bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transitional lumbosacral vertebrae in black Norwegian elkhound and Brittany dogs: Clinical findings and its association with degenerative lumbosacral stenosis
Authors: Berg Jon Andre , Saevik Bente Kristin , Lingaas Frode , Trangerud Cathrine 
Published: February 2025

Abstract

Background
Lumbosacral transitional vertebra (LTV) is a congenital anomaly in dogs and have been proposed to be associated with cauda equina syndrome (CES) in German Shepherd dogs. This prospective study, including 32 dogs from two breeds, aims to investigate if LTV is associated with lower back pain in dogs. The study compared owners’ assessment of their dogs’ well-being and clinical evaluation with advanced diagnostic imaging to identify changes that might explain clinical findings.

Results
Dogs with LTV type 2 (57.0%) and with LTV type 3 (70.0%) exhibited mild lower back pain, which was significantly more frequent (P = 0.012) compared to dogs with LTV type 0 and LTV type 1. Advanced diagnostic imaging identified a plausible cause for this pain. Dogs diagnosed with LTV types 2 and 3 with lower back pain tended to be lighter (median 14.50 kg) and younger (median 4.10 years) than breeds typically reported for degenerative lumbosacral stenosis (DLSS). Based on the owners’ assessment of their dogs, they considered them pain-free.

Conclusions
The study identified a correlation between LTV types 2 and 3 and lower back pain in these dog breeds. Advanced diagnostic imaging findings confirmed that dogs with these LTV types were more likely to exhibit pathological changes associated with DLSS.
Deep neural network modeling attacks on arbiter-PUF-based designs
Authors: Wang Huanwei , Hao Weining , Tang Yonghe , Zhu Bing , Dong Weiyu , Liu Wei 
Published: February 2025

Abstract
Physical Unclonable Functions (PUFs) are novel circuit structures that provide hardware security solutions in application areas such as chip design and IoT, due to characteristics of their lightweight, key-free and tamper-resistant. PUFs are not immune to threats like machine learning modeling attacks and side channel modeling attacks. Strong PUFs are susceptible to classical machine learning attacks, however, machine learning’s effectiveness in attacking complex structured strong PUFs is limited, and its efficiency is relatively low. Side-channel modeling attacks, on the other hand, incur high implementation costs. Hence, employing deep learning for modeling attacks becomes an effective and cost-efficient choice when attacking complex structured PUFs. In this paper, we introduce a method that employs deep neural network to assess the modeling resilience of combination logic operation-based PUFs with APUFs as components for the first time. We employed a 4-layer DNN model to investigate the security resilience of PUF models involving any combination of OR AND and XOR logical operations. We explored the security regular patterns of modeling resilience. We have demonstrated for the first time that bias in PUF responses can reduce or destroy the security of PUFs. OR or AND logic operations do not provide any security benefit in PUF design, while XOR operations enhance the security of PUFs.
Severe subacute combined degeneration of the spinal cord resulting from nitrous oxide (N2O) abuse: a case series
Authors: Adam Lucas C. , Grobelny Anuschka , Hahn Katrin , Audebert Heinrich J. , Krause Patricia , Franke Christiana , Ruprecht Klemens 
Published: February 2025

Abstract

Objective
To describe the demographic, clinical, laboratory, and radiological findings, and the clinical course of seven patients with severe N2O-induced subacute combined degeneration of the spinal cord (SACD).

Methods
Retrospective study with prospective follow-up of patients with SACD associated with N2O abuse presenting at a single center between 2014 and 2024.

Results
The median age (range) of the seven patients (one woman, six men) was 24 (18–33) years. Prior to disease onset, patients had consumed N2O daily over a median (range) of 12 (3-20) weeks, with a mean (SD; range) inhalation dosage of 2376.7 (2872.7; 160–9000) g of N2O per day. Clinical presentations included paresthesia and paresis in the legs and gait disturbances. All patients exhibited characteristic signal alterations in the posterior columns spanning from C1 to T10 on T2-weighted spinal MRIs. Electrophysiology demonstrated polyneuropathies in all but one patient. Vitamin B12 levels were decreased in four, but normal in three patients. Methylmalonic acid levels were elevated in all patients. Although the median (interquartile range [IQR]) modified Rankin Scale score improved from 3.0 (3.0–4.0) at baseline to 1.0 (1.0–2.0; p < 0.05, Wilcoxon matched-pairs signed-rank test) at follow-up after the start of vitamin B12 supplementation, all five patients who could be examined on follow-up exhibited persistent deficits on the last follow-up assessment at a median (range) of 5 (3-116) months after disease onset.

Conclusions
N2O abuse over a few weeks can lead to severe SACD. The diagnosis is supported by characteristic findings on spinal MRI and elevated methylmalonic acid levels, while normal vitamin B12 levels do not rule out N2O-induced SACD. Although there was some clinical improvement upon cessation of N2O abuse and vitamin B12 supplementation, residual deficits persisted.
Piero Sraffa and Counterfactuals: A View from Sraffa's Unpublished Papers in the Late 1920s
Authors: Kurz Heinz D. , Salvadori Neri , Signorino Rodolfo 
Published: February 2025

Abstract
This article reconstructs Sraffa's position with regard to counterfactual reasoning in the second half of the 1920s as documented by his up until now unpublished papers. While Sraffa did not use the term “counterfactual,” it is precisely this concept he had in mind when examining certain non-purely-observational propositions and discussing responses to “what if?” questions. He did so with respect to different contexts, but his attention focused primarily on the marginal theory of value and distribution. At an early time he showed with regard to the latter that any simple analysis of single causation in terms of counterfactuals is difficult to sustain. Sraffa's method of inquiry can be interpreted as an instance of abductive reasoning. The article confirms Sen's interpretation that Sraffa met counterfactual reasoning with suspicion, since it might easily lead to highly misleading propositions. But Sraffa's manuscripts do not support the extreme view (not entertained by Sen) that any counterfactual reasoning ought to be rejected.
One Man a Committee Does Not Make: Henry Manne, the AEA-AALS Joint Committee, and the Struggle to Institutionalize Law and Economics
Authors: Gindis David , Medema Steven G. 
Published: February 2025

Abstract
In 1965, Henry Manne convinced the Association of American Law Schools and the American Economic Association to establish an ad hoc joint committee to explore the possibilities of collaborative efforts between economists and legal scholars. This article examines the origins and activities of the joint committee and reveals that its work was far less about promoting increased interaction between economists and legal scholars than about a conscious attempt to use this committee to help fashion a particular form of law and economics that would reshape legal analysis in a way consistent with Manne's vision. Though the committee's effective life was very short and its direct influence negligible, the lessons learned informed Manne's subsequent efforts to institutionalize law and economics within the legal academy.
Dynamic Assessment of Local Abdominal Tissue Concentrations of Cisplatin During a HIPEC Procedure: Insights from a Porcine Model
Authors: Harlev Christina , Bue Mats , Petersen Elisabeth Krogsgaard , Jørgensen Andrea René , Bibby Bo Martin , Hanberg Pelle , Schmedes Anne Vibeke , Petersen Lone Kjeld , Stilling Maiken 
Published: February 2025

Abstract

Background
This study aimed to establish a feasible large porcine model for dynamic assessment of cisplatin concentrations in carcinomatosis-relevant abdominal tissues using microdialysis during and after HIPEC combined with cytoreductive surgery.

Methods
In total, eight pigs underwent open abdominal cytoreductive surgery followed by HIPEC. Microdialysis was employed for dynamic cisplatin concentration sampling in abdominal organs and tissue. Cisplatin dialysate concentrations were analyzed using the UPLC-MS/MS method. STATA (version 18.0) was used to perform a two-compartment model with a zero-order distribution to analyze pharmacokinetic parameters.

Results
Detectable cisplatin concentrations in the evaluated target tissues persisted for at least 6 h post-HIPEC. Higher concentrations were found in superficial tissues; however, the difference was not statistically significant. The cisplatin concentrations were comparable for the stomach, rectum, and liver but higher in the peritoneal lining of the abdominal wall, with the lowest median average peak concentration (C
max) in the rectum (0.50 µg/mL) and the highest median C
max in the peritoneum (2.80 µg/mL). No statistically significant differences in cisplatin area under the curve from time zero to the time of the last sample collection (AUC0–last) were found between any of the abdominal compartments except the peritoneal lining of the abdominal wall, which was significantly higher compared with most of the other abdominal tissues {smallest difference; peritoneum 1/liver 2; 1.96 [95% confidence interval (CI) 0.90; 4.26, P = 0.09] and largest difference; peritoneum 3/rectum profound; 4.60 [95% CI 1.94; 10.90, P = 0.001]}.

Conclusions
Our investigation revealed comparable cisplatin concentrations across abdominal organ surfaces, except higher concentrations in the peritoneal lining of the abdominal wall than in the stomach, rectum, and liver. This model holds promise for future research into HIPEC interventions and anticancer effectiveness.
Performance and Physiological Effects of Race Pace-Based versus Heart Rate Variability-Guided Training Prescription in Runners
Authors: Ranieri Luis Eduardo , Casada Arturo , Martin Diana , Trujillo-Colmena Daniel , Gil-Arias Alexander , Kenneally Mark , Jiménez Alfonso 
Published: February 2025

ABSTRACT

Purpose
The aim of the present study was to compare performance and physiological effects, and inter-individual response variation in performance and its physiological determinants between heart rate-based (HR), race pace-based (RP) and heart rate variability-based (HRV) training prescription approaches in recreational distance runners.

Methods
Twenty-eight participants completed a 6-week endurance training intervention after being randomly assigned to three groups: HR (n = 9), RP (n = 9), and HRV (n = 10) training prescription approaches.

Results
No interaction effects between groups were observed. Main time effects were found for absolute and relative V̇O2max, running economy (RE), speeds associated to the first (sVT1) and second ventilatory thresholds (sVT2) and 7 km time trial performance (TT) (p < 0.001, 0.88 ≤ d ≤ 2.67). The RP group improved TT (p < 0.05, ES = 1.07), showing greater effectiveness in enhancing maximal aerobic speed and fat mass reduction, but did not consistently improve physiological parameters like sVT2 or RE. The HRV method increased sVT2 (p < 0.01, ES = 1.34) and was more successful in boosting sVT1 and V̇O2max, although it resulted in an increase in fat mass. Training load was similar between groups (p > 0.05), and a pyramidal training intensity distribution model was found in all groups. The lowest inter-individual response variation in TT was found in the RP group (coefficient of variation [CV] = 0.82), whereas the HRV group demonstrated a lower variation in relative V̇O2max (CV = 0.75) and sVT2 (CV = 0.79).

Conclusions
The RP approach is an effective and useful training prescription method for optimising performance in recreational runners, while the HRV method proves valuable for enhancing key physiological markers.
Feasibility, Acceptability, and Effectiveness of Physically Active Lessons in Secondary Education: ACTIVE CLASS Pilot Study
Authors: Ruiz-Hermosa Abel , Sánchez-Oliva David , Grao-Cruces Alberto , Medrano María , González-Pérez María , Martín-Acosta Fátima , Camiletti-Moirón Daniel 
Published: February 2025

ABSTRACT

Introduction
The aim of this study was to test the feasibility, acceptability, and effectiveness of a physically active learning (PAL) intervention (ACTIVE CLASS pilot study) to improve physical health and cognitive and academic performance, increase physical activity (PA) levels, and reduce sedentary time (ST) in adolescents, and to analyze the distribution of activity intensity during a PAL lesson and assess differences with physical education lessons.

Methods
A quasi-experimental study was conducted including 77 students aged 12–14 yr from two Spanish secondary schools. The ACTIVE CLASS pilot program consisted of integrating a weekly PAL lesson into mathematics lessons for 4 wk. Changes in body composition (body mass index and waist circumference), physical fitness (cardiorespiratory and muscular fitness), executive functions (inhibition, working memory, and cognitive flexibility), and mathematical fluency were measured. Accelerometer-based ST and PA were measured in the intervention group. The feasibility and acceptability of the intervention were assessed using self-reported questionnaires for teachers and students. Repeated-measures analyses of variance were used to test the effects of the intervention.

Results
There were no significant improvements in body composition, fitness, and cognitive and academic performance when comparing the intervention and control groups. The inclusion of the PAL intervention significantly increased average PA levels and reduced ST during the school day, and no significant differences were found in accelerometer-based variables between physical education and PAL lessons. In fact, PAL lessons could provide up to 17 min of moderate/vigorous PA. In addition, teachers and students reported good feasibility and acceptability of the PAL intervention.

Conclusion
The findings support further research with a longer-term intervention and a larger sample size to determine the true potential of PAL for adolescents’ physical health, cognition, and academic performance.
Measuring Career Well-Being on Working Mothers: Adaptation of Well-Being at Work Scale
Authors: Anwar Hilwa , Suhariadi Fendy , Fajrianthi Fajrianthi 
Published: February 2025

AbstractÂ This research aimed to conduct the adaptation and validation of the Well-Being at Work Scale (WBWS) in order to ready it for implementation as the instrument to measure career well-being on working mothers as respondents in Indonesia. The career well-being approach was based on the concept of general well-being which included affective and cognitive components. The respondents were mothers working full-time in the formal sector and had fulfilled the requirement of several pre-determined criteria. The collected research data was analyzed with the confirmatory factor analysis in order to obtain instrument reliability and validity. Based on the analysis, results were obtained that the WBWS model adaptated had fulfilled the goodness-of-fit criteria, meaning that there was compatibility between the developed model and the empirical data. Furthermore, this research was hoped to provide contribution in the measurement and development of research of career well-being on working mothers.Â
Predictors of survival in pediatric intensive care unit in a low-income country: A retrospective cohort study
Authors: Ebrahim Mohamedawel Mohamedniguss , Mohamed Abdikarin Ahmed , Mohammedamin Mohammed Mustefa 
Published: February 2025

Background
The goal of a pediatric intensive care unit is to treat life-threatening illnesses. Yet, there is a lack of data on survival rates and factors influencing survival in pediatric intensive care units (PICUs) in low-income countries like Ethiopia.

Objective
The purpose of this study was to evaluate survival and its predictors in the pediatric intensive care unit of Ayder Comprehensive Specialized Hospital, Tigray, Ethiopia.

Method
A retrospective cohort study was implemented on a total of 223 patients admitted to the PICU from September 2019 to August 2020. Using a checklist, trained healthcare workers gathered secondary data from patient charts. The dependent variable was time-to-death. EpiData 4.6 and STATA 16 were used for data entry and data analysis, respectively. Descriptive statistics, cumulative incidence, incidence density, median survival time, and adjusted hazard ratio were calculated to describe variables, estimate mortality rate and risk, and identify factors associated with survival. P<0.05 was used to declare a statistically significant relationship.

Result
A total of 46 (20.6%) deaths were recorded in this study. The cumulative incidence of death was higher in patients transferred from the ward to the intensive care unit (34.7%). The death rate was higher in patients with cardiac problems (40.0%), followed by oncological diseases (35.0%) and infectious diseases (27.9%). The adjusted risk of death was 3.3 times higher in pediatric patients with heart problems than in patients without heart problems. Again, the adjusted risk of death in children with a Glasgow Coma Scale (GCS) of 9 to 14 and a GCS below 9 was 2.2 and 2.5 times higher, respectively, than in children with a GCS of 15. Finally, children with endotracheal tubes were about five times more likely to die than children without endotracheal tubes.

Conclusion
It’s critical to diagnose and treat cardiac issues in pediatric patients as early as possible. Patients with low GCS scores require careful observation. Alternative strategies should be taken into consideration in order to lessen the need for endotracheal tubes and enhance results.
Naratuximab emtansine (IMGN529; Debo 1562) Drug Description
Authors:   Sunvalley Communication, LLC / ADC Review, Hofland Peter 
Published: February 2025

Naratuximab emtansine, also known as IMGN529 and Debio 1562 is an antibody-drug conjugate (ADC) or immunoconjugate that consists of a humanized IgG1 antibody K7153A against the cell-surface antigen CD37, a member of the tetraspanin superfamily of cell surface antigens found on B-cell malignancies, that is covalently linked via the uncleavable, maleimide-derived thioether-based linker SMCC to the maytansinoid DM1, with potential pro-apoptotic and cytotoxic activities.
Spray and forced coagulation mode endoscopic submucosal dissection for early gastric neoplasms: a multicenter randomized controlled trial
Authors: Esaki Mitsuru , Sumida Yorinobu , Maehara Kosuke , Yamaguchi Daisuke , Nishioka Kei , Homma Hitoshi , Inada Taisuke , Shiotsuki Kazuo , Fukuda Shin-Ichiro , Akiho Hirotada , Nomura Tadahiro , Mizuta Yumi , Ishida Satoshi , Fujimoto Shun , Kimura Shunichiro , Tanaka Yuichiro , Hata Kaori , Shiga Noriko , Iwasa Tsutomu , Kimura Yusuke , Nakamura Norimoto , Suzuki Yusuke , Minoda Yosuke , Bai Xiaopeng , Tanaka Yoshimasa , Hata Yoshitaka , Ogino Haruei , Chinen Takatoshi , Ihara Eikichi , Tagawa Koshiro , Ogawa Yoshihiro 
Published: February 2025

Objectives:
Controlling intraoperative bleeding during endoscopic submucosal dissection (ESD) is essential to ensure the safety and reliability of the procedure. ESD in spray coagulation mode (SCM-ESD) is expected to ensure more effective bleeding control. This study aimed to investigate the superiority of SCM-ESD over conventional forced coagulation mode ESD (FCM-ESD) in terms of hemostatic ability for treating early gastric neoplasms (EGNs).

Methods:
This multicenter randomized controlled trial (Spray-G Trial) was conducted at five Japanese institutions. Patients with intramucosal EGNs were enrolled and randomly assigned to either the SCM-ESD or FCM-ESD group. The primary outcome was ESD completion with an electrosurgical knife alone, that is, without the use of hemostatic forceps. The number and duration of hemostatic procedures using hemostatic forceps, procedure time, curability, and adverse events were also evaluated.

Results:
Each group included 65 patients. The rate of ESD completion without using hemostatic forceps was significantly higher for SCM-ESD than for FCM-ESD (83.1% vs. 13.8%, p<0.0001). SCM-ESD and FCM-ESD did not differ significantly in terms of procedure time (48.3 min vs. 56.0 min, p=0.1071), R0 resection (100% vs. 95.4%, p=0.2442), and rate of adverse events (3.1% vs. 6.2%, p=0.6801).

Conclusions:
SCM-ESD significantly improved ESD completion rates for intramucosal EGNs without using hemostatic forceps. SCM-ESD is a promising technique that may streamline ESD by eliminating the need to exchange devices and reducing costs. (UMIN Clinical Trials Registry, Numbers: UMIN000047353)
Acute night shift work is associated with increased blood pressure and reduced sleep duration in healthy adults
Authors: Seward Sophie L. , Kishman Erin E. , Rynders Corey A. , Broussard Josiane L. 
Published: February 2025

AbstractShift workers have a 40% higher risk for cardiovascular disease (CVD) compared to people who work day shifts. However, the acute impact of shift work on CVD risk factors in free‐living settings remains unclear. We therefore investigated the impact of acute night shift work on factors related to cardiovascular health including blood pressure (BP) and sleep duration. Twenty‐four rotating shift workers (19F, 23 ± 4 y, BMI: 23 ± 3 kg/m2; mean ± SD) participated in a quasi‐randomized crossover study. Assessments were conducted over the course of 1 day shift and one night shift in a free‐living setting. BP was measured every 30 min by an ambulatory monitor. Sleep and wake times were recorded. Mixed effects models were conducted to examine changes in variables between conditions. Acute night shift work was associated with significantly higher 24 h systolic (107 ± 1 vs. 104 ± 1 mmHg; p < 0.0001) and diastolic (67 ± 1 vs. 64 ± 1 mmHg; p < 0.0001) BP, as well as blunted dipping patterns in systolic BP (8 ± 1 vs. 12 ± 1%; p = 0.032), as compared to day shift work. Sleep duration was significantly shorter during the night shift as compared to the day shift (4 h 04 ± 19 min vs. 8 h 22 ± 18 min; p < 0.0001). As little as one night of shift work in a free‐living setting is sufficient to induce multiple CVD risk factors including increased BP and reduced sleep duration in healthy adults. It is critical to identify strategies to prevent or attenuate the negative impact of shift work on CVD risk in a large portion of the working population.