bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autonomous quantum heat engine based on non-Markovian dynamics of an optomechanical Hamiltonian
Authors: Rasola Miika , Möttönen Mikko 
Published: April 2024

AbstractWe propose a recipe for demonstrating an autonomous quantum heat engine where the working fluid consists of a harmonic oscillator, the frequency of which is tuned by a driving mode. The working fluid is coupled two heat reservoirs each exhibiting a peaked power spectrum, a hot reservoir peaked at a higher frequency than the cold reservoir. Provided that the driving mode is initialized in a coherent state with a high enough amplitude and the parameters of the utilized optomechanical Hamiltonian and the reservoirs are appropriate, the driving mode induces an approximate Otto cycle for the working fluid and consequently its oscillation amplitude begins to increase in time. We build both an analytical and a non-Markovian quasiclassical model for this quantum heat engine and show that reasonably powerful coherent fields can be generated as the output of the quantum heat engine. This general theoretical proposal heralds the in-depth studies of quantum heat engines in the non-Markovian regime. Further, it paves the way for specific physical realizations, such as those in optomechanical systems, and for the subsequent experimental realization of an autonomous quantum heat engine.
Characterization and identification of sources of rust resistance in Triticum militinae derivatives
Authors: Chowdhury Saikat , Bansal Shreshtha , Jha Shailendra K. , Saharan M. S. , M. Niranjana , K. Raghunandan , Choudhary Manish K. , Agarwal Priyanka , Mallick Niharika , Vinod  
Published: April 2024

AbstractTriticum militinae (2n = 4X = 28, AtAtGG), belonging to the secondary gene pool of wheat, is known to carry resistance to many diseases. Though some disease resistance genes were reported from T. timopheevii, the closest wild relative of T. militinae, there are no reports from T. militinae. Twenty-one T. militinae Derivatives (TMD lines) developed at the Division of Genetics, IARI, New Delhi, were evaluated for leaf and stripe rusts at seedling and adult plant stages. Eight TMD lines (6–4, 6–5, 11–6, 12–4, 12–8, 12–12, 13–7 and 13–9) showed seedling resistance to both leaf and stripe rusts while six TMD lines (7–5, 7–6, 11–5, 13–1, 13–3 and 13–4) showed seedling resistance to leaf rust but adult plant resistance to stripe rust and three TMD lines (9–1, 9–2 and 15) showed seedling resistance to leaf rust but susceptibility to stripe rust. Three TMD lines (2–7, 2–8 and 6–1) with adult plant resistance to leaf and stripe rusts were found to carry the known gene Lr34/Yr18. Ten TMD lines (7–5, 7–6, 9–1, 9–2, 11–5, 11–6, 12–12, 12–4, 12–8, and 15) with seedling resistance to leaf rust, showing absence of known genes Lr18 and Lr50 with linked markers requires further confirmation by the test of allelism studies. As not a single stripe rust resistance gene has been reported from T. militinae or its close relative T. timpopheevii, all the 8 TMD lines (6–4, 6–5, 11–6,12–4, 12–8, 12–12, 13–7 and 13–9) identified of carrying seedling resistance to stripe rust and 3 TMD lines (13–1, 13–3 and 13–4) identified of carrying adult plant resistance to stripe rust are expected to carry unknown genes. Also, all the TMD lines were found to be cytologically stable and thus can be used in inheritance and mapping studies.
The other-race effect of pupil contagion in infancy
Authors: Tsuji Yuki , Kanazawa So , Yamaguchi Masami K. 
Published: April 2024

AbstractPupil contagion refers to the observer’s pupil-diameter changes in response to changes in the pupil diameter of others. Recent studies on the other-race effect on pupil contagion have mainly focused on using eye region images as stimuli, revealing the effect in adults but not in infants. To address this research gap, the current study used whole-face images as stimuli to assess the pupil-diameter response of 5–6-month-old and 7–8-month-old infants to changes in the pupil-diameter of both upright and inverted unfamiliar-race faces. The study initially hypothesized that there would be no pupil contagion in either upright or inverted unfamiliar-race faces, based on our previous finding of pupil contagion occurring only in familiar-race faces among 5–6-month-old infants. Notably, the current results indicated that 5–6-month-old infants exhibited pupil contagion in both upright and inverted unfamiliar-race faces, while 7–8-month-old infants showed this effect only in upright unfamiliar-race faces. These results demonstrate that the face inversion effect of pupil contagion does not occur in 5–6-month-old infants, thereby suggesting the presence of the other-race effect in pupil contagion among this age group. Overall, this study provides the first evidence of the other-race effect on infants’ pupil contagion using face stimuli.
MRI radiomics in head and neck cancer from reproducibility to combined approaches
Authors: Corti Anna , Cavalieri Stefano , Calareso Giuseppina , Mattavelli Davide , Ravanelli Marco , Poli Tito , Licitra Lisa , Corino Valentina D. A. , Mainardi Luca 
Published: April 2024

AbstractThe clinical applicability of radiomics in oncology depends on its transferability to real-world settings. However, the absence of standardized radiomics pipelines combined with methodological variability and insufficient reporting may hamper the reproducibility of radiomic analyses, impeding its translation to clinics. This study aimed to identify and replicate published, reproducible radiomic signatures based on magnetic resonance imaging (MRI), for prognosis of overall survival in head and neck squamous cell carcinoma (HNSCC) patients. Seven signatures were identified and reproduced on 58 HNSCC patients from the DB2Decide Project. The analysis focused on: assessing the signatures’ reproducibility and replicating them by addressing the insufficient reporting; evaluating their relationship and performances; and proposing a cluster-based approach to combine radiomic signatures, enhancing the prognostic performance. The analysis revealed key insights: (1) despite the signatures were based on different features, high correlations among signatures and features suggested consistency in the description of lesion properties; (2) although the uncertainties in reproducing the signatures, they exhibited a moderate prognostic capability on an external dataset; (3) clustering approaches improved prognostic performance compared to individual signatures. Thus, transparent methodology not only facilitates replication on external datasets but also advances the field, refining prognostic models for potential personalized medicine applications.
Intrarenal pressure detection during flexible ureteroscopy with fiber optic pressure sensor system in porcine model
Authors: Bai Junjie , Chi Yangjian , Shangguan Tong , Lin Jun , Ye Yushi , Huang Jianfeng , Wen Yahui , Liu Rong , Chen Ru , Cai Weizhong , Chen Jianhui 
Published: April 2024

AbstractTo validate the feasibility of a fiber-optic pressure sensor-based pressure measurement device for monitoring intrarenal pressure and to analyze the effects of ureteral acess sheath (UAS) type, surgical location, perfusion flow rate, and measurement location on intrarenal pressure (IRP). The measurement deviations and response times to transient pressure changes were compared between a fiber-optic pressure sensing device and a urodynamic device IRP in an in vitro porcine kidney and in a water tank. Finally, pressure measurements were performed in anesthetized female pigs using fiber-optic pressure sensing device with different UAS, different perfusion flow rates, and different surgical positions at different renal calyces and ureteropelvic junctions (UPJ). According to our operation, the result is fiber optic pressure sensing devices are highly accurate and sensitive. Under the same conditions, IRP varied among different renal calyces and UPJ (P < 0.05). IRP was lowest at 50 ml/min and highest at 150 ml/min (P < 0.05). Surgical position had a significant effect on IRP (P < 0.05). 12/14 Fr UAS had a lower IRP than 11/13 Fr UAS. Therefore fiber optic pressure sensing devices are more advantageous for IRP measurements. In ureteroscopy, the type of ureteral sheath, the surgical position, the perfusion flow rate, and the location of the measurement all affect the intrarenal pressure value.
Protecting the non-operative lobe/s of the operative lung can reduce the pneumonia incidence after thoracoscopic lobectomy: a randomised controlled trial
Authors: Zhou Chao , Song Shan , Fu Jianfeng , Zhao Xuelian , Liu Huaqin , Pei Huanshuang , Zhang Shasha , Guo Hongbo , Cui Xinxin 
Published: April 2024

AbstractLung isolation usually refers to the isolation of the operative from the non-operative lung without isolating the non-operative lobe(s) of the operative lung. We aimed to evaluate whether protecting the non-operative lobe of the operative lung using a double-bronchial blocker (DBB) with continuous positive airway pressure (CPAP) could reduce the incidence of postoperative pneumonia. Eighty patients were randomly divided into two groups (n = 40 each): the DBB with CPAP (Group DBB) and routine bronchial blocker (Group BB) groups. In Group DBB, a 7-Fr BB was placed in the middle bronchus of the right lung for right lung surgery and in the inferior lobar bronchus of the left lung for left lung surgery. Further, a 9-Fr BB was placed in the main bronchus of the operative lung. In Group BB, routine BB placement was performed on the main bronchus on the surgical side. The primary endpoint was the postoperative pneumonia incidence. Compared with Group BB, Group DBB had a significantly lower postoperative pneumonia incidence in the operative (27.5% vs 5%, P = 0.013) and non-operative lung (40% vs 15%) on postoperative day 1. Compared with routine BB use for thoracoscopic lobectomy, using the DBB technique to isolate the operative lobe from the non-operative lobe(s) of the operative lung and providing CPAP to the non-operative lobe(s) through a BB can reduce the incidence of postoperative pneumonia in the operative and non-operative lungs.
Ribosomal S6 kinase 2-forkhead box protein O4 signaling pathway plays an essential role in melanogenesis
Authors: Jeung Dohyun , Lee Ga-Eun , Chen Weidong , Byun Jiin , Nam Soo-Bin , Park You-Min , Lee Hye Suk , Kang Han Chang , Lee Joo Young , Kim Kwang Dong , Hong Young-Soo , Lee Cheol-Jung , Kim Dae Joon , Cho Yong-Yeon 
Published: April 2024

AbstractAlthough previous studies have examined the signaling pathway involved in melanogenesis through which ultraviolet (UV) or α-melanocyte-stimulating hormones (α-MSH) stimuli act as key inducers to produce melanin at the stratum basal layer of the epidermis, the signaling pathway regulating melanogenesis is still controversial. This study reports that α-MSH, not UVA and UVB, acted as a major stimulus of melanogenesis in B16F10 melanoma cells. Signaling pathway analysis using gene knockdown technology and chemical inhibitors, the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)/p90 ribosomal S6 kinase 2 (RSK2) played an important role in melanogenesis. Unexpectedly, LY294002, a PI3K inhibitor, increased melanogenesis without UV or α-MSH stimulation, suggesting that the PI3K/AKT signaling pathway may not be a major signaling pathway for melanogenesis. Chemical inhibition of the MEKs/ERKs/RSK2 signaling pathway using U0126 or BI-D1870 suppressed melanogenesis by stimulation of UVA or α-MSH stimulation, or both. In particular, the genetic depletion of RSK2 or constitutive active (CA)-RSK2 overexpression showed that RSK2 plays a key role in melanogenesis. Interestingly, forkhead box protein O4 (FOXO4) was phosphorylated by RSK2, resulting in the increase of FOXO4’s transactivation activity. Notably, the FOXO4 mutant harboring serine-to-alanine replacement at the phosphorylation sites totally abrogated the transactivation activity and reduced melanin production, indicating that RSK2-mediated FOXO4 activity plays a key role in melanogenesis. Furthermore, kaempferol, a flavonoid inhibiting the RSK2 activity, suppressed melanogenesis. In addition, FOXO4-wt overexpression showed that FOXO4 enhance melanin synthesis. Overall, the RSK2-FOXO4 signaling pathway plays a key role in modulating melanogenesis.
Coordinated response of endemic gastropods to Late Glacial and Holocene climate-driven paleohydrological changes in a small thermal pond of Central Europe
Authors: Gulyás Sándor , Sümegi Pál 
Published: April 2024

AbstractThe thermal spring-fed Lake Pețea located in NW Romania southeast of the city of Oradea harbors a unique endemic warm water biota. It is the only location in Europe where thermal water endemic melanopsid Microcolpia parreyssii (Philippi, 1847) lived along with the highly endangered warm-water relict neritid Theodoxus prevostianus. Lake Petea’s evolution was mainly controlled by major climate-driven hydrological changes also seen in regional records. The hydrological changes were mainly controlled by varying input of thermal water due to recurring increased/decreased recharge of the underground karst water system. The driving factor was warming connected to the interstadial GI 1 increasing recharge by melting of regional ice sheets in the Late Glacial. Conversely, during the Younger Dryas (H0) and the Holocene increasing/decreasing moisture availability was in control. Low stands created multiple bottlenecks reducing genetic variability seen in the appearance of extreme morphologies during next rapid climate melioration. The studied gastropods responded mostly similarly to changes controlling the availability of elements in shell construction and habitat reduction leading to changes in shape, density, size. Periods of lower lake levels and reduced warm water input are characterized by the emergence of elongated tightly coiled shells while globular, compressed loosely coiled shells develop at times of warmer water provision and increased Mg availability. In size there is a contrasting trend. Namely globose Th. prevostianus shells are larger than the elongated ones. Conversely globose, compressed Microcolpia are generally smaller than their elongated spindle-shaped counterparts. In this sense the development of dwarf morphotypes in warmer water habitats is characteristic of Lake Pețea melanopsids. This type of dwarfism i.e. the reduction of shell size is lacking though in Lake Pețea neritids. Our findings also confirm the presence of various ecophenotypes of Microcolpia in the pond degrading our endemic species Mi. parreyssii to a variety of Mi. daudebartii.
Tuning the electronic properties and band offset of h-BN/diamond mixed-dimensional heterostructure by biaxial strain
Authors: Qu Yipu , Xu Hang , Hu Jiping , Wang Fang , Liu Yuhuai 
Published: April 2024

AbstractThe h-BN/diamond mix-dimensional heterostructure has broad application prospects in the fields of optoelectronic devices and power electronic devices. In this paper, the electronic properties and band offsets of hexagonal boron nitride (h-BN)/(H, O, F, OH)-diamond (111) heterostructures were studied by first-principles calculations under biaxial strain. The results show that different terminals could significantly affect the interface binding energy and charge transfer of h-BN/diamond heterostructure. All heterostructures exhibited semiconductor properties. The h-BN/(H, F)-diamond systems were indirect bandgap, while h-BN/(O, OH)-diamond systems were direct bandgap. In addition, the four systems all formed type-II heterostructures, among which h-BN/H-diamond had the largest band offset, indicating that the system was more conducive to the separation of electrons and holes. Under biaxial strain the bandgap values of the h-BN/H-diamond system decreased, and the band type occurred direct–indirect transition. The bandgap of h-BN/(O, F, OH)-diamond system increased linearly in whole range, and the band type only transformed under large strain. On the other hand, biaxial strain could significantly change the band offset of h-BN/diamond heterostructure and promote the application of this heterostructure in different fields. Our work provides theoretical guidance for the regulation of the electrical properties of h-BN/diamond heterostructures by biaxial strain.
C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
Authors: Winkler Clayton W. , Evans Alyssa B. , Carmody Aaron B. , Lack Justin B. , Woods Tyson A. , Peterson Karin E. 
Published: April 2024

AbstractInflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2 deficiency substantially reduces iMO recruitment for most, but not all encephalitic viruses. Here we show CCR7 acts synergistically with CCR2 to control this process. Following Herpes simplex virus type-1 (HSV-1), or La Crosse virus (LACV) infection, we find iMO proportions are reduced by approximately half in either Ccr2 or Ccr7 knockout mice compared to control mice. However, Ccr2/Ccr7 double knockouts eliminate iMO recruitment following infection with either virus, indicating these receptors together control iMO recruitment. We also find that LACV induces a more robust iMO recruitment than HSV-1. However, unlike iMOs in HSV-1 infection, LACV-recruited iMOs do not influence neurological disease development. LACV-induced iMOs have higher expression of proinflammatory and proapoptotic but reduced mitotic, phagocytic and phagolysosomal transcripts compared to HSV-1-induced iMOs. Thus, virus-specific activation of iMOs affects their recruitment, activation, and function.
Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogs
Authors: Ammons Dylan T. , Hopkins Leone S. , Cronise Kathryn E. , Kurihara Jade , Regan Daniel P. , Dow Steven 
Published: April 2024

AbstractOsteosarcoma (OS) is a heterogeneous, aggressive malignancy of the bone that disproportionally affects children and adolescents. Therapeutic interventions for OS are limited, which is in part due to the complex tumor microenvironment (TME). As such, we used single-cell RNA sequencing (scRNA-seq) to describe the cellular and molecular composition of the TME in 6 treatment-naïve dogs with spontaneously occurring primary OS. Through analysis of 35,310 cells, we identified 41 transcriptomically distinct cell types including the characterization of follicular helper T cells, mature regulatory dendritic cells (mregDCs), and 8 tumor-associated macrophage (TAM) populations. Cell-cell interaction analysis predicted that mregDCs and TAMs play key roles in modulating T cell mediated immunity. Furthermore, we completed cross-species cell type gene signature homology analysis and found a high degree of similarity between human and canine OS. The data presented here act as a roadmap of canine OS which can be applied to advance translational immuno-oncology research.
Intra-urban house prices in Madrid following the financial crisis: an exploration of spatial inequality
Authors: Kenyon Gladys Elizabeth , Arribas-Bel Dani , Robinson Caitlin , Gkountouna Olga , Arbués Pelayo , Rey-Blanco David 
Published: April 2024

AbstractIn this paper we explore the temporal dynamics of spatial inequality in housing prices for Madrid, the capital city of Spain. Spatial inequalities are a concerning feature of urban areas across the globe. It has been suggested that within cities housing prices are becoming more geographically unequal over time, particularly since the 2008 housing market crash. However, more evidence is needed at the intra-urban level to understand neighbourhood house price differences in large urban areas. Changes are analysed during a key period of the housing market bust (2010–2015) and boom (2016–2019), using data from a major housing listing portal. Fine grain space-time analysis of the distribution of housing prices supports an increase in spatial inequality and polarisation at the neighbourhood level. Two spatially differentiated housing sub-markets of high- and low-priced housing are identified. The persistence and growth of spatial house price inequality has important societal implications for the wealth gap and segregation of rich and poor in cities.
Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer
Authors: Gambelli Alice , Nespolo Anna , Rampioni Vinciguerra Gian Luca , Pivetta Eliana , Pellarin Ilenia , Nicoloso Milena S , Scapin Chiara , Stefenatti Linda , Segatto Ilenia , Favero Andrea , D’Andrea Sara , Mucignat Maria Teresa , Bartoletti Michele , Lucia Emilio , Schiappacassi Monica , Spessotto Paola , Canzonieri Vincenzo , Giorda Giorgio , Puglisi Fabio , Vecchione Andrea , Belletti Barbara , Sonego Maura , Baldassarre Gustavo 
Published: April 2024

AbstractPlatinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic disease, disseminating in the abdomen and pelvis. Very few options are available for PT-resistant EOC patients, and little is known about how the acquisition of PT-resistance mediates the increased spreading capabilities of EOC. Here, using isogenic PT-resistant cells, genetic and pharmacological approaches, and patient-derived models, we report that Integrin α6 (ITGA6) is overexpressed by PT-resistant cells and is necessary to sustain EOC metastatic ability and adhesion-dependent PT-resistance. Using in vitro approaches, we showed that PT induces a positive loop that, by stimulating ITGA6 transcription and secretion, contributes to the formation of a pre-metastatic niche enabling EOC cells to disseminate. At molecular level, ITGA6 engagement regulates the production and availability of insulin-like growth factors (IGFs), over-stimulating the IGF1R pathway and upregulating Snail expression. In vitro data were recapitulated using in vivo models in which the targeting of ITGA6 prevents PT-resistant EOC dissemination and improves PT-activity, supporting ITGA6 as a promising druggable target for EOC patients.
Therapie einer Jugendlichen mit M. Osgood-Schlatter nach dem Strickland
Protokoll
Authors: Worni Angela 
Published: April 2024

ZusammenfassungAnna ist ein sportlich aktives Mädchen. Doch seit geraumer Zeit klagt sie über Kniebeschwerden, die immer
schlimmer werden. Sie hat keinen Spaß mehr am Sporttreiben. Physiotherapeutin Angela Worni erklärt in
ihrem Fallbeispiel, wie die optimale Therapie bei M. Osgood-Schlatter aussieht – und auf welche
Schwierigkeiten sie bei der Umsetzung gestoßen ist.