bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of graphics‐based digital twin framework for UAV‐aided post‐earthquake inspection of high‐rise buildings
Authors: Wang Jingjing , Wu Yongjingbang , Wang Shuo , Narazaki Yasutaka , Liu Hai , Spencer Billie F. 
Published: May 2024

SummaryTraditional post‐earthquake inspection of civil infrastructure is conducted manually, taking a considerable amount of time and often putting inspectors in harm's way. This problem is exacerbated in modern cities, where millions of people can be left homeless until their residences are deemed safe to reinhabit. Image collection enabled by commercial unmanned aerial vehicles (UAVs) combined with computer vision‐based techniques has provided an alternative with high potential for rapid post‐earthquake inspection. However, the extracted images of the damage alone are inadequate to evaluate the system‐level safety condition of a structure. The quality of the visual information also heavily relies on the effectiveness of the UAV inspection scheme which is susceptible to environmental uncertainties. To this end, a graphics‐based digital twin (GBDT) framework is developed for UAV‐aided post‐earthquake inspection of high‐rise buildings and validated using a high‐rise building in Guangzhou, China. The GBDT is comprised of a finite element (FE) model and a photorealistic computer graphics (CG) model, with the latter being informed by the former, jointly providing as a comprehensive virtual representation of the structure so that every step of the post‐earthquake inspection procedure can be planned and evaluated virtually. First, to avoid the cumbersome nature of constructing the graphical representation of the numerous components in high‐rise buildings, the CG model in the GBDT is created by automatically importing structural components from the FE model and adding nonstructural components according to the dimensions of the as‐built structure. This fast modeling process as well as the accuracy of the virtual presentation are validated by point cloud comparisons between the CG model and the as‐built structure. Subsequently, the GBDT is used to showcase the evaluation of UAV flight schemes for post‐earthquake inspection of high‐rise buildings. To shorten flight time and place more emphasis on potential damage, FE analysis is conducted to determine the earthquake‐induced damage locations. Consistent damage hotspots are then marked on the CG model, along with restrictions from the real environment such as obstacles, weak satellite signal, wind speed, and lighting conditions considered in the synthetic environment. Finally, applying the synthetic environment as the testbed, three UAV‐aided inspection schemes are implemented virtually and the best UAV flight scheme is determined for the assumed field inspection. This example demonstrates the flexibility of the GBDT in representing the real‐world structure and environmental conditions and its efficacy in assisting decision making for rapid and effective structural inspection in the aftermath of an earthquake.
Classification of Selaginellaceae and responses to “Rebuttal to ‘(2943) Proposal to conserve Selaginella, nom. cons., (Selaginellaceae) with a conserved type’: An unwarranted and disruptive idea”
Authors: Zhou Xin‐Mao , Zhang Li‐Bing 
Published: May 2024

AbstractThe proposal by Wan & al. intended to maintain maximal nomenclatural stability by proposing to conserve Selaginella (Selaginellaceae) with a conserved type, regardless of how and when Selaginella is to be split into several or more genera, as has already been done in some recent studies. Valdespino & al. do not seem to have understood the nomenclatural benefit of the Wan & al. proposal and mix up this proposal with the classification by Zhou & Zhang. In addition, their rebuttal paper appears to contain a number of issues. We respectably urge the Nomenclature Committee and the botanical community to reject their rebuttal and make a decision that will benefit long‐term nomenclatural stability in Selaginellaceae.
New Theoretical and Practical Horizons in Data‐driven Learning: Introduction to the Special Issue
Authors: Casal J. Elliott , Kessler Matt 
Published: May 2024

AbstractThis paper introduces readers to the TESOL Quarterly special topic issue: Assessing the effectiveness of corpus‐based approaches to English language teaching. The authors open by briefly defining and outlining data‐driven learning (DDL) research on second language (English) teaching. This is followed by an extended discussion of four themes, which pertain to recent developments and future directions in DDL. These themes include: (1) selecting corpora for corpus‐based language teaching; (2) pushing the boundaries of DDL; (3) preparing language educators for corpus‐based language teaching; and (4) reflecting on theory and methods. Throughout the piece, readers are also introduced to those contributions within the special issue, which include a diverse range of pieces that focus on aspects of theory, research, and pedagogy.
Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO‐1/GPX4 pathway
Authors: Huang Lei , Wang Jiayi , Yu Jieqin , Bian Mengxuan , Xiang Xingdong , Han Guanjie , Chen Weisin , Wang Ning , Ge Jun , Lu Shunyi , Zhang Jian 
Published: May 2024

AbstractOsteoporosis (OP) can result in slower bone regeneration than the normal condition due to abnormal oxidative stress and high levels of reactive oxygen species (ROS), a condition detrimental for bone formation, making the OP‐related bone healing a significant clinical challenge. As the osteogenic differentiation ability of bone marrow mesenchymal stem cells (BMSCs) is closely related to bone regeneration; currently, this study assessed the effects of Picein on BMSCs in vitro and bone regeneration in osteoporotic bone defect in vivo. Cell viability was determined by CCK‐8 assay. The production of (ROS), malonaldehyde, superoxide dismutase activities, and glutathione was evaluated by using commercially available kits, and a flow cytometry analysis was adopted to detect macrophage polarization. Osteogenic capacity of BMSCs was evaluated by alkaline phosphatase (ALP) activity, ALP staining, and Alizarin red S staining. The expression of osteogenic‐related proteins (OPN, Runx‐2, OCN) and osteogenic‐related genes (ALP, BMP‐4, COL‐1, and Osterix) were evaluated by Western blotting and real‐time PCR (RT‐PCR). In addition, proliferation, migration ability, and angiogenic capacity of human umbilical vein endothelial cells (HUVECs) were evaluated by EdU staining, scratch test, transwell assay, and tube formation assay, respectively. Angiogenic‐related genes (VEGF, vWF, CD31) were also evaluated by RT‐PCR. Results showed that Picein alleviated erastin‐induced oxidative stress, enhanced osteogenic differentiation capacity of BMSCs, angiogenesis of HUVECs, and protects cells against ferroptosis through Nrf2/HO‐1/GPX4 axis. Moreover, Picein regulate immune microenvironment by promoting the polarization of M2 macrophages in vitro. In addition, Picein also reduce the inflammation levels and promotes bone regeneration in osteoporotic bone defect in OP rat models in vivo. Altogether, these results suggested that Picein can promote bone regeneration and alleviate oxidative stress via Nrf2/HO‐1/GPX4 pathway, offering Picein as a novel antioxidant agent for treating osteoporotic bone defect.
Governing communal diversity as good governance
Authors: Koos Agnes K. , Keulman Kenneth 
Published: May 2024

AbstractThis study asks whether existing standards of good governance have incorporated ideals and measures to manage communal diversity. The context is an intellectual landscape in which the efficacy of heterogeneity policies has typically been compared through their impact on the likelihood of violent conflict. Alternate approaches would fine‐tune the outcome variable and/or enlist new independent variables. The Ethnic Power Relations project provided measures of the groups' co‐determination position (egip, excl) and measures of empowerment through self‐governing start to follow suit, such as improved indicators of territorial autonomies, decentralization, and language use rights. We also crafted a measure of functional autonomies, based on the ENTA Network's case‐study collection. With the exception of territorial autonomies, all existing measures of policies that accommodate the difference tend to improve the group's relationships with other groups and with the country as a whole. They also correlate well with the general good governance indicators.
Time‐resolved photoelectron spectroscopy via trajectory surface hopping
Authors: Chakraborty Pratip , Matsika Spiridoula 
Published: May 2024

AbstractTime‐resolved photoelectron spectroscopy is a powerful pump‐probe technique which can probe nonadiabatic dynamics in molecules. Interpretation of the experimental signals however requires input from theoretical simulations. Advances in electronic structure theory, nonadiabatic dynamics, and theory to calculate the ionization yields, have enabled accurate simulation of time‐resolved photoelectron spectra leading to successful applications of the technique. We review the basic theory and steps involved in calculating time‐resolved photoelectron spectra, and highlight successful applications.This article is categorized under:
Electronic Structure Theory > Ab Initio Electronic Structure Methods
Theoretical and Physical Chemistry > Spectroscopy
Iron oxide nanoparticles for treatment and diagnosis of chronic inflammatory diseases: A systematic review
Authors: Ansari Shaquib Rahman , Mahajan Jessica , Teleki Alexandra 
Published: May 2024

AbstractChronic inflammatory conditions are among the most prevalent diseases worldwide. Several debilitating diseases such as atherosclerosis, inflammatory bowel disease, rheumatoid arthritis, and Alzheimer's are linked to chronic inflammation. These conditions often develop into complex and fatal conditions, making early detection and treatment of chronic inflammation crucial. Current diagnostic methods show high variability and do not account for disease heterogeneity and disease‐specific proinflammatory markers, often delaying the disease detection until later stages. Furthermore, existing treatment strategies, including high‐dose anti‐inflammatory and immunosuppressive drugs, have significant side effects and an increased risk of infections. In recent years, superparamagnetic iron oxide nanoparticles (SPIONs) have shown tremendous biomedical potential. SPIONs can function as imaging modalities for magnetic resonance imaging, and as therapeutic agents due to their magnetic hyperthermia capability. Furthermore, the surface functionalization of SPIONs allows the detection of specific disease biomarkers and targeted drug delivery. This systematic review explores the utility of SPIONs against chronic inflammatory disorders, focusing on their dual role as diagnostic and therapeutic agents. We extracted studies indexed in the Web of Science database from the last 10 years (2013–2023), and applied systematic inclusion criteria. This resulted in a final selection of 38 articles, which were analyzed for nanoparticle characteristics, targeted diseases, in vivo and in vitro models used, and the efficacy of the therapeutic or diagnostic modalities. The results revealed that ultrasmall SPIONs are excellent for imaging arterial and neuronal inflammation. Furthermore, novel therapies using SPIONs loaded with chemotherapeutic drugs show promise in the treatment of inflammatory diseases.This article is categorized under:
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
An elliptic integrable deformation of the Principal Chiral Model
Authors: Lacroix Sylvain , Wallberg Anders 
Published: May 2024

Abstract
We introduce a new elliptic integrable σ-model in the form of a two-parameter deformation of the Principal Chiral Model on the group SLℝ(N), generalising a construction of Cherednik for N = 2 (up to reality conditions). We exhibit the Lax connection and $$ \mathcal{R} $$
R
-matrix of this theory, which depend meromorphically on a spectral parameter valued in the torus. Furthermore, we explain the origin of this model from an equivariant semi-holomorphic 4-dimensional Chern-Simons theory on the torus. This approach opens the way for the construction of a large class of elliptic integrable σ-models, with the deformed Principal Chiral Model as the simplest example.
Double-well instantons in finite volume
Authors: Ai Wen-Yuan , Alexandre Jean , Carosi Matthias , Garbrecht Björn , Pla Silvia 
Published: May 2024

Abstract
Assuming a toroidal space with finite volume, we derive analytically the full one-loop vacuum energy for a scalar field tunnelling between two degenerate vacua, taking into account discrete momentum. The Casimir energy is computed for an arbitrary number of dimensions using the Abel-Plana formula, while the one-loop instanton functional determinant is evaluated using the Green’s functions for the fluctuation operators. The resulting energetic properties are non-trivial: both the Casimir effect and tunnelling contribute to the Null Energy Condition violation, arising from a non-extensive true vacuum energy. We discuss the relevance of this mechanism to induce a cosmic bounce, requiring no modified gravity or exotic matter.
Stability of the de-Sitter universe: one-loop nonlocal f (R) gravity
Authors: Feng Haiyuan , Liao Yi , Yang Rong-Jia 
Published: May 2024

Abstract
With the method of the background field expansion, we investigate the one-loop quantization of the Euclidean nonlocal f (R) model in the de-Sitter universe. We obtain the ghost-free condition (GFC) based on the transformation from the Jordan frame to the Einstein frame and the classical stability condition (CSC) satisfied $${f}_{RR}^{\left(0\right)}-{\phi }_{0}{F}_{RR}^{\left(0\right)}<0$$. We present the on-shell and off-shell one-loop effective action and quantum stability condition (QSC) by utilizing the generalized zeta-function. We find that under the fulfillment of GFC, CSC and QSC are inconsistent.
Camrelizumab plus famitinib in previously chemo-immunotherapy treated patients with advanced NSCLC: results from an open-label multicenter phase 2 basket study
Authors: Ren Shengxiang , Xiong Anwen , Yu Jia , Wang Xicheng , Han Baohui , Pan Yueyin , Zhao Jun , Cheng Yufeng , Hu Sheng , Liu Tianshu , Li Yalun , Cheng Ying , Feng Jifeng , Yi Shanyong , Gu Shanzhi , Gao Shegan , Luo Yongzhong , Liu Ying , Liu Caigang , Duan Huijie , Wang Shuni , Yang Xinfeng , Fan Jia , Zhou Caicun 
Published: May 2024

Abstract
Background
The combination of immune checkpoint inhibitors and antiangiogenic agents has been effective in treating multiple cancers. This was further explored in an open-label, multicenter phase 2 basket study (NCT04346381), which evaluated the antitumor activity and safety of camrelizumab (an anti-PD-1 antibody) plus famitinib (a receptor tyrosine kinase inhibitor) in patients with advanced solid tumors. We herein report the findings from the cohort of advanced NSCLC patients who progressed after treatment with platinum-doublet chemotherapy and immunotherapy.

Methods
Eligible patients were enrolled and treated with camrelizumab (200 mg once every 3 weeks via intravenous infusion) and oral famitinib (20 mg once daily). The primary endpoint was the objective response rate (ORR). Secondary endpoints included the disease control rate (DCR), duration of response (DoR), progression-free survival (PFS), overall survival (OS), and safety.

Results
Forty patients were enrolled in this cohort, with a median follow-up duration of 11.5 months. Three patients (7.5%) achieved a partial response, and 29 patients (72.5%) achieved stable disease. The ORR and DCR with this combination regimen were 7.5% (95% CI, 1.6–20.4) and 80.0% (95% CI, 64.4–90.9), respectively. The median DoR was 12.1 months (95% CI, 10.3-not reached). The median PFS was 5.4 months (95% CI, 4.1–7.5), and the median OS was 12.1 months (95% CI, 9.1–16.7). The estimated 12-month OS rate was 51.5% (95% CI, 34.9–65.9). The most frequent grade 3 or higher treatment-related adverse events occurring in more than 5% of patients included hypertension (27.5%), palmar-plantar erythrodysesthesia syndrome (10%), decreased neutrophil count (10%), and proteinuria (7.5%).

Conclusion
Camrelizumab plus famitinib demonstrated favorable benefits in PFS and OS, along with manageable safety profiles, in patients with advanced NSCLC who progressed after platinum-doublet chemotherapy and immunotherapy. This finding warrants further exploration.
Cubitus varus deformity following paediatric supracondylar humeral fracture remodelling predominantly in the sagittal direction: A three-dimensional analysis of eighty-six cases
Authors: Miyake Tasuku , Miyamura Satoshi , Miki Ryo , Shiode Ryoya , Iwahashi Toru , Kazui Arisa , Yamamoto Natsuki , Tanaka Hiroyuki , Okada Seiji , Murase Tsuyoshi , Oka Kunihiro 
Published: May 2024

Abstract
Purpose
Three-dimensional (3D) capacity for remodelling in cubitus varus deformity (CVD) after paediatric supracondylar humeral fractures (PSHFs) remains unelucidated. This study investigated remodelling patterns after PSHFs by examining 3D deformity distribution over time after injury.

Methods
Computed tomography (CT) data of 86 patients with CVD after PSHFs were analysed. The 3D deformity angles in the sagittal, coronal, and axial directions were assessed and correlated with the duration between the age at injury and CT evaluation. For the subgroup analysis, we performed the same correlation analysis in a younger (< 8 years old) and an older group (≥ 8 years old); we categorized the duration into early (< 2 years), middle (≥ 2 to < 5 years), and late periods (≥ 5 years) and compared the deformity angles of each direction among the three groups.

Results
Sagittal deformity showed a moderate correlation with the duration of deformity (r = -0.54; P < 0.001), while coronal and axial deformities showed a negligible correlation. Sagittal deformity showed moderate correlations with the duration in the younger group (r = -0.62; P < 0.001) and weak correlations in the older group (r = -0.37; P = 0.091). In the sagittal direction, the deformity angle in the early period was significantly larger than those in the mid and late periods (P < 0.001). However, there were no significant differences among the three groups in the coronal and axial directions.

Conclusion
Sagittal deformities in CVDs are capable of remodelling, especially in the early period and at a younger age, whereas coronal and axial deformities are less likely to undergo remodelling.
“Biodiversity Offsetting” in Uganda’s Protected Areas: A Pathway to Restoration of Forest Biodiversity?
Authors: Kigonya Ritah , Byakagaba Patrick , Ssenyonjo Edward , Nakakaawa Jjunju Charlotte 
Published: May 2024

AbstractWith limited national financing for conservation, there is an increasing interest in using biodiversity offset funds to strengthen protected area management. Offsetting measures can potentially be used in the restoration of degraded protected areas. However, there are concerns related to the uncertainty of restoration outcomes and time-lags before the expected benefits can be observed. Using a case of the Gangu Central Forest Reserve in central Uganda, we contribute empirical findings showing the potential and limitations of biodiversity offsetting by means of the restoration of a degraded forest reserve. We use forest cover change analysis and community surveys to determine forest changes after eight years of offset implementation, and forest inventories to analyse the current forest structure and composition to ascertain taxonomic diversity recovery. The results revealed that biodiversity offsetting led to a 21% increase in Tropical High Forest cover, and enhanced restoration of forest species composition and diversity. However, attaining permanence of the restoration benefits requires the regulation of community forest resource access and use. Strengthening forest management capacity to monitor the offset sites and compensating impacted communities for foregone forest resource benefits are crucial for the successful implementation of biodiversity offsets.
An anteromedial stabilization procedure has the most protective effect on the anterior cruciate ligament in tibial external rotation. A human knee model study
Authors: Blanke Fabian , Boljen Matthias , Oehler Nicola , Lutter Christoph , Tischer Thomas , Vogt Stephan 
Published: May 2024

Abstract
Introduction
Anterior cruciate ligament (ACL) reconstruction remains associated with the risk of re-rupture and persisting rotational instability. Additional extraarticular anterolateral stabilization procedures stabilize the tibial internal rotation and lead to lower ACL failure rate and improved knee stability. However, data for additional stabilization of tibial external rotation is lacking and the importance of an anteromedial stabilization procedure is less well evaluated. Aim of this study is to investigate the influence of an extraarticular anteromedial stabilization procedure for the stabilization of the tibial external rotation and protection of the ACL from these rotational forces.

Methods
Internal and external rotations of the tibia were applied to a finite element (FE) model with anatomical ACL, posterior cruciate ligament (PCL), lateral collateral ligament (LCL), medial collateral ligament (MCL) and intact medial and lateral meniscus. Five additional anatomic structures (Anteromedial stabilization/anteromedial ligament, AML, augmented superficial medial collateral ligament, sMCL, posterior oblique ligament, POL, anterolateral ligament, ALL, and popliteal tendon, PLT) were added to the FE model separately and then combined. The force histories within all structures were measured and determined for each case.

Results
The anteromedial stabilization or imaginary AML was the main secondary stabilizer of tibial external rotation (90% of overall ACL force reduction). The AML reduced the load on the ACL by 9% in tibial external rotation which could not be achieved by an augmented sMCL (-1%). The AML had no influence in tibial internal rotation (-1%). In the combined measurements with all additional structures (AML, ALL, PLT, POL) the load on the ACL was reduced by 10% in tibial external rotation.

Conclusion
This study showed that an additional anteromedial stabilization procedure secures the tibial external rotation and has the most protective effect on the ACL during these external rotational forces.
Optical biosensors for diagnosis of COVID-19: nanomaterial-enabled particle strategies for post pandemic era
Authors: Tekin Yusuf Samil , Kul Seyda Mihriban , Sagdic Osman , Rodthongkum Nadnudda , Geiss Brian , Ozer Tugba 
Published: May 2024

AbstractThe COVID-19 pandemic underlines the need for effective strategies for controlling virus spread and ensuring sensitive detection of SARS-CoV-2. This review presents the potential of nanomaterial-enabled optical biosensors for rapid and low-cost detection of SARS-CoV-2 biomarkers, demonstrating a comprehensive analysis including colorimetric, fluorescence, surface-enhanced Raman scattering, and surface plasmon resonance detection methods. Nanomaterials including metal-based nanomaterials, metal–organic frame–based nanoparticles, nanorods, nanoporous materials, nanoshell materials, and magnetic nanoparticles employed in the production of optical biosensors are presented in detail. This review also discusses the detection principles, fabrication methods, nanomaterial synthesis, and their applications for the detection of SARS-CoV-2 in four categories: antibody-based, antigen-based, nucleic acid–based, and aptamer-based biosensors. This critical review includes reports published in the literature between the years 2021 and 2024. In addition, the review offers critical insights into optical nanobiosensors for the diagnosis of COVID-19. The integration of artificial intelligence and machine learning technologies with optical nanomaterial-enabled biosensors is proposed to improve the efficiency of optical diagnostic systems for future pandemic scenarios.
Graphical Abstract