bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association Between High-Sensitivity C-Reactive Protein and Coronary Plaque Subtypes Assessed by 64-Slice Coronary Computed Tomography Angiography in an Asymptomatic Population
Authors: Rubin Jonathan , Chang Hyuk-Jae , Nasir Khurram , Blumenthal Roger S. , Blaha Michael J. , Choi Eue-Keun , Chang Sung-A. , Yoon Yeonyee E. , Chun Eun Ju , Choi Sang-il , Agatston Arthur S. , Rivera Juan J. 
Published: March 2011

Background—
Elevated levels of C-reactive protein (CRP) are associated with poor cardiovascular outcomes, even after accounting for traditional cardiovascular risk factors. We sought to analyze the relationship between levels of CRP and coronary plaque subtypes as assessed by coronary computed tomography angiography.

Methods and Results—

We evaluated 1004 asymptomatic South Korean subjects (mean age, 49±9.3 years) who underwent coronary computed tomography angiography as part of a health screening evaluation. We examined the association between increasing CRP levels and plaque subtypes using multivariable linear and logistic regression analysis. Coronary plaque was observed in 211 of 1004 individuals (21%). Subjects with high CRP (≥2 mg/L) had an increased prevalence of any plaque type (30.7% versus 16.7%
P
<0.001) and mixed calcified arterial plaque (MCAP) (19.3% versus 6.3%
P
<0.001) as compared with subjects with low-normal CRP. Multivariable logistic regression analysis demonstrated that elevated CRP predicted the presence of any MCAP (high versus low-normal CRP group; odds ratio, 2.81; 95% confidence interval, 1.62 to 4.89). When examining the multivariable logistic regression analysis between the presence of ≥2 plaques and CRP, subjects with high CRP were more likely to have MCAP than those with low-normal CRP levels (odds ratio, 3.78; 95% confidence interval, 1.49 to 9.55).

Conclusions
Elevated levels of CRP are associated with an increased prevalence of MCAP as assessed by coronary computed tomography angiography. Longitudinal studies will determine if the excess risk observed in persons with elevated CRP may be mediated, at least in part, by an increased burden of MCAP.
Cardiac Troponin T Measured by a Highly Sensitive Assay Predicts Coronary Heart Disease, Heart Failure, and Mortality in the Atherosclerosis Risk in Communities Study
Authors: Saunders Justin T. , Nambi Vijay , de Lemos James A. , Chambless Lloyd E. , Virani Salim S. , Boerwinkle Eric , Hoogeveen Ron C. , Liu Xiaoxi , Astor Brad C. , Mosley Thomas H. , Folsom Aaron R. , Heiss Gerardo , Coresh Josef , Ballantyne Christie M. 
Published: March 2011

Background—
We evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated with incident coronary heart disease (CHD), mortality, and hospitalization for heart failure (HF) in a general population of participants in the Atherosclerosis Risk in Communities (ARIC) Study.

Methods and Results—

Associations between increasing cTnT levels and CHD, mortality, and HF hospitalization were evaluated with Cox proportional hazards models adjusted for traditional CHD risk factors, kidney function, high-sensitivity C-reactive protein, and N-terminal pro–B-type natriuretic peptide in 9698 participants aged 54 to 74 years who at baseline were free from CHD and stroke (and HF in the HF analysis). Measurable cTnT levels (≥0.003 μg/L) were detected in 66.5% of individuals. In fully adjusted models, compared with participants with undetectable levels, those with cTnT levels in the highest category (≥0.014 μg/L; 7.4% of the ARIC population) had significantly increased risk for CHD (hazard ratio=2.29; 95% confidence interval, 1.81 to 2.89), fatal CHD (hazard ratio=7.59; 95% confidence interval, 3.78 to 15.25), total mortality (hazard ratio=3.96; 95% confidence interval, 3.21 to 4.88), and HF (hazard ratio=5.95; 95% confidence interval, 4.47 to 7.92). Even minimally elevated cTnT (≥0.003 μg/L) was associated with increased risk for mortality and HF (
P
<0.05). Adding cTnT to traditional risk factors improved risk prediction parameters; the improvements were similar to those with N-terminal pro–B-type natriuretic peptide and better than those with the addition of high-sensitivity C-reactive protein.

Conclusions—
cTnT detectable with a highly sensitive assay was associated with incident CHD, mortality, and HF in individuals from a general population without known CHD/stroke.
Percutaneous Vascular Stent Implantation as Treatment for Central Vascular Obstruction Due to Fibrosing Mediastinitis
Authors: Albers Erin L. , Pugh Meredith E. , Hill Kevin D. , Wang Li , Loyd James E. , Doyle Thomas P. 
Published: March 2011

Background—

Fibrosing Mediastinitis (FM) is a rare complication of infection with
Histoplasma capsulatum
that can lead to obstruction of pulmonary and systemic vasculature and large airways, often resulting in significant morbidity and mortality. Medical therapy is ineffective, and surgical intervention is often not feasible. Stent implantation offers a potential treatment for vascular obstruction due to FM, but this has not been well studied.

Methods and Results—

We conducted a retrospective review of all patients undergoing cardiac catheterization for FM. Anatomic site of stenosis and hemodynamic information before and after intervention, as well as clinical presentation and follow-up data, were recorded. From 1996 to 2008, 58 patients underwent cardiac catheterization for FM, with intervention performed in 40 (69%). A total of 77 stents were used to relieve 59 lesions (pulmonary artery=26, pulmonary vein=21, and superior vena cava=12). Significant reduction in pressure gradients (
P
<0.001) and increase in vessel caliber (
P
<0.001) were seen at all locations. Symptomatic recurrent stenosis requiring further intervention occurred in 11 patients (28%). Median time to recurrence was 115 months. Thirty-two (87%) of 37 patients for whom follow-up was available reported symptomatic improvement after stent placement. Procedure-related complications occurred in 14 patients (24%). Overall mortality was 19%, with the majority of deaths in patients with bilateral disease. Among patients with bilateral disease, intervention was associated with improved survival at 5 years.

Conclusion—
Percutaneous vascular stent implantation is an effective therapy for central vascular obstruction due to FM, providing significant relief of anatomic obstruction and sustained clinical improvement.
Pathological Healing Response of Explanted MitraClip Devices
Authors: Ladich Elena , Michaels Mary Beth , Jones Russell M. , McDermott Elizabeth , Coleman Leslie , Komtebedde Jan , Glower Donald , Argenziano Michael , Feldman Ted , Nakano Masataka , Virmani Renu 
Published: March 2011

Background—
The safety and effectiveness of the MitraClip device (Abbott Vascular, Menlo Park, CA) is being evaluated in the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) clinical studies. The healing response after device implantation has not previously been characterized in humans.

Methods and Results—

A total of 67 explanted devices (implantation duration, 1 to 1878 days) from 50 patients were submitted for histological evaluation. Explants were analyzed in 4 implantation intervals: acute (≤30 days; n=7), subacute (31 to 90 days; n=23), chronic (91 to 300 days; n=18), and long term (>300 days; n=19). The acute healing response consisted of platelet/fibrin deposition. The subacute response exhibited granulation tissue with early fibrous encapsulation (pannus). The chronic response was characterized by various degrees of tissue bridging between the device arms. The long-term healing response demonstrated collagen-rich matrix (by type I collagen), incorporating the device components with complete encapsulation by organized, fibrous growth. In long-term devices with minimal surgical disruption, a fibrous tissue bridge (mean area, 7.39±4.3 mm
2
) was observed over and between the device arms, resulting in atrial tissue continuity between the 2 valve leaflets. Devices demonstrated no evidence of endocarditis, mechanical wear, component fracture, or corrosion up to the time of explantation (median, 119 days; first and third quartiles, 42 and 365 days).

Conclusions—
In all patients, device mechanical integrity was maintained up to the time of explantation. Four phases of physiological healing were observed: platelet and fibrin deposition, inflammation, granulation tissue, and finally, fibrous encapsulation. Long-term device fibrous encapsulation with extension over adjacent mitral leaflets and tissue bridge formation adds structural stability.

Clinical Trial Registration—

URL:
http://clinicaltrials.gov/show/NCT00209274
. Unique identifiers: NCT00209339 and NCT00209274.
The Role of Moisture–Convection Feedbacks in Simulating the Madden–Julian Oscillation
Authors: Hannah Walter M. , Maloney Eric D. 
Published: March 2011

AbstractThe sensitivity of a simulated Madden–Julian oscillation (MJO) was investigated in the NCAR Community Atmosphere Model 3.1 with the relaxed Arakawa–Schubert convection scheme by analyzing the model’s response to varying the strength of two moisture sensitivity parameters. A higher value of either the minimum entrainment rate or rain evaporation fraction results in increased intraseasonal variability, a more coherent MJO, and enhanced moisture–convection feedbacks in the model. Changes to the mean state are inconsistent between the two methods. Increasing the minimum entrainment leads to a cooler and drier troposphere, whereas increasing the rain evaporation fraction causes warming and moistening. These results suggest that no straightforward correspondence exists between the MJO and the mean humidity, contrary to previous studies.Analysis of the mean column-integrated and normalized moist static energy (MSE) budget reveals a substantial reduction of gross moist stability (GMS) for increased minimum entrainment, while no significant changes are found for an increased evaporation fraction. However, when considering fluctuations of the normalized MSE budget terms during MJO events, both methods result in negative GMS prior to the deep convective phase of the MJO. Intraseasonal fluctuations of GMS, rather than the mean, appear to be a better diagnostic quantity for testing a model’s ability to produce an MJO.
The Interaction Between Deep Convection and Easterly Waves over Tropical North Africa: A Weather State Perspective
Authors: Mekonnen Ademe , Rossow William B. 
Published: March 2011

Abstract
The interaction between deep convection and easterly waves over tropical North Africa is studied using a weather state (WS) dataset from the International Cloud Climatology Project (ISCCP) and reanalysis products from the European Centre for Medium-Range Weather Forecast, as well as radiative fluxes from ISCCP and a precipitation dataset from the Global Precipitation Climatology Project. Composite analysis based on 21 yr of data shows that stronger latent and radiative heating of the atmosphere are associated with stronger, more organized, convective activity than with weaker, less organized, convective activity, implying that any transition from less to more organized and stronger convection increases atmospheric heating. Regression composites based on a meridional wind predictor reveal coherent westward propagation of WS and large-scale wind anomalies from the Arabian Sea into East Africa and through West Africa. The analysis shows that enhanced, but unorganized, convective activity, which develops over the Arabian Sea and western Indian Ocean, switches to organized convective activity prior to the appearance of the African easterly wave (AEW) signature. The results also suggest that low-level moisture flux convergence and the upper-tropospheric wind divergence facilitate this change. Thus, the upper-level easterly waves, propagating into East Africa from the Indian Ocean, enhance one form of convection, which interacts with the Ethiopian highlands to trigger another, more organized, form of convection that, in turn, initiates the low-level AEWs.
Effects of Tropical Cyclones on Ocean Heat Transport in a High-Resolution Coupled General Circulation Model
Authors: Scoccimarro Enrico , Gualdi Silvio , Bellucci Alessio , Sanna Antonella , Giuseppe Fogli Pier , Manzini Elisa , Vichi Marcello , Oddo Paolo , Navarra Antonio 
Published: March 2011

Abstract
In this paper the interplay between tropical cyclones (TCs) and the Northern Hemispheric ocean heat transport (OHT) is investigated. In particular, results from a numerical simulation of the twentieth-century and twenty-first-century climates, following the Intergovernmental Panel on Climate Change (IPCC) twentieth-century run (20C3M) and A1B scenario protocols, respectively, have been analyzed. The numerical simulations have been performed using a state-of-the-art global atmosphere–ocean–sea ice coupled general circulation model (CGCM) with relatively high-resolution (T159) in the atmosphere. The CGCM skill in reproducing a realistic TC climatology has been assessed by comparing the model results from the simulation of the twentieth century with available observations. The model simulates tropical cyclone–like vortices with many features similar to the observed TCs. Specifically, the simulated TCs exhibit realistic structure, geographical distribution, and interannual variability, indicating that the model is able to capture the basic mechanisms linking the TC activity with the large-scale circulation. The cooling of the surface ocean observed in correspondence of the TCs is well simulated by the model. TC activity is shown to significantly increase the poleward OHT out of the tropics and decrease the poleward OHT from the deep tropics on short time scales. This effect, investigated by looking at the 100 most intense Northern Hemisphere TCs, is strongly correlated with the TC-induced momentum flux at the ocean surface, where the winds associated with the TCs significantly weaken (strengthen) the trade winds in the 5°–18°N (18°–30°N) latitude belt. However, the induced perturbation does not impact the yearly averaged OHT. The frequency and intensity of the TCs appear to be substantially stationary through the entire 1950–2069 simulated period, as does the effect of the TCs on the OHT.
The prognostic value of triple negative in stage II/III breast cancer
Authors: Elnashar Afaf T , Ali El-Sayed M , Gaber Ahmed 
Published: March 2011

Introduction. Breast cancer is no longer seen as a single disease but rather a multifaceted disease composed of distinct biological subtypes with diverse natural history, clinical, pathological, and molecular features. Recent attention has been directed at the molecular classification of breast cancer. Objective. To evaluate the prognostic value of triple-negative subtype in stage II/III breast cancer and to define the role of clinical stage in prognosis of breast cancer. Methods. We used the immunohistochemical technique to divide 255 cases of breast cancer, stages II and III, into four subtypes according to estrogen receptor/progesterone receptor and Her-2 expression. Results. Triple-negative subtype comprised 76.5% of the cases with 12.3% recurrence rate. Luminal A subtype also carried a poor outcome with 16.7% recurrence rate. Conclusion. Triple-negative subtype has the worst overall and disease-free survival in stage II/III breast cancer. Clinical stage is still an independent prognostic factor in the breast cancers of all types.
Prediabetes influences cardiac rehabilitation in coronary artery disease patients
Authors: Russo Nicola , Compostella Leonida , Fadini Gianpaolo , Setzu Tiziana , Iliceto Sabino , Bellotto Fabio , Avogaro Angelo 
Published: March 2011

Background: An abnormal glucose tolerance (AGT) in coronary artery disease (CAD) patients could negatively influence recovery after an acute event but the question, relevant in the field of cardiac rehabilitation (CR), is still controversial. Design: Prospective study, aiming to establish the prevalence of AGT and its possible influence on functional recovery in CAD patients without a previous diagnosis of diabetes mellitus (DM). Methods: An oral glucose tolerance test was performed on 230 CAD patients without known DM, submitted to a 2-week period of intensive exercise-based CR after a recent acute myocardial infarction or coronary artery bypass graft. Functional capacity was assessed by a cardiopulmonary exercise test (CPET) and by 6-minute walking tests (6MWT) performed both on admission and at discharge. Results: The prevalence of AGT in our population was 53%. Exercise capacity was lower in AGT patients (maximum workload achieved at CPET 79.3 ± 29.9 vs. 91.8 ± 36.9 W, p = 0.01; peak-VO2 17.8 ± 4.7 vs. 19.8 ± 5.6 ml/kg/min, p = 0.01). In the subgroup of AGT patients characterized by an inferior walking capacity at baseline, the increment in the distance walked was less than in the controls (Δ6MWT: 81.9 ± 60.1 vs. 109.1 ± 72.1, p = 0.04). An independent, negative, association was observed between AGT and Δ6MWT in patients with lower baseline test, and between maximum workload and peak-VO2 in the whole population. Conclusions: A high prevalence of AGT was observed in a population of CAD patients without known DM after an acute coronary event. AGT is associated to a lower functional recovery, and to a reduced exercise capacity at the end of CR.
LAG-3, TGF-β, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L
Authors: Lucas Carrie L. , Workman Creg J. , Beyaz Semir , LoCascio Samuel , Zhao Guiling , Vignali Dario A. A. , Sykes Megan 
Published: March 2011

Abstract
Administration of a single dose of anti-CD40L mAb at the time of allogeneic BM transplantation tolerizes peripheral alloreactive T cells and permits establishment of mixed hematopoietic chimerism in mice. Once engrafted, mixed chimeras are systemically tolerant to donor Ags through a central deletion mechanism and will accept any donor organ indefinitely. We previously found that the PD-1/PD-L1 pathway is required for CD8 T-cell tolerance in this model. However, the cell population that must express PD-1 and the role of other inhibitory molecules were unknown. Here, we report that LAG-3 is required for long-term peripheral CD8 but not CD4 T-cell tolerance and that this requirement is CD8 cell-extrinsic. In contrast, adoptive transfer studies revealed a CD8 T cell–intrinsic requirement for CTLA4/B7.1/B7.2 and for PD-1 for CD8 T-cell tolerance induction. We also observed that both PD-L1 and PD-L2 are independently required on donor cells to achieve T-cell tolerance. Finally, we uncovered a requirement for TGF-β signaling into T cells to achieve peripheral CD8 but not CD4 T-cell tolerance in this in vivo system.
Identification of the earliest NK-cell precursor in the mouse BM
Authors: Carotta Sebastian , Pang Swee Heng Milon , Nutt Stephen L. , Belz Gabrielle T. 
Published: March 2011

AbstractNatural killer (NK) cells are generated in the bone marrow (BM) from lymphoid progenitors. Although several different maturation states of committed NK cells have been described, the initial stages of NK-cell differentiation from the common lymphoid progenitor are not well understood. Here we describe the identification of the earliest committed NK-cell precursors in the BM. These precursors, termed pre-pro NK cells, lack the expression of most canonical NK cell–specific surface markers but express the transcription factor inhibitor of DNA binding 2 and high levels of the IL-7 receptor. In vitro differentiation studies demonstrate that pre-pro NK cells are committed to NK-cell lineage and appear to be upstream of the previously identified NK-cell progenitor population.
Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
Authors: Herman Sarah E. M. , Gordon Amber L. , Hertlein Erin , Ramanunni Asha , Zhang Xiaoli , Jaglowski Samantha , Flynn Joseph , Jones Jeffrey , Blum Kristie A. , Buggy Joseph J. , Hamdy Ahmed , Johnson Amy J. , Byrd John C. 
Published: March 2011

AbstractB-cell receptor (BCR) signaling is aberrantly activated in chronic lymphocytic leukemia (CLL). Bruton tyrosine kinase (BTK) is essential to BCR signaling and in knockout mouse models its mutation has a relatively B cell–specific phenotype. Herein, we demonstrate that BTK protein and mRNA are significantly over expressed in CLL compared with normal B cells. Although BTK is not always constitutively active in CLL cells, BCR or CD40 signaling is accompanied by effective activation of this pathway. Using the irreversible BTK inhibitor PCI-32765, we demonstrate modest apoptosis in CLL cells that is greater than that observed in normal B cells. No influence of PCI-32765 on T-cell survival is observed. Treatment of CD40 or BCR activated CLL cells with PCI-32765 results in inhibition of BTK tyrosine phosphorylation and also effectively abrogates downstream survival pathways activated by this kinase including ERK1/2, PI3K, and NF-κB. In addition, PCI-32765 inhibits activation-induced proliferation of CLL cells in vitro, and effectively blocks survival signals provided externally to CLL cells from the microenvironment including soluble factors (CD40L, BAFF, IL-6, IL-4, and TNF-α), fibronectin engagement, and stromal cell contact. Based on these collective data, future efforts targeting BTK with the irreversible inhibitor PCI-32765 in clinical trials of CLL patients is warranted.
Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
Authors: Laenoi Watchara , Uddin Muhammad Jasim , Cinar Mehmet Ulas , Große-Brinkhaus Christine , Tesfaye Dawit , Jonas Elisabeth , Scholz Armin M , Tholen Ernst , Looft Christian , Wimmers Klaus , Phatsara Chirawath , Juengst Heinz , Sauerwein Helga , Mielenz Manfred , Schellander Karl 
Published: March 2011

AbstractBackgroundLeg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs.MethodsThree hundred and ten F2pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software.ResultsEleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level.ConclusionsOur results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs.