bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reflecting on multisite evaluation practice
Authors: King Jean A. , Ross Patricia A. , Callow‐Heusser Catherine , Gullickson Arlen R. , Lawrenz Frances , Weiss Iris R. 
Published: March 2011

AbstractThe lead evaluators for four large‐scale multisite National Science Foundation evaluations discuss their experiences across time and space to explicate what they have learned as six lessons that may be of use to other multisite practitioners. The lessons relate to the control of decisions, use of the evaluation process and outcomes, supporting project staff in their evaluation work, serving as a buffer between the funder and projects, taking purposeful leadership around cultural issues, and the importance of high‐quality evaluation designs. © Wiley Periodicals Inc., and the American Evaluation Association.
Relationship between duration of exposure and anxiolytic‐like effects of essential oil from Alpinia zerumbet
Authors: Satou Tadaaki , Kasuya Hikaru , Takahashi Mizuho , Murakami Shio , Hayashi Shinichiro , Sadamoto Kiyomi , Koike Kazuo 
Published: March 2011

ABSTRACTSeveral reports have described the relationship between the quantity of an essential oil (EO), delivered by injection, and the effects on emotional behaviour. However, few studies have examined the relationship between the duration of EO inhalation and effects on emotional behaviour. It is necessary to clarify this relationship to accomplish effective utilization of an EO. Therefore, we aimed to clarify the relationship between EO inhalation time and anxiolytic‐like effects. The anxiolytic‐like effect of inhaled EO at various administration times was examined in normal healthy mice using the elevated‐plus maze (EPM) test. The effect of a dose of 3.5 mg/l air of Alpinia zerumbet EO was assessed using the EPM test. A time‐dependent potentiation in the anxiolytic‐like effect was observed when the inhalation time was altered from 0 to 120 min. A significant (P < 0.05 compared to time 0) anxiolytic‐like effect was observed to peak at inhalation times of 90 and 120 min. However, the anxiolytic‐like effect returned to normal with a 150‐min exposure. There was an optimal time of EO inhalation for expressing an anxiolytic‐like effect. Copyright © 2011 John Wiley & Sons, Ltd.
Spurious Forecasts?
Authors: Martínez‐Rivera Berenice , Ventosa‐Santaulària Daniel , Eduardo Vera‐Valdés J. 
Published: March 2011

ABSTRACTP. C. B. Phillips (1998) demonstrated that deterministic trends are a valid representation of an otherwise stochastic trending mechanism; he remained skeptic, however, about the predictive power of such representations. In this paper we prove that forecasts built upon spurious regression may perform (asymptotically) as well as those issued from a correctly specified regression. We derive the order in probability of several in‐sample and out‐of‐sample predictability criteria ( test, root mean square error, Theil's U‐statistics and R2) using forecasts based upon a least squares‐estimated regression between independent variables generated by a variety of empirically relevant data‐generating processes. It is demonstrated that, when the variables are mean stationary or trend stationary, the order in probability of these criteria is the same whether the regression is spurious or not. Simulation experiments confirm our asymptotic results. Copyright © 2011 John Wiley & Sons, Ltd.
Genome profiling of pancreatic adenocarcinoma
Authors: Birnbaum David J. , Adélaïde José , Mamessier Emilie , Finetti Pascal , Lagarde Arnaud , Monges Geneviève , Viret Frédéric , Gonçalvès Anthony , Turrini Olivier , Delpero Jean‐Robert , Iovanna Juan , Giovannini Marc , Birnbaum Daniel , Chaffanet Max 
Published: March 2011

AbstractPancreatic adenocarcinoma is one of the most aggressive human cancers. It displays many different chromosomal abnormalities and mutations. By using 244 K high‐resolution array‐comparative genomic hybridization (aCGH) we studied the genome alterations of 39 fine‐needle aspirations from pancreatic adenocarcinoma and eight human adenocarcinoma pancreatic cell lines. Using both visual inspection and GISTIC analysis, recurrent losses were observed on 1p, 3p, 4p, 6, 8p, 9, 10, 11q, 15q, 17, 18, 19p, 20p, 21, and 22 and comprised several known or suspected tumor suppressor genes such as ARHGEF10, ARID1A, CDKN2A/B, FHIT, PTEN, RB1, RUNX1‐3, SMAD4, STK11/LKB1, TP53, and TUSC3. Heterozygous deletion of the 1p35‐p36 chromosomal region was identified in one‐third of the tumors and three of the cell lines. This region, commonly deleted in human cancers, contains several tumor suppressor genes including ARID1A and RUNX3. We identified frequent genetic gains on chromosome arms 1q, 3q, 5p, 6p, 7q, 8q, 12q, 15q, 18q, 19q, and 20q. Amplifications were observed in 16 tumors. AKT2, CCND3, CDK4, FOXA2, GATA6, MDM2, MYC, and SMURF1 genes were gained or amplified. The most obvious amplification was located at 18q11.2 and targeted the GATA6 gene, which plays a predominant role in the initial specification of the pancreas and in pancreatic cell type differentiation. In conclusion, we have identified novel biomarkers and potential therapeutic targets in pancreatic adenocarcinoma. © 2011 Wiley‐Liss, Inc.
An evolutionary Bayesian belief network methodology for participatory decision making under uncertainty: An application to groundwater management
Authors: Farmani Raziyeh , Henriksen Hans Jørgen , Savic Dragan , Butler David 
Published: March 2011

Abstract
An integrated participatory approach based on Bayesian belief network (BBN) and evolutionary multiobjective optimization is proposed as an efficient decision-making tool in complex management problems. The proposed methodology incorporates all the available evidence and conflicting objectives to evaluate implications of alternative actions in the decision-making process and suggests best decision pathways under uncertainty. A BBN provides a framework within which the contributions of stakeholders can be taken into account. It allows a range of different factors and their probabilistic relationship to be considered simultaneously. It takes into account uncertainty by assigning probability to those variables whose states are not certain. The integration of BBN with evolutionary multiobjective optimization allows the analysis of tradeoff between different objectives and incorporation and acknowledgement of a broader set of decision goals into the search and decision-making process. The proposed methodology can be used as a decision support tool to model decision-making processes for complex problems. It deals with uncertainties in decision making pertaining to human behavior and checks for consistency of the developed BBN structure and the parameters of the probabilistic relationship by uncovering discrepancies in the decision analysis process (e.g., bias in completeness or redundancy of the model based on a utility function). It generates a set of efficient management options (appropriate combinations of interventions) that balances conflicting objectives. The effectiveness of the proposed methodology is discussed through application to a real case study. It is shown that it successfully identifies any inconsistencies in the developed BBN models and generates large numbers of management options that achieve an optimal tradeoff between different objectives. Integr Environ Assess Manag 2012; 8: 456–461. © SETAC
On strongly almost trivial embeddings of graphs
Authors: Hanaki Ryo 
Published: March 2011

AbstractWe present four new classes of graphs, two of which every member has a strongly almost trivial embedding, and the other two of which every member has no strongly almost trivial embeddings. We show that the property that a graph has a strongly almost trivial embedding and the property that a graph has no strongly almost trivial embeddings are not inherited by minors. Copyright © 2011 Wiley Periodicals, Inc. J Graph Theory
Automorphism group and diameter of a graph
Authors: Dankelmann P. , Erwin D. , Mukwembi S. , Rodrigues B. G. , Mwambene E. , Sabidussi G. 
Published: March 2011

AbstractGiven a connected graph Γ of order n and diameter d, we establish a tight upper bound for the order of the automorphism group of Γ as a function of n and d, and determine the graphs for which the bound is attained. © 2011 Wiley Periodicals, Inc. J Graph Theory.
The NH(C)Br functionality of heteroaromatic compounds as a synthon for fused dihydrooxazoles
Authors: Cegla Marek T. , Baran Marzena , Czarny Agnieszka , Zylewski Marek , Potaczek Joanna , Klenc Jeff , Strekowski Lucjan 
Published: March 2011

AbstractFused dihydrooxazoles are produced by the reaction of 8‐bromoteophylline (1), 6‐bromo‐2‐pyridone (7), or 2‐bromobenzimidazole (11) with an N‐substituted N‐(2,3‐epoxypropyl)amine. The product derived from 1 undergoes rearrangement to a fused dihydrooxazine while the fused dihydrooxazoles derived from 7 and 11 are stable. J. Heterocyclic Chem., (2011).
Electrophilic substitution reaction of indole, part XXIV: Synthesis, characterization, and crystal structure of a novel heterocyclic compound
Authors: Nayak Anupam , Dutta Utpal , Prangé Thierry , Banerji Julie 
Published: March 2011

AbstractThe reaction of indole with cyclohexanone in the presence of the Lewis acid, boron trifluoride diethyl etherate, resulted in the synthesis of a novel and interesting product (1) in addition to the bis(indolyl)methane system (2). The structure of this novel compound has been determined by NMR (1H and 13C) and X‐ray crystal structure analysis. Compound 1 is a (1:2) addition reaction product of indole with cyclohexanone. The spiro six‐membered ring is in the classic chair conformation. An epoxide bridge at C‐4a/C‐10b and the two hydroxyl groups at C‐5a, C‐10a are all on the same side of the central five membered ring. J. Heterocyclic Chem., (2011).
Recent development for enantioselective synthesis of aromatic compounds from alkynes via metallacyclopentadienes
Authors: Li Shi , Zhou Lishan , Kanno Ken‐Ichiro , Takahashi Tamotsu 
Published: March 2011

AbstractMetallacyclopentadiene, which is recognized as a metallo‐heterocycle, is an important intermediate for the formation of aromatic derivatives. In this short review, we summarized the recent advance on construction of axial, central, planar, and helical chirality by transition‐metal‐catalyzed aromatic compounds formation via metallacyclopentadienes. J. Heterocyclic Chem., (2011).
Asking about well‐being gets you half an answer: Intra‐individual processes of implicit and explicit job attitudes
Authors: Leavitt Keith , Fong Christina T. , Greenwald Anthony G. 
Published: March 2011

AbstractJob attitudes, as indicators of well‐being, vary within individuals across cognitive processes and not just time. Research on employee well‐being has relied primarily on self‐reported measures of explicit job and life attitudes. Our work takes a different perspective on this issue by examining the role of implicit attitudes regarding one's organization, coworkers, and supervisor as indicators of well‐being. Implicit attitudes are automatic, introspectively inaccessible, and predict behavior in socially sensitive contexts in which self‐report measures may be impaired by impression management. The results of a field study demonstrate that implicit and explicit job attitudes reflect relatively independent intra‐individual processes. Additionally, this study demonstrates that job performance and citizenship behaviors are best predicted by a combination of implicit and explicit job attitudes, and that a dissociation between implicit and explicit attitudes impacts organizational identification. We conclude with a discussion of how capturing implicit cognition in the workplace can better describe and subsequently help improve employee well‐being. Copyright © 2011 John Wiley & Sons, Ltd.
Kinetic Modeling as a Tool to Understand and Improve the Nitroxide Mediated Polymerization of Styrene
Authors: Bentein Lien , D'hooge Dagmar R. , Reyniers Marie‐Françoise , Marin Guy B. 
Published: March 2011

AbstractKinetic modeling is used to obtain insight in the complex interplay between reaction rates and obtained polymer properties in the SG1 and the TEMPO mediated bulk polymerization of styrene at 396 K. The increase of the viscosity during NMP is accounted for. At higher targeted chain lengths, chain transfer to dimer and transfer from nitroxide to dimer are shown to cause the experimentally observed reduced control over the average polymer properties and to result in a clear fronting of the polymer chain length distribution. The potential of kinetic modeling to design tailor‐made synthesis strategies is illustrated. Simulations indicate that careful control of the polymerization conditions allows to obtain an important improvement of the polymer properties. The approach is also applicable for NMP mediated by other alkoxyamines/nitroxides and allows to expand the application range of NMP for styrene polymerization in particular to synthesize complex polymer architectures by assembly of functionalized polymers. magnified image
Assessing the SB‐V factor structure in a sample of preschool children
Authors: Ward Kimberly E. , Rothlisberg Barbara A. , McIntosh David E. , Bradley Madeline H. 
Published: March 2011

AbstractThe purpose of this study was to examine the factor structure of the Stanford‐Binet Intelligence Scales, Fifth Edition (SB‐V), based on the Cattell‐Horn‐Carroll (CHC) theory of intelligence using a sample of 200 preschool children. The CHC framework uses three different models: one similar to Spearman's g, one similar to the Gf‐Gc model, and one representing the hierarchical three‐stratum CHC model. A confirmatory factor analysis (CFA), utilizing these three models, was conducted to determine which theoretical model best described the ability structure measured by the SB‐V. Results of the CFA revealed that, although the two‐stratum model provided the best fit statistics, a large amount of overlap existed among the broad CHC factors in this model. Therefore, these results suggested that a simple, overall ability model may be the best representation of ability for preschool children when using the SB‐V because the factors appeared to be indistinct with this age group. © 2011 Wiley Periodicals, Inc.
Profile analysis of the Kaufman Assessment Battery for Children, Second Edition, with African American and Caucasian preschool children
Authors: Dale Brittany A. , McIntosh David E. , Rothlisberg Barbara A. , Ward Kimberly E. , Bradley Madeline Hunt 
Published: March 2011

AbstractThis study used profile analysis to investigate the interpretability of the Kaufman Assessment Battery for Children, Second Edition (KABC‐II), in terms of the Cattell‐Horn‐Carroll (CHC) theory among ethnically diverse preschool children. Forty‐nine African American and 49 Caucasian preschool children from a Midwestern city were included in the study and were matched for age, sex, and level of parental education. The profile analysis examining CHC broad abilities showed that the African American and Caucasian preschool children had similar patterns of highs and lows and performed at the same level with no significant difference between the two groups in their overall mean IQ. Profile analysis of the KABC‐II subtests found that although the African American and Caucasian groups performed overall at a similar level, they did not show the same pattern of highs and lows in subtest performance. Specifically, Caucasian preschoolers scored significantly higher than their African American counterparts on the Expressive Vocabulary subtest. Overall, the two groups displayed remarkably similar performance on the KABC‐II. © 2011 Wiley Periodicals, Inc.
Response‐to‐intervention in high‐risk preschools: Critical issues for implementation
Authors: Ball Carrie R. , Trammell Beth A. 
Published: March 2011

AbstractThis article summarizes the current knowledge of response‐to‐intervention (RTI) models in preschool settings, with an emphasis on evaluating the strengths and weaknesses of our current research base. Particular attention is given to the unique challenges of high‐risk preschool settings. Presently, sufficient empirical support exists to begin establishing tiered intervention systems and building teacher capacity. Lacking, however, are valid and reliable assessment tools and insufficiently trained personnel to support a data‐based decision‐model within high‐risk preschools. We conclude that organizational development should focus on building teacher capacity, establishing high‐quality classroom instruction, and planning for sustainable programs, with adoption of a full RTI service delivery model serving as a long‐range aspirational goal. © 2011 Wiley Periodicals, Inc.
Oxidative stress response in the opportunistic oral pathogen Fusobacterium nucleatum
Authors: Steeves Craig H. , Potrykus Joanna , Barnett David A. , Bearne Stephen L. 
Published: March 2011

AbstractThe anaerobic, Gram‐negative bacillus Fusobacterium nucleatum plays a vital role in oral biofilm formation and the development of periodontal disease. The organism plays a central bridging role between early and late colonizers within dental plaque and plays a protective role against reactive oxygen species. Using a two‐dimensional gel electrophoresis and mass spectrometry approach, we have annotated 78 proteins within the proteome of F. nucleatum subsp. nucleatum and identified those proteins whose apparent intracellular concentrations change in response to either O2‐ or H2O2‐induced oxidative stress. Three major protein systems were altered in response to oxidative stress: (i) proteins of the alkyl hydroperoxide reductase/thioredoxin reductase system were increased in intracellular concentration; (ii) glycolytic enzymes were modified by oxidation (i.e. D‐glyceraldehyde 3‐phosphate dehydrogenase, and fructose 6‐phosphate aldolase) or increased in intracellular concentration, with an accompanying decrease in ATP production; and (iii) the intracellular concentrations of molecular chaperone proteins and related proteins (i.e. ClpB, DnaK, HtpG, and HrcA) were increased.
Understanding the kinetic solvent effects on the 1,3‐dipolar cycloaddition of benzonitrile N‐oxide: a DFT study
Authors: Benchouk W. , Mekelleche S. M. , Silvi B. , Aurell M. J. , Domingo L. R. 
Published: March 2011

AbstractThe kinetic solvent effects on the 1,3‐dipolar cycloaddition (13DC) of benzonitrile N‐oxide with cyclopentene [T. Rispens and J. B. F. N. Engberts, J. Phys. Org. Chem. 2005; 18, 908–917] have been studied using density functional theory (DFT) at the B3LYP/6‐31G(d) level. Solvent effects were analyzed by means of the polarizable continuum model (PCM). The analysis of the potential energy surface shows that this reaction follows an asynchronous concerted mechanism. The topological analysis of the electron localization function (ELF) of the turning points along the reaction pathway explains the diradical nature of mechanism of this reaction. Inclusion of solvent effects does not substantially modify this behavior. The present study points out that, contrary to Diels–Alder reactions, the increase in the solvent polarity leads to a slow inhibition of the 13DC reaction, because of the low polarity of the transition state. Explicit solvation involving the coordination of one water molecule to the dipole puts in evidence the importance of hydrogen bonding in the modest acceleration of this 13DC reaction. These results are in good agreement with experimental outcomes. Copyright © 2011 John Wiley & Sons, Ltd.
Synthesis and characterization of soluble low‐bandgap oligothiophene‐[all]‐S,S‐dioxides‐based conjugated oligomers and polymers
Authors: Amir Elizabeth , Sivanandan Kulandaivelu , Cochran Justin E. , Cowart John J. , Ku Sung‐Yu , Seo Jung Hwa , Chabinyc Michael L. , Hawker Craig J. 
Published: March 2011

AbstractThe synthesis and characterization of a new family of soluble oligothiophene‐S,S‐dioxides and their use as building blocks to form polythiophene‐S,S‐dioxides via microwave‐assisted Stille coupling polymerization are described. Incorporation of the sulfone group into the polythiophene backbone leads to narrowing of the polymer bandgap, and while the energies of both Frontier orbitals in polythiophene‐S,S‐dioxide are lower with respect to polythiophenes, this tendency is considerably stronger for the lowest unoccupied molecular orbital than for the highest occupied molecular orbital, resulting in greater electron‐accepting ability. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Comparison of distance information in [TOAC1, Glu(OMe)7, 18, 19] alamethicin F50/5 from paramagnetic relaxation enhancement measurements with data obtained from an X‐ray diffraction‐based model
Authors: Jose Rani Alphonsa , De Zotti Marta , Peggion Cristina , Formaggio Fernando , Toniolo Claudio , De Borggraeve Wim M. 
Published: March 2011

AbstractPeptaibol antibiotics are membrane‐active linear peptides of fungal origin that are characterized by a high population of the Cα‐tetrasubstituted, strongly helicogenic, α‐amino acid, α‐aminoisobutyric acid, an N‐terminal acetyl group, and a C‐terminal 1,2‐amino alcohol. Alamethicins (Alms), among the longest peptaibiotics, are a group of closely sequence‐related peptides composed of 19 amino acid residues. [TOAC1, Glu(OMe)7, 18, 19] Alm and [TOAC16, Glu(OMe)7, 18, 19] Alm are synthetic, nitroxide free‐radical labeled analogs of [Glu(OMe)7, 18, 19] Alm F50/5. In this work, nitroxide to peptide NH proton distance information obtained from paramagnetic relaxation enhancement (PRE) studies on [TOAC1, Glu(OMe)7, 18, 19] Alm is compared with distances derived from an X‐ray diffraction‐based model. The methodology for PRE determination, as well as the generation of the X‐ray diffraction‐based model three‐dimensional structures, is discussed. The distances obtained from PRE measurements are in close agreement with the information derived from the X‐ray diffraction‐based model. This finding suggests that this type of information could be implemented as long‐range distance restraints in NMR‐based structure determination. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.
Discovery of potent, cyclic calcitonin gene‐related peptide receptor antagonists
Authors: Yan Liang Zeng , Johnson Kirk W. , Rothstein Emily , Flora David , Edwards Patrick , Li Baolin , Li Junqing , Lynch Renee , Vaughn Renee , Clemens‐Smith Amy , McCarty Deborah , Chow Charles , McKnight Kevin L. , Lu Jirong , Nisenbaum Eric S , Mayer John P. 
Published: March 2011

AbstractCalcitonin gene‐related peptide (CGRP), a potent dilator of cerebral and dural vasculature, is known to be elevated in plasma and cerebral spinal fluid during migraine attacks. Selective blockade of the CGRP receptor offers the promise of controlling migraine headache more effectively and without the side‐effects associated with the use of triptans. Our efforts to develop a novel, peptide‐based CGRP antagonist focused on the C‐terminal portion of the peptide which is known to bind the receptor but lack agonist properties. Extensive SAR studies of the C‐terminal CGRP (27–37) region identified a novel cyclic structure: Bz‐Val‐Tyr‐cyclo[Cys‐Thr‐Asp‐Val‐Gly‐Pro‐Phe‐Cys]‐Phe‐NH2 (23) with a kb value of 0.126 nM against the cloned human CGRP receptor. Additional SAR studies directed at enhancement of potency and improvement of physicochemical properties yielded a series of analogs with kb values in the 0.05–0.10 nM range. Copyright © 2011 European Peptide Society and John Wiley & Sons, Ltd.