bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disinfection of sink drains to reduce a source of three opportunistic pathogens, during Serratia marcescens clusters in a neonatal intensive care unit
Authors: Bourdin Thibault , Benoit Marie-Ève , Prévost Michèle , Charron Dominique , Quach Caroline , Déziel Eric , Constant Philippe , Bédard Emilie 
Published: June 2024

Objective
Evaluate the effects of five disinfection methods on bacterial concentrations in hospital sink drains, focusing on three opportunistic pathogens (OPs): Serratia marcescens, Pseudomonas aeruginosa and Stenotrophomonas maltophilia.

Design
Over two years, three sampling campaigns were conducted in a neonatal intensive care unit (NICU). Samples from 19 sink drains were taken at three time points: before, during, and after disinfection. Bacterial concentration was measured using culture-based and flow cytometry methods. High-throughput short sequence typing was performed to identify the three OPs and assess S. marcescens persistence after disinfection at the genotypic level.

Setting
This study was conducted in a pediatric hospitals NICU in Montréal, Canada, which is divided in an intensive and intermediate care side, with individual rooms equipped with a sink.

Interventions
Five treatments were compared: self-disinfecting drains, chlorine disinfection, boiling water disinfection, hot tap water flushing, and steam disinfection.

Results
This study highlights significant differences in the effectiveness of disinfection methods. Chlorine treatment proved ineffective in reducing bacterial concentration, including the three OPs. In contrast, all other drain interventions resulted in an immediate reduction in culturable bacteria (4–8 log) and intact cells (2–3 log). Thermal methods, particularly boiling water and steam treatments, exhibited superior effectiveness in reducing bacterial loads, including OPs. However, in drains with well-established bacterial biofilms, clonal strains of S. marcescens recolonized the drains after heat treatments.

Conclusions
Our study supports thermal disinfection (>80°C) for pathogen reduction in drains but highlights the need for additional trials and the implementation of specific measures to limit biofilm formation.
A Data-Driven Method for Parametric PDE Eigenvalue Problems Using Gaussian Process with Different Covariance Functions
Authors: Alghamdi Moataz , Bertrand Fleurianne , Boffi Daniele , Halim Abdul 
Published: June 2024

Abstract
We use a Gaussian Process Regression (GPR) strategy to analyze different types of curves that are commonly encountered in parametric eigenvalue problems.
We employ an offline-online decomposition method.
In the offline phase, we generate the basis of the reduced space by applying the proper orthogonal decomposition (POD) method on a collection of pre-computed, full-order snapshots at a chosen set of parameters.
Then we generate our GPR model using four different Matérn covariance functions.
In the online phase, we use this model to predict both eigenvalues and eigenvectors at new parameters.
We then illustrate how the choice of each covariance function influences the performance of GPR.
Furthermore, we discuss the connection between Gaussian Process Regression and spline methods and compare the performance of the GPR method against linear and cubic spline methods.
We show that GPR outperforms other methods for functions with a certain regularity.
Wie situiert sich Theorie?
Authors: Eusterschulte Anne 
Published: June 2024

Abstract
The essay outlines modelling theory in terms of an active form of thinking. In contrast to concepts of theory whose validity can be described by a scientific explanatory approach with a systematic character and the claim to universalization regarding a specific field of research, the question here is about varieties of theory building. The focus is on theoretical activity, not on theory as a result. Based on ancient implications of the term θεωρία (theoria), models of a theoretical activity, attitude or stance are brought into focus, whereby ways of distancing are constitutive in each case. What does theorizing mean from the perspective of a spectator and to what extent is purposelessness to be thought of as a critical potential? Does the theoretical performance of thought include a sense of possibility and to what extent is this articulated in the aesthetic forms of language? Do theoretical realizations in the literary medium move on a threshold between historical determinisms and the freedom of a conceivable future? To what extent do theoretical views have a synaesthetic dimension, and can we imagine poetic language as a medium of theoretical reflection? Is the nuanced linguistic nature of theoretical articulation modes the very condition of critical intervention? All these modellings of aesthetic distancing ask about the forms in which theory can be expressed, including ways of writing theoretical activity.
Application of discrete symmetry to natural convection in vertical porous microchannels
Authors: Avramenko Andriy A. , Shevchuk Igor V. , Kovetskaya Margarita M. , Kovetska Yulia Y. , Kobzar Andrii S. 
Published: June 2024

Abstract
This work focuses on the study of natural convection in a flat porous microchannel with asymmetric heating. The novelty of the work lies in the fact that for the first time the method of discrete symmetries was used to analyze the complete system of Navier–Stokes and energy equations in a two-dimensional approximation. Analytical solutions for velocity and temperature profiles have been derived based on symmetry analysis, taking into account boundary conditions such as slip and temperature jump at the channel walls. The effect of Grashof, Knudsen, Darcy, and Prandtl numbers on the flow characteristics in the microchannel and heat transfer coefficients was elucidated. At high Grashof numbers, an ascending flow near the hot wall and a descending flow near the cold wall arise. Increasing the Knudsen number leads to an increase in the velocity, temperature jump at the walls and a decrease in heat transfer coefficients. As the Darcy number increases, velocities amplify in both ascending and descending flows. The temperature jump at the hot wall grows up, while it remains unchanged at the cold wall. In the same time, the heat transfer coefficient at the hot wall decreases.
miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
Authors: Jing Yanyan , Qi Lei , Zhang Xueli , Zheng Lu , Yang Peijin , Yin Jie , Shi Yugen , Yan Suhua 
Published: June 2024

Abstract

Objective
Sympathetic hyperinnervation following myocardial infarction (MI) is one of the primary causes of ventricular arrhythmias (VAs) after MI. Nerve growth factor (NGF) is a key molecule that induces sympathetic nerve remodeling. Previous studies have confirmed that microRNA (miR)-let-7a interacts with NGF. However, whether miR-let-7a is involved in sympathetic remodeling after MI remains unknown. We aimed to investigate whether miR-let-7a was associated with the occurrence of VA after MI.

Methods and results
A rat model of myocardial infarction was established using left coronary artery ligation. miR-let-7a expression levels were analyzed by reverse transcription-quantitative PCR. Western blotting was also used to examine NGF expression levels in vivo and in M1 macrophages in vitro. The relationship between miR-let-7a and NGF levels was investigated using a luciferase reporter assay. The results revealed that the expression of miR-let-7a decreased significantly after MI, while NGF expression was significantly upregulated. In addition, overexpression of miR-let-7a effectively inhibited NGF expression in rats, which was also verified in M1 macrophages. Tyrosine hydroxylase and growth-associated protein 43 immunofluorescence results revealed that the administration of a miR-let-7a overexpression lentivirus to rats inhibited sympathetic remodeling after MI. Programmed electrical stimulation, renal sympathetic nerve activity recording, and heart rate variability measurements showed that miR-let-7a overexpression decreased sympathetic activity.

Conclusions
These findings provide novel insights into the molecular mechanisms by which miR-let-7a and NGF contribute to the progression of sympathetic nerve remodeling after MI. Therefore, miR-let-7a may be a promising therapeutic target to reduce the incidence of arrhythmia following MI.
Joint effects of PPARG-C161T (rs3856806) polymorphism and cardiovascular risk factors on restenosis risk after coronary stent implantation
Authors: Javadova Zahra , Yanar Fatih , Aslan Ezgi Irmak , Ozkara Gulcin , Malikova Fidan , Kilicarslan Onur , Ser Ozgur Selim , Yildiz Ahmet , Kucukhuseyin Ozlem , Ozturk Oguz , Yilmaz Aydogan Hulya 
Published: June 2024

Abstract

Objectives
The peroxisome proliferator-activated receptor gamma (PPARG) C161T polymorphism (rs3856806) may be a risk factor for in-stent restenosis (ISR) due to its known associations with type 2 diabetes (T2DM), obesity, and coronary artery disease (CAD). This study aims to investigate the relationship between PPARG-C161T polymorphism and the risk of ISR, considering clinical features.

Methods
According to the results of coronary angiography, the patients who had undergone drug-eluting stent implantation were categorized into two groups: ISR (n=116) and non-ISR (n=265). The control group consisted of 140 healthy subjects with asymptomatic for CAD or any systemic disease. PPARG-C161T genotypes were determined using the real-time polymerase chain reaction melting curve analysis.

Results
T2DM, hypertension, and hyperlipidemia were observed as the main clinical features causing non-ISR and ISR. The 161-CC genotype was associated with an increased risk of ISR compared to both controls (p=0.014) and non-ISR patients (p=0.008). This difference remained statistically significant after multivariate analysis for non-ISR patients (p=0.003) but not for the ISR group. The prevalence of hypertension and hyperlipidemia was higher in ISR patients with T2DM than in non-ISR patients with T2DM (p=0.002 and p=0.009, respectively). Multivariate logistic regression analysis in subgroups based on the presence of T2DM showed that hypertension (p<0.001) was associated with ISR in patients with T2DM.

Conclusions
This study points out the association between the PPARG 161-CC genotype and the risk of ISR, which also means that the PPARG 161-T allele is protective against ISR. However, this effect could be divergent in the presence of the metabolic components of the restenosis phenotype, especially T2DM.
Researching Together: Disrupting Colonial Thinking in Higher Education and Beyond
Authors: Tangney Sue , Mooney Julie A. , López-Vélez Ana Luisa 
Published: June 2024

Las universidades, aunque se consideran centros de creación de conocimiento, también son producto del colonialismo. Este artículo se centra en un estudio autoetnográfico llevado a cabo por tres profesoras universitarias blancas que utilizamos pautas reflexivas para problematizar nuestra posición. Nuestro objetivo es comprendernos mejor a nosotras mismas y nuestras identidades, los beneficios que hemos obtenido del colonialismo y los enfoques apropiados que podemos adoptar para facilitar la descolonización de los planes de estudio. Consideramos que este autointerrogatorio y esta búsqueda colaborativa de significados, aunque a veces doloroso, constituyen una oportunidad enriquecedora y transformadora para el desarrollo personal y profesional, y un punto de partida para escuchar a los pueblos indígenas, trabajar con ellos y permitirles emprender una labor descolonizadora. Seguidamente, utilizamos esta experiencia para sugerir formas en las que otros y otras profesoras pueden participar en procesos similares de autorreflexión crítica y autodesarrollo, con el fin de desbaratar el pensamiento colonial en la educación superior y más allá.
Edukacinio 3D virtualiosios realybės vaizdo metodo įtaka ruošiant žarnyną kolonoskopijai: pirmieji rezultatai
Authors: Kildušis Edvinas , Brimas Gintautas 
Published: June 2024

Objective. Adequate bowel preparation is essential for diagnostic, screening, surveillance, and therapeutic colonoscopy. 3D virtual reality (3D-VR) has the characteristics of depth, interactivity and visuality and is widely used in medicine, so it can be used for patient education and training. The aim of our study is to determine the impact of using 3D virtual reality video for patients education on bowel preparation before colonoscopy. Materials and methods. A prospective, blind, randomized clinical trial was launched at the Republican Vilnius University Hospital (RVUL) on 07.03.2021, which included 50 outpatients who had indications for colonoscopy until 28.02.2022. Patients were randomly assigned to control and experimental groups. The first group was given the bowel preparation information in the standard form used by RVUL – in writing, and the second – in a 3D virtual reality video. The content of the information provided to both groups was the same. The quality of bowel preparation was assessed based on the Boston and Ottawa bowel preparation scales. Results. Of the 50 outpatients who participated in the study, 26 were assigned to the control group, 24 to the study group. The patients of both groups were identical in terms of sex, age, body mass index, comorbidities. The mean (SD) BBPS score was statistically significantly lower in the control group compared to the 3D-VR video group (5.96(±1) vs. 7.58(±1.47); p < 0.001). The mean (SD) scores of OBPS were higher in the control group (6.58(±2.44) than in the study group 1.83(±2.32); p < 0.001). The rate of adequate bowel preparation in the 3D-VR video group was higher than in the control group (18(69.23%) vs. 23(95.83%); the difference was statistically significant (p = 0.024)). The rate of terminal ileum intubation in the control group was 50% compared to 83.33% in the 3D-VR video group (p = 0.02).The mean (SD) colonoscopy time was statistically significantly shorter in the 3D-VR video group 23.04(±3.66) minutes and 16.5(±4.28) minutes, p = <0.001. Conclusions. Patients who were informed by 3D-VR method before colonoscopy had statistically significantly better bowel preparation, as well as reduced procedure time and possibly increased detection rates of polyps and adenomas.
Correction of Constricted Ear – Case Report
Authors: Damjanoska Krstikj Ljubinka , Rajkovska Kimovska Ana , Krsteska Roza , Stevkovska Mare 
Published: June 2024

Introduction. Congenital deformities of the outer ear are common; reported incidence are from 1:6000 to 1:6830 newborns. Multitude of corrective procedures are described in the literature. Purpose of the case study. The adequate surgical treatment of the congenital constricted ear remains a challenge. Selected tailor made approach should be employed on case by case basis, thus, in this study we present our case of moderate constricted ear and the used surgical procedures done under general anesthesia, as well as the outcome of the treatment. Case report. A 6 year old girl presented in pediatric and plastic surgery department with complaint of right ear deformity from birth and additional psychological effects such as increased difficulty in social integration and lack of self- confidence. On clinical examination, we considered as constricted ear grade IIB by Tanzel. Two separate procedures under general anesthesia were done. In the first procedure, advancement of the helix and otoplasty was performed; an effective expansion, of about 1 cm in the length of the pinna was obtained. In the second procedure, about 0.5 cm expansion of the helix was performed, and also the breadth of the pinna. Conclusion. In our case, combination of Mustardé suture, helix advancement and helix cartilage graft in moderate constricted ear were a useful surgical option, producing aesthetically good results in a simple and effective way.
Better Guidelines and Policies: AAP’s Partnership for Policy Implementation
Authors: Lehmann Christoph U. , Adams William G. , Chaparro Juan D. , Fiks Alexander G. , Grout Randall W. , Leu Michael G. , Mendonca Eneida A. , Michel Jeremy J. , Okechukwu Kymika , Salmon Jeremiah , Sharifi Mona , Downs Stephen M. 
Published: June 2024

OBJECTIVES
In 2005, the American Academy of Pediatrics founded the Partnership for Policy Implementation (PPI). The PPI has collaborated with authors to improve the quality of clinical guidelines, technical reports, and policies that standardize care delivery, improve care quality and patient outcomes, and reduce variation and costs.

METHODS
In this article, we describe how the PPI trained informaticians apply a variety of tools and techniques to these guidance documents, eliminating ambiguity in clinical recommendations and allowing guideline recommendations to be implemented by practicing clinicians and electronic health record (EHR) developers more easily.

RESULTS
Since its inception, the PPI has participated in the development of 45 published and 27 in-progress clinical practice guidelines, policy statements, technical and clinical reports, and other projects endorsed by the American Academy of Pediatrics. The partnership has trained informaticians to apply a variety of tools and techniques to eliminate ambiguity or lack of decidability and can be implemented by practicing clinicians and EHR developers.

CONCLUSIONS
With the increasing use of EHRs in pediatrics, the need for medical societies to improve the clarity, decidability, and actionability of their guidelines has become more important than ever.
Characteristics of the recommendations included in the clinical practice guidelines commissioned by the Colombian Ministry of Health (2013-2021): A systematic review
Authors: Muñoz-Flórez Anamaría , Balcázar-Muñoz Ángela Manuela , Villar Juan Carlos , Rodríguez Felipe Angel , Queremel-Milani Daniel 
Published: June 2024

Introduction: Over the last decade, and following the publication of an instructional methodological guide for the development of clinical practice guidelines (CPG), the Colombian Ministry of Health and Social Protection (CMHSP) commissioned the development or update of a series of CPGs. However, to date, there is no diagnosis of the characteristics of the recommendations made in such CPGs.
Objective: To explore the characteristics of the recommendations included in CPGs commissioned by the CMHSP between 2013 and 2021.
Materials and methods: A systematic review of Colombian CPGs published between 2013 and 2021 was conducted. Only CPGs reporting the level of certainty of the supporting evidence and the strength of the recommendation in at least 70% of its recommendations using the GRADE approach were included. Information on the certainty, direction, and strength of each recommendation was extracted. Additionally, the agreement between the language used (wording) in the recommendation and its strength was assessed in a random sample of 20% of the recommendations.
Results: Of the 59 CPGs retrieved, 36 met the inclusion criteria, for a total of 1 609 recommendations analyzed. The median number of recommendations per CPG was 41 (IQR: 27-55), 81.4% were in favor, 62.77% were classified as strong, 58.23% were based on low/very low-quality evidence, and 56.06% were intended for treatment. Furthermore, 51.39% and 74.60% of strong and weak recommendations were based on low/very low-quality evidence, respectively. Regarding the analysis of their wording, there was disagreement between the language and the certainty of evidence in 50.31% of the 324 recommendations randomly reviewed.
Conclusions: The CPGs evaluated include a relatively high number of recommendations, most of them in favor and rated as strong but based on low-quality evidence, which may be controversial and generate barriers to their understanding and implementation. These results also indicate the need to improve adherence to the CPG development methodology and standards among Colombian CPG development groups.
The Effect of Object Thickness in Numerical Reflectance and Transmittance using Finite Difference Time Domain (FDTD)
Authors: Gunawan Vincensius 
Published: June 2024

The electromagnetic waves could be simulated using finite difference time domain. This simulation method based on Maxwell equations. Here, the fields were spatially discretized along time discretization. This was the basic concept for updating the fields in every time step. Since the reflection and transmission of electromagnetic waves were the basic phenomena for optical studies of the waves in materials, we studied the reflectance and transmittance. In FDTD, the reflection and transmission could be calculated using Fourier transformation. We found that the thickness of the object which was inserted to the system affected the reflection and transmission significantly. If the thickness of the object became thicker, then there also increased the appearance frequency of the reflectance with the similar values. It was also happened to the transmittance.
MEDIACIÓN ORGANIZACIONAL. CASO: CENTRAL DE ABASTO DE VILLAHERMOSA, TABASCO
Authors: GÓMEZ IZQUIERDO SILVIA CRISTINA 
Published: June 2024

En este texto se realiza un análisis del impacto que logran alcanzar los Métodos Alternos de Resolución de Controversias en los conflictos organizacionales, fijando transcendencia entre los individuos en su día a día. Demostrando los beneficios que pueden obtener las partes involucradas en un conflicto, teniendo como resultado soluciones que aporten un ganar-ganar y la satisfacción de las partes involucradas. El presente trabajo, expone mediante el Caso de la Central de Abasto Villahermosa en Tabasco, México, la eficacia del procedimiento de la mediación organizacional, resaltando las técnicas y herramientas de la justicia alternativa mediante los mecanismos alternativos, refiere a una concepción distinta del conflicto para y con las partes involucradas, con el objeto de cubrir intereses y necesidades de ambas partes que también integre una comunicación eficaz para el desarrollo organizacional.
In this text, an analysis is carried out of the impact that Alternative Dispute Resolution Methods achieve in organizational conflicts, establishing significance between individuals in their daily lives. Demonstrating the benefits that the parties involved in a conflict can obtain, resulting in solutions that provide a win-win and satisfaction of the parties involved. The present work exposes, through the Case of the Central de Abasto in Tabasco, Mexico, the effectiveness of the organizational mediation procedure, highlighting the techniques and tools of alternative justice through alternative mechanisms, referring to a different conception of the conflict for and with the parties involved, in order to cover the interests and needs of both parties that also integrates effective communication for organizational development.