bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fostering public sector employees’ citizen-oriented boundary-spanning behaviors through human resource flexibility and employee perceptions of normative public values
Authors: Luu Trong Tuan 
Published: May 2024

Purpose Public sector employees’ contributions play a crucial role in improving public service quality and promoting the image of public organizations. The aim of this research is to unravel how and when human resource (HR) flexibility activates citizen-oriented boundary-spanning behaviors among public sector employees.Design/methodology/approach The data were collected from 427 public sector employees and 102 supervisors working for governmental agencies from the districts of a major city in Vietnam. Multilevel structural equation modeling (MSEM) was employed to analyze the data.Findings The positive associations between HR flexibility and the three dimensions of citizen-oriented boundary-spanning behaviors were supported. Harmonious passion demonstrated a mediating path for such linkages. Employee perceptions of normative public values were found to exert a positive moderating effect on the positive link between HR flexibility and harmonious passion, as well as their indirect link via harmonious passion.Originality/value This study advances the literature by identifying how and when HR flexibility shapes citizen-oriented boundary-spanning behaviors among public sector employees.
Insurance needs of digital nomads and predictions for future
Authors: Çetin Mesut 
Published: May 2024

PurposeThis study aims to determine the impact of digital nomadism on the relationship between tourism and traditional insurance models, the opportunities and challenges that digital nomadism brings to the insurance industry and future predictions.Design/methodology/approachA review approach was used, utilizing industry reports, statistics, market research and previous studies.FindingsDigital nomadism will directly bring about the development of personalized insurance products and services. The journey that began with digital health insurance will propel the industry to entirely new horizons.Originality/valueThe study offers a new perspective in this field by addressing the relationship between digital nomadism and the insurance industry.
Hydro‐modeling the ecosystem impact of wastewater reuse under climate change: A case study in upper Red River basin, Oklahoma
Authors: Gao Shang , Li Zhi , Graves Grant , Mattes Hannah A. , Fathollahifard Shadi , Vogel Jason , Neeson Thomas M. , Strevett Keith , Hong Yang 
Published: May 2024

AbstractWater reuse, as a viable option for water supply, must be implemented to minimize the adverse impacts on stream ecosystems that previously received this wastewater effluent. In the State of Oklahoma (OK), USA, local communities have implemented wastewater reuse, and many seek to expand the reuse programs. This study presents a hydro‐modeling analysis based on the Coupled Routing and Excess STorage with VECtor routing (CREST‐VEC) model focusing on the potential ecosystem impacts and societal benefits of wastewater reuse under climate change in the OK portion of the Red River basin. First, a CREST‐VEC model is established for the upper Red River basin and validated against observed streamflow for a 30‐year historical period (1990–2020). Based on the established model, we then assess the sensitivity of ecosystem impact to various climate change scenarios and hypothetical wastewater reuse scenarios. Results show that dominant effects of climate change cause the annual time below environmental flow to increase in the next 30 years, which constrains the room to implement wastewater reuse. However, at sub‐catchment scale, the analyses identify viable locations for allocating wastewater reuse while maintaining ecosystem health. The results also reveal that wastewater reuse brings about the most societal water benefits at minimal cost of ecosystem health under representative concentration pathway (RCP) 2.6 followed by RCP 4.5 and then RCP 8.5. Overall, the study demonstrates capabilities of the hydro‐modeling framework in developing water management plans facing the changing climate.
Is more better? A multilevel analysis of percutaneous coronary intervention hospital openings and closures on patient volumes
Authors: Hsia Renee Y. , Redberg Rita F. , Shen Yu‐Chu 
Published: May 2024

AbstractBackgroundIt is unknown how changes in the percutaneous coronary intervention (PCI) “built environment” have impacted PCI volumes at the community, hospital, and patient levels. This study sought to determine how PCI hospital openings and closures effect community‐ and hospital‐level PCI volumes as well as the likelihood of receiving PCI at a low‐volume hospital.MethodsWe conducted a retrospective cohort study of 3,966,025 Medicare Fee‐For‐Service patients in 37,451 zip codes and 2564 U.S. hospitals who underwent PCI from 2006 to 2017. We conducted community‐, hospital‐, and patient‐level analyses using ordinary least squares regressions with fixed effects to determine changes in PCI volumes after PCI hospital openings or closures.ResultsBetween 2006 and 2017, a total of 17% and 7% of patients lived in communities that experienced PCI hospital openings and closures, respectively. Openings were associated with a 10% increase in community PCI volume, a 2% increase in the share of elective PCI, and a doubling in the likelihood of receiving PCI at a low‐volume hospital. In communities with low baseline PCI capacity, openings were associated with a 12% increase in community PCI volume, and in high‐capacity communities, an 8% increase. PCI closures were associated with a 9% decrease in community PCI volume in high‐capacity communities but no measurable change in low‐capacity communities.ConclusionsPCI service expansion is associated with increased PCI at low‐volume hospitals and a greater number of elective procedures. Increased governmental oversight may be necessary to ensure that openings and closures of these specialized services yield the desired benefits.
Spraying for the beauty: Pesticide use for visual appearance in apple production
Authors: Zachmann Lucca , McCallum Chloe , Finger Robert 
Published: May 2024

AbstractPesticides are used to reduce yield losses and to enhance the visual quality of products. However, pesticide use raises concerns due to negative health and environmental effects, hence ambitious policy goals for their reduction have been established. Reducing pesticides which mainly focus on visual quality of products could be an efficient strategy to contribute to these goals, without reducing food production. However, the role of “cosmetic” pesticide use is so far not well documented and understood. Here, we quantify cosmetic pesticide use and the influence of supply chain characteristics on their use. We focus on table apple production, where the visual quality of products is a key aspect. Using a sample of 196 apple growers in Switzerland, we find that 23.5%–59.2% of growers use cosmetic pesticides for the apples’ visual appearance. Farms mainly marketing via intermediaries are 23.9‐29.6% more likely to spray cosmetic pesticides for visual purposes compared to farms mainly direct marketing. Our findings highlight the role of supply chains in farmer decision‐making, recommending a decrease in the focus on visual product quality, especially in retail environments, thus minimizing unnecessary and irreversible risks of pesticide exposure by farmers without compromising food security.
The mutated cytoplasmic fragile X messenger ribonucleoprotein 1 (FMR1)‐interacting protein 2 (CYFIP2 S968F) regulates cocaine‐induced reward behaviour and plasticity in the nucleus accumbens
Authors: Kim Young‐Jung , Kim Kyungin , Lee Youyoung , Min Hee‐Won , Ko Yong‐Hyun , Lee Bo‐Ram , Hur Kwang‐Hyun , Kim Seon‐Kyung , Lee Seok‐Yong , Jang Choon‐Gon 
Published: May 2024

Background and PurposeCytoplasmic fragile X messenger ribonucleoprotein 1 (FMR1)‐interacting protein 2 (CYFIP2), as a component of the Wiskott–Aldrich syndrome protein family verprolin‐homologous protein (WAVE) regulatory complex, is involved in actin polymerization, contributing to neuronal development and structural plasticity. Mutating serine‐968 to phenylalanine (S968F) in CYFIP2 causes an altered cocaine response in mice. The neuronal mechanisms underlying this response remain unknown.Experimental ApproachWe performed cocaine reward‐related behavioural tests and examined changes in synaptic protein phenotypes and neuronal morphology in the nucleus accumbens (NAc), using CYFIP2 S968F knock‐in mice to investigate the role of CYFIP2 in regulating cocaine reward.Key ResultsCYFIP2 S968F mutation attenuated cocaine‐induced behavioural sensitization and conditioned place preference. Cocaine‐induced c‐Fos was not observed in the NAc of CYFIP2 S968F knock‐in mice. However, c‐Fos induction was still evident in the medial prefrontal cortex (mPFC). CYFIP2 S968F mutation altered cocaine‐associated CYFIP2 signalling, glutamatergic protein expression and synaptic density in the NAc following cocaine exposure. To further determine the role of CYFIP2 in NAc neuronal activity and the mPFC projecting to the NAc activity‐mediating reward response, we used optogenetic tools to stimulate the NAc or mPFC‐NAc pathway and observed that optogenetic activation of the NAc or mPFC‐NAc pathway induced reward‐related behaviours. This effect was not observed in the S968F mutation in CYFIP2.Conclusion and ImplicationsThese results suggest that CYFIP2 plays a role in controlling cocaine‐mediated neuronal function and structural plasticity in the NAc, and that CYFIP2 could serve as a target for regulating cocaine reward.
The role of psychological distress in the relationship of financial strain with oral health and dental attendance in Dutch adults: A mediation analysis based on cross‐sectional data
Authors: Su Naichuan , Duijster Denise , van der Heijden Geert J. M. G. , Groeniger Joost Oude , Beenackers Mariëlle A. 
Published: May 2024

AbstractObjectivesThe study aimed to assess whether psychological distress mediates the association between financial strain and oral health and dental attendance in the Dutch adult population.MethodsThe study followed a cross‐sectional design based on 2812 participants from the 2014 wave of the Dutch population‐based GLOBE study. Financial strain was considered the exposure, while psychological distress measured with the Mental Health Inventory‐5 (MHI‐5) was the mediator. The outcomes included self‐reported number of teeth, self‐rated oral health, and self‐reported dental attendance. Generalized regression analyses were used for the mediation analysis adjusted for several covariables.ResultsGreater financial strain was significantly associated with poorer self‐rated oral health (total effect: 0.09, 95%CI: 0.05; 0.14) and restorative or no dental attendance (i.e. participants never visiting a dentist or only visiting a dentist for regular treatments or when they have complaints with their mouth, teeth, or prosthesis) (total effect: 0.05, 95%CI: 0.02; 0.09). Greater financial strain was not significantly associated with self‐reported number of teeth (total effect: −0.14, 95%CI: −0.91; 0.64). Psychological distress significantly mediated the association of financial strain with self‐rated oral health (average causal mediation effect [ACME]: 0.02, 95%CI: 0.01; 0.03) and self‐reported dental attendance (ACME: 0.01, 95%CI: 0.00; 0.02), respectively. However, it did not significantly mediate the association of financial strain with self‐reported number of teeth (ACME: −0.11, 95%CI: −0.25; 0.02). The estimated proportion of the total effect of financial strain on self‐rated oral health and self‐reported dental attendance that could be explained by psychological distress was respectively 24% (95%CI: 14%; 48%) and 19% (95%CI: 6%; 62%).ConclusionsPsychological distress partly explains the association of financial strain with self‐rated oral health and dental attendance, but not with self‐reported number of teeth. Future studies using longitudinal data are necessary to confirm the results.
Effects of gut microbiome on type 1 diabetes susceptibility and complications: A large‐scale bidirectional Mendelian randomization and external validation study
Authors: Guo Keyu , Ye Jianan , Li Jiaqi , Huang Juan , Zhou Zhiguang 
Published: May 2024

AbstractAimTo assess and verify the effect of the gut microbiome on the susceptibility and complications of type 1 diabetes (T1D).Materials and MethodsTo achieve this aim, a two‐sample and reverse Mendelian randomization (MR) analysis was conducted. In addition, an external validation study was performed using individual microbiome data of patients with T1D from the gutMEGA datasets and the National Clinical Research Center for Metabolic Diseases. The circulating metabolites facilitated two‐sample MR analysis, mediation and multivariable MR analysis to evaluate the direct relationship between the gut microbiome and T1D complications.ResultsThe MR analysis results from the discovery and validation phases confirmed that Veillonellaceae can potentially reduce the susceptibility of T1D. In the gutMEGA dataset, the average relative abundance of Veillonellaceae in patients with T1D was 0.66%, compared with 1.09% in the controls. Furthermore, the external validation, which included 60 patients with T1D and 30 matched healthy controls, found that the median relative abundance of Veillonellaceae was also lower than controls at 1.10% (95% CI 0.50%‐1.80%). Specifically, the Eubacterium coprostanoligenes group, known for its ability to regulate cholesterol, was significantly associated with a lower risk of developing renal, neurological and ophthalmic complications in T1D. Moreover, high cholesterol in small high‐density lipoprotein and cholesteryl esters in high‐density lipoprotein were associated with a reduced risk of T1D renal and ophthalmic complications. The mediation and multivariable MR analysis combining cholesterol indicated that the E. coprostanoligenes group is the most dominant factor influencing T1D complications.ConclusionsOur findings supported the potential causal effect of gut microbiota on the susceptibility and complications of T1D.
Guillain‐Barré syndrome: History, pathogenesis, treatment, and future directions
Authors: Hughes Richard A. C. 
Published: May 2024

AbstractBackground and purposeSince its description by Guillain, Barré, and Strohl in 1916, Guillain–Barré syndrome (GBS) has attracted a large literature. The author reviews the history of research into its pathogenesis and treatment to highlight promising avenues for future research.MethodsThis is a nonsystematic personal review.ResultsSince the early 1900s, the clinical picture of GBS has been illustrated in multiple series culminating in the ongoing International Guillain–Barré Syndrome study of 2000 patients. In the 1950s and 1960s, the inflammatory nature of the commonest form, acute inflammatory demyelinating polyradiculoneuropathy (AIDP), was described. In the 1990s, two axonal forms, acute motor–sensory axonal neuropathy and acute motor axonal neuropathy, were recognized. In the 1990s and early 2000s, these forms were shown to be due to antibodies against Campylobacter jejuni glycans cross‐reacting with glycolipids on axonal membranes. The pathogenesis of AIDP remains unknown, but T‐cell responses to the compact myelin proteins, P2 and P0, which cause experimental autoimmune neuritis, suggest that T cells are important. Randomized controlled trials in the 1970s and 1980s showed no benefit from corticosteroids. Trials in the 1980s showed benefit from plasma exchange and in the 1990s from intravenous immunoglobulin.ConclusionsFuture research should seek biomarkers to identify subgroups with different treatment responses, define the true natural history of the disease with population‐based epidemiological studies, study the pathology in autopsies early in the disease, seek causative antibodies and confirm autoimmune T‐cell responses in AIDP, and expand treatment trials to include anti‐T‐cell agents.
FADD gene pathogenic variants causing recurrent febrile infection‐related epilepsy syndrome: Case report and literature review
Authors: Giovannini Giada , Giannoccaro Maria Pia , Cioclu Maria Cristina , Orlandi Niccolò , Liguori Rocco , Meletti Stefano 
Published: May 2024

AbstractFIRES and NORSE are clinical presentations of disease processes that, to date, remain unexplained without an established etiology in many cases. Neuroinflammation is thought to have paramount importance in the genesis of these conditions. We hereby report the clinical, EEG, brain MRI, and genetic findings of a nuclear family with recurrent febrile‐related encephalopathy with refractory de novo Status Epilepticus. Whole‐exome sequencing (WES) revealed a homozygous p.C105W pathogenic variant of FADD gene (FAS‐associated protein with death domain, FADD), known to cause ultrarare forms of autosomal recessive immunodeficiency that could be associated with variable degrees of lymphoproliferation, cerebral atrophy, and cardiac abnormalities. The FADD‐related conditions disrupt FAS‐mediated apoptosis and can cause a clinical picture with the characteristics of FIRES. This observation is important because, on one hand, it increases the number of reported patients with FADD deficiency, showing that this disorder may present variable expressivity, and on the other hand, it demonstrates a genetic cause of FIRES involving a cell‐mediated inflammation regulatory pathway. This finding supports early treatment with immunomodulatory therapy and could represent a new avenue of research in the field of new onset refractory status epilepticus and related conditions.
Parenting beliefs and practices as precursors to academic outcomes in Chinese children
Authors: Ren Lixin , Chen Mengdi , Hu Bi Ying , Sun Jin 
Published: May 2024

AbstractDue to the rapid sociocultural changes in China, Chinese parents' childrearing beliefs and practices have undergone dramatic transformations. Against this context, this study examined whether Chinese parents' endorsement of progressive and traditional childrearing beliefs would predict children's academic achievement, as well as whether parenting practices would mediate this association. This study utilized a longitudinal design and followed 206 Chinese families for 2 years from the end of preschool to Grade 2. Parents showed greater endorsement of progressive than traditional childrearing beliefs, as well as higher use of authoritative than authoritarian parenting practices. Parents' childrearing beliefs in preschool predicted children's math achievement in Grade 2 via authoritative parenting. However, parenting beliefs were unrelated to authoritarian parenting, and authoritarian parenting did not predict any of the child academic outcomes in Grade 2. The findings suggest Chinese parents' orientations toward progressive parenting beliefs and authoritative parenting practices. They also highlight the utility of parenting beliefs in explaining disparities in early academic achievement. The nonsignificant findings pertinent to authoritarian parenting call for re‐examination of the cultural meaning and effects of authoritarian parenting in Chinese society.
Do more egalitarian men experience less union dissolution? A couple‐level analysis
Authors: Raz‐Yurovich Liat , Okun Barbara S. , Ben‐Avi Matanel 
Published: May 2024

AbstractObjectiveWe consider whether heterosexual unions in which male partners are more gender egalitarian experience less union dissolution.BackgroundGender revolution theory argues that as men become more egalitarian in their attitudes and behaviors, female partners experience reduced work–family conflict, and couples enjoy more stable partnerships. In contrast, the “flip side” perspective argues that consequences of men's increased egalitarian behavior for their own experience of role incompatibility may counterbalance effects on union stability.MethodAnalyzing a sample of roughly 46,600 women‐years from the British Household Panel Survey and Understanding Society (1993–2019), we estimate random‐intercept and fixed‐effects models of union dissolution. Explanatory variables include, for each partner, measures of egalitarianism in gender role attitudes and weekly housework hours.ResultsOdds of union dissolution are not associated with men's absolute level of egalitarian attitudes, but they are higher when men's attitudes are less egalitarian than their partner's. Neither the absolute number of men's housework hours, nor their share of total housework, is associated with the odds of dissolution.ConclusionsOur findings are not generally supportive of gender revolution theory. Counterbalancing effects may provide an explanation for the findings, as per the flip side approach.ImplicationsTaking a couple‐level perspective advances understanding of the associations between gender egalitarianism and union dissolution.
The impact of social distancing on trading activity during the COVID‐19 pandemic
Authors: Sabah Nasim 
Published: May 2024

AbstractI explore the impact of social distancing on trading activity during the COVID‐19 pandemic using real‐time location tracking data from Facebook users. I find that stocks categorized as “harder‐to‐value,” which are typically smaller, less transparent, less visible, and less profitable, experience decreased abnormal trading with more social distancing in their headquarters counties. In contrast, “easier‐to‐value” stocks show an increase in abnormal trading due to high social distancing in their headquarters counties. These findings indicate that greater firm‐specific information asymmetry arises from increased social distancing within the firm headquarters counties. Although “easier‐to‐value” stocks can use alternative information sources to mitigate the information asymmetry, “harder‐to‐value” stocks fail to do so and face negative impact on trading. Additional analyses using alternative information channels, market sidedness, and liquidity confirm this hypothesis.