bluuebunny/crossref_metadata_2025_split huggingface dataset:
The heterogeneous impact of China–Europe railway express on the efficiency of logistics industry in node cities
Authors: Niu Yanliang , Liu Jin , Yang Xining , Wang Chuan 
Published: May 2024

PurposeThe spatiotemporal compression effect of China–Europe Railway Express (CR-Express) can reduce the flow costs of resources between China’s node cities. Additionally, it can break through the limitations of low-added-value marine products, significantly impacting the logistics industry efficiency. However, there are few literature verifying and analyzing its heterogeneity. This study explores the impact of CR-Express on the efficiency of logistics industry in node cities and analyzes the heterogeneity.Design/methodology/approachFirst, this study uses panel data to measure the efficiency of node city logistics industry. Secondly, this study discusses the impact of the opening of CR-Express on the efficiency of logistics industry in node cities based on the multi-period differential model. Finally, according to the node city difference, the sample city experimental group is grouped for heterogeneity analysis.FindingsThe results show that CR-Express can promote the urban logistics industry efficiency, with an average effect of 4.55%. According to the urban characteristics classification, the heterogeneity analysis shows that the efficiency improvement effect of logistics industry in inland cities is more obvious. The improvement effect of node cities and central cities in central and western China is stronger, especially in the sample of megacities and type I big cities. Compared with non-value chain industrial products, the CR-Express has significant promotion effects on the logistics efficiency of the cities where main goods are value chain products.Originality/valueUnder the background of double cycle development, this paper can provide a scientific basis for the investment benefit evaluation of CR-Express construction and the follow-up route planning.
Evaluating the mismatch between user requirements and existing situation display tools in administrative crisis management
Authors: Hellmund Tobias , Moßgraber Jürgen 
Published: May 2024

AbstractCrisis management is a challenging and interdisciplinary task in which various information must be acquired and fused. In Germany, Civil Crisis Management is usually organized into two parts: the organizational‐administrative division and the operative‐tactical division, which are subordinate to the authorities (political) leadership. To organize an efficient and interdisciplinary response, crisis staffs can be called up. In these administrative crisis staffs, information sources are bundled, responsible experts collaborate and exchange information. To achieve a common understanding of the crisis, situational displays are created. Situational displays present the extend of the crisis and offer high‐level information required by the staff members. They can show the extent of the crisis area on maps or integrate other, for example numeric, information. This paper presents both state of the art in situational display creation and the most recent requirements in administrative crisis management. Data were collected through structured questionnaires and workshops regarding the tools for the creation of situational displays. For both data gathering methods, we were able to acquire active crisis management experts as participants. To determine the state of the art for situational displays for administrative crisis management staff we utilized structured questionnaires, which were answered by 14 crisis management authorities. Through two expert workshops with each nine participants, the requirements for situational display were collected. This paper compares the two datasets to evaluate the recent state of situational displays for administrative crisis staff in practice. The article summarizes usage of situational displays by practitioners and compiles lessons from the field.
A structured approach to modifying an implementation package while scaling up a complex evidence‐based practice
Authors: Cordasco Kristina M. , Gabrielian Sonya E. , Barnard Jenny , Harris Taylor , Finley Erin P. 
Published: May 2024

AbstractObjectiveTo describe a structured, iterative, data‐driven approach for modifying implementation strategies for a complex evidence‐based practice during a nationwide scale‐up initiative.Data Sources and Study SettingWe scaled‐up implementation of Critical Time Intervention (CTI)—an evidence‐based case management model—across 32 diverse community‐based Veterans Affairs (VA) “Grant and Per Diem” case management (GPD‐CM) agencies that serve homeless‐experienced Veterans transitioning to independent living. Primary data were collected using qualitative methods.Study DesignWe embarked on a scale‐up initiative while conducting a pragmatic randomized evaluation using a roll‐out design, comparing two versions of a CTI implementation package tailored to VA's GPD‐CM program. We iteratively assessed contextual factors and implementation outcomes (e.g., acceptability); findings informed package modifications that were characterized using the Framework for Reporting Adaptations and Modifications to Evidence‐based Implementation Strategies.Data Collection MethodsWe conducted semi‐structured interviews with Veterans, GPD‐CM staff, and liaising VA clinicians; periodic reflections with liaising VA clinicians and implementation team members; and drew upon detailed meeting notes. We used rapid qualitative methods and content analysis to integrate data and characterize modifications.Principal FindingsAfter each scale‐up wave—in response to variations in agency‐level characteristics— we made iterative modifications to the implementation package to increase CTI adoption and fidelity across the diverse contexts of our scale‐up sites. Modifications included adding, deleting, integrating, and altering the package; core package components were preserved.ConclusionsImplementation packages for complex evidence‐based practices undergoing scale‐up in diverse contexts may benefit from iterative modifications to optimize practice adoption with fidelity. We offer a structured, pragmatic approach for iteratively identifying data‐driven, midstream implementation package adjustments, for use in both VA and non‐VA scale‐up initiatives. Our project demonstrates the importance of assessing for and making modifications in a scale‐up initiative, as well as the trade‐offs of projects having simultaneous formative and summative evaluation aims.
Gestational exposure to benzodiazepines or z‐hypnotics and neurodevelopmental disorders in offspring: Systematic review and meta‐analysis
Authors: Andrade Chittaranjan , Varadharajan Natarajan , Bascarane Sharmi , Menon Vikas 
Published: May 2024

AbstractIntroductionBenzodiazepine (BDZP) and/or z‐hypnotic dispensing during pregnancy has increased globally, as have rates of autism spectrum disorder (ASD) and attention‐deficit hyperactivity disorder (ADHD). This systematic review and meta‐analysis aimed to estimate the association between gestational exposure to BDZP and/or z‐hypnotics and diagnosis of ASD or ADHD in offspring.MethodsWe searched MEDLINE, EMBASE, and SCOPUS from inception till December 2023 for relevant English‐language articles. Outcomes of interest were risk of ASD and ADHD, two independent primary outcomes, in children exposed anytime during pregnancy to BDZP and/or z‐hypnotics versus those unexposed. Secondary outcomes were trimester‐wise analyses. Using a random effects model, we pooled the overall and trimester‐wise hazard ratios (HRs), with 95% confidence intervals (CIs), separately for risk of ASD and ADHD.ResultsWe found six eligible retrospective cohort studies and no case–control studies. There was no increased risk of ASD associated with anytime gestational BDZP and/or z‐hypnotic exposure (primary outcome, HR, 1.10; 95% CI, 0.81–1.50; 4 studies; n = 3,783,417; 80,270 exposed, 3,703,147 unexposed) nor after first trimester exposure (HR, 1.15; 95% CI, 0.83–1.58; 3 studies; n = 1,539,335; 70,737 exposed, 1,468,598 unexposed) or later trimester exposures. A very small but significantly increased risk of ADHD was noted with anytime gestational exposure to these drugs (primary outcome, HR, 1.07; 95% CI, 1.03–1.12; 4 studies; n = 2,000,777; 78,912 exposed, 1,921,865 unexposed) and also with (only) second trimester exposure (HR, 1.07; 95% CI, 1.03–1.12; 3 studies; n = 1,539,281; 33,355 exposed, 1,505,926 unexposed). Findings were consistent in sensitivity analyses.ConclusionGestational exposure to benzodiazepines or z‐hypnotics was not associated with an increased risk of ASD and with only a marginally increased risk of ADHD in offspring. Given the likelihood of confounding by indication and by unmeasured variables in the original studies, our findings should reassure women who need these medications for severe anxiety or insomnia during pregnancy.
The “most bothersome symptom” construct: A qualitative study of Australians living with endometriosis
Authors: Mitchell Alice M. , Rajapakse Danushi , Peate Michelle , Chalmers K. Jane , Kamper Steven J. , Frawley Helena , Cheng Claudia , Healey Martin , Lensen Sarah 
Published: May 2024

AbstractIntroduction“Improvement in the most bothersome symptom” was recently selected as a core outcome for endometriosis intervention trials. This study aimed to explore the applicability of the construct of “symptom bother” in representing the lived experiences of people with endometriosis.Material and MethodsSemi‐structured interviews were conducted to understand the meaning of “symptom bother” and related constructs. Eighteen interviews were conducted: 14 among people with a surgical diagnosis of endometriosis who were recruited from the community, and four with people who were recruited from a private gynecology clinic who had either a confirmed diagnosis or a high suspicion of the disease. All interviews were audio recorded, transcribed verbatim, and analyzed thematically.ResultsThree primary themes were identified: (1) endometriosis symptoms and priorities vary with time and context, (2) endometriosis symptoms impair normal daily functioning, (3) endometriosis symptoms are more than just a “bother.” The concept of “bother” to describe endometriosis symptoms did not resonate with most participants. Whilst “bother” was familiar language, it did not encompass the broader implications of living with endometriosis. Participants felt “bother” implied emotional distress, lacking a full understanding of the consequences of the disease. Instead, “symptom impact” was endorsed, allowing participants to quantify and objectively assess their symptoms, free from negative connotations.ConclusionsThis was the first qualitative study to explore “symptom bother” among people living with endometriosis. Instead of “bother,” “impact” was widely endorsed as a suitable construct. This term more appropriately captured the broad ways in which endometriosis symptoms impair daily functioning.
Taking shape: A new geometric morphometric approach to quantifying dental fluctuating asymmetry and its application to the evaluation of developmental stress
Authors: Wigley Ben , Stillman Eleanor , Craig‐Atkins Elizabeth 
Published: May 2024

AbstractAlthough evaluating developmental stress is challenging, it is critical to understanding phenotypic adaptation and differentials in morbidity and mortality related to spatiotemporal variation in environmental and cultural factors. This paper presents a new, reproducible, and reliable geometric morphometric (GM) protocol through which stress‐induced deviations to symmetry, known as fluctuating asymmetry (FA), can be robustly quantified. A case study, in which maternally mediated early‐life stress in human skeletal remains is explored through first permanent molar (M1) FA, illustrates the method's effectiveness and wide‐ranging potential to revolutionise the investigation of themes such as stress intensity, developmental processes, and buffering mechanisms in past populations.
Corruption spills over on citizens: The case of self‐reported motivation to cheat on tax
Authors: Siddique Abu Bakkar 
Published: May 2024

AbstractCorruption poses a significant threat to societies’ social and economic fabric, eroding trust and contractual relationships between governments and citizens. This study investigates the repercussions of corruption spillover on individuals and explores how they adjust their motivation to engage in tax cheating by exploiting two distinct types of corruption heterogeneities at both individual and national levels. Leveraging newly collected individual corruption experiences locally from the World Value Survey alongside national‐level corruption data from Transparency International, we employ multilevel hierarchical modeling to estimate the effects of corruption on individual tax behavior. Our findings reveal that corruption negatively impacts people's willingness to comply with tax laws, with individuals who have personally experienced corruption exhibiting a more pronounced erosion of tax morale compared to those who have not. By shedding light on the intricate dynamics of corruption's influence on tax compliance, this paper contributes to our understanding of the broader implications of corruption for people and society. This paper can also inform policymakers and stakeholders in designing targeted interventions to mitigate the adverse consequences of corruption and restore citizens’ trust in their government.
Pituitary‐related immune adverse events induced by programmed death Protein‐1 inhibitors differ clinically from hypophysitis
Authors: Yang Lijuan , Zhang Yao , Chen Xiaoyu , Liu Kuanzhi , Zhou Yaru , Wang Shuchang 
Published: May 2024

AbstractObjectiveWe aimed to elucidate the clinical features of pituitary immune‐related adverse events (irAEs) induced by PD‐1 inhibitors in a Chinese cohort and the previous literatures.Patients and Design and MeasurementsWe retrospectively analysed the clinical manifestations, laboratory examination findings, imaging features and treatments of 14 patients with pituitary irAEs caused by PD‐1 inhibitors in our cohort. In addition, we searched PubMed for all English articles on pituitary irAEs induced by PD‐1 inhibitors published from 1950 to 2023. A total of 47 articles were included, and the clinical characteristics of 94 patients with pituitary irAEs induced by PD‐1 inhibitors in these literatures were compared to the characteristics of our cohort.ResultsAmong the 14 patients in our cohort with pituitary irAEs induced by PD‐1 inhibitors, 12 patients (85.71%, 12/14) exhibited isolated ACTH deficiency (IAD), 100.0% (14/14) of the central adrenocortical insufficiency, and 2 patients showed more than one hypothalamic‐pituitary axis injury (14.29%, 2/14). Pituitary magnetic resonance imaging in all the 14 patients showed no pituitary enlargement. In previous studies we reviewed, 82.98% of the total (78/94) presented with pituitary irAEs as IAD, 100.0% (94/94) of the central adrenocortical insufficiency, and 78.33% of the patients showed no abnormality of the pituitary gland (47/60). The pituitary irAEs caused by PD‐1 inhibitors did not involve typical manifestations of hypophysitis, such as pituitary enlargement, headache, visual field defects, and multiple pituitary function impairments in our cohort and the previous literatures.ConclusionIn our study, pituitary immune‐related adverse reactions induced by PD‐1 inhibitors mainly manifested isolated ACTH deficiency rather than hypophysitis.
The Impact of Mandatory Operating Information Disclosure on Related‐Party Transactions: Evidence From China
Authors: He Yan , Wang Jing , Meng Qingxi 
Published: May 2024

ABSTRACTResearch Question/IssueWe investigate the impact of mandatory operating information disclosure rules on related‐party transactions (RPTs) in Chinese‐listed firms. To achieve this, we use the staggered implementation of China's Industry Disclosure Guidelines (CIDG) as an exogenous shock to firms' operating information. We then examine how this regulatory change influences controlling shareholders' expropriation behavior through RPTs.Research Findings/InsightsThe implementation of CIDG results in a reduction in suspicious RPTs, indicating that the mandatory disclosure of operating information effectively mitigates expropriation behavior by controlling shareholders. Additionally, we observe improvements in both the quantity and quality of disclosures after the CIDG, which enhances corporate governance by increasing investor attention and improving the efficiency of regulatory inquiries into RPTs. In our cross‐sectional analysis, the impact of the CIDG is more pronounced for firms with weaker internal controls, lower institutional holdings, and a weaker institutional environment as compared to their counterparts, suggesting a “substitution effect” between the CIDG and firms' internal and external governance mechanisms.Theoretical/Academic ImplicationsThis study contributes to addressing the challenge of curbing opportunistic RPTs in emerging markets. Our study contributes to previous research by emphasizing the crucial role of operating information. This information enhances outsiders' ability to comprehensively understand and utilize disclosed numbers, thereby compensating for a firm's weak corporate governance and restraining expropriation by controlling shareholders. We also provide evidence that corporate governance can be strengthened by improving operational transparency. Our study also contributes to the literature on the actual effect of information on managerial behavior.Practitioner/Policy ImplicationsThis study has several important policy implications. Providing sufficient operating information to minority shareholders and other monitors can empower them to oversee controlling shareholders' behavior effectively. Policymakers can enhance market discipline by reforming information disclosure rules and promoting industry‐level transparency, particularly in emerging markets that have insufficient investor protection against tunneling.
Brief apnea with hypoventilation reduces seizure duration and shifts seizure location for several hours in a model of severe traumatic brain injury
Authors: Rodriguez Lara Frances , Sunkavalli Praneel , Mikaelian Michael , Golemb Bryan , Chung David Y. , Duhaime Ann‐Christine , Staley Kevin , Costine‐Bartell Beth 
Published: May 2024

AbstractObjectiveSeizures can be difficult to control in infants and toddlers. Seizures with periods of apnea and hypoventilation are common following severe traumatic brain injury (TBI). We previously observed that brief apnea with hypoventilation (A&H) in our severe TBI model acutely interrupted seizures. The current study is designed to determine the effect of A&H on subsequent seizures and whether A&H has potential therapeutic implications.MethodsPiglets (1 week or 1 month old) received multifactorial injuries: cortical impact, mass effect, subdural hematoma, subarachnoid hemorrhage, and seizures induced with kainic acid. A&H (1 min apnea, 10 min hypoventilation) was induced either before or after seizure induction, or control piglets received subdural/subarachnoid hematoma and seizure without A&H. In an intensive care unit, piglets were sedated, intubated, and mechanically ventilated, and epidural electroencephalogram was recorded for an average of 18 h after seizure induction.ResultsIn our severe TBI model, A&H after seizure reduced ipsilateral seizure burden by 80% compared to the same injuries without A&H. In the A&H before seizure induction group, more piglets had exclusively contralateral seizures, although most piglets in all groups had seizures that shifted location throughout the several hours of seizure. After 8–10 h, seizures transitioned to interictal epileptiform discharges regardless of A&H or timing of A&H.SignificanceEven brief A&H may alter traumatic seizures. In our preclinical model, we will address the possibility of hypercapnia with normoxia, with controlled intracranial pressure, as a therapeutic option for children with status epilepticus after hemorrhagic TBI.
Hydrothermal carbonization: Sustainable pathways for waste‐to‐energy conversion and biocoal production
Authors: Singh Ajit , Bin Abu Sofian Abu Danish Aiman , Chan Yi Jing , Chakrabarty Anita , Selvarajoo Anurita , Abakr Yousif Abdalla , Show Pau Loke 
Published: May 2024

AbstractHydrothermal carbonization (HTC) technology emerges as a sustainable method to convert wet biomass, including food waste and municipal solid waste into high‐energy dense biocoal. This process, conducted at temperatures ranging from 180 to 260°C and pressures of 10–50 bar, effectively transforms the organic material in wet biomass into solid, liquid, and gaseous outputs. The solid product, biocoal, possesses a high carbon concentration and heating values on par with lignite coal, presenting a cleaner alternative to traditional fossil fuels. Despite operational commercial‐scale HTC facilities globally, further adoption across various feedstocks can improve waste management and energy production. The process can achieve energy yields up to 80%, particularly at temperatures favoring the generation of secondary char with higher heating values. HTC not only aids in reducing greenhouse gas emissions through carbon sequestration in solid waste but also promotes environmental sustainability by yielding nutrient‐rich by‐products for agriculture. As a versatile and energy‐efficient solution, HTC technology is a pivotal innovation in waste‐to‐energy conversion, addressing the imperative for sustainable waste management. Other supplementary benefits are presented; they include higher employability, reduction of a nation's reliance on imported energy, and better waste control, therefore considering all pillars of sustainability. Future research should focus on optimizing process efficiency and exploring the broader applicability of HTC to various biomass feedstocks, enhancing its role in the global pursuit of sustainable energy solutions.
Can fecal microbiota transplantations modulate autoimmune responses in type 1 diabetes?
Authors: Fuhri Snethlage Coco M. , de Wit Douwe , Wortelboer Koen , Rampanelli Elena , Hanssen Nordin M. J. , Nieuwdorp Max 
Published: May 2024

SummaryType 1 diabetes (T1D) is a chronic autoimmune disease targeting insulin‐producing pancreatic beta cells. T1D is a multifactorial disease incorporating genetic and environmental factors. In recent years, the advances in high‐throughput sequencing have allowed researchers to elucidate the changes in the gut microbiota taxonomy and functional capacity that accompany T1D development. An increasing number of studies have shown a role of the gut microbiota in mediating immune responses in health and disease, including autoimmunity. Fecal microbiota transplantations (FMT) have been largely used in murine models to prove a causal role of the gut microbiome in disease progression and have been shown to be a safe and effective treatment in inflammatory human diseases. In this review, we summarize and discuss recent research regarding the gut microbiota–host interactions in T1D, the current advancement in therapies for T1D, and the usefulness of FMT studies to explore microbiota–host immunity encounters in murine models and to shape the course of human type 1 diabetes.