bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure, stability, and dynamics of the inclusion complexes formed by auranofin derivatives and hydroxypropyl-β-cyclodextrin
Authors: Santos Hélio F. Dos , Anconi Cleber P. A. 
Published: June 2024

Abstract

The inclusion compounds of auranofin (AF) and its iodide derivative (AF-I) with HP-b-CD were recently identified and characterized experimentally. In the present work, classical molecular dynamics and quantum computational GFN2-xTB method were applied to investigate the inclusion processes. As a result, both approaches addressed the AF-I@HP-β-CD as the most favorable system, as observed experimentally. The higher stability of AF-I@HP-β-CD was explained by entropy and solvation factors, with the GFN2-xTB method providing stability constant (logK1:1) in good agreement with experiment: 0.21 – 1.21 for AF@HP-β-CD and 1.31 – 2.33 for AF-I@HP-β-CD (experimental values are 1.48 and 2.52, respectively). The preferred inclusion mode for AF-I@HP-β-CD has the triethylphosphine (-PEt3) group pointed toward the head portion of the HP-β-CD where the hydroxypropyl groups are attached (labeled as P2). The P2 mode showed short contacts between -CH2CH3 groups (-PEt3) and -H3 only (inside the CD cavity), which is also supported by ROESY experiments.
Correlation analysis of exercise volume and musculoskeletal disorders in people with income level differences: Research based on the 2011–2018 NHANES dataset
Authors: Pan Xiangjun , Liu Shibo , Chen Bo , Yu Zehao , Hao Wang , Tang Xiongfeng , Qin Yanguo 
Published: June 2024

Abstract

Objectives
Socioeconomic factors significantly impact human health; however, the impact of exercise and income on musculoskeletal system health remains unclear. Our study aims to explore the relationship between exercise and income with musculoskeletal system health in young and middle-aged adults.
Design
This cross-sectional study used data from 7,515 adults aged 20–59 years, which were obtained from the US NHANES, 2011–2018. Participants' musculoskeletal system health was evaluated on the basis of them having osteopenia, osteoporosis, or sarcopenia.
Methods
Ordinal regression was used to explore the correlation between income level, exercise volume, and musculoskeletal system health. Mediating effect analysis was used to assess whether the exercise volume affected the impact of income levels on musculoskeletal system health. Ordinal regression and restricted cubic spline curve were used to further analyze the relationship between exercise and income level.
Results
In the analysis of adjusted all covariates, the probability of having good musculoskeletal system health in high-income participants was higher than that of low- or middle-income participants. The probability of having good musculoskeletal system health in the actively exercising group higher than that of the participants exercised insufficiently or sufficiently. Mediating effect of exercise masked the effect of income on musculoskeletal system health. Participants with low income levels tended to spend more time exercising that those who had high income levels; exercise volume and income level had a significant non-linear relationship.
Conclusion
The findings presented will help identify young and middle-aged adults who are most at risk of developing musculoskeletal health problem and will likely benefit from certain lifestyle interventions.
Does vibrotactile biofeedback for postural control interfere with cognitive processes?
Authors: Schulleri Katrin H. , Feizian Farbod , Steinböck Martina , Lee Dongheui , Johannsen Leif 
Published: June 2024

Abstract

Background: Directional vibrotactile biofeedback for balance control can be instructed in the form of Repulsive (to move in the opposite direction of vibrations) or Attractive (to move in the direction of vibrations) stimulus encodings. However, which of these encodings is less cognitively demanding and poses less interference with high-level cognitive processes of conflict resolution remains unresolved.
Methods: In two between-subject studies with 30 (16 females) and 35 (23 females) healthy young adults, respectively, we investigated the cognitive load of Attractive and Repulsive vibrotactile biofeedback on 1) working memory (Study I) and 2) cognitive conflict resolution (Study II). Both studies also examined the effectiveness of both feedback stimulus encodings on balance control during quiet standing with eyes closed.
Results: Both Attractive and Repulsive vibrotactile biofeedback increased balance stability (reduced trunk sway variability) in both the working memory and the conflict resolution study (Study I and II, respectively) with a greater increase of stability for the Repulsive encoding during multitasking demanding cognitive conflict resolution (Study II). Cognitive costs, measured in terms of the Linear Integrated Speed-Accuracy Score (LISAS), were greater for the Attractive encoding during multitasking with working memory demands. When cognitive conflict resolution was required as a secondary cognitive task, both stimulus encodings increased cognitive costs equally.
Conclusions: The effects of instructed Repulsive and Attractive stimulus encodings for the response-related interpretation of vibrotactile biofeedback of body sway were contrasted with respect to cognitive processing demands and balance stabilisation benefits. Both encodings improved balance stability but at certain cognitive costs. Regarding interference with specific high-level cognitive processes, however, a distinction has to be made between both encodings. Repulsive feedback encoding seems to cause less cognitive costs on working memory load and greater stabilisation when cognitive conflict resolution is required. These results are discussed in the context of the known benefits of avoidance actions on cognitive control.
Advanced Detection of Sucker Rod Pump Faults Using Computer Vision and Dynamometer Card Analysis
Authors: Ramadan Amr Gharieb Ali , Algarhy Ahmed , Gabry Mohamed Adel , Zidan Hossam , Darraj Nihal 
Published: June 2024

Abstract

This research explores a new method for monitoring and diagnosing oil wells in artificial lift systems, particularly those using sucker rod pumps (SRP). By combining dynamometer cards, computer vision, and deep learning techniques, we aim to enhance traditional dynamometer card analysis. Our approach involves advanced computer vision and deep learning algorithms to automate interpretation and improve accuracy in identifying issues such as fluid pound, gas interference, and tubing leaks.This method goes beyond relying solely on textual data, which is often limited. We use state-of-the-art deep learning techniques in computer vision to quickly and accurately identify issues, enabling real-time monitoring and predictive maintenance. Testing has shown promising results, with a fault detection accuracy rate of 75-94% in various fault types from dynamometer card images.
The role of fermented grain cereal milling byproduct with Baker's yeast Saccharomyces cerevisiae, enhancement in diets of Nile tilapia (Oreochromis niloticus) fish
Authors: Toutou Mohamed M. , Elmaghraby Ayaat M. , Soliman Ali A. 
Published: June 2024

Abstract

Dietary effects of fermented grain cereal milling by-product (FGC) as a source of carbohydrates on the health, immunology, and overall performance of Nile tilapia fish (Oreochromis niloticus). They split out into four groups: S. cerevisiae Baker's yeast (0, 10, 20, and 40 g/kg diet). Measurements included growth rate, feed utilization, biochemical blood parameters, and gene expression of TNF-α, IGF-1, and GLUT4. The discovery of higher growth indices was linked to the presence of FGC in the diet. Furthermore, it enhances the haematological indicators, which rose in all groups receiving FGC treatment in a substantial way (p ≤ 0.05). Increases in blood levels of total protein, albumin, globulin, and immunological response were observed in fish fed on FGC. This study shows that there was good growth and immunological response, particularly in the 40gm fed diet group where there was a considerable upregulation of the GLUT4, IGF-1, and TNF-α genes. The performance of the (20 g) group was much higher than that of the other groups. Therefore, nutritional (FGC) control may be effective as a tactical strategy to sustain the production of Nile tilapia fish.
Study on the variation of carbon storage in the Chang-Zhu-Tan urban agglomeration in China based on topographic relief
Authors: Mi Yi , Li Sheng , Wu Bo 
Published: June 2024

Abstract

Regional carbon storage is a significant manifestation of ecosystem service functions. Examining the impact of changes in land use on carbon stock in the Chang-Zhu-Tan urban agglomeration under different topographic reliefs is paramount for sustainable land resource utilization and realizing carbon peaking and neutrality goals. Taking the Chang-Zhu-Tan Urban Agglomeration as an example, based on the InVEST model and combined with land use data to analyze the spatio-temporal variation of carbon storage, using the mean change point method to extract topographic relief. From the perspective of topographic relief, this study explores the correlation between changes in land use and carbon storage distribution patterns in the study area. The research results show that the optimal analysis window for topographic reliefs in the study area is 17×17, covering an area of 0.26 km2, with an average topographic relief of 78.58 m. From 2000 to 2020, changes in land use in the Chang-Zhu-Tan urban agglomeration primarily involved a gradual decrease in forest land, cultivated land, and grassland areas and a gradual increase in water and construction land. The carbon stock in the Chang-Zhu-Tan urban agglomeration showed a decreasing trend, with a total reduction of 13.37×106 tons over the past 20 years. The distribution of carbon stock across topographic reliefs mainly exhibits low-value and moderate-value carbon stock concentrations in flat and slightly undulating areas. In contrast, moderately high-value and high-value carbon stock concentrations are concentrated in gently and moderately undulating areas. These research findings provide a scientific foundation for optimizing the spatial pattern of the study area and formulating carbon peak and carbon-neutral policies.
Adaptation strategies for cumin in Sabzevar, Iran: planting date and irrigation management
Authors: Rivandi Hasan , Rezvan Shahram , Moeini Matin Jami , Sinaki Jafar Masoud , Damavandi Ali 
Published: June 2024

ABSTRACT
The current study aimed to investigate the effect of planting date and irrigation on some characteristics of cumin cultivated in Iran. The experimental characteristics included three planting dates and five irrigation regimes. Irrigation at flowering + seed filling stage and full irrigation had the highest essential oil content (3.6%) and plant height (16.71 cm), respectively. On all planting dates, irrigation enhanced the total chlorophyll and carotenoids content, relative water content, umbel number plant−1, seed number umbel−1, 1,000-seed weight, and seed yield but reduced the proline content and water-use efficiency (WUE). The highest chlorophyll content (1.54 mg g−1 fresh weight (FW)), carotenoids content (0.35 mg g−1 FW), umbel number plant−1 (18.03), seed number umbel−1 (21.16), 1,000-seed weight (4.12 g), seed yield (1002.7 kg ha−1), and essential oil yield (22.13 kg ha−1) were obtained on 19 January and irrigation at the flowering + seed filling stages. The greatest amount of WUE (0.53 kg m−3) was measured on 9 January under no irrigation condition. Therefore, to produce cumin under similar climatic conditions, early planting of cumin in early January, along with two irrigations at the flowering and seed filling stages, is recommended.
Qualitative analysis of physico-chemical parameters of packaged drinking water commercially available in India
Authors: Thakur Archana , Singh Jaspal 
Published: June 2024

ABSTRACT

The demand for packaged drinking water is increasing day by day, so it is necessary that the quality of this water must be monitored. Our present study focuses on the determination of the concentration of minerals and trace elements present in commercialised packaged drinking water sold out in various regions of India. In total, we have analysed 41 brands. The different treatments through which this water has passed as claimed by the manufacturers are also mentioned. The average value of the total dissolved solids in these waters is found to be 101.1 mg L−1. The content of anions and cations present in water is represented by box and whisker plots. Bottled water samples are also analysed for the radioactive element uranium, which is observed in the range of &lt;0.1 to 9.2 μg L−1 with a mean concentration of 1.6 μg L−1. The radiation dose assessment for various age groups has been calculated due to the ingestion of uranium present in the water.
Uncommon Coexistence of Systemic Lupus Erythematosus and Psoriatic Arthritis: A Case-Based Review
Authors: Venetsanopoulou Aliki I. , Katsigianni Ioanna , Skouvaklidou Elpida , Vounotrypidis Periklis , Voulgari Paraskevi V. 
Published: June 2024

Abstract:
Cases of systemic lupus erythematosus (SLE) following psoriatic arthritis (PsA) or vice
versa are uncommon. Due to the complexity of autoimmune diseases and the rarity of such cases,
comprehensive global data on the co-occurrence of these conditions are limited. Moreover, the
pathophysiology concerning the coexistence of SLE and PsA has yet to be fully understood. Interestingly,
the progression of both diseases appears to be significantly influenced by the key interleukin
(IL) 17, particularly IL-17A.
Here, we report 7 cases of SLE and PsA coexistence. In 5 of these cases, PsA occurred before the
development of SLE, while in the remaining 2 cases, SLE was diagnosed before PsA. The PsA
was characterized mainly by peripheral arthritis without any axial involvement, while the manifestations
of SLE varied, with 3 developing systematic severe manifestations. Therapeutic challenges
were posed in all cases, as treating one condition could worsen the other.
Finally, we review the literature providing the current knowledge on the coexistence of these conditions.
Overall, all reported cases emphasize the importance of personalized treatment and careful
monitoring for patients with both SLE and PsA.
The Potential of Radiolabeled Bisphosphonates in SPECT and PET for Bone
Imaging
Authors: Ashhar Zarif , Ahmad Fadzil Muhammad Fakhrurazi , Hassan Hishar , Othman Muhamad Faiz , Md Hassan Mohd Borhanuddin , Chun Vui Vincent Yong , Guat Choo Chan , Yusof Nor Azah 
Published: June 2024

Abstract::
Skeletal-related events due to bone metastases can be prevented by early diagnosis using radiological or nuclear imaging techniques. Nuclear
medicine techniques such as Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been used
for diagnostic imaging of bone for decades. Although it is widely recognized that conventional diagnostic imaging techniques such as Computed
Tomography (CT) and Magnetic Resonance Imaging (MRI) have high sensitivity, low cost and wide availability, the specificity of both techniques
is rather low compared to nuclear medicine techniques. Nuclear medicine techniques, on the other hand, have improved specificity when
introduced as a hybrid imaging modality, as they can combine physiological and anatomical information. Two main radiopharmaceuticals are used
in nuclear medicine: [99mTc]-methyl diphosphonate ([99mTc]Tc-MDP) from the generator and [18F]sodium fluoride ([18F]NaF) from the cyclotron.
The former is used in SPECT imaging, while the latter is used in PET imaging. However, recent studies show that the role of radiolabeled
bisphosphonates with gallium-68 (68Ga) and fluorine-18 (18F) may have a potential role in the future. This review, therefore, presents and discusses
the brief method for producing current and future potential radiopharmaceuticals for bone metastases.
Paracetamol-induced Liver Injury in An Experimental Rat Model: Noninvasive
Assessment using DKI and the Effect of Gadoxetate on DKI Parameters
Authors: Xu Lixue , Yang Dawei , Chen Dan , Xu Hui , Zheng Jing , Cheng Tianxin , Ren Hao , Wang Yan , Zhao Xinyan , Yang Zhenghan 
Published: June 2024

Purpose:
To explore the potential of diffusion kurtosis imaging (DKI) for assessing the degree of liver injury in a paracetamol-induced rat model and to
simultaneously investigate the effect of intravenous gadoxetate on DKI parameters

Methods:
Paracetamol was used to induce hepatoxicity in 39 rats. The rats were pathologically classified into 3 groups: normal (n=11), mild necrosis (n=18),
and moderate necrosis (n=10). DKI was performed before and, 15 min, 25 min, and 45 min after gadoxetate administration. Repeated-measures
ANOVA with Tukey’s multiple comparison test was used to investigate the effect of gadoxetate on mean diffusivity (MD) and mean diffusion
kurtosis (MK) and to assess the differences in MD and MK among the three groups. A receiver operating characteristic (ROC) curve analysis was
performed to evaluate the diagnostic accuracy of the MD values when discriminating between the necrotic groups

Results:
Gadoxetate had no significant effect on either the MD or the MK, and the effect size was small. The MD in the moderate necrosis group was
significantly lower than that in the other two groups (F = 13.502, p <0.001; η2 = 0.428 [95% CI: 0.082-0.637]), while the MK did not significantly
differ among the three groups (F = 2.702, p = 0.081; η2 = 0.131 [95% CI: 0.001-0.4003]). The AUCs of MD for discriminating the moderate
necrosis or normal group from the other groups were 0.921 (95% CI: 0.832-1.000) and 0.831 (95% CI: 0.701-0.961), respectively.

Conclusion:
It would be better to measure the MD and MK before gadoxetate injection. MD showed potential for assessing the degree of liver necrosis in a
paracetamol-induced liver injury rat model.
Risk Prediction of Type 2 Diabetes Mellitus by MRI-based Pancreatic
Morphology and Clinical Characteristics: A Cross-sectional Study
Authors: Yan Yunjing , Wu Tengyue , Huang Zhengkuan , Song Xueliang , Huang Xiaohua , Liu Nian 
Published: June 2024

Objectives::
This study aimed to investigate the pancreatic morphology and clinical characteristics to predict risk factors of type 2 diabetes mellitus (T2DM)
based on magnetic resonance imaging.

Methods::
A total of 89 patients (T2DM group) and 68 healthy controls (HC group) were included. The T2DM group was divided into a long-term T2DM
group and a short-term T2DM group according to whether the illness duration was more than 5 years. The clinical characteristics were collected,
including sex, age, fasting plasma glucose, glycosylated hemoglobin, and lipoproteins. The pancreatic morphological characteristics, including the
diameters of the pancreatic head, neck, body, and tail, the angle of the pancreaticobiliary junction (APJ), and the types of pancreaticobiliary
junction were measured. The risk prediction model was established by logistic regression analysis.

Results::
In the long-term T2DM group, the pancreatic diameters were smaller than the other two groups. In the short-term T2DM group, the diameters of
the pancreatic tail and body were smaller than the HC group. The APJ, very low-density lipoprotein, and triglyceride levels in the two T2DM
groups were greater than the HC group, and the APJ of the short-term T2DM group was smaller than the long-term T2DM group. Pancreatic
diameters showed a negative correlation with illness duration. Logistic regression analysis revealed pancreatic body diameter was a protective
factor, and APJ was a risk factor for T2DM. Prediction model accuracy was 90.20%.

Conclusions::
The morphology of the pancreas is helpful to predict the risk of the onset of T2DM. The risk of onset of T2DM increases with smaller pancreatic
body diameter and higher APJ.
Analytical-petrographic Study of Bugnato Degradation of an Ancient Milan Building
Authors: Tomassetti Mauro , Castrucci Mauro , Dell'Aglio Emanuele , Sammartino Maria Pia , Visco Giovanni , Martini Elisabetta , Innocenzi Francesca , Reale Rita , Ronca Sara 
Published: June 2024

Aim:
The ashlar belongs to a classic palace located in the city of Milan (Italy), built in
1883 by a renowned architect of the time. It was studied in detail in order to establish the material it
is made of and to highlight its degradation and what caused it.

Methods:
The study was carried out by combining different techniques, for example, a detailed
minero-petrographic study was performed, together with classical chemical qualitative and quantitative
analyses of all the main cations and anions present, using ion chromatography and UV-Vis spectrophotometry.
On the other hand, most of the classic instrumental analytical methodologies were
also performed, such as powder X-ray diffractometry, thermal analysis (TG, DTG, and DTA), and
SEM spectroscopy.

Results:
In this way, it was possible to know its composition, hypothesize the origin of the material,
highlight the type of degradation, and study the main likely causes.

Conclusion:
The focus of the research, in our opinion, lies both in the scarcity of published studies
regarding this type of artefact, especially if it belongs to the period of the artefact we investigated,
and in having demonstrated how chemical and instrumental analyses of different types, can contribute
to obtaining different information and how, above all, their results are useful for the mutual validation
of the results themselves.
Changes in the Global Mortality Rate Over Time in Association with the COVID-19 Pandemic Until 2032
Authors: SeyedAlinaghi SeyedAhmad , Khajeh Akhtaran Fatemeh , Abbaspour Faeze , Mehraeen Esmaeil , Dadras Omid 
Published: June 2024

Introduction:
To shed light on the potential trajectories in the global mortality rate, the
central question posed is the trajectory of global death rates in the years to comeThis study was an
effort to predict the trend of the global mortality rate following the COVID-19 pandemic until 2032
and, based on it, an attempt to contemplate potential solutions available for decision-making and
planning.

Methods:
We employed a time series model to predict future mortality rates based on global mortality
rate data. Although several forecasting methods exist for time series data, this study utilized the
Autoregressive method. This approach facilitatedregression and prediction based on past mortality
numbers. To predict mortality rates from 2023 to 2032, we applied an autoregressive model on mortality
rate data spanning 1980 to 2022.

Results:
The predicted global mortality rate in the next 10 years (post-pandemic era) appeared to be
higher than the 10 years before COVID-19 (pre-pandemic era). This projection indicates that despite
a declining trend in mortality rates since 2023, the mortality rate from 2023 to 2032 exceeds that of
the pre-COVID-19 years. We predict that the ongoing COVID-19 outbreak, although transitioning
out of a crisis state, will result in an approximate increase in the global mortality rate over the next
10 years.

Conclusion:
Our results indicate a noteworthy increase in the global mortality rate following the
emergence of COVID-19. Furthermore, our findings suggest that the mortality rates will remain high
in the future. Further research is necessary to attain more accurate insights into this matter.