bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing quantity and spatial patterns of greenspaces in Chinese universities for enhancing sustainable development
Authors: Yuan Xinqun , Li Xiyu , Yu Le , Liu Tao , Cao Yue 
Published: June 2024

AbstractGreenspaces on university campuses have gained recognition for their multifaceted impact on the physical, social, emotional and intellectual well‐being of students. The allocation of resources towards the development and maintenance of greenspaces is regarded as a strategy in the pursuit of sustainable development goals. However, the research on greenspaces within higher education has been inadequate. This study conducts an assessment of greenspaces within 2556 Chinese universities using remote sensing and geospatial technology, analysing the disparities in their distribution and exploring the spatial patterns and driving factors on a national scale. A national university greenspace database is obtained. Unexpectedly, the study finds that greenspace area and proportion within Chinese universities are relatively low in comparison to the greenspace areas outside the campus and of the city. There is heterogeneity and a decreasing trend in university greenspace. Compared to university faculty and off‐campus population, university students have the lowest per capita greenspace area. Of concern is the significant issue of greenspace inequality. Our research suggests that the inequality in greenspace provision for university students can be explained by factors of economic development, educational investments and provincial greenspace supply. This study provides an in‐depth analysis of the state of greenspaces in Chinese universities and calls for interdisciplinary and interdepartmental cooperation to address issues of greenspace inequality and campus greening, ensuring the sustainability and livability of urban areas and university campuses.
Replacing pullulan with sodium caseinate to enhance the properties of pullulan nanofibres
Authors: Dabora Suaad , Jiang Bo , Mahdi Amer Ali , Ali Khubaib , Tahir Assam Bin 
Published: June 2024

SummaryThis study investigated the feasibility of using sodium caseinate (NaCAS) to improve the properties of electrospun pullulan (PUL) nanofibres. Replacing PUL with 50% NaCAS [50:50(PUL: NaCAS)] resulted in appropriate viscosity for fibre formation (968.93 mPa.s), increased solution conductivity (1682.50 μS cm−1), decreased surface tension (59.55 mN m−1), which led to forming beadles' fibres with the smallest diameter (141.21 nm), highest water contact angles (117°), and highest thermal stability (24.03% residue weight at 600 °C). X‐ray diffraction and Fourier‐transform infrared spectroscopy analyses provided insights into nanofibres' structural and chemical properties and indicated successful blending of the PUL and NaCAS. Results indicated that replacing PUL with 50% NaCAS improved fibre properties. These findings contribute to the development of novel biopolymer‐based nanofibres with potential applications in various industries, including food and bioencapsulation.
Effects of solvent extracts prepared from the cultivars and plant parts of Centella asiatica cultivated in Korea on macrophage activation
Authors: Shin Hyun Young , Jeong Eun‐Jin , Kim Hoon , Kim Yeon Suk , Son Seung‐U , Shin Kwang‐Soon , Lee Kyung‐Haeng , Bae Yun‐Jung , Yu Kwang‐Won 
Published: June 2024

SummaryPrevious studies demonstrated the interrelationship between antioxidant activity and solvent extracts prepared according to cultivars and plant parts of Centella asiatica (CA) cultivated in Korea. In this study, the macrophage‐stimulating activity of solvent extracts was assayed, and we analysed the characteristics of the active fractions of these extracts and the mechanisms underlying the macrophage‐stimulating activity of these fractions. Treatment of macrophages with cold water (CW) extracts (GO‐L‐CW) prepared from the leaves (L) of the ‘GOOD’ (GO) cultivar significantly increased the secretion of immunostimulatory factors. Specifically, the high molecular weight (HMW) fraction (GO‐L‐CW‐HMW) isolated from GO‐L‐CW potently activated the secretion of immunostimulatory factors and increased the mRNA levels of genes encoding these factors or involved in the production of these factors. In addition, GO‐L‐CW‐HMW triggered the phosphorylation of ERK and p38 of MAPK along with p65 and IκBα of the NF‐κB family in the intracellular signalling pathway. The GO‐L‐CW‐HMW was identified as a complex polysaccharide with a molecular weight of 93–129 kDa. In conclusion, polysaccharides present in GO‐L‐CW suggest the possibility of application as a new immunostimulating material.
Effects of a constructed response retest strategy on faking, test perceptions, and criterion‐related validity of situational judgment tests
Authors: Xi Liyan , Weng Qingxiong , Corstjens Jan , Wang Xiujuan , Chen Lixin 
Published: June 2024

AbstractThis research proposes a faking‐mitigation strategy for situational judgment tests (SJTs), referred to as the constructed response retest (CR‐retest). The CR‐retest strategy involves presenting SJT items in a constructed response format first, followed by equivalent closed‐ended items with the same situation description. Two field experiments (N1 = 733, N2 = 273) were conducted to investigate the effects of this strategy and contrast it with a commonly used pretest warning message. Study 1 revealed that the CR‐retest strategy was more effective than the warning message in reducing score inflation and improving criterion‐related validity. Study 2 delved deeper by investigating the effects of the CR‐retest strategy on applicant reactions in a 2 (with or without CR‐retest strategy) × 2 (warning or control message) between‐subjects design. The results showed that applicants reported positive fairness perceptions on SJT items with the CR‐retest strategy. The CR‐retest strategy was effective in reducing faking by evoking threat perceptions, whereas the warning message heightened threat and fear. Combining two strategies further decreased faking without undermining fairness perceptions. Overall, our results indicate that the CR‐retest strategy could be a valuable method to mitigate faking in real‐life selection settings.
Polish nurses in Norway: Migration for “normal” work–life balance
Authors: Pawlak Marek , Seeberg Marie Louise 
Published: June 2024

AbstractThis paper expands and enriches existing knowledge on the work–life balance of migrant workers by exploring the experiences of Polish nurses in Norway. Previous studies predominantly highlight the obstacles faced by migrant workers, such as discrimination, low status and poor working conditions, in achieving work–life balance. Based on ethnographic interviews with 15 Polish nurses working in Norwegian hospitals and nursing homes, our main finding is that these nurses achieved work–life balance through migration. This finding should be viewed in light of their previous experiences in Poland, a precarious state where work–life balance is largely absent, and the apparent insignificance of discrimination in the host country for this group of migrants. The study highlights work–life balance as a cultural process of normalization, constantly negotiated and symbolizing “the West”. Furthermore, it brings attention to the role of class, ethnicity and national contexts in the work–life balance of migrant women.
Do binge drinking adolescents have a greater number of traumatised teeth? A longitudinal study with 12‐year‐olds in Brazil
Authors: Paiva Haroldo Neves de , Guimarães Mariana Oliveira , Filho Paulo Messias de Oliveira , Ferreira Raquel Conceição , Zarzar Patrícia Maria , Paiva Paula Cristina Pelli 
Published: June 2024

AbstractBackgroundBinge drinking has been linked to traumatic dental injury (TDI). Once drunk, adolescents are more prone to accidents, which may result in orofacial injury.AimThis study evaluated the possible association of binge drinking with a number of traumatised teeth in a population of 12‐year‐old Brazilian adolescents in 2013 and 2015.DesignThis study was longitudinal, carried out with 588 adolescents at two moments, 2013 and 2015. TDI, overjet and lip protection were assessed by calibrated examiners. Binge drinking data were collected through the Alcohol Use Disorders Identification Test. Sociodemographic indicators were obtained through a questionnaire answered by the parents/guardians. The Poisson regression model with a random effects intercept was estimated.ResultsA higher prevalence of traumatised teeth was observed among adolescents who binge drink (IRR = 1.37; 95% CI: 1.05–1.80; p < .05). The prevalence was also significantly higher among adolescents in this age range with a ≥ 3‐mm overjet and those with inadequate lip protection (IRR = 1.99; 95% CI: 1.44–2.76; p < .001 and IRR = 3.41; 95% CI: 2.57–4.53; p < .001, respectively).ConclusionA greater number of traumatised teeth were found among adolescents who reported binge drinking and had severe overjet and inadequate lip coverage.
Freedom from fear and subjective well‐being: Does personal security affect life satisfaction?
Authors: Chakma Anurug 
Published: June 2024

AbstractWhat factors contribute to the life satisfaction of indigenous communities residing in the Chittagong Hill Tracts (CHT) in south‐eastern Bangladesh? This research delves into this question by examining the impacts of personal security, a key component of human security, on life satisfaction. A survey was undertaken in the CHT, collecting self‐reported data on personal security and life satisfaction from 384 indigenous respondents. Employing both ordinary least squares regressions and Tobit regressions, this study reveals a discernible and statistically significant negative association between personal insecurity and life satisfaction. The findings of this investigation underscore the importance of addressing personal security threats to enhance the well‐being of indigenous populations in the CHT. Policymakers and stakeholders can foster an environment where indigenous communities can survive, thrive and flourish by prioritizing measures to ensure freedom from fear.
Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1/endoplasmic reticulum stress pathway
Authors: Wang Xiaohui , Tao Junli , Zhou Jianping , Shu Yi , Xu Jie 
Published: June 2024

AbstractExcessive load on the temporomandibular joint (TMJ) is a significant factor in the development of TMJ osteoarthritis, contributing to cartilage degeneration. The specific mechanism through which excessive load induces TMJ osteoarthritis is not fully understood; however, mechanically‐activated (MA) ion channels play a crucial role. Among these channels, Piezo1 has been identified as a mediator of chondrocyte catabolic responses and is markedly increased in osteoarthritis. Our observations indicate that, under excessive load conditions, endoplasmic reticulum stress in chondrocytes results in apoptosis of the TMJ chondrocytes. Importantly, using the Piezo1 inhibitor GsMTx4 demonstrates its potential to alleviate this condition. Furthermore, Piezo1 mediates endoplasmic reticulum stress in chondrocytes by inducing calcium ion influx. Our research substantiates the role of Piezo1 as a pivotal ion channel in mediating chondrocyte overload. It elucidates the link between excessive load, cell apoptosis, and calcium ion influx through Piezo1. The findings underscore Piezo1 as a key player in the pathogenesis of TMJ osteoarthritis, shedding light on potential therapeutic interventions for this condition.
SIAH2 suppresses c‐JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma
Authors: Hu Qinghe , Liu Zhiyi , Liu Yao , Qiu Jie , Zhang Xue , Sun Jun , Zhang Bin , Shi Hengliang 
Published: June 2024

AbstractAs an important protein encoded by hepatitis B virus (HBV), HBV X protein (HBx) plays an important role in the development of hepatocellular carcinoma (HCC). It has been shown that seven in absentia homologue 1 (SIAH1) could regulates the degradation of HBx through the ubiquitin‐proteasome pathway. However, as a member of SIAH family, the regulatory effects of SIAH2 on HBx remain unclear. In this study, we first confirmed that SIAH2 could reduce the protein levels of HBx depending on its E3 ligase activity. Moreover, SIAH2 interacted with HBx and induced its K48‐linked polyubiquitination and proteasomal degradation. Furthermore, we provided evidence that SIAH2 inhibits HBx‐associated HCC cells proliferation by regulating HBx. In conclusion, our study identified a novel role for SIAH2 in promoting HBx degradation and SIAH2 exerts an inhibitory effect in the proliferation of HBx‐associated HCC through inducing the degradation of HBx. Our study provides a new idea for the targeted degradation of HBx and may have great huge significance into providing novel evidence for the targeted therapy of HBV‐infected HCC.
Introduction and temporospatial tracing of piscine orthoreovirus‐1 (PRV‐1) in Norwegian farmed Atlantic salmon (Salmo salar) after local fallowing
Authors: Vatne Nina A. , Wessel Øystein , Trengereid Henrik , Haugsland Signe , Rimstad Espen , Stormoen Marit 
Published: June 2024

AbstractPiscine orthoreovirus‐1 (PRV‐1) is a prevalent agent in Atlantic salmon (Salmo salar) and the causative agent of heart and skeletal muscle inflammation (HSMI), an important disease in farmed Atlantic salmon. Investigations into the introduction and dissemination routes of PRV‐1 in a field setting have been limited. This study aimed to better understand PRV‐1 infections and HSMI‐associated mortality under field conditions. We tracked introduction and spread of PRV‐1 over one production cycle in a geographically isolated region in Norwegian aquaculture. From five sites, a total of 32 virus isolates were sequenced and genogrouped. The results indicated multiple introductions of PRV‐1 to the area, but also revealed a high level of genetic homogeneity among the virus variants. The variants differed from that of the previous production cycle at two out of three sites investigated, suggesting that synchronized fallowing can be a useful tool for preventing dissemination of PRV‐1 between generations of fish. Exposure to PRV‐1 at the freshwater stage was identified as a potential source of introduction. A low level of HSMI‐associated mortality was observed at all sites, with the onset of mortality showing some variation across PRV‐1 genogroups. However, the study highlighted the complexity of associating viral genogroups with mortality in a field setting. Overall, this study contributes valuable insights into PRV‐1 dynamics in a real‐world aquaculture setting, offering potential strategies for disease management and prevention.
Taking John Schulenberg's “long view” on successful transitions to adulthood: Associations with adult substance use
Authors: Rothenberg W. Andrew , Godwin Jennifer W. , Copeland William E. , Shanahan Lilly , Gaydosh Lauren , Gutin Iliya , Coltrane Asha 
Published: June 2024

AbstractCan positive transitions into young adulthood at age 25 prevent problematic substance use at age 31, even in the context of childhood adverse family environments, conduct problems, and adolescent substance use? We lean on John Schulenberg's developmental framework to examine this question, focusing on the potential young adult milestones of high school and college graduation, employment, residential independence, romantic partnership, and parenthood. Data came from a prospective‐longitudinal multi‐method study with N = 1199 participants who were first assessed at age 5 years old and followed to age 31. An accumulation of positive transitions in young adulthood (age 25) was associated with lower likelihood of age 31 problematic cannabis use. The protective effect for problematic cannabis use remained even when adjusting for childhood adverse family environments and was primarily driven by successful college graduation and/or home ownership. The accumulation of positive transitions protected individuals at modest to somewhat elevated risk due to childhood adverse family environments from experiencing age 31 cannabis use problems. However, for other individuals with very high numbers of conduct problems, or with high levels of adolescent substance use, the protective effects of accumulated positive transitions to young adulthood were less strong or nonexistent. Moreover, individuals who completed college or obtained full‐time employment by 25 were more likely to report problematic age 31 alcohol use. These findings highlight the central tenets of John Schulenberg's developmental framework, including the examination of ontogenetic continuity and discontinuity, the interplay of developmentally distal and proximal effects, and the identification of developmental protective factors that may sway people toward or away from substance use.
Improving growth models of cultivated sugar kelp, Saccharina latissima, by accounting for intraspecific variation in thermal tolerance
Authors: Krasnow Ruby , Gonzalez Sara , Lindell Scott 
Published: June 2024

AbstractDynamic models of sugar kelp (Saccharina latissima) growth are used to estimate the production potential of seaweed aquaculture in many regions around the world. These models do not currently account for the existence of S. latissima ecotypes that are adapted to regional environmental conditions, particularly temperature. We tested the hypothesis that recalibrating the temperature parameters of a dynamic energy budget model using literature data for S. latissima from regions with a similar climate to the region of interest would result in more accurate predictions than using a general species‐wide temperature response curve. Calibrating the model using data from warm regions significantly improved model accuracy for kelp cultivation at the southern end of the species range (Rhode Island, USA) in cases where the original parameters underestimated growth but resulted in drastic overestimates when heavy frond erosion occurred. In Trømso, Norway, a cold parameterization produced extremely accurate predictions: the model predicted a final frond length of 88.2 cm, compared with the observed length of 87.5 (±4.70) cm. Our results demonstrate that recalibrating temperature response curves allows one model to be applied to kelp aquaculture in different regions, an important step toward the prediction of S. latissima productivity over large areas.
The new definition of dominant stricture in primary sclerosing cholangitis: Prevalence and clinical significance
Authors: Thylin Mathias , Färkkilä Martti , Kautiainen Hannu , Barner‐Rasmussen Nina , Jokelainen Kalle , Puustinen Lauri , Boyd Sonja , Arola Johanna , Tenca Andrea 
Published: June 2024

AbstractBackground and AimsA new definition of dominant stricture (NDS) has recently been defined for patients with primary sclerosing cholangitis (PSC). Prevalence and clinical features of this, compared to traditional dominant stricture (TDS), have not been reported.MethodsIn this single‐centre longitudinal prospective cohort study, all PSC patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) between October 2021 and 2022 were recruited. Symptoms of cholestasis, laboratory values (P‐alkaline phosphatase, P‐Bilirubin), Helsinki PSC‐score, brush cytology findings and need for endoscopic therapy (i.e. dilation, stenting) were prospectively collected.ResultsOverall, 228 patients with PSC underwent 248 ERCPs. NDS was detected in 43 (17%; 36 patients) and TDS without NDS (TDS group) was detected in 62 (25%; 58 patients) ERCPs, respectively; in the remaining 143 ERCPs, neither TDS nor NDS was seen (no dominant stricture [NoDS] group). PSC duration (median 8 years) and patient's age did not differ between the three groups; males presented more often with NDS. Patients with NDS were more often symptomatic, had higher cholestatic liver enzymes, advanced bile duct disease and markers of biliary inflammation (p < .001). Patients with NDS needed dilation (81%) and stenting (21%) more often than the TDS group (60% and 5%, respectively). Dysplasia in brush cytology was more common in TDS (5%) and NDS (9%) than in NoDS (3%) groups (p = .04), but did not differ between TDS and NDS groups.ConclusionsDominant stricture according to the new definition developed in 17% of PSC patients in our cohort and identifies patients with more advanced disease, biliary inflammation and need of endo‐therapy.
Habitual use of glucosamine and adverse liver outcomes among patients with type 2 diabetes and MASLD
Authors: Shen Yun , Wang Yaxin , Lu Jingyi , Mo Yifei , Ma Xiaojing , Hu Gang , Zhou Jian 
Published: June 2024

AbstractBackgroundGlucosamine is a dietary supplement commonly used to support joint health. However, there has been interest in exploring other effects of glucosamine on health outcomes due to its ant‐inflammation effect.ObjectiveThis study compared the risks of major adverse liver outcomes (MALOs) between regular users and non‐users of glucosamine among patients with type 2 diabetes and metabolic dysfunction associated steatotic liver disease (MASLD) using the data from a large prospective cohort study.MethodsDemographic, anthropometric, laboratory and medication prescription information among 18 753 patients with type 2 diabetes and MASLD was obtained from the UK Biobank. MASLD was identified based on hepatic steatosis defined by fatty liver index ≥60 plus the presence of any clues of metabolic dysregulation and cardio‐metabolic risk factors, excluding patients with moderate to severe alcohol consumption.ResultsDuring a mean follow‐up of 11.4 years, 826 incident MALOs events were recorded. Patients not regularly using glucosamine compared with patients using glucosamine showed a significantly higher risk of the composite MALOs (HR 1.36, 95% confidence interval [CI] 1.09–1.69) as well as most individual MALOs except for ascites. The multivariable‐adjusted HRs of MALOs within 3, 5 and 10 years among non‐users of glucosamine compared with regular users were 1.79 (95% CI .69–2.03), 1.88 (95% CI 1.21–2.54) and 1.32 (95% CI 1.05–1.72), respectively. Further subgroup analyses in participants with different baseline characteristics and sensitivity analyses excluding participants who regularly took any other supplements and participants who used self‐reports to diagnose diabetes confirmed the findings.ConclusionsThe present study indicated that habitual use of glucosamine was associated with a low risk of individual and composite MALOs among patients with type 2 diabetes and MASLD.