bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing sales mode selection and marketing effort for a B2C marketplace under green product investment uncertainty
Authors: Phan Dinh Anh , Vo Thi Le Hoa 
Published: February 2025

PurposeThis study investigates the circumstances under which a business to customer (B2C) marketplace chooses to implement green marketing to promote green product investment (GPI). It further identifies the optimal sales model approach for implementing green marketing under uncertainty about the effects of GPI.Design/methodology/approachWe examine an e-commerce (EC) supply chain involving a manufacturer who determines the product’s greenness level and a B2C marketplace who can operate in either an agency or a reselling mode and engages in green marketing to promote sales of green products. Using the backward induction method, we develop an analytical model to drive the optimal decisions and profits under each sales model.FindingsOur research demonstrates that high GPI uncertainty drives B2C marketplaces to adopt green marketing strategies. These initiatives not only prompt manufacturers to invest in eco-friendly products but also boost profits for all parties involved. Nevertheless, these benefits depend on the choice of a sales model between agency and reselling. Our findings offer a novel practical application into the relationship between GPI uncertainty and green marketing. When the GPI uncertainty is high, green marketing is profitable for the B2C marketplace regardless of which sales mode is adopted. However, when uncertainty is low, green marketing only benefits the B2C marketplace in the agency mode. Moreover, the interaction between GPI uncertainty and the referral fee exerts a moderating influence on the preferred sales mode for both the manufacturer and the B2C marketplace.Practical implicationsOur findings offer a novel practical application into the relationship between GPI uncertainty and green marketing. When the GPI uncertainty is high, green marketing is profitable for the B2C marketplace regardless of which sales mode is adopted. However, when uncertainty is low, green marketing only benefits the B2C marketplace in the agency mode. Moreover, the interaction between GPI uncertainty and the referral fee exerts a moderating influence on the preferred sales mode for both the manufacturer and the B2C marketplace.Originality/valueOverall, our research contributes to a deeper understanding of the complex but beneficial interplay between GPI uncertainty, green marketing and sales mode selection in an EC supply chain.
The prevalence and correlates of depression and anxiety symptoms in older adults receiving in‐home aged care: A cross‐sectional survey
Authors: Dickins Marissa , Kelly Julie , Paxton Susan , Kwan Baldwin , Carveth Deborah , Barker Anna , Smith Karen , Bhar Sunil , Davison Tanya E. 
Published: February 2025

AbstractObjectivesTo estimate the prevalence of depression and anxiety symptoms in older Australians accessing in‐home aged care, and to identify characteristics associated with symptoms.MethodsA cross‐sectional telephone survey with a random sample of in‐home aged care clients from a national provider (Silverchain) was conducted between November 2022 and July 2023. The percentage of clients experiencing depression and anxiety symptoms was estimated, weighted to the age and gender of the Silverchain population. Multivariable linear regression was utilised to identify characteristics associated with higher depression and anxiety symptoms.ResultsA total of 237 participants completed the survey. Over half (52%) of participants experienced symptoms of depression (≥5 on the PHQ‐9), while 16% experienced clinically meaningful symptoms indicative of probable major depressive disorder (≥10 on the PHQ‐9). Over one‐third (37%) of participants experienced symptoms of anxiety (≥5 on the GAD‐7), while 12% experienced clinically meaningful symptoms indicative of probable generalised anxiety disorder (≥10 on the GAD‐7). Most clients (61%) experienced symptoms of depression and/or anxiety, with 29% experiencing co‐morbid symptoms. Younger age, lower quality of life, higher loneliness, living in a major city (compared with rural/remote areas) and living with family (compared to living alone) were associated with higher levels of depression or anxiety symptoms in this cohort.ConclusionsSymptoms of depression and anxiety are common in older Australians accessing in‐home aged care, with many experiencing co‐morbid symptoms. In‐home aged care providers are ideally situated to identify and facilitate treatment and monitoring for these individuals.
Effect of women's self‐help group participation on their financial inclusion measured through a women‐centric index: A study in North‐East India
Authors: Roy Priyanka , Patro Binoti 
Published: February 2025

AbstractThis study attempts to examine the effect of women's participation in self‐help groups (SHGs) on their financial inclusion levels. A comprehensive financial inclusion index is created specifically suited to women by incorporating the concept of ‘autonomy’ in the usage of financial services. Adding this indicator with access and usage improves the practical effectiveness of women's financial inclusion as a means to a larger end. Further, objective weights have been assigned to the financial inclusion indicators through the application of the Criteria Importance through Inter‐criteria Correlation (CRITIC) method. The effect estimation is examined using propensity score matching (PSM) to gauge a true effect assessment free from self‐selection bias. The results are also checked for robustness using inverse probability weighted regression adjustment (IPWRA). Drawing primary data from 450 respondents from the Barak Valley region of Assam, the study establishes the importance of ‘autonomy’ in determining women's financial inclusion and finds SHG participation to be effective in enhancing the holistic financial inclusion of women. Underscoring the potential of SHGs in the upliftment of women, the study recommends regular monitoring of existing SHGs, besides expansion policies, to prevent group inactivity. To enhance women's financial autonomy, it is also suggested to conduct frequent training programmes on rights awareness, boosting self‐efficacy for financial management and self‐sufficiency in addressing financial challenges.
Scaffolding middle school mathematics curricula with large language models
Authors: Malik Rizwaan , Abdi Dorna , Wang Rose , Demszky Dorottya 
Published: February 2025

Despite well‐designed curriculum materials, teachers often face challenges implementing them due to diverse classroom needs. This paper investigates whether large language models (LLMs) can support middle school math teachers by helping create high‐quality curriculum scaffolds, which we define as the adaptations and supplements teachers employ to ensure all students can access and engage with the curriculum. Through cognitive task analysis with expert teachers, we identify a three‐stage process for curriculum scaffolding: observation, strategy formulation and implementation. We incorporate these insights into three LLM approaches to create warmup tasks that activate students' background knowledge. The best‐performing approach provides the model with the original curriculum materials and an expert‐informed prompt; this approach generates warmups that are rated significantly higher than those created by expert teachers in terms of alignment to learning objectives, accessibility to students working below grade level and teacher preference. This research demonstrates the potential of LLMs to support teachers in creating effective scaffolds and provides a methodology for developing artificial intelligence‐driven educational tools.
Practitioner notesWhat is already known about this topic

Scaffolding is essential for enabling students to access and engage with curriculum materials.
Large language models (LLMs) have shown promise in generating educational content and supporting teachers.
Teachers frequently need to adapt and supplement standardized curricula to meet the diverse needs of their students.
What this paper adds

Identifies a three‐stage curriculum scaffolding process (observation, strategy formulation, implementation) used by expert teachers.
Demonstrates that providing LLMs with additional context from the curriculum, such as the original warmup task, helps to ground the model and improve the quality of the generated warmup tasks.
Demonstrates that, when prompted well, LLMs can generate warmup tasks that are of similar or better quality compared to those created by expert teachers in terms of alignment to learning objectives, accessibility and teacher preference.
Implications for practice and/or policy

Provides practical suggestions for prompting LLMs to generate high‐quality warmup tasks for middle school math teachers, such as incorporating additional curriculum context and expert‐informed prompts.
Demonstrates how cognitive task analysis with expert teachers can be used to develop LLM‐based tools for educators that align with their practices and preferences.
Indicates that additional research is needed to explore the potential for LLMs to support other types of curriculum adaptations, evaluate their effectiveness in classroom settings and investigate how they can be effectively tailored to the specific needs and characteristics of individual students.
Sunscreen Formula of FeO(OH)·H2O/TiO2 With Spectral Selectivity to Enhance Collagen Biosynthesis via Fibroblast Test
Authors: Zhang Xun , Wen Ximing , Wang Yuling , Jiang Fangru , Chen Yiting , Liu Zhe 
Published: February 2025

ABSTRACTObjectiveTo develop a sunscreen formula with spectral selectivity that filters harmful light (280–550 nm) while allowing beneficial light (550–760 nm) to permeate and thus to boost collagen generation.MethodsA variety of sunscreen filters and their combinations were tested for transmittance spectrum. The spectral selectivity was quantified by Selection Index (SI), and the optimal formula was identified. Then, human dermal fibroblasts (HDFs) were subjected to simulated sunlight exposure with the application of this formula. The cell viability and collagen levels were measured post‐exposure.ResultsThe combination of TiO2 and FeO(OH)·H2O displays spectral selectivity and reaches the optimal SI value at the mixing ratio of 64:36. This mixture, when formulated with traditional UV filters, significantly elevates the level of Collagen I.ConclusionThis work uncovers the influence of spectral selectivity on the enhancement of sunscreen performance and proposes a filter combination with spectral selectivity. This formula, when integrated with conventional UV sunscreens, allows for the beneficial effects of sunlight to be more pronounced. This discovery may provide fresh insights for the design of future sunscreen products.
Weight loss and asthma control: A systematic review of randomized controlled trials
Authors: Farhangi Mahdieh Abbasalizad , Doumat George , Baroni Isis F. , Camargo Carlos A. 
Published: February 2025

SummaryBackgroundIn the current systematic review and meta‐analysis, we evaluated the possible role of weight loss on asthma control, quality of life (QOL), and clinical outcomes among patients with asthma.MethodsWe performed a systematic search of PubMed, CINAHL, and OVID Medline for randomized controlled human trials that examined the effects of weight loss on asthma control, QOL, and spirometry results, from 1 January 2000 to 31 December 2023. Twelve eligible studies (total n = 1052 participants) were included. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were used to evaluate the effect size. Subgroup analyses and meta‐regression approaches were performed to reveal possible sources of heterogeneity. Fractional polynomial modeling was performed to assess non‐linear associations.ResultsWeight loss reduced ACQ score (WMD −0.67 [95%CIs − 1.20, −0.13], P = 0.02; I2 91.3%, P < 0.001), and improved forced expiratory volume percent predicted (FEV)1pp (WMD 13.08 [95%CIs 2.42, 23.73], P = 0.02; I2 94.1%, P < 0.001) among patients with asthma. In a dose–response analysis, a significant non‐linear association was reported between change in weight and changes in FEV1pp (Pnon‐linearity = 0.01). The effects of weight loss on QOL (WMD 0.53 [−0.38, 1.44], P = 0.25; I2 95.6%, P < 0.001) and forced vital capacity percent predicted (FVC pp, WMD 4.90 [−3.22, 13.02], P = 0.24; I2 91.4%, P < 0.001) were not statistically significant.ConclusionWeight loss improves asthma control and FEV1pp among patients with asthma in a two‐class meta‐analysis. Because of the relatively low number of well‐designed clinical trials (n = 12), further trials are needed to better define the beneficial effects of weight loss on asthma control.
Astronomical Forcing of Palaeo‐Water Level Fluctuations of Western North China Craton During the Late Palaeozoic
Authors: Cao Yuge , Wang Jianqiang , Yang Wenjing , Nan Junxiang , Yu Shuhang 
Published: February 2025

ABSTRACTReconstruction of palaeo‐water level fluctuation has shown geoscientific significance for deciphering the hydrological evolution and sedimentary evolution in North China Craton (NCC) during the Late Palaeozoic. However, poorly constrained geochronology and understudied driving mechanisms have impeded a deeper comprehension of hydrological circulation. In this study, we established an astronomical time scale (ATS) of a Late Palaeozoic sequence of western NCC, spanning from ~275.842 ± 1.2 Ma to ~284.414 ± 1.2 Ma. We reconstructed the fluctuation of water level in the western NCC during the Late Palaeozoic by a sedimentary noise model. The ~2.4‐Myr eccentricity cycle was presented in both modelling resutls and Mn/Fe ratio through time series analysis. We speculated that the transition from in‐phase to anti‐phase between reconstructed water level variations and global sea level variations in ~2.4‐Myr rhythm indicated the changes in hydrological circulation, suggesting a shift from marine to terrestrial environment.
PLSCR1 suppresses SARS-CoV-2 infection by downregulating cell surface ACE2
Authors: Ma Ruiyi , Zhang Xinyi , Li Ruonan , Dong Xiaojing , Wang Wenjing , Jiang Qi , Xiao Xia , Shi Yujin , Chen Lan , Zheng Tian , Xiang Zichun , Ren Lili , Zhou Zhuo , Lei Xiaobo , Wang Jianwei 
Published: February 2025

ABSTRACT

Type I interferons exert their antiviral effects against SARS-CoV-2 by inducing the expression of interferon-stimulated genes (ISGs), including but not limited to LY6E, CH25H, IFITM2/3, and IFIH1. However, the antiviral effect and underlying mechanisms of action of most ISGs in SARS-CoV-2 infection are not yet fully understood. By screening 109 ISG-knockout cell lines, we identify that phospholipid scramblase 1 (PLSCR1), an interferon-inducible protein, acts as a crucial restriction factor against SARS-CoV-2 infection. Cells lacking PLSCR1 are highly susceptible to SARS-CoV-2 infection. Conversely, overexpression of PLSCR1 inhibits SARS-CoV-2 infection. Depletion of PLSCR1 enhances cellular entry of both pseudotyped and authentic SARS-CoV-2. Mechanistically, PLSCR1 inhibits SARS-CoV-2 entry by specifically downregulating plasma membrane expression of ACE2, the virus’s receptor, without affecting the overall levels of ACE2 within the cell. As such, we unraveled previously unappreciated mechanisms by which PLSCR1 exerts its restrictive effect on SARS-CoV-2. These data provide new insights into the interplay between host innate antiviral immunity and SARS-CoV-2 and shed light on novel antiviral therapeutics.

IMPORTANCE
Phospholipid scramblase 1 (PLSCR1) has been identified as a critical host restriction factor against SARS-CoV-2 infection. In this study, we demonstrated that PLSCR1 inhibited SARS-CoV-2 entry by downregulating the plasma membrane expression of ACE2, the primary receptor for viral entry. Our findings elucidate a novel host-pathogen interaction that not only deepens our understanding of the innate immune response to SARS-CoV-2 but offers potential strategies for therapeutic interventions against COVID-19.
Characterization of diet-linked amino acid pool influence on
Fusobacterium
spp. growth and metabolism
Authors: Robinson Avery V. , Vancuren Sarah J. , Marcone Massimo , Allen-Vercoe Emma 
Published: February 2025

ABSTRACT

The genus
Fusobacterium
contains multiple proteolytic opportunistic pathogens that have been increasingly linked to colorectal cancer (CRC). “Oncomicrobes” such as these fusobacterial species within the gut microbiota may contribute to CRC onset and/or progression. Protein-rich diets may both directly increase CRC risk and enrich for proteolytic oncomicrobes, including
Fusobacterium
spp. Individual food substrates vary in amino acid content, and released amino acid content that is not absorbed in the small intestine may influence the growth of colonic proteolytic fermenters. Fusobacteria such as
Fusobacterium
spp. are known to preferentially metabolize certain amino acids. As such, some foods may better support the growth of these species within the colonic environment than others. To explore this, in this study, we created free amino acid pools (FAAPs) to represent proportions of amino acids in major proteins of three common dietary protein sources (soy, beef, and bovine milk). Growth curves were generated for 39
Fusobacterium
spp. strains cultured in a dilute medium supplemented with each of the three FAAPs. Thereafter, amino acid use by 31 of the 39
Fusobacterium
spp. strains in each FAAP treatment was assessed. FAAP supplementation increased growth metrics of all
Fusobacterium
spp. strains tested; however, the strains varied greatly in terms of the FAAP(s) generating the greatest increase in growth. Furthermore, the amino acid utilization strategy was highly variable between strains of
Fusobacterium
spp. Neither growth metrics nor amino acid utilization could be explained by species classification of
Fusobacterium
spp. strains. This report expands upon the previous knowledge of fusobacterial amino acid metabolism and indicates that proteolytic oncomicrobial activity should be assessed in the context of available protein sources.

IMPORTANCE

Fusobacterium
spp. including
F. animalis
,
F. nucleatum
,
F. vincentii
, and
F. polymorphum
are common oral commensals with emerging importance in diseases across multiple body sites, including CRC. CRC lesions associated with fusobacteria tend to result in poorer prognosis and increased disease recurrence. While
Fusobacterium
spp. are thought to colonize after tumorigenesis, little is known about the factors that facilitate this colonization. Protein-rich diets yielding readily metabolized free amino acids within the colon may promote the growth of proteolytic fermenters such as fusobacteria. Here, we show that variable concentrations of free amino acids within pools that represent different dietary protein sources differentially influence fusobacterial growth, including CRC-relevant strains of
Fusobacterium
spp. This work highlights the high degree of variation in fusobacterial amino acid utilization patterns and suggests differing proportions of dietary amino acids that reach the colon could influence fusobacterial growth.
1`Antimicrobial and antivirulence function of cinnamaldehyde against
Streptococcus suis
type 2
Authors: Zhu Lexin , He Zhishu , Li Mengqing , Xu Jixin , Ding Wei , Zeng Wenzhen , Jiang Xiaowu 
Published: February 2025

ABSTRACT

Streptococcus suis
type 2 (SS2) is an important zoonotic pathogen for swine and humans. The increasing prevalence of antimicrobial resistance in
S. suis
isolates poses a threat to public health. This study investigated the antimicrobial activity and therapeutic potential of cinnamaldehyde (CA), a natural compound from cinnamon, against SS2. CA showed significant antimicrobial activity with a minimal inhibition concentration of 0.25 µg/mL and prolonged post-antibiotic effect of over 7 h in SS2. Increased bacterial cell membrane permeability and blocked protein synthesis of SS2 were observed after being treated with CA. CA could effectively prevent biofilm formation. CA treatment reduced the crucial virulence factor of suilysin expression and secretion in SS2 cells through a probable interaction with the suilysin protein. CA treatment could prominently alleviate both epithelial HEp-2 and phagocytic RAW264.7 cell cytotoxicity induced by SS2. The pathogenic SS2 strain was attenuated by CA, as demonstrated by the diminished adherence in HEp-2 cells, increased clearance by RAW264.7 and mice whole blood, and improved survival rate in a mouse infection model. CA possessed therapeutic efficacy since the CA treatment exhibited a 50% improvement in mouse survival rate, which surpassed the traditional ampicillin therapy control group. Alleviated clinical symptoms and histopathological phenotypes, with reduced bacterial burden in mouse organs after CA treatment, were examined. Overall, this study identified cinnamaldehyde as a novel antibacterial compound against SS2 with potential therapeutic protective effects, offering an alternative drug for controlling SS2 prevalence and infection.

IMPORTANCE

Widespread infections caused by
Streptococcus suis
type 2 (SS2) have garnered significant attention in the realm of public health due to their zoonotic nature. In recent years, antimicrobial resistance phenotypes in SS2 have emerged and intensified within the context of animal husbandry. Herbal compounds and medicinal plants are increasingly recognized as promising therapeutic alternatives for mitigating or addressing the challenges posed by antimicrobial resistance. The aim of this present study was to explore a novel compound of cinnamaldehyde, which obtained significant antimicrobial activity and potential therapeutic protective effect against SS2 infection. The research has made an innovative discovery that the bactericidal effect of cinnamaldehyde is associated with its antivirulence strategies, such as targeting the key virulence factors of SS2 and countering the bacterial infection process.
How do hospitals that serve low socioeconomic status patients achieve low readmission rates? A qualitative study of safety-net hospitals
Authors: Minges Karl E , Chen Peggy , Loh Kendall , Sutton La'Mont , Bernheim Susannah M 
Published: February 2025

BackgroundHospital readmissions are an important quality of care indicator and are tied to hospitals’ financial reimbursements. Safety-net hospitals, which serve a high proportion of patients of low socioeconomic status (SES), face unique challenges to reduce or maintain low readmission rates.ObjectiveWe sought to understand strategies high-performing safety-net hospitals used to achieve low 30-day risk-standardised readmission rates (RSRRs) using qualitative methodology.MethodsSafety-net hospital status was defined by public ownership or a Medicaid population that is greater than 1 SD higher than the state proportion of Medicaid patients and the hospital payer source is composed of at least 15% Medicaid patients. Safety-net hospitals were selected based on their ranking among the lowest 20% of heart failure RSRRs, the best-performing quintile. We purposefully sampled hospitals to ensure variation in characteristics and conducted on-site interviews with key hospital staff. A multidisciplinary team analysed the data using thematic analysis.ResultsWe performed site visits at 9 safety-net hospitals (RSRR range: 18.1%–21.6%) in 9 states and conducted in-depth interviews with 108 hospital staff. Several thematic attributes and organisational strategies were evident in high-performing safety-net hospitals: (1) strong hospital support for quality improvement at all levels; (2) tailoring resources to meet patient needs; (3) facilitating collaboration and communication among and between providers and patients; (4) creating strong relationships with postacute care facilities and communities and (5) proactive approach to healthcare policy changes and other external factors.ConclusionsThe provision of high-quality and equitable care in hospitals serving a high proportion of low-SES populations is influenced by several modifiable factors. These findings may serve to inform lower-performing safety-net hospitals on how to optimise patient care and improve readmission outcomes.