bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Electrochemical Reactions of Organosilicon Compounds.
Authors: YOSHIDA J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Physical Chemistry of Solids
Authors: RAO C. N. R. , RAO K. J. , RAMASESHA S. , SARMA D. D. , YASHONATH S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Contaminated Aquatic Sediments and Waste Sites as Toxic Chemical Time Bombs
Authors: FOERSTNER U. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoinduced Charge Transfer Processes at Semiconductor Electrodes and Particles.
Authors: MEMMING R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Progress and Future Directions in the Theory of Strongly Interacting Polymer‐Solid Interfaces
Authors: CHAKRABORTY A. K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoinduced Charge Separation via Twisted Intramolecular Charge Transfer States.
Authors: RETTIG W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NMR Studies of the Structure and Properties of Cyclodextrins and Their Inclusion Complexes
Authors: INOUE Y. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Analysis of Inorganic and Organic Surfaces and Thin Films by Static Time‐of‐Flight Secondary Ion Mass Spectrometry (TOF‐SIMS)
Authors: BENNINGHOVEN A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Luminescent Labels, More than Just an Alternative to Radioisotopes?
Authors: MAYER A. , NEUENHOFER S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Effect of the Combined Substitution of NH+4 and Cl‐ on the Structure of [Cs0.8(NH4)0.2] 2TeBr5.6Cl0.4 Powder.
Authors: Belgaroui H. , Loukil M. , Karray R. , Salah A. Ben , Kabadou A. 
Published: August 2010

AbstractThe A2TeX6 (A: alkali metal; X: halogen) family represents a vast class of semiconductors and the influence of both cation and anion substitutions on the structure and on the bonding within the TeX62‐ anions is of great interest.
ChemInform Abstract: Chloride Derivatives of Lanthanide ortho‐Oxomolybdates: Part 3. Crystal Structures, Spectroscopic Studies, and Magnetic Properties of the LnCl[MoO4] Representatives with the Large Lanthanides (Ln: La, Ce, Pr).
Authors: Hartenbach Ingo , Schleid Thomas , Strobel Sabine , Dorhout Peter K. 
Published: August 2010

AbstractThe title compounds are prepared from mixtures of LnCl3 (Ln: La, Ce, Pr), Ln2O3, and MoO3 in molar ratios of 1:1:3 (900 °C, 6 d) and characterized by powder XRD, single crystal XRD, Raman spectroscopy, and magnetic measurements.
ChemInform Abstract: The New Neodymium(II) Oxide Chloride Oxoselenate(IV) Nd7O5Cl3[SeO3]4.
Authors: Zitzer Sabine , Schleid Thomas 
Published: August 2010

AbstractPale violet, needle‐shaped single crystals of the title compound are prepared from mixtures of Nd2O3, NdCl3, and SeO2 in the molar ratio of 3:1:4 using CsCl as a flux (silica ampule, 775 °C, 7 d).
ChemInform Abstract: Synthesis, Characterization, and Computational Study of MoSF4.
Authors: Nieboer jared , Mack Johnathan P. , Mercier Helene P. A. , Gerken Michael 
Published: August 2010

AbstractMoSF4 is synthesized from a slight excess of MoF6 and S(SiMe3)2 in CFCl3 (‐120 °C, 86% yield) and characterized by Raman, IR, and 19F NMR spectroscopy, and by single crystal XRD.
ChemInform Abstract: Ethyl 5‐Chloro‐2‐oxopent‐3‐ynoate, a New Acetylenic Dienophile in the Diels—Alder Reactions.
Authors: Koldobskii A. B. , Shilova O. S. , Godovikov I. A. , Kalinin V. N. 
Published: August 2010

AbstractTreatment of the lithium salt of propargyl chloride (I) with diethyl oxalate (II) at low temperatures under strictly controlled conditions provides the previously unknown ester (III) which undergoes Diels—Alder reactions with conjugated dienes.
ChemInform Abstract: Gold‐Catalyzed Dealkoxylative Carbocyclization/[3 + 3] Annulation Cascade of Acetal—Allene or Ketal—Allene Substrates.
Authors: Teng Tse‐Min , Lin Ming‐Shiun , Vasu Dhananjayan , Bhunia Sabyasachi , Liu Ting‐An , Liu Rai‐Shung 
Published: August 2010

AbstractAcetal‐allene or ketal‐allene compounds undergo the title cascade reaction with 2‐substituted allylsilanes, a phenol, or enolizable ketones to give a wide variety of tri‐ and tetracyclic carbocycles as well as oxapolycyclic compounds with good stereocontrol in general.
ChemInform Abstract: Ring Opening of Cyclic Vinylogous Acyl Triflates Using Stabilized Carbanion Nucleophiles: Claisen Condensation Linked to Carbon—Carbon Bond Cleavage.
Authors: Jones David M. , Lisboa Marilda P. , Kamijo Shin , Dudley Gregory B. 
Published: August 2010

AbstractTreatment of the cyclic triflates (I) and (VII) with carbanion nucleophiles provides acyclic alkynes bearing 1,3‐diketone, β‐keto ester, β‐keto phosphonate, or β‐keto phosphine oxide moieties.
ChemInform Abstract: Mild Arming and Derivatization of Natural Products via an In(OTf)3‐Catalyzed Arene Iodination.
Authors: Zhou Cong‐Ying , Li Jing , Peddibhotla Satyamaheshwar , Romo Daniel 
Published: August 2010

AbstractBacterial protein synthesis inhibitor anisomycin is not reactive, but its N‐Boc derivative (XVII) affords the expected iodide (XVIII) in high yield.
ChemInform Abstract: Asymmetric Rh(I)‐Catalyzed Addition of MIDA Boronates to N‐tert‐Butanesulfinyl Aldimines: Development and Comparison to Trifluoroborates.
Authors: Brak Katrien , Ellman Jonathan A. 
Published: August 2010

AbstractThe MIDA boronates are efficient coupling partners which allow formation of α‐branched amines in good yields with excellent enantioselectivity.
ChemInform Abstract: A Versatile Approach to 2‐Substituted 3‐Trifluoromethyl‐1,3‐diols Based on the Reaction of Trifluoroacetaldehyde Ethyl Hemiacetal with Enamines Derived from Aldehydes.
Authors: Funabiki Kazumasa , Furuno Yudai , Sato Fumiaki , Gonda Hiroshi , Kubota Yasuhiro , Matsui Masaki 
Published: August 2010

AbstractThe reaction of enamine (I) with ethyl hemiacetal (II) followed by acid hydrolysis and subsequent reduction of the intermediate aldehyde gives rise to the diastereomeric mixture of diols (III) and (IV).
ChemInform Abstract: The 1,3‐Diaminobenzene‐Derived Aminophosphine Palladium Pincer Complex {C6H3 [NHP(piperidinyl)2]2Pd(Cl)} — A Highly Active Suzuki—Miyaura Catalyst with Excellent Functional Group Tolerance.
Authors: Bolliger Jeanne L. , Frech Christian M. 
Published: August 2010

AbstractThe new protocol is an improvement over previously reported methods due to its significantly broadened applicability.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of 2,3‐Naphthoxadisilole with Aryl Halides.
Authors: Ding Han , Chen Yali , Cao Weiguo , Wu Kaicheng , Chen Jie , Lee Albert W. M. 
Published: August 2010

AbstractFor the first time oxadisilole is used as partner in the palladium‐catalyzed cross‐coupling reaction.
ChemInform Abstract: Rapid Access to 1‐Methyleneindenes via Palladium‐Catalyzed Tandem Reactions of 1‐(2,2‐Dibromovinyl)‐2‐alkynylbenzenes with Arylboronic Acids.
Authors: Ye Shengqing , Yang Xiaodi , Wu Jie 
Published: August 2010

AbstractThe novel route to title compounds, e.g. (III), proceeds under mild conditions and with high selectivity.
ChemInform Abstract: Triethanolamine‐Mediated Palladium‐Catalyzed Regioselective C‐2 Direct Arylation of Free NH‐Pyrroles.
Authors: Jafarpour Farnaz , Rahiminejadan Soraya , Hazrati Hamideh 
Published: August 2010

AbstractThe straightforward and cost‐effective approach can also be applied to N‐substituted pyrroles.
ChemInform Abstract: Ene Reactions Between Two Alkynes? Doors Open to Thermally Induced Cycloisomerization of Macrocyclic Triynes and Enediynes.
Authors: Gonzalez Ivan , Pla‐Quintana Anna , Roglans Anna , Dachs Anna , Sola Miquel , Parella Teodor , Farjas Jordi , Roura Pere , Lloveras Vega , Vidal‐Gancedo Jose 
Published: August 2010

AbstractA domino process is described combining an ene reaction between two alkynes and a Diels—Alder cycloaddition of the vinylallene formed.
ChemInform Abstract: The Application of Poly(N,N′‐dibromo‐N‐ethyl‐benzene‐1,3‐disulfonamide) and N,N,N′,N′‐Tetrabromobenzene‐1,3‐disulfonamide as Catalysts for One‐Pot Synthesis of 2‐Aryl‐1‐arylmethyl‐1H‐1,3‐benzimidazoles and 1,5‐Benzodiazepines, and New Reagents for Synthesis of Benzimidazoles.
Authors: Ghorbani‐Vaghei Ramin , Veisi Hojat 
Published: August 2010

AbstractTBBDA and its polymeric analogue PBBS are found to promote the condensation of o‐phenylene diamine (I) with aldehydes and ketones under various conditions.
ChemInform Abstract: Synthesis and Antidepressant Evaluation of Five Novel Heterocyclic Tryptophan‐Hybrid Derivatives.
Authors: Elmegeed Gamal A. , Baiuomy Ayman R. , Abdelhalim Mervat M. , Hana Hanaa Y. 
Published: August 2010

AbstractFacile syntheses of new bi‐ and triheterocyclic tryptophan‐hybrid systems are given.
ChemInform Abstract: Preparation of Substituted Oxazoles by Ritter Reactions of α‐Oxo Tosylates.
Authors: Lai Ping‐Shan , Taylor Mark S. 
Published: August 2010

AbstractLewis acid catalyzed Ritter reaction of α‐oxo tosylates, trifluoroacetates and alcohols with nitriles under optimized conditions affords trisubstituted oxazole products in good to excellent yields.
ChemInform Abstract: Solvent‐Free Multicomponent Synthesis of Pyranopyrazoles: Per‐6‐amino‐β‐cyclodextrin as a Remarkable Catalyst and Host.
Authors: Kanagaraj Kuppusamy , Pitchumani Kasi 
Published: August 2010

AbstractThe method is highly efficient, since it needs only a very small amount of PAC.
ChemInform Abstract: Synthesis of Substituted Methyl 5,5‐Polymethylene‐2,4‐dioxotetrahydropyran‐3‐carboxylates.
Authors: Kirillov N. F. , Melekhin V. S. , Shurov S. N. , Plotnikov A. V. , Vakhrin M. I. , Maiorova O. A. 
Published: August 2010

AbstractThe title compounds (VI) (8 examples) are obtained in the reaction of malonates (IV) with zinc and several aromatic aldehydes (V).
ChemInform Abstract: Synthesis and Some Transformations of 6(8)‐Substituted 4‐Hydrazino‐2‐methylquinolines.
Authors: Avetisyan A. A. , Aleksanyan I. L. , Ambartsumyan L. P. 
Published: August 2010

AbstractThe title compounds (III) are obtained by reaction of the corresponding 4‐chloro‐2‐methylquinolines (I) with hydrazine hydrate.
ChemInform Abstract: Synthesis of Highly Substituted Cyclobutane Fused‐Ring Systems from N‐Vinyl β‐Lactams Through a One‐Pot Domino Process.
Authors: Cheung Lawrence L. W. , Yudin Andrei K. 
Published: August 2010

AbstractA domino [3.3]‐rearrangement/6π‐electrocyclization process furnishes highly substituted pyridine‐fused cyclobutane derivatives and thus provides an promising method for preparation of fused heterocycles.
ChemInform Abstract: 3‐Substituted 2‐Trifluoromethylimidazo[1,2‐a]pyridines.
Authors: Sokolov V. B. , Aksinenko A. Yu. , Epishina T. A. , Goreva T. V. 
Published: August 2010

AbstractPreviously unknown 3‐fluoro‐2‐trifluoromethylimidazo[1,2‐a]pyridines (IV) are synthesized via cyclization of readily available imines (III).
ChemInform Abstract: Synthesis of a Novel Tricyclic 1,2,3,4,4a,5,6,10b‐Octahydro‐1,10‐phenanthroline Ring System and CXCR4 Antagonists with Potent Activity Against HIV‐1.
Authors: Catalano John G. , et al. et al. 
Published: August 2010

AbstractStereorandom and diastereoselective syntheses of novel title ring system are described.
ChemInform Abstract: Properties of 3,3‐Dialkyl‐3,4‐dihydroisoquinoline Cyclic Azomethines.
Authors: Surikova O. V. , Mikhailovskii A. G. , Vakhrin M. I. 
Published: August 2010

AbstractReaction of the title dihydroisoquinolines (I) with esters or amides of iodoacetic acid gives stable quaternary ammonium salts (III), which appear to be suitable dipoles in [3 + 2] cycloaddition reactions.
ChemInform Abstract: A Novel and Efficient One‐Pot Synthesis of 2‐Aminopyrimidinones and Their Self‐Assembly.
Authors: Bararjanian Morteza , Balalaie Saeed , Rominger Frank , Barouti Sanaz 
Published: August 2010

AbstractA three‐component reaction of benzaldehydes, cyanoacetate and guanidinium carbonate affords the pyrimidine derivatives (10 examples).
ChemInform Abstract: Synthesis of Pyrimido[1,2‐a]benzimidazoles from Ethyl 2‐Ethoxymethylidene‐3‐oxo‐3‐(polyfluoroalkyl)propionates.
Authors: Goryaeva M. V. , Burgart Ya. V. , Saloutin V. I. 
Published: August 2010

AbstractThe cyclization of polyfluoroalkylpropionates (I) with benzimidazol‐2‐amine (II) follows two concurrent pathways with participation of the fluoroacyl or ethoxycarbonyl fragments, respectively.
ChemInform Abstract: Synthesis of Unexpected Pyrrolo[2,3‐b]quinoxaline‐2‐carbaldehydes via Sonogashira Coupling Reaction.
Authors: Keivanloo Ali , Bakherad Mohammad , Rahimi Amin 
Published: August 2010

AbstractPd‐catalyzed reaction of 3‐chloroquinoxalin‐2‐amines with propargyl bromide proceeds in the presence of wet morpholine to give the title compounds (III) unexpectedly.
ChemInform Abstract: Ketene Organoelement Derivatives. Synthesis of Bis(1‐R‐2‐oxovinyl)silanes and Germanes (R: SiMe3, GeMe3, SnMe3).
Authors: Gruener S. V. , Ezhov R. N. , Petrosyan V. S. 
Published: August 2010

AbstractEarlier unknown 1,3‐bisketene organo‐element compounds (III) are synthesized.
ChemInform Abstract: Hydrazinophosphonates and Hydrazinobisphosphonates: Novel Mitsunobu and Arbuzov‐Type Multicomponent Application of the Morrison—Brunn—Huisgen Betaine.
Authors: Alizadeh Abdolali , Rostamnia Sadegh 
Published: August 2010

AbstractThe reaction of the zwitterion, generated from DIAD and trialkylphosphite, with aroyl, phosphoryl, and sulfonyl chlorides produces the expected fully substituted hydrazines in good to excellent yields.
ChemInform Abstract: Synthesis and Biological Activity of New 2‐[(3‐Aminopropyl)dimethylsilyl]‐5‐trialkylgermylfurans.
Authors: Ignatovich L. , Romanovs V. , Shestakova I. , Domrachova I. , Popelis J. , Lukevics E. 
Published: August 2010

AbstractMost of the synthesized title compounds (III) (20 examples) exhibit high cytotoxic activity.
ChemInform Abstract: Dermacozines, a New Phenazine Family from Deep‐Sea Dermacocci Isolated from a Mariana Trench Sediment
Authors: Jaspars Marcel , et al. et al. 
Published: August 2010

Abstractisolation, structure elucidation and cytotoxicity screening of dermacozines A (Ia), B (Ib), C (Ic), D (II), E (IIIa), F (IIIb) and G (IIIc)
ChemInform Abstract: Five New 2‐Arylbenzofuran Derivatives from Morus wittiorum
Authors: Tan Yong‐Xia , Gong Ting , Liu Chao , Chen Ruo‐Yun , Yu De‐Quan 
Published: August 2010

Abstractstructure, antioxidant and antiinflammatory activities of wittifurans A‐C (Ia)‐(Ic), F (Id) and G (Ie)
A simple chromatographic route for the isolation of meso diaminopimelic acid
Authors: Tóth Gábor K. , Hetényi Anasztázia , Ilisz István , Péter Antal 
Published: August 2010

AbstractMeso diaminopimelic acid is an important noncoded amino acid found in Gram‐negative bacterial peptidoglycan. In spite of its importance, this stereoisomer is not available commercially. A simple, economical procedure was developed for the isolation of pure meso diaminopimelic acid via an high‐performance liquid chromatography separation. In our new approach, the underivatized three isomers of diaminopimelic acid were separated on a crown ether‐based chiral stationary phase. For the structure identification, 1H NMR spectroscopy was applied. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
Incorporation of Heavy Metals Bioavailability into Risk Characterization
Authors: Ryu Hyerim , Chung Jae Shik , Nam Taekwoo , Moon Hee Sun , Nam Kyoungphile 
Published: August 2010

AbstractThe bioavailability of field‐aged Cd and Cu was calculated, and compared to the total concentrations determined by acid digestion. Only 0.60–4.15% for Cd and 0.59–9.43% for Cu were found to be bioavailable when determined by stomach‐phase extraction. The incorporation of bioavailability reduced more than 90% of the calculated risk of the metals at the site of study. It should be noted that such a reduction may not be generalized and the site‐specific bioavailability needs to be determined case by case.
Effect of radiotherapy boost and hypofractionation on outcomes in ductal carcinoma in situ
Authors: Wai Elaine S. , Lesperance Mary L. , Alexander Cheryl S. , Truong Pauline T. , Culp Matthew , Moccia Patricia , Lindquist Jennifer F. , Olivotto Ivo A. 
Published: August 2010

AbstractBACKGROUND:Boost radiotherapy (RT) improves outcomes for patients with invasive breast cancer, but whether this is applicable to patients with pure ductal carcinoma in situ (DCIS) is unclear. This study examined outcomes from whole breast RT, with or without a boost, and the impact of different dose‐fractionation schedules in a population‐based cohort of women with pure DCIS treated with breast‐conserving surgery (BCS).METHODS:Data was analyzed for 957 subjects diagnosed between 1985 and 1999. RT use was analyzed over time. Ten‐year Kaplan‐Meier local control (LC), breast cancer specific survival (BCSS), and overall survival (OS) were compared using the log‐rank test. Cox regression modeling of LC was performed.RESULTS:Median follow‐up was 9.3 years. Of the patient cohort 475 (50%) had no RT (NoRT) after BCS, 338 (35%) had RT without a partial breast boost (RTNoB), and 144 (15%) had RT with boost (RT + B). Subjects with risk factors of local recurrence were more likely to receive RT. Subjects receiving adjuvant RT had a trend toward improved LC (15‐year LC: NoRT 87%; RTNoB 94%; RT + B 91%; P = .065). Multivariable analysis showed that RT with or without a boost was significantly associated with improved LC (HR, 0.29 and 0.38, respectively, compared with NoRT, P = .025), with no difference associated with a boost or different dose‐fractionation schedules.CONCLUSIONS:Adjuvant RT improves local control in patients with DCIS treated with BCS. Hypofractionation is as effective as standard fractionation schedules. Boost RT was not associated with improved LC compared with whole breast RT alone. Cancer 2011. © 2010 American Cancer Society.
Zoledronic acid use in cancer patients
Authors: Coleman Robert , Cook Richard , Hirsh Vera , Major Pierre , Lipton Allan 
Published: August 2010

AbstractBone is the most common site for metastasis from solid tumors, and the majority of patients will develop bone metastases during the natural course of their disease. Bisphosphonates are an effective treatment for preventing skeletal‐related events in patients with bone metastases and may preserve functional independence and quality of life. Although several bisphosphonates have been investigated in patients with solid tumors, only zoledronic acid (ZOL) is approved by the US Food and Drug Administration and the European Medicines Agency for preventing skeletal‐related events in patients across a broad range of solid tumors. In addition, bisphosphonates, notably ZOL, prevent cancer treatment‐induced bone loss in breast and prostate cancer patients who are receiving endocrine therapy. It also has been demonstrated that ZOL directly and indirectly inhibits cancer cell growth in vitro and growth and tumorigenesis in animal model systems. These properties may produce clinically meaningful benefits. In recent clinical studies in patients with cancer, ZOL improved overall and prolonged disease‐free survival. Ongoing clinical trials in patients with solid tumors will provide further insight into the potential of ZOL to prevent distant metastases and improve survival. Cancer 2011. © 2010 American Cancer Society.
Characteristics of the coexistence of melanoma and renal cell carcinoma
Authors: Maubec Eve , Chaudru Valérie , Mohamdi Hamida , Grange Florent , Patard Jean‐Jacques , Dalle Stéphane , Crickx Béatrice , Paillerets Brigitte Bressac‐de , Demenais Florence , Avril Marie‐Françoise 
Published: August 2010

AbstractBACKGROUND:Patients with melanoma (MM) have an increased risk of kidney cancer, and there is an excess risk of MM among patients with renal cell carcinoma (RCC). The objective of the current study was to analyze a series of 42 patients with both MM and RCC to identify clinical and pathologic features as well as risk factors of this association.METHODS:Clinical and pathologic characteristics of 42 patients who developed both MM and RCC (the MM + RCC series) were compared with 2 published series in each cancer alone: a series of 293 patients with MM (MM series) and a series of 1527 patients with RCC (RCC series).RESULTS:RCC was diagnosed concomitantly or after MM in 83% of patients in the MM + RCC series. Those patients displayed a high proportion of asymptomatic RCC at diagnosis (70%) and a higher frequency of stage I tumors (61%) than patients in the RCC series. Compared with the MM series, patients in the MM + RCC series more often were men, had a higher frequency of blond/red hair, had poor tanning ability, and had a higher number of nevi. In addition, patients in the MM + RCC series had a high aggregation of other malignancies (mainly skin cancers) and a significantly higher frequency of family history of MM (P = .005). Only 2 cyclin‐dependent kinase 2A gene (CDKN2A) germline mutations were identified among patients in the MM + RCC series who also were members of MM‐prone families.CONCLUSIONS:The high aggregation of cancers among patients in the MM + RCC series and the familial clustering of MM argued for a genetic predisposition that may be partly independent of CDKN2A. Cancer 2010. © 2010 American Cancer Society.