bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tetrafluoroethylation of Electron‐Rich Alkenyl Iodides Enabled by in situ Generation of Solvent‐Stabilized “Ligandless” CuCF2CF2H
Authors: Segovia Cristina M. , Porto Luana L. T. N. , Casasús Paula , Bascuas Isabel , Ahmad Amena , Mestre Jordi , Bernús Miguel , Castillón Sergio , Baker R. Tom , Boutureira Omar 
Published: April 2024

AbstractIn this study, we have developed a metal‐mediated synthetic method for incorporating the 1,1,2,2‐tetrafluoroethyl (CF2CF2H) motif into unactivated, electron‐rich alkenyl iodides using cross‐coupling reactions. We discovered that the stable Cu(CF2CF2H)(PPh2Me)3 complex, while unreactive with these substrates, serves as a P‐ligated reservoir for the formation of solvent‐stabilized “ligandless” and reactive CuCF2CF2H species. This transformation occurs upon addition of CuBr, which partially scavenges the P‐ligand in the form of CuBr(PPh2Me)3. The resulting in situ generated solvent stabilized “ligandless” system significantly enhances the reactivity of the complex, particularly towards challenging electron‐rich substrates. This advancement enables the synthesis of HCF2CF2‐glycals, as well as nucleosides/nucleobases and arenes.
Recent Advances in the Use of α‐Azidochalcones in Heterocycle Synthesis
Authors: Devi Newar Uma , Jyoti Boruah Dhruba , Awatar Maurya Ram 
Published: April 2024

Abstractα‐Azidochalcones have emerged as remarkably versatile precursors within organic azides, showcasing a broad spectrum of reactivity as a cornerstone for synthesizing diverse molecular scaffolds. The ongoing progress in this field has opened new opportunities for constructing complex organic molecules through diverse chemical transformations due to the versatile reactivity of α‐azidochalcones for further functionalization. The comprehensive review presented herein provides a concise yet detailed examination of the synthesis, reactivity, and potential applications of α‐azidochalcones. Focusing on both thermal and photochemical pathways, this review highlights the versatility of α‐azidochalcones as pivotal precursors in the synthesis of various heterocyclic frameworks.
Synthesis of Bridged Bicyclic Systems peri‐Annulated to the Indole Ring: Tropane‐Fused Indoles
Authors: Antropov Sergey M. , Tokmacheva Sofiya A. , Levina Irina I. , Ivanova Olga A. , Trushkov Igor V. 
Published: April 2024

AbstractYtterbium triflate catalysed domino reaction of (3‐formyl‐4‐indolyl)‐derived donor‐acceptor cyclopropane with primary amines provides a simple approach to an unprecedented tetracyclic skeleton in which tropane system is peri‐annulated with an indole core. This process involves the formation of an imine and its (3+2)‐cross‐cycloaddition with donor‐acceptor cyclopropane moiety, yielding tropane‐fused indole core under mild reaction conditions. These products are of significant interest for pharmacology as potential hybrid molecules with a dual mode of action.
Electrode, Electrolyte, and Membrane Materials for Electrochemical CO2 Capture
Authors: Sun Kaige , Tebyetekerwa Mike , Zhang Hongxia , Zeng Xiangkang , Wang Zhuyuan , Xu Zhen , Rufford Thomas E. , Zhang Xiwang 
Published: April 2024

AbstractOne of the many possible ways to capture carbon dioxide (CO2) is through electrochemical means. This is an emerging approach with various merits. It is energy efficient, utilizes renewable energy, operates under ambient conditions, provides ease for control of reaction rates, and is scalable. Additionally, it can be integrated as a plug‐and‐play module at various scales, including large industrial sources or at small scale, e.g., on vehicles, and can easily combine CO2 capture, storage, and utilization into value‐added chemicals. Various “proof‐of‐concept” electrochemical CO2 capture approaches have been demonstrated in the recent past. These are made possible with electro‐active materials that capture, separate, and concentrate CO2 in the form of electrodes, electrolytes, and membranes in devices. Herein, these materials and their working mechanisms are identified and reviewed in various electrochemical CO2 capture devices where they are utilized. Also, the current challenges and future research directions with the identified electrodes, electrolytes, and membranes are summarized to give a rational understanding and guidance for selecting and designing materials for use in electrochemical CO2 capture devices.
Significance of blood culture testing after pancreatoduodenectomy
Authors: Aritake Tsukasa , Natsume Seiji , Asano Tomonari , Okuno Masataka , Itoh Naoya , Matsuo Keitaro , Ito Seiji , Komori Koji , Abe Tetsuya , Shimizu Yasuhiro 
Published: April 2024

AbstractAimThe aim of this study was to clarify the significance of blood culture testing in the postoperative period of pancreatoduodectomy (PD), a highly invasive surgery.MethodsRates of blood culture sampling and positivity were investigated for febrile episodes (FEs) in patients who underwent PD (2016–2021). FEs were defined as body temperature of 38.0°C or higher occurring on or after the 4th postoperative day. Fever origin was diagnosed retrospectively, and FEs were classified as pancreatic fistula (PF)‐related or PF‐unrelated FEs. Factors correlated with blood culture positivity were explored.ResultsAmong 339 patients who underwent PD, 99 experienced 202 FEs. Blood culture testing was performed on 160 FEs occurring in 89 patients. The sampling and positivity rates were 79.2% and 17.5%, respectively, per episode and 89.9% and 28.1%, respectively, per patient. Thirty‐six FEs were classified as PF‐related and 124 were classified as PF‐unrelated FEs. The blood culture positivity rate was significantly lower in PF‐related vs. PF‐unrelated FEs (1/36 vs. 27/124, respectively, p = 0.006). The blood culture positivity rate was significantly higher in patients with cholangitis, catheter‐related blood stream infection, and urinary tract infection than PF‐related FEs. Multivariate analysis showed that blood culture positivity was negatively associated with PF‐related FEs and positively associated with accompanying symptoms of shivering, Pitt Bacteremia Score, and preoperative biliary drainage.ConclusionsPatients who underwent PD showed relatively high blood culture positivity rates. Based on these results, it may be possible to distinguish PF‐related and ‐unrelated FEs.
Design and operation of modular biorefinery supply chain under uncertainty using generalized Benders decomposition
Authors: Luo Yuqing , Ierapetritou Marianthi 
Published: April 2024

AbstractBiomass supply chain performance is heavily affected by uncertainties stemming from supply, demand, or unexpected disruptions. Unlike petrochemical plants that use crude oil, biorefineries often have to deal with the uneven spatial‐temporal distribution of feedstock supply. The modular production strategy provides more flexibility in chemical manufacturing by allowing fast capacity expansion and unit movement. However, modeling and optimizing modular biomass supply chain under uncertainties becomes challenging due to high dimensionality and the existence of discrete decisions. This work optimizes the multiperiod biomass supply chain using the rolling horizon planning and two‐stage stochastic programming framework. We then applied generalized Benders decomposition to reduce the computational complexity of the stochastic mixed integer nonlinear programming supply chain optimization. Furthermore, the solution of the stochastic programming could be used to quantitatively describe the life‐cycle assessment uncertainties of the biomass supply chain performance, demonstrating seasonality and random variability.
Leveraging DNA methylation to predict treatment response in major depressive disorder: A critical review
Authors: Dahrendorff Jan , Currier Glenn , Uddin Monica 
Published: April 2024

AbstractMajor depressive disorder (MDD) is a debilitating and prevalent mental disorder with a high disease burden. Despite a wide array of different treatment options, many patients do not respond to initial treatment attempts. Selection of the most appropriate treatment remains a significant clinical challenge in psychiatry, highlighting the need for the development of biomarkers with predictive utility. Recently, the epigenetic modification DNA methylation (DNAm) has emerged to be of great interest as a potential predictor of MDD treatment outcomes. Here, we review efforts to date that seek to identify DNAm signatures associated with treatment response in individuals with MDD. Searches were conducted in the databases PubMed, Scopus, and Web of Science with the concepts and keywords MDD, DNAm, antidepressants, psychotherapy, cognitive behavior therapy, electroconvulsive therapy, transcranial magnetic stimulation, and brain stimulation therapies. We identified 32 studies implicating DNAm patterns associated with MDD treatment outcomes. The majority of studies (N = 25) are focused on selected target genes exploring treatment outcomes in pharmacological treatments (N = 22) with a few studies assessing treatment response to electroconvulsive therapy (N = 3). Additionally, there are few genome‐scale efforts (N = 7) to characterize DNAm patterns associated with treatment outcomes. There is a relative dearth of studies investigating DNAm patterns in relation to psychotherapy, electroconvulsive therapy, or transcranial magnetic stimulation; importantly, most existing studies have limited sample sizes. Given the heterogeneity in both methods and results of studies to date, there is a need for additional studies before existing findings can inform clinical decisions.
One‐Step and Mild Synthesis of 3‐(1,3,4‐Oxadiazol‐2‐Yl)isoindolin‐1‐Ones Through Ugi Four‐Component Domino Dicyclization
Authors: Sun Mei , Zeng Chong‐Yang , Zhang En‐Shen , Zhang Qiang , Chen Kai , Xu Yu‐Gu , Fan Mei‐Xia , He Meng‐Ru , Shi Jing‐Hui , Ding Ming‐Wu 
Published: April 2024

AbstractA novel and efficient Ugi four‐component domino dicyclization strategy has been developed for one‐step constructing diverse 3‐(1,3,4‐oxadiazol‐2‐yl)isoindolin‐1‐ones with good yields, without the need for additional additives. This domino dicyclization process underwent three consecutive reactions including Ugi, aza‐Wittig and N‐acylation by utilizing (N‐isocyanimine)triphenylphosphorane, methyl 2‐formylbenzoate, primary amines, and carboxylic acids. The initial biological activity testing revealed that compound 5 i exhibited good antifungal activity against certain fungi and demonstrated versatile applications in the fields of pesticide chemistry.
Tuning CpG motif position in nanostructured DNA for efficient immune stimulation
Authors: Tan Mengmeng , Makiguchi Natsuki , Kusamori Kosuke , Itakura Shoko , Takahashi Yuki , Takakura Yoshinobu , Nishikawa Makiya 
Published: April 2024

AbstractIt was previously demonstrated that polypod‐like nanostructured DNA (polypodna) comprising three or more oligodeoxynucleotides (ODNs) were useful for the delivery of ODNs containing cytosine–phosphate–guanine (CpG) motifs, or CpG ODNs, to immune cells. Although the immunostimulatory activity of single‐stranded CpG ODNs is highly dependent on CpG motif sequence and position, little is known about how the position of the motif affects the immunostimulatory activity of CpG motif‐containing nanostructured DNAs. In the present study, four series of polypodna were designed, each comprising a CpG ODN with one potent CpG motif at varying positions and 2–5 CpG‐free ODNs, and investigated their immunostimulatory activity using Toll‐like receptor‐9 (TLR9)‐positive murine macrophage‐like RAW264.7 cells. Polypodnas with the CpG motif in the 5′‐overhang induced more tumor necrosis factor‐α release than those with the motif in the double‐stranded region, even though their cellular uptake were similar. Importantly, the rank order of the immunostimulatory activity of single‐stranded CpG ODNs changed after their incorporation into polypodna. These results indicate that the CpG ODN sequence as well as the motif location in nanostructured DNAs should be considered for designing the CpG motif‐containing nanostructured DNAs for immune stimulation.
Research advances and trends in anatomy from 2013 to 2023: A visual analysis based on CiteSpace and VOSviewer
Authors: Du Yikuan , Cai Xiaolin , Zheng Ye , Long Aoxue , Zhang Mengting , Chen Mianhai , Zhang Weichui , Zhu Jinfeng , Guo Jinhua , Yang Chun 
Published: April 2024

AbstractAs the cornerstone of medicine, the development of anatomy is related to many disciplines and fields and has received extensive attention from researchers. How to integrate and grasp the cutting‐edge information in this field quickly is a challenge for researchers, so the aim of this study is to analyze research in anatomy using CiteSpace and VOSviewer in order to identify research hotspots and future directions. To offer a fresh viewpoint for assessing the academic influences of researchers, nations, or institutions on anatomy, and to examine the development of hotspots in anatomical study and to forecast future trends. A total of 4637 anatomy‐related publications from 2013 to 2023 were collected from Web of Science Core Collection databases. Their temporal distribution, spatial distribution, cited authors, co‐cited journals, keywords, and disciplinary connections in the literature were analyzed using CiteSpace and VOSviewer, and a knowledge graph was constructed. The temporal distribution shows a general fluctuation in the amount of literature published from 2013 to 2023. In spatial distribution, the total number of published articles was highest in the United States, the United Kingdom, and China, the United States leading. Tubbs, Rhoton, Iwanaga, and LaPrade are important authors in anatomy. Clinical Anatomy, Surgical and Radiologic Anatomy, and Journal of Anatomy were the most highly cited journals. Analysis of keywords and citation emergence showed that the research hotspots and trends in anatomy focused mainly on anatomy education, digital technology, and surgical management. At the same time, anatomy showed a trend toward multidisciplinary crossover, developing closer relationships with molecular biology, immunology, and clinical medicine. Current research in anatomy focuses on innovative reform of the educational model and the application and promotion of digital technology. Also, multidisciplinary cross‐fertilization is an inevitable trend for the future development of anatomy.
Effectiveness and infectious complications of BCMA T‐cell engagers in treating multiple myeloma: Real‐world evidence from Sweden
Authors: Uttervall Katarina , Tätting Love , Lemonakis Konstantinos , Majd Mousa , Crafoord Jacob , Olsson Mikael , Mellqvist Ulf‐Henrik , Hansson Markus , Nahi Hareth 
Published: April 2024

AbstractBackgroundMultiple myeloma (MM), an incurable disease characterized by frequent relapses and a need for multiple treatments, often progresses to a relapse/refractory status resistant to all available drugs and drug classes. Bispecific antibodies, specifically BCMA T‐cell engagers, have emerged as effective treatments for MM, demonstrating impressive efficacy. However, these treatments can adversely affect the immune system, increasing vulnerability to infections.Methods/ResultsThis study evaluated the efficacy and safety of BCMA T‐cell engagers in 58 Swedish patients with poor MM prognosis. The patients exhibited a 69% overall response rate, with 69% survival and 60% progression‐free survival at 15 months.ConclusionsDespite the risk of infectious complications, the prognosis of MM patients can be significantly improved with vigilant monitoring and proactive management of infections. This real‐world data highlight the potential of BCMA T‐cell engagers in treating MM, emphasizing the need for careful patient monitoring to mitigate infection risks.
Effects of resistance training on sleep quality and disorders among individuals diagnosed with cancer: A systematic review and meta‐analysis of randomized controlled trials
Authors: Maric Dora , Ficarra Salvatore , Di Bartolo Luca , Rossi Carlo , Asimakopoulou Zoi , Vantarakis Apostolos , Carbonell‐Baeza Ana , Jiménez‐Pavón David , Gomes Beatriz , Tavares Paula , Baxter Rebecca , Pusa Susanna , Thaller Petra , Papakonstantinou Sofia , Kirkar Musa , Glorioso Francesca , Galioto Marina , Gentile Ambra , Thomas Ewan , Bianco Antonino 
Published: April 2024

AbstractBackgroundSleep disorders are often complained by cancer patients and can last years after the end of therapies, leading to different negative consequences. Non‐pharmacological strategies such as exercise interventions may be considered to counteract this phenomenon. The literature supports the beneficial effects of aerobic training (AT), while evidence on resistance training (RT) is scarce. Accordingly, our systematic review aims to investigate the potential novel effect of RT on sleep outcomes in cancer survivors.MethodsThe literature search was conducted on MEDLINE (Pubmed), Web of Science, Scopus, and Cochrane Central Register of Controlled Trials databases, including only randomized controlled trials (RCTs). The screening procedure was conducted using the web‐based software COVIDENCE. Sleep outcomes assessed through self‐reported questionnaires or objective sleep measurements were extracted from RCTs recruiting cancer survivors of any age and gender, on or off treatment. The risk of bias (RoB) for each study was assessed using the Cochrane RoB 2 tool for RCTs. Meta‐analytic syntheses were performed on sleep quality and insomnia.ResultsA total of 21 studies were included in the review. Considering the mean percentage differences of all studies combined, promising positive results were found after combined aerobic and resistance exercise program (COMB) for sleep quality (−19%) and sleep disturbance (−17.3%). The meta‐analysis results showed significant improvement for both sleep quality and insomnia (d = 0.28, SE: 0.11, Z = 2.51, p < 0.01, 95% CI: 0.07–0.49 and d = 0.43, SE: 0.20, Z = 2.18, p = 0.029, 95% CI: 0.07–0.49, respectively).ConclusionRT interventions of 60 minutes per session, performed 2–3 times a week for 12 weeks, with exercise intensity ranging from 60% to 80% of one‐repetition maximum can be administered to cancer survivors, aiming to improve sleep outcomes.
Cu, Fe, N‐doped Carbon Nanotubes Prepared through Silica Coating for Selective Oxygen Reduction to Water in Acidic Media
Authors: Kato Masaru , Abe Daiki , Xie Siqi , Sato Shun , Fujibayashi Natsuki , Matsumoto Koki , Onoda Akira , Hayashi Takashi , Mitsui Takaya , Fujiwara Kosuke , Yamamoto Takashi , Einaga Yasuaki , Tadgell Colin A. , Kato Yuta , Asakura Kiyotaka , Yagi Ichizo 
Published: April 2024

AbstractWe report Cu, Fe, N‐doped carbon nanotubes, (Cu,Fe)−N−CNT, as electrocatalysts for the oxygen reduction reaction (ORR) in acidic media. (Cu,Fe)−N−CNT was prepared using a silica coating method in pyrolysis to minimize the formation of carbon‐coated metal oxide or carbide nanoparticles, which are known to be inactive for the H2O2 reduction. (Cu,Fe)−N−CNT shows a turnover frequency of 0.66 e− site−1 s−1 at +0.8 V vs. RHE and H2O2 yields of <1 % for the ORR with a utilization factor of active sites of 82 %. Kinetic analysis reveals that 4e− transfer rates for (Cu,Fe)−N−CNT are higher than those of a monometallic counterpart of Fe−N−CNT. In situ X‐ray absorption spectroscopy enables us to determine redox potentials: E°’(FeIII/FeII)=0.65 V vs. RHE and E°’(CuII/CuI)=0.45 V for (Cu,Fe)−N−CNT, and E°’(FeIII/FeII)=0.65 V for Fe−N−CNT. These results indicate that bimetallic doping into carbon nanotubes gives the effect on kinetic parameters but not on thermodynamic ones. In other words, there is no direct electronic interactions between the Cu and Fe active sites for (Cu,Fe)‐N‐CNT because such interactions should modulate their redox potentials.
Dual Basicity and Nucleophilicity of Organosodium Reagents in Benzylic C−H Additions of Toluenes to Diarylethenes and Ketones
Authors: Anderson David E. , Truong Alex H. N. , Hevia Eva 
Published: April 2024

AbstractProfiting from the dual high basicity and nucleophilicity of organosodium complexes, here we report the stepwise lateral metalation of a wide range of alkyl arenes (MeAr), mediated by hydrocarbon‐soluble NaCH2SiMe3 ⋅ PMDETA (PMDETA=N,N,N’,N’’,N’’‐pentamethyldiethylenetriamine), followed by nucleophilic addition to diarylethenes of the newly generated NaCH2Ar ⋅ PMDETA complexes. This method grants access to a range of functionalised hydrocarbons in excellent yields and can be upgraded to catalytic regimes when using trans‐stilbene, a 10 mol% of the alkyl sodium base and toluene as a solvent. Extending this approach to aromatic ketones leads to the formation of stilbenes under mild reaction conditions, resulting from the deprotonative coupling of toluenes with ketones. Combining spectroscopic studies with the trapping and characterisation of key reaction intermediates, mechanistic insights have been gained, advancing the understanding of coordination effects in organosodium chemistry, and shedding light on their special reactivity profiles.
Optical Upconversion in Mononuclear Lanthanide Co‐Crystal Assemblies
Authors: Wang Yuxin , Sun Guotao , Su Qichen , Xie Yao , Xing Feifei , Zhang Hongjie , Sun Lining 
Published: April 2024

AbstractIn this work, we developed two kinds of co‐crystal assemblies systems, consisting of discrete mononuclear Yb3+ and Er3+ and mononuclear Yb3+ and Pr3+, which can achieve Er3+ and Pr3+ upconversion luminescence, respectively, by Yb3+ sensitization under 980 nm excitation. The structure and composition of two co‐crystal assemblies were determined by single crystal X‐ray diffraction. By investigation of the series of two assemblies, respectively, it is found that the strongest upconversion luminescence is both obtained when the molar ratio of Yb3+ and Ln3+ (Ln=Er or Pr) is 1 : 1. The energy transfer mechanism of Er3+ assemblies is determined as energy transfer upconversion, while that of Pr3+ assemblies is determined as energy transfer upconversion and cooperative sensitization upconversion. This is the first example of Pr3+ upconversion luminescence at the molecular dimension at room temperature, which enriches the research in the field of upconversion luminescence with lanthanide complexes.
An S‐Scheme AgIn5S8/Bi2MoO6 Heterojunction for the Photocatalytic Degradation of Hydrochloride Tetracycline
Authors: Yao Xiaoqian , Teng Feng , Yang Tao , Hu Peng 
Published: April 2024

AbstractOver the past few decades, the overuse of antibiotics has raised concerns about drinking water and potential health risks, especially the hydrochloride tetracycline (TC‐HCl). Therefore, it is crucial to develop a simple, low‐cost and high‐efficiency photocatalyst for the degradation of the pollutant. A novel photocatalyst with an S‐scheme heterojunction structure of AgIn5S8 and Bi2MoO6 was synthesized by using a solvothermal method. The heterojunction photocatalyst obtained demonstrates superior photocatalytic degradation activity for hydrochloride tetracycline (TC‐HCl) under visible light irradiation. It exhibits higher photocatalytic degradation performance than pure AgIn5S8 and Bi2MoO6 under the same conditions. The heterojunction with 3 % AgIn5S8 exhibited the highest degradation efficiency of 63.65 % within 40 minutes. Furthermore, the degradation rate is 6.21 times higher than that of AgIn5S8 and 2.18 times higher than that of Bi2MoO6. The improved photocatalytic activity is primarily attributed to the enhanced light absorption and the high rate of carrier separation resulting from S‐scheme heterojunctions.