bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Utility of Prevena Negative Pressure Wound Therapy on Groin Incisions for Critical Limb-Threatening Ischemia
Authors: Yin Raymond , Gursky Alexis , Falade Israel , Knox Jacquelyn , Gomez-Sanchez Clara , Soroudi Daniel , Piper Merisa , Hoffman William , Hansen Scott L. 
Published: May 2024

Background
Incisional negative pressure wound therapy (iNPWT) is an adjunctive treatment that uses constant negative pressure suction to facilitate healing. The utility of this treatment modality on vascular operations for critical limb-threatening ischemia (CLTI) has yet to be elucidated. This study compares the incidence of postoperative wound complications between the Prevena Incision Management System, a type of iNPWT, and standard wound dressings for vascular patients who also underwent plastic surgery closure of groin incisions for CLTI.

Method
We performed a retrospective cohort study of 40 patients with CLTI who underwent 53 open vascular surgeries with subsequent sartorius muscle flap closure. Patient demographics, intraoperative details, and wound complications were measured from 2015 to 2018 at the University of California San Francisco. Two cohorts were generated based on the modality of postoperative wound management and compared on wound healing outcomes.

Results
Of the 53 groin incisions, 29 were managed with standard dressings, and 24 received iNPWT. Patient demographics, comorbidities, and operative characteristics were similar between the 2 groups. Patients who received iNPWT had a significantly lower rate of infection (8.33% vs 31.0%, P = 0.04) and dehiscence (0% vs 41.3%, P < 0.01). Furthermore, the iNPWT group had a significantly lower rate of reoperation (0% vs 17.2%, P = 0.03) for wound complications within 30 days compared with the control group and a moderately reduced rate of readmission (4.17% vs 20.7%, P = 0.08).

Conclusions
Rates of infection, reoperation, and dehiscence were significantly reduced in patients whose groin incisions were managed with iNPWT compared with standard wound care. Readmission rates were also decreased, but this difference was not statistically significant. Our results suggest that implementing iNPWT for the management of groin incisions, particularly in patients undergoing vascular operations for CLTI, may significantly improve clinical outcomes.
Soft Tissue Reconstruction After Sacral Neoplasm Resection
Authors: Falade Israel O. , Knox Jacquelyn A. , Piper Merisa L. , Hoffman William Y. , Hansen Scott L. 
Published: May 2024

Purpose
Resection of sacral neoplasms such as chordoma and chondrosarcoma with subsequent reconstruction of large soft tissue defects is a complex multidisciplinary process. Radiotherapy and prior abdominal surgery play a role in reconstructive planning; however, there is no consensus on how to maximize outcomes. In this study, we present our institution's experience with the reconstructive surgical management of this unique patient population.

Methods
We conducted a retrospective review of patients who underwent reconstruction after resection of primary or recurrent pelvic chordoma or chondrosarcoma between 2002 and 2019. Surgical details, hospital stay, and postoperative outcomes were assessed. Patients were divided into 3 groups for comparison based on reconstruction technique: gluteal-based flaps, vertical rectus abdominus myocutaneous (VRAM) flaps, and locoregional fasciocutaneous flaps.

Results
Twenty-eight patients (17 males, 11 females), with mean age of 62 years (range, 34–86 years), were reviewed. Twenty-two patients (78.6%) received gluteal-based flaps, 3 patients (10.7%) received VRAM flaps, and 3 patients (10.7%) were reconstructed with locoregional fasciocutaneous flaps. Patients in the VRAM group were significantly more likely to have undergone total sacrectomy (P < 0.01) in a 2-stage operation (P < 0.01) compared with patients in the other 2 groups. Patients in the VRAM group also had a significantly greater average number of reoperations (2 ± 3.5, P = 0.04) and length of stay (29.7 ± 20.4 days, P = 0.01) compared with the 2 other groups. The overall minor and major wound complication rates were 17.9% and 42.9%, respectively, with 17.9% of patients experiencing at least 1 infection or seroma. There was no association between prior abdominal surgery, surgical stages, or radiation therapy and an increased risk of wound complications.

Conclusions
Vertical rectus abdominus myocutaneous flaps are a more suitable option for patients with larger defects after total sacrectomy via 2-staged anteroposterior resections, whereas gluteal myocutaneous flaps are effective options for posterior-only resections. For patients with small- to moderate-sized defects, local fasciocutaneous flaps are a less invasive and effective option. Paraspinous flaps may be used in combination with other techniques to provide additional bulk and coverage for especially long postresection wounds. Furthermore, mesh is a useful adjunct for any reconstruction aimed at protecting against intra-abdominal complications.
Surgical Treatment of Breast Lymphedema: A Distinct Pathology With Unique Challenges
Authors: Szymanski Kathryn , Chun Fat Shelby , Brazio Philip S. 
Published: May 2024

Background
Supermicrosurgical advances such as lymphovenous bypass (LVB) have enabled effective physiologic treatment of lymphedema affecting the extremities. Reports of surgical treatment for breast lymphedema (BL) are sparse, consisting of case reports and almost exclusively LVB. We report our experience with BL, including a case of mastectomy and breast reconstruction with abdominal free flap and inguinal vascularized lymph node transfer (VLNT) for BL. We compare our series with the surgical literature to discern unique characteristics and treatment limitations inherent to this disease.

Methods
A database was prospectively maintained from September 2020 to May 2023 including all patients diagnosed with BL who were referred to our institution. Breast lymphedema was diagnosed using clinical criteria, and relevant patient data were recorded. Patients interested in surgical management underwent indocyanine green lymphography to determine candidacy for LVB or other interventions. All patients, including those surgically managed, were treated with complex decongestive therapy.

Results
Nine patients with BL were included. Eight had undergone breast-conserving therapy for breast cancer with whole breast irradiation. One patient was treated for Hodgkin lymphoma with axillary lymphadenectomy and axillary radiation. Indocyanine green lymphography was performed in 6 patients, of which 4 patients had diffuse dermal backflow. Two patients had lymphatic targets suitable for LVB, including the patient without breast irradiation. Three patients were managed surgically. One patient without bypass targets underwent breast reduction with partial symptomatic relief, later followed by a mastectomy with abdominal free flap reconstruction and VLNT. Two patients with suitable bypass targets underwent LVB, with resolution of breast swelling and subjective symptoms.

Conclusions
The diffuse lymphatic obliteration due to radiation field effect in BL results in a distinct pathophysiology compared with extremity lymphedema. Although published reports of surgical BL treatment almost exclusively describe LVB, other surgical options may be more frequently required. Ablative strategies such as mastectomy and regenerative techniques such as VLNT should be considered potential first-line treatment options for these patients.
An Analysis of the Characteristics and Trends in Practicing Plastic Surgeons in California
Authors: Aref Youssef , Engel Priya Vedula , Miao Xinfei , Givant Madeleine , Seify Hisham 
Published: May 2024

Background
Studies suggest an increasing trend of plastic surgeons choosing private practice after training, with up to 90% pursuing private practice without future fellowships.1 Previous data showed that 66.7% of graduates from plastic surgery residency programs chose to pursue private practice without future fellowship, while more recent studies estimate this statistic has risen close to 90%.1,2 The literature has yet to characterize the current plastic surgery workforce and changes in its composition over time. This study aims to analyze the characteristics and training of plastic surgeons in California through a comparative study with general surgeons.

Methods
Surgeon demographics were extracted from the Centers for Medicare and Medicaid Services open database. Urban/rural classification and academic affiliation were crosslinked from the Inpatient Prospective System database and sole proprietorship status was cross-linked from the NPI Registry. Summary statistics and logistic regressions with chi-squared analysis were analyzed using STATA/MP17.

Results
Our analysis consisted of 3871 plastic and general surgeons in California. Compared to general surgeons, plastic surgeons were less likely to be females (P < 0.000), and more likely to be sole proprietors (P < 0.000), and affiliated with a teaching hospital (P < 0.005). There was no statistically significant difference in the percentage of rural-practicing plastic and general surgeons (P = 0.590). More recent plastic surgery graduates were more likely to be affiliated with an academic hospital (P < 0.0000). The composition of females significantly increased from the older graduated cohort to the most recent one. There was no significant difference in sole proprietorship and rural practice status between the oldest and youngest graduating cohorts.

Conclusions
Although the California plastic surgery workforce is gaining female plastic surgeons and shifting to academic institutions, significant progress in serving rural communities is yet to be made. Our study suggests that there may be a shift in the trend of plastic surgeons opting for private practice, possibly driven by a desire for more stable positions in academia. Continued improvement in diversity and training of future plastic surgeons is needed to alleviate the rural care gap.
Assessment of Masseter Volume and Postoperative Stability After Orthognathic Surgery in Patients With Skeletal Class III Malocclusion With Facial Asymmetry
Authors: Zhao Qi , Chen Kai , Wang Xianzhu , Wu Guomin 
Published: May 2024

Objective:
This study aimed to evaluate the effect of orthognathic surgery on masseter volume in patients with skeletal Class III malocclusion with facial asymmetry and the effect of masseter volume on stability in orthognathic surgery.

Methods:
This research studied 16 patients with Class III malocclusion with facial asymmetry who received combined orthodontic-orthognathic treatment and underwent craniofacial computed tomography (CT) before (T0), 2 weeks after (T1), and 6 months after (T2) surgery. Three-dimensional (3D) CT images were retrospectively analyzed, using 3D volume reconstruction to obtain the masseter volume and examine the impact of the masseter volume on stability in orthognathic surgery.

Results:
A statistically significant difference (P < 0.05) in the volume of the masseter was found up to 6 months after orthognathic surgery compared with the preoperative period, and the reduction in the masticatory muscle volume on the lengthened side is greater than on the shortened side (P < 0.05). The volume of both masseters differed according to facial asymmetry, and the difference was significantly reduced after orthognathic surgery (P < 0.05). During the period time (T1–T2), cephalometric maxillary marker points were not significantly different (P > 0.05), and mandibular marker points were significantly anteriorly shifted (P < 0.05). There was an association between the masseter volume and anterior shift of point B (R > 0.5, P < 0.05), the upward and anterior shifts of the gonion point differed between the lengthened and shortened sides (P < 0.05).

Conclusion:
The size of the masseter becomes smaller 6 months after orthognathic surgery, and orthognathic surgery improves both bone and soft tissue symmetry. A larger sagittal relapse of mandibular setback occurred in patients with greater masseter volume. Considering these alterations may be helpful in planning orthognathic surgery.
H2O2mediated MAPK-mTOR crosstalk determines the XIAP and FLIP degradation pathways and development of resistance to Imatinib
Authors: Roy Rajdeep , Paul Tamalika , Sinha Samraj , Biswas Nabendu 
Published: May 2024

AbstractAbnormal or aggregated proteins degradation is very crucial to protect the cell against proteotoxic stress. Cellular proteins are usually degraded in a ubiquitin-dependent manner by proteasomes and macro-autophagy/autophagy. Both processes use ubiquitin, binding of which target them to proteasomes via ubiquitin-like domains or to phagophores (the precursors to autophagosomes) via Atg8/LC3 binding motifs. Since both pathways use ubiquitin, the question that arises is how degradative pathway choice is achieved. Here in this paper, we have shown that mTOR pathway acts as major player in deciding which degradation pathway to choose. Here, we used Imatinib resistant (K562R) and Imatinib-sensitive (K562S) K562 cell as our previous study showed that Ubiquitin-proteasome pathway is selected for degradation of two proteins XIAP and FLIP in Imatinib-resistant K562 cells. H2O2treatment in K562R cells degrades XIAP and FLIP via proteasomal pathway whereas H2O2degrades them via lysosomal pathway in K562S cells. We found H2O2mediated mTOR activation suppressed autophagy pathway in K562R cells and protein takes proteasomal degradation rout. However, proteins get degraded via autophagy when mTOR remains suppressed in K562S cells. We also found that H2O2-mediated activation of activation of ERK in turn activated mTOR in K562R cells because ROS inhibited ERK phosphorylation and thus mTOR remained inhibited in K562S cells. Moreover, we found that endogenous H2O2levels are way higher in K562R cells than in K562S cells. Finally, and most interestingly, our data clearly suggested that activation of mTOR is responsible for developing resistance to Imatinib in K562R cells. Thus, this paper delineates a very crucial role of H2O2and mTOR in both the selection of protein degradation pathway and development of drug resistant.
Bioinformatic evaluation of the potential oral-gut translocation of periodontal pathogens in patients with colorectal polyps
Authors: Takahashi Naoki , Yamaguchi Marin , Sato Keisuke , Tsuzuno Takahiro , Mineo Shuhei , Nakajima Nao , Takahashi Kazuya , Sato Hiroki , Miyazawa Haruna , Aoki-Nonaka Yukari , Ito Yutaro , Taniguchi Koji , Terai Shuji , Ito Kohei , Tabeta Koichi 
Published: May 2024

AbstractObjectiveThis study aimed to characterize the profiles of the oral and gut microbiota of patients with colorectal polyps using 16S rRNA gene sequencing and bioinformatic approaches.BackgroundPrevious studies have shown microbial translocation from the oral cavity to the gut, implying pathogenic impacts on gastroesophageal disease, including colorectal cancer (CRC). However, its details remain unclear.MethodsTwenty patients scheduled for endoscopic colorectal polypectomy were enrolled in this study. Oral samples (saliva and subgingival dental plaque) and intestinal samples (feces and swab of intestinal mucosa) were collected during preoperative and 6-month-postoperative reassessment periods. After sequencing the V3–V4 region of the bacterial 16S rRNA gene, several bioinformatic analyses (bacterial composition, diversity, core microbiome, and shared ASV) were performed on pre– and postoperative samples for each subject.ResultsThe bacterial composition was dominated byBacteroides,Streptococcus,Fusobacterium,Veillonella, andPrevotella_7in all four samples. Beta diversity analysis using weighted UniFrac distance distinctly segregated the samples between oral and intestinal environments in the principal coordinate analysis plot. Core microbiome analysis revealed thatStreptococcusandPorphyromonaswere dominantly shared in intra-oral environments. Additionally, alongsideStreptococcus, periodontitis-related bacteria, such asVeillonella,Fusobacterium,Porphyromonas,Prevotella_7,Haemophilus, andPrevotella, were identified as shared genera between oral and intestinal environments. Finally, shared ASV analysis demonstrated thatStreptococcuswas shared in the oral and intestinal environments of most patients, while periodontal pathogens were shared in some patients.ConclusionsThe core microbiome and shared ASV analyses revealed that several genes are shared between oral and intestinal environments in patients with colorectal polyps, indicating the oral–gut translocation of periodontitis-related bacteria. Further large-scale studies are needed to elucidate their involvement in CRC.
Stroboscopic time-of-flight neutron diffraction in long pulsed magnetic fields
Authors: Nakajima Taro , Watanabe Masao , Inamura Yasuhiro , Matsui Kazuki , Kanda Tomoki , Nomoto Tetsuya , Ohishi Kazuki , Kawamura Yukihiko , Saito Hiraku , Tamatsukuri Hiromu , Terada Noriki , Kohama Yoshimitsu 
Published: May 2024

We present proof-of-principle experiments of stroboscopic time-of-flight (TOF) neutron diffraction in long pulsed magnetic fields. By utilizing electric double-layer capacitors, we developed a long pulsed magnet for neutron diffraction measurements, which generates pulsed magnetic fields with the full widths at half maximum of >102 ms. The field variation is slow enough to be approximated as a steady field within the time scale of a polychromatic neutron pulse passing through a sample placed in a distance of the order of 101 m from the neutron source. This enables us to efficiently explore the reciprocal space using a wide range of neutron wavelength in high magnetic fields. We applied this technique to investigate field-induced magnetic phases in the triangular lattice antiferromagnets CuFe1−xGaxO2 (x=0,0.035).

Published by the American Physical Society
2024
Generation Z and Millennials’ food-sharing behaviour: a cross-generational analysis of motivations, satisfaction and behavioural intention
Authors: Poyoi Pimsuporn , Gassiot-Melian Ariadna , Coromina Lluís 
Published: May 2024

PurposePosting and sharing about food on social media has surged in popularity amongst younger generations such as Millennials and Generation Z. This study aims to analyse and compare food-tourism sharing behaviour on social media across generations. First, this study specifically investigates the factors influencing the intention to share food experiences on social media; second, it examines the impact of sharing intention on actual behaviour and loyalty; and third, it determines whether Millennials and Generation Z differ in these relationships.Design/methodology/approachA survey was carried out of Millennial and Generation Z travellers who shared food experiences on social media. Structural equation modelling (SEM) and multi-group analysis were performed to examine the cause-and-effect relationship in both generations.FindingsThe findings reveal differences in motivation, satisfaction, sharing intention, sharing behaviour and loyalty between generations (Millennials and Generation Z).Research limitations/implicationsThis study contributes to the literature on the antecedents of food-sharing behaviour in online communities by indicating factors that influence the sharing of culinary experiences and brand or destination loyalty across generations. Suggestions for future research include exploring online food-sharing behaviour through cross-cultural comparisons in various regions.Practical implicationsAs Millennials and Generation Z will expand their market share in the coming years, the findings of this study can help improve marketing strategies for culinary tourism and generate more intense food experiences for both generations.Originality/valueThe outcome of the research provides new insights to develop a conceptual model of food-sharing behaviour and tourism on social media by drawing comparisons across generations.
Uncovering the research tapestry: bibliometric insights into BIM and LCA – exploring trends, collaborations and future directions
Authors: Al Mahmud Jobaer , Arefin Shamsul , Ahmmed Md Imtiaz 
Published: May 2024

Purpose
This study aims to examine the historical development, present state and potential future directions of the integration between building information modeling (BIM) and life cycle assessment (LCA) in the field of construction. Additionally, this paper identifies current problems while offering insight into worldwide BIM research trends.

Design/methodology/approach
This study uses text mining on unstructured abstracts, a novel approach not previously documented in BIM research. By conducting a comprehensive systematic assessment of academic literature, this work uses advanced bibliometric approaches to examine the developmental trajectory of the integration of BIM and LCA. The research incorporates co-citation and keyword co-occurrence mapping, providing a complex visual depiction of the interconnectedness of information across different periods.

Findings
The results of this analysis reveal the historical development of the integration of BIM and LCA, including its roots and the initial research that established the foundation for further investigations. The aforementioned seminal works signify the inception of the discipline, serving as a source of inspiration for current scholarly investigations. Currently, there is a complex network of interdisciplinary cooperation that can be observed, combining knowledge and perspectives from the fields of design, engineering, construction and sustainability.

Originality/value
This research contributes novelty to the scholarly discourse by offering a holistic and up-to-date panorama of the dynamic BIM and LCA research landscape. It identifies emerging trends, influential contributors and uncharted territories, thus providing a foundation for scholars to contribute meaningfully to the advancement of knowledge in sustainable construction practices.