bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of routine data reporting injuries requiring hospitalisation in Nepal: a secondary data analysis
Authors: Pandey Bidhya , Bray Isabelle , Joshi Sunil K , Mytton Julie A 
Published: June 2024

Background
Injuries are an important public health issue in Nepal, contributing significantly to both morbidity and mortality. There is no injury surveillance system available, however healthcare service use is routinely reported to central government using the Health Management Information System (HMIS). The study was conducted as part of a wider programme of research to explore the burden of injuries in Nepal, funded by the United Kingdom National Institute for Health and Care Research.

Objectives
To explore the utility of Health Management Information System data to understand the burden of injuries in Nepal, inequalities by age and sex, and changes over time.

Design
Secondary analysis of published data.

Setting
Nepal.

Data sources
We used published national HMIS data on hospitalised injuries in Nepal, between 2009/10 and 2016/17, classified using International Classification of Disease codes. We grouped codes to report data by injury type, using the Global Burden of Disease injury classification framework where possible. We calculated crude rates of total unintentional injuries and self-harm, and crude rates by year for each type of unintentional injury, with correlation coefficients to describe any trends over time.

Results
The trend in crude unintentional injury rate increased over time. Road traffic injury admissions increased from 4.28/100,000 (95% confidence interval 4.03 to 4.52) of the population in 2009/10 to 10.55/100,000 (95% confidence interval 10.17 to 10.92) in 2016/17 (r = 0.93), while admissions following poisoning almost halved over the same period, from 7.52/100,000 (95% confidence interval 7.19 to 7.84) to 3.62/100,000 (95% confidence interval 3.40 to 3.84) (r = –0.87). Inequalities by age and gender were noted: during the period 2014/15–2016/17, admissions following road traffic injury most commonly affected adults of working age (13.82/100,000; 95% confidence interval 13.50 to 14.14) and were 1.78 times more common in men (13.63/100,000; 95% confidence interval 13.27 to 13.99) than women (7.77/100,000; 95% confidence interval 7.49 to 8.05).

Limitations
The coding and completeness of the injury data currently limit the utility of their use for monitoring and decision-making.

Conclusions
The cause of injury admissions between 2009/10 and 2016/17 appears to have shifted over time, with trends varying by injury type. In the absence of an injury surveillance system, routine inpatient data collected through the HMIS has the potential to inform policy and practice.

Future work
Support to enhance the completeness of data collection, and accuracy and consistency of data coding has the potential to enhance the utility of this existing data system.

Funding
This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Global Health Research programme as award number 16/137/49.
THE INSTITUTE OF INSTRUCTIONS OF VOTERS TO DEPUTIES IN THE HISTORY OF STATE AND LAW OF RUSSIA
Authors:   Ogarev Mordovian State University, Saransk, Russian Federation, SUSHKOVA YU.N. 
Published: June 2024

The article examines the institution of voter orders in the history of the state and law of Russia, which has great potential as a mechanism for direct democracy and generalization of the aspirations and needs of the population at the present stage. The institution of orders is well known in the history of the Russian state and its individual regions. Historical examples of appeals to the people’s instructions to representatives of state authorities are given. The author concludes that the use of penalties can be a significant factor in overcoming social tension in society, developing ways to effectively solve problems of regional and local importance, as well as contributing to the growth of the authority of public authorities.	Keywords: INSTRUCTIONS FROM VOTERS, PEOPLE'S ORDERS, LEGAL CULTURE, PEOPLES OF
BBS Gene Expression and Its Diversity in the Genus Dendrobium
Authors: Takamiya Tomoko , Saito Manako , Miyamoto Aoi , Oikawa Mio , Zhang Liyue , Yanagihashi Kazuki , Okawa Erika , Takahashi Yuuka , Suzuki Yui , Watanabe Misaki , Yahagi Tadahiro , Matsuzaki Keiichi , Iijima Hiroshi , Yukawa Tomohisha , Ogura-Tsujita Yuki 
Published: June 2024

Dendrobium officinale Kimura & Migo in the genus Dendrobium of Orchidaceae is an important medicinal plant that produces various bibenzyl and phenanthrene derivatives. In some orchids, these derivatives have been reported to increase with fungal infection. Bibenzyl biosynthesis is regulated by bibenzyl synthase (BBS). Although six genes of the BBS family have been registered from D. officinale, their gene regulation mechanisms are unclear. The infection of Dendrobium with mycorrhizal fungi also reportedly increases the expression of genes involved in biosynthesis; however, the effect of mycorrhizal fungi on bibenzyl production is unknown. The present study examined the effects of three mycorrhizal fungi isolated from D. officinale on BBS gene expression and bibenzyl production over time. One of the Tulasnellaceae operational taxonomic units induced BBS gene expression and increased two representative bibenzyls, gigantol and dendrophenol, at specific time points. Furthermore, 19 BBS sequences were cloned from 12 Dendrobium species, and a phylogenetic analysis was performed. The results indicated that repeated BBS gene duplication occurred during the evolution of the genus, and further duplication occurred after speciation. These results suggest that it is possible to optimize metabolite production by selecting suitable symbiotic fungi.
EFFECTIVENESS OF NIPPLE STIMULATION ON LABOR PROGRESS : EVIDENCE BASED CARE REPORT
Authors: Ayu Nurjannah Triastika , Ulfah Kurniaty , Sriyanti Chris 
Published: June 2024

Introduction: Prolonged labor is labor that lasts more than 24 hours for primigravida and or 18 hours for multigravida. Prolonged labor is one of several causes of maternal and newborn mortality. As labor progresses, contractions become more frequent, longer and stronger in intensity. Adequate contractions are needed so that labor can take place normally. Nipple stimulation is one way that can be used in increasing uterine contractions. Nipple stimulation causes the breasts to become aroused which causes the intensity of uterine contractions due to the stimulation of the receptors to loosen. This action can be stopped if the contractions experienced have become strong and prolonged. This method is a cost beneficial and effective alternative to induction and augmentation of labor.
Objectives:To evaluate effectiveness of nipple stimulation on labor
Method: Electronic database literature searches, namely Pubmed and Google Scholar.
Result: Two articles were selected from the literature search and then critically reviewed. Based on the study of Gulbahtiyar Demirel and Hanan Ibrahim et al, it was found that nipple stimulation is effective in reducing the induction of elective labor and there is an effect of nipple stimulation on the progress of labor in laboring women.
Conclusion: In this case, nipple stimulation was effective on the progress of labor in laboring mothers.
PENANGANAN SAMPAH DI TEMPAT WISATA PANTAI X TAHUN 2023
Authors: Puspita Lista , Karmini Mimin 
Published: June 2024

Pantai X merupakan salah satu tempat wisata yang banyak diminati. Kegiatan wisata selain bisa bernilai ekomoni juga bisa menjadi penghasil sampah. Oleh karena itu, perlu penanganan yang baik agar tidak menimbulkan dampak buruk terutama untuk lingkungan dan kesehatan. Tujuan penelitian yaitu mengetahui timbulan sampah, tingkat pengetahuan pedagang dan petugas kebersihan, penanganan sampah tahap pemilahan, pewadahan, pengumpulan, pengangkutan, sarana prasarana dan pengurangan sampah dengan prinsip 3R. Populasinya seluruh pedagang berjumlah 30 orang dan petugas kebersihan 5 orang. Sampel pedagang dan petugas kebersihan diambil secara keseluruhan.Teknik pengumpulan data dengan cara penimbangan, wawancara dan observasi. Alat pengumpul data timbangan, kuesioner, lembar observasi, kamera. Analisa data univariat. Timbulan sampah selama 8 hari berturut-turut sebanyak 196.8 Kg/hari dengan rata-rata 24.6 Kg/hari, Tingkat pengetahuan pedagang 40% kategori baik, petugas kebersihan 100% baik. Tahap pemilahan sampah 100% tidak memenuhi syarat. Tahap pewadahan oleh pedagang 90% memenuhi syarat dan oleh petugas kebersihan 100% tidak memenuhi syarat. Tahap pengumpulan sampah 100% tidak memenuhi syarat. Tahap pengangkutan sampah 100% tidak memenuhi syarat. Sarana dan prasarana 100% tidak memenuhi syarat. Melakukan reduksi sampah dari sumbernya dengan membuat bank sampah untuk mendapatkan sampah yang bernilai ekonomis.
MANAJEMEN PEMBELAJARAN BAHASA ARAB UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA DI MADRASAH ALIYAH AL-AZIZIYAH PUTRA GUNUNG SARI
Authors: IZOMI M. SYAHRUL 
Published: June 2024

The aim of this research is to find out the management of Arabic language learning at Al-aziziyah high school son of Gunung Sari, to find out how students' learning motivation is in learning Arabic at Al-aziziyah high school son of Gunung Sari. The Research Method used is field research with a qualitative approach whose research (field research) is qualitative, therefore the journal that the author compiled uses a qualitative descriptive approach. Based on the results of the study, it shows that the management of Arabic language learning in Madrasah Aliyah Al-aziziyah putra Gunung sari is not optimal. Student learning motivation in Arabic language learning at Al-aziziyah high school putra Gunung sari and have not been motivated in learning Arabic even though thoroughly, judging from the learning process of students in the classroom students listen to the teacher who is explaining in front of the class, there is still less motivation to learn Arabic for students in the Al-aziziyah high school putra Gunung sari.
GAMBARAN TINGKAT PENGETAHUAN MASYARAKAT TENTANG SWAMEDIKASI OBAT ANALGESIK DI DUSUN PONDOK BUAK
Authors: OKTAVIANI NUR 
Published: June 2024

Self-medication is the behavior of self-administering drugs based on a diagnosis of experienced symptoms. As many as 103,860 or 35.2% out of 294,959 households store drugs for self-medication, and the most commonly experienced complaint leading to self-medication is pain. Pain can become a problem if it is not promptly treated, leading to prolonged illness and potential harm to the individual. The aim of this research is to describe the public's knowledge level regarding self-medication of analgesic drugs in Pondok Buak village. This research is quantitative descriptive. This study's sample comprises of 134 people from the community who had self-medicate with analgesic medicines and satisfied the inclusion and exclusion criteria. Purposive sampling was employed for sampling. Furthermore, the instrument used in this study was a questionnaire with 11 questions about the level of knowledge of analgesic drug self-medication, which was classified as good (75%-100%), sufficient (56%-75%), and insufficient (56%). Univariate analysis was used to analyse the data. According to the findings, 55% of respondents had a solid knowledge of self-medication, 19% had an adequate comprehension, and 26% showed an insufficient understanding. Finally, with 74 respondents (55%), the description of the public's awareness level regarding self-medication of analgesic medications in Pondok Buak Hamlet is in the good category
Nutrient Status Of The Soil Layers Of Rice Fields In Taratara Satu District, West Tomohon District Tomohon City
Authors: Kamagi Kamagi , Kumolontang Wiesje Junnieke Nathsuo , Sinolungan Meldi Tieneke Magdalena , Rondonuwu Jenny Jeanette 
Published: June 2024

Research in the field aims to determine the nutrient status condition in rice fields' soil layers. The things studied are N, P, K, C-organic, soil pH, and soil texture. The research is a survey method with a composite soil sampling technique at 0, 10, and 20 cm depth. Soil samples were taken at six different rice field points in the Taratara area. The nutrient status of N, P, K, and soil pH were analyzed using the Paddy Soil Test Kit (PUTS). C-organic using the Walkley and black method and for soil texture using the pipette method. The data from the analysis is then arranged in table form and explained descriptively. The research results from the six locations studied showed that: 1). N nutrient status is at low status; 2). P nutrient status is low, medium, and high; 3). K nutrient status is at medium and high status; 4). C – Organic nutrient status is at very low and low status and 5). Soil pH is slightly acidic and 6). Soil texture conditions are in the criteria of loam, silty loam, and silty clay loam.
Keywords: Nutrient Status, Paddy Soil Layers.
Abstrak
Penelitian dilakukan di lapangan bertujuan untuk mengetahui kondisi status hara yang ada di lapisan tanah sawah. Hal-hal yang diteliti adalah: N, P, K, C-organik, pH tanah dan tekstur tanah. Metode penelitian adalah metode survei dengan teknik pengambilan sampel tanah perlapisan tanah pada kedalaman 0, 10 dan 20 cm secara komposit. Sampel tanah diambil pada enam titik lahan sawah yang berbeda di wilayah Taratara. Status hara N, P, K dan pH tanah dianalisis menggunakan Perangkat Uji Tanah Sawah (PUTS). C-organik dengan metode Walkley and black dan untuk tekstur tanah dengan metode pipet. Data hasil analisis kemudian disusun dalam bentuk tabel kemudian dijelaskan secara deskriptif. Hasil penelitian dari enam lokasi yang diteliti diperoleh bahwa : 1). Status hara N berada pada status rendah; 2). Status hara P berada pada status rendah, sedang dan tinggi; 3). Status hara K berada pada status sedang dan tinggi; 4). Status hara C – Organik berada pada status sangat rendah dan rendah dan 5). pH tanah berada pada kondisi agak asam serta 6). Kondisi tekstur tanah berada pada kriteria lempung, lempung berdebu dan lempung liat berdebu.

Kata kunci : Status Hara, Lapisan Tanah Sawah
Evaluation of antibiofilm activity for siderophore produced from rhizospheric Acinetobacter baumannii against of some respiratory tracts bacteria
Authors: Amel Hussaein Mussa  , Rafal Moayad Abdul-Latif  
Published: June 2024

Siderophore was extracted from Acinetobacter baumannii isolated from rhizosphere reigion in Baghdad City . The results appeared the ability of isolate (Acinetobacter baumannii 5) to produce Siderophore with diameter of (15) mm and the condition for production was temperature reached 30 degrees, and the optimum pH was 7 . Purification of siderophore through : Ion exchange chromatography for purify more stable form as ferric-siderophore complex and final step through gel filtration. The activity of purified siderophore as antibacterial agent was tested against 13 different local clinical bacterial as follows (Klebsiella pneumoniae ,Pseudomonas aeruginosa ,Acinetobacter baumannii , Escherichia.coli ,Streptococcus pyogenes ,Staph. aureus ,Enterobacter cloacea, Enterobacter aerogenes ,Enterococcus faecalis ,Burkholderia cepacian ,Serratia fiaria ,S. marcescens ,Klebsiella oxytoca ) isolates at concentration 20 mg/ml of free iron siderophore and the results showed that highest activity of siderophore was reported on Streptococcus.pyogenes with inhibition zone (26)mm, and on Acinetobacter baumannii, Serratia.marcescens and Escherichia.coli the inhibition zone was (20)mm while the lowest effects were on Serratia. fiaria and Klebsiella .oxytoca with inhibition zone (16mm). As well as, the purified siderophore showed good activity as antibiofilm of pathogenic bacteria. The highest antiadhesive percentage was observed for Escherichia.coli by percentage 64.4%.
Apoyo Social y su Influencia en el Agotamiento de docentes de Instituciones Educativas Policiales
Authors: Gálvez Galarza Pilar 
Published: June 2024

Los profesionales están expuestos a nuevos retos debido a la alta competitividad y el aumento de la demanda de profesionales preparados para enfrentar las presiones propias de su profesión. El estudio tuvo como objetivo analizar la influencia del apoyo social en el agotamiento profesional en docentes de instituciones educativas policiales en Arequipa 2018. La investigación se realizó bajo un enfoque empírico deductivo, correspondiendo a un tipo de investigación no experimental, desarrollado bajo un diseño correlacional causal, la población está conformada por docentes del nivel inicial, primario y secundario de los colegios policiales. La técnica que se utilizó fue la encuesta, y dos cuestionarios centrados en el apoyo social y agotamiento profesional dirigido a docentes. Se concluye que el apoyo social influye en la presencia del agotamiento profesional en un 70,10% demostrado a través del coeficiente de determinación R2 = 0,701 es decir que la variabilidad del agotamiento profesional es explicada por la relación lineal del apoyo social mientras que el 31,5% de la variabilidad queda explicada por otros factores.
Case Series: EGFR and ROS-1 Co-Occurrence in Advanced Non–Small Cell Lung Cancer
Authors: Alfayea Turki , Salim Alaa A. , Alkaiyat Mohammad , Al-Rehaily Samah 
Published: June 2024

ABSTRACT
Non–small cell lung cancer (NSCLC) is a heterogeneous disease with diverse molecular alterations. Two of the most common genetic abnormalities found in advanced NSCLC are mutations in the epidermal growth factor receptor (EGFR) and rearrangements in the ROS proto-oncogene 1 (ROS-1). Although these two alterations are typically mutually exclusive, there have been reports of their co-occurrence in a small subset of NSCLC patients. The discovery of this comutation has recently become apparent due to the increased use of more sensitive whole genome sequencing. We share our experience with two cases of coexisting EGFR and ROS-1 alterations. The first case is a 60-year-old man diagnosed with advanced adenocarcinoma of the lung with metastasis to bone and left adrenal gland. The second case is a 49-year-old woman diagnosed with stage IV lung adenocarcinoma with metastasis to the contralateral lung and diffuse abdominal lymphadenopathy. The first case was treated with osimertinib, and currently has had a stable disease on this medication for more than 3 years. The second case had a short interval of stable disease on osimertinib; then she developed progressive disease with poor response to anti–ROS-1 therapy. We believe patients with advanced NSCLC may have a higher incidence of coalterations, especially in the areas of the world with higher EGFR mutations and in the era of higher usage of whole genome sequencing. The presence of comutations will allow for a good long-term response to anti-EGFR therapy. This highlights the importance of the use of next-generation sequencing whenever possible and considers variant allele frequency as a factor in directing the therapy. There are many other unanswered questions, such as the best treatment sequencing or even the combined targeted therapy approach. This case series may add some information to the current literature.
Faktor Risiko yang Mempengaruhi Kejadian Kehamilan Ektopik (Literature Review)
Authors: Rohmahtin Estu Sixzar 
Published: June 2024

Terjadinya kehamilan ektopik bisa dipicu oleh sel telur yang sudah dibuahi namun mengalami hambatan dalam perjalanan menuju ke endometrium, sehingga implantasi terjadi diluar endometrium. Kejadian kehamilan ektopik akan membawa risiko pada hasil konsepsi. Kehamilan ektopik merupakan salah satu keadaan yang dapat menjadi penyebab kematian maternal selama kehamilan pada minggu pertama. Kehamilan ektopik tidak dapat dicegah, namun faktor risikonya dapat dikurangi. Tujuan dari penelitian ini adalah untuk mengetahui faktor risiko yang mempengaruhi kejadian kehamilan ektopik melalui literature review. Metode: penelitian ini dilakukan dengan cara mereview beberapa artikel sesuai kriteria inklusi yang telah ditetapkan berdasarkan tema, lalu dilakukan pengulasan. Hasil: dari 12 artikel ditemukan faktor risiko meliputi riwayat penyakit radang panggul yang terdapat pada 5 artikel, riwayat aborsi terdapat pada 4 artikel, riwayat kehamilan ektopik terdapat pada 5 artikel, riwayat operasi dibahas pada 5 artikel, usia dan paritas terdapat pada 4 artikel, vaginal douching terdapat pada 1 artikel, penggunaan kontrasepsi darurat terdapat pada 2 artikel, dan infertilitas tuba terdapat pada 1 artikel. Faktor risiko kehamilan ektopik yang paling dominan adalah riwayat penyakit radang panggul dan riwayat kehamilan ektopik. Kejadian kehamilan ektopik sering terjadi pada wanita usia reproduksi dan wanita multipara. Simpulan dan saran: berdasarkan hasil penelitian faktor risiko yang paling dominan yang mempengaruhi kehamilan ektopik meliputi riwayat aborsi, riwayat penyakit radang panggul, riwayat kehamilan ektopik, riwayat operasi, usia dan paritas, vaginal douching, penggunaan kontrasepsi darurat, dan infertilitas tuba. Saran yang dapat disampaikan untuk mereview lebih dalam guna mengkaji secara lebih rinci faktor risiko yang mempengaruhi terjadinya kehamilan ektopik.
Hubungan usia menarche dan paritas dengan terjadinya menopause diwilayah kerja puskesmas kamal
Authors: Lutfiyah  , Ervi Husni  , Elfira Nurul Aini  , Kasiati  
Published: June 2024

Menopause adalah periode menstruasi spontan terakhir yang disebabkan oleh berhentinya fungsi ovarium secara permanen. Menarche adalah menstruasi yang dialami pertama kali oleh seorang perempuan. Paritas adalah jumlah anak yang pernah dilahirkan. Pada kenyataan dilapangan usia menopause dipengaruhi oeh usia menarche dan paritas.. Jenis penelitian yang digunakan adalah jenis penelitian analitik observasional dengan pendekatan cross ectional. Populasi terdiri dari 135 wanita menopause dan sampel diambil dengan teknik Simple random sampling sejumlah 101 responden. Variabel independennya adalah usia menarche dan paritas, sedangkan variabel dependen adalah menopause. Data dikumpulkan menggunakan kuesioner dan dianalisis menggunakan uji statistik chi square dengan nilai α < 0,05. Dari hasil penelitian didapatkan wanita menopause sebagian besar (60,4%) menarche usia 12-14 tahun, sebagian besar (71,3%) paritas 2-4 kali, dan sebagian besar (74,2%) menopause usia 40-52 tahun. Wanita yang menarchenya <12 tahun hampir setengahnya (33,3%) menopause lambat, yang menarche 12-14 tahun sebagian besar (70,7%) menopause normal dan yang menarchenya >14 tahun sebagian besar (57,1%) menopause lebih cepat. Wanita yang paritasnya <2 sebagian besar (71,4% ) menopause cepat, yang paritasnya 2-4 kali hampir seluruhnya (86,7%) menopause normal dan yang paritasnya >4 sebagian besar (58,3%) menopause lebih lambat. Dari Hasil analisis didapatkan P Value 0.000 < 0.05 yang berarti ada hubungan antara usia menarche dengan terjadinya menopause, selain itu juga didapatkan P Value 0.000 <0.05 yang berarti juga terdapat hubungan paritas dengan terjadinya menopause. Kesimpulan pada penelitian ini yaitu terdapat hubungan usia menarche dan paritas dengan terjadinya menopause. Diharapkan kepada peneliti selanjutnya untuk menambahkan faktor pemakain kontrasepsi yang berhubungan dengan terjadinya menopause