bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupled Ocean–Atmosphere Variations over the South Atlantic Ocean
Authors: Nobre Paulo , De Almeida Roberto A. , Malagutti Marta , Giarolla Emanuel 
Published: April 2012

Abstract
The impact of ocean–atmosphere interactions on summer rainfall over the South Atlantic Ocean is explored through the use of coupled ocean–atmosphere models. The Brazilian Center for Weather Forecast and Climate Studies (CPTEC) coupled ocean–atmosphere general circulation model (CGCM) and its atmospheric general circulation model (AGCM) are used to gauge the role of coupled modes of variability of the climate system over the South Atlantic at seasonal time scales. Twenty-six years of summer [December–February (DJF)] simulations were done with the CGCM in ensemble mode and the AGCM forced with both observed sea surface temperature (SST) and SST generated by the CGCM forecasts to investigate the dynamics/thermodynamics of the two major convergence zones in the tropical Atlantic: the intertropical convergence zone (ITCZ) and the South Atlantic convergence zone (SACZ). The results present both numerical model and observational evidence supporting the hypothesis that the ITCZ is a thermally direct, SST-driven atmospheric circulation, while the SACZ is a thermally indirect atmospheric circulation controlling SST variability underneath—a consequence of ocean–atmosphere interactions not captured by the atmospheric model forced by prescribed ocean temperatures. Six CGCM model results of the Ensemble-based Predictions of Climate Changes and their Impacts (ENSEMBLES) project, NCEP–NCAR reanalysis data, and oceanic and atmospheric data from buoys of the Prediction and Research Moored Array in the Tropical Atlantic (PIRATA) Project over the tropical Atlantic are used to validate CPTEC’s coupled and uncoupled model simulations.
Projected Changes in the Seasonal Cycle of Surface Temperature
Authors: Dwyer John G. , Biasutti Michela , Sobel Adam H. 
Published: April 2012

Abstract
When forced with increasing greenhouse gases, global climate models project a delay in the phase and a reduction in the amplitude of the seasonal cycle of surface temperature, expressed as later minimum and maximum annual temperatures and greater warming in winter than in summer. Most of the global mean changes come from the high latitudes, especially over the ocean. All 24 Coupled Model Intercomparison Project phase 3 models agree on these changes and, over the twenty-first century, average a phase delay of 5 days and an amplitude decrease of 5% for the global mean ocean surface temperature. Evidence is provided that the changes are mainly driven by sea ice loss: as sea ice melts during the twenty-first century, the previously unexposed open ocean increases the effective heat capacity of the surface layer, slowing and damping the temperature response. From the tropics to the midlatitudes, changes in phase and amplitude are smaller and less spatially uniform than near the poles but are still prevalent in the models. These regions experience a small phase delay but an amplitude increase of the surface temperature cycle, a combination that is inconsistent with changes to the effective heat capacity of the system. The authors propose that changes in this region are controlled by changes in surface heat fluxes.
On the Generalized Eigenvalue Problem for the Rossby Wave Vertical Velocity in the Presence of Mean Flow and Topography
Authors: Tailleux Rémi 
Published: April 2012

Abstract
In a series of papers, Killworth and Blundell have proposed to study the effects of a background mean flow and topography on Rossby wave propagation by means of a generalized eigenvalue problem formulated in terms of the vertical velocity, obtained from a linearization of the primitive equations of motion. However, it has been known for a number of years that this eigenvalue problem contains an error, which Killworth was prevented from correcting himself by his unfortunate passing and whose correction is therefore taken up in this note. Here, the author shows in the context of quasigeostrophic (QG) theory that the error can ultimately be traced to the fact that the eigenvalue problem for the vertical velocity is fundamentally a nonlinear one (the eigenvalue appears both in the numerator and denominator), unlike that for the pressure. The reason that this nonlinear term is lacking in the Killworth and Blundell theory comes from neglecting the depth dependence of a depth-dependent term. This nonlinear term is shown on idealized examples to alter significantly the Rossby wave dispersion relation in the high-wavenumber regime but is otherwise irrelevant in the long-wave limit, in which case the eigenvalue problems for the vertical velocity and pressure are both linear. In the general dispersive case, however, one should first solve the generalized eigenvalue problem for the pressure vertical structure and, if needed, diagnose the vertical velocity vertical structure from the latter.
The Pretornadic Phase of the Goshen County, Wyoming, Supercell of 5 June 2009 Intercepted by VORTEX2. Part I: Evolution of Kinematic and Surface Thermodynamic Fields
Authors: Markowski Paul , Richardson Yvette , Marquis James , Wurman Joshua , Kosiba Karen , Robinson Paul , Dowell David , Rasmussen Erik , Davies-Jones Robert 
Published: April 2012

Abstract
The authors analyze the pretornadic phase (2100–2148 UTC; tornadogenesis began at 2152 UTC) of the Goshen County, Wyoming, supercell of 5 June 2009 intercepted by the second Verification of the Origins of Rotation in Tornadoes Experiment (VORTEX2). The analysis relies on radar data from the Weather Surveillance Radar-1988 Doppler (WSR-88D) in Cheyenne, Wyoming (KCYS), and a pair of Doppler-on-Wheels (DOW) radars, mobile mesonet observations, and mobile sounding observations.
The storm resembles supercells that have been observed in the past. For example, it develops a couplet of counter-rotating vortices that straddle the hook echo within the rear-flank outflow and are joined by arching vortex lines, with the cyclonic vortex becoming increasingly dominant in the time leading up to tornadogenesis. The outflow in the hook echo region, where sampled, has relatively small virtual potential temperature θυ deficits during this stage of evolution. A few kilometers upstream (north) of the location of maximum vertical vorticity, θυ is no more than 3 K colder than the warmest θυ readings in the inflow of the storm. Forward trajectories originating in the outflow within and around the low-level mesocyclone rise rapidly, implying that the upward-directed perturbation pressure gradient force exceeds the negative buoyancy.
Low-level rotation intensifies in the 2142–2148 UTC period. The intensification is preceded by the formation of a descending reflectivity core (DRC), similar to others that have been documented in some supercells recently. The DRC is associated with a rapid increase in the vertical vorticity and circulation of the low-level mesocyclone.
Exploring Impacts of Rapid-Scan Radar Data on NWS Warning Decisions
Authors: Heinselman Pamela L. , LaDue Daphne S. , Lazrus Heather 
Published: April 2012

Abstract
Rapid-scan weather radars, such as the S-band phased array radar at the National Weather Radar Testbed in Norman, Oklahoma, improve precision in the depiction of severe storm processes. To explore potential impacts of such data on forecaster warning decision making, 12 National Weather Service forecasters participated in a preliminary study with two control conditions: 1) when radar scan time was similar to volume coverage pattern 12 (4.5 min) and 2) when radar scan time was faster (43 s). Under these control conditions, forecasters were paired and worked a tropical tornadic supercell case. Their decision processes were observed and audio was recorded, interactions with data displays were video recorded, and the products were archived. A debriefing was conducted with each of the six teams independently and jointly, to ascertain the forecaster decision-making process. Analysis of these data revealed that teams examining the same data sometimes came to different conclusions about whether and when to warn. Six factors contributing toward these differences were identified: 1) experience, 2) conceptual models, 3) confidence, 4) tolerance of possibly missing a tornado occurrence, 5) perceived threats, and 6) software issues. The three 43-s teams issued six warnings: three verified, two did not verify, and one event was missed. Warning lead times were the following: tornado, 18.6 and 11.5 min, and severe, 6 min. The three tornado warnings issued by the three 4.5-min teams verified, though warning lead times were shorter: 4.6 and 0 min (two teams). In this case, use of rapid-scan data showed the potential to extend warning lead time and improve forecasters’ confidence, compared to standard operations.
Nicotine Replacement Therapy in the Intensive Care Unit
Authors: Wilby Kyle J. , Harder Curtis K. 
Published: April 2012

Objective: The objective of this review was to systematically review and evaluate available literature describing the effect of nicotine replacement therapy (NRT) on mortality and other outcomes in nicotine-dependent critically ill patients admitted to the intensive care unit (ICU). Data Sources: A systematic search of the following databases was performed: MEDLINE (1948-August 2011), EMBASE (1980-August 2011), Cochrane Database of Systematic Reviews, International Pharmaceutical Abstracts (1970-August 2011), Google, and Google Scholar. Study Selection: Studies that reported outcomes associated with any form of NRT in any intensive care setting were included. Studies were included regardless of design or number of participants reported. Studies published in languages other than English were excluded. Data Extraction: Data from each study were extracted using a standardized data extraction tool. Information included the study design, number of patients, classification of ICU, baseline characteristics, outcomes assessed, and overall results. Data Synthesis: Our search identified 8 studies, of which 7 met the inclusion criteria. These 7 studies were qualitatively reviewed and critically appraised for methodological quality, robustness of results, and internal and external validity. The results of similar studies and populations were compared in order to draw conclusions pertaining to specific intensive care settings. Conclusions: We conclude that NRT should not be routinely prescribed to patients admitted to intensive care settings. With only equivocal evidence of efficacy and signals suggesting increased toxicity, we believe that its use should be limited to selected patients where the potential benefit clearly outweighs the risk. There is a need for adequately powered randomized controlled trials to confirm the benefits and risks of NRT in the ICU overall but also in its unique subpopulations.
No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis
Authors: Amato MP , Saia V , Hakiki B , Giannini M , Pastò L , Zecchino S , Lori S , Portaccio E , Marinoni M 
Published: April 2012

Objective: Chronic cerebrospinal venous insufficiency (CCSVI) was hypothesized to play a causative role in multiple sclerosis (MS). The assessment of pediatric-onset MS (POMS) may provide a unique window of opportunity to study hypothesized risk factors in close temporal association with the onset of the disease. Methods: Internal jugular veins, vertebral veins and intracranial veins were evaluated with extracranial and intracranial ultrasound in 15 POMS and 16 healthy controls. Assessor’s blinding was maintained during the study. We considered subjects positive to CCSVI when at least two criteria were fulfilled. Results: CCSVI frequency was comparable between POMS and controls ( p > 0.05). Clinical features were not significantly different between CCSVI-positive and CCSVI-negative patients. Conclusions: Our findings add to previous data pointing against a causative role of CCSVI in MS.
The use of comorbidities among adults experiencing care transitions: a systematic review and evolutionary analysis of empirical literature
Authors: Buck Harleah G , Meghani Salimah , Bettger Janet Prvu , Byun Eeeseung , Fachko Michael J , O’Connor Melissa , Tocchi Christine , Naylor Mary 
Published: April 2012

Objective: To systematically review how comorbidities are employed in the empirical literature for adults coping with multiple chronic conditions during common episodes of acute illness that resulted in transition across health care setting. Methods: Evolutionary concept analysis inductively identifies current consensus regarding the usage of a concept and results in exploring attributes and clarification of the concept. Sixty studies from 1965 to 2009 identified from MEDLINE, CINAHL, PsychINFO, and ISI Web of Science databases were analysed. Results: Comorbidities were used heterogeneously among reviewed studies with most controlling for their presence ( n=33) and lacking robust measurement ( n=37). The designation of index or principal condition was equally heterogeneous with approximately half ( n=26) representing the main disease or diagnosis of interest to the researcher. In this study comorbidities were associated with personal, disease or system level antecedents and consequences. A conceptual framework is proposed. Discussion: The impact of comorbidities on the care and outcomes of adults coping with multiple chronic conditions is limited by heterogeneous and ambiguous usage. While analytic techniques have become more sophisticated, continued lack of meaningful conceptualization and instrument use has limited maturation of this important concept for research, practice and policy purposes.
Route duration improvement in wireless sensor and actuator networks based on mobility parameters and flooding control
Authors: Reina Daniel G , Toral Sergio L , Johnson Princy , Barrero Federico J 
Published: April 2012

Abstract
Mobility of nodes is one of the main causes of broken links in wireless networks. Although several theoretical models for links and routes selection have been proposed in the literature, so far little effort has been made to apply them to the existing routing protocols. In this article, a decision tree has been incorporated in a reactive routing protocol in order to select the most long-lived routes. The decision tree is based on nodes' mobility parameters typically considered by the theoretical models, such as distance between nodes, relative speed, and nodes' directions. The flooding techniques used within the routing protocols for the routing discovery procedures cause a massive usage of control packets which in turn has negative impact on the performance of the networks. So, an improved flooding control is presented in this article that enhances the performance of the proposed route selection based on a decision tree, in turn reducing overheads and the power consumption caused by the control packets. These two proposed approaches have been implemented over a widely used reactive routing protocol such as Ad Hoc On-Demand Distance Vector (AODV) to obtain performance results using Network Simulator 2 simulation tool. The performances of the proposed approaches have been compared with that of the AODV implementation in terms of general performance and path duration. The simulation results show that the proposed route selection significantly improves the results of AODV.
Docosahexaenoic acid ameliorates palmitate-induced lipid accumulation and inflammation through repressing NLRC4 inflammasome activation in HepG2 cells
Authors: Luo Xiaoqin , Yang Yan , Shen Tianran , Tang Xilan , Xiao Yunjun , Zou Tangbin , Xia Min , Ling Wenhua 
Published: April 2012

Abstract

Background
N-3 polyunsaturated fatty acids, such as docosahexaenoic acid (DHA; 22:6n-3), has clinical significance in the prevention and reversal of nonalcoholic steatohepatitis (NASH). However, the precious mechanism underlying remains unclear. The inflammasome, a multiprotein complex formed by NOD-like receptor (NLR) family members, has been recently shown to be activated in NASH and promote the cleavage of the pro-inflammatory cytokines to their maturation forms.

Methods
HepG2 cells were exposed to different dose of PA for 24 h with or without the preincubation of 50 μM DHA for another 24 h and then lipid deposition was assessed with Oil red O staining and intracellular triglyceride (TG) determination. Secretory levels of inflammatory cytokines and Caspase-1 activity were determined by ELISA assays. Gene expression and protein levels were determined by quantitative RCR and western blotting, respectively.

Results
Palmitate (PA) dose-dependently increased lipid accumulation, TG content and induced the secretion of interleukin-1β (IL-1β), IL-18, TNF-α and MCP-1 from HepG2 cells. Preincubation with DHA significantly alleviated PA-induced lipid accumulation and inflammatory agents. DHA was also found to attenuate PA-induced NOD-like receptor protein 4 (NLRC4) mRNA expression. Furthermore, PA induced caspase-1 activation in a dose-dependent manner, resulting in exacerbating of procaspase-1 and pro-IL-1β processing. Knockdown of NLRC4 partially abrogated PA-induced caspase-1 activation and IL-1β maturation and completely abolished these events in the presence of DHA.

Conclusions
Our findings indicate DHA attenuates PA-induced lipid accumulation and inflammation through suppressing NLRC4 inflammasome activation, caspase-1 activation and IL-1β cleavage.
Quantitative comparison of immunohistochemical staining measured by digital image analysis versus pathologist visual scoring
Authors: Rizzardi Anthony E , Johnson Arthur T , Vogel Rachel Isaksson , Pambuccian Stefan E , Henriksen Jonathan , Skubitz Amy PN , Metzger Gregory J , Schmechel Stephen C 
Published: April 2012

Abstract

Abstract
Immunohistochemical (IHC) assays performed on formalin-fixed paraffin-embedded (FFPE) tissue sections traditionally have been semi-quantified by pathologist visual scoring of staining. IHC is useful for validating biomarkers discovered through genomics methods as large clinical repositories of FFPE specimens support the construction of tissue microarrays (TMAs) for high throughput studies. Due to the ubiquitous availability of IHC techniques in clinical laboratories, validated IHC biomarkers may be translated readily into clinical use. However, the method of pathologist semi-quantification is costly, inherently subjective, and produces ordinal rather than continuous variable data. Computer-aided analysis of digitized whole slide images may overcome these limitations. Using TMAs representing 215 ovarian serous carcinoma specimens stained for S100A1, we assessed the degree to which data obtained using computer-aided methods correlated with data obtained by pathologist visual scoring. To evaluate computer-aided image classification, IHC staining within pathologist annotated and software-classified areas of carcinoma were compared for each case. Two metrics for IHC staining were used: the percentage of carcinoma with S100A1 staining (%Pos), and the product of the staining intensity (optical density [OD] of staining) multiplied by the percentage of carcinoma with S100A1 staining (OD*%Pos). A comparison of the IHC staining data obtained from manual annotations and software-derived annotations showed strong agreement, indicating that software efficiently classifies carcinomatous areas within IHC slide images. Comparisons of IHC intensity data derived using pixel analysis software versus pathologist visual scoring demonstrated high Spearman correlations of 0.88 for %Pos (p < 0.0001) and 0.90 for OD*%Pos (p < 0.0001). This study demonstrated that computer-aided methods to classify image areas of interest (e.g., carcinomatous areas of tissue specimens) and quantify IHC staining intensity within those areas can produce highly similar data to visual evaluation by a pathologist.

Virtual slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1649068103671302
A rare case of malignant triton tumor in the cerebellopontine angle
Authors: Gong Li , Liu Xiao-Yan , Zhang Wen-Dong , Han Xiu-Juan , Yao Li , Zhu Shao-Jun , Lan Miao , Li Yan-Hong , Zhang Wei 
Published: April 2012

Abstract

Abstract
Malignant triton tumor (MTT) is defined as malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. Intracranial MTT is extremely rare, and only four cases have been reported in the literature. Here, we report a case of MTT occurring in the cerebellopontine angle, and describe its histopathological characteristics, immunohistochemical features, and prognosis.

Virtual slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1336227313684480
Expression features of SOX9 associate with tumor progression and poor prognosis of hepatocellular carcinoma
Authors: Guo Xiaodong , Xiong Lu , Sun Ting , Peng Ruiyun , Zou Lin , Zhu Haiyan , Zhang Jing , Li Hanwei , Zhao Jingmin 
Published: April 2012

Abstract

Background
SOX9 as a member of the SOX (SRY [sex determining region Y] box) gene superfamily has been previously demonstrated to be a proto-oncogene in a variety of malignancies. However, the clinical significance of SOX9 expression in hepatocellular carcinoma (HCC) remains unclear. The aim of this study was to investigate the expression of SOX9 in HCC and determine its correlation with tumor progression and prognosis.

Methods
One-hundred and thirty HCC patients who had undergone curative liver resection were selected and immunohistochemistry, Western blotting, and quantitative real time polymerase chain reaction (Q-PCR) were performed to analyze SOX9 expression in the respective tumors.

Results
Immunohistochemistry, Western blotting, and Q-PCR consistently confirmed SOX9 overexpression in HCC tissues compared with their adjacent nonneoplastic tissues (P ≪ 0.01). Additionally, immunostaining showed more SOX9 positive cells in the higher tumor stage (T3 ~ 4) and tumor grade (G3) than in the lower tumor stage (T1 ~ 2, P = 0.03) and tumor grade (G1 ~ 2, P = 0.01), respectively. Moreover, HCC patients with high SOX9 expression were significantly associated with lower 5-year overall survival (P ≪ 0.01) and lower 5-year disease-free survival (P ≪ 0.01), respectively. The Cox proportional hazards model further showed that SOX9 over-expression was an independent poor prognostic factor for both 5-year disease-free survival (hazards ratio [HR] = 2.621, 95% confidence interval[CI] = 1.548-5.829, P = 0.01) and 5-year overall survival (HR = 3.825, CI = 1.638-7.612, P = 0.003) in HCC.

Conclusion
Our data suggest for the first time that the overexpression of SOX9 protein in HCC tissues is of predictive value on tumor progression and poor prognosis.

Virtual slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9029740396926377.