bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zhonghongite, Cu29(As,Sb)12S33, a new mineral from the high-sulfidation vein of Jiama porphyry system, Tibet, China
Authors: Zheng Shi-Ji , Gu Xiang-Ping , Bai Zhong-Jie , Zhang Zhong-Kun 
Published: May 2024

Abstract
Zhonghongite (IMA2023-046), ideally Cu29(As,Sb)12S33, is a new mineral discovered in the high-sulfidation vein of the Jiama deposit (E 91°45′, N 29°42′), southern Tibet, China. It forms complex intergrowths with watanabeite and tennantite-tetrahedrite, creating veined or massive aggregates ranging from millimeters to centimeters. Single crystals of zhonghongite are anhedral, and their sizes range from several micrometers to ∼100 μm. The mineral is gray with a black streak and metallic luster. It is brittle, with uneven fractures, and has a calculated density of 4.925 g/cm3. The average values of electron microprobe analyses (wt%) are: Cu 42.19, As 11.11, Sb 16.09, S 25.45, Hg 3.73, Mn 0.67, and Te 0.28. The empirical formula, based on 33 sulfur apfu, is (Cu27.60Hg0.77Mn0.51Fe0.07Ag0.02)Σ28.97(As6.16Sb5.49Te0.09)Σ11.74S33. In zhonghongite, the substitution of Sb for As is limited, with the atomic ratio of As/(As+Sb) ranging from 0.457 to 0.629. Hg, Mn, and Fe, with minor Cu, are divalent and serve for charge balance. Zhonghongite is orthorhombic, space group F2mm (42), a = 10.37741(5) Å, b = 14.69821(9) Å, c = 36.7645(2) Å, and V = 5607.66(5) Å3. The crystal structure was solved and refined by single-crystal X-ray diffraction with a final R1 = 0.0235 for 27 028 (2467 unique) reflections. It is composed of individual AsS3 tripyramids and clustered As4S7 tripyramids, CuS4 tetrahedra, and CuS3 planar triangles, connected through corner S atoms in tetrahedral coordination and octahedral coordination with Cu and/or As. The structure is a derivative of a tetrahedrite-type structure. Zhonghongite was formed under high-temperature conditions and is classified as an intermediate-sulfidation state mineral.
Effects of rainfall pattern classification methods on the probability estimation of typhoon-induced debris-flow occurrence
Authors: Bai Zhixu , Yang Youjian , Guo Lin , Lin Leman 
Published: May 2024

ABSTRACT

The frequent occurrence of typhoons causes geological disasters, such as debris flow and landslide, by bringing extreme rainfall events. Due to the lack of data collection on extreme rainfall events caused by typhoons, the relationship between rainfall patterns and debris flow has not been deeply studied. Therefore, based on hourly rainfall data during typhoons in Wenzhou from 1980 to 2017, this study used a variety of methods to classify the rainfall events and analyze the characteristics of typhoon-induced rainfall events and their impacts on the probability of debris-flow occurrence. Three classification techniques, including dynamic time warping, K-Means cluster, and self-organizing maps, are applied with two ways to normalize rainfall records, including dimensionless rainfall density curves and dimensionless rainfall cumulation curves, for extracting rainfall patterns from recorded 1 h rainfall data. The rainfall patterns are then used for the estimation of typhoon-induced debris-flow occurrence probability. Results show that different methods present different rainfall patterns. The probability of debris flows varies with different patterns of rainfall events. The research results help deepen the understanding of typhoon rainfall events and debris-flow disaster prevention in the region and contribute to regional flood control and disaster reduction.
Humic Acid Derived from Agricultural Biomass Mitigates Alveolar Bone Loss and Modulates Systemic Inflammatory Cytokines in Rats with Periodontitis
Authors: Orlando Patrícia Ribeiro , Tavares Hugo Giordano , de Souza Pereira Ramona Ramalho , Silva Gabriela , do Carmo Lima Carvalho Jaqueline , Machado Alan Rodrigues Teixeira , Dobbss Leonardo Barros , Peixoto Marco Fabrício Dias , Pereira Luciano Jose , Andrade Eric Francelino 
Published: May 2024

Background:
Humic acid (HA) is a bioproduct that can be extracted from different
sources and has anti-inflammatory properties that have been little explored in the treatment and
prevention of Periodontal Disease (PD). Thus, we aimed to investigate the effects of oral administration
of HA on the progression of PD in rats.

Methods:
Twenty-four male Wistar rats were distributed into three experimental groups (Control/
Sham, PD, and PD + HA). HA was administered by gavage (80 mg/kg/day) for 28 days, and
PD was induced 14 days after the beginning of treatment. Bone loss, bone topography, and surface
elemental composition were analyzed. Circulating IL1-beta, TNF-alpha, and IL-10 levels
were evaluated through Enzyme-Linked Immunosorbent Assay (ELISA).

Results:
The animals treated with HA showed lower bone loss (p < 0.05). Calcium and phosphorus
levels on the alveolar bone surface were lower in the PD group (p < 0.05) compared to the control
group, whereas the animals treated with HA exhibited attenuation in this loss (p < 0.05). The
animals treated with HA showed reduced TNF-alpha, IL1-beta, IL-10, and the TNF-alpha/IL-10
ratio compared to those with PD (p < 0.05).

Conclusion:
Treatment with HA attenuated the parameters of alveolar bone loss and modulated
systemic inflammatory parameters in rats with ligature-induced PD.
Bioinformatics Characteristics and Genomic Patterns of the Envelope Glycoproteins of the Crimean-congo Hemorrhagic Fever Viruses
Authors: Polanco Carlos , Uversky Vladimir N. , Huberman Alberto , Pimentel-Hernandez Claudia , Rios Castro Martha , Hernandez-Lemus Enrique , Buhse Thomas , Alarcon Gilberto Vargas , Roldan Gomez Francisco J. , Martinez-Garcia Mireya , Corona Gabriela Calvo-Leroux , Becerra-Luna Brayans , Gutierrez Juarez Cynthia Karen , Diaz Gonzalez Juan Luciano , Martinez-Memije Raul , Flores Ch Pedro L 
Published: May 2024

Background:
Rodents and many wild and domestic animals, including cattle, donkeys,
goats, hares, ostriches, and sheep, spread the Crimean-Congo Hemorrhagic Fever Virus (CCHFV),
acting as hosts for infected ticks primarily of the Hyalomma genus, which serve as vectors and reservoirs
of the virus. CCHF is a severe, potentially lethal, and widespread disease, making it a serious
public health issue. Environmental changes impacting rodent populations affect their global distribution
and, therefore, play a role in the spread of CCHFV.

Objective:
This study aims togain a deeper understanding of the envelope glycoproteins expressed by
the CCHFV.

Methods:
Multiple computational algorithms determined the Intrinsic Disorder Predisposition
(PIDP), Polarity Index, and genomic profiles of each sequence of the glycoproteins.

Results:
When examining the Polarity Index Method Profile, 3.0v profile, and the PIDP profile, the
envelope glycoproteins of the CCHFV showed different patterns. With these patterns, it was possible
to identify structural and morphological similarities.

Conclusion:
With the PIM 3.0v profile, our computer programs were able to identify isolated
CCHFV envelope glycoproteins. We believe that this research provides a deeper understanding of
this virus.
Muscle Transcriptome Provides Insights into the Allergen Profile of Habitat-specific Mature Hilsa shad (Tenualosa ilisha)
Authors: Mou Sadia Noor , Rupa Afsana Akter , Chowdhury Md. Arko Ayon , Rahi Md. Lifat , Baten Abdul , Ali Amin Ahsan , Khan Haseena , Amin Md. Ashraful , Islam Mohammad Riazul 
Published: May 2024

Background:
Hilsa shad (Tenualosa ilisha) is a popular anadromous fish in Bangladesh
known to cause allergies. Despite recognized allergenicity, there is a paucity of research at the
molecular level on hilsa allergen.

Methods:
Muscle transcriptomes of hilsa from freshwater, brackish, and deep sea habitats were
sequenced using Illumina NovaSeq 6000 and assembled. BLASTx analysis of the Allergen Online
database identified potential allergens. The molecular docking study investigated parvalbumin’s
interaction with human IgE.

Results:
An analysis of hilsa muscle transcriptomes revealed 28 known fish allergens, including
parvalbumin, tropomyosin, including parvalbumin, tropomyosin, filamin C, creatine kinase-2,
aldolase A, triosephosphate isomerase B, and Glyceraldehyde-3-phosphate Dehydrogenase
(G3PD). Creatine kinase showed significantly higher abundance (p < 0.05) and habitat variation
(freshwater vs. brackish water). In silico analysis suggested upregulation of Sal s 2 enolase and
Equ c 6 lysozyme in freshwater and brackish water compared to the deep sea. Docking studies
identified a potential B-cell epitope in parvalbumin that interacts with human IgE.

Conclusion:
This study has unveiled 28 potential allergens in hilsa, including habitat-specific variations.
The parvalbumin-IgE interaction has been suggested as a mechanism for allergies. The
findings have illuminated fish allergy in Bangladesh and paved the way for further investigation.
Urinary miRNAs: Technical Updates
Authors: Raveendran Santhi , Al Massih Alia , Al Hashmi Muna , Saeed Asma , Al-Azwani Iman , Mathew Rebecca , Tomei Sara 
Published: May 2024

:
Due to its non-invasive nature and easy accessibility, urine serves as a convenient
biological fluid for research purposes. Furthermore, urine samples are uncomplicated to preserve
and relatively inexpensive.

:
MicroRNAs (miRNAs), small molecules that regulate gene expression post-transcriptionally,
play vital roles in numerous cellular processes, including apoptosis, cell differentiation, development,
and proliferation. Their dysregulated expression in urine has been proposed as a potential
biomarker for various human diseases, including bladder cancer. To draw reliable conclusions
about the roles of urinary miRNAs in human diseases, it is essential to have dependable and
reproducible methods for miRNA extraction and profiling.

:
In this review, we address the technical challenges associated with studying urinary miRNAs and
provide an update on the current technologies used for urinary miRNA isolation, quality control
assessment, and miRNA profiling, highlighting both their advantages and limitations.
A Decade of Advancement in Ruthenium (II)-Catalyzed Direct C-H Activation and Consequent C-C/C-N Bond Formation Using Microwave Heating
Authors: Kausar Nazia 
Published: May 2024

:
Transition-metal catalysed activation of unreactive C-H bonds and subsequent C-C bond formation has emerged as a principal and essential tool in the field of synthetic organic chemistry. On the other hand, the microwave heating technique has been intensively used to carry out organic transformation of almost all kinds and has become a promising non-conventional technique for performing synthetic reactions. Direct C-H activation for C-C bond-forming reactions using ruthe-nium as a catalyst is currently a hot topic and represents a cost-effective synthetic pathway in or-ganic chemistry which is accompanied by the advantages of MW irradiation resulting in shorter reaction time and greener 3 as well as sustainable accomplishments.
Findings From a National Survey of Older US Adults on Patient Willingness to Use Telehealth Services: Cross-Sectional Survey
Authors: Odebunmi Olufeyisayo O , Hughes Tamera D , Waters Austin R , Urick Benjamin Y , Herron Caroline , Wangen Mary , Rohweder Catherine , Ferrari Renée M , Marciniak Macary W , Wheeler Stephanie B , Brenner Alison T , Shah Parth D 
Published: May 2024

Background
Telehealth (telemedicine and telepharmacy) services increase access to patient services and ensure continuity of care. However, few studies have assessed factors that influence patients’ willingness to use telehealth services, and we sought to investigate this.

Objective
This study aims to examine respondents’ (aged between 45 and 75 years) willingness to use telehealth services (telepharmacy and telemedicine) and the correlates of the willingness to use telehealth services.

Methods
We administered a cross-sectional national survey of 1045 noninstitutionalized US adults aged between 45 and 75 years in March and April 2021. Multiple logistic regression analyses were used to identify demographic and health service use correlates of self-reported willingness to use telehealth services.

Results
Overall willingness to use telemedicine was high (674/1045, 64.5%). Adults aged 55 years and older were less willing to use telemedicine (aged between 55 and 64 years: odds ratio [OR] 0.61, 95% CI 0.42-0.86; aged 65 years or older: OR 0.33, 95% CI 0.22-0.49) than those younger than 55 years. Those with a regular provider (OR 1.01, 95% CI 1-1.02) and long travel times (OR 1.75, 95% CI 1.03-2.98) were more willing to use telemedicine compared to those without a regular provider and had shorter travel times, respectively. Willingness to use telemedicine services increased from 64.5% (674/1045) to 83% (867/1045) if the service was low-cost or insurance-covered, was with their existing health care provider, or was easy-to-use. Overall willingness to use telepharmacy was 76.7% (801/1045). Adults aged older than 55 years were less willing to use telepharmacy (aged between 55 and 64 years: OR 0.57, 95% CI 0.38-0.86; aged 65 years or older: OR 0.24, 95% CI 0.15-0.37) than those younger than 55 years. Those who rated pharmacy service quality higher were more willing to use telepharmacy (OR 1.06, 95% CI 1.03-1.09) than those who did not.

Conclusions
Respondents were generally willing to use telehealth (telemedicine and telepharmacy) services, but the likelihood of their being willing to use telehealth decreased as they were older. For those initially unwilling (aged 55 years or older) to use telemedicine services, inexpensive or insurance-covered services were acceptable.
An Approach to the Design and Development of an Accredited Continuing Professional Development e-Learning Module on Virtual Care
Authors: Curran Vernon , Glynn Robert , Whitton Cindy , Hollett Ann 
Published: May 2024

Abstract
Virtual care appointments expanded rapidly during COVID-19 out of necessity and to enable access and continuity of care for many patients. While previous work has explored health care providers’ experiences with telehealth usage on small-scale projects, the broad-level adoption of virtual care during the pandemic has expounded opportunities for a better understanding of how to enhance the integration of telehealth as a regular mode of health care services delivery. Training and education for health care providers on the effective use of virtual care technologies are factors that can help facilitate improved adoption and use. We describe our approach to designing and developing an accredited continuing professional development (CPD) program using e-learning technologies to foster better knowledge and comfort among health care providers with the use of virtual care technologies. First, we discuss our approach to undertaking a systematic needs assessment study using a survey questionnaire of providers, key informant interviews, and a patient focus group. Next, we describe our steps in consulting with key stakeholder groups in the health system and arranging committees to inform the design of the program and address accreditation requirements. The instructional design features and aspects of the e-learning module are then described in depth, and our plan for evaluating the program is shared as well. As a CPD modality, e-learning offers the opportunity to enhance access to timely continuing professional education for health care providers who may be geographically dispersed across rural and remote communities.
Sociodigital Determinants of eHealth Literacy and Related Impact on Health Outcomes and eHealth Use in Korean Older Adults: Community-Based Cross-Sectional Survey
Authors: Kyaw Myat Yadana , Aung Myo Nyein , Koyanagi Yuka , Moolphate Saiyud , Aung Thin Nyein Nyein , Ma Hok Ka Carol , Lee Hocheol , Nam Hae-Kweun , Nam Eun Woo , Yuasa Motoyuki 
Published: May 2024

Abstract

Background
eHealth literacy is an essential skill for pursuing electronic health information, particularly for older people whose health needs increase with age. South Korea is now at the intersection of a rapidly digitalizing society and an increasingly aged population. eHealth literacy enables older people to maximize the effective use of emerging digital technology for their health and quality of life. Understanding the eHealth literacy of Korean older adults is critical to eliminating the gray digital divide and inequity in health information access.

Objective
This study aims to investigate factors influencing eHealth literacy in older Korean adults and its impact on health outcomes and eHealth use.

Methods
This was a cross-sectional survey. Community-dwelling older adults 65 years and older in 2 urban cities in South Korea were included. eHealth literacy was measured by the eHealth Literacy Scale. Ordinal logistic regression was used to analyze factors associated with eHealth literacy and multivariate ANOVA for the impact of eHealth literacy on health outcomes and eHealth use.

Results
In total, 434 participants were analyzed. A total of 22.3% (97/434) of participants had high eHealth literacy skills. Increasing age, higher monthly income, and time spent on the internet were significantly associated with eHealth literacy (P<.001), and social media users were 3.97 times (adjusted odds ratio 3.97, 95% CI 1.02‐15.43; P=.04) more likely to have higher skill. Higher eHealth literacy was associated with better self-perceived health and frequent use of digital technologies for accessing health and care services (P<.001).

Conclusions
Disparity in socioeconomic status and engagement on the internet and social media can result in different levels of eHealth literacy skills, which can have consequential impacts on health outcomes and eHealth use. Tailored eHealth interventions, grounded on the social and digital determinants of eHealth literacy, could facilitate eHealth information access among older adults and foster a digitally inclusive healthy aging community.
The Tumor Immune Microenvironment in Breast Cancer Progression
Authors: Otterlei Fjørtoft Marit , Huse Kanutte , Rye Inga Hansine 
Published: May 2024

Background: The tumor microenvironment significantly influences breast cancer development, progression, and metastasis. Various immune cell populations, including T cells, B cells, NK cells, and myeloid cells exhibit diverse functions in different breast cancer subtypes, contributing to both anti-tumor and pro-tumor activities.
Purpose: This review provides an overview of the predominant immune cell populations in breast cancer subtypes, elucidating their suppressive and prognostic effects. We aim to outline the role of the immune microenvironment from normal breast tissue to invasive cancer and distant metastasis.
Methods: A comprehensive literature review was conducted to analyze the involvement of immune cells throughout breast cancer progression.
Results: In breast cancer, tumors exhibit increased immune cell infiltration compared to normal tissue. Variations exist across subtypes, with higher levels observed in triple-negative and HER2+ tumors are linked to better survival. In contrast, ER+ tumors display lower immune infiltration, associated with poorer outcomes. Furthermore, metastatic sites commonly exhibit a more immunosuppressive microenvironment.
Conclusion: Understanding the complex interaction between tumor and immune cells during breast cancer progression is essential for future research and the development of immune-based strategies. This comprehensive understanding may pave the way for more effective treatment approaches and improved patients outcomes.
Hva gjør pedagogene i barnehagen? Barnehagelærernes arbeidsdeling i møte med skjerpet pedagognorm
Authors: Homme Anne , Eide Helene Marie Kjærgård 
Published: May 2024

Skjerpet pedagognorm i barnehagene kan ses som uttrykk for at pedagogisk kompetanse og kvalitet sesi sammenheng. Denne artikkelen undersøker hvordan ansvar og oppgaver fordeles mellom pedagoger ibarnehagen og hvilken betydning ulike måter å organisere pedagogressursen kan få for barnehagelærerprofesjonensjurisdiksjon på barnehagefeltet. Artikkelen bygger på data fra en komparativ caseundersøkelsei åtte barnehager i 2017 og 2018 som hadde femti prosent andel barnehagelærere. Vi har intervjuetstyrere, pedagoger, fagarbeidere/assistenter og eierrepresentanter. Analysen bygger på teori om profesjonssystemer(Abbott, 1988) og viser hvordan arbeidsdeling skjer ut fra subjektive problemdefinisjoner avbarnehagelærernes og fagarbeidernes/assistentenes oppgaver. Barnehagelærerne i de ulike barnehagene tildeles forskjellige oppgaver og ansvarsområder. Noen får et mer spesialisert ansvar, mens andre utformer barnehagelæreroppgaver som en støttefunksjon til pedagogisk lederrollen. Forhandlinger om arbeidsoppgaver kan muliggjøre og utfordre barnehagelærernes profesjonalisering. Analysen indikerer at det fortsatt er en vei å gå i arbeidet med å fastsette profesjonens ambisjon med den skjerpede pedagognormen. Arbeidsdelingsprosessene er i stadig endring og bør følges videre opp med forskning som kan tilføre ny kunnskap om hvordan skjerpet pedagognorm kan styrke kompetanse, profesjonalisering og det pedagogiske arbeidet i barnehagen.
ENGLISH ABSTRACT
What Do the Teachers Do? The Division of Labour Between Early Childhood Teachers in Kindergartens With Increased Teacher-to-Child Ratio
Norwegian national regulations that increase the percentage of early childhood teachers among staff in kindergartens indicate that pedagogical competence and quality are related. However, we need more insight into how quality, teacher professional competence and staffing are linked in the kindergartens. The article is based on data from a comparative case study in eight kindergartens in 2017 and 2018 which all had a proportion of fifty per cent teachers among their staff. The data consists of interviews with kindergarten heads, teachers, skilled workers, assistants, and owners. The analysis is based on a theoretical approach on the system of professions (Abbott, 1988), and shows how the division of labor based on subjective problem definitions vary between the kindergartens. Negotiations on work tasks at the local level both enable and challenge the professionalization of teachers. Thus, we find that the government’s ambitions to strengthen competence and thereby quality in the kindergarten sector can be implemented in various ways. An increase of kindergarten teachers among staff does not necessarily strengthen specialization of professional practice. Further, the work of determining the profession’s ambition with the teacher staffing regulation is yet still to be developed and defined.