bluuebunny/crossref_metadata_2025_split huggingface dataset:
Natural History of a Giant Coronary Aneurysm With Spontaneous Dissection
Authors: Bouzas‐Mosquera Alberto , Vázquez‐González Nicolás , Álvarez‐García Nemesio , Soler Rafaela , Rodríguez Esther , Calviño‐Santos Ramón , Castro‐Beiras Alfonso 
Published: December 2009

AbstractPrimary spontaneous coronary artery dissection may appear in young women during the peripartum period or as a result of atherosclerosis. We present a patient with familial hypercholesterolemia who developed a giant aneurysm of the right coronary artery in the setting of atherosclerotic spontaneous coronary dissection over an 8 year period. This report illustrates the association between spontaneous coronary artery dissection and subsequent coronary aneurysm formation. Copyright © 2009 Wiley Periodicals, Inc.
Retracted: Relation of Atherosclerotic Cardiovascular Events to Progression of Aortic Stenosis in Older Men
Authors: Kamalesh Masoor , Ng Charlotte , Eckert George J. 
Published: December 2009

AbstractBackgroundRETRACTION: Publication of the following article is being retracted by the publisher due to erroneous publication. The authors were unable to obtain internal review board permission to publish the work and requested withdrawal after acceptance of: "Relation of Atherosclerotic Cardiovascular Events to Progression of Aortic Stenosis in Older Men" by Masoor Kamalesh, Charlotte Ng, and George Eckert. This article published on EarlyView on December 14, 2009 (DOI: 10.1002/clc.20541.

Aortic stenosis (AS) is now considered to be an active disease like atherosclerosis. However, therapies such as statins have not shown benefit in AS patients when studied prospectively.HypothesisWe tested the hypothesis that if AS was indeed similar to atherosclerosis, then subjects with progressive AS should have a higher atherosclerosis related event rate than those without progression of AS.MethodsTwo readers independently measured the aortic valve area using a continuity equation in 164 consecutive subjects with AS between January 1997 through March 2005, referred to our laboratory for serial echocardiograms for AS. Subjects with no progression of AS were compared to subjects with progression of reduction in valve area with regards to baseline demographics, occurrence of all myocardial infarctions, stroke, unstable angina requiring hospitalization, and coronary revascularization. A χ2 test were use to compare the groups for differences in endpoints.ResultsThe study cohort included 164 males age 70 ± 9 years. Age, low‐density lipoprotein level, hypertension, or diabetes status were similar among the 2 groups, while the no progression group had more smokers and fewer patients on statins (P<.05). Aortic stenosis progressed in 99 subjects (60% of total) during mean follow‐up of 2.5 years. A total of 28 patients had cardiovascular events (9 myocardial infarctions, 1 stroke, 20 coronary revascularizations, 5 unstable angina requiring hospitalization). Of these, 8 (12%) occurred in the no progression group and 20 (20%) occurred in the progression group (P = .16).ConclusionsProgressive AS is not paralleled with increased occurrence of atherosclerotic cardiovascular events despite described similarities in risk factors for AS and atherosclerosis. Copyright © 2010 Wiley Periodicals, Inc.
Three Year Follow‐up of the Sirolimus‐Eluting Stent and the Paclitaxel‐eluting Stent in Daily Practice
Authors: Gao Zhan , Yang Yuejin , Xu Bo , Chen Jilin , Qiao Shubin , Li Jianjun , Wu Yongjian , Qin Xuewen , Yuan Jinqing , Gao Runlin 
Published: December 2009

AbstractBackgroundAlthough the efficacy and safety of Cypher and Taxus stents for particular patients and lesions had been proven by random clinical trials, their long‐term comparative effect for unselected Chinese patients in daily practice is still unknown.MethodsFrom April 2004 to April 2005, 682 consecutive patients who were implanted with a Cypher stent (C group: n = 456, 57.3 ± 10.8 years old) or a Taxus stent (T group: n = 226, 57.2 ± 10.2 years old) in our center were analyzed. A mean 3 year clinical and 7 month angiographic follow‐up was performed.ResultsThere was no difference in major adverse cardiac events (MACE) rates in the C and T groups (16.4% vs 21.7%; P = .113), and there was also no difference in cardiac death or myocardial infarction (MI) rates in both groups (2.6% vs 1.8%; P = .598, 3.3% vs 3.5%; P = .826 respectively), but target vessel revascularization (TVR) was higher in the T group (10.5% vs 16.4%; P = .036). There was no difference in total stent thrombosis or its components in both groups (total: 3.9% vs 3.5%; P = 1.000, early: 0.2% vs 0.9%; P = .256, late: 0.7% vs 1.3%; P = .404, and very late: 3.1% vs 1.3%; P = .201 respectively). A 7 month angiographic follow‐up indicated that both in‐stent and in‐segment restenosis rate were significantly lower in the C group (11.1% vs 21.0%; P = .034 and 12.2% vs 24.0%; P = .018), and in‐stent and in‐segment late loss were significantly smaller in the C group (0.18 ± 0.08 mm vs 0.53 ± 0.38 mm; P = .000 and 0.17 ± 0.09 mm vs 0.38 ± 0.19 mm; P = .000).ConclusionResults from this 3 year follow‐up, single‐center study showed almost the same effective and safe profile for both Cypher and Taxus stents, except for a better reducing restenosis effect in the Cypher stent. Copyright © 2009 Wiley Periodicals, Inc.
A randomized, controlled, double‐blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL)
Authors: Ladas Elena J. , Kroll David J. , Oberlies Nicholas H. , Cheng Bin , Ndao Deborah H. , Rheingold Susan R. , Kelly Kara M. 
Published: December 2009

AbstractBACKGROUND:Despite limited preclinical and clinical investigations, milk thistle (MT) is often used for the treatment of chemotherapy‐associated hepatotoxicity. Limited treatment options exist for chemotherapy‐related hepatoxicity. Given the wide use of MT, the authors investigated MT in both the laboratory and a clinical setting.METHODS:In a double‐blind study, children with acute lymphoblastic leukemia (ALL) and hepatic toxicity were randomized to MT or placebo orally for 28 days. Liver function tests were evaluated during the study period. To assess MT in vitro, the authors evaluated supratherapeutic concentrations in an ALL cell line.RESULTS:Fifty children were enrolled. No significant differences in frequency of side effects, incidence and severity of toxicities, or infections were observed between groups. There were no significant changes in mean amino alanine transferase (ALT), aspartate amino transferase (AST), or total bilirubin (TB) at Day 28. At Day 56, the MT group had a significantly lower AST (P = .05) and a trend toward a significantly lower ALT (P = .07). Although not significantly different, chemotherapy doses were reduced in 61% of the MT group compared with 72% of the placebo group. In vitro experiments revealed no antagonistic interactions between MT and vincristine or L‐asparaginase in CCRF‐CEM cells. A modest synergistic effect with vincristine was observed.CONCLUSIONS:In children with ALL and liver toxicity, MT was associated with a trend toward significant reductions in liver toxicity. MT did not antagonize the effects of chemotherapy agents used for the treatment of ALL. Future study is needed to determine the most effective dose and duration of MT and its effect on hepatotoxicity and leukemia‐free survival. Cancer 2010. © 2009 American Cancer Society
Correlation between ZAP‐70, phospho‐ZAP‐70, and phospho‐Syk expression in leukemic cells from patients with CLL
Authors: Kaplan David , Meyerson Howard J. , Li Xiaofeng , Drasny Carly , Liu Fangfang , Costaldi Mark , Barr Paul , Lazarus Hillard M. 
Published: December 2009

AbstractFor patients with chronic lymphocytic leukemia (CLL), expression of ZAP‐70 in the leukemic cells is an indicator of poor prognosis. However, the mechanism that accounts for this effect is not known. ZAP‐70 expression has previously been associated with increased B cell antigen receptor signaling upon surface immunoglobulin ligation in vitro as shown by ZAP‐70 and Syk phosphorylation. This finding has led to the suggestion that a more aggressive clinical course is correlated with B cell antigen receptor signaling. Using high resolution immunophenotyping to analyze CLL cells ex vivo (without stimulation in vitro), we have demonstrated CLL cells from all patients express some ZAP‐70 and that increased expression of ZAP‐70 is correlated with decreased levels of phosphorylated ZAP‐70 and phosphorylated Syk measured directly ex vivo. Conversely, high levels of phosphorylated ZAP‐70 and phosphorylated Syk are found only in samples with low levels of ZAP‐70 expression, and Syk and ZAP‐70 phosphorylation appear to be mostly independent of each other. Additionally, Syk phosphorylation is directly correlated with levels of p21cip1, a cell cycle inhibitor and a p53 target. Together these findings suggest that lower levels of p21cip1 and/or a defect in p53 activity may account in part for the more aggressive disease course in patients with high levels of ZAP‐70 rather than enhanced B cell antigen receptor signaling as has been previously hypothesized. © 2009 Clinical Cytometry Society
Atypical glandular cells (AGC): ThinPrep Imaging System (TIS), manual screening (MS), and correlation with Hybrid Capture 2 (HC2) HPV DNA testing
Authors: Sireci Anthony N. , Crapanzano John P. , Mansukhani Mahesh , Wright Thomas , Babiac Anamaria , Erroll Maria , Vazquez Madeline , Saqi Anjali 
Published: December 2009

AbstractObjectiveThe aim of the study was to determine if the ThinPrep Imaging System (T1S) improves the positive predictive value (PPV) of atypical glandular cell (AGC) diagnosis for identifying HPV‐related squamous and/or glandular lesions over manual screening (MS), and if human papilloma virus (HPV)‐DNA testing improves the diagnostic yield.Materials and Methods85 ThinPrep cervical cytology specimens with a diagnosis of AGC by TIS (n = 51) and MS (n = 34) were retrieved. The diagnoses were correlated with corresponding histologic follow‐up and high risk (HR)‐HPV testing results.ResultsThe PPV of AGC by TIS and MS for HPV‐related squamous lesions were similar. In the MS group, more cases of glandular pathology were identified, however only three represented adenocarcinoma in‐situ (AIS), and the remaining ten were endometrial carcinomas (EMCA).ConclusionsTIS and MS are comparable in the detection of AGC representing squamous histology and the addition of HPV DNA testing does not differentially improve performance. Although the MS group harbored more glandular pathology, the differences in the detection of AIS were not statistically significant. Diagn. Cytopathol. 2010;38:705–709. © 2009 Wiley‐Liss, Inc.
Can mobile units improve the strategies for cervical cancer prevention?
Authors: Mauad Edmundo Carvalho , Nicolau Sérgio Mancini , Gomes Uilho A. , da Costa Vieira René Aloísio , de Castro Mattos Jacó Saraiva , Longatto‐Filho Adhemar , Baracat Edmund C. 
Published: December 2009

AbstractCervical cancer is a serious public health problem in women in developing countries because of absence or ineffectiveness of screening programs. Several biases to access medical care and inequity of public health system in a continental country like Brazil limit the implementation of adequate programs to appropriately prevent the cervical cancer. Therefore, the aim of this study was to evaluate the results of applying the mobile unit (MU) for cervical cancer screening. From May 2003 to May 2004, a cervical cancer screening was offered to women aged 20–69 years, residing in 19 municipal districts of the Barretos county region, in São Paulo. Out of the 9,560 examination available, 2,964 (31%) women underwent screening. The medium distance traveled by the MU was 45 km. The medium time spent by women in the MU for completion of the questionnaire and doing the exam was 20 minutes. It was observed that 17.0% of women screened had never had the test or had not had it repeated within the last 3 years. The negative response was more common among women aged 20 to 29 years and 60 to 69 years and among women with less schooling and lower socio‐economic income (P < 0.05). MU can significantly overcome the chronic deficiency of public health system accessibility offering opportunity to these women to participate in screening programs. Diagn. Cytopathol. 2010;38:727–730. © 2009 Wiley‐Liss, Inc.
The prevalence of abnormal cervical cytology in women with infertility
Authors: AbdullGaffar Badr , Kamal Mohamed O. , Hasoub Ahmed 
Published: December 2009

AbstractThe aim of this study was to compare the frequency of abnormal cervical cytology in women with infertility problems with that of fertile women by using ThinPrep® liquid‐based Pap Tests™. A retrospective case–control study for over 2 years was conducted. The cases included all women with infertility problems who had Pap tests during their infertility treatment period. The cases were further subdivided into primary and secondary infertility groups. The control group included all women without infertility problems who had routine Pap tests in the same period. The age and demographic features were adjusted and matched for both groups. Statistical analysis included chi‐square test and Fischer exact test. The infertility group (n = 490) showed significantly (P < 0.05) more abnormal cervical squamous epithelial abnormalities (48 positive cases, 9.8%) than the controls (n = 7,150, 216 positive cases, 3%). Women with secondary infertility had more epithelial abnormalities and more high‐grade lesions than women with primary infertility. Women with infertility had statistically significant higher frequency of squamous intraepithelial lesions than women without infertility problems of similar age and demographic background. The data suggest that women with infertility might benefit from more frequent cervical cytology screening. Diagn. Cytopathol. 2010;38:791–794. © 2009 Wiley‐Liss, Inc.
Metastatic signet ring cell carcinoma presenting as a thyroid nodule: Report of a case with fine‐needle aspiration cytology
Authors: Wheeler Yurong Y. , Marie Stoll Lisa , Sheth Shiela , Kay Li Qing 
Published: December 2009

AbstractMetastatic carcinomas to the thyroid are quite rare in daily cytology practice. However, when present they may produce a diagnostic dilemma, particularly when they share some morphologic similarities with primary thyroid lesions and when occurring in patients with occult malignant history. Herein, we report a case of metastatic gastric signet ring cell carcinoma to the thyroid. Our patient presented with an isolated right thyroid nodule, which was clinically considered to be a primary thyroid neoplasm. Fine‐needle aspiration (FNA) cytology of the nodule revealed a cellular specimen with cohesive fragments and scattered individual neoplastic cells. The neoplastic cells had enlarged nuclei, fine chromatin, and inconspicuous nucleoli. Nuclear crowding, molding, and grooving were prominent. Intranuclear inclusion‐like clearance was identified. Some tumor cells also had eccentric nuclei, creating a signet ring cell appearance. The colloid was scant. These cytological features may be seen in cases of papillary thyroid carcinoma or signet ring cell follicular adenoma; however, the presence of the signet ring cells is unusual in primary thyroid lesions and raises the possibility of a metastatic lesion to the thyroid. In our case, the tumor cells were positive for AE1/AE3, mucicarmine, and periodic acid‐Schiff, but negative for thyroglobulin and thyroid transcription factor‐1. The patient was also found to have a 3.7‐cm mass in the distal esophagus/proximal stomach. Biopsy of this mass showed an invasive signet ring cell carcinoma. The purpose of our study is to discuss the cytological features and the differential diagnosis of this unusual thyroid FNA case. Diagn. Cytopathol. 2010;38:597–602. 2009 Wiley‐Liss, Inc.
Sarcomatoid collecting duct carcinoma of kidney diagnosed with urine and renal pelvic lavage cytology
Authors: Mimura Akihiro , Sakuma Takahiko , Furuta Michiko , Tanigawa Naoto , Takamizu Ryuichi , Kawano Kiyoshi 
Published: December 2009

AbstractA case of sarcomatoid collecting duct carcinoma (CDC) of kidney is presented, in which the diagnosis was made cytologically with voided urine and renal pelvis lavage. Cytology of hemorrhagic voided urine revealed highly atypical adenocarcinoma cells with reminiscent ductal structure, which suggested CDC as the most likely diagnosis. Computed tomography and magnetic resonance imaging demonstrated a left renal tumor, and selective lavage of left renal pelvis yielded spindle‐shaped, highly atypical cells that indicated sarcomatoid carcinoma. The diagnosis of renal cancer with urine cytology is challenging because of small number of tumor cells in the urine, which are often associated with degeneration. As the urinary cytologic findings of sarcomatoid CDC have not been reported, the characteristic cytologic findings of sarcomatoid CDC are described in detail, and the differential diagnoses with diagnostic pitfalls were discussed. Diagn. Cytopathol. 2010;38:603–606. 2009 Wiley‐Liss, Inc.
Thyroid follicular neoplasm: Analysis by fine needle aspiration cytology, frozen section, and histopathology
Authors: Liu Feng‐Hsuan , Liou Miaw‐Jene , Hsueh Chuen , Chao Tzu‐Chieh , Lin Jen‐Der 
Published: December 2009

AbstractWe performed a retrospective analysis of follicular neoplasm data obtained from frozen section examinations of thyroid nodules. A total of 5,660 patients underwent preoperative neck ultrasonography and fine‐needle aspiration cytology (FNAC), surgical treatment, and follow‐up at a medical institute. Patients with papillary thyroid microcarcinoma were excluded from this study. In 971 cases, frozen section examination was performed during the surgical treatment of follicular neoplasm that was diagnosed via FNAC. Thyroid malignancies were histologically confirmed in 25.1% of cases (244/971). Among the patients with papillary thyroid carcinoma, 45 were diagnosed with the follicular variant of papillary thyroid carcinomas (27.4%). The diagnostic sensitivity of frozen section for the nonfollicular variant of papillary thyroid carcinoma was better than that for the follicular variant of papillary thyroid carcinoma (89.1% versus 78.9%; P = 0.1023). For 12 cases the diagnosis was atypical follicular adenomas. The diagnostic accuracy of frozen section in cases of follicular neoplasm was 76.9% with a sensitivity of 84.8% and a specificity of 98.9%. In conclusion, our analysis revealed high rates of accuracy when using frozen tissue sections for early diagnosis and treatment of follicular neoplasm; thus, an early decision to extent of surgery prevents a risky follow‐up surgery. Diagn. Cytopathol. 2010;38:801‐805. © 2009 Wiley‐Liss, Inc.
Visual stimulation enhances auditory processing in 3‐month‐old infants and adults
Authors: Hyde Daniel C. , Jones Blake L. , Porter Chris L. , Flom Ross 
Published: December 2009

AbstractBehavioral work demonstrates human infants are sensitive to a host of intersensory properties and this sensitivity promotes early learning and memory. However, little is known regarding the neural basis of this ability in infants. Using event‐related potentials (ERPs) with infants and adults, we show that during passive viewing auditory evoked brain responses are increased with the presence of simultaneous visual stimulation. Results converge with previous adult neuroimaging studies, single‐cell recordings in nonhuman animals, and behavioral studies with human infants to provide evidence for an elevated status of multisensory stimulation in infancy. Furthermore, these results may provide a neural marker of multisensory audio‐visual processing in infants that can be used to test developmental theories of how information is integrated across the senses to form a unitary perception of the world. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 52:181–189, 2010
The effect of taste familiarity on intake and taste reactivity in infant rats
Authors: Diaz‐Cenzano Elena , Chotro M. Gabriela 
Published: December 2009

AbstractWith infant rats, unlike with adults, increased intake of a taste after mere exposure to this stimulus is not consistently found; this has sometimes been interpreted as a failure by the immature subject to recognize tastes as familiar. We studied the effect of preexposure to a tastant, measuring taste reactivity and intake in 14‐day‐old rats. Familiarity increased hedonic response to sucrose, but also increased aversive response to quinine and ethanol. With the sucrose‐quinine compound, familiarity increased both the hedonic and the aversive reaction to the stimulus. In no case was a differential reactivity to water observed. Significant increased intake after familiarization was only found with quinine or the sucrose‐quinine compound. Results indicate that in infant rats, and with the present parameters, taste familiarity enhances responsiveness to these stimuli, an effect not always accompanied by detectable changes in intake. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 52:109–120, 2010
Snowbrush (Ceanothus velutinus Dougl) effects on nitrogen availability in soils and solutions from a Sierran ecosystem
Authors: Stein C. M. , Johnson D. W. , Miller W. W. , Powers R. F. , Young D. A. , Glass D. W. 
Published: December 2009

AbstractThe presence of nitrogen (N) fixing vegetation can have significant deleterious effects on water quality and also soil leaching. This study investigates the effects of snowbrush (Ceanothus velutinus Dougl.), a common post‐disturbance N fixer in the western United States, on water quality and soil leaching. We compared mineral N concentrations in soil solution, runoff, O horizon leachates and resin lysimeters in adjacent snowbrush and Jeffrey pine (Pinus jeffreyii Grev. & Balf) stands in one site in the eastern Sierra Nevada Mountains in Nevada. Soil solutions from snowbrush had slightly but not significantly greater NO3− concentrations than those from Jeffrey pine. Leaching rates of NO3− and NH4+ measured by resin lysimeters were lower in snowbrush than in Jeffrey pine, and leaching rates in mineral soil (15 cm) were not significantly different. Nitrate and NH4+ concentrations in runoff were greater in the snowbrush than Jeffrey pine, and ancillary field column studies confirmed that snowbrush litter was the primary source of this elevated mineral N. Cutting, followed by mastication and herbicide treatments had no effect on mineral N leaching in a snowbrush stand growing on a recently burned (1994) site in the eastern Sierra Nevada Mountains of California. We conclude from this and previous studies that snowbrush, unlike some other post‐disturbance N‐fixing species, has minimal and inconsistent effects on water quality in the eastern Sierra Nevada Mountains. Copyright © 2009 John Wiley & Sons, Ltd.
Water Dissociation and Dioxygen Binding in Phenylalanine Hydroxylase
Authors: Olsson Elaine , Martinez Aurora , Teigen Knut , Jensen Vidar R. 
Published: December 2009

AbstractPhenylalanine hydroxylase (PAH) catalyzes the hydroxylation of L‐phenylalanine to L‐tyrosine and is dependent on the contribution of electrons from the reduced cofactor tetrahydrobiopterin (BH4). Whereas three ligating water molecules are bound to the central iron atom in the existing crystal structures of binary complexes of the catalytic domain of both the inactive, PAH–FeIII–BH2, and active, PAH–FeII–BH4, forms of the human enzyme, previous spectroscopic studies show that the water molecules dissociate prior to the onset of the catalytic reaction. In the present study, starting from a cluster model of the active FeII center of PAH, three successive water ligand dissociations followed by dioxygen coordination have been investigated by using density functional theory. The calculations show that the formation of the active, water‐free O2 complex from the water‐ligated complex of the PAH–FeII–BH4 crystal structure is remarkably facile (ΔG = 1.5 kcal/mol). Moreover, the initial water dissociation is accompanied by entrance of the cofactor into the first coordination sphere of iron.