bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intervertebral disc degeneration and regenerative medicine
Authors: Farag Mariam , Rezk Rogina , Hutchinson Hunter , Zankevich Alina , Lucke‐Wold Brandon 
Published: June 2024

AbstractIntervertebral disc (IVD) degeneration is a common phenomenon that affects patients with increasing prevalence with increasing age. Both conservative treatments, such as the use of pain medication or physical therapy, and surgical treatments, such as fusion or disc replacement therapies, are offered to patients. Both non‐invasive and invasive treatments have been shown to improve pain and quality of life for patients. This review explores the role of regenerative medicine techniques as a promising therapeutic intervention that can be used before or in combination with conservative therapy and surgery to enhance the treatment process in patients with IVD degeneration or disc pathology. Currently, there are four major modules of regenerative medicine: genetic therapy, platelet‐rich plasma therapy, stem cell transplantation and tissue engineering. Several research studies have shown promising outcomes of stem cell transplantation and tissue engineering when combined with either surgical or conservative treatment, resulting in improved pain outcomes. The additional benefit of regenerative medicine techniques, specifically stem cell transplantation, is the potential for treating the root pathology of degeneration. Regenerative medicine techniques also have the potential to either halt or reverse degeneration as opposed to current standards of care for managing symptoms. There is a plethora of current research highlighting the benefits of regenerative medicine techniques; however, there remains clinical concerns and ethical concerns regarding the use of regenerative therapy techniques such as stem cell transplantation in the context of IVD degeneration.
Optofluidic time‐stretch imaging flow cytometry with a real‐time storage rate beyond 5.9 GB/s
Authors: Hou Dan , Zhou Jiehua , Xiao Ruidong , Yang Kaining , Ding Yan , Wang Du , Wu Guoqiang , Lei Cheng 
Published: June 2024

AbstractOptofluidic time‐stretch imaging flow cytometry (OTS‐IFC) provides a suitable solution for high‐precision cell analysis and high‐sensitivity detection of rare cells due to its high‐throughput and continuous image acquisition. However, transferring and storing continuous big data streams remains a challenge. In this study, we designed a high‐speed streaming storage strategy to store OTS‐IFC data in real‐time, overcoming the imbalance between the fast generation speed in the data acquisition and processing subsystem and the comparatively slower storage speed in the transmission and storage subsystem. This strategy, utilizing an asynchronous buffer structure built on the producer‐consumer model, optimizes memory usage for enhanced data throughput and stability. We evaluated the storage performance of the high‐speed streaming storage strategy in ultra‐large‐scale blood cell imaging on a common commercial device. The experimental results show that it can provide a continuous data throughput of up to 5891 MB/s.
Resource allocation strategy of space cloud network based on resource clustering
Authors: Liu Jun , Wang Yufei , Dai Fucheng , Wang Chuang 
Published: June 2024

SummarySpace information network (SIN) is difficult to fully utilize the limited on‐board resource due to its dynamic and heterogeneous nature, while the traditional resource management methods cannot adapt to the increasingly diverse task requirements. Space cloud network architecture is an effective technology to reduce the pressure on satellite resources. To effectively manage the space cloud network resources, we design a resources allocation strategy based on resource clustering. Firstly, we propose the space cloud network architecture. Then, we propose a genetic algorithm to cluster the space cloud resources. Finally, we propose a dynamic resource allocation method based on reinforcement learning for the dynamic characteristics of space cloud resources. The method improves the reinforcement learning algorithm through dynamic objective optimization to complete the optimization of multiple objectives in the process of space cloud resources allocation. The simulation results show that the algorithm proposed in this paper reduces the task execution delay by an average of 10.5% compared with the original DQN algorithm and increases the execution success rate by 2.17%.
Water droplets play a role in Internet of Things applications
Authors: Wen Feng , Lee Chengkuo 
Published: June 2024

AbstractWater droplets help life in nature survive, thrive, and evolve. With water droplet serving as one of the indispensable elements in the Internet of Things (IoT), many droplet‐oriented technologies, such as microfluidics, droplet manipulation, electrowetting, and energy harvesting, make rapid progress driven by material science, computer science, and medicine. Droplet‐based wearable devices are endowed with advantages such as flexibility, sensing ability, and automation for various parameter detection. Besides, the continuous exploration of droplet manipulation has led to the emergence of a wide variety of manipulation methods. Meanwhile, electrowetting that utilizes external fields modifying liquid–solid surfaces has found its applications in various areas, including droplet transportation, microfabrication, and healthcare. The energy generation from water droplets also presents exciting opportunities for the development of novel electricity generators. These approaches for droplet utilization underscore the immense potentials and versatilities of droplet‐based technologies in the IoT landscape. Hence, this mini review presents the fundamental droplet‐based technologies by summarizing their working mechanisms and methods, device structures, and applications. Given the challenges in materials, fabrication, and system integration, this review shows the overall development roadmap in terms of improved functionality and performance and highlights the opportunities toward multifunctional, self‐sustainable, and intelligent systems, which is called for IoT construction.
AC breakdown characteristics of ultra violet curable epoxy resin with nitrogen fine bubbles
Authors: Araoka Nobutaka , Takamura Norimitsu , Inoue Tsubasa , Hanai Masahiro 
Published: June 2024

AbstractWe investigated AC breakdown characteristics of ultra violet curable epoxy resin (UV‐EP) with nitrogen fine bubbles (FBs) in order to improve insulating properties of UV‐EP. As a result, it was found that self‐made FB generator mainly add FBs with a diameter between 60 and 150 nm to FB‐EP before curing. In addition, SEM images revealed that FB‐EP has FBs after curing. Bubble diameter in FB‐EP after curing was estimated between 55 and 140 nm due to resin shrinkage. Furthermore, partial discharge inception voltage and electric strength of FB‐EP with FB addition for 10 min were almost the same as No FB‐EP.
Prognostic utility of cardiopulmonary exercise testing with simultaneous exercise echocardiography in heart failure with preserved ejection fraction
Authors: Naito Ayami , Kagami Kazuki , Yuasa Naoki , Harada Tomonari , Sorimachi Hidemi , Murakami Fumitaka , Saito Yuki , Tani Yuta , Kato Toshimitsu , Wada Naoki , Adachi Takeshi , Ishii Hideki , Obokata Masaru 
Published: June 2024

AbstractAimsCardiopulmonary exercise testing (CPET) combined with exercise echocardiography (CPETecho) allows simultaneous assessments of cardiac, pulmonary, and ventilation in heart failure (HF) with preserved ejection fraction (HFpEF). This study sought to determine whether simultaneous assessment of CPET variables could provide additive predictive value over exercise stress echocardiography in patients with dyspnoea.Methods and resultsCPETecho was performed in 443 patients with suspected HFpEF (240 HFpEF and 203 controls without HF). Patients with HFpEF were divided based on peak oxygen consumption (VO2, ≥10 or <10 ml/min/kg) or the slope of minute ventilation to carbon dioxide production (VE vs. VCO2 slope ≥45.0 or <45.0). The primary endpoint was defined as a composite of all‐cause mortality, HF hospitalization, unplanned hospital visits requiring intravenous diuretics, or intensification of oral diuretics. During a median follow‐up of 399 days, the composite outcome occurred in 57 patients. E/e' ratio during peak exercise was associated with adverse outcomes. Patients with HFpEF and lower peak VO2 had increased risks of the composite event (hazard ratio [HR] 5.05, 95% confidence interval [CI] 2.65–9.62, p < 0.0001 vs. controls; HR 3.14, 95% CI 1.69–5.84, p = 0.0003 vs. HFpEF with higher peak VO2). Elevated VE versus VCO2 slope was also associated with adverse events in HFpEF. The addition of either the presence of abnormal peak VO2 or VE versus VCO2 slope increased the predictive ability over the model based on age, sex, atrial fibrillation, left atrial volume index, and exercise E/e' (p < 0.05).ConclusionThese data provide new insights into the role of CPETecho in patients with HFpEF.
Understanding Gold‐Alkyne Activation from Bond Dissociation Energies of Gold‐Alkyne Complexes
Authors: Gatineau David , Lesage Denis , Guéret Rodolphe , Mador Samuel Danladi , Milet Anne , Gimbert Yves 
Published: June 2024

AbstractA detailed approach into electronic effects of ligands on gold‐alkyne interactions has been carried out in the gas phase using tandem mass spectrometry. A semi‐empirical method coupled to DFT calculations was used to quantify ligands effects on Au−CC bond strength. To this end, the critical energies of 16 [L−Au‐hex‐3‐yne]+ complexes with different L ligands were determined through collision induced dissociation. It was observed that electron‐rich ligands destabilize the gold‐alkyne bond, whereas phosphites and carbenes strengthened it. The influence of alkyne electronic effects on the gold‐alkyne bond has also been studied by dissociation in tandem mass spectrometry on four different alkynes. In an original approach, two successive ion‐molecule reactions within the mass spectrometer were used to measure the relative affinity of gold to an alkyne by exchange reactions. The result is that the more electron‐rich the alkyne, the stronger the gold‐alkyne bond.
The role of graphene and molybdenum disulfide in rechargeable energy storage systems: Perspective and challenges
Authors: A Preethi , S Dawnee , T D Senthilkumar , Atla Rushita 
Published: June 2024

AbstractTo offset the intermittent nature, renewable energy sources must be paired with energy storage systems (ESS) to cater to the demand for clean energy solutions. The performance characteristics requirements of these ESS are application‐specific, say batteries are characterized by their high energy capacity while supercapacitors offer greater power density. Currently, the research concentration in this domain is on improving the performance parameters of proven energy storage chemistries. Two‐dimensional (2D) materials characterized by high specific surface area, and tunable physical and electrical properties are explored extensively to enhance ESS performance. This review comprehends the progress made by two typical 2D materials, Graphene and Molybdenum disulfide, to enhance the energy/ power capacity, and life span of a few chosen rechargeable storage chemistries, lithium‐ion, lithium‐sulfur batteries, supercapacitors, and flow batteries. Further the review presents the current state of ESS, the challenges identified so far which restrict their capacity and life span, and the solutions employed to date. Finally, the challenges associated with these solutions are critically analyzed to suggest future directions and research perspectives in this domain.
Development of a plant‐based surgical training model for fluorescence‐guided cancer surgery
Authors: Shigeyama Mayu , Nishio Naoki , Wada Akihisa , Mitani Sohei , Morimoto Gaku , Yokoi Sayaka , Mukoyama Nobuaki , Yokoi Mai , van Keulen Stan , Rosenthal Eben , Sone Michihiko 
Published: June 2024

AbstractBackgroundFluorescence‐guided surgery (FGS) can help surgeons to discriminate tumor tissue from adjacent normal tissues using fluorescent tracers.MethodsWe developed a surgical training model, manufactured using sustainable vegetable organic material with indocyanine green (ICG)‐containing “tumor.” Surgeons evaluated the model with both the closed‐field and endoscopic fluorescence imaging devices and assessed its efficacy to identify residual tumor after enucleation using electrocautery.ResultsStrong correlations of fluorescence were obtained at all working distance (3, 5, 7, and 10 cm), showing the robustness of fluorescence signal for the closed‐field and endoscopic fluorescence imaging devices. The higher fluorescence signals were obtained in the wound bed in the closed‐field fluorescence imaging device and the residual tumor could be clearly identified by fluorescence endoscopy.ConclusionsOur FGS training model may provide experience for surgeons unfamiliar with optical surgery and subsequent tissue interactions. The model seemed particularly helpful in teaching surgeons the principles of FGS.
Meeting new expertise needs throughout careers: A group model building approach in the field of HR/D
Authors: Frie Lonneke S. , Korzilius Hubert P. L. M. , Dobbinga Sjoerd , Van der Heijden Beatrice I. J. M. , Sjoer Ellen 
Published: June 2024

AbstractOrganizational and societal transitions require workers to upskill and reskill their expertise within and across the boundaries of their current domain(s). This may also require them to materialize their renewed expertise in novel settings in interaction with stakeholders who hold different expectations regarding their know‐how and contributions. To stay employable, workers need to deal with shifting expertise needs by creating beneficial outcomes for themselves and their stakeholders, as captured by the so‐called flexpertise concept. Thus far, expertise research left largely unaddressed how workers adapt through intra‐individual changes over time and social interactions in naturalistic settings in which they encounter various new expertise needs. To increase our understanding of the dynamic nature of workers' adaptation processes, we conducted a Group Model Building study with HR/D practitioners. Through this structured group facilitation method, these practitioners cocreated a dynamic process model, based upon their varied experiences in practice regarding the flexpertise phenomenon. The newly developed model portrays how workers make balanced decisions to adapt, go through loops of learning‐by‐mistakes and ‐successes, and ultimately turn their new know‐how into outcomes, with or without impact, leading to new adaptation cycles. Furthermore, the practitioners defined leverage points where HR/D practices can stimulate individual adaptivity. This GMB study may set the agenda for future expertise and employability research and provides the foundation for designing bundles of HR/D practices to foster flexpertise.
Is temporary clamping of the bilateral common iliac artery beneficial in reducing intraoperative blood loss in patients with segmental resected anterior placenta percreta?: A prospective observational study
Authors: Özcan Hüseyin Çağlayan , Barut Mustafa Baturalp , Sucu Seyhun , Bademkiran Muhammed Hanifi , Tepe Neslihan Bayramoğlu , Özcan Zeynep Özer , Kazaz Tanyeli Güneyligil 
Published: June 2024

AbstractObjectiveThe aim of our study was to investigate whether temporary clamping of the bilateral common iliac artery (BCIA) has a role in reducing intraoperative blood loss in patients with segmentally resected anterior placenta percreta or not.MethodsThis prospective observational study included patients with anterior placenta percreta who underwent cesarean segmental resection either with BCIA temporary clamping or without clamping between October 2022 and September 2023.ResultsA comparison of demographic, obstetric, and surgical parameters and the need for transfusion (except for postoperative erythrocyte suspension transfusion) between the two groups revealed no significant difference (P > 0.05). In contrast, the amount of intraoperative blood loss (P = 0.001) (1974 ± 749 mL vs 2702 ± 615 mL) and postoperative erythrocyte suspension transfusion (P = 0.046) in patients who underwent BCIA temporary clamping were significantly lower than in those who did not undergo BCIA temporary clamping.ConclusionTemporary clamping of BCIA plays a significant favorable role both in reducing blood loss and the need for postoperative transfusion in patients with placenta percreta who underwent segmental uterine resection.
Heterotopic twin pregnancy in unicornuate uterus and non‐communicating rudimentary horn with survival of both fetuses: Magnetic resonance imaging and 3D reconstructions findings
Authors: Elito Júnior Julio , Goldman Suzan Menasce , Castro Pedro Teixeira , Werner Heron , Sanchez Victor Hugo Saucedo , Araujo Júnior Edward 
Published: June 2024

AbstractWe reported a case of heterotopic twin pregnancy in a unicornuate uterus with a non‐communicating rudimentary horn with survival of both fetuses. The diagnosis was made late at 28 weeks of gestation, with suspicion raised by ultrasound and confirmed by magnetic resonance imaging (MRI). During hospitalization, obstetric ultrasound with color Doppler was performed every 2 days to assess fetal well‐being and myometrial thickness, which was determined by measurements of the uterine wall at the accessory horn. Elective cesarean section was performed at 33 + 5 weeks of gestation. Delivery started with the fetus in the rudimentary horn, with subsequent extraction of the fetus in the unicornate uterus. Three‐dimensional virtual reconstruction allowed a spatial view of the both uterus and fetuses with better understanding of the obstetrical condition by the parents and interactive discussion by the multidisciplinary medical team.
Analyzing noncovalent interactions between notoginseng saponins and lysozyme by deposition scanning intensity fading MALDI‐TOF mass spectrometry
Authors: Zhao Xintong , Ren Juan , Wang Ze , Chen Xiangfeng 
Published: June 2024

AbstractAnalysis of noncovalent interactions between natural products and proteins is important for rapid screening of active ingredients and understanding their pharmacological activities. In this work, the intensity fading MALDI‐TOF mass spectrometry (IF‐MALDI‐MS) method with improved reproducibility was implemented to investigate the binding interactions between saponins from Panax notoginseng and lysozyme. The benchmark IF‐MALDI‐MS experiment was established using N,N′,N″‐triacetylchitotriose‐lysozyme as a model system. The reproducibility of ion intensities in IF‐MALDI‐MS was improved by scanning the whole sample deposition with a focused laser beam. The relative standard deviation (RSD) of deposition scanning IF‐MALDI‐MS is 5.7%. Similar decay trends of the relative intensities of notoginseng saponins against increasing amounts of lysozyme were observed for all six notoginseng saponins. The half‐maximal fading concentration (FC50) was calculated to quantitatively characterize the binding affinity of each ligand based on the decay curve. According to the FC50 values obtained, the binding affinities of the six notoginseng saponins were evaluated in the following order: notoginsenoside S > notoginsenoside Fc > ginsenoside Rb1 > ginsenoside Rd > notoginsenoside Ft1 > ginsenoside Rg1. The binding order was in accordance with molecular docking studies, which showed hydrogen bonding might play a key role in stabilizing the binding interaction. Our results demonstrated that deposition scanning IF‐MALDI‐MS can provide valuable information on the noncovalent interactions between ligands and proteins.
Numerical assessment of changes in land–atmosphere interactions during the rainy season in South America using an updated vegetation map
Authors: Talamoni Isabella L. , Kubota Paulo Y. , Cavalcanti Iracema F. A. , de Souza Dayana C. , Baker Jessica C. A. , Vieira Rita M. S. P. 
Published: June 2024

AbstractLand Use and Land Cover Change (LULCC) is a key driver of changes in land–atmosphere interactions, playing an essential role in climate and weather patterns in South America (SA). This study used a modelling approach to assess the land–atmosphere changes introduced by LULCC over the Brazilian territory. Numerical experiments of early (2006), neutral (2004) and late (2008) rainy season onset years were performed in the Integrated BIosphere Simulator (IBIS) to assess the land‐surface parameters, and in Brazilian Atmospheric Model (BAM) to assess the atmospheric variables. The models were run with a natural (NAT) vegetation map and an updated (UP) vegetation map, which incorporated realistic Brazil deforestation up to the early 2000s. The differences between the two maps were particularly larger over 25°–15°S and 50°–40°W, where the Atlantic Forest and Cerrado biomes were replaced by pasture. IBIS experiments showed that over the area of larger LULCC there was an increase in albedo of up to 8% while reductions in net radiation, surface heat fluxes, surface temperature and surface roughness were noticed. Land–atmosphere feedbacks assessed with BAM experiments showed that LULCC contributed to a drier and colder (stable) atmosphere over central‐east SA that opposes the necessary conditions for the rainy season onset. The changes included increases in surface pressure and low‐level wind associated with reductions in 2 m temperature and surface roughness. These changes contributed to decrease the cloud formation and less precipitation in all three rainy season onset years, but particularly in the late rainy season onset year during September–October–November (SON). The atmospheric changes induced by LULCC show a pattern of dry atmosphere (reduced precipitation), similar to those of late onset years, and indicate that LULCC enhances the late rainy season onset condition over central‐east SA. Additionally, this study highlights the importance of considering up‐to‐date vegetation maps because these changes significantly affect both surface and atmospheric variables.
Robot‐assisted transanal minimally invasive surgery for the treatment of rectal adenocarcinoma
Authors: Araujo Sérgio Eduardo Alonso , Seid Victor Edmond , Portilho Ana Sarah , Horcel Lucas de Araujo , Tustumi Francisco 
Published: June 2024

AbstractThis is a video vignette of a 57‐year‐old asymptomatic female patient. The patient underwent a screening colonoscopy which revealed a 10 mm scar in the rectum. Biopsy resulted in a well‐differentiated tubular adenocarcinoma. Computed tomography and pelvic magnetic resonance imaging confirmed tumor characteristics without distant or lymph nodal metastasis. A minimally invasive robotic transanal resection using the Da Vinci Xi platform was performed, achieving full‐thickness lesion excision with uneventful recovery. Histopathology revealed intramucosal adenocarcinoma with free margins. Local resection is advocated for selected T1 lesions and demands a thorough preoperative assessment. Robotic‐assisted surgery presents a valuable alternative for early rectal adenocarcinoma management.