bluuebunny/crossref_metadata_2025_split huggingface dataset:
DAYS OF RUSSIAN CULTURE IN NOVI SAD, ROUND TABLE «PUSHKIN IN SERBIA»
Authors: Младенович Марианна , Пашков А.В. 
Published: June 2024

Статья посвящена Дням русского языка в Нови-Саде и состоявшемуся в их рамках круглому столу «Пушкин в Сербии».
The article is devoted to the Russian Language Days in Novi-Sad and the round table «Pushkin in Serbia» held within their framework.
On the Origin of the Variety of Velocity Dispersion Profiles of Galaxies
Authors: Han San , Yi Sukyoung K. , Oh Sree , Pak Mina , Croom Scott , Devriendt Julien , Dubois Yohan , Kimm Taysun , Kraljic Katarina , Pichon Christophe , Volonteri Marta 
Published: June 2024

Abstract
Observed and simulated galaxies exhibit a significant variation in their velocity dispersion profiles. We examine the inner and outer slopes of stellar velocity dispersion profiles using integral field spectroscopy data from two surveys, SAMI (for z < 0.115) and CALIFA (for z < 0.03), comparing them with results from two cosmological hydrodynamic simulations: Horizon-AGN (for z = 0.017) and NewHorizon (for z ≲ 1). The simulated galaxies closely reproduce the variety of velocity dispersion slopes and stellar mass dependence of both inner and outer radii (0.5 r
50 and 3 r
50) as observed, where r
50 stands for half-light radius. The inner slopes are mainly influenced by the relative radial distribution of the young and old stars formed in situ: a younger center shows a flatter inner profile. The presence of accreted (ex situ) stars has two effects on the velocity dispersion profiles. First, because they are more dispersed in spatial and velocity distributions compared to in situ formed stars, it increases the outer slope of the velocity dispersion profile. It also causes the velocity anisotropy to be more radial. More massive galaxies have a higher fraction of stars formed ex situ and hence show a higher slope in outer velocity dispersion profile and a higher degree of radial anisotropy. The diversity in the outer velocity dispersion profiles reflects the diverse assembly histories among galaxies.
Effects of Alpha Particle Fraction on Kinetic Plasma Turbulence
Authors: Xiong Q. Y. , Parashar Tulasi N. , Huang S. Y. , Yang Y. , Yuan Z. G. , Zhang J. , Jiang K. , Yu L. 
Published: June 2024

Abstract
Solar activities have an extraordinary impact on interplanetary space, enriching the plasma dynamics including turbulent heating of various species. The small fraction of alpha particles is believed to play a significant role in the turbulent dynamics of the solar wind. Here we present fully kinetic particle-in-cell simulations to reveal the influences of the alpha particles in decaying plasma turbulence. Multiple run cases with different controlled variations of proton and alpha density are performed to compare and evaluate the energy conversion processes. It is found that the alpha particles can suppress the energy conversion rate with increasing density. Besides, the alpha particles show more heating intermittency than the proton species. Interestingly, on the other hand, the electrons do not show any change in their dynamics, including overall heating. These two positive charge species have more correlation in temperature anisotropy as their densities are comparable. Our results provide valuable insights on the turbulence with different species compositions to a certain extent, especially with abundant heavy particles.
The Effect of a Dark Matter Core on the Structure of a Rotating Neutron Star
Authors: Konstantinou Andreas 
Published: June 2024

Abstract
Neutron stars represent unique laboratories, offering insights into the physics of supranuclear-density matter and serving as potential hosts for dark matter. This study explores the impact of dark matter cores on rapidly rotating neutron stars through the two-fluid approximation, assuming minimal interaction between baryonic matter and dark matter. The investigation employs phenomenological models for fermionic and bosonic dark matter, revealing that universal relations governing mass and radius changes due to rotation remain largely unaffected in the presence of a dark matter core. Specifically, for a 5% dark matter mass fraction, the percent deviations in total mass (M
tot), the baryonic equatorial radius (R
Be), and polar-to-equatorial baryonic radius ratio (R
ratioB) are within 3.9%, 1.8%, and 1.4%, respectively. These findings suggest that the universal relations governing neutron star shape can be utilized to infer constraints on the properties of dark matter cores even in cases where the dark matter significantly softens the neutron star’s equation of state.
Soft No More: Gas Shielding Protects Soft Binaries from Disruption in Gas-rich Environments
Authors: Rozner Mor , Perets Hagai B. 
Published: June 2024

Abstract
Binaries in dense environments are traditionally classified as soft or hard based on their binding energy relative to the kinetic energy of surrounding stars. Heggie’s law suggests that stellar encounters tend to soften soft binaries and harden hard binaries, altering their separations. However, interactions with gas in such environments can significantly modify this behavior. This study investigates the impact of gas on binary softening and its consequences. We find that gas interactions can actually harden binaries, extending the soft–hard boundary to larger separations. This introduces a “shielding radius” within which binaries are likely to harden due to gas interactions, surpassing the traditional soft–hard limit. Consequently, a notable portion of binaries initially classified as “soft” may become “hard” when both gas and stars are considered. We propose a two-stage formation process for hard binaries: initial soft binary formation, either dynamically or through gas-assisted capture, followed by gas-induced hardening before eventual disruption. In environments with low gas density but high gas content, the shielding radius could exceed the typical hard–soft limit by 1 order of magnitude, leading to a significant fraction of originally soft binaries effectively becoming hard. Conversely, in high-gas-density environments, gas-induced hardening may dominate, potentially rendering the entire binary population hard. Gas hardening emerges as a crucial factor in shaping binary populations in gas-rich settings, such as clusters, star-forming regions, and possibly active galactic nucleus disks. This highlights the complex interplay between gas dynamics and stellar interactions in binary evolution within dense environments.
New Galaxy UV Luminosity Constraints on Warm Dark Matter from JWST
Authors: Liu Bin , Shan Huanyuan , Zhang Jiajun 
Published: June 2024

Abstract
We exploit the recent James Webb Space Telescope (JWST) determination of galaxy UV luminosity functions over the redshift range z = 9–14.5 to derive constraints on warm dark matter (WDM) models. The delayed structure formations in WDM universes make high-redshift observations a powerful probe to set limits on the particle mass m
x of WDM candidates. By integrating these observations with blank-field surveys conducted by the Hubble Space Telescope (HST) at redshifts z = 4–8, we impose constraints on both astrophysical parameters (β, γ, ϵ
N, and M

c
for a double-power-law star formation efficiency, and

σ

M

UV

for a Gaussian magnitude–halo mass relation) and the WDM parameter (dark matter particle mass m
x) simultaneously. We find a new limit of m
x ≥ 3.2 keV for the mass of thermal relic WDM particles at a 95% confidence level. This bound is tighter than the most stringent result derived using HST data before. Future JWST observations could further reduce the observation uncertainties and improve this constraint.
Analysis of metabolic characteristics of metabolic syndrome in elderly patients with gastric cancer by non-targeted metabolomics
Authors: Zhang Huan , Shen Wen-Bing , Chen Lin 
Published: June 2024

BACKGROUND
The relationship between metabolic syndrome (MetS) and gastric cancer (GC), which is a common metabolic disease, has attracted much attention. However, the specific metabolic characteristics of MetS in elderly patients with GC remain unclear.
AIM
To investigate the differentially abundant metabolites and metabolic pathways between preoperative frailty and MetS in elderly patients with GC based on nontargeted metabolomics techniques.
METHODS
In this study, 125 patients with nonfrail nonmeal GC were selected as the control group, and 50 patients with GC in the frail group were selected as the frail group. Sixty-five patients with GC combined with MetS alone were included in the MetS group, and 50 patients with GC combined with MetS were included in the MetS group. Nontargeted metabolomics techniques were used to measure plasma metabolite levels by ultrahigh-performance liquid chromatography-mass spectrometry. Multivariate statistical analysis was performed by principal component analysis, orthogonal partial least squares, pattern recognition analysis, cluster analysis, and metabolic pathway annotation.
RESULTS
A total of 125 different metabolites, including amino acids, glycerophospholipids, sphingolipids, fatty acids, sugars, nucleosides and nucleotides, and acidic compounds, were identified via nontargeted metabolomics techniques. Compared with those in the control group, there were 41, 32, and 52 different metabolites in the MetS group, the debilitated group, and the combined group, respectively. Lipid metabolites were significantly increased in the MetS group. In the weak group, amino acids and most glycerol phospholipid metabolites decreased significantly, and fatty acids and sphingosine increased significantly. The combined group was characterized by significantly increased levels of nucleotide metabolites and acidic compounds. The alanine, aspartic acid, and glutamate metabolic pathways were obviously enriched in the asthenic group, and the glycerol and phospholipid metabolic pathways were obviously enriched in the combined group.
CONCLUSION
Elderly GC patients with simple frailty, simple combined MetS, and frailty combined with MetS have different metabolic characteristics, among which amino acid and glycerophospholipid metabolite levels are significantly lower in frail elderly GC patients, and comprehensive supplementation of fat and protein should be considered. Many kinds of metabolites, such as amino acids, lipids, nucleotides, and acidic compounds, are abnormally abundant in patients with MetS combined with fthenia, which may be related to tumor-related metabolic disorders.
Predictive value of preoperative routine examination for the prognosis of patients with pT2N0M0 or pT3N0M0 colorectal cancer
Authors: Jing Peng-Fei , Chen Jin , Yu En-Da , Miao Chao-Yu 
Published: June 2024

BACKGROUND
In recent years, the incidence of colorectal cancer (CRC) has been increasing. With the popularization of endoscopic technology, a number of early CRC has been diagnosed. However, despite current treatment methods, some patients with early CRC still experience postoperative recurrence and metastasis.
AIM
To search for indicators associated with early CRC recurrence and metastasis to identify high-risk populations.
METHODS
A total of 513 patients with pT2N0M0 or pT3N0M0 CRC were retrospectively enrolled in this study. Results of blood routine test, liver and kidney function tests and tumor markers were collected before surgery. Patients were followed up through disease-specific database and telephone interviews. Tumor recurrence, metastasis or death were used as the end point of study to find the risk factors and predictive value related to early CRC recurrence and metastasis.
RESULTS
We comprehensively compared the predictive value of preoperative blood routine, blood biochemistry and tumor markers for disease-free survival (DFS) and overall survival (OS) of CRC. Cox multivariate analysis demonstrated that low platelet count was significantly associated with poor DFS [hazard ratio (HR) = 0.995, 95% confidence interval (CI): 0.991-0.999, P = 0.015], while serum carcinoembryonic antigen (CEA) level (HR = 1.008, 95%CI: 1.001-1.016, P = 0.027) and serum total cholesterol level (HR = 1.538, 95%CI: 1.026-2.305, P = 0.037) were independent risk factors for OS. The cutoff value of serum CEA level for predicting OS was 2.74 ng/mL. Although the OS of CRC patients with serum CEA higher than the cutoff value was worse than those with lower CEA level, the difference between the two groups was not statistically significant (P = 0.075).
CONCLUSION
For patients with T2N0M0 or T3N0M0 CRC, preoperative platelet count was a protective factor for DFS, while serum CEA level was an independent risk factor for OS. Given that these measures are easier to detect and more acceptable to patients, they may have broader applications.
Association between Helicobacter pylori infection, mismatch repair, HER2 and tumor-infiltrating lymphocytes in gastric cancer
Authors: Castaneda Carlos A , Castillo Miluska , Bernabe Luis A , Sanchez Joselyn , Fassan Matteo , Tello Katherine , Wistuba Ignacio Ivan , Chavez Passiuri Ivan , Ruiz Eloy , Sanchez Juvenal , Barreda Fernando , Valdivia Daniel , Bazan Yaqueline , Abad-Licham Milagros , Mengoa Claudio , Fuentes Hugo , Montenegro Paola , Poquioma Ebert , Alatrista Raul , Flores Claudio J , Taxa Luis 
Published: June 2024

BACKGROUND
The influence of Helicobacter-pylori (H. pylori ) infection and the characteristics of gastric cancer (GC) on tumor-infiltrating lymphocyte (TIL) levels has not been extensively studied. Analysis of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive information.
AIM
To determine the rates of deficient mismatch-repair (dMMR), HER2-status and H. pylori infection and their association with TIL levels in GC.
METHODS
Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral (IT), stromal (ST) and invasive-border (IB) compartments. The density of CD3, CD8 and CD163 immune cells, and dMMR and HER2-status were determined by immunohistochemistry (IHC). H. pylori infection was evaluated by routine histology and quantitative PCR (qPCR) in a subset of samples.
RESULTS
dMMR was found in 34.4%, HER2+ in 5% and H. pylori -positive in 55.7% of samples. High IT-TIL was associated with grade-3 (P = 0.038), while ST-TIL with grade-1 (P < 0.001), intestinal-histology (P < 0.001) and no-recurrence (P = 0.003). dMMR was associated with high TIL levels in the ST (P = 0.019) and IB (P = 0.01) compartments, and ST-CD3 (P = 0.049) and ST-CD8 (P = 0.05) densities. HER2- was associated with high IT-CD8 (P = 0.009). H. pylori -negative was associated with high IT-TIL levels (P = 0.009) when assessed by routine-histology, and with high TIL levels in the 3 compartments (P = 0.002-0.047) and CD8 density in the IT and ST compartments (P = 0.001) when assessed by qPCR. A longer overall survival was associated with low IT-CD163 (P = 0.003) and CD8/CD3 (P = 0.001 in IT and P = 0.002 in ST) and high IT-CD3 (P = 0.021), ST-CD3 (P = 0.003) and CD3/CD163 (P = 0.002).
CONCLUSION
TIL levels were related to dMMR and H. pylori -negativity. Low CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.
Extrahepatic cholestasis associated with paracoccidioidomycosis: Challenges in the differential diagnosis of biliopancreatic neoplasia
Authors: dos Santos José Sebastião , de Moura Arrais Vitor , Rosseto Ferreira William José , Ribeiro Correa Filho Ricardo , Brunaldi Mariângela Ottoboni , Kemp Rafael , Sankanrakutty Ajith Kumar , Elias Junior Jorge , Bellissimo-Rodrigues Fernando , Martinez Roberto , Zangiacomi Martinez Edson , Ardengh José Celso 
Published: June 2024

BACKGROUND
Paracoccidioidomycosis (PCM) may involve the hepatic pedicle and peripancreatic lymph nodes, cause damage to the bile duct and manifest, exceptionally, in combination with extrahepatic cholestasis (EHC), making investigation and treatment challenging.
AIM
To investigate the management of patients with visceral PCM admitted with EHC.
METHODS
All patients diagnosed with PCM treated in a public, tertiary teaching hospital between 1982 and 2020 were retrospectively evaluated. Those also identified with EHC were allocated to two groups according to the treatment approach for the purpose of comparing clinical, laboratory, and imaging findings, resources used for etiological diagnosis, treatment results, and prognosis. Statistical analyses were performed using the linear mixed-effects model (random and fixed effects), which was adjusted using the PROC MIXED procedure of the SAS® 9.0 software, and Fisher’s exact test.
RESULTS
Of 1645 patients diagnosed with PCM, 40 (2.4%) had EHC. Of these, 20 (50.0%) lived in the rural area and 29 (72.5%) were men, with a mean age of 27.1 years (3-65 years). Jaundice as first symptom and weight loss of at least 10 kg were observed in 16 patients (40.0%), and a mass in the head of the pancreas was observed in 8 (20.0%). The etiological diagnosis was made by tissue collection during surgery in 4 cases (10.0%) and by endoscopic methods in 3 cases (7.5%). Twenty-seven patients (67.5%) received drug treatment alone (Group 1), whereas 13 (32.5%) underwent endoscopic and/or surgical procedures in combination with drug treatment (Group 2). EHC was significantly reduced in both groups (40.7% in Group 1, with a mean time of 3 months; and 38.4% in Group 2, with a mean time of 7.5 months), with no statistically significant difference between them. EHC recurrence rates, associated mainly with treatment nonadherence, were similar in both groups: 37% in Group 1 and 15.4% in Group 2. The mortality rate was 18.5% in Group 1 and 23% in Group 2, with survival estimates of 71.3% and 72.5%, respectively, with no statistically significant difference.
CONCLUSION
Although PCM-related EHC is rare, it needs to be included in the differential diagnosis of malignancies, as timely treatment can prevent hepatic and extrahepatic sequelae.
Development of a novel staging classification for Siewert II adenocarcinoma of the esophagogastric junction after neoadjuvant chemotherapy
Authors: Zhang Jian , Liu Hao , Yu Hang , Xu Wei-Xiang 
Published: June 2024

BACKGROUND
Stage classification for Siewert II adenocarcinoma of the esophagogastric junction (AEG) treated with neoadjuvant chemotherapy (NAC) has not been established.
AIM
To investigate the optimal stage classification for Siewert II AEG with NAC.
METHODS
A nomogram was established based on Cox regression model that analyzed variables associated with overall survival (OS) and disease-specific survival (DSS). The nomogram performance in terms of discrimination and calibration ability was evaluated using the likelihood-ratio test, Akaike information criterion, Harrell concordance index, time-receiver operating characteristic curve, and decision curve analysis.
RESULTS
Data from 725 patients with Siewert type II AEG who underwent neoadjuvant therapy and gastrectomy were obtained from the Surveillance, Epidemiology, and End Results database. Univariate and multivariate analyses revealed that sex, marital status, race, ypT stage, and ypN stage were independent prognostic factors of OS, whereas sex, race, ypT stage, and ypN stage were independent prognostic factors for DSS. These factors were incorporated into the OS and DSS nomograms. Our novel nomogram model performed better in terms of OS and DSS prediction compared to the 8th American Joint Committee of Cancer pathological staging system for esophageal and gastric cancer. Finally, a user-friendly web application was developed for clinical use.
CONCLUSION
The nomogram established specifically for patients with Siewert type II AEG receiving NAC demonstrated good prognostic performance. Validation using external data is warranted before its widespread clinical application.
Comprehensive analysis of clinical and biological value of ING family genes in liver cancer
Authors: Liu Shi-Cai 
Published: June 2024

BACKGROUND
Liver cancer (LIHC) is a malignant tumor that occurs in the liver and has a high mortality in cancer. The ING family genes were identified as tumor suppressor genes. Dysregulated expression of these genes can lead to cell cycle arrest, senescence and/or apoptosis. ING family genes are promising targets for anticancer therapy. However, their role in LIHC is still not well understood.
AIM
To have a better understanding of the important roles of ING family members in LIHC.
METHODS
A series of bioinformatics approaches (including gene expression analysis, genetic alteration analysis, survival analysis, immune infiltration analysis, prediction of upstream microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) of ING1 , and ING1 -related gene functional enrichment analysis) was applied to study the expression profile, clinical relationship, prognostic significance and immune infiltration of ING in LIHC. The relationship between ING family genes expression and tumor associated immune checkpoints was investigated in LIHC. The molecular mechanism of ING1 mediated hepatocarcinogenesis was preliminarily discussed.
RESULTS
mRNA/protein expression of different ING family genes in LIHC was analyzed in different databases, showing that ING family genes were highly expressed in LIHC. In 47 samples from 366 LIHC patients, the ING family genes were altered at a rate of 13%. By comprehensively analyzing the expression, clinical pathological parameters and prognostic value of ING family genes, ING1/5 was identified. ING1/5 was related to poor prognosis of LIHC, suggesting that they may play key roles in LIHC tumorigenesis and progression. One of the target miRNAs of ING1 was identified as hsa-miR-214-3p. Two upstream lncRNAs of hsa-miR-214-3p, U91328.1, and HCG17, were identified. At the same time, we found that the expression of ING family genes was correlated with immune cell infiltration and immune checkpoint genes.
CONCLUSION
This study lays a foundation for further research on the potential mechanism and clinical value of ING family genes in the treatment and prognosis of LIHC.