bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Preparation and Some Reactions of the Tungsten Hydridotosylato Complex Cp2WH(OTs).
Authors: MINATO M. , TOMITA H. , REN J.‐G. , ITO T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Routes to Pyranosidic Homologated Conjugated Enals and Dienes from Monosaccharides.
Authors: LOPEZ J. C. , LAMEIGNERE E. , BURNOUF C. , LABORDE M. A. , GHINI A. A. , OLESKER A. , LUCACS G. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Orally Active Cephalosporins. Part 1. Synthesis and Structure‐Activity Relationships of 7β‐(2‐(R)‐Amino‐2‐phenylacetamido)‐3‐(1H‐1,2,3‐ triazol‐4‐yl)alkylthiomethyl ‐3‐cephem‐4‐carboxylic Acid and Related Compounds
Authors: KUME M. , KUBOTA T. , KIMURA Y. , NAKASHIMIZU H. , MOTOKAWA K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (3,3)Sigmatropic Ring Expansion of Cyclic Thionocarbonates. Part 9. Total Synthesis of (.+‐.)‐Yellow Scale Pheromone via 10‐Membered Thiolcarbonate.
Authors: HARUSAWA S. , TAKEMURA S. , OSAKI H. , YONEDA R. , KURIHARA T. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mercury Elimination from Gaseous Streams.
Authors: DAZA L. , MENDIOROZ S. , PAJARES J. A. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Versatile Roles of Lewis Acids in the Reactions of Allylic Tin Compounds
Authors: NISHIGAICHI Y. , TAKUWA A. , NARUTA Y. , MARUYAMA K. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Functionalized Z‐Olefins Using 1,1‐Dimetalloalkanes.
Authors: TUCKER C. E. , KNOCHEL P. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Some New Fused Heterocycles Containing a Bridgehead Nitrogen Atom under PTC Conditions. A New Application of Cyanoketene S, S‐Acetals.
Authors: EL‐SHAFEI A. K. , SOLIMAN A. M. , SULTAN A. A.‐R. , EL‐SAGHIER A. M. M. 
Published: September 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Understanding the Key Factors that Control the Inhibition of Type II Dehydroquinase by (2R)‐2‐Benzyl‐3‐dehydroquinic Acids
Authors: Peón Antonio , Otero José M. , Tizón Lorena , Prazeres Verónica F. V. , Llamas‐Saiz Antonio L. , Fox Gavin C. , van Raaij Mark J. , Lamb Heather , Hawkins Alastair R. , Gago Federico , Castedo Luis , González‐Bello Concepción 
Published: September 2010

AbstractThe binding mode of several substrate analogues, (2R)‐2‐benzyl‐3‐dehydroquinic acids 4, which are potent reversible competitive inhibitors of type II dehydroquinase (DHQ2), the third enzyme of the shikimic acid pathway, has been investigated by structural and computational studies. The crystal structures of Mycobacterium tuberculosis and Helicobacter pylori DHQ2 in complex with one of the most potent inhibitor, p‐methoxybenzyl derivative 4 a, have been solved at 2.40 Å and 2.75 Å, respectively. This has allowed the resolution of the M. tuberculosis DHQ2 loop containing residues 20–25 for the first time. These structures show the key interactions of the aromatic ring in the active site of both enzymes and additionally reveal an important change in the conformation and flexibility of the loop that closes over substrate binding. The loop conformation and the binding mode of compounds 4 b–d has been also studied by molecular dynamics simulations, which suggest that the benzyl group of inhibitors 4 prevent appropriate orientation of the catalytic tyrosine of the loop for proton abstraction and disrupts its basicity.
Current advances in the non‐chromatographic fractionation and characterization of PEGylated proteins
Authors: Mayolo‐Deloisa Karla , González‐Valdez José , Guajardo‐Flores Daniel , Aguilar Oscar , Benavides Jorge , Rito‐Palomares Marco 
Published: September 2010

AbstractFor more than 30 years, PEGylation has been used to improve the physicochemical properties of several proteins and therapeutic drugs having a major impact in the biopharmaceutical industry. The purification of PEGylated proteins usually involves two basic challenges: (1) the separation of PEG‐proteins from other reaction products; and (2) the sub‐fractionation of PEG‐proteins on the basis of their degree of PEGylation and positional isomerism. Currently, most PEGylated protein purification processes are based on chromatographic techniques, especially size exclusion chromatography (SEC) and ion exchange chromatography (IEX). Nonetheless, other less frequently used strategies based on non‐chromatographic techniques such as ultrafiltration, electrophoresis, capillary electrophoresis, and aqueous two‐phase systems have been developed in order to fractionate and analyze PEGylated derivates. This review presents current advances in some of the most widely used non‐chromatographic strategies for the fractionation and analysis of PEG‐protein conjugates. Copyright © 2010 Society of Chemical Industry
Electron predators are hydrogen atom traps. Effects of aryl groups on N—Cα bond dissociations of peptide radicals
Authors: Tureček František 
Published: September 2010

AbstractEffects of substituted aryl groups on dissociations of peptide aminoketyl radicals were studied computationally for model tetrapeptide intermediates GXD•G where X was a cysteine residue that was derivatized by S‐(3‐nitrobenzyl), S‐(3‐cyanobenzyl), S‐(3,5‐dicyanobenzyl), S‐(2,3,4,5,6‐pentafluorobenzyl), and S‐benzyl groups. The aminoketyl radical was placed within the Asp amide group. Aminoketyl radicals having the S‐(3‐nitrobenzyl) group were found to undergo spontaneous and highly exothermic migration of the hydroxyl hydrogen atom onto the nitro group in conformers allowing interaction between these groups. Competing reaction channels were investigated for aminoketyl radicals having the S‐(3‐cyanobenzyl) and S‐(3,5‐dicyanobenzyl) groups, e.g. H‐atom migration to the C and N atoms of the C≡N group, migration to the C‐4 position of the phenyl ring, and dissociation of the radical‐activated NCα bond between the Asp and Gly residues. RRKM kinetic analysis on the combined B3LYP and ROMP2/6‐311++G(2d,p) potential energy surface indicated > 99% H‐atom transfer to the C≡N group forming a stable iminyl intermediate. The NCα bond dissociation was negligible. In contrast, peptides with the S‐(2,3,4,5,6‐pentafluorobenzyl) and S‐benzyl groups showed preferential NCα bond dissociation that outcompeted H‐atom migration to the C‐4 position and fluorine substituents in the phenyl ring. These computational results are used to suggest an alternative mechanism for the quenching effect on electron‐based peptide backbone dissociations of benzyl groups with electron‐withdrawing substitutents, as reported recently. Copyright © 2010 John Wiley & Sons, Ltd.
Non‐destructive testing methods for determining the age‐hardening condition of aluminium alloys using the alloy EN AW‐6082 as an example
Authors: Grittner N. , Bormann D. , Springer R. , Reimche W. , Bach Fr.‐W. 
Published: September 2010

AbstractWarmauslagerungsfähige Aluminiumlegierungen bieten den Vorteil, dass sie in ihrer Festigkeit in einem sehr weiten Bereich gezielt eingestellt werden können. Dies setzt voraus, dass die Prozesstemperaturen und ‐zeiten der Warmauslagerung sehr genau eingehalten werden. Die hier vorgestellten Arbeiten zielen auf die Qualifizierung zerstörungsfreier Messmethoden ab, mit denen der Warmauslagerungszustand Prozessbegleitend sehr schnell ermittelt werden kann. Somit können bereits während der Durchführung der Warmauslagerung Fehler im Prozess detektiert werden und im Sinne der Qualitätssicherung eine Verbesserung der Kontrollmechanismen erzielt werden. Die Untersuchungen wurden mittels Leitfähigkeits‐, Wirbelstrom‐ und Resonanz‐Frequenz‐Messungen durchgeführt. Insbesondere die Ergebnisse der Wirbelstrom‐ und Resonanz‐Frequenz‐Messungen lassen das hohe Potenzial zerstörungsfrei arbeitender Verfahren zur online Kontrolle des Warmauslagerungszustandes erkennen.Heat treatable aluminium alloys offer the advantage that their strength can be specifically adjusted within a very broad range. This presupposes that the age‐hardening's process temperatures and durations are very precisely maintained. The work presented here aims to qualify non‐destructive testing methods with which the age‐hardening condition can be very rapidly determined during the actual process. Thus, process defects can be readily detected during the age‐hardening procedure and, within the scope of a quality assurance, an improvement of the control mechanisms can be obtained. The investigations were carried out by means of conductivity, eddy‐current and resonance‐frequency measurements. The results of the eddy‐current and resonance‐frequency measurements in particular allow the enormous potential of non‐destructive procedures to be realised for the online control of the age‐hardening condition.
Analysis of early events in the interaction between Fusarium graminearum and the susceptible barley (Hordeum vulgare) cultivar Scarlett
Authors: Yang Fen , Jensen Jens D. , Svensson Birte , Jørgensen Hans J.L. , Collinge David B. , Finnie Christine 
Published: September 2010

AbstractA proteomic analysis was conducted to map the events during the initial stages of the interaction between the fungal pathogen Fusarium graminearum and the susceptible barley cultivar Scarlett. Quantification of fungal DNA demonstrated a sharp increase in fungal biomass in barley spikelets at 3 days after inoculation. This coincided with the appearance of discrete F. graminearum‐induced proteolytic fragments of β‐amylase. Based on these results, analysis of grain proteome changes prior to extensive proteolysis enabled identification of barley proteins responding early to infection by the fungus. In total, the intensity of 51 protein spots was significantly changed in F. graminearum‐infected spikelets and all but one were identified. These included pathogenesis‐related proteins, proteins involved in energy metabolism, secondary metabolism and protein synthesis. A single fungal protein of unknown function was identified. Quantitative real‐time RT‐PCR analysis of selected genes showed a correlation between high gene expression and detection of the corresponding proteins. Fungal genes encoding alkaline protease and endothiapepsin were expressed during 1–3 days after inoculation, making them candidates for generation of the observed β‐amylase fragments. These fragments have potential to be developed as proteome‐level markers for fungal infection that are also informative about grain protein quality.
Prevalence of anxiety in patients awaiting diagnostic procedures in an oncology center in Brazil
Authors: Yu L. S. , Chojniak R. , Borba M. A. , Girão D. S. , Lourenço M. T. D. P. C. 
Published: September 2010

AbstractObjective: Anxiety disorders have been shown to undermine the quality of life of cancer patients. Unfortunately, medical professionals often neglect to screen for anxiety in their patients. The aim of the present study was to describe the prevalence of anxiety in patients awaiting diagnostic procedures in an oncology center waiting room, and to investigate possible relationships between anxiety and demographic and clinical variables.Methods: A cross‐sectional study was performed with 398 patients who completed a self‐administered questionnaire containing the Hospital Anxiety and Depression Scale (HADS) and the State‐Trait Anxiety Inventory (STAI).Results: Results of the HADS indicated that 38% of participants had anxiety, while data from the STAI showed that 46% had either high state or trait anxiety. The most frequently cited source of anxiety was concern over test results. Age, gender, employment status, and education level were correlated with anxiety.Conclusions: The prevalence of anxiety is high among patients awaiting diagnostic procedures. Patients in the waiting room should be routinely screened for anxiety. Careful assessment and treatment of anxiety are important components in the care of patients with cancer. Copyright © 2010 John Wiley & Sons, Ltd.
Effect of environment on ultrafast photoexcitation kinetics in single‐wall carbon nanotubes
Authors: Obraztsova Ekaterina A. , Lüer Larry , Obraztsova Elena D. , Chernov Alexander I. , Brida Daniele , Polli Dario , Lanzani Guglielmo 
Published: September 2010

AbstractRecently, nonlinear optical properties of single‐wall carbon nanotubes (SWNT) have attracted a great interest. This material has been proven to be an efficient wide spectral range saturable absorber. However, up to now it is unclear what are the optimum sample preparation parameters and operational spectral range. In this work, we have applied femtosecond pump–probe spectroscopy to investigate photoexcitation kinetics in SWNTs depending on the sample preparation technique. We demonstrate here that the characteristic lifetimes of the saturable absorption in SWNT samples decrease with increasing interaction of SWNTs with each other and with the surrounding environment. We also show that the saturable absorption is fairly strong not only for the energies corresponding to the first electronic transition, but also for transitions at higher energies. We conjecture the contribution of energy and charge transfer to the observed ultrafast dynamics. Charge transfer is evidenced by a photo‐induced enhancement of the Sommerfeld factor.
Substrate reduction therapy with miglustat in chronic GM2 gangliosidosis type Sandhoff: results of a 3‐year follow‐up
Authors: Masciullo Marcella , Santoro Massimo , Modoni Anna , Ricci Enzo , Guitton Jerome , Tonali Pietro , Silvestri Gabriella 
Published: September 2010

AbstractGM2 gangliosidosis type Sandhoff is caused by a defect of beta‐hexosaminidase, an enzyme involved in the catabolism of gangliosides. It has been proposed that substrate reduction therapy using N‐butyl‐deoxynojirimycin (miglustat) may delay neurological progression, at least in late‐onset forms of GM2 gangliosidosis. We report the results of a 3‐year treatment with miglustat (100 mg t.i.d) in a patient with chronic Sandhoff disease manifesting with an atypical, spinal muscular atrophy phenotype. The follow‐up included serial neurological examinations, blood tests, abdominal ultrasound, and neurophysiologic, cognitive, brain, and muscle MRI studies. We document some minor effects on neurological progression in chronic Sandhoff disease by miglustat treatment, confirming the necessity of phase II therapeutic trials including early‐stage patients in order to assess its putative efficacy in chronic Sandhoff disease.
Selection on ram 18-month weight to improve lamb growth rate
Authors: Croston D. , Read J. L. , Jones D. W. , Steane D. E. , Smith C. 
Published: September 2010

ABSTRACTThirteen pairs of Suffolk rams were selected on high and low 18-month adjusted live weight from six farms over 2 years, to establish the relationship between 18-month weight and early lamb growth. Progeny were first produced in recorded crossbred flocks (618 lambs) and then in an experimental flock of crossbred ewes (1083 lambs). Different results were obtained from the recorded and experimental flocks. The regressions of lamb 12- to 13-week weight on ram 18-month weight (within farm deviation) were 0·053 ± 0·022 kg and –0·004 ± 0·020 kg, respectively. These regressions for indirect selection correspond to ‘effective’ heritabilities for direct selection for lamb growth of 0·18 ± 0·07 and 0·02 ± 0·06 respectively. Improvement of early Iamb growth is discussed and it is concluded that selection for 18-month weight is unlikely to be a useful method.
The effect of proportion of cell-wall material from lucerne leaf meal on apparent digestibility, rate of passage and gut characteristics in pigs
Authors: Kuan K. K. , Stanogias G. , Dunkin A. C. 
Published: September 2010

ABSTRACTMetabolism trials were conducted with entire male pigs (average initial weight 44·4 ± 0·2 kg) to determine the apparent digestibility of the major chemical components of diets containing 0·05, 0·10, 0·15 and 0·20 cell-wall material (determined as neutral detergent fibre) from lucerne leaf meal, when added to a constant daily allowance of a semi-synthetic basal diet. Concurrent rate of passage studies were also carried out.Increasing the proportion of cell-wall material in the diet resulted in a linear decrease in the apparent digestibility of dry matter, crude protein and ether extract and the apparent digestibility and metabolizability of gross energy. Daily nitrogen retention (g) increased linearly with an increasing proportion of cell-wall material in the diet. Coefficients of apparent digestibility and cell-wall material fractions did not differ significantly with changes in the dietary proportions.Although the rate of passage of digesta was slower (F < 0·001) in animals fed the diets containing 0·05 and 0·10 cell-wall material than in those fed the two diets with higher proportions, it did not appear to be a major factor contributing to the observed decline in the apparent digestibility of dietary chemical components as the proportion was raised.Increase in dietary proportion of cell wall material was associated with marked linear increase in weight and/or length of various segments of the gastro-intestinal tract.
A preliminary study of the effects of the anthelmintic thiophanate (‘Nemafax’) on the breeding performance of sows naturally infested with Oesophagostomum spp
Authors: Baines D. M. , Lake P. 
Published: September 2010

ABSTRACTThree trials were conducted on commercial premises using sows naturally infested with gastro-intestinal nematodes, primarily Oesophagostomum spp. In two trials the farrowing performance of sows treated approximately 7 days before farrowing with thiophanate (‘Nemafax’) in-feed at a median dosage of 62·5 mg/kg was compared with that of untreated controls. In the third trial a similar comparison was made between sows treated approximately 7 days before expected service and untreated controls. In all cases faecal egg counts indicated thiophanate was highly effective against the nematode burdens present. Administered pre-farrowing, thiophanate resulted in better pre-weaning weight gains and relatively lower creep feed consumptions of the piglets. This effect was most marked in the trial with a higher level of Oesophagostomum spp. infestation in the sows. Under similar circumstances, pre-service medication produced a response in terms of live piglets born and those surviving to weaning.
A note on the carcass quality of Dairy Shorthorn, Red Friesian, Red Holstein, Danish Red, Meuse-Rhine-Yssel, Simmental and North Devon progeny of Dairy Shorthorn dams
Authors: Hocking P. M. 
Published: September 2010

ABSTRACTCarcass characteristics of 246 bulls and steers by Dairy Shorthorn (DS), Red Friesian (RF), Red Holstein (RH), Danish Red (DR), Meuse-Rhine-Yssel (MR), Simmental (SM) and North Devon (BB) bulls were recorded as part of a breed improvement programme. Carcasses of animals on grass-feeding systems were older, had lower fat and conformation scores and higher estimated lean yield than on intensive cereal systems, BB were fatter, and MR and SM leaner, than the remaining breed groups which were similar to DS and SM progeny had high conformation scores. Estimated lean in the live weight (g/kg) relative to DS was RF +5, RH −3, DR +5, MR +16, SM +16 and BB +6 with an average standard error of 3.
A note on the optimum level of roughage inclusion in the diet of the early-weaned calf
Authors: Thomas Delana B. , Hinks C. E. 
Published: September 2010

ABSTRACTForty purchased male Hereford ♂ × Friesian ♀ calves (about 14 days old) were offered concentrate diets containing 0, 170, 230 or 320 g chopped (20 mm) straw per kg. Food intake and live-weight gains of calves were increased by the inclusion of straw, but the 320 g straw treatment tended to depress intake and gain. The optimum concentration of fibre for maximizing live-weight gains was 150 g trichloracetic acid fibre per kg of diet (220 g chopped straw per kg).
A note on the possible use of goats in hill sheep grazing systems
Authors: Russel A. J. F. , Maxwell T. J. , Bolton G. R. , Currie D. C. , White I. R. 
Published: September 2010

ABSTRACTA pilot study was conducted to investigate the possibility of using goats to manipulate the amount and composition of indigenous and improved vegetation on hill land in the west of Scotland.Two vegetationally similar plots, each of approximately 0·6 ha, were used. Approximately 0·45 of each plot comprised sown ryegrass-clover pasture, the remainder being indigenous vegetation (principally Calluna vulgaris, Eriophorum and Tricophorum spp. with some Deschampsia, Molinia and Carex spp.). One plot was stocked with 14 yearling Anglo-Nubian goats and the other with seven mature Blackface sheep, the total weight of livestock on the two plots being the same (500 kg).On the reseeded areas the proportions (± s.e. of difference) of ryegrass grazed by sheep and goats after 2, 5 and 8 weeks were 0·65 and 0·11 (0·075), 0·68 and 0·42 (0·112), and 0·77 and 0·58 (0·149), respectively; corresponding values for proportional clover cover were 016 and 0·45 (0·071), 0·16 and 0·38 (0·070), and 0·10 and 0·35 (0·070), respectively. The goats also actively grazed clumps of Juncus spp. and invading indigenous species which were not eaten by sheep.On the indigenous areas the sheep grazed a higher proportion of Calluna than did goats (0·08 and 0·05) but grazed less E. vaginatum (0·07 and 0·13), E. angustifolium (0·04 and 0·11), and other indigenous species (0·21 and 0·36), respectively. The degree of utilization of grazed indigenous species by goats was also greater than that by sheep for all species except Calluna.The results suggest that goats may have a use in some sheep production systems as an aid to the management of the varied plant communities of hill land, and particularly in the maintenance and further improvement of reseeded pastures.