bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of Vertical Permeability in the McMurray Formation
Authors: Deutsch C.V. 
Published: November 2010

Summary
Predicting the performance of in-situ recovery processes in the McMurray formation is required to optimize development planning and resource management. These performance predictions are sensitive to many parameters; however, vertical permeability is perhaps the most critical geological parameter. There are many challenges associated with the estimation of vertical permeability: (1) it is difficult to collect representative core measurements, (2) the high viscosity of the bitumen makes it impossible to perform well testing, (3) statistical approaches and the notion of representative elementary volumes (REVs) are challenged by heterogeneities at all scales and (4) the nature of the heterogeneities is variable within different depositional environments. This paper summarizes these challenges, then presents a consistent numerical modelling framework based on core data, core photographs, conventional well-logs, high-resolution image logs and detailed geological interpretation. The framework includes: dividing the stratigraphic column into facies with similar spatial arrangement of sand/shale, constructing high-resolution models of sand/shale, assigning porosity and permeability to sand/shale, calibrating the models to direct measurements, solving for effective horizontal and vertical permeability at the appropriate scale and transferring the results to geomodelling. This framework is described in detail and demonstrated with illustrative examples. Considerations for even better results are discussed.
Drilling Challenges in the Bitumen-Saturated Grosmont Formation
Authors: Arseniuk Stephen E. , Becker D.L. , Barrett Kent R. , Keller Derek 
Published: November 2010

Summary
The Upper Devonian Grosmont formation, located in the West Athabasca oil sands deposit, contains an estimated 318 billion barrels of bitumen. The reservoir is a heavily karsted and fractured, bitumen-saturated dolomite with up to 38% porosity and permeabilities commonly measured in the darcies. These properties make the Grosmont an excellent candidate for steam assisted gravity drainage (SAGD). Grosmont SAGD development will be exposed to similar operating conditions as McMurray SAGD projects, and will have similar logistics, well construction and materials challenges. However, there are many additional challenges, including severe loss circulation, that further complicate well design. This paper presents the challenges experienced by Laricina Energy in drilling Grosmont wells at Saleski and Burnt Lakes over the last three seasons. It will also address additional areas for future research and development in the drilling of vertical and horizontal wells.
Motivation to Provide Help to Older Parents in Norway, Spain, and Israel
Authors: Katz Ruth , Gur-Yaish Nurit , Lowenstein Ariela 
Published: November 2010

We explore from a cross-national perspective three motivations in adult children to provide help to older parents: affectual solidarity, parental need for care, and filial norms. The sample is 1,055 adult children from Norway, Spain, and Israel, countries selected because they represent different family cultures and welfare regimes. Affectual solidarity and parental need for care was found to influence amount of help in all three countries, whereas filial norms was found to have no effect. Country context had a differential impact. In Israel, affectual solidarity was more strongly associated with amount of help. In Israel and Norway, parents' need for care was related to amount of help; in Spain help provided was high, regardless of parents' need for care. We demonstrate the universality of motivations to provide help to older parents and the influence of cultural context on these motivations, taking into account within-country differences.
Effluent Volume in Continuous Renal Replacement Therapy Overestimates the Delivered Dose of Dialysis
Authors: Claure-Del Granado Rolando , Macedo Etienne , Chertow Glenn M. , Soroko Sharon , Himmelfarb Jonathan , Ikizler T. Alp , Paganini Emil P. , Mehta Ravindra L. 
Published: November 2010

Summary

Background and objectives
Studies examining dose of continuous renal replacement therapy (CRRT) and outcomes have yielded conflicting results. Most studies considered the prescribed dose as the effluent rate represented by ml/kg per hour and reported this volume as a surrogate of solute removal. Because filter fouling can reduce the efficacy of solute clearance, the actual delivered dose may be substantially lower than the observed effluent rate.

Design, setting, participants, & measurements
Data were examined from 52 critically ill patients with acute kidney injury (AKI) requiring dialysis. All patients were treated with predilution continuous venovenous hemodiafiltration (CVVHDF) and regional citrate anticoagulation. Filter performance was monitored during the entire course of therapy by measuring blood urea nitrogen (BUN) and dialysis fluid urea nitrogen (FUN) at initiation and every 12 hours. Filter efficacy was assessed by calculating FUN/BUN ratios every 12 hours of filter use. Prescribed urea clearance (K, ml/min) was determined from the effluent rate. Actual delivered urea clearance was determined using dialysis-side measurements.

Results
Median daily treatment time was 1413 minutes (1260 to 1440) with a total effluent volume of 46.4 ± 17.4 L and urea mass removal of 13.0 ± 7.6 mg/min. Prescribed clearance overestimated the actual delivered clearance by 23.8%. This gap between prescribed and delivered clearance was related to the decrease in filter function assessed by the FUN/BUN ratio.

Conclusions
Effluent volume significantly overestimates delivered dose of small solutes in CRRT. To assess adequacy of CRRT, solute clearance should be measured rather than estimated by the effluent volume.
Cystatin C Reduction Ratio Depends on Normalized Blood Liters Processed and Fluid Removal during Hemodialysis
Authors: Huang Shih-Han S. , Filler Guido , Yasin Abeer , Lindsay Robert M. 
Published: November 2010

Summary

Background and objectives
A negative correlation between the weekly standard Kt/V (urea) and serum cystatin C level (CysC) in functionally anephric dialysis patients has been previously demonstrated. Our objective was to measure the per dialysis CysC reduction ratio (CCRR) and to compare it with other indices of dialytic functions.

Design, setting, participants, & measurements
In a pilot cross-sectional study of 15 functionally anephric patients on conventional high-flux high-efficiency hemodialysis three times per week, CysC levels were drawn pre-, mid-, and postdialysis over 1 week. CCRR was compared with single-pool Kt/V (Sp Kt/V) using urea kinetic modeling, urea reduction ratio (URR), creatinine reduction ratio (CRR), normalized liters processed (LP/kg), and ultrafiltration volume (UF). Normally distributed data (Shapiro-Wilks test) were described as mean ± SD, otherwise as median and interquartile range.

Results
The mean pre- and post-CysC levels were 6.0 ± 1.0 and 4.7 ± 1.1 mg/L. The Sp Kt/V and Std Kt/V were 1.5 ± 0.2 and 2.6. The URR, CRR, and CCRR were 70.2% ± 9.0%, 64.5% ± 8.2%, and 26.1% ± 11.8%, respectively. There was no correlation between the CCRR, and the Sp Kt/V, URR, and CRR, whereas CCRR correlated with LP/kg and UF. Multiple regression analysis with these two parameters provided a model that explained 81% of the variance.

Conclusions
Our data suggest that normalized liters processed and ultrafiltration volume explain most of the variance of CCRR. Therefore, CCRR may be an excellent method to monitor dialysis efficiency of low molecular weight proteins.
Systemic Consequences of Poor Oral Health in Chronic Kidney Disease Patients
Authors: Akar Harun , Akar Gulcan Coskun , Carrero Juan Jesús , Stenvinkel Peter , Lindholm Bengt 
Published: November 2010

Summary
Changes in the oral cavity, such as periodontitis and other manifestations of poor oral health, are common in patients with chronic kidney disease (CKD) and may contribute to increased morbidity and mortality because of systemic consequences such as inflammation, infections, protein-energy wasting, and atherosclerotic complications. Poor oral health in CKD patients may thus represent an important, but often overlooked, problem. Several studies show that uremic patients have higher rates of decayed, missing, and filled teeth, loss of attachment, and periapical and mucosal lesions than the general population. The consequences of poor oral health may be more severe in CKD patients because of advanced age, common comorbidities such as diabetes, concurrent medications, and a state of immune dysfunction that may increase the risk for systemic consequences of periodontitis and other oral and dental pathologic conditions. Poor dentition and other signs of poor oral health should be an alarm clock also at early stages of CKD. However, it remains to be determined whether more successful management of poor oral health and periodontitis will reduce the risk of inflammation, infection, protein-energy wasting, and atherosclerotic complications in CKD patients. This review explores etiological factors and potential systemic consequences of poor oral health in CKD patients as well as possible preventive and therapeutic strategies.
Peritoneal Dialysis First
Authors: Chaudhary Kunal , Sangha Harbaksh , Khanna Ramesh 
Published: November 2010

Summary
The use of peritoneal dialysis (PD) has become wide spread since the introduction of continuous ambulatory PD more than 25 years ago. Over this time, many advances have been made and PD is an alternative to hemodialysis (HD), with excellent comparable survival, lower cost, and improved quality of life. The percentage of prevalent PD patients in the United States is approximately 7%, which is significantly lower compared with the 15% PD prevalence from the mid-1980s. Despite comparable survival of HD and PD and improved PD technique survival over the last few years, the percentage of patients performing PD in the United States has declined. The increased numbers of in-center HD units, physician comfort with the modality, perceived superiority of HD, and reimbursement incentives have all contributed to the underutilization of PD. In addition to a higher transplantation rate among patients treated with PD in the United States, an important reason for the low PD prevalence is the transfer to HD. There are various reasons for the transfer (e.g., episodes of peritonitis, membrane failure, patient fatigue, etc.). This review discusses the various factors that contribute to PD underutilization and the rationale and strategies to implement “PD first” and how to maintain it. The PD first concept implies that when feasible, PD should be offered as the first dialysis modality. This concept of PD first and HD second must not be seen as a competition between therapies, but rather that they are complementary, keeping in mind the long-term goals for the patient.
Expression of Extracellular Matrix Metalloproteinase Inducer in Nasal Polyps
Authors: Lee Jang-Hyeog , Chung Seung Won , Park Il-Ho , Lee Sang Hag , Lee Seung Hoon , Lee Heung-Man 
Published: November 2010

Background Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. The presence of EMMPRIN in nontumoral tissues suggests a role in other physiological and pathological situations, which may be associated with increased matrix metalloproteinase expression. The purpose of this study was to investigate the expression of EMMPRIN mRNA (OMIM *606080) and to localize the EMMPRIN protein in nasal polyps and healthy nasal mucosa. Methods The expression of EMMPRIN was investigated in the nasal polyps of 10 patients undergoing endonasal sinus surgery and compared with nasal mucosal samples obtained from 10 healthy controls. EMMPRIN mRNA was extracted from the tissues, and then a reverse transcription–polymerase chain reaction was performed. Western blot analysis was used to analyze differences in the levels of expression of EMMPRIN protein between patients with nasal polyps and healthy controls, and the EMMPRIN protein was localized in immunohistochemical staining and quantitative analysis of immunopositivity. Results The levels of expression of EMMPRIN mRNA and protein were significantly increased in patients with nasal polyps compared with healthy controls. EMMPRIN protein was expressed in the epithelium and infiltrating inflammatory cells of nasal polyps and the healthy nasal mucosa. The percentages of the immune-stained area and the number of EMMPRIN-immunopositive inflammatory cells per millimeter were significantly elevated in nasal polyps compared with controls. Conclusion EMMPRIN is expressed in nasal mucosa and in nasal polyps, and the level of EMMPRIN expression is increased in nasal polyps. These results suggest that the increased expression of EMMPRIN may play a role in the pathogenesis of nasal polyps.
Video-Rhino-Hygrometer: A New Method for Evaluation of Nasal Breathing after Nasal Surgery
Authors: Casale Manuele , Pappacena Marco , Setola Roberto , Soda Paolo , Cusimano Valerio , Vitali Massimiliano , Mladina Ranko , Salvinelli Fabrizio 
Published: November 2010

Background Nasal obstruction is one of the most frequent symptoms in the ear, nose, and throat (ENT) setting. It can be evaluated either subjectively or objectively. In a subjective way, a visual analog scale (VAS) and the Sino-Nasal Outcome Test 20 (SNOT 20) can rapidly quantify the degree of obstruction, whereas the most commonly used objective methods are nasal endoscopy and active anterior rhinomanometry (AAR). It is still a matter of controversy to what extent the sense of nasal obstruction is associated with objective measures for nasal space and airflow. The aim of the study was to evaluate nasal breathing before and after functional nasal surgery by video-rhino-hygrometer (VRH) comparing the results with widely accepted methods. Methods Twenty patient candidates for septoplasty and inferior turbinate reduction were included in the study. SNOT-20, VAS, nasal endoscopy, and AAR were analyzed and compared with VRH values. Results Before surgery VRH showed variability of nasal respiratory flow between individuals and between nostrils. After surgery we had an increase (p < 0.05) of airflow in both nostrils. VRH data were found to be correlated with VAS and SNOT-20 values (p < 0.05) both pre- and postoperatively. Despite the statistically significant correlation of AAR with SNOT-20 and VAS, no statistically significant correlation between AAR and VRH was found. Conclusion VRH provides an immediate, easy, and noninvasive assessment of nasal respiration. For these reasons it can be used, in association with rhinoscopic data and other instrumental tests, to evaluate nasal breathing in daily ENT practice.
The Diagnosis of Food Allergy
Authors: Lieberman Jay A. , Sicherer Scott H. 
Published: November 2010

Background Food allergy is increasingly common; however, there is a discrepancy between the large number of people who believe they or their children are affected and the actual number with true food allergies. It is therefore imperative that physicians evaluating patients with possible adverse reactions to foods understand the current modalities used to diagnose food allergies. Methods Simple tests including skin-prick testing (SPT) and serum food-specific IgE testing are the most commonly used diagnostic tests to evaluate for IgE-mediated food reactions. However, these tests have pitfalls and their usefulness must be appreciated to avoid over- and underdiagnosis. Results A firm diagnosis is imperative because a misdiagnosis could lead to life-threatening reactions and overdiagnosis will lead to unnecessary elimination diets with nutritional and social implications. Physician-supervised oral food challenges (OFC) remain the gold standard for food allergy diagnosis; however, a careful medical history and simple tests can often provide a reliable diagnosis. Conclusion In this review, we examine the usefulness and pitfalls of SPT used by allergists and serum food-specific IgE levels that are available to all practitioners. We also review the OFC as a diagnostic modality in food allergy. Finally, we describe emerging tests, such as the basophil activation test, atopy patch testing, and component-resolved diagnostics, that may be of benefit in the future.
Factors Affecting Outcome of Inferior Turbinate Mucotomy in Treatment of Postnasal Drip Syndrome
Authors: Zagólski Olaf 
Published: November 2010

Background Postnasal drip syndrome may result from isolated hyperplasia of nasal inferior turbinates due to chronic rhinitis. Mucotomy (conchotomy) performed in such patients is generally effective but in some individuals the problem persists after surgery. Objective The aim of this study was to determine factors influencing outcome of the therapy. Methods One hundred six patients aged 17–60 years (mean = 34, SD = 12) with hyperplasia of the inferior turbinates underwent bipolar diathermy mucotomy. Nonallergic noninfectious rhinitis was diagnosed in 18, neutrophilic in 58, allergic in 18 and NARES in 14 patients. The participants were questioned about postnasal drip (PND) intensity before and 2 months after surgery. Results Results of mucotomy significantly depended on the etiology of chronic rhinitis and were worst in patients with NARES (p < 0.05). Percent values of reduction of PND intensity after mucotomy and percent of daytime with PND persisting after surgery depended on Staphylococcus aureus colonization of the nose (the results were worse in patients with the colonization, p < 0.001). Satisfaction scores were also dependent on S. aureus nasal colonization (p < 0.001) and significantly correlated with percent values of subjective reduction of PND intensity after surgery (p < 0.001) and reduction of PND daily duration (p < 0.001). Conclusions Results of mucotomy performed for postnasal drip depend on etiology of rhinitis and are worse in S. aureus nasal colonization.
High Prevalence of Humoral Immunodeficiency Patients with Refractory Chronic Rhinosinusitis
Authors: Alqudah Mohannad , Graham Scott M. , Ballas Zuhair K. 
Published: November 2010

Background The purpose of this study was to investigate the prevalence and contribution of humoral immunodeficiency in refractory chronic rhinosinusitis (RCRS). This study was performed at a tertiary care academic referral center. Methods RCRS patients who had at least three episodes of documented sinusitis in the previous year despite antibiotic therapy, who had endoscopic sinus surgery performed at University of Iowa Health Care (UIHC), and who were evaluated by the UIHC Adult Immune Disorder Clinic were included. Exclusion criteria included allergic fungal sinusitis, human immunodeficiency virus, and other causes of secondary immunodeficiency. Sixty-seven patients fulfilled the inclusion and exclusion criteria. The results of their immunologic evaluation for atopy and humoral immune function were examined. Results The average age of these patients was 50 years (±11.6 years). Twenty-eight (42%) patients had at least one positive result on allergy skin testing. Determination of quantitative immunoglobulins showed low IgG in 9%, low IgA in 3%, and low IgM in 12% of patients. Common variable immunodeficiency was diagnosed in one case. Immunoglobulin G subclasses were tested in 31 cases and found low in 6 patients. Fifty-one patients underwent a dynamic assessment of their antibody response by examining the increase in antibody titer to an unconjugated pneumococcal polysaccharide vaccine. Sixty-seven percent of patients failed to produce more than a fourfold increase in postimmunization antibody titer for >7 of 14 serotypes being tested and were considered to have functional antibody deficiency. Conclusion This retrospective review shows an unexpectedly high prevalence of humoral immune dysfunction in patients with RCRS. These findings suggest that assessment of immune function should be undertaken routinely in RCRS. Immune assessment should first include measurement of serum immunoglobulin levels; if these are normal, then functional antibody responses should be evaluated.
Distinctions between Allergic Fungal Rhinosinusitis and Chronic Rhinosinusitis
Authors: Hutcheson Patricia S. , Schubert Mark S. , Slavin Raymond G. 
Published: November 2010

Background Recent reports have attempted to redefine the accepted diagnostic criteria for allergic fungal rhinosinusitis (AFRS), a form of chronic rhinosinusitis (CRS) with nasal polyps. As a result, the existence of AFRS as a distinct entity has been questioned, suggesting that allergy has no role in CRS with sinonasal eosinophilia, and the condition should be referred to as eosinophilic fungal rhinosinusitis. The purpose of the study was to differentiate between AFRS and CRS by studying antibody responses in these two clearly defined patient groups. Methods Ninety-nine patients were enrolled and classified as AFRS or CRS (without AFRS). Serum total IgE, IgG anti–Alternaria-specific antibodies (UniCAP 100), and IgE antifungal antibodies (immunoblotting) were compared between the groups. Results Sixty-four patients fit the traditional criteria for AFRS, with 35 as CRS. Mean serum total IgE and mean IgG anti–Alternaria-specific antibodies were statistically significantly increased in AFRS over CRS patients. There was also a statistically significant increase in the mean number of IgE antifungal bands from AFRS compared with CRS patients. Conclusion We have shown a clear immunologic difference between AFRS and CRS patients. The overwhelming evidence of increased total IgE and fungal-specific IgE in AFRS supports an allergic component in AFRS. IgG anti–Alternaria-specific antibodies also point to an exaggerated fungal immune response in these patients. These results support the existence of AFRS as a separate, distinct entity of CRS. It is important to recognize AFRS to ensure proper treatment in these patients.
Fluticasone Furoate Nasal Spray is Effective and Well Tolerated for Perennial Allergic Rhinitis in Adolescents and Adults
Authors: Given John T. , Cheema Amarjit S. , Dreykluft Tilman , Stillerman Allan , Silvey MaryJane , Wu Wei , Snowise Neil G. , Philpot Edward 
Published: November 2010

Background Fluticasone furoate nasal spray (FFNS), an intranasal corticosteroid, has been shown to be effective in perennial allergic rhinitis in randomized, double-blind, placebo-controlled studies but has been less extensively studied in perennial allergic rhinitis than seasonal allergic rhinitis. This study was designed to evaluate the efficacy and safety of FFNS in perennial allergic rhinitis in adolescents and adults ≥12 years of age. Methods In this randomized, double-blind, placebo-controlled, parallel-group study (FFU111439), patients ≥12 years old with perennial allergic rhinitis received FFNS, 110 micrograms (n = 160), or placebo (n = 155) q.d. for 4 weeks. Results Over the entire treatment period, FFNS was significantly (p < 0.05) more effective than placebo with respect to mean changes from baseline in daily reflective total nasal symptoms (primary end point), morning and evening reflective total nasal symptoms, daily reflective individual nasal symptoms, morning predose instantaneous total and individual nasal symptoms, and morning and evening peak nasal inspiratory flow. FFNS did not show a statistically significant difference from placebo in comparisons of ocular symptom measures. Clinically meaningful improvement versus placebo was observed on the Rhinoconjunctivitis Quality of Life Questionnaire with Standardised Activities overall score. Adverse events reported in >3% of patients in a treatment group and reported more frequently with FFNS than placebo were epistaxis (15% FFNS, 8% placebo) and nasopharyngitis (5% FFNS, 1% placebo). Conclusion Once-daily FFNS was well tolerated and more effective than placebo at improving nasal symptoms of perennial allergic rhinitis in adolescents and adults ≥12 years of age.