Spatiotemporal transmission of SARS-CoV-2 lineages during 2020–2021 in Pernambuco—Brazil
Authors: Machado Lais Ceschini , Dezordi Filipe Zimmer , de Lima Gustavo Barbosa , de Lima Raul Emídio , Silva Lilian Caroliny Amorim , Pereira Leandro de Mattos , da Silva Alexandre Freitas , Silva Neto Antonio Marinho da , Oliveira André Luiz Sá de , Armstrong Anderson da Costa , Pessoa-e-Silva Rômulo , Loyo Rodrigo Moraes , Silva Barbara de Oliveira , de Almeida Anderson Rodrigues , da Rocha Pitta Maira Galdino , Santos Francisco de Assis da Silva , Mendonça Siqueira Marilda , Resende Paola Cristina , Delatorre Edson , Naveca Felipe Gomes , Miyajima Fabio , Gräf Tiago , do Carmo Rodrigo Feliciano , Pereira Michelly Cristiny , Campos Tulio de Lima , Bezerra Matheus Filgueira , Paiva Marcelo Henrique Santos , Wallau Gabriel da Luz ,   On behalf of Fiocruz COVID-19 Genomic Network
Published: April 2024

ABSTRACT

SARS-CoV-2 virus emerged as a new threat to humans and spread around the world, leaving a large death toll. As of January 2023, Brazil is among the countries with the highest number of registered deaths. Nonpharmacological and pharmacological interventions have been heterogeneously implemented in the country, which, associated with large socioeconomic differences between the country regions, has led to distinct virus spread dynamics. Here, we investigate the spatiotemporal dispersion of SARS-CoV-2 lineages in the Pernambuco state (Northeast Brazil) throughout the distinct epidemiological scenarios that unfolded in the first 2 years of the pandemic. We generated a total of 1,389 new SARS-CoV-2 genomes from June 2020 to August 2021. This sampling captured the arrival, communitary transmission, and the circulation of the B1.1, B.1.1.28, and B.1.1.33 lineages; the emergence of the former variant of interest P.2; and the emergence and fast replacement of all previous variants by the more transmissible variant of concern P.1 (Gamma). Based on the incidence and lineage spread pattern, we observed an East-to-West to inner state pattern of transmission, which is in agreement with the transmission of more populous metropolitan areas to medium- and small-size country-side cities in the state. Such transmission patterns may be partially explained by the main routes of traffic across municipalities in the state. Our results highlight that the fine-grained intrastate analysis of lineages and incidence spread can provide actionable insights for planning future nonpharmacological intervention for air-borne transmissible human pathogens.

IMPORTANCE
During the COVID-19 pandemic, Brazil was one of the most affected countries, mainly due its continental-size, socioeconomic differences among regions, and heterogeneous implementation of intervention methods. In order to investigate SARS-CoV-2 dynamics in the state of Pernambuco, we conducted a spatiotemporal dispersion study, covering the period from June 2020 to August 2021, to comprehend the dynamics of viral transmission during the first 2 years of the pandemic. Throughout this study, we were able to track three significant epidemiological waves of transmission caused by B1.1, B.1.1.28, B.1.1.33, P.2, and P.1 lineages. These analyses provided valuable insights into the evolution of the epidemiological landscape, contributing to a deeper understanding of the dynamics of virus transmission during the early years of the pandemic in the state of Pernambuco.