bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacokinetic study of a novel sonosensitizer chlorin‐e6 and its sonodynamic anti‐cancer activity in hepatoma‐22 tumor‐bearing mice
Authors: Shi Haitao , Liu Quanhong , Qin Xiaofei , Wang Pan , Wang Xiaobing 
Published: August 2011

ABSTRACTPurposeThe sonodynamically induced anti‐tumor effect of chlorin‐e6 (Ce6) was studied in mice bearing hepatoma‐22 solid tumors.MethodsIn order to determine the optimum timing of ultrasound exposure after administration of Ce6, the Ce6 concentrations in plasma, skin, muscle and tumor were estimated by measuring the fluorescence intensity of tissue extractions with a fluorescence photometer based on the standard curve. A three‐dimensional optical imaging system (IVIS spectrum) was used further to characterize the distribution of Ce6 in H‐22 tumor. The anti‐tumor effects were estimated by measuring tumor size after sonodynamic therapy.ResultsSimilar pharmacokinetic trends of Ce6 in mice were observed either by fluorescence spectrophotometry or by bio‐optical imaging. The results also demonstrated that Ce6 has a preferential localization in tumors, but low accumulation and rapid clearance in normal tissues. The results of anti‐tumor effects revealed that at an ultrasound intensity of 4 W/cm2 and a Ce6 dose of ≥10 mg/kg, a significant synergistic effect of ultrasound combined with Ce6 was observed, reducing the tumor volume significantly.ConclusionChlorin‐e6 is a potential sonosensitizer for fluorescence imaging as well as for sonodynamic therapy for cancer. The anti‐tumor effect of ultrasound could be enhanced in the presence of Ce6, which might be involved in a sonochemical mechanism. Copyright © 2011 John Wiley & Sons, Ltd.
ChemInform Abstract: Contribution of Disulfide S22‐ Anions to the Crystal and Electronic Structures in Ternary Sulfides, Ba12In4S19, Ba4M2S8 (M: Ga, In).
Authors: Liu Ji‐Wei , Wang Peng , Chen Ling 
Published: August 2011

AbstractThe title compounds are prepared by solid state reactions of the elements using about 20% excess of sulfur (850 °C, 40—95% yields).
ChemInform Abstract: Lithium Migration at High Temperatures in Li4Ti5O12 Studied by Neutron Diffraction.
Authors: Laumann Andreas , Boysen Hans , Bremholm Martin , Fehr Thomas K. , Hoelzel Markus , Holzapfel Michael 
Published: August 2011

AbstractThe structure of the spinel‐type title compound, an anode material for batteries, is characterized by neutron powder diffraction from room temperature to 1100 °C.
ChemInform Abstract: K3B6O10Cl: A New Structure Analogous to Perovskite with a Large Second Harmonic Generation Response and Deep UV Absorption Edge.
Authors: Pan Shilie , et al. et al. 
Published: August 2011

AbstractSingle crystals of the title compound are prepared by reaction of KCl and H3BO3 in a KF/PbO flux (KF:KCl:PbO:H3BO3 = 2:1:2:6, Pt crucible, 650 °C, 15 h).
ChemInform Abstract: [HxTeV9O28](5‐x)‐ (x = 1 and 2): Vanadotellurates with Decavanadate Structure.
Authors: Konaka Saki , Ozawa Yoshiki , Shonaka Takahiro , Watanabe Shinta , Yagasaki Atsushi 
Published: August 2011

AbstractThe new vanadotellurates (III) and (IV) (crude yield given in gram) are characterized by single crystal XRD and DFT calculations.
ChemInform Abstract: The Synthesis of a New Nitrogen Joined N‐PEG‐TsDPEN Ligand and Its Application in Asymmetric Transfer Hydrogenation of Ketones in Neat Water.
Authors: Shan Wenjun , Meng Fanchao , Wu Yinuo , Mao Fei , Li Xingshu 
Published: August 2011

AbstractOptically active diamine PAP with a polyethylene glycol chain attached to one nitrogen is a highly active and enantioselective ligand in the transfer hydrogenation of aromatic ketones.
ChemInform Abstract: Enantioselective Pd‐Catalyzed Hydrogenation of Enesulfonamides.
Authors: Yu Chang‐Bin , Gao Kao , Wang Duo‐Sheng , Shi Lei , Zhou Yong‐Gui 
Published: August 2011

AbstractEfficient catalytic systems are found for the synthesis of chiral sultams (II) and (IV) by an asymmetric hydrogenation of endo‐cyclic enesulfonamides (I) and exo‐cyclic enesulfonamides (III), respectively.
ChemInform Abstract: Sequential ATRA/Reductive Cyclopropanation Reactions with a Ruthenium Catalyst in the Presence of Manganese.
Authors: Fernandez‐Zumel Mariano A. , Buron Charlotte , Severin Kay 
Published: August 2011

AbstractAtom‐transfer radical addition reactions of olefins with ethyl dichloroacetate (II) result in the formation of dichlorobutanoates (III).
ChemInform Abstract: Asymmetric Transfer Hydrogenation of Acetophenone Derivatives with Novel Chiral Phosphinite Based η6‐p‐Cymene/Ruthenium(II) Catalysts.
Authors: Aydemir Murat , Meric Nermin , Baysal Akin , Turgut Yilmaz , Kayan Cezmi , Seker Sevil , Togrul Mahmut , Guemguem Bahattin 
Published: August 2011

AbstractRuthenium complexes (I) are readily prepared and their structures are supported by 1H and 13C NMR data.
ChemInform Abstract: Phenalenyl‐Based Ligand for Transition Metal Chemistry: Application in Henry Reaction.
Authors: Mukherjee Arup , Sen Tamal K. , Mandal Swadhin K. , Kratzert Daniel , Stalke Dietmar , Doering Alexander , Schulzke Carola 
Published: August 2011

AbstractThe new copper complex PHECU is shown to catalyze the addition reaction of nitromethane to aromatic aldehydes.
ChemInform Abstract: Stereochemically Controlled Asymmetric 1,2‐Reduction of Enones Mediated by a Chiral Sulfoxide Moiety and a Lanthanum(III) Ion.
Authors: Motohashi Shigeyasu , Nagase Kouichi , Nakakita Toshinori , Matsuo Takeshi , Yoshida Yoshikazu , Kawakubo Takashi , Miura Motofumi , Toriyama Masaharu , Barybin Mikhail V. 
Published: August 2011

AbstractReduction of (Z)‐β‐sulfinyl enones with NaBH4/ LaCl3·7H2O allows efficient access to enantiomerically pure allylic alcohols after desulfuration.
ChemInform Abstract: Highly Efficient Synthesis of Multisubstituted 2‐Acyl Furans via PIFA/I2‐Mediated Oxidative Cycloisomerization of cis‐2‐En‐4‐yn‐1‐ols.
Authors: Du Xiangwei , Chen Haoyi , Chen Yifeng , Chen Jingjin , Liu Yuanhong 
Published: August 2011

AbstractCombination of a hypervalent iodine(III) reagent, molecular iodine, and a base gives rise to an oxidative cycloisomerization of cis‐enynols, enabling the synthesis of 2‐acyl furans with diverse substitution patterns in a regioselective manner under mild conditions.
ChemInform Abstract: Selectivity Manipulation of Bicyclization Reactions of 1,5‐Bis(1,2‐allenylketone)s: Pd versus Rh and Electronic Effect.
Authors: Deng Youqian , Fu Chunling , Ma Shengming 
Published: August 2011

AbstractThe rhodium‐catalyzed double cyclization affords furan‐fused bicyclic products.
ChemInform Abstract: Dinuclear Zinc Catalyzed Asymmetric Friedel—Crafts Amidoalkylation of Indoles with Aryl Aldimines.
Authors: Wang Bei‐Lei , Li Nai‐Kai , Zhang Jin‐Xin , Liu Guo‐Gui , Liu Teng , Shen Qi , Wang Xing‐Wang 
Published: August 2011

AbstractAsymmetric Friedel—Crafts amidoalkylation of indoles (I) and (VI) with aryl aldimines (II), (IV) or (VII) is efficiently catalyzed by Trost′s dinuclear zinc—bis(prolinol)phenol complex.
ChemInform Abstract: An Easy Access to Carbazolones and 2,3‐Disubstituted Indoles.
Authors: Janreddy Donala , Kavala Veerababurao , Bosco J. W. John , Kuo Chun‐Wei , Yao Ching‐Fa 
Published: August 2011

AbstractDifferent fused pyrrole derivatives are efficiently synthesized by the present new cheap method.
ChemInform Abstract: Straightforward Access to (Imidazol‐2‐yl)acetates by Reaction of 2‐Unsubstituted Imidazole 3‐Oxides with Dimethyl Acetylenedicarboxylate.
Authors: Mloston Grzegorz , Jasinski Marcin , Heimgartner Heinz 
Published: August 2011

AbstractThe formation of the desired imidazoles is rationalized by a formal 1,3‐dipolar cycloaddition reaction followed by an oxaloyl cleavage of oxobutanoate intermediates (III).
ChemInform Abstract: Pd‐Catalyzed ortho‐Arylation of N‐Aryloxazolidinones with Simple Arenes Using Sodium Persulfate.
Authors: Yeung Charles S. , Dong Vy M. 
Published: August 2011

AbstractThis oxidative cross‐coupling approach for the direct functionalization of N‐aryloxazolidinones is conducted by employing unactivated arenes as the coupling partners and sodium persulfate as an environmentally benign and easy to handle stoichiometric oxidant.
ChemInform Abstract: Synthesis of Hydroxylated 3,4‐Dihydropyridine‐2‐ones from Intramolecular Nucleophilic Addition Reaction of Oxirane‐Containing Tertiary Enamides.
Authors: Yang Luo , Tong Shuo , Wang De‐Xian , Huang Zhi‐Tang , Zhu Jieping , Wang Mei‐Xiang 
Published: August 2011

AbstractOxirane‐containing tertiary enamides (V) undergo cyclization via intramolecular nucleophilic addition to the epoxide moiety.
ChemInform Abstract: A New Three‐Component Reaction: Green Synthesis of Novel Isoindolo[2,1‐a]quinazoline Derivatives as Potent Inhibitors of TNF‐α.
Authors: Pal Manojit , et al. et al. 
Published: August 2011

AbstractSome of the novel isoindolinoquinazolines, e.g. (III) and (Vd), show significant inhibition of TNF‐α.
ChemInform Abstract: New Ferrocenic Pyrrolo[1,2‐a]quinoxaline Derivatives: Synthesis and in vitro Antimalarial Activity. Part 2.
Authors: Guillon Jean , et al. et al. 
Published: August 2011

AbstractA series of title compounds of type (I) and (II) is prepared and evaluated for their in vitro activity against Plasmodium falciparum strains.
ChemInform Abstract: Four New Sesquiterpenoids from the Fruits of Alpinia oxyphylla.
Authors: Lv Xiao‐Qing , Luo Jian‐Guang , Wang Xiao‐Bing , Wang Jun‐Song , Luo Jun , Kong Ling‐Yi 
Published: August 2011

AbstractTwo new norsesquiterpenoids, oxyphyllenotriol A (I) and oxyphyllone G (II), and two new sesquiterpenoids, oxyphyllols D (III) and E (IV), are isolated from title plant fruits.
ChemInform Abstract: Structure and Cytotoxicity of Phidianidines A (Ia) and B (Ib): First Finding of 1,2,4‐Oxadiazole System in a Marine Natural Product.
Authors: Carbone Marianna , Li Yan , Irace Carlo , Mollo Ernesto , Castelluccio Francesco , Di Pascale Antonio , Cimino Guido , Santamaria Rita , Guo Yue‐Wei , Gavagnin Margherita 
Published: August 2011

AbstractThe structures of the title compounds are determined by spectroscopic means.
ChemInform Abstract: New Bicyclotridecane C15 Nonterpenoid Bromoallenes from Laurencia marilzae.
Authors: Gutierrez‐Cepeda Adrian , Fernandez Jose J. , Norte Manuel , Souto Maria L. 
Published: August 2011

AbstractThe structures of the new title allenes, marilzabicycloallenes A—D, are determined by spectroscopic means.
ChemInform Abstract: Synthesis of the Reported Structure of Crassiflorone, a Naturally Occurring Quinone Isolated from the African Ebony Diospyros crassiflora, and Regioisomeric Pentacyclic Furocoumarin Naphthoquinones.
Authors: Padwal Jalindar , Lewis William , Moody Christopher J. 
Published: August 2011

AbstractThe synthesis of the proposed structure of crassiflorone (Ia) as well as that of three regioisomers (Ib), (II) is presented.
Toward efficient protocol design through protocol profiling and performance assessment: using formal verification in a different context
Authors: Georgoulas Stylianos , Moessner Klaus 
Published: August 2011

SUMMARYThe most common use of formal verification methods so far has been in identifying whether livelock and/or deadlock situations can occur during protocol execution, process, or system operation. In this work, we aim to show that an additional equally important and useful application of formal verification methods can be in protocol design in terms of performance‐related metrics. This can be achieved by using the methods in a rather different context compared with their traditional use, that is, not only as model checking tools to assess the correctness of a protocol in terms of lack of livelock and deadlock situations but rather as tools capable of building profiles of protocol operations, assessing their performance, and identifying operational patterns and possible bottleneck operations. This process can provide protocol designers with an insight about the protocols’ behavior and guide them toward further optimizations. It can also assist network operators and service providers to assess the protocols’ relative performance and select the most suitable protocol for specific deployment scenarios. We illustrate these principles by showing how formal verification tools can be applied in this protocol profiling and performance assessment context using some existing protocol implementations in mobile and wireless environments as case studies. Copyright © 2011 John Wiley & Sons, Ltd.
Building the posterior lateral line system in zebrafish
Authors: Chitnis Ajay B. , Dalle Nogare Damian , Matsuda Miho 
Published: August 2011

AbstractThe posterior lateral line (pLL) in zebrafish has emerged as an excellent system to study how a sensory organ system develops. Here we review recent studies that illustrate how interactions between multiple signaling pathways coordinate cell fate, morphogenesis, and collective migration of cells in the posterior lateral line primordium. These studies also illustrate how the pLL system is contributing much more broadly to our understanding of mechanisms operating during the growth, regeneration, and self‐organization of other organ systems during development and disease. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 234–255, 2012
A numerical method for the simulation of an aggregation‐driven population balance system
Authors: Hackbusch Wolfgang , John Volker , Khachatryan Aram , Suciu Carina 
Published: August 2011

SUMMARYA population balance system that models the synthesis of urea is studied in this paper. The equations for the flow field, the mass and the energy balances are given in a three‐dimensional domain, while the equation for the particle size distribution is given in a four‐dimensional domain. This problem is convection‐dominated and aggregation‐driven. Both features require the application of appropriate numerical methods. This paper presents a numerical approach for simulating the population balance system, which is based on finite element schemes, a finite difference method and a modern method to evaluate convolutIon integrals that appear in the aggregation term. Two experiments are considered and the numerical results are compared with experimental data. Unknown parameters in the aggregation kernel have to be calibrated. For appropriately chosen parameters, good agreements are achieved of the experimental data and the numerical results computed with the proposed method. A detailed study of the computational results reveals the influence of different parts of the aggregation kernel. Copyright © 2011 John Wiley & Sons, Ltd.
Surgical management of paget's disease
Authors: Kaplan Frederick S. 
Published: August 2011

Abstract
Orthopedic complications of Paget's disease occur commonly and arise as a result of chronically accelerated bone remodeling in focal regions of the skeleton. Complications include pathologic fractures with delayed union, progressive skeletal deformity, chronic bone pain and pagetic arthritis. The new bisphosphonates have transformed the treatment of Paget's disease in the past decade but have not yet been studied in depth for their ability to prevent orthopaedic complications. Although few patients with Paget's disease ever require surgical intervention, successful operative management of orthopaedic complications has dramatically improved the quality of life for many sufferers. Selected modalities with promising results include total hip replacement for end-stage pagetic arthritis of the hip, total knee replacement for end-stage pagetic arthritis of the knee, proximal tibial osteotomy for painful malalignment of the knees, internal fixation for pathological fractures, and decompressive laminectomy for spinal stenosis. Complications of surgery on pagetic bone include hemorrhage, infection, pathologic fracture, delayed union, nonunion, and aseptic loosening of hardware. Medical, surgical, and rehabilitative modalities provide a wide array of options in managing orthopaedic complications of Paget's disease and are useful in improving quality of life for sufferers of the condition. Prospective studies are needed to assess the ability of antipagetic medications to prevent severe long-term complications such as deformity, arthritis, and malignancy. Localization of susceptibility genes for Paget's disease may accelerate identification of targets for gene therapy and disease prevention.
Chemical composition, angiotensin‐converting enzyme‐inhibitory activity and antioxidant activities of few‐flower wild rice (Zizania latifolia Turcz.)
Authors: Qian Bingjun , Luo Yali , Deng Yun , Cao Linkui , Yang Hongshun , Shen Yongpei , Ping Jian 
Published: August 2011

AbstractBACKGROUND: The chemical compositions of the stem and leaf sheath of few‐flower wild rice were analysed. In addition, their extracts were evaluated for diphenylpicrylhydrazyl (DPPH) free radical‐scavenging activity, ferric‐reducing antioxidant power and angiotensin‐converting enzyme (ACE)‐inhibitory activity, since these are important properties of sources of nutraceuticals or functional foods.RESULTS: The stems contained more ascorbic acid (0.06 g kg−1 fresh weight), protein (28.18 g kg−1 dry weight (DW)), reducing sugars (308.54 g kg−1 DW), water‐soluble pectin (20.63 g kg−1 DW), Na2CO3‐soluble pectin (44.14 g kg−1 DW), K (8 g kg−1 dry matter (DM), S (6 g kg−1 DM) and P (5 g kg−1 DM) but less starch, total dietary fibre, Si, Na and Ca than the leaf sheaths. The DPPH free radical‐scavenging IC50 values of the stem and leaf sheath extracts were 19.28 and 21.22 mg mL−1 respectively. In addition, the ACE‐inhibitory IC50 value of the stem extracts was 38.54 mg mL−1.CONCLUSION: Both the stem and leaf sheath extracts exhibited good antioxidant properties, while good ACE‐inhibitory activity was detected only in the phosphate buffer solution extracts of the stem. Few‐flower wild rice could be processed into formula feeds for fish, poultry, etc. or functional foods for persons with high blood pressure. Copyright © 2011 Society of Chemical Industry
NMR spectra and structures of oridonin derivatives complexes with β‐cyclodextrin
Authors: Liu Wei , Zhao Bing , Li Yin‐Chao , Liu Hong‐Min 
Published: August 2011

AbstractComplexations between three oridonin derivatives and β‐cyclodextrin (βCD) were studied by nuclear magnetic resonance (NMR) method. Job's plots for complexes were depicted by 1H NMR spectra chemical shifts, which proved the 1:1 stoichiometry inclusion complex formation between each derivative and βCD. Two‐dimensional rotating frame overhauser effect spectroscopy (2D ROESY) support the above conclusion and also proved that ring A of each oridonin derivative deeply enters into hydrophobic cavity from the wider rim and the other parts are outside the cavity. Apparent formation constants (Ka) of complexes between three oridonin derivatives and two CDs are calculated according to Scott's equation. Copyright © 2011 John Wiley & Sons, Ltd.
Lead ion removal characteristics of poly(lactic acid)/hydroxyapatite composite foams prepared by supercritical CO2 process
Authors: Jeon Byung Jin , Jeong Young Gyu , Min Byung Gil , Lyoo Won Seok , Lee Sang Cheol 
Published: August 2011

AbstractWe have prepared a series of poly(lactic acid)/hydroxyapatite (PLA/HAp) composite foams by a supercritical CO2 foaming process and investigated the lead ion (Pb2+) removal performances of the foam samples in batch aqueous solutions (foam sample of 5 g, aqueous solution of 500 ml, initial Pb2+ ion concentration of 275 mg/l, pH values of 2.0–6.0) at 25°C. It is characterized that the porosity of the foams decreases from 96.3% to 50.3% as the HAp content increases from 0 to 40 wt%, although all the foam samples exhibit well‐developed open porous structures. The maximum capacity of Pb2+ ions removed by the composite foams increases from 81.2 to 140.5 mg/g with increasing the HAp content from 10 to 40 wt%, due to the increased adsorption sites of HAp for Pb2+ ions. However, the removal kinetic analysis based on the pseudo‐second order model demonstrates that the Pb2+ ion removal rate is slightly faster for the composite foams with higher porosity (i.e., lower HAp content). The maximum Pb2+ ion removal capacity of a given composite foam increases from 20.2 to 140.5 mg/g with increasing the initial pH value from 2.0 to 5.0 but it decreases slightly to 111.7 mg/g at the initial pH value of 6.0. POLYM. COMPOS., 2011. © 2011 Society of Plastics Engineers
Polysomnography in preterm infants and children with chronic lung disease
Authors: McGrath‐Morrow Sharon A. , Ryan Timothy , McGinley Brian M. , Okelo Sande O. , Sterni Laura M. , Collaco J. Michael 
Published: August 2011

AbstractObjectiveTo determine the utility of overnight polysomnography (PSG) in assessing pulmonary reserve in stable preterm children with chronic lung disease (CLD).Study designA retrospective review and descriptive study of overnight PSGs and clinic visits of preterm infants/children less than 3 years of age who were diagnosed with bronchopulmonary dysplasia at discharge from the hospital and enrolled in the Johns Hopkins CLD patient registry between 2008 and 2010.ResultsSixty‐two clinically stable patients underwent at least one overnight polysomnogram for clinical indications. The majority of patients were referred for oxygen titration (71%). PSGs from first studies revealed a mean respiratory disturbance index (RDI) of 8.2 ± 10.1 events/hr and a mean O2 saturation (SaO2) nadir of 86.2 ± 5.7%. In patients who underwent more than one PSG (n = 23), a significant decrease in RDI (P < 0.001) was found between the first study (mean age: 8.0 ± 3.3 months) and second study (mean age: 13.4 ± 5.2 months). Outpatient clinical measures of mean room air SaO2 and respiratory rate were not predictive of PSG measures of RDI and SaO2 nadir.ConclusionMean RDI was higher in stable preterm infants/children with CLD compared to previously published controls. RDI decreased with age in stable preterm infants/children with CLD suggesting improved pulmonary reserve with age. Outpatient clinical measures (respiratory rate and room air SaO2) did not correlate with RDI and SaO2 nadir indicating that overnight PSG is more sensitive in assessing pulmonary reserve than outpatient clinical measures. Pediatr Pulmonol. 2012; 47:172–179. © 2011 Wiley Periodicals, Inc.
Centimeter‐Scale High‐Resolution Metrology of Entire CVD‐Grown Graphene Sheets
Authors: Kyle Jennifer Reiber , Guvenc Ali , Wang Wei , Ghazinejad Maziar , Lin Jian , Guo Shirui , Ozkan Cengiz S. , Ozkan Mihrimah 
Published: August 2011

AbstractA high‐throughput metrology method for measuring the thickness and uniformity of entire large‐area chemical vapor deposition‐grown graphene sheets on arbitrary substrates is demonstrated. This method utilizes the quenching of fluorescence by graphene via resonant energy transfer to increase the visibility of graphene on a glass substrate. Fluorescence quenching is visualized by spin‐coating a solution of polymer mixed with fluorescent dye onto the graphene then viewing the sample under a fluorescence microscope. A large‐area fluorescence montage image of the dyed graphene sample is collected and processed to identify the graphene and indicate the graphene layer thickness throughout the entire graphene sample. Using this metrology method, the effect of different transfer techniques on the quality of the graphene sheet is studied. It is shown that small‐area characterization is insufficient to truly evaluate the effect of the transfer technique on the graphene sample. The results indicate that introducing a drop of acetone or liquid poly(methyl methacrylate) (PMMA) on top of the transfer PMMA layer before soaking the graphene sample in acetone improves the quality of the graphene dramatically over immediately soaking the graphene in acetone. This work introduces a new method for graphene quantification that can quickly and easily identify graphene layers in a large area on arbitrary substrates. This metrology technique is well suited for many industrial applications due to its repeatability and flexibility.