bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of consumer participation during the new product development process on consumer brand identification: A gaming industry study
Authors: Correia Ricardo Fontes , Jakutis Lauryas , Vilkaitis Karolis , Survilaitė Eimantė , Venciute Dominika , de Sousa João Paulo Pereira 
Published: June 2024

AbstractThis study examines the role of consumer participation in the new product development process within the gaming industry, focusing on its impact on Consumer Brand Identification (CBI), with brand attractiveness as a mediating factor. Using a between‐subjects experimental design, we tested three scenarios of consumer participation and analyzed the data with one‐way ANOVA and mediation analysis. The findings reveal that although consumer involvement enhances brand attractiveness, it does not significantly increase brand identification. This research provides new insights into the limited effects of consumer participation on deepening brand connections despite its positive influence on brand perception. This study is one of the first to empirically explore the varying impacts of consumer participation on CBI within the gaming sector, offering a nuanced understanding of its role in shaping brand perception. Practical implications suggest that while consumer involvement is beneficial for enhancing brand attractiveness, its effectiveness in fostering brand identification is limited, and marketers should temper expectations when employing this strategy.
Clinical characteristics and literature review of chronic active Epstein–Barr virus‐associated enteritis
Authors: Meng Yajie , Li Rendong , Ding JieWen , Xiang Bo , Wang Qin , Wang Min , Tang KeJiang 
Published: June 2024

Key Clinical MessageChronic active Epstein‐Barr virus (EBV) infection‐associated enteritis (CAEAE) in nonimmunodeficient individuals is rare. To report a case of CAEAE, relevant articles were searched through databases. The clinical manifestations, endoscopic findings, strategies of treatment, prognoses, and follow‐up results of CAEAE patients were analyzed. Including this report, seven citations in the literature provide descriptions of 27 cases of CAEAE. There were 21 males and six females, with a mean age of 40 years. The main clinical manifestations were fever (25/27), abdominal pain (14/27), diarrhea (16/27), hematochezia or bloody stools (13/27), and decreased hemoglobin and red blood cell counts in routine blood tests (14/27). Elevations in inflammatory markers, white blood cell (WBC) counts, and C‐reactive protein (CRP) were common. Coagulation was often abnormal. Histopathology confirmed EBV‐encoded small nuclear RNA (EBER) in the affected tissue via in situ hybridization. The average serum EBV DNA load was 6.3 × 10^5 copies/mL. All patients had varying degrees of intestinal ulcers endoscopically, and the ulcers and pathology were uncharacterized and misdiagnosed mostly as inflammatory bowel disease (IBD). The course of the disease was progressive and later complicated by intestinal bleeding, intestinal perforation, septic shock, and a high rate of emergency surgery. However, the conditions of the patients often did not improve after surgery, and some patients soon died due to reperforation or massive hematochezia. Hormone and antiviral treatment had no obvious effect. There was a significant difference in surgical and nonsurgical survival (p < 0.05). The proportion of patients who died within 6 months was as high as 63.6% (7/11). CAEAE belongs to a group of rare, difficult conditions, has an insidious clinical course, has a high case fatality rate, and may later develop into EBV‐positive lymphoproliferative disorder (EBV‐LPD), which in turn leads to carcinogenesis. Clinicians should raise awareness that in patients with multiple ulcers in the intestine of unknown etiology, attention should be paid to EBV serology, and histology to make the diagnosis as early as possible.
Metastasectomy for extracalvarial renal cell carcinoma
Authors: Abo Kasem Rahim , Joseph Karan , Shaik Adnan , Downes Angela , Janjua M. Burhan 
Published: June 2024

Key Clinical MessagePalliative surgical resection of extra‐calvarial metastatic lesions from renal cell tumors is crucial for controlling metastatic spread, improving quality of life, and preventing associated morbidity. Careful surgical planning, including selective preoperative embolization and controlled resection around critical structures such as the sagittal sinus, is essential for successful outcomes. Cranioplasty with Titanium mesh and bone cement post‐resection can provide symptomatic relief, better cosmesis, and overall improved quality of life.AbstractRenal cell carcinomas are aggressive tumors with distant systemic disease. The calvarium appears to be an unusual and rare site for distant metastasis. The treatment modalities are challenging and out of the normal realm for the management of these tumors. We report a case of a 63‐year‐old woman with a previous history of nephrectomy who presented with symptoms of severe headaches, and swelling of bi‐frontal and bi‐parietal scalp regions due to multifocal extracalvarial disease. Preoperative bilateral superficial temporal artery embolization was performed to control the intraoperative bleeding. Surgical technique has been described with the critical steps involved, and a literature review has been conducted. Palliative tumor resection surgery was performed to improve the patient's quality of life as well as to confirm the histopathological diagnosis. Gross total resection of the extracalvarial metastatic tumor was achieved. Biopsy confirmed renal cell tumor with the clear cell subtype. The patient recovered well from her surgery with slow healing of the scalp wound. At 6‐month follow‐up, no recurrence of the extracalvarial disease was observed on serial imaging. Extracalvarial metastasis is a rare presentation in renal cell carcinoma. Considering the inherent radioresistant nature of the tumor, palliative surgical resection can be offered to control the metastatic spread, relieve agonizing pain symptoms, and to improve the quality of life. Preoperative embolization helps to decrease intraoperative blood loss. Moreover, palliative surgical resection of extracalvarial diseases helps to treat the metastasis as well as avoiding the associated morbidity that may occur if left untreated.
Synthesis of Planar Chiral Ferrocenes by Catalytic Desymmetrization Reactions
Authors: Qi Hongbo , Hang Nan‐Nan , Ming Jialin 
Published: June 2024

AbstractSince its discovery in the early 1950s, the sandwich‐type structure of ferrocene has sparked significant research into its applications across various disciplines, including asymmetric synthesis, medicinal chemistry, and materials science. Planar chiral ferrocenes play a crucial role in asymmetric catalysis by serving as essential scaffolds for chiral ligands and catalysts. Classical methods for synthesizing planar chiral ferrocenes often encounter limitations such as low atom economy and lengthy synthesis steps. In contrast, catalytic desymmetrization synthesis strategies offer a promising alternative due to their ability to enhance step and atom efficiency. This review highlights recent advancements in this field, particularly focusing on transition‐metal‐catalyzed C−H functionalization and catalytic enantioselective desymmetrization reactions.
ADH‐Catalyzed Biooxidation of (Hetero)aromatic sec‐Alcohols to Ketones Employing Vinyl Acetate as Acetaldehyde Surrogate
Authors: Rudzka Aleksandra , Reiter Tamara , Kroutil Wolfgang , Borowiecki Paweł 
Published: June 2024

AbstractThe oxidation of sec‐alcohols is a common reaction in organic chemistry. We report a biocatalytic approach for oxidizing racemic (hetero)aromatic sec‐alcohols to the corresponding ketones. The reaction relies on employing freeze‐dried E. coli cells containing a recombinant variant of an alcohol dehydrogenase deduced from Lactobacillus kefir (E. coli/Lk‐ADH Prince) and vinyl acetate as an in situ acetaldehyde surrogate as oxidant. Biooxidations of a set of 20 racemic (hetero)aromatic alcohols were carried out in the presence of a catalytic amount of NADP+ cofactor, the biocatalyst, and vinyl acetate in an aqueous medium to generate the corresponding ketones with up to >99 % conv. Preparative scale (1.0 mmol; 100 mM in 10 mL) reactions led to obtaining ketones in the 56–83 % isolated yield range.
Regulating Adsorption Behavior of Reactants on NiO/CuO/Co3O4 Surface by Electronic Effect to Promote Electrosynthesis
Authors: Zhu Yumei , Wu Jia , Wei Jinlv , Chen Rong , Zhai Zhixiang , Yin Shibin 
Published: June 2024

AbstractDeveloping efficient electrooxidation 5‐hydroxymethylfurfural (HMF) catalysts with high selectivity and fast reaction kinetic is challenging. The HMF oxidation reaction (HMFOR) involves the adsorption of HMF and OH− on the catalyst, thus understanding the adsorption behavior between the catalyst surface and reactants is vital. In this work, by studying the relationship between HMFOR performance and the adsorption behavior of reactants on different transition metal oxides (TMOs), it is discovered that the catalytic performance of TMOs is related to the adsorption capacity of OH− and HMF simultaneously. Subsequently, TMOs with different HMF and OH− adsorption abilities are coupled to further optimize the catalytic performance of HMFOR. Experimental and theoretical calculation results indicate that the electronic interactions between different TMOs can regulate the substrate adsorption behavior and electron transfer ability of the catalysts, which is beneficial for HMFOR. Among them, due to the strong interaction between the three components optimizes the adsorption capacity for HMF and OH−, NiO/CuO/Co3O4 exhibits the best HMFOR performance with FDCA selectivity of 99.6 % and formation rate of 16.45 mmol gcat−1 h−1. This work provides a design principle for HMFOR catalysts by modulating the adsorption behavior of reaction molecules.
Determination of N‐centered stereochemistry in N22‐methylated chlorophyll‐a derivatives and their epimer‐dependent optical spectra
Authors: Ataka Riko , Taniguchi Tohru , Monde Kenji , Tamiaki Hitoshi 
Published: June 2024

AbstractAn N‐centered epimeric mixture of chlorophyll‐a derivatives methylated at the inner nitrogen atom was separated by reverse‐phase high‐performance liquid chromatography. Circular dichroism (CD) spectroscopic analyses of the epimerically pure N22‐methyl‐chlorins revealed that the minor first‐eluted and major second‐eluted stereoisomers were (22S)‐ and (22R)‐configurations, respectively. Their visible absorption and CD spectra in solution were dependent on the N22‐stereochemistry. The epimer‐dependent spectral changes were independent of the substituents at the peripheral 3‐position of the core chlorin chromophore.
Mixed convective viscous dissipative flow of Casson hybrid nanofluid with variable thermal conductivity at the stagnation zone of a rotating sphere
Authors: Singla Tanvi , Kumar Bhuvaneshvar , Sharma Sapna 
Published: June 2024

AbstractMixed convection flows across the revolving bodies have eminent applications in science and technology, such as fibre coating, polymer deposition, centrifugal blood pumps, rotatory machinery, and so forth. In the current work, magnetohydrodynamic (MHD) flow and heat transfer characteristics of Casson hybrid nanofluid (Ag/MgO as nanoparticles) over the rotating sphere at the stagnation zone are being studied. Moreover, an analysis of heat transmission is conducted by considering the influence of thermal radiation, temperature‐dependent thermal conductivity, magnetic field, and viscous dissipation. The relevant partial differential equations are reformed into ordinary differential equations by appropriate transformations, which are solved using the successive linearization method (SLM). The thermal field, velocity components in x and z directions, heat transfer rate, and skin friction coefficient are computed for various physical quantities like rotation parameter mixed convection parameter, radiation parameter, Eckert number, Casson parameter, magnetic parameter, variable thermal conductivity parameter, and so forth. The current findings align well with the literature in a limiting sense. Thermal enhancement in hybrid nanofluid is observed for the viscous dissipation parameter (Ec), thermal conductivity parameter (), and radiation parameter (Rd). The degree of heat transfer rises from 12.8% to 20% when the Casson parameter's value () increases. Also, a decrease of approximately 33% is depicted between the peak values of the velocity magnitude with an increase in rotation parameter.
What do cancer genetic providers want us to know about variant reclassification and recontact that we are not asking? A thematic analysis of open‐ended survey responses
Authors: Brown Kerri , Ponton Marisel , Davidson Elenita , Arun Banu , Volk Robert J. , Shete Sanjay , Peterson Susan K. , Makhnoon Sukh 
Published: June 2024

AbstractBackgroundAccurate variant classification and relaying reclassified results to patients is critical for hereditary cancer care delivery. Over a 5‐ to 10‐year period, 6%–15% of variants undergo reclassification. As the frequency of reclassifications increases, the issue of whether, how, when, and which providers should recontact patients becomes important but remains contentious.MethodsThe authors used inductive thematic analysis to analyze open‐ended comments offered by oncologists and genetic counselors (GCs) from a large national survey.ResultsOf the 634 oncologists and cancer GCs, 126 (20%) offered substantive free‐text comments. Four thematic areas emerged: 1) ambiguity over professional responsibility to recontact, 2) logistical challenges with recontact, 3) importance of inter‐institutional communication, and 4) suggested solutions. Some oncologists felt that laboratories, not them, are responsible for recontact; others believed that ordering providers/GCs were responsible; GCs readily acknowledged their own responsibility in recontact but added important caveats. Besides the lack of up‐to‐date patient contact information, providers raised unique challenges with recontact: financial instability of laboratories, lack of clinical resources, contacting family members, and accumulating burden of reclassifications. There were numerous calls for developing practice guidelines on prioritizing variants for recontact and discussion on whether duty for recontact may be fulfilled via unidirectional, low touch modalities. Potential solutions to recontact including national databases and patient facing databases were discussed.ConclusionsThe authors confirm previous themes of stakeholder opinions and add previously unreported contextual details to qualify those themes. Clarifying provider responsibilities through professional guidelines for reclassification and recontact addressing the subthemes identified here will better serve all constituencies.
Taming XeO3 with Aza‐Crowns: Computational Studies into σ‐Hole Mediated Host‐Guest Interactions
Authors: Dash Soumya Ranjan , Vanka Kumar 
Published: June 2024

AbstractVarious aza‐crowns with different sizes and substituents have been explored computationally as potential hosts for stabilizing the explosive guest xenon trioxide (XeO3) through σ‐hole‐mediated aerogen bonding interactions. Interestingly, aza‐crowns demonstrate superior binding towards XeO3 compared to their oxygen and thio counterparts. However, unlike the latter cases, where the binding was found to be increasingly favorable with the increase in the size of the crowns, aza‐crowns exhibit a variable size preference for XeO3, peaking with aza‐15‐crown‐5, and reducing thereafter with increase in crown size.
Effects of Clinical Mutations in the Second Coordination Sphere and Remote Regions on the Catalytic Mechanism of Non‐Heme Fe(II)/2‐Oxoglutarate‐Dependent Aspartyl Hydroxylase AspH
Authors: Krishnan Anandhu , Waheed Sodiq O. , Melayikandy Sreerag , LaRouche Ciara , Paik Meredith , Schofield Christopher J. , Karabencheva‐Christova Tatyana G. 
Published: June 2024

AbstractAspartyl/asparaginyl hydroxylase (AspH) catalyzes the post‐translational hydroxylations of vital human proteins, playing an essential role in maintaining their biological functions. Single‐point mutations in the Second Coordination Sphere (SCS) and long‐range (LR) residues of AspH have been linked to pathological conditions such as the ophthalmologic condition Traboulsi syndrome and chronic kidney disease (CKD). Although the clinical impacts of these mutations are established, there is a critical knowledge gap regarding their specific atomistic effects on the catalytic mechanism of AspH. In this study, we report integrated computational investigations on the potential mechanistic implications of four mutant forms of human AspH with clinical importance: R735W, R735Q, R688Q, and G434V. All the mutant forms exhibited altered binding interactions with the co‐substrate 2‐oxoglutarate (2OG) and the main substrate in the ferric‐superoxo and ferryl complexes, which are critical for catalysis, compared to the wild‐type (WT). Importantly, the mutations strongly influence the energetics of the frontier molecular orbitals (FMOs) and, thereby, the activation energies for the hydrogen atom transfer (HAT) step compared to the WT AspH. Insights from our study can contribute to enzyme engineering and the development of selective modulators for WT and mutants of AspH, ultimately aiding in treating cancers, Traboulsi syndrome and, CKD.
Dynamic Covalent Chemistry of Enamine‐Ones: Exploring Tunable Reactivity in Vitrimeric Polymers and Covalent Organic Frameworks
Authors: Jadhav Thaksen , Dhokale Bhausaheb , Saeed Zeinab M. , Hadjichristidis Nikos , Mohamed Sharmarke 
Published: June 2024

AbstractDynamic covalent chemistry (DCC) has revolutionized the field of polymer science by offering new opportunities for the synthesis, processability, and recyclability of polymers as well as in the development of new materials with interesting properties such as vitrimers and covalent organic frameworks (COFs). Many DCC linkages have been explored for this purpose, but recently, enamine‐ones have proven to be promising dynamic linkages because of their facile reversible transamination reactions under thermodynamic control. Their high stability, stimuli‐responsive properties, and tunable kinetics make them promising dynamic cross‐linkers in network polymers. Given the rapid developments in the field in recent years, this review provides a critical and up‐to‐date overview of recent developments in enamine‐one chemistry, including factors that control their dynamics. The focus of the review will be on the utility of enamine‐ones in designing a variety of processable and self‐healable polymers with important applications in vitrimers and recyclable closed‐loop polymers. The use of enamine‐one linkages in crystalline polymers, known as COFs and their applications are also summarized. Finally, we provide an outlook for future developments in this field.
Toward Sustainable Polymer Materials for Rechargeable Batteries: Utilizing Natural Feedstocks and Recycling/Upcycling of Polymer Waste
Authors: Jeong Daun , Kwon Da‐Sol , Won Gwangbin , Kim Seunghyeon , Bang Joona , Shim Jimin 
Published: June 2024

AbstractThe ever‐increasing demand for rechargeable battery systems in the era of electric vehicles has spurred extensive research into developing polymeric components for batteries, such as separators, polymer electrolytes, and binders. However, current battery systems rely on expensive and nonrenewable resources, which potentially have a negative environmental impact. Therefore, polymer materials derived from natural resources have gained significant attention, primarily due to their cost‐effective and environmentally sustainable features. Moreover, natural feedstocks often possess highly polar functional groups and high molecular weights, offering desirable electro‐chemo‐mechanical features when applied as battery materials. More recently, various recycling and upcycling strategies for polymeric battery components have also been proposed given the substantial waste generation from end‐of‐life batteries. Recycling polymeric materials includes an overall process of recovering the components from spent batteries followed by regeneration into new materials. Polymer upcycling into battery materials involves transforming daily‐used plastic waste into high‐value‐added battery components. This review aims to give a state‐of‐the‐art overview of contemporary methods to develop sustainable polymeric materials and recycling/upcycling strategies for various battery applications.
From sampling to cellblock: The fully automated journey of cytological specimens
Authors: Taffon Chiara , Naciu Anda Mihaela , Bonfiglio Rita , Palumbo Valeria , Maricchiolo Giulia , Morano Vittoria , Salducci Mauro , Stigliano Serena , Palermo Andrea , Di Matteo Francesco Maria , Crescenzi Anna 
Published: June 2024

AbstractIn recent years, technological innovation have emerged to standardize pathology laboratory processes and reduce the handling of diagnostic samples. Among them is an automatic tissue embedding system that eliminates the need for manual activity in tissue paraffin embedding, thereby improving sample preservation. Unfortunately, this system cannot be used for cytological specimens due to the lack of an effective holder to support the procedure steps. In this study, we evaluated the performance of a commercial polymer matrix to enable and standardize the automatic paraffin embedding of cytological material from different organs and sources. Cytological samples from 40 patients were collected on the matrices and submitted for fully automatic workflow preparation, from formalin fixation until paraffin block, using the Sakura embedding system. Our results demonstrated the feasibility of the automated procedure, from loading cytological sample onto the matrix to obtaining the paraffin cellblock, thereby avoiding manual manipulation of cellular material. All samples resulted adequately processed and paraffin‐embedded showing satisfactory tissue permeation by processing reagents, optimal preservation of cytoplasmic and nuclear details, and good quality of staining results on paraffin sections. Automated embedding of cytological samples eliminates the risk of lost specimens, reduces laboratory burden, standardizes procedures, increases diagnostic yield, and ultimately improves patients' management.
Preparation and Aldol Couplings of 3(2H)‐Furanones: Stereoselective Synthesis of the C8‐C22 Fragment of Tuscoron A
Authors: Bieber Michelle Fernandez , Gao Xin , Wagner Raphael , Holzapfel Björn , Tomczyk Pascal , Menche Dirk 
Published: June 2024

AbstractVarious strategies for synthesis and stereroselective aldol coupling of furan‐3(2H)‐ones were evaluated that eventually enabled a highly stereroselective synthesis of the C8‐C22 fragment of tuscoron A.
Another Defense of Abortion: What Transplant Ethics Tells Us about the Ethics of Abortion after Dobbs
Authors: Shapiro Devora , Pannekoek Jeffrey 
Published: June 2024

AbstractIn 1971, two years before Roe v. Wade affirmed federal protection for abortion, Judith Jarvis Thomson attempted to demonstrate the wrongs of forced gestation through analogy: you awake to find that the world's most esteemed violinist is wholly, physically dependent on you for life support. Here, the authors suggest that Thomson's intuition, that there is a relevant similarity between providing living kidney support and forced gestation, is realized in the contemporary practice of living organ donation. After detailing the robust analogy between living kidney donation and gestation, we turn to current ethical guidelines incorporated in the United Network for Organ Sharing's requirements for legally authorized organ donation and transplantation. We conclude that if, as we—and Thomson—suggest, organ donation and gestation are relevantly similar, then the ethical framework supporting donation may aid in articulating ethical grounds that will be compelling in informing the legal grounds for a defense of abortion.