bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the Mechanisms of Lithium‐Alloy Plating in Ag–C Anode: In situ SEM Study
Authors: Kamikawa Y. 
Published: February 2025

AbstractThe Ag–C composite anodes facilitate stable LixAg deposition in solid‐state batteries. However, the role of carbon and the kinetics of lithium migration and deposition in the composite structure remain unclear. Few studies have focused on this critical research area owing to a shortage of effective, non‐destructive characterization methods that can directly observe the Li alloy deposition process in solid‐state batteries in real time. In this study, Li alloy formation on the Ag–C anode is investigated through operando X‐ray diffraction (XRD) analysis and scanning electron microscopy combined with in situ probing. This enables the observation of the composition and morphology of the LixAg alloy as it evolves within the Ag–C composite anode during discharge. Further insights from scanning transmission electron microscopy–electron energy loss spectroscopy and first‐principles simulations on lithiophilicity and the energy barrier for lithium migration reveal a complex lithium migration and deposition mechanism within the Ag–C anode.
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response
Authors: Zhang Ninan , Lin Ruifan , Gao Wenya , Xu Honglin , Li Yuejia , Huang Xiahe , Wang Yingchun , Jing Xianghong , Meng Wenxiang , Xie Qi 
Published: February 2025

AbstractNeuroinflammation is often characterized by an overactive microglial response. Curcumin, known for its anti‐inflammatory and antioxidant properties, can mitigate microglial hyperactivity following epileptic seizures. The study delves into the molecular mechanisms underlying curcumin's modulation of RNA post‐transcriptional N (6)‐methyladenosine (m6A) modification. It is found that curcumin interacts with the Z1‐type protein tyrosine phosphatase receptor (PTPRZ1), maintaining its enzymatic activity and thus regulating the phosphorylation of the m6A‐reader YTH domain‐containing family protein 2 (YTHDF2). This modulation affects the expression of critical genes, resulting in reduced inflammatory responses. These findings highlight the importance of post‐transcriptional modifications of RNA in the neuroprotective and anti‐inflammatory effects of curcumin, offering new insights for the treatment of related diseases.
3D‐AJP: Fabrication of Advanced Microarchitected Multimaterial Ceramic Structures via Binder‐Free and Auxiliary‐Free Aerosol Jet 3D Nanoprinting
Authors: Hu Chunshan , Jahan Sanjida , Yuan Bin , Panat Rahul 
Published: February 2025

AbstractManufacturing of ceramics is challenging due to their low toughness and high hardness. Additive Manufacturing (AM) has been explored to create complex ceramic structures, but current techniques face a tradeoff between precisely controlled feature sizes and high shrinkage at the microscales. Here, we introduce 3D‐AJP, a novel freeform ceramic fabrication method that enables highly complex microscale 3D ceramic architectures—such as micropillars, spirals, and lattices—with minimal shrinkage and no auxiliary support. Using a near‐binder‐free nanoparticle ink in an Aerosol Jet (AJ) 3D printer, our approach precisely controls feature sizes down to 20 µm with aspect ratios up to 30:1. The resulting structures exhibit exceptionally low linear shrinkage of 2‐6% upon sintering, spanning five orders of magnitude in length scale. Bi‐material 3D architectures (zinc oxide/zirconia, zinc oxide/titania, titania/zirconia) and hybrid ceramics further demonstrate the technique’s versatility. We showcase two key applications. First, 3D ceramic photocatalysts improve water purification performance, achieving a 400% increase in photocatalytic efficiency compared to bulk ceramics. Second, we develop a highly sensitive Her2 biomarker sensor for breast cancer detection, achieving a 22‐second response time and a record‐low detection limit of 0.0193 fm. Our technique will lead to high‐performance sensing, filtration, microelectronics packaging, catalysis, and tissue regeneration technologies.
Vitamin C‐Dependent Intergenerational Inheritance of Enhanced Endurance Performance Following Maternal Exercise
Authors: Shi Haiwang , Li Jie , Li Fan , Yu Haoyang , Zhang Fulong , Wu Tao , Yang Luodan , Li Yuecheng , Hu Rui , Chen Mengjie , SG Nina , Zhuang Xuhong , Feng Shu , Zhu Ling , Duan Rui 
Published: February 2025

AbstractDeclining levels of physical activity and fitness in children and youth are linked to negative health outcomes. This study investigates whether maternal exercise can enhance offspring's physical fitness. Our results demonstrate that maternal exercise improves offspring's endurance by changing muscle fiber composition and promoting mitochondrial biogenesis, with benefits lasting across generations. This improvement is associated with changes in DNA methylation, specifically the demethylation of the Slc23a2 gene, which codes for SVCT2, crucial for vitamin C (VC) transport, in F1 and F2 generations. Importantly, VC administration during pregnancy mimics the transgenerational benefits of exercise on offspring fitness, but these benefits are absent in genetic VC deficiency mice. VC supplementation increases TET2 expression in murine and human myogenic cells, regulating DNA methylation, promoting the development of oxidative fibers, and enhancing mitochondrial biogenesis. This study highlights the VC‐TET2‐SVCT2 pathway as a key mechanism for the transgenerational endurance benefits of maternal exercise, suggesting potential strategies to enhance maternal and child health.
Cell‐Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory
Authors: Li Lanfang , Guo Yiqing , Jing Wei , Tang Xiaomei , Zeng Jinyu , Hou Zhenye , Song Yige , He Aodi , Li Hao , Zhu Ling‐Qiang , Lu Youming , Li Xinyan 
Published: February 2025

AbstractMammillary body (MB) is traditionally viewed as a structural node of an anatomic circuit for emotion and memory. However, little is known about its molecular and cellular organizations. Here, a discovery that MB contains four subtypes of neurons that occupy different spatial subregions is reported. Of these, two subtypes of neurons are tagged by parvalbumin (PV) and dopamine receptor‐D2 (Drd2) markers. PV neurons are spontaneously active, whereas Drd2 neurons are inactive at rest and generate rebound bursts. These two distinct electrophysiological properties are encoded by Kcnn4 and Cacna1h. PV and Drd2 neurons generate two distinct cell‐type specific circuits by receiving inputs from two discrete subiculum neuronal classes. Gain‐ and loss‐of‐function studies on these cortical‐subcortical circuits demonstrate their differential roles for place and object recognition memory. This finding provides a comprehensive molecular and structural atlas of MB neurons at single‐cell resolution and reveals that MB contains molecularly, structurally, and functionally dissociable streams within its serial architecture.
Nanoenhanced‐Cuproptosis Results From the Synergy of Calcium Overload and GSH Depletion with the Increasing of Intracellular Ca/Mn/Cu Ions
Authors: Liu Shiwei , Yan Wennan , Zhang Wenyue , Zhang Ji , Li Ziyi , Guo Yingshu , Chen Hong‐Yuan , Xu Jing‐Juan 
Published: February 2025

AbstractCuproptosis is a newly discovered copper‐dependent form of cell death. Intracellular glutathione (GSH) acts as a copper chelator to inhibit cuproptosis, so the reduction of GSH concentration is conducive to enhancing the cuproptosis of cells. In order to reduce GSH content and interfere with mitochondrial metabolism, a strategy based on calcium overload and GSH depletion to enhance cuproptosis is proposed in this study. Containing manganese (Mn) and copper (Cu) elements, CaCO3 nanoparticles (NPs) are modified with MCF‐7 cell aptamer (CaCO3/Mn/Cu@lip‐Apt). When entering the cell, CaCO3/Mn/Cu@lip‐Apt decomposed and released Mn* (Mn2+/Mn3+/Mn4+), Cu2+ and Ca2+. The high valence Mn ion in Mn* can effectively consume GSH to produce Mn2+ which catalyzed H2O2 to produce reactive oxygen species (ROS), while reducing the GSH concentration. The production of ROS promoted the influx of exogenous Ca2+. The large accumulation of Ca2+ led to intracellular calcium overload, resulting in mitochondrial dysfunction and metabolism disorders. The depletion of GSH promoted the accumulation of Cu2+, which in turn triggered cuproptosis. This strategy showed excellent antitumor effects and provided a new way to study disease treatment.
Ternary Schottky Junction for Sonocatalytic Water Splitting in Gas‐Immunotherapy‐Mediated Cancer Treatment
Authors: Zhang Rui , Wang Qian , Pan Junjie , Du Jun , Yang Han , Wang Bingfeng , Li Yuhao , Miao Yuqing , Hou Xumin , Wu Jingxiang , Miao Qing 
Published: February 2025

AbstractHydrogen therapy has shown new potential in cancer treatment, particularly in high‐pressure and hypoxic areas, where it demonstrates the ability to alter the tumor microenvironment and regulate tumor metabolism. Hydrogen disrupts the mitochondrial function of cancer cells, interferes with their energy metabolism, and ultimately leads to energy depletion and apoptosis. In this study, a sonocatalyst (BPM), is designed to generate hydrogen and oxygen in situ within tumors, further enhancing the therapeutic efficacy. The mesocrystalline structure of BPM, composed of bismuth fluoride, polyoxometalates, and molybdenum carbide, significantly improves charge separation and electron transfer efficiency under ultrasound irradiation, resulting in an efficient water‐splitting reaction. By simultaneously generating hydrogen and oxygen within the tumor microenvironment and depleting glutathione, BPM effectively triggers oxidative stress and alleviates hypoxia, thereby disrupting mitochondrial function and inhibiting energy metabolism in cancer cells. Additionally, BPM enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, and polarizing macrophages toward the M1 phenotype, reversing the immunosuppressive state of the tumor microenvironment. The results indicate that BPM holds potential for gas‐immunotherapy combination treatments, offering a multifunctional strategy to improve cancer therapy outcomes.
A Novel tRF, HCETSR, Derived From tRNA‐Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1‐catenin Complex Axis
Authors: Rui Tao , Zhu Kangbei , Mao Zonglei , Wu Jiaping , Pan Yi , Ye Qianwei , Chen Cong , Xiang Aizhai , Guo Jufeng , Tang Ning , Zhang Jing , Zheng Shusen , Liu Jian , Xu Xiao 
Published: February 2025

AbstracttRNA‐derived fragments (tRFs), a novel class of small non‐coding RNAs cleaved from transfer RNAs, have been implicated in tumor regulation. In this study, the role of a specific tRF, HCETSR is investigated, which is significantly downregulated in hepatocellular carcinoma (HCC) and correlates with advanced tumor burden and higher HCC mortality. Functional analyses revealed that HCETSR inhibits HCC malignancy and serves as an independent predictor of poor prognosis. Mechanistically, a novel SPTBN1/catenin complex axis regulated by HCETSR is identified. HCETSR binds to a critical domain of SPTBN1, disrupting its interaction with the catenin complex (comprising β‐catenin, α‐catenin, and P120‐catenin), and facilitates the transfer of the catenin complex from the cell membrane to the nucleus. Specifically, HCETSR decreases the proteasomal degradation of β‐catenin and inhibits the synthesis of nascent β‐catenin. Furthermore, HCETSR suppresses the transcriptional activity of LEF1 through P120‐catenin rather than α‐catenin, thereby reducing β‐catenin's influence on LEF1 activity. It is demonstrated that HCETSR is spliced from tRNA‐Glu/TTC. The biogenesis of HCETSR and tRNA‐Glu/TTC is regulated by the spliceosome and Dicer1. In conclusion, These findings suggest that HCETSR, derived from tRNA‐Glu/TTC, inhibits HCC malignancy via modulation of the SPTBN1/catenin axis and may represent a promising prognostic marker and therapeutic strategy for HCC.
High‐Efficiency Water Collection of Superhydrophobic Condensation Absorber
Authors: Yan Defeng , Lin Junyi , Chen Yang , Yang Xiaolong , Lu Yao , Song Jinlong 
Published: February 2025

AbstractThe atmosphere contains ≈1.3 billion tons vapor that can be condensed to obtain water, which has the promise of alleviating the water crisis. However, condensed droplets are difficult to shed from the condensation surface that means a low surface refreshing frequency, showing the low water collection rate and efficiency. Here, this limitation is successfully overcome by proposing a novel superhydrophobic condensation absorber (SCA). All surfaces of the SCA are superhydrophobic but covered with a series of superhydrophilic through pores and superhydrophilic points which enabled the SCA with a rapid droplet nucleation capability. The whole condensation processes exhibit that the SCA has the extremely small droplet shedding volume and the highly frequent surface refreshing, which are 0.00003 and 1.1× 106 times that of the existing water collection method, respectively. The water collection rate of SCA is superior than that of the existing water collection methods, reaching to 80 mg cm−2 h−1 at the subcooling temperature of only 10 °C. In addition, the collected water by this SCA is clean without any contaminant. This high‐efficiency and eco‐friendly water collection method will maximize the acquisition of clean water from atmosphere, which has a strong implication for the people suffering from the freshwater crisis.
In Situ Construction of IrOx Nanofilm on TiOx for Boosting Low‐Ir Catalysis in Practical PEM Electrolyze
Authors: Qin Yufeng , Huang Yixuan , Ye Qingqing , Wang Jiahao , Endo Morinobu , Dou Meiling , Wang Feng 
Published: February 2025

AbstractExploring low‐iridium (Ir) electrocatalysts for oxygen evolution reaction (OER) is exigent to promote the commercialization of proton electrolyte membrane water electrolyzers (PEMWEs). Herein, the study presents a scalable and facile strategy to in situ construct an IrOx nanofilm continuously coated on TiOx support as efficient and durable OER catalyst through one‐step annealing of Ir‐salt‐adsorbed titanium‐based metal–organic frameworks (MOFs) precursor. The unique nanofilm structure forms a continuous p‐n junction interface, endowing a strong interfacial electron transfer from TiOx to IrOx and also ensuring a well‐connected conductive network in the anodic catalytic layer due to the continuous dispersion of IrOx. The optimal catalyst requires a low overpotential of 233 mV at 10 mA cm−2 with a 40‐fold of com. IrO2 in mass activity. The assembled PEMWE shows a cell voltage of 1.762 V at 1 A cm−2 with ≈220 h durable operation under start/shut‐down operation. Operando characterizations and theoretical calculation reveal that the p‐n junction not only reduces the energy barrier of water dissociation and deprotonation step of *OOH boosting OER kinetics but also prevents oxidation of Ir sites to form soluble Ir species that improves durability. This work offers a new avenue to rationally design and synthesize efficient low‐Ir OER catalyst for PEMWE application.
Optimizing groundnut sowing for minimizing dry spell risks over Rayalaseema, a rainfed region of India
Authors: Ashok Kumar K. , Malleswari S. N. , Sudheer K. V. S. , Bal Santanu Kumar , Manikandan N. , Subba Rao A. V. M. , Sarath Chandran M. A. 
Published: February 2025

AbstractGroundnut productivity in rainfed regions of arid and semi‐arid agro‐ecosystems in southern India is highly vulnerable to intra‐seasonal rainfall variability as well as the timing, duration, frequency, and intensity of dry spells. The Rayalaseema semi‐arid region of India, a major groundnut (Arachis hypogaea L.)‐growing region, has experienced increasing intra‐seasonal rainfall variability, especially over the last few decades. To understand the impacts of dry spells on the growth and development of groundnut, field experiments on groundnut (cultivar K6) were conducted at the Agricultural Research Station, Ananthapuramu, Andhra Pradesh, during 2015–2020. The results indicated that the amount and distribution of rainfall during different phenophases were the most influential parameters on dry matter production, phenology, and pod yield in groundnut and can have either a positive or negative effect depending on whether the rainfall matches the crop's water requirements during specific growth stages. It was found that, in July second fortnight (II‐FN) sown crop, the rainfall received was synchronized with pod initiation to maturity stage, resulting in higher dry matter production (456 g m−2) and pod yield (1123 kg ha−1). On the other hand, pod initiation‐pod maturity stage with August I‐FN sown crop received less rainfall, leading to a soil moisture deficit and lower pod yields (815 kg ha−1). The duration of pod initiation‐pod maturity stage with August I‐FN sown crop was significantly less (47 days) compared to July II‐FN (54 days) and July I‐FN (50 days) sown crops, resulting in reduced pod filling period that drastically affected pod yield. It can be concluded that the existing sowing time for groundnuts needs to be advanced from August I‐FN to July II‐FN. This will not only avoid terminal moisture stress during pod initiation‐pod maturity stage but also help in enhancing groundnut productivity in rainfed areas of Rayalaseema region.
Estimating hard winter wheat yield with historical and novel methods
Authors: Sciencia Maria C. M. , Creech Cody F. , Frels Katherine A. , Easterly Amanda C. 
Published: February 2025

AbstractEstimating potential crop yield during the growing season allows growers to adjust inputs, set reasonable harvest expectations, and guide marketing decisions. Therefore, the ability to estimate yield is a valuable yet difficult goal for growers. To evaluate the potential of several methods of wheat (Triticum aestivum L.) grain yield prediction, this experiment used published methods based on phenological characteristics: stand and tiller/spike counts, and newer methods that employ image‐ and reflectance‐based approaches, such as fractional green canopy cover (FGCC) and normalized difference vegetation index (NDVI) readings. This experiment was conducted across six locations (Banner, Box Butte, Cheyenne, Intensively Managed at Cheyenne, Deuel, and Kimball counties) in western Nebraska during 2019–2020, 2020–2021, and 2021–2022 for a total of 11 site‐years. Treatments consisted of seven winter wheat varieties that were evaluated in the Winter Wheat State Variety Trials. Stand count did not show a significant correlation with wheat yield (0.09) nor model fit for yield estimation. Spike count was significantly correlated with yield (0.54), but efforts to use it to estimate final yield were not significant. Due to the inconsistency of yield prediction with historical methods, analyses of novel methods of yield estimation were warranted. NDVI and FGCC readings correlate with wheat yield and model fit efforts were successful. NDVI at Feekes 10 correlated significantly at 0.39, while FGCC had correlations of 0.56, 0.50, and 0.68 at Feekes 2, 4, and 10 (respectively). This experiment suggests that NDVI and FGCC are methods that could be used to replace outdated and laborious approaches.
Clinico‐Genomic Interrogation of Secondary‐Type Acute Myeloid Leukemia: Response and Outcomes to Contemporary Therapies
Authors: Senapati Jayastu , Loghavi Sanam , Marvin‐Peek Jennifer , Garcia‐Manero Guillermo , Kadia Tapan M. , Borthakur Gautam , Daver Naval , Short Nicholas J. , Jain Nitin , Issa Ghayas C. , Haddad Fadi , Hammond Danielle , Chien Kelly , Tang Guillin , Thakral Beenu , Montalban‐Bravo Guillermo , Pemmaraju Naveen , Bazinet Alexandre , Swaminathan Mahesh , Pierce Sherry , Abbas Hussein A. , Reville Patrick , Popat Uday , Shpall Elizabeth , Champlin Richard , Jabbour Elias , Ravandi Farhad , Kantarjian Hagop M. , DiNardo Courtney D. 
Published: February 2025

ABSTRACTOntogeny of acute myeloid leukemia (AML) provides prognostic information, however closer interrogation with respect to AML characteristics, genomics, and various treatments are warranted. We defined untreated clinical secondary (CS) AML as AML with a diagnosis of antecedent myelodysplastic syndrome (MDS) or MDS/myeloproliferative neoplasm (MDS‐MPN) without exposure to hypomethylating agents or chemotherapy; genomic secondary (GS) AML included patients with myelodysplasia related cytogenetics (MRC) or myelodysplasia related mutations (MRM) without a known antecedent myeloid neoplasm or prior chemo‐radiotherapy for non‐myeloid neoplasms. Among newly diagnosed AML patients classified as untreated CS‐AML (n = 133) or GS‐AML (n = 389), median relapse‐free survival (RFS) (11.9 vs. 12.4 months, p = 0.36) and overall survival (OS) (11.6 vs. 14.4 months, p = 0.75) were similar. No difference in RFS and OS between these groups treated with low‐intensity therapy (LIT) and venetoclax regimens was seen, but both were inferior to de novo (DN) AML without secondary‐type genomics (pure DN‐AML). GS‐AML defined by the presence of only MRM had superior OS compared with MRM ± MRC with LIT+ venetoclax therapy (RFS 19.5 vs. 6.8 months [p < 0.01] and OS 29.6 vs. 8.4 [p < 0.01]) and had similar RFS (29.8 months, p = 0.48) and OS (32.0 months, p = 0.48) to pure DN‐AML treated with LIT+ venetoclax. On multivariate analysis in patients treated with LIT+ venetoclax, untreated CS‐AML (vs. GS‐AML), adverse cytogenetics and ELN 2024 adverse‐risk disease (mutated TP53) were associated with higher hazard of death. Adverse cytogenetics was the strongest prognostic variable predicting survival. Mutation‐driven genomic ontogeny of newly diagnosed AML with MRM appears less prognostic than cytogenetic‐driven ontogeny with venetoclax‐based therapy.
Base‐Promoted Construction of Benzo[4,5]imidazo[1,2‐c][1,3]thiazinethiones via C−N/C−S Cyclization
Authors: Tran Quynh Nhu , Truong Thanh Ngoc , Pham Hong Ngoc , Phung Van Trung , Dao Pham Duy Quang 
Published: February 2025

AbstractIn this work, 2‐bromoaryl‐ and 2‐bromovinylbenzimidazoles reacted with carbon disulfide as building block in DMF in the presence of NaH to yield the corresponding benzo[4,5]imidazo[1,2‐c][1,3]thiazinethiones. A proposed reaction pathway for this environmentally friendly process involves a nucleophilic addition followed by an unprecedented transition metal‐free cyclization to form C−N and C−S bonds.