bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of patients with different stages of acute-on-chronic liver failure treated with artificial liver support system
Authors: Ma Yuanji , Xu Yan , Du Lingyao , Bai Lang , Tang Hong 
Published: May 2024

BackgroundElevated international normalized ratio of prothrombin time (PT-INR) is one of the key characteristics of acute-on-chronic liver failure (ACLF). Whether the staging of PT-INR has the ability to screen out subgroups of ACLF patients who would be more eligible for artificial liver support system (ALSS) treatment has not been studied in detail.MethodsA previous study enrolled patients receiving ALSS treatment with regional citrate anticoagulation from January 2018 to December 2019. Patients with different PT-INR intervals were retrospectively enrolled: 1.3 ≤ PT-INR &lt; 1.5 (Pre-stage), 1.5 ≤ PT-INR &lt; 2.0 (Early-stage), 2.0 ≤ PT-INR &lt; 2.5 (Mid-stage), and PT-INR ≥ 2.5 (End-stage). The Cox proportional hazards models were used to estimate the association between stages of ACLF or sessions of ALSS treatment and 90 day mortality.ResultsA total of 301 ACLF patients were enrolled. The 90 day mortality risk of Early-stage ACLF patients (adjusted hazard ratio (aHR) (95% confidence interval (CI)), 3.20 (1.15–8.89), p = 0.026), Mid-stage ACLF patients (3.68 (1.34–10.12), p = 0.011), and End-stage ACLF patients (12.74 (4.52–35.91), p &lt; 0.001) were higher than that of Pre-stage ACLF patients, respectively. The 90 day mortality risk of Mid-stage ACLF patients was similar to that of Early-stage ACLF patients (1.15 (0.69–1.94), p = 0.591). The sessions of ALSS treatment was an independent protective factor (aHR (95% CI), 0.81 (0.73–0.90), p &lt; 0.001). The 90 day mortality risk in ACLF patients received 3–5 sessions of ALSS treatment was lower than that of patients received 1–2 sessions (aHR (95% CI), 0.34 (0.20–0.60), p &lt; 0.001), whereas the risk in patients received ≥6 sessions of ALSS treatment was similar to that of patients received 3–5 sessions (0.69 (0.43–1.11), p = 0.128).ConclusionACLF patients in Pre-, Early-, and Mid-stages might be more eligible for ALSS treatment. Application of 3–5 sessions of ALSS treatment might be reasonable.
Disease spectrum and prognostic factors in patients treated for tuberculous meningitis in Shaanxi province, China
Authors: Wang Ting , Li Meng-yan , Cai Xin-shan , Cheng Qiu-sheng , Li Ze , Liu Ting-ting , Zhou Lin-fu , Wang Hong-hao , Feng Guo-dong , Marais Ben J. , Zhao Gang 
Published: May 2024

BackgroundTuberculous meningitis (TBM) is the most severe form of tuberculosis (TB) and can be difficult to diagnose and treat. We aimed to describe the clinical presentation, diagnosis, disease spectrum, outcome, and prognostic factors of patients treated for TBM in China.MethodsA multicenter retrospective study was conducted from 2009 to 2019 enrolling all presumptive TBM patients referred to Xijing tertiary Hospital from 27 referral centers in and around Shaanxi province, China. Patients with clinical features suggestive of TBM (abnormal CSF parameters) were included in the study if they had adequate baseline information to be classified as “confirmed,” “probable,” or “possible” TBM according to international consensus TBM criteria and remained in follow-up. Patients with a confirmed alternative diagnosis or severe immune compromise were excluded. Clinical presentation, central nervous system imaging, cerebrospinal fluid (CSF) results, TBM score, and outcome—assessed using the modified Barthel disability index—were recorded and compared.FindingsA total of 341 presumptive TBM patients met selection criteria; 63 confirmed TBM (25 culture positive, 42 Xpert-MTB/RIF positive), 66 probable TBM, 163 possible TBM, and 49 “not TBM.” Death was associated with BMRC grade III (OR = 5.172; 95%CI: 2.298–11.641), TBM score ≥ 15 (OR = 3.843; 95%CI: 1.372–10.761), age &gt; 60 years (OR = 3.566; 95%CI: 1.022–12.442), and CSF neutrophil ratio ≥ 25% (OR = 2.298; 95%CI: 1.027–5.139). Among those with confirmed TBM, nearly one-third (17/63, 27.0%) had a TBM score &lt; 12; these patients exhibited less classic meningitis symptoms and signs and had better outcomes compared with those with a TBM score ≥ 12. In this group, signs of disseminated/miliary TB (OR = 12.427; 95%CI: 1.138–135.758) and a higher TBM score (≥15, OR = 8.437; 95%CI: 1.328–53.585) were most strongly associated with death.ConclusionTBM patients who are older (&gt;60 years) have higher TBM scores or CSF neutrophil ratios, have signs of disseminated/miliary TB, and are at greatest risk of death. In general, more effort needs to be done to improve early diagnosis and treatment outcome in TBM patients.
The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy
Authors: Kumthekar Priya U. , Blouw Barbara , Corkos Perry , Nagpal Seema , Tripathy Arushi , Piccioni David , Youssef Michael 
Published: May 2024

IntroductionCNSide is a platform that detects and characterizes tumor cells in the cerebrospinal fluid (CSF) of patients with leptomeningeal disease (LMD). The platform was validated per College of American Pathologists (CAP) and Clinical Laboratories Improvement Amendment (CLIA) guidelines and run as a commercial Laboratory Developed Test (LDT) at Biocept in San Diego, CA. The platform allows CSF tumor cell (CSF-TC) enumeration and biomarker characterization by fluorescent in situ hybridization (FISH). MethodsWe performed a multicenter retrospective chart review of HER2 FISH CNSide test results that were commercially ordered on 26 patients by physicians for LMD breast cancer patients between April 2020 and October 2022.ResultsWe show that HER2 is amplified on CSF tumor cells in 62% (16/26) of LMD breast cancer patients. 10/26 (38%) patients had discordant HER2-positivity between the primary tumor tissue and CSF-TC; of these, 35% (9/26) of the patients displayed HER2 amplification on the CSF-TCs, however were categorized as HER2 negative on the primary tumor. Of the 27% (7/26) patients with a HER2 positive primary tumor, one patient showed a HER2 negative LMD tumor. Two patients, 8% (2/26) had a HER2 equivocal primary tumor; of these, one demonstrated a HER2 negative, and one a HER2 positive LMD tumor. Serial analysis (at least 4 longitudinal tests) of HER2 status of the CSF-TC throughout therapy was available for 14 patients and demonstrated that HER2 status of the LMD changed in 29% (4/14) during their treatment course and impacted care decisions. ConclusionsOur data suggests that CSF-TC HER2 FISH analysis in LMD breast cancer patients may be discordant to the primary tumor sample and the discovery of HER2 positivity in the CSF may open doors to anti-HER2 targeted therapy options for LMD patients.
Percutaneous triamcinolone injection for upper eyelid retraction in thyroid eye disease
Authors: Parsons Shaun R. , Wilson-Pogmore Ario , Sullivan Timothy J. 
Published: May 2024

PurposeTo evaluate percutaneous triamcinolone (TA) injection efficacy in treating upper eyelid retraction (UER) for Australian thyroid eye disease (TED) patients.MethodsWe conducted a retrospective analysis across 8 years and multiple diverse Australian centres identified UER patients who received TA injections. A single operator administered 40mg/1ml TA through upper eyelid skin. Assessments at 4-6 weeks and subsequent eyelid measurements gauged treatment response and complications.Results24 patients and 25 eyelids were included in the study. 91.6% were female, mean age 40.8 ± 10.3 years with mean follow-up of 17.5 months (± 18.5). Pre-treatment MRD1 was 6.2mm ± 1.4, and we observed a mean improvement of 2.2mm from pre-treatment to post-treatment (p&lt;0.001). The mean UER measurement before treatment (defined as MRD1 - 4.0mm) was 3.0mm ± 1.3 (range, 0-6mm). After treatment, the mean UER measurement was -0.1mm. Quality of life (QOL) assessment improved significantly, from pre-treatment score of 4.13 ± 2.4 to post-treatment 8.0 ±1.7 (p&lt;0.001).ConclusionsPercutaneous injection of TA is an effective and safe treatment option for UER in patients with TED. This technique can be performed without upper eyelid eversion, which makes it more tolerable for patients and less complex for the operator compared to the transconjunctival injection approach. Our results show a significant improvement in MRD1 and UER, as well as patient QOL. Moreover, we found a low rate of complications (4.2% induced ptosis) and no cases of raised intraocular pressure. Percutaneous TA injection can greatly reduce the need for eyelid lowering surgery in this patient population.
Efficacy and safety of FLT3 inhibitors in monotherapy of hematological and solid malignancies: a systemic analysis of clinical trials
Authors: Zhao Yuying , Zhang Xuedi , Ding Xiaoyan , Wang Ying , Li Zhenpeng , Zhao Ronglan , Cheng Hai-En , Sun Yanli 
Published: May 2024

Introduction: FLT3 mutations are closely associated with the occurrence of hematological and solid malignancies, especially with acute myeloid leukemia. Currently, several FLT3 inhibitors are in clinical trials, and some have been applied in clinic. However, the safety, efficacy and pharmacodynamics of these FLT3 inhibitors have not been systemically analyzed before.Methods: We searched and reviewed clinical trial reports on the monotherapy of 13 FLT3 inhibitors, including sorafenib, lestaurtinib, midostaurin, gilteritinib, quizartinib, sunitinib, crenolanib, tandutinib, cabozantinib, pexidartinib, pacritinib, famitinib, and TAK-659 in patients with hematological and solid malignancies before May 31, 2023.Results: Our results showed the most common adverse events (AEs) were gastrointestinal adverse reactions, including diarrhea, hand-foot syndrome and nausea, while the most common hematological AEs were febrile neutropenia, anemia, and thrombocytopenia. Based on the published data, the mean overall survival (OS) and the mean progression-free survival (PFS) were 9.639 and 5.905 months, respectively. The incidence of overall response rate (ORR), complete remission (CR), partial response (PR), and stable disease (SD) for all these FLT3 inhibitors was 29.0%, 8.7%, 16.0%, and 42.3%, respectively. The ORRs of FLT3 inhibitors in hematologic malignancies and solid tumors were 40.8% and 18.8%, respectively, indicating FLT3 inhibitors were more effective for hematologic malignancies than for solid tumors. In addition, time to maximum plasma concentration (Tmax) in these FLT3 inhibitors ranged from 0.7-12.0 hours, but the elimination half-life (T1/2) range was highly variable, from 6.8 to 151.8 h.Discussion: FLT3 inhibitors monotherapy has shown significant anti-tumor effect in clinic, and the effectiveness may be further improved through combination medication.
Treating refractory obsessive compulsive disorder with cathodal transcranial direct current stimulation over the supplementary motor area: a large multisite randomized sham-controlled double-blind study
Authors: Harika-Germaneau Ghina , Heit Damien , Drapier Dominique , Sauvaget Anne , Bation Remy , Chatard Armand , Doolub Damien , Wassouf Issa , Langbour Nicolas , Jaafari Nematollah 
Published: May 2024

BackgroundThe present study evaluated the therapeutic efficacy and tolerability of 10 transcranial direct current stimulation (tDCS) sessions in treatment-resistance obsessive-compulsive disorder (OCD) patients using a multisite double-blind sham-controlled design.MethodsEighty treatment-resistance outpatients suffering from obsessive-compulsive disorder were randomized to receive either active or sham transcranial direct current stimulation. The cathode was positioned over the supplementary motor area and the anode over the right supraorbital area. Patients were evaluated at baseline, end of treatment (day 14), one-month follow-up (day 45), and three-month follow-up (day 105) on the Yale-Brown Obsessive Compulsive Scale.ResultsAlthough a significant interaction between time and treatment was observed, the primary endpoint—measuring the change in Yale-Brown obsessive compulsive scale scores after two weeks—was not achieved. Conversely, the secondary endpoint, which concerned the change in Yale-Brown obsessive compulsive scale scores after three months, was successfully met. It is important to note, however, that there were no significant differences in the percentage of responders and remitters at any of the post-treatment assessments. This suggests that the treatment may not have had a clinically relevant impact. Patients well received the transcranial direct current stimulation treatment, indicating its good tolerability.ConclusionThis is the largest controlled trial using transcranial direct current stimulation in treatment-resistance obsessive-compulsive disorder patients. Our results indicate the importance of studying the placebo effect in transcranial direct current stimulation and the necessity to consider a long follow-up time to best evaluate the effects of the intervention.Clinical trial registrationClinicalTrials.gov, identifier NCT03304600.
The relationship between mobile phone dependence and academic burnout in Chinese college students: a moderated mediator model
Authors: Li Na , Fu Linxi , Yang Hewen , Zhao Wanting , Wang Xingbo , Yan Yingchun , Fu Yangyang 
Published: May 2024

ObjectiveThe aim of this study was to examine the correlation between the level of mobile phone dependence among college students and their experience of academic burnout. Additionally, the study sought to explore the potential mediating effect of study engagement and the moderating role of love.MethodsDuring October and December 2023, a cross-sectional study measuring mobile phone dependence, academic burnout, and study engagement among Chinese college students, using the UtrechtWork Engagement Scale-student (UWES-S), College Student Mobile Phone Dependence Questionnaire (CSMPDQ), and Academic Burnout Questionnaire (ABQ). To examine the hypothesis of mediating and moderating effect, SPSS PROCESS was utilized.ResultsThe predictive effect of mobile phone dependence on academic burnout was significant (β = 0.410, t = 14.236, p &lt; 0.001), and the predictive effect of mobile phone dependence on academic burnout remained significant when the mediating variable study engagement was introduced (β = 0.308, t = 10.288, p &lt; 0.001), mobile phone dependence had a significant predictive effect on study engagement (β = -0.292, t = -11.639, p &lt; 0.001), and study engagement had a significant positive predictive effect on academic burnout (β = -0.270, t = -9.028, p &lt; 0.001). Love significantly negatively predicted study engagement (β = -0.564, t = -9.641, p &lt; 0.001); and the interaction term for mobile phone dependence and love was significant (β = -0.211, t = -3.688, p &lt; 0.001), indicating a significant moderating effect of love between mobile phone dependence and study engagement.ConclusionMobile phones among college students has been found to have a direct correlation with academic burnout. It can also indirectly contribute to academic burnout by diminishing levels of academic engagement. This indirect relationship is further influenced by love. These findings can help researchers and educators better understand the underlying mechanisms between smartphone dependence and learning burnout in undergraduates.
Program Rumah Cerdas Kesehatan sebagai Upaya Peningkatan Literasi Kesehatan Masyarakat Desa Mallongi-Longi
Authors: Hidayah Nurul , Assagaf Said Fachry , Abdullah Adib Roisilmi , Iqbal Muhammad , Herman Herman 
Published: May 2024

Literasi kesehatan adalah pemahaman dan penerapan informasi tentang perawatan kesehatan yang dibutuhkan dalam mengambil keputusan. Definisi ini menunjukkan bahwa peningkatan literasi kesehatan mengarah pada pemahaman yang lebih baik tentang keputusan sehari-hari yang berkaitan dengan Kesehatan. hasil observasi yang dilakukan oleh tim PPK Ormawa HMJ Matematika FMIPA UNM, terdapat beberapa permasalahan yang diperoleh salah satunya yaitu kurangnya pengetahuan warga desa Mallongi Longi terkait kesehatan. Terkhusus anak-anak yang berusia 7 hingga 15 tahun. Warga Desa Mallongi Longi masih belum mengetahui dan kurang paham mengenai hal-hal dasar yang berkaitan dengan kesehatan, seperti cara mencuci tangan yang baik dan benar, cara menggosok gigi dengan benar, dan hal-hal yang berkaitan dengan Kesehatan lainnya. Begitupun masyarakat desa yang berusia 20 tahun keatas pun masih sangat minim pengetahuan mengenai Kesehatan sehingga tim PPK Ormawa HMJ Matematika FMIPA UNM membuat salah satu program, yaitu “Program Rumah Cerdas Kesehatan” yang dimana terdapat 5 program utama yakni festival kesehatan, kelas kesehatan anak, edukasi kesehatan, fun day, dan poster kesehatan. Program ini mampu menjawab kebutuhan masyarakat terkait dengan perluasan wawasan kesehatan. Kata Kunci: Rumah Cerdas, Literasi, Kesehatan, Masyarakat.
Effect of Different Feeds on Growth Rate and Survival of Common Carp (Cyprinus carpio L.) Larvae
Authors: Mojer Ahmed M. , Al-Dubakel Adel Y. 
Published: May 2024

The present study was conducted to evaluate the growth and survival rates of common carp (Cyprinus carpio) larvae fed different diets levels in laboratory Two-day-old larvae were transferred from the University of Basrah Marine Science Center hatchery to the Abi Al-Khaseeb district's experiment laboratory. The larvae were distributed into four treatments 450 larvae each treatment (150 larvae per replicate and three replicates per treatment) at a stock density of 3.33 larvae /L. The treatments were as follows: T1 was given boiling egg yolks; T2 was given a processed diet with 45% protein; T3 was given Redi-Lac milk powder; and T4 was given ground Artemia eggs. The experiment ran for 20 days, beginning on April 17, 2022.The results showed that larvae fed on diet containing ground Artemia eggs (T4) produced the highest final weight (39.667mg), followed by a diet containing 45% protein processed diet (T2), , Redi-Lac milk powder food (T3), and boiled egg yolks food (T1) produced the lowest final weight ( 27.333 and 24.667 mg, respectively) Statistical analysis revealed a significant difference (P≤0.05) in the final weight, weight gain, daily growth rate, relative growth rate and specific growth rate between T4 and T1, but not between T4 and T2 and between T4 and T3. The survival rate showed a significant difference (P≤0.05) between T4 (0.71%) and other treatments. Our results suggest that ground Artemia eggs is the most suitable and optimal meal for common carp fish larvae.
Pinus densiflora var. ussuriensis Forest Alliance
Authors: Zhang Yutong , Sui Yuzhu , Wang Hongfeng , Jin Guangze 
Published: May 2024

Pinus densiflora var. ussuriensis forest is a pine forest type unique to the northeast region of China, with a special habitat, strong barrenness and drought resistance, and normal growth under super-reversible ground conditions, as well as important ecological benefits such as water conservation, improvement of soil conditions, windbreaks and sand fixation, making it an important pioneer tree species for improving ground conditions. The paper through the natural distribution of China's Pinus densiflora var. ussuriensis forest field survey, combined with literature, the geographical distribution of Pinus densiflora var. ussuriensis forest, ecological characteristics, community characteristics, species composition and type division of the systematic analysis, the main results:
(1) According to 11 sample squares survey statistics, the natural Pinus densiflora var. ussuriensis forest recorded a total of 142 species of vascular plants, belonging to 55 families and 104 genera. Among them, there are 2 species of ferns, 1 species of gymnosperms and 139 species of angiosperms.
(2) The number of terrestrial herbs in the life type composition of the Pinus densiflora var. ussuriensis forest is the highest, followed by woody plants, and the proportion of bryophytes is the least.
(3) The Pinus densiflora var. ussuriensis forest located at the lake post of Xing Kai Lake is in a period of decline, and if the soil in the area continues to be moisturized, the cluster may eventually evolve into a broad-leaved mixed forest.
(4) According to the life type and dominant species, the Pinus densiflora var. ussuriensis forest can be divided into 2 clusters.
Effect of HLA Genotype on Anti-PD-1 Antibody Treatment for Advanced Renal Cell Carcinoma in the SNiP-RCC Study
Authors: Tanegashima Tokiyoshi , Shiota Masaki , Fujiyama Nobuhiro , Narita Shintaro , Habuchi Tomonori , Fukuchi Genshiro , Takamatsu Dai , Oda Yoshinao , Miyake Hideaki , Takahashi Masayuki , Oya Mototsugu , Tsuchiya Norihiko , Masumori Naoya , Matsuyama Hideyasu , Obara Wataru , Shinohara Nobuo , Fujimoto Kiyohide , Nozawa Masahiro , Ohba Kojiro , Ohyama Chikara , Hashine Katsuyoshi , Akamatsu Shusuke , Kamba Tomomi , Mita Koji , Gotoh Momokazu , Tatarano Shuichi , Fujisawa Masato , Tomita Yoshihiko , Mukai Shoichiro , Ito Keiichi , Tokunaga Shoji , Eto Masatoshi 
Published: May 2024

Abstract
Immune checkpoint blockade therapies are widely used for cancer treatment, including advanced renal cell carcinoma (RCC). This study aimed to investigate the impact of zygosity in HLA genes and individual HLA genotypes on the efficacy of an anti-PD-1 Ab, nivolumab, in treating advanced RCC. Patient enrollment was conducted across 23 institutions in Japan from August 19, 2019, to September 30, 2020, with follow-up concluding on March 31, 2021. HLA genotype imputation of HLA-A, B, and C, DQB1, and DRB1 loci was performed. Among 222 patients, the presence of at least one homozygosity of the HLA-II allele significantly improved the best objective response (hazard ratio, 0.34; 95% confidence interval, 0.21–0.96; p = 0.042). The HLA evolutionary divergence (HED) of the HLA-A and HLA-B loci was higher than the HLA-C (p &lt; 0.0001 and p &lt; 0.0001, respectively), with high HED of the HLA-B locus correlating to clinical benefits in nivolumab treatment (hazard ratio, 0.44; 95% confidence interval, 0.21–0.90; p = 0.024) and improving cancer-specific survival compared with the low group (p = 0.0202). Additionally, high HED of the HLA-B locus was correlated with the number of infiltrated CD8+ cells in the tumor microenvironment (correlation coefficient, 0.4042). These findings indicate that the diversity of the HLA-B locus plays a significant role in the anti-tumor effect of nivolumab treatment in advanced RCC, potentially offering insights for improved risk stratification in nivolumab treatment and leading to better medical management of advanced RCC.