bluuebunny/crossref_metadata_2025_split huggingface dataset:
The balance of national identify and ethic diversity in primary and secondary education in Kazakhstan: a textbook example
Authors: Нукэ Ч. 
Published: June 2024

данное исследование рассматривает представление национальной идентичности и этнического разнообразия в учебниках средних и младших школ Казахстана. Как многонациональное государство, система образования Казахстана сталкивается с вызовом формирования национальной идентичности, уважая и интегрируя этническое разнообразие. В данной работе через обзор литературы и анализ содержания учебников проведен мультидисциплинарный анализ конкретных способов представления национальной идентичности и этнического разнообразия, а также их взаимосвязи. Исследование показало, что учебники успешно формируют чувство национальной принадлежности у студентов через описание истории, культуры и национальных символов, одновременно способствуя осознанию и уважению этнического разнообразия через представление культуры и вклада различных народов. Тем не менее, остаются вызовы, связанные с обновлением содержания учебников и усилением представления культуры меньшинств. Данное исследование имеет важное значение для понимания баланса между национальной идентичностью и этническим разнообразием в образовательных системах Казахстана и других многонациональных стран, и предлагает новые перспективы и рекомендации для будущих исследований.
this study examines the representation of national identity and ethnic diversity in primary and secondary school textbooks in Kazakhstan. As a multi-ethnic country, Kazakhstan's education system faces the dual challenges of shaping national identity while respecting and integrating ethnic diversity. This paper conducts an interdisciplinary analysis of the specific presentations of national identity and ethnic diversity in textbooks, as well as their interrelationships, through a review of literature and textbook content analysis. The research finds that textbooks successfully foster a sense of national identity among students by describing history, culture, and national symbols, while also promoting awareness and respect for ethnic diversity through the introduction of different ethnic cultures and contributions. However, challenges remain in updating textbook content and enhancing the presentation of minority cultures. This study is significant for understanding the balance between national identity and ethnic diversity in the education systems of Kazakhstan and other multi-ethnic countries, and provides new perspectives and recommendations for future research.
Problems of distance education
Authors: Янь Л. 
Published: June 2024

дистанционное образование и его связь с новыми компьютерными технологиями в совокупности открывают много перспектив для сферы образования. Однако на практике возникает множество проблем и недостатков, некоторые из которых связаны с проблемами технологии; другие больше связаны с администрацией образовательного учреждения, методами обучения или студентами. Данное исследование знакомит с некоторыми тенденциями, которые влияют на дистанционное образование, и, таким образом, позволяет им планировать соответствующим образом. Темы и проблемы сгруппированы по категориям, поскольку они относятся к студентам, преподавателям, академическим кругам, технологиям, экономике и дистанционному образованию. Все эти вопросы и проблемы были выявлены в ходе обширного обзора современной литературы в этой области.
distance education and its connection with new computer technologies together open up many prospects for the field of education. However, in practice, there are many problems and disadvantages, some of which are related to technology issues; others are more related to the administration of an educational institution, teaching methods or students. This study introduces some of the trends that affect distance education and thus allows them to plan accordingly. Topics and issues are grouped into categories as they relate to students, teachers, academia, technology, economics, and distance education. All these questions and problems have been identified during an extensive review of the current literature in this field.
Labor de los enfermeros en la aspiración de secreciones de pacientes críticos [Nurses' work in the aspiration of secretions from critically ill patients]
Authors: Gómez-Martinez Nairovys 
Published: June 2024

Se tiene por objetivo de la investigación analizar la labor de los enfermeros en la aspiración de secreciones de pacientes críticos. Desde un enfoque de investigación del racionalismo crítico. Además el conocimiento de las medidas de bioseguridad ya que en dicho procedimiento se utiliza medidas de asepsia para evitar el riesgo de contraer infecciones adquiridas en el hospital, todo esto si no se cumple a cabalidad puede generar daños serios para la recuperación del paciente crítico, es por ello que el profesional de enfermería debe tomar conciencia en la preparación actualizada y continua, basándose en manuales, guías y protocolos con ayuda de las taxonomías de enfermería de manera que las actividades de enfermería lo realicen de forma secuencial y con fundamentos científicos, no como algo repetitivo.
Violencia contra personal de salud en salas de emergencias [Violence against health personnel in emergency rooms]
Authors: Comas-Rodríguez Raúl 
Published: June 2024

Se tiene por objetivo analizar la violencia contra personal de salud en salas de emergencias. Se trabajó con una investigación de tipo descriptiva documental, en una población bibliográfica de 15 articulos científicos, ubicados en Scielo, PubMed, Scopus. Los estudios analizados evidencian una alta tasa de violencia contra el personal sanitario en las áreas de emergencia, la cual se desarrolla desde los familiares de los pacientes, y otra en el interior de la institución como parte de acoso laboral. En ambos casos, se expone la debilidad o inexistencia de estrategias que permitan ejecutar una efectiva prevención contra la violencia, destacándose la necesidad de contar con programas educativos comunitarios con la intención de sensibilizar a los usuarios del hospital, sobre la importancia de tratar sin violencia al personal de salud. Esto implica una gran debilidad por parte de la gerencia de las instituciones hospitalarias.
EMPOWERMENT OF THE MALAHING TOURISM VILLAGE COMMUNITY IN THE DEVELOPMENT OF THE CREATIVE ECONOMY
Authors: Aznem Ahmad , Muhamad  , Nurhawaeny Endah 
Published: June 2024

This community service aims to understand the empowerment of the tourism village community in the Development of Ecotourism Potential in Malahing Tourism Village, Tanjung Laut Indah Village, South Bontang District, Bontang City, East Kalimantan Province. The main problem is the sustainability of the creative economy community empowerment program for the community, especially batik craftsmen. The research method used in qualitative descriptive research displays data as it is in Malahing Tourism Village without a process of manipulation or other treatments, including exposure and clarification of existing data from a phenomenon that occurs. PT Pupuk Kalimantan Timur's CSR approach is carried out holistically, including social responsibility programs by paying attention to social, economic, and environmental aspects that emphasize the sustainability of community development for strategic stakeholders. The study results show that community empowerment in Malahing Tourism Village can independently improve the quality of life without dependence on the program organizer, CSR (Corporate Social Responsibility) PT Pupuk Kalimantan Timur.
Carbon Stock Potential of Coconut Plantations in University Campus: A Case Study from Coimbatore, India
Authors: Pragasan L. Arul , Kalaiselvi M. 
Published: June 2024

The urgent need to mitigate climate change has prompted researchers to explore various avenues for carbon sequestration. One such avenue is the utilization of natural ecosystems like forests and plantations. Coconut plantations in university campuses play a vital role in carbon sequestration in mitigation of climate change. In this case study, we report the potential of coconut plantation from Bharathiar University campus, India. Four plots of 50 m × 50 m were randomly sampled from the coconut plantation in Bharathiar University campus. Carbon stock of the coconut plantation was calculated based on field survey and allometric equations. A total of 171 trees were recorded from the four plots totalling one hectare (ha) area. The total carbon stock determined for the one ha of coconut plantation sampled from Bharathiar University campus was 31.69 tonne/ha and the mean carbon stock per tree was 0.19 ± 0.06 tonne/tree. We have discussed the carbon stock of coconut tree allocation by above-ground and below-ground parts. This case study highlights the importance of coconut plantations in university campuses in support of curbing the atmospheric carbon concentration. We suggest for plantation of coconut trees in university campuses, that can serve not only as carbon sinks but also contribute to fulfilling the sustainable development goals of the nation.
An Alternative Approach to Direct Aldol Reaction Based on Gold‐Catalyzed Methoxyl Transfer
Authors: Zhang Moran , Wang Yunxia , Yang Yang , Hu Xiangdong 
Published: March 2012

AbstractA mild and catalyzed alternative to the direct aldol reaction has been developed based on the gold‐catalyzed methoxy group transfer from dimethyl acetals to terminal alkynes. Due to the simultaneous activation of the acetals, this aldol approach is only functional for acetals but not aldehydes. A ligand effect from the gold complex has also been observed.
Procurement Price Relationships for Fed Cattle and Hogs: Importance of the Cash Market in Price Discovery
Authors: Lee Yoonsuk , Ward Clement E. , Brorsen B. Wade 
Published: March 2012

ABSTRACTReduced reliance on cash markets for fed cattle and hogs raises questions about the role of cash prices in price discovery. Weekly data from mandatory price reports were used to determine whether cash market prices were cointegrated with and exhibited Granger causality with other procurement prices. Cash prices were cointegrated with all but one cattle and one hog procurement price series over the 2001–2010 period. Cash market prices Granger cause all other procurement prices and bidirectional causality was found in some but not all cases. Results for three 3‐year subperiods showed some decline in cointegration and causality for hogs. The cash market remains important for price discovery but continuing market thinness, especially in hogs, raises questions regarding viability of the cash market in the future.
Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene‐based case–control study and gene expression analysis
Authors: Ohi Kazutaka , Hashimoto Ryota , Yasuda Yuka , Fukumoto Motoyuki , Yamamori Hidenaga , Umeda‐Yano Satomi , Okada Takeya , Kamino Kouzin , Morihara Takashi , Iwase Masao , Kazui Hiroaki , Numata Shusuke , Ikeda Masashi , Ohnuma Tohru , Iwata Nakao , Ueno Shu‐ichi , Ozaki Norio , Ohmori Tetsuro , Arai Heii , Takeda Masatoshi 
Published: March 2012

AbstractGenome‐wide association and follow‐up studies have reported an association between schizophrenia and rs12807809 of the NRGN gene on chromosome 11q24.2. We investigated the association of five linkage disequilibrium‐tagging SNPs and haplotypes that cover the NRGN gene with schizophrenia in a Japanese sample of 2,019 schizophrenia patients and 2,574 controls to determine whether rs12807809 is the most strongly associated variant for schizophrenia in the vicinity of the NRGN gene. We found that the rs12807809–rs12278912 haplotype of the NRGN gene was associated with schizophrenia (global P = 0.0042). The frequencies of the TG and TA haplotypes of rs12807809–rs12278912 in patients were higher (OR = 1.14, P = 0.0019) and lower (OR = 0.85, P = 0.0053), respectively, than in the controls. We did not detect any evidence of association of schizophrenia with any SNPs; however, two nominal associations of rs12278912 (OR = 1.10, P = 0.057) and rs2075713 (OR = 1.10, P = 0.057) were observed. Furthermore, we detected an association between the rs12807809–rs12278912 haplotype and NRGN expression in immortalized lymphoblasts derived from 45 HapMap JPT subjects (z = 2.69, P = 0.007) and confirmed the association in immortalized lymphoblasts derived from 42 patients with schizophrenia and 44 healthy controls (z = 3.09, P = 0.002). The expression of the high‐risk TG haplotype was significantly lower than the protective TA haplotype. The expression was lower in patients with schizophrenia than in controls; however, this difference was not statistically significant. This study provides further evidence of the association of the NRGN gene with schizophrenia, and our results suggest that there is a link between the TG haplotype of rs12807809–rs12278912, decreased expression of NRGN and risk of developing schizophrenia. © 2012 Wiley Periodicals, Inc.
Assessing combinatorial strategies to multimerize libraries of single‐domain antibodies
Authors: Oliveira Soraia S. , Aires da Silva Frederico , Lourenco Sara , Freitas‐Vieira Acilino , Cunha Santos Ana Catarina , Goncalves Joao 
Published: March 2012

AbstractSingle‐domain antibodies (SDAs) are among the most studied and interesting antibody fragments. These molecules combine advantages of antibodies and small molecules. However, SDAs present a low efficiency of in vivo targeting because of their low binding avidity and fast clearance from blood circulation. Multimerization of SDA can overcome these drawbacks and increase their therapeutic potency. In this work, we developed and compared three strategies that allow construction of SDA dimers derived from rabbit light chains—PCR overlap, sticky PCR, and restriction/ligation. The restriction/ligation strategy proved to be the most efficient and feasible method to construct a successful library of SDA dimers. To further explore this technique, we constructed different libraries that differed in linker length between the two SDAs, and assessed its efficiency to deliver antigen‐specific SDA dimers. We efficiently increased both the molecular size and avidity of antibody fragments, increasing the possibility of these molecules to bind to their antigen. Therefore, this work describes efficient tools for therapeutic development of SDA dimers.
Immunological evaluation of predicted linear B‐cell epitopes of human CD20 antigen
Authors: Anbouhi Mahdi Habibi , Abolhassani Mohsen , Bouzari Saeid , Khanahmad Hossein , Aghasadeghi Mohammad Reza , Madadkar‐Sobhani Armin , Amanzadeh Amir , Behdani Mahdi , Shokrgozar Mohammad Ali 
Published: March 2012

AbstractThe importance of B‐lymphocyte‐restricted differentiation antigen Bp35 (CD20) as a target for immunotherapeutic depletion of B cells is irrefutable. Several anti‐human CD20 (anti‐hCD20) monoclonal antibodies are expressed at different stages of development. However, resistance to anti‐CD20 therapy has made the search for new alternatives imperative. Identification of B‐cell epitopes within hCD20 using in silico tools can provide new opportunities to develop monoclonal antibodies with different binding sites. Furthermore, identification of the relationship between amino acid sequences of predicted B‐cell epitopes and immune responses facilitates the determination of immunogenic regions of proteins by using their primary structure. Experimental evaluation of predicted linear B‐cell epitopes as candidate peptides and bioinformatics allows us to explore this relationship. In this study, we selected three candidate epitopes within the extra membrane loop of hCD20 with the aid of five immunoinformatics predictor web servers and evaluated mouse humoral response to keyhole‐limpet‐hemocyanin‐conjugated peptides, and P4 and P5 peptides (the extracellular loop of hCD20 without and with a disulfide bond, respectively). Injection of the peptides yielded results that confirmed the prediction and selection of candidates. ELISA and flow cytometry corroborated the in silico selections. The B‐cell epitopes P1, P2, and P3 were effective for immunization of mice.
Disruption of oligodendrocyte gap junctions in experimental autoimmune encephalomyelitis
Authors: Markoullis Kyriaki , Sargiannidou Irene , Gardner Christopher , Hadjisavvas Andreas , Reynolds Richard , Kleopa Kleopas A. 
Published: March 2012

AbstractGap junctions (GJs) are vital for oligodendrocyte survival and myelination. In order to examine how different stages of inflammatory demyelination affect oligodendrocyte GJs, we studied the expression of oligodendrocytic connexin32 (Cx32) and Cx47 and astrocytic Cx43 in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis (MS) induced by recombinant myelin oligodendrocyte glycoprotein. EAE was characterized by remissions and relapses with demyelination and axonal loss. Formation of GJ plaques was quantified in relation to the lesions and in normal appearing white matter (NAWM). During acute EAE at 14 days postimmunization (dpi) both Cx47 and Cx32 GJs were severely reduced within and around lesions but also in the NAWM. Cx47 was localized intracellularly in oligodendrocytes while protein levels remained unchanged, and this redistribution coincided with the loss of Cx43 GJs in astrocytes. Cx47 and Cx32 expression increased during remyelination at 28 dpi but decreased again at 50 dpi in the relapsing phase. Oligodendrocyte GJs remained reduced even in NAWM, despite increased formation of Cx43 GJs toward lesions indicating astrogliosis. EAE induced in Cx32 knockout mice resulted in an exacerbated clinical course with more demyelination and axonal loss compared with wild‐type EAE mice of the same backcross, despite similar degree of inflammation, and an overall milder loss of Cx47 and Cx43 GJs. Thus, EAE causes persistent impairment of both intra‐ and intercellular oligodendrocyte GJs even in the NAWM, which may be an important mechanism of MS progression. Furthermore, GJ deficient myelinated fibers appear more vulnerable to CNS inflammatory demyelination. © 2012 Wiley Periodicals, Inc.
A convenient method for electron tomography sample preparation using a focused ion beam
Authors: Wang Xiongyao , Lockwood Ross , Vick Doug , Li Peng , Meldrum Al , Malac Marek 
Published: March 2012

AbstractHere we report a new sample preparation method for three‐dimensional electron tomography. The method uses the standard film deposition and focused ion beam (FIB) methods to significantly reduce the problems arising from the projected sample thickness at high tilt angles. The method can be used to prepare tomography samples that can be imaged up to a ±75° tilt range which is sufficient for many practical applications. The method can minimize the problem of Ga+ contamination, as compared to the case of FIB preparation of rod‐shaped samples, and provides extended thin regions for standard 2D projection analyses. Microsc. Res. Tech. 75:1165–1169, 2012. © 2012 Wiley Periodicals, Inc.
Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats
Authors: McDonald Michelle M. , Morse Alyson , Mikulec Kathy , Peacock Lauren , Yu Nicole , Baldock Paul A. , Birke Oliver , Liu Min , Ke Hua Zhu , Little David G. 
Published: March 2012

AbstractRecent studies suggest a possible role for inhibitors of sclerostin such as sclerostin antibody (Scl‐Ab) as an anabolic treatment for osteoporosis. Since Scl‐Ab has also been shown to potentiate bone repair, we examined the effect of Scl‐Ab treatment in a metaphyseal defect repair model in ovariectomized (OVX) rats. Four weeks after OVX or sham surgery, 3 mm circular defects were created bilaterally in the proximal tibia of all rats. After defect surgery, Saline or 25 mg/kg Scl‐Ab was administered twice weekly for 3 weeks. Of note, healing was advanced in the 1‐week post‐defect surgery in OVX controls over Sham controls, with increases in bone volume and fluorochrome labeling observed. However, by week 2, OVX controls fell significantly behind in the repair response compared with Sham controls. Scl‐Ab treatment significantly increased bone volume in the defect in OVX rats over the 3‐week time course as examined by either microCT or histology. Significant increases in bone formation via fluorochrome labeling of the new bone were observed with Scl‐Ab treatment, while osteoclast parameters were not different. With its powerful anabolic potential, bone‐specific activity, and potential for low dosing frequency, Scl‐Ab treatment could provide enhanced bone repair, particularly in situations of compromised bone repair such as osteoporotic bone. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1541–1548, 2012
Surgical management of frontal sinus inverted papilloma: A systematic review
Authors: Walgama Evan , Ahn Chul , Batra Pete S. 
Published: March 2012

AbstractObjectives/Hypothesis:Surgical management of frontal sinus (FS) inverted papilloma (IP) remains a significant challenge. This study systematically reviews the FS IP literature to delineate outcomes based on surgical strategy.Study Design:Systematic review.Methods:Cases for inclusion were identified by literature query for the terms frontal sinus and inverted papilloma between 1995 and 2010. Cases reported with sufficient outcomes data, defined as specific surgical approach and disease‐free follow‐up, were included. Statistical analysis was performed to identify significant risk factors for recurrence. The reported length of follow‐up for each surgical approach was analyzed as an indicator of the strength of the reported literature for each approach.Results:Fifty‐seven cases were identified in 13 studies, with 49 cases deemed adequate for additional analysis. Twenty‐four cases (49%) were primary, and 25 (51%) were secondary (residual or recurrent disease) IP. Bilateral FS involvement was reported in eight cases (16.3%). Surgical approaches employed included endoscopic frontal sinusotomy (EFS) in 21 (42.9%), endoscopic modified Lothrop (EML) in 10 (20.4%), osteoplastic flap in 13 (26.5%), and endoscopic trephination and EFS in five (10.2%) patients. The overall rate of recurrence was 22.4%. Mean follow‐up time was 27 months.Conclusions:The recent reported literature of FS IP demonstrates high prevalence of recurrent and bilateral cases. Although statistical analysis of this accrued data is unable to delineate the best surgical approach for FS IP, more aggressive approaches frequently employed for secondary or bilateral disease may facilitate better disease control.
Mitogenic Activity of Sulfated Chitosan and Cellulose Derivatives is Related to Protection of FGF‐2 from Proteolytic Cleavage
Authors: Weltrowski Annett , da Silva Almeida Marie‐Luise , Peschel Dieter , Zhang Kai , Fischer Steffen , Groth Thomas 
Published: March 2012

AbstractNovel chitosan (CHS) and cellulose sulfates (CSs) are studied regarding their mitogenic activity and their protective effect against proteolytic digestion of FGF‐2. An intermediate degree of sulfation (DSS) and lower concentration of CHS have superior effect on 3T3 cell growth while the mitogenic activity of CS increases with DSS and concentration. Experiments with trypsin as model proteinase show that protection of FGF‐2 from proteolytic digestion depends on DSS and the concentration of derivatives in the same manner as cell growth. Studies on stability of FGF‐2 added to cultures of 3T3 cells show that the FGF‐2 concentration remains higher in the presence of derivatives. Results indicate that the mitogenic activity of CHS and CS is due to protection of FGF‐2 from proteolytic cleavage.magnified image