bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Photophysical Properties of LnIII–DOTA–Bipy Complexes and LnIII–DOTA–Bipy–RuII Coordination Conjugates
Authors: Vázquez López Miguel , Eliseeva Svetlana V. , Blanco José M. , Rama Gustavo , Bermejo Manuel R. , Vázquez M. Eugenio , Bünzli Jean‐Claude G. 
Published: August 2010

AbstractThe synthesis and the systematic and comparative photophysical study of a series of visible (EuIII, TbIII) and NIR‐emitting (NdIII, YbIII) lanthanide complexes (Ln2L) and ruthenium–lanthanide coordination conjugates (Ln2LRu) are reported. The GdIII complex, the GdIII–RuII coordination conjugate, as well as the RuII complex of the ligand H6L have also been synthesized and photophysically studied as control systems. The ligand H6L, composed of a central bipyridine binding unit and functionalized on each 5′‐position with a DOTA macrocycle, has been successfully synthesized from cyclen, 5,5′‐dimethyl‐2,2′‐bipyridine and 1,2‐ethylendiamine in a nine‐step process. Detailed luminescence studies of all complexes, including the determination of the quantum yield and lifetime, were carried out on finely powdered microcrystalline samples as well as in water, deuterated water and [D6]DMSO at ambient (295 K) and low temperature (77 K). The photophysical data corroborate the existence of energy transfer in the Ln2L complexes and in the Nd2LRu coordination conjugate. However, no (or at most, very little) energy transfer is takes place from the Ru(bipy)3 chromophore to the LnIII ion in the other Ln2LRu heteropolymetallic complexes. Moreover, the photophysical studies reveal that all the complexes and coordination conjugates adopt different conformations and hydration states in solution and in the solid state, which influences the efficiency of the energy transfer between the bipy and/or Ru(bipy)3 antennae and the LnIII ions.
Sequential Sonogashira/Carbopalladative Cyclization/Suzuki Reactions Catalyzed by a Single Palladium Source by Using Protected Homopropargyl Alcohol
Authors: Wang Xin , Liu Lingyan , Chang Weixing , Li Jing 
Published: August 2010

AbstractA novel cascade combination reaction catalyzed by a single palladium source for the synthesis of various indene derivatives is reported. The approach involved sequential Sonogashira/carbopalladative cyclization/Suzuki coupling reactions by using three readily available components, such as homopropargyl alcohol, aryl iodides or aryl bromides, and arylboronic acids. The overall domino reaction yields were up to 70 %.
Synthesis of Pyridodiazepinediones by Using the Ugi Multicomponent Reaction
Authors: Van den Bogaert An M. , Nelissen Jo , Ovaere Margriet , Van Meervelt Luc , Compernolle Frans , De Borggraeve Wim M. 
Published: August 2010

AbstractBenzodiazepines show a broad spectrum of biological activities. In an ongoing effort to extend molecular diversity in this type of systems, we developed a strategy for synthesizing3,4‐dihydro‐1H‐pyrido[2,3‐e][1,4]diazepine‐2,5‐dione compounds starting from 2‐hydroxynicotinic acid and by using an Ugi reaction as a key step in the synthesis. We opted to use 2‐isocyanophenyl benzoate instead of Armstrong's convertible isocyanide in this multicomponent reaction.
Streamlined Access to Functionalized Chromenes and Quinolines using Domino Reactions of Salicylic Aldehydes and Methyl 4‐Chloro‐2‐butynoate
Authors: Bello Davide , Ruiz‐Rodríguez Javier , Albericio Fernando , Ramón Rosario , Lavilla Rodolfo 
Published: August 2010

AbstractMethyl 4‐chloro‐2‐butynoate was used in a modified Morita–Baylis–Hillman reaction with salicylic aldehydes. The chlorine atom in the alkynoate moiety allows its efficient isomerization to the corresponding allene, and remains in the adduct as a reactive site. Further one‐pot derivatization leads to a variety of substituted chromenes and quinolines.
Total Synthesis of Tyrosine‐Derived Tetramic Acid Pigments from a Slime Mould
Authors: Riache Nassima , Bailly Christine , Deville Alexandre , Dubost Lionel , Nay Bastien 
Published: August 2010

AbstractA method for the total synthesis of naturally occurring 3‐enoyltetramic acids derived from L‐tyrosine is described, allowing for three chemical transformations to occur in one pot by using a multicomponent mixture. The sequence involves (1) a base‐promoted Lacey–Dieckmann condensation, (2) a Michaelis–Becker reaction, and (3) a Wittig–Horner–Emmons reaction between the resulting 3‐phosphonoacetyltetramic acid and an appropriate aldehyde. This sequence of reactions was applied to the synthesis of polyenic pigments obtained from the slime mould Leocarpus fragilis starting from readily available precursors. A series of structurally related compounds was also synthesized and their antibiotic significance was evaluated to elucidate their role in nature.
Zn/C‐Catalyzed Cycloaddition of Azides and Aryl Alkynes
Authors: Meng Xu , Xu Xiaoyun , Gao Tingting , Chen Baohua 
Published: August 2010

AbstractCharcoal impregnated with zinc was able to catalyze the cycloaddition of organic azides and alkynes to provide the corresponding 1,4‐disubstituted 1,2,3‐triazoles and 1,4,5‐trisubstituted 1,2,3‐triazoles in good to excellent yields. Noteworthy was that the novel and heterogeneous catalyst was successfully applied in this cycloaddition reaction for the first time and could also be easily recycled.
C(sp3)–C(sp3) Bond Breaking in Methylenecyclopropanes Involving a AuI/AuIII Catalytic Cycle
Authors: Zhang Di‐Han , Dai Lun‐Zhi , Shi Min 
Published: August 2010

AbstractGold(I) can catalyze the diacetoxylation of methylenecyclopropanes to produce the corresponding diacetoxylated products in moderate to good yields in acetic acid in the presence of iodosobenzene diacetate via C–C bond breaking under mild condition.
Highly Enantioselective Addition of 1‐Fluoro‐1‐nitro(phenylsulfonyl)methane to α,β‐Unsaturated Aldehydes
Authors: Kamlar Martin , Bravo Natalia , Alba Andrea‐Nekane R. , Hybelbauerová Simona , Císařová Ivana , Veselý Jan , Moyano Albert , Rios Ramon 
Published: August 2010

AbstractAn organocatalytic, highly enantioselective addition of 1‐fluoro‐1‐nitro(phenylsulfonyl)methane to α,β‐unsaturated aldehydes is reported. The reaction is simply catalyzed by secondary amines and furnishes the corresponding fluorinated derivatives in good yields, with moderate diastereoselectivities and excellent enantioselectivities. The absolute configuration of the major diastereomers was unambiguously ascertained by X‐ray diffraction analysis.
Cooperative and Enantioselective NbCl5/Primary Amine Catalyzed Biginelli Reaction
Authors: Cai Yong‐Feng , Yang Hua‐Meng , Li Li , Jiang Ke‐Zhi , Lai Guo‐Qiao , Jiang Jian‐Xiong , Xu Li‐Wen 
Published: August 2010

AbstractA series of chiral organocatalysts and Lewis acids have been evaluated in the Lewis acid/organocatalysts‐based cooperative catalytic Biginelli reaction, which resulted in the determination of a novel cooperative Lewis acid/primary amine catalyst system, NbCl5/QN‐NH2. The synergistic effect of NbCl5 and the quinine‐derived primary amine is pronounced and gave dihydropyrimidiones (DHPMs) in moderate to good enantioselectivities (up to 84 % ee) and good to excellent yields (up to 99 % yield) under mild conditions.
Characterization of the Nucleophilic Allylindium Species Generated from Allyl Bromide and Indium(0) in Aqueous Media
Authors: Yasuda Makoto , Haga Masahiko , Nagaoka Yasunori , Baba Akio 
Published: August 2010

AbstractThe reductive system of allyl bromide and indium(0) in water generated monoallylindium(III) dibromide and diallylindium(III) bromide. These compounds were characterized by X‐ray analysis after complexation with 3,5‐dibromopyridine or 4‐(dimethylamino)pyridine, respectively. Both isolated complexes showed high nucleophilicity and reacted with benzaldehyde to give the allylation product. The diallylindium(III) bromide was less stable in water than the monoallylindium(III) dibromide. The reaction of the diallylindium(III) with benzhydrol gave a (μ‐alkoxido)indium species that showed nucleophilicity. This result suggests that allyl(μ‐hydroxido)indium also acted as a nucleophile in an aqueous Barbie‐type reaction system.
Electrophoretic mapping of highly homologous keratins: A novel marker peptide approach
Authors: Deb‐Choudhury Santanu , Plowman Jeffrey E. , Thomas Ancy , Krsinic Gail L. , Dyer Jolon M. , Clerens Stefan 
Published: August 2010

AbstractIdentification of the intermediate filament proteins (IFPs) in the wool proteome has formerly been hampered by limited sequence information, the high degree of IFP homology and their close proximity on 2‐DE maps. This has been partially rectified by the recent acquisition of four new Type I and two Type II wool IFP sequences. Among closely migrating proteins, such as IFP clusters in a 2‐DE map, proteins with higher sequence coverage will be assigned higher scores, but the identification of unique peptides in such tight clusters may distinguish these closely migrating proteins. Two approaches were adopted for the study of wool IFPs. In the first, searches were conducted for peptides known to be unique to each member of the family in each spot. In the second, MALDI imaging was employed to examine peptides bound to a PVDF membrane from a poorly resolved part of the Type I IFP region of the 2‐DE map. As a result, a distinct picture has emerged of the distribution of the six Type I and four Type II IFPs across the 2‐DE wool protein map.
Electrokinetic supercharging focusing in capillary zone electrophoresis of weakly ionizable analytes in environmental and biological samples
Authors: Botello Igor , Borrull Francesc , Aguilar Carme , Calull Marta 
Published: August 2010

AbstractFive non‐steroidal anti‐inflammatory drugs, naproxen, fenoprofen, ketoprofen, diclofenac and piroxicam, were separated and analyzed by electrokinetic supercharging in CZE. Three different setups of the ITP technique were assayed for the separation and preconcentration of these five non‐steroidal anti‐inflammatory drugs. For the setup that gave the best results, we evaluated the influence of different parameters on separation and preconcentration efficiency such as sample pH, concentration of the leading stacker, BGE composition, electrokinetic injection time, composition and hydrodynamic injection of the solvent plug and of the terminating stacker. In the selected setup, the BGE (10 mM Na2B4O7 + 50 mM NaCl in 10% of MeOH aqueous solution) contained the leading electrolyte while the terminating electrolyte, hydrodynamically injected after the sample (50 mbar×12 s), was 50 mM of CHES. Prior to sample injection at (700 s at −2 kV) a short plug of MeOH (50 mbar ×3 s) was hydrodynamically injected. The results show that this strategy enhanced detection sensitivity 2000‐fold compared with normal hydrodynamic injection, providing detection limits of 0.08 μg/L for standard samples with good repeatability (values of relative standard deviation, %RSD < 1.03%). Method validation with river water samples and human plasma demonstrated good linearity, with detection limits of 0.9 and 2 μg/L for river water samples and human plasma samples, respectively (as well as satisfactory precision in terms of repeatability and reproducibility).
Sulfoalkylbetaine‐based monolithic column with mixed‐mode of hydrophilic interaction and strong anion‐exchange stationary phase for capillary electrochromatography
Authors: Wang Xiaochun , Ding Kang , Yang Chunmei , Lin Xucong , Lü Haixia , Wu Xiaoping , Xie Zenghong 
Published: August 2010

AbstractA novel monolithic stationary phase with mixed mode of hydrophilic and strong anion exchange (SAX) interactions based on in situ copolymerization of pentaerythritol triacrylate (PETA), N,N‐dimethyl‐N‐methacryloxyethyl N‐(3‐sulfopropyl) ammonium betaine (DMMSA) and a selected quaternary amine acrylic monomer was designed as a multifunctional separation column for CEC. Although the zwitterionic functionalities of DMMSA and hydroxy groups of PETA on the surface of the monolithic stationary phase functioned as the hydrophilic interaction (HI) sites, the quaternary amine acrylic monomer was introduced to control the magnitude of the EOF and provide the SAX sites at the same time. Three different quaternary amine acrylic monomers were tested to achieve maximum EOF velocity and highest plate count. The fabrication of the zwitterionic monolith (designated as HI and SAX stationary phase) was carried out when [2‐(acryloyloxy)ethyl]trimethylammonium methylsulfate was used as the quaternary amine acrylic monomer. The separation mechanism of the monolithic column was discussed in detail. For charged analytes, a mixed mode of HI and SAX was observed by studying the influence of mobile phase pH and salt concentration on their retentions on the poly(PETA‐co‐DMMSA‐co‐[2‐(acryloyloxy)ethyl]trimethylammonium methylsulfate) monolithic column. The optimized monolith showed good separation performance for a range of polar analytes including nucleotides, nucleic acid bases and nucleosides, phenols, estrogens and small peptides. The column efficiencies greater than 192 000 theoretical plates/m for estriol and 135 000 theoretical plates/m for charged cytidine were obtained.
One‐step production of biocommodities from lignocellulosic biomass by recombinant cellulolytic Bacillus subtilis: Opportunities and challenges
Authors: Zhang Xiao‐Zhou , Zhang Yi‐Heng P. 
Published: August 2010

AbstractOne‐step consolidated bioprocessing that integrates cellulase production, cellulose hydrolysis, and product fermentation into a single step for decreasing costly cellulase use, increasing volumetric productivity, and reducing capital investment is widely accepted for low‐cost production of biofuels or other value‐added biochemicals. Considering the narrow margins between biomass and low‐value biocommodities, good physiological performance of industrial microbes is crucial for economically viable production. Bacillus subtilis, the best‐characterized Gram‐positive microorganism, is a major industrial microorganism with numerous valuable features such as hexose and pentose utilization, low‐nutrient needs, fast growth rate, high protein secretion capacity, industrial safety, etc. As compared with other potential consolidated bioprocessing microorganisms such as Clostridium spp., Escherichia coli, and the yeast Saccharomyces cerevisiae, recombinant cellulolytic B. subtilis strains would be a potential platform for biocommodity production from nonfood biomass. Here, we review the advances in recombinant cellulolytic B. subtilis development and metabolic engineering for biocommodity production, and discuss the opportunities and challenges of cellulolytic B. subtilis for biocommodity production.
Annexin A1 attenuates EMT and metastatic potential in breast cancer
Authors: Maschler Sabine , Gebeshuber Christoph A. , Wiedemann Eva‐Maria , Alacakaptan Memetcan , Schreiber Martin , Custic Ivana , Beug Hartmut 
Published: August 2010

AbstractMetastasis is the major cause of carcinoma‐induced death, but mechanisms involved are poorly understood. Metastasis crucially involves epithelial‐to‐mesenchymal transition (EMT), causing loss of epithelial polarity. Here we identify Annexin A1 (AnxA1), a protein with important functions in intracellular vesicle trafficking, as an efficient suppressor of EMT and metastasis in breast cancer. AnxA1 levels were strongly reduced in EMT of mammary epithelial cells, in metastatic murine and human cell lines and in metastatic mouse and human carcinomas. RNAi‐mediated AnxA1 knockdown cooperated with oncogenic Ras to induce TGFβ‐independent EMT and metastasis in non‐metastatic cells. Strikingly, forced AnxA1 expression in metastatic mouse and human mammary carcinoma cells reversed EMT and abolished metastasis. AnxA1 knockdown stimulated multiple signalling pathways but only Tyk2/Stat3 and Erk1/2 signalling were essential for EMT.
Cellular model for sand dunes with saltation, avalanche and strong erosion: collisional simulation of barchans
Authors: Katsuki Atsunari , Kikuchi Macoto , Nishimori Hiraku , Endo Noritaka , Taniguchi Keisuke 
Published: August 2010

AbstractBarchans are crescent‐shaped dunes that form under unidirectional wind in areas of limited sand supply. The recent development of flume experiments and computer simulations has renewed interest in the interaction dynamics of two or more barchans. From the flume experiment, four distinguishable types of collision patterns between two barchans have been observed: coalescence, ejection, split and reorganization. We have proposed a simple cellular model for numerical simulations of dune dynamics, in which saltation and avalanche are elementary processes. In the present paper, we first describe the model in detail. The model reproduces three types of collision patterns: coalescence, ejection, and reorganization. The largest reason for a split pattern not to occur is the lack of an effect of the flow separation at the brink line of dunes and the recirculation bubble that it produces. We then model the effect of the recirculation bubble by assuming that strong erosion occurs at the reattachment point of the separation flow. The strong‐erosion model successfully reproduces all the collision patterns. Thus, three elementary processes – saltation, avalanche and strong‐erosion – are sufficient for a phenomenological description of the interaction dynamics of aqueous barchans. It is also shown that the type of collision is determined by competition between the filling‐up of the interdune between two barchans and the change in height of each dune. Copyright © 2010 John Wiley & Sons, Ltd.
Ein Beitrag zur Kenntnis der anatolischen Flora. I
Authors: Huber‐Morath A. 
Published: August 2010

AbstractL'auteur rassemle les résultats floristiques des voyages de Reese, Wall, Renz, Skřivánek, Tengwall et Huber entrepris en Anatolie en 1935–1939. Cette première publication traite des Renoncluacées aux Rutacées en suivant l'ordre de Boissier, Flora Orientalis. Les espèces nouvelles pour l'Anatolie sont les suivantes: Barbaraea longirostris var. subglabra, Erophila minima, Silene apetala, Reaumuria hypericoides et Lavatera cretica. L'auteur remet en question l'endémisme corse de l'Alyssum corsicum Duby. Il a trouvé très abondamment cette espèce (déterminée par Nyárády!) en Anatolie (Carie), et suppose que la Corse n'est qu'une localité secondaire où la plante a été introduite depuis très longemps.
Die Bedeutung der Wuchsform für die Entwicklung des natürlichen Systems der Pflanzen
Authors: Meusel Hermann 
Published: August 2010

AbstractDas natürliche Pflanzensystem würde einer viel schärferen Begründung fähig sein, wenn es gelänge, vegetative Organe,. durch veränderte Methoden der Beobachtung besser zu unterscheiden. (GRISEBACH).
Emotion triggers executive attention: Anterior cingulate cortex and amygdala responses to emotional words in a conflict task
Authors: Kanske Philipp , Kotz Sonja A. 
Published: August 2010

AbstractCoherent behavior depends on attentional control that detects and resolves conflict between opposing actions. The current functional magnetic resonance imaging study tested the hypothesis that emotion triggers attentional control to speed up conflict processing in particularly salient situations. Therefore, we presented emotionally negative and neutral words in a version of the flanker task. In response to conflict, we found activation of the dorsal anterior cingulate cortex (ACC) and of the amygdala for emotional stimuli. When emotion and conflict coincided, a region in the ventral ACC was activated, which resulted in faster conflict processing in reaction times. Emotion also increased functional connectivity between the ventral ACC and activation of the dorsal ACC and the amygdala in conflict trials. These data suggest that the ventral ACC integrates emotion and conflict and prioritizes the processing of conflict in emotional trials. This adaptive mechanism ensures rapid detection and resolution of conflict in potentially threatening situations signaled by emotional stimuli. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Increased expression and serum levels of the stromal cell‐secreted protein periostin in breast cancer bone metastases
Authors: Contié Sylvain , Voorzanger‐Rousselot Nathalie , Litvin Judith , Clézardin Philippe , Garnero Patrick 
Published: August 2010

AbstractPeriostin, a matricellular protein, is overexpressed in the stroma of several cancers. The aim of our study was to investigate more specifically whether periostin expression is associated with bone metastases from breast cancer and to determine its source in the affected bone. Nude mice were inoculated with human MDA‐B02 breast cancer cells. Bone metastases‐bearing mice were treated with zoledronic acid—an antiresorptive drug—or vehicle. Bone metastases were examined for tumor‐ and stroma‐derived periostin expression by quantitative polymerase chain reaction with human‐ and mouse‐specific primers and immunohistochemistry. Serum periostin and conventional bone turnover markers were also measured. MDA‐B02 cells did not express periostin both in vitro and in vivo. However, mouse‐derived periostin was markedly overexpressed (eightfold) in metastatic legs compared to noninoculated mice. Serum periostin levels were also markedly increased in metastatic mice and correlated with in situ expression levels. Immunostaining showed that periostin derived from the environing stromal cells of bone metastasis. Bone turnover blockade by zoledronic acid markedly decreased osteolytic lesions but only slightly modulated serum periostin levels. Bone metastases from breast cancer induce overexpression of periostin by surrounding stromal cells. Periostin could be a biochemical marker of the early stromal response associated to breast cancer bone metastasis formation.
Birth order and risk of childhood cancer: A pooled analysis from five US States
Authors: Von Behren Julie , Spector Logan G. , Mueller Beth A. , Carozza Susan E. , Chow Eric J. , Fox Erin E. , Horel Scott , Johnson Kimberly J. , McLaughlin Colleen , Puumala Susan E. , Ross Julie A. , Reynolds Peggy 
Published: August 2010

AbstractThe causes of childhood cancers are largely unknown. Birth order has been used as a proxy for prenatal and postnatal exposures, such as frequency of infections and in utero hormone exposures. We investigated the association between birth order and childhood cancers in a pooled case‐control dataset. The subjects were drawn from population‐based registries of cancers and births in California, Minnesota, New York, Texas and Washington. We included 17,672 cases <15 years of age who were diagnosed from 1980 to 2004 and 57,966 randomly selected controls born 1970–2004, excluding children with Down syndrome. We calculated odds ratios and 95% confidence intervals using logistic regression, adjusted for sex, birth year, maternal race, maternal age, multiple birth, gestational age and birth weight. Overall, we found an inverse relationship between childhood cancer risk and birth order. For children in the fourth or higher birth order category compared to first‐born children, the adjusted OR was 0.87 (95% CI: 0.81, 0.93) for all cancers combined. When we examined risks by cancer type, a decreasing risk with increasing birth order was seen in the central nervous system tumors, neuroblastoma, bilateral retinoblastoma, Wilms tumor and rhabdomyosarcoma. We observed increased risks with increasing birth order for acute myeloid leukemia but a slight decrease in risk for acute lymphoid leukemia. These risk estimates were based on a very large sample size, which allowed us to examine rare cancer types with greater statistical power than in most previous studies, however the biologic mechanisms remain to be elucidated.