bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Creation of a High‐Valent Manganese Species on Hydrotalcite and Its Application to the Catalytic Aerobic Oxidation of Alcohols.
Authors: Nagashima Kohji , Mitsudome Takato , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi 
Published: March 2011

AbstractA high‐valent Mn oxide species is synthesized on the surface of hydrotalcite by treatment of the corresponding Mn compound with KOH.
ChemInform Abstract: A Simple and Effective Method for α‐Hydroxylation of β‐Dicarbonyl Compounds Using Oxone as an Oxidant Without a Catalyst.
Authors: Yu Jun , Cui Jian , Zhang Chi 
Published: March 2011

AbstractA wide variety of cyclic β‐dicarbonyl compounds is efficiently hydroxylated at the α‐position simply using Oxone without catalyst.
ChemInform Abstract: Efficient Carboazidation of Alkenes Using a Radical Desulfonylative Azide Transfer Process.
Authors: Weidner Karin , Giroult Andre , Panchaud Philippe , Renaud Philippe 
Published: March 2011

AbstractIn this paper a new class of reagents that allows an atom‐economical carboazidation reaction to be run under tin‐free conditions is prepared.
ChemInform Abstract: A One‐Pot Conversion of Carboxylic Acids into Nitriles Catalyzed by PEG400 under Microwave Irradiation.
Authors: Cao Yu‐Qing , Qu An‐Li , Liu Rui‐Yan , Duan Chun‐Ming 
Published: March 2011

AbstractThe new efficient title method is inexpensive, practical, with less pollution and includes an easy work‐up.
ChemInform Abstract: General and Highly Active Catalyst for Mono and Double Hiyama Coupling Reactions of Unreactive Aryl Chlorides in Water.
Authors: Lee Dong‐Hwan , Jung Ji‐Young , Jin Myung‐Jong 
Published: March 2011

AbstractA new β‐ketiminatophosphane Pd‐complex is found to be highly effective in the mono and double Hiyama coupling reactions of unactivated aryl chlorides (I), (IV) and (VII).
ChemInform Abstract: Bimetallic Catalysis Involving Dipalladium(I) and Diruthenium(I) Complexes.
Authors: Das Raj K. , Saha Biswajit , Rahaman S. M. Wahidur , Bera Jitendra K. 
Published: March 2011

AbstractA binuclear Pd catalyst containing amide‐tethered naphthyridinylferrocene ligands as well as a similar binuclear Ru catalyst are synthesized.
ChemInform Abstract: A General and Efficient Iridium‐Catalyzed Hydroformylation of Olefins.
Authors: Piras Irene , Jennerjahn Reiko , Jacksell Ralf , Spannenberg Anke , Franke Robert , Beller Matthias 
Published: March 2011

AbstractAn iridium—phosphine complex efficiently catalyzes the hydroformylation of terminal olefins to predominantly give linear aldehydes from aliphatic olefins (Ib) ‐ (Ie), but branched aldehydes from aromatic olefin (Ia).
ChemInform Abstract: Ligand‐Assisted Rate Acceleration in Lanthanum(III) Isopropoxide Catalyzed Transesterification of Carboxylic Esters.
Authors: Hatano Manabu , Furuya Yoshiro , Shimmura Takumi , Moriyama Katsuhiko , Kamiya Sho , Maki Toshikatsu , Ishihara Kazuaki 
Published: March 2011

AbstractThe catalyst is effective in the selective esterification of a variety of primary, secondary and tertiary alcohols including sterically demanding ones.
ChemInform Abstract: Iron‐Catalyzed Reductive Aryl—Alkenyl Cross‐Coupling Reactions.
Authors: Czaplik Waldemar M. , Mayer Matthias , Jacobi von Wangelin Axel 
Published: March 2011

AbstractThe simple precatalyst system FeCl3/TMEDA is effectively applied to cross‐coupling reactions of various arylmagnesium bromides and alkenyl bromides.
ChemInform Abstract: Efficient and Clean Gold‐Catalyzed One‐Pot Selective N‐Alkylation of Amines with Alcohols.
Authors: He Lin , Lou Xia‐Bing , Ni Ji , Liu Yong‐Mei , Cao Yong , He He‐Yong , Fan Kang‐Nian 
Published: March 2011

AbstractA wide range of aromatic and aliphatic tertiary amines is prepared using Au‐TiO2 with very small particles.
ChemInform Abstract: (Cyclopentadienyl)ruthenium‐Catalyzed Regio‐ and Enantioselective Decarboxylative Allylic Etherification of Allyl Aryl and Alkyl Carbonates.
Authors: Austeri Martina , Linder David , Lacour Jerome 
Published: March 2011

AbstractThe combination of a ruthenium complex with chiral pyridyloxazoline ligand POX catalyzes the title intra‐ or intermolecular reactions with high enantioselectivities and high regioselectivities for the branched products.
ChemInform Abstract: 1,3‐Bis(2,4,6‐trimethylphenyl)imidazolium Chloride in Combination with Triethylamine: An Improved Catalytic System for Hydroacylation/Reduction of Activated Ketones.
Authors: Sreenivasulu M. , Kumar K. Arun , Reddy K. Sateesh , Kumar K. Siva , Kumar P. Rajender , Chandrasekhar K. B. , Pal Manojit 
Published: March 2011

AbstractA combination of triethylamine and an NHC‐catalyst, generated in situ, efficiently promotes the reduction of α‐keto esters with benzaldehyde as hydrogen acceptor.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling Reaction of Aryl(trialkyl)silanes with Aryl Chlorides and Tosylates.
Authors: Tang Shi , Takeda Masahide , Nakao Yoshiaki , Hiyama Tamejiro 
Published: March 2011

AbstractArylsilanes (V) are readily prepared from silane (III) and successfully used as arylating agents in the cross‐coupling reaction with tosylates (VIa)—(VIc) and chlorides (VId)—(VIj).
ChemInform Abstract: Lewis‐Acid‐Mediated Domino Reactions of Bis(diacetoxymethyl)‐Substituted Arenes and Heteroarenes.
Authors: Clement J. Arul , Sivasakthikumaran Ramakrishnan , Mohanakrishnan Arasambattu K. , Sundaramoorthy S. , Velmurugan Devadasan 
Published: March 2011

AbstractThe domino reaction of aryl or heteroaryl tetraacetates with heteroarenes in the presence of Lewis acid affords annulated heteroarenes.
ChemInform Abstract: A Flexible Route to 4‐Substituted β‐Lactams.
Authors: Quiclet‐Sire Beatrice , Zard Samir Z. 
Published: March 2011

AbstractA variety of 4‐substituted β‐lactams are synthesized by radical addition‐transfer of N‐acyl‐protected 4‐S‐xanthylazetidinones to unactivated olefins.
ChemInform Abstract: Cu2O Nanocubes Catalyzed Difunctionalization Reaction of Vinyl Arenes with Cyclic Ethers.
Authors: Kim Jee Young , Park Ji Chan , Song Hyunjoon , Park Kang Hyun 
Published: March 2011

AbstractWell designed, uniform Cu2O nanoparticles catalyze the regioselective oxyalkylation of various vinyl arenes under mild conditions.
ChemInform Abstract: Dynamic Kinetic Asymmetric Domino Oxa‐Michael/Carbocyclization by Combination of Transition‐Metal and Amine Catalysis: Catalytic Enantioselective Synthesis of Dihydrofurans.
Authors: Lin Shuangzheng , Zhao Gui‐Ling , Deiana Luca , Sun Junliang , Zhang Qiong , Leijonmarck Hans , Cordova Armando 
Published: March 2011

AbstractThe highly enantioselective reaction is promoted by PdCl2 and proline‐derived organocatalyst with PhCOOH as an additive.
ChemInform Abstract: Multiple Approaches to Enantiopure Spirocyclic Benzofuranones Using Organocatalytic Cascade Reactions.
Authors: Cassani Carlo , Tian Xu , Escudero‐Adan Eduardo C. , Melchiorre Paolo 
Published: March 2011

AbstractThree distinct aminocatalytic cascade reactions leading to enantiomerically pure spirocyclic benzofuranones ar developed.
ChemInform Abstract: Convergent Approach to Nonsymmetrical 2,5‐Diester Pyrroles.
Authors: Levesque Eric , Campeau Louis‐Charles , Gauvreau Danny 
Published: March 2011

AbstractThe synthesis of title pyrroles (IV) is based on a Rh‐catalyzed NH‐insertion followed by a one‐pot zinc‐mediated deprotection cyclization sequence.
ChemInform Abstract: Rhodium/Diene‐Catalyzed Asymmetric Arylation of N‐Sulfonyl Indolylimines: A New Access to Highly Optically Active α‐Aryl 3‐Indolyl‐methanamines.
Authors: Yang Hong‐Yu , Xu Ming‐Hua 
Published: March 2011

AbstractThe first example of catalytic asymmetric arylation of title compounds (I) by using Rh(I) and bicyclo[3.3.0]diene ligand is reported.
ChemInform Abstract: The First Syntheses of Enantiopure 2,2′‐Biindoline.
Authors: Wales Steven M. , Willis Anthony C. , Keller Paul A. 
Published: March 2011

AbstractThe first two syntheses of enantiopure 2,2′‐biindoline (V) using bioxirane (II) and biaziridine (VI) as the chiral precursors are described.
ChemInform Abstract: Efficient and Metal‐Free Friedel—Crafts Alkylation of Indoles with Allyl Acetate Mediated by TFE.
Authors: Liu Zhe , Liu Li , Wu Yan‐Chao , Wang Dong 
Published: March 2011

AbstractThe chemoselective Friedel—Crafts allylation of indoles (I) and (IV) proceeds under mild conditions in trifluoroethanol providing the corresponding C‐3 allylated products in satisfactory to very good yields.
ChemInform Abstract: Iron/Palladium‐Catalyzed Intramolecular Hydroamination: An Expedient Synthesis of Pyrrole‐Annulated Coumarin and Quinolone Derivatives.
Authors: Majumdar K. C. , De Nirupam , Roy B. 
Published: March 2011

AbstractA straightforward and high‐yielding approach to the heterocyclic skeletons is achieved through a Pd/Fe‐catalyzed cyclization of acetylenic amines of type (I) and (III).
ChemInform Abstract: A Concise and Flexible Diastereoselective Approach to Heteroring‐Fused Isoindolinones.
Authors: Ahn Gang , Lorion Magali , Agouridas Vangelis , Couture Axel , Deniau Eric , Grandclaudon Pierre 
Published: March 2011

AbstractA sequence involving metalation of N‐chloroalkylated isoindolinones (I) and (IV), subsequent interception with aldehydes (II) or tosylimine (V) and ultimate intramolecular annulation allows the diastereoselective synthesis of the title compounds (III) and (VI).
ChemInform Abstract: Synthesis of 2,2′‐(2‐Oxoimidazolidine‐4,5‐diylidene)diacetates.
Authors: Mukovoz P. P. , Kozminykh V. O. , Nozdrin I. N. , Kozminykh E. N. 
Published: March 2011

AbstractCompound (II), which can be prepared by condensation of 2 equiv.
ChemInform Abstract: Unexpected Regioselectivity in Cycloisomerization of 2‐Alkynyl‐3‐nitrothiophenes.
Authors: Cikotiene Inga , Sazinas Rokas , Mazeikaite Rita , Labanauskas Linas 
Published: March 2011

AbstractOptimized reaction conditions using AuCl3 or silver trifluoroacetate as the catalyst are developed for the cycloisomerization of 2‐alkynyl‐3‐nitrothiophenes (I) or the corresponding isomers (III) to give thienoisoxazoles (II) and (IV) in moderate to good yields.
ChemInform Abstract: α,α‐Diarylprolinol‐Derived Chiral Ionic Liquids: Recoverable Organocatalysts for the Domino Reaction Between α,β‐Enals and N‐Protected Hydroxylamines.
Authors: Maltsev Oleg V. , Kucherenko Alexandr S. , Chimishkyan Alexandr L. , Zlotin Sergei G. 
Published: March 2011

AbstractDiarylprolinol‐derived chiral ionic liquid (IPROS) represents a novel efficient organocatalyst for the domino reaction of α,β‐enals with hydroxylamines.
ChemInform Abstract: Direct Preparation of Heteroaromatic Compounds from Alkenes.
Authors: Donohoe Timothy J. , Kabeshov Mikhail A. , Rathi Akshat H. , Smith Ian E. D. 
Published: March 2011

AbstractAromatic heterocycles, such as thiazoles (III), imidazoles (V) and indole derivative (VII) are synthesized directly from alkenes (I) via a ketoiodination—cyclization protocol.
ChemInform Abstract: Simple Selective Synthesis of 2,4‐ and 2,6‐Diarylpyridines Through Metal‐Free Cyclocondensation of Aromatic Ketones with Ammonium Acetate.
Authors: Liu Jin , Wang Chuanxin , Wu Liansheng , Liang Fen , Huang Guosheng 
Published: March 2011

AbstractUnder optimized conditions, acetophenones (I) and analogous ketones (III) afford 2,4‐ and 2,6‐diarylpyridines, respectively.
ChemInform Abstract: Gold(I)‐Catalyzed Formation of Dihydroquinolines and Indoles from N‐Aminophenyl Propargyl Malonates.
Authors: Gronnier Colombe , Odabachian Yann , Gagosz Fabien 
Published: March 2011

AbstractAn efficient synthesis of exo‐methylenetetrahydroquinolines [cf.
ChemInform Abstract: Novel, Versatile Three‐Step Synthesis of 1,2,3,4,10,10a‐Hexahydropyrazino[1,2‐a]indoles by Intramolecular Carbene‐Mediated C—H Insertion.
Authors: Krogsgaard‐Larsen Niels , Begtrup Mikael , Herth Matthias M. , Kehler Jan 
Published: March 2011

AbstractThe synthesis of title compounds (V) is based on an intramolecular carbene‐mediated C—H insertion in phenylpiperazine‐derived tosylhydrazones.
ChemInform Abstract: Synthesis of Substituted 4‐Oxo‐3,4‐dihydrothieno[3,4‐d]pyrimidines and Comparison of Their Properties with Those of Positionally Isomeric Thienopyrimidinones and Benzo Isosteres.
Authors: Zadorozhny A. V. , Turov A. V. , Kovtunenko V. A. 
Published: March 2011

AbstractTitle compound (III) is prepared by a new method giving increased yield.
ChemInform Abstract: An Alternative Synthesis of 2‐Alkylidene‐3,4‐dihydro‐2H‐1,4‐benzoxazines by Intramolecular Gold‐Catalyzed Hydroalkoxylation of 2‐(Prop‐2‐yn‐1‐ylamino)phenols.
Authors: Manzo Angelo M. , Perboni Alcide , Broggini Gianluigi , Rigamonti Micol 
Published: March 2011

AbstractCyclizations of substrates (I) and (III) under conditions A) gives the target benzoxazines.
ChemInform Abstract: 1,2,4‐Triazines — Products of Reaction of Thiocarbohydrazide and Its Alkyl(Aryl)‐Substituted Derivatives with 1,2‐Dicarbonyl Compounds.
Authors: Alekseyev V. V. , Lagoda I. V. , Yakimovich S. I. , Yegorova M. B. 
Published: March 2011

AbstractThe reaction of thiocarbohydrazides (I) with 1,2‐dicarbonyl compounds of type (II) or (IV) leads to the formation of triazines.
ChemInform Abstract: Asymmetric Induction in the Reactions of Azinones with C‐Nucleophiles.
Authors: Chupakhin O. N. , Egorov I. N. , Rusinov V. L. , Slepukhin P. A. 
Published: March 2011

AbstractThe reactions of triazinones (I) and (VII) with amino acid chlorides and indole lead to diastereomerically pure adducts (VI) and (X), respectively.
ChemInform Abstract: Rhodium‐Catalyzed Allene Amidation: A Facile Entry into 2‐Amidoallylcations for Unusual [3 + 3] Annulation Reactions.
Authors: Stoll Armin H. , Blakey Simon B. 
Published: March 2011

AbstractRegio‐ and stereoselective [3 + 3] cycloaddition reactions initiated by allene sulfamidation provide highly functionalized heterocycles in a modular fashion.
ChemInform Abstract: A Convenient Synthetic Route from Isatin N‐Mannich Bases to Nitrogen‐Containing Derivatives of Isoindigo.
Authors: Bogdanov Andrei V. , Mironov Vladimir F. , Musin Lenar I. , Musin Rashid Z. , Krivolapov Dmitry B. , Litvinov Igor A. 
Published: March 2011

AbstractThis simple procedure involves a novel deoxygenation reaction of isatins (I) with hexaethylphosphorous triamide furnishing the bis(aminomethyl)isoindigos (II) under mild conditions in a short reaction time.
ChemInform Abstract: Synthetic Studies of Superstolide A: A Carbohydrate Based Synthesis of the C21—C26 Segment.
Authors: Pal Rita , Rahaman Hasibur , Mohapatra D. K. , Gurjar Mukund K. 
Published: March 2011

AbstractA chiral pool approach to the title segment (IX) is disclosed in which the key fragment (VII), obtained from D‐glucose diacetonide, plays a central role serving not only as the source of the C23‐C26 stereocenters but also sets the stage for introducing the C22 stereocenter through regio‐ as well as stereospecific hydroboration oxidation protocol with regard to the exo‐methylenic group in (VII).
ChemInform Abstract: New Perspective in Peptide Chemistry by N‐Alkylation
Authors: Kessler Horst , Chatterjee Jayanta , Doedens Lucas , Operrer Florian , Biron Eric , Hoyer Daniel , Schmid Herbert , Gilon Chaim , Hruby Victor J. , Mierke Dale F. 
Published: March 2011

AbstractReview: 9 refs.
Mai – Ein Prosit auf den Wonnemonat
Authors: Hatscher Deike , Knirsch Sandra 
Published: March 2011

AbstractIm Mai gibt es zahlreiche kulinarische Traditionen wie beispielsweise der Genuss der Maibowle. Dieses auch Maiwein oder Maitrunk genannte Weinmischgetränk fand bereits 854 – vor also über 1150 Jahren – in klösterlichen Schriften als Stärkungsmedizin Erwähnung. Typisch ist die Zubereitung für den Mai, da zu dieser Zeit der Waldmeister, der auch Maikraut genannt wird, am aromaträchtigsten ist.
Examining the Dual Forces of Individual Entrepreneurial Orientation and Liability of Foreignness on International Entrepreneurs
Authors: Joardar Arpita , Wu Sibin 
Published: March 2011

AbstractIn this paper, we adopt a theoretical approach to integrate two streams of literature—that is, entrepreneurship orientation (EO) and liability of foreignness (LOF)—to examine the dual effect of EO and foreignness on international entrepreneurs. First, we argue for the need for developing the constructs of EO and LOF at the individual level (referred to as IEO and ILOF, respectively), as previous research has primarily examined them at the firm level. Then, we develop a 4S framework to characterize entrepreneurs based on their EO and foreignness into four categories—star, survivor, struggler, and slider—and offer predictions on their relative performance. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Fixed bed column adsorption of ACID Yellow 17 dye onto Tamarind Seed Powder
Authors: Patel Himanshu , Vashi R. T. 
Published: April 2011

AbstractThe intention of this study was to explore the efficacy and feasibility for Acid Yellow 17 adsorption onto fixed bed column of Tamarind Seed Powder. The effect of various parameters like flow rate, initial concentration of dye, bed height, and pH were exploited in this study. The Thomas, Yoon–Nelson, Bed Depth Service Time (BDST), and Adams and Bohart model were analysed to evaluate the column adsorption performance. The adsorption capacity, rate constant and correlation coefficient associated to each model for column adsorption was calculated and mentioned. The adsorption capacity increases with increasing initial dye concentration and bed height and decreasing flow rate. The maximum adsorption capacity related to Adams and Bohart model was found to be 978.5 mg/g at initial concentration of 50 ppm at constant flow rate of 15 mL/min, bed height of 15 cm, and pH 7.Le but de cette étude était d'explorer l'efficacité et la faisabilité de l'Acid Yellow 17 adsorption sur colonne à lit fixe de Tamarind Seed Powder. L'effet de différents paramètres comme le débit, la concentration initiale de colorant, la hauteur du lit et le pH ont été exploitées dans cette étude. Le Thomas, Yoon‐Nelson, BDST et Adams et le modèle Bohart ont été analysées pour évaluer les performances d'adsorption colonne. La capacité d'adsorption, constante de vitesse et coefficient de corrélation associé à chaque modèle de la colonne d'adsorption a été calculé et mentionné. Les augmentations de capacité d'adsorption avec une concentration croissante de colorant initial et un lit en hauteur et le débit diminue. La capacité maximale d'adsorption liées au modèle Adams et Bohart a été trouvé à 978,5 mg/g à la concentration initiale de 50 ppm à débit constant de 15 ml/min, la hauteur du lit de 15 cm et un pH de 7.
Coenzyme Q10 Terclatrate and Creatine in Chronic Heart Failure: A Randomized, Placebo‐Controlled, Double‐Blind Study
Authors: Fumagalli Stefano , Fattirolli Francesco , Guarducci Lorenzo , Cellai Tommaso , Baldasseroni Samuele , Tarantini Francesca , Di Bari Mauro , Masotti Giulio , Marchionni Niccolò 
Published: April 2011

AbstractBackground:Studies have suggested that micronutrient deficiency has some role in the progression of chronic heart failure (CHF).Hypothesis:Oral supplementation with coenzyme Q10 (CoQ10) and creatine may reduce mitochondrial dysfunction that contributes to impaired physical performance in CHF.Methods:We conducted a randomized, double‐blind, placebo‐controlled trial to determine the effect of a mixture of water‐soluble CoQ10 (CoQ10 terclatrate; Q‐ter) and creatine on exercise tolerance and health‐related quality of life. Exercise tolerance was measured as total work capacity (kg·m) and peak oxygen consumption (VO2, mL/min/kg), both from a cardiopulmonary exercise test. Health‐related quality of life was measured by the Sickness Impact Profile (SIP) in CHF secondary to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 35%). After baseline assessment, 67 patients with stable CHF were randomized to receive Q‐ter 320 mg + creatine 340 mg (n = 35) or placebo (n = 32) once daily for 8 weeks.Results:At multivariate analysis, 8‐week peak VO2 was significantly higher in the active treatment group than in the placebo group (+1.8 ± 0.9 mL/min/kg, 95% CI: 0.1–3.6, P < 0.05). No untoward effects occurred in either group.Conclusions:This study suggests that oral Q‐ter and creatine, added to conventional drug therapy, exert some beneficial effect on physical performance in stable systolic CHF. Results may support the design of larger studies aimed at assessing the long‐term effects of this treatment on functional status and harder outcomes. © 2011 Wiley Periodicals, Inc.The study was supported by an unconditional grant from Scharper Therapeutics, Milan, Italy, which had the responsibility for manufacturing the active treatment and the placebo. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
LAMP‐2 Gene Expression in Peripheral Leukocytes Is Increased in Patients With Coronary Artery Disease
Authors: Wu Guanghua , Huang Jian , Wei Guanghe , Liu Lixin , Pang Shuchao , Yan Bo 
Published: April 2011

AbstractBackground:Coronary artery disease (CAD) is a common complex disease that is caused by interaction between genetic and environmental factors. Accumulating evidence indicates that foam cells in the atherosclerotic plaques exhibit the characteristics of lysosomal storage diseases, namely lysosomal accumulation of indigested materials. In patients with lysosomal storage diseases, lysosomal accumulation of lipids and cholesterols in atherosclerotic plaque cells has been observed. However, the roles of lysosomal hydrolases and proteins in the pathogenesis of atherosclerosis and CAD remain unclear.Hypothesis:Lysosomal hydrolases and proteins may be involved in the pathogenesis of atherosclerosis and CAD by affecting lipid and cholesterol metabolism.Methods:Expression levels of LAMP‐2, a lysosomal membrane marker gene, in the peripheral leukocytes of CAD patients (n = 134) and age‐ and sex‐matched healthy controls (n = 80) were examined at transcription and protein levels with reverse transcriptase‐polymerase chain reaction and Western blot analyses, respectively. The results were compared between CAD patients and healthy controls.Results:LAMP‐2 gene expression and LAMp‐2 protein levels were significantly increased in the peripheral leukocytes of CAD patients, compared with healthy controls. Furthermore, multivariate logistic regression analyses revealed that CAD is significantly associated with LAMP‐2 gene expression levels (odds ratio [OR] 8.84, 95% confidence interval [CI]: 2.15–36.40, P = 0.003) or LAMP‐2 protein levels (OR 2.03, 95% CI: 1.15–3.59, P = 0.015).Conclusions:In CAD patients, LAMP‐2 gene expression in the peripheral leukocytes was significantly increased than were controls, which indicates lysosomal accumulation. These data suggest that insufficient lysosomal hydrolases and proteins may lead to abnormal lipid and cholesterol metabolism, which cause initiation and progression of atherosclerosis and CAD. © 2011 Wiley Periodicals, Inc.This study was supported by National Science Foundation of China (No. 81070173) and Jining Medical College Affiliated Hospital. The authors have no other funding, financial relationships, or conflicts of interest to disclose.