bluuebunny/crossref_metadata_2025_split huggingface dataset:
Auditory steady state response in bipolar disorder: relation to clinical state, cognitive performance, medication status, and substance disorders
Authors: Rass Olga , Krishnan Giri , Brenner Colleen A , Hetrick William P , Merrill Colleen C , Shekhar Anantha , O’Donnell Brian F 
Published: December 2010

Rass O, Krishnan G, Brenner CA, Hetrick WP, Merrill CC, Shekhar A, O’Donnell BF. Auditory steady state response in bipolar disorder: relation to clinical state, cognitive performance, medication status, and substance disorders. Bipolar Disord 2010: 12: 793–803. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objectives:  Abnormalities in auditory steady state response (ASSR) at gamma range frequencies have been found in bipolar disorder, but the relationship of these neurophysiological disturbances to clinical factors has not been well characterized. We therefore evaluated the ASSR in bipolar disorder and examined its sensitivity to clinical symptoms, cognitive function, and pharmacological treatment.Methods:  A total of 68 patients with bipolar disorder and 77 control participants were evaluated. Click trains presented at 20, 30, 40, and 50 Hz evoked ASSRs. Mean trial power (MTP) and phase locking factor (PLF) measured response magnitude and phase synchronization of the ASSR at each stimulation frequency. Clinical state, pharmacological treatment, and neuropsychological performance were assessed, and their respective relationships with ASSR measures were evaluated.Results:  Patients with bipolar disorder showed reduced MTP and PLF compared to control participants. Bipolar disorder patients taking psychotropic medications had decreased PLF relative to patients withdrawn from medications. Control participants performed better on neuropsychological tests than bipolar disorder patients; however, test scores did not correlate with ASSR measures.Conclusions:  Deficits in the generation and maintenance of ASSR are present in bipolar disorder, implicating disturbances in auditory pathways. ASSR may be sensitive to medication status. Other clinical features, including mood state, psychotic features, cognitive performance, smoking, or history of substance use disorder, were unrelated to MTP or PLF.
Striatal structure and function in mood disorders: a comprehensive review
Authors: Marchand William R , Yurgelun‐Todd Deborah 
Published: December 2010

Marchand WR, Yurgelun‐Todd D. Striatal structure and function in mood disorders: a comprehensive review. Bipolar Disord 2010: 12: 764–785. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objectives:  A large and diverse literature has implicated abnormalities of striatal structure and function in both unipolar and bipolar disorder. Recent functional imaging studies have greatly expanded this body of research. The aim of this review is to provide a comprehensive and critical appraisal of the relevant literature.Methods:  A total of 331 relevant articles were reviewed to develop an integrated overview of striatal function in mood disorders.Results:  There is compelling evidence from multiple studies that functional abnormalities of the striatum and greater corticostriatal circuitry exist in at least some forms of affective illness. The literature does not yet provide data to determine whether these aberrations represent primary pathology or they contribute directly to symptom expression. Finally, there is considerable evidence that bipolar disorder may be associated with striatal hyperactivity and some suggestion that unipolar illness may be associated with hypoactivation.Conclusions:  Additional research investigating striatal function in affective disorders will be critical to the development of comprehensive models of the neurobiology of these conditions.
Social competence and observer‐rated social functioning in bipolar disorder
Authors: Depp Colin A , Mausbach Brent T , Harvey Philip D , Bowie Christopher R , Wolyniec Paula S , Thornquist Mary H , Luke James R , McGrath John A , Pulver Ann E , Patterson Thomas L 
Published: December 2010

Depp CA, Mausbach BT, Harvey PD, Bowie CR, Wolyniec PS, Thornquist MH, Luke JR, McGrath JA, Pulver AE, Patterson TL. Social competence and observer‐rated social functioning in bipolar disorder. Bipolar Disord 2010: 12: 843–850. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S.Objective:  Impairment in social functioning appears to be common in bipolar disorder, although estimates have been derived largely from self‐report measures. We examined performance‐based and observer‐based ratings of social competence and functioning and assessed the contribution of symptoms and neurocognitive ability to social functioning in bipolar disorder.Methods:  In this cross‐sectional study, 164 subjects with bipolar disorder were administered the performance‐based Social Skills Performance Assessment (SSPA), rated by an informant on the Specific Level of Functioning (SLOF)–Interpersonal subscale, received clinical ratings of depression and manic symptoms, and performed neurocognitive tests. We assessed the proportion of patients exhibiting social deficits and examined the associations between composite measures of neurocognitive ability, depression and manic symptoms, and SSPA scores with informant‐rated, real‐world social functioning.Results:  Mean age of the sample was 47.6 years (SD = 14.1). Subjects were experiencing, on average, mild levels of depression and minimal manic symptoms. A total of 29% exhibited norm‐referenced impairment on the SSPA, and 64% registered at least one impairment on SLOF items; unemployed subjects had lower SSPA and SLOF ratings. Neurocognitive performance correlated with both performance‐based and observer‐rated social functioning, whereas depressive and manic symptoms correlated only with observer‐rated social impairments. In multivariate models, depression was the most potent association with social functioning, and impairment in social competence (i.e., capacity) increased the strength of the relationships between depression and neurocognitive impairment and social functioning (i.e., real‐world functioning).Conclusions:  Our study confirmed the negative relationship of bipolar depression with social functioning. A subgroup of outpatients with bipolar disorder has impaired social competence, which, when present, worsened the impact of depression and cognitive impairment on social functioning.
Haemovigilance: an effective tool for improving transfusion practice
Authors: de Vries R. R. P. , Faber J.‐C. , Strengers P. F. W. ,   Members of the Board of the International Haemovigilance Network
Published: December 2010

Haemovigilance is a tool to improve the quality of the blood transfusion chain, primarily focusing on safety. In this review we discuss the history and present state of this relatively new branch of transfusion medicine as well as some developments that we foresee in the near future. The top 10 results and conclusions are:Haemovigilance systems have shown that blood transfusion is relatively safe compared with the use of medicinal drugs and that at least in Europe blood components have reached a high safety standard.The majority of the serious adverse reactions and events occur in the hospital.The majority of preventable adverse reactions are due to clerical errors.Some adverse reactions such as anaphylactic reactions often are not avoidable and therefore have to be considered as an inherent risk of blood transfusion.Well‐functioning haemovigilance systems have not only indicated how safety should be improved, but also documented the success of various measures.The type of organisation of a haemovigilance system is of relative value, and different systems may have the same outcome.International collaboration has been extremely useful.Haemovigilance systems may be used for the vigilance and surveillance of alternatives for allogeneic blood transfusion such as cell savers.Haemovigilance systems and officers may be used to improve the quality of aspects of blood transfusion other than safety, such as appropriate use.Haemovigilance systems will be of benefit also for vigilance and surveillance of the treatment with other human products such as cells, tissues and organs.
Characteristics of prion‐filtered red cells suspended in pathogen‐inactivated plasma (MB treated or solvent‐detergent treated) for neonatal exchange transfusion
Authors: Hornsey V. S. , Casey C. , McColl K. , Young H. , Drummond O. , McMillan L. , Morrison A. , Prowse C. V. 
Published: December 2010

Background and Objectives  Neonates undergoing exchange transfusion require < 5‐day‐old red cells suspended in plasma. This study assesses the effect of replacing the saline, adenine, glucose and mannitol (SAGM) of prion reduced (P‐Capt) red cells with either methylene blue–treated plasma (MBTFFP) or OctaplasLG to reduce the risk of variant Creutzfelt–Jakob disease transmission.Materials and Methods  Twenty leucoreduced red cell units in SAGM were prion reduced on day 1. The SAGM was replaced by MBTFFP (n = 10) or OctaplasLG (n = 10). The units were irradiated and stored at 4°C for 24 h. A further 20 units were stored for 5 days before being processed as above. Haemolysis (%), potassium, ATP, 2,3‐DPG and plasma proteins were measured.Results  Haemolysis remained low (≤ 0·16%). Following irradiation and storage, red cells in both types of plasma showed similar changes in potassium and ATP concentrations. The 2,3‐DPG concentrations were well maintained although lower in red cells in OctaplasLG compared with those in MBTFFP (4·79 vs. 6·83 μmoles/g Hb on day 6). MBTFFP contained lower concentrations of fibrinogen, FV and FVIII. In OctaplasLG, alpha‐2‐antiplasmin was approximately 0·4 U/ml lower than in MBTFFP. After 24 h at 4°C, free protein S in OctaplasLG fell from 0·82 to 0·57 IU/ml. Other plasma proteins, in both types of plasma, were stable.Conclusions  Red cells in both types of plasma demonstrated similar storage characteristics. The plasma proteins, except protein S in OctaplasLG, were stable over 24 h at 4°C in both types of plasma, and low FVIII concentrations were noted in the MBTFFP (group O) units used.
Effect of rate and delay of cooling during initial cooling process: in vitro effect on red cells
Authors: Bontekoe I. J. , van der Meer P. F. , de Korte D. 
Published: December 2010

Background  Whole blood is stored at room temperature (RT) until processing into components. After separation and filtration, the RCC has to be cooled from RT to +2 – 6°C. Different start times of the cooling process and different cooling rates can be encountered in daily routine. The effect of these parameters of the initial cooling of leucoreduced red cell concentrates (LR‐RCC) on in vitro quality is not known.Methods  In paired experiments (n = 12), LR‐RCCs in SAGM were cooled immediately after preparation from RT to +2 to +6°C either ‘fast’ (within 2½ h) or ‘slow’ (within 10–24 h) or ‘slow’ after a holding period of 6, 12, 18 or 24 h. Units were then stored at +2 – 6°C for 42 days and sampled at regular intervals for in vitro analysis.Results  Irrespective of the start time and cooling rate during the initial cooling process, all units maintained good in vitro quality up to Day 42 with haemolysis <0·8%. Adenosine triphosphate (ATP) levels remained >2·7 μmol/g Hb in 99% of all units up to Day 35. Differences in pH, ATP content and 2,3‐DPG content between the groups were largest at Day 2 or 3 but generally disappeared during storage.Conclusion  Start time and cooling rate of the initial cooling process had minor effects on in vitro quality of red cells. LR‐RCCs can be stored up to 24 h before cooling down to +2 – 6°C without deleterious effects on in vitro parameters during 42‐day storage.
Plasticity of reproductive traits responding to variation in light availability at the rosette stage of the first year in a strict biennial, Pedicularis torta, from a field on the Qinghai–Tibet Plateau, China
Authors: ZHANG LONGCHONG , GUO HUI , WANG MANTANG , DU GUOZHEN 
Published: December 2010

AbstractLight is a fundamental heterogeneous environmental factor for plants and often varies at both spatial and temporal scales. In the present study, we carried out a shading experiment to investigate the effect of variable light availability at the rosette stage of the first year in the strict biennial species Pedicularis torta (an endemic species of the Qinghai‐Tibet Plateau) on reproductive traits (i.e. total number of flowers per plant, total number of fruits per plant/total number of flowers per plant, the number of seeds per fruit, mean individual seed mass and estimation of the total number of seeds per plant, plant size at maturity in the second year and on the relationships between reproductive traits and plant size at this stage). We found that light availability affected most of the reproductive traits (except for mean individual seed mass), plant size at maturity in the second year, and the relationship between the total number of flowers per plant and plant size at this stage. Our results indicate that reproductive traits respond to changes in light availability during the rosette plant stage.
Impact of insulin resistance, insulin and adiponectin on kidney stones in the Japanese population
Authors: Ando Ryosuke , Suzuki Sadao , Nagaya Teruo , Yamada Tamaki , Okada Atsushi , Yasui Takahiro , Tozawa Keiichi , Tokudome Shinkan , Kohri Kenjiro 
Published: December 2010

Objectives:  It has been reported that kidney stones are linked to metabolic syndrome (MetS), which is characterized by insulin resistance. The aim of the present study was to examine the association of insulin resistance, insulin and adiponectin with kidney stones in a Japanese population.Methods:  From February 2007 to March 2008, 1036 (529 men and 507 women) apparently healthy Japanese subjects, aged 35–79 years, were analyzed. Weight, height, waist circumference and blood pressure were measured. Overnight fasting blood was collected to measure insulin and adiponectin levels. Homeostasis model assessment of insulin resistance (HOMA‐IR) was calculated to assess insulin resistance. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence intervals for a self‐reported history of kidney stones across tertiles of HOMA‐IR, insulin and adiponectin.Results:  Of the participants, 84 men (15.6%) and 35 women (6.9%) had a history of kidney stones. Age, body mass index, waist circumference, systolic and diastolic blood pressures, HOMA‐IR and insulin were significantly higher in women with than in women without kidney stones. There was no difference in adiponectin level between subjects with and without a history of kidney stones in either sex. Furthermore, a significant positive trend was observed in the age‐adjusted OR for a history of kidney stones across insulin tertiles (P‐value for trend = 0.04) in women.Conclusions:  For Japanese women, HOMA‐IR and insulin are associated with a history of kidney stones. The findings suggest that MetS components could increase the risk of kidney stones through subclinical hyperinsulinemia and insulin resistance.
Effect of sensory stimulation in rat barrel cortex, dorsolateral striatum and on corticostriatal functional connectivity
Authors: Syed Emilie C. J. , Sharott Andrew , Moll Christian K. E. , Engel Andreas K. , Kral Andrej 
Published: December 2010

AbstractThe striatum integrates sensory information to enable action selection and behavioural reinforcement. In the rat, a large topographical projection from the rat barrel cortex to widely distributed areas of the striatum is assumed to be an important structural component supporting these processes. The striatal sensory response is, however, not comprehensively understood at a network level. We used a 10‐Hz, 100‐ms air puff, allowing undamped movement of multiple whiskers, to look at functional connectivity in contralateral cortex and striatum in response to sensory stimulation. Simultaneous recordings of cortical and striatal local field potentials (LFPs) were made under isoflurane anaesthesia in 15 male Brown Norway rats. Four electrodes were placed in the barrel cortex while the dorsolateral striatum was mapped with a 500‐μm resolution, resulting in a maximum of 315 recording positions per animal. Significant event‐related responses were unevenly distributed throughout the striatum in 34.8% of positions recorded within this area. Only 10.3% of recorded positions displayed significant total power increases in the LFPs during the stimulation period at the stimulus frequency. This suggests that the responses seen in the LFPs are due to phase rearrangement rather than an amplitude increase in the signal. Analysis of corticostriatal imaginary coherence revealed stimulus‐induced changes in the functional connectivity of 12% of corticostriatal pairs, the sensory response of sparsely distributed neuronal ensembles within the dorsolateral striatum is reflected in the phase relationship between the cortical and striatal local fields.
Are all seeds equal? Spatially explicit comparisons of seed fall and sapling recruitment in a tropical forest
Authors: Swamy Varun , Terborgh John , Dexter Kyle G. , Best Benjamin D. , Alvarez Patricia , Cornejo Fernando 
Published: December 2010

Ecology Letters (2011) 14: 195–201AbstractUnderstanding demographic transitions may provide the key to explain the high diversity of tropical tree communities. In a faunally intact Amazonian forest, we compared the spatial distribution of saplings of 15 common tree species with patterns of conspecific seed fall, and examined the seed‐to‐sapling transition in relation to locations of conspecific trees. In all species, the spatial pattern of sapling recruitment bore no resemblance to predicted distributions based on the density of seed fall. Seed efficiency (the probability of a seed producing a sapling) is strongly correlated with distance from large conspecific trees, with a > 30‐fold multiplicative increase between recruitment zones that are most distant vs. proximal to conspecific adults. The striking decoupling of sapling recruitment and conspecific seed density patterns indicates near‐complete recruitment failure in areas of high seed density located around reproductive adults. Our results provide strong support for the spatially explicit predictions of the Janzen–Connell hypothesis.
Diversity, biological roles and biosynthetic pathways for sugar‐glycerate containing compatible solutes in bacteria and archaea
Authors: Empadinhas Nuno , da Costa Milton S. 
Published: December 2010

SummaryA decade ago the compatible solutes mannosylglycerate (MG) and glucosylglycerate (GG) were considered to be rare in nature. Apart from two species of thermophilic bacteria, Thermus thermophilus and Rhodothermus marinus, and a restricted group of hyperthermophilic archaea, the Thermococcales, MG had only been identified in a few red algae. Glucosylglycerate was considered to be even rarer and had only been detected as an insignificant solute in two halophilic microorganisms, a cyanobacterium, as a component of a polysaccharide and of a glycolipid in two actinobacteria. Unlike the hyper/thermophilic MG‐accumulating microorganisms, branching close to the root of the Tree of Life, those harbouring GG shared a mesophilic lifestyle. Exceptionally, the thermophilic bacterium Persephonella marina was reported to accumulate GG. However, and especially owing to the identification of the key‐genes for MG and GG synthesis and to the escalating numbers of genomes available, a plethora of new organisms with the resources to synthesize these solutes has been recognized. The accumulation of GG as an ‘emergency’ compatible solute under combined salt stress and nitrogen‐deficient conditions now seems to be a disseminated survival strategy from enterobacteria to marine cyanobacteria. In contrast, the thermophilic and extremely radiation‐resistant bacterium Rubrobacter xylanophilus is the only actinobacterium known to accumulate MG, and under all growth conditions tested. This review addresses the environmental factors underlying the accumulation of MG, GG and derivatives in bacteria and archaea and their roles during stress adaptation or as precursors for more elaborated macromolecules. The diversity of pathways for MG and GG synthesis as well as those for some of their derivatives is also discussed. The importance of glycerate‐derived organic solutes in the microbial world is only now being recognized. Their stress‐dependent accumulation and the molecular aspects of their interactions with biomolecules have already fuelled several emerging applications in biotechnology and biomedicine.
Genomic insights into the metabolic potential of the polycyclic aromatic hydrocarbon degrading sulfate‐reducing Deltaproteobacterium N47
Authors: Bergmann Franz , Selesi Draženka , Weinmaier Thomas , Tischler Patrick , Rattei Thomas , Meckenstock Rainer U. 
Published: December 2010

SummaryAnaerobic degradation of polycyclic aromatic hydrocarbons (PAHs) is an important process during natural attenuation of aromatic hydrocarbon spills. However, knowledge about metabolic potential and physiology of organisms involved in anaerobic degradation of PAHs is scarce. Therefore, we introduce the first genome of the sulfate‐reducing Deltaproteobacterium N47 able to catabolize naphthalene, 2‐methylnaphthalene, or 2‐naphthoic acid as sole carbon source. Based on proteomics, we analysed metabolic pathways during growth on PAHs to gain physiological insights on anaerobic PAH degradation. The genomic assembly and taxonomic binning resulted in 17 contigs covering most of the sulfate reducer N47 genome according to general cluster of orthologous groups (COGs) analyses. According to the genes present, the Deltaproteobacterium N47 can potentially grow with the following sugars including d‐mannose, d‐fructose, d‐galactose, α‐d‐glucose‐1P, starch, glycogen, peptidoglycan and possesses the prerequisites for butanoic acid fermentation. Despite the inability for culture N47 to utilize NO3‐ as terminal electron acceptor, genes for nitrate ammonification are present. Furthermore, it is the first sequenced genome containing a complete TCA cycle along with the carbon monoxide dehydrogenase pathway. The genome contained a significant percentage of repetitive sequences and transposase‐related protein domains enhancing the ability of genome evolution. Likewise, the sulfate reducer N47 genome contained many unique putative genes with unknown function, which are candidates for yet‐unknown metabolic pathways.