bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late diagnosis of sitosterolemia in an adult case with unexplained hemolytic anemia
Authors: Jurado Tapiador Rebeca , González P. , Hernandez‐Rodriguez I. 
Published: May 2024

AbstractSitosterolemia is a rare autosomal recessive disease that lead to an increase in the intestinal absorption and decreased biliary excretion plant sterols. It is caused by mutations in ABCG5 and ABCG8 genes, encoring sterolin‐1 and sterolin‐2 protein. The main clinical manifestations are xanthomas, premature atherosclerosis, arthralgia and, of note, hematological alterations. As in many other systemic diseases, hematological manifestations may be the only notable finding, for this reason we want to highlight the importance of multidisciplinary work and raise awareness of this rare disease that can lead to serious consequences if not treated prematurely. Here we present a case of this disease as well as its entire diagnostic process developed from a simple analytical alteration.
DNA methylase 1 influences temperature responses and development in the invasive pest Tuta absoluta
Authors: Tang Yanhong , Zhang Huifang , Zhu Huanqing , Bi Siyan , Wang Xiaodi , Ji Shunxia , Ji Jianhang , Ma Dongfang , Huang Cong , Zhang Guifen , Yang Nianwan , Wan Fanghao , Lü Zhichuang , Liu Wanxue 
Published: May 2024

AbstractDNA methylase 1 (Dnmt1) is an important regulatory factor associated with biochemical signals required for insect development. It responds to changes in the environment and triggers phenotypic plasticity. Meanwhile, Tuta absoluta Meyrick (Lepidoptera: Gelechiidae)—a destructive invasive pest—can rapidly invade and adapt to different habitats; however, the role of Dnmt1 in this organism has not been elucidated. Accordingly, this study investigates the mechanism(s) underlying the rapid adaptation of Tuta absoluta to temperature stress. Potential regulatory genes were screened via RNAi (RNA interference), and the DNA methylase in Tuta absoluta was cloned by RACE (Rapid amplification of cDNA ends). TaDnmt1 was identified as a potential regulatory gene via bioinformatics; its expression was evaluated in response to temperature stress and during different development stages using real‐time polymerase chain reaction. Results revealed that TaDnmt1 participates in hot/cold tolerance, temperature preference and larval development. The full‐length cDNA sequence of TaDnmt1 is 3765 bp and encodes a 1254 kDa protein with typical Dnmt1 node‐conserved structural features and six conserved DNA‐binding active motifs. Moreover, TaDnmt1 expression is significantly altered by temperature stress treatments and within different development stages. Hence, TaDnmt1 likely contributes to temperature responses and organismal development. Furthermore, after treating with double‐stranded RNA and exposing Tuta absoluta to 35°C heat shock or −12°C cold shock for 1 h, the survival rate significantly decreases; the preferred temperature is 2°C lower than that of the control group. In addition, the epidermal segments become enlarged and irregularly folded while the surface dries up. This results in a significant increase in larval mortality (57%) and a decrease in pupation (49.3%) and eclosion (50.9%) rates. Hence, TaDnmt1 contributes to temperature stress responses and temperature perception, as well as organismal growth and development, via DNA methylation regulation. These findings suggest that the rapid geographic expansion of T absoluta has been closely associated with TaDnmt1‐mediated temperature tolerance. This study advances the research on ‘thermos Dnmt’ and provides a potential target for RNAi‐driven regulation of Tuta absoluta.
Toddlers' prior social experience with speakers influences their word learning
Authors: Breitfeld Elise , Compton Anna M. , Saffran Jenny R. 
Published: May 2024

AbstractToddlers prefer to learn from familiar adults, particularly their caregivers, and perform better on word learning tasks when taught by caregivers than by strangers. However, it remains unclear why toddlers learn better from caregivers than from strangers. One possibility is that toddlers are more receptive to learning from individuals whom they have found to be engaging in previous interactions. The current study tested whether toddlers learn more from an unfamiliar adult who was previously engaging than from an unfamiliar adult who was previously unengaging. Toddlers (27–29 months, N = 40) were taught labels for novel objects by two different experimenters. Prior to word learning, toddlers watched pre‐recorded videos of one experimenter utilizing engaging behaviors (i.e., using infant‐directed speech, gestures, eye contact, and positive affect) and one experimenter utilizing unengaging behaviors (i.e., using adult‐directed speech, no gestures, no eye contact, and neutral affect). Both experimenters were equally engaging during labeling. Word learning was then tested using a looking‐while‐listening paradigm. The results of linear mixed‐effects model, cluster‐based permutation, and growth curve analyses suggest heightened performance for words that were taught by the experimenter who was previously engaging. These results begin to reveal the kinds of social experiences that promote success in early word learning.
Acupressure, a promising intervention for fatigue, within the European nursing care pathways (ENP): An integrative review
Authors: Jiang‐Siebert Qiumei , Wieteck Pia , Kraus Sebastian 
Published: May 2024

AbstractAimsThe aim of this study is to test whether acupressure for patients with fatigue is an efficient nursing intervention and if it can be implemented into the European nursing care pathways (ENP) nursing classification system.BackgroundPreviously, interventions for acupressure were included nonspecifically in ENP and therefore were not available for standardized nursing documentation in an electronic health record (EHR).IntroductionAcupressure is a nursing intervention that is increasingly used in specific settings. ENP is a nursing classification system that provides evidence‐based nursing interventions for nursing diagnoses.MethodsA systematic international literature search was conducted from May 2021 to December 2021. An iterative, hierarchical search process according to the 6S evidence pyramid was chosen. The results were reported following the PRISMA statement.ResultsFindings of 49 included publications that studied a total of 1,716 patients indicate that certain acupressure points may be efficient in treating fatigue.DiscussionAcupressure is a useful nursing intervention and can really help patients experiencing fatigue. It is illustrated how the findings have been implemented in the development of ENP nursing interventions to document acupressure.ConclusionThe acupressure points most frequently used on the ear with positive effects in improving fatigue are Shen Men, liver, spleen, subcortex, endocrine, heart, and sympathetic, while the most common points on the body are ST 36, SP 6, LI 4, HT 7, KID 1, Ex‐HN 3, Ex‐HN, and KID 3.Implication for nursingIn the future, nurses will be able to use ENP to quickly and easily document acupressure interventions for fatigue in the EHR.In the EHR, the documentation of the nursing process with ENP could help to promote research into evidence‐based approaches to fatigue by generating mass data on the different concepts of acupressure, which could lead to a clearer determination of the evidence and contribute to the safety of care and patients.
The relationship between governance structure and tourism development in China: Evidence from time and frequency domains
Authors: Raza Syed Ali , Ahmed Maiyra , Irfan Muhammad 
Published: May 2024

AbstractThe purpose of this study is to examine the relationship between governance structure and tourism growth in China. This study examines the worldwide governance indicators’ correlation with tourism development (TD) through the time and frequency approach. The sample used in this study covers the duration from 2002Q1–2019Q4; the connection among the variables under consideration, named corruption control, political stability and absence of violence/terrorism, the rule of law, voice and accountability and regulatory quality, is examined individually with respect to TD. The outcome of the study highlights the considerable importance of governance structure indicators in developing the tourism sector. Moreover, the results verify causal connections among the time‐series of the variables under consideration, pointing towards the dynamic nature of their influence. Based on the results, this study stresses the imperative role of government and authorities in improving the quality of governance. Moreover, governance indicators are crucial for economies as they portray the reputation and image of a country, therefore interesting international tourists and strengthening the tourism sector. Additionally, the results not just emphasize the significance of a strong governance structure but also call for a strategic plan which fosters TD in the upcoming years.
Preparation and investigation of mechanical and electromagnetic wave absorption properties of TiC–TiB2/Si3N4 composites
Authors: Wang Shaoyin , Bi Jianqiang , Liang Guandong , Qiao Linjing , Yang Yao , Wang Hongyi , Liang Shuyong , Rong Jiacheng , Che Chengjiao , Yuan Jilie , Chen Yueguang 
Published: May 2024

AbstractThe aim of achieving integration of lightweight, high strength, high‐temperature resistant, and satisfactory electromagnetic (EM) wave absorption was successfully accomplished in the present study by synthesizing TiC–TiB2 fibers reinforced Si3N4 composites, which were pressureless sintered at 1650°C for 2 h. The preparation of TiC–TiB2 fibers was conducted through a chloride‐assisted carbothermic method. This work focused on investigating the effects of incorporating TiC–TiB2 fibers on the mechanical properties and EM wave absorption characteristics of the composites. The 30 wt% TiC–TiB2/Si3N4 composite displayed the bulk density of 1.89 g/cm3, bending strength of 93.11 ± 3.91 MPa, fracture toughness of 1.81 ± 0.10 MPa m1/2, minimum reflection loss of −38.87 dB, and effective absorption bandwidth of 1.43 GHz in the Ku‐band, respectively. The as‐synthesized TiC–TiB2/Si3N4 composites are promising candidates for EM wave absorbing load‐bearing materials due to their outstanding mechanical properties and microwave absorption properties.
Working on differentiated nursing practices in hospitals: A learning history on enacting new nursing roles
Authors: Martini Dieke , Schalkwijk Hugo , Schoonhoven Lisette , Noordegraaf Mirko , Lalleman Pieterbas 
Published: May 2024

AbstractObjectiveThis study aims to better understand how new future‐oriented nursing roles are enacted in a general hospital.DesignA learning history, that is, a participatory action‐oriented research design to explore and foster organizational learning.MethodsData collection consisted of a (historical) document analysis, the shadowing of differentiated nursing practices (36 h), 22 open interviews, 4 oral history interviews, 2 focus groups and a podcast series (7 h) created with participants.ResultsThe data gathered revealed three important themes regarding enacting new nursing roles: (1) stretching the nature of nursing work, (2) using earlier experiences and (3) collectively tackling taboos.ConclusionsDifferentiated nursing practices and enacting new nursing roles have long and complex histories. Attempts to differentiate are often met with resistance from within the nursing profession. This study shows how the new role of nurse coordinator was negotiated in nursing teams. With a bottom‐up approach focused on collective responsibilities. By acknowledging and reflecting on the past, spaces were enacted in which the role of nurse coordinator became one role, among others, in the delivery of patient care.ImpactThis study provides an innovative perspective on differentiated nursing practices by focusing on the past, the present and the future. We found that local, situated conditions can be taken as starting points when new nursing roles are enacted. In addition, shifting focus from individual nursing roles to nursing team development, emphasizing collective responsibilities, softens strong (historically) grown emotions and creates spaces in which new roles become negotiable.Patient or Public ContributionNo patient or public contribution.
A systematic review with meta‐analysis of heritability estimates for temperament‐related traits in beef and dairy cattle populations
Authors: Pinto Luís Fernando Batista , Medrado Bruno Delphino , Pedrosa Victor Breno , Brito Luiz F. 
Published: May 2024

AbstractTemperament (docility) is a key breeding goal in the cattle industry due to its direct relationship with animal welfare, cattle handler's safety and animal productivity. Over the past six decades, numerous studies have reported heritability estimates for temperament‐related traits in cattle populations ranging from low to high values. Therefore, the primary objective of this study was to perform a comprehensive systematic review with meta‐analysis to obtain weighted estimates of heritability for temperament‐related traits in worldwide cattle populations. After data editing and quality control, 106 studies were included in the systematic review, of which 29.2% and 70.8% reported estimates of heritability for temperament‐related traits in dairy and beef cattle populations, respectively. Meta‐analyses were performed for 95 heritability estimates using a random model approach. The weighted heritability estimates were as follow: (a) flight score at weaning = 0.23 (95% CI: 0.15–0.32); (b) flight speed at weaning = 0.30 (95% CI: 0.26–0.33); (c) joint analysis of flight speed and flight score at weaning = 0.27 (95% CI: 0.22–0.31); (d) flight speed at yearling = 0.26 (95% CI: 0.21–0.30); (e) joint analysis of flight speed at weaning and yearling = 0.27 (95% CI: 0.24–0.30); (f) movement score = 0.12 (95% CI: 0.08–0.15); (g) crush score at weaning = 0.21 (95% CI: 0.17–0.25); (h) pen score at weaning = 0.27 (95% CI: 0.19–0.34); (i) pen score at yearling = 0.20 (95% CI: 0.17–0.23); (j) joint analysis of pen score at weaning and yearling = 0.22 (95% CI: 0.18–0.26); (k) cow's aggressiveness at calving = 0.10 (95% CI: 0.01–0.19); (l) general temperament = 0.13 (95% CI: 0.06–0.19); (m) milking temperament = 0.16 (95% CI: 0.11–0.21); and (n) joint analysis of general and milking temperament = 0.14 (95% CI: 0.11–0.18). The heterogeneity index ranged from 0% to 77%, and the Q‐test was significant (p < 0.05) for four single‐trait meta‐analyses. In conclusion, temperament is moderately heritable in beef cattle populations, and flight speed at weaning had the highest weighted heritability estimate. Moreover, between‐study heterogeneity was low or moderate in beef cattle traits, suggesting reasonable standardization across studies. On the other hand, low‐weighted heritability and high between‐study heterogeneity were estimated for temperament‐related traits in dairy cattle, suggesting that more studies are needed to better understand the genetic inheritance of temperament in dairy cattle populations.
Transgenerational effects of the maternal gestational environment on the post‐natal performance of beef cattle: A reaction norm approach
Authors: Santana Mário Luiz , Bignardi Annaiza Braga , Pereira Rodrigo Junqueira , Sterman Ferraz José Bento , Eler Joanir Pereira 
Published: May 2024

AbstractIn tropical beef cattle production systems, animals are commonly raised on pastures, exposing them to potential stressors. The end of gestation typically overlaps with a dry period characterized by limited food availability. Late gestation is pivotal for fetal development, making it an ideal scenario for inter‐ and transgenerational effects of the maternal gestational environment. Intergenerational effects occur due to exposure during gestation, impacting the development of the embryo and its future germline. Transgenerational effects, however, extend beyond direct exposure to the subsequent generations. The objective of the present study was to verify these effects on the post‐natal performance of zebu beef cattle. We extended the use of a reaction norm model to identify genetic variation in the animals' responses to transgenerational effects. The inter‐ and transgenerational effects were predominantly positive (−0.09% to 19.74%) for growth and reproductive traits, indicating improved animal performance on the phenotypic scale in more favourable maternal gestational environments. Additionally, these effects were more pronounced in the reproductive performance of females. On average, the ratio of direct additive genetic variances of the slope and intercept of the reaction norm ranged from 1.23% to 3.60% for direct and from 10.17% to 11.42% for maternal effects. Despite its relatively modest magnitude, this variation proved sufficient to prompt modifications in parameter estimates. The average percentage variation of direct heritability estimates ranged from 19.3% for scrotal circumference to 33.2% for yearling weight across the environmental descriptors evaluated. Genetic correlations between distant environments for the studied traits were generally high for direct effects and far from unity for maternal effects. Changes in EBV rankings of sires across different gestational environments were also observed. Due to the multifaceted nature of inter‐ and transgenerational effects of the maternal gestational environment on various traits of beef cattle raised under tropical pasture conditions, they should not be overlooked by producers and breeders. There were differences in the specific response of beef cattle to variations in the quality of the maternal gestational environment, which can be partially explained by transgenerational epigenetic inheritance. Adopting a reaction norm model to capture a portion of the additive variance induced by inter‐ or transgenerational effects could be an alternative for future research and animal genetic evaluations.
Is autism a PIN1 deficiency syndrome? A proposed etiological role for glyphosate
Authors: Seneff Stephanie , Kyriakopoulos Anthony M. , Nigh Greg 
Published: May 2024

AbstractAutism is a neurodevelopmental disorder, the prevalence of which has increased dramatically in the United States over the past two decades. It is characterized by stereotyped behaviors and impairments in social interaction and communication. In this paper, we present evidence that autism can be viewed as a PIN1 deficiency syndrome. Peptidyl‐prolyl cis/trans isomerase, NIMA‐Interacting 1 (PIN1) is a peptidyl‐prolyl cis/trans isomerase, and it has widespread influences in biological organisms. Broadly speaking, PIN1 deficiency is linked to many neurodegenerative diseases, whereas PIN1 over‐expression is linked to cancer. Death‐associated protein kinase 1 (DAPK1) strongly inhibits PIN1, and the hormone melatonin inhibits DAPK1. Melatonin deficiency is strongly linked to autism. It has recently been shown that glyphosate exposure to rats inhibits melatonin synthesis as a result of increased glutamate release from glial cells and increased expression of metabotropic glutamate receptors. Glyphosate's inhibition of melatonin leads to a reduction in PIN1 availability in neurons. In this paper, we show that PIN1 deficiency can explain many of the unique morphological features of autism, including increased dendritic spine density, missing or thin corpus callosum, and reduced bone density. We show how PIN1 deficiency disrupts the functioning of powerful high‐level signaling molecules, such as nuclear factor erythroid 2‐related factor 2 (NRF2) and p53. Dysregulation of both of these proteins has been linked to autism. Severe depletion of glutathione in the brain resulting from chronic exposure to oxidative stressors and extracellular glutamate leads to oxidation of the cysteine residue in PIN1, inactivating the protein and further contributing to PIN1 deficiency. Impaired autophagy leads to increased sensitivity of neurons to ferroptosis. It is imperative that further research be conducted to experimentally validate whether the mechanisms described here take place in response to chronic glyphosate exposure and whether this ultimately leads to autism.image
Delayed onset septic pelvic thrombophlebitis treated by tissue‐plasminogen activator following initial treatment for massive right ovarian vein thrombosis and methicillin‐resistant Staphylococcus aureus bacteremia: A case report
Authors: Miyamori Daisuke , Shigemoto Norifumi , Une Kazunobu , Kinoshita Hiroki , Harimoto Shina , Sakashita Tomohisa , Ito Masanori 
Published: May 2024

AbstractSeptic pelvic thrombophlebitis (SPT) is a rare condition that forms thrombosis in the pelvic veins, typically the ovarian veins, with subsequent infection and inflammation. We present a case of right ovarian vein thrombosis (ROVT), methicillin‐resistant Staphylococcus aureus (MRSA) bacteremia, and delayed onset of SPT symptoms, requiring tissue‐plasminogen activator. A 40‐year‐old woman, G3P2, at 38 weeks' gestation, was admitted with a fever of 39°C. She had cervical insufficiency and had been often on bed rest. Blood culture revealed MRSA and computed tomography revealed a large ROVT. She received vancomycin and direct oral anticoagulant, and her fever resolved by day 3. On day 16, fever recurred with severe pain over the ROVT. Second computed tomography showed thickening of venous wall with enhancement around ROVT, consistent with SPT. Since pain and fever gradually exacerbated despite treatment with DOAC and antimicrobials, she was started on heparin and tissue plasminogen activator on days 23 and 25, respectively. Along with recanalization on the thrombosis by day 29, fever and abdominal pain resolved. We experienced a case of delayed onset SPT associated with MRSA bacteremia and a large ROVT. MRSA bacteremia might cause the originally existing ROVT to become an infection source, resulting in SPT with recurrent symptoms and long‐term treatment. Early and strict anticoagulation is crucial in cases with a large thrombosis and bacteremia, due to the high risk of progression to SPT. This case highlights the importance of recanalization for the treatment of SPT and usefulness of administration of tissue‐plasminogen activator for the massive thrombosis.