bluuebunny/crossref_metadata_2025_split huggingface dataset:
VX‐765 alleviates motor and cognitive impairments via inhibiting PANoptosis activation in the neonatal rats after hypoxic–ischemic brain damage
Authors: Li Xiaohuan , Chen Mulan , Xu Boqing , Fan Yepeng , Dai Chunfang , Dong Zhifang 
Published: May 2024

AbstractNeonatal hypoxia–ischemia (HI) is one of the main factors that cause neonatal severe neurologic impairment and death. Shown by a large number of studies, caspase‐1 plays a significant effect in diseases such as hypoxic–ischemic brain damage (HIBD) and may be a key component of the protein complex that initiates PANoptosis. VX‐765, an inhibitor of caspase‐1, exerts a potential neuroprotective effect in traumatic brain injury. However, it is unknown whether the administration of VX‐765 has neuroprotective effects on neonatal rats that suffered HIBD, and if so, the underlying mechanisms are also still unknown. In the present study, we found that treatment with VX‐765 (50 mg/kg, i.p.) significantly ameliorated the impairment of locomotor coordination functions and myodynamia as well as the spatial learning and memory in neonatal rats subjected with HIBD. These behavior improvements were attributed to VX‐765 reducing infarct volumes and neuronal loss in the CA1, CA3 region of hippocampus, and deeper layers of the cortex in HIBD rats. Moreover, the enzyme‐linked immunosorbent assay showed that VX‐765 obviously decreased the production of neuroinflammatory factors including TNF‐α, IL‐1β, and IL‐6. Importantly, we identified HI promoted PANoptosis activation in vivo and in vitro, and VX‐765 obviously suppressed PANoptosis activation. Finally, we demonstrated that VX‐765 treatment reversed neuronal injury induced by oxygen–glucose deprivation (OGD). Taken together, these results suggest that VX‐765 protects the neurons against damage by suppressing neuroinflammation and PANoptosis activation, thereby improving locomotor coordination and cognitive impairments in neonatal HIBD rats, indicating that VX‐765 may be an underlying therapeutic drug for the clinical treatment of hypoxic–ischemic encephalopathy (HIE).
Early bedside detection of pulmonary perfusion defect by electrical impedance tomography after pulmonary endarterectomy
Authors: Wang Qianlin , He Huaiwu , Yuan Siyi , Jiang Jing , Chi Yi , Long Yun , Zhao Zhanqi 
Published: May 2024

AbstractPulmonary endarterectomy (PEA) is the standard treatment for chronic thromboembolic pulmonary hypertension. However, it poses risks of perioperative vascular complications, which can lead to serious clinical outcomes. This study introduces a novel noninvasive and radiation‐free clinical imaging tool, electrical impedance tomography (EIT), for real‐time bedside assessment of lung perfusion after PEA. It identifies ventilation‐perfusion mismatches arising from postoperative complications, particularly valuable for patients with hemodynamic instability, thus eliminating risks tied to CT room transfers. The article reports a case where EIT was used to identify an in‐situ thrombosis post‐PEA, marking the first such application. The emphasis is on early detection using EIT, which offers a promising approach for therapeutic interventions and improved postoperative evaluations.
Polyglycerol‐Functionalized β‐Cyclodextrins as Crosslinkers in Thermoresponsive Nanogels for the Enhanced Dermal Penetration of Hydrophobic Drugs
Authors: Wang Huiyi , Tiwari Neha , Orellano Maria Soledad , Navarro Lucila , Beiranvand Zahra , Adeli Mohsen , Calderón Marcelo 
Published: May 2024

AbstractThermoresponsive nanogels (tNGs) are promising candidates for dermal drug delivery. However, poor incorporation of hydrophobic drugs into hydrophilic tNGs limits the therapeutic efficiency. To address this challenge, β‐cyclodextrins (β‐CD) are functionalized by hyperbranched polyglycerol serving as crosslinkers (hPG‐βCD) to fabricate βCD‐tNGs. This novel construct exhibits augmented encapsulation of hydrophobic drugs, shows the appropriate thermal response to dermal administration, and enhances the dermal penetration of payloads. The structural influences on the encapsulation capacity of βCD‐tNGs for hydrophobic drugs are analyzed, while concurrently retaining their efficacy as skin penetration enhancers. Various synthetic parameters are considered, encompassing the acrylation degree and molecular weight of hPG‐βCD, as well as the monomer composition of βCD‐tNGs. The outcome reveals that βCD‐tNGs substantially enhance the aqueous solubility of Nile Red elevating to 120 µg mL−1 and augmenting its dermal penetration up to 3.33 µg cm−2. Notably, the acrylation degree of hPG‐βCD plays a significant role in dermal drug penetration, primarily attributed to the impact on the rigidity and hydrophilicity of βCD‐tNGs. Taken together, the introduction of the functionalized β‐CD as the crosslinker in tNGs presents a novel avenue to enhance the efficacy of hydrophobic drugs in dermatological applications, thereby offering promising opportunities for boosted therapeutic outcomes.
ROS‐Responsive and Self‐Tumor Curing Methionine Polymer Library Based Nanoparticles with Self‐Accelerated Drug Release and Hydrophobicity/Hydrophilicity Switching Capability for Enhanced Cancer Therapy
Authors: Liu Jie , You Xinru , Wang Liying , Zeng Jianwen , Huang Hai , Wu Jun 
Published: May 2024

AbstractThe applications of amino acid‐based polymers are impeded by their limited structure and functions. Herein, a small library of methionine‐based polymers (Met‐P) with programmed structure and reactive oxygen species (ROS)‐responsive properties is developed for tumor therapy. The Met‐P can self‐assemble into sub‐100 nm nanoparticles (NPs) and effectively load anticancer drugs (such as paclitaxel (PTX) (P@Met‐P NPs)) via the nanoprecipitation method. The screened NPs with superior stability and high drug loading are further evaluated in vitro and in vivo. When encountering with ROS, the Met‐P polymers will be oxidized and then switch from a hydrophobic to a hydrophilic state, triggering the rapid and self‐accelerated release of PTX. The in vivo results indicated that the screened P@2Met10 NPs possessed significant anticancer performance and effectively alleviated the side effects of PTX. More interestingly, the blank 2Met10 NPs displayed an obvious self‐tumor inhibiting efficacy. Furthermore, the other Met‐P NPs (such as 2Met8, 4Met8, and 4Met10) are also found to exhibit varied self‐anti‐cancer capabilities. Overall, this ROS‐responsive Met‐P library is a rare anticancer platform with hydrophobic/hydrophilic switching, controlled drug release, and self‐anticancer therapy capability.
Cancer Nanovaccines: Nanomaterials and Clinical Perspectives
Authors: Desai Nimeet , Chavda Vivek , Singh Thakur Raghu Raj , Thorat Nanasaheb D. , Vora Lalitkumar K. 
Published: May 2024

AbstractCancer nanovaccines represent a promising frontier in cancer immunotherapy, utilizing nanotechnology to augment traditional vaccine efficacy. This review comprehensively examines the current state‐of‐the‐art in cancer nanovaccine development, elucidating innovative strategies and technologies employed in their design. It explores both preclinical and clinical advancements, emphasizing key studies demonstrating their potential to elicit robust anti‐tumor immune responses. The study encompasses various facets, including integrating biomaterial‐based nanocarriers for antigen delivery, adjuvant selection, and the impact of nanoscale properties on vaccine performance. Detailed insights into the complex interplay between the tumor microenvironment and nanovaccine responses are provided, highlighting challenges and opportunities in optimizing therapeutic outcomes. Additionally, the study presents a thorough analysis of ongoing clinical trials, presenting a snapshot of the current clinical landscape. By curating the latest scientific findings and clinical developments, this study aims to serve as a comprehensive resource for researchers and clinicians engaged in advancing cancer immunotherapy. Integrating nanotechnology into vaccine design holds immense promise for revolutionizing cancer treatment paradigms, and this review provides a timely update on the evolving landscape of cancer nanovaccines.
Sea Anemone‐Inspired Slippery Liquid‐Infused Porous Surface (SLIPS) with Bionic Cilia for Responsive 4D Antifouling
Authors: Tong Zheming , Zhang Shen , Chen Sifan , Sun Rui , He Peng , Song Lina , Hu Jiankun , Hou Yang , Zhan Xiaoli , Zhang Qinghua 
Published: May 2024

AbstractThe formation process of biofouling is actually a 4D process with both spatial and temporal dimensions. However, most traditional antifouling coatings, including slippery liquid‐infused porous surface (SLIPS), are limited to performing antifouling process in the 2D coating plane. Herein, inspired by the defensive behavior of sea anemones’ wielding toxic tentacles, a “4D SLIPS” (FSLIPS) is constructed with biomimetic cilia via a magnetic field self‐assembly method for antifouling. The bionic cilia move in 3D space driven by an external magnetic field, thereby preventing the attachment of microorganisms. The FSLIPS releases the gaseous antifoulant (nitric oxide) at 1D time in response to light, thereby achieving a controllable biocide effect on microorganisms. The FSLIPS regulates the movement of cilia via the external magnetic field, and controls the release of NO overtime via the light response, so as to adjust the antifouling modes on demand during the day or night. The light/magnetic response mechanism endow the FSLIPS with the ability to adjust the antifouling effect in the 4D dimension of 1D time and 3D space, effectively realizing the intelligence, multi‐dimensionality and precision of the antifouling process.
Reversible Switching Between Microwave Absorption and EMI Shielding of VO2 Composite Foam
Authors: Liao Si‐Yuan , Wang Xiao‐Yun , Shi Yu‐Ying , Wang Qiao‐Feng , Gu Xin‐Yin , Hu You‐Gen , Zhu Peng‐Li , Sun Rong , Wan Yan‐Jun 
Published: May 2024

AbstractDeveloping lightweight composite with reversible switching between microwave (MW) absorption and electromagnetic interference (EMI) shielding is promising yet remains highly challenging due to the completely inconsistent attenuation mechanism for electromagnetic (EM) radiation. Here, a lightweight vanadium dioxide/expanded polymer microsphere composites foam (VO2/EPM) is designed and fabricated with porous structures and 3D VO2 interconnection, which possesses reversible switching function between MW absorption and EMI shielding under thermal stimulation. The VO2/EPM exhibits MW absorption with a broad effective absorption bandwidth of 3.25 GHz at room temperature (25 °C), while provides EMI shielding of 23.1 dB at moderately high temperature (100 °C). This reversible switching performance relies on the porous structure and tunability of electrical conductivity, complex permittivity, and impedance matching, which are substantially induced by the convertible crystal structure and electronic structure of VO2. Finite element simulation is employed to qualitatively investigate the change in interaction between EM waves and VO2/EPM before and after the phase transition. Moreover, the application of VO2/EPM is demonstrated with a reversible switching function in controlling wireless transmission on/off, showcasing its excellent cycling stability. This kind of smart material with a reversible switching function shows great potential in next‐generation electronic devices.
Hydrindacene‐Based Zinc Aryl Thiolate and Aryl Selenolate Zn(EMSFluind)2 (E=S, Se)
Authors: Komorr Pascal , Puylaert Pim , Beckmann Jens 
Published: May 2024

AbstractThe bulky aryl thiol, MSFluindSH (1S), and aryl selenol, MSFluindSeH (1Se), possessing a tetramethyl‐s‐hydrindacen‐4’‐yl‐(Rind)‐based substituent containing two fluorenyl groups in 9 and 9’‐positions, were prepared (MSFluind=dispiro[fluorene‐9,3’‐(1’,1’,7’,7’‐tetramethyl‐s‐hydrindacene‐4’‐yl)‐5’,9’’‐fluorene]). The reaction of 1S and 1Se with Et2Zn provided a monomeric zinc aryl thiolate, Zn(SMSFluind)2 (2S), and zinc aryl selenolate, Zn(SeMSFluind)2 (2Se), with essentially two‐coordinate zinc atoms.
Stuck in the Suburbs? Socio-spatial Exclusion of Migrants in Shanghai
Authors: Shen Jie 
Published: May 2024

AbstractMigrants’ residential location plays a critical role in their social integration process. In China, large numbers of rural-to-urban migrants are coming to the major cities for the opportunities they offer, and most of these migrants have to settle in the disadvantaged urban periphery. By examining the place effects of suburban residence on the incorporation of migrants into cities, this paper contributes to the literature on understanding the socio-spatial exclusion of migrants. Drawing on a survey undertaken in Shanghai, it is found that, after controlling for the effects of individual characteristics, migrants living in the suburbs not only earn less than their counterparts in the central city but are also less likely to construct inter-group and diverse social ties to aid prospects. To make matters worse, they have little chance of moving to the central locations where there are more resources and instead are likely to be trapped in the suburbs.
Conclusion
Authors: Cunningham Stuart , Davidson Jane W. , Blackler Alethea 
Published: May 2024

AbstractLet us start with two pieces of data, one from history and one from economics, and a deduction drawn from sociology and politics. The first, from 85 years ago, occurred when the judge presiding over an Australian Royal Commission into the devastating “Black Saturday” bushfires pronounced “We have not lived long enough”. What he meant was that European settlers in this country, Australia, had not learned how to live in a land characterised by climatic extremes of drought, fire and flood. The words echo in environmental historian Tom Griffiths’ “we have not yet lived long enough”, after his review of the long history of lack of preparedness for such events, despite the repetitiousness with which that lack of preparedness has issued forth from reports and enquiries too numerous to mention here. The second is the Productivity Commission’s (2014) finding that 97% of Australia’s public funds spent on disasters went to crisis management and recovery and only 3% on preparedness. What we might derive from these points is that “there is no such thing as a natural disaster” (Hartman & Squires, 2006). The history of Indigenous fire management over millennia, leading to early European settlers’ puzzlement over what appeared to be curated/estate like landscapes, underscores the fact that human preparedness and the lack of it are material factors in the severity and impact of any “natural” disaster, that is, if we may have lived long enough by now.
Immersive Visualisation Systems as Alignment Strategies for Extreme Event Scenarios
Authors: Brits Baylee , Song Yang , Tirado Cortes Carlos 
Published: May 2024

AbstractImmersive systems are increasingly used to train first responders and prepare communities for extreme climate events. This chapter considers alignment issues that arise in their development and discusses how they might be resolved—taking as case study the iFire system currently being designed at the iCinema Research Centre. We particularly focus on ways to maximise the two non-moral values that define the success of any such system as well as of associated climate science: accuracy and verisimilitude. Drawing on the work of Shepherd et al. (2018) and Sharples et al. (2016), we theorise the epistemic and situational challenges to arrive at these values. Exploring solutions already proposed through the related concepts of ‘storylines’ (Shepherd, 2019), ‘scenarios’ (Lempert, 2013) and ‘tales’ (Hazeleger et al., 2015), we show how iFire’s values may be maximised through composition strategies derived from these concepts. Using this approach, we explain how iFire may ‘simulate’ links between uncertainty and affect to enhance decision making in uncertain circumstances. Our key findings are that alignment strategies for iFire are best described as ‘interpretable’ (rather than ‘explainable’) and can be achieved through qualitative methods. These describe compositional strategies deployed by the user that support reflective management of uncertainty.
Special cubulation of strict hyperbolization
Authors: Lafont Jean-François , Ruffoni Lorenzo 
Published: May 2024

AbstractWe prove that the Gromov hyperbolic groups obtained by the strict hyperbolization procedure of Charney and Davis are virtually compact special, hence linear and residually finite. Our strategy consists in constructing an action of a hyperbolized group on a certain dual $\operatorname {CAT}(0)$
CAT
(
0
)
cubical complex. As a result, all the common applications of strict hyperbolization are shown to provide manifolds with virtually compact special fundamental group. In particular, we obtain examples of closed negatively curved Riemannian manifolds whose fundamental groups are linear and virtually algebraically fiber.
Predictive factors of 90-day mortality after curative hepatic resection for hepatocellular carcinoma: a western single-center observational study
Authors: Vaghiri Sascha , Lehwald-Tywuschik Nadja , Prassas Dimitrios , Safi Sami Alexander , Kalmuk Sinan , Knoefel Wolfram Trudo , Dizdar Levent , Alexander Andrea 
Published: May 2024

Abstract
Purpose
The aim of this study was to identify predictive risk factors associated with 90-day mortality after hepatic resection (HR) in hepatocellular carcinoma (HCC).

Methods
All patients undergoing elective resection for HCC from a single- institutional and prospectively maintained database were included. Multivariate regression analysis was conducted to identify pre- and intraoperative as well as histopathological predictive factors of 90-day mortality after elective HR.

Results
Between August 2004 and October 2021, 196 patients were enrolled (148 male /48 female). The median age of the study cohort was 68.5 years (range19-84 years). The rate of major hepatectomy (≥ 3 segments) was 43.88%. Multivariate analysis revealed patient age ≥ 70 years [HR 2.798; (95% CI 1.263–6.198); p = 0.011], preoperative chronic renal insufficiency [HR 3.673; (95% CI 1.598–8.443); p = 0.002], Child–Pugh Score [HR 2.240; (95% CI 1.188–4.224); p = 0.013], V-Stage [HR 2.420; (95% CI 1.187–4.936); p = 0.015], and resected segments ≥ 3 [HR 4.700; (95% 1.926–11.467); p = 0.001] as the major significant determinants of the 90-day mortality.

Conclusion
Advanced patient age, pre-existing chronic renal insufficiency, Child–Pugh Score, extended hepatic resection, and vascular tumor involvement were identified as significant predictive factors of 90-day mortality. Proper patient selection and adjustment of treatment strategies could potentially reduce short-term mortality.
The use of peptides for immunodiagnosis of human Chagas disease
Authors: Ribeiro Anna Julia , Silva Kamila Alves , Lopes Lucas da Silva , Resende Carlos Ananias Aparecido , Couto Carolina Alves Petit , Gandra Isadora Braga , Pereira Isabela Amorim Gonçalves , Barcelos Isabelle Caroline Dos Santos , Pereira Sabrina Paula , Xavier Sandra Rodrigues , Tavares Grasiele de Sousa Viera , Machado Juliana Martins , Da Paz Mariana Campos , Chávez-Fumagalli Miguel Angel , Coelho Eduardo Antonio Ferraz , Giunchetti Rodolfo Cordeiro , Chaves Ana Thereza , Dutra Walderez Ornelas , Gonçalves Ana Alice Maia , Galdino Alexsandro Sobreira 
Published: May 2024

AbstractChagas disease, caused by the protozoa Trypanosoma cruzi, continues to be a serious public health problem in Latin America, worsened by the limitations in its detection. Given the importance of developing new diagnostic methods for this disease, the present review aimed to verify the number of publications dedicated to research on peptides that demonstrate their usefulness in serodiagnosis. To this end, a bibliographic survey was conducted on the PubMed platform using the keyword “peptide” or “epitope” combined with “Chagas disease” or “Trypanosoma cruzi”; “diagno*” or “serodiagnosis” or “immunodiagnosis”, without period restriction. An increasing number of publications on studies employing peptides in ELISA and rapid tests assays was verified, which confirms the expansion of research in this field. It is possible to observe that many of the peptides tested so far originate from proteins widely used in the diagnosis of Chagas, and many of them are part of commercial tests developed. In this sense, as expected, promising results were obtained for several peptides when tested in ELISA, as many of them exhibited sensitivity and specificity values above 90%. Furthermore, some peptides have been tested in several studies, confirming their diagnostic potential. Despite the promising results observed, it is possible to emphasize the need for extensive testing of peptides, using different serological panels, in order to confirm their potential. The importance of producing an effective assay capable of detecting the clinical stages of the disease, as well as new immunogenic antigens that enable new serological diagnostic tools for Chagas disease, is evident.
Outpatient glucocorticoid use and COVID-19 outcomes: a population-based study
Authors: Rodríguez-Fernández Almudena , Visos-Varela Irene , Zapata-Cachafeiro Maruxa , Pintos-Rodríguez Samuel , García-Álvarez Rosa M. , Herdeiro Teresa M. , Piñeiro-Lamas María , Figueiras Adolfo , Salgado-Barreira Ángel ,   COVIDRUG Group, Bugarín-González Rosendo , Carracedo-Martínez Eduardo , García-Álvarez Rosa M , González-Barcala Francisco J , Herdeiro Teresa M , Lema-Oreiro Martina , Mallah Narmeen , Piñeiro-Lamas Maria , Portela-Romero Manuel , Prieto-Campo Angela , Rodriguez-Fernández Almudena , Saez Marc , Salgado-Barreira Angel , Taracido-Trunk Margarita 
Published: May 2024

Abstract
Introduction
Owing to controversy information surrounds effect of glucocorticoids on the evolution of COVID-19, we evaluate the effects of outpatient glucocorticoid use on the severity and progression of COVID-19 and risk of infection and analyse the effect of window of exposure and dose.

Methods
We conducted a population-based case − control study, involving 4 substudies: (i) Hospitalisation; (ii) Mortality, using subjects hospitalised with a PCR + as cases and subjects without a PCR + as controls; (iii) Progression, including subjects with a PCR + (hospitalised versus non-hospitalised); and (iv) Susceptibility, with all subjects with a PCR + and subjects without a PCR + . Adjusted odds ratios (ORa) and their 95% confidence intervals (95% CI) were calculated.

Results
The outpatient glucocorticoid use was associated with an increased risk of hospitalisation (aOR 1.79; 95% CI 1.56–2.05), mortality (aOR 2.30; 95% CI 1.68–3.15), progression (aOR 1.69; 95% CI 1.43–2.00) and susceptibility (aOR 1.29, 95% CI 1.19–1.41). Furthermore, the effects was observed to be greater at higher doses and the closer that drug use approached the outcome date, with an almost fourfold increase in mortality among users in the previous month (aOR 3.85; 95% CI 2.63–5.62).

Conclusions
According to the results of this real-world data study, outpatient glucocorticoid use should be considered in making decisions about intrahospital treatment.