bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stabilization of halide perovskites with silicon compounds for optoelectronic, catalytic, and bioimaging applications
Authors: Jana Atanu , Cho Sangeun , Meena Abhishek , Ahmed Abu Talha Aqueel , Sree Vijaya Gopalan , Park Youngsin , Kim Hyungsang , Im Hyunsik , Taylor Robert A. 
Published: May 2024

AbstractSilicon belongs to group 14 elements along with carbon, germanium, tin, and lead in the periodic table. Similar to carbon, silicon is capable of forming a wide range of stable compounds, including silicon hydrides, organosilicons, silicic acids, silicon oxides, and silicone polymers. These materials have been used extensively in optoelectronic devices, sensing, catalysis, and biomedical applications. In recent years, silicon compounds have also been shown to be suitable for stabilizing delicate halide perovskite structures. These composite materials are now receiving a lot of interest for their potential use in various real‐world applications. Despite exhibiting outstanding performance in various optoelectronic devices, halide perovskites are susceptible to breakdown in the presence of moisture, oxygen, heat, and UV light. Silicon compounds are thought to be excellent materials for improving both halide perovskite stability and the performance of perovskite‐based optoelectronic devices. In this work, a wide range of silicon compounds that have been used in halide perovskite research and their applications in various fields are discussed. The interfacial stability, structure–property correlations, and various application aspects of perovskite and silicon compounds are also analyzed at the molecular level. This study also explores the developments, difficulties, and potential future directions associated with the synthesis and application of perovskite‐silicon compounds.image
Evaluation of potential irrigation water savings by assessing the soil water balance in a vineyard in central Chile
Authors: Salazar Osvaldo , Castro Marcela , Singh Ranvir , Ponstein Helena 
Published: May 2024

AbstractThe main aim of this study was to evaluate the potential savings of irrigation water by assessing the soil water balance during the growing season in a wine vineyard in the Maule region, Chile. This study provides insights into the influences of different irrigation water applications on soil water status and its potential effects on grape yields, water use efficiency (WUE) and the cost of irrigation to help improve irrigation practices in the region and other similar Mediterranean regions. The field experiment compared three levels of irrigation water applied: current irrigation of the vineyard (T0) and two deficit irrigation treatments with reductions to 75% (T1) and 50% of the irrigated water (T2). The measurements included volumetric soil water content, shallow groundwater table, canopy cover and grape yield at harvest during the entire growing season (October 2017 to April 2018). We found a potential reduction of 25% or 50% in the current irrigation system while maintaining the grape yield, increasing the WUE and reducing the cost of irrigation. Consideration of the water stored in the soil by the accumulation of rainfall in the winter season and the potential for capillary rise of shallow groundwaters is crucial for adjusting irrigation to vine water requirements.
Olsalazine pretreatment augments chemosensitivity of gemcitabine in hepatocellular carcinoma
Authors: Sharma Ayush , Chhipa Abu Sufiyan , Verma Srashti , Parikh Palak , Patel Snehal 
Published: May 2024

AbstractThe present study was carried out to evaluate the effects of olsalazine pretreatment in the potentiation of chemosensitivity of gemcitabine for the treatment of hepatocellular carcinoma (HCC). In silico molecular docking was performed to analyze the interactions of olsalazine and gemcitabine with DNMT1 and DNA, respectively, using the AutoDock tools 1.5.6. Cytotoxicity of olsalazine, gemcitabine, and combination was measured on human HePG2 cells using MTT assay. Anti‐tumor effects of the combination were assessed using animal model of N‐nitrosodiethylamine and carbon tetrachloride‐induced HCC. Treatment was initiated from 8th week of induction to 11th week and changes in body weight, liver weight (absolute and relative), and survival rate were measured. Following treatment, blood samples were collected for estimation of serum biochemistry. Blood serum was used for the estimation of inflammatory cytokines: tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6), C‐reactive protein [CRP], lactate dehydrogenase (LDH), and P53 levels. Oxidative stress markers were measured in liver tissue homogenates. Histopathology and immunohistochemistry (IHC) were performed on liver sections to detect the morphological changes and P53 expression. Docking analysis revealed the interactions between olsalazine and DNMT1 with a binding energy score of −5.34 and gemcitabine and DNA with a binding energy score of −5.93. Olsalazine pretreatment potentiated the anticancer effects of gemcitabine in cell line study. In the groups receiving olsalazine pretreatment showed significant reductions in relative liver weight and improved survival rate. Serum biochemical markers: serum glutamate pyruvate transaminase, serum glutamic oxaloacetic transaminase, alkaline phosphatase, and bilirubin revealed improved liver functions. Olsalazine pretreatment also reduced the levels of inflammatory markers: CRP, LDH, TNF‐α, and IL‐6 and oxidative stress markers dose dependently. Histopathology and IHC showed improved liver morphology with potentiated induction of P53 upon olsalazine pretreatment in combination with gemcitabine. In conclusion, sequential combination of olsalazine and gemcitabine improved the treatment outcomes during the progression of HCC.
Mitochondria‐specific antioxidant MitoTEMPO alleviates senescence of bone marrow mesenchymal stem cells in ovariectomized rats
Authors: Li Jiayi , Zhang Dahe , Zhang Yuxin , Ge Jing , Yang Chi 
Published: May 2024

AbstractSenescence in bone marrow mesenchymal stem cells (BMSCs), triggered by excessive oxidative stress, plays a crucial role in the onset of postmenopausal osteoporosis. Recent studies underscore the importance of mitochondrial rehabilitation and quality control as key determinants in the modulation of oxidative stress and cellular senescence. MitoTEMPO, a mitochondria‐targeted antioxidant, has been shown to mitigate the heightened levels of reactive oxygen species (ROS). In our research, we observed that BMSCs from ovariectomized (OVX) rats displayed premature senescence, which was attributed to combined mitochondrial and lysosomal dysfunction, a condition that worsens with extended estrogen deprivation. Treatment with MitoTEMPO effectively reversed these effects, reinstating lysosomal functionality and suppressing the mitochondrial unfolded protein response (UPRmt). Subsequent in vivo experiments corroborated these observations, revealing that MitoTEMPO administration in OVX rats curtailed trabecular bone loss and reduced the expression of p53, HSP60, and CLPP in the trabecular bone region of the proximal tibia. Overall, our findings suggest that MitoTEMPO holds promise as a therapeutic agent to counteract senescence in OVX‐BMSCs, offering a potential strategy for treating postmenopausal osteoporosis.
SATB1, senescence and senescence‐related diseases
Authors: Qi Wenjing , Bai Jinping , Wang Ruoxi , Zeng Xianlu , Zhang Lihui 
Published: May 2024

AbstractAging leads to an accumulation of cellular mutations and damage, increasing the risk of senescence, apoptosis, and malignant transformation. Cellular senescence, which is pivotal in aging, acts as both a guard against cellular transformation and as a check against cancer progression. It is marked by stable cell cycle arrest, widespread macromolecular changes, a pro‐inflammatory profile, and altered gene expression. However, it remains to be determined whether these differing subsets of senescent cells result from unique intrinsic programs or are influenced by their environmental contexts. Multiple transcription regulators and chromatin modifiers contribute to these alterations. Special AT‐rich sequence‐binding protein 1 (SATB1) stands out as a crucial regulator in this process, orchestrating gene expression by structuring chromatin into loop domains and anchoring DNA elements. This review provides an overview of cellular senescence and delves into the role of SATB1 in senescence‐related diseases. It highlights SATB1's potential in developing antiaging and anticancer strategies, potentially contributing to improved quality of life and addressing aging‐related diseases.
Cotton SNARE complex component GhSYP121 regulates salicylic acid signaling during defense against Verticillium dahliae
Authors: Gao Linying , Pei Yakun , Wang Ping , Cen Yuhan , Yan Xin , Hou Yuxia 
Published: May 2024

AbstractSyntaxin of plant (SYP) plays a crucial role in SNARE‐mediated membrane trafficking during endocytic and secretory pathways, contributing to the regulation and execution of plant immunity against pathogens. Verticillium wilt is among the most destructive fungal diseases affecting cotton worldwide. However, information regarding SYP family genes in cotton is scarce. Through genome‐wide identification and transcriptome profiling, we identified GhSYP121, a Qa SNARE gene in Gossypium hirsutum. GhSYP121 is notably induced by Verticillium dahliae, the causal agent of Verticillium wilt in cotton, and acts as a negative regulator of defense against V. dahliae. This is evidenced by the reduced resistance of GhSYP121‐deficient cotton and the increased susceptibility of GhSYP121‐overexpressing lines. Furthermore, the activation of the salicylic acid (SA) pathway by V. dahliae is inversely correlated with the expression level of GhSYP121. GhSYP121 interacts with its cognate SNARE component, GhSNAP33, which is required for the penetration resistance against V. dahliae in cotton. Collectively, GhSYP121, as a member of the cotton SNARE complex, is involved in regulating the SA pathway during plant defense against V. dahliae. This finding enhances our understanding of the potential role of GhSYP121 in these distinct pathways that contribute to plant defense against V. dahliae infection.
Iron ion catalyzed hydrogen peroxide pretreatment for bio‐jet fuel production from straw biomass
Authors: Zhu Rui , Zhang Rui , He Yuting , Zhu Can , Jiang Yu , Ni Yuming , Fan Minghui , Li Quanxin 
Published: May 2024

AbstractBACKGROUNDThe development of efficient and green pretreatment pathway is of great significance for promoting biofuel production from lignocellulosic waste. The purpose of this work was to evaluate that iron ion‐catalyzed hydrogen peroxide pretreatment can be used as an environmentally friendly pretreatment way for bio‐jet fuel production using straw.RESULTSThe effects of iron ion‐catalyzed hydrogen peroxide pretreatment (Fe‐HP) on the enzymatic hydrolysis, fermentation and bio‐jet fuel production using straw were investigated. It was found that the iron ion‐catalyzed hydrogen peroxide pretreatment significantly improved the enzymatic hydrolysis and fermentation efficiency of straw biomass. Subsequently, the directional catalytic transformation of straw‐derived fermentation broth to bio‐jet fuels was achieved using a dual functional catalyst (HSAPO34/NiHBET). High conversion (94.9%) and good jet‐fuel selectivity (77.3%) were obtained in the conversion process of straw. On account of the biomass characterization and the analysis of reactive oxygen species during the Fe‐HP pretreatment, the role and mechanism of the Fe‐HP pretreatment was addressed.CONCLUSIONThe Fe‐HP pretreatment can be used as an environmentally friendly pretreatment way for jet fuel production from straw biomass. Fe‐HP pretreatment increased sugar yield and sugar concentration during enzymatic hydrolysis, which was beneficial for subsequent fermentation and bio‐jet fuel production. The reactive oxygen species take a prominent role in the Fe‐HP pretreatment of lignocellulose. © 2024 Society of Chemical Industry (SCI).
The LTAR Integrated Grazing Land Common Experiment at the Texas Gulf
Authors: Schantz Merilynn C. , Smith Douglas R. , Harmel Daren , Goodwin Douglas J. , Tolleson Doug R. , Leyton Javier M. Osorio , Flynn K. Colton , Yost Jenifer L. , Thorp Kelly R. , Arnold Jeffrey G. , White Michael J. , Adhikari Kabindra , Hajda Chad 
Published: May 2024

AbstractExtreme weather and climate events have become more frequent and directly affect the ecological structure and function of integrated grazing lands. While the Great Plains have experienced a long history of regular disturbances from drought and floods, grazing, and fires, the increased frequency and magnitude of these disturbances can reduce ecological resilience, largely depending on management practices. Alternative strategies designed to adaptively manage grazing land resources based on the ecology of the system should increase the resistance and resilience to disturbances when compared to prevailing practices. Determining the ecologic and economic value of alternative strategies will require long‐term evaluations across large spatial scales. The Long‐Term Agroecosystem Research network has been established to evaluate the differences between alternative and prevailing practices among 18 strategically located sites and across decadal time scales throughout the continental United States. A key integrated grazing land site within this network is the Texas Gulf located at the Riesel Watersheds in the Blackland Prairie of Central Texas. At this study site, the differences between alternative and prevailing grazing management strategies are now being evaluated. The alternative strategy was designed using a combination of knowledge of the site and species ecology with modern‐day tools and technologies. Alternatively, the prevailing practice implements a conventional year‐round continuous grazing system with heavy reliance on hay and supplemental protein during winter. Results will provide grazing land managers with economically viable adaptive management choices for increasing ecological resilience following extreme and frequent disturbance events.
Green HRM practices and green work engagement: The roles of green knowledge sharing and green group cohesion
Authors: Haque Md Anamul , Islam Md Asadul , Soh SoonHu 
Published: May 2024

AbstractDrawing on social exchange theory (SET) and job demand‐resource (JD‐R) theory, the purpose of this study is to examine the role of green knowledge sharing and green group cohesion in the context of green practices and green work engagement. Data analysis of the 392 respondents working in managerial positions at RMG factories in Bangladesh shows that green competency‐building practices have a significant relationship with green work engagement. However, the study has not found any relationship between green performance management practices, green involvement practices, and green work engagement. Nevertheless, the study shows that green knowledge sharing mediates the relationship between green practices and green work engagement. Furthermore, this study's contribution to SET and JD‐R theories is referred to as “green group cohesion” as we have found it to be a significant moderator in the indirect relationship between green competency‐building practices, green performance management practices, green involvement practices, and green work engagement through green knowledge sharing. The findings have implications for the theories and practices that are discussed.
Do mid‐level providers enhance hospital cost per discharge or triple aim performance efficiency? An exploratory analysis
Authors: Bonnett Aaron W. , Heim Gregory R. 
Published: May 2024

AbstractHospital administrators are shifting care delivery models toward an approach that uses more caregivers in the form of mid‐level providers (MLPs), such as nurse practitioners, physician assistants, and clinical nurse specialists. To date, however, healthcare operations management (OM) literature remains ambiguous about longitudinal empirical associations between mid‐level providers and hospital costs, quality, and other performance measures. We analyze how the extent of MLP employment used by a hospital is associated with hospital operational outcomes, as reflected by hospital cost per discharge and Triple Aim Performance (TAP) efficiency metrics. Our findings indicate percent MLP usage is positively associated with efficiency metrics for hospital clinical quality, technical efficiency, and patient experience, but not associated with hospital costs. We also find percent MLP usage is associated with the likelihood that hospitals excel on all TAP metrics simultaneously. Post‐hoc exploratory analyses suggest the associations exhibit differential outcomes across hospital efficiency quantiles, while sub‐sample analyses motivate boundary conditions for some hypothesized MLP associations. We contribute to healthcare OM research by providing one of the first panel data analyses of MLPs, improving insights relative to extant work. By giving key stakeholders useful findings about outcomes associated with hospital staffing trends, our managerial contribution helps hospital administrators understand empirical consequences of the increasing use of MLPs.
Juvenile polyposis syndrome in children: The impact of SMAD4 and BMPR1A mutations on clinical phenotype and polyp burden
Authors: Cohen Shlomi , Yerushalmy‐Feler Anat , Rojas Isabel , Phen Claudia , Rudnick David A. , Flahive Colleen B. , Erdman Steven H. , Magen‐Rimon Ramit , Copova Ivana , Attard Thomas , Latchford Andrew , Hyer Warren 
Published: May 2024

AbstractObjectiveA constitutional disease‐causing variant (DCV) in the SMAD4 or BMPR1A genes is present in 40%–60% of patients with juvenile polyposis syndrome (JPS). The aim of this study was to characterize the clinical course and polyp burden in children with DCV‐positive JPS compared to DCV‐negative JPS.MethodsDemographic, clinical, genetic, and endoscopic data of children with JPS were compiled from eight international centers in the ESPHGAN/NASPGHAN polyposis working group.ResultsA total of 124 children with JPS were included: 69 (56%) DCV‐negative and 55 (44%) DCV‐positive (53% SMAD4 and 47% BMPR1A) with a median (interquartile range) follow‐up of 4 (2.8–6.4) years. DCV‐positive children were diagnosed at an older age compared to DCV‐negative children [12 (8–15.7) years vs. 5 (4–7) years, respectively, p < 0.001], had a higher frequency of family history of polyposis syndromes (50.9% vs. 1.4%, p < 0.001), experienced a greater frequency of extraintestinal manifestations (27.3% vs. 5.8%, p < 0.001), and underwent more gastrointestinal surgeries (16.4% vs. 1.4%, p = 0.002). The incidence rate ratio for the development of new colonic polyps was 6.15 (95% confidence interval 3.93–9.63, p < 0.001) in the DCV‐positive group compared to the DCV‐negative group, with an average of 12.2 versus 2 new polyps for every year of follow‐up. There was no difference in the burden of polyps between patients with SMAD4 and BMPR1A mutations.ConclusionsThis largest international cohort of pediatric JPS revealed that DCV‐positive and DCV‐negative children exhibit distinct clinical phenotype. These findings suggest a potential need of differentiated surveillance strategies based upon mutation status.
Evaluation of the clinical impact of decreasing the maximum osmolarity of neonatal peripheral parenteral nutrition
Authors: Szachnowicz Brooke , Chalk Bethany , Allan Kari , Lochen Heidi , Liang Caroline 
Published: May 2024

AbstractObjectiveTo describe the clinical impact of lowering the peripheral parenteral nutrition (PPN) maximum osmolarity limit from 1000 to 900 mOsm/L in patients in two neonatal intensive care units (NICUs).MethodsThis was a retrospective cohort study including inborn neonates that received PPN for at least 3 consecutive days within the first 14 days of life. Data were evaluated to compare the ability of PPN with a maximum osmolarity limit of 1000 to 900 mOsm/L to provide daily recommended macronutrient doses, and daily recommended goal calories, as well as to compare the incidence of significant peripheral intravenous (PIV) infiltrates.ResultsA total of 200 PPN orders representing 57 patients were included for analysis, with 100 PPN orders in each osmolarity cohort. Baseline characteristics were similar between the two cohorts. Significantly more PPN orders met goal amino acid doses (45% vs. 24%, p = 0.003) and goal intravenous fat emulsion (IVFE) doses (61% vs. 37%, p = 0.001) in the 1000 mOsm/L osmolarity limit cohort compared to the 900 mOsm/L osmolarity limit cohort. A total of three patients received hyaluronidase for PN infiltration, two in the 1000 mOsm/L osmolarity limit and one in the 900 mOsm/L osmolarity limit cohort (p = 0.6).ConclusionA lower PPN osmolarity limit of 900 mOsm/L significantly limited the ability to provide goal amino acid and IVFE doses to NICU patients compared to the previous osmolarity limit of 1000 mOsm/L without reducing the incidence of PIV infiltration or extravasation.
Impact of early primary care physician follow‐up on hospital readmission following gastrointestinal cancer surgery
Authors: Khalil Mujtaba , Woldesenbet Selamawit , Munir Muhammad Musaab , Khan Muhammad Muntazir Mehdi , Rashid Zayed , Altaf Abdullah , Katayama Erryk , Dillhoff Mary , Tsai Susan , Pawlik Timothy M. 
Published: May 2024

AbstractBackgroundWe sought to examine the association between primary care physician (PCP) follow‐up on readmission following gastrointestinal (GI) cancer surgery.MethodsPatients who underwent surgery for GI cancer were identified using the Surveillance, Epidemiology and End Results (SEER) database. Multivariable regression was performed to examine the association between early PCP follow‐up and hospital readmission.ResultsAmong 60 957 patients who underwent GI cancer surgery, 19 661 (32.7%) visited a PCP within 30‐days after discharge. Of note, patients who visited PCP were less likely to be readmitted within 90 days (PCP visit: 17.4% vs. no PCP visit: 28.2%; p < 0.001). Median postsurgical expenditures were lower among patients who visited a PCP (PCP visit: $4116 [IQR: $670–$13 860] vs. no PCP visit: $6700 [IQR: $870–$21 301]; p < 0.001). On multivariable analysis, PCP follow‐up was associated with lower odds of 90‐day readmission (OR: 0.52, 95% CI: 0.50–0.55) (both p < 0.001). Moreover, patients who followed up with a PCP had lower risk of death at 90‐days (HR: 0.50, 95% CI: 0.40–0.51; p < 0.001).ConclusionPCP follow‐up was associated with a reduced risk of readmission and mortality following GI cancer surgery. Care coordination across in‐hospital and community‐based health platforms is critical to achieve optimal outcomes for patients.