bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double‐Salts Super Concentrated Carbonate Electrolyte Boosting Electrochemical Performance of Ni‐Rich LiNi0.90Co0.05Mn0.05O2 Lithium Metal Batteries
Authors: Yang Qiang , Liu Qi , Tan Guoqiang , Li Li , Chen Renjie , Wu Feng 
Published: May 2024

AbstractCurrent lithium‐ion batteries cannot meet the requirement of higher energy density with further large‐scale application of electrical vehicles. Lithium metal batteries combined with Ni‐rich layered oxides cathode are expected as the one of promising solutions, while the poor electrode and electrolyte interface impedes the commercial development of lithium metal batteries. A new double‐salts super concentrated (DSSC) carbonate electrolyte is proposed to improve the electrochemical performance of LiNi0.90Co0.05Mn0.05O2 (NCM9055)||Li metal battery which exhibits stable cycling performance with the capacity retention of 93.04% and reversible capacity of 173.8 mAh g−1 after 100 cycles at 1 C, while cells with conventional 1 m diluted electrolyte remains only 60.55% and capacity of 114.2 mAh g−1. The double salts synergistic effect in super concentrated electrolyte promotes the formation for more balanced stable cathode electrolyte interface (CEI) inorganic compounds of CFx, LiNOx, SOF2, Li2SO4, and less LiF by X‐ray photoelectron spectroscopy (XPS) test, and the uniform 2–3 nm rock‐salt phase protection layer on the cathode surface by transmission electron microscope (TEM) characterization, improving the cycling performance of the Ni‐rich NCM9055 layered oxide cathode. The DSSC electrolyte also can relief the Li dendrite growth on Li metal anode, as well as exhibit better flame retardance, promoting the application of more safety Ni‐rich NCM9055||Li metal batteries.
Manipulating Chiroptical Activities in 0D Chiral Hybrid Manganese Bromides by Solvent Molecular Engineering
Authors: Li Chen , Wei Yi , Li Yawen , Luo Zhishan , Liu Yulian , He Meiying , Zhang Yan , He Xin , Chang Xiaoyong , Quan Zewei 
Published: May 2024

Abstract0D hybrid metal halides (0D HMHs) with fully isolated inorganic units provide an ideal platform for studying the correlations between chiroptical activities and crystal structures at atomic levels. Here, through the incorporation of different solvent molecules, a series of 0D chiral manganese bromides (RR/SS‐C20H28N2)3MnBr8·2X (X = C2H5OH, CH3OH, or H2O) are synthesized to elucidate their chiroptical properties. They show negligible circular dichroism signals of Mn absorptions due to C2v‐symmetric [MnBr4]2− tetrahedra. However, they display distinct circularly polarized luminescence (CPL) signals with continuously increased luminescence asymmetry factors (glum) from 10−4 (X = C2H5OH) to 10−3 (X = H2O). The increased glum value is structurally revealed to originate from the enhancement of [MnBr4]2‐ tetrahedral bond‐angle distortions, due to the presence of different solvent molecules. Furthermore, (RR/SS‐C20H28N2)MnBr4·H2O enantiomers with larger bond‐angle distortions of [MnBr4]2− tetrahedra are synthesized based on hydrobromic acid‐induced structural transformation of (RR/SS‐C20H28N2)3MnBr8·2H2O enantiomers. Therefore, such (RR/SS‐C20H28N2)MnBr4·H2O enantiomers exhibit enhanced CPL signals with |glum| up to 1.23 × 10−2. This work provides unique insight into enhancing chiroptical activities in 0D HMH systems.
General Synthesis of Metal Indium Sulfide Atomic Layers for Photocatalysis
Authors: Di Jun , Chen Chao , Zhu Chao , Cao Xun , Xiong Jun , Long Ran , Li Shuzhou , Jiang Wei , Liu Zheng 
Published: May 2024

AbstractThe metal indium sulfides have attracted extensive research interest in photocatalysis due to regulable atomic configuration and excellent optoelectronic properties. However, the synthesis of metal indium sulfide atomic layers is still challenging since intrinsic non‐van‐der‐Waals layered structures of some components. Here, a surfactant self‐assembly growth mechanism is proposed to controllably synthesize metal indium sulfide atomic layers. Eleven types of atomic layers with tunable compositions, thickness, and defect concentrations are successfully achieved namely In2S3, MgIn2S4, CaIn2S4, MnIn2S4, FeIn2S4, ZnIn2S4, Zn2In2S5, Zn4In16S33, CuInS2, CuIn5S8, and CdIn2S4. The typical CaIn2S4 shows a defect‐dependence activity for CO2 photoreduction. The designed S vacancies in CaIn2S4 can serve as catalytic centers to activate CO2 molecules via localized electrons for π‐back‐donation. The engineered S vacancies tune the non‐covalent interaction with CO2 and intermediates, manages to tune the free energy, and lower the reaction energy barrier. As a result, the defect‐rich CaIn2S4 displays 2.82× improved reduction rate than defect‐poor CaIn2S4. Meantime, other components also display promising photocatalytic performance, such as Zn2In2S5 with a H2O2 photosynthesis rate of 292 µmol g−1 h−1 and CuInS2 with N2−NH4+ conversion rate of 54 µmol g−1 h−1. This work paves the way for the multidisciplinary exploration of metal indium sulfide atomic layers with unique photocatalysis properties.
Expanding the modelling capabilities of systemic interactions utilizing applied category theory
Authors: Wilkinson Neal , Calvo‐Amodio Javier 
Published: May 2024

AbstractCurrent systems analysis approaches often lack the necessary clarity to capture details relating to the interactions of systems, defining arbitrary system boundaries, and expanding boundaries to capture interactions of interest. This paper proposes a new approach for identifying and defining system boundaries based on system‐level properties that can be defined in any system. The research proposes a unification of methodological understandings between systems analysis and applied category theory to bring further mathematical rigor to abstract system boundaries and interactions. This unification is demonstrated by the expansion of systemic interactions between an individual and an organization that employs them, periodically integrating applied category theory concepts to expand the scope of modelled information. We conclude with a call to action to further define the applications of applied category theory to systems analysis and to apply the rigorous practices that exist in the field to further the advancement of methods for modelling the exploration of systemic interactions.
A systems thinking approach to reimagining innovation models: The example of clean hydrogen
Authors: McAvoy Sue , Meath Cristyn , Toth‐Peter Agnes , Jagdish Ninad , Karlovsek Jurij 
Published: May 2024

AbstractAs global temperatures, ocean heat and greenhouse gases reach record levels, transitioning to renewable energy systems offers hope for climate stabilisation. Globally, renewable capacity rose by 50% from 2022 to 2023. Clean hydrogen is attracting strong investment, yet its development is challenging as it requires supply chain‐wide innovation. Sustainably transitioning to hydrogen will require thinking and acting systemically, as opposed to current business‐as‐usual innovation. Whilst hinting at non‐linear relations and feedback loops, prevailing representations of innovation theories remain largely devoid of the feedback structures evident in transitioning socio‐technical systems. In this paper, generational innovation theories are recast as causal loop diagrams (CLDs), and the Success to the Successful archetype is modified to reflect the multi‐level perspective on transition theory. The outcome is twofold: to promote thinking systemically when innovating and diagnosing issues, and to show how CLDs can help elucidate the factors and interactions influencing hydrogen's trajectory.
Prognostic role of the updated Kiel classification in canine high‐grade T‐cell lymphomas
Authors: Jankowska Urszula , Jagielski Dariusz , Czopowicz Michał , Sapierzyński Rafał 
Published: May 2024

AbstractBackgroundThe aim of this study was to determine and describe the prognostic role of the morphological subtype determined according to the updated Kiel classification in dogs with high‐grade T‐cell lymphomas (HGTCLs) depending on the treatment applied.ObjectivesThe HGTCLs were classified into three subtypes according to the updated Kiel classification: pleomorphic mixed (PM), lymphoblastic lymphoma/acute lymphoblastic leukaemia and plasmacytoid (P). The treatment was divided into a palliative therapy (PlT) group and a chemotherapy (ChT) group.MethodsThe study was conducted between 2009 and 2017, and it enrolled 58 dogs in which cytomorphological and immunocytochemistry diagnoses were HGTCL.ResultsOverall survival (OS) was significantly longer in the ChT group (median OS—4 months, interquartile range [IQR] from 2 to 8 months) than in the PlT group (median OS—6 weeks, IQR from 1 week to 3 months).In the PlT group, PM subtype and glucocorticosteroids (GCSs) treatment proved significantly and independently linked to longer OS and approximately three‐fold lower risk of death during the study period (adjusted hazard ratio [HRadj] = 0.26, confidence interval [CI] 95%: 0.08–0.81; p = 0.020 and HRadj = 0.30, CI 95%: 0.11–0.77; p = 0.013, respectively), although due to small group size, precision of estimations was poor (wide CI 95%).In the ChT group, >7 days elapsing between diagnosis and the beginning of chemotherapy and GCS treatment prior to chemotherapy were significantly associated with lower chance of complete remission (CR; p = 0.034 for both); GCS treatment prior to chemotherapy was significantly associated with shorter OS (p = 0.016); chemotherapy based on the modified CHOP protocol was significantly associated with higher chance of CR (p = 0.034) and longer OS (p = 0.039); and CR was significantly linked to longer OS (p = 0.001).Clinical significanceThe morphological subtype of HGTCL has some prognostic value in dogs treated palliatively (with PM subtype associated with longer OS than P subtype); however, this effect is no longer visible when a dog is treated with chemotherapy.
Cholelithiasis in a goat associated with chronic fascioliosis in Bangladesh: A case report and review of literatures
Authors: Ali Md. Haydar , Labony Sharmin Shahid , Hossain Md. Shahadat , Alam Md. Mahmudul , Khan Md. Abu Hadi Noor Ali , Alim Md. Abdul , Anisuzzaman  
Published: May 2024

AbstractThe objective of the present study was to describe a very rare case of gallstone (cholelithiasis) in a goat associated with chronic fasciolosis. During a routine slaughterhouse‐based survey, a two‐and‐half‐year‐old female Black Bengal Goat was found to be affected with severe chronic fascioliosis characterized by the massive damage in the liver. Through systemic dissection of liver, we isolated 94 adult Fasciola spp., and by PCR, we confirmed the fluke as Fasciola gigantica. The gallbladder of the goat was oedematous. On opening the gallbladder, we recovered 255 stones of variable sizes. Stones were whitish in colour and friable, and some of the fragile stones were attached to the wall of the gallbladder. To the authors’ knowledge, this is the first report of the cholelithiasis in a goat associated with F. gigantica.
P62 promotes FSH-induced antral follicle formation by directing degradation of ubiquitinated WT1
Authors: Zhao Ting , He Meina , Zhu Zijian , Zhang Tuo , Zheng Wenying , Qin Shaogang , Gao Meng , Wang Wenji , Chen Ziqi , Han Jun , Liu Longping , Zhou Bo , Wang Haibin , Zhang Hua , Xia Guoliang , Wang Jianbin , Wang Fengchao , Wang Chao 
Published: May 2024

AbstractIn females, the pathophysiological mechanism of poor ovarian response (POR) is not fully understood. Considering the expression level of p62 was significantly reduced in the granulosa cells (GCs) of POR patients, this study focused on identifying the role of the selective autophagy receptor p62 in conducting the effect of follicle-stimulating hormone (FSH) on antral follicles (AFs) formation in female mice. The results showed that p62 in GCs was FSH responsive and that its level increased to a peak and then decreased time-dependently either in ovaries or in GCs after gonadotropin induction in vivo. GC-specific deletion of p62 resulted in subfertility, a significantly reduced number of AFs and irregular estrous cycles, which were same as pathophysiological symptom of POR. By conducting mass spectrum analysis, we found the ubiquitination of proteins was decreased, and autophagic flux was blocked in GCs. Specifically, the level of nonubiquitinated Wilms tumor 1 homolog (WT1), a transcription factor and negative controller of GC differentiation, increased steadily. Co-IP results showed that p62 deletion increased the level of ubiquitin-specific peptidase 5 (USP5), which blocked the ubiquitination of WT1. Furthermore, a joint analysis of RNA-seq and the spatial transcriptome sequencing data showed the expression of steroid metabolic genes and FSH receptors pivotal for GCs differentiation decreased unanimously. Accordingly, the accumulation of WT1 in GCs deficient of p62 decreased steroid hormone levels and reduced FSH responsiveness, while the availability of p62 in GCs simultaneously ensured the degradation of WT1 through the ubiquitin‒proteasome system and autophagolysosomal system. Therefore, p62 in GCs participates in GC differentiation and AF formation in FSH induction by dynamically controlling the degradation of WT1. The findings of the study contributes to further study the pathology of POR.
Cystatin C loaded in brain-derived extracellular vesicles rescues synapses after ischemic insult in vitro and in vivo
Authors: Gui Yuqi , Kim Yohan , Brenna Santra , Wilmes Maximilian , Zaghen Giorgio , Goulbourne Chris N. , Kuchenbecker-Pöls Lennart , Siebels Bente , Voß Hannah , Gocke Antonia , Schlüter Hartmut , Schweizer Michaela , Altmeppen Hermann C. , Magnus Tim , Levy Efrat , Puig Berta 
Published: May 2024

AbstractSynaptic loss is an early event in the penumbra area after an ischemic stroke. Promoting synaptic preservation in this area would likely improve functional neurological recovery. We aimed to detect proteins involved in endogenous protection mechanisms of synapses in the penumbra after stroke and to analyse potential beneficial effects of these candidates for a prospective stroke treatment. For this, we performed Liquid Chromatography coupled to Mass Spectrometry (LC–MS)-based proteomics of synaptosomes isolated from the ipsilateral hemispheres of mice subjected to experimental stroke at different time points (24 h, 4 and 7 days) and compared them to sham-operated mice. Proteomic analyses indicated that, among the differentially expressed proteins between the two groups, cystatin C (CysC) was significantly increased at 24 h and 4 days following stroke, before returning to steady-state levels at 7 days, thus indicating a potential transient and intrinsic rescue mechanism attempt of neurons. When CysC was applied to primary neuronal cultures subjected to an in vitro model of ischemic damage, this treatment significantly improved the preservation of synaptic structures. Notably, similar effects were observed when CysC was loaded into brain-derived extracellular vesicles (BDEVs). Finally, when CysC contained in BDEVs was administered intracerebroventricularly to stroked mice, it significantly increased the expression of synaptic markers such as SNAP25, Homer-1, and NCAM in the penumbra area compared to the group supplied with empty BDEVs. Thus, we show that CysC-loaded BDEVs promote synaptic protection after ischemic damage in vitro and in vivo, opening the possibility of a therapeutic use in stroke patients.
Mechanistic screening of reproductive toxicity in a novel 3D testicular co-culture model shows significant impairments following exposure to low-dibutyl phthalate concentrations
Authors: Almamoun Radwa , Pierozan Paula , Karlsson Oskar 
Published: May 2024

AbstractTo improve the mechanistic screening of reproductive toxicants in chemical-risk assessment and drug development, we have developed a three-dimensional (3D) heterogenous testicular co-culture model from neonatal mice. Di-n-butyl phthalate (DBP), an environmental contaminant that can affect reproductive health negatively, was used as a model compound to illustrate the utility of the in vitro model. The cells were treated with DBP (1 nM to 100 µM) for 7 days. Automated high-content imaging confirmed the presence of cell-specific markers of Leydig cells (CYP11A1 +), Sertoli cells (SOX9 +), and germ cells (DAZL +). Steroidogenic activity of Leydig cells was demonstrated by analyzing testosterone levels in the culture medium. DBP induced a concentration-dependent reduction in testosterone levels and decreased the number of Leydig cells compared to vehicle control. The levels of steroidogenic regulator StAR and the steroidogenic enzyme CYP11A1 were decreased already at the lowest DBP concentration (1 nM), demonstrating upstream effects in the testosterone biosynthesis pathway. Furthermore, exposure to 10 nM DBP decreased the levels of the germ cell-specific RNA binding protein DAZL, central for the spermatogenesis. The 3D model also captured the development of the Sertoli cell junction proteins, N-cadherin and Zonula occludens protein 1 (ZO-1), critical for the blood–testis barrier. However, DBP exposure did not significantly alter the cadherin and ZO-1 levels. Altogether, this 3D in vitro system models testicular cellular signaling and function, making it a powerful tool for mechanistic screening of developmental testicular toxicity. This can open a new avenue for high throughput screening of chemically-induced reproductive toxicity during sensitive developmental phases.
Escaping Fatou components with disjoint hyperbolic limit sets
Authors: Beltrami Veronica , Benini Anna Miriam , Saracco Alberto 
Published: May 2024

AbstractWe construct automorphisms of $${{\mathbb {C}}}^2$$

C

2

of constant Jacobian with a cycle of escaping Fatou components, on which there are exactly two limit functions, both of rank 1. On each such Fatou component, the limit sets for these limit functions are two disjoint hyperbolic subsets of the line at infinity. In the literature there are currently very few examples of automorphisms of $${{\mathbb {C}}}^2$$

C

2

with rank one limit sets on the boundary of Fatou components. To our knowledge, this is the first example in which such limit sets are hyperbolic, and moreover different limit sets of rank 1 coexist.
Three-dimensional virtual model for robot-assisted partial nephrectomy: a propensity-score matching analysis with a contemporary control group
Authors: Grosso Antonio Andrea , Di Maida Fabrizio , Lambertini Luca , Cadenar Anna , Coco Simone , Ciaralli Elena , Salamone Vincenzo , Vittori Gianni , Tuccio Agostino , Mari Andrea , Ludovico Giuseppe Mario , Minervini Andrea 
Published: May 2024

Abstract
Purpose
To compare two cohorts of patients submitted to robot-assisted partial nephrectomy (RAPN) with vs without the use of three-dimensional virtual models (3DVMs).

Methods
We screened a prospective consecutive cohort of 152 patients submitted to RAPN with 3DVM and 1264 patients submitted to RAPN without 3DVM between 2019 and 2022. Propensity score matching analysis (PSMA) was applied. Primary endpoint was to evaluate whereas RAPNs with 3DVM were superior in terms of functional outcomes at 12-month. Secondary endopoints were to compare perioperative and oncological outcomes. Multivariable logistic regression analyses (MVA) tested the associations of clinically significant eGFR drop and 3DVMs. Subgroups analysis was performed for PAUDA-risk categories.

Results
100 patients for each group were analyzed after PSMA. RAPN with 3DVM presented a higher rate of selective/no clamping procedure (32% vs 16%, p = 0.03) and a higher enucleation rate (40% vs 29%, p = 0.04). As concern to primary endopoint, 12-month functional preservation performed better within 3DVM group in terms of creatinine serum level (median 1.2 [IQR 1.1–1.4] vs 1.6 [IQR 1.1–1.8], p = 0.03) and eGFR (median 64.6 [IQR 56.2–74.1] vs 52.3 [IQR 49.2–74.1], p = 0.03). However, this result was confirmed only in the PADUA ≥ 10 renal masses. Regarding secondary endpoints, no significative difference emerged between the two cohorts. MVA confirmed 3DVM as a protective factor for clinically significant eGFR drop only in high-risk (PADUA ≥ 10) masses.

Conclusions
RAPN performed with the use of 3DVM assistance resulted in lower incidence of global ischemia and higher rate of enucleations. The positive impact of such technology was found at 12-month only in high-risk renal masses.
Late Triassic to Early Jurassic carbon isotope chemostratigraphy and organo-facies evolution in a distal to proximal transect of the North German Basin
Authors: Ruebsam Wolfgang , Franz Matthias , Ansorge Jörg , Obst Karsten , Schwark Lorenz 
Published: May 2024

AbstractThroughout the Latest Triassic and the Early Jurassic, major changes in paleogeography, climate and eustatic sea-level impacted on the development of shelf depositional environments. Secular trends in environmental conditions were punctuated by transient perturbations that occurred in relation to large-scale volcanic events, such as the emplacement of the Central Atlantic Magmatic Province at the Triassic/Jurassic boundary and the Karoo–Ferrar Large Igneous Province in the early Toarcian. We here present bulk organic (HAWK programmed pyrolysis) and organic carbon isotope (δ13Corg) data for three drill cores recovering Latest Triassic and Early Jurassic strata (Rhaetian to Toarcian). Study sites are located in the northeastern part of the Central European Epicontinental Sea and were positioned along a distal–proximal transect of the North German Basin. This allows discussing the differential response of depositional settings and organo-facies toward secular and transient environmental change. Biostratigraphically anchored trends in δ13Corg values allow the precise correlation along the transect, as well as with distant sites. At all North German locations, diagnostic secular trends in δ13Corg are punctuated by transient negative carbon isotope excursions, reflecting perturbations of the global carbon cycle at the Triassic/Jurassic boundary and in the early Toarcian. Stratigraphic gaps occurred during sea-level lowstands and are most pronounced at shallow proximal sites. Programmed pyrolysis data indicate spatiotemporal organo-facies trends that on a temporal scale occurred in response to sea-level and climate trends, while spatial patterns were governed by basin morphology and paleobathymetry. Substantial marine organic matter accumulations occurred at high sea level during the Toarcian only, and were most continuous at distal sites.
Graphical Abstract