bluuebunny/crossref_metadata_2025_split huggingface dataset:
Topical Solution for Retinal Delivery: Bevacizumab and Ranibizumab Eye Drops in Anti-Aggregation Formula (AAF) in Rabbits
Authors: Giannos Steven A. , Kraft Edward R. , Luisi Jonathan D. , Schmitz-Brown Mary E. , Reffatto Valentina , Merkley Kevin H. , Gupta Praveena K. 
Published: June 2024

Abstract
Purpose
Wet age-related macular degeneration (AMD) is a blinding retinal disease. Monthly intravitreal anti-VEGF antibody injections of bevacizumab (off-label) and ranibizumab (FDA approved) are the standard of care. Antibody aggregation may interfere with ocular absorption/distribution. This study assessed topical delivery of dilute antibodies to the posterior segment of rabbit eyes using a novel anti-aggregation formula (AAF).

Methods
Bevacizumab, or biosimilar ranibizumab was diluted to 5 mg/ml in AAF. All rabbits were dosed twice daily. Substudy 1 rabbits (bevacizumab, 100 µl eye drops): Group 1 (bevacizumab/AAF, n = 6); Group 2 (bevacizumab/PBS, n = 7) and Vehicle control (AAF, n = 1). Substudy 2 rabbits (ranibizumab biosimilar/AAF, 50 µl eye drops): (ranibizumab biosimilar/AAF, n = 8). At 14.5 days, serum was drawn from rabbits. Aqueous, vitreous and retina samples were recovered from eyes and placed into AAF aliquots. Tissue analyzed using AAF as diluent.

Results
Bevacizumab in AAF permeated/accumulated in rabbit aqueous, vitreous and retina 10 times more, than when diluted in PBS. AAF/0.1% hyaluronic acid eye drops, dosed twice daily, provided mean tissue concentrations (ng/g) in retina (29.50), aqueous (12.34), vitreous (3.46), and serum (0.28 ng/ml). Additionally, the highest concentration (ng/g) of ranibizumab biosimilar was present in the retina (18.0), followed by aqueous (7.82) and vitreous (1.47). Serum concentration was negligible (< 0.04 ng/ml). No irritation was observed throughout the studies.

Conclusions
Bevacizumab and ranibizumab, in an AAF diluent eye drop, can be delivered to the retina, by the twice daily dosing of a low concentration mAb formulation. This may prove to be an adjunct to intravitreal injections.
On the desire to make a difference
Authors: Greaves Hilary , Thomas Teruji , Mogensen Andreas , MacAskill William 
Published: June 2024

AbstractTrue benevolence is, most fundamentally, a desire that the world be better. It is natural and common, however, to frame thinking about benevolence indirectly, in terms of a desire to make a difference to how good the world is. This would be an innocuous shift if desires to make a difference were extensionally equivalent to desires that the world be better. This paper shows that at least on some common ways of making a “desire to make a difference” precise, this extensional equivalence fails. Where it fails, “difference-making preferences” run counter to the ideals of benevolence. In particular, in the context of decision making under uncertainty, coupling a “difference-making” framing in a natural way with risk aversion leads to preferences that violate stochastic dominance, and that lead to a strong form of collective defeat, from the point of view of betterness. Difference-making framings and true benevolence are not strictly mutually inconsistent, but agents seeking to implement true benevolence must take care to avoid the various pitfalls that we outline.
Interviews with farmers from the US corn belt highlight opportunity for improved decision support systems and continued structural barriers to farmland diversification
Authors: Nowatzke Matthew , Gao Lijing , Dorneich Michael C. , Heaton Emily A. , VanLoocke Andy 
Published: June 2024

AbstractDiversifying high-input, monocropped landscapes like the US Corn Belt would provide both economic and ecosystem service benefits to the agricultural landscape. Decision support systems (DSS) and digital agriculture could help farmers decide if diversification is suitable for their operation. However, adoption of DSS by farmers remains low, likely due to lack of farmer engagement before and during the DSS development process. This study aimed to better understand the tasks, tools, and people involved in implementing farmland diversification with the goal to inform design of agricultural DSS. Semi-structured interviews were conducted with 11 farmers who had diversified their corn/soybean cropland with government-supported conservation programs (e.g., CRP, wetlands) and alternative crops (e.g., small grains, pasture) in the past four years. Interview data was transcribed and then analyzed using affinity diagramming. Results show farmers needed DSS to layer multiple sources of data and observations over several years to identify field productivity trends and drivers; spatial orientation of practices to fit management and field constraints; matching operation goals to alternative practices; financial planning and market exploration; and information on promising emerging practices like subsidized pollinator habitat. However, the interviews also highlighted structural barriers to diversification that DSS cannot or can only partially address. These included social pressures; market access; crop insurance policy; and quality of relationships with governmental agencies. Results indicate better DSS design can empower individual farmers to diversify cropland, but structural interventions will be needed to successfully diversify the agricultural landscape and support economic and ecosystem health.
German adult population norm values of the short Warwick Edinburgh mental well-being scale (SWEMWBS)
Authors: Peitz Diana , Hoelling Heike , Born Sabine , Rosario Angelika Schaffrath , Cohrdes Caroline 
Published: June 2024

Abstract
Purpose
The Warwick-Edinburgh Mental Well-Being Scale represents an internationally established inventory to assess population mental well-being. Particularly the short form (SWEMWBS) is recommended for use in Mental Health Surveillance. In the present study, we present normative data of the SWEMWBS for the German adult population.

Methods
Data from the telephone survey German Health Update (GEDA) in 2022 representative of the German adult population (48.9% women, 18–98 years) was processed to estimate SWEMWBS percentile norm values, T-values, z-values and internationally comparable logit-transformed raw scores for the total sample (N = 5,606) as well as stratified by sex, age group and sex with age group combinations.

Results
The average mental well-being was comparable to that of other European countries at M = 27.3 (SD = 4.0; logit-transformed: M = 24.79, SD = 3.73). To provide a benchmark, the cut off for low well-being was set at the 15th percentile (raw score: 23; logit-transformed: 20.73), for high well-being at the 85th percentile (raw score: 32; logit-transformed: 29.31).

Conclusion
The present study provides SWEMWBS norm values for the German adult population. The normative data can be used for national and international comparisons on a population level to initiate, plan and evaluate mental well-being promotion and prevention measures.
Teacher evaluations of interethnic bullying of an Arab student: The role of perceiving refugees as a threat or benefit
Authors: Kollerová Lenka , Soukup Petr , Strohmeier Dagmar , Caravita Simona C. S. , Killen Melanie 
Published: June 2024

AbstractInterethnic bullying that targets ethnic minority students has serious consequences for the lives of victimized students. Teachers’ evaluations of the bullying are critical because teacher intervention can stop bullying and improve the adjustment of victimized students. Because the literature has documented partially overlapping biases against people of Arab ethnicity and people with refugee backgrounds, this study investigated whether teachers’ attitudes toward refugees play a role in their evaluations of the interethnic bullying of an Arab student. Teachers (n = 373; 77% female) who participated in the study filled the Threats–Benefits Inventory (TBI) that measured two types of attitudes toward refugees (perceiving refugees as a threat and perceiving refugees as a benefit) and evaluated a hypothetical vignette of interethnic bullying targeted at an Arab student. SEM analysis, controlling for gender, age, and contact with refugees, indicated that teachers’ attitudes toward refugees were not associated with their perceptions of the interethnic bullying as wrong or with their willingness to intervene. However, viewing refugees as a source of high threat or low benefit was consistently associated with lower recognition of the negative outcomes of the interethnic bullying. Moreover, a greater willingness to intervene positively associated with female gender and increasing age. The study suggests that teachers’ attitudes toward refugees may contribute to underestimating negative outcomes of interethnic bullying among students. To foster appropriate evaluations of interethnic bullying, teacher education should aim to promote understanding of different marginalized groups and to reduce biases against people with refugee backgrounds.
A Note on Real Line Bundles with Connection and Real Smooth Deligne Cohomology
Authors: Flydal Peter Marius , Quick Gereon , Svanes Eirik Eik 
Published: June 2024

AbstractWe define a Real version of smooth Deligne cohomology for manifolds with involution which interpolates between equivariant sheaf cohomology and smooth imaginary-valued forms. Our main result is a classification of Real line bundles with Real connection on manifolds with involution.
Prognosis of non-vital incisors after apexification using bioceramics: a retrospective study
Authors: Anjum F. S. , Brusevold I. J. , Wigen T. I. 
Published: June 2024

Abstract
Purpose
To evaluate the outcome of apexification using bioceramics in immature permanent teeth, and to study the factors influencing treatment outcome and frequency of spontaneous cervical root fractures.

Methods
Forty-six children with 51 non-vital permanent incisors treated with a bioceramic apical plug were included. Mean age at pulp necrosis was 9.8 (SD 2.2) years and mean follow-up time was 3.3 (SD 2.4) years. Data were extracted from dental records and included stage of root development, presence of external root resorptions, clinical signs of infection, size of periapical lesion, type and placement of bioceramic plug, and spontaneous root fracture. Treatment outcome was assessed using periapical index (PAI-score) and presence of clinical symptoms. The statistical analyses were conducted using IBM SPSS Statistics for Windows, version 28 (IBM Corp., Armonk, N.Y., USA). Data were cross-tabulated and tested with chi-square statistic.

Results
Biodentine™ was used as apical plug in 78.4% of the teeth and MTA in 21.6%. Complete healing or signs of healing was reported in 86.3% of the teeth, whilst seven teeth (13.7%) were non-healed. All non-healed teeth had preoperative clinical signs of infection. No difference was found in stage of root development, presence of root resorption, and type and placement of bioceramic plug in healed and non-healed teeth (p > 0.05). Five teeth (9.8%) exhibited root fracture 1–6 years after treatment and all had very immature root development. Type of bioceramic or external root resorption was not associated with spontaneous root fracture.

Conclusion
Apexification using bioceramics showed favourable prognosis in immature permanent teeth. Very immature teeth were at risk of root fracture after apexification with bioceramics.
Endocrinology application of molecular imaging: current role of PET/CT
Authors: Calderoni L. , Giovanella L. , Fanti S. 
Published: June 2024

Abstract
Background
In recent years, nuclear medicine imaging methods have proven to be of paramount importance in a wide variety of diseases, particularly in oncology, where they are crucial for assessing the extent of disease when conventional methods fall short. Moreover, nuclear imaging modalities are able to better characterize lesions using target agents related to specific pathways (e.g. glucose metabolism, cellular proliferation, amino acid transport, lipid metabolism, specific receptor ligands). The clinical presentation of endocrine diseases encompasses a broad spectrum of sign and symptoms. Moreover, endocrine tumors show varying degrees of aggressiveness from well differentiated and indolent to highly aggressive cancers, respectively.

Rationale
With the application of new medicinal radio-compounds and increasingly advanced tomographic imaging technology, the utility of Positron Emission Tomography/Computed Tomography (PET/CT) in the field of endocrine diseases is expanding.

Aim
This review aims to analyze and summarize the primary indications of PET/CT, providing a practical approach for clinicians. A comprehensive literature search on PubMed was conducted to provide an updated overview of the available evidence regarding the use of PET/CT in endocrinology. Within this review, we will discuss the applications of PET/CT, compare different radiopharmaceuticals and highlight the uptake mechanism, excluding neuroendocrine carcinomas from discussion.

Conclusions
PET/CT is a valuable tool in diagnosing and managing endocrine disorders due to its capacity to furnish both functional and anatomical information, facilitate early lesion detection, guide treatment decisions, and monitor treatment response. Its non-invasive nature and precision make it an integral component of modern endocrine healthcare. This review aims to provide physicians with a clear perspective on the role of PET/CT imaging, discussing its emerging opportunities and appropriateness of use in endocrinological diseases.
Investigation of the microfracture and damage characteristics of dam during impoundment at Sanhekou hydropower station
Authors: Ma Ke , Li Yu , Liao Zhiyi , Wang Zuorong , Jiang ZhengChun , Wang Rulin 
Published: June 2024

AbstractDam stability is one of the most important issues in hydraulic engineering. Microfractures and damage commonly occur during impoundment, which might lead to serious dam problems. In this study, based on the engineering background of the Sanhekou hydropower station, microseismic monitoring and numerical simulation were employed to systematically investigate the microfracture and damage characteristics of the dam body. First, the microseismic monitoring system was established to capture the microfractures inside the dam. The results indicated that the rise in water level elevation has a significant effect on the microfracture and damage characteristics of the dam body, especially during the early stage of impoundment. This can be reflected by the variation in the derived source parameters, i.e., the b value, daily energy release, daily apparent stress and daily apparent volume. In addition, the failure mode of the microfractures could be determined by using the ES/EP value of microseismic events and the moment tensor inversion method. The cracking orientation of the failure surfaces could also be determined by the moment tensor inversion method. Subsequently, numerical simulation was conducted where the initial damage of the dam was considered by integrating the microseismic monitoring data. The simulation results suggested that dam deformation under impoundment considering microseismic feedback agrees well with the real field measured results. The stress level of the dam toe was larger than that of the dam heel, and both the dam toe and dam heel were under compression before impoundment. However, with increasing water level elevation, the stress status of the dam heel area changes from compression to tension. The findings in this study will provide a better understanding of the damage and failure mechanism of dams during impoundment, which might be helpful for the design and support of dams in hydropower stations.
Terminalia catappa leaf extract as a bio-reducing agent to synthesize Cu2O nanoparticles for methylene blue photodegradation
Authors: Nguyen Thi Hoai Phuong , Nguyen Thi Phuong , Nguyen Thi Anh Thu , Nguyen Tien Dung , Chang S. Woong , Nguyen D. Duc , La D. Duong 
Published: June 2024

AbstractThe large tree species Terminalia catappa is a member of the Combretaceae family and is mainly found in tropical climates. They are commonly cultivated for shade because they have huge, dense foliage. Numerous polyphenols, including flavonoids, tannins, saponins, and phytosterols, are present in the leaves. In this study, the green chemical method was used to extract polyphenols from dried green almond leaves. They were employed in the synthesis of Cu2O nanoparticles as a reducing agent. FTIR and UV–Vis were used to describe the leaf extract of Terminalia catappa after the chlorophyll was removed. Copper salt was used to create Cu2O nanoparticles via a reduction process. The extract's potential for photocatalytic dye degradation has also been explored. The obtained Cu2O had a spherical shape with dimensions of 50–100 nm, and its band gap energy reached 1.945 eV to remove methylene blue from aqueous media under visible light irradiation conditions. At an initial MB concentration of 10 ppm, the decomposition efficiency reached 71.99% after only 2 h of exposure to simulated sunlight. The decomposition process occurred according to a pseudo-first-order kinetic model with a rate constant of 0.0084 min−1.
Were post-colonial cities US imperial cities?
Authors: Schayegh Cyrus 
Published: June 2024

Abstract
This exploratory text proposes a US imperial ‘research perspective’ on post-war post-colonial cities – cities that the United States did not colonially occupy, i.e. not cities like Manila, 1898–1946. US imperial actors and interests helped shape such cities, and in turn were shaped by their people and structures. Importantly, the US case seems to strengthen the general recent view, also regarding formal empires, that it makes little sense to posit the existence of an imperial city type, and more sense to use ‘the imperial urban’ as a research perspective.
Simulation of Regional Secondary Organic Aerosol Formation From Monocyclic Aromatic Hydrocarbons Using a Near‐Explicit Chemical Mechanism Constrained by Chamber Experiments
Authors: Lu Hutao , Huang Qi , Li Jingyi , Ying Qi , Wang Hongli , Guo Song , Qin Momei , Hu Jianlin 
Published: June 2024

AbstractThe formation of secondary organic aerosol (SOA) is inextricably linked to the photo‐oxidation of aromatic hydrocarbons. However, models still exhibit biases in representing SOA mass and chemical composition. We implemented a box model coupled with a near‐explicit photochemical mechanism, the Master Chemical Mechanism (MCMv3.3.1), to simulate a series of chamber studies and assess model biases in simulating SOA from representative monocyclic aromatic hydrocarbons, that is, toluene and three xylene isomers (TX SOA). The box model underpredicted SOA yields of toluene and xylenes by 4.7%–100%, which could be improved by adjusting the saturation vapor pressure (SVP) of their oxidation products. After updating the SVP values, the mass concentration of TX SOA in the Yangtze River Delta region during summer doubled, and there was also an approximate 3% enhancement in the total SOA. Compared to a lumped mechanism used for simulating TX SOA, MCM predicted comparable mass concentrations but exhibited different volatility distributions and oxidation states.
Reconstruction of Cenozoic δ11Bsw Using a Gaussian Process
Authors: Whiteford Ross , Heaton Timothy J. , Henehan Michael J. , Anagnostou Eleni , Jurikova Hana , Foster Gavin L. , Rae James W. B. 
Published: June 2024

AbstractThe boron isotope ratio of seawater (δ11Bsw) is a parameter which must be known to reconstruct palaeo pH and CO2 from boron isotope measurements of marine carbonates. Beyond a few million years ago, δ11Bsw is likely to have been different to modern. Palaeo δ11Bsw can be estimated by simultaneously constraining the vertical gradients in foraminiferal δ11B (Δδ11B) and pH (ΔpH). A number of subtly different techniques have been used to estimate ΔpH in the past, all broadly based on assumptions about vertical gradients in oxygen, and/or carbon, or other carbonate system constraints. In this work we pull together existing data from previous studies, alongside a constraint on the rate of change of δ11Bsw from modeling. We combine this information in an overarching statistical framework called a Gaussian Process. The Gaussian Process technique allows us to bring together data and constraints on the rate of change in δ11Bsw to generate random plausible evolutions of δ11Bsw. We reconstruct δ11Bsw, and by extension palaeo pH, across the last 65Myr using this novel methodology. Reconstructed δ11Bsw is compared to other seawater isotope ratios, namely , , and δ7Li, which we also reconstruct with Gaussian Processes. Our method provides a template for incorporation of future δ11Bsw constraints, and a mechanism for propagation of uncertainty in δ11Bsw into future studies.
Structural Inheritance in the Eastern Cordillera, NW Argentina: Low‐Temperature Thermochronology of the Cianzo Basin
Authors: van Kooten Willemijn S. M. T. , Vallati Michele , Sobel Edward R. , del Papa Cecilia E. , Payrola Patricio , Starck Daniel , Bande Alejandro , Wayar Córdoba Maria F. , Lapiana Ayelén T. , Glodny Johannes 
Published: June 2024

AbstractThe present‐day deformation style of the Eastern Cordillera in NW Argentina is strongly influenced by the inversion of pre‐existing Paleozoic and Mesozoic structures. In particular, the extensional faults and lithological contrasts resulting from the Cretaceous–Paleogene Salta Rift phase form heterogeneities that were preferentially reactivated during the Andean orogeny. Constraining the timing and characteristics of reactivation is a key to understanding the interplay between tectonics and inherited crustal anisotropies. In this study, we combine structural and sedimentological field data with a low‐temperature thermochronology data set from the area surrounding the fault‐bounded Cianzo basin. The southeastern boundary is formed by the inverted Hornocal fault, which was the basin‐bounding normal fault of the Lomas de Olmedo sub‐basin (Salta Rift basin). Lacustrine deposits of the Yacoraite Formation overspill on the footwall of this fault and mark tectonic quiescence during the post‐rift phase of the Salta Rift. Apatite (U‐Th‐Sm)/He and fission track ages in the Hornocal fault hanging wall show an onset of rapid cooling interpreted to be concomitant with fault inversion between the latest Oligocene and middle Miocene (∼24–15 Ma). Low‐temperature thermochronology data also constrain the timing of major folding in the eastern limb of the Cianzo syncline to pre‐10 Ma, whereas the western limb started tilting post‐10 Ma. Characterization of exhumation patterns related to fault activity surrounding the Cianzo basin emphasizes the influence of the pre‐existing structural framework on deformation in fold‐and‐thrust belts.