bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sumatriptan Inhibits TRPV1 Channels in Trigeminal Neurons
Authors: Evans Miles Steven , Cheng Xiangying , Jeffry Joseph A. , Disney Kimberly E. , Premkumar Louis S. 
Published: January 2012

(Headache 2012;52:773‐784)Objective.— To understand a possible role for transient potential receptor vanilloid 1 (TRPV1) ion channels in sumatriptan relief of pain mediated by trigeminal nociceptors.Background.— TRPV1 channels are expressed in small nociceptive sensory neurons. In dorsal root ganglia, TRPV1‐containing nociceptors mediate certain types of inflammatory pain. Neurogenic inflammation of cerebral dura and blood vessels in the trigeminal nociceptive system is thought to be important in migraine pain, but the ion channels important in transducing migraine pain are not known. Sumatriptan is an agent effective in treatment of migraine and cluster headache. We hypothesized that sumatriptan might modulate activity of TRPV1 channels found in the trigeminal nociceptive system.Methods.— We used immunohistochemistry to detect the presence of TRPV1 channel protein, whole‐cell recording in acutely dissociated trigeminal ganglia (TG) to detect functionality of TRPV1 channels, and whole‐cell recording in trigeminal nucleus caudalis (TNC) to detect effects on release of neurotransmitters from trigeminal neurons onto second order sensory neurons. Effects specifically on TG neurons that project to cerebral dura were assessed by labeling dural nociceptors with DiI.Results.— Immunohistochemistry demonstrated that TRPV1 channels are present in cerebral dura, in trigeminal ganglion, and in the TNC. Capsaicin, a TRPV1 agonist, produced depolarization and repetitive action potential firing in current clamp recordings, and large inward currents in voltage clamp recordings from acutely dissociated TG neurons, demonstrating that TRPV1 channels are functional in trigeminal neurons. Capsaicin increased spontaneous excitatory postsynaptic currents in neurons of layer II in TNC slices, showing that these channels have a physiological effect on central synaptic transmission. Sumatriptan (10 µM), a selective antimigraine drug, inhibited TRPV1‐mediated inward currents in TG and capsaicin‐elicited spontaneous excitatory postsynaptic currents in TNC slices. The same effects of capsaicin and sumatriptan were found in acutely dissociated DiI‐labeled TG neurons innervating cerebral dura.Conclusion.— Our results build on previous work indicating that TRPV1 channels in trigeminal nociceptors play a role in craniofacial pain. Our findings that TRPV1 is inhibited by the specific antimigraine drug sumatriptan, and that TRPV1 channels are functional in neurons projecting to cerebral dura suggests a specific role for these channels in migraine or cluster headache.
Characteristics, Services, and Infection Control Practices of New York City Assisted Living Facilities, 2010
Authors: Stachel Anna G. , Bornschlegel Katherine , Balter Sharon 
Published: January 2012

ObjectivesTo describe New York City (NYC) assisted living facility (ALF) characteristics, services offered, and infection control practices and to identify infection control barriers and unmet needs.DesignCross‐sectional.SettingALFs licensed or applying to be licensed in NYC.ParticipantsSeventy ALFs; 70 of 77 eligible facilities participated (91% participation rate).MeasurementsTelephone interview questions assessed ALF characteristics, services offered, and infection control practices, including glucometry practices.ResultsALFs provided a broad range of services, such as vaccination (90%), assistance with taking medication (75%), bathing and showering (33%), and blood glucose monitoring (90%). Ninety percent of the facilities had nurses on site (directly employed or through a contract agency). Five facilities reported that residents sometimes shared glucometers, and one reported that fingerstick devices were sometimes shared. The majority of facilities wanted educational materials for staff (83%) and residents (77%) on topics including influenza, respiratory illness, norovirus, standard precautions, and general infection control. ALFs had a range of sick leave policies and infection control training requirements. Eighty‐nine percent of the facilities reported having designated staff responsible for infection control, although 50% had nonclinical job titles.ConclusionNYC ALFs were varied in terms of nursing services offered, characteristics, and residents’ needs; therefore, public health agencies may need to be flexible in their assistance. Public health agencies should consider strengthening relationships with ALFs to identify unmet needs and gaps in services.
Effects of a Late‐Life Suicide Risk–Assessment Training on Multidisciplinary Healthcare Providers
Authors: Huh Joung T. , Weaver Christopher M. , Martin Jennifer L. , Caskey Nicholas H. , O'Riley Alisa , Kramer Betty Josea 
Published: January 2012

AbstractOlder adults are among the highest at risk for completing suicide, and they are more likely to seek mental health services from providers outside of traditional mental health care, but providers across the spectrum of care have limited training in suicide risk assessment and management and particularly lack training in suicide prevention for older adults. An educational program was developed to increase awareness and improve suicide risk assessment and management training for a range of healthcare providers who may see older adults in their care settings. One hundred thirty‐two participants from two Veterans Affairs Medical Centers participated in a 6.5‐hour‐long workshop in the assessment and management of suicide risk in older adults. Participants were asked to complete pre‐ and postworkshop case notes and report on subjective changes in knowledge, attitudes, and confidence in assessment and managing suicide risk in older adults. Participants included social workers, nurses, physicians, psychologists, and occupational therapists from a variety of care settings, including outpatient and inpatient medical, outpatient and inpatient mental health, specialty clinics, home, and community. After the workshop, participants demonstrated improvement in the overall quality of case notes (P = .001), greater ability to recognize important conceptual suicide risk categories (P = .003), and reported heightened awareness of the importance of late‐life suicide. The results suggest that educational training may have beneficial effect on the ability of multidisciplinary care providers to identify and manage suicide risk in elderly adults.
Total Hip Replacement after Failed Femoral Head and Neck Excision in Two Dogs and Two Cats
Authors: Fitzpatrick Noel , Pratola Laura , Yeadon Russell , Nikolaou Christos , Hamilton Michael , Farrell Michael 
Published: January 2012

ObjectiveTo document outcome in 2 dogs and 2 cats after conversion of femoral head and neck excision (FHNE) to total hip replacement (THR).Study DesignCase series.AnimalsDogs (n = 2) and 2 cats.MethodsFor 1 dog and 2 cats, THR was performed using cemented acetabular and femoral components. Noncemented acetabular and cemented femoral components were used in 1 dog.ResultsAll animals presented with severe hip pain and chronic lameness after unsuccessful FHNE. Potential causes of suboptimal outcome after FHNE were incomplete resection of the femoral neck (n = 3) and fibrous adhesions involving the sciatic nerve (n = 2). Post‐FHNE remodeling of the proximal femur and acetabulum necessitated unconventional modifications of surgical technique. In all 4 cases, final clinical outcome and radiographic reassessment were satisfactory. Aseptic loosening of the acetabular bone‐cement interface necessitating surgical revision was the only complication noted in 1 cat.ConclusionsDespite severe preoperative pain and chronic functional impairment in all cases, conversion of FHNE to THR produced marked clinical improvement including return to unrestricted exercise within 12 weeks of surgery.
From Game Protection to Wildlife Management: Frame Shifts, Organizational Development, and Field Practices
Authors: Brulle Robert J. , Benford Robert D. 
Published: January 2012

AbstractOne enduring question in social movements research is the relationship between cultural representations and organizational structure. In this article, we examine the development of different discursive frames over time, and how such frame shifts affect movement structure and practices. This approach seeks to illuminate the dialectical interplay between the movement community's discursive frame and its practices, and thus expand our understanding of the process of social movement growth and change. Through a close qualitative and historical analysis of a discursive shift within the hunting community of the United States in the 1930s from a focus strictly on game protection to a more expanded discursive frame of wildlife management, we show how this cultural shift led to major changes in both the organizational structure and advocacy goals of this social movement. We conclude with a discussion of how this process can be further studied.
Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF‐1 in a rat model
Authors: Schuh Alexander , Kroh Andreas , Konschalla Simone , Liehn Elisa A. , Sobota Radoslav M. , Biessen Erik AL. , Bot Ilze , Sönmez Tolga Taha , Schober Andreas , Marx Nikolaus , Weber Christian , Sasse Alexander 
Published: January 2012

AbstractCell based therapy has been shown to attenuate myocardial dysfunction after myocardial infarction (MI) in different acute and chronic animal models. It has been further shown that stromal‐cell derived factor‐1α (SDF‐1α) facilitates proliferation and migration of endogenous progenitor cells into injured tissue. The aim of the present study was to investigate the role of exogenously applied and endogenously mobilized cells in a regenerative strategy for MI therapy. Lentivirally SDF‐1α‐infected endothelial progenitor cells (EPCs) were injected after 90 min. of ligation and reperfusion of the left anterior descending artery (LAD) intramyocardial and intracoronary using a new rodent catheter system. Eight weeks after transplantation, echocardiography and isolated heart studies revealed a significant improvement of LV function after intramyocardial application of lentiviral with SDF‐1 infected EPCs compared to medium control. Intracoronary application of cells did not lead to significant differences compared to medium injected control hearts. Histology showed a significantly elevated rate of apoptotic cells and augmented proliferation after transplantation of EPCs and EPCs + SDF‐1α in infarcted myocardium. In addition, a significant increased density of CD31+ vessel structures, a lower collagen content and higher numbers of inflammatory cells after transplantation of SDF‐1 transgenic cells were detectable. Intramyocardial application of lentiviral‐infected EPCs is associated with a significant improvement of myocardial function after infarction, in contrast to an intracoronary application. Histological results revealed a significant augmentation of neovascularization, lower collagen content, higher numbers of inflammatory cells and remarkable alterations of apoptotic/proliferative processes in infarcted areas after cell transplantation.
One‐year psychosocial functioning in patients in the early vs. late stage of bipolar disorder
Authors: Rosa A.R. , González‐Ortega I. , González‐Pinto A. , Echeburúa E. , Comes M. , Martínez‐Àran A. , Ugarte A. , Fernández M. , Vieta E. 
Published: January 2012

Rosa AR, González‐Ortega I, González‐Pinto A, Echeburúa E, Comes M, Martínez‐Àran A, Ugarte A, Fernández M, Vieta E. One‐year psychosocial functioning in patients in the early vs. late stage of bipolar disorder.Objective:  The aim of this 1‐year follow‐up study was to compare functional outcome as well as clinical differences between patients with first‐ and multiple‐episode bipolar disorder.Method:  Bipolar disorder patients with first (n = 60) and multiple episodes (n = 59) were recruited from two hospitals in Spain. The Functioning Assessment Short Test (FAST) was used to assess functioning. The Hamilton Depression Rating Scale (HAMD) and the Young Mania Rating Scale (YMRS) were administered to assess mood symptoms.Results:  As expected, patients with first episode experienced a greater functioning compared to patients with multiple episodes (11.26 ± 10.94 vs. 26.91 ± 13.96; t = 6.436, P < 0.001). There were significant demographic and clinical differences between both groups. Baseline depressive symptoms (F = 9.553, df = 4, 102; P < 0.001) and age (F = 14.145, df = 4, 103; P < 0.001) were significantly associated with poor functional recovery at 6‐month and 12‐month assessment, respectively, in a group of patients with multiple episodes.Conclusion:  Our data give support to the model of staging in bipolar disorder, showing that the enduring neurotoxicity of repeated episodes may contribute to sustained impairment in multiple areas of psychosocial functioning.
Autologous periodontal ligament cells in the treatment of class III furcation defects: a study in dogs
Authors: Suaid Fabricia Ferreira , Ribeiro Fernanda Vieira , Gomes Thaisângela Rodrigues Lopes E Silva , Silvério Karina Gonzales , Carvalho Marcelo Diniz , Nociti Francisco Humberto , Casati Marcio Zaffalon , Sallum Enilson Antônio 
Published: January 2012

AbstractAimThis study aimed to evaluate, histomorphometrically, the use of periodontal ligament cells (PDL cells) in the treatment of class III furcation defects.Material and MethodsPDL cells were obtained from the mandibular tooth extracted from each dog (7), cultured in vitro and phenotypically characterized. Bilateral class III furcation defects were created at mandibular 3rd and 4th premolars and were randomly assigned to: Control Group: coronally positioned flap, GTR Group: GTR, Sponge Group: carrier + GTR, Cell Group: carrier + PDL cells + GTR.ResultsAfter 3 months of healing, data analysis demonstrated that the Cell Group presented a superior length of new cementum (4.82 ± 0.61 mm; 3.66 ± 0.95 mm; 2.87 ± 0.74 mm and 1.70 ± 0.60 mm, p < 0.001), a greater extension of periodontal regeneration (3.43 ± 1.44 mm; 2.33 ± 0.95 mm; 1.52 ± 0.39 mm and 0.69 ± 0.59 mm, p = 0.001) and a larger area of new bone (5.45 ± 1.58 mm2; 3.94 ± 1.52 mm2; 2.91 ± 0.56 mm2 and 1.89 ± 0.95 mm2, p = 0.0012), when compared with Sponge, GTR and Control Group, respectively.ConclusionThe PDL cells in association with GTR may significantly promote periodontal regeneration in class III furcation defects surgically created in dogs.
Surgical and non‐surgical therapy with systemic antimicrobials for residual pockets in type 2 diabetics with chronic periodontitis: a pilot study
Authors: Mendonça Adriana Cutrim , Santos Vanessa Renata , Ribeiro Fernanda Vieira , Lima Jadson Almeida , Miranda Tamires Szeremeske , Feres Magda , Duarte Poliana Mendes 
Published: January 2012

AbstractAimThis study evaluated the effects of surgical (SD) and non‐surgical (NSD) debridements, associated with systemic antimicrobials, on clinical and immunological outcomes of residual pockets [RP; probing depth (PD) ≥5 mm with bleeding on probing] in type 2 diabetics.Material and MethodsA split‐mouth, randomized controlled trial was conducted in 21 subjects presenting at least two RP per contralateral quadrant. Subjects received metronidazole plus amoxicillin for 10 days and, contralateral quadrants were assigned to receive SD or NSD. Clinical parameters and local levels of interferon‐γ, interleukin (IL)‐17, IL‐23 and IL‐4 were assessed at baseline, 3 and 6 months post‐therapies.ResultsOverall, the mean number, PD and clinical attachment level (CAL) of RP improved significantly after therapies (p < 0.05), without differences between groups at any time‐point (p > 0.05). At quadrant level, only SD produced significant reductions in the mean CAL. Also, SD promoted higher reduction in PD from baseline to 6 months than NSD (p < 0.05). Levels of all cytokines were increased after SD compared with NSD (p < 0.05).ConclusionSD and NSD associated with systemic antimicrobials did not differ in terms of clinical benefits for RP in diabetics up to 6 months post‐therapies. RP treated by SD presented increased levels of cytokines.
Genotype and haplotype analysis of WNT genes in non‐syndromic cleft lip with or without cleft palate
Authors: Mostowska Adrianna , Hozyasz Kamil K. , Biedziak Barbara , Wojcicki Piotr , Lianeri Margarita , Jagodzinski Pawel P. 
Published: January 2012

Mostowska A, Hozyasz KK, Biedziak B, Wojcicka P, Lianeri M, Jagodzinski PP. Genotype and haplotype analysis of WNT genes in non‐syndromic cleft lip with or without cleft palate. Eur J Oral Sci 2012; 120: 1–8. © 2012 Eur J Oral SciThe wingless‐type MMTV integration site family (Wnt) signalling pathway plays a crucial role in craniofacial development. Recently, nucleotide variants in WNT genes have been shown to be associated with oral congenital anomalies, including facial clefts. Therefore, in the current study we decided to assay the association of nucleotide variants in selected WNT genes with the risk of non‐syndromic cleft lip with or without cleft palate (NCL/P) in the Polish population. Fourteen polymorphisms in WNT3, WNT3A, WNT5A, WNT8A, WNT9B, and WNT11 were tested in a group of 210 patients with NCL/P and in a properly matched control group. The most significant results were found for the WNT3 rs3809857 variant, which, under the assumption of a recessive model, was associated with a two‐fold decrease in the risk of NCL/P (ORTT vs. GT + GG = 0.492, 95% CI: 0.276–0.879, P = 0.015). Moreover, haplotype analysis revealed that WNT3 is significantly correlated with NCL/P. The global P‐values for haplotypes of rs12452064_rs7207916 and rs3809857_rs12452064_rs7207916 were 0.0034 and 0.0014, respectively, and these results were statistically significant, even after the permutation test correction. In conclusion, our study confirmed the involvement of polymorphisms in the WNT3 gene in NCL/P aetiology in the tested population.
The formation of immune complexes is involved in the acute phase of periodontal destruction in rats
Authors: Kuramoto A. , Yoshinaga Y. , Kaneko T. , Ukai T. , Shiraishi C. , Oshino K. , Ichimura I. , Hara Y. 
Published: January 2012

Kuramoto A, Yoshinaga Y, Kaneko T, Ukai T, Shiraishi C, Oshino K, Ichimura I, Hara Y. The formation of immune complexes is involved in the acute phase of periodontal destruction in rats. J Periodont Res 2012; 47: 455–462. © 2012 John Wiley & Sons A/SBackground and Objective: Loss of clinical attachment and alveolar bone destruction are major symptoms of periodontitis, caused by not only the destructive effect of periodontopathic bacteria but also the overactive response of the host immune system against periodontal pathogens. The details of the participation of the immune system in the onset and progression of periodontitis are unclear. In this study, we attempted to determine whether the host immune system, and in particular the formation of immune complexes, is involved in the periodontal destruction.Material and Methods: We applied ovalbumin or lipopolysaccharide (LPS) as antigens and their specific immunoglobulin G (IgG) antibodies purified from rat serum to rat gingival sulcus alternately. Loss of attachment, alveolar bone destruction and the numbers of inflammatory cells infiltrating the periodontal tissue and osteoclasts on the alveolar bone surface were investigated histometrically. The formation of immune complex was confirmed by immunohistological staining of complement C1qB.Results: Loss of attachment and the presence of C1qB were observed histopathologically in both experimental groups. The group that had been treated with LPS and anti‐LPS IgG showed greater loss of attachment. The number of inflammatory cells in the periodontal tissue was increased in both experimental groups, while osteoclasts at the alveolar bone crest were observed only in the group that had been treated with LPS and anti‐LPS IgG.Conclusion: In the present study, we showed that the formation of immune complex appears to be involved in the acute phase of periodontal destruction and that the biological activity of antigens is also important.
Maximal voluntary tongue pressure is decreased in Japanese frail elderly persons
Authors: Tsuga Kazuhiro , Yoshikawa Mineka , Oue Hiroshi , Okazaki Yohei , Tsuchioka Hirokazu , Maruyama Mariko , Yoshida Mitsuyoshi , Akagawa Yasumasa 
Published: January 2012

doi: 10.1111/j.1741‐2358.2011.00615.xMaximal voluntary tongue pressure is decreased in Japanese frail elderly personsBackground and objective:  To quantitatively estimate tongue function, we developed a handy device for intraoral pressure measurement. The objective of this study was to assess maximum voluntary tongue pressure (MVTP) in Japanese frail elderly persons receiving nursing care services.Materials and methods:  The study included 42 men and 87 women, aged 58–100 years. To record MVTP, the participants were asked to compress the balloon (diameter: 18 mm) of the disposable intraoral pressure probe onto their palates for 7 s using the maximum voluntary effort of the tongue. Pressures were recorded three times at 1 min intervals.Results:  Maximum voluntary tongue pressure was successfully measured in 111 persons. Mean (standard deviation) MVTP was 18 (12) kPa, with a range of 0–63 kPa. The remaining 18 persons could not accurately follow our instructions and MVTP could not be measured.Conclusion:  In comparison with the reported standard value using the same device, the frail elderly persons included in our study were found to exert less MVTP than healthy dentate individuals. These results suggest the need for proper quantitative evaluation of oral function, including tongue capacity, at nursing care facilities.
Ensuring a nurse practitioner workforce prepared to care for older adults: Findings from a national survey of adult and geriatric nurse practitioner programs
Authors: Auerhahn Carolyn , Mezey Mathy , Stanley Joan , Wilson Laurie Dodge 
Published: January 2012

Abstract  Purpose: To present the findings from a needs assessment of adult primary care (ANP), gerontological (GNP), and adult acute care (ACNP) nurse practitioner faculty regarding the transition to adult‐gerontology NP (A‐GNP) programs.Data sources: Data were obtained from two sources: (a) an online survey to identify the faculty's primary needs in order to facilitate success in this transition and (b) telephone focus groups to explore survey responses in greater depth.Conclusions: The survey and the focus group findings indicate that there is a strong need for (a) access to a set of nationally recognized competencies for A‐GNPs; (b) teaching/learning resources to support faculty in implementation of A‐GNP programs; and (c) formal faculty development opportunities to facilitate faculty efforts to engage in curricular redesign and innovations and assure that NP students acquire strong competence in gerontology content.Implications for practice: The transition to A‐GNP has implications not only for NP faculty but also for practicing NPs. Almost all NPs care for older adults in a variety of settings. However, most of these NPs are not specialists in geriatrics. This article provides a context for self‐assessment by these NPs of their own needs related to this transition.