bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beclin1-induced Autophagy Abrogates Radioresistance of Lung Cancer Cells by Suppressing Osteopontin
Authors: Chang Seung-Hee , Minai-Tehrani Arash , Shin Ji-Young , Park Sungjin , Kim Ji-Eun , Yu Kyeong-Nam , Hong Seong-Ho , Hong Choong-Man , Lee Kee-Ho , R Beck George , Cho Myung-Haing 
Published: April 2012

Abstract
Osteopontin (OPN) serves as an indicator of resistance to radiotherapy. However, the role of OPN in the development of acquired radioresistance in human lung cancer cells has not yet been fully elucidated. Therefore, the potential importance of OPN as a marker of lung cancer with a potential significant role in the development of radioresistance against repeated radiotherapy has prompted us to define the pathways by which OPN regulates lung cancer cell growth. In addition, autophagy has been reported to play a key role in the radiosensitization of cancer cells. Here, we report that increased OPN expression through induction of nuclear p53 following irradiation was inhibited by exogenous beclin-1 (BECN1). Our results clearly show that BECN1 gene expression led to induction of autophagy and inhibition of cancer cell growth and angiogenesis. Our results suggest that the induction of autophagy abrogated the radioresistance of the cancer cells. Interestingly, we showed that knockdown of OPN by lentivirus-mediated shRNA induced the autophagy of human lung cancer cell. Taken together, these results suggest that OPN and BECN1 can be molecular targets for overcoming radioresistance by controlling autophagy.
Scientific Expertise and the Athlete Biological Passport: 3 Years of Experience
Authors: Olaf Schumacher Yorck , d′Onofrio Giuseppe 
Published: April 2012

Abstract
Expert evaluation of biological data is a key component of the Athlete Biological Passport approach in the fight against doping. The evaluation consists of a longitudinal assessment of biological variables to determine the probability of the data being physiological on the basis of the athlete's on own previous values (performed by an automated software system using a Bayesian model) and a subjective evaluation of the results in view of possible causes (performed by experts). The role of the expert is therefore a key component in the process. Experts should be qualified to evaluate the data regarding possible explanations related to the influence of doping products and methods, analytical issues, and the influence of exercise or pathological conditions. The evaluation provides a scientific basis for the decision taken by a disciplinary panel. This evaluation should therefore encompass and balance all possible causes for a given blood profile and provide a likelihood for potential scenarios (pathology, normal variation, doping) that might have caused the pattern. It should comply with the standards for the evaluation of scientific evidence in forensics.
On the basis of their evaluation of profiles, experts might provide assistance in planning appropriate target testing schemes.
The representation of illness manifestation during the first psychiatric interview with patients preliminary diagnosed with depressive illness
Authors: Ziółkowska Justyna 
Published: April 2012

The representation of illness manifestation during the first psychiatric interview with patients preliminary diagnosed with depressive illness
The aim of the study is the analysis of patients' and doctors' discursive representation of mental health problems during the first psychiatric interview. The data comes from 16 initial psychiatric interviews recorded by doctors in three psychiatric hospitals in Poland. Assuming the discursive character of representation the analysis of the data has shown that the representation of illness manifestations in doctors and patients narratives differs. The doctors constructed mental health problems mainly as static and timeless existence of medical symptoms and patients' traits. Conversely, the patients constructed illness manifestations in terms of action, as dynamic and contextualised processes. Interestingly, the patients deprived themselves of control over the acting illness manifestations. Doctors' static picture of illness manifestations eliminates the possibility of exploring the complicated relationship between patients and their problems. An examination of the way patients construct illness manifestations could be relevant diagnostic information.
Improving Mechanical Properties of Sintered Wolfram Based Alloy with Liquid Phase Trough Controlled Cooling Parameters
Authors: Muresan R. , Riti-Mihoc E. , Prica C. , Bodea M. 
Published: April 2012

Improving Mechanical Properties of Sintered Wolfram Based Alloy with Liquid Phase Trough Controlled Cooling ParametersHeavy alloys with 90 and 93 w/o W and a 7:3 Ni: Fe ratio are usually produced by the liquid phase sintering of W, Ni, and Fe powder mixtures. The result is a two-phase microstructure of spherical W solid solution grains embedded in a matrix of Ni rich solid solution. UTS, elongation, and microstructure strongly depend on the composition of the atmosphere during liquid phase sintering, on the cooling conditions and/or on the composition of the protective atmosphere during the heat treatment and its cooling conditions if treatment was applied after sintering. The sintering atmosphere is usually hydrogen. This can assure a proper densification but in the same time it can give rise to embitterment of W/matrix boundaries accompanied by a drastically decreasing ductility. In order to avoid this effect, heat treatments are applied in a neutral atmosphere (Ar, N2, Ar+N2, etc.) to completely or partially remove the hydrogen from the sintered material. This paper studies the effect of protective atmosphere and cooling conditions on the UTS, elongation and microstructure of the above-mentioned two heavy alloys.
Thermodynamics Analysis of Non-Metallic Inclusions Formation in the Liquid Steel Flow Through Continuous Casting Tundish
Authors: Jowsa J. , Cwudziński A. 
Published: April 2012

Thermodynamics Analysis of Non-Metallic Inclusions Formation in the Liquid Steel Flow Through Continuous Casting TundishExperiments were conducted at industrial plant to determine the free and total oxygen contents in molten steel in the tundish during continuous casting blooms of sizes 280×280 mm. On the basis of industrial experiment results a thermodynamic evaluation of non metallic inclusion formation in liquid steel was performed. Software FactSage® with thermodynamic base packages were tested and applied to calculate equilibrium formation of oxides and sulphides. The results showed the effect of oxygen contents and temperature on the formation inclusion in liquid steel. Calculation results was presented in the form of suitable characteristics which were illustrated graphically.
Numerical Analysis of Liquid Steel Flow Structure in the One Strand Slab Tundish with Subflux Turbulence Controller and Dam
Authors: Cwudziński A. , Jowsa J. 
Published: April 2012

Numerical Analysis of Liquid Steel Flow Structure in the One Strand Slab Tundish with Subflux Turbulence Controller and Dam
The paper present the results of computational calculation showing liquid steel flow in the tundish. The one-strand slab tundish is used to casting slabs. The internal work space of tundish was modified by two flow control devices (FCDs). The first device is subflux turbulence controller situated in the pouring tundish zone. The second FCD is a dam with two holes. The dam presently using in the industrial conditions was modified by changing a height. Adapted to internal work space new flow control devices were located in the tundish virtual model. Numerical model and computational grid of tundish was performed in the Gambit application. The visualization of interaction of flow control devices on hydrodynamic conditions was received from numerical simulation. As a results of the computations carried out, liquid steel flow fields, turbulence intensity maps, steel temperature maps and RTD curves (E and F) were obtained. On the distribution of RTD characteristics, percentage contributions of stagnant, plug, ideal mixing flow type, and transition grade zone were calculated.
Distributed mass-balance modelling on two neighbouring glaciers in Ortles-Cevedale, Italy, from 2004 to 2009
Authors: Carturan Luca , Cazorzi Federico , Dalla Fontana Giancarlo 
Published: April 2012

AbstractA 6 year application of an enhanced temperature-index mass-balance model to Careser and La Mare glaciers, Eastern Italian Alps, is presented. The two glaciers exhibit very different characteristics, and a comprehensive dataset of distributed mass-balance measurements was used to test the model performance. The model was run using meteorological data acquired outside the glaciers. The work was focused on two main aspects: (1) the development of a morphological redistribution procedure for snow, and (2) the comparison of three different melt algorithms proposed in the literature. The results show that the simple method proposed for snow redistribution can greatly improve simulation of winter balance, and further improvements would be achievable by collecting data on inaccessible and high-altitude areas. All three melt formulations displayed a good skill level and very similar results in modelling the mass-balance distribution over glacier areas, with slightly better results from a multiplicative algorithm in capturing the vertical balance gradient. The simulation errors are related to aspect and elevation, and tend to be spatially aggregated. Some assumptions concerning the spatial and temporal distribution of air temperature and incoming solar radiation, although reasonable and widely used in the literature, may be responsible for this aggregation. Hence, there is a need to further investigate the processes that regulate the distribution of melt energy, and that appear to control the current deglaciation phase in this area.
La politique des deux axes
Authors: Tiberj Vincent 
Published: April 2012

Résumé	Les variables lourdes pèseraient de moins en moins dans le vote. Pourtant, cette baisse n’est pas générale. Certaines logiques sociales du vote demeurent. Enfin, la cohorte de naissance ou le diplôme émergent dans les explications du vote en 2007. Il s’agit ici d’expliquer les permanences et les mutations des logiques sociales du vote lors des quatre dernières élections présidentielles. En discutant et prolongeant la théorie de la old et de la new politics , on montre que ces évolutions ne sont pas dues à un changement de système de valeurs, mais à la politisation par les grands partis français des valeurs culturelles. Cette « politique des deux axes » a plusieurs conséquences. De nouvelles logiques sociales du vote émergent ; certains groupes sociaux (les cadres, les ouvriers) sont travaillés par des conflits de valeurs, quand d’autres (les « sans religion », les indépendants) n’en sont pas affectés.
Use of ground‐penetrating radar to map subsurface features at the Lapa do Santo archaeological site (Brazil)
Authors: Luis Porsani Jorge , de Matos Jangelme Guilherme , Kipnis Renato 
Published: April 2012

ABSTRACTIn this article we present some results of ground‐penetrating radar (GPR) studies carried out at the Lapa do Santo archaeological site. This cave is within the Lagoa Santa karstic region, Minas Gerais State, Brazil. Results from 44 GPR profiles obtained with 400 MHz shielded antennas indicated anomalous hyperbolic reflections and areas with high sub‐horizontal reflection amplitude suggesting archaeological and geological potential targets, respectively. These results were encouraging and were used to guide excavations at this site. Excavation of test units (metre by metre) allowed identifying an anthropogenic feature, e.g., a fire hearth structure and natural features, such as a stalagmite and top of bedrock. Results also indicated the importance of the GPR survey as a tool for orienting archaeological researches, increasing the probability of finding archaeological interest targets in an excavation program in an area of environmental protection.
Delusional Parasitosis: A Rare Cause of Pruritus in Hemodialysis Patients
Authors: Trigka Konstantina , Dousdampanis Periklis , Fourtounas Costas 
Published: April 2012

Uremic pruritus is a common symptom in patients undergoing hemodialysis (HD) or peritoneal dialysis, but its exact pathogenesis remains rather unclear. However, severe or “intractable” pruritus may be the manifestation of another underlying disease or disorder other than uremia. Delusional parasitosis, or Ekbom syndrome, is a rare psychiatric disorder characterized by the false conviction of being infested with parasites, and it can be primary, or secondary to several medical and psychiatric disorders. We report 2 elderly HD patients who presented one after another, with delusional parasitosis. At some point in time, the delusional beliefs of the first patient were adopted by the second patient who was waiting to start his HD session on the same bed and HD machine, on a subsequent shift. They were both diagnosed with Ekbom syndrome and described as having monosymptomatic hypochondriac delusion. They were both prescribed antipsychotic medications. During follow-up they admitted feeling better than before; however, they remained concerned about the “insects/parasites.”
Morbilidad materna extrema aguda por preeclampsia severa
Authors: Editorial Comité , Hernández Carlos Mata , Aguilar Nolvia 
Published: April 2012

Palabras claves: preeclampsia severa; morbilidad materna extrema; complicaciones; prevenibilidadDOI: http://dx.doi.org/10.5377/rmpm.v13i3.625 Revista de los Postgrados de Medicina UNAH Vol. 13 N° 3 Agosto-Octubre 2010
Towards an Architectural History of Performance: Auxiliarity, Performance and Provision in Historical Persian Architectures
Authors: Hensel Michael , Hensel Defne Sunguroğlu , Gharleghi Mehran , Craig Salmaan 
Published: April 2012

AbstractDespite its extensive empire, Persia historically presented a challenging environment for the building of structures and infrastructure. The mountainous landscape of the Iranian plateaus has an arid or semi‐arid climate with distinct seasonal variations and temperatures that fluctuated throughout the day. Despite this, water management and soil‐fertilisation strategies and passive environmental modulation in architecture were all highly developed previous to the 19th century so as to be finely attuned to the local context, while also responding to the greater demands of a centralised empire. Here Michael Hensel, Defne Sunguroğlu Hensel, Mehran Gharleghi and Salmaan Craig discuss and illustrate their detailed findings of the performance of historic structures. These include qanats (water canals), water cisterns, ice houses and pigeon houses as well as the seminal Khaju Bridge in Isfahan and the Boroujerdi's House in Kashan.
Persian Gardens and Landscapes
Authors: Faghih Nasrine , Sadeghy Amin 
Published: April 2012

AbstractThe verdant gardens of ancient Persia are a testament to this highly developed culture's resourcefulness and ability to not only source and direct water and irrigate the land in a hostile environment, but then to transform it into a manmade paradise. Here, Nasrine Faghih and Amin Sadeghy provide a historic outline of Persian garden typologies and their evolution over time, providing a focus on the central kiosk within the enclosed garden, highlighting the synergy between climate, resources and place.
Practices @ Home: Assimilating the Past and the Present for a Visionary Architecture
Authors: Gharleghi Mehran 
Published: April 2012

AbstractGuest‐Editor Mehran Gharleghi describes the work of four Iranian practices ‐ Fluid Motion Architects (FMA), Pouya Khazaeli Parsa, Arsh Design Studio and Kourosh Rafiey/Asar Consultant Engineers' Co) ‐ that are worthy of international attention. Over the last decade, all have distinguished themselves by developing a body of work ‘that is not only globally informed but also conscious and proud of its local, regional and national identity’.
Iran in the Regional Context
Authors: Derakhshani Farrokh 
Published: April 2012

AbstractFor much of its history, Iran was part of an extensive empire with far‐reaching trade and cultural networks. The current political situation, however, has often led to a misplaced patriotism that has emphasised the heritage of the nation state over its connections across the region. Farrokh Derakhshani flags up the danger of appropriating a wider common heritage from a local rather than a global perspective, and looks at Iran in the wider context of its immediate neighbours.
ChemInform Abstract: Transition‐Metal‐Centered Nine‐Membered Boron Rings: M@B9 and M@B‐9 (M: Rh, Ir).
Authors: Li Wei‐Li , Romanescu Constantin , Galeev Timur R. , Piazza Zachary A. , Boldyrev Alexander I. , Wang Lai‐Sheng 
Published: April 2012

AbstractThe transition‐metal‐centered boron clusters M©B‐9 (M: Rh, Ir) are produced in a laser‐vaporization supersonic molecular beam and characterized by PES and quantum chemical ab initio calculations at different levels of theory.
ChemInform Abstract: Ternary Arsenides A2Zn2As3 (A: Sr, Eu) and Their Stuffed Derivatives A2Ag2ZnAs3.
Authors: Stoyko Stanislav S. , Khatun Mansura , Mar Arthur 
Published: April 2012

AbstractThe title compounds are prepared from stoichiometric mixtures of the elements (800 °C, 7 d) and characterized by single crystal XRD, electrical resistivity measurements, and TB‐LMTO‐ASA band structure calculations.
ChemInform Abstract: A Vacancy‐Disordered, Oxygen‐Deficient Perovskite with Long‐Range Magnetic Ordering: Local and Average Structures and Magnetic Properties of Sr2Fe1.5Cr0.5O5.
Authors: Ramezanipour Farshid , Greedan John E. , Siewenie Joan , Donaberger Ronald L. , Turner Stuart , Botton Gianluigi A. 
Published: April 2012

AbstractThe metastable oxygen‐deficient title compound is characterized by powder X‐ray and neutron diffraction and EELS.
ChemInform Abstract: Investigation on Pseudosymmetry, Twinning and Disorder in Crystal Structure Determinations: Ba(H2O)M2III [PO3(OH)]4 (M: Fe, V) as Examples.
Authors: Sun Wei , Huang Ya‐Xi , Pan Yuanming , Mi Jin‐Xiao 
Published: April 2012

AbstractSmall average standard uncertainty of bond distances as an extremely sensitive criterion for determination of space groups is used to determine the crystal structures of the title compounds by single crystal XRD from twinned crystals.
ChemInform Abstract: K0.25Mn2O4 Nanofiber Microclusters as High Power Cathode Materials for Rechargeable Lithium Batteries.
Authors: Zhang Chaofeng , Feng Chuanqi , Zhang Peng , Guo Zaiping , Chen Zhixin , Li Sean , Liu Huakum 
Published: April 2012

AbstractThe title microclusters are hydrothermally synthesized from an aqueous solution of Mn(OAc)2, KNO3, and 2KHSO5·KHSO4·K2SO4 (autoclave, 80—130 °C, 20 h).
ChemInform Abstract: A New Approach to the Preparation of Nitrogen‐Doped Titania Visible Light Photocatalyst.
Authors: Kachina Anna , Puzenat Eric , Ould‐Chikh Samy , Geantet Christophe , Delichere Pierre , Afanasiev Pavel 
Published: April 2012

AbstractHighly dispersed N‐doped TiO2 is prepared by treatment of TiO2 powders with NH3/CCl4 mixtures at 450—600 °C for 3 h.
ChemInform Abstract: Oxothiomolybdenum Derivatives of the Superlacunary Crown Heteropolyanion {P8W48}: Structure of [K4{Mo4O4S4 (H2O)3(OH)2}2(WO2) (P8W48O184)]30‐ and Studies in Solution.
Authors: Korenev Vladimir S. , Floquet Sebastien , Marrot Jerome , Haouas Mohamed , Mbomekalle Israel‐Martyr , Taulelle Francis , Sokolov Maxim N. , Fedin Vladimir P. , Cadot Emmanuel 
Published: April 2012

AbstractReactions of the cyclic lacunary [H7P8W48O184]33‐ anion with the [Mo2S2O2(H2O)6] 2+ oxothiocation in aqueous medium are investigated by 31P and 183W NMR, and UV/VIS spectroscopy.
ChemInform Abstract: New CeMgCo4 and Ce2MgCo9 Compounds: Hydrogenation Properties and Crystal Structure of Hydrides.
Authors: Denys R. V. , Riabov A. B. , Cerny R. , Koval'chuk I. V. , Zavaliy I. Yu. 
Published: April 2012

AbstractThe title compounds are prepared by mechanical alloying of Mg with stoichiometric amounts CeCo4 or Ce2Co9 (obtained by arc‐melting in Ar) followed by annealing at 800 °C for 7 h under 1 bar argon.
ChemInform Abstract: Gold‐Catalyzed Cycloisomerization of Functionalized 1,5‐Enynes — An Entry to Polycyclic Framework.
Authors: Pradal Alexandre , Chen Qian , Faudot dit Bel Pierre , Toullec Patrick Yves , Michelet Veronique 
Published: April 2012

AbstractThe methodology is extended to subtrates bearing an aromatic side chain.
ChemInform Abstract: Tandem Cycloaddition Reactions of Allenyl Diazo Compounds Forming Triquinanes via Trimethylenemethane Diyls.
Authors: Kang Taek , Kim Won‐Yeob , Yoon Yeokwon , Kim Byung Gyu , Lee Hee‐Yoon 
Published: April 2012

AbstractThe tether length is found to be important for successful synthesis of tricyclic compounds.
ChemInform Abstract: [3 + 2] Cycloaddition Reaction of Cyclopropyl Ketones with Alkynes Catalyzed by Nickel/Dimethylaluminum Chloride.
Authors: Tamaki Takashi , Ohashi Masato , Ogoshi Sensuke 
Published: April 2012

AbstractThe use of organoaluminum compounds in catalytic or stoichiometric amounts is crucial for the success.
ChemInform Abstract: Highly Effective Recyclable Palladium‐Catalyzed Ligand‐Free Heck Reactions under Aerobic Conditions.
Authors: Sun Peng , Qu Xiaoming , Li Tingyi , Zhu Yan , Yang Hailong , Xing Zeyong , Mao Jincheng 
Published: April 2012

AbstractThe reaction of aryl iodides with a variety of reactive olefins is successfully achieved in the presence of Bu4NF.
ChemInform Abstract: Synthesis of Functionalized 3,4‐Diarylbenzophenones and 2,4‐Diarylbenzophenones by Site‐Selective Suzuki and Sonogashira Cross‐Coupling Reactions of Bis(triflates) 3,4‐ and 2,4‐Dihydroxybenzophenone.
Authors: Khera Rasheed Ahmed , Nawaz Muhammad , Feist Holger , Villinger Alexander , Langer Peter 
Published: April 2012

AbstractThe reactivity of bis(triflates) (I) and (XIV) of dihydroxybenzophenones is investigated.
ChemInform Abstract: Pd‐Catalyzed Regioselective and Stereospecific Suzuki—Miyaura Coupling of Allylic Carbonates with Arylboronic Acids.
Authors: Li Chenguang , Xing Juxiang , Zhao Jingming , Huynh Patrick , Zhang Wanbin , Jiang Pingkai , Zhang Yong Jian 
Published: April 2012

AbstractThe reaction of the regioisomer (IV) of substrate (I) suggests that the reductive elimination takes place at the less hindered site of the allylpalladium intermediate.
ChemInform Abstract: ortho‐Lithium/Magnesium Carboxylate‐Driven Aromatic Nucleophilic Substitution Reactions on Unprotected Naphthoic Acids.
Authors: Aissaoui Regadia , Nourry Arnaud , Coquel Ariane , Dao Thi Thanh Ha , Derdour Aicha , Helesbeux Jean‐Jacques , Duval Olivier , Castanet Anne‐Sophie , Mortier Jacques 
Published: April 2012

AbstractIt allows a new and effective access to a number of 1‐substituted 2‐naphthoic acids and 2‐substituted 1‐naphthoic acids.
ChemInform Abstract: Decarboxylative Benzylation and Arylation of Nitriles.
Authors: Recio Antonio III , Heinzman Jeffrey D. , Tunge Jon A. 
Published: April 2012

AbstractDecarboxylative benzylation of nitriles (I) is achieved via coupling of metallated nitriles with Pd‐π‐benzyl complexes that are generated in situ from cyanoacetic benzyl esters.
ChemInform Abstract: Synergistic Palladium‐Catalyzed C(sp3)—H Activation/C(sp3)—O Bond Formation: A Direct, Step‐Economical Route to Benzolactones.
Authors: Novak Petr , Correa Arkaitz , Gallardo‐Donaire Joan , Martin Ruben 
Published: April 2012

AbstractOxidation of ortho‐methylsubstituted benzoic acids is best achieved under conditions A) in the presence of the N‐protected amino acid NPL and different solvents.
ChemInform Abstract: Chiral Primary Amine Catalyzed Enantioselective Protonation via an Enamine Intermediate.
Authors: Fu Niankai , Zhang Long , Li Jiuyuan , Luo Sanzhong , Cheng Jin‐Pei 
Published: April 2012

AbstractAsymmetric Friedel—Crafts reaction of α‐substituted acroleins with various indoles gives the desired products in high yields and enantioselectivities.