bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Evaluation of Antiinflammatory, Antinociceptive, and Antiulcerogenic Activities of Novel Synthesized Thiazolyl and Pyrrolyl Steroids.
Authors: Mohareb Rafat M. , Elmegeed Gamal A. , Baiuomy Ayman R. , Eskander Emad F. , William Marian G. 
Published: December 2011

AbstractThis straightforward protocol provides access to modified steroids containing fused pyrrole or thiazole nuclei in addition to the pharmacophoric features of the steroid moiety.
ChemInform Abstract: Total Synthesis of (‐)‐Nakadomarin A.
Authors: Kyle Andrew F. , Jakubec Pavol , Cockfield Dane M. , Cleator Ed , Skidmore John , Dixon Darren J. 
Published: December 2011

AbstractThe marine alkaloid nakadomarin A (VII) is synthesized via a diastereoselective Michael addition reaction of ester (I) with nitro olefin (II) followed by a nitro‐Mannich/lactamization of ester (III) as key steps.
ChemInform Abstract: Quinolizidines Alkaloids: Petrosin and Xestospongins from the Sponge Oceanapia sp.
Authors: Singh Keisham Sarjit , Das Babulal , Naik Chandrakant G. 
Published: December 2011

AbstractThree new xestospongins (I) and (II) and six known alkaloids are isolated from title sponge.
ChemInform Abstract: Construction of Strong Alkaline Hydrothermal Environment for Synthesis of Copper Telluride Nanowires.
Authors: Wan Buyong , Hu Chenguo , Zhou Weijia , Liu Hong , Zhang Yan 
Published: December 2011

AbstractCu2‐xTe nanowires are hydrothermally synthesized from a 6 M KOH aqueous solution of CuCl2, Te powder, and hydrazine hydrate as reducing agent (autoclave, 200 °C, 24 h), followed by annealing at 250 °C for 4 h in N2.
ChemInform Abstract: SAR Analysis of Innovative Selective Small Molecule Antagonists of Sphingosine‐1‐phosphate 4 (S1P4) Receptor.
Authors: Urbano Mariangela , Guerrero Miguel , Zhao Jian , Velaparthi Subash , Schaeffer Marie‐Therese , Brown Steven , Rosen Hugh , Roberts Edward 
Published: December 2011

AbstractCYM 50333 (I) and CYM 50367 (II), novel selective S1P4 antagonists with activities in the nanomolar range, represent valuable small molecule tools to investigate the biological and pharmacological role of the target receptor in megakaryocyte differentiation and fundamental immune processes.
2‐Chlorotetrafluoroethanesulfinamide Induced Diastereoselective Three‐Component Aminoallylation of Aldehydes
Authors: Liu Lijuan , Liu Jintao 
Published: December 2011

AbstractThe diastereoselective three‐component reaction of aldehydes, allyl bromide, and (S)‐2‐chlorotetrafluoroethanesulfinamide was achieved in the presence of zinc powder and titanium(IV) isopropoxide. Compared to (S)‐tert‐butanesulfinamide, the reaction used zinc powder instead of indium and better results were obtained with aromatic aldehydes. Moreover, opposite stereoselectivity is observed.
Hydrogen Bonded Supramolecular Polymers in Both Apolar and Aqueous Media: Self‐Assembly and Reversible Conversion of Vesicles and Gels
Authors: Du Ping , Kong Jun , Wang Guitao , Zhao Xin , Li Guangyu , Jiang Xikui , Li Zhanting 
Published: December 2011

AbstractIn a preliminary letter (Tetrahedron Lett. 2010, 51, 188), we reported two new hydrazide‐based quadruple hydrogen‐bonding motifs, this is, two monopodal (1a and 1b) and five dipodal (2a, 2b and 3a–3c) aromatic hydrazide derivatives, and the formation of supramolecular polymers and vesicles from the dipodal motifs in hydrocarbons. In this paper, we present a full picture on the properties of these hydrogen‐bonding motifs with an emphasis on their self‐assembling behaviors in aqueous media. SEM, AFM, TEM and fluorescent micrographs indicate that all the dipodal compounds also form vesicles in polar methanol and water‐methanol (up to 50% of water) mixtures. Control experiments show that 1b does not form vesicles in same media. Addition of 1b to the solution of the dipodal compounds inhibits the latter's capacity of forming vesicles. At high concentrations, 3b and 3c also gelate discrete solvents, including hydrocarbons, esters, methanol, and methanol‐water mixture. Concentration‐dependent SEM investigations reveal that the vesicles of 3b and 3c fuse to form gels and the gel of 3c can de‐aggregate to form the vesicles reversibly.
Synthesis of Novel gem‐Difluoromethylene‐containing 1,2,3‐Triazoles via Click Reaction
Authors: Zhao Wenwen , Li Hui , Zhang Jian , Cao Song 
Published: December 2011

AbstractSeventeen novel gem‐difluoromethylene‐containing 1,2,3‐triazoles were synthesized by the click reaction of ethyl 2‐azido‐2,2‐difluoroacetate and terminal alkynes in the presence of 10 mol% CuI.
Difluoromethylation of O‐, S‐, N‐, C‐Nucleophiles Using Difluoromethyltri(n‐butyl)ammonium Chloride as a New Difluorocarbene Source
Authors: Wang Fei , Huang Weizhou , Hu Jinbo 
Published: December 2011

AbstractDifluoromethyltri(n‐butyl)ammonium chloride 1 was found to be an effective difluorocarbene reagent for O‐, S‐, N‐, C‐difluoromethylation under basic conditions. It is particularly remarkable that, when only 1.2 equivalent of reagent 1 was used, the difluoromethylated products were obtained in moderate to excellent yields.
Solvent‐ and Catalyst‐Free Direct Aldol Reactions
Authors: Wang Zongling , Zhang Chengpan , Zhang Chuntao , Zheng Yan‐Song , Xiao Jichang 
Published: December 2011

AbstractAldol reaction between simple benzaldehydes and ketones successfully happened in solvent‐ and catalyst‐free condition. The desired products were obtained in moderate yield at suitable temperature. Heat was assumed as the driving force for the reaction. This approach has obvious advantages to fully meet the requirement of the principles of green chemistry.
Au(I)‐Catalyzted Synthesis of 5‐Bromodifluoromethyl Pyrazoles from Fluorinated Alkynyl Ketones and Hydrazine
Authors: Li Shan , Li Zhengke , Peng Dongjie , Li Yajun , Zhu Jiangtao , Xie Haibo , Yuan Yafen , Chen Zixian , Wu Yongming 
Published: December 2011

AbstractFluorinated alkynyl ketones react with hydrazine to give fluorinated pyrazols in good to excellent yields with Au(I) as catalyst. All the reactions were carried out at room temperature with excellent regioselectivity.
An energy‐efficient localization algorithm for mobile vehicles in vehicle to vehicle network
Authors: Zhang Lingwen , Yang Gang 
Published: December 2011

SUMMARYTraditional vehicle localization is based on global positioning system. However, the global positioning system is limited in shadowed environments such as underground carports, tunnels, and urban zones. This paper describes a vehicle positioning solution in an urban environment with the aid of vehicle to vehicle (V2V) networking, which utilizes the existing roadside sensors of the V2V network. The designed localization scheme is based on angle of arrival measurements. Compared with beamforming, minimum variance distortionless response, and subspace‐based methods, an angle of arrival estimation method presented in this paper called sparsity angle sensing, based on a sparse representation of sensor measurements and compressive sensing theory, outperforms the other three methods in spatial resolution and robustness. Then the paper applies the novel angle of arrival estimation algorithm into an energy‐efficient localization scheme design in a V2V network. Compared with sensor‐based approaches, the proposed scheme relieves the requirements of sensor size and energy consumption, and reduces communication and computation overhead. Simulation results show the effectiveness of the proposed scheme in terms of reducing the positioning error. Copyright © 2011 John Wiley & Sons, Ltd.
Palliative care for extremely premature infants and their families
Authors: Boss Renee D. 
Published: December 2011

AbstractExtremely premature infants face multiple acute and chronic life‐threatening conditions. In addition, the treatments to ameliorate or cure these conditions often entail pain and discomfort. Integrating palliative care from the moment that extremely premature labor is diagnosed offers families and clinicians support through the process of defining goals of care and making decisions about life support. For both the extremely premature infant who dies soon after birth and the extremely premature infant who experiences multiple complications over weeks and months in the neonatal intensive care unit, palliative care can maintain a focus on infant comfort and family support. This article highlights the ways in which palliative care can be incorporated into intensive care for all critically ill infants. © 2011 Wiley Periodicals, Inc. Dev Disabil Res Rev 2010;16:296–301.
Preterm birth: An overview of risk factors and obstetrical management
Authors: Stewart Amanda , Graham Ernest 
Published: December 2011

AbstractPreterm birth is the leading cause of neonatal mortality and a major public health concern. Risk factors for preterm birth include a history of preterm birth, short cervix, infection, short interpregnancy interval, smoking, and African‐American race. The use of progesterone therapy to treat mothers at risk for preterm delivery is becoming more widespread. Tocolytics may not prevent preterm birth but have a role in prolonging pregnancy for administration of medications to benefit the preterm infant. These include antenatal steroids and, if indicated, magnesium sulfate for neuroprotection and intravenous antibiotics for Group B Streptococcus prophylaxis. © 2011 Wiley Periodicals, Inc. Dev Disabil Res Rev 2010;16:285–288.
Preterm birth: Transition to adulthood
Authors: Allen Marilee C. , Cristofalo Elizabeth , Kim Christina 
Published: December 2011

AbstractPreterm birth is associated with greater difficulty with transitions from childhood to adolescence to adulthood. Adolescents and young adults born preterm have higher rates of cerebral palsy, intellectual disability, cognitive impairment, learning disability, executive dysfunction, attention deficit disorder, and social‐emotional difficulties than their peers born fullterm. Compared to individuals born fullterm, more preterm survivors have major neurodevelopmental or psychiatric disability and need financial supports and societal resources. Neuroimaging studies of adolescents and adults born preterm report higher rates of brain injury, differences in regional brain structure, and different brain circuits than in those born fullterm. Making the transition to adulthood is more difficult for young adults who were born preterm than their peers born fullterm, in that fewer complete high school and higher education, find and keep meaningful employment, and live independently from their parents. As a group, they do not tend to be risk‐takers, and they have lower rates of alcohol abuse, use of illicit drugs, and criminal offenses than do their peers. Despite their many challenges, the majority of adults born preterm function well, form personal relationships, integrate well into their community, and are as satisfied with their quality of life as are their peers. Concerns regarding current preterm infants, with more extremely preterm survivors, overwhelming our medical, educational, and societal resources should serve as an impetus for research on prevention of preterm births and brain injury, as well as how to support and promote their ongoing neuromaturation and recovery from injury. © 2011 Wiley Periodicals, Inc. Dev Disabil Res Rev 2010;16:323–335.
Generation and control of electrolyte cathode atmospheric glow discharge using miniature gas flow
Authors: Shirai Naoki , Nakazawa Masato , Ibuka Shinji , Ishii Shozo 
Published: December 2011

AbstractStable electrolyte cathode atmospheric DC glow microdischarges were generated by using a miniature helium gas flow from a nozzle electrode in air. We developed two schemes to control the temporal evolution of the discharge and the interaction between the discharge column and the ambient air. The vaporization of electrolyte solutions takes place and affects the discharge characteristics. This takes time from the start of the discharge. Therefore, the discharge was controlled by applying pulse‐modulated DC voltages. If the voltage was dropped down to zero before the vaporization, the gas discharge developed without the ionization of the solution components. A helium gas discharge without air developed when the nozzle electrode was placed in a glass capillary. This was confirmed by examining the change in pH of the solution, which usually decreased owing to the generation of nitrogen oxides in the discharge in air. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 178(4): 8–15, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21222
Secure DV‐Hop localization scheme against wormhole attacks in wireless sensor networks
Authors: Labraoui Nabila , Gueroui Mourad , Aliouat Makhlouf 
Published: December 2011

ABSTRACTLocalization is an important topic in mobile wireless ad hoc and sensor networks, which has received considerable attention from the research community during the past few decades. In many sensor networks applications, location awareness is useful or even necessary. However, because of their key role in wireless sensor networks, localization systems can be the target of an attack that could compromise the entire functioning of a wireless sensor network. In this paper, we present a novel defense mechanism against wormhole attacks in DV‐Hop localization algorithm. The main idea of our approach is to plug in a proactive countermeasure to the basic DV‐Hop scheme called Infection prevention. We choose the wormhole attack as our defending target because it is a particularly challenging attack that can be successfully launched without compromising any nodes or having access to any cryptographic keys. Using analysis and simulation, we show that our solution is effective in detecting and defending against wormhole attacks with a high detection rate. Copyright © 2011 John Wiley & Sons, Ltd.
APPLICATION OF SOBEK HYDRAULIC SURFACE WATER MODELS IN THE NETHERLANDS HYDROLOGICAL MODELLING INSTRUMENT
Authors: Prinsen G. F. , Becker B. P. J. 
Published: December 2011

ABSTRACTThe Netherlands is a low‐lying country in the delta of the Rhine and Meuse rivers. Water management is a challenging task at times of high river discharges, but also during droughts, with salt intrusion being an important issue. When river discharges are low, several inlets in the western parts of the country cannot be used, because salinities exceed the standards. Climate change will increase the frequency of these problems. The Freshwater Policy study within the Dutch Delta Programme investigates how to deal with future freshwater supply and demand in the Netherlands.The Netherlands Hydrological modelling Instrument (NHI) has been developed in recent years by Deltares and Alterra in close cooperation with the Dutch Rijkswaterstaat‐Waterdienst, the Netherlands Environmental Assessment Agency, water boards and consultants. NHI is a set of integrated models for surface water, the unsaturated zone and groundwater. Surface water and salt balances are obtained using a 0‐dimensional water balance approach in combination with results of 1D‐hydrodynamic SOBEK flow models.NHI is the central model used in the Dutch Delta Programme's Freshwater Policy study. We will introduce the principles of NHI, the surface water components and their interaction, and discuss the first results of the study. Copyright © 2011 John Wiley & Sons, Ltd.
The heat shock protein 40 family of the malaria parasite Plasmodium falciparum
Authors: Rug Melanie , Maier Alexander G. 
Published: December 2011

AbstractFew diseases have had such a profound influence on human evolution and history as malaria. Despite intense efforts malaria infection continues to be a major killer. The causative agent of malaria, the unicellular eukaryote Plasmodium, displays a fascinating biology in which ubiquitous cellular concepts are modified to serve the particular needs of the malaria parasite. In this review, we explore how Plasmodium utilizes the heat shock protein 40 system, a chaperone system that ensures correct protein folding under normal and stress conditions. We highlight the peculiarities of the Plasmodium system and discuss whether any components of the system might be exploited for intervention strategies against this debilitating disease. © 2011 IUBMB
IUBMB Life, 63(12): 1081–1086, 2011.
Coping when pain is a potential threat: The efficacy of acceptance versus cognitive distraction
Authors: Jackson T. , Yang Z. , Li X. , Chen H. , Huang X. , Meng J. 
Published: December 2011

AbstractThis experiment investigated the impact of brief training in acceptance versus distraction‐based pain management on experimental pain tolerance in conditions of lower and higher potential threats. One hundred fifty‐one pain‐free Chinese adults (93 women, 58 men) randomly assigned to acceptance, distraction or pain education control conditions engaged in a cold pressor test (CPT) after reading validated orienting information designed to prime either the safety of the CPT (lower threat) or symptoms and damaging effects of exposure to extreme cold (higher threat). A 2 (threat level) × 3 (training strategy) analysis of covariance, controlling for pre‐intervention pain tolerance and education, indicated the acceptance group was more pain tolerant than other training groups. This main effect was qualified by an interaction with threat level: in the lower threat condition, acceptance group participants were more pain tolerant than peers in the distraction or pain education groups while no training group differences were found in the higher threat condition. Supplementary analyses identified catastrophizing as a partial mediator of training group differences in pain tolerance. In summary, findings suggested acceptance‐based coping is superior to distraction as a means of managing experimental pain, particularly when pain sensations are viewed as comparatively low in potential threat.
Pain in ambulatory HIV‐positive South Africans
Authors: Mphahlele N.R. , Mitchell D. , Kamerman P.R. 
Published: December 2011

AbstractWe investigated the prevalence and intensity of pain, factors associated with having pain, and analgesic medications employed in a population consisting predominantly of Black African and female human immunodeficiency virus (HIV)‐positive individuals attending outpatient clinics in a rural (n = 125; 79% female; 100% Black African) and a metropolitan (n = 396; 75% female; 94% Black African) area of South Africa. Pain intensity, interference and treatment were assessed using the Wisconsin Brief Pain Questionnaire. Seventy‐two percent of rural participants and 56% of metropolitan participants had pain at the time of the interview, and this pain was moderate to severe in intensity in 60% of rural participants and 59% of metropolitan participants. Forty‐six percent of rural participants and 61% of metropolitan participants had multiple pain sites. The most common pain sites in rural participants were the abdomen (30%), chest (26%), head (19%) and genitals (15%), while in the metropolitan cohort the head (39%), feet (33%), chest (30%) and abdomen (20%) were the most common sites. In the rural cohort, antiretroviral therapy was independently associated with reduced risk of pain, while in the metropolitan cohort increasing age was weakly, but independently associated with having pain. Pharmacological management of pain was poor, with 29% of rural participants and 55% of metropolitan participants with pain not receiving any treatment. Of those receiving treatment, no participants were receiving strong opioids, and only 3% of metropolitan participants were receiving a weak opioid. Thus, HIV‐related pain is common and is poorly treated in both the rural and metropolitan setting in South Africa.
Cognitive impairment in fibromyalgia syndrome: The impact of cardiovascular regulation, pain, emotional disorders and medication
Authors: Reyes del Paso G.A. , Pulgar Á. , Duschek S. , Garrido S. 
Published: December 2011

AbstractThis study investigated cognitive performance in fibromyalgia syndrome (FMS) and its association with cardiovascular and clinical parameters. Thirty‐five patients with FMS and 29 matched healthy controls completed a neuropsychological test measuring attention and arithmetic processing. As possible factors underlying the expected cognitive impairment, clinical pain intensity, co‐morbid depression and anxiety disorders, sleep complaints, medication use, as well as blood pressure parameters were investigated. The patients’ test performance was substantially reduced, particularly in terms of lower speed of cognitive processing and restricted improvement of performance in the course of the task. While the extent of depression, anxiety, fatigue and sleep complaints was unrelated to test performance, better performance was observed in patients showing lower pain ratings and those using opiate medication. The data corroborate the presence of substantial cognitive impairment in FMS. While the experience of chronic pain is crucial in mediating the deficits, co‐morbid depression, anxiety, fatigue and sleep complaints play only a subordinate role. In the control group, but not in the patients, blood pressure was inversely associated with mental performance. This finding is in line with the well known cognitive impairment in hypertension. The lack of this association in FMS confirms previous research showing aberrances in the interaction between blood pressure and central nervous function in the affected patients.
Experiential avoidance and anxiety sensitivity as dispositional variables and their relationship to the adjustment to chronic pain
Authors: Esteve R. , Ramírez‐Maestre C. , López‐Martínez A.E. 
Published: December 2011

AbstractAnxiety sensitivity has been included in the fear‐avoidance model as a vulnerability factor to explain individual differences in fear of pain. Several studies have suggested that the relationship between anxiety sensitivity and some psychopathological disorders is mediated by experiential avoidance, an affect‐related regulatory process that involves unwillingness to endure private experiences. The role of these constructs as vulnerability variables has not been investigated in chronic pain patients. The aim of this study was to investigate the role of anxiety sensitivity and experiential avoidance as dispositional variables in pain fear‐avoidance. Two alternative hypothetical models were tested: one in which anxiety sensitivity and experiential avoidance would be independently associated with pain fear‐avoidance; and second, one in which experiential avoidance would mediate the relationship between anxiety sensitivity and pain fear‐avoidance.The sample was composed of 299 patients with chronic back pain. The postulated relationships were tested using LISREL 8.20 software (Scientific Software International, Chicago, IL, USA) and the generally weighted least squares. The structural equation modelling analyses showed that experiential avoidance and anxiety sensitivity were independently associated with pain fear‐avoidance and that anxiety sensitivity had a stronger association with pain fear‐avoidance than experiential avoidance. The alternative model, in which experiential avoidance mediates the relationship between anxiety sensitivity and pain fear‐avoidance, gave a much worse fit.These results highlight the importance of both anxiety sensitivity and experiential avoidance as variables which could explain individual differences in pain fear‐avoidance. Thus, in terms of prevention, it should be a priority to identify patients with increased anxiety sensitivity and experiential avoidance during the first stages of the development of chronic pain conditions.