bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth retardation in untreated autosomal dominant familial neurohypophyseal diabetes insipidus caused by one recurring and two novel mutations in the vasopressin-neurophysin II gene
Authors: Brachet Cécile , Birk Julia , Christophe Catherine , Tenoutasse Sylvie , Velkeniers Brigitte , Heinrichs Claudine , Rutishauser Jonas 
Published: November 2010

ObjectiveAutosomal dominant familial neurohypophyseal diabetes insipidus (adFNDI), a disorder caused by mutations in the vasopressin (AVP)-neurophysin II (NPII) gene, manifests gradually during early childhood with progressive polyuria and polydipsia. Patients are usually treated with synthetic AVP analog. If unlimited access to water is provided, prognosis is usually good even in the absence of specific treatment.In this study, we describe three families with adFNDI, in which growth failure was a prominent complaint, on the clinical and molecular level.Design/methodsHistories from affected and unaffected family members were taken. Height and weight of index patients were recorded longitudinally. Patients underwent water deprivation tests, magnetic resonance imaging, and genetic analysis. One mutant was studied by heterologous expression in cell culture.ResultsA total of ten affected individuals were studied. In two of the three pedigrees, a novel mutation in the AVP-NPII gene was found. The index children in each pedigree showed growth retardation, which was the reason for referral in two. In these cases, water intake was tightly restricted by the parents in an attempt to overcome suspected psychogenic polydipsia and to improve appetite. Once the children were treated by hormone replacement, they rapidly caught up to normal weight and height.ConclusionsGenetic testing and appropriate parent counseling should be enforced in adFNDI families to ensure adequate treatment and avoid chronic water deprivation, which causes failure to thrive.
Thyroid autoimmunity and ophthalmopathy related to melanoma biological therapy
Authors: Min Le , Vaidya Anand , Becker Carolyn 
Published: November 2010

ObjectiveIpilimumab is a fully human MAB against cytotoxic T-lymphocyte antigen 4 (CTLA4). CTLA4 negatively regulates immune cell activation. In patients with metastatic melanoma, ipilimumab increases survival time and induces complete remission in some patients. However, immune-related adverse events including endocrinopathies have been reported. Bevacizumab, an angiogenesis inhibitor, has been used in combination with ipilimumab in patients with advanced melanoma.Patients and MethodsIn this study, we report three patients who received ipilimumab alone or combined with bevacizumab therapy and developed thyroiditis, and the first report of euthyroid Graves' ophthalmopathy.ResultsCase 1 is a 51-year-old female who presented with severe eye pain, proptosis, and periorbital edema. Laboratory results revealed normal TSH, elevated thyroid antibodies but low titer of anti-TSH receptor antibody. Imaging was consistent with Graves' ophthalmopathy. Cases 2 and 3 were referred for hyperthyroidism, and workup revealed thyroiditis. These three cases suggest that patients with advanced melanoma treated with ipilimumab +/− bevacizumab may be susceptible to a variety of thyroid disorders.ConclusionsAnti-CTLA4 therapy has shown promising results in treating advanced malignancy such as melanoma and renal carcinoma. A number of endocrinopathies, including thyroid disorders, may develop during ipilimumab therapy. The association of bevacizumab with endocrinopathies is not clear, although a few reports suggest a link to hypothyroidism. All patients on ipilimumab and/or bevacizumab therapy should be monitored for signs or symptoms of thyroiditis.
Spatial Access to Syringe Exchange Programs and Pharmacies Selling Over-the-Counter Syringes as Predictors of Drug Injectors' Use of Sterile Syringes
Authors: Cooper Hannah L. F. , Des Jarlais Don C. , Ross Zev , Tempalski Barbara , Bossak Brian , Friedman Samuel R. 
Published: November 2010

Objectives. We examined relationships of spatial access to syringe exchange programs (SEPs) and pharmacies selling over-the-counter (OTC) syringes with New York City drug injectors’ harm reduction practices. Methods. Each year from 1995 to 2006, we measured the percentage of 42 city health districts’ surface area that was within 1 mile of an SEP or OTC pharmacy. We applied hierarchical generalized linear models to investigate relationships between these exposures and the odds that injectors (n = 4003) used a sterile syringe for at least 75% of injections in the past 6 months. Results. A 1-unit increase in the natural log of the percentage of a district's surface area within a mile of an SEP in 1995 was associated with a 26% increase in the odds of injecting with a sterile syringe; a 1-unit increase in this exposure over time increased these odds 23%. A 1-unit increase in the natural log of OTC pharmacy access improved these odds 15%. Conclusions. Greater spatial access to SEPs and OTC pharmacies improved injectors’ capacity to engage in harm reduction practices that reduce HIV and HCV transmission.
Potentially Modifiable Factors Affecting the Progression of Autosomal Dominant Polycystic Kidney Disease
Authors: Torres Vicente E. , Grantham Jared J. , Chapman Arlene B. , Mrug Michal , Bae Kyongtae T. , King Bernard F. , Wetzel Louis H. , Martin Diego , Lockhart Mark E. , Bennett William M. , Moxey-Mims Marva , Abebe Kaleab Z. , Lin Yan , Bost James E. 
Published: November 2010

Summary

Background and objectives
The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) was created to identify markers of disease progression in patients with autosomal dominant polycystic kidney disease (ADPKD).

Design, setting, participants, & measurements
Linear mixed models were utilized to model effects of baseline parameters on changes in natural-log (ln)-transformed total kidney volume (TKV) and iothalamate clearance (GFR) across time in CRISP participants (creatinine clearance at entry >70 ml/min). Stepwise selection was used to obtain a final main effect model.

Results
TKV increased from year to year, whereas GFR uncorrected for body surface area (BSA) decreased only at year 6. Higher lnTKV and urine sodium excretion (UNaV), lower serum HDL-cholesterol, and younger age at baseline associated with greater lnTKV growth from baseline to year 3 and to year 6. Higher lnTKV at baseline associated with greater GFR decline from year 1 to year 3 and to year 6. Higher BSA and 24-hour urine osmolality at baseline associated with greater GFR decline from year 1 to year 6. Higher UNaV and lower serum HDL-cholesterol at baseline associated with greater GFR decline from year 1 to year 6 by univariate analysis only. Associations seen during year 1 to year 6 (not seen during year 1 to year 3) reflect the time lag between structural and functional disease progression.

Conclusions
Serum HDL-cholesterol, UNaV, and 24-hour urine osmolality likely affect ADPKD progression. To what extent their modification may influence the clinical course of ADPKD remains to be determined.
Folic Acid Therapy and Cardiovascular Disease in ESRD or Advanced Chronic Kidney Disease
Authors: Qin Xianhui , Huo Yong , Langman Craig B. , Hou Fanfan , Chen Yundai , Matossian Debora , Xu Xiping , Wang Xiaobin 
Published: November 2010

Summary

Background and objectives
The efficacy of folic acid therapy to lower homocysteine (Hcy) levels in an effort to reduce cardiovascular disease (CVD) risk in patients with ESRD or advanced chronic kidney disease (ACKD; creatinine clearance, <30 ml/min) remains inconclusive. We conducted a meta-analysis of relevant randomized trials to further examine this issue.

Design, setting, participants, & measurements
This meta-analysis included 3886 patients with ESRD/ACKD from seven qualified randomized trials using folic acid therapy and with CVD reported as one of the end points.

Results
When pooling the seven trials, folic acid therapy reduced the risk of CVD by 15% (RR, 0.85; 95% CI, 0.76 to 0.96; P = 0.009). A greater beneficial effect was observed among those trials with a treatment duration >24 months (RR, 0.84; 95% CI, 0.72 to 0.98; P = 0.02), a decrease in Hcy level >20% (RR, 0.83; 95% CI, 0.73 to 0.95; P = 0.007), and no or partial folic acid fortification (RR, 0.80; 95% CI, 0.65 to 0.99; P = 0.04). The beneficial effect also was seen when Hcy levels decreased >20%, even in the presence of folic acid fortification (RR, 0.85; 95% CI, 0.73 to 0.99; P = 0.04). In the corresponding comparison groups, the estimated RRs were attenuated and insignificant.

Conclusions
Folic acid therapy can reduce CVD risk in patients with ESRD/ACKD by 15%. A greater beneficial effect was observed among those trials with no or partial folic acid fortification or a decrease in Hcy level >20% regardless of folic acid fortification.
Decreased Cumulative Access Survival in Arteriovenous Fistulas Requiring Interventions to Promote Maturation
Authors: Lee Timmy , Ullah Ahsan , Allon Michael , Succop Paul , El-Khatib Mahmoud , Munda Rino , Roy-Chaudhury Prabir 
Published: November 2010

Summary

Background and objectives
New arteriovenous fistulas (AVF) are frequently unsuitable for hemodialysis because of AVF nonmaturation. Aggressive endovascular or surgical interventions are often undertaken to salvage nonmaturing AVFs. The effect of early interventions to promote AVF maturation on subsequent long-term AVF outcomes is unknown.

Design, setting, participants, & measurements
We evaluated 173 hemodialysis patients from two academic centers who received a new AVF. Of these, 96 (56%) required no further intervention, 54 (31%) required one intervention, and 23 (13%) required two or more interventions to achieve suitability for dialysis. We calculated AVF survival and frequency of postmaturation interventions in each group.

Results
Cumulative AVF survival (access cannulation to permanent failure) in patients with two or more versus one versus zero interventions before maturation was 68% versus 78% versus 92% at 1 year, 57% versus 71% versus 85% at 2 years, and 42% versus 57% versus 75% at 3 years. Using Cox regression analysis with interventions before maturation, age, sex, race, diabetes, peripheral vascular disease, access site, and obesity in the model, intervention before maturation (two or more) was the only factor associated with cumulative AVF survival. The number of interventions required to maintain patency after maturation was 3.51 ± 2.20 versus 1.37 ± 0.31 versus 0.76 ± 0.10 per year in patients with two or more versus one versus zero interventions before maturation.

Conclusions
Compared with AVF that mature without interventions, AVF that require interventions have decreased cumulative survival and require more interventions to maintain their patency for hemodialysis.
Boxing Training for Patients With Parkinson Disease: A Case Series
Authors: Combs Stephanie A. , Diehl M. Dyer , Staples William H. , Conn Lindsay , Davis Kendra , Lewis Nicole , Schaneman Katie 
Published: November 2010

Background and PurposeA nontraditional form of exercise recently applied for patients with Parkinson disease (PD) is boxing training. The primary purpose of this case series is to describe the effects of disease severity and duration of boxing training (short term and long term) on changes in balance, mobility, and quality of life for patients with mild or moderate to severe PD. The feasibility and safety of the boxing training program also were assessed.Case DescriptionsSix patients with idiopathic PD attended 24 to 36 boxing training sessions for 12 weeks, with the option of continuing the training for an additional 24 weeks (a seventh patient attended sessions for only 4 weeks). The 90-minute sessions included boxing drills and traditional stretching, strengthening, and endurance exercises. Outcomes were tested at the baseline and after 12, 24, and 36 weeks of boxing sessions (12-, 24-, and 36-week tests). The outcome measures were the Functional Reach Test, Berg Balance Scale, Activities-specific Balance Confidence Scale, Timed “Up & Go” Test, Six-Minute Walk Test, gait speed, cadence, stride length, step width, activities of daily living and motor examination subscales of the Unified Parkinson Disease Rating Scale, and Parkinson Disease Quality of Life Scale.OutcomesSix patients completed all phases of the case series, showed improvements on at least 5 of the 12 outcome measures over the baseline at the 12-week test, and showed continued improvements at the 24- and 36-week tests. Patients with mild PD typically showed improvements earlier than those with moderate to severe PD.DiscussionDespite the progressive nature of PD, the patients in this case series showed short-term and long-term improvements in balance, gait, activities of daily living, and quality of life after the boxing training program. A longer duration of training was necessary for patients with moderate to severe PD to show maximal training outcomes. The boxing training program was feasible and safe for these patients with PD.
Your Pillow May Not Guarantee a Good Night's Sleep or Symptom-Free Waking
Authors: Gordon Susan J. , Grimmer-Somers Karen 
Published: November 2010

Purpose: To describe the performance of the pillow that participants usually slept on with respect to retiring and waking cervico-thoracic symptoms, pillow comfort, and sleep quality. Methods: Participants (n=106) were systematically recruited for a field trial comparing their own pillow and five trial pillows. Participants provided daily retiring and waking symptom reports and sleep-quality and pillow-comfort ratings prospectively for 1 week on each pillow. Linear and logistic regression models were used to investigate the relationship between pillow use, age, gender, sleep quality, pillow comfort, and waking and temporal (overnight) symptom reports. Results: No waking symptoms were reported by 42.5% of participants on their own pillow. Regular waking symptoms, failure to relieve retiring symptoms, uncomfortable pillows, and/or poor-quality sleep were reported by over 50% of participants. All participants who reported poor sleep quality also reported poor pillow comfort. Pillow-comfort reports were not related to any waking symptom report; however, reports of poor sleep quality were significantly related to waking cervical stiffness (adjusted odds ratio [AOR]=4.3 [Confidence Interval (CI): 1.3–15.6]) and scapula pain (AOR=6.1 [CI: 1.1–31.6]). Feather pillow users provided consistently low reports of pillow comfort and sleep quality. Conclusion: Many participants appear to have made poor pillow choices, as poor sleep quality, low pillow comfort, and waking symptoms were common. Further research is required to understand why people choose particular pillows to sleep on, as well as to identify the best fit between person and pillow to optimize sleep quality and reduce waking symptoms.
“Sermons are dangerous things”: George Herbert, Richard Bernard, and the Politics of Preaching
Authors: Bell Susan J.A. 
Published: November 2010

Abstract: In early Stuart England the office and content of preaching were both important and controversial matters. In this time of the continuing reformation of the pastoral office, two manuals for pastors illustrate the ecclesiastical tension: George Herbert's Countrey Parson and Richard Bernard's Faithfull Shepheard. While the Calvinist Bernard and the conforming Herbert were both moderates and though their manuals show significant overlap, a comparison between the two works shows that Herbert developed a new and holistic understanding of the preaching office. Within his larger project of defending the English priesthood as a worthy profession, he situates the importance of the preached Word within the totality of the parson's ministerial duties. Moreover, the whole of pastoral presence and practice are seen as expressions of “sermon” and extensions of the preaching vocation.
Reformed Preaching and the Conundrum of Calvin's Example
Authors: Wilson Paul Scott 
Published: November 2010

Abstract: Reformed preaching is grounded in understandings of the nature and purpose of the Word of God found in various confessions and catechisms. Some of the reformers' hermeneutical practices continued Roman Catholic practice and some contrasted it. They had clearer understandings than are common today on the role of the Spirit in interpretation, the role of the hearers, and the purpose of preaching as salvation. Concerning the last, Calvin is particularly helpful: preaching is to present Jesus Christ and the centrality of the gospel, preaching is a sacrament, and preaching is inspired doctrine. His third and principal use of the law is essentially gospel. However, his sermons give a conflicting message, for Jesus Christ and the gospel are largely absent, and law and Christian duty seem foremost. Suggestions are offered to account for these differences and for preachers to benefit from the Reformed heritage.
Biblical Faith and Paths of Peace
Authors: Vennen Mark Vander 
Published: November 2010

Abstract: As well as providing statistics and information about current military conflict and inhumane weaponry, this article brings a biblical perspective to bear on the contemporary realities of peace and conflict. In the face of the most violent century on record (the twentieth century) and the unrelenting advancement of contemporary military technological development, the author argues that it is a mistake to privilege the narrow just war / pacifist polarity. In using it as the interpretive framework for understanding the multifaceted issues of human conflict, we tend to subvert a larger and more constructive engagement with the challenge of armed conflict and its resolution. Calvin's unremarkable adherence to the just war theory does not offer a contribution to contemporary peace-building. However, his anthropology, rooted in the positioning of humanity in relationship to the living God, can provide a theological undergirding for current peace-building approaches, including in the current conflict in Afghanistan.
Endoscopic third ventriculostomy in adults: a technique for dealing with the neural (opaque) floor
Authors: Grand Walter , Leonardo Jody 
Published: November 2010

Object
An opaque (neural) floor of the third ventricle is considered an obstacle to safe penetration of the floor of the third ventricle in endoscopic third ventriculostomy (ETV). The direct technique of endoscopic coring (“cookie cut”) of the opaque (neural) floor of the third ventricle is described in 41 cases among a total of 101 consecutive adult ETVs.

Methods
A 0° endoscope in a 4.6-mm irrigating sheath was used to press and core (“cookie cut”) a section of the tuber cinereum, thereby exposing the underlying membranes and vasculature. Thereafter, the endoscopic apparatus was used to penetrate the membrane into the prepontine space.

Results
Among 101 consecutive ETVs performed in adults, there were 41 instances of an opaque floor in which the coring technique was used. The basilar artery (BA) complex was in the intended path of penetration in 13 cases. There were no perioperative deaths or vascular injuries. No cases were aborted because of the opaque floor or the configuration of the BA complex. The clinical success rate in the opaque floor group was 80% (33 of 41 patients).

Conclusions
An opaque (neural) floor is frequently seen in adults during ETV. Removing the floor by the core (“cookie cut”) method is a safe means of revealing the underlying BA complex and membranous structures prior to penetration into the prepontine cistern. On occasion, the BA complex may be in the path of penetration, and one can maneuver the endoscope to displace the vasculature to successfully accomplish the ETV.
Comportements oraux et intériorisés dans le déchiffrage des syllabes au début de l'apprentissage de la lecture.
Authors: Leroy-Boussion A. 
Published: November 2010

Oral and inner behaviour in syllabes decoding at the begining of learning to read -
Purpose : The young child, when he begins to learn to read, and when he tries to decode syllabes has a propensity to decompose verbaly the two terms of that syllabes. He first expresses aloud the sound /p/, then sound /a/, before expressing the syllabe-sound « pa ». This need of vocal extériorisation disappears progressively with age and school training. — Technique : We have studied by longitudinal method the regression of this exteriorised behaviour (continuous observation of 179 normal scholl children) during three consecutive years, from five to eight years old. This study has been done taking into account mental maturity level (Q.I.) and considering the different types of exteriorised behaviour : loud voice and intermediate behaviour (i. e. whispers, articulate motions of lips, quivering of lips). — Results : Perfect intériorisation (reading « at once » of syllabes without decomposition, without vocalization and without motions of mouth is reached at age of 7 years 1 month for forward children (Q.I. 139-110), ot 7 years 7 months for normal children (Q.I. 109-90) ; it is not yet reached for retarded children (Q.I. 89-70) at the end of our observation period. When children become older, the « intermediate » behaviour tends to remplace the loud voice behaviour.
Facilitation et freinage dans le travail scolaire.
Authors: Rousson Michel 
Published: November 2010

Les élèves de 12 classes neuchâteloises ont complété trois phrases destinées à mesurer l'influence de l'environnement scolaire sur leurs attitudes à l'égard du travail.
Il apparaît que les éléments de freinage et de facilitation sont les mêmes pour toutes les catégories d'élèves (sexes, niveaux socio-économiques, « sur-réalisateurs » et « sous-réalisateurs »). En revanche, la « nature du travail » et les « barrières » (interrogation attendue par exemple) jouent un rôle dans l'effort que fait le sujet. De plus toute punition, blâme ou mauvaise note ainsi qu'un environnement physique difficile découragent l'élève.
Sur les notions d'enfance et de changement dans le débat entre rationalistes et empiristes.
Authors: Netchine Serge 
Published: November 2010

Les thèmes du changement à long terme (enfance, développement) et à moyen ou à court terme (association d'idées, apprentissages, formation d'habitudes, dépassement des habitudes inadaptatives) sont utilisés quasi indifféremment dans les débats entre philosophes rationalistes et empiristes à l'âge classique.
Les psychologues reprennent ces thèmes tout en les différenciant et en les séparant pour des raisons méthodologiques. Mais ils tendent actuellement à les réunir à nouveau pour apporter une réponse aux questions soulevées dans chacun des deux secteurs.