bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of composites with nanoscale silicon and silicate oxides with lithium using three-dimensionally driven ball mill
Authors: Shimoi Norihiro , Aonuma Hirotaka , Komatsu Masae 
Published: June 2024

Abstract

To achieve high-performance electrochemical anodes properties, active materials of anodes with improved cycle performance were composited using Cu alloys, silicon oxides and Li compounds within a composite by a simple mechanochemical milling process. The three-dimensionally driven ball mill used as a mechanochemical apparatus in this study can independently control two axes and can perform combined milling and frictional movements realized by adjusting the rotational speed of the vessel. The composite consisting of silicon, lithium oxide and copper oxide using these movements has Si nanoparticles, amorphous silicon monoxide, and Si–Cu alloy compounds, and a layer of silicon oxide on its surface. The prepared composite achieved higher retention capacity, higher coulomb efficiencies of approximately 90% and longer-cycle performance than Si particles, indicating a considerable optimisation of electrical and ionic conductivities in the composite. As a result, the method developed enabled the control of Li content to compensate for the lack of Li ions in the composite and optimised cycle performance with Cu alloys, oxides and Li compounds in the composite.
Mechanistic insights into antifungal potential of Alexidine dihydrochloride and Hexachlorophene in Candida albicans: A Drug repurposing approach
Authors: Ansari Ayesha , Kumar Darshan , Gupta Payal , Poluri Krishna Mohan , Rai Nishant , Ameen Faud , Kumar Navin 
Published: June 2024

Abstract

Candida albicans has been listed in critical priority group by the WHO in 2022 depending upon its contribution in invasive candidiasis and increased resistance to conventional drugs. Drug repurposing is an efficient and cost-effective solution to develop alternative therapeutics where alexidine dihydrochloride (AXD) and hexachlorophene (HCP) are FDA approved anti-cancer and anti-septic drugs, respectively. In this study, we have shown antifungal properties of AXD and HCP against C. albicans and clinical isolates. The minimum inhibitory concentrations (MIC50) of AXD and HCP against C. albicans ranged between 0.2-0.4 µg/ml and 8-10 µg/ml, respectively. The biofilm inhibitory and eradication concentration of AXD and HCP also ranged in permissible range for C. albicans biofilm. Further investigations were performed to understand the antifungal mode of action of AXD and HCP by studying virulence features like cell surface hydrophobicity, adhesion, and yeast to hyphae transition, were also reduced upon exposure to both the drugs. Ergosterol content in cell membrane of the wild type strain was upregulated on exposure to AXD and HCP both. Biochemical analyses of the exposed biofilm indicated reduced contents of carbohydrate, protein, and e-DNA in the extracellular matrix of the biofilm when compared to the untreated control biofilm. AXD exposure downregulated activity of tissue invading enzyme, phospholipase in the reference strain. In wild type strain, ROS level, and activities of antioxidant enzymes were found elevated upon exposure to both drugs. FESEM analysis of the drug treated biofilms revealed degraded biofilm. This study has indicated mode of action of antifungal potential of alexidine dihydrochloride and hexachlorophene in C. albicans.
Whipple's disease with early central nervous system damage: a case report
Authors: Meng Xuefang , Liang Qian , Wei Yingxiu , Wei Xiaorong , Wei Yanping , Li Qijun 
Published: June 2024

Abstract

Background: Whipple's disease (WD) is a rare, complex, multisystemic infection caused by Trophoryma whipplei (TW). Clinical diagnosis is challenging because of the low incidence rate, diversity of clinical manifestations, and lack of specificity in imaging examinations and routine laboratory tests.
Case presentation: We report a case of early central nervous system involvement in a patient with obesity and type II diabetes. After three days of fever and coughing, the patient’s condition aggravated with convulsive seizures and coma. Chest CT tomography revealed pulmonary inflammation, and brain Magnetic Resonance Imaging (MRI) were normal. The concentrations of chloride and sugar in the cerebrospinal fluid (CSF) were normal. The amount of cellular components was not significantly increased, but the protein level was slightly elevated. TW in bronchoalveolar lavage samples was confirmed using metagenomics next-generation sequencing (mNGS) after three weeks of meropenem combined with doxycycline and hormone treatment, and the patient’s symptoms were completely alleviated.
Conclusions: This case indicates that certain WD patients have early impairment of the central nervous system. If clinicians are aware of the presence of rare pathogenic bacterial infections and immediately apply mNGS for the early identification and treatment with targeted antibiotics, it can improve the prognosis of patients with WD.
Social pain and physical pain: a cohort study to explore the association of social isolation and loneliness with chronic pain among older adults in China
Authors: Han Xinru , Qiao Yiwei , Tan Jialong , Luo Zhi , Nicholas Stephen , Maitland Elizabeth , Han Lu , Xu Zhihao , Wang Jian 
Published: June 2024

Abstract

Background Accelerated by population aging, social isolation and loneliness have correlated significantly with the health of older adults. This study investigates the association of social isolation and loneliness on the prevalence of chronic pain among Chinese older adults.
Methods Participants from waves of the Chinese Health and Retirement Longitudinal Study (CHARLS) with no chronic pain in baseline 2011, and their conditions of chronic pain in wave 2018, were analyzed. The exposure factors were social isolation and loneliness. Social isolation was assessed by a comprehensive multi-factor measure, while loneliness and the outcome variable, chronic pain, were self-reported. The association of the exposure factors on the prevalence of chronic pain was conducted by logistic regression.
Results 2,477 older adults who did not suffer from chronic pain at baseline 2011 were enrolled, of whom 1,335 participants (53.90%) developed chronic pain over a span of seven years. The results showed that social isolation (OR:1.19, 95%CI: 1.01 to 1.41) and loneliness (OR:1.53, 95%CI: 1.26 to 1.87) were associated with an elevated risk of chronic pain over seven years. It showed no statistically significant interaction associations between social isolation and feelings of loneliness.
Conclusions Older adults with social isolation or loneliness tended to experience chronic pain, emphasizing the importance of incorporating social support and community engagement into chronic pain treatment strategies.
Formation and sustenance mechanism of bacterial diversity in nutrient-deficient environment of indoor stadium
Authors: Sun Lei , Wen Xiao , Li Lei , Li Min , Xing Xiaodong , Zhang Zhiyong , DONG Chen 
Published: June 2024

Abstract

Bacterial diversity has been found in indoor stadiums which can be considered as a specific nutrient-deficient environment (NDE), it remains a mystery and opens to new ideas why the bacterial diversity can be formed and maintained in NDE of indoor stadiums, since it is obvious to violate the famous competitive exclusion principle (CEP) in ecology. In the article, five most common genera, Pseudomonas, Acinetobacter, Exiguobacterium, Sphingobacterium, Chryseobacterium in indoor stadiums were selected and periodically sampled to supervise the dynamic characteristics of bacterial community. Based on quorum sensing (QS) and non-monotonic interspecific interaction (NMII) in combination with microbial ecology, clustering analysis and experimental observation, a new hypothesis was put forward to elucidate QS with NMII of substrate location information (SLI) mechanism driving bacterial community succession with high diversity in NDE of indoor stadium. A valid cellular automation (CA) model was derived from assumptions directly, and the CA simulation sufficiently proved that as a cell conducted either intraspecific and interspecific competition without SLI broadcasting and intraspecific and interspecific cooperation with SLI broadcasting, which were totally dependent on the number and type of cells occupying on its eight nearest neighboring grids, and could effectively weaken interspecific competition to form and sustain the bacterial diversity during bacterial community succession in NDE of indoor stadium. The CA simulation results proved that the proposed hypothesis can shed light on the underlying succession mechanism of bacterial community in NDE, and adequately explain observed phenomena and data. The finding of study offered a new insight on how bacterial diversity was formed and sustained in NDE of indoor stadium, and the succession mechanism confirmed by CA simulation can set up a theoretical framework for comprehensive apprehension about ecological effect of QS with NMII of SLI sharing on formation and sustenance of bacterial diversity in NDE of indoor stadium.
Socioeconomic equity in maternal health services use in Bangladesh: The role of service readiness in health facilities during the period 2001–2016
Authors: Ahsan Karar Zunaid , Angeles Gustavo , Curtis Siân L , Streatfield Peter Kim , Singh Kavita 
Published: June 2024

Abstract

Background
Equity in health services use is related to utilizing equal treatment for equal health needs, irrespective of socioeconomic status. Inequity in maternal health services use in low- and middle-income countries has become a central public health policy and research issue in recent years to achieve universal health coverage by 2030. For Bangladesh, we examined if the socioeconomic equity for selected maternal health services use (viz., antenatal care from a medically trained provider, facility delivery, and management of complications) improved more in districts with high facility readiness than in the rest of the country during 2001‒2016.
Methods
We used data from three rounds of the Bangladesh Maternal Mortality and Health Care Survey and corresponding rounds of the Bangladesh Health Facility Survey to estimate the differential effect of facility readiness on equity in maternal health services use during 2001‒2016. We applied an adaptation of the Difference-in-Differences (DID) model based on linear probability models on a pooled dataset of 2001, 2010, and 2016 household surveys linked to corresponding health facility surveys.
Results
Bangladesh has made impressive improvements in the overall use of maternal health services, but the increase was not uniform for all the population groups. Though there have been modest improvements in equity for ANC and treatment for complications, inequity for facility delivery increased noticeably between 2001 and 2016. The nonpoor-poor gap in the high facility readiness districts increased faster than in the low readiness districts during 2001‒2016, resulting in a more inequitable distribution of facility delivery services (p < 0.05). We also found that ANC became more equitable between 2001 and 2016 among women living < 1 hour from a private facility (p < 0.05).
Conclusions
This is the first systematic investigation of the role of facility readiness on maternal health equity in Bangladesh using nationally representative data. This study found persistent socioeconomic inequities in the use of all three key maternal health services, and for facility delivery, socioeconomic inequity worsened over time. The empirical evidence and policy measures presented here provide a way forward for policymakers to provide equitable care for safe delivery services in Bangladesh.
Detection of Narcoleptic and Veer tendencies using Machine Learning and Sensors
Authors: Dubey Saurav K. , PRASAD RAKESH K. , Singh Dilip K. 
Published: June 2024

Abstract

In recent years, road safety has been a matter of great concern world-wide with increasing number of accidents annually. Narcolepsy and Veer tendencies are a major source for the cause of accidents in today's world. The Drowsiness and Fatigue levels affect the mindset of the drivers which causes accidents. The proposed system uses a hybrid network of computer vision and physical sensor equipped on a prototype. Comparison is done between Yolo and Haar model. The system uses Haar Cascade Classifier to detect the eye iris state and the sensors work as a confirmatory test to validate the results. CHT (Circular Hough Transform) is used to detect the circular shape of the eye and to detect the eye iris state detection. The algorithm localizes tracks and analyses both the driver face and eyes to measure the eye iris visual state. The sensor ADXXL 335 measures the veer tendencies using gravitation acceleration (g) experienced by the prototype during traversing from one direction to the other.
RFCACSP-YOLOv8n: Automatic Detection and Grading of Disk Herniation and Central Canal Stenosis in Lumbar Magnetic Resonance Images
Authors: Guo Yan , Huang Xiaoxiang , Chen Wei , Nakamoto Ichiro , Chen Hua , Feng jie , Wu Jianfeng 
Published: June 2024

Abstract

Background:Low back pain (LBP) is a prevalent symptom worldwide, and lum-bar magnetic resonance imaging (MRI) is a crucial technique for elucidating the etiology of LBP. However, interpreting these complex MR images is repetitive and time-consuming for radiologists. In addition, medical professionals with different experience levels may make different interpretations. This study evaluated the YOLOv8n model to detect and automatically grade lumbar disk herniation (LDH) and lumbar central canal stenosis (LCCS) in lumbar axial MRI.
Methods: A total of 273 and 100 lumbar axial T2w MR images obtained from the Pingtan Branch of Fujian Medical University Union Hospital from January 2023 to December 2023 were used as training and testing datasets, respectively. Three clinicians annotated all MR images according to the MSU and Schizas grading standards. The receptive-field coordinated attention and cross-stage part YOLOv8n (RFCACSP-YOLOv8n) based on YOLOv8n comprises a backbone network for feature extraction, a neck network for multiscale information fusion, 1 and a head network for regression prediction. Our team has designed a module named RFCACSP to replace the C2f module. The RFCACSP module adopts the concept of a cross-stage partial network and integrates a receptive-field coordinated attention convolutional module that was improved based on coordinated attention. In addition, we reduced the number of layers in the neck network from three to two. The improved model is named RFCACSP-YOLOv8n. We used the YOLOv8n and RFCACSP-YOLOv8n models to detect and automatically grade LDH and LCCS on axial T2w MR images of the lumbar spine and compared the performance of the two models. Box precision (boxes), recall (R), mean average precision at an IoU threshold of 0.5 (mAP50), and mean average precision from an IoU threshold of 0.5–0.95 (mAP50-95) were used to assess the performance of the model on the datasets.
Result:Confusion matrix statistics based on the datasets provided by the Ping-tan Branch of Fujian Medical University Union Hospital found more samples classified as LDH grade 1A and 1C and LCCS grade A2. On the test dataset, RFCACSP-YOLOv8n outperforms YOLOv8n, showing 1.9% and 2.3% improvement in mAP and mAP50-95, respectively. Furthermore, RFCACSP-YOLOv8n could focus on improving the prediction accuracy of the major grades in the region, with grades 1A, 1C, and A2.
Conclusion: The RFCACSP-YOLOv8n model demonstrated excellent performance in detecting and automatically grading LDH and LCCS on axial T2w MR images.
Considering Well-being Orientation: the Eudaimonic and Hedonic Dataset for Well-being-centered Recommender Systems
Authors: Joers Julian Marvin , De Luca Ernesto William 
Published: June 2024

Abstract

Human-Computer Interaction (HCI) is undergoing a paradigm shift toward placing well-being at the center of technology development. Information systems (IS) research is called upon to align business goals with different well-being orientations, particularly those of hedonic and eudaimonic individuals. While hedonic-oriented individuals choose relaxation and pleasure as their goals, eudaimonic-oriented individuals are interested in meaningful experiences that go beyond pleasure. Surprisingly, there is a lack of datasets provided for recommender systems (RS) considering well-being orientations. We developed and thus present the first public dataset in this paper that was created based on an online survey with 229 participants. Respondents were asked to name their favorite movies and books and then the participants were clustered into two orientations using the HEMA-Revised (HEMA-R) Scale. In total, we collected 1,563 items (799 movies and 764 books). The dataset is intended to contribute to the improvement of (group) RS architectures.
Nephroprotective Effect of Ferula assa-foetida Oleo Gum Resin on Type 2 Diabetic Rats
Authors: Bagheri Seyyed Majid , Hakimizadeh Elham , Allahtavakoli Mohammad 
Published: June 2024

Objective:
Diabetic nephropathy is one of the main causes of kidney failure in the end stage of diabetes
worldwide. On the other hand, asafoetida is a gum whose hypoglycemic effects have been proven. The
present study was conducted with the aim of using asafoetida to prevent diabetic nephropathy.

Methods:
Diabetes was induced by a high-fat diet (60%) and streptozotocin injection (35 mg/kg) in rats. Diabetic
rats were treated with an oral dose of 50 mg/kg of asafoetida for 8 weeks. At the end of the experiment,
serum and urine parameters were examined. Antioxidant enzymes and lipid peroxidation levels in the kidney
were also determined along with its histological examination. The expression levels of tumor necrosis factor-alpha
and Transforming growth factor beta genes were also evaluated.

Results:
Glucose, cholesterol, triglyceride, and HbA1c concentrations were significantly reduced in the asafoetida
50. On the other hand, in the treatment group, serum creatinine, urea, and albumin levels decreased and
increased in urine. Antioxidant enzymes in the kidney improved significantly, and the expression of tumour necrosis
factor-alpha and transforming growth factor-beta genes decreased. Histopathological examination also
showed that necrosis, epithelial damage, and leukocyte infiltration increased in the diabetic and decreased in
the treatment group.

Conclusion:
The result of biochemical analysis, enzymatic, and histological examinations showed that asafoetida
may delay the progression of diabetic nephropathy due to the presence of anti-inflammatory and antioxidant
activities.
Network Pharmacology and Molecular Docking Validation to Explore the Pharmacological Mechanism of Zhuling Decoction against Nephrotic Syndrome
Authors: Chen Na , Chu Yanqi , Su Su , Zhang Qingxia , Zhang Lan 
Published: June 2024

Background:
In recent years, the incidence and prevalence of Nephrotic Syndrome (NS) have been
increasing. Zhuling decoction (ZLD), a classical Chinese medicine, has been clinically proven to be effective
for the treatment of NS. However, its underlying mechanism and pharmacodynamic substances remain unclear.

Objective:
This study aimed to explore the mechanism of action and chemical components of ZLD against NS
using network pharmacology and molecular docking.

Methods:
Traditional Chinese Medicine Systems Pharmacology (TCMSP), Bioinformatics Analysis Tool for
Molecular Mechanism of Traditional Chinese Medicines (BATMAN-TCM), and SwissTargetPrediction
databases were used to screen the principal ingredients and the associated targets of ZLD. NS-related targets
were obtained from the Online Mendelian Inheritance in Man (OMIM), GeneCards, Therapeutic Target
Database (TTD), and Drugbank databases. Shared targets were derived by the intersection of ZLD- and NS-associated
targets. Protein-interaction relationships were analyzed using the STRING database and Cytoscape. A
visualized drug-active compound-target network of ZLD was established using Cytoscape. Analyses of gene
enrichment were performed using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes
(KEGG) methods by the Database for Annotation, Visualization, and Integrated Discovery (DAVID) database.
Molecular docking was performed to assess the binding activity between active components and hub targets.

Results:
Polyporusterone E, cerevisterol, alisol B, and alisol B 23-acetate were the primary potential ingredients
of ZLD. HMGCR, HSD11B1, NOS2, NR3C1, and NR3C2 were the hub targets of ZLD against NS.
Molecular docking showed that polyporusterone E, cerevisterol, and alisol B had high binding activities with
targets HMGCR, HSD11B1, and NOS2.

Conclusion:
In summary, this study suggests that the main active compounds (polyporusterone E, cerevisterol,
alisol B) may have important roles for ZLD acting against NS by binding to hub targets (HMGCR, HSD11B1,
and NOS2) and modulating PI3K-Akt, Ras, MAPK, and HIF-1 signaling pathways.
Synthesis of Polynuclear Aromatic Hydrocarbons by Palladium-catalyzed C-H Bond
Functionalization
Authors: Dewan Mitali , Bera Sachinath , Samanta Shubhankar , Kundu Debasish , Jana Rathin 
Published: June 2024

:
Nowadays palladium-catalyzed C–H bond activation is a useful
approach for the synthetic transformation of organic compounds due to
step economy, the use of non-prefunctionalized substrates and reduced
chemical wastes. Among the various synthetic strategies, palladium catalyzed
intra and inter-molecular C–H bond activation has recently drawn a
lot of interest to synthesize the decorated π-conjugated polycyclic aromatic
hydrocarbon. In this review, we have focused on recent progress
along with previous strategies to synthesize various polynuclear aromatic
hydrocarbons (PAHs) by the use of Pd-catalyzed C–H bond activation.
We have also discussed the mechanistic details of the reaction intra and
inter-molecular C–H bond activation.
In silico/vitro Study of Antibacterial Effects of Non-toxic Cinnamic Amidoesters on Artemia salina
Authors: Almeida-Júnior Alexandre , Souza Helivaldo Diógenes da Silva , Sousa Abraão Pinheiro de , Dantas Maria Vitória Oliveira , Sampaio Fabio Correia , Luis Jose Alixandre de Sousa , Rodrigues-Junior Valnês da Silva , Barbosa-Filho José Maria , Fiss Gabriela Fehn , Athayde-Filho Petrônio Filgueiras de 
Published: June 2024

Abstract:
According to the PLOS Neglected Tropical Diseases Journal, infection caused by the Gram-negative
bacterium Escherichia coli is a neglected tropical disease. Staphylococcus aureus is the most dangerous Grampositive
bacterium among staphylococcal bacteria. Moreover, resistance to Mycobacterium tuberculosis is an
urgent public health issue. In this sense, cinnamic acid and acetamide derivatives have been used as strategic
nuclei in the design of antimicrobial agents. With the aim of investigating whether antibacterial activity is improved
with the junction of cinnamic and acetamide nuclei, cinnamic amidoesters were planned and evaluated
as potential antibacterial agents. In silico (ADMET test and molecular docking) and in vitro (antibacterial and
antituberculosis evaluation, and toxicity on Artemia salina larvae) studies were performed. Twelve cinnamic
amidoesters were synthesized, which present positive characteristics for possible drug candidates, and showed
subtle activity against E. coli, however, against S. aureus, unsubstituted and para-substituted compounds (R3 =
H, Me, Cl, Br) showed significant activity, with MIC = 156.25-625 μg.mL-1. Only one para-substituted compound
(R3 = Bu) showed discrete activity against M. tuberculosis, with MIC = 200 μM. For the most active
compounds against S. aureus, the molecular docking study demonstrated affinity with the TtRNA enzyme,
which plays a central role in the assembly of amino acids into polypeptide chains. The most active compounds
against S. aureus and M. tuberculosis were non-toxic on A. salina, with LC50 > 1000 μg.mL-1. According to in
silico/vitro studies, the non-toxic compound 5h (R3 = Cl) stands out as a potential antibacterial agent for further
studies.