bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Technologies for Microfabricating Elastomeric Cardiac Tissue Engineering Scaffolds
Authors: Guillemette Maxime D. , Park Hyoungshin , Hsiao James C. , Jain Saloni R. , Larson Benjamin L. , Langer Robert , Freed Lisa E. 
Published: August 2010

AbstractPolymer scaffolds that direct elongation and orientation of cultured cells can enable tissue engineered muscle to act as a mechanically functional unit. We combined micromolding and microablation technologies to create muscle tissue engineering scaffolds from the biodegradable elastomer poly(glycerol sebacate). These scaffolds exhibited well defined surface patterns and pores and robust elastomeric tensile mechanical properties. Cultured C2C12 muscle cells penetrated the pores to form spatially controlled engineered tissues. Scanning electron and confocal microscopy revealed muscle cell orientation in a preferential direction, parallel to micromolded gratings and long axes of microablated anisotropic pores, with significant individual and interactive effects of gratings and pore design.magnified image
Isometric composition operators on BMOA
Authors: Laitila Jussi 
Published: August 2010

AbstractWe characterize and provide examples of the analytic self‐maps of the unit disc, which induce isometric com‐position operators on the space BMOA equipped with a Möbius invariant H2 norm (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Large time volume of the pinned Wiener sausage to second order
Authors: McGillivray I. 
Published: August 2010

AbstractWe investigate the large time behaviour of the expected volume of the pinned Wiener sausage associated to a compact subset K in \documentclass{article}\usepackage{amssymb}\pagestyle{empty}\begin{document}$ {\mathbb R}^d $\end{document} for d ⩾ 3. The structure of the asymptotic series is known: it depends strongly on whether the dimension d is odd or even; and the leading coefficient is given by the Newtonian capacity of K. In this article, we obtain detailed expressions for the second order coefficients. It is noteworthy that these coefficients feature novel potential‐theoretic terms that do not appear in the unpinned case. The proof exploits a trace formula of Krein. In the course of the argument, we derive a low‐energy expansion to second order for the Krein spectral shift function for an obstacle scattering system. © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
A 4.9‐dB NF 53.5‐ to 62‐GHz micromachined CMOS wideband LNA with small group‐delay‐variation
Authors: Chen Chi‐Chen , Lin Yo‐Sheng , Huang Pen‐Li , Lu Shey‐Shi 
Published: August 2010

AbstractA 53.5‐ to 62‐GHz wideband low‐noise amplifier (LNA) with excellent phase linearity property using standard 0.13 μm CMOS technology is reported.To achieve sufficient gain, the LNA is composed of six cascade common‐source stages. Current‐sharing technique is adopted to reduce power dissipation. The LNA (STD LNA) consumed 29.1 mW and achieved input return loss (S11) of −10.3 to −19.5 dB, output return loss (S22) of −13.8 to −27.8 dB, forward gain (S21) of 8.1 to 11.1 dB, and reverse isolation (S12) of −49.9 to −60.2 dB over the 53.5‐ to 62‐GHz‐band. The minimum NF (NFmin) is 5.4 dB at 62 GHz. To reduce the substrate loss, the CMOS process compatible backside inductively‐coupled‐plasma (ICP) deep trench technology is used to selectively remove the silicon underneath the LNA. After the ICP etching, the LNA (ICP LNA) achieved maximumS21(S21‐max) of 13.2 dB (at 58 GHz), 2.1 dB higher than that (11.1 dB) of the STD LNA (at 58.5 GHz). In addition, the ICP LNA achieved NFminof 4.9 dB (at 61 GHz), 0.5 dB lower than that (5.4 dB) of the STD LNA (at 62 GHz). These results demonstrate the proposed LNA architecture in conjunction with the backside ICP deep‐trench technology is very promising for high‐performance 60‐GHz‐band RFIC applications. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2427–2432, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25500
Tunable frequency equalization using variable optical tilt filter in radio‐over‐fiber links
Authors: Liu Lan , Zheng Shilie , Ji Jun , Guo Minghui , Zhang Xianmin , Jin Xiaofeng , Chi Hao , Zou Yingyin Kevin 
Published: August 2010

AbstractFrequency equalization is essential for radio‐over‐fiber (RoF) applications due to the degraded performance at higher frequencies.In this article, an easily implemented scheme for tunable frequency equalization in RoF link is proposed. A tunable and reconfigurable microwave photonic filter is used in this method, which is realized through variable optical tilt filter. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2456–2459, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25505
Forward and backward periodic microstrip antenna with a slotted ground plane
Authors: Li Yuanxin , Xue Quan , Long Yunliang 
Published: August 2010

AbstractA novel forward and backward periodic microstrip antenna is presented and tested in this article. The experimental results show that the main lobe scans electronically from 140° to 30° in y–z plane when the operating frequency increases from 3.2 to 8 GHz. The measured results show that the slotted ground plane affects the radiation characteristics of the antenna efficiently. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2608–2610, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25525
A novel printed antenna for ultrawideband RFID (UWB‐RFID) tag
Authors: AbdEl‐Raouf Hany E. , Obsiye Abdi K.H. , Islam Md. Rafiqul 
Published: August 2010

AbstractIn this article, we present the design of a modified crescent antenna for ultrawideband (UWB) radio frequency identification (RFID) tag. Different studies to optimize the design of this antenna for the UWB‐RFID system have been performed, particularly to overcome the main challenges such as minimizing the size of the antenna, improving its read range, and the effects of the metallic objects on the antenna performance. To avoid the effect of the metals that may exist below the partial ground plane, the antenna is designed using a foam layer below the partial ground plane and a full ground plane below the foam layer at the bottom of the structure. As a result, the proposed antenna has a maximum read range between 0.9 m and 4.4 m, with the ability to cover the UWB with the existing of metallic objects below the antenna. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2528–2531, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25536
Compact top‐loaded ultra‐wideband biconical antenna for indoor base‐station applications
Authors: Lu W. J. , Weng Y.F. , Cheung S.W. , Zhu H. B. 
Published: August 2010

AbstractA biconical antenna employing the top‐loaded technique is proposed for ultra‐band (UWB) operation. The antenna is composed of a small cone mounted on a top‐loaded disc and a conical ground plane, with both cones electrically connected together using four shorting pins to reduce the lower cutoff frequency. The antenna is investigated using computer simulation and measurement. Results show that the antenna has an impedance bandwidth from 0.8 GHz to over 11.2 GHz, dipole‐like omnidirectional radiation pattern, average gain of about 4.2 dBi, and average radiation efficiency of over 88%. The antenna has the advantageous features of compact size, low profile, simple structure, and ultra‐wideband characteristic and so is suitable for indoor base‐station applications of many existing and future wireless and UWB systems. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2594–2598, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25540
A balanced antenna integrated six‐port receiver using direct conversion
Authors: Kim Dong‐Zo , Lee Han‐Lim , Lee Moon‐Que , Yu Jong‐Won 
Published: August 2010

AbstractIn this article, a new balanced antenna integrated six‐port receiver architecture is proposed and experimentally verified. The proposed six‐port architecture consists of a RC‐CR filter, baluns, power combiners, and a wideband balanced antenna designed to have 100‐Ω impedance. The proposed integrated antenna architecture can reduce passive elements of the six‐port receiver and has an excellent LO‐RF isolation characteristic. The proposed six‐port receiver is simulated and verified by the experiment in 1.2 GHz for QPSK 30 Mbps. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2512–2515, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25553
Fetal cardiac tumors: a single‐center experience of 40 cases
Authors: Yinon Yoav , Chitayat David , Blaser Susan , Seed Mike , Amsalem Hagai , Yoo Shi‐Joon , Jaeggi Edgar T. 
Published: August 2010

AbstractObjectiveTo determine the natural history and outcome of fetal cardiac tumors.MethodsThis was a retrospective cohort study of all prenatally detected cases of cardiac tumors at a tertiary cardiac care center.ResultsForty fetuses were identified to have one or several cardiac tumors in association with fetal hydrops (18%), ventricular obstruction (30%) and/or arrhythmia (13%). Of 33 cases with rhabdomyoma, three patients elected to terminate the pregnancy, four offspring died at birth and 26 (79%) survived. On follow‐up, 95% of all live‐born cases with rhabdomyomas were free of cardiac symptoms but 88% had tuberous sclerosis. All three fetuses with teratoma presented with hydrops and none of them survived. In contrast, all three fetuses with cardiac fibroma are alive and have a biventricular physiology. One fetus with a large atrial hemangioendothelioma died in early infancy. Fetal or neonatal death was associated with an earlier cardiac anomaly diagnosis, earlier delivery, larger tumor size and fetal hydrops at presentation.ConclusionsThe outcome of fetal cardiac tumors was predicted by the etiology and size of the cardiac mass and the presence of hydrops. Although most cardiac rhabdomyomas have a relatively benign perinatal course, the long‐term prognosis is determined by the neurological manifestations associated with tuberous sclerosis. Copyright © 2010 John Wiley & Sons, Ltd.
PAPP‐A, free β‐hCG, and early fetal growth identify two pathways leading to preterm delivery
Authors: Kirkegaard Ida , Uldbjerg Niels , Petersen Olav Bjørn , Tørring Niels , Henriksen Tine Brink 
Published: August 2010

AbstractObjectiveTo evaluate early fetal growth and the biomarkers, pregnancy‐associated plasma protein A (PAPP‐A) and free β‐human chorionic gonadotrophin (β‐hCG), in relation to preterm delivery.MethodsA cohort study of 9450 singleton pregnant women who attended the prenatal screening program at Aarhus University Hospital between January 2005 and December 2007, was conducted. PAPP‐A and free β‐hCG were measured in the first trimester. Early fetal growth was estimated by (GA20− GA12)/Dayscalendar, where GA12 reflects the gestational age in days calculated from the crown‐rump length at a 12‐week scan, GA20 reflects the gestational age in days calculated from the biparietal diameter at a 20‐week scan, and Dayscalendar is the number of calendar days between the two scans.ResultsLow PAPP‐A and low free β‐hCG were significantly associated with preterm delivery (<37 weeks). The association was even stronger when low PAPP‐A and slow early fetal growth were combined, resulting in an adjusted odds ratio of 3.8 (95% CI, 1.6–8.7). Fast early fetal growth, but neither high PAPP‐A nor high free β‐hCG, was significantly associated with preterm delivery.ConclusionTwo different biological pathways leading to spontaneous preterm delivery are suggested: fast early fetal growth and the combination of low PAPP‐A and slow early fetal growth. Copyright © 2010 John Wiley & Sons, Ltd.
Proteome profiling of immortalization‐to‐senescence transition of human breast epithelial cells identified MAP2K3 as a senescence‐promoting protein which is downregulated in human breast cancer
Authors: Jia Min , Souchelnytskyi Nazariy , Hellman Ulf , O'Hare Michael , Jat Parmjit S. , Souchelnytskyi Serhiy 
Published: August 2010

AbstractPurpose: Immortalization is one of the first changes in cells undergoing carcinogenic transformation. Proteome profiling of the immortalization–senescence transition is expected to provide insights into the molecular mechanisms of early tumorigenesis.Experimental design: 2‐DE and MALDI‐MS were used to identify proteins in primary human breast epithelial cells, relevant to the immortalization–senescence transition. Cell and molecular biology and immunohistochemistry were used to validate involvement of mitogen‐activated protein kinase kinase 3 (MAP2K3) in the immortalization–senescence transition.Results: We identified 71 proteins whose expression changed upon induction of senescence. The identified proteins include regulators of cell growth, death, cell assembly and organization. Analysis of the network formed by the identified proteins suggested that the immortalization‐to‐senescence transition could affect regulators of the cell cycle, protein synthesis, transport, post‐translational modifications, DNA recombination and repair, and lipid and amino acid metabolism. We observed that MAP2K3 was downregulated in immortal human breast epithelial cells and that upregulation of MAP2K3 expression promoted cell senescence. Decreased expression of MAP2K3 was observed in human breast infiltrating ductal carcinomas, as compared to non‐cancerous human breast tissues.Conclusion and clinical relevance: We described a proteome profile of the immortalization‐to‐senescence transition for human breast epithelial cells, and identified MAP2K3 as a protein that promotes senescence in these cells.
Impact of the storage temperature on human plasma proteomic analysis: Implications for the use of human plasma collections in research
Authors: Insenser María , Martínez‐García M. Ángeles , Nieto Rafael Montes , San‐Millán José L. , Escobar‐Morreale Héctor F. 
Published: August 2010

AbstractPurpose: To analyze the impact of storage temperature on the 2D‐DIGE profile of human plasma.Experimental design: 2D‐DIGE and MS were used to identify the differences in the proteomic profiles of aliquots of eight human plasma samples stored at either −30 or −80°C for 18 months.Results: After the depletion of albumin and IgG, 2D‐DIGE identified four spots significantly and reproducibly increased, and five spots that were decreased, in samples stored at −30°C compared with those stored at −80°C. These nine spots were manually excised, digested in‐gel and analyzed by MALDI‐TOF/TOF. MASCOT database search using the PMF spectra allowed the identification of the proteins present in eight of the nine spots. All the spots corresponded to the complement C3 precursor protein.Conclusions and clinical relevance: Our present results indicate that plasma collections stored at −30°C, and not only those stored at −80°C, may be used for 2D‐DIGE analyses of albumin‐ and IgG‐depleted human plasma without loosing the essential information about highly abundant proteins. This finding expands the applicability of 2D‐DIGE to the study of human disease by permitting the analysis of human plasma samples stored at temperatures between −30 and −80°C.
Prominin‐1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate
Authors: Missol‐Kolka Ewa , Karbanová Jana , Janich Peggy , Haase Michael , Fargeas Christine A. , Huttner Wieland B. , Corbeil Denis 
Published: August 2010

AbstractBACKGROUNDRodent and human prominin‐1 are expressed in numerous adult epithelia and somatic stem cells. A report has shown that human PROMININ‐1 carrying the AC133 epitope can be used to identify rare prostate basal stem cells (Richardson et al., J Cell Sci 2004; 117:3539–3545). Here we re‐investigated its general expression in male reproductive tract including mouse and human prostate and in prostate cancer samples using various anti‐prominin‐1 antibodies.METHODSThe expression was monitored by immunohistochemistry and blotting. Murine tissues were stained with 13A4 monoclonal antibody (mAb) whereas human samples were examined either with the AC133 mAb recognizing the AC133 glycosylation‐dependent epitope or 80B258 mAb directed against the PROMININ‐1 polypeptide.RESULTSMouse prominin‐1 was detected at the apical domain of epithelial cells of ductus deferens, seminal vesicles, ampullary glands, and all prostatic lobes. In human prostate, immunoreactivity for 80B258, but not AC133 was revealed at the apical side of some epithelial (luminal) cells, in addition to the minute population of AC133/80B258‐positive cells found in basal compartment. Examination of prostate adenocarcinoma revealed the absence of 80B258 immunoreactivity in the tumor regions. However, it was found to be up‐regulated in luminal cells in the vicinity of the cancer areas.CONCLUSIONSMouse prominin‐1 is widely expressed in prostate whereas in human only some luminal cells express it, demonstrating nevertheless that its expression is not solely associated with basal stem cells. In pathological samples, our pilot evaluation shows that PROMININ‐1 is down‐regulated in the cancer tissues and up‐regulated in inflammatory regions. Prostate 71:254–267, 2011. © 2010 Wiley‐Liss, Inc.
Statins reduce the androgen sensitivity and cell proliferation by decreasing the androgen receptor protein in prostate cancer cells
Authors: Yokomizo Akira , Shiota Masaki , Kashiwagi Eiji , Kuroiwa Kentaro , Tatsugami Katsunori , Inokuchi Junichi , Takeuchi Ario , Naito Seiji 
Published: August 2010

AbstractBACKGROUNDStatins (3‐hydroxy‐3‐methyl‐glutaryl‐coenzyme A reductase inhibitors) are cholesterol‐lowering drugs that are widely used to prevent and treat atherosclerotic cardiovascular disease. Recent epidemiological studies suggest that statins reduce serum prostate‐specific antigen (PSA) levels and decrease the risk of prostate cancer. In the present study, we determined the molecular mechanisms related to the regulation of PSA, androgen receptor (AR) and cell proliferation in prostate cancer cell lines by statins.METHODSWestern blotting, quantitative real‐time polymerase chain reaction, cytotoxicity analysis and a cell proliferation assay were used to resolve the regulatory role of statins (mevastatin and simvastatin) in three prostate cancer cell lines, RWPE‐1, 22Rv1, and LNCaP.RESULTSWestern blotting revealed that both mevastatin and simvastatin downregulated AR and PSA protein. However, these statins did not downregulate AR mRNA expression, while they decreased PSA mRNA. The protease inhibitor MG132 inhibited the downregulation of AR protein which suggested that statins decreased AR protein levels by increasing AR proteolysis. Furthermore, statins reduced cell proliferation in AR positive cells but not in AR negative cells, suggesting that statins regulate cell proliferation via AR expression. In addition, cell proliferation assay at various concentrations of dihydrotestosterone (DHT) showed that statins decreased androgen sensitivity in LNCaP cells.CONCLUSIONSStatins decreased AR protein by proteolysis but not mRNA transcription. The drop in AR levels resulted in a reduction in androgen sensitivity and a decrease in cell proliferation in AR positive prostate cancer cells. Prostate 71:298–304, 2011. © 2010 Wiley‐Liss, Inc.
The fluorescence of variously terminated nanodiamond particles: Quantum chemical calculations
Authors: Kratochvílová I. , Kovalenko A. , Taylor A. , Fendrych F. , Řezáčová V. , Vlček J. , Záliš S. , Šebera J. , Cígler P. , Ledvina M. , Nesládek M. 
Published: August 2010

AbstractNanodiamond is a novel and promising material for in vitro and in vivo imaging in living cells. In this work, we studied (using quantum chemical calculation methods) how the various surface terminations affect the conditions for the fluorescence of nitrogen‐vacancy (NV) centers in nanodiamond particles. We worked with clusters containing between 35 and 86 atoms of carbon containing NV centers with different charge states of their vacancies (NV− and NV0) and with different terminations: OH, H, NH2, carbonyl, carboxyl, and hydroxyl groups. The systems under study were modeled by DFT‐based calculations using the Gaussian 09 and Turbomole‐5.10 program packages.
Determination of carrier diffusion coefficient and lifetime in single crystalline CVD diamonds by light‐induced transient grating technique
Authors: Malinauskas T. , Jarašiūnas K. , Ivakin E. , Tranchant N. , Nesladek M. 
Published: August 2010

AbstractWe report on a contactless, all‐optical study of carrier diffusion and recombination kinetics in single‐crystalline diamond layers using the light‐induced transient grating (LITG) technique. Decay times of transient diffraction grating yielded carrier lifetime of τR ≈ 3 ns and bipolar diffusion coefficient Da = 12 cm2/s at 300 K. The latter value of Da was found to be 4–5 times lower than the ambipolar diffusivity based on electron and hole mobilities, measured by photo‐electrical time‐of‐flight (ToF) technique. This discrepancy was attributed to the bandgap renormalization at high excess carrier densities and its impact on carrier diffusion. The significant decrease of low temperature diffusivity pointed out to a contribution of many‐body effects which are tentatively attributed to the formation of electron–hole liquid (EHL) at T < 150 K.
Density and physical current density functional theory
Authors: Pan Xiao‐Yin , Sahni Viraht 
Published: August 2010

AbstractFor a system of N electrons in an external scalar potential v(r) and external vector potential A(r), we prove that the wave function ψ is a functional of the gauge invariant ground state density ρ(r) and ground state physical current density j(r), and a gauge function α(R) (with R = r1,…,rN):ψ=ψ [ρ,j,α]. It is the presence of the gauge function α(R) that ensures the wave function functional is gauge variant. We prove this via a unitary transformation and by a proof of the bijectivity between the potentials {v(r),A(r)} and the ground state properties {ρ(r),j(r)}. Thus, the natural basic variables for the system are the gauge invariant ρ(r) and j(r). Because each choice of gauge function corresponds to the same physical system, the choice of α(R) = 0 is equally valid. As such, we construct a {ρ(r),j(r)} functional theory with the corresponding Euler equations for the density ρ(r) and physical current density j(r) , together with the constraints of charge conservation and continuity of the current. With the assumption of existence of a system of noninteracting fermions with the same ρ(r) and j(r) as that of the electrons, we provide the equations describing this model system, the definitions being within the framework of Kohn–Sham theory in terms of energy functionals of {ρ(r),j(r)} and their functional derivatives. A special case of the {ρ(r),j(r)} functional theory is the magnetic‐field density‐functional theory of Grayce and Harris. We discuss and contrast our work with the paramagnetic current‐ and density‐functional theory of Vignale and Rasolt in which the variables are the gauge invariant ground state density ρ(r), and vorticity ν(r) = ∇× (jp(r)/ρ(r)) , where jp(r) is the paramagnetic current density. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Multiphoton microscopic imaging of normal human rectum tissue
Authors: Liu Nenrong , Chen Gang , Chen Jianxin , Yan Jun , Zhuo Shuangmu , Zheng Liqin , Jiang Xingshan 
Published: August 2010

AbstractIn this paper, multiphoton microscopy (MPM), based on two‐photon excited fluorescence and second harmonic generation signals, was used to image microstructures of human rectal mucosa and submucosa. The morphology and distribution of the main components in mucosa layer, goblet cells, intestinal glands, and a little collagen fibers have been clearly monitored, and the content and distribution of collagen, elastic fibers, and blood vessels in submucosa layer have also been distinctly obtained. The variation of these components is very relevant to the pathology in gastrointestinal system, especially early rectal cancer. Our results indicate that the MPM technique has the potential application in vivo in the clinical diagnosis and monitoring of early rectal cancer. SCANNING 32: 347–350, 2010. © 2010 Wiley Periodicals, Inc.