bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed tomography angiography or invasive coronary angiography in patients with lowto intermediate risk acute coronary syndrome — a single-center study
Authors: Kuznetsova K. V. , Bikbaeva G. R. , Sukhinina E. M. , Taumova G. Kh. , Benyan A. S. , Duplyakov D. V. , Tukhbatova A. A. , Adonina E. V. , Kislukhin T. V. , Nagornova V. V. 
Published: April 2024

Aim. To evaluate the strategy of using coronary computed tomography angiography (CCTA) in patients with low-to-intermediate risk of non-ST segment elevation acute coronary syndrome (NSTE-ACS) in relation to early (in-hospital) and long-term prognosis in comparison with standard management tactics.Material and methods. The study included 259 patients (men (M), 47,9%, mean age, 62,2±9,4 years). Patients in group 1 (n=148 people, M 46,6%, mean age 61,99±9,92 years) underwent CCTA to assess coronary involvement, and patients in group 2 (n=111 people, M 49,5%, mean age 62,4±8,6 years) — invasive coronary angiography (ICA). The follow-up lasted 18 months.Results. Patients in both groups were comparable in age, concomitant chronic diseases and smoking. Patients in the CCTA group compared with the ICA group had lower GRACE score and lower values of high-sensitivity Troponin I. In 85 patients (57,4%) of group 1 there was no coronary involvement, while 41 patients (27,7%) had <50% stenosis, 22 patients (14,9%) — >50% stenosis in at least one coronary artery. In group 2, the majority of patients also had non-involved coronary vessels (n=76; 68,5%), while hemodynamically insignificant (20-40%) and significant lesions were detected in 20 patients (12,3%) and 15 people (13,5%), respectively. In group 1, 20 patients were referred for ICA as follows: 10 patients underwent percutaneous coronary interventions; 2 patients had multivessel disease; in 4 patients, intraoperative fractional flow reserve revealed hemodynamically insignificant stenoses; in 4 remaining patients, no significant lesions were detected. All-cause mortality was 4,05% in the CCTA group, and 7,2% in the ICA group (p=0,28). In the CCTA group, cardiovascular mortality was 0%, and in the ICA group — 0,9% (p=0,43).Conclusion. CCTA in patients with low-to-intermediate risk ACS is not inferior to the standard tactics for managing these patients and significantly reduces the need for iCAG.
Possible risk factors for atrial fibrillation in patients with heart failure with mildly reduced ejection fraction
Authors: Azarapetyan L. G. , Hayrapetyan G. G. , Grigoryan S. V. 
Published: April 2024

Aim. To study possible risk factors (RFs) for the development of paroxysmal and persistent atrial fibrillation (AF) in patients with heart failure with mildly reduced ejection fraction (HFmrHF).Material and methods. The study included 193 patients with chronic HFmrHF and non-valvular paroxysmal/persistent AF. Seventy-six comparable patients, but without AF, were studied as a control group. All patients underwent a detailed physical examination, including electrocardiography (ECG), echocardiography, ambulatory blood pressure monitoring, and Holter ECG monitoring. Levels of inflammatory markers, namely high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-a and fibrotic marker, transforming growth factor-b1 (TGF-b1) were measured using ELISA. The results obtained were analyzed using the method of binary logistic regression and odds ratio (OR), which allows us to assess the relationship of a specific outcome with possible risk factors and compare study groups according to the detection rate of risk factors.Results. A higher level of diastolic blood pressure (DBP) (OR=1,09, confidence interval (CI)=1,01-1,17, p=0,017) is a possible risk factor for paroxysmal AF in patients with CHF. Possible risk factors for paroxysmal and persistent AF in such patients are an increase in episodes of hypertensive crisis (OR=1,17, CI=1,071,43, p=0,001) and an increase in body mass index (BMI) (OR=1,13, CI=0,931,27, p=0,031). An increase in the OR index of left ventricular diastolic and systolic parameters was associated with significant atrial and ventricular remodeling, which contributes to AF progression from paroxysmal to persistent. Higher levels of inflammatory markers were observed in patients with AF compared with patients with HFmrHF without AF. The increase in the OR level of TGF-b1 (OR=3,84, CI=2,106,23, p=0,005) was significant in patients with persistent AF.Conclusion. Using the OR method, an increase in DBP, the prevalence of hypertensive crisis, BMI, left atrial and ventricular remodeling, an increase in markers of systemic inflammation and fibrosis are possible risk factors for AF in patients with HFmrHF.
Plasma Proteins Associated with Chronic Histopathologic Lesions on Kidney Biopsy
Authors: Kim Taesoo , Surapaneni Aditya L. , Schmidt Insa M. , Eadon Michael T. , Kalim Sahir , Srivastava Anand , Palsson Ragnar , Stillman Isaac E. , Hodgin Jeffrey B. , Menon Rajasree , Otto Edgar A. , Coresh Josef , Grams Morgan E. , Waikar Sushrut S. , Rhee Eugene P. ,   for the Kidney Precision Medicine Project
Published: April 2024

Key Points

Proteomic profiling identified 35 blood proteins associated with chronic histopathologic lesions in the kidney.Testican-2 was expressed in the glomerulus, released by the kidney into circulation, and inversely associated with glomerulosclerosis severity.NELL1 was expressed in tubular epithelial cells, released by the kidney into circulation, and inversely associated with interstitial fibrosis and tubular atrophy severity.

Background
The severity of chronic histopathologic lesions on kidney biopsy is independently associated with higher risk of progressive CKD. Because kidney biopsies are invasive, identification of blood markers that report on underlying kidney histopathology has the potential to enhance CKD care.

Methods
We examined the association between 6592 plasma protein levels measured by aptamers and the severity of interstitial fibrosis and tubular atrophy (IFTA), glomerulosclerosis, arteriolar sclerosis, and arterial sclerosis among 434 participants of the Boston Kidney Biopsy Cohort. For proteins significantly associated with at least one histologic lesion, we assessed renal arteriovenous protein gradients among 21 individuals who had undergone invasive catheterization and assessed the expression of the cognate gene among 47 individuals with single-cell RNA sequencing data in the Kidney Precision Medicine Project.

Results
In models adjusted for eGFR, proteinuria, and demographic factors, we identified 35 proteins associated with one or more chronic histologic lesions, including 20 specific for IFTA, eight specific for glomerulosclerosis, and one specific for arteriolar sclerosis. In general, higher levels of these proteins were associated with more severe histologic score and lower eGFR. Exceptions included testican-2 and NELL1, which were associated with less glomerulosclerosis and IFTA, respectively, and higher eGFR; notably, both of these proteins demonstrated significantly higher levels from artery to renal vein, demonstrating net kidney release. In the Kidney Precision Medicine Project, 13 of the 35 protein hits had cognate gene expression enriched in one or more cell types in the kidney, including podocyte expression of select glomerulosclerosis markers (including testican-2) and tubular expression of several IFTA markers (including NELL1).

Conclusions
Proteomic analysis identified circulating proteins associated with chronic histopathologic lesions, some of which had concordant site-specific expression within the kidney.
Gait analysis characteristic features in children with spastic hemiplegia
Authors: Mamedov U. F. , Dolganova T. I. , Gatamov O. I. , Popkov D. A. 
Published: April 2024

Introduction There are not enough published studies on the impact of early isolated triceps lengthening operations in hemiparesis on the state of motor characteristics and on the development of orthopedic complications in children with GMFCS II.Purpose Analyze motor locomotion in children with spastic hemiplegia who had not previously been operated on and those who had undergone isolated surgical lengthening of the triceps at an early age.Material and methods Four groups of children with spastic hemiplegia according to Rodda et Graham types: I) type 2a gait (4 children), II) type 3 (3 children), III) type 4 (7 children), IV) type 4 with previous triceps lengthening (9 children).Results The features revealed in gait types 2a, 3 and 4 in the sagittal plane correspond to the characteristic and previously described features. In all groups, asymmetric rotational movements of the pelvis and tilt asymmetry in the frontal plane were observed. In the group of early isolated tricep lengthening, a decrease in the moment of force by pushing with the foot at the end of the single-support phase was revealed, in combination with an increase in the moment of forces of knee joint extension in the single-support phase.Discussion Early isolated triceps lengthening that weakens its function leads to a compensatory increase in the work of the knee extensors which is similar to the mechanism to of iatrogenic crouch gait, but does not result in a complete loss of walking function in the conditions of a contralateral healthy limb.Conclusions Movement pathology is present in all three measurement planes in gait types 2a, 3, 4 according to the Rodda et Graham classification. The most pronounced deviations were found in gait type 3. The rotational turn of the pelvis is an initially compensatory mechanism due to intratorsion femur deformity. Isolated triceps lengthening surgeries performed at an early age lead to reduced plantar push strength, increased compensatory work of the knee extensors, and probably do not prevent the orthopedic pathology found in Rodda et Graham's gait type 4.
SUP-Hesitant Fuzzy Interior Ideals in \(\Gamma\)-Semigroups
Authors: Khamrot Pannawit , Gaketem Thiti 
Published: April 2024

In this paper, we defined the concept \(\mathcal{SUP}\)-hesitant fuzzy interior ideals in \(\Gamma\)-semigroups, which is generalized of hesitant fuzzy interior ideals in \(\Gamma\)-semigroups. Additionally, we study fundamental properties of \(\mathcal{SUP}\)-hesitant fuzzy interior ideals in \(\Gamma\)-semigroups. Finally, we investigate characterized properties of those.
Black Feminism and Womanism: A Narrative Review of the Weight Loss Literature
Authors: Blackman Carr Loneke T. , Barlow Jameta Nicole 
Published: April 2024

Objective
Black Feminism and Womanism offers an interdisciplinary lens and practice to center Black women’s health, engage relevant health, and create Black women–informed solutions to address obesity. The purpose of this review article is to employ Black Feminism and Womanism to examine approaches and results of Black women–centered behavioral weight loss interventions.

Methods
A narrative review of Black women–centered behavioral weight loss interventions was conducted. To be included, articles met the following criteria: published between 2012 and 2022, standard behavioral treatment for weight loss, randomized design, weight loss outcomes stratified by race and gender, sample size of at least 75 individuals, adults at least 18 years of age, and at least 51% Black women in the sample.

Results
Eight studies met the inclusion criteria for a Black women–centered behavioral weight loss intervention and were evaluated. Findings indicate that weight loss among Black women was mostly low, below the clinical target of 5 to 10% weight loss. Intervention designs ranged widely in their approach to respond to the context of Black women’s lives, with little consistency between designs.

Conclusions
To make meaningful improvement in the effectiveness of behavioral weight loss interventions for Black women, new approaches are critical. Approaches grounded in Black Feminism and Womanism can provide the essential foundation to generate new knowledge, novel hypotheses, and intervention designs that fully attend to the lived context of Black women, including consideration of the potential health effects of gendered racism.
Developing a Social Determinants of Health Needs Assessment for Colorado Kids (SNACK) Tool for a School-Based Asthma Program: Findings from a Pilot Study
Authors: Brewer Sarah E. , DeCamp Lisa R. , Reedy Julia , Armstrong Rachel , DeKeyser Heather H. , Federico Monica J. , McFarlane Arthur , Figlio Gino , Huebschmann Amy G. , Szefler Stanley J. , Cicutto Lisa 
Published: April 2024

Background
School-based asthma programs effectively address poorly controlled asthma and asthma disparities, especially when coupled with screening for and addressing social determinants of health (SDOH) needs. Existing screening tools are tailored to clinical settings; therefore, we sought to develop a community-based SDOH screening tool.

Design/Methods
We used a four-phase iterative design process to develop and pilot a community-based screening tool. We used a modified Delphi process to identify screening tool domains, identified validated items for inclusion, and developed an appropriate tool layout for populations with limited health/general literacy. Community advisory boards reviewed and refined a draft tool. Next, we conducted a qualitative pilot test of acceptability to parents and feasibility for staff in a community health center.

Results
Six domains are included in our SDOH screening tool: health care access, transportation, food insecurity, public benefits, housing, and utilities. In the pilot test, 41 screenings were completed, and 36 parents (16.7% Spanish speaking) provided feedback. Most families understood the purpose of the screening; felt that the questions were clear, appropriate, and quick to complete; and liked the pictures. The clinic’s care coordinator expressed a preference for the pilot tool compared to their existing screening tool and recommended improvements to encourage honest reporting by patients.

Conclusion
This community-based screening tool addresses key SDOH needs that impact asthma and is acceptable to families. The next steps are to implement the tool in school-based asthma programs to support improvements in asthma outcomes and disparities by identifying and addressing families’ unmet SDOH needs.
Understanding Core Community Needs for School-Based Asthma Programming: A Qualitative Assessment in Colorado Communities
Authors: Brewer Sarah E. , Reedy Julia , Maestas Danielle , DeCamp Lisa Ross , Begum Anowara , Brtnikova Michaela , Cicutto Lisa , Szefler Stanley J. , Huebschmann Amy 
Published: April 2024

Objectives
Asthma is one of the most prevalent chronic conditions affecting approximately 8.5% of children in Colorado. Our school-based asthma program (SBAP) has effectively improved asthma control and reduced asthma disparities among children but has been largely limited to the Denver area. We interviewed community stakeholders in 5 regions of Colorado to understand community needs for broader dissemination of SBAPs.

Methods
In-depth, semistructured key informant interviews were conducted with school nurses, parents, pediatric healthcare providers, public health professionals, and community resource organization representatives. Inductive and deductive analyses were informed by the practical, robust, implementation, and sustainability model, an implementation science framework.

Results
Participants (n=52) identified 6 types of needs for successful future implementation of our SBAP: (1) buy-in from stakeholders; (2) asthma prioritization; (3) improved relationships, communication, and coordination among school nurses, healthcare providers, and community organizations that address social determinants of health (SDOH) and children/families; (4) resources to address healthcare and SDOH needs and awareness of existing resources; (5) asthma education for children/families, school staff, and community members; and (6) improved coordination for School Asthma Care Plan completion. These needs mapped to a 3-tiered, progressive structure of foundational, relational, and functional needs for implementation success.

Conclusion
These 6 types of needs illuminate factors that will allow this SBAP to work well and program delivery approaches and implementation strategies that may need modification to be successful. Next steps should include tailoring implementation strategies to variations in local context to support fit, effectiveness, and sustainment.
Key Principles Underlying a Research-Practice Alignment in a Federally Qualified Health Center
Authors: Schoenthaler Antoinette , Colella Doreen , De La Calle Franze , Bueno Gisella , Nay Jacalyn , Garcia Masiel , Shahin George , Gago Cristina , Dapkins Isaac 
Published: April 2024

Context
Minoritized populations such as racial and ethnic minorities and individuals of less privileged socioeconomic status experience a disproportionate burden of poor hypertension (HTN) control in the United States. Multilevel systems interventions have been shown to improve patient-level outcomes in minoritized populations; however, there remains a large translational gap in implementing these approaches into federally qualified health centers (FQHC), which serve those at highest risk of HTN-related morbidity and mortality. The paucity of purposeful collaborations between academic researchers and practice staff throughout the research process remains a significant roadblock to the timely translation of evidence to practice.

Design
This commentary describes the key principles and best practices that underlie the development and sustainment of an equitable research-practice alignment, which is supporting the implementation of multilevel systems intervention for improved HTN care in a large FQHC in Brooklyn, New York. The key principles, which are derived from the central tenants of relationship development and maintenance in community-engaged participatory research, patient-centered outcomes research, and organizational alignment theory include (1) cocreation of a shared mental model, (2) bridging multilevel communication, (3) ensuring mutual accountability, and (4) creating a culture of continuous improvement.

Conclusions
Together, the principles guide how the research and practice teams work together to achieve a shared goal of improving the health and well-being of minoritized patients through the provision of high quality, community-oriented HTN care. Best practices to sustain our alignment require an ongoing and deliberate investment in honest and transparent communication by all members.
Community and Healthcare Perspectives on Implementing Hypertension Interventions for a Multiethnic Safety-Net Population
Authors: Sandesara Utpal N. , Carson Savanna L. , Dopp Alex , Perez Lilian G. , Sadia Atkia , Wali Soma , Park Nina J. , Casillas Alejandra , Kim Gloria , Morales Maria G. , Ntekume Ejiro , Song Sarah , Gandhi Priya , Wafford Tony , Brown Arleen F. 
Published: April 2024

Objective
To synthesize community and healthcare informants’ perspectives on contextual considerations and tailoring recommendations for high-quality, sustainable implementation of evidence-based practices (EBPs) for managing hypertension (HTN) in a multiethnic safety-net population.

Design
Structured focus-group discussions and semistructured qualitative interviews.

Background
High-quality, sustainable implementation of HTN-related EBPs can promote equitable care. Implementation challenges extend beyond individual patients to span multiple levels of context. Few studies have systematically engaged community and healthcare perspectives to inform the design of HTN intervention trials.

Setting
A large safety-net healthcare system.

Participants/Methods
We conducted four structured discussions with each of five race- or ethnicity-specific community action boards (CABs) to understand community members’ HTN-related norms, assets, needs, and experiences across local healthcare systems. We interviewed 41 personnel with diverse roles in our partnered healthcare system to understand the system’s HTN-related strengths and needs. We solicited EBP tailoring recommendations from both groups. We summarized the findings using rapid content analysis.

Results
Participants identified contextual considerations spanning seven themes: social determinants, healthcare engagement, clinical interaction, system operations, standardization, patient education, and partnerships and funding. They offered tailoring recommendations spanning nine themes: addressing complex contexts, addressing social needs, system operations, healthcare system training and resources, linguistic and cultural tailoring, behavioral engagement, relational engagement, illness-course engagement, and community partnerships.

Conclusions
Engaging community and healthcare informants can ground implementation in the policy, community, healthcare system, clinical, and interpersonal contexts surrounding diverse patients at risk for disparities. Such grounding can reframe inequitable implementation as a multilevel social problem facing communities and healthcare systems, rather than individuals.
Structure of the Hydrothermal System of Thermal Fields Inferred from Geological-Geophysical Modeling: A Case Study of the Kambalny Volcanic Ridge (Kamchatka)
Authors: Nuzhdaev I.А. , Rychagov S.N. , Feofilaktov S.О. , Bukatov Yu.Yu. 
Published: April 2024

Abstract
––Based on integrated structural and geophysical studies and generalization of geophysical, hydrogeological, mineralogical, geochemical and other data, it is shown that the southern cluster of thermal fields of the Kambalny volcanic ridge (South Kamchatka) is included in the modern hydrothermal system. New data on the structure of the steam hydrotherm discharge area investigated to a depth of about 300 m have been obtained. The structural and hydrodynamic connection between two thermal fields from this group has been established. The Kambalny Ridge geothermal system embracing all major clusters of thermal fields is assumed to have a single deep-seated source of heat supply.
Conditions for Generation, Accumulation, and Preservation of Oil and Gas in Permian Strata, Northwestern Anabar–Khatanga Oil and Gas Region
Authors: Larichev A.I. , Bostrikov O.I. , Khabarov A.N. 
Published: April 2024

Abstract
—Integrated seismic, drilling, and generalizing scientific research in the southeastern Anabar–Khatanga oil and gas region (OGR) since the early 1930s led to discoveries of small oil and gas occurrences and one large Central Olgino oil field. However, the petroleum potential of the northwestern part of the region remains poorly investigated and evaluated. To assess the prospects for the oil and gas potential of this territory, all seismic and geological and geochemical information was used, including four new wells drilled in the Sopochnoe uplift and the Zhuravliny swell. The scales of oil and gas formation, accumulation and destruction of hydrocarbon accumulations in the Permian deposits, which are the most promising in terms of the initial potential of the source rocks included in their composition, is given. The source rocks of the Upper Kozhevnikovo, Lower Kozhevnikovo, and Tustakh formations have been characterized in terms of thickness, contents of organic carbon and chloroform bitumen, maturity (catagenesis) of organic matter, and density of oil migration and gas generation. The maximum possible estimates of oil and gas resources that can potentially accumulate in structural traps, without migration losses, are obtained for each of the three reservoir formations by basin modeling. Judging by geological and geochemical criteria, the Upper Kozhevnikovo Formation can preserve only a minor portion of initially accumulated hydrocarbons, while the oil and gas accumulations, as well as the petroleum generation potential of organic matter in the Lower Kozhevnikovo and Tustakh formations, were destroyed by late Permian–Early Triassic trap magmatism and Mesozoic–Cenozoic tectonic activity.