bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic repair of ventral hernias with closure of the defect (IPOM+) in ambulatory surgery.
Authors: Licardie E , Bascuas B , Pineda Navarro N , Suárez Grau JM , Balongo García R 
Published: May 2024

Resumen

La reparación quirúrgica de hernias y eventraciones de línea media de la pared abdominal continúa siendo un reto para los cirujanos. A lo largo de los años se han descrito diversas técnicas de abordaje mínimamente invasivo con la finalidad de disminuir las tasas de recidiva y complicaciones. Actualmente, las guías recomiendan el abordaje mínimamente invasivo cuando las características del paciente sean favorables, y el cierre primario del defecto cuando sea posible. La tasa de recidiva de este tipo de intervenciones con abordaje laparoscópico oscila en torno a 7 - 8%. En nuestro artículo se describe la técnica quirúrgica para la reparación de una hernia ventral primaria asociada a diástasis de rectos con cierre primario del defecto y colocación de malla intraperitoneal y reducción de la fijación traumática, llevada a cabo en régimen de Cirugía Mayor Ambulatoria. Como conclusión, se recomienda individualizar cada caso y unificar los criterios quirúrgicos y anestésicos de pacientes con hernias ventrales que puedan ser candidatos a cirugía en régimen de CMA.
Glues as a method of mesh fixation in inguinal hernioplasty
Authors: Ruiz García BÁ , Aguilar del Castillo F , García Corona M , Almoguera González F , Suarez Grau JM , Tallón Aguilar L 
Published: May 2024

Resumen

Introducción:Existen distintos métodos de fijación de malla en la reparación de la hernia inguinal: traumáticos (sutura, tackers o grapas) y atraumáticos con mallas autoadhesivas o pegamentos (biológicos, semisintéticos, biosintéticos), siendo estos últimos el objetivo de nuestro estudio.

Resultados y discusión: La fijación traumática de la malla ha generado debate en la comunidad científica por el riesgo de dolor crónico y otras complicaciones, por lo que surgen nuevos métodos de fijación con el objetivo de disminuir dichas complicaciones siendo igual de efectivos en térmicos de recurrencia. En la literatura, encontramos numerosos estudios que comparan la fijación traumática con la fijación con pegamentos, determinando que la fijación con pegamento presenta menor tasa de dolor crónico a igual tasa de recidiva y de complicaciones postoperatorias, con menor tiempo quirúrgico y menor costo, siendo dicha evidencia no muy sólida hasta la fecha.

Conclusiones:La fijación de malla con pegamento presenta menor tasa de dolor crónico y menor tiempo quirúrgico, siendo igual de eficaz en términos de riesgo comparativo de recidiva, así como siendo más costo-efectiva. Si bien, todavía existe una falta de evidencia sólida para respaldar el uso rutinario de dicho tipo de fijación.
دراسة مقارنة نتائج قيمة العلو (Head) العملية بالنتائج الحسابية والبرمجية
Authors: احمد الزروق بارود د. فرج 
Published: May 2024

قمنا في هذه الدراسة بمقارنة النتائج التي تم الحصول عليها من التجربة باستخدام طريقة العنصر المحدد مع نتائج الحسابات التي تم الحصول عليها مسبقًا من برنامج Ansys CFX و كذلك مع نتائج التجارب العملية المعملية التي أجريناها في شركة (فنياين) المساهمة.
في حساباتنا اعتمادنا التدفق في الجزء الهيدروليكي من المضخة و اعتبرنا المائع غير قابل للا نضغاط , و التدفق مستقرغير متقطع ، وخالي من الدوامات ، وثلاثي الأبعاد ، واستندنا لحل المسألة ثلاثية الأبعاد على طريقة العنصر المحدود ، وقمنا بحساب متوسط ​​السرعة المحيطية ومتوسط ​​السرعة المطلقة عند مدخل ومخرج الدفاعة , و لحساب قيمة العلو (Head) المتوقع استخدمنا معادلة أويلر.
ان قيمة العلو (Head) المحسوبة باستخدام طريقة العنصر المحدد و نتائج التجربة العملية والنتائج التي تم الحصول عليها باستخدام البرنامج Ansys CFX تطابق مع نتائج العلو المتوقعة في منطقة التشغيل وإلى يمينها , و ان نتائج العلو (Head) تحدد لنا ما اذا المضخة بحاجة للتعديلات وعليه يتم تحسين الخصائص الهيدروديناميكية للمضخة
Peran Pemerintah Kotabumi Meningkatkan Perdagangan Internasional Khususnya Ekspor
Authors: Rumianti Susti , Mervita Eda , Iskandar Dadang Ishak 
Published: May 2024

International trade is the main pillar of the global economy, therefore the government's role is needed to improve the quality and quantity of international trade, especially exports, by implementing import duty exemption policies and providing incentives for MSMEs. The government must also be able to take advantage of the potential for market expansion and improve people's welfare. However, strict supervision of imports is also needed to protect domestic industry from the negative impacts of international trade. The government needs to use various instruments, such as tariffs and import quotas, to strike a balance between protecting local industry and meeting domestic needs. Free trade agreements are also an important instrument for opening wider market access. This research highlights the key role of government in managing the dynamics of international trade for sustainable economic growth and societal welfare.

Keywords : International Trade, Government, Export
DESIGN OF EMERGENCY EXITS IN BUILDINGS WITH ELLIPTICAL CORRIDORS. RESEARCH DESIGN
Authors: Голкин А.В. , Шамонин В.Г. , Зуев С.А. , Хатунцева С.Ю. 
Published: May 2024

Рассмотрена возможность решения задачи оптимального расположения эвакуационных выходов (ЭВ) в коридорах эллиптического типа при максимальной удаленности ЭВ друг от друга, минимизирующей смешение людских потоков (и, соответственно, паники) при эвакуации в случае пожара или других чрезвычайных ситуаций. Рассматривалось расположение ЭВ по обеим сторонам коридора, в торцах которого имеется хотя бы один ЭВ, ведущий на лестничную клетку или в безопасную зону. Предложена последовательность шагов для реализации поставленной задачи – нахождению оптимальной конфигурации заданного числа ЭВ на обеих сторонах коридора.
There was considered the possibility of solving the problem of emergency exits (EE) optimal location in elliptical corridors with the maximum distance of EEs from each other, minimizing the mixing of human flows (and, accordingly, panic) during evacuation in case of fire or other emergencies. There was examined the location of EE on both sides of the corridor, with at least one EE at the end of the corridor leading to a staircase or safe area. A sequence of steps was proposed to implement the task – to find the optimal configuration of a given number of EEs on both sides of the corridor.
Los pueblos indígenas en el escenario global: Una perspectiva desde las Relaciones Internacionales sobre los Derechos Humanos en México
Authors: Ulises Lescure José , Altagracia Hernández Basilia , Chang Monterrey Venicia 
Published: May 2024

Esta investigación explora el papel de las Relaciones Internacionales (RI) en la defensa y promoción de los derechos humanos de los pueblos indígenas en México. Utilizando una metodología cualitativa y un enfoque de investigación documental, el estudio propone que las RI, como disciplina, poseen herramientas únicas para influir en la política global y nacional de manera que se respeten y promuevan los derechos de estas comunidades. A través de teorías como el realismo, el idealismo y el constructivismo, se analiza cómo las interacciones internacionales pueden ser un vehículo para el empoderamiento de los pueblos indígenas. Se discute ampliamente el uso del “soft power” —herramientas no coercitivas como la cultura, los valores y las prácticas diplomáticas— como medio para mejorar la imagen y la posición de los pueblos indígenas en el escenario mundial. Este poder suave permite a las comunidades indígenas articular sus necesidades y derechos de manera efectiva, influenciando tanto a organismos internacionales como a opiniones públicas y gobiernos extranjeros. Además, el estudio pone un énfasis particular en el empoderamiento de la mujer indígena como eje central para la preservación cultural y la transmisión de valores y tradiciones de generación en generación. Se argumenta que el fortalecimiento de las mujeres indígenas no solo ayuda a proteger el tejido social y cultural de estas comunidades, sino que también contribuye a su estabilidad y progreso socioeconómico. Finalmente, el documento aborda cómo la interacción entre los derechos humanos universales y las especificidades culturales de los pueblos indígenas pueden coexistir y enriquecerse mutuamente a través de las RI. Los autores concluyen que, al incorporar las perspectivas de los pueblos indígenas en las negociaciones y diálogos internacionales, se pueden encontrar soluciones más inclusivas y efectivas a los desafíos globales contemporáneos.
Drug interaction detection and glycemic control – telepharmacy’s role in diabetes management: before-after study
Authors: Lisni Ida , Latarissa Irma Rahayu , Andalusia Lucia Rizka , Lestari Keri 
Published: May 2024

Introduction: Diabetes management faces intertwined challenges like polypharmacy and adherence complexities, hindering effective care delivery. Telepharmacy emerges as a promising solution, revolutionizing diabetes care by enhancing pharmacists’ pivotal role. However, a tailored model for Indonesia is still lacking.
Purpose: This study aimed to assess the potential effectiveness of a telepharmacy application in improving the detection of drug-drug interactions and glycemic control.
Methods: We conducted an observational before-and-after study among type 2 diabetic patients in Indonesia.
Results: We noted a significant surge in detected drug interactions. Patients counseled through telepharmacy had 3.653 times higher likelihood of achieving good glycemic control.
Conclusion: The study underscores the positive impact of telepharmacy on drug interaction detection and glycemic control among Indonesian diabetics.
L’histoire de l’Alsace, entre science et engagement
Authors: Vitoux Marie-Claire 
Published: May 2024

Le champ de l’histoire d’Alsace est devenu au début du XXIe siècle un champ de bataille entre historiens « régionalistes » et historiens qualifiés de jacobins. La communication explique l’émergence et la radicalisation récente du débat sur l’identité alsacienne dans un contexte marqué par l’accélération du déclin de la culture alsacienne et par la crise démocratique. Elle analyse l’émergence d’une conception essentialiste de la culture alsacienne confondue avec l’affirmation d’une identité régionale propre et l’oppose à l’analyse historienne qui insiste sur la construction dans le temps de cette culture et de cette identité. Enfin, la communication rappelle les conditions méthodologiques et déontologiques qui permettent de rendre compatibles la science historique et l’engagement citoyen.
Un landgraviat d’Alsace pour Bernhard de Saxe-Weimar ?
Authors: Muller Frank 
Published: May 2024

L’article se propose d’étudier une occasion peu connue d’une éventuelle unification de l’Alsace au cours de la guerre de Trente Ans par l’octroi d’un landgraviat d’Alsace à Bernhard de Saxe-Weimar dans les années 1635-1639. Le duc était à l’époque le meilleur chef de guerre du côté protestant et suédois, mais la France de Richelieu a essayé de se l’attacher en lui fournissant de l’argent et en lui promettant un landgraviat d’Alsace, dont les contours géo-politiques sont restés flous d’un côté comme de l’autre, le territoire de l’Alsace étant morcelé et régi par des souverains différents, en tenant compte aussi des villes libres. Par la prise de Breisach en 1638, un des buts de guerre était atteint, le duc voulant sans doute se constituer une principauté englobant principalement les anciens territoires de l’Autriche Antérieure de part et d’autre du Rhin et probablement d’autres territoires en Basse-Alsace. Mais sa mort en 1639 a fait que la majeure partie de l’Alsace est restée sous la « protection » de la France jusqu’aux traités de Westphalie.
Clinical feasibility of laparoscopic left lateral segment liver resection with magnetic anchor technique: The first clinical study from China
Authors: Zhang Miao-Miao , Bai Ji-Gang , Zhang Dong , Tao Jie , Geng Zhi-Min , Li Zhuo-Qun , Ren Yu-Xiang , Zhang Yu-Han , Lyu Yi , Yan Xiao-Peng 
Published: May 2024

BACKGROUND
Magnetic anchor technique (MAT) has been applied in laparoscopic cholecystectomy and laparoscopic appendectomy, but has not been reported in laparoscopic partial hepatectomy.
AIM
To evaluate the feasibility of the MAT in laparoscopic left lateral segment liver resection.
METHODS
Retrospective analysis was conducted on the clinical data of eight patients who underwent laparoscopic left lateral segment liver resection assisted by MAT in our department from July 2020 to November 2021. The Y-Z magnetic anchor devices (Y-Z MADs) was independently designed and developed by the author of this paper, which consists of the anchor magnet and magnetic grasping apparatus. Surgical time, intraoperative blood loss, intraoperative accidents, operator experience, postoperative incision pain score, postoperative complications, and other indicators were evaluated and analyzed.
RESULTS
All eight patients underwent a MAT-assisted laparoscopic left lateral segment liver resection, including three patients undertaking conventional 5-port and five patients having a transumbilical single-port operation. The mean operation time was 138 ± 34.32 min (range 95-185 min) and the mean intraoperative blood loss was 123 ± 88.60 mL (range 20-300 mL). No adverse events occurred during the operation. The Y-Z MADs showed good workability and maneuverability in both tissue and organ exposure. In particular, the operators did not experience either a “chopstick” or “sword-fight” effect in the single-port laparoscopic operation.
CONCLUSION
The results show that the MAT is safe and feasible for laparoscopic left lateral segment liver resection, especially, exhibits its unique abettance for transumbilical single-port laparoscopic left lateral segment liver resection.
Establishment of acquired tracheoesophageal fistula using a modified magnetic compression technique in rabbits and its postmodeling evaluation
Authors: Meng Han , Nan Fu-Yao , Kou Na , Hong Qin-Yan , Lv Ming-Sheng , Li Ju-Bo , Zhang Bao-Jie , Zou Hang , Li Lei , Wang Hong-Wu 
Published: May 2024

BACKGROUND
Previous studies have validated the efficacy of both magnetic compression and surgical techniques in creating rabbit tracheoesophageal fistula (TEF) models. Magnetic compression achieves a 100% success rate but requires more time, while surgery, though less frequently successful, offers rapid model establishment and technical maturity in larger animal models.
AIM
To determine the optimal approach for rabbit disease modeling and refine the process.
METHODS
TEF models were created in 12 rabbits using both the modified magnetic compression technique and surgery. Comparisons of the time to model establishment, success rate, food and water intake, weight changes, activity levels, bronchoscopy findings, white blood cell counts, and biopsies were performed. In response to the failures encountered during modified magnetic compression modeling, we increased the sample size to 15 rabbit models and assessed the repeatability and stability of the models, comparing them with the original magnetic compression technique.
RESULTS
The modified magnetic compression technique achieved a 66.7% success rate, whereas the success rate of the surgery technique was 33.3%. Surviving surgical rabbits might not meet subsequent experimental requirements due to TEF-related inflammation. In the modified magnetic compression group, one rabbit died, possibly due to magnet corrosion, and another died from tracheal magnet obstruction. Similar events occurred during the second round of modified magnetic compression modeling, with one rabbit possibly succumbing to aggravated lung infection. The operation time of the first round of modified magnetic compression was 3.2 ± 0.6 min, which was significantly reduced to 2.1 ± 0.4 min in the second round, compared to both the first round and that of the original technique.
CONCLUSION
The modified magnetic compression technique exhibits lower stress responses, a simple procedure, a high success rate, and lower modeling costs, making it a more appropriate choice for constructing TEF models in rabbits.
Metastatic stomach lymphoepithelioma-like carcinoma and immune checkpoint inhibitor therapy: A case report
Authors: Chen Guo-Feng , Wang Jun , Yan Yu , Xu Song , Chen Jian 
Published: May 2024

BACKGROUND
Pulmonary lymphoepithelioma-like carcinoma (PLELC) is a rare type of non-small-cell lung cancer. Stomach lymphoepithelioma-like carcinoma (LELC) metastasis secondary to PLELC has not been reported recently.
CASE SUMMARY
A 64-year-old female was admitted to our hospital for a regular gastroscopy examination with a 6-year history of surgical resection for left PLELC. Positron emission tomography/computed tomography suggested high accumulation of 18F-fludeoxyglucose in the gastric cardia region. Upper gastrointestinal endoscopy confirmed a large mass at the stomach fundus. Immunohistochemistry (IHC) of the biopsy suggested metastatic stomach LELC. Proximal gastrectomy showed that this 6.5 cm × 5.0 cm mass was located in the stomach fundus near the cardia. Histopathological examination showed a poorly differentiated carcinoma with prominent lymphoplasmacytic infiltration. IHC demonstrated that the tumor was positive for CK (AE1/AE3), p63, p40, p53, Ki-67 (70%), and EGFR (3+) and negative for CK7, CK20, Her2, and CD10. In situ hybridization analysis showed positive staining Epstein-Barr virus-encoded RNA. Tumor programmed cell death ligand 1 (PD-L1) expression score was 98%, and the combined positive score was 100, with no evidence of microsatellite instability. Thus, the patient was unequivocally diagnosed with metastatic stomach LELC secondary to pulmonary LELC. After discharge, this patient underwent PD-1 inhibitor treatment (toripalimab, 240 mg) every 3 wk for ten cycles, and she has had no tumor recurrence.
CONCLUSION
For gastric LELC metastasis, PD-1 inhibitor therapy could become a new therapeutic approach, though there is still no evidence from large data sets to support this.
Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma: A case report and review of literature
Authors: Chen Fei , Li Wei-Wei , Mo Juan-Fen , Chen Min-Jie , Wang Su-Hang , Yang Shu-Ying , Song Zheng-Wei 
Published: May 2024

BACKGROUND
Neuroendocrine carcinoma (NEC) of the extrahepatic bile duct is very rare, and the treatment and prognosis are unclear. Herein, we report the case of a middle-aged female with primary large cell NEC (LCNEC) of the common hepatic duct combined with distal cholangiocarcinoma (dCCA). Additionally, after a review of the relevant literature, we summarize and compare mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN) and pure NEC to provide a reference for selecting the appropriate treatment and predicting the prognosis of this rare disease.
CASE SUMMARY
A 62-year-old female presented to the hospital due to recurrent abdominal pain for 2 months. Physical examination showed mild tenderness in the upper abdomen and a positive Courvoisier sign. Blood tests showed elevated liver transaminase and carbohydrate antigen 199 levels. Imaging examination revealed a 1-cm tumour in the middle and lower segments of the common bile duct. Pancreaticoduodenectomy + lymph node dissection was performed, and hepatic duct tumours were unexpectedly found during surgery. Pathology suggested poorly differentiated LCNEC (approximately 0.5 cm × 0.5 cm × 0.4 cm), Ki-67 (50%), synaptophysin+, and chromogranin A+. dCCA pathology suggested moderately differentiated adenocarcinoma. The patient eventually developed lymph node metastasis in the liver, bone, peritoneum, and abdominal cavity and died 24 months after surgery. Gene sequencing methods were used to compare gene mutations in the two primary bile duct tumours.
CONCLUSION
The prognosis of MiNEN and pure NEC alone is different, and the selection of treatment options needs to be differentiated.
Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis
Authors: Zhang Shuai , Lu Chuan , Zheng Sheng , Hong Guang 
Published: May 2024

BACKGROUND
Bone healing is a complex process involving early inflammatory immune regulation, angiogenesis, osteogenic differentiation, and biomineralization. Fracture repair poses challenges for orthopedic surgeons, necessitating the search for efficient healing methods.
AIM
To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells (BMSCs) facilitate the process of fracture healing.
METHODS
Hydrogels and loaded BMSC-derived exosome (BMSC-exo) gels were characterized to validate their properties. In vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing process. Hydrogels could recruit macrophages and inhibit inflammatory responses, enhance of human umbilical vein endothelial cell angiogenesis, and promote the osteogenic differentiation of primary cranial osteoblasts. Furthermore, the effect of hydrogel on fracture healing was confirmed using a mouse fracture model.
RESULTS
The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration, promoted the formation of large vessels, and enabled functional vascularization during bone repair. These effects were further validated in fracture models.
CONCLUSION
We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.
The Coloniality of Global Health and Africa’s Epistemic Dependence on The West in the Covid-19 era: Need for Decolonization of Knowledge
Authors: Marcel Jachin Anyiam 
Published: May 2024

The coloniality of global health and its corresponding impact on the future of Africa has become a subject of intense debate among researchers and scholars alike. Africa’s epistemic dependence on the West during outbreak of any pandemic, especially in the Covid-19 era clearly describes the place of Africa in the global health politics. This study therefore examines the dangers associated with Africa’s acceptance of epistemic rejection by the West. The study poses the following questions: Does the coloniality of the global health by the West account for the Africa’s inefficiency in providing solutions to global health challenges?. To what extent does the epistemic dependence of Africa on the West inhibit African researchers from providing solutions to the global pandemics such as Covid-19? The methodology adopted in this study is the qualitative method. Findings of the study shows that there is a strong relationship between Africa’s epistemic dependence on the West and the Africa’s predicament in the face of any global pandemic as well as other global health challenges. The study recommends inter alia that if Africa is to be relevant in the global health politics, Africans must put up a nonviolent and intellectual struggle until decolonization of knowleedge is achieved.