bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic venous disease of lower limbs in young men at high-altitude: A cross-sectional survey
Authors: Jiang Li , Wang Jun , Ma Lihong , Liu Shunbi , Li Yunming , Ding Sheng , Yang Xuelin , Liu Yuanzhang , He Siyi , Yan Hongtao 
Published: June 2024

Objectives The aim of this study was to understand the prevalence of chronic venous disease (CVD) of lower limbs in young men at high-altitude in Xizang, and to provide prevention measures. Methods The convenient sampling method was used to conduct a questionnaire survey among males aged 18 to 40 above an altitude of 3000 meters in Xizang in April 2023. The contents of the questionnaire included basic information, symptoms of CVD of lower limbs, protection status and training needs. Multivariate logistic regression model was calculated to evaluate the risk factors for CVD. Results A total of 350 survey questionnaires were received, and 326 valid samples were collected. The prevalence of CVD of lower limbs (C1-C6) was 37.42% (95%CI: 32.17%–42.68%), the ratio of C0 to C5 were 62.58%, 27.30%, 3.07%, 4.60%, 2.15% and 0.31%, respectively, no one reached C6. The top three symptoms of CVD were lower limb fatigue (18.10%), heaviness (15.34%) and pain (13.19%). 46.01% of respondents were unaware of CVD, and 12.88% of respondents did not have any protective measures of CVD. Multivariate logistic regression showed that age (OR = 1.076, 95%CI: 1.018–1.137, p = .009), preference for spicy food (OR = 1.747, 95%CI: 1.083–2.818, p = .022), unbalanced diet (OR = 1.877, 95%CI: 1.049–3.358, p = .034) and physical exercise (OR 0.610, 95%CI: 0.377–0.986, p = .044) were the independent risk factors for CVD. Conclusions This study provided data on the prevalence of CVD in young men at high-altitude and the risk factors for CVD. The findings of this study may facilitate the development of individualized clinical assessments and targeted prevention programs.
Association of Patient Satisfaction 2 Years After Hip Arthroscopy for Femoroacetabular Impingement Syndrome With Minimum 10-Year Patient-Reported Outcomes and Survivorship
Authors: Gilat Ron , Alvero Alexander B. , Vogel Michael J. , Nho Shane J. 
Published: June 2024

Background: Previous studies have shown that short-term outcomes after hip arthroscopy for femoroacetabular impingement syndrome (FAIS) predict midterm outcomes, but a limited number of studies have evaluated whether short-term outcomes predict long-term outcomes and survivorship. Purpose: To evaluate whether achieving clinically significant outcomes at 2 years after hip arthroscopy for FAIS can predict patient-reported outcomes (PROs) and survivorship at 10 years. Study Design: Cohort study; Level of evidence, 3. Methods: Patients who underwent primary hip arthroscopy for FAIS between June 2012 and December 2012 with a minimum 10-year follow-up were identified. Using previously established thresholds, we classified patients who achieved the 2-year Patient Acceptable Symptom State (PASS) for the visual analog scale (VAS) for satisfaction as the high satisfaction group and patients who did not as the low satisfaction group. Minimum 10-year PROs were then compared between the groups, including scores for the Hip Outcome Score (HOS)–Activities of Daily Living and –Sports Specific, the modified Harris Hip Score, the VAS for pain, and the VAS for satisfaction. Reoperation-free survivorship was compared. Results: Of 120 eligible consecutive patients, 85 patients were included (70.8% follow-up rate), of whom 61.2% were female. The mean age was 34.0 ± 12.8 years, and the mean body mass index was 25.4 ± 4.6. Of the 85 patients, 29 (34.1%) did not achieve PASS for the VAS for satisfaction at 2 years postoperatively compared with 56 (65.9%) who did. The low satisfaction group had significantly worse acetabular chondral grades at the time of surgery ( P = .008). At minimum 10-year follow-up, the high satisfaction group showed significantly better HOS-Activities of Daily Living, HOS-Sports Specific, modified Harris Hip Score, VAS pain, and VAS satisfaction scores ( P≤ .031). Compared with the low satisfaction group, the high satisfaction group had a significantly lower rate of secondary surgery (1.8% vs 24.1%, respectively; P = .002). Conclusion: Patients who achieved PASS for the VAS for satisfaction at 2 years after hip arthroscopy demonstrated superior minimum 10-year outcomes compared with patients who did not, including greater PRO scores and a higher survivorship rate. The high satisfaction group had lower grade acetabular cartilage damage at the time of surgery compared with those who did not achieve PASS for the VAS for satisfaction at 2 years.
Clinical Guidelines for the Treatment of Depressive Disorders VI. Special Populations
Authors: Thorpe Lilian , Whitney Diane K , Kutcher Stanley P , Kennedy Sidney H ,   The CANMAT Depression Work Group
Published: June 2024

Background: The Canadian Psychiatric Association and the Canadian Network for Mood and Anxiety Treatments partnered to produce clinical guidelines for psychiatrists for the treatment of depressive disorders. Methods: A standard guidelines development process was followed. Relevant literature was identified using a computerized Medline search supplemented by review of bibliographies. Operational criteria were used to rate the quality of scientific evidence. and the line of treatment recommendations included consensus clinical opinion. This section, “Special Populations, ” is I of 7 articles that were drafted and reviewed by clinicians. Revised drafts underwent national and international expert peer review. Results: This section reports on the prevalence, course, and outcome of depression for specific populations. Psychological, pharmacologic, and other biological treatment options for these populations—children and adolescents, the elderly, women at times of increased risk within the reproductive cyde, and specific ethnocultural groups—are critically evaluated. Conclusions: Major depressive disorder (MDD) is prevalent across the lifespan. In general, clinical presentations are more similar than different across age, sex, and cultural divides. Although less evidence is available for the efficacy of treatments in these subpopulations than in mid-life patients, comparable rates of response for pharmacotherapies, electroconvulsive therapy (ECT), and, in some cases, evidence-based psychotherapies have been reported.
Clinical Guidelines for the Treatment of Depressive Disorders VII. Comorbidity
Authors: Enns Murray W , Swenson J Robert , McIntyre Roger S , Swinson Richard P , Kennedy Sidney H ,   The CANMAT Depression Work Group
Published: June 2024

Background: The Canadian Psychiatric Association and the Canadian Network for Mood and Anxiety Treatments partnered to produce clinical guidelines for psychiatrists for the treatment of depressive disorders.Methods: A standard guidelines development process was followed. Relevant literature was identified using a computerized Medline search supplemented by review of bibliographies. Operational criteria were used to rate the quality of scientific evidence, and the line of treatment recommendations included consensus clinical opinion. This section, on Axis I, Axis II, and Axis III comorbidity, is 1 of 7 articles that were drafted and reviewed by clinicians. Revised drafts underwent national and international expert peer review.Results: Comorbid depression on Axis I is particularly prevalent in patients with anxiety disorders, substance use disorders, and eating disorders, but it also occurs in patients with schizophrenia, attention-deficit hyperactivity disorder (ADHD), and dementia. Depressive comorbidity has implications for assessment, management, and outcome. The relation between depression and personality disorders is complex. Patients with this comorbidity often require longer, more intense, and multimodal therapies. Depression is also prevalent in medical illnesses, requires careful diagnosis, and responds to standard antidepressant treatments.Conclusions: Comorbidity can influence the course and outcome of both associated conditions. Depression-specific psychotherapy and/or pharmacotherapy should be considered when comorbid depression is diagnosed.
Mitochondrial Impact of Organophosphate Pesticide-Induced Cardiotoxicity: An In Silico and In Vitro Study
Authors: Karakuş Fuat , Arzuk Ege , Ergüç Ali 
Published: June 2024

Organophosphate pesticides are widely used; however, their use is limited due to neurotoxicity and, to a lesser extent, cardiotoxicity in humans. Given the high energy demands of cardiac muscle, which is characterized by a dense population of mitochondria, any damage to these organelles can exacerbate cardiotoxicity. This study aims to elucidate whether the cardiotoxic effects of organophosphate pesticides originate from mitochondrial dysfunction. To investigate this, in silico toxicogenomic analyses were performed using various tools, such as the Comparative Toxicogenomic Database, GeneMANIA, STRING, and Cytoscape. Results revealed that 11 out of the 13 WHO-recommended Class Ia organophosphate pesticides target genes associated with cardiotoxicity. Notably, three of these genes were mitochondrial, with catalase (CAT) being the common differentially expressed gene among parathion, methyl parathion, and phorate. Furthermore, protein-protein interaction analysis indicated a strong association between CAT and superoxide dismutase 2, mitochondrial (SOD2). Subsequently, isolated heart mitochondria were utilized to assess CAT and superoxide dismutase (SOD) activities in vitro. The findings demonstrated that at a concentration of 7.5 ng/µL, both methyl parathion and phorate significantly decreased CAT activity by approximately 35%. Moreover, phorate reduced total SOD and SOD2 activities by 17% and 19%, respectively, at the same concentration. In contrast, none of the three organophosphate pesticides induced the opening of the mitochondrial permeability transition pore. These results suggest that the reduction in CAT and SOD2 activities, critical antioxidant enzymes, leads to the accumulation of reactive oxygen species within mitochondria, ultimately resulting in mitochondrial damage. This mechanism likely underlies the observed cardiotoxicity induced by these organophosphate pesticides.
13-Week Repeated Oral Toxicity and Toxicokinetic Studies of Rabeprazole Sodium and Sodium Bicarbonate Combination in Dogs
Authors: Roh Jae Seok , Nam Kyu-Yeol , Jung Won Tae , Kim Young-Min , Hwang Eui-Kyung , Jeon Tae-Won 
Published: June 2024

The subchronic toxicity and toxicokinetics of a combination of rabeprazole sodium and sodium bicarbonate were investigated in dogs by daily oral administration for 13 consecutive weeks with a 4-week recovery period. The dose groups consisted of control (vehicles), (5 + 200), (10 + 400), and (20 + 800) mg/kg of rabeprazole sodium + sodium bicarbonate, 20 mg/kg of rabeprazole sodium only, and 800 mg/kg of sodium bicarbonate only. Esophageal ulceration accompanied by inflammation was observed in only one animal in the male (20 + 800) mg/kg rabeprazole sodium + sodium bicarbonate group. However, the severity of the ulceration was moderate, and the site of occurrence was focally extensive; thus, it was assumed to be a treatment-related effect of rabeprazole sodium + sodium bicarbonate. In the toxicokinetics component of this study, systemic exposure to rabeprazole sodium (AUClast and Cmax at Day 91) was greater in males than females, suggesting sex differences. AUClast and Cmax at Day 91 were increased compared to those on Day 1 in a dose-dependent manner. A delayed Tmax and no drug accumulation were observed after repeated dosage. In conclusion, we suggest under the conditions of this study that the no-observed-adverse-effect level (NOAEL) of the combination of rabeprazole sodium + sodium bicarbonate in male and female dogs is (10 + 400) and (20 + 800) mg/kg, respectively.
Continuously monitoring the human machine? – A cross-sectional study to assess the acceptance of wearables in Germany
Authors: Hindelang Michael , Wecker Hannah , Biedermann Tilo , Zink Alexander 
Published: June 2024

Background: Wearables have the potential to transform healthcare by enabling early detection and monitoring of chronic diseases. This study aimed to assess wearables’ acceptance, usage, and reasons for non-use. Methods: Anonymous questionnaires were used to collect data in Germany on wearable ownership, usage behaviour, acceptance of health monitoring, and willingness to share data. Results: Out of 643 respondents, 550 participants provided wearable acceptance data. The average age was 36.6 years, with 51.3% female and 39.6% residing in rural areas. Overall, 33.8% reported wearing a wearable, primarily smartwatches or fitness wristbands. Men (63.3%) and women (57.8%) expressed willingness to wear a sensor for health monitoring, and 61.5% were open to sharing data with healthcare providers. Concerns included data security, privacy, and perceived lack of need. Conclusion: The study highlights the acceptance and potential of wearables, particularly for health monitoring and data sharing with healthcare providers. Addressing data security and privacy concerns could enhance the adoption of innovative wearables, such as implants, for early detection and monitoring of chronic diseases.
Investigating the effects of in-track countermeasures to reduce ground-borne vibration from underground railways
Authors: Shamayleh Hana YA , Hussien Mohammed FM 
Published: June 2024

In this research, the effects of two different types of in-track countermeasures on ground-borne vibration from underground railways are investigated. First, the influence of new type of supports is investigated, in which the rotation of the rail is partially or fully restrained. Second, a different simple local resonator is considered consisting of masses on springs placed at fixed spacing between the supports. To investigate the effects of these countermeasures, a numerical model is developed consisting of two sub-models: the first sub-model is an excitation model in which the track is modelled as an infinite beam on discrete supports connected to rigid foundation, for the calculations of forces transmitted to tunnel bed. The beam is analysed under the action of a number of axle masses with harmonic excitation induced through relative displacement between the un-sprung axle mass and the beam using a pull-through roughness. This first sub-model employs the dynamic stiffness method to perform the calculation. The second sub-model accounts for a tunnel embedded in a half space and is used to calculate the responses in the free surface with the input forces taken from the first sub-model after transformation to the wavenumber domain. The second sub-model is based on the well-known Pipe in Pipe (PiP) model. The discontinuously-supported model used in this work is verified using a continuously supported model. The effects of the suggested countermeasures on vibration mitigation are explored via parametric analysis that shows the impact of the added rotational stiffness, resonators’ natural frequency and the resonators’ mass. The results show for the parameters considered that using the rotation restrained support can effectively reduce the ground-borne vibration levels by up to 20 dB for low frequencies. Furthermore, the use of local resonators can reduce the ground-borne vibration by 4–10 dB for frequencies in the range 20–200 Hz.
Minding the body: A critical appraisal of three phenomenological accounts of embodiment in social work literature
Authors: Eriksson Karl 
Published: June 2024

Summary In the few social work publications dedicated to exploring phenomenological philosophical concepts, embodiment or the lived body, promoted especially by phenomenologist Maurice Merleau-Ponty, seems to have received special attention. Roughly, and according to a phenomenological philosophical perspective, the lived body signifies a mind–body unity that is believed to constitute acts of human perception, including social perception. This article aims to critically appraise three accounts of embodiment in social work literature, focusing on issues of application for the sake of clarifying the value and relevance of applied phenomenology in social work practice. After providing an overview of the reception of phenomenology in the social work literature, and introducing the three cases to be explored and their respective application of Merleau-Ponty's concept of the lived body, the article discusses Merleau-Ponty's own view on phenomenology, followed by a critical discussion of the three cases. Findings An applied phenomenology of embodiment turns out to be an ambiguous proposal, while simultaneously posing a challenge to the common-sense notion of professional reflection in face-to-face interaction between professional and client. The value of applying a phenomenology of embodiment to social work practice must arguably correspond to the question of how the lived body of the professional is disclosed reflectively in the encounter with other bodies, rather than simply how professionals adopt a theory to make sense of bodily experience at work. Applications This article contributes to clarifying the social situatedness of professional reflection, while also strengthening the case for phenomenological social work by exploring issues of application.
The Tanshinones (Tan) Extract From Salvia miltiorrhiza Bunge Induces ROS-Dependent Apoptosis in Pancreatic Cancer via AKT Hyperactivation-Mediated FOXO3/SOD2 Signaling
Authors: Xu Qin , Dong Shujie , Gong Qiuyi , Dai Qun , Cheng Rubin , Ge Yuqing 
Published: June 2024

Context: Salvia miltiorrhiza (SM) is a commonly used herb in traditional Chinese medicine (TCM) and has been used in the treatment of pancreatic cancer to relieve the symptom of “blood stasis and toxin accumulation.” Tanshinones (Tan), the main lipophilic constituents extracted from the roots and rhizomes of SM, have been reported to possess anticancer functions in several cancers. But the mechanism of how the active components work in pancreatic cancer still need to be clarified. Objective: In this study, we aimed to investigate the therapeutic potential of Tan in pancreatic cancer and elucidate the underlying mechanisms. Materials and Methods: The viabilities of PANC-1 and Bxpc-3 cells were determined by MTT assay, after treatment with various concentrations of Tan. The apoptotic cells were quantified by annexin V-FITC/PI staining and DAPI staining assays. The expression of relative proteins was used western blotting. Tumor growth was assessed by subcutaneously inoculating cells into C57BL/6 mice. Results: Our experiments discovered that Tan effectively suppressed pancreatic cancer cell proliferation and promoted apoptosis. Mechanistically, we propose that Tan enhances intracellular ROS levels by activating the AKT/FOXO3/SOD2 signaling pathway, ultimately leading to apoptosis in pancreatic cancer cells. In vivo assay showed the antitumor effect of Tan. Conclusion: Tan, a natural compound from Salvia miltiorrhiza, was found to effectively suppress pancreatic cancer cell proliferation and promote apoptosis both in vitro and in vivo. Mechanistically, we propose a positive feedback loop mechanism. These findings provide valuable insights into the molecular pathways driving pancreatic cancer progression.
Intensive Lifestyle Intervention for Cardiometabolic Prevention Implemented in Healthcare: Higher Risk Predicts Premature Dropout
Authors: Krachler Benno , Söderholm Anna , Ekman Fanny , Lindberg Frida , Lindbäck Joakim , Nilsson Sommar Johan , Glader Eva-Lotta , Lindahl Bernt 
Published: June 2024

Aims Patient characteristics and treatment setting are potential predictors of premature dropout from lifestyle interventions, but their relative importance is unknown. Methods From the quality registry of the unit for behavioral medicine, Umeå University hospital, we identified 2589 patients who had been enrolled in a multimodal lifestyle intervention for cardiometabolic risk reduction between 2006 and 2015. Baseline characteristics predicting dropout before 1-year follow-up were selected by a stepwise logistic regression algorithm. Results Better physical health and older age predicted full participation, with odds ratios for premature dropout (ORs) of .44 (95% confidence interval (CI) .31-.63), and .47 (95% CI .34-.65) in the highest compared to the lowest quartile, respectively. Odds of premature dropout were also lower among female participants, .71 (95% CI .58-.89). Premature dropout was predicted by higher BMI, snuffing tobacco, and smoking, with ORs of 1.53 (95% CI 1.13-2.08) in the highest compared to the lowest quartile of BMI, 1.37 (95% CI 1.03-1.81) comparing snuff user with non-users and 2.53 (95% CI 1.79-3.61) comparing smokers with non-smokers. Odds ratio for premature dropout among inpatients compared with outpatients was .84 (95% CI .68-1.04). Conclusion Higher risk at baseline predicts premature dropout.
Angiographic Safety and Efficacy of the ReSolv Flow-Diverting Stent in a Rabbit Model
Authors: Morrish Rosalie EA , Chunta Alec T , Belanger Brooke L , Croney Paige M , Salam M Suheel Abdul , Thompson Crista , Eesa Muneer , Wong John H , Mitha Alim P 
Published: June 2024

Background Bioresorbable polymer-based flow-diverting stents have potential benefits over existing metal devices. This study aimed to evaluate the safety and efficacy of the novel ReSolv device, which is a primarily polymer-based flow-diverting stent, using the in vivo rabbit sidewall saccular aneurysm model. Methods ReSolv stents were deployed in 14 New Zealand White rabbits that had undergone aneurysm creation procedures. Animals were allocated to follow-up time points of 1, 3, 6, 9, 12, 16, or 18 months. Angiographic images were evaluated by an independent neurointerventionalist blinded to follow-up time points for (1) in-stent stenosis, (2) parent vessel and jailed side branch patency, (3) wall apposition, and (4) aneurysm occlusion using the Raymond-Roy Occlusion Classification (RROC), O’Kelly Marotta grading scale, and the 4F flow diversion predictive score. Primary efficacy outcome was defined as RROC Class I or II. Results At a median follow-up time of 7.5 months, parent vessel (14/14) and jailed side (33/33) branches were patent in all cases. There was no development of thrombus on the stent or cases of significant in-stent stenosis, and all stents had good wall apposition. Adequate occlusion was found in 85.7% ( n = 12) of animals, including an RROC Class I in 64.3% ( n = 9) and RROC Class II in 21.4% ( n = 3). Conclusions The ReSolv stent shows encouraging angiographic safety and efficacy outcomes after placement in a rabbit sidewall saccular aneurysm model. Longer term studies are ongoing to determine eventual fate of the aneurysm, parent vessel, and jailed side branches after absorption of the polymer component of the stent.