bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Anticonvulsant and Toxicity Evaluation of Newer 4H‐Benzo[1,4]oxazin‐3‐ones: The Effect of Two Hydrogen Bonding Domains.
Authors: Siddiqui Nadeem , Ali Ruhi , Arshad M. Faiz , Ahsan Waquar , Ahmed Sharique , Alam M. Shamsher 
Published: March 2011

Abstract18 Compounds of type (I) are prepared and tested for their anticonvulsant activities.
ChemInform Abstract: Synthesis of Purine Derivatives as Scaffolds for a Diversity of Biological Activities
Authors: Conejo‐Garcia A. , Cruz‐Lopez O. , Gomez‐Perez V. , Morales F. , Garcia‐Rubino M. E. , Kimatrai M. , Nunez M. C. , Campos J. M. 
Published: March 2011

AbstractReview: 128 refs.
CD38 identifies a hypo‐proliferative IL‐13‐secreting CD4+ T‐cell subset that does not fit into existing naive and memory phenotype paradigms
Authors: Scalzo‐Inguanti Karen , Plebanski Magdalena 
Published: March 2011

AbstractCD38 is commonly regarded as an activation marker for human T cells. Herein, we show that CD38 expression identifies a hypo‐proliferative CD4+ T‐cell subset that, following TCR stimulation, retains expression of naive cell surface markers including CD45RA, CD62L and CCR7. Hypo‐proliferation was mediated by reduced CD25 up‐regulation upon TCR stimulation compared to CD4+CD38− cells and lack of responsiveness to exogenous IL‐2. Instead, CD4+CD38+ T cells expressed CD127, and hypo‐proliferation was reversed by addition of IL‐7, further associated with increased STAT5 phosphorylation. This phenotype was exacerbated by addition of an agonistic CD38‐binding antibody, suggesting that signaling through CD38 promotes this cell profile. Activated CD4+CD38+ cells had a bias towards IL‐13 secretion, but not other Th2 cytokines such as IL‐4 or IL‐5. In comparison, the CD4+CD38− cells had a clear bias towards secretion of Th1‐associated cytokines IFN‐γ and TNF. The existence of such CD4+CD38+ T cells may play an important role in pathologies such as asthma, which are associated with IL‐13, but not IL‐4 and IL‐5. Coupled with responsiveness to IL‐7 but not IL‐2, and the involvement of CD38 ligation, our results highlight a unique T‐cell subpopulation that does not fit into existing naive and memory cell paradigms.
Cyclometallated Palladium Diphosphane Compounds Derived from the Chiral Ligand (S)‐PhCH(Me)NMe2. Michael Addition Reactions to the Vinylidene Double Bond
Authors: Mosteiro Roberto , Fernández Alberto , Vázquez‐García Digna , López‐Torres Margarita , Rodríguez‐Castro Antonio , Gómez‐Blanco Nina , Vila José M. , Fernández Jesús J. 
Published: March 2011

AbstractTreatment of (S)‐PhCH(Me)NMe2 (1) with palladium(II) acetate in toluene gave the dinuclear cyclometallated complex [Pd{(S)‐C6H4CH(Me)NMe2‐C2,N}(μ‐OAc)]2 (2), inwhich the ligand is bonded to the palladium atom through the nitrogen phenyl carbon atoms. The reaction of 2 with aqueous sodium chloride gave the chloro‐bridged complex 3. The reaction of 3 with (R,R)‐DIOP [(4R,5R)‐4,5‐bis(diphenylphosphanylmethyl)‐2,2‐dimethyl‐1,3‐dioxolane], in a complex/phosphane 1:1 molar ratio, gave [{Pd[(S)‐C6H4CH(Me)NMe2‐C2,N]Cl}2(μ‐(R,R)‐DIOP)] (4). The reaction of 3 with (Ph2P)2C=CH2 (vdpp) in a 1:2 molar ratio in the presence of NH4PF6 or NaClO4 afforded [Pd{(S)‐C6H4CH(Me)NMe2‐C2,N}{(Ph2P)2C=CH2‐P,P′}][Y] [Y = PF6– (5); Y = ClO4– (6), respectively]. The treatment of 5 with acetylacetone in the presence of anhydrous sodium carbonate or with methanol afforded the addition products, [Pd{(S)‐C6H4CH(Me)NMe2‐C2,N}{(Ph2P)2CHCH2R‐P,P′}][PF6] [R = CH(COMe)2 (7); R = OMe (8), respectively], in good yield. The treatment of 6 with methyl acetoacetate and anhydrous sodium carbonate afforded the addition derivative [Pd{(S)C6H4CH(Me)NMe2C2,N}{(Ph2P)2CHCH2CH‐(COMe)(COOMe)‐P,P′}][ClO4] (9). The NMR spectra of the addition products showed that some of the resonances were duplicated due to the existence of optical isomers. The X‐ray crystal structure of complexes 2, 5, and 7 were determined by single‐crystal X‐ray diffraction analysis.
Synthesis, Structural Characterization and Metal Inclusion Properties of 18‐, 20‐ and 22‐Membered Oxaazacyclophanes and Oxaazacalix[4]arene Analogues: Macrocyclic Amine and Schiff Base Receptors with Variable NxOy Donor Sets
Authors: Moreno‐Corral Ramón , Höpfl Herbert , Machi‐Lara Lorena , Lara Karen O. 
Published: March 2011

AbstractA series of oxaazacyclophanes and oxaazacalix[4]arene analogues with 18‐, 20‐ and 22‐membered rings have been synthesized from diamine and dialdehyde building blocks and structurally characterized by spectroscopic methods. One diamine precursor and four macrocycles have additionally been analysed by single‐crystal X‐ray diffraction. Two of the oxaazacalix[4]arene analogues were employed for metal ion complexation studies based on UV/Vis absorption spectroscopy, showing both compounds to be able to form complexes with Cu2+ and Zn2+.
An Efficient Approach to 2‐Bromoalken‐3‐ols by Regioselective Bromohydroxylation Reaction of Simple Allenes with NBS
Authors: Kong Wangqing , Guo Binjie , Fu Chunling , Ma Shengming 
Published: March 2011

AbstractA regioselective bromohydroxylation reaction of simple allenes affording 2‐bromoalken‐3‐ols in moderate‐to‐good yields has been developed by using NBS as the electrophilic reagent in a mixture of 1,4‐dioxane/H2O (1:1) at room temperature. Through this study it has been concluded that the regioselectivity is determined by various factors including steric and electronic effects of the substituents of the allene moiety.
Bilateral parotid abscesses as the initial presentation of strongyloidiasis in the immunocompetent host
Authors: Tsai Yao‐Te , Yeh Chi‐Ju , Chen Yen‐An , Chen Yi‐Wei , Huang Shiang‐Fu 
Published: March 2011

AbstractBackgroundMost suppurative parotid abscesses are unilateral and result from bacterial infection via Stensen's duct. Formation of bilateral parotid abscesses rarely occur, and cases arising in the setting of parasite infection have not been described to date.Methods and ResultsA 41‐year‐old man presented with bilateral parotid abscesses and underwent incision and drainage of right‐sided swelling because of poor response to the aspiration drainage and intravenous antibiotic therapy. A nematode larva, morphologically consistent with Strongyloides stercoralis (S. stercoralis), was found in the cytologic examination, and bilateral abscesses regressed significantly after administration of Ivermectin.ConclusionWe report the first case of S. stercoralis infection presenting as bilateral parotid abscesses. This case expands the spectrum of diseases associated with S. stercoralis and suggests that clinicians, especially in the endemic regions, should consider S. stercoralis infection in the differential diagnosis of refractory parotid abscess. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Airway management before chemoradiation for advanced head and neck cancer
Authors: Langerman Alexander , Patel Riddhi M. , Cohen Ezra E. W. , Blair Elizabeth A. , Stenson Kerstin M. 
Published: March 2011

AbstractBackgroundPatients with upper aerodigestive tract tumors can have development of airway compromise both before and during chemoradiotherapy (CRT). Tracheotomy is the classic method for securing a safe airway, but tumor debulking may also be used.MethodsThis was a retrospective review of locoregionally advanced tumors of the base of tongue, larynx, or hypopharynx undergoing CRT between 1995 and 2007.ResultsForty‐two of the 109 patients presented with signs or symptoms of airway obstruction. Of these, 28 underwent tracheotomy before CRT, and 11 had tumor debulking. Two of the 11 patients who underwent debulking required tracheotomy within 1 year after CRT for persistent edema and fibrosis. Larynx tumors were more likely to require tracheotomy or debulking than other tumors (p = .01).ConclusionsDebulking is a safe and effective alternative to tracheotomy in select patients with tumor‐related airway obstruction before CRT. Patients who undergo debulking should be monitored closely for recurrence of airway compromise during and after CRT. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Quantification of volatile compounds in Chinese soy sauce aroma type liquor by stir bar sorptive extraction and gas chromatography–mass spectrometry
Authors: Fan Wenlai , Shen Haiyue , Xu Yan 
Published: March 2011

AbstractBACKGROUND: Considering the important of aroma compounds on the quality of baijiu, stir bar sorptive extraction (SBSE) coupled with gas chromatography–mass spectrometry was applied to the aromas analysis of baijiu (Chinese liquor).RESULTS: Based on the results of optimization, a total of 76 volatile compounds were identified from 14 Chinese liquors, including 25 esters, 10 alcohols, 9 aldehydes and ketones, 8 aromatic compounds, 5 furans, 3 nitrogen‐containing compounds, 6 acids, 4 phenols, 3 terpenes, 1 sulfide‐containing compound, 1 lactone, and 1 acetal. By principal component analysis based on quantification results, 14 Chinese liquor samples could be classified into three groups.CONCLUSION: SBSE is a fast, simple, effective, and reliable method for extracting volatile compounds from Chinese liquor. The chemometrics approach revealed that LJ liquor with soy sauce aroma could exhibit more prominent sauce flavor through extending the time of storage, and its peculiar manufacturing practice was responsible for the soy sauce flavor. Copyright © 2011 Society of Chemical Industry
Changes in pH, acids, sugars and other quality parameters during extended vine holding of ripe processing tomatoes
Authors: Anthon Gordon E , LeStrange Michelle , Barrett Diane M 
Published: March 2011

AbstractBACKGROUND: Two important quality attributes of processing tomatoes are pH and titratable acidity. These and other quality attributes can be affected by tomato fruit maturity and over‐maturity. We have determined the magnitude of these maturity effects in four processing tomato cultivars commonly grown in California.RESULTS: Allowing tomatoes to remain on the vine for up to 4 weeks after ripening resulted in an increase in fruit pH of between 0.01 and 0.02 unit per day for the four cultivars examined. The increase in pH was paralleled by a decrease in titratable acidity, due to a loss of citric acid. Glucose and fructose concentrations also declined with increasing maturity after ripening. Other quality parameters (color, lycopene, total pectin, pectin solubility, and Bostwick consistency) all showed little change.CONCLUSION: Vine holding of ripe fruit adversely affects quality, especially pH and titratable acidity. Recent problems with high tomato juice pH encountered by tomato processors in California could be the result of increased average fruit maturity at harvest. Copyright © 2011 Society of Chemical Industry
Critical care issues in patients after liver transplantation
Authors: Razonable Raymund R. , Findlay James Y. , O'Riordan Aisling , Burroughs Gordon S. , Ghobrial Mark R. , Agarwal Banwari , Davenport Andrew , Gropper Michael 
Published: March 2011

Abstract
The majority of patients who undergo liver transplantation (LT) spend some time in the intensive care unit during the postoperative period. For some, this is an expected part of the immediate posttransplant recovery period, whereas for others, the stay is more prolonged because of preexisting conditions, intraoperative events, or postoperative complications. In this review, 4 topics that are particularly relevant to the postoperative intensive care of LT recipients are discussed, with an emphasis on current knowledge specific to this patient group. Infectious complications are the most common causes of early posttransplant morbidity and mortality. The common patterns of infection seen in patients after LT and their management are discussed. Acute kidney injury and renal failure are common in post-LT patients. Kidney injury identification, etiologies, and risk factors and approaches to management are reviewed. The majority of patients will require weaning from mechanical ventilation in the immediate postoperative period; the approach to this is discussed along with the approach for those patients who require a prolonged period of mechanical ventilation. A poorly functioning graft requires prompt identification and appropriate management if the outcomes are to be optimized. The causes of poor graft function are systematically reviewed, and the management of these grafts is discussed. Liver Transpl 17:511-527, 2011. © 2011 AASLD.
BSA Adsorption on Differently Charged Polystyrene Nanoparticles using Isothermal Titration Calorimetry and the Influence on Cellular Uptake
Authors: Baier Grit , Costa Cristiane , Zeller Anke , Baumann Daniela , Sayer Claudia , Araujo Pedro H. H. , Mailänder Volker , Musyanovych Anna , Landfester Katharina 
Published: March 2011

AbstractBSA adsorption onto negatively and positively charged polystyrene nanoparticles was investigated. The nanoparticles were characterized in terms of particle size, zeta potential, surface group density, and morphology. The adsorption behavior of BSA on the particle surface, as a function of pH and overall charge of the particle, was studied using ITC. Different thermodynamic data such as enthalpy changes upon binding and stoichiometry of the systems were determined and discussed. The degree of surface coverage with BSA was calculated using the thermodynamic data. The cellular uptake of particles before and after BSA adsorption was studied using HeLa cells in the presence and absence of supplemented FCS in the cell culture medium. magnified image
Annihilation Upconversion in Cells by Embedding the Dye System in Polymeric Nanocapsules
Authors: Wohnhaas Christian , Turshatov Andrey , Mailänder Volker , Lorenz Steffen , Baluschev Stanislav , Miteva Tzenka , Landfester Katharina 
Published: March 2011

AbstractThe first energetically conjoined TTA‐assisted photon energy upconversion operating in cell tissue is described. The synthesized nanocapsules with the encapsulated UC dye system consisting of an emitter and a sensitizer show very efficient UC emission in aqueous dispersion under extremely low excitation intensity down to 0.05 W · cm−2 so that tissue and cells are not affected by the excitation light. The demonstrated sub‐linear intensity dependence of the UC emission is of crucial importance for life‐science applications as the UC photon could serve as a local or in situ optical excitation source for subsequent light‐triggered processes. magnified image
Amphiphilic Polysaccharide Nanogels as Artificial Chaperones in Cell‐Free Protein Synthesis
Authors: Sasaki Yoshihiro , Asayama Wakiko , Niwa Tatsuya , Sawada Shin‐ichi , Ueda Takuya , Taguchi Hideki , Akiyoshi Kazunari 
Published: March 2011

AbstractCell‐free protein synthesis is a promising technique for the rapid production of proteins. However, the application of the cell‐free systems requires the development of an artificial chaperone that prevents aggregation of the protein and supports its correct folding. Here, nanogel‐based artificial chaperones are introduced that improve the folding efficiency of rhodanese produced in cell‐free systems. Although rhodanese suffers from rapid aggregation, rhodanese was successfully expressed in the presence of the nanogel and folded to the enzymatically active form after addition of cyclodextrin. To validate the general applicability, the cell‐free synthesis of ten water‐soluble proteins was examined. It is concluded that the nanogel enables efficient expression of proteins with strong aggregation tendency. magnified image
Highly Efficient Intracellular Drug Delivery with a Negatively Charged Hyperbranched Polysulfonamine
Authors: Chen Suyun , Tan Zhonghua , Li Nan , Wang Ruibin , He Lin , Shi Yunfeng , Jiang Lei , Li Peiyong , Zhu Xinyuan 
Published: March 2011

AbstractEfficient intracellular translocation is achieved using an easily prepared hyperbranched polysulfonamine that remains negatively charged at physiological pH. Investigations on the cellular uptake mechanism and the subcellular distribution of PSA are reported. The in vitro cytotoxicity of PSA is found to be low. Using doxorubicin as a model drug, a PSA/drug complex is prepared by electrostatic interaction with a high drug payload that exhibits a controlled release in response to pH. Efficient intracellular drug delivery, strong growth inhibition of tumor cells, and low cytotoxicity to normal cells are observed. The results suggest a possible way to utilize anionic polymers for intracellular delivery of therapeutic moieties or drugs. magnified image
Amphiphilic PEG‐b‐PMCL‐b‐PDMAEMA Triblock Copolymers: From Synthesis to Physico‐Chemistry of Self‐Assembled Structures
Authors: Matter Yves , Enea Ramona , Casse Olivier , Lee Cameron C. , Baryza Jeremy , Meier Wolfgang 
Published: March 2011

AbstractA synthetic route toward a new family of amphiphilic mPEG‐b‐PMCL‐b‐PDMAEMA triblock copolymers is reported. Chemical structures and compositions are confirmed by 1H NMR and SEC. Polydispersity indices are typically <1.4, indicating good control of the reactions. The physicochemical parameters associated with mPEG‐b‐PMCL‐b‐PDMAEMA self‐assembled structures are investigated. Nanoparticles are prepared via a co‐solvent method, and parameters such as nanoparticle $\overline {M} _{{\rm w}} $, Nagg, A2, and Rh are calculated based on static and dynamic light scattering data. Critical aggregation concentrations for the polymers are determined by measuring surface tensions of polymer solutions. TEM is employed to visualize the morphology of the assemblies. magnified image
In situ Foaming Evolution of Flexible Polyurethane Foam Nanocomposites
Authors: Bernal M. Mar , Lopez‐Manchado Miguel Angel , Verdejo Raquel 
Published: March 2011

AbstractThe effect of both as‐produced and functionalised CNTs on the polymerisation evolution of water‐blown PU foams containing up to 0.3 wt.‐% CNTs was studied by in situ FT‐IR spectroscopy. FT‐IR revealed a decrease on the rate of isocyanate conversion as a function of loading fraction for both as‐grown and oxidised CNTs. This dependency suggested that the isocyanate conversion at the early stages of the reaction was governed by the kinetic effects imposed by the presence of the CNTs. The onset of microphase separation was accelerated by the addition of functionalised CNTs (f‐CNTs) but not by as‐produced CNTs due to the different surface functionalities. Measurements of the foaming viscoelastic properties showed an increase on the storage modulus with the CNT content, which indicated the reinforcement of the foam. magnified image
Effect of Maleated Compatibilizer on Performance of PLA/Wheat Straw‐Based Green Composites
Authors: Nyambo Calistor , Mohanty Amar K. , Misra Manjusri 
Published: March 2011

AbstractIn this study, the use of PLA‐g‐MA is investigated as a potential method for improving interfacial adhesion between agricultural residues and PLA, with the goal of enhancing mechanical properties. Compatibilization was achieved by using PLA‐g‐MA prepared via reactive extrusion. Green renewable and compatibilized PLA/wheat straw composites were extruded and injection‐molded. Addition of 3 and 5 phr PLA‐g‐MA to the composites resulted in significant improvements in tensile strength (20%) and flexural strength (14%) of the composites, matching that of the neat polymer. The observed improvement in strength was attributed to the good interfacial adhesion between the fiber and matrix. magnified image
Continuous Controlled Radical Polymerization of Methyl Acrylate in a Copper Tubular Reactor
Authors: Chan Nicky , Cunningham Michael F. , Hutchinson Robin A. 
Published: March 2011

AbstractThe use of copper tubing as both the reactor and as a catalyst source is demonstrated for continuous controlled radical polymerization of methyl acrylate at ambient temperature and at low solvent content of 30%. The high surface area provided by the copper walls mediates the reaction via the single electron transfer–living radical polymerization (SET‐LRP) mechanism. The polymerizations proceeded quickly, reaching 67% conversion at a residence time of 16 min. Ligand concentration could also be reduced without a sharp drop in polymerization rate, demonstrating the potential for decreased raw material and post‐process purification costs. Chain extension experiments conducted using synthesized polymer showed high livingness. The combination of living polymer produced at high polymerization rates at ambient temperature and low volatile organic solvent content demonstrate the potential of a copper reactor for scale up of SET‐LRP. magnified image
“Clip” and “Click” Chemistries Combination: Toward Easy PEGylation of Degradable Aliphatic Polyesters
Authors: Freichels Hélène , Pourcelle Vincent , Le Duff Cécile S. , Marchand‐Brynaert Jacqueline , Jérôme Christine 
Published: March 2011

Abstractα‐Methoxy‐ω‐alkyne poly(ethylene glycol) (PEG) was tagged with pendent N‐hydroxy‐succinimidyl activated esters by photografting of a molecular clip. This easily synthesized heterofunctional PEG was found to be a versatile building block for (i) conjugation with an amino derivative and (ii) grafting to azido functional aliphatic polyesters backbone by Huisgen's 1,3‐dipolar cycloaddition. This original combination of “clip” and “click” reactions provides a versatile and straightforward pathway for the synthesis of functional amphiphilic and degradable copolymers valuable for biomedical applications such as in drug‐delivery. magnified image
Highly Selective Colorimetric and Fluorometric Probes for Fluoride Ions Based on Nitrobenzofurazan‐containing Polymers
Authors: Hu Jinming , Li Changhua , Cui Yue , Liu Shiyong 
Published: March 2011

AbstractWe report on a novel colorimetric and fluorometric chemosensor for fluoride ions based on 4‐(2‐acryloyloxyethylamino)‐7‐nitro‐2,1,3‐benzoxadiazole (NBDAE)‐labeled polymers. Upon gradual addition of fluoride ions (F–), the green fluorescence emission of NBDAE moieties can be dramatically quenched, accompanied with the distinct colorimetric transition from green to yellow. NBDAE moieties are capable of selectively recognizing F– ions via hydrogen‐bonding (H‐bonds) interactions at low F– concentration and subjected to further deprotonation process at high F– concentration. NBDAE‐labeled polymers in organic solvents possess high selectivity and fluorescence “turn‐off” characteristics toward the sensing of F– ions with the detection limit down to ≈0.8 µM. magnified image
Influencing the morphology of polymer blends through graft copolymers
Authors: Braun D. , Fischer M. , Hellmann G.P. 
Published: March 2011

AbstractGraft copolymers have a potential as compatibilizers in two‐component thermoplastic polymer blends, and also as impact‐modifiers in one‐component thermoplastics. The compatibility of the blocks of the copolymer (i.e. the grafts and the main chain) with the chains of the matrix polymers must be adjusted carefully. Blends of various polymers, especially of polystyrene (PS) and poly(vinyl chloride) (PVC), with graft copolymers on the basis of polybutadiene are discussed. An excellent compatibilizer, for blends PS/PVC, is a block‐graft copolymer, derived from a diblock copolymer of Styrene and butadiene, with grafts of cyclohexyl methacrylate monomelic units.