bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term survival in a pediatric patient with supratentorial primitive neuro‐ectodermal tumor and extraneural metastasis at diagnosis
Authors: Rubens Jeffrey , Gosiengfiao Yasmin , Tomita Tadanori , Jacobsohn David A. , Fangusaro Jason 
Published: February 2011

AbstractExtraneural metastases of central nervous system (CNS) tumors are rare occurrences most commonly observed in medulloblastomas. Survival outcomes are generally dismal. Supratentorial primitive neuroectodermal tumors (stPNET) are rare childhood tumors with few documented cases of extraneural metastases. We present a rare occurrence of a 23‐month‐old patient with long‐term survival after diagnosis of stPNET with metastases to the lungs. This patient was treated with surgical resection, induction chemotherapy, tandem autologous hematopoietic cell rescues, and focal radiotherapy. We report long‐term survival for a patient with a stPNET and extraneural metastases at diagnosis following an intensive approach to treatment. Pediatr Blood Cancer 2011; 57: 341–344. © 2011 Wiley‐Liss, Inc.
Antiphospholid antibody syndrome and Hb E/Beta thalassemia disease post‐allogeneic stem cell transplantation
Authors: Sirachainan Nongnuch , Pakakasama Samart , Hongeng Suradej , Chuansumrit Ampaiwan , Tuntiyatorn Lojana , Vilaiyuk Soamarat 
Published: February 2011

AbstractWe report a 10‐year‐old male with Hb E/Beta thalassemia disease who developed chronic graft‐versus‐host disease (cGVHD) of antiphospholipid antibody syndrome after successful allogeneic stem cell transplantation (SCT). He exhibited a recurrent ischemic stroke on day 368 post‐SCT while on cyclosporine A, azathioprine, and prednisolone. The immunosuppressive agents were switched to pulse methylprednisolone, tacolimus, mycophenolate mofetil, and enoxaparin, but the patient was more confused. An additional plasma exchange which was aimed at the immediate removal of autoantibody was performed with a good response. The symptoms rapidly disappeared except for the complex partial seizure which persisted until seven years post‐SCT. Pediatr Blood Cancer 2011;57:153–156. © 2011 Wiley‐Liss, Inc.
Systemic Mastocytosis in a Child With t(8;21) Acute Myeloid Leukemia
Authors: Mahadeo Kris M. , Wolgast Lucia , McMahon Christine , Cole Peter D. 
Published: February 2011

AbstractMastocytosis is primarily limited to the cutaneous variant in pediatric patients. Systemic mastocytosis (SM) has been associated with t(8;21) acute myeloid leukemia (AML) in adults. We provide the first report of a child with t(8;21) AML, diagnosed with asymptomatic SM following four cycles of chemotherapy. Unlike most adults with SM/AML, she was not found to have a c‐KIT (D816V) mutation. SM persisted in the bone marrow after completion of chemotherapy, and her AML relapsed 9 months off‐treatment. Although she achieved a second remission, mastocytosis persists in the marrow. Pediatric patients with t(8;21) AML/SM may represent a high‐risk group despite favorable cytogenetics. Pediatr Blood Cancer 2011; 57: 684–687. © 2011 Wiley‐Liss, Inc.
Electromechanical characteristics of unidirectional glass fiber epoxy composites
Authors: Hwang Hui Yun 
Published: February 2011

AbstractBecause crack detection for laminated composites in‐service is an effective method for improving structural reliability, various nondestructive methods have been studied to detect cracks in laminated composites. A recent study on the damage monitoring of composite materials using the piezoelectric method, which uses the piezoelectric characteristics of polymeric materials for the matrix of composite materials, concluded that the piezoelectric method can be a useful, nondestructive method for the damage monitoring of glass fiber epoxy composites. The dielectric and piezoelectric properties of composites are the basic properties used for the analysis of electromechanical coupling systems, along with the mechanical properties. In this research, therefore, the electromechanical characteristics of unidirectional glass fiber epoxy composites as well as their electric and mechanical characteristics were investigated. The dielectric, piezoelectric, and mechanical properties of unidirectional glass fiber epoxy composites were measured experimentally with respect to the fiber orientation, and the relationship between the piezoelectric and mechanical characteristics of unidirectional glass fiber epoxy composites was analyzed. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
Genome‐wide identification of the subcellular localization of the Escherichia coli B proteome using experimental and computational methods
Authors: Han Mee‐Jung , Yun Hongseok , Lee Jeong Wook , Lee Yu Hyun , Lee Sang Yup , Yoo Jong‐Shin , Kim Jin Young , Kim Jihyun F. , Hur Cheol‐Goo 
Published: February 2011

AbstractEscherichia coli K‐12 and B strains have most widely been employed for scientific studies as well as industrial applications. Recently, the complete genome sequences of two representative descendants of E. coli B strains, REL606 and BL21(DE3), have been determined. Here, we report the subproteome reference maps of E. coli B REL606 by analyzing cytoplasmic, periplasmic, inner and outer membrane, and extracellular proteomes based on the genome information using experimental and computational approaches. Among the total of 3487 spots, 651 proteins including 410 non‐redundant proteins were identified and characterized by 2‐DE and LC‐MS/MS; they include 440 cytoplasmic, 45 periplasmic, 50 inner membrane, 61 outer membrane, and 55 extracellular proteins. In addition, subcellular localizations of all 4205 ORFs of E. coli B were predicted by combined computational prediction methods. The subcellular localizations of 1812 (43.09%) proteins of currently unknown function were newly assigned. The results of computational prediction were also compared with the experimental results, showing that overall precision and recall were 92.16 and 92.16%, respectively. This work represents the most comprehensive analyses of the subproteomes of E. coli B, and will be useful as a reference for proteome profiling studies under various conditions. The complete proteome data are available online (http://ecolib.kaist.ac.kr).
Inhibition of Ataxia Telangiectasia- and Rad3 -Related Function Abrogates the In Vitro and In Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133+ Tumor-Initiating Cell Fraction
Authors: Gallmeier Eike , Hermann Patrick C. , Mueller Maria-Theresa , Machado Juan G. , Ziesch Andreas , De Toni Enrico N. , Palagyi Andreas , Eisen Christian , Ellwart Joachim W. , Rivera Jose , Rubio-Viqueira Belen , Hidalgo Manuel , Bunz Fred , Göke Burkhard , Heeschen Christopher 
Published: February 2011

AbstractThe identification of novel approaches to specifically target the DNA-damage checkpoint response in chemotherapy-resistant cancer stem cells (CSC) of solid tumors has recently attracted great interest. We show here in colon cancer cell lines and primary colon cancer cells that inhibition of checkpoint-modulating phosphoinositide 3-kinase-related (PIK) kinases preferentially depletes the chemoresistant and exclusively tumorigenic CD133+ cell fraction. We observed a time- and dose-dependent disproportionally pronounced loss of CD133+ cells and the consecutive lack of in vitro and in vivo tumorigenicity of the remaining cells. Depletion of CD133+ cells was initiated through apoptosis of cycling CD133+ cells and further substantiated through subsequent recruitment of quiescent CD133+ cells into the cell cycle followed by their elimination. Models using specific PIK kinase inhibitors, somatic cell gene targeting, and RNA interference demonstrated that the observed detrimental effects of caffeine on CSC were attributable specifically to the inhibition of the PIK kinase ataxia telangiectasia- and Rad3-related (ATR). Mechanistically, phosphorylation of CHK1 checkpoint homolog (S. pombe; CHK1) was significantly enhanced in CD133+ as compared with CD133− cells on treatment with DNA interstrand-crosslinking (ICL) agents, indicating a preferential activation of the ATR/CHK1-dependent DNA-damage response in tumorigenic CD133+ cells. Consistently, the chemoresistance of CD133+ cells toward DNA ICL agents was overcome through inhibition of ATR/CHK1-signaling. In conclusion, our study illustrates a novel target to eliminate the tumorigenic CD133+ cell population in colon cancer and provides another rationale for the development of specific ATR-inhibitors.
Specific Glycosaminoglycans Modulate Neural Specification of Mouse Embryonic Stem Cells
Authors: Pickford Claire E. , Holley Rebecca J. , Rushton Graham , Stavridis Marios P. , Ward Christopher M. , Merry Catherine L.R. 
Published: February 2011

Abstract
Mouse embryonic stem (mES) cells express a low sulfated form of heparan sulfate (HS). HS chains displayed by ES cells and their progeny become more complex and more sulfated during progression from pluripotency to neuroectodermal precursors. Sulfated epitopes are important for recognition and binding of a variety of ligands including members of the fibroblast growth factor (FGF) family. We demonstrated previously that mES cells lacking HS cannot undergo neural specification but this activity can be recovered by adding soluble heparin, a highly sulfated glycosaminoglycan (GAG). Therefore, we hypothesized that soluble GAGs might be used to support neural differentiation of HS competent cells and that the mechanisms underlying this activity might provide useful information about the signaling pathways critical for loss of pluripotency and early lineage commitment. In this study, we demonstrate that specific HS/heparin polysaccharides support formation of Sox1+ neural progenitor cells from wild-type ES cells. This effect is dependent on sulfation pattern, concentration, and length of saccharide. Using a selective inhibitor of FGF signal transduction, we show that heparin modulates signaling events regulating exit from pluripotency and commitment to primitive ectoderm and subsequently neuroectoderm. Interestingly, we were also able to demonstrate that multiple receptor tyrosine kinases were influenced by HS in this system. This suggests roles for additional factors, possibly in cell proliferation or protection from apoptosis, during the process of neural specification. Therefore, we conclude that soluble GAGs or synthetic mimics could be considered as suitable low-cost factors for addition to ES cell differentiation regimes.
Concise Review: Induced Pluripotent Stem Cells and Lineage Reprogramming: Prospects for Bone Regeneration
Authors: Illich Damir J. , Demir Necati , Stojković Miodrag , Scheer Martin , Rothamel Daniel , Neugebauer Jörg , Hescheler Jürgen , Zöller Joachim E. 
Published: February 2011

AbstractBone tissue for transplantation therapies is in high demand in clinics. Osteodegenerative diseases, in particular, osteoporosis and osteoarthritis, represent serious public health issues affecting a respectable proportion of the elderly population. Furthermore, congenital indispositions from the spectrum of craniofacial malformations such as cleft palates and systemic disorders including osteogenesis imperfecta are further increasing the need for bone tissue. Additionally, the reconstruction of fractured bone elements after accidents and the consumption of bone parts during surgical tumor excisions represent frequent clinical situations with deficient availability of healthy bone tissue for therapeutic transplantations. Epigenetic reprogramming represents a powerful technology for the generation of healthy patient-specific cells to replace or repair diseased or damaged tissue. The recent generation of induced pluripotent stem cells (iPSCs) is probably the most promising among these approaches dominating the literature of current stem cell research. It allows the generation of pluripotent stem cells from adult human skin cells from which potentially all cell types of the human body could be obtained. Another technique to produce clinically interesting cell types is direct lineage reprogramming (LR) with the additional advantage that it can be applied directly in vivo to reconstitute a damaged organ. Here, we want to present the two technologies of iPSCs and LR, to outline the current states of research, and to discuss possible strategies for their implementation in bone regeneration.
Color theory and design
Authors: Wegman Edward , Said Yasmin 
Published: February 2011

AbstractThis article, first published online on February 4, 2011 in Wiley Online Library (http://www.wileyonlinelibrary.com), has been revised at the request of the Editors‐in‐Chief and the Publisher. References and links have been added to aid the reader interested in following up on any technique. Please follow the link to the Supporting Information to view the original version of this article. http://onlinelibrary.wiley.com/doi/10.1002/wics.146/suppinfoIn this article, we discuss color theory and design with emphasis on use in statistical, scientific, and data visualization. Color theory is inextricably linked to the physiology of the human visual system, and color design is similarly inextricably linked to human perception. We discuss color perception in the human visual system. We then quantify color perception in terms of the Munsell System and the International Commission on Illumination (CIE) color space. We continue to discuss color design with a perspective on individuals with defective color perception and finally conclude with a discussion of design of color usage in presentations. WIREs Comp Stat 2011 3 104–117 DOI: 10.1002/wics.146This article is categorized under:

Statistical and Graphical Methods of Data Analysis > Statistical Graphics and Visualization
ggplot2
Authors: Wickham Hadley 
Published: February 2011

AbstractThis article discusses ggplot2, an open source R package, based on a grammatical theory of graphics. The underlying theory has been discussed in depth elsewhere so this article illustrates some of the consequences of the theory for creating new graphics, the importance of programmable graphics, and the rich ecosystem that has grown up around ggplot2. WIREs Comp Stat 2011 3 180–185 DOI: 10.1002/wics.147This article is categorized under:

Software for Computational Statistics > Software/Statistical Software
Statistical and Graphical Methods of Data Analysis > Statistical Graphics and Visualization
Data mining and crime analysis
Authors: Oatley Giles , Ewart Brian 
Published: February 2011

AbstractAn essential component of criminal investigation involves the interrogation of large databases of information held by police and other criminal justice agencies. Data mining and decision support systems have an important role to play in assisting human inference in this forensic domain that creates one of the most challenging decision‐making environments. Technologies range widely and include social network analysis, geographical information systems, and data mining technologies for clustering crimes, finding links between crime and profiling offenders, identifying criminal networks, matching crimes, generating suspects, and predicting criminal activity. This paper does not intend to cover the gamut of techniques available to the investigator of crime as this has been presented elsewhere (Oatley GC, Ewart BW, Zeleznikow J. Decision support systems for police: lessons from the application of data mining techniques to ‘soft’ forensic evidence. Artif Intell Law 2006, 14:35–100). Rather, the objective is to highlight issues of implementation and interpretation of the techniques available to the crime analyst. To this end, the authors draw from their experiences of working with real‐world crime databases (Oatley GC, Belem B, Fernandes K, Hoggarth E, Holland B, Lewis C, Meier P, Morgan K, Santhanam J, et al. The gang gun‐crime problem—solutions from social network theory, epidemiology, cellular automata, Bayesian networks and spatial statistics. Accepted: book chapter for IEEE publication Computational Forensics; 2008; Oatley GC, McGarry K, Ewart BW. Offender network metrics. WSEAS Trans Inf Sci Appl 2006, 3:2440–2448; Oatley GC, Ewart BW. Crimes analysis software: pins in maps, clustering and Bayes net prediction. Expert Syst Appl 2003, 25:569–588), involving gun and gang crime, fraud, terrorism, burglary, and retail crime. © 2011 John Wiley & Sons, Inc. WIREs Data Mining Knowl Discov 2011 1 147‐153 DOI: 10.1002/widm.6This article is categorized under:

Algorithmic Development > Spatial and Temporal Data Mining
Application Areas > Science and Technology
Application Areas > Society and Culture
Fundamental Concepts of Data and Knowledge > Human Centricity and User Interaction
Nanomaterial‐based advanced immunoassays
Authors: Hu Weihua , Li Chang Ming 
Published: February 2011

AbstractImmunoassay has been the main stream in clinic diagnostics and still attracts extensive research interest in recent years to develop reliable, fast, sensitive, and specific detection methods and platforms to expand its applications in various areas including proteomics, drug discovery, homeland security, food safety, environmental monitoring, and health care. With the dramatic progress in material science, nanotechnology, and bioconjugation techniques, a great diversity of nanomaterials with desirable superior properties have been designed, synthesized, and tailored to facilitate high‐performance detections for advanced immunoassays. This paper comprehensively reviews recent advances in nanomaterial‐based immunoassay technologies and particularly highlights newly developed strategies associated with interdisciplinary areas for performance enhancement and related mechanisms. The future perspectives of immunosensing technologies are also discussed. WIREs Nanomed Nanobiotechnol 2011 3 119–133 DOI: 10.1002/wnan.124This article is categorized under:

Diagnostic Tools > Biosensing
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Diagnostic Tools > In Vitro Nanoparticle-Based Sensing
Cauchois and Sénémaud Tables of wavelengths of X‐ray emission lines and absorption edges
Authors: Jonnard Philippe , Bonnelle Christiane 
Published: February 2011

AbstractWe present the Cauchois and Sénémaud Tables of X‐ray emission lines and absorption edges. They are written both in French and English. They were published in 1978 by Pergamon Press and are insufficiently known. However they are of large interest because of their completeness. They comprise the energies of all the K, L, M, N and O emission lines of natural elements from lithium up to uranium as well as the energies of satellite emissions and absorption discontinuities. The more intense lines of radio‐elements up to fermium (Z = 100) are also given. The Tables range from the hard X‐rays (122 keV, 0.01 nm) to the extreme ultra‐violet (12 eV, 102 nm). For each transition, the wavelength (Å and uX) and energy (eV and Ry) are given and references are indicated. The transitions are grouped by increasing wavelength (decreasing photon energy) and also by element and spectral series. We present, as an example, the use of the Tables to identify the emissions of the molybdenum L spectrum. We decided to scan the Cauchois and Sénémaud Tables and make them available for the scientific community. They are now available at the Website of our laboratory, http://www.lcpmr.upmc.fr/. Copyright © 2011 John Wiley & Sons, Ltd.
Son Preference in Indian Families: Absolute Versus Relative Wealth Effects
Authors: Gaudin Sylvestre 
Published: February 2011

Abstract
The desire for male children is prevalent in India, where son preference has been shown to affect fertility behavior and intrahousehold allocation of resources. Economic theory predicts less gender discrimination in wealthier households, but demographers and sociologists have argued that wealth can exacerbate bias in the Indian context. I argue that these apparently conflicting theories can be reconciled and simultaneously tested if one considers that they are based on two different notions of wealth: one related to resource constraints (absolute wealth), and the other to notions of local status (relative wealth). Using cross-sectional data from the 1998–1999 and 2005–2006 National Family and Health Surveys, I construct measures of absolute and relative wealth by using principal components analysis. A series of statistical models of son preference is estimated by using multilevel methods. Results consistently show that higher absolute wealth is strongly associated with lower son preference, and the effect is 20%–40% stronger when the household’s community-specific wealth score is included in the regression. Coefficients on relative wealth are positive and significant although lower in magnitude. Results are robust to using different samples, alternative groupings of households in local areas, different estimation methods, and alternative dependent variables.
A novel nonsense mutation of MSH2 gene in a Taiwanese family with hereditary nonpolyposis colorectal cancer
Authors: Chen Wen‐Chau , Lin Shao‐Chieh , Lee Jenq‐Chang 
Published: February 2011

AbstractHereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant inherited disease predisposing to the development of colorectal cancers and several other malignancies (endometrium, ovaries, stomach, small bowel, hepatobiliary, and urinary tract). HNPCC is caused by germline mutations in any of the mismatch repair genes. Mutations in MLH1 and MSH2 account for almost 90% of all identified ones. Here, we report a Taiwanese family with HNPCC and mutation analysis revealed a novel nonsense mutation (S611X) in MSH2 gene.
BOUNDS OF MULTIPLICATIVE CHARACTER SUMS WITH FERMAT QUOTIENTS OF PRIMES
Authors: SHPARLINSKI IGOR E. 
Published: February 2011

AbstractGiven a prime p, the Fermat quotient qp(u) of u with gcd (u,p)=1 is defined by the conditions We derive a new bound on multiplicative character sums with Fermat quotients qp(ℓ) at prime arguments ℓ.
A NOTE ON PARACOMPACT p-SPACES AND THE MONOTONE D-PROPERTY
Authors: GAO YIN-ZHU , SHI WEI-XUE 
Published: February 2011

AbstractFor any generalized ordered space X with the underlying linearly ordered topological space Xu, let X* be the minimal closed linearly ordered extension of X and $\tilde {X}$ be the minimal dense linearly ordered extension of X. The following results are obtained. (1)The projection mapping π:X*→X, π(〈x,i〉)=x, is closed.(2)The projection mapping $\phi : \tilde {X} \rightarrow X_u$, ϕ(〈x,i〉)=x, is closed.(3)X* is a monotone D-space if and only if X is a monotone D-space.(4)$\tilde {X}$ is a monotone D-space if and only if Xu is a monotone D-space.(5)For the Michael line M, $\tilde {M}$ is a paracompact p-space, but not continuously Urysohn.
Antipoverty Programmes in Venezuela
Authors: DAGUERRE ANNE 
Published: February 2011

AbstractThis article analyses Venezuelan antipoverty programmes under the presidency of Hugo Chávez, the leader of the ‘Bolivarian Revolution’ (1998–present). Support for poor people has become the government's trademark since the creation in 2002–03 of a series of emergency social programmes, the Missions. These programmes attend to the basic needs of low-income individuals in terms of nutrition, health and education. The Missions are characterised by a pattern of institutional bypassing which makes their long-term institutionalisation difficult. Do the Missions really introduce a break with previous social policies? To answer this question, we first analyse the evolution of the Venezuelan social state. Second, we review the development of the Missions, especially the MissionVuelvan Caras, nowChe Guevara, an active labour market programme. Third, we provide an assessment of the Social Missions and identify ruptures and continuities with past social assistance policies. The main contention is that the Missions exhibit a strong pattern of path dependency, despite the ideological and discursive ruptures that have attended the presidency of Hugo Chávez.