bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sphingosine‐1‐phosphate activates chemokine‐promoted myeloma cell adhesion and migration involving α4β1 integrin function
Authors: García‐Bernal David , Redondo‐Muñoz Javier , Dios‐Esponera Ana , Chèvre Raphaël , Bailón Elvira , Garayoa Mercedes , Arellano‐Sánchez Nohemí , Gutierrez Norma C , Hidalgo Andrés , García‐Pardo Angeles , Teixidó Joaquin 
Published: June 2012

AbstractMyeloma cell adhesion dependent on α4β1 integrin is crucial for the progression of multiple myeloma (MM). The α4β1‐dependent myeloma cell adhesion is up‐regulated by the chemokine CXCL12, and pharmacological blockade of the CXCL12 receptor CXCR4 leads to defective myeloma cell homing to bone marrow (BM). Sphingosine‐1‐phosphate (S1P) regulates immune cell trafficking upon binding to G‐protein‐coupled receptors. Here we show that myeloma cells express S1P1, a receptor for S1P. We found that S1P up‐regulated the α4β1‐mediated myeloma cell adhesion and transendothelial migration stimulated by CXCL12. S1P promoted generation of high‐affinity α4β1 that efficiently bound the α4β1 ligand VCAM‐1, a finding that was associated with S1P‐triggered increase in talin‐β1 integrin association. Furthermore, S1P cooperated with CXCL12 for enhancement of α4β1‐dependent adhesion strengthening and spreading. CXCL12 and S1P activated the DOCK2‐Rac1 pathway, which was required for stimulation of myeloma cell adhesion involving α4β1. Moreover, in vivo analyses indicated that S1P contributes to optimizing the interactions of MM cells with the BM microvasculture and for their lodging inside the bone marrow. The regulation of α4β1‐dependent adhesion and migration of myeloma cells by CXCL12‐S1P combined activities might have important consequences for myeloma disease progression. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Synthesis, thermal polymerization, and properties of benzoxazine resins containing fluorenyl moiety
Authors: Fu Zien , Liu Huan , Cai Hualun , Liu Xin , Ying Guo , Xu Kai , Chen Mingcai 
Published: June 2012

AbstractThree difunctional fluorene‐based benzoxazine compounds were synthesized via Mannich condensation and were characterized by proton nuclear magnetic resonance spectroscopy (1H NMR), Fourier transform infrared spectroscopy (FTIR), and elementary analysis (EA). The polymerization of benzoxazine monomers were investigated with differential scanning calorimeter (DSC) method. Thermal properties of the polybenzoxazines were studied by thermogravimetric analysis (TGA) and DSC. Water absorption of the polybenzoxazines was tested. Contact angle measurement was employed to characterize the surface property of materials. The glass transition temperatures (Tgs) and thermal stability were improved significantly in comparison with bisphenol‐A‐based analogue because of the incorporation of rigid fluorenyl group. The fluorenyl‐based polybenzoxazines showed hydrophobic characteristics, which was ascribed to the low polarity of fluorenyl and pi–pi stacking interaction of fluorenyl on the surface. POLYM. ENG. SCI., 2012. © 2012 Society of Plastics Engineers
Effect of titanium dioxide nanoparticles on polydimethylsiloxane/polyethersulfone composite membranes for gas separation
Authors: Madaeni S.S. , Badieh M. Moahamadi Sarab , Vatanpour V. , Ghaemi N. 
Published: June 2012

AbstractIntroducing inorganic nanoparticles into the structure of polymeric membranes is an interesting approach for the enhancement of physical, chemical, and separation properties of the membranes. In this article, the performance of a two‐layer nanocomposite membrane for gas separation was studied. Three different methods for embedding titanium dioxide (TiO2) nanoparticle were employed for the membrane preparation. The techniques include blending TiO2 in the polydimethylsiloxane (PDMS) coating layer, blending TiO2 in the polyethersulfone (PES) support and dip coating of PES support with TiO2 accompanied by PDMS coating. The aim of the current research was finding the optimum technique for introducing TiO2 into the membrane to obtain superior performance for gas separation. The results indicated that PES support containing TiO2 nanoparticles possessed favorable effect on gas separation capability. The optimum performance was obtained by PDMS‐coated membranes prepared with 7 wt% TiO2‐embedded PES support. Carbon dioxide (CO2) permeance, CO2/nitrogen, and CO2/methane selectivity were obtained as 188.7 GPU, 8.6, and 3.4, respectively. POLYM. ENG. SCI., 2012. © 2012 Society of Plastics Engineers
Stretch‐induced molecular ordering in amorphous/crystalline polylactide blends
Authors: Lv Ruihua , Zou Shufen , Na Bing , Pan Huayan , Deng Huiyu 
Published: June 2012

AbstractThe effect of amorphous poly(D,L‐lactide) (PDLLA) on the molecular orientation and crystallization of crystalline poly(L‐lactide) (PLLA) on stretching is reported in this study. It is indicated that the presence of PDLLA in its miscible blends with PLLA is not favorable for either cohesive mesophase formation below Tg or strain‐induced crystallization above Tg at strains beyond the segmental extensibility limit. Because of lack of constraints imposed by cohesive mesophase or crystals, oriented segments are liable to slide each other or recoil, responsible for low‐molecular orientation in the stretched blends. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
Preparation of 1,3‐Diazido‐2‐Nitro‐2‐Azapropane from Urea
Authors: Il'yasov Sergey G. , Danilova Elena O. 
Published: June 2012

AbstractAn alternative method to prepare 1,3‐diazido‐2‐nitro‐2‐azapropane (DANP), a promising liquid component for high‐energy condensed systems, is suggested and involves the following stages: (i) nitration of urea, (ii) condensation of the nitration product with formaldehyde, (iii) acylation (chlorination) of 1,3‐dihydroxy‐2‐nitro‐2‐azapropane, (iv) chlorination of 1,3‐diacetoxy‐2‐nitro‐2‐azapropane, and (v) azidation of the dichloro derivative to DANP. This synthesis method is selective and enables isolation of 1,3‐diazido‐2‐nitrazapropane devoid of impurities.
A novel set of β‐N‐biaryl ether sulfonamide hydroxamates as potential MMPs inhibitors: Molecular dynamics simulations and molecular properties evaluation
Authors: Turra Kely Medeiros , Pasqualoto Kerly Fernanda Mesquita , de Moraes Barros Silvia Berlanga 
Published: June 2012

AbstractMatrix metalloproteinases (MMPs) constitute a family of zinc‐dependent proteases involved in the extracellular matrix degradation. MMP‐2 and MMP–9 are overexpressed in several human cancer types, including melanoma, thus the development of new compounds to inhibit MMPs' activity is desirable. Molecular dynamic simulation and molecular properties calculations were performed on a set of novel β‐N‐biaryl ether sulfonamide‐based hydroxamates, reported as MMP‐2 and MMP‐9 inhibitors, for providing data to develop an exploratory analysis. Thermodynamic, electronic, and steric descriptors have significantly discriminated highly active from moderately and less active inhibitors of MMP‐2 whereas apparent partition coefficient at pH 1.5 was also significant for the MMP‐9 data set. Compound 47 was considered an outlier in all analysis, indicating the presence of a bulky substituent group in R3 is crucial to this set of inhibitors for the establishment of molecular interactions with the S1 subsite of both enzymes, but there is a limit. © 2012 Wiley Periodicals, Inc.
Hydrogen site occupation and electronic structure in the La2Ni2In intermetallic and hydrides
Authors: Aburto Andrea , Orgaz Emilio 
Published: June 2012

AbstractBy means of electronic structure computation methods based on density functional theory, we investigated some properties of the intermetallic compounds R2Ni2In (R = La, Ce, Pr, Nd). We studied the hydrogen atom occupancy in the La2Ni2In intermetallic and we found that the available interstitial sites for hydrogen occupation can be clearly differentiated by the hydrogen site energy. Hydrogen atoms are stabilized by the NiH bonding interaction. This result indicates that the formation of a solid solution and eventually a hydride phase follow an enthalpic controlled order. With this information, we have investigated the formation of hydride phases in La2Ni2In. © 2012 Wiley Periodicals, Inc.
Information geometric security analysis of differential phase‐shift quantum key distribution protocol
Authors: Gyongyosi Laszlo , Imre Sandor 
Published: June 2012

ABSTRACTThis paper analyzes the information‐theoretical security of the of Differential Phase Shift (DPS) Quantum Key Distribution (QKD) protocol, using efficient computational information geometric algorithms. The protocol was introduced for practical reasons, since the earlier QKD schemes were too complicated to implement in practice. The DPS QKD protocol can be an integrated part of current network security applications; hence its practical implementation is much easier with the current optical devices and optical networks. The proposed algorithm could be a very valuable tool to answer the still open questions related to the security bounds of the DPS QKD protocol. Copyright © 2012 John Wiley & Sons, Ltd.
Decentralized model predictive‐based load‐frequency control in an interconnected power system concerning wind turbines
Authors: Mohamed Tarek Hassan , Morel Jorge , Bevrani Hassan , Abd‐Eltawwab Hassan Ahmed , Sayed Mohamed Yehia , Hiyama Takashi 
Published: June 2012

AbstractThis paper presents a load‐frequency control (LFC) design using the model predictive control (MPC) technique in a multi‐area power system in the presence of wind turbines (WTs). In the studied system, the controller of each local area is designed independently such that the stability of the overall closed‐loop system is guaranteed. A frequency response model of the multi‐area power system including WTs is introduced, and physical constraints of the governors and turbines are considered. The model was employed in the MPC structures. Digital simulations for a two‐area power system are provided to validate the effectiveness of the proposed scheme. The results show that with the proposed MPC technique the overall closed‐loop system performance shows robustness in the face of uncertainties due to governor and turbine parameter variation and load disturbances. A performance comparison between the proposed controller with WTs and MPC without WTs and a classical integral control scheme is carried out, confirming the superiority of the proposed MPC technique with WTs. © 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Augmented automatic choosing control of filter type for nonlinear systems and its application to power systems
Authors: Takata Hitoshi , Hachino Tomohiro , Motoyama Seiji , Yunokuchi Kazutomo , Kawabata Kimihisa 
Published: June 2012

AbstractThis paper deals with a feedback control using automatic choosing control and nonlinear filter for nonlinear systems with noise measurement. The state estimation of plants is carried out by the nonlinear filter. The control is designed by piecewise linear controls which are smoothly integrated into a single nonlinear feedback control by the automatic choosing functions. This is called an augmented automatic choosing control of filter type (AACCF) for nonlinear noisy measurement systems. This controller is applied to a transient stability problem of power systems, whose simulation results show that the new controller enables the expansion of the stable region well. © 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
A novel and simple model for estimating the hourly global solar radiation
Authors: Zang Haixiang , Xu Qingshan , Ichiyanagi Katsuhiro 
Published: June 2012

AbstractThis letter proposes a novel and simple method for estimating solar radiation, named the ‘three‐point method’. The three points used to form the model are sunrise, sunset, and the maximum radiation point. The issue of obtaining maximum radiation is performed with the weighting evaluation of the HOTTEL and ASHRAE models. The feasibility and effectiveness of the proposed model is shown by simulation results. This model is equally applicable in any part of the world with a reassessment of the weighting factors for the maximum radiation. © 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
The 22q11 deletion: DiGeorge and velocardiofacial syndromes and the role of TBX1
Authors: Papangeli Irinna , Scambler Peter 
Published: June 2012

AbstractHemizygous deletion of 22q11 affects approximately 1:4000 live births and may give rise to many different malformations but classically results in a constellation of phenotypes that receive a diagnosis of DiGeorge syndrome or velocardiofacial syndrome. Particularly affected are the heart and great vessels, the endocrine glands of the neck, the face, the soft palate, and cognitive development. Although up to 50 genes may be deleted, it is haploinsufficiency of the transcription factor TBX1 that is thought to make the greatest contribution to the disorder. Mouse embryos are exquisitely sensitive to varying levels of Tbx1 mRNA, and Tbx1 is required in all three germ layers of the embryonic pharyngeal region for normal development. TBX1 controls cell proliferation and affects cellular differentiation in a cell autonomous fashion, but it also directs non‐cell autonomous effects, most notably in the signaling between pharyngeal surface ectoderm and the rostral neural crest. TBX1 interacts with several signaling pathways, including fibroblast growth factor, retinoic acid, CTNNB1 (formerly known as β‐catenin), and bone morphogenetic protein (BMP), and may regulate pathways by both DNA‐binding and non‐binding activity. In addition to the structural abnormalities seen in 22q11 deletion syndrome (DS) and Tbx1 mutant mouse models, patients reaching adolescence and adulthood have a predisposition to psychiatric illness. Whether this has a developmental basis and, if so, which genes are involved is an ongoing strand of research. Thus, knowledge of the genetic and developmental mechanisms underlying 22q11DS has the potential to inform about common disease as well as developmental defect. WIREs Dev Biol 2013, 2:393–403. doi: 10.1002/wdev.75For further resources related to this article, please visit the WIREs website.
The Caenorhabditis elegans epidermis as a model skin. II: differentiation and physiological roles
Authors: Chisholm Andrew D. , Xu Suhong 
Published: June 2012

AbstractThe Caenorhabditis elegans epidermis forms one of the principal barrier epithelia of the animal. Differentiation of the epidermis begins in mid embryogenesis and involves apical–basal polarization of the cytoskeletal and secretory systems as well as cellular junction formation. Secretion of the external cuticle layers is one of the major developmental and physiological specializations of the epidermal epithelium. The four post‐embryonic larval stages are separated by periodic moults, in which the epidermis generates a new cuticle with stage‐specific characteristics. The differentiated epidermis also plays key roles in endocrine signaling, fat storage, and ionic homeostasis. The epidermis is intimately associated with the development and function of the nervous system, and may have glial‐like roles in modulating neuronal function. The epidermis provides passive and active defenses against skin‐penetrating pathogens and can repair small wounds. Finally, age‐dependent deterioration of the epidermis is a prominent feature of aging and may affect organismal aging and life span. WIREs Dev Biol 2012 doi: 10.1002/wdev.77This article is categorized under:

Early Embryonic Development > Development to the Basic Body Plan
Invertebrate Organogenesis > Worms
Storage Age of Transfused Red Blood Cells During Liver Transplantation and Its Intraoperative and Postoperative Effects
Authors: Chen Jun , Singhapricha Terry , Memarzadeh Masood , Ziman Alyssa , Yuan Shan , Hu Ke‐qin , Steadman Randolph H. , Busuttil Ronald W. , Xia Victor W. 
Published: June 2012

AbstractBackgroundRecent studies suggest that the storage age of red blood cells (RBCs) may be associated with morbidity and mortality in surgical patients. We studied perioperative effects of RBC storage age in patients undergoing orthotopic liver transplant (OLT).MethodsAdult patients who received ≥5 U of RBCs during OLT between January 2004 and June 2009 were studied. The subjects were divided into two groups according to the mean storage age of RBCs they received: new or old RBCs (stored ≤14 or >14 days, respectively). Effects of storage age of transfused RBCs during OLT on intraoperative potassium (K+) concentrations, incidence of hyperkalemia (K+ ≥5.5 mmol/L), postoperative morbidity, and patient and graft survival were studied.ResultsThe mean serum K+ concentrations and the incidence of hyperkalemia during OLT were significantly associated with storage age of the RBCs. Logistic analysis showed that storage age of RBCs was an independent risk factor for intraoperative hyperkalemia (odds ratios 1.067–1.085, p < 0.001) in addition to baseline K+ concentration and units of RBCs transfused. Patient and graft survival and postoperative morbidity including postoperative ventilation, reoperation, acute renal dysfunction defined by the RIFLE criteria was not associated with old RBCs.ConclusionsTransfusion of RBCs stored for a longer time was associated with intraoperative hyperkalemia but not with postoperative adverse outcomes in adult OLT. Prevention and treatment of potentially harmful hyperkalemia should be considered when old RBCs are administered.
Substituted Thiadiazole, Oxadiazole, Triazole and Triazinone as Antimicrobial and Surface Activity Compounds
Authors: El‐Sayed R. 
Published: June 2012

AbstractStearic acid (1) was utilized as a new cheap starting material in the manufacture of important biologically active heterocycles as thiadiazole, oxadiazole, triazole and triazinone derivatives (2–11) by treating with different nucleophiles. These heterocycles bears active hydrogen atom (SH, NH and NH2) which could be propoxylated by different moles of propylene oxide (5, 10, 15 mol) to produce nonionic compounds (12–21)a–c having functions as surface and antimicrobial activities. The structural elucidation of these compounds is based on IR, 1H NMR, 13C NMR and elemental analysis. The surface properties (surface and interfacial tension, cloud point, witting time, foaming properties and emulsion stability) and the biodegradability were screened beside these compounds have been tested for their antimicrobial activity.
The imbibing idiot bias: Consuming alcohol can be hazardous to your (perceived) intelligence
Authors: Rick Scott I. , Schweitzer Maurice E. 
Published: June 2012

AbstractAlcohol consumption and cognitive impairment frequently co‐occur. We propose that the relationship is so familiar that exposure to alcohol cues primes expectations of cognitive impairment. Across five studies, we find that in the absence of any evidence of reduced cognitive performance, people who hold an alcoholic beverage are perceived to be less intelligent than those who do not, a mistake we term the imbibing idiot bias. In fact, merely priming observers with alcohol cues causes them to judge targets who hold no beverage at all as less intelligent. The bias is not driven by a belief that less intelligent people are more likely to consume alcohol. We find that the bias may be costly in professional settings. Job candidates who ordered wine during an interview held over dinner were viewed as less intelligent and less hireable than candidates who ordered soda. However, prospective candidates believe that ordering wine rather than soda will help them appear more intelligent.
President Obama and Gay Rights: The 2008 and 2012 Presidential Elections
Authors: McThomas Mary , Buchanan Robert J. 
Published: June 2012

AbstractWe examine the role and potential impact of gay, lesbian, and bisexual (GLB) voters in the 2008 and 2012 presidential elections. We look at trend data from 1990 to 2010 to assess the fluctuations in support for the Democratic Party by GLB voters, specifically a substantial decrease in support during the 2010 midterm elections. We use data from the 2008 election to assess the estimated contribution the GLB vote made toward President Obama's margin of victory in key battleground states. Looking at the Obama administration's record on gay rights, specifically the failure to pass the Employment Non-Discrimination Act (ENDA), we argue that the Democratic Party could be held accountable in the 2012 election for their failure to provide protection from employment discrimination based on sexual orientation. Potentially the 2012 election will be closer than the 2008 race, highlighting the importance of the GLB vote to President Obama's reelection in key states. We argue that if President Obama incorporates strong support for ENDA into his reelection platform, the Democratic Party has the chance to recapture the GLB votes it lost in 2010 and maintain enough of the 2008 electoral votes that led to President Obama's victory.
Growing Social Inequalities in Youth Civic Engagement? Evidence from the National Election Study
Authors: Wray-Lake Laura , Hart Daniel 
Published: June 2012

AbstractSocial class differences in civic engagement persist for both youth and adults. Although empirical evidence is mixed, several recent social changes pertaining to youth suggest that social inequalities in civic engagement may be growing over time for young people. Using data from the National Election Study, we compared trends for youth and older adults of varying education levels and tested the hypothesis of an increasing educational disparity in youth political participation. Results for voting supported our expectations: declines over time were found for less-educated youth only. Unexpectedly, participation in other political activities for more-educated youth declined more over time compared to other groups. Our findings highlight the need to create equal opportunities for youth civic engagement across social groups.
Don't Know Much about Democracy: Reporting Survey Data with Nonsubstantive Responses
Authors: Reilly Jonathan , Zigerell L. J 
Published: June 2012

AbstractLarge majorities in nearly every country support democracy, according to studies of cross-national surveys. But many of these reports have treated as missing data persons who did not provide a substantive response when asked to offer an opinion about the suitability of democracy as a regime type for their country, which has led to substantial overestimates of expressed support for democracy in some countries. This article discusses the consequences of excluding such nonsubstantive responses and offers suggestions to improve the study of popular support for democracy.
Predicting Rank Attainment in Political Science: What Else Besides Publications Affects Promotion?
Authors: Hesli Vicki L. , Lee Jae Mook , Mitchell Sara McLaughlin 
Published: June 2012

AbstractWe report the results of hypotheses tests about the effects of several measures of research, teaching, and service on the likelihood of achieving the ranks of associate and full professor. In conducting these tests, we control for institutional and individual background characteristics. We focus our tests on the link between productivity and academic rank and explore whether this relationship reveals a gender dimension. The analyses are based on an APSA-sponsored survey of all faculty members in departments of political science (government, public affairs, and international relations) in the United States.