bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of verjuice (Vitis vinifera L.) on physicochemical and textural properties of beef M. biceps femoris
Authors: Sabzi Fereshteh , Varidi Mohammad Javad , Varidi Mehdi , Asnaashari Maryam 
Published: May 2024

AbstractThe objective of this study was to investigate the effect of verjuice on beef M. biceps femoris (BF). BF blocks were marinated with 30%, 70%, and 100% verjuice solutions containing 2% NaCl, for different marination times (12, 24, 48, and 72 h). Verjuice marination reduced the pH values of BF samples from 6.77 in control sample to 3.66 in 100% of verjuice for 72 h. The decreased values of water holding capacity (from 54.06% to 47.46%) with increasing verjuice concentration (from 30% to 100% for 72 h) confirmed the drop of proteins isoelectric point of the muscle due to salt presence preventing fibers swelling. Less cookout was observed with increasing acid concentration. Marination time had no significant effect on L* and a* coordinates of uncooked samples while acidification made the samples lighter and less red. Enzymatic proteolysis of myosin and troponin‐T concomitant with increase in myofibrillar fragmentation index contributed to the decrease of shear force in a way dependent on verjuice concentration and marination time. Sensory panelists gave the highest score to cooked samples marinated with 70% verjuice solution.
The internal mammary artery perforator flap in pharyngoesophageal, cervical tracheal, and cutaneous neck reconstruction
Authors: Sharbel Daniel , Lin Chen , Topf Michael C. , Mannion Kyle 
Published: May 2024

AbstractThe internal mammary artery perforator (IMAP) flap is an evolution of the deltopectoral flap that is harvested based upon a single perforator from the internal mammary artery. Its favorable characteristics include pliability as a fasciocutaneous flap, ease of harvest, and minimal donor site morbidity. In this paper, we report our harvest technique and the versatility of the IMAP flap for pharyngoesophageal, cervical tracheal, and cutaneous neck defects. We seek to highlight the IMAP as a useful regional reconstructive option in both the primary and salvage reconstructive setting. As such, this flap is an important option in the head and neck reconstructive surgeon's armamentarium.
Sustainable Twist – Towards Highly Atom Efficient Grignard Processes
Authors: Kohler Philipp , Kirchner Eva , Păunescu Emilia , Mayerhöffer Ulrich 
Published: May 2024

AbstractCopper salts, which are widely applied in chemical processes, are highly toxic for aquatic life with devastating and long‐lasting effects. The most sustainable measure to prevent negative impact on surface water bodies is the elimination of copper from chemical processes. In Grignard reactions, acyl chlorides are widely used in combination with copper(I) chloride to introduce acyl substituents to aromatic compounds. We demonstrate that carboxylic acid anhydrides are a competent and highly selective alternative to acyl chlorides when used in the absence of copper(I) catalysts. An integrated value stream cycle allows for recycling of the carboxylate salt byproducts by reaction with ketene, thereby reducing the waste output to almost zero. This proposed process can therefore contribute to minimizing both chemical waste and heavy metal input into water bodies.
Analytical solution to boundary layer flow and convective heat transfer for low Prandtl number fluids under the magnetic field effect over a flat plate
Authors: Agrawal Ajay Kumar , Gupta Yogesh 
Published: May 2024

AbstractThe present study aims to quantify the flow field, flow velocity, and heat transfer features over a horizontal flat plate under the influence of an applied magnetic field, with a particular emphasis on low Prandtl number fluids. Nonlinear partial differential expressions can be incorporated into the ordinary differential framework with the use of appropriate transformations. This research utilizes the variational iteration method (VIM) to approximate solutions for the system of nonlinear differential equations that define the problem. The objective is to demonstrate superior flexibility and broader application of the VIM in addressing heat transfer issues, compared to alternative approaches. The results obtained from the VIM are compared with numerical solutions, revealing a significant level of accuracy in the approximation. The numerical findings strongly suggest that the VIM is effective in providing precise numerical solutions for nonlinear differential equations. The analysis includes an examination of the flow field, velocity, and temperature distribution across various parameters. The study found that improving temperature patterns, velocity distribution, and flow dynamics were all positively impacted by increasing the Prandtl numbers. As a result, this leads to the thickness of the boundary layer to decrease and improves heat transfer at the moving surface. Thus, the convection process becomes more efficient. When the strength of the magnetic field is increased, the velocity of the fluid decreases. This observation aligns with expectations since the magnetic field hampers the natural flow of convection. Notably, the convection process can be precisely controlled by carefully applying magnetic force.
Heterogeneous treatment effect of dose‐dense paclitaxel plus carboplatin therapy for advanced ovarian cancer
Authors: Taguchi Ayumi , Kato Kosuke , Furusawa Akiko , Hara Konan , Sone Kenbun , Yamada Kyosuke , Kajiyama Hiroaki , Shimada Muneaki , Okamoto Aikou 
Published: May 2024

AbstractA Japanese clinical trial (JGOG3016) showed that dose‐dense weekly paclitaxel in combination with carboplatin extensively prolonged overall survival (OS) in patients with advanced ovarian cancer. However, in other clinical trials, dose‐dense paclitaxel regimens were not superior to triweekly paclitaxel regimens. In this study, causal tree analysis was applied to explore subpopulations with different treatment effects of dose‐dense paclitaxel in a data‐driven approach. The 587 participants with stage II–IV ovarian cancer in the JGOG3016 trial were used for model development. The primary endpoint was treatment effect in terms of 3‐year OS in patients receiving dose‐dense vs. conventional paclitaxel therapies. In patients <50 years, the 3‐year OS was similar in both groups; however, it was higher in the dose‐dense group in patients ≥50 years. Dose‐dense paclitaxel showed strong positive treatment effects in patients ≥50 years with stage II/III disease, BMI <23 kg/m2, non‐CC/MC, and residual tumor ≥1 cm. In contrast, although there was no significant difference in OS; the 3‐year OS rate was 23% lower in dose‐dense paclitaxel than conventional paclitaxel in patients ≥60 years with stage IV cancer. Patients in this group had a particularly lower performance status than other groups. Our causal tree analysis suggested that poor prognosis groups represented by residual tumor tissue ≥1 cm benefit from dose‐dense paclitaxel, whereas elderly patients with advanced disease and low‐performance status are negatively impacted by dose‐dense paclitaxel. These subpopulations will be of interest to future validation studies. Personalized treatments based on clinical features are expected to improve advanced ovarian cancer prognosis.
Exploring factors influencing the entrepreneurial intentions of the youth community towards green ICT to encourage environmental sustainability: Evidence from an emerging economy
Authors: Bhardwaj Shivam , Agarwal Sucheta , Tripathi Vikas 
Published: May 2024

AbstractInformation and communication technologies (ICTs) have a complex relationship with the environment, with certain positive as well as negative effects. Through a comprehensive examination of the entrepreneurial landscape in the domain of green ICT in Uttar Pradesh, India, the research aims to investigate the factors influencing the entrepreneurial intentions of the youth community towards green ICT to encourage environmental sustainability. The research shed light on the involved interplay of individual characteristics, social and environmental contexts, and educational and institutional support systems. By employing a comprehensive qualitative study‐interview approach combined with exploratory factor analysis (EFA) various factors such as technological innovation, supportive regulatory frameworks (government policies), entrepreneurial resilience, family and social network support, environmental awareness and concern, availability of resources, market demand, and support of academic institutions are identified as the prominent factors which underscore the multifaceted nature of entrepreneurial intentions among the youth community. The findings contribute valuable insights for policymakers, educators, and entrepreneurs alike, emphasizing the need for targeted interventions and policies to nurture a vibrant ecosystem of green ICT entrepreneurship, thereby driving sustainable development and environmental conservation.
Bank tail risk in China
Authors: Yang Huan , Cai Jun , Huang Lin 
Published: May 2024

AbstractIn this study, we investigate the tail dependency between bank stocks in China and 35 common risk factors. We measure univariate and multivariate conditional tail risk probabilities. The evidence indicates that tail events from risk factors in the banking, security trading, real estate, and energy industries have the largest effects on the realization of extreme returns from Chinese bank stocks. The univariate conditional tail risk is considerably higher than the unconditional tail risk. The impact of multiple tail events from several risk factors occurring simultaneously is much stronger than tail events from one single risk factor. In general, there is a stronger cross‐market tail linkage between emerging market risk factors and bank stocks in China when compared with developed market risk factors. However, the cross‐market tail linkage between developed market risk factors and bank stocks in China rose sharply during the 2008 financial crisis.
BDNF, proBDNF and proBDNF/BDNF ratio with electroencephalographic abnormalities in children with attention deficit hyperactivity disorder: Possible relations to cognition and severity
Authors: El‐Saied Mostafa M. , Afify Omneya , Abdelraouf Ehab R. , Oraby Azza , Hashish Adel F. , Zeidan Hala M. 
Published: May 2024

AbstractAttention deficit hyperactivity disorder (ADHD) with and without subclinical epileptogenic discharges (SED) have been suggested to negatively affect cognitive abilities of children with ADHD. The role of brain‐derived neurotrophic factor (BDNF) and its precursor proBDNF in ADHD is in need of being investigated. The aims were to evaluate the levels of serum BDNF, proBDNF and the proBDNF/BDNF ratio in addition to the potential impacts of SED on the children's cognitive abilities and the severity of ADHD. The included participants with ADHD were 30 children with normal electroencephalogram (EEG) (G1) and 30 children with SED (G2), together with 30 healthy children (G3). The cognitive abilities and severity of the disorder were evaluated. The biochemical measures were determined by ELISA. The presence of coexisting SED and nocturnal enuresis has led to a deleterious effect on cognitive processes but not on the severity. The focal epileptogenic discharge was the most common among children in G2. The levels of BDNF in Groups 1 and 2 were less than those in G3. The higher proBDNF/BDNF ratio could be related to the low BDNF levels rather than high proBDNF levels. The findings of this study highlight the importance of investigating the presence of SED and nocturnal enuresis in children with ADHD. Targeting strengthening of cognitive abilities in children with coexisting ADHD and SED is advised. The role of proBDNF in the pathophysiology of ADHD needs further investigation.
A practical guide to the implementation of artificial intelligence in orthopaedic research—Part 2: A technical introduction
Authors: Zsidai Bálint , Kaarre Janina , Narup Eric , Hamrin Senorski Eric , Pareek Ayoosh , Grassi Alberto , Ley Christophe , Longo Umile Giuseppe , Herbst Elmar , Hirschmann Michael T. , Kopf Sebastian , Seil Romain , Tischer Thomas , Samuelsson Kristian , Feldt Robert ,   ESSKA Artificial Intelligence Working Group
Published: May 2024

AbstractRecent advances in artificial intelligence (AI) present a broad range of possibilities in medical research. However, orthopaedic researchers aiming to participate in research projects implementing AI‐based techniques require a sound understanding of the technical fundamentals of this rapidly developing field. Initial sections of this technical primer provide an overview of the general and the more detailed taxonomy of AI methods. Researchers are presented with the technical basics of the most frequently performed machine learning (ML) tasks, such as classification, regression, clustering and dimensionality reduction. Additionally, the spectrum of supervision in ML including the domains of supervised, unsupervised, semisupervised and self‐supervised learning will be explored. Recent advances in neural networks (NNs) and deep learning (DL) architectures have rendered them essential tools for the analysis of complex medical data, which warrants a rudimentary technical introduction to orthopaedic researchers. Furthermore, the capability of natural language processing (NLP) to interpret patterns in human language is discussed and may offer several potential applications in medical text classification, patient sentiment analysis and clinical decision support. The technical discussion concludes with the transformative potential of generative AI and large language models (LLMs) on AI research. Consequently, this second article of the series aims to equip orthopaedic researchers with the fundamental technical knowledge required to engage in interdisciplinary collaboration in AI‐driven orthopaedic research.Level of EvidenceLevel IV.
Thermotolerance in S. cerevisiae as a model to study extracellular vesicle biology
Authors: Logan Curtis John , Staton Claire C. , Oliver Joshua Thomas , Bouffard Jeff , Kazmirchuk Thomas David Daniel , Magi Melissa , Brett Christopher Leonard 
Published: May 2024

AbstractThe budding yeast Saccharomyces cerevisiae is a proven model organism for elucidating conserved eukaryotic biology, but to date its extracellular vesicle (EV) biology is understudied. Here, we show yeast transmit information through the extracellular medium that increases survival when confronted with heat stress and demonstrate the EV‐enriched samples mediate this thermotolerance transfer. These samples contain vesicle‐like particles that are exosome‐sized and disrupting exosome biogenesis by targeting endosomal sorting complexes required for transport (ESCRT) machinery inhibits thermotolerance transfer. We find that Bro1, the yeast ortholog of the human exosome biomarker ALIX, is present in EV samples, and use Bro1 tagged with green fluorescent protein (GFP) to track EV release and uptake by endocytosis. Proteomics analysis reveals that heat shock protein 70 (HSP70) family proteins are enriched in EV samples that provide thermotolerance. We confirm the presence of the HSP70 ortholog stress‐seventy subunit A2 (Ssa2) in EV samples and find that mutant yeast cells lacking SSA2 produce EVs but they fail to transfer thermotolerance. We conclude that Ssa2 within exosomes shared between yeast cells contributes to thermotolerance. Through this work, we advance Saccharomyces cerevisiae as an emerging model organism for elucidating molecular details of eukaryotic EV biology and establish a role for exosomes in heat stress and proteostasis that seems to be evolutionarily conserved.
Liebig review: The role of mineral nutrients in the development of Pseudomonas syringae diseases—Lessons learned and implications for disease control in woody plants
Authors: Soethe Nathalie , Hulin Michelle T. , Balasus Antje , Preston Gail , Geilfus Christoph‐Martin 
Published: May 2024

AbstractBackgroundThe plant pathogen Pseudomonas syringae (Ps) causes diseases in a broad range of hosts including important cash crops from several climate zones. In particular for woody crops, effective and environmentally friendly disease control strategies are not available. Although there is increasing evidence of a link between plant nutritional status and disease susceptibility, optimization of plant nutrition is often neglected in efforts to control Ps diseases. This review brings current knowledge on this topic together with the aim of facilitating the development of treatment recommendations in specific contexts.Literature reviewThe article consists of three parts. First, we compiled data on the impact of mineral nutrients on Ps disease severity in woody and herbaceous species. Next, we discuss how nutrients may be related to plant defense and/or Ps virulence. Last, we consider these findings in the context of woody hosts and give suggestions for future research.ConclusionsWe encourage a research focus on typical nutrient imbalances (deficiencies and surpluses) in specific orchard regions; testing the role of foliar fertilizers in spring (the period of highest infection risk); analyses of the interaction between nutrient supply and the microbiome in the phyllosphere; investigating the interaction between nutrient supply and other control measures, and the impact of nutrient supply on Ps diseases in the presence of other stress factors.
Near‐field communication integration into in‐cell touch thin‐film‐transistor liquid‐crystal display
Authors: Feng Boshi , Chen Xiuyun , Wang Guangquan , Liu Yujie , Long Feng , Cai Site , Shao Xibin 
Published: May 2024

AbstractIn this paper, we demonstrated the front NFC card swipe and touch display in Touch and Display Driver Integration (TDDI) liquid crystal display (LCD) through the technologies shown later. A new NFC sampling and noise reduction algorithm was used to reduce the generation of the ghost position and touch failure. The touch/NFC part‐time driving was applied to optimize the noise interference when NFC works. Meanwhile, we integrated the NFC antenna in the TDDI LCD and added a new display signal filter circuit and VCOM driver signal. In the NFC in‐cell demo, front NFC swiping distance of 60 mm is achieved.
High‐luminance and Highly Reliable Tandem OLED Display Including New Intermediate Connector Designed for Photolithography Applications
Authors: Fukuzaki Shinya , Sasaki Toshiki , Nowatari Hiromi , Oe Yuko , Yamada Yui , Ohsawa Nobuharu , Yamazaki Shunpei 
Published: May 2024

AbstractWe achieved a high‐luminance and highly reliable tandem organic light‐emitting diode (OLED) designed for photolithography applications by developing a new intermediate connector with high resistance to water and atmospheric elements. We succeeded in fabricating a red, green, and blue (RGB) side‐by‐side (SBS) tandem OLED display without a fine metal mask using our SBS pixel‐patterning method involving organic layer etching via photolithography.
Research on reconfigurable waveguide devices based on liquid crystal on silicon
Authors: Sun Ren , Shi Yujian , Zhao Xianyu , Long Zhen , Li Qing 
Published: May 2024

AbstractDue to the limitation of materials, PIC cannot achieve large magnitude phase modulation in a small size, and lacks the reconfigurable ability. Because of its birefringence characteristic, liquid crystal can be used in the liquid crystal on silicon (LCoS) device to achieve a large amount of phase modulation in a small size and has the capacity of reconstruction. Based on the experimental results of LCoS devices and basic liquid crystal waveguide devices, the liquid crystal waveguide device is prepared. While retaining the LCoS spatial optical phase modulation capability, the liquid crystal waveguide and phase modulation capability are realized. The beam splitter, optical switch, and Mach–Zehnder interferometer structure are constructed, which verifies the feasibility of the liquid crystal waveguide phase modulator.
Immunotherapy associated Sweet syndrome in a patient with metastatic melanoma: A case report
Authors: Barry Rory , Murray Gregg , McGrath Sally , Kilgallen Clive , Eustace Karen 
Published: May 2024

AbstractImmunotherapy agents are now widely used in the treatment of metastatic melanoma. Immune‐related adverse events (irAEs) may occur, including cutaneous pathologies in 50% of patients. We report a case of Sweet syndrome (SS) in a patient who was prescribed ipilimumab and nivolumab for metastatic melanoma.
Medial‐pivot total knee arthroplasty enhances tibiofemoral axial rotation stability in weight‐bearing mid‐range flexion compared to posterior‐stabilised system
Authors: Yu Wanxin , Zou Diyang , Tan Jiaqi , Zheng Nan , Ma Xin , Cheng Rongshan , Chen Yunsu , Tsai Tsung‐Yuan 
Published: May 2024

AbstractPurposeTotal knee arthroplasty (TKA) stands as a primary intervention for severe knee ailments, yet concerns remain regarding postoperative patient satisfaction and flexion instability. This study aims to evaluate the in‐vivo kinematics of medial‐pivot (MP) and posterior‐stabilised (PS) designs during step‐up activity, in comparison to the kinematics of the nonoperated contralateral knee.MethodsSixteen patients with PS‐TKA and 14 with MP‐TKA were retrospectively examined. Clinical outcomes were assessed using patient‐completed questionnaires. Motion during step‐up was captured using a dual fluoroscopic system. Statistical analysis was applied to evaluate the in‐vivo tibiofemoral six‐degree‐of‐freedom kinematics and articular contact positions between the two groups.ResultsDespite being older, patients in the MP group reported higher postoperative subjective scores for weight‐bearing functional activities. The axial rotation centres of MP‐TKA located on the medial tibial plateau exhibited less variance compared to PS‐TKA and contralateral knees. Compared to the contralateral knee (contralateral to medial‐pivot [C‐MP] or contralateral to posterior‐stabilised [C‐PS]), the MP group exhibited limited range of motion in terms of anteroposterior translation (MP: 3.6 ± 1.3 mm vs. C‐MP: 7.4 ± 2.5 mm, p < 0.01) and axial rotation (MP: 6.6 ± 1.9° vs. C‐MP: 10.3 ± 4.9°, p = 0.02), as well as in the PS group for anteroposterior translation (PS: 3.9 ± 1.7 mm vs. C‐PS: 7.2 ± 3.7 mm, p < 0.01).ConclusionThe MP group with better postoperative ratings demonstrated a more stable MP axial rotation pattern during step‐up activity compared to the PS group, underscoring the pivotal role of prosthetic design in optimising postoperative rehabilitation and functional recovery.Level of EvidenceLevel III.