bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bias‐Dependent Weight Update Characteristics of Low Power Synaptic Pass‐Transistors with a Hf‐Doped ZnO Channel Layer
Authors: Cha Danyoung , Pi Jeongseok , Do Gyoungyeop , Lee Nayeong , Tae Kunhee , Lee Sungsik 
Published: June 2024

AbstractA study on a bias voltage‐dependent weight update characteristics in a sub‐threshold region of a low power synaptic pass‐transistor (SPT) is presented with a Hf‐doped zinc oxide active layer. The SPT is a synaptic thin‐film transistor (TFT) in series with a load TFT which is used as a resistive load (RL) to be scaled by a bias voltage (VB). Here, when theVBof the load TFT is modulated, theRLcan be changed. With the changedRL, it is expected that the weight update characteristics (i.e., dynamic ratio) and electrical characteristics (i.e., power consumption) of the SPT are varied, respectively, suggesting a trade‐off relation between the dynamic ratio and power consumption. To check these, the pulsed characteristics of the fabricated SPT is monitored for differentVB, respectively. From experimental results, as increasingVB, it is found that the decreasedRLleads to the increase of the power consumption while enhancing the dynamic ratio because a full depression (FD) can be relatively easy. On the other hand, when theVBis reduced, theRLis increased resulting in the decrease of both the power dissipation and the dynamic ratio due to a difficulty of FD.
Interfacial Engineering by Self‐Assembled Monolayer for High‐Performance Sb2S3 Solar Cells
Authors: Chen Xueling , Zhao Yuqi , Li Chuang , Wang Xiaomin , Xiao Peng , Gong Junbo , Chen Tao , Xiao Xudong , Li Jianmin 
Published: June 2024

AbstractAntimony chalcogenides films and devices have drawn much attention in recent years because of their notable advantages. Unfortunately, the performance of Sb‐based solar cells is still underdeveloped compared to the theoretical value, which is closely related to charge carrier separation and transfer, highlighting the importance of enhancing the interface quality. In this work, an interfacial engineering by utilizing a self‐assembled monolayer (SAM) of MeO‐2PACz as an interface layer between the Sb2S3 and Spiro‐OMeTAD is developed to assist hole transport. The strong interface interaction between Sb2S3 and MeO‐2PACz is systematically investigated by Raman, X‐ray photoelectron spectroscopy (XPS) measurements, and Density functional theory (DFT) calculations. Through such interfacial engineering, a more uniform surface potential, bigger built‐in potential, better energy‐level match as well as outstanding photoelectric properties are achieved. Finally, the champion power conversion efficiency (PCE = 8.06%) of Sb2S3 solar cells with SAMs is inspiringly enhanced by >13%. It is expected that this effort will bring fresh insights and strategies for improving the performance of Sb‐based solar devices.
Spatiotemporal responsive hydrogel microspheres for the treatment of gastric cancer
Authors: Wang Li , Fan Lu , Filppula Anne M. , Wang Yu , Shang Luoran , Zhang Hongbo 
Published: June 2024

AbstractThe development of tumor drug microcarriers has attracted considerable interest due to their distinctive therapeutic performances. Current attempts tend to elaborate on the micro/nano‐structure design of the microcarriers to achieve multiple drug delivery and spatiotemporal responsive features. Here, the desired hydrogel microspheres are presented with spatiotemporal responsiveness for the treatment of gastric cancer. The microspheres are generated based on inverse opals, their skeleton is fabricated by biofriendly hyaluronic acid methacrylate (HAMA) and gelatin methacrylate (GelMA), and is then filled with a phase‐changing hydrogel composed of fish gelatin and agarose. Besides, the incorporated black phosphorus quantum dots (BPQDs) within the filling hydrogel endow the microspheres with outstanding photothermal responsiveness. Two antitumor drugs, sorafenib (SOR) and doxorubicin (DOX), are loaded in the skeleton and filling hydrogel, respectively. It is found that the drugs show different release profiles upon near‐infrared (NIR) irradiation, which exerts distinct performances in a controlled manner. Through both in vitro and in vivo experiments, it is demonstrated that such microspheres can significantly reduce tumor cell viability and enhance the efficiency in treating gastric cancer, indicating a promising stratagem in the field of drug delivery and tumor therapy.
Parenting practices and trajectories of proactive coping assets among emerging adult Black men
Authors: Collins Christopher C. , Kwon Elizabeth , Kogan Steven M. 
Published: June 2024

AbstractPositive youth development (PYD) frameworks suggest that a critical response to investigating the challenges young Black men living in resource poor communities experience involves identifying contextual resources in young men's lives and personal assets that promote success. The following study examines heterogeneity in proactive coping assets trajectories, parental practices as predictors of developmental trajectories, and associated outcomes of each trajectory. The study sample consisted of Black emerging adult men living in rural Georgia (N = 504). At baseline, men were between the ages of 19 and 22 (Mage = 20.29; SD = 1.10). At wave four, the participants' mean age was 27.67 (SD = 1.39). Results of growth mixture modeling from waves 1 to 3 discerned three developmental trajectory classes of emerging adults' proactive coping assets: a high and increasing class (n = 247, 49%), a low and stable class (n = 212, 42%), and a moderate and decreasing class (n = 45, 9%). Trajectory classes were linked to baseline levels of parental support, coaching, and expectations. Analysis revealed that parental support and parental coaching predicted proactive coping asset trajectory class identification. Links were then investigated between emerging adults' proactive coping asset trajectory classes and wave four physical health, depression, and alcohol use. Results revealed significant associations between class identification, alcohol use, and physical health. Study findings provide evidence supporting the impact of parenting on emerging adult Black men, underscoring the need to expand resources that support parenting and emerging adult relationships.
Healing and wellbeing outcomes of services for Aboriginal people based on cultural therapeutic ways: A systematic scoping review
Authors: Wise Sarah , Jones Amanda , Johnson Gabrielle , Croisdale Shantai , Callope Caley , Chamberlain Catherine 
Published: June 2024

AbstractAboriginal Australians experience disproportionately high rates of mental health problems as the result of European colonisation, and Western evidence‐based treatment has been strikingly ineffective in improving the situation. Cultural Therapeutic Ways is a culturally specific healing and wellbeing practice framework developed by the Victorian Aboriginal Child and Community Agency that focuses on culturally based practices, trauma awareness, and self‐determination. Despite wide recognition of the importance of these elements in Indigenous healing and wellbeing programs, its measurable empirical impact is currently unclear. This paper summarises findings from a systematic scoping review to ascertain the published knowledge base for Cultural Therapeutic Ways and the gaps in knowledge that can inform future evaluation. Forty‐two studies of programs that applied Cultural Therapeutic Ways with Indigenous participants from Australia, Canada, New Zealand, and the United States of America were identified from the literature search. Services based on Cultural Therapeutic Ways contributed to healing and wellbeing because they create safety, strengthen cultural connections, develop empowerment and provide opportunities to release emotion, and increase social and spiritual support. As the review set out to determine the published evidence base for Cultural Therapeutic Ways, other effective approaches may have been overlooked. To develop the evidence base for Cultural Therapeutic Ways, service design must clearly describe target groups, whether the program is delivered by Aboriginal people, the processes of Cultural Therapeutic Ways utilised in service delivery, and how they are blended with Western approaches. Research efforts could also productively be focused on identifying or constructing culturally appropriate outcome measures.
Anti‐CD19 chimeric antigen receptor T‐cell therapy in older patients with relapsed or refractory large B‐cell lymphoma: A multicenter study
Authors: Tun Aung M. , Patel Romil D. , St‐Pierre Frederique , Ouchveridze Evguenia , Niu Alex , Thordardottir Thorunn , Obasi Jennifer , Rosenthal Allison , Pophali Priyanka A. , Fenske Timothy S. , Karmali Reem , Ahmed Sairah , Johnston Patrick B. 
Published: June 2024

AbstractChimeric antigen receptor T‐cell (CAR‐T) therapy, despite being a potentially curative therapy in relapsed or refractory (RR) large B‐cell lymphoma (LBCL), remains underutilized in older patients due to limited clinical data. We therefore studied the safety and efficacy of CAR‐T therapy in older patients with RR LBCL in the real‐world setting. Patients aged ≥65 years with RR LBCL, treated with anti‐CD19 CAR‐T therapy at 7 US institutions were included in this multicenter, retrospective, observational study. In total, 226 patients were included. Median age at infusion was 71 years (range 65–89). Best objective and complete response rates were 86% and 62%, respectively. Median follow‐up after infusion was 18.3 months. The median progression‐free survival (PFS) was 6.9 months, with 6‐ and 12‐month PFS estimates of 54% and 44%, respectively. The nonrelapse mortality (NRM) rate was 10.9% at day 180, primarily due to infections, and not impacted by the age groups. Grade ≥3 cytokine release syndrome and neurotoxicity occurred in 7% and 26%, respectively. In univariate analysis, no significant difference in PFS was seen regardless of the age groups or CAR‐T type, whereas ECOG PS ≥2, elevated LDH, bulky disease, advanced stage, extranodal involvement, the need for bridging therapy, and prior bendamustine exposure were associated with shorter PFS. These findings support the use of CAR‐T in older patients, including those aged ≥80 years. The age at CAR‐T therapy did not influence safety, survival, and NRM outcomes. Older patients should not be excluded from receiving CAR‐T therapy solely based on their chronological age.
Workplace‐related determinants of mental health in food and bar workers in Western, high‐income countries: A systematic review
Authors: Grimmond Tessa , King Tania , LaMontagne Anthony D. , Oostermeijer Sanne , Harrap Benjamin , Newberry‐Dupé Jackson , Reavley Nicola 
Published: June 2024

AbstractBackgroundThis review synthesizes evidence from etiologic and intervention studies of workplace‐related determinants of mental health in workers in food and bar workers in the hospitality industry in Western high‐income countries.MethodsPeer‐reviewed literature published between January 2000 and August 2023 was gathered from five bibliographic databases. Any study design was eligible. Study quality was assessed using the Joanna Briggs Institute tools for appraisal.ResultsA narrative analysis was conducted for 26 included studies (total n = 15,069 participants) across Australia (3), Ireland (1), Norway (1), Spain (2), the United States (17) and the United Kingdom (2).Individual and task‐related factors such as high emotional job demands and low job control were associated with high burnout and depression. Uncivil and hostile interpersonal interactions with customers, management, and colleagues were found to contribute to poor mental health outcomes, including depression, anxiety, and burnout.ConclusionFindings from included studies highlight the impact of workplace culture, including management practices and workplace social support, on mental health. Organization‐level interventions may therefore be most effective for addressing individual, interpersonal, and organizational determinants of mental health in food and bar occupations, particularly when implemented as part of broader organizational efforts to support health and wellbeing. Industry‐wide policy changes may also be necessary to address structural concerns, including job and financial insecurity, job strain and access to benefits, such as secure sick leave and minimum contract hours.
Resting diffusing capacity and severity of radiographic disease predict gas exchange abnormalities with exercise in former US coal miners
Authors: Cohen Robert A. , Go Leonard H. T. , Friedman Lee , Zell‐Baran Lauren M. , Rose Cecile S. , Almberg Kirsten S. 
Published: June 2024

AbstractBackgroundThe US Department of Labor (DOL) does not fund diffusing capacity (DLCO) or metabolic measurements from cardiopulmonary exercise testing (CPET) for coal miners' disability evaluations. Although exercise arterial blood gas testing is covered, many miners are unable to perform maximal tests, and sampling at peak exercise can be challenging. We explored the relationship between resting DLCO, radiographic disease severity, and CPET abnormalities in former US coal miners.MethodsWe analyzed data from miners evaluated between 2005 and 2015. Multivariable linear and logistic regression analyses were used to examine relationships between percent predicted (pp) forced expiratory volume in 1 s (FEV1pp), DLCOpp, VO2maxpp, A‐a oxygen gradient (A‐a)pp, dead space fraction (Vd/Vt), disabling oxygen tension (PO2), and radiographic findings of pneumoconiosis.ResultsData from 2015 male coal miners was analyzed. Mean tenure was 28 years (SD 8.6). Thirty‐twopercent had an abnormal A‐a gradient (>150 pp), 20% had elevated Vd/Vt (>0.33), and 34% a VO2max < 60 pp. DLCOpp strongly predicted a disabling PO2, with an odds ratio (OR) of 2.33 [2.09−2.60], compared to 1.18 [1.08−1.29] for FEV1. Each increase in subcategory of small opacity (simple) pneumoconiosis increased the odds of a disabling PO2 by 42% [1.29−1.57], controlling for age, body mass index, pack‐years of tobacco smoke exposure, and years of coal mine employment.ConclusionsDLCO is the best resting pulmonary function test predictor of CPET abnormalities. Radiographic severity of pneumoconiosis was also associated with CPET abnormalities. These findings support funding DLCO testing for impairment and suggest the term “small opacity” should replace “simple” pneumoconiosis to reflect significant associations with impairment.
Regulating the Solvation Structure in Polymer Electrolytes for High‐Voltage Lithium Metal Batteries
Authors: Liu Yuncong , Jin Zhekai , Liu Zeyu , Xu Hao , Sun Furong , Zhang Xue‐Qiang , Chen Tao , Wang Chao 
Published: June 2024

AbstractSolid polymer electrolytes are promising electrolytes for safe and high‐energy‐density lithium metal batteries. However, traditional ether‐based polymer electrolytes are limited by their low lithium‐ion conductivity and narrow electrochemical window because of the well‐defined and intimated Li+‐oxygen binding topologies in the solvation structure. Herein, we proposed a new strategy to reduce the Li+‐polymer interaction and strengthen the anion‐polymer interaction by combining strong Li+‐O (ether) interactions, weak Li+‐O (ester) interactions with steric hindrance in polymer electrolytes. In this way, a polymer electrolyte with a high lithium ion transference number (0.80) and anion‐rich solvation structure is obtained. This polymer electrolyte possesses a wide electrochemical window (5.5 V versus Li/Li+) and compatibility with both Li metal anode and high‐voltage NCM cathode. Li||LiNi0.5Co0.2Mn0.3O2 full cells with middle‐high active material areal loading (~7.5 mg cm−2) can stably cycle at 4.5 V. This work provides new insight into the design of polymer electrolytes for high‐energy‐density lithium metal batteries through the regulation of ion‐dipole interactions.
Chromium Catalyzed Asymmetric Reformatsky Reaction
Authors: Lv Yong‐Feng , Liu Gang , Shi Zhaoxin , Wang Zhaobin 
Published: June 2024

AbstractThis study describes an unprecedented chromium‐catalyzed asymmetric Reformatsky reaction, enabling the synthesis of chiral β‐hydroxy carbonyl compounds from α‐chlorinated or α‐brominated esters and amides. By employing a chiral chromium/diarylamine bis(oxazoline) catalyst, we achieved relatively broad functional group tolerance. Distinct from known reports, the protocol operates under both classical and photoredox conditions, facilitated by the in situ formation of a nucleophilic chiral chromium intermediate through a radical‐polar crossover mechanism. Preliminary mechanistic insights, supported by DFT calculations, identify the nucleophilic aldehyde addition as the key stereo‐determining step. This approach not only overcomes the limitations of existing Reformatsky reactions but also provides a versatile strategy for accessing complex chiral molecules.
Mass Transfer Limitation within Molecular Crowding Electrolyte Reorienting (100) and (101) Texture for Dendrite‐Free Zinc Metal Batteries
Authors: Wang Ziqing , Wang Jiaao , Kawashima Kenta , Liu Zonghang , Henkelman Graeme , Mullins C. Buddie 
Published: June 2024

AbstractAqueous zinc metal batteries are emerging as a promising alternative for energy storage due to their high safety and low cost. However, their development is hindered by the formation of Zn dendrites and side reactions. Herein, a macromolecular crowding electrolyte (MCE40) is prepared by incorporating polyvinylpyrrolidone (PVP) into the aqueous solutions, exhibiting an enlarged electrochemical stability window and anti‐freezing properties. Notably, through electrochemical measurements and characterizations, it is discovered that the mass transfer limitation near the electrode surface within the MCE40 electrolyte inhibits the (002) facets. This leads to the crystallographic reorientation of Zn deposition to expose the (100) and (101) textures, which undergo a “nucleation‐merge‐growth” process to form a uniform and compact Zn deposition. Consequently, the MCE40 enables highly reversible and stable Zn plating/stripping in Zn/Cu half cells over 600 cycles and in Zn/Zn symmetric cells for over 3000 hours at 1.0 mA cm−2. Furthermore, Na0.33V2O5/Zn and α‐MnO2/Zn full cells display promising capacity and sustained stability over 500 cycles at room and sub‐zero temperatures. This study highlights a novel electrochemical mechanism for achieving preferential Zn deposition, introducing a unique strategy for fabricating dendrite‐free zinc metal batteries.
Tailoring d–p Orbital Hybridization to Decipher the Essential Effects of Heteroatom Substitution on Redox Kinetics
Authors: Zhao Jian , Zhang Yuxiao , Zhuang Zechao , Deng Yating , Gao Ge , Li Jiayi , Meng Alan , Li Guicun , Wang Lei , Li Zhenjiang , Wang Dingsheng 
Published: June 2024

AbstractThe heteroatom substitution is considered as a promising strategy for boosting the redox kinetics of transition metal compounds in hybrid supercapacitors (HSCs) although the dissimilar metal identification and essential mechanism that dominate the kinetics remain unclear. It is presented that d‐p orbital hybridization between the metal and electrolyte ions can be utilized as a descriptor for understanding the redox kinetics. Herein, a series of Co, Fe and Cu heteroatoms are respectively introduced into Ni3Se4 cathodes, among them, only the moderate Co‐substituted Ni3Se4 can hold the optimal d‐p orbital hybridization resulted from the formed more unoccupied antibonding states π*. It inevitably enhances the interfacial charge transfer and ensures the balanced OH− adsorption‐desorption to accelerate the redox kinetics validated by the lowest reaction barrier (0.59 eV, matching well with the theoretical calculations). Coupling with the lower OH− diffusion energy barrier, the prepared cathode delivers ultrahigh rate capability (~68.7 % capacity retention even the current density increases by 200 times), and an assembled HSC also presents high energy/power density. This work establishes the principles for determining heteroatoms and deciphers the underlying effects of the heteroatom substitution on improving redox kinetics and the rate performance of battery‐type electrodes from a novel perspective of orbital‐scale manipulation.
Unraveling the Origin of Multichannel Circularly Polarized Luminescence in a Pyrene‐Functionalized Topologically Chiral [2]Catenane
Authors: Wang Xueli , Wu Peicong , Wang Yu , Cui Tong , Jia Menghui , He Xiaoxiao , Wang Wei , Pan Haifeng , Sun Zhenrong , Yang Hai‐Bo , Chen Jinquan 
Published: June 2024

AbstractMechanically interlocked molecules (MIMs) are promising platforms for developing functionalized artificial molecular machines. The construction of chiral MIMs with appealing circularly polarized luminescence (CPL) properties has boosted their potential application in biomedicine and the optical industry. However, there is currently little knowledge about the CPL emission mechanism or the emission dynamics of these related MIMs. Herein, we demonstrate that time‐resolved circularly polarized luminescence (TRCPL) spectroscopy combined with transient absorption (TA) spectroscopy offers a feasible approach to elucidate the origins of CPL emission in pyrene‐functionalized topologically chiral [2]catenane as well as in a series of pyrene‐functionalized chiral molecules. For the first time, direct evidence differentiating the chiroptical signals originating from either topological (local state emission) or Euclidean chirality (excimer state emission) in these pyrene‐functionalized chiral molecules has been discovered. Our work not only establishes a novel and ideal approach to study CPL mechanism, but also provides a theoretical foundation for the rational design of novel chiral materials in the future.
Multi‐cell‐line learning for the data‐driven construction of mechanistic metabolic models
Authors: Lu Yen‐An , McCann Meghan G. , Hu Wei‐Shou , Zhang Qi 
Published: June 2024

AbstractMammalian cells are commonly used as hosts in cell culture for biologics production in the pharmaceutical industry. Structured mechanistic models of metabolism have been used to capture complex cellular mechanisms that contribute to varying metabolic shifts in different cell lines. However, little research has focused on the impact of temporal changes in enzyme abundance and activity on the modeling of cell metabolism. In this work, we present a framework for constructing mechanistic models of metabolism that integrate growth‐signaling control of enzyme activity and transcript dynamics. The proposed approach is applied to build models for three Chinese hamster ovary (CHO) cell lines using fed‐batch culture data and time‐series transcript profiles. Leveraging information from the transcriptome data, we develop a parameter estimation approach based on multi‐cell‐line (MCL) learning, which combines data sets from different cell lines and trains the individual cell‐line models jointly to improve model accuracy. The computational results demonstrate the important role of growth signaling and transcript variability in metabolic models as well as the virtue of the MCL approach for constructing cell‐line models with a limited amount of data. The resulting models exhibit a high level of accuracy in predicting distinct metabolic behaviors in the different cell lines; these models can potentially be used to accelerate the process and cell‐line development for the biomanufacturing of new protein therapeutics.