bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: The Role of Stereoactive Lone Pairs in Templated Vanadium Tellurite Charge Density Matching.
Authors: Chang Kelvin B. , Hubbard Desmond J. , Zeller Matthias , Schrier Joshua , Norquist Alexander J. 
Published: July 2010

AbstractThe crystal structure of the new compound (II) is determined by single crystal XRD (triclinic, space group P$\bar 1$, Z = 1).
ChemInform Abstract: A New Hexanuclear Iron—Selenium Nitrosyl Cluster: Primary Exploration of the Preparation Methods, Structure, and Spectroscopic and Electrochemical Properties.
Authors: Wang Rongming , Xu Wei , Zhang Jian , Li Lijuan 
Published: July 2010

AbstractThe structures of the nitrosyl complexes (II) and (IV) are determined by single crystal XRD.
ChemInform Abstract: Chemoenzymatic Synthesis and Application of Bicyclo[2.2.2]octadiene Ligands: Increased Efficiency in Rhodium‐Catalyzed Asymmetric Conjugate Additions by Electronic Tuning.
Authors: Luo Yunfei , Carnell Andrew J. 
Published: July 2010

AbstractA new series of 1,4‐disubstituted 2,5‐diaryl bicyclo[2.2.2]octadienes are prepared.
ChemInform Abstract: New Ionic Phosphite Ligands: Synthesis and Application in Asymmetric Rh‐Catalyzed Hydrogenation.
Authors: Lyubimov S. E. , Petrovskii P. V. , Davankov V. A. 
Published: July 2010

AbstractThe chiral phosphites are based on pyridinium and imidazolium ionic liquids and are coordinated in the monodendate mode to afford rhodium complexes.
ChemInform Abstract: Exploring the Versatility of the Johnson—Claisen Rearrangement: Access to Functionally Versatile δ‐Ethoxycarbonyl‐α,β‐unsaturated Nitriles.
Authors: Cosgrove Kelly L. , McGeary Ross P. 
Published: July 2010

AbstractThe cyanohydrin educts are prepared following 2 different procedures [cf.
ChemInform Abstract: α‐ and β‐Stannyl Trifluoromethylbutenoates: Regioselective Preparation and Use in Copper(I)‐Catalyzed Allylation and Propargylation Reactions.
Authors: Carcenac Yvan , Zine Khalid , Kizirian Jean‐Claude , Thibonnet Jerome , Duchene Alain , Parrain Jean‐Luc , Abarbri Mohamed 
Published: July 2010

AbstractThe first highly regioselective free‐metal hydrostannylation of butynoate (I) without any additive is reported.
ChemInform Abstract: Iridium‐Catalyzed C—H Activation/Borylation/Oxidation for the Preparation of Bis‐Protected Phloroglucinol Derivatives.
Authors: Marshall Laura J. , Cable Karl M. , Botting Nigel P. 
Published: July 2010

AbstractThe two‐step procedure includes Ir‐catalyzed C—H activation and borylation of resorcinols (I) followed by oxidation of boronic ester intermediates (II) to give the derivatives (III).
ChemInform Abstract: Iodine as a Versatile Catalyst for the Hydroalkylation of Vinyl Arenes with 1,3‐Diketones.
Authors: Yadav J. S. , Reddy B. V. Subba , Rao T. Srinivasa , Bhavani K. , Raju A. 
Published: July 2010

AbstractAn efficient protocol is developed.
ChemInform Abstract: The Mukaiyama Aldol and Mukaiyama—Michael Reactions Promoted by Commercially Available Molecular Sieves.
Authors: Anada Masahiro , Washio Takuya , Watanabe Yudai , Hashimoto Shunichi 
Published: July 2010

AbstractThe Mukaiyama aldol reactions of aldehydes (I) and (IV) with silyl ketene acetals or silyl enol ethers (II) proceed smoothly in the presence of pulverized mol.
ChemInform Abstract: Low‐Temperature Ag/Pd‐Catalyzed Decarboxylative Cross‐Coupling of Aryl Triflates with Aromatic Carboxylate Salts.
Authors: Goossen Lukas J. , Lange Paul P. , Rodriguez Nuria , Linder Christophe 
Published: July 2010

AbstractThe present protocol, allowing for coupling of halogenated and heterocyclic arenecarboxylates at only 130°C, marks an important milestone in the development of decarboxylative cross‐coupling reactions into practicable alternatives to the established coupling of metalorganic compounds.
ChemInform Abstract: Inverse Electron Demand Asymmetric Cycloadditions of Cyclic Carbonyl Ylides Catalyzed by Chiral Lewis Acids — Scope and Limitations of Diazo and Olefinic Substrates.
Authors: Suga Hiroyuki , Higuchi Satoshi , Ohtsuka Motoo , Ishimoto Daisuke , Arikawa Tadashi , Hashimoto Yuta , Misawa Shunta , Tsuchida Teruko , Kakehi Akikazu , Baba Toshihide 
Published: July 2010

AbstractThe reaction of activated olefins with carbonyl ylides, generated by Rh‐catalyzed decomposition of the corresponding α‐diazocarbonyl compounds, is investigated in the presence of transition metal triflates and Pybox or BINIM‐type ligands as catalysts (to be continued).
ChemInform Abstract: Chemistry of Iminofurans. Part 5. Synthesis, Structure, and Cyclization of 4‐R‐4‐Oxo‐2‐[2‐(2‐oxo‐1,2‐diphenylethylidene)hydrazino]but‐2‐enoic Acids.
Authors: Komarova O. A. , Igidov N. M. , Rubtsov A. E. , Zalesov V. V. , Makarov A. S. , Toksarova Yu. S. 
Published: July 2010

AbstractThe title compounds (III) exist in solution as Z‐ and E‐enehydrazino‐ or β‐ketohydrazone forms.
ChemInform Abstract: Novel Entry into 5‐Decarboxydibenzofurans via Smiles Rearrangement of the Lichen para‐Depside, Erythrin.
Authors: Thadhani Vinitha M. , Choudhary Muhammad Iqbal , Andersen Raymond J. , Karunaratne Veranja 
Published: July 2010

AbstractSmiles rearrangement of erythrin (I) provides access to diaryl ethers having a free carboxylic acid at the α‐position.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of Polyfunctionalized 3‐(Cyclohexenylmethyl)‐indoles via a Quadruple Domino Friedel—Crafts‐Type/Michael/Michael/Aldol Condensation Reaction.
Authors: Enders Dieter , Wang Chuan , Mukanova Meruyert , Greb Andreas 
Published: July 2010

AbstractThe one‐pot multi‐component process involves the cascade reaction of nitroalkenes (II), indole derivatives (I) and two equivalents acrolein (III) catalyzed by a prolinol Tms‐ether derivative.
ChemInform Abstract: Direct Experimental Evidence for the Priority of Flexible Ligand Skeleton in Asymmetric Friedel—Crafts Alkylation of Indole with Nitroalkenes.
Authors: Liu Han , Wang Neng‐Dong , Du Da‐Ming 
Published: July 2010

AbstractCompared with diphenylamine‐linked ligands investigated in previous studies the newly designed ligands (I) with planar rigid scaffold give much lower yields and enantioselectivities.
ChemInform Abstract: Extension of a Cascade Reaction: Microwave‐Assisted Synthesis of the GFP Chromophore Derivatives.
Authors: Jia Runhong , Yan Shu , Jiang Bo , Shi Feng , Tu Shu‐Jiang 
Published: July 2010

AbstractValuable features of this cascade reaction are high yields and the prospect of small‐scale high‐speed syntheses for substance libraries.
ChemInform Abstract: Pd‐Catalyzed Reactions on Pyridinium N‐Heteroarylaminides. Step‐by‐Step Synthesis of 3,5‐Unsymmetrically Disubstituted 2‐Aminopyridines.
Authors: Cordoba Marta , Castillo Rafael R. , Izquierdo M. Luisa , Alvarez‐Builla Julio 
Published: July 2010

AbstractThe method applies a multiple Suzuki—Miyaura cross‐coupling reaction [cf.
ChemInform Abstract: Synthesis of Substituted Isoquinolines via Nickel‐Catalyzed [2 + 2 + 2] Cycloaddition of Alkynes and 3,4‐Pyridynes.
Authors: Iwayama Toshihiko , Sato Yoshihiro 
Published: July 2010

AbstractButyndiol derivatives (II) and diynes (IV) are suitable substrates for the cycloaddition with pyridines (I) in the presence of a fluoride anion.
ChemInform Abstract: Synthesis of Methyl 12‐Aryl‐9,9‐dimethyl‐11‐oxo‐7,8,9,10,11,12‐hexahydrobenzo [a]acridine‐10‐carboxylate.
Authors: Kozlov N. G. , Bondarev S. L. , Kadutskii A. P. , Basalaeva L. I. 
Published: July 2010

AbstractThe title compounds are obtained in a three‐component condensation of 2‐naphthylamine, aromatic aldehydes, and 2,2‐dimethyl‐4,6‐dioxocyclohexanecarboxylate.
ChemInform Abstract: A Novel Synthetic Route to Synthesize 2,4,8,10‐Tetraoxaspiro[5.5]‐undecane from Formaldehyde under Hydrothermal Conditions.
Authors: Maheen Gull , Tian Ge , Song Zhiguang , He Chao , Shi Zhan , Liu Ziwei , Yuan Hongming , Feng Shouhua 
Published: July 2010

AbstractThe presented method is described as the simplest one to synthesize title compound (II).
ChemInform Abstract: A New Method for Pyrrole peri‐Annulation: Synthesis of 1H‐1,5,7‐Triazacyclopenta[c,d]phenalenes from 1H‐Perimidines.
Authors: Aksenov Alexander V. , Lyakhovnenko Alexander S. , Andrienko Anna V. , Levina Irina L. 
Published: July 2010

AbstractThe synthesis of title compounds (III) from acetylperimidines (II) involves the formation of an amide intermediate which reacts with triazines or carboxylic acids.
ChemInform Abstract: Ternary Condensation of Biginelli Thiones, Chloroacetic Acid, and Aldehydes as an Effective Approach Towards Thiazolo[3,2‐a]pyrimidines and 5‐Arylidenethiazolidine‐2,4‐diones.
Authors: Lebedyeva Iryna O. , Povstyanoy Mykhaylo V. , Ryabitskii Aleksey B. , Povstyanoy Vyacheslav M. 
Published: July 2010

AbstractThe three‐component reaction of thiones (I) with aldehydes (II) and chloroacetic acid readily affords thiazolo[3,2‐a]pyrimidines (IV), whilst prolonged reaction times leads to the formation of hydrolysis products (V).
ChemInform Abstract: Synthetic and Mechanistic Studies of the Aza‐Retro‐Claisen Rearrangement. A Facile Route to Medium Ring Nitrogen Heterocycles.
Authors: Boeckman Robert K. Jr. , Genung Nathan E. , Chen Ke , Ryder Todd R. 
Published: July 2010

AbstractHeating of oxepines and oxacenes of type (I) and (IV) as well as cyclobutanecarboxaldehydes like (VII) with Staudinger reagents is found to provide an efficient approach to medium ring nitrogen heterocycles.
ChemInform Abstract: Stereoselective Synthesis of Configurationally Stable Functionalized ethano‐Bridged Troeger Bases.
Authors: Michon Christophe , Sharma Ankit , Bernardinelli Gerard , Francotte Eric , Lacour Jerome 
Published: July 2010

AbstractA novel [1,2]‐Stevens rearrangement of quaternary ammonium salts (I) leads readily to ethano‐bridged Troeger bases (II) as a single diastereomer.
ChemInform Abstract: Facile Synthesis and Ring‐Opening of 4‐(Tributylstannyl)pyrrolidine‐2‐carboxylates.
Authors: Shimizu Makoto , Ando Hiromi , Shibuya Hitoshi , Hachiya Iwao 
Published: July 2010

AbstractOn treatment of imino acetate (II) with stannylalkenes (I) in the presence of MesOH at ‐78 °C a ring‐closing reaction occurs to give stannyl‐pyrrolidines (III) as major products.
ChemInform Abstract: Synthetic Study on Clutiolide Based on a Remote Chelation Controlled Ireland—Claisen Rearrangement.
Authors: Ishihara Jun , Tokuda Okihisa , Shiraishi Kazunori , Nishino Yukihiro , Takahashi Keisuke , Hatakeyama Susumi 
Published: July 2010

AbstractThe strategy leading to clutiolide (VI), a secolabdane diterpene from C.
ChemInform Abstract: Facile Synthesis of Novel Glycosyl Carboxamide with Sugar in Furanose and Pyranose form Using Benzotriazole Methodology.
Authors: Kale Raju R. , Prasad Virendra , Tiwari Vinod K. 
Published: July 2010

AbstractA simple method using mild conditions for the preparation of secondary and tertiary glycosyl amides (III) and (V) is described by treatment of sugar‐based N‐acylbenzotriazoles (I) and (IV) with the corresponding amines (II).
ChemInform Abstract: Determination of the Absolute Configuration of Marine Oxylipin Topsentolide A1 by the Synthesis of the Enantiomer of the Natural Product.
Authors: Kobayashi Munetaka , Ishigami Ken , Watanabe Hidenori 
Published: July 2010

AbstractThe stereochemistry of (I), a cytotoxic oxylipin against human solid tumor cells, is assigned by synthesis of its enantiomer and a diastereomer.
ChemInform Abstract: Determination of the Absolute Configuration of Nodulisporacid A by the Concise Synthesis of Four Stereoisomers via Three‐Component Reaction and One‐Pot Construction of the Framework.
Authors: Sumiya Tatsunobu , Ishigami Ken , Watanabe Hidenori 
Published: July 2010

AbstractFour stereoisomers are synthesized and the absolute stereochemistry of the natural product, which exists as an equilibrium mixture of (E)‐ and (Z)‐isomers, is revealed as (I).
ChemInform Abstract: Cinchona Alkaloids and Their Derivatives as Chirality Inducers in Metal‐Promoted Enantioselective Carbon—Carbon and Carbon—Heteroatom Bond‐Forming Reactions
Authors: Deshmukh Ravindra R. , Ryu Do Hyun , Song Choong Eui 
Published: July 2010

AbstractReview: 103 refs.
Maintenance therapy with low‐dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome
Authors: de Lima Marcos , Giralt Sergio , Thall Peter F. , de Padua Silva Leandro , Jones Roy B. , Komanduri Krishna , Braun Thomas M. , Nguyen Hoang Q. , Champlin Richard , Garcia‐Manero Guillermo 
Published: July 2010

AbstractBACKGROUND:Recurrence is a major cause of treatment failure after allogeneic transplantation for acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS), and treatment options are very limited. Azacitidine is a DNA methyltransferase inhibitor with activity in myeloid disease. The authors hypothesized that low‐dose azacitidine administered after transplant would reduce recurrence rates, and conducted a study to determine a safe dose/schedule combination.METHODS:Forty‐five high‐risk patients were treated. Median age was 60 years; median number of comorbidities was 3; 67% were not in remission. By using a Bayesian adaptive method to determine the best dose/schedule combination based on time to toxicity, the authors investigated combinations of 5 daily azacitidine doses, 8, 16, 24, 32, and 40 mg/m2, and 4 schedules: 1, 2, 3, or 4 cycles, each with 5 days of drug and 25 days of rest. Cycle 1 started on Day +40.RESULTS:Reversible thrombocytopenia was the dose‐limiting toxicity. The optimal combination was 32 mg/m2 given for 4 cycles. Median follow‐up was 20.5 months. One‐year event‐free and overall survival were 58% and 77%, justifying further studies to estimate long‐term clinical benefit. No dose significantly affected DNA global methylation.CONCLUSIONS:Azacitidine at 32 mg/m2 given for 5 days is safe and can be administered after allogeneic transplant for at least 4 cycles to heavily pretreated AML/MDS patients. The trial also suggested that this treatment may prolong event‐free and overall survival, and that more cycles may be associated with greater benefit. Cancer 2010. © 2010 American Cancer Society.
Clavulanic acid protects neurons in pharmacological models of neurodegenerative diseases
Authors: Huh Youngbuhm , Ju Mi Sun , Park Hanbyeol , Han Shengjun , Bang Yu‐Mi , Ferris Craig F. , Koppell Gary A. , King Jean A. , Kim Minkyu Leo , Kim Deog Joong , Ahn Chang Ho , Oh Myung‐Sook 
Published: July 2010

AbstractClavulanic acid is a psychoactive compound with excellent blood‐brain barrier permeability and safety profiles. Previous studies showed that clavulanic acid suppresses anxiety in rodents and in a primate model. In addition, clavulanic acid is thought to enhance sexual function in animal models via central nervous system (CNS) mechanisms. To further examine its potential as a CNS‐modulating agent, we investigated the effects of clavulanic acid in neurotoxin‐induced animal models that emulate neurodegenerative disease symptoms. Clavulanic acid was administered to rodents that were exposed to kainic acid or 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP). Using histochemical staining of brain sections, we demonstrated that clavulanic acid protects hippocampal and dopaminergic neurons from toxin‐induced acute death. We also observed that clavulanic acid improves motor function in MPTP‐treated mice in a behavioral test. These data indicate that clavulanic acid may have neuroprotective effects and warrants further investigation of its therapeutic use in CNS disorders, such as Parkinson's and Alzheimer's disease. Drug Dev Res 71:351–357, 2010. © 2010 Wiley‐Liss, Inc.
Flotillin‐1 promotes formation of glutamatergic synapses in hippocampal neurons
Authors: Swanwick Catherine Croft , Shapiro Marietta E. , Vicini Stefano , Wenthold Robert J. 
Published: July 2010

AbstractSynapse malformation underlies numerous neurodevelopmental illnesses, including autism spectrum disorders. Here we identify the lipid raft protein flotillin‐1 as a promoter of glutamatergic synapse formation. We cultured neurons from the hippocampus, a brain region important for learning and memory, and examined them at two weeks in vitro, a time period rich with synapse formation. Double‐label immunocytochemistry of native flot‐1 with glutamatergic and GABAergic synapse markers showed that flot‐1 was preferentially colocalized with the glutamatergic presynaptic marker vesicular glutamate transporter 1 (VGLUT1), compared to the GABAergic presynaptic marker glutamic acid decarboxylase‐65 (GAD‐65). Triple‐label immunocytochemistry of native flot‐1, VGLUT1, and NR1, the obligatory subunit of NMDA receptors, indicates that Flot‐1 was preferentially localized to synaptic rather than extrasynaptic NR1. Furthermore, electrophysiological results using whole‐cell patch clamp showed that Flot‐1 increased the frequency of miniature excitatory postsynaptic currents (mEPSCs) but not miniature inhibitory postsynaptic currents (mIPSCs), whereas amplitude and decay kinetics of either type of synaptic current was not affected. Corresponding immunocytochemical data confirmed that the number of glutamatergic synapses increased with flot‐1 overexpression. Overall, our anatomical and physiological results show that flot‐1 enhances the formation of glutamatergic synapses but not GABAergic synapses, suggesting that the role of flot‐1 in neurodevelopmental disorders should be explored. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 70: 875–883, 2010
Macroinvertebrate response to stream restoration by large wood addition
Authors: Testa Sam , Douglas Shields F. , Cooper Charles M. 
Published: July 2010

AbstractWe examined the aquatic macroinvertebrate community response to habitat rehabilitation activities in an incised, sand‐bed stream. Seventy‐two large wood (LW) structures were placed along 2 km of Little Topashaw Creek (37 km2 watershed) in north‐central Mississippi, USA. Macroinvertebrate collections were made from bed sediments, LW, leaf packs and qualitative multi‐habitat sampling during 2 years prior to and 2 years following LW addition. Addition of LW tripled the availability of wood substrate but had no measurable effect on macroinvertebrate abundance or family richness. Ordination analyses revealed subtle differences in community composition between treated and untreated conditions, but these were related to antecedent discharge (occurrence of high flows during the preceding 6 months) and bed sediment composition rather than the availability of LW. Restoration of incising, sand‐bed streams must include measures that address perturbed hydrology and degraded water quality as well as instream treatments. Published in 2010. This article is a US Government work and is in the public domain in the USA.
Dendritic cells in tolerance induction for the treatment of autoimmune diseases
Authors: Rescigno Maria 
Published: July 2010

AbstractAutoimmune diseases are characterized by the loss of tolerance toward self‐antigens and the induction of destructive immune responses leading to tissue damage. Most patients with autoimmune diseases are treated with immunosuppressive drugs that suppress the immune response in a non‐specific fashion, which is inevitably accompanied by several side effects. Antigen‐specific immunomodulation and patient‐tailored therapies are likely to solve these issues and to elicit long‐term protection against disease flares. This Viewpoint analyzes the potential use of DC for induction of antigen‐specific tolerance in autoimmune disease settings.
The puzzle of intestinal lamina propria dendritic cells and macrophages
Authors: Pabst Oliver , Bernhardt Günter 
Published: July 2010

AbstractA specialized network of immune cells is positioned directly in the mucosa of the intestinal tract. In this Viewpoint, we discuss the nature and function of DC and macrophages occupying the intestinal lamina propria of mice. DC and macrophages share phenotypic traits and functional plasticity, properties that preclude simple classification of the two cell types. Nevertheless, the information available appears to have reached “critical mass” to allow for a clear demarcation between intestinal macrophages and DC.
Psychosocial Characteristics in Relation to Disordered Eating Attitudes in Greek Adolescents
Authors: Costarelli V. , Antonopoulou K. , Mavrovounioti Ch. 
Published: July 2010

AbstractThe study explores possible links between eating attitudes in Greek adolescents and certain psychosocial characteristics such as self‐esteem, empathy and anxiety. A total of 202 students (109 boys and 93 girls), 15–18 years old, have been recruited. The following questionnaires were used: the Eating Attitudes Test (EAT‐26), the State‐Trait Anxiety Inventory, the Self‐Perception Profile for Adolescents, the Multidimensional Body‐Self‐Questionnaire‐Overweight Preoccupation and the Index of Empathy of Children and Adolescents. The EAT‐26 revealed that 18.3% of the total sample of students (12.8% of boys and 24.7% of girls) reported having disordered eating attitudes. Adolescents with disordered eating attitudes had significantly higher levels of anxiety and scored less in self‐reported physical appearance and romantic appeal. Empathy and global self‐esteem did not differ significantly between the two groups. Adolescents with disordered eating attitudes have certain psychosocial characteristics which differentiate them from the students with healthier eating attitudes. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.
Novel antifouling agent zinc pyrithione: determination, acute toxicity, and bioaccumulation in marine mussels (Mytilus galloprovincialis)
Authors: Marcheselli Marco , Rustichelli Cecilia , Mauri Marina 
Published: July 2010

Abstract
Antifouling biocide zinc pyrithione (ZnPT) and its biological fate have received little attention because this compound was assumed not to be persistent in marine ecosystems. An analytical procedure was developed that has proved to be efficient and very sensitive in extracting ZnPT and its main secondary products, Zn and ionized pyrithione (PT−), from both seawater and biological samples, namely in the gills and digestive gland of the bioindicator species Mytilus galloprovincialis. Short-term experiments were carried out to investigate ZnPT toxicity and bioaccumulation. The effects on survival and tissue bioaccumulation of ZnPT and its secondary products were studied on adult mussels from a natural population, collected in the harbor area of Porto Santo Stefano (Italy) and exposed to sublethal doses of the biocide for up to 7 d. Zinc pyrithione was shown to be persistent in the experimental seawater in the short term. A basal level of ZnPT and ionized PT− was detected in the mussels, indicating that ZnPT availability in the sampling site is already high enough to induce a detectable accumulation in individuals of the native population. Zinc pyrithione rapidly accumulated in the tissues of the exposed mussels, proportionately to both exposure concentration and time, identifying the gills and digestive gland as important targets in the biological pathway of the contaminants. Even though the 7-d median lethal concentration (LC50) = 8.27 µM established here appears high with respect to reported ZnPT environmental concentrations, the results indicate that this biocide could represent a threat for marine organisms in coastal environments and that further investigations on its biological effects at sublethal doses are needed. Environ. Toxicol. Chem. 2010;29:2583–2592. © 2010 SETAC