bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study
Authors: Ota Vanessa Kiyomi , Oliveira Adrielle Martins , Bugiga Amanda Victória Gomes , Conceição Helena B. , Galante Pedro Alexandre Favoretto , Asprino Paula Fontes , Schäfer Julia Luiza , Hoffmann Mauricio Scopel , Bressan Rodrigo , Brietzke Elisa , Manfro Gisele Gus , Grassi-Oliveira Rodrigo , Gadelha Ary , Rohde Luis Augusto , Miguel Euripedes Constantino , Pan Pedro Mario , Santoro Marcos Leite , Salum Giovanni Abrahao , Carvalho Carolina Muniz , Belangero Sintia Iole 
Published: February 2025

IntroductionWhile the influence of both genetic and environmental factors on the development of psychiatric symptoms is well-recognized, the precise nature of their interaction throughout development remains a subject of ongoing debate. This study investigated the association between the expression of 78 candidate genes, previously associated with psychiatric phenotypes, in peripheral blood and both adversity and psychopathology in a sample of 298 young individuals assessed at two time points from the Brazilian High Risk Cohort Study for Mental Conditions (BHRCS).MethodsPsychopathology was assessed using the Child Behavior Checklist (CBCL), considering the total CBCL, p-factor (i.e. general factor of psychopathology), and internalizing and externalizing symptoms as clinical variables. The life adversities considered in this study includes four composite variables: child maltreatment, stressful life events, threat and deprivation. Gene expression was measured using next-generation sequencing for target genes and differential gene expression was analyzed with the DESeq2 package.ResultsMixed models revealed six genes associated with internalizing symptoms: NR3C1, HSPBP1, SIN3A, SMAD4, and CRLF3 genes exhibited a negative correlation with these symptoms, while FAR1 gene showed a positive correlation. Additionally, we also found a negative association between USP38 gene expression and externalizing symptoms. Finally, DENND11 and PRRC1 genes were negatively associated with deprivation, a latent factor characterized by neglect, parental absence, and measures of material forms of deprivation. No mediation or moderation effect was observed of gene expression on the association between life adversities and psychiatric symptoms, meaning that they might influence distinct pathways.DiscussionAmong these nine genes, NR3C1, which encodes a glucocorticoid receptor, is by far the most investigated, being associated with depressive symptoms, early life adversity, and stress. While further research is needed to fully understand the complex relationship between gene expression, life adversities, and psychopathology, our findings provide valuable insights into the molecular mechanisms underlying mental disorders.
Assessment of obstructive sleep apnea rate and associated factors among Lebanese adults: a cross-sectional study
Authors: Kaddoura Tala , Hodroj Mohamad , Chmeis Bilal , Rammal Fatima , Malhab Sandrella Bou , Mansour Sara , Akour Amal , El Khatib Sami , Hosseini Basile , Hallit Souheil , Malaeb Diana , Hosseini Hassan 
Published: February 2025

ObjectivesTo estimate the rate of obstructive sleep apnea (OSA) and associated factors among Lebanese adults.MethodsA cross-sectional study was conducted in February–April 2022; 1,202 Lebanese adults were enrolled. The sample was collected among several Lebanese governorates through an anonymous online self-reported questionnaire. The STOP-BANG questionnaire was used as a screening tool to estimate the OSA risk. “Low OSA risk” is established with 0–2 positive answers, “Intermediate OSA risk” is established by 3–4 positive answers while “High OSA risk” is established by 5–8 positive answers.ResultsThis study showed that 743 (62.4%) of the sample had low risk for OSA, 357 (30.0%) had moderate, and 90 (7.6%) had high risk for OSA. Older age (aOR = 1.05) and having hypertension (aOR = 7.80) were associated with higher odds of moderate OSA. Female sex (aOR = 0.04) was significantly associated with lower odds of moderate OSA compared to males. Older age (OR = 1.17), higher BMI (OR = 1.14), hypertension (OR = 18.55), and having severe COVID-19 infection compared to mild (OR = 4.30) were significantly associated with higher odds of high OSA, whereas female sex (OR = 0.002) and being married compared to single (aOR = 0.23) were associated with lower odds of high OSA.ConclusionThis study showed that most Lebanese adults have low risk for OSA. It also confirmed that sex, age, obesity, hypertension, and severe COVID-19 were associated with high OSA risk. These associated factors call for future research exploring the causes including the potential effect of social, economic, and political instability, local customs, and environmental factors. Moreover, future health campaigns should be assigned to increase awareness among Lebanese population regarding the prevention of OSA through lifestyle modifications.
Exploring the impact of vitamin D-related genetic variants on muscular fitness changes in middle-aged and older adults in Kosovo
Authors: Krasniqi Ermira , Boshnjaku Arben , Wagner Karl-Heinz , Wessner Barbara 
Published: February 2025

IntroductionAge-related decline in muscle strength and performance significantly impact morbidity and mortality. Various factors including genetics have been investigated to better understand this decline. This study aimed to investigate longitudinal changes in physical performance and strength and their association with genetic variants in genes involved in the vitamin D pathway.MethodsThis longitudinal study was conducted in the Prishtina region, Kosovo, with community-dwelling adults over 40 years of age. Genomic DNA was extracted from saliva samples to assess single nucleotide polymorphisms in the vitamin D receptor (VDR) gene (rs7975232, rs2228570, rs731236, also referred to as ApaI, FokI, and TaqI, respectively) and the vitamin D binding protein (GC) gene (rs4588, rs2282679). Physical performance was assessed by isometric handgrip strength, 30-s chair stand, timed up and go and 6-min walk test. Vitamin D levels were assessed from blood samples only at follow-up.ResultsA total of 138 participants (65.1 ± 9.0 years, 52.2% female) were included. Over a 2.7-year period, significant declines in the 30-s chair stand test (p &lt; 0.001) and timed up and go performance (p &lt; 0.001) were observed, whereas BMI increased. Only female participants experienced a decrease in handgrip strength (p &lt; 0.001). Genotyping showed significant associations of the ApaI variant with changes in BMI and handgrip strength. Participants with the minor CC genotype showed a greater increase in BMI and a greater decrease in absolute and relative handgrip strength. No significant interactions were observed for FokI and TaqI in the VDR gene, or rs4588 and rs2282679 in the GC gene. Vitamin D deficiency (&lt;50 nmol/L) was prevalent in 47.5% of participants, with significant differences in 25(OH)D levels observed between genotypes of the GC gene (rs4588, p = 0.039; rs2282679, p = 0.036).ConclusionPhysical fitness declined significantly over time, with female participants experiencing a greater decline in handgrip strength. The ApaI variant in the VDR gene was associated with changes in muscle strength, while variants in the GC gene were associated with vitamin D levels. These findings suggest that genetic factors related to the vitamin D pathway may contribute to the age-related decline in muscle strength. Therefore, genetic predisposition should be considered when developing individual interventions for healthy aging.
Symmetry Properties and Their Application to Hilfer Fractional Systems
Authors: Sikora Beata 
Published: February 2025

The paper investigates semilinear Hilfer fractional systems. A symmetric fractional derivative and its properties are discussed. A symmetrized model for these systems is proposed and examined. A bounded nonlinear function f is applied, depending on the time as well as on the state. The Laplace transformation is used to derive the solution formula for the systems under consideration. The primary contribution of the paper is the formulation and proof of controllability criteria for symmetrized Hilfer systems. To deepen the understanding of the dynamics of such systems, the concept of reflection symmetries is introduced with a detailed analysis of their essential features, including projection functions and a reflection operator. Furthermore, a decomposition of the symmetric Hilfer fractional derivative is presented, utilizing the projection function and reflection operator. This decomposition not only provides a controllability condition for symmetrized Hilfer systems but also clarifies the relationship between the system’s trajectory across subintervals. Two illustrative examples are presented to demonstrate the computational and practical significance of the theoretical results.
The Design, Simulation, and Construction of an O2, C3H8, and CO2 Gas Detection System Based on the Electrical Response of MgSb2O6 Oxide
Authors: Guillen Bonilla José Trinidad , Jiménez Rodríguez Maricela , Bonilla Héctor Guillen , Bonilla Alex Guillen , Padilla Emilio Huízar , Morales María Eugenia Sánchez , Flores Jiménez Ariadna Berenice , Gutiérrez Juan Carlos Estrada 
Published: February 2025

In this paper, the prototype of a gas detector based on the electrical response of MgSb2O6 oxide at 400 °C and with a concentration of 560 ppm was designed, simulated, and fabricated. This design considers a PIC18F4550 microcontroller and a response time of 3 s for the sensor. It is worth noting that the response system can be reduced in concordance with the mathematical model of the sensor’s electrical response. The proposed device is capable of detecting one to three gases: O2, C3H8, and CO2. The configuration is achieved through three switches. In programming the prototype, factors such as the gas sensor signals, device configuration, corrective gas signals, and indicator signals were carefully considered. The characteristic of the gas detector is an operational temperature of 400 °C, which is ideal for industrial processing. This can be configured to detect a single gas or all three of them O2,C3H8,and CO2. Each gas type has its corresponding corrective signal and an indicator-led diode. The operation concentration is 560 ppm, the device is scalable, and its programming can be extended to cover industrial networks.
Influence of underlayer on development of chemically amplified photoresist film in tetramethylammonium hydroxide (TMAH) aqueous developer
Authors: Wang Jiahao , KOZAWA Takahiro 
Published: February 2025

Abstract
The interactions between the underlayer and photoresist significantly affect the dissolution behavior and patterns formed in the photoresist during development. Therefore, it is important to analyze the dissolution behavior of a photoresist with a underlayer. In this study, the dissolution behavior of poly (4-hydroxystyrene) films partially protected with tert-butoxycarbonyl groups and containing a photoacid generator (PAG) and photodecomposable quencher (PDQ) in a tetramethylammonium hydroxide aqueous solution is investigated using a quartz crystal microbalance. Triphenylsulfonium nonaflate and triphenylsulfonium salicylate are used as the PAG and PDQ, respectively. The underlayer has a complex influence on the dissolution behavior of the photoresist films during development. In particular, the underlayer significantly affects the formation of the transient swelling layer and dissolution kinetics at an exposure dose close to the photoresist sensitivity, namely, at the critical exposure dose for solubilizing the photoresist films.
TINJAUAN ILMIAH MENGENAI PERBANDINGAN EFEKTIVITAS DAN KEAMANAN ERDOSTEIN, KARBOSISTEIN, DAN N-ASETILSISTEIN PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK EKSASERBASI AKUT
Authors: Walter Bryan , Wiliam Wiliam , Citraningtyas Theresia 
Published: February 2025

Abstrak
Penyakit Paru Obstruktif Kronik (PPOK) eksaserbasi akut merupakan perburukan PPOK stabil/gejala respiratori. Global Initiative for Chronic Obstructive Lung Disease (GOLD) tahun 2020 menunjukkan erdostein, karbosistein, dan n-asetilsistein dapat mengurangi resiko eksaserbasi akut pada PPOK. Tujuan penulisan adalah untuk mengetahui dan membandingkan efektivitas dan keamanan erdostein, karbosistein, dan n-asetilsistein pada PPOK eksaserbasi akut. Tinjauan ilmiah berupa kajian pustaka dengan pencarian data menggunakan buku, jurnal dan situs web. Enam belas artikel didapat dengan hasil erdostein, karbosistein, dan n-asetilsistein menurunkan risiko eksaserbasi akut PPOK. Hasil efektivitas terbaik bergantung dari dosis obat dan lama pemakaian. Pengurangan risiko eksaserbasi terbaik pada erdostein oral, dosis 900 mg setiap hari selama 10 hari (39,1 %), Karbosistein 1500 mg sehari selama 6-12 bulan (p < 0,00001) dan n-asetilsistein 1.200 mg/hari selama 3 bulan (p<0,05). Erdostein ditoleransi baik dan tidak ada efek samping terkait pengobatan. Frekuensi efek samping infeksi saluran pernapasan tidak terdeteksi pada erdostein, namun untuk karbosistein ditemukan sebesar 0,56% dan NAC 10,85%. Dua pasien keluar dari penelitian karena gangguan gastrointestinal terkait efek samping karbosistein. Kesimpulan tinjauan ilmiah ini adalah penggunaan erdostein 900 mg/hari selama 10 hari memiliki efektivitas terbaik dalam menurunkan eksaserbasi PPOK, selanjutnya karbosistein 1500 mg
Kata kunci : eksaserbasi akut, erdostein, karbosistein, n-asetilsistein, Penyakit Paru Obstruktif Kronik (PPOK)
Currículo e Álgebra nos Anos Iniciais do Ensino Fundamental
Authors: Luna Ana Virginia de Almeida , Silva João Alberto da , Alencar Edvonete Souza de 
Published: February 2025

Este dossiê é uma proposta do GT01, que versa sobre Matemática na Educação Infantil e anos iniciais do Ensino Fundamental, da Sociedade Brasileira de Educação Matemática - SBEM. Este grupo reúne os pesquisadores brasileiros que têm se dedicado à Educação Matemática para crianças. A partir de 2017, a Base Nacional Comum Curricular consolida a Álgebra como unidade temática da Matemática a ser desenvolvida nos anos iniciais. Trata-se de uma relativa inovação frente aos Parâmetros Curriculares Nacionais, que eram até então vigentes. Esta reforma curricular provoca a discussão sobre o que é e como seria o ensino de Álgebra para crianças. O GT01 tem aprofundado as discussões e avançado em estudos para compreender a Álgebra nos anos iniciais, com a intenção de subsidiar as práticas de ensino e aprendizagem. Neste dossiê propomos uma discussão a respeito dos currículos oficiais para ensino de Álgebra nos anos iniciais do Ensino Fundamental. Nosso objetivo é apresentar estudos com análises de currículos nos âmbitos municipais e estaduais das diferentes regiões do país e de outros países, no que se refere à Álgebra. A expectativa foi a publicação de artigos que contemplassem pesquisas documentais sobre os currículos oficiais, incluindo, com especial relevância, materiais complementares e orientações pedagógicas que estes documentos apresentam.
Human resource management in a district health system in the public health sector
Authors: Mathews Verona E. 
Published: February 2025

Orientation: There is a misalignment between the strategic goals of the public health sector, which include strengthening health systems to produce desired health outcomes, and the human resource management of the human resources for health.Research purpose: This study aimed to describe the extent and identify the factors influencing the human resource management in achieving the strategic objectives of the public health sector.Motivation for the study: Managers in the public health sector can develop interventions and effective procedures to improve alignment in the human resource management of the human resources for health to improve health outcomes.Research approach/design and method: A qualitative descriptive study design with an interpretivist approach was utlised to conduct the study. A document review and sixteen face-to-face interviews were conducted, eight human resource (HR) practitioners and eight line managers purposively selected from an urban and rural district.Main findings: The public health sector provides a unique context that requires different considerations for human resource management. Human resource managers and line managers do not only have different backgrounds and orientations but they also function in different contexts (administrative vs. clinical) in the public health sector. The factors influencing effective human resource management are as follows: the lack of capacity to implement key HR strategies in the public health sector, competing priorities and the absence of clear roles in performing human resource practices.Practical/managerial implications: There is a need to foster a partnership approach between the HR manager and line manager to provide effective human resources management as it is complex and fractured, particularly during change and decentralisation.Contribution/value-add: This article addresses the research gap on human resource management in the public health sector shifting focus from individual practices to a systems thinking approach in strengthening human resource management. It also makes a theoretical contribution by adding context to human resource management as a key requirement for implementation decision making.
Estudio comparativo sobre implantación curricular de salud laboral en grados universitarios de medicina y enfermería
Authors: Ranchal Sánchez Antonio , Romero Saldaña Manuel , Crespo Montero Rodolfo , Montiel Ruiz Elena 
Published: February 2025

Introducción: El objetivo de este estudio era revisar y actualizar la situación de la medicina del trabajo como asignatura en los grados de medicina, y su comparación con la de enfermería del trabajo en los grados de enfermería de las universidades españolas.
Método: Se realizó un estudio de revisión integrativa de literatura tanto científica como gris, siendo la unidad de análisis los planes de estudios de dichos grados universitarios en España durante el curso 2024-2025.
Resultados: Solo un 3% de los centros analizados incluían asignatura obligatoria sobre salud laboral en los grados de medicina, siendo de un 6% en los de enfermería analizados, predominando como optativas en los escasos centros que las ofertaban.
Conclusiones: Las escasas asignaturas obligatorias y específicas de medicina y/o de enfermería del trabajo ofertadas en los planes de estudios identificados pueden servir de modelo para su implantación, de forma generalizada en los estudios universitarios de pregrado de medicina y de enfermería.
Politiques des sexes : la littérature dans la zone à défendre
Authors: Turbiau Aurore 
Published: February 2025

Dans les pays francophones du Nord au cours des années 1970-1980, des écrivaines réfléchissent à ce que sont les « politiques des sexes ». En problématisant certains sujets sociaux et historiques, jusqu’alors soit minorisés, voire ignorés, parce que pensés comme privés, comme de véritables sujets politiques, elles revendiquent et redéfinissent le terme de politique, en réagencent les définitions philosophiques, les zones à défendre, comme les stratégies d’investissement concret qui peuvent concerner les femmes. Le féminisme ne peut se passer de la politique de gouvernement : bien au contraire, il en attend des décisions, en exige des réformes. En même temps, il en conteste l’étroitesse philosophique et éthique, les pragmatiques jamais vraiment satisfaisantes. Le politique présenté par ces écrivaines est plus global que la politique : l’étroitesse des définitions pragmatiques de cette dernière est désignée comme sexiste. Cette même distinction est celle qui sépare leur engagement littéraire d’une écriture politique autoritaire : elle est militante, très certainement ; mais elle n’est pas partisane, et son mode d’action, fondamentalement anarchiste, est bien plus critique que didactique.
БИЛИМ БЕРҮҮДӨГҮ ИННОВАЦИЯЛАР: МЕДИЦИНАЛЫК АДИСТИКТЕРДИН СТУДЕНТТЕРИ ҮЧҮН ЗАМАНБАП ЛАТЫНЧА-КЫРГЫЗЧА ОКУУ СӨЗДҮГҮН ИШТЕП ЧЫГУУ
Authors: Дюшекеева А.К. 
Published: February 2025

Бул тема билим берүүдөгү заманбап тенденцияларды, интерактивдүү окутууга басым жасоо жана заманбап технологияларды колдонуу, атайын окуу материалын – латынча-кыргызча окуу сөздүгүн түзүү зарылчылыгы менен айкалыштырат. Келечектеги медициналык практикада латын терминдерин колдонгон медициналык адистиктердеги студенттердин муктаждыктарын эске алуу маанилүү. Мындай окуу сөздүгү латын тилинин лингвистикалык аспектилерин клиникалык мисалдар жана материалды натыйжалуу өздөштүрүү үчүн заманбап билим берүү методикасы жана ыкмалары менен айкалыштырууга тийиш. Заманбап медициналык билим берүүдө клиникалык көндүмдөр менен теориялык билимдерге гана эмес, латын тилин жана медициналык терминологиянын негиздерин тереңдетип үйрөнүүгө да өзгөчө көңүл бурулат. Медициналык адистиктердин студенттери үчүн заманбап латынча-кыргызча окуу сөздүгүн иштеп чыгуу окуу процессинин негизги элементи болуп, салттуу окутуу ыкмаларын инновациялык ыкмалар менен айкалыштырат.
Эта тема объединяет современные тенденции в образовании, такие как акцент на интерактивное обучение и использование современных технологий, с необходимостью составления специализированного учебного материала – латино-кыргызского учебного словаря. Важно учитывать потребности студентов-медиков, которые используют латинские термины в своей будущей медицинской практике. Такой учебный словарь должен сочетать в себе лингвистические аспекты латинского языка с клиническими примерами и современными образовательными методиками для эффективного усвоения материала. В современном медицинском образовании особое внимание уделяется не только клиническим навыкам и теоретическим знаниям, но и углубленному изучению латинского языка, основы медицинской терминологии. Разработка современного латино-кыргызского учебного словаря для студентов-медиков становится ключевым элементом этого образовательного процесса, объединяя традиционные методы обучения с инновационными подходами.
This topic combines modern trends in education, such as the emphasis on interactive learning and the use of modern technologies, with the need to compile specialized educational material - a Latin-Kyrgyz educational dictionary. It is important to consider the needs of medical students who use Latin terms in their future medical practice. Such an educational dictionary should combine the linguistic aspects of the Latin language with clinical examples and modern educational methods for effective assimilation of the material. In modern medical education, special attention is paid not only to clinical skills and theoretical knowledge, but also to the in-depth study of the Latin language, the basics of medical terminology. The development of a modern Latin-Kyrgyz educational dictionary for medical students is becoming a key element of this educational process, combining traditional teaching methods with innovative approaches.