bluuebunny/crossref_metadata_2025_split huggingface dataset:
CD4+CD57+ senescent T cells as promoters of systemic lupus erythematosus pathogenesis and the therapeutic potential of senolytic BCL‐2 inhibitor
Authors: Jiang Jiao , Yang Ming , Zhu Huan , Long Di , He Zhenghao , Liu Juan , He Liting , Tan Yixin , Akbar Arne N. , Reddy Venkat , Zhao Ming , Long Hai , Wu Haijing , Lu Qianjin 
Published: May 2024

AbstractSystemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by persistent activation of immune cells and overproduction of autoantibodies. The accumulation of senescent T and B cells has been observed in SLE and other immune‐mediated diseases. However, the exact mechanistic pathways contributing to this process in SLE remain incompletely understood. In this study, we found that in SLE patients: (1) the frequency of CD4+CD57+ senescent T cells was significantly elevated and positively correlated with disease activity; (2) the expression levels of B‐lymphoma‐2 (BCL‐2) family and interferon‐induced genes (ISGs) were significantly upregulated; and (3) in vitro, the cytokine IL‐15 stimulation increased the frequency of senescent CD4+ T cells and upregulated the expression of BCL‐2 family and ISGs. Further, treatment with ABT‐263 (a senolytic BCL‐2 inhibitor) in MRL/lpr mice resulted in decreased: (1) frequency of CD4+CD44hiCD62L−PD‐1+CD153+ senescent CD4+ T cells; (2) frequency of CD19+CD11c+T‐bet+ age‐related B cells; (3) level of serum antinuclear antibody; (4) proteinuria; (5) frequency of Tfh cells; and (6) renal histopathological abnormalities. Collectively, these results indicated a dominant role for CD4+CD57+ senescent CD4+ T cells in the pathogenesis of SLE and senolytic BCL‐2 inhibitor ABT‐263 may be the potential treatment in ameliorating lupus phenotypes.
Bis(ferrocenyl)stannylene
Authors: Iijima Keisuke , Sugamata Koh , Majhi Paresh Kumar , Sasamori Takahiro 
Published: May 2024

AbstractA bis(ferrocenyl)stannylene, whose ferrocenyl ligands contain sterically demanding substituents, Fc*2Sn (1; Fc*=2,5‐bis(3,5‐di‐t‐butylphenyl)‐1‐ferrocenyl), has been synthesized as a monomeric diorganostannylene. Stannylene 1 undergoes a ligand‐redistribution reaction with SnCl2 to give the corresponding chloro(ferrocenyl)stannylene, Fc*(Cl)Sn:.
Credibility, readability and content analysis of treatment recommendations for adolescents with nonspecific back pain published on consumer websites
Authors: Hauber S. D. , Robinson K. , Fechner R. , Pate J. W. , O'Sullivan K. 
Published: May 2024

AbstractBackgroundParents may seek out health information online when their adolescent has nonspecific back pain to better understand treatment options. Such information directed towards consumers has not been previously analysed.MethodsA descriptive cross‐sectional content analysis was performed to describe the treatments recommended on consumer websites for nonspecific back pain in adolescents. The credibility and readability of the websites were also assessed. Systematic Google searches were completed in five countries, and relevant content from eligible web pages was analysed. An a priori codebook with 34 treatment‐related codes was developed. Nine additional codes were inductively created during analysis. Credibility was assessed using the JAMA benchmark. Readability was assessed via the Flesch Kincaid Grade Level.ResultsOf 245 web pages, 48 were deemed eligible and analysed. Of 43 treatment codes, 37 were present in at least one web page. The five most frequently identified codes were See the doctor/get a diagnosis (found on 85% of web pages), Ergonomics/posture/biomechanics (52%), Reassurance (48%), Physiotherapy (48%) and Non‐prescription pharmaceuticals/supplements (46%). Only 21% of the web pages met all four JAMA benchmark criteria, and 15% cited at least one recent or high‐quality source. The median Flesch Kincaid Grade Level score was 9.0 (range 3.5–12.9).ConclusionsParents of adolescents with nonspecific back pain may find that treatment recommendations published online are numerous and varied, with visits to the doctor encouraged. The credibility scores of these web pages are generally low, while the median reading level may be too high for the general population.Significance StatementThis analysis reveals that public‐facing websites with recommendations for treating adolescent nonspecific back pain do not cite the most recent, high‐quality research. Although web pages correctly encourage physical activity and exercise over surgery and prescription medications, they do not reflect the psychologically informed or interdisciplinary care emphasized in recently published treatment recommendations. Clinicians must be aware that caregivers of their adolescent patients with nonspecific back pain may be exposed to online messages that encourage them to keep seeking a diagnosis.
Use of chia (Salvia hispanica L.) seed mucilage powder as a stabilizer in the preparation of salep beverage
Authors: Altaş Alev , Gursoy Oguz , Güler Dal Hande Özge , Yilmaz Yusuf 
Published: May 2024

AbstractSalep, a traditional Turkish beverage, derives its name from its primary component: salep powder (SP), which is sourced from the tubers of certain orchid species. This study investigated various physicochemical attributes (including dry matter, protein content, pH, titration acidity, water activity, color, serum separation, and zeta potential), as well as rheological and sensory characteristics of salep beverages. These drinks were prepared by substituting SP with chia (Salvia hispanica L.) seed mucilage powder (MP) with different ratios (10%, 20%, 30%, and 40%). The substitution of SP with MP did not influence the dry matter and protein contents or the pH and acidity values of the drinks significantly (p > .05). The inclusion of MP in the formulation of salep drinks resulted in a decrease in lightness (L*) and a* color values while increasing the b* color values. However, consumer perception, as indicated by color difference values (∆E*), showed no distinguishable difference between drinks containing MP and control drinks. Furthermore, higher ratios of MP led to increased apparent viscosity values in the drinks and effectively prevented or significantly reduced serum separation observed in control drinks (p < .05). Remarkably, sensory evaluations revealed that substituting up to 30% of SP with MP did not negatively impact the overall sensory properties of the drinks (p > .05), suggesting that MP could be recommended as a feasible alternative. This substitution has the potential to contribute to the conservation of orchid plants, the primary source of salep, while also offering cost‐saving benefits in the production of salep drinks.
Pediatric colonic adenocarcinoma: A deceptive case of gastroenteritis and constipation
Authors: Hachem Jack J. , Javadi Sara , McKee Milissa , Noel James , Noel Robert A. 
Published: May 2024

AbstractAdenocarcinoma of the colon is a rare diagnosis in pediatric patients. We present a previously healthy 15‐year‐old female who began experiencing escalating colicky abdominal pain and associated vomiting over 2 weeks in the setting of presumed acute gastroenteritis. A computed tomography scan revealed an obstruction in her descending colon. A multidisciplinary decision was made to perform a colonoscopy upon which a large, circumferential, friable lesion was discovered 40 cm from the anus. A colon decompression catheter was successfully inserted following controlled radial expansion (CRE) Balloon dilation to 13.5 mm beyond the mass, resulting in a significant discharge of fluid and gas. The patient underwent hemicolectomy with mass resection and colostomy. Biopsies confirmed poorly differentiated adenocarcinoma with “napkin‐ring” morphology and positive lymph node metastasis with extranodal extension.
Preoperative glycaemic control, number of pain locations, structural knee damage, self‐reported central sensitisation, satisfaction and personal control are predictive of 1‐year postoperative pain, and change in pain from pre‐ to 1‐year posttotal knee arthroplasty
Authors: Vervullens Sophie , Meert Lotte , Smeets Rob J. E. M. , Verbrugghe Jonas , Baert Isabel , Rahusen Frank Th. G. , Heusdens Christiaan H. W. , Verdonk Peter , Meeus Mira 
Published: May 2024

AbstractPurposeThe aim of this study was to identify preoperative predictors for 1‐year posttotal knee arthroplasty (TKA) pain and pre‐ to post‐TKA pain difference in knee osteoarthritis (KOA) patients.MethodsFrom March 2018 to July 2023, this prospective longitudinal cohort study enrolled KOA patients awaiting TKA from four hospitals in Belgium and the Netherlands. Different biopsychosocial predictors were assessed preoperatively by questionnaires and physical examinations (input variables). The Knee injury and Osteoarthritis Outcome Score (KOOS) subscale pain was used to measure pain intensity. The absolute KOOS subscale pain score 1‐year post‐TKA and the difference score (ΔKOOS = 1‐year postoperative − preoperative) were used as primary outcome measures (output variables). Two multivariable linear regression analyses were performed.ResultsTwo hundred and twenty‐three participants were included after multiple imputation. Worse absolute KOOS subscale pain scores 1‐year post‐TKA and negative or closer to zero ΔKOOS subscale pain scores were predicted by self‐reported central sensitisation, lower KOA grade and preoperative satisfaction, and higher glycated haemoglobin, number of pain locations and personal control (adjusted R2 = 0.25). Additional predictors of negative or closer to zero ΔKOOS subscale pain scores were being self‐employed, higher preoperative pain and function (adjusted R2 = 0.37).ConclusionThis study reports different biopsychosocial predictors for both outcomes that have filtered out other potential predictors and provide value for future studies on developing risk assessment tools for the prediction of chronic TKA pain.Protocol RegistrationThe protocol is registered at clinicaltrials.gov (NCT05380648) on 13 May 2022.Level of EvidenceLevel II.
Liver fibrosis automatic diagnosis utilizing dense‐fusion attention contrastive learning network
Authors: Guo Yuhui , Li Tongtong , Zhao Ziyang , Sun Qi , Chen Miao , Jiang Yanli , Yao Zhijun , Hu Bin 
Published: May 2024

AbstractBackgroundLiver fibrosis poses a significant public health challenge given its elevated incidence and associated mortality rates. Diffusion‐Weighted Imaging (DWI) serves as a non‐invasive diagnostic tool for supporting the identification of liver fibrosis. Deep learning, as a computer‐aided diagnostic technology, can assist in recognizing the stage of liver fibrosis by extracting abstract features from DWI images. However, gathering samples is often challenging, posing a common dilemma in previous research. Moreover, previous studies frequently overlooked the cross‐comparison information and latent connections among different DWI parameters. Thus, it is becoming a challenge to identify effective DWI parameters and dig potential features from multiple categories in a dataset with limited samples.PurposeA self‐defined Multi‐view Contrastive Learning Network is developed to automatically classify multi‐parameter DWI images and explore synergies between different DWI parameters.MethodsA Dense‐fusion Attention Contrastive Learning Network (DACLN) is designed and used to recognize DWI images. Concretely, a multi‐view contrastive learning framework is constructed to train and extract features from raw multi‐parameter DWI. Besides, a Dense‐fusion module is designed to integrate feature and output predicted labels.ResultsWe evaluated the performance of the proposed model on a set of real clinical data and analyzed the interpretability by Grad‐CAM and annotation analysis, achieving average scores of 0.8825, 0.8702, 0.8933, 0.8727, and 0.8779 for accuracy, precision, recall, specificity and F‐1 score. Of note, the experimental results revealed that IVIM‐f, CTRW‐β, and MONO‐ADC exhibited significant recognition ability and complementarity.ConclusionOur method achieves competitive accuracy in liver fibrosis diagnosis using the limited multi‐parameter DWI dataset and finds three types of DWI parameters with high sensitivity for diagnosing liver fibrosis, which suggests potential directions for future research.
A novel predictive optimal control strategy for renewable penetrated interconnected power system
Authors: Kumar Vineet , Sharma Veena , Naresh Ram , Arya Yogendra 
Published: May 2024

AbstractThe stable and efficient regulation of voltage and frequency is a critical issue associated with the functioning of modern power system network having renewable integration. This manuscript focuses on the concurrent regulation of voltage and frequency in a power network comprising multiple generating sources. Herein, along with conventional thermal and diesel plants, renewable generations from different sources have been considered such as wind and solar photovoltaic (PV) resources. Further, in a fresh attempt, the authors have modeled wind and solar PV generation using two different stochastic modeling methods concerning combined voltage and frequency loops in the regulated power system model. Furthermore, the novel Leader Harris Hawks Optimized Model Predictive Controller (MPC‐LHHO) has been applied to concurrently minimize the voltage and frequency deviations in the given power network. To address the intermittent nature of load and renewable generations, various auxiliary frequency controllers, such as the unified power flow controller (UPFC) and electric vehicle (EV) integration with the grid, have been implemented. The robustness of the proposed control method has been successfully validated through diverse scenarios of random loadings.
Effects of fiber characteristics on tensile and impact properties of long fiber reinforced High‐Density Polyethylene
Authors: Jiang Lijuan , Wang Xin , Zhou Yinzhi 
Published: May 2024

AbstractDue to the requirements of high stiffness and impact strength of HDPE pipes, in this article, long fiber reinforced HDPE were developed and the effects of fiber length, volume fraction, types, and matrix/fiber interface on the mechanical properties were investigated. Tensile properties, notched impact strength, as well as microstructures were tested. The results showed that fibers increased the tensile strength, modulus, and impact strength, but decreased their plastic deformation. Larger fiber fraction indicates more fibers are involved in load bearing, but easy agglomeration. With ascending fiber length, tensile, and impact strength first increased and then decreased, whereas tensile modulus first increased and then maintained an almost constant value. Carbon fibers showed no advantages over glass fibers and basalt fibers in reinforcing HDPE due to the relatively poor interface bonding strength. Interface modification with KH550 improved the mechanical performance of composites, but the enhancement was limited. More effective methods should be developed for better performance.Highlights
Fiber increases strength and modulus, but decreases plastic deformation.
Critical fiber length for basalt LFT is 2.6 mm obtained from SEM.
Larger fiber volume and length lead to agglomerations.
Difference in BF, CF, and GF reinforced HDPE is determined by interface.
Interface modification enhances mechanical properties of LFT but limited.
Fetal cardiac teratoma and pericardiocentesis: A case report
Authors: Gupta Neha , Dash Pratima , Marwah Ashutosh 
Published: May 2024

AbstractFetal pericardial teratomas are rare. They present with pericardial effusion and hydrops. The definitive management is postnatal resection of the tumor. The exact antenatal management is not known due to its rarity. We present a case of fetal pericardial teratoma with pericardial tamponade. Pericardiocentesis performed at 31 weeks significantly relieved the venous compression, leading to resolution of hydrops and prolonging the gestational age for the definitive management.
Non‐Markovian Cost Function for Quantum Error Mitigation
Authors: Ahn Doyeol , Park Byeongyong 
Published: May 2024

AbstractIn near‐term quantum computers like noisy intermediate‐scale quantum (NISQ) devices, reducing the impact of errors and decoherence is critical for practical implementation. Existing studies have primarily focused on Markovian noise sources; however, understanding the relationship between quantum error mitigation (QEM) and non‐Markovian noise sources is essential, as these effects are practically unavoidable in most solid‐state devices used for quantum computing. Here, a non‐Markovian model of quantum state evolution and a QEM cost function of controlled‐NOT (CNOT) gate operation are presented for NISQ devices interacting with an environment characterized by simple harmonic oscillators as a noise source. Using the projection operator formalism and both advanced and retarded propagators in time, the reduced‐density operator is derived for output quantum states in a time‐convolutionless form by solving the quantum Liouville equation. Output quantum state fluctuations are analyzed for identity and CNOT gate operations in two‐qubit operations across various input states and compare these results with experimental data from ion‐trap and superconducting quantum computing systems to estimate the key parameters of the QEM cost functions. These findings demonstrate that the QEM cost function increases as the coupling strength between the quantum system and its environment intensifies. This study highlights the significance of non‐Markovian models for understanding quantum state evolution and the practical implications of the QEM cost function in assessing experimental results from NISQ devices.
Endobronchial ultrasound‐guided cryobiopsy for diagnosing a case of granulomatosis with polyangiitis
Authors: Calari Teresa , Petrarulo Simone , Dubini Alessandra , Piciucchi Sara , Ravaglia Claudia , Poletti Venerino 
Published: May 2024

AbstractEBUS‐TBNA has represented a revolution in the diagnosis of intrathoracic pathologies, particularly in lung cancer staging, replacing more invasive methods such as mediastinoscopy. However, its role in diagnosing rare benign or malignant mediastinal disorders is still a matter of debate. Over the past few years, the role of EBUS‐guided cryobiopsy has been increasingly emerging as an innovative and minimally invasive technique in diagnosing these disorders, with an excellent safety profile. In this case report, we present the case of a young man brought to our attention after already undergoing a non‐diagnostic trans thoracic needle aspiration (TTNA) procedure for lung consolidations. In our department, he underwent an initial EBUS‐TBNA procedure with inconclusive rapid on‐site evaluation (ROSE), leading to the decision to perform an EBUS‐guided cryobiopsy, which yielded a diagnosis of granulomatosis with polyangiitis without complications. This clinical case demonstrates that in specific contexts, EBUS‐cryobiopsy represents an excellent diagnostic tool.
Developing model‐based storytelling to share systemic insights to the public during the COVID‐19 pandemic
Authors: Gordon Daniel , Mashayekhi Ali N. , Tomoaia‐Cotisel Andrada , Kim Hyunjung , Bahaddin Babak , Luna‐Reyes Luis F. , Andersen David F. 
Published: May 2024

AbstractCommunicating dynamic insights to a wide audience constitutes a long‐standing challenge among system dynamics modelers. We propose that telling stories is a compelling way of introducing feedback insights, as well as an understanding of how our individual decisions are linked to social behaviors in our day‐to‐day living. These decisions often involve moral and ethical trade‐offs. In this article, we use examples and heuristics to illustrate how the process of building a system dynamics model can drive a storytelling project. In a complimentary manner, the process of storytelling supports and enriches a model building project by exploring new dynamic hypotheses. © 2024 The Authors. System Dynamics Review published by John Wiley & Sons Ltd on behalf of System Dynamics Society.
A Novel Fluorescent Probe containing dihydropyrimidinone Analogue for Highly Sensitive, Selective Detection of Al(III) Ions with its Molecular Docking, ADME/T and Anticancer Impact
Authors: El‐Nahass Marwa N. , Bakr Eman A. , Hamada Wafaa M. , Fayed Tarek A. , El‐Kemary Maged , Salem Maha M. , Noser Ahmed A. 
Published: May 2024

AbstractIn this investigation, a novel and promising chemosensor incorporating a dihydropyrimidinone moiety, namely; (E)‐4‐(4‐(dimethylamino)phenyl)‐5‐(3‐(4‐(dimethylamino)phenyl)acryloyl)‐6‐methyl‐3,4 dihydropyrimidin‐2(1H)‐one (DPDAD), has been successfully synthesized and characterized. The DPDAD chemosensor‘s response was evaluated in diverse solvents with varying polarities, shedding light on its solvatochromic behavior. The assessment of colorimetric and optical sensing attributes toward a range of metal ions such as Al(III), Cr(III), Mn II), Fe(III), Co(II), Ni(II), and Cu(II) was undertaken. Notably, DPDAD displayed discernible color alterations upon interaction with all the examined metal ions, with a significant bathochromic shift observed in the absorption spectra in the presence of Al(III), distinguishing it from the other metal ions. Furthermore, through detailed absorption and emission spectral analyses, DPDAD exhibited remarkable selectivity, sensitivity, and an on‐off‐on switchable behavior specifically with Al(III) ions, over the other metal ions. The binding constant was determined as 0.39×105 M−1, accompanied by a limit of detection (LOD) of 1.03×10−5 M. Notably, the DPDAD′s potential extends beyond metal ion sensing; it was computationally assessed for its capability to inhibit the γ‐secretase enzyme. Moreover, DPDAD′s antioxidant attributes were probed, and its inhibitory effect against a range of cancer cell lines was verified in‐vitro.
Critical Effects of Insoluble Additives in Liquid Electrolytes for Metal Batteries
Authors: Xu Zhu , Wang Kexuan , Li Heng , Wang Huibo , Ge Mingzheng , Zhang Yanyan , Tang Yuxin , Chen Shi 
Published: May 2024

AbstractRechargeable metal batteries have received widespread attention due to their high energy density by using pure metal as the anode. However, there are still many fundamental problems that need to be solved before approaching practical applications. The critical ones are low charge/discharge current due to slow ion transport, short cycle lifetime due to poor anode/cathode stability, and unsatisfied battery safety. To tackle these problems, various strategies have been suggested. Among them, electrolyte additive is one of the most widely used strategies. Most of the additives currently studied are soluble, but their reliability is questionable, and they can easily affect the electrochemical process, causing unwanted battery performance decline. On the contrary, insoluble additives with excellent chemical stability, high mechanical strength, and dimensional tunability have attracted considerable research exploration recently. However, there is no timely review on insoluble additives in metal batteries yet. This review summarizes various functions of insoluble additives: ion transport modulation, metal anode protection, cathode amelioration, as well as battery safety enhancement. Future research directions and challenges for insoluble solid additives are also proposed. It is expected this review will stimulate inspiration and arouse extensive studies on further improvement in the overall performance of metal batteries.