bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular Reconstruction During Pancreatoduodenectomy for Ductal Adenocarcinoma of the Pancreas Improves Resectability but does not Achieve Cure
Authors: Ouaissi Mehdi , Hubert Catherine , Verhelst Robert , Astarci Parla , Sempoux Christine , Jouret‐Mourin Anne , Loundou Anderson , Gigot Jean‐François ,   The Multidisciplary HPB Group of Center of Cancer
Published: July 2010

AbstractObjectiveCombined vascular and pancreatic resection improves long‐term survival of patients suffering from ductal adenocarcinoma of the pancreatic head. This study was designed to compare the results of surgical resection in patients with pancreatic cancer with or without vascular resection. Late 10‐year disease‐free survival was considered as an indicator of patients’ disease cure.MethodsA total of 149 consecutive patients have undergone pancreatoduodenectomy without vascular resection (group 1: 82 patients), with isolated venous resection (group B: 67 patients), or with arterial and/or venous resection (group C: 8 patients).ResultsThe duration of surgery and blood losses were significantly more important in groups B and C compared with group A; however, postoperative morbidity and mortality rates were similar. R1 resection was significantly more frequent in groups B (42%) and C (50%) compared with group A (13%; p = 0.0002), but there were more advanced tumors in these groups, as demonstrated by a lower Karnowsky index, higher Ca 19‐9 plasmatic level, greater tumor size, more advanced stage in the AJCC classification, and more tumor location in the uncinate process of the pancreas. Ten‐year overall and disease‐free survivals were significantly better in group A (19 and 20%) compared with group B (2.8 and 0%) and group C (0% and 0%). Multivariate analysis proved vascular resection and metastatic nodal status as being independent predictive factors of disease‐free survival.ConclusionsVascular resection combined to pancreatoduodenectomy for pancreatic cancer increases local resectability without increasing mortality and morbidity rates but does not improve patients’ disease cure rate.
Uterine massage to reduce postpartum hemorrhage after vaginal delivery
Authors: Abdel‐Aleem Hany , Singata Mandisa , Abdel‐Aleem Mahmoud , Mshweshwe Nolundi , Williams Xoliswa , Hofmeyr G. Justus 
Published: July 2010

AbstractObjectiveTo determine the effectiveness of sustained uterine massage started before delivery of the placenta in reducing postpartum hemorrhage.MethodsA randomized controlled trial conducted in Egypt and South Africa between September 2006 and February 2009. A total of 1964 pregnant women were randomly allocated to 1 of 3 treatment groups: intramuscular oxytocin, sustained uterine massage, or both treatments. Blood loss within 30 minutes of delivery was recorded.ResultsThe incidence of blood loss of 300 mL or more within 30 minutes of delivery was significantly higher in the massage group than in the massage plus oxytocin (RR 1.88; 95% CI, 1.29–2.74 in Assiut, and RR 1.3; 95% CI, 1.00–1.68 in SA) and the oxytocin only group (RR 1.7; 95% CI, 1.11–2.61 in Assiut, and RR 2.24; 95% CI, 1.54–3.27 in SA). In both centers, use of additional uterotonics was significantly higher in the uterine massage group compared with the other 2 groups.ConclusionUterine massage was less effective than oxytocin for reducing blood loss after delivery. When oxytocin was used, there was no additional benefit from uterine massage. The effectiveness of uterine massage in the absence of oxytocin was not studied. ACTRN: 12609000372280.
Spatially variable sedimentary responses to orbitally driven pluvial climate during Marine Oxygen Isotope Stage 5.1, Dakhla Oasis region, Egypt
Authors: Brookes Ian A. 
Published: July 2010

AbstractPleistocene basinal sediments (PBS) in the Dakhla region of Egypt's hyperarid Western Desert comprise four facies: (A) fluvio-lacustrine, (B) mixed lacustrine/pluvio-eolian, (C) pluvio-eolian, and (D) mixed eolian/pluvio-eolian. Contiguity of basins containing each facies, and their stratigraphic position between two bajada gravel formations, P/B-II and P/B-III, confirm their equivalence. Facies A and B, with lacustrine components, are attributed to orbitally forced poleward incursion of the Intertropical Convergence Zone (ITCZ), resulting in increased summer insolation/temperature/precipitation. Facies C and D, comprising pluvio-eolian and eolian sediments, reflect geologic/topographic influences overprinted on regional 'pluvial' conditions, eliminating lacustrine response. A Th/U age of ∼ 62 ka on lacustrine marl within Facies B is minimal, and an OSL age of 110 ± 18 ka on sediments immediately below Facies B is maximal. Since bajada gravels P/B-III are the youngest Pleistocene formation, they must represent the final strong incursion of the ITCZ into the Dakhla region at MIS 5.1, ∼ 80 ka. Because PBS Facies A pass rapidly up into P/B-III bajada gravels, PBS are assigned to the rising limb of the MIS 5.1 insolation/temperature/precipitation curve, slightly younger than 80 ka.
Assessment of early post-operative pain following septorhinoplasty
Authors: Szychta P , Antoszewski B 
Published: July 2010

AbstractObjective:To evaluate pain incidence and intensity in patients undergoing septorhinoplasty, and to assess analgesic treatment effectiveness, in the first 7 days after surgery.Design:Prospective outcomes analysis using visual analogue scale assessment of pain intensity in the first 7 post-operative days.Subjects:Fifty-seven patients were enrolled in the study, 29 women and 28 men, aged 18 to 51 years. All were treated for post-traumatic deformity of the external nose and/or nasal septum, with either septorhinoplasty or septoplasty.Results:In the first 3 days after septorhinoplasty, patients' mean visual analogue scale pain score exceeded the range denoting ‘analgesic success’, and showed considerable exacerbation in the evening. Patients' pain decreased to a mean score of 15.4 one hour after administration of a nonsteroidal anti-inflammatory drug (metamizole).Conclusion:Analgesia is recommended for all patients in the first 3 days after septorhinoplasty, especially in the early evening.
Jugular foramen schwannoma presenting with glossopharyngeal neuralgia syncope syndrome
Authors: Saman Y , Whitehead D , Gleeson M 
Published: July 2010

AbstractIntroduction:Jugular foramen schwannomas are rare skull base tumours which typically have a variable clinical presentation. Glossopharyngeal syncope syndrome is an unusual clinical presentation; in the following case report, it was the sole presentation of an extracranial jugular foramen tumour.Methods:The presentation of a patient with glossopharyngeal neuralgia syncope syndrome is reviewed and the pathophysiology, clinical features and treatment discussed.Results:A 45-year-old woman presented with unilateral throat pain, bradycardia and hypotension leading to episodes of impaired consciousness when lying on her left side or turning her head to the left. Imaging detected a left-sided extracranial jugular foramen schwannoma. The tumour was excised, and the patient had no more syncopal attacks.Conclusion:Glossopharyngeal neuralgia syncope syndrome can be the sole presentation of a jugular foramen schwannoma. Although this syndrome may be treated with anti-dysrhythmic drugs, cardiac pacing or nerve section, in the presented patient excision of the jugular foramen schwannoma was successful in preventing further episodes of syncope.
Lemierre's and Lemierre's-like syndromes in association with infectious mononucleosis
Authors: Chacko E M , Krilov L R , Patten W , Lee P J 
Published: July 2010

AbstractObjective:This study aimed to review cases of Lemierre's and Lemierre's-like syndromes in paediatric patients, to examine a possible association with Epstein–Barr virus as a predisposing factor, and to assess the impact of this virus on the severity of illness.Methods:We performed a retrospective analysis of data from the in-patient database at Winthrop University Hospital, from January 2001 to October 2007. We reviewed clinical and laboratory findings as well as the outcome of infection in patients aged 21 years or less with a diagnosis of Lemierre's syndrome. An additional case of Lemierre's-like syndrome was also included. The illness severity and duration of in-patient management of those testing positive for heterophile antibody were then compared with the same parameters in patients who tested negative.Results:Of the five patients diagnosed with Lemierre's syndrome, two had concomitant acute infection with Epstein–Barr virus. Additionally, a 19-year-old adolescent was admitted during this period with acute infectious mononucleosis, Fusobacterium necrophorum sepsis, sinusitis, frontal lobe abscess and ophthalmic vein thrombosis. The clinical presentation of all patients included fever, sore throat, and ear or neck pain. The duration of symptoms ranged from two days to three weeks prior to admission. The patients with acute Epstein–Barr virus infection had been diagnosed with infectious mononucleosis prior to admission, and tested positive for heterophile antibody. These patients subsequently underwent more extensive in-patient treatment, including intensive care management and ventilator support. The patients who tested negative for heterophile antibody experienced a milder course of illness, with a shorter duration of in-patient management.Conclusion:Two patients diagnosed with Lemierre's syndrome, and a third with Fusobacterium necrophorum sepsis, had coexisting acute Epstein–Barr virus infection. Patients who tested positive for heterophile antibody experienced a more severe course of illness. These observations suggest a possible association between Epstein–Barr virus infection and the severity of concomitant Lemierre's syndrome.
Validating an ecological model with fisheries management applications: the relationship between loggerhead by-catch and distance to the coast
Authors: Báez José C. , Real Raimundo , Bellido Jesús , Macias David , de la Serna José M. , Camiñas Juan A. 
Published: July 2010

On the one hand, a recent study on sea turtle by-catch during surface longline fishing targeting swordfish in the western Mediterranean Sea showed that sea turtle by-catch is independent of fishing effort and other technological factors. When the distance to the coast increases, there is a higher probability of catching a loggerhead turtle. The authors proposed to avoid fisheries further than 35 nautical miles (approximately 65 km) from the coast. However, the proposed 35 nautical miles limit could be useful where the continental shelf is narrow, as in the Balearic Sea, and useless where it widens. On the other hand, ecological model validation is considered essential for management application. The objective of the present paper is to validate the new fisheries loggerhead by-catch model in different areas outside the Balearic Sea with wider continental shelves, aimed at maintaining sustainable fishing activity compatible with the conservation of the loggerhead populations. Our present results validate the previous model, and stress the importance of the eco-geographical variable distance to the coast in understanding the loggerhead by-catch (or incidental capture) per unit effort for the longline fisheries targeting swordfish.
The population of Errina aspera (Hydrozoa: Stylasteridae) of the Messina Strait (Mediterranean Sea)
Authors: Salvati Eva , Angiolillo Michela , Bo Marzia , Bavestrello Giorgio , Giusti Michela , Cardinali Andrea , Puce Stefania , Spaggiari Costanza , Greco Silvestro , Canese Simonepietro 
Published: July 2010

Errina aspera is the only species belonging to the family Stylasteridae known from the Mediterranean Sea. The distribution of this species includes the Messina Strait, the Gibraltar Strait and the Atlantic coast of Morocco. In spite of the taxonomic and biogeographical importance of this species, no studies were conducted on its population structure in the Messina Strait. Here we report a study carried out with the aid of a ROV on a horizontal transect 350 m long at a depth comprised between 83 and 105 m where an extremely dense population of this stylasterid (101.4 ± 13.3 m−2) was recorded. The main components of the benthic community other than E. aspera are the coralline alga Lithothamnion philippii and the white zoanthid Epizoanthus sp. The colonies of E. aspera have a height ranging between 1.2 and 18.8 cm (4.1 ± 0.1 cm on average); they generally show a bi-dimensional, fan shaped morphology, but three-dimensional, brush-like specimens are also observed. The size–frequency distribution of the colony height is unimodal with a mode in the classes of 3–5 cm and a long tail of rare large colonies suggesting that the current may act as a limiting factor for the colony growth. The association with the gastropod ovulid Pedicularia sicula is confirmed.
Identification and characterization of a surface-associated, subtilisin-like serine protease inTrichomonas vaginalis
Authors: HERNÁNDEZ-ROMANO PABLO , HERNÁNDEZ ROBERTO , ARROYO ROSSANA , ALDERETE JOHN F. , LÓPEZ-VILLASEÑOR IMELDA 
Published: July 2010

SUMMARYTrichomonas vaginalisis a protozoan parasite causing trichomonosis, a sexually transmitted infection in humans. This parasite has numerous proteases, most of which are cysteine proteases that appear to be involved in adherence and cytotoxicity of host cells. In this report we identify and characterize a putative subtilisin-like serine protease (SUB1). Thesub1gene encodes a 101-kDa protein.In silicoanalyses predict signal and pro-peptides at the N-terminus, and a transmembrane helix at the carboxy-terminal region. Thesub1gene was found as single copy by Southern analysis, albeit additional serine protease related genes are annotated in theT. vaginalisgenome. The expression ofsub1could only be detected by RT-PCR and Ribonuclease Protection Assays, suggesting a low abundant mRNA. Thesub1gene transcription start site was correctly assigned by RPA. The transcript abundance was found to be modulated by the availability of iron in the growth medium. Antibodies raised to a specific SUB1 peptide recognized a single protein band (~82 kDa) in Western blots, possibly representing the mature form of the protein. Immunofluorescence showed SUB1 on the trichomonad surface, and in dispersed vesicles throughout the cytoplasm. A bioinformatic analysis of genes annotated as serine proteases in theT. vaginalisgenome is also presented. To our knowledge this is the first putative serine protease experimentally described forT. vaginalis.
Discrimination of fish populations using parasites: Random Forests on a ‘predictable’ host-parasite system
Authors: PÉREZ-DEL-OLMO A. , MONTERO F. E. , FERNÁNDEZ M. , BARRETT J. , RAGA J. A. , KOSTADINOVA A. 
Published: July 2010

SUMMARYWe address the effect of spatial scale and temporal variation on model generality when forming predictive models for fish assignment using a new data mining approach, Random Forests (RF), to variable biological markers (parasite community data). Models were implemented for a fish host-parasite system sampled along the Mediterranean and Atlantic coasts of Spain and were validated using independent datasets. We considered 2 basic classification problems in evaluating the importance of variations in parasite infracommunities for assignment of individual fish to their populations of origin: multiclass (2–5 population models, using 2 seasonal replicates from each of the populations) and 2-class task (using 4 seasonal replicates from 1 Atlantic and 1 Mediterranean population each). The main results are that (i) RF are well suited for multiclass population assignment using parasite communities in non-migratory fish; (ii) RF provide an efficient means for model cross-validation on the baseline data and this allows sample size limitations in parasite tag studies to be tackled effectively; (iii) the performance of RF is dependent on the complexity and spatial extent/configuration of the problem; and (iv) the development of predictive models is strongly influenced by seasonal change and this stresses the importance of both temporal replication and model validation in parasite tagging studies.
‘Sporting Moscow’: stadia buildings and the challenging of public space in the post-war Soviet Union
Authors: KÖHRING ALEXANDRA 
Published: July 2010

ABSTRACT:The Moscow Luzhniki stadia (1954–56) were constructed at the beginning of Khrushchev's reforms as a representative object to launch a rejuvenated and modernized socialism. The article seeks to situate the stadia complex in the crucial processes of urban transformation that occurred in the post-war Soviet Union; in questioning the Stalin monumental style, the planning of Luzhniki opened a more relational understanding of public space to Soviet people.
Choice cuts: parsing policymakers’ pursuit of patient empowerment from an individual perspective
Authors: Schlesinger Mark 
Published: July 2010

AbstractIn this commentary I explore several ways in which the psychology of individual decision-making shapes consumers’ choices in medical settings and the potential for choice-based policies to improve the performance of the health care system. This analysis draws some crucial distinctions among the various pathways though which policymakers expect choice to improve outcomes and the various forms of support that might enhance patients’ engagement with choice. I also consider how choice-promoting policies interact with other strategies for patient empowerment and depend crucially on the ways in which individual patients develop the capacity to make sense of their experiences with medical care. Drawing largely on data and studies from medical consumerism in the US, I identify a number of choice ‘pathologies’ that might compromise the influence or beneficial effects of choice-promoting initiatives. Though these limitations are unlikely to turn public officials away from their consumerist policy aspirations, identifying the realistic limitations of such initiatives makes clear the need to complement them with other strategies for enhancing patients’ well being and encouraging a more responsive health care system.
Asymptotics of greedy energy points
Authors: García A. López , Saff E. 
Published: July 2010

For a symmetric kernel

k
:
X
×
X
→

R

∪
{
+
∞
}

k:X\times X \rightarrow \mathbb {R}\cup \{+\infty \}

on a locally compact metric space

X
X

, we investigate the asymptotic behavior of greedy

k
k

-energy points

{

a

i

}

1

∞

\{a_{i}\}_{1}^{\infty }

for a compact subset

A
⊂
X

A\subset X

that are defined inductively by selecting

a

1

∈
A

a_{1}\in A

arbitrarily and

a

n
+
1

a_{n+1}

so that

∑

i
=
1

n

k
(

a

n
+
1

,

a

i

)
=

inf

x
∈
A

∑

i
=
1

n

k
(
x
,

a

i

)

\sum _{i=1}^{n}k(a_{n+1},a_{i})=\inf _{x\in A}\sum _{i=1}^{n}k(x,a_{i})

. We give sufficient conditions under which these points (also known as Leja points) are asymptotically energy minimizing (i.e. have energy

∑

i
≠
j

N

k
(

a

i

,

a

j

)

\sum _{i\neq j}^{N}k(a_{i},a_{j})

as

N
→
∞

N\rightarrow \infty

that is asymptotically the same as

E

(
A
,
N
)
:=
min
{

∑

i
≠
j

k
(

x

i

,

x

j

)
:

x

1

,
…
,

x

N

∈
A
}

\mathcal {E}(A,N):=\min \{\sum _{i\neq j}k(x_{i},x_{j}):x_{1},\ldots ,x_{N}\in A\}

), and have asymptotic distribution equal to the equilibrium measure for

A
A

. For the case of Riesz kernels

k

s

(
x
,
y
)
:=

|

x
−
y

|

−
s

k_{s}(x,y):=|x-y|^{-s}

,

s
>
0

s>0

, we show that if

A
A

is a rectifiable Jordan arc or closed curve in

R

p

\mathbb {R}^{p}

and

s
>
1

s>1

, then greedy

k

s

k_{s}

-energy points are not asymptotically energy minimizing, in contrast to the case

s
>
1

s>1

. (In fact, we show that no sequence of points can be asymptotically energy minimizing for

s
>
1

s>1

.) Additional results are obtained for greedy

k

s

k_{s}

-energy points on a sphere, for greedy best-packing points (the case

s
=
∞

s=\infty

), and for weighted Riesz kernels. For greedy best-packing points we provide a simple counterexample to a conjecture attributed to L. Bos.
Characterization of a Novel Resistant‐Starch and Its Effects on Postprandial Plasma‐Glucose and Insulin Responses
Authors: Hasjim Jovin , Lee Sun‐Ok , Hendrich Suzanne , Setiawan Stephen , Ai Yongfeng , Jane Jay‐lin 
Published: July 2010

ABSTRACTObjectives of this study were to understand the physicochemical properties of a novel resistant starch (RS) made by complexing high‐amylose maize starch VII (HA7) with palmitic acid (PA), and its effects on reducing postprandial plasma‐glucose and insulin responses. The HA7 starch was heat‐treated and debranched using isoamylase (ISO) to enhance the starch‐lipid complex formation. The RS content of the HA7 starch debranched with ISO and complexed with PA (HA7+ISO+PA) was 52.7% determined using AOAC Method 991.43 for dietary fiber, which was greater than that of the HA7 control (35.4%). The increase in the RS content of the HA7+ISO+PA sample was attributed to the formation of retrograded debranched‐starch and starch‐lipid complex. The postprandial plasma‐glucose and insulin responses of 20 male human‐subjects after ingesting bread made from 60% (dry basis) HA7+ISO+PA were reduced to 55 and 43%, respectively, when compared with those after ingesting control white bread (as 100%) containing the same amount of total carbohydrates. The results suggested that the HA7+ISO+PA can be used for the interventions of insulin resistance and metabolic syndrome, including diabetes and obesity.
Obesity impairs general health‐related quality of life (HR‐QoL) in premenopausal women to a greater extent than polycystic ovary syndrome (PCOS)
Authors: Álvarez‐Blasco Francisco , Luque‐Ramírez Manuel , Escobar‐Morreale Héctor F. 
Published: July 2010

SummaryObjective  Obesity is frequently associated with the polycystic ovary syndrome (PCOS) and both conditions may impact on the health‐related quality of life (HR‐QoL) of affected patients. We aimed to estimate the relative impact of obesity and PCOS on the general HR‐QoL of premenopausal women.Design  Case–control study.Patients  Consecutive overweight and obese premenopausal women seeking advice for weight loss, of whom 32 were diagnosed with PCOS and 72 had no evidence of androgen excess and were considered controls.Measurements  Spanish versions of the Short Form 36 Health Survey (SF‐36) questionnaire and the Nottingham Health Profile (NHP) were self‐administered by the women.Results  Patients with PCOS and controls had similar body mass index, yet controls were older. General HR‐QoL mean scores were similar in both groups, yet patients with PCOS scored worse in the role‐emotional item of SF‐36, and controls scored worse in the pain item of NHP. Increasing grades of obesity, on the contrary, were associated with worse scores in the NHP, and SF‐36 items related to general and physical aspects of HR‐QoL. When compared with the standards established for the Spanish general population, both patients with PCOS and controls frequently presented with abnormal scores, yet only increasing grades of obesity were associated with more frequent abnormal scoring.Conclusions  Obesity impaired general HR‐QoL to a greater extent than PCOS in overweight and obese premenopausal women.