bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase III, Randomized, Double-Blind, Placebo-Controlled Evaluation of Pregabalin for Alleviating Hot Flashes, N07C1
Authors: Loprinzi Charles L. , Qin Rui , Baclueva Ernie P. , Flynn Kathleen A. , Rowland Kendrith M. , Graham David L. , Erwin Nancy K. , Dakhil Shaker R. , Jurgens Donald J. , Burger Kelli N. 
Published: November 2009

Purpose Hot flashes are a common problem for which effective and safe treatments are needed. The current trial was conducted on the basis of preliminary promising data that pregabalin decreased hot flashes. Patients and Methods A double-blind, placebo-controlled, randomized trial design was used to compare pregabalin at target doses of 75 mg twice daily and 150 mg twice daily with a placebo. Hot flash frequencies and scores (frequency times mean severity) were recorded daily during a baseline week and for six treatment weeks. The primary end point for this study was the change-from-baseline hot flash score during treatment week 6 between the 150 mg twice daily target pregabalin treatment and placebo. Nonparametric Wilcoxon rank sum tests, two-sample t tests, and χ2 tests were used to compare the primary and secondary hot flash efficacy end points between pregabalin treatments and placebo. Results Hot flash score changes available for 163 patients during the sixth treatment week compared with a baseline week decreased by 50%, 65%, and 71% in the placebo, and target 75 mg twice daily and 150 mg twice daily pregabalin arms, respectively (P = .009 and P = .007, comparing respective pregabalin arms to the placebo arm). While some toxicities were significantly more common in the pregabalin arms, being more evident with the higher dose, pregabalin was generally well tolerated by most patients. Conclusion Pregabalin decreases hot flashes and is reasonably well tolerated. A target dose of 75 mg twice daily is recommended. Its effects appear to be roughly comparable to what has been reported with gabapentin and with some newer antidepressants.
Photoinduced Hydrogen-Evolution System with an Antibody–Porphyrin Complex as a Photosensitizer
Authors: Yamaguchi Hiroyasu , Onji Takeshi , Ohara Hidetaka , Ikeda Noriaki , Harada Akira 
Published: November 2009

Abstract
A complex between a monoclonal antibody for porphyrin and zinc–porphyrin was utilized to construct an energy conversion system. Monoclonal antibody 2B6 bound meso-tetrakis(4-carboxyphenyl)porphyrin zinc complex (ZnTCPP) with a dissociation constant of 2.1 × 10−8 M. Upon binding the antibody, the lifetime of the excited triplet state of ZnTCPP increased from 0.5 to 1.2 ms. A stable cationic radical of viologen was obtained by irradiating the solution containing the complex of 2B6 with ZnTCPP, methyl viologen (MV2+), and ethylenediaminetetraacetic acid tetrasodium salt (EDTA-4Na) with light. When colloidal platinum was added as a catalyst, photoinduced hydrogen production was observed upon continuous irradiation of visible light. The estimated turnover number of photoinduced hydrogen evolution was 5.0 × 10−3 s−1. The catalytic activity of the 2B6–ZnTCPP complex on the hydrogen evolution was compared with that of ZnTCPP alone and the complexes of ZnTCPP with fragments of antibody 2B6 (2B6-H and 2B6-L). The heavy chain of antibody 2B6 mainly contributed to the complex formation with ZnTCPP and the resultant hydrogen production, and the whole antibody–ZnTCPP complex led to the efficient hydrogen production.
Crystal structure determination of N,N′-1,4-phenylene-bis(3-oxobutanamide) from laboratory powder diffraction data
Authors: Brüning Jürgen , Alig Edith , Bats Jan W. , van de Streek Jacco , Schmidt Martin U. 
Published: November 2009

Abstract
The compound N,N′-1,4-phenylene-bis(3-oxobutanamide) is an industrial intermediate used in the synthesis of azo pigments.
Crystallisation experiments only led to the dihydrate form; drying the dihydrate at 120 °C leads to an anhydrous form, but suitable single crystals of the anhydrous form could not be grown. Therefore, its crystal structure was determined from laboratory powder diffraction data. The structure was solved by real-space methods using the program DASH and refined by the Rietveld method using the program TOPAS. The anhydrous form crystallises in P21/c, Z = 2 with lattice parameters a = 16.9749(5) Å, b = 4.8648(1) Å, c = 8.5372(2) Å, β = 93.396(2)°. The crystal structure of the dihydrate was determined by single-crystal structure analysis. The dihydrate crystallises in P – 1, Z = 1 with a = 5.0116(1) Å, b = 5.2199(2) Å, c = 14.7803(5) Å, α = 88.396(1)°, β = 80.250(1)°, γ = 81.439(1)°. In both crystal structures the molecule, which has a centre of symmetry, is situated on an inversion centre. For the anhydrous form dispersion-corrected DFT calculations were used to confirm the structure.
Natural History of Spinal Anomalies and Scoliosis Associated With Esophageal Atresia
Authors: Sistonen Saara J. , Helenius Ilkka , Peltonen Jari , Sarna Seppo , Rintala Risto J. , Pakarinen Mikko P. 
Published: November 2009

OBJECTIVE: Clinical characteristics of spinal deformities that commonly occur in patients with esophageal atresia (EA) are unclear. The objective of this study was to assess the incidence and natural history of spinal anomalies and scoliosis in patients with EA.
METHODS: A population-based cohort of 100 adults who had an operation for EA in our hospital were examined clinically and radiographically for spinal deformities. The results were compared with data obtained from normal population-based controls.
RESULTS: Vertebral anomalies were observed in 45 patients, predominating in the cervical spine in 38 patients. Any additional anomaly was the most significant risk factor (odds ratio [OR]: 27 [95% confidence interval (CI): 8–100]) for the occurrence of vertebral anomalies. Scoliosis of &gt;10° was observed in 56 patients, &gt;20° in 11 patients, and &gt;45° in 1 patient. The risk for scoliosis of &gt;10° was 13-fold (OR: 13 [95% CI: 8.3–21]), and the risk for scoliosis of &gt;20° was 38-fold (OR: 38 [95% CI: 14–106]) compared with those in the normal population. Thoracotomy-induced rib fusions (OR: 3.6 [95% CI: 0.7–19]) and other associated anomalies (OR: 2.1 [95% CI: 0.9–2.9]) were the strongest predictive factors for scoliosis. The general clinical course of spinal deformities was mild, and none of the patients had undergone spinal surgery.
CONCLUSIONS: The risk of scoliosis is 13-fold after repair of EA in relation to general population. Nearly half of the patients have vertebral anomalies predominating in the cervical spine. Most of these deformities were not diagnosed primarily or during growth. Spinal surgery is rarely indicated.
HIV Risk Reduction Among Detained Adolescents: A Randomized, Controlled Trial
Authors: Bryan Angela D. , Schmiege Sarah J. , Broaddus Michelle R. 
Published: November 2009

OBJECTIVES: Criminally involved adolescents engage in high levels of alcohol-related risky sex. A theory-based sexual and alcohol risk-reduction intervention was designed, implemented, and evaluated in juvenile detention facilities.Participants and Methods. In a randomized, controlled trial, 484 detained adolescents received 1 of 3 group-based interventions: combined sexual and alcohol risk reduction (group psychosocial intervention [GPI] + group motivational enhancement therapy [GMET]); sexual risk reduction only (GPI); or HIV/sexually transmitted disease prevention information only (group information-only intervention [GINFO]). Follow-up data were obtained 3, 6, 9, and 12 months after the intervention. Behavioral outcomes were condom-use behavior, frequency of intercourse while drinking, and alcohol-related problems.RESULTS: Condom-use behavior measured as frequency of condom use during sex (ranging from never to always) decreased over time, although the GPI and GPI + GMET interventions mitigated this tendency at the 3-, 6-, and 9-month follow-up assessments. Although both active interventions were significantly more successful than the GINFO condition and the pattern of effects favored the GPI + GMET, there were no statistically significant differences between the GPI and GPI + GMET interventions.CONCLUSIONS: Findings support the feasibility of integrating alcohol-specific sexual risk content into a theory-based sexual risk-reduction intervention and provide additional evidence that theory-based interventions are effective at reducing risky sex in this population. There was limited evidence of intervention effects on alcohol-use outcomes. Future research should focus on strengthening the GPI + GMET to most effectively target risky sexual behavior among at-risk adolescents.
Bone Regeneration and Periosteoplasty: A 250-Year-Long History
Authors: Lazzeri Davide , Gatti Gian Luca , Romeo Gianfranco , Balmelli Bruno , Massei Alessandro 
Published: November 2009

Background: Since antiquity, many attempts have been carried out and a number of theories proposed to explain the process that leads to bone regeneration. Through manifold experiments, several authors tried to understand and subsequently to control the physiological events that enable bone healing. Between the 18th and 19th centuries something changed. Although the scientific world was initially skeptical, a new idea emerged in the field of bone surgery. It principally concerned the necessity to perform amputations and resections leaving intact the periosteum to obtain new bone formation. Materials and Methods: With this article we emphasize the contribution of many authors in the development of knowledge about the osteogenic properties of the periosteum. In particular we focus on the experiences of unknown Italian authors Michele Troja and Bernardino Larghi, consider well-recognized scientific personalities such as Leopold Ollier and Bernhard von Langenbeck, and reach a milestone of plastic surgery with Tord Skoog and his description of periosteoplasty. Conclusion: Various surgical approaches have been proposed to provide optimal care for patients with cleft lip and palate disorders. Among several treatment options, periosteoplasty is one of the choices to correct maxillary clefts. Highlighting difficulties and successes of many authors in demonstrating osteogenic properties of periosteum, this paper describes how periosteoplasty performed in maxillary cleft restoration capitalizes on what has been discovered during a 250-year-long history.
Longitudinal Study of Growth of Children with Unilateral Cleft-Lip Palate from Birth to Two Years of Age
Authors: Marques Ilza L. , Nackashi John A. , Borgo Hilton C. , Martinelli Ângela P. M. C. , Pegoraro-Krook Maria I. , Williams William N. , Dutka Jeniffer C. R. , Seagle Michael B. , Souza Telma V. , Garla Luis A. , Neto José S. M. , Silva Marcos L. N. , Graciano Maria I. G. , Moorhead Jacquelyn , Piazentin-Penna Sílvia H. A. , Feniman Mariza R. , Zimmermann Maria C. , Bento-Gonçalves Cristina G. A. , Pimentel Maria C. M. , Boggs Steve , Jorge José C. , Antonelli Patrick J. , Shuster Jonathan 
Published: November 2009

Objective: To study the growth of children with complete unilateral cleft lip and palate (UCLP) from birth to 2 years of age and to construct specific UCLP growth curves. Design: Physical growth was a secondary outcome measure of a National Institutes of Health–sponsored longitudinal, prospective clinical trial involving the University of Florida (United States) and the University of São Paulo (Brazil). Patients: Six hundred twenty-seven children with UCLP, nonsyndromic, both genders. Methods: Length, weight, and head circumference were prospectively measured for a group of children enrolled in a clinical trial. Median growth curves for the three parameters (length, weight, head circumference) were performed and compared with the median for the National Center for Health Statistics (NCHS) curves. The median values for length, weight, and head circumference at birth and 6, 12, 18, and 24 months of age were plotted against NCHS median values and statistically compared at birth and 24 months. Setting: Hospital de Reabilitação de Anomalias Craniofaciais, Universidade de São Paulo, Bauru, Brazil (HRAC-USP). Results: At birth, children of both genders with UCLP presented with smaller body dimensions in relation to NCHS median values, but the results suggest a catch-up growth for length, weight, and head circumference for girls and for weight (to some degree) and head circumference for boys. Conclusions: Weight was the most compromised parameter for both genders, followed by length and then head circumference. There was no evidence of short stature. This study established growth curves for children with UCLP.
Secondary Alveolar Bone Grafting: Outcomes, Revisions, and New Applications
Authors: Goudy Steven , Lott David , Burton Richard , Wheeler Jim , Canady John 
Published: November 2009

Introduction: Cleft lip and palate deformities are one of the most common birth defects. The alveolar cleft requires bony repair to allow proper eruption of dentition. The purpose of this study is to evaluate success in the repair of alveolar clefts and examine whether the addition of allogenic materials improves outcomes. Materials and Methods: One hundred three patients with cleft lip and palate were identified retrospectively after institutional review board approval was obtained. The authors reviewed their medical records, surgical complication rate, need for revision surgery, and whether allogenic materials were used. The data were then compared using analysis of variance. Results: The average patient age was 16.6 years (range, 7 to 25 years). There were 59% unilateral clefts and 41% bilateral clefts identified. The average age at palate repair was 17.5 months. The average age at alveolar bone grafting (ABG) was 8.9 years (range, 5 to 15 years). Allogenic material was used in 22 primary ABGs and 10 revision ABGs. The revision rate of unilateral ABGs was 18%, which was statistically different from the 32% revision rate of bilateral ABGs. The use of allogenic material during ABG repair did not affect the revision rate. Conclusion: Secondary alveolar bone grafting is necessary for complete rehabilitation of the cleft alveolus. The patients undergoing ABG had an overall 23% revision rate, 18% for unilateral and 32% for bilateral clefts. The use of allogenic materials during ABG did not show a statistical benefit in this study, but future review including more patients may be useful.
Apples and Oranges—Midface Hypoplasia and the Le Fort I Osteotomy in Cleft Lip and Palate Patients: A Classification Scheme and Treatment Protocol
Authors: Felemovicius Jacobo , Taylor Jesse A. 
Published: November 2009

Objective: To present a classification and treatment protocol for cleft lip and palate patients with midface hypoplasia. Design: Retrospective case series. Setting: Craniofacial center. Patients: The study included 133 patients with cleft lip and palate and maxillary hypoplasia treated with Le Fort I osteotomy between January 2000 and July 2006. Interventions: Modified Le Fort I osteotomy. Patients were divided into three groups based on the number of free-standing bony maxillary segments, and treatment was tailored to their deformity. Main Outcome Measures: Complications and long-term relapse rates. Results: The 133 patients underwent 142 operations with mean follow-up of 27 months. Mean horizontal advancement was 7.1 ± 1.9 mm, 6.5 ± 1.3 mm, 6.4 ± 1.6 mm, and 6.5 ± 1.3 mm for groups I, II, IIIA, and IIIB, respectively. Complications consisted of nine bony relapses, three hematomas, and two transitory neurosensory losses. Analysis of variance using number of maxillary pieces as the independent variable and millimeters of advancement as the dependent variable demonstrated no difference in the amounts that the groups were advanced (p  =  .23). Relapse rates for groups I, II, IIIA, and IIIB were 2/62 (3.2%), 5/53 (9.4%), 2/14 (14.3%), and 0/4 (0.0%), respectively. Analysis of variance did not demonstrate a statistical difference in relapse rates based on number of maxillary pieces. Conclusions: Cleft lip and palate patients can be classified into three groups based on the number of maxillary segments. Our classification system defines the differences among this diverse group of patients and also facilitates unique treatment of each group.
Approximate D-optimal designs of experiments on the convex hull of a finite set of information matrices
Authors: Harman Radoslav , Trnovská Mária 
Published: November 2009

Abstract
In the paper we solve the problem of D
ℋ-optimal design on a discrete experimental domain, which is formally equivalent to maximizing determinant on the convex hull of a finite set of positive semidefinite matrices. The problem of D
ℋ-optimality covers many special design settings, e.g., the D-optimal experimental design for multivariate regression models. For D
ℋ-optimal designs we prove several theorems generalizing known properties of standard D-optimality. Moreover, we show that D
ℋ-optimal designs can be numerically computed using a multiplicative algorithm, for which we give a proof of convergence. We illustrate the results on the problem of D-optimal augmentation of independent regression trials for the quadratic model on a rectangular grid of points in the plane.
FACTORS AFFECTING CATCH IN PHEROMONE TRAPS FOR MONITORING THE WESTERN SPRUCE BUDWORM, CHORISTONEURA OCCIDENTALIS FREEMAN
Authors: Sweeney J.D. , McLean J.A. , Shepherd R.F. 
Published: November 2009

AbstractThe effects of trap design, lure concentration, lure age, and trap maintenance on the catch of western spruce budworm moths, Choristoneura occidentalis Freeman, in pheromone traps were tested in light to moderate infestations near Ashcroft, B.C. High cumulative moth catches reduced the trapping efficiency of both the sticky traps and the non-sticky Uni-traps relative to traps from which the moths were removed every 2 days. Correlations between the total season’s catch and larval density per plot in the same and following generations were not significant (P>0.05) for any of the eight combinations of trap design, lure concentration, and maintenance regimen tested. However, by dividing the mean moth catch in Uni-traps by either the basal area or foliage biomass per hectare in each plot, correlations with the following year’s larval density were significant (r2 = 0.77–0.98; P<0.05; n=5).
HOST UTILIZATION BY COLORADO POTATO BEETLE (COLEOPTERA: CHRYSOMELIDAE) IN A POTATO/WEED (SOLANUM SARRACHOIDES SENDT.) SYSTEM
Authors: Horton David R. , Capinera John L. 
Published: November 2009

AbstractA non-pest population of Colorado potato beetle, Leptinotarsa decemlineata (Say), was monitored in the field and in the laboratory to define some cultural and host plant factors that might prompt increased use of potato by a population locally adapted to a wild host species (Solanum sarrachoides Sendt.). This study tested whether elimination of the beetle’s natural host from plots of potato would result in increased densities of beetles on potato, and examined whether beetles showed differences in performance on and in preference for S. sarrachoides or potato. In 2 years of study, egg densities on potato were higher in weed-free than weedy plots; paired preference tests in the laboratory also indicated that beetles deposited the most egg masses (92%) on S. sarrachoides. Densities of larvae and adults on potato were not affected by weed density. Growth rates of larvae were significantly faster on S. sarrachoides than on potato for both early-season (pre 7 July) and late-season (post 21 July) foliage. Survival and adult size were not affected by host species. In choice tests, late-instar larvae preferred S. sarrachoides to potato. Host preference of larvae varied with age of foliage, and S. sarrachoides became increasingly preferred later in the growing season.
CYTOTAXONOMY OF CONOPHTHORUS (COLEOPTERA: SCOLYTIDAE) IN EASTERN NORTH AMERICA
Authors: de Groot Peter , Ennis Terry J. 
Published: November 2009

AbstractThe male meiotic karyotypic formula of Conophthorus coniperda (Schwarz) (Coleoptera: Scolytidae) is 9AA + XY. This karyotype differs from C. resinosae Hopkins and C. banksianae McPherson, both of which have the karyotypic formula of 8AA + XY. Supernumerary chromosomes were found in different populations of C. resinosae and C. banksianae but were absent in C. coniperda. No geographic variation in the karyotypes of the three species was observed. The karyotypic formulae confirm the designations of C. coniperda and C. resinosae by morphological characters, but do not support the designation of C. banksianae as a distinct species.
ALLOMETRY IN THE LAST LARVAL INSTARS OF SIMULIUM TRUNCATUM (LUNDSTRÖM) AND S. ROSTRATUM (LUNDSTRÖM) (DIPTERA: SIMULIIDAE)
Authors: McCreadie John W. , Colbo Murray H. 
Published: November 2009

AbstractData from larval head capsule measurements are used to determine allometry of size for final-instar siblings Simulium truncatum (Lundström) (= EFG/C) and S. rostratum (Lundström) (= ACD) of the S. venustum/verecundum complex (Diptera: Simuliidae). Measurements were evaluated using principal axis and major reduced axis regression. Isometry of size was accepted for only some ratios and it is argued that a character’s “environmental stability” should be assessed before it is considered as a taxonomic character.
DESCRIPTION AND LIFE HISTORY OF THE PREDATORY BUG PODISUS SAGITTA (FAB.) (HEMIPTERA: PENTATOMIDAE)
Authors: Clercq P. De , Degheele D. 
Published: November 2009

AbstractPodisus sagitta (Fab.) is a small- to medium-sized predatory stink bug, which is distributed from the southern United States into South America. The immature stages and both sexes of the adult insect from a laboratory strain are described and illustrated. Notes on the life history of P. sagitta also are given.
EFFECTS OF SUB-LETHAL EXPOSURES TO MALATHION OR CHLORPYRIFOS-METHYL ON OFFSPRING PRODUCTION BY SOME STORED-PRODUCT BEETLES
Authors: White N.D.G. , Sinha R.N. 
Published: November 2009

AbstractExposure of adult rusty grain beetles, Cryptolestes ferrugineus (Stephens), saw-toothed grain beetles, Oryzaephilus surinamensis (L.), and red flour beetles, Tribolium castaneum (Herbst), to filter papers treated with the organophosphorus insecticides malathion or chlorpyrifos-methyl often affected offspring production in survivors. Groups of five male and five female survivors were placed on ground wheat at 30°C and C. ferrugineus and O. surinamensis adults produced fewer offspring with prolonged exposure to chlorpyrifos-methyl; malathion had no effect. Tribolium castaneum adults produced significantly more offspring with increasing exposure to both malathion and chlorpyrifos-methyl indicating stimulation of oviposition or a selection for increased fitness in survivors.