bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding the Needs of Children Living with Parental Substance Misuse: Perspectives from Children and Practitioners
Authors: Todman Hannah , McLaughlin Hugh 
Published: May 2024

Abstract
The findings presented here are from a qualitative research study, adopting creative research methods with seven children to provide an in-depth understanding of their lived experience of living with Parental substance misuse (PSM). The children’s data were analysed using interpretive phenomenological analysis. The research also included focus groups with twenty-two professionals which added further understanding to the children’s experiences. Bronfenbrenner’s ecological theory was adopted as a framework to structure the research data from the micro to the macrosystem. Key messages identified the need for children living with PSM to be seen and heard and offered specialist support in their own right. The children experienced multiple risk factors, which were often enduring, and did not reduce as they grew older. This research provided an understanding of the complex needs of children and the risk factors which reach beyond their immediate home environment. This article argues for change, including improved training for front line practitioners, specialist service provision for children not reliant on their parents’ engagement, and for policy change and financial resources for their implementation. It is proposed that this would bridge the gap between research and practice and lead to improved outcomes for children living with PSM.
The ubiquitin ligase STUB1 suppresses tumorigenesis of renal cell carcinomas through regulating YTHDF1 stability
Authors: Ma Siquan , Sun Yi , Gao Guoyao , Zeng Jin , Chen Ke , Zhao Zhenyu 
Published: May 2024

Abstract
STIP1 homology and U-box protein 1 (STUB1), a crucial member of the RING family E3 ubiquitin ligase, serve dual roles as an oncogene and a tumor suppressor in various human cancers. However, the role and mechanism of STUB1 in clear cell renal cell carcinoma (ccRCC) remain poorly defined. Here, we identified YTHDF1 as a novel STUB1 interaction partner using affinity purification mass spectrometry. Furthermore, we revealed that STUB1 promotes the ubiquitination and degradation of YTHDF1. Consequently, STUB1 depletion leads to YTHDF1 upregulation in renal cancer cells. Functionally, STUB1 depletion promoted migration and invasion of ccRCC cells in a YTHDF1-dependent manner. Additionally, the depletion of STUB1 also increased the tumorigenic potential of ccRCC in a xenograft model. Importantly, STUB1 expression is downregulated in ccRCC tissues, and its low expression level correlates with advanced tumor stage and poor overall survival in ccRCC patients. Taken together, these findings reveal that STUB1 inhibits the tumorigenicity of ccRCC by regulating YTHDF1 stability.
Neural computations in prosopagnosia
Authors: Faghel-Soubeyrand Simon , Richoz Anne-Raphaelle , Waeber Delphine , Woodhams Jessica , Caldara Roberto , Gosselin Frédéric , Charest Ian 
Published: May 2024

Abstract
We report an investigation of the neural processes involved in the processing of faces and objects of brain-lesioned patient PS, a well-documented case of pure acquired prosopagnosia. We gathered a substantial dataset of high-density electrophysiological recordings from both PS and neurotypicals. Using representational similarity analysis, we produced time-resolved brain representations in a format that facilitates direct comparisons across time points, different individuals, and computational models. To understand how the lesions in PS’s ventral stream affect the temporal evolution of her brain representations, we computed the temporal generalization of her brain representations. We uncovered that PS’s early brain representations exhibit an unusual similarity to later representations, implying an excessive generalization of early visual patterns. To reveal the underlying computational deficits, we correlated PS’ brain representations with those of deep neural networks (DNN). We found that the computations underlying PS’ brain activity bore a closer resemblance to early layers of a visual DNN than those of controls. However, the brain representations in neurotypicals became more akin to those of the later layers of the model compared to PS. We confirmed PS’s deficits in high-level brain representations by demonstrating that her brain representations exhibited less similarity with those of a DNN of semantics.
Ten tips on how to care for your CKD patients in episodes of extreme heat
Authors: Khoshnaw Laveen J , Johnson Richard J , Young Sarah E 
Published: May 2024

ABSTRACT
Climate change is responsible for ≈75% of extreme heat events throughout the world. Heat events are associated with an increased risk for acute kidney injury, which contributes to the development of chronic kidney disease (CKD) and cardiovascular events. Patients with CKD are especially vulnerable to heat stress for a variety of reasons. A disproportionate percentage of patients with CKD live in poverty; experience homelessness, mental illness or disabilities; work outside or are elderly, all demographics that overlap with populations most susceptible to episodes of extreme heat. Therefore, it is reasonable to conclude that exposure to episodes of extreme heat can lead to the progression of CKD and increases morbidity and mortality. Given these concerns, clinicians must be prepared to promptly recognize complications of heat in CKD patients and to help patients appropriately acclimate. We propose the following tips for clinicians to effectively care for their CKD patients during extreme heat days.
Failing to Hash Into Supersingular Isogeny Graphs
Authors: Booher Jeremy , Bowden Ross , Doliskani Javad , Boris Fouotsa Tako , Galbraith Steven D , Kunzweiler Sabrina , Merz Simon-Philipp , Petit Christophe , Smith Benjamin , Stange Katherine E , Ti Yan Bo , Vincent Christelle , Voloch José Felipe , Weitkämper Charlotte , Zobernig Lukas 
Published: May 2024

Abstract
An important open problem in supersingular isogeny-based cryptography is to produce, without a trusted authority, concrete examples of ‘hard supersingular curves’ that is equations for supersingular curves for which computing the endomorphism ring is as difficult as it is for random supersingular curves. A related open problem is to produce a hash function to the vertices of the supersingular $\ell $-isogeny graph, which does not reveal the endomorphism ring, or a path to a curve of known endomorphism ring. Such a hash function would open up interesting cryptographic applications. In this paper, we document a number of (thus far) failed attempts to solve this problem, in the hope that we may spur further research, and shed light on the challenges and obstacles to this endeavour. The mathematical approaches contained in this article include: (i) iterative root-finding for the supersingular polynomial; (ii) gcd’s of specialized modular polynomials; (iii) using division polynomials to create small systems of equations; (iv) taking random walks in the isogeny graph of abelian surfaces, and applying Kummer surfaces and (v) using quantum random walks.
Coverless Image Steganography Using Content-Based Image Patch Retrieval
Authors: Taheri Fatemeh , Rahbar Kambiz 
Published: May 2024

Abstract
Image steganography is the process of concealing secret information within a cover image. The main challenge of steganography is to ensure that the embedding process does not significantly alter the cover file. In this paper, instead of modifying a cover image to carry information, steganography is performed using a set of images. These images are selected from a dataset of natural images. Each image in the dataset is divided into a number of non-overlapping patches. Then, indexing of the patches is performed based on their features. The secret image is also divided into a set of non-overlapping patches. Similar versions of the patches in the secret image are searched in the dataset to identify candidate patches. The final candidate is selected by calculating the minimum distance between the feature vector of the patches in the secret image and the patches in the dataset. Finally, the receiver retrieves the secret image using the pieces of selected images. Since, instead of embedding information in a cover image, a set of patches from natural images are selected without any changes, this approach can resist change-tracking tools, as demonstrated by experimental results, and also offers the advantage of high embedding capacity.
Home Visits in School Social Work Practice: History, Best Practices, and Future Considerations
Authors: Ochocki Stephanie , Stalnecker Deirdre , Paschall Lou 
Published: May 2024

Abstract
Beginning in 1906, the teachers who developed the profession of school social work conducted home visits to bridge communication between the school and home. In the more than 100 years that the profession has continued, home visiting has remained a cornerstone. Despite its continued importance, there remains a lack of comprehensive instruction on how to conduct effective home visits within higher education or professional development programs. This article aims to address this gap by acknowledging the limited research focused specifically on home visiting in school social work and consults the broader home visiting research, applying it to the unique setting of school social work. This article will delve into the purpose and benefits of home visiting, strategies for effective data collection during visits, cultural competencies necessary for fostering productive outcomes, and safety considerations for school social workers. Through this exploration, this article’s authors aim to provide valuable insights and guidance for school social workers striving to enhance their practice and strengthen connections between schools and families.
Lunar-linked biological rhythms in the immune system of freshwater three-spined stickleback
Authors: Jackson Joseph A , Stewart Alexander , Cable Joanne 
Published: May 2024

Abstract
Immune responses are widely accepted to be under circadian regulation via a molecular clock, with many practical consequences, but much less is known of how other biological rhythms could affect the immune system. In this study, we search for lunar rhythms (circalunar, circasemilunar, and circatidal cycles) in the immune expression of the recently marine-derived freshwater fish, the low-plate morph of the three-spined stickleback. We employed time series of immune expression (mRNA) measurements for 14 immune-associated genes, representing a variety of immunological pathways. Times series measurements were taken on fish populations in the wild, in seminatural outdoor mesocosms, and in the laboratory, according to sampling regimens originally designed to study circannual variation but with the additional potential to provide information about lunar variation. Our evidence best supported the existence of a very small endogenous tidal rhythm. This is consistent with previous suggestions of the existence of a primordial tidal endogenous clock, some elements of which may be conserved in animals evolving outside the marine environment.
Coexistence of variant-type transthyretin and immunoglobulin light-chain amyloidosis: a case report
Authors: Eda Yuko , Ishii Shunsuke , Onagi Suzuho , Katoh Nagaaki , Ako Junya 
Published: May 2024

Abstract

Background
Determining the type of amyloid deposits is clinically important for choosing the specific therapies for cardiac amyloidosis.

Case summary
A 78-year-old woman who had been experiencing fluid retention and dyspnoea on exertion for 6 months was referred to our hospital for the management of heart failure with left ventricular hypertrophy. Since 99mTc-hydroxymethylene diphosphonate scintigraphy showed mild cardiac uptake and significant elevation of serum free lambda chain (with a difference of 263 mg/L in free light chain), we suspected immunoglobulin light-chain amyloidosis (AL), and endomyocardial biopsy was performed. The deposit site within the myocardial tissue exhibited positive for Congo red staining and transthyretin immunostaining, however negative or non-specific for light-chain immunostaining including lambda and kappa staining. Genetic testing confirmed a mutation in V122I, variant-type transthyretin amyloidosis (ATTRv). Despite the administration of patisiran, her condition exhibited progressive deterioration. Additionally, she displayed macroglossia, an atypical manifestation in ATTRv amyloidosis. Further biopsies from tongue and abdominal wall fat culminated in a final diagnosis: the coexistence of ATTRv and AL (of the lambda type). Although treatment with melphalan and dexamethasone was started, she passed away 24 months after the initial visit. When the endomyocardial biopsy specimen underwent mass spectrometry as a post hoc analysis, both ATTR and AL amyloid were significantly detected.

Discussion
Coexistence of ATTRv and AL within cardiac amyloidosis is extremely uncommon. In situations where incongruities arise between the amyloid type determined via immunohistochemistry findings and the amyloid type assumed based on other clinical findings, mass spectrometry should be considered.
Using “Adopt a Bacterium” as an e-learning tool for simultaneously teaching microbiology to different health-related university courses
Authors: dos Santos Hadassa Cristhina de Azevedo Soares , Armellini Bárbara Rodrigues Cintra , Naves Giovanna Lello , Bueris Vanessa , Moreno Ana Carolina Ramos , Ferreira Rita de Cássia Café 
Published: May 2024

Abstract
The COVID-19 pandemic has posed challenges for education, particularly in undergraduate teaching. In this study, we report on the experience of how a private university successfully addressed this challenge through an active methodology applied to a microbiology discipline offered remotely to students from various health-related courses (veterinary, physiotherapy, nursing, biomedicine, and nutrition). Remote teaching was combined with the “Adopt a Bacterium” methodology, implemented for the first time on Google Sites. The distance learning activity notably improved student participation in microbiology discussions, both through word cloud analysis and the richness of discourse measured by the Shannon index. Furthermore, feedback from students about the e-learning approach was highly positive, indicating its effectiveness in motivating and involving students in the learning process. The results also demonstrate that despite being offered simultaneously to students, the methodology allowed for the acquisition of specialized knowledge within each course and sparked student interest in various aspects of microbiology. In conclusion, the remote “Adopt a Bacterium” methodology facilitated knowledge sharing among undergraduate students from different health-related courses and represented a valuable resource in distance microbiology education.
Multispecies bacterial invasion of human host cells
Authors: Abell-King Charlotte , Pokhrel Alaska , Rice Scott A , Duggin Iain G , Söderström Bill 
Published: May 2024

Abstract
Urinary tract infection (UTI), one of the most common bacterial infections worldwide, is a typical example of an infection that is often polymicrobial in nature. While the overall infection course is known on a macroscale, bacterial behavior is not fully understood at the cellular level and bacterial pathophysiology during multispecies infection is not well characterized. Here, using clinically relevant bacteria, human epithelial bladder cells and human urine, we establish co-infection models combined with high resolution imaging to compare single- and multi-species bladder cell invasion events in three common uropathogens: uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae and Enterococcus faecalis. While all three species invaded the bladder cells, under flow conditions the Gram-positive E. faecalis was significantly less invasive compared to the Gram-negative UPEC and K. pneumoniae. When introduced simultaneously during an infection experiment, all three bacterial species sometimes invaded the same bladder cell, at differing frequencies suggesting complex interactions between bacterial species and bladder cells. Inside host cells, we observed encasement of E. faecalis colonies specifically by UPEC. During subsequent dispersal from the host cells, only the Gram-negative bacteria underwent infection-related filamentation (IRF). Taken together, our data suggest that bacterial multispecies invasions of single bladder cells are frequent and support earlier studies showing intraspecies cooperation on a biochemical level during UTI.
What Frailty Can Tell Us About Successful Ageing: Towards a Different Paradigm for Ageing Well
Authors: Pickard Susan 
Published: May 2024

Abstract
This paper considers the concept of successful aging by means of a dialogue with the concept of frailty. This dialogue reveals the limits and blind spots of both concepts as well as their apparent dichotomy and the importance of understanding both the objective and subjective experience of aging. In particular, the dialogue highlights that both frailty and successful aging are social constructs that derive their meaning from what society values (autonomy, youthful capacities). They cannot by themselves account for the fact that flourishing and frailty are often found together whilst conversely successful aging may not bring satisfaction. I argue that the arts and humanities supply us with conceptual and methodological tools with which to revisit what it is to age well offering a holistic approach that combines sensitivity both to older people’s lived experience and to the underpinning material conditions and embodied realities. For this purpose, and building on previous scholarship in cultural gerontology, I suggest the unique value of concepts and frameworks associated by Simone de Beauvoir. When brought into alignment with the tenets of cultural and narrative gerontology, these concepts facilitate a rich understanding of the nuances and paradoxes of flourishing in deep old age which can also aid in restorying both old age and the life course more generally. I illustrate this through two examples: a feminist self-help guide to aging, which accepts both limitations and growth and a film that imagines the possibilities of authentic aging even despite a context of poverty, patriarchy, and Alzheimer’s disease.
Unleashing the potential of Health Promotion in primary care—a scoping literature review
Authors: Bisak Adela , Stafström Martin 
Published: May 2024

Abstract
The purpose of this study is to gain a better understanding of the role and extent of health promotion lifestyle interventions targeting adults in primary care, and especially those who are considered overall healthy, i.e. to study the outcomes of research applying salutogenesis. We performed a literature review, with three specific aims. First, to identify studies that have targeted the healthy population in intervention within the primary health care field with health promotion activities. Second, to describe these interventions in terms of which health problems they have targeted and what the interventions have entailed. Third, to assess what these programs have resulted in, in terms of health outcomes. This scoping review of 42 studies, that applied salutogenesis in primary care interventions shows that health promotion targeting healthy individuals is relevant and effective. The PRISMA-ScR guidelines for reporting on scoping review were used. Most interventions were successful in reducing disease-related risks including CVD, CVD mortality, all-cause mortality, but even more importantly success in behavioural change, sustained at follow-up. Additionally, this review shows that health promotion lifestyle interventions can improve mental health, even when having different aims.
Fertility preservation before cancer treatment: the dilemma of saying ‘no’ as the price of glory
Authors: Grynberg Michaël , Sermondade Nathalie 
Published: May 2024

Abstract
A great deal of work has been carried out by professionals in reproductive medicine in order to raise awareness about fertility preservation (FP) techniques, particularly for women, and to ensure that FP is included in the care of young adults treated for cancer or a pathology requiring gonadotoxic treatment. If the importance of the development of our discipline is obvious, our militancy in favour of FP and our emotional projections must not make us forget that medical thinking must be carried out not only on a case-by-case basis, weighing up the benefit-risk balance, but also without losing sight that conceiving a child with one’s own gametes is not a vital issue. The cultural importance given to the genetic link with offspring may bias patients’ and physicians’ decisions, while other ways of achieving parenthood exist, and are often more effective. Systematic information should be provided on the existence of FP techniques, but this should not lead to their systematic implementation, nor should it obscure that early information will also allow patients to begin projecting themselves in alternative options to become parents.
Modeling Population Growth under Climate Stressors Using Age-Structured Matrix Models
Authors: Wada Haruka , Choi Wonil , Coutts Victoria M , Hoffman Alexander J , Steury Todd D 
Published: May 2024

Synopsis
Climate resilience, a focus of many recent studies, has been examined from ecological, physiological, and evolutionary perspectives. However, sampling biases toward adults, males, and certain species have made establishing the link between environmental change and population-level change problematic. Here, we used data from four laboratory studies, in which we administered pre- and postnatal stressors, such as suboptimal incubation temperature, heat stress, and food restriction, to zebra finches. We then quantified hatching success, posthatch survival, and reproductive success, to parameterize age-structured population dynamics models with the goal of estimating the effect of the stressors on relative population growth rates. Using the same model structure, we tested the hypothesis that early life stages influence population growth rate more than later life stages. Our models suggested that stressful events during embryonic development, such as suboptimal incubation temperatures and reduced gas exchange for the embryos, have a greater total impact on population growth than posthatch stressors, such as heat stress and food restriction. However, among life history traits, differences in hatching success and sex ratio of offspring in response to stressors changed population growth rates more than differences in any other demographic rate estimates. These results suggest that when predicting population resilience against climate change, it is critical to account for effects of climate change on all life stages, including early stages of life, and to incorporate individuals’ physiology and stress tolerance that likely influence future stress responses, reproduction, and survival.