bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study
Authors: Bharadwaj Aditya S. , Abu-Much Arsalan , Maini Aneel S. , Zhou Zhipeng , Li Yanru , Batchelor Wayne B. , Grines Cindy L. , Baron Suzanne J. , Redfors Björn , Lansky Alexandra J. , Basir Mir B. , O’Neill William W. 
Published: May 2024

BACKGROUND:
Prior studies have found that patients with chronic kidney disease (CKD) have worse outcomes following percutaneous coronary intervention (PCI). There are no data about patients with advanced CKD undergoing Impella-supported high-risk PCI. We, therefore, aimed to evaluate angiographic characteristics and clinical outcomes in patients with CKD who received Impella-supported high-risk PCI as part of the catheter-based ventricular assist device PROTECT III study (A Prospective, Multi-Center, Randomized Controlled Trial of the IMPELLA RECOVER LP 2.5 System Versus Intra Aortic Balloon Pump [IABP] in Patients Undergoing Non Emergent High Risk PCI).

METHODS:
Patients enrolled in the PROTECT III study were analyzed according to their baseline estimated glomerular filtration rate (eGFR). The primary outcome was 90-day major adverse cardiovascular and cerebrovascular events (the composite of all-cause death, myocardial infarction, stroke/transient ischemic attack, and repeat revascularization).

RESULTS:

Of 1237 enrolled patients, 1052 patients with complete eGFR baseline assessment were evaluated: 586 with eGFR ≥60 mL/min per 1.73 m
2
, 190 with eGFR ≥45 to <60, 105 with eGFR ≥30 to <45, and 171 with eGFR <30 or on dialysis. Patients with lower eGFR (all groups with eGFR <60) were more frequently females and had a higher prevalence of hypertension, diabetes, anemia, and peripheral artery disease. The baseline Synergy Between PCI With Taxus and Cardiac Surgery score was similar between groups (28.2±12.6 for all groups). Patients with lower eGFR were more likely to have severe coronary calcifications and higher usage of atherectomy. There were no differences in individual PCI–related coronary complications between groups, but the rates of overall PCI complications were less frequent among patients with lower eGFR. Major adverse cardiovascular and cerebrovascular events at 90 days and 1-year mortality were significantly higher among patients with eGFR <30 mL/min per 1.73 m
2
or on dialysis.

CONCLUSIONS:

Patients with advanced CKD undergoing Impella-assisted high-risk PCI tend to have higher baseline comorbidities, severe coronary calcification, and higher atherectomy usage, yet CKD was not associated with a higher rate of immediate PCI–related complications. However, 90-day major adverse cardiovascular and cerebrovascular events and 1-year mortality were significantly higher among patients with eGFR<30 mL/min per 1.73 m
2
or on dialysis. Future studies of strategies to improve intermediate and long-term outcomes of these high-risk patients are warranted.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04136392.
Infliximab Limits Injury in Myocardial Infarction
Authors: Livia Christopher , Inglis Sara , Crespo‐Diaz Ruben , Rizzo Skylar , Mahlberg Ryan , Bagwell Monique , Hillestad Matthew , Yamada Satsuki , Meenakshi Siddharthan Dhivya Vadhana , Singh Raman Deep , Li Xing , Arrell D. Kent , Stalboerger Paul , Witt Tyra , El Sabbagh Abdallah , Rihal Munveer , Rihal Charanjit , Terzic Andre , Bartunek Jozef , Behfar Atta 
Published: May 2024

Background
The purpose of this study was to investigate a therapeutic approach targeting the inflammatory response and consequent remodeling from ischemic myocardial injury.

Methods and Results

Coronary thrombus aspirates were collected from patients at the time of ST‐segment–elevation myocardial infarction and subjected to array‐based proteome analysis. Clinically indistinguishable at myocardial infarction (MI), patients were stratified into vulnerable and resilient on the basis of 1‐year left ventricular ejection fraction and death. Network analysis from coronary aspirates revealed prioritization of tumor necrosis factor‐α signaling in patients with worse clinical outcomes. Infliximab, a tumor necrosis factor‐α inhibitor, was infused intravenously at reperfusion in a porcine MI model to assess whether infliximab‐mediated immune modulation impacts post‐MI injury. At 3 days after MI (n=7), infliximab infusion increased proregenerative M2 macrophages in the myocardial border zone as quantified by immunofluorescence (24.1%±23.3% in infliximab versus 9.29%±8.7% in sham;
P
<0.01). Concomitantly, immunoassays of coronary sinus samples quantified lower troponin I levels (41.72±7.34 pg/mL versus 58.11±10.75 pg/mL;
P
<0.05) and secreted protein analysis revealed upregulation of injury‐modifying interleukin‐2, ‐4, ‐10, ‐12, and ‐18 cytokines in the infliximab‐treated cohort. At 4 weeks (n=12), infliximab treatment resulted in significant protective influence, improving left ventricular ejection fraction (53.9%±5.4% versus 36.2%±5.3%;
P
<0.001) and reducing scar size (8.31%±10.9% versus 17.41%±12.5%;
P
<0.05).

Conclusions
Profiling of coronary thrombus aspirates in patients with ST‐segment–elevation MI revealed highest association for tumor necrosis factor‐α in injury risk. Infliximab‐mediated immune modulation offers an actionable pathway to alter MI‐induced inflammatory response, preserving contractility and limiting adverse structural remodeling.
Racial Disparities in Blood Pressure at Time of Acute Ischemic Stroke Presentation: A Population Study
Authors: Aziz Yasmin N. , Sucharew Heidi , Stanton Robert J. , Alwell Kathleen , Ferioli Simona , Khatri Pooja , Adeoye Opeolu , Flaherty Matthew L. , Mackey Jason , De Los Rios La Rosa Felipe , Martini Sharyl R. , Mistry Eva A. , Coleman Elisheva , Jasne Adam S. , Slavin Sabreena J. , Walsh Kyle , Star Michael , Ridha Mohamed , Ades Laura M. C. , Haverbusch Mary , Demel Stacie L. , Woo Daniel , Kissela Brett M. , Kleindorfer Dawn O. 
Published: May 2024

Background
Hypertension is a stroke risk factor with known disparities in prevalence and management between Black and White patients. We sought to identify if racial differences in presenting blood pressure (BP) during acute ischemic stroke exist.

Methods and Results

Adults with acute ischemic stroke presenting to an emergency department within 24 hours of last known normal during study epochs 2005, 2010, and 2015 within the Greater Cincinnati/Northern Kentucky Stroke Study were included. Demographics, histories, arrival BP, National Institutes of Health Stroke Scale score, and time from last known normal were collected. Multivariable linear regression was used to determine differences in mean BP between Black and White patients, adjusting for age, sex, National Institutes of Health Stroke Scale score, history of hypertension, hyperlipidemia, smoking, stroke, body mass index, and study epoch. Of 4048 patients, 853 Black and 3195 White patients were included. In adjusted analysis, Black patients had higher presenting systolic BP (161 mm Hg [95% CI, 159–164] versus 158 mm Hg [95% CI, 157–159],
P
<0.01), diastolic BP (86 mm Hg [95% CI, 85–88] versus 83 mm Hg [95% CI, 82–84],
P
<0.01), and mean arterial pressure (111 mm Hg [95% CI, 110–113] versus 108 mm Hg [95% CI, 107–109],
P
<0.01) compared with White patients. In adjusted subanalysis of patients <4.5 hours from last known normal, diastolic BP (88 mm Hg [95% CI, 86–90] versus 83 mm Hg [95% CI, 82–84],
P
<0.01) and mean arterial pressure (112 mm Hg [95% CI, 110–114] versus 108 mm Hg [95% CI, 107–109],
P
<0.01) were also higher in Black patients.

Conclusions
This population‐based study suggests differences in presenting BP between Black and White patients during acute ischemic stroke. Further study is needed to determine whether these differences influence clinical decision‐making, outcome, or clinical trial eligibility.
Does Distance Matter? How Physical and Social Distance Shape Our Perceived Obligations to Others
Authors: Marshall Julia , Wilks Matti 
Published: May 2024

Abstract
Debates within moral philosophy have long centered on the question of whether we are more obligated to help those close to us compared to those who are farther away. Despite these debates, we have little understanding of our psychological intuitions about these issues. In the current study, we presented adults and children (5- to 9-year-olds) in the United States (N = 406) with hypothetical scenarios involving pairs of socially and physically close and far strangers and asked about their obligations to help one another. In general, younger children (∼6-year-olds) were more inclined to describe strangers as obligated to help one another compared to older children (∼8-year-olds) and adults. For physical distance, we documented an age-related trend where younger children were less inclined to consider physical distance when ascribing obligations to help compared to older children and adults. For social distance, we found different results depending on how social distance was manipulated. In Study 1, where social distance was manipulated via mere similarity, we found an age-related effect where adults, but not younger or older children, judged that individuals are more obligated to help socially close others relative to far ones. In Study 2, where social distance was manipulated via explicit group membership, we did not find an age trend. Instead, participants generally described individuals as more obligated to help an ingroup member relative to an outgroup one. These results demonstrate that the tendency to deny obligations towards distant others is a belief that emerges relatively late in development.
Examining the Impact of Reading Fluency on Lexical Decision Results in French 6th Graders
Authors: Lubineau Marie , Watkins Cassandra Potier , Glasel Hervé , Dehaene Stanislas 
Published: May 2024

Abstract
Purpose: How does lexical decision behavior vary in students with the same grade level (all students were in their first year of middle-school), but different levels of reading fluency? Here, we tested a prediction of the dual-route model: as fluency increases, variations in the results may reflect a decreasing reliance on decoding and an increasing reliance on the lexical route. Method: 1,501 French 6th graders passed a one-minute speeded reading-aloud task evaluating fluency, and a ten-minute computerized lexical decision task evaluating the impact of lexicality, length, word frequency and pseudoword type. Results: As predicted, the word length effect varied dramatically with reading fluency, with the least fluent students showing a length effect even for frequent words. The frequency effect also varied, but solely in proportion to overall reading speed, suggesting that frequency affects the decision stage similarly in all readers, while length disproportionately impacts poor readers. Response times and errors were also affected by pseudoword type (e.g., letter substitutions or transpositions), but these effects showed minimal variation with fluency. Overall, lexical decision variables were excellent predictors of reading fluency (r = 0.62). Conclusion: Our results highlight the variability in middle-school reading ability and describe how a simple lexical decision task can be used to assess students’ mental lexicon (vocabulary) and the automatization of reading skills.
A multilevel analysis of data quality for formal software citation
Authors: Schindler David , Hossain Tazin , Spors Sascha , Krüger Frank 
Published: May 2024

Abstract
Software is a central part of modern science, and knowledge of its use is crucial for the scientific community with respect to reproducibility and attribution of its developers. Several studies have investigated in-text mentions of software and its quality, while the quality of formal software citations has only been analyzed superficially. This study performs an in-depth evaluation of formal software citation based on a set of manually annotated software references. It examines which resources are cited for software usage, to what extent they allow proper identification of software and its specific version, how this information is made available by scientific publishers, and how well it is represented in large-scale bibliographic databases. The results show that software articles are the most cited resource for software, while direct software citations are better suited for identification of software versions. Moreover, we found current practices by both publishers and bibliographic databases to be unsuited to represent these direct software citations, hindering large-scale analyses such as assessing software impact. We argue that current practices for representing software citations—the recommended way to cite software by current citation standards—stand in the way of their adoption by the scientific community, and urge providers of bibliographic data to explicitly model scientific software.
A critical review of large language models: Sensitivity, bias, and the path toward specialized AI
Authors: Hajikhani Arash , Cole Carolyn 
Published: May 2024

Abstract
This paper examines the comparative effectiveness of a specialized compiled language model and a general-purpose model such as OpenAI’s GPT-3.5 in detecting sustainable development goals (SDGs) within text data. It presents a critical review of large language models (LLMs), addressing challenges related to bias and sensitivity. The necessity of specialized training for precise, unbiased analysis is underlined. A case study using a company descriptions data set offers insight into the differences between the GPT-3.5 model and the specialized SDG detection model. While GPT-3.5 boasts broader coverage, it may identify SDGs with limited relevance to the companies’ activities. In contrast, the specialized model zeroes in on highly pertinent SDGs. The importance of thoughtful model selection is emphasized, taking into account task requirements, cost, complexity, and transparency. Despite the versatility of LLMs, the use of specialized models is suggested for tasks demanding precision and accuracy. The study concludes by encouraging further research to find a balance between the capabilities of LLMs and the need for domain-specific expertise and interpretability.
Linking science with media and policy: The case of academics in Flanders, Belgium
Authors: Jonker Hans , Vanlee Florian 
Published: May 2024

Abstract
There is a growing expectation for academics to go public, that is, to actively engage with the media and supply policy advice for decision-makers. Data showing these interactions are scarce. By linking data from FRIS, BelgaPress, and Overton, this study reveals a first snapshot of academics’ media mentions and policy citations for all active academics from Dutch-speaking universities in Belgium. Exploratory analysis reveals distinct sector differences, with academics from Social sciences, Medical, and Health sciences being most visible. A small minority of mostly male academics featured very often in media as media figures, contrasted by much more discrete policy pillars whose publications were cited often but hardly featured in traditional media.
Knowledge Access: The Effects of Carnegie Libraries on Innovation
Authors: Berkes Enrico , Nencka Peter 
Published: May 2024

Abstract
Between 1883 and 1919, Andrew Carnegie funded the construction of over 1,500 public libraries across the United States, reducing the costs of accessing knowledge for millions. We study the effect of these libraries on innovation. Patenting in recipient places increased on average by 10–12 percent in the 20 years following library construction relative to a novel control group of cities that applied for but did not build libraries. We show that access to scientific knowledge and increased collaboration opportunities are possible mechanisms.
Beyond the Confines of Compliance and Virtue: Honing a Set of Global Ethics for South Africa and the United States of America
Authors: Hilliard Victor G. 
Published: May 2024

Another practical frontier of ethics is global ethics which this article examines in terms of South Africa and the United States of America. Both nations wish to entrench ethics and ethical behaviour in their societies in general and their public sectors in particular. The author devoted special attention to the notion of a global ethic as a possible alternative approach to embedding ethical behaviour in the two countries. Notwithstanding the glaring differences between the USA and South Africa in terms of socioeconomic development, few can dispute the need for an ethical society in both nations. He argues that the proper yardstick to judge American and South Africa's morality will be, or should be, a global one, especially if South Africa, just as the USA, hopes to compete on a global scale for trade, investment, and other types of bilateral or multilateral agreements. There is a need for a trans-cultural corporate ethic which is a business and governmental ethic that is acceptable across the borders, traverses and transcends nations and nationalities. A huge development in post-apartheid South Africa is the focus on th global ethics that is a honing and refining of a set of “universal” ethics for the “new” South Africa (Hilliard and Kemp, 2000c). South Africa is now functioning and doing business in a global environment; since 1994 it has once more gained legitimacy in the international arena. In the wake of large-scale globalisation of all facets of human endeavour, speculating about the need for universal, global or cosmic values and norms is appropriate. If judged by international development, South Africa may, consequently, not want to be isolated from
Asbestos exposures associated with the use and handling of drilling mud additives
Authors: Anderson Evan , Holton Michael , Ellis Jennifer , Meyler Shannon , Adams Robert , Daniel Gina 
Published: May 2024

This paper summarizes historical asbestos exposure data collected during the handling of short-fiber chrysotile asbestos that was used as an additive to drilling fluid in oil and gas exploration. A total of 1171 industrial hygiene (IH) personal and area air samples were collected and analyzed from more than 20 drilling rigs between 1972 and 1985. The dataset consists of 1097 short-term samples (<240 min) with more than 80% having sample durations less than 30 min. Average airborne fiber concentrations measured during asbestos handling activities ranged from 0.62 f/cc to 3.39 f/cc using phase-contrast microscopy (PCM). An additional 14 samples were considered long-term samples (>240 min) and there were 60 samples with no reported sample duration. Eight-hour time-weighted average (8-h TWA) results, calculated using short-term samples, along with long-term samples greater than 240 min, did not exceed contemporaneous Occupational Safety and Health Administration (OSHA) permissible exposure limits (PELs). This analysis fills a data gap in the evaluation of asbestos exposures from the use of drilling mud additives (DMAs) that contained chrysotile asbestos.
Critical Elements in the Design of Culturally Appropriate Interventions Intended to Reduce Health Disparities: Immunization Rates among Hispanic Seniors in New Mexico
Authors: Levy Celinda , Carter Susan , Priloutskaya Galina , Gallegos Gertrude 
Published: May 2024

The importance of immunization in protecting seniors against influenza and pneumonia has long been recognized. Nevertheless, immunization rates among Medicare beneficiaries continue to fall short of what is both desirable and achievable. The problem is even more acute among certain racial and ethnic groups in the United States within which rates are below the rate for the country as a whole. This is true in New Mexico where 40 percent of the population is estimated to be Hispanic. As part of its work on behalf of the Centers for Medicare & Medicaid Services (CMS), the New Mexico Medical Review Association (NMMRA) undertook a project aimed both at reducing the disparities that exist in immunization status between the Hispanic and non-Hispanic population in the state and attempting to increase overall rates in the state for all groups. Developing interventions to reduce disparaties in immunization rates between Hispanic seniors and the rest of the senior population requires more than a straightforward review of the literature and must take into account not only the cultural differences that exist between Hispanics and non-Hispanics but, certainly, in the case of New Mexico, it must attempt to understand the richness and diversity that exists within the Hispanic communities across the state. To do otherwise runs the risk of designing interventions that are at best ineffective and at worst culturally insensitive and potentially damaging to future efforts to improve health status. This article describes the process undertaken by NMMRA, a Medicare Quality Improvement Organization (QIO), to collect qualitative data from three culturally different groups of Hispanics in New Mexico. The data are used to design interventions that will increase immunization rates for all Hispanics in New Mexico.
Mergers and the New Workplace: The Effects of a Merger of two Emergency Departments on Nursing Staff
Authors: Lees Martin , Taylor Gina 
Published: May 2024

Even small mergers have big consequences. This case study demonstrates the complex nature of organizational change found even in small organizational subunits and provides important insight for managers and leaders who have completed or are considering such mergers. The study examined the amalgamation of two emergency departments. Quantitative and qualitative techniques were used to analyze the planning, implementation, and outcomes of this amalgamation on the nursing staff. This case study draws upon the literature pertaining to change survivor's syndrome, prescribed approaches to change, and the difficulties in changing cultures and making complex decisions. Change in hospitals has been shown to have negative consequences for nurses. The goal of this study was to examine in greater detail what aspects of change are associated with these effects. The findings suggest that the planning of the amalgamation was consistent with rational decision-making. The goals of changing to a single emergency unit and cost savings were achieved. However, the nurses experienced stress due to the pace of work and the physical layout of the newly renovated department. The findings also suggest that personal-level problems that the nurses experienced were consistent with the consequences of survivor's syndrome, the psychological contract, and communication issues. It was recommended that the organization undertake initiative to alleviate these stresses.