bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenosquamous Carcinoma Arising in a Mature Cystic Teratoma of the Ovary: A Case Report and Review of the Literature
Authors: Iwaoki Yasuhisa , Katsube Yasuhiro , Toyota Nobutaka 
Published: August 2010

AbstractA 57‐year‐old woman with Stage la adenosquamous carcinoma arising in a mature cystic teratoma was presented. Pathologically, poorly differentiated squamous cell carcinoma and mucoepidermoid carcinoma were intermingled in the solitary nodule inside of the cyst. She received chemotherapy after operation (total abdominal hysterectomy, bilateral salpingo‐oophorectomy, and omentectomy). She is living without evidence of disease 3 years post‐treatment.Adenosquamous carcinoma is a rare malignant component in mature cystic teratomas. We reviewed 7 cases of this cancer arising in mature cystic teratomas, including this case. Three cases with Stage la were living and well for 9 months to 5 years. Three other cases with Stage Ic, II, and IIIc died of their disease at 6, 13 and 2 postoperative months, respectively. These results might suggest that the prognosis of the tumor is worse in advanced stages than that of squamous cell carcinoma in mature cystic teratomas.
Development of an Effective and Simple Insemination Method for the in vitro Fertilization of Patients with Male‐Factor Infertility
Authors: Inagaki Shiro , Suganuma Nobuhiko , Kitagawa Takeshi , Fukugaki Hiroyuki , Nakamur Kiyoshi , Kondo Ikuyo , Tomoda Yutaka 
Published: August 2010

AbstractAn insemination method involving mechanical removal of the cumulus and multiple oocytes per dish (MRC‐MOPD) was applied to achieve in vitro fertilization (IVF) of patients with male‐factor infertility, and the prognosis of IVF and embryo transfer was evaluated. Although the fertilization rate of patients with male‐factor infertility was only 41.4% (12/29) using standard insemination methods, a 73.0% (27/ 37) fertilization rate was achieved with the MRC‐MOPD method. Moreover, 10 patients with male‐factor infertility who were treated with the MRC‐MOPD method achieved clinical pregnancy. A comparison of the results in the 10 patients who were treated with both methods in common reveals that the MRC‐MOPD method also increased the fertilization rate per oocyte. The rate of occurrence of polyploid fertilization did not increase, although large numbers of sperm were inseminated via the MRC‐MOPD method. These results indicate that the MRC‐MOPD method is an effective and simple insemination technique to achieve successful IVF of patients with male‐factor infertility.
The Predictive Value of Extremes of Birth Weight, Mother's Height and Ethnic Origin on the Likelihood of Emergency Caesarean Section
Authors: Hin L.Y. , Khairuddin Y. , Ng K.B. 
Published: August 2010

AbstractWe reviewed the deliveries in a teaching hospital in a multiracial community over the period of one year (1988), and investigated the relationship between maternal height, ethnic origin, and the extremes of birth weight with the likelihood of emergency lower segment caesarean section (LSCS). After excluding patients with obvious indications for LSCS, 5,050 patients were entered in the study. Chi‐square analysis showed that the risk of emergency LSCS is significantly higher in the Indians compared to Chinese and Malays, but does not differ significantly between the latter two groups. Logistic regression analysis showed that birth weight of less than 2,500 g or greater than 3,500 g is the most significant association with emergency LSCS rate. Conditional logistic regression showed that, provided the individuals conformed to the characteristics of the cohort in this study, risk of emergency LSCS for a 150 cm (25th centile) tall Indian pregnant lady is almost twice that of a 158 cm (75th centile) tall non‐Indian.
Causes and Factors Affecting Perinatal Mortality at Princess Basma Teaching Hospital in North Jordan
Authors: Abu‐Heija Adel T. 
Published: August 2010

AbstractThis is the first study about the perinatal mortality in North Jordan. Between 1st June 1991 and 31st May 1992, 8,146 deliveries took place at Princess Basma Teaching Hospital. There were 250 perinatal deaths comprised of 124 stillbirths and 126 early neonatal deaths. The perinatal mortality rate was 30.6 per 1,000. The factors which might have affected this rate were mainly prematurity, low birth weight, unexplained intrauterine fetal death, and congenital malformations. The possible ways of improving the results are discussed.
Effects of Progesterone on the Metabolism of Cancellous Bone in Young Oophorectomized Rats
Authors: Fujimaki T. , Kurabayashi T. , Yamamoto Y. , Yasuda M. , Tojo Y. , Yahata T. , Tanaka K. 
Published: August 2010

AbstractThe effects of progesterone on cancellous bone in young rats were evaluated. Fifty female rats aged 90 days were divided into 5 groups: (1) Sham‐operated controls (SHAM); (2) oophorectomized (OVX) rats; (3) OVX rats treated with estrogen (OVX + E); (4) OVX rats treated with progesterone (OVX + P); and (5) OVX rats treated with estrogen and progesterone (OVX + EP). After surgery, some animals were treated subcutaneously (s.c.) with 0.5 mg of estradiol dipropionate depot, with 5 mg of hydroxyprogesterone capronate depot, or with both hormones, at intervals of 7 days. After 180 days, the bone mineral density (BMD) and bone histomorphometry of their lumbar vertebrae and serological parameters were measured.In the OVX + P group, the BMD and the bone volume as shown by bone histomorphometry were slightly higher than in the OVX group, but not significantly. These parameters in the OVX + E and OVX + EP groups were significantly higher than in the OVX group. The OVX + P group showed a significant increase in the labeled surface and a decrease of the osteoclast number, compared to the OVX group. The OVX + P group showed increases of serum alkarine phosphatase and osteocalcin.From these results, it can be concluded that progesterone treatment might intensify bone formation and suppress bone resorption on cancellous bone in oophorectomized rats, although progesterone alone does not have a positive effect on BMD and bone volume.
A Case of Laparoscopic Complication: Injury of the Left Common Iliac Vessels and Subsequent Acute Compartment Syndrome of the Left Leg
Authors: Honda Tetsuro , Tokushige Makoto , Uda Satoko , Egawa Haruto , Suginami Hiroshi 
Published: August 2010

AbstractA 45‐year‐old Japanese woman underwent a laparoscopy‐assisted vaginal hysterectomy. Insertion of a trocar injured the left common iliac artery and vein, which were repaired within 2.5 hours. Postoperatively the patient presented an acute compartment syndrome of the left leg. Fasciotomy and rehabilitation rescued her from functional disturbances.
Prevention of Pregnancy‐Induced Hypertension by Calcium Dietary Supplement: A Preliminary Report
Authors: Tomoda Shoji , Kitanaka Takashi , Ogita Sachio , Hidaka Atsuo 
Published: August 2010

AbstractObjective: The purpose of this study is to clarify whether the taking of a calcium dietary supplement is able to prevent the development of pregnancy‐induced hypertension (PIH) in Japanese people.Study Design: Forty‐five nulliparous women (Ca‐group) with various high‐risk factors for PIH started to take a calcium supplement (1 g/day in the form of calcium salts) from the 12th gestational week (GW). Obstetrical outcome of Ca‐group was compared to that of the nullipara (n = 453) who did not take a calcium supplement during pregnancy (Non‐Ca Group) and that of the nullipara (n = 413) who did not develop PIH among Non‐Ca group (normotensive group).Results: The incidence of PIH in the Ca‐group was 2.2%, compared to 8.8% of Non‐Ca group. The decrease in blood pressure after taking calcium during the first half of the pregnancy was much greater in Ca‐group than in the normotensive group. The urinary excretion of sodium and calcium and serum free calcium at the 28th GW were much lower in a woman with PIH, despite of the taking of a calcium supplement, than in the normotensive calcium group. Also, the parathyroid hormone level at the 28th GW was higher in the calcium‐taking woman with PIH than in the normotensive calcium group.Conclusion: Our preliminary study suggests that among the possible effects of taking a calcium supplement are a decrease in blood pressure and the prevention of PIH in Japanese people, and that calcium metabolism might be related to the development of PIH. However, more study is needed before it will be possible to reach a final conclusion.
The Possibility of Clinical Application of the Thromboxane A2 Synthase Inhibitor, Ozagrel, for the Treatment and Prevention of Preeclampsia: A Preliminary Report
Authors: Seki Hiroyuki , Kuromaki Ken‐ichi , Takeda Satoru , Kinoshita Katsuyuki , Satoh Kazuo 
Published: August 2010

AbstractObjectives: This study was performed to investigate whether the TXA2 synthase inhibitor, ozagrel, was effective in the treatment and prevention of preeclampsia.Study Design: Ozagrel was administrated therapeutically to 4 severely preeclamptic women, and prophylactically to 5 pregnant women with histories of severe preeclampsia and complications.Results: The therapeutic administration (TA) of ozagrel improved hypertension and proteinuria. Two patients delivered appropriate‐for‐date (AFD) infants, whereas the other 2 patients delivered light‐for‐date (LFD) infants. Mean plasma concentrations of TXB2 (plasma TXB2) decreased, whereas plasma 6‐keto PGF1α were almost unchanged. The prophylactic administration (PA) of ozagrel prevented the occurence of preeclampsia in 3 of the 5 patients. All delivered AFD infants. The duration of pregnancy was prolonged more than that of previous pregnancies in all patients. Plasma TXB2 decreased, whereas plasma 6‐keto PGF1α increased.Conclusions: PA prevented preeclampsia and intrauterine growth retardation, whereas TA improved only maternal symptoms. These results might justify a large prospective study to determine whether ozagrel is an effective prophylactic.
Gestational Herpes: 3 Cases
Authors: Uncu Gürkan , Ozan Hakan , Tathkazan Serhat , Kimya Yalçin , Cengiz Candan 
Published: August 2010

AbstractThree histologically proven gestational herpes cases were presented. All were complaining of itching and vesiculobullous skin lesions. The diagnosis was confirmed by skin biopsies and they all gave a complete response to 1 mg/kg‐day oral prednisolone therapy. No neonatal morbidity was observed.
Dopaminergic System Mediation of Stimulatory Effect of Melatonin on Secretion of Prolactin
Authors: Okada Masataka 
Published: August 2010

AbstractObjective: The purpose of the present study was to clarify the mechanism of the stimulatory effect of melatonin on the secretion of prolactin.Methods: Determination was made of the levels of dopamine (DA), 3,4‐dihydroxyphenylacetic acid (DOPAC), serotonin (5‐HT), and 5‐hydroxyindoleacetic acid (5‐HIAA) in the median eminence of rats following intravenous melatonin (100 μg) administration.Results: Administration of 100μg of melatonin to rats resulted in a significant increase in prolactin secretion (p < 0.01, analysis of variance). Administration of melatonin also resulted in significant decreases in the DOPAC content (p < 0.05) and in the DOPAC/DA ratio (p < 0.05) in the median eminence 1 hour after melatonin administration, at which time serum prolactin was maximal. However, no significant changes were detected in the content of 5‐HT or 5‐HIAA or in the 5‐HIAA/5‐HT ratio in the median eminence.Conclusion: These results suggest that the stimulatory effect of melatonin on the secretion of prolactin might be mediated by dopaminergic mechanisms.
Rapid Chromosome Analysis and Prenatal Diagnosis Using Fluid from the Cystic Hygroma, Hydrothorax and Isolated Ascites: New Source for Chromosome Analysis
Authors: Yang Young Ho , Cho Jae Sung , Min Hae Won , Lee Chang Hoon , Song Chan Ho 
Published: August 2010

AbstractObjective: To determine whether abnormally collected fetal body fluid could be used as alternative cell sources for cytogenetic assessment.Method: Using modified lymphocyte culture, the abnormal fetal body fluids obtained from the five fetal anomaly cases (3 cystic hygromas, 1 hydrothorax, and 1 isolated ascites) were analyzed in order to determine their karyotypes.Results: Two cases showed 45, X and 46, XX/45, X and the other three showed a normal karyotype.Conclusion: The cytogenetic analysis from body fluid aspiration yields a rapid and accurate result within 96 hours. This method could be helpful when cordocentesis or placental biopsy is not feasible or when time requirement for amniotic fluid cell culture is burdensome to patient management.
A New Approach to Methotrexate and Lipiodol Suspensions for Ectopic Pregnancy: Preliminary in vitro and Animal Experiments
Authors: Fujishita Akira , Ishimaru Tadayuki , Masuzaki Hideaki , Matsuwaki Takahiro , Chavez Raul Ortega , Yamabe Tooru , Ogasawara Masayoshi 
Published: August 2010

AbstractObjectives: To measure and evaluate the in vitro release of MTX from suspensions of methotrexate (MTX) and lipiodol (LPD), and to investigate the MTX concentration and fertility rate using an animal model.Methods: This study was divided into three components: a) An in vitro Release Study, b) Animal Study No. 1 (concentration of tissue and plasma levels), and c) Animal Study No. 2 (fertility rate after MTX suspension).Result: The releasing rate in vitro was more rapid with MTX‐S (MTX dissolved in saline) than with either MTX‐LPD (MTX dissolved in lipiodol) or MTX‐LPD‐PC (MTX suspended in lipiodol and phosphatidylcholin, i.e., MTX suspension). The tissue concentration tended to be higher with an MTX suspension than with MTX‐S. There was no significant difference in the fertility rate or the nidation index among the 3 groups (Groups 1, 2, and 3).Conclusion: The injection of an MTX suspension is useful for increasing the tissue concentration and maintaining the long‐term effectiveness of MTX, and this technique might offer a new approach in the treatment of ectopic pregnancy (EP) or in second‐line therapy for persistent EP.
Biochemical Events in Cervical Ripening Dilatation during Pregnancy and Parturition
Authors: Osmers R. G. W. , Adelmann‐Grill B. C. , Rath W. , Stuhlsatz H. W. , Tschesche H. , Kuhn W. 
Published: August 2010

AbstractIn specimens taken from the posterior lip of the cervix uteri we determined the collagenase activity and the glycosaminoglycan concentration. In biopsies obtained from the lower uterine segment during cesarian section we measured cytokines (IL‐ 8, IL‐2, TNFα) and matrix metalloproteinases (MMP‐8, MMP‐9). We found that the release of collagenases is critically involved in the process of cervical dilatation. The glycosaminoglycan concentration increases during pregnancy and shows remarkable changes of the distribution patterns of the different glycosaminoglycans. The parturition is characterized by a dramatic loss of most of the glycosaminoglycans. Furthermore, the IL‐8 shows a close correlation to the clinical feature of cervical ripening and is closely associated with the release of MMP‐8 and MMP‐9.Summarizing the process of cervical maturation and dilatation is a complex enzymatic controlled process with substantial remodelling of the cervical extracellular matrix. The cytokines IL‐8 seems to play an essential role in triggering the process of cervical dilatation.
The Prevention of Mechanical Birth Trauma by Means of Computer Aided Simulation of Delivery by Means of Nuclear Magnetic Resonance Imaging and Finite Element Analysis
Authors: Melchert Frank , Wischnik Arthur , Nalepa Ernst 
Published: August 2010

AbstractAnatomic disproportion gains an increasing interest in obstetrics. Imaging procedures (radiologic pelvimetry, computed or magnetic resonance imaging (MRI) fail to reflect the dynamics of delivery including deformations of the birth channel as well as of fetal structures. To validate findings of imaging procedures in this respect a method has been developed to perform a dynamic, biomechanical postprocessing of the static informations obtained from MRI. Using an especially developped software MRI pixel matrices of maternal pelvis and fetal head were color‐coded and — according to the principle of same density — line data were created. After sectional attribution of the resulting polygones a three‐dimensional mesh of so called Finite elements (FE) was created, which then can be used for deformation analysis. Fetal head was then moved through the birth channel by means of computed simulation. This allows not only ongoing deformations to be visualized but also resulting forces to be calculated for at any time of the delivery process for any point of the anatomical model. Performing these simulations assuming various anatomic and physiologic conditions an obstetrical‐biomechanical data basis could be obtained, that was implemented in a PC‐based expert system. This allows interpretation of pelvimetric data with regard to birth dynamics.
Triple Test for Prenatal Detection of Edwards Syndrome (Trisomy 18)
Authors: Sinosich M. J. , Cameron B. , Robertson R. D. , Saunders D. M. 
Published: August 2010

AbstractObjective(s): To demonstrate the limitation of complete reliance on computer generated interpretations and to highlight the need for understanding of pregnancyrelated biochemistry when offering prenatal screening.Methods: Four cases of cytogenetically confirmed trisomy 18 pregnancies are presented. All four cases underwent prenatal screening (Triple Test‐AFP, uE3, tβ‐hCG) at midgestation and risk assessment by the alpha algorithm.Results: All four cases of trisomy 18 were assessed as being at low risk for DS and/or open NTD. Although marker levels were not consistent with either of these clinical situations, they were indicative of a compromised pregnancy. Circulating levels of trophoblast‐derived antigens (uE3, tβ‐hCG) were depressed ( 0.5 MoM) in all four cases. Further investigations (ultrasonography, amniocentesis) confirmed a trisomy 18 fetus.Conclusions: Risk assessment by computer based algorithms relies on maternal factors and specific DS/NTD marker profiles. Aberrant marker profiles are not distinguished from normal. Therefore, it is essential that prenatal screening is offered only by those competent in pregnancy biochemistry and able to identify these abnormal situations.
Ascitic Positive Cytology and Intraperitoneal Metastasis in Ovarian Dysgerminoma
Authors: Mandai Masaki , Konishi Ikuo , Koshiyama Masafumi , Komatsu Takayuki , Yamamoto Shinichi , Nanbu Kanako , Mori Takahide , Fujii Shingo 
Published: August 2010

AbstractObjectives: To verify the pattern of the spread of tumors in ovarian dysgerminoma, with special reference to intraperitoneal metastasis, and to assess clinicopathologic factors for predicting tumor extension.Methods: Detailed data regarding ascitic cytology, macroscopical findings at surgery, and the histopathology of the surgical specimens were retrospectively reviewed in 12 patients with dysgerminoma who were treated at Kyoto University Hospital. The relationships between the tumor extension and the period of symptoms, the serum lactic dehydrogenase (LDH) level, and the operative findings also were analyzed.Results: Ascitic cytology revealed a high incidence of positivity in 6 of the 10 (60%) cases examined. Extraovarian metastases were present in 4 of the 6 (67%) cases with positive cytology, and in 1 of the 4 (25%) cases with negative cytology. Intraperitoneal metastatic nodules were detected in 5 of the 12 (42%) patients either by inspection during surgery or by postsurgical histological examination. In addition, these metastatic lesions were 5 or fewer in number and 7 mm or less in diameter, except in 1 patient with widespread disease. The presence or absence of extraovarian spread of the tumor was not significantly correlated with the period of symptom, the serum LDH level, the size of the primary tumor, or the volume of the ascitic fluid.Conclusion: The incidence of intraperitoneal spillage and/or metastases of dysgerminoma cells might be higher than previously reported. These findings indicate the importance of ascitic cytology and careful inspection at the time of operation, as well as the rationale of postsurgical chemotherapy for dysgerminoma of an apparently early stage.
Multilocular Peritoneal Inclusion Cysts (Benign Cystic Mesothelioma): A Case Report
Authors: Yaegashi Nobuo , Yajima Akira 
Published: August 2010

AbstractWe report a case of a rare lesion, a multilocular peritoneal inclusion cyst (MPIC), and describe in detail its appearance on MRI. A young woman with pain of the lower abdomen underwent surgical removal of a mass that was histologically diagnosed as an MPIC. The characteristic MRI features were a multilocular cystic mass with thin septa in the pelvic cavity, located both anterior and posterior to the uterus and the adnexa, showing hypointensity of the cyst contents on T1 images and variable hyperintense signals on T2 images.
Assessment of Fetal Health Should Be Based on Maternal Perception of Clusters Rather Than Episodes of Fetal Movements
Authors: Fai Fong Yoke , Singh Kuldip , Malcus Peter , Biswas Arijit , Arulkumaran S. , Ratnam S. S. 
Published: August 2010

AbstractObjective: To determine the level of correlation between mother and machine detected episodes and clusters of fetal movements and their association with fetal heart rate acceleration.Methodology: An observational study conducted on health pregnant women between 29–40 weeks gestation who were admitted in spurious labour to the Department of Obstetrics and Gynaecology, National University Hospital, Republic of Singapore. A continuous record of fetal heart rate and fetal movement was obtained using the fetal actocardiograph. Fetal movements felt by mother were also noted. If a continuous series of fetal movements were perceived over a period of 15 secs on more it was termed clusters of fetal movement. The presence or absence of acceleration in relation to these movements were noted.Results: There was a highly significant correlation between mother and machine in detection of clusters of fetal movements (r = 0.77, p < 0.001); for episodes of fetal movements, the correlation was weaker (r = 0.23, p < 0.05). All clusters of fetal movements perceived by the mother were recorded by the machine and were associated with fetal heart rate accelerations. Two or more accelerations within 3 minutes of the fetal movements were seen with 87.8% of clusters felt by mother compared with 66.7% detected by the machine (p = 0.01). In the 2,263 minutes of recording in 42 women, a cluster of fetal movements was felt at least every 25 minutes by the mother.Conclusion: Maternal perception of 1 or 2 clusters of fetal movements in 30 to 60 minutes may be as reliable as a non‐stress test in reassuring good health. It would be less time consuming than the traditional count to 10 fetal movement chart and a more reliable indicator of fetal health than counting episodes of fetal movements. Thus, our study suggests that clusters rather than episodes of fetal movements should be considered for evaluating fetal health based on fetal movements.