bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neck Reconstruction (Aiims Box Technique) in the Management of Large Femoral Neck Defects
Authors: Garg Bhavuk , Upendra Bidre N. , Jayaswal Arvind 
Published: January 2011

Large femoral neck defects are frequently associated with neglected femoral neck fractures, sequelae of infection, and failed fixation devices. The AIIMS box technique of neck reconstruction has the objectives of femoral head preservation and restoration of hip function in such cases. 32 patients (age range 20–56, average 38 years) with large femoral neck defects were treated from January 1990 to May 1997 and were followed up for a minimum of 10 years (range 10 to 17 years). The neck defect was converted into a box using osteal flaps (base from greater trochanter, anterior wall from head, quadratus femoris muscle pedicle graft posteriorly), which was filled with cancellous bone autograft, and stabilized with cancellous screws. Union occurred in all patients in a mean time of 16 weeks (range 12–20 weeks). One patient developed avascular necrosis (AVN) of femoral head. 8 out of 32 results were classified as excellent, 22 good and 2 fair. Good functional mobility was seen in all but two patients. Complications included coxa vara in two patients, and fixation problems in four patients. Large femoral neck defects can be managed successfully by this technique with preservation of the viability of the femoral head, and therefore the procedure should be considered in appropriate cases, particularly in young adults.
Isolated del(5q) in myeloid malignancies: Clinicopathologic and molecular features in 143 consecutive patients
Authors: Patnaik Mrinal M. , Lasho Terra L. , Finke Christy M. , Knudson Ryan A. , Ketterling Rhett P. , Chen Dong , Hoyer James D. , Hanson Curtis A. , Tefferi Ayalew 
Published: January 2011

AbstractWorld Health Organization (WHO) criteria were used to identify 143 consecutive patients (median age 73 years; 90 females) with myeloid neoplasms and isolated del(5q) seen between 1989 and 2009. We have previously reported on 88 (61%) of these patients who met criteria for WHO defined “myelodysplastic syndromes (MDS) with isolated del(5q).” The remaining 55 patients were classified as having “other” MDS variants (n = 29; 20%), acute myeloid leukemia (AML; n = 14; 10%), or myeloproliferative neoplasms (MPN; n = 12; 8%). DNA was available in 138 patients and mutation screening revealed 20 cases with JAK2, 6 with IDH, and 3 with MPL mutations; JAK2 and MPL mutations were seen mostly in MPN or “MDS with isolated del(5q)” whereas IDH mutations were frequent in other MDS variants. Overall median survival for the 143 patient cohort was 35 months and leukemic transformation (LT) was documented in 19 (∼13%) cases. “MDS with isolated del(5q)” had the best prognosis with median survival of 66 months and LT rate of ∼6%. Survival was poor among the other myeloid neoplasm subgroups regardless of specific morphologic diagnosis. Multivariable analysis identified higher leukocyte count and percentage of bone marrow and circulating blasts as independent predictors of shortened survival. The first two parameters and the presence of IDH mutations predicted inferior leukemia‐free survival. The current study validates the prognostic relevance of considering “MDS with isolated del(5q)” as a separate WHO subcategory and identifies leukocytosis, higher blast count, and IDH mutations as being prognostically detrimental, in myeloid neoplasms associated with isolated del(5q). Am. J. Hematol. 86:393–398, 2011. © 2011 Wiley‐Liss, Inc.
Long‐term results using hydroxyurea/phlebotomy for reducing secondary stroke risk in children with sickle cell anemia and iron overload
Authors: Greenway Anthea , Ware Russell E. , Thornburg Courtney D. 
Published: January 2011

AbstractChildren with sickle cell anemia (SCA) and a primary overt stroke are at high risk of recurrent (secondary) stroke. Chronic transfusion therapy dramatically reduces but does not eliminate this high risk, and inevitably results in transfusion‐related hemosiderosis. We previously reported the use of hydroxyurea/phlebotomy as an alternative to transfusions to reduce the risk of secondary stroke and improve management of iron overload in 35 children with SCA. To report long‐term results, we retrospectively reviewed clinical and laboratory data through October 2008. With a median of 5.6 years and total of 219 patient‐years of follow‐up, 10 of 35 patients (29%) had recurrent stroke after switching to hydroxyurea; seven were previously reported and three new strokes occurred during extended follow‐up. The overall secondary stroke event rate was 4.6 per 100 patient‐years. Children on hydroxyurea received serial phlebotomy and had lower mean serum ferritin values than children on transfusions (591 ng/mL vs. 3410 ng/mL, P = 0.02). In this cohort, long‐term hydroxyurea treatment reduced but did not eliminate the risk of stroke recurrence and, uniquely, allowed phlebotomy to reduce iron overload. Long‐term assessments of this therapy should evaluate risk factors for secondary stroke and assessments of hemosiderosis, neurocognitive outcome, and health‐related quality of life. Am. J. Hematol. 86:357–361, 2011. © 2011 Wiley‐Liss, Inc.
PEGylated Inorganic Nanoparticles
Authors: Karakoti Ajay S. , Das Soumen , Thevuthasan Suntharampillai , Seal Sudipta 
Published: January 2011

AbstractApplication of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long‐term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides “stealth” characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure‐directing agent in synthesis of oxides is also presented.
Polyethylene glycol‐bound Ru catalyst for asymmetric transfer hydrogenation of aromatic ketones in water
Authors: Zhou Zhongqiang , Ma Qiong 
Published: January 2011

AbstractA new polyethylene glycol‐supported chiral monosulfonamide was synthesized from (R,R)‐1,2‐diaminocyclohexane and shown to act as a ligand for ruthenium(II)‐catalyzed asymmetric transfer hydrogenation of aromatic ketones in neat water using sodium formate as the hydrogen source. Good enantioselectivities were obtained and the catalyst could be easily separated from the reaction mixture and reused several times. Copyright © 2011 John Wiley & Sons, Ltd.
The changing faces of HP1: From heterochromatin formation and gene silencing to euchromatic gene expression
Authors: Kwon So Hee , Workman Jerry L. 
Published: January 2011

AbstractHeterochromatin protein 1 (HP1) is a positive regulator of active transcription in euchromatin. HP1 was first identified inDrosophila melanogasteras a major component of heterochromatin. Most eukaryotes have at least three isoforms of HP1, which are conserved in overall structure but localize differentially to heterochromatin and euchromatin. Although initial studies revealed a key role for HP1 in heterochromatin formation and gene silencing, recent progress has shed light on additional roles for HP1 in processes such as euchromatic gene expression. Recent studies have highlighted the importance of HP1‐mediated gene regulation in euchromatin. Here, we focus on recent advances in understanding the role of HP1 in active transcription in euchromatin and how modification and localization of HP1 can regulate distinct functions for this protein in different contexts.
Nanoengineered PtVFe/C Cathode Electrocatalysts in PEM Fuel Cells: Catalyst Activity and Stability
Authors: Fang Bin , Luo Jin , Chen Yongsheng , Wanjala Bridgid N. , Loukrakpam Rameshwori , Hong Jian , Yin Jun , Hu Xiang , Hu Peipei , Zhong Chuan‐Jian 
Published: January 2011

AbstractThe understanding of factors controlling electrocatalytic activity and stability of carbon‐supported multimetallic catalysts is essential for advancing the design of fuel‐cell electrocatalysts for oxygen reduction. The structural and compositional changes of trimetallic PtVFe/C catalysts have been investigated by several techniques, including XRD, X‐ray absorption fine structure (XAFS), and inductively coupled plasma (ICP) analyses, in addition to electrochemical and fuel‐cell performance tests. The investigation aims at understanding whether the base metals incorporated into the multimetallic catalysts are stable and how the base metals in the Pt‐alloy are stabilized mechanistically. Changes are detected for the lattice properties and the composition of the base metals in the PtVFe nanoparticles after long‐term exposure to air, after thermal treatment at different temperatures, and after use in proton‐exchange membrane (PEM) fuel cells. These changes show certain correlations with the structure, activity, and stability of the catalysts. The fcc alloy phase is found to be predominant for catalysts treated at low temperature, but changes to a tetragonal‐type alloy phase when the catalysts are treated at a higher temperature. In the low‐temperature‐treated catalyst, Fe has more bonds with O atoms, whereas in the high‐temperature‐treated catalyst, Fe has fewer O neighbors and FeFe bonds are detected. Analysis of the catalysts after testing in fuel cells indicates that the percentage of iron oxide is reduced, reflecting the propensity of dissolution of Fe oxide in the electrolytes. The smaller lattice parameter for the higher‐temperature treated catalyst is considered to be an important factor in determining the catalyst stability under conditions related to fuel‐cell operation.
Oligonuclear Ferrocene Amides: Mixed‐Valent Peptides and Potential Redox‐Switchable Foldamers
Authors: Siebler Daniel , Linseis Michael , Gasi Teuta , Carrella Luca M. , Winter Rainer F. , Förster Christoph , Heinze Katja 
Published: January 2011

AbstractTrinuclear ferrocene tris‐amides were synthesized from an Fmoc‐ or Boc‐protected ferrocene amino acid, and hydrogen‐bonded zigzag conformations were determined by NMR spectroscopy, molecular modelling, and X‐ray diffraction. In these ordered secondary structures orientation of the individual amide dipole moments approximately in the same direction results in a macrodipole moment similar to that of α‐helices composed of α‐amino acids. Unlike ordinary α‐amino acids, the building blocks in these ferrocene amides with defined secondary structure can be sequentially oxidized to mono‐, di‐, and trications. Singly and doubly charged mixed‐valent cations were probed experimentally by Vis/NIR, paramagnetic 1H NMR and Mössbauer spectroscopy and investigated theoretically by DFT calculations. According to the appearance of intervalence charge transfer (IVCT) bands in solution, the ferrocene/ferrocenium amides are described as Robin–Day class II mixed‐valent systems. Mössbauer spectroscopy indicates trapped valences in the solid state. The secondary structure of trinuclear ferrocene tris‐amides remains intact (coiled form) upon oxidation to mono‐ and dications according to DFT calculations, while oxidation to the trication should break the intramolecular hydrogen bonding and unfold the ferrocene peptide (uncoiled form).
1,2‐Diphosphaacenaphthene 1,2‐Dications: Synthetic, Stereochemical and Computational Study of the Stabilising Role of Naphthalene‐1,8‐diyl Backbone
Authors: Somisara D. M. Upulani K. , Bühl Michael , Lebl Tomas , Richardson Neville V. , Slawin Alexandra M. Z. , Woollins J. Derek , Kilian Petr 
Published: January 2011

AbstractSyntheses and full characterisation data (including single crystal diffraction) of three 1,2‐diphosphonium dicationic species with the naphthalene‐1,8‐diyl (Nap) backbone are reported. The oxidation of Nap[P(NMe2)2]2 with P2I4 to its 1,2‐dication was achieved. meso‐ and rac‐forms of “all carbon” 1,2‐diphosphonium dications were obtained in good yields and purity by double alkylation of the parent diphosphine (1,2‐diphenyl‐1,2‐diphosphaacenaphthene) with methyl triflate or trimethyloxonium tetrafluoroborate. Each methylating reagent produces one of the rac‐ or meso‐forms of the dication diastereospecifically. Structural parameters of the new dications are discussed with respect to other phosphorus 1,2‐dications. DFT (B3LYP) computations revealed the significant role of the naphthalene backbone in stabilisation of the dicationic motif and helped to assess the energy cost of the steric clash of a variety of groups attached to the peri‐positions of naphthalene. The synthesis and single crystal X‐ray data of the extremely crowded Nap[P(Se)(OiPr)2]2 are discussed, and are contrasted with the unsuccessful synthesis of Nap(PtBu2)2 from NapLi2 and ClPtBu2.
Copper(I) and Copper(II) Inhibit Aβ Peptides Proteolysis by Insulin‐Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer’s Disease
Authors: Grasso Giuseppe , Pietropaolo Adriana , Spoto Giuseppe , Pappalardo Giuseppe , Tundo Grazia Raffaella , Ciaccio Chiara , Coletta Massimo , Rizzarelli Enrico 
Published: January 2011

AbstractAccumulation of neurotoxic amyloid‐β peptide (Aβ) and alteration of metal homeostasis (metallostasis) in the brain are two main factors that have been very often associated with neurodegenerative diseases, such as Alzheimer’s disease (AD). Aβ is constantly produced from the amyloidprecursor‐protein APP precursor and immediately catabolized under normal conditions, whereas dysmetabolism of Aβ and/or metal ions seems to lead to a pathological deposition. Although insulin‐degrading enzyme (IDE) is the main metalloprotease involved in Aβ degradation in the brain being up‐regulated in some areas of AD brains, the role of IDE for the onset and development of AD is far from being understood. Moreover, the biomolecular mechanisms involved in the recognition and interaction between IDE and its substrates are still obscure. In spite of the important role of metals (such as copper, aluminum, and zinc), which has brought us to propose a “metal hypothesis of AD”, a targeted study of the effect of metallostasis on IDE activity has never been carried out. In this work, we have investigated the role that various metal ions (i.e., Cu2+, Cu+, Zn2+, Ag+, and Al3+) play in modulating the interaction between IDE and two Aβ peptide fragments, namely Aβ1–16 and Aβ16–28. It was therefore possible to identify the direct effect that such metal ions have on IDE structure and enzymatic activity without interferences caused by metal‐induced substrate modifications. Mass spectrometry and kinetic studies revealed that, among all the metal ions tested, only Cu2+, Cu+, and Ag+ have an inhibitory effect on IDE activity. Moreover, the inhibition of copper(II) is reversed by adding zinc(II), whereas the monovalent cations affect the enzyme activity irreversibly. The molecular basis of their action on the enzyme is also discussed on the basis of computational investigations.
ChemInform Abstract: Magnetic Properties and Structural Transitions of Orthorhombic Fluorite‐Related Compounds Ln3MO7 (Ln = Rare Earths, M = Transition Metals).
Authors: Wakeshima Makoto , Hinatsu Yukio 
Published: January 2011

AbstractThe compounds Ln3MoO7 (Ln: La—Gd) are synthesized using the corresponding rare earth oxides, MoO2, and MoO3 as starting materials (1200 °C, 12 h).
ChemInform Abstract: How Does the Synthesis Temperature Impact Hybrid Organic—Inorganic Molybdate Material Design?
Authors: Dessapt Remi , Kerkern Daniel , Bujoli‐Doeuff Martine , Deniard Philippe , Evain Michel , Jobic Stephane 
Published: January 2011

AbstractThe detailed study of the reactions of MoO42‐ with different ethylenediammonium cations at temperatures in the range 70—180 °C yields a variety of new molybdates with different topologies.
ChemInform Abstract: Direct Asymmetric Bromination of Aldehydes Catalyzed by a Binaphthyl‐Based Secondary Amine: Highly Enantio‐ and Diastereoselective One‐Pot Synthesis of Bromohydrins.
Authors: Kano Taichi , Shirozu Fumitaka , Maruoka Keiji 
Published: January 2011

AbstractThe bromination of aldehydes (I) in the presence of a chiral binaphthyl catalyst (BNS) followed by reduction of the intermediate α‐bromoaldehyde gives rise to bromohydrins (II) with high enantioselectivity.
ChemInform Abstract: Mild and Expedient Asymmetric Reductions of α,β‐Unsaturated Alkenyl and Alkynyl Ketones by TarB—NO2 and Mechanistic Investigations of Ketone Reduction.
Authors: Eagon Scott , DeLieto Cassandra , McDonald William J. , Haddenham Dustin , Saavedra Jaime , Kim Jinsoo , Singaram Bakthan 
Published: January 2011

AbstractThe title reactions allow a facile, chemoselective, and enantioselective access to allylic and propargyl alcohols.
ChemInform Abstract: Heck Coupling Reaction Using Monomeric ortho‐Palladated Complex of 4‐Methoxybenzoylmethylenetriphenylphosphorane under Microwave Irradiation.
Authors: Hajipour Abdol R. , Karami Kazem , Tavakoli Ghazal 
Published: January 2011

AbstractThe title reaction can be carried out under both conventional heating and microwave irradiation conditions.
ChemInform Abstract: P[N(i‐Bu)CH2CH2]3N: Nonionic Lewis Base for Promoting the Room‐Temperature Synthesis of α,β‐Unsaturated Esters, Fluorides, Ketones, and Nitriles Using Wadsworth—Emmons Phosphonates.
Authors: Chintareddy Venkat Reddy , Ellern Arkady , Verkade John G. 
Published: January 2011

AbstractThe use of the title base allows convenient access to α,β‐unsaturated esters, fluorides, ketones, and nitriles.
ChemInform Abstract: Highly Stereoselective and Scalable anti‐Aldol Reactions Using N‐(p‐Dodecylphenylsulfonyl)‐2‐pyrrolidinecarboxamide: Scope and Origins of Stereoselectivities.
Authors: Yang Hua , Mahapatra Subham , Cheong Paul Ha‐Yeon , Carter Rich G. 
Published: January 2011

AbstractIt is found that the carboxamide PRO efficiently promotes asymmetric addition of a wide range of aldehydes to various ketones.
ChemInform Abstract: Water‐Compatible Iminium Activation: Highly Enantioselective Organocatalytic Michael Addition of Malonates to α,β‐Unsaturated Enones.
Authors: Mao Zhifeng , Jia Yaomei , Li Wenyi , Wang Rui 
Published: January 2011

AbstractIt is found that a combination of TFA with the diamine shown is optimal.
ChemInform Abstract: Enamides Accessed from Aminothioesters via a Pd(0)‐Catalyzed Decarbonylative/β‐Hydride Elimination Sequence.
Authors: Min Geanna K. , Hernandez Dacil , Lindhardt Anders T. , Skrydstrup Troels 
Published: January 2011

AbstractThe process can be applied to a broad spectrum of substrates to produce the (E) isomers as the main components.
ChemInform Abstract: Efficient Photochemical Synthesis of 2‐Vinylcyclopropanecarbaldehydes, Precursors of Cyclopropane Components Present in Pyrethroids, by Using the Oxa‐di‐π‐methane Rearrangement.
Authors: Armesto Diego , Ortiz Maria J. , Agarrabeitia Antonia R. , El‐Boulifi Noureddin 
Published: January 2011

AbstractThe triplet‐sensitized photolysis of dienic aldehydes of type (I) and (III) is investigated in the presence of 4‐phenylbenzophenone as sensitizer.
ChemInform Abstract: Eleuthesides and Their Analogues. Part 1. Synthesis of the Base Compound from Levoglucosenone Adduct with Piperylene.
Authors: Kondrova Yu. A. , Krasnoslobodtseva O. Yu. , Spirikhin L. V. , Valeev F. A. 
Published: January 2011

AbstractThe Diels‐Alder adduct (I) of levoglucosenone and piperylene is used as starting compound for the synthesis of aldehyde (VII), a building block for the synthesis of eleutheside analogues.
ChemInform Abstract: Copper‐Catalyzed One‐Pot Synthesis of Propargylamines via C—H Activation in PEG.
Authors: Zhang Qiang , Chen Jiu‐Xi , Gao Wen‐Xia , Ding Jin‐Chang , Wu Hua‐Yue 
Published: January 2011

AbstractThe three‐component A3 coupling reaction of aldehyde, amine, and alkyne is carried out for the first time using PEG as the solvent.
ChemInform Abstract: Highly Active Water‐Soluble and Recyclable Organocatalyst for the Asymmetric 1,4‐Conjugate Addition of Nitroalkanes to α,β‐Unsaturated Aldehydes.
Authors: Ghosh Subrata K. , Zheng Zilong , Ni Bukuo 
Published: January 2011

AbstractA diarylprolinol silyl ether in combination with benzoic acid efficiently catalyzes the addition reaction.
ChemInform Abstract: Bismuth(III) Oxide Catalyzed Oxidation of Alcohols with tert‐Butyl Hydroperoxide.
Authors: Malik Payal , Chakraborty Debashis 
Published: January 2011

AbstractThe Bi2O3‐mediated oxidation of primary and secondary alcohols (I) and (III) to carboxylic acids (II) and ketones (IV) does not depend on ligands or other additives.
ChemInform Abstract: A Highly Diastereoselective Synthesis of α‐Hydroxy‐β‐amino Acid Derivatives via a Lewis Acid Catalyzed Three‐Component Condensation Reaction.
Authors: Gassa Federico , Contini Alessandro , Fontana Gabriele , Pellegrino Sara , Gelmi Maria Luisa 
Published: January 2011

AbstractA highly diastereoselective and very efficient method to prepare title compounds is reported.
ChemInform Abstract: Catalytic Enantioselective Arylation of Glyoxylate with Arylsilanes: Practical Synthesis of Optically Active Mandelic Acid Derivatives.
Authors: Aikawa Kohsuke , Hioki Yuta , Mikami Koichi 
Published: January 2011

AbstractThe presence of the silyl group plays a crucial role as it increases the reactivity and completely controls the regioselectivity of the desired arylation.
ChemInform Abstract: Synthesis, Characterization and Application of Poly(4‐methyl vinylpyridinium hydroxide)/SBA‐15 Composite as a Highly Active Heterogeneous Basic Catalyst for the Knoevenagel Reaction.
Authors: Kalbasi Roozbeh Javad , Kolahdoozan Majid , Massh Ahmadreza , Shahabian Keinaz 
Published: January 2011

AbstractThe novel basic polymeric composite exhibits excellent catalytic activity for the Knoevenagel condensation of aromatic aldehydes (I) and (IV) with ethyl cyanoacetate (II).
ChemInform Abstract: Copper(II) Triflate‐Catalyzed Three‐Component Coupling of Aldehydes, Alkynes and Carbamates.
Authors: Dou Xiao‐Yong , Shuai Qi , He Liang‐Nian , Li Chao‐Jun 
Published: January 2011

AbstractNo co‐catalyst or ligand is required for the title reaction affording propargylcarbamates from aromatic aldehydes and aromatic alkynes.
ChemInform Abstract: Liquid‐Phase Synthesis of Biaryl Compounds by the Hydrogenolysis of Pentaerythritol‐Supported Biarylsulfonates.
Authors: Kim Chul‐Bae , Lee Sung‐Kyung , Park Kwangyong 
Published: January 2011

AbstractPentaerythritol turns out to be an efficient soluble tetrapodal support permitting the traceless release of various biaryl compounds attached by a sulfonate linkage.
ChemInform Abstract: Synthesis and Molecular Structure of Symmetrical 1,8‐Diarylnaphthalenes.
Authors: Pieters Gregory , Terrasson Vincent , Gaucher Anne , Prim Damien , Marrot Jerome 
Published: January 2011

AbstractFourteen 1,8‐diarylnaphthalenes such as (III) are prepared using a reliable and general bis‐Suzuki methodology.
ChemInform Abstract: Tailored α‐Methylene‐γ‐butyrolactones and Their Effects on Growth Suppression in Pancreatic Carcinoma Cells.
Authors: Ramachandran P. Veeraraghavan , Pratihar Debarshi , Nair Hari‐Narayanan G. , Walters Matthew , Smith Sadie , Yip‐Schneider Michele T. , Wu Huangbing , Schmidt C. Max 
Published: January 2011

AbstractA series of racemic α‐methylene‐γ‐butyrolactones is synthesized and screened against three human pancreatic cancer cell lines.
ChemInform Abstract: Synthesis, Characterization and Biological Activities of Novel (E)‐3‐(1‐(Alkyloxyamino)ethylidene)‐1‐alkylpyrrolidine‐2,4‐dione Derivatives.
Authors: Zhu Zhao‐Yong , Shi Qing‐Ming , Han Bao‐Feng , Wang Xian‐Feng , Qiang Sheng , Yang Chun‐Long 
Published: January 2011

AbstractAlkylamino substituents are introduced into the pyrrolidinedione core to synthesize twenty novel tetramic acid derivatives having an oxime ether moiety at the 3‐position.
ChemInform Abstract: Formation of γ‐Oxoacids and 1H‐Pyrrol‐2(5H)‐ones from α,β‐Unsaturated Ketones and Ethyl Nitroacetate.
Authors: Aginagalde Maialen , Bello Tamara , Masdeu Carme , Vara Yosu , Arrieta Ana , Cossio Fernando P. 
Published: January 2011

AbstractAddition of the nitroacetate (II) to enones followed by treatment with H2O2/ K2CO3 is found to afford γ‐oxoacids like (III).