bluuebunny/crossref_metadata_2025_split huggingface dataset:
Créativité du processus primaire
Authors: Rolland Jean-Claude 
Published: June 2012

Résumé Le déclin du complexe d’Œdipe, pensé par Freud comme une nécessité naturelle, est pourtant source de vives souffrances. Le travail de la cure s’engage dans la suite du renoncement aux attachements premiers ; comme le travail du rêve, il permet une figuration des objets œdipiens intériorisés, qu’ils aient été refoulés ou introjectés. Dans les deux cas, l’interprétation – souvent sur un mode analogique – transforme l’objet, la parole venant relayer les images ou ouvrir un écart dans l’espace psychique, à l’opposé de l’enfouissement mélancolique. C’est ce versant créatif des processus inconscients qui est ici déployé.
Le procédé et la règle : l'association libre analytique
Authors: Donnet Jean-Luc 
Published: June 2012

Résumé « L’association libre » reste inscrite au cœur de la méthode analytique, mais l’évolution des conceptions de la cure rend délicate l’évaluation de ses enjeux pratiques et métapsychologiques. Pour tenter de les préciser, l’auteur fait jouer une distinction entre « association libre » et « associativité » : la première résulte de l’utilisation volontaire, par un sujet conscient, d’un « procédé destiné à l’investigation de processus psychiques à peu près inaccessibles autrement » (Freud) ; la seconde fait référence aux enchaînements associatifs, éventuellement involontaires, inconscients, qui, dans la situation cadrée, sous l’égide de la règle fondamentale, s’inscrivent dans le processus constitutif de la cure. En déployant diverses facettes de cette opposition, l’auteur montre comment l’objectivation d’un déterminisme inconscient visée par le procédé se trouve remise en cause par les implications de la règle : l’accouplement association libre-attention en égal suspens aboutissant au privilège méthodologique du couple transfert/contre-transfert.
Diplomatique et discours politiques. Une analyse lexicographique qualitative et quantitative des ordonnances de Philippe le Bon pour la Flandre (1419-1467)
Authors: Braekevelt Jonas , Dumolyn Jan 
Published: June 2012

Résumé Le présent article veut considérer l’activité législative des ducs de Bourgogne de la maison de Valois comme le résultat d’une forme de communication politique entre le prince et ses sujets. En tant que tel, il traite le contenu des ordonnances ducales comme incorporant divers langages ou discours idéologiques, parfois même antagonistes. En focalisant la recherche sur des édits datant du règne de Philippe le Bon, qui formait l’apogée du pouvoir de l’« État bourguignon », cette contribution tâte l’évolution d’allocutions législatives plutôt « dialogiques », incorporant des notions populaires, vers un discours princier « hégémonique ». Ce sondage s’effectue grâce à l’utilisation d’un logiciel lexicographique (Hyperbase) , qui permet également l’identification de l’emploi dans les ordonnances ducales, dans des contextes politiques spécifiques, de diverses chaînes de signifiants propres au duc ou aux organes représentatives de ses sujets. Ainsi, la législation se révèle non seulement en tant qu’exécutante d’un politique princier ou le résultat de conflits politiques, mais aussi comme un champ de bataille idéologique évoluant.
Hip Stability after Ligamentum Teres Resection during Surgical Dislocation for Cam Impingement
Authors: Phillips Alistair R. , Bartlett Gavin , Norton Mark , Fern Darren 
Published: June 2012

Purpose The purpose of this study was to investigate whether patients who have undergone surgical hip dislocation with excision of the ligamentum teres exhibited symptoms of a Type I ligamentum teres rupture. Method A questionnaire was designed to enquire about specific symptoms attributed to Type I injuries (complete rupture) in the literature: gross instability, incomplete reduction, inability to bear weight and mechanical symptoms. 217 consecutive patients were surveyed and 161 patients (75%) returned 168 questionnaires (75%). Mean age was 34 and median follow-up was 51 months (35 to 97). Results All patients were able to fully weight bear after surgery while 77% experienced no groin pain and 61% experienced no pain on exercise. 35% of patients experienced popping and locking in their operated hip and 24% had subjective feeling of their hip giving way. Conclusion Patients who have had surgical excision of the ligamentum teres during open osteochondroplasty for cam deformities do not exhibit symptoms of a Type I ligamentum teres rupture. Our results show that minor instability symptoms may be present but symptoms present more like to Type II (partial) injuries. We propose that Type II injuries be divided into Type IIa; partial tear and Type IIb; iatrogenic rupture.
Association between Trauma and Cancer of the Testis: The Importance of Self-Palpation of the Testis for the Early Detection: Two Case Reports
Authors: Polito Massimo , Catanzariti Francesco , Quaresima Luigi , Milanese Giulio , Muzzonigro Giovanni 
Published: June 2012

Introduction Cancer of the testis is not always early detected and recognised, both by the physician and by the patient: sometimes physicians do not make an accurate genitals exam while patients often underestimate this problem. Case reports Case I 42-year-old man accepted from another hospital's Emergency, because of pain and edema of the right testis after a recent trauma on the gonad. At US, evidence of increased volume of the right testis with a large intraparenchymal hematoma. The markers were higher than normal. We performed a right orchiecthomy The pathologist noted the presence of a mixed cancer of the testis (95% embryonal, 5% seminoma). Case II 49-year-old man with hematuria, accepted from Emergency. The abdominal US revealed the presence of a voluminous neoformation (diameter of 12 cm) of the right kidney with neoplastic throm-bosis of the right kidney vein. At the general physical exam, we detected the presence of an increased right testis, that at the US appared to be suspicious for cancer. Tumor markers were normal with the exception of αFP. We performed right nephro-adrenalectomy, right orchiectomy and removal of local nodes. The definitive histological examination demonstrated the presence of a seminoma of the testis and papillary carcinoma of the kidney with node metastasis. Discussion Current studies showed an association between trauma and cancer of the testis, even if some authors did not find this association because they consider that patients with trauma undergo US and in that occasion cancer is incidentally detected. Conclusions The association between trauma and cancer of the testis is controversial in current studies. Furthermore screening for the cancer of the testis does not seem to be useful, even if the self- and the physician's palpation of the testis seem to be very important because in these two cases they should allow the early detection of the condition, with a resulting better prognosis.
A Defense of a Thomistic Concept of the Just Price
Authors: Koehn Daryl , Wilbratte Barry 
Published: June 2012

ABSTRACT:Since St. Thomas Aquinas was one of the first scholastics to analyze the idea of a “just price,” economists, economic historians and philosophers interested in the philosophical underpinnings of the market have focused on Aquinas’s writings. One group insists that Aquinas defined the just price as the payment needed to cover sellers’ labor and material costs. A second camp vehemently counters that Aquinas’s just price is simply the going market price. We argue that neither of these views is correct. The Thomistic just price is the price that would be agreed to by a just person as part of an exchange. This “just person price” takes into account the well-being of the individual transactors and the good of the entire community. Such a price reduces neither to the cost-covering price nor to the market exchange price. A Thomistic concept of the just person price deserves to be reconsidered, especially because a Thomistic approach offers some useful ways to deal with issues quite differently from the popular neoclassical approach directed toward arriving at a socially optimal market price.
Valorisation des terroirs et économie morale au 21e siècle : le cas des fromages fins du Québec
Authors: Boulianne Manon 
Published: June 2012

La question de comment les fromages fins fabriqués au Québec sont devenus emblématiques des terroirs québécois alors qu’ils résultent de « traditions inventées » guide un travail de recherche empirique ayant pris la région de Chaudière-Appalaches pour site principal. On y a mobilisé une méthodologie relevant de l’analyse de filière et considéré, dans une perspective anthropologique, les dimensions matérielles et symboliques des procès de production, des réseaux de distribution et des stratégies de mise en marché qui caractérisent la filière fromagère. Les données recueillies à ce jour indiquent que l’engouement suscité autour des fromages fins produits au Québec pourrait être lié au déploiement d’une économie morale qui, dans le contexte de la globalisation, accorde une valeur accrue aux produits de proximité.
Language Testing in the Government and Military
Authors: Malone Margaret E. , Brooks Rachel Lunde 
Published: June 2012

AbstractLanguage testing in the context of the government and military most often refers to measuring language proficiency: the functional ability of personnel to complete operational tasks in the target language. While many associate government and military testing with proficiency testing, both government and military also rely on performance, aptitude, diagnostic, and achievement tests. Worldwide, government and military organizations face ever‐increasing demands for personnel with various levels of language ability, providing a continual need for testing.
Holistic Versus Featural Facial Composite Systems for People with Mild Intellectual Disabilities
Authors: Gawrylowicz Julie , Gabbert Fiona , Carson Derek , Lindsay William R. , Hancock Peter J.B. 
Published: June 2012

SummaryLimited verbal abilities might act as a barrier to witnesses with Intellectual Disabilities (ID) to provide accurate testimony. This might be particularly problematic when the police need to create a facial composite image. Contrary to featural composite systems such as Electronic Facial Identification Technique (E‐FIT), holistic systems such as Evolutionary Facial Identification Technique (EvoFIT) do not require the witness to provide a verbal description of a perpetrator's face. Instead, they rely more on face recognition, which may make them more suitable for people with ID. The current study compared the performance of people with and without ID at creating composites using E‐FIT and EvoFIT. Although ID composites created with EvoFIT were more often accurately identified than E‐FIT composites, the performance of ID participants was overall very poor across both systems and considerably poorer than that of non‐ID participants. The implications of these findings for practitioners working in the Criminal Justice System are discussed. Copyright © 2012 John Wiley & Sons, Ltd.
Occupational benzene exposure and the risk of chronic myeloid leukemia: A meta‐analysis of cohort studies incorporating study quality dimensions
Authors: Vlaanderen Jelle , Lan Qing , Kromhout Hans , Rothman Nathaniel , Vermeulen Roel 
Published: June 2012

AbstractObjectiveWe documented previously that if study quality is accounted for, evidence from occupational cohort studies on benzene supports a possible association with some lymphoma subtypes, in particular multiple myeloma, and acute and chronic lymphocytic leukemia. Here, we extend these analyses to chronic myeloid leukemia (CML).MethodsThree strategies to assess study quality (stratification by the year‐of‐start of follow‐up, stratification by the strength of the reported acute myeloid leukemia (AML) association, and stratification by the quality of benzene exposure assessment) were employed in a meta‐analysis of occupational benzene exposure and CML. We hypothesized that stratification by these study quality dimensions would identify a subgroup of occupational cohort studies that is most informative for the evaluation of the possible association between benzene and CML.ResultsThe overall meta‐relative risk (mRR) was non‐significantly elevated (1.23; 95% confidence interval (CI): 0.93–1.63). The mRRs increased with increasing study quality for all dimensions with a significant elevation for studies with start of follow‐up after 1970 (1.67; 95% CI: 1.02–2.74). The highest study quality stratum for AML significance and exposure quality showed an elevated but non‐significant increased mRR (1.40; 95% CI: 0.86–2.27, and 1.68; 95% CI: 0.74–3.84, respectively).ConclusionsAlthough limited by low statistical power, the current meta‐analysis provides support for a possible association of occupational exposure to benzene and the risk of CML. Am. J. Ind. Med. 55:779–785, 2012. © 2012 Wiley Periodicals, Inc.
Preparation and properties of rigid polyimide foams derived from dianhydride and isocyanate
Authors: Yu Fei , Wang Kai , Liu Xiao‐Yan , Zhan Mao‐Sheng 
Published: June 2012

AbstractA series of rigid polyimide (PI) foams were synthesized via the reaction of a first solution with a second solution. The first solution was isocyanate‐terminated polyimide prepolymers; the second solution contained deionized water and surfactant. The effect of different water contents and isocyanate index on the structures and properties of rigid PI foams were investigated. The apparent density, hardness, compressive strength, and the 5% weight loss temperatures (T5%) decreased with the increase of water content. With the increase of isocyanate index, the apparent density and the T5% values decreased, whereas the glass transition temperatures (Tg) increased and the hardness, compressive strength first increased and then decreased. The rigid PI foams composed of closed‐cells were confirmed by scanning electron microscopy. The maximum compressive strength of rigid PI foams prepared was up to 1.31 MPa. Moreover, excellent thermal stability was presented with the T5% values were all above 360°C and the residual weights of the foams (Rw) were more than 50% at 800°C. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Structure, thermal, and mechanical properties of DDM‐hardened epoxy/benzoxazine hybrids: Effects of epoxy resin functionality and ETBN toughening
Authors: Grishchuk Sergiy , Sorochynska Liubov , Vorster Olof C. , Karger‐Kocsis József 
Published: June 2012

AbstractBifunctional, trifunctional, and tetrafunctional epoxy (EP) resins were hardened with stoichiometric amount of 4,4′‐diaminodiphenyl methane in presence and absence of benzoxazine (BOX). The EP/BOX ratio of the hybrid systems was constant, viz. 50/50 wt %. For the bifunctional EP, the EP/BOX range covered the ratios 75/25 and 25/75 wt %, as well. Epoxy‐terminated liquid nitrile rubber (ETBN) was incorporated in 10 wt % in the systems with trifunctional and tetrafunctional EP, and in 10, 15, and 20 wt % in the EP/BOX with bifunctional EP to improve their toughness. Information on the structure and morphology of the hybrid systems was received from differential scanning calorimetric, dynamic‐mechanical thermal analysis, atomic force microscopic, and scanning electron microscopic studies. The flexural, fracture mechanical properties, thermal degradation, and fire resistance of the EP/BOX and EP/BOX/ETBN hybrids were determined. It was found that some homopolymerized BOX was built in the EP/BOX conetwork in form of nanoscale inclusions, whereas ETBN formed micron scaled droplets of sea‐island structure. Incorporation of BOX improved the charring and fire resistance, enhanced the flexural modulus and strength, reduced the glass transition (Tg), the fracture toughness, and energy. Additional modification with ETBN decreased the charring, fire resistance, flexural modulus and strength, as well as Tg, however, improved the fracture toughness and especially the fracture energy. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Testing the Use of Geostatistics to Improve Data Visualization. Case Study on GPR Survey of Tarragona's Cathedral
Authors: Tamba Robert 
Published: June 2012

ABSTRACTA ground‐penetrating radar survey was conducted inside the Cathedral of Tarragona in order to explore the first 2 m beneath the ground surface. Initial processing and interpretation revealed a square perimeter related to a massive structure between 1 and 1.4 m below the ground surface. The results of the survey were used to test geostatistical tools by achieving a quantified data analysis and by filtering the data. The data analysis provided a description of the resolution and of the spatial distribution of the data. It included the characterization of the acquisition noise that was then filtered out by factorial kriging. This filtering technique allowed removing the acquisition noise, before the time‐slice computation or any interpolation of the data, using weights of interpolation that are based on the spatial variations of the data. Having performed the filtering on the data at acquisition sampling allowed the use of optimized parameters for the visualization of the results, without having to remove remaining acquisition noise with the visualization operators. Copyright © 2012 John Wiley & Sons, Ltd.
The parasitic helminth product ES‐62 suppresses pathogenesis in collagen‐induced arthritis by targeting the interleukin‐17–producing cellular network at multiple sites
Authors: Pineda Miguel A. , McGrath Mairi A. , Smith Pauline C. , Al‐Riyami Lamyaa , Rzepecka Justyna , Gracie J. Alastair , Harnett William , Harnett Margaret M. 
Published: June 2012

AbstractObjectiveAmong many survival strategies, parasitic worms secrete molecules that modulate host immune responses. One such product, ES‐62, is protective against collagen‐induced arthritis (CIA), a model of rheumatoid arthritis (RA). Since interleukin‐17 (IL‐17) has been reported to play a pathogenic role in the development of RA, this study was undertaken to investigate whether targeting of IL‐17 may explain the protection against CIA afforded by ES‐62.MethodsDBA/1 mice progressively display arthritis following immunization with type II collagen. The protective effects of ES‐62 were assessed by determination of cytokine levels, flow cytometric analysis of relevant cell populations, and in situ analysis of joint inflammation in mice with CIA.ResultsES‐62 was found to down‐regulate IL‐17 responses in mice with CIA. First, it acted to inhibit priming and polarization of IL‐17 responses by targeting a complex IL‐17–producing network, involving signaling between dendritic cells and γ/δ or CD4+ T cells. In addition, ES‐62 directly targeted Th17 cells by down‐regulating myeloid differentiation factor 88 expression to suppress responses mediated by IL‐1 and Toll‐like receptor ligands. Moreover, ES‐62 modulated the migration of γ/δ T cells and this was reflected by direct suppression of CD44 up‐regulation and, as evidenced by in situ analysis, dramatically reduced levels of IL‐17–producing cells, including lymphocytes, infiltrating the joint. Finally, there was strong suppression of IL‐17 production by cells resident in the joint, such as osteoclasts within the bone areas.ConclusionOur findings indicate that ES‐62 treatment of mice with CIA leads to unique multisite manipulation of the initiation and effector phases of the IL‐17 inflammatory network. ES‐62 could be exploited in the development of novel therapeutics for RA.
Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody–associated vasculitis
Authors: Smith Rona M. , Jones Rachel B. , Guerry Mary‐Jane , Laurino Simona , Catapano Fausta , Chaudhry Afzal , Smith Kenneth G. C. , Jayne David R. W. 
Published: June 2012

AbstractObjectiveRituximab is effective induction therapy in refractory or relapsing antineutrophil cytoplasmic antibody–associated vasculitis (AAV). However, further relapse is common, and maintenance strategies are required. The aim of this study was to reduce relapse rates using a fixed‐interval rituximab re‐treatment protocol.MethodsRetrospective, standardized collection of data from sequential patients receiving rituximab for refractory or relapsing AAV at a single center was studied. Group A patients (n = 28) received rituximab induction therapy (4 infusions of 375 mg/m2 or 2 infusions 1 gm) and further rituximab at the time of subsequent relapse. Group B patients (n = 45) received routine rituximab re‐treatment for 2 years: 2 doses of 1 gm each for remission induction, then 1 gm every 6 months (total of 6 gm). Group C patients (n = 19) comprised patients in group A who subsequently relapsed and began routine re‐treatment for 2 years.ResultsResponse (complete/partial remission) occurred in 26 of the 28 patients (93%) in group A, 43 of the 45 patients (96%) in group B, and 18 of the 19 patients (95%) in group C. At 2 years, relapses had occurred in 19 of 26 patients (73%) in group A, 5 of 43 (12%) in group B (P < 0.001), and 2 of 18 (11%) in group C (P < 0.001). At the last followup (median of 44 months), relapses had occurred in 85% of those in group A (22 of 26), 26% of those in group B (11 of 43; P < 0.001), and 56% of those in group C (10 of 18; P = 0.001). Glucocorticoid dosages were decreased and immunosuppression therapy was withdrawn in the majority of patients. Routine rituximab re‐treatment was well tolerated, and no new safety issues were identified.ConclusionTwo‐year, fixed‐interval rituximab re‐treatment was associated with a reduction in relapse rates during the re‐treatment period and a more prolonged period of remission during subsequent followup. In the absence of biomarkers that accurately predict relapse, routine rituximab re‐treatment may be an effective strategy for remission maintenance in patients with refractory and relapsing AAV.
An update view on the substrate recognition mechanism of phosphodiesterases: A computational study of PDE10 and PDE4 bound with cyclic nucleotides
Authors: Lau Justin Kai‐Chi , Cheng Yuen‐Kit 
Published: June 2012

AbstractEarly studies strongly implied that the specificity of cyclic nucleotide phosphodiesterases (PDEs) toward its endogenous substrates can be uniquely determined by the amido orientation of the invariant glutamine locating in the binding pocket of the enzyme. However, recently solved crystal structures of PDE4 (cAMP specific) and PDE10 (dual specific) in the presence of endogenous substrates have revealed that their invariant glutamine orientations are very similar despite exhibiting different substrate specificities proven physiologically. To understand this subtle specificity issue in the PDE family, here several experimentally inaccessible PDE–substrate complex models have been studied computationally, and the results are juxtaposed and compared in detail. Modeling results show that PDE10 in fact favors cAMP energetically but still can bind to cGMP owing to the robust hydrogen‐bond network in the vicinity of the invariant glutamine side chain. PDE4 fails to accommodate cGMP is correlated to the weakening of this same hydrogen‐bond network but not owing to any steric strain in the binding pocket. An Asn residue in the binding pocket of PDE4 has enhanced the specificity of the binding to cAMP sideway as observed in our computer simulation. Further to the previously studied syn‐ versus anti‐conformational specificity of cAMP in PDE10, the unexpected substrate‐binding mode in PDE10 versus PDE4 as reported here strongly suggested that there are remaining uncertainties in the substrate orientation and recognition mechanism in the PDE families. The molecular details of the binding pocket observed in this study provide hints for more optimal PDE4 and PDE10 inhibitor design. © 2012 Wiley Periodicals, Inc. Biopolymers 97:910–922, 2012.