bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diastolic function parameters in normotensive offspring of hypertensive Nigerians: Comparison with age-matched control
Authors: Iruolagbe Christopher Ojemiega , Ogbemudia Ehimwema Judith , Evbayekha Endurance Osas , Shielu Muhammed Lawal , Okokhere Peter Odion , Obasohan Austine O. 
Published: May 2024

Abstract

Background:
Systemic hypertension is associated with left ventricular systolic and diastolic dysfunction (LVD). Left ventricular diastolic dysfunction (LVDD) is present in over 25% of adults over 40 years of age and may precede the onset of systemic hypertension. Genetic predisposition may be the reason why some normotensive (NT) individuals develop systemic hypertension despite modest lifestyle modification and others do not.

Aim:
This study aimed to compare diastolic function parameters in NT offspring of Nigerians with systemic hypertension with those of NT offspring of NT individuals.

Materials and Methods:
A total of 45 NT offspring of parents with systemic hypertension (ocular hypertension [OHT]) were selected with 45 NT ONT parents, matched for age and sex. All subjects had echocardiography (echo) and electrocardiography (ECG) done. The presence and pattern of LVDD in all subjects were analyzed statistically. Analysis of data was done using the Statistical Package for the Social Sciences (SPSS) version 19.

Results:
This study observed a statistically significant difference in some LVDD echo parameters between OHT subjects and ONT controls. The left atrial volume (LAV: t = 2.229, P = 0.028), LAV index (LAVI: t = 2.578, P = 0.012), isovolumic relaxation time (IVRT: t = 3.630, P < 0.0001), and difference in atrial reversal and A-wave duration (Ar-A: t = 2.649, P = 0.01) had a statistically significant difference in their mean values between OHT subjects and ONT controls. The prevalence of LVDD in this study was 17.78%. Impaired relaxation (Grade I LVDD) pattern had the highest frequency compared to pseudonormal (Grade II LVDD) pattern (26.67% vs. 4.44%) in OHT subjects. There was no subject in the study population who had restrictive (Grade III or IV LVDD) pattern. It was observed that three sets of LVDD parameters were present in all subjects with LVDD and they were as follows: (1) IVRT + E/A + DT, (2) IVRT + E/A + DT + E/e’, and (3) IVRT + E/A + DT + E/e’ + S/D + Ar-A. The prevalence of abnormal LV geometric pattern was 42.2% (CR: 20%, CH: 13.3%, and EH: 8.9%) in OHT subjects, and this was about two and half times more than the prevalence in ONT controls. Furthermore, the prevalence of LV hypertrophy (CH and EH) in OHT subjects was 22.2%, while it was 14.4% in all subjects in this study. There was a significant correlation between DBP and all echocardiographic LVDD parameters in OHT subjects except A-wave, E/e’ ratio, and systolic fraction (S/D ratio).

Conclusions:
LVDD and abnormalities are present in NT offspring of systemic hypertensive individuals. These findings suggest that LVDD precedes the development of systemic hypertension.
Telemedicine for Facial Plastic Surgery Patients: Pros and Cons from the Patient’s Perspective
Authors: Alshehri Ali Abdullah 
Published: May 2024

Abstract

Aims and Background:
Telemedicine is an exciting development that enables medical professionals and patients to communicate remotely. Telemedicine has been shown to enhance accessibility, efficiency, and cost savings. However, it also has disadvantages, including challenges in using online platforms and unease during physical examinations. The objective of this research is to evaluate telemedicine utilization as perceived by patients undergoing facial plastic surgery.

Materials and Methods:
A questionnaire-based study was conducted among 100 patients who experienced teleconsultation at Najran University Hospital.

Results:
Most of the patients (74%) were satisfied with their experience, and a large number (93%) indicated that teleconsultation saved them time and money.

Conclusion:
Most patients found telemedicine to be beneficial. However, many still consider it less reliable than in-person visits, with 78% indicating they were not willing to use teleconsultation in the future.
Mortalidad por tuberculosis en España, 2008-2021
Authors: Roncal Redin Miriam , Gomez Barroso Diana , Herrador Zaida 
Published: May 2024

Introducción: La tuberculosis (TB) presenta una elevada carga de morbimortalidad, siendo la principal causa de mortalidad por agente infeccioso en el mundo, sólo superada recientemente por la COVID-19. El objetivo de este estudio fue analizar la evolución espacio temporal de la mortalidad por TB en España entre 2008-2021.
Método: Análisis epidemiológico descriptivo de los casos de defunción por TB registrados en el Instituto Nacional de Estadística (INE) durante 2008-2021. Las variables analizadas fueron sexo, edad, provincia y año de defunción. Se realizó análisis descriptivo de las variables principales y un análisis espacio temporal de las tasas de mortalidad (TM) y las razones de mortalidad estandarizadas (RME).
Resultados: Del 2008 al 2021, se notificaron 3.876 decesos por TB, con una TM media de 0,6 por 100.000 habitantes. Más del 60% de las defunciones fueron en mayores de 75 años. Se observó una tendencia decreciente en las TM con un porcentaje de cambio medio anual (PCMA) de -5,2%. Se observó un mayor número de muertes en hombres (64,1%), así como una mayor disminución en sus TM (PACMA -5,5% vs -4,5% en mujeres). Todas las provincias descendieron sus TM excepto Palencia, Cantabria y Huesca. Las RME se distribuyeron de forma diferente según las provincias y según el sexo, con mayores RME en hombres.
Conclusiones: La TM por TB en España ha seguido una tendencia descendente desde 2008, aunque con un patrón y evolución desigual por sexo y provincia. Es necesario realizar más estudios que permitan explicar las diferencias observadas.
Hubungan Pengetahuan tentang Jajan Sehat dengan Status Gizi Anak di SDN Mancar 01 Peterongan Jombang
Authors: Puspita Sylvie , Aziz Aditya Nuraminudin Aziz , Temorubun Lusiana Bernadeta 
Published: May 2024

Status gizi merupakan salah satu indikator yang digunakan untuk mengukur keadaan tubuh akibat mengonsumsi makanan dan penggunaan zat-zat gizi. Status gizi dibedakan menjadi 4 kategori, yaitu gizi kurang, gizi baik dan gizi lebih dan obesitas. Konsumsi seseorang berpengaruh pada status gizi seseorang dimana status gizi baik atau status gizi optimal terjadi apabila tubuh memperoleh cukup zat gizi yang digunakan secara efisien, sehingga kemungkinan pertumbuhan fisik, perkembangan otak, kemampuan kerja dan kesehatan secara umum berada pada tingkat yang optimal. Tujuan Penelitian ini adalah Untuk Mengetahui Hubungan Pengetahuan Tentang Jajan Sehat Dengan Status Gizi Anak Di Sekolah Di SDN Mancar 01 Peterongan Jombang. Desain penelitian ini menggunakan analitik korelasi dengan pendekatan cross sectional. Dalam penelitian ini didapatkan populasi 70 siswa/siswi kelas IV,VI dan VI SDN Mancar 01 Peterongan Jombang dengan jumlah sampel 60 responden. Dengan menggunakan teknik purposive sampling. Alat pengumpulan data berupa lembar kuesioner serta analisis data menggunakan uji spearman rho. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki pengetahuan baik sebanyak 37 responden (61,7%) dan hampir seluruhnya responden memiliki status gizi cukup sebanyak 57 responden (95,0%). Berdasarkan hasil uji spearman rho didapatkan nilai 0,00 < a (0,05), H1 diterima yang berarti ada Hubungan Pengetahuan Tentang Jajan Sehat Dengan Status Gizi Anak Di Sekolah Di SDN Mancar 01 Peterongan Jombang. Siswa/siswi diharapkan memiliki pengetahuan atau informasi yang baik untuk mencegah status gizi buruk dan lebih memperhatikan dalam memilih jajan sehat/makanan ringan untuk dapat memenuhi kebutuhan gizinya.
Improving the quality of mustard seeds during pre-sowing preparation
Authors: Mykolaiko I. I. 
Published: May 2024

Purpose. With the introduction of modern technologies for growing seeds of agricultural crops, the requirements for the quality of seed material are increasing, without which it is impossible to use advanced technologies of growing. Therefore, the development and improvement of ways to improve the quality of seeds during their pre-sowing preparation is relevant for all crops, since modern technologies provide for sowing at the final density. Therefore, the purpose of the research is to determine the efficiency of sorting mustard seeds by specific gravity depending on varietal characteristics. Methods. Laboratory, measuring-weighing, correlation-regression and mathematical-statistical. The results. The article presents the results of a study on the efficiency of seed sorting by specific gravity on a pneumatic table with the aim of increasing its similarity of different varieties of mustard, with unchanged longitudinal and transverse angles of inclination of the working surface of the pneumatic table and a frequency of oscillations of the working surface of 486 oscillations per minute ensured a reliable increase in the quality of seeds – mass 1000 seeds, germination energy and germination compared to the control. Germination energy and germination of the prepared seeds increased by 4 and 3 %, respectively (NIP0.05 = 2.7 for germination energy and 1.7 % for germination), compared to the control, while seeds with a germination energy of 91 % entered the intermediate fraction (position 3) and 79% (position 4). Seeds from position 3 should be re-sent to sorting, and seeds from position 4 should be sent to waste. A similar increase in the mass of 1000 seeds was observed, which increased, the seeds prepared for sowing, and the mass of 1000 seeds fell into the intermediate fraction, which was smaller than in the control. Correlation-regression analysis revealed a strong direct correlation between the weight of 1000 seeds and germination energy and between the weight of 1000 seeds and similarity with a correlation coefficient of 0.93 and 0.89, respectively. Conclusions. In the sorting mode with small angles of inclination of the working surface of the pneumotable and 486 oscillations/minute on average for all grades with negligible deviation – 86.8% of seeds with the highest quality indicators were obtained. Varieties responded differently to seed sorting. The energy of germination and germination of the prepared seeds of most varieties was 98–99 %, and the Pidpecheretska and Oslava varieties were maximum and amounted to 100 %.
Стевія rebaudiana Bertoni. The composition and pharmacological action of stevia
Authors: Stefaniuk V. Y. , Losieva A. I. , Pavlichenko M. V. 
Published: May 2024

Formulation of the problem. The article describes the nutritional and medicinal value of stevia. Methods: curative-prophylactic, medical-biological, medicinal. The results. Stevia is used as a therapeutic and preventive agent for: diseases of the liver and biliary tract (dyskinesia, cholecystocholangitis, hepatitis); diseases of the pancreas (fermentopathy, pancreatitis); diabetes; atherosclerosis, hypertension of various genesis; gerontological diseases (menopausal period); gynecological diseases and diseases of the male genital area; diseases of the oral cavity (gingivitis, periodontitis, stomatitis, etc.); recovery after severe and long-term illnesses; treatment of alcoholism, drug addiction and smoking; obesity of alimentary origin; blood loss; respiratory diseases (SARS, bronchitis, bronchopneumonia). Medical and biological studies have shown that the use of stevia honey normalizes the work of enzyme systems of the body, leads to the normalization of sugar levels and a decrease in cholesterol levels in the blood, that is, to the restoration of carbohydrate, lipid, protein and water-salt exchanges. Substances found in stevia provide immunomodulatory, anti-stress, anti-anemic, hepatoprotective and anti-inflammatory effects; restore blood microcirculation, have a bacteriostatic, antiallergic, antisclerotic effect; exhibit highly active adsorption action; neutralize and remove toxins (including radionuclides); have an antitumor and energy-saving effect; stimulate the digestive and urinary organs; are a powerful antioxidant.
ANALYSIS OF FLOUTING MAXIM IN SCHIZOPHRENIC CHARACTER FOUND IN BEAUTIFUL MIND MOVIE
Authors: Hidayatulloh Aris , Ayiz Abdul 
Published: May 2024

Conversational implicature was proposed by Grice (1989) into four maxims. Those are: 1) quantity maxim, 2) quality maxim, 3) relation maxim, and 4) manner maxim. It is affects in the communication in society. It is also occurred in the communicative impairment. One of the phenomena is on the schizophrenia which affect on the deficit pragmatic and the ability to comprehend the implied meaning.
The data of this research is from the representative utterances from John Nash which deals with something the speaker believes. The reason in specify the data is due to the limitation of this research in order to get more details about the pattern of the implicature in the believe of schizophrenic character. The data is classified into the classification by Searle and Vanderveken which is concentrated in the representative speech act before analysing it in implicature. The theory by Grice about the four maxims is used in this research to know about the conversational implicature by the main character who is diagnosed with schizophrenia.
The results shows that most dominant flouting maxim is on the relation maxim. 13 chosen data which deals with the floating maxim shows the result as follows: 3 data in quantity maxim; 1 datum in quality maxim; 6 data in relation maxim; and 3 data in manner maxim. In flouted quantity maxim utterances do not deliver well in the conversation due to schizophrenia. It deals with the ability from speaker to have in line in the topic. The flouting maxim in quantity maxim and manner maxim has the same percentage. From flouting quantity maxim, Nash does over utterance in delivering the message so that the hearers do not understand what Nash mean. The flouted manner maxim indicates the inability of the speaker in delivering in a good manner and has a sufficient meaning in the utterance. While the fluted quality maxim does not affect to the conversation.
Antiphospholipid Syndrome and Lupus Anticoagulant:
Where do we stand today
?
Authors: Trivedi Shalini , Verma Sarika , Kaur Omkaar , Agarwal Sonal , Singhal Udita , Singh Mily Biswas 
Published: May 2024

Abstract
Lupus Anticoagulant (LAC) is a group of auto antiantibodies that interfere with phospholipid dependent tests like Activated Partial Thromboplastin time (APTT) and dilute Russell Viper venom time (dRVVT) on in vitro basis. LA, anti cardiolipin antibodies (aCL) IgG/IgM, and anti-β2 glycoprotein I antibodies [aβ2GPI]IgG/IgM are three diagnostic criteria for laboratory diagnosis of anti-phospholipid antibodies (aPL). The circulating aPLs in the clinical setting of hypercoagulability state or adverse pregnancy outcomes is termed as anti-phospholipid syndrome (APS).
The laboratory diagnosis of APS is complicated, it includes constellation of tests like solid phase immunoassays for measurement of aCL and a β 2GPI by and coagulation based assays for detection of LAC. LAC diagnosis is especially challenging in the setting of anti-coagulation therapy, numerous modifications to circumvent this interference have rendered success.
The Thrombin generation assays [TGA] for LAC detection and estimation of LAC pathogenicity are available but are yet to be accepted as routine laboratory tests. The medley of assays like Enzyme-linked immunosorbent and chemiluminescent assays are available for detection of aCL and aβ2GPI but due to the non-availability of universal calibrators and standards there is lack of harmonization between various solid phase assays.
In this article we intend to highlight new recommendations of laboratory diagnosis of LAC with special emphasis on diagnosis in the setting of pregnancy and anti-coagulation. For risk assessment in APS other non-criteria aPL like as anti-domain β2 glycoprotein I and anti-phosphatidyl serine/prothrombin antibodies are under evaluation.
There is an ongoing quest towards harmonization of detection of LAC, thus there has been succession of guidelines to meet the challenges and incorporate newly found knowledge every time, namely International Society for Thrombosis and Hematology- Scientific Standardization Committee (ISTH-SSC) guidelines, followed by British Committee for Standards in Hematology (BCSH), Clinical and Laboratory Standards Institute (CLSI) guidelines 2014 and finally guidelines/updates issued by ISTH- SSC in 2018.
Anesthesia Management of COVID-19 associated Rhino-Orbito-Cerebral Mucormycosis: A Prospective Observational Study
Authors: Sontakke Ashwini Y , Kulkarni Vaishnavi V , Nandanvankar Nitin N , Totawar Sachin 
Published: May 2024

Abstract

Background: Fungal infections (mucormycosis) have been reported as co-infection as well as opportunistic infection during and after COVID-19 (Coronavirus disease), involving the paranasal air sinuses with a high risk of morbidity and mortality. Considering the ongoing situation of COVID-19 associated with mucormycosis, we presented our experience of 110 patients being, or having previously been COVID -19 positive. Methods: This study included 110 patients in which surgical resection was done for Rhino-orbito-cerebral mucormycosis (ROCM) under general anesthesia and observed for 30 days postoperatively. Results: This study included 79 male patients with the majority of 51-60 years of age group (31.81%). Most common comorbidities observed in study were diabetes mellitus (77.27 %) followed by hypertension (39.09 %) & ischemic Heart Disease (9.09 %). Majority patients had received steroids (80 %) as a part of covid-19 treatment. All patients were receiving Amphotericin B at the time of surgery. On operative table extubation was possible in 80 % of the cases while others required average ICU stay (9.83 ± 7.33 days). Inotropic support was required in 20 % of patients. Majority patients were discharged successfully (85.45 %), while 10.91 % had mortality. On 30 days follow-up frontal Sinus Abscess (6.36 %) & maggots in maxilla and sphenoid (0.91 %) were noted. Conclusion: Corticosteroids and DM are the most important predisposing factors in the development of COVID-19-associated ROCM. Perioperative anesthesia care plays an important role towards management and outcome of ROC mucormycosis. Difficult intubation is anticipated due to fungal debris and supraglottic edema in the oropharynx of the patient.
Anxiety, Depression and Stress among Medical Students during
COVID- 19
Pandemic and their Coping Strategies
Authors: Afreen Saleha , Bhuvaneswari P , KM Susmitha , S Pravallika , Shaik Subahani 
Published: May 2024

Abstract

Background: The COVID-19 pandemic has exacerbated mental health challenges among medical students, already a vulnerable group to mental health disorders. Recent evidence underscores a significant rise in anxiety, depression, and stress among this demographic globally, necessitating a deeper understanding of their mental health status and effective interventions. Objective: This study aims to assess the socio-demographic profile, prevalence rates of depression, anxiety, and stress, as well as coping strategies employed by medical students during the COVID-19 pandemic, with a focus on identifying effective interventions for managing their mental health crises. Methods: A cross-sectional study was conducted among 1st to 4th year MBBS students at ACSR Government Medical College, Nellore, during August and September 2020. Data were collected online using Google Forms, incorporating demographic details and the Depression, Anxiety, and Stress Scale (DASS-21). Descriptive statistics and chi-square tests were utilized for data analysis. Results: The study included 400 participants, 57% of whom were female, with a mean age of 23 ± 2 years. Significant proportions reported experiencing depression (20.2%), anxiety (13%), or stress (51.3%), with notable rates of past psychiatric symptoms. Coping mechanisms included video chatting (35%) and online entertainment (32.2%), while professional help utilization was low (5.5%). COVID-19 repercussions extended beyond mental health, impacting various facets of daily life. Conclusion: This study found various mental health challenges faced by medical students during the pandemic, emphasising the need for ongoing monitoring and psychological support. Additionally, a low rate of seeking professional help was found. Early training in handling pandemic-like situations and mental health is recommended. However, further research is necessary to track mental health progression and ensure accurate diagnosis through individual clinical assessments.
A Rare Case of Spontaneous Stump Ectopic Pregnancy after Adnexectomy
Authors: Metgud Shridevi Chidanand , Prabhu Gauri Abhishek , Garg Bhawna , Neuman Bethany 
Published: May 2024

Abstract
Ectopic pregnancy is an obstetric emergency associated with morbidity. The commonest site for an ectopic pregnancy is the fallopian tube. Occurrence of ectopic in a remnant of tubal stump is a rare form which is not yet classified. Here we present a case of spontaneous stump ectopic pregnancy in a patient who had an adnexectomy. The ruptured remnant end was excised. There is a need to emphasise that the tube should be excised till the cornual end when performing salpingectomy to avoid recanalisation or fistulae formation and stump ectopics.
Case report of Primary Adrenal Insufficiency
Authors: Reddy E Sandeep , Chaitanya Konda , Shailaja Sesha 
Published: May 2024

Abstract
Addison's disease, also known as primary adrenal insufficiency (PAI), is a rare endocrine disorder characterized by a decrease in all three adrenal hormones. This case report describes a 32-year-old female who presented with generalized weakness, fatigue, weight loss, and hyperpigmentation. Based on her symptoms and laboratory findings, a diagnosis of Addison's disease was made. She was started on hormone replacement therapy, and her symptoms improved significantly.