bluuebunny/crossref_metadata_2025_split huggingface dataset:
External assessment of preoperative scores for predicting outcome after microvascular decompression for trigeminal neuralgia
Authors: Xie Michael E. , Halbert-Elliott Kyra , Nair Sumil K. , Jun Jinwoo , Dong Bryan C. , Ran Kathleen R. , Kilgore Collin B. , Kalluri Anita , Yedavalli Vivek S. , Jackson Christopher M. , Lim Michael , Huang Judy , Bettegowda Chetan , Xu Risheng 
Published: April 2024

OBJECTIVE
Recently, two scoring systems have been developed for predicting pain-free outcomes after microvascular decompression (MVD). Evaluation of these scores on large external datasets has been limited. In this study, the authors aimed to evaluate the performance of published MVD scoring systems in predicting pain-free outcome.

METHODS
A total of 458 patients who underwent MVD for trigeminal neuralgia (TN) between 2007 and 2020 and had at least 6 months of follow-up were included in this study. Hardaway and Panczykowski scores were retrospectively computed for each patient and compared with postoperative pain recurrence and pain-free duration.

RESULTS
The mean ± SD area under the receiver operating characteristic curve for predicting any pain recurrence after MVD was 0.567 ± 0.081 using the Hardaway score and 0.546 ± 0.085 using the Panczykowski score. On log-rank tests and Kaplan-Meier analysis, the patients with Hardaway scores of 0–2 had significantly shorter pain-free survival times after MVD than did those with a score of 3. Patients with a Panczykowski score of 1 had a significantly shorter pain-free duration after surgery compared with both patients with scores of 2–3 and patients with scores of 4–5. Patients with Panczykowski scores of 2–3 also had significantly shorter pain-free duration compared with patients with scores of 4–5.

CONCLUSIONS
Both the Hardaway and Panczykowski scores may be useful for predicting postoperative pain-free duration in TN patients, and their utility may be greatest when scores are clustered. Continued refinement of both scoring systems will help to improve our ability to predict patient outcomes after MVD.
Correlation of older age with better progression-free survival despite less aggressive resection in nonfunctioning pituitary adenomas
Authors: Shinya Yuki , Atkinson John L. D. , Erickson Dana , Bancos Irina , Pinheiro Neto Carlos D. , Davidge-Pitts Caroline J. , Peris Celda Maria , Herndon Justine S. , Hong Sukwoo , Van Gompel Jamie J. 
Published: April 2024

OBJECTIVE
Nonfunctioning pituitary adenomas (NFPAs) present at a wide range of ages; it is possible that variable outcomes are based on patient age at presentation. This study aimed to explore long-term outcomes of patients with NFPAs following endonasal transsphenoidal surgery (ETS), considering age stratification.

METHODS
This retrospective study included 228 patients with NFPAs who underwent ETS, with a median follow-up period of 63 months. The outcomes included progression-free survival (PFS) rates and neurological and endocrinological outcomes. Age-stratified Kaplan-Meier and Cox proportional hazards analyses were performed. Patients were classified into four age groups: ≤ 49, 50–59, 60–69, and ≥ 70 years.

RESULTS
Age-stratified analysis showed a significant correlation between age and PFS in NFPAs (5-year PFS rates: 63.0% in those ≤ 49 years, 76.7% in those 50–59 years, 85.0% in those 60–69 years, and 88.1% in those ≥ 70 years; p = 0.001, log-rank test). Bivariate (HR 1.03, 95% CI 1.01–1.05; p = 0.001) and multivariable (HR 1.03, 95% CI 1.02–1.05; p = 0.001) analyses demonstrated that older age was significantly associated with longer PFS. Multivariable analysis also demonstrated that smaller maximum tumor diameter (HR 0.77, 95% CI 0.60–0.99; p = 0.036) and gross-total resection (HR 8.55, 95% CI 3.90–18.75; p = 0.001) were significantly associated with longer PFS. Multivariable logistic regression analysis demonstrated that only younger age was associated with postoperative improvement of male hypogonadism (HR 0.91, 95% CI 0.84–0.99; p = 0.019). Other postoperative neurological and endocrinological outcomes were not significantly associated with age.

CONCLUSIONS
Older patients with NFPAs treated with ETS demonstrated a longer PFS. Of endocrinological outcomes studied, only male hypogonadism improvement was associated with younger patient age.
Optimal hippocampal targeting in responsive neurostimulation for mesial temporal lobe epilepsy
Authors: Skelton Henry M. , Bullinger Katie , Isbaine Faical , Lau Jonathan C. , Willie Jon T. , Gross Robert E. 
Published: April 2024

OBJECTIVE
The aim of this study was to identify features of responsive neurostimulation (RNS) lead configuration and contact placement associated with greater seizure reduction in mesial temporal lobe epilepsy (MTLE).

METHODS
A single-center series of patients with MTLE treated with RNS were retrospectively analyzed to assess the relationship between anatomical targeting and seizure reduction. Targeting was determined according to both the preoperatively conceived lead configuration and the actual placement of RNS contacts. Three lead configurations were used: 1) single bilateral, with 1 depth lead in each hippocampus; 2) single unilateral, with 1 hippocampal depth lead and another implant outside the mesial temporal lobe; and 3) dual unilateral, with 2 leads in 1 hippocampus. Contact placement on postoperative imaging was measured according to the number of hippocampal contacts per targeted hippocampus (contact density) and per patient (contact count), distribution throughout the hippocampus, and proximity to the anteromedial hippocampus.

RESULTS
Dual unilateral lead placement resulted in significantly higher hippocampal contact density compared with the single hippocampal approaches, but only showed a nonsignificant trend toward a higher rate of response. However, those patients with more than 4 contacts in a single hippocampus, achievable only with dual unilateral leads, had a significantly higher rate of response. The higher likelihood of response was poorly explained by more widespread hippocampal coverage, but well correlated with proximity to the anteromedial hippocampus.

CONCLUSIONS
Dual unilateral hippocampal implantation increased RNS contact density in patients with unilateral MTLE, which contributed to improved outcomes, not by stimulating more of the hippocampus, but instead by being more likely to stimulate a latent subtarget in the anterior hippocampus. It remains to be explored whether a single electrode targeted selectively to this region would also result in improved outcomes.
An inventory model where commodity prices depend on a continuous time Markov chain
Authors: Пресман Э.Л. , Сонин И.М. 
Published: April 2024

Рассматривается модель управления запасами, когда производитель (фирма) должен с постоянной интенсивностью использовать для производства промежуточный продукт (товар). Цена товара является цепью Маркова с непрерывным временем, конечным числом состояний и известными переходными интенсивностями. Фирма может покупать товар по текущей цене либо использовать уже купленный и хранящийся на складе. Стоимость хранения пропорциональна количеству хранящегося товара. Целью фирмы является минимизация ожидаемых дисконтированных суммарных издержек. Доказывается, что существует оптимальная стратегия и она носит пороговый характер, т. е. для каждого состояния марковской цепи существует оптимальный уровень хранения товара. Приводится алгоритм нахождения оптимальных порогов и построения оптимального значения функционала. Это значение, которое зависит от начального состояния цепи и начального уровня запаса, мы называем функцией выигрыша. Показывается, что, как правило, оптимальная стратегия единственна, но при некоторых соотношениях между параметрами единственности нет. Описываются все возможные случаи неединственности и все оптимальные управления. В типичных задачах оптимизации в непрерывном времени для нахождения оптимальной стратегии при анализе уравнения оптимальности (уравнение Беллмана) обычно используется гладкое склеивание первых производных функции выигрыша. Специфика нашей модели приводит к тому, что уравнение оптимальности удобно выписывать не в непрерывном, а в дискретном времени для вложенной марковской цепи, гладкое склеивание имеет место для второй производной от функции выигрыша, рассуждения удобно проводить не с функцией выигрыша, а с ее производной.
We present an inventory model where a manufacturer (firm) uses for “production” a “commodity” (resource), which is consumed with unit intensity. The price of the commodity follows a stochastic process, modelled by a continuous time Markov chain with a finite number of states and known transition rates. The firm can buy this commodity at the current price or use “stored’’ one. The storage cost is proportional to the storage level. The goal of the firm is to minimize the total discounted performance cost. We prove the existence of an optimal strategy, which is defined by a vector of levels specifying the minimal commodity amount to keep for a given price. This is so called the “threshold” strategy. We also describe all situations when such a strategy is not unique. We present an algorithm to find an optimal strategy and the corresponding value functions. In typical optimization problems in continuous time involving Bellman (optimality) equation, a smooth pasting of the first derivatives of the value functions is used. A special feature of our model is that, in contrast to such situations, we have to prove and to use the continuity of the second derivatives. The inventory model described in our paper may have broader interpretation when resources are replaced by assets, consumption by demand, and storage costs by opportunity costs or transaction costs.
Forecasting spending on orphan diseases to maintain the long-run financial sustainability of healthcare system
Authors: Расстригин М.А. , Китаев А.Е. , Плешакова Е.А. 
Published: April 2024

В статье рассматриваются особенности прогнозирования расходов на лечение редких заболеваний, для подавляющего большинства из которых в настоящее время отсутствует информация о точном числе пациентов. Актуальность проблемы обуславливается наращиванием многими странами расходов на лечение таких заболеваний. В исследовании представлен универсальный подход к прогнозированию расходов на лечение любого неинфекционного редкого заболевания. Для построения таких прогнозов использовался метод передвижки возрастов и минимальный набор экзогенных параметров. Апробация указанного подхода была осуществлена с использованием российских данных на примере муковисцидоза и болезни Помпе, отличающихся по степени изученности, распространенности среди населения и полноте информации, и конкретного заказчика — Фонда «Круг добра». Полученные оценки числа пациентов с этими заболеваниями в 2022 г. не содержат резких отклонений от фактических значений за 2019–2021 гг., при этом динамика ожидаемых до 2050 г. расходов на лечение данных заболеваний не противоречит опубликованным экспертным материалам. Полученные данные подтвердили авторскую гипотезу, согласно которой прогнозирование расходов на лечение слабо изученных редких заболеваний возможно без существенной потери качества, что, в свою очередь, позволяет организовать систему прогнозирования указанных расходов с использованием сопоставимых оценок по практически любым редким заболеваниям. Полученные результаты могут быть применены для совершенствования процесса принятия финансовых решений органами государственной власти, благотворительными организациями и фармацевтическими компаниями в отношении лечения редких заболеваний, а также в отношении оценки рынка для новых лекарственных препаратов.
The paper deals with the rare diseases’ burden forecasting in the context of information gaps on these diseases. There are many countries pumping up public funding for rare diseases’ treatment despite lack of accurate data on patients numbers. This study is aimed at the formulation the one-size-fi ts-all approach for forecasting treatment costs of rare NCD. The approach is based on cohort component method and requires minimum exogenous data set. The model utilizing the proposed approach was developed for forecasting The Circle of Good Foundation’s treatment costs on cystic fibrosis and Pompe’s disease in 2022–2050. The authors found that forecasted number of patients in 2022 does not deviate dramatically from actual data for 2019–2021 and predicted cost pattern does not conflict with experts up to 2050. This supports study’s hypothesis that the quality of treatment costs forecast does not depend signifi cantly on prevalence and degree of knowledge of rare disease. The results will be of interest to government authorities, charity foundations and pharmaceutical companies for upgrading decision-making on funding rare diseases’ treatment costs and improvement market planning for new drugs in pharmaceutical companies.
Vertical collusion in public procurement: Estimation based on data for R&D composite auctions
Authors: Белёв С.Г. , Ветеринаров В.В. , Матвеев Е.О. 
Published: April 2024

Одной из ключевых проблем в исследованиях государственных закупок является выявление признаков нарушений при их проведении, в том числе фаворитизма. В данной работе рассматриваются открытые конкурсы (с отбором победителя на основе не только ценового критерия) при закупках результатов научно-исследовательских и опытно-конструкторских работ (НИОКР) в России. С помощью показателя частоты взаимодействия были выделены поставщики, потенциально аффилированные с заказчиками. Результаты эконометрического моделирования позволяют сделать вывод, что потенциально аффилированные поставщики выигрывают с итоговой ценой ближе к начальной максимальной цене контракта (НМЦК), чем независимые поставщики. Этот результат устойчив к изменению спецификации и разным методам оценки. Потенциально аффилированные участники имеют более высокие качественные оценки в конкурсах с потенциально аффилированными организаторами. При этом независимые участники получают в таких конкурсах более низкие оценки. Таким образом, у потенциально аффилированного участника есть возможность ставить более высокую цену, выигрывая за счет завышенного качественного критерия.
One of the key problems in public procurement research is identifying violation signs, including vertical collusion. This paper discusses composite auctions (with a selection of a winner based not only on the price criterion) in the procurement for the results of research and development (R&D) work in Russia. Using the metric of interaction frequency, we identified suppliers that were potentially affiliated with customers. The results of econometric modeling suggest that potentially affiliated suppliers win with the final price closer to the initial maximum contract price (IMCP) than independent suppliers. This result is robust to specifi cation changes and different evaluation methods. Potentially affiliated participants have higher quality scores in contests with potentially affiliated organizers. At the same time, independent participants receive lower scores in such auctions. Therefore, a potentially affi iated participant could set a higher price, winning due to an overstated quality criterion.
CEO decision-making horizon and R&D investments. Evidence from Russia
Authors: Степанова А.Н. , Подухович Д.С. 
Published: April 2024

В этой статье поднимается проблема короткого горизонта принятия решений генеральных директоров публичных компаний и его влияния на инвестиции в будущее. Мы поднимаем этот вопрос для российского рынка, на котором как на волатильном развивающемся рынке проблема горизонтов инвестирования стоит остро. В этой работе на выборке из 76 российских компаний с 2013 по 2019 г. мы проверяем, как влияет горизонт принятия инвестиционных решений генерального директора в отношении исследований и разработок в России. В статье подтвержден факт наличия положительной зависимости между горизонтом решений и инвестициями в исследования и разработки на рассматриваемом рынке. Другими словами, личный короткий горизонт решений генерального директора значимо снижает инвестиции в исследования и разработки. Показано, что факт наличия давления на показатели эффективности компаний сокращает протяженность горизонта принятия решений генерального директора компаний. Интересно, что в предпандемийные годы, с 2016 по 2019 г., влияние на протяженность горизонта решений генерального директора компаний в отношении инвестиций в исследования и разработки становится сильнее. Полученные результаты могут иметь практическое применение в области определения стимулирующих контрактов и выплат бонусов менеджерам компаний.
Current paper raises the question of short-term decision horizon problem of a CEO and its influence on company’s future investments. We investigate the presence of such a problem on the Russian market on which this kind of problem seems to be more pronounced. In this paper, on a sample of 76 Russian companies from 2013 to 2019, we examine how CEO’s short-term investment horizon affects R&D in Russia. Firstly, we confirmed the existence of a positive relationship between the decision horizon and investment in R&D in the Russian market. In other words, the personal short termism of top managers significantly reduces company’s investments in R&D. Secondly, we showed that performance pressure on companies from the industry reduces the length of the CEO’s decision horizon. Moreover, if we shorten observation period and take pre-pandemic years 2016–2019, the influence of the CEO horizon on investment in R&D becomes stronger. The results of our research may have practical application in determining incentive contracts and bonus payments to top managers.
Penerapan Unsur Tindak Pidana Aborsi Oleh Penyidik Berdasarkan Alat Bukti Yang Digunakan
Authors: Lesmono Joko Hendro , Fitriati  
Published: April 2024

Sanksi pidana terhadap wanita yang menggugurkan kandungannya tercantum pada Pasal 75 ayat (1) Undang-Undang Nomor 36 Tahun 2009 Tentang Kesehatan. Penelitian ini merupakan penelitian hukum dengan spesifikasi yang bersifat deskriptif analitis. Penerapan unsur tindak pidana aborsi oleh penyidik pada Satreskrim Polresta Padang dengan penggunaan alat bukti berupa keterangan saksi, keterangan ahli dan surat. Surat berupa rekaman medis, dokumen terkait lainnya dan keterangan ahli berupa penjelasan dari ahli kefarmasian mengenai jenis obat yang digunakan dan akibat dari penggunaan obat tersebut. Pada alat bukti Keterangan Saksi, Penyidik memperoleh informasi terkait cara dilakukan aborsi. Saksi-saksi ini terdiri dari petugas medis, saksi mata, atau orang yang terlibat dalam tindakan tersebut. Keterangan Ahli yaitu Ahli medis atau ahli forensik dapat memberikan keterangan apakah aborsi tersebut ilegal atau tidak. Serta ahli kefarmasiaan yang menerangkan tentang indikasi obat yang digunakan. Kendala Penerapan unsur tindak pidana aborsi oleh penyidik pada Satreskrim Polresta Padang dengan pengunaan alat bukti adalah kurangnya kemampuan Petugas Penyidik dalam menggunakan alat bukti seperti alat bukti rekam medis dan obat-obatan. Sulitnya mencari saksi juga menjadi permasalahan dalam proses penyidikan. Pihak kepolisian kesulitan dalam mencari informasi dan mengumpulkan data tersangka yang berhubungan dengan kasus tidak pidana aborsi, karena aborsi merupakan aib bagi seorang wanita yang berarti jika memberikan informasi berarti membuka aib mereka sendiri. Sulitnya membuka rahasia medis Pasien yang enggan memberikan keterangan atau alat bukti yang memadai kepada penyidik, karena takut atau karena faktor-faktor pribadi. Aborsi sering dilakukan secara diam-diam, dan bukti fisik mungkin terbatas atau sulit diakses. Ini bisa menjadi kendala dalam memastikan adanya tindakan aborsi ilegal. Hukum dan regulasi yang rumit, setiap yurisdiksi memiliki hukum yang berbeda terkait aborsi, dan hal ini dapat mempengaruhi cara penyidik mengumpulkan dan menggunakan bukti dalam penyidikan. Pada beberapa kasus, penyidik mungkin menghadapi keterbatasan teknologi dalam mengumpulkan bukti, terutama jika mereka harus mengandalkan rekaman medis atau perangkat lainnya.
Impact Motivasi Investasi, Literasi Keuangan, dan Perilaku Keuangan Terhadap Keputusan Investasi
Authors: Ratna Gumilang Risa , Amanda Helles , Ginanjar Yayat 
Published: April 2024

This study aims to examine the effect of investment motivation, financial literacy and financial behavior on investment decisions. This type of research is quantitative research using descriptive methods. The data processed is primary data obtained from the results of distributing questionnaires with simple random sampling technique to students of the management study program at Sebelas April University. The research sample is 246 respondents. Data analysis was performed using the PLS (Partial Least Square) program. The results of this study indicate that there is a positive and significant influence of investment motivation, financial literacy and financial behavior on investment decisions. Financial literacy needs to be improved so that students are more motivated to make investments and have good finances for the future.
Pengolahan Ikan untuk Pemberdayaan Masyarakat di Kelurahan Harjosari Pekanbaru
Authors: Arsil Yuliana , Restusari Lily , Mulyani Sri 
Published: April 2024

ABSTRAK Pekanbaru merupakan kota yang memiliki sentral produksi perikanan yang cukup tinggi. Akses untuk memperoleh perikanan diseluruh wilayah kota Pekanbaru sangat mudah terutama di kelurahan Harjosari yang berada di Pusat kota. Ikan merupakan sumber protein hewani yang memiliki peran penting untuk tubuh. Pemanfaatan ikan sebagian besar masih sebatas ikan konsumsi serta kurangnya variasi dalam pengolahan ikan menyebabkan kurangnya minat konsumsi ikan terutama bagi anak-anak. Melakukan diversifikasi pangan tentunya akan meningkatkan kualitas dari produk pangan dan salah satu upaya dalam meningkatkan konsumsi ikan. Meningkatkan pengetahuan dan keterampilan masyarakat dalam mengolah ikan. Meliputi sosialisasi dan diskusi awal, penyuluhan Praktik dan evaluasi. Pengetahuan peserta pengabdian masyarakat sebelum penyuluhan dengan rata-rata 73, dan setelah penyuluhan meningkat menjadi 92. Keterampilan peserta mengolah ikan dalam kategori baik. Peserta pengabdian masyarakat mengalami peningkatan pengetahuan dan mampu melakukan praktik pengolahan ikan. Kata Kunci: Pangan Lokal, Teknologi, Diversifikasi, Pengetahuan ABSTRACT Pekanbaru is a city that has a fairly high fisheries production center. Access to fisheries throughout the Pekanbaru city area is very easy, especially in the Harjosari village which is located in the city center. Fish is a source of animal protein which has an important role for the body. The utilization of fish mostly is still limited to simple consumption with lack of variety in the fish processing which causes a lack of interest in consuming fish, especially for children. Diversifying the food will certainly improve the quality of food products and this is one of the efforts to increase fish consumption. To increase the community's knowledge and skills in processing fish. Includes socialization and initial discussion, counseling related to fish processing, practices and evaluation. Knowledge of community service participants before counseling with an average of 73, and after counseling increased to 92. Participants' skills in processing fish are in the good category. Community service participants obtain Increased knowledge and skills in fish processing. Keywords: Local Food, Technology, Diversification, Knowledge