bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein Metabolism in Chronic Severe Malnutrition (Kwashiorkor)
Authors: GÓMEZ F. , RAMOS‐GALVÁN R. , CRAVIOTO J. , FRENK S. , PEÑA CARMEN DE LA , MORENO MARÍA ELENA , VILLA MARÍA ELENA 
Published: August 2010

SummaryNitrogen balances were done on children affected with chronic severe malnutrition while on a diet of corn‐meal and beans with and without lysine and tryptophane supplements.Calculated as per cent of intake both absorption and retention of nitrogen were greater when the supplement was added to the basal diet.Du métabolisme protóique dans la sous‐alimentation chronique grave (Kwashiorkor).2. Influence des supplements amino‐acides sur l'absorption et la retention d'azotes dans le régime diététique au maïs et aux légumineuses.Chez des enfants souffrant de sous‐alimentation chronique grave, des balances ont étéétablies pendant un régime diététique de farine de maïs et des légumineuses, avec et sans suppléments de lysine et de tryptophane. Calculées en pourcentages de matière ingérée, l'absorption aussi bien que la rétention d'azotes ont été plus grandes lorsque le suppléement était ajoutó au régime fondamental.Eiweißstoffwechsel in schwerer chronischer Unterernährung (Kwashiorkor).2. Einfluss ergänzender Aminosäuren auf die Absorption und Retention von Stickstoff bei einer Mais‐und Bohnendiät.Stickstoffbilanzuntersuchungen wurden bei Kindern mit schwerer chronischer Unternährung, die an einer Maismehl‐und Bohnendiät mit und ohne Zusatz von Lysin und Tryptophan gehalten waren, durchgeführt. Es zeigte sich, dass sowohl die Absorption als auch die Retention von Stickstoff, ausgedrückt in Prozenten der Einnahme, grösser war, wenn die zugrundeliegende Diät die zusätzlichen Aminosäuren enthielt.Metabolismo proteico en la desnutrición crónica grave (Kwashiorkor)2. Influencia de los suplementos aminoácidos en la absorción y retención nitrogénicas bajo un régimen dietético de maíz y legurninosas.Estableciéronse balanzas nitrogénicas de niños afectos de desnutrición crónica grave, mientras quedaban sometidos a un régimen dietético de harina de maíz y leguminosas, con y sin suplementos de lisinas y triptófano. Calculadas en porcentajes de materia ingerida, tanto la absorción como la retención del nitrógeno, fueron mayores al ser añadido el suplemento a la dieta fundamental.
Untersuchungen über den Stromaprotein‐und Lipoidgehalt von Nabelschnurerythrozyten1
Authors: KÜNZER WILHELM 
Published: August 2010

ZusammenfassungDer Gesarntprotein‐, Gesamtcholesterin‐, Phosphorlipoid‐und Eisengehalt werden an je 10 Stromaproben aus Nabelschnur‐und Erwachsenenblut bestimmt. Bei Bezug auf 1,0 cm3 Erythrozytenbrei weisen die erhaltenen Werte für Nabelschnurery‐throcytenstromata von denjenigen für Erwachsenenerythrozytenstromata keine gesicherten Unterschiede auf.Investigations into the stromal protein and lipid level of erythrocytes in the umbilical cord.The total protein, total cholesterol, phospholipid and iron levels were determined each in 10 stromal samples of umbilical cord and adult blood. The values obtained per 1.0 ml erythrocyte pulp showed no definite difference between umbilical‐cord erythrocyte stromata and adult erythrocyte stromata.Recherches sur la teneur du stroma des érythrocytes du cordon ombilical en protéines et en lipides.Des déterminations du taux des protéines totales, du cholestérol total, des phospholipides et du fer ont été effectuées sur 10 échantillons de stroma provenant de sang prélevé dans des cordons ombilicaux ainsi que sur 10 échantillons de sang prélevés sur des personnes adultes. Par cm3 de pâte d'érythrocytes, les valeurs obtenues pour les stromas d'érythrocytes provenant de cordons ombilicaux ne s'écartèrent pas sensiblement de celles qui furent trouvées pour les stromas d'érythrocytes provenant du sang de personnes adultes.Investigaciones sobre el contenido proteico y lipoidico del estroma de los hematies del cordón umbilical.Se ha determinado el contenido en proteinas totales, colesterina total, fosfolípidos y hierro en 10 muestras de sangre procedente de cordón umbilical y de sujetos adultos. Los valores obtenidos para el estroma de los hematíes procedentes de cordón umbilical, en relación a I cc. de papilla de hematies, no presentan ninguna diferencia significativa con el estroma de los hematies del adulto.
THE VENOUS PLASMA FREE AMINO ACID LEVELS DURING THE FIRST HOURS OF LIFE
Authors: LINDBLAD B. S. 
Published: August 2010

SummaryDuring the first hours of extrauterine life the venous plasma of the fasting normal newborn shows a fast decline of valine, leucine, isoleucine, lysine and alanine levels, while the glycine level and the ornithine/arginine quotient seem to increase. These changes are not caused by urinary excretion and are the same as those found in calorie undernutrition.The fasting newborn of mothers with hypertension of pregnancy, who are underweight and short for gestational age, have increased levels of valine, leucine and isoleucine during the first hours after birth and a tendency towards a more rapid decline of the levels thereafter. The alanine and proline levels seem to “resist” the general decline during the initial fast. These changes in the homeostasis of plasma free amino acids are not due to short gestational period. They are the same as those found in protein deficiency.
ABNORMAL PATTERNS OF URINE AND SERUM AMINO ACIDS IN METHYLMALONIC ACIDEMIA
Authors: HALVORSEN S. , STOKKE O. , ELDIARN L. 
Published: August 2010

SummaryAbnormal patterns of serum and urine amino acids were found in our patient with the recently discovered inborn error Methylmalonic acidemia. The most distinct findings were increased serum and urine concentrations of lysine and glycine. In addition, the serum levels of leucine, isoleucine, valine, threonine and glutamic acid, and the urinary excretion of valine, threonine and ornithine were increased. Both the clinical picture and the amino acid patterns resemble those found in the ketotic form of Hyperglycinemia. Recent studies indicate that hyperglycinemia consists of at least two separate diseases, methylmalonic acidemia and propionic acidemia.
THE RESULTS OF IMMUNOSUPPRESSIVE THERAPY IN CHRONIC RENAL DISEASES IN CHILDREN AND THE ASSESSMENT OF ERYTHROBLASTS BEHAVIOUR
Authors: HALIKOWSKI B. , KUCHARSKA K. , GARWICZ S. , WYSZKOWSKI J. , SANCEWICZ‐PACH0 K. 
Published: August 2010

SummaryImmunosuppressive therapy (6‐Mercaptopurine) has been used in 33 children with chronic renal diseases resistant to other therapeutic methods. Peripheral blood counts were done in all the children and in 18 of them bone marrow examinations were performed.The results of immunosuppressive therapy were encouraging; many compleie and partial remissions being obtained.Children with nephrotic syndrome showed low percentages of erythroblasts in bone marrow. This was not observed in children suffering from chronic glomerulo‐ and pyelonephritis. Immunosuppressive therapy provoked increase of erythroblasts in bone marrow of children with nephrotic syndrome.
JEJUNAL MUCOSA IN INFANTILE MALNUTRITION
Authors: BERKEL İZZET , KIRAN ÖZDEN , SAY BURHAN 
Published: August 2010

SummaryTwenty‐six infants with malnutrition and seven controls were studied by routine haematological tests, serum protein levels, glucose tolerance and D‐Xylose absorption tests, jejunal biopsies and intestinal disaccharidase, assays. In conclusion, it can be said that in malnutrition the jejunal mucosa shows some mild or non‐specific histologic changes compatible with malabsorption, which may be reversible. No correlation could be shown between these changes and absorption tests. Malnutrition may also result in secondary intestinal disaccharidase deficiencies which improve with correction of the nutritional state. These secondary enzyme deficiencies may be responsible for some of the diarrhoeas seen in marasmic children. No direct correlation between anaemia, iron‐deficiency, folic acid levels, protein deficiency and intestinal mucosal changes could be established in this study.
CHROMOSOMAL CONDITIONS IN CONGENITAL HEART DISEASE
Authors: DAHL GUDRUN 
Published: August 2010

SummaryChromosome studies were made in 100 patients with congenital cardiovascular disease. Twelve patients had Down's syndrome with trisomy G. Four patients had Turner's syndrome with karyotype 45/XO. In one patixt, isozhromosomy or pericentric inverrion of the Y chromosome was found, and was also found in the paternal grandfather, the father and the brother, none of whom had malformations. One patient who also had severe extracardiac malformations, had partial trisomy of a group C chromosome and translocation C/D. Trans‐location C/D was found in the father and sister, who were phenotypically normal. In the remaining 82 patients, normal chromosomal conditions were found, although 2 patients had presumably insignificant chromosomal variations.
CYSTATHIONINURIA IN CHILDREN WITH NEUROBLASTOMA WITH AND WITHOUT METASTASIS
Authors: STUDNITZ WILFRIED v. 
Published: August 2010

SummaryCystathioninuria was demonstrated in 14 of 20 children (aged 1 month to 6 years) with neuroblastoma associated with increased cate‐cholamine production. In 4 of these 14 patients no metastasis could be detected. Two of the 6 children without cystathioninuria had metastasis. Cystathioninuria appeared to occur more frequent in children with neuroblastoma in the age below 1 year. Cystathioninuria in neuro‐blastoma is not an early sign of the disease and is not a reliable sign of metastasis.
HEREDITARY ECTODERMAL DYSPLASIA
Authors: SAMUELSON GÖSTA 
Published: August 2010

SummaryTwo case? of ectodermal dysplasia, diagnosed at the ages of 2 1/2 years and 7 months, are described. The main signs were hypodontia, hypotrichosis and hypo‐ or anhidrosis. In both cases the temperature instability was a pronounced clinical problem. In one of the two cases bilateral glaucoma was diagnosed at the age of 10 months.
OXIDATION OF GLUCOSE and D‐B‐OH‐BUTYRATE BY THE EARLY HUMAN FETAL BRAIN
Authors: ADAM PETER A. J. , RÄIHÄ NIELS , RÄHIALÄ EEVA‐LIISA , KEKOMÄKI MARTTI 
Published: August 2010

Abstract. Adam, P. A. J., Räihä, N., Rahiala, E.‐L. and Kekomäki, M. (Departments of Pediatrics, Case Western Reserve University at Cleveland Metropolitan General Hospital, Cleveland, Ohio USA, and the University of Helsinki at the Children's Hospital, Helsinki, Finland). Oxidation of glucose and D‐B‐OH‐butyrate by the early human fetal brain. Acta Paediatr Scand, 64:17, 1975.–The isolated brains of 12 previable human fetuses obtained at 12 to 21 weeks' gestation, were perfused through the interval carotid artery with glucose (3 mM) and/or DL‐B‐OH‐butyrate (DL‐BOHB), 4.5 mM, plus tracer quantities of either glucose‐6‐14C (G614C) or β‐OH‐butyrate‐3‐14C (BOHB314C). Oxidative metabolism was demonstrated by serial collection of gaseous 14CO2 from the closed perfusion system, and from the recirculating medium. Glucose and BOHB were utilized at physiological rates as indicated (mean ±SEM): G614C at 0.10±0.01 μmoles/min g brain (n=7) or 17.5±1.9 μmoles/ min kg fetus; and BOHB314C at 0.16±0.05 μmoles/min g (n=5) or 27.3±7.4 μmoles/ min kg.Based on fetal weight, glucose metabolism by brain apparently accounted for about 1/3 of basal glucose utilization in the fetus. On a molar basis BOHB314C was taken up at 1.47 times the rate of G614C. Both BOHB314C and G6 14C were converted to 14C02. The rate of BOHB314C conversion to 14CO2 was equal to its rate of consumption, and exceeded the conversion of glucose to CO2 because 45% of the G614C was incorporated into lactate‐14C. Accordingly, both substrates support oxidative metabolism by brain; and BOHB is a major potential alternate fuel which can replace glucose early in human development.
Hormonal Changes during Development in Turner's Syndrome
Authors: VLIET G. VAN 
Published: August 2010

ABSTRACTThe hormonal changes observed during infancy, childhood and adolescence in patients with Turner's syndrome are reviewed, with particular emphasis on gonadotrophins and GH. The relative roles of gonadal insufficiency, maturation of the CNS and disturbed body composition (i.e. obesity) are discussed with respect to the endocrine findings.
Auxological and Biochemical Assessment of Short Stature
Authors: HINDMARSH P.C. , BROOK C.G.D. 
Published: August 2010

ABSTRACTMeasurements of height and calculation of height velocity are highly accurate and sensitive to changes in a child's health. Definition of normality must be based on height velocity, and it is not acceptable to label a child as short and normal purely on the basis of a biochemical test unless this is substantiated with the demonstration of a normal height velocity. Response to therapy is dependent on the child's pretreatment growth rate and also on the amount of GH administered and the frequency of administration.
Somatonorm Post‐Marketing Surveillance Study (UK and Ireland, 1986‐1987): a Preliminary Report
Authors: WILD R. N. 
Published: August 2010

ABSTRACTA PMS study in the UK and Ireland recruited 581 children, mainly with GH deficiency, for treatment with Somatonorm and observation for 1 year; only 1 child proved totally non‐evaluable. The mean dose prescribed was 0.41 IU/kg/week, with 56% of children receiving below the recommended dose. Underdosing was reflected particularly by the low growth rates of pubertal children. Somatonorm was safe, with a low incidence of reported events, of which lipoatrophy (in 6 cases) was the most common. Antibody assays were seldom requested and always negative.
Clinical Experience with Genotropin in Growth Hormone Deficient Children
Authors: WILTON P. , GUNNARSSON R. 
Published: August 2010

ABSTRACTThe efficacy of Genotropin (recombinant somatropin, KabiVitrum AB, Sweden) was analysed in 194 children with GH deficiency, comprising a combined series of four multicentre trials. The linear height velocity increased from 3.3±1.4 to 9.3±2.6 cm/year in 149 prepubertal children with 12 months’data available. In 18 pubertal children the pretreatment height velocity was 4.0±1.2, and increased to 8.4±1.7 cm/year during 12 months of treatment. There was a positive correlation between the gain in height velocity and the weekly dose of Genotropin. Covariance analysis revealed significantly greater height velocity with 6‐7 injections/week compared to 2‐3 injections/week; corrections for chronological age, bone age, height SD score and dose were made. On average, a regimen of 6‐7 injections/week was 25% more effective than one of 2‐3 injections/week corresponding to an extra gain in height velocity of 1.8±0.6 cm/year. At 12 months, only 0.9% of the children had developed anti‐GH antibodies. Very few side‐effects have been reported from more than 1000 children on Genotropin.
Simplified Growth Hormone Therapy — First Clinical Experience with the KabiPen
Authors: ALBERTSSON‐WIKLAND K. 
Published: August 2010

ABSTRACTFor 30 years, GH deficient children have been treated with human GH. Earlier, therapy was given by intramuscular injections, but recently subcutaneous injections have been used. For the last few years, many children have been given daily injections, which have proved more effective. The form in which GH is supplied and administered entails taking an inconvenient hospital method into the daily family routine. The need to simplify the method of administration of GH has been fulfilled by a multidose vial for recombinant somatropin, developed to be used in an injection pen, the KabiPen. In the first clinical trial of 40 children, aged 2.5‐21 years, all the families found the KabiPen to be much more convenient, less time‐consuming, and easier when travelling; it also requires less space in the refrigerator and is easier for the child to handle. Most of the children found the KabiPen injections less painful, due to a finer and sharper needle and a smaller injection volume. Out of the 40 families, as many as 34 wanted to continue with the KabiPen after the 1‐month trial.
Growth and Sexual Maturation in Paediatric Patients Treated by Dialysis and Following Kidney Transplantation
Authors: DIEMEN‐STEENVOORDE R. VAN , DONCKERWOLCKE R. A. 
Published: August 2010

ABSTRACTLinear growth and sexual maturation were assessed in 48 children during dialysis treatment and in 68 children following renal transplantation. Height at the onset of haemodialysis treatment was more than 2 SD below the mean in 33% of prepubertal children. During dialysis treatment most children showed a progressive deterioration in SD score. The onset of puberty and sexual maturation was delayed but was in accordance with bone age. After transplantation 59% of prepubertal children had a normal height increment. Onset of puberty was recorded at a chronological age of 14.6 ± 1.9 years in boys and 13.3 ± 1.9 years in girls. The peak of the pubertal growth spurt was 6.6 ± 1.6 cm/year in boys and 6.5 ± 2.9 cm/year in girls. The duration of pubertal development in transplanted children was within normal limits. In transplanted girls menarche was achieved at a mean chronological age of 15.9 years and bone age of 12.9 years. Adult height was achieved at a mean age of 20.3 years in men and 18.7 years in women. Overall, one third of the children attained an adult height more than 2 SD below the mean. These data indicate that poor growth is achieved in most children on dialysis treatment; following transplantation normal growth may be restored. However, poor growth before kidney transplantation and the loss of growth potential during pubertal development have a great influence on adult height.
Disturbed Pubertal Growth in Girls after Acute Leukaemia: a Relative Growth Hormone Insufficiency with Late Presentation
Authors: MOËLL C. 
Published: August 2010

ABSTRACTLong‐term follow‐up of growth and development after acute lymphoblastic leukaemia (ALL) in childhood has previously been limited to the prepubertal period. This study describes pubertal growth, final height and the spontaneous secretion of GH in girls treated for ALL, including CNS irradiation with 24 Gy. Ten girls, treated earlier for ALL, experienced the menarche at a mean age of 12.2 years. This is significantly earlier than the mean for Swedish girls. Prepubertal growth was near normal after the end of therapy for leukaemia. Mean final height was ‐1.7 SD, which is 1.5 SD less than at onset and 1.0 SD less than 1 year after the end of treatment. Thirteen other girls had a blunted spontaneous secretion of GH, several years after treatment for ALL: there was no increase in GH secretion during puberty. These results suggest that girls who have been treated for ALL, including CNS irradiation, have a relative GH insufficiency. This insufficiency becomes obvious only when the girls cannot respond to the increased need for GH during the pubertal spurt.
Foetal supraventricular tachycardia treated with sotalol
Authors: Sonesson S‐E , Fouron J‐C , Wesslen‐Eriksson E , Jaeggi E , Winberg P 
Published: August 2010

Sonesson S‐E, Fouron J‐C, Wesslen‐Eriksson E, Jaeggi E, Winberg P. Foetal supraventricular tachycardia treated with sotalol. Acta Pædiatr 1998; 87: 584‐7. Stockholm. ISSN 0803‐5253This retrospective study (1991‐95) presents our experience with sotalol in the treatment of 14 foetuses with supraventricular tachycardia (SVT). SVT was diagnosed in a structurally normal heart at a gestational age of 24‐35 (median 28) weeks. In eight foetuses, hydrops was evident at presentation. In all patients pharmacological conversion with digoxin was tried before sotalol treatment was started. Sotalol was given orally to the mothers in a dose of 80–160 mg x2. Cardioversion was obtained in 10 foetuses. In seven of these patients re‐entry tachycardia and in five pre‐excitation could be documented after birth. In two foetuses not responding to sotalol a long RP tachycardia was demonstrated; even when using digoxin, sotalol, flecainide and/or propafenone in different combinations after birth complete suppression of the arrhythmia was not obtained. Two severely hydropic foetuses died 1 and 10 d, respectively, after starting with sotalol. The 12 surviving infants were doing well except for one infant, with a cerebral lesion probably related to the arrhythmia. These findings demonstrate that sotalol can be useful in the treatment of foetal SVT.
Interferon‐alpha in viral and bacterial gastroenteritis: a comparison with C‐reactive protein and interleukin‐6
Authors: Mangiarotti P , Moulin F , Palmer P , Ravilly S , Raymond J , Gendrel D 
Published: August 2010

Mangiarotti P, Moulin F, Palmer P, Ravilly S, Raymond J, Gendrel D. Interferon‐alpha in viral and bacterial gastroenteritis: a comparison with C‐reactive protein and interleukin‐6. Acta Pædiatr 1999; 88: 592‐4. Stockholm. ISSN 0803‐5253The aim of the study was to identify serum markers able to differentiate bacterial and viral origin in acute diarrhoea. Interferon‐alpha (INF‐α), C‐reactive protein (CRP) and interleukin‐6 were determined on admission in the sera of 119 children aged between 1 mo and 14 y who were hospitalized for rotavirus (n = 60) or bacterial diarrhoea (Salmonella spp. 39 cases, Shigella spp. 15 cases, Campylobacter jejuni 5 cases). CRP concentration was >10mg/l in 48.3% of children with viral gastroenteritis and 86.4% of children with bacterial gastroenteritis. IL6 concentration was >100pg/ml in 11.7% and 26.3% of cases, respectively. INF‐α was detected in 79.1% of children with rotavirus (sens 79%) and in 3.5% (spec 93%) with bacterial gastroenteritis. However the INF‐α assay takes 48 h and pathogens are often identified from stools before interferon results are available. We found that serum markers are not discriminating enough to differentiate between viral and bacterial gastroenteritis in emergency cases. □C‐reactive protein, interferon‐alpha, interleukin‐6, viral gastroenteritis, bacterial gastroenteritis
Clinically symptomatic central venous catheter‐related deep venous thrombosis in newborns
Authors: Salonvaara M , Riikonen P , Kekomäki R , Heinonen K 
Published: August 2010

Salonvaara M, Riikonen P, Kekomäki R, Heinonen K. Clinically symptomatic central venous catheter‐related deep venous thrombosis in newborns. Acta Pædiatr 1999; 88: 642‐6. Stockholm. ISSN 0803‐5253The objective of this study was to evaluate the incidence of clinically symptomatic central venous catheter (CVC)‐related deep venous thrombosis (DVT) in newborns and small infants and to try to identify clinical and genetic risk factors for catheter‐related DVT among children with thrombotic complications. CVC was inserted in 44 consecutive infants (age range 0‐90 d) during the period January 1990 to December 1995 in the neonatal intensive care unit (NICU) of Kuopio University Hospital in Kuopio. The symptoms of DVT were: syndrome of superior vena cava in 2, swelling at the CVC puncture site in 6 and repeated CVC obstructions in 2. The formation of DVT was verified by venography. Children with DVT (n= 10) had 26 (10‐365, in total 623) catheter days compared with 9 d (1‐155, in total 591) in patients without DVT (n = 26) (p < 0.005). The median (range) number of days from catheter insertion to diagnosis of DVT was 19 (7‐210). CVC had to be removed from 11 (25%) children due to various complications. There was no DVT‐related mortality. A positive family history with thromboembolic episodes at a young age was found in 3 of 10 families with a child suffering CVC‐related DVT. The levels of coagulation inhibitors were evaluated at the age of 9‐69 mo in all 10 (23%) children with CVC‐related DVT. We detected no deficiencies in protein S, protein C or antithrombin III. One child was heterozygous for the point mutation (R506Q) in the factor V gene known to cause activated protein C resistance (APCR). We conclude that newborns with CVC are at great risk of DVT and that the aetiology of DVT can rarely be identified via measurements of coagulation inhibitors. □Antithrombin III, central venous catheter, children, factor Vgene mutation, protein C, protein S, thrombosis