bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Experience of Interprofessional Collaboration in a Telehealth Context in Primary Care: The Perspective of Patients Living with a Chronic Illness – A Research Protocol
Authors: Mcgraw Monica , Couturier Yves , Gaboury Isabelle , Poirier Marie-Dominique , Poitras Marie-Eve 
Published: June 2024

Abstract

Background: The enhancement of primary health care and the prevalence of chronic diseases are key issues worldwide, especially in Canada. As the incidence of chronic illnesses rises, they have emerged as the foremost cause of mortality worldwide. This trend has led to a surge in demand for healthcare services, placing significant pressure on primary care systems. In 2019, with the arrival of the pandemic, the rapid introduction of telehealth emerged as a crucial resource for patients with chronic illnesses, augmenting the role of primary healthcare as their initial point of contact. This resource was implemented with no infrastructure, often without patient support, and left to the discretion of individual professionals. Interprofessional collaboration plays a critical role in optimizing the use of telehealth in managing chronic diseases. Interprofessional teams can provide comprehensive care that addresses the multifaceted needs of patients with chronic illnesses. This approach ensures that patients receive holistic and coordinated care, leading to better health outcomes. Despite its advantages, telehealth can have negative effects if used sub-optimally.
Methods/design: To describe the process of interprofessional collaboration in the telehealth context in primary care coming from the perspective of patients living with chronic disease, this qualitative research is based on a constructivist research methodology, where the research team constructs knowledge derived from the interpretation of information obtained during the interviews with participants. To meet the study's objectives, qualitative Journey Mapping data collection will be carried out, following the approach of Trebbel. Individual interviews will be analyzed qualitatively and iteratively. This method is useful for analysis being done by different people from the team, including those with little experience in qualitative analysis.
Anticipated benefits: The health and well-being of patients is central to the practice of healthcare professionals in primary care. Patients living with chronic diseases are among the most frequent users of primary care in Canada. The results of this study will support and improve the interprofessional collaboration process in the telehealth context, using a patient-centered approach. Journey mapping will help identify potential facilitating factors for improving primary care in the telehealth context according to the patient's journey. Results will be used to build a practical guide (phase 2) supporting interprofessional collaboration in the primary care telehealth context.
Type of Manuscript: Case Report Massive Cerebellar Infarction Caused by Spontaneously Isolated Posterior Inferior Cerebellar Artery Dissection: A Case Report
Authors: Huang Xuming , MMed Yuqi Liao , Wu Jiarui , Cao Liming 
Published: June 2024

Abstract

Background
Diagnosis of posterior inferior cerebellar artery dissection (PICAD) based on radiological images is difficult. Massive cerebellar infarctions caused by spontaneous isolated PICAD are rare and the relevant clinical, imaging, and treatment options are unclear.
Case presentation:
A 39-year-old man was admitted with dizziness, an unstable gait for two days. Physical examination showed decreased muscle strength in the right limb and right-sided ataxia. Brain magnetic resonance imaging (MRI) showed a massive acute right cerebellar infarction but other modalities including head and neck computed tomographic angiography (CTA) and magnetic resonance angiography (MRA) showed no obvious abnormalities. High-resolution vessel wall MRI (HR-VW-MRI) revealed right PICAD. The patient was diagnosed with massive cerebellar infarction caused by PICAD and began active conservative treatment. The initial PICAD lesion disappeared 1.5 months after discharge. The patient experienced only slight weakness in the right limb by 3 months.
Conclusions
Since MRA or CTA may fail in identifying PICAD, HR-VW-MRI is key in diagnosis and follow-up evaluation. Aggressive medication may be effective and safe for PICAD.
Sex-Specific Risk Factors and Clinical Dementia Outcomes for White Matter Hyperintensities in a large South Korean Cohort
Authors: Schweitzer Noah , Son Sang Joon , Thurston Rebecca C. , Li Jinghang , Chen Chang-Le , Aizenstein Howard , Yang Shaolin , Iordanova Bistra , Hong Chang Hyung , Roh Hyun Woong , Cho Yong Hyuk , Hong Sunhwa , Nam You Jin , Lee Dong Yun , Park Bumhee , Kim Na-Rae , Choi Jin Wook , Cheong Jaeyoun , Seo Sang Woon , An Young-Sil , Moon So Young , Han Seung Jin , Wu Minjie 
Published: June 2024

Abstract

Objective:
White matter hyperintensities (WMH) on brain MRI images are the most common feature of cerebral small vessel disease (CSVD). Studies have yielded divergent findings on the modifiable risk factors for WMH and WMH’s impact on cognitive decline. Mounting evidence suggests sex differences in WMH burden and subsequent effects on cognition. Thus, we aimed to identify sex-specific modifiable risk factors for WMH. We then explored whether there were sex-specific associations of WMH to longitudinal clinical dementia outcomes.
Methods:
Participants aged 49–89 years were recruited at memory clinics and underwent a T2-weighted fluid-attenuated inversion recovery (FLAIR) 3T MRI scan to measure WMH volume. Participants were then recruited for two additional follow-up visits, 1–2 years apart, where clinical dementia rating sum of boxes (CDR-SB) scores were measured. We first explored which known modifiable risk factors for WMH were significant when tested for a sex-interaction effect. We additionally tested which risk factors were significant when stratified by sex. We then tested to see whether WMH is longitudinally associated with clinical dementia that is sex-specific.
Results:
The study utilized data from 713 participants (241 males, 472 females) with a mean age of 72.3 years and 72.8 years for males and females, respectively. 57.3% and 59.5% of participants were diagnosed with mild cognitive impairment (MCI) for males and females, respectively. 40.7% and 39.4% were diagnosed with dementia for males and females, respectively. Of the 713 participants, 181 participants had CDR-SB scores available for three longitudinal time points. Compared to males, females showed stronger association of age to WMH volume. Type 2 Diabetes was associated with greater WMH burden in females but not males. Finally, baseline WMH burden was associated with worse clinical dementia outcomes longitudinally in females but not in males.
Discussion:
Elderly females have an accelerated increase in cerebrovascular burden as they age, and subsequently are more vulnerable to clinical dementia decline due to CSVD. Additionally, females are more susceptible to the cerebrovascular consequences of diabetes. These findings emphasize the importance of considering sex when examining the consequences of CSVD. Future research should explore the underlying mechanisms driving these sex differences and personalized prevention and treatment strategies.
Clinical trial registration: The BICWALZS is registered in the Korean National Clinical Trial Registry (Clinical Research Information Service; identifier, KCT0003391). Registration Date 2018/12/14.
A comprehensive evaluation of the long-term trend of the basic climatic variables and the net water available (NWA) index in Iran during the period from 1960 to 2020
Authors: Rezaee Ali , Mosaedi Abolfazl , Beheshti Aliasghar , ZArrin Azar 
Published: June 2024

Abstract

In recent years, the effects and consequences of climate change have shown themselves by creating irregularities and trends in the essential climatic variables. In most cases, the trend of climatic variables is associated with periodicity. In this study, the trends and periodicity of these data (precipitation, temperature, evapotranspiration, and net available water (NWA) have been investigated in a period of 60 years in Iran. The Mann-Kendall trend test and Sen’s slope estimator are applied for analyzing the trend and its magnitude. Wavelet transform is used to detect the periodicity of time series and to determine the correlation between NWA and temperature, precipitation, and evapotranspiration in common periodicity. The results show that the stations located in eastern and western Iran have more significant increasing/decreasing trends. Evapotranspiration shows the highest increasing trend in most stations, followed by temperature, while NWA and precipitation have trends at lower significance levels and decreasing direction. The examination of periodicity in time series showed that, among all the studied stations, evapotranspiration has the most extended periodicity with an average length of 8.3 years, followed by NWA, temperature, and precipitation with 7.3 years, 5.8 years, and 5.5 years. The results of the correlations investigation showed that in about 80% of the stations, there is a high correlation between precipitation and NWA in the short-term periodicity and at the end of the studied period. The evapotranspiration variable in most stations has a high correlation in different periodicities with the amount of NWA.
A Non linear curve relating Anion Gap to AKI progression among AKI patients Complicated With COPD Within 14 days :a retrospective cohort study from Dyrad database
Authors: Lv Yunyun , Hu Ruimin , Wang Yaotang 
Published: June 2024

Abstract

Background
Current evidence on the relationship between anion gap and AKI progression is insufficient. Further investigation is necessary to validate this relationship.
Objective
The primary aim is to gain a deeper understanding of how anion gap influences AKI progression and its implications. The secondary objective is to examine the combined effects of anion gap and interacting factors on AKI progression outcome by constructing cox model and threshold analysis.
Methods
A retrospective cohort study involving 1868 participants from the Dyrad database was conducted. Data from all participants were analyzed to investigate meaningful covariates, including physical signs, laboratory items, diseases, and SOFA score. Cox regression, smooth curve fitting, and threshold analysis were used for analysis.
Results
The overall incidence of AKI progression was 12.6% in group1 (AG < 16) and 27.2% in group2. Lower eGFR and chloride levels were observed in group1 compared to group2. After multivariate adjustment, a significant association between anion gap and the risk of AKI progression was observed (HR = 1.05, 95%CI = 1.03–1.08, P < 0.001, Model 3). Multivariate smooth splines analysis indicated a nonlinear relationship between anion gap and AKI progression (P for nonlinearity = 0.02). Threshold analysis showed an 8% increase in the risk of AKI progression when AG exceeded the inflection point of 12.
Conclusions
Our findings suggest that anion gap level is associated with AKI progression. A nonlinear association was revealed, indicating that higher AG levels are linked to an increased risk of progression in AKI patients with COPD when AG is greater than 12. Further validation and confirmation of these findings are necessary.
May Measurement Month 2022: An Analysis of Blood Pressure Screening Findings from Sierra Leone
Authors: Jalloh Mohamed Bella , Williams Christine E.E. , Jegede Oluwanfunmike G. , Malijan Greco M. B. , Naveed Asad , Kanu Alieu , Bah Abdul K. , Jalloh Fatima , Jalloh Abubakar , Faulkner Monalisa M.J. , Agboola Kehinde , Baldeh Mamadu , Russell James B.W. , Oladapo Olulola O. 
Published: June 2024

Abstract

Introduction
Elevated blood pressure, a major modifiable risk factor for death and disability globally, remains a significant public health challenge despite increased knowledge of preventive measures. Its high prevalence and underdiagnosis, particularly in low-resource settings, necessitate effective interventions.
Methods
The May Measurement Month (MMM) initiative by the International Society of Hypertension (ISH) aims to raise awareness and promote screening programs. This study presents the findings of the MMM 2022 in Sierra Leone. We conducted an opportunistic cross-sectional study in Sierra Leone from May to September 2022, enrolling 818 participants aged 18 or older.
Results
Among the participants (mean age 38.0 years, predominantly Black), the prevalence of hypertension was 25.7% (210 out 818 participants). However, only 17% (140 out of 818) of the participants were previously diagnosed with hypertension. The findings revealed a wide range of antihypertensive medication use among the known hypertensives, ranging from no medication to the use of five or more medication classes. Approximately 43.6% of the known hypertensives were taking one antihypertensive medication, while 22.9% were taking two medications. A significant proportion, 42.9%, of the known hypertensives did not consistently adhere to their antihypertensive medication regimen, citing common reasons such as cost, availability, side effects, and forgetfulness.
Conclusion
This study highlights the importance of community-based screening in identifying undiagnosed hypertension and emphasizes the need for expanded or alternative screening and referral programs to increase awareness, promote preventive measures, and improve hypertension management in Sierra Leone.
Comparative Analysis of Adjuvant Radiotherapy, Lymph Node Dissection, and Metastatic Positive Rate on Prognosis in T3-4N+ Gastroesophageal Junction Cancer: A Study Based on SEER Database and External Validation in China
Authors: tian chenrui , Yu Haodi , Zhang Qingyu , Cang Shundong 
Published: June 2024

Abstract

Background
Adjuvant radiotherapy (ART) is recognized as a pivotal therapeutic modality capable of augmenting the overall survival(OS) outcomes in patients afflicted with gastroesophageal junction cancer (GEJ) at the T3-4N+ stage. However, there remains a need for comprehensive investigations into the optimal timing of radiotherapy administration relative to surgery. Furthermore, the number of regional nodes examined(RNE) and the metastasis lymph node ratio (MLR) exert discernible impacts on the prognosis of such patients. Our study endeavors to delve deeper into elucidating the interplay between ART and surgical interventions, while assessing the prognostic significance of RNE and MLR, with the ultimate goal of developing a nomogram to accurately predict the 5-year survival rate for T3-4N+ gastric cancer patients.
Patients and Methods
7,709 patients with GEJ cancer were involved from the Surveillance, Epidemiology, and End Results (SEER) database, spanning 2010 to 2019. 335 gastric cancer patients were involved from the Henan Provincial People's Hospital (HPPH), spanning 2015 to 2019. OS was analyzed using the log-rank test and multivariate analysis. The Cox regression models were valuable in predicting outcomes for these cancers. Receiver operating characteristic curve (ROC) and Decision Curve Analysis (DCA) were used to validate predictive model. Restricted cubic splines (RCS) were employed to analyze the potential nonlinear relationship between RNE and prognosis. Additionally, the relationship between MLR and prognosis was examined using the same method.
RESULTS
We found that esophageal adenocarcinoma exhibited a superior response to preoperative radiotherapy(p<0.001). However, the timing of radiotherapy for gastric adenocarcinoma post-operation did not significantly affect outcomes (p=0.6). Age, tumor grade, lymph node stage, RNE, type of surgery, and timing of radiotherapyrelative to surgery emerged as crucial prognostic factors for T3-4N+ gastric cancers. Additionally, the analysis showed no significant nonlinear relationship between RNE (with a threshold of 15) and patient survival in esophageal and gastric adenocarcinomas (p>0.05), suggesting consistent findings across varying levels of lymph node removal.
CONCLUSIONS
Esophageal adenocarcinoma demonstrates a greater therapeutic response to preoperative radiotherapy. Our nomogram provides an effective tool for predicting the 5-year prognosis of T3-4N+ gastric adenocarcinoma. Moreover, our analysis suggests that the removal of 15 lymph nodes may not represent the optimal strategy for lymph node dissection. Additionally, MLR emerges as a significant prognostic factor influencing outcomes in patients with both esophageal and gastric cancer.
Assessment of sweet whey fortified with selenium and Bifidobacteria on reduction of pesticide liver toxicity in albino rats
Authors: Moawad Raghda M.S. , Osman Ali H.A. , Hassanein Khaled M. A. , Elkot Wael F. , Asar Ahmed Mahmoud , Hafiz Halah , AlFaris Nora A. , AL-Farga Ammar , Zaidalkilani Ayah T. , Hassan Hanaa M. 
Published: June 2024

Abstract

Background
Deltamethrin (DLM) represents one of the most commonly used pesticides. DLM passes through milk, vegetables, and fruits to humans or through animals (veterinary drugs and feeding on contaminated forage) to milk; it can escape from skin to blood and be secreted in breast milk in lactating women. It was believed to have neurotoxic, nephrotoxic, and hepatotoxic properties.
Methods
In order to investigate deltamethrin-induced hepatotoxicity, 64 rats were divided into 8 groups. The control group did not receive any treatment. D 30 mg/kg DLM (body weight) dissolved in corn oil, B 1 mL whey (1010 cfu/ml of Bifidobacterium logum ATCC 15707), S 1 mL whey (0.5 ppm selenium), BS 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707 + 0.5 ppm selenium), BD 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707 + DLM), SD 1 mL whey (0.5 ppm selenium) + DLM, and BSD 1 mL whey (1010 cfu/mL of Bifidobacterium logum ATCC 15707) + 0.5 ppm selenium + DLM.
Results
Results marked that manipulation of bifidobacteria, or selenium triggered significant improvement in AST, ALT, GSH, TNF-α, NF-KB and BCL2 as well as reduction in histopathological necrosis, congestion, and degradation.
Conclusion
Whey beverage fortified with Bifidobacterium longum and selenium implicated reduction in oxidative stress, histopathological degradation that accomplished DLM toxicity. Utilization of whey (a byproduct from cheese making) is considered a recycling process which supports ecofriendly practices and sustainability.
Preparation and characterization of sodium-ion conducting biopolymer electrolyte membrane based on agar-agar with sodium nitrite for primary Na-ion battery.
Authors: Sowmiya S , Shanthi C 
Published: June 2024

Abstract

Utilizing a solution-casting approach with water as the solvent, agar-agar solid biopolymer membranes incorporating sodium nitrite at various molecular ratios were successfully synthesized. Characterization of these membranes was conducted using techniques including X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), AC Impedance techniques, Transference number measurements, and Linear sweep voltammetry (LSV). XRD analysis revealed the amorphous nature of the membranes, while FTIR elucidated the complexation behavior between the polymer and salt. DSC analysis indicated a decrease in the glass transition temperature with increasing salt concentrations up to a specific value. TGA was employed to assess the thermal stability of the polymer electrolyte membrane. The conductivity of pure agar-agar was found to be 3.12 X 10− 7 S cm− 1, and the maximum ionic conductivity, observed at room temperature, reached 5.07 X 10− 3 S cm− 1 for the membrane with a composition of 30% agar: 70% NaNO2. Transference number measurements, conducted using Wagner's DC polarization technique, provided insights into the nature of charge transport within the membrane. The electrochemical stability, determined through linear sweep voltammetry, was observed to be 2.8 V. Furthermore, the highest conductivity polymer electrolyte was employed in the fabrication of a primary sodium ion battery, incorporating two types of cathodes- V2O5 and MnO2. The resulting batteries exhibited open circuit voltages of 3.02 and 2.69 for V2O5 and MnO2 cathodes, respectively.
Critical resistance to carbapenem and aminoglycosides in Pseudomonas aeruginosa: Spread of bla NDM /16S methylase armA harboring isolates with intrinsic resistance mechanisms in Kerman, Iran
Authors: Soltani Behnaz , Ahmadrajabi Roya , Kalantar-Neyestanaki Davood 
Published: June 2024

Abstract

Background: Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is the one of the main Gram-negative bacterium cause of infections in hospital settings and the spread of them is significant challenge to public health.
Methods: In this study, a total of 30 non-duplicate isolates of CRPA were collected. Antibacterial susceptibility of bacteria to antibiotic agents and AmpC overproducer isolates were determined. Minimal biofilm inhibitory concentration (MBIC) of isolates to cefepime (FEP), imipenem (IPM), ceftazidime (CAZ), and meropenem (MEM) were evaluated with/without cloxacillin (CLX). The carbapenemase and 16S rRNA methylase genes were identified by PCR and the transcription levels of oprD, ampC, and mexA genes were determined by quantitative real-time PCR. ERIC-PCR was used to detect genetic relationships among the isolates.
Results: All isolates were resistance to IPM, MEM, CAZ, FEP, CIP, GEN, TOB and strong biofilm producer. The resistance genes including blaNDM, blaIMP, blaVIM, blaSIM, blaGES, and armA were detected in 21 (70%), 6(20%), 3 (10%), 2 (6.6%), 1 (3.3%), and 56.6% of the isolates, respectively. CLX at 250 and 500 µg/mL significantly reduced the level of MIC to MEM, IPM, CAZ, and FEP and at 2000 µg/mL significantly reduced the level of MBIC to MEM, IPM, CAZ, and FEP. In all of isolates the transcription levels of oprD were significantly downregulated as well as were showed significantly increasing for ampC and mexA. ERIC-PCR typing results divided 30 isolates into four clusters.
Conclusion: In this study we reported the spread of different clone of CRPA harboring co-existence various carbapenemase genes with armA 16S rRNA methylase for the first time in Kerman, Iran. Also, our isolates had a combination of resistance mechanisms to carbapenems as well as biofilm formation along with resistance to aminoglycosides, the further spread of which could cause serious challenge in hospital settings. Therefore, serious monitoring is necessary to reduce their prevalence in our hospital.
An extracorporeal and finely adjustable Pringle maneuver instrument for Laparoscopic Mesohepatectomy
Authors: Chu Hongpeng , Chen Longjiang , Wang Xu , Fang Xiaosan , Han Meng , Wang Guannan , Jiang Yaqi , Wang Xiaoming 
Published: June 2024

Abstract

Background
Laparoscopic mesohepatectomy remains in the exploratory stage because it is difficult to perform. Bleeding control is crucial for a successful operation. Our medical center has designed blocking forceps to perform the Pringle maneuver. This study aimed to investigate the value of these novel blocking forceps in laparoscopic mesohepatectomy.
Methods
Data from patients with malignant liver tumors who underwent laparoscopic mesohepatectomy between July 2017 and June 2022 were retrospectively collected. Patients who underwent the Pringle maneuver using novel blocking forceps were selected. The baseline data of all patients and the data of perioperative laboratory tests, imaging, and surgery-related parameters were statistically analyzed.
Results
All 61 patients who met the screening criteria underwent laparoscopic mesohepatectomy using novel blocking forceps for the Pringle maneuver. A total of 4 patients underwent an open surgery. Times of blocking was 2.92 ± 2.17, and the duration of blocking was 42.74 ± 33.00 minutes. Blood transfusions were performed in 6 patients, of whom 566.67 ± 150.55 ml were administered. All the patients underwent R0 resection. The complication rate was 8.2% in all cases. No deaths occurred.
Conclusion
Our designed blocking forceps for the Pringle maneuver in laparoscopic mesohepatectomy is conducive to the successful completion of surgery.