bluuebunny/crossref_metadata_2025_split huggingface dataset:
James Joyce. Chronisch rezidivierende Iritis infolge einer postvenerischen reaktiven Arthritis
Authors: Zeidler H. 
Published: February 2025

Zusammenfassung
Der irische Autor James Joyce (1882–1941) erkrankte an chronisch rezidivierender Iritis mit vielfältigen Komplikationen, die zu einer fast völligen Blindheit führten. Als Auslöser diskutiert wurden v. a. Syphilis und eine rheumatische Erkrankung im Sinne eines Reiter-Syndroms. Das zeitliche Zusammentreffen von venerischer Infektion, Arthritis und charakteristischen, ärztlich dokumentierten Merkmalen der Iritis einschließlich der typischen Komplikationen sind zusammen mit dem chronisch rezidivierenden Verlauf der Augenerkrankung überzeugende Argumente für eine postvenerische reaktive Arthritis. Für den ungünstigen Verlauf der Iritis sind möglicherweise eine familiäre Disposition und Rauchen mit verantwortlich. Es fehlen sichere Hinweise auf eine Syphilis, und v. a. die mehrfachen Rezidive der Iritis sind nicht vereinbar mit einer luetischen Infektion. Kunsthistoriker haben auch nach den medizinischen Publikationen, in denen die rheumatische Genese überzeugend diskutiert wurde, und in deren Kenntnis an der Diagnose der Syphilis festgehalten. Deshalb ist zu wünschen, dass zukünftig die kunsthistorische Literatur die Krankheit von Joyce entsprechend der medizinischen Erkenntnisse wiedergibt.
Motor and nonmotor features of p.A53T alpha-synuclein PD vs idiopathic PD: longitudinal data from the PPMI study
Authors: Simitsi Athina Maria , Sfikas Evangelos , Koros Christos , Papagiannakis Nikolaos , Beratis Ion , Papadimitriou Dimitra , Antonellou Roubina , Fragiadaki Styliani , Kontaxopoulou Dionysia , Picillo Marina , Pachi Ioanna , Alefanti Ioanna , Stamelou Maria , Barone Paolo , Stefanis Leonidas 
Published: February 2025

Abstract

Background and objectives
The phenotype of p.A53T-α-synuclein (SNCA) mutation carriers with Parkinson’s disease (A53T-PD) appears more severe compared to idiopathic PD (iPD), however, information is limited. Here we conducted a comprehensive longitudinal study to investigate the progression of motor and nonmotor features of Α53Τ-PD compared to iPD.

Methods
Detailed longitudinal 3-year data, concerning both motor and non-motor features, of 16 p.A53T-PD and 48 iPD, matched for age (51–53 years) and disease duration (approximately 4 years) at baseline, were downloaded from the Parkinson's Progression Markers Initiative (PPMI) database and compared between the two groups. Additionally, a cognitive composite score was generated by five cognitive tests, focused more on executive/visuospatial function.

Results
At baseline, global cognitive function, as assessed by the Montreal Cognitive Assessment (MOCA), was not significantly different between the two groups, in contrast to tests evaluating executive/visuospatial function, including the composite score, which were worse in A53T-PD. There was a significant decline over time in all neuropsychological tests in A53T-PD, while iPD remained stable. A similar pattern was revealed for motor status and function, as well as autonomic function, which were similar between the two groups at baseline, but deteriorated significantly only in A53T-PD over time.

Discussion
A53T-PD patients present an accelerated decline in both motor and non-motor parameters, with an impairment in executive-visuospatial function occurring early in the disease process. Such data may set the stage for targeted disease-modifying therapies in this particular subtype, while generated data may be widely applicable to iPD, which is largely a sporadic synucleinopathy.
Assessment of the influence of 660 and 808-nm PBM treatments on mitochondrial oxygen consumption of MG-63 osteoblast: a 3D cell culture study
Authors: Sleep Simone , Hryciw Deanne , Gunter Jennifer , Arany Praveen , Tomy Nifty , George Roy 
Published: February 2025

Abstract
This study explores the dose-dependent effects of 660-nm and 808-nm photobiomodulation (PBM) on mitochondrial oxygen respiration rate activity in MG-63 osteoblast cells using an innovative 3D in vitro spheroid model. MG-63 osteoblast cells were grown to 80% confluence and seeded in fish gelatin hydrogel (LunaGel™) to form 3D spheroids within 3–7 days. Spheroids were seeded on Seahorse microplates and incubated in a LunacrossLinker™ (visible light crosslinking system) for 2 min to give hydrogel a mid-stiffness of 3.5 kPa. Cells were exposed to PBM either 660-nm or 808-nm at panel setting of 5 J/cm2 and 15 J/cm2 and then assessed immediate (15 min before analysing) and 24 h time points. Mitochondrial activity was determined using an XFe96 Seahorse analyzer. Data distribution was assessed, and parametric or non-parametric tests and compared the mitochondrial respiratory capacity across different experimental conditions. The study indicated that 660-nm and 808-nm PBM could modulate mitochondrial functions in osteoblasts. The maximal respiratory rate for the fluency assessed at 808-nm wavelength was increased when cells were assessed immediate post. Interestingly, the 660-nm PBM-treated cells showed a decrease in oxygen consumption rate (OCR) at the basal and maximal bioenergetic state at all time points (immediate and 24 h.) and fluency compared to the untreated control. The effects of 660-nm and 808-nm wavelengths on osteoblast mitochondrial function suggest that PBM demonstrates differential modulation of osteoblast metabolism and bioenergetics depending on the wavelength. These findings have practical implications in both research and clinical settings, offering insights into selecting specific wavelengths for therapeutic applications.
Prospective observational study on the relationships between genetic alterations and survival in Japanese patients with metastatic castration-sensitive prostate cancer: the impact of IDC-P
Authors: Kato Masashi , Sato Hiroyuki , Naito Yushi , Yamamoto Akiyuki , Kawanishi Hideji , Nakano Yojiro , Nishikimi Toshinori , Kobayashi Masataka , Kondo Atsuya , Hirabayashi Hiroki , Katsuno Satoshi , Sakamoto Fumitoshi , Kimura Tohru , Yamamoto Shigeki , Araki Hidemori , Tochigi Kosuke , Ito Fumihiro , Hatsuse Hatsuro , Sassa Naoto , Hirakawa Akihiro , Akamatsu Shusuke , Tsuzuki Toyonori 
Published: February 2025

Abstract

Background
Intraductal Carcinoma of the Prostate (IDC-P) is a significant prognostic indicator for prostate cancer, which demonstrates significant associations with homologous recombination repair gene mutations (HRRm) and alterations in tumor suppressor genes. However, no study in Japan has investigated the association between IDC-P and genetic mutations in men with metastatic castration-sensitive prostate cancer (mCSPC).

Methods
This prospective observational study enrolled 102 de novo mCSPC (LATITUDE high-risk) patients diagnosed between 2018 and 2021, with subsequent monitoring of survival outcomes. A single genitourinary pathologist evaluated all needle biopsy slides. Genetic analyses were performed using the Myriad myChoice HRD plus™. These genetic analyses covered 108 genetic loci, including 15 HRRm genes, with a success rate of 91%.

Results
Genetic alterations were observed in 79 patients (77.5%), with 20 exhibiting HRRm (19.6%). Common genetic alterations included FOXA1 (29.4%) and TP53 (17.6%) mutations; BRCA (9.8%) mutations were the most frequent HRRm (BRCA1:2 cases, BRCA2:8 cases, including 6 biallelic). IDC-P-positive patients demonstrated a significantly higher frequency of genetic aberrations (82.6% vs. 50%, p = 0.0082). Patients with biallelic BRCA2, TP53, and PTEN mutations exhibited significantly poorer cancer-specific survival. Multivariate analysis identified lactate dehydrogenase (LDH) (HR 1.005, p = 0.035), TP53 mutations (HR 5.196, p < 0.001), biallelic BRCA2 mutations (HR 10.686, p = 0.005), and IDC-P as independent predictors of poor cancer-specific survival. No cancer-related deaths occurred in IDC-P-negative cases.

Conclusion
Our study emphasizes the significant association between IDC-P and an elevated incidence of genetic alterations in Japanese mCSPC patients, emphasizing the need for early genetic testing to guide therapeutic decision-making.
Classification of fundus autofluorescence images based on macular function in retinitis pigmentosa using convolutional neural networks
Authors: Kominami Taro , Ueno Shinji , Ota Junya , Inooka Taiga , Oda Masahiro , Mori Kensaku , Nishiguchi Koji M 
Published: February 2025

Abstract

Purpose
To determine whether convolutional neural networks (CNN) can classify the severity of central vision loss using fundus autofluorescence (FAF) images and color fundus images of retinitis pigmentosa (RP), and to evaluate the utility of those images for severity classification.

Study design
Retrospective observational study.

Methods
Medical charts of patients with RP who visited Nagoya University Hospital were reviewed. Eyes with atypical RP or previous surgery were excluded. The mild group was comprised of patients with a mean deviation value of > − 10 decibels, and the severe group of < − 20 decibels, in the Humphrey field analyzer 10-2 program. CNN models were created by transfer learning of VGG16 pretrained with ImageNet to classify patients as either mild or severe, using FAF images or color fundus images.

Results
Overall, 165 patients were included in this study; 80 patients were classified into the severe and 85 into the mild group. The test data comprised 40 patients in each group, and the images of the remaining patients were used as training data, with data augmentation by rotation and flipping. The highest accuracies of the CNN models when using color fundus and FAF images were 63.75% and 87.50%, respectively.

Conclusion
Using FAF images may enable the accurate assessment of central vision function in RP. FAF images may include more parameters than color fundus images that can evaluate central visual function.
Amphibian conservation in Europe: the importance of pond condition
Authors: López-de Sancha A. , Boix D. , Benejam L. , Briggs L. , Davidson T. A. , Fahy J. C. , Frutos-Aragón V. , Greaves H. M. , Lemmens P. , Mehner T. , Martín L. , Oertli B. , Sayer C. , Brucet S. 
Published: February 2025

Abstract
Most amphibians found in Europe inhabit ponds, small aquatic ecosystems commonly threatened by habitat degradation and destruction. Despite this situation, ponds are rarely considered in conservation policies. Thus, their effective management may present a significant opportunity to alleviate the ongoing decline of amphibian populations. In this study, we assessed if the favourable condition of a pond and its conservation status promotes its amphibian species richness, which was determined by using environmental DNA metabarcoding. For this, we investigated the condition of 154 ponds across six European countries, considered through measurements of their conservation status (Shallow Lentic Ecosystem Conservation Status index, ECELS), water quality and trophic state, and physical characteristics. By utilising Generalised Linear Mixed Models, we determined that a higher amphibian species richness, and a higher number of protected ones, are found in shallow ponds with a better pond condition, meaning a higher conservation status and a better water quality. Specifically, we observed that non-eutrophic ponds characterized by permeable and shallow basins with smooth slopes, and without weirs, foster a higher amphibian diversity. Conservation efforts targeting the preservation of natural pond hydrological processes and mitigating nutrient pollution are critical for safeguarding amphibian biodiversity in Europe and contributing to broader freshwater conservation goals.
Risk factors for interval breast cancer: insights from a decade of a mammography screening program
Authors: Subelack Jonas , Morant Rudolf , Blum Marcel , Eichenberger Alena , Geissler Alexander , Ehlig David 
Published: February 2025

Abstract

Purpose
Breast cancer remains a major global health issue, with mammography screening programs (MSPs) being critical for early detection to improve survival. Interval breast cancers (IBC) are an important quality criterion and have been linked with increased mortality. We aimed to identify risk factors for IBC diagnoses, based on MSP data.

Methods
In this retrospective cohort study, we merged data from the Swiss MSP “donna” with data from cancer registries from 2010 to 2019 to categorize cases as IBC or screen-detected breast cancer (SBC). We compared the incidence, tumor characteristics, and survival proportions of women with IBC versus SBC. We used a multivariable Poisson regression with robust errors to identify risk factors for IBC diagnoses.

Results
We identified 1134 breast cancer cases, specifically 251 IBC and 883 SBC. The 7-year survival proportions significantly deviated with 92.9% for women with IBC and 96.4% for women with SBC (p < 0.05). Women with IBC are diagnosed with significantly higher tumor stages (p < 0.05) and have a worse tumor biology in multiple dimensions e.g. larger tumor size or more often triple negative (p < 0.05). Higher breast density (BI-RADS d risk ratio (RR): 3.293), certain age groups (55–59 years RR: 1.345), and a family breast cancer history (RR: 1.299) were identified as significant (p < 0.05) risk factors for IBC diagnoses.

Conclusions
Women with IBC had lower overall survival proportions than women with SBC, possibly due to higher stages at diagnosis. Increased breast density and a positive family history of breast cancer could encourage MSPs to personalize their screening process (e.g. additional diagnostics).
Cultivating CSR: The Artistic Influence of Top Executives on Corporate Responsibility
Authors: Xiao Jinli , Liang Weijuan , Pan Yue , Tian Gary Gang 
Published: February 2025

Abstract
This study examines the impact of top executives’ art exposure on corporate social responsibility (CSR) through the lens of altruistic motivations. Utilizing data on artistic elements from China’s national intangible cultural heritage (ICH), we find a significant positive relationship between board chairs’ art exposure and CSR performance, particularly when the arts are influential and popular. The effect is more pronounced among female, older, and local board chairs, and in firms with a CSR committee, greater board− CEO cultural proximity, lower corporate risk, and those in culturally vibrant regions. Mechanism analyses reveal that art exposure increases board chairs’ likelihood of engaging with the arts and reduces socially irresponsible behaviors. However, CSR performance in firms led by board chairs with extensive art exposure is negatively associated with firm value. These findings suggest that board chairs with rich art exposure engage in CSR primarily driven by altruistic motives rather than self-interest. Overall, the study underscores the role of artistic engagement in promoting altruism and enhancing CSR, advocating for the integration of the arts into business strategies.
Estimating the impacts of climate change: reconciling disconnects between physical climate and statistical models
Authors: Polonik Pascal , Ricke Katharine , Burney Jennifer 
Published: February 2025

Abstract
Climate impacts studies often rely on empirical statistical methods to isolate the effects of changing environmental factors on human outcomes of interest. However, this research may not always account for the ways in which the underlying structure of climate might influence estimates from such models. Here we show how the different characteristic spatial scales of temperature (T) and precipitation (P), as well as the physical relationship between T and P, lead to biased historical and projected impact estimates in standard statistical approaches. Furthermore, we demonstrate how contemporary statistical research designs that exploit local fluctuations may unintentionally mis-characterize the influence of shifts in mean climate on outcomes of interest. Drawing on data from published studies we demonstrate these three issues; we focus primarily on the economic growth literature, though our results also apply to other contexts. We also propose several avenues to correct and bound the magnitude of the identified biases.
Memetic semantic boosting for symbolic regression
Authors: Leite Alessandro , Schoenauer Marc 
Published: February 2025

Abstract
This paper introduces a novel approach called semantic boosting regression (SBR), leveraging the principles of boosting algorithms in symbolic regression using a Memetic Semantic GP for Symbolic Regression (MSGP) algorithm as weak learners. Memetic computation facilitates the integration of domain knowledge into a population-based approach, and semantic-based algorithms enhance local improvements to achieve targeted outputs. The fusion of memetic and semantic approaches allows us to augment the exploration and exploitation capabilities inherent in Genetic Programming (GP) and identify concise symbolic expressions that maintain interpretability without compromising the expressive power of symbolic regression. Our approach echoes the boosting algorithm’s characteristic, where weak learners (e.g., MSGP) are sequentially improved upon, focusing on correcting previous errors and continuously enhancing overall performance. This iterative strategy, intrinsic to boosting methods, is adeptly adapted to our SBR model. Experimental results demonstrate that our memetic-semantic approach has equal or better performance when compared to state-of-the-art evolutionary-based techniques when addressing real-world symbolic regression challenges. This advancement helps tackle the bloating issue in GP and significantly improves generalization capabilities. However, akin to classic boosting algorithms, one limitation of our approach is the increased computational cost due to the sequential training of boosting learners.
Non-static axisymmetric structures embedded in an asymptotically $$\Lambda $$CDM universe
Authors: García-Reyes Gonzalo 
Published: February 2025

Abstract
We construct non-static adiabatic axisymmetric structures embedded in an asymptotically

$$\Lambda $$

Λ

CDM universe from given solutions of the Poisson’s equation of Newtonian gravity, using a particular form of the metric in isotropic coordinates. The approach is used in building of a razor-thin disk source made of perfect fluid for the McVittie metric, a system composite by a Plummer-type perfect fluid razor-thin disk surrounded by an halo also of perfect fluid, and a model of Miyamoto–Nagai-type anisotropic fluid thick disks, embedded in an asymptotic

$$\Lambda $$

Λ

CDM universe. In the especial case of spherical symmetry, we also present a family of models of expanding anisotropic thick spherical shells. Moreover, the geodesic motion of test particles in stable circular orbits around of the structures, the fulfilment of the energy conditions and principal stresses (pressure) are analyzed.
Use of deep geothermal energy to supply heat to a village in Scotland
Authors: Penman David , Muhammad-Sukki Firdaus , Abu-Bakar Siti Hawa , Bani Nurul Aini , Mas’ud Abdullahi Abubakar 
Published: February 2025

Abstract
This paper explores the possibility of utilising geothermal energy in an existing district heat network in the Aberdeenshire village of Banchory to provide hot water through the creation of a hypothetical geothermal well. It considers a simulated deep geothermal single well (DGSW), commonly referred to as a coaxial system with a depth of 5000 m. The hypothetical well was created using the dimensions of existing oil wells which, once they have reached the end of their lifecycle, hold the potential to be repurposed for geothermal use. It was found that the thermal output of the well decreases over time due to the drop in local rock temperature which is a result of thermal extraction. Given this, the thermal output after a year of operation was calculated and found that, to directly supply the Banchory heat network, a volumetric flow rate of 4.8m3/hr was required. After a year of operation, the site's peak thermal production was 108.4 kW which equates to a production of more than 949.9 MWh over the first operational year.
Comparison of electrical properties of pure and copper-doped diamond-like carbon interfacial-layered Schottky devices under different temperature conditions
Authors: Şahin Mustafa , Kaymaz Ahmet , Feizollahi Vahid Aylar , Özerden Enise , Altındal Şemsettin 
Published: February 2025

Abstract
In this study, some electrical parameters of the pure and copper-doped diamond-like carbon (DLC) interfacial-layered Schottky devices have been investigated under different temperature conditions. Thus, it was aimed to determine the effects of copper doping on the electrical properties of the devices. Experimental results showed that although different behaviors were observed in both devices in some specific temperature regions, the series resistance values ​​in the copper-doped device gave more stable results depending on the temperature and voltage changes. On the other hand, while the surface states in the DLC interlayered device varied between 1013 and 1014 eV−1 cm−2 levels, lower values (1012–1013 eV−1 cm−2 levels) were observed in the copper-doped device. Moreover, voltage-dependent ideality factor and barrier height exhibited classical behavior as in the literature. However, the copper-doped device still exhibited more stable behaviors. As a result, it has been understood that the electrical properties of the copper-doped device give more regular/stable and higher-quality results.
Raising and head-external relatives in Atchan
Authors: Jarvis Rebecca 
Published: February 2025

Abstract
This paper argues that Atchan (Kwa; Côte d’Ivoire) exhibits raising and head-external relatives. I argue that the two relative clause derivations in Atchan must be separate and do not reflect the cross-linguistically common raising/matching ambiguity: in particular, the non-raising derivation is a head-external one, and Atchan lacks matching-derived relatives. Evidence for two structures comes from negative concord licensing and extraposition, while evidence for the head-external derivation comes from idiom interpretation and word-order possibilities given the complex relative-clause periphery of Atchan. The latter piece of evidence relies on a pattern of relative-clause subject displacement in Atchan, which is shown to force a raising derivation. These phenomena in Atchan serve as evidence for the relevance of the head-external derivation cross-linguistically and, in particular, show that hybrid or other matching-based accounts of relative-clause connectivity cannot be applied universally.
Remarks on Nahm sums for symmetrizable matrices
Authors: Mizuno Yuma 
Published: February 2025

Abstract
Nahm sums are specific q-hypergeometric series associated with symmetric positive definite matrices. In this paper we study Nahm sums associated with symmetrizable matrices. We show that one direction of Nahm’s conjecture, which was proven by Calegari, Garoufalidis, and Zagier for the symmetric case, also holds for the symmetrizable case. This asserts that the modularity of a Nahm sum implies that a certain element in a Bloch group associated with the Nahm sum is a torsion element. During the proof, we investigate the radial asymptotics of Nahm sums. Finally, we provide lists of candidates of modular Nahm sums for symmetrizable matrices based on numerical experiments.