bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evaluation of Acehnese people's health insurance from the welfare perspectives
Authors: Yani Muhammad , Suhanda Rachmad , Iqbalawati Indrita , Puspandari Diah Ayu , Hafasnuddin  , Candra Aditya , Ilzana Teuku Muhammad , Khaled Teuku Muhammad , Cut Rizka Rahmi  
Published: May 2024

Link of Video Abstract: https://youtu.be/UEJWESqCEvo

Introduction: Indonesia has tried to implement the UHC system by implementing the National Health Insurance (JKN) program since 2014. To extend the coverage of JKN, the government of Aceh, one of the poorest provinces in Indonesia carries out Acehnese People's Health Insurance (JKA), which aims to improve the health and welfare of the people of Aceh. However, there has never been an evaluation of the usefulness of JKA related to the welfare of the Acehnese people. Therefore, this study aims to evaluate the impact of JKA on the level of welfare of the people of Aceh.
Methods: This was an ecological study with a cross-sectional approach to evaluate the correlation between welfare indicators (education, health, and housing) and Community Coverage Levels and Capitation Costs on Acehnese People's Health Insurance. All study data were taken from the Acehnese public health insurance accountability report and the people's welfare statistics report from the Central Statistics Agency. All data collected were analyzed using SPSS ver. 25.
Results: JKA has an average community coverage of about 2 million people with an average capitation payment of around 139 billion rupiahs from 2015 to 2021. Immunization coverage was significantly correlated with community coverage, non-capitation fee, and drug cost. In addition, drug costs are also significantly related to formal school coverage. Meanwhile, medical equipment cost was correlated with sanitation and internet coverage. However, other welfare indicators did not find a correlation between community coverage and capitation costs.
Conclusion: Some indicators of JKA were significantly correlated with several indicators of welfare in Aceh.
Topical nonsteroidal anti-inflammatory drugs in the prevention of pseudophakic cystoid macular edema following phacoemulsification: A systematic review
Authors: Arista Dewi Ni Putu Ayu Pande , Pemayun Cokorda Istri Dewiyani 
Published: May 2024

Introduction: The goal of surgeons to avoid Pseudophakic Cystoid Macular Edema (PCMO) has led to the widespread use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) after cataract surgery, although current research into the best anti-inflammatory drugs to avoid PCMO is still underway. This review aimed to determine the efficacy of topical NSAIDs in preventing PCMO following phacoemulsification.
Methods: This systematic review was built on the recommended reporting items for systematic reviews and meta-analyses (PRISMA) and PICO criteria for papers during the previous 10 years. The keywords was searched by Boolean operator: “NSAIDs” AND “Prevention” AND “Cystoid Macular Edema” AND “Optical Coherence Tomography” AND “Phacoemulsification”. According to STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) checklist, the quality of each chosen article was evaluated.
Results: We have selected five articles of prospective cohort studies, which involved 756 patients whom received topical NSAIDs (Nepafenac 0.3%, Ketorolac Tromethamine 0.4%Nepafenac 0.1%, , and Diclofenac 0.1%) in treatment group and 700 patients received Placebo (Artificial tears) in control group. There was significant difference of central macular thickness based on OCT results between NSAIDs and control (placebo) group after uneventful phacoemulsification. Additionally, NSAIDs used as a preventative before phacoemulsification procedure exhibited a significantly reduced rise in central foveal thickness compared to placebo. There were changes of central macular thicknes postoperatively, and were significantly different from preoperative.
Conclusion: It has been demonstrated that topical NSAIDs successfully lower the incidence of Pseudophakic Cystoid Macular Edema following phacoemulsification.
The comparison of effects of iron supplementation since pre-pregnant and during pregnant period on reducing iron deficiency anemia in pregnant women with mild anemia in Bali
Authors: Ani Luh Seri , I Made Bakta  , Made Ayu Hitapretiwi Suryadhi  , Bagiada Nyoman Agus 
Published: May 2024

Introduction: Iron deficiency anemia (IDA) is still a problem of pregnant women's health related to its high prevalence and its negative effects on health. Prevention efforts have been carried out through administration of oral iron tablets to women during their pregnancy; however, the expected results have not been satisfied yet. This failure is probably due to the assumption that, especially in developing countries, the iron store in pre-pregnant women is very low or may be empty, so that iron supplementation during pregnancy is not enough to prevent IDA. The aim of study is to know the difference of effect of iron supplementation in treated and control groups in terms of hemoglobin concentration, serum ferritin level and prevalence of IDA.
Method: A quasi-experimental study was conducted on 99 non-pregnant new couple women. Iron tablets were administered to the treated group from the beginning of pre-pregnant period, continuing until the first 3 months of pregnancy, while in the control group iron tablets were only given during the first 3 months of pregnancy. IDA was measured by serum ferritin and hemoglobin concentration using WHO’s criteria, the benefit of iron tablet was measured by BCR technique.
Result: The administration of an oral iron tablet from the prepregnant period (treated group) could decrease prevalence of IDA higher than the administration of oral iron tablet during pregnancy only (control group) (0% vs 38.46%, p<0.05). A significant difference was also observed on mean serum ferritin concentration at the end of observation (the third month of pregnancy) 33.45±14.12 µg/dL in the treated group, and 19.65±8.99 µg/dL in the control group. This difference was statistically significant (p<0.05). Meanwhile, the hemoglobin concentration was 12.25±1.20 g/dL in the treated group and 10.91±0.67 g/dL in the control group. This difference was also statistically significant (p<0.05). Benefit analysis showed that administration of an oral iron tablet starting from pre-pregnancy is more advantageous (BCR >1) compared to oral administration of iron tablet during the pregnancy period only. There were no significant differences in side effects and compliance of the patient to consume iron pills in both treated and control groups.
Conclusion: The administration of oral iron tablets (iron supplementation) to pregnant women starting from pre-pregnant period results in a better effect compared to oral iron supplementation during pregnancy only. This program is feasible to be implemented in a community setting because its compliance is good.
The immune response of SARS-CoV-2 vaccine in population with obesity: a systematic review
Authors: Arafah Nur , Soegiarto Gatot , Wulandari Laksmi 
Published: May 2024

Link of Video Abstract: https://youtu.be/rXb-E8We3vU

Background: COVID-19 vaccines involve a humoral response to produce a neutralizing antibody that could protect subjects from severe COVID-19 infection. However, obesity tends to lower the immune response to the COVID-19 vaccine. Therefore, we conducted a systematic review to determine the immune response of various types of COVID-19 vaccines in a population with obesity.
Methods: We conducted a systematic review based on The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement. Using keywords, we search studies from Taylor & Francis, PubMed, ScienceDirect, Cochrane, and EBSCOHost.
Results: We included eight cohort studies with 21,280 subjects after thorough selection and appraisal. Four studies stated that obesity was related to lower antibody titer post-SARS-CoV-2 vaccination, even though one study stated that obesity was not associated with long-term immune response. Another prospective cohort study involving approximately nine million populations stated that SARS-CoV-2 vaccination provided similar protection against COVID-19 compared to normoweight when underweight was a risk factor for lower protection. One study found that antibody titer wanes faster in obesity compared to normoweight. In addition, another study found lower antibody titer in obese men, whereas no significant findings were found in obese women.
Conclusion: Therefore, it should be noted that COVID-19 vaccination in an obese population tends to provide a lower immune response regardless of vaccine type and doses are given. This should inform clinicians who want to administer the COVID-19 vaccine to obese populations.
Profile of tracheotomy patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia
Authors: Amalia Siska Citra , Romdhoni Achmad Chusnu 
Published: May 2024

Link of Video Abstract: https://youtu.be/YsAWA4NoiPw

Background: The tracheotomy profile, including the degree of airway obstruction, underlying disease, following procedures, and complications, is important. The latest data regarding the profile of tracheotomy patients at ORL-HNS Dr. Soetomo General Academic Hospital has not been published yet. This research to describe the profile of tracheotomy patients at ORL-HNS Department Dr. Soetomo General Academic Hospital, Surabaya
Methods: A retrospective descriptive study with total sampling covering tracheotomy patients in 2015-1019 at ORL-HNS Department Dr. Soetomo General Academic Hospital, Surabaya. Data were analyzed using SPSS version 23.0 for Windows.
Result: There were 590 tracheotomy patients consisting of 452 men and 138 women, with the largest age group of 51-60 years with 167 patients (28.31%). Jackson 1 in 306 (51.86%), impending upper airway obstruction in 209 (35.42%), Jackson 2 in 38 (6.44%), Jackson 3 in 31 patients (5.25%), Jackson 4 in 3 patients (0.51%). The diagnosis includes tumors (87.29%), especially laryngeal carcinoma, then infection, neurological, trauma, and others. Procedures following tracheotomy are biopsies (11.19%), tumor surgery, and abscess incision and drainage. Complications were found in 65 patients (11.02%). Subcutaneous emphysema in 45 patients (7.63%), followed by bleeding and pneumothorax with subcutaneous emphysema (1.02%), 5 died (0.85%). Subcutaneous emphysema and bleeding in 2 patients (0.34%). Pneumothorax without subcutaneous emphysema in 1 patient (0.17%).
Conclusions: There were more male tracheotomy patients than female. The age group of most patients was 51-60 years. The majority were Jackson 1, and most were diagnosed with tumors. A biopsy is the most following procedure in tracheotomy. Complications were found in 11.02% of tracheotomy patients; the most common is subcutaneous emphysema.
Effect of probiotics as adjuvant therapy of antidepressants in male Wistar rats with anhedonia behavior
Authors: Evilia Wati , Wahyuni Anak Ayu Sri , Ida Aju Kusuma Wardani  , Putra I Wayan Gede Artawan Eka , Lely Setyawati Kurniawan  , Diniari Ni Ketut Sri , Ardani I Gusti Ayu Indah , Arijana I Gusti Kamasan Nyoman 
Published: May 2024

Link of Video Abstract : https://youtu.be/umLlj1K4l2w

Background: Depression is one of the most common causes of disability in the world, and one third of patients do not respond to currently available antidepressants, so a strategy is needed in its management. There have been many studies looking for a relationship between the role of the gut and mental health. Probiotics are the focus of much research in the field of psychiatry today due to their alleged role in improving mental health through gut health.
Methods: This research was a true experimental study with a posttest-only design with a control group design. Brain-derived neurotrophic factor (BDNF) plasma levels, serum serotonin (ST) serum levels, and sucrose preference test (SPT) values were analysed in 39 male Wistar rats with anhedonic behavior.
Results: Average BDNF plasma level in treatment group was 1.63 ng/mL with a standard deviation of 0.56 ng/mL, while the mean BDNF plasma level in control group was 0.89 ng/mL with a standard deviation of 0.46 ng/mL. There was a significant difference in that the BDNF plasma levels in the control group were lower than in the treatment group, with a p<0.001 (CI = 95%). The median ST serum level in the treatment group was 25.78 with an IQR of 9.61 ng/mL, while the median ST serum level in the control group was 7.5 with an IQR of 0.38 ng/mL. Statistically, the difference is significant from the p value <0.001. The median SPT score in the treatment group was 84.5 with an interquartile range (IQR) of 12%, while the median SPT value in the control group was 67 with an IQR of 8%.
Conclusion: There was an effect of probiotics as an adjuvant antidepressant therapy in male Wistar rats with anhedonic behavior.
The correlation of neutrophil-lymphocyte ratio and ENLIST ENL severity scale in type 2 leprosy reactions
Authors: Rosyada Rahma , Lubis Ramona Dumasari , Siregar Remenda 
Published: May 2024

Link of Video Abstract: https://youtu.be/PlVYFXCyDlY

Introduction: Type 2 leprosy reaction or Erythema Nodosum Leprosum (ENL) is an episode of acute inflammation that appears in the clinical course of leprosy. In ENL, antigen-antibody immune complex responses and the complement immune system are suspected. The Neutrophil-Lymphocyte Ratio (NLR) is an easy, inexpensive, and usable parameter related to clinical outcome and disease severity. The ENLIST ENL Severity Scale (EESS) is the world's first validated ENL severity scale. This study aimed to determine correlations between the NLR and the EESS in type 2 leprosy reactions.
Methods: Observational analytic study with a cross-sectional approach was used in this study. The sample of the study was 30 subjects with type 2 leprosy reactions. The recording of basic data and examination of the study subjects included assessing the degree of severity using the ENLIST ENL severity scale and measuring the neutrophil-lymphocyte ratio. Statistical analysis was performed using Pearson's correlation coefficient, with p≤0.05 considered statistically significant.
Results: The research subjects with the highest distribution were in the age group <40 years (73.33%) and male (66.67%). The mean EESS score was 7.97 ± 1.73, with the category of the highest degree of severity in all subjects being mild (60.0%). The mean NLR value for all issues was 7.60 ± 3.58. There was a significantly strong positive correlation between NLR and EESS in type 2 leprosy reactions (p<0.001, r=0.653).
Conclusions: There was a strong correlation between NLR and EESS in type 2 leprosy reactions.
Plasma collection in Indonesia - a challenge to implement fractionation
Authors: Triyono Teguh Triyono , Bidayah Hasna Fadlilatul 
Published: May 2024

In recent years, the national usage of Plasma Derived Medicinal Products (PDMPs), particularly albumin and immunoglobulin, has expanded due to a rise in disease prevalence, as well as enhanced patient management practices and broader assurance coverage. Now, Indonesia is a country that imports all of its PDMPs, resulting in high pricing and market reliance; nevertheless, barely a third of recovered plasma gets transfused to patients. The plasma that has not been used should be discarded, at a cost. The government intended to begin meeting the needs of the PDMP by implementing the plasma fractionation program. The decision was taken to use contract fractionation for three years, after which a national fractionation manufacturer was anticipated. The potential utility of recovered plasma and the prospective requirement for plasmapheresis collection have been assessed. The Minister of Health has enacted legislation concerning plasma fractionation, including the potential of establishing plasmapheresis centers to facilitate plasma collections. The Food and Drug Administration of Indonesia has also initiated a certification scheme for blood establishments (BEs), and only certified BEs can provide plasma for fractionation. After the epidemic, the government restarted the fractionation program by modifying existing laws to allow private manufacturers to participate. The difficulty was obtaining plasma from uncompensated donors, recruiting plasma donors, increasing the number of qualified biological examiners, of which only 19 out of 469 have been certified, and increasing technology and personnel capacities. Other significant obstacles were the harmonization or consolidation of existing biological entities (BEs) and the expense of paying for recovered and source plasma. The government and other parties involved had to make substantial efforts and collaborate to overcome these problems.
Comparison of freeze dried human amniotic membrane and its combination with platelet rich fibrin for the epithelial acceleration in an acute wound excision using Rattus Novergicus study model
Authors: Pratama Yanuar Ari , Zarasade Lobredia , Nata’atmadja Beta Subakti , Nurdianto Arif Rahman 
Published: May 2024

Link of Video Abstract: https://youtu.be/FvU45HL3HyE

Introduction: Human amniotic membrane and platelet rich fibrin (PRF) are biological materials that can accelerate wound healing through their content of growth factors and cytokines. This study aimed to determine the effectiveness of the combination of these two biological agents for wound healing.
Methods: This study used an experimental method with a randomized post-test only control group design, to compare the use of human amniotic membrane alone with a combination of human amniotic membrane and PRF in acute full thickness wounds of the skin of Wistar rats. The research subjects were 32 rats which were divided into four groups. Groups 1 and 2 used human amniotic membrane, while groups 3 and 4 used a combination of human amniotic membrane and PRF, then the epithelialization process was observed on the 3rd and 6th day.
Result: There was no statistically significant difference in the speed of epithelialization of excision wounds on the backs of rats on the third day (Significance 0.498) and Sixth (Significance 0.9) between the Amnion group and the combination of amnion and PRF because it was greater than α = 0.05.
Conclusion: The use of a combination of freeze dried human amniotic membrane and platelet rich fibrin was not significantly more effective than freeze dried human amniotic membrane in accelerating the epithelialization of acute full thickness excision wounds in rats (Rattus novergicus).
Mindfulness eating based on spiritual interventions on diet compliance and blood sugar levels in type 2 DM patients
Authors: Riska Rohmawati  , Lono Wijayanti  , Ratna Yunita Sari  , Imamatul Faizah  , Rahayu Anggraini  
Published: May 2024

Introduction: Diet is one component of diabetes mellitus (DM) self-management for controlling blood sugar levels. Several obstacles in the implementation of the diet program have the potential for non-compliance, so that blood sugar levels tend to increase. Mindfulness eating based on spiritual intervention is one of the interventions that is expected to form adaptive eating behavior control to achieve dietary compliance and controlled blood sugar levels. The purpose of this study was to analyze the effect of mindfulness eating based on spiritual intervention on dietary compliance and blood sugar levels in patients with type 2 diabetes.
Methods: The study's quasi-experimental, untreated control group design included dependent pre- and post-test samples. The population used was all patients with type 2 diabetes. The sample was taken using a simple random sampling technique with determination according to inclusion and exclusion criteria. The independent variables in this study were mindfulness eating based on spiritual intervention, while the dependent variables were dietary compliance and blood sugar levels. A glucometer and the Personal Diabetes Questionnaire (PDQ) were the tools employed in this investigation. The t-test was used as the statistical test.
Results: There were a total of 50 samples that were divided between the control group and the intervention group. The results of the statistical test showed that mindfulness eating based on spiritual intervention had a statistically significant effect on dietary compliance (p < 0.001) and blood glucose levels (p < 0.001) compared to the control group.
Conclusion: The value of diet adherence is greatly increased by mindfulness eating practices based on spiritual intervention, and mean blood glucose levels are significantly reduced at the conclusion of the study. Exercises in mindfulness eating that are based on spiritual intervention can be popularized as a way to deal with dietary issues and blood sugar regulation.
Effect of dexmedetomidine administration on malondialdehyde levels in lower extremity surgery using tourniquets
Authors: Wijanarko Bayu , Airlangga Prananda Surya , Fitriati Mariza , Sumartono Christrijogo , Kriswidyatomo Prihatma , Lestari Pudji 
Published: May 2024

Introduction: The use of a tourniquet in lower extremity surgery can help surgeons optimize the surgical field. However, tourniquet inflation may create ischemic conditions in the extremity, and tourniquet deflation may pose a risk of ischemic reperfusion injury (IRI). Ischemic conditions can increase the production of reactive oxidative stress (ROS), which, if it occurs simultaneously with IRI, will produce malondialdehyde (MDA), a toxic metabolite. The prolonged use of tourniquets can cause damage to the local skin tissue at the tourniquet inflation and poses a risk of IRI to other organs. This study aims to observe the effect of dexmedetomidine administration on malondialdehyde levels in lower extremity surgery using tourniquets.
Methods: This study is an observational study with a prospective cohort design to measure malondialdehyde levels in lower extremity surgery using tourniquets. When the data were normally distributed, a statistical test was performed using an independent sample t-test to compare the demographic data of the two groups. To compare the results of the observation after the induction, 15 and 120 minutes after the release of the tourniquets, a repeated measures ANOVA was performed when the data were normally distributed. Then, to examine the correlation between variables, Spearman's correlation test was applied when the data were not normally distributed.
Results: In this study, almost all the subjects in the isoflurane and dex-iso groups had no significantly different characteristics, and also showed no effect of tourniquet pressure on malondialdehyde levels.
Conclusion: Based on statistical analysis and discussion of the effect of dexmedetomidine administration on malondialdehyde levels in lower extremity surgery using tourniquets, it can be concluded that there was no statistically significant effect of dexmedetomidine administration on malondialdehyde levels in lower extremity surgery using tourniquets.