bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of deep Czech Republic–Austria transboundary aquifer discharge and associated river chloride loading
Authors: Chroustová Kateřina , Říčka Adam , Pasternáková Bibiána , Kuchovský Tomáš , Rüde Thomas R. , Zeman Josef 
Published: May 2024

AbstractThe deep transboundary aquifer of regional scale along the Czech Republic–Austria border in Central Europe serves as a thermal-mineral water resource for balneotherapy and plays an important role in the region’s development. The aquifer is composed mostly of Jurassic carbonates at depths from 160 to − 3000 masl. Despite more than two decades of exploitation, no complex analysis of groundwater flow directions and groundwater fluxes ever took place. Now, cross-border cooperation enabled the research team to gather crucial information on the Jurassic aquifer. For a better understanding of the groundwater flow system, a numerical model was developed. To simulate the effect of variable density and viscosity occurring in such a deep aquifer, the SEAWAT numerical model was used. The simulation shows that there is an inflow of low mineralised groundwater from the crystalline outcrops in the northwest and inflow of saline groundwater from southeast. Aquifer discharge was identified along the zone partly corresponding to the course of the Dyje River. To check the model’s accuracy, the river water was sampled together with streamflow measurements. Detected sections of increasing chloride concentration indicate zones of the Jurassic aquifer discharge into the Dyje River. The discharge rate of 85 L/s derived from streamflow and chloride concentrations matches the value computed by the model. The relatively high discharge of the Jurassic aquifer contributes significantly to the high chloride loading observed in the Dyje River.
Breast Cancer Education and Empowerment in Ethiopia: Evaluating Community-Based Cancer Prevention Efforts Using the RE-AIM Framework
Authors: Lott Breanne E. , Yeo Sarah , Bekele Etsegenet , Birhanu Firaol , Hussein Rehima , Muktar Seada , Mengiste Tsion , Asfaw Emebet , Madhivanan Purnima , Deressa Biniyam Tefera 
Published: May 2024

AbstractCancer prevention challenges in Ethiopia include limited community awareness and low uptake of screening, which are in part driven by a lack of culturally and linguistically relevant cancer education appropriate for the diverse indigenous communities of this never-colonized nation. In 2022, a comprehensive multi-media breast cancer (BC) awareness campaign was implemented, featuring local cancer experts and survivors, with community-based screening events in the towns of Adama and Mojo. The RE-AIM framework was used to evaluate and describe its reach, effectiveness, adoption, implementation, and maintenance. Educational pamphlets, videos, social media posts, and interviews were distributed in person and through local and national media networks, reaching tens of millions of people and resulting in 525 individuals screened, with one diagnosis of early-stage cancer. During the free screening events, an interview-administered survey of BC knowledge, attitudes, and screening practices was conducted to inform future cancer education for this population. Among 287 survey respondents, about half correctly identified swelling (46%) or changing nipples/discharge (48.4%) as signs of BC. Maintenance challenges include the lack of a national screening program. Educational resources and a mobile app, translated into the local language, encourage continued patient empowerment to perform breast self-exams. In the absence of established BC prevention programs, “pop-up” mobile screening events can be effective for mobilizing communities to get screened. The paper highlights challenges and lessons gleaned from this community-based BC awareness campaign and screening event to inform future cancer education initiatives in Ethiopia and similar resource-limited settings.
An exploration of the motivations of catfish perpetrators and the emotions and feelings expressed by catfish victims using automated linguistic analysis and thematic analysis
Authors: Ryan Samuel , Taylor Jacqui 
Published: May 2024

AbstractCatfishing is a form of online deception where an individual presents themselves as an identity that is not their own. The study reported in this article explored the motivations for catfish perpetrators and the impacts on those who had been catfished in terms of the emotions and feelings expressed by victims. Data was collected using the crowd-sourced question and answer website Quora [1] and analysis was conducted on a pre-existing corpus of data which contained participant’s answers to questions on catfishing. An automated linguistic analysis using Linguistic Inquiry and Word Count (LIWC-2022 [2]) and a thematic analysis (Braun and Clarke in Qual Res Psychol 3:77–101, 2006 [38]) were conducted on participant’s descriptions of their perceptions of the motivations of catfishes and their catfishing experiences. The thematic analysis indicated that the motivations of catfish perpetrators can be linked to entertainment, emulating an ideal self, desiring meaningful interaction, and financial gain. Six emotions and feelings emerged from the accounts of catfishing victims: suspicion, love, depression, anger, embarrassment, and stupidity. These findings contribute to an understanding of what motivates individuals to catfish and suggests further research to explore specific emotions and feelings that catfish victims experience. The LIWC analysis and language style matching analysis showed that the data collected was mostly personal to each individual and that there were similarities in how victims write about their experiences. Therefore, we suggest that LIWC has promise as a method of providing added context to qualitative data analysis methods.
Kant on Self-Control
Authors: Vujošević Marijana 
Published: May 2024

This Element considers Kant's conception of self-control and the role it plays in his moral philosophy. It offers a detailed interpretation of the different terms used by Kant to explain the phenomenon of moral self-control, such as 'autocracy' and 'inner freedom'. Following Kant's own suggestions, the proposed reading examines the Kantian capacity for self-control as an ability to 'abstract from' various sensible impressions by looking beyond their influence on the mind. This analysis shows that Kant's conception of moral self-control involves two intimately related levels, which need not meet the same criteria. One level is associated with realizing various ends, the other with setting moral ends. The proposed view most effectively accommodates self-control's role in the adoption of virtuous maxims and ethical end-setting. It explains why self-control is central to Kant's conception of virtue and sheds new light on his discussions of moral strength and moral weakness.
Introducing The View from the Sea. The Practice of Early Modern Transoceanic Commercial Navigation
Authors: Iannuzzi Giulia 
Published: May 2024

AbstractResearch into maritime history using digital tools is a growing field, with projects that in recent years have focused on the role of sea spaces in the dynamics of globalisation on an economic and juridical level as well as on a cultural level, with respect to the circulation of knowledge. In this introduction to our special issue, we offer some historiographical observations on the codification of knowledge in seafaring practice, emphasising how the use of digital tools to process and represent primary sources may encourage historians to formulate new questions about the relationship between European culture and the sea during the early modern age. In order to present the articles in this issue and the original contribution they make to the field, we also focus on the historical and cultural significance and methodological challenges posed by primary sources such as logbooks. We illustrate how the analysis of logbooks in a digital environment such as Global Sea Routes (GSR), a project conceived and coordinated by Guido Abbattista, can foster a better understanding of the role of routine navigations in early commercial globalisation.
Trade-offs in fishing strategy decisions and conservation implications for small-scale fisheries
Authors: Wade Eric , Biedenweg Kelly 
Published: May 2024

SummaryPeople are psychologically predisposed to minimize their losses, even in the face of substantial gains. This predisposition, referred to as ‘loss aversion’, is especially present when people face uncertain outcomes. In small-scale fisheries, where fishers’ decisions are influenced by monetary and non-monetary assets, exploring how loss aversion intersects with conservation efforts may offer insights into how fishers balance short-term and long-term priorities. This study assessed the variables that contribute to loss aversion of small-scale fishers when making trade-offs between two valued assets: information-sharing and catch success. We used a structured questionnaire and a hypothetical simple lottery choice task of 78 fishers across 20 fishing beaches in Jamaica. We found that fishers were marginally more loss averse when both information-sharing opportunities and catch success were threatened than when only catch success was threatened. Communication frequency and size of fishing crew contributed significantly to fishers’ loss aversion in most choice sets, regardless of whether materially or non-materially valued assets were threatened. By exploring the drivers underpinning fishers’ choices, we provide insights into how the consideration of these variables can support the development of fisheries conservation measures that better align with the decision priorities of fishers.
A Regionally Refined and Mass‐Consistent Atmospheric and Hydrological De‐Aliasing Product for GRACE, GRACE‐FO and Future Gravity Missions
Authors: Springer Anne , Mielke Christian A. , Liu Ziyu , Dixit Shashi , Friederichs Petra , Kusche Jürgen 
Published: May 2024

AbstractDe‐aliasing products are used in the estimation process of satellite‐based gravity field computation to reduce errors from high‐frequency mass variations that alias into monthly gravity fields. The latest official product is AOD1B RL07 and describes non‐tidal atmosphere and oceanic mass variations at 3‐hourly resolution. However, the model‐based de‐aliasing products are inevitably incomplete and prone to temporally and spatially correlated errors that substantially contribute to errors in the estimated gravity fields. Here, we investigate possible enhancement of current de‐aliasing products by nesting a regional high‐resolution atmospheric reanalysis over Europe into a global reanalysis. As further novelty we include almost mass consistent terrestrial water storage variability from a regional hydrological model nested into a global model as additional component of the de‐aliasing product. While we find in agreement with earlier studies only minor contributions from increasing the temporal resolution beyond 3‐hourly data, our investigations suggest that contributions from continental hydrology and from regional non‐hydrostatic atmospheric modeling to sub‐monthly mass variations could be relevant already for gravity fields estimated from current gravity missions. Moreover, in the context of extreme events, we find regionally contributions from additional moisture fields, such as cloud liquid water, in the order of a few mm over Europe. We suggest this needs to be taken into account when preparing data analysis schemes for future space gravimetric missions.
AGU Publications Updates Authorship Policy to Foster Greater Equity and Transparency in Global Research Collaborations
Authors: Xenopoulos Marguerite A. , Bond‐Lamberty Ben , Desai Ankur R. , Huntzinger Deborah , Buchanan Paula R. , East Amy E. , Singh Arvind , Wooden Paige , Jewett Kevin , Ricci Mia 
Published: May 2024

AbstractAGU Publications encourages research collaborations between regions, countries, and communities. When well‐resourced researchers complete research or field work in low‐resourced settings while excluding local communities or researchers from the process, this can be referred to as parachute science or helicopter research. To help address concerns of parachute science and to promote greater equity and transparency in global research collaborations, AGU Publications has updated its authorship policy across its scholarly journals. The implementation of this policy follows a successful 18‐month pilot at JGR: Biogeosciences. For research completed in low‐resourced regions, authors are encouraged to include a disclosure statement pertaining to the ethical and scientific considerations of their research collaborations.
Peaks, sources, and immediate health impacts of PM2.5 and PM1 exposure in Indonesia and Taiwan with microsensors
Authors: Lung Shih-Chun Candice , Tsou Ming-Chien Mark , Cheng Chih-Hui Chloe , Setyawati Wiwiek 
Published: May 2024

Abstract
Background
Microsensors have been used for the high-resolution particulate matter (PM) monitoring.

Objectives
This study applies PM and health microsensors with the objective of assessing the peak exposure, sources, and immediate health impacts of PM2.5 and PM1 in two Asian countries.

Methods
Exposure assessment and health evaluation were carried out for 50 subjects in 2018 and 2019 in Bandung, Indonesia and for 55 subjects in 2019 and 2020 in Kaohsiung, Taiwan. Calibrated AS-LUNG sets and medical-certified RootiRx® sensors were used to assess PM and heart-rate variability (HRV), respectively.

Results
Overall, the 5-min mean exposure of PM2.5 and PM1 was 30.4 ± 20.0 and 27.0 ± 15.7 µg/m3 in Indonesia and 14.9 ± 11.2 and 13.9 ± 9.8 µg/m3 in Taiwan, respectively. The maximum 5-min peak PM2.5 and PM1 exposures were 473.6 and 154.0 µg/m3 in Indonesia and 467.4 and 217.7 µg/m3 in Taiwan, respectively. Community factories and mosquito coil burning are the two most important exposure sources, resulting in, on average, 4.73 and 5.82 µg/m3 higher PM2.5 exposure increments for Indonesian subjects and 10.1 and 9.82 µg/m3 higher PM2.5 exposure for Taiwanese subjects compared to non-exposure periods, respectively. Moreover, agricultural waste burning and incense burning were another two important exposure sources, but only in Taiwan. Furthermore, 5-min PM2.5 and PM1 exposure had statistically significantly immediate impacts on the HRV indices and heart rates of all subjects in Taiwan and the scooter subjects in Indonesia with generalized additive mixed models. The HRV change for a 10 µg/m3 increase in PM2.5 and PM1 ranged from −0.9% to −2.5% except for ratio of low-high frequency, with greater impacts associated with PM1 than PM2.5 in both countries.

Impact statement
This work highlights the ability of microsensors to capture high peaks of PM2.5 and PM1, to identify exposure sources through the integration of activity records, and to assess immediate changes in heart rate variability for a panel of approximately 50 subjects in Indonesia and Taiwan. This study stands out as one of the few to demonstrate the immediate health impacts of peak PM, complementing to the short-term (days or weeks) or long-term effects (months or longer) assessed in most epidemiological studies. The technology/methodology employed offer great potential for researchers in the resource-limited countries with high PM2.5 and PM1 levels.
Altered cortical synaptic lipid signaling leads to intermediate phenotypes of mental disorders
Authors: Tüscher Oliver , Muthuraman Muthuraman , Horstmann Johann-Philipp , Horta Guilherme , Radyushkin Konstantin , Baumgart Jan , Sigurdsson Torfi , Endle Heiko , Ji Haichao , Kuhnhäuser Prisca , Götz Jan , Kepser Lara-Jane , Lotze Martin , Grabe Hans J. , Völzke Henry , Leehr Elisabeth J. , Meinert Susanne , Opel Nils , Richers Sebastian , Stroh Albrecht , Daun Silvia , Tittgemeyer Marc , Uphaus Timo , Steffen Falk , Zipp Frauke , Groß Joachim , Groppa Sergiu , Dannlowski Udo , Nitsch Robert , Vogt Johannes 
Published: May 2024

AbstractExcitation/inhibition (E/I) balance plays important roles in mental disorders. Bioactive phospholipids like lysophosphatidic acid (LPA) are synthesized by the enzyme autotaxin (ATX) at cortical synapses and modulate glutamatergic transmission, and eventually alter E/I balance of cortical networks. Here, we analyzed functional consequences of altered E/I balance in 25 human subjects induced by genetic disruption of the synaptic lipid signaling modifier PRG-1, which were compared to 25 age and sex matched control subjects. Furthermore, we tested therapeutic options targeting ATX in a related mouse line. Using EEG combined with TMS in an instructed fear paradigm, neuropsychological analysis and an fMRI based episodic memory task, we found intermediate phenotypes of mental disorders in human carriers of a loss-of-function single nucleotide polymorphism of PRG-1 (PRG-1R345T/WT). Prg-1R346T/WT animals phenocopied human carriers showing increased anxiety, a depressive phenotype and lower stress resilience. Network analysis revealed that coherence and phase-amplitude coupling were altered by PRG-1 deficiency in memory related circuits in humans and mice alike. Brain oscillation phenotypes were restored by inhibtion of ATX in Prg-1 deficient mice indicating an interventional potential for mental disorders.
Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks
Authors: Ertl Natalie , Freeman Tom P. , Mokrysz Claire , Ofori Shelan , Borissova Anna , Petrilli Kat , Curran H. Valerie , Lawn Will , Wall Matthew B. 
Published: May 2024

AbstractAdolescence is a time of rapid neurodevelopment and the endocannabinoid system is particularly prone to change during this time. Cannabis is a commonly used drug with a particularly high prevalence of use among adolescents. The two predominant phytocannabinoids are Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), which affect the endocannabinoid system. It is unknown whether this period of rapid development makes adolescents more or less vulnerable to the effects of cannabis on brain-network connectivity, and whether CBD may attenuate the effects of THC. Using fMRI, we explored the impact of vaporized cannabis (placebo, THC: 8 mg/75 kg, THC + CBD: 8 mg/75 kg THC & 24 mg/75 kg CBD) on resting-state networks in groups of semi-regular cannabis users (usage frequency between 0.5 and 3 days/week), consisting of 22 adolescents (16–17 years) and 24 young adults (26–29 years) matched for cannabis use frequency. Cannabis caused reductions in within-network connectivity in the default mode (F[2,88] = 3.97, P = 0.022, η² = 0.018), executive control (F[2,88] = 18.62, P < 0.001, η² = 0.123), salience (F[2,88] = 12.12, P < 0.001, η² = 0.076), hippocampal (F[2,88] = 14.65, P < 0.001, η² = 0.087), and limbic striatal (F[2,88] = 16.19, P < 0.001, η² = 0.102) networks compared to placebo. Whole-brain analysis showed cannabis significantly disrupted functional connectivity with cortical regions and the executive control, salience, hippocampal, and limbic striatal networks compared to placebo. CBD did not counteract THC’s effects and further reduced connectivity both within networks and the whole brain. While age-related differences were observed, there were no interactions between age group and cannabis treatment in any brain network. Overall, these results challenge the assumption that CBD can make cannabis safer, as CBD did not attenuate THC effects (and in some cases potentiated them); furthermore, they show that cannabis causes similar disruption to resting-state connectivity in the adolescent and adult brain.
Unmet healthcare needs, access to services and experiences with health providers among persons with spinal cord injury in Australia
Authors: Borg Samantha J. , Borg David N. , Arora Mohit , Middleton James W. , Marshall Ruth , Nunn Andrew , Geraghty Timothy 
Published: May 2024

Abstract
Study design
Cross-sectional survey.

Objectives
Appropriate and timely lifelong access to healthcare following a spinal cord injury (SCI) is critical, yet unmet healthcare needs in this population are common. Poor experiences with healthcare providers can be a barrier to health-seeking behaviour, and we hypothesised that there would be an association between unmet healthcare needs and care experiences. This study aimed to: (1) describe healthcare provider utilisation in the past year, unmet care needs and satisfaction with healthcare services; (2) explore the association between experiences with healthcare providers and unmet healthcare needs; and (3) explore the association between healthcare provider utilisation and participant characteristics, including unmet healthcare needs.

Setting
Community.

Methods
Analysis of data for 1579 Australians aged ≥ 18, who were ≥ 1-year post-SCI and living in the community. Bayesian penalised regression was used to model six binary outcomes: unmet healthcare needs; the use of general practitioners (GPs), allied health practitioners, rehabilitation specialists; medical specialists; and hospitalisations in the past 12-months.

Results
Unmet needs were reported by 17% of participants, with service cost the common deterrent. There was evidence of an effect for provider experiences on unmet healthcare needs, but no evidence that unmet healthcare needs was associated with the use of GPs, allied health practitioners, and rehabilitation or medical specialists.

Conclusions
Unmet healthcare needs were reported in the context of high healthcare use and large proportions of secondary conditions in a cohort with long-term SCI. Improved health access for people with SCI include better primary-secondary care collaboration is needed.
Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors
Authors: Gonçalves Joana , Amaral Joana D. , Capela Rita , Perry Maria de Jesus , Braga Cláudia , Gaspar Maria Manuela , Piedade Fátima M. , Bijlsma Lubertus , Roig Antoni , Pinto Sandra N. , Moreira Rui , Florindo Pedro , Rodrigues Cecília M. P. 
Published: May 2024

AbstractInducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compounds have received relatively little attention as triggers of necroptosis. The development of ruthenium (II) hybrid compounds, particularly those containing triazene (Ru-TRZ), highlights a novel avenue for modulating necroptotic cell death. Here we show that incorporating a methyltriazene moiety, a known alkylating warhead, confers superior mitochondrial-targeting properties and enhances cell death compared to amide-containing counterparts. Ru-hybrid TRZ2 exhibits also antitumor efficacy against in vivo drug-resistant cancer cells. Mechanistically, we demonstrate that Ru-TRZ hybrids induce apoptosis. In addition, by activating downstream RIPK3-driven cell death, TRZ2 proficiently restrains normal mitochondrial function and activity, leading to cancer cell necroptosis. Finally, TRZ2 synergizes anti-proliferative activity and cell death effects induced by conventional drugs. In conclusion, Ru-TRZ2 stands as a promising ruthenium-based chemotherapeutic agent inducing necroptosis in drug resistant cancer cells.