bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the interplay of depression, sleep quality, and hearing in tinnitus-related handicap: insights from polysomnography and pure-tone audiometry
Authors: Chang Ting-Gang , Yao Yi-Ting , Hsu Chiann-Yi , Yen Ting-Ting 
Published: June 2024

Abstract
Background
Tinnitus affects approximately 740 million adults globally, involving hearing, emotion, and sleep systems. However, studies using polysomnography and pure-tone audiometry (PTA) are limited. We aimed to assess the correlation between tinnitus and hearing, sleep quality, characteristics, and depression using polysomnography and PTA.

Methods
In this cross-sectional study, we divided participants into tinnitus and non-tinnitus groups. We included 100 outpatients (65 with tinnitus, 35 without) from a medical center in Taiwan, who underwent polysomnography and completed rating scales including the Patient Health Questionnaire-9 (PHQ-9), Chinese version of the Pittsburgh Sleep Quality Index (PSQI), and Chinese-Mandarin version of the Tinnitus Handicap Inventory (THI-CM). We analyzed correlations, conducted group comparisons, assessed factors related to THI-CM scores, constructed ROC curves to predict depression in the tinnitus group, and performed multinomial and logistic regression to explore associations.

Results
Descriptive statistics identified a cohort with mean age 53.9 ± 12.80 years, 63% exhibited PHQ-9 scores ≥ 10, and 66% had Apnea–Hypopnea Index (AHI) > 5. The ratio of rapid eye movement and deep sleep to stage 1 + 2 sleep was relatively low and non-significant. Likewise, leg movements was higher in the tinnitus group but not statistically significant. In the tinnitus group, 63.08% had depression, and 81.54% had AHI > 5. Univariate logistic regression linked tinnitus to AHI > 5 (Odds ratio (OR) 2.67, p = 0.026) and male sex (OR 2.49, p = 0.034). A moderate positive correlation was found between the THI-CM score and PHQ-9 score (rs = 0.50, p < 0.001). Further adjustment for obstructive sleep apnea showed associations between PHQ-9 (total score) or depression and THI-CM Grade 3–5 (OR = 1.28; OR = 8.68). Single- and multifactor regression analyses highlighted significant associations of PSQI scores > 13 (OR 7.06, p = 0.018) and THI-CM scores > 47 (OR 7.43, p = 0.002) with depression.

Conclusions
Our study recruited tinnitus participants with slight or mild hearing loss and mild tinnitus handicap. Depression was identified as a predominant factor in tinnitus-related handicap. The mild tinnitus handicap in tinnitus participants may explain the lack of significant differences in depression, sleep quality, and polysomnographic sleep characteristics between tinnitus and non-tinnitus groups. Further extensive and prospective studies are needed to elucidate the complex links among depression, sleep, and tinnitus.
Only 9% of mothers have eight and more ANC visit in 14 sub-saharan African countries; evidence from the most recent DHS 2018–2023: a multilevel analysis
Authors: Demissie Kaleb Assegid , Jejaw Melak , Wondimu Befikir Gezahegn , Mersha Yekunuamlak Teshome , Demsash Eyuale Sitotaw , Dessie Samuel Getachew , Teshome Asteway Gashaw , Geberu Demiss Mulatu , Tiruneh Misganaw Guadie 
Published: June 2024

Abstract
Background
The world health organization’s global health observatory defines maternal mortality as annual number of female deaths, regardless of the period or location of the pregnancy, from any cause related to or caused by pregnancy or its management (aside from accidental or incidental causes) during pregnancy and childbirth or within 42 days of termination of pregnancy and an estimated 287 000 women worldwide passed away from maternal causes between 2016 and 2020, that works out to be about 800 deaths per day or about one every two minutes.

Method
The most recent 2018–2023 DHS data set of 14 SSA countries was used a total of 89,489 weighted mothers who gave at list one live birth 3 years preceding the survey were included, a multilevel analysis was conducted. In the bi-variable analysis variables with p-value ≤ 0.20 were included in the multivariable analysis, and in the multivariable analysis, variables with p-value less than ≤ 0.05 were considered to be significant factors associated with having eight and more ANC visits.

Result
The magnitude of having eight and more ANC visits in 14 sub-Saharan African countries was 8.9% (95% CI: 8.76–9.13) ranging from 3.66% (95% CI: 3.54–3.79) in Gabon to 18.92% (95% CI: 18.67–19.17) in Nigeria. The multilevel analysis shows that maternal age (40–44, AOR;2.09, 95%CI: 1.75–2.53), maternal occupational status (AOR;1.14, 95%CI; 1.07–1.22), maternal educational level (secondary and above, AOR;1.26, 95%CI; 1.16–1.38), wealth status(AOR;1.65, 95%CI; 1.50–1.82), media exposure (AOR;1.20, 95%CI; 1.11–1.31), pregnancy intention (AOR;1.12, 95%CI; 1.05–1.20), ever had terminated pregnancy (AOR;1.16 95%CI; 1.07–1.25), timely initiation of first ANC visit (AOR;4.79, 95%CI; 4.49–5.10), empowerment on respondents health care (AOR;1.43, 95%CI; 1.30–1.56), urban place of residence (AOR;1.33, 95%CI; 1.22–1.44) were factors highly influencing the utilization of AN. On the other hand higher birth order (AOR;0.54, 95%CI; 0.53–0.66), not using contraceptive (AOR;0.80, 95%CI; 0.75–0.86) and survey year (AOR;0.47, 95%CI; 0.34–0.65) were factors negatively associated with having eight and more ANC visits.

Conclusion
In the 14 SSA included in this study, there is low adherence to WHO guidelines of eight and more ANC visits. Being educated, having jobs, getting access to media being from rural residence and rich wealth group contribute to having eight and more ANC visits, so we highly recommend policy implementers to advocate this practices.
Telling the truth to patients before hip fracture surgery
Authors: Masarwa Rawan , Ben Natan Merav , Berkovich Yaron 
Published: June 2024

Abstract
Background
Hip fracture repair surgery carries a certain mortality risk, yet evidence suggests that orthopedic surgeons often refrain from discussing this issue with patients prior to surgery.

Aim
This study aims to examine whether orthopedic surgeons raise the issue of one-year post-surgery mortality before hip fracture repair surgery and to explore factors influencing this decision.

Method
The study employs a cross-sectional design, administering validated digital questionnaires to 150 orthopedic surgeons.

Results
A minority of orthopedic surgeons reported always informing patients about the risk of mortality in the year following hip fracture surgery. The main reasons for not discussing this risk were a desire to avoid frightening patients, time constraints, and concerns about undermining patient hope. Orthopedic surgeons reported a medium-high level of perceived self-efficacy, with higher self-efficacy associated with a reduced likelihood of discussing one-year mortality risk. Conversely, older age and holding a specialist status in orthopedic surgery were associated with an increased likelihood of discussing this risk with patients.

Conclusions
These findings suggest a need for interventions to address communication barriers and ensure consistent provision of essential information to patients undergoing hip fracture surgery. Additionally, they highlight the importance of considering individual factors such as self-efficacy, age, and expertise in designing strategies to improve patient-provider communication in orthopedic care settings.

Trial registration
: The study doesn`t report the results of a health care intervention.
Quantitative prediction of postpartum hemorrhage in cesarean section on machine learning
Authors: Wang Meng , Yi Gao , Zhang Yunjia , Li Mei , Zhang Jin 
Published: June 2024

Abstract
Background
Cesarean section-induced postpartum hemorrhage (PPH) potentially causes anemia and hypovolemic shock in pregnant women. Hence, it is helpful for obstetricians and anesthesiologists to prepare pre-emptive prevention when predicting PPH occurrence in advance. However, current works on PPH prediction focus on whether PPH occurs rather than assessing PPH amount. To this end, this work studies quantitative PPH prediction with machine learning (ML).

Methods
The study cohort in this paper was selected from individuals with PPH who were hospitalized at Shijiazhuang Obstetrics and Gynecology Hospital from 2020 to 2022. In this study cohort, we built a dataset with 6,144 subjects covering clinical parameters, anesthesia operation records, laboratory examination results, and other information in the electronic medical record system. Based on our built dataset, we exploit six different ML models, including logistic regression, linear regression, gradient boosting, XGBoost, multilayer perceptron, and random forest, to automatically predict the amount of bleeding during cesarean section. Eighty percent of the dataset was used as model training, and 20$$\%$$
%
was used for verification. Those ML models are constantly verified and improved by root mean squared error(RMSE) and mean absolute error(MAE). Moreover, we also leverage the importance of permutation and partial dependence plot (PDP) to discuss their feasibility.

Result
The experiment results show that random forest obtains the highest accuracy for PPH amount prediction compared to other ML methods. Random forest reaches the mean absolute error of 21.7, less than 5.4$$\%$$
%
prediction error. It also gains the root mean squared error of 33.75, less than 9.3$$\%$$
%
prediction error. On the other hand, the experimental results also disclose indicators that contributed most to PPH prediction, including Ca, hemoglobin, white blood cells, platelets, Na, and K.

Conclusion
It effectively predicts the amount of PPH during a cesarean section by ML methods, especially random forest. With the above insight, ML predicting PPH amounts provides early warning for clinicians, thus reducing complications and improving cesarean sections’ safety. Furthermore, the importance of ML and permutation, complemented by incorporating PDP, promises to provide clinicians with a transparent indication of individual risk prediction.
Exploring the perception of safety culture among nurses in Saudi Arabia
Authors: Al Muharraq Essa H. , Abdali Farida , Alfozan Abeer , Alallah Sultan , Sayed Bashaer , Makakam Abdulrahman 
Published: June 2024

Abstract
Background
Medical errors and adverse events pose a serious challenge to the global healthcare industry. Nurses are at the frontline in implementing safety measures and protecting patients. This study aimed to investigate nurses’ perceptions of the patient safety culture in Saudi Arabia.

Methods
This cross-sectional descriptive study used convenience sampling to survey 402 nurses from various hospitals in Jazan, Saudi Arabia. The Hospital Survey on Patient Safety Culture was used for the data collection.

Results
Nurses reported a moderate perception of safety culture, with 60% positive responses. Teamwork had the highest safety culture rating at 77.8%, while responses to error and staffing were the lowest at 39.75% and 46.17%, respectively. Qualifications significantly predicts nurses’ safety culture rating (B = -0442, t = -4.279, p < 0.01). Positive correlations were found between event reporting frequency and communication openness (r = 0.142, p < 0.01), and patient safety grades with communication about errors (r = 0.424, p < 0.01) and hospital management support (r = 0.231, p < 0.01).

Conclusions
Nurses in Saudi Arabia demonstrated a strong sense of teamwork and commitment to organizational learning. However, critical areas such as staffing and error response require attention to improve patient safety.
Early parent-child intervention with Dialogic Book-Sharing: effects on child communicative and socio-emotional development and on parenting. Study protocol for a multicentre randomised controlled trial in Italy
Authors: Loredana Cena , Alice Trainini , Lynne Murray , Peter Cooper , Stefano Calza , Mauro Belluardo 
Published: June 2024

Abstract
Background
Research in the neurosciences has highlighted the importance of intersubjective relationships in promoting neuromental development of the child. Children’s learning in early childhood occurs mainly in a dyadic context of an interaction with their parents: from this perspective, good dialogic parent–child communication is required to be promoted also through good educational practices. Dialogic Book-Sharing (DBS), a dialogic form of parent–child communication through the use of wordless picture books, provides a privileged ‘intersubjective’ space and is highly effective in promoting communication, language, attention, behavioural development and the parent–child relationship. DBS programme, successfully previously trialled in South Africa and the UK, will be applied for the first time in Italy for research purposes in Italian health, educational and maternal-child centres.

Methods
A multicentre randomised controlled trial is being conducted to evaluate DBS parenting intervention for children aged between 14 and 20 months. Parent–child dyads are randomly allocated to a book-sharing intervention group or to a wait-list control group. In the intervention, parents are trained in supportive book-sharing with their children by local staff of the centres. DBS intervention is carried out in small groups over a period of 4 weeks. Data are collected at baseline, post-intervention and at 6 months post-intervention with a questionnaire and video recording of parent–child interaction.

Discussion
DBS programme in early childhood could enhance the educational resources offered by Italian health, educational and maternal-child centres, in support of child’s development and parenting. DBS represents a strategic opportunity for bringing about positive effects, also in terms of prevention of socio-emotional and cognitive difficulties. As such it represents a promising response to the new social, health and educational needs of the post-COVID-19 pandemic era caused by the social isolation measures. Furthermore, the application of the DBS methodology is a way to promote the use of books, and thereby counteract the excessive use of technological devices already present in early childhood.

Trial registration
The trial is registered on the International Standard Randomised Controlled Trial Number database, registration number ISRCTN11755019 Registered on 2 November 2023. This is version 1 of the protocol for the trial.
Nutritional interventions in children with acute lymphoblastic leukemia undergoing antineoplastic treatment: a systematic review
Authors: Guzmán-León Alan E. , Avila-Prado Jessica , Bracamontes-Picos Leslie R. , Haby Michelle M. , Stein Katja , Astiazaran-Garcia Humberto , Lopez-Teros Veronica 
Published: June 2024

Abstract
Background
A compromised nutritional status jeopardizes a positive prognosis in acute lymphoblastic leukemia (ALL) patients. In low- and middle-income countries, ~ 50% of children with ALL are malnourished at diagnosis time, and undergoing antineoplastic treatment increases the risk of depleting their nutrient stores. Nutrition interventions are implemented in patients with cancer related malnutrition. We aimed to evaluate the effect of nutrition interventions in children diagnosed with ALL under treatment.

Methods
Using a predefined protocol, we searched for published or unpublished randomized controlled trials in: Cochrane CENTRAL, MEDLINE, EMBASE, LILACS, and SciELO, and conducted complementary searches. Studies where at least 50% of participants had an ALL diagnosis in children ≤ 18 years, active antineoplastic treatment, and a nutrition intervention were included. Study selection and data extraction were conducted independently by three reviewers, and assessment of the risk of bias by two reviewers. Results were synthesized in both tabular format and narratively.

Results
Twenty-five studies (out of 4097 records) satisfied the inclusion requirements. There was a high risk of bias in eighteen studies. Interventions analyzed were classified by compound/food (n = 14), micronutrient (n = 8), and nutritional support (n = 3). Within each group the interventions and components (dose and time) tested were heterogeneous. In relation to our primary outcomes, none of the studies reported fat-free mass as an outcome. Inflammatory and metabolic markers related to nutritional status and anthropometric measurements were reported in many studies but varied greatly across the studies. For our secondary outcomes, fat mass or total body water were not reported as an outcome in any of the studies. However, some different adverse events were reported in some studies.

Conclusions
This review highlights the need to conduct high-quality randomized controlled trials for nutrition interventions in children with ALL, based on their limited number and heterogeneous outcomes.

Registration of the review protocol
Guzmán-León AE, Lopez-Teros V, Avila-Prado J, Bracamontes-Picos L, Haby MM, Stein K. Protocol for a Systematic Review: Nutritional interventions in children with acute lymphoblastic leukemia undergoing an tineoplastic treatment. International prospective register of systematic reviews. 2021; PROSPERO CRD:42,021,266,761 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=266761).
Vaccine Progress, Stock Prices, and the Value of Ending the Pandemic
Authors: Acharya Viral V. , Johnson Timothy , Sundaresan Suresh , Zheng Steven 
Published: June 2024

One measure of the ex ante cost of disasters is the welfare gain from shortening their expected duration. We introduce a stochastic clock into a standard disaster model that summarizes information about progress (positive or negative) toward disaster resolution. We show that the stock market response to duration news is essentially a sufficient statistic to identify the welfare gain to interventions that alter the state. Using information on clinical trial progress during 2020, we build contemporaneous forecasts of the time to vaccine deployment, which provide a measure of the anticipated length of the COVID-19 pandemic. The model can thus be calibrated from market reactions to vaccine news, which we estimate. The estimates imply that ending the pandemic would have been worth from 5% to 15% of total wealth as the expected duration varied in this period. This paper was accepted by Lukas Schmid, finance. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00863 .
Dynamics for wave equations connected in parallel with nonlinear localized damping
Authors: Gao Yunlong , Sun Chunyou , Zhang Kaibin 
Published: June 2024

Abstract
This study investigates the properties of solutions about one-dimensional wave equations connected in parallel under the effect of two nonlinear localized frictional damping mechanisms. First, under various growth conditions about the nonlinear dissipative effect, we try to establish the decay rate estimates by imposing minimal amount of support on the damping and provide some examples of exponential decay and polynomial decay. To achieve this, a proper observability inequality has been proposed and constructed based on some refined microlocal analysis. Then, the existence of a global attractor is proved when the damping terms are linearly bounded at infinity, a special weighting function has been used in this part, which eliminates undesirable terms of the higher order while contributing lower-order terms. Finally, we establish that the long-time behavior of solutions of the nonlinear system is completely determined by the dynamics of large finite number of functionals.
In silico analysis: Fulleropyrrolidine derivatives against HIV-PR mutants and SARS-CoV-2 Mpro
Authors: Saleh Noha A. 
Published: June 2024

Abstract
Approximately 37.9 million people living with HIV (PLWH) are at risk of severe consequences from COVID-19. Urgent development of tailored treatments for PLWH, who have historically been excluded from vaccine trials, is crucial. The present study introduces some modified fulleropyrrolidine derivatives with chalcogen atoms (O, S, or Se) and hydroxymethylcarbonyl (HMC) groups to target 11 single and double HIV-1 protease (HIV-PR) mutations and the main protease of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 Mpro). The inhibitory activities of these derivatives are computationally examined through molecular docking, molecular dynamic simulations for 200 ns, and Lipinski’s rule of five (RO5). Fourier-transform infrared spectroscopy spectra and thermodynamic properties are calculated and analyzed using Density Functional Theory B88-PW91 method. The results indicate that the suggested O-compounds obey three parameters of the RO5 and HMC forms hydrogen bonds with studied viral proteases. Compounds with O and S additives display a high binding affinity with negative binding energy values for HIV-PR mutations (A71V-I84V, V77I-I84V, and I84V-L90M) and SARS-CoV-2 Mpro. The compounds with S and Se additives shift to lower frequencies of the major vibrational bands. Specifically, compound 1, with two oxygen additives, emerges as the most effective in inhibiting both HIV-PR mutations and SARS-CoV-2 Mpro.
Transparenzberichterstattung der genossenschaftlichen Prüfungsverbände
Authors: Quick Reiner 
Published: June 2024

Zusammenfassung
Genossenschaftliche Prüfungsverbände sind zur Transparenzberichterstattung verpflichtet, sofern sie Genossenschaften von öffentlichem Interesse prüfen. Ihre Transparenzberichterstattung wurde in der Forschung bislang noch nicht untersucht. Inhaltsanalysen zeigen auf, dass die gesetzlichen Anforderungen größtenteils erfüllt sind. Die Lesbarkeit der Berichte ist vergleichsweise hoch. Allerdings unterscheiden sich die Transparenzberichte im Zeitablauf wenig. Die Transparenzberichte sind des Weiteren durch ein hohes Maß an Selbstvertrauen und Kompetenz gekennzeichnet sowie eher pessimistisch und vorsichtig formuliert.
Evaluation of the Learning Program for Physical Education Sports and Health Basic Locomotor Movement Material at State Elementary Schools in Tabir District, Merangin Regency, Jambi
Authors: Yogi Afrisandy Pratama , Arsil Arsil , Bakhtiar Syahrial , Syahrastani Syahrastani 
Published: June 2024

This study aims to evaluate the learning program of Physical Education Sports and Health of basic locomotor movements in Tabir District Public Elementary School, Merangin Regency Jambi, with aspects of the relevance of learning to the merdeka curriculum, the background of physical education sports and health (PJOK) teachers and facilities and infrastructure, the process of implementing Physical Education Sports and Health (PJOK) learning, and the value received during learning. This type of research is qualitative research with a program evaluation method. The design of the research model to be used is based on the CIPP model which involves all parties in the evaluation. Data collection techniques in this study using interviews, documentation, and observation methods. The results of this study from the Context aspect, the PJOK learning program for locomotor basic movement material of State Elementary Schools in Tabir District, Merangin Regency, Jambi is relevant to the Merdeka curriculum that is being implemented in schools. From the Input aspect, public elementary physical education teachers in Tabir District, Merangin Jambi Regency have an undergraduate educational background (S1) in sports education who have completed their education from various universities in Sumatra. From the aspect of facilities and infrastructure in public elementary schools in Tabir District, Merangin Jambi Regency, it is still incomplete. In the process of implementing learning, teachers have used teaching modules and ATP (flow of learning objectives) in accordance with the MERDEKA curriculum but teachers are still learning the curriculum because in some schools there are still teachers who have never attended training related to the merdeka curriculum. From the Product aspect, the achievement of PJOK learning outcomes in the basic locomotor material of State Elementary Schools in Tabir District, Merangin Regency, Jambi has not been maximized. This can be seen from the scores of students who are still below the KKM.