bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of Dutch hospitals in the management of splenectomized patients
Authors: Lammers Jolanda , Veninga Daphne , Speelman Peter , Hoekstra Joost , Lombarts Kiki 
Published: June 2010

AbstractBACKGROUND:After splenectomy, patients are at increased risk of sepsis with considerable mortality. This risk can be reduced by taking preventive measures, such as prescribing immunizations and antibiotic prophylaxis. Studies from various countries show that a substantial percentage of patients are not managed adequately. The aim of the present study was to investigate the quality of care in the prevention of infections after splenectomy in Dutch hospitals. The research questions were two‐fold: (1) Is there an association between hospital teaching status and guideline adherent preventive measures? (2) Which factors contribute to hospital performance?METHODS:A total of 28 Dutch hospitals (30%) participated in the study. A retrospective review of medical records of 536 splenectomy patients was performed. Adherence to prevention guidelines was assessed for all patients, and analyzed according to teaching status and the presence or absence of a post‐splenectomy protocol.RESULTS:(1) University hospitals in the Netherlands offered higher quality of care than other teaching and nonteaching hospitals. There were only small differences between nonuniversity teaching and nonteaching hospitals. (2) The presence of a hospital post‐splenectomy protocol did not improve vaccination rates. Other aspects of practice organization, such as surgical staff size and keeping a complication registry were only weakly related to performance.CONCLUSIONS:In the Netherlands, university hospitals deliver state‐of‐the‐art care in the prevention of infections in asplenic patients more often than nonuniversity teaching and nonteaching hospitals. The availability of a hospital protocol does not seem to contribute to guideline adherence. Journal of Hospital Medicine 2010. © 2010 Society of Hospital Medicine.
Short‐term femoral vein catheterization rarely causes thrombosis or bacteremia
Authors: Casanegra Ana Isabel , Brannan Scott , Dadu Ramona , Ong Philip , Berner Mitchell , Spinning Kristopher , Hughes Terence , Marrinan Greg , Zinn Kenneth , Manthous Constantine 
Published: June 2010

AbstractBACKGROUND:Experts and national regulatory bodies have deemed femoral vein catheterization (FVC) unsafe, and recommend avoiding it whenever possible.OBJECTIVE:To assess rates of catheter‐related bloodstream infections (CRBI) and deep venous thrombosis (DVT) complicating FVC.DESIGN:Prospective observational cohort study.SETTING:Medical intensive care unit (MICU) of a 350‐bed community teaching hospital.PATIENTS:Consecutive admissions to the MICU during 7 months.METHODS:Demographic, laboratory and Doppler ultrasound studies were collected on patients receiving large vein catheters (VC) in our MICU. Ultrasound examinations were systematically performed on the day of and 5 to 7 days after removal of FVC.RESULTS:VC were inserted in 238 (35% of) patients. Of that total, 217 catheters were in large veins (49% FVC, 38% internal jugular and 13% subclavian) for an average of 2.7 days for femoral, 5.7 days for internal jugular and 3.6 days for subclavian vein catheters. During 1200 catheter‐days, no central VC CRBI was identified. Of 107 FVC, initial and follow‐up Doppler studies were performed in 50 patients. A total of 97% of patients received routine thromboprophylaxis and none had a DVT. Of the 57 patients with initial but no Doppler follow‐up at 5 to 7 days following removal, no patient developed clinically detected venous thromboembolism (VTE).CONCLUSION:Short‐term FVC was used safely in our MICU in the setting of thromboprophylaxis. In light of its favorable safety profile for initial resuscitation of critically ill patients, it may be premature to strongly discourage FVC. Journal of Hospital Medicine 2011. © 2010 Society of Hospital Medicine.
Extremely Strong, Uncharged Auxiliary Bases; Monomeric and Polymer‐Supported Polyaminophosphazenes (P2–P5)
Authors: Schwesinger Reinhard , Schlemper Helmut , Hasenfratz Christian , Willaredt Jürgen , Dambacher Tim , Breuer Thomas , Ottaway Carol , Fletschinger Michael , Boele Joachim , Fritz Hans , Putzas Dietmar , Rotter Heinz W. , Bordwell Frederick G. , Satish Amruthur V. , Ji Guo‐Zen , Peters Eva‐Maria , Peters Karl , von Schnering Hans Georg , Walz Leonhard 
Published: June 2010

AbstractThe syntheses and properties of novel, extremely strong uncharged polyaminophosphazene bases up to a high level of steric hindrance are described. Most of the systems were readily prepared in up to molar quantities and conveniently recovered from their salts. They are of appreciable to high chemical and thermal stability. Crystal structures of their salts were determined in order to parametrize a force field, which is utilized in molecular modeling studies. The latter offer a rationalization of the high conformational mobility of these systems. These bases cover a range of ca. 15 pK units in basicity and extend the range of uncharged auxiliary bases by ca. 19 pK units up to DMSOpKBH+ values of 34–35. They are proposed as a novel class of auxiliary bases for deprotonation of very low acidic compounds where chemists have been so far left to classical metalorganic bases. Depending on the basicity range and the degree of steric protection of the basic center, these systems are particularly applicable to E2 elimination or to in situ generation of highly reactive “naked” anions.
Characterization of conjugative plasmids belonging to a new incompatibility group (IncZ)
Authors: Tschäpe H. , Tietze E. 
Published: June 2010

AbstractMore than 30 conjugative R plasmids between 60 and 70 Md in size were identified in wild type strains of Enterobacteriaceae isolated in German Democratic Republic, Bulgaria, Mongolia, Poland, Ethiopia, Iraque, and Soviet Union. They have been characterized by means of several genetic and molecular techniques as members of a new incompatibility group, termed IncZ. The properties of these plasmids including digestion pattern after EcoRI treatment demonstrate a phylogenetic relatedness.
Microbiologically influenced corrosion of archaeological artefacts: characterisation of iron(II) sulfides by Raman spectroscopy
Authors: Rémazeilles Céline , Saheb Mandana , Neff Delphine , Guilminot Elodie , Tran Khoi , Bourdoiseau Jacques‐André , Sabot René , Jeannin Marc , Matthiesen Henning , Dillmann Philippe , Refait Philippe 
Published: June 2010

AbstractArchaeological objects are exposed to the action of micro‐organisms when they lay in a biologically active environment. The presence of iron sulfides in the corrosion system testifies in most cases that the degradation was influenced by sulfate‐reducing bacteria. Iron sulfides and other iron/sulfur‐containing compounds were detected by micro‐Raman spectroscopy in rust layers of archaeological ferrous objects and in wet wooden fragments contaminated by iron, extracted from ancient wrecks. Although mackinawite (FeS) is very reactive towards oxygen, this phase was observed in each sample. Its crystallisation levels and oxidation states could be differentiated. Greigite (Fe3S4) was also identified by means of X‐ray diffraction, used when possible as a complementary analytical tool. Known as the result of the oxidation of mackinawite, greigite was likely to form during the experiments carried out without any protection against air. It was then possible to describe the formation and oxidation processes of iron sulfides in archaeological iron artefacts or in organic materials contaminated by iron. Copyright © 2010 John Wiley & Sons, Ltd.
Raman spectroscopic study on sodium hyaluronate: an effect of proton and γ irradiation
Authors: Synytsya Alla , Synytsya Andriy , Alexa Petr , Wagner Richard , Davídková Marie , Volka Karel 
Published: June 2010

AbstractRaman spectroscopy was applied to the analysis of structural changes in lyophilised sodium hyaluronate after proton and γ irradiation (0.5, 5, 50, 100, 200 and 600 Gy). Characteristic Raman bands of the polysaccharide were sensitive to irradiation. Significant damage was observed at doses of 50 Gy or higher. The spectral changes confirmed radiation‐induced loss of native solution conformation, destruction of primary structure, fragmentation, cross‐linking and elimination of functional groups. Differences in the effects of proton and γ radiation on sodium hyaluronate are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
The transformation of mackinawite into greigite studied by Raman spectroscopy
Authors: Bourdoiseau Jacques‐André , Jeannin Marc , Rémazeilles Céline , Sabot René , Refait Philippe 
Published: June 2010

AbstractIn this study, Raman spectroscopy was used to precisely understand the mechanisms of oxidation of mackinawite (FeS). Two experimental conditions were considered: (1) oxidation in air at room temperature and (2) oxidation in acidic anoxic solutions at 80 °C. In both cases, the oxidation process began by the in situ oxidation of Fe(II) cations inside the crystal structure of mackinawite and led to Fe(III)‐containing mackinawite, FeII1−3xFeIII2xS. The oxidation in air finally led to Fe(III) oxyhydroxides and elemental sulfur α‐S8, but greigite (Fe3S4) was observed as an intermediate compound. In anoxic acidic solutions, the product of the oxidation was proved to depend on the Fe/S concentration ratio. For Fe/S = 3/4, greigite was the only product obtained, and this allowed us to determine unambiguously the Raman spectrum of this compound. Copyright © 2010 John Wiley & Sons, Ltd.
Hepatic artery infusion chemotherapy for colorectal metastases: A personal experience
Authors: Donegan William L. 
Published: June 2010

AbstractA personal experience is reported with hepatic artery infusion (HAI) chemotherapy of 57 patients with metstatic colorectal carcinoma confined to the liver. Fifty‐seven percent of the 54 patients who received more than 2 weeks of infusion had objective regressions documented on hepatic scans. The response rate with fluorouracil and mitomycin C (75%) was higher than for fluorouracil alone (52.5%). The median survival of treated patients was 15 months with the longest survivor living 3 years 8 months, and responders had a median survival 3 months longer than nonresponders. Complications included one case of hemolytic uremic syndrome after HAI with mitomycin C. Survival after HAI was 9 months longer than that of comparable historical controls who received no treatment, but survival after HAI with fluorouracil alone was not superior to that of comparable patients treated with intravenous fluorouracil. HAI produces a high frequency of tumor regression, but superior survival has yet to be demonstrated.
DNA ploidy in gastric cancer with metastasis to the liver
Authors: Kimura Osamu , Kaibara Nobuaki , Makino Masato , Nishidoi Hideaki 
Published: June 2010

AbstractDNA ploidy, assessed microspectrophotometrically in 143 gastric carcinomas, was correlated with the presence or absence of venous invasion and liver metastasis. Patterns of DNA distribution were grouped into cases of low and high ploidy. The incidence of high ploidy was 61.4% in gastric cancers with venous invasion, being statistically different from the incidence of 31.4% in cases without venous invasion (P < 0.05). Furthermore, there was a statistical difference between the incidence of high ploidy in gastric cancers associated with liver metastasis and the incidence of high ploidy in advanced cancers that had been curatively resected and had not recurred for more than 5 years after operation (P < 0.05). These findings indicate a close correlation between DNA ploidy, venous invasion, and liver metastasis, and they suggest the significant clinical value of DNA analysis for the prediction of liver metastasis in patients with gastric carcinoma.
Accuracy and pitfalls of frozen section during thyroid surgery
Authors: Shaha Ashok , Gleich Lyon , Maio Terry Dl , Jaffe Bernard M. 
Published: June 2010

AbstractThe purpose of this study was to assess the accuracy of frozen sections performed during thyroid surgery and to define any pitfalls they may have. The material includes a series of 190 frozen section examinations of thyroid pathology. The overall accuracy of frozen section in this series was 95%. There were no false positives in our series and false negatives related to only follicular adenomas. In two patients, the report was deferred for permanent slide examination. Nine patients had lesions reported as malignant; however, the distinct cell type was not designated on frozen section. Eight specimens initially reported to have follicular adenoma on frozen section turned out to have angioinvasion or capsular invasion indicative of follicular carcinoma. Minor discrepancies between frozen and permanent sections in the types of benign disease were noted occasionally, but were not clinically significant. There was a discrepancy in the diagnosis of Hashimoto's thyroiditis on three occasions. The major discrepancy in patients with malignant pathology was related to the cell type. The diagnosis of anaplastic thyroid cancer, though suspected, was deferred for permanent sections in all cases. The diagnosis of medullary cancer of thyroid was difficult to make on frozen section. The major problem with frozen section was the diagnosis of follicular adenoma versus carcinoma. The benign diagnosis was changed in eight instances (out of 24 frozen sections) from follicular ademona to follicular carcinoma. Because of this experience, we do not provide the frozen section diagnosis to the patient and we wait until the final diagnosis is available.
An alternative approach to nonpalpable breast biopsies
Authors: Reid Stephen E. , Scanlon Edward F. , Bernstein Joel R. , Paige Milton L. , Matsumura Jon , Bailey Lisa 
Published: June 2010

AbstractTraditionally, when a negative specimen radiograph is obtained during biopsy of a nonpalpable breast lesion, immediate re‐excision is performed in an attempt to successfully remove the lesion. Based on a retrospective study of the biopsy results of 792 nonpalpable breast lesions, the authors suggest delaying the re‐excision, despite a negative specimen x‐ray, until postoperative mammography confirms the persistence of the lesion. Utilization of this approach was associated with a comparably low incidence of missed lesions (3%) and had the added advantages of preserving breast tissue and decreasing operative time.
Use of rhodamine 123 in the treatment of the pollard iii rat prostate adenocarcinoma
Authors: Arcadi John A. 
Published: June 2010

AbstractSignificant destruction of the Pollard III rat prostate adenocarcinoma was achieved by treatment with rhodamine 123 at a dosage of 15 mg/kg every other day for 33 to 38 days. Injection of tumor remnants into untreated animals produced no tumor regrowth. Our data have demonstrated rhodamine 123 to be a significant drug for the management of the very aggressive Pollard III tumor.
Combination chemotherapy as induction therapy for advanced resectable head and neck cancer
Authors: Maipang Tanaphon , Maipang Matinee , Geater Alan , Panjapiyakul Chingyiam , Watanaarepornchai Somchai , Punperk Supaporn 
Published: June 2010

AbstractFifty‐four previously untreated patients with locally advanced resectable squamous cell carcinoma of the head and neck (SCCHN) were enrolled into a prospective randomized controlled trial to evaluate whether induction chemotherapy improves the disease‐free survival compared to the standard treatment (surgery + radiation). Thirty patients received chemotherapy, which consisted of cisplatin 20 mg/m2 day 1–5, bleomycin 10 mg/m2, continuous infusion from day 3–7, and methotrexate 40 mg/m2 given on day 15 and day 22. The cycle was repeated on day 29 for two cycles. Twenty patients completed chemotherapy courses. Overall response rate was 77% (23 of 30). No survival improvement was observed. Kaplan‐Meier analysis indicated survival (and 95% confidence interval) at 3 years was 57% (29%‐84%) for the control group and 60% (34%‐87%) for the chemotherapy group, and 57% (29%‐84%) and 45% (12%‐78%) at 4 years (P = 0.736). However, patients who had a complete response were significantly better in terms of long‐term survivors (5 of 7 patients were still alive), in contrast to patients who had partial responses among whom only 4 of 16 were alive. Toxicities of this induction protocol are tolerable; one chemotherapy‐related death occurred from profound thrombocytopenia. If efforts in determining a chemotherapy‐sensitive patient were successfully established, along with a better sequence and the discovery of new and safter drugs, survival of SCCHN should be much improved.
Renal cell carcinoma extending to the renal vein and inferior vena cava: Results of surgical treatment and prognostic factors
Authors: Tongaonkar Hemant B. , Dandekar Niteen P. , Dalal Amish V. , Kulkarni Jagdeesh N. , Kamat Murali R. 
Published: June 2010

AbstractForty‐seven patients with renal cell carcinoma with tumor thrombus extension to the renal vein or inferior vena cava (IVC) were treated surgically over a 10‐year period. There were 41 males and 6 females with a mean age of 45.7 years. Thirty‐three patients had right‐sided and 14 had left‐sided tumors. Patients with renal vein or infrahepatic IVC thrombus were treated with radical nephrectomy with tumor thrombus excision after achieving conventional vascular control over the IVC and the opposite renal vein. Four patients with retrohepatic IVC thrombus were treated with venacavotomy and thrombectomy after achieving vascular control above the thrombus but below the hepatic veins while two other patients with retrohepatic and one with suprahepatic thrombus required a bifemoroatrial partial venous bypass prior to tumor thrombectomy. There was one postoperative death due to pulmonary embolism. The actuarial 5‐year survival for all patients with venous extention was 50% and the median survival was 4.35 years. Perinephric spread and lymph node metastases were significant prognostic factors affecting survival. This suggests that it is the locoregional spread of renal cell carcinoma rather than the level of the thrombus which governs the prognosis of patients with tumor thrombus extension to the renal vein or IVC.
Growth inhibition of intracerebral rat glioma by transfection‐induced human interferon‐β
Authors: Harada Kunyu , Yoshida Jun , Mizuno Masaaki , Kurisu Kaoru , Uozumi Tohru 
Published: June 2010

AbstractIn our previous study on liposome‐mediated transfection of the human interferon‐β (HuIFN‐β) gene into subcutaneously implanted human gliomas in nude mice, we found that HuIFN‐β was produced and secreted by the tumor cells and that the growth of solid tumors was completely inhibited. The present study investigated the growth‐inhibitory effect of liposomes containing the HuIFN‐β gene inserted into a vector (PSV2IFN‐β) on T9 rat glioma implanted into the brains of rats. Tumor cells and liposomes containing pSV2IFN‐β or other additives were simultaneously injected into the brains of rats. HuIFN‐β was detected in solid gliomas growing in the brains of rats injected with liposomes and magnetic resonance imaging (MRI) showed that tumor growth was inhibited. In addition, the latent period until the appearance of neurological symptoms was significantly prologed in rats treated with liposomes containing pSV2IFN‐β. However, the survival time of the treated rats was not significantly increased. © 1995 Wiley‐Liss, Inc.
Chiral separation and quantitation of dorzolamide hydrochloride enantiomers by high‐performance liquid chromatography
Authors: Shamsipur Mojtaba , Heydari Rouhollah , Jamasbi Elahe Sadat , Abdollahpour Assem 
Published: June 2010

AbstractA direct HPLC method for chiral separation of dorzolamide hydrochloride (4S,6S) and its enantiomer (4R,6R) was developed. Dorzolamide (4S,6S) and its antipode were separated on a chiral‐α1‐acid glycoprotein column (150×4.0 mm, 5 μm). The influences of pH, temperature, flow rate, buffer concentration, and organic modifiers of the mobile phase on the retention and enantioselectivity were evaluated. The mobile phase consisted of an ammonium acetate buffer of pH 7.0. The method was validated for linearity, repeatability, accuracy, LOD, and LOQ. Calibration curves were constructed in the range of 0.5–10 μg/mL for dorzolamide (4S,6S) and 0.2–5 μg/mL for its enantiomer (4R,6R). Repeatability (n=6) showed less than 2% RSD. LOD and LOQ of the two enantiomers were found to be 0.2 and 0.5 for dorzolamide (4S,6S), 0.05 and 0.2 for its enantiomer (4R,6R), respectively. The proposed method was applied to the determination of dorzolamide enantiomer (4R,6R) in a raw material and two different eye drop samples.
Preparation and characterization of ceria‐zirconia composite for enrichment and identification of phosphopeptides
Authors: Wu Jian‐Hong , Xiao Kuang , Zhao Yong , Zhang Wei‐Ping , Guo Lin , Feng Yu‐Qi 
Published: June 2010

AbstractCeria‐zirconia composites at different molar ratios were synthesized. Several methods were used to characterize these composites, including X‐ray photoelectron spectroscopy, surface area and surface acid‐base property detection. A one‐step method for isolation and identification of phosphopeptides from peptide mixture was created using these ceria‐zirconia composites. Using tryptic digest of standard phosphorylated protein, we have shown that these enrichment and dephosphorylation activities are effective. The adsorption capacity and catalytic property of ceria‐zirconia composites at different molar ratios and calcinated temperatures were studied. In combination with MALDI‐TOF‐based peptide mass finger printing technique, we have established a method to utilize the enrichment/dephosphorylation dual properties of these ceria‐zirconia composites for the analysis of phosphoprotein in nonfat milk successfully.
Some Limit Theorems for Extremal and Union Shot‐Noise Processes
Authors: Heinrich L. , Molchanov I. S. 
Published: June 2010

AbstractWe study the limiting behaviour of suitably normalized union shot‐noise processesmagnified image, whereFis a set‐valued function on Rd× ℳ︁ is a sequence of i.i.d. random elements on some measurable space [ℳ︁ 𝔐] and Ψ = {xi, i≥ 1} stands for a stationaryd‐dimensional point process whose intensity λ tends to infinity. General results concerning weak convergence of parametrized union shot‐noise processes Ξϵ(t) as ϵ ↓ 0 are obtained (Theorem 5.1 and its corollaries), if the point process λ1dΨ has a weak limit andFsatisfies some technical conditions. An essential tool for proving these results is the notion of regular variation of multivalued functions. Some examples illustrate the applicability of the results.
In situ Localization of Molecules in Crosslinked Particles during Electrohydrodynamic Process: Simple Route to Produce Microcapsules and Fibers with Controlled Release
Authors: Park ChooJin , Hwang Yoon Kyun , Hyun Dong Choon , Jeong Unyong 
Published: June 2010

AbstractThis study reports a spontaneous selective localization of molecules in crosslinked particles during electrospraying and electrospinning polymer solutions containing the particles. It provides a facile way of preparing microcapsules and fibers with controlled release. The dye molecules were phase separated from the crystalline polymer matrix during the electrohydrodynamic process and moved to the solvent‐rich crosslinked particles. The position of the particles in the microcapsules and fibers could be controlled by adjusting compatibility of the particles with the matrix polymer. The microcapsules and fibers did not show the initial burst release of the molecules and gave considerably prolonged release behavior.magnified image