bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of Helicobacter pylori‐carcinogenic TNF‐alpha‐inducing protein inhibitors via daidzein derivatives through computational approaches
Authors: Tayyeb Jehad Zuhair , Mondal Shibam , Anisur Rahman Md , Kumar Swapon , Bayıl Imren , Akash Shopnil , Hossain Md. Sarowar , Alqahtani Taha , Zaki Magdi E. A. , Oliveira Jonas Ivan Nobre 
Published: May 2024

AbstractGastric cancer is considered a class 1 carcinogen that is closely linked to infection with Helicobacter pylori (H. pylori), which affects over 1 million people each year. However, the major challenge to fight against H. pylori and its associated gastric cancer due to drug resistance. This research gap had led our research team to investigate a potential drug candidate targeting the Helicobacter pylori‐carcinogenic TNF‐alpha‐inducing protein. In this study, a total of 45 daidzein derivatives were investigated and the best 10 molecules were comprehensively investigated using in silico approaches for drug development, namely pass prediction, quantum calculations, molecular docking, molecular dynamics simulations, Lipinski rule evaluation, and prediction of pharmacokinetics. The molecular docking study was performed to evaluate the binding affinity between the target protein and the ligands. In addition, the stability of ligand–protein complexes was investigated by molecular dynamics simulations. Various parameters were analysed, including root‐mean‐square deviation (RMSD), root‐mean‐square fluctuation (RMSF), radius of gyration (Rg), hydrogen bond analysis, principal component analysis (PCA) and dynamic cross‐correlation matrix (DCCM). The results has confirmed that the ligand–protein complex CID: 129661094 (07) and 129664277 (08) formed stable interactions with the target protein. It was also found that CID: 129661094 (07) has greater hydrogen bond occupancy and stability, while the ligand–protein complex CID 129664277 (08) has greater conformational flexibility. Principal component analysis revealed that the ligand–protein complex CID: 129661094 (07) is more compact and stable. Hydrogen bond analysis revealed favourable interactions with the reported amino acid residues. Overall, this study suggests that daidzein derivatives in particular show promise as potential inhibitors of H. pylori.
Dynamic liver volume change in predicting hepatic decompensation and long‐term effects of stereotactic body radiation therapy
Authors: Lee Sumin , Choi Jonggi , Park Jin‐hong , Lim Chae Yeon , Yang Eunyeong , Yoon Sang Min , Jung Jinhong 
Published: May 2024

AbstractBackground and AimThis study aimed to investigate the association between liver volume change and hepatic decompensation and compare the risk of hepatic decompensation in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC) who underwent stereotactic body radiation therapy (SBRT).MethodsA retrospective review of SBRT‐treated HCC and compensated LC without HCC patients was conducted. Liver volume was measured using auto‐segmentation software on liver dynamic computed tomography scans. The decompensation event was defined as the first occurrence of refractory ascites, esophageal variceal bleeding, hepatic encephalopathy, or spontaneous bacterial peritonitis. We evaluated the association between the rate of liver volume decrease and hepatic decompensation and compared decompensation events between the SBRT and LC cohorts using propensity score matching.ResultsA total of 138 patients from the SBRT cohort and 488 from the LC cohort were analyzed. The rate of liver volume decrease was associated with the risk of decompensation events in both cohorts. The 3‐year rate of decompensation events was significantly higher in the group with a liver volume decreasing rate > 7%/year compared with the group with a rate < 7%/year. In the propensity score‐matched cohort, the 3‐year rate of decompensation events after a single session of SBRT was not significantly different from that in the LC cohort.ConclusionsThe rate of liver volume decrease was significantly associated with the risk of hepatic decompensation in both HCC patients who received SBRT and LC patients. A single session of SBRT for HCC did not result in a higher decompensation rate compared with LC.
‘It's not something I really think about’: Parents' perspectives and practices about how much food to offer in early childhood
Authors: Vidal Leticia , Brunet Gerónimo , Girona Alejandra , Machín Leandro , Curutchet María R. , de León Carolina , Ares Gastón 
Published: May 2024

AbstractChildren are born with an innate capacity to self‐regulate their energy intake, but cues from the food environment can undermine children's self‐regulation, promoting overconsumption, and challenging energy balance. The size of the portion offered by parents and caregivers has been shown to be correlated with how much food children consume, which is known as the portion size effect. Furthermore, some parental feeding practices may interfere with children's ability to self‐regulate. The present research explored parents' perspectives and practices about how much food they offer to their children in Uruguay. Forty‐two in‐depth interviews with parents of children between 6 months and 5 years old were conducted. Results showed that parental decisions about portion sizes for their children were mostly unconscious and intuitive. Parents were unconcerned about portion sizes, mainly due to the belief that children are able to self‐regulate. Although parents identified themselves as mainly responsible for deciding how much food to serve their children, the majority reported to be responsive when their child refuses to eat or finish their meal, or when they request to eat more. Coercive feeding practices were only mentioned by a minority of parents.Practical ApplicationsResults from the present work stress the need to raise awareness of children's vulnerability to portion size effects, since portion size selection seems to be a highly arbitrary process. Further research is needed to identify the best approaches to disseminate information among parents and caregivers to promote appropriate portion sizes for children, as well as responsive feeding practices.
Disease recurrence during supportive therapy following peri‐implantitis treatment: A retrospective study
Authors: Monje Alberto , Nart José 
Published: May 2024

AbstractAimSupportive therapy is key to prevent disease recurrence after peri‐implantitis treatment. The primary objective was to quantify disease recurrence during supportive peri‐implant therapy (SPIT) after peri‐implantitis treatment. A secondary objective was to assess the success/failure of cumulative interceptive supportive therapy (CIST) after peri‐implantitis treatment.MethodsCompliers (whether regular or erratic) with SPIT after peri‐implantitis treatment during ≥12 months were retrospectively evaluated. CIST was prescribed whenever residual pockets ≥6 mm concomitant with profuse bleeding on probing (disease recurrence) were identified. Patient‐ and implant‐related factors were analyzed to explore their associations with disease recurrence and the need for CIST.ResultsDisease recurrence was considered in 28 patients (40 implants). Of these, 14 patients (23 implants) further demonstrated radiographic evidence of progressive bone loss (≥1 mm). This represented an overall disease recurrence following peri‐implantitis treatment of ~20% and ~ 10% at patient and implant levels, respectively. Smokers, patients diagnosed at baseline with periodontitis grade C, and males were significantly more prone to exhibit recurrence. Patients undergoing CIST due to instability were not likely to respond favorably (~70% continued to exhibit residual pockets).ConclusionDisease recurrence during SPIT following peri‐implantitis treatment on selected cases is ~20%. Patients undergoing CIST due to instability are not likely to respond favorably.
Religious Correlates of Religious Victimization in Youth: Findings from Two Nationally Representative Surveys
Authors: Jochman Joseph C. , Schwadel Philip 
Published: May 2024

AbstractReligious victimization is a social stressor harmful to identity and well‐being. In this article, we examine how religious victimization is associated with key religious factors in youth using two different data sets collected 17 years apart. The results from both surveys show that youth affiliated with non‐Christian religious traditions, youth who more frequently attend services, and youth who talk more frequently with their parents about religion have a relatively high likelihood of religious victimization. Moreover, Catholic and mainline Protestant youth have relatively low likelihoods of religious victimization, but these findings did not hold across both sources of data. We suggest these patterns reflect cultural views regarding secularization as well as the cultural normativity of Christianity and associated behaviors in the United States. We conclude by encouraging school‐based, antibullying programs to include religion and religiosity in efforts to reduce and prevent youth bullying.
Satisfaction with public goods provision and citizen preferences for institutional changes: Evidence from the dictatorship‐era constitution in Chile
Authors: Acuña‐Duarte Andrés A. , León Javier A. , Salazar César A. 
Published: May 2024

AbstractWe argue that a deficient provision of public goods may influence citizen satisfaction with the status quo, thereby encouraging demands for institutional changes. We formalize and test this relationship using prior data related to the recent constitutional process carried out in Chile to replace its dictatorship‐era constitution. Individual‐level data from the Chile 2016/17 AmericasBarometer survey are used to estimate ordered and multinomial probit models to study the determinants of citizen preferences for constitutional change, distinguishing between amendment and replacement. The main findings reveal that preferences for reforming the Chilean constitution can be driven by greater discontent with public goods provision. These results remain robust when estimating pseudo‐panel models using cohort‐level data and examining coefficient stability. Moreover, higher levels of corruption are associated with a stronger demand for constitutional replacement, suggesting a potential rupture in the shared social contract due to poor governance and lower political equality.
Does maternity leave reform impact on the labour supply of the elderly? Evidence from a natural experiment in Vietnam
Authors: Khiem Phuong Huu , Linh Do Bao , Khanh Tran Viet , Tai Do Anh 
Published: May 2024

AbstractThe aging population has been rising rapidly in every country, slowing the labour force and causing lower per capita growth. Many policies incentivize working in old age as it can alleviate the challenges of the aging population. This study examines the impacts of the extended maternity leave reform in Vietnam on elderly labour market outcomes. As grandparents' childcare responsibility may be reduced by maternal childcare following the extended maternal leave, especially for elderly living with children smaller than 1 year old, the reform gives older adults or grandparents more flexibility to join the labour market. Using the difference‐in‐differences model, we find that older people in the treatment group are more likely to return to the labour market following the reform implementation. The effect is positive and most robust for the self‐employment group rather than waged employment and for males rather than females. Our study suggests that there is a need for a policy design to shift public finance into the healthcare and pension system.
Active Language Modulates Color Perception in Bilinguals
Authors: Sinkeviciute Akvile , Mayor Julien , Vulchanova Mila Dimitrova , Kartushina Natalia 
Published: May 2024

AbstractColor terms divide the color spectrum differently across languages. Previous studies have reported that speakers of languages that have different words for light and dark blue (e.g., Russian siniy and goluboy) discriminate color chips sampled from these two linguistic categories faster than speakers of languages that use one basic color term for blue (e.g., English blue). This effect has been reported to be disrupted when participants engaged in a verbal interference task, suggesting that active language use can modulate the linguistic category effect. The current study provided a stringent test of this hypothesis by examining color discrimination under verbal interference in bilinguals speaking Lithuanian (two blue categories) and Norwegian (one blue category). The results revealed that the language activated during verbal interference had a significant impact on bilinguals’ color discrimination. Specifically, Lithuanian–Norwegian bilinguals exhibited a color category effect only when performing the task under verbal interference in Lithuanian but not in Norwegian. This demonstrated, within the same individuals, the momentary effect of active language processing on color perception.
The hot sex: is there evidence for climate‐driven sex allocation in mammals?
Authors: Firman Renée C. 
Published: May 2024

Abstract

Climate change predictions indicate that future conditions will be hotter and drier, and rainfall will be more variable. Climatic conditions can affect individual condition and shape offspring sex ratios. The implications that climate change have for mammalian sex allocation are vast but are currently poorly understood.

There are several scenarios under which climate‐driven sex allocation responses might emerge. Here, I make predictions on the direction of offspring sex ratio biases under hypothetical situations of restricted resource availability and altered social/spatial structures that may result from hotter, drier conditions.

I searched the literature for existing evidence of climate‐driven offspring sex ratio biases among individuals studied in wild populations. There was no strong, directional support for the production of sons or daughters under ‘good’ or ‘poor’ climatic conditions among the 30 studies had reported on climatic variables and offspring sex ratio.

I also searched the literature for studies that assessed maternal condition and offspring sex ratio in natural populations (i.e. there is a link between climate, resource availability and maternal condition). Of the 27 investigations, half reported a bias in favour of sons born to mothers in ‘good’ condition (56%). I discuss how this outcome could be due to a publication bias, or that it may indicate that low resource availability has the potential to lead to mothers in poor condition and the production of fewer sons.

I consider the conservation implications of climate‐driven offspring sex ratios skews being carried through to the population level. I discuss the challenge of being able to account for the multiple factors that influence offspring sex ratios in natural populations and emphasise the growing need for more research in this important area of mammalian evolutionary ecology.
Crack pattern–based machine learning prediction of residual drift capacity in damaged masonry walls
Authors: Pereira Mauricio , D'Altri Antonio Maria , de Miranda Stefano , Glisic Branko 
Published: May 2024

AbstractIn this paper, we present a method based on an ensemble of convolutional neural networks (CNNs) for the prediction of residual drift capacity in unreinforced damaged masonry walls using as only input the crack pattern. We use an accurate block‐based numerical model to generate mechanically consistent crack patterns induced by external actions (earthquake‐like loads and differential settlements). For a damaged masonry wall, we extract the crack width cumulative distribution, we derive a crack width exceedance curve (CWEC), and we evaluate the drift loss (DL) with respect to the undamaged wall. Numerous pairs of CWEC and DL are thus generated and used for training (and validating) an ensemble of CNNs generated via repeated ‐folding cross validation with shuffling. As a result, a method for damage prognosis (Level IV of SHM) is provided. Such method appears general, inexpensive, and able to adequately predict the DL using as only input the CWEC, providing real‐time support for decision making in damaged masonry structures.
A causal discovery approach to study key mixed traffic‐related factors and age of highway affecting raveling
Authors: Wang Zili , Krishnakumari Panchamy , Anupam Kumar , van Lint Hans , Erkens Sandra 
Published: May 2024

AbstractThe relationship between real‐world traffic and pavement raveling is unclear and subject to ongoing debates. This research proposes a novel approach that extends beyond traditional correlation analyses to explore causal mechanisms between mixed traffic and raveling. This approach incorporates the causal discovery method, and is applied to five Dutch porous asphalt (PA) highway sites that have substantial data sets. Findings indicate a nonlinear relationship between traffic volume and raveling, with road age emerging as a shared contributor. The results also suggest that the degree to which different vehicle types contribute as a causal factor for raveling varies with carriageway configurations and lane characteristics. This underlines the need for targeted maintenance strategies. Challenges remain due to confounding correlations among traffic variables, necessitating further development of causal discovery models. This study may not conclusively resolve the debate on to what extent traffic contributes to raveling, but we argue we provide sufficient evidence against rejecting this hypothesis.
Weight management using meal replacements and cardiometabolic risk reduction in individuals with pre‐diabetes and features of metabolic syndrome: A systematic review and meta‐analysis of randomized controlled trials
Authors: Noronha Jarvis C. , Nishi Stephanie K. , Khan Tauseef A. , Blanco Mejia Sonia , Kendall Cyril W. C. , Kahleová Hana , Rahelić Dario , Salas‐Salvadó Jordi , Leiter Lawrence A. , Lean Michael E. J. , Sievenpiper John L. 
Published: May 2024

SummaryThis review synthesized the evidence from randomized controlled trials comparing the effect of meal replacements (MRs) as part of a weight loss intervention with conventional food‐based weight loss diets on cardiometabolic risk in individuals with pre‐diabetes and features of metabolic syndrome. MEDLINE, EMBASE, and Cochrane Library were searched through January 16, 2024. Data were pooled using the generic inverse variance method and expressed as mean difference [95% confidence intervals]. The overall certainty of the evidence was assessed using GRADE. Ten trials (n = 1254) met the eligibility criteria. MRs led to greater reductions in body weight (−1.38 kg [−1.81, −0.95]), body mass index (BMI, −0.56 kg/m2 [−0.78, −0.34]), waist circumference (−1.17 cm [−1.93, −0.41]), HbA1c (−0.11% [−0.22, 0.00]), LDL‐c (−0.18 mmol/L [−0.28, −0.08]), non‐HDL‐c (−0.17 mmol/L [−0.33, −0.01]), and systolic blood pressure (−2.22 mmHg [−4.20, −0.23]). The overall certainty of the evidence was low to moderate owing to imprecision and/or inconsistency. The available evidence suggests that incorporating MRs into a weight loss intervention leads to small important reductions in body weight, BMI, LDL‐c, non‐HDL‐c, and systolic blood pressure, and trivial reductions in waist circumference and HbA1c, beyond that seen with conventional food‐based weight loss diets.
Targeted therapies in ameloblastomas and amelobastic carcinoma—A systematic review
Authors: Bologna‐Molina Ronell , Schuch Lauren , Magliocca Kelly , van Heerden Willie , Robinson Liam , Bilodeau Elizabeth Ann , Hussaini Haizal Mohd , Soluk‐Tekkesin Merva , Adisa Akinyele Olumuyiwa , Tilakaratne Wanninayake Mudiyanselage , Li Jiang , Gomez Ricardo Santiago , Hunter Keith David 
Published: May 2024

AbstractTargeted therapy has the potential to be used in the neoadjuvant setting for odontogenic tumors, reducing the morbidities associated with major surgery. In this regard, the aim of this study was to summarize the current evidence on the different forms of targeted therapy, effectiveness, and drawbacks of this course of treatment. Four databases were searched electronically without regard to publication date or language. Grey literature searches and manual searches were also undertaken. Publications with sufficient clinical data on targeted therapy for odontogenic tumors were required to meet the criteria for eligibility. The analysis of the data was descriptive. A total of 15 papers comprising 17 cases (15 ameloblastomas and 2 ameloblastic carcinomas) were included. Numerous mutations were found, with BRAF V600E being most common. Dabrafenib was the most utilized drug in targeted therapy. Except for one case, the treatment reduced the size of the lesion (16/17 cases), showing promise. Most of the adverse events recorded were mild, such as skin issues, voice changes, abnormal hair texture, dry eyes, and systemic symptoms (e.g., fatigue, joint pain, and nausea). It is possible to reach the conclusion that targeted therapy for ameloblastoma and ameloblastic carcinoma may be a useful treatment strategy, based on the findings of the included studies.
FADD amplification is associated with CD8+ T‐cell exclusion and malignant progression in HNSCC
Authors: Zheng Yang , Sheng Surui , Ma Yanni , Chen Yinan , Liu Ruixin , Zhang Wuchang , Zhang Li , Liu Zhonglong , He Yue , Zeng Hanlin , Zhang Zhiyuan 
Published: May 2024

AbstractObjectiveThis study aimed to clarify the relationship between FADD amplification and overexpression and the tumor immune microenvironment.MethodsImmunohistochemical staining and bioanalysis were used to analyze the association between FADD expression in tumor cells and cells in tumor microenvironment. RNA‐seq analysis was used to detect the differences in gene expression upon FADD overexpression. Flow cytometry and multicolor immunofluorescence staining (mIHC) were used to detect the differences in CD8+ T‐cell infiltration in FADD‐overexpressed cells or tumor tissues.ResultsOverexpression of FADD significantly promoted tumor growth. Cells with high FADD expression presented high expression of CD276 and FGFBP1 and low expression of proinflammatory factors (such as IFIT1‐3 and CXCL8), which reduced the percentage of CD8+ T cells and created a “cold tumor” immune microenvironment, thus promoting tumor progression. In vivo and in vitro experiment confirmed that tumor tissues with excessive FADD expression exhibited CD8+ T‐cell exclusion in the microenvironment.ConclusionOur preliminary investigation has discovered the association between FADD expression and the immunosuppressive microenvironment in HNSCC. Due to the high frequent amplification of the chromosomal region 11q13.3, where FADD is located, targeting FADD holds promise for improving the immune‐inactive state of tumors, subsequently inhibiting HNSCC tumor progression.