bluuebunny/crossref_metadata_2025_split huggingface dataset:
GPX4 mRNA levels in the polymorphonuclear neutrophils are negatively correlated with autoantibody production, disease activity, and lupus alopecia in systemic lupus erythematosus
Authors: Li Liuying , Yang Fangyuan , Liu Huijuan , Zhang Ruilin , Liang Rongmei , Xu Wenchao , Li Yingfei , Luo Minshuang , Zhai Zeqing , Zhuang Jian , Jie Hongyu , Li Xing , Shi Xingliang , Han Xinai , He Yi , Sun Erwei 
Published: June 2024

AbstractBackgroundFerroptosis is a type of regulated necrosis and glutathione peroxidase 4 (GPX4) has been recognized as a key enzyme that protects against ferroptosis. However, the significance of GPX4 in polymorphonuclear neutrophils (PMNs) of systemic lupus erythematosus (SLE) has not been explored. So we examined GPX4 mRNA in PMNs and analyzed its association with serological and clinical features.MethodsA single center research from the Department of Rheumatology and Immunology of the Third Affiliated Hospital, Southern Medical University was conducted between December 2020 and September 2022. Real‐time transcription‐polymerase chain reaction analysis was used to determine the expression of GPX4 mRNA in PMNs from patients suffering from different rheumatoid immune diseases and healthy controls. The associations of GPX4 RNA levels in SLE patients with serological and clinical indicators were assessed by Spearman's correlation analysis. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic value of GXP4 mRNA for SLE.ResultsGPX4 mRNA levels were lower in SLE patients than those in healthy individuals, patients with rheumatoid arthritis and axial spondyloarthritis. GPX4 mRNA levels were negatively correlated with the number of positive autoantibodies (r = −0.3072, p = 0.0300), anti‐dsDNA antibody (r = −0.3654, p = 0.0336), antinucleosome antibody (r = −0.4052, p = 0.0263), erythrocyte sedimentation rate (r = −0.3773, p = 0.0069), C‐reactive protein (r = −0.4037, p = 0.0036), and SLE disease activity index (r = −0.3072, p = 0.0300). GPX4 mRNA levels were downregulated in patients with alopecia compared with patients without alopecia (p < 0.05). The diagnostic capacity of GPX4 mRNA achieved high diagnostic accuracy (area under the curve = 0.848) with sensitivity (78.00%) and specificity (80.95%).ConclusionDownregulated GPX4 mRNA in PMNs of SLE patients is negatively associated with the production of antinuclear antibodies, disease activity, and lupus alopecia, suggesting an important role of ferroptosis in SLE, high diagnostic value of GPX4 mRNA in PMNs, and potential therapies targeting GPX4 for SLE patients, especially lupus alopecia.
From text to model: Leveraging natural language processing for system dynamics model development
Authors: Veldhuis Guido A. , Blok Dominique , de Boer Maaike H.T. , Kalkman Gino J. , Bakker Roos M. , van Waas Rob P.M. 
Published: June 2024

AbstractTextual data is abundantly available, and natural language processing (NLP) facilitates its analysis. However, system dynamics (SD) modelling relies on the modeller to identify relevant information. We explore the ability of NLP models to support SD modelling by identifying causal sentences in texts. We provide a primer on the notion of causality in SD and on the linguistic properties of causality, followed by an introduction of NLP models suitable for this task. Using three test cases, we evaluate the performance of the NLP models using common evaluation metrics and an SD model completeness metric. We conclude that NLP models can add considerable value to SD modelling, provided that remaining challenges are addressed. One such caveat is the difference we observe between information regarded as causal and information relevant for describing system structure. We discuss how these challenges can be addressed through collaboration between the NLP and SD fields. © 2024 The Author(s). System Dynamics Review published by John Wiley & Sons Ltd on behalf of System Dynamics Society.
Annular Elastolytic Giant Cell Granuloma Associated with Autoimmune Hepatitis: Response to Ciclosporin
Authors: Sharif Zaina , Javadzadeh Shagayegh , Boissiere Jeanne , Creamer Daniel 
Published: June 2024

Abstract
A 47 year old Caucasian female with a background of type 2 diabetes mellitus, hypothyroidism, and autoimmune hepatitis presented with a painful, pruritic, papular eruption in a photosensitive distribution across the upper chest, neck, face, dorsal hands and forearms. On examination, lesions coalesced into annular plaques each with an active, raised margin and an atrophic, yellow centre. Histopathology demonstrated an absence of mucin and elastophagocytosis with giant cells engulfing dermal elastin fibres. These histopathological features favoured a diagnosis of annular elastolytic giant cell granuloma (AEGCG). The patient was managed ciclosporin monotherapy 125 mg twice daily (3 mg/kg/day). At 8 week review, there was a marked improvement in the physical appearance of the dermatosis as well as diminishing of symptoms such as itch and cutaneous pain. AEGCG is a rare inflammatory dermatosis typically affecting sun-exposed sites. It has been proposed that AEGCG is triggered by a solar induced elastolysis however other theories suggest it is a primary granulomatous disorder and not a photodermatosis. AEGCG appears to be aligned to an autoimmune diathesis, indicated by its frequent association with autoimmune conditions such as Hashimoto’s thyroiditis, vitiligo, giant cell arteritis and, as in our patient, auto-immune hepatitis. Diabetes mellitus occurring concurrently with AEGCG has also been observed, again like our patient. Histopathological features which distinguish AEGCG from granuloma annulare include absent mucin, absent necrobiosis, giant cells with more nuclei, non-palisading granulomata and marked loss of elastic tissue. AEGCG is often unresponsive to standard therapies. The literature indicates varying responses to photo-protection, topical/systemic/intralesional corticosteroids, and oral medications such as methotrexate, hydroxychloroquine, and dapsone. Few case reports have also documented improvement with ciclosporin. In aggressive forms of AEGCG, as in our patient, treatment with ciclosporin may be an effective intervention and should be initiated early in the disease.
Unidirectional Transmission Metasurfaces with Topological Continuity Generated from High‐dimensional Design Space
Authors: Deng Miaoyi , Yu Ying , Cao Guowei , Feng Junbo , Zhu Xing , Li Yu 
Published: June 2024

AbstractWith the growing demand for nanodevices, there is a concerted effort to improve the design flexibility of nanostructures, thereby expanding the capabilities of nanophotonic devices. In this work, a Laplacian‐weighted binary search (LBS) algorithm is proposed to generate a unidirectional transmission metasurface from a high‐dimensional design space, offering an increased degree of design freedom. The LBS algorithm incorporates topological continuity based on the Laplacian, effectively circumventing the common issue of high structural complexity in designing high‐dimensional nanostructures. As a result, metasurfaces developed using the LBS algorithm in a high‐dimensional design space exhibit reduced complexity, which is advantageous for experimental fabrication. An all‐dielectric metasurface with unidirectional transmission, designed from the high‐dimensional space using the LBS method, demonstrated the successful application of these design principles in experiments. The metasurface exhibits high optical performance on unidirectional transmission in measurements by a high‐resolution angle‐resolved micro‐spectra system, achieving forward transmissivity above 90% (400–700 nm) and back transmissivity below 20% (400–500 nm) within the targeted wavelength range. This work provides a feasible approach for advancing high‐dimensional metasurface applications, as the LBS design method takes into account topological continuity during experimental processing. Compared to traditional direct binary search (DBS) methods, the LBS method not only improves information processing efficiency but also maintains the topological continuity of structures. Beyond unidirectional transmission, the LBS‐based design method has generality and flexibility to accommodate almost all physical scenarios in metasurface design, enabling a multitude of complex functions and applications.
A survey of the state‐of‐the‐art approaches for evaluating trust in software ecosystems
Authors: Hou Fang , Jansen Slinger 
Published: June 2024

AbstractThird‐party software has streamlined the software engineering process, allowed software engineers to focus on developing more advanced components, and reduced time and cost. This shift has led to software development strategies moving from competition to collaboration, resulting in the concept of software ecosystems, in which internal and external actors work together on shared platforms and place their trust in the ecosystem. However, the increase in shared components has also created challenges, especially in security, as the large dependency trees significantly enlarge a system's attack surface. The situation is made worse by the lack of effective ways to measure and ensure the trustworthiness of these components. In this article, we explore current approaches used to evaluate trust in software ecosystems, focusing on analyzing the specific techniques utilized, the primary factors in trust evaluation, the diverse formats for result presentation, as well as the software ecosystem entities considered in the approaches. Our goal is to provide the status of current trust evaluation approaches, including their limitations. We identify key challenges, including the limited coverage of software ecosystem entities; the objectivity, universality, and environmental impacts of the evaluation approaches; the risk assessment for the evaluation approaches; and the security attacks posed by trust evaluation in these approaches.
Biomass Derived Biofluorescent Carbon Dots for Energy Applications: Current Progress and Prospects
Authors: Ayisha Naziba T. , Praveen Kumar D. , Karthikeyan S. , Sriramajayam S. , Djanaguiraman M. , Sundaram Senthilarasu , Ghamari Mehrdad , Prasada Rao R. , Ramakrishna Seeram , Ramesh D. 
Published: June 2024

AbstractBiomass resources are often disposed of inefficiently and it causes environmental degradation. These wastes can be turned into bio‐products using effective conversion techniques. The synthesis of high‐value bio‐products from biomass adheres to the principles of a sustainable circular economy in a variety of industries, including agriculture. Recently, fluorescent carbon dots (C‐dots) derived from biowastes have emerged as a breakthrough in the field, showcasing outstanding fluorescence properties and biocompatibility. The C‐dots exhibit unique quantum confinement properties due to their small size, contributing to their exceptional fluorescence. The significance of their fluorescent properties lies in their versatile applications, particularly in bio‐imaging and energy devices. Their rapid and straight‐forward production using green/chemical precursors has further accelerated their adoption in diverse applications. The use of green precursors for C‐dot not only addresses the biomass disposal issue through a scientific approach, but also establishes a path for a circular economy. This approach not only minimizes biowaste, which also harnesses the potential of fluorescent C‐dots to contribute to sustainable practices in agriculture. This review explores recent developments and challenges in synthesizing high‐quality C‐dots from agro‐residues, shedding light on their crucial role in advancing technologies for a cleaner and more sustainable future.
Pulmonary coinfection by Pneumocystis jirovecii and Aspergillus terreus in an ITP patient after corticosteroid therapy: A case report
Authors: Wang Lili , Wang Fengling , Mao Enqiang , Chen Erzhen , Chen Dayu , Wang Linyu , Qiu Yusi , Bian Xiaolan , Li Yan , He Juan 
Published: June 2024

AbstractPneumocystis jirovecii pneumonia and invasive pulmonary aspergillosis are both life‐threatening opportunistic fungal infections. There are only few reports of coinfection by these two fungi in the literature, and Aspergillus fumigatus is the predominant Aspergillus species in the coinfection. We report here the first case of coinfection by Aspergillus terreus and P. jirovecii pneumonia and caspofungin can be an appropriate choice for salvage treatment of the coinfection. A 51‐year‐old man with a history of immune thrombocytopenia treated with prednisone over 2 months was admitted to emergency intensive care unit for acute respiratory failure and a cavity was found on chest computed tomography. Therefore, his trachea was immediately intubated. The patient was treated with a large spectrum of antibiotic regimen, consisting initially of imipenem/cilastatin, moxifloxacin and fluconazole followed by fluconazole, imipenem/cilastatin, vancomycin, trimethoprim–sulphamethoxazole (TMP‐SMZ) and azithromycin. When the polymerase chain reaction analysis of the bronchoalveolar lavage sample revealed P. jirovecii and A. terreus, all the antibiotics were stopped except TMP‐SMZ, and voriconazole was added. Two weeks later, the patient showed clinical improvement but radiological deterioration. Consequently, caspofungin was started for salvage therapy, then the patient showed gradual clinical improvement. He was discharged with oral voriconazole and TMP‐SMZ. The antifungal treatment was continued for 6 months until complete radiological absorption. In conclusion, early bronchoscopy with bronchoalveolar lavage fluid should be considered in order to diagnose and treat promptly in those treated with corticosteroids combined with immunocompromised and caspofungin could be an appropriate choice for salvage treatment of coinfection by P. jirovecii and A. terreus.
An update of the development of motor behavior
Authors: Franchak John M. , Adolph Karen E. 
Published: June 2024

AbstractThis primer describes research on the development of motor behavior. We focus on infancy when basic action systems are acquired—posture, locomotion, manual actions, and facial actions—and we adopt a developmental systems perspective to understand the causes and consequences of developmental change. Experience facilitates improvements in motor behavior and infants accumulate immense amounts of varied everyday experience with all the basic action systems. At every point in development, perception guides behavior by providing feedback about the results of just prior movements and information about what to do next. Across development, new motor behaviors provide new inputs for perception. Thus, motor development opens up new opportunities for acquiring knowledge and acting on the world, instigating cascades of developmental changes in perceptual, cognitive, and social domains.This article is categorized under:
Cognitive Biology > Cognitive Development
Psychology > Motor Skill and Performance
Neuroscience > Development
Introduction
Authors: Ibričević Aida 
Published: June 2024

Abstract“I want to go home,” a highly successful documentary series started broadcasting on various Bosnian TV channels in May 2016. The documentary program (Kenović, 2016) features the stories of artists, entrepreneurs, scientists, academics, and other professionals who have built their careers abroad and have now returned “home” to Bosnia and Herzegovina (BiH). Scenes of harmonious family life filled with homemade food and drink, breathtaking images of natural landscapes, and the nostalgic sounds of sevdah music are interwoven with the returnees telling their life stories. In the interviews, the participants acknowledge the benefits of greater career opportunities, economic advantages, democratic freedoms, and political stability of living in the West. However, almost every interviewee emphasized how they feel more content as citizens in their country of origin; how they belong there and how they are socially and spiritually more fulfilled in their home environment. The returnees often invoked well-known phrases such as “There’s no place like home,” “Home is where the heart is,” “Home sweet home” or a Bosnian-Croatian-Serbian saying that goes something like “Travel the world, but keep coming back home.” Such expressions seem to have universal appeal, often found dutifully embroidered on handcrafted ornaments stitching together an amalgamation of warmth and comfort. Yet, their direct application to a context of forced migration and displacement, where some returnees were victims of violence, mass expulsions, ethnic cleansing campaigns, and other forms of persecution, while others have endured considerable sacrifices to make their return a reality, seems to be highly questionable. The documentary series also appears to be in line with international community efforts towards diaspora engagement. Countless “diaspora business forums,” networking events and roundtables are being organized by various levels of government to attract investment from members of the BiH diaspora. Faced with a dwindling tax base, because of high unemployment and emigration rates, the BiH authorities are trying to lure the desperately needed investment for job creation. The returnees’ warm and “homely” responses were accepted and not questioned or problematized by the filmmakers, leading me to believe that the popular TV program was made to promote return and not present a more nuanced understanding of it. Unabated by the often overly sentimentalized, and at times saccharine portrayals of warm homecomings, and with my researcher curiosity piqued, I set out to investigate the phenomenon with scholarly rigor and present my findings in this book.
Losing, Creating and Re-creating Home and Belonging
Authors: Ibričević Aida 
Published: June 2024

AbstractSo far, geography scholars have theorized the emotional dimension of citizenship as home and belonging, while relevant scholarly literature treats both concepts as complex and multi-dimensional. This chapter aims to contribute to this literature by exploring the returnees’ understanding of home and belonging. The life experience of my study participants makes this exploration particularly interesting, as its simplified version includes at least three phases: the initial loss of home in BiH, followed by an effort at homemaking in the host state, and ending with an attempt to re-create their home upon return. Along these three stages, the returnees experience various types of belonging, exclusion from belonging both at home and abroad, as well as in-betweenness and multiple belonging. Throughout the process of loss, building and re-building of home and the associated types of belonging, the returnees experience specific emotions, which create links to the overarching concept of emotional citizenship. Expressly, this chapter answers the research questions: What do ‘home’ and ‘belonging’ mean to the returnees? What do they associate these concepts with? Which specific emotions do they convey?
Gut microbiome shifts in people with type 1 diabetes are associated with glycaemic control: an INNODIA study
Authors: Vatanen Tommi , de Beaufort Carine , Marcovecchio M. Loredana , Overbergh Lut , Brunak Soren , Peakman Mark , Mathieu Chantal , Knip Mikael ,   on behalf of the INNODIA consortium
Published: June 2024

Abstract
Aims/hypothesis
The gut microbiome is implicated in the disease process leading to clinical type 1 diabetes, but less is known about potential changes in the gut microbiome after the diagnosis of type 1 diabetes and implications in glucose homeostasis. We aimed to analyse potential associations between the gut microbiome composition and clinical and laboratory data during a 2 year follow-up of people with newly diagnosed type 1 diabetes, recruited to the Innovative approaches to understanding and arresting type 1 diabetes (INNODIA) study. In addition, we analysed the microbiome composition in initially unaffected family members, who progressed to clinical type 1 diabetes during or after their follow-up for 4 years.

Methods
We characterised the gut microbiome composition of 98 individuals with newly diagnosed type 1 diabetes (ND cohort) and 194 autoantibody-positive unaffected family members (UFM cohort), representing a subgroup of the INNODIA Natural History Study, using metagenomic sequencing. Participants from the ND cohort attended study visits within 6 weeks from the diagnosis and 3, 6, 12 and 24 months later for stool sample collection and laboratory tests (HbA1c, C-peptide, diabetes-associated autoantibodies). Participants from the UFM cohort were assessed at baseline and 6, 12, 18, 24 and 36 months later.

Results
We observed a longitudinal increase in 21 bacterial species in the ND cohort but not in the UFM cohort. The relative abundance of Faecalibacterium prausnitzii was inversely associated with the HbA1c levels at diagnosis (p=0.0019). The rate of the subsequent disease progression in the ND cohort, as assessed by change in HbA1c, C-peptide levels and insulin dose, was associated with the abundance of several bacterial species. Individuals with rapid decrease in C-peptide levels in the ND cohort had the lowest gut microbiome diversity. Nineteen individuals who were diagnosed with type 1 diabetes in the UFM cohort had increased abundance of Sutterella sp. KLE1602 compared with the undiagnosed UFM individuals (p=1.2 × 10−4).

Conclusions/interpretation
Our data revealed associations between the gut microbiome composition and the disease progression in individuals with recent-onset type 1 diabetes. Future mechanistic studies as well as animal studies and human trials are needed to further validate the significance and causality of these associations.

Graphical Abstract
A review of automated cutting tool selection methods
Authors: Navaneethan Gowthri , Palanisamy Suresh , Jayaraman Prem Prakash , Kang Yong-Bin , Stephens Guy , Papageorgiou Angelo , Navarro John 
Published: June 2024

AbstractThe selection of appropriate cutting tool (CT) is a critical part of machining. Selecting the right tool for the right job will enable customers to achieve economic machining, saving time and cost while delivering high-quality products. Nowadays, the complexity of CT and workpiece is increasing; this changes the input and output requirements for cutting tool selection paving way to automation. There are two types of CT selection methods, manual and automated CT selection. This article focuses on automated CT selection, which has different inputs and outputs based on the algorithm/AI technique used. The potential and promising aspects of CT selection could enhance the machining in terms of productivity, time, cost, and quality aspects. A comprehensive review of automated CT selection methods has been presented in this paper. The review surveys different automated CT selection methods in terms of inputs, outputs, and artificial intelligence (AI) techniques/different algorithms since most of the researchers have not focused on this perspective. It outlines the current status of research and application, which has the potential to improve the automated CT selection methods for the benefit of the manufacturing industry.