bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship of peripheral blood lncRNA-PVT1 and miR-146a levels with Th17/Treg cytokines in patients with Hashimoto’s thyroiditis and their clinical significance
Authors: Li Yi-nan , Shen Jingxue , Feng Yinglan , Zhang Yingyan , Wang Yusi , Ren Xinyu 
Published: May 2024

Hashimoto’s thyroiditis (HT) is a prevalent autoimmune disease. We investigated the relationship of peripheral blood long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) and microRNA (miR)-146a levels with Th17/Treg-related cytokines in HT patients and their clinical significance. Correlations of PVT1 and miR-146a with Th17/Treg-related cytokines were analyzed, and its clinical value in diagnosing HT was assessed. Results showed reduced lncRNA-PVT1 and interleukin (IL)-10 levels and increased miR-146a and IL-17 levels in HT patients. lncRNA-PVT1 negatively interrelated with miR-146a, IL-17, IL-23 and IL-6, and positively interrelated with IL-10; miR-146a positively correlated with IL-17, IL-23 and IL-6, but negatively correlated with IL-10 in HT patients. The area under the curve (AUC) of lncRNA-PVT1 and miR-146a levels for diagnosing HT were 0.822 and 0.844, respectively (sensitivity 88.73% and 86.62%, specificity 67.02% and 69.15%, cut-off values 0.76 and 2.73), with their combined detections yielding a higher AUC. Patients with poorly expressed lncRNA-PVT1 and highly expressed miR-146a had elevated HT incidence. lncRNA-PVT1 and miR-146a levels were also found to be an independent influencing factor for HT occurrence. Our findings suggest that HT patients have low peripheral blood lncRNA-PVT1 expression and high miR-146a expression. lncRNA-PVT1 and miR-146a level changes were correlated with Th17/Treg cytokine imbalance and could be a potential diagnostic tool and independent influencing factor for HT.
Inclusive Local Irregularity Vertex Coloring In Grid Graph Family
Authors: Kristiana Arika Indah , Agatha Alvian Bagus , Hussen Saddam , Prihandini Rafiantika Megahnia , Kurniati Dian , Alfarisi Ridho 
Published: May 2024

Let is a simple graph and connected where is vertex set and is edge set. A maping as vertex k- labeling and function : is inclusive local irregularity vertex coloring, with . The minimum number of colors produced from inclusive local irregularity vertex coloring of graph is called inclusive chromatic number local irregularity, denoted by . On this paper, we learn about the inclusive local irregularity vertex coloring and determine the chromatic number on grid graph family.
The Reflexive H-Strength on Some Graphs
Authors: Sullystiawati Lusia Herni , Marsidi Marsidi , Putra Eric Dwi , Agustin Ika Hesti 
Published: May 2024

Let G be a connected, simple, and undirected graph with a vertex set V(G) and an edge set E(G). The irregular reflexive -labeling is defined by the function and such that if and if , where max . The irregular reflexive labeling is called an -irregular reflexive -labeling of the graph if every two different sub graphs and isomorphic to it holds , where for the sub graph . The minimum for graph which has an -irregular reflexive -labelling is called the reflexive strength of the graph and denoted by . In this paper we determine the lower bound of the reflexive strength of some subgraphs, on , the sub graph on the sub graph on and the sub graph on .
Revolutionizing lathe efficiency by bridging theory-practice gaps
Authors: Budi Angga Bagus Styo , Mulyadi Mulyadi 
Published: May 2024

This study explores the development of a Ball Turning Attachment for lathes to enhance efficiency in manufacturing spherical workpieces. Utilizing materials such as ST 37 and ST 42, the research focuses on the machining processes of milling, drilling, and turning. Despite theoretical estimations suggesting a total work time of 8 minutes 23 seconds, actual implementation records a duration of 12 minutes 23 seconds, highlighting a significant knowledge gap. Experimental procedures conducted in lathe workshops reveal discrepancies between theoretical and actual work times, influenced by factors like feed depth and manual drilling processes. Findings underscore the importance of optimizing tool design and feed rates to improve machining efficiency, offering practical insights for enhancing lathe manufacturing processes and productivity.

Highlight:

Develop Ball Turning Attachment for lathe manufacturing efficiency.
Address discrepancies between theoretical and actual work times.
Extract practical insights for enhancing lathe manufacturing processes.

Keyword: Lathe manufacturing, Ball Turning Attachment, Machining efficiency, Tool optimization, Experimental procedures
Slowdown of typhoon translation speed and its links to the storm poleward migration
Authors: Feng Xiangbo 
Published: May 2024

Abstract

Detecting and interpreting long-term changes in typhoon translation speed in observations remains challenging, contrasting with the increased confidence in the poleward migration of typhoons. Here, I show a significant relationship between the basin-wide translation speed and the latitudinal position of typhoons in the western North Pacific over 1980–2023. There are two key findings. First, because typhoons move faster at higher latitudes, the significant poleward migration (80 km/decade) increases the yearly basin-wide translation speed by 5% over the period. This effect reduces the detectability of a slowing trend in typhoon translation speed. Second, the basin-wide translation speed solely contributed by regional translation speed has significantly slowed by 18%. The translation speed slowdown and the poleward migration are likely caused by the same climate drivers through the interconnected large-scale atmospheric circulation between the tropics and subtropics. My findings suggest exacerbated typhoon-related risk in the subtropical regions in a changing climate.
A Possible Method of Using Astronomical Observations to Probe Quantum Kinematic Properties of Gravity
Authors: Zhao Dongcheng 
Published: May 2024

Abstract

The Newtonian gravity considers gravity is a force that action at a distance, however, if gravity is quantized, then it should not be an instantaneous force, but propagates toward a direction at the speed of light by gravitational quanta. The quantum kinematic gravitational equation is a possible new way to describe gravity which established based on Newton’s gravitational equation and quantum theory. Here is a possible method of using quantum kinematic gravitational equation to describe the anomalous acceleration of 1I/2017 U1 'Oumuamua, the margin of error between the result calculated by the equation and the astronomical observation during Oct 19, 2017 - May 3, 2018 is approximately 8% − 10%. There should be an angle difference in the tangential direction of approximate 28 arcseconds between its trajectories calculated respectively by quantum kinematic gravitational equation and by the Newton’s gravitational equation, during Oumuamua's whole journey in the Solar system. The accumulation of extra velocity caused by quantum kinematic gravitational force may provide extra kinetic energy, which may be one of the reasons the Moon orbital expansion.
Beneficial redox activity of halide solid electrolytes empowering high-performance anodes in all-solid-state batteries
Authors: Wagemaker Marnix , Cheng Zhu , Zhao Wenxuan , Wang Qidi , Zhao Chenglong , Lavrinenko Anastasia K. , Vasileiadis Alexandros , Landgraf Victor , Bannenberg Lars , Ganapathy Swapna 
Published: May 2024

Abstract

All-solid-state batteries receive ample attention having the potential to outperform Li-ion batteries in safety characteristics and energy density. The latter holds true if they are compatible with next-generation high-capacity anodes. However, most highly ion-conductive solid electrolytes decompose at the low operating potentials of next-generation anodes, leading to irreversible lithium loss and increased cell resistances. Here we introduce the concept of the dynamic stability of solid electrolytes, and demonstrate how this phenomenon can be utilized to improve all-solid-state battery performance. Halide electrolytes such as Li3YCl3Br3 and Li2ZrCl6, considered unstable at low working potentials, are shown to exhibit a structurally reversible redox activity beyond their electrochemical stability windows. Low potentials result in reversible lithiation of these halide solid electrolytes, introducing three advantages to the benefit of all-solid-state battery performance. First, the dynamic stability window is wider than their electrochemical stability window, thereby increasing their compatibility with anodes. Second, the lithiation of these halides increases their ionic conductivity rather than compromising it. Finally, the solid electrolyte contributes to the reversible capacity of the all-solid-state battery. The benefit of this dynamic stability window is demonstrated through halide-based cost-effective red phosphorus anodes that fall within this window, resulting in high reversible capacities (2308 mAh g− 1), high rate capacity retention (1024 mAh g− 1 at 7.75 mA cm− 2) and an extended cycle life (61% retention after 1780 cycles). Furthermore, high areal capacity (7.65 mAh cm− 2) and stability (70% retention after 1000 cycles) are achieved for exclusive halide-based full cells with uncoated high-voltage cathodes in combination with red phosphorous anodes. The beneficial redox activity of halide electrolytes that is unveiled, opens up novel application scenarios and suggests new solid electrolyte and solid-state battery design principles to enhance performance.
Myeloid NCOA4 sequesters KEAP1 to reduce ferroptosis for protection against salmonellosis in mice.
Authors: Xue Xiang , Arcos Mariella , Liu Zhaoli , Villareal Luke , Velez Paloma Kai , Desai Sharina , Noureddine Achraf , Martin David , Brinker C , Zhang Donna 
Published: May 2024

Abstract

Salmonellosis is a severe infection caused by Salmonella enterica serovar Typhimurium, leading to significant global morbidity and mortality. Host nutrition immunity restricts extracellular bacterial replication by reducing iron availability through the induction of the antimicrobial hormone hepcidin. Hepcidin degrades the iron exporter ferroportin, limiting intestinal iron uptake and reducing iron transfer into the blood. Paradoxically, this defense mechanism increases iron storage in macrophages, fostering an environment conducive to intracellular pathogens like Salmonella to proliferate and disseminate. Mice lacking the iron storage protein ferritin heavy chain (FTH1) in myeloid cells exhibit worsened Salmonella infection. Nuclear receptor co-activator 4 (NCOA4) directs FTH1 autophagic degradation to release iron from storage during conditions of low iron. However, the role of myeloid NCOA4 in regulating salmonellosis and gut pathophysiology remains unclear. Here, we reveal that myeloid NCOA4 deficiency augments spleen iron levels and increases cellular iron accumulation, oxidative stress, and ferroptosis in bone marrow-derived macrophages (BMDM) cells. This deficiency also increases susceptibility to Salmonella-induced colitis in mice due to exacerbated oxidative stress and ferroptosis. Mechanistically, NCOA4 suppresses oxidative stress by directly binding to the E3 ubiquitin ligase Kelch-like ECH-associated protein 1 (KEAP1) and stabilizing the antioxidant transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2). Activation of NRF2 protects myeloid NCOA4 knockout mice from Salmonella-induced colitis. Antioxidants Tempol and curcumin offer protection against colitis in myeloid NCOA4-deficient mice. A low iron diet and ferroptosis inhibition also mitigate the heightened colitis in these mice. Overexpression of myeloid cell-specific NCOA4 confers protection against Salmonella-induced colitis via upregulating NRF2 signaling. Together, this study not only advances our understanding of myeloid iron metabolism but also paves the way for novel myeloid cell-targeted therapies to combat salmonellosis.
Designing Molecular RNA Switches with Restricted Boltzmann Machines
Authors: Cocco Simona , Díaz Jorge Fernández de Cossío , Hardouin Pierre , du Moutier Francois-Xavier Lyonnet , Gioacchino Andrea Di , Marchand Bertrand , Ponty Yann , Sargueil Bruno , Monasson Rémi 
Published: May 2024

Abstract

Riboswitches are structured allosteric RNA molecules that change conformation in response to a metabolite binding event, eventually triggering a regulatory response. Computational modelling of the structure of these molecules is complicated by a complex network of tertiary contacts, stabilized by the presence of their cognate metabolite. In this work, we focus on the aptamer domain of SAM-I riboswitches and show that Restricted Boltzmann machines (RBM), an unsupervised ma- chine learning architecture, can capture intricate sequence dependencies induced by secondary and tertiary structure, as well as a switching mechanism between open and closed conformations. The RBM model is then used for the design of artificial allosteric SAM-I aptamers. To experimentally validate the functionality of the designed sequences, we resort to chemical probing (SHAPE-MaP), and develop a tailored analysis pipeline adequate for high-throughput tests of diverse homologous sequences. We probed a total of 476 RBM designed sequences in two experiments, showing between 20% and 40% divergence from any natural sequence, obtaining ≈ 30% success rate of correctly structured aptamers that undergo a structural switch in response to SAM.
Speech Therapy for Poststroke Aphasia: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors: Yang Fu-An , Huang Chao-Chun , Lu Chao-Hsien , Wu Pei-Jyuan , Escorpizo Reuben , Chen Hung-Chou 
Published: May 2024

Abstract

Various speech therapies are available for treating poststroke aphasia; however, the effects of these strategies on poststroke aphasia have yet to be compared. We conducted a systematic review and network meta-analysis to investigate the effects of different speech therapies for patients with poststroke aphasia. We searched the PubMed, EMBASE, and Cochrane Library electronic databases from their inception to September 20, 2023. We included trials that (1) involved participants with poststroke aphasia; (2) adopted speech therapy as the intervention; (3) applied either no intervention or another speech therapy as the control treatment; (4) reported speech performance as outcomes. The network meta-analysis was performed using the online tool ShinyNMA (version 1.01). We examined 16 articles involving 775 patients. Our analyses revealed that constraint-induced aphasia therapy (CIAT) prompted significant improvements in speech and motor aphasia performance, whereas computerized speech and language therapy (CSLT) yielded significant improvements in motor aphasia performance. All significant results were also clinically meaningful. No significant inconsistencies were observed between the results of direct and indirect comparisons. Our results suggest CIAT should be the preferred protocol for improving speech performance in patients with poststroke aphasia, with CSLT being a favorable alternative in patients with motor aphasia.
Analysis of the Therapeutic Effectiveness of Segmental Lung Resection Versus Lobectomy in Patients with Isolated Lung Metastases from Colorectal Cancer
Authors: Que Chang-Hao , Jin Dacheng , Wang Qi , Ye ZhiBO , Wang YaPing , Li Chengfang , Lu Peiyuan , Gou yunjiu 
Published: May 2024

Abstract

In patients with solitary pulmonary metastasis from colorectal cancer, surgical resection is considered a standard treatment protocol and routinely performed in thoracic surgery. However, there is a paucity of studies that delve into the detailed discussion of the efficacy and safety of lobectomy and segmentectomy in the treatment of pulmonary metastatic cancer. Our study retrospectively analyzed the surgical outcomes of 62 patients from a single center and reported the findings. In comparison to the group undergoing lung segmental resection, the cohort receiving lobectomy exhibited significantly larger tumor diameters (P < 0.001), prolonged operative durations (P < 0.001), increased intraoperative bleeding (P = 0.002), augmented drainage volume on the first postoperative day (P < 0.001), greater total postoperative drainage (P < 0.001), and elevated operative costs (P < 0.001). Pulmonary segmentectomy offers superior advantages in terms of operative time, intraoperative blood loss, drainage volume on the first postoperative day, total postoperative drainage volume, and surgical costs.
Explainable Gradient Boosting for Corporate Crisis Forecasting in Italian Businesses
Authors: Riccio Donato , Maturo Fabrizio , Mazzitelli Andrea , Bifulco Giuseppe , Paolone Francesco 
Published: May 2024

Abstract

Scholars have taken a keen interest in predicting corporate crises in the past decades. However, most studies focused on classical parametric models that, by their nature, can consider few predictors and interactions and must respect numerous assumptions. Over the past few years, the economy has faced a severe structural crisis that has resulted in significantly lower income, cash, and capital levels than in the past. This crisis has led to insolvency and bankruptcy in many cases. Hence, there is a renewed interest in research for new models for forecasting business crises using novel advanced machine learning techniques. This study aims to develop a model that achieves state-of-the-art accuracy while being fully interpretable, overcoming the limitations of previous research. The model demonstrates excellent predictive performance on par with black-box approaches while maintaining complete transparency by leveraging Explainable Boosting Machines, an intrinsically interpretable tree-based ensemble method, and hyperparameter optimization. The approach automatically considers all possible interactions and uncovers relevant aspects not considered in past studies. This line of research provides compelling results that can bring new insights to the literature on corporate crisis prediction. The interpretable nature of the model is a key advancement, enabling practical application and a deeper understanding of the factors driving corporate financial distress.
Effects of different flocculants and environment on the flocculation effect of potato starch-processing wastewater
Authors: Suo Na , Li Xiaoqiang , Wu Jian 
Published: May 2024

ABSTRACT
Potato starch-processing wastewater belongs to high-concentration organic wastewater, as direct discharge is more polluting to the environment. Flocculation treatment, as the initial process of wastewater purification, can remove large debris in wastewater, reduce energy consumption for subsequent treatment and reduce production costs. In this study, the effects of traditional flocculants and biological flocculants on the treatment of potato starch-processing wastewater under different pH, dosage, stirring rate and settling time were studied. It was found that traditional flocculants and biological flocculants have their own advantages in the purification ability of organic matter, and the removal rates of suspended solids (SS) and total phosphorus (TP) of traditional flocculants are better than biological flocculants for sweet potato starch-processing wastewater, but the flocculation time and settling time are long. Biological flocculants are environmentally friendly, safe and non-polluting, and do not produce secondary pollution when the flocculation treatment of wastewater is conducive to the secondary reuse of wastewater and flocculation sediment resource treatment. According to the flocculation effect and cost, chitosan is the best flocculant for treating sweet potato starch-processing wastewater.
Human Umbilical Cord Mesenchymal Stem Cell-derived Exosomes Induce
Macrophage M2 Polarization by Antagonizing LPS-mediated Stimulation
of the NF-κB and STAT3 Pathways
Authors: Tian HengJin , Chen AMin , Gao PeiYao , Wang FeiFan , Zhao YanMing , Wang FengChao , Lian Chaoqun , Zhang Qiang 
Published: May 2024

Background::
Many studies have documented the protective effects of regulating
macrophage M1/M2 polarization in inflammatory diseases characterized by their imbalance
state. In pathological diseases associated with inflammation, mesenchymal stem cells (MSCs)
regulate macrophages, thereby having anti-inflammatory and tissue regenerative effects. Exosomes
have been suggested as an alternative mechanism that underlies the paracrine function of
MSCs. Thus, this study explored the anti-inflammatory impact of human umbilical cord MSCssecreted
exosomes (hucMSCs-EX) by influencing macrophage polarization in normal and inflammatory
environments in vitro.

Methods::
In this study, hucMSCs-conditioned medium (hucMSCs-CM) and hucMSCs-
EX were used to treat RAW264.7 macrophages with or without LPS. The expressions of TNF-
α, IL-10, IL-6, IL-1β, and Arg-1 were quantified by qPCR. The expressions of IL-6 and IL-10
were evaluated by ELISAs. Western blots (WB) were performed to observe the expressions of
CD206, NF-κB P65, NF-κB p-p65, p-STAT3, STAT3, and NF-κB phosphorylation. The number
of cells expressing CD206 and the fluorescence intensity were measured via flow cytometry
(FC) and immunofluorescence staining. Cell propagation and migration were examined via
MTT and transwell assays, respectively.

Results::
The inhibition of LPS-induced inflammatory polarization by hucMSCs-EX or hucMSCs-
CM led to increases in IL-10 and arginase (Arg) levels and decreases in those of IL-6 and
TNF-α. Moreover, hucMSCs-EX enhanced the CD206 expression in RAW264.7 cells and accelerated
the propagation and migration of LPS-induced cells. The suppressive impact of
hucMSCs-EX on the LPS-induced phenotypic polarization of M1 macrophages was linked
with the reduction of NF-κB signaling. They stimulated the transition of M2 macrophages by
enhancing the activity of STAT3 in RAW264.7 cells.

Conclusion::
This study indicated that hucMSCs-EX enhances the macrophage transition into
the M2 phenotype by inhibiting the NF-κB p65 axis and stimulating that of STAT3.
GPR56, an Adhesion GPCR with Multiple Roles in Human Diseases,
Current Status and Future Perspective
Authors: Fan Yan , Yan Xiao-Yan , Guan Wei 
Published: May 2024

:
Human G protein-coupled receptor 56 (GPR56) belongs to a member of the adhesion
G-protein coupled receptor (aGPCR) family and widely exists in the central nervous system and
various types of tumor tissues. Recent studies have shown that abnormal expression or dysfunction
of GPR56 is closely associated with many physiological and pathological processes, including
brain development, neuropsychiatric disorders, cardiovascular diseases and cancer progression.
In addition, GPR56 has been proven to enhance the susceptibility of some antipsychotics and
anticarcinogens in response to the treatment of neuropsychological diseases and cancer. Although
there have been some reports about the functions of GPR56, the underlying mechanisms implicated
in these diseases have not been clarified thoroughly, especially in depression and epilepsy.
Therefore, in this review, we described the molecular structure and signal transduction pathway of
GPR56 and carried out a comprehensive summary of GPR56's function in the development of
psychiatric disorders and cancer. Our review showed that GPR56 deficiency led to depressive-like
behaviors and an increase in resistance to antipsychotic treatment. In contrast, the upregulation of
GPR56 contributed to tumor cell proliferation and metastasis in malignant diseases such as
glioblastoma, colorectal cancer, and ovarian cancer. Moreover, we elucidated specific signaling
pathways downstream of GPR56 related to the pathogenesis of these diseases. In summary, our review
provides compelling arguments for an attractive therapeutic target of GPR56 in improving
the therapeutic efficiency for patients suffering from psychiatric disorders and cancer.