bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of Cancer Survivors' Receptivity to Lifestyle Behavior Change Interventions
Authors: K Basen-Engquist , C Carmack , J Blalock , G Baum , W Rahming , W Demark-Wahnefried 
Published: March 2012

Abstract
Purpose: To assess cancer survivors' interest in lifestyle behavior change interventions, and to identify predictors of interest.
Methods: Mailed surveys were sent to a stratified random sample of breast, colorectal, and prostate cancer survivors ascertained from the MD Anderson tumor registry and departmental databases. Surveys queried survivors about their diet, exercise, and smoking behaviors; symptoms; and their interest in interventions.
Results: Surveys were received from 1053 cancer survivors. Roughly half of the sample were very/extremely interested in programs to help them get in shape (45%), eat a healthy diet (54%), and control weight (49%), and 20% had no interest at all. Because they were highly intercorrelated we combined interest in diet/exercise/weight control into a single interest index. Interest was related to race/ethnicity (AA and Hispanics more interested than whites), age (p = .000, younger more interested), marital status (p = .000, divorced most interested, widowed least interested), education (p = .008, college-educated less interested than those with HS degree or some college/vocational training), and gender (p = .000; women more interested). Interest was not related to time from diagnosis, and there were no differences by cancer site after controlling for gender. BMI had a small but significant correlation with interest in programs (r = .19, p = .000; the correlation was higher in women [r = .24] than men [r = .18]). Symptom severity and interference, and feelings of distress and sadness, were positively correlated to interest (r = .07–.12, p = .000–.034); relationships were stronger among men than women. Among the 78 smokers, 51% were very/extremely interested in smoking cessation, while 20% were not at all interested. Demographic and disease-related predictors were not significantly related to interest in smoking cessation, but symptom severity and interference, and feelings of sadness were positively related to interest.
Conclusion: Survivors' interest in lifestyle behavior change interventions varies with demographic variables, but also with symptom distress. Experiencing symptoms after cancer diagnosis is related to higher receptivity to intervention opportunities.
Deficits in Health-Promoting Behaviors Among Veteran and Non-Veteran Male Cancer Survivors in Texas
Authors: M Kowalkowski , H Goltz , D Latini 
Published: March 2012

Abstract
Objectives: Cancer survivors may have increased risk for additional malignancies and illnesses. Veterans comprise a significant proportion of Texas male cancer survivors and may differ in their health status and needs from non-veterans. It is unknown whether they differ in general health-promotion strategies. This study sought to identify deficits in health-promoting behaviors among Texas male cancer survivors and to determine whether veteran-status predicts differences along these behaviors.
Methods: Using the Behavioral Risk Factor Surveillance System 2009 survey, we conducted secondary analysis of 280 veteran and 250 non-veteran Texas male cancer survivors. Data were analyzed using Fisher's exact test and logistic-regression models.
Results: Survivors averaged 68 years (SD = 11.4) and were primarily white (93%), married (71.5%), college graduates (51%), and non-smokers (91%). Respondents reported several different cancer diagnoses; most commonly prostate (28%). More non-veterans than veterans were obese (31.6% vs. 22.5%; p = 0.03). Veteran-status was not associated with other co-morbidities, current smoking, binge drinking, or fruit/vegetable consumption. However, only 22% met recommendations for daily fruits/vegetables. In multivariate regression, veterans were less likely to meet moderate (OR = 0.54, 95% CI = 0.30–0.95) and vigorous (OR = 0.67, 95% CI = 0.45–0.99) physical-activity recommendations, but were more likely to have had health examinations within the previous year (OR = 1.77, 95% CI = 1.11–2.83).
Conclusion: Texas male cancer survivors reported deficits across important health behaviors, including dietary and physical-activity recommendations. Veterans reported low compliance with physical-activity guidelines, in spite of evidence-based veterans health-promotion programs, e.g., MOVE! ®. Our results suggest veterans' adherence to routine care may offer a point of intervention to implement health-promotion guidelines among cancer survivors. Further research is needed to understand how to use the growing focus on cancer survivorship within the VA healthcare system to encourage greater adoption of health promotion practices among veteran cancer survivors.
Relationship Between Use of Different Oral Contraceptive Formulations and Breast Cancer Risk Among Young Women
Authors: E Beaber , D Buist , W Barlow , K Malone , S Reed , C Li 
Published: March 2012

Abstract
Purpose: Prior studies suggest that recent oral contraceptive (OC) use is associated with a modest increased risk of breast cancer among young women. However, the majority of these reports have relied on self-reported use and have not characterized risks associated with newer OC formulations.
Methods: We conducted a nested case-control study among health plan enrollees at a large health maintenance organization, Group Health Cooperative, which serves the greater Seattle-Puget Sound region. Cases consisted of 1,102 women 20–49 years of age diagnosed with invasive breast cancer from 1990–2009. We randomly selected 21,952 controls matched on age, year, and enrollment length. Detailed information on recent OC use, including formulation, dose, and duration was ascertained from electronic pharmacy records. Multivariate-adjusted conditional logistic regression was used to calculate odds ratios (ORs) as estimates of relative risks and 95% confidence intervals (CIs).
Results: Recent OC use (within 1 year of diagnosis) was associated with a 60% (95% CI = 1.3–1.9) increased breast cancer risk. The association was slightly stronger for estrogen receptor (ER) positive compared to ER-negative disease (ER-positive OR = 1.7, 95% CI = 1.3–2.1 and ER-negative OR = 1.2, 95% CI = 0.8–1.8), though this difference was not statistically significant. The ORs varied somewhat by OC formulation, with recent use of OCs containing the progestin ethynodiol diacetate (OR = 2.6, 95% CI = 1.4–4.7) or high dose estrogen (OR = 2.7, 95% CI = 1.2–6.4) associated with particularly elevated risk estimates compared to non-use of OCs in the prior year. In contrast, risk estimates for recent use of OCs with the progestin norgestimate or low dose estrogen suggested either a modest association or no association (OR = 1.2, 95% CI = 0.6–2.2 and OR = 1.0, 95% CI = 0.6–1.7, respectively).
Conclusions: These results suggest that recent use of contemporary OC formulations is associated with an elevated risk of breast cancer among women ages 20–49, with associations varying somewhat by OC formulation. Although breast cancer is rare among young women, the potential risk of breast cancer associated with certain formulations could impact OC recommendations by providers if these findings are confirmed.
Research Addressing Follow-Up for Abnormal Cancer Screening Tests: NCI Portfolio Analyses
Authors: J Zapka , H Edwards , V Chollette , S Taplin 
Published: March 2012

Abstract
Purpose: The study's purposes were to identify the portfolio of grants awarded by the National Cancer Institute that addressed follow-up to abnormal screening tests for colon, breast and cervical cancer, document key research design characteristics, and discuss questions and issues for future practice and research.
Methods: A standardized form was used to audit grants funded from 2002 through 2011. Grant text was independently reviewed by two auditors; differences in reports were discussed until consensus was reached. The investigators then summarized findings in order to distill trends and issues.
Results: Twelve grants met inclusion criteria; 5, 4, 2 and 1 addressed follow-up of Pap tests, mammography, and colorectal tests and multiple screens respectively. Fifty percent were R01 awards, the majority of which applied group or individual RCT designs. One was a prospective cohort study. R21s typically emphasized qualitative methods and stressed behavioral epidemiology, measurement tool development and intervention planning; several listed aims related to determining prevalence. Definition of outcome measures was variable: e.g. completion of a follow-up test; time to follow-up; and steps until diagnosis. Four studies explicitly focused on ethnic/racial disparities; 5 on low income and underserved populations. Several emphasized measurement development. Three included cost analyses research questions. Most focused on individual level change, although changes in the broader multi-level context were proposed, but at times implicit, often viewed as process measures. A majority included aims related to understanding important mediator and moderator variables. Few explicated multilevel theories, although models reflected an ecological orientation.
Conclusions: Future practice and research priorities include development of clear operational definitions of follow-up; conceptual and descriptive evaluations of how providers, patients, and organizations interact across the steps and interfaces of follow-up care; determination of priorities for multilevel intervention testing and improvement of measures, and application of appropriate and innovative study designs using multi-methods.
This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E.
Modelling and simulation of edoxaban exposure and response relationships in patients with atrial fibrillation
Authors: Mendell Jeanne , Kastrissios Helen , Green Michelle , Carrothers Timothy J. , Song SaeHeum , Patel Indravadan , Antman Elliott M. , Giugliano Robert P. , Kunitada Satoshi , Dornseif Bruce , Shi Minggao , Tachibana Masaya , Zhou Simon , Rohatagi Shashank , Salazar Daniel E. , Bocanegra Tomas S. 
Published: March 2012

SummaryEdoxaban is a novel, orally available, highly specific direct inhibitor of factor Xa and is currently being developed for the treatment and prevention of venous thromboembolism and prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF). The objectives of the present analyses were to characterise edoxaban population pharmacokinetics (PPK) and identify potential intrinsic and extrinsic factors affecting variability in edoxaban exposure, determine if there are relationships between edoxaban pharmacokinetics or biomarkers and the risk of bleeding in patients with NVAF using an exposure-response model, and to use the PPK and exposure-response model to support dose selection for a phase III trial of edoxaban in patients with NVAF. PPK analysis of data from 1,281 edoxaban-dosed subjects with intrinsic factors such as renal impairment or NVAF and extrinsic factors such as concomitant medications revealed significant effects of renal impairment and concomitant strong P-glycoprotein (P-gp) inhibitors on the pharmacokinetics of edoxaban. Exposure-response analysis found that in patients with NVAF, the incidence of bleeding events increased significantly with increasing edoxaban exposure, with steady-state minimum concentration (Cmin,ss) showing the strongest association. Clinical trial simulations of bleeding incidence were used to select 30 mg and 60 mg once-daily edoxaban with 50% dose reductions for patients with moderate renal impairment or receiving concomitant strong P-gp inhibitors as the treatment regimens in the ENGAGE AF-TIMI 48 (NCT00781391) trial.The results of this study were previously presented at the 2009 International Society on Thrombosis and Haemostasis, July 2009, Boston, Massachusetts, USA.
Immunosuppressive function of mesenchymal stem cells from human umbilical cord matrix in immune thrombocytopenia patients
Authors: Ma Li , Zhou Zeping , Zhang Donglei , Yang Shaoguang , Wang Jinhong , Xue Feng , Yang Yanhui , Yang Renchi 
Published: March 2012

SummaryHuman umbilical cord matrix/Wharton's Jelly (hUC)-derived mesenchymal stem cells (MSC) have been shown to have marked therapeutic effects in a number of inflammatory diseases and autoimmune diseases in humans based on their potential for immunosuppression and their low immunogenicity. Currently, no data are available on the effectiveness of UC-MSC transplantation in immune thrombocytopenia (ITP) patients. It was the objective of this study to assess the effect of allogeneic UC-MSCs on ITP patients in vitro and in vivo. Peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BM-MNCs) from ITP patients and healthy controls were co-cultured with UC-MSCs for three days and seven days, respectively. Flow cytometry and ELISA were applied to assess the various parameters. In PBMCs from ITP patients, the proliferation of autoreactive T, B lymphocytes and destruction of autologous platelets were dramatically suppressed by UC-MSCs. UC-MSCs not only suppressed co-stimulatory molecules CD80, CD40L and FasL expression but also in shifting Th1/Th2/Treg cytokines profile in ITP patients. UC-MSCs obviously reversed the dysfunctions of megakaryocytes by promoting platelet production and decreasing the number of living megakaryocytes as well as early apoptosis. In addition, the level of thrombopoietin was increased significantly. Our clinical study showed that UC-MSCs play a role in alleviating refractory ITP by increasing platelet numbers. These findings suggested that UC-MSCs transplantation might be a potential therapy for ITP.
Early Detection of an Underperforming Implantable Cardiovascular Device Using an Automated Safety Surveillance Tool
Authors: Hauser Robert G. , Mugglin Andrew S. , Friedman Paul A. , Kramer Daniel B. , Kallinen Linda , McGriff Deepa , Hayes David L. 
Published: March 2012

Background—
Postmarket medical device surveillance in the United States depends largely on voluntary reporting of adverse events. Consequently, early safety signals may be missed, exposing patients to potentially hazardous products. The aim of this study was to assess the feasibility of using an automated safety surveillance tool to detect early signals that a marketed implantable cardiac device was underperforming.

Methods and Results—
For this purpose, we performed simulated prospective monthly full-cohort and propensity-matched comparative survival analyses on our 3-center database of Sprint Fidelis and Quattro Secure implantable cardioverter-defibrillator leads, using a commercially available automated surveillance tool that was preset to trigger an alert if the log rank probability value was <0.05. During the study, 84 of 1035 Fidelis (8.1%) and 23 of 1675 Quattro (1.4%) leads failed. The simulated full-cohort analysis triggered a sustained alert for Fidelis leads beginning 13 months after the first implant and 2 years before Fidelis leads were removed from the market. Of the 1035 patients who had Fidelis leads, up to 969 (93.6%) were successfully matched to Quattro patients. In the propensity-matched analysis, the alert triggered 22 months after the first Fidelis implant and more than 1 year before the lead was recalled.

Conclusions—
An active automated safety surveillance system could have identified this implantable cardiovascular device problem substantially sooner than was achieved through existing postmarket surveillance methods. Such a tool, when applied to clinical registries and remote monitoring databases, may limit the exposure of large populations to underperforming and potentially hazardous cardiovascular devices.
Addition of Frailty and Disability to Cardiac Surgery Risk Scores Identifies Elderly Patients at High Risk of Mortality or Major Morbidity
Authors: Afilalo Jonathan , Mottillo Salvatore , Eisenberg Mark J. , Alexander Karen P. , Noiseux Nicolas , Perrault Louis P. , Morin Jean-Francois , Langlois Yves , Ohayon Samuel M. , Monette Johanne , Boivin Jean-Francois , Shahian David M. , Bergman Howard 
Published: March 2012

Background—
Cardiac surgery risk scores perform poorly in elderly patients, in part because they do not take into account frailty and disability which are critical determinants of health status with advanced age. There is an unmet need to combine established cardiac surgery risk scores with measures of frailty and disability to provide a more complete model for risk prediction in elderly patients undergoing cardiac surgery.

Methods and Results—
This was a prospective, multicenter cohort study of elderly patients (≥70 years) undergoing coronary artery bypass and/or valve surgery in the United States and Canada. Four different frailty scales, 3 disability scales, and 5 cardiac surgery risk scores were measured in all patients. The primary outcome was the STS composite end point of in-hospital postoperative mortality or major morbidity. A total of 152 patients were enrolled, with a mean age of 75.9±4.4 years and 34% women. Depending on the scale used, 20–46% of patients were found to be frail, and 5–76% were found to have at least 1 disability. The most predictive scale in each domain was: 5-meter gait speed ≥6 seconds as a measure of frailty (odds ratio [OR], 2.63; 95% confidence interval [CI], 1.17–5.90), ≥3 impairments in the Nagi scale as a measure of disability (OR, 2.98; 95% CI, 1.35–6.56) and either the Parsonnet score (OR, 1.08; 95% CI, 1.04–1.13) or Society of Thoracic Surgeons Predicted Risk of Mortality or Major Morbidity (STS-PROMM) (OR, 1.05; 95% CI, 1.01–1.09) as a cardiac surgery risk score. Compared with the Parsonnet score or STS-PROMM alone, (area under the curve, 0.68–0.72), addition of frailty and disability provided incremental value and improved model discrimination (area under the curve, 0.73–0.76).

Conclusions—
Clinicians should use an integrative approach combining frailty, disability, and risk scores to better characterize elderly patients referred for cardiac surgery and identify those that are at increased risk.
TMS of the FEF Interferes with Spatial Conflict
Authors: Bardi Lara , Kanai Ryota , Mapelli Daniela , Walsh Vincent 
Published: March 2012

Abstract
In the Simon task, a conflict arises because irrelevant spatial information competes for response selection either facilitating or interfering with performance. Responses are faster when stimulus and response position correspond than when they do not. The FEFs, which have long been characterized for their role in oculomotor control, are also involved in the control of visuospatial attention when eye movements are not required. This study was aimed at investigating whether the FEFs contribute to spatial conflict. Double-pulse TMS was applied to the FEF of either left or right hemisphere during the execution of a Simon task at different time windows after the onset of the visual stimulus. A suppression of the Simon effect was observed after stimulation of the FEF for stimuli appearing in the contralateral hemifield when TMS was applied to the left hemisphere after stimulus onset (0–40 and 40–80 msec). A reduction of the correspondence effect was observed after right FEF TMS for stimuli presented in the left visual hemifield when stimulation was delivered in the 80–120 msec range after stimulus onset. These outcomes indicate that the FEF play a critical role in encoding spatial attribute of a stimulus for response priming, which is the prerequisite for response conflict in the Simon task. Moreover, our finding that the left FEF have a dominant role during spatial conflict extends the idea of the left-hemisphere lateralization of the motor network in action selection by suggesting that the FEF may constitute part of this network.
Human Brain Activity Predicts Individual Differences in Prior Knowledge Use during Decisions
Authors: Hansen Kathleen A. , Hillenbrand Sarah F. , Ungerleider Leslie G. 
Published: March 2012

Abstract
Studies by cognitive psychologists, psychophysicists, neuroscientists, and economists provide ample evidence that humans use prior knowledge to bias decisions adaptively. In this study, we sought to locate and investigate the brain areas mediating this behavior. Participants viewed ambiguous abstract shapes and decided whether a shape was of Category A (smoother) or B (bumpier). The decision was made in the context of one of two prior knowledge cues, 80/20 and 50/50. The 80/20 cue indicated that upcoming shapes had an 80% probability of being of one category, for example, B, and a 20% probability of being of the other. The 50/50 cue indicated that upcoming shapes had an equal probability of being of either category. The shift in bias produced by the 80/20 cue relative to the 50/50 cue was of the predicted sign for every subject but varied in magnitude. We searched for brain regions in which activity changes correlated with the extent of the bias shift; these were dorsolateral pFC (middle frontal gyrus), inferior frontal junction, anterior insula, inferior parietal lobule, intraparietal sulcus, head of the caudate, posterior cingulate cortex, and fusiform gyrus. The findings indicate that an individual's brain activity in these regions reflects the extent to which that individual makes use of prior knowledge to bias decisions. We also created within-ROI tuning curves by binning the shape curvature levels and plotting brain activity levels at each of the nine bins. In the fronto-parietal and anterior insula ROIs, the tuning curves peaked at targets contraindicated by the prior knowledge cue (e.g., Category B targets if the 80/20 cue meant 20% probability B). The increased activity in these regions likely indicates a no-go response when sufficient perceptual evidence favored the alternative contraindicated by the 80/20 cue.
Climate Divisions for Alaska Based on Objective Methods
Authors: Bieniek Peter A. , Bhatt Uma S. , Thoman Richard L. , Angeloff Heather , Partain James , Papineau John , Fritsch Frederick , Holloway Eric , Walsh John E. , Daly Christopher , Shulski Martha , Hufford Gary , Hill David F. , Calos Stavros , Gens Rudiger 
Published: March 2012

AbstractAlaska encompasses several climate types because of its vast size, high-latitude location, proximity to oceans, and complex topography. There is a great need to understand how climate varies regionally for climatic research and forecasting applications. Although climate-type zones have been established for Alaska on the basis of seasonal climatological mean behavior, there has been little attempt to construct climate divisions that identify regions with consistently homogeneous climatic variability. In this study, cluster analysis was applied to monthly-average temperature data from 1977 to 2010 at a robust set of weather stations to develop climate divisions for the state. Mean-adjusted Advanced Very High Resolution Radiometer surface temperature estimates were employed to fill in missing temperature data when possible. Thirteen climate divisions were identified on the basis of the cluster analysis and were subsequently refined using local expert knowledge. Divisional boundary lines were drawn that encompass the grouped stations by following major surrounding topographic boundaries. Correlation analysis between station and gridded downscaled temperature and precipitation data supported the division placement and boundaries. The new divisions north of the Alaska Range were the North Slope, West Coast, Central Interior, Northeast Interior, and Northwest Interior. Divisions south of the Alaska Range were Cook Inlet, Bristol Bay, Aleutians, Northeast Gulf, Northwest Gulf, North Panhandle, Central Panhandle, and South Panhandle. Correlations with various Pacific Ocean and Arctic climatic teleconnection indices showed numerous significant relationships between seasonal division average temperature and the Arctic Oscillation, Pacific–North American pattern, North Pacific index, and Pacific decadal oscillation.