bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Intramolecular 1,4‐Addition of Nitrogen Nucleophile and Bromine Electrophile to Conjugated 1,3‐Enyne.
Authors: Liu Na , Werness Jenny B. , Guzei Ilia A. , Tang Weiping 
Published: September 2011

AbstractIt is discovered, that 1,4‐halocyclization of conjugate enynes (I) and (VII) is intrinsically favored over 1,2‐addition.
ChemInform Abstract: New Experimental Conditions for Tandem Hydroalumination/Cu‐Catalyzed Asymmetric Conjugate Additions to β‐Substituted Cyclic Enones.
Authors: Mueller Daniel , Tissot Matthieu , Alexakis Alexandre 
Published: September 2011

AbstractA variety of alkenylalanes is applied in cyclopentenone, cyclohexenone and cycloheptenone derivatives using SimplePhos monodentate ligands.
ChemInform Abstract: Sulfoxide—Alkene Hybrids: A New Class of Chiral Ligands for the Hayashi—Miyaura Reaction.
Authors: Thaler Tobias , Guo Li‐Na , Steib Andreas K. , Raducan Mihai , Karaghiosoff Konstantin , Mayer Peter , Knochel Paul 
Published: September 2011

AbstractNovel ligands of type (I)‐(III) can be applied for in situ preparation of catalyst systems which promote the title reactions.
ChemInform Abstract: Microwave‐Accelerated Ruthenium‐Catalyzed [2π + 2π] Cycloadditions of Dimethylacetylene Dicarboxylate with Norbornenes.
Authors: Margetic Davor , Troselj Pavle , Murata Yasujiro 
Published: September 2011

AbstractThis is the first account of a microwave‐assisted Mitsudo reaction.
ChemInform Abstract: Copper‐Catalyzed Aromatic Trifluoromethylation via Group Transfer from Fluoral Derivatives.
Authors: Kondo Hideaki , Oishi Masahiro , Fujikawa Kenichi , Amii Hideki 
Published: September 2011

AbstractA new and efficient method to prepare a wide range of trifluoromethylated arenes is reported.
ChemInform Abstract: Mechanistic and Computational Studies of Oxidatively‐Induced Aryl—CF3 Bond‐Formation at Pd: Rational Design of Room Temperature Aryl Trifluoromethylation.
Authors: Ball Nicholas D. , Gary J. Brannon , Ye Yingda , Sanford Melanie S. 
Published: September 2011

AbstractThe mechanism of the oxidatively‐induced trifluoromethylation of arenes at Pd is studied.
ChemInform Abstract: Direct Aldol Reactions Catalyzed by a Heterogeneous Guanidinium Salt/Proline System under Solvent‐Free Conditions.
Authors: Martinez‐Castaneda Angel , Poladura Belen , Rodriguez‐Solla Humberto , Concellon Carmen , del Amo Vicente 
Published: September 2011

AbstractThe reaction of various aromatic aldehydes with cyclic ketones or acetone is effectively catalyzed by the title system.
ChemInform Abstract: Rhodium‐Catalyzed Branched‐Selective Alkyne Hydroacylation: A Ligand‐Controlled Regioselectivity Switch.
Authors: Gonzalez‐Rodriguez Carlos , Pawley Rebekah J. , Chaplin Adrian B. , Thompson Amber L. , Weller Andrew S. , Willis Michael C. 
Published: September 2011

AbstractThe regioselectivity can be controlled by the diphosphine ligand used.
ChemInform Abstract: Diastereoselective Three‐Component Reactions of Aryldiazoacetates with Alcohols/Water and Alkynals: Application to Substituted Enelactones.
Authors: Han Xingchun , Jiang Liqing , Tang Min , Hu Wenhao 
Published: September 2011

AbstractThe method results in efficient and stereoselective formation of hydroxycarboxylic acid esters such as (IV), (VII), and (VIII).
ChemInform Abstract: Synthesis of Poly‐Nitrile Aromatics via Palladium‐Catalyzed Cyanation of Aryl Bromides with Potassium Hexacyanoferrate(II).
Authors: Becker Martin , Schulz Axel , Voss Karsten 
Published: September 2011

AbstractPolynitrile aromatics are obtained from easily available aryl bromides in a modified Beller′s palladium‐catalyzed cyanation procedure.
ChemInform Abstract: Highly Regio‐ and Stereoselective Hydrothiolation of Acetylenes with Thiols Catalyzed by a Well‐Defined Supported Rh Complex.
Authors: Yang Yong , Rioux Robert M. 
Published: September 2011

AbstractA rhodium‐catalyzed hydrothiolation of alkynes (I) and (IV) furnishing (E)‐anti‐Markovnikov adducts (III) and (V) as main or sole reaction products is given.
ChemInform Abstract: Rhodium‐Catalyzed Selective C—H Activation/Olefination of Phenol Carbamates.
Authors: Gong Tian‐Jun , Xiao Bin , Liu Zhao‐Jing , Wang Jian , Xu Jun , Luo Dong‐Fen , Fu Yao , Liu Lei 
Published: September 2011

AbstractThe ortho‐C—H activation/olefination method is complementary to the Pd‐catalyzed process for the ortho‐arylation of esters and carbamates.
ChemInform Abstract: A Cascade Process for the Synthesis of gem‐Difluoromethylene Compounds.
Authors: Chen Zixian , Zhu Jiangtao , Xie Haibo , Li Shan , Wu Yongming , Gong Yuefa 
Published: September 2011

AbstractTreatment of fluoroalkylated β‐enaminoarylketones with K2CO3 or K3PO4 allows efficient access to 2,2‐difluorodihydrofurans.
ChemInform Abstract: Chiral Rh‐ and Ir‐Catalyzed Intramolecular Cycloaddition of Hexaynes for the Construction of New Chiral Skeletons.
Authors: Shibata Takanori , Chiba Tatsuya , Hirashima Hiroyuki , Ueno Yasunori , Endo Kohei 
Published: September 2011

AbstractThe chiral Rh complex catalyzes the consecutive [2+2+2] cycloadditions, whereas the chiral neutral Ir complex causes a single [2 + 2 + 2] cycloaddition.
ChemInform Abstract: Novel (E)‐5‐Styryl‐2,2′‐bithiophene Derivatives as Ligands for β‐Amyloid Plaques.
Authors: Cui Mengchao , Li Zijing , Tang Ruikun , Jia Hongmei , Liu Boli 
Published: September 2011

AbstractWittig reaction of bithiophenecarbaldehydes (I) with triphenyl phosphonium ylides (II) yields the target styrylbithiophene derivatives (III).
ChemInform Abstract: Facile Creation of 2‐Substituted Indolin‐3‐ones by Using Primary—Secondary Diamine Catalysts.
Authors: Sun Wangsheng , Hong Liang , Wang Rui 
Published: September 2011

AbstractThe asymmetric organocatalytic conjugate addition of acetylindolinone to enones constitutes an easy and efficient method for the direct preparation of substituted indolinones.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Trifluoromethylation of Indoles at Room Temperature.
Authors: Mu Xin , Chen Shujun , Zhen Xingliang , Liu Guosheng 
Published: September 2011

AbstractThis novel palladium‐catalyzed oxidation strategy is applicable to a wide range of substituted indoles including different substituents on the nitrogen.
ChemInform Abstract: New Carbazole‐Containing Chalcones and Pyrimidines Based Thereon: Synthesis and Electrochemical Study.
Authors: Syutkin R. V. , Abashev G. G. , Shklyaeva E. V. , Kudryavtsev P. G. 
Published: September 2011

AbstractA variety of new carbazole‐containing chalcones such as (VII), (XI) and (XII) are synthesized via condensations of aldehydes (V) or (X) with methyl ketones (VI) or (IX), respectively.
ChemInform Abstract: An Efficient Synthesis of Imidazolinium Salts Using Vinyl Sulfonium Salts.
Authors: McGarrigle Eoghan M. , Fritz Sven P. , Favereau Ludovic , Yar Muhammad , Aggarwal Varinder K. 
Published: September 2011

AbstractSymmetrical and unsymmetrical title compounds are prepared with tolerance of functional and sterically hindered groups.
ChemInform Abstract: C—H Bond Arylations and Benzylations on Oxazol(in)es with a Palladium Catalyst of a Secondary Phosphine Oxide.
Authors: Ackermann Lutz , Barfuesser Sebastian , Kornhaass Christoph , Kapdi Anant R. 
Published: September 2011

AbstractThe sterically congested palladium catalyst (I) allows a direct arylation of the oxazole (I) and oxazolines (VIII) and the benzylation of (I) and benzoxazole (XI) according to the conditions A), B) or C).
ChemInform Abstract: 1,3‐Dipolar Cycloadditions. Part 21. Catalytic Effects of Lewis Acids on 1,3‐Dipolar Cycloaddition of C‐(4‐Chlorophenyl)‐N‐phenyl Nitrone to Benzylidene Acetophenone.
Authors: Acharjee Nivedita , Banerji Avijit , Prange Thierry 
Published: September 2011

AbstractThe catalytic effects of Lewis acids on the 1,3‐dipolar cycloaddition of nitrone (I) to benzylidene acetophenone (II) is studied.
ChemInform Abstract: Synthesis of Spirocyclic Thiazolidinediones Using Ring‐Closing Metathesis and One‐Pot Sequential Ring‐Closing/Cross Metathesis.
Authors: Dhara Kalyan , Paladhi Sushovan , Midya Ganesh Chandra , Dash Jyotirmayee 
Published: September 2011

AbstractIt allows a new access to 1‐thia‐3‐azaspiro[4.4]nonene and [4.5]decene ring systems.
ChemInform Abstract: Design, Synthesis and Evaluation of Novel Rhodanine‐Containing Sorafenib Analogues as Potential Antitumor Agents.
Authors: Li Wei , Zhai Xin , Zhong Zheng , Li Guangyue , Pu Yongxiao , Gong Ping 
Published: September 2011

AbstractA variety of new sorafenib analogues (XII) (29 examples) are synthesized and evaluated for their in vitro antitumor activity.
ChemInform Abstract: Synthesis of 2,3‐Dihydro‐4(1H)‐quinolones and the Corresponding 4(1H)‐Quinolones via Low‐Temperature Fries Rearrangement of N‐Arylazetidin‐2‐ones.
Authors: Lange Jens , Bissember Alex C. , Banwell Martin G. , Cade Ian A. 
Published: September 2011

AbstractCompounds (I) and (IV) are synthesized by Goldberg—Buchwald cross‐coupling and compounds (VII) by intramolecular Mitsunobu cyclization.
ChemInform Abstract: A Green Expedient Synthesis of Pyridopyrimidine‐2‐thiones and Their Antitubercular Activity.
Authors: Rajesh Stephen Michael , Kumar Raju Suresh , Libertsen Lawzer Arun , Perumal Subbu , Yogeeswari Perumal , Sriram Dharmarajan 
Published: September 2011

AbstractThe pseudo four‐component domino reactions of N‐substituted‐4‐piperidones, substituted aromatic aldehydes and thiourea in the presence of solid sodium ethoxide under solvent‐free conditions affords pyridopyrimidine‐2‐thiones (IV) in almost quantitative yields by simply grinding.
ChemInform Abstract: An Efficient Approach to Azirino and Pyrrolo‐Fused Dibenzazepines. Conformations of Substituted Dibenzo[c,f]pyrrolo[1,2‐a]azepines.
Authors: Khlebnikov Alexander F. , Novikov Mikhail S. , Golovkina Maria V. , Petrovskii Petr P. , Konev Alexander S. , Yufit Dmitry S. , Stoeckli‐Evans Helen 
Published: September 2011

AbstractThe dibenzopyrroloazepines can exist in two different conformations depending on the nature of substituents.
ChemInform Abstract: Preparation of 5‐Membered Rings via Radical Addition‐Translocation‐Cyclization (RATC) Processes Mediated by Diethyl Thiophosphites.
Authors: Lamarque Christophe , Beaufils Florent , Denes Fabrice , Schenk Kurt , Renaud Philippe 
Published: September 2011

AbstractMonocyclic, bicyclic, and spirocyclic 5‐membered ring products are available.
ChemInform Abstract: Free Radical Addition of α‐Telluroesters to Alkenes.
Authors: Kambe Nobuaki , Han Li‐Biao , Fujiwara Shin‐ichi , Sonoda Noboru 
Published: September 2011

AbstractThe title reaction leads to the compounds (III), (VI), (VIII), and (X) and suppresses the competing olefin polymerization.
ChemInform Abstract: Regioselective Benzoylation of Glycopyranosides by Benzoyl Chloride in the Presence of MoO2(acac)2.
Authors: Evtushenko E. V. 
Published: September 2011

AbstractThe MoO2(acac)2‐catalyzed regioselective benzoylation of glycopyranosides leads to a variety of 3‐benzoylpyranosides, e.g. compounds (III) and (V).
ChemInform Abstract: New Methodology for the Differentiation of the Primary Hydroxyl Groups in 2,3,3′,4,4′‐Penta‐O‐benzylsucrose: Convenient Approach to Sucrose Monophosphines.
Authors: Burdynska Joanna , Lewandowski Bartosz , Jarosz Slawomir 
Published: September 2011

AbstractThe reaction of penta‐O‐benzyl sucrose (I) with tert‐butyldiphenylsilyl chloride proceeds regioselectively to afford 6′‐O‐silyl derivative (III), which is used for the synthesis of iodide (VI).
ChemInform Abstract: Ready Access to 3‐Amino‐2,3‐dideoxysugars via Regio‐ and Stereo‐Selective Tandem Hydroamination—Glycosylation of Glycals.
Authors: Ding Feiqing , William Ronny , Wang Siming , Gorityala Bala Kishan , Liu Xue‐Wei 
Published: September 2011

AbstractA simple, efficient, and highly stereoselective method to prepare a wide range of biologically interesting 3‐amino‐2,3‐dideoxysugars is reported.
Biotemplated Materials for Sustainable Energy and Environment: Current Status and Challenges
Authors: Zhou Han , Fan Tongxiang , Zhang Di 
Published: September 2011

AbstractMaterials science will play a key role in the further development of emerging solutions for the increasing problems of energy and environment. Materials found in nature have many inspiring structures, such as hierarchical organizations, periodic architectures, or nanostructures, that endow them with amazing functions, such as energy harvesting and conversion, antireflection, structural coloration, superhydrophobicity, and biological self‐assembly. Biotemplating is an effective strategy to obtain morphology‐controllable materials with structural specificity, complexity, and related unique functions. Herein, we highlight the synthesis and application of biotemplated materials for six key areas of energy and environment technologies, namely, photocatalytic hydrogen evolution, CO2 reduction, solar cells, lithium‐ion batteries, photocatalytic degradation, and gas/vapor sensing. Although the applications differ from each other, a common fundamental challenge is to realize optimum structures for improved performances. We highlight the role of four typical structures derived from biological systems exploited to optimize properties: hierarchical (porous) structures, periodic (porous) structures, hollow structures, and nanostructures. We also provide examples of using biogenic elements (e.g., C, Si, N, I, P, S) for the creation of active materials. Finally, we disscuss the challenges of achieving the desired performance for large‐scale commercial applications and provide some useful prototypes from nature for the biomimetic design of new materials or systems. The emphasis is mainly focused on the structural effects and compositional utilization of biotemplated materials.
In vivo multispectral photoacoustic and photothermal flow cytometry with multicolor dyes: A potential for real‐time assessment of circulation, dye‐cell interaction, and blood volume
Authors: Proskurnin Mikhail A. , Zhidkova Tatyana V. , Volkov Dmitry S. , Sarimollaoglu Mustafa , Galanzha Ekaterina I. , Mock Donald , Nedosekin Dmitry A. , Zharov Vladimir P. 
Published: September 2011

AbstractRecently, photoacoustic (PA) flow cytometry (PAFC) has been developed for in vivo detection of circulating tumor cells and bacteria targeted by nanoparticles. Here, we propose multispectral PAFC with multiple dyes having distinctive absorption spectra as multicolor PA contrast agents. As a first step of our proof‐of‐concept, we characterized high‐speed PAFC capability to monitor the clearance of three dyes (Indocyanine Green [ICG], Methylene Blue [MB], and Trypan Blue [TB]) in an animal model in vivo and in real time. We observed strong dynamic PA signal fluctuations, which can be associated with interactions of dyes with circulating blood cells and plasma proteins. PAFC demonstrated enumeration of circulating red and white blood cells labeled with ICG and MB, respectively, and detection of rare dead cells uptaking TB directly in bloodstream. The possibility for accurate measurements of various dye concentrations including Crystal Violet and Brilliant Green were verified in vitro using complementary to PAFC photothermal (PT) technique and spectrophotometry under batch and flow conditions. We further analyze the potential of integrated PAFC/PT spectroscopy with multiple dyes for rapid and accurate measurements of circulating blood volume without a priori information on hemoglobin content, which is impossible with existing optical techniques. This is important in many medical conditions including surgery and trauma with extensive blood loss, rapid fluid administration, and transfusion of red blood cells. The potential for developing a robust clinical PAFC prototype that is safe for human, and its applications for studying the liver function are further highlighted. © 2011 International Society for Advancement of Cytometry.
P‐glycoprotein activity in human Caucasian male lymphocytes does not follow its increased expression during aging
Authors: Vilas‐Boas Vânia , Silva Renata , Gaio A. Rita , Martins Ana Margarida , Lima Sofia Costa , Cordeiro‐da‐Silva Anabela , de Lourdes Bastos Maria , Remião Fernando 
Published: September 2011

AbstractP‐glycoprotein (P‐gp) is a transmembrane protein that mediates the efflux of innumerous structurally unrelated compounds. It was initially found over‐expressed in tumor cells, associated to a multidrug resistance phenotype (MDR). Then, P‐gp was found constitutively expressed in excretory cells/tissues and in circulating cells, such as lymphocytes. Considering the importance of this transporter in the establishment of therapeutic protocols and the existence of contradictory results, this study aimed at evaluating the influence of aging in the expression and function of P‐gp in human lymphocytes, comparing two different methodologies to assess both parameters. P‐gp activity and expression were evaluated in lymphocytes isolated from whole blood samples of 65 healthy caucasian male donors, divided into two groups according to age (group 1: under 30‐years old; group 2: above 60‐years old). P‐gp expression was assessed using the anti‐P‐gp monoclonal antibody, UIC2, in the presence and in absence of vinblastine (Vbl). P‐gp activity was evaluated measuring the efflux rate of the fluorescent P‐gp substrate rhodamine 123 (Rho 123) and also using UIC2 shift assay. Flow cytometric analysis was performed to assess all the proceedings. Furthermore, P‐gp expression and each of the P‐gp activity determination methods were compared, through correlation analysis and linear regression models. We observed a significant age‐dependent increase in mean P‐gp expression (p = 0.029), which was not reflected in the transporter's activity (p > 0.050). Statistical analysis allowed selection of UIC2 shift assay over Rho 123 efflux assay as a more selective method to assess P‐gp activity. Despite the significant correlation between P‐gp expression and P‐gp activity found in lymphocytes (Gp1(group 1)—r = 0.609, p < 0.001; Gp2—r = 0.461, p = 0.012), using UIC2 shift assay, these data reinforce the need for P‐gp activity assessment, rather than P‐gp expression determination alone, when starting new therapeutic regimens with P‐gp substrates, especially in men older than 60 years of age. © 2011 International Society for Advancement of Cytometry
Development of high‐throughput methods to quantify cysts of Toxoplasma gondii
Authors: Aldebert D. , Hypolite M. , Cavailles P. , Touquet B. , Flori P. , Loeuillet C. , Cesbron‐Delauw M. F. 
Published: September 2011

AbstractToxplasma is a protozoan parasite, which forms persistent cysts in tissues of chronically infected animals and humans. Cysts can reactivate leading to severe pathologies. They also contribute to the transmission of Toxoplasma infection in humans by ingestion of undercooked meat. Classically, the quantification of cyst burden in tissues uses microscopy methods, which are laborious and time consuming. Here, we have developed automated protocols to quantify cysts, based on flow cytometry or high‐throughput microscopy. Brains of rodents infected with cysts of Prugniaud strain were incubated with the FITC‐Dolichos biflorus lectin and analyzed by flow cytometry and high‐throughput epifluorescence microscopy. The comparison of cyst counts by manual epifluorescence microscopy to flow cytometry or to high‐throughput epifluorescence microscopy revealed a good correlation (r = 0.934, r = 0.993, P < 0.001 respectively). High‐throughput epifluorescence microscopy was found to be more specific and sensitive than flow cytometry and easier to use for large series of samples. This reliable and easy protocol allow the specific detection of Toxoplasma cysts in brain, even at low concentrations; it could be a new way to detect them in water and in contaminate food. © 2011 International Society for Advancement of Cytometry
Recent advances in dynamic intravital multi‐photon microscopy
Authors: Niesner Raluca A. , Hauser Anja E. 
Published: September 2011

AbstractStandard multiphoton laser scanning microscopy (MPLSM) has revolutionized our view of physiologic and pathologic processes in living organisms by enlightening different aspects of cellular choreography in immune responses, that is, cellular motility and co‐localization. To understand cellular communication on a molecular level, novel transgenic reporter mice have been generated. In parallel, MPLSM systems have been developed, which make it possible for this technique to be more widely used to address crucial immunological questions. Here, we review the latest progress concerning transgenic mouse technology and multiphoton imaging capacities and discuss further developments which will enable us to visualize all around monitoring and quantification of cellular function at a molecular level directly in vivo. © 2011 International Society for Advancement of Cytometry
Efficient use of DS/CDMA signals for broadband communications over power lines
Authors: Al‐Bayati A.K.S. , Aloquili O.M. , Al Nabulsi J.I. 
Published: September 2011

SUMMARYThis paper investigates the use of direct‐sequence/code‐division multiple access (DS/CDMA) signals for broadband communications over power lines. Each user is assumed to utilize all available spreading codes for sending the information to the destination. The transmitter and the receiver are assumed to have perfect channel knowledge with the receiver employing a zero‐forcing multiuser detector. Based on channel knowledge we attempt to maximize the data throughput by suitable choice of the number of codes used and the power and the constellation size (bit‐load) assigned to the data modulating each spreading code. We employ Gold codes, in addition to special codes derived based on the channel knowledge for ISI minimization, termed ‘eigen codes’. In contrast to some earlier results concerning CDMA and OFDM, we show that DS/CDMA signals can be optimized to achieve an overall data throughput of approximately 80% of that achieved by OFDM systems. This result shows that DS/CDMA signaling can be a good candidate for broadband power line communications. Copyright © 2011 John Wiley & Sons, Ltd.
Commentary on ‘Combined oral contraceptive pills for treatment of acne’
Authors: Tan Jerry K.L. , Danby F. William 
Published: September 2011

AbstractThis is a commentary of a Cochrane review, published in this issue of EBCH, first published as: Ayodele O. Arowojolu, Maria F. Gallo, Laureen M. Lopez, David A. Grimes, and Sarah E. Garner. Combined oral contraceptive pills for treatment of acne. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD004425. DOI: 10.1002/14651858.CD004425.pub4.acne.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration