bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indole derivatives as agrochemicals
Authors: Andreani Aldo , Rambaldi Mirella 
Published: April 2009

AbstractThe synthesis of indole derivatives prepared as potential agrochemicals is reported. The 1‐carbamoyl‐2‐indolinones 5 showed moderate nematicidal activity while the acylureas 8 were weak insecticides. The 2,4‐dinitrophenyl oxime 11c proved to be a potent herbicide with a narrow spectrum of activity.
Derivatives of 3‐(2‐hydroxyethyl)2‐benzothiazolinone and related compounds
Authors: D'Amico John J. , Bellinger Frederic G. 
Published: April 2009

AbstractThe reaction of the appropriate 2‐benzothiazolinone with 2‐chloroethanol or 3‐chloropropanol under basic conditions afforded 3‐(2‐hydroxyethyl or 3‐hydroxypropyl)‐2‐benzothiazolinone and related compounds 1–7. The reaction of the alcohols 1,4, 5 or 7 with potassium hydroxide and excess carbon disulfide furnished the potassium salts of xanthic acid 8–11 which upon oxidation gave the disulfides 12–15. Esters of xanthic acid 16–23 were prepared by the reaction of 8 or 11 with various halogen compounds. Esters of acetic acid 24–28 were prepared by the reaction of the appropriate 2‐benzothiazolinone with 2‐bromoethyl acetate under basic conditions. Esterification of 1 with various acids afforded the esters 25, 29–32.
β‐Carbolines derived from β‐methyltryptophan and a stereoselective synthesis of (2RS,3SR)‐β‐methyltryptophan methyl ester
Authors: Behforouz Mohammad , Zarrinmayeh Hamideh , Ogle Mark E. , Riehle Tammy J. , Bell Frank W. 
Published: April 2009

AbstractThe methyl ester of isomer A of β‐methyltryptophan (2SR,3RS; 2A) was stereoselectively prepared by an efficient modified method through the reaction of a‐methyl‐N‐(1‐Methylethyl)‐1H‐indole‐3‐methanamine (3) with methyl nitroacetate to give the desired nitro compound as a mixture of two racemates 5A, and 5B. During the recrystallization process epimerization occurred and only racemate 5A crystallized out. Catalytic hydrogenation of 5A in the presence of acid stereoselectively yielded the desired amino acid ester 2A. Pictet‐Spengler condensation of 2A with aldehydes under aprotic conditions followed by dehydrogenation gave excellent yields of β‐carbolines 7a‐i, (R = methyl, ethyl, acetyl, phenyl, pyridine‐2‐yl, furan‐2‐yl, quinoline‐2‐yl, styryl, phenethyl). Also β‐carbolines 7a,b,i were synthesized by the Pictet‐Spengler condensation of (3‐meth‐yltryptophan under acidic aqueous conditions followed by esterification and dehydrogenation.
Conformational behaviour of non‐fused biheterocycles. Part XV. Isomeric phenylisoxazoles
Authors: Russo Nino , Toscano Marirosa , Barone Vincenzo 
Published: April 2009

AbstractThe conformational behaviour of isomeric phenylisoxazoles has been investigated at the STO‐3G level optimizing the most significant geometrical parameters. The energy minima of the two isomers having an heteroatom in an ortho position correspond to planar structures, whereas the 4‐isomer has a twisted equilibrium conformation. This confirms that HH non‐bonded repulsions are stronger than (lone‐pair)‐H ones. The similar conformational behaviour of corresponding phenylfurans and phenylisoxazoles shows that the second heteroatom has a negligible effect and that the conformational behaviour of non‐fused biheterocycles is dictated by the nature of the ortho substituents.
Studies on pyrazines. 17.. An efficient synthesis of pteridine‐6‐carboxylic acids
Authors: Sato Nobuhiro , Saito Noriko 
Published: April 2009

Abstract2,4‐Diaminopteridine‐6‐carboxylic acid (1) and pterin‐6‐carboxylic acid (2) were prepared by permanganate oxidation of the corresponding 6‐(2‐furyl)‐substituted pteridines under much milder conditions. Several attempts to cleave the furan ring with other oxidizing agents are also described.
Synthesis of 2,3‐quinolinedicarboxylic acid
Authors: Maulding Donald R. 
Published: April 2009

AbstractA new procedure for making 2,3‐quinolinedicarboxylic acid (6), starting with aniline and maleic anhydride has been developed. Evidence for the formation of 2‐anilino‐3‐formyl‐N‐phenylmaleimide (7) in the cyclization of S‐phenylimino‐4‐dimethylaminomethylene‐N‐phenylsuccinimide (4a) to N‐phenylacridinimide (5a) is presented.
Large‐ring, chromogenic benzocrown compounds
Authors: Czech Anna , Czech Bronislaw P. , Bartsch Richard A. 
Published: April 2009

AbstractEight novel, large‐ring chromogenic benzocrown compounds have been synthesized. Two incorporate 19‐and 20‐membered crown units with six ring oxygens. Six others contain large rings ranging from 21‐crown‐7 to 30‐crown‐10. For all six benzocrown compounds, the 4′‐(2″,4″‐dinitro‐6″‐trifluoromethylphenyl)amino group was employed as the chromogenic unit. In addition, 4′‐picrylamino and 4′‐(2″,6″‐dinitro‐4″‐trifluoromethylphenyl)amino groups were also attached to benzo‐21‐crown‐7.
1,2,3‐thiadiazoles. I. Synthesis of sodium (or potassium) 1,2,3‐thiadiazole‐4‐thiolates via thiocarbazonate esters and N‐acylthiohydrazonate esters
Authors: Lee Ving J. , Curran William V. , Fields Thomas F. , Learn Keith 
Published: April 2009

AbstractA general synthesis of 1,2,3‐thiadiazole‐4‐thiolates 1 and their derivatives 2–3 by an extension of the Hurd‐Mori 1,2,3‐thiadiazole synthesis is described. Treatment of methyl (or ethyl) [1‐(alkylthio)alkylidene]hydrazinocarboxylates 11 (thiocarbazonate esters) or other N‐acylthiohydrazonate esters [Y = ureido (12) or arenesulfonyl (13)] with thionyl chloride affords 2–3 efficiently. Intermediates 11–13 are readily obtained from the N2‐thioacylcarbazates 8, N3‐thioacylsemicarbazides 9, or N2‐thioacyl‐N1‐(p‐toluenesulfonyl)hydrazides 10, respectively, by S‐alkylation. Physicochemical properties of the 1,2,3‐thiadiazoles 1–3 and N‐acylthiohydrazonate esters 11–13 are also described.
Functionalization and cyclization reactions of 4‐benzoyl‐1,5‐diphenyl‐ 1H‐pyrazole‐3‐carboxylic acid
Authors: Akcamur Yunus , Sener Ahmet , Ipekoglu Alemdar Mustafa , Kollenz Gert 
Published: April 2009

AbstractThe 1H‐pyrazole‐3‐carboxylic acid 2 or its remarkably stable acid chloride 3 can easily be converted into the corresponding ester or amide derivatives 4 or 5, respectively, from reaction with alcohols or N‐nucleophiles. Pyrazolo[3,4‐d]pyridazines 6a,b are obtained from cyclocondensation reactions of the pyrazoles 2 and 3, respectively, with phenylhydrazine or hydrazine hydrate, while 6c is formed in an one‐pot procedure from the furan‐2,3‐dione 1 and hydrazine hydrate.
Aminoacids in the synthesis of heterocyclic systems. The synthesis of methyl 2‐acetylamino‐3‐dimethylaminopropenoate and 2‐(N‐methyl‐N‐trifluoroacetyl)amino‐3‐dimethylaminopropenoate and their application in the synthesis of heterocyclic compounds
Authors: Kralj Lucija , Hvala Aleš , Svete Jurij , Golič Ljubo , Stanovnik Branko 
Published: April 2009

AbstractMethyl (Z)‐2‐acetylamino‐3‐dimethylaminopropenoate (3) was prepared from N‐acetylglycine (1), which was converted with N,N‐dimethylformamide and phosphorus oxychloride into 4‐dimethylaminomethylene‐2‐methyl‐5(4H)‐oxazolone (2), followed by treatment with methanol in the presence of potassium carbonate, into 3. The compound 3 was shown to be a versatile reagent in the synthesis of various heterocyclic systems. With N‐nucleophiles, such as heterocyclic amines 4, either methyl 2‐acetylamino‐3‐heteroarylaminopropenoates 5 or fused pyrimidinoncs 6 were formed, dependent on the reaction conditions and/or heterocyclic substituents: C‐nuclcophiles with an active or potentially active methylene group, such as 1,3‐dicarbonyl compounds 7, 8 and 9, substituted phenols 10a,b, naphthols 11, 12a‐c, and substituted coumarin 13a, afforded substituted pyranones 20 and 22, and fused pyranones 21, 23–26. The nitrogen containing heterocycles 14–19 produced pyranoazines 27–31 and pyranoazole 32. In all of these systems the acetylamino group is attached at position 3 of the newly formed pyranone ring. The orientation around the double bond for methyl (Z)‐2‐(N‐methyl‐N‐trifluo‐roacetyl)‐3‐dimethylaminopropenoate (36) was established by X‐ray analysis.
Positive ions and negative ions fab (fast atom bombardment) mass spectrometry of some bisazolium salts
Authors: Cabildo Pilar , Claramunt Rosa , Lavandera José Luis , Sanz Dionisia , Elguero Jose , Enjalbal Christine , Aubagnac Jean‐Louis 
Published: April 2009

AbstractSignificant information on the structure of various bisazolium salts of the type CA2 (C++ 2A−) were revealed by the study of the FAB spectra of their positive and negative ions. Thus only one spectrum, whatever it consists of the positive or of the negative ions spectrum, enables the identification of the cation C++ and of the anion A−. Moreover, the same information are collected from the CAD spectrum of the adduct ion CA+ allowing the identification of such a compound in a mixture.
Ethyl (4‐N‐acylaminopyridin‐3‐yl)glyoxylate and 5‐azaisatin as new synthons for a route to various new polyheterocycles
Authors: Rivalle Christian , Bisagni Emile 
Published: April 2009

AbstractFrom 4‐N‐protected‐aminopyridines which were functionalized at their 3‐position, 5‐azaisatin and equivalent synthons where obtained. Via the use of the Pfitzinger reaction, these compounds provided an easy route to new and various polyheterocyclic compounds.
The reaction of 3,5‐dichloro‐2,4,6‐trimethylbenzonitrile oxide with chiral fluoro‐substituted allyl sulfoxides
Authors: Bravo Pierfrancesco , Bruché Luca , Seresini Paolo , Zanda Matteo , Arnone Alberto 
Published: April 2009

AbstractThe title reaction allowed the synthesis, with total regio‐ and moderate stereo‐selectivity, of chiral fluorosubstituted 4,5‐dihydroisoxazoles.
Kinetic study on the synthesis of some benzo[g]quinoxalin‐2(1H)‐one derivatives
Authors: Rodrigo Gabriela A. , Renou Sergio G. , Bekerman Diana G. , Abasolo M. Inés , Fernández Beatriz M. 
Published: April 2009

AbstractSome novel 3‐substituted benzoquinoxalinones [R = H, CH3, C6H5, (CH2)2COOH] were synthesized by the Hinsberg reaction between 2,3‐diaminonaphthalene and several α‐dicarbonyl compounds. The course of the reactions was followed by the second uv/visible Derivative Spectroscopy Method at different pH values (‐0.89 to 9.0) and also in organic solvents at 25°. The compound non‐substituted at C‐3 was the only one that could be obtained in every media in good yields (80%), having pseudo first‐order anelation rate constants of relative high values (1 × 10−1 — 1 × 10−2 min−1). On the other hand, only methanol could be used as the organic solvent for the synthesis of all of the other compounds; aqueous media always provided better results. In the 3‐methyl derivative, as well as in the 3‐phenyl derivative the change of the reaction pH medium modified the stoichiometry of the anelation, turning a non‐quantitative reaction into a quantitative one. This is explained by a change in the mechanism of the reaction on going to lower hydrogen concentrations, a fact that was supported by complementary quantitative hptlc experiments. In general, pseudo first‐order rate constants for the anelation were one or two logarithmic units lower than those of the non‐substituted compound (RC‐3 = H), but yields were above 60% in every case. A reaction scheme is presented which includes a probable mechanism.
Use of sulfur derivatives as an ortho directing group for the metalation of diazines. Metalation of diazines. XVIII
Authors: Turck Alain , Plé Nelly , Pollet Paméla , Mojovic Ljubica , Duflos Jack , Quéguiner Guy 
Published: April 2009

AbstractThe metalation of thioethers, methyl and phenyl sulfoxides and sulfones of pyrazine and pyridazine has been performed. Methyl sulfoxides and sulfones were first metalated on the methyl group. The ortho directing effect of thioethers, sulfoxides and sulfones have been compared with the methoxy group. The sulfoxides were shown to be very good ortho directing groups.
Molecular structure and electronic spectrum of ellagic acid: Semiempirical molecular orbital calculations
Authors: Sato Tsuguo , Kataoka Masahiro 
Published: April 2009

AbstractThe molecular structure of ellagic acid has been optimized by using PM3 semiempirical MO method. Ellagic acid has been calculated to be planar with the molecular symmetry of C2h. The lactone carbonyl groups are not tilted from the molecular plane. CNDO/S MO method has been used to interpret the experimental uv‐vis spectroscopic data. The results of the PM3 and CNDO/S calculations have been in good agreement with the experimental data.
Synthesis of some piperazinylpyrazolo[3,4‐b]pyridines as selective serotonin re‐uptake inhibitors
Authors: Shutske Gregory M. , Roehr Joachim E. 
Published: April 2009

AbstractA number of 3‐substituted 6‐piperazinylpyrazolo[3,4‐b]pyridines were synthesized from 2,6‐difluoropyridine by directed ortho metallation and sequential intra‐ and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3‐position showed activity as selective serotonin re‐uptake inhibitors.
Furopyridines. XXIV. Nitration, chlorination, acetoxylation and cyanation of 2,3‐dihydrofuro[2,3‐b]‐, ‐[3,2‐b]‐, ‐[2,3‐c]‐ and ‐[3,2‐c]pyridine N‐Oxides
Authors: Shiotani Shunsaku , Kurosaki Masahide , Taniguchi Katsunori , Moriyama Miwa 
Published: April 2009

AbstractNitration of 2,3‐dihydrofuro[3,2‐b]‐ N‐oxide 3b and ‐[2,3‐c]pyridine N‐oxide 3c afforded the nitropyridine compounds 4b, 5b and 6 from 3b and 4c, 5c, 5′c and 7 from 3c, while ‐[2,3‐b]‐ N‐oxide 3a and ‐[3,2‐c]pyridine N‐oxide 3d did not give the nitro compound. Chlorination of 3b and 3c with phosphorus oxychloride yielded mainly the chloropyridine derivatives 15b, 15′b from 3b and 15c and 15′c from 3c, whereas 3a and 3d gave pyridine derivatives formed through fission of the 1–2 ether bond of the furo‐pyridines 13a, 14 and 13d. Acetoxylation of 3b and 3c gave 3‐acetoxy derivatives 18b and 18c and the parent compound 1b and 1c. Acetoxylation of 3a yielded compounds formed through fission of the 1–2 bond 16 and 17 and 3d gave furopyridones 19 and 19′. Cyanation of 3b and 3c yielded mainly the cyanopyridine compounds 20b, 20c and 20′c. Cyanation of 3a and 3d gave the cyanopyridine compounds 20a, 20d and 20′d accompanying formation of the pyridine derivatives 21a, 21d and 21′d.
Synthesis of substituted 1‐benzyl‐2,4,6‐triphenyl‐2,3‐dihydro‐pyrazolo [3,4‐b] [1,4]diazepines
Authors: Insuasty Braulio , Rodriguez Ricaurte , Quiroga Jairo , Martinez Roberto , Angeles Enrique 
Published: April 2009

AbstractThe acid catalyzed condensation of 4,5‐diaminopyrazoles and chalcones gave the hitherto unknown 1‐benzyl‐2,4,6‐triphenyl‐2,3‐dihydropyrazolo[3,4‐b][1,4]diazepines derivatives. The structure of all products was supported by ir, 1H and 13C‐nmr and mass spectra.
Synthesis of 6‐phenyl‐atevirdine
Authors: Troschütz Reinhard , Karger Alexander 
Published: April 2009

AbstractThe synthesis of 6‐phenyl‐atevirdine (17), a lipophilic derivative of the potent HIV‐1 reverse transcriptase inhibitor atevirdine (1), is described. The title compound was prepared from dithioacetale 2 via keteneaminal 4 and the nitropyridine derivative 10. Unexpectedly, no anti HIV activity was observed for the novel atevirdine derivative 17. The key intermediates 6, 8 and 10 could also be prepared from keteneaminal 18 via chloropyridines 22–24.
Preparation and NMR spectra of substituted 2‐phenyl‐5,5‐dialkylimidazolinones
Authors: Sedlák Miloš , Halama Aleš , Mitaš Petr , Kaválek Jaromír , Macháček Vladimír 
Published: April 2009

AbstractEighteen substituted 2‐phenyl‐5,5‐dialkylimidazolinones 2 have been prepared by cyclizations of substituted 2‐(N‐benzoylamino)alkanamides 1. The cyclization of methylamides 1 proceeds at room temperature whereas primary amides are cyclized on boiling. The 1H and 13C nmr spectra of the imidazolinones are presented and the changes in their spectra connected with their protonation in hexadeuteriodimethyl sulfoxide‐trifluoroacetic acid mixtures are discussed.
Isopropenyldihydrofuran derivatives. Preparation and reactions of some isopropenyldihydrofurandicarboxylates
Authors: Yamaguchi Seiji , Sugioka Yosbihiko , Ishida Miwa , Yokoyama Hajime , Hirai Yoshiro 
Published: April 2009

AbstractDiethyl 5‐isopropenyl‐4,5‐dihydrofuran‐2,3‐dicarboxylate 1a and methyl 5‐isopropenyl‐3‐methoxy‐carbonyl‐4,5‐dihydrofuran‐2‐acetate 2a were prepared by cylization of diethyl 2‐oxosuccinate or dimethyl 3‐oxoglutarate with (E)‐1,4‐dibromo‐2‐methyl‐2‐butene. Their chemical properties were studied.
A convenient synthesis of 8‐substituted indolizines as precursors to 5‐substituted cycl{3.2.2}azine derivatives
Authors: Smith Jonathan O. , Mandal Braja K. 
Published: April 2009

AbstractThe synthesis of 8‐substituted indolizines is described via a two step process in which a 1,4‐diketone, containing a rerf‐butyl group, is cyclocondensed with a trialkylsilyl protected pyrrole to provide 5,8‐disubstituted indolizines in higher yields than the identical reaction with unprotected pyrrole. Cleavage of the tert‐butyl group from the indolizine 5‐position, by treatment with 85% phosphoric acid, provides 8‐substituted indolizines in good yields. Treatment of 8‐substituted indolizines with dimethyl acetylenedicarboxylate, in the presence of palladium‐on‐carbon, provides novel 5‐substituted cycl{3.2.2) derivatives.
The synthesis and transformation of ethyl 2‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)amino‐3‐dimethylaminopropenoate. A new synthesis of 2,3,4‐trisubstituted pyrroles
Authors: Malešič Mateja , Krbavčič Aleš , Golobič Amalija , Golič Ljubo , Stanovnik Branko 
Published: April 2009

AbstractThe synthesis of ethyl 2‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)amino‐3‐dimethylarninopropenoate (4) from benzoylacetone (1) via 3‐dimethylarninomethylenebenzoylacetone (2) and ethyl N‐(2‐acetyl‐2‐benzoyl‐1‐ethenyl)glycinate (3) and its transformation into 4‐benzoyl‐2‐ethoxycarbonyl‐3‐methylpyrrole (9) is described. Cyclization of 4 into 9 represents a new synthesis of polysubstituted pyrroles.
Synthesis of the novel thieno[4,3,2‐ef][1,4]benzoxazepine ring system: 4,5‐Dihydro‐3‐(4‐pyridinyl)thieno[4,3,2‐ef][1,4]benzox‐azepine maleate
Authors: Tomer John D. , Shutske Gregory M. , Friedrich Dirk 
Published: April 2009

Abstract4,5‐Dihydro‐3‐(4‐pyridinyl)‐thieno[4,3,2‐ef][1,4]benzoxazepine maleate 2 has been synthesized from 3‐amino‐4‐fluorobenzo[fc]thiophene by employing an intramolecular nucleophilic aromatic fluoride displacement. In the presence of strong base and heat, 2 rearranges to form the isomeric hemiaminal, 3,4‐dihydro‐4‐methyl‐3‐(4‐pyridinyl)thieno[4,3,2‐ef][1,3]benzoxazine 10. A proposed mechanism for this rearrangement is discussed.
Synthesis of dendritic polypyridines using divergent methodology
Authors: Chessa Gavino , Scrivanti Alberto 
Published: April 2009

AbstractThe synthesis of dendritic polypyridines is described. The dendrimers were prepared by a divergent approach using diethl 4‐hydroxypyridine‐2,6‐dicarboxylate 1 and 4‐hydroxy‐2,6‐bis(acetoxymethyl)pyridine 6 as building blocks. The transformation of the surface functionalities of the second generation dendrimer led to imperfections which did not allow us to further increase the size of the macromolecule.
A back‐trajectory and air mass climatology for the Northern Shenandoah Valley, USA
Authors: Hondula David M. , Sitka Luke , Davis Robert E. , Knight David B. , Gawtry Stephen D. , Deaton Michael L. , Lee Temple R. , Normile Caroline P. , Stenger Philip J. 
Published: April 2009

AbstractSynoptic‐scale air quality climatologies can often be categorized into trajectory methods based on air parcel movement or air mass approaches that are primarily dictated by thermal and moisture conditions. Here, we examine the relationship between these two essentially independent methods of synoptic‐scale climate classification: 72‐h Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model back‐trajectories and the Spatial Synoptic Classification (SSC) of air masses for Martinsburg, West Virginia, located at the northern end of the Shenandoah Valley, from 1997 to 2006. Statistically significant differences exist between trajectory groups across the six SSC air mass types within each season and between seasons within each air mass type.Further examination of the trajectory distributions reveals a high degree of overlap between trajectories associated with different air mass types. In some cases, up to 50% of one air mass's trajectories are statistically closer to the trajectories of a different air mass type. Accordingly, air mass alone cannot be used to identify specific source regions of pollutants. This suggests that, while an air mass classification system can be used to identify general flow patterns, the integration of both thermodynamic and air‐flow variables in a synoptic classification should provide information that is not discernible from either method independently. The inclusion of both back‐trajectory and air mass information represents the suite of environmental conditions that may enhance or suppress pollutant concentrations in the Shenandoah Valley better than using either measure independently. Copyright © 2009 Royal Meteorological Society
IgE‐mediated fungal allergy in allergic fungal sinusitis
Authors: Pant Harshita , Schembri Mark A. , Wormald Peter J. , Macardle Peter J. 
Published: April 2009

AbstractThis review will address the current knowledge of the pathogenic mechanisms in allergic fungal sinusitis (AFS) and the basis for the current classification of a subgroup of chronic rhinosinusitis patients. Special attention is directed to the role of immunoglobulin E (IgE)‐mediated fungal allergy in the pathogenesis of AFS. Concepts relating to the mucosal inflammatory response are introduced, as a knowledge of the reactions of the sinus mucosal cells can lead to a better understanding of the mechanisms perpetuating and maintaining the chronic inflammation. Laryngoscope, 2009
Office‐based sclerotherapy for benign parotid lymphoepithelial cysts in the HIV‐positive patient
Authors: Berg Eric E. , Moore Charles E. 
Published: April 2009

AbstractObjective:To determine the efficacy of sodium morrhuate injection therapy in the control of benign lymphoepithelial cysts of the parotid gland.Study Design:Retrospective review.Methods:The medical records of human immunodeficiency virus (HIV)‐positive patients who presented to an indigent care hospital for the evaluation and management of benign lymphoepithelial cysts of the parotid gland are reviewed. Cyst laterality, aspiration and injection volumes, and noted complications were recorded. When applicable, elapsed time between recurrent interventions was recorded.Results:Medical records were available for a total of nine patients who underwent aspiration and injection of 34 cysts. Five of the nine patients required therapy for additional cyst formation an average of 11.8 months after initial intervention. There have been no known instances of facial nerve or parotid gland injury, and the only recorded postprocedure complaints were pain and mild edema.Conclusions:While multiple cysts may arise and serial intervention may be required, we believe that in association with broader clinical experience, the data presented here support aspiration and sodium morrhuate injection as a safe, minimally invasive, and efficacious technique in the treatment of benign lymphoepithelial cysts of the parotid gland in the HIV‐positive population. Laryngoscope, 2009