bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convection Parameterization, Tropical Pacific Double ITCZ, and Upper-Ocean Biases in the NCAR CCSM3. Part II: Coupled Feedback and the Role of Ocean Heat Transport
Authors: Zhang Guang J. , Song Xiaoliang 
Published: August 2009

Abstract
This study investigates the coupled atmosphere–ocean feedback and the role of ocean dynamic heat transport in the formation of double ITCZ over the tropical Pacific in the NCAR Community Climate System Model, version 3 (CCSM3) and its alleviation when a revised Zhang–McFarlane (ZM) convection scheme is used. A hierarchy of coupling strategy is employed for this purpose. A slab ocean model is coupled with the atmospheric component of the Community Atmosphere Model, version 3 (CAM3) to investigate the local feedback between the atmosphere and the ocean. It is shown that the net surface energy flux differences in the southern ITCZ region between the revised and original ZM scheme seen in the stand-alone CAM3 simulations can cool the SST by up to 1.5°C. However, the simulated SST distribution is very sensitive to the prescribed ocean heat transport required in the slab ocean model. To understand the role of ocean heat transport, the fully coupled CCSM3 model is used. The analysis of CCSM3 simulations shows that the altered ocean dynamic heat transport when the revised ZM scheme is used is largely responsible for the reduction of SST bias in the southern ITCZ region, although surface energy flux also helps to cool the SST in the first few months of the year in seasonal variation.
The results, together with those from Part I, suggest that the unrealistic simulation of convection over the southern ITCZ region in the standard CCSM3 leads to the double-ITCZ bias through complex coupled interactions between atmospheric convection, surface winds, latent heat flux, cloud radiative forcing, SST, and upper-ocean circulations. The mitigation of the double-ITCZ bias using the revised ZM scheme is achieved by altering this chain of interactions.
Modeling Landfast Sea Ice by Adding Tensile Strength
Authors: König Beatty Christof , Holland David M. 
Published: August 2009

Abstract
Landfast ice is sea ice that forms and remains fixed along a coast, where it is either attached to the shore or held between shoals or grounded icebergs. The current generation of sea ice models is not capable of reproducing certain aspects of landfast ice behavior, for example the persistence of landfast sea ice under the effect of offshore winds. The authors develop a landfast sea ice model by adding tensile strength to the viscous–plastic as well as two versions of the elastic–viscous–plastic sea ice rheologies. One-dimensional implementations of these rheologies are used to explore the ability of coastal sea ice to resist offshore winds over extended times. While all modified rheologies are capable of maintaining landfast ice–like structures in the model, only the viscous–plastic rheology fulfills theoretical expectations. The elastic–viscous–plastic rheologies show initial elastic waves that weaken the ice and thus reduce its capacity of maintaining landfast ice. Further, special care has to be taken when implementing the most commonly used version of the elastic–viscous–plastic rheology because the standard set of parameters is not adequate for landfast sea ice modeling.
Defining the relationship between Plasmodium falciparum parasite rate and clinical disease: statistical models for disease burden estimation
Authors: Patil Anand P , Okiro Emelda A , Gething Peter W , Guerra Carlos A , Sharma Surya K , Snow Robert W , Hay Simon I 
Published: August 2009

AbstractBackgroundClinical malaria has proven an elusive burden to enumerate. Many cases go undetected by routine disease recording systems. Epidemiologists have, therefore, frequently defaulted to actively measuring malaria in population cohorts through time. Measuring the clinical incidence of malaria longitudinally is labour-intensive and impossible to undertake universally. There is a need, therefore, to define a relationship between clinical incidence and the easier and more commonly measured index of infection prevalence: the "parasite rate". This relationship can help provide an informed basis to define malaria burdens in areas where health statistics are inadequate.MethodsFormal literature searches were conducted forPlasmodium falciparummalaria incidence surveys undertaken prospectively through active case detection at least every 14 days. The data were abstracted, standardized and geo-referenced. Incidence surveys were time-space matched with modelled estimates of infection prevalence derived from a larger database of parasite prevalence surveys and modelling procedures developed for a global malaria endemicity map. Several potential relationships between clinical incidence and infection prevalence were then specified in a non-parametric Gaussian process model with minimal, biologically informed, prior constraints. Bayesian inference was then used to choose between the candidate models.ResultsThe suggested relationships with credible intervals are shown for the Africa and a combined America and Central and South East Asia regions. In both regions clinical incidence increased slowly and smoothly as a function of infection prevalence. In Africa, when infection prevalence exceeded 40%, clinical incidence reached a plateau of 500 cases per thousand of the populationper annum. In the combined America and Central and South East Asia regions, this plateau was reached at 250 cases per thousand of the populationper annum. A temporal volatility model was also incorporated to facilitate a closer description of the variance in the observed data.ConclusionIt was possible to model a relationship between clinical incidence andP. falciparuminfection prevalence but the best-fit models were very noisy reflecting the large variance within the observed opportunistic data sample. This continuous quantification allows for estimates of the clinical burden ofP. falciparumof known confidence from wherever an estimate ofP. falciparumprevalence is available.
Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: Involvement of integrin beta3 and focal adhesion kinase
Authors: Park Dong Wook , Choi Kyung-Chul , MacCalman Colin D , Leung Peter CK 
Published: August 2009

Abstract
Endometrial carcinoma is the most common neoplasm of the female genital tract, accounting for nearly one half of all gynecologic cancers in the Western world. Although intensive research on pathological phenomena of endometrial cancer is currently going on, but exact cause and biological aspects of this disease are not well described yet. In addition to well-documented roles of gonadotropin-releasing hormone (GnRH) in hypopituitary ovarian (HPO) axis, the agonistic or antagonistic analogs (or both) of GnRH have been shown to inhibit the proliferation of a variety of human gynecologic cancers. Thus, in the present study, we further examined the possibility that GnRH induces integrin beta3 and activation of focal adhesion kinase (FAK) through mitogen-activated protein kinases (MAPKs), ERK1/2 and p38, to inhibit the growth of HEC1A endometrial cancer cell line. As a result, both GnRH-I and GnRH-II resulted in a significant increase in integrin beta3 expression and evoked the activation of FAK in a time-dependent manner in these cells. In addition, these analogs induced an activation of ERK1/2 and p38 MAPK in a time-dependent manner as downstream pathways of FAK. It appears that GnRH-II has much greater effect on the activation of FAK, ERK1/2 and p38 compared to GnRH-I in these cells. Further, we demonstrated that the growth inhibition of HEC1A cells by GnRH-I or GnRH-II is involved in the activation of integrin-FAK and ERK1/2 and p38 MAPK pathways. Taken together, these results suggest that GnRH may be involved in the inhibition of endometrial cancer cell growth via activation of integrin beta3 and FAK as a direct effect. This knowledge could contribute to a better understanding of the mechanisms implicated in the therapeutic action of GnRH and its biomedical application for the treatment against endometrial cancer.
Twelve years of clinical practice guideline development, dissemination and evaluation in Canada (1994 to 2005)
Authors: Kryworuchko Jennifer , Stacey Dawn , Bai Nan , Graham Ian D 
Published: August 2009

Abstract

Background
Despite the growing availability of clinical practice guidelines since the early 1990's, little is known about how guideline development and dissemination may have changed over time in Canada. This study compares Canadian guideline development, dissemination, and evaluation in two six year periods from 1994–1999 and 2000–2005.

Methods
Survey of guideline developers who submitted their clinical practice guidelines to the Canadian Medical Association Infobase (a Canadian guideline repository) between 1994 and 2005. Survey items included information about the developers, aspects of guideline development, and dissemination and evaluation activities.

Results
Surveys were sent to the developers of 2341 guidelines in the CMA Infobase over the 12 year period, 1664 surveys were returned (response rate 71%). Of these, 730 unique guidelines were released from 1994–1999, and 630 were released from 2000–2005. Compared to the earlier period, more recent guidelines were being produced in English only. There has been little change in the type of organizations developing guidelines with most developed by provincial and national organizations. In the recent period, developers were more likely to report using computerized search strategies (94% versus 88%), publishing the search strategy (42% versus 34%), reaching consensus using open discussion (95% versus 78%), and evaluating effectiveness of the dissemination strategies (12% versus 6%) and the impact of the CPGs on health outcomes (24% versus 5%). Recent guidelines were less likely to be based on literature reviews (94% versus 99.6%) and were disseminated using fewer strategies (mean 4.78 versus 4.12).

Conclusion
Given that guideline development processes have improved in some areas over the past 12 years yet not in others, ongoing monitoring of guideline quality is required. Guidelines produced more recently in Canada are less likely to be based on a review of the evidence and only about half discuss levels of evidence underlying recommendations. Guideline dissemination and implementation activities have actually decreased. Unfortunately, the potential positive impact on patient health outcomes will not be realized until the recommendations are adopted and acted upon.
A review of COFRADIC techniques targeting protein N-terminal acetylation
Authors: Van Damme Petra , Van Damme Jozef , Demol Hans , Staes An , Vandekerckhove Joël , Gevaert Kris 
Published: August 2009

Abstract
Acetylation of nascent protein Nα-termini is a common modification among archae and eukaryotes and can influence the structure and function of target proteins. This modification has been studied on an individual protein or (synthetic) peptide level or on a proteome scale using two-dimensional polyacrylamide gel electrophoresis. We recently developed mass spectrometry driven proteome analytical approaches specifically targeting the amino (N) terminus of proteins based on the concept of diagonal reverse-phase chromatography. We here review how this so-called combined fractional diagonal chromatography (COFRADIC) technique can be used in combination with differential mass-tagging strategies as to both qualitatively and quantitatively assess protein Nα-acetylation in whole proteomes.
Evaluation of Compliance with a Paper-based, Multiplication-factor, Intravenous Insulin Protocol
Authors: Cyrus Rachel M , Szumita Paul M , Greenwood Bonnie C , Pendergrass Merri L 
Published: August 2009

Background: Hyperglycemia is common in critically ill patients and is an independent risk factor for in-hospital morbidity and mortality. Objective: To assess compliance with a paper-based, multiplication-factor, intravenous insulin protocol. Methods: A retrospective chart review was conducted in a 720-bed urban, academic medical center in Boston, Massachusetts. During a 1-month period, compliance with and the consequent safety and efficacy of the Brigham and Women's Hospital paper-based, multiplication-factor, intravenous insulin protocol was evaluated. Results: The primary endpoint of protocol compliance, defined as correct adjustment to insulin infusion rate and correct timing of bedside blood glucose concentration (BBGC) checks ±10 minutes of prespecified BBGC check according to the Brigham and Women's Hospital Intravenous Insulin Protocol (BHIP), was 47.2%. Seventy-two patients met inclusion criteria. Appropriate adjustment of infusion rates occurred 68.2% (1206/1768) of the time. Compliance with the timing of BBGC checks was found to be the majority of protocol violations. BBGCs were monitored ±5 minutes of indicated time per the protocol 26.2% (463/1768) of the time. Blood glucose concentration checks within extended timing of ±10 minutes of indicated time per the protocol occurred 793 (44.8%) times. Blood glucose concentration monitoring took place greater than 20 minutes past indicated time 450 (25.5%) times. In 1768 measurements, blood glucose concentrations between 40 and 60 mg/dL occurred 23 (1.3%) times in 12 (16.7%) patients. Blood glucose concentrations 40 mg/dL or less were detected 3 (0.17%) times in 2 (2.7%) patients. None of these hypoglycemic events led to documented complications. Conclusions: Overall, a rather low level of compliance with a paper-based, multiplication-factor, intravenous insulin protocol was observed, which warrants further investigation. Compliance rates in this evaluation were found to be similar to the rates observed in previously evaluated fixed-dose intravenous insulin protocols. Protocol noncompliance may be associated with hypo- and hyperglycemia.
Student–Teacher Relationship Stability Across Early School Years for Children With Intellectual Disability or Typical Development
Authors: Blacher Jan , Baker Bruce L. , Eisenhower Abbey S. 
Published: August 2009

AbstractStudent–teacher relationships of 37 children with moderate to borderline intellectual disability and 61 with typical cognitive development were assessed from child ages 6–8 years. Student–teacher relationship quality was moderately stable for the typical development group, but less so for the intellectual disability group. At each assessment these relationships were poorer for children with intellectual disability. Child behavior problems consistently predicted more conflict, whereas social skills predicted more closeness. Accounting for these child characteristics reduced the status group difference to nonsignificance. Earlier student–teacher relationships predicted subsequent changes in child behavior problems and social skills. Student–teacher relationships in the intellectual disability group were significantly lower for children in regular than special classes by age 8.
Field studies on deterrent properties of phlorotannins in Antarctic brown algae
Authors: Iken Katrin , Amsler Charles D. , Amsler Margaret O. , McClintock James B. , Baker Bill J. 
Published: August 2009

Abstract
Antiherbivore effects of phlorotannins from eight common Antarctic brown algae were tested with three omnivorous sympatric grazers, the fish Notothenia coriiceps, the sea star Odontaster validus, and the amphipod Gondogeneia antarctica. Incidence of grazing deterrence overall was relatively low, with only a few algal species deterring each of the grazers, and with phlorotannins from different algae active against different grazers. Most activity was found in Desmarestia menziesii and Cysto-sphaera jacquinotii, which deterred two out of the three grazers, while D. anceps and Himantothallus grandifolius deterred only one grazer type each. Only weak antimicrobial effects were detected in all phlorotannin extracts against four Antarctic bacterial strains, with phlorotannins of D. anceps and Phaeurus antarcticus having the strongest effects. Phlorotannin extracts of all brown algal species tested caused strong in vitro mortality in a fouling diatom. The ecological significance of this activity remains to be tested. While the bulk tissue phlorotannin concentrations likely overestimate naturally occurring surface concentrations encountered by foulers in situ, fouler settlement may be deterred at much lower concentrations than those eliciting mortality. Overall, Antarctic phlorotannin deterrent properties were specific both to the algal species as well as the grazer, bacteria and diatom taxa tested. For grazer deterrence, we propose that, for each of the tested grazers, complex interactions between phlorotannin chemical properties and grazer digestive characteristics may determine the effectiveness of specific phlorotannins. Larger generalizations of phlorotannin-grazer patterns such as distinction between meso- and macrograzers may not be valid, at least not for Antarctic brown algal phlorotannins.
Two polymorphs of 9-[(E)-2-(4-methylphenyl)ethenyl]-9H-carbazole, both with Z′ = 4
Authors: Kubicki Maciej , Prukala Wieslaw , Marciniec Bogdan 
Published: August 2009

Abstract
The crystal structures of two polymorphic forms of 9-[(E)-2-(4-methylphenyl)ethenyl]-9H-carbazole have been determined. One of the structures is monoclinic: P21, a = 10.627(2) Å, b = 30.475(5) Å, c = 10.671(3) Å, β = 118.60(2)°, and the other is triclinic: P-1, a = 10.6266(5) Å, b = 30.9003(13) Å, c = 10.6696(5) Å, α = 99.004(4)°, β = 118.683(4)°, γ = 87.852(3)°, and in both forms there are four symmetry-independent molecules in the asymmetric unit. The geometric parameters defining these molecules are similar with the normal probability plots showing that the differences between molecules are of a statistical rather than a systematic nature. In both structures there is a high degree of pseudo-symmetry between the symmetrically independent molecules. The crystal packing modes of both polymorphs are quite similar, the differences are found at the level of the composition of structural building blocks: stacks, layers and bi-layers.
Consistent approaches to van der Waals radii for the metallic elements
Authors: Hu Sheng-Zhi , Zhou Zhao-Hui , Robertson B. E. 
Published: August 2009

AbstractDue to the paucity of data on non-bonding interactions for metal atoms, no complete tabulation is available for crystallographic van der Waals radii for metallic elements. In this work several sets of van der Waals radii for metal atoms are derived indirectly. Unique data resources used for the derivation are (i) average volumes of elements in crystals, (ii) single covalent radii, (iii) Allinger´s van der Waals radii, as well as (iv) bond valence parameters formetal-oxygenbonds. The van der Waals radii for metal atoms deduced from these various approaches are basically comparable with each other, but are strikingly different from those from Bondi’s system of van der Waals radii. A complete set of new values for metallic elements up to Am, derived from bond valence parameters, are recommended.
Lipoatrophy in GH deficient patients treated with a long-acting pegylated GH
Authors: Touraine Philippe , D'Souza Gwyn A , Kourides Ione , Abs Roger , Barclay Paul , Xie Rujia , Pico Antonio , Torres-Vela Elena , Ekman Bertil 
Published: August 2009

ObjectiveChanges observed during adult GH deficiency (GHD) are most often reversed with the administration of recombinant human GH (rhGH). To avoid daily injections, a long-acting GH molecule has been obtained by covalent binding of polyethylene glycol (PEG) with rhGH (PEG–GH), allowing weekly s.c. injections. This study was designed to assess its efficacy and safety, in adult GHD subjects.Design and methodsThis was a randomized, double-blind, placebo-controlled, multiple-dose, parallel group study. Subjects were recruited from 34 centers. A total of 105 subjects with GHD were assigned a treatment. They received 6 weekly injections of either PEG–GH or placebo. Subjects were randomized into one out of four treatment groups (Groups A–D) or placebo (Group E). Groups A, B, and C received 1, 3, and 4 mg PEG–GH respectively, for the first 3 weeks followed by 2, 6, and 8 mg PEG–GH respectively, for the remaining 3 weeks. Group D received 4 mg PEG–GH for 6 weeks. Group E received placebo. The study was suspended because of the development of lipoatrophy in certain subjects and restarted with an injection rotation plan, before being terminated due to further subjects developing lipoatrophy.ResultsA total of 13 cases of injection-site lipoatrophy were reported, of which ten were in females and three occurred after the first injection; all cases were independent of PEG–GH dose or IGF1 levels, either basal or under treatment.ConclusionThe unpredictable occurrence of injection-site lipoatrophy with weekly long-acting pegylated GH molecules may be a limiting factor for their development.
Bioaccumulation of triclocarban in Lumbriculus variegatus
Authors: Higgins Christopher P. , Paesani Zachary J. , Chalew Talia E. Abbott , Halden Rolf U. 
Published: August 2009

Abstract
The antimicrobial triclocarban (TCC) has been detected in streams and municipal biosolids throughout the United States. In addition, TCC and potential TCC transformation products have been detected at high levels (ppm range) in sediments near major cities in the United States. Previous work has suggested that TCC is relatively stable in these environments, thereby raising concerns about the potential for bioaccumulation in sediment-dwelling organisms. Bioaccumulation of TCC from sediments was assessed using the freshwater oligochaete Lumbriculus variegatus. Worms were exposed to TCC in sediment spiked to 22.4 ppm to simulate the upper bound of environmental concentrations. Uptake from laboratory-spiked sediment was examined over 56 d for TCC and 4,4′-dichlorocarbanilide (DCC), a chemical impurity in and potential transformation product of TCC. The clearance of TCC from worms placed in clean sediment was also examined over 21 d after an initial 35-d exposure to TCC in laboratory-spiked sediment. Concentrations of TCC and DCC were monitored in the worms, sediment, and the overlying water using liquid chromatography/tandem mass spectrometry. Experimental data were fitted using a standard biodynamic model to generate uptake and elimination rate constants for TCC in L. variegatus. These rate constants were used to estimate steady-state lipid (lip)– and organic carbon (OC)– normalized biota-sediment accumulation factors (BSAFs) for TCC and DCC of 2.2 ± 0.2 and 0.3 ± 0.1 g OC/g lip (goc/glip), respectively. Alternatively, directly measured BSAFs for TCC and DCC after 56 d of exposure were 1.6 ± 0.6 and 0.5 ± 0.2 goc/glip, respectively. Loss of TCC from pre-exposed worms followed first-order kinetics, and the fitted elimination rate constant was identical to that determined from the uptake portion of the present study. Overall, study observations indicate that TCC bioaccumulates from sediments in a manner that is consistent with the traditional hydrophobic organic contaminant paradigm.