bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sensitive Cardiac Troponin T Assay and the Risk of Incident Cardiovascular Disease in Women With and Without Diabetes Mellitus
Authors: Everett Brendan M. , Cook Nancy R. , Magnone Maria C. , Bobadilla Maria , Kim Eunjung , Rifai Nader , Ridker Paul M , Pradhan Aruna D. 
Published: June 2011

Background—
Very low levels of cardiac troponin T are associated with an increased risk of cardiovascular death in patients with stable chronic coronary disease. Whether high-sensitivity cardiac troponin T levels are associated with adverse cardiovascular outcomes in individuals without cardiovascular disease (CVD) has not been well studied.

Methods and Results—

Using 2 complementary study designs, we evaluated the relationship between baseline cardiac troponin and incident CVD events among diabetic and nondiabetic participants in the Women's Health Study (median follow-up, 12.3 years). All diabetic women with blood specimens were included in a cohort study (n=512 diabetic women, n=65 events), and nondiabetic women were sampled for inclusion in a case-cohort analysis (n=564 comprising the subcohort, n=479 events). High-sensitivity cardiac troponin T was detectable (≥0.003 μg/L) in 45.5% of diabetic women and 30.3% of nondiabetic women (
P
<0.0001). In models adjusted for traditional risk factors and hemoglobin A
1c
, detectable high-sensitivity cardiac troponin T was associated with subsequent CVD (myocardial infarction, stroke, cardiovascular death) in diabetic women (adjusted hazard ratio, 1.79; 95% confidence interval, 1.04 to 3.07,
P
=0.036) but not nondiabetic women (adjusted hazard ratio, 1.13; 95% confidence interval, 0.82 to 1.55;
P
=0.46). Further adjustment for amino-terminal pro-B-type natriuretic peptide and estimated renal function did not substantially alter this relationship among diabetic women (hazard ratio, 1.76; 95% confidence interval, 1.00 to 3.08;
P
=0.0499), which appeared to be driven by a 3-fold increase in CVD death that was not observed in nondiabetic women.

Conclusions—
Very low but detectable levels of cardiac troponin T are associated with total CVD and CVD death in women with diabetes mellitus. Among healthy nondiabetic women, detectable compared with undetectable troponin was not associated with CVD events.
Calcineurin Splicing Variant Calcineurin Aβ1 Improves Cardiac Function After Myocardial Infarction Without Inducing Hypertrophy
Authors: Felkin Leanne E. , Narita Takuya , Germack Renée , Shintani Yasunori , Takahashi Kunihiko , Sarathchandra Padmini , López-Olañeta Marina M. , Gómez-Salinero Jesús M. , Suzuki Ken , Barton Paul J.R. , Rosenthal Nadia , Lara-Pezzi Enrique 
Published: June 2011

Background—
Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the calcineurin Aβ (CnAβ) gene generates the CnAβ1 isoform, with a unique C-terminal region that is different from the autoinhibitory domain present in all other CnA isoforms. In skeletal muscle, CnAβ1 is necessary for myoblast proliferation and stimulates regeneration, reducing fibrosis and accelerating the resolution of inflammation. Its role in the heart is currently unknown.

Methods and Results—
We generated transgenic mice overexpressing CnAβ1 in postnatal cardiomyocytes under the control of the α-myosin heavy chain promoter. In contrast to previous studies using an artificially truncated calcineurin, CnAβ1 overexpression did not induce cardiac hypertrophy. Moreover, transgenic mice showed improved cardiac function and reduced scar formation after myocardial infarction, with reduced neutrophil and macrophage infiltration and decreased expression of proinflammatory cytokines. Immunoprecipitation and Western blot analysis showed interaction of CnAβ1 with the mTOR complex 2 and activation of the Akt/SGK cardioprotective pathway in a PI3K-independent manner. In addition, gene expression profiling revealed that CnAβ1 activated the transcription factor ATF4 downstream of the Akt/mTOR pathway to promote the amino acid biosynthesis program, to reduce protein catabolism, and to induce the antifibrotic and antiinflammatory factor growth differentiation factor 15, which protects the heart through Akt activation.

Conclusions—
Calcineurin Aβ1 shows a unique mode of action that improves cardiac function after myocardial infarction, activating different cardioprotective pathways without inducing maladaptive hypertrophy. These features make CnAβ1 an attractive candidate for the development of future therapeutic approaches.
Early Repolarization
Authors: Tikkanen Jani T. , Junttila M. Juhani , Anttonen Olli , Aro Aapo L. , Luttinen Samuli , Kerola Tuomas , Sager Solomon J. , Rissanen Harri A. , Myerburg Robert J. , Reunanen Antti , Huikuri Heikki V. 
Published: June 2011

Background—
Early repolarization (ER) in inferior/lateral leads of standard ECGs increases the risk of arrhythmic death. We tested the hypothesis that variations in the ST-segment characteristics after the ER waveforms may have prognostic importance.

Methods and Results—
ST segments after ER were classified as horizontal/descending or rapidly ascending/upsloping on the basis of observations from 2 independent samples of young healthy athletes from Finland (n=62) and the United States (n=503), where ascending type was the dominant and common form of ER. Early repolarization was present in 27/62 (44%) of the Finnish athletes and 151/503 (30%) of the US athletes, and all but 1 of the Finnish (96%) and 91/107 (85%) of US athletes had an ascending/upsloping ST variant after ER. Subsequently, ECGs from a general population of 10 864 middle-aged subjects were analyzed to assess the prognostic modulation of ER-associated risk by ST-segment variations. Subjects with ER ≥0.1 mV and horizontal/descending ST variant (n=412) had an increased hazard ratio of arrhythmic death (relative risk 1.43; 95% confidence interval 1.05 to 1.94). When modeled for higher amplitude ER (>0.2 mV) in inferior leads and horizontal/descending ST-segment variant, the hazard ratio of arrhythmic death increased to 3.14 (95% confidence interval 1.56 to 6.30). However, in subjects with ascending ST variant, the relative risk for arrhythmic death was not increased (0.89; 95% confidence interval 0.52 to 1.55).

Conclusions—
ST-segment morphology variants associated with ER separates subjects with and without an increased risk of arrhythmic death in middle-aged subjects. Rapidly ascending ST segments after the J-point, the dominant ST pattern in healthy athletes, seems to be a benign variant of ER.
Birth Weight Predicts Risk of Cardiovascular Disease Within Dizygotic but Not Monozygotic Twin Pairs
Authors: Öberg Sara , Cnattingius Sven , Sandin Sven , Lichtenstein Paul , Iliadou Anastasia N. 
Published: June 2011

Background—
The widely reported inverse association between birth weight and risk of cardiovascular disease (CVD) has sparked theories about early life determinants of adult disease. Within-twin-pair analysis provides a unique opportunity to investigate whether factors shared within twin pairs influence the association.

Methods and Results—
In a population-based cohort of like-sexed twins with known zygosity born in Sweden from 1926 to 1958, disease-discordant twin pairs were identified through linkage to the National Inpatient and Cause of Death registers between 1973 and 2006. Co-twin–control analyses were performed on twins discordant for cardiovascular disease (n=3884), coronary heart disease (n=2668), and stroke (n=1372). Overall, inverse associations between birth weight and risk of cardiovascular diseases were seen within dizygotic but not monozygotic twin pairs. In dizygotic twins, the odds ratios for a 1-kg within-pair increase in birth weight were 0.74 (95% confidence interval, 0.56 to 0.98) for coronary heart disease and 0.57 (95% confidence interval, 0.37 to 0.88) for stroke. Conversely, no statistically significant associations were found within monozygotic twins (for coronary heart disease: odds ratio, 1.10; 95% confidence interval, 0.73 to 1.68; for stroke: odds ratio, 0.92; 95% confidence interval, 0.48 to 1.80).

Conclusions—
We found an association between birth weight and risk of cardiovascular disease within disease-discordant dizygotic but not monozygotic twin pairs. This indicates that the association between birth weight and cardiovascular disease could be a result of common causes, and that factors that vary within dizygotic but not monozygotic twin pairs may help identify them.
Singular Vectors for Tropical Cyclone–Like Vortices in a Nondivergent Barotropic Framework
Authors: Yamaguchi Munehiko , Nolan David S. , Iskandarani Mohamed , Majumdar Sharanya J. , Peng Melinda S. , Reynolds Carolyn A. 
Published: June 2011

Abstract
In this study, singular vectors (SVs) are calculated for tropical cyclone (TC)–like vortices on an f plane and β plane using a barotropic model, and the structure and time evolution of the SVs are investigated. In the f-plane study, SVs are calculated for TC-like vortices that do and do not satisfy a necessary condition of barotropic instability of normal modes, in which the vorticity gradient changes sign. It is found that, in the case where the initial vortices do not meet the condition, 1) the SVs are tilted against the shear of the background angular velocity as found earlier by Nolan and Farrell, indicating the growth of SVs through the Orr mechanism; 2) the leading singular value increases with the maximum tangential wind speed Vmax and decreases with the radius of the maximum wind (RMW); and 3) the locations of SVs move outward with increasing RMW, Vmax, and the optimization time. In the case where the initial vortex allows for barotropic instability, the SV is initially tilted against the background shear and exhibits transient growth for a limited period. At a certain time during the initial growth, the SV “locks in” to a normal mode structure and remains in that structure so that it may grow exponentially with time.
In contrast to the SVs on an f plane, the azimuthal distribution of the SVs on a β plane becomes more asymmetric, and the extent of the asymmetry increases as the strength of the beta gyres increases. On the β plane, all first and second SVs calculated in this study have an azimuthal wavenumber-1 structure at the optimization time, regardless of whether the vorticity gradient of initial TC-like vortices changes sign and the TC-like vortices include the beta gyres at initial time. It is found that when the first and second SVs are used as ensemble initial perturbations, the linear combination of the initial first and second SVs can shift the vortex toward any direction at the optimization time. This is true even when SVs with a low horizontal resolution are used as initial perturbations, as in the European Centre for Medium-Range Weather Forecasts (ECMWF) and Japan Meteorological Agency (JMA) ensemble prediction system. Such wavenumber-1 perturbations could be useful for generating sufficient spread among the tropical cyclone tracks in ensemble forecasts.
Extreme Cold Winter Temperatures in Europe under the Influence of North Atlantic Atmospheric Blocking
Authors: Sillmann Jana , Croci-Maspoli Mischa , Kallache Malaak , Katz Richard W. 
Published: June 2011

Abstract
North Atlantic atmospheric blocking conditions explain part of the winter climate variability in Europe, being associated with anomalous cold winter temperatures. In this study, the generalized extreme value (GEV) distribution is fitted to monthly minima of European winter 6-hourly minimum temperatures from the ECHAM5/MPI-OM global climate model simulations and the ECMWF reanalysis product known as ERA-40, with an indicator for atmospheric blocking conditions being used as covariate. It is demonstrated that relating the location and scale parameter of the GEV distribution to atmospheric blocking improves the fit to extreme minimum temperatures in large areas of Europe. The climate model simulations agree reasonably with ERA-40 in the present climate (1961–2000). Under the influence of atmospheric blocking, a decrease in the 0.95th quantiles of extreme minimum temperatures can be distinguished. This cooling effect of atmospheric blocking is, however, diminished in future climate simulations because of a shift in blocking location, and thus reduces the chances of very cold winters in northeastern parts of Europe.
Response of the Indian Ocean Basin Mode and Its Capacitor Effect to Global Warming*
Authors: Zheng Xiao-Tong , Xie Shang-Ping , Liu Qinyu 
Published: June 2011

Abstract
The development of the Indian Ocean basin (IOB) mode and its change under global warming are investigated using a pair of integrations with the Geophysical Fluid Dynamics Laboratory Climate Model version 2.1 (CM2.1). In the simulation under constant climate forcing, the El Niño–induced warming over the tropical Indian Ocean (TIO) and its capacitor effect on summer northwest Pacific climate are reproduced realistically. In the simulation forced by increased greenhouse gas concentrations, the IOB mode and its summer capacitor effect are enhanced in persistence following El Niño, even though the ENSO itself weakens in response to global warming. In the prior spring, an antisymmetric pattern of rainfall–wind anomalies and the meridional SST gradient across the equator strengthen via increased wind–evaporation–sea surface temperature (WES) feedback. ENSO decays slightly faster in global warming. During the summer following El Niño decay, the resultant decrease in equatorial Pacific SST strengthens the SST contrast with the enhanced TIO warming, increasing the sea level pressure gradient and intensifying the anomalous anticyclone over the northwest Pacific. The easterly wind anomalies associated with the northwest Pacific anticyclone in turn sustain the SST warming over the north Indian Ocean and South China Sea. Thus, the increased TIO capacitor effect is due to enhanced air–sea interaction over the TIO and with the western Pacific. The implications for the observed intensification of the IOB mode and its capacitor effect after the 1970s are discussed.
A Bayesian Forecast Model of Australian Region Tropical Cyclone Formation
Authors: Werner Angelika , Holbrook Neil J. 
Published: June 2011

AbstractA new and potentially skillful seasonal forecast model of tropical cyclone formation [tropical cyclogenesis (TCG)] is developed for the Australian region. The model is based on Poisson regression using the Bayesian approach. Predictor combinations are chosen using a step-by-step predictor selection. The three-predictor model based on derived indices of June–August average convective available potential energy, May–July average meridional winds at 850 hPa (V850), and July–September geopotential height at 500 hPa produces the smallest standard error (se = 0.36) and root-mean-squared error (RMSE = 5.20) for the leave-one-out cross-validated TCG hindcasts over the 40-yr record between 1968/69–2007/08. The corresponding correlation coefficient between observed annual TCG totals and cross-validated model hindcasts is r = 0.73. Using fourfold cross validation, model hindcast skill is robust, with 85% of the observed seasonal TCG totals hindcast within the model standard deviations. Seasonal TCG totals during ENSO events are typically well captured with RMSE = 5.14 during El Niño, and RMSE = 6.04 during La Niña years. The model is shown to be valuable in hindcasting seasonal TCG totals in the eastern Australian subregion (r = 0.73) and also provides some skill for the western Australian region (r = 0.42), while it not useful for the northern region. In summary, the authors find that the three-predictor Bayesian model provides substantial improvement over existing statistical TCG forecast models, with remarkably skillful hindcasts (forecasts) of Australian region and subregional seasonal TCG totals provided one month ahead of the TC season.
Development of a Unified Land Model for Prediction of Surface Hydrology and Land–Atmosphere Interactions
Authors: Livneh Ben , Restrepo Pedro J. , Lettenmaier Dennis P. 
Published: June 2011

AbstractA unified land model (ULM) is described that combines the surface flux parameterizations in the Noah land surface model (used in most of NOAA’s coupled weather and climate models) with the Sacramento Soil Moisture Accounting model (Sac; used for hydrologic prediction within the National Weather Service). The motivation was to develop a model that has a history of strong hydrologic performance while having the ability to be run in the coupled land–atmosphere environment. ULM takes the vegetation, snow model, frozen soil, and evapotranspiration schemes from Noah and merges them with the soil moisture accounting scheme from Sac. ULM surface fluxes, soil moisture, and streamflow simulations were evaluated through comparisons with observations from the Ameriflux (surface flux), Illinois Climate Network (soil moisture), and Model Parameter Estimation Experiment (MOPEX; streamflow) datasets. Initially, a priori parameters from Sac and Noah were used, which resulted in ULM surface flux simulations that were comparable to those produced by Noah (Sac does not predict surface energy fluxes). ULM with the a priori parameters had streamflow simulation skill that was generally similar to Sac’s, although it was slightly better (worse) for wetter (more arid) basins. ULM model performance using a set of parameters identified via a Monte Carlo search procedure lead to substantial improvements relative to the a priori parameters. A scheme for transfer of parameters from streamflow simulations to nearby flux and soil moisture measurement points was also evaluated; this approach did not yield conclusive improvements relative to the a priori parameters.
Rainfall Retrieval and Nowcasting Based on Multispectral Satellite Images. Part II: Retrieval Study on Daytime Half-Hour Rain Rate
Authors: Yu Fan , Zhuge Xiao-Yong , Zhang Cheng-Wei 
Published: June 2011

AbstractTo implement continuous and reliable rainfall retrieval, based on the satellite retrieval algorithm of 10-min rain rate, this study proposes an immediate tracking and continuous accumulation technique (ITCAT) of half-hour rainfall retrieval by further combining the cross-correlation method. The ITCAT includes two steps. 1) The cross-correlation method is applied to track cloud-motion currents and establish 10-min-interval image sequences. 2) A continuous retrieval of 10-min rain rates is conducted with the image sequences, and finally a total half-hour rainfall is determined by accumulations. The satellite retrieval tests on the typical precipitation processes in the summer of 2008 show that, compared with the previous direct rainfall retrieval for half-hour to one-hour, this rainfall retrieval technique significantly improves the retrieval accuracy of rainfall scope and rainfall intensity ranging from slight rain to rainstorm for both real-time monitoring or nowcasting processes. This technique is more effective than the previous algorithm, and the fundamental reason lies in its consideration of the movement of cloud clusters. On this basis, coverage duration of rainfall clouds can be reliably estimated. It is of significance to the retrieval of deep convective cloud rainfall with rapid movement speed and drastic intensity variation. This technique also provides a feasible idea for improving the accuracy of rainfall nowcasting.
The Impact of Open Oceanic Processes on the Antarctic Bottom Water Outflows
Authors: Kida Shinichiro 
Published: June 2011

Abstract
The impact of open oceanic processes on the Antarctic Bottom Water (AABW) outflows is investigated using a numerical model with a focus on outflows that occur through deep channels. A major branch of the AABW outflow is known to occur as an overflow from the Filchner Depression to the Weddell Sea through a deep channel a few hundred kilometers wide and a sill roughly 500 m deep. When this overflow enters the Weddell Sea, it encounters the Antarctic Slope Front (ASF) at the shelf break, a density front commonly found along the Antarctic continental shelf break. The presence of an AABW outflow and the ASF create a v-shaped isopycnal structure across the shelf break, indicating an interaction between the overflow and oceanic processes. Model experiments show the overflow transport to increase significantly when an oceanic wind stress increases the depth of the ASF. This enhancement of overflow transport occurs because the channel walls allow a pressure gradient in the along-slope direction to exist and the overflow transport is geostrophically controlled with its ambient oceanic water at the shelf break. Because the ASF is associated with a lighter water mass that reaches the depth close to that of the channel, an increase in its depth increases the density gradient across the shelf break and therefore the geostrophic overflow transport. The enhancement of overflow transport is also likely to result in a lighter overflow water mass, although such an adjustment of density likely occurs on a much longer time scale than the adjustment of transport.
Factors associated with higher risks of emergency compulsory admission for immigrants: A report from the ASAP study
Authors: van der Post Louk , Visch Irene , Mulder Cornelis , Schoevers Robert , Dekker Jack , Beekman Aartjan 
Published: June 2011

Objective: Specific ethnic groups appear to be disproportionally represented in emergency compulsory admissions. This may be due to a parallel higher risk of psychopathology, but different pathways to care in patients from ethnic minorities may also be an explanatory factor. In this article we concentrate on the influence of ethnic background, pathways to psychiatric emergency services and the amount of past psychiatric treatment as predictors of emergency compulsory admission. Methods: All the patients coming into contact consecutively with the Psychiatric Emergency Service Amsterdam (PESA) from September 2004 to September 2006 were included in the study. We collected socio-demographic and clinical characteristics, and data about prior use of mental health services and referral to the emergency service. Results: The risk of compulsory admission for immigrants from Surinam and the Dutch Antilles (OR 2.6), sub-Saharan Africa (OR 3.1), Morocco and other non-Western countries (each OR 1.7) was significantly higher than for native Dutch people. After controlling for socio-demographic characteristics, diagnosis, referral pattern and psychiatric treatment history, this correlation was no longer found. Conclusion: We found no evidence to substantiate the hypothesis that ethnic background plays an independent role in emergency compulsory admission. Police referral rather than referral by a GP, and being diagnosed with a psychosis, seemed to be explanatory factors for the high risk of compulsory admission for non-Western immigrants. Infrequent contact with secondary mental healthcare during the previous five years was not found to be consistently associated with a higher risk.