bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethanolic extract of Persea americana Mill. (Lauraceae) seeds induced antiestrogenic effects in young female Wistar rats
Authors: Minko Essono Stéphane , Mvondo Marie Alfrede , Wego Marius Trésor Kamgaing , Kemka Nguimatio François Xavier , Momo Tetsatsi Aimé Césaire , Watcho Pierre 
Published: April 2024

Abstract

Objectives
The ethanol extract of Persea americana seeds was found to inhibit the development of estrogen-dependent conditions in female Wistar rats, suggesting the ability of its secondary metabolites to interact with estrogen receptors (ERs), either as partial agonists or as antagonists. To test this hypothesis, the abovementioned extract was assessed for its ability to mimic and/or antagonize estradiol effects.

Methods
Two experiments were conducted in ovariectomized (OVX) rats: (1) animals were treated with estradiol valerate (E2V; 1 mg/kg) or P. americana at doses of 25 and 50 mg/kg; (2) animals were treated with E2V alone (0.75 mg/kg) or in combination with P. americana at the abovementioned doses. Treatments were given orally for 3 days and animals were sacrificed for biochemical and histological analyses of the uterus and vagina.

Results
When administered alone, P. americana did not change the histomorphology of both organs (uterus and vagina). In combination with E2V, P. americana decreased uterine weight [30 % decrease (p<0.001) at 25 mg/kg and 24 % (p<0.01) at 50 mg/kg] and epithelium height (37 % decrease). This was associated with decreased estradiol levels (at least 86 % decrease, p<0.001) in the uterus. Similarly, vagina epithelium height decreased by at least 34 % (p<0.05) when E2V was co-administered with P. americana.

Conclusions
The seed extract of P. americana contains ER antagonist secondary metabolites accounting for its ability to inhibit the development of estrogen-dependent conditions in female rats.
Measures of Lifespan Length and Variation Using a Mixture Model: The Case of Egypt
Authors: Siam Marwah S. , Sayed Hussein A. , El-Zeini Laila O. 
Published: April 2024

Abstract
Monitoring the changes in mortality patterns and levels requires studying mortality models and measures of lifespan length and variation. Measures of lifespan length and variation can be obtained from life tables or from mortality modes. In this paper, measures of lifespan length and variation are presented for mixture model introduced by Zanotto, L., V. Canudas-Romo, and S. Mazzuco. 2021. “A Mixture-Function Mortality Model: Illustration of the Evolution of Premature Mortality.” European Journal of Population 37 (1): 1–27. This was applied to the case of Egypt for males and females in the period 1950–2021. The mixture model was able to fit Egypt’s mortality pattern well for both males and females. The calculated measures of lifespan length and variation show that there is an increasing longevity and a declining variation of age at death distribution across time for both males and females.
Resistance Exercise Sessions Comprising Multijoint vs. Single-Joint Exercises Result in Similar Metabolic and Hormonal Responses, But Distinct Levels of Muscle Damage in Trained Men
Authors: Barbosa Paulo Henrique , Bueno de Camargo Julio Benvenutti , Jonas de Oliveira José , Reis Barbosa Carolina Gabriela , Santos da Silva Alexsandro , Dos-Santos Julio Wilson , Verlengia Rozângela , Barreira Júlia , Braz Tiago Volpi , Lopes Charles Ricardo 
Published: April 2024

Abstract
Barbosa, PH, Bueno de Camargo, JB, Jonas de Oliveira, J, Reis Barbosa, CG, Santos da Silva, A, Dos-Santos, JW, Verlengia, R, Barreira, J, Braz, TV, and Lopes, CR. Resistance exercise sessions comprising multijoint vs. single-joint exercises result in similar metabolic and hormonal responses, but distinct levels of muscle damage in trained men. J Strength Cond Res 38(5): 842–847, 2024—Resistance-type exercise (RE) elicits distinct acute metabolic and hormonal responses, which can be modulated by the manipulation of training variables. The purpose of this study was to compare the metabolic (blood lactate and estimated lactic anaerobic system energy expenditure) and hormonal (growth hormone [GH]) responses to RE sessions composed exclusively of multijoint (MULTI) or single-joint (SINGLE) exercises. Assessments of creatine kinase (CK) levels were also performed. In a crossover design, 10 recreationally resistance-trained men (age: 26.9 ± 3.0 years, total body mass: 83.2 ± 13.8 kg; height: 176 ± 7.0 cm; training experience: 5.5 ± 2.4 years) were randomly submitted to both protocols. Blood collections were made pre, 3 minutes after, and 36 hours after each experimental session. No significant difference between MULTI vs. SINGLE was observed for the rises in blood lactate (p = 0.057) and GH (p = 0.285) levels. For CK, a significant difference between the protocols was noted, in which MULTI resulted in significant rises after 3 minutes (p = 0.017) and 36 hours (p = 0.043) compared with SINGLE. In conclusion, the findings of this study suggest that resistance-trained individuals display similar metabolic and hormonal responses when performing MULTI and SINGLE exercise protocols. Also, RE sessions comprising MULTI exercises induce a higher magnitude of muscle damage, which may require a longer recovery period compared with SINGLE.
The Force-Vector Theory Supports Use of the Laterally Resisted Split Squat to Enhance Change of Direction
Authors: Cooley Chance , Simonson Shawn R. , Maddy Derek A. 
Published: April 2024

Abstract
Cooley, C, Simonson, SR, and Maddy, DA. The force-vector theory supports use of the laterally resisted split squat to enhance change of direction. J Strength Cond Res 38(5): 835–841, 2024—The purpose of this study was to challenge the conventional change of direction (COD) training methods of the modern-day strength and conditioning professional. A new iteration of the modified single-leg squat (MSLS), the laterally resisted split squat (LRSS), is theorized to be the most effective movement for enhancing COD performance. This study lays out a rationale for this hypothesis by biomechanically comparing the LRSS, bilateral back squat (BS), and MSLS with a COD task (90-degree turn). One repetition maximum (1RM) for LRSS, MSLS, and BS was measured for 23 healthy active female subjects. Peak ground reaction forces (GRF) for the dominant leg were recorded when performing COD and the LRSS, MSLS, and BS at 70% 1RM. Peak frontal plane GRF magnitude and angle were calculated for each task and submitted to repeated measures ANOVA. Peak GRF magnitude was significantly larger for COD (2.23 ± 0.62 body weight) than the LRSS, MSLS, and BS (p ≤ 0.001). Peak GRF angle was not significantly different between COD and the LRSS (p = 0.057), whereas the MSLS and BS (p < 0.001) vector angles were significantly greater than COD. In this application of the force-vector theory, the LRSS more closely matches COD than the MSLS or BS. Thus, the LRSS has the greater potential to enhance COD.
The Effects of Anchoring a Fatiguing Forearm Flexion Task to a High vs. Low Rating of Perceived Exertion on Torque and Neuromuscular Responses
Authors: Ortega Dolores G. , Housh Terry J. , Smith Robert W. , Arnett Jocelyn E. , Neltner Tyler J. , Schmidt Richard J. , Johnson Glen O. 
Published: April 2024

Abstract
Ortega, DG, Housh, TJ, Smith, RW, Arnett, JE, Neltner, TJ, Schmidt, RJ, and Johnson, GO. The effects of anchoring a fatiguing forearm flexion task to a high versus low rating of perceived exertion on torque and neuromuscular responses. J Strength Cond Res 38(5): e219–e225, 2024—This study examined the torque and neuromuscular responses following sustained, isometric, forearm flexion tasks anchored to 2 ratings of perceived exertion (RPE). Nine men (mean ± SD: age = 21.0 ± 2.4 years; height = 179.5 ± 5.1 cm; body mass = 79.6 ± 11.4 kg) completed maximal voluntary isometric contractions (MVIC) before and after sustained, isometric, forearm flexion tasks to failure anchored to RPE = 2 and RPE = 8. The amplitude (AMP) and mean power frequency (MPF) of the electromyographic (EMG) signal were recorded from the biceps brachii. Normalized torque was divided by normalized EMG AMP to calculate neuromuscular efficiency (NME). A dependent t-test was used to assess the mean difference for time to task failure (TTF). Repeated-measures analysis of variances was used to compare mean differences for MVIC and normalized neuromuscular parameters. There was no significant difference in TTF between RPE = 2 and RPE = 8 (p = 0.713). The MVIC decreased from pretest to posttest at RPE = 2 (p = 0.009) and RPE = 8 (p = 0.003), and posttest MVIC at RPE = 8 was less than that at RPE = 2 (p < 0.001). In addition, NME decreased from pretest to posttest (p = 0.008). There was no change in normalized EMG AMP or EMG MPF (p > 0.05). The current findings indicated that torque responses were intensity specific, but TTF and neuromuscular responses were not. Furthermore, normalized EMG AMP and EMG MPF remained unchanged but NME decreased, likely due to peripheral fatigue and excitation–contraction coupling failure. Thus, this study provides information regarding the neuromuscular responses and mechanisms of fatigue associated with tasks anchored to RPE, which adds to the foundational understanding of the relationship between resistance exercise and the perception of fatigue.
SIBERIAN SCIENTIST-BREEDER OF FRUIT AND BERRY CROPS VALENTINA NESTEROVNA VASILYEVA (on the 100th anniversary of her birth)
Authors: Доронькин В.М. , Горбунов А.Б. 
Published: April 2024

Статья приурочена к 100-летию со дня рождения Валентины Нестеровны Васильевой – ученого–селекционера семечковых и ягодных культур в Сибири.
The article is dedicated to the 100th anniversary of the birth of Valentina Nesterovna Vasilyeva, a scientist and breeder of pome and berry crops in Siberia.
Tobacco smoke adverse effects comparison based on gender: Meta-analysis
Authors: Worku Samuel 
Published: April 2024

Several studies have suggested varying degrees of vulnerability to the detrimental effects of tobacco smoking between females and males. However, conflicting findings on sex-specific differences in the negative impact of tobacco smoking have emerged. This study conducts a comprehensive review of the available evidence to assess the adverse effects of smoking with respect to gender. From an initial pool of 99 primary studies conducted before 2010, 26 studies were selected for inclusion in this meta-analysis. Among these, 15 were cohort studies, 4 were cross-sectional studies, 4 were case-control studies, and 2 were systematic reviews. Fixed-effect models and meta-regression were employed to derive pooled risk ratios (RR), and P-value functions were utilized to assess the consistency of the results. The pooled risk ratio for men who were current smokers, concerning all-cause mortality, was 0.954 (95% CI 0.866-1.05). For women who were current smokers, the pooled risk ratio for cardiovascular disorders was 1.2 (95% CI 1.18-1.22). Notably, female current smokers exhibited a significantly more rapid annual decline in FEV% predicted with increasing age compared to their male counterparts (as indicated by linear regression analysis: R2 = 0.56; p = 0.008). However, the relative risk for bone-related disorders was found to be higher in male current smokers than in their female counterparts. The findings of this study underscore that both males and females face an elevated risk of experiencing the adverse effects of smoking. Nonetheless, the magnitude of these effects differs based on gender. Further research is warranted to validate the outcomes of this study.
EDUCAÇÃO INCLUSIVA INCLUI? UM ESTUDO SOBRE A INCLUSÃO ESCOLAR NA EDUCAÇÃO BÁSICA DO MUNICIPIO DE PALHOÇA SOB A ÓTICA DE PROFESSORES DA EDUCAÇÃO ESPECIAL
Authors: De Andrade Bressan Jurema , Lazaretti Suelen 
Published: April 2024

Este estudo trata-se de uma pesquisa qualitativa que objetivou compreender o processo de inclusão escolar na educação básica do município de Palhoça na percepção dos professores da educação especial. Participaram da pesquisa quatro professores da educação especial no nível básico. Os resultados e discussão foram apresentados em três categorias: Perfil dos professores, Concepções acerca da inclusão escolar e Entraves do processo inclusivo. Assim, o estudo evidencia que a maioria dos professores pesquisados são do sexo feminino, atuam em dois turnos de trabalho e possuem formação que lhes permite atuar no processo inclusivo. A sobrecarga de trabalho desses profissionais é um dado que se mostrou evidente. Os professores possuem ciência de sua importância e papel no processo inclusivo, promovendo atividades que incluam de fato o estudante nas turmas e na comunidade escolar, sempre incentivando a autonomia e desenvolvimento de seus alunos. Os professores pesquisados percebem o processo inclusivo como um movimento de cidadania ao aluno da educação especial e o que ainda traz dificuldades a esse processo é a falta de conhecimento sobre o universo da educação inclusiva por parte de alguns profissionais e da comunidade escolar, bem como da família, o que acaba por dificultar o processo. Para atingir a efetividade no processo inclusivo, foi proposta uma formação continuada/ capacitação bem como a sensibilização da comunidade escolar em geral para que se saiba a importância e o impacto do processo inclusivo para o estudante, para a escola e para a sociedade em geral.
THE ROLE OF ENTREPRENEURSHIP EDUCATION IN UNIVERSITIES TO PURSUE SUSTAINABLE DEVELOPMENT GOALS
Authors: Patricia Patricia 
Published: April 2024

<p>Flourishing businesses, in contrast to those solely prioritizing profit, have greater potential for innovation, more opportunities, reduced risk, and enhanced resilience in our rapidly changing world. This paper outlines the critical intersection between entrepreneurship education (EE) and the pursuit of UN Sustainable Development Goals (SDGs) within higher education institutions. This paper examines how universities can leverage EE as a stimulant for advancing sustainable development initiatives and fostering a culture of responsible entrepreneurship among students. Drawing on existing literature, the paper explores the multifaceted contributions of EE to the SDGs across various domains, including poverty alleviation, gender equality, environmental sustainability, and economic growth. It highlights the role of EE in equipping students with the knowledge, skills, and mindset necessary to address complex social and environmental challenges through entrepreneurial endeavors. Furthermore, the paper identifies the strategies and best practices for integrating sustainability principles into EE curricula, emphasizing the importance of experiential learning, interdisciplinary collaboration, and community engagement. It also discusses the role of universities as hubs of innovation and research in developing solutions to pressing global issues and fostering entrepreneurial ecosystems that support sustainable development initiatives. Overall, the paper underscores the transformative potential of entrepreneurship education in universities to drive meaningful progress towards the achievement of SDGs. It provides insights and recommendations for educators and practitioners seeking to harness the power of entrepreneurship education to create positive social, environmental, and economic impacts in the pursuit of sustainable development.</p>
PENGARUH LINGKUNGAN RUMAH SAKIT SERTA KEPEMIMPINAN TRANSFORMASIONAL TERHADAP KINERJA TENAGA KESEHATAN DI RUMAH SAKIT XYZ DKI JAKARTA
Authors: Setiawan Iwan 
Published: April 2024

<p>The purpose of this study is to explain the influence of the hospital environment and transformational leadership on the performance of health workers (inpatient nurses). The phenomenon that occurs is the level of complaints of patients and families of patients over inpatient nurse services by 60% of 30 respondents to the exploration study. The quantitative study was applied in research at XYZ private hospital located in DKI Jakarta. The respondents were 160 inpatient nurses who had been permanent employees for more than two years. Data collection through questionnaire measuring tools with Likert scale 1 – 5. Data analysis applies the Structural Equaition Model and data processing with SmartPLS. The results show that the hospital environment, transformational leadership has a positive effect on the performance of health workers. Research contributions can be used as reference material for private hospitals to improve the performance of health workers.</p><p><strong>Bahasa Indonesia Abstrak:</strong> Tujuan penelitian ini ingin menjelaskan pengaruh dari lingkungan rumah sakit dan kepemimpinan transformasional terhadap kinerja tenaga kesehatan (perawat ruang rawat inap). Fenomena yang terjadi tingkat keluhan pasien dan keluarga pasien atas layanan perawat rawat inap sebesar 60% dari 30 orang responden studi eksplorasi. Studi kuantitatif diterapkan dalam penelitian di Rumah Sakit swasta XYZ yang berada di DKI Jakarta. Responden adalah 160 orang perawat ruang rawat inap yang sudah menjadi pegawai tetap lebih dari dua tahun. Pengumpulan data melalui alat ukur kuisioner dengan skala <em>likert </em>1 – 5. Analisis data menerapkan <em>Structural Equaition Model </em>dan<em> </em>pengolahan datanya dengan <em> SmartPLS</em>. Hasil menunjukkan bahwa lingkungan rumah sakit, kepemimpinan transformasional berpengaruh positif terhadap kinerja tenaga kesehatan. Kontribusi penelitian dapat dijadikan bahan referensi untuk rumah sakit swasta demi meningkatkan kinerja tenaga kesehatan</p>
KONFLIK SOSIAL DAN NILAI PENDIDIKAN KARAKTER DALAM NOVEL BUKU BESAR PEMINUM KOPI KARYA ANDREA HIRATA
Authors: Riyaningrum Latifah , Setiawan Budhi , Waluyo Budi 
Published: April 2024

<p>Penelitian ini bertujuan untuk mendeskripsikan konflik sosial dan nilai pendidikan karakter dalam novel <em>Buku Besar Peminum Kopi </em>karya Andrea Hirata. Penelitian ini merupakan penelitian deskriptif kualitatif dengan menggunakan pendekatan sosiologi sastra yang berfokus pada konflik sosial. Data penelitian ini adalah bagian-bagian atau kutipan novel yang bermatan konflik sosial. Yang menjadi sumber data adalah novel <em>Buku Besar Peminum Kopi </em>karya Andrea Hirata. Teknik pengambilan sampel menggunakan <em>purposive sampling</em>. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah analisis dokumen dan wawancara mendalam. Teknik validasi data yang digunakan adalah triangulasi teori dan triangulasi sumber data. Analisis data menggunakan teknik analisis mengalir. Hasil penelitian ini menunjukkan bahwa: (1) novel <em>Buku Besar Peminum Kopi </em>karya Andrea Hirata mengandung lima dari enam bentuk konflik sosial berdasarkan teori dari Georg Simmel, yaitu konflik pertandingan antagonistik, konflik mengenai prinsip-prinsip dasar (kepentingan), konflik antarpribadi, konflik dalam hubungan intim atau akrab, dan konflik untuk menghancurkan kelompok. Konflik sosial yang paling dominan adalah konflik pertandingan antagonistik, sedangkan konflik hukum tidak ditemukan dalam novel tersebut; dan (2) novel <em>B</em><em>uku Besar Peminum Kopi </em>karya Andrea Hirata mengandung sembilan pilar pendidikan karakter berdasarkan teori dari Suparlan, yaitu tanggung jawab, rasa hormat, keadilan, keberanian, kejujuran, kewarganegaraan, disiplin diri, peduli, dan ketekunan. Nilai pendidikan karakter yang paling dominan yaitu nilai keberanian dan tanggung jawab. Nilai tersebut ditunjukkan oleh para tokoh melalui ucapan maupun tindakan secara langsung.</p>
PENGARUH METODE CIRC BERBASIS APLIKASI ROMAN TERHADAP KEMAMPUAN MENULIS CERPEN SISWA SMP
Authors: Hanifah Dwiana Nur Rizki , Sumarwati Sumarwati , Suhita Raheni 
Published: April 2024

<p>Kemampuan menulis cerita pendek siswa dipengaruhi oleh kurangnya minat siswa dalam belajar, minimnya penguasaan kosa kata, maupun kesulitan dalam memilih diksi yang tepat. Penelitian ini bertujuan untuk menguji (1) pengaruh penerapan model pembelajaran CIRC terhadap kemampuan menulis cerpen, (2) pengaruh penggunaan aplikasi Roman terhadap kemampuan menulis cerpen, (3) mengetahui interaksi pengaruh penggunaan model CIRC dan aplikasi Roman terhadap kemampuan menulis cerpen siswa SMP. Penelitian ini merupakan penelitian eksperimen semu. Teknik pengambilan sampel dilakukan melalui <em>purposive sampling. </em>Hasil penelitian ini adalah sebagai berikut. <em>Pertama, </em>terdapat pengaruh penerapan model pembelajaran CIRC terhadap kemampuan menulis cerpen siswa. <em>Kedua, </em>tidak ada pengaruh penggunaan Aplikasi Roman terhadap kemampuan menulis cerpen siswa. <em>Ketiga, </em>tidak ada interaksi pengaruh penggunaan model CIRC dan Aplikasi Roman terhadap kemampuan menulis cerpen siswa.</p>
PEMBINGKAIAN BERITA PADA KOMPAS.COM TERHADAP KASUS PELECEHAN SEKSUAL DI PONDOK PESANTREN SHIDDIQIYYAH, JOMBANG
Authors: Fatinova Dede , Hapsari Natalia Endah 
Published: April 2024

<span class="s6">Salah satu berita yang mendapat banyak perhatian warga Indonesia adalah kasus pelecehan seksual terhadap </span><span class="s6">santriwati oleh</span><span class="s6"> putra pengelola di Pesantren Shiddiqiyyah, Kabupaten Jombang. Media Kompas.com merupakan salah satu media yang konsisten memberitakan kasus tersebut. Penelitian ini bertujuan untuk mendeksripsikan bagaimana pembingkaian wacana tentang pemberitaan kasus itu pada media massa Kompas.com. Teori pembingkaian</span><span class="s6"> </span><span class="s6">yang diterapakan dalah </span><span class="s6">model Zhongdang Pan dan Gerald M. </span><span class="s6">Kosicki </span><span class="s6">melalui</span><span class="s6"> empat perangkat analisis, yaitu sintaksis, skrip, tematik, dan retoris. Metode penelitian ini adalah deskriptif kualitatif dengan pendekatan analisis wacana kritis. Unit analisis atau sumber data adalah tiga teks berita yang relevan dengan topik penelitian di media Kompas.com sehingga pemilihannya menerapkan purposive sampling. Pengumpulan </span><span class="s6">data dilakukan</span><span class="s6"> dengan menggunakan analisis dokumen. Hasil penelitian menunjukkan bahwa pembingkaian yang dilakukan Kompas.com memiliki tendensi untuk memunculkan citra negatif pada pengelola pondok pesantren dan profesi ustaz. Hal ini disebabkan dalam pemberitaannya Kompas lebih menekankan profesi ustaz dibandingkan </span><span class="s6">personal pelaku</span><span class="s6"> kejahatan seksual.</span>