bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting suitable areas for Metcalfa pruinosa (Hemiptera: Flatidae) under climate change and implications for management
Authors: Zhao Zhengxue , Yang Lin , Long Jiankun , Chang Zhimin , Chen Xiangsheng 
Published: May 2024

Abstract
Climate change is a prominent factor reshaping the distribution of invasive species. Metcalfa pruinosa (Say 1830) (Hemiptera: Flatidae), native to North America, has invaded other continents and poses a serious threat to various agricultural crops and the human residential environment. Understanding the distribution of M. pruinosa based on climatic conditions is a critical first step to prevent its further invasion. Therefore, based on its occurrence records and associated environmental variables, a Maxent model was developed to predict suitable areas for this species in the present and future on a global scale. The model exhibited outstanding performance, with a mean area under the receiver operating characteristic curve and true skill statistic values of 0.9329 and 0.926, respectively. The model also indicated that annual precipitation (Bio12) and max temperature of the warmest month (Bio5) were the key environmental variables limiting the distribution of M. pruinosa. Moreover, the model revealed that the current suitable area is 1.01 × 107 km2 worldwide, with southern China, southern Europe, and the eastern United States predicted to be the primary and highly suitable areas in the latter 2 regions. This area is expected to increase under future climate scenarios, mainly in the northern direction. The study’s findings contribute to our understanding of climate change’s impact on M. pruinosa distribution, and they will aid governments in developing appropriate pest management strategies, including global monitoring and strict quarantine measures.
Immune-related adverse event-associated sclerosing cholangitis due to immune checkpoint inhibitors: imaging findings and treatments
Authors: Okamoto Kohei , Hijioka Susumu , Nagashio Yoshikuni , Okada Mao , Ohba Akihiro , Maruki Yuta , Kondo Shunsuke , Morizane Chigusa , Ueno Hideki , Okusaka Takuji 
Published: May 2024

Abstract

Objectives
Immune-related adverse event-sclerosing cholangitis caused by treatment with immune checkpoint inhibitors is rare, and the diagnostic criteria and treatment strategy remain unclear. In this study, we confirmed the clinicopathological features of immune-related adverse event-sclerosing cholangitis and clarified its diagnosis and appropriate management.

Methods
We retrospectively evaluated 10 patients diagnosed with immune-related adverse event-sclerosing cholangitis and identified by electronic database searches.

Results
Blood tests revealed liver dysfunction with a predominance of biliary tract enzymes in all patients; however, jaundice was present in only one patient. Contrast-enhanced computed tomography revealed diffuse hypertrophy of the extrahepatic bile duct wall as the most frequent finding; however, endoscopic retrograde cholangiopancreatography showed various imaging features, such as the pruned-tree appearance of intrahepatic bile ducts, in all patients. Transpapillary bile duct biopsy showed inflammatory cell infiltration using immunostaining, with a predominance of cluster of differentiation 8-positive T cells in 63% of the cases. Initial steroid therapy was effective in two cases. Mycophenolate mofetil and tacrolimus were used in steroid-refractory cases. Although six patients showed improvements, all of the remaining patients died owing to immune-related adverse event-sclerosing cholangitis.

Conclusions
Various bile duct imaging findings of immune-related adverse event-sclerosing cholangitis were revealed; transpapillary bile duct biopsy may be useful in the diagnosis of immune-related adverse event-sclerosing cholangitis. Despite the combination of multiple immunosuppressive agents, prognosis of immune-related adverse event-sclerosing cholangitis remains poor. Longer follow-up and larger clinical studies are necessary to establish its treatment strategy.
Lifetime reproductive characteristics of gray wolves
Authors: Ausband David E 
Published: May 2024

Abstract
Female and male cooperative breeders can use different strategies to maximize reproduction and fitness over their lifetimes. Answering questions about fitness in cooperative breeders requires long-term studies as well as complete data on group composition and size which can be exceedingly difficult to obtain. Using a long-term genetic data set of complete group pedigrees, I asked how lifetime reproductive characteristics of female and male gray wolves (Canis lupus) differed. I predicted that genetic relatedness to helpers would be higher for females than males due to philopatric behavior of female wolves, group size would be similar between the sexes, females would inherit breeding positions from within groups more often than males due to differences in dispersal strategies between the sexes, males would have more lifetime mates and produce more young than females because of polygamy, and females would breed for more years than males due to the likelihood that females would still breed (with a new partner) after a mate died or was expelled from the group. I documented complete lifetime breeding histories for 11 male and 18 female wolves in Idaho, United States, 2008 to 2018. Genetic relatedness to helpers, group size, number of mates, pups, and years breeding did not differ between the sexes. Females, however, inherited breeding positions within groups far more often than males. Individuals who secured breeding positions generally reproduced for 2 seasons and commonly had more than 1 partner during their lifetimes if they were able to maintain their breeding position longer. Direct fitness varied greatly within female and male breeding wolves.
Pain response in single-fraction 8-Gy radiotherapy for painful non-bone-metastasis tumors: a single-center retrospective study
Authors: Imano Nobuki , Kosugi Takashi , Konishi Kenta , Saito Tetsuo 
Published: May 2024

Abstract
The effectiveness of single-fraction 8-Gy radiotherapy for painful bone metastases has been verified in numerous randomized controlled trials. However, few reports have described the effectiveness of single-fraction 8-Gy radiotherapy in painful tumors other than bone metastases. We conducted a retrospective analysis to evaluate the pain response to single-fraction 8-Gy radiotherapy in painful non-bone-metastasis tumors. We included patients who had received single-fraction 8-Gy radiotherapy for such tumors between January 2017 and December 2022, excluding those with brain metastases, hematological tumors and those who received re-irradiation. Pain response assessment was based on the best responses documented in the medical records and conducted by two radiation oncologists. A total of 36 eligible patients were included in this study. The irradiation sites included primary lesions in eight patients, lymph node metastases in eight, muscle metastases in seven, pleural dissemination in four, skin/subcutaneous metastases in four and other sites in five. Pain response was assessed in 24 patients after radiotherapy. Pain response rate was 88% in evaluable patients; 21 of the 24 patients experienced response. The median assessment date for pain response was 37 days (range: 8–156 days) after radiotherapy. Re-irradiation was performed in four patients (11%). Single-fraction 8-Gy radiotherapy seemed to be a promising treatment option for painful non-bone-metastasis tumors and warrants further investigation.
Age-specific reference scores for the PISQ-12 on female sexual functioning in the Netherlands: a retrospective population-based survey
Authors: Hierink G Marije , Brinkman Lauret A M , Hogenhout Sietske A , Malmberg G G Alec , Trzpis Monika , van Eijndhoven Hugo W F , Broens Paul M A 
Published: May 2024

Abstract

Background
Female sexual dysfunction is common in the general population, with age emerging as a significant determinant of sexual activity and functioning.

Aim
To establish age-specific reference scores for the Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12) in the general Dutch female population.

Methods
A retrospective, cross-sectional, questionnaire-based study was conducted in the Netherlands. The study population comprised 2518 Dutch-speaking women aged ≥18 years, representing a cross section of the general Dutch population. The PISQ-12 was used to assess sexual functioning in heterosexual women. The Groningen Defecation and Fecal Continence questionnaire was utilized to demonstrate demographic factors.

Outcomes
We established age-specific reference scores for the PISQ-12 in the general Dutch population.

Results
Of the 2518 women, 1592 (63.2%) were sexually active and 926 (36.8%) were not. Further analysis focused on the sexually active group: we found a decrease in mean total PISQ scores, ranging from 38.34 among 18- to 34-year-olds to 36.98 among ≥65-year-olds. Older women scored lower in the behavior domain, specifically pertaining to sexual desire (P &lt; .001) and sexual excitement (P &lt; .001). They also had lower scores in the partner-related domain regarding partner problems of erection (P &lt; .001) and orgasm perception (P &lt; .001). With increasing age, negative emotional reaction scores were higher (P &lt; .001). In the physical domain, we observed significantly different scores for pain during sexual intercourse (P &lt; .001) and restrictions in sexual activity due to fear of urinary leakage (P &lt; .001), with the lowest scores in the youngest group.

Clinical Implications
These age-specific references scores of the PISQ-12 provide an overview of sexual functioning of a general population, which enables caregivers to assess and interpret patients’ individual scores more accurately.

Strengths and Limitations
We included only sexually active women in our subanalyses, potentially introducing selection bias for older women with better physical conditions. The study’s strength lies in its extensive sample size, representing a cross section of the general Dutch population. Furthermore, the self-administered questionnaire approach helped minimize embarrassment and obtain realistic responses.

Conclusion
Our study demonstrated age-specific PISQ-12 reference scores and highlighted associations between aging and diminishing scores of sexual desire, sexual excitement, erection problems, and orgasm perception, while women aged 18 to 34 years reported the lowest scores for pain during intercourse and limited sexual activity due to fear of urinary leakage.
Application of deep learning for the analysis of stomata: a review of current methods and future directions
Authors: Gibbs Jonathon A , Burgess Alexandra J 
Published: May 2024

AbstractPlant physiology and metabolism rely on the function of stomata, structures on the surface of above-ground organs that facilitate the exchange of gases with the atmosphere. The morphology of the guard cells and corresponding pore that make up the stomata, as well as the density (number per unit area), are critical in determining overall gas exchange capacity. These characteristics can be quantified visually from images captured using microscopy, traditionally relying on time-consuming manual analysis. However, deep learning (DL) models provide a promising route to increase the throughput and accuracy of plant phenotyping tasks, including stomatal analysis. Here we review the published literature on the application of DL for stomatal analysis. We discuss the variation in pipelines used, from data acquisition, pre-processing, DL architecture, and output evaluation to post-processing. We introduce the most common network structures, the plant species that have been studied, and the measurements that have been performed. Through this review, we hope to promote the use of DL methods for plant phenotyping tasks and highlight future requirements to optimize uptake, predominantly focusing on the sharing of datasets and generalization of models as well as the caveats associated with utilizing image data to infer physiological function.
What the eyes, confidence, and partner’s identity can tell about change of mind
Authors: Sanchez Rémi , Tomei Anne-Catherine , Mamassian Pascal , Vidal Manuel , Desantis Andrea 
Published: May 2024

Abstract
Perceptual confidence reflects the ability to evaluate the evidence that supports perceptual decisions. It is thought to play a critical role in guiding decision-making. However, only a few empirical studies have actually investigated the function of perceptual confidence. To address this issue, we designed a perceptual task in which participants provided a confidence judgment on the accuracy of their perceptual decision. Then, they viewed the response of a machine or human partner, and they were instructed to decide whether to keep or change their initial response. We observed that confidence predicted participants’ changes of mind more than task difficulty and perceptual accuracy. Additionally, interacting with a machine, compared to a human, decreased confidence and increased participants tendency to change their initial decision, suggesting that both confidence and changes of mind are influenced by contextual factors, such as the identity of a partner. Finally, variations in confidence judgments but not change of mind were correlated with pre-response pupil dynamics, indicating that arousal changes are linked to confidence computations. This study contributes to our understanding of the factors influencing confidence and changes of mind and also evaluates the possibility of using pupil dynamics as a proxy of confidence.
Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile
Authors: Nussbaumer Gunther , Benesch Martin , Grabovska Yura , Mackay Alan , Castel David , Grill Jacques , Alonso Marta M , Antonelli Manila , Bailey Simon , Baugh Joshua N , Biassoni Veronica , Blattner-Johnson Mirjam , Broniscer Alberto , Carai Andrea , Colafati Giovanna Stefania , Colditz Niclas , Corbacioglu Selim , Crampsie Shauna , Entz-Werle Natacha , Eyrich Matthias , Friker Lea L , Frühwald Michael C , Garrè Maria Luisa , Gerber Nicolas U , Giangaspero Felice , Gil-da-Costa Maria J , Graf Norbert , Hargrave Darren , Hauser Peter , Herrlinger Ulrich , Hoffmann Marion , Hulleman Esther , Izquierdo Elisa , Jacobs Sandra , Karremann Michael , Kattamis Antonis , Kebudi Rejin , Kortmann Rolf-Dieter , Kwiecien Robert , Massimino Maura , Mastronuzzi Angela , Miele Evelina , Morana Giovanni , Noack Claudia M , Pentikainen Virve , Perwein Thomas , Pfister Stefan M , Pietsch Torsten , Roka Kleoniki , Rossi Sabrina , Rutkowski Stefan , Schiavello Elisabetta , Seidel Clemens , Štěrba Jaroslav , Sturm Dominik , Sumerauer David , Tacke Anna , Temelso Sara , Valentini Chiara , van Vuurden Dannis , Varlet Pascale , Veldhuijzen van Zanten Sophie E M , Vinci Maria , von Bueren André O , Warmuth-Metz Monika , Wesseling Pieter , Wiese Maria , Wolff Johannes E A , Zamecnik Josef , Morales La Madrid Andrés , Bison Brigitte , Gielen Gerrit H , Jones David T W , Jones Chris , Kramm Christof M 
Published: May 2024

Abstract

Background
The term gliomatosis cerebri (GC), a radiology-defined highly infiltrating diffuse glioma, has been abandoned since molecular GC-associated features could not be established.

Methods
We conducted a multinational retrospective study of 104 children and adolescents with GC providing comprehensive clinical and (epi-)genetic characterization.

Results
Median overall survival (OS) was 15.5 months (interquartile range, 10.9–27.7) with a 2-year survival rate of 28%. Histopathological grading correlated significantly with median OS: CNS WHO grade II: 47.8 months (25.2–55.7); grade III: 15.9 months (11.4–26.3); grade IV: 10.4 months (8.8–14.4). By DNA methylation profiling (n = 49), most tumors were classified as pediatric-type diffuse high-grade glioma (pedHGG), H3-/IDH-wild-type (n = 31/49, 63.3%) with enriched subclasses pedHGG_RTK2 (n = 19), pedHGG_A/B (n = 6), and pedHGG_MYCN (n = 5), but only one pedHGG_RTK1 case. Within the pedHGG, H3-/IDH-wild-type subgroup, recurrent alterations in EGFR (n = 10) and BCOR (n = 9) were identified. Additionally, we observed structural aberrations in chromosome 6 in 16/49 tumors (32.7%) across tumor types. In the pedHGG, H3-/IDH-wild-type subgroup TP53 alterations had a significant negative effect on OS.

Conclusions
Contrary to previous studies, our representative pediatric GC study provides evidence that GC has a strong predilection to arise on the background of specific molecular features (especially pedHGG_RTK2, pedHGG_A/B, EGFR and BCOR mutations, chromosome 6 rearrangements).
Proton pump inhibitors are detrimental to overall survival of patients with glioblastoma: Results from a nationwide real-world evidence database
Authors: Castro Michael P , Quinn Jameson , Wasserman Asher , Awawda Alaa , Cole Zachariah D , Shapiro Mark A , Stuhlmiller Timothy J , Kesari Santosh 
Published: May 2024

Abstract

Background
Proton pump inhibitors (PPIs) are often prescribed to manage corticosteroid-induced gastrointestinal toxicity during glioblastoma (GBM) treatment, but were recently identified as strong inducers of aldehyde dehydrogenase-1A1 (ALDH1A1). ALDH1A1 is a primary metabolic enzyme impacting the outcome of chemotherapy, including temozolomide. High expression of ALDH1A1 is associated with poor prognosis in multiple cancers, suggesting PPIs may have a negative impact on survival.

Methods
Real-world data on GBM patients was annotated from electronic medical records (EMR) according to the prospective observational study, XCELSIOR (NCT03793088). Patients with known IDH1/2 mutations were excluded. Causal effects on survival were analyzed using a multivariate, time-varying Cox Proportional Hazard (CPH) model with stratifications including MGMT methylation status, age, sex, duration of corticosteroid use, extent of resection, starting standard-of-care, and PPI use.

Results
EMR data from 554 GBM patients across 225 cancer centers was collected, with 72% of patients receiving care from academic medical centers. Patients treated with PPIs (51%) had numerically lower median overall survival (mOS) and 2-year OS rates in the total population and across most strata, with the greatest difference for MGMT-methylated patients (mOS 29.2 vs. 40.1 months). In a time-varying multivariate CPH analysis of the above strata, PPIs caused an adverse effect on survival (HR 1.67 [95% CI: 1.15–2.44], P = .007).

Conclusions
Evidence from a nationwide cancer registry has suggested PPIs have a negative impact on OS for GBM patients, particularly those with MGMT promoter methylation. This suggests PPIs should be avoided for prophylactic management of gastrointestinal toxicity in patients with GBM receiving chemoradiotherapy.
Effects of deficiency or supplementation of riboflavin on energy metabolism: a systematic review with preclinical studies
Authors: da Silva-Araújo Eulália Rebeca , Toscano Ana Elisa , Silva Paula Brielle Pontes , Pereira dos Santos Junior Joaci , Gouveia Henrique José Cavalcanti Bezerra , da Silva Márcia Maria , Souza Vanessa da Silva , de Freitas Silva Sebastião Rogério , Manhães-de-Castro Raul 
Published: May 2024

Abstract

Context
Riboflavin (vitamin B2) is a water-soluble micronutrient considered to be a precursor of the nucleotides flavin adenine dinucleotide and flavin mononucleotide. This vitamin makes up mitochondrial complexes and participates as an enzymatic cofactor in several mechanisms associated with energy metabolism.

Objective
This systematic review collected and discussed the most relevant results on the role of riboflavin in the energy metabolism of lipids, proteins, and carbohydrates.

Data Sources
A systematic search was carried out in the PubMed-Medline, Scopus, Embase, and Web of Science databases using the PICOS (Population, Intervention, Comparison, Outcome, Study design) strategy.

Data Extraction
The screening of studies went through 2 stages following predefined eligibility criteria. The information extracted covered reference details, study design, population characteristics, experimental model, treatment parameters and dosage, route of administration, duration of treatment, and results found.

Data Analysis
The risk of bias was assessed using the SYRCLE Risk of Bias (RoB) tool for in vivo studies and the QUIN tool adapted for in vitro studies, utilizing 10 domains, including selection bias, performance bias, detection bias, attrition bias, reporting bias, and other biases, to evaluate the methodological quality of the included studies.

Conclusion
This review concludes that riboflavin regulates energy metabolism by activating primary metabolic pathways and is involved in energy balance homeostasis.
A Mediterranean diet improves glycation markers in healthy people and in those with chronic diseases: a systematic review of clinical trials
Authors: Oliveira Julia S , da Silva Jessica A , de Freitas Brenda V M , Alfenas Rita C G , Bressan Josefina 
Published: May 2024

Abstract

Context
Consumption of the Mediterranean diet (MedDiet) has beneficial effects on cardiometabolic health and aging.

Objective
This systematic review aimed to critically investigate the effect of the MedDiet on glycation markers in healthy or overweight individuals with type 2 diabetes or cardiovascular disease.

Data Sources
MEDLINE, EMBASE, Web of Science, and the Cochrane Library were searched, using the terms “Mediterranean diet” AND “glycation end products, advanced”.

Data Extraction
Three randomized and 3 nonrandomized clinical trials, containing data on 2935 adult and elderly individuals with normal weight or overweight, were included. All extracted data were compiled, compared, and critically analyzed.

Data Analysis
The authors of most of the studies demonstrated a reduction in serum concentrations of advanced glycation end products (AGEs), such as εN-carboxymethyllysine and methylglyoxal, and in skin autofluorescence levels after at least 4 weeks of adherence to the MedDiet. The MedDiet also led to positive effects on gene expression of receptors for AGEs, as RAGE and AGER1, and an enzyme involved in detoxification (glyoxalase I). There is no evidence that short-term adherence affects glycation markers.

Conclusions
Glycation markers improved in response to the MedDiet. The possible mechanisms involved may be related to the low AGE and refined sugars content of the diet, as well as its high monounsaturated fatty acid, phenolic compound, and dietary fiber contents.

Systematic Review Registration
PROSPERO registration no. CRD42021284006.
Antifungals in Patients With Extracorporeal Membrane Oxygenation: Clinical Implications
Authors: Kriegl Lisa , Hatzl Stefan , Schilcher Gernot , Zollner-Schwetz Ines , Boyer Johannes , Geiger Christina , Hoenigl Martin , Krause Robert 
Published: May 2024

Abstract
Extracorporeal membrane oxygenation (ECMO) is a life-saving technique used in critical care medicine for patients with severe respiratory or cardiac failure. This review examines the treatment and prophylaxis of fungal infections in ECMO patients, proposing specific regimens based on available data for different antifungals (azoles, echinocandins, amphotericin B/liposomal amphotericin B) and invasive fungal infections. Currently, isavuconazole and posaconazole have the most supported data, while modified dosages of isavuconazole are recommended in ECMO. Echinocandins are preferred for invasive candidiasis. However, choosing echinocandins is challenging due to limited and varied data on concentration loss in the ECMO circuit. Caution is likewise advised when using liposomal amphotericin B due to uncertain concentrations and potential ECMO dysfunction based on scarce data. We further conclude with the importance of further research on the impact of ECMO on antifungal drug concentrations to optimize dosing regimens in critically ill patients.