bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transbronchial fine needle aspiration biopsy and rapid on‐site evaluation in the setting of superior vena cava syndrome
Authors: Brundyn K. , Koegelenberg C. F. N. , Diacon A. H. , Louw M. , Schubert P. , Bolliger C. T. , van den Heuvel M. M. , Wright C. A. 
Published: November 2011

AbstractThere is a paucity of prospective data on flexible bronchoscopy with rapid on‐site evaluation (ROSE) in the setting of superior vena cava (SVC) syndrome. The aims of this prospective study were to assess the diagnostic yield and safety of these investigations and specifically to evaluate the role of ROSE in limiting the need for tissue biopsies. Over a 5‐year period 48 patients (57.4 ± 9.7 years) with SVC syndrome secondary to intrathoracic tumors underwent flexible bronchoscopy with TBNA and ROSE. Endobronchial Forceps biopsy was reserved for visible endobronchial tumors with no on‐site confirmation of diagnostic material. ROSE confirmed diagnostic material in 41 cases (85.4%), and in only one of the remaining cases did the addition of a forceps biopsy increase the diagnostic yield (overall diagnostic yield of 87.5%). No serious complications were noted. The final diagnoses made included nonsmall lung cancer (n = 27), small cell lung cancer (n = 16), and metastatic carcinoma (n = 3). Two undiagnosed cases died of suspected advanced neoplasms (unknown primary tumors). We conclude that TBNA has a high diagnostic yield and is safe in the setting of SVC syndrome. With the addition of ROSE, tissue biopsy is required in the minority of cases. Diagn. Cytopathol. 2013;41:324–329. © 2011 Wiley Periodicals, Inc.
The cytologic diagnosis of gangliocytic paraganglioma: A case report
Authors: Dustin Simone M. , Atkins Kristin A. , Shami Vanessa M. , Adams Reid B. , Stelow Edward B. 
Published: November 2011

AbstractGangliocytic paragangliomas are rare tumors primarily found in the duodenum. We report a case of a woman who presented with a retroperitoneal lymph node involved by metastatic gangliocytic paraganglioma. Subsequently, fine‐needle aspiration (FNA) cytology was used to identify the primary duodenal gangliocytic paraganglioma. The smears of the aspirate material were highly cellular and contained a dominant population of epithelioid cells, a second population of ganglion cells and a third population of small, bland spindled cells. To our knowledge, the cytologic features of gangliocytic paraganglioma have not previously been documented. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
Signatures of natural selection among lineages and habitats inOncorhynchus mykiss
Authors: Limborg Morten T. , Blankenship Scott M. , Young Sewall F. , Utter Fred M. , Seeb Lisa W. , Hansen Mette H. H. , Seeb James E. 
Published: November 2011

AbstractRecent advances in molecular interrogation techniques now allow unprecedented genomic inference about the role of adaptive genetic divergence in wild populations. We used high‐throughput genotyping to screen a genome‐wide panel of 276 single nucleotide polymorphisms (SNPs) for the economically and culturally important salmonidOncorhynchus mykiss. Samples included 805 individuals from 11 anadromous and resident populations from the northwestern United States and British Columbia, and represented two major lineages including paired populations of each life history within single drainages of each lineage. Overall patterns of variation affirmed clear distinctions between lineages and in most instances, isolation by distance within them. Evidence for divergent selection at eight candidate loci included significant landscape correlations, particularly with temperature. High diversity of two nonsynonymous mutations within the peptide‐binding region of the major histocompatibility complex (MHC) class II (DAB) gene provided signatures of balancing selection. Weak signals for potential selection between sympatric resident and anadromous populations were revealed from genome scans and allele frequency comparisons. Our results suggest an important adaptive role for immune‐related functions and present a large genomic resource for future studies
The past as a determinant of the present: Historical continuity, collective angst, and opposition to immigration
Authors: Jetten Jolanda , Wohl Michael J. A. 
Published: November 2011

AbstractWe propose that the perceived continuity between a group's past and present can be a psychological resource that provides confidence in the group's future vitality, thereby reducing the need to preserve identity. In two studies, English participants were told that there was continuity or discontinuity between England's past and present. Both studies showed that higher identifiers (but not lower identifiers) experienced more collective angst (i.e., concern for the group's future) and were more opposed to immigration when English history was presented as discontinuous compared with continuous. Importantly, collective angst mediated the effect of the historical continuity manipulation on opposition to immigration. We conclude that, particularly among those higher in group identification, perceived discontinuity of the group's past can undermine the perceived vitality of the future, thereby increasing the need to preserve current collective identity. Copyright © 2011 John Wiley & Sons, Ltd.
Electropolymerization of Thin Film Conducting Polymer and Its Application for Simultaneous Determination of Ascorbic Acid, Dopamine and Uric Acid
Authors: Mazloum‐Ardakani M. , Sheikh‐Mohseni M. A. , Benvidi A. 
Published: November 2011

AbstractIn this paper electropolymerization of a thin film of para‐phenylenediamine (PPD) is studied at glassy carbon electrode (GCE) in sulfuric acid media by cyclic voltammetry. The results showed that this polymer was conducting and had a reproducible redox couple in the potential region from 0.0 to 0.4 V in phosphate buffer solution. This modified GCE (p‐PPD‐GCE) was applied for simultaneous determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) using differential pulse voltammetry (DPV). The p‐PPD‐GCE in 0.1 M phosphate buffer solution (pH 5.0) separated the DPV signals of AA, DA and UA with sufficient potential differences between AA–DA and DA–UA and also enhanced their oxidation peak currents. The oxidation currents were increased from 2.0 to 2000.0 µM for AA, 10.0 to 1250.0 µM for DA and 50.0 to 1600.0 µM for UA. The detection limits were evaluated as 0.4, 1.0 and 2.5 µM for AA, DA and UA, respectively (S/N=3).
Square Wave Voltammetry for Selective Detection of Dopamine Using Polyglycine Modified Carbon Ionic Liquid Electrode
Authors: Li Yonghong , Liu Xinsheng , Wei Wanzhi 
Published: November 2011

AbstractThe electrochemical polymerization of glycine on carbon ionic liquid electrode (CILE) was described. The presence of ionic liquid on the surface of CILE facilitated the electropolymerization of glycine. The polyglycine modified CILE provided a valid and simple approach to selectively detect dopamine in the presence of AA in physiological environment. The proposed sensor not only decreased the voltammetric responses of AA but also dramatically enhanced the oxidation peak current of DA compared to bare CILE. Using square wave voltammetry, the modified CILE showed good electrochemical behavior to DA, a linear range of 1.0×10−7–3.0×10−4 M in the presence of 1 mM ascorbic acid (AA) and a detection limit of 5.0×10−9 M was estimated (S/N=3).
Numerical analysis of a rapid magnetic microfluidic mixer
Authors: Wen Chih‐Yung , Liang Kuok‐Pong , Chen Hua , Fu Lung‐Ming 
Published: November 2011

AbstractThis paper presents a detailed numerical investigation of the novel active microfluidic mixer proposed by Wen et al. (Electrophoresis 2009, 30, 4179–4186). This mixer uses an electromagnet driven by DC or AC power to induce transient interactive flows between a water‐based ferrofluid and DI water. Experimental results clearly demonstrate the mixing mechanism. In the presence of the electromagnet's magnetic field, the magnetic nanoparticles create a body force vector that acts on the mixed fluid. Numerical simulations show that this magnetic body force causes the ferrofluid to expand significantly and uniformly toward miscible water. The magnetic force also produces many extremely fine finger structures along the direction of local magnetic field lines at the interface in both upstream and downstream regions of the microchannel when the external steady magnetic strength (DC power actuation) exceeds 30 Oe (critical magnetic Peclet number Pem,cr = 2870). This study is the first to analyze these pronounced finger patterns numerically, and the results are in good agreement with the experimental visualization of Wen et al. (Electrophoresis 2009, 30, 4179–4186).The large interfacial area that accompanies these fine finger structures and the dominant diffusion effects occurring around the circumferential regions of fingers significantly enhance the mixing performance. The mixing ratio can be as high as 95% within 2.0 s. at a distance of 3.0 mm from the mixing channel inlet when the applied peak magnetic field supplied by the DC power source exceeds 60 Oe. This study also presents a sample implementation of AC power actuation in a numerical simulation, an experimental benchmark, and a simulation of DC power actuation with the same peak magnetic strength. The simulated flow structures of the AC power actuation agree well with the experimental visualization, and are similar to those produced by DC power. The AC and DC power actuated flow fields exhibited no significant differences. This numerical study suggests approaches to maximize the performance of the proposed rapid magnetic microfluidic mixer, and confirms its exciting potential for use in lab‐on‐a‐chip systems.
Contactless dielectrophoretic spectroscopy: Examination of the dielectric properties of cells found in blood
Authors: Sano Michael B. , Henslee Erin A. , Schmelz Eva , Davalos Rafael V. 
Published: November 2011

AbstractThe use of non‐invasive methods to detect and enrich circulating tumor cells (CTCs) independent of their genotype is critical for early diagnostic and treatment purposes. The key to using CTCs as predictive clinical biomarkers is their separation and enrichment. This work presents the use of a contactless dielectrophoresis (cDEP) device to investigate the frequency response of cells and calculate their area‐specific membrane capacitance. This is the first demonstration of a cDEP device which is capable of operating between 10 and 100 kHz. Positive and negative dielectrophoretic responses were observed in red blood cells, macrophages, breast cancer, and leukemia cells. The area‐specific membrane capacitances of MDA‐MB231, THP‐1 and PC1 cells were determined to be 0.01518 ± 0.0013, 0.01719 ± 0.0020, 0.01275 ± 0.0018 (F/m2), respectively. By first establishing the dielectrophoretic responses of cancerous cells within this cDEP device, conditions to detect and enrich tumor cells from mixtures with non‐transformed cells can be determined providing further information to develop methods to isolate these rare cells.
Estimation and Prediction Tests of Cash Flow Forecast Accuracy
Authors: Yoo Choong‐Yuel , Pae Jinhan 
Published: November 2011

ABSTRACTRecently, analysts' cash flow forecasts have become widely available through financial information services. Cash flow information enables practitioners to better understand the real operating performance and financial stability of a company, particularly when earnings information is noisy and of low quality. However, research suggests that analysts' cash flow forecasts are less accurate and more dispersed than earnings forecasts. We thus investigate factors influencing cash flow forecast accuracy and build a practical model to distinguish more accurate from less accurate cash flow forecasters, using past cash flow forecast accuracy and analyst characteristics. We find significant power in our cash flow forecast accuracy prediction models. We also find that analysts develop cash flow‐specific forecasting expertise and knowhow, which are distinct from those that analysts acquire from forecasting earnings. In particular, cash flow‐specific information is more useful in identifying accurate cash flow forecasters than earnings‐specific information.Copyright © 2011 John Wiley & Sons, Ltd.
Effect of auditory input on activations in infant diverse cortical regions during audiovisual processing
Authors: Watanabe Hama , Homae Fumitaka , Nakano Tamami , Tsuzuki Daisuke , Enkhtur Lkhamsuren , Nemoto Kiyotaka , Dan Ippeita , Taga Gentaro 
Published: November 2011

AbstractA fundamental question with regard to perceptual development is how multisensory information is processed in the brain during the early stages of development. Although a growing body of evidence has shown the early emergence of modality‐specific functional differentiation of the cortical regions, the interplay between sensory inputs from different modalities in the developing brain is not well understood. To study the effects of auditory input during audio‐visual processing in 3‐month‐old infants, we evaluated the spatiotemporal cortical hemodynamic responses of 50 infants while they perceived visual objects with or without accompanying sounds. The responses were measured using 94‐channel near‐infrared spectroscopy over the occipital, temporal, and frontal cortices. The effects of sound manipulation were pervasive throughout the diverse cortical regions and were specific to each cortical region. Visual stimuli co‐occurring with sound induced the early‐onset activation of the early auditory region, followed by activation of the other regions. Removal of the sound stimulus resulted in focal deactivation in the auditory regions and reduced activation in the early visual region, the association region of the temporal and parietal cortices, and the anterior prefrontal regions, suggesting multisensory interplay. In contrast, equivalent activations were observed in the lateral occipital and lateral prefrontal regions, regardless of sound manipulation. Our findings indicate that auditory input did not generally enhance overall activation in relation to visual perception, but rather induced specific changes in each cortical region. The present study implies that 3‐month‐old infants may perceive audio‐visual multisensory inputs by using the global network of functionally differentiated cortical regions. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
Abnormal motor cortex excitability is associated with reduced cortical thickness in X monosomy
Authors: Lepage Jean‐François , Clouchoux Cédric , Lassonde Maryse , Evans Alan C. , Deal Cheri L. , Théoret Hugo 
Published: November 2011

AbstractTurner syndrome (TS) is a noninherited genetic disorder caused by the absence of one or part of one X chromosome. It is characterized by physical and cognitive phenotypes that include motor deficits that may be related to neuroanatomical abnormalities of sensorimotor pathways. Here, we used transcranial magnetic stimulation (TMS) and cortical thickness analysis to assess motor cortex excitability and cortical morphology in 17 individuals with TS (45, X) and 17 healthy controls. Exploratory analysis was performed to detect the effect of parental origin of the X chromosome (Xmat, Xpat) on both measures. Results showed that long‐interval intracortical inhibition was reduced and motor threshold (MT) was increased in TS relative to controls. Areas of reduced thickness were observed in the precentral gyrus of individuals with TS that correlated with MT. A significant difference between Xmat (n = 11) and Xpat (n = 6) individuals was found on the measure of long‐interval intracortical inhibition. These findings demonstrate the presence of converging anatomical and neurophysiological abnormalities of the motor system in X monosomy. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc.
The effect of rainstorm movement on urban drainage network runoff hydrographs
Authors: Seo Yongwon , Schmidt Arthur R. 
Published: November 2011

AbstractThis article explores the relations between network properties and the effect from moving rainstorms in terms of the peak response and time to centroid of hydrographs. A simple conceptual rectangular catchment is introduced with different configurations of drainage network simulated by the Gibbs stochastic model. The efficiency of the urban pipe networks varies widely compared with natural river networks; hence, the Gibbs model can be an appropriate approach to represent the network properties in urban drainage system. Simple cases of rainstorms moving with upstream and downstream directions and different speeds are considered to investigate the effect of rainstorm movement on urban drainage network runoff hydrographs. The results indicate that the effect of the direction and speed of the rainstorm movement varies significantly depending on the network properties. The relationship between storm speed and direction and the change in the peak runoff is dependent on the network configuration and network efficiency. In contrast to previous studies, this study indicates that the speed and direction of the rainfall movement that produces the maximum peak discharge changes depending on the network configuration. Copyright © 2011 John Wiley & Sons, Ltd.
Sensitization of ovarian carcinoma cells with zoledronate restores the cytotoxic capacity of Vγ9Vδ2 T cells impaired by the prostaglandin E2 immunosuppressive factor: Implications for immunotherapy
Authors: Lavoué Vincent , Cabillic Florian , Toutirais Olivier , Thedrez Aurélie , Dessarthe Benoît , de La Pintière Cécile Thomas , Daniel Pascale , Foucher Fabrice , Bauville Estelle , Henno Sébastien , Burtin Florence , Bansard Jean‐Yves , Levêque Jean , Catros Véronique , Bouet‐Toussaint Françoise 
Published: November 2011

AbstractEpithelial ovarian cancer (EOC) usually spreads into the peritoneal cavity, thereby providing an opportunity for intraperitoneal adoptive immunotherapy with Vγ9Vδ2 T lymphocytes, a T cell subpopulation endowed with high lytic properties against tumor cells. However, previous studies have reported that Vγ9Vδ2 T cells fail to expand from peripheral blood mononuclear cells in one‐third of patients with cancer. Here, from a cohort of 37 patients with EOC, a multiple correspondence analysis identified three populations, one of which was not suitable for Vγ9Vδ2 T‐cell adoptive therapy. Interestingly, the ineligible patients were identified based on the frequency of Vγ9Vδ2 T cells in their peripheral blood and the patients' age. The average time to tumor recurrence was also found to be significantly different between the three populations, suggesting that the innate immune response is involved in EOC prognosis. A dramatic decrease in the lytic properties of Vγ9Vδ2 T cells occurred following incubation with ascitic supernatant and was found to be associated with reduced perforin/granzyme degranulation. Prostaglandin E2, but not IL‐6, IL‐10, VEGF or TGF‐β, showed immunosuppressive effects in Vγ9Vδ2 T cells. Interestingly, our results emphasize that pretreating ovarian tumor cells with zoledronate partially reverses the immunosuppressive effects of ovarian cancer‐associated ascites and restores a high level of lytic activity. These data sustain that optimal Vγ9Vδ2 T‐cell adoptive immunotherapy previously requires counteracting the tumor immunosuppressive microenvironment. Altogether, our findings provide a rationale for clinically evaluating Vγ9Vδ2 T‐cell adoptive immunotherapy with intraperitoneal carcinomatosis presensitization by zoledronate in patients with EOC.
Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice
Authors: Yan Lin , DeMars Lana C. 
Published: November 2011

AbstractThe present study investigated the effects of dietary supplementation with methylseleninic acid (MSeA), in comparison with selenomethionine (SeMet), on spontaneous metastasis of Lewis lung carcinoma (LLC) in male C57BL/6 mice using intramuscular and subcutaneous injection models. Mice were fed AIN93G control diet or that diet supplemented with MSeA or SeMet at 2.5 mg selenium/kg for 4 weeks at which time they were injected intramuscularly or subcutaneously with 2.5 × 105 viable LLC cells. Experiments were terminated 2 weeks later for mice injected intramuscularly or 2 weeks after surgical removal of primary tumors from mice subcutaneously injected with cancer cells. Dietary supplementation with MSeA significantly reduced pulmonary metastatic yield when compared with the controls (p < 0.05) in both models; however, SeMet did not have such an effect. Supplementation with MSeA significantly decreased plasma concentrations of urokinase‐type plasminogen activator (p < 0.05) and plasminogen activator inhibitor‐1 (p < 0.05). Furthermore, MSeA significantly reduced plasma concentrations of vascular endothelial growth factor (p < 0.05), fibroblast growth factor basic (p < 0.05) and platelet‐derived growth factor‐BB (p < 0.05) when compared with the controls. Selenomethionine did not affect any of the aforementioned measurements. These results demonstrate that MSeA reduces spontaneous metastasis of LLC in mice, perhaps through inhibition of the urokinase plasminogen activator system and reducing angiogenesis.
Human leukocyte antigen G polymorphism is associated with an increased risk of invasive cancer of the uterine cervix
Authors: Ferguson Rhea , Ramanakumar Agnihotram V. , Koushik Anita , Coutlée François , Franco Eduardo , Roger Michel ,   the Biomarkers of Cervical Cancer Risk Study Team
Published: November 2011

AbstractHuman leukocyte antigen (HLA)‐G acts as negative regulator of the immune responses and its expression in tumor cells may enable them to escape immunosurveillance. The purpose of this study was to investigate the influence of HLA‐G polymorphism on risk of high‐grade cervical intraepithelial neoplasia (HG‐CIN) and cervical cancer in a Canadian population. The authors have analyzed 1,372 women from participants recruited between 2001 and 2009 in the ongoing Biomarkers of Cervical Cancer Risk case–control study. A total of 539 women with histologically confirmed HG‐CIN and invasive cancer formed the case series, and 833 women with normal cytology served as controls. Cervical specimens were tested for human papillomavirus (HPV) DNA using the MY09/11 PCR protocol and HLA‐G alleles where determined using a direct DNA sequencing procedures. HLA‐G polymorphisms were not associated with HG‐CIN or HPV infection. However, the risk for invasive cancer was significantly increased with the homozygous genotypes HLA‐G*01:01:02 [odds ratio (OR) = 3.52, 95% confidence interval (CI): 1.43–8.61, p = 0.006], −G*01:06 (OR = 19.1, 95% CI: 2.29–159, p = 0.005) and −G* 3′UTR 14‐bp insertion (OR = 2.17, 95% CI: 1.10–4.27, p = 0.020), whereas, the heterozygotic form of the G*01:01:01 wild‐type allele was significantly associated with a reduced risk of invasive cancer (OR = 0.31, 95% CI: 0.16–0.59, p < 0.0001) after adjusting for age, HPV infection and ethnicity. These associations were also observed with progression of disease from HG‐CIN to invasive cancer among HPV‐positive women. These results suggest that HLA‐G polymorphism is an independent risk factor for the development of invasive cervical cancer.