bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women and men with distressing low sexual desire exhibit sexually dimorphic brain processing
Authors: Ertl Natalie , Mills Edouard G. , Wall Matthew B. , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Bassett Paul A. , Howard Jonathan , Rabiner Eugenii A. , Abbara Ali , Goldmeier David , Comninos Alexander N. , Dhillo Waljit S. 
Published: May 2024

AbstractDistressing low sexual desire, termed Hypoactive Sexual Desire Disorder (HSDD), affects approximately 10% of women and 8% of men. In women, the ‘top-down’ theory of HSDD describes hyperactivity in higher-level cognitive brain regions, suppressing lower-level emotional/sexual brain areas. However, it is unknown how this neurofunctional disturbance compares to HSDD in men. To investigate this, we employed task-based functional MRI in 32 women and 32 men with HSDD to measure sexual-brain processing during sexual versus non-sexual videos, as well as psychometric questionnaires to assess sexual desire/arousal. We demonstrate that women had greater activation in higher-level and lower-level brain regions, compared to men. Indeed, women who had greater hypothalamic activation in response to sexual videos, reported higher psychometric scores in the evaluative (r = 0.55, P = 0.001), motivational (r = 0.56, P = 0.003), and physiological (r = 0.57, P = 0.0006) domains of sexual desire and arousal after watching the sexual videos in the scanner. By contrast, no similar correlations were observed in men. Taken together, this is the first direct comparison of the neural correlates of distressing low sexual desire between women and men. The data supports the ‘top-down’ theory of HSDD in women, whereas in men HSDD appears to be associated with different neurofunctional processes.
Arranged and non-arranged marriages have similar reproductive outcomes in Nepal
Authors: Agey Elizabeth 
Published: May 2024

AbstractMuch of the evolutionary literature on mate choice presumes that individual mate preferences function to increase individual fitness, and this assumption has been confirmed in several experimental studies with animals. However, human mate choice, in many cultures, is heavily controlled by parents via arranged marriages, rather than the selection of the marrying individuals. Several studies have demonstrated that parents and offspring do not exhibit identical preferences for an in-law or spouse, respectively. If parental choice thwarts offspring’s evolved mate preferences from being expressed, then arranged marriages should reduce fitness. Using data from the Chitwan Valley Family Study, I examined whether having an arranged marriage, as compared to a non-arranged marriage, is associated with differences in total births, offspring survival to age 15, or interbirth intervals in Nepal, a culture with a rich history of arranged marriage. I find that there are no differences in any reproductive outcomes between arranged, co-selected, and self-selected marriages. These results indicate that individuals in arranged and non-arranged marriages may achieve similar fitness outcomes via different pathways, which may be unique to human mating systems.
The STING inhibitor (ISD-017) reduces glomerulonephritis in 129.B6.Fcgr2b-deficient mice
Authors: Alee Isara , Chantawichitwong Papasara , Leelahavanichkul Asada , Paludan Søren R. , Pisitkun Trairak , Pisitkun Prapaporn 
Published: May 2024

AbstractThe absence of stimulator of interferon genes (STING) in 129.B6.Fcgr2b-deficient mice rescue lupus phenotypes. The administration of a STING inhibitor (ISD017) into the young 129.B6.Fcgr2b-deficient mice prevents lupus nephritis development. This study mainly aimed to evaluate the effects of STING inhibition (ISD107) on established SLE in mice to prove that ISD017 could be a good therapeutic drug to reverse the already set-up autoimmunity and kidney impairment. Twenty-four-week-old Fcgr2b-deficient mice were treated with cyclophosphamide (25 mg/kg, intraperitoneal, once per week), ISD017 (10 mg/kg, intraperitoneal, three times per week), or control vehicle for 8 weeks, and were analyzed for phenotypes. Both ISD017 and cyclophosphamide treatment increased long-term survival and reduced the severity of glomerulonephritis in Fcgr2b-deficient mice. While cyclophosphamide reduced activated B cells (B220+GL-7+), ISD017 decreased activated T cells (CD4+CD69+) and neutrophils (Ly6c+Ly6g+) in Fcgr2b-deficient mice. In addition, ISD017 reduced IL-1β and interferon-inducible genes. In summary, ISD017 treatment in symptomatic 129.B6.Fcgr2b-deficient mice reduced the severity of glomerulonephritis and increased long-term survival. ISD017 worked comparably to cyclophosphamide for treating lupus nephritis in 129.B6.Fcgr2b-deficient mice. ISD017 reduced activated T cells and neutrophils, while cyclophosphamide targeted activated B cells. These results suggested that STING inhibitors can potentially be a new therapeutic drug for treating lupus.
Development of multiple input supply based modified SEPIC DC–DC converter for efficient management of DC microgrid
Authors: Reddy B. Nagi , Alsaif Faisal , Reddy Ch. Rami , Sunil Kumar Sunkara 
Published: May 2024

AbstractThe development of DC microgrids is reliant on multi-input converters, which offer several advantages, including enhanced DC power generation and consumption efficiency, simplified quality, and stability. This paper describes the development of a multiple input supply based modified SEPIC DC–DC Converter for efficient management of DC microgrid that is powered by two DC sources. Here Multi-Input SEPIC converter offers both versatility in handling output voltage ranges and efficiency in power flow, even under challenging operating conditions like lower duty cycle values. These features contribute to the converter's effectiveness in managing power within a DC microgrid. In this configuration, the DC sources can supply energy to the load together or separately, depending on how the power switches operate. The detailed working states with equivalent circuit diagrams and theoretical waveforms, under steady-state conditions, are shown along with the current direction equations. This paper also demonstrates the typical analysis of large-signal, small-signal, steady-state modeling techniques and detailed design equations. The proposed configuration is validated through the conceptual examination using theoretical and comprehensive MATLAB simulation results. Detailed performance analysis has been done for different cases with various duty ratios. Finally, to show the competitiveness, the multi-input SEPIC topology is compared with similar recent converters.
Bacteria inhabiting spider webs enhance host silk extensibility
Authors: Tsiareshyna Maryia , Wang Te-Hsin , Lin Ying-Sheng , Piorkowski Dakota , Huang Sammi Yen-Ting , Huang Yi-Lun , Chao Wei-Ting , Chang Yuan Jay , Liao Chen-Pan , Wang Pi-Han , Tso I-Min 
Published: May 2024

AbstractSpider silk is a promising material with great potential in biomedical applications due to its incredible mechanical properties and resistance to degradation of commercially available bacterial strains. However, little is known about the bacterial communities that may inhabit spider webs and how these microorganisms interact with spider silk. In this study, we exposed two exopolysaccharide-secreting bacteria, isolated from webs of an orb spider, to major ampullate (MA) silk from host spiders. The naturally occurring lipid and glycoprotein surface layers of MA silk were experimentally removed to further probe the interaction between bacteria and silk. Extensibility of major ampullate silk produced by Triconephila clavata that was exposed to either Microbacterium sp. or Novosphigobium sp. was significantly higher than that of silk that was not exposed to bacteria (differed by 58.7%). This strain-enhancing effect was not observed when the lipid and glycoprotein surface layers of MA silks were removed. The presence of exopolysaccharides was detected through NMR from MA silks exposed to these two bacteria but not from those without exposure. Here we report for the first time that exopolysaccharide-secreting bacteria inhabiting spider webs can enhance extensibility of host MA silks and silk surface layers play a vital role in mediating such effects.
On the evidence of helico-spiralling recirculation within coherent cores of eddies using Lagrangian approach
Authors: Deogharia Rahul , Gupta Hitesh , Sil Sourav , Gangopadhyay Avijit , Shee Abhijit 
Published: May 2024

AbstractOceanic eddies exhibit remarkable coherence and longevity compared to other transient features in the surrounding flow. They possess the ability to transport properties over extensive distances while maintaining their material identity intact. The Lagrangian Coherent Structure (LCS) framework has proven effective in capturing these coherent eddies, where they display a solid-body-like rotation. Although various LCS approaches have been employed to investigate different facets of coherent eddies, a comprehensive understanding of their three-dimensional structures and internal dynamics remains elusive. This study aims to advance our comprehension of coherent eddies’ structural characteristics and delve into the precise nature of their internal dynamics by utilizing the Lagrangian Averaged Vorticity Deviation approach. Two eddies, one cyclonic and the other anti-cyclonic, were chosen from a high-resolution simulation carried out in the Bay of Bengal using the Regional Ocean Modeling System (ROMS). The findings unveil that these eddies have three-dimensional coherent cores resembling gently tapered cones that are broader at the surface and gradually narrow towards the bottom. Intriguingly, the dynamically coherent core of these eddies exhibits simultaneous upwelling and downwelling while maintaining their volumes during advection due to persistent material coherence. The three-dimensional trajectories followed by the fluid parcels inside the coherent core are helical. Their two-dimensional horizontal projections show alternating spiral bands of upwelling and downwelling which are the manifestations of Vortex Rossby Waves. These observations lead to a conceptual framework of a three-dimensional helico-spiralling recirculation pattern within the coherent cores of eddies.
Aluminium Chloride instead of Ferric chloride for inducing superior sagittal sinus thrombosis to reduce ferromagnetic artifacts on MRI-imaging in experimental models
Authors: Hachenberger Maaike , Braun Tobias , Gerner Stefan T. , Suenner Laura , Schänzer Anne , Juenemann Martin , Mueller Clemens , Wietelmann Astrid , Stolz Erwin , Schoenburg Markus , Tschernatsch Marlene , Gerriets Tibo , Huttner Hagen B. , Yeniguen Mesut 
Published: May 2024

AbstractUsing ferric chloride (FeCl3) to induce experimental superior sagittal sinus (SSS) thrombosis might interfere with magnetic resonance imaging (MRI)-assisted visualization and evaluation of the thrombus, the brain parenchyma, and the quality of the occlusion. The aim of this study was to investigate whether aluminum chloride (AlCl3)-induced thrombosis of the SSS has comparable properties to those of FeCl3 without causing artifacts in MRI. SSS thrombosis was induced in 14 male Wistar rats by exposure of the SSS and subsequent topical application of a filter paper strip soaked in AlCl3 (n = 7) or FeCl3 (n = 7) over a period of 15 min. The animals with AlCl3-induced SSS thrombosis showed a constant and complete occlusion with in histological analysis large thrombi. Blood flow measurements indicated a significant reduction on the first and seventh postoperative day compared to preoperative measurements. MRI enabled visualization and subsequent evaluation of the thrombus and the surrounding parenchyma. In comparison, FeCl3-induced SSS thrombosis could not be evaluated by MRI due to artifacts caused by the paramagnetic properties and increased susceptibility of FeCl3. The occluded sinus and the surrounding area appeared hypointense. The quality of SSS occlusion by AlCl3 was comparable to that of FeCl3. AlCl3 therefore represents a significant alternative substance in experimental SSS thrombosis ideally suited for studies using MRI.
Unexpected HCHO transnational transport: influence on the temporal and spatial distribution of HCHO in Tibet from 2013 to 2021 based on satellite
Authors: Xu Yizhou , Su Wenjing , Hu Qihou , Zhang Chengxin , Javed Zeeshan , Tian Yuan , Hou Hongri , Liu Cheng 
Published: May 2024

AbstractFormaldehyde (HCHO) is a serious hazardous air pollutant and crucial precursor of PM2.5 and ozone compound pollution. There has been a dearth of HCHO research in Tibet where pressing need to protect the unique ecosystem. Therefore, this study aims to investigate the spatial-temporal distribution of HCHO from 2013 to 2021 and identify its influencing factors using satellite observations. Our findings reveal a noteworthy annual growth rate of 2.25% yr−1 in HCHO vertical column density (VCD) in Tibet. This rate is comparable to that in India and even surpasses levels observed in many other regions worldwide, including eastern China. Furthermore, unlike other areas, the eastern region of Tibet exhibits no discernible seasonal pattern in HCHO VCD. The anomalous variation in HCHO concentrations in Tibet can primarily be attributed to long-distance transnational transport originating from incomplete combustion in India Assam. Our research underscores the urgent need for enhanced atmospheric environmental management in Tibet.
Multi-isotope reconstruction of Late Pleistocene large-herbivore biogeography and mobility patterns in Central Europe
Authors: Heddell-Stevens Phoebe , Jöris Olaf , Britton Kate , Matthies Tim , Lucas Mary , Scott Erin , Le Roux Petrus , Meller Harald , Roberts Patrick 
Published: May 2024

AbstractInterpretations of Late Pleistocene hominin adaptative capacities by archaeologists have focused heavily on their exploitation of certain prey and documented contemporary behaviours for these species. However, we cannot assume that animal prey-taxa ecology and ethology were the same in the past as in the present, or were constant over archaeological timescales. Sequential isotope analysis of herbivore teeth has emerged as a particularly powerful method of directly reconstructing diet, ecology and mobility patterns on sub-annual scales. Here, we apply87Sr/86Sr isotope analysis, in combination with δ18O and δ13C isotope analysis, to sequentially sampled tooth enamel of prevalent herbivore species that populated Europe during the Last Glacial Period, includingRangifer tarandus,Equussp. andMammuthus primigenius. Our samples come from two open-air archaeological sites in Central Germany, Königsaue and Breitenbach, associated with Middle Palaeolithic and early Upper Palaeolithic cultures, respectively. We identify potential inter- and intra-species differences in range size and movement through time, contextualised through insights into diet and the wider environment. However, homogeneous bioavailable87Sr/86Sr across large parts of the study region prevented the identification of specific migration routes. Finally, we discuss the possible influence of large-herbivore behaviour on hominin hunting decisions at the two sites.
The association between being breastfed in infancy and risks of cancer in adulthood—a UK Biobank study
Authors: Hameiri-Bowen Dan , Pedersen Dorthe C. , Jensen Britt W. , Aarestrup Julie , Rasmussen Kathleen M. , Baker Jennifer L. , Bjerregaard Lise G. 
Published: May 2024

Abstract
Background
Being breastfed has established benefits for infant health, but its long-term effects on adult diseases, including cancer, remain underexplored. We examined associations between being breastfed in infancy and the risks of common cancers.

Methods
Data from 339,115 participants (191,117 women) enrolled in the UK Biobank with self-reported breastfeeding data were linked to national cancer registries. Cox models estimated sex-specific hazard ratios (HR) and 95% confidence intervals (CI) for the associations between being breastfed (ever/never) and risks of overall cancer as well as common cancer sites.

Results
In total, 34,392 incident cancers (17,895 in women) were registered. The HR of overall cancer associated with being breastfed was 1.05 (95% CI 1.01–1.09) in women and 1.00 (95% CI 0.96–1-04) in men. In site-specific analysis being breastfed was associated with an increased risk of breast and ovarian cancer in women and a reduced risk of oesophageal cancer in men.

Discussion
We found that having been breastfed was associated with a marginally increased risk of adult cancer in women, but we found no evidence of an association in men. These findings should be viewed within the study limitations, and do not outweigh the many benefits that breastfeeding provides.
Solvent effects on carbohydrate transformation: insights into chemical pathway modulation
Authors: Sun Yaxu , Tong Zhihan , Yu Yanyan , Cheng Wanke , Li Yilin , Zeng Suqing , Lou Yuhan , Liu Yongzhuang , Xia Qinqin , Yu Haipeng 
Published: May 2024

Solvent effects are pivotal steps in carbohydrate utilization by modulating solute-solvent interactions.
YOLO‐DFT: An object detection method based on cloud data fusion and transfer learning for power system equipment maintenance
Authors: Wang Kai , Zhang Xu , Sun Yifan , Xu Tianyi , Li Jiqiao , Cao Song 
Published: May 2024

AbstractObject detection techniques have been widely used in power system equipment maintenance. However, in power systems, the accuracy of object detection is limited by the scarcity of publicly available datasets and the lack of scene pertinence. In order to solve these problems, an object detection method based on cloud data fusion and transfer learning (YOLO‐DFT) for power system equipment maintenance is proposed. Illustratively, YOLO‐DFT focuses on the object detection task involving birds and humans, generating a substantial and resilient human‐bird dataset through cloud‐based data fusion to compensate for the dearth of public datasets in the power system domain. By seamlessly integrating the YOLOv5 algorithm with a transfer learning strategy, a targeted detection mechanism for specific locations is meticulously formulated. The experimental results demonstrate that YOLO‐DFT effectively addresses object detection challenges in power systems, achieving a Mean Average Precision (MAP) measure of 0.925 across all classes, thereby providing a valuable reference for the maintenance of power system equipment.
Enhanced LSTM‐DQN algorithm for a two‐player zero‐sum game in three‐dimensional space
Authors: Lu Bo , Ru Le , Lv Maolong , Hu Shiguang , Zhang Hongguo , Zhao Zilong 
Published: May 2024

AbstractTo tackle the challenges presented by the two‐player zero sum game (TZSG) in three‐dimensional space, this study introduces an enhanced deep Q‐learning (DQN) algorithm that utilizes long short term memory (LSTM) network. The primary objective of this algorithm is to enhance the temporal correlation of the TZSG in three‐dimensional space. Additionally, it incorporates the hindsight experience replay (HER) mechanism to improve the learning efficiency of the network and mitigate the issue of the “sparse reward” that arises from prolonged training of intelligence in solving the TZSG in the three‐dimensional. Furthermore, this method enhances the convergence and stability of the overall solution.An intelligent training environment centred around an airborne agent and its mutual pursuit interaction scenario was designed to proposed approach's effectiveness. The algorithm training and comparison results show that the LSTM‐DQN‐HER algorithm outperforms similar algorithm in solving the TZSG in three‐dimensional space. In conclusion, this paper presents an improved DQN algorithm based on LSTM and incorporates the HER mechanism to address the challenges posed by the TZSG in three‐dimensional space. The proposed algorithm enhances the solution's temporal correlation, learning efficiency, convergence, and stability. The simulation results confirm its superior performance in solving the TZSG in three‐dimensional space.
Research on cascaded multilevel converters for dual motor drive systems based on a nine‐switch converter
Authors: Wang Pan , Xu Hu , Yuan Lei 
Published: May 2024

AbstractIn order to address the issues of complexity, high cost, large volume, and low reliability associated with traditional H‐bridge cascaded converters when operating under high voltage, high capacity, and dual electric motor loads, the authors propose the utilisation of a nine‐switch converter as an alternative to the conventional H‐bridge converter for implementing cascaded multilevel converters in dual electric motor drive systems. After conducting an analysis and research on the topology and operational control strategy of cascaded multilevel converters based on the nine‐switch converter, a design is presented using six individual nine‐switch converter units to develop a cascaded multilevel converter capable of driving two 3 MW asynchronous electric motors at a 6 kV voltage level. Simulation verification is performed, and a scaled‐down prototype is built for experimental validation. The results demonstrate that, in comparison to traditional H‐bridge cascaded converters, the proposed cascaded multilevel converter can effectively drive dual electric motors at the same or different frequencies while reducing the number of switches to 1/4, the total transformer windings to 1/2, and Direct Current‐side capacitors to 1/6. This improvement enhances system reliability, portability, and load adaptability, thus offering increased versatility in dual electric motor drive applications.
Graph‐based solution for smart grid real‐time operation and control
Authors: Mohamed Ayman M. O. , El‐Shatshat Ramadan 
Published: May 2024

AbstractUnder the envisioned smart grid paradigm, there is an increasing demand for a fast, accurate, and efficient power flow solution for distribution system operation and control. Various solution techniques have been proposed, each with its own unique formulation, solution methodology, advantages, and drawbacks. Motivated by challenges associated with the integration of renewable distributed energy resources and electric vehicles into distribution systems and further by the speed and convergence limitations of existing tools, this paper presents a novel graph‐based power flow solution for smart grid's real‐time operation and control, named Flow‐AugmentationPF algorithm. The proposed method formulates a power flow problem as a network‐flow problem and solves it by using a maximum‐flow algorithm, inspired by the push‐relabel max‐flow technique. The performance of the proposed algorithm is tested and validated using several benchmark networks of different sizes, topologies, and parameters and compared against the most commonly used solution techniques and commercial software packages, namely PSS/E and PSCAD. The proposed formulation is simple, accurate, fast, yet computationally efficient, as it is based on matrix‐vector multiplication, and is also scalable, considering the formulation works as a graph‐based method, which, inherently, allows for parallel computation for added computational speed.