bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Outcome of Dental Implants Placed with High Insertion Torques (Up to 176 Ncm)
Authors: Khayat Philippe G. , Arnal Hélène M. , Tourbah Bahige I. , Sennerby Lars 
Published: May 2011

ABSTRACTBackground: Primary stability can be improved by using a tapered implant in a slightly underprepared implant site. This may lead to high compression forces and elevated insertion torques. It has been postulated that disturbance of the local microcirculation may occur, leading to necrosis of the osteocytes and bone resorption.Purpose: Report on the clinical outcome of 42 implants placed with an insertion torque equal or greater than 70 Ncm and evaluate bone levels around these implants.Materials and Methods: This prospective study included 48 patients treated with 66 4.5 mm diameter Tapered Screw‐Vent implants (Zimmer Dental®, Carlsbad, CA, USA). Maximum insertion torque (MIT) was recorded with an electronic torque measuring device (Tohnichi® STC200CN, Hitachi, Tokyo, Japan).Nine implants (control group) presented MIT between 30 and 50 Ncm (mean = 37.1 Ncm) and 42 implants (experimental group) MIT greater than 70 Ncm (mean = 110.6 Ncm, range: 70.8–176 Ncm). Marginal bone levels were recorded at the time of loading and 1 year later for the two groups.Results: After 2–3 months of non‐sumerged healing, all implants were clinically stable. Mean marginal bone resorption was 1.03 mm (SD = 0.44) for the control group (low torque) and 0.72 mm (SD = 0.56) for the experimental group (high torque) at time of loading, and 1.09 (SD = 0.62) and 1.24 mm (SD = 0.75), respectively, after 1 year. There were no significant differences between the two groups for bone stability and implant success rate.Conclusions: The use of high insertion torques (up to 176 Ncm) did not prevent osseointegration. Marginal bone levels in the control and experimental groups were similar both at the time of loading and 1 year later.
Candida albicans biofilm formation on soft denture liners and efficacy of cleaning protocols
Authors: Hahnel Sebastian , Rosentritt Martin , Bürgers Ralf , Handel Gerhard , Lang Reinhold 
Published: May 2011

doi: 10.1111/j.1741‐2358.2011.00485.x

Candida albicans biofilm formation on soft denture liners and efficacy of cleaning protocolsObjective:  The aim of this study was to investigate Candida albicans biofilm formation on denture liners and to analyse the efficacy of cleaning protocols.Material and methods:  Specimens were prepared from four silicone‐based soft denture liners. After artificial ageing and surface free energy determination, specimens were incubated with saliva (2 h) and Candida albicans ATCC 10231 for either short‐ (2.5 h) or long‐term (24 h) biofilm formation. Adherent cells were determined either after incubation of specimens with Candida albicans or after treatment with different denture cleaning protocols. Statistical analysis was performed using one‐way anova and the Games–Howell test (α = 0.05).Results:  For both short‐ and long‐term biofilm formation, similar amounts of Candida albicans cells were found on the surface of the different liners (p = 0.295 and 0.178, respectively). For both short‐ and long‐term biofilm formation, the highest cleaning efficacy was observed for sodium hypochlorite (NaOCl; p < 0.01). The efficacy of the chemical denture cleaner in removing long‐term Candida albicans biofilms was significantly lower than the efficacy of removal by brushing (p < 0.001).Conclusion:  Different silicone‐based soft denture liners yield similar Candida albicans biofilm formation on their surface. The highest efficacy for the removal of Candida albicans biofilms was identified for NaOCl. Chemical denture cleaners appear to have rather low efficacy to remove mature Candida albicans biofilms.
How do we apply adjuvant FOLFOX to Japanese patients with curatively resected colorectal cancer?
Authors: SUENAGA Mitsukuni , MATSUSAKA Satoshi , WATANABE Toshiyasu , KUBOKI Yasutoshi , SHINOZAKI Eiji , CHIN Keisho , MIZUNUMA Nobuyuki , UENO Masashi , YAMAGUCHI Toshiharu , HATAKE Kiyohiko 
Published: May 2011

AbstractAim:  In Japan the combination of fluorouracil (5‐FU), leucovorin and oxaliplatin (FOLFOX) was approved as adjuvant therapy for stage III or high‐risk stage II colon cancer only in September 2009. In this study we evaluated the safety and efficacy of FOLFOX as adjuvant chemotherapy for stage IIIb or IV colorectal cancer (CRC) patients in a Japanese group at a single institute.Methods:  A total of 45 consecutive patients received 12 cycles of adjuvant FOLFOX for stage IIIb (n = 31) or IV (n = 14) CRC. Toxicity and disease‐free survival (DFS) were analyzed retrospectively.Results:  The median dose intensities of oxaliplatin and 5‐FU were 0.7 and 0.74, respectively. Oxaliplatin was discontinued in 10 (22%) patients due to an allergic reaction in five, neurotoxicity in four and gastrointestinal toxicity in one. No severe neurotoxicity occurred. The median duration from completion of treatment until complete recovery from peripheral neuropathy was 582 days (95% CI, 486–678). Two‐year DFS for stages IIIb and IV was 56.9% and 56.3%, respectively (log–rank, P = 0.533). Univariate analysis revealed that severe vessel invasion, liver metastasis and higher baseline levels of CA19‐9 were associated with shorter DFS in stage IV patients. Multivariate analysis including the selected biomarkers revealed none as a significant prognostic factor.Conclusion:  Adjuvant FOLFOX was well tolerated in a Japanese cohort of both stage IIIb and IV CRC patients.
Changes in medical oncology admissions for the management of breast cancer complications: An Australian institution's experience
Authors: DAY Fiona L , BULL James M , LOMBARD Janine M , STEWART John F 
Published: May 2011

AbstractAims:  There is a scarcity of data regarding medical hospitalizations for breast cancer. The aim was to determine whether the burden of inpatient care for breast cancer was declining.Methods:  A retrospective study was conducted of all admissions to a single medical oncology inpatient unit in 1996 and 2006 related to the treatment of breast cancer. The total number of hospitalizations, patients' length of stay in hospital, clinical indications for hospitalization and utilization of inpatient services were determined. Data analysis involved pairwise comparisons between the cohorts.Results:  The total number of breast cancer hospitalizations was similar in 1996 and 2006. However, the number of hospitalizations for adjuvant treatment complications was 50% lower in 2006, attributable to a lower rate of chemotherapy‐associated febrile neutropenia. Acute clinical problems necessitating inpatient care differed between 1996 and 2006. Fewer hospitalizations for symptomatic hypercalcemia, uncontrolled pain and chemotherapy toxicity were required in 2006 but a significant increase was seen in central nervous system complications. Recent practice involved greater inpatient consultation of other medical and surgical teams. There was a trend towards a shorter duration of admissions in 2006 in both adjuvant and metastatic patients.Conclusion:  Although total annual breast cancer admission numbers and length of stay did not change significantly, hospitalization for treatment‐related complications was less frequent in 2006. The clinical manifestations of metastatic breast cancer appear to be changing, and in our institution are being managed with broader multidisciplinary care.
Efficacy of bevacizumab with cisplatin and gemcitabine in Asian patients with advanced or recurrent non‐squamous non‐small cell lung cancer who have not received prior chemotherapy: A substudy of the Avastin in Lung trial
Authors: MOK Tony SK , HSIA Te‐Chun , TSAI Chun‐Ming , TSANG Kenneth , CHANG Gee‐Chen , CHANG John Wen‐Cheng , THITIYA Sirisinha , SRIURANPONG Virote , THONGPRASERT Sumitra , CHUA Daniel TT , MOORE Nicola , MANEGOLD Christian 
Published: May 2011

AbstractAim:  The phase III AVAiL study evaluated the efficacy and safety of the anti‐vascular epidermal growth factor agent bevacizumab combined with platinum‐based chemotherapy as first‐line treatment in patients with advanced non–small‐cell lung cancer (NSCLC). We report the results of a preplanned analysis of Asian patients enrolled in AVAiL.Methods:  Patients with recurrent or advanced non‐squamous NSCLC were randomized to receive bevacizumab 7.5 mg/kg, bevacizumab 15 mg/kg or placebo, plus cisplatin 80 mg/m2 and gemcitabine 1250 mg/m2 for up to six cycles, followed by bevacizumab or placebo until disease progression. An exploratory analysis was undertaken to assess efficacy and safety in an Asian subgroup.Results:  Of the 1043 patients enrolled, 105 were Asian and were included in the subgroup analysis. Progression‐free survival was 8.5 months (95% CI 7.3–10.8) in the bevacizumab 15‐mg/kg group, 8.2 (95% CI 6.6–11.7) in the 7.5‐mg/kg group and 6.1 (95% CI 5.1–8.0) in the placebo group. Median overall survival in the 7.5‐mg/kg bevacizumab group was prolonged compared with placebo group (HR 0.46; 95% CI 0.22–0.97). Nausea was the most common adverse event, occurring at similar rates (ranging from 69–76%) in all study groups. Hypertension was the most common adverse event of special interest, seen in 29, 55 and 16% of patients in the 7.5‐mg/kg and 15‐mg/kg bevacizumab and placebo groups, respectively.Conclusion:  Study results strongly suggest that bevacizumab at a dose of 7.5 mg/kg improves the duration of overall survival when combined with cisplatin‐gemcitabine in Asian patients. Bevacizumab was well tolerated in this patient group.
Cost‐effectiveness of bevacizumab‐based therapy versus cisplatin plus pemetrexed for the first‐line treatment of advanced non‐squamous NSCLC in Korea and Taiwan
Authors: AHN Myung‐Ju , TSAI Chun‐Ming , HSIA Te‐Chun , WRIGHT Elaine , CHANG John Wen‐Cheng , KIM Heung Tae , KIM Joo‐Hang , KANG Jin Hyoung , KIM Sang‐We , BAE Eun‐Jin , KANG Mijeong , LISTER Johanna , WALZER Stefan 
Published: May 2011

AbstractAims:  The aim of this analysis is to investigate the mean incremental costs and life expectancy associated with two first‐line treatments for advanced non‐squamous non‐small cell lung cancer (NSCLC) in Korea and Taiwan; bevacizumab plus cisplatin and gemcitabine (BevCG) and cisplatin plus pemetrexed (CP).Methods:  A health economic (area under curve) model with three health states was developed to assess health outcomes (life‐years gained [LYG]), direct costs, and incremental cost‐effectiveness ratio (ICER). Progression‐free survival (PFS) and overall survival (OS) were derived from randomized clinical trials and used in an indirect comparison in order to estimate their cost effectiveness. A life‐time horizon was used. Costs and outcomes were discounted yearly by 5% in Korea and by 3% in Taiwan.Results:  The incremental LYG for the BevCG patients compared with patients treated with CP were 1.10 (13.2 months) in Korea and 1.19 (14.3 months) in Taiwan. The incremental costs were 37 439 968 ($33 322) in Korea and NT$1 910 615 ($64 541) in Taiwan. The incremental cost‐effectiveness ratio was 34 064 835 ($30 318) in Korea and NT$1 607 960 ($54 317) in Taiwan. The inputs tested in one‐way sensitivity analyses had very little impact on the overall cost effectiveness.Conclusion:  This analysis shows that BevCG is more costly but is also associated with additional life‐years in Korea and Taiwan. The ICER per LYG suggests that BevCG is a cost‐effective therapy when compared to CP for patients with advanced NSCLC in Korea and Taiwan.
Role of Multifunctional Cell Cycle Modulators in Advanced Secondary Hyperparathyroidism
Authors: Sato Tetsuhiko , Kikkawa Yamato , Hiramitsu Takahisa , Yamamoto Takayuki , Goto Norihiko , Matsuoka Susumu , Nagasaka Takaharu , Watarai Yoshihiko , Uchida Kazuharu , Tominaga Yoshihiro 
Published: May 2011

AbstractLong‐term dialysis for patients with end stage renal disease leads to an unavoidable common complication, which is secondary hyperparathyroidism. Two histological patterns (nodular and diffuse hyperplasia) are detected, indicating that continuous uremia‐related stimulation promotes parathyroid cell proliferation from diffuse to nodular growth. However, the key molecular mechanism is not fully understood, which narrows the range of therapeutic options for advanced secondary hyperparathyroidism. To address this issue, we utilized surgically resected normal and hyperplastic parathyroid glands to perform immunohistochemical analysis of a multifunctional cell cycle modulator, CCAAT enhancer binding protein (C/EBP)β. In contrast to normal parathyroid tissue and diffuse hyperplasia, the intensity of C/EBPβ staining was homogeneously increased in the parathyroid cells from nodules, along with a higher cyclin D1 labeling index (108.0 ± 19.5, mean ± SEM) and Ki‐67 labeling index (31.70 ± 0.49). Normal and diffuse hyperplastic parathyroid glands had far fewer cyclin D1‐ and Ki‐67‐positive cells (P < 0.001). Immunofluorescent double staining showed abundant coexpression of Th235 (mitogen‐activated protein kinase [MAPK] phosphorylation site) C/EBPβ, along with upregulation of cytoplasmic Ras in nodular hyperplasia. In conclusion, hyperplastic parathyroid cells in nodules have an autonomous proliferation mechanism similar to that of cancer, in which C/EBPβ is upregulated and phosphorylated to interact with the oncogenic Ras/MAPK pathway. C/EBPβ may be a novel target molecule for blocking the growth circuit that underlies parathyroid tumorigenesis in secondary hyperparathyroidism.
Three staphylinid species (Coleoptera: Staphylinidae) in South Korea
Authors: PARK Jong‐Seok , KIM Yoon‐Ho , AHN Kee‐Jeong 
Published: May 2011

AbstractThree staphylinid species, Aleochara (Aleochara) coreana Bernhauer, A. (Coprochara) verna Say and Prosthecarthron sauteri Raffray, are recorded for the first time from South Korea. Redescriptions and line drawings of diagnostic characters of all three species are provided. Ecological notes are provided for P. sauteri.
Effect of modified meridic diet on the development and growth of tomato fruitworm Helicoverpa armigera (Lepidoptera: Noctuidae)
Authors: WAKIL Waqas , GHAZANFAR M. Usman , SAHI Shahbaz Talib , KWON Yong Jung , QAYYUM M. Abdul 
Published: May 2011

AbstractThe efficacy of one new modified and two old meridic diets on Helicoverpa armigera Hübner (Lepidoptera: Noctuidae) for rearing six successive generations was studied. Duration of larval development for insects fed on the modified diet was considerably shortened as most of them went through only five stadia before pupation, while the per cent pupation and per cent eclosion were relatively higher than on other diets. The lowest pupal mortality (6.33 ± 0.13%) was recorded in the F1 generation reared on the modified diet, whereas the highest pupal mortality (19.49 ± 0.15%) was observed in insects reared on a natural diet in the F6 generation. Blending of chickpea Cicer arietinum L. and red kidney bean Phaseolus vulgaris L. flours with tomato paste proved highly favorable for adult reproduction. These results suggest that the vitality of the tomato fruitworm did not decline obviously after rearing on a modified diet for several generations.
Saltiness Enhancement by Savory Aroma Compounds
Authors: Batenburg Max , van der Velden Rob 
Published: May 2011

Abstract:  The impact of elevated levels of complex savory flavorings and single aroma compounds on perceived saltiness was investigated. This study demonstrates that multisensory interaction between aroma and taste can be employed to compensate for the lower salt levels of healthier food products without disturbing the overall flavor pattern. The demonstrated saltiness enhancement by the savory flavorings was unraveled by experiments with “salt‐congruent” single aroma compounds, using trained and naïve panels. Several savory compounds, of different chemical classes and different sensory impact, could be identified as key salt‐enhancing compounds, providing a significant increase of perceived saltiness. As expected, an untrained, naïve panel appeared more suitable to demonstrate multisensory saltiness enhancement due to its synthetic attention than a trained descriptive panel. The salt enhancement results were confirmed by consumer tests. The extra aroma was also found to ameliorate the off‐flavor of potassium‐based salt replacers, and combinations of extra aroma and salt replacers could replace significant amounts of sodium chloride while keeping the original flavor profile intact.Practical Application:  The food industry is under high pressure to significantly reduce the salt levels in their products. This study shows that it is possible to compensate salt reduction in instant bouillons by higher levels of savory aroma. A combination of potassium chloride based salt replacer and extra aroma was found to compensate approximately 30% sodium reduction without significant change of the flavor profile.
Epidemiology and Clinical Features of Human Infection with Coxiella burnetii in Denmark During 2006–07
Authors: Bacci S. , Villumsen S. , Valentiner‐Branth P. , Smith B. , Krogfelt K. A. , Mølbak K. 
Published: May 2011

SummaryQuery (Q) fever was virtually unknown in Denmark in 2005, when, after the introduction of new sensitive diagnostic methods for Coxiella burnetii, an increasing number of positive cattle created concern among people with frequent exposure. This led to a dramatic rise in examinations for Q fever among humans in the following 2 years. The aim of our study was to assess indication for testing and symptoms in individuals with serological signs of infection with C. burnetii. We performed a case‐review study of seropositives among all humans tested for Q fever in 2006–07 in Denmark. Seropositive cases were categorized with acute infection: 4‐fold increase in immunoglobulin G (IgG) phase II or concomitant IgM phase II ≥ 1 : 256 and IgG phase II ≥ 1 : 1024; and previous infection: IgG phase II ≥ 1 : 1024. A borderline result was defined as: IgG phase II = 1 : 512. Physicians completed a questionnaire retrospectively. Of the 1613 people tested, 177 (11%) were seropositive [37 (2%) acute infection, 140 (9%) previous infection], 180 had a borderline result. Among 127 seropositives responders, 31% were tested due to symptoms compatible with Q fever after a possible exposure to C. burnetii, 64% were asymptomatic and were tested following relevant exposure only; 64% were males, 43% farmers, 39% veterinarians, 84% had been exposed to cattle. The most frequently reported symptoms were asthenia (25%), myalgia (21%), fever (17%) and headache (13%). About two‐thirds of seropositives reported asymptomatic infections, and were tested for Q fever because of concern for occupational exposure to cattle. One‐third of the seropositives reported symptoms consistent with Q fever, the majority being mild. Our study provided important evidence that increased requests for Q fever testing in 2006–07 arose from heightened public awareness of the disease, and not from an outbreak of clinical disease. Nonetheless, Q fever should be considered endemic in Denmark.
Species-Specific Interactions of Src Family Tyrosine Kinases Regulate
Chlamydia
Intracellular Growth and Trafficking
Authors: Elwell Cherilyn A. , Kierbel Arlinet , Engel Joanne N. 
Published: May 2011

ABSTRACT

Src family kinases (SFKs) regulate key cellular processes and are emerging as important targets for intracellular pathogens. In this commentary, we briefly review the role of SFKs in bacterial pathogenesis and highlight new work on the role of SFKs during the intracellular cycle of
Chlamydia
species.
Work disability benefits due to musculoskeletal disorders among Brazilian private sector workers
Authors: Vieira E R , Albuquerque-Oliveira P R , Barbosa-Branco A 
Published: May 2011

ObjectiveTo evaluate the prevalence and characteristics of disability benefits due to musculoskeletal disorders (MSD) granted to Brazilian private sector workers.MethodsThis was a population-based epidemiological study of MSD-related benefits among registered private sector workers (n=32 959 329). The prevalence (benefits/10 000 workers/year) of work disability benefits was calculated by gender, age, state, Human Development Index (HDI), economic activity, MSD type and work-relatedness.ResultsThe prevalence of MSD-related benefits in Brazil among registered private sector workers in 2008 was 93.6/10 000 workers. The prevalence increased with age, and was higher for women (112.2) than for men (88.1), although the former had shorter benefit duration. The gender-adjusted prevalence by state varied from 16.6 to 90.3 for non-work-related, and from 7.8 to 59.6 for work-related benefits. The Brazilian states with a high–very high HDI had the highest prevalence. The top four most common types of MSD-related benefits were due to back pain, intervertebral disc disorders, sinovitis/tenosynovitis and shoulder disorders.ConclusionMSD is a frequent cause of work disability in Brazil. There were differences in prevalence among economic activities and between states grouped by HDI. This study demonstrates that further evaluation of the contributing factors associated with MSD-related disability benefits is required. Factors that should be considered include production processes, political organisation, socioeconomic and educational characteristics, the compensation and recording systems, and employee–employer power relationships. These factors may play an important role in the prevalence of MSD-related disability benefits, especially in countries with large socioeconomic iniquities such as Brazil.
Histological characteristics predisposing to development of hepatocellular carcinoma in patients with chronic hepatitis B
Authors: Lee Sae Hwan , Chung Young-Hwa , Kim Jeong A , Jin Young-Joo , Park Won Hyung , Choi Jong Gi , Lee Danbi , Shim Ju Hyun , Yu Eunsil , Jang Myoung Kuk 
Published: May 2011

AimsLongstanding liver inflammation leads to hepatic regeneration and fibrosis, which subsequently progresses to cirrhosis in some patients with chronic hepatitis B virus (HBV) infection. It remains unclear, however, if the histological severity of chronic hepatitis B (CHB) may determine the development of hepatocellular carcinoma (HCC). The aim of this study was to evaluate the effects of necroinflammation and fibrosis at presentation of CHB on the development of HCC.MethodsMedical records and radiographs of 796 biopsy-confirmed CHB patients were reviewed retrospectively for a median period of 107 months (6–218) (median age 34 years (18–64), male:female 636:160). Eighty-five per cent (680/796) of patients were treated with antiviral agents such as interferon alpha and/or lamivudine. All the patients were followed at a regular interval of 3–6 months with routine laboratory tests. Abdominal imagings together with serum alpha-fetoprotein were checked every 6–12 months to detect new HCC. Necroinflammation and fibrosis were assessed semiquantitatively. Univariate and multivariate analyses were performed to identify significant risk factors for HCC.ResultsHCC developed in 3.4% (27/796) of patients during follow-up. The overall cumulative occurrence rates of HCC were 0.5% and 3.5% at 5 and 10 years, respectively. In multivariate analysis, age over 40 years (p<0.001), advanced fibrosis (p=0.006) and severe lobular activity (p=0.038) at presentation were independent risk factors for the development of HCC.ConclusionAdvanced fibrosis and severe lobular activity rather than porto–periportal activity on histology at presentation of CHB are independent predisposing risk factors for the development of HCC.