bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of ultrasound‐guided core‐needle biopsy in the assessment of head and neck lesions: A meta‐analysis and systematic review of the literature
Authors: Novoa Eva , Gürtler Nicolas , Arnoux André , Kraft Marcel 
Published: September 2011

AbstractBackgroundCore‐needle biopsy (CNB) has occasionally been used in the work‐up of head and neck lesions. However, no systematic review of this simple, minimally invasive method has yet been performed.MethodsA systematic review of the literature and meta‐analysis of data extracted from 16 included studies were performed. A total of 1291 cervical lesions in 1267 patients were examined by CNB. This resulted in 1232 adequate samples, from which 554 were subsequently confirmed by excisional biopsy.ResultsCNB was able to identify true neoplasms and detect malignancy in head and neck lesions with an overall accuracy of 94% and 96%, respectively, even though there was a significant difference between the histologically verified and all adequate samples. CNB provided a correct specific diagnosis in 87% of cases without major complications and achieved a higher accuracy than that of fine‐needle aspiration in detecting malignancy.ConclusionsThis meta‐analysis confirms that CNB is an excellent method in the assessment of salivary gland lesions and lymphadenopathies inclusive of malignant lymphoma, but it is not ideal for evaluating thyroid lesions. Head Neck, 2011
Observer variation in the histopathologic assessment of extranodal tumor spread in lymph node metastases in the neck
Authors: van den Brekel Michiel W. M. , Lodder Wouter L. , Stel Herbert V. , Bloemena Elisabeth , Leemans C. René , van der Waal Isaäc 
Published: September 2011

AbstractBackgroundExtranodal spread (ENS) of tumors is widely used as a prognosticator for patients with head and neck cancer and is used as an indicator for postoperative treatment. However, the histopathologic agreement among pathologists on the assessment of the presence or absence of this criterion has never been studied.MethodsThe interobserver and intraobserver agreement among 10 pathologists on the diagnosis of ENS in 41 tumor‐positive lymph nodes was evaluated.ResultsThe kappa value of the interobserver agreement among pathologists varied between 0.14 and 0.75, the overall kappa value was 0.42 and 0.49 in the 2 scoring sessions. The intraobserver kappa value varied between 0.49 and 0.95.ConclusionThe intraobserver and interobserver agreement among pathologists in the assessment of the presence of ENS was low in metastatic lymph nodes in the neck. Because of the widely accepted prognostic significance and therapeutic consequences of ENS, there is a need for internationally accepted reproducible criterion for the histopathologic assessment of ENS in metastatic lymph nodes in the neck. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Serum thyrotropin as a risk factor for thyroid malignancy in euthyroid subjects with thyroid micronodule
Authors: Moon Seong‐Su , Lee Young‐Sil , Lee In‐Kyu , Kim Jung‐Guk 
Published: September 2011

AbstractBackgroundAn elevated thyroid stimulating hormone (TSH) level is a risk factor for differentiated thyroid cancer. The present study investigated whether TSH is a risk factor for thyroid microcarcinoma (TMC) in euthyroid subjects with a micronodule.MethodsIn this cross‐sectional study, 483 euthyroid subjects (77 males patients, 406 females patients) with a thyroid micronodule were enrolled and underwent ultrasound guided fine‐needle aspiration biopsy. Serum TSH level was measured in every subject. The final diagnostic outcome (malignant or benign) was defined in conjunction with cytology and histology.ResultsCompared with the patients below the population mean, patients above the population mean had a significantly higher malignancy rate (10.8% vs 4.8%, p = .025). Multiple logistic regression analysis revealed TSH as an independent risk factor for malignancy in euthyroid patients with a micronodule (odds ratio, 1.449; 95% confidence interval, 1.033–2.033; p = .031).ConclusionsMeasurement of TSH in subjects with a thyroid micronodule is helpful to estimate cancer risk. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Voice quality after organ‐preservation therapy with definitive radiotherapy for laryngeal cancer
Authors: Lau Valerie H. , Leonard Rebecca J. , Goodrich Susan , Luu Quang , Farwell D. Gregory , Lau Derick H. , Purdy James A. , Chen Allen M. 
Published: September 2011

AbstractBackgroundThe purpose of this study was to analyze voice quality among patients treated by definitive radiotherapy for laryngeal cancer.MethodsTen patients with laryngeal cancer who had completed radiotherapy were involved in this pilot study. A standardized protocol was administered assessing: (1) sustained vowel production following maximal inspiration, (2) sustained vowel production for a 7‐second duration repeated 5 times, and (3) spontaneous speech for 10 seconds.ResultsThe acoustic parameters among patients with early‐stage cancer were not statistically different from healthy age‐corresponding controls, except for shimmer (0.20 vs 0.16 dB, ρ = 0.01) and maximum phonation duration (24.37 vs 30.10 seconds, ρ = 0.04). For patients with locally advanced cancer, differences with controls were observed with shimmer (2.29 vs 0.16 dB, ρ = 0.01), jitter (7.49% vs 1.04%, ρ = 0.01), harmonics‐to‐noise ratio (2.67 vs 9.22, ρ = 0.01), and maximum phonation duration (14.12 vs 30.10 seconds, ρ = 0.01).ConclusionsDespite the subtle differences in voice quality that existed, radiotherapy as a curative treatment for laryngeal cancer allows maintenance of a functional voice. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Incidence and survival in patients with sinonasal cancer: A historical analysis of population‐based data
Authors: Turner Justin H. , Reh Douglas D. 
Published: September 2011

AbstractBackgroundThe present study uses population‐based data from the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the behavior of sinonasal tumors.MethodsData for all sinonasal malignancies reported between 1973 and 2006 (n = 6739) were extracted from the database. Time‐dependent trends in incidence and survival were analyzed by linear regression.ResultsThe overall incidence of sinonasal cancer was 0.556 cases per 100,000 population per year with a male:female ratio of 1.8:1. The most common histologies were squamous cell carcinoma (51.6%) and adenocarcinoma (12.6%), whereas the most common primary sites were the nasal cavity (43.9%) and maxillary sinus (35.9%). The incidence of sinonasal cancer remained relatively stable during the study period. No significant changes in overall relative survival were noted. The best relative survival was noted in patients treated with surgery or a combination of surgery and radiotherapy.ConclusionsThe prognosis of patients with sinonasal cancer is generally poor, and has not changed substantially over the last 3 decades. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Skull base surgery for pediatric parameningeal sarcomas
Authors: Deneuve Sophie , Teissier Natacha , Jouffroy Thomas , Helfre Sylvie , Boissonnet Hervé , Freneaux Paul , Peuchmaur Michel , Brisse Hervé , Van Den Abbeele Thierry , Orbach Daniel 
Published: September 2011

AbstractBackgroundLocalized pediatric parameningeal sarcomas are usually treated exclusively by chemotherapy and radiotherapy. In this location, surgery is complicated but sometimes attempted to improve local control.MethodsA retrospective bicentric study was conducted to examine its place with particular reference to acute and long‐term morbidity. Fifteen patients under the age of 20 years with parameningeal sarcoma underwent surgery between 2000 and 2007.ResultsSurgery was performed for 8 primary sarcomas and 7 radiation‐induced sarcomas, mainly in infratemporal fossa. Three children had intracranial extension, 3 had metastases, and 1 had both. Median follow‐up was 46 months (16–154 months). Five children experienced local relapse. Eight presented sequelae. Eleven children are alive with no evidence of disease, and 4 died.ConclusionSkull base surgery should be considered as a possible treatment in pediatric parameningeal sarcomas. Surgery is the only option in radiation‐induced sarcoma. Larger studies are necessary to more clearly define surgical indications. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Evaluation of a probabilistic approach to simulation of alkalinity and electrical conductivity at a river bank filtration site
Authors: Thakur A. K. , Singh V. P. , Ojha C. S. P. 
Published: September 2011

AbstractIn river bank filtration, impurities present in the river water travel with the bank filtrate towards the pumping well. During this passage, certain types of impurities, such as turbidity, total coliform, and so forth, may get attenuated; however, it is interesting to note that some of the instant raw river water quality parameters, such as alkalinity and electrical conductivity, increase after the passage of water through the porous medium. This occurs because water, when passing through the soil pores, absorbs many of the solutes that cause an increase in alkalinity and electrical conductivity. Measurements at a river bank filtration site for a year showed that alkalinity of 116–32 mg l−1 in river water increased to 222.4–159.9 mg l−1 in the river bank filtered water. Likewise, the electrical conductivity increased from 280–131 μS cm−1 to 462–409.6 μS cm−1. This study uses a probabilistic approach for investigating the variation of alkalinity and electrical conductivity of source water that varies with the natural logarithm of the concentration of influent water. The probabilistic approach has the potential of being used in simulating the variation of alkalinity and electrical conductivity in river bank filtrate. Copyright © 2011 John Wiley & Sons, Ltd.
Groundwater–surface water interactions in a lowland watershed: source contribution to stream flow
Authors: Guinn Garrett C. , Vulava Vijay M. , Callahan Timothy J. , Jones Martin L. 
Published: September 2011

AbstractThe lower coastal plain of the Southeast USA is undergoing rapid urbanisation as a result of population growth. Land use change has been shown to affect watershed hydrology by altering stream flow and, ultimately, impairing water quality and ecologic health. However, because few long‐term studies have focused on groundwater–surface water interactions in lowland watersheds, it is difficult to establish what the effect of development might be in the coastal plain region. The objective of this study was to use an innovative improvement to end‐member mixing analysis (EMMA) to identify time sequences of hydrologic processes affecting storm flow. Hydrologic and major ion chemical data from groundwater, soil water, precipitation and stream sites were collected over a 2‐year period at a watershed located in USDA Forest Service's Santee Experimental Forest near Charleston, South Carolina, USA. Stream flow was ephemeral and highly dependent on evapotranspiration rates and rainfall amount and intensity. Hydrograph separation for a series of storm events using EMMA allowed us to identify precipitation, riparian groundwater and streambed groundwater as main sources to stream flow, although source contribution varied as a function of antecedent soil moisture condition. Precipitation, as runoff, dominated stream flow during all storm events while riparian and streambed groundwater contributions varied and were mainly dependent on antecedent soil moisture condition. Sensitivity analyses examined the influence of 10% and 50% increases in analyte concentration on EMMA calculations and found that contribution estimates were very sensitive to changes in chemistry. This study has implications on the type of methodology used in traditional forms of EMMA research, particularly in the recognition and use of median end‐member water chemistry in hydrograph separation techniques. Potential effects of urban development on important hydrologic processes (groundwater recharge, interflow, runoff, etc.) that influence stream flow in these lowland watersheds were qualitatively examined. Copyright © 2011 John Wiley & Sons, Ltd.
Investigation of karstic hydrological processes of Niangziguan Springs (North China) using wavelet analysis
Authors: Hao Yonghong , Liu Guoliang , Li Huamin , Li Zhongtang , Zhao Jiaojuan , J. Yeh Tian‐Chyi 
Published: September 2011

AbstractNiangziguan Spring complex is the largest karst spring in North China. We investigate the karst hydrological processes by using Morlet wavelet transform analysis and cross wavelet analysis based on monthly precipitation from 1958 to 2010 and spring discharge from 1958 to 2009. From Morlet wavelet transform coefficients of precipitation and the spring discharge in Niangziguan Springs Basin, we find that the precipitation and discharge are characterized by the multi‐scale features in the time domain, and the energy distribution of the signal is highly irregular across scales. Although precipitation eventually becomes spring discharge by infiltrating and propagating through karst formations, the signals are attenuated. The results also show that the precipitation of Niangziguan Springs Basin has the main periodic components of 1‐, 5‐, 12‐, and 17‐year periods with alternating wet–drought cycle. Similarly, the spring discharge of Niangziguan Springs has the main components of 17‐year periods, but the 1‐, 5‐, and 12‐year periodicity of precipitation are not reflected in spring discharge, which is filtered by the aquifers. The results of cross wavelet analysis reveal that the precipitation and spring discharge share the common periodicity of 17 years. This means that those signals with high energy and long timescales can penetrate through the aquifer and be reflected in spring discharge, whereas other signals are filtered and modified. Copyright © 2011 John Wiley & Sons, Ltd.
Raindrop‐induced saltation and the enrichment of sediment discharged from sheet and interrill erosion areas
Authors: Kinnell P. I. A. 
Published: September 2011

AbstractSheet and interrill erosion areas are sources of soil material rich in nutrients and pollutants. The loss of soil, nutrients and other chemicals from these areas is a matter of concern both in terms of maintaining soil productivity and the health of offsite environments. Many experiments on rainfall erosion have shown enrichment of fine material, nutrients and other chemicals in the sediment discharged for sheet and interrill erosion areas, but often these results were obtained over short periods of time. A qualitative mechanistic model of raindrop‐induced saltation is used to illustrate how this transport mechanism influences the composition of sediment discharged by rain‐impacted flow. Initially, fast moving particles are enriched in the sediment discharge but, over time, during a rainfall event, slower moving particles become more represented. Raindrop‐induced saltation promotes the storage of material on the soil surface with a coarser composition than the original soil. Winnowing of material from this storage by the development of flow‐driven saltation during high‐intensity events can modify the composition of the sediment discharged later by raindrop‐induced saltation. Given stable soil particles, the composition of the sediment discharged at the steady state is the same as the original soil. Enrichment is a non‐steady‐state phenomenon and failure to recognize the transient nature of enrichment may lead to inappropriate interpretation of the implications of the results from short‐term experiments. Copyright © 2011 John Wiley & Sons, Ltd.
Effects of spatial aggregation of soil spatial information on watershed hydrological modelling
Authors: Li Runkui , Zhu A‐Xing , Song Xianfeng , Li Baolin , Pei Tao , Qin Chengzhi 
Published: September 2011

AbstractMany researchers have examined the impact of detailed soil spatial information on hydrological modelling due to the fact that such information serves as important input to hydrological modelling, yet is difficult and expensive to obtain. Most research has focused on the effects at single scales; however, the effects in the context of spatial aggregation across different scales are largely missing. This paper examines such effects by comparing the simulated runoffs across scales from watershed models based on two different levels of soil spatial information: the 10‐m‐resolution soil data derived from the Soil‐Land Inference Model (SoLIM) and the 1:24000 scale Soil Survey Geographic (SSURGO) database in the United States. The study was conducted at three different spatial scales: two at different watershed size levels (referred to as full watershed and sub‐basin, respectively) and one at the model minimum simulation unit level. A fully distributed hydrologic model (WetSpa) and a semi‐distributed model (SWAT) were used to assess the effects. The results show that at the minimum simulation unit level the differences in simulated runoff are large, but the differences gradually decrease as the spatial scale of the simulation units increases. For sub‐basins larger than 10 km2 in the study area, stream flows simulated by spatially detailed SoLIM soil data do not significantly vary from those by SSURGO. The effects of spatial scale are shown to correlate with aggregation effect of the watershed routing process. The unique findings of this paper provide an important and unified perspective on the different views reported in the literature concerning how spatial detail of soil data affects watershed modelling. Different views result from different scales at which those studies were conducted. In addition, the findings offer a potentially useful basis for selecting details of soil spatial information appropriate for watershed modelling at a given scale. Copyright © 2011 John Wiley & Sons, Ltd.
Cost‐effectiveness of KRAS testing in metastatic colorectal cancer patients in the United States and Germany
Authors: Vijayaraghavan Arthi , Efrusy Molly B. , Göke Burkhard , Kirchner Thomas , Santas Christopher C. , Goldberg Richard M. 
Published: September 2011

AbstractThe objective of this study was to determine the cost‐effectiveness of testing for KRAS mutations before administering EGFR inhibitors such as cetuximab and panitumumab for patients with advanced metastatic colorectal cancer (mCRC) in the United States and Germany. We developed a lifetime Markov model of costs and survival associated with treating mCRC patients to assess the impact of KRAS testing before administering EGFR inhibitor‐containing chemotherapy regimens. Overall, combination therapies involving cetuximab plus irinotecan/FOLFIRI had a better life expectancy (25.83 weeks) than cetuximab or panitumumab alone. Use of KRAS testing (assuming KRAS mutant patients receive only irinotecan) was equally effective and saved $12,428 per patient in the United States. When KRAS mutant patients received best supportive care, the life expectancy decreased slightly (24.26 weeksvs. 25.83 weeks) and the costs decreased by $13,501 in the United States and €9,560 in Germany. For patients treated with cetuximab alone, use of KRAS testing to identify mutations lowered costs by $8,040 per patient in the U.S. analysis and €3,856 per patient in the German analysis. For patients treated with panitumumab alone, use of KRAS testing to identify mutations lowered costs by $7,546 per patient in the U.S. analysis and €4,612 per patient in the German analysis. Model results were sensitive to the cost of chemotherapy regimens and the prevalence of KRAS mutations in the population. Under most scenarios, using KRAS testing to select patients for EGFR inhibitor therapy saved $7,500–$12,400 per patient in the United States and €3,900–€9,600 per patient in Germany with equivalent clinical outcomes.
δ‐Mercaptolysine Assisted Ubiquitination
Authors: Kumar K. S. Ajish , Brik Ashraf 
Published: September 2011

AbstractThe field of chemical biology of ubiquitin is gaining significant interest in recent years due to the diversity and complexity of the ubiquitin signal in numerous biological functions in eukaryotes. The inability of biological methods to prepare ubiquitinated peptides and proteins with full control over the ubiquitination sites, types, and lengths of the ubiquitin chains is one of the main challenges in the ongoing efforts to fully understand the ubiquitin signal at the molecular level. This has been a major driving force for the development of chemical tools to complement biological methods in preparing ubiquitin bioconjugates for various biochemical and structural studies. This review deals with the recent advances in developing chemical methods for the synthesis of ubiquitinated peptides and proteins assisted by δ‐mercaptolysine, which enable isopeptide formation in a highly efficient and chemoselective manner.
Light‐guided lumpectomy: first clinical experience
Authors: Dayton Amanda , Soot Laurel , Wolf Ronald , Gougoutas‐Fox Christina , Prahl Scott 
Published: September 2011

AbstractDespite numerous advances, lumpectomy remains a challenging procedure. We report on the early use of light‐guided lumpectomy. Eight patients with non‐palpable breast cancer undergoing lumpectomy for biopsy‐proven and radiographically identifiable cancer were enrolled in the study. An optical wire was designed that incorporated a standard hook‐wire with an optical fiber. The optical wire was placed in the same manner as a standard hook‐wire. During light‐guided lumpectomy, an eye‐safe laser illuminated the optical wire and created a sphere of light surrounding the cancer. The light was visible at the beginning of each surgery and facilitated approaching the cancer without using the wire. Dissection around the sphere of light kept the wire tip within the surgical specimen. Three of eight initial surgical specimens had focally positive margins. Additional cavity shaves were performed during five lumpectomies and resulted in negative margins in seven of eight patients. Light‐guided lumpectomy is a minor change to breast conserving surgery that can be easily incorporated into clinical practice. Further investigation into the clinical benefit of light‐guided lumpectomy is warranted. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Assessment of decellularized porcine diaphragm conjugated with gold nanomaterials as a tissue scaffold for wound healing
Authors: Cozad Matthew J. , Bachman Sharon L. , Grant Sheila A. 
Published: September 2011

AbstractOne million Americans suffer from chronic wounds every year with diabetics and older populations representing the majority. Mechanisms that may be responsible for the reduced healing response in these patients include reduction in growth factors or vascularization and an increase in free radical levels. The focus of this study was to develop a biocompatible gold/porcine diaphragm scaffold capable of sustaining fibroblast attachment and proliferation which was measured using viability and dsDNA assays. The free radical scavenging properties, as measured by ROS assays, were also investigated as a mechanism for improving the wound environment. Results indicated 69–89% viability for gold nanoparticle (AuNP) scaffolds and 51–74% for gold nanorod (AuNR) scaffolds as compared to 100% for decellularized scaffolds and 77% for crosslinked scaffolds. All scaffolds exhibited good cell attachment while AuNP‐1X scaffolds showed the greatest cell proliferation with a 74% increase in dsDNA content from Day 3 to 7. AuNP‐2X and AuNP‐4X scaffolds generated higher levels of free radicals with AuNP‐4X generating over twice as much as decellularized scaffolds. This study suggests the capability for gold/porcine diaphragm scaffolds to enhance cell proliferation while the modification of free radical generation appears to be dependent on nanomaterial shape and concentration. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.