bluuebunny/crossref_metadata_2025_split huggingface dataset:
Typicality- and instance-dependent label noise-combating: a novel framework for simulating and combating real-world noisy labels for endoscopic polyp classification
Authors: Gao Yun , Fu Junhu , Wang Yuanyuan , Guo Yi 
Published: May 2024

AbstractLearning with noisy labels aims to train neural networks with noisy labels. Current models handle instance-independent label noise (IIN) well; however, they fall short with real-world noise. In medical image classification, atypical samples frequently receive incorrect labels, rendering instance-dependent label noise (IDN) an accurate representation of real-world scenarios. However, the current IDN approaches fail to consider the typicality of samples, which hampers their ability to address real-world label noise effectively. To alleviate the issues, we introduce typicality- and instance-dependent label noise (TIDN) to simulate real-world noise and establish a TIDN-combating framework to combat label noise. Specifically, we use the sample’s distance to decision boundaries in the feature space to represent typicality. The TIDN is then generated according to typicality. We establish a TIDN-attention module to combat label noise and learn the transition matrix from latent ground truth to the observed noisy labels. A recursive algorithm that enables the network to make correct predictions with corrections from the learned transition matrix is proposed. Our experiments demonstrate that the TIDN simulates real-world noise more closely than the existing IIN and IDN. Furthermore, the TIDN-combating framework demonstrates superior classification performance when training with simulated TIDN and actual real-world noise.
Determination of global geodetic parameters using satellite laser ranging to Galileo, GLONASS, and BeiDou satellites
Authors: Li Xingxing , Lou Jiaqing , Yuan Yongqiang , Wu Jiaqi , Zhang Keke 
Published: May 2024

AbstractThe new Global Navigation Satellite System (GNSS) satellites, including GLONASS, Galileo, and BeiDou system, are equipped with Laser Retroreflector Arrays (LRA) to support Satellite Laser Ranging (SLR) tracking, which contributes to the estimation of global geodetic parameters. In this study, we estimate the global geodetic parameters using the SLR observations to GNSS satellites and also investigate the effects of different data processing strategies on the estimated Earth Rotation Parameters (ERP), geocenter motion, and terrestrial scale. The results indicate that setting range bias parameters for each satellite-station pair can effectively account for the satellite-specific biases induced by LRAs, leading to smaller Root Mean Square Errors (RMSE) of the post-fit SLR residuals. Furthermore, estimating the range biases for each satellite-station pair improves the accuracy of the estimated station coordinates and ERP. We also examine the impact of different arc lengths on the estimates of ERP, geocenter motion, and terrestrial scale. The results show that extending arc length can significantly reduce the formal error of ERP. The 7-day strategy produces the smallest RMSEs of 473 microarcseconds and 495 microarcseconds for the estimated X- and Y-component of pole coordinates, and 52 microseconds for length-of-day, respectively. However, the estimated geocenter motion is less affected by the arc length, even the shortest 1-day arc strategy can capture the seasonal variations of geocenter motion in Z component. For scale estimation, extending the arc length notably improves the accuracy of the estimated station coordinates and scale, but this advantage becomes less noticeable in longer arcs. The 7-day solution also obtains the closet scale results compared to ITRF2014, with the RMSE of 2.10 × 10–9.
Unusual location of pleomorphic xanthoastrocytoma: a case report
Authors: Alharbi Sara T. , Alrehaili Mona , Alhujaily Ahmed , Almashni Aysam Adnan , Almughathawi Abdulrahman 
Published: May 2024

Abstract
Background
Pleomorphic xanthoastrocytoma is a rare astrocytic tumor often diagnosed at a young age. Typically, they appear as supratentorial cortical tumors, frequently involving the temporal lobe with few reported rare locations. The prognosis is favorable following surgical excision; however, recurrence, dissemination, and anaplastic transformation occurred in some cases.

Case presentation
A 50-year-old female presented with convulsions and an altered consciousness. Imaging showed a periventricular mixed solid and cystic lesion. Histopathological examination revealed features of pleomorphic xanthoastrocytoma WHO grade 2 without necrosis or mitotic activity.

Conclusions
This report highlights the classic imaging findings of pleomorphic xanthoastrocytoma but in an atypical periventricular location. Although rare, pleomorphic xanthoastrocytoma should be considered in the differential diagnosis of mixed solid and cystic periventricular lesions.
Cascaded chiral birefringent media enabled planar lens with programable chromatic aberration
Authors: Zhang Dewei , Xu Chun-Ting , Chen Quan-Ming , Cao Han , Yu Hong-Guan , Tan Qing-Gui , Lu Yan-qing , Hu Wei 
Published: May 2024

AbstractWavefront control is the fundamental requirement in optical informatics. Planar optics have drawn intensive attention due to the merits of compactness and light weight. However, it remains a challenge to freely manipulate the dispersion, hindering practical applications, especially in imaging. Here, we propose the concept of frequency-synthesized phase engineering to solve this problem. A phasefront-frequency matrix is properly designed to encode different spatial phases to separate frequencies, thus makes arbitrary dispersion tailoring and even frequency-separated functionalization possible. The periodically rotated director endows cholesteric liquid crystal with a spin and frequency selective reflection. Moreover, via presetting the local initial orientation of liquid crystal, geometric phase is encoded to the reflected light. We verify the proposed strategy by cascading the chiral anisotropic optical media of specifically designed helical pitches and initial director orientations. By this means, planar lenses with RGB achromatic, enhanced chromatic aberration and color routing properties are demonstrated. Inch-sized and high-efficient lenses are fabricated with low crosstalk among colors. It releases the freedom of dispersion control of planar optics, and even enables frequency decoupled phase modulations. This work brings new insights to functional planar optics and may upgrade the performance of existing optical apparatuses.
Prevalence and correlates of manic/hypomanic and depressive predominant polarity in bipolar disorder: systematic review and meta-analysis
Authors: Bartoli Francesco , Bassetti Carlo , Gazzola Marco , Gianfelice Letizia , Cavaleri Daniele , Crocamo Cristina , Carrà Giuseppe 
Published: May 2024

BackgroundIdentification of the predominant polarity, i.e. hypomanic/manic (mPP) or depressive predominant polarity (dPP), might help clinicians to improve personalised management of bipolar disorder.AimsWe performed a systematic review and meta-analysis to estimate prevalence and correlates of mPP and dPP in bipolar disorder.MethodThe protocol was registered in the Open Science Framework Registries (https://doi.org/10.17605/OSF.IO/8S2HU). We searched main electronic databases up to December 2023 and performed random-effects meta-analyses of weighted prevalence of mPP and dPP. Odds ratios and weighted mean differences (WMDs) were used for relevant correlates.ResultsWe included 28 studies, providing information on rates and/or correlates of mPP and dPP. We estimated similar rates of mPP (weighted prevalence = 30.0%, 95% CI: 23.1 to 37.4%) and dPP (weighted prevalence = 28.5%, 95% CI: 23.7 to 33.7%) in bipolar disorder. Younger age (WMD = −3.19, 95% CI: −5.30 to −1.08 years), male gender (odds ratio = 1.39, 95% CI: 1.10 to 1.76), bipolar-I disorder (odds ratio = 4.82, 95% CI: 2.27 to 10.24), psychotic features (odds ratio = 1.56, 95% CI: 1.01 to 2.41), earlier onset (WMD = −1.57, 95% CI: −2.88 to −0.26 years) and manic onset (odds ratio = 13.54, 95% CI: 5.83 to 31.46) were associated with mPP (P < 0.05). Depressive onset (odds ratio = 12.09, 95% CI: 6.38 to 22.90), number of mood episodes (WMD = 0.99, 95% CI: 0.28 to 1.70 episodes), history of suicide attempts (odds ratio = 2.09, 95% CI: 1.49 to 2.93) and being in a relationship (odds ratio = 1.98, 95% CI: 1.22 to 3.22) were associated with dPP (P < 0.05). No differences were estimated for other variables.ConclusionsDespite some limitations, our findings support the hypothesis that predominant polarity might be a useful specifier of bipolar disorder. Evidence quality was mixed, considering effects magnitude, consistency, precision and publication bias. Different predominant polarities may identify subgroups of patients with specific clinical characteristics.
Interaction between mental disorders and social disconnectedness on mortality: a population-based cohort study
Authors: Laustsen Lisbeth Mølgaard , Ejlskov Linda , Chen Danni , Lasgaard Mathias , Gradus Jaimie L. , Østergaard Søren Dinesen , Grønkjær Marie Stjerne , Plana-Ripoll Oleguer 
Published: May 2024

BackgroundDespite the recognised importance of mental disorders and social disconnectedness for mortality, few studies have examined their co-occurrence.AimsTo examine the interaction between mental disorders and three distinct aspects of social disconnectedness on mortality, while taking into account sex, age and characteristics of the mental disorder.MethodThis cohort study included participants from the Danish National Health Survey in 2013 and 2017 who were followed until 2021. Survey data on social disconnectedness (loneliness, social isolation and low social support) were linked with register data on hospital-diagnosed mental disorders and mortality. Poisson regression was applied to estimate independent and joint associations with mortality, interaction contrasts and attributable proportions.ResultsA total of 162 497 individuals were followed for 886 614 person-years, and 9047 individuals (5.6%) died during follow-up. Among men, interaction between mental disorders and loneliness, social isolation and low social support, respectively, accounted for 47% (95% CI: 21–74%), 24% (95% CI: −15 to 63%) and 61% (95% CI: 35–86%) of the excess mortality after adjustment for demographics, country of birth, somatic morbidity, educational level, income and wealth. In contrast, among women, no excess mortality could be attributed to interaction. No clear trends were identified according to age or characteristics of the mental disorder.ConclusionsMortality among men, but not women, with a co-occurring mental disorder and social disconnectedness was substantially elevated compared with what was expected. Awareness of elevated mortality rates among socially disconnected men with mental disorders could be of importance to qualify and guide prevention efforts in psychiatric services.
Pancreatic Neuroendocrine Tumors in French VHL Mutation Carriers
Authors: Muller Marie , Hammel Pascal , Couvelard Anne , Védie Anne-Laure , Cros Jérôme , Burnichon Nelly , Hercent Agathe , Sauvanet Alain , Richard Stéphane , de Mestier Louis 
Published: May 2024

Abstract

Context
Von Hippel-Lindau disease (VHL) is a rare, autosomal-dominant hereditary cancer-predisposition syndrome caused by germline pathogenic variants (PVs) in the VHL gene. It is associated with a high penetrance of benign and malignant vascular tumors in multiple organs, including pancreatic neuroendocrine tumors (PanNETs), whose long-term natural history is ill-known.

Objective
The aim of this study was to identify prognostic factors associated with VHL-related PanNETs, notably the role of genotype-phenotype correlations.

Methods
Patients with both documented germline PV in the VHL gene and PanNETs included in the French PREDIR database between 1995 and 2022 were included. The primary end point was the proportion of patients with PanNET-related metastases, and the secondary end point was overall survival (OS). Genotype/phenotype correlations were studied.

Results
We included 121 patients with 259 PanNETs. Median age at diagnosis was 38 years. Median follow-up was 89.5 months. PanNET surgical resection was performed in 51 patients. Overall, 29 patients (24%) had metastases (5 synchronous, 10 metachronous), with a higher risk in case of larger PanNET size (P = .0089; best threshold 28 mm) and grade 2 PanNET (P = .048), and a pejorative prognostic impact (P = .043). Patients with PV in VHL exon 1 had larger PanNETs (P = .018), more often metastatic disease (48% vs 11.5%; P &lt; .001) and a trend toward shorter OS (P = .16).

Conclusion
The risk of metastases associated with VHL-related PanNETs remains low (24%) but increases with tumor size greater than 28 mm, higher grade, and in case of PV, located in VHL exon 1. These data might help improve the management of these patients, who should be referred to an expert center.
Oncologic Outcomes for Different Axillary Staging Techniques in Patients with Nodal-Positive Breast Cancer Undergoing Neoadjuvant Systematic Treatment: A Cancer Registry Study
Authors: Pfob André , Kokh Daria B. , Surovtsova Irina , Riedel Fabian , Morakis Philipp , Heil Joerg 
Published: May 2024

Abstract
Background
Targeted approaches such as targeted axillary dissection (TAD) or sentinel lymph node biopsy (SLNB) showed false-negative rates of < 10% compared with axillary lymph node dissection (ALND) in patients with nodal-positive breast cancer undergoing neoadjuvant systemic treatment (NAST). We aimed to evaluate real-world oncologic outcomes for different axillary staging techniques.

Methods
We identified nodal-positive breast cancer patients undergoing NAST from 2016 to 2021 from the state cancer registry of Baden-Wuerttemberg, Germany. Invasive disease-free survival (iDFS) was assessed using Kaplan–Meier statistics and multivariate Cox regression models (adjusted for age, ypN stage, ypT stage, and tumor biologic subtype).

Results
A total of 2698 patients with a median follow-up of 24.7 months were identified: 2204 underwent ALND, 460 underwent SLNB (255 with ≥ 3 sentinel lymph nodes [SLNs] removed, 205 with 1–2 SLNs removed), and 34 underwent TAD. iDFS 3 years after surgery was 69.7% (ALND), 76.6% (SLNB with ≥ 3 SLNs removed), 76.7% (SLNB with < 3 SLNs removed), and 78.7% (TAD). Multivariate Cox regression analysis showed no significant influence of different axillary staging techniques on iDFS (hazard ratio [HR] for SLNB with < 3 SLNs removed 0.96, 95% confidence interval [CI] 0.62–1.50; HR for SLNB with ≥ 3 SLNs removed 0.86, 95% CI 0.56–1.3; HR for TAD 0.23, 95% CI 0.03–1.64; ALND reference), and for ypN+ (HR 1.92, 95% CI 1.49–2.49), triple-negative breast cancer (HR 2.35, 95% CI 1.80–3.06), and ypT3-4 (HR 2.93, 95% CI 2.02–4.24).

Conclusion
These real-world data provide evidence that patient selection for de-escalated axillary surgery for patients with nodal-positive breast cancer undergoing NAST was successfully adopted and no early alarm signals of iDFS detriment were detected.
Breath-Hold Diving Injuries — A Primer for Medical Providers
Authors: Yu Elaine , Valdivia-Valdivia Juan M. , Silva Fernando , Lindholm Peter 
Published: May 2024

Abstract
Breath-hold divers, also known as freedivers, are at risk of specific injuries that are unique from those of surface swimmers and compressed air divers. Using peer-reviewed scientific research and expert opinion, we created a guide for medical providers managing breath-hold diving injuries in the field. Hypoxia induced by prolonged apnea and increased oxygen uptake can result in an impaired mental state that can manifest as involuntary movements or full loss of consciousness. Negative pressure barotrauma secondary to airspace collapse can lead to edema and/or hemorrhage. Positive pressure barotrauma secondary to overexpansion of airspaces can result in gas embolism or air entry into tissues and organs. Inert gas loading into tissues from prolonged deep dives or repetitive shallow dives with short surface intervals can lead to decompression sickness. Inert gas narcosis at depth is commonly described as an altered state similar to that experienced by compressed air divers. Asymptomatic cardiac arrhythmias are common during apnea, normally reversing shortly after normal ventilation resumes. The methods of glossopharyngeal breathing (insufflation and exsufflation) can add to the risk of pulmonary overinflation barotrauma or loss of consciousness from decreased cardiac preload. This guide also includes information for medical providers who are tasked with providing medical support at an organized breath-hold diving event with a list of suggested equipment to facilitate diagnosis and treatment outside of the hospital setting.
Przedmojżeszowy kult Jahwe
Authors: Urbański Piotr 
Published: May 2024

Bóg Izraela objawia się Mojżeszowi na górze Synaj pod imieniem Jestem, który jestem oraz Jahwe. Fragmenty biblijne uznawane za najstarsze sugerują, że Jahwe przybywa do Izraelitów z terenów południowej Transjordanii, określanych jako Seir, Teman, Edom, Paran. Pochodzenie kultu Jahwe od Kenitów czy Moabitów zostało wyrażone w teorii kenickiej, która opiera się na roli pochodzącego od Madianitów teścia Mojżesza, Jetro. Wspólne pochodzenie Izraelitów i Edomitów jest kolejną wskazówką za kultem Jahwe na południu poza Izraelem. Spojrzenie mogą pogłębić inskrypcje odkryte w egipskich świątyniach okresu poprzedzającego Wyjście z Egiptu (w Soleb, Amara Zachodnim i Medinet Habu). Zawarta tam forma Yhw utożsamiana z imieniem Boga Izraela pozwala wnioskować, że ludy koczownicze szaszu zamieszkujące pustynię na wshód od Egiptu określały się za pomocą Yhw.
Social media trends in obstetrics and gynecology residency programs on Instagram and X (Twitter)
Authors: Gnade Colette M. , Avery Chace C. , Yang Ziyi , Pickett Charlotte M. , Oshinowo Adeoti E. 
Published: May 2024

Background
During the COVID pandemic, residency program’s social media presence increased to aid in residency recruitment by attempting to increase engagement and readily available information for applicants across specialties. However, little information exists on what characteristics and content on obstetrics and gynecology (OBGYN) residency program accounts attract more followers or engagement.

Objectives
To identify social media trends in OBGYN residencies and determine which aspects of programs influence the number of followers and interaction with content posted.

Methods
We performed a retrospective review of ACGME accredited OBGYN programs and determined their presence on Instagram and X in the fall of 2021. Content from the thirty programs with the most followers was analyzed independently by two authors. Multivariate analysis and a linear mixed model were used to characterize and evaluate content on Instagram and X.

Results
Most programs utilized Instagram (88.5%, N = 262/296) and were managed solely by residents (84.4%, N = 108/128). Number of followers on Instagram positively correlated with features such as program size, Instagram profile duration, and Doximity rankings (p < 0.0x01). Programs on X had more followers if their profile had a longer duration, followed more individuals, or were ranked higher on Doximity. The most posted Instagram content was biographical and social in nature. Instagram posts with the highest engagement were awards and/or the Match.

Conclusions
Understanding what social media content attracts more followers and increases engagement is crucial as it likely impacts OBGYN resident recruitment. Professional groups should establish guidelines for social media use in recruitment for the protection of both residents and applicants.
Classification of trauma-related preventable death; protocol of a Delphi procedure
Authors: Hakkenbrak Nadia A. G. , Harmsen Annelieke M. K. , Zuidema Wietse P. , Reijnders Udo J. L. , Schober Patrick , Bloemers Frank W. 
Published: May 2024

Background
Trauma-related (preventable) death is used to evaluate the management and quality of trauma care worldwide. Therefore, it is necessary to identify fatalities in the trauma care population and assess them on preventability. However, the definition on trauma-related preventable death lacks validity due to differences in terminology and classifications. This study aims to reach consensus on the definition of trauma-related preventable death by performing a Delphi procedure, thereby, improving the assessment of trauma-related preventable death and thereby enhancing the quality of trauma care.

Methods
Based on the results of a recently performed systematic review Hakkenbrak (2021). The definitions used to describe trauma-related preventable death could be divided into four categories: 1) Clinical definition based on panel review or expert opinion, 2) Trauma prediction algorithm, 3) Clinical definition with an additional trauma prediction algorithm and 4) Others (e.g., errors in care or detailed clinical definition). A three round, electronic Delphi study will be performed in the Netherlands to reach consensus. Experts from the department of Trauma surgery, Neurosurgery, Forensic medicine, Anaesthesiology and Emergency medicine, of the designated Level 1 trauma centres in the Netherlands, will be invited to participate. In the first round the panel will comment on the composed categories and trauma prediction algorithms. In the second and third round a feedback report will be presented and the questions with disagreement will be retested.

Discussion
The identification and assessment of trauma-related preventable death is necessary to evaluate and improve trauma care. Therefore, a valid, fair, and applicable definition of trauma-related preventable death is required. The Delphi technique is utilized to reach group consensus to obtain a scientifically valid definition of trauma-related preventable death.
Health-related quality of life in non-alcoholic fatty liver disease: A cross-cultural study between Spain and the United Kingdom
Authors: Funuyet-Salas Jesús , Martín-Rodríguez Agustín , Pérez-San-Gregorio María Ángeles , Vale Luke , Robinson Tomos , Anstee Quentin M. , Romero-Gómez Manuel 
Published: May 2024

Background
It is unclear what biopsychosocial factors influence the impact of NAFLD on health-related quality of life (HRQoL), and if these factors are equally important predictors between different nationalities.

Methods
HRQoL (CLDQ) was measured in both Southern European (Spain, n = 513) and Northern European (United Kingdom -UK-, n = 224) cohorts of patients with NAFLD in this cross-sectional study. For each cohort, participant data were recorded on histological grade of steatohepatitis, stage of fibrosis and biopsychosocial variables. Regression analysis was used to explore which of these variables predicted HRQoL. Moderated mediation models were conducted using SPSS PROCESS v3.5 macro.

Results
Participants with severe fibrosis reported more fatigue, systemic symptoms and worry, and lower HRQoL than those with none/mild fibrosis, regardless of place of origin. In addition, body mass index (BMI) and gender were found to be significant predictors of HRQoL in both Spanish and UK participants. Female gender was associated with worse emotional function, higher BMI and more fatigue, which predicted lower participants’ HRQoL. UK participants showed more systemic symptoms and worry than Spanish participants, regardless of liver severity. The negative effects of gender on HRQoL through emotional function, BMI and fatigue were reported to a greater degree in UK than in Spanish participants.

Conclusions
UK participants showed a greater impairment in HRQoL as compared to Spanish participants. Higher fibrosis stage predicted lower HRQoL, mainly in the Spanish cohort. Factors such as female gender or higher BMI contributed to the impact on HRQoL in both cohorts of patients and should be considered in future multinational intervention studies in NAFLD.