bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiomyocyte-specific deletion of the mitochondrial transporter Abcb10 causes cardiac dysfunction via lysosomal-mediated ferroptosis
Authors: Do Yura , Yagi Mikako , Hirai Haruka , Miki Kenji , Fukahori Yukina , Setoyama Daiki , Yamamoto Masatatsu , Furukawa Tatsuhiko , Kunisaki Yuya , Kang Dongchon , Uchiumi Takeshi 
Published: April 2024

Abstract
Heart function is highly dependent on mitochondria, which not only produce energy but also regulate many cellular functions. Therefore, mitochondria are important therapeutic targets in heart failure. Abcb10 is a member of the ABC transporter superfamily located in the inner mitochondrial membrane and plays an important role in haemoglobin synthesis, biliverdin transport, antioxidant stress, and stabilization of the iron transporter mitoferrin-1. However, the mechanisms underlying the impairment of mitochondrial transporters in the heart remain poorly understood. Here, we generated mice with cardiomyocyte-specific loss of Abcb10. The Abcb10 knockouts exhibited progressive worsening of cardiac fibrosis, increased cardiovascular risk markers and mitochondrial structural abnormalities, suggesting that the pathology of heart failure is related to mitochondrial dysfunction. As the mitochondrial dysfunction was observed early but mildly, other factors were considered. We then observed increased Hif1α expression, decreased NAD synthase expression, and reduced NAD+ levels, leading to lysosomal dysfunction. Analysis of ABCB10 knockdown HeLa cells revealed accumulation of Fe2+ and lipid peroxides in lysosomes, leading to ferroptosis. Lipid peroxidation was suppressed by treatment with iron chelators, suggesting that lysosomal iron accumulation is involved in ferroptosis. We also observed that Abcb10 knockout cardiomyocytes exhibited increased ROS production, iron accumulation, and lysosomal hypertrophy. Our findings suggest that Abcb10 is required for the maintenance of cardiac function and reveal a novel pathophysiology of chronic heart failure related to lysosomal function and ferroptosis.
Multi‐mode converter control for linear generator‐based wave energy system
Authors: Ullah Md Imran , Döhler Jessica S. , de Albuquerque Vinicius M. , Forslund Johan , Boström Cecilia , Temiz Irina 
Published: April 2024

AbstractThe electrification of remote islands has long been a subject of research interest, primarily because of their historical reliance on fossil fuels, leading to a significant carbon footprint. Recent advancements in wave energy converters offer a promising avenue to make these islands more self‐sustainable while considerably reducing carbon emissions. However, the persistent issue of voltage dips due to weaker grids continues to pose a challenge. This study introduces a multi‐mode converter control strategy with the goal of electrifying remote islands, employing a linear generator‐based wave energy converter in a unified electrical model. Various scenarios, including voltage dips and mainland grid disconnection, are simulated using MATLAB/Simulink. The study demonstrates the converter's ability to transition swiftly and smoothly in response to these scenarios, ensuring an uninterrupted power supply. Furthermore, the analysis indicates that the power quality at the point of common coupling remains well within acceptable standards.
PDS 70 unveiled by star-hopping: Total intensity, polarimetry, and millimeter imaging modeled in concert
Authors: Wahhaj Z. , Benisty M. , Ginski C. , Swastik C. , Arora S. , van Holstein R. G. , De Rosa R. , Yang B. , Bae J. , Ren B. 
Published: April 2024

Context. Most ground-based direct-imaging planet search campaigns use angular differential imaging that distorts the signal from extended sources, such as protoplanetary disks. In the case of the young system PDS 70, for which two planets were detected within the cavity of a protoplanetary disk, obtaining a reliable image of both planets and the disk is essential to understanding planet-disk interactions.
Aims. Our goals are to reveal the true intensity of the planets and disk without self-subtraction effects for the first time, search for new giant planets beyond separations of 0.1″, and to study the morphology of the disk shaped by two massive planets.
Methods. We present YJHK-band imaging, polarimetry, and spatially resolved spectroscopy of PDS 70 using near-simultaneous reference star differential imaging, also known as star-hopping. We created a radiative transfer model of the system to try to match the near-infrared imaging and polarimetric data within measurement errors. Sub-millimeter imaging data from ALMA were also modeled. Furthermore, we extracted the spectra of the planets and the disk and compared them
Results. With strong constraints, we find that the disk is quite flared, with a scale height of ∼15 at the outer edge of the disk at ∼90 au, similar to some disks in the literature. The gap inside ∼50 au is estimated to have ∼1 of the dust density of the outer disk. The northeast outer disk arc seen in previous observations is likely the outer lip of the flared disk. Abundance ratios of sub-micron, micron, and grains estimated by the modeling indicate a shallow grain-size index greater than −2.7, instead of the canonical –3.5. There is both vertical and radial segregation of grains. Planet c is well separated from the disk and has a spectrum similar to planet b, and it is clearly redder than the disk spectra. Planet c is possibly associated with the sudden flaring of the disk starting at ∼50 au. We found no new planets in the system. If we assume DUSTY models and an age of 5 Myr, this indicates no new planets more massive than 5 outside a 12 au separation.
Combined spin orientation and phase function of asteroids
Authors: Carry B. , Peloton J. , Le Montagner R. , Mahlke M. , Berthier J. 
Published: April 2024

Context. Large sky surveys provide numerous non-targeted observations of small bodies of the Solar System. The upcoming LSST of the Vera C. Rubin Observatory will be the largest source of small body photometry in the next decade. With non-coordinated epochs of observation, colors – and therefore taxonomy and composition – can only be computed by comparing absolute magnitudes obtained in each filter by solving the phase function (evolution of brightness of the small body against the solar phase angle). Current models in use in the community (HG, HG12*, and HG1G2), however, fail to reproduce the long-term photometry of many targets due to the change in the aspect angle between apparitions.
Aims. We aim to derive a generic yet simple phase function model accounting for the variable geometry of the small bodies over multiple apparitions.
Methods. As a spinoff of the HG1 G2 model, we propose the sHG1G2 phase function model in which we introduce a term describing the brightness changes due to spin orientation and polar oblateness. We applied this new model to 13 245 908 observations of 122 675 Solar System objects (SSOs). These observations were acquired in the g and r filters with the Zwicky Transient Facility between November 1, 2019 and December 1, 2023. We retrieved them and implemented the new sHG1G2 model in FINK, a broker of alerts designed for the LSST.
Results. The sHG1G2 model leads to smaller residuals than other phase function models, providing a better description of the photometry of asteroids. We determined the absolute magnitude, H, and phase function coefficients (G1, G2) in each filter, the spin orientation (α0, δ0), and the polar-to-equatorial oblateness, R, for 95 593 SSOs, which constitutes about a tenfold increase in the number of characterized objects compared to the current census.
Conclusions. The application of the sHG1 G2 model to ZTF alert data using the FINK broker shows that the model is appropriate for extracting physical properties of asteroids from multi-band and sparse photometry, such as the forthcoming LSST survey.
Risiken für Heranwachsende bei einer frühen Spezialisierung für eine
Sportart
Authors: Johnson Amanda 
Published: April 2024

ZusammenfassungIst es sinnvoll, Heranwachsende schon früh auf eine Sportart festzulegen? Sind Kinder, die sich von klein
auf spezialisiert haben, die späteren Sieger? Haben sie ein höheres Verletzungsrisiko? Oder scheitern sie
gar, weil sich ihr Körper schneller abnutzt? Amanda Johnson hat Antworten auf Fragen, die viele Eltern
und Trainer beschäftigen.
Neurogene, nicht-obstruktive Harnretention: Diagnose und Therapie
Authors: Kaufmann Albert , Leitner Lorenz 
Published: April 2024

Zusammenfassung
Die Ätiologie der neurogenen, nicht-obstruktiven Harnretention ist mannigfaltig. Neben zentralnervösen Erkrankungen kommen auch Erkrankungen des peripheren Nervensystems in Betracht. Die Restharnbildung kann zu erheblichen Problemen führen, die die Patient*innen in ihrem täglichen Leben enorm beeinflussen können. Nur eine differenzierte Diagnostik macht eine der Harnblasenfunktionsstörung und auch der Lebenssituation der Patient*innen angepasste Therapie möglich. Sowohl konservative als auch operative therapeutische Strategien stehen zur Verfügung, medikamentöse Therapieansätze treten in den Hintergrund.

Als kausale Therapie der Funktionsstörung sind insbesondere neuromodulative Verfahren geeignet. Wenn eine artifizielle Harnblasenentleerung notwendig wird, sollte der intermittierende Selbstkatheterismus wenn immer möglich einem Dauerkatheter vorgezogen werden.
Exploring the Two-Way Link between Migraines and Venous Thromboembolism: A Bidirectional Two-Sample Mendelian Randomization Study
Authors: Wang Yang , Hu Xiaofang , Wang Xiaoqing , Li Lili , Lou Peng , Liu Zhaoxuan 
Published: April 2024

Background The objective of this study is to utilize Mendelian randomization to scrutinize the mutual causality between migraine and venous thromboembolism (VTE) thereby addressing the heterogeneity and inconsistency that were observed in prior observational studies concerning the potential interrelation of the two conditions.
Methods Employing a bidirectional Mendelian randomization approach, the study explored the link between migraine and VTE, incorporating participants of European descent from a large-scale meta-analysis. An inverse-variance weighted (IVW) regression model, with random-effects, leveraging single nucleotide polymorphisms (SNPs) as instrumental variables was utilized to endorse the mutual causality between migraine and VTE. SNP heterogeneity was evaluated using Cochran's Q-test and to account for multiple testing, correction was implemented using the intercept of the MR-Egger method, and a leave-one-out analysis.
Results The IVW model unveiled a statistically considerable causal link between migraine and the development of VTE (odds ratio [OR] = 96.155, 95% confidence interval [CI]: 4.342–2129.458, p = 0.004), implying that migraine poses a strong risk factor for VTE development. Conversely, both IVW and simple model outcomes indicated that VTE poses as a weaker risk factor for migraine (IVW OR = 1.002, 95% CI: 1.000–1.004, p = 0.016). The MR-Egger regression analysis denoted absence of evidence for genetic pleiotropy among the SNPs while the durability of our Mendelian randomization results was vouched by the leave-one-out sensitivity analysis.
Conclusion The findings of this Mendelian randomization assessment provide substantiation for a reciprocal causative association between migraine and VTE within the European population.
The environmental impact of small-bowel capsule endoscopy
Authors: Pioche Mathieu , Cunha Neves Joao A. , Pohl Heiko , Lê Minh-Quyen , Grau Raphaelle , Dray Xavier , Yzet Clara , Mochet Mikael , Jacques Jérémie , Wallenhorst Timothée , Rivory Jérôme , Siret Nadège , Peillet Anne-Laure , Chevaux Jean-Baptiste , Mion François , Chaput Ulriikka , Jacob Philippe , Grinberg Daniel , Saurin Jean-Christophe , Baddeley Robin , Rodriguez de Santiago Enrique , Cottinet Pierre-Jean ,   and the Sustainability Committee of the French Endoscopy Society (SFED)
Published: April 2024

Introduction The environmental impact of endoscopy, including small-bowel capsule endoscopy (SBCE), is a topic of growing attention and concern. This study aimed to evaluate the greenhouse gas (GHG) emissions (kgCO2) generated by an SBCE procedure.
Methods Life cycle assessment methodology (ISO 14040) was used to evaluate three brands of SBCE device and included emissions generated by patient travel, bowel preparation, capsule examination, and video recording. A survey of 87 physicians and 120 patients was conducted to obtain data on travel, activities undertaken during the procedure, and awareness of environmental impacts.
Results The capsule itself (4 g) accounted for < 6 % of the total product weight. Packaging (43–119 g) accounted for 9 %–97 % of total weight, and included deactivation magnets (5 g [4 %–6 %]) and paper instructions (11–50 g [up to 40 %]). A full SBCE procedure generated approximately 20 kgCO2, with 0.04 kgCO2 (0.2 %) attributable to the capsule itself and 18 kgCO2 (94.7 %) generated by patient travel. Capsule retrieval using a dedicated device would add 0.98 kgCO2 to the carbon footprint. Capsule deconstruction revealed materials (e. g. neodymium) that are prohibited from environmental disposal; 76 % of patients were not aware of the illegal nature of capsule disposal via wastewater, and 63 % would have been willing to retrieve it. The carbon impact of data storage and capsule reading was negligible.
Conclusion The carbon footprint of SBCE is mainly determined by patient travel. The capsule device itself has a relatively low carbon footprint. Given that disposal of capsule components via wastewater is illegal, retrieval of the capsule is necessary but would likely be associated with an increase in device-related emissions.
Knowledge of Tobacco Cessation among Adult Patients Visiting a Rural Satellite Center: A Cross-Sectional Study
Authors: Abranches Sergio Atanazio Aurobindo Garcia , Bhat Supriya , Kumari Deesha , Shetty Sankalpa 
Published: April 2024

AbstractThe prevalence of all types of tobacco use among men has been reported to be high in most parts of India (generally exceeding 50%). Nearly 95 to 100% of tobacco users develop periodontal diseases that have a diminishing effect on oral health.A structured paper-based self-administered questionnaire comprising 15 close-ended questions was formulated for the purpose of data collection for this cross-sectional survey and a sample size of 323 was estimated. Total enumeration sampling method was followed. A significant gender-wise and socioeconomic-status-wise difference was observed based on the form of tobacco used. In this cross-sectional study, 54 (16.7%) individuals began the habit before the age of 15 years, of which 14.2% of the individuals used the smoked variant and 2.4% of the individuals used the smokeless variant of tobacco.Total 265 (82%) individuals were aware that the habit was injurious to their health, of which 90% males and 86.4% females were aware of the harmful effects of the habit. While the awareness among the upper socioeconomic group was higher, the lower socioeconomic group displayed a lower level of awareness.To advocate effective tobacco cessation programs, understanding the dependence on tobacco habit and their knowledge and attitude toward quitting tobacco plays a major role. Hence the present study was conducted with an objective to assess the knowledge and attitude of the patients toward tobacco cessation.
Social Disadvantage and Inequity in Access to Pediatric Critical Care Services for Children Living Remote from a Children's Hospital
Authors: Klein Jordan L. , Spaeder Michael C. , Doshi Ayush , Fang Gary Y. , Carver Deborah Jeannean 
Published: April 2024

AbstractRegionalization of health care has created geographical distance between pediatric specialty services and children, with the potential for disparities in access to care. We investigated the association of state-level area deprivation index (S-ADI), a measure of socioeconomic disadvantage, and characteristics and outcomes in a cohort of children requiring unplanned hospital transfer to a quaternary care pediatric intensive care unit (PICU). We conducted a single-center retrospective cohort study of children requiring unplanned hospital transfer to the PICU at the University of Virginia Children's Hospital from July 1, 2019 to December 31, 2020, excluding planned transfers, transfers from another intensive care unit, and patients whose address could not be associated with an S-ADI. We collected demographic and clinical data as well as the S-ADI, an ordinal variable ranging from 1 to 10 with 10 representing the most disadvantage. We observed no differences in S-ADI based on patient sex, age, history of chronic medical conditions, or need for a medical device (tracheostomy, home ventilator, surgical feeding tube, cerebrospinal fluid shunt). We also did not observe differences in PICU or hospital length of stay based on S-ADI. We did observe for every one-point increase in S-ADI there was an associated increase of 8.6 miles (p < 0.001) in patient travel distance. Among patients from a higher S-ADI area, we observed increased severity of illness on PICU admission (p = 0.02) and case fatality as compared with patients from a lower S-ADI area (11 vs. 1.9%, p = 0.038). Children traveling the farthest for subspeciality pediatric critical care at our hospital had higher measures of socioeconomic disadvantage and severity of illness.
TiO2 multi-leg nanotubes for surface-enhanced Raman scattering
Authors: S Harini , Gupta Garima , Roy Somnath C , Yalavarthi Rambabu 
Published: April 2024

Abstract
In the recent past, significant research efforts have been put forth to fabricate cost-effective substrates for surface-enhanced Raman scattering (SERS) applications. Here we propose semiconducting TiO2 multi-leg nanotubes and Au nanoparticle-coated TiO2 multi-leg nanotubes (TiO2 MLNTs and Au/TiO2 MLNTs) as SERS substrates. The unique multi-leg architecture of TiO2 nanotubes demonstrated enhanced light-harvesting properties facilitated by an induced photonic absorption edge. Remarkable high SERS sensitivity is observed towards the detection of Methylene blue (MB), up to nM concentration (E.F. ∼104) using TiO2 MLNTs. The same is attributed to the resonantly matched photonic absorption edge of TiO2 MLNTs with the wavelength of incident laser probe light. On the other hand, the Au nanoparticle coating further leveraged the light absorption ability of TiO2 MLNTs with the aid of localized surface plasmon resonance mode. As such, Au/TiO2 MLNTs showed excellent enhancement in SERS sensitivity (E.F. ∼105
, for nM of MB) facilitated by the synergy between the plasmonic modes of Au and the photonic absorption mode of TiO2 MLNTs. UV-Vis diffuse reflectance and Raman spectroscopy measurements are highlighted to elucidate the light absorption and SERS sensitivity of the TiO2 and Au/TiO2 MLNTs.
Dual mode spin to charge conversion using inverse spin Hall effect in NiFe/FeMn/NiFe multilayer thin films
Authors: Panigrahi Brahmaranjan , Raja M Manivel , Murapaka Chandrasekhar , Haldar Arabinda 
Published: April 2024

Abstract
Microwave devices with more than one operating frequency and their ease of tunability are of great importance for high-frequency information processing. Magnetic thin films offer an unparalleled advantage of engineering different microwave bands that can be precisely tailored and reconfigured externally. Here, novel trilayer structures consisting of NiFe/FeMn/NiFe with varying antiferromagnetic FeMn layer thickness have been investigated by exploring their ferromagnetic resonance (FMR) properties and inverse spin Hall effect (ISHE) responses. Two-step magnetic hysteresis loops are observed for higher FeMn thickness (t ⩾ 12 nm), where the bottom NiFe layer shows a comparatively more significant shift due to the presence of strong interfacial exchange coupling. FMR study reveals two resonant modes associated with the two ferromagnetic layers, which are distinguishable for higher thicknesses of FeMn or at high excitation frequencies. The choice of FeMn thickness determines the operating frequencies, which can be finely tailored by optimizing the FeMn thickness. Gilbert damping parameter is found to be in the range of 0.009–0.012 where the presence of exchange bias adds to the the scattering mechanisms. Prominent ISHE responses are obtained from the bottom NiFe layer as compared to the top NiFe layer. Variation of FeMn thickness also shows a strong influence on the spin pumping (

V

sp

), and perpendicular anisotropic magnetoresistance (

V

AMR

⊥

) components. The results are correlated with the efficiency of spin flow and spin-to-charge conversion of the FeMn layer. Our systems can be used as an emerging alternative for microwave detectors and microwave energy harvesters.
In situ growth of Ag nanoparticles on the surface of MXene by γ-ray irradiation to fabricate EVA composite: the improvement of flame retardancy, smoke suppression, and mechanical properties
Authors: Xu Siyi , Li Danyi , Wang Wenrui , Lin Lin , Sun Ying , Li Jihao , Li Linfan 
Published: April 2024

Abstract
A large amount of toxic smoke and heat generated by the combustion of ethylene vinyl acetate copolymer (EVA) poses a significant threat to human fire escape evacuation. This work aims to use γ-ray to prepare e-MXene@Ag hybrid flame-retardant materials by the method of in-situ reduction, and EVA composites are prepared by melt blending to reduce the smoke and toxic gases produced during combustion significantly. Compared with pure EVA, the total heat release, total smoke release, and the production rate of CO and CO2 produced by the combustion of EVA composite with 1 wt% e-MXene@Ag1.0 decreased by 30.3%, 33.3%, 18.2%, and 20.1% respectively. The fire hazard reduction of EVA composite materials was due to the physical barrier, catalytic carbonization and adsorption of the e-MXene@Ag1.0 hybrid. In addition, e-MXene@Ag1.0 can also further increase the mechanical properties of EVA composites due to its own ‘multi-contact point limit structure’.
Analysis of defects dominating carrier recombination in CeO2 single crystal for photocatalytic applications
Authors: Zhang Endong , Brabec Christoph J , Kato Masashi 
Published: April 2024

Abstract
In photocatalytic water splitting and CO2 reduction, recently, cerium oxide (CeO2) has been widely investigated. Defects that can directly dominate carrier recombination are essential for the photocatalytic performance of CeO2. In this study, several photoluminescence (PL) peaks are observed on the (100) face of an undoped CeO2 single crystal, indicating the presence of defects. Moreover, we characterize carrier recombination using time-resolved photoluminescence (TR-PL) and microwave photoconductivity decay (μ-PCD) measurements. The temperature dependence of decay curves is the result of carrier trapping and emission at deep levels. These decay curves are observed separately using a 565 nm band-pass filter (BPF) based on the PL spectra. The trap energy level (

E

T

) and majority carrier capture cross-section (

σ

T

) of each defect are also analyzed using rate equations to fit the experimental results. The temperature-dependent time constants are well reproduced by a recombination model using hole traps HTinfrared and HTvisible at

E

T

of 0.76 and 0.55 eV from the conduction or valence band, with estimated

σ

T

of the order of 10−21 and 10−22 cm2 for without and with the BPF, respectively. These findings regarding the presence of multiple defects in a single crystal indicate the necessity to focus on defect control.