bluuebunny/crossref_metadata_2025_split huggingface dataset:
IRAK-M Removal Counteracts Dendritic Cell Vaccine Deficits in Migration and Longevity
Authors: Turnis Meghan E. , Song Xiao-Tong , Bear Adham , Foster Aaron E. , Gottschalk Stephen , Brenner Malcolm K. , Chen Si-Yi , Rooney Cliona M. 
Published: September 2010

Abstract
To function optimally as vaccines, dendritic cells (DCs) must actively migrate to lymphoid organs and maintain a viable, mature state for sufficient time to effectively present their Ag to cognate T cells. Unfortunately, mature DCs rapidly lose viability and function after injection, and only a minority leaves the vaccine site and migrates to lymph nodes. We show that all of these functions can be enhanced in DCs by removal of IL-1R–associated kinase M (IRAK-M). We found that IRAK-M is induced in DCs by TLR ligation and that its absence from these cells leads to increased activation of the p38-MAPK and NF-κB pathways, which, in turn, improves DC migration to lymph nodes, increases their longevity, and augments their secretion of Th1-skewing cytokines and chemokines. These biological effects have immunological consequences. IRAK-M−/− DCs increase the proliferation and activation of Ag-specific T cells, and a single vaccination with Ag-pulsed, LPS-matured IRAK-M−/− DCs eliminates established tumors and prolongs the survival of EG7 or B16.f10 tumor-bearing mice, without discernible induction of autoimmune disease. Thus, manipulation of IRAK-M levels can increase the potency of DC vaccines by enhancing their Ag-presenting function, migration, and longevity.
NF-κB Links CO2 Sensing to Innate Immunity and Inflammation in Mammalian Cells
Authors: Cummins Eoin P. , Oliver Kathryn M. , Lenihan Colin R. , Fitzpatrick Susan F. , Bruning Ulrike , Scholz Carsten C. , Slattery Craig , Leonard Martin O. , McLoughlin Paul , Taylor Cormac T. 
Published: September 2010

Abstract
Molecular O2 and CO2 are the primary substrate and product of aerobic metabolism, respectively. Levels of these physiologic gases in the cell microenvironment vary dramatically both in health and in diseases, such as chronic inflammation, ischemia, and cancer, in which metabolism is significantly altered. The identification of the hypoxia-inducible factor led to the discovery of an ancient and direct link between tissue O2 and gene transcription. In this study, we demonstrate that mammalian cells (mouse embryonic fibroblasts and others) also sense changes in local CO2 levels, leading to altered gene expression via the NF-κB pathway. IKKα, a central regulatory component of NF-κB, rapidly and reversibly translocates to the nucleus in response to elevated CO2. This response is independent of hypoxia-inducible factor hydroxylases, extracellular and intracellular pH, and pathways that mediate acute CO2-sensing in nematodes and flies and leads to attenuation of bacterial LPS-induced gene expression. These results suggest the existence of a molecular CO2 sensor in mammalian cells that is linked to the regulation of genes involved in innate immunity and inflammation.
Supernumerary impacted teeth in a patient with SOX2 anophthalmia syndrome
Authors: Numakura Chikahiko , Kitanaka Sachiko , Kato Mitsuhiro , Ishikawa Shigeo , Hamamoto Yoshioki , Katsushima Yuriko , Kimura Toshiyuki , Hayasaka Kiyoshi 
Published: September 2010

AbstractSOX2 anophthalmia syndrome characteristically presents as anophthalmia or microphthalmia, with various extraocular symptoms, such as hypogonadotropic hypogonadism, brain anomaly, and esophageal abnormalities. In this report, we describe a patient with SOX2 anophthalmia syndrome complicated with a dental anomaly, multiple supernumerary impacted teeth, and persistence of deciduous teeth. Multiple supernumerary teeth are usually not solitary symptoms, but indicate systemic syndrome such as cleidocranial dysplasia. In odontogenesis, many transcriptional factors, such as BMPs, FGFs, and Wnts, play significant roles and SOX2 is known to interact with some of them. The role of SOX2 in dental development remains unknown, however, multiple supernumerary teeth can be considered as extraocular symptoms of SOX2 anophthalmia syndrome, rather than the coincidence of two rare diseases. © 2010 Wiley‐Liss, Inc.
Chimerism resulting from parthenogenetic activation and dispermic fertilization
Authors: Winberg Johanna , Gustavsson Peter , Lagerstedt‐Robinson Kristina , Blennow Elisabeth , Lundin Johanna , Iwarsson Erik , Nordenström Anna , Anderlid Britt‐Marie , Bondeson Marie‐Louise , Nordenskjöld Agneta , Nordgren Ann 
Published: September 2010

AbstractWhole‐body human chimerism is the result of two zygotes giving rise to one individual, and is a rarely detected condition. We have studied the molecular background and discuss the likely mechanism for the chimerism in a patient with a 46,XX/47,XY,+14 karyotype and ambiguous genitalia, cryptorchidism, pigment anomalies, and normal psychomotor development. We have used karyotyping, interphase‐FISH and array‐CGH analysis as well as molecular analysis of polymorphic markers from 48 loci in order to define the origin and percentage of 47,XY,+14 cells in different tissues. Based on the findings of two paternal alleles and the detection of homozygous maternal alleles without evidence of crossing‐over, and the fact that four alleles were never detected, our results indicate that the chimerism in our patient is the result of dispermic fertilization of a parthenogenetically activated oocyte. Our report underlines that cytogenetic findings suggesting mosaicism might actually indicate chimerism as an underlying mechanism in patients. It also highlights the difficulties in predicting the clinical outcome in patients with genetic aberrations in mosaic or chimeric form. © 2010 Wiley‐Liss, Inc.
Tetrasomy 18p: Report of the molecular and clinical findings of 43 individuals
Authors: Sebold Courtney , Roeder Elizabeth , Zimmerman Marsha , Soileau Bridgette , Heard Patricia , Carter Erika , Schatz Martha , White W. Abraham , Perry Brian , Reinker Kent , O'Donnell Louise , Lancaster Jack , Li John , Hasi Minire , Hill Annice , Pankratz Lauren , Hale Daniel E. , Cody Jannine D. 
Published: September 2010

AbstractThus far, the phenotype of tetrasomy 18p has been primarily delineated by published case series and reports. Findings reported in more than 25% of these cases include neonatal feeding problems, growth retardation, microcephaly, strabismus, muscle tone abnormalities, scoliosis/kyphosis, and variants on brain MRI. Developmental delays and cognitive impairment are universally present. The purpose of this study was to more fully describe tetrasomy 18p at both the genotypic and the phenotypic levels. Array CGH was performed on 43 samples from individuals with tetrasomy 18p diagnosed via routine karyotype. The medical records of 42 of these 43 individuals were reviewed. In order to gain additional phenotypic data, 31 individuals with tetrasomy 18p underwent a series of clinical evaluations at the Chromosome 18 Clinical Research Center. Results from the molecular analysis indicated that 42 of 43 samples analyzed had 4 copies of the entire p arm of chromosome 18; one individual was also trisomic for a section of proximal 18q. The results of the medical records review and clinical evaluations expand the phenotypic description of tetrasomy 18p to include neonatal jaundice and respiratory distress; recurrent otitis media; hearing loss; seizures; refractive errors; constipation and gastroesophageal reflux; cryptorchidism; heart defects; and foot anomalies. Additional findings identified in a small number of individuals include hernias, myelomeningocele, kidney defects, short stature, and failure to respond to growth hormone stimulation testing. Additionally, a profile of dysmorphic features is described. Lastly, a series of clinical evaluations to be considered for individuals with tetrasomy 18p is suggested. © 2010 Wiley‐Liss, Inc.
ChemInform Abstract: On the Influence of Substitutions by Ions of the Same Charge on Luminescence of Pentastrontium Chloridephosphate Activated by Divalent Europium.
Authors: NOETZOLD D. , HERZOG G. , HENKE I. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Positive‐Temperature‐Coefficient Effect in Graphite‐Cristobalite Composites.
Authors: OTA T. , YAMAI I. , TAKAHASHI J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: CVD of Y2O3 from YCl3‐CO2‐H2‐Ar Gas Mixtures: An Experimental Study.
Authors: SIPP E. , LANGLAIS F. , NASLAIN R. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: X‐Ray, Transport, Magnetic, Moessbauer and Catalytic Studies of the System Zn1‐xCuxMnFeO4.
Authors: DUBE G. R. , DARSHANE V. S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Step Transformation of α‐Amino Acids (I) to α‐Amino Aldehydes (II) Effected by Electrochemical Oxidation of Ph3P.
Authors: MAEDA H. , MAKI T. , OHMORI H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effects of Substitution in Perovskites La2‐xSrxNiO4‐λ on Their Catalytic Action for the Nitric Oxide + Carbon Monoxide Reaction.
Authors: LADAVOS A. K. , POMONIS P. J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effect of Support Material on the Catalytic Combustion of Diesel Soot Particulates.
Authors: VAN DOORN J. , VARLOUD J. , MERIAUDEAU P. , PERRICHON V. , CHEVRIER M. , GAUTHIER C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lipase‐Mediated Optical Resolution of Bicyclic Secondary Carbinols.
Authors: MELTZ M. , SACCOMANO N. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microbiological and Chemical Methods in the Asymmetric Oxidation of Sulfides: A Comparative Study for the Preparation of (S)‐Vinyl Sulfoxides.
Authors: ROSSI C. , FAUVE A. , MADESCLAIRE M. , ROCHE D. , DAVIS F. A. , REDDY R. T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enzymatic Oxidation of Methyl Groups on Heteroarenes: A Versatile Method for the Synthesis of Heteroaromatic Carboxylic Acids.
Authors: KIENER A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biotransformation of (‐)‐α‐Bisabolol to 6‐Methyl‐2‐(4′‐ methylcyclohexan‐1′‐yl)‐2,5‐epoxyheptane‐3′,4′,6‐triol by Aspergillus niger.
Authors: MIYAZAWA M. , FUNATSU Y. , KAMEOKA H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: π‐Acceptor Induced Reactions: Radicals vs. Ions in Thermally Induced Ether Cleavage Reactions.
Authors: PENN J. H. , DENG D.‐L. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple Method for the Synthesis of Cyclic α‐Amino Acids.
Authors: KOTHA S. , KUKI A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry and Kinetics of Singlet (Pentafluorophenyl)nitrene.
Authors: POE R. , SCHNAPP K. , YOUNG M. J. T. , GRAYZAR J. , PLATZ M. S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Kinetics of the Reactions of C2H with C2H2, H2, and D2.
Authors: KOSHI M. , NISHIDA N. , MATSUI H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aminoalkylbenzotriazoles: Reagents for the Aminoalkylation of Electron Rich Heterocycles.
Authors: KATRITZKY A. R. , YANG Z. , LAM J. N. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Alkaline Alkylation of 4‐Hydroxyimino‐1‐pentanol.
Authors: NIKOLAEVA A. D. , NIKOLAEVA L. V. , MOSKO V. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Production of Branched‐Chain Hydrocarbons via Isosynthesis.
Authors: SOFIANOS A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Synthesis of Higher Alcohols Using Modified Cu/ZnO/Al2O3 Catalysts.
Authors: SLAA J. C. , VAN OMMEN J. G. , ROSS J. R. H. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation and Regio‐ and Diastereoselective Reactions of Allylic Zirconium Reagents from Allylic Ether Derivatives.
Authors: ITO H. , TAGUCHI T. , HANZAWA Y. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Aldol Reaction of Silyl Enol Ethers with Aldehydes in Aqueous Media.
Authors: KOBAYASHI S. , HACHIYA I. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Double Michael Addition Reactions of Bischalcones.
Authors: REDDY D. B. , PADMAVATHI V. , REDDY M. M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Friedel‐Crafts Approach to Electron Deficient Cyclic α‐Amino Acids.
Authors: KOTHA S. , ANGLOS D. , KUKI A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Some 5‐Substituted Indoles.
Authors: YANG Y. , MARTIN A. R. , NELSON D. L. , REGAN J. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 1‐(3‐Methyl‐1‐pyrazolyl)anthraquinone.
Authors: PEREVALOV V. P. , BARYSHNENKOVA L. I. , CHOI K. S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Benzo(a)acridines by a Photochemical Route.
Authors: JAYABALAN L. , SHANMUGAM P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Immobilized Crown Ethers with Macrocycles Remote from the Polymeric Matrix.
Authors: ORLOVSKII V. V. , LYASHCHENKO O. O. , ZLOTSKII S. S. , RAKHMANKULOV D. L. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Condensed Heterocycles. Part 24. Synthesis of Novel Condensed 1,2,3‐Selenadiazoles.
Authors: SHARMA K. S. , SINGH S. P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Surface Nature of Grignard Reagent Formation: Cyclopropylmagnesium Bromide.
Authors: WALBORSKY H. M. , ZIMMERMANN C. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unusual Cassanes from a Chamaecrista Species
Authors: BARBA B. , DIAZ J. G. , GOEDKEN V. L. , HERZ W. , DOMINGUEZ X. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Studies in Sesquiterpenes. Part 60. Reversion of Longipinane to Himachalane System: Revision of Structure of Isocentdarol.
Authors: SHASTRI M. H. , DEV S. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Improved Synthesis of (p‐Phosphono and p‐Sulfo)methylphenylalanine. Resolution of (p‐Phosphono‐, p‐Sulfo‐, p‐Carboxy‐ and p‐N‐ Hydroxycarboxamido‐)methylphenylalanine.
Authors: GARBAY‐JAUREGUIBERRY C. , MCCORT‐TRANCHEPAIN I. , BARBE B. , FICHEUX D. , ROQUES B. P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.