bluuebunny/crossref_metadata_2025_split huggingface dataset:
PW01-241 - The Effect Of Pregabalin On Subjective Sleep Problems During Withdrawal From Long-Term Benzodiazepine Use
Authors: Rubio G. , Bobes J. , Cervera G. , Terán A. , Perez M. , López-Gómez V. , Rejas J. 
Published: June 2010

ObjectiveTo evaluate the effect of pregabalin as a tapering therapy over the subjective sleep quality of patients who underwent a benzodiazepine withdrawal program.MethodThis was a secondary analysis of a 12-week, prospective, and observational study carried out in patients aged 18 years or over, who met DSM-IV-TR criteria for benzodiazepine dependence without other major psychiatry disorder. Evaluations included the Benzodiazepine Withdrawal Symptom Questionnaire, the Hamilton Anxiety Rating Scale, the Clinical Global Impression scale, and the MOS-Sleep Scale. Changes from baseline to the endpoint in the different scales’ scores as well as correlations of these changes with those of the MOS-Sleep scores were calculated.Results282 patients met the criteria for analysis. Mean pregabalin dose was 315 (166) mg/day at end-of-trial. We observed a significant and clinically relevant improvement in sleep outcomes at the study endpoint as measured with the MOS-Sleep Summary Index, that was reduced from 55.8 (18.9) pts at baseline to 25.1 (18.0) pts at week 12 (55% reduction), as well as with the six dimensions of the MOS-Sleep Scale. Moderate correlations were observed between Summary Index and sleep domains with improvements in the anxiety symptoms and in the disease severity as well. Also, sleep ameliorations were observed in the 52% successfully benzodiazepines withdrawals but, although to a lesser extent, in the remaining failures as well.ConclusionPregabalin treatment improves subjective sleep quality in patients who underwent a benzodiazepine withdrawal program and this effect appears partly independent of the improvement of anxiety or withdrawal symptoms.
PW01-242 - Risk Factors For Cocaine-Induced Psychosis In Cocaine Dependent Patients
Authors: Roncero C. , Daigre C. , Gonzalvo B. , Grau-López L. , Diáz-Morán S. , Eiroa F. , Sánchez L. , Resmella R. , Miquel L. , Comin M. , Casas M. 
Published: June 2010

IntroductionCocaine consumption can induce transient psychotic symptoms, expressed as paranoia or hallucinations. Cocaine induced psychosis (CIP) is common but not developed in all cases.ObjectivesTo describe the Risk Factors for developing cocaine-induced psychosis in cocaine dependent patients, according DSM-IV-TR criteria.MethodsThis is the first European study about the relationship of CIP with consumption pattern variables and personality disorders, we evaluated 220 cocaine dependents over 18 years, 80'5% males, mean age 33.9 years (SD = 7.6). Patients were recluted from an outpatient clinic department and subsequently systematically evaluated using SCID I and SCID II interviews for comorbidity disorders, and a clinical-based systematic psychotic symptoms form.ResultsA high proportion of cocaine dependent patients reported psychotic symptoms (51.8%) under influence of cocaine. The most frequent reported psychotic symptoms were paranoid beliefs and suspiciousness (42.4%). After a logistic regression analysis we found that a model consisted of high cocaine consumption (mean of 12.01 grams per week), cannabis dependence history and to use intranasal or smoked rout of administration had a sensitivity of 63.2% and a specificity of 70.2%.ConclusionWe conclude that is relevant to evaluate CIP in patients consuming high amounts of cocaine, with cannabis dependence history and who do not use intranasal rout. It could be useful for preventing consequences or risks of psychotic states for themselves or others.
PW01-243 - The Apomorphine Test As A Biological Marker For Relapse In Cocaine Dependent-Patients
Authors: Roncero C. , López-Ortíz C. , Rodríguez-Pascual M. , Corominas M. , Castells X. , Grau-López L. , Daigre C. , Gómez-Baeza S. , Castillo E. , Valero S. , Casas M. 
Published: June 2010

IntroductionUntil now, no reliable biological markers of risk and relapse in substance-dependent patients have been identified. The yawn-inducing test with apomorphine has been proposed as a marker of the functional status of the dopaminergic system and therefore a predictor of suffering an addiction or predisposition to relapse.ObjectivesStudying the safety and efficacy of apomorphine test as a predictor of relapse in intranasal cocaine dependent, diagnosed according to DSM-IV-TR.MethodsWe performed the test of apomorphine at the beginning (day 1) and end (day 11/12) of a detoxification program in 33 patients (29 men). The majority of patients relapsed after 22 weeks of follow up (87% relapse). The average yawns in the sample were 10.9 ± 9.3 in the initial test (Apo 1) and 10.2 ± 10.2 in the final test (Apo 2). The 42% of patients relapsed early (before 4 weeks) and 45% late (afther 4 weeks). 58% of the sample (N = 19), which did not fall belatedly filled an average of 8.0 yawns in Apo1 and 8.1 on Apo2 and 42% who did so early (N = 14), 14,8 in Apo1 and 14.6 in Apo2. Therefore there are an increased number of yawns in patients with early relapse. No important side effects were reported.ConclusionsPatients with early relapse have a higher number of yawns that those falling late or abstainers The apomorphine test is a safe test and it is a readily applicable tool in clinical practice and may be a biological marker of risk.
PW01-245 - Comparative Study of Psychological Health, Probability of Self-suicide Risk and Probability of Drugs Addition In University Students
Authors: Shafiei Amiri M. , Homayouni A. , Ahmadi T. 
Published: June 2010

IntroductionThe present research is designed and performed by the aim of comparative study of psychological health level, probability of drugs addiction in girl and boy university students.MethodsRandom sample includes 200 persons who 120 persons were girl and 80 persons were boy university students who were compared. All students, General health Questionnaire (GHQ) and Probability of Self-suicide and Probability of Drugs Addiction (PSSPDA) have been deducted from central office of science Ministry consultation questionnaire.ResultsIndependent T-test was used; Test results show that anxiety level, depression, physical complaints and disturbed social interaction is meaningfully greater more severe in girl university students than boy university students. Also, results showed that drugs addition in boy university students is meaningfully greater than in girl university students. Also, probability of self-suicide risk is meaningfully greater in girl university students than boy university students.DiscussionFindings indicated that most university students who embark to self-suicide or come to addict drugs, are worry about their educational improvement and situation and most persons who commit to self-suicide, are affected by emotional problems such as depression, anxiety and unpleasureable relationships, addiction to drugs and alcohol, unemployment, loneliness and guilt emotions. Therefore, it could be said that transfer nature of lives of most university students is accompanied by the experience of stress exposure for them. In this way, most students are accompanied by stress exposure experience. In this way, most university students come to addict drugs in order to decrease the stress.
PW01-248 - Topiramate as An Adjunct In Alcohol Detoxification Process
Authors: Paparrigopoulos T. , Tzavellas E. , Karaiskos D. , Papalias E. , Drabalos E. , Liappas I. 
Published: June 2010

BackgroundAnticonvulsants have been used for the treatment of affective and anxiety symptoms secondary to alcohol abuse as well as craving. In this open label study we investigated efficacy of topiramate as an adjunct in alcohol detoxification; end targets were anxiety, depression and in obsessive-compulsive drinking.MethodsTwo groups matched for age, alcohol consumption and demographic characteristics, were treated either with psychotherapy (n=43) or psychotherapy and topiramate (n=43). Subjects were assessed twice (baseline and after a 4-6 week detoxification period) by the Hamilton Anxiety Rating Scale, the Hamilton Depression Rating Scale, and the Obsessive Compulsive Drinking Scale. T-tests were used for comparisons between groups.ResultsFollowing detoxification, psychopathology significantly subsided in both groups; however, improvement was more robust in the topiramate group (table 1). HDRS admissionHDRS dischargeHARS admissionHARS dischargeOCDS admissionOCDS dischargeTopiramate group39.2 ± 4.26.7 ± 4.3*33.9 ± 6.45.5 ± 6.5*42.3 ± 3.28.2 ± 3.3*Control group38.7 ± 5.39.8 ± 7.4*32.3 ± 10.69.5 ± 6.5*41.5 ± 2.615.2 ± 2.4*[Table 1]DiscussionTopiramate in conjunction with a short-term psychotherapeutic approach may help the alcohol detoxification process by minimizing craving and subjective physical discomfort. Moderate to severe anxiety and depressive symptoms with concomitant poor functioning were present in all subjects before treatment. Following 4-6 weeks of alcohol detoxification, a considerable improvement in terms of anxiety and depressive symptoms was observed in both groups. However, in our sample, a significantly more robust decrease was recorded in the topiramate augmentation group. Consequently, topiramate can be of potential help in this population and can be used as an alternative among other treatment options.
PW01-255 - Suicide In Cinema
Authors: Guimaraes S. , Pereira S. 
Published: June 2010

IntroductionThe cinema has been fascinated by madness and its manifestations. Psychiatric illnesses have enabled filmmakers’ immense material for their screenplays, and the issue of suicide is often addressed.MethodsA literature search was made through research on Pubmed with the words “cinema and suicide”,”cinema and psychopathology”.Thirty five American and European films where the theme of suicide had been addressed were randomly selected from a cinema database (http://imdb.com). A questionnaire with data about the films screened was developed specifically for the study, which was filled to the extent that each film was viewed. The psychiatric diagnoses related with suicide were made according to DSM-IV-TR.DiscussionThe films selected deal with suicide in various ways, providing a more or less realistic overview about the mental disorder;The profile from the suicide was: caucasian male, mid aged (< 45 yrs), committing suicide with a violent method (mainly fire gun), suffering from a psychiatric disorder (depression, personality disorders, substance abuse) after a significant life event. Just a small proportion (11%) was in psychiatric treatment. This profile matches with real data from the literature.The characterization from the mental heath professionals was subjective coated as negative in the majority of the movies selected.ConclusionIt is important to reflect on the vision that the movies provide in the general public about suicide, mental disease and in which way they shape the perception about the mentally ill and those who treat them.
PW01-257 - Direct Costs Of Suicide Attempts In Basel, Switzerland
Authors: Czernin S. , Vogel M. , Bourgnon J.-C. , Muheim F. , Reichelt M. , Stoppe G. 
Published: June 2010

BackgroundSuicide is one of the major health problems today. The few available health economic studies have focussed on suicides. However suicide attempts, which are much more frequent, have been disregarded.MethodsWe made use of available data of the WHO-Euro-Multicentre study. During the year 2003, N=201 persons committing a suicide attempt in Basel could be accessed for health economic investigations. Due to the care structure in our region we started with the direct costs of inpatient treatment at the university (psychiatric) hospitals, which provide a wide majority of care for the people of the area, especially in emergency cases like suicide. Outpatient treatment was only calculated, if it was performed by these hospitals. This analysis included the overhead of the hospitals (staff etc.) was well as the costs provides for special services, consultation and liaison services, transports and emergency actions.ResultsWe assume that the direct costs make up only part of the total costs. For example the loss of working ability, health costs for family members, caregivers and friends affected are not included in our analyses. Against our assumption, we could not find major differences regarding the underling diagnoses. However, elderly suicide attempts were more costly. There were also gender differences. Further details will be discussed.ConclusionThe data show, that suicide attempts are expensive. Health care planers should take these data into account when discussing and deciding investments in suicide preventions.
PW01-259 - Paroxetine Use During Pregnancy and Adverse Pregnancy Outcomes In The Absence Of Detection Bias
Authors: Berard A. , Sheehy O. 
Published: June 2010

ObjectiveTo quantify the prevalence of adverse pregnancy outcomes associated with gestational exposure to paroxetine before the FDA warnings on the risk of cardiac malformations in newborns associated with the use of paroxetine during gestation were issued in 2005.MethodsData on all pregnancies included in the Quebec Pregnancy Registry were analysed to estimate the prevalence of planned/spontaneous abortions and deliveries during 1998-2004, before the warnings were issued. All study outcomes including congenital malformations are physician-based, and made prospectively and routinely as part of health care management; exposure to paroxetine is based on automated prescription fillings. Trends in the frequency of gestational use of paroxetine during the study period were compared to the trends in the prevalence of cardiac malformations.ResultsAmong the 109,344 eligible pregnancies, 1,612 (1.5%) were exposed to paroxetine. Amongst paroxetine users, 49% had a planned abortion, 7% a spontaneous abortion, and 44% a delivery. Amongst those who delivered, 3% had a baby with a cardiac malformation. The most prevalent cardiac malformations were atrial and ventricular septal defects (74%). During the study period, an increase in the prevalence of paroxetine use during pregnancy was correlated with an increase in the rate of cardiac malformations.ConclusionParoxetine use during gestation is associated with an important risk of adverse pregnancy events above baseline rates. Before the warnings on paroxetine were issued, the increase in the prevalence of paroxetine use during pregnancy was already correlated with an increase in the rate of cardiac malformations, excluding the possibility of detection bias.
SS01-01 - A New Way To Manage Depression Successfully: Restoring Circadian Rhythms
Authors: Racagni G. 
Published: June 2010

Depression is a complex disorder characterized by a disruption of brain functions and altered intracellular mechanisms. However, it is evident that none of the current hypotheses of depression (monoamine, hypothalamo-pituitary adrenal, and neuroplasticity), can explain all the effects of antidepressants. On the other hand, there is no doubt that each of these hypotheses affords important insights into the pathophysiology of depression.One hypothesis in particular is the object of an increasing body of evidence: the circadian rhythm hypothesis of depression is based on the fact that (i) depression is very often associated with a disruption of circadian rhythms, and (ii) the severity of depression is correlated with the disruption of circadian rhythms, suggesting that resetting the circadian rhythms may play a pivotal role in the treatment of depression.Agomelatine is the first melatonergic antidepressant acting as an MT1/MT2 melatonergic agonist and as a 5-HT2C antagonist whose efficacy has been proven in several animal models of depression and in patients with major depressive disorder. These receptors are mainly present in the suprachiasmatic nuclei, but also in the hippocampus, prefrontal cortex, and hypothalamus.Given the action of agomelatine through these receptors, it was important to establish to what extent agomelatine works through modulation or via synergic interaction between MT1/MT2 and 5-HT2C receptors. Recent data show that only agomelatine (not melatonin or a 5-HT2C antagonist) modulates the expression of neuroplastic genes (BDNF and Arc), suggesting that the intracellular events can be regulated through synergic activity between both melatonergic and 5-HT2C receptors.
YSW01-04 - Experiences From The First International Telepsychiatry Service In Europe: Patient Satisfaction Survey
Authors: Mucic D. 
Published: June 2010

International telepsychiatry service was established between Denmark and Sweden in order to increase access to cross-cultural expertise that was more readily available in Sweden. Video-conferencing equipment connected the Swedish department of the Little Prince Psychiatric Centre with two hospitals, one asylum seekers’ centre and one social institution, at four different places in Denmark. Over a period May 2006-October 2007, 30 patients were treated by telepsychiatry (21 men and 9 women). After the end of the telepsychiatry contact all patients were asked to complete a satisfaction questionnaire.The patients reported a high level of acceptance and satisfaction with telepsychiatry, as well as a willingness to use it again or recommend it to others. Patients expressed a wish to use telepsychiatry via their mother tongue, rather than through an interpreter in the future.Mental health services in Scandinavia face significant resource shortages that may result in functional gaps. There is no doubt that mentally ill asylum seekers, refugees and migrants are under-served in their mother tongue. Telepsychiatry can ease the access to scarce resources and improve the quality of care. Presented service is the first international telepsychiatry collaboration to be established in Europe. The results of the survey may contribute to changes in policy and routines within mental health services towards cross-cultural patient population not only in Denmark but also in the rest of the EU.
YPSP01-01 - Clinical Typology Of Depression Among Patients Of Hospice And Nurse Care Department
Authors: Shakhurova N. 
Published: June 2010

ObjectiveTo compare the characteristics of the typology and frequency of depressive disorders in elderly patients of nursing care department and hospice.Materials and methodsTwo groups of the patients:- 1) 49 persons (19 male and 30 female, mean = 73,17±7,13 yrs) hospitalized due to incurable oncopathology for palliative care in the hospice and 2) 101 patients of the nurse care department (19 male and 82 female, mean = 75,21 ± 8,2 yrs) with complex combined somatic pathology, being in the hospital with necessity of assistance rendering or validation of medical documents into nursing home - were questioned according to Hospital Anxiety and Depression Scale (HADS) and Geriatric Depression Scale (GDS-15). The inclusion criterions were the ability to understand the text of the questionnaire and the wish to answer to one.Resultsthe depressive disorders have been detected to 65,3% patients of the first group and to 69,39% patients of second group. Comparative analysis of affective disorders prevalence has shown a statistically significant data on a more frequent occurrence of recurrent depressive disorder in patients with oncological diseases, whereas patients with other somatic pathology were more frequently determined by the organic affective disorder (p = 0,00593).ConclusionsPerformed investigation has shown a high incidence of disorders of depressive spectrum in elder patients of palliative care hospital. Screening revealing of depressive disorders reaches important aims such as objectification of clinical diagnosis of mental status and efficacy of psychopharmacotherapy, promotes more empathic response of secondary staff to emotional needs of incurable patient.
YPSP01-04 - Training On How To Use The Intermed: The Experience At Modena Medical School
Authors: Zannoni E. , Bombi A. , Bonati A. , Delli Carri T. , Disavoia A. , Ferrari S. , Mazzali V. , Simoni E. , Ferri P. , Huyse F.J. , Rigatelli M. 
Published: June 2010

ObjectivesINTERMED is an instrument to assess bio-psycho-social case complexity in general health care by focusing on past, present and future health needs and risks of patients. It consists in a structured interview defining 20 variables and related anchor points. The total score ranges from 0 to 60, reflecting the level of complexity and the related care needs/risks. The aim of this work was to describe the training process on the use of INTERMED and to assess its effectiveness.MethodsA training group of 9 subjects had two-hour meetings twice a month between April and September 2009. After introductory sessions on theoretical aspects and inter-trainee simulations on interviewing and scoring techniques, students were assigned the task of producing video-recorded clinical material, which was used to comment on interviewing skills and practice on scoring. Individual and consensus scores were collected at the beginning and at the end of the training and compared statistically by means of Cohen's kappa.ResultsMotivation and involvement of students in the training was high (participation was on a voluntary basis during extra-work hours), as satisfaction. Agreement between individual and consensus scores was high already at the beginning of the training (Cohen's kappa mean value of 0.80) and slightly improved during the course.ConclusionsThe training process gave positive results both on the quantitative and the qualitative sides of evaluation. A six-month 25-hour training period is a reasonable time for learning how to master the instrument, although it needs to be followed by the clinical practice.
YPSP01-12 - Lipid Metabolism Changes After Switching To Ziprasidone
Authors: Dragasek J. , Palova E. , Lukacsova I. , Drimalova M. , Breznoscakova D. , Mirossay P. 
Published: June 2010

IntroductionIncreasing numbers of reports concerning lipid dysregulation, diabetes and hyperglycaemia in patients treated with atypical antipsychotics have raised concerns about a possible association between these metabolic effects and treatment with these medications.ObjectivesThe available literature notes that ziprasidone is a weight-neutral antipsychotic and that lipids anomalies improve when patient are switched from other atypical antipsychotics to ziprasidone.AimsThe purpose of this study was to examine the association of treatment with ziprasidone and changes in serum levels of cholesterol, triglycerides, serum levels of glucose and BMI changes.MethodsProspective, cohort, multicenter, open design in 373 in- and outpatients treated with ziprasidone for broad spectrum of psychotic disorders in flexible dose manner. The analysis was done in group of patients with no previous antipsychotic treatment or discontinuation of antipsychotic treatment longer than 3 months compared to group of patients directly switched from another antipsychotic treatment to ziprasidone.ResultsChanges in fasting serum levels of total cholesterol were significant from baseline at week 24 in subgroup of patients directly switched from another antipsychotic treatment to ziprasidone (5,12 vs 4,94 mmol/l, p< 0,05, ANOVA).ConclusionsWe have observed statistical significant difference in fasting serum levels of total cholesterol in patients directly switched from another antipsychotic treatment to ziprasidone.