bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wind direction and complex sediment transport response across a beach–dune system
Authors: Bauer Bernard O. , Davidson‐Arnott Robin G. D. , Walker Ian J. , Hesp Patrick A. , Ollerhead Jeff 
Published: July 2012

ABSTRACTEvidence from a field study on wind flow and sediment transport across a beach–dune system under onshore and offshore conditions (including oblique approach angles) indicates that sediment transport response on the back‐beach and stoss slope of the foredune can be exceedingly complex. The upper‐air flow – measured by a sonic anemometer at the top of a 3·5 m tower located on the dune crest – is similar to regional wind records obtained from a nearby meteorological station, but quite different from the near‐surface flow field measured locally across the beach–dune profile by sonic anemometers positioned 20 cm above the sand surface. Flow–form interaction at macro and micro scales leads to strong modulation of the near‐surface wind vectors, including wind speed reductions (due to surface roughness drag and adverse pressure effects induced by the dune) and wind speed increases (due to flow compression toward the top of the dune) as well as pronounced topographic steering during oblique wind approach angles.A conceptual model is proposed, building on the ideas of Sweet and Kocurek (Sedimentology 37: 1023–1038, 1990), Walker and Nickling (Earth Surface Processes and Landforms 28: 111–1124, 2002), and Lynch et al. (Earth Surface Processes and Landforms 33: 991–1005, 2008, Geomorphology 105: 139–146, 2010), which shows how near‐surface wind vectors are altered for four regional wind conditions: (a) onshore, detached; (b) onshore‐oblique, attached and deflected; (c) offshore, detached; and (d) offshore‐oblique, attached and deflected. High‐frequency measurements of sediment transport intensity during these different events demonstrate that predictions of sediment flux using standard equations driven by regional wind statistics would by unreliable and misleading. It is recommended that field studies routinely implement experimental designs that treat the near‐surface wind field as comprising true vector quantities (with speed and direction) in order that a more robust linkage between the regional (upper air) wind field and the sediment transport response across the beach–dune profile be established. Copyright © 2012 John Wiley & Sons, Ltd.
The effects of a novel‐reinforced bone substitute and Colloss®E on bone defect healing in sheep
Authors: Ding Ming , Røjskjær Jesper , Cheng Liming , Theilgaard Naseem , Overgaard Søren 
Published: July 2012

AbstractHydroxyappatite‐β‐tricalciumphosphate (HA/β‐TCP) was reinforced with poly(D,L)‐lactic acid (PDLLA) to overcome its weak mechanical properties. Two substitutes with porosities of 77% and 81% HA/β‐TCP reinforced with 12 wt % PDLLA were tested in compression. The effects of allograft, substitute (HA/β‐TCP‐PDLLA), Colloss®E, and combination of substitute with Colloss®E on bone formation in vivo were evaluated. Cylindrical critical size defects were created at distal femoral condyles bilaterally in sheep. Titanium implant with concentric gap filling with one of the four materials was inserted. After 9 weeks, the sheep were sacrificed. Implants with surrounding bone were harvested and sectioned into two parts: one for microcomputed tomography scanning and push‐out test, and one for histomorphometry. The 77% HA/β‐TCP reinforced with PDLLA had similar mechanical properties to human cancellous bone and was significantly stronger than the HA/β‐TCP without PDLLA. Microarchitecture of gap mass was significantly changed after implantation for all groups. Allograft had stronger shear mechanical properties than the other three groups, whereas there were no significant differences between the other three groups. Significant new bone formation could be seen in vivo in all four groups and there were no significant differences between them. The PDLLA‐reinforced substitute seems to be good alternative substitute material for bone healing in sheep. Further investigations should be performed to validate this novel substitute material. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
Risk of Overestimation of Kidney Function Using GFR‐Estimating Equations in Patients with Low Inulin Clearance
Authors: Nakata Junichiro , Ohsawa Isao , Onda Kisara , Tanimoto Mitsuo , Kusaba Gaku , Takeda Yukihiko , Kobayashi Noriyoshi , Asanuma Katsuhiko , Tanaka Yuichi , Sato Michiko , Inami Yuko , Suzuki Hitoshi , Suzuki Hiyori , Masuda Atsumi , Nonaka Kanae , Sasaki Yu , Hisada Atsuko , Hamada Chieko , Horikoshi Satoshi , Tomino Yasuhiko 
Published: July 2012

BackgroundAccurate estimation of the glomerular filtration rate (GFR) is very important in clinical practice. Although renal inulin clearance (Cin) is the gold standard for measuring GFR, the procedure for Cin measurement is complicated. Use of GFR‐estimating equations has been increasing recently due to their simplicity. The objectives of the present study are to analyze the correlation between Cin and other GFR‐estimating parameters and to investigate their clinical usefulness and limitation.MethodsSeventy‐two Japanese patients were enrolled in this study. Cin was measured by the continuous infusion method. Serum creatinine (s‐Cr), cystatin C, uric acid (UA), and hemoglobin (Hb) were measured. The Japanese formula of estimated GFR (eGFR) was as follows: eGFR (ml/min/1.73m2) = 194 × s‐Cr−1.094 × Age−0.287 × 0.739 (if female). The endogenous creatinine clearance test was also performed.ResultsLevels of Cin were highly correlated with those of endogenous creatinine clearance (Ccr) (R2 = 0.7585) and eGFR (R2 = 0.5659). However, patients with lower Cin showed unexpectedly elevated levels of endogenous Ccr and eGFR. Moreover, the levels of eGFR tended to be unexpectedly increased in patients with low body surface area.ConclusionAlthough GFR‐estimating equations are useful for estimating GFR accurately, they pose a risk of overestimation of kidney function in patients with decreased GFRor a poor physique. J. Clin. Lab. Anal. 26:248‐253, 2012. © 2012 Wiley Periodicals, Inc.
Extended depth from focus reconstruction using NIH ImageJ plugins: Quality and resolution of elevation maps
Authors: De Oliveira Hein Luis Rogerio , De Oliveira José Alberto , De Campos Kamila Amato , De Oliveira Caltabiano Pietro Carelli Reis 
Published: July 2012

AbstractIn this work, NIH ImageJ plugins for extended depth‐from‐focus reconstructions (EDFR) based on spatial domain operations were compared and tested for usage optimization. Also, some preprocessing solutions for light microscopy image stacks were evaluated, suggesting a general routine for the ImageJ user to get reliable elevation maps from grayscale image stacks. Two reflected light microscope image stacks were used to test the EDFR plugins: one bright‐field image stack for the fracture of carbon‐epoxy composite and its darkfield corresponding stack at same (x,y,z) spatial coordinates. Image quality analysis consisted of the comparison of signal‐to‐noise ratio and resolution parameters with the consistence of elevation maps, based on roughness and fractal measurements. Darkfield illumination contributed to enhance the homogeneity of images in stack and resulting height maps, reducing the influence of digital image processing choices on the dispersion of topographic measurements. The subtract background filter, as a preprocessing tool, contributed to produce sharper focused images. In general, the increasing of kernel size for EDFR spatial domain‐based solutions will produce smooth height maps. Finally, this work has the main objective to establish suitable guidelines to generate elevation maps by light microscopy. Microsc. Res. Tech. 2012. © 2012 Wiley Periodicals, Inc.
SOCIAL EXCLUSION, SOCIAL COHESION: DEFINING NARRATIVES FOR DEVELOPMENT IN LATIN AMERICA
Authors: de Roldán Karem Sánchez 
Published: July 2012

AbstractThis paper analyzesThe Social Panorama of Latin America, an overview of the social scene in Latin America provided by Economic Commission for Latin America and the Caribbean, as a development narrative. In it, there are two interwoven and competing stories, the economic and the social. The gradual appearance and disappearance of key ideas for development, such as social exclusion/inclusion and social cohesion, in the context of concurrent trends in common social indicators, suggest the subordination of the social story to the economic one. Social dimensions of development deserve renewed attention for complete overviews of the social panorama of Latin America. Copyright © 2012 John Wiley & Sons, Ltd.
BEYOND SUBJECTIVE WELL‐BEING: A CRITICAL REVIEW OF THE STIGLITZ REPORT APPROACH TO SUBJECTIVE PERSPECTIVES ON QUALITY OF LIFE
Authors: White Sarah C. , Gaines Stanley O. , Jha Shreya 
Published: July 2012

AbstractThis paper welcomes the Stiglitz Report's placing of wellbeing at the centre of policy discussions of measuring economic performance and social progress. However, the paper critiques the identification of subjective perspectives on quality of life solely with subjective well‐being. The paper locates subjective well‐being within psychological wellbeing, happiness and quality of life studies more broadly. It argues for attention to concepts, not just techniques, and more engagement with social and political perspectives. It draws on empirical research in Zambia and India to show that context matters and qualitative research is needed to complement quantitative measures of wellbeing. Copyright © 2012 John Wiley & Sons, Ltd.
Molecular cloning, structural analysis and mass spectrometric identification of native dioscorins of various yam species
Authors: Tsai Wei‐Yi , Jheng Yi‐Jyun , Chen Kuo‐Hsuan , Lin Kuo‐Wei , Ho Yen‐Pen , Yang Ching‐Chi , Lin Kuo‐Chih 
Published: July 2012

AbstractBACKGROUND: Dioscorins are the major storage proteins of yam tubers. However, the molecular nature of their heterogeneity in tubers has not been fully elucidated. In this study the authors isolated the dioscorin gene families of Dioscorea japonica and Dioscorea pseudojaponica, performed matrix‐assisted laser desorption/ionisation time‐of‐flight mass spectrometry (MALDI‐TOF‐MS) and elucidated which dioscorin isoforms are the major constituents in tubers.RESULTS: The dioscorin gene families of D. japonica (Dj‐dioA1‐Dj‐dioA4, Dj‐dioB1 and Dj‐dioB2) and D. pseudojaponica (Dp‐dioA1‐Dp‐dioA5 and Dp‐dioB1) were cloned from cDNA libraries of yam tubers. The dioscorins isolated from Dioscorea alata (Da‐dioscorins), D. japonica (Dj‐dioscorins) and D. pseudojaponica (Dp‐dioscorins) were mainly monomers, with a few dimers. The monomers contained one intramolecular disulfide bond (Cys28‐Cys187) and belonged to Class A dioscorins with two cysteine residues. The dimers consisted of Class B dioscorins with one intermolecular disulfide bond (Cys40‐Cys40). Results of MALDI‐TOF‐MS revealed that the Da‐dioscorins were mainly encoded by Da‐dioA2, Da‐dioA3 and Da‐dioA4. The majority of the Dj‐dioscorins were encoded by Dj‐dioA1, Dj‐dioA2, Dj‐dioA3 and Dj‐dioB2. The Dp‐dioscorins mainly comprised proteins encoded by Dp‐dioA1, Dp‐dioA3, Dp‐dioA4, Dp‐dioB1 and Dp‐dioB2.CONCLUSION: Determination of the constituents of dioscorin isoforms in yam tubers provides a basis for future studies of their physiological and biomedical functions. © 2012 Society of Chemical Industry
Functional and antioxidative properties of protein hydrolysates from Cape hake by‐products prepared by three different methodologies
Authors: Pires Carla , Clemente Teresa , Batista Irineu 
Published: July 2012

AbstractBACKGROUND: The production of fish protein hydrolysates (FPH) is a convenient technology for upgrading fish by‐products. The aim of this work was to study three different methods of FPH preparation from Cape hake by‐products to improve yield and quality. Functional and antioxidative properties of all FPHs were determined.RESULTS: The protein content of hake FPH was in the range 807–860 g kg−1 and the degree of hydrolysis was between 19% and 22%. The maximum yield (71.9%) was achieved by methodology B but the hydrolysate was darker. The peptide profile of all FPHs was very similar. FPH prepared by methodology C had significantly higher emulsifying activity index and hydrolysate prepared by methodology B had the highest foaming capacity. The solubility of FPH was in the range 71–76% and increased the water‐holding capacity of minced fish by about 9%. The fractionation of FPH obtained by methodologies A and B allowed concentrating peptides with higher radical scavenging activity and reducing power.CONCLUSION: The properties of the FPH prepared indicated that they can be used in food systems as natural additives, particularly to improve their water‐holding capacity. © 2012 Society of Chemical Industry
Hyperthermic isolated limb perfusion for extremity soft tissue sarcomas: Systematic review of clinical efficacy and quality assessment of reported trials
Authors: Trabulsi N.H. , Patakfalvi L. , Nassif M.O. , Turcotte R.E. , Nichols A. , Meguerditchian A.N. 
Published: July 2012

AbstractBackground and ObjectivesExtremity soft tissue sarcomas (STS) are managed with radiotherapy and limb‐sparing surgery however aggressive or recurrent cases require amputation. Hyperthermic isolated limb perfusion (HILP) has been proposed as an alternative. Our aim was to systematically review phase II HILP trials, assess tumor response, limb salvage (LS), and quality of scientific publications on this technique.MethodsWe conducted a literature search of electronic databases (MEDLINE, EMBASE, Scopus, Cochrane Library) and clinical trial registries for phase II HILP trials on non‐resectable extremity STS. Outcomes of interest were complete response (CR), partial response (PR), and LS rates. Quality of published trials was assessed using a quality checklist.ResultsOf 518 patients across 12 studies, 408 had some response (CR or PR), and 428 had the limb spared. Median CR, PR, and LS rates were 31%, 53.5%, and 82.5%, respectively. Median Wieberdink loco‐regional toxicity rates were 3.8%, 45.5%, 17%, 1%, and 0% for levels 1–5, respectively. No trial fulfilled either all ideal or essential quality criteria. Seven trials did not include statistical methodology.ConclusionHILP seems effective in treating advanced extremity STS. However, poor publication quality hinders results validity. Technical and methodological standardization, well‐designed, multi‐institutional trials are warranted. J. Surg. Oncol. 2012; 106: 921–928. © 2012 Wiley Periodicals, Inc.
Primary aldosteronism
Authors: Carey Robert M. 
Published: July 2012

AbstractPrimary aldosteronism is the most common form of secondary hypertension. Case detection is based on an abnormal plasma aldosterone:plasma renin activity ratio and the diagnosis must be confirmed with an aldosterone suppression test. Subtype differentiation should be performed using adrenal venous sampling. Approximately 50% of patients with primary aldosteronism will have a unilateral aldosterone‐producing adenoma; laparoscopic adrenalectomy results in cure of hypertension in 60% and improvement in blood pressure control in the remainder. J. Surg. Oncol. 2012; 106:575–579. © 2012 Wiley Periodicals, Inc.
Using Nanosilica to Fine‐Tune Morphology and Properties of Polyamide 6/Poly(propylene) Blends
Authors: Laoutid Fouad , François Damien , Paint Yoann , Bonnaud Leila , Dubois Philippe 
Published: July 2012

AbstractThe effect of hydrophilic and hydrophobic nanosilica on the morphological, mechanical and thermal properties of polyamide 6 (PA) and poly(propylene) (PP) blends is investigated by extrusion compounding. Depending on the difference between the polymer/nanoparticle interfacial tensions, different morphologies are obtained as highlighted by TEM and SEM. Hydrophobic nanosilica migrates mainly at the PA/PP interface, which leads to a clear refinement of PP droplet size. The macroscopic properties of the hybrid blends are discussed and interpreted in relation with the blend morphology and melt‐mixing procedure. The control over coalescence allows a morphology refinement of the blends and improves mechanical properties. magnified image
Highly efficient unsymmetrical doherty power amplifier with DPD for LTE application
Authors: Xia Jing , Zhu Xiaowei 
Published: July 2012

AbstractThis article presents a highly efficient Doherty power amplifier (DPA) with 4.4% relative signal bandwidth for long‐term evolution (LTE) application at frequency band of 450–470 MHz.To maintain high efficiency at large back‐off power (BOP), the DPA is unsymmetrical and the carrier and peaking amplifiers are implemented to show unequal saturation power. Experimental results using continuous wave signal indicate a power‐added efficiency (PAE) of 64.3% at saturation power of 49.9 dBm and a PAE of 62% at about 6‐dB BOP. For 20 MHz LTE signal, the adjacent channel leakage ratio is −30 dBc and can be improved to −49 dBc by using the digital predistortion technique at an average output power of 41.5 dBm with a PAE of 51%. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2352–2356, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27043
Simple efficient resonant coupling wireless power transfer system operating at varying distances between antennas
Authors: Park Jongmin , Lee Sungho , Tak Youndo , Nam Sangwook 
Published: July 2012

AbstractWe found the optimal conditions for an efficient wireless power transfer system (WPTS).In addition, we found that a class‐D power amplifier (PA) has an advantage as a source when the input resistance changes with the position of the receiving antenna. Finally, the proposed WPTS was verified through the experimental results. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27062
Development of UWB bandpass filter with reconfigurable notches to suppress IEEE 802.11 a/b services
Authors: Thirumalaivasan K. , Nakkeeran R. 
Published: July 2012

AbstractThis letter presents a developed ultrawideband bandpass filter with reconfigurable notches to suppress the interference from wireless local area network services.The filter with discrete tuning provision is built in microstrip line that consists of ring resonator, interdigital coupling, and embedded open stubs (EOS). The reconfiguration is realized using a pair of fast switching diodes that are placed between EOS and strip line. The filter provides an excellent wide bandwidth (from 1.8 to 7.8 GHz) and rejection performance of −41 dB at 2.6 GHz and −24 dB at 5.3 GHz. The total size of the developed filter with the above features is 39.2 × 6 mm2. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2423–2426, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27065
A novel butterfly‐shaped multilayer backward microstrip hybrid coupler for ultrawideband applications
Authors: Ahmed Osama M. H. , Sebak Abdel‐Razik , Denidni Tayeb A. 
Published: July 2012

AbstractIn this letter, the numerical analysis and design of aperture‐coupled backward microstrip hybrid coupler for ultrawideband (UWB) multilayer microwave circuits are introduced. The proposed coupler is composed of two microstrip patches located on two stacked substrate layers. This coupler uses a broadside coupling via a rectangular‐shaped slot in the common ground plane (mid‐layer). To achieve broadband characteristics for UWB operation, butterfly‐shaped patches are used. The numerically simulated results using two simulation programs with two different numerical techniques show that the proposed coupler have good insertion losses (both through S21
and coupled S31) variation (less than ±2 dB) and high return loss S11 (greater than 14 dB) with acceptable isolation S41 (about 14 dB) over most of the 3.1–10.6‐GHz frequency band. A 3dB/90°‐backward hybrid coupler prototype is fabricated and then tested experimentally using Agilent E8364B PNA Network Analyzer. Experimental results agree well with the simulated ones. © 2012 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:2231–2237, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27092
Spontaneous and pronase‐induced HER2 truncation increases the trastuzumab binding capacity of breast cancer tissues and cell lines
Authors: Recupero Daniele , Daniele Lorenzo , Marchiò Caterina , Molinaro Luca , Castellano Isabella , Cassoni Paola , Righi Alberto , Montemurro Filippo , Sismondi Piero , Biglia Nicoletta , Viale Giuseppe , Risio Mauro , Sapino Anna 
Published: July 2012

AbstractA subgroup of HER2‐overexpressing breast tumours co‐expresses p95$^{{\rm{HER2}}}$, a truncated HER2 receptor that retains a functional HER2 kinase domain but lacks the extracellular domain, thus impairing trastuzumab binding. We evaluated p95$^{{\rm{HER2}}}$ expression in 99 frozen breast carcinoma samples by western blot analysis. The HER2‐positive cell line BT474 treated with pervanadate or pronase was used as a positive control for p95$^{{\rm{HER2}}}$ expression. Immunohistochemistry was performed on parallel formalin‐fixed, paraffin‐embedded sections of the same case series using antibodies directed against either the intra‐ or extra‐cellular binding domain of HER2. In particular, biotinylated trastuzumab (BiotHER) was used to evaluate the binding capacity of the humanized antibody. To avoid a subjective evaluation of the score values and the percentage of immunostained cells, the slides were scanned and automatically analysed. The number of cases with HER2 overexpression (score 3+) and HER2 gene amplification was higher in the p185$^{{\rm{HER2}}}$‐positive/p95$^{{\rm{HER2}}}$‐positive samples than in the p185$^{{\rm{HER2}}}$‐positive/p95$^{{\rm{HER2}}}$‐negative group. Automated analysis confirmed a significantly higher percentage of 3+ scored cells in p95$^{{\rm{HER2}}}$‐positive cases. Conversely, the percentage of 2+ scored cells was higher in p95$^{{\rm{HER2}}}$‐negative cases. The status of the HER2 extracellular domain was then studied using flow cytometry on BT474 cells after pronase enzymatic digestion using trastuzumab and pertuzumab, while the presence of HER2‐HER3 dimers was studied using a proximity‐ligation assay. In vitro experiments showed that short‐term pronase digestion of BT474 cells produced two HER2 fragments (of 95 and 150 kDa, detectable in tissue specimens as well), increased the binding affinity of trastuzumab, reduced the rate of HER2–HER3 dimers, and did not interfere with pertuzumab‐binding capacity. In conclusion, the presence of p95$^{{\rm{HER2}}}$ as detected by western blot analysis does not compromise the immunohistochemical detection of HER2. Our data suggest that a reduction of the receptor steric hindrance as induced by enzymatic shedding may facilitate the binding capacity of trastuzumab. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Increased circulating apoptotic lymphocytes in children with Down syndrome
Authors: Gemen Eugenie F.A. , Verstegen Ruud H.J. , Leuvenink Jacqueline , de Vries Esther 
Published: July 2012

AbstractDown syndrome (DS) resembles immunodeficiency with increased infections, auto‐immune diseases, and hematological malignancies. Until now, immunological studies in DS mainly focused on T‐lymphocytes. We recently described a profound B‐lymphocytopenia in children with DS. This could be caused by increased apoptosis. Therefore, we determined expression of flowcytometric markers for apoptosis [Annexin‐V (AV) and propidium iodide (PI)] on peripheral lymphocytes in 72 children with DS and 32 age‐matched controls (AMC). Within the total lymphocyte compartment, apoptosis was more pronounced in DS; it increased with age. Moreover, apoptosis was highest within the B‐lymphocyte compartment which may be a contributing factor to the B‐lymphocytopenia found in DS. Pediatr Blood Cancer 2012; 59: 1310–1312. © 2012 Wiley Periodicals, Inc.