bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between social frailty, use of digital device and depression among community‐dwelling older adults: A population‐based cross‐sectional study
Authors: Hwang Mina , Hwang Yeji 
Published: February 2025

AimSocial frailty is prevalent among community‐dwelling older adults, and it is a leading factor associated with depression in this population. Digital devices can provide opportunities to engage in social or recreational activities, helping to reduce depression in older adults, regardless of their level of social frailty. However, little is known about which specific activities older adults engage in with such devices can lower depression. Therefore, this study aimed to examine which activities are associated with a lower likelihood of developing depression after adjusting for social frailty.MethodsA secondary data analysis was carried out using the 2020 National Survey of Older Koreans, which includes a nationally representative sample of community‐dwelling older adults in Korea (n = 9920). Depression was measured using the Geriatric Depression Scale, social frailty was measured with the Social Frailty Index and digital device use was measured using 11 items from the survey. The 11 items included sending and receiving text messages, searching for information, taking pictures or videos, watching videos, playing games, and more. The data were analyzed using weighted logistic regressions.ResultsIn this study, 13% of participants showed depression. After adjusting for social frailty, the following activities were significantly related to lower odds of depression: playing games (OR 0.618, 95% CI 0.438–0.872, P = 0.006), and searching for and installing applications (OR 0.590, 95% CI 0.372–0.937, P = 0.025).ConclusionsOlder adults engaging in activities using digital devices are less likely to develop depression. Educational programs should be developed to teach older adults about various activities they can perform with digital devices. Geriatr Gerontol Int 2025; ••: ••–••.
Plasma‐Derived von Willebrand Factor/Factor VIII Concentrate (Haemate P) in von Willebrand Disease: A Systematic Review and Pharmacovigilance Update
Authors: Ettingshausen Carmen Escuriola , Lassila Riitta , Escolar Gines , Male Christoph , Schirner Kathrin , Heyder Lisa , Berntorp Erik 
Published: February 2025

ABSTRACTBackgroundVon Willebrand disease (VWD) is an inherited bleeding disorder caused by deficient or dysfunctional von Willebrand factor (VWF). VWF replacement therapy is indicated in VWD management.MethodsThis systematic review was conducted to evaluate all available evidence of the efficacy, safety, dosing and consumption of pasteurized plasma‐derived human coagulation FVIII/human VWF (pdVWF/FVIII; Haemate P/Humate‐P) concentrate for on‐demand (OD) treatment, surgical prophylaxis and long‐term prophylaxis of patients with VWD. A systematic search was performed in MEDLINE and Cochrane Library databases to identify studies (7 June 1982–31 May 2023) reporting the use of pdVWF/FVIII in VWD according to predefined selection criteria. Pharmacovigilance data were also retrieved for the same period.ResultsFifteen studies were identified, 12 being observational and three interventional. Efficacy and safety assessments and treatment protocols varied across the studies which hindered direct comparisons. Haemostatic efficacy of pdVWF/FVIII was rated excellent/good for OD treatment in 95%–98% of bleeds and in 94%–100% of surgeries. In two separate studies, prophylactic efficacy was rated excellent/good in 100% of treatment cycles. Where reported, median annualized bleeding rates decreased from 3–24 prior prophylaxis to 0.5–6 during prophylaxis. Analysis of pharmacovigilance safety reports showed that pdVWF/FVIII was associated with a low rate of adverse events.ConclusionsThis systematic literature review and analysis of pharmacovigilance data summarize evidence of over 40 years of clinical use of pdVWF/FVIII, supporting its safety and efficacy in VWD.
Advances in Helicobacter pylori Antimicrobial Resistance Detection: From Culture‐Based to Multi‐Omics‐Based Technologies
Authors: Kuang Zupeng , Wu Yuwei , Xie Xinqiang , Zhao Xinyu , Chen Huiyuan , Wu Lei , Gao He , Zhao Hui , Liang Tingting , Zhang Jumei , Li Ying , Wu Qingping 
Published: February 2025

ABSTRACTHelicobacter pylori (H. pylori), a proven carcinogenic microbe, necessitates antimicrobial treatment once infected. However, H. pylori worldwide currently faces serious antibiotic resistance (AMR), requiring infected patients to undergo antibiotic susceptibility testing (AST) to guide therapy. Currently, the recommended ASTs for H. pylori are culture‐based methods, which are time‐consuming, complicated, and expensive, impeding their widespread application. With in‐depth researches on the AMR mechanisms of H. pylori, specific gene mutations and novel proteins have been confirmed as the cause of AMR and can serve as targets of ASTs. Accordingly, molecular biology detection has been developed and tremendously shortened the time and reduced difficulty of AST. However, these assays still struggle to meet the enormous testing demand and need for even faster, simpler, and more accurate methods. In recent years, researchers have developed various new platforms based on biosensors, transcriptomics, proteomics, and single‐cell analysis. This review introduces the AMR mechanisms of H. pylori and summarizes the current ASTs from the working principles to application characteristics. Additionally, we draw attention to the potentially applicable techniques for AST of H. pylori from DNA, RNA, protein, and cell perspectives. By systematically recapitulating the past, present, and future of AST for H. pylori, this review provides valuable insights for developing novel assays.
Metabolic dysfunction‐associated steatotic liver disease is a risk factor for gallstones: A multicenter cohort study
Authors: Cho Tomonori , Fukunaga Shuhei , Ohzono Daiki , Tanaka Hiroshi , Minami Shinpei , Nakane Tomoyuki , Mukasa Michita , Yoshinaga Shinobu , Nouno Ryuichi , Takedatsu Hidetoshi , Kawaguchi Takumi 
Published: February 2025

AbstractAimGallstone formation is associated with metabolic dysfunction. Recently, new definitions of steatotic liver disease (SLD) have been proposed, including metabolic dysfunction‐associated SLD (MASLD) and moderate alcohol intake (MetALD). We investigated the effects of MASLD/MetALD on gallstone formation.MethodsThis multicenter observational cohort study enrolled 8766 consecutive health‐check examinees who underwent abdominal ultrasonography between 2008 and 2021 (total observation period 39,105.9 person‐years). All patients were classified into non‐SLD, MASLD, or MetALD groups. The effect of MASLD on gallstone development was evaluated using multivariate Cox regression analysis.ResultsAge, male sex, and MASLD were identified as independent risk factors for gallstone development. MASLD was associated with a significantly higher risk of developing gallstones than non‐SLD (hazard ratio [HR] 1.7112; 95% confidence interval [CI] 1.4294–2.0486; p < 0.0001) and MetALD (HR 1.3516, 95% CI 1.0130–1.8033, p = 0.0406). However, the risk of MetALD did not significantly differ between the SLD and non‐SLD groups. Hypertension was the only significant independent cardiometabolic risk factor for gallstone development in the MASLD group (HR 1.4350, 95% CI 1.0545–1.9528; p = 0.0216). Random forest analysis and directed acyclic graphs identified hypertension as the most important direct factor affecting gallstone development in patients with MASLD.ConclusionsMASLD was an independent risk factor for gallstone development, whereas MetALD presented a similar risk as non‐SLD. Moderate alcohol consumption may reduce the risk of gallstone formation in patients with MASLD. Hypertension may be the most significant cardiometabolic risk factor for gallstone development in patients with MASLD.
Effects of Li+ and/or F− modification methods on the sintering behaviors, microstructures of Mg2SiO4 ceramics
Authors: Bian J. J. , Liu Q. R. 
Published: February 2025

AbstractIn this paper, we prepared four different Mg2SiO4 samples modified by LiF‐addition, LiF‐doping, Li2CO3‐addition, and purely F−doping, respectively to comparatively investigate the effects of the Li+ and/or F− modification methods on the sintering behaviors, microstructures, and microwave dielectric properties of the Mg2SiO4 ceramics. It was found that the sintering behaviors, reactions involved in the process, and corresponding microstructures of the modified Mg2SiO4 ceramics are sensitive to the Li+ and/or F− modification methods. The 2 wt% LiF‐doped, F‐doped, Li2CO3‐added, and LiF‐added samples could be densified at 1575°C/2 h, 1525°C/2 h, 1400°C/2 h, and 900°C/2 h, respectively. The liquid phase sintering justified the enhancement of sinterability by the LiF or Li2CO3‐addition. The lower sintering temperature of the LiF‐added sample than that of the Li2CO3‐added one could be understood by considering the lower melting point (∼800°C) and viscosity of the LiF–SiO2–SiF4 ternary eutectic liquid phase than that of Li2SiO3–SiO2 binary liquid phase (∼1350°C). The easy evaporation of SiF4 for the LiF‐added Mg2SiO4 results in a high porosity of ∼5% after sintering at 900°C. All modified samples demonstrate similar optimized relative dielectric permittivities (εr) of ∼7 and Q × f values of ∼83000 GHz despite slight differences in the porosities and phase assemblages.
Ion sputtering resistance of dense h‐BN thick film prepared via a chemical vapor deposition technique
Authors: Chen Lei , Yao Dongxu , Zhu Ming , Zhao Jun , Xia Yongfeng , Zeng Yu‐Ping 
Published: February 2025

AbstractHexagonal boron nitride (h‐BN) ceramics are promising materials for Hall thruster acceleration channel walls due to their high heat resistance, low thermal expansion, superior thermal shock resistance, and appropriate secondary electron emission coefficients. Nevertheless, its utility is considerably curtailed by a limited service life due to inadequate densification and suboptimal ion sputtering resistance. In this work, dense h‐BN ceramics were fabricated through hot‐press sintering utilizing Y2O3‐Al2O3 as a sintering additive. A chemical vapor deposition (CVD) technique was then employed to create a dense h‐BN thick film on the ceramic surface. Furthermore, an assessment of the sputtering resistance of the obtained h‐BN ceramic and the dense h‐BN thick film is conducted through focused ion beam sputtering. Results show that the sputtering depth of the dense h‐BN thick film is only 50% of that of the h‐BN ceramics under identical conditions. Following the depletion of the thick film, the sputtering loss rate of the h‐BN ceramics with the film matches that of those without. These results underscore the efficacy of depositing a dense h‐BN thick film through CVD, offering a potent strategy for substantially enhancing the ion sputtering resistance of h‐BN ceramics without necessitating alterations in composition.
Cutaneous Side Effects of PD‐1 Inhibitors: A Single‐Center Retrospective Study
Authors: Pozsgai Melánia , Sebastian Udoh Frieda‐Rex , Oláh Péter , Németh Viktória , Gyulai Rolland , Lengyel Zsuzsanna 
Published: February 2025

ABSTRACTBackgroundThe introduction of immune checkpoint inhibitors (ICIs) opened a new era in cancer immunotherapy. In particular, PD‐1 inhibitors have shown remarkable efficacy in various cancers, most notably melanoma. However, the widespread use of immune checkpoint inhibitors comes with the challenge of immune‐related adverse events (irAEs), with cutaneous toxicities being the most prevalent.MethodsA retrospective, single‐center study was carried out to investigate the cutaneous side effects in patients diagnosed with melanoma and treated with PD‐1 inhibitors (pembrolizumab or nivolumab) at the Department of Dermatology, Venereology, and Oncodermatology, University of Pécs, Hungary. The study included patients with stage III or IV melanoma who received PD‐1 inhibitor monotherapy, either for metastatic or adjuvant purposes, from August 2015 to May 2022.ResultsA cohort of 174 patients was examined, with 29% experiencing cutaneous adverse events (cAEs). The most prevalent cutaneous toxicities were vitiligo (n = 18; 27%), maculopapular rash (n = 14; 21%), pruritus (n = 14; 21%), xerostomia (n = 8; 12%), and lichenoid dermatitis (n = 4; 6%). Treatment primarily involved topical corticosteroids and emollients, with a few cases requiring systemic therapy. Notably, the occurrence of dermatologic adverse events was associated with improved progression‐free survival (PFS) (p = 0.007) and overall survival (OS) (p = 0.026) compared to those without any skin toxicity (p < 0.0001), emphasizing their potential prognostic significance. Our data were not influenced by any well‐known prognostic factors of melanoma.ConclusionOur study contributes to the growing body of evidence supporting the prognostic value of cutaneous adverse events in patients treated with PD‐1 inhibitors. Optimizing treatment strategies while maintaining oncologic therapy is essential, highlighting the role of dermatologists in multidisciplinary cancer care.
‘Charge what you think you're worth’: a qualitative study exploring the gender pay gap in medicine and the role of price transparency
Authors: La Brooy Camille , Sabanovic Hana , Méndez Susan J. , Yong Jongsay , Scott Anthony , Elshaug Adam G. , Prang Khic‐Houy 
Published: February 2025

AbstractBackgroundThe gender pay gap in medicine is entrenched and has a negative impact on economic growth, institutional reputation and financial success, recruitment, retention and job satisfaction of female specialists and patient care. It also discourages women from entering specialist fields of medicine. In the Australian unregulated market setting, female specialists are not simply getting paid less, they are choosing to set lower fees than their male counterparts.AimsWe examine how implicit and explicit gender biases affect how fees are set and the potential role of price transparency in addressing the gender pay gap.MethodsWe conducted 27 semi‐structured interviews with medical specialists recruited via social media and medical society newsletters between June 2021 and March 2022. Interviews were recorded and transcribed verbatim. Data were analysed using thematic analysis. Twenty surgeons and seven anaesthetists, 15 of whom identified as male and 12 as female, participated in this study. The primary outcomes and measures focused on the perspectives of surgeons and anaesthetists regarding fee‐setting practices.ResultsA combination of contextual and market‐ and gender‐related factors was the source of the biases that determine fee setting. Further, information asymmetry in medicine in Australia underlies current fee‐setting practices, exacerbating and entrenching false perceptions about women's skills as surgeons and anaesthetists. Women tend to internalise these biases, self‐regulating their behaviours and how they set their fees.ConclusionThe gender pay gap is pervasive. Greater transparency on fees and quality could be explored as a potential solution to reduce pay inequality.
Faculty‐Led Action Research on Simulation‐Based Learning: Enhancing Mental Health Nursing Competency in Undergraduate Education at a Public University in Oman
Authors: Prabha Valsaraj Blessy , K. Y. Divya , Al Gharibi Koukab , Qutishat Mohammed 
Published: February 2025

ABSTRACTNursing programs provide holistic education in caring for people with various health conditions, including mental health conditions. This study aimed to explore the experience of faculty regarding planning and implementing mental health simulation as a method for enhancing the mental health nursing competency training of undergraduate students. The researchers have adopted an action research design under the qualitative paradigm to find answers to the research questions. A purposive sample of nine participants, including mental health nursing faculty and simulation unit staff working in a public university in Oman were included in the study. Ethical clearance was obtained from the institutional ethics committee. Data were collected through in‐depth individual interviews with the faculty. Thematic analysis was done synchronously with the steps of action research through the process of coding, categorising and organising the data into meaningful themes. Member checking was done to ensure the transparency and correctness of the themes and subthemes. Seven themes were derived from thematic analysis of the transcripts, such as ‘Need for creating innovative mental health nursing learning experiences for students’, ‘Perceived readiness for simulation’, ‘Experience in developing mental health simulation’, ‘Arrangement of resources’, ‘The zeal for implementing simulation’, ‘Challenges in the simulation experience’, and ‘Gaining momentum and confidence’. A conceptual framework for simulation in mental health nursing was developed by the authors based on the findings and by referring to existing models. Faculty can effectively plan and implement simulation experiences for their students. Simulation‐based training can become an effective means to make the students more confident and competent in mental health nursing. Implementation of simulation‐based teaching will enhance the quality of nursing education and, thereby, the standard of mental health care in clinical settings.
Interactive Effects of CO2 Enrichment and Nitrogen Levels on Leaf Gas Exchange Capacities of Sweet Potato
Authors: Kumar J. Suresh , Saravanan R. , Ravi V. , Sreekumar J. , Sunitha S. , More Sanket J. 
Published: February 2025

ABSTRACTDifferent nitrogen (N) doses may stimulate the photosynthetic responses of sweet potato under CO2‐enriched environment (ECO2). The photosynthetic responses of two varieties, Sree Arun and Sree Kanaka, were adjudicated under varying nitrogen levels (0%, 25%, 50%, 100%, and 125% of the recommended N dose), exposed to ambient CO2 (400 ppm) and elevated CO2 (600 and 800 ppm). The results indicated that, compared to ambient CO2, the net photosynthetic rate (Pn) and intercellular CO2 (Ci) were significantly increased at ECO2, while stomatal conductance (gs) and transpiration (E) were significantly exacerbated. This resulted in an improved intrinsic (Pn/gs) and instantaneous water use efficiency (Pn/E). Relative humidity and vapour pressure deficit during the time of measurements remained at 73%–85% and ~0.95–1.42 kPa, respectively, at 28°C ± 2°C leaf temperature. Furthermore, the results demonstrated that higher N doses increased photosynthesis and improved plant water relations by modulating stomatal conductance and transpiration rate. Overall, the responses of sweet potato plants to ECO2 and N supply were genotypic‐dependent, and nitrogen application could play an important role in modulating these responses under ECO2. The findings from this study provide valuable insights for tailoring nitrogen‐based management practices for sweet potato in a carbon‐enriched environment.
Artivist Childhoods
Authors: Lasczik Tahlia , Lasczik Alexandra , Cutter‐Mackenzie‐Knowles Amy 
Published: February 2025

AbstractThe rise in the number of young people disengaged from mainstream schooling is reaching critical proportions. This paper explores a child‐framed participatory inquiry known as The Walking A/r/tography Project, which sought to challenge, empower and engage youth at risk in one Special Assistance Secondary School in Southeast Queensland through a/r/tographic mappings of place and subsequent critical and creative experiences in the classroom studio. The young people were invited to the project as researchers, who collected, generated and analysed data, resulting in agentic activist positionings. Extensive literature supports the benefits of an Arts‐rich environment, which can enable impactful social justice learnings and a deep awareness of social and political activism, particularly when they are experienced through contemporary artworks and artmaking practices. Such experiences and knowings can tie learning in, through and with the Arts directly to educational activism, where student voice and agency are foregrounded for the purposes of empowerment and disruptive, transformational learning. The findings of this study assert that young people at risk can co‐create and reimagine their educational experiences to engage in schooling more positively as Artivists.
Impact of Traumatic Stress on Nurses' Work Ability, Job Satisfaction, Turnover and Intention to Leave: A Cross‐Sectional Study
Authors: Comparcini Dania , Simonetti Valentina , Totaro Melania , Apicella Alessia , Galli Francesco , Toccaceli Andrea , Di Lorenzo Antonio , Tafuri Silvio , Cicolini Giancarlo , Tomietto Marco 
Published: February 2025

ABSTRACTAimsThis study aimed to explore the direct and indirect effects of secondary traumatic stress (STS) on nurses' perceived work ability and the effect of these two variables on job satisfaction, organisational turnover intention and intention to leave the nursing profession.DesignA cross‐sectional study was conducted from June to November 2023.MethodData were collected by sending an online survey to a convenience sample of nurses. Instruments for data collection included a 37‐item questionnaire divided into three sections: (i) socio‐demographics, job satisfaction, organisational turnover intention, and intention to leave the profession; (ii) perceived work ability assessed through the Work Ability Index (WAI); (iii) STS measured with the Secondary Traumatic Stress Scale.ResultsTwo hundred seventy‐one nurses completed the questionnaire. STS negatively and statistically impacted on WAI, and it was a direct determinant of intention to leave the nursing profession. WAI showed a direct, positive and significant impact on job satisfaction and it was a significant partial mediator in the relationship between STS and job satisfaction. Job satisfaction mediated between WAI, the intention to leave the nursing profession, and the organisational turnover intention.ConclusionSTS negatively impacted nurses' work ability, influencing their job satisfaction through the mediation of WAI, whereas job satisfaction independently affected nurses' organisational turnover intention. Moreover, STS was a positive and direct determinant of the intention to leave the nursing profession.ImpactNurses, as helping professionals, are exposed to extreme stressful events resulting from the traumatic experiences of patients. STS in nurses can lead to emotional exhaustion, turnover intention, job dissatisfaction and reduced work ability. The findings from this study offer insights that can help shape organisational health policies aimed at reducing STS, preserving nurses' work ability, enhancing job satisfaction and mitigating turnover intentions within and outside the nursing profession.Reporting MethodThis study followed the STROBE checklist guidelines for cross‐sectional studies.Patient or Public ContributionNo Patient or Public Contribution.