bluuebunny/crossref_metadata_2025_split huggingface dataset:
Premature Ovarian Failure and Fertility in Long-Term Survivors of Hodgkin's Lymphoma: A European Organisation for Research and Treatment of Cancer Lymphoma Group and Groupe d'Étude des Lymphomes de l'Adulte Cohort Study
Authors: van der Kaaij Marleen A.E. , Heutte Natacha , Meijnders Paul , Abeilard-Lemoisson Edwige , Spina Michele , Moser Elizabeth C. , Allgeier Anouk , Meulemans Bart , Simons Arnold H.M. , Lugtenburg Pieternella J. , Aleman Berthe M.P. , Noordijk Evert M. , Fermé Christophe , Thomas José , Stamatoullas Aspasia , Fruchart Christophe , Brice Pauline , Gaillard Isabelle , Bologna Serge , Ong Francisca , Eghbali Houchingue , Doorduijn Jeanette K. , Morschhauser Franck , Sebban Catherine , Roesink Judith M. , Bouteloup Marie , Van Hoof Achiel , Raemaekers John M.M. , Henry-Amar Michel , Kluin-Nelemans Hanneke C. 
Published: December 2011

Purpose In this large cohort of Hodgkin's lymphoma survivors with long follow-up, we estimated the impact of treatment regimens on premature ovarian failure (POF) occurrence and motherhood, including safety of nonalkylating chemotherapy and dose-response relationships for alkylating chemotherapy and age at treatment. Patients and Methods The Life Situation Questionnaire was sent to 1,700 women treated in European Organisation for Research and Treatment of Cancer and Groupe d'Étude des Lymphomes de l'Adulte trials between 1964 and 2004. Women treated between ages 15 and 40 years and currently not using hormonal contraceptives (n = 460) were selected to assess occurrence of POF. Cumulative POF risk was estimated using the life-table method. Predictive factors were assessed by Cox regression analysis. Results Median follow-up was 16 years (range, 5 to 45 years). Cumulative risk of POF after alkylating chemotherapy was 60% (95% CI, 41% to 79%) and only 3% (95% CI, 1% to 7%) after nonalkylating chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine; epirubicin, bleomycin, vinblastine, and prednisone). Dose relationship between alkylating chemotherapy and POF occurrence was linear. POF risk increased by 23% per year of age at treatment. In women treated without alkylating chemotherapy at age younger than 32 years and age 32 years or older, cumulative POF risks were 3% (95% CI, 1% to 16%) and 9% (95% CI, 4% to 18%), respectively. If menstruation returned after treatment, cumulative POF risk was independent of age at treatment. Among women who ultimately developed POF, 22% had one or more children after treatment, compared with 41% of women without POF. Conclusion Nonalkylating chemotherapy carries little to no excess risk of POF. Dose-response relationships for alkylating chemotherapy and age at treatment are both linear. Timely family planning is important for women at risk of POF.
Double-Blind, Randomized Trial of Docetaxel Plus Vandetanib Versus Docetaxel Plus Placebo in Platinum-Pretreated Metastatic Urothelial Cancer
Authors: Choueiri Toni K. , Ross Robert W. , Jacobus Susanna , Vaishampayan Ulka , Yu Evan Y. , Quinn David I. , Hahn Noah M. , Hutson Thomas E. , Sonpavde Guru , Morrissey Stephanie C. , Buckle Geoffrey C. , Kim William Y. , Petrylak Daniel P. , Ryan Christopher W. , Eisenberger Mario A. , Mortazavi Amir , Bubley Glenn J. , Taplin Mary-Ellen , Rosenberg Jonathan E. , Kantoff Philip W. 
Published: December 2011

Purpose Vandetanib is an oral once-daily tyrosine kinase inhibitor with activity against vascular endothelial growth factor receptor 2 and epidermal growth factor receptor. Vandetanib in combination with docetaxel was assessed in patients with advanced urothelial cancer (UC) who progressed on prior platinum-based chemotherapy. Patients and Methods The primary objective was to determine whether vandetanib 100 mg plus docetaxel 75 mg/m2 intravenously every 21 days prolonged progression-free survival (PFS) versus placebo plus docetaxel. The study was designed to detect a 60% improvement in median PFS with 80% power and one-sided α at 5%. Patients receiving docetaxel plus placebo had the option to cross over to single-agent vandetanib at progression. Overall survival (OS), overall response rate (ORR), and safety were secondary objectives. Results In all, 142 patients were randomly assigned and received at least one dose of therapy. Median PFS was 2.56 months for the docetaxel plus vandetanib arm versus 1.58 months for the docetaxel plus placebo arm, and the hazard ratio for PFS was 1.02 (95% CI, 0.69 to 1.49; P = .9). ORR and OS were not different between both arms. Grade 3 or higher toxicities were more commonly seen in the docetaxel plus vandetanib arm and included rash/photosensitivity (11% v 0%) and diarrhea (7% v 0%). Among 37 patients who crossed over to single-agent vandetanib, ORR was 3% and OS was 5.2 months. Conclusion In this platinum-pretreated population of advanced UC, the addition of vandetanib to docetaxel did not result in a significant improvement in PFS, ORR, or OS. The toxicity of vandetanib plus docetaxel was greater than that for vendetanib plus placebo. Single-agent vandetanib activity was minimal.
Safety and diagnostic image quality of iopromide: results of a large non-interventional observational study of European and Asian patients (IMAGE)
Authors: Palkowitsch Petra , Lengsfeld Philipp , Stauch Kathrin , Heinsohn Christian , Kwon Soon Tae , Zhang Shui-xing , Liang Chang-hong 
Published: December 2011

Background Iodine-based contrast agents such as iopromide play a central role in improving the diagnostic quality of imaging modalities using ionizing radiation. Purpose To investigate the safety and diagnostic image quality of iopromide in the routine clinical setting. Material and Methods This was an international, multicenter, prospective, single-arm, non-interventional study (NIS). The study was performed in out- and inpatients in 738 study centers in 21 countries in Europe and Asia. Iopromide was administered in a routine manner, in compliance with the local package insert. The use of premedication was at the discretion of the attending physician. Case report forms for 44,835 patients were analyzed (57.4% men). The median age of the patients was 55 years. Results For the vast majority of patients (94.8%), the contrast quality was rated as ‘good’ (55.8%) or ‘excellent’ (39.0%). For 1265 (2.8%) patients, there were reports of adverse drug reactions (ADRs) excluding tolerance indicators (TIs) (i.e. injection site warmth, feeling hot, or injection site pain of mild intensity). At least one ADR including TIs was reported in 2415 (5.4%) patients. There were 11 (0.02%) patients with serious ADRs, and no drug-related deaths. Events of injection site warmth and/or feeling hot were reported by 3.5%, nausea and/or vomiting by 0.96%, and urticaria, erythema, and/or rash by 0.54% of patients. Patients at risk for an acute idiosyncratic reaction (i.e. patients with a history of bronchial asthma, allergies, and/or contrast media reaction) had a higher incidence of ADRs compared with the overall study population. At-risk patients who did not receive premedication reported distinctly more ADRs compared with those who received premedication (12.0% versus 5.9%). Conclusion Iopromide was shown to be a well-tolerated contrast agent whose usage resulted in high image quality. No unknown ADRs were observed. Premedication with antiallergy drugs should be considered in at-risk patients.
Semantic structuring and nominalization processes: the case of agent and instrument nouns in Bantu languages
Authors: Ambadiang Théophile 
Published: December 2011

Abstract
The semantic relationship between derived agent and instrument nouns patterns in significantly diverse ways across human languages. Thus, for instance, in Germanic and Romance languages a correlation is commonly found between the semantic and formal affinity of agent and instrument nouns and processes of semantic extension which result in syncretism or polysemy. In contrast, some languages not only tend to constrain formal identity among derived nouns but also disallow processes of semantic extension. This is the case with the Bantu languages, in which derived agent and instrument nouns are formed in different noun classes whose classificatory function, together with the semantic content of noun prefixes, severely constrains the processes of semantic extension. We suggest that such semantic content, inseparable from the classificatory function of Bantu noun classes, accounts for this peculiarity. The lack of such content in Germanic and Romance derivational suffixes and inflectional endings explains, at least in part, their inability to constrain the semantics of verb bases with similar effects.
Polysemous agent nominals in Kambaata (Cushitic)
Authors: Treis Yvonne 
Published: December 2011

Abstract
Kambaata has a morpheme ­aan with which agent nominals can be derived from verbs and nouns. The present article discusses, firstly, the morphological and syntactic characteristics of ­aan nominals and the specific problem of which word class they should be assigned to. Secondly, it is shown that the -aan morpheme is multifunctional. Apart from agent nominals, it is used to derive instrument, place and patient nominals.
An Innocent Abroad? Caterina Galli's Finances in New Handel Documents
Authors: Duncan Cheryll , Mateer David 
Published: December 2011

Abstract
New documents relating to Handel and one of his singers have come to light at The National Archives in London. In a legal dispute between Caterina Galli and two of her servants, the singer provides an outline of her earnings for the period 1744–48 which mentions the names not only of Handel, but also of Francesco Geminiani, Niccolo Pasquali, and a “Mr Glooc” (almost certainly, Christoph Willibald Gluck). From the documents we learn of the singer's alleged extravagance and financial difficulties in London, her peripatetic lifestyle, and the probable reasons why she returned to the continent in 1754. They also add to our scant knowledge of singers' salaries and, in particular, record what Handel paid Galli for performing in his oratorios. The complainant's bill and interrogatories mention several significant patrons of the London music scene, and the defense's case is supported by a series of signed depositions, including one from John Christopher Smith the elder, Handel's secretary, treasurer, and principal copyist. Galli's claims to have sung for Handel as early as 1744 are examined and largely dismissed; nevertheless, the fees she says she earned are credible because they accord with Smith's testimony and the little we know about singers' salaries in the 1740s and 1750s.
Janáhček's Chronoscope
Authors: Steege Benjamin 
Published: December 2011

Abstract
Leoš Janáček's fascination with the trappings of experimental psychology has boosted his image as a kind of realist, for whom empirical engagement with psychological experience was a prerequisite for aesthetic value. Yet careful contextualization of the sources he drew upon in later years suggests that such discourses—above all, the work of Wilhelm Wundt—work ironically against the constitution of the expressive subjectivity we are used to inferring in his work. An emblematic case in point is Janáček's use of an experimental research instrument known as the “chronoscope,” which psychologists had traditionally used for studying reaction times, a formative concern for the discipline since its emergence in the 1870s. While remarkable for its utility in accurately measuring extremely short durations, the chronoscope also highlighted the temporal limits of perception. It appealed to the composer's obsession with minute details of sensation, but it can also be seen to raise questions about the integrity or continuity of the very image of subjectivity it was meant to ascertain. The conjunction of the chronoscope's dramatization of short timespans and Janáček's related concern for the calibrated gesture together suggest a mode of interpretation through which the expressive impulse in his music may be sensed as incipient, in a state of deferral, rather than as the immediate manifestation of an integral lyrical self.
Use of Palivizumab in Primary Practice
Authors: Perrin Keith M. , Bégué Rodolfo E. 
Published: December 2011

Objective:
To describe the implementation of a program for the use of palivizumab in a general pediatrics office and evaluate adherence to the 2009 American Academy of Pediatrics (AAP) guidelines.

Methods:
Pediatricians in a large practice were educated in the diagnosis and management of bronchiolitis, with specific attention to the AAP’s palivizumab administration guidelines. During the 2009–2010 and 2010–2011 respiratory syncytial virus seasons, children were systematically identified and enrolled for palivizumab administration. Indication for administration was determined by gestational age, age at the beginning of the respiratory syncytial virus season, pertinent diagnoses, and presence of risk factors.

Results:
In the 2009–2010 season, 161 children were enrolled to receive palivizumab, 86 of whom (53%) conformed with AAP guidelines. In contrast, in 2010–2011, a total of 85 children were enrolled to receive palivizumab, and 73 (86%) conformed with the guidelines. As a consequence, the total cost of palivizumab (US $: 511 559 vs 1 500 670) and the cost per child (US $: 6018 vs 9438) were lower in 2010–2011 than in 2009–2010. However, of the children selected within the AAP guidelines, only 29% received the appropriate number of doses, whereas 62% and 9% received fewer or excessive doses, respectively; these findings were similar for the 2 seasons.

Conclusions:
In a primary practice, use of palivizumab outside of the AAP guidelines was frequent and manifested as inadequate indications or inadequate number of doses. The former improved with education and standardization of care (suggesting provider problems), while the latter did not (suggesting system problems). Additional interventions are required.
Bovine Lactoferrin Prevents Invasive Fungal Infections in Very Low Birth Weight Infants: A Randomized Controlled Trial
Authors: Manzoni Paolo , Stolfi Ilaria , Messner Hubert , Cattani Silvia , Laforgia Nicola , Romeo Mario G. , Bollani Lina , Rinaldi Matteo , Gallo Elena , Quercia Michele , Maule Milena , Mostert Michael , Decembrino Lidia , Magaldi Rosario , Mosca Fabio , Vagnarelli Federica , Memo Luigi , Betta Pasqua M. , Stronati Mauro , Farina Daniele ,   on behalf of the Italian Task Force for the Study and Prevention of Neonatal Fungal Infections–the Italian Society of Neonatology
Published: December 2011

Background:
Lactoferrin is a mammalian milk glycoprotein involved in innate immunity. Recent data show that bovine lactoferrin (bLF) prevents late-onset sepsis in preterm very low birth weight (VLBW) neonates.

Methods:
This is a secondary analysis of data from a multicenter randomized controlled trial where preterm VLBW neonates randomly received bLF (100 mg/day; group A1), bLF + Lactobacillus rhamnosus GG (106 colony-forming units per day; group A2), or placebo (group B) for 6 weeks. Here we analyze the incidence rates of fungal colonization, invasive fungal infection (IFI), and rate of progression from colonization to infection in all groups.

Results:
This study included 472 neonates whose clinical, nutritional, and demographical characteristics were similar. Overall, the incidence of fungal colonization was comparable (17.6%, 16.6%, and 18.5% in A1, A2, and B, respectively; P = .89 [A1] and .77 [A2]). In contrast, IFIs were significantly decreased in A1 and A2 (0.7% and 2.0%, respectively) compared with B (7.7%; P = .002 [A1] and .02 [A2]), and this was significantly true both in &lt;1000 g (0.9% [A1] and 5.6% [A2], vs 15.0%) and in 1001 to 1500 g infants (0% and 0% vs 3.7%). The progression rate colonization-infection was significantly lower in the bLF groups: 3.7% (A1) and 12% (A2), vs 41.9%; P &lt; .001 (A1) and P = .02 (A2). No IFI-attributable deaths occurred in the treatment groups, versus 2 in placebo. No adverse effects or intolerances occurred.

Conclusions:
Prophylactic oral administration of bLF reduces the incidence of IFI in preterm VLBW neonates. No effect is seen on colonization. The protective effect on IFI is likely due to limitation of ability of fungal colonies to progress toward invasion and systemic disease in colonized infants.
Synthesis of fluorescent long-chain thiols/disulfides as building-blocks for self-assembled monolayers preparation
Authors: Jadhav Sushilkumar 
Published: December 2011

Abstract
New symmetrical disulfides together with the corresponding thiols bearing fluorescent end-groups have been synthesized as building-blocks for self-assembled monolayers (SAMs). The synthesis has been accomplished starting from aromatic nitrogen heterocycles in three steps. The conversion of the tosylated intermediate into the final disulfide is accomplished by use of sodium hydrogen sulfide (NaSH). Both products (thiols and disulfides) were isolated and characterized.
The effect of manganese on the structural and surface properties of nanocrystalline cobalt catalyst for ammonia synthesis
Authors: Lendzion-Bieluń Zofia 
Published: December 2011

Abstract
Based on the active surface model of the iron catalyst for ammonia synthesis, the assumptions which led to obtaining the cobalt catalyst for ammonia synthesis were described. The incorporation into the system small amounts of manganese, an element which binds oxygen stronger than cobalt, has influence the development of the catalyst’s specific surface area. The activity of manganese modified catalysts is higher than that of cobalt catalyst without manganese addition. The obtained catalysts were characterized with the following methods: ICP-OES, XRD, BET
Cinquante ans de coopération française avec l'Afrique subsaharienne
Authors: Jacquemot Pierre 
Published: December 2011

Résumé La vocation africaine de la coopération française n’a jamais été sérieusement mise en cause en cinquante ans d’histoire. Elle en a été l’un de ses fondements. En revanche, la singularité de sa démarche originelle, appuyée sur une doctrine du développement qui en faisait sa force et lui donnait son identité, s’est progressivement estompée : d’abord, avec l’alignement sur les thèses dominantes au plan international, puis avec les réformes des quinze dernières années. Elles ont modifié en profondeur le projet initial des développeurs, plus soucieuses de satisfaire ses contraintes d’organisation que de répondre aux attentes des bénéficiaires de l’aide. De cette aventure, autant politique qu’humaine, il reste un formidable héritage de savoir-faire façonnés dans une pratique engagée.
La production vidéo nigériane
Authors: Barrot Pierre 
Published: December 2011

Résumé Avec une production de fictions vidéo foisonnante et unique en son genre, le Nigeria a su conquérir un immense public populaire dans toute l’Afrique subsaharienne. Mais les films de « Nollywood » sont distribués dans des réseaux qui relèvent le plus souvent du secteur dit « informel ». Leurs budgets de production dérisoires aboutissent la plupart du temps à des niveaux de qualité technique et artistique très en dessous des normes internationales. Ils sont donc absents des festivals et cantonnés au petit écran. L’apparition récente d’un réseau de multiplexes au Nigeria pourrait changer la donne car certains producteurs ont commencé à produire, non sans succès, pour le grand écran.
Quand mondialisation rime avec prédation
Authors: Minani Rigobert , Merckaert Jean 
Published: December 2011

Résumé Entretien – Si un pays connaît la violence du capitalisme prédateur, c’est bien la République démocratique du Congo, où la bataille pour le pouvoir et pour le contrôle des immenses richesses du sous-sol ont fait plus de quatre millions de morts en quinze ans. Face à cette situation, la société civile lutte avec ses armes : le droit, la formation, les réseaux internationaux de solidarité, le courage
Vers une société d'abondance frugale. Contresens et controverses sur la décroissance
Authors: Renouard Camille 
Published: December 2011

Resumé Serge Latouche, Vers une société d’abondance frugale. Contresens et controverses sur la décroissance , Fayard / Mille et une nuits, 2011, 208 p., 4,50 €
Les contraintes de travail et les stratégies de régulation émotionnelle en centre de relation clientèle
Authors: Ribert-Van De Weerdt Corinne 
Published: December 2011

Résumé À l’heure où les risques psychosociaux sont préoccupants dans le monde du travail, les émotions sont de plus en plus examinées et étudiées. Elles sont en effet reconnues comme des agents régulateurs de situations difficiles ou contraignantes. L’étude de la composante émotionnelle du travail permet de mieux comprendre l’activité, ses enjeux, ses effets. Cet article présente une intervention menée en entreprise, portant sur l’analyse des émotions en lien avec l’activité et la santé, chez des conseillers clientèle de centres d’appels. Il décrit comment les émotions sont exprimées, affichées, et dissimulées par les salariés, ainsi que le « travail émotionnel » que les employés réalisent quotidiennement et ses conséquences sur la santé. Il montre quelles sont les contraintes de travail les plus difficiles et les plus pénibles pour les salariés, et les stratégies utilisées pour y faire face. Les risques psychosociaux sont particulièrement examinés. L’exposé des situations les plus compliquées à gérer amène à poser la question de leur impact en termes de stress. Les solutions de prévention mises en place sont discutées, au même titre que le plan d’accompagnement qui a été suivi dans l’entreprise.
Le métier comme instrument de protection contre les risques psychosociaux au travail : le cas d'ingénieurs managers de proximité
Authors: Miossec Yvon , Clot Yves 
Published: December 2011

Résumé Dans cet article, nous présentons la manière dont la clinique de l’activité aborde la question des risques psychosociaux. Après avoir relevé quelques limites dans l’approche de l’épidémiologie, nous présentons notre manière d’entrer dans cette question en posant le problème du métier. Le métier, c’est le rapport inachevé entre les dimensions psychologiques et sociales du travail. Nous analysons l’usage que des professionnels font d’une intervention réalisée à la demande du service de santé au travail d’une grande entreprise. Leur permet-elle d’établir de nouveaux rapports entre les instances du métier ? L’analyse des dialogues enregistrés pendant l’intervention met en lumière deux modes de fonctionnement du métier. Nous expliquons avec ce modèle du métier en quoi ces fonctionnements sont favorables ou défavorables à la santé au travail.
L' intervention ergonomique sur les risques psychosociaux dans les organisations : enjeux théoriques et méthodologiques
Authors: Petit Johann , Dugué Bernard , Daniellou François 
Published: December 2011

Résumé Une action sur les rps nécessite, si elle se veut efficace, de permettre une mise en débat sur le fonctionnement organisationnel de l’entreprise, la répartition des lieux et des circuits de décision. Cet article a pour objectif de présenter les enjeux théoriques et méthodologiques que cela représente pour l’action ergonomique sur les rps . Dans un premier temps, nous proposons un cadre théorique qui nous permet de montrer que les ergonomes ont un rôle à jouer sur les rps . Pour cela, il est question de pouvoir mettre en lien la souffrance exprimée par les opérateurs avec les difficultés de production émanant de défaillances organisationnelles, et plus particulièrement les difficultés rencontrées par les salariés pour « bien faire leur travail ». Nous présentons alors un exemple d’intervention dans une entreprise de service pour étayer nos propos. Pour terminer, nous nous appuyons sur le concept de subsidiarité comme guide à la réflexion sur la conception organisationnelle pour les ergonomes.