bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance analysis of pure paraffin wax as RFID tag substrate
Authors: Manzari S. , Babar A. A. , Ukkonen L. , Elsherbeni Atef Z. , Marrocco G. , Sydänheimo L. 
Published: December 2011

AbstractThe article presents an investigation of the performance of the Paraplast, a kind of pure paraffin wax, used as a substrate of RFID tag antennas operating at UHF RFID band. To achieve this purpose, two similar RFID tag antennas with same dimensions have been simulated, fabricated and tested. These include a simple dipole tag on a Rogers RT/Duroid 5880 substrate and on pure paraffin substrate. Because of the relatively close dielectric constant values, paraffin substrate is compared with Duroid RT5880. Paraffin wax can be considered as a low cost and low loss substrate. The main purpose in the future will be using paraffin as a passive temperature sensor, by exploiting the changes in molecular structure, volume and dielectric properties with temperature, especially near its melting point. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:442–446, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26592
Non‐viral transfection of goat germline stem cells by nucleofection results in production of transgenic sperm after germ cell transplantation
Authors: Zeng W. , Tang L. , Bondareva A. , Luo J. , Megee S.O. , Modelski M. , Blash S. , Melican D.T. , Destrempes M.M. , Overton S.A. , Gavin W.G. , Ayres S. , Echelard Y. , Dobrinski I. 
Published: December 2011

AbstractGermline stem cells (GSCs) can be used for large animal transgenesis, in which GSCs that are genetically manipulated in vitro are transplanted into a recipient testis to generate donor‐derived transgenic sperm. The objectives of this study were to explore a non‐viral approach for transgene delivery into goat GSCs and to investigate the efficiency of nucleofection in producing transgenic sperm. Four recipient goats received fractionated irradiation at 8 weeks of age to deplete endogenous GSCs. Germ cell transplantations were performed 8–9 weeks post‐irradiation. Donor cells were collected from testes of 9‐week‐old goats, enriched for GSCs by Staput velocity sedimentation, and transfected by nucleofection with a transgene construct harboring the human growth hormone gene under the control of the goat beta‐casein promoter (GBC) and a chicken beta‐globin insulator (CBGI) sequence upstream of the promoter. For each recipient, transfected cells from 10 nucleofection reactions were pooled, mixed with non‐transfected cells to a total of 1.5 × 108 cells in 3 ml, and transplanted into one testis (n = 4 recipients) by ultrasound‐guided cannulation of the rete testis. The second testis of each recipient was removed. Semen was collected, starting at 9 months after transplantation, for a period of over a year (a total of 62 ejaculates from four recipients). Nested genomic PCR for hGH and CBGI sequences demonstrated that 31.3% ± 12.6% of ejaculates were positive for both hGH and CBGI. This study provides proof‐of‐concept that non‐viral transfection (nucleofection) of primary goat germ cells followed by germ cell transplantation results in transgene transmission to sperm in recipient goats. Mol. Reprod. Dev. 79: 255–261, 2012. © 2011 Wiley Periodicals, Inc.
Glycolysis in preimplantation development is partially controlled by the Warburg Effect
Authors: Redel Bethany K. , Brown Alana N. , Spate Lee D. , Whitworth Kristin M. , Green Jonathan A. , Prather Randall S. 
Published: December 2011

AbstractGlucose metabolism in preimplantation embryos has traditionally been viewed from a somatic cell viewpoint. Here, we show that gene expression in early embryos is similar to rapidly dividing cancer cells. In vitro‐produced pig blastocysts were subjected to deep‐sequencing, and were found to express two gene variants that have been ascribed importance to cancer cell metabolism (HK2 and the M2 variant of PKM2). Development was monitored and gene expression was quantified in additional embryos cultured in low or high O2 (5% CO2, 5% O2, 90% N2 vs. 5% CO2 in air). Development to the blastocyst stage in the two atmospheres was similar, except low O2 resulted in more total and inner cell mass nuclei than high O2. Of the 15 candidate genes selected that are involved in glucose metabolism, only TALDO1 and PDK1 were increased in the low O2 environment. One paradigm that has been used to explain glycolysis under low oxygen tension is the Warburg Effect (WE). The WE predicts that expression of both HK2 and PKM2 M2 results in a slowing of glucose metabolism through the TCA cycle, thereby forcing the products of glycolysis to be metabolized through the pentose phosphate pathway and to lactic acid. This charging of the system is apparently so important to the early embryo that redundant mechanisms are present, that is, a fetal form of PKM2 and high levels of PDK1. Here, we set the framework for using the WE to describe glucose metabolism and energy production during preimplantation development. Mol. Reprod. Dev. 79: 262–271, 2012. © 2011 Wiley Periodicals, Inc.
An approximate dynamic programming method for multi‐input multi‐output nonlinear system
Authors: Huang Zhijian , Ma Jie , Huang He 
Published: December 2011

SUMMARYApproximate dynamic programming is a useful tool in solving multi‐stage decision optimal control problems. In this work, we first promote the action‐dependent heuristic dynamic programming method to multi‐input multi‐output control system by extending its action network to multi‐output form. The detailed derivation is also given. We then apply this method to the fluctuation control of a spark engine idle speed. An engine idling model is set up to verify the control effect of this method. Results here show that this method requires several iterations to suppress unbalanced combustion by manipulating spark ignition timing. This method provides an alternative for a simpler multi‐input multi‐output approximate dynamic programming scheme. Moreover, it has a faster iteration convergence effect. The derivation of this method also has a rigorous mathematical basis. Although illustrated for engines, this control system framework should also be applicable to general multi‐input multi‐output nonlinear system. Copyright © 2011 John Wiley & Sons, Ltd.
Could MDMA be useful in the treatment of post‐traumatic stress disorder?
Authors: Sessa Ben 
Published: December 2011

AbstractIn recent studies, 3,4‐methylenedioxymethylamphetamine (MDMA) has shown promise in the treatment of post‐traumatic stress disorder (PTSD) as an adjunct to post‐trauma psychological therapy. However, because of historical associations with its use as the recreational drug ecstasy, MDMA research remains a controversial subject. Dr Sessa discusses these controversies and describes a UK‐based MDMA/PTSD currently in development. Copyright © 2011 John Wiley & Sons, Ltd.
Managing bipolar depression: a therapeutic challenge?
Authors: Feetam Celia 
Published: December 2011

AbstractMost people with bipolar disorder first seek treatment for depressive rather than manic symptoms. However, effective management of bipolar depression remains a challenge. In this review, Celia Feetam highlights how bipolar depression differs from unipolar depression both in its characteristics and in the approach to its treatment. Copyright © 2011 John Wiley & Sons, Ltd.
Controlled radical polymerization of tert‐butyl acrylate at ambient temperature: Effect of initiator structure and synthesis of amphiphilic block copolymers
Authors: Sundaram Harihara Subramanian , Raghavachari Dhamodharan 
Published: December 2011

AbstractControlled and very rapid ambient temperature polymerization of tert‐butyl acrylate (tBA) via atom transfer radical polymerization (ATRP) and single electron transfer living radical polymerization (SET‐LRP) conditions is reported. Two initiators, one that would generate a secondary radical and another that would generate a primary radical, upon activation, are used. A very active catalyst CuBr/Me6TREN was found to initiate rapid polymerization whether it was the primary or the secondary initiator. The polymerization was well controlled and very rapid. The initiator that produces secondary initiating site is found to result in more rapid polymerization than the one that produces primary initiating site. To explore the possibility of rapid ambient temperature polymerization through the SET‐LRP mechanism, the polymerization was also carried out in the presence of DMSO. It was found that the polymerization was much faster compared to the bulk ATRP, without loss of control. Styrene was block copolymerized from PtBA macroinitiators and vice versa. In both the cases, block copolymers with controlled molecular weights were obtained. The tBA block of the polymer was selectively hydrolyzed to get amphiphilic block copolymers. This amphiphilic block copolymer was found to be useful in preparing stable cadmium sulfide (CdS) nanoparticulate dispersion. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Bereaved siblings' perception of participating in research—a nationwide study
Authors: Eilegård Alexandra , Steineck Gunnar , Nyberg Tommy , Kreicbergs Ulrika 
Published: December 2011

AbstractObjectiveThe objective of the present study is to examine bereaved siblings' perception of research participation.MethodsA Swedish nationwide study on avoidable and modifiable health care‐related factors in paediatric oncology among bereaved siblings who lost a brother or sister to cancer between the years 2000 and 2007 was conducted. Data are presented as proportions, and the differences between groups were statistically tested at the 5% significant level using Fisher's exact test.ResultsOut of 240 eligible siblings, 174 responded (73 %). None of the siblings (0/168) thought their participation would affect them negatively in the long term. However, 13% (21/168) stated it was a negative experience to fill out the questionnaire, whereas 84% (142/169) found it to be a positive experience. Women were more likely to report their participation as positive in a long‐term perspective compared with men (p = 0.018).ConclusionsNone of the bereaved siblings in this Swedish nationwide study anticipated any long‐term negative effect from their research participation. A majority reported it as positive to revisit their needs and experiences throughout their brother or sister's illness and death 2–9 years following the loss. We believe that the stepwise approach used in this study contributed to the high acceptance. Copyright © 2011 John Wiley & Sons, Ltd.
Quantification of impurity concentration in Cu2O and CuO via secondary ion mass spectrometry
Authors: Laufer Andreas , Reppin Daniel , Metelmann Hauke , Geburt Sebastian , Ronning Carsten , Leichtweiss Thomas , Janek Jürgen , Meyer Bruno K. 
Published: December 2011

AbstractSecondary ion mass spectrometry (SIMS) is a technically matured analysis technique for the investigation of depth and lateral distributions in solids. The “raw data” of a SIMS measurement provides only qualitative information. For quantification so‐called relative sensitivity factors (RSF) are mandatory. To our knowledge no RSFs have been determined for Cu2O and CuO so far. In this work the RSFs for 21 elements in Cu2O and 14 elements in CuO have been determined via ion implanted standards. For the RSF determination we present the plateau method (Section 3) for box‐like implantation profiles. This method provides a lower uncertainty in RSF value compared to the obtained uncertainty using single implantation profiles. In addition, we have estimated the electron affinities of NO2, AsO2 and SbO to 0.55, 2.7 and 2.85 eV, respectively. Unexpectedly, we observe for Cu2O and CuO nearly identical RSF values. This behaviour cannot be attributed to a change in chemical composition caused by the SIMS sputter process. Furthermore, the calculated RSFs have been used to determine the impurity concentrations of our sputtered copper oxide thin films.
DFT studies of cobalt hydride intermediate on cobaloxime‐catalyzed H2 evolution pathways
Authors: Jiang Yan‐Ke , Liu Jian‐Hui 
Published: December 2011

AbstractChemical, electrochemical, and photochemical methods all had been utilized to explore proton reduction catalysis by cobaloxime complexes. It was postulated in these studies that the initial step toward making H2 was protonation of CoI to form a CoIII hydride intermediate. However, in the following steps, different results from electrochemical studies had led to both monometallic and bimetallic pathways. In this article, theoretical computation method (BP86/6‐31G*) was firstly performed on possible cobalt hydride intermediates involved in the reactive pathway of cobaloxime‐catalyzed H2 evolution. The monometallic pathway B was excluded, both monometallic pathway A and bimetallic pathway were the possible process. However, the Gibbs free energy change for generation of H2 following monometallic pathway A was much more negative than that following bimetallic pathway. The calculation on monometallic pathway A indicated that the main driving force of the reaction (i) came from the step of the reduction of 11. The proton transfer steps were also studied in detail. The protonation of cobalt hydride intermediates could directly happen on the dimethylglyoximate part. All the results refer to gas‐phase calculations, not considering the solution. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Mass spectrometric quantification of AcSDKP‐NH2 in human plasma and urine and comparison with an immunoassay
Authors: Mesmin Cédric , Cholet Sophie , Blanchard Anne , Chambon Yann , Azizi Michel , Ezan Eric 
Published: December 2011

RATIONALEPrecise assessment of renal glomerular filtration rate (GFR) is essential for the early detection of chronic kidney disease. AcSDKP‐NH2, an analogue of the endogenous tetrapeptide AcSDKP, is not degraded in vivo and is freely filtered by the kidney and eliminated in urine; for that reason this analogue is an ideal candidate marker for the assessment of GRF after administration to humans. Proof‐of‐concept demonstration and lack of toxicity in animals have allowed an ongoing clinical study in which AcSDKP‐NH2 was administered intravenously at a dose of 100 µg and compared with currently available GFR markers. The use of the AcSDKP analogue in clinical practice requires that this novel marker be associated with an analytical method that combines specificity, robustness and high accuracy. We have developed a liquid chromatography/tandem mass spectrometry (LC/MS/MS) assay and compared it with an existing enzyme immunoassay (EIA) for AcSDKP‐NH2.METHODSHuman urine and plasma samples from the clinical study were analyzed by EIA and LC/MS/MS. Before LC/MS/MS assessment, AcSDKP‐NH2 was extracted using mixed‐mode cation‐exchange solid‐phase extraction cartridges. Chromatographic separation was performed by hydrophilic interaction liquid chromatography (HILIC), before analysis with an electrospray ionization triple quadrupole mass spectrometer.RESULTSMass spectrometry, through the use of an internal standard, tailored sample preparation and chromatographic separation, has better intra‐ and inter‐assay precision (accuracies between 95 and 101% with CVs < 8% for LC/MS/MS vs. accuracies between 90 and 115% with CVs <18% for EIA) and allows greater steadiness in intra‐subject concentrations during the infusion (4.4% for LC/MS/MS vs. 8.6% for EIA). Moreover, the LC/MS/MS assay circumvents matrix effects observed in certain instances for the EIA and which may reduce its accuracy.CONCLUSIONSAlthough the EIA can provide sufficient information in most subjects, the LC/MS/MS assay associated with this new marker should be the reference method. Copyright © 2011 John Wiley & Sons, Ltd.
Job Insecurity as a Predictor of Physiological Indicators of Health in Healthy Working Women: An Extension of Previous Research
Authors: Näswall Katharina , Lindfors Petra , Sverke Magnus 
Published: December 2011

AbstractJob insecurity has been linked to different negative outcomes, such as negative work attitudes and health problems, with most studies including self‐reported outcomes. Extending earlier research, the present study includes both self‐reported and physiological indicators of health and sets out to investigate whether higher levels of job insecurity are related to higher levels of allostatic load, higher levels of morning cortisol, more physician‐diagnosed symptoms of ill‐health and poorer self‐rated health. The study also investigated whether self‐rated health mediated the relation between job insecurity and physiological outcomes. This was cross‐sectionally studied in a cohort of Swedish women who participated in a large‐scale longitudinal study focusing on life span development and adaptation. The results showed that job insecurity was related to self‐rated health and morning cortisol, and, contrary to expectations, that job insecurity was unrelated to allostatic load and physician ratings, both directly and indirectly. The results indicate that, in healthy working women, job insecurity may be less detrimental to long‐term physiological health than originally hypothesized. Copyright © 2011 John Wiley & Sons, Ltd.
Layer‐by‐Layer Formation of Block‐Copolymer‐Derived TiO2 for Solid‐State Dye‐Sensitized Solar Cells
Authors: Guldin Stefan , Docampo Pablo , Stefik Morgan , Kamita Gen , Wiesner Ulrich , Snaith Henry J. , Steiner Ullrich 
Published: December 2011

AbstractMorphology control on the 10 nm length scale in mesoporous TiO2 films is crucial for the manufacture of high‐performance dye‐sensitized solar cells. While the combination of block‐copolymer self‐assembly with sol–gel chemistry yields good results for very thin films, the shrinkage during the film manufacture typically prevents the build‐up of sufficiently thick layers to enable optimum solar cell operation. Here, a study on the temporal evolution of block‐copolymer‐directed mesoporous TiO2 films during annealing and calcination is presented. The in‐situ investigation of the shrinkage process enables the establishment of a simple and fast protocol for the fabrication of thicker films. When used as photoanodes in solid‐state dye‐sensitized solar cells, the mesoporous networks exhibit significantly enhanced transport and collection rates compared to the state‐of‐the‐art nanoparticle‐based devices. As a consequence of the increased film thickness, power conversion efficiencies above 4% are reached.
Prenatal diagnosis and outcome of fetal posterior fossa fluid collections
Authors: Gandolfi Colleoni G. , Contro E. , Carletti A. , Ghi T. , Campobasso G. , Rembouskos G. , Volpe G. , Pilu G. , Volpe P. 
Published: December 2011

AbstractObjectiveTo evaluate the accuracy of fetal imaging in differentiating between diagnoses involving posterior fossa fluid collections and to investigate the postnatal outcome of affected infants.MethodsThis was a retrospective study of fetuses with posterior fossa fluid collections, carried out between 2001 and 2010 in two referral centers for prenatal diagnosis. All fetuses underwent multiplanar neurosonography. Parents were also offered fetal magnetic resonance imaging (MRI) and karyotyping. Prenatal diagnosis was compared with autopsy or postnatal MRI findings and detailed follow‐up was attempted by consultation of medical records and interview with parents and pediatricians.ResultsDuring the study period, 105 fetuses were examined, at a mean gestational age of 24 (range, 17–28) weeks. Sonographic diagnoses (Blake's pouch cyst, n = 32; megacisterna magna, n = 27; Dandy–Walker malformation, n = 26; vermian hypoplasia, n = 17; cerebellar hypoplasia, n = 2; arachnoid cyst, n = 1) were accurate in 88% of the 65 cases in which confirmation was possible. MRI proved more informative than ultrasound in only 1/51 cases. Anatomic anomalies and/or chromosomal aberrations were found in 43% of cases. Blake's pouch cysts and megacisterna magna underwent spontaneous resolution in utero in one third of cases and over 90% of survivors without associated anomalies had normal developmental outcome at 1–5 years. Isolated Dandy–Walker malformation and vermian hypoplasia were associated with normal developmental outcome in only 50% of cases.ConclusionPrenatal neurosonography and MRI are similarly accurate in the categorization of posterior fossa fluid collections from mid gestation. Blake's pouch cyst and megacisterna magna are risk factors for associated anomalies but when isolated have an excellent prognosis, with a high probability of intrauterine resolution and normal intellectual development in almost all cases. Conversely, Dandy–Walker malformation and vermian hypoplasia, even when they appear isolated antenatally, are associated with an abnormal outcome in half of cases. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Ultrasound is the optimal choice for guidance in difficult hysteroscopy
Authors: Kresowik J. D. , Syrop C. H. , Van Voorhis B. J. , Ryan G. L. 
Published: December 2011

AbstractObjectivesTo compare costs and complications associated with ultrasound‐guided hysteroscopy vs laparoscopy‐guided hysteroscopy vs hysteroscopy alone for the surgical repair of intrauterine septa and synechiae.MethodsThis was a retrospective cohort study. Charts of all patients undergoing reparative surgery for intrauterine synechiae or uterine septa at our academic institution between 2000 and 2008 were reviewed. A total of 159 procedures were included in the study, categorized into concurrent laparoscopic guidance (n = 69), ultrasound guidance (n = 52) or no guidance (n = 38). Data regarding billing, surgical case logs and complications were collected for these procedures. Using these data, complication rates and inflation‐adjusted charges were compared between the groups. Statistical analysis was performed using Fisher's exact test and Student's t‐test, as appropriate.ResultsA uterine perforation rate of 8.7% was observed with laparoscopic guidance vs 1.9% with ultrasound guidance (P = 0.12) and 5.3% with no guidance (P = 0.41). Analysis of billing data showed that average total costs were significantly less for ultrasound guidance than for laparoscopic guidance ($9124 vs $11 895, P < 0.001). Ultrasound guidance did not increase costs over hysteroscopy alone ($9124 vs $8242, P = 0.54).ConclusionReal‐time transabdominal ultrasound guidance during the resection of intrauterine synechiae or septa resulted in a trend towards reduced uterine perforation. Moreover, ultrasound guidance is less costly than laparoscopic guidance and adds no additional cost over hysteroscopy alone. Taken together, transabdominal ultrasound guidance is the optimal means of intraoperative guidance for the resection of uterine synechiae and septa. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.