bluuebunny/crossref_metadata_2025_split huggingface dataset:
HHIP protein interactions in lung cells provide insight into COPD pathogenesis
Authors: Deritei Dávid , Inuzuka Hiroyuki , Castaldi Peter J , Yun Jeong Hyun , Xu Zhonghui , Anamika Wardatul Jannat , Asara John M , Guo Feng , Zhou Xiaobo , Glass Kimberly , Wei Wenyi , Silverman Edwin K 
Published: February 2025

Abstract
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. The primary causes of COPD are environmental, including cigarette smoking; however, genetic susceptibility also contributes to COPD risk. Genome-Wide Association Studies (GWASes) have revealed more than 80 genetic loci associated with COPD, leading to the identification of multiple COPD GWAS genes. However, the biological relationships between the identified COPD susceptibility genes are largely unknown. Genes associated with a complex disease are often in close network proximity, i.e. their protein products often interact directly with each other and/or similar proteins. In this study, we use affinity purification mass spectrometry (AP-MS) to identify protein interactions with HHIP, a well-established COPD GWAS gene which is part of the sonic hedgehog pathway, in two disease-relevant lung cell lines (IMR90 and 16HBE). To better understand the network neighborhood of HHIP, its proximity to the protein products of other COPD GWAS genes, and its functional role in COPD pathogenesis, we create HUBRIS, a protein–protein interaction network compiled from 8 publicly available databases. We identified both common and cell type-specific protein–protein interactors of HHIP. We find that our newly identified interactions shorten the network distance between HHIP and the protein products of several COPD GWAS genes, including DSP, MFAP2, TET2, and FBLN5. These new shorter paths include proteins that are encoded by genes involved in extracellular matrix and tissue organization. We found and validated interactions to proteins that provide new insights into COPD pathobiology, including CAVIN1 (IMR90) and TP53 (16HBE). The newly discovered HHIP interactions with CAVIN1 and TP53 implicate HHIP in response to oxidative stress.
Calibrating the absolute magnitude of type Ia supernovae in nearby galaxies using [OII] and implications for H0
Authors: Dixon M , Mould J , Lidman C , Taylor E N , Flynn C , Duffy A R , Galbany L , Scolnic D , Davis T M , Möller A , Kelsey L , Lee J , Wiseman P , Vincenzi M , Shah P , Aguena M , Allam S S , Alves O , Bacon D , Bocquet S , Brooks D , Burke D L , Rosell A Carnero , Carollo D , Carretero J , Conselice C , da Costa L N , Pereira M E S , Diehl H T , Doel P , Everett S , Ferrero I , Flaugher B , Frieman J , García-Bellido J , Gatti M , Gaztanaga E , Giannini G , Gruen D , Gruendl R A , Gutierrez G , Herner K , Hinton S R , Hollowood D L , Honscheid K , James D J , Kuehn K , Lima M , Marshall J L , Mena-Fernández J , Menanteau F , Miquel R , Myles J , Nichol R C , Ogando R L C , Palmese A , Pieres A , Malagón A A Plazas , Samuroff S , Sanchez E , Cid D Sanchez , Sevilla-Noarbe I , Smith M , Sobreira F , Suchyta E , Swanson M E C , Tarle G , To C , Tucker B E , Tucker D L , Vikram V , Walker A R , Weaverdyck N 
Published: February 2025

Abstract
The present state of cosmology is facing a crisis where there is a fundamental disagreement in measurements of the Hubble constant (H0), with significant tension between the early and late universe methods. Type Ia supernovae (SNe Ia) are important to measuring H0 through the astronomical distance ladder. However, there remains potential to better standardise SN Ia light curves by using known dependencies on host galaxy properties after the standard light curve width and colour corrections have been applied to the peak SN Ia luminosities. To explore this, we use the 5-year photometrically identified SNe Ia sample obtained by the Dark Energy Survey, along with host galaxy spectra obtained by the Australian Dark Energy Survey. Using host galaxy spectroscopy, we find a significant trend with the equivalent width (EW) of the [OII] λλ 3727, 29 doublet, a proxy for specific star formation rate, and Hubble residuals. We find that the correlation with [OII] EW is a powerful alternative to the commonly used mass step after initial light curve corrections. Applying this [OII] EW correction to 20 SNe Ia in calibrator galaxies observed with WiFeS, we examined the impact on SN Ia absolute magnitudes and H0. Our [OII] EW corrections result in H0 values ranging between 73.04 to 73.51kms−1Mpc−1, with a combined statistical and systematic uncertainty of ∼1.31kms−1Mpc−1. However, even with this additional correction, the impact of host galaxy properties in standardising SNe Ia appears limited in reducing the current tension (∼5σ) with the CMB result for H0.
The association between healthy lifestyle and multimorbidity of non-communicable chronic diseases trajectory: evidence from a perspective study in UK biobank
Authors: Wu Jinrong , Jiang Wenbo , Ji Ce , Qiao Conghui , Wei Wei , Wang Yupeng 
Published: February 2025

Abstract

Background
Although a few studies have found that healthy lifestyle is linked to a range of non-communicable chronic diseases (NCDs), its association with the onset, progression, and prognosis of multimorbidity of NCDs (MNCDs) has never been studied.

Method
A total of 332 444 adults aged 39–73 years who were free of heart disease, stroke, diabetes, and cancer at baseline were selected. Then we used multi-state model to analyze the associations between healthy lifestyle and transition trajectory were analyzed with results expressed as hazard ratio (HR) and 95% confidence interval.

Results
A total of 62 994 participants developed first NCDs (FNCDs). After adjustment for potential confounders, healthy lifestyle was negatively associated with the transition trajectory from baseline to FNCD (HR = 0.38), from FNCDs to MNCDs (HR = 0.30), etc. Further, the transition trajectory from FNCDs to MNCDs became more pronounced among the offspring who aged ˂60 (HRFNCDs → MNCDs = 0.29), who never took medicine(HRFNCDs → MNCDs = 0.25). Besides, possessing all five healthy lifestyle factors could extend the life expectancy of MNCD participants.

Conclusion
This study suggests that healthy lifestyle is associated with almost all transition phases of MNCDs development and decreases the mortality risk of MNCDs.
Characterization of the Rbfox3‐IRES‐iCre knock‐in mouse: Revealing gene recombination activity in neural and non‐neural peripheral tissues
Authors: Nishino Shiho , Hashimoto Misuzu , Biswas Swapna Paramanya , Mikami Natsuki , Hasegawa Yoshikazu , Suzuki Hayate , Kang Woojin , Mizuno Seiya , Murata Kazuya 
Published: February 2025

AbstractIn vivo cell type‐specific genetic recombination based on the Cre‐loxP system has contributed to the understanding of biological processes and diseases. Neuronal nuclei (NeuN)/RBFOX3 is a widely used mature neuron marker in developmental biology and neuroscience. Here, we generated Rbfox3‐improved Cre (iCre) knock‐in mouse model and investigated the effect of iCre knock‐in into the Rbfox3 gene and Cre recombination activity in the central nervous system (CNS) and peripheral tissues. The knock‐in of internal ribosome entry site (IRES)‐iCre cassette into the Rbfox3 3′ UTR did not affect birth rate, growth, and brain weight. In the adult brain, iCre protein expression was confirmed, whereas RBFOX3 protein expression was partially reduced in the knock‐in mice. Cre recombination analysis using R26GRR fluorescent reporter strain revealed that Rbfox3‐driven iCre‐induced gene recombination in the CNS and heart during embryonic development. In the adult brain, gene recombination was observed in neurons, however, not in other glial cells. In the peripheral tissues, iCre activity was found in the sciatic nerve and in other peripheral tissues, including the heart, bladder, and testis. We validated gene recombination rate in the germline and found that 100% recombination occurred in male germ cells and approximately 50% in female germ cells. Concludingly, Rbfox3‐iCre mice induce genetic recombination in neurons within CNS as well as in some peripheral tissues and germ cells. In addition to establishing a novel Cre mouse line, the findings of this study offer valuable insights into the development and application of mouse tools that utilize the Rbfox3 gene locus.
Inborn errors of immunity with atopic phenotypes in the allergy and immunology clinic: a practical review
Authors: Taietti Ivan , Catamerò Francesco , Lodi Lorenzo , Giovannini Mattia , Castagnoli Riccardo 
Published: February 2025

Purpose of review
Inborn errors of immunity with atopic phenotypes (IEIwA) are a subgroup of IEI that may present with severe and/or multiple atopic clinical manifestations. Because of their specific clinical management and prognosis, it is important to distinguish IEIwA from multifactorial allergic diseases. We aimed to review the main clinical manifestations associated with IEIwA and summarize the available data regarding the precision medicine approach for these conditions.

Recent findings
IEIwA include more than 50 monogenic disorders marked by different immune dysregulation mechanisms such as alterations in cytokine signaling, T cell receptor function, mast cell activation, and skin barrier integrity. A critical role in diagnosis is played by advanced genetic testing. Emerging treatments include targeted monoclonal antibodies and small molecules, whereas hematopoietic stem cell transplantation (HSCT) is still a valid option for some specific disorders and may be curative also on atopic manifestations.

Summary
The recognition and accurate diagnosis of IEIwA are crucial for timely and appropriate therapeutic intervention. The diagnosis should be suspected according to the presence of ‘red flags’ at clinical evaluation stage, such as early-onset severe atopy, recurrent/atypical infections, and autoimmunity. The diagnostic confirmation requires genetic testing. Precision medicine approaches like biological therapies and HSCT seem to provide promising results. It is worth noting that clinical and translational research in the field of IEIwA is currently paving the way for a more thorough understanding of the molecular bases of common allergic diseases.
Moving More: Physical Activity and Its Positive Effects on Depression and Anxiety in Children and Young People
Authors: Bevan Emma , Sheridan Craig , Botchey Sam , Kelly Paul , Reid Hamish 
Published: February 2025

Objective:
This project has 2 aims: First, to identify and summarize the most clinically important aspects of the published evidence on physical activity and sport in children and young people for the treatment or prevention of depression, anxiety, or symptoms of these conditions. Second, this study aims to funnel and develop this evidence to create clinically meaningful summaries on the Moving Medicine website and to guide clinicians on the day-to-day conversations clinicians have with children and young people about the benefits of physical activity for mental health.

Design:
This mixed methods study combines a scoping review with expert clinical review using the knowledge creation funnel component of the KTA framework.

Data sources:
We searched Pubmed, OvidSp, Cochrane, OvidEmbase, OvidEmcare and AMED databases using the following search strategy, which included appropriate truncation symbols to account for variations of the search terms and maximize searches: Depression OR depressed OR anxiety OR “generalised anxiety disorder” OR anxious* OR “low mood” OR “Mood disorder” AND Children OR Child OR adolescen* OR teenager OR “young people*” OR “young person*” AND Exercise OR “physical activ*” OR sport OR “Physically activ*”.

Results:
Sixty-eight studies were included in this review, and evidence suggested that interventions of varying intensity can reduce symptoms of depression and anxiety in children and young people. The effects of physical activity on other mental health outcomes were also encouraging. The available evidence suggests that physical activity is a promising strategy to improve mental health in children and young people.

Conclusions:
The literature overwhelmingly supports the benefits of regular physical activity both in the prevention of mental health issues for children and young people and in reduction of symptoms for those with already established symptoms. This review has translated this knowledge into accessible and relevant resources for healthcare professionals to use in their practice.
Improving Perinatal HIV Care during the COVID-19 Pandemic: Implementing a Mobile Integrated Health Program to Close the Gap
Authors: Ramakrishnan Aditi , Goldstein Madeleine , Shetty Shakti , Badell Martina , Kalokhe Ameeta S. , Colasanti Jonathan , Sumitani Jieri , LaTeshia Thomas-Seaton , Beaupierre Melissa , Hussen Sophia A. , Sheth Anandi N. 
Published: February 2025

Background:
Pregnant people with HIV (PWH) often experience loss to follow-up and viral non-suppression after delivery, contributing to morbidity and HIV transmission. The COVID-19 pandemic disrupted health systems and exacerbated health disparities, including for PWH and their infants. To improve perinatal HIV outcomes, we implemented a perinatal care program in September 2020 that offered multidisciplinary home visits through a Mobile Integrated Health (MIH) unit within a large, safety-net healthcare system in Atlanta, Georgia.

Methods:
We analyzed data collected from PWH who delivered one year before (8/31/19-8/31/20; pre-implementation) to six months after (9/1/20-2/28/21; post-implementation) MIH implementation to compare HIV clinical outcomes. We evaluated barriers, facilitators, and patient preferences through exit surveys with MIH program participants.

Results:
Overall, 32 (53%) delivered before and 28 (47%) PWH delivered after MIH implementation; majority were non-Hispanic Black. Three-fourths who delivered post-MIH utilized MIH, mostly (62%) for postpartum obstetric visits. HIV visit attendance within 3 months and retention in care at 6 months of delivery were significantly higher post-implementation (p = 0.04). Participants noted that the MIH program significantly improved appointment scheduling and access to healthcare services during the pandemic (p < 0.05). Participants highly rated the preferability, convenience, safety, and use of the MIH program for future pregnancies.

Conclusions:
Implementation of a perinatal MIH program for PWH and their infants led to significant improvement in engagement in HIV care after delivery. Our findings demonstrate that novel, interdisciplinary programming can fill critical gaps in care delivery, including during periods of healthcare disruption.
Development of a questionnaire library for rapid health data acquisition during wildfire events
Authors: Liu Lilian , Loftus Christine , Rohlman Diana , Seto Edmund , Austin Elena 
Published: February 2025

AbstractRapid health outcome data acquisition using existing questionnaires can greatly facilitate time-sensitive research during or after a wildfire event. We aimed to develop a readily available library of questionnaires for self-reported health outcomes to serve as a centralized platform for wildfire researchers seeking to quickly design instruments tailored to their research aims. In this paper, we describe the methodology used to identify relevant health questionnaires and compile them into a structured library. We first followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 checklist and performed a systematic literature review of prior research on wildfire exposure and health and used this to 1)identify health outcome categories associated with wildfire and smoke exposure and 2) extract questionnaires used for self-report of health outcomes related to wildfire exposure. We also performed a secondary search of existing questionnaire repositories to identify additional instruments relevant to health impacts of wildfire exposure. All questionnaires (n=100) were organized by eight health outcome categories (mental health = 60, respiratory health = 19, overall health = 17, sleep = 10, cardiovascular health = 4, allergy = 1, irritation (eye, throat, skin) = 2, and metabolic health = 1). Thelibrary(see supplementary information) will be accompanied by a decision-tree framework in development, which will assist future users in building new questionnaires that best fit their study population and research aims. Both the questionnaire library and the forthcoming decision-support framework will be publicly accessible to researchers, public health agencies, and other groups interested in rapid response data collection to characterize the impacts of wildfires. Additionally, this method of creating a wildfire exposure health questionnaire library may serve as a template for rapid collection of questionnaire-based data following other disasters.
Spatial dynamics of the tumor microenvironment associated with emerging resistance to targeted therapy inEGFR-mutated non–small cell lung cancer
Authors: Nakamura Satoshi , Shibahara Daisuke , Tanaka Kentaro , Kishikawa Yasuyuki , Hashisako Mikiko , Nakatomi Keita , Nakagaki Noriaki , Kohno Mikihiro , Azuma Koichi , Ibusuki Ritsu , Otsubo Kohei , Yoneshima Yasuto , Iwama Eiji , Oda Yoshinao , Okamoto Isamu 
Published: February 2025

ABSTRACTEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide therapeutic benefit inEGFRmutation–positive non–small cell lung cancer, but some individuals develop early resistance. We performed spatial transcriptomics analysis of pre- and posttreatment tumor samples from the same patients to explore the underlying mechanisms of such early resistance. The proportion and activation of fibroblasts increased in association with the development of early resistance, whereas a distinct tumor cell cluster showed activation of tumor necrosis factor–α signaling via the NF-κB pathway even before treatment. Also in the early resistance sample, specific tumor cell clusters interacted with immune and stromal cells. Immature tertiary lymphoid structures (TLSs) were enriched in the early resistance sample, whereas mature TLSs were observed in the long-term response sample. These findings implicate tumor heterogeneity and an inflammatory tumor microenvironment in early EGFR-TKI resistance, providing insight into potential therapeutic strategies to improve treatment outcomes.
Women’s experiences collecting and accessing water in Guatemala, Honduras, Kenya, and Zimbabwe: A mixed-methods investigation
Authors: Caruso Bethany A. , Mink Thea , Patrick Madeleine , Ogutu Emily , Dawkins Cameron , Bendit Olivia , Fatima Mahnoor , Lustig Ingrid , Macler Alicia , White Jera , Zamora Alondra , Santos López Alberto Emanuel , Peña Ramírez Héctor Salvador , Sic Carlos Daniel , Chávez Jorge Lemus , Antonio Sandra , Irías Jazmina Nohemí , Ramos Gladys , Atandi Everlyne , Mwangi Peter , Koome Peter , Otieno Onyango Rohin , Otuya Petronilla Andiba , Ruto Paul , Chidavaenzi Morris , Jimu Jammaine , Maphosa Sithandekile , Maworera Makaita , Damson Munyaradzi , Sinharoy Sheela S. 
Published: February 2025

ABSTRACT1.8 billion people live in households that collect water from sources off household premises, creating burdens that disproportionately affect women. A current and comprehensive investigation of women’s water collection experiences is needed to understand the gendered burden of this labor. This study used mixed methods, including (a) go-along, in-depth interviews (IDIs), (b) semi-structured observation, (c) activity-tracking smart watches, and (d) scales, to (1) understand women’s practices, perspectives, and experiences going to water sources; (2) determine actual water collection time, distance, caloric expenditure, total elevation ascended, weight carried, and water volume collected; and (3) assess alignment of women’s estimated and actual water journey times. Ninety-four women participated across four countries: Guatemala (n=22), Honduras (n=17), Kenya (n=22), Zimbabwe (n=33). Women reported accessing various sources depending on season and needs, faced risks due to terrain and animals, and experienced physical injury and mental burden. Experiences varied within and by country. The mean water journey time (including going to the source, activities at the source, and returning) was 82 minutes (range: 13 minutes (Guatemala) – 287 minutes (Kenya)). The mean distance traveled was 3.5km (range: 0.2km (Guatemala, Honduras, Zimbabwe) - 15.8km (Kenya)). Mean caloric expenditure was 231cal (range: 36 (Guatemala) – 952 (Zimbabwe)). The mean volume of water collected was 16.1L. (range: 3.7L (Kenya) - 38.2L (Zimbabwe). Women also carried children, wet laundry, and other items resulting in heavy loads. The mean total weight of loads brought from water sources was 19.3kg (range: 5.0kg (Honduras) - 50.1kg (Zimbabwe). Findings demonstrate how a lack of adequate and accessible water drains women of energy and time and poses risks to their well-being. Our findings reinforce the need to redouble efforts to improve water access in low-resource settings and rigorously measure the impacts of such efforts on women’s lives.
Fostering English-major students’ team creativity and collaboration through design thinking
Authors: Kaoropthai Chayaporn 
Published: February 2025

PurposeDesign thinking, as a creative and innovative methodology, has been proposed as a process for non-designers to address complex problems. The purpose of this study was to investigate the effectiveness of using design thinking to foster English-major students’ team creativity and collaboration.Design/methodology/approachThis study employed a quasi-experimental design and was conducted online via Google Classroom. A purposive sample of 31 English-major students from a workplace action research class was used as participants of the study. Design thinking was introduced and employed to foster students’ team creativity and collaboration in the development of group research proposals. The four instruments used to collect the data included: team creativity questionnaire, team collaboration questionnaire, product satisfaction questionnaire and product quality questionnaire.FindingsThe results of the study revealed that mean scores of the four outcome variables: team creativity (4.31), team collaboration (4.20), product satisfaction (4.33) and product quality (3.87), were all at a “high” level, supporting that the approach promoted team creativity and team collaboration. Additionally, the correlations between team creativity and product satisfaction (0.49) and team collaboration and product quality (0.33) were both at a “moderate-substantial” level, potentially indicating their roles in ensuring rigorous output.Originality/valueThis research is significant because it provides new insights into the use of design thinking to foster students’ team creativity and collaboration in an action research course.