bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined multilevelanti‐agingstrategies and practical applications of dermocosmetics in aesthetic procedures
Authors: Park Kui Young , López Gehrke Ingrid 
Published: June 2024

AbstractManagement of the signs of facial aging and other cosmetic skin problems have greatly evolved in the past years. People are also seeking to improve their well‐being and global skin appearance, and when they consider using cosmetic procedures, they expect natural and long‐lasting aesthetic results. Combined dermocosmetic approaches that address the signs of facial aging at all levels are increasingly being used by dermatologists to meet patient expectations while ensuring their safety. Minimally invasive and reversible procedures that can be performed in only one session are popular approaches for skin restructuring and volumizing as they are flexible, rapid and less burdensome for patients. These interventions can achieve even better outcomes when they are combined with cosmeceuticals as pre‐ or post‐procedural adjuvants to prepare the skin, accelerate recovery and sustain results. The use of topical dermocosmetics is also recommended as part of the daily skin care routine to improve skin quality and help maintain skin barrier function. This review thus outlines the most commonly used combined multilevel anti‐aging strategies, which start by addressing the deepest skin layers and then the more superficial signs of skin aging. Examples of multi‐active cosmeceuticals and skin delivery enhancing systems are also presented, together with examples of the use of dermocosmetics as supportive care for aesthetic procedures, to provide insights into current applications of dermocosmetic products.
Meta‐analysis to predict the effects of probiotics on meat quality of broiler
Authors: Yibar Artun , Uzabaci Ender 
Published: June 2024

AbstractThe demand for chicken meat has surged globally due to its status as a primary protein source in human diets. However, ensuring high‐quality meat products has become an increasingly important subject to consumers. In this study, 21 articles from PubMed and Web of Science databases published between 2005 and 2023 were examined to assess the influence of probiotic supplementation on broiler meat quality. The meta‐analysis revealed significant findings across various meat quality parameters. Specifically, probiotics were found to significantly affect meat colour parameters, including redness, yellowness, and lightness, in both breast and thigh meat samples. Moreover, significant differences were observed in parameters such as water‐holding capacity (p < 0.001), cook loss (p = 0.047), and shear force (p = 0.025) between control and probiotic groups. However, it's essential to note the considerable heterogeneity among the studies, emphasising the need for a cautious interpretation of the results. Despite this variability, the study underscores the potential of probiotics to positively influence broiler meat quality, highlighting avenues for further research and standardisation in poultry production practices. These findings also contribute to a better understanding of probiotics’ role in improving meat quality and meeting consumer preferences for nutritious and high‐quality poultry products.
Detection times of clodronic acid in horses with orthopedic disease
Authors: Seguí Pedrosa Beatriz , Dujardin Chris , Moses Ben , Thompson Caryn , Sarasola Patxi , Gattacceca Florence , Loup Benoit , Garcia Patrice , Popot Marie‐Agnès , Bailly‐Chouriberry Ludovic 
Published: June 2024

AbstractClodronic acid is designated as a controlled medication for competition horses by the International Federation for Equestrian Sports and, according to the International Federation of Horseracing Authorities, clodronic acid is not to be administered to racehorses younger than 3.5 years or within 30 days prior to a race. In this study, 35 horses involved in competition were treated with a single dose of 1.53 mg clodronic acid/kg bodyweight intramuscularly. Plasma samples were obtained before treatment and 10, 20, 30, and 40 days post‐administration. Clodronic acid concentrations were measured using a validated method, and the data were fitted using a nonlinear mixed effects model. The estimated depletion half‐life of clodronic acid was 10.6 days (inter‐individual variability: 17.9%). Age, body weight, sex, disease severity, dose, training days, training, and competition did not significantly impact the depletion half‐life. The percentage of horses predicted via simulation to have clodronic acid concentrations below the assay's limit of quantification of 1.0 ng/mL was 93.9% at day 30 and 99.4% at Day 40. This study provides rationale to the equestrian federations and horse racing authorities to reliably establish a detection time for clodronic acid, assisting equine veterinarians in recommending a competition withdrawal time for the horses under their care.
Impact of Suaahara, an at‐scale multisectoral nutrition programme, on health workers' maternal and child health, and nutrition knowledge and skills in Nepal
Authors: Thapa Deependra K. , Frongillo Edward A. , Suresh Shalini , Adhikari Ramesh P. , Pun Bhim , Shakya Karuna L. , Mandal Raj , Kole Subir K. , Cunningham Kenda 
Published: June 2024

AbstractSuaahara, an at‐scale multisectoral nutrition programme in Nepal, aimed to advance knowledge and skills of frontline health workers to improve the quality of nutrition and health services at health facility and community levels. This study assessed the impact of Suaahara interventions on knowledge and skills of health facility workers and Female Community Health Volunteers (FCHVs). The study used a quasi‐experimental design in which four Suaahara intervention districts were compared with pair‐matched comparison districts. One health facility worker and three FCHVs from each survey cluster were included. Baseline survey consisted of 93 health facility workers (2015) and 118 FCHVs (2012), and endline survey (2022) consisted of 40 health facility workers and 120 FCHVs. Difference‐in‐differences regression models employing intent‐to‐treat analysis, accounting for clustering at the district level, assessed the impact of intervention. The intervention, relative to comparison, had no effect on health facility workers’ knowledge. There was a positive effect, however, on FCHVs’ knowledge in intervention relative to comparison areas on exclusive breastfeeding, timing of introduction of complementary feeding, sick child feeding and growth monitoring and promotion (GMP) for children under 2 years. Health facility workers and FCHVs in intervention versus comparison districts had higher endline scores for skills related to measuring the weight of children and pregnant women, measuring the height/length of children, conducting GMP for children under 2 years and identifying malnourished children. Suaahara interventions improved the capacity of health workers, particularly nutrition‐related knowledge among FCHVs and GMP‐related skills of both health facility workers and FCHVs.
Multicenter Candida auris outbreak caused by azole‐susceptible clade IV in Pernambuco, Brazil
Authors: Spruijtenburg Bram , Nobrega de Almeida Júnior João , Ribeiro Felipe de Camargo , Kemmerich Karoline Kristina , Baeta Karla , Meijer Eelco F. J. , de Groot Theun , Meis Jacques F. , Colombo Arnaldo Lopes ,   Brazilian Candida auris collaborative network
Published: June 2024

AbstractBackgroundCandida auris is an emerging multidrug‐resistant yeast, frequently causing outbreaks in health care facilities. The pathogen persistently colonises human skin and inanimate surfaces such as catheters, aiding to its spread. Moreover, colonisation is a risk factor to develop invasive infection.ObjectivesWe investigated 61 C. auris strains isolated from non‐sterile human body sites (n = 53) and the hospital environment (n = 8), originating from four different centres in a single Brazilian state.Materials and MethodsAntifungal susceptibility testing (AFST) against common antifungals was performed, and resistance‐associated genes were evaluated. Genetic relatedness was investigated with short tandem repeat (STR) genotyping and validated with whole‐genome sequencing (WGS) single nucleotide polymorphism (SNP) analysis.ResultsAntifungal susceptibility testing demonstrated that all isolates were susceptible to azoles, echinocandins and amphotericin B. No mutations were detected in ERG11 and FKS1 genes. With STR typing, isolates were allocated to clade IV and appeared closely related. This was confirmed by WGS SNP analysis of 6 isolates, which demonstrated a maximal difference of only 41 SNPs between these strains. Furthermore, the Brazilian isolates formed a distinct autochthonous branch within clade IV, excluding recent introductions from outside the country. A molecular clock analysis of clade IV isolates from various countries suggests that early in the previous century there was a unique event causing environmental spread of a C. auris ancestor throughout the Latin‐American continent, followed by human introduction during the last decades.ConclusionWe report the emergence of C. auris patient colonisation in multiple centres by fluconazole‐susceptible clade IV close‐related strains in Pernambuco State, Brazil.
A synchronized, large‐scale field experiment using Arabidopsis thaliana reveals the significance of the UV‐B photoreceptor UVR8 under natural conditions
Authors: Neugart Susanne , Steininger Viktoria , Fernandes Catarina , Martínez‐Abaigar Javier , Núñez‐Olivera Encarnación , Schreiner Monika , Strid Åke , Viczián András , Albert Andreas , Badenes‐Pérez Francisco R. , Castagna Antonella , Dáder Beatriz , Fereres Alberto , Gaberscik Alenka , Gulyás Ágnes , Gwynn‐Jones Dylan , Nagy Ferenc , Jones Alan , Julkunen‐Tiitto Riitta , Konstantinova Nataliia , Lakkala Kaisa , Llorens Laura , Martínez‐Lüscher Johann , Nybakken Line , Olsen Jorunn , Pascual Inmaculada , Ranieri Annamaria , Regier Nicole , Robson Matthew , Rosenqvist Eva , Santin Marco , Turunen Minna , Vandenbussche Filip , Verdaguer Dolors , Winkler Barbro , Witzel Katja , Grifoni Daniele , Zipoli Gaetano , Hideg Éva , Jansen Marcel A. K. , Hauser Marie‐Theres 
Published: June 2024

AbstractThis study determines the functional role of the plant ultraviolet‐B radiation (UV‐B) photoreceptor, UV RESISTANCE LOCUS 8 (UVR8) under natural conditions using a large‐scale ‘synchronized‐genetic‐perturbation‐field‐experiment’. Laboratory experiments have demonstrated a role for UVR8 in UV‐B responses but do not reflect the complexity of outdoor conditions where ‘genotype × environment’ interactions can mask laboratory‐observed responses. Arabidopsis thaliana knockout mutant, uvr8‐7, and the corresponding Wassilewskija wild type, were sown outdoors on the same date at 21 locations across Europe, ranging from 39°N to 67°N latitude. Growth and climatic data were monitored until bolting. At the onset of bolting, rosette size, dry weight, and phenolics and glucosinolates were quantified. The uvr8‐7 mutant developed a larger rosette and contained less kaempferol glycosides, quercetin glycosides and hydroxycinnamic acid derivatives than the wild type across all locations, demonstrating a role for UVR8 under field conditions. UV effects on rosette size and kaempferol glycoside content were UVR8 dependent, but independent of latitude. In contrast, differences between wild type and uvr8‐7 in total quercetin glycosides, and the quercetin‐to‐kaempferol ratio decreased with increasing latitude, that is, a more variable UV response. Thus, the large‐scale synchronized approach applied demonstrates a location‐dependent functional role of UVR8 under natural conditions.
The physiological and biochemical role of silicon in enhancing the resistance of maize to root‐lesion nematode
Authors: Qi Xiuxiu , Xue Xia , Su Guoquan , Han Yanlai , Wang Yi , Li Yu , Jiang Ying 
Published: June 2024

AbstractSilicon (Si) plays an important role in enhancing the tolerance of plants to biotic and abiotic stress in soil ecosystems. Root‐lesion nematodes (Pratylenchus scribneri; RLNs) cause root damage and diseases that result in quality deterioration and economic loss. This study investigated the effects of Si application on maize plants and its interaction with RLN infection. We set up different treatments to evaluate the role of silicon application in maize root growth and RLN resistance. This study conducted analysis by combining measurements of the metabolism and root activity of maize under different conditions. The results suggested that Si application (0.5 g/kg) significantly promoted fresh shoot weight, plant height, SPAD value (chlorophyll content), and root activity of maize, regardless of RLN inoculation. The highest SPAD value was observed in the Si treatment, which was significantly higher than in the control (CK) and RLN (N) treatments. Analysis of enzyme activity revealed that nematode inoculation reduced catalase (CAT) activity and increased malondialdehyde (MDA) concentration, while Si application increased CAT activity and decreased MDA concentration. In the SiN treatment, there was increased CAT activity at 0, 12, 48, 72 and 96 h compared with the N treatment. In parallel, nematode inoculation increased phenylalanine ammonia‐lyase (PAL), and polyphenol oxidase (PPO) activities, while SiN treatment further enhanced their activities. These findings indicate that Si application enhances maize resistance to nematode infection and improves plant growth and antioxidant defence mechanisms.
Correlation between cigarette smoking and alcohol consumption and Rosacea: A two‐sample Mendelian randomization study
Authors: Wang Juan , Zhang Lingli 
Published: June 2024

AbstractBackgroundControversy persists regarding the causal relationship between Cigarette smoking, alcohol consumption, and Rosacea. This paper employs the Mendelian randomization (MR) method to elucidate the correlation between Cigarette smoking, alcohol consumption, and Rosacea. The aim is to contribute valuable insights to aid in the prevention and early treatment of Rosacea.MethodSummary datasets for cigarette smoking parameters (Cigarettes smoked per day, Smoking status: Previous, smoking status: Current) and alcohol consumption (Alcoholic drinks per week) were selected alongside data for Rosacea from genome‐wide association studies (GWAS). The Two‐sample MR method was employed to analyze the correlation between cigarette smoking, alcohol consumption, and Rosacea. Various MR analysis methods, including inverse variance weighting (IVW), MR‐Egger, Simple Mode, Weighted Mode, and Weighted Median, were chosen. IVW served as the primary analysis method.ResultsThe results indicate a significant negative association between Cigarettes smoked per day and Rosacea. Moreover, a significant positive correlation was observed between Smoking status: Previous and Rosacea. However, no significant associations were found between Smoking status: Current, Alcoholic drinks per week, and Rosacea.ConclusionThis study provides further clarity on the association between cigarette smoking, drinking, and Rosacea through a two‐sample MR analysis. Notably, the number of cigarettes smoked per day appears to be associated with a reduced incidence of Rosacea, while cigarette smoking cessation may increase the risk. Surprisingly, alcohol consumption does not emerge as a significant risk factor for Rosacea. These findings contribute to a nuanced understanding of the complex relationship between lifestyle factors and the occurrence of Rosacea, offering potential insights for preventive measures and early intervention.
Enhancement of Exfoliating Effects through the Novel Cosmetic Ingredient Mandelic acid_Carnitine Ion‐Pairing Complex
Authors: Jeon Hyungjoon , Park Nojin , Won Jong Gu , Shin Yong Won , Choi Jiwon , Park Sang‐Wook , Son Nam Seo 
Published: June 2024

AbstractPurposeThis study aimed to develop a novel exfoliating material with high efficacy and low irritation by synthesizing the Mandelic acid_Carnitine ion pairing complex (M_C complex) and evaluating its exfoliating properties. Additionally, the study assessed the skin improvement effects of the M_C complex through clinical evaluations.MethodsThe M_C complex was synthesized in a 1:1 molar ratio of Mandelic acid and Carnitine. Structural characterization was performed using dynamic light scattering and Fourier‐transform infrared spectroscopy. Exfoliating efficacy was evaluated on porcine skin, and clinical assessments were conducted on human subjects to measure various skin improvement parameters.ResultsThe formation of the M_C complex was confirmed through particle size analysis, zeta‐potential measurements, and FT‐IR spectroscopy. The M_C complex demonstrated superior exfoliating efficacy compared to Mandelic acid alone, especially at pH 4.5. Clinical evaluations showed significant improvements in blackheads, whiteheads, pore volume, depth, density, count, and affected area, as well as skin texture. No adverse reactions were observed.ConclusionThe M_C complex exhibits high exfoliating efficacy and minimal irritation, making it a promising cosmetic ingredient for improving skin health. These findings support its potential as a low‐irritation exfoliating material under mildly acidic conditions, contributing to overall skin health enhancement.
Diffuse reflectance spectroscopy for assessing soil quality indicators in cocoa production system validated using multi‐year data
Authors: Majeed Israr , Singh Kanika , Fidelis Chris , Yinil David , Minasny Budiman , Das Bhabani S. , Field Damien J. 
Published: June 2024

AbstractDiffuse reflectance spectroscopy is emerging as a reliable soil testing approach. However, few studies reported on the applicability of DRS for estimating the overall soil quality index (SQI) in smallholder farms. Specifically, the DRS approach has not been evaluated in cocoa production systems with multi‐year soil data. We evaluated the DRS approach in typical cocoa production systems from Papua New Guinea (PNG) by collecting soil samples before and after implementing soil test‐based nutrient recommendations. Specifically, 379 soil samples were collected in 2017 from cocoa farms in East New Britain, New Ireland, and Bouganville provinces of PNG. A second soil testing campaign was undertaken in 2019 to analyse 432 soil samples from the same farms to test the consistency of the DRS approach for SQI assessment. In all these samples, 15 soil parameters were measured using the conventional wet chemistry approach. Reflectance spectra in each sample were also measured over the visible to near‐infrared (wavelength: 350–2500 nm). A minimum dataset approach was followed to estimate SQIs from laboratory‐measured soil properties. With available N, clay content, available P, and available Zn adjudged as significant soil quality parameters for the cocoa plantations of PNG, estimated mean SQI values ranged from 0.30 in the cocoa farm from Bouganville province (BOKA‐PAN) in 2017 to 0.46 for the New Ireland province (LAU‐PAN) soil samples collected during 2019. Overall, SQI values increased from about 13%–21% following the nutrient applications. Based on the validation of two commonly‐used chemometric models (PLSRFS: partial‐least‐squares regression with feature selection, SVR: support vector regression), the SQI values were estimated with the coefficient of determination (R2) values as high as .94. Our results showed that a DRS model calibrated in soil samples collected in a specific year can be used for estimating SQI values in soil samples collected in different years. These results suggest that the principal component analysis (PCA) based SQI may be estimated from the DRS data with good accuracy and SQI values may potentially capture the management effects in smallholder farms.
Environmental Impact, Mechanical Properties, and Productivity: Considerations on Filler Wire and Scanning Strategy in Laser Welding
Authors: Liverani Erica , Angeloni Caterina , Ascari Alessandro , Fortunato Alessandro 
Published: June 2024

Abstract
Sustainability, as well as high-quality outcomes, pose significant challenges within the context of current manufacturing cycles, in alignment with European strategies aimed at decarbonization. This framework encourages a systematic evaluation of manufacturing processes in terms of their performance and carbon footprint. One sector where this is particularly relevant is the production of batteries for electric mobility, thanks to its exponential growth. Out of all the processes involved, laser welding stands out as being a critical step since it offers potential energy savings through optimization. With the dual goals of achieving mechanical strength and environmental sustainability, this study investigates alternative solutions for laser welding of aluminum sheets. Different laser welding configurations are tested to evaluate the effect of process setups on weld quality and carbon emissions across different productivity scenarios. The key findings can be summarized as follows: (1) the selection of welding setup significantly influences both quality and sustainability requirements; (2) the optimal conditions for meeting strength requirements may diverge from those aimed at minimizing environmental impact; (3) the choice of the final solution is influenced by the specific industrial scenario. The study specifically demonstrated that aluminum alloys can be welded with higher quality (porosity below 1% and equivalent ultimate strength up to 204 MPa) when filler wire is introduced alongside an active wobbling scanning strategy. Conversely, filler wire can be omitted in scenarios prioritizing high-productivity and low-carbon emissions, such as when employing a linear scanning strategy, resulting in a reduction of equivalent carbon emissions by up to 140%.
Three-Dimensional-Digital Image Correlation Methodology for Kinematic Measurements of Non-Penetrating Blunt Impacts
Authors: LeSueur Joseph , Koser Jared , Yoganandan Narayan , Pintar Frank A. 
Published: June 2024

Abstract
Blunt force trauma remains a serious threat to many populations and is commonly seen in motor vehicle crashes, sports, and military environments. Effective design of helmets and protective armor should consider biomechanical tolerances of organs in which they intend to protect and require accurate measurements of deformation as a primary injury metric during impact. To overcome challenges found in velocity and displacement measurements during blunt impact using an integrated accelerometer and two-dimensional (2D) high-speed video, three-dimensional (3D) digital image correlation (DIC) measurements were taken and compared to the accepted techniques. A semispherical impactor was launched at impact velocities from 14 to 20 m/s into synthetic ballistic gelatin to simulate blunt impacts observed in behind armor blunt trauma (BABT), falls, and sports impacts. Repeated measures Analysis of Variance resulted in no significant differences in maximum displacement (p = 0.10), time of maximum displacement (p = 0.21), impact velocity (p = 0.13), and rebound velocity (p = 0.21) between methods. The 3D-DIC measurements demonstrated equal or improved percent difference and low root-mean-square deviation compared to the accepted measurement techniques. Therefore, 3D-DIC may be utilized in BABT and other blunt impact applications for accurate 3D kinematic measurements, especially when an accelerometer or 2D lateral camera analysis is impractical or susceptible to error.