bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of A Book On Cultivating Manners For Pancasila And Citizenship Education Subjects For Class IV Elementary School Students
Authors: Sa'adah Fatikhatus 
Published: April 2024

This study aimed to create a book that can assist kids in cultivating proper etiquette. The research employed the Research and Development (R&D) method, utilising the ADDIE model, which consisted of five stages: Analysis, Design, Development, Implementation, and Evaluation. The data was collected through interviews and questionnaires. In addition, the data was analysed using two distinct stages: the expert evaluation stage and the product trial stage. The study’s findings, derived from expert testing, demonstrated the feasibility of the courtesy book yielded percentation comprised 95% of media experts, 88% of material experts, and 92% of linguists. The user conducted trials with students and achieved outstanding results in the One to One Evaluation (96%), Small Group (94%), and Field Test (94%), respectively. These findings demonstrated that the book product designed to inculcate courteousness in fourth-grade primary school students is appropriate for implementation.
Implementasi Kemala-Smart untuk Meningkatkan Kualitas Layanan Posyandu
Authors: Indrasari Widyaningrum , Ariyanti Shallu Fidhah , Hersaputra Nugraha , Nuvus Afiva Riyatun , Dewanti Kunti , Zulmi Febrian , Ramdhan Muhammad Rofiid , Subekti Fajar , Bahagia Marthin Virgo , Muliyati Dewi , Firmansyah Heri 
Published: April 2024

Posyandu is one of the social institutions that plays a role in the community participation approach in the health sector. The quality and effectiveness of Posyandu depend on the role of Posyandu cadres. Posyandu cadres of Kemala Bhayangkari still use a manual approach in collecting data on toddler development. Using manual methods creates the potential for data errors, loss of information, and difficulties in accessing data. Through the Community Service Program of 2023, the smart sensing device has been developed using sensors system that is integrated with the Internet of Things (IoT). Furthermore, there is a Posyandu service website containing information about available services and data on the growth and development of toddlers. The success of implementing activities is assessed by participants through a questionnaire. The results achieved from this program show that the quality of the device, website and database system is very good (96%); the system is able to improve the quality of posyandu services, especially in the context of recording and reporting growth and development data at Posyandu Kemala Bhayangkari Ciracas (93%); and the need for posyandu cadres assistance and continuity of activities (93%).

Abstrak
Posyandu merupakan salah satu pranata sosial yang berperan dalam pendekatan partisipasi masyarakat di bidang kesehatan. Kualitas dan efektivitas Posyandu bergantung pada peran kader Posyandu. Kader Posyandu Kemala Bhayangkari masih menggunakan pendekatan manual dalam pendataan perkembangan balita. Penggunaan metode manual menimbulkan potensi kesalahan data, kehilangan informasi, dan kesulitan dalam mengakses data. Pada Program Pengabdian Kepada Masyarakat Terintegrasi Kuliah Kerja Nyata (PKM-KKN) tahun 2023, telah dikembangkan alat sensor cerdas menggunakan sistem sensor yang terintegrasi dengan Internet of Things (IoT). Selain itu, terdapat situs web layanan Posyandu berisi informasi seputar layanan yang tersedia dan data tumbuh kembang balita. Keberhasilan pelaksanaan kegiatan dinilai oleh peserta melalui kuisioner. Hasil yang dicapai dari program ini menunjukan bahwa kualitas alat, situs web, dan sistem database yang dikembangkan sangat baik (96 %); sistem yang dikembangkan mampu meningkatkan mutu layanan posyandu khususnya dalam rangka pencatatan dan pelaporan data tumbuh kembang di Posyandu Kemala Bhayangkari Ciracas (93 %); dan perlu adanya keberlanjutan kegiatan (93%).
Literasi Keuangan untuk Menumbuhkan Kecerdasan Finansial Mahasiswa
Authors: Kurnianti Destria , Khairunnisa Hera , Handarini Dwi , Marsofiyati  , Anwar Choirul , Dianta Karuniana , Yusuf Muhammad , Mundhiharno  , Yaacob Mohd Hasimi , Malzara Vidia Ratu Balqis , Sari Rini Nurmala , Haneul  , Safitri Gita 
Published: April 2024

This community service is aimed to teach students about the important role of financial literacy in shaping students' understanding of personal financial aspects. The participants of this activity is students of the Faculty of Economics, Universitas Negeri Jakarta. To teach financial literacy to students, the research team invited a lecturer speaker and a speaker from Finansialku as a digital financial application to give knowledge about about financial planning, investment, and debt management. The outcome of this event is the findings that provide insight into the effectiveness of financial literacy training and its potential impact on students' financial lives.

Abstrak
Pengabdian masyarakat ini bertujuan untuk mengajarkan kepada mahasiswa tentang peran penting literasi keuangan dalam membentuk pemahaman mahasiswa terhadap aspek keuangan pribadi. Peserta kegiatan ini adalah mahasiswa Fakultas Ekonomi Universitas Negeri Jakarta. Untuk mengajarkan literasi keuangan kepada mahasiswa, tim peneliti mengundang pembicara dosen dan pembicara dari Finansialku sebagai aplikasi keuangan digital untuk memberikan pengetahuan mengenai perencanaan keuangan, investasi, dan pengelolaan utang. Hasil dari kegiatan ini adalah temuan yang memberikan wawasan tentang efektivitas pelatihan literasi keuangan dan potensi dampaknya terhadap kehidupan keuangan mahasiswa.
HUBUNGAN KARAKTERISTIK PEKERJA DAN IKLIM KESELAMATAN KERJA DENGAN PERILAKU TIDAK AMAN PEKERJA OPERASIONAL PT. BINTAN RESORT CAKRAWALA
Authors: Dewi Ruri Sukmawati , Kusmawan David , Sari Rumita Ena 
Published: April 2024

Iklim keselamatan kerja dan karakteristik individu berupa umur, jenis kelamin, pendidikan, pengalaman pelatihan, masa kerja dan status perkawinan memiliki pengaruh terhadap perilaku tidak aman. Tujuan penelitian ini adalah untuk melihat gambaran iklim keselamatan kerja, perilaku tidak aman, serta hubungan antara karakteristik dan iklim keselamatan kerja terhadap perilaku tidak aman. Desain penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Penghitungan sampel menggunakan metode simple random sampling dengan jumlah 194 sampel. Kesimpulan dalam penelitian ini Mayoritas pekerja memiliki tingkat pendidikan tinggi namun sebagian besar belum pernah mengikuti pelatihan dengan status masa kerja diatas lima tahun. Terdapat hubungan antara tingkat pendidikan (PR 1,971, 95%CI 0,721-5,393), pelatihan (PR 2,618, 95%CI 1,185-5,784), masa kerja (PR 2,197, 95%CI 1,165-4,413), status perkawinan (PR 1,509, 95%CI 0,493-4,621) dengan perilaku tidak aman. Proporsi perilaku tidak aman sebesar 16% dan kondisi iklim keselamatan yang tidak baik dengan skor mean <2,70. Terdapat hubungan yang signifikan antara dimensi iklim keselamatan terhadap perilaku tidak aman.
Compilation of Apatite Fission-Track Data from the Northeast Atlantic Realm: A Jigsaw Puzzle with Missing Pieces
Authors: Jess Scott , Gröger Heike , Hendriks Bert , Peace Alexander , Schiffer Christian 
Published: April 2024

Abstract
The northeast (NE) Atlantic is one of the best-studied geological regions in the world, incorporating a wide array of geological phenomena including extensional tectonism, passive margin development, orogenesis, and breakup-related volcanism. Apatite fission-track (AFT) thermochronology has been an important tool in studying the onshore evolution of the NE Atlantic for several decades. Unfortunately, large regional-scale studies are rare, making it difficult to study geological processes across the whole region. In this work, a compilation of published AFT data is presented from across Fennoscandia, the British Isles, East Greenland, and Svalbard, with the goal of providing an accessible overview of the data and how this vast body of work has improved our understanding of the region’s evolution. Alongside a review of previous literature, interpolated maps of fission track age and mean track length (MTL) highlight regional trends in the data that may result from major first-order processes and areas of low sample density that should be targeted for future study. Additionally, in the absence of metadata required for thermal history modeling, apparent exhumation rate estimates are calculated from available elevation profiles and the timing of major exhumation events inferred from “boomerang plots” of fission track ages against MTL values. Across Fennoscandia, data suggests that the opening of the NE Atlantic and exhumation of the margin have clearly played a major role in the thermal history of the upper crust. The remaining areas of Britain, Ireland, East Greenland, and Svalbard all present more complex trends consistent with a combination of the NE Atlantic’s opening and the interplay between specific bedrock geology of sampling sites and localized geological processes. Areas of low sample density include southern Britain, NE Britain, southeast Greenland, southern Svalbard, and Eastern Fennoscandia, each of which provides the natural laboratory required to answer many unresolved questions.
A multicentric, randomised, controlled clinical trial to study the impact of bedside model-informed precision dosing of vancomycin in critically ill children – BENEFICIAL trial
Authors: De Cock Pieter Albert , Colman Roos , Amza Anca , De Paepe Peter , De Pla Hans , Vanlanduyt Lieselot , Linden Dimitri Van Der 
Published: April 2024

Abstract

Background
Vancomycin is a commonly prescribed antibiotic to treat serious Gram-positive infections in children. The efficacy of vancomycin is known to be directly related to the pharmacokinetic/pharmacodynamic (PK/PD) index of the area under the concentration-time curve (AUC) divided by the minimal inhibitory concentration (MIC) of the pathogen. In most countries, steady state plasma concentrations are used as a surrogate parameter for this target AUC/MIC, but this practice has some drawbacks. Hence, AUC-based dosing using model-informed precision dosing (MIPD) tools has been proposed for increasing target attainment rate and reducing vancomycin-related nephrotoxicity. Solid scientific evidence for these claimed benefits is lacking in children. This randomized controlled trial aims to investigate the large-scale utility of MIPD dosing of vancomycin in critically ill children.
Methods
Participants from 14 neonatal intensive care, pediatric intensive care and pediatric haemo-oncology ward units from 7 hospitals are randomly allocated to the intervention or standard-of-care comparator group. In the intervention group, a MIPD dosing calculator is used for AUC-based dosing, in combination with extra sampling for therapeutic drug monitoring in the first hours of treatment, as compared to standard-of-care. An AUC24h between 400 to 600 is targeted, assuming an MIC of 1 mg/L. Patients in the comparator group receive standard-of-care dosing and monitoring according to institutional guidelines. The primary endpoint is the proportion of patients reaching the target AUC24h/MIC of 400–600 between 24 and 48 hours after start of vancomycin treatment. Secondary endpoints are the proportion of patients with (worsening) acute kidney injury during vancomycin treatment, the proportion of patients reaching target AUC24h/MIC of 400–600 between 48 and 72 hours after start of vancomycin treatment, time to clinical cure, ward unit length-of-stay, hospital length-of-stay and 30 day all-cause mortality.
Discussion
This trial will clarify the propagated benefits and provide new insights into how to optimally monitoring vancomycin treatment in critically ill children.
Trial registration
Trial Registration: Eudract number:2019-004538-40, registered: 2020-09-08
Overexpression of EZH2 is associated with clinicopathological parameters and poor prognosis in gliomas
Authors: Peng Can , Chen Wei , Yang Jun , Wang Li , Lu Lixia , Ge Rong 
Published: April 2024

Abstract

Histone methyltransferase EZH2, primarily localized in the nucleus, mediates constitutive Polycomb repressive complex activity by trimethylating lysine 27 of histone H3 (H3K27me3), leading to gene silencing through canonical and noncanonical mechanisms, resulting in transcriptional repression or activation. Its involvement is crucial in cell growth, proliferation, differentiation, and apoptosis, with its effects linked to the regulation of various targets and signaling pathways. Overexpression of EZH2 alters gene expression and function, thereby facilitating cancer progression. Recent research has identified the potential prognostic role of EZH2 expression in glioma patients. This study assesses the clinicopathological significance and prognostic value of EZH2 expression in gliomas using available data. The mRNA levels of EZH2 in tumor tissues and normal tissues were assessed using timer2.0 and data from CGCA and TGCA. The prognostic significance of EZH2 mRNA expression was determined using Kaplan-Meier plotter. A total of 147 clinical samples from glioma patients underwent immunohistochemistry analysis to evaluate EZH2 protein expression. Cox proportional hazards regression model and Kaplan-Meier survival curves were employed to assess the relationship between EZH2 expression, clinicopathological parameters, and overall survival (OS). Across multiple tumor cohorts, EZH2 was found to be upregulated and amplified in tumor tissues. In high-grade glioma patients, EZH2 expression was significantly increased, and higher EZH2 expression correlated with poorer OS, disease-specific survival (DSS), and progression-free interval (PFI). Therefore, the level of EZH2 may serve as a prognostic biomarker for glioma patients.
Expression of TNF-α, VEGF-A and microvessel density in cerebral alveolar echinococcosis and their correlation with perilesional brain edema
Authors: Wumier Wuerken , Abulizi Alimasi , Wu Pengfei , Jinsihan Najiahai , Wang Yongxin , Duysenbi Serick , Wang Zengliang 
Published: April 2024

Abstract

Alveolar echinococcosis (AE) is an infrequent zoonosis caused by Echinococcus multilocularis with a high degree of disability and mortality. Metastatic cerebral alveolar echinococcosis (CAE) is very rare and the lesions could lead to severe perilesional brain edema (PLBE) and subsequent uncontrollable intracranial hypertension. In this study, we sought to determine the expression of edema-associated factors in CAE lesions and their associations with PLBE. We retrospectively evaluated the clinical data of 18 CAE patients who received craniotomy. Severity of PLBE was described by edema index (EI). Archived specimens were processed for immunohistochemistry to detect tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor A (VEGF-A) and microvessel density (MVD) in CAE lesions. Expression intensity of CAE lesions was quantified by integral optical density (IOD) or count and was compared to the control group. The results showed TNF-α and VEGF-A were significantly expressed in CAE lesions (p < 0.001), their levels were positively correlated with PLBE (TNF-α: r = 0.701, p = 0.001; VEGF-A: r = 0.803, p < 0.001). The MVD of CAE lesions had a similar expression with normal brain tissue, and it was positively correlated with PLBE and VEGF-A (PLBE: r = 0.849, p < 0.001; VEGF-A: r = 0.687, p = 0.002). In conclusion, we speculated the upregulation of TNF-α and VEGF-A induced the formation of PLBE. Besides, though there was no extra increase of MVD, it was still regulated by VEGF-A and provided a better anatomical basis for the formation of PLBE and further promoted it.
Wild Fire Classification using Learning Robust Visual Features
Authors: Fan Xianjing , Zhu Taoyuan , Zi Xing , Tao Xian , Prasad Mukesh 
Published: April 2024

Abstract

The diversity in the texture, color, and shape of flames, and their similarity to most sunset skies and red forests, has always made reducing false alarms in forest fire detection a challenging task. Traditional image processing methods rely too heavily on manual feature annotation. Using conventional machine learning models can effectively extract flame characteristics and reduce the error rate of manual annotation, but their limited local perception often leads to a high rate of false alarms. This paper proposes the use of the self-supervised model with Learning Robust Visual Features (DINOV2) for feature extraction, and a classification head for categorizing forest fires. In tests across most fire datasets, DINOV2 achieved an accuracy rate of up to 99% while simultaneously reducing the rate of false alarms.
Weighted pseudo almost automorphic mild solutions for two-term fractional order differential equations via measure theory
Authors: Boukli-Hacene Nadira , Djoubir Baya , Ezzinbi Khalil 
Published: April 2024

Abstract

In this article, we show sufficient conditions ensuring the existence and uniqueness of pseudo almost automorphic solution using measure theory to the two-term fractional order differential equation in the form\begin{equation*} D_{t}^{\alpha}u'(t)+\gamma D_{t}^{\beta}u(t)= Au(t)+D_{t}^{\alpha}f(t,u(t)), t\in\mathbb{R},0<\alpha \leqslant \beta < 1,\gamma \geqslant 0.\end{equation*}Where \(A\) is a sectorial operator of angle \(\beta \frac{\pi}{2}\) , the fractional derivative is understood in the Weyl sense and the forcing term \(f\) of the equation is \(\mu\) -Stepanov-like pseudo almost automorphic function, $\mu$ is a positive measure on \(\mathbb{R}\) . An example is given for illustration.
Kinematics and spatial structure analysis of TBM gunite robot based on D-H parameter method
Authors: Jia Lianhui , Liu Shenyao , Cao Chenxu , Kang Yehao , Zhu Ying , Wang Lijun , Cheng Ruixue , Xu Donglai 
Published: April 2024

Abstract

In modern tunnel construction, TBM (Tunnel Boring Machine) plays a very important role. In response to the needs of tunnel wall reinforcement and TBM automated construction for tunnel construction, a shotcrete mechanism mounted on the TBM is designed. In order to evaluate the kinematic performance of the mechanism, this paper studies the forward and inverse kinematics and spatial architecture of the TBM shotcrete robot. Firstly, based on the D-H parameter method, the number of joints and links is determined and structural analysis is performed to obtain the robot's forward kinematics equation, achieving the mapping between joint space and pose space. Then, by determining the joint variables, the mapping of the end tool in Cartesian space is achieved. Finally, based on the Monte Carlo random sampling method, the workspace of the robot is constructed, and its reachability and flexibility within the robot workspace are evaluated. The performance of the device is verified by building a prototype, which meets the requirements well. Through the research in this paper, it can provide theoretical basis and guidance for the design and control of the shotcrete robot.
Clinical Characteristics of HIV-Associated Tracheobronchial Talaromyces marneffei Infection in Seven Patients in Guangxi, China
Authors: Pan Mianluan , Wu Hongjie , Lin Hairong , Peng Zhimin , Huang Jie , Zhang Jianquan 
Published: April 2024

Abstract

Objectives: Tracheobronchial Talaromyces marneffei (TM) infections among HIV-infected patients are rare. To improve understanding, we analysed the clinical features, immune mechanisms, treatment, and prognosis.
Methods: We collected clinical information from patients with talaromycosis admitted to the Fourth People’s Hospital of Nanning from January 2015 to June 2022 and retrospectively analyzed their clinical characteristics and prognosis.
Results: HIV-positive patients (n = 1567) were enrolled. Of seven patients with tracheobronchial T. marneffei infection were all men with a median age of 48 years (range 39–50 years). Cough, sputum, fever, and weight loss were the most common symptoms. The total white blood cell count was normal or decreased, and all lymphocyte counts decreased. All patients had reduced CD4+ T-cell counts, below 50 cells/μL. Chest CT imaging signs included patchy signals or large areas of exudation. Endoscopically, the trachea and bronchial mucosa showed congestion, edema, surface attachment, nodules, lumen stenosis, obstruction, etc. T. marneffei spores were found on bronchial mucosal pathology in all 7 cases. Five patients were initially treated with intravenous infusion of amphotericin B for 2 weeks, followed by oral itraconazole capsules (200 mg) twice daily, and two patients were initially treated with itraconazole. Four patients were cured, 2 improved, and 1 died.
Conclusions: It is suggested that bronchoscopy should be performed in HIV-positive patients with pulmonary lesions to improve the diagnostic rate of tracheobronchial T. marneffei.
Development of an eco-friendly voltammetric approach for determination of anti-coagulant drug edoxaban by highly sensitive iron oxide prob
Authors: Rizk Mohamed. , Hendawy Hassan A. M. , Elkhalek Ola Abd , El-Alamin Maha Mahmoud Abou 
Published: April 2024

Abstract

Edoxaban tosylate monohydrate (EDTM) is a direct oral anticoagulant drug that has recently been incorporated into most COVID-19 treatment protocols as either prophylaxis or therapy because it is effective and safe in the treatment of coagulopathy that is life-threatening in post-COVID-19. So, we developed a new, eco-friendly, sensitive differential pulse voltammetric method using 10.0% iron oxide nanoparticles as a modified carbon paste electrode (10.0% Fe2O3/CPE) in 0.1M borate buffer pH 10.0 as a supporting electrolyte. The electrochemical behavior of EDTM confirmed irreversible diffusion-controlled oxidation. Our modified sensor (10.0% Fe2O3/CPE) showed high sensitivity with a linear relationship between the peak current and EDTM concentration over the concentration range of 200–3500 ng/mL with a correlation coefficient of 0.9995, a limit of detection of 60 ng/mL, and a limit of quantification of 100 ng/mL. Our suggested method was successfully applied in bulk, pharmaceutical dosage form, spiked human plasma, and urine with high recovery 100.81% ±1.48 The results were statistically compared with the reported method and found to be in good agreement with it.
Movie Review System Using Machine Learning
Authors: Mishra Rahul Mishra Rahul , Hemant Hemant , Bajaj Parveen Kumar Bajaj Parveen Kumar 
Published: April 2024

Abstract

Sentiment analysis, the natural language processing (NLP) industry, is concerned with discerning the emotional context of text. In the realm of movie reviews, sentiment analysis automates the task of determining whether a review conveys positive, negative, or neutral sentiment. This automation is beneficial for both moviegoers and industry stakeholders, as it provides valuable insights into audience reactions. Through the development of a basic sentiment analysis model using NLP techniques, we can effectively categorize movie reviews, offering valuable information to movie enthusiasts and aiding them in making informed decisions.
Hereditary thrombotic thrombocytopenic purpura mimicking idiopathic thrombocytopenic purpura was revealed by miscarriage——Novel Compound Heterozygous Mutations in hTTP
Authors: Zhou Ruiqing , Wang Jiahuan , Wang Shunqing , Li Yumiao , Xu Shilin , Mo Wenjian 
Published: April 2024

Abstract

We report a case of early-onset hereditary thrombotic thrombocytopenic purpura in a 16-years old girl, who suffered from solely thrombocytopenia and was misdiagnosed as idiopathic thrombocytopenic purpura for years until two failed gestations finally revealed the underlying cause. Novel compound heterozygous mutations c.2865G>A:p.Trp955X and c.721delG:p.Gly241fs in ADAMTS13 gene were found and were predicted to be associated with the disease. She responded to plasma therapy but renal dysfunction may remain longstanding.