bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Neonatal Jaundice and Phototherapy on the Frequency of First-Year Outpatient Visits
Authors: Usatin Danielle , Liljestrand Petra , Kuzniewicz Michael W. , Escobar Gabriel J. , Newman Thomas B. 
Published: March 2010

OBJECTIVE:The objective of this study was to determine whether either hyperbilirubinemia or inpatient phototherapy is associated with increased subsequent outpatient visit rates, a possible effect of the “vulnerable child syndrome.”METHODS:We compared 3 groups of otherwise well term and late-preterm infants who were born between 1995 and 2004 in Northern California Kaiser hospitals: group 1 never had a documented total serum bilirubin (TSB) level ≥12 mg/dL (n = 128 417); group 2 had a TSB level ≥17 and &lt;23 mg/dL as outpatients between 48 hours and 7 days of age and did not receive inpatient phototherapy (n = 6777); and group 3 met criteria for group 2 but did receive inpatient phototherapy (n = 1765). We compared outpatient visit rates from 15 to 364 days of age adjusting for other predictors of visit rates by using Poisson and linear regression.RESULTS:The mean total number of visits between 15 and 364 days was 9.83. Compared with group 1, adjusted total first-year visit rates were slightly increased in group 2 (adjusted incidence rate ratio: 1.04 [95% confidence interval: 1.02–1.05]) and group 3 (incidence rate ratio: 1.07 [95% confidence interval: 1.05–1.10]). The increases in visit rates were greatest for visits from 15 to 59 days of age, for specialty visits, and for unspecified diagnoses. These rates correspond to adjusted increases in total first-year visits (compared with group 1) of 0.36 visits in group 2 and 0.73 visits in group 3.CONCLUSIONS:Neonatal jaundice and inpatient phototherapy are associated with only small increases in first-year outpatient visit rates, consistent with mild or infrequent contribution to the vulnerable child syndrome in this population.
Adolescent Violence Perpetration: Associations With Multiple Types of Adverse Childhood Experiences
Authors: Duke Naomi N. , Pettingell Sandra L. , McMorris Barbara J. , Borowsky Iris W. 
Published: March 2010

OBJECTIVE:Adverse childhood experiences are associated with significant functional impairment and life lost in adolescence and adulthood. This study identified relationships between multiple types of adverse events and distinct categories of adolescent violence perpetration.METHODS:Data are from 136 549 students in the 6th, 9th, and 12th grades who responded to the 2007 Minnesota Student Survey, an anonymous, self-report survey examining youth health behaviors and perceptions, characteristics of primary socializing domains, and youth engagement. Linear and logistic regression models were used to determine if 6 types of adverse experiences including physical abuse, sexual abuse by family and/or other persons, witnessing abuse, and household dysfunction caused by family alcohol and/or drug use were significantly associated with risk of adolescent violence perpetration after adjustment for demographic covariates. An adverse-events score was entered into regression models to test for a dose-response relationship between the event score and violence outcomes. All analyses were stratified according to gender.RESULTS:More than 1 in 4 youth (28.9%) reported at least 1 adverse childhood experience. The most commonly reported adverse experience was alcohol abuse by a household family member that caused problems. Each type of adverse childhood experience was significantly associated with adolescent interpersonal violence perpetration (delinquency, bullying, physical fighting, dating violence, weapon-carrying on school property) and self-directed violence (self-mutilatory behavior, suicidal ideation, and suicide attempt). For each additional type of adverse event reported by youth, the risk of violence perpetration increased 35% to 144%.CONCLUSIONS:Multiple types of adverse childhood experiences should be considered as risk factors for a spectrum of violence-related outcomes during adolescence. Providers and advocates should be aware of the interrelatedness and cumulative impact of adverse-event types. Study findings support broadening the current discourse on types of adverse events when considering pathways from child maltreatment to adolescent perpetration of delinquent and violent outcomes.
Camel No. 9 Cigarette-Marketing Campaign Targeted Young Teenage Girls
Authors: Pierce John P. , Messer Karen , James Lisa E. , White Martha M. , Kealey Sheila , Vallone Donna M. , Healton Cheryl G. 
Published: March 2010

CONTEXT:
The 1998 Master Settlement Agreement (MSA) restricted tobacco industry advertising practices that targeted teens.

OBJECTIVE:
To assess whether cigarette-advertising campaigns conducted after the MSA continue to influence smoking among adolescents.

DESIGN, SETTING, AND PARTICIPANTS:
Participants were a national longitudinal cohort of 1036 adolescents (baseline age: 10–13 years) enrolled in a parenting study. Between 2003 and 2008, 5 sequential telephone interviews were conducted, including the participant's report of brand of “favorite” cigarette advertisement. The fifth interview was conducted after the start of RJ Reynolds' innovative “Camel No. 9” advertising campaign in 2007. Smoking outcome reported from the fifth survey.

RESULTS:
The response rate through the fifth survey was 71.8%. Teenagers who reported any favorite cigarette ad at baseline (mean age: 11.7 years) were 50% more likely to have smoked by the fifth interview (adjusted odds ratio: 1.5 [95% confidence interval: 1.0–2.3]). For boys, the proportion with a favorite ad was stable across all 5 surveys, as it was for girls across the first 4 surveys. However, after the start of the Camel No. 9 advertising campaign, the proportion of girls who reported a favorite ad increased by 10 percentage points, to 44%. The Camel brand accounted almost entirely for this increase, and the proportion of each gender that nominated the Marlboro brand remained relatively stable.

CONCLUSIONS:
After the MSA, adolescents continued to be responsive to cigarette advertising, and those who were responsive were more likely to start smoking. Recent RJ Reynolds advertising may be effectively targeting adolescent girls.
Effectiveness of the Informed Consent Process for a Pediatric Resuscitation Trial
Authors: Raymond Tia Tortoriello , Carroll Timothy Glenn , Sales Glenda , Morris Marilyn Cummings 
Published: March 2010

OBJECTIVE:
When prospective informed consent is not feasible, clinical research that presents more than minimal risk can proceed only with an exception from informed consent. Our objectives were (1) to describe the in-hospital community consultation and public disclosure process for a clinical trial and (2) to evaluate our in-hospital public disclosure process.

METHODS:
Community consultation included parents, providers, and administrators in a PICU via focus groups, conferences, and other methods. Public disclosure consisted of a brochure and a poster in all PICU waiting rooms. These materials described risks and benefits of the trial, that no consent would be sought, how to “opt out,” and how to provide feedback. A verbal questionnaire was administered to parents of potential patients during the trial to evaluate the public disclosure process.

RESULTS:
Eighty-one percent of 93 parents were aware of the ongoing trial. Seventy-six of 93 remembered seeing the brochure; of these, 26% did not read, 39% read quickly, and 35% read carefully. Thirty-seven of 93 parents remembered seeing the poster; of these, 51% did not read, 32% read quickly, and 17% read carefully. Sixty-seven percent reported that they would want to participate in the study, 9% would not, and 24% were undecided. Of the 7 parents who did not want to participate, 3 had opted out and 4 were unaware that they could opt out.

CONCLUSIONS:
Parents endorsed resuscitation research with an exception from informed consent. Public disclosure yielded &gt;80% parental awareness. Efforts should be made to ensure awareness of the ability to opt out.
Phenylcopper(I) clusters in the gas phase obtained by laser desorption/ionization from bis(dibenzoylmethane)copper(II)
Authors: Frański Rafał , Kozik Tomasz , Staniszewski Bartosz , Urbaniak Włodzimierz 
Published: March 2010

Abstract
It has been demonstrated that phenylcopper(I)-containing clusters are generated in the gas phase from bis(dibenzoylmethane) copper(II) (Cu(dbm)2) by laser desorption/ ionization (LDI) method. For example, the [Cu5dbm2(C6H5)2]+ ion can be considered as consisting of two Cudbm molecules, two CuC6H5 molecules and a Cu+ cation. The [Cu5(C6H5)4]+ ion can be considered as phenylcopper(I) cluster (consisting of four phenylcopper molecules) ionized by additional Cu+ cation. Results from MS/MS (tandem mass spectrometry) experiments have confirmed the presence of phenylcopper molecules in the analyzed clusters. Ease of preparation of dibenzoylmethane-metal complexes and straightforward method to obtain LDI mass spectra offer a wide range of possibilities to study similar organometallic clusters in the gas phase.
Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine
Authors: Bandari Suresh , Eaga Chandra , Thadishetty Ashok , Yamsani Madhusudan 
Published: March 2010

Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverineA biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L-1HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.
Design, synthesis, hydrolysis kinetics and phamacodynamic profiles of histidine and alanine conjugates of aceclofenac
Authors: Rasheed Arun , Kumar C. 
Published: March 2010

Design, synthesis, hydrolysis kinetics and phamacodynamic profiles of histidine and alanine conjugates of aceclofenacThe gastrointestinal toxicity associated with aceclofenac can be reduced by condensing its carboxylic acid group with methyl esters of amino acids like histidine and alanine to give amide linkage by the Schotten-Baumann method. Physicochemical characterization of the conjugates was carried out by various analytical and spectral methods. The synthesized conjugates were also subjected toin vitrohydrolysis in simulated gastric fluid (SGF) at pH 1.2, simulated intestinal fluid (SIF) at pH 7.4 and SIF+ 80% human plasma at pH 7.4. The release of free aceclofenac from histidine and alanine conjugated aceclofenac showed negligible hydrolysis in SGF compared to SIF. This indicated that the conjugates do not break in stomach, but release aceclofenac in SIF. Both synthesized conjugates showed excellent pharmacological response and encouraging hydrolysis rate in SIF and SIF + 80% human plasma. Marked reduction of the ulcer index and comparable increase in analgesic and anti-inflammatory activities were obtained in both cases compared to aceclofenac alone. These findings suggest that the conjugates are better in action compared to the parent drug and have fewer gastrointestinal side-effects.
New Records of Xylomycetobiontic Beetles (Insecta, Coleoptera) from Kyiv Region (Ukraine)
Authors: Krivosheyev R. 
Published: March 2010

New Records of Xylomycetobiontic Beetles (Insecta, Coleoptera) from Kyiv Region (Ukraine)
Eleven species are recorded from Kyiv and Kyiv Region, among them three, Corticarina latipennis (Sahlberg, 1871), Cis laricinus (Mellié, 1848), and Epuraea excisicollis (Reitter 1872), are recorded from Ukraine, Triplax rufipes (Fabricius, 1781) and Cis glabratus (Mellié, 1848) from Kyiv Region, and Salpingus ruficollis (Linnaeus, 1761) from the Left-Bank (Trans-Dnieper) Ukraine for the first time. Distribution and ecological peculiarities of some species are discussed.
The Fruit Flies (Diptera, Tephritidae) in Tehran Province, with New Records for Iranian Fauna
Authors: Namin S. , Nozari J. , Rasoulian Gh. 
Published: March 2010

The Fruit Flies (Diptera, Tephritidae) in Tehran Province, with New Records for Iranian FaunaAs the result of studies of the tephritid flies in Tehran Province (Iran) in 2008-2009, 38 species of 22 genera are found to occur in this region; altogether 47 species are listed; of them, 9 species and 2 genera (ChetostomaandXyphosia) are recorded for the first time for Iranian fauna. In addition,Steptorrhamphus tuberosusis reported as a new host plant forEnsina sonchi.
Serum Calprotectin as a Marker for Disease Activity and Severity in Adult-onset Still’s Disease
Authors: JUNG SANG-YOUN , PARK YONG-BEOM , HA YOU-JUNG , LEE KWANG-HOON , LEE SOO-KON 
Published: March 2010

Objective.Calprotectin is a calcium-binding cytosolic protein of the neutrophil, monocyte, and macrophage, and its secretion increases during activation of these cells. Our objective was to measure serum calprotectin concentrations in patients with adult-onset Still’s disease (AOSD) and to correlate serum calprotectin with the activity and severity of AOSD.Methods.We enrolled 25 patients with AOSD and 30 age- and sex-matched healthy controls. Thirty-one serum samples were obtained from patients with AOSD during active or inactive disease and were assayed for calprotectin by ELISA. Clinical and laboratory data related to disease activity and severity were collected at the same time, and systemic scores for disease severity were calculated.Results.Mean calprotectin levels in patients with AOSD were significantly higher than in controls (57.11 ± 25.38 ng/ml vs 34.90 ± 4.85 ng/ml, respectively; p < 0.05). Patients with active AOSD had a significantly higher mean calprotectin level than those with inactive disease (61.26 ± 25.59 ng/ml vs 35.32 ± 5.90 ng/ml; p < 0.05). Calprotectin levels decreased significantly after treatment in all 6 patients with AOSD from whom followup samples were obtained (p = 0.028). Serum calprotectin showed strong correlations with serum ferritin (r = 0.686, p < 0.001), lactate dehydrogenase (r = 0.647, p < 0.001), leukocyte count (r = 0.774, p < 0.001), aspartate aminotransferase (r = 0.387, p = 0.042), and C-reactive protein (r = 0.588, p = 0.001), but not with erythrocyte sedimentation rate, arginine aminotransferase, hemoglobin, or platelet count. Serum calprotectin showed a significant correlation with AOSD systemic scores, reflecting disease severity (r = 0.803, p < 0.001).Conclusion.Serum calprotectin increased in patients with AOSD, in close correlation with disease activity and severity. These findings suggest that serum calprotectin can provide a reliable clinical marker for monitoring the disease activity and severity of AOSD.
Lack of Association Between the rs6920220 (G/A) Polymorphism of the 6q23 Region and Biopsy-proven Giant Cell Arteritis
Authors: PALOMINO-MORALES ROGELIO , TORRES ORLANDO , VAZQUEZ-RODRIGUEZ TOMAS R. , CASTAÑEDA SANTOS , MORADO INMACULADA C. , MIRANDA-FILLOY JOSE A. , AMIGO-DIAZ ENCARNACION , CALLEJAS-RUBIO JOSE L. , FERNANDEZ-GUTIERREZ BENJAMIN , MARTIN JAVIER , GONZALEZ-GAY MIGUEL A. 
Published: March 2010

Objective.Recently, 2 independent studies have identified an association between several single-nucleotide polymorphisms (SNP) located in the 6q23 chromosomal region and rheumatoid arthritis (RA). Like RA, giant cell arteritis (GCA) is also a complex polygenic disease in which more than 1 genetic locus is likely to contribute to disease susceptibility and clinical expression. We analyzed the involvement of the rs6920220 (G/A) polymorphism from the6q23/TNFAIP3gene region in susceptibility to GCA.Methods.Two hundred twenty patients with biopsy-proven GCA and 490 matched controls were assessed. DNA from patients and controls was obtained from peripheral blood. Samples were geno-typed for the 6q23 region rs6920220 using a TaqMan allele discrimination assay and by polymerase chain reaction (PCR) amplification. After PCR, the genotype of each sample was attributed automatically by allelic-specific fluorescence using the ABI Prism 7900 sequence detection system.Results.No significant differences in the genotype distribution between patients with GCA and controls for the rs6920220 (G/A) polymorphism were found. No significant differences were observed when patients with GCA were stratified according to the presence of specific clinical features of the disease such as polymyalgia rheumatica or severe ischemic manifestations or specific visual ischemic complications.Conclusion.Our results show no involvement of this6q23/TNFAIP3gene region SNP in the susceptibility to or clinical expression of GCA.
Phenotype-Haplotype Correlation of IRF5 in Systemic Sclerosis: Role of 2 Haplotypes in Disease Severity
Authors: DIEUDE PHILIPPE , DAWIDOWICZ KAREN , GUEDJ MICKAËL , LEGRAIN YONA , WIPFF JULIEN , HACHULLA ERIC , DIOT ELISABETH , SIBILIA JEAN , MOUTHON LUC , CABANE JEAN , AMOURA ZAHIR , CRAKOWSKI JEAN-LUC , CARPENTIER PATRICK , AVOUAC JEROME , MEYER OLIVIER , KAHAN ANDRE , BOILEAU CATHERINE , ALLANORE YANNICK 
Published: March 2010

Objective.Identification of an association between IRF5 rs2004640 and systemic sclerosis (SSc) has highlighted a key role for type 1 interferon (IFN). Additional functional IRF5 variants have been identified as autoimmune susceptibility factors. Our aim was to investigate whether IRF5 haplotypes confer susceptibility to SSc, and to perform genotype haplotype-phenotype correlation analyses.Methods.We genotyped IRF5 rs377385, rs2004640, and rs10954213 in 1623 individuals of French European Caucasian origin. SSc patient subphenotypes were analyzed according to cutaneous subsets and for SSc-related pulmonary fibrosis.Results.Case-control studies of single markers revealed an association between IRF5 rs3757385, rs2004640, and rs10954213 variants and SSc. We identified an IRF5 risk haplotype “R” (padj = 0.024, OR 1.23, 95% CI 1.07–1.40) and a mirrored protective haplotype “P” (padj = 8.8 × 10−3, OR 0.78, 95% CI 0.68–0.90) for SSc susceptibility. Genotype-phenotype correlation analyses failed to detect any association with a single marker. By contrast, phenotype-haplotype correlation analysis was able to detect intra-cohort association and to discriminate SSc patients with from those without the following clinical traits: “R” and/or “P” haplotypes identified diffuse cutaneous SSc (p = 0.0081) and fibrosing alveolitis (p = 0.018).Conclusion.IRF5 haplotypes are more informative than single markers, suggesting that they could be helpful for risk stratification of SSc patients. Our study provides further evidence of a key role of IRF5 in SSc severity.
Characterization of Synergistic Induction of CX3CL1/Fractalkine by TNF-α and IFN-γ in Vascular Endothelial Cells: An Essential Role for TNF-α in Post-Transcriptional Regulation of CX3CL1
Authors: Matsumiya Tomoh , Ota Ken , Imaizumi Tadaatsu , Yoshida Hidemi , Kimura Hiroto , Satoh Kei 
Published: March 2010

Abstract
CX3CL1/Fractalkine, a chemokine specific to monocytes and NK cells, is induced synergistically by TNF-α and IFN-γ in vascular endothelial cells. However, the mechanism for this synergism remains unclear. This study explored the hypothesis that the CX3CL1 expression is regulated at a posttranscriptional level, which may responsible for the synergism between TNF-α and IFN-γ. Brief exposure of HUVECs to TNF-α led to a robust increase in IFN-γ–induced CX3CL1 production. We found that TNF-α stabilized CX3CL1 mRNA in HUVECs stimulated with IFN-γ. Cloning of 3′untranslated region (UTR) of CX3CL1 mRNA revealed the presence of a single copy of nonametric AU-rich element in its 3′UTR, and a luciferase reporter assay showed that a single AU-rich element is a crucial cis-element in the posttranscriptional regulation of CX3CL1. TNF-α treatment resulted in the phosphorylation of p38 MAPK and its downstream target, MAPK-activated protein kinase-2, but IFN-γ did not affect the levels of MAPK and MAPK-activated protein kinase-2 phosphorylation induced by TNF-α. Treatment of the cells with an inhibitor of p38 MAPK accelerated the decay of CX3CL1 mRNA induced by TNF-α or the combination of TNF-α and IFN-γ. Immunoprecipitation assay revealed that mRNA stabilizer HuR directly binds to 3′UTR of CX3CL1 mRNA. CX3CL1 expression is under control of posttranscriptional regulation, which is involved in the synergistic induction of CX3CL1 in response to the combined stimulation with TNF-α and IFN-γ.
IL-17RC Is Required for IL-17A– and IL-17F–Dependent Signaling and the Pathogenesis of Experimental Autoimmune Encephalomyelitis
Authors: Hu Yan , Ota Naruhisa , Peng Ivan , Refino Canio J. , Danilenko Dimitry M. , Caplazi Patrick , Ouyang Wenjun 
Published: March 2010

Abstract
It has been suggested that IL-17RC forms a complex with IL-17RA to mediate the functions of IL-17A and IL-17F homodimers as well as IL-17A/F heterodimers. It is still unclear whether IL-17RC is absolutely required for the signaling of IL-17 cytokines in vivo. By using Il-17rc–deficient mice, we show that IL-17RC is essential for the signaling of IL-17A, IL-17F, and IL-17A/F both in vitro and in vivo. IL-17RC does not preassociate with IL-17RA on the cell surface; rather IL-17A can induce the formation of an IL-17RC and IL-17RA complex. This process is not dependent on the intracellular similar expression to fibroblast growth factor genes and IL-17Rs (SEFIR) domain of IL-17RC, but the SEFIR is essential in IL-17A signal transduction. Finally, Il-17rc−/− mice develop much milder disease in an experimental autoimmune encephalomyelitis model, supporting an essential role for IL-17RC in mediating immune-mediated CNS inflammation.
Adaptive Interactions between HLA and HIV-1: Highly Divergent Selection Imposed by HLA Class I Molecules with Common Supertype Motifs
Authors: John Mina , Heckerman David , James Ian , Park Lawrence P. , Carlson Jonathan M. , Chopra Abha , Gaudieri Silvana , Nolan David , Haas David W. , Riddler Sharon A. , Haubrich Richard , Mallal Simon 
Published: March 2010

Abstract
Currently, 1.1 million individuals in the United States are living with HIV-1 infection. Although this is a relatively small proportion of the global pandemic, the remarkable mix of ancestries in the United States, drawn together over the past two centuries of continuous population migrations, provides an important and unique perspective on adaptive interactions between HIV-1 and human genetic diversity. HIV-1 is a rapidly adaptable organism and mutates within or near immune epitopes that are determined by the HLA class I genotype of the infected host. We characterized HLA-associated polymorphisms across the full HIV-1 proteome in a large, ethnically diverse national United States cohort of HIV-1–infected individuals. We found a striking divergence in the immunoselection patterns associated with HLA variants that have very similar or identical peptide-binding specificities but are differentially distributed among racial/ethnic groups. Although their similarity in peptide binding functionally clusters these HLA variants into supertypes, their differences at sites within the peptide-binding groove contribute to race-specific selection effects on circulating HIV-1 viruses. This suggests that the interactions between the HLA/HIV peptide complex and the TCR vary significantly within HLA supertype groups, which, in turn, influences HIV-1 evolution.