bluuebunny/crossref_metadata_2025_split huggingface dataset:
Desafios na jornada docente: O aparecimento silencioso da Síndrome de Burnout
Authors: GONÇALVES DALILA DA COSTA , Ribeiro Wilian , Gonçalves Débora 
Published: April 2024

A crescente desistência da sala de aula tem demonstrado quão desgastada e desvalorizada tem se tornado a profissão docente. Junto a fatores de pressão por alto desempenho em meio a um cenário pandêmico, o sistema político-educacional produz colapsos psíquicos e físicos em seus profissionais. Discute-se muito acerca da efetividade do ensino e aprendizados dos discentes, contudo, pouco se aborda sobre as condições de trabalho e os reflexos na saúde dos professores. Este artigo tem por objetivo refletir sobre o desgaste dos professores e correlaciona-lo ao aparecimento da Síndrome de Burnout. Baseada em uma revisão de literatura, buscamos compreender e identificar os primeiros sintomas e as consequências físicas e emocionais geradas pelas condições do sistema educacional. O desgaste vocal, físico e mental, extensa jornada de trabalho, além da remuneração insatisfatória, reinvenção pedagógica diante do isolamento social, o não reconhecimento social e a pressão por alta performance em meio a pandemia do Covid-19, são algumas das supostas evidências que podem estar diretamente relacionadas ao desenvolvimento da síndrome de Burnout.
Exome sequencing in extreme altitude mountaineers identifies pathogenic variants in RTEL1 and COL6A1 previously associated with respiratory failure
Authors: Maksiutenko Evgeniia M. , Merkureva Valeriia , Barbitoff Yury A. , Tsay Victoria V. , Aseev Mikhail V. , Glotov Andrey S. , Glotov Oleg S. 
Published: April 2024

AbstractAdaptation of humans to challenging environmental conditions, such as extreme temperature, malnutrition, or hypoxia, is an interesting phenomenon for both basic and applied research. Identification of the genetic factors contributing to human adaptation to these conditions enhances our understanding of the underlying molecular and physiological mechanisms. In our study, we analyzed the exomes of 22 high altitude mountaineers to uncover genetic variants contributing to hypoxic adaptation. To our surprise, we identified two putative loss‐of‐function variants, rs1385101139 in RTEL1 and rs1002726737 in COL6A1 in two extremely high altitude (personal record of more than 8500 m) professional climbers. Both variants can be interpreted as pathogenic according to medical geneticists' guidelines, and are linked to inherited conditions involving respiratory failure (late‐onset pulmonary fibrosis and severe Ullrich muscular dystrophy for rs1385101139 and rs1002726737, respectively). Our results suggest that a loss of gene function may act as an important factor of human adaptation, which is corroborated by previous reports in other human subjects.
Diazoxide and moderate‐intensity exercise improve skeletal muscle function by decreasing oxidants and enhancing antioxidant defenses in hypertensive male rats
Authors: Bravo Sánchez Estefanía , Nolasco Ruíz César J. , Gómez‐Barroso Mariana , Cortés Rojo Christian , Rodríguez Orozco Alain R. , Saavedra Molina Alfredo , Manzo Ávalos Salvador , Montoya Pérez Rocío 
Published: April 2024

AbstractHigh sodium intake is decisive in the incidence increase and prevalence of hypertension, which has an impact on skeletal muscle functionality. Diazoxide is an antihypertensive agent that inhibits insulin secretion and is an opener of KATP channels (adosine triphosphate sensitive potasium channels). For this reason, it is hypothesized that moderate‐intensity exercise and diazoxide improve skeletal muscle function by reducing the oxidants in hypertensive rats. Male Wistar rats were assigned into eight groups: control (CTRL), diazoxide (DZX), exercise (EX), exercise + diazoxide (EX + DZX), hypertension (HTN), hypertension + diazoxide (HTN + DZX), hypertension + exercise (HTN + EX), and hypertension + exercise + diazoxide (HTN + EX + DZX). To induce hypertension, the rats received 8% NaCl dissolved in water orally for 30 days; in the following 8 weeks, 4% NaCl was supplied to maintain the pathology. The treatment with physical exercise of moderate intensity lasted 8 weeks. The administration dose of diazoxide was 35 mg/kg intraperitoneally for 14 days. Tension recording was performed on the extensor digitorum longus and the soleus muscle. Muscle homogenates were used to measure oxidants using fluorescent probe and the activity of antioxidant systems. Diazoxide and moderate‐intensity exercise reduced oxidants and increased antioxidant defenses.
Estimating positional plus-minus in the NBA
Authors: Gong Hua , Chen Su 
Published: April 2024

Abstract
Plus-minus is a widely used performance metric in sports. Players with high plus-minus ratings are often considered more efficient than others. While numerous plus-minus models have emerged since the introduction of adjusted plus-minus in 2004, most of these metrics focus on evaluating player performance at the individual level. In the present study, we follow the plus-minus framework and adopt a hierarchical Bayesian linear model to estimate plus-minus at the position level in the NBA from 2015–16 to 2021–22. Results show that players with versatile offensive skills and big players who defend the paint area are the most valuable offensive and defensive contributors respectively. We also find that the gaps in offensive plus-minus between offensive position groups have decreased over time. Overall, our analysis offers valuable information regarding average positional values in the NBA, allowing more objective player comparisons within position groups. We also show improved prediction accuracy in player plus-minus when factoring in player positions.
A comparative corpus-based ecological discourse analysis of Chinese, Indian, and American news reports on the Belt and Road Initiative (2013–2022)
Authors: Wei Ruby Rong , Hu Yanlan 
Published: April 2024

Abstract
This study employs corpus-based ecological discourse analysis to explore representations of the ecological attitudes in English-language news reports on China’s Belt and Road Initiative (BRI) in China, India, and the United States from 2013 to 2022. It reveals the media’s perception and attitude towards the BRI in these nations. The analysis reveals that media outlets in each country project different ecological stances using varied attitudinal resources. The Chinese media frequently deploy beneficial attitudinal resources to highlight the BRI’s achievements and advocate for broader international engagement. In contrast, the Indian media exhibit a balanced usage of beneficial, neutral, and destructive attitudinal resources, reflecting a prudent and observant attitude towards the BRI. The American media corpus displays a greater prevalence of neutral and destructive attitudinal representations over beneficial ones, suggesting a comparatively skeptical reception of the initiative. The study argues that these divergent patterns of ecological attitudes and the selection of attitudinal resources are shaped by factors such as economic development, geographical context, and social values.
An innovative binocular vision-based method for displacement measurement in membrane structures
Authors: Liu Ping , Wenrui Li , Ngamkhanong Chayut , Kaewunruen Sakdirat 
Published: April 2024

Abstract
This article presents a new binocular vision method for accurate deformation measurements of flexible membrane structures. Using enhanced marker points on the membrane, the method identifies areas for displacement measurements, filtering out unwanted image features with scale-invariant feature transform and threshold correlation. It integrates Canny edge recognition and quadratic weighted averaging for precise positioning of measurement points. By comparing reference images and utilizing the principle of minimum distance between matching points, the method achieves fast matching and determines the three-dimensional coordinates of marker points, enhancing measurement efficiency and robustness. This approach has been empirically tested on membrane structures, providing new insights. The results highlight that our novel algorithm can achieve high-precision measurements down to millimeters, and its accuracy increases with the actual displacement of the membrane structure. Notably, this groundbreaking measurement method remains unaffected by the form of the membrane surface, addressing a long-standing challenge in the field.
Investigating the bioactive compounds from Capsicum annum as a probable alternative therapy for prostate cancer treatment: a structure-based drug design approach
Authors: Abdul-Hammed Misbaudeen , Adedotun Ibrahim Olaide , Ismail Ubeydat Temitope , Ayankoso Saheed Ademola , Abdul-razaq Roqeebah , Olajide Monsurat , Lawal Teslim Alabi 
Published: April 2024

Abstract
Prostate cancer remains a significant global health challenge, necessitating the exploration of novel therapeutic approaches. Androgen receptor (AR) signaling plays a critical role in prostate cancer progression and is a primary target for therapy. This study investigates the potential of phytochemicals from Capsicum annuum (Bell pepper) along with two common standand drugs (Apalutamide and Enzalutamide) as inhibitors of the human androgen receptor (AR) and prostate-specific membrane antigen (PSMA). Utilizing computer-aided drug design techniques, molecular docking studies were conducted to evaluate the binding affinities of selected ligands against AR (PDB ID: 1XOW) and PSMA (PDB ID: 2XEI), their ADMET properties, drug-likeness, oral bioavailability, and bioactivity profiles were also examined. Coumaroylquinic acid and 5-O-caffeoylquinic acid methyl-ester emerged as top-performing ligands, demonstrating strong binding affinities of −9.4 kcal/mol and −9.2 kcal/mol, respectively, against PSMA. Additionally, molecular dynamics simulations provided insights into the stability of protein-ligand complexes, with Coumaroylquinic acid exhibiting a stable binding conformation throughout the simulation. These findings suggest the potential of C. annuum phytochemicals, particularly Coumaroylquinic acid and 5-O-caffeoylquinic acid methyl-ester, as promising inhibitors of PSMA. Moreover, other ligands (Caffeoylglucoside and 1-O-galloyl-beta-d-glucose) identified in the study demonstrate interactions with AR, highlighting a multifaceted approach to prostate cancer treatment. Overall, this study underscores the potential of C. annuum phytochemicals as a source of novel therapeutic agents for prostate cancer, laying the groundwork for further lead optimization efforts.
Auditory encoding of natural speech at subcortical and cortical levels is not indicative of cognitive decline
Authors: Bolt Elena , Giroud Nathalie 
Published: April 2024

More and more patients worldwide are diagnosed with dementia, which emphasizes the urgent need for early detection markers. In this study, we built on the auditory hypersensitivity theory of a previous study—which postulated that responses to auditory input in the subcortex as well as cortex are enhanced in cognitive decline—, and examined auditory encoding of natural continuous speech at both neural levels for its indicative potential for cognitive decline. We recruited study participants aged 60 years and older, who were divided into two groups based on the Montreal Cognitive Assessment, one group with low scores (n = 19, participants with signs of cognitive decline), and a control group (n = 25). Participants completed an audiometric assessment and then we recorded their electroencephalography while they listened to an audiobook and click sounds. We derived Temporal Response Functions and evoked potentials from the data and examined response amplitudes for their potential to predict cognitive decline, controlling for age and hearing loss. Contrary to our expectations, no evidence of auditory hypersensitivity was observed in participants with signs of cognitive decline; response amplitudes were comparable in both cognitive groups. Moreover, the combination of response amplitudes showed no predictive value for cognitive decline. These results challenge the proposed hypothesis and emphasize the need for further research to identify reliable auditory markers for the early detection of cognitive decline.Significance statementResearch on cognitive decline needs more studies uncovering markers for subtle neural changes in the pre-dementia stage. Neural markers for auditory processing have a potential that has not been widely explored in studies. Here, for the first time, we used natural, continuously spoken language to examine neural processing in two groups of older adults with and without cognitive decline. We quantified how well the brain tracks speech not only at the cortical but also at the subcortical level. In contrast to previous research suggesting that subcortical and cortical auditory responses are enhanced in cognitive decline, we found no group differences. We believe that this study represents an important contribution to the search for markers of cognitive health in old age.
Pt–Mo/MWCNT catalysts for desulfurization of extra-heavy crude oil at low temperature
Authors: Torres-Santillan Esther , Ortega-Aviles Mayahuel , Capula-Colindres Selene , Teran Gerardo , Reza-San German Carmen M. , Rojas-Valencia Oscar G. 
Published: April 2024

AbstractPt–Mo nanoparticles supported by MWCNT were synthesized by wet impregnation and applied to desulfurize extra-heavy crude oil. Structural, morphological, and chemical characterizations confirmed uniform dispersion of Pt and Mo on MWCNT surfaces. The Pt–Mo nanoparticles had crystallite sizes ranging from 1.7 to 28 nm. The catalysts were used in the aquathermolysis of UTSIL crude oil, showing good stability and activity. Sulfur was reduced by 50% at 50°C and 80% at 100°C. FT-IR spectroscopy revealed the formation of hydrogenated aromatic rings and a decrease in sulfonic groups during desulfurization.
Graphical abstract
Occupational patterns of opioid-related harms comparing a cohort of formerly injured workers to the general population in Ontario, Canada
Authors: Carnide Nancy , Feng Gregory , Song Chaojie , Demers Paul A. , MacLeod Jill S. , Sritharan Jeavana 
Published: April 2024

Abstract
Objectives
The role of work-related injuries as a risk factor for opioid-related harms has been hypothesized, but little data exist to support this relationship. The objective was to compare the incidence of opioid-related harms among a cohort of formerly injured workers to the general population in Ontario, Canada.

Methods
Workers’ compensation claimants (1983–2019) were linked to emergency department (ED) and hospitalization records (2006–2020). Incident rates of opioid-related poisonings and mental and behavioural disorders were estimated among 1.7 million workers and in the general population. Standardized incidence ratios (SIRs) and 95% confidence intervals (CI) were calculated, adjusting for age, sex, year, and region.

Results
Compared to the general population, opioid-related poisonings among this group of formerly injured workers were elevated in both ED (SIR = 2.41, 95% CI = 2.37–2.45) and hospitalization records (SIR = 1.54, 95% CI = 1.50–1.59). Opioid-related mental and behavioural disorders were also elevated compared to the general population (ED visits: SIR = 1.86, 95% CI = 1.83–1.89; hospitalizations: SIR = 1.42, 95% CI = 1.38–1.47). Most occupations and industries had higher risks of harm compared to the general population, particularly construction, materials handling, processing (mineral, metal, chemical), and machining and related occupations. Teaching occupations displayed decreased risks of harm.

Conclusion
Findings support the hypothesis that work-related injuries have a role as a preventable risk factor for opioid-related harms. Strategies aimed at primary prevention of occupational injuries and secondary prevention of work disability and long-term opioid use are warranted.
Factors and Conditions for the Manifestation of Proactive Behavior in Children Participating in the NTI-Club Movement
Authors: Goshin Mikhail E. , Sorokin Pavel S. 
Published: April 2024

The article is devoted to the study of the types, features, conditions and factors of proactive behavior (agency) of children engaged in various practices of the NTI-Club Movement of Russia. The empirical basis for qualitative sociological analysis was the materials (transcripts) of 53 interviews conducted with schoolchildren participating in the NTI-Club Movement from 2019 to 2022. It is shown that the majority of respondents manifest different levels and forms of agency, including "autonomous", when the subject becomes the initiator of proactive action and "cooperative", manifested in the form of searching and joining a team of like-minded people, or creating organized teams and groups. The main factors contributing to the formation of proactive behavior are the favorable educational environment, the support of the immediate environment, primarily family and parents, as well as classmates, friends and teammates. An important role is that of a mentor, a professional in his field, which consists in introducing the child to certain resources where he/her can independently search for information, inspire and motivate the child. It was important to reveal the detached parental position, which leads to two possible variants of the child's development: either unwillingness to do anything, or development and implementation despite the lack of parental support. The main external barriers hindering the implementation of agency are the school, which puts forward formal educational requirements, as well as the strictly controlling, limiting position of parents. Internal barriers are lack of motivation, uncertainty and fear of the future, as well as the need to overcome one's own inertia. The important fixation of the interview was the idea about two basic motives for the development of proactive behavior (agency). One is a focus on personal well-being, and the other is a public good, which as a rule do not contradict each other, can complement each other, be implemented jointly.
An Initial Feasibility Trial of Providing Yoga in School for Children with Additional Support Needs
Authors: Hart Niamh Claire , Booth Josie N. , Löppönen Heini , Sivaramakrishnan Divya , Fawkner Sam 
Published: April 2024

Abstract
Yoga is used widely as a therapeutic tool for physical and mental well-being. However, greater understanding of the effect yoga may have on young people who require additional support for learning is warranted. Therefore, the aim of the present study was to assess the feasibility of delivering and evaluating an 8-week school-based yoga program targeted to children with additional support needs in a mainstream primary school. Data were collected from 11 pupils (aged 4–12) with additional support needs. The Behavior Rating Inventory of Executive Function and Strengths and Difficulties Questionnaire were completed pre- and postintervention by parents and the pupil's schoolteachers. Observation of the yoga class engagement was conducted at baseline, midway through, and at the end of the intervention. A visual adaptation of the Children's Feeling Scale was completed each week pre– and post–yoga class by each student. Qualitative measures, including a parent feedback questionnaire, interview with the yoga instructor, and focus group with the pupil support assistants, were undertaken. The program was delivered as planned. The yoga instructor, parents, and pupil support assistants found the program to be beneficial to the students and a feasible part of their school week. There were no significant differences pre- to postintervention in any scores of the Strengths and Difficulties Questionnaire or Behavior Rating Inventory of Executive Function. Some positive changes in mood were found, although effect sizes were small. This study demonstrates the feasibility of delivering a school-based yoga program for children with additional support needs, as well as a feasible evaluation approach. The overall experiences for pupils, pupil support assistants, and the yoga teacher were positive and suggest that wider implementation and evaluation of the school-based yoga program would be of value.
Comparative analysis of the methods of an all-endoscopic brachial plexus decompression and a mini-invasive endoscopically-assisted technique for management of patients with traumatic brachioplexopathy
Authors: Belyak E. A. , Sagdiev R. Kh. , Lazko F. L. , Sufianov A. A. , Paskhin D. L. , Prizov A. P. , Lazko M. F. , Zagorodniy N. V. 
Published: April 2024

Introduction As reported, brachioplexopathy is a relevant polyetiological disease with an annual incidence from 0.17 to 1.6 per 100,000. There are two basic endoscopic methods of brachial plexus decompression: an endoscopically-assisted mini-invasive transaxillary approach and fully endoscopic decompression in association with shoulder arthroscopy.Purpose Compare the two main endoscopic methods of brachial plexus decompression.Material and methods Twenty-two patients diagnosed with post-traumatic brachioplexopathy were included in the study. There were 8 patients in group 1 and 14 patients in group 2. All patients passed clinical and instrumental examination. Statistical analysis was performed with non-parametric U-criteria of Mann – Whitney. Differences were considered significant at p < 0.05. Patients of group 1 underwent shoulder joint arthroscopy and fully endoscopic brachial plexus decompression. Patients of group 2 had revision and transaxillary mini-invasive decompression of brachial plexus with video endoscopic assistance.Results In the first group, upper limb dysfunction according to DASH scale decreased from 52.3 ± 2.2 to 28.8 ± 3.8 points (p < 0.05). In the second group, upper limb dysfunction according to DASH scale decreased from 47.9 ± 4.4 to 26.6 ± 4.3 points (p < 0.05). Discrepancy according to DASH scale before and after surgery in the first group was 23.5 ± 3.6 points and in the second group it was 19.4 ± 5.4 points; the difference between the groups was statistically insignificant (p > 0.05).Discussion The results of our study are similar to the results of endoscopic brachial plexus decompression in the previously published studies.Conclusion The methods of endoscopic brachial plexus decompression in association with shoulder joint arthroscopy and isoolated mini-invasive neurolysis and decompression of brachial plexus under videoendoscopic assistance are equally effective in the treatment of brachialplexopathy.