bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between overactive bladder and fibromyalgia syndrome: A community survey
Authors: Chung Jae Hoon , Kim Shin Ah , Choi Bo Youl , Lee Hye‐Soon , Lee Seung Wook , Kim Yong Tae , Lee Tchun Yong , Moon Hong Sang 
Published: June 2012

AbstractAimsFibromyalgia syndrome (FMS) is the most common disease causing chronic generalized pain, and FMS patients often complain of urinary symptoms such as frequency or urgency. This study focuses on the association of overactive bladder (OAB) and FMS in adults aged 40 and over.MethodsA survey of adults aged 40s and over was conducted in the Guri and Yangpyeong areas of South Korea. The response rate was 74.2% (940/1,266). After excluding subjects with incomplete questionnaires (n = 20), 920 were included in the final analysis. The association of FMS and OAB was analyzed by univariate and multivariate logistic regression analysis.ResultsIndividuals with FMS had a significantly increased symptoms of OAB after adjustment for gender, age group, and area of residence (odds ratio (OR) 3.39, 95% confidence interval (CI) 1.82–6.31). The association between FMS and severity of OAB was statistical significant (P for trend <0.0001).ConclusionsOAB is associated with FMS. Moreover FMS increases with severity of OAB. Neurourol. Urodynam. 32: 66–69, 2013. © 2012 Wiley Periodicals, Inc.
Pudendal neuromodulation improves voiding efficiency in diabetic rats
Authors: Chen Shih‐Ching , Lai Chien‐Hung , Fan Wen‐Jia , Peng Chih‐Wei 
Published: June 2012

AbstractAimsDiabetic cystopathy is typically manifested as bladder voiding dysfunction, and numerous patients are refractory to standard therapy. In this study, we determined whether electrical stimulation (ES) of the sensory branch of the pudendal nerve could engage an augmenting reflex and thereby improve bladder emptying in a diabetic animal model with cystopathy.MethodsThe efficiency of bladder emptying with ES of the sensory branch of the pudendal nerve at different stimulation intensities was measured in rats at 8 or 18 weeks after the induction of diabetes with streptozotocin.ResultsThe voiding efficiency (VE) was reduced from 74 ± 4% to 30 ± 8% in rats with diabetes for 8 weeks and from 73 ± 6% to 20 ± 6% in rats with diabetes for 18 weeks. ES at lower intensities (0.025–0.05 mA) applied to the pudendal sensory nerve did not affect the VE in rats with diabetes for 18 weeks but increased the VE in rats with diabetes for 8 weeks. Subsequently, when the stimulation intensity was elevated to 0.1–0.3 mA, the VEs in rats with diabetes for both 8 and 18 weeks increased to 40–50%.ConclusionsThe results of the present study are consistent with the essential role for pudendal sensory feedback in efficient bladder emptying, and electrical activation of the sensory branch of the pudendal nerve was efficient restoring the voiding function in diabetic animals with cystopathy. This could provide an approach to improve bladder emptying in diabetic patients with voiding dysfunction. Neurourol. Urodynam. 32: 293–300, 2013. © 2012 Wiley Periodicals, Inc.
Static, free vibration, and buckling analysis of laminated composite Reissner–Mindlin plates using NURBS‐based isogeometric approach
Authors: Thai Chien H. , Nguyen‐Xuan H. , Nguyen‐Thanh N. , Le T‐H. , Nguyen‐Thoi T. , Rabczuk T. 
Published: June 2012

SUMMARYThis paper presents a novel numerical procedure based on the framework of isogeometric analysis for static, free vibration, and buckling analysis of laminated composite plates using the first‐order shear deformation theory. The isogeometric approach utilizes non‐uniform rational B‐splines to implement for the quadratic, cubic, and quartic elements. Shear locking problem still exists in the stiffness formulation, and hence, it can be significantly alleviated by a stabilization technique. Several numerical examples are presented to show the performance of the method, and the results obtained are compared with other available ones. Copyright © 2012 John Wiley & Sons, Ltd.
Unilever's strategic response to sustainable development and its implications for public affairs professionals
Authors: Lingard Thomas 
Published: June 2012

Unilever is often cited as one of the organisations that is most sophisticated in thinking about and responding strategically to the range of global trends we tend to put under the heading ‘sustainable development’. This paper explores the rationale in Unilever for doing this and looks at the implications it has for Public Affairs. Taking a step back from this and thinking about the historical role of the public affairs professional, and about what Unilever and others are beginning to do, the changing role of the public affairs professional is discussed.In this article, Thomas Lingard talks to JPA SI guest editor Matthew Gitsham. Copyright © 2012 John Wiley & Sons, Ltd.
Dynamic viscoelasticity behaviors of magnesium dimethacrylate/natural rubber composites with different cure extent
Authors: Xu Chuanhui , Chen Yukun , Cao Liming , Zeng Xingrong 
Published: June 2012

AbstractIn this article, the dynamic viscoelasticity characteristics of the natural rubber (NR)/magnesium dimethacrylate (MDMA) composites with different cure extent are investigated using a Rubber Process Analyzer 2000 (RPA2000). A weak filler–filler network of MDMA is formed in the uncured compounds. MDMA polymerize during peroxide curing and change to the polymerized MDMA (PMDMA), which can aggregate to form strong filler network in the lightly cured composite. The ionic crosslinks and NR crosslinks influence the dynamic viscoelasticity characteristics of the MDMA/NR composites with different cure extent significantly. Although the PMDMA aggregates have strong attraction with each other to form filler network, the ionic crosslinks are not favorable to rebuild the PMDMA network when the NR crosslink network is mature. Finally, the torque verifies that the ionic crosslinks can be influenced by small strain magnitudes (<0.1°) whereas the NR crosslink network is not influenced. POLYM. COMPOS., 2012. © 2012 Society of Plastics Engineers
Use of magnetic resonance imaging in prenatal prognosis of the fetus with isolated left congenital diaphragmatic hernia
Authors: Victoria Teresa , Bebbington Michael W. , Danzer Enrico , Flake Alan W. , Johnson Mark P. , Dinan David , Adzick N. Scott , Hedrick Holly L. 
Published: June 2012

ABSTRACTObjectivesTo investigate the prognostic value of magnetic resonance‐calculated fetal lung volumes (FLV) in fetuses with isolated left congenital diaphragmatic hernia (L‐CDH) who receive standardized prenatal and postnatal care at a single institution.Materials and methodsA retrospective review was undertaken to identify fetuses with isolated L‐CDH between 2001 and 2010.ResultsEighty‐five cases of isolated L‐CDH were identified. The overall survival was 65% (55/85). Survival was 45% if there was ‘liver up’ (23/51) and 94% if there was ‘liver down’ (32/34). Univariate statistical analysis showed that ‘liver up’ (p = 0.001), lung‐to‐head ratio (LHR) at diagnosis (p = 0.009), observed/expected (O/E) LHR (p = 0.01), total FLV (p = 0.03), right LV (p = 0.04), magnetic resonance imaging (MRI) observed versus expected (O/E) FLV (p = 0.002), intrathoracic versus intraabdominal stomach (p = 0.002), percentage of herniated liver (p = 0.004), and postnatal extracorporeal membrane oxygenation use (p = 0.001) are predictive of postnatal survival. Multivariate analysis of only prenatal factors showed that the most important determinants of postnatal outcome are percentage of herniated liver, presence of liver up, and MRI O/E FLV.ConclusionHerniated intrathoracic liver expressed as ‘liver up’ or as percent herniated liver and MRI measurement of FLV expressed as a O/E ratio are strong prenatal indicators of postnatal survival. © 2012 John Wiley & Sons, Ltd.
Avalanche breakdown in multicrystalline solar cells due to preferred phosphorous diffusion at extended defects
Authors: Bauer Jan , Lausch Dominik , Blumtritt Horst , Zakharov Nikolai , Breitenstein Otwin 
Published: June 2012

ABSTRACTMulticrystalline solar cells break down strongly at reverse voltages well below the theoretical limit. Previous explanations were based on assuming a constant depth of the junction below the surface. In this work, preferred phosphorous diffusion at special line defects in grain boundaries is shown to lead to spikes in the p–n junctions even below flat surfaces. The curvature radii of the spherical p–n junction bending are measured by electron beam‐induced current to be in the range of 300–500 nm, leading to the observed type III avalanche breakdown voltages. Copyright © 2012 John Wiley & Sons, Ltd.
Rational basis for the combination of PCA3 and TMPRSS2:ERG gene fusion for prostate cancer diagnosis
Authors: Robert Grégoire , Jannink Sander , Smit Frank , Aalders Tilly , Hessels Daphne , Cremers Ruben , Mulders Peter F. , Schalken Jack A. 
Published: June 2012

AbstractBACKGROUNDThe prostate cancer gene 3 (PCA3) and TMPRSS2:ERG gene fusion are promising prostate cancer (PCa) specific biomarkers. Our aim was to simultaneously quantify the expression levels of PCA3 and TMPRSS2:ERG in a panel of benign prostatic hyperplasia (BPH), normal prostate adjacent to PCa (NP) and PCa tissue samples, to provide a rational basis for the understanding of the false‐positive and false‐negative results of the urine assays.METHODSThe tissue samples were carefully histopathologically characterized to obtain homogeneous groups. The mRNA was isolated, transcribed into cDNA and the relative expressions of PCA3 and TMPRSS2:ERG were measured using a quantitative real‐time polymerase chain reaction. The expression levels of PCA3 and TMPRSS2:ERG were compared between the different groups.RESULTSWe included 48 BPH, 32 NP, and 48 PCa. The PCA3 expression levels progressively increased from BPH to NP (3 times) and finally to PCa (30 times). There were one false‐positive sample and seven false‐negative samples. The TMPRSS2:ERG gene fusion was found in 8.3% of the BPH, 15.6% of the NP, and 50% of the PCa samples. The use of TMPRSS2:ERG in the PCA3 negative cases allowed diagnosis of four of the seven false‐negative samples and added one false‐positive, but we had to define a cut‐off value to avoid eight false‐positive results.CONCLUSIONSConsidering tissue expression of the markers, most of the false‐negative results of the PCA3 test were corrected by TMPRSS2:ERG (57%) and the combination of both had a higher sensitivity for PCa diagnosis. Some of the control samples did express TMPRSS2:ERG and a cut‐off value had to be defined to avoid false‐positive results. Prostate 73: 113–120, 2013. © 2012 Wiley Periodicals, Inc.
Global and local quantitative structure–property relationship models to predict the impact sensitivity of nitro compounds
Authors: Fayet Guillaume , Rotureau Patricia , Prana Vinca , Adamo Carlo 
Published: June 2012

AbstractNew quantitative structure–property relationships were developed to predict accurately the impact sensitivity of nitro compounds from their molecular structures. Such predictive approaches represent good alternative to complete experimental testing in development process or for regulatory issues (e.g., within the European REACH regulation).To achieve highly predictive models, two approaches were used to explore the whole diversity of nitro compounds included in a dataset of 161 molecules. In the first step, local models, dedicated to nitramines, nitroaliphatics, and nitroaromatics, were proposed. After that, a global model was developed to be applicable for the whole range of the nitro compounds of the dataset.In both cases, large series of molecular descriptors were calculated from quantum chemically calculated molecular structures, and multilinear regressions were computed to correlate them with experimental impact sensitivities. Both the global and local models could predict nitramines and nitroaliphatics in high accuracy whereas nitroaromatics were more difficult to be predicted due to their complex decomposition mechanisms.The proposed models were validated in the perspective of potential regulatory use according to the OECD principles, including internal, external validation, and the definition of their applicability domain. So, they could then be used for prediction either separately or in a consensus approach. © 2012 American Institute of Chemical Engineers Process Saf Prog, 2012
Low‐temperature synthesis of single‐domain Sr‐hexaferrite particles by solid‐state reaction route
Authors: Sözeri Hüseyin , Baykal Abdülhadi , Ünal Bayram 
Published: June 2012

AbstractSr‐hexaferrite particles have been synthesized by conventional solid‐state reaction route at low temperatures by boron addition that is used as an inhibitor for crystal growth. The effect of boron concentration on the structural, magnetic and electrical properties of Sr‐hexaferrite particles are investigated by X‐ray crystallography, scanning electron microscopy, magnetization and conductivity measurements. Saturation magnetization of Sr‐hexaferrite increases up to 1 wt% boron addition, while coercivity becomes maximum with a boron amount of 2 wt%. Then, both magnetic parameters start to decrease with higher boron concentrations. Single‐domain and single‐phase powders have been obtained in the sample containing 1 wt% of boron that is sintered at 1050 °C. Impedance spectroscopies reveal that the dc conductivity increases tremendously with boron addition, while the ac conductivity increases with elevated temperature. The ac conductivity obeys roughly the power law of angular frequency in which tendencies change with temperature at low and medium temperature. Furthermore, higher contents of the dopant over approximately 2.0 wt% cause its temperature independency at higher frequencies. These are due to the grain size and secondary phase of hexaferrites that increases with the increase in boron amount.
Polybenzimidazole‐decorated carbon nanotube: A high‐performance proton conductor
Authors: Majedi Fatemeh Sadat , Hasani‐Sadrabadi Mohammad Mahdi , Dashtimoghadam Erfan , Haghighi Amir Hossein , Bertsch Arnaud , Moaddel Homayoun , Renaud Philippe 
Published: June 2012

AbstractInteraction between negatively charged Nafion® and a positively charged polybenzimidazole‐decorated carbon nanotube leads to the formation of an ionic complex with high charge density for proton conduction, which can lead to an improvement in transport properties. Here we investigate the high‐temperature and low‐humidity proton conductivity of this nanocomposite membrane as a potential membrane for fuel cell applications.magnified image(© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Hydrogen bonds between acetylene and formic acid: An ab initio study
Authors: Belarmino M. K. D. L. , Lima N. B. D. , Ramos M. N. 
Published: June 2012

AbstractTheoretical calculations using both the second‐order Møller–Plesset and B3LYP levels of calculation with the 6‐31++G(d,p) and 6‐311++G(3df,3pd) basis sets were performed to determine stable structures, binding energies, and molecular properties for the H‐bonded complexes involving acetylene and formic acid. Three complexes were characterized as minima because no imaginary frequency was found. The calculations indicate that the most stable complex presents two H‐bonds forming a quasi‐cyclic structure. As expected, the HO stretching frequency of the formic acid is shifted downward after complexation, whereas its IR intensity is enormously increased. Finally, we have also studied the R1C2HHOOCR2 H‐bonded complexes with R1 and R2CH3 and C6H5 to compare their binding energies with that obtained to the HCOOHC2H2 complex. In this procedure, we have considered the most stable structure obtained to this latter using the B3LYP theoretical calculations with the 6‐31++G(d,p) basis set. © 2012 Wiley Periodicals, Inc.
Beyond Wigner's theorems: The role of symmetry equivalences in quantum systems
Authors: Zicovich‐Wilson Claudio M. , Erba Alessandro 
Published: June 2012

AbstractA generalization of the concept of Wigner's symmetrical operator, i.e., of the operator invariant under symmetry transformations forming a group, namely
${\cal G}$, is proposed here. Symmetrical operators in the present general sense do constitute a set whose elements are mutually commuting and equivalent to each other under transformations
${S_i} \in {\cal G}$. A generalization of a well known theorem attributed to Wigner is established: for a given operator Â and its equivalent ones Â[i] = Ŝ
ÂŜi, symmetrical as previously defined, it is always possible to find a complete set of common eigenfunctions that form canonical basis sets for representations of
${\cal G}$
induced by the largest subgroup
${\cal H} \subseteq {\cal G}$
whose elements keep Â invariant (the particular case
${\cal H} \equiv {\cal G}$
reduces to Wigner's theorem itself). The formal generalization presented here opens the possibility of describing and exploiting two complementary aspects of symmetry: invariance and equivalence, within a unified theoretical approach. It is also shown that the symmetry properties of the stationary solutions of Boys' localization functional obey a straightforward extension of this theorem. A few examples are provided to highlight the implications of this alternative way to look at symmetry in quantum systems. © 2012 Wiley Periodicals, Inc.
Density functional study on the geometric features and growing pattern of BnPm clusters with n = 1–4, m = 1–4, n + m ≤ 5
Authors: Curotto Verónica Ferraresi , Diez Reinaldo Pis 
Published: June 2012

AbstractThe bonding features of BnPm clusters (n = 1–4, m = 1–4, n + m ≤ 5) are studied within the framework of the density functional theory following a systematic growing mechanism. Some stable geometries are found to agree well with results reported previously in the literature. Other geometries are found to be more stable than structures reported elsewhere for small B/P aggregates. To the best of our knowledge, stable geometries for BP4 are reported for the first time. It is found that small B/P clusters with up to five atoms tend to grow mainly toward nonlinear bidimensional structures. The existence of BB and BP bonds seems to be of importance for the relative stability of clusters as they grow. The growing patterns could be explained mainly in terms of electrophilic attacks of B atoms to BB and BP bonds. It is found that the growing is in general accompanied by geometry reorganization and atomic charge rearrangements. Electrophilic attacks of P atoms to BB bonds seems to be a good alternative to grow for aggregates with many B atoms. Atomic charges derived from molecular electrostatic potentials are useful to understand the growing paths followed in terms of electrophilic or nucleophilic attacks. © 2012 Wiley Periodicals, Inc.
Inverse virtual screening studies of selected natural compounds from cerrado
Authors: Carregal Ana Paula , Comar Moacyr , Alves Stênio Nunes , Siqueira João Máximo de , Lima Luciana A. , Taranto Alex Gutterres 
Published: June 2012

AbstractSeveral medicinal plants have been studied in recent years in Brazil. However, despite many efforts, the pharmacological mechanisms of many natural products are still unknown. Several biological assays in vivo and in vitro are needed to further address this issue, which increases the cost of these studies. The main goal of this study was to apply the methodology of inverse virtual screening (IVS), followed by docking studies, and refinement by molecular dynamics (MD) simulation and quantum mechanical/molecular mechanical to determine the pharmacological receptors for five selected natural products with the exception of the benzoxazinone isolated from the exudate of the radicle of the crop species which were mainly isolated from the Cerrado species, obtained from Cerrado, a typical Brazilian biome. Initially, the structures of the natural compounds were generated using the online software program sc‐PDB, which searches for molecular targets deposited in the protein data bank. The ligands were docked against target proteins found in IVS step‐forming complexes, which were refined again using MD simulations by ff03 force field for 1 ns. Finally, the binding energy for each complex was obtained by the ONIOM (PM6:UFF) method. As a result, these calculations suggested possible molecular targets for these natural compounds. Among the targets found were 1EH4, 2A4Z, 1H49, 1JT2, 2BNJ, and 3FW9, which are involved in cancer and rheumatoid arthritis pathologies, indicating that they are promising molecular targets. In this study, we proposed a biological assay for these natural compounds. The results indicate that structural changes may be proposed to generate compounds that are able to bind more strongly to the receptor and become new drug candidates, thus optimizing the search for lead natural compounds. © 2012 Wiley Periodicals, Inc.
The role of operational flexibility in the expansion of international production networks
Authors: Fisch Jan Hendrik , Zschoche Miriam 
Published: June 2012

AbstractVolatile factor cost developments urge manufacturing firms to increase production efficiency by building up facilities in multiple countries. Differing from previous work that examines the quality of individual locations for investment, the study evaluates the net present value, the growth option value, and the operational flexibility value of the existing production network to predict the establishment of a new site. The results on a sample of 352 German manufacturing firms suggest that the direction, uncertainty, and diversity of labor cost movements in the extant locations influence the propensity to set up a new production subsidiary. Analyzing the international production network after the expansion shows that the new location increases the value of the network regarding these dimensions. Copyright © 2012 John Wiley & Sons, Ltd.
Toxicity of CdTe Quantum Dots on Yeast Saccharomyces Cerevisiae
Authors: Han Xiaole , Lai Lu , Tian Fangfang , Jiang Feng‐Lei , Xiao Qi , Li Yong , Yu Qiuliyang , Li Dongwei , Wang Jia , Zhang Qiumeng , Zhu Bofan , Li Ran , Liu Yi 
Published: June 2012

AbstractAlong with the widespread development of their bioapplications, concerns about the biosafety of quantum dots (QDs) have increasingly attracted intensive attention. This study examines the toxic effect and subcellular location of cadmium telluride (CdTe) QDs with different sizes against yeast Saccharomyces cerevisiae. The innovative approach is based on the combination of microcalorimetric, spectroscopic, electrochemical, and microscopic methods, which allows analysis of the toxic effect of CdTe QDs on S. cerevisiae and its mechanism. According to the values of the half inhibitory concentration (IC50), CdTe QDs exhibit marked cytotoxicity in yeast cells at concentrations as low as 80.81 nmol L−1 for green‐emitting CdTe QDs and 17.07 nmol L−1 for orange‐emitting CdTe QDs. QD‐induced cell death is characterized by cell wall breakage and cytoplasm blebbing. These findings suggest that QDs with sizes ranging from 4.1 to 5.8 nm can be internalized into yeast cells, which then leads to QD‐induced cytotoxicity. These studies provide valuable information for the design and development of aqueous QDs for biological applications.