bluuebunny/crossref_metadata_2025_split huggingface dataset:
Langerhans’s cell histiocytosis in old subjects: two rare case reports and review of the literature
Authors: Lajolo Carlo , Campisi Giuseppina , Deli Giorgio , Littarru Cristiano , Guiglia Rosario , Giuliani Michele 
Published: May 2012

doi: 10.1111/j.1741‐2358.2012.00629.xLangerhans’s cell histiocytosis in old subjects: two rare case reports and review of the literatureBackground:  Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte‐like cells that generally affects children; LCH onset is rare in adults; immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial.Objective:  To describe two new cases of adult onset oral LCH.Case reports:  Case 1: a 71‐year‐old woman, complaining of diffuse oral pain, presented with erythematous mucosal lesions; the panoramic radiograph and CT scan showed multiple mandible radiolucent areas. Immunohistochemical assay for S‐100, CD1a and langerin test was essential in reaching the correct diagnosis. Case 2: a 77‐year‐old female patient presented with a non‐painful, non‐bleeding, slightly elevated erythematous palatal lesion of 6 months duration, together with a genital vulvar lesion of uncertain nature. The pathology confirmed the diagnosis of LCH. Many therapies (etoposid, radiotherapy) could induce only a clinical partial remission; Cladribine induced a complete recovery.Conclusion:  The first case was difficult to diagnose: the clinical presentation and course of the disease (LCH) in the elderly are multiple and unpredictable. An immunohistochemistry study is often essential to obtain the correct diagnosis. The second case required several therapeutic interventions: even though some cases regress spontaneously, others require systemic chemotherapy.
Cytotoxic effects of denture adhesives on primary human oral keratinocytes, fibroblasts and permanent L929 cell lines
Authors: Chen Fengying , Wu Tianfu , Cheng Xiangrong 
Published: May 2012

BackgroundTo date, there have been very little data on the cytotoxic responses of different cell lines to denture adhesives.ObjectiveTo determine the cytotoxicity of three denture adhesives on primary human oral keratinocytes (HOKs), fibroblasts (HOFs) and permanent mouse fibroblasts cell lines (L929).MethodsThree commercial denture adhesives (two creams and one powder) were prepared for indirect contact using the agar diffusion test, as well as extracts in MTT assay. The results of the MTT assay were statistically analysed by one‐way anova and Tukey's test (p < 0.05).ResultsAll of the tested denture adhesives showed mild to moderate cytotoxicity to primary HOKs (p < 0.001), whereas none of three was toxic to L929 cells (p > 0.05) in both assays. For primary HOFs cultures, slight cytotoxicity was observed for one of the products from the agar diffusion test and undiluted eluates of all tested adhesives with MTT assay (p < 0.01).ConclusionDenture adhesives are toxic to the primary HOKs and HOFs cultures, whereas non‐toxic to L929 cells. The results suggest that primary human oral mucosal cells may provide more valuable information in toxicity screening of denture adhesives.
Factors Associated with Higher Fecundity in Female Maternal Relatives of Homosexual Men
Authors: Camperio Ciani Andrea S. , Fontanesi Lilybeth , Iemmola Francesca , Giannella Elga , Ferron Claudia , Lombardi Luigi 
Published: May 2012

ABSTRACT

Introduction
Recent evidence suggests that sexually antagonistic genetic factors in the maternal line promote homosexuality in men and fecundity in female relatives. However, it is not clear if and how these genetic factors are phenotypically expressed to simultaneously induce homosexuality in men and increased fecundity in their mothers and maternal aunts.

Aims
The aim of the present study was to investigate the phenotypic expression of genetic factors that could explain increased fecundity in the putative female carriers.

Methods
Using a questionnaire-based approach, which included also the Big Five Questionnaire personality inventory based on the Big Five theory, we investigated fecundity in 161 female European subjects and scrutinized possible influences, including physiological, behavioral, and personality factors. We compared 61 female probands who were either mothers or maternal aunts of homosexual men. One hundred females who were mothers or aunts of heterosexual men were used as controls.

Main Outcome Measures
Personality traits, retrospective physiological and clinical data, behavior and opinions on fecundity-related issues were assessed and analyzed to illustrate possible effects on fecundity between probands and control females.

Results
Our analysis showed that both mothers and maternal aunts of homosexual men show increased fecundity compared with corresponding maternal female relatives of heterosexual men. A two-step statistical analysis, which was based on t-tests and multiple logistic regression analysis, showed that mothers and maternal aunts of homosexual men (i) had fewer gynecological disorders; (ii) had fewer complicated pregnancies; (iii) had less interest in having children; (iv) placed less emphasis on romantic love within couples; (v) placed less importance on their social life; (vi) showed reduced family stability; (vii) were more extraverted; and (viii) had divorced or separated from their spouses more frequently.

Conclusions
Our findings are based on a small sample and would benefit from a larger replication, however they suggest that if sexually antagonistic genetic factors that induce homosexuality in males exist, the factors might be maintained in the population by contributing to increased fecundity greater reproductive health, extraversion, and a generally relaxed attitude toward family and social values in females of the maternal line of homosexual men.
Effects of lactic acid bacteria and urea treatment on fermentation quality, digestibility and ruminal fermentation of roll bale rice straw silage in wethers
Authors: Fang Jiachen , Matsuzaki Masatoshi , Suzuki Hiroyuki , Cai Yimin , Horiguchi Ken‐ichi , Takahashi Toshiyoshi 
Published: May 2012

AbstractThe digestibility, nitrogen retention and ruminal fermentation of dry rice straw (DRS), untreated rice straw silage (NRS), lactic acid bacteria (LAB) treated rice straw silage (LRS) and urea treated rice straw silage (URS) were compared in a feeding trial with wethers supplemented with concentrate. Both NRS and LRS provided good fermentation quality although the lactic acid content in LRS was higher than in NRS (P < 0.05). The digestibility of the feed component did not differ among DRS, NRS and LRS treatments; however, the digestibility of crude protein (CP), acid detergent fiber (ADFom), neutral detergent fiber (NDFom) and energy increased in the URS treatment (P < 0.05). With the increase in digestibility, the nutritive values of digestible crude protein (DCP) and digestible energy (DE) also increased in URS treatment (P < 0.05). The high urinary excretion of nitrogen (N) with URS treatment did not influence its improved N retention compared with the other treatments (P < 0.05). The higher ruminal total volatile fatty acid (VFA) and ratio of acetate to propionate (A:P) in ruminal fluid of wethers following URS treatment (P < 0.05) indicated that the urea treatment resulted in effective ruminal fermentation. These results show that although LAB treatment can improve fermentation quality, it had no effect on the digestibility of feed components. Urea was an effective treatment for improving digestibility, N retention and ruminal fermentation.
Organic carbon stocks in grassland soils and their spatial distribution in Japan
Authors: Matsuura Shoji , Sasaki Hiroyuki , Kohyama Kazunori 
Published: May 2012

AbstractTo evaluate the nationwide status of grasslands and their soil organic carbon stocks in Japan, we used 1990 as a base year and estimated: (i) the area and the spatial distribution of grasslands, and (ii) the size and the spatial distribution of their soil organic carbon stocks. The carbon stocks were estimated to a 30 cm depth based on datasets containing information on vegetation, wetlands, soils and land classifications. The total grassland area (including natural grasslands, semi‐natural grasslands, meadows/pastures and artificial grasslands for non‐agricultural use) was estimated at 18 700 km2, which is 5.0% of Japan’s total land area. Nearly two‐thirds of the total grassland area contained Andosols or Brown Forest soils, and the percentage of area covered by each soil group differed with grassland type. The estimated soil organic carbon density value (11.4 kg C m–2 for all Japanese grasslands) was consistent with previously reported values (4.0–20.2 kg C m–2 for several Japanese grasslands). A map of the soil organic carbon stocks in grasslands shows a characteristic distribution of high and low carbon stock areas. The total estimated carbon stock in grassland topsoils was 214 Tg C, which is 8.0% of the total carbon stock in Japanese topsoils. The techniques used and the results obtained in this study are valuable for the evaluation of future changes in soil organic carbon stocks in Japan. To obtain more accurate and comprehensive estimates of these changes, it is important to develop the unified grassland categorization system and to collect soil organic carbon data for several types of grasslands, at least meadows/pastures and semi‐natural grasslands for agricultural use.
Exceptionally high fertility observed in three F1 hybrids between Lolium multiflorum Lam. and L. temulentum L.
Authors: Kiyoshi Takako , Arakawa Akira , Uchiyama Kazuhiro , Fujimori Masahiro , Mizuno Kazuhiko , Cai Hongwei 
Published: May 2012

AbstractThe pollen fertility and seed set of three F1 hybrid plants derived from a cross between a darnel ryegrass (Lolium temulentum L.) line (Ba3081) and a genotype of Italian ryegrass (L. multiflorum Lam.) were evaluated in field and greenhouse experiments under different temperatures. In the field where the daily mean temperature for 3 weeks prior to pollen dispersal was 16.5°C, the mean pollen fertility of the F1 plants was 42.8%, which was lower than the value observed in the parental species (96.0–98.1%). In two greenhouses with a daily mean temperature of 20.4 and 15.8°C, the mean pollen fertility of the F1 plants was 53.1% and 44.0%, respectively, which were higher than the values reported previously for the hybrids between L. temulentum × L. multiflorum (maximum of about 20%). The seed set of the F1 plants was 24% under open‐pollinated conditions in the field compared with 4.2–8.8% under self‐pollinated conditions in the two greenhouses. These results indicated that the F1 plants were self‐fertile and able to set F2 seed, with a significant reduction in pollen fertility occurring with a decrease in the daily mean temperature (2.15% decrease in fertility per unit decrease in temperature). The germination rate of the F2 seeds was approximately 57%, indicating the possibility of producing an F2 population for future genetic analysis. This is the first report of F1 plants from L. temulentum × L. multiflorum with fertile pollen and with the ability to produce progeny by self‐pollination. These findings suggest a possibility of developing recombinant inbred lines between L. temulentum and L. multiflorum.
Assessing Consumers’ Willingness to Pay for Different Units of Organic Milk: Evidence from Multiunit Auctions
Authors: Akaichi Faical , Nayga, Jr Rodolfo M. , Gil José M. 
Published: May 2012

Experimental auctions are normally conducted using single‐unit auctions. In this paper, we use the multiunit Vickrey auction to assess the determinants of consumers’ willingness to pay (WTP) for organic milk in a multiunit shopping scenario. We also analyze the effect of positive and negative information about organic farming on WTP. Our results suggest that consumers are willing to pay a premium for organic milk but that this WTP decreases with the number of units purchased. Results also suggest that health issues, high price of organic foods, taste, and lack of information on organic foods are factors that influence WTP for organic milk. The type of information provided also plays a relevant role. Specifically, we found that subjects’ WTP responds positively to positive information about organic farming and responds negatively to negative information. The provision of both positive and negative information does not affect WTP.Les enchères expérimentales sont en règle générale effectuées sous un cadre d’enchères de Vickrey à une seule unité. Dans le présent article, nous avons utilisé l’enchère de Vickrey à unités multiples pour évaluer les déterminants du consentement à payer (CAP) des consommateurs pour du lait biologique dans un contexte d’achats multiples. Nous avons également examiné les répercussions que l’information positive et négative à l’égard de l’agriculture biologique a sur le CAP. Nos résultats autorisent à penser que les consommateurs sont prêts à payer un prix plus élevé pour obtenir du lait biologique, mais que ce CAP diminue avec le nombre d’unités achetées. Nos résultats autorisent aussi à penser que les aspects liés à la santé, le prix élevé des aliments biologiques, le goût et le manque d’information sur ces aliments sont des facteurs qui influencent le CAP pour du lait biologique. Le type d’information joue également un rôle important. Nous avons observé que le CAP réagit favorablement à de l’information positive sur l’agriculture biologique et défavorablement à de l’information négative. La diffusion simultanée d’information positive et négative n’influence pas le CAP.
RAMSES-CH: a new chemodynamical code for cosmological simulations
Authors: Few C. G. , Courty S. , Gibson B. K. , Kawata D. , Calura F. , Teyssier R. 
Published: May 2012

Abstract
We present a new chemodynamical code –ramses-ch– for use in simulating the self-consistent evolution of chemical and hydrodynamical properties of galaxies within a fully cosmological framework. We build upon the adaptive mesh refinement code ramses, which includes a treatment of self-gravity, hydrodynamics, star formation, radiative cooling and supernova feedback, to trace the dominant isotopes of C, N, O, Ne, Mg, Si and Fe. We include the contribution of Type Ia and Type II supernovae, in addition to low- and intermediate-mass asymptotic giant branch stars, relaxing the instantaneous recycling approximation. The new chemical evolution modules are highly flexible and portable, lending themselves to ready exploration of variations in the underpinning stellar and nuclear physics. We apply ramses-ch to the cosmological simulation of a typical L★ galaxy, demonstrating the successful recovery of the basic empirical constraints regarding [α/Fe]–[Fe/H] and Type Ia/II supernova rates.
Detection of gravity modes in the massive binary V380 Cyg from Kepler space-based photometry and high-resolution spectroscopy
Authors: Tkachenko A. , Aerts C. , Pavlovski K. , Southworth J. , Degroote P. , Debosscher J. , Still M. , Bryson S. , Molenberghs G. , Bloemen S. , de Vries B. L. , Hrudkova M. , Lombaert R. , Neyskens P. , Pápics P. I. , Raskin G. , Van Winckel H. , Morris R. L. , Sanderfer D. T. , Seader S. E. 
Published: May 2012

Abstract
We report the discovery of low-amplitude gravity-mode oscillations in the massive binary star V380 Cyg, from 180 d of Kepler custom-aperture space photometry and 5 months of high-resolution high signal-to-noise ratio spectroscopy. The new data are of unprecedented quality and allowed the improvement of the orbital and fundamental parameters for this binary. The orbital solution was subtracted from the photometric data and led to the detection of periodic intrinsic variability with frequencies, of which some are multiples of the orbital frequency and others are not. Spectral disentangling allowed the detection of line-profile variability in the primary. With our discovery of intrinsic variability interpreted as gravity-mode oscillations, V380 Cyg becomes an important laboratory for future seismic tuning of the near-core physics in massive B-type stars.
Role of the laboratory in monitoring patients receiving dual antiplatelet therapy
Authors: VIDALI M. , ROLLA R. , PARRELLA M. , CASSANI C. , MANZINI M. , PORTALUPI M. R. , SERINO R. , PRANDO M. D. , BELLOMO G. , PERGOLINI P. 
Published: May 2012

SummaryIntroduction:  The increasing demand for therapeutic monitoring in patients receiving antiplatelet therapy has been paralleled by the development of instruments and tests whose clinical usefulness is still under debate. We devised a laboratory approach to detect patients with antiplatelet resistance at risk to develop thrombotic events.Methods:  One hundred and eighty patients, under aspirin and clopidogrel after angioplasty and stent implantation, were studied by PFA100® with collagen/epinephrine (CoEPI, cutoff 165s) cartridge and by Multiplate® using arachidonic acid (ASPItest, pos < 862AUC), ADP (ADPtest, pos < 417AUC), and collagen (COLtest, pos < 607AUC).Results:  Only 67 of 173 patients with ASPI < 862 displayed a prolonged CoEPI and up to 65 patients had normal CoEPI despite ASPI < 300. Patients with ASPI < 300 had significantly lower COL than patients with ASPI > 300. One hundred and thirty‐eight patients displaying ADP < 417 had significantly lower COL than those with ADP > 417. Association between COL and ADP remained after ASPI stratification: in patients with suboptimal (ASPI 300–892) or maximal (ASPI < 300) response to aspirin, having ADP < 417 (clopidogrel responsive) increased COL positivity, respectively, from 9.5 to 58.8% and from 47.6 to 82.7%.Conclusion:  A combination of specific tests may be useful in identifying higher‐risk patients with poor compliance or drug resistance who potentially may benefit from therapy change.
Seawater Intrusion and Sustainable Yield of Basal Aquifers1
Authors: Liu Clark C.K. , Dai John J. 
Published: May 2012

Liu, Clark C.K. and John J. Dai, 2012. Seawater Intrusion and Sustainable Yield of Basal Aquifers. Journal of the American Water Resources Association (JAWRA) 48(5): 861‐870. DOI: 10.1111/j.1752‐1688.2012.00659.xAbstract:  Basal aquifers, in which freshwater floats on top of saltwater, are the major freshwater supply for the Hawaiian Islands, as well as many other coastal regions around the world. Under unexploited or natural conditions, freshwater and the underlying seawater are separated by a relatively sharp interface located below mean sea level at a depth of about 40 times the hydraulic head. With forced draft, the hydraulic head of a basal aquifer would decline and the sharp interface would move up. It is a serious problem of seawater intrusion as huge amounts of freshwater storage is replaced by saltwater. Also, with forced draft, the sharp interface is replaced by a transition zone in which the salinity increases downward from freshwater to saltwater. As pumping continues, the transition zone expands. The desirable source‐water salinity in Hawaii is about 2% of the seawater salinity. Therefore, the transition zone expansion is another serious problem of seawater intrusion. In this study, a robust analytical groundwater flow and salinity transport model (RAM2) was developed. RAM2 has a simple mathematical structure and its model parameters can be determined satisfactorily with the available field monitoring data. The usefulness of RAM2 as a viable management tool for coastal ground water management is demonstrated by applying it to determine the sustainable yield of the Pearl Harbor aquifer, a principal water supply source in Hawaii.
The Uncoupling Protein 2 ‐866G > A Polymorphism is Associated with the Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients
Authors: Chai Yi , Gu Bing , Qiu Jin‐Rong , Yi Hong‐Gang , Zhu Qian , Zhang Lu , Hu Gang 
Published: May 2012

SUMMARY Aims: To determine genetic predispsitions for diabetic cerebral ischemia, we investigated the relationship between the ‐866G>A polymorphism of uncoupling protein (UCP) 2 and the risk of ischemic stroke in two cohorts of type 2 diabetic patients. Methods: A total of 844 type 2 diabetic patients with 4‐year prospective study were examined using a case‐control methodology. And 404 cases with ischemical stroke, 440 cases without ischemical stroke. The ‐866G>A polymorphism in UCP2 was genotyped by TaqMan MGB probe method. Results: The ‐866G>A SNP in UCP2 was significantly associated with diabetic ischemical stroke (odds ratio [OR]= 1.94; 95% confidence interval [CI]= 0.68 to1.31; P < 0.037). Similar results were observed for baseline cases of IS. Stratification by sex confirmed an allelic association with IS in women, whereas no association was observed in men. Conclusions: The A allele of the ‐866G>A variant of UCP2 was associated with increased risk of IS in Chinese diabetic women with type 2 diabetes in a 4‐year prospective study. This association was independent of other common IS risk factors.
Effect of Pregnancy and Obesity on Arch of Foot
Authors: Dunn John , Dunn Christina , Habbu Rohan , Bohay Donald , Anderson John 
Published: May 2012

ObjectiveEndocrine changes occurring during pregnancy result in increased laxity of the ligaments of the foot. This may lead to gradual collapse of the foot arches. The aim of the study was to determine whether pregnancy and body mass index (BMI) had a role in affecting the foot arches at long term.MethodsA collapsed arch results in widening of the feet, thus altering the foot size. The control group included nulliparous women, while the study group included women who had been pregnant at least once. The groups were stratified secondarily by obesity according to BMI. We reviewed over 1000 charts at the outpatient offices in a large Mid‐Western city. The age, BMI, and shoe size in an athletic shoe were recorded.ResultsThere were 40 subjects in the control group and 70 in the study group. 19/40 women in control and 46/70 in study group experienced a change in shoe size (P = 0.06). Of those affected, the non‐obese control group experienced a 9.7% change in shoe size while the obese study group experienced a 15.5% change (P < 0.05).ConclusionThere was neither a change in size between women who had been pregnant and the nulliparous, nor was there a difference between the obese and non‐obese. However, there was a statically significant difference between those affected who were both non‐obese and nulliparous and those who had been pregnant and who are obese. Individually, the effect of pregnancy and BMI are highly suggestive and clinically relevant.
Slope on Proximal Tibiofibular Articular Surface with 3‐D Reconstruction by 64‐Slice Computed Tomography on Human
Authors: Zhang Yin‐wang , Deng Hong‐zhen , Zhu Hai‐bo , Zhu Yi , Zhu Jian‐ming 
Published: May 2012

ObjectiveUsing 64‐slice spiral CT to reconstruct virtual knee joints of adults, we measured the gradient of proximal tibia‐fibular joint and compared this result with bare joint measurement. We then discuss the accuracy of these measurements using a 64‐slice spiral CT.MethodsTwo hundred healthy adults were selected, including 100 males and 100 females, aged from 18 to 90 years. The gradient of the longitudinal axis of the fibula and the articular surface, and the angle of horizon of the proximal tibia‐fibular articular surface and the horizontal line were measured by using a 64‐slice spiral CT scan.ResultsThe angle between the longitudinal axis of the fibula and the articular surface (angle A) was 56.80° ± 6.59°, both the left and the right fibula showed no significant difference (t = 0.308, P = 0.758). The angle between horizontal line and the articular surface (angle B) was 32.80° ± 6.49°. The regression or correlation analysis findings showed that there is a negative relationship (r = −0.952, P = 0.000), and there is significant difference (t = 51.87, P < 0.01) between the angle A and the angle B.ConclusionThe measurement value of using 64‐slice spiral CT to reconstruct the slope of proximal tibia‐fibular joints has no difference compared to the measurement value of the slope of bare proximal tibia‐fibular joints. It is a precise, convenient method and is easy to apply for clinical study.