bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis and Testing of Trifluoromethyl‐Containing Phosphonate—Peptide Conjugates as Inhibitors of Serine Hydrolases.
Authors: Sokolova Nadezhda V. , Nenajdenko Valentine G. , Sokolov Vladimir B. , Serebryakova Olga G. , Makhaeva Galina F. 
Published: March 2012

AbstractThe compounds (II) and (III) are screened for their inhibitory activity towards acetylcholinesterase (AChE), butylcholinesterase (BChE), and carboxylesterase (CaE).
ChemInform Abstract: (R)‐[(2‐Oxo‐4‐thiazolidinyl)methyl]triphenylphosphonium Iodide: A Wittig Reagent for the Synthesis of Cystein‐Derived Alkenes.
Authors: Shaffer Christina J. , Fan RuLin , Lewis Michael D. , Kowalczyk James J. 
Published: March 2012

AbstractA synthesis of enantiopure cysteine‐derived phosphonium reagent (IV), amenable to the kg scale, is developed and its utilization in Wittig reactions is demonstrated.
ChemInform Abstract: C‐Quaternary Vinylglycinols by Metal‐Catalyzed Cyclization of Allylic Bistrichloroacetimidates.
Authors: Klimovica Kristine , Grigorjeva Liene , Maleckis Ansis , Popelis Juris , Jirgensons Aigars 
Published: March 2012

AbstractBistrichloroacetimidates (III) undergo highly regioselective cyclization in the presence of Pd or Lewis acid catalysts to give vinyloxazolines.
ChemInform Abstract: Total Synthesis and Bioactivity of the Marine Alkaloid Pityriacitrin and Some of Its Derivatives.
Authors: Zhang Puyong , Sun Xiaofei , Xu Bin , Bijian Krikor , Wan Shengbiao , Li Guigen , Alaoui‐Jamali Moulay , Jiang Tao 
Published: March 2012

AbstractA novel access to pityriacitrin (IIIa) and several of its analogues via modified Pictet—Spengler reaction is described.
ChemInform Abstract: One‐Pot Synthesis of 2‐Nitrooxyalkoxylated Inosine Analogues Using Cyclic Ether and Isoamyl Nitrite.
Authors: Sakakibara Norikazu , Komatsu Masahiro , Maruyama Tokumi 
Published: March 2012

AbstractFirst examples of 2‐nitrooxyalkoxylated nucleosides are obtained by using cyclic ethers and isoamyl nitride.
ChemInform Abstract: Two New Flavones from Uvaria macrophylla Roxb. var. microcarpa and Their Cytotoxic Activities.
Authors: Chen Zhong , Liu Xue‐Run , Liu Yan‐Li , Xu Qiong‐Ming , Yang Shi‐Lin 
Published: March 2012

AbstractMacrophyllain A (I) and B (II) are tested against A 549, SK‐MES‐1, and NCI‐446 lung carcinoma cells.
ChemInform Abstract: Influence of Protecting Groups on the Reactivity and Selectivity of Glycosylation: Chemistry of the 4,6‐O‐Benzylidene‐Protected Mannopuranosyl Donors and Related Species
Authors: Aubry Sylvain , Sasaki Kaname , Sharma Indrajeet , Crich David 
Published: March 2012

AbstractReview: 151 refs.
Synthesis and Characterization of Dendrimer‐Encapsulated Bimetallic Core‐Shell PdPt Nanoparticles
Authors: Li Guoping , Lu Wenting , Luo Yunjun , Xia Min , Chai Chunpeng , Wang Xiaoqing 
Published: March 2012

AbstractUsing a successive method, PAMAM dendrimer‐encapsulated bimetallic PdPt nanoparticles have been successfully prepared with core‐shell structures (Pd@Pt DENs). Evidenced by UV‐vis spectra, high resolution transmission electron microscopy, and X‐ray energy dispersive spectroscopy (EDS), the obtained Pd@Pt DENs are monodispersed and located inside the cavity of dendrimers, and they show a different structure from monometallic Pt or Pd and alloy PdPt DENs. The core‐shell structure of Pd@Pt DENs is further confirmed by infrared measurements with carbon monoxide (IR‐CO) probe. In order to prepare Pd@Pt DENs, a required Pd/Pt ratio of 1:2 is determined for the Pt shell to cover the Pd core completely. Finally, a mechanism for the formation of Pd@Pt DENs is proposed.
Synthesis, Spectral, Thermal and Biological Studies of Mn(II), Co(II), Ni(II) and Cu(II) Complexes with 1‐(((5‐Mercapto‐1H‐1,2,4‐triazol‐3‐yl)imino)‐methyl)naphthalene‐2‐ol
Authors: Issa Raafat Mostafa , Gaber Mohammed , Al‐Wakiel Nadia Abd‐Elhamed , Fathalla Shaimaa Kamal 
Published: March 2012

AbstractMn(II), Co(II), Ni(II) and Cu(II) complexes of 5‐mercapto‐1,2,4‐triazol‐3‐imine‐2′‐hydroxynaphthaline have been synthesized and characterized by elemental analysis, IR, 1H NMR, EI‐mass, UV‐Vis, and ESR (electron spin resonance) spectra, molar conductance, magnetic moment measurements, DC conductivity and thermogravimetric analysis. IR spectra confirm that the ligand molecule existed in both thione and thiole forms. The molar conductance values indicate the complexes are nonelectrolyte. The magnetic moment values of the complexes display paramagnetic behavior. All studies confirm the formation of an octahedral geometry for complex 1 and the other complexes have tetrahedral geometrical structures. The structures of the complexes have also been theoretically studied by using the molecular mechanic calculations by the hyperchem. 8.03 molecular modeling program which confirm the proposed structures. The Schiff‐base ligand and its metal complexes have also been screened for their antimicrobial activities.
Enhanced Electrochemical Capacitive Properties of Nickel‐Cobalt Oxide Nano‐flakes Materials
Authors: Kong Lingbin , Deng Li , Lang Junwei , Ji Xu , Luo Yongchun , Kang Long 
Published: March 2012

AbstractNickel‐cobalt oxide nano‐flakes materials are successfully synthesized by a facile chemical co‐precipitation method followed by a simple calcination process. The studies show that the as‐prepared nickel‐cobalt oxides with different Ni/Co ratio are composed of NiO and Co3O4 compounds. The Co0.56Ni0.44 oxide material, which exhibits a mesoporous structure with a narrow distribution of pore size from 2 to 7 nm, possesses markedly enhanced charge‐discharge properties at high current density compared with the pure NiO and pure Co3O4. The Co0.56Ni0.44 oxide electrode shows a specific capacitance value of 1227 F/g at 5 mA/cm2, which is nearly three times greater than that of the pure NiO electrode at the same current density.
Synthesis of Some New 1,4‐Dihydropyridine Derivatives through a Facile One‐pot Hantzsch Condensation Catalyzed by Triethylamine
Authors: Ghalem Wassima , Boulcina Raouf , Debache Abdelmadjid 
Published: March 2012

AbstractA facile and efficient synthesis of new 1,4‐dihydropyridine derivatives was reported via Hantzsch three‐component condensation reaction of aldehydes or formylphenylboronic acids, ethyl acetoacetate, and ammonium acetate in the presence of a catalytic amount of triethylamine under solvent‐free conditions. The method described here offers several advantages including high yields, short reaction times, and simple work‐up procedure.
A Supermolecule Assembled by Sodium Cation, Crown Ether and α‐Dawson Heteropolyanion
Authors: Zhu Linli , Lu Xiaoming 
Published: March 2012

AbstractThe supermolecular based on sodium molybdate(VI) and sulfate, dibenzo‐18‐crown‐6 was synthesized in acetonitrile and characterized by elemental analysis, IR, 1H NMR, single crystal X‐ray diffraction, indicating that it contains [S2Mo18O62]4+ and [Na(DB18C6)(H2O)]+, where each sodium ion is deviated from the plane defined by the oxygen atoms in the corresponding crown ether. The compound crystallizes in the monoclinic space group C2/c with a=3.29332(10) nm, b=1.90917(6) nm, c=2.63132(7) nm, β=121.6630(10)°, V=14081.8(7) nm3, Z=8, T=293(2) K, and R1 (wR2)=0.0177 (0.1525). The compound exhibits a novel organic‐inorganic structure, in which the crown ether‐sodium complexes are coordinated to the terminal oxygen atoms of Mo18O54 and the oxygen atoms of water molecule.
Syntheses, Structures, and Properties of Two Coordination Compounds of Pb(II) and Cd(II) with Quinoline‐8‐oxy‐acetate Acid
Authors: Liang Jiehui , Wei Qing , Qiao Chengfang , Xia Zhengqiang , Ye Gang , Chen Sanping 
Published: March 2012

AbstractQuinoline‐8‐oxy‐acetate acid (8‐qoacH) reacts with M(II) (M=Pb and Cd) to give rise to two coordination complexes [Pb(8‐qoac)2] (1) and [Cd(8‐qoac)(bdc)0.5(H2O)2] (2) under hydrothermal conditions. They are characterized by single‐crystal X‐ray diffraction, IR, elemental, thermal analyses and luminescent analysis. The Pb metal centers connect the 8‐qoac anions to form a 1D linear chain in 1. In 2, two symmetrical [Cd(8‐qoac)(H2O)2] are bridged by a 1,4‐bdc2− to generate a coordination unit [Cd(8‐qoac)(bdc)0.5(H2O)2], and all the units are further connected to a 2D supramolecular layer‐like structure via hydrogen bonds. TG analyses indicate that 1 exhibits higher thermostability than 2. Fluorescence spectrum of compound 2 in solid state shows strong fluorescence property.
Promotion on Nucleation and Aggregation of Calcium Oxalate Crystals by Injured African Green Monkey Renal Epithelial Cells
Authors: Zhang Shen , Peng Hua , Yao Xiuqiong , Su Zexuan , Ouyang Jianming 
Published: March 2012

AbstractThe purpose of this work was to detect the properties of African green monkey renal epithelial cells (Vero) after oxidative injury and to study the mediation of the injured Vero on aggregation and formation of calcium oxalate crystals. This injury model was induced by 0.15 mmol/L H2O2 according to the pretest evaluation. The results suggested that H2O2 could injure Vero significantly and decrease cell viability in a time‐dependent manner for exposure time of 0.5–2 h. After cell injury, the indexes connected with oxidative injury changed. The malondialdehyde (MDA) content and osteopontin (OPN) expression increased, while superoxide dismutase (SOD) level decreased. It resulted in the increase of both the amount of CaOxa crystals and the degree of crystal aggregation on the injured cells. This work indicated that injured cells promoted the formation of calcium oxalate monohydrate (COM) crystals, thus increased the risk of formation of urinary stone.
Optimized Palladium(0)‐catalyzed Suzuki Cross‐coupling Reaction of Polystyrene‐supported Selenenyl Flavanones: A Convenient Preparation of Biaryl‐chromen‐4‐one
Authors: Tang E , Li Wen , Gao Zhangyong , Zhang Lianpeng , Ma Qiushi 
Published: March 2012

AbstractApplication of the Suzuki cross‐coupling reaction for efficient synthesis of diverse substituted biaryl‐chromen‐4‐ones using an optimized palladium(0) catalyst system is reported. The coupling of arylboronic acids with the resin‐bound bromoflavanones which were prepared by organoselenium‐induced regioselective intramolecular cyclization of bromo‐2‐hydroxylchalcones proceeded smoothly. Biaryl‐chromen‐4‐ones were synthesized by subsequent selenoxide syn‐elimination in good total yields.
Eine „bärchenstarke“ Reduktion
Authors: Herriger Cornelia , Schmitz Wolfgang , Zajonc Stefan , Ducci Matthias 
Published: March 2012

AbstractAusgehend von faszinierenden Experimenten mit Gummibärchen wird im vorliegenden Beitrag ein Konzept vorgestellt, mit dem der Themenkreis „Reduktion von Azofarbstoffen“ anhand zahlreicher Experimente von Schülerinnen und Schülern im Rahmen eines angeleiteten forschenden Unterrichts erschlossen werden kann.
Frischer Wind beim Experimentieren
Authors: Hadenfeldt Jan Christoph , Neumann Knut 
Published: March 2012

AbstractExperimentierkästen sollen Schülerinnen und Schülern die Möglichkeit bieten, ohne fachkundige Aufsicht naturwissenschaftliche Fragestellungen zu bearbeiten. Die beiliegenden Experimentieranleitungen sollen sie dabei begleiten – im Idealfall ohne rezeptartig durch die Experimente zu leiten. Im Rahmen des im vorliegenden Beitrag vorgestellten Projekts haben Schülerinnen und Schüler der Oberstufe handelsübliche Experimentierkästen und Experimentieranleitungen daraufhin untersucht, inwieweit dieser Spagat gelingt.
Total Synthesis of Isoprostanes Derived from Adrenic Acid and EPA
Authors: Oger Camille , Bultel‐Poncé Valérie , Guy Alexandre , Durand Thierry , Galano Jean‐Marie 
Published: March 2012

AbstractEnantiomerically enriched F2‐dihomo‐isoprostanes and F3‐isoprostanes have been synthesized. Such compounds are derived from the action of reactive oxygen species on the phospholipid‐bound polyunsaturated fatty acids (PUFA), adrenic acid and eicosapentaenoic acid, respectively. Of special interest are the F2‐dihomo‐isoprostanes because they could represent potential biomarkers for myelin damage as its main PUFA constituent is adrenic acid. Our strategy, based on a pivotal enantiomerically enriched intermediate, has allowed access to F2‐dihomo‐IsoP and both C5 epimers of 5‐F3t‐IsoP for the first time.
Determination of Blasticidin S in Spiked Rice Using SW Voltammetry with a Renewable Silver Amalgam Film Electrode
Authors: Skrzypek Slawomira , Smarzewska Sylwia , Ciesielski Witold 
Published: March 2012

AbstractBlasticidin S (BS) was determined in spiked rice samples by square wave voltammetry (SWV) and square wave stripping voltammetry (SWSV) using a cyclic renewable silver amalgam film electrode (Hg(Ag)FE). It was found that the compound can act as an electrocatalyst. In BrittonRobinson buffer at pH 7.0 a signal connected with the hydrogen evolution reaction was detected at −1.2 V versus Ag/AgCl. Validation of the method was carried out. The detection and quantification limits were found to be 2.13×10−8 mol L−1; 7.10×10−8 mol L−1 for SWV and 2.65×10−9 mol L−1; 8.85×10−9 mol L−1 for SWSV, respectively.
Oxidation of DNA Bases Influenced by the Presence of Other Bases
Authors: Shuhua Goh Madeline , Pumera Martin 
Published: March 2012

AbstractElectrochemical detection of DNA is a highly important topic. Here we show that the electrochemical responses of one DNA base (guanine, adenine, cytosine or thymine), in terms of oxidation potential, current intensity, peak width and resolution can be highly influenced by the presence of other DNA bases at electrochemically reduced graphene oxide (ER‐GO) as well as standard glassy carbon electrode. We have observed that the effects were more significant for adenine base on ER‐GO and cytosine base on glassy carbon (GC) electrode. Differences in responses were generally low in a mixture of four different DNA bases but interestingly, deviations become significantly larger when only one or two other bases were present. Our findings are of paramount importance for future developments in DNA detection and analysis since individual DNA bases are not present in isolation in nature or in typical biosensing systems.
Conditional simulation of spatially variable seismic ground motions based on evolutionary spectra
Authors: Hu L. , Xu Y. L. , Zheng Y. 
Published: March 2012

SUMMARYThis paper proposes a computational procedure for the conditional simulation of spatially variable seismic ground motions for long span bridges with multiple supports. The seismic ground motions, with part of their time histories measured at some supports, are regarded as zero‐mean nonstationary random processes characterized by predefined evolutionary power spectral density. To conditionally simulate unknown seismic ground motion time histories at other supports, the Kriging method is first described briefly for the conditional simulation of a random vector comprised of zero‐mean Gaussian variables. The multivariate oscillatory processes characterized by the evolutionary power spectral density matrix are then introduced, and the Fourier coefficients of the oscillatory processes and their covariance matrix are derived. By applying the Kriging method to the random vector of the Fourier coefficients and using the inverse Fourier transform, unknown nonstationary seismic ground motion time histories can be simulated. A numerical example is selected to demonstrate capabilities of the proposed simulation procedure, and the results show that the procedure can ensure unbiased time‐varying correlation functions, especially the cross correlation between known and unknown time histories. The procedure is finally applied to the Tsing Ma suspension bridge in Hong Kong to generate ground accelerations at its multiple supports using limited seismic records. Copyright © 2012 John Wiley & Sons, Ltd.
Achievable rate region for the Gaussian MIMO MAC with cooperating encoders
Authors: Fraidenraich Gustavo , Portugheis Jaime 
Published: March 2012

ABSTRACTThis paper considers a Gaussian two‐user multiple‐input multiple‐output (MIMO) multiple access channel (MAC) with cooperating encoders. After defining a form of cooperation strategy, we derive achievable rate bounds by applying the results obtained by Willems for the MAC with generalised feedback. Then, we characterise an achievable rate region and also provide a lower bound for this region, which are very close. Although the achievable rate bounds are described by non‐concave functions, the boundary of the achievable rate region could be generated by maximising a weighted sum of the rates. Numerical results obtained generally exceed the capacity region of a MIMO MAC without cooperation. Copyright © 2012 John Wiley & Sons, Ltd.
Lagranges “récherches sur la libration de la lune”
Authors: Bremer Hartmut 
Published: March 2012

AbstractAus der Vielzahl der erfolgreichen Beiträge des achtzehnten Jahrhunderts beinhaltet der erste Beitrag Lagranges über die Mondbewegungen einen Durchbruch für die analytische Mechanik. Obgleich seine ureigenste Leistung, steht Lagranges dabei natürlich nicht isoliert da: Aufbauend auf den Ergebnissen früherer und in engem Kontakt mit zeitgenössischen Wissenschaftlern konnte er derart bahnbrechende Leistungen erzielen, eingebettet in die kulturell–philosophische Umwelt der Zeit. Hinter allen mit Namen versehenen Formeln stehen, auch in der heute dominanten Computer‐Programmwelt, denkende und fühlende Menschen, dessen wir uns, die wir – auch als “Anwender” – in der Traditionskette unserer wissenschaftlichen Ahnen stehen, sehr bewußt sein sollten.Die historischen Hintergründe sind aber nicht nur spannend, sondern bieten durchaus auch reellen Nutzen: “So oft ich mich mit den grundlegenden Arbeiten unserer großen Meister unmittelbar vertraut machte, hatte ich einen Gewinn an Einsicht und Verständnis zu verzeichnen, der weit über das hinausging, was aus den sekundären Quellen zu entnehmen war”, Wilhelm Ostwald (1855–1932).Die früher oft sehr mühsame Beschaffung der Quellen ist durch das Internet bequem geworden. Diejenigen Unterlagen, die dem Autor nicht direkt in Papierform zu Verfügung standen, sind im Literaturverzeichnis mit ihrer Internetadresse angegeben. Dies möge den Leser zum “Schmökern” anreizen (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Phonological processing in first‐degree relatives of individuals with autism: An fMRI study
Authors: Wilson Lisa B. , Tregellas Jason R. , Slason Erin , Pasko Bryce E. , Hepburn Susan , Rojas Donald C. 
Published: March 2012

AbstractAutism spectrum disorders (ASD) are complex neurodevelopmental disorders. Twin studies have provided heritability estimates as high as 90% for idiopathic ASD. Further evidence for the spectrum's heritability is provided by the presence of the broad autism phenotype (BAP) in unaffected first‐degree relatives. Language ability, specifically phonological processing, is proposed to be a core BAP trait. To date, however, no functional neuroimaging investigations of phonological processing in relatives of individuals with ASD have been undertaken. We conducted a functional magnetic resonance imaging (fMRI) study in parents of children with ASD utilizing a priming task probing implicit phonological processing. In our condition that placed heavier demands on phonological recoding, parents exhibited greater hemodynamic responses than controls in a network of cortical regions involved in phonological processing. Across conditions, parents exhibited enhanced priming‐induced response suppression suggesting compensatory neural processing. A nonword repetition test used in previous studies of relatives was also administered. Correlations between this measure and our functional measures also suggested compensatory processing in parents. Regions exhibiting atypical responses in parents included regions previously implicated in the spectrum's language impairments and found to exhibit structural abnormalities in a parent study. These results suggest a possible neurobiological substrate of the phonological deficits proposed to be a core BAP trait. However, these results should be considered preliminary. No previous fMRI study has investigated phonological processing in ASD, so replication is required. Furthermore, interpretation of our fMRI results is limited by the fact that the parent group failed to exhibit behavioral evidence of phonological impairments. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
Systematic analysis of genotype‐specific drug responses in cancer
Authors: Kim Nayoung , He Ningning , Kim Changsik , Zhang Fan , Lu Yiling , Yu Qinghua , Stemke‐Hale Katherine , Greshock Joel , Wooster Richard , Yoon Sukjoon , Mills Gordon B 
Published: March 2012

AbstractA systematic understanding of genotype‐specific sensitivity or resistance to anticancer agents is required to provide improved patient therapy. The availability of an expansive panel of annotated cancer cell lines enables comparative surveys of associations between genotypes and compounds of various target classes. Thus, one can better predict the optimal treatment for a specific tumor. Here, we present a statistical framework, cell line enrichment analysis (CLEA), to associate the response of anticancer agents with major cancer genotypes. Multilevel omics data, including transcriptome, proteome and phosphatome data, were integrated with drug data based on the genotypic classification of cancer cell lines. The results reproduced known patterns of compound sensitivity associated with particular genotypes. In addition, this approach reveals multiple unexpected associations between compounds and mutational genotypes. The mutational genotypes led to unique protein activation and gene expression signatures, which provided a mechanistic understanding of their functional effects. Furthermore, CLEA maps revealed interconnections between TP53 mutations and other mutations in the context of drug responses. The TP53 mutational status appears to play a dominant role in determining clustering patterns of gene and protein expression profiles for major cancer genotypes. This study provides a framework for the integrative analysis of mutations, drug responses and omics data in cancers.
HMG CoA reductase inhibitors, NSAIDs and risk of glioma
Authors: Ferris Jennifer S. , McCoy Lucie , Neugut Alfred I , Wrensch Margaret , Lai Rose 
Published: March 2012

Abstract3‐Hydroxy‐3‐methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) have shown inverse associations with cancer risks, but the results have been inconsistent. As there are no previous published data in brain tumors, we conducted a case–control study to investigate statin therapy and risk of glioma. We further evaluated the use of nonsteriodal anti‐inflammatory drugs (NSAIDs) and risk of these tumors. We recruited newly diagnosed glioma cases and frequency matched controls at Columbia University and the University of California San Francisco. Standardized questions on statins and NSAIDs were used at both institutions. Intakes of these drugs were defined as >6 months of at least twice weekly use versus less than this amount or never use. From July 2007 to January 2010, we recruited a total of 517 cases and 400 controls. Simvastatin and lovastatin showed significant inverse associations with glioma (odds ratio [OR] = 0.49, 95% confidence interval [CI] 0.30, 0.81 and OR = 0.47, 95% CI 0.24, 0.93, respectively). For NSAIDs, aspirin use was also inversely related to glioma risk (OR = 0.68, 95% CI 0.49, 0.96). Both statins and NSAIDs showed significant inverse trends between the duration of drug use and glioma risk (trend tests p = 0.03 and p = 0.02, respectively), and drug intake for >120 months demonstrated the most significant associations for both types of medication. The inverse association between statin therapy and risk of glioma supports the roles of Ras/Rho GTPases or inflammatory cytokines in gliomagenesis, and a similar relationship between NSAIDs and glioma highlights the importance of cyclo‐oxygenase 2 in glioma pathogenesis.