bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expression of Insulin-Like Growth Factor II mRNA-Binding Protein 3 in Human Esophageal Adenocarcinoma and Its Precursor Lesions
Authors: Feng Wei , Zhou Zhongren , Peters Jeffrey H , Khoury Thaer , Zhai Qihui , Wei Qiying , Truong Camtu D , Song Sonya Wei , Tan Dongfeng 
Published: September 2011

Context.—Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is an oncofetal protein highly expressed in fetal tissue and malignant tumors but only rarely within adult benign tissues. The expression of IMP3 in esophageal adenocarcinoma (EAC) and its precursor lesions including distinctive type Barrett mucosa (BM, intestinal metaplasia) and esophageal columnar dysplasia (ECD) is largely unknown.
Objective.—To characterize the patterns of IMP3 expression in EAC and its precursor lesions.
Design.—Samples from 132 cases of EAC, 28 cases of ECD (16 high-grade dysplasia and 12 low-grade dysplasia cases), 28 cases of BM without dysplasia, and 138 cases of nonneoplastic esophageal mucosa without dysplasia or BM within formalin-fixed, paraffin-embedded tissue microarray blocks were examined. Tissues were stained with mouse monoclonal anti-IMP3 antibody. The intensity (1–3+) and percent (0%–100%) of positive cytoplasmic and/or membranous IMP3 staining cells were determined.
Results.—Most of EAC cases (93 of 132; 70%) showed cytoplasmic and membranous IMP3 staining. Poorly and moderately differentiated EAC showed statistically significant higher IMP3 expression compared with well-differentiated EAC (P &lt; .001). A subset of ECD cases (7 of 28; 25%) was positive for IMP3, including 3 low-grade dysplasia cases (focal 1+ IMP3 staining) and 4 high-grade dysplasia cases (more diffuse 1–2+ IMP3 staining). No IMP3 staining was observed in any nonneoplastic esophageal mucosa and BM tissues without dysplasia.
Conclusions.—This study suggests that IMP3 may play a role in the carcinogenesis of EAC and has diagnostic utility in differentiating neoplastic and nonneoplastic lesions of the esophagus.
The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma
Authors: Hao Suyang , Smith Thomas W , Chu Peigou G , Liu Qin , Ok Chi Young , Woda Bruce A , Lu Di , Lin Pei , Wang Sa A , Dresser Karen , Rock Kenneth L , Jiang Zhong 
Published: September 2011

Context.—One of the major clinical challenges is to predict recurrence of meningioma. Recently, we have found that IMP3, an oncofetal RNA-binding protein, is a biomarker to predict aggressive tumors.
Objective.—To investigate whether IMP3 can be used as a new biomarker to predict the recurrence and overall survival of patients with meningiomas.
Design.—One hundred seven patients with primary meningiomas were investigated for expression of IMP3 by immunohistochemistry and whether expression of this molecule correlated with tumor recurrence and overall survival.
Results.—Tumor recurrence was found in 13 of 107 patients with primary meningioma. Seven of 107 patients (6.5%) with primary meningiomas expressed IMP3. Kaplan-Meier plots and log-rank tests showed that patients with IMP3-positive tumors had a much higher recurrence rate (P  =  .004) and a poorer overall survival (P &lt; .001) than did patients with IMP3-negative tumors. The 5-year recurrence-free and overall survival rates were 0% and 36% in IMP3-positive patients versus 89% and 94% in IMP3-negative patients, respectively. Multivariable analysis of IMP3 status (positive versus negative) in primary tumors showed a hazard ratio of 17.89 for recurrence (P  =  .01), which was much higher than hazard ratios associated with all other known risk factors including higher tumor grades and Ki-67 labeling index.
Conclusions.—IMP3 is a potential independent prognostic biomarker that can be used at the time of initial diagnosis of meningioma to identify patients who have a high risk of developing a recurrence.
Ruptured Myocardial Abscess Causing Left Ventricle to Pulmonary Artery Communication in an Infant With Community-Associated Methicillin-Resistant Staphylococcus aureus Endocarditis
Authors: Hershenson Jared A , Baker Peter B , Rowland Daniel G 
Published: September 2011

Myocardial abscess perforation is an extremely rare complication of infective endocarditis. We present a case of a 12-month-old infant who developed community-associated methicillin-resistant Staphylococcus aureus bacteremia after an incision and drainage of a skin abscess. He subsequently developed septic emboli to the brain and lungs, and a myocardial cavity in the outlet portion of the interventricular septum. The cavity ruptured 4 days after diagnosis and created a left ventricle to pulmonary artery fistulous communication. The patient died secondary to embolic complications to the brain. We are not aware of any other cases of myocardial abscess rupture in this location of the heart, in a patient of this age, or due to infection with community-associated methicillin-resistant S aureus.
Mislabeling of Cases, Specimens, Blocks, and Slides: A College of American Pathologists Study of 136 Institutions
Authors: Nakhleh Raouf E , Idowu Michael O , Souers Rhona J , Meier Frederick A , Bekeris Leonas G 
Published: September 2011

Context.—Accurate specimen labeling is a major patient-safety initiative by the Joint Commission and the College of American Pathologists. Inadequate specimen labels have led to patient injury from wrong patient diagnosis, wrong side treatment, and delay in diagnosis.Objectives.—To quantify the rates of mislabeled cases, specimens, blocks, and slides and to identify the sources of error and the ways in which errors are detected.Design.—In this voluntary-subscription Q-Probes study, participants prospectively reviewed surgical pathology cases for 8 weeks or until 30 errors (mislabeled cases, specimens, blocks, and slides) were identified. Information collected on each labeling error included the work location where the defect occurred, what was mislabeled, the number of items affected, the point of detection, and the consequences of the mislabeling error, along with institutional demographics and practice. The rates of mislabeled cases, specimens, blocks, and slides were tested for association with institutional demographics and practice variables.Results.—Of the 136 institutions providing information on a total of 1811 mislabeling occurrences, the overall mislabeling rates per 1000 were 1.1 cases, 1.0 specimen, 1.7 blocks, and 1.1 slides. Of all mislabeling events, 27.1% were cases, 19.8% specimens, 25.5% blocks, and 27.7% slides. The work locations at which the errors occurred were 20.9% before accessioning, 12.4% at accessioning, 21.7% at block labeling, 10.2% during gross pathology, and 30.4% at tissue cutting. Errors were typically detected in the first or second steps immediately following the error. Lower mislabeled slide rates were associated with continuous individual case accessioning and use of formal checks at accessioning. Routinely including a statement in the gross description that the specimen is labeled with the patient's name and is properly identified was also associated with lower rates of specimen mislabeling. The errors were corrected before reports were issued 96.7% of the time; for 3.2% of errors, a corrected report was issued. In 1.3% of error occurrences, participants gauged that patient care was affected.Conclusions.—This study quantified mislabeling rates across 136 institutions of cases (0.11%), specimens (0.1%), blocks (0.17%), and slides (0.11%). Errors in labeling appear nearly equally throughout the system of accessioning, gross pathology processing, and tissue cutting. Errors are typically detected in the immediate steps after the errors occurred, reinforcing the need for quality checks throughout the system.
The Effect of Ketone Defects on the Charge Transport and Charge Recombination in Polyfluorenes
Authors: Kuik Martijn , Wetzelaer Gert‐Jan A. H. , Laddé Jurre G. , Nicolai Herman T. , Wildeman Jurjen , Sweelssen Jörgen , Blom Paul W. M. 
Published: September 2011

AbstractThe effect of on‐chain ketone defects on the charge transport of the polyfluorene derivative poly(9,9‐dioctylfluorene) (PFO) is investigated. Using MoO3 as ohmic hole contact, the hole transport in a pristine PFO diode is observed to be limited by space‐charge, whereas fluorenone contaminated PFO (PFO‐F) is shown to be trap limited by the occurrence of an exponential trap distribution with a trap depth of 0.18 eV. The electron transport in PFO is also observed to be trap limited, but in order to describe the electron transport of PFO‐F, an additional trap level with a depth of 0.46 eV must be introduced. The obtained energy levels of the fluorenone trapping sites are in close agreement with cyclic voltammetry (CV) measurements reported in literature. As a result, the fluorenone defects are shown to simultaneously act as hole‐ and electron trap. Moreover, through ideality factor measurements, the green emission associated with these defects is observed to originate from trap‐assisted recombination.
Preparation of guar gum bonded with β‐cyclodextrin microspheres and the absorption on basic fuchsine
Authors: Zhang Xiuju , Zheng Shaojie , Lin Zhidan , Tan Shaozao 
Published: September 2011

Abstractβ‐Cyclodextrin microspheres (β‐CDMs) were prepared and then bonded to guar gum (GG). The structures of the precursor material and product were characterized by X‐ray diffraction and Fourier transform infrared spectroscopy. Phenolphthalein and spectrophotometry were used to determine the content of β‐cyclodextrin (β‐CD) in products. By changing environmental conditions and types of adsorbents, the adsorption capacities of polymers on basic fuchsine were studied. The results indicate that the absorption capacity was decreased accordingly when the pH value was reduced. The increase of temperature had no obvious influence on improving the absorption capacity from 40 to 60°C. When the mass ratio of chloropropyl hydroxyl GG to β‐CDMs to sodium carbonate was 0.6 : 0.8 : 1.0, with the reaction time of 2 h, the best adsorption capacity of 24 mg/g was achieved; this was in accordance with the results of the measurement of the content of β‐CD in the products. The higher content of β‐CDM was beneficial for improving the absorption capacity. By comparing its properties with the absorption capacity of traditional flocculating agents polyacrylamide and polaluminum chloride, the best absorption results for GG bonded with β‐CDMs were obtained. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Application of polysaccharide hydrogels in adsorption and controlled‐extended release of fertilizers processes
Authors: Bortolin Adriel , Aouada Fauze A. , de Moura Márcia R. , Ribeiro Caue , Longo Elson , Mattoso Luiz H. C. 
Published: September 2011

AbstractThis article studied the applicability of poly(acrylamide) and methylcellulose (PAAm‐MC) hydrogels as potential delivery vehicle for the controlled‐extended release of ammonium sulfate (NH4)2SO4 and potassium phosphate (KH2PO4) fertilizers. PAAm‐MC hydrogels with different acrylamide (AAm) and MC concentrations were prepared by a free radical polymerization method. The adsorption and desorption kinetics of fertilizers were determined using conductivity measurements based on previously built analytical curve. The addition of MC in the PAAm chains increased the quantities of (NH4)2SO4 and KH2PO4 loaded and extended the time and quantities of fertilizers released. Coherently, both loading and releasing processes were strongly influenced by hydrophilic properties of hydrogels (AAm/MC mass proportion). The best sorption (124.0 mg KH2PO4/g hydrogel and 58.0 mg (NH4)2SO4/g hydrogel) and desorption (54.9 mg KH2PO4/g hydrogel and 49.5 mg (NH4)2SO4/g hydrogel) properties were observed for 6.0% AAm–1.0% MC hydrogels (AAm/MC mass proportion equal 6), indicating that these hydrogels are potentially viable to be used in controlled‐extended release of fertilizers systems. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Metal‐Organic Niccolite: Synthesis, Structures, Phase Transition, and Magnetic Properties of [CH3NH2(CH2)2NH2CH3][M2(HCOO)6] (M=divalent Mn, Fe, Co, Ni, Cu and Zn)
Authors: Li Meng‐Yuan , Kurmoo Mohamedally , Wang Zhe‐Ming , Gao Song 
Published: September 2011

AbstractWe report the synthesis, crystal structures, thermal and magnetic characterizations of a family of metal‐organic frameworks adopting the niccolite (NiAs) structure, [dmenH22+][M2(HCOO)62−] (dmen=N,N′‐dimethylethylenediamine; M=divalent Mn, 1Mn; Fe, 2Fe; Co, 3Co; Ni, 4Ni; Cu, 5Cu; and Zn, 6Zn). The compounds could be synthesized by either a diffusion method or directly mixing reactants in methanol or methanol–water mixed solvents. The five members, 1Mn, 2Fe, 3Co, 4Ni, and 6Zn are isostructural and crystallize in the trigonal space group P$\bar 3$1c, while 5Cu crystallizes in C2/c. In the structures, the octahedrally coordinated metal ions are connected by anti–anti formate bridges, thus forming the anionic NiAs‐type frameworks of [M2(HCOO)62−], with dmenH22+ located in the cavities of the frameworks. Owing to the Jahn–Teller effect of the Cu2+ ion, the 3D framework of 5Cu consists of zigzag Cu‐formate chains with CuOCHOCu connections through short basal CuO bonds, further linked by the long axial CuO bonds. 6Zn exhibits a phase transition probably as a result of the order–disorder transition of the dmenH22+ cation around 300 K, confirmed by differential scanning calorimetry and single crystal X‐ray diffraction patterns under different temperatures. Magnetic investigation reveals that the four magnetic members, 1Mn, 2Fe, 3Co, and 4Ni, display spin‐canted antiferromagnetism, with a Néel temperature of 8.6 K, 19.8 K, 16.4 K, and 33.7 K, respectively. The Mn, Fe, and Ni members show spin‐flop transitions below 50 kOe. 2Fe possesses a large hysteresis loop with a large coercive field of 10.8 kOe. The Cu member, 5Cu, shows overall antiferromagnetism (both inter‐ and intra‐chains) with low‐dimensional characteristics.
Face recognition performance of individuals with Asperger syndrome on the Cambridge face memory test
Authors: Hedley Darren , Brewer Neil , Young Robyn 
Published: September 2011

AbstractAlthough face recognition deficits in individuals with Autism Spectrum Disorder (ASD), including Asperger syndrome (AS), are widely acknowledged, the empirical evidence is mixed. This in part reflects the failure to use standardized and psychometrically sound tests. We contrasted standardized face recognition scores on the Cambridge Face Memory Test (CFMT) for 34 individuals with AS with those for 42, IQ‐matched non‐ASD individuals, and age‐standardized scores from a large Australian cohort. We also examined the influence of IQ, autistic traits, and negative affect on face recognition performance. Overall, participants with AS performed significantly worse on the CFMT than the non‐ASD participants and when evaluated against standardized test norms. However, while 24% of participants with AS presented with severe face recognition impairment (>2 SDs below the mean), many individuals performed at or above the typical level for their age: 53% scored within +/− 1 SD of the mean and 9% demonstrated superior performance (>1 SD above the mean). Regression analysis provided no evidence that IQ, autistic traits, or negative affect significantly influenced face recognition: diagnostic group membership was the only significant predictor of face recognition performance. In sum, face recognition performance in ASD is on a continuum, but with average levels significantly below non‐ASD levels of performance. Autism Res 2011,4:449–455. © 2011 International Society for Autism Research, Wiley Periodicals, Inc.
Pyrene‐Containing Peptide‐Based Fluorescent Organogels: Inclusion of Graphene into the Organogel
Authors: Adhikari Bimalendu , Nanda Jayanta , Banerjee Arindam 
Published: September 2011

AbstractThe N‐terminally pyrene‐conjugated oligopeptide, Py‐Phe‐Phe‐Ala‐OMe, (Py=pyrene 1‐butyryl acyl) forms transparent, stable, supramolecular fluorescent organogels in various organic solvents. One of these organogels was thoroughly studied using various techniques including transmission electron microscopy (TEM), field‐emission scanning electron microscopy (FESEM), atomic force microscopy (AFM), Fourier‐transform infrared (FTIR) spectroscopy, photolumininiscence (PL) spectroscopy, and rheology. Unfunctionalized and non‐oxidized graphene was successfully incorporated into this fluorescent organogel in o‐dichlorobenzene (ODCB) to form a stable hybrid organogel. Graphene is well dispersed into the gel medium by using non‐covalent π–π stacking interactions with the pyrene‐conjugated gelator peptide. In the presence of graphene, the minimum gelation concentration (mgc) of the hybrid organogel was lowered significantly. This suggests that there is a favorable interaction between the graphene and the gelator peptide within the hybrid organogel system. This hybrid organogel was characterized using TEM, AFM, FTIR, PL, and rheological studies. The TEM study of graphene‐containing hybrid organogel revealed the presence of both graphene sheets and entangled gel nanofibers. The AFM study indicated the presence of 3 to 4 layers in exfoliated graphene in ODCB and the presence of both graphene nanosheets and the network of gel nanofibers in the hybrid gel system. The rheological investigation suggested that the flow of the hybrid organogel had become more resistant towards the applied angular frequency upon the incorporation of graphene into the organogel. The hybrid gel is about seven times more rigid than that of the native gel.
In Situ Phosphine Oxide Reduction: A Catalytic Appel Reaction
Authors: van Kalkeren Henri A. , Leenders Stefan H. A. M. , Hommersom C. Rianne A. , Rutjes Floris P. J. T. , van Delft Floris L. 
Published: September 2011

AbstractSeveral important reactions in organic chemistry thrive on stoichiometric formation of phosphine oxides from phosphines. To avoid the resulting burden of waste and purification, cyclic phosphine oxides were evaluated for new catalytic reactions based on in situ regeneration. First, the ease of silane‐mediated reduction of a range of cyclic phosphine oxides was explored. In addition, the compatibility of silanes with electrophilic halogen donors was determined for application in a catalytic Appel reaction based on in situ reduction of dibenzophosphole oxide. Under optimized conditions, alcohols were effectively converted to bromides or chlorides, thereby showing the relevance of new catalyst development and paving the way for broader application of organophosphorus catalysis by in situ reduction protocols.
Extramedullary intracranial localization of multiple myeloma and treatment with novel agents: A retrospective survey of 50 patients
Authors: Gozzetti Alessandro , Cerase Alfonso , Lotti Flavia , Rossi Davide , Palumbo Antonio , Petrucci Maria Teresa , Patriarca Francesca , Nozzoli Chiara , Cavo Michele , Offidani Massimo , Floridia Michele , Berretta Salvatore , Vallone Roberto , Musto Pellegrino , Lauria Francesco ,   for the GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto) Myeloma Working Party
Published: September 2011

AbstractBACKGROUND:Intracranial involvement in multiple myeloma is extremely rare. The effect of new drugs (eg, thalidomide, bortezomib, lenalidomide) with respect to old drugs (eg, alkylators, steroids) has not been reported.METHODS:We collected clinical and biological data of patients presenting with an osteo‐dural or primary dural multiple myeloma (OD‐DMM) or a central nervous system myelomatosis (CNS‐MM) by sending a questionnaire to the centers of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA).RESULTS:A total of 50 patients were registered. New therapies were used in 35 patients, whereas 15 patients received old treatments. Twenty‐five out of 50 patients obtained a complete remission or a very good partial remission (CR+VGPR). Overall survival (OS) for CNS‐MM was 6 months, for OD‐DMM 25 months. OS was 25 months for patients treated with new agents versus 8 months with old agents. Improved OS and progression‐free survival were predicted by response (CR+VGPR) and by patients who underwent stem cell transplantation versus chemotherapy. β2‐Microglobulin >5 mmol/L was a poor prognostic factor. Multivariate analysis showed poor survival for patients with β2‐microglobulin >5 mmol/L and better survival for patients achieving CR+VGPR.CONCLUSIONS:The overall data highlight the relevance of therapy with new drugs in intracranial myeloma, providing a framework for future clinical trials. Cancer 2011;. © 2011 American Cancer Society.
Predicting pulmonary adenocarcinoma outcome based on a cytology grading system
Authors: Sigel Carlie S. , Rudomina Dorota E. , Sima Camelia S. , Rekhtman Natasha , Travis William D. , Geisinger Kim R. , Moreira Andre L. 
Published: September 2011

AbstractBACKGROUND:Pulmonary adenocarcinoma (AD) has a variety of architectural patterns. Recently, a 3‐tiered histological pattern‐based grading system was developed for stage I lung AD, stratifying patients into low, intermediate, and high risk for recurrence. However, cytology may serve as the primary method for diagnosis in patients with inoperable disease. Attempts to correlate architecture between parallel cytological and histological preparations have not been successful. Therefore, we evaluated cytomorphologic features of previously histologically graded AD to identify features of potential prognostic significance.METHODS:One hundred and thirteen fine‐needle aspirations with excised adenocarcinomas were reviewed. In the liquid‐based preparation, we evaluated cell arrangements (flat sheets vs 3‐D clusters vs single cells), nuclear features (size variability, shape, and contour), nucleoli (prominent or inconspicuous), presence of nuclear inclusions, chromatin (fine, coarse, or clumped), and quality of background. The features were tested by multivariate analysis to identify associations with histological grade and disease‐free survival (DFS), and a cytological score was generated.RESULTS:Nuclear size, chromatin pattern, and nuclear contours showed a significant association with histological grade and DFS. These features were included in the composite cytological score (range, 0‐5). By grouping the cytological scores, we stratified the tumors into low (median DFS, 100%), intermediate (median DFS, 78%), and high (median DFS, 55%) rate of recurrence (P = .008). There was a good correlation with the histological grading system.CONCLUSIONS:In liquid‐based preparations, distinctive cytological features of pulmonary adenocarcinoma correlate with levels of histological differentiation and can be combined into a score with prognostic significance. Cancer (Cancer Cytopathol) 2012. © 2011 American Cancer Society.