bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-lasting improvements in episodic memory among subjects with mild cognitive impairment who received transcranial direct current stimulation combined with cognitive treatment and telerehabilitation: a multicentre, randomized, active-controlled study
Authors: Manenti Rosa , Baglio Francesca , Pagnoni Ilaria , Gobbi Elena , Campana Elena , Alaimo Cristina , Rossetto Federica , Di Tella Sonia , Pagliari Chiara , Geviti Andrea , Bonfiglio Natale Salvatore , Calabrò Rocco Salvatore , Cimino Vincenzo , Binetti Giuliano , Quartarone Angelo , Bramanti Placido , Cappa Stefano F. , Rossini Paolo Maria , Cotelli Maria 
Published: June 2024

BackgroundIn recent years, an increasing number of studies have examined the potential efficacy of cognitive training procedures in individuals with normal ageing and mild cognitive impairment (MCI).ObjectiveThe aims of this study were to (i) evaluate the efficacy of the cognitive Virtual Reality Rehabilitation System (VRRS) combined with anodal transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex compared to placebo tDCS stimulation combined with VRRS and (ii) to determine how to prolong the beneficial effects of the treatment. A total of 109 subjects with MCI were assigned to 1 of 5 study groups in a randomized controlled trial design: (a) face-to-face (FTF) VRRS during anodal tDCS followed by cognitive telerehabilitation (TR) (clinic-atDCS-VRRS+Tele@H-VRRS); (b) FTF VRRS during placebo tDCS followed by TR (clinic-ptDCS-VRRS+Tele@H-VRRS); (c) FTF VRRS followed by cognitive TR (clinic-VRRS+Tele@H-VRRS); (d) FTF VRRS followed by at-home unstructured cognitive stimulation (clinic-VRRS+@H-UCS); and (e) FTF cognitive treatment as usual (clinic-TAU).ResultsAn improvement in episodic memory was observed after the end of clinic-atDCS-VRRS (p &lt; 0.001). We found no enhancement in episodic memory after clinic-ptDCS-VRRS or after clinic-TAU.Moreover, the combined treatment led to prolonged beneficial effects (clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-ptDCS-VRRS+Tele@H-VRRS: p = 0.047; clinic-atDCS-VRRS+Tele@H-VRRS vs. clinic-VRRS+Tele@H-VRRS: p = 0.06).DiscussionThe present study provides preliminary evidence supporting the use of individualized VRRS combined with anodal tDCS and cognitive telerehabilitation for cognitive rehabilitation.Clinical trial registrationhttps://clinicaltrials.gov/study/NCT03486704?term=NCT03486704&amp;rank=1, NCT03486704.
A novel approach to treating post-stroke depression: administration of Botulinum Toxin A via local facial injection
Authors: Feng Xiao-Yan , Shen Ting-Ting , Wu Qian-Chang , Wang Jun , Ni Ping , Liu Jing , Zhou Xu-Ping , Hu Hua , Luo Wei-Feng 
Published: June 2024

BackgroundPost-stroke depression (PSD) is a frequent complication following a stroke, characterized by prolonged feelings of sadness and loss of interest, which can significantly impede stroke rehabilitation, increase disability, and raise mortality rates. Traditional antidepressants often have significant side effects and poor patient adherence, necessitating the exploration of more suitable treatments for PSD. Previous researchers and our research team have discovered that Botulinum Toxin A (BoNT-A) exhibits antidepressant effects. Therefore, our objective was to assess the efficacy and side effects of BoNT-A treatment in patients with PSD.MethodsA total of 71 stroke patients meeting the inclusion criteria were allocated to the two group. 2 cases were excluded due to severe neurological dysfunction that prevented cooperation and 4 cases were lost follow-up. Ultimately, number of participants in the BoNT-A group (n = 32) and Sertraline group (n = 33). Treatment efficacy was evaluated 1, 2, 4, 8 and 12 weeks post-treatment.ResultsThere were no significant differences in baseline characteristics between the two groups (p &gt; 0.05). Both groups exhibited comparable treatment efficacy, with fewer side effects observed in the BoNT-A group compared to the Sertraline group. BoNT-A therapy demonstrated significant effects as early as the first week (p &lt; 0.05), and by the 12th week, there was a notable decrease in neuropsychological scores, significantly lower than the baseline level. The analysis revealed significant differences in measurements of the Hamilton Depression Scale (HAMD) (F(770) = 12.547, p = 0.000), Hamilton Anxiety Scale (HAMA) (F(951) = 10.422, p = 0.000), Self-Rating Depression Scale (SDS) (F(1385) = 10.607, p = 0.000), and Self-Rating Anxiety Scale (SAS) (F(1482) = 11.491, p = 0.000).ConclusionBoNT-A treatment effectively reduces depression symptoms in patients with PSD on a continuous basis.
Application of novel non-invasive ophthalmic imaging to visualize peripapillary wrinkles, retinal folds and peripapillary hyperreflective ovoid mass-like structures associated with elevated intracranial pressure
Authors: Graven-Nielsen Michaela , Dubra Alfredo , Dodd Robert L. , Hamann Steffen , Moss Heather E. 
Published: June 2024

BackgroundElevated intracranial pressure (ICP) is a serious and potentially life-threatening condition, for which clinically useful non-invasive measures have been elusive, in some cases due to their inadequate sensitivity and specificity. Our aim was to evaluate novel non-invasive ophthalmic imaging of selected pathological features seen in elevated ICP, namely peripapillary hyperreflective ovoid mass-like structures (PHOMS), peripapillary wrinkles (PPW) and retinal folds (RF) as potential biomarkers of elevated ICP.MethodsThis single-center pilot study included subjects with untreated or incompletely treated high ICP. The retinas of these subjects were evaluated with averaged en-face optical coherence tomography (OCT), OCT retinal cross-sections (OCT B-scans), adaptive optics scanning light ophthalmoscopy (AOSLO), and fundus photos.ResultsSeven subjects were included in the study. 6 subjects with high ICP (5 idiopathic intracranial hypertension, 1 medication induced, 30.8 ± 8.6 years, 75% female, 5 with papilledema) and 1 control (20–25 years) were included. PHOMS, PPW and RF were present in all subjects with papilledema, but neither in the high ICP subject without papilledema nor in the control subject. Averaged en-face OCT scans and AOSLO were more sensitive for PPW and RF than OCT B-scans and commercial fundus photos.ConclusionPPW, RF and PHOMS volume have potential as non-invasive biomarkers of ICP. Novel imaging modalities may improve sensitivity. However, lack of automated image acquisition and processing limits current widespread adoption in clinical settings. Further research is needed to validate these structures as biomarkers for elevated ICP and improve clinical utility.
Identification of anoikis-related gene signatures and construction of the prognosis model in prostate cancer
Authors: Kang Wanying , Ye Chen , Yang Yunyun , Lou Yan-Ru , Zhao Mingyi , Wang Zhuo , Gao Yuan 
Published: June 2024

BackgroundOne of the primary reasons for tumor invasion and metastasis is anoikis resistance. Biochemical recurrence (BCR) of prostate cancer (PCa) serves as a harbinger of its distant metastasis. However, the role of anoikis in PCa biochemical recurrence has not been fully elucidated.MethodsDifferential expression analysis was used to identify anoikis-related genes based on the TCGA and GeneCards databases. Prognostic models were constructed utilizing LASSO regression, univariate and multivariate Cox regression analyses. Moreover, Gene Expression Omnibus datasets (GSE70770 and GSE46602) were applied as validation cohorts. Gene Ontology, KEGG and GSVA were utilized to explore biological pathways and molecular mechanisms. Further, immune profiles were assessed using CIBERSORT, ssGSEA, and TIDE, while anti-cancer drugs sensitivity was analyzed by GDSC database. In addition, gene expressions in the model were examined using online databases (Human Protein Atlas and Tumor Immune Single-Cell Hub).Results113 differentially expressed anoikis-related genes were found. Four genes (EEF1A2, RET, FOSL1, PCA3) were selected for constructing a prognostic model. Using the findings from the Cox regression analysis, we grouped patients into groups of high and low risk. The high-risk group exhibited a poorer prognosis, with a maximum AUC of 0.897. Moreover, larger percentage of immune infiltration of memory B cells, CD8 Tcells, neutrophils, and M1 macrophages were observed in the high-risk group than those in the low-risk group, whereas the percentage of activated mast cells and dendritic cells in the high-risk group were lower. An increased TIDE score was founded in the high-risk group, suggesting reduced effectiveness of ICI therapy. Additionally, the IC50 results for chemotherapy drugs indicated that the low-risk group was more sensitive to most of the drugs. Finally, the genes EEF1A2, RET, and FOSL1 were expressed in PCa cases based on HPA website. The TISCH database suggested that these four ARGs might contribute to the tumor microenvironment of PCa.ConclusionWe created a risk model utilizing four ARGs that effectively predicts the risk of BCR in PCa patients. This study lays the groundwork for risk stratification and predicting survival outcomes in PCa patients with BCR.
Exploring the recycled water acceptance based on the technological perspective of UTAUT2: a hybrid analytical approach
Authors: Xu Xiao-Yu , Hu Yi-Bo , Gao Ya-Xuan , Jia Qing-Dan 
Published: June 2024

IntroductionThe development of advanced sewage technologies empowers the industry to produce high-quality recycled water, which greatly influences human’s life and health. Thus, this study investigates the mechanism of individuals’ adoption of recycled water from the technology adoption perspective.MethodsEmploying the mixed method of structural equation modeling and artificial neural network analysis, we examined a research model developed from the extended Unified Theory of Acceptance and Use of Technology (UTAUT2) framework. To examine the research model, this study employs a leading web-survey company (Sojump) to collect 308 valid samples from the residents in mainland China.ResultsThe structural equation modeling results verified the associations between the six predictors (performance expectancy, effort expectancy, social influence, facilitating conditions, environmental motivation, and price value), individuals’ cognitive and emotional attitudes, and acceptance intention. The artificial neural network analysis validates and complements the structural equation modeling results by unveiling the importance rank of the significant determinants of the acceptance decisions.DiscussionThe study provides theoretical implications for recycled water research and useful insights for practitioners and policymakers to reduce the environmental hazards of water scarcity.
Drug–drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics
Authors: Zhang Cun , Jiang Lei , Hu Ke , Zhang Yi-Jia , Han Jing , Chen Jin , Bulubu  , Dong Boling , Shi Hao-Zhe , He Su-Mei , Yu Ting-Ting , Chen Xiao , Wang Dong-Dong 
Published: June 2024

BackgroundThe present study aimed to investigate the drug–drug interaction and initial dosage optimization of aripiprazole in patients with schizophrenia based on population pharmacokinetics.Research design and methodsA total of 119 patients with schizophrenia treated with aripiprazole were included to build an aripiprazole population pharmacokinetic model using nonlinear mixed effects.ResultsThe weight and concomitant medication of fluoxetine influenced aripiprazole clearance. Under the same weight, the aripiprazole clearance rates were 0.714:1 in patients with or without fluoxetine, respectively. In addition, without fluoxetine, for the once-daily aripiprazole regimen, dosages of 0.3 and 0.2 mg kg−1 day−1 were recommended for patients with schizophrenia weighing 40–95 and 95–120 kg, respectively, while for the twice-daily aripiprazole regimen, 0.3 mg kg−1 day−1 was recommended for those weighing 40–120 kg. With fluoxetine, for the once-daily aripiprazole regimen, a dosage of 0.2 mg kg−1 day−1 was recommended for patients with schizophrenia weighing 40–120 kg, while for the twice-daily aripiprazole regimen, 0.3 and 0.2 mg kg−1 day−1 were recommended for those weighing 40–60 and 60–120 kg, respectively.ConclusionThis is the first investigation of the effects of fluoxetine on aripiprazole via drug–drug interaction. The optimal aripiprazole initial dosage is recommended in patients with schizophrenia.
Biopotential of rhizobacteria to improve growth and phytochemical content in Javanese ginseng (Talinum paniculatum) herbal plant
Authors: Suriani Ni Luh , Suprapta Dewa Ngurah , Suarsana I. Nyoman , Resiani Ni Made Delly , Perveen Kahkashan , Bukhari Najat A. , Ei Enshasy Hesham Ali , Ho Ting Seng , Sayyed R. Z. 
Published: June 2024

IntroductionDeveloping organic herbal crops provides chemical-free herbs to support environmentally friendly and sustainable farming. One way in agricultural biotechnology to grow herbal organic crops is to use rhizobacteria. The herbal plant used in this study is the Javanese ginseng plant (Talinum paniculatum), which contains phytochemicals that increase stamina.MethodsThe study used four rhizobacteria to enhance the growth and phytochemistry of T. paniculatum leaves; the target phytochemical compounds analyzed in Javanese ginseng leaves were total flavonoids, total phenols, and antioxidants (IC50%). The four selected rhizobacteria can produce indole-3-acetic acid (IAA), fix nitrogen, and dissolve phosphate. Thus, high-quality T. paniculatum leaves were obtained as herbal tea ingredients. The pattern used is a random group pattern in the greenhouse.ResultsThe results of the study showed that the use of rhizobacteria at 2% concentrations had a real effect on plant growth parameters such as plant height, leaf area, root length, wet weight and dry weight of the plant, and phytochemical content like total flavonoids, total phenols, IC50%, total chlorophyll, content of T. paniculatum leave plant when compared to the control. The four rhizobacteria used can produce the IAA, fix nitrogen, and dissolve phosphorus.DiscussionThe four rhizobacteria can also colonize the root of the T. paniculatum plant. The four Rhizobzcteria used significantly affected the growth and phytochemical content of T. paniculatum leaves as an ingredient in herbal tea at a concentration of 2% compared to controls. The four rhizobacteria can produce IAA hormones, fix nitrogen, and dissolve phosphorus. All four rhizobacteria can colonize the roots of T. paniculatum plants. These four rhizobacteria can be used as alternative methods in developing organic farming systems and can also be used practically in the field by farmers. It is necessary to research the application of rhizobacteria to other crops to support sustainable agriculture.
Efeitos sonoros a partir de arcos voltaicos
Authors: Júnior José Milton Ferreira , Silva Rafael Maciel da , Brito Jéssyca de Freitas Lima , Bezerra Bruna Tarciana Cavalcante , Silva Suely Alves 
Published: June 2024

Os conteúdos estudados na engenharia elétrica, em específico na disciplina de eletromagnetismo, apresentam um alto nível de abstração, tornando o aprendizado complexo e, por vezes, com baixo rendimento de aprendizado. Nesse contexto, o presente trabalho traz uma proposta de construção e abordagem didática de uma máquina de arcos voltaicos baseada na bobina de Tesla, que, por meio de interações sonoras associadas às suas frequências, visa apresentar os conceitos teóricos de forma prática e lúdica, tornando o conteúdo mais plausível e verossímil. Destarte, este estudo tem como objetivo apresentar, a partir de uma abordagem experimental, a teoria da indução eletromagnética, os aspectos teóricos e práticos envolvidos na elaboração e execução do projeto descrito, além de propor métodos de abordagem e avaliação formativa que buscam o desenvolvimento da autonomia e da participação ativa e cooperativa do estudante.
REFORMING THE LICENSING STRUCTURE IN THE FIELD OF TELECOMMUNICATIONS IN THE RUSSIAN FEDERATION
Authors: Пальцин Д.А. , Пшеничников А.П. 
Published: June 2024

Рассмотрены основные тенденции мировой практики лицензирования в сфере телекоммуникаций и проведен анализ состояния лицензирования услуг связи в РФ в условиях глубокой технологической модернизации отрасли. В порядке обсуждения предложен ряд мер по приведению лицензионных требований в соответствие со сложившейся структурой сети электросвязи РФ и перспективными направлениями ее развития.
The main trends in the global practice of licensing in the field of telecommunications are considered, and the analysis of the state of licensing of communication services in the Russian Federation in the context of deep technological modernization of the industry is carried out. As a matter of discussion, a number of measures have been proposed to bring licensing requirements in line with the current structure of the telecommunications network of the Russian Federation and promising areas of its development.
ПРОБЛЕМИ РЕКОНСТРУКЦІЇ ТА ЗНАЧЕННЯ СЛОВ’ЯНСЬКИХ МУЗИЧНИХ ІНСТРУМЕНТІВ У ДУХОВНІЙ КУЛЬТУРІ СЕРЕДНЬОВІЧНОЇ ЄВРОПИ
Authors: Зінків Ірина 
Published: June 2024

Стаття присвячена вивченню особливостей форми та морфології середньовічних музичних інструментів слов’янського світу, які можуть вказувати на конкретні ретроспективні напрями пошуків їх вихідних прототипів, що виокремлюються на основі типологічно спільних ознак. Уведено до наукового обігу нові музичні інструменти з археологічних розкопок на території розселення середньовічних слов’ян. Проведено реконструкцію окремих середньовічних музичних інструментів, спираючись на їх генетично споріднені синхронні та діахронні аналоги.Здійснений порівняльний аналіз дозволяє переглянути усталену думку (чи навіть теорію) про вихідні прототипи окремих різновидів музичного інструментарію слов’янського світу.
ПРОБЛЕМИ ПРОФЕСІЙНОСТІ ХОРОВОГО МИСТЕЦТВА НА СТОРІНКАХ ЧАСОПИСУ «УКРАЇНСЬКА МУЗИКА» 1937–1939 РОКІВ
Authors: Майчик Остап 
Published: June 2024

Висвітлено проблемні питання професійності хорового співу в Галичині крізь оптику змістового наповнення статей часопису «Українська музика», що виходив неповних три роки у Львові наприкінці 1930-х р. Чимало публікацій галицьких музикознавців, композиторів і виконавців (піаністів, вокалістів, диригентів) присвячені хоровому мистецтву, яке було тоді наймасовішим і охоплювало різні життєві сфери – такі як побутове дозвілля, концертні виступи, супровід Богослужінь, національно-громадські заходи, музичне шкільництво тощо. Проаналізовано статті визначних представників вокально-хорової галузі М. Антоновича, Б. Пюрка, Є. Лисько, якими виявлено низку недоліків і запропоновано способи їх подолання.
VSEP membrane technology for glycol regeneration through the example of waste airport de-icing fluids (part 2)
Authors: Цабилев О.В. 
Published: June 2024

Приводятся результаты серии длительных пилотных испытаний VSEP – технологии вибромембранного разделения отработанных загрязненных растворов гликольсодержащих жидкостей с использованием мембран нанофильтрации. Испытания проводились на базе одной из научно-производственных компаний, расположенной в Центральном федеральном округе России. В качестве жидкости для исследований использовалась смесь отработанных загрязненных растворов противообледенительных жидкостей, собираемых в крупных аэропортах в холодный период года. В ходе испытаний получены положительные результаты, поэтому технология может быть рекомендована к промышленной реализации. Процесс разделения отличается стабильностью, а качество очищенной жидкости соответствует самым высоким требованиям. Особенностью исследуемой технологии является простота реализации, практически полное отсутствие реагентов и компактность оборудования, что делает возможным реализовать локальные системы очистки растворов гликольсодержащих жидкостей.
The results of a series of long-term pilot tests of the VSEP technology for vibromembrane separation of waste contaminated solutions of glycol-containing fluids using nanofiltration membranes are presented. The tests were carried out on the basis of one of the research and production companies located in the Central Federal District of Russia. A mixture of waste contaminated solutions of de-icing fluids collected at large airports during the cold season of the year was used as research liquid. He studies have shown positive results, so the technology can be recommended for industrial application. The separation process is stable, and the quality of the effluent meets the most stringent requirements. A feature of the technology under study is its ease of use, the almost complete elimination of chemicals and the compactness of the equipment, which makes it possible to design local systems for the purification of solutions of glycol-containing liquids.
The use of active carbons in wastewater treatment of oil refineries
Authors: Цуканова А.Н. , Глушанкова И.С. , Фарберова Е.А. , Перевозчикова Е.А. , Кузьмин А.В. 
Published: June 2024

Рассмотрена возможность замены активного угля из кокосового сырья активным углем из ископаемого каменного угля на примерах торговых марок КАУСОРБ и ДАУСОРБ (производства АО «Сорбент», г. Пермь) для применения в напорных углесорбционных фильтрах для доочистки нефтесодержащих сточных вод, образующихся в системе замкнутого водоснабжения на нефтеперерабатывающих предприятиях. Исследованы особенности использования исследуемых активных углей в углесорбционных фильтрах. Установлено, что активные угли из каменноугольного сырья обеспечивают глубокую очистку сточных вод от органических примесей, при этом увеличивается ресурс эксплуатации сорбционных фильтров на 25–30%.
Possible replacing activated carbon made of coconut raw materials with active carbon made of fossil coal is considered using the examples of the KAUSORB and DAUSORB trademarks (produced by Sorbent JSC, Perm) for using in pressure carbon sorption filters for the tertiary treatment of oil-containing wastewater generated in a closed water supply system at oil refineries. The features of using the studied active carbons in carbon sorption filters have been studied. It has been established that activated carbons made of coal-tar raw materials provide for the enhanced removal of organic pollutants from wastewater; herewith, the service life of sorption filters increases by 25–30%.