bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesoscale Simulation of Tropical Cyclones in the South Pacific: Climatology and Interannual Variability
Authors: Jourdain Nicolas C. , Marchesiello Patrick , Menkes Christophe E. , Lefèvre Jérome , Vincent Emmanuel M. , Lengaigne Matthieu , Chauvin Fabrice 
Published: January 2011

Abstract
The Weather Research and Forecast model at ⅓° resolution is used to simulate the statistics of tropical cyclone (TC) activity in the present climate of the South Pacific. In addition to the large-scale conditions, the model is shown to reproduce a wide range of mesoscale convective systems. Tropical cyclones grow from the most intense of these systems formed along the South Pacific convergence zone (SPCZ) and sometimes develop into hurricanes. The three-dimensional structure of simulated tropical cyclones is in excellent agreement with dropsondes and satellite observations. The mean seasonal and spatial distributions of TC genesis and occurrence are also in good agreement with the Joint Typhoon Warning Center (JTWC) data. It is noted, however, that the spatial pattern of TC activity is shifted to the northeast because of a similar bias in the environmental forcing. Over the whole genesis area, 8.2 ± 3.5 cyclones are produced seasonally in the model, compared with 6.6 ± 3.0 in the JTWC data. Part of the interannual variability is associated with El Niño–Southern Oscillation (ENSO). ENSO-driven displacement of the SPCZ position produces a dipole pattern of correlation and results in a weaker correlation when the opposing correlations of the dipole are amalgamated over the entire South Pacific region. As a result, environmentally forced variability at the regional scale is relatively weak, that is, of comparable order to stochastic variability (±1.7 cyclones yr−1), which is estimated from a 10-yr climatological simulation. Stochastic variability appears essentially related to mesoscale interactions, which also affect TC tracks and the resulting occurrence.
Effects of Relative and Absolute Sea Surface Temperature on Tropical Cyclone Potential Intensity Using a Single-Column Model
Authors: Ramsay Hamish A. , Sobel Adam H. 
Published: January 2011

Abstract
The effects of relative and absolute sea surface temperature (SST) on tropical cyclone potential intensity are investigated using the Massachusetts Institute of Technology (MIT) single-column model. The model is run in two modes: (i) radiative–convective equilibrium (RCE) to represent the convective response to uniform warming of the ocean as in a homogeneous aqua planet, and (ii) weak temperature gradient (WTG) to represent the convective response to warming over a limited area of ocean while the SST outside that area remains unchanged. The WTG calculations are taken to represent the sensitivity of the atmospheric state to relative SST changes, while the RCE calculations are taken to represent the sensitivity to absolute SST changes occurring in the absence of relative SST changes. The potential intensity is computed using temperature and moisture profiles from the two sets of experiments for various values of SST. The computed potential intensity is more sensitive to relative SST than to absolute SST, with slopes of between about 7 and 8 m s−1 °C−1 (depending on choice of input parameters in the model’s convection scheme and other details of the model configuration) in the WTG calculations and about 1 m s−1 °C−1 in RCE. The sensitivity to relative SST obtained from these calculations is quantitatively similar to that obtained previously by G. Vecchi and B. J. Soden from global climate model output. The greater sensitivity of potential intensity to SST in the WTG simulations (relative to RCE) can be attributed primarily to larger changes in the air–sea thermodynamic disequilibrium in those calculations as SST changes, which results from the inability of the free troposphere to adjust to the SST in WTG as it does in RCE.
On the Significance of the Sensible Heat Supply from the Ocean in the Maintenance of the Mean Baroclinicity along Storm Tracks
Authors: Hotta Daisuke , Nakamura Hisashi 
Published: January 2011

Abstract
The relative importance between the sensible heat supply from the ocean and latent heating is assessed for the maintenance of near-surface mean baroclinicity in the major storm-track regions, by analyzing steady linear responses of a planetary wave model to individual components of zonally asymmetric thermal forcing taken from a global reanalysis dataset. The model experiments carried out separately for the North Atlantic, North Pacific, and south Indian Oceans indicate that distinct local maxima of near-surface baroclinicity observed along the storm tracks can be reinforced most efficiently as a response to the near-surface sensible heating. The result suggests the particular importance of the differential sensible heat supply from the ocean across an oceanic frontal zone for the efficient restoration of surface baroclinicity, which acts against the relaxing effect by poleward eddy heat transport, setting up conditions favorable for the recurrent development of transient eddies to anchor a storm track. Unlike what has been suggested, the corresponding reinforcement of the near-surface baroclinicity along a storm track as the response to the latent heating due either to cumulus convection or large-scale condensation is found less efficient. As is well known, poleward eddy heat flux convergence acts as the primary contributor to the reinforcement of the surface westerlies, especially in the core of a storm track. In its exit region, a substantial contribution to the reinforcement arises also from a planetary wave response to the sensible heat supply from the ocean. In contrast, the surface wind acceleration as a planetary wave response to the latent heating is found to contribute negatively to the maintenance of the surface westerlies along any of the major storm tracks.
Weather Regimes in the Euro-Atlantic and Mediterranean Sector, and Relationship with West African Rainfall over the 1989–2008 Period from a Self-Organizing Maps Approach
Authors: Polo Irene , Ullmann Albin , Roucou Pascal , Fontaine Bernard 
Published: January 2011

Abstract
Weather regimes (WRs) have been defined over the Euro-Mediterranean region (15°–70°N, 60°W–60°E) from May to October using the daily sea level pressure, 700-hPa geopotential height, and specific humidity from the European Centre for Medium-Range Weather Forecasts Re-Analysis (ERA)-Interim over the 1989–2008 period. Computations are based on a neural network classification technique referred to as self-organizing maps, and the WRs produced can be used by the scientific community for comparison with other periods, projection onto model outputs, seasonal prediction, or teleconnection studies. The article particularly examines the relationship between WRs and West Africa (WA) rainfall, and the study’s results suggest that changes in particular WR frequencies can account for a part of the WA’s interannual rainfall variability. Thus, during anomalous wet (dry) years in WA rainfall, both more occurrences of WRs related to the negative (positive) summer North Atlantic Oscillation (NAO)–like pattern and fewer occurrences of WRs related to the positive (negative) summer NAO-like pattern are attested in July and August (SN− and SN+, respectively). This is associated with a zonal symmetric pattern, consistent along the midtroposphere—that is, a low pressure anomaly centered over 50°N, 20°W and Eurasia (Greenland) and a high pressure anomaly centered over Iceland (central Europe) for SN− (SN+). Another striking characteristic of SN− (SN+) are southeastward (southwestward) anomalous surface winds flowing from (to) the Atlantic Ocean at 20°N; therefore able to enhance (weaken) wet convection. That sea surface temperature associated with SN− shows a warming of the Mediterranean in July and the opposite with SN+ in August suggests that temperature anomalies could be a precursor in the change of frequency of SN− and SN+.
Intensification of Precipitation Extremes with Warming in a Cloud-Resolving Model
Authors: Muller Caroline J. , O’Gorman Paul A. , Back Larissa E. 
Published: January 2011

Abstract
A cloud-resolving model is used to investigate the effect of warming on high percentiles of precipitation (precipitation extremes) in the idealized setting of radiative-convective equilibrium. While this idealized setting does not allow for several factors that influence precipitation in the tropics, it does allow for an evaluation of the response of precipitation extremes to warming in simulations with resolved rather than parameterized convection. The methodology developed should also be applicable to less idealized simulations.
Modeled precipitation extremes are found to increase in magnitude in response to an increase in sea surface temperature. A dry static energy budget is used to relate the changes in precipitation extremes to changes in atmospheric temperature, vertical velocity, and precipitation efficiency. To first order, the changes in precipitation extremes are captured by changes in the mean temperature structure of the atmosphere. Changes in vertical velocities play a secondary role and tend to weaken the strength of precipitation extremes, despite an intensification of updraft velocities in the upper troposphere. The influence of changes in condensate transports on precipitation extremes is quantified in terms of a precipitation efficiency; it does not change greatly with warming.
Tropical precipitation extremes have previously been found to increase at a greater fractional rate than the amount of atmospheric water vapor in observations of present-day variability and in some climate model simulations with parameterized convection. But the fractional increases in precipitation extremes in the cloud-resolving simulations are comparable in magnitude to those in surface water vapor concentrations (owing to a partial cancellation between dynamical and thermodynamical changes), and are substantially less than the fractional increases in column water vapor.
Influence of Karst Landscape on Planetary Boundary Layer Atmosphere: A Weather Research and Forecasting (WRF) Model–Based Investigation
Authors: Leeper Ronnie , Mahmood Rezaul , Quintanar Arturo I. 
Published: January 2011

AbstractKarst hydrology provides a unique set of surface and subsurface hydrological components that affect soil moisture variability. Over karst topography, surface moisture moves rapidly below ground via sink holes, vertical shafts, and sinking streams, reducing surface runoff and moisture infiltration into the soil. In addition, subsurface cave blockage or rapid snowmelt over karst can lead to surface flooding. Moreover, regions dominated by karst may exhibit either drier or wetter soils when compared to nonkarst landscape. However, because of the lack of both observational soil moisture datasets to initialize simulations and regional land surface models (LSMs) that include explicit karst hydrological processes, the impact of karst on atmospheric processes is not fully understood. Therefore, the purpose of this study was to investigate the importance of karst hydrology on planetary boundary layer (PBL) atmosphere using the Weather Research and Forecasting Model (WRF). This research is a first attempt to identify the impacts of karst on PBL. To model the influence of karst hydrology on atmospheric processes, soil moisture was modified systematically over the Western Kentucky Pennyroyal Karst (WKYPK) region to produce an ensemble of dry and wet anomaly experiments. Simulations were conducted for both frontal- and nonfrontal-based convection. For the dry ensemble, cloud cover was both diminished downwind of karst because of reduced atmospheric moisture and enhanced slightly upwind as moist air moved into a region of increased convection compared to control simulations (CTRL). Moreover, sensible (latent) heat flux and PBL heights were increased (decreased) compared to CTRL. In addition, the wet ensemble experiments reduced PBL heights and sensible heat flux and increased cloud cover over karst compared to CTRL. Other changes were noted in equivalent potential temperature (θe) and vertical motions and development of new mesoscale circulation cells with alterations in soil moisture over WKYPK. Finally, the location of simulated rainfall patterns were altered by both dry and wet ensembles with the greatest sensitivity to simulated rainfall occurring during weakly forced or nonfrontal cases. Simulated rainfall for the dry ensemble was more similar to the North American Regional Reanalysis (NARR) than CTRL for the nonfrontal case. Furthermore, the initial state of the atmosphere and convective triggers were found to either enhance or diminish simulated atmospheric responses.
Captopril suppression: limitations for confirmation of primary aldosteronism
Authors: Westerdahl Christina , Bergenfelz Anders , Isaksson Anders , Valdemarsson Stig 
Published: January 2011

Introduction: The aldosterone/renin ratio (ARR) is the first line screening test for primary aldosteronism (PA). However, in hypertensive patients with an increased ARR, PA needs to be confirmed by other means. Methods: A 25 mg oral captopril test was performed in 16 healthy subjects to obtain reference values for aldosterone and ARR at 120 minutes after the test. Subsequently these data were applied to 46 hypertensive patients screened for PA with an increased ARR. Results: At 120 minutes after the captopril test ARR decreased in healthy subjects within a narrow range, but remained high in patients with PA and in patients with primary hypertension, especially for those with low renin characteristics. At 120 minutes after captopril, the range of ARR in primary hypertensive patients overlapped in 88% of the cases with the range of the ARR in the PA patients. Sensitivity and specificity of basal ARR and ARR after the captopril test to diagnose PA, calculated as receiver operator characteristics, showed an area under the curve of 0.595 for basal ARR and 0.664 for ARR at 120 minutes after the test. Conclusion: The ARR at 120 minutes after the captopril test is only marginally better than basal ARR in diagnosing PA in hypertensive patients screened with an increased ARR. Owing to an overall limited capacity to clearly discriminate PA from primary hypertension, the test could not therefore be recommended for the confirmatory diagnosis of PA.
Qualitative study of high-cost patients in an urban primary care centre
Authors: Sledge William H , Wieland Melissa , Sells David , Walden David , Holmberg Christine , Zhenqiu Lin  , Davidson Larry 
Published: January 2011

Objectives: We examined patient accounts of illness and care among primary care patients whose medical services costs were high in order to illuminate factors associated with high cost. Methods: Thirty-three primary care patients with multiple chronic illnesses in an urban clinic serving a resource poor neighbourhood were selected from a range of high medical cost patients. Participants were interviewed with open-ended questions to investigate experiences of illnesses and care; their responses were examined for prominent themes using qualitative analysis methodology. Results: Patients sorted themselves into two categories based on the dominant focus of the roles of the care givers: one termed ‘professional’, in which the focus was on the competence and effectiveness of the care giver; and the second, ‘personal’, in which the focus was on the interpersonal relationship. Discussion: We examine similarities with other recent studies, suggest factors influencing these two different types of relationships such as intensity of involvement in the healthcare system as well as personality characteristics, and explore the challenge for healthcare programme development. We also noted that these two ways of conceptualizing the doctor—patient relationship may have adaptive or maladaptive consequences depending on the match between physician and patient.
KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation
Authors: Lee Youl-Nam , Brandal Stephanie , Noel Pierre , Wentzel Erik , Mendell Joshua T. , McDevitt Michael A. , Kapur Reuben , Carter Melody , Metcalfe Dean D. , Takemoto Clifford M. 
Published: January 2011

AbstractActivating mutations in codon D816 of the tyrosine kinase receptor, KIT, are found in the majority of patients with systemic mastocytosis. We found that the transcription factor, microphthalmia-associated transcription factor (MITF), is highly expressed in bone marrow biopsies from 9 of 10 patients with systemic mastocytosis and activating c-KIT mutations. In primary and transformed mast cells, we show that KIT signaling markedly up-regulates MITF protein. We demonstrate that MITF is required for the proliferative phenotype by inhibiting colony-forming units with sh-RNA knockdown of MITF. Furthermore, constitutively active KIT does not restore growth of primary MITF-deficient mast cells. MITF mRNA levels do not change significantly with KIT signaling, suggesting posttranscriptional regulation. An array screen from mast cells identified candidate miRNAs regulated by KIT signaling. We found that miR-539 and miR-381 are down-regulated by KIT signaling and they repressed MITF expression through conserved miRNA binding sites in the MITF 3′-untranslated region. Forced expression of these miRNAs suppressed MITF protein and inhibited colony-forming capacity of mastocytosis cell lines. This work demonstrates a novel regulatory pathway between 2 critical mast cell factors, KIT and MITF, mediated by miRNAs; dysregulation of this pathway may contribute to abnormal mast cell proliferation and malignant mast cell diseases.
Origin, functional role, and clinical impact of Fanconi anemia FANCA mutations
Authors: Castella Maria , Pujol Roser , Callén Elsa , Trujillo Juan P. , Casado José A. , Gille Hans , Lach Francis P. , Auerbach Arleen D. , Schindler Detlev , Benítez Javier , Porto Beatriz , Ferro Teresa , Muñoz Arturo , Sevilla Julián , Madero Luis , Cela Elena , Beléndez Cristina , de Heredia Cristina Díaz , Olivé Teresa , de Toledo José Sánchez , Badell Isabel , Torrent Montserrat , Estella Jesús , Dasí Ángeles , Rodríguez-Villa Antonia , Gómez Pedro , Barbot José , Tapia María , Molinés Antonio , Figuera Ángela , Bueren Juan A. , Surrallés Jordi 
Published: January 2011

Abstract
Fanconi anemia is characterized by congenital abnormalities, bone marrow failure, and cancer predisposition. To investigate the origin, functional role, and clinical impact of FANCA mutations, we determined a FANCA mutational spectrum with 130 pathogenic alleles. Some of these mutations were further characterized for their distribution in populations, mode of emergence, or functional consequences at cellular and clinical level. The world most frequent FANCA mutation is not the result of a mutational “hot-spot” but results from worldwide dissemination of an ancestral Indo-European mutation. We provide molecular evidence that total absence of FANCA in humans does not reduce embryonic viability, as the observed frequency of mutation carriers in the Gypsy population equals the expected by Hardy-Weinberg equilibrium. We also prove that long distance Alu-Alu recombination can cause Fanconi anemia by originating large interstitial deletions involving FANCA and 2 adjacent genes. Finally, we show that all missense mutations studied lead to an altered FANCA protein that is unable to relocate to the nucleus and activate the FA/BRCA pathway. This may explain the observed lack of correlation between type of FANCA mutation and cellular phenotype or clinical severity in terms of age of onset of hematologic disease or number of malformations.
Prevalence and risk factors of the metabolic syndrome in adult survivors of childhood leukemia
Authors: Oudin Claire , Simeoni Marie-Claude , Sirvent Nicolas , Contet Audrey , Begu-Le Coroller Audrey , Bordigoni Pierre , Curtillet Catherine , Poirée Maryline , Thuret Isabelle , Play Barbara , Massot Mara Carazza , Chastagner Pascal , Chambost Hervé , Auquier Pascal , Michel Gérard 
Published: January 2011

Abstract
We evaluate the prevalence and risk factors of the metabolic syndrome (MS) in young adults surviving childhood leukemia. During the years 2007 to 2008, assessment of MS was proposed to all adults included in the Leucémie de l'Enfant et de l'Adolescent program, a French prospective multicentric cohort of leukemia survivors. Among 220 eligible patients, 184 (83.6%) had complete evaluation. Median age at evaluation and follow-up duration were 21.2 and 15.4 years. Overall prevalence of MS was 9.2% (95% confidence interval, 5.5-14.4). There was no association of MS with sex, age at diagnosis, leukemia subtype, steroid therapy, and central nervous system irradiation. Patients were stratified according to 4 therapeutic modalities: chemotherapy alone (n = 97), chemotherapy and central nervous system irradiation (n = 27), hematopoietic stem cell transplantation (HSCT) without (n = 17) or with (n = 43) total body irradiation (TBI). MS occurred in 5.2%, 11.1%, 5.9%, and 18.6% of them, respectively. The higher risk observed in the HSCT-TBI group was significant in univariate and in multivariate analysis (odds ratio [OR] = 3.9, P = .03). HSCT with TBI was associated with a higher rate of hypertriglyceridemia (OR = 4.5, P = .004), low level of high-density lipoprotein cholesterol (OR = 2.5, P = .02), and elevated fasting glucose (OR = 6.1, P = .04) So, TBI is a major risk factor for MS. Further studies are warranted to explain this feature.
Research Resource: Comparative Nuclear Receptor Atlas: Basal and Activated Peritoneal B-1 and B-2 Cells
Authors: Diehl Cody J. , Barish Grant D. , Downes Michael , Chou Meng-Yun , Heinz Sven , Glass Christopher K. , Evans Ronald M. , Witztum Joseph L. 
Published: January 2011

AbstractNaïve murine B cells are typically divided into three subsets based on functional and phenotypic characteristics: innate-like B-1 and marginal zone B cells vs. adaptive B-2 cells, also known as follicular or conventional B cells. B-1 cells, the innate-immune-like component of the B cell lineage are the primary source of natural antibodies and have been shown to modulate autoimmune diseases, human B-cell leukemias, and inflammatory disorders such as atherosclerosis. On the other hand, B-2 cells are the principal mediators of the adaptive humoral immune response and represent an important pharmacological target for various conditions including rheumatoid arthritis, lupus erythematosus, and lymphomas. Using the resources of the Nuclear Receptor Signaling Atlas program, we used quantitative real-time PCR to assess the complement of the 49 murine nuclear receptor superfamily expressed in quiescent and toll-like receptor (TLR)-stimulated peritoneal B-1 and B-2 cells. We report the expression of 24 nuclear receptors in basal B-1 cells and 25 nuclear receptors in basal B-2 cells, with, in some cases, dramatic changes in response to TLR 4 or TLR 2/1 stimulation. Comparative nuclear receptor profiling between B-1 and peritoneal B-2 cells reveals a highly concordant expression pattern, albeit at quantitatively dissimilar levels. We also found that splenic B cells express 23 nuclear receptors. This catalog of nuclear receptor expression in B-1 and B-2 cells provides data to be used to better understand the specific roles of nuclear receptors in B cell function, chronic inflammation, and autoimmune disease.
Heteroassociation of Anions with Acidic Functionalities in Acetonitrile
Authors: Wada Taishi , Yamashita Masumi , Zheng Xin , Hou Xiaohong , Kobiro Kazuya 
Published: January 2011

Abstract
Simple aromatic acids showed successive 2:1 (acid:anion) and 1:1 heteroassociation with anions in polar CH3CN. The formation of 2:1 heteroassociate was rationalized from their sigmoidal titration profiles of acids by anions and ESI-MS measurement. Boronic acid and sulfonamide derivatives having different acidic functionalities also exhibited similar titration profiles.