P5-S6.28 HIV prevention based on the static modes of transmission synthesis for two Indian districts: insights from dynamical modelling
Authors: Mishra S , Vickerman P , Pickles M , Ramesh B M , Washington R , Issac S , Moses S , Blanchard J , Boily M C 
Published: July 2011

BackgroundThe Modes of Transmission (MOT) synthesis uses a static HIV transmission model to predict distribution of incident infections along subgroups over 1 year, and directs HIV prevention along this distribution. Because the MOT does not consider where sustained transmission is most likely to occur, and does not use parameter combinations fitted to observed epidemic characteristics, its relevance for planning interventions may be limited.MethodsWe fitted a dynamical HIV/STI heterosexual transmission model to districts Mysore and Belgaum, India. The MOT and dynamical models estimated the proportion of new HIV infections over 1 year due to transmission between female sex workers/clients, their non-commercial partnerships, and low-risk partnerships. We compared predictions from the dynamical model to MOT results using prior and posterior (fitted) parameters. Intervention impact was illustrated using the dynamical model.ResultsUsing prior inputs, the MOT predicted that commercial sex accounted for 66.2–70.6% of incident infections among males, whereas 71.7–74.2% of incident infections among females were due to bridging infections from clients. There was less variability in MOT results when fitted inputs were used. The majority of the remaining new infections in males and females were due to transmission within low-risk partnerships. In contrast, the dynamical model predicted a higher contribution of commercial sex among males (90.7–91.2%), a higher contribution of bridging infections among females (70.5–86.9%), and that <1.5% of infections were due to low-risk partnerships. Dynamical modelling predicted that any intervention that reduces transmission by 20% applied among commercial sex partnerships could decrease overall HIV incidence by 12% in the first year and by 21% in 5 years see Abstract P5-S6.28 table 1. Applying this intervention among non-commercial partnerships of clients reduces overall incidence by 9% in years 1 through 5 because clients continue to become infected from their commercial partnerships.Abstract P5-S6.28 Table 1Distribution of 1-year incident infections by type of partnership, as predicted by the MOT and a fitted dynamical modelPartnership typeMedian % of incident infections attributable to partnership types (2.5 and 97.5 percentiles)MOT (prior inputs)MOT (posterior inputs)Dynamical modelMysoreBelgaumMysoreBelgaumMysoreBelgaumFemalesCommercial6.5 (2.4, 14.9)5.1 (1.9, 12.2)7.0 (3.3, 13.0)4.5 (2.0, 8.8)28.4 (18.6, 35.5)11.7 (5.7, 15.0)Main partnerships of FSWs/Clients71.7 (50.4, 88.7)74.2 (48.6, 90.9)75.6 (61.0, 87.8)73.0 (55.4, 84.9)70.5 (63.6, 80.3)86.9 (83.5, 92.9)Casual partnerships of FSWs/Clients0.03 (0.01, 0.09)0.01 (0.003, 0.04)0.02 (0.01, 0.07)0.01 (0.004, 0.04)0.30 (0.25, 0.38)0.31 (0.23, 0.38)Low-risk20.0 (4.6, 40.7)19.4 (4.3, 44.3)15.8 (7.1, 29.3)21.8 (10.9, 38.7)0.76 (0.31, 1.1)1.0 (0.61, 1.4)MalesCommercial70.6 (21.4, 92.6)66.2 (14.3, 92.8)66.0 (40.6, 81.1)69.1 (41.7, 84.3)91.2 (90.8, 95.6)90.7 (88.4, 96.1)Main partnerships of FSWs/Clients9.8 (3.4, 21.3)10.8 (3.6, 20.9)11.3 (6.1, 20.2)9.6 (4.2, 19.5)6.3 (3.4, 8.1)7.3 (2.9, 9.2)Casual partnerships of FSWs/Clients2.0 (0.5, 4.0)4.5 (1.2, 9.9)1.7 (0.66, 3.7)3.8 (1.3, 8.3)0.5 (0.3, 0.6)0.87 (0.51, 1.2)Low-risk15.6 (2.8, 58.5)13.0 (1.6, 65.8)19.7 (10.0, 36.9)14.9 (6.0, 35.4)0.6 (0.3, 0.9)1.0 (0.37, 1.4)FSW, female sex worker; MOT, Modes of Transmission.ConclusionPrior inputs for the MOT will not reflect observed HIV prevalence, and as a result, will produce greater variability in MOT predictions. Allocating resources along a 1-year distribution of incident infections can prioritise prevention to the wrong subgroups because they do not account for the dynamic effects of interventions. Improved methods of epidemic appraisals are urgently needed to guide prevention programming.