bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Patients' Sera with Sperm‐Immobilizing Antibodies on Sperm of the Japanese Monkey
Authors: Kameda Kinu , Fukuda Hiroshi , Shigeta Minoru , Tsuji Yoshiyuki , Koyama Koji , Torii Ryuzo , Isojima Shinzo 
Published: August 2010

AbstractIn order to study the interspecies cross‐reactivity of sperm‐immobilizing antibodies found in sera of women who were infertile for unknown reasons, we used the sperm‐immobilization test to examine the effects of patients' sera with or without sperm‐immobilizing antibodies on the sperm of the Japanese monkey (Macaca fuscata).Fourteen of 17 antibody‐positive sera and 7 of 14 antibody‐negative sera showed sperm‐immobilizing activity with regard to monkey sperm. The sperm‐immobilizing antibody that was active against both human and monkey sperm could be absorbed only by sperm from each corresponding species. The periodate treatment of human or monkey sperm markedly diminished their antibody‐absorbing capabilities. Human and mouse monoclonal antibodies having sperm‐immobilizing activity with regard to human sperm showed no sperm‐immobilizing activity with regard to monkey sperm.These results indicate that the sperm‐immobilizing activity of the sera of infertile women against human and monkey sperm might be due to antibodies with different specificities, which recognize a unique carbohydrate antigen epitope expressed in the sperm of each species.
Feticide Followed by Successful Removal of Pregnancy Products in Early Abdominal Pregnancy
Authors: Qureshi Rahat N. , Chaudhuary Nasreen , Rizvi Imtiaz , Afzal Masood 
Published: August 2010

AbstractPatient presented with an acute abdomen at 18 weeks gestation. Ultrasound and CT scan confirmed single extra uterine gestation. Considering the maternal hazards associated with surgical removal of viable abdominal pregnancy feticide was performed with ultrasound guided intracardial injection of KCl solution. Ten days after the procedure successful removal of pregnancy was achieved with no intra or post operative complications.
Prediction of First‐Trimester Miscarriage from Embryonic Bradycardia and Embryonic Growth Delay
Authors: Ikegawa Akira 
Published: August 2010

AbstractObjective: The purpose of this study was to determine whether subsequent and simultaneous measurements of embryonic heart rate (EHR) and crown‐rump length (CRL) are useful in predicting miscarriage.Study Design: A prospective cross‐sectional study was performed on miscarriages with detectable embryonic heart rate (n = 33). Chromosomal tests were carried out in 9 of 33 cases.Result: In cases with embryonic bradycardia and/or embryonic growth delay, the mean CRL was 6.6 mm (n = 16), and embryonic death occurred at CRL values under 20 mm. In cases where neither bradycardia nor growth delay was detected, the CRL was 23.9 mm (n = 17) at embryonic death. Chromosomal abnormalities were present as triploidy (n = 5) and trisomy‐16 (n = 2) in both bradycardia and embryonic‐growth‐delay cases.Conclusion: Subsequent and simultaneous measurements of EHR and CRL are useful in predicting miscarriage in the first trimester, especially when the CRL is under 20 mm.
Prevalence, Genotypes and Antibody Titer of Hepatitis C Virus in Pregnant Women in Taiwan
Authors: Lin Ho‐Hsiung , Kao Jia‐Horng , Huang Su‐Cheng , Lee Tzu‐Yao , Chen Pei‐Jer , Chen Ding‐Shinn 
Published: August 2010

AbstractObjectives: To investigate the prevalence and genotypes of hepatitis C virus (HCV) in pregnant women in Taiwan, as well as to examine whether any correlation occurs between HCV genotype and anti‐HCV titer.Methods: Forty‐three pregnant women with positive anti‐HCV and HCV‐ RNA were selected among 3,400 cases screened from January 1992 to March 1994. Each blood specimen was assayed for HCV genotypes by PCR method to detect HCV I, II, III and IV. Anti‐HCV titer was determined by a second‐generation EIA kit with serial dilutions.Results: Twenty‐eight cases (65%) belonged to HCV II, 11 (26%) HCV III, 3 (7%) HCV IV and 1(2%) HCV II+III. Besides, the anti‐HCV titers in HCV II and HCV III groups were similar, ranging from 8x to 40,000x and revealing no statistical significance (p = 0.75).Conclusions: Our data have verified that the prevalence rate of HCV infection in pregnant women is around 1.3% and no significant difference of anti‐HCV titer occurs between HCV II and HCV III pregnant women.
Clinical Usefulness of the Dye‐Injection Method for Diagnosing Premature Rupture of the Membranes in Equivocal Cases
Authors: Fujimoto Seiichiro , Kishida Tatsuro , Sagawa Tadashi , Negishi Hiroaki , Okuyama Kazuhiko , Hareyama Hitoshi , Makinoda Satoru 
Published: August 2010

AbstractObjective: In 1981, we preliminarily reported on the clinical value and safety of the intra‐amniotic dye (Phenol‐sulfonphthalein, PSP)‐injection method for diagnosing PROM. In the current study, through examination of 64 equivocal cases in the midtrimester of pregnancy, we investigated the clinical efficacy of the PSP test.Methods: In the present study we examined patients with equivocal PROM in their 14th week to 33rd week of gestation, whose findings were positive according to a combination of conventional diagnostic methods. The results of the PSP test and conventional diagnostic methods were compared with the final diagnosis of PROM.Results: The conventional diagnostic methods showed an accuracy rate of 63.9%–70.5%, in contrast to the PSP test, which had a 100%‐accuracy rate (p < 0.001).Conclusion: Using the PSP test in combination with amnioscopy, we have established a method of differentially diagnosing PROM. We have reconfirmed the clinical efficacy of the PSP test in 64 equivocal PROM cases.
Effect of Bronchial Asthma on the Course of Pregnancy, Labour and Perinatal Outcome
Authors: Jana Narayan , Vasishta Kala , Saha Subhas C. , Khunnu Bhawani 
Published: August 2010

AbstractThe course of pregnancy and labour, and perinatal outcome of 182 pregnancies complicated by bronchial asthma, over a 10‐year period were studied. Antiasthmatic medications included oral and/or parenteral β2‐agonists, theophylline, aminophylline, corticosteroids, and inhaled salbutamol and beclomethasone. A control group of 364 nonasthmatic gravidas was matched for age and parity.In asthmatic gravidas, antenatal complications mean duration of pregnancy (38.5 weeks), mode of delivery, incidence of prematurity (13.2%) and low birth weight (LBW, 19.6%) and perinatal mortality (0.5%) were not significantly different compared to the controls (p > 0.05). However, uncontrolled severe asthma in 15 gravidas who required hospitalization, was associated with significant decrease in mean birth weight (2469 ± 571 g vs 2842 ± 494 g; p < 0.05) and a high incidence of LBW neonates (53.3% vs 20.5%; p < 0.01) at mean gestation of 38 weeks.Bronchial asthma during pregnancy, when optimally controlled does not affect the course or pregnancy and labour, and perinatal outcome. However, uncontrolled severe asthma leads to fetal growth retardation.
Malignant Brenner Tumor of the Ovary: Two Cases of Unusual Histologic Features of Relapsed Tumors
Authors: Kataoka Akio , Nishida Takashi , Imaishi Kiyohisa , Sugiyama Toru , Yakushiji Michiaki 
Published: August 2010

AbstractThis study focused on unusual histologic features observed in 2 relapsed Brenner tumors. Case 1: A 67‐year‐old woman had a malignant Brenner tumor. The tumor relapsed was squamous‐cell carcinoma. Case 2: A 51‐year‐old woman had a proliferating and malignant Brenner tumor with mucinous metaplasia. The relapsed tumor was a well‐differentiated mucinous adenocarcinoma. These cases suggest that: (1) the relapsed tumor cells survived chemotherapy; and (2) the relapsed tumor cells transformed.
A Clinical Trial on Diagnostic Scoring System of Choriocarcinoma and Invasive Mole in Vietnam
Authors: Hoa Phan Trung , Phuong Nguyen Thi Ngoc , van Quyen Phan 
Published: August 2010

AbstractObjectives: The aim was to discrimate preoperatively invasive mole (IM) and choriocarcinoma (CC) in patients with gestational trophoblastic neoplasm (GTN) for early and satisfactory treatment in Vietnam.Methods: In 1990, 122 patients with GTN treated at TUDU Hospital were retrospectively analysed to make a differential diagnosis between CC and IM by using the JSOG scoring system and these results were later compared with postoperative histopathological findings. Furthermore, to raise the predictive diagnostic value for CC, the authors modified the JSOG system and devised a scoring system of TUDU hospital which results were compared with that of the JSOG ones.From the end of 1990 to March 1993, in 151 patients with GTN who underwent surgery, preoperative and postoperative diagnoses of CC and IM were prospectively compared using the JSOG and the modified scoring system.The comparative data were statistically analysed using the t‐test, X2 test and Fisher test. The sensitivity, specificity, and the positive and negative predictive value, and false positive and false negative were calculated and compared.ResultsRetrospective study: In making a predictive diagnosis of 122 patients with findings of trophoblastic tumors, the authors found some differences in possibility of CC of the following subfactors: latent period, primary lesion, pulmonary metastases, metastases except pulmonary metastases and hCG rerise. So, a modified scoring system of TUDU hospital was devised.Prospective study: Of 151 Vietnamese patients with GTN using the JSOG scoring system and the modified system, a diagnostic probability in 108 cases predicted choriocarcinoma by JSOG scoring system was 61%, while that of invasive mole in 43 cases was 62.8%. Accordingly, the false positive rate for invasive mole of 64 cases predicted choriocarcinoma was 38.9%. According to the modified scoring system, of 75 patients predicted choriocarcinoma, 69 patients were histologically confirmed choriocarcinoma. Therefore, the diagnostic specificity was high (94.20%) and the false positive rate was low (5.3%), while of 76 patients predicted invasive mole, 13 patients were histologically diagnosed as choriocarcinoma. Accordingly, the false negative rate was low (13.1%).Conclusion: The modified JSOG scoring system is of more diagnostic value in the preoperative differentiation between CC and IM in Vietnam.
Familial Risk Factors for a Second Primary Malignancy in Endometrial or Ovarian Carcinoma
Authors: Shiromizu Kenji , Araki Joji , Onda Takashi , Nishimura Toshinobu , Takahashi Michiko , Matsuzawa Masumi 
Published: August 2010

AbstractObjective: To elucidate the risk factor for a second primary carcinogenesis in endometrial or ovarian carcinoma patients.Methods: Endometrial and ovarian carcinoma patients treated from 1975 through 1990 were analyzed clinicopathologically.Results: The incidence of patients with a second primary malignancy was 10.5% (28/267) in endometrial carcinoma cases, and 9.0% (13/144) in ovarian carcinoma cases. Endometrial carcinoma patients whose parents, siblings, and/or children had developed malignant diseases were at risk for a second primary malignancy. This familial factor is also believed to be a risk factor for ovarian carcinoma patients, but the results lacked statistical significance. There also was no statistical significance with respect to smoking and/or alcohol consumption. More than one‐half of the second primary carcinomas were breast, colon, or stomach carcinomas.Conclusions: Cancer patients with this familial high‐risk factor should be carefully and regularly followed up by monitoring at every anatomic site, especially the breast, stomach, and colon, in order that the development of a second primary carcinoma can be detected as early as possible, and not be overlooked in examinations.
Tissue Expression of Sialyl Tn Antigen in Gynecologic Tumors
Authors: Numa Fumitaka , Tsunaga Nagato , Michioka Toru , Nawata Shugo , Ogata Hidenobu , Kato Hiroshi 
Published: August 2010

AbstractObjective(s): To investigate tissue expression of Sialyl Tn antigen (STN) in gynecologic tumors, and to compare with its appearance in blood circulation.Methods: Surgical specimens were obtained from 24 patients with malignant gynecologic diseases, including 7 ovarian cancers, 13 cervical cancers, 3 endometrial cancers, and 1 vulval cancer. Control tissues were also obtained at surgery from 28 patients with benign tumors of the ovary or uterus.Results: Anti‐STN monoclonal antibody (TKH‐2) positively identified 6 (86%) of 7 ovarian cancers, 11 (85%) of 13 cervical squamous‐cell carcinomas, but none of 3 endometrial cancers. None of the 28 benign tissues, including 11 ovarian benign tumors, showed positive immunostaining for STN, except 1 with an ovarian chocolate cyst which showed weak staining for STN. No expression was found in normal squamous epithelium distant from the lesion. Serum STN antigen was positive in 4 of 7 ovarian cancers (cutoff = 39 U/ml), but only in 2 of 13 cervical cancers, and none in the 3 endometrial cancers.Conclusion(s): These findings indicate different behaviors in the appearance of STN in tumor tissue and blood circulation, and also suggest the possible applicability of STN to immunohistochemical diagnosis of squamous‐cell carcinomas.
Maternal and Perinatal Mortality/Morbidity Associated with Cesarean Section in Indonesia
Authors: Wirakusumah Firman F. 
Published: August 2010

AbstractObjectives: To compare the frequencies of maternal mortality and perinatal mortality, and severe morbidity among cases of cesarean delivery.Study Design: A cohort study, the outcome of major interest (cesarean section) being evaluated retrospectively and the cohort being hospital‐based and actually covering a 10‐year period.Subjects: Six hundred sixty‐three cesarean deliveries out of a total of 7,128 births in the period 1981–1983 and 761 out of 8,534 in 1988–1990 were analyzed.Statistical Analysis: Chi‐square statistical analysis and Linear regression analysis were used.Results: The maternal mortality was 985.7/100,000 live births and 757.5/100,000 live births in period I and II, respectively. Perinatal mortality in the two periods was 125.6 per 1,000 live births and 90.8 per 1,000 live births, respectively. Although the cesarean birth rate did not increase, there was a decrease in maternal and perinatal mortality.The study demonstrated that although overall maternal mortality was high, the fatality rate in cesarean delivery was low: 4.5 and 2.6 per 1,000 cesarean sections in period I and II, respectively.Conclusions: Maternal mortality and perinatal mortality following cesarean delivery were more related to maternal illness rather than the surgery.
Urokinase‐Type Plasminogen Activator (uPA) and Its Receptor (CD87): A New Target in Tumor Invasion and Metastasis
Authors: Schmitt Manfred , Wilhelm Olaf , Jänicke Fritz , Magdolen Viktor , Reuning Ute , Ohi Hidekazu , Moniwa Nobuhiko , Kobayashi Hiroshi , Weidle Ulrich , Graeff Henner 
Published: August 2010

AbstractExtravasation and intravasation of tumor cells in solid malignant tumors is controlled by 3 steps: 1) attachment to and interaction of tumor cells with components of the basement membrane and the extracellular matrix, 2) local proteolysis, and 3) tumor cell migration. Evidence has accumulated that different types of tumor‐associated proteases, their inhibitors and receptors are involved in tumor invasion and metastasis. Four different classes of proteases are known to be correlated with the malignant phenotype: 1) Matrix metalloproteases; including collagenases, gelatinases and stromelysins. 2) Cysteine proteases; including cathepsins B and L. 3) Aspartyl protease cathepsin D. 4) Serine proteases; including plasmin and tissue‐type plasminogen activator (tPA) and urokinase‐type plasminogen activator (uPA). A strong independent prognostic value (relapse‐free and/or overall survival) has especially been demonstrated for uPA and its inhibitor PAI‐1 in patients with cancer of the breast, ovary, stomach, esophagus, colon, lung, and kidney thus predicting the course of the cancer disease. The strong correlation between elevated uPA and/or PAI‐I values in primary cancer tissues and the malignant phenotype of cancer cells has prompted to explore new tumor biology‐oriented concepts in order to suppress uPA or uPA receptor (CD87) expression or to abrogate interaction of uPA with CD87. Various very different approaches to interfere with the expression or reactivity of uPA or CD87 at the gene or protein level were successfully tested including antisense oligonucleotides, antibodies, inhibitors and recombinant or synthetic uPA and CD87 analogues.
The Imbalance of Plasminogen Activators and Inhibitor in Preeclampsia
Authors: Gao Meiyang , Nakabayashi Masao , Sakura Mari , Takeda Yoshihiko 
Published: August 2010

AbstractObjective: To evaluate the role of plasminogen activators (tPA uPA) and inhibitor (PAI‐1) in the pathogenesis of preeclampsia.Study Design: tPA uPA and PAI‐1 antigens were measured in amniotic fluid, maternal plasma, and placental homogenates in normal pregnancy by ELISA method and compared with that of preeclampsia.Results: In normal pregnancy, tPA, uPA and PAI‐1 levels increase as the gestation advance, but the increment of PAI‐1 in amniotic fluid (28.3‐fold) is larger than that of tPA and uPA (1.8‐fold, 8.5‐fold) (p < 0.001). Decidua homogenates contained larger amount of PAI‐1 than villi. Whereas, villi had higher levels of tPA uPA than decidua (p < 0.01). In preeclampsia, the significantly higher levels of PAI‐1 were observed in AF and decidua tissue as compared to the normals (p < 0.01), and the increment of PAI‐1 in preeclampsia is larger than that of tPA, uPA.Conclusions: The elevated PAI‐1 level is associated with the preeclampsia and the imbalance between the plasminogen activators (tPA, uPA) and the inhibitor (PAI‐1) might be involved in the pathogenesis of preeclampsia.
Clinical Utility of Calculated Creatinine Clearance as a Guide to Chemotherapy in Patients with Gynecologic Malignancies*
Authors: Kang Soon‐Boem , Kim Byoung‐Gie , Song Yong‐Sang , Lee Hyo‐Pyo 
Published: August 2010

AbstractObjective: To examine the relationship between calculated and measured creatinine clearance, and also to evaluate the clinical utility of calculated creatinine clearance before administration of chemotherapy in patients with gynecologic malignancies.Methods: In 38 patients with gynecologic malignancies, a total‐69 paired creatinine clearance measured by 24‐hour urinary creatinine clearance and calculated were compared.Results: The significant correlation (r = 0.597, p < 0.0001) was observed between creatinine clearances determined by both methods. There were 26 (37.7%) 24‐hour urine collections. The correlation between two methods improved when these inaccurate samples were excluded (r = 0.876, p < 0.0001). In addition, if a creatinine clearance of 50 ml/min is set as a threshold for dose modification, only 2.9% of the patients would have received reduced doses inappropriately, by using the calculated creatinine clearance alone.Conclusion: These results suggest that in patients with gynecologic malignancies, a calculated creatinine clearance prior to chemotherapy is sufficient for evaluation of renal function and measured creatinine clearance would be determined only when calculated creatinine clearance is below the threshold for dose modification.
Short Protocol of Gonadotropin Releasing Hormone Agonist Administration Gave Better Results in Long Protocol Poor‐Responders in IVF‐ET
Authors: Tašdemir Murat , Tašdemir Išik , Kodama Hideya , Fukuda June , Tanaka Toshinobu 
Published: August 2010

AbstractObjective: To determine the effectiveness of a short protocol (SP) of gonadotropin‐releasing hormone agonist (GnRH‐a) administration in patients who already had undergone at least one in vitro fertilization (IVF) and embryo transfer (ET) treatment cycle with the long protocol (LP) and had shown poor results.Methods: One hundred and twelve patients were studied. The E2 levels, the number of preovulatory follicles, the number of oocytes retrieved and fertilized, the number of embryos cleaved, the fertilization rate and the number of embryos transferred were calculated.Results: The values for the mentioned parameters were significantly higher in the SP than those in the LP. So were the pregnancy rates per cycle and per ET (23.2% and 24.1%, respectively) in the SP significantly (p < 0.0001) higher than those in the LP (12.5% and 13.5%, respectively).Conclusion: In cases who showed poor results to the LP, instead of repeating the same protocol the SP may be substituted. This strategy may not only improve the results, but also decrease the total cost of the IVF‐ET treatment.
Spontaneous Rupture of the Uterus Due to Placenta Percreta at 25‐Weeks' Gestation: A Case Report
Authors: Kinoshita Toshihiko , Ogawa Keigo , Yasumizu Takehiko , Kato Junzo 
Published: August 2010

AbstractPlacenta percreta is a rare but serious complication of pregnancy, and is rarely diagnosed in the second trimester of pregnancy. We report a very rare case of placenta percreta accompanied by spontaneous uterine rupture at 25‐weeks of gestation.A 30‐year‐old woman with severe abdominal pain was admitted to our hospital at 25 weeks of gestation. A laparotomy was immediately performed because of intraabdominal bleeding. The uterus revealed a perforation of the fundus. A supra‐vaginal hysterectomy was performed. A pathological investigation of the uterus revealed placenta percreta.The patient had neither gravity nor any prior uterine operation. It is very rare for placenta percreta to be recognized in a primigravida woman or in the second trimester of pregnancy.
Mother‐to‐Infant Transmission of Hepatitis C Virus in Human Immunodeficiency Virus‐Coinfected Mother: A Case Report
Authors: Koseki Satoshi , Taga Michiyoshi , Aoyama Mika , Hirabuki Tomoo , Hirahara Fumiki , Takahasi Tsuneo , Minaguchi Hiroshi , Yokota Shumpei , Ito Akira 
Published: August 2010

AbstractWe report a case of vertical transmission of HCV in a mother infected with both HCV and HIV. Our case suggests that coinfection with HIV, by causing an immune dysfunction, might be one of the risk factors for the transmission of HCV.
Comparison of the 50 g Capillary Plasma Glucose Tolerance Test with the 75 g Venous Plasma Glucose Tolerance Test in Pregnancy
Authors: Henry Olivia A. , Shelley‐Jones David C. , Oats Jeremy N. , Wein Peter , Beischer Norman A. 
Published: August 2010

AbstractObjective: To compare the 50 g oral glucose tolerance test with capillary sampling used in the Mercy Hospital for Women, Melbourne with the 75 g test with venous sampling advocated by the Australasian Diabetes in Pregnancy Society.Methods: Both the 50 g and 75 g glucose tolerance tests were performed on 60 women. Criteria for diagnosing gestational diabetes were the combination of a 1‐hour capillary plasma glucose ≥ 9 mmol/l and a 2‐hour glucose ≥ 7 mmoll for the 50 g test and a fasting glucose ≥ 5.5 mmol/l and/or a 2‐hour venous plasma glucose ≥ 8.0 mmol/l for the 75 g test.Results: Twenty‐eight of 60 women had gestational diabetes diagnosed with the 50 g test; 24 of these, and an additional 5 had gestational diabetes diagnosed on the 75 g test. Twenty‐seven women had normal results on both tests. The kappa statistic was 0.70. The 1‐hour glucose value was similar for both tests, but the 2‐hour value was significantly higher for the 75 g test (mean difference 0.65 mmol/l, 95% confidence limits 0.24–1.01 mmol/l, p = 0.003). The area under the curve was similar for the 2 tests.Conclusions: The 2 tests diagnose similar women as having gestational diabetes. The combination of a 75 g load and venous sampling gives similar 1‐hour but higher 2‐hour values than a 50 g load and capillary sampling.