bluuebunny/crossref_metadata_2025_split huggingface dataset:
Text Comprehension Difficulties and Embodied Memory Processes
Authors: Lussiana Emeline , Versace Rémy , Sonnier Frédéric , Guéraud Sabine 
Published: May 2024

Abstract

The purpose of the present study was to investigate further the semantic processing impairments of less skilled comprehenders. It tested the hypothesis that this difficulty results from an alteration in the multimodal integration mechanism involved in knowledge emergence as described within multi-trace memory models. To test this assumption, Brunel et al.’s (2010) Experiment 2 was adapted for 27 skilled comprehenders and 32 less skilled comprehenders’ adolescents from the 7th and the 8th Grades. The experiment was divided into an integration phase and an experimental phase. During the integration phase, participants had to categorise two geometric shapes, one of which was systematically presented simultaneously with a white noise. To determine whether the white noise has been integrated as a feature of the shape, the experimental phase used a priming paradigm in which the shapes categorised previously were used as primes. The targets were objects that are usually associated with a sound or not. Participants had to categorise the targets’ size. The analysis that was carried out on the correct response times revealed that only skilled comprehenders showed the priming effect observed in adults in Brunel et al.: they were faster to categorise noisy objects when preceded by sound primes than by silent primes. These results suggest that less skilled comprehenders did not integrate the sound with the shape into memory during the integration phase, resulting later in difficulties in the emergence of the trace from memory. These findings are discussed within both embodied and memory-based approaches to reading comprehension.
QSHO: Quantum Spotted Hyena Optimizer for Global Optimization
Authors: Si Tapas , Miranda Pericles B.C. , Nandi Utpal , Jana Nanda , Maulik Ujjwal , Mallik Saurav , Qin Hong 
Published: May 2024

Abstract

Spotted Hyena Optimizer (SHO) is a population-based metaheuristic algorithm inspired by the spotted hyenas’ social behavior, and it is developed for solving global optimization problems. SHO has shown superior performance over its competitive metaheuristic algorithms in solving benchmark function optimization problems and engineering design problems. However, it suffers premature convergence in local optima due to its lack of exploration while solving multi-modal optimization problems. This article proposes an improved SHO, namely quantum SHO (QSHO), inspired by quantum computing. The QSHO implements a quantum computing mechanism to promote its exploration ability. The novel method is tested on well-known IEEE CEC2013 and IEEE CEC2017 benchmark suits with 30 and 50 dimensions and four real-world engineering optimization problems. The results of QSHO are compared with that of Classical SHO, improved SHO (ISHO), Modified SHO (MSHO), Oppositional SHO with mutation operator (OBL-MO-SHO), SHO with space transformation search (STS-SHO), Quantum Salp Swarm Algorithm (QSSA), and Chimp Optimization Algorithm (ChOA). The results are analyzed using the Wilcoxon Signed Rank Test (WSRT) and Friedman Test. The empirical results show that QSHO statistically outperforms other compared algorithms for both benchmark problem suits with both 30 and 50 dimensions. In addition, we have assessed the QSHO in four real-world engineering optimization problems and the QSHO statistically outperforms the competitive algorithms.
A descriptive, prospective cohort study of the somatic and psychological health impacts of immigration detention on asylum seekers and refugees
Authors: Sherif Bafreen , Hocking Debbie , Rees Susan , Sundram Suresh 
Published: May 2024

Abstract

Background
It is estimated that there are over 130 million forcibly displaced people worldwide, including refugees and asylum seekers. Some countries, such as Australia, have attempted to contain unplanned humanitarian flows using immigration detention. Globally, studies have consistently demonstrated the deleterious somatic and mental health impacts of immigration detention, with high levels of distress documented among detained refugees and asylum seekers. However, the cumulative and persistent effects of indeterminate immigration detention on the prospective somatic and mental health of refugees and asylum seekers are unclear and poorly quantified.
Method
This prospective, mixed-methods cohort study will recurrently assess the somatic and mental health of adult asylum seekers and refugees (ASR) with an experience of Australian Government-sponsored immigration detention greater than 28 days. ASR ≥ 18 years old released from immigration detention will be assessed at 0, 3, 6, and 12 months and annually thereafter for up to 10 years. Five self-report scales (HSCL-25, HTQ, WHODAS 2.0, BPI-SF, and PHQ-15) and the MINI Structured psychiatric interview will measure symptoms of depression, anxiety, post-traumatic stress, pain intensity and severity, somatic symptoms, and functional impairment. This study will describe the health profiles of individuals who were subjected to an indeterminate period of immigration detention. It will also identify emergent psychological disorders associated with detention, engagement in treatment, and the functional status of this cohort. Additionally, pre-existing health records will be accessed to identify current and previous health status and assess changes in these health indices.
Discussion
This is a cohort study with no comparable population described previously in the literature. As such, the data will provide invaluable information regarding the temporal health impacts of immigration detention associated with insecure visa status. These data may be used to inform health service planning and future policy formulation in national and international contexts with the potential to improve health outcomes for asylum seekers and refugees in host countries.
Public provision of healthcare and basic research: What are the joint effects on economic growth and welfare?
Authors: Parui Pintu , Prettner Klaus 
Published: May 2024

Abstract

We propose a generalized R&D-based economic growth model that incorporates endogenous human capital accumulation in terms of education and health and the public provision of healthcare and basic science. The government taxes households to pay for healthcare personnel and basic researchers. These employees are not anymore available for applied research and for final goods production. Thus, important intertemporal tradeoffs emerge for economic growth and welfare with respect to government spending policies. While increasing public spending on health and basic research may decrease economic growth and welfare in the short run, we show that they foster economic growth in the medium run and tend to raise long-run welfare when compared to actual levels of spending in Organisation for Economic Co-operation and Development (OECD) countries. Our results highlight the importance of adequate public funding for healthcare and basic research to foster long-run economic prosperity.
JEL Code: H41; J24; O31; O32; O41
Use of Spatiotemporal and Kinetic Gait Variables for the Differentiation of Hindlimb Ataxia and Bilateral Hindlimb Lameness in Dogs
Authors: Park Clair , Sawyere Dominique M. , Pancotto Theresa E. , Lanz Otto I. , Werre Stephen R. 
Published: May 2024

Abstract

Background
Discriminating the underlying cause of gait abnormalities can be challenging in a clinical setting, especially in the presence of bilateral disease. Pressure-sensitive walkways (PSWs) have been utilized to characterize the gait of dogs with various neurologic or orthopaedic conditions. The potential use of the PSW includes the discrimination of conditions that can be similar in clinical presentation, such as bilateral hindlimb lameness and hindlimb ataxia. The primary aim of this study was to describe the spatial, temporal, and kinetic gait parameters of dogs with hindlimb ataxia or bilateral hindlimb lameness and compare them to those of normal dogs. The secondary aim of this study was to identify specific gait parameters that could be used to discriminate the two conditions. Forty-six dogs were prospectively recruited. The normal group included 20 dogs with normal neurologic and orthopaedic exams. The orthopaedic group included 15 dogs with bilateral hindlimb orthopaedic diseases with weight-bearing hindlimb lameness and normal neurologic exams. The neurologic group included 11 dogs with ambulatory paraparesis and normal orthopaedic exams. Each dog was walked across the PSW, and at least 3 valid trials were collected. The stride time, stance time, swing time, stride length, gait velocity, peak vertical force (PVF), vertical impulse (VI), and limb symmetry values were recorded. The mean values of all parameters from the valid trials were calculated and used for data analysis. The outcomes were compared among all groups, and statistical significance was set to p < 0.05.
Results
Compared with the normal group, the orthopaedic group had a significantly greater percent body weight distribution (%BWD) and vertical impulse distribution (VID) in the forelimbs. There were no significant differences in the kinetic parameters or weight distribution between the neurologic group and the normal group. When comparing the symmetric indices (SIs) of the spatiotemporal gait parameters, the neurologic group showed an increase in forelimb stance time compared to that of the normal group (p = 0.02). Compared with that in the normal group, the stride velocity in the forelimbs in the orthopaedic group was greater (p = 0.009). There were no significant differences in the SI of stride time or stride length among the groups.
Conclusion
The kinetic and spatiotemporal gait parameters obtained by PSW demonstrated that the orthopaedic and neurologic groups may have different compensatory mechanisms for their gait deficiencies. These gait parameters can potentially be used to construct a predictive model to evaluate PSW as a diagnostic tool to differentiate between the two conditions.
Analysis of DHX32 as diagnostic gene and independent prognostic factor of lung squamous cell carcinoma
Authors: cao wei , Zuo Zhuang , Jin Dacheng , Li Haochi , Min Weirun , Zhang Jinlong , Lin Zhaohao , Gou Yunjiu 
Published: May 2024

Abstract

Background: The abnormal of DHX32 was related to the occurrence, development and clinicopathological features of cancer, but DHX32 has not been studied in Lung squamous carcinoma (LUSC). We aimed to investigate the expression , prognosis and biological significance of DHX32 in LUSC.
Method: The LUSC-related datasets (GSE30219 and GSE8894) were included in the analysis. Firstly, the expression and diagnosis of DHX32 were analyzed. The differentially expressed genes (DEGs) of GSE30219 were screened. The Cox analysis was used to screen prognostic genes. Based on the risk scores of LUSC samples, the samples were divided into high-low risk groups. The risk model was constructed by cox analysis in GSE30219, and verified in GSE8894. Furthermore, nomogram, immune infiltration analysis and drug sensitivity analysis were constructed.
Results: Compared with the control group, the expression of DHX32 in LUSC samples was obviously higher. The survival of high truncation value group was signally higher than that of low truncation value group. Based on 347 DEGs, the 3 prognostic genes (CLDN11, PID1 and MAMDC2) were screened. In GSE30219 and GSE8894, the risk model had high accuracy and excellent performance. In addition, the riskScore was independent prognostic risk factors for LUSC by cox analysis. Immune infiltration analysis and drug sensitivity analysis showed that memory B cells and five drug had a difference in two risk groups.
Conclusion: DHX32 could be used as a diagnostic gene and independent prognostic factor for LUSC, providing the insight for the diagnosis and treatment of LUSC.
Proton relay in hydrogen-bond networks promotes alkaline hydrogen evolution electrocatalysis
Authors: Li Jiayuan , Li Yuefei , Zhang Shishi , Li Boyang , Su Yaqiong 
Published: May 2024

Abstract

Common O-/H-down orientation of H2O molecules on electrocatalysts brings favorable OH/H delivery however adverse H/OH delivery in their dissociation process, hampering H2O dissociation kinetics of alkaline hydrogen evolution reaction (HER). To overcome this challenge, we raised a synergetic H2O dissociation concept of metal-supported electrocatalysts involving efficient OH delivery from O-down H2O to the metal, timely proton relay from O-down H2O on the metal to H-down H2O on the support through the hydrogen-bond network, and prompt H delivery from H-down H2O to the support. After theoretically profiling that a high work function difference between metal and support (ΔΦ) induces a strong electric field at the metal-support interface that increases hydrogen-bond connectivity to promote proton relay, we examined this concept over cobalt phosphide-supported ruthenium (Ru/CoP) catalysts with a high ΔΦ = 0.4 eV, reaching record high HER performance with a Ru utilization activity of 66.1 A mgRu-1 at a 100 mV overpotential.
Chlorpromazine Overcomes Temozolomide Resistance in Glioblastoma by inhibiting Cx43 and Essential DNA Repair Pathways
Authors: Matarrese Paola , Signore Michele , Ascione Barbara , Fanelli Giulia , Paggi Marco G. , Abbruzzese Claudia 
Published: May 2024

Abstract

Background
In the fight against GBM, drug repurposing emerges as a viable and time-saving approach to explore new treatment options. Chlorpromazine, an old antipsychotic medication, has recently arisen as a promising candidate for repositioning in GBM therapy in addition to temozolomide, the first-line standard of care. We previously demonstrated the antitumor efficacy of chlorpromazine and its synergistic effects with temozolomide in suppressing GBM cell malignant features in vitro. This prompted us to accomplish a Phase II clinical trial to evaluate the efficacy and safety of adding chlorpromazine to temozolomide in GBM patients with unmethylated MGMT gene promoter. In this in vitro study, we investigate the potential role of chlorpromazine in overcoming temozolomide resistance.
Methods
In our experimental set, we analyzed Connexin-43 expression at both the transcriptional and protein levels in control- and chlorpromazine-treated GBM cells. DNA damage and subsequent repair were assessed by immunofluorescence of g-H2AX and Reverse-Phase Protein microArrays in chlorpromazine treated GBM cell lines. To elucidate the relationship between DNA repair systems and chemoresistance, we analyzed a signature of DNA repair genes in GBM cells after treatment with chlorpromazine, temozolomide and Connexin-43 downregulation.
Results
Chlorpromazine treatment significantly downregulated connexin-43 expression in GBM cells, consequently compromising connexin-dependent cellular resilience, and ultimately contributing to cell death. In line with this, we observed concordant post-translational modifications of molecular determinants involved in DNA damage and repair pathways. Our evaluation of DNA repair genes revealed that temozolomide elicited an increase, while chlorpromazine, as well as connexin-43 silencing, a decrease in DNA repair gene expression in GBM cells.
Conclusions
Chlorpromazine potentiates the cytotoxic effects of the alkylating agent temozolomide through a mechanism involving downregulation of Cx43 expression and disruption of the cell cycle arrest essential for DNA repair processes. This finding suggests that chlorpromazine may be a potential therapeutic strategy to overcome TMZ resistance in GBM cells by inhibiting their DNA repair mechanisms.
Diurnal cycle of bioaerosols is a key driver of ice nucleating particle variability for Eastern Mediterranean orographic clouds
Authors: Gao Kunfeng , Vogel Franziska , Foskinis Romanos , Vratolis Stergios , Gini Maria , Granakis Konstantinos , Zografou Olga , Fetfatzis Prodromos , Papayannis Alexandros , Möhler Ottmar , Eleftheriadis Konstantinos , Nenes Athanasios 
Published: May 2024

Abstract

We report the drivers of diurnal cycles of ice nucleating particles (INPs) for mixed-phase orographic clouds in the Eastern Mediterranean. In the planetary boundary layer, pronounced INP diurnal periodicity is observed, which is mainly driven by coarse-sized particles. Based on particle fluorescence, we estimate at least 20% of the INPs in the PBL are of biological origin and a major driver of the diurnal cycle. The presence of Saharan dust increases INPs during nighttime but not for daytime compared to non-dust days, thus reducing the INP range throughout the day. Bioaerosols also are important contributors to INP in the free troposphere without any evident diurnal cycle. Given the ubiquity of forests in mountainous regions, the unique ability of bioaerosol to form ice at warm temperatures (effects of which is further amplified by secondary ice processes) and the lack of such cycles in models points to an overlooked glaciation cycle and an important source of bias in precipitation and extreme events in continental and mountainous regions.
Wild rodent fleas carrying Bartonella and Rickettsia in an area endemic for vector-borne diseases: implications for public health in northwestern Argentina
Authors: Berrizbeitia M. Fernanda López , Acosta Diana B. , Sanchez Juliana P. 
Published: May 2024

Abstract

Vector-borne illnesses account for nearly 20% of all globally recognised infectious diseases. Within the spectrum of pathogens transmitted by fleas, Bartonella and Rickettsia bacteria are prominent, contributing to the emergence and resurgence of diseases on a global scale. This study aimed to investigate the presence of specific strains of Bartonella and Rickettsia species harboured by fleas collected from wild rodents in Northwestern Argentina. A total of 28 fleas from three genera and seven species were assessed. DNA of Bartonella and Rickettsia spp. was found in 12 fleas (42.8%). Phylogenetic analysis of concatenated sequences of gltA and rpoB genes showed the presence of Bartonella quintana in eight fleas of two species, Craneopsylla minerva minerva and Polygenis acodontis; Phylogenetic analysis of concatenated sequences of gltA, ompA and ompB genes identified Rickettsia felis in ten fleas of five species, C. m. minerva, P. acodontis, Polygenis bohlsi bohlsi, Polygenis byturus and Tiamastus palpalis. These bacterial species marking the first report in all flea species studied. This study represents the first survey of flea-borne bacteria for Northwest Argentina. The results provide information to address strategies for the control and prevention of bartonellosis and rickettsiosis that could have an impact on public health in one of the geographical areas of Argentina with the highest incidence of infections transmitted to humans by ectoparasites.
Contribution of Simulation in Paediatric Laparoscopic Surgery: Improving Suturing Skills Before Performing a Laparoscopic Procedure in Children
Authors: BIDAULT-JOURDAINNE Valeska , BREAUD Jean , ALI Liza , TALON Isabelle , BECMEUR François , EL-GHONEIMI Alaa , PEYCELON Matthieu 
Published: May 2024

Abstract

Introduction: Mastering paediatric laparoscopic surgery competency (PLSC) is technically challenging. The present study aimed to determine whether the inter-academic PLSC degree (IAD_PLSC) practical training program enables trainees to improve their skills.
Methods: This retrospective study included trainees enrolled in the IAD_PLSC program in 2021 and 2022 which included two separate 15 hour-sessions. Trainees practiced to perform intracorporeal laparoscopic knots (ILK) using 5- and 3-mm instruments on a pelvi-trainer simulator; Peg Transfer (PT) was used as a dexterity test; final marks added the adapted Objective Structured Assessment of Technical Skills (OSATS) score (out of 40) and time to complete ILK. ILK was considered a success in case the OSATS score > 27/40.
Results: A total of 43 trainees completed the IAD_PLSC program. N = 37 (86.0%) mastered the ILK (OSATS score > 27/40) using 5-mm instruments at the end of session 1 and N = 33 (76.7%) at the end of session 2 (p = 0.41). There was no significant improvement in the median [interquartile range, IQR] OSATS score (32 [30–36] vs. 32 [28–34], p = 0.19), but the median [IQR] knot completion time improved significantly (184 s [161–268] vs. 166 s [128–218], p = 0.002). There was a significant correlation between the knot completion time and PT time both at the end of session 1 (ρ = 0.58, 95% confidence interval, CI [0.31;0.76], p < 0.0002) and session 2 (ρ = 0.78, 95%CI [0.62;0.87], p < 0.0001). When using 3-mm instruments, N = 34 (79.1%) of trainees mastered the ILK at the end of session 2. The median [IQR] OSATS score significantly improved between the end of both sessions (22 [21–24] vs. 31 [28–33], p < 0.0001), but there was no significant correlation between OSATS score or knot completion time and PT time, at the end of both sessions.
Conclusion: A nation-wide training program in paediatric laparoscopic surgery provides valuable practical training of intracorporeal suturing for residents in pediatric surgery and urology.
Research on Origin-based Cold Storage Location and Routing Optimization of Fresh Agricultural Products Based on Hybrid Whale Algorithm
Authors: Zhou Xueyan , Li Jin , Xie Fengjie , Fang Jing 
Published: May 2024

Abstract

Aiming at the problem that the number of origin-based cold storages is insufficient and the resources are unbalanced in China, this paper studies the location and routing problem (LRP) of origin-based cold storage for fresh agricultural products. This paper considers the loss of fresh agricultural products, and constructs a cold storage LRP model. To solve this problem, a hybrid whale algorithm is designed, and the effectiveness of the algorithm is verified by standard instances. Finally, taking Chenggu County as a practical case, the influence of cold storage capacity and farmers demand for refrigeration on LRP are analysed. Experimental results show that the algorithm proposed in this paper has a good effect in solving the medium-scale LRP. The cold storage capacity has an important impact on the LRP results. With the increase of farmers’ demand for refrigeration, the number of cold storages and vehicles increases, the total system costs increase gradually.
Scientometric Insights of Digital Twins in Industry 4.0
Authors: Kaur Harshpreet , Bhatia Munish 
Published: May 2024

Abstract

Industry 4.0 is a new era of digitization that integrates digital technologies to create smart, interconnected production systems, marking a paradigm shift in different domains. One of the key technologies in this era is 'Digital Twin', which offers virtual representations of physical assets and processes. It is crucial to analyze the role of digital twin technology in the context of Industry 4.0 using scientometric analysis with citeSpace, a powerful tool for visualizing and analyzing citation networks. This research focuses on the growth trajectory of digital twin literature, identifies influential authors, institutions, and journals, and analyzes the geographical distribution of research contributions from the Scopus database for 2018-2024. The findings reveal insights into the current state of digital twin research, its impact on Industry 4.0, and opportunities for future exploration and collaboration in this rapidly evolving field.