bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suffering and the Affirmation of Life
Authors: Clark Maudemarie 
Published: April 2012

Abstract
Bernard Reginster's book The Affirmation of Life (2006) purports to fill a gap in our understanding of Nietzsche's philosophical project by explaining why Nietzsche regards the affirmation of life as his defining philosophical achievement. Reginster is not alone in emphasizing the centrality of life affirmation to Nietzsche's thought. What makes Reginster's book new and original is his systematic approach—his attempt to isolate a core of Nietzsche's philosophy and show how everything else, especially the affirmation of life, is related to it. This article challenges the systematicity Reginster finds in Nietzsche's work; above all, it rejects Reginster's claim that what has led to nihilism is the condemnation of suffering, a view Nietzsche is said to inherit from Schopenhauer. I raise questions about how much of Schopenhauer's view Nietzsche in fact retains and about how well Reginster's account of affirmation fits with Nietzsche's account of the will to power, which, as I have argued elsewhere, has played an essential part in producing all the things Nietzsche values.
Metaethics and Nihilism in Reginster's The Affirmation of Life
Authors: J. Z. Hussain Nadeem 
Published: April 2012

Abstract
Bernard Reginster, in his book The Affirmation of Life: Nietzsche on Overcoming Nihilism, takes up the challenge of figuring out what Nietzsche might mean by nihilism and the revaluation of values. He argues that there is an alternative, normative subjectivist interpretation of Nietzsche's views on nihilism and revaluation that makes as much sense as—indeed, he often clearly leans toward thinking that it makes more sense than—a fictionalist reading of Nietzsche. I argue that his arguments do not succeed. Once we have looked carefully at the details of the positions and the arguments ascribed to Nietzsche, the fictionalist option is the more charitable interpretation of the texts. I focus on the metaethical issues that play a central role for Reginster in his articulation of Nietzsche's nihilism and Nietzsche's strategy for overcoming nihilism.
Latent Futures of Iranian Architecture
Authors: Hensel Michael 
Published: April 2012

AbstractHow is it possible to draw on inherited technical and cultural knowledge while being projective and anticipating an evolving future? Michael Hensel highlights the value of recognising essential Iranian sensibilities and identifying salient past traits that can be redeveloped into an enlightened contemporary approach. What sort of novel amalgamations might point towards the most promising futures for Iranian architectural design?
Brief Report: Candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity
Authors: Koumakis Eugénie , Giraud Matthieu , Dieudé Philippe , Cohignac Vanessa , Cuomo Giovanna , Airò Paolo , Hachulla Eric , Matucci‐Cerinic Marco , Diot Elizabeth , Caramaschi Paola , Mouthon Luc , Riccieri Valeria , Cracowski Jean‐Luc , Tiev Kiet Phong , Francès Camille , Amoura Zahir , Sibilia Jean , Cosnes Anne , Carpentier Patrick , Valentini Gabriele , Manetti Mirko , Guiducci Serena , Meyer Olivier , Kahan André , Boileau Catherine , Chiocchia Gilles , Allanore Yannick 
Published: April 2012

AbstractObjectiveSystemic lupus erythematosus (SLE) and systemic sclerosis (SSc) share some pathophysiologic bases as evidenced by individual and familial polyautoimmunity and common susceptibility genetic factors. With regard to the latter, there has been a recent shift from the “common variant” to the “rare variant” paradigm, since rare variants of TNFAIP3 and TREX1 with large effect sizes have recently been discovered in SLE. The present study was undertaken to investigate whether rare variants of TNFAIP3 and TREX1 are also associated with SSc.MethodsTREX1 single‐nucleotide polymorphisms (SNPs) rs3135946, rs7626978, rs3135943, and rs11797 and TNFAIP3 SNPs rs9494883, rs72063345, rs5029939, rs2230926, rs117480515, and rs7749323 were genotyped in a discovery set (985 SSc patients and 1,011 controls), and replication analysis of the most relevant results was performed in a second set (622 SSc patients and 493 controls).ResultsNo association between TREX1 variants and SSc was observed. For TNFAIP3, we first demonstrated that a low‐frequency variant, rs117480515, tagged the recently identified TT>A SLE dinucleotide. In the discovery sample, we observed that all tested TNFAIP3 variants were in linkage disequilibrium and were associated with SSc and various SSc subsets, including the polyautoimmune phenotype. We subsequently genotyped rs117480515 in the replication sample and found it to be associated solely with the SSc polyautoimmune subset (odds ratio 3.51 [95% confidence interval 2.28–5.41], P = 8.58 × 10−9) in the combined populations. Genotype–messenger RNA (mRNA) expression correlation analysis revealed that the TNFAIP3 rs117480515 risk allele was associated with decreased mRNA expression.ConclusionThe present findings establish the TNFAIP3 locus as a susceptibility factor for the subset of SSc with a polyautoimmune phenotype. Our results support the implication of rare/low‐frequency functional variants and the critical role of A20 in autoimmunity.
The conundrum of sharing research data
Authors: Borgman Christine L. 
Published: April 2012

We must all accept that science is data and that data are science, and thus provide for, and justify the need for the support of, much‐improved data curation. (Hanson, Sugden, & Alberts, )Researchers are producing an unprecedented deluge of data by using new methods and instrumentation. Others may wish to mine these data for new discoveries and innovations. However, research data are not readily available as sharing is common in only a few fields such as astronomy and genomics. Data sharing practices in other fields vary widely. Moreover, research data take many forms, are handled in many ways, using many approaches, and often are difficult to interpret once removed from their initial context. Data sharing is thus a conundrum. Four rationales for sharing data are examined, drawing examples from the sciences, social sciences, and humanities: (1) to reproduce or to verify research, (2) to make results of publicly funded research available to the public, (3) to enable others to ask new questions of extant data, and (4) to advance the state of research and innovation. These rationales differ by the arguments for sharing, by beneficiaries, and by the motivations and incentives of the many stakeholders involved. The challenges are to understand which data might be shared, by whom, with whom, under what conditions, why, and to what effects. Answers will inform data policy and practice.
Shaping the niche: Lessons from the Drosophila testis and other model systems
Authors: Papagiannouli Fani , Lohmann Ingrid 
Published: April 2012

AbstractStem cells are fascinating, as they supply the cells that construct our adult bodies and replenish, as we age, worn out, damaged, and diseased tissues. Stem cell regulation relies on intrinsic signals but also on inputs emanating from the neighbouring niche. The Drosophila testis provides an excellent system for studying such processes. Although recent advances have uncovered several signalling, cytoskeletal and other factors affecting niche homeostasis and testis differentiation, many aspects of niche regulation and maintenance remain unsolved. In this review, we discuss aspects of niche establishment and integrity not yet fully understood and we compare it to the current knowledge in other model systems such as vertebrates and plants. We also address specific questions on stem cell maintenance and niche regulation in the Drosophila testis under the control of Hox genes. Finally, we provide insights on the striking functional conservation of homologous genes in plants and animals and their respective stem cell niches. Elucidating conserved mechanisms of stem cell control in both lineages could reveal the importance underlying this conservation and justify the evolutionary pressure to adapt homologous molecules for performing the same task.
ChemInform Abstract: Investigation of Heterodimeric and Homodimeric Radical Cations of the Series: [F2O2]+, [F2Cl2]+, [Cl2O2]+, [F4]+, and [Cl4]+.
Authors: Schloeder Tobias , Riedel Sebastian 
Published: April 2012

AbstractStructures, thermochemical stability, Born‐Fajans‐Haber cycles, and vibrational data of the title ions are quantum‐chemically obtained by coupled‐cluster calculations with single and double substitution as well as perturbative triple excitations.
ChemInform Abstract: Synthesis of Pd Nanoparticles on Heteropolyacid‐Supported Silica by a Photoassisted Deposition Method: An Active Catalyst for the Direct Synthesis of Hydrogen Peroxide.
Authors: Mori Kohsuke , Furubayashi Ken , Okada Shusuke , Yamashita Hiromi 
Published: April 2012

AbstractA Cs2.5H0.5PW12O40/SiO2 support material is prepared by evaporation of aqueous mixtures of SiO2, H3PW12O4, and Cs2CO3 followed by calcination at 673 K for 2 h in air.
ChemInform Abstract: White Phosphorus as a Ligand for the Coinage Metals.
Authors: Forfar Laura C. , Clark Timothy J. , Green Michael , Mansell Stephen M. , Russell Christopher A. , Sanguramath Rajashekharayya A. , Slattery John M. 
Published: April 2012

AbstractCopper and silver form coordination complexes with P4 whereas gold forms a homoleptic [Au(P4)2]+ cation.
ChemInform Abstract: Facile Synthesis of the High‐Pressure Polymorph of Nanocrystalline LiFePO4 at Ambient Pressure and Low Temperature.
Authors: Voss Benjamin , Nordmann Joerg , Kockmann Alexander , Piezonka Jennifer , Haase Markus 
Published: April 2012

AbstractNanocrystalline high‐pressure LiFePO4 having the CrVO4 type structure (space group Cmcm) is synthesized at ambient pressure from a solution of FeCl2, LiCl, diphenylether, and tri‐n‐octylphosphine oxide in MeOH (100 °C, 1 h) mixed with a solution containing H3PO4, tri‐n‐hexylamine, and dihexylether (N2, 150 °C, 1 h).
ChemInform Abstract: Synthesis, Structure, and Optical Properties of BiCuOCh (Ch: S, Se, and Te).
Authors: Richard A. P. , Russell J. A. , Zakutayev A. , Zakharov L. N. , Keszler D. A. , Tate J. 
Published: April 2012

AbstractCrystals of the title compounds are prepared from salt fluxes and characterized by powder XRD, single crystal XRD for (VIII), and IR diffuse reflectance and transmission measurements.
ChemInform Abstract: A Diels—Alder Approach to the Enantioselective Construction of Fluoromethylated Stereogenic Carbon Centers.
Authors: Shibatomi Kazutaka , Kobayashi Fumito , Narayama Akira , Fujisawa Ikuhide , Iwasa Seiji 
Published: April 2012

AbstractDiels—Alder reactions of β‐fluoromethylacrylates in the presence of a Lewis acid activated chiral oxazaborolidine catalyst provide access to fluoromethylated cyclohexenes with very high enantioselectivity.
ChemInform Abstract: Ecofriendly and Efficient Procedure for Hetero‐Michael Addition Reactions with an Acidic Ionic Liquid as Catalyst and Reaction Medium.
Authors: Dabiri Minoo , Salehi Peyman , Bahramnejad Mahboobeh , Baghbanzadeh Mostafa 
Published: April 2012

Abstract1‐Hexyl‐3‐methylimidazolium trifluoroacetate is shown to be a reusable, efficient and mild catalyst for Michael addition reactions of amines and thiols with a variety of appropriate acceptors.
ChemInform Abstract: Palladium‐Catalyzed Asymmetric Synthesis of 2‐Alkynyl Oxacycles.
Authors: Daniels David S. B. , Thompson Amber L. , Anderson Edward A. 
Published: April 2012

AbstractCyclic and acyclic propargylic carbonates undergo unusual palladium‐catalyzed cyclization reactions to give 2‐alkynyl oxacycles.
ChemInform Abstract: Development of More Labile Low Electron Count Co(I) Sources: Mild, Catalytic Functionalization of Activated Alkanes Using a [(Cp*Co)2‐μ‐(η4:η4‐arene)] Complex.
Authors: Hung‐Low Fernando , Krogman Jeremy P. , Tye Jesse W. , Bradley Christopher A. 
Published: April 2012

AbstractCatalytic transfer dehydrogenation of silyl‐protected amines is achieved under mild conditions using the title bridging cobalt arene complex.
ChemInform Abstract: Selective Reductions of the Carbonyl Compounds and Aryl Halides with Ni—Al Alloy in Aqueous Alkali Medium.
Authors: Suceveanu Mirela , Raicopol Matei , Enache Raluca , Finaru Adriana , Rosca Sorin I. 
Published: April 2012

AbstractThe relative reactivities of the presented compounds in the title reaction are investigated and provide an evidence for a direct electron transfer from aluminum to the organic substrate.
ChemInform Abstract: Selective Monobenzoylation of 1,2‐ and 1,3‐Diols Catalyzed by Me2SnCl2 in Water (Organic Solvent Free) under Mild Conditions.
Authors: Muramatsu Wataru , William Julius M. , Onomura Osamu 
Published: April 2012

AbstractA new, efficient, and environmentally friendly method to prepare monoacylated 1,2‐ and 1,3‐diols is reported.
ChemInform Abstract: Synthesis of Enantioenriched γ‐Quaternary Cycloheptenones Using a Combined Allylic Alkylation/Stork—Danheiser Approach: Preparation of Mono‐, Bi‐, and Tricyclic Systems.
Authors: Bennett Nathan B. , Hong Allen Y. , Harned Andrew M. , Stoltz Brian M. 
Published: April 2012

AbstractThe addition of Grignard or organolithium compounds to enantioenriched vinylogous ester (I) followed by finely tuned quenching conditions affords β‐functionalized cycloheptenones.
ChemInform Abstract: Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2‐Aminopyridines as an Expedient Route to Imidazo[1,2‐a]pyridines.
Authors: Liu Ping , Deng Chun‐Lin , Lei Xinsheng , Lin Guo‐Qiang 
Published: April 2012

AbstractImidazo[1,2‐a]pyridines are prepared in a new tandem route from aryl propargylic alcohols (I) and 2‐aminopyridines in the presence of ZnCl2 and CuCl.
ChemInform Abstract: A General Approach to the Enantioselective α‐Oxidation of Aldehydes via Synergistic Catalysis.
Authors: Simonovich Scott P. , Van Humbeck Jeffrey F. , MacMillan David W. C. 
Published: April 2012

AbstractThe Sibi oxyamination of aldehydes (including both antipodes of citronellal) in the presence of CuCl2/IMD produces the α‐oxy derivatives with good to excellent e.e.
ChemInform Abstract: Direct Use of Dioxygen as an Oxygen Source: Catalytic Oxidative Synthesis of Amides.
Authors: Wei Wei , Hu Xiao‐Yu , Yan Xiao‐Wei , Zhang Qiang , Cheng Ming , Ji Jian‐Xin 
Published: April 2012

AbstractA transition‐metal‐catalyzed direct oxidative synthesis of amides from alkynes and amines under mild conditions is presented.
ChemInform Abstract: A Thiophosphoryl Chloride Assisted Transformation of Arylaldoximes to Thioamides.
Authors: Pandey Lokesh Kumar , Pathak Uma , Mathur Sweta , Suryanarayana M. V. S. 
Published: April 2012

AbstractIn the presented synthesis of the compounds (II) and (IV) aryl nitriles are the intermediates.
ChemInform Abstract: Ligand‐Accelerated Cross‐Coupling of Cs(sp2)—H Bonds with Arylboron Reagents.
Authors: Engle Keary M. , Thuy‐Boun Peter S. , Dang Michael , Yu Jin‐Quan 
Published: April 2012

AbstractAn improved method for the coupling of phenylacetic acids with arylboron compounds is reported.
ChemInform Abstract: Rapid Access to 3‐Aryltetralin Skeleton via C(sp3)—H Bond Functionalization: Investigation on the Substituent Effect of Aromatic Ring Adjacent to C—H Bond in Hydride Shift/Cyclization Sequence.
Authors: Mori Keiji , Sueoka Shosaku , Akiyama Takahiko 
Published: April 2012

AbstractA concise construction of the 3‐aryltetralin skeleton via hydride shift mediated C—H bond functionalization is achieved.
ChemInform Abstract: Synthesis of Indanones by Sequential Heck Reduction—Cyclization—Alkylation (HRCA) Reactions.
Authors: Nassar‐Hardy Luma , Fabre Sandy , Amer Atef M. , Fouquet Eric , Felpin Francois‐Xavier 
Published: April 2012

AbstractA one‐pot four‐step reaction sequence for the synthesis of indanones bearing a quarternary carbon center is disclosed.
ChemInform Abstract: Room‐Temperature Palladium‐Catalyzed Coupling of Heteroaryl Amines with Aryl or Heteroaryl Bromides.
Authors: Moss Thomas A. , Addie Matthews S. , Nowak Thorsten , Waring Michael J. 
Published: April 2012

AbstractOptimized reaction conditions are developed for the Buchwald—Hartwig amination.
ChemInform Abstract: Expanded Scope of Heterocyclic Biaryl Synthesis via a Palladium‐Catalyzed Thermal Decarboxylative Cross‐Coupling Reaction.
Authors: Kissane Marie , McNamara Orla A. , Mitchell David , Coppert David M. , Moynihan Humphrey A. , Lorenz Kurt T. , Maguire Anita R. 
Published: April 2012

AbstractAn interesting synthesis of 2‐aryl‐substituted thiophenes (III) is achieved through coupling of the potassium carboxylate (I) with aryl halides, especially bromides.
ChemInform Abstract: Synthesis of 5‐Amino‐3H‐pyrrole‐3,4‐dicarbonitriles from 4‐Aryl‐4‐oxobutane‐1,1,2,2‐tetracarbonitriles.
Authors: Belikov M. Yu. , Ershov O. V. , Lipovskaya I. V. , Eremkin A. V. , Nasakin O. E. 
Published: April 2012

AbstractThe structure of derivative (IIIa) is proved by X‐ray analysis.
ChemInform Abstract: Pericyclic Cascade with Chirality Transfer: Reaction Pathway and Origin of Enantioselectivity of the Hetero‐Claisen Approach to Oxindoles.
Authors: Celebi‐Oelcuem Nihan , Lam Yu‐hong , Richmond Edward , Ling Kenneth B. , Smith Andrew D. , Houk Kendall N. 
Published: April 2012

Abstract3,3‐Disubstituted oxindoles are synthesized from N‐phenylnitrones and ketenes.
ChemInform Abstract: Synthesis of Imidazolyl Dithiocarbamates and Their Reactions with Phenacyl Bromides.
Authors: El'tsov O. S. , Mokrushin V. S. , Smirnova M. V. , Shafikov M. Z. 
Published: April 2012

AbstractReaction of title compounds (I) with various phenacyl bromides leads to S‐alkylation products (III) as a mixture of E/Z‐isomers.
ChemInform Abstract: Blue‐Luminescent 5‐(3‐Indolyl)oxazoles via Microwave‐Assisted Three‐Component Coupling—Cycloisomerization—Fischer Indole Synthesis.
Authors: Grotkopp Oliver , Ahmad Atia , Frank Walter , Mueller Thomas J. J. 
Published: April 2012

AbstractThe novel microwave‐assisted one‐pot three‐step synthesis of title indolyloxazoles consists of Sonogashira coupling of propargylic amides (I) with acyl chlorides (II), followed by acid‐catalyzed cycloisomerization of the so obtained ynones to oxazoles and Fischer indole formation with aromatic hydrazines (III).
ChemInform Abstract: Reactions of Malonodithioamides with Acetylenedicarboxylic Esters.
Authors: Obydennov K. L. , Kosterina M. F. , Klimareva E. L. , Bakulev V. A. , Morzherin Yu. Yu. 
Published: April 2012

AbstractThe unsubstituted malonodithioamide (I) and N‐substituted malonodithioamide (IV) react with acetylenedicarboxylates to give a system of 2 conjugated thiazolidine heterocycles containing exocyclic double bonds.
ChemInform Abstract: Synthesis of 1,2,3‐Triazole‐Fused Heterocycles via Pd‐Catalyzed Cyclization of 5‐Iodotriazoles.
Authors: Schulman Jacqueline M. , Friedman Adam A. , Panteleev Jane , Lautens Mark 
Published: April 2012

AbstractAn efficient strategy for the construction of annulated triazoles is presented.
ChemInform Abstract: Highly Enantioselective Friedel—Crafts Alkylation Reaction Catalyzed by Rosin‐Derived Tertiary Amine—Thiourea: Synthesis of Modified Chromans with Anticancer Potency.
Authors: Jiang Xianxing , Wu Lipeng , Xing Yanhong , Wang Long , Wang Shoulei , Chen Zongyao , Wang Rui 
Published: April 2012

AbstractSeveral of the chromans of type (IV) show in vitro cytotoxic activity against 6 different tumor cell lines.
ChemInform Abstract: Structure of Diethyl (Polyfluorobenzoyl)malonates and Their Thermal Intramolecular Cyclization.
Authors: Bazhin D. N. , Schegol'kov E. V. , Kudyakova Yu. S. , Burgart Ya. V. , Saloutin V. I. 
Published: April 2012

AbstractPolyfluorobenzoyl chlorides (I) react with the C‐ethoxymagnesium derivative of diethyl malonate to give the (polyfluorobenzoyl)malonates (III).
ChemInform Abstract: Task‐Specific Ionic Liquid as the Recyclable Catalyst for the Rapid and Green Synthesis of Dihydropyrano[3,2‐a]chromene Derivatives
Authors: Shaterian Hamid Reza , Honarmand Moones 
Published: April 2012

Abstractvia three‐component reaction of 4‐hydrooxycoumarin (I) with aldehydes and malononitrile; 17 examples
ChemInform Abstract: A Facile Transformation of Amino Acids to Functionalized Coumarins.
Authors: Bandyopadhyay Anupam , Gopi Hosahudya N. 
Published: April 2012

AbstractA variety of novel chiral coumarins (IV) and (VII) is prepared by cyclization of amino acid‐derived dicarbonyl compounds (I) and (V) with methoxyphenol (II) in the presence of methylsulfonic acid.
ChemInform Abstract: Synthesis of New Functionally Substituted 2‐Oxo(thioxo)nicotinic Acid Amides and Nitriles by SNVin Reaction.
Authors: Dyachenko V. D. , Bityukova O. S. , Dyachenko A. D. 
Published: April 2012

AbstractNew title compounds are synthesized by condensation of 3,3‐bis(methylsulfanyl)acrylonitriles with CH acidic compounds through nucleophilic vinylic substitution.
ChemInform Abstract: Regioselective C—H Bond Functionalizations of Acridines Using Organozinc Reagents.
Authors: Hyodo Isao , Tobisu Mamoru , Chatani Naoto 
Published: April 2012

AbstractProtocols for the regioselective alkylation or arylation of acridines at the 4‐ and 9‐positions, are described.
ChemInform Abstract: Ruthenium‐Catalyzed Aerobic Oxidative Coupling of Alkynes with 2‐Aryl‐Substituted Pyrroles.
Authors: Ackermann Lutz , Wang Lianhui , Lygin Alexander V. 
Published: April 2012

AbstractA broad spectrum of pyrrole and indole substrates can be used in coupling reactions with internal aryl or alkyl alkynes.
ChemInform Abstract: Microwave Irradiation for Accelerating Synthesis of 5,6‐Diphenylimidazo[1,2‐a]pyrimidines Based on Isoflavones.
Authors: Han Wen‐Yong , Zhang Zun‐Ting , Qiu Li , Li Gang 
Published: April 2012

AbstractNovel imidazo[1,2‐a]pyrimidines (III) are synthesized by a microwave‐assisted cyclocondensation reaction.
ChemInform Abstract: Synthesis and Characterization of New Derivatives of 1,4‐Diazepinium Salts.
Authors: Mehranpour A. M. , Hashemnia S. , Shayan Z. 
Published: April 2012

AbstractA variety of novel 6‐aryldiazepinium and 3‐arylbenzodiazepinium salts is synthesized by reactions of corresponding 3‐aryl‐1,5‐diazapentadienium salts with 1,2‐diamines.
ChemInform Abstract: Synthesis and Characterization of Wurtzite‐Phase Copper Tin Selenide Nanocrystals.
Authors: Norako Michelle E. , Greaney Matthew J. , Brutchey Richard L. 
Published: April 2012

AbstractWurtzite‐phase Cu2SnSe3 colloidal nanocrystals are synthesized by fast addition of tBu2Se2 to a solution of CuCl and SnI4 in dodecylamine and 1‐dodecanethiol at 180 °C, followed by heating for 5 min.
ChemInform Abstract: Mimicking Nature to Make Unnatural Amino Acids and Chiral Diamines
Authors: So Soon Mog , Kim Hyunwoo , Mui Leo , Chin Jik 
Published: April 2012

AbstractReview: use of a chiral pyridoxal model to make unnatural α‐amino acids with excellent stereoselectivity, chiral diamines from a chiral pyridoxamine model, computational studies; ca. 130 refs.
Scale‐up via Miniplant Technique: Examples of Homogeneous Catalysis
Authors: Behr Arno , Witte Henning , Zagajewski Michael 
Published: April 2012

AbstractBei der Entwicklung eines neuen chemischen Verfahrens gilt es, die Zeitspanne vom ersten Laborversuch bis hin zum technischen Verfahren rigoros zu minimieren, um der Dynamik des sich rasch entwickelnden Marktes gerecht zu werden. Im vorliegenden Beitrag werden die Vorteile der Miniplant‐Technik im Hinblick auf eine effiziente Verfahrensentwicklung dargestellt. Hierbei werden konkrete Beispiele homogen katalysierter Verfahren vorgestellt, welche in Form kontinuierlich betriebener Miniplants erfolgreich realisiert wurden.