bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Dynamic Crust of Northern Afar and Adjacent Rift Margins: New Evidence From Receiver Function Analysis in Eritrea and Ethiopia
Authors: Gauntlett M. , Stephenson S. N. , Kendall J.‐M. , Ogden C. , Hammond J. O. S. , Hudson T. , Goitom B. , Ogubazghi G. 
Published: June 2024

AbstractAfar is undergoing the final stages of continental rifting and hosts the triple junction between the Red Sea, Gulf of Aden, and Main Ethiopian rifts. To better understand the nature of the crust and continental breakup in the region, we calculate teleseismic receiver functions across northeastern Afar and the Danakil microplate, using new data from a regional deployment in Eritrea. We estimate the Moho depth and bulk crustal VP/VS ratio using the H‐κ stacking method. The heterogeneity of our crustal thickness estimates (∼19–35 km) indicates that the Danakil microplate has undergone stretching and crustal thinning. By investigating the relationship between crustal thickness and topographic elevation, we estimate the regional crustal bulk density as ρc ≈ 2,850 ± 20 kg m−3, which is higher than expected, given the crustal thickness of the region. We show that topography is 1.5 ± 0.4 km higher than would be expected due to crustal isostasy alone. We propose that this topography is supported by the same hot mantle upwelling suggested to be responsible for the onset of rifting in East Africa. Uplift is generated due to the presence of a hot thermal anomaly beneath the plate and by thinning of the lithospheric mantle. Our results are consistent with a number of independent constraints on the thermal structure of the asthenospheric and lithospheric mantle. Evidence of melt within the crust is provided by anomalously high VP/VS ratios of >1.9, demonstrating that magma‐assisted extension continues to be important in the final stages of continental breakup.
Shaken and Stirred: A Comparative Study of Earthquake‐Triggered Soft‐Sediment Deformation Structures in Lake Sediments
Authors: Molenaar Ariana , Wils Katleen , Van Daele Maarten , Daxer Christoph , Dubois Nathalie , Grießer Anja , Oswald Patrick , Ramisch Arne , Strasser Michael , Moernaut Jasper 
Published: June 2024

AbstractSubaqueous paleoseismic studies used soft sediment deformation structures (SSDS) to discern the shaking strength of past earthquakes, as the deformation degree of SSDS related to Kelvin Helmholtz Instability evolves from disturbed lamination and folds to intraclast breccia with higher peak ground accelerations (PGA). We lack comparative studies of different sediment types with SSDS related to earthquakes from different seismogenic sources to comprehend how these factors modulate earthquake‐induced deformation. Here, we compile sediment records with seven earthquake‐triggered SSDS from 10 lakes with organic‐, carbonate‐, siliciclastic‐, and diatom‐rich sediment from three subduction zones and one collisional setting. We target basin sequences with slope angles <0.65° to reduce the influence of gravitational downslope stress. We find that even minimal increases in slope angle, maximal 1°, lead to higher deformation degrees and, for some earthquakes, SSDS are only present at >0.65°. Fine‐grained clastics enhance sediment susceptibility to deformation, whereas abundant diatoms reduce it, demonstrating the influence of composition. Deformation correlates best with PGA and the vicinity of the earthquakes, suggesting that high frequency shaking promotes deformation. In addition, deformation only occurs above a minimum magnitude dependent on sediment composition, and higher deformation degrees in our studied basin sedimentary sequences only above Mw 4.9 for all sediment types, suggesting that sufficient duration of shaking—magnitude correlates with duration—is essential for SSDS development. We advise taking multiple cores on gentle slopes to study SSDS—additional to basin cores—to resolve small magnitude local earthquakes and relative differences in frequency content of past events.
Climate Change Is Leading to a Convergence of Global Climate Distribution
Authors: Li Chuanhua , Liu Cui , Tsunekawa Atsushi , Liu Yunfan , Yin Peng , Ma Shaoxiu , Zhou Min , Wu Xiaodong 
Published: June 2024

AbstractThe impact of changes in global temperatures and precipitation on climate distribution remains unclear. Taking the annual global average temperatures and precipitation as the origin, this study determined the climate distribution with the distances of temperature and precipitation from their global averages as the X and Y axes. The results showed that during 1980–2019, the global temperature distribution converged toward the mean (convergence), while the precipitation distribution moved away from the mean (divergence). The combined effects of both led to a convergence in the global climate distribution. During 2025–2100, significant climate convergence is observed under two emission scenarios (SSP245 and SSP585). However, the climate convergence and the area of change in climate type remains insignificant only under SSP126, suggesting that the diversity of the global climate pattern can be maintained under a sustainable emission pathway (SSP126), whereas high emission pathways will lead to greater uniformity in global climate.
Improving Coastal Storm Surge Monitoring Through Joint Modeling Based on Permanent and Temporary Tide Gauges
Authors: Yang Lianjun , Jin Taoyong , Jiang Weiping 
Published: June 2024

AbstractWith climate change, there will be higher requirements for monitoring storm surges (SSs) in nearshore areas. However, this capability is limited by the sparseness of tide gauge (TG) stations. Establishing and maintaining a permanent, high‐spatial coverage, in situ TG network is complex and expensive. Here, we propose a joint modeling method developed from the all‐site modeling data‐driven framework by importing temporary TGs into coastal regions with insufficient permanent TG stations. The assessments show that this method can significantly optimize the capability of extreme SS monitoring during typhoons and hurricanes. Moreover, the evaluation based on Coupled Model Intercomparison Project Phase 6 data indicates that it will monitor extreme SSs more effectively during 2025–2050 compared with only using existing permanent in situ TGs (reducing root mean square error and absolute mean bias by ∼50%). The joint modeling method provides an applicable and sustainable solution for optimizing the SS monitoring capability in coastal areas.
Different Dynamics Drive Indian Ocean Moisture to the Southern Slope of Central Himalayas: An Isotopic Approach
Authors: Guo Rong , Yu Wusheng , Zhang Jingyi , Lewis Stephen , Lazhu  , Ma Yaoming , Xu Baiqing , Wu Guangjian , Jing Zhaowei , Ren Pengjie , Zhang Zhuanxia , Wang Qiaoyi , Qu Dongmei 
Published: June 2024

AbstractThis study uses precipitation oxygen isotopes (δ18Op) to examine key dynamics that deliver moisture to the southern slope of central Himalayas over different seasons. Results show that the majority of pre‐monsoon δ18Op values are relatively high and controlled by the westerlies and local moisture. However, some abnormally low δ18Op values coincide with higher precipitation amounts during the pre‐monsoon season due to moisture driven northwards from the Bay of Bengal and Arabian Sea to central Himalayas by anomalous circulations (quasi‐anticyclone, anticyclone, or/and westerlies trough). The size and location of the quasi‐anticyclone also influences the magnitude of the δ18Op decrease. In comparison, the monsoon δ18Op values are lower due to the combined effects of the Indian summer monsoon and convection. Our findings indicate that researchers need to consider the signals of abnormally low δ18Op values during the pre‐monsoon season when attempting to interpret ice core and tree‐ring records from central Himalayas.
Differential methylation of OPRK1 in borderline personality disorder is associated with childhood trauma
Authors: Gescher Dorothee Maria , Schanze Denny , Vavra Peter , Wolff Philip , Zimmer-Bensch Geraldine , Zenker Martin , Frodl Thomas , Schmahl Christian 
Published: June 2024

AbstractAccording to a growing body of neurobiological evidence, the core symptoms of borderline personality disorder (BPD) may be linked to an opioidergic imbalance between the hedonic and stimulatory activity of mu opioid receptors (MOR) and the reward system inhibiting effects of kappa opioid receptors (KOR). Childhood trauma (CT), which is etiologically relevant to BPD, is also likely to lead to epigenetic and neurobiological adaptations by extensive activation of the stress and endogenous opioid systems. In this study, we investigated the methylation differences in the promoter of the KOR gene (OPRK1) in subjects with BPD (N = 47) and healthy controls (N = 48). Comparing the average methylation rates of regulatorily relevant subregions (specified regions CGI-1, CGI-2, EH1), we found no differences between BPD and HC. Analyzing individual CG nucleotides (N = 175), we found eight differentially methylated CG sites, all of which were less methylated in BPD, with five showing highly interrelated methylation rates. This differentially methylated region (DMR) was found on the falling slope (5’) of the promoter methylation gap, whose effect is enhanced by the DMR hypomethylation in BPD. A dimensional assessment of the correlation between disease severity and DMR methylation rate revealed DMR hypomethylation to be negatively associated with BPD symptom severity (measured by BSL-23). Finally, analyzing the influence of CT on DMR methylation, we found DMR hypomethylation to correlate with physical and emotional neglect in childhood (quantified by CTQ). Thus, the newly identified DMR may be a biomarker of the risks caused by CT, which likely epigenetically contribute to the development of BPD.
Neural mechanisms of psychedelic visual imagery
Authors: Stoliker Devon , Preller Katrin H. , Novelli Leonardo , Anticevic Alan , Egan Gary F. , Vollenweider Franz X. , Razi Adeel 
Published: June 2024

AbstractVisual alterations under classic psychedelics can include rich phenomenological accounts of eyes-closed imagery. Preclinical evidence suggests agonism of the 5-HT2A receptor may reduce synaptic gain to produce psychedelic-induced imagery. However, this has not been investigated in humans. To infer the directed connectivity changes to visual connectivity underlying psychedelic visual imagery in healthy adults, a double-blind, randomised, placebo-controlled, cross-over study was performed, and dynamic causal modelling was applied to the resting state eyes-closed functional MRI scans of 24 subjects after administration of 0.2 mg/kg of the serotonergic psychedelic drug, psilocybin (magic mushrooms), or placebo. The effective connectivity model included the early visual area, fusiform gyrus, intraparietal sulcus, and inferior frontal gyrus. We observed a pattern of increased self-inhibition of both early visual and higher visual-association regions under psilocybin that was consistent with preclinical findings. We also observed a pattern of reduced inhibition from visual-association regions to earlier visual areas that indicated top-down connectivity is enhanced during visual imagery. The results were analysed with behavioural measures taken immediately after the scans, suggesting psilocybin-induced decreased sensitivity to neural inputs is associated with the perception of eyes-closed visual imagery. The findings inform our basic and clinical understanding of visual perception. They reveal neural mechanisms that, by affecting balance, may increase the impact of top-down feedback connectivity on perception, which could contribute to the visual imagery seen with eyes-closed during psychedelic experiences.
Proactive monitoring of drug–drug interactions between direct oral anticoagulants and small-molecule inhibitors in patients with non-small cell lung cancer
Authors: Gulikers Judith L. , Otten Leila-Sophie , Hendriks Lizza E. L. , Winckers Kristien , Henskens Yvonne , Leentjens Jenneke , van den Heuvel Michel M. , ter Heine Rob , Croes Sander , Piet Berber , van Geel Robin M. J. M. 
Published: June 2024

Abstract
Background
Small-molecule inhibitors (SMIs) have revolutionised the treatment of non-small cell lung cancer (NSCLC). However, SMI-induced drug–drug interactions (DDIs) with frequently co-administered direct oral anticoagulants (DOACs), increase thromboembolic and bleeding risks. This study investigated and proactively managed the consequences of DOAC-SMI DDIs.

Methods
This prospective, observational study enrolled patients with NSCLC concomitantly using a DOAC and SMI. The primary outcome was the proportion of patients with DOAC plasma trough (Ctrough) and peak (Cpeak) concentrations outside expected ranges. Secondary outcomes included DOAC treatment modifications, incidence of bleeding and thromboembolic events and feasibility evaluation of pharmacokinetically guided DOAC dosing.

Results
Thirty-three patients were analysed. Thirty-nine percent (13/33) had DOAC Ctrough and/or Cpeak were outside the expected ranges in 39% (13/33). In 71% (5/7) of patients with DOAC concentrations quantified before and during concurrent SMI use, DOAC Ctrough and/or Cpeak increased or decreased >50% upon SMI initiation. In all patients in whom treatment modifications were deemed necessary, DOAC concentrations were adjusted to within the expected ranges.

Conclusion
Proactive monitoring showed that a substantial proportion of patients had DOAC concentrations outside the expected ranges. DOAC concentrations were successfully normalised after treatment modifications. These results highlight the importance of proactive monitoring of DOAC-SMI DDIs to improve treatment in patients with NSCLC.
Traumatic optic neuropathy management: a systematic review
Authors: Blanch Richard J. , Joseph Iric John , Cockerham Kimberly 
Published: June 2024

Abstract
Background
Traumatic optic neuropathy is classically described in up to 8% of patients with traumatic brain injury (TBI), but subclinical or undiagnosed optic nerve damage is much more common. When more sensitive testing is performed, at least half of patients with moderate to severe TBI demonstrate visual field defects or optic atrophy on examination with optical coherence tomography. Acute optic nerve compression and ischaemia in orbital compartment syndrome require urgent surgical and medical intervention to lower the intraocular pressure and diminish the risk of permanent optic nerve dysfunction. Other manifestations of traumatic optic neuropathy have more variable treatments in international practice.

Methods
We conducted a systematic review of traumatic optic neuropathy treatments in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement.

Results
We included three randomised controlled trials of intravenous methylprednisolone (IVMP), erythropoietin, and levodopa-carbidopa combination, with no evidence of benefit for any treatment. In addition, large studies in TBI have found strong evidence of increased mortality in patients treated with megadose IVMP.

Conclusions
There is therefore no evidence of benefit for any medical treatment and strong evidence of harm from IVMP. There is also no evidence of benefit for optic canal decompression for traumatic optic neuropathy. Orbital compartment syndrome is a separate entity that requires both medical and surgical interventions to prevent visual loss.
Human milk affects TLR4 activation and LPS-induced inflammatory cytokine expression in Caco-2 intestinal epithelial cells
Authors: Pizzarello Catherine R. , Nelson Ashley , Verekhman Ilya , Seppo Antti E. , Järvinen Kirsi M. 
Published: June 2024

AbstractHuman milk (HM) components affect immune cell toll-like receptor 4 (TLR4) signaling. However, studies examining the immunomodulatory impacts of HM on TLR4 signaling in intestinal epithelial cells (IECs) are limited. This study utilized both a TLR4 reporter cell line and a Caco-2 IEC model to examine the effects of HM on lipopolysaccharide (LPS)-induced TLR4 activation and cytokine responses, respectively. Additionally, we performed fast protein liquid chromatography and mass spectrometry to identify a HM component that contributes to the effect of HM on LPS/TLR4 signaling. HM enhances LPS-induced TLR4 signaling as well as LPS-induced IEC gene expression of pro-inflammatory cytokines and negative regulators of NF-κB. Human serum albumin (HSA) present in HM contributes to these effects. HSA within HM synergizes with LPS to induce IEC gene expression of pro-inflammatory cytokines and negative regulators of NF-κB. Altogether, this study provides mechanistic evidence behind the immunomodulatory function of HM on IECs, which may contribute to an enhanced immune response in breast-fed neonates.
Development and validation of a machine learning-based readmission risk prediction model for non-ST elevation myocardial infarction patients after percutaneous coronary intervention
Authors: Liu Yanxu , Du Linqin , Li Lan , Xiong Lijuan , Luo Hao , Kwaku Eugene , Mei Xue , wen Cong , Cui Yang Yang , Zhou Yang , Zeng Lang , Li Shikang , Wang Kun , Zheng Jiankang , Liu Zonglian , Hu Houxiang , Yue Rongchuan 
Published: June 2024

AbstractTo investigate the factors that influence readmissions in patients with acute non-ST elevation myocardial infarction (NSTEMI) after percutaneous coronary intervention (PCI) by using multiple machine learning (ML) methods to establish a predictive model. In this study, 1576 NSTEMI patients who were hospitalized at the Affiliated Hospital of North Sichuan Medical College were selected as the research subjects. They were divided into two groups: the readmitted group and the non-readmitted group. The division was based on whether the patients experienced complications or another incident of myocardial infarction within one year after undergoing PCI. Common variables selected by univariate and multivariate logistic regression, LASSO regression, and random forest were used as independent influencing factors for NSTEMI patients’ readmissions after PCI. Six different ML models were constructed using these common variables. The area under the ROC curve, accuracy, sensitivity, and specificity were used to evaluate the performance of the six ML models. Finally, the optimal model was selected, and a nomogram was created to visually represent its clinical effectiveness. Three different methods were used to select seven representative common variables. These variables were then utilized to construct six different ML models, which were subsequently compared. The findings indicated that the LR model exhibited the most optimal performance in terms of AUC, accuracy, sensitivity, and specificity. The outcome, admission mode (walking and non-walking), communication ability, CRP, TC, HDL, and LDL were identified as independent predicators of readmissions in NSTEMI patients after PCI. The prediction model constructed by the LR algorithm was the best. The established column graph model established proved to be effective in identifying high-risk groups with high accuracy and differentiation. It holds a specific predictive value for the occurrence of readmissions after direct PCI in NSTEMI patients.
Functional lower extremity strength influences stepping strategy in community-dwelling older adults during single and dual-task walking
Authors: Peoples Brandon M. , Harrison Kenneth D. , Santamaria-Guzman Keven G. , Campos-Vargas Silvia E. , Monaghan Patrick G. , Roper Jaimie A. 
Published: June 2024

AbstractAs age increases, a decline in lower extremity strength leads to reduced mobility and increased fall risks. This decline outpaces the age-related reduction in muscle mass, resulting in mobility limitations. Older adults with varying degrees of mobility-disability use different stepping strategies. However, the link between functional lower extremity strength and stepping strategy is unknown. Therefore, understanding how age-related reductions in functional lower extremity strength influence stepping strategy is vital to unraveling mobility limitations. Twenty participants (17F, 72 ± 6 years) were recruited and tested at a local community event. Participants were outfitted with inertial measurement units (IMU) and walked across a pressurized walkway under single and dual motor task conditions (walking with and without carrying a tray with water) at their usual and fast speeds. Participants were dichotomized into normal (11) or low functional strength groups (9) based on age-specific normative cutoffs using the instrumented 5-repetition Sit-to-Stand test duration. Our study reveals that older adults with normal strength prefer adjusting their step time during walking tasks, while those with reduced strength do not exhibit a preferred stepping strategy. This study provides valuable insights into the influence of functional lower extremity strength on stepping strategy in community-dwelling older adults during simple and complex walking tasks. These findings could aid in diagnosing gait deviations and developing appropriate treatment or management plans for mobility disability in older adults.
Correlation of CT features of lung adenocarcinoma with sex and age
Authors: Yang Yanli , Gao Yiyi , Lu Fang , Wang Ernuo , Liu Haiquan 
Published: June 2024

AbstractThis study aimed to retrospectively examine the computed tomography (CT) features of lung adenocarcinoma across different demographic groups. Preoperative chest CT findings from 1266 surgically resected lung adenocarcinoma cases were retrospectively analyzed. Lung adenocarcinomas were categorized based on CT characteristics into pure ground glass (pGGO), nodule-containing ground glass opacity (mGGO), and pure solid without containing ground glass opacity (pSD). These categories were correlated with sex, age, EGFR status, and five histopathological subtypes. The diameters of pGGO, mGGO, and pSD significantly increased across all patient groups (P < 0.05). Males exhibited a significantly higher proportion of pSD than females (P = 0.002). The mean diameters of pGGO and pSD were significantly larger in males than in females (P = 0.0017 and P = 0.043, respectively). The frequency of pGGO was higher in the younger age group (≤ 60 years) compared to the older group (> 60 years) for both males (P = 0.002) and females (P = 0.027). The frequency of pSD was higher in the older age group for both sexes. A linear correlation between age and diameter was observed in the entire cohort as well as in the male and female groups (P < 0.0001 for all groups). EGFR mutations were less frequent in pSD compared to pGGO (P = 0.0002) and mGGO (P < 0.0001). The frequency of lesions containing micropapillary components increased from pGGO to mGGO and pSD (P < 0.0001 for all). The frequency of lesions containing solid components also increased from pGGO to mGGO and pSD (P = 0.045, P < 0.0001, and P < 0.0001, respectively). The CT features of lung adenocarcinoma exhibit differences across genders and age groups. Male gender and older age are risk factors for lung adenocarcinoma growth.