bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les soins aux enfants et aux adolescents ayant la paralysie cérébrale (aux niveaux III à V du GMFCS)
Authors: McLeod Scott , Makino Amber , Kawamura Anne 
Published: May 2024

Résumé
La paralysie cérébrale (PC) est l’incapacité physique la plus fréquente chez les enfants canadiens. Les soins complets des enfants ayant la PC, qui sont capables de marcher et qui fonctionnent aux niveaux I et II du système de classification de la fonction motrice globale (GMFCS) sont déjà exposés dans un point de pratique. Le présent document complémentaire traite des soins aux enfants ayant la PC qui fonctionnent aux niveaux III à V du GMFCS. Ceux qui fonctionnent aux niveaux III et IV du GMFCS utilisent des dispositifs d’assistance comme des déambulateurs, des cannes ou des aides à la mobilité motorisées, tandis que ceux qui fonctionnent au niveau V du GMFCS ont besoin d’assistance à la mobilité comme un fauteuil roulant manuel. Le présent document contient un aperçu des principaux concepts relatifs à la détection précoce, aux services de réadaptation et aux possibilités de traitement pour les enfants présentant ces niveaux de PC, conjointement avec des ressources pratiques pour contribuer à la surveillance de la santé assurée par les pédiatres qui s’occupent de cette population.
Umbilical cord blood-derived therapy for preterm lung injury: a systematic review and meta-analysis
Authors: Purcell Elisha , Shah Jainam , Powell Cameron , Nguyen Timothy , Zhou Lindsay , McDonald Courtney A , Allison Beth J , Malhotra Atul 
Published: May 2024

Abstract

Introduction
Lung injuries, such as bronchopulmonary dysplasia (BPD), remain a major complication of preterm birth, with limited therapeutic options. One potential emerging therapy is umbilical cord blood (UCB)-derived therapy.

Objectives
To systematically assess the safety and efficacy of UCB-derived therapy for preterm lung injury in preclinical and clinical studies.

Methods
A systematic search of MEDLINE, Embase, CENTRAL, ClinicalTrials.gov, and WHO International Trials Registry Platform was performed. A meta-analysis was conducted with Review Manager (5.4.1) using a random effects model. Data was expressed as standardized mean difference (SMD) for preclinical data and pooled relative risk (RR) for clinical data, with 95% confidence intervals (CI). Potential effect modifiers were investigated via subgroup analysis. Certainty of evidence was assessed using the GRADE system.

Results
Twenty-three preclinical studies and six clinical studies met eligibility criteria. Statistically significant improvements were seen across several preclinical outcomes, including alveolarization (SMD, 1.32, 95%CI [0.99, 1.65]), angiogenesis (SMD, 1.53, 95%CI [0.87, 2.18]), and anti-inflammatory cytokines (SMD, 1.68, 95%CI [1.03, 2.34]). In clinical studies, 103 preterm infants have received UCB-derived therapy for preterm lung injury and no significant difference was observed in the development of BPD (RR, 0.93, 95%CI [0.73, 1.18]). Across both preclinical and clinical studies, administration of UCB-derived therapy appeared safe. Certainty of evidence was assessed as “low.”

Conclusions
Administration of UCB-derived therapy was associated with statistically significant improvements across several lung injury markers in preclinical studies. Early clinical studies demonstrated the administration of UCB-derived therapy as safe and feasible but lacked data regarding efficacy.
Characterization of Lumbar Lordosis
Authors: Baumann Charles A. , Pazooki Parsa , McNamara Kyle P. , Jeffs Alexander D. , Perlewitz Madeline A. , Visco Zachary R. , Scott Stephen M. , Lim Moe R. , Weinberg Douglas S. 
Published: May 2024

Study Design:
Retrospective radiographic review.

Objective:
The objectives of the study were to determine the contributions to lumbar lordosis (LL) through both the vertebrae and the intervertebral disc (IVD), and to investigate the relationships between lumbar sagittal spine measurements and age and gender.

Summary of Background Data:
A small body of literature exists on the relative contributions of vertebral body and IVD morphology to LL, the effects of L4-S1 on overall LL, and the relationships/correlations between lumbar sagittal spine measurements.

Methods:
Patients who met the inclusion criteria were retrospectively evaluated. Measurements included LL, pelvic incidence (PI), and % contributions of vertebral body wedging/IVD wedging/L4-S1 to LL. Patients were separated into groups by age and sex, demographic data were collected, and statistical analysis was completed.

Results:
LL decreased with age, although PI remained similar. Females demonstrated increased LL and vertebral body wedging % than males. Males demonstrated increased L4-S1% than females. Despite a decrease in LL with age, patients maintained L4-S1% and IVD wedging %. There was a significant negative relationship between PI and IVD wedging, PI and L4-S1%, and LL and L4-S1%.

Conclusions:
During aging, the lumbar spine loses LL linearly. This occurs in the IVD and vertebral bodies. Females have increased LL compared with males, because of an increase in vertebral body wedging and IVD/vertebral wedging cranial to L4. In patients with high PI or LL, increased LL occurs from cranial to L4 and from vertebral body wedging.
Development and Validation of a Prediction Model for 1-Year Mortality in Patients With a Hematologic Malignancy Admitted to the ICU
Authors: Boldingh Jan-Willem H.L. , Arbous M. Sesmu , Biemond Bart J. , Blijlevens Nicole M.A. , van Bommel Jasper , Hilkens Murielle G.E.C. , Kusadasi Nuray , Muller Marcella C.A. , de Vries Vera A. , Steyerberg Ewout W. , van den Bergh Walter M. ,   on behalf of the Hematologic Malignancy Admitted on the ICU (HEMA-ICU) Study Group
Published: May 2024

OBJECTIVES:
To develop and validate a prediction model for 1-year mortality in patients with a hematologic malignancy acutely admitted to the ICU.

DESIGN:
A retrospective cohort study.

SETTING:
Five university hospitals in the Netherlands between 2002 and 2015.

PATIENTS:
A total of 1097 consecutive patients with a hematologic malignancy were acutely admitted to the ICU for at least 24 h.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
We created a 13-variable model from 22 potential predictors. Key predictors included active disease, age, previous hematopoietic stem cell transplantation, mechanical ventilation, lowest platelet count, acute kidney injury, maximum heart rate, and type of malignancy. A bootstrap procedure reduced overfitting and improved the model’s generalizability. This involved estimating the optimism in the initial model and shrinking the regression coefficients accordingly in the final model. We assessed performance using internal–external cross-validation by center and compared it with the Acute Physiology and Chronic Health Evaluation II model. Additionally, we evaluated clinical usefulness through decision curve analysis. The overall 1-year mortality rate observed in the study was 62% (95% CI, 59–65). Our 13-variable prediction model demonstrated acceptable calibration and discrimination at internal–external validation across centers (C-statistic 0.70; 95% CI, 0.63–0.77), outperforming the Acute Physiology and Chronic Health Evaluation II model (C-statistic 0.61; 95% CI, 0.57–0.65). Decision curve analysis indicated overall net benefit within a clinically relevant threshold probability range of 60–100% predicted 1-year mortality.

CONCLUSIONS:
Our newly developed 13-variable prediction model predicts 1-year mortality in hematologic malignancy patients admitted to the ICU more accurately than the Acute Physiology and Chronic Health Evaluation II model. This model may aid in shared decision-making regarding the continuation of ICU care and end-of-life considerations.
Gut microbiota metabolites and risk of major adverse cardiovascular events and death: A systematic review and meta-analysis
Authors: Khan Qaisar Ali , Asad Muhammad , Ali Abdul Hannan , Farrukh Ameer Mustafa , Naseem Usama , Semakieh Bader , Levin Carrion Yaxel , Afzal Muhammad 
Published: May 2024

Background:
Gut microbial metabolites such as trimethylamine N-oxide (TMAO) and its precursors, namely betaine, L-carnitine, and choline, have been implicated as risk factors for cardiovascular events and mortality development. Therefore, we aim to perform a systematic review and meta-analysis to assess the validity of these associations.

Methods:
MEDLINE and Scopus were queried from their inception to August 2023 to identify studies that quantified estimates of the associations of TMAO with the development of major adverse cardiovascular events (MACE) or death. A random-effects meta-analysis was conducted to pool unadjusted or multivariable-adjusted hazard ratios (HR) and their 95% confidence intervals. The primary endpoint was the risk of MACE and all-cause death.

Results:
30 prospective observational studies (n = 48 968) were included in the analysis. Elevated TMAO levels were associated with a significantly greater risk of MACE and all-cause death compared to low TMAO levels (HR: 1.41, 95% CI 1.2–1.54, P < .00001, I
2 = 43%) and (HR: 1.55, 95% CI 1.37–1.75, P < .00001, I
2 = 46%), respectively. Furthermore, high levels of either L-carnitine or choline were found to significantly increase the risk of MACE. However, no significant difference was seen in MACE in either high or low levels of betaine.

Conclusion:
Elevated concentrations of TMAO were associated with increased risks of MACE and all-cause mortality. High levels of L-carnitine/choline were also significantly associated with an increased risk of MACE. However, no significant difference was found between high or low levels of betaine for the outcome of MACE.
The efficacy and safety of ginger (Zingiber officinale) rhizome extract in outpatients with COVID-19: A randomized double-blind placebo-control clinical trial
Authors: Ameri Ali , Farashahinejad Mehdi , Davoodian Parivash , Safa Omid , Hassaniazad Mehdi , Parsaii Mohsen , Heidari Behnoosh , Hassanipour Soheil , Akhlaghi Boshra , Fathalipour Mohammad 
Published: May 2024

Background:
Ginger, a potent antiviral, anti-inflammatory, and antioxidant remedy, is a potential therapeutic option for COVID-19. However, there was not enough clinical evidence about ginger and COVID-19. We evaluated the efficacy and safety of ginger on clinical and paraclinical features in outpatients with COVID-19.

Methods:
In this randomized controlled trial, the outpatients with confirmed COVID-19 were randomly assigned in a 1:1 ratio to receive ginger (1000 mg 3 times a day for 7 days) or placebo. The primary outcome was viral clearance after the end of the intervention. Oxygen saturation (SPO2), body temperature, respiratory rate (RR), hospital admission, and the incidence of adverse events were also assessed.

Results:
A total of 84 patients (42 in the ginger and 42 in the control groups) were randomized. The viral clearance was not statistically improved in the ginger group (41.6%) compared to the placebo group (42.8%). The findings indicated that SPO2, body temperature, and RR had no significant difference between the groups at the end of the intervention. The imaging finding indicated pulmonary infiltrate significantly reduced on the 7th day of the intervention in the ginger group. The percentage of patients with SPO2 <96% in the ginger group decreased over the study compared to the placebo group. Moreover, the need for hospital admission and the incidence of adverse drug events were not different between the groups over the follow-up period.

Conclusions:
Ginger had no significant impact on the clinical and paraclinical parameters of patients. However, this intervention demonstrated a safe profile of adverse events and reduced pulmonary infiltrate.

Trial registration:
The trial was registered as IRCT20200506047323N1.
Snare device retrieval of occluder embolized in patent foramen ovale closure: A case report
Authors: Hou Huijuan , Zhang Qiang , Dong Hongwei 
Published: May 2024

Rationale:
Transcatheter interventional closure therapy is the main treatment method for patent foramen ovale (PFO). However, occluder abscission is a serious complication in PFO interventional therapy. Thus, timely and effective management of the occluder detachment is crucial for improving patient prognosis.

Patient concerns:
A 52-year-old female patient was admitted to the Department of Neurology mainly due to “right upper limb weakness for two days, which aggravated for eight hours.” The patient had no history of any other diseases.

Diagnoses:
The patient was diagnosed with an atrial septal defect (foramen ovale type) and cerebral infarction.

Interventions and outcomes:
The occluder abscission was successfully removed after several attempts with the help of the snare device.

Lessons:
When the PFO occlusion device is detached, interventional treatment would lead to minimal trauma, fast postoperative recovery, and a definite therapeutic effect. Based on mastering the indications and standardizing the operational process, this is a safe and effective minimally invasive treatment method.
Efficacy of hydrodistension for frozen shoulder: A systematic review and meta-analysis
Authors: Chen Tianpeng , Li Wei , Zhong Yong , Chen Tianle , Shi Xiaolin 
Published: May 2024

Background:
The aim of this study was to provide comprehensive and reliable evidence for the treatment of pain and motor function in patients with frozen shoulder (FS) with hydrodistension

Methods:
The research including randomized controlled trials (RCTs) for FS that compared hydrodistension with routine treatments to controls was searched and screened in the PubMed, Library of congress, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, China Science and Technology Journal Database. Constant-Murley score (CMS) for shoulder function and visual analog scale (VAS) for pain must be assessed. RevMan 5.3 software was used to evaluate the bias and quality of the included studies.

Results:
We found that analgesic effects (MD: −1.07; 95% CI: −1.94 to −0.20; P < .00001; I
2 = 99%) and function (MD: 8.54; 95% CI: 3.35 to 13.71; P < .00001; I
2 = 97%) were better in the groups where hydrodistension plus routine treatments were used to treat FS compared to other interventions.

Conclusion:
The result suggests that hydrodistension is of great clinical significance in alleviating pain and improving function to patients with FS.
Navigating the future: machine learning's role in revolutionizing antimicrobial stewardship and infection prevention and control
Authors: Hanna John J. , Medford Richard J. 
Published: May 2024

Purpose of review
This review examines the current state and future prospects of machine learning (ML) in infection prevention and control (IPC) and antimicrobial stewardship (ASP), highlighting its potential to transform healthcare practices by enhancing the precision, efficiency, and effectiveness of interventions against infections and antimicrobial resistance.

Recent findings
ML has shown promise in improving surveillance and detection of infections, predicting infection risk, and optimizing antimicrobial use through the development of predictive analytics, natural language processing, and personalized medicine approaches. However, challenges remain, including issues related to data quality, model interpretability, ethical considerations, and integration into clinical workflows.

Summary
Despite these challenges, the future of ML in IPC and ASP is promising, with interdisciplinary collaboration identified as a key factor in overcoming existing barriers. ML's role in advancing personalized medicine, real-time disease monitoring, and effective IPC and ASP strategies signifies a pivotal shift towards safer, more efficient healthcare environments and improved patient care in the face of global antimicrobial resistance challenges.
How do I deal with complex social commerce landscape? Understanding continuance intention using approach and avoidance motivations model
Authors: Chong Sin-Er , Ng Siew-Imm , Kamal Basha Norazlyn Binti , Lim Xin-Jean 
Published: May 2024

PurposeIn the vibrant world of social commerce (SC), where information flows freely, interactions thrive and online purchases abound, there is an escalating challenge. Users are uninstalling and disengaging due to approach and avoidance stimuli, a trend mirroring the approach-avoidance motivation model (AAMM). Our study, anchored in AAMM and the stimulus-organism-response (SOR) model, aims to dive into the complex dynamics of these factors that shape users' SC continuance intentions.Design/methodology/approachOur findings, drawn from 472 SC users in Malaysia, paint an intriguing research framework via PLS-SEM analysis by testing the proposed hypotheses. A purposive sampling technique was utilized, deliberately selecting respondents based on specific criteria. Subsequently, data were gathered through the distribution of face-to-face questionnaires at selected shopping malls, facilitating a focused and comprehensive exploration of consumer perspectives.FindingsThe empirical results demonstrate the following: (1) Users' determination to stay engaged on SC platforms hinges on approach factors, like emotional support, surveillance gratification and multisensory gratification. (2) Simultaneously, avoidance factors such as technostress and perceived deception exert their negative influence. (3) Flow experience, rooted in flow theory, emerges as the underlying mechanism connecting these duality stimuli, influencing the continuance intention.Originality/valueIn a departure from conventional research, our study pioneers a comprehensive approach and boldly confronts the research gap by introducing a rich tapestry of antecedents, embracing both the appeal of approach factors and the deterrence of avoidance ones, using the AAMM that sheds light on how individuals navigate between embracing opportunities and avoiding pitfalls based on perceived gains and losses. This holistic approach enables us to redefine our understanding of digital engagement dynamics, offering a captivating journey into the realm of user experience and intention that transcends the ordinary.
From the final frontier to the metaverse: exploring the role of sharing economy principles in revolutionizing space tourism
Authors: Beheshti Moein , Mladenović Dušan , Sadraei Razieh , ZareRavasan Ahad 
Published: May 2024

Purpose
As exponential technologies continue to transform business models rapidly, there is a growing focus on metaverse research within the tourism industry. Despite the significant findings, the practical discussion of high-cost and resource-demanding space tourism within the metaverse platform is still abstract. This study aims to provide a comprehensive understanding of virtual space tourism and consumer motivations inspired by the intrinsic principles of the sharing economy business model and the metaverse platforms.

Design/methodology/approach
By gathering primary data through questionnaires from individuals interested in virtual space tourism and using the 530 valid responses, this study uses the unified theory of acceptance and use of technology 2 (UTAUT2) along with the status quo bias theory (SQB) to better comprehend travelers’ motivations for engaging with the metaverse in space tourism.

Findings
The study confirms UTAUT2’s effectiveness in predicting travelers’ adoption behavior. Specifically, factors such as performance expectancy, effort expectancy, social influence, hedonic motivation, price value and facilitating conditions significantly impact attitudes and behavioral intentions toward adopting the metaverse for space tourism. Furthermore, skepticism significantly moderates the relationship between attitudes and behavioral intentions.

Originality/value
This study is one of the first to empirically explore the motivations for using metaverse capabilities in the context of space tourism. In line with recent calls for more research on advancing UN sustainable development goals through the metaverse platform, this research discusses findings based on eight shared attributes in both sharing economies and the metaverse platforms that offer the potential for sustainable, socialized and affordable access to space tourism. In addition to the managerial implications, this study outlines future research directions, drawing on insights from the sharing economy’s success in the tourism industry.
To save the environment is my moral duty: investigating young consumer’s green purchase behaviour with moderated mediation approach
Authors: Kumar Rakesh 
Published: May 2024

Purpose
The purpose of this study is to investigate the role of ethical obligation and environmental concern in young consumers’ green purchase behaviour using Ajzen’s (1991) theory of planned behaviour as underpinning theoretical model.

Design/methodology/approach
Data collected from 253 college students of a major higher education institution in Northern India were analysed by using structural equation modelling and moderated mediation analysis in AMOS 22.0 and SPSS 20.0.

Findings
Investigating why environmental concern does not significantly translate into green purchase intention, the study demonstrates that the effect of environmental concern was mediated through attitude and ethical obligation. In addition, the study also found that the effect of environmental concern on attitude was positively moderated by ethical obligation. Moreover, subjective norms were found to exhibit no direct effect on green purchase intention; rather, this effect was indirect and mediated through attitude and perceived behavioural control. The results of moderated mediation analysis further demonstrated that the indirect effect of subjective norms on green purchase intention through attitude was found conditional on the values of perceived behavioural control.

Originality/value
The study offers a valuable contribution by signifying the moderating role of ethical obligation in green purchase behaviour. It also contributes to the existing knowledge by assessing the conditional indirect effect of subjective norms on green purchase intention which is rarely examined in the literature.
Rethinking digital finance and information and communication technology (ICT) capital impacts on environmental goods trade under carbon neutrality targets
Authors: Kuang Zheng Yang , Liang Qi , Yu Feng , Hu Wenxiu , Hordofa Tolassa Temesgen , Mughal Nafeesa 
Published: May 2024

AbstractDigital financial inclusion (DFI) is creating dynamics in trade credit financing and trading environmentally through rapid growth of information and communication technology (ICT). Conversely, the empirical evidence is not available to validate the contribution of ICT and DFI in promoting trade in environmental goods. Hence, this research work is an attempt to unfold the nexuses of trade in environmental goods, DFI, and ICT globally in Asia, America, and Europe, respectively. The findings infer that DFI and ICT are the primary factors boosting trade in environmental goods globally, in Asia, America, and Europe, respectively. Furthermore, environmental pollution, economic development, and education are also uplifting the trading related to environmental goods in most regions. In the light of empirical estimates, it suggests that policymakers should give ICT infrastructure and digital connectivity priority investments to maintain the accessibility and effectiveness of environmental goods trading.