bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penggunaan Obat Antidiabetik Tunggal Dan Kombinasi Pada Penderita Diabetes Mellitus Tipe II Salah Satu Rumah Sakit Di Kota Bandung Periode Januari - Maret 2023
Authors: Safitri Maida 
Published: May 2024

Diabetes Mellitus merupakan suatu penyakit yang khas ditandai dengan adanya hiperglikemia atau kondisi dimana glukosa dalam darah meningkat atau melebihi batas normal. Untuk mengendalikan kadar glukosa dlam darah dapat diberikan pemberian obat antidiabetes oral maupun injeksi dapat diberikan secara tunggal maupun kombinasi. Penelitian ini bertujuan untuk melihat penggunaan antidiabetik terapi tunggal dan antidiabetik terapi kombinasi yang diberikan pada pasien diabetes. Penelitian ini merupakan penelitian deskriptif yang dilakukan pada 152 pasien penderita diabetes rawat jalan yang mendapatkan Obat Antidiabetik terapi tunggal dan kombinasi. Dari hasil penelitian persen rata-rata penggunaan obat antidiabetk tunggal yaitu 44,08 %, penggunaan 2 kombinasi obat antidiabetik sebanyak 55,92 % dibagi menjadi 2 kombinasi 34,87 %, penggunaan 3 kombinasi obat antidiabetik sebanyak 18,42 % dan kombinasi 4 obat antidiabetik sebanyak 2,63 %. Hasil ini menyimpulkan bahwa terapi kombinasi menunjukkan penggunaan yang lebih tinggi daripada terapi tunggal.
Manuscripts of the Treatise “Hadīqat Al-'Ārifīn” of Ishāq Khoja Bin Ismâ‘Īl Ata
Authors: Tuyakbayev Omir 
Published: May 2024

Reliability and validity of written sources is always critical in research. A key step in conducting thorough and accurate research is to find the most reliable and original versions of written sources. Researchers often rely on primary sources to ensure the highest level of credibility and accuracy in their work. Factors such as the preservation of the manuscript, the integrity of the text, the circumstances of the copying, and the environment in which the author and scribes worked and lived all contribute to determining the reliability and significance of a source. Paleographical and codicological data play a critical role in understanding the history and provenance of manuscripts, allowing researchers to assess their authenticity and importance in the context of their time and place. Analysis of such data can help shed light on research into these historical documents. Therefore, in the article we try to describe the paleographic and codicological features of the manuscripts of “Hadīqat al-’Ārifīn”, preserved in the book collections of Tashkent, Kokand, Kabul, Uppsala. Undoubtedly, this comparative analysis can provide valuable insight into the main dogmatists of the Yasavī Sufi school. By comparing different versions of the manuscript from different collections, researchers can analyze textual variations and stylistics that can shed light on the development and interpretation of Yasavī 's teachings within the Sufi tradition. The manuscript copies help to understand the evolution and transmission of Yasavī 's spiritual and philosophical ideas across different regions and time periods.
Keywords: Khoja Ahmad Yasavī, Ishāq Khoja, Ismā‘īl Ata, “Hadīqat al-’Ārifīn”, Turkistan Tashkent.
XV. Yüzyıl Ezoterik Anadolu Edvar Geleneğinin Musiki Nazariyatı ve Uygulamasına Sembolik Bir Bakış
Authors: Gündoğdu Artemur Orkun , Doğrusöz Dişiaçık Nilgün 
Published: May 2024

XV. yüzyıldaki Anadolu edvar geleneğinin teorik arka planı dönemin kozmos anlayışı olan makrokozmos ve mikrokozmos ile Neoplantoncu 4 aşamalı kozmos anlayışının yanı sıra kozmosun temel yapı taşlarını oluşturduğu düşünülen dört unsuru (toprak, su, hava ateş) sembolik olarak yansıtmaktadır. Bu yansıma nazariyatta makam yapılarının yapı taşı olan dört şube ve ilk veya “asıl” dört makam ile udun dört telinde ortaya çıkmaktadır. Usta ve çırak arasındaki pratiğe dayanan sözlü meşk geleneğin sembolik arka planına baktığımızda duyma yetisi ile dinlemenin öneminin öne çıktığı görülmektedir. Ayrıca makrokozmos ve mikrokozmos terimlerinin çeşitli kavramlar ve metaforlar yoluyla usta ve çırağı sembolize ettiği sonucu ortaya çıkmaktadır. Çalışmamızda ezoterik ekole mensup edvar yazarlarının teorik eserlerinden çıkarılan alıntılardaki sembolik anlamlar hermeneutik yöntemle yorumlanarak 15. yüzyıldaki Anadolu Edvar Geleneğinin arka planında yatan kozmos anlayışı, felsefe ve düşünce şeklinin bu ekolün metodoloji ve terminolojisine ne şekilde yansıdığının ortaya çıkarılması amaçlanmaktadır. Araştırmanın kapsamı 15. yüzyıl Osmanlı Anadolu’sundaki teori kaynakları ile bu yüzyılın Osmanlı/Anadolu dönemi ile sınırlandırılmıştır. Makalemizde yöntem olarak tarihsel kaynaklar üzerinden literatür taraması yapılması nedeniyle tarihsel müzikoloji disiplininden de yararlanılmaktadır. Literatür tarama ve kaynak belirleme de edvar yazarlarının nazari eserleri birincil kaynak olarak kullanılmış, ayrıca bu konularda yazılmış makale, döneme ait tarihsel bilgi içeren kitaplar ve tezlerden de faydalanılmıştır.
Anahtar Kelimeler: Makrokozmos/Mikrokozmos, Ezoterik, Meşk Geleneği, Usta/Çırak.
KEJADIAN DISMENOREA PRIMER PADA SISWI SMAN 5 BEKASI
Authors: Meilan Nessi 
Published: May 2024

Selama masa menstruasi kebanyakan remaja puteri sering mengalami ketidaknyamanan dalam bentuk kram perut, yaiut rasa sakit di bagian bawah perut yang kadang meluas ke pinggang, punggung atau paha. Bahkan ada yang merasa mual, muntah atau diare. Dismenorea adalah gangguan aliran darah haid atau nyeri haid. Lebih dari 50% perempuan mengalami dismenorea dan 15% diantaranya mengalami nyeri yang hebat. Biasanya dismenorea timbul pada masa remaja, yaitu sekitar 2-3 tahun setelah menstruasi pertama. Dismenorea merupakan permasalahan ginekologi utama yang paling sering dikeluhkan oleh remaja (French, 2008). Tujuan penelitian adalah untuk mengetahui faktor-faktor yang berhubungan dengan kejadian dismenorea pada siswi di SMAN 5 Bekasi tahun 2023. Jenis penelitian ini adalah cross sectional dengan besar sampel 66 responden. Penelitian ini dilakukan pada bulan April 2023. Data yang dikumpulkan menggunakan data primer dengan menggunakan kuesioner. Hasil penelitian ini menunjukkan adanya hubungan antara status gizi (nilai p 0,002), usia menarche (nilai p 0,048), lama menstruasi (nilai p 0,001), siklus menstruasi (nilai p 0,001) sedangkan aktivitas fisik (0,078) tidak ada hubungan dengan kejadian dismenorea. Hasil penelitian ini dapat dijadikan acuan agar responden dapat lebih aktif mencari informasi mengenai dismenorea sehingga menmbah ilmu pengetahuan dan wawasan mengenai kejadian dismenorea sehingga dapat melakukan tindakan pencegahan paling tepat untuk mengurangi rasa nyeri dismenorea saat menstruasi dan dampaknya dan remaja putri lebih siap dan tidak takut saat menghadapi menstruasi.
Kata kunci: Dismenorea, Karakteristik Individual, Aktivitas Fisik
Role of IT on the Effectiveness of Logistics and Supply Chain Management Systems in the Pharmaceutical Sector in Saudi Arabia Vision 2030
Authors: Junnaidi Maqsood Husain , Bhalla Pretty 
Published: May 2024

The main objective of this study is to evaluate how IT might improve the efficacy and efficiency of supply chain management and logistics systems in the pharmaceutical sector because the pharmaceutical industry is experiencing a transformation by the lofty objectives outlined by Saudi Arabia Vision 2030. The study was conducted using 150 executives working in the Saudi Arabian pharmaceutical industry's logistics and supply chain division. An open-ended survey questions were used to determine how IT technology affects pharmaceutical logistics and supply chain using non-probability sampling, logistics managers' LinkedIn accounts were selected for the sample, irrespective of the organization's size, location, or gender. SPSS statistical tools were used to analyse the data. It was found that the integration of IT tools and systems has emerged as a crucial enabler in this process. By harnessing the power of data analytics, IoT (Internet of Things), and automation, pharmaceutical companies can gain real-time insights into their supply chains. This, in turn, allows them to develop agile responses to changing market dynamics and customer expectations. Such strategic decisions, driven by IT, enable businesses to adapt quickly, reorganize their operations, and offer value-added services tailored to the specific needs of the market. Moreover, the creative application of IT solutions facilitates efficient inventory management, demand forecasting, and tracking of pharmaceutical products from manufacturing facilities to end consumers results also show that companies may simply increase the pace of the supply chain with the aid of innovative chances in major choices and judgments.
Organisational Dynamics and Local Government Autonomy in Nigeria. An Interrogation
Authors: Enejo Wada , Md Zan Zainal Bin , Khalid Mohamad Sukeri Bin 
Published: May 2024

This research paper attempt to investigate the critical relationship between the interplay of organizational dynamics and perceptions of local government autonomy in Nigeria political system. A comprehensive analysis of grade level distribution, departmental structure, and length of service among respondents forms the fulcrum of this study. The study unveils the diverse tapestry of influences shaping attitudes towards local government autonomy in Kogi State, Nigeria. Key findings highlight the pivotal role of mid-level professionals (grade levels 11 to 13), the varied priorities across departments, and the dynamic evolution of perceptions over time. Informed by these insights, our recommendations emphasized tailored strategies, leadership empowerment, and continuous engagement to foster an organizational environment that values and champions local government autonomy in Nigeria. This research contributes to a deeper understanding of the organizational intricacies influencing local governance and offers practical insights for policymakers and administrators seeking to enhance local government autonomy in Nigeria political systems.
A novel chaperone-effector-immunity system identified in uropathogenic Escherichia coli UMN026
Authors: Casiano González América , Pacheco Villanueva Arantxa , Castro-Alarcón Natividad , Méndez Julio , Oropeza Ricardo , Martínez-Santos Verónica I. 
Published: May 2024

Background
Urinary tract infections (UTIs) are very common worldwide. According to their symptomatology, these infections are classified as pyelonephritis, cystitis, or asymptomatic bacteriuria (AB). Approximately 75–95% of UTIs are caused by uropathogenic Escherichia coli (UPEC), which is an extraintestinal bacterium that possesses virulence factors for bacterial adherence and invasion in the urinary tract. In addition, UPEC possesses type 6 secretion systems (T6SS) as virulence mechanisms that can participate in bacterial competition and in bacterial pathogenicity. UPEC UMN026 carries three genes, namely, ECUMN_0231, ECUMN_0232, and ECUMN_0233, which encode three uncharacterized proteins related to the T6SS that are conserved in strains from phylogroups B2 and D and have been proposed as biomarkers of UTIs.

Aim
To analyze the frequency of the ECUMN_0231, ECUMN_0232, ECUMN_0233, and vgrG genes in UTI isolates, as well as their expression in Luria Bertani (LB) medium and urine; to determine whether these genes are related to UTI symptoms or bacterial competence and to identify functional domains on the putative proteins.

Methods
The frequency of the ECUMN and vgrG genes in 99 clinical isolates from UPEC was determined by endpoint PCR. The relationship between gene presence and UTI symptomatology was determined using the chi2 test, with p < 0.05 considered to indicate statistical significance. The expression of the three ECUMN genes and vgrG was analyzed by RT-PCR. The antibacterial activity of strain UMN026 was determined by bacterial competence assays. The identification of functional domains and the docking were performed using bioinformatic tools.

Results
The ECUMN genes are conserved in 33.3% of clinical isolates from patients with symptomatic and asymptomatic UTIs and have no relationship with UTI symptomatology. Of the ECUMN+ isolates, only five (15.15%, 5/33) had the three ECUMN and vgrG genes. These genes were expressed in LB broth and urine in UPEC UMN026 but not in all the clinical isolates. Strain UMN026 had antibacterial activity against UPEC clinical isolate 4014 (ECUMN−) and E. faecalis but not against isolate 4012 (ECUMN+). Bioinformatics analysis suggested that the ECUMN genes encode a chaperone/effector/immunity system.

Conclusions
The ECUMN genes are conserved in clinical isolates from symptomatic and asymptomatic patients and are not related to UTI symptoms. However, these genes encode a putative chaperone/effector/immunity system that seems to be involved in the antibacterial activity of strain UMN026.
Systematic evaluation and meta-analysis of the prognosis of down-staging human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma using cetuximab combined with radiotherapy instead of cisplatin combined with radiotherapy
Authors: Hu Qiong , Li Feng , Yang Kai 
Published: May 2024

Objective
To evaluate the efficacy and safety of cetuximab instead of cisplatin in combination with downstaging radiotherapy for papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (HPV+ OPSCC).

Design
Meta-analysis and systematic evaluation.

Data sources
The PubMed, Embase, Web of Science, and Cochrane library databases were searched up to June 8, 2023, as well as Clinicaltrials.gov Clinical Trials Registry, China Knowledge Network, Wanfang Data Knowledge Service Platform, and Wiprojournal.com.

Eligibility criteria for selecting studies
Randomized controlled trials reporting results of standard regimens of cetuximab + radiotherapy vs cisplatin + radiotherapy in treating HPV+ OPSCC were included. The primary outcomes of interest were overall survival (OS), progression-free survival (PFS), local regional failure rate (LRF), distant metastasis rate (DM), and adverse events (AE).

Data extraction and synthesis
Two reviewers independently extracted data and assessed the risk of bias of the included studies. The HR and its 95% CI were used as the effect analysis statistic for survival analysis, while the OR and its 95% CI were used as the effect analysis statistic for dichotomous variables. These statistics were extracted by the reviewers and aggregated using a fixed-effects model to synthesise the data.

Results
A total of 874 relevant papers were obtained from the initial search, and five papers that met the inclusion criteria were included; a total of 1,617 patients with HPV+ OPSCC were enrolled in these studies. Meta-analysis showed that OS and PFS were significantly shorter in the cetuximab + radiotherapy group of patients with HPV+ OPSCC compared with those in the conventional cisplatin + radiotherapy group (HR = 2.10, 95% CI [1.39–3.15], P = 0.0004; HR = 1.79, 95% CI [1.40–2.29], P < 0.0001); LRF and DM were significantly increased (HR = 2.22, 95% CI [1.58–3.11], P < 0.0001; HR = 1.66, 95% CI [1.07–2.58], P = 0.02), but there was no significant difference in overall grade 3 to 4, acute and late AE overall (OR = 0.86, 95% CI [0.65–1.13], P = 0.28).

Conclusions
Cisplatin + radiotherapy remains the standard treatment for HPV+ OPSCC. According to the 7th edition AJCC/UICC criteria, low-risk HPV+ OPSCC patients with a smoking history of ≤ 10 packs/year and non-pharyngeal tumors not involved in lymphatic metastasis had similar survival outcomes with cetuximab/cisplatin + radiotherapy. However, further clinical trials are necessary to determine whether cetuximab + radiotherapy can replace cisplatin + radiotherapy for degraded treatment in individuals who meet the aforementioned characteristics, particularly those with platinum drug allergies.

Prospero registration number
CRD42023445619.
Vaccine refusal in pregnant women in Kahramanmaraş: a community-based study from Türkiye
Authors: Okyay Ramazan Azim , Kaya Erhan , Erdoğan Ayşegül 
Published: May 2024

Background
The global health landscape is increasingly challenged by the rejection of childhood vaccines. This study investigates vaccination reservations and refusal among pregnant women.

Methods
A cross-sectional study was conducted in Kahramanmaraş, Türkiye, spanning January to March 2019, entailing face to face interviews with 938 pregnant women. The questionnaire collected sociodemographic data and probed vaccination attitudes. The decision to vaccinate the baby was treated as the dependent variable, analyzed alongside sociodemographic factors and other variables. Data underwent evaluation via descriptive analysis, the Chi-square test, and binary logistic regression.

Results
Participants had a mean age of 27.6 years. Among them 20 (2.1%) expressed intent to either abstain from or partially vaccinate their babies, with 70% citing apprehensions regarding potential vaccine-related harm. Statistical analysis unveiled that higher economic income, elevated parental education level, fewer than two children, reliance on the Internet for vaccination information, and a lack of trust in physicians significantly correlated with vaccine refusal among pregnant women (p < 0.05).

Conclusions
The study concludes that dissemination of vaccination information by the healthcare professionals, complemented by the enactment of pro-vaccine internet policies holds promise in shaping vaccination behavior.
THE SIGNIFICANCE OF KNOWLEDGE MANAGEMENT PROCESSES FOR BUSINESS SUSTIANABILITY: THE ROLE OF SUSTAINABILITY-ORIENTED PROJECTS
Authors: KLAUS-ROSIŃSKA Agata , WALECKA-JANKOWSKA Katarzyna , ZGRZYWA-ZIEMAK Anna 
Published: May 2024

The paper aims to investigate the correlation between knowledge management and business sustainability through sustainability-oriented projects. The role of projects in promoting sustainability is already recognized, with sustainability-oriented projects emerging as a pivotal mechanism for companies to actively contribute to sustainability goals. Theoretical arguments also suggest that the enhancement of knowledge management is crucial for the advancement of sustainable business. Still, assertions in both areas lack solid empirical verification. Simultaneously, there is a growing emphasis on exploring the connection between knowledge management and project management, as existing studies indicate that knowledge management enhances the efficiency and effectiveness of projects. However, the nexus between knowledge management, project management, and business sustainability remains largely unexplored. This study aims to address two questions: whether knowledge management has a positive effect on business sustainability, and whether it is mediated by sustainability-oriented projects. The research hypotheses are verified through a large-scale empirical study utilizing SEM.
Electromagnetic interference shielding of graphite/acrylonitrile butadiene styrene composites
Authors: Sachdev V. K. , Patel K. , Bhattacharya S. , Tandon R. P. 
Published: November 2010

AbstractDispersion of graphite within the acrylonitrile butadiene styrene matrix demonstrates enhanced electromagnetic interference shielding of composites through the use of tumble mixing technique. A shielding effectiveness of 60 dB with 15 wt % of graphite has been achieved. D shore hardness data revealed a little decrease in hardness of composites with rise in graphite content. DC conductivity measurements revealed a fairly low percolation threshold at 3 wt % of graphite. The conductivity exhibited by 15 wt % composite is 1.66 × 10−1 S/cm. These composites are fit for use as an effective and convenient EMI shielding material because of easy processing, better hardness, light weight, and, reasonable shielding efficiency. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Retinoic acid inhibits osteogenic differentiation of mouse embryonic palate mesenchymal cells
Authors: Chen Mu , Huang Hong‐Zhang , Wang Miao , Wang An‐Xun 
Published: November 2010

AbstractBACKGROUND: All‐trans‐retinoic acid (ATRA), a known teratogenic factor affecting the development of cleft palate, has been shown to adversely affect craniofacial development. In the present study, we evaluated the effects of ATRA on the osteo‐/adipogenic differentiation of mouse embryonic palate mesenchymal (MEPM) cells, which served as a valid model system for investigating the mechanisms regulating osteogenesis during palatogenesis. METHODS: MEPM cells were derived from gestational day 13 C57BL/6N mouse embryos and induced to differentiate in the presence or absence of ATRA in either osteogenic medium (OM) or control medium (CM). RESULTS: Alkaline phosphatase (ALP) activity assays, von Kossa staining, and RT‐PCR assays confirmed that MEPM cells underwent osteogenic differentiation when cultured in OM. Although ATRA induced ALP activity and lipid accumulation in MEPM cells, it failed to induce matrix mineralization and osteoblastic gene expression. BMPR‐IB and Smad5 mRNA levels increased significantly in cells cultured in OM and declined following treatment with ATRA, whereas the expression of the BMPR‐IA mRNA was up‐regulated by ATRA. CONCLUSIONS: In conclusion, our results suggested that ATRA and the BMP signaling pathway cooperate to inhibit osteogenesis and promote adipogenesis of MEPM cells. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc.
Outcomes after induction chemotherapy in patients with acute myeloid leukemia arising from myelodysplastic syndrome
Authors: Bello Celeste , Yu Daohai , Komrokji Rami S. , Zhu Weiwei , Wetzstein Gene A. , List Alan F. , Lancet Jeffrey E. 
Published: November 2010

AbstractBACKGROUND:Secondary acute myeloid leukemia (AML) from an antecedent myelodysplastic syndrome (MDS)/myeloproliferative neoplasm is associated with a poor prognosis. The authors evaluated predictive factors in patients with secondary AML treated with anthracycline‐based induction therapy.METHODS:This was a retrospective review of secondary AML patients treated with induction therapy. Age, International Prognostic Scoring System, Eastern Cooperative Oncology Group performance status, cytogenetics, duration of MDS/myeloproliferative neoplasm, and prior MDS/myeloproliferative neoplasm treatment were evaluated for their impact on complete response (CR), CR with low platelets, and overall survival (OS).RESULTS:The authors evaluated 61 secondary AML patients who received induction chemotherapy; 59% (36 patients) achieved CR/CR with low platelets (95% confidence interval [CI], 46%‐71%), and median OS was 6.5 (95% CI, 3.9‐8.1) months. Three factors were associated with lower CR/CR with low platelets and OS: poor risk cytogenetics, prior treatment with hypomethylating agents or lenalidomide, and longer time to transformation to AML. Of those treated with hypomethylating agents or lenalidomide, 32% achieved CR/CR with low platelets versus 78% in the group not treated with a hypomethylating agent or lenalidomide (odds ratio [OR], 0.13; 95% CI, 0.04‐0.42). Median OS for those treated with a hypomethylating agent or lenalidomide was 3.7 versus 10.5 months for those not treated with a hypomethylating agent or lenalidomide (P < .0001). The CR/CR with low platelets rate for those with intermediate risk cytogenetics was 70% versus 35% for those with poor risk (OR, 4.33; 95% CI, 1.38‐13.6). Those with poor risk cytogenetics had a median OS of 2.8 versus 7.5 months for those with intermediate risk (P = .01).CONCLUSIONS:Prior treatment with hypomethylating agents or lenalidomide, poor risk cytogenetics, and longer time to transformation to AML are independent negative predictive factors for response and OS in patients with secondary AML after induction therapy. Cancer 2011. © 2010 American Cancer Society.