bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multimodal Imaging in Mucolipidosis Type IV: Siblings With Novel Genetic Variant
Authors: Yangzes Sonam , Verma Anjali , Kaur Anupriya , Spalkit Stanzin , Kakkar Nandita , Gupta Amit 
Published: June 2024

Purpose:
Utilization of multimodal imaging techniques to diagnose cases of mucolipidosis type IV (ML-IV) and report a new genetic variant.

Methods:
This study is a case report.

Results:
Case 1 involves a 4-year-old boy with corneal haziness and global developmental delay who showed an increased reflectivity of the corneal epithelium on anterior segment optical coherence tomography (AS-OCT). In addition, neurologic evaluation was suggestive of ML-IV. Further genetics evaluation confirmed ML-IV. Histology of the button revealed a thickened epithelial basement membrane. Case 2, the younger sibling, showed a milder corneal haze with similar changes on AS-OCT prompting us to further evaluate for ML-IV by genetics (positive MCOLN1 gene mutation). Both instances highlighted varied ML-IV presentations, but a persistent feature was hyperreflective epithelium.

Conclusions:
Our study emphasizes AS-OCT's role in screening ML-IV and advocates the role of genetic counseling of affected parents. We present 2 South-Asian siblings with ML-IV with a new genetic variant, emphasizing the utility of detailed ophthalmic and neurologic assessments using multimodal imaging.
Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Children With Germ Cell Tumor After Chemotherapy
Authors: De Pasquale Maria Debora , D’Angelo Paolo , Crocoli Alessandro , Vallero Stefano G. , Bertolini Patrizia , Miele Evelina , Terenziani Monica 
Published: June 2024

Background/Aim:

18F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) is a diagnostic tool widely used in adult oncology and some pediatric oncological settings. There are no established recommendations for the use of this imaging modality in pediatric malignant germ cell tumors (mGCT), however. Our aim is to evaluate the role of 18F-FDG PET/CT in the restaging of mGCT after chemotherapy in children and adolescents.

Methods:
We retrospectively reviewed patients with mGCT treated in Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) centers who underwent 18F-FDG PET/CT between 2011 and 2021.

Results:
Seventeen patients (median age 13 y) were included in the study. In 14 patients, 18F-FDG PET/CT was performed at diagnosis; 12 showed pathologic uptake. The 2 18F-FDG PET/CT negative cases were histologically defined as yolk sac tumor (YST) and mixed (chorioncarcinoma, YST). Nine of the 12 patients who had pathologic 18F-FDG PET/CT at diagnosis repeated the examination after neoadjuvant chemotherapy, before, second look surgery. In 5 cases, no pathologic uptake was evident. Histology showed necrosis alone in 4 cases and necrosis and mature teratoma in 1. In 3 of the 6 cases with pathologic uptake (2 of 6 patients did not perform the examination at diagnosis), histology showed persistence of malignant component, whereas in the remaining 3 cases, necrosis and mature teratoma were present.

Conclusion:
In our review of a series of children with mGCT, 18F-FDG PET/CT after neoadjuvant chemotherapy showed 1 of 5 false negatives and was unable to discriminate between residual malignant component and mature teratoma.
177Lu-DOTATATE PRRT Safety and Organ-at-Risk Dosimetry in Patients With Gastroenteropancreatic Neuroendocrine Tumors
Authors: Mileva Magdalena , Van Bogaert Camille , Marin Gwennaëlle , Danieli Rachele , Artigas Carlos , Levillain Hugo , Ameye Lieveke , Taraji-Schiltz Loubna , Stathopoulos Konstantinos , Wimana Zéna , Hendlisz Alain , Flamen Patrick , Karfis Ioannis 
Published: June 2024

Purpose
The aim of this study was to assess the association among toxicity, dosimetry of organs-at-risk, and disease progression in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with 177Lu-DOTATATE.

Patients and Methods
Thirty-seven patients with GEP-NETs underwent 177Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) in a single-arm, prospective, phase 2 study, where patients were followed up with blood tests, isotopic glomerular filtration rate (iGFR), and imaging examinations (CT/MRI and PET) every 6 months until disease progression. Adverse events (AEs) graded per CTCAEv4.03 and occurring during treatment were collected and followed up until resolution. Dosimetry, including biologically effective doses (BEDs) to kidneys, BED to bone marrow, and absorbed dose (AD) to spleen, was performed after each PRRT cycle. Statistical analyses explored associations among dosimetry, toxicity, and patient progression free-survival.

Results
The most common AEs were anemia and lymphopenia (65%), followed by thrombocytopenia and fatigue (each 51%), alopecia (46%), and nausea (41%). The most common grade ≥3 AE was lymphopenia (43%). There was no grade ≥3 nephrotoxicity. The median iGFR % decrease was 11% (P < 0.001), at a median follow-up of 23 months. iGFR %decrease and renal BED did not correlate (Spearman ρ = −0.09). Similarly, no significant association was found between bone marrow BED or spleen AD and the grades of hematological toxicities. We observed no association between progression free-survival and either the decline of renal function or the occurrence of hematological toxicities during PRRT.

Conclusions
This study confirms the safety profile of 177Lu-DOTATATE PRRT in patients with GEP-NETs irrespective of the dosimetry of organs at risk. Kidney, bone marrow, and spleen dosimetry measures were not associated with renal or hematological toxicity.
Acute microtubule changes linked to DMD pathology are insufficient to impair contractile function or enhance contraction-induced injury in healthy muscle
Authors: Vanegas Camilo , Ursitti Jeanine , Kallenbach Jacob G. , Pinto Kaylie , Harriot Anicca , Coleman Andrew K. , Shi Guoli , Ward Christopher W. 
Published: June 2024

AbstractDuchenne muscular dystrophy (DMD) is marked by the genetic deficiency of the dystrophin protein in striated muscle whose consequence is a cascade of cellular changes that predispose the susceptibility to contraction injury central to DMD pathology. Recent evidence identified the proliferation of microtubules enriched in post-translationally modified tubulin as a consequence of dystrophins absence that increases the passive mechanics of the muscle fiber and the excess mechanotransduction elicited reactive oxygen species and calcium signals that promote contraction injury. Motivated by evidence that acutely normalizing the disease microtubule alterations reduced contraction injury in murine DMD muscle (mdx), here we sought the direct impact of these microtubule alterations independent of dystrophins absence and the multitude of other changes consequent to dystrophic disease. To this end we used acute pharmacologic (epithiolone-D, EpoD; 4 hours) or genetic (vashohibin-2 and small vasohibin binding protein overexpression via AAV9; 2 weeks) strategies to effectively model the proliferation of detyrosination enriched microtubules in themdxmuscle. Quantifyingin vivonerve evoked plantarflexor function we find no alteration in peak torque nor contraction kinetics in WT mice modeling these DMD relevant MT alterations. Quantifying the susceptibility to eccentric contraction injury we show EpoD treatment proffered a small but significant protection from contraction injury while VASH/SVBP had no discernable impact. We conclude that the disease dependent MT alterations act in concert with additional cellular changes to predispose contraction injury in DMD.
Self-healing, biocompatible bioinks from self-assembled peptide and alginate hybrid hydrogels
Authors: Field Emily H. , Ratcliffe Julian , Johnson Chad J. , Binger Katrina J. , Reynolds Nicholas P. 
Published: June 2024

1.AbstractThere is a pressing need for new biomaterials that are printable, stiff and highly biocompatible. This is primarily due to the inverse relationship between the printability and viscosity of hydrogels. Cell-laden, printable, rigid biomaterials are needed for replicating stiffer tissues such as cartilage in regenerative medicine, modelling the fibrosis of tissue and cancer microenvironments, as well as in non-cellular research fields such as biosensors. Here, we have designed a hybrid material compromised of self-assembled Fmoc-FF peptide assemblies dispersed throughout a sodium alginate matrix. The resultant hybrid bioink has a stiffness up to 10 times greater than sodium alginate alone but remains highly printable, even when laden with high concentrations of cells. In addition, the thixotropic self-assembled peptide assemblies gave the hybrid bioinks highly desirable self-healing capabilities. The choice of solvent used to initially dissolve the peptides made significant differences to both the physical properties and the biocompatibility of the bioinks, with the best performing able to support the growth of encapsulated macrophages over 5 days. Our developed hybrid materials allow the bioprinting of materials previously considered too stiff to extrude without causing shear induced cytotoxicity with applications in tissue engineering and biosensing.
Reproducibility of radiomic features of the brain on ultrahigh-resolution MRI at 7 Tesla: a comparison of different segmentation techniques
Authors: Klinger Julian H. , Leithner Doris , Woo Sungmin , Weber Michael , Vargas H. Alberto , Mayerhoefer Marius E. 
Published: June 2024

ABSTRACTObjectivesTo determine the impact of segmentation techniques on radiomic features extracted from ultrahigh-field (UHF) MRI of the brain.Materials and MethodsTwenty-one 7T MRI scans of the brain, including a 3D magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) T1-weighted sequence with an isotropic 0.63 mm³ voxel size, were analyzed. Radiomic features (histogram, texture, and shape; total n=101) from six brain regions -cerebral gray and white matter, basal ganglia, ventricles, cerebellum, and brainstem-were extracted from segmentation masks constructed with four different techniques: the iGT (reference standard), based on a custom pipeline that combined automatic segmentation tools and expert reader correction; the deep-learning algorithm Cerebrum-7T; the Freesurfer-v7 software suite; and the Nighres algorithm. Principal components (PCs) were calculated for histogram and texture features. To test the reproducibility of radiomic features, intraclass correlation coefficients (ICC) were used to compare Cerebrum-7, Freesurfer-v7, and Nighres to the iGT, respectively.ResultsFor histogram PCs, median ICCs for Cerebrum-7T, Freesurfer-v7, and Nighres were 0.99, 0.42, and 0.11 for the gray matter; 0.84, 0.25, and 0.43 for the basal ganglia; 0.89, 0.063, and 0.036 for the white matter; 0.84, 0.21, and 0.33 for the ventricles; 0.94, 0.64, and 0.93 for the cerebellum; and 0.78, 0.21, and 0.53 for the brainstem. For texture PCs, median ICCs for Cerebrum-7T, Freesurfer-v7, and Nighres were 0.95, 0.21, and 0.15 for the gray matter; 0.70, 0.36, and 0.023 for the basal ganglia; 0.91, 0.25, and 0.023 for the white matter; 0.80, 0.75, and 0.59 for the ventricles; 0.95, 0.43, and 0.86 for the cerebellum; and 0.72, 0.39, and 0.46 for the brainstem. For shape features, median ICCs for Cerebrum-7T, FreeSurfer-v7, and Nighres were 0.99, 0.91, and 0.36 for the gray matter; 0.89, 0.90, and 0.13 for the basal ganglia; 0.98, 0.91, and 0.027 for the white matter; 0.91, 0.91, and 0.36 for the ventricles; 0.80, 0.68, and 0.47 for the cerebellum; and 0.79, 0.17, and 0.15 for the brainstem.ConclusionsRadiomic features in UHF MRI of the brain show substantial variability depending on the segmentation algorithm. The deep learning algorithm Cerebrum-7T enabled the highest reproducibility. Dedicated software tools for UHF MRI may be needed to achieve more stable results.
Does CEA or EUA matter for major commodity markets? Fresh evidence from the analysis of information spillovers and portfolio diversification
Authors: Zhang Jiahao , Wei Yu 
Published: June 2024

PurposeThis study conducts a comparative analysis of the diversification effects of China's national carbon market (CEA) and the EU ETS Phase IV (EUA) within major commodity markets.Design/methodology/approachThe study employs the TVP-VAR extension of the spillover index framework to scrutinize the information spillovers among the energy, agriculture, metal, and carbon markets. Subsequently, the study explores practical applications of these findings, emphasizing how investors can harness insights from information spillovers to refine their investment strategies.FindingsFirst, the CEA provide ample opportunities for portfolio diversification between the energy, agriculture, and metal markets, a desirable feature that the EUA does not possess. Second, a portfolio comprising exclusively energy and carbon assets often exhibits the highest Sharpe ratio. Nevertheless, the inclusion of agricultural and metal commodities in a carbon-oriented portfolio may potentially compromise its performance. Finally, our results underscore the pronounced advantage of minimum spillover portfolios; particularly those that designed minimize net pairwise volatility spillover, in the context of China's national carbon market.Originality/valueThis study addresses the previously unexplored intersection of information spillovers and portfolio diversification in major commodity markets, with an emphasis on the role of CEA.
The puzzle of innovation and innovation strategies in Kenyan academic libraries
Authors: Otike Fredrick , Hajdu Barát Ágnes , Kiszl Péter 
Published: June 2024

Purpose
The advancement of technology has brought much uncertainty in the access and utilization of information resources in academic libraries. This research sought to determine the extent to which academic libraries in Kenya engage in innovation and use innovative strategies. In addition, this study aims to identify the specific innovation practices and strategies used by these libraries to ensure they effectively address users’ information needs and remain relevant within the Kenyan context.

Design/methodology/approach
This study adopted a qualitative research design. Data was collected using face-to-face interviews that targeted key personnel in the academic library system, including the university librarian, the circulation librarian and the digital/systems librarian. In total, 21 respondents were interviewed in this study. Additional data was gathered by examining primary documents such as academic library policies, university websites and library brochures, among other sources. The study used purposive sampling techniques to select the population sample and the theoretical saturation to determine the sample size.

Findings
The study revealed a pressing need for change in the academic library landscape in Kenya. It established that the concept of innovation and innovation strategies is still new in academic libraries in Kenya, and libraries are still confined to traditional and routine duties. There is a lack of appropriate strategies for enhancing innovation practices/strategies in academic libraries. The paper, therefore, strongly recommends the reorganization of academic libraries in Kenya.

Originality/value
To the best of the authors’ knowledge, this research is the first to analyze innovation strategies and practices in academic libraries in Kenya. This study sheds light on the puzzles facing most academic libraries in Kenya regarding innovation and innovation strategies. It introduces the importance of academic libraries to embrace innovation as a strategy to avoid disruptive innovation.
The role of omnichannel integration and digital value in building brand trust: a customer psychological perception perspective
Authors: Yang Zhihui , Hu Dongbin , Chen Xiaohong 
Published: June 2024

PurposeIn the dynamic landscape of the digital economy, companies are increasingly adopting omnichannel integration strategies to enhance customer experiences. However, the interplay between this strategy and digitalisation in fostering brand trust remains uncharted. Drawing on the social exchange and psychological reactance theories, this study ventures into unexplored territory by examining the impact of omnichannel integration and digital value on brand trust building. It also delves into the boundary roles of customers’ psychological perceptions, both positive (customer empowerment) and negative (privacy concerns and perceived deception), in this process.Design/methodology/approachThis study conducted an online survey of 595 omnichannel users in China and validated the model using partial least squares structural equation modelling (PLS-SEM).FindingsThis study’s results have significant implications for businesses. They show that customer perception of omnichannel integration and perceived digital value are critical drivers of omnichannel brand trust, with customer empowerment playing a mediating role. Notably, the study also reveals that customers’ negative psychological perceptions can have different moderating effects, highlighting the need for businesses to address these concerns in their omnichannel strategies.Originality/valueThis study breaks new ground in marketing research by highlighting the benefits of omnichannel integration and incorporating digital perspectives. It demonstrates the positive impact of blending customer perception of omnichannel integration and perceived digital value on brand trust formation. Furthermore, it explores the boundary roles of customers’ psychological perceptions in this process, offering a unique and comprehensive perspective.
WELL building for developing countries: critical design criteria for residential buildings in Malaysia
Authors: Zamani Salma Husna , Rahman Rahimi A. , Yusof Liyana Mohamed , Naganathan Hariharan 
Published: June 2024

Purpose
This study aims to investigate the interrelationship between critical design criteria (CDC) that affect health, well-being and productivity (i.e. WELL) for residential buildings in developing countries, using Malaysia as a case study. To achieve the aim, the objectives are to identify CDC that affect WELL collectively; determine CDC that affect health, well-being, and productivity simultaneously; and analyze the interrelationship between the CDC.

Design/methodology/approach
Data from the semi-structured interviews and a systematic review of the existing literature were gathered for survey development. Next, survey data was collected from 114 professionals living in multistory buildings. Finally, normalized mean analysis, analytic hierarchy process (AHP), agreement analysis and Spearman correlation analysis were used to analyze the collected data.

Findings
Out of the 51 potential design criteria, 16 are critically affecting WELL collectively. Furthermore, six are critically affecting WELL collectively as well as health, well-being and productivity simultaneously: property price, water flow and supply, water treatment, pest management, management services and waste management. Finally, “water treatment” is highly correlated to “water management” and “water flow and supply.” In addition, “waste management” and “management services,” as well as “fire safety” and “emergency evacuation plans,” are highly correlated.

Originality/value
This study's originality includes investigating the CDC of residential buildings for the first time, to the best of the authors’ knowledge, in a developing country. As a result, this study uncovers holistic design criteria for policymakers to establish holistic building assessment tools for residential buildings.
Boardroom dynamics: the impact of board gender diversity on discretionary dividend policy in US REITs
Authors: Yousef Ibrahim , Zighan Saad , Aly Doaa , Hussainey Khaled 
Published: June 2024

PurposeThis study aims to address a notable gap in the existing literature by exploring the relationship between gender diversity and dividend policy within the context of US Real Estate Investment Trusts (REITs).Design/methodology/approachThe authors use a substantial data set comprising 1,398 firm-year observations across 209 US REIT companies from 2011 to 2021 to address the research aims. Fixed effects models and generalized least squares regression methods are used in the analysis.FindingsThe results demonstrate a significant positive association between board gender diversity and higher dividend payouts among US REITs. This relationship holds after controlling for corporate governance and other firm-level factors. The findings have strong implications that the presence of women on REIT boards contributes to a greater propensity for discretionary dividend increases in the USA.Originality/valueThis research contributes to the literature by empirically examining female directors’ role in influencing US REITs’ dividend policies, an area lacking adequate prior scholarship. The paper also considers the unique regulatory environment of REITs, highlighting the importance of the study for externally financed firms.
Ethical issues in the halal food supply chain: a systematic bibliometric review
Authors: Mustapha Mohamad Reeduan , Ahamad Farhana , Hazahari Noor Yuslida , Samsudin Nurhusna 
Published: June 2024

Purpose
Systematic reviews have contributed substantially to the development of knowledge in various academic fields and have helped discover new research potentials in a systematic manner. Specifically, this study aims to conduct a systematic bibliometric review to address ethical issues across the halal food supply chain (HFSC), as well as to identify the ethical challenges that food handlers face in ensuring authenticity, compliance with Shariah law and avoidance of contamination with non-halal ingredients in halal food products.

Design/methodology/approach
A bibliometric approach was used to analyse 263 publications from the Scopus database. The present research analysed the documents’ bibliographical data based on publication year, source title, country of origin, institution, authorship, keywords and citation count. The VOSviewer software was applied to perform citation and co-word analysis, as well as to construct bibliometric networks centred on the topic of ethical issues in the HFSC. This bibliometric review provides valuable insights for researchers to identify key publications and comprehend the foundational structure of the subject matter. It also helps guide future research into significant trends and new areas of study.

Findings
Citation analysis provides valuable insights into influential publications and the interconnectedness of research on HFSC. A co-word analysis revealed that discussions on ethics and integrity in the HFSC primarily revolved around the concept of halal and its implications, particularly in supply chain management. However, the limited frequency and prominence of these keywords suggests a scarcity of academic discourse on ethical matters in this field. Moreover, ethical considerations not only serve as a critical aspect of ensuring halal integrity but also emerge as a strategic imperative in marketing, brand management and the operation of global businesses.

Originality/value
This study addresses the need to examine the knowledge gap in the literature on ethical practices and issues in HFSC. Although there is a significant amount of academic writing in the halal context, there is a scarcity of research that specifically focuses on the ethical aspects of HFSC. This study also offers a framework for investigating the ethical practices and issues in HFSC.