bluuebunny/crossref_metadata_2025_split huggingface dataset:
PNEUMONIA E VENTILAÇÃO MECÂNICA NA COVID-19: REVISÃO
Authors: Ferreira Cereser Eduardo Ferreira Cereser , Ricardo Siufi Magalhães  , Cintia Maria Saia Cereda  
Published: February 2025

A pandemia de COVID-19 causou uma impactante transformação global. Diante desse cenário, diversos estudos foram conduzidos para compreender a biologia do vírus, sintomas, prevenção e tratamento da doença. Em casos graves, a ventilação mecânica é crucial para a sobrevivência, mas paradoxalmente, pode aumentar o risco de pneumonia associada à ventilação mecânica (PAV). Visa avaliar a ocorrência de PAV em pacientes contaminados com o SARS-CoV 2 através de uma revisão sistemática. As bases de dados SCIELO, PUBMED, UpToDate e ScienceDirect foram pesquisadas sistematicamente até início de 2023 para identificar artigos relevantes. A indagação central deste estudo foi direcionada à análise de trabalhos que abordam a PAV em pacientes com COVID-19, incluindo a identificação dos principais agentes causadores. Através das buscas foram recuperadas 44 publicações e, após aplicação dos critérios de seleção, e exclusão de estudos de artigo de revisão, 23 estudos foram incluídos. Em metanálise realizada foi possível verificar que as bactérias mais prevalentes nos quadros de PAV foram: P. Aeruginosa (23,83%±0,12), Klebisiella sp. (21,78%±0,10) e S. Aureus (22,03%±0,11) e fungos foram: Aspergillus fumigatus (10,60%±0,07) e Candida spp. (24%±0,19). Com base em nossa revisão sistemática da literatura, há evidências de que os principais patógenos causadores da PAV em tempos de COVID 19 são oportunistas, os quais aproveitam-se das alterações celulares induzidas pela infecção por SARS-CoV-2 e da fragilidade imunológica para adquirirem patogenicidade. É válido ponderar também que a ventilação mecânica pode possibilitar a migração de microrganismos da microbiota das vias respiratórias superiores para as vias inferiores, sítios anômalos, desencadeando pneumonia.
Do children and adolescents with excess body weight and dyslipidemia consume enough vegetables and fruits before participating in the nutritional intervention program?
Authors: Bondyra-Wiśniewska Beata , Harton Anna 
Published: February 2025

BackgroundThe recommended intake of vegetables and fruits is an important element of dietotherapy in the treatment of excess body weight and dyslipidemia in children and adolescents.ObjectiveAssessment of vegetables and fruits consumption by children and adolescents with excess body weight and diagnosed dyslipidemia before participating in the nutritional intervention program.Material and MethodsThe study included 64 children and adolescents (44 boys and 20 girls) aged 8-16 with overweight or obesity and dyslipidemia. These were patients of the Children’s Memorial Health Institute in Warsaw referred by a pediatrician to participate in the nutritional intervention program. Vegetables and fruits consumption was estimated based on a 3-day current food record and the validated Food Frequency Questionnaire (FFQ-6).ResultsThe average consumption of total vegetables and fruits was 593±311 g, including 286±163 g of vegetables and 306±199 g of fruits (no differences in the groups with overweight and obesity, p>0.05). Compared to participants with overweight, patients with obesity consumed more vegetables per 1000 kcal of diet (p=0.034). In total, 41% of children and adolescents had a greater share of vegetables than fruits in meeting the recommendations (no differences between groups of participants with overweight or obesity, p>0.05). About half of the participants ate vegetables and fruits less than once a day. Raw vegetables and fruits were chosen more often than processed ones or juices.ConclusionsOnly 16% of children and adolescents with excess body weight and dyslipidemia before participating in the nutritional intervention program did not consume the recommended amounts of vegetables and fruits set at a minimum of 400 g. In nutritional education, special attention should be paid to promoting the consumption of several portions of vegetables and fruits every day, as well as their appropriate proportions.
Menaikkan performa dribbling sepakbola di usia muda melalui video tutorial
Authors: Pratama Vicky Yusid , Fajaruddin Syarief 
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan video tutorial teknik dasar dribbling sepakbola guna meningkatkan kecepatan dribbling pada usia 12-15 tahun di SSB Bintang Fajar. Metode penelitian menggunakan model prosedural "ADDIE" dengan langkah-langkah Analisis, Desain, Pengembangan Produk, Implementasi, dan Evaluasi. Instrumen yang digunakan meliputi angket, dokumentasi rancangan produk, dan pre-test & post-test untuk menilai peningkatan kecepatan dribbling. Teknik analisis data yang digunakan mencakup analisis kualitatif dan kuantitatif berupa persentase. Pengembangan teknik dribbling sepakbola ini melibatkan evaluasi dari para ahli sepakbola, permain sepakbola, dan ahli media. Hasil dari penelitian ini adalah video tutorial teknik dasar dribbling sepakbola yang disesuaikan dengan kebutuhan usia dan kondisi pandemi saat ini. Diharapkan pengembangan ini dapat memberikan kontribusi positif dalam meningkatkan keterampilan dribbling pada pemain usia muda.Â Improving youth soccer dribbling performance through video tutorialsÂ Abstract: This study aims to develop a video tutorial on basic soccer dribbling techniques to increase dribbling speed at the age of 12-15 years at SSB Bintang Fajar. The research method uses the "ADDIE" procedural model with the steps of Analysis, Design, Product Development, Implementation, and Evaluation. The instruments used include questionnaires, product design documentation, and pre-test & post-test to assess the increase in dribbling speed. The data analysis technique used includes qualitative and quantitative analysis in the form of percentages. The development of this soccer dribbling technique involves evaluation from soccer experts, soccer players, and media experts. The result of this research is a video tutorial on basic soccer dribbling techniques tailored to the needs of age and current pandemic conditions. It is hoped that this development can make a positive contribution in improving dribbling skills in young players.
Aktivitas fisik untuk meningkatkan keterampilan bermain sepak bola
Authors: Atiq Ahmad , Purwanto Didi , Ali Muhammad , Candra Gustian, Erik , Hidayatululloh Septianggi Afrizal , Rafli Rafli , Anggini Selvi Bella , Riski Riski , Jumantara Warapada Annisa , Nanda Fitri Agung 
Published: February 2025

Kegiatan aktivitas fisik bukan hanya sebagai media untuk meningkatkan dan memelihara derajat kesehatan manusia, banyak manfaat lain salah satunya adalah optimalnya peran dari kognitif dampak dari distribusi oksigen yang cukup ke otak manusia. Physical activity (PA) dapat mengembalikan setidaknya beberapa efek yang tidak diinginkan akibat gaya hidup sedentary secara nyata kalo di kaitkan dengan para pemain sepak bola yang terjadi sekarang dapat menunda penuaan otak, namun yang paling penting adalah PA dapat meningkatkan proses kognitif dan daya ingat, antidepresan bahkan menginduksi perasaan bahagia Secara fisiologis aktivitas fisik yang baik dapat membantu manusia untuk mengoptimalkan fungsi-fungsi otak. Aktivitas fisik yang menarik dapat menjadi salah satu cara yang menjanjikan untuk meningkatkan fungsi kognitif seseorang karena beberapa bukti menunjukkan bahwa aktivitas fisik memiliki dampak positif untuk performa akademik Namun, Tujuan penelitian ini adalah untuk mengidentifikasi jenis aktivitas fisik yang dilakukan peserta didik kemudian menganalisis jenis aktivitas fisik yang relevan guna mendukung keterampilan bermain sepak bola. Penelitian ini menggunankan Metode penelitian yang di gunakan dengan pendekatan diskriftif kuantitatif Classroom Action Research (CAR) adalah cara menentukan bagaimana cara melakukanya pengambilan data yang di mulai dariÂ siklus. I maupun II kegiatan penelitian, cara memperoleh data ini dikenal sebagai metode pengumpulan data, Analisis dataÂ Dengan Penelitian Tindakan Kelas Khususnya mahasiswa angkatan 2023 Yang Berjumlah 45 di dapatkan sebagai berikutÂ Siklus 1 Lulus 25 mahasiswa Dengan Persentasi 55 % Dan yang belum lulus berjumlah 20 peserta didik dengan persentasi 45 % Di Lanjutkan Siklus II Dengan Perbaikan Perencanaan Dan Pelaksaan yang lebih baik denga tingkat Akurat Dan Tepat Sasaran Mengunakan keterampilan dimana seluruh atlet mendalamÂ Baru Bisa Di Katakan Lulus 45 Peserta Didik Dengan Persentasi 100 %.
Hubungan antara konsentrasi dan kepercayaan diri dengan kemampuan tendangan penalti pada futsal
Authors: Sinangling Rival , Ariestika Elsa , Fahmi Fadlilah , Richard Victorian Ahmad 
Published: February 2025

Konsentrasi dan kepercayaan diri merupakan aspek yang berpengaruh pada performa atlet dalam pertandingan futsal, terlebih pada keadaan krusial seperti tendangan penalti. Penelitian ini bertujuan untuk mengetahui korelasi antara konsentrasi dan kepercayaan diri terhadap kemampuan tendangan penalti futsal. Metode yang digunakan yaitu desain penelitian korelasional dengan deskriptif kuantitatif. Pengambilan sampel menggunakan teknik purposive sampling dan didapatkan sebanyak 30 siswa laki-laki kelas 7 dan kelas 8 yang masih aktif mengikuti ekstrakurikuler futsal di MA Al-Islah Cikeusal. Instrumen konsentrasi menggunakan Grid Concentration Test, kepercayaan diri menggunakan kuesioner skala Likert, dan tendangan penalti menggunakan Tes Tendangan Penalti. Teknik analisis data terdiri dari uji prasyarat dan uji hipotesis menggunakan uji regresi linear berganda. Hasil penelitian menunjukan bahwa (1) ada korelasi antara konsentrasi terhadap kemampuan tendangan penalti futsal, (2) ada korelasi antara kepercayaan diri terhadap kemampuan tendangan penalti futsal, dan (3) ada korelasi antara konsentrasi dan kepercayaan diri secara simultan terhadap kemampuan tendangan penalti futsal. Penelitian ini menunjukkan bahwa konsentrasi dan kepercayaan diri berperan penting dalam keadaan krusial pertandingan futsal seperti tendangan penalti. The association between concentration and self-confidence with penalty kick ability in futsal Abstract: Concentration and self-confidence affect athletes' performance in futsal matches, especially in crucial circumstances such as penalty kicks. This study aimed to determine the correlation between concentration and self-confidence in futsal penalty-kicking abilities. The study employed a correlational research design with a descriptive quantitative approach. A purposive sampling technique was used to select a sample of up to 30 male students in 7th and 8th grade who were actively participating in extracurricular futsal at MA Al-Islah Cikeusal. Concentration scores were obtained using the Grid Concentration Test, a Likert scale questionnaire for self-confidence, and a Penalty Kick Test for penalty kick score. The data analysis technique consists of prerequisite tests and hypothesis testing using multiple linear regression tests. The results showed that (1) there is a correlation between concentration on futsal penalty kicking ability, (2) there is a correlation between self-confidence on futsal penalty kicking ability, and (3) there is a correlation between concentration and self-confidence simultaneously on futsal penalty kicking ability. This research indicated that concentration and self-confidence are important in crucial circumstances of futsal matches, such as penalty kicks.
Metabolomics study of osteopetrosis caused by CLCN7 mutation reveals novel pathway and potential biomarkers
Authors: Chen Xi , Wang Ziyuan , Fu Wenzhen , Wei Zhe , Gu Jiemei , Wang Chun , Zhang Zhenlin , Yu Xiangtian , Hu Weiwei 
Published: February 2025

ObjectiveCLCN7 mutation caused abnormal osteoclasts, resulting in osteopetrosis. Depending on the type of mutation, CLCN7 mutations can lead to severe or relatively benign forms of osteopetrosis. However, the serum metabolic alterations in osteopetrosis caused by CLCN7 mutation are still unknown. We aimed to investigate the differences in the metabolome of osteopetrosis patients caused by CLCN7 mutation versus healthy controls (HC), uncovering potential subtype diagnosis biomarkers.Methods19 osteopetrosis patients caused by CLCN7 mutation and 19 HC were recruited for liquid chromatography–tandem mass spectrometry analysis. The screened pathway was validated in the myeloid cell specific Clcn7G763R mutant mouse model by quantitative real-time PCR analysis.ResultsThree metabolic pathways were significantly enriched, including glycerophospholipid metabolism (P=0.036948), arachidonic acid metabolism (P=0.0058585) and linoleic acid metabolism (P=0.032035). Ten differential expressed metabolites were located in these three pathways and classified ability with areas under the curve over 0.7 in receiver operating characteristic analysis, suggesting a certain accuracy for being the potential biological markers. Especially, we found that the proteins in glycerophospholipid metabolism were predicted to interact with ClC-7 and further verified that the expression of coding genes were significantly up-regulated in myeloid cell specific Clcn7G763R mutant mouse.ConclusionThis study provides data on serum metabolomics in osteopetrosis caused by CLCN7 mutation and provides new potential metabolic markers and pathways for diagnosis and pathogenesis of osteopetrosis.
T1-relaxation times along the corticospinal tract as a diagnostic marker in patients with amyotrophic lateral sclerosis
Authors: Dierksen Fiona , Geibel Johanna S. , Albrecht Janika , Hofer Sabine , Dechent Peter , Hesse Amelie C. , Frahm Jens , Bähr Mathias , Koch Jan C. , Liman Jan , Maier Ilko L. 
Published: February 2025

Background and purposeIn the differential diagnostic workup of amyotrophic lateral sclerosis (ALS), magnetic resonance imaging (MRI) is primarily used to rule out significant differential diagnoses. So far, whole-brain T1-mapping has not been assessed as a diagnostic tool in this patient population.MethodsWe investigated the diagnostic potential of a novel T1-mapping method based on real-time MRI with 0.5 mm in-plane resolution and 4s acquisition time per slice. The study included patients aged 18 to 90 years who met the revised El Escorial criteria for at least possible ALS. T1-relaxation times were measured along the corticospinal tract in predefined regions of interest.ResultsTwenty-nine ALS-patients and 43 control group patients (CG) were included in the study. Median ALS Functional Rating Scale revised (ALSFRS-R) was 37 (IQR, 35–44) points and the mean duration from symptom onset to MRI was 21 ± 17 (SD) months. ALS patients showed significantly higher T1-relaxation times in all ROIs compared to CG with mean differences in the hand knob of 50 ms (p &lt; 0.001), corona radiata 24 ms (p = 0.034), internal capsule 27 ms (p = 0.002) and midbrain peduncles 48 ms (p &lt; 0.001). There was a consistent negative correlation between the ALSFRS-R and T1-relaxation times in all ROIs.ConclusionsT1-relaxation times along the corticospinal tract are significantly elevated in ALS patients compared to CG and associated with lower ALSFRS-R. These results imply the analysis of T1-relaxation times as a promising diagnostic tool that can distinguish ALS patients from the control group. Ongoing longitudinal studies may provide deeper insights into disease progression and the effects of therapeutic interventions.
Changes in the Expression Profile of Growth-Associated Protein 43 in Degenerative Lumbosacral Stenosis
Authors: Sobański Dawid , Sobańska Małgorzata , Staszkiewicz Rafał , Strojny Damian , Grabarek Beniamin Oskar 
Published: February 2025

Background: Degenerative spinal stenosis is a common condition associated with structural degeneration and pain, yet its molecular underpinnings remain incompletely understood. Growth-associated protein 43 (GAP-43), a key player in neuronal plasticity and regeneration, may serve as a biomarker for disease progression and pain severity. This study investigates the expression of GAP-43 at the mRNA and protein levels in the ligamentum flavum of affected patients. Methods: Samples were collected from 96 patients with degenerative spinal stenosis and 85 controls. GAP-43 mRNA expression was analyzed using reverse transcription–quantitative polymerase chain reaction (RT-qPCR), while protein levels were quantified via enzyme-linked immunosorbent assay (ELISA) and Western blot. Pain severity was assessed using the visual analog scale (VAS), and associations with lifestyle factors were analyzed. Results: GAP-43 mRNA expression was significantly downregulated in the study group compared to the controls (fold change = 0.58 ± 0.12, p < 0.05), with an inverse correlation to VAS pain severity (fold change = 0.76 at VAS 4 vs. 0.36 at VAS 10). Conversely, GAP-43 protein levels were markedly elevated in the study group (5.57 ± 0.21 ng/mL) when compared to controls (0.54 ± 0.87 ng/mL, p < 0.0001). Protein levels were also correlated with lifestyle factors, including smoking and alcohol consumption (p < 0.05). Conclusions: GAP-43 shows potential as a biomarker for pain severity and disease progression in degenerative spinal stenosis, in a manner influenced by lifestyle factors. Further research is needed to explore its diagnostic and therapeutic applications.
Коагуляционная очистка природных вод солями окисного железа
Authors: Гандурина Л.В. , Кравченко Д.С. 
Published: February 2025

Рассмотрена эффективность применения хлорида и сульфата окисного железа для коагуляционной очистки природных и модельных вод в зависимости от мутности, цветности, щелочности исходной воды и продолжительности хлопьеобразования. Показано, что для очистки мутных вод дозы коагулянтов по иону железа не зависят от вида коагулянта и увеличиваются с ростом мутности очищаемой воды. Найдена степенная зависимость дозы хлорида железа от мутности исходной воды. Для снижения мутности и цветности самым эффективным коагулянтом, одновременно обеспечивающим нормативное содержание ионов железа в очищенной воде, является хлорид железа. Более высокая эффективность хлорида железа по сравнению с сульфатом окисного железа определяется наличием в растворах хлорида железа полиоксихлоридных комплексов. Установлено, что основной вклад в снижение мутности воды, коагулированной солями окисного железа, вносит щелочность, определяющая скорость и количество образующихся нерастворимых продуктов гидролиза солей окисного железа. На примере коагуляционной очистки цветных вод разных водоисточников с применением солей окисного железа показано, что с увеличением цветности и щелочности исходной воды не наблюдается четкой корреляционной зависимости дозы и эффективности очистки от этих параметров.
The efficiency of using ferric chloride and ferric sulphate for coagulation purification of natural and model water depending on the turbidity, color, alkalinity of the source water and flocculation duration is considered. It is shown that for the purification of turbid water, the doses of coagulants related to the iron ion do not depend on the type of coagulant and increase with rise of the turbidity of the purified water. Power dependence of the dose of ferric chloride on the turbidity of the source water was determined. Ferric chloride is the most effective coagulant for reducing turbidity and color, simultaneously providing for the standard concentration of iron ions in purified water. The higher efficiency of ferric chloride compared to ferric sulphate is determined by the presence of polyoxychloride complexes in ferric chloride solutions. It has been established that the main contribution to the reduction of turbidity of water coagulated with iron oxide salts is made by alkalinity that determines the rate and amount of insoluble products of hydrolysis of iron oxide salts. Using the example of coagulation purification of colored waters from different water sources using iron oxide salts, it has been shown that with an increase in color and alkalinity of the source water, no clear correlation dependence of the dose and purification efficiency on these parameters is observed.
PERBANDINGAN TINGKAT KECEMASAN SEBELUM DAN SETELAH INTERVENSI EFFLURAGE MASSAGE DAN SUPPORT SYSTEM SUAMI SAAT KEHAMILAN TRIMESTER III SAMPAI SETELAH PROSES INTRANATAL PADA IBU PRIMIGRAVIDA DI KLINIK BIDAN MUTIARA PURWAKARTA
Authors: Anggi Geuis , Ati Nung 
Published: February 2025

Kecemasan merupakan masalah psikologi yang sering dan banyak dialami oleh ibu hamil terutama primigravida trimester III sebetulnya kecemasan ini bersifat fisiologis namun jika tidak teratasi dapat berdampak buruk baik pada kesehatan ibu maupun janin, oleh karena itu perlu ada intervensi yang dapat mencegah serta mengatasi kecemasan. Intervensi yang dapat digunakan untuk mencegah dan mengatasi kecemasan adalah intervensi farmakologi dan non farmakologi. Intervensi non farmakologi yang sering digunakan adalah pijat, latihan nafas, aromaterapi, kompres hangat, terapi musik dan dukungan suami. Teknik non farmakologi yang dipilih dalam penelitian ini adalah pijat dan dukungan suami. intervensi ini dipilih karena menurut penelitian sebelumnya sangat efektif, mudah, murah, tidak memerlukan sertifikasi khusus dan masuk ke dalam program pemerintah “asuhan sayang ibu”. Tujuan penelitian untuk mengetahui perbandingan tingkat kecemasan sebelum dan setelah intervensi. Metode penelitian yang di gunakan Pre-Experimental dengan one group pretest and posttest design. Subjek penelitian adalah ibu hamil trimester III. Subjek intervensi adalah seluruh subjek penelitian dan suami. Teknik pengambilan sampel dengan consecutive sampling. Jumlah sampel 25 (n=25). Pengambilan data dilakukan April sampai September 2025. Pengukuran kecemasan dengan menggunakan kuisioner PASS (Perinatal Anxiety Screnning Scale). Hasil uji validitas p<0,05 dan reliabilitas 0,06. Analisa data, menggunakan Wilcoxon. Hasil Penelitian menunjukkan tingkat kecemasan sebelum intervensi, mengalami kecemasan berat sebanyak 20 orang (80%) dengan skor nilai 28-41 sedangkan setelah dilakukan intervensi mengalami kecemasan ringan sebanyak 21 orang (84%) dengan skor 14-20, menunjukan adanya penurunan skor kecemasan sebesar 10,2 (95% IK 8–12). Terdapat perbedaan signifikan rerata tingkat kecemasan sebelum dan setelah intervensi dengan nilai p value 0,001.
O pensamento algébrico no documento curricular de Roraima nos anos iniciais do Ensino Fundamental
Authors: Alencar Edvonete Souza de 
Published: February 2025

O presente artigo tem como objetivo identificar como o pensamento algébrico tem sido abordado no documento curricular do estado de Roraima nos anos iniciais do Ensino Fundamental. Essa investigação faz parte de uma pesquisa maior que contempla analisar como o pensamento algébrico tem sido apresentado nos documentos curriculares dos diferentes estados brasileiros. Para o seu desenvolvimento realizamos uma análise documental do documento que rege a educação estadual de Roraima. A seleção por esse estado se deu por este estar no norte do país, em uma região extrema e afastada dos grandes centros. Salientamos ainda que o fato desse estar em região fronteiriça e ter nos últimos anos recebidos um considerável número de refugiados, nos instigou a realização dessa investigação. Como resultados nas análises identificamos que o eixo segue as diretrizes da Base Nacional Comum Curricular e nota-se poucas adaptações e sugestões para a flexibilidade regional.