bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Highly Enantioselective Amination Reactions of Fluorinated Keto Esters Catalyzed by Novel Chiral Guanidines Derived from Cinchona Alkaloids.
Authors: Han Xiao , Zhong Fangrui , Lu Yixin 
Published: February 2011

AbstractThe new CAG catalyzes direct stereoselective amination of fluorinated keto esters to give products with fluorine‐containing quaternary stereogenic centers.
ChemInform Abstract: Formation of Multi‐Stereogenic Centers Using a Catalytic Diastereoselective Henry Reaction.
Authors: Arai Takayoshi , Taneda Yoshinori , Endo Yoko 
Published: February 2011

AbstractA diastereomeric Henry reaction of enantiopure aldehydes (V) is developed using a chiral sulfonyl diamine/CuCl complex as catalyst.
ChemInform Abstract: Chemoselective Deprotection of Silyl Ethers by DIBALH.
Authors: Kuranaga Takefumi , Ishihara Shuji , Ohtani Naohito , Satake Masayuki , Tachibana Kazuo 
Published: February 2011

AbstractThe highly selective procedure allows to remove primary silyl ethers in the presence of a secondary Tes group.
ChemInform Abstract: A Three‐Component One‐Pot Synthesis of Functionalized 5,5‐Dicyanocyclopenta‐1,3‐dienes from Arylidenemalononitriles, Activated Acetylenes, and KCN or KSCN.
Authors: Yavari Issa , Sirouspour Mehdi , Souri Sanaz 
Published: February 2011

AbstractReaction of arylidenemalononitriles with the esters (II) and thiocyanate as anionic nucleophile results in formation of thiophene derivatives (III) as major products.
ChemInform Abstract: Ruthenium(II)‐Catalyzed Asymmetric Transfer Hydrogenation of Aromatic Ketones in Water Using Novel Water‐Soluble Chiral Monosulfonamide Ligands.
Authors: Zhou Zhongqiang , Ma Qiong , Sun Yong , Zhang Aiqing , Li Lin 
Published: February 2011

AbstractA series of ligands of type (I) and (II) is synthesized.
ChemInform Abstract: Ligand‐Free Palladium‐Catalyzed C—S Coupling Reactions Using Water as Solvent and Microwaves.
Authors: Velmathi Sivan , Vijayaraghavan Reena , Amarendar Ch. , Pal Ravindra P. , Vinu Ajayan 
Published: February 2011

AbstractThe synthesis of various aryl sulfides becomes possible by direct Pd‐catalyzed microwave‐promoted substitution of thiols with aryl halides.
ChemInform Abstract: Palladium on Charcoal‐Catalyzed Ligand‐Free Stille Coupling.
Authors: Yabe Yuki , Maegawa Tomohiro , Monguchi Yasunari , Sajiki Hironao 
Published: February 2011

AbstractProtocols are developed for the ligand‐ and copper‐free heterogeneous process under non‐inert conditions.
ChemInform Abstract: Palladium Nanoparticles in Ionic Liquid by Sputter Deposition as Catalysts for Suzuki—Miyaura Coupling in Water.
Authors: Oda Yoshiri , Hirano Koji , Yoshii Kazuki , Kuwabata Susumu , Torimoto Tsukasa , Miura Masahiro 
Published: February 2011

AbstractThe title system efficiently catalyzes the coupling of hydrophobic as well as hydrophilic aryl halides (I) in water.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Coupling of Benzyl Chlorides with Aryl Boronic Acids in Aqueous Media.
Authors: Wu Xiao‐Feng , Neumann Helfried , Beller Matthias 
Published: February 2011

AbstractThe new procedure is carried out at low CO pressure to afford 1,3‐diarylethanones as important synthons.
ChemInform Abstract: Synthesis of New Bimetallic Chiral Salen Catalyst Bearing Co(BF4)2 Salt and Its Application in Asymmetric Ring Opening of Epoxide.
Authors: Kim Yong‐Suk , Lee Choong‐Young , Kim Geon‐Joong 
Published: February 2011

AbstractA new bimetallic chiral salen catalyst containing the Co(BF4)2 moiety is non‐covalently anchored on the acidic sites of mesoporous Al‐SBA‐15 and used for the asymmetric ring opening of epoxides.
ChemInform Abstract: A New Approach to Desketoraloxifene Analogues from Oxygen‐Bearing 3‐Iodobenzo[b]thiophenes Prepared via Iodocyclization.
Authors: Cho Chul‐Hee , Jung Dai‐Il , Larock Richard C. 
Published: February 2011

AbstractIn continuation of efforts to develop novel selective estrogen receptor modulators with antagonist properties against breast cancer, the synthesis of desketoraloxifene (VI) and analogues (V) is described.
ChemInform Abstract: Azirine Ligation: Fast and Selective Protein Conjugation via Photoinduced Azirine—Alkene Cycloaddition.
Authors: Lim Reyna K. V. , Lin Qing 
Published: February 2011

AbstractA novel bioorthogonal ligation reaction between azirine (Ib) and dimethyl fumarate (II) is described.
ChemInform Abstract: Gold(I)/Zn(II) Catalyzed Tandem Hydroamination/Annulation Reaction of 4‐Yne‐nitriles.
Authors: Demir Ayhan S. , Emrullahoglu Mustafa , Buran Kerem 
Published: February 2011

AbstractThe title reaction affords two regioisomeric 2‐aminopyrroles (III) and (IV) in moderate to good yields.
ChemInform Abstract: Bicyclic Guanidine‐Catalyzed Direct Asymmetric Allylic Addition of N‐Aryl Alkylidene‐Succinimides.
Authors: Wang Jianmin , Liu Hongjun , Fan Yitian , Yang Yuanyong , Jiang Zhiyong , Tan Choon‐Hong 
Published: February 2011

AbstractThe title reaction affords aza‐heterocycles with multiple chiral centers.
ChemInform Abstract: Synthesis and Antiparkinsonian Activity of Some New Adamantyl Thiazolidinonyl/Azetidinonyl Indole Derivatives.
Authors: Kumar Sunil , Kaur Hemlata , Saxena K. K. , Sharma Monica , Vishwakarma Pinki , Kumar Ashok 
Published: February 2011

AbstractThe results of antiparkinsonian activity are different for the tested compounds.
ChemInform Abstract: Highly Organocatalytic Asymmetric Michael—Ketone Aldol—Dehydration Domino Reaction: Straightforward Approach to Construct Six‐Membered Spirocyclic Oxindoles.
Authors: Wang Liang‐Liang , Peng Lin , Bai Jian‐Fei , Huang Qing‐Chun , Xu Xiao‐Ying , Wang Li‐Xin 
Published: February 2011

AbstractThe title reaction affords six‐membered spirocyclic oxindoles (III), bearing contiguous stereogenic centers in high yields and excellent dia‐ and enantioselectivities.
ChemInform Abstract: Cyclization of Zincated α‐N‐Homoallylamino Nitriles: A New Entry to Enantiopure 2,3‐Methanopyrrolidines.
Authors: Ouizem Sabrina , Cheramy Sandrine , Botuha Candice , Chemla Fabrice , Ferreira Franck , Perez‐Luna Alejandro 
Published: February 2011

AbstractA new stereoselective cyclization that provides enantiopure 2,3‐methanopyrrolidines from zincated α‐N‐homoallylamino nitriles occurs with a stereospecific inversion of the homoallylic stereogenic center.
ChemInform Abstract: Direct, Catalytic Synthesis of Carbapenams via Cycloaddition/Rearrangement Cascade Reaction: Unexpected Acetylenes′ Structure Effect.
Authors: Mames Adam , Stecko Sebastian , Mikolajczyk Paulina , Soluch Magdalena , Furman Bartlomiej , Chmielewski Marek 
Published: February 2011

AbstractThe CuI‐mediated treatment of the nitrones (I) and (VI) with acetylenes is found to provide carbapenams with high stereoselectivity.
ChemInform Abstract: Asymmetric 1,3‐Dipolar Cycloaddition of Azomethine Imines to Homoallylic Alcohols.
Authors: Tanaka Katsuyoshi , Kato Tomomitsu , Fujinami Shuhei , Ukaji Yutaka , Inomata Katsuhiko 
Published: February 2011

AbstractThe title reaction is achieved by utilizing diisopropyl (R,R)‐tartrate as a chiral auxiliary to give the corresponding optically active trans‐pyrazolines (III) with high regio‐, diastereo‐, and enantioselectivities.
ChemInform Abstract: In situ Coupled Oxidation Cycle Catalyzed by Highly Active and Reusable Pt‐Catalysts: Dehydrogenative Oxidation Reactions in the Presence of a Catalytic Amount of o‐Chloranil Using Molecular Oxygen as the Terminal Oxidant.
Authors: Miyamura Hiroyuki , Maehata Kanako , Kobayashi Shu 
Published: February 2011

AbstractAn in situ coupled oxidation cycle is developed and applied to dihydropyridines (I) and (III), indoline (V), and 4‐methoxybenzylether (VII).
ChemInform Abstract: Trimethylsilyl Iodide Promoted Aza‐Prins Cyclization for the Synthesis of 4‐Iodopiperidines.
Authors: Sabitha Gowravaram , Das Sukant Kishore , Srinivas Rangavajjula , Yadav Jhillu S. 
Published: February 2011

AbstractHomoallyl‐N‐tosylamine (I) reacts with aliphatic aldehydes to produce the title compounds with high trans‐selectivity.
ChemInform Abstract: Formation of 1,2‐Dihydroquinoline‐3‐carboxylic Acid Derivatives from Methyl 3‐(Arylamino)acrylates with Hydrogen Iodide.
Authors: Matsumoto Shoji , Mori Takahiro , Akazome Motohiro 
Published: February 2011

AbstractThe reaction of methyl (arylamino)acrylates with hydrogen iodide proceeds efficiently in an alcoholic solvent bearing a bulky alkyl substituent to provide the corresponding title derivatives.
ChemInform Abstract: Rh(I)‐Catalyzed Direct Arylation of Azines.
Authors: Berman Ashley M. , Bergman Robert G. , Ellman Jonathan A. 
Published: February 2011

AbstractIn the presence of Rh2Cl2(CO)4, quinolines and 2‐substituted azines efficiently react with a number of aryl bromides and aroyl chlorides to afford ortho‐arylated products.
ChemInform Abstract: Short and Efficient Access to Imidazo[1,2‐a]pyrrolo[3,2‐c]pyridine Derivatives.
Authors: Caumet Vincent , et al. et al. 
Published: February 2011

AbstractStraightforward strategies are presented for the preparation of the title compounds (VII) by catalytic coupling of 8‐halo derivatives with terminal alkynes followed by Pd‐ or Cu‐catalyzed ring closure.
ChemInform Abstract: Cascade Cyclization of 3(5)‐Aminopyrazoles with Aromatic Aldehydes and Cyclohexanediones.
Authors: Lipson V. V. , Svetlichnaya N. V. , Borodina V. V. , Shirobokova M. G. , Shishkina S. V. , Shishkin O. V. , Musatov V. I. 
Published: February 2011

AbstractThe three‐component condensation of aminopyrazoles (I) with diones (II) and aryl aldehydes (III) regioselectively affords pyrazoloquinazolinones (IV), whilst the analogous reaction of aminopyrazole (V) leads to mixtures of pyrazoloquinazolinones (VI) and pyrazoloquinolinones (VII) in most cases.
ChemInform Abstract: Synthesis of 5‐Trifluoromethylpyrazol‐1‐yl‐substituted 1,2,4,5‐Tetrazines.
Authors: Tolshchina S. G. , Ignatenko N. K. , Slepukhin P. A. , Ishmetova R. I. , Rusinov G. L. 
Published: February 2011

AbstractThe title compounds are synthesized in medium to good yields and their reactivity is studied in nucleophilic substitution and [4 + 2] cycloaddition reactions.
ChemInform Abstract: Subphthalocyanines Having Axial Substituent with Direct B—C Bond: General Preparation and Physical Properties.
Authors: Yamasaki Yasuhiro , Mori Tomohiro 
Published: February 2011

AbstractCoupling of the haloboron subphthalocyanine (I) with Grignard reagents affords title compounds of type (III) bearing an axial substituent at the boron—carbon direct bond.
ChemInform Abstract: Intramolecular Cyclization of N‐Hetarylphosphinimidic Isocyanates in the Synthesis of 1,7‐Dihydro‐4H‐imidazo[4,5‐d][1,3,2]diazaphosphinin‐4‐one (2‐Phosphapurine).
Authors: Marchenko Anatoliy P. , Koydan Georgiy K. , Huryeva Anastasia S. , Smaliy Radomyr V. , Yurchenko Aleksandr A. , Alekseenko Anatoliy N. 
Published: February 2011

AbstractThe synthesis of previously unknown target compounds (V) and (VII) containing an endocyclic P=N double bond is reported.
ChemInform Abstract: Synthesis of New Types of N,N‐Disubstituted Aminomethylspirophosphoranes.
Authors: Prishchenko Andrey A. , Livantsov Mikhail V. , Novikova Olga P. , Livantsova Ludmila I. , Petrosyan Valery S. 
Published: February 2011

AbstractThe diaminoalkylation of hydrospirophosphoranes (I) is studied and the underlying mechanisms are discussed.
ChemInform Abstract: A New Rhodamine B Derivative as a Colorimetirc Chemosensor for Recognition of Copper(II) Ion.
Authors: Tang Lijun , Li Fangfang , Liu Minghui , Nandhakumar Raju 
Published: February 2011

AbstractThe new chemosensor (I) shows a high selectivity towards Cu2+ and it can be also used at neutral conditions (pH 7).
ChemInform Abstract: Iridoid and Acyclic Monoterpene Glycosides, Kankanosides L, M, N, O, and P from Cistanche tubulosa.
Authors: Morikawa Toshio , Pan Yingni , Ninomiya Kiyofumi , Imura Katsuya , Yuan Dan , Yoshikawa Masayuki , Hayakawa Takao , Muraoka Osamu 
Published: February 2011

AbstractThree iridoid glycosides, kankanosides L (I), M (II), and N (III), and two acyclic monoterpene glycosides, kankanosides O (IV) and P (V), are isolated from fresh stems of Cistanche tubulosa (Orobanchaceae) together with a multiplicity of known glycosides.
ChemInform Abstract: A Highly Efficient Synthesis of Telaprevir by Strategic Use of Biocatalysis and Multicomponent Reactions.
Authors: Znabet Anass , Polak Marloes M. , Janssen Elwin , de Kanter Frans J. J. , Turner Nicholas J. , Orru Romano V. A. , Ruijter Eelco 
Published: February 2011

AbstractA short and efficient synthesis of the important drug candidate telaprevir (IX), featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps is presented.
ChemInform Abstract: Two New Microcyclamides from a Water Bloom of the Cyanobacterium Microcystis sp.
Authors: Zafrir‐Ilan Ella , Carmeli Shmuel 
Published: February 2011

AbstractMicrocyclamide MZ602 (Ia) and MZ568 (Ib) are tested for their cytotoxicity against leukemia cells and their inhibition of serine proteases.
ChemInform Abstract: Fluoroglycoproteins: Ready Chemical Site‐Selective Incorporation of Fluorosugars into Proteins.
Authors: Boutureira Omar Boutureira Omar , D'Hooge Francois , Fernandez‐Gonzalez Marta , Bernardes Concalo J. L. , Sanchez‐Navarro Macarena , Koeppe Julia R. , Davis Benjamin G. 
Published: February 2011

AbstractA tag‐and‐modify strategy for the synthesis of homogenous fluorinated glyco‐amino acids, peptides, and proteins carrying fluorine labels in the sugar moiety is described, allowing, for example, access to directly radiolabelled 18F‐glycoproteins.
ChemInform Abstract: A Novel Bridged Nucleoside Bearing a Conformationally Switchable Sugar Moiety in Response to Redox Changes.
Authors: Baba Takeshi , Kodama Tetsuya , Mori Kazuto , Imanishi Takeshi , Obika Satoshi 
Published: February 2011

AbstractA novel nucleoside analogue (IV) with a disulfide bridge structure at the sugar moiety, which shows redox‐responsive reversibility of the sugar conformation due to the formation and scission of the disulfide bond, is designed and synthesized.
ChemInform Abstract: Application of Copper(I)‐Catalyzed Azide/Alkyne Cycloaddition (CuAAC) “Click Chemistry” in Carbohydrate Drug and Neoglycopolymer Synthesis
Authors: Aragao‐Leoneti Valquiria , Campo Vanessa L. , Gomes Adriane S. , Field Robert A. , Carvalho Ivone 
Published: February 2011

AbstractReview: 103 refs.
ChemInform Abstract: Benzimidazole in Medicinal Chemistry: An Overview
Authors: Kedar Manisha S. , Dighe Nachiket S. , Pattan Shashikant R. , Musmade Deepak S. , Thakur Dipak , Bhosale Mayur , Gaware Vinayak M. 
Published: February 2011

AbstractReview: 25 refs.
Cotton Fiber/ZrO2, A New Material for Adsorption of Cr(VI) Ions in Water
Authors: Muxel Alfredo Alberto , Gimenez Sonia Maria Nobre , de Souza Almeida Flaveli Aparecida , da Silva Alfaya Rení Ventura , da Silva Alfaya Antonio Alberto 
Published: February 2011

AbstractThe natural cotton fiber was used to synthesize an anion exchange, containing ZrO2 film on its surface, NCFZC (natural cotton fiber/ZrO2 composite). This anion exchanger was produced by the reaction of the zirconium oxychloride and hydroxyl groups on surface of the natural cotton fiber. The material was used for Cr(VI) ions adsorption studies. Adsorption equilibrium time and optimum pH for Cr(VI) adsorption were found to be 6 h and 4.0, respectively. The Langmuir and Temkin isotherms were used to models adsorption equilibrium data. The adsorption capacity of NCFZC was found to be 1.33 mmol/g. Kinetic studies showed that the rate of adsorption of Cr(VI) on NCFZC obeyed a pseudo‐second‐order kinetic model.
Disordered eating and religious observance: A focus on ultra‐orthodox Jews in an adult community study
Authors: Feinson Marjorie C. , Meir Adi 
Published: February 2011

AbstractObjective:To broaden the socio‐cultural context of eating disturbances by exploring religious observance and its presumed protective role for ultra‐Orthodox women.Method:Detailed telephone interviews with community sample of adult Jewish women in Israel, including 261 ultra‐Orthodox. Frequency of 14 symptoms of disordered eating (DEB) assessed. Hierarchical regressions examine predictors of DEB severity within observance categories (ultra‐Orthodox, Orthodox, Traditional, and Secular).Results:Contrary to expectations, no significant differences were found in the frequency of serious DEB between the most and least religiously observant, ultra‐Orthodox, and Secular women. Regressions reveal similar predictors of DEB severity (obesity followed by self‐criticism) as well as substantial variations in amount of variance explained.Discussion:Apparently, rigorous religious adherence does not protect ultra‐Orthodox women from serious eating problems. Additional analyses can inform socio‐cultural perspectives by examining the connection between body dissatisfaction and disordered eating in this insular and isolated religious community, whose exposure to secular media is prohibited. © 2011 by Wiley Periodicals,Inc. (Int J Eat Disord 2012)
High‐sensitivity detection using isotachophoresis with variable cross‐section geometry
Authors: Bahga Supreet S. , Kaigala Govind V. , Bercovici Moran , Santiago Juan. G. 
Published: February 2011

AbstractWe present a theoretical and experimental study on increasing the sensitivity of ITP assays by varying channel cross‐section. We present a simple, unsteady, diffusion‐free model for plateau mode ITP in channels with axially varying cross‐section. Our model takes into account detailed chemical equilibrium calculations and handles arbitrary variations in channel cross‐section. We have validated our model with numerical simulations of a more comprehensive model of ITP. We show that using strongly convergent channels can lead to a large increase in sensitivity and simultaneous reduction in assay time, compared to uniform cross‐section channels. We have validated our theoretical predictions with detailed experiments by varying channel geometry and analyte concentrations. We show the effectiveness of using strongly convergent channels by demonstrating indirect fluorescence detection with a sensitivity of 100 nM. We also present simple analytical relations for dependence of zone length and assay time on geometric parameters of strongly convergent channels. Our theoretical analysis and experimental validations provide useful guidelines on optimizing chip geometry for maximum sensitivity under constraints of required assay time, chip area and power supply.
10 000‐fold concentration increase in proteins in a cascade microchip using anionic ITP by a 3‐D numerical simulation with experimental results
Authors: Bottenus Danny , Jubery Talukder Zaki , Dutta Prashanta , Ivory Cornelius F. 
Published: February 2011

AbstractThis paper describes both the experimental application and 3‐D numerical simulation of isotachophoresis (ITP) in a 3.2 cm long “cascade” poly(methyl methacrylate) (PMMA) microfluidic chip. The microchip includes 10× reductions in both the width and depth of the microchannel, which decreases the overall cross‐sectional area by a factor of 100 between the inlet (cathode) and outlet (anode). A 3‐D numerical simulation of ITP is outlined and is a first example of an ITP simulation in three dimensions. The 3‐D numerical simulation uses COMSOL Multiphysics v4.0a to concentrate two generic proteins and monitor protein migration through the microchannel. In performing an ITP simulation on this microchip platform, we observe an increase in concentration by over a factor of more than 10 000 due to the combination of ITP stacking and the reduction in cross‐sectional area. Two fluorescent proteins, green fluorescent protein and R‐phycoerythrin, were used to experimentally visualize ITP through the fabricated microfluidic chip. The initial concentration of each protein in the sample was 1.995 μg/mL and, after preconcentration by ITP, the final concentrations of the two fluorescent proteins were 32.57±3.63 and 22.81±4.61 mg/mL, respectively. Thus, experimentally the two fluorescent proteins were concentrated by over a factor of 10 000 and show good qualitative agreement with our simulation results.
The rising demand for consultation‐liaison psychiatry for older people: comparisons within Liverpool and the literature across time
Authors: Anderson David , Nortcliffe Margaret , Dechenne Sophie , Wilson Kenneth 
Published: February 2011

AbstractObjectivesTo compare the rate of referrals of older people for consultation‐liaison psychiatry services over time within Liverpool and with the literature.MethodsAll referrals to the liaison psychiatry service for older people in Liverpool between 1999 and 2004 were used to calculate referral rates and compared with data from the same hospital from 1981 to 1989 previously published. Data related to referral rates was extracted from other published studies to allow cross‐national comparisons over time.ResultsBetween 1999 and 2004 there were 2760 referrals to the Liverpool liaison psychiatry service for older people producing an average annual referral rate of 2.89%. This compares to a referral rate of 0.7% in 1981 and 1.34% in 1989. Comparison with studies from the UK, North America, Europe, Singapore and Taiwan shows an increasing trend across a 30 year period. The rate of referral increases with increasing age up to age 90.ConclusionTrends indicate increasing rates of referral of older people to consultation‐liaison psychiatry services with greater representation of the older old. Similar effects are likely to be experienced in all nations with an ageing population. Liaison psychiatry services will need professionals trained in old age psychiatry if the needs of this increasing elderly population are to be addressed. Copyright © 2011 John Wiley & Sons, Ltd.
Preclinical therapeutic response of residual metastatic disease is distinct from its primary tumor of origin
Authors: Day Chi‐Ping , Carter John , Bonomi Carrie , Hollingshead Melinda , Merlino Glenn 
Published: February 2011

AbstractCancer‐related deaths are caused principally by recurrence and metastasis arising from residual disease, whose therapeutic responses has been suggested to be substantially different from primary tumors. However, experimental animal models designed for evaluating the therapeutic responses of residual disease are mostly lacking. To overcome this deficiency, we have developed a preclinical model that recapitulates the progression for advanced nonsmall cell lung cancer (NSCLC). An archived Lewis lung carcinoma mouse tumor, propagated only through serial in vivo transplantation and never adapted to cell culture, was stably labeled using lentivirus‐encoded biomarkers, consistently expressed through an RNA polymerase II promoter. Labeled tumors were inoculated into syngeneic immunocompetent mice to ensure superior tumor–host interactions. Primary tumors were resected on reaching a predetermined size, followed by treatment in a setting akin to postsurgical first‐line adjuvant chemotherapy and routine imaging to monitor the progression of pulmonary metastasis. We discovered that efficacious treatment, instead of reducing disease growth rates, significantly prolonged disease‐free survival and overall survival. As in the clinic, cisplatin‐based regimes were more effective in this model. However, the response of metastases to specific agents could not be predicted from, and often opposed, their effects on subcutaneous “primary” tumors, possibly due to their distinct growth kinetics and host interactions. We here introduce a clinically relevant model of residual metastatic disease that may more accurately predict the therapeutic response of recurrent, metastatic disease.