bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Nanotechnology Associated With Natural Products as a Strategy for the Control of Plutella Xylostella (Linnaeus, 1758) (Lepidoptera, Plutellidae)
Authors: de Almeida Alini , Schmitz Edinéia Paula Sartori , Peres Gisele Louro , Llinzmeier Adelita Maria 
Published: May 2024

Abstract

The diamondback moth is a cosmopolitan microlepidoptera considered one of the world’s most important pests of Brassicaceae. In Brazil, losses caused by this species reach one billion dollars per year. Despite the existence of natural control methods such as plant-based products and entomopathogenic fungi and bacteria, the synthetic pesticides are still the main products used to its control, which are associated to numerous harms to health and the environment. In this scenario, nanotechnology combined with natural products are promising for the formulation of new natural insecticides so, the main aim of this study was to test a new a natural nanotechnological insecticide based on Lithothamnion calcareum (Corallinaceae), a red alga associated with guar-guar, a natural biopolymer, to combat or control individuals of Plutella xylostella (Linnaeus 1758) the so-called seaweed-biopolymer solution (SbS). This solution and its respective controls at different concentrations were subjected to insecticidal viability tests by contact and ingestion on second instar larvae of P. xylostella. In the contact test, after 13 hours of exposure, 100% of the individuals were dead. In the ingestion test there was a decrease in pupal biomass and the number of eggs deposited. Therefore, the solutions at concentrations of 2.5% and 1.25% proved to be efficient in controlling P. xylostella, indicating that the seaweed-biopolymer solution can be employed as a new strategy for control and minimization of the damage caused by this pest.
Safety and feasibility of High-Frequency Oscillatory Ventilation for the control respiratory movement in patients with Thoracoabdominal Tumors receiving Heavy Ion precision Therapy
Authors: Wang Yi , Zhao Wenxue , Tang Yutian , Wang Fang , Ye Yancheng , Zhang Yanshan , Peng Xiaojing , Yang Wenyuan , Sun Yanqing , Niu Limei , Wang Yanzhi 
Published: May 2024

Abstract

Introduction;
The aim of this study was to investigate the safety and feasibility of the high-frequency oscillatory ventilation (HFOV) technique for the management of respiratory motion in patients with thoracoabdominal malignancies undergoing heavy ion precision therapy.
Methods;
A retrospective analysis of clinical data from 30 patients with thoracoabdominal malignant tumors treated with heavy ion therapy under the control of high-frequency oscillatory ventilation at one Cancer Hospital was conducted from January 2023 to March 2024. Patient's general conditions, respiratory motion, and other clinical parameters were analyzed and compared before, during, and after the treatment to determine the value of utilizing HFOV for managing thoracoabdominal malignancies in patients undergoing heavy ion therapy.
Results;
There was no significant difference in heart rate, blood pressure, blood oxygen saturation, or tcpCO2 before, during, or after treatment (P > 0.05). In addition, HFOV improved the patient's tcpO2 values (P < 0.001). However, the lung respiratory motion under HFOV was 1.33 ± 0.39 mm, which was significantly lower than that in the spontaneous respiration status (19.31 ± 4.22mm, P < 0.001), and "missed targeting" was not observed during radiotherapy. Throughout the treatment process, one case complicated with hypertension and hypercapnia was observed, and two patients experienced nausea and vomiting after extubation. Radiation pneumonia occurred in 1 of 30 patients, and the mean hospital stay was 22.13 ± 10.94 days. The results showed that the objective response rate was 93.1%, the complete response rate was 41.37%, and the partial response rate was 51.72%. No death occurred during the follow-up period.
Conclusion;
HFOV is safety for thoracoabdominal tumor patients to receive high doses of precise heavy ion therapy, thereby enhancing treatment efficacy. Further randomized controlled trial is needed to confirm this discovery.
Prophylactic mastectomies in patients with breast cancer and known germline pathogenetic variants: an Austrian registry
Authors: Leser Carmen , Deutschmann Christine , Dorffner Georg , Gschwantler-Kaulich Daphne , Abayev Sara , Stübler Madeleine , Reitsamer Roland , Singer Christian 
Published: May 2024

Abstract

Objectives
Risk-reducing surgeries are common in patients with breast cancer gene (BRCA) mutations. Certain patients develop breast cancer before they opt for these surgeries. We aimed to examine the frequency of risk-reducing mastectomies and salpingo-oophorectomy among Austrian patients with breast cancer and BRCA mutations.
Methods
In 2014, we established an Austrian registry with patients with known germline pathogenetic variants. From onset until 2018, 111 patients were recruited from four breast cancer centers. Data on the type of mastectomy, reconstructions, and complications were collected.
Results
Of all patients, 13.5% had bilateral breast cancer. Among patients with unilateral breast cancer, the majority (86.8%) opted for prophylactic mastectomy on the contralateral side. Those who underwent modified radical mastectomy were more likely to choose prophylactic surgery (p = 0.001). A total of 19.4% of patients experienced cancer relapse postoperatively. Immediate reconstructions were recorded in 71.3% of the patients. In addition, patients undergoing immediate reconstruction were more likely to undergo a prophylactic operation on the contralateral side than those with delayed reconstruction (p = 0.001). A mesh was used in 47.8% of all reconstructions. The subpectoral implant was present in 75.6% of patients and the pre-pectoral in 13.3%. A mesh was inserted in all patients with pre-pectoral implants.
Conclusion
The results indicate that the willingness for risk-reducing surgeries is high and the option for immediate reconstruction is preferably selected by the patients with breast cancer.
The Visual Midline and its Associations in Healthy Adults
Authors: Ding Ran , Stalin Amritha , Leat Susan J. , Labreche Tammy 
Published: May 2024

Abstract

A visual midline (VM) shift may be experienced by some individuals post-stroke, but its associations with other variables are unclear. This study explored the relationships between the VM and other vision and non-vision variables in healthy adults. Normative data were calculated, and repeatability was assessed for each test. 93 participants without a history of visual or neurological impairment were recruited. Horizontal and vertical VM were measured using a VM gauge. During visit 1, the line bisection test (LBT) for spatial neglect, ocular dominance (OD), subjective straight-ahead (SSA), and visual open loop testing were also conducted. During visit 2, all assessments were repeated in Hong Kong while participants in Canada repeated VM measurements. Results showed no significant correlation between VM gauge measurements and other vision variables for either visit (P > 0.05). Age was significantly correlated with the absolute vertical VM during the first visit (Spearman’s rho = 0.47, P < 0.001), and with the absolute horizontal VM during the second visit (Spearman’s rho = 0.30, P = 0.004). LBT and OD tests had good repeatability (Limits of Agreement for Repeatability were 4 mm for LBT and 7 cm for OD). The visual open loop and SSA had poorer repeatability. This study revealed that VM is not associated with other vision variables in healthy adults. Therefore, it may be processed by independent neurological processing. This information is important for understanding the origins of VM shift, and normative data will aid clinicians in diagnosis.
CT-based measurement and analysis of distal humerus morphology in healthy adults from Northern China
Authors: Yang Shuai , Wang Fengkun , Zhang Boyu , Ye Zhipeng , Guan Haitao , Zhang Xiaojuan , Zhang Yingze 
Published: May 2024

Abstract

Background This study utilized computed tomography and three-dimensional reconstruction techniques to investigate the morphological characteristics of the distal humerus in healthy adults from northern China, and compared whether there were differences in populations distal humeral data from different geographical areas.
Methods 80 standard CT images of the distal humerus were selected from the hospital's image archiving system and analysed using Mimics software. The differences in geometric and morphological parameters of the distal humerus between sexes and sides were compared, and whether there was a correlation between each parameter was investigated. The geometric and morphological parameters of the distal humerus were compared between Western and Chinese populations based on current and previous pooled results.
Results 31 morphological parameters were measured and analysed in this study. On the whole, in the morphological parameters section, the mean and standard deviation of capitellum depth, capitellum width and capitellum height were 10.83 ± 1.18 mm, 17.60 ± 2.06 mm and 21.10 ± 2.03 mm, respectively. The mean of distal humerus width and humeral metaphyseal width were 44.38 ± 4.07 mm and 58.95 ± 4.86 mm. The trochlear groove high and trochlear widthwere 16.63 ± 1.96 mm and 26.78 ± 2.96 mm. The humeral axis angle, medial crest coronal tangential angle, lateral crest coronal tangential angle, medial crest sagittal tangential angle, lateral crest sagittal tangential angle was 86.22 ± 3.27°, 43.05 ± 7.53°, 16.03 ± 7.32°, 7.52 ± 11.00° and 37.31 ± 9.10° , respectively. This study shows that all morphological parameters of the distal humerus are significantly higher in males than in females, with the exception of the trochlear offset distance. The gender differences in the angle parameters in this study were insignificant. The capitellum width (r = -0.300, P < 0.01), anterior lateral trochlear depth (r =-0.227, P< 0.05), medial crest coronal tangential angle (r = 0.307, P<0.01), olecranon fossa volume (r = -0.408, P <0.01), olecranon fossa surface area (r = -0.345, P< 0.01) and coronoid fossa surface area (r = -0.279, P<0.05) were significantly correlated with the age of the subjects. The capitellum height (P < 0.001*), lateral trochlear high (P < 0.001*), trochlear groove high (P < 0.001*), trochlear depth (P < 0.001*) and medial trochlear high (P < 0.001*) were smaller in the Chinese population compared with the Western people, while capitellum width (P < 0.001 *) and capitellum depth (P < 0.001 *) were more prominent.
Conclusion This research aims to serve as a reference for diagnosing and classifying distal humeral diseases, designing orthopedic implants, improving surgical quality and guiding patient recovery.
The precision of technical aspects in the minimally invasive Broström-Gould procedure：A Cadaveric Anatomical Study
Authors: Zhang Guolei , Li Wenqing , Yao Haibo , Tan Rongzhi , Li Chuyan 
Published: May 2024

Abstract

BackgroundA comprehensive understanding of the anatomy of the anterolateral ankle joint and its interrelationships is essential for advancing the development of minimally invasive Brostrom-Gould procedure, thereby enhancing surgical efficacy and minimizing postoperative complications.MethodsTen fresh human ankle specimens were dissected to observe the shape and trajectory of the lateral bundle of the inferior extensor retinaculum（IER） and its relationship with the deep fascia. To observe the relationship between the ankle capsule and the anterior talofibular ligament（ATFL）. The center of the insertion point of ATFL at the lateral malleolus was used as the reference point.The vertical distance from the reference point to the fibula tip, the horizontal distance from the reference point to the lateral branch of the superficial peroneal nerve, the shortest distance from the reference point to IER，and the narrowest width of the IER were measured. The tension of ATFL was observed and measured. To describe the minimally invasive Broström-Gould procedure according to the anatomical characteristics of the anterolateral ankle joint.ResultsAmong the 10 cases, 8 cases (80%) had double bundles of ATFL, 2 cases (20%) had single bundle of ATFL, and no outer superior oblique bundle was observed in IER. The vertical distance from the reference point to the fibula tip was 1.2±0.3(range 1.1-1.3)mm. The shortest distance from the reference point to the level of the superficial peroneal branch was 28.2±4.3(range 24.5-32.4)mm. The shortestdistance from the reference point to IER was 12.5±0.6(range 12.1-12.9)mm, and the width of IER at this point was 7.2±0.3(range 7.0-7.6)mm. The Angle between this point and the ATFL insertion and the fibula longitudinal axis was about 60°±2.8°(range 58.1°-62.1°)mm. The space between the anterolateral deep fascia of the ankle joint and the ankle capsule is very small, and only a few fat granules are separated between them. The ATFL is largely fused to the ankle capsule.ConclusionsThe results showed that in the minimally invasive Broström-Gould technique for lateral ankle stabilization, the Broström procedure actually sutured the insertion of the ATFL together with the ankle capsule to the anterior edge of the lateral malleolus. In the Gould procedure, the deep fascia was mostly reinforced with the ankle capsule. The maximum tension was obtained when the Gould suture needle direction was at an Angle of 60° to the longitudinal axis of the fibula.
Identification of disulfidptosis-related lncRNA signature using RNA-Sequencing and Bioinformatics Analysis in Head and Neck Squamous Cell Carcinoma
Authors: Chen Qi , Shi Xiao , Bao Yuanyuan , Chen Yue 
Published: May 2024

Abstract

As a novel form of regulated cell death, disulfidptosis generating a favorable opportunity in better understanding of tumor pathogenesis and therapeutic strategies. Long non-coding RNAs (lncRNAs) regulate the biology functions of tumor cells with combination of variable targets. However, the prognostic value of disulfidptosis-related lncRNAs (DRlncRNAs) in head and neck squamous cell carcinoma (HNSC) remains largely unknown. Hence, we aimed to delve into the molecular characteristics of HNSC, focusing on disulfidptosis-related long non-coding RNAs (DRLs), and explore potential therapeutic strategies. We conducted lncRNA-mRNA RNA-Seq analyses on HNSC cell lines and utilized The Cancer Genome Atlas (TCGA) database, comprising RNA sequencing, clinical data, and gene mutation information from 522 HNSC tumors and 44 normal tissues. Bioinformatics analyses were employed to identify DRLs associated with disulfidptosis and assess their prognostic significance. Additionally, a risk model based on three selected DRLs was constructed to investigate its correlation with patient outcomes. Tumor mutation burden and chemotherapeutic responses were also explored in relation to the risk model. Our analysis pinpointed three DRLs (LINC02434, AC245041.2, and LINC02762) significantly correlated with HNSC prognosis. qRT-PCR results validated the consistency of LINC02434 and AC245041.2. The risk model, based on these DRLs, effectively stratified patients into high- and low-risk groups, revealing distinct survival patterns. Furthermore, the risk model demonstrated independent prognostic value in HNSC. Examination of the tumor microenvironment highlighted differences between high- and low-risk groups, suggesting potential implications for immunotherapeutic approaches. Specific chemotherapeutic agents with varying sensitivities across risk groups and molecular subtypes were identified. The identified three DRLs signature emerges as a novel biomarker with predictive value for HNSC prognosis. This study provides insights into potential therapeutic avenues and contributes to our understanding of the molecular landscape of HNSC.
Mn doping improves the photocatalytic performance of CdS photocatalysts
Authors: Qi Shuyan , Li Haiyang , Zhang Kaiyao , hu Xu , Wu Shanqiang , Guan Ling 
Published: May 2024

Abstract

In recent years, CdS photocatalytic materials are known for their relatively narrow bandgap and high light-absorbing ability, which is favoured by a wide range of academics in the field of photocatalysis. However pure CdS photogenerated carriers are susceptible to complexation and photocorrosion, so the photocatalytic effect is not ideal. In order to improve the photocatalytic performance of CdS, to study the mechanisms of their modification, this thesis employs transition metal (Mn)-doped CdS to enhance its photocatalytic performance and improve photocorrosion. MnxCd1-xS in cubic sphalerite phase was prepared by hydrothermal method, the photocatalytic decolourisation of 50 mL of 10 mg/L MB by Mn0.2Cd0.8S at 240 min in the photocatalytic experiment was 90 %, with a reaction rate constant of 0.00982 min-1, 3.86 times that of the cubic sphalerite phase CdS. The reaction rate constant was 0.01102 min-1, which is 4.42 times greater than the hexagonal fibrous zinc ore phase CdS. The doping of Mn both led to an increase in the photocatalytic stability of CdS, the main active groups in the photocatalytic degradation of MB by MnxCd1-xS were all O2-·.
Disrespect and abuse during childbirth and associated factors among women: a cross-sectional study
Authors: dolatabadi Zari , farahani Leila amiri , zargar Zahra , haghani Shima , mousavi Seyedeh saeedeh 
Published: May 2024

Abstract

Background:Respectful maternity care is a fundamental right for all women. However, reports of disrespect and abuse are prevalent in various childbirth settings. This study aimed to assess the disrespect and abuse experienced by women during childbirth and associated factors in Comprehensive health centers of Tehran, Iran.Methods:This study employed a cross-sectional design to investigate the prevalance of disrespect and abuse among women who had recently delivered vaginally. The sample comprised 300 mothers who gave birth within the last five days in Tehran, Iran. Data collection occurred between April and September 2021 using a two-stage cluster sampling method and systematic random sampling technique. A demographic and midwifery questionnaire, alongside the Disrespect and Abuse Questionnaire, were used to collect data. Statistical analysis was performed using SPSS version 26. Descriptive statistics (frequencies, percentages, means, and standard deviations) were employed alongside inferential statistics including chi-square tests and logistic regression.Results:This study revealed a high prevalence of disrespect and abuse, with 68.3% of mothers experiencing at least one form from the seven identified dimensions. When examining the factors contributing to the increase in disrespect and abuse, it was observed that Turkish women had a 67% lower prevalence of disrespect and abuse compared to fars women (OR: 0.339). Mothers with unwanted pregnancies were 2.3 times more likely to experience disrespect and abuse during labor (OR: 2.317). the prevalence of disrespect and abuse was 88% lower in women who received care from a physician compared to those who were attended by a midwife (OR: 0.129). Experience of disrespect and abuse increased 7.1 times when the mother was unaware of who was responsible for her care (OR: 7.190). Mothers without a companion during labor experienced 74% less disrespect and abuse compared to women who had a companion (OR: 0.263). Finally, women who did not undergo instrumental delivery had a 92% reduction in the incidence of abuse (OR: 0.088).Conclusion:This study revealed a high prevalence of disrespect and abuse during childbirth. All mothers should experience consistent and utmost respect throughout the childbirth. Execution of respectful care advancement must be the business of all healthcare providers.
Multi-omics analysis reveals molecular mechanism of flavonol biosynthesis during the formation of petal color in Camellia nitidissima
Authors: Feng Yi , Li Jiyuan , Yin Hengfu , Shen Jian , Liu Weixin 
Published: May 2024

Abstract

Background
Camellia nitidissima is a rare and prized species of camellia with golden-yellow flowers, and has high ornamental, medicinal and economic value. Previous studies showed that the content of flavonol accumulated greatly in petals during the formation of golden petal. However, the molecular mechanism of golden flower formation in C. nitidissima remains largely unknown.
Results
In this study, we performed an integrative analysis of transcriptome, proteome, and metabolome of petals at five developmental stages to construct the regulatory network during golden flower formation in C. nitidissima. Metabolome analysis showed that 323 flavonoids were detected, and epically two flavonols, the quercetin and kaempferol glycosides, were highly accumulated in the golden petals. And transcriptome and proteome sequencing suggested that the expression of flavonol biosynthesis genes or proteins was increased in golden petal stage, whereas expression of anthocyanin and proanthocyanidin genes or proteins were decreased. Further investigation revealed that several putative transcription factors, MYBs and bHLHs, were identified as potentially involved in flavonoid biosynthesis. Expression analysis showed that Flavonol Synthase gene 2 (CnFLS2) was specifically overexpressed in petals, and the expression of CnFLS2 of petals at five developmental stages was positively correlated with flavonol content. Overexpression of CnFLS2 in petals increased flavonol content. Furthermore, analysis showed that the jasmonate (JA) pathways was positively correlated with flavonol biosynthesis, and methyl jasmonate (MeJA) treatment induced the expression of CnFLS2 and the accumulation of flavonol.
Conclusions
This work describes that JA-CnFLS2 module regulates flavonol biosynthesis during golden petal formation in C. nitidissima.
Identification and validation of a novel defined stress granule-related gene signature for predicting the prognosis of ovarian cancer via bioinformatics analysis
Authors: Chen Xiaoqi , Han Qianqian , Pu Yongqiang 
Published: May 2024

Abstract

Background
Ovarian cancer (OC) is a malignant gynecological cancer with an extremely poor prognosis. Stress granules (SGs), nonmembrane organelles, are responses to stress stimuli. However, the correlations between SG-related genes and prognosis in OC remain unclear.
Methods
In this study, RNA-seq data and clinical information from GSE18520 and GSE14407 in the Gene Expression Omnibus (GEO) and ovarian plasmacytoma adenocarcinoma in The Cancer Genome Atlas (TCGA) were downloaded. SG-related genes were obtained from GeneCards, MSigDB, and the literature. First, thirteen SG-related genes were identified in the prognostic model by using least absolute shrinkage and selection operator (LASSO) Cox regression. The prognostic value of each SG-related gene for survival and its relationship with clinical characteristics were evaluated. Next, we performed functional enrichment analysis of SG-related genes. Then, the protein-protein interactions (PPIs) of SG-related genes were visualized by Cytoscape with STRING.
Results
According to the median risk score from the LASSO Cox regression, a thirteen-gene signature was created and classified all OC patients in the TCGA cohort and GEO into high- and low-risk groups. A total of five SG-related genes were differentially expressed between the high-risk and low-risk groups of OC in GEO. A total of thirteen SG-related genes were related to several important oncogenic pathways (TNF-α signaling, PI3K-AKT-mTOR signaling, and WNT-βcatenin signaling) and several cellular components (cytoplasmic stress granule, cytoplasmic ribonucleoprotein granule, and ribonucleoprotein granule). The PPI network identified eleven hub genes that obtained the highest interaction between ELAVL1 and other genes.
Conclusion
Taken together, SG-related genes (DNAJA1, ELAVL1, FBL, GRB7, MOV10, PABPC3, PCBP2, PFN1, RFC4, SYNCRIP, USP10, ZFP36, ZFP36L1) can be used to predict the prognosis of OC.