bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN SUPLEMEN BAHAN AJAR CARA-CARA ISOLASI DAN IDENTIFIKASI SENYAWA BAHAN ALAM DENGAN PENDEKATAN STEM’S BERBASIS ANDORID
Authors: Krisandini Triana , Sundaryono Agus , Elvia Rina 
Published: June 2024

Penelitian ini bertujuan untuk mengetahui tingkat kelayakan, respon mahasiswa terhadap suplemen bahan ajar bahan ajar Kimia Organik Bahan Alam (KOBA KIM 413, KD 2) dengan pendekatan STEM’S bebasis android dan hasil belajar mahasiswa setelah menggunakan suplemen bahan ajar tersebut. Penelitian ini dilaksanakan pada bulan Februari-Juli 2020. Model yang digunakan pada penelitian pengembangan ini adalah ADDI (adaptasi dari model ADDIE) yang terdiri dari tahap analisis, perencanaan, pengembangan, penerapan. Penelitian ini dilakukan di Univeristas Bengkulu dengan subjek mahasiswa pendidikan kimia Universitas Bengkulu yang mengambil mata kuliah KOBA TA 2019/2020. Mahasiswa dengan NPM genap berjumlah 9 orang untuk uji coba skala kecil dan mahasiswa dengan NPM ganjil berjumlah 21 orang untuk uji coba skala besar. Instrumen penelitian yang digunakan berupa angket kebutuhan, lembar validasi, angket respon, serta lembar evaluasi. Hasil penelitian ini diperoleh: (1) tingkat kelayakan suplemen bahan ajar dengan pendekatan STEM’S berbasis android, persentase kelayakan dari segi materi yang didapat yaitu 92,86 % dengan kategori sangat layak sedangkan dari segi media yaitu 80,21 % dengan kategori sangat layak sehingga bahan ajar dinilai layak untuk diujicobakan; (2) Hasil uji coba skala kecil didapatkan respon baik dengan persentasi rata-rata 89,75% dengan ada perbaikan; (3) Hasil belajar mahasiswa setelah menggunakan suplemen bahan ajar KOBA didapatkan nilai rata-rata sebesar 57,3 yang masuk pada kategori lulus. sehingga dapat disimpulkan bahwa suplemen bahan ajar cara-cara isolasi dan identifikasi senyawa bahan alam dengan pendekatan STEM’S bebasis android yang telah dikembangkan dapat digunakan sebagai suplemen dalam proses pembelajaran KOBA.
MENINGKATKAN KEMAMPUAN BAHASA MELALUI METODE BERCERITA KELOMPOK USIA 4-5 TAHUN DI TKIT SULTAN JAKARTA UTARA
Authors: Anggrayni Rice , Mamba'usa'adah Muna Sovia , Rahayu Siti , Yunitasari Septiyani Endang 
Published: June 2024

Kemampuan bahasa yang rendah pada anak usia 4-5 tahun TKIT Sultan Jakarta Utara menjadi latar belakang dari penelitian ini. Tujuan penelitian adalah meningkatkan kemampuan bahasa dengan metode bercerita pada kelompok usia 4-5 tahun di TKIT Sultan Jakarta Utara. Subjek penelitian ini yaitu anak usia 4-5 tahun (Kelompok A) TKIT Sultan tahun ajaran 2022/2023. Penelitian Tindakan Kelas (PTK) dua siklus digunakan dalam desain penelitian. Teknik pengumpulan data melalui observasi dan dokumentasi. Teknik analisis data yang digunakan adalah metode deskriptif komparatif yaitu membandingkan hasil antar siklus. Hasil penelitian pada pra tindakan diperoleh persentase sebesar 47% dilanjut dengan siklus I sebesar 60% dan pada siklus II persentase indikator keberhasilan tindakan menjadi 81%.
Kata Kunci: Kemampuan Bahasa; Metode Bercerita; Kelompok Usia 4-5 Tahun
Development of "My Bank" Media to Improve Beginning Mathematics Ability of 5-6 Years Old Children
Authors: Amelia Zahrina , Bustan Radhiya , Mailani Liana , Nurfadilah Nurfadilah 
Published: June 2024

Pengenalan berbagai aspek perkembangan salah satunya perkembangan matematika permulaan sangat penting bagi anak usia 5-6 tahun. Pada kenyataannya saat ini matematika diangap sebagai hal yang sulit untuk dipelajari dan membosaan. Media dalam mengenalkan matematika khususnya bagi anak usia dini saat ini lebih banyak menggunakan lembar kerja dan tidak mengenalkan secara nyata bilangan-bilangan dalam matermatika permulaan. Tujuan dalam penelitian ini adalah pengembangan media “BANK-KU” dalam mengenalkan matematika permulaan bagi anak. Metode yang digunakan dalam penelitian ini yaitu ADDIE (Analysis, Design, Development, Implementation, Evaluation). Berdasarkan hasil penelitian pada analisis kinerja yaitu kurang tersedia media interaktif dalam pengenalan matematika permulaan. Pada analisis kebutuhan berdasarkan hasil observasi dan wawancara menunjukkan rendahnya minat anak dalam pengenalan matematika permulaan khususnya berhitung. Melalui hasil tersebut maka dibuat desain media “BANK-KU” yaitu pengenalan konsep bilangan, ganjil genap, penjumlahan sederhana sencara nyata. Setelah melakukan perancangan media tersebut di validasi oleh pakar materi dan media. Masukan dari kedua pakar diperbaiki dan selanjutnya pelaksanaan implementasi, dalam implementasi pada 11 anak terlihat dapat menggunakan media dalam pengenalan bilangan satuan, puluhan, ratusan sampai dengan ratusan, pengenalan ganjil genap, pengenalan penjumlahan sederhana. Terdapat beberapa kendala dalam implementasi yaitu buku panduan yang memerlukan pengembangan dan ratio jumlah anak dalam penggunaan media BANK-KU
Stimulasi Membaca Permulaan pada Anak Usia Dini dengan Menggunakan Flash Card Digital
Authors: Novianti Rahmah , Pratiwi Niken 
Published: June 2024

Perkembangan bahasa sangat penting bagi anak usia dini karena melalui bahasa anak dapat berkomunikasi dan berinteraksi dengan orang-orang di lingkungan sekitarnya. Salah satu kemampuan dari perkembangan bahasa yaitu kemampuan membaca permulaan. Penelitian ini mempunyai tujuan untuk mengembangkan media untuk kegiatan membaca permulaan dengan menggunakan media digital yang berupa flash card sebagai bentuk stimulasi kemampuan membaca permulaan anak usia dini. Jenis penelitian ini merupakanpenelitian pengembangan yang menggunakan model ADDIE. Metode yang digunakan untukmengumpulkan data yaitu observasi dan instrumen. Data penelitian ini dianalisis secara deskriptif kuantitatif. Hasil penelitian menunjukkan dari ahli materi bahwa nilai yang didapatkan yaitu sebesar 84% dan ahli media 86%. Berdasarkan hal tersebut, media digital yang berupa kartu kata yang layak untuk diujicobakan dalam kegiatan pembelajaran anak usia dini. Implikasi penelitian ini flash card digital dapat digunakan oleh guru dalam proses pembelajaran.
Aplikasi Teknik Identifikasi Organisme Pengganggu Tanaman dan Teknologi Pembuatan Biopestisida sebagai Upaya Pemanfaatan Tanaman Sekitar dan Produksi Pertanian yang Berkelanjutan
Authors: Rahmawati Noor , Dewi Mustika , Kandar Mamat 
Published: June 2024

Pertanian berkelanjutan selalu memanfaatkan bahan alam dan menghindari penggunaan bahan sintetik dalam upaya peningkatan produksi pertanian, tanpa merusak lingkungan. Petani desa cinanjung kecamatan Tanjungsari kabupaten Sumedang, adalah petani hortikultura konvensional yang sebagain besar belum paham mengenai konsep pertanian berkelanjutan sehingga masih banyak menggunakan pupuk maupun pestisida buatan dalam upaya peningkatan produksinya, tanpa menyadari membahayakan lingkungan. Untuk mengatasi kesenjangan pengetahuan dan pemahaman, dan peningkatan ketrampilan masyarakat Tim Pengabdian Masyarakat SITH ITB berusaha memberikan pemahaman tentang pentingnya pertanian berkelanjutan dan pelatihan identifikasi organisme pengganggu tanaman (OPT) dan produksi biopestisida dari tanaman disekitar, sehingga mereka bisa mendukung program pertanian berkelanjutan. Program ini sangat penting untuk meningkatkan kualitas hidup para petani dengan edukasi dan pelatihan ketrampilan yang akan membawa perbaikan produksi tanaman dan lingkungan hidup. Hasil Kegiatan menunjukkan adanya program pengabdian masyarakat ini mampu menambah pengetahuan dan pemahaman tentang pertanian berkelanjutan, ketrampilah identifikasi organisme pengganggu tanaman, dan produksi biopestisida dari sumber daya mikroba dan tanaman sekitar.
Unraveling the corrosion inhibition behavior of prinivil drug on mild steel in 1M HCl corrosive solution: insights from density functional theory, molecular dynamics, and experimental approaches
Authors: Thakur Abhinay , Kumar Ashish , Dagdag Omar , Kim Hansang , Berisha Avni , Sharma Deepak , Om Hari 
Published: June 2024

The deterioration of mild steel in an acidic environment poses a significant challenge in various industries. The emergence of effective corrosion inhibitors has drawn attention to studies aimed at reducing the harmful consequences of corrosion. In this study, the corrosion inhibition efficiency of Prinivil in a 1M HCl solution through various electrochemical and gravimetric techniques has been investigated for the first time. The results demonstrated that the inhibition efficiency of Prinivil expanded from 61.37% at 50 ppm to 97.35% at 500 ppm concentration at 298 K. With a regression coefficient (R2) of 0.987, Kads value of 0.935 and Ea value of 43.024 kJ/mol at 500 ppm concentration of inhibitor, a strong affinity of Prinivil for adsorption onto the metal surface has been significantly found. Scanning electron microscopy (SEM) and contact angle measurement analyses further support the inhibitory behavior of Prinivil, demonstrating the production of a defensive layer on the surface of mild steel. Additionally, molecular dynamics (MD) and Monte Carlo simulations were employed to investigate the stability and interactions between Prinivil and the metallic surface (Fe (1 1 0)) at the atomic level. The computed results reveal strong adsorption of Prinivil upon the steel surface, confirming its viability as a corrosion inhibitor.
Association between systemic immunity-inflammation index and sex hormones in children and adolescents aged 6–19
Authors: Gao Zijun , Liu Ke 
Published: June 2024

ObjectivesThis study aimed to evaluate the relationship between systemic immune-inflammation index (SII) and sex hormones in children and adolescents aged 6–19 years.MethodsData were obtained from the National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Inclusion criteria comprised subjects aged 6–19 years with complete data on both SII and sex hormones. We employed weighted multiple regression analysis and subgroup analytical methods to independently estimate the relationship between SII and sex hormones.ResultsIn this study, a total of 3767 participants were included, with an average age of 12.32 ± 3.95 years. Males constituted 50.54%, and females 49.46%. Among males, a statistically significant negative correlation emerged between SII and sex hormone-binding globulin (SHBG). Similarly, in the female population, SII exhibited a statistically significant negative correlation with total testosterone (TT), SHBG, and the Ratio of TT to estradiol, while maintaining a positive correlation with free androgen index (FAI). Subgroup analysis underscored variances in the association between sex hormones and SII within cohorts distinguished by pubertal status or different body mass index (BMI). In addition, the relationship between SII and estradiol exhibited nonlinearity. Employing a two-segment linear regression model, we identified an inverted U-shaped association between SII and estradiol, with an inflection point of 748.09 (1000cell/ml).ConclusionOur findings suggest that SII may be an independent risk factor for changes in sex hormones in both male and female children and adolescents. More prospective and experimental studies should be conducted to validate our results and elucidate the underlying molecular pathways.
The human milk endocannabinoidome and neonatal growth in gestational diabetes
Authors: Fradet Alice , Castonguay-Paradis Sophie , Dugas Camille , Perron Julie , St-Arnaud Gabrielle , Marc Isabelle , Doyen Alain , Flamand Nicolas , Dahhani Fadil , Di Marzo Vincenzo , Veilleux Alain , Robitaille Julie 
Published: June 2024

ObjectiveEndocannabinoids and their N-acyl-ethanolamines (NAEs) and 2monoacyl-glycerols (2-MAGs) congeners are involved in the central and peripheral regulation of energy homeostasis, they are present in human milk and are associated with obesity. Infants exposed in utero to gestational diabetes mellitus (GDM) are more likely to develop obesity. The objective of this cross-sectional study is to compare the profile of eCBome mediators in milk of women with gestational diabetes (GDM+) and without (GDM-) and to assess the association with offspring growth. The hypothesis is that the eCBome of GDM+ human milk is altered and associated with a difference in infant growth.MethodsCirculating eCBome mediators were measured by LC-MS/MS in human milk obtained at 2 months postpartum from GDM+ (n=24) and GDM- (n=29) women. Infant weight and height at 2 months were obtained from the child health record. Z-scores were calculated.ResultsCirculating Npalmitoylethanolamine (PEA) was higher in human milk of GDM+ women than in GDM- women (4.9 ± 3.2 vs. 3.3 ± 1.7, p=0.04). Higher levels were also found for several 2monoacyl-glycerols (2-MAGs) (p&lt;0.05). The levels of NAEs (β=-4.6, p=0.04) and especially non-omega-3 NAEs (B=-5.6, p=0.004) in human milk were negatively correlated with weight-for-age z-score of GDM+ offspring.ConclusionThe profile of eCBome mediators in human milk at 2 months postpartum was different in GDM+ compared to GDM- women and was associated with GDM+ offspring growth at 2 months.Clinical trial registrationClinicalTrials.gov, identifier (NCT04263675 and NCT02872402).
Tidal effect on environmental DNA communities in Arctic estuarine and marine ecosystems
Authors: Sevellec Maelle , Lacoursière-Roussel Anaïs , Normandeau Eric , Bernatchez Louis , Howland Kimberly 
Published: June 2024

IntroductionArctic marine ecosystems are changing rapidly, largely due to the observed accelerated warming that is associated with ongoing climate change. Environmental DNA (eDNA) combined with metabarcoding has great potential for large-scale biomonitoring of Arctic marine communities. However, important limitations remain, such as understanding the complexity and drivers of spatio-temporal variation in eDNA distribution.MethodsIn this study, we investigated the effect of tidal dynamics on aquatic metazoan (vertebrates and invertebrates) on eDNA metabarcoding results from nearshore estuarine and marine Arctic ports of Churchill (Manitoba) and Milne Inlet (Nunavut), respectively. We collected and sequenced 54 water samples per port at low, middle and high tide across three days, as well as two depths (surface, bottom), using four universal primer pairs (two primers in the COI gene and two in the 18S rRNA gene).ResultsWe observed a significant transition in the estuarine community structure from low to high tide, whereas the marine community structure was more stable across tides. The eDNA community structure differed between the surface and bottom waters in both the estuarine and marine ecosystems. However, the biodiversity pattern within the water column was significantly different between estuarine and marine ecosystems. Finally, we observed short-term temporal variation of the communities in both systems.DiscussionAltogether, our results highlight the short-term temporal dynamic nature of eDNA derived from coastal communities. This variability should be accounted for in eDNA sampling design to ensure robust characterization of coastal communities and long-term time series, particularly for estuarine environments where the effects of tide and depth are more important.
QUALIPAED—A retrospective quality control study evaluating pediatric long axial field-of-view low-dose FDG-PET/CT
Authors: Honoré d’Este Sabrina , Andersen Flemming Littrup , Schulze Christina , Saxtoft Eunice , Fischer Barbara Malene , Andersen Kim Francis 
Published: June 2024

IntroductionPediatric patients have an increased risk of radiation-induced malignancies due to their ongoing development and long remaining life span. Thus, optimization of PET protocols is an important task in pediatric nuclear medicine. Long axial field-of-view (LAFOV) PET/CT has shown a significant increase in sensitivity, which provides an ideal opportunity for reduction of injected tracer activity in the pediatric population. In this study we aim to evaluate the clinical performance of a 2-[18F]FDG-tracer reduction from 3 MBq/kg to 1.5 MBq/kg on the Biograph Vision Quadra LAFOV PET/CT.Materials and methodsThe first 50 pediatric patients referred for clinical whole-body PET/CT with 1.5 MBq/kg 2-[18F]FDG, were included. A standard pediatric protocol was applied. Five reconstructions were created with various time, filter and iteration settings. Image noise was computed as coefficient-of-variance (COV = SD/mean standardized-uptake-value) calculated from a spherical 20–50 mm (diameter) liver volume-of-interest. Sets of reconstructions were reviewed by one nuclear medicine physicians, who reported image lesions on a pre-defined list of sites. Paired comparison analysis was performed with significance at PB &lt; 0.05 (Bonferroni corrected).ResultsAll reconstructions, except one, achieved a COVmean (0.08–0.15) equal to or lower than current clinical acceptable values (COVref ≤ 0.15). Image noise significantly improved with increasing acquisition time, lowering iterations (i) from 6i to 4i (both with five subsets) and when applying a 2 mm Gauss filter (PB &lt; 0.001). Significant difference in lesion detection was seen from 150s to 300s and from 150s to 600s (PB = 0.006–0.007). 99% of all lesions rated as malignant could be found on the 150s reconstruction, while 100% was found on the 300s, when compared to the 600s reconstruction.ConclusionInjected activity and scan time can be reduced to 1.5 MBq/kg 2-[18F]FDG with 5 min acquisition time on LAFOV PET/CT, while maintaining clinical performance in the pediatric population. These results can help limit radiation exposure to patients and personnel as well as shorten total scan time, which can help increase patient comfort, lessen the need for sedation and provide individually tailored scans.
A pilot study on the characterization and correlation of oropharyngeal and intestinal microbiota in children with type 1 diabetes mellitus
Authors: Wang Limin , Gong Chao , Wang Ruiye , Wang Jinxue , Yang Zhanshuang , Wang Xianhe 
Published: June 2024

BackgroundType 1 Diabetes Mellitus (T1DM) is one of the most common endocrine disorders of childhood and adolescence, showing a rapidly increasing prevalence worldwide. A study indicated that the composition of the oropharyngeal and gut microbiota changed in T1DM. However, no studies have yet associated the changes between the microbiomes of the oropharyngeal and intestinal sites, nor between the flora and clinical indicators. In this study, we examined the composition and characteristics of oropharyngeal and intestinal flora in patients with T1DM in compared to healthy children. We identified correlations between oropharyngeal and intestinal flora and evaluated their association with clinical laboratory tests in patients with T1DM.MethodsThe oropharyngeal and fecal samples from 13 T1DM and 20 healthy children were analyzed by high-throughput sequencing of the V3–V4 region of 16S rRNA. The associations between microbes and microorganisms in oropharyngeal and fecal ecological niches, as well as the correlation between these and clinical indicators were further analyzed.ResultsIt was revealed that T1DM children had distinct microbiological characteristics, and the dominant oropharyngeal microbiota genus included Streptococcus, Prevotella, Leptotrichia, and Neisseria; that of intestinal microbiota included Blautia, Fusicatenibacter, Bacteroides, and Eubacterium_hallii_group. Furthermore, oropharyngeal Staphylococcus was significantly positively correlated with intestinal norank_f__Ruminococcaceae and Ruminococcus_torques_group in TIDM children. Moreover, in these children, differential genes in oropharyngeal and intestinal samples were enriched in metabolic pathways such as amino acid generation, fatty acid metabolism, and nucleotide sugar biosynthesis. Additionally, correlation analysis between the oropharyngeal/intestinal microbiome with laboratory tests showed significant correlations between several bacterial taxa in the oropharynx and intestines and glycated hemoglobin and C-peptide.ConclusionUnique microbial characteristics were found in the oropharynx and intestine in children with T1DM compared to healthy children. Positive correlations were found between changes in the relative abundance of oropharyngeal and gut microbiota in children with T1DM. Associations between the oropharyngeal/intestinal microbiota and laboratory investigations in children with T1DM suggest that the composition of the oropharyngeal and intestinal flora in children with T1DM may have some impact on glycemic control.
Efficacy and safety of Osteoking on fracture healing: a systematic review and meta-analysis
Authors: Zhang Le , Kuang Haomin , Zhang Zimin , Rong Kuan , Yuan Yiwei , Peng Zhifei , Zhao Haomin , Liu Ke , Ou Liang , Kuang Jianjun 
Published: June 2024

BackgroundOsteoking (OK) is prescribed in traditional Chinese medicine to accelerate fracture healing. Although some studies suggest the potential efficacy of OK for fracture healing, the evidence remains inconclusive.AimTo systematically evaluate the safety of OK and its effect on fracture healing.MethodsRelevant authoritative databases were searched until 25 August 2023. Randomized controlled trials (RCTs) of patients with fractures treated with Osteoking were included. We evaluated the risk of bias using the Cochrane tool and performed a meta-analysis using the Review Manager 5.4 software package.Results13 studies involving 1123 participants were included. This meta-analysis showed that compared with observations in the control group, the OK group showed a shortened fracture healing time, increased fracture healing rate, reduced swelling regression time and ecchymosis regression time, and improved bone metabolism. In addition, the included studies did not report any serious side effects associated with the use of OK, and the mild side effects resolved without treatment.ConclusionOK therapy is beneficial and safe for accelerating fracture healing, reducing swelling, eliminating ecchymosis, and improving bone metabolism. However, the meta-analysis results do not support OK treatment for improving the fracture healing rate at all fracture sites and reducing pain across all fracture sites. Further original, high-quality studies are needed to validate these findings.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=452430, identifier CRD42023452430.
A systematic review of the impact of type 2 diabetes on brain cortical thickness
Authors: Motaghi Mahboubeh , Potvin Olivier , Duchesne Simon 
Published: June 2024

IntroductionType 2 diabetes (T2D) has been linked to cognitive impairment and dementia, but its impact on brain cortical structures in individuals prior to or without cognitive impairment remains unclear.MethodsWe conducted a systematic review of 2,331 entries investigating cerebral cortical thickness changes in T2D individuals without cognitive impairment, 55 of which met our inclusion criteria.ResultsMost studies (45/55) reported cortical brain atrophy and reduced thickness in the anterior cingulate, temporal, and frontal lobes between T2D and otherwise cognitively healthy controls. However, the balance of studies (10/55) reported no significant differences in either cortical or total brain volumes. A few reports also noticed changes in the occipital cortex and its gyri. As part of the reports, less than half of studies (18/55) described a correlation between T2D and hippocampal atrophy. Variability in sample characteristics, imaging methods, and software could affect findings on T2D and cortical atrophy.DiscussionIn conclusion, T2D appears linked to reduced cortical thickness, possibly impacting cognition and dementia risk. Microvascular disease and inflammation in T2D may also contribute to this risk. Further research is needed to understand the underlying mechanisms and brain health implications.