bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cocaine use in sinonasal surgery: patients’ perspective on its use and the need for pre-operative consent
Authors: Yeo Justin Jui Yuan , Badrol Sharifah Sara Syed , Maan Amandeep , Chan Jacquline , Barraclough James , Jervis Suzanne 
Published: May 2024

AbstractObjectivesIntranasal cocaine is commonly used in endoscopic sinus surgery due to its vasoconstrictive and anaesthetic properties. This study aimed to understand patients’ perspectives and whether patients should have to give their consent for its use.MethodsProspective data were collected over a three-month period in ENT departments in the out-patient setting of two district general hospitals. An anonymous questionnaire was distributed to all adult patients asking for their thoughts on cocaine use in sinonasal surgery and the need for peri-operative discussion.ResultsIn total, 123 patient questionnaires were analysed. It was found that 9.8 per cent of patients knew of cocaine use in sinonasal surgery, 73.2 per cent of patients stated they would like a pre-operative discussion on cocaine use before surgery and 83.1 per cent of patients raised concerns over cocaine's illicit status, mainly its effect on work and driving. Only 34 per cent of patients said that they would prefer an alternative to cocaine.ConclusionThis study found that patients want to know if and when cocaine is being used intra-operatively without necessarily objecting to it.
High-throughput sequencing of Strongyloides stercoralis – a fatal disseminated infection in a dog
Authors: Nosková Eva , Svobodová Vlasta , Hypská Vilma , Cerezo-Echevarria Argiñe , Kurucová Terézia , Ilík Vladislav , Modrý David , Pafčo Barbora 
Published: May 2024

AbstractThe rhabditid nematode Strongyloides stercoralis is known worldwide as the causative agent of strongyloidiasis in humans. In addition to public health concerns, S. stercoralis also infects dogs, which represent a possible reservoir for potentially zoonotic transmissions. We describe the first confirmed case of fatal disseminated infection in a dog in the Czech Republic. The microscopic and histological results were supported by a complex genotyping approach. Using high-throughput sequencing of the hypervariable region (HVR-IV) of 18S rDNA and Sanger sequencing of the partial cytochrome c oxidase subunit 1 gene (cox1), the potentially zoonotic haplotype/lineage A of S. stercoralis was confirmed, while the solely canine haplotype/lineage B was not found. The development of the disease is mainly associated with immunodeficiency, and in this case, it was triggered by inappropriate treatment, in particular the use of corticosteroids.
Foreign language learning boredom: Refining its measurement and determining its role in language learning
Authors: Li Chengchen , Feng Enhao , Zhao Xian , Dewaele Jean-Marc 
Published: May 2024

AbstractThis cross-sectional and longitudinal study sought to refine the measurement of foreign language learning boredom (FLLB) and examine its links with overall/skill-specific second and foreign language (L2) achievement (curriculum-based course exam scores) and proficiency (Cambridge English test scores). In Substudy 1, we developed and validated an 11-itemForeign Language Learning Boredom Scale–Short Formamong secondary and tertiary English as a foreign language (EFL) learners in China (n1= 2,223,n2= 504,n3= 934,n4= 1,109). The scale showed sound psychometric properties (i.e., construct/criterion/convergent/discriminant/predictive validity, reliability, and measurement invariance across time and groups). In Substudy 2, structural equation modeling results show that FLLB had a consistent modest negative effect on overall and skill-specific (vocabulary and grammar, listening, reading, and writing) L2 achievement and proficiency (n4= 1,109). Substudy 3 was a 12-month three-semester longitudinal investigation (n4= 1,109). Cross-lagged panel modeling results show that L2 achievement predicted subsequent FLLB negatively, while FLLB did not predict subsequent L2 achievement.
On planarity of graphs in homotopy type theory
Authors: Prieto-Cubides Jonathan , Gylterud Håkon Robbestad 
Published: May 2024

AbstractIn this paper, we present a constructive and proof-relevant development of graph theory, including the notion of maps, their faces and maps of graphs embedded in the sphere, in homotopy type theory (HoTT). This allows us to provide an elementary characterisation of planarity for locally directed finite and connected multigraphs that takes inspiration from topological graph theory, particularly from combinatorial embeddings of graphs into surfaces. A graph is planar if it has a map and an outer face with which any walk in the embedded graph is walk-homotopic to another. A result is that this type of planar maps forms a homotopy set for a graph. As a way to construct examples of planar graphs inductively, extensions of planar maps are introduced. We formalise the essential parts of this work in the proof assistant Agda with support for HoTT.
Germination attributes of metsulfuron-resistant and metsulfuron-susceptible tropical ageratum (Ageratum conyzoides) populations under various environmental conditions
Authors: Desai Devanshi Het , Desai Het Samir , Chauhan Bhagirath Singh 
Published: May 2024

AbstractTropical ageratum (Ageratum conyzoides L.) is a problematic weed frequently observed in association with commercially important crops in Australian agroecosystems. Knowledge of the germination response of A. conyzoides is crucial for proactively managing this weed species, especially when herbicide resistance is involved. Herbicide screening and metsulfuron dose–response experiments were conducted on two separate populations of A. conyzoides (referred to as Sugarcane and Roadside) in an open environment to identify a metsulfuron-resistant population. Based on the survival percentage in the metsulfuron dose–response experiment, the Sugarcane population was found to be 54 times more resistant compared with the metsulfuron-susceptible population (Roadside). Subsequent laboratory experiments were performed to investigate the differential germination response of the two populations. No germination or emergence difference was observed between the Sugarcane and Roadside populations under various thermal regimes (15/5 to 35/25 C with a 12/12-h photoperiod), salinity levels (0 to 320 mM), osmotic potentials (0 to −1.6 MPa), and burial depths (1 to 4 cm). However, different environmental conditions significantly impacted the germination and emergence of A. conyzoides. Ageratum conyzoides germinated over a wide range of temperatures, with the highest germination rate (>90%) occurring at 30/20 C. With increasing levels of salinity, osmotic potential, and burial depth, the germination/emergence of A. conyzoides declined and was completely inhibited at 300 mM salinity, −0.8 MPa osmotic potential, and a 1-cm burial depth. The data generated from this study will be useful in developing a model-based approach to predict the occurrence of this weed species and thus aid in designing ecologically sustainable integrated weed management protocols.
Geographical, Seasonal and Diurnal Variations of Acoustic Attenuation, and Sound Speed in the Near‐Surface Martian Atmosphere
Authors: Gillier Martin , Petculescu Andi , Murdoch Naomi , Stott Alexander E. , Gerier Solène , Maurice Sylvestre , Mimoun David 
Published: May 2024

AbstractThis work introduces a comprehensive model of sound attenuation and speed on Mars, in light of the recent operation of several microphones on the surface of Mars. The proposed acoustic model calculates the sound speed and attenuation throughout the near‐surface Martian atmosphere based on first‐principles. We evaluate the effects of the seasonal and diurnal cycle of air temperature, pressure and CO2, as well as the concentration of airborne dust on the sound attenuation. The attenuation and speed of sound are most sensitive to the air temperature and, therefore, they vary with the diurnal temperature cycle and to a lesser degree with the seasonal changes in temperature. The speed of sound also varies with the seasonal variations of the concentration of CO2. The main outcome of this work is an acoustic model capable of computing the sound speed and attenuation for any location at the Martian surface at any time of year and any time of day.
Reproducibility of Equatorial Kelvin Waves in a Superparameterized MIROC: 1. Implementation and Verification of Blockwise‐Coupled SP‐MIROC
Authors: Yamazaki K. , Miura H. 
Published: May 2024

AbstractThe potential scope of superparameterization (SP) was extended to higher resolutions of the global climate model (GCM) component by devising a technique called blockwise coupling. In this method, a horizontal average of multiple GCM columns, instead of one, is coupled to a cloud‐resolving model (CRM) domain. This enables SP‐GCMs to reduce the computational cost drastically, enabling higher‐resolution GCMs to be superparameterized. A blockwise‐coupled SP‐GCM called SP‐MIROC was implemented by coupling the climate model MIROC6 to the CRM SCALE‐RM. The 4 × 4‐bundled SP‐MIROC successfully reproduced horizontal patterns and frequency distributions of precipitation and realistic amplitudes of equatorial Kelvin waves (EKWs), which were underestimated in the standard MIROC6. As discussed in Yamazaki and Miura (2024b, https://doi.org/10.1029/2023MS003837) of this study, the amplitude boost of EKWs was enabled by a top‐heavy heating in SP‐MIROC. Comparison of power spectra between the 4 × 4‐bundled SP‐MIROC and nonbundled SP‐MIROC indicated that the effective resolution of dynamic variables was not degraded by the blockwise technique. Rather, spectra in the 4 × 4‐bundled SP‐MIROC were more realistic than those in the nonbundled SP‐MIROC. Although the 4 × 4‐bundling limits convective coupling in the smallest GCM scale, it could offer the best match of resolutions between the GCM‐handled dynamics and SP‐derived physics because the effective resolution of the dynamics is lower than the nominal grid spacing.
Tropical Warming and Intensification of the West African Monsoon During the Miocene Climatic Optimum
Authors: Wubben Evi , Spiering Bianca R. , Veenstra Tjerk , Bos Remco , Wang Zongyi , van Dijk Joost , Raffi Isabella , Witkowski Jakub , Hilgen Frederik J. , Peterse Francien , Sangiorgi Francesca , Sluijs Appy 
Published: May 2024

AbstractStudying monsoon dynamics during past warm time periods such as the Miocene Climatic Optimum (MCO; ∼16.9–14.5 Ma) could greatly aid in better projecting monsoon intensity, in the context of future greenhouse warming. However, studies on regional MCO temperature change and its effect on the monsoons during this time period are lacking. Here, we present the first high‐resolution, low‐latitude record of sea surface temperature (SST) and paleoceanographic change covering the Miocene Climatic Optimum, in the eastern equatorial Atlantic, at Ocean Drilling Program Site 959, based on TEX86 paleothermometry. SSTs were ∼1.5°C warmer at the onset of the MCO (16.9 Ma) relative to the pre‐MCO (∼18.3–17.7 Ma). This warming was accompanied by a transient increase in %total organic carbon. Prior to the MCO, sediment composition, geochemical proxy data as well as dinoflagellate cyst assemblages imply a productive surface ocean at Site 959. Immediately following the MCO onset (∼16.9–16.5 Ma), we record an intensification of the West African Monsoon (WAM) characterized by higher amplitude variability in all proxy records on precession to obliquity timescales. We interpret increased orbital‐scale SST, biogenic Ba and dinocyst assemblage variability to represent intensification of equatorial upwelling, forced by the WAM strength. Furthermore, higher SSTs during eccentricity maxima correlate to increased relative abundances of the warm and stratification‐favoring dinocyst Polysphaeridium zoharyi, during periods of low WAM intensity. Finally, while long‐term SSTs decline toward the middle Miocene, maximum SSTs and Polysphaeridium zoharyi abundances occur during MCO peak warming at ∼15.6 Ma.
Early to Middle Miocene Astronomically Paced Climate Dynamics in the Eastern Equatorial Atlantic
Authors: Spiering Bianca R. , Wubben Evi , Hilgen Frederik J. , Sluijs Appy 
Published: May 2024

AbstractDetailed analysis of tropical climate dynamics is lacking for the Early to Middle Miocene, even though this time interval bears important analogies for future climates. Based on high‐resolution proxy reconstructions of sea surface temperature, export productivity and dust supply at Ocean Drilling Program Site 959, we investigate astronomical forcing of the West African monsoon in the eastern equatorial Atlantic across the prelude, onset, and continuation of the Miocene Climatic Optimum (MCO; 18–15 Ma). Along with previously identified eccentricity periodicities of ∼400 and ∼100 kyr, our records show that climate varied on ∼27–17 kyr, ∼41 kyr, and ∼60–50 kyr timescales, which we attribute to precession, obliquity, and their combination tones, respectively. The relative contribution of these astronomical cycles differed between proxies and through time. Three intervals with distinct variability were recognized, which are particularly clear in the temperature record: (a) strong eccentricity, obliquity, and precession variability prior to the MCO (18.2–17.7 Ma), (b) strong influence of obliquity just after the onset of the MCO (16.9–16.3 Ma) concurring with a 2.4 Myr eccentricity minimum, and (c) dominant eccentricity and precession variability during the MCO between 16.3 and 15.0 Ma. Sedimentation at Site 959 was influenced by astronomically paced variations in upwelling intensity and North African aridity related to West African monsoon dynamics. Continuously present patterns of precession imply low‐latitude forcing, while asymmetric eccentricity and obliquity imprints and strong obliquity influence suggest that Site 959 was also affected by high‐latitude, glacial‐interglacial dynamics.
Magnetic Response to the Source‐To‐Sink Environmental Changes in the Bay of Bengal Since ∼60 ka
Authors: Guan Yulong , Jiang Zhaoxia , Li Sanzhong , Chen Liang , Liu Yang , Chen Yuying , Zhang Yuzhen , Chen Long , Zhou Liang , Yin Zhengxin 
Published: May 2024

AbstractThe terrestrial magnetic minerals of marine sediments are utilized to track the climatic changes in the source area and the dynamic characteristics of sedimentation processes. However, due to the varied source‐to‐sink environments, the magnetic response to ambient climate cannot be generalized. Here, we conducted systematic environmental magnetic analyses on core CJ04‐50 from the Ninetyeast Ridge and investigated its magnetic response to source‐to‐sink environmental changes. Core CJ04‐50 covers the last 60 Kyr based on accelerator mass spectrometry (AMS) 14C dating and the relative paleointensity (RPI) record. Rare earth element (REE) results suggest that the terrestrial materials are fed by the Ganges‐Brahmaputra (G‐B) and Irrawaddy/Indo‐Burma Ranges. High/low magnetic mineral content corresponds to strong/weak terristrial input during the cold/warm period. This pattern differs from that in the East Asian marginal seas, which have a high magnetic mineral content in warm periods. It might be attributed to the heavier Indian summer monsoon (ISM) precipitation than that of East Asian summer monsoon. Excessive moisture (>1,500 mm/year) would not favor the formation and preservation of magnetic minerals in the source area during interglacials. By contrast, the enhanced physical weathering during glacials results in more magnetic contributions. A significant local magnetite dissolution occurred at the layer of Middle MIS 3, which may be caused by the non‐steady state diagenesis following deposition.
Unique lipid composition maintained by extracellular blockade leads to prooncogenicity
Authors: Kudo Kai , Yanagiya Ryo , Hasegawa Masanori , Carreras Joaquim , Miki Yoshimi , Nakayama Shunya , Nagashima Etsuko , Miyatake Yuji , Torii Kan , Ando Kiyoshi , Nakamura Naoya , Miyajima Akira , Murakami Makoto , Kotani Ai 
Published: May 2024

AbstractLipid-mediated inflammation is involved in the development and malignancy of cancer. We previously demonstrated the existence of a novel oncogenic mechanism utilizing membrane lipids of extracellular vesicles in Epstein–Barr virus (EBV)-positive lymphomas and found that the lipid composition of lymphoma cells is skewed toward ω-3 fatty acids, which are anti-inflammatory lipids, suggesting an alteration in systemic lipid composition. The results showed that arachidonic acid (AA), an inflammatory lipid, was significantly reduced in the infected cells but detected at high levels in the sera of EBV-positive patients lead to the finding of the blockade of extracellular AA influx by downregulating FATP2, a long-chain fatty acid transporter that mainly transports AA in EBV-infected lymphoma cells. Low AA levels in tumor cells induced by downregulation of FATP2 expression confer resistance to ferroptosis and support tumor growth. TCGA data analysis and xenograft models have demonstrated that the axis plays a critical role in several types of cancers, especially poor prognostic cancers, such as glioblastoma and melanoma. Overall, our in vitro, in vivo, in silico, and clinical data suggest that several cancers exert oncogenic activity by maintaining their special lipid composition via extracellular blockade.
New liposidomycin congeners produced by Streptomyces sp. TMPU-20A065, anti-Mycobacterium avium complex agents with therapeutic efficacy in a silkworm infection model
Authors: Yagi Akiho , Fujiwara Mayu , Sato Mayu , Abe Yuzu , Uchida Ryuji 
Published: May 2024

AbstractThree new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5–17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposidomycins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 1, 2, and 4 belong to type-I liposidomycin-containing sulfate groups and methylglutaric acid, each with a different acyl side chain in the structure. Compounds 1–17 exhibited in vitro anti-M. avium and M. intracellulare activities with MIC values ranging between 2.0 and 64 μg ml−1. Furthermore, 1–17 exerted potent therapeutic effects in an in vivo-mimic silkworm infection model with ED50 values ranging between 0.12 and 3.7 μg larva−1 g−1.
“On-Water” accelerated dearomative cycloaddition via aquaphotocatalysis
Authors: Kim Soo Bok , Kim Dong Hyeon , Bae Han Yong 
Published: May 2024

AbstractSulfur(VI) fluoride exchange (SuFEx) has emerged as an innovative click chemistry to harness the pivotal connectivity of sulfonyl fluorides. Synthesizing such alkylated S(VI) molecules through a straightforward process is of paramount importance, and their water-compatibility opens the door to a plethora of applications in biorelevant and materials chemistry. Prior aquatic endeavors have primarily focused on delivering catalysts involving ionic mechanisms, studies regarding visible-light photocatalytic transformation are unprecedented. Herein we report an on-water accelerated dearomative aquaphotocatalysis for heterocyclic alkyl SuFEx hubs. Notably, water exerts a pronounced accelerating effect on the [2 + 2] cycloaddition between (hetero)arylated ethenesulfonyl fluorides and inert heteroaromatics. This phenomenon is likely due to the high-pressure-like reactivity amplification at the water-oil interface. Conventional solvents proved totally ineffective, leading to the isomerization of the starting material.
Tracing fossil-based plastics, chemicals and fertilizers production in China
Authors: Jiang Meng , Cao Yuheng , Liu Changgong , Chen Dingjiang , Zhou Wenji , Wen Qian , Yu Hejiang , Jiang Jian , Ren Yucheng , Hu Shanying , Hertwich Edgar , Zhu Bing 
Published: May 2024

AbstractPhasing down fossil fuels is crucial for climate mitigation. Even though 80–90% of fossil fuels are used to provide energy, their use as feedstock to produce plastics, fertilizers, and chemicals, is associated with substantial CO2 emissions. However, our understanding of hard-to-abate chemical production remains limited. Here we developed a chemical process-based material flow model to investigate the non-energy use of fossil fuels and CO2 emissions in China. Results show in 2017, the chemical industry used 0.18 Gt of coal, 88.8 Mt of crude oil, and 12.9 Mt of natural gas as feedstock, constituting 5%, 15%, and 7% of China’s respective total use. Coal-fed production of methanol, ammonia, and PVCs contributes to 0.27 Gt CO2 emissions ( ~ 3% of China’s emissions). As China seeks to balance high CO2 emissions of coal-fed production with import dependence on oil and gas, improving energy efficiency and coupling green hydrogen emerges as attractive alternatives for decarbonization.
High yield electrosynthesis of oxygenates from CO using a relay Cu-Ag co-catalyst system
Authors: Meng Nannan , Wu Zhitan , Huang Yanmei , Zhang Jie , Chen Maoxin , Ma Haibin , Li Hongjiao , Xi Shibo , Lin Ming , Wu Wenya , Han Shuhe , Yu Yifu , Yang Quan-Hong , Zhang Bin , Loh Kian Ping 
Published: May 2024

AbstractAs a sustainable alternative to fossil fuel-based manufacture of bulk oxygenates, electrochemical synthesis using CO and H2O as raw materials at ambient conditions offers immense appeal. However, the upscaling of the electrosynthesis of oxygenates encounters kinetic bottlenecks arising from the competing hydrogen evolution reaction with the selective production of ethylene. Herein, a catalytic relay system that can perform in tandem CO capture, activation, intermediate transfer and enrichment on a Cu-Ag composite catalyst is used for attaining high yield CO-to-oxygenates electrosynthesis at high current densities. The composite catalyst Cu/30Ag (molar ratio of Cu to Ag is 7:3) enables high efficiency CO-to-oxygenates conversion, attaining a maximum partial current density for oxygenates of 800 mA cm−2 at an applied current density of 1200 mA cm−2, and with 67 % selectivity. The ability to finely control the production of ethylene and oxygenates highlights the principle of efficient catalyst design based on the relay mechanism.
Semantic regularization of electromagnetic inverse problems
Authors: Zhang Hongrui , Chen Yanjin , Wang Zhuo , Cui Tie Jun , del Hougne Philipp , Li Lianlin 
Published: May 2024

AbstractSolving ill-posed inverse problems typically requires regularization based on prior knowledge. To date, only prior knowledge that is formulated mathematically (e.g., sparsity of the unknown) or implicitly learned from quantitative data can be used for regularization. Thereby, semantically formulated prior knowledge derived from human reasoning and recognition is excluded. Here, we introduce and demonstrate the concept of semantic regularization based on a pre-trained large language model to overcome this vexing limitation. We study the approach, first, numerically in a prototypical 2D inverse scattering problem, and, second, experimentally in 3D and 4D compressive microwave imaging problems based on programmable metasurfaces. We highlight that semantic regularization enables new forms of highly-sought privacy protection for applications like smart homes, touchless human-machine interaction and security screening: selected subjects in the scene can be concealed, or their actions and postures can be altered in the reconstruction by manipulating the semantic prior with suitable language-based control commands.