bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Fund Performance by Compromise Programming with Linear‐Quadratic Composite Metric: An Actual Case on The CaixaBank in Spain
Authors: Bravo Mila , Ballestero Enrique , Pla‐Santamaria David 
Published: June 2012

ABSTRACTThis paper proposes an additive measure on the basis of compromise programming to evaluate fund performance from multiple criteria, of which the most usual are profitability and risk. This proposal is motivated by the fact that compromise programming is a sound decision support model to obtain scores of alternatives by minimizing weighted distances to an ideal point, the weights reflecting the investor's preferences for the criteria. To define the distance objective function, the linear‐quadratic composite metric is used, which combines advantages of linear and non‐linear objective functions. A critical advantage of compromise programming for fund performance evaluation is that the model can be extended to more than two financial criteria while other measures currently used (either ratio‐based or leverage‐based measures) only consider two criteria, say, profitability and risk. In the application, three investor's profiles are defined, which involve different weighting systems and lead to different fund rankings. These rankings are compared with domination relationships, the latter formulating if a fund is dominated or non‐dominated by convex combinations of other funds. Numerical tables are provided with data, computational process and results, which are analysed. Copyright © 2012 John Wiley & Sons, Ltd.
QSAR, QSPR and QSRR in Terms of 3‐D‐MoRSE Descriptors for In Silico Screening of Clofibric Acid Analogues
Authors: Di Tullio Maurizio , Maccallini Cristina , Ammazzalorso Alessandra , Giampietro Letizia , Amoroso Rosa , De Filippis Barbara , Fantacuzzi Marialuigia , Wiczling Paweł , Kaliszan Roman 
Published: June 2012

AbstractA series of 27 analogues of clofibric acid, mostly heteroarylalkanoic derivatives, have been analyzed by a novel high‐throughput reversed‐phase HPLC method employing combined gradient of eluent’s pH and organic modifier content. The such determined hydrophobicity (lipophilicity) parameters, log kw, and acidity constants, pKa, were subjected to multiple regression analysis to get a QSRR (Quantitative StructureRetention Relationships) and a QSPR (Quantitative Structure‐Property Relationships) equation, respectively, describing these pharmacokinetics‐determining physicochemical parameters in terms of the calculation chemistry derived structural descriptors. The previously determined in vitro log EC50 values – transactivation activity towards PPARα (human Peroxisome Proliferator‐Activated Receptor α) – have also been described in a QSAR (Quantitative StructureActivity Relationships) equation in terms of the 3‐D‐MoRSE descriptors (3D‐Molecule Representation of Structures based on Electron diffraction descriptors). The QSAR model derived can serve for an a priori prediction of bioactivity in vitro of any designed analogue, whereas the QSRR and the QSPR models can be used to evaluate lipophilicity and acidity, respectively, of the compounds, and hence to rational guide selection of structures of proper pharmacokinetics.
α‐Bis and α,ω‐tetrakis(4‐dimethylaminophenyl) functionalized polymers by atom transfer radical polymerization using 1,1‐bis[(4‐dimethylamino)phenyl]ethylene as tertiary diamine initiator precursor and functionalizing agent
Authors: Summers Gabriel J , Ndawuni M Patrick , Summers Carol A 
Published: June 2012

AbstractThe quantitative syntheses of α‐bis and α,ω‐tetrakis tertiary diamine functionalized polymers by atom transfer radical polymerization (ATRP) methods are described. A tertiary diamine functionalized 1,1‐diphenylethylene derivative, 1,1‐bis[(4‐dimethylamino)phenyl]ethylene (1), was evaluated as a unimolecular tertiary diamine functionalized initiator precursor as well as a functionalizing agent in ATRP reactions. The ATRP of styrene, initiated by a new tertiary diamine functionalized initiator adduct (2), affords the corresponding α‐bis(4‐dimethylaminophenyl) functionalized polystyrene (3). The tertiary diamine functionalized initiator adduct (2) was prepared in situ by the reaction of (1‐bromoethyl)benzene with 1,1‐bis[(4‐dimethylamino)phenyl]ethylene (1) in the presence of a copper (I) bromide/2,2′‐bipyridyl catalyst system. The ATRP of styrene proceeded via a controlled free radical polymerization process to afford quantitative yields of the corresponding α‐bis(4‐dimethylaminophenyl) functionalized polystyrene derivative (3) with predictable number‐average molecular weight (Mn) and narrow molecular weight distribution (Mw/Mn) in a high initiator efficiency reaction. The polymerization process was monitored by gas chromatography analysis. Quantitative yields of α,ω‐tetrakis(4‐dimethylaminophenyl) functionalized polystyrene (4) were obtained by a new post ATRP chain end modification reaction of α‐bis(4‐dimethylaminophenyl) functionalized polystyrene (3) with excess 1,1‐bis[(4‐dimethylamino)phenyl]ethylene (1). The tertiary diamine functionalized initiator precursor 1,1‐bis[(4‐dimethylamino)phenyl]ethylene (1) and the different tertiary amine functionalized polymers were characterized by chromatography, spectroscopy and non‐aqueous titration measurements. Copyright © 2012 Society of Chemical Industry
Preparation and characterization of porous scaffold composite films by blending chitosan and gelatin solutions for skin tissue engineering
Authors: Rahman Mohammed Mizanur , Pervez Shahed , Nesa Bodrun , Khan Mubarak A 
Published: June 2012

AbstractBiodegradable polymers have significant potential in biotechnology and bioengineering. However, for some applications, they are limited by their inferior mechanical properties and unsatisfactory compatibility with cells and tissues. In the present investigation blends of chitosan and gelatin with various compositions were produced as candidate materials for biomedical applications. Fourier transform infrared spectral analysis showed good compatibility between these two biodegradable polymers. The composite films showed improved tensile properties, highly porous structure, antimicrobial activities, low water dissolution, low water uptake and high buffer uptake compared to pure chitosan or gelatin films. These enhanced properties could be explained by the introduction of free OH, NH2 and NHOCOCH3 groups of the amorphous chitosan in the blends and a network structure through electrostatic interactions between the ammonium ions (NH3+) of the chitosan and the carboxylate ions (COO−) of the gelatin. Scanning electron microscopy images of the blend composite films showed homogeneous and smooth surfaces which indicate good miscibility between gelatin and chitosan. The leafy morphologies of the scaffolds indicate a large and homogeneous porous structure, which would cause increased ion diffusion into the gel that could lead to an increase in stability in aqueous solution, buffer and temperature compared to the gelatin/chitosan system. In vivo testing was done in a Wistar rat (Rattus norvegicus) model and the healing efficiencies of the scaffolds containing various compositions of chitosan were measured. The healing efficiencies in Wistar rat of composites with gelatin to chitosan ratios of 10:3 and 10:4 were compared with that of a commercially available scaffold (Eco‐plast). It was observed that, after 5 days of application, the scaffold with a gelatin to chitosan ratio of 10:3 showed 100% healing in the Wistar rat; however, the commercial Eco‐plast showed only a little above 40% healing of the dissected rat wound. Copyright © 2012 Society of Chemical Industry
Prevalence and predictors of risky and heavy alcohol consumption among adult siblings of childhood cancer survivors
Authors: Lown E. Anne , Mertens Ann C. , Korcha Rachael A. , Leisenring Wendy , Hudson Melissa M. , Greenfield Thomas K. , Robison Leslie L. , Zeltzer Lonnie K. 
Published: June 2012

AbstractObjectiveTo describe alcohol consumption patterns and risk factors for risky and heavy alcohol use among siblings of childhood cancer survivors compared with survivors and national controls.MethodsSecondary analysis of prospectively collected data from two national surveys was performed including a cohort of 3034 adult siblings of childhood cancer survivors (age 18–56 years) and 10,398 adult childhood cancer survivors, both from the Childhood Cancer Survivor Study, plus 5712 adult participants from the population‐based National Alcohol Survey. Cancer‐related experiences, self‐reported current health, and mental health were examined in relation to alcohol consumption patterns including heavy and risky drinking.ResultsAdult siblings of childhood cancer survivors were more likely to be heavy drinkers (ORadj = 1.3; 1.0–1.6) and risky drinkers (ORadj = 1.3; 1.1–1.6) compared with controls from a national sample. Siblings were also more likely to drink at these two levels compared with survivors. Factors associated with heavy drinking among siblings included being 18–21 years old (ORadj = 2.9; 2.0–4.4), male (ORadj = 2.3; 1.7–3.0), having a high school education or less (ORadj = 2.4; 1.7–3.5), and drinking initiation at a young age (ORadj = 5.1; 2.5–10.3). Symptoms of depression, (ORadj = 2.1; 1.3–3.2), anxiety (ORadj = 1.9; 1.1–3.3), and global psychiatric distress (ORadj = 2.5; 1.5–4.3) were significantly associated with heavy alcohol use.ConclusionsSiblings of children with cancer are more likely to be risky and heavy drinkers as adults compared with childhood cancer survivors or national controls. Early initiation of drinking and symptoms of psychological distress should be identified during early adolescence and effective sibling‐specific interventions should be developed and made available for siblings of children with cancer. Copyright © 2012 John Wiley & Sons, Ltd.
Gender differences in health‐related quality of life, physical function and psychological status among patients in the early phase following allogeneic haematopoietic stem cell transplantation
Authors: Morishita Shinichiro , Kaida Katsuji , Yamauchi Shinya , Wakasugi Tatsushi , Yoshihara Satoshi , Taniguchi Kyoko , Ishii Shinichi , Ikegame Kazuhiro , Kodama Norihiko , Ogawa Hiroyasu , Domen Kazuhisa 
Published: June 2012

AbstractObjectiveThe aim of this study was to examine gender differences in quality of life (QOL), physical function and psychological status before and in the early phase after allogeneic haematopoietic stem cell transplantation (allo‐HSCT).MethodsOne hundred patients (66 men, 34 women) who underwent allo‐HSCT between July 2007 and June 2011 at Hyogo College of Medicine Hospital were included in this study. Patients were evaluated for health‐related QOL using the Medical Outcome Study 36‐item Short Form Health Survey; exercise capacity was measured with the 6‐min walk test, hand grip strength and knee extensor strength. Fatigue and psychological status were measured by the Piper Fatigue Scale and Hospital Anxiety and Depression Scale, respectively.ResultsWomen had significantly lower scores for physical function and general health on health‐related QOL tests compared with men (p < 0.01). No difference between genders was found in decline of physical function. In women, exercise capacity was strongly associated with QOL (p < 0.01). In men, depression and anxiety were closely related to QOL (p < 0.01).ConclusionsGender‐appropriate rehabilitation in allo‐HSCT patients is important. Women may need more endurance exercises and training for activities of daily life. Men may need rehabilitation including a psychological approach. Copyright © 2012 John Wiley & Sons, Ltd.
Progress toward multi‐robot reconnaissance and the MAGIC 2010 competition
Authors: Olson Edwin , Strom Johannes , Morton Ryan , Richardson Andrew , Ranganathan Pradeep , Goeddel Robert , Bulic Mihai , Crossman Jacob , Marinier Bob 
Published: June 2012

AbstractTasks like search‐and‐rescue and urban reconnaissance benefit from large numbers of robots working together, but high levels of autonomy are needed to reduce operator requirements to practical levels. Reducing the reliance of such systems on human operators presents a number of technical challenges, including automatic task allocation, global state and map estimation, robot perception, path planning, communications, and human‐robot interfaces. This paper describes our 14‐robot team, which won the MAGIC 2010 competition. It was designed to perform urban reconnaissance missions. In the paper, we describe a variety of autonomous systems that require minimal human effort to control a large number of autonomously exploring robots. Maintaining a consistent global map, which is essential for autonomous planning and for giving humans situational awareness, required the development of fast loop‐closing, map optimization, and communications algorithms. Key to our approach was a decoupled centralized planning architecture that allowed individual robots to execute tasks myopically, but whose behavior was coordinated centrally. We will describe technical contributions throughout our system that played a significant role in its performance. We will also present results from our system both from the competition and from subsequent quantitative evaluations, pointing out areas in which the system performed well and where interesting research problems remain. © 2012 Wiley Periodicals, Inc.
The software value map — an exhaustive collection of value aspects for the development of software intensive products
Authors: Khurum Mahvish , Gorschek Tony , Wilson Magnus 
Published: June 2012

SUMMARYIn software intensive products such as cars or telecom systems, software has traditionally been associated with cost, and there has been no real perception of its value in relation to the entire product offering. However, because software is becoming a larger part of the main competitive advantage, driving innovation and product differentiation, hardware is becoming more standardized, thus the valuation of software is becoming critical. In existing literature, several value constructs and corresponding valuation/measurement solutions needed for making decisions about software product development are presented. However, the contributions are often isolated with respect to a certain perspective such as focusing on product's internal or external quality aspects only. Consequently, a complete view of value constructs relevant from different perspectives required for making decisions about software product development is missing. This paper presents a consolidated view of the software value concept utilizing the major perspectives and introduces a software value map. The created value map was evaluated through an industry case study through the development of impact evaluation patterns, which were subsequently used by professionals in industry, and experiences gathered. During industry evaluation, practitioners found substantial benefits of having a consolidated, vastly improved, and extended value aspect's view of software. Copyright © 2012 John Wiley & Sons, Ltd.
Concise Review: Human Pluripotent Stem Cells in the Treatment of Spinal Cord Injury
Authors: Lukovic Dunja , Moreno Manzano Victoria , Stojkovic Miodrag , Bhattacharya Shom Shanker , Erceg Slaven 
Published: June 2012

Abstract
Spinal cord injury (SCI) results in neural loss and consequently motor and sensory impairment below the injury. There are currently no effective therapies for the treatment of traumatic SCI in humans. Different kinds of cells including embryonic, fetal, and adult stem cells have been transplanted into animal models of SCI resulting in sensorimotor benefits. Transplantation of human embryonic stem cell (hESC)- or induced pluripotent stem cell (hiPSC)-derived neural cells is nowadays a promising therapy for SCI. This review updates the recent progress in preclinical studies and discusses the advantages and flaws of various neural cell types derived from hESCs and hiPSCs. Before introducing the stem cell replacement strategies in clinical practice, this complex field needs to advance significantly in understanding the lesion itself, the animal model adequacy, and improve cell replacement source. This knowledge will contribute to the successful translation from animals to humans and lead to established guidelines for rigorous safety screening in order to be implemented in clinical practice.
Perceptions of geoengineering: public attitudes, stakeholder perspectives, and the challenge of ‘upstream’ engagement
Authors: Corner Adam , Pidgeon Nick , Parkhill Karen 
Published: June 2012

AbstractGeoengineering—the deliberate large‐scale manipulation of the planetary environment to counteract anthropogenic climate change—is receiving an increasing amount of attention from academics, policy and civil society stakeholders, and members of the general public. This article reviews the available literature on perceptions of geoengineering, including public attitudes and stakeholder perspectives. We describe some of the challenges of engaging with these audiences at such an ‘upstream’ phase in the development of geoengineering technologies. We conclude with reflections on the importance of eliciting public and stakeholder views, despite the challenges associated with upstream engagement, and identify a number of key research priorities for those involved in upstream engagement on geoengineering. WIREs Clim Change 2012 doi: 10.1002/wcc.176This article is categorized under:

Perceptions, Behavior, and Communication of Climate Change > Perceptions of Climate Change
Cross‐layer scheduling for multi‐users in cognitive multi‐radio mesh networks
Authors: Kim Wooseong , Park Joon‐Sang 
Published: June 2012

ABSTRACTA wireless mesh network has been popularly researched as a wireless backbone for Internet access. However, the deployment of wireless mesh networks in unlicensed bands of urban areas is challenging because of interference from external users such as residential access points. We have proposed Urban‐X, which is a first attempt towards multi‐radio cognitive mesh networks in industrial, scientific, and medical bands. Urban‐X first controls network topology with a distributed channel assignment to avoid interference in large timescale. In such a topology, we develop a new link‐layer transmission‐scheduling algorithm together with source rate control as a small‐timescale approach, which exploits receiver diversity when receivers of multi‐flows can have different channel conditions because of varying interference. For this purpose, mesh nodes probe the channel condition of received mesh nodes using group Request to Send and group Clear to Send. In this study, we establish a mathematical Urban‐X model in a cross‐layer architecture, adopting a well‐known network utility maximization framework. We demonstrate the feasibility of our idea using a simulation on the model. Simulation results show improved network throughput from exploiting receiver diversity and distributed channel assignment under varying external user interference. Copyright © 2012 John Wiley & Sons, Ltd.
The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation
Authors: Cosgrove Michael S. , Ding Ye , Rennie William A. , Lane Michael J. , Hanes Steven D. 
Published: June 2012

AbstractBicoid‐interacting protein 3 (Bin3) is a conserved RNA methyltransferase found in eukaryotes ranging from fission yeast to humans. It was originally discovered as a Bicoid (Bcd)‐interacting protein in Drosophila, where it is required for anterior–posterior and dorso‐ventral axis determination in the early embryo. The mammalian ortholog of Bin3 (BCDIN3), also known as methyl phosphate capping enzyme (MePCE), plays a key role in repressing transcription. In transcription, MePCE binds the non‐coding 7SK RNA, which forms a scaffold for an RNA–protein complex that inhibits positive‐acting transcription elongation factor b, an RNA polymerase II elongation factor. MePCE uses S‐adenosyl methionine to transfer a methyl group onto the γ‐phosphate of the 5′ guanosine of 7SK RNA generating an unusual cap structure that protects 7SK RNA from degradation. Bin3/MePCE also has a role in translation regulation. Initial studies in Drosophila indicate that Bin3 targets 7SK RNA and stabilizes a distinct RNA–protein complex that assembles on the 3′‐untranslated region of caudal mRNAs to prevent translation initiation. Much remains to be learned about Bin3/MeCPE function, including how it recognizes 7SK RNA, what other RNA substrates it might target, and how widespread a role it plays in gene regulation and embryonic development. WIREs RNA 2012 doi: 10.1002/wrna.1123This article is categorized under:

RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Translation > Translation Regulation
RNA Processing > Capping and 5' End Modifications
RNA in Disease and Development > RNA in Development
Effect of Anesthetic Methods on Cerebral Oxygen Saturation in Elderly Surgical Patients: Prospective, Randomized, Observational Study
Authors: Lee Aerina , Kim Sung‐Hoon , Hong Jeong‐Yeon , Hwang Jai‐Hyun 
Published: June 2012

AbstractBackgroundIntraoperative cerebral oxygen desaturation was reported to be associated with postoperative cognitive dysfunction in elderly patients. The effect of the anesthesia method on regional cerebral oxygen saturation (rSO2) is still a question under debate. The purpose of this study was to compare the effects of three common anesthesia methods on intraoperative rSO2 changes in elderly patients.MethodsIn this prospective randomized clinical trial, 87 patients scheduled for elective transurethral prostatectomy were allocated to receive general inhalational anesthesia (GA group, n = 30), spinal anesthesia (SA group, n = 28), or spinal anesthesia plus sedation with midazolam (SA+S group, n = 29).ResultsThe numbers of patients showing a decrease in rSO2 below the baseline value were higher in the SA (92.9 %) and SA+S (100 %) groups than in the GA group (33.3 %). The number of patients with a ≥50 % decrease in rSO2 below baseline was greater in the SA+S (31.0 %) group than in the GA (0 %) or SA (3.6 %) group. During surgery, patients subjected to general anesthesia had higher rSO2 than those with spinal anesthesia. Blood pressures and heart rates were similar in three groups except 5 and 10 min after anesthesia. Intraoperative SpO2 was higher in the GA group than in the two spinal anesthesia groups.ConclusionsSpinal anesthesia is associated with more frequent cerebral desaturation than general anesthesia; and it was aggravated when combined with midazolam sedation. The cerebral effects of anesthesia should be considered when managing high‐risk elderly patients.