bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different paradigms for dealing with urban water issues, using new technological and governance solutions, learning from Chinese, Indian and European experiences
Authors: van Dijk Meine Pieter 
Published: May 2024

ABSTRACT
Three paradigms to deal with urban water issues are compared. The analysis focuses on their definition and objectives, the role of different stakeholders, the issues they deal with, and the possible solutions suggested. The paradigms differ in scope (from the narrow focus of the sponge city paradigm to the broad goals of eco-city paradigm) and in terms of the governance structures used to coordinate different stakeholders. The smart and sponge paradigms mainly use existing government structures. In the eco-cities approach, the citizens want to be involved through newly created governance structures. Smart and eco-city initiatives emphasize the involvement of stakeholders, while in the sponge cities approach, the initiative is often taken by the local government. Finally, in terms of expected solutions, the paradigms want to create eco- or healthy cities or improve water management to create a more healthy urban environment. After identifying the issue, alternative water-related technologies are available, like generating energy from wastewater or separating grey and brown water. Cities require different governance structures, and managing information flows in an integrated way to solve water and other issues. The experience in Europe, China, and India may help other cities choose the right paradigm.
Endothelial-specific Enhancer as a Cis Element of PLAUR Regulation
by TNF-alpha, IL-1beta, and VEGF
Authors: Penkov Dmitry , Beloglazova Irina , Parfyonova Yelena 
Published: May 2024

Abstract:
The expression of human PLAUR gene, which encodes the urokinase plasminogen activator receptor
(uPAR), is cell- and process-specific and elevated in inflammation, cancer and senescence. Its tight regulation
is achieved by regulatory elements in the gene locus, such as the promoter and several enhancers. The promoter
activity is not specific to a particular cell type and has been described earlier. The proximal enhancer is
endothelial-specific and responsible for the PLAUR expression pattern in endothelial cells. In this study we described
the enhancer activity and its cis-regulatory elements based on the published data. We showed a possible
connection of the enhancer activity with known cellular phenotypes.
Recent Developments of Hybrid Fluorescence Techniques: Advances in
Amyloid Detection Methods
Authors: A. Miraclin Prasanna , Sen Priyankar 
Published: May 2024

:
Amyloid fibrils are formed from various pathological proteins. Monitoring their aggregation
process is necessary for early detection and treatment. Among the available detection techniques,
fluorescence is simple, intuitive, and convenient due to its sensitive and selective mode of
detection. It has certain disadvantages like poor photothermal stability and detection state limitation.
Research has focused on minimising the limitation by developing hybrid fluorescence techniques.
This review focuses on the two ways fluorescence (intrinsic and extrinsic) has been used
to monitor amyloid fibrils. In intrinsic/label free fluorescence: i) The fluorescence emission
through aromatic amino acid residues like phenylalanine (F), tyrosine (Y) and tryptophan (W) is
present in amyloidogenic peptides/protein sequence. And ii) The structural changes from alpha helix
to cross-β-sheet structures during amyloid formation contribute to the fluorescence emission.
The second method focuses on the use of extrinsic fluorophores to monitor amyloid fibrils i) organic
dyes/small molecules, ii) fluorescent tagged proteins, iii) nanoparticles, iv) metal complexes
and v) conjugated polymers. All these fluorophores have their own limitations. Developing them
into hybrid fluorescence techniques and converting it into biosensors can contribute to early detection
of disease.
Challenges to Compliance and Adherence to Personal Hygiene and Food Safety Among Foodservice Workers in Hospitals of Mogalakwena Municipality, Limpopo Province
Authors: Mphasha Mabitsela Hezekiel , Tleane Rosina , Sibiya Kella , phamela Sithole , Nkwane Thapelo 
Published: May 2024

Background:
Foodborne illnesses could result from food handlers acquiring bacteria that make them dangerous for humans to consume. Non-adherence to personal hygiene and food safety can impact how well patients' conditions are managed and aggravate illnesses during hospital stay. Therefore, this study seeks to explore factors that may impact adherence to personal hygiene and food safety among hospital food service workers.

Methods:
Qualitative exploratory study design was used to extract data from food handlers at Mokopane and Voortrekker hospitals in Mogalakwena municipality of Limpopo province, South Africa. Twenty-one participants were purposively sampled, and face-to-face interviews were conducted using voice recorders and field notes for non-verbal cues. Tesch’s eight steps, inductive, descriptive, and open coding techniques were used to analyse data.

Results:
Factors reportedly affecting personal hygiene and food safety include knowledge of the importance of adherence to personal hygiene and food safety, personal preferences and attitude towards personal hygiene, and lack of uniform and inspection. Non-adherence is affected by cultural norms regarding the wearing of wedding rings and bracelets on the wrist.

Conclusion:
This study recommends regular internal and external food safety compliance and monitoring. The leadership of the hospital's food service department should be strengthened, and food handlers should get regular in-service training.
Screen-based Simulation Supporting Problem-based Learning to Improve Football Tactics
Authors: Jia Teng , Sitthiworachart Jirarat , Morris John 
Published: May 2024

Introduction
This study measured the effect of Problem-Based Learning (PBL) with Screen-Based Simulation (SBS) on undergraduate football tactical decision-making, tactical skills, and student engagement. The Screen-Based Simulation showed tactical scenarios in real games to learners, promoting the identification and analysis of tactical problems in learning. Problem-Based Learning enabled learners to get a deeper understanding of the tactical problems and discuss them effectively.

Materials and Methods
Two simulation tools were used in this study. The first one, ‘football match basic offensive and defensive tactical simulation experiment platform,’ is scaffolding in football tactics teaching. Students could use the simulation platform to find tactical problems and learn tactics. The second one, TacticUP, is a screen-based simulation tool to test football tactical decision-making. We used second-year students majoring in physical education at a Chinese university. Seventy-nine students were divided into an experimental group using PBL-SBS and a group taught traditionally. Before the experiment, the tactical decision-making of both groups was assessed in a pretest, and at the end of the six-week experiment, the students were tested again. They also completed a questionnaire on tactical skills and student engagement.

Results
There was no significant difference between the pretest scores on tactical decision-making between the two groups (independent-sample t-test, sig = 0.997 > 0.05). However, after the experiment, significantly better improvement was observed in tactical decision-making in the experimental group. The pretest mean score (59) was significantly lower than the post-test one (67) on a scale of 100 (paired sample t-test, sig <0.01). ANOVA showed that the experimental group performed better in all aspects, namely tactical decision-making, tactical skill, and student engagement, than the traditional group (Sig values were all less than 0.01).

Conclusion
Compared with traditional teaching, PPL-SBS students performed better in tactical decision-making, tactical skills, and student engagement than students in the traditional teaching group.
Perceptions of Wearable Health Tools Post the COVID-19 Emergency in Low-Income Latin Communities: Qualitative Study
Authors: Cruz Stefany , Lu Claire , Ulloa Mara , Redding Alexander , Hester Josiah , Jacobs Maia 
Published: May 2024

Background
Mobile health (mHealth) wearable devices are increasingly being adopted by individuals to help manage and monitor physiological signals. However, the current state of wearables does not consider the needs of racially minoritized low–socioeconomic status (SES) communities regarding usability, accessibility, and price. This is a critical issue that necessitates immediate attention and resolution.

Objective
This study’s aims were 3-fold, to (1) understand how members of minoritized low-SES communities perceive current mHealth wearable devices, (2) identify the barriers and facilitators toward adoption, and (3) articulate design requirements for future wearable devices to enable equitable access for these communities.

Methods
We performed semistructured interviews with low-SES Hispanic or Latine adults (N=19) from 2 metropolitan cities in the Midwest and West Coast of the United States. Participants were asked questions about how they perceive wearables, what are the current benefits and barriers toward use, and what features they would like to see in future wearable devices. Common themes were identified and analyzed through an exploratory qualitative approach.

Results
Through qualitative analysis, we identified 4 main themes. Participants’ perceptions of wearable devices were strongly influenced by their COVID-19 experiences. Hence, the first theme was related to the impact of COVID-19 on the community, and how this resulted in a significant increase in interest in wearables. The second theme highlights the challenges faced in obtaining adequate health resources and how this further motivated participants’ interest in health wearables. The third theme focuses on a general distrust in health care infrastructure and systems and how these challenges are motivating a need for wearables. Lastly, participants emphasized the pressing need for community-driven design of wearable technologies.

Conclusions
The findings from this study reveal that participants from underserved communities are showing emerging interest in using health wearables due to the COVID-19 pandemic and health care access issues. Yet, the needs of these individuals have been excluded from the design and development of current devices.
Technological Aspects of Bridging the Gap Between Cell-Based Food and Conventional Meat
Authors: Kim Minsu , Jung Hyun Young , Ellies-Oury Marie-Pierre , Chriki Sghaier , Hocquette Jean-François , Jo Cheorun 
Published: May 2024

Cell-based food, including cultured meat, introduces an innovative complement to our dietary options, introducing cellular agriculture and tissue engineering on the meat market together with traditional livestock farming. Originating from medical tissue cultivation techniques, this approach is now tailored for food production, prioritizing cost-effectiveness, palatability, and resource efficiency. As technology strives to efficiently upscale production, consumer acceptance stands as a key factor in adopting this new protein source. This review explores advances in cultivating muscle and fat tissues in vitro, emphasizing the importance of achieving muscle maturity, innovating scaffolds, and optimizing media composition to closely replicate the qualities of meat. It also addresses quality assessments of cultured meat based on its texture, nutritional content, and flavor. A concise examination of consumer perceptions reveals that acceptance is influenced by a blend of cultural, psychological, and social factors, balancing the positive potential outlook on cultured meat’s benefits for society, the environment, and animal welfare against concerns about its unnaturalness, uncertainty, and safety. Demographic trends suggest higher acceptance among younger, well-educated and urban individuals, contrasting with reservations from those more familiar with the traditional meat sector. Addressing these varied viewpoints is essential for a better understanding of public acceptance if cultured meat is effectively introduced into our future food systems. As media interest in this alternative is still high, aligning technological developments with consumer expectations is crucial for the potential market introduction of cultured meat.
Design of A Semi-Automatic Banana Chips Slicing Machine to Reduce Musculoskeletal Disorders (MSDS) In Workers
Authors: Aprillova Carmelita Virry Clarissa , Ekoanindyo Firman Ardiansyah 
Published: May 2024

This research aims to improve the banana chip-slicing process at Aneka Keripik Clarissa'N UMKM. The slicing is done manually, leading to workers' discomfort and Musculoskeletal Disorders (MSDs). To address this, we are designing a new machine based on the Nordic Body Map (NBM) questionnaire results. This machine, tailored using workers' anthropometric data, aims to be ergonomic, reducing fatigue and enhancing comfort and efficiency in the slicing process. The goal is simplifying and speeding up production while ensuring maximum worker well-being. Keywords: Anthropometrics, MSDS, Nordic Body Map, Tool Design
Optimizing New Product Development in The Hijab Industry: A House of Risk Analysis on Marketing and Design Process
Authors: Wijaya Muhammad Agusta , Handayani Dwi , Basuki Demas Emirbuwono , Mukarim Rifki Nurul 
Published: May 2024

XYZ Company, a Micro, Small, and Medium Enterprise (MSME) based in Yogyakarta, specializes in producing hijabs but faces challenges in maintaining customer interest due to a misalignment between product designs and consumer preferences. To address this, the company actively engages in new product development (NPD), focusing on trend analysis and model innovation to cater to customer needs better. An essential part of minimizing risks during the NPD process involves evaluating and identifying potential pitfalls, particularly in marketing and design. This study employs the Hazard and Operability Review (HOR) method to assess risks systematically. Initial findings from HOR phase 1 reveal that inadequate competitor information (A3) leads to significant risks in competitor product identification (E3), contributing approximately 70.34% to the total Aggregate Risk Priority (ARP). Subsequently, in HOR phase 2, XYZ Company prioritizes ten mitigation actions, with conducting a comparative study of competitors' products (PA1) being the most critical, reflected by an ETDk value of 540. Keywords: House of Risk (HOR), Hijab Fashion, Hijab Industry, New Product Development (NPD)
Analysis Of Customer Satisfaction With Packaged Drinking Water Products Using Service Quality (SERVQUAL) And Importance Performance Analysis (IPA) Methods
Authors: Maulana Muhammad Helmi , Nuruddin Moch. 
Published: May 2024

PT. XYZ is a bottled mineral water manufacturer in Gresik, striving to deliver customer satisfaction and stay competitive. This study aims to quantify consumer satisfaction with PT. XYZ's product quality. We collected data through a questionnaire and analyzed it using the Servqual method and Importance Performance Analysis (IPA). The questionnaire included nine quality attributes, categorized into five dimensions. IPA was utilized to prioritize service quality attributes. The Servqual method revealed a negative gap, indicating suboptimal service. The Cartesian IPA diagram highlighted two critical areas for improvement: enhancing staff interaction during service and improving personnel demeanor, specifically their politeness, and friendliness. These improvements are vital as they align with consumer expectations and are essential for enhancing overall service quality at PT. XYZ. Keywords: Service Quality, Importance Performance Analysis (IPA), SERVQUAL
Quality Control Analysis of Painting Results in Steel Construction Projects Using Statistical Quality Control Methods and Failure Mode Effect Analysis at PT. BSB
Authors: Romadhoni Abrori , Dahdah Said Salim 
Published: May 2024

PT BSB is a company engaged in construction specialising in steel fabrication. There are various projects carried out at the company, namely bridges, steel structures, buildings, towers, and others. The research was conducted to analyse the quality of results in the painting process at PT BSB using statistical quality control (SQC) and failure mode effect analysis (FMEA) methods. Data collection is done by collecting primary and secondary data used in this study. The four types of painting defects obtained from the research results are Sagging/Runs, Orange Peel, Pin Hole and Seeds/Dirt. Based on the FMEA method, the level of defects can be determined based on the cumulative percentage value produced, where the highest defect value is 1750 Sagging/Runs defects. One of the factors causing the defect is the uneven spraying of paint, causing a layer of paint that is too thick, resulting in excessive accumulation of paint in certain parts that flow vertically and unevenly. From this research, it can be concluded that the company must use the SQC method to determine the causes of defects in the painting process and analyse improvements that must be prioritised. Keywords: Failure Mode Effect Analysis (FMEA), Painting Process Analysis, Statistical Quality Control (SQC)
Analysis Risk K3 Using JSA and HIRARC Methods Phosphoric Acid Factory on PT. Petrokimia Gresik
Authors: Rozikin Muhammad Khoiru , Hidayat Hidayat , Rizqi Akhmad Wasiur 
Published: May 2024

PT. Petrokimia Gresik is one of the industries that produce fertilisers, non-fertilizers, and other chemicals. PT. Petrokimia Gresik is divided into several departments, including the phosphoric acid factory. This research aims to identify and reduce potential hazards during the production process. This research uses (JSA) method to identify the hazard stage and (HIRARC) method to conduct risk analysis. Based on the risk hazard identification results, each job will be assessed based on severity and likelihood to establish the risk level. The research found that all extreme-risk jobs had 4 risks, high risks had 15 risks, medium risks had 2 risks, and no jobs with low-risk levels were found. The control plan carried out in this study is to control by elimination, engineering, administration, and personal protective equipment (PPE). Keywords: Occupational Health Safety, JSA, HIRARC.
Increasing Customer Satisfaction with Quality Function Deployment Methodology Based on Service Quality Analysis
Authors: Vazry Johan , Hidayat Hidayat , Negoro Pandu Yanuar 
Published: May 2024

One way to be superior to competing companies in the service field, especially customer satisfaction, is by analyzing service quality. Satisfied customers can increase their loyalty and have more trust in a company, so they can continue using its services. PT. XYZ is a company that offers logistics accommodation services; this research took the period from January 2023 to February 2024. It is known that the number of fluctuating customers tends to decrease. Apart from that, there were also several complaints submitted by customers, including products arriving late, inability to fulfill customer requests, delays in the delivery process, and top payments not being evenly distributed. This research used the Servqual and Quality Function Deployment (QFD) methodology. The Servqual method was carried out by distributing questionnaires to 95 respondents to identify the biggest gaps based on the dimensions of tangibles, reliability, assurance, empathy, and responsiveness, which was then carried out with a QFD analysis to determine the priority of corrective action. based on technical response. The research results show that the reliability dimension has the largest gap value, 0.21. A QFD analysis is carried out objectively to determine quality improvement based on technical responses obtained from customers' voices. In the QFD analysis, it is known that the priority corrective actions that must be taken are carrying out correct transaction recording, faster employee processes, increasing employee skills, increasing security, optimizing the system, and increasing availability. Keywords: Customer Expectations, Customers Satisfaction, House of Risk, Service Quality, Quality Function Deployment
IMPLEMENTASI PENGUATAN PERILAKU WIRAUSAHA SISWA MELALUI PROGRAM MARKET DAY DI SD NEGERI 3 ADIPASIR, BANJARNEGARA
Authors: Citra Mukti Restiana , Andriani Ana 
Published: May 2024

Education is an important place for the formation of student behavior and character. Market day is present as a form of implementation of entrepreneurial learning that supports aspects of student competence that are instilled through entrepreneurial values. This research was conducted at SD Negeri 3 Adipasir Rakit, Banjarnegara using a qualitative approach method aimed at describing the implementation of strengthening students' entrepreneurial behavior. The research results show that the market day program is a strong foundation for strengthening entrepreneurial behavior. The planning stage is the main foundation, where students are invited to formulate ideas, produce goods, set goals, and develop implementation strategies. Market day forms various entrepreneurial attitudes. Students demonstrate independence, creativity, leadership, honesty, curiosity, discipline, cooperation and innovation during activities. Market day is not only an ordinary school event, but also a forum for strengthening students' character and entrepreneurial skills.
Validation of a bupropion, dextromethorphan, and omeprazole cocktail for simultaneous phenotyping of cytochrome P450 2B11, 2D15, and 3A12 activities in dogs
Authors: Martinez Stephanie E. , Jimenez Tania E. Perez , Court Michael H. 
Published: May 2024

Abstract

OBJECTIVE
Develop a cytochrome P450 (CYP) phenotyping cocktail for dogs using specific substrates for hepatic P450 enzymes CYP2B11, CYP2D15, and CYP3A12 and determine whether alternative sampling methods (saliva and urine) or single time point samples could be used instead of multiple blood sampling.

ANIMALS
12 healthy client-owned dogs (8 females and 4 males) from February 2019 to May 2019.

METHODS
In a randomized crossover study, dogs received oral administration of the probe drug bupropion (75 mg), dextromethorphan (30 mg), or omeprazole (40 mg) alone or as a 3-drug combination (Program in Individualized Medicine [PrIMe] cocktail) to evaluate simultaneous phenotyping of CYP2B11, CYP2D15, and CYP3A12. Pharmacokinetic profiles for the probe drugs and metabolites were determined using plasma, saliva, and urine. Dogs received probe drugs alone or combined. Pharmacokinetic profiles up to 6 hours postdose for the probe drugs and metabolites were determined using plasma, saliva, and urine.

RESULTS
The PrIMe cocktail was well tolerated. There was no statistically significant interaction between the probe drugs when administered together. Single time point plasma metabolic ratios at 4 hours postdose for all probe drugs strongly correlated with the corresponding area under the plasma concentration-versus-time curve (AUC) ratios. Saliva AUC metabolic ratios for CYP3A12 and CYP2D15 and 6-hour urine for CYP2B11 and CYP2D15 were correlated with plasma AUC ratios.

CONCLUSIONS
The PrIMe cocktail can be used for simultaneous CYP phenotyping using plasma 4-hour single time point sample metabolic ratios. Saliva and urine sampling are suitable for specific CYPs.

CLINICAL RELEVANCE
The PrIMe cocktail has potential as a useful tool in dogs to detect clinically important CYP-mediated drug-drug interactions, identify novel pharmacogenes, determine the drug-metabolizing phenotype of individual dogs, aid in individualized dose selection, and evaluate the effects of various physiological states on drug metabolism.