bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examination of factors affecting freeway incident clearance times: a comparison of the generalized F model and several alternative nested models
Authors: Ghosh Indrajit , Savolainen Peter T. , Gates Timothy J. 
Published: April 2012

ABSTRACTTraffic incidents are a principal cause of congestion on urban freeways, reducing capacity and creating risks for both involved motorists and incident response personnel. As incident durations increase, the risk of secondary incidents or crashes also becomes problematic. In response to these issues, many road agencies in metropolitan areas have initiated incident management programs aimed at detecting, responding to, and clearing incidents to restore freeways to full capacity as quickly and safely as possible. This study examined those factors that impact the time required by the Michigan Department of Transportation Freeway Courtesy Patrol to clear incidents that occurred on the southeastern Michigan freeway network. These models were developed using traffic flow data, roadway geometry information, and an extensive incident inventory database. A series of parametric hazard duration models were developed, each assuming a different underlying probability distribution for the hazard function. Although each modeling framework provided results that were similar in terms of the direction of factor effects, there was significant variability in terms of the estimated magnitude of these impacts. The generalized F distribution was shown to provide the best fit to the incident clearance time data, and the use of poorer fitting distributions was shown to result in severe over‐estimation or under‐estimation of factor effects. Those factors that were found to impact incident clearance times included the time of day and month when the incident occurred, the geometric and traffic characteristics of the freeway segment, and the characteristics of each incident. Copyright © 2012 John Wiley & Sons, Ltd.
Molecular signatures from omics data: From chaos to consensus
Authors: Sung Jaeyun , Wang Yuliang , Chandrasekaran Sriram , Witten Daniela M. , Price Nathan D. 
Published: April 2012

AbstractIn the past 15 years, new “omics” technologies have made it possible to obtain high‐resolution molecular snapshots of organisms, tissues, and even individual cells at various disease states and experimental conditions. It is hoped that these developments will usher in a new era of personalized medicine in which an individual's molecular measurements are used to diagnose disease, guide therapy, and perform other tasks more accurately and effectively than is possible using standard approaches. There now exists a vast literature of reported “molecular signatures”. However, despite some notable exceptions, many of these signatures have suffered from limited reproducibility in independent datasets, insufficient sensitivity or specificity to meet clinical needs, or other challenges. In this paper, we discuss the process of molecular signature discovery on the basis of omics data. In particular, we highlight potential pitfalls in the discovery process, as well as strategies that can be used to increase the odds of successful discovery. Despite the difficulties that have plagued the field of molecular signature discovery, we remain optimistic about the potential to harness the vast amounts of available omics data in order to substantially impact clinical practice.
Ca2+‐induced binding of anticoagulation factor II from the venom of Agkistrodon acutus with factor IX
Authors: Shen Deng‐Ke , Xu Xiao‐Long , Zhang Yan , Song Jia‐Jia , Yan Xin‐Cheng , Guo Ming‐Chun 
Published: April 2012

AbstractAnticoagulation factor II (ACF II), a coagulation factor X‐ binding protein from the venom of Agkistrodon acutus has both anticoagulant and hypotensive activities. Previous studies show that ACF II binds specifically with activated factor X (FXa) in a Ca2+‐dependent manner and inhibits intrinsic coagulation pathway. In this study, the inhibition of extrinsic coagulation pathway by ACF II was measured in vivo by prothrombin time assay and the binding of ACF II to factor IX (FIX) was investigated by native polyacrylamide gel electrophoresis and surface plasmon resonance (SPR). The results indicate that ACF II also inhibits extrinsic coagulation pathway, but does not inhibit thrombin activity. ACF II also binds with FIX with high binding affinity in a Ca2+‐dependent manner and their maximal binding occurs at about 0.1 mM Ca2+. ACF II has similar binding affinity to FIX and FX as determined by SPR. Ca2+ has a slight effect on the secondary structure of FIX as determined by circular dichroism spectroscopy. Ca2+ ions are required to maintain in vivo function of FIX Gla domain for its recognition of ACF II. However, Ca2+ at high concentrations (>0.1 mM) inhibits the binding of ACF II to FIX. Ca2+ functions as a switch for the binding between ACF II and FIX. ACF II extends activated partial thromboplastin time more strongly than prothrombin time, suggesting that the binding of ACF II with FIX may play a dominant role in the anticoagulation of ACF II in vivo. © 2012 Wiley Periodicals, Inc. Biopolymers 97: 818–824, 2012.
Easy alignment and effective nucleation activity of ramie fibers in injection‐molded poly(lactic acid) biocomposites
Authors: Xu Huan , Liu Chun‐Yan , Chen Chen , Hsiao Benjamin S. , Zhong Gan‐Ji , Li Zhong‐Ming 
Published: April 2012

AbstractThe poly(lactic acid) (PLA)/ramie fiber biocomposites were fabricated, which exhibited considerable reinforcement effect comparable to the glass fiber at the same loading. The attempts were made to understand the flow‐induced morphology of ramie fibers and PLA crystals in the injection‐molded PLA/ramie fiber biocomposites, thus revealing its relationship to biocomposite mechanical properties. The polarized optical microscopy (POM) and two‐dimensional wide‐angle X‐ray diffraction (2D‐WAXD) were for the first time used to determine the distribution of nature fibers, which interestingly showed the ramie fibers aligned well along the flow direction over the whole thickness of injection‐molded parts, instead of skin‐core structure. This easy alignment of ramie fibers during the common processing was ascribed to the intrinsically high flexibility of ramie fibers and strong interfacial interaction between PLA chains and cellulose molecules of ramie fibers. Both 2D‐WAXD and differential scanning calorimeter (DSC) measurements suggested that the PLA matrix in its ramie biocomposites had rather high orientation degree and crystallinity, which was attributed to effective heterogeneous nucleation induced by ramie fibers and local shearing field in the vicinity of fiber surface. Remarkable improvement of mechanical and thermo‐mechanical properties was achieved for PLA/ramie fiber biocomposites, without sacrifice of toughness and ductility. Addition of 30wt% ramie fibers increased the tensile strength and modulus of PLA/ramie fiber biocomposites from 65.6 and 1468 MPa for pure PLA to 91.3 and 2977 MPa, respectively. These superior mechanical properties were ascribed to easy alignment of ramie fibers, high crystallinity of PLA, and favorable interfacial adhesion as revealed by scanning electron microscopy (SEM) observation and theoretical analysis based on dynamic mechanical analysis (DMA) data. © 2012 Wiley Periodicals, Inc. Biopolymers 97: 825–839, 2012.
ChemInform Abstract: Phase Formation in the Li2MoO4—K2MoO4 —In2(MoO4)3 System and Crystal Structures of New Compounds K3InMo4O15 and LiK2In(MoO4)3.
Authors: Khal'baeva Klara M. , Solodovnikov Sergey F. , Khaikina Elena G. , Kadyrova Yuliya M. , Solodovnikova Zoya A. , Basovich Olga M. 
Published: April 2012

AbstractPhase formation in the title system is investigated and the crystal structures of the new compounds K3InMo4O15 (I) and LiK2In(MoO4)3 (II) are determined by single crystal XRD.
ChemInform Abstract: Syntheses and Crystal Structures of Two Novel Alkaline Uranyl Chromates A2(UO2)(CrO4)2 (A: Rb, Cs) with Bidentate Coordination Mode of Uranyl Ions by Chromate Anions.
Authors: Siidra Oleg I. , Nazarchuk Evgeny V. , Krivovichev Sergey V. 
Published: April 2012

AbstractSingle yellow‐green crystals of the title compounds are prepared by solid state reactions of 2:3:1 mixtures of MNO3 (M: Rb, Cs), CrO3, and UO2(NO3)2 (air, 270 °C, Pt crucible, 10 h).
ChemInform Abstract: Condensation of 2,6‐Diarylmethylidenecyclohexa(penta)nones with Acetylacetone and Ethyl Acetoacetate.
Authors: Gulai T. V. , Morozova A. A. , Golikov A. G. 
Published: April 2012

AbstractThe reactions result in formation of products of carbo‐ and heterocyclization.
ChemInform Abstract: SN2‐Type Ring Opening of Substituted‐N‐tosylaziridines with Zinc(II) Halides: Control of Racemization by Quaternary Ammonium Salt.
Authors: Ghorai Manas K. , Tiwari Deo Prakash , Kumar Amit , Das Kalpataru 
Published: April 2012

AbstractA simple method for the synthesis of racemic and non‐racemic β‐halo amines via the ring‐opening of N‐tosyl aziridines with Zn(II) halides is developed.
ChemInform Abstract: Microwave‐Assisted Meyer—Schuster Rearrangement of Propargylic Alcohols Catalyzed by the Oxovanadate Complex [V(O)Cl(OEt)2].
Authors: Antinolo Antonio , Carrillo‐Hermosilla Fernando , Cadierno Victorio , Garcia‐Alvarez Joaquin , Otero Antonio 
Published: April 2012

AbstractA variety of both terminal and internal alkynols is isomerized using the readily accessible vanadate complex.
ChemInform Abstract: Reduction of Aromatic and Aliphatic Esters Using the Reducing Systems MoO2(acac)2 or V(O)(OiPr)3 in Combination with 1,1,3,3‐Tetramethyldisiloxane.
Authors: Pehlivan Leyla , Metay Estelle , Laval Stephane , Dayoub Wissam , Delbrayelle Dominique , Mignani Gerard , Lemaire Marc 
Published: April 2012

AbstractThe present new and efficient reduction of aromatic and aliphatic esters employes 1,1,3,3‐tetramethyldisiloxane as reducing agent to give the corresponding alcohols.
ChemInform Abstract: Indium‐Mediated Asymmetric Barbier‐Type Propargylations: Additions to Aldehydes and Ketones and Mechanistic Investigation of the Organoindium Reagents.
Authors: Haddad Terra D. , Hirayama Lacie C. , Buckley Jannise , Singaram Bakthan 
Published: April 2012

AbstractIn the presence of In, Py, and the amino alcohol ADPE, propargyl bromide (II) undergoes efficient enantioselective addition to various aldehydes to afford optically active homopropargylic alcohols.
ChemInform Abstract: Synthesis of Water‐Soluble Monotosylated Ethylenediamines and Their Application in Ruthenium and Iridium‐Catalyzed Transfer Hydrogenation of Aldehydes.
Authors: Zhou Zhongqiang , Ma Qiong , Zhang Aiqing , Wu Lamei 
Published: April 2012

AbstractThree title salts are prepared and tested in the presence of Ru and Ir catalyst.
ChemInform Abstract: Palladium‐Catalyzed Allylic Alkylation of Carboxylic Acid Derivatives: N‐Acyloxazolinones as Ester Enolate Equivalents.
Authors: Trost Barry M. , Michaelis David J. , Charpentier Julie , Xu Jiayi 
Published: April 2012

AbstractAn optimized method for the synthesis of the enol‐carbonate substrates is elaborated.
ChemInform Abstract: A Highly Efficient Method for the Copper‐Catalyzed Selective Synthesis of Diaryl Chalcogenides from Easily Available Chalcogen Sources.
Authors: Li Yaming , Nie Caiping , Wang Huifeng , Li Xiaoying , Verpoort Francis , Duan Chunying 
Published: April 2012

AbstractSymmetrical diaryl chalcogenides and unsymmetrical diarylsulfides are synthesized by the present newly developed method using Na2S or selenium powder as chalcogen sources.
ChemInform Abstract: Synthesis and Properties of Unsymmetrical N,N′‐Dialkylterrylenebis(dicarboximide) Derivatives and Their Related Derivatives.
Authors: Nagao Yukinori , Iwano Tomohiro , Hirano Maki , Arimitsu Koji , Kozawa Kozo 
Published: April 2012

AbstractSome of the terrylene derivatives synthesized, e.g. (VIc), behave as n‐type semiconductor for a Schottky device.
ChemInform Abstract: An Efficient Synthesis of (R)‐3‐Aminothiolane.
Authors: Pan Xianhua , Tao Xiaohu , Ruan Libo , Li Yiming , Ou Wenhua , Liu Feng 
Published: April 2012

Abstract(R)‐(VI) [based on a one‐pot tandem hydroxyl activation—intramolecular cyclization of Tos‐protected D‐methioninol (IV)].
ChemInform Abstract: An Approach to the Stereoselective Synthesis of Enantiopure Dihydropyrroles and Aziridines from a Common Sulfinyl‐Sulfinamide Intermediate.
Authors: Viso Alma , Fernandez de la Pradilla Roberto , Urena Mercedes , Bates Robert H. , del Aguila Miguel A. , Colomer Ignacio 
Published: April 2012

AbstractAddition of chiral sulfinimines to vinylic sulfoxides results in stereoselective formation of the synthetic intermediates (III).
ChemInform Abstract: Synthesis and in vivo Evaluation of Carbonyl‐amide Linkage Based New Benzimidazole Derivatives.
Authors: Shaikh Irfan N. , Hosamani Kallappa M. , Seetharamareddy Harisha R. , Hugar Mallinath H. 
Published: April 2012

AbstractThe title compounds (IV) are obtained via Passerini reaction from acetic acid (I), aromatic aldehydes (II), and isocyanide (III).
ChemInform Abstract: Stereoselective, One‐Pot, Three‐Component Synthesis of 4‐Aryltetrahydropyrans from Epoxides via Prins Cyclization Reaction.
Authors: Indukuri Kiran , Bondalapati Somasekhar , Kotipalli Trimurtulu , Gogoi Paramartha , Saikia Anil K. 
Published: April 2012

AbstractThe reaction involves a Prins cyclization and Friedel—Crafts cycloaddition to afford all‐cis diastereomers.
ChemInform Abstract: Rhodium‐Catalyzed Enantioselective Synthesis of 4‐Arylchroman‐2‐ones.
Authors: Allen Joseph C. , Kociok‐Koehn Gabriele , Frost Christopher G. 
Published: April 2012

AbstractThe use of stable silyl‐protected dioxaborinanes as donors in the 1,4‐addition to arylidene Meldrum′s acids as acceptors is found to be advantageous to achieve good yields under anhydrous conditions.
ChemInform Abstract: Vilsmeier‐Type Reaction of Dimethylaminoalkenoyl Cyclopropanes: One‐Pot Access to 2,3‐Dihydrofuro[3,2‐c]pyridin‐4(5H)‐ones.
Authors: Huang Peng , Zhang Ning , Zhang Rui , Dong Dewen 
Published: April 2012

AbstractStarting from cyclopropane substrates, the desired ring system is formed via tandem formylation, intramolecular cyclization and ring enlargement.
ChemInform Abstract: Regioselective Synthesis of 2,8‐Disubstituted 4‐Aminopyrido[3,2‐d]pyrimidine‐6‐carboxylic Acid Methyl Ester Compounds.
Authors: Bouscary‐Desforges Gwenaelle , Bombrun Agnes , Augustine John Kallikat , Bernardinelli Gerald , Quattropani Anna 
Published: April 2012

AbstractThe use of appropriate conditions and reagents allows regioselective formation of a number of differently substituted pyridopyrimidines.
ChemInform Abstract: New Substituted C‐19‐Andrographolide Analogues with Potent Cytotoxic Activities.
Authors: Sirion Uthaiwan , Kasemsook Sakkasem , Suksen Kanoknetr , Piyachaturawat Pawinee , Suksamrarn Apichart , Saeeng Rungnapha 
Published: April 2012

AbstractA series of andrographolide analogues is synthesized by modification at the three hydroxyl groups of the natural andrographolide, the major diterpenoid lactone from Andrographis paniculata.
ChemInform Abstract: Synthesis of Novel Difluoro‐Cyclopropyl Guanine Nucleosides and Their Phosphonate Analogues as Potent Antiviral Agents.
Authors: Li Hua , Yoo Jin Cheol , Kim Eunae , Hong Joon Hee 
Published: April 2012

AbstractNovel phosphonate (XIII) demonstrates promising anti‐HIV‐1 activity in vitro, whilst new nucleoside analogue (XIV) displays moderate antiviral activity against human cytomegalovirus in MRC cells.
The influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival
Authors: Saeed Ali M. , Toonkel Rebecca , Glassberg Marilyn K. , Nguyen Dao , Hu Jennifer J. , Zimmers Teresa A. , Robbins David J. , Koniaris Leonidas G. , Lally Brian E. 
Published: April 2012

AbstractBACKGROUND:Most studies exploring ethnic/racial disparities in nonsmall cell lung cancer (NSCLC) compare black patients with whites. Currently, the effect of Hispanic ethnicity on the overall survival of NSCLC is poorly understood. Therefore, the authors carried out a large‐scale, population‐based analysis using the Surveillance, Epidemiology, and End Results (SEER) data base to determine the impact of Hispanic ethnicity the survival of patients with NSCLC.METHODS:The authors identified 172,398 adult patients with pathologically confirmed NSCLC from the SEER data base who were diagnosed between 1988 and 2007. A multivariate Cox proportional hazards regression analysis was used to determine the impact of race/ethnicity on overall survival. Pair‐wise comparisons were used to determine whether Hispanic ethnicity influenced NSCLC histology or stage at diagnosis.RESULTS:Compared with non‐Hispanic white patients, Hispanic white patients had a statistically significant better overall survival (hazard ratio [HR], 0.85; 95% confidence interval [CI], 0.83‐0.87), and black patients had worse survival (HR, 1.091; 95% CI, 1.072‐1.109). Within the bronchioalveolar carcinoma (BAC) subtype, Hispanic‐white patients tend to be over represented (8.1% Hispanic whites vs 5.5% non‐Hispanic whites vs 3.7% blacks; P < .001).CONCLUSIONS:The current study demonstrated that Hispanic‐white patients with NSCLC had a decreased risk for overall mortality compared with non‐Hispanic whites and blacks. Moreover, Hispanic patients were over represented within the BAC histologic subtype. Thus, the overall survival advantage of Hispanic NSCLC patients may be because of their predilection toward developing certain histologic subtypes of NSCLC. Further studies are warranted to determine the etiologies of such predilections and may reveal certain genetic, environmental, and/or epigenetic factors associated with Hispanic ethnicity. Cancer 2012. © 2012 American Cancer Society.
Clinical and pathologic features and clinical impact of false negative thyroid fine‐needle aspirations
Authors: Jean‐Gilles Jerome , Fischer Andrew H. , Luu Martin H. , Owens Christopher L. 
Published: April 2012

AbstractBACKGROUND:Although thyroid fine‐needle aspiration (TFNA) is an excellent test in evaluating thyroid nodules, there are occasionally false negatives (FN). The clinical impact and pathologic features of FN TFNA is understudied in the peer‐reviewed literature.METHODS:A cohort of patients with thyroid cancer was separated into those with referring FN TFNA and those with referring true positive (TP) TFNA. Preoperative characteristics, pathologic finding, and clinical outcomes were compared within the 2 groups.RESULTS:A total of 192 patients with TP TFNA (n = 162) and FN TFNA (n = 30) were included in the study. There were no significant differences in the demographics or length of follow‐up of the 2 groups. The FN TFNA group was more likely to have a larger clinical nodule size and experienced a significant delay from initial TFNA to surgery. The FN TFNA group was more likely to be diagnosed with the follicular variant of papillary thyroid cancer (73.3% vs 25.9%, P < .001), less likely to have positive lymph nodes at surgery (6.7% vs 35.8%, P = .001), and more likely to undergo 2‐step surgery (30% vs 9.9%, P = .007). Despite the delay in diagnosis, persistent/recurrent or metastatic disease, incidence of aggressive histologic variants, and pT4 disease was not different in the 2 groups.CONCLUSIONS:The clinical impact of FN TFNA at our high‐volume center is minimal. Cancers in this setting are low grade, and outcomes are not adversely affected despite the delay in diagnosis. Cancer (Cancer Cytopathol) 2012. © 2012 American Cancer Society.
Systematic mapping of fragile X granules in the mouse brain reveals a potential role for presynaptic FMRP in sensorimotor functions
Authors: Akins Michael R. , LeBlanc Hannah F. , Stackpole Emily E. , Chyung Eunice , Fallon Justin R. 
Published: April 2012

AbstractLoss of Fragile X mental retardation protein (FMRP) leads to Fragile X syndrome (FXS), the most common form of inherited intellectual disability and autism. Although the functions of FMRP and its homologs FXR1P and FXR2P are well studied in the somatodendritic domain, recent evidence suggests that this family of RNA binding proteins also plays a role in the axonal and presynaptic compartments. Fragile X granules (FXGs) are morphologically and genetically defined structures containing Fragile X proteins that are expressed axonally and presynaptically in a subset of circuits. To further understand the role of presynaptic Fragile X proteins in the brain, we systematically mapped the FXG distribution in the mouse central nervous system. This analysis revealed both the circuits and the neuronal types that express FXGs. FXGs are enriched in circuits that mediate sensory processing and motor planning—functions that are particularly perturbed in FXS patients. Analysis of FXG expression in the hippocampus suggests that CA3 pyramidal neurons use presynaptic Fragile X proteins to modulate recurrent but not feedforward processing. Neuron‐specific FMRP mutants revealed a requirement for neuronal FMRP in the regulation of FXGs. Finally, conditional FMRP ablation demonstrated that FXGs are expressed in axons of thalamic relay nuclei that innervate cortex, but not in axons of thalamic reticular nuclei, striatal nuclei, or cortical neurons that innervate thalamus. Together, these findings support the proposal that dysregulation of axonal and presynaptic Fragile X proteins contribute to the neurological symptoms of FXS. J. Comp. Neurol. 520:3687–3706, 2012. © 2012 Wiley Periodicals, Inc.
Differential expression of components of the retinoic acid signaling pathway in the adult mouse olfactory epithelium
Authors: Peluso Carolyn E. , Jang Woochan , Dräger Ursula C. , Schwob James E. 
Published: April 2012

AbstractPosition within a tissue often correlates with cellular phenotype, for example, differential expression of odorant receptors and cell adhesion molecules across the olfactory mucosa (OM). The association between position and phenotype is often paralleled by gradations in the concentration of retinoic acid (RA), caused by differential expression of the RA synthetic enzymes, the retinaldehyde dehydrogenases (RALDH). We show here that RALDH‐1, ‐2, and ‐3 are enriched in the sustentacular cells, deep fibroblasts of the lamina propria, and the superficial fibroblasts, respectively, of the ventral and lateral OM as compared to the dorsomedial OM. The shift from high to low expression of the RALDHs matches the boundary defined by the differential expression of OCAM/mamFasII. Further, we found that RA‐binding proteins are expressed in the epithelium overlying the RALDH‐3 expressing fibroblasts of the lamina propria. Both findings suggest that local alterations in RA concentration may be more important than a gradient of RA across the epithelial plane, per se. In addition, RALDH‐3 is found in a small population of basal cells in the ventral and lateral epithelium, which expand and contribute to the neuronal lineage following MeBr lesion. Indeed, transduction with a retrovirus expressing a dominant negative form of retinoic acid receptor type alpha blocks the reappearance of mature, olfactory marker protein (OMP) (+) olfactory neurons as compared to empty vector. These results support the notion of a potential role for RA, both in maintaining the spatial organization of the normal olfactory epithelium and in reestablishing the neuronal population during regeneration after injury. J. Comp. Neurol. 520:3707–3726, 2012. © 2012 Wiley Periodicals, Inc.