bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting image quality measure for automatic trajectory generation in robot-aided visual quality inspection
Authors: Jafari-Tabrizi Atae , Gruber Dieter P. , Gams Andrej 
Published: April 2024

AbstractCurrently, the standard method of programming industrial robots is to perform it manually, which is cumbersome and time-consuming. Thus, it can be a burden for the flexibility of inspection systems when a new component with a different design needs to be inspected. Therefore, developing a way to automate the task of generating a robotic trajectory offers a substantial improvement in the field of automated manufacturing and quality inspection. This paper proposes and evaluates a methodology for automatizing the process of scanning a 3D surface for the purpose of quality inspection using only visual feedback. The paper is divided into three sub-tasks in the same general setting: (1) autonomously finding the optimal distance of the camera on the robot’s end-effector from the surface, (2) autonomously generating a trajectory to scan an unknown surface, and (3) autonomous localization and scan of a surface with a known shape, but with an unknown position. The novelty of this work lies in the application that only uses visual feedback, through the image focus measure, for determination and optimization of the motion. This reduces the complexity and the cost of such a setup. The methods developed have been tested in simulation and in real-world experiments and it was possible to obtain a precision in the optimal pose of the robot under 1 mm in translational, and 0.1$$^\circ $$

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in angular directions. It took less than 50 iterations to generate a trajectory for scanning an unknown free-form surface. Finally, with less than 30 iterations during the experiments it was possible to localize the position of the surface. Overall, the results of the proposed methodologies show that they can bring substantial improvement to the task of automatic motion generation for visual quality inspection.
Biotransformation and toxicokinetics of 2-phenoxyethanol after oral exposure in humans: a volunteer study
Authors: Eckert Elisabeth , Jäger Thomas , Hiller Julia , Leibold Edgar , Bader Michael , Göen Thomas 
Published: April 2024

Abstract2-Phenoxyethanol (PhE) is an aromatic glycol ether and is used in a variety of functions and applications, e.g., as preservative in pharmaceuticals, cosmetic and personal care products, as biocide in disinfectants (e.g. human hygiene), or as a solvent in formulations (e.g. coatings, functional fluids). Despite its widespread use, little is yet known on its biotransformation and toxicokinetics in humans. Therefore, a pilot study was conducted with oral administration of PhE (5 mg/kg body weight) to five volunteers. Blood and urine samples were collected and analyzed for PhE and three of its presumed metabolites up to 48 h post-exposure. Additionally, one volunteer was dermally exposed to PhE and monitored until 72 h post-exposure. PhE was rapidly resorbed following both oral and dermal application with tmax-levels in blood of about 1 h and 3 h, respectively. Metabolism of PhE was observed to be rather extensive with phenoxyacetic acid (PhAA) and 4-hydroxyphenoxyacetic acid (4-OH-PhAA) as the main metabolites found in blood and urine following oral and dermal exposure. PhE was excreted rapidly and efficiently via urine mostly in metabolized form: following oral exposure, on average 77% and 12% of the applied dose was excreted within 48 h as PhAA and 4-OH-PhAA, respectively. A similar metabolism pattern was observed following the single dermal exposure experiment. The obtained data on biotransformation and toxicokinetics of PhE in humans provide valuable information on this important chemical and will be highly useful for pharmacokinetic modelling and evaluation of human PhE exposure.
Clonal expansion of shared T cell receptors reveals the existence of immune commonality among different lesions of synchronous multiple primary lung cancer
Authors: Wang Yadong , Huang Zhicheng , Li Bowen , Xue Jianchao , Guo Chao , Bing Zhongxing , Zheng Zhibo , Song Yang , Xu Yuan , Huang Guanghua , Li Haochen , Yu Xiaoqing , Xia Yankai , Li Ruirui , Si Xiaoyan , Zhang Li , Li Ji , Song Lan , Xiong Yuanyuan , Gu Dejian , Song Mengmeng , Zhou Zhipeng , Chen Rongrong , Feng Zhe , Bie Zhixin , Li Xiaoguang , Yang Huaxia , Li Shanqing , Liang Naixin 
Published: April 2024

AbstractThe increase in the detection rate of synchronous multiple primary lung cancer (MPLC) has posed remarkable clinical challenges due to the limited understanding of its pathogenesis and molecular features. Here, comprehensive comparisons of genomic and immunologic features between MPLC and solitary lung cancer nodule (SN), as well as different lesions of the same patient, were performed. Compared with SN, MPLC displayed a lower rate of EGFR mutation but higher rates of BRAF, MAP2K1, and MTOR mutation, which function exactly in the upstream and downstream of the same signaling pathway. Considerable heterogeneity in T cell receptor (TCR) repertoire exists among not only different patients but also among different lesions of the same patient. Invasive lesions of MPLC exhibited significantly higher TCR diversity and lower TCR expansion than those of SN. Intriguingly, different lesions of the same patient always shared a certain proportion of TCR clonotypes. Significant clonal expansion could be observed in shared TCR clonotypes, particularly in those existing in all lesions of the same patient. In conclusion, this study provided evidences of the distinctive mutational landscape, activation of oncogenic signaling pathways, and TCR repertoire in MPLC as compared with SN. The significant clonal expansion of shared TCR clonotypes demonstrated the existence of immune commonality among different lesions of the same patient and shed new light on the individually tailored precision therapy for MPLC.
Early expansion of mixed oak stands at 16,800–16,600 cal bp at a northern Italian glacial refugium in the Euganean Hills
Authors: Boltshauser-Kaltenrieder Petra , Tinner Willy 
Published: April 2024

AbstractContinuous sedimentary lake records covering the Last Glacial Maximum (LGM) are very rare in Europe. Here, we conducted additional palynological analyses to connect two separate radiocarbon-dated pollen sequences of Lago della Costa (AP2 and AP1) to one complete vegetation history record of the Euganean Hills (“Colli Euganei”, northern Italy) covering the past ca. 32,000 years. Previous studies on autochthonous organic lake sediments revealed that during the Last Glacial Maximum (LGM) Lago della Costa likely acted as a refugium of temperate woody taxa. Based on the new data we present the first continuous record of the vegetation history of the Euganean Hills during the past 32,000 years. Specifically, we investigate the early establishment and mass expansion of deciduous Quercus at the refugial site at ca. 16,800–16,600 cal bp. In the oak forests other temperate taxa (e.g. Corylus avellana, Abies alba, Ulmus, Fraxinus excelsior, Vitis, Hedera, Tilia, Acer, Fagus sylvatica) also established at around this time, i.e. 2,000 years prior to the onset of the Bølling/Allerød interstadial (about 14,700–12,800 cal bp). The comparison of our data with other well-dated records from the river Po catchment and refugial sites elsewhere in Italy and southern Europe suggests expansions of boreal and nemoral forests over wide areas prior to the Bølling/Allerød interstadial, i.e. 2,000 years before comparable large-scale afforestation north of the Alps or ca. 45°N. Pollen-inferred expansions of temperate tree communities (e.g. oak forests) correspond to a climatic warming as reconstructed from quantitative, pollen-independent evidence (e.g. chironomids) from the Apennines, Northern Italy, Southern Switzerland and the Swiss Plateau, suggesting that pre-Bølling afforestation processes south of the Alps were promoted by increasing (summer) temperatures during the Oldest Dryas.
Harnessing deep learning for faster water quality assessment: identifying bacterial contaminants in real time
Authors: Khokhar Fahad Ahmed , Shah Jamal Hussain , Saleem Rabia , Masood Anum 
Published: April 2024

Abstract
Water is essential for human survival. Humans can live without food for a few days but without water, a person can barely survive for 3–5 days. Various parts of the world, particularly under-developed countries, have regions where clean water is scarce, and humans living in such conditions have no access to clean water. Our solution provides information on whether water is contaminated or not. Moreover, it overcomes the delay time in getting the result of water contamination using traditional methods of up to 5–6 hrs. Our proposed method detects the colonies of the bacteria that are taken from the water sample (after gram staining) and then classifies the type of bacteria to whom it belongs and how much quantity of each bacterium causes infection to the human body. Bacteria detection is performed by a novel deep learning-based model with user-specified parameters. To improve our ability to detect dangerous bacteria including E. coli, yeast, and particles, we perform tests using datasets from a variety of researchers. On the test benchmark, the fine-tuned proposed model achieves 84.56% accuracy and provides the level of contamination in water.
Spanish translation and validation of the Music-Related Quality of Life Questionnaire (MuRQoL) in postlingually deaf cochlear implant users
Authors: Zuazua-Gonzalez Alejandro , Calvino Miryam , Postigo Álvaro , Domingo Carlos , Gavilán Javier , Lassaletta Luis 
Published: April 2024

Abstract
Purpose
The aim of this study was to translate and validate the “Music-Related Quality of Life Questionnaire” into Spanish (sMuRQoL) and assess its convergent validity and discriminative capacity by comparing its scores with the outcomes of the musical perception test Meludia.

Methods
The sMuRQoL was completed by 129 patients: 55 cochlear implant (CI) users and 74 normal hearing (NH) individuals. Conducted in this study were an exploratory factor analysis, an evaluation of internal consistency, an assessment of score stability through test–retest reliability, a comparison of sMuRQoL scores between CI users and NH individuals and an examination of potential evidence of convergent validity and discriminative capacity of sMuRQoL in relation to other tools. This involved the comparison of the questionnaire scores with the Meludia outcomes.

Results
The sMuRQoL demonstrated a two-dimensional structure. All the dimensions displayed high internal consistency (α = 0.879–0.945) and score stability (ICC = 0.890–0.942). There were significant differences in the Frequency test between NH and CI users (d = 1.19–1.45). There’s evidence of convergent validity between the scores of the Frequency test and the results of Meludia (r = 0.242–0.645). Additionally, the Frequency test demonstrate a good discriminative capacity to identify patients with poorer musical perception.

Conclusions
The sMuRQoL is a reliable questionnaire, with adequate evidence of validity based on internal structure. This study provides an accessible, cost-effective, and quick-to-administer instrument in Spanish, optimizing available healthcare resources and bringing us closer to the patient needs.
Technical note: Temperature estimation accuracy based on colourimetry of embalmed human and fresh non-human burned bone
Authors: Krap Tristan , Leenstra Afke , Oostra Roelof-Jan , Duijst Wilma 
Published: April 2024

AbstractEstimation of the exposure temperature of skeletal remains can be done by means of colourimetry and a previously published decision model for the colourimetric data, resulting in clusters that represent a range of exposure temperature. The method was based on thermally altered freshly burned human skeletal remains. However, in practice the origin or pre-burning condition of (possibly fragmentary) burned remains can be unknown. Further, in order to use the colourimetric analysis, and accompanying decision model, it is important to have a reference or test set. Fresh human material is not available for this purpose in all countries. Hence, the classification accuracy of the decision model was tested for, in some countries more readily available substitutes for fresh bone; embalmed human bone and non-human bone. The model yielded high accuracies for these sample materials, making it possible to create a reference or test set from fresh non-human and embalmed human bone as substitute for human, and also to use the decision model for these deviating samples in practice.
Efficacy and safety of chemoimmunotherapy in advanced non-small cell lung cancer patients with antibiotics-induced dysbiosis: a propensity-matched real-world analysis
Authors: Tamura Kentaro , Okuma Yusuke , Nomura Shogo , Fukuda Akito , Masuda Ken , Matsumoto Yuji , Shinno Yuki , Yoshida Tatsuya , Goto Yasushi , Horinouchi Hidehito , Yamamoto Noboru , Ohe Yuichiro 
Published: April 2024

Abstract
Purpose
The gut microbiota is hypothesized as a prognostic biomarker for cancer immunotherapy. Antibiotic-induced dysbiosis negatively affects the clinical outcomes of immunotherapy. However, the effect of dysbiosis on the efficacy and safety of Chemoimmunotherapy (chemo-IOs), the frontline standard of care, in advanced non-small cell lung cancer (NSCLC) remains unknown. We aimed to compare the efficacy and safety of chemo-IOs in patients exposed to antibiotics before treatment with those of patients who were not exposed.

Methods
We retrospectively reviewed patients with advanced NSCLC treated with first-line chemo-IOs between 2018 and 2020 at the National Cancer Center Hospital. The patients were divided into two groups: those exposed to antibiotics within 30 days before induction therapy (ABx group) and those did not antibiotics (Non-ABx group). Propensity score matching was used to control for potential confounding factors. Clinical outcomes including progression-free survival (PFS), overall survival (OS), and immune-related adverse events (irAEs) were compared.

Results
Of 201 eligible patients, 21 were in the ABx group, and 42 were in the non-ABx group after propensity score matching. No differences in PFS or OS emerged between the two groups (ABx group vs. Non-ABx group) (PFS:7.0 months vs. 6.4 months, hazard ratio [HR] 0.89; 95% confidence interval [CI], 0.49–1.63, OS:20.4 months vs. 20.1 months, HR 0.87; 95% CI 0.44–1.71). The frequency of irAEs before propensity score matching was similar across any-grade irAEs (39.4% vs. 42.9%) or grade 3 or higher irAEs (9.1% vs. 11.3%).

Conclusion
Antibiotic-induced dysbiosis may not affect the efficacy of chemo-IOs in patients with advanced NSCLC.
Merkel cell carcinoma overlapping Bowen’s disease: two cases report and literature review
Authors: Chen Xueqin , Song Xiao , Huang Hui , Zhang Lian , Song Zhiqiang , Yang Xichuan , Lei Shanchuan , Zhai Zhifang 
Published: April 2024

AbstractPurposeMerkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin, which mainly occurs in the sun exposed sites of white patients over 65 years, with a higher recurrence and metastasis rate. Clinically, MCC overlapping Bowen’s disease (BD) is a very rare subtype of MCC. Few cases in the literature have been described and the management is not well defined. We summarize and update the epidemiology, clinical and histopathological features, metastasis characteristics, local recurrence rate and management of it by presenting two cases of MCC overlapping BD and reviewing the literature over the last 11 years.DesignWe consulted databases from PubMed, ResearchGate and Google Scholar by MeSh “Merkel cell carcinoma” and “Bowen’s disease”, “Bowen disease” or “squamous cell carcinoma in situ”, from January 2013 to December 2023 and reviewed the literatures. We reported two additional cases.ResultsTotal 13 cases of MCC overlapping BD were retrospectively analyzed, in whom mainly in elderly women over 70 years, the skin lesions were primarily located on the faces, followed by the extremities and trunk. Most of them were asymptomatic, firm, dark red nodules arising on rapidly growing red or dark brown patches, or presenting as isolated nodules. Dermoscopy evaluation was rarely performed in the pre-operative diagnostic setting. All cases were confirmed by histopathology and immunohistochemistry. The most definitive treatment was extended local excision, but local recurrences were common. Of the 13 cases, 4 cases experienced local or distant metastasis. One suffered from an in-transit recurrence of MCC on the ipsilateral leg after local excision and lymph node dissection, whose metastasis completely subsided after avelumab treatment and without recurrence or metastasis during 6 months of follow-up.ConclusionsMCC overlapping BD is a very rare skin tumor mainly predisposed on the faces, with high misdiagnosis rate and recurrence rate. Advanced disease at diagnosis is a poor prognostic factor, suggesting that earlier detection may improve outcome. The acronym, AEIOUN, has been proposed to aid in clinical identification. Our reports and the literature review can provide a better awareness and management of it.
The role of victimisation and sleep quality in self-harm and depression among sexual minority adolescents. A prospective cohort study
Authors: Tepman Alexandra , Wong Mark Lawrence 
Published: April 2024

AbstractSexual minority adolescents (SMA) have a disproportionately high prevalence of victimisation, self-harm, and depressed mood, relative to the general population. Yet, the contributing and mechanistic factors are unclear. We aim to explore the directional relationship between victimisation and self-harm and depressed mood, with poor sleep quality as a possible mediator. A secondary data analysis was conducted using a nationally representative birth cohort in the United Kingdom, where participants self-identified as sexual minority (N = 1922, aged 11–13, 67.1% female) and their parents completed questionnaires and interviews when the participants were aged 11, 14 and 17. Logistic and linear regression were used to test whether victimisation prospectively predicted self-harm and depressed mood with mediation analyses conducted to assess if sleep onset latency and nocturnal awakening mediated their relationships. After adjusting for demographic factors and baseline self-harm and depressed mood, victimisation at age 11 significantly predicted self-harm (OR = 1.40, p < .01) and depressed mood (B = 0.024, SE = 0.01, p < .05) at age 17. In the mediation analyses, frequent nocturnal awakening at age 14, but not sleep onset latency, significantly mediated the effect of victimisation at age 11 on self-harm (indirect effect B = 0.008, SE = 0.004, 95%CI = 0.001-0.017) and depressed mood (indirect effect B = 0.005, SE = 0.002 95%CI = 0.001-0.010) at age 17. Our findings supported that victimisation contributed to negative mental health among SMA. Poor sleep quality could be an indicator of maladjustment with victimisation, which further increased vulnerability to negative mental health. Victimisation and sleep quality could be important assessment targets in mental health campaign among sexual minority adolescents.
On the influence of local deformation on structural dynamic models of bolted lap joints
Authors: Wischmann Stefan , Jacobs Georg , Höpfner Gregor 
Published: April 2024

AbstractThe acoustic and structural dynamic behavior of technical products—often referred to as Noise, Vibration, and Harshness (NVH)—is an important criterion in customers’ purchasing decisions. Therefore, NVH optimization is a crucial goal of the development process. NVH is influenced by dynamic excitations, caused by time-varying forces e.g. in gears or electric machines, as well as the transfer path of sound from the location of excitation to a receiver such as a driver’s ear and the sound perception. The behavior of the transfer path is determined by amplification or isolation of structure-borne and airborne sound between the location of the excitation and the location of the receiver. As a result, eigenfrequencies and damping in the transfer path form crucial structural dynamic properties.Within jointed structures, friction between the surfaces of lap joints are the most dominant influencing factor on the transfer path’s damping. In order to increase the efficiency of NVH optimization in the development process, methods of virtual product development have become an established tool. Especially finite element method (FEM) and elastic multi-body simulation (eMBS) have allowed to numerically evaluate the structural dynamic behavior of technical products before manufacturing physical prototypes. While numerous methods for modeling jointed structures exist in FEM and eMBS environments, the choice of suitable eMBS models of joints remains challenging today. This is because the frictional behavior between the jointed partners in higher frequencies is largely influenced by the deformation of the joint surface. However, the deformation of the jointed parts is simplified in eMBS models compared to quasi-continuous FEM models. Accordingly, the choice of a suitable spatial discretization of eMBS joint models is a key factor in the model quality of eMBS models. Thus, this work proposes a modeling guideline for eMBS models of jointed structures based on the deformation of the structure using the criterion of rigidness. The method is demonstrated on an eMBS model of the academic Brake Reuß beam, which consists of two beam elements jointed with three screws in an overlap lap joint. Good agreement between eMBS simulation and measurement with an error of 1 dB is achieved using the proposed modeling method.
Evaluation of visual, auditory, and olfactory stimulus-based attractors for intermittent reorientation in virtual reality locomotion
Authors: Lee Jieun , Hwang Seokhyun , Kim Kyunghwan , Kim SeungJun 
Published: April 2024

AbstractIn virtual reality, redirected walking (RDW) enables users to stay within the tracking area while feeling that they are traveling in a virtual space that is larger than the physical space. RDW uses a visual attractor to the user’s sight and scene manipulation for intermittent reorientation. However, repeated usage can hinder the virtual world immersion and weaken the reorientation performance. In this study, we propose using sounds and smells as alternative stimuli to draw the user’s attention implicitly and sustain the attractor’s performance for intermittent reorientation. To achieve this, we integrated visual, auditory, and olfactory attractors into an all-in-one stimulation system. Experiments revealed that the auditory attractor caused the fastest reorientation, the olfactory attractor induced the widest angular difference, and the attractor with the combined auditory and olfactory stimuli induced the largest angular speed, keeping users from noticing the manipulation. The findings demonstrate the potential of nonvisual attractors to reorient users in situations requiring intermittent reorientation.