bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Chart Analysis of Psychiatry Referrals for Hospitalized COVID-19 Patients in a Dedicated COVID Hospital in a Metropolitan City in India
Authors: Shelke Swati B. , Khar Prerna Balkrishen , Kedare Jahnavi , Somaiya Mansi , Shah Henal , Chakraborty Bijoya , Bhalke Sagar , Minhas Snehil , Nagda Mauni 
Published: May 2024

Abstract

Background:
The COVID-19 pandemic has been associated with multiple psychiatric problems in the general population as well as in those admitted with the infection. Studies done so far have mainly focused on the general population. It is important to address the needs and gaps in mental and psychological aspect of health of patients admitted with the infection to improve their overall prognosis. This study was undertaken with the aim to study the pattern of psychiatric referrals of hospitalized COVID-19 patients and to find out if there is any association between their socio-demographics, severity of COVID-19 infection, inflammatory markers, and co-morbidities.

Materials and Methods:
A descriptive, retrospective chart analysis of the record of 160 psychiatry referrals for COVID-19 patients seen by the on-call psychiatrist from May 2020 to October 2020 in a tertiary care hospital was undertaken. Sociodemographic data, severity of COVID-19 infection, blood investigation reports, psychiatric symptoms, diagnosis and management were recorded, tabulated, and analyzed using SPSS 20.

Results:
Referrals were more for individuals having moderate-to-severe COVID-19 infection, in elderly patients and in males. The most common reason for referral was disorientation (27.5%) and insomnia (27.5%), followed by the patient having a preexisting psychiatric illness (15%). The most common psychiatric diagnosis was delirium secondary to general medical condition, (28%), followed by anxiety and depressive spectrum disorders (23.75%). 32.5% of the patients referred had a past history of psychiatric illness, the most common being substance use disorder, followed by major depressive disorder and mixed anxiety depression. With the increase in the age of the individuals, the number of referrals for males was significantly more as compared to females (P = 0.00). No statistically significant association was found between age (P = 0.83), gender (P = 0.99), and psychiatric diagnosis. No significant association was found between the severity of COVID-19 and psychiatric diagnosis (P = 0.69).

Conclusion:
It is essential to screen for psychiatric disorders in patients admitted for COVID, as it goes a long way in reducing the overall morbidity and improves patient cooperation for various procedures which could be life-saving.
Proportion of Newly Detected Hypothyroidism among the Diabetic and Nondiabetic Pregnant Ladies and Correlation of Different Parameters with Thyroid Stimulatory Hormone in Pregnancy Attending a Tertiary Care Hospital
Authors: Dutta Mita , Islam Mohammad Aminul , Tabassum Maliha , Islam Md. Shafikul , Rezwana Israt , Sumyia Umme , Ghosh Parijat , Afsana Faria , Amin Md. Feroz , Pathan Md. Faruque 
Published: May 2024

ABSTRACT

Background:
Subclinical hypothyroidism and gestational diabetes are the two most common endocrinopathy encountered in daily clinical practice. Many literature showed a higher frequency of hypothyroidism in the persons with diabetes but others did not find it.

Objectives:
The study was intended to compare the proportion of newly detected hypothyroidism in persons with diabetes and without diabetes in pregnancy (DIP).

Materials and Methods:
This cross-sectional, observational study enrolled 175 pregnant women by convenient sampling from the Department of Obstetrics and Gynecology, BIRDEM General Hospital, with or without diabetes after IRB clearance. According to the study protocol, Thyroid function test (TFT) and oral glucose tolerance test were done in the participants. Thyroid stimulatory hormone (TSH), free thyroxin, and antithyroid antibodies were tested using the chemiluminescent technique by the ADVIA centaur, Siemens. Plasma glucose was analyzed by Advia-1800, SIEMENS, USA by glucose oxidase method. Data were analyzed by SPSS version 25. Nonparametric tests were chosen for statistical analysis.

Results:
The median maternal age was 30 years, and half of the participants had a family history of diabetes mellitus (DM). Hundred patients had diabetes either gestational DM or DIP or preexisting diabetes. Among the persons with diabetes, 34% had hypothyroidism, and in euglycemic patients, 29.3% had hypothyroidism. There was no statistically significant (P = 0.785) difference in the median values of TSH across the glycemic status among the hypothyroid subjects. TSH had a positive correlation with thyroid peroxidase antibody (P = 0.174) within the hypothyroid patients. In the study subjects, TSH was inversely correlated with hemoglobin (P < 0.001).

Conclusions:
There is no statistically significant concordance in diagnosing hypothyroidism in pregnancy between the persons with diabetes and without diabetes.
Work stress and caring intention among health care workers in Taiwan during the COVID-19 pandemic
Authors: Fu Ken-Hui , Lai Hsiang-Fen , Weng Chia-Sui , Huang Wen-Hao , Lin Cheng-Chih , Wu Ying-Hui 
Published: May 2024

Abstract

Background
Healthcare workers may feel stress when caring for patients suspected as having a highly infectious and novel disease, such as the coronavirus disease 2019 (COVID-19).

Objectives
This study aimed to identify the psychological responses and factors affecting these responses among healthcare workers in Taiwan during the COVID-19 pandemic.

Methods
Healthcare workers regardless of their experience in caring for COVID-19 patients in our hospital voluntarily participated in this cross-sectional study in April 2021. We used a self-assessment questionnaire with 70 items to identify the psychological responses and affecting factors.

Results
The experience of caring for COVID-19 patients was significantly associated with eight stressors, including “frequent modification of infection control procedures,” “worrying about being negligent and endangering coworkers,” “worrying about lack of manpower,” “being without a properly fitted environment,” “protective gears being a drag in providing quality care,” “protective gears causing physical discomfort,” “worrying about inflicting COVID-19 on family” and “worrying about nosocomial spread.” Using multivariate logistic regression, “switching thoughts and facing the situation with positive attitudes” (odds ratio: 2.974, P = 0.011), “ever caring COVID-19 patients” (odds ratio: 1.990, P = 0.018), “I felt scared” (odds ratio: 0.180, P < 0.001), and “I thought it is unlucky” (odds ratio: 0.492, P = 0.029) were identified as independent factors for the healthcare workers’ willingness to participate in future missions regarding infectious respiratory diseases.

Conclusion
The experience of caring for COVID-19 patients was significantly associated with several stressors related to psychological, practical, and environmental aspects, but not with immediate reactions to the mission. Experiences in caring for COVID-19 patients and positive attitudes could increase the healthcare workers’ willingness to participate in future missions regarding infectious respiratory diseases, and feeling scared and unlucky can reduce this willingness.
Mapping of Dental Journal Publishing in India - A Pilot Study on Epistemological Challenges in Southern Scholarly Publishing
Authors: Kummangal Abdul Majeed , Ahsan Auswaf , Babu V Manzoor , Payambrot Ramsheena , Mannakandath Master Luqman 
Published: May 2024

Abstract

Background:
Epistemic injustice and the so-called “predators” or illegitimate publishers are the challenges of Southern scholarly publishing. Even though open access (OA) publishing is revolutionary in academic publishing, increased compensation from authors in the form of author processing charges (APCs) by commercial publishers has marginalized knowledge creation in the Global South. The purpose of this study was to map the nature and scope of dental journal publishing in India.

Methods:
We searched databases like Scopus, WoS, DOAJ, and the UGC CARE list for dental journals published in India.

Result:
There are currently 35 active dental journals, which mostly belong to or are affiliated with non-profit organizations (26, 55.9%) or educational institutions (9, 25.8%). The publication of 25 journals has been outsourced to international commercial publishers, with most of these linked to non-profit organizations. About 39.8% of Indian dental journals are OA and almost half charge APCs. Around 60% of the Indian journals are indexed in Scopus, and slightly less than half (12) are included in the Web of Science (WoS).

Discussion:
The monopoly of international commercial publishers and the presence of APCs are the real culprits of epistemic injustice in Indian dental journal publishing. Besides, the identification of regional legitimate publishers would help demarcate the term “predatory publishing”.

Conclusion:
The post-colonial world witnessed an emergence in Southern scholarly publishing. However, the hegemony or neoliberal exploitation of international commercial publishers and the prolonged use of “predators” in scholarly debates marginalized the knowledge produced in the Global South.
Outcome of Hairy Cell Leukemia: A Single-center Study
Authors: Kaka Hana Kamal Yalda , Yassin Ahmed Khudair , Hasan Kawa Muhamedamin 
Published: May 2024

Abstract:

BACKGROUND:
Hairy cell leukemia (HCL) is a rare chronic B-cell lymphoproliferative disorder. Modern therapy with purine analogs and immunotherapy can provide long-term remission, but the risk of recurrence remains about 40%–50%. The aim of this study was to evaluate the outcome of patients with HCL who received treatment in Nanakali Hospital.

PATIENTS AND METHODS:
A retrospective cross-sectional study was carried out on 50 patients of HCL diagnosed from 2004 to 2022 in Nanakali Hospital in Erbil City, Kurdistan Region, Iraq. Demographics, clinical presentation, treatment data, complications, response, recurrence, and survival data were collected from medical records. The results were presented with descriptive statistics. Variables were compared by Chi-square analysis.

RESULTS:
The mean age was 52.64 ± 12.37 years, and 84% were male. The most common presenting symptoms were splenomegaly (18%) and fatigue (14%). The majority (69.6%) received cladribine; the response rate was 73.9%, with a complete remission (67.4%). 47.8% had recurrent disease. The most common adverse effects were febrile neutropenia (58.7%) and Grade III and IV hematologic toxicity (41.3%). The results were significantly associated with ANC pretreatment (P = 0.019), comorbidity (P = 0.001), and treatment response (P = 0.004). Cladribine–rituximab combination resulted in complete remission (100%). Ten-year overall survival was 70%.

CONCLUSIONS:
The results were broadly consistent with literature reports, demonstrating the efficacy and safety of cladribine with/without rituximab as first-line therapy for HCL but with a 30% mortality of concern. Further studies should identify modifiable factors that affect poor prognosis in subgroups to guide improvements in risk management of HCL.
Breast lymphomas: Clinical and pathological insights from a tertiary cancer care center in India
Authors: Singh Neha , Hayat Sadaf , Kumar Sujeet , Chowdhury Zachariah , Dhal Ipsita , Patne Shashikant CU , Kadali Kavya , Mishra Bal Krishna , Kapoor Akhil , Gupta Anuj , Singh Anil , Sansar Bipinesh 
Published: May 2024

ABSTRACT

Background:
Breast lymphomas are a rare group of malignancies that are further subdivided into primary and secondary.

AIMS:
To study the pathological and clinical course of breast lymphomas.

Materials and Methods:
This is a retrospective analysis of patients treated at our institute over a period of 4.5 years from September 2018 to February 2023. The details of all the patients diagnosed with breast lymphoma were reviewed and analysed for the histomorphological, immunohistochemical, clinical, and treatment details. Appropriate statistical analysis including Kaplan-Meier methods was used.

Results:
Out of 11 cases of breast lymphoma, five were primary and six were secondary. It was seen predominantly in females (82%) and the age range was 31 to 73 years. Diffuse large B cell lymphoma (DLBCL) was the predominant morphology (73%), along with single rare cases of ALK-negative anaplastic large cell lymphoma, Burkitt lymphoma, and small lymphocytic lymphoma. The treatment details were analyzed for 7 patients. The median follow-up was 28 months. Rituximab along with CHOP regimen or its variants was commonly used as first-line treatment with initial response rates of 71%. The median progression-free survival was 5 months. The median overall survival was 15 months.

Conclusion:
Lymphomas of the breast are rare but it is crucial to differentiate them from the commoner breast carcinomas as the treatment and prognosis vary vastly.
Potential role of CTNNA3 and FRMPD4 in vascular tumorous thrombosis of colon adenocarcinoma
Authors: Liu Bin , Xiang Yu , Guo Weihua 
Published: May 2024

ABSTRACT

Background:
Vascular tumorous thrombosis is a crucial pathological feature of malignant tumors that is closely associated with lymph node metastasis and is considered a form of tumor micrometastasis. Two downregulated genes, catenin alpha 3 (CTNNA3) and FERM and PDZ domain-containing 4 (FRMPD4), were selected by analyzing the differential expression of vascular tumorous thrombus in colon adenocarcinoma and paracancerous tissues. Further investigation revealed their potential role in the development of vascular tumorous thrombosis in colon adenocarcinomas.

Materials and Methods:
Candidate genes for vascular tumorous thrombosis in colon adenocarcinoma were screened using GSE127069, and pan-cancer verification and immune infiltration analysis were performed. The relationship between gene expression and vascular tumorous thrombosis was analyzed based on the level of gene mutations using cBioPortal. Finally, the collected clinical samples were used to verify expression.

Results:
CTNNA3 and FRMPD4 were expressed at low levels in the vascular tumorous thrombosis of colon adenocarcinoma and positively correlated with microsatellite instability. They are also closely related to the immune microenvironment and the infiltration of immune cell subtypes. Based on gene mutation analysis, gene deletion is suggested to be related to vascular invasion indicators. Finally, protein and messenger ribonucleic acid (mRNA) expression of CTNNA3 and FRMPD4 were downregulated in the vascular tumorous thrombosis samples of colon adenocarcinoma compared to normal glands from paracancerous tissues.

Conclusion:
Our study suggests that CTNNA3 and FRMPD4 could be promising biomarkers for vascular tumorous thrombosis in colon adenocarcinoma, potentially enabling the identification of micrometastases in this type of cancer. These findings suggest a novel strategy for the detection and management of colon adenocarcinomas.
Il-6 and MSH3 in colorectal carcinoma: Expression, relationship, and prognostic significance in 171 colorectal carcinoma cases
Authors: Kolay Bayram Elif , Ogut Betul , Inan Mehmet Arda , Dursun Ayse 
Published: May 2024

ABSTRACT

Aims:
Colorectal cancer (CRC), the most common type of gastrointestinal cancer, mostly develops as a result of environmental factors. Inflammation is a relatively uncommon but crucial contributor to its etiology, and inflammation is also thought to pose a risk in patients without a clinical diagnosis of inflammatory bowel disease. In cell lines, the proinflammatory cytokine interleukin-6 (IL-6) causes a cytosolic shift in the mismatch repair protein MSH3, accompanied by functional loss. This study aimed to evaluate IL-6 and MSH3 expression in 171 sporadic CRC samples by immunohistochemistry (IHC). High levels of IL-6 are hypothesized to cause MSH3 expression loss. We also explored the clinical/pathological aspects of IHC-detected MSH3 loss and the relationship between MSH3 expression and tumor-infiltrating lymphocytes (TILs).

Materials and Methods:
IL-6 and MSH3 IHC and H and E slides were evaluated by two pathologists. Clinical data were obtained from the institution’s database.

Results:
A relationship between MSH3 loss and IL-6 expression was not proven (P = 0.963). MSH3 staining was significantly reduced in the patient group with high TILs (P = 0.035). We observed 104 CRC cases (60.8%) with IL-6 expression and 85 cases (49.7%) with reduced MSH3 expression.

Conclusion:
This study did not demonstrate an association between IL-6 and MSH3 expression. As MSH3 is a relatively little-known protein, further large-scale studies are needed. The use of IHC to identify patients who may benefit from anti-IL-6 therapies in CRC in the future may be critical.
A rare case of multisystemic Langerhans cell histiocytosis in an adult affecting the thyroid gland, skeletal system, and pituitary gland: A case report
Authors: Patel Dhara , Doshi Preeti , Kesarkhane Milind , Mani Narayan S. 
Published: May 2024

ABSTRACT
Langerhans cell histiocytosis (LCH) is a rare disorder affecting usually children and rarely adults. The most common site affected is bone. The involvement of the thyroid gland in LCH is extremely rare and it is usually observed in an adult as a multisystemic disease. Adult males presented with anterior neck swelling, and fine needle aspiration cytology (FNAC) diagnosed it as suspicious for malignancy. On frozen sectioning, differential diagnosis was given as non-Hodgkin lymphoma and poorly differentiated malignancy. On immunohistochemistry (IHC), tumor cells were positive for CD1a and S100p. Thus, the final diagnosis offered was LCH-thyroid. The pathogenesis is unclear and believed to be related to immune dysfunction, cytokine mediators, viral infection, smoking, and genetic factors. Due to its rarity, thyroid LCH is often misinterpreted as other common disorders of the thyroid and results in delayed diagnosis. This case highlights the importance of histomorphology and the use of ancillary techniques such as IHC to arrive at a diagnosis in time and hence the treatment.
Challenges in the diagnosis and management of autoimmune hemolytic anemia: A case-based approach. Experience from a tertiary care hospital in the Haryana region
Authors: Sharma Geetika , More Shilpi , Rajput Saroj , Sharma Nimisha , Choudhary Sonu , Chatterjee Tathagata 
Published: May 2024

ABSTRACT

Background:
Autoimmune hemolytic anemia (AIHA) is a rare immune disorder which occurs when antibodies are directed against self red blood cells (RBCs) leading to hemolysis. AIHA is widely classified as warm autoimmune hemolytic anemia, cold agglutinin syndrome, mixed AIHA, paroxysmal cold hemoglobinuria and rarely drug induced AIHA. The pathogenesis of AIHA is complex interplay between genetic predisposition, immune dysregulation and enviornmental triggers. A direct antiglobulin test can be used to assess the immunological origin of the hemolysis in order to diagnose AIHA after identifying laboratory and clinical symptoms of hemolysis.

Objective:
The objective is to understand underlying mechanism in AIHAs, and usage of targeted therapies to modulate specific components of the immune response.

Materials and Methods:
We are hereby presenting a case series of 11 clinically suspected cases of AIHA in collaboration with their clinical features, immuno-hematological and other laboratory parameters, Flow cytometric analysis of lymphocyte subset in relevant cases, underlying etiology as well as serological subtype are also included.

Results:
Majority of the patients were categorized as secondary AIHA (7/11, 63.63%). Out of 11 cases 7 were serologically subtyped as warm AIHA (7/11, 63.63%) ,2 cases were DaaT negative AIHA (2/11;18.18%), 2 cases were characterized as mixed AIHA subtype (2/11, 18.18%).

Conclusion:
Accurate subtyping of AIHA requires a systematic immunohematological approach coupled with comprehensive evaluations of clinical, hematological, and biochemical parameters.
Amniotic Fluid Volume: An Important Deciding Factor for Pregnancy Continuation in Preterm Premature Rupture of Membranes
Authors: Ken Shweta , Gupta Ratan , Rani Kumari Usha , Saxena Purnima , Yadav Sunita , Bajaj Bindu 
Published: May 2024

Abstract

Aims and Objectives:
To find out various risk factors affecting fetomaternal outcomes in preterm premature rupture of membranes (PPROM).

Materials and Methods:
A prospective study after approval from the ethical committee was conducted at VMMC and Safdarjung Hospital, New Delhi, Department of Obstetrics and Gynaecology from December 2020 to May 2022 in which 100 pregnant women with preterm premature rupture of membrane between 32 and 36 weeks of gestation were enrolled. Patients were followed with Total leucocyte count (TLC), urine R/M, urine C/S, high vaginal swab C/S, and C-reactive protein along with routine antenatal care investigations. Intravenous antibiotics were given to all patients for 48 h followed by oral antibiotics for 5 days. All patients were on follow-up and managed conservatively and induction of labor was done at 37 weeks or earlier in case of fetal distress and presence of signs and symptoms of chorioamnionitis. Both mother and baby were followed till 7 days after delivery.

Results:
In the present study, we observed the following risk factors that had adverse effects on fetomaternal outcomes in PPROM patients. The association of oligohydramnios (amniotic fluid index [AFI] <5) with neonatal sepsis (P = 0.025) and neonatal death (P = 0.025) was found to be significant. Vaginal infection was found to be significantly associated with birth asphyxia (P = 0.024), APGAR <7 at 1 min (P = 0.015), neonatal intensive care unit (NICU) admission (P = 0.009), and postpartum hemorrhage (PPH) (P = 0.002). The association of urinary tract infection (UTI) with neonatal sepsis (P = 0.01), birth asphyxia (P = 0.005), APGAR <7 at 1 min (P = 0.001), NICU admission (P = 0.002), neonatal death (P = 0.01), and PPH (P = 0.0004) was found to be significant. We also observed that the duration from membrane rupture to delivery had no adverse effect on fetomaternal outcome, may be as we had given antibiotics to all patients from the time of admission.

Conclusions:
The conclusion from the present study was that oligohydramnios (AFI <5) is a significant risk factor for adverse neonatal outcomes in PPROM along with vaginal infections and UTIs. Hence, amniotic fluid volume should also be considered as an important deciding factor for pregnancy continuation in PPROM.