bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS KEBIJAKAN GAJI GURU HONORER TERHADAP KESEJAHTERAAN HIDUP GURU HONORER DI INDONESIA
Authors: Dhobith Anwar 
Published: June 2024

Penelitian ini bertujuan untuk membahas kebijakan guru honorer dalam rangka mengetahui desain kebijakan pemerintah dalam pengelolaan guru honorer di Indonesia dan dampak pengelolaan gaji guru honorer terhadap kesejahteraan guru honorer di Indonesia. Penelitian ini menggunakan metode telaah kepustakaan dan literatur yang mencakup buku, artikel, dan data yang telah dipublikasikan untuk mengkaji kebijakan terkait guru honorer. Hasil penelitian menunjukkan bahwa desain kebijakan pemerintah terkait guru honorer agar mendapatkan kesejahteraan yang seharusnya melalui PP No. 48 Tahun 2005 yang ditargetkan selesai pada tahun anggaran 2009 mengalami kendala sehingga dilakukan perubahan pada beberapa ketentuan yang akhirnya menerbitkan PP No. 43 Tahun 2007. Keluarnya UU No. 5 Tahun 2014 yang berfokus mengatur mengenai pegawai non-PNS, namun dalam implementasinya masih sering terjadi saling tumpang tindih dan belum menunjukkan sinergi yang efektif, meskipun arah kebijakannya sejalan, dan malah memunculkan persoalan baru terkait gaji guru honorer. Dampak yang muncul adalah kesenjangan antara gaji guru honorer dengan PNS maupun pegawai kontrak yang sangat signifikan padahal memiliki beban kerjan yang sama. Perlunya kebijakan pemerintah yang mengatur regulasi tentang gaji guru honorer agar kesejahteraan guru honorer bisa tercapai.
Bir Savaşı Anlatmak: Kralın ve Şairin Gözünden İnabahtı Savaşı
Authors: YENİ Seda ERKOÇ 
Published: June 2024

Papa V. Pius önderliğinde birleşmiş olan İspanyol ve Venedik kuvvetlerinin 1571 yılında, Osmanlı İmparatorluğu karşısında İnabahtı Savaşı’nda kazandıkları zafer, Hristiyan dünyasında büyük bir şaşkınlık ve coşku yaratmış; Avrupalı güçlerin bir araya geldiklerinde Osmanlılar karşısında ne derece etkin olabileceklerini gösteren bir başarı öyküsü olarak pek çok edebî eserlerde işlenmiştir. I. James’in 1591’de yayımlanan “The Lepanto” şiiri ve Richard Knolles’un 1603 tarihli General History of the Turks eseri, erken modern dönem İngiltere’sinde İnabahtı Savaşı’nı ele alan ve yazıldıkları dönemde geniş kitlelere ulaşmış iki metindir. İngiliz kralı I. James’in ve Richard Knolles’un İnabahtı Savaşı anlatılarına ve bu anlatılarda üretilen öteki imgesine odaklanan bu makale, erken modern dönem İngiltere’sinde üretilmiş belli metinlerde ortaya çıkan görece olumlu Türk imgesinin dönemin tüm eserleri için genellenemeyeceği görüşünü savunmaktadır. Aynı askerî mücadeleyi anlatmaları sebebiyle seçilmiş bu iki eserin yakın okuması, erken modern dönemde öteki kavramının Doğu-Batı/Müslüman-Hristiyan/İngiliz - Osmanlı ikili karşıtlıkları yerine İngiliz - Osmanlı - İspanyol/Protestan - Müslüman - Katolik üçgeni ve bu üçgenin ortaya çıkardığı karmaşık imgeler ekseninde değerlendirilmesi gerektiğini ortaya koyar. 16. yüzyılda İngiltere ile Osmanlı İmparatorluğu arasında yaşanan ekonomik gelişmelerle birlikte Osmanlı toplumu İngiliz düşünce dünyasında önemli bir yer tutmaya başlamıştır. Kraliçe I. Elizabeth’in Osmanlı İmparatorluğu ile ticari anlaşmalar yapma yolundaki adımları, Osmanlıların erken modern dönem İngiltere zihin dünyasında birbirinden oldukça farklı ve hatta birbiriyle çelişen imgelerle yer etmesine sebep olur. Bir yandan tüm Hristiyan dünyasının düşmanı olarak görülen Osmanlılar öte yandan Katolik dünyadan dışlanmış ve yeni ortaklar arayışına girmiş İngiltere’nin destekçisi rolünü üstlenmiştir.
Bu durum, dönemin edebî metinlerinde de Osmanlı imgesinin çeşitleneceği anlamına gelir. Dahası, bu dönem metinlerinde Osmanlı imgesi sadece İngiliz /Batılı/ Hristiyan – Osmanlı /Doğulu /Müslüman ikili karşıtlığı ekseninde kurulmamıştır. Erken modern dönem İngiltere’sindeki Osmanlı imgesini Doğulu-Batılı ikili karşıtlığı yerine İngiliz /Protestan – Avrupa /Katolik – Osmanlı /Müslüman üçgeninde okumak, metinlerdeki imgelerin daha doğru anlaşılmasını sağlayacaktır. İngiliz kralı I. James’in ve Richard Knolles’un İnabahtı Savaşı anlatılarının yakın okuması bu metinlerde Türklerin ve İspanyolların resmedilişine bu açıdan yaklaşmaktadır. I. James’in şiirinin ikinci basımında yaptığı değişikliklerle bir Katolik zaferini övdüğü türünden eleştirilere cevap vermeye çalışması ve Knolles’un eserinde bir yandan “Doğulu öteki”nin zulmünü detaylandırırken kendisi için Batılı öteki olan İspanya’yı ve Katolik dünyasını övmekten itinayla uzak durması, erken modern dönem İngiltere’sinde Batı/ Hristiyan algısının da homojen, yekpare olmadığının göstergesidir.
Development technology of functional dairy product with phytocomponents
Authors: Tsisaryk O. , Musii L. , Slyvka I. , Lutsyk I. 
Published: June 2024

The development of enriched fermented milk products is an actual direction of the food industry at the present time. The aim of the work was to develop a technology, to investigate the properties and quality indicators of the dairy product using hawthorn fruits, grape seed oil (GSO) and lactulose syrup. Organoleptic, physicochemical and microbiological parameters of the dairy product were carried out in the laboratory of the Department of Technology of Milk and Dairy Products. Starter FD DVS ABY-3 (CHR Hansen, Denmark) containing in its composition Lactobacillus acidophilus La-5, BB-12, Lactobacillus delbrueckii subsp. bulgaricus, Streptococcus salivarius subsp. thermophilus was used for the production of the dairy product. The qualitative indicators of functional components corresponded with regulatory legal acts: lactulose syrup – TU 9229-032-53757476-14; dry hawthorn fruits – TU 9185-055-14721358; grape seed oil – TU 9158-006-23199493-14. The dairy product was produced by the thermostatic method. GSO and lactulose syrup were added before pasteurization, and hawthorn extract before fermentation. The sequence of technological operations for the production of a functional fermented milk product: acceptance and assessment of the quality of the main and additional raw materials; normalization by mass fraction of fat to 2.5 %, adding of GSO and prebiotics; pasteurization of the mixture at a temperature of 90-95 °C with a holding time of 2–3 s, cooling to a temperature of 40 ± 2 °C; introduction of hawthorn fruit extract; introduction of leaven FD DVS ABY-3; packaging of the mixture; fermentation t = 40 ± 2 °C during 5 hours; cooling the product to a temperature of 4 ± 2 °С; product storage. The finished product was analyzed for relevance to the requirements of the DSTU 4343:2004. “Yogurts. General technical conditions”. The titrated acidity was determined titrometrically. Microbiological parameters of the product were studied according to DSTU IDF 117B:2003 “Yogurt. Determination of the number of characteristic microorganisms. The method of counting colonies at a temperature of 37 °C”. A comprehensive quality assessment was conducted and it was established that the functional product has higher organoleptic indicators and nutritional value; a greater number of lactic acid bacteria, which provides a high physiological value. Based on the research results, it is proposed to introduce functional ingredients for the technology of fermented milk products with functional properties: hawthorn fruits – 5.0 %, grape seed oil – 1 %, lactulose syrup – 0.5 %.
La semiología en medicina
Authors: Tello Esparza Adolfo 
Published: June 2024

La semiología es una herramienta que se utiliza en distintas profesiones, en el caso de la medicina es fundamental para la correcta obtención de información clínica, analisis, conclusión de diagnósticos e incluso elaborar el pronóstico que le espera a nuestro paciente.
Aunque se practica desde la medicina griega, su enseñanza se estandarizó desde hace relativamente poco tiempo, pero sin duda todos los médicos debemos esforzarnos por practicar una buena semiología, pues es crucial para lograr ser un buen clínico.
Archaeological and Early Historical Interests of Mykhailo Hrushevsky: Receptive Aspect
Authors: Telvak Vitalii , Yanyshyn Bohdan , Nakonechnyi Volodymyr 
Published: June 2024

The purpose of the research paper is to summarize a wide range of issues of an archaeological and early historical nature, actualized in the reviews of M. Hrushevsky.
The scientific novelty of the study is in the first special attempt at a complex reconstruction of archaeological and early historical subject matters of M. Hrushevsky’s heritage.
Conclusions. The scope of M. Hrushevsky’s archaeological interests is noted. Having been trained by V. Antonovych in archaeology, having practical experience in field excavations, and creating platforms for professional communication in the form of museums and journals, the scholar formed a panoramic vision of the achievements and problems of contemporary science. The picture of the state of archaeology in the late 19th – early 20th century offered by him was characterized by academic correctness, the accuracy of critical observations, and the innovative nature of proposals. He strived for the disciplinary modernization of Eastern European archaeological science, which, according to the reasoned opinion of M. Hrushevsky, was delayed at the stage of forming an empirical base. Of particular importance at the time was the scholar’s defense of Ukrainian archaeological interests in typologizing the historical cultures in our ethnic lands in a polemic with Russian, Polish, and Western European colleagues. Such activity had a considerable public impact and was an organic component of the scholar’s struggle for recognition of the academic rights of Ukrainian science.
In general, today, most of M. Hrushevsky’s observations, expressed in discussions with fellow archaeologists, are mainly of historiographical interest. However, his calls to avoid haste in the classification of archaeological material, to interpret it in the widest possible cultural context, to select reflectively a theoretical and methodological array of tools, and to treat artifacts of the past with responsibility are relevant guidelines for Ukrainian science even nowadays.
Greater working memory in cochlear implant users is related to higher subjective quality of life
Authors: Prince Priyanka , Chen Joseph , Le Trung , Lin Vincent , Dimitrijevic Andrew 
Published: June 2024

IntroductionA common concern for individuals with moderate-to-profound hearing loss who have received a cochlear implants (CIs) is difficulty following conversations in noisy environments. A possible reason is the increased use of cognitive resources (attention and working memory) to disambiguate the speech stimuli potentially causing detriments in functional aspects of life. However, this relationship is not well-documented. The overall arching goal of this study was to quantify the relationships between Patient-Reported Outcome Measures (PROMs) and cognitive ability through working memory and speech perception measures.MethodsIn the current study, 31 adult CI users and typical hearing (TH) age-matched controls were recruited. CI users completed PROMs including Speech, Spatial and Quality of hearing survey (SSQ) and versions of a quality of life (QOL) for CI users (CIQOL) and Nijmegen Cochlear Implant Questionnaire (NCIQ). Measures of cognition were assessed using internet-based tools. Outcomes were compared between groups and PROMs and were related to the cognitive tasks.ResultsReduced auditory working memory and speech perception in noise were observed in CI users compared to TH controls. Correlation analyses revealed significant domain-specific PROM relationships with cognitive tasks in CI users, but not in TH controls. The SSQ had more significant relationships compared to the other PROMS.ConclusionThese results suggest that internet-based metrics of cognitive ability are associated with the functional hearing aspects of life in CI users and that SSQ is more sensitive to investigate the cognitive related effects of QOL compared to other commonly used PROMs.
The type of COVID−19 vaccination does not affect reproductive function and pregnancy outcomes in infertile couples
Authors: Wang Shiming , Wang Ningning , Yao Guidong , Su Yingchun , Qi Lin 
Published: June 2024

IntroductionStudies on the effect of vaccine type and two other vaccines other than inactivated vaccines approved in China on in vitro fertilization (IVF) pregnancy outcomes are rare. To complement and confirm the existing findings, this research aimed to investigate whether there are adverse effects of different vaccine types in females and males on reproductive function and clinical pregnancy.MethodsThis retrospective study enrolled 6,455 fresh embryo transfer cycles at the First Affiliated Hospital of Zhengzhou University between May 1, 2021, and October 31, 2022. The primary outcome is the clinical pregnancy rate (CPR). At the same time, the secondary results are the number of oocytes retrieved, two pronuclei (2PN) rate, blastocyst formation rate, high-quality blastocyst rate, and semen parameters (volume, density, sperm count, forward motility rate, total motility rate, immobility rate, and DNA fragment index (DFI) rate).ResultsIn the comparison of ovarian stimulation indicators, no statistically significant differences (P &gt; 0.05) were found in Gn days, endometrial thickness, 2PN rate, metaphase 2 (MII) rate, high-quality embryo rate, and blastocyst formation rate. No significant differences (P&gt;0.05) were found in age, body mass index (BMI), education level, and semen parameters (volume, density, sperm count, forward motility rate, total motility rate, immobility rate, and DFI rate) in these four groups. The multivariate regression model showed that neither the types of vaccines nor the vaccination status of both infertile couples significantly affected clinical pregnancy.DiscussionThe type of vaccine does not appear to have an unfavorable effect on ovarian stimulation, embryo development, semen parameters, and clinical pregnancy.
Evaluation of a blood miRNA/mRNA signature to follow-up Lu-PRRT therapy for G1/G2 intestinal neuroendocrine tumors
Authors: Jacques Virginie , Dierickx Lawrence , Texier Jean Sebastien , Brillouet Severine , Courbon Frederic , Guimbaud Rosine , Vija Lavinia , Savagner Frederique 
Published: June 2024

Background177Lu-oxodotreotide peptide receptor therapy (LuPRRT) is an efficient treatment for midgut neuroendocrine tumors (NETs) of variable radiological response. Several clinical, biological, and imaging parameters may be used to establish a relative disease prognosis but none is able to predict early efficacy or toxicities. We investigated expression levels for mRNA and miRNA involved in radiosensitivity and tumor progression searching for correlations related to patient outcome during LuPRRT therapy.MethodsThirty-five patients received LuPRRT for G1/G2 midgut NETs between May 2019 and September 2021. Peripheral blood samples were collected prior to irradiation, before and 48 h after the second and the fourth LuPRRT, and at 6-month follow-up. Multiple regression analyses and Pearson correlations were performed to identify the miRNA/mRNA signature that will best predict response to LuPRRT.ResultsFocusing on four mRNAs and three miRNAs, we identified a miRNA/mRNA signature enabling the early identification of responders to LuPRRT with significant reduced miRNA/mRNA expression after the first LuPRRT administration for patients with progressive disease at 1 year (p &lt; 0.001). The relevance of this signature was reinforced by studying its evolution up to 6 months post-LuPRRT. Moreover, nadir absolute lymphocyte count within the first 2 months after the first LuPRRT administration was significantly related to low miRNA/mRNA expression level (p &lt; 0.05) for patients with progressive disease.ConclusionWe present a pilot study exploring a miRNA/mRNA signature that correlates with early hematologic toxicity and therapeutic response 12 months following LuPRRT. This signature will be tested prospectively in a larger series of patients.
Method optimization for benchtop mass spectrometry imaging of lipids in Eisenia hortensis
Authors: Selby Kendra G. , Korte Claire E. , Phan Lauren H. , Bressendorff Gabriel A. , Chirchirillo Ashley R. , Tucker Kevin R. 
Published: June 2024

Matrix selection and application is a crucial step in obtaining meaningful results with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI). Most instruments have a large spatial, and data with adequate spatial resolution can frequently be obtained on a benchtop instrument. The matrix application workflow has been optimized for the imaging of the earthworm (Eisenia hortensis), after exposure to various statins, a class of blood lipid-lowering agents. Lipids are nonpolar, often neutral molecules, making them difficult to ionize, and heightening the need for matrix optimization. The matrices 2,5-dihydroxybenzoic acid (DHB), α-cyano-4-hydroxycinammic acid (CHCA), 1,5-diaminonaphthalene (DAN), and 3,5-dimethoxy-4-hydroxycinnamic acid (sinapinic acid; SA) were studied. Samples were also washed in the ammonium salts of acetate, bicarbonate, formate, sulfate, or water as a control to enhance ionization and improve spatial resolution. A successful matrix for MSI is one that demonstrates homogenous tissue coverage, ionization of the analytes of interest, and does not require excessive laser power for ionization. All matrices showed sufficient tissue coverage; however, CHCA yielded unambiguous images of cholesterol and yielded sufficient signal over the lipid mass range (400–1,000 m/z), indicating that it successfully ionized endogenous lipids. Following additional optimization, the application of 50 mL of 10 mg/mL CHCA following a 5 s salt ammonium sulfate salt wash proved most successful for improving lipid ionization and enhancing spatial resolution.
An in vitro model system for testing chemical effects on microbiome-immune interactions – examples with BPX and PFAS mixtures
Authors: Fischer Florence , Pierzchalski Arkadiusz , Riesbeck Sarah , Aldehoff Alix Sarah , Castaneda-Monsalve Victor Alfonso , Haange Sven-Bastiaan , von Bergen Martin , Rolle-Kampczyk Ulrike Elisabeth , Jehmlich Nico , Zenclussen Ana Claudia , Herberth Gunda 
Published: June 2024

IntroductionMore than 350,000 chemicals make up the chemical universe that surrounds us every day. The impact of this vast array of compounds on our health is still poorly understood. Manufacturers are required to carry out toxicological studies, for example on the reproductive or nervous systems, before putting a new substance on the market. However, toxicological safety does not exclude effects resulting from chronic exposure to low doses or effects on other potentially affected organ systems. This is the case for the microbiome-immune interaction, which is not yet included in any safety studies. MethodsA high-throughput in vitro model was used to elucidate the potential effects of environmental chemicals and chemical mixtures on microbiome-immune interactions. Therefore, a simplified human intestinal microbiota (SIHUMIx) consisting of eight bacterial species was cultured in vitro in a bioreactor that partially mimics intestinal conditions. The bacteria were continuously exposed to mixtures of representative and widely distributed environmental chemicals, i.e. bisphenols (BPX) and/or per- and polyfluoroalkyl substances (PFAS) at concentrations of 22 µM and 4 µM, respectively. Furthermore, changes in the immunostimulatory potential of exposed microbes were investigated using a co-culture system with human peripheral blood mononuclear cells (PBMCs). ResultsThe exposure to BPX, PFAS or their mixture did not influence the community structure and the riboflavin production of SIHUMIx in vitro. However, it altered the potential of the consortium to stimulate human immune cells: in particular, activation of CD8+ MAIT cells was affected by the exposure to BPX- and PFAS mixtures-treated bacteria. DiscussionThe present study provides a model to investigate how environmental chemicals can indirectly affect immune cells via exposed microbes. It contributes to the much-needed knowledge on the effects of EDCs on an organ system that has been little explored in this context, especially from the perspective of cumulative exposure.
18F-FDG PET/CT semi-quantitative parameters combined with SCC-Ag in predicting lymph node metastasis in stage I-II cervical cancer
Authors: Jiang Cheng-Zhi , Zheng Kai , Zhang Yan-Yin , Yang Jian , Ye Hui , Peng Xiang 
Published: June 2024

ObjectiveTo explore the value of 18F-fluordeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) semi-quantitative parameters of primary tumor combined with squamous cell carcinoma antigen (SCC-Ag) in predicting lymph node metastasis (LNM) of cervical cancer (FIGO 2018 stage I-II).Materials and MethodsA total of 65 patients with stage I-II cervical cancer underwent 18F-FDG PET/CT were included in our study. Comparing the primary tumor 18F-FDG PET/CT semi-quantitative parameters and SCC-Ag between the LNM group and the non-LNM group. Logistic regression and receiver operating characteristic (ROC) were used to analyze the value of 18F-FDG PET/CT metabolic parameters and SCC-Ag in predicting LNM.ResultsThere were 14 and 51 patients were classified as having LNM and NLNM. The semi-quantitative parameters, including the maximum standardized uptake value (SUVmax), the mean standardized uptake value (SUVmean), the peak standardized uptake value (SUVpeak), the total lesion glycolysis (TLG), the metabolic tumor volume (MTV) of the tumor and SCC-Ag were all significantly higher in LNM than in NLNM (SUVmax, 16.07 ± 7.81 vs 11.19 ± 4.73, SUVmean, 9.16 ± 3.48 vs 6.29 ± 2.52, SUVpeak, 12.70 ± 5.26 vs 7.65 ± 3.26, MTV, 22.77 ± 12.36 vs 7.09 ± 5.21, TLG, 211.01 ± 154.25 vs 43.38 ± 36.17, SCC-Ag, 5.39 ± 4.56 vs 2.13 ± 2.50, all p&lt;0.01). Logistic regression analysis showed that TLG was an independent predictor of LNM in stage I-II cervical cancer (OR 1.032, 95% CI 1.013–1.052, p&lt;0.01). Moreover, the predictive value of TLG combined with SUVpeak and SCC-Ag increased and the area under the curve increased compared SUVpeak and SCC-Ag.Conclusion18F-FDG PET/CT semi-quantitative parameters and SCC-Ag have promise for assessing LNM in stage I-II cervical cancer. TLG of primary tumor provides independent and increasing values in predicting LNM in stage I-II cervical cancer.