frequency domains for linear continuous-time systems. They allow to use standard software for the design of the filter, to formulate the conditions for the stability of the filter and they also prove that the existing frequency domain solutions obtained by spectral factorization of a non-regular polynomial matrix equation are indeed optimal.
Optimal control problem for infinite variables hyperbolic systems with time lags
Authors: Bahaa Gaber , Tharwat Mohamed 
Published: January 2012

Optimal control problem for infinite variables hyperbolic systems with time lagsIn this paper, by using the theorems of [Lions (1971) and Lions & Magenes (1972)], the optimal control problem for distributed hyperbolic systems, involving second order operator with an infinite number of variables, in which constant lags appear both in the state equations and in the boundary conditions is considered. The optimality conditions for Neumann boundary conditions are obtained and the set of inequalities that characterize these conditions is formulated. Also, several mathematical examples for derived optimality conditions are presented. Finally, we consider an optimal distributed control problem for (nxn)-infinite variables hyperbolic systems.
Comparison between two approaches to modeling microsatellite DNA repeats: infinite dimensional model and its n-dimensional approximation
Authors: Białka Małgorzata 
Published: January 2012

Comparison between two approaches to modeling microsatellite DNA repeats: infinite dimensional model and itsn-dimensional approximationTwo approaches to modeling microsatellite DNA repeats are considered. The former is an infinite dimensional system based on the theory of branching random walks which dynamic properties are characterized using Laplace transforms and Laplace asymptotic techniques. The latter is ann-dimensional approximation where microsatellite DNA repeats model is the example of a chain system. Both models were the subject of many numerical calculations using the MATLAB software. The results allow us to evaluate the asymptotic behavior and determine the effect of the system parameters on the run of the solution and the state variables.
FPGA implementation of DPWM utility/DG interfaced solar (PV) power converter for green home power supply
Authors: Singh Shiva , Mishra Snehlata 
Published: January 2012

FPGA implementation of DPWM utility/DG interfaced solar (PV) power converter for green home power supply
In this paper, utility/DG interfaced DPWM solar (PV) power converter (SPC) has been proposed and developed to meet the growing green energy demand of household applications in a developing country like India. The use of new software based direct PWM strategy (DPWM) in the inverter circuit has resulted in to produce a very near sine-wave, most suitable for various home loads. Simulated results of proposed PWM output wave form and computation of its harmonics content in terms of THD value (upto 5% or even less) using MATLAB software has been reflected in the proposed scheme. The features like an intelligent control action to prevent battery from overcharge or undercharge, higher efficiency (> 90%), generation of grid quality green electricity, sustainability of solar renewable energy sources, cost effective hardware realization with FPGA based VLSI embedded system, shows the superiority of the proposed scheme over conventional power supply systems.
Two-dimensional CFD modeling of the heat and mass transfer process during sewage sludge drying in a solar dryer
Authors: Krawczyk Piotr , Badyda Krzysztof 
Published: January 2012

Two-dimensional CFD modeling of the heat and mass transfer process during sewage sludge drying in a solar dryer
The paper presents key assumptions of the mathematical model which describes heat and mass transfer phenomena in a solar sewage drying process, as well as techniques used for solving this model with the Fluent computational fluid dynamics (CFD) software. Special attention was paid to implementation of boundary conditions on the sludge surface, which is a physical boundary between the gaseous phase - air, and solid phase - dried matter. Those conditions allow to model heat and mass transfer between the media during first and second drying stages. Selection of the computational geometry is also discussed - it is a fragment of the entire drying facility. Selected modelling results are presented in the final part of the paper.