bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two Minute Assay of Urinary Estriol in Pregnant Women
Authors: Miyakawa Isao , Koike Hiroyuki , Taniyama Kenichi , Mori Norimasa 
Published: August 2010

AbstractThe rapid assay of urinary E3 using latex agglutination inhibition reaction (LAIR, E3 slide method) was evaluated.Correlation was good between the E3 values assayed by the E3 slide method and the E3‐16‐glucuronide radioimmunoassay (r = 0.938) but only fair with the high performance liquid chromatography method (r = 0.851).The E3 slide method using LAIR for semi‐quantitative hormone assay takes only two minutes for each sample.Speed, simplicity and accuracy of the E3 slide method indicate its high clinical usefulness as a prospective large scale screening test of feto‐placental function.
Morphogenesis of Uterine Cervical Carcinoma
Authors: Hosokawa Tsutomu 
Published: August 2010

AbstractWe conducted a study on the morphogenesis of carcinoma in the cervix uteri from various angles, and drew the following conclusions.

Most of the epithelial changes in the cervix commonly called dysplasia and carcinoma in situ should not be defined as authentic cancers.
They are, however, different from mere benign changes and should be considered precancerous changes. It is most probable that carcinoma of the cervix develops in a “biphasic” or “polyphasic” manner, preceded by these changes.
It is not, however, necessarily justified to state that all cervical carcinomas develop through this same carcinogenic process, but it is probable that they develop through a “monophasic” process without passing through the “stage” of dysplasia or carcinoma in situ.
In other words, it can be said that even if such cervical carcinoma may present similar tissue patterns, their carcinogenic process may vary considerably.
Almost all carcinomas of the cervix, except for adenocarcinomas, originate in the squamo‐columnar junction, and they then initially spread into the region of the columnar epithelium.
Histogenetically, even squamous cell carcinomas are very likely to originate in the “reserve cells”, but the possibility of canceration in the regenerating squamous epithelium cannot be totally denied.
The Role of Diuretics in EPH Gestosis
Authors: Nayel Sayed A. , Latif Ibrahim L. Abdul , Kamel Salah M. , Elsorady Samy S. , Al Ali A. Abdel , Sayed Wadid S. 
Published: August 2010

AbstractForty five patients with moderate EPH gestosis were studied. Fifteen were treated with Hydrochlorothiazide and Methyl dopa, fifteen received Hydrochlorothiazide and Diazepam, and fifteen were treated with Diazepam. They were monitored clinically and biochemically for ten days. The findings were discussed.
Developmental Changes in Pituitary Function during the Prepubertal Period in Female Rats
Authors: Kawagoe Shinnosuke , Hiroi Masahiko 
Published: August 2010

AbstractTo observe the functional changes occurring in the pituitary gland during the prepubertal period in the female rat, pituitary responsiveness to synthetic Gn‐RH and changes in serum gonadotropins and estradiol were examined between 10–35 days of age. Serum LH, FSH and estradiol were elevated during the early infantile period, and then declined gradually as the animal approached maturity. Significant increases in serum LH levels were observed 15 minutes after intraperitoneal administration of synthetic Gn‐RH (100ng/100g BW) at all ages studied, although a slightly reduced LH release occurred in response to Gn‐RH between days 20–30. The pituitary FSH response to Gn‐RH was highest on day 10, followed by a general downward trend, and increased again on day 35. Gonadotropin responses to Gn‐RH were found to be almost completely suppressed in the rats ovariectomized at 10 postnatal days. However, pretreatment with estradiol benzoate (EB) following ovariectomy produced a significant increase of LH and FSH release in response to Gn‐RH. Progesterone, administered in combination with EB, showed no further influence on the sensitivity of the pituitary to Gn‐RH. These results suggest that ovarian steroids, especially estrogen, may play an important role in the maturing processes of the pituitary function during the prepubertal phase.
Estrogen and Progestogen Receptor Levels in Different Types of Mid‐Secretory Endometrium
Authors: Tamaya Teruhiko , Murakami Toshiki , Ohono Yousuke , Yamada Toshio , Wada Keisuke , Okada Hiroji 
Published: August 2010

AbstractHuman endometrial estrogen and progestogen receptor levels in the mid‐secretory phase were determined in various types of endometrium to contribute to a better understanding of luteal insufficiency. The concentrations of both total estrogen and progestogen receptor sites (both cytosol and nuclear; both occupied and unoccupied) decreased in the out‐of‐phase endometrium (p<0.025) and tended to decrease in the hypoplastic uterine endometrium, compared with those of the in‐phase endometrium. However, serum steroid levels in both groups showed no difference. The findings suggest that being out of phase reflects the indigenously reduced number of endometrial cellular receptors. This hypothesis would seem to aid our understanding of the hypoplastic uterus. Clomiphene treatment during the luteal phase changed the out‐of‐phase endometrium to in‐phase endometrium in some cases (19 out of 36); in these cases, the endometrial steroid receptor levels reached the levels attained in the in‐phase endometrium and the gonadotropin secretion was stimulated to greater than the controls, resulting in increased steroid synthesis.
Identification of Affected Sites in Fetal Gastroduodenal Obstructions by Real‐time Ultrasonic Tomography
Authors: Nabekura Junichi , Shin Takeshi , Koyanagi Takashi , Nakano Hitoo 
Published: August 2010

AbstractIn four fetuses with gastroduodenal obstructions, different types of lesions were diagnosed prenatally by real‐time ultrasonic tomography. Surgery in the early neonatal period confirmed these findings. The sites of obstruction corresponded to the anatomical configuration of the gastroduodenal area.Diagnostic criteria to identify individual lesions are proposed for use in a clinical setting.
Prenatal Diagnosis of Ebstein's Anomaly
Authors: Hara Kenji , Koyanagi Takashi , Nakano Hitoo 
Published: August 2010

AbstractIn utero real‐time ultrasonic tomography revealed malattachment of the tricuspid valve in two cases at 33 weeks of gestation. Enlargement of the right ventricle and atrium and a decrease in thickness of the right ventricular wall were also observed in one fetus while a small ventricle and enlargement of the right atrium were seen in the second fetus. This is the first documentation of Ebstein's anomaly diagnosed in utero.
Sixteen Years Experience in Treatment and Follow‐up of Patients with Trophoblastic Diseases*
Authors: Mochizuki Matsuto , Ashitaka Yoshihiko , Maruo Takeshi , Masuko Kazuhisa , Harada Akira , Chough Sou‐Yong 
Published: August 2010

AbstractFrom 1967 to 1982, 496 women with trophoblastic diseases received treatment and close follow‐up thereafter at Kobe University Hospital. Of the 306 women who had hydatidiform mole evacuated at our hospital, invasive mole was followed by sequelae in 27 (9.1%), persistent trophoblastic disease (PTD) in 24 (8.1%), and choriocarcinoma in 2 (0.68%). Of the 496, 31 had choriocarcinoma with a survival rate of 51.6% as compared to a survival rate of 95.5% in the remaining patients with 115 invasive moles and with 97 PTDs. All 7 patients with non‐metastatic choriocarcinoma were cured, while 14 (58.3%) out of 24 with metastatic choriocarcinoma died. The poor prognosis in choriocarcinoma resulted from metastases to multiple organs. Of the patients with malignant sequelae, 89.7% (218/243) had hydatidiform mole in the antecedent pregnancy, indicating that it is extremely important to follow‐up patients closely after molar evacuation. The hCG excretion pattern is the most specific prognostic indicator. For routine hCG determination it is convenient to set up the following check points: 1,000 IU/1 at the 4th week, 100 IU/1 at the 6th week and 30 IU/1 at the 8th week following molar evacuation. There was no recurrence of invasive mole and PTD after the diagnosis of remission (less than 5–10 mlU/ml in sera for more than 3 weeks) confirmed by hCG‐beta RIA. However, in one case of choriocarcinoma there was recurrence even after the diagnosis of remission determined by hCG‐beta CTP assay (less than 0.5–1.1 IU/day in urine for more than 3 weeks). Initial chemotherapy given to patients with malignant sequelae should be considered “trial chemotherapy” instead of “primary chemotherapy”, the latter term being reserved for successful initial treatment.
Preoperative Diagnosis of Malignant Ovarian Tumors by Measuring Serum Fibrin Degradation Products
Authors: Kaibara Manabu , Marumoto Yuriko , Kobayashi Takuro 
Published: August 2010

AbstractSerum levels of fibrin degradation products (FDP) were determined using an FDP slide test (a latex agglutination reaction method) in 20 normal control women and 67 preoperative patients with ovarian tumors. In the control women the FDP levels were 2.5 μg/ml or lower. In the 14 patients with ovarian retention cysts including endometrial cysts the FDP levels were normal (2.5 μg/ml or lower). In the 40 patients with benign ovarian neoplasmas, 37 (93%) showed normal FDP levels. On the contrary, in the 12 patients with malignant ovarian tumors, abnormally high levels of FDP were observed in 9 cases (75%). These observations revealed that the preoperative measurements of serum FDP contributed to the preoperative diagnosis of malignant ovarian tumors.
Ethnic Birth Patterns and Fetal Outcome in Auckland and New Zealand in the 1970's and Their Medico‐ social Implications: Part I Birth Patterns, Fetal Infant Outcome
Authors: Hutchison C .P. T. 
Published: August 2010

Abstract1973, 1976, 1977 and 1978 are the only years that national data is available that measure fetal outcome and birth statistics for Maoris, Pacific Islanders, and others.Pacific Islanders have the highest stillbirth rate but overall the lowest infant mortality. Maoris have the highest infant mortality and the highest proportion of lower birth weight infants.In 1976, Maoris formed 8.6% of the New Zealand population but produced 12% of the births. Pacific Islanders formed 2% of the population and produced 5.7% of the births. European birth rates averaged 16.3/1000, Maori birth rates averaged 24.7/1000, while the Pacific Islanders rate was 57.1/1000.Auckland now contains the largest Polynesian population in the world. It appears that Maori and possibly Pacific Islanders are disadvantaged in terms of employment, education, income, health and legal offending.It is postulated that ‘cycles of disadvantage’ could be broken by preventive education and health incentives from an early age.
A Critical Evaluation of Subfertility Investigations
Authors: Ho Pak‐Chung , Tang Grace W. K. , Ma Ho‐Kei 
Published: August 2010

AbstractHo PC, Tang GWK and Ma HK (Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong). A critical evaluation of subfertility investigations.The investigations done for the infertile couple attending the Subfertility Clinic of the Hong Kong University Gynaecological Unit from 1975 to 1979 were reviewed. The Rubin's tubal insufflation test has been replaced partly by laparoscopy which was found to be the more accurate and informative method of tubal assessment. Basal body temperature charts were not accurate in the diagnosis of luteal phase defect. In 22% of patients, endometrial biopsy specimens were inadequate or could not be obtained because of technical difficulty and failed to give the information required. A seminal count of less than 20 million per ml was found to be indicative of decreased fertility of the male partner. Despite the increase in the number and varieties of investigations, there was little improvement in the overall pregnancy rate.
Cervical Mucus Glucose and Its Relation to Sperm Penetrability in the Periovulatory Phase in Infertile Women
Authors: Tripathi Reva , Sharma Usha , Shah Cherry , Mehrotra M. L. 
Published: August 2010

AbstractCervical mucus glucose levels have been estimated during the periovulatory phase. They have been found to be significantly lower in infertile women than in those of known fertility. Sperm penetration was also studied in relation to the cervical mucus glucose concentration and it has been found to be directly proportional to the glucose content.
Ultrastructural Observation of the Placenta in Prolonged Pregnancy
Authors: Ito Haruhide , Tanaka Tadao , Watanabe Hiroshi , Ito Keiko 
Published: August 2010

AbstractThe placenta in prolonged pregnancy was observed under the electron microscope.Placentae were collected from 12 cases in the 43rd to the 45th gestational week. In these placentae, abnormal findings of the villous stroma, especially the vessels and the trophoblast, were observed, in addition to the changes normally observed with aging.Most of these changes appear to be caused by uteroplacental ischemia, and a decrease in functional activity of the placenta in prolonged pregnancy is suggested morphologically.
Effect of γ‐Oryzanol on Serum Lipid Peroxide Level and Clinical Symptoms of Patients with Climacteric Disturbances
Authors: Ishihara Minoru 
Published: August 2010

AbstractThe effect of γ‐Oryzanol, ferulic acid esters obtained from rice oil, on climacteric disturbances was studied with special reference to lipid peroxide levels in the sera of patient. 300 mg of γ‐Oryzanol was administered daily to each patient for 4 to 8 weeks. In 85% of 40 cases the effect on the climacteric disturbance was judged by the Kupperman method to be significant. In patients with climacteric disturbances, serum lipid peroxide levels were high, but were reduced significantly after administration of γ‐Oryzanol. By its administration, total cholesterol, triglyceride and HDL‐cholesterol were improved in cases with hyperlipidemia (TC<220 mg/dl, TG<140 mg/dl, HDL‐chol.>;45 mg/dl). The atherogenic index was also considerably reduced. No side effects and no particular changes in functional tests were observed.
The Effect of Ginseng on Serum Total Cholesterol, HDL‐Cholesterol and Triglyceride Levels in Postmenopausal Women
Authors: Punnonen Reijo , Lukola Altti 
Published: August 2010

AbstractThe effect of ginseng therapy on serum lipids was investigated in 15 postmenopausal women. The duration of the treatment was twelve weeks and the daily dose of the radix ginseng was 250 mg twice a day. No significant changes were found during ginseng therapy in the serum cholesterol, HDL‐cholesterol and triglyceride levels.
Perinatal Outcome of Induced Labour
Authors: Arulkumaran S. , Gibb D. M. F. , Heng S. H. , Ratnam S. S. 
Published: August 2010

SummaryFrom 1st January 1982 to 31st March 1983, 1057 consecutive cases of induced labour were studied in the University Unit, Kandang Kerbau Hospital, Singapore. The rate of induction was 9.8% and the method was artificial rupture of membranes and oxytocin titration. 559 (52.9%) were primigravidae and 498 (47.1%) were multigravidae. The leading indications were static weight or weight loss at term 356 cases (33.6%), pre‐eclampsia 240 cases (22.7%), and prolonged pregnancy 100 cases (9.5%).129 (12.3%) had amniotic fluid abnormalities at artificial rupture of membranes. 944 (89.3%) were monitored by cardio‐tocography during labour. 12.1% had suspicious fetal heart rate traces and 8.1% abnormal traces. Fetal blood sampling was used in 3% of monitored cases. There was no incidence of cord prolapse intrauterine infection, or of placental abruption.There were no intrapartum deaths and three early neonatal deaths, one of which had unsuspected lethal congenital malformations. Fifty neonates (4.7%) were admitted to the special care baby unit (SCBU), thirteen (1.2%) having required intubation. In a control group of spontaneous labours 4.6% of low risk and 8.5% of high risk normally formed neonates over 2500 grams birth weight were admitted to the SCBU. The mean Apgar score in the study group was 8.6 at 1 minute and 9.8 at 5 minutes.The emergency caesarean section rate in induced labour was 16.5% compared with 6.1% in spontaneous labour. Failed induction of labour was the indication in 42.0% of cases followed by fetal distress in 33.3% of cases.Whilst the perinatal outcome of induced labour was good, the caesarean section rate was high especially in primigravidae. More objective analysis of the degree of fetal compromise before induction of labour should reduce the induction rate and the caesarean section rate without detriment to perinatal outcome.
Neonatal Hyperbilirubinemia in Oxytocin Augmented Labour
Authors: Hamad Salah A. , El‐Domiaty Bothaina A. , Philips Dalai A. , Nayel Sayed A. 
Published: August 2010

AbstractThe relationship between the intrapartum use of oxytocin and neonatal hyperbilirubinemia was investigated. Twenty full‐term infants born after spontaneous vaginal labour and twenty term infants born after an accelerated labour by oxytocin, were included in the study. The results showed that there is a definite dose related association between the intrapartum administration of oxytocin and the subsequent development of neonatal hyperbilirubinemia. The possible factors entailed in the development of this oxytocin related hyperbilirubinemia are discussed.
Spontaneous Rupture of Utero‐Ovarian Vein in the 33rd Week of Pregnanc‐
Authors: Takahashi Toru , Kikuchi Saburo 
Published: August 2010

Summary

A case of massive intraperitoneal hemorrhage resulting from rupture of the utero‐ovarian vein in the 33rd week of pregnanc‐ is presented.
The survival of both the mother and her infant was attributed to the earl‐ surgical intervention.
The diagnosis of utero‐ovarian vein rupture can be made onl‐ if one keeps in mind the possibilit‐ of its occurrence.
CA125 Production by Gynecologic Tumors in Vitro and its Modulation Induced by Dibutyl Cyclic Adenosine Monophosphate
Authors: Ishiwata Isamu , Ishiwata Chieko , Nozawa Shiro , Ishikawa Hiroshi 
Published: August 2010

AbstractCA125, an antigenic determinant in conditioned media (Ham's F‐12 supplemented with 15% fetal calf serum) of gynecologic neoplasms was detected by immunoradiometric assay using a monoclonal antibody (CA125 RIA KIT). Seven out of 9 ovarian malignant tumor cell lines and 6 out of 8 endometrial carcinoma cell lines produced ≥ 8 U/ml of CA125, while CA125 values in the conditioned media of 4 uterine cervical epidermoid carcinoma cell lines, 3 uterine sarcoma cell lines and normal cells were < 8 U/ml. Human ovarian carcinoma cell lines (HUOA, HTOA, HMOA and HYOA) and endometrial carcinoma cell line (HHUA) were cultured in HB101TM serum‐free medium and their proliferation and CA125 producing activity were studied. HMOA and HTOA cells produced large amounts of CA125, while HUOA, HYOA and HHUA produced small amounts of CA125 in the conditioned media. Dibutyl cyclic adenosine monophosphate suppressed their proliferation and increased CA125 levels not only in the very CA125‐productive cultures, but also in the less CA125‐productive cultures.
Early Onset Neonatal Group B Streptococcal Infection in Hong Kong
Authors: Chan S. H. , Lau S. P. , Fok T. F. , Liang S. T. 
Published: August 2010

AbstractThe attack rates of early onset streptococcal sepsis in Chinese neonates was found to be 0.58 cases per 1000 among 19118 live births at Tsan Yuk Maternity Hospital. This low attack rate is probably due to a low GBS genital carriage rate and the absence of serotype II GBS in local pregnant women. Risk factors found to be associated with neonatal diseases are maternal fever, prolonged rupture of membrane, gestational diabetes mellitus. Prematurity and multiple pregnancy, which are recognised risk factors in Caucasian populations, are not found to have an important influence on the development of neonatal sepsis in Chinese. The clinical features of affected neonates in our series do not differ from the classical description. Mortality and morbidity are associated with neonatal meningitis exclusively.
Antenatal Diagnosis of Fetus in Fetu
Authors: Sada Ikuko , Shiratori Hideyo , Nakamura Yukio 
Published: August 2010

AbstractThe ability to make an antenatal diagnosis of fetus in fetu by ultrasonography and fetography is described. The mother had developed hydramnios at 29 weeks of gestation, and ultrasonography showed two huge tumors in the abdomen and gluteal region. A fetography revealed distension at the abdominal and gluteal region, and displacement of the colon anteriad by the retroperitoneal mass. At 34 weeks of gestation, a female infant weighing about 3500 g was delivered by cesarean section. Subsequently, a laparotomy was performed, revealing a huge spheroidal retroperitoneal mass joined to the sacrococcygeal mass. Confirmatory pathological examination showed a thick capsule resembling a scalp and a poorly formed embryonic mass containing vertebral, long bones, and intestine. Four months postoperatively, the autosite was in good health.
Pattern Change of Late Deceleration Throughout Pregnancy: A Case Report
Authors: Kawarabayashi Tatsuhiko , Kishikawa Tadao , Shono Hideaki , Sugimori Hajime 
Published: August 2010

AbstractA typical late deceleration was observed in a CTG monitoring of a woman in her 23rd week of pregnancy, with preterm labor. The pattern of the deceleration gradually changed to that of early deceleration, and finally disappeared as the pregnancy progressed. Fetal development was normal throughout the pregnancy, and a viable infant was delivered. The significance of late deceleration occurring at mid‐term pregnancy may differ from that occurring in late pregnancy, and may reflect physiological development of the fetus at the time.
Metastatic Gestational Trophoblastic Disease: A Study of Institutional and Non‐Institutional Cases at the National Hospital for Women Philippines
Authors: Panlilio Herminia Baja , Sanchez Fernando S. 
Published: August 2010

AbstractThis study aims to find out the results of our management of metastatic trophoblastic disease as they occurred in our hospital from 1966 to 1975. Only those that originated from hydatidiform mole were selected (49 cases). Those that came from hydatidiform mole and were admitted as such were classified as institutional cases while those that were handled outside the institution were classified as non‐institutional cases. Results showed that in institutional cases, mortality was 40% while in the non‐institutional group, mortality was 65.5% with an average of 55.1% for both groups.Choriocarcinoma with metastasis gave the highest mortality rate. Analysis of the cases showed that the main cause of mortality was hemorrhage from the uterine or metastatic lesion in the genitals. The most common site of metastasis was the lungs.The significant factors determining the prognosis were the stage of the disease at initial presentation, and the quality of follow‐ups, aside from the inherent characteristic behaviour of the trophoblast.
Studies on Diagnostic Criteria for Gestational Diabetes Mellitus by 75 g Glucose Tolerance Test
Authors: Hamada Teiji , Tetsuou Masahiro , Yoshimatsu Kiyotaka , Amagase Noriaki , Ooshima Toshiyuki , Kubo Norio 
Published: August 2010

AbstractThe glucose tolerance test (GTT) was performed on 722 pregnant women to evaluate the diagnostic criteria for gestational diabetes mellitus (GDM) by the 75 g GTT. The upper limits of the normal levels of plasma glucose were defined as 100 mg/dl, 180 mg/dl and 150 mg/dl at fasting and 1 and 2 hours after glucose loads, respectively. The individuals were termed GDM if 2 or more values were greater than the upper limit at each time point. The incidence of GDM based on our criteria was 3.3% of all subjects. The insulinogenic indices were low and hemoglobin Ale levels were high in the women with GDM. The incidence of fetal and neonatal complications born to mothers with GDM was high. The patients diagnosed as GDM in the present study appeared to show certain differences in clinical features compared to pregnant women with normal glucose tolerance.