bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lifestyle trajectories in middle-aged adults and their relationship with health indicators
Authors: Roca-Ventura Alba , Solana-Sánchez Javier , Cattaneo Gabriele , Tormos-Muñoz Josep M. , Pascual-Leone Álvaro , Bartrés-Faz David 
Published: June 2024

IntroductionUnderstanding the impact of different lifestyle trajectories on health preservation and disease risk is crucial for effective interventions.MethodsThis study analyzed lifestyle engagement over five years in 3,013 healthy adults aged 40-70 from the Barcelona Brain Health Initiative using K-means clustering. Nine modifiable risk factors were considered, including cognitive, physical, and social activity, vital plan, diet, obesity, smoking, alcohol consumption, and sleep. Self-reported diagnoses of new diseases at different time-points after baseline allowed to explore the association between these five profiles and health outcomes.ResultsThe data-driven analysis classified subjects into five lifestyle profiles, revealing associations with health behaviors and risk factors. Those exhibiting high scores in health-promoting behaviors and low-risk behaviors, demonstrate a reduced likelihood of developing diseases (p &lt; 0.001). In contrast, profiles with risky habits showed distinct risks for psychiatric, neurological, and cardiovascular diseases. Participant’s lifestyle trajectories remained relatively stable over time.DiscussionOur findings have identified risk for distinct diseases associated to specific lifestyle patterns. These results could help in the personalization of interventions based on data-driven observation of behavioral patterns and policies that promote a healthy lifestyle and can lead to better health outcomes for people in an aging society.
Impact of an improved outdoor space on people with dementia in a hospital unit
Authors: Ng Lorraine , Dyer Suzanne M. , Dawson Suzanne , Laver Kate 
Published: June 2024

IntroductionGardens and outdoor spaces are an important part of institutional environments for people with dementia. However, evidence regarding the benefits these spaces have for people with dementia is still limited. This paper presents the evaluation of the redevelopment of an inaccessible outdoor space into a therapeutic garden on a high dependency psychogeriatric unit in an acute hospital.MethodA Mixed methods evaluation was undertaken. An interrupted time series analysis investigated the impact of the garden on falls and challenging behaviours of patients using routinely collected data. Perspectives of the redeveloped garden were captured through (a) a staff survey and (b) semi-structured interviews with families of patients.ResultsRates of falls and challenging behaviours dropped at the time of the garden opening but showed increasing rates each month both before and after the garden opened. Most staff believed that the garden provided benefits for patients however limited staff time and concerns over patient safety were barriers to use. Families identified four main themes related to garden use including: (1) being outside (2) occupation and identity, (3) being stimulating, and (4) barriers and facilitators.ConclusionThe garden was regarded positively by families and staff however, there were barriers that prevented it from being better utilised. Staff concerns over risk were not reflected in falls and challenging behaviour outcomes. Further research into how barriers to garden use may be overcome is justified.
Histological pattern of tumor inflammation and stromal density correlate with patient demographics and immuno-oncologic transcriptional profile in oral squamous cell carcinoma
Authors: Theofilou Vasileios Ionas , Ghita Ioana , Elnaggar Manar , Chaisuparat Risa , Papadimitriou John C. , Bentzen Soren M. , Dyalram Donita , Lubek Joshua E. , Ord Robert A. , Younis Rania H. 
Published: June 2024

IntroductionOral squamous cell carcinoma (OSCC) is the most prevalent oral malignancy, with emerging interest in the characterization of its tumor microenvironment. Herein, we present a comprehensive histological analysis of OSCC stromal density and inflammation and their relationship with patient demographics, clinicopathologic features and immuno-oncologic signatures.Materials-methodsEighty-seven completely excised OSCC tissues were prospectively collected and scored for histopathologic inflammatory subtypes [HIS]—inflamed (INF), immune-excluded (IE) and immune-desert (ID), peritumoral stromal inflammation (PTSI), and peritumoral stromal fibrosis (PTSF). Scoring of inflammation was complemented by Semaphorin 4D immunohistochemistry. NanoString differential gene expression (DGE) analysis was conducted for eight OSCC cases representative of the inflammatory and stromal subtypes and the demographic groups.ResultsPTSF correlated with male gender (p = 0.0043), smoking (p = 0.0455), alcohol consumption (p = 0.0044), increased tumor size (p = 0.0054), and advanced stage (p = 0.002). On the contrary, PTSI occurred predominantly in females (p = 0.0105), non-drinkers (p = 0.0329), and small tumors (p = 0.0044). Transcriptionally, decreased cytokine signaling, and oncogenic pathway activation were observed in HIS-IE. Smokers and males displayed decreased global immune-cell levels and myeloid-cell predominance.ConclusionOur work describes OSCC stromal and inflammatory phenotypes in correlation with distinct patient groups and DGE, highlighting the translational potential of characterizing the tumor microenvironment for optimal patient stratification.
Exploring the impact of sleep on emotional and physical well-being in professional cricketers: a cohort study over an in-season training period
Authors: Grewal S. , Theijse R. T. , Dunlop G. , van Deurzen D. F. P. , van den Bekerom M. P. J. , Klautz R. J. M. , Lefebvre R. P. , Munsami D. , Grewal N. 
Published: June 2024

BackgroundProfessional athletes navigate a multitude of unique challenges associated to sport-specific factors (e.g., training, travel and competition) and non-sport factors (e.g., performance pressure, stress and anxiety) that can interfere with healthy sleep behaviors. Sleep plays a key role in proper biopsychosocial development as well as short- and long-term biological, physical, psychological, and cognitive health. As poor sleep quality is known to impair proper brain function, this study aimed to investigate the effect of sleep quality on a professional athlete's ability to train, recover, and perform, as well as their overall emotional and physical well-being.MethodsA cohort study was performed in 40 professional male cricket athletes from the Dutch national cricket team (mean age 26.5 ± 5.1 years). The athletes were monitored across a 22 weeks in-season training period. Sleep quality and overall emotional and physical well-being were assessed using daily sleep diaries and questionnaires which scored the readiness to train, stress levels, fatigue, muscle soreness and flu symptoms respectively. Quality of sleep and subsequent association with the consecutive elements of the well-being questionnaire were assessed through statistical using the student t-test and clinical differences with the methodology of Osoba and colleagues: &lt;5% “no change”, 5%–10% “little change”; 10%–20% “moderate change”; and &gt;20% “very much change”.ResultsThe results demonstrated that the professional athletes assessed their sleep quality as average with a mean score of 3.4 out of 5. Lower perceived quality of sleep (&lt;75th percentile) was correlated with a decreased readiness to train (mean score 3.2 [IQR: 3.0–4.0] vs. 3.5 [IQR: 3.0–5.0]; P &lt; 0.001) and increased extent of muscle soreness (2.7 [IQR: 2.0–3.0] vs. 2.3 [IQR: 2–3]; P &lt; 0.001), stress level (mean score 2.3 [IQR: 2.0–3.0] vs. 1.9 [IQR: 1.0–2.0]; P &lt; 0.001) and perceived fatigue (mean score 2.9 [IQR: 2.0–3.0] vs. 2.3 [IQR: 2.0–3.0]; P &lt; 0.001). Likewise, in patients with lower perceived quality of sleep, the proportion of players presenting with flu symptoms increased over 4-fold (4.1% vs. 17%; P &lt; 0.001).ConclusionsThis study highlights that good sleep quality positively influences the overall emotional and physical well-being of professional athletes. Our results emphasize the importance of targeted sleep interventions to improve sleep quality and subsequently optimize psychological and physiological wellness.
Influence of age, gender, and willingness to adopt former foodstuffs on the perception of Italian farm animal veterinarians
Authors: Diaz Vicuna Elena , Srikanthithasan Karthika , Odore Rosangela , Massaglia Stefano , Merlino Valentina Maria , Giorgino Andrea , Ozella Laura , Schiavone Achille , Massacci Francesca Romana , Mota-Gutierrez Jatziri , Forte Claudio 
Published: June 2024

BackgroundVeterinarians play an essential role in improving animal care, as they are often viewed as trusted advisors, particularly in relation to disease control and management; however, little is known about veterinarians’ perceptions and attitudes toward alternative feeds. The aim of this study was to investigate the influence of age, gender, and willingness to adopt on the attitudes of livestock veterinarians toward the use of alternative feeds in farm animals.MethodsA total of 136 active veterinarians completed the online survey, distributed through the main veterinary associations in Italy. The questionnaire contained items on dietary recommendation, awareness, benefit and safety perceptions, and a willingness to adopt former foodstuffs (FFs), complemented with socio-demographic questions.ResultsAlmost 90% of the population reported a willingness to adopt FFs as feed. Men and women did not share the same perceptions of the nutritional composition of FFs, while the importance of product availability was found to be a key factor driving the age difference. Participants willing to adopt FFs as feed linked positive attitudes to attributes such as digestibility, energy intake, and positive social implications.ConclusionOur findings provide a basic background on the current use of the FFs in Italy and suggest the need for the development of educational programs and marketing strategies to enhance the acceptability of FFs in farm animals to ultimately promote the transition toward more sustainable animal production. This study has limitations, including the number of recorded responses and reliance on national estimates. Future research is needed to investigate the perceptions of farmers and animal nutritionist from different countries. This could provide a more detailed picture of the current situation in Europe about the potential of using FFs in farm animals’ feed, thus further contributing toward a greener and safer livestock production sector.
Assessment of health problems of sheep and goats based on ante-mortem and post-mortem inspection at Addis Ababa Abattoir, Ethiopia
Authors: Bekele Atoma Tizeta , Szonyi Barbara , Haile Aklilu Feleke , Fries Reinhard , Baumann Maximillian P. O. , Randolph Delia Grace 
Published: June 2024

IntroductionEthiopia has a rapidly growing small ruminant sector, which faces low productivity due to husbandry practices and poor health condition of the animals. A study was conducted in Ethiopia’s largest municipal abattoir with the objective to assess the health problems of sheep and goats presented for slaughter using standard ante-mortem and post-mortem methodology.MethodsA cross-sectional study using systematic random sampling was conducted on 384 sheep and 384 goats from January to July 2014.ResultsSoiled skin (69.1%), poor body condition (24.3%), and nostril discharge (19.5%) were common among both species at ante-mortem examination. Gross lesions were frequent in livers (39.7%) and lungs (37.2%), while pneumonia (18.1%) and adhesions (13.8%) were frequent in the lungs of sheep and goats, indicating stress-related illness. Parasitic lesions, especially fasciolosis (19.3%) and hydatid cysts (8.1%) were significantly more common in sheep livers (p 0.05). The direct financial loss from lesions in both species was 1,077,015 ETB or 53,851 USD per year, most of which was estimated to occur from carcass bruising.DiscussionThe findings indicate that reducing parasite burden and preventing carcass bruising through improved handling could significantly increase the profitability of the small ruminant meat sector in Ethiopia.
The Madrid Posterior Component Separation: An Anatomical Approach for Effective Reconstruction of Complex Midline Hernias
Authors: De Luca Marcello , Medina Pedrique Manuel , Morejon Ruiz Sara , Munoz-Rodriguez Joaquin M. , Robin Valle de Lersundi Alvaro , Lopez-Monclus Javier , Blázquez Hernando Luis Alberto , Garcia-Urena Miguel Angel 
Published: June 2024

IntroductionIn recent years, Posterior Component Separation (PCS) with the Madrid modification (Madrid PCS) has emerged as a surgical technique. This modification is believed to enhance the dissection of anatomical structures, offering several advantages. The study aims to present a detailed description of this surgical technique and to analyse the outcomes in a large cohort of patients.Materials and MethodsThis study included all patients who underwent the repair of midline incisional hernias, with or without other abdominal wall defects. Data from patients at three different centres specialising in abdominal wall reconstruction was analysed. All patients underwent the Madrid PCS, and several variables, such as demographics, perioperative details, postoperative complications, and recurrences, were assessed.ResultsBetween January 2015 and June 2023, a total of 223 patients underwent the Madrid PCS. The mean age was 63.4 years, with a mean BMI of 33.3 kg/m2 (range 23–40). According to the EHS classification, 139 patients had a midline incisional hernia, and 84 had a midline incisional hernia with a concomitant lateral incisional hernia. According to the Ventral Hernia Working Group (VHWG) classification, 177 (79.4%) patients had grade 2 and 3 hernias. In total, 201 patients (90.1%) were ASA II and III. The Carolinas Equation for Determining Associated Risks (CeDAR) was calculated preoperatively, resulting in 150 (67.3%) patients with a score between 30% and 60%. A total of 105 patients (48.4%) had previously undergone abdominal wall repair surgery. There were 93 (41.7%) surgical site occurrences (SSO), 36 (16.1%) surgical site infections (SSI), including 23 (10.3%) superficial and 7 (3.1%) deep infections, and 6 (2.7%) organ/space infections. Four (1.9%) recurrences were assessed by CT scan with an average follow-up of 23.9 months (range 6–74).ConclusionThe Madrid PCS appears to be safe and effective, yielding excellent long-term results despite the complexity of abdominal wall defects. A profound understanding of the anatomy is crucial for optimal outcomes. The Madrid modification contributes to facilitating a complete retromuscular preperitoneal repair without incision of the transversus abdominis. The extensive abdominal wall retromuscular dissection obtained enables the placement of very large meshes with minimal fixation.
Use of thigh fascia autograft for repairing a through-and-through soft tissue defect in the alveolar process: a clinical case
Authors: Alishlalov S. A. , Sysolyatin S. P. , Serebrov T. V. , Handzratsyan A. S. 
Published: June 2024

Relevance. In most cases, soft tissue defects can be addressed using standard local flap transposition methods. However, large defects and/or those with scar tissue changes, through-and-through defects involving destruction of both vestibular and palatal cortical plates, defects penetrating into the nasal cavity, and similar situations necessitate unconventional solutions utilizing external graft materials.Clinical case description. This clinical case details the use of an autograft from the wide fascia of the thigh (Fascia lata) to repair an atypical defect of the alveolar process in the maxilla, specifically in the area of teeth 1.2 and 1.1. This defect exhibited through penetration between the vestibule of the oral cavity and the oral cavity proper, along with a significant deficiency of local tissues required for defect closure. The results of clinical, instrumental, and CT examinations conducted before and after the surgical intervention are presented.Results. Objective clinical studies conducted three months post-operation showed complete closure of the defect in the alveolar process of the maxilla, with full epithelization in the postoperative intervention area.
Estimasi Harga Bawang Merah Dengan Menggunakan Data Harga Pasar (Suatu Kasus di Desa Sukasari Kidul, Kecamatan Argapura, Kabupaten Majalengka, Provinsi Jawa Barat)
Authors: Hoirunisa Mila , Marina Ida , Sulaksana Jaka 
Published: June 2024

Penelitian ini bertujuan untuk : (1) Menganalisis kondisi gambaran umum produksi bawang merah di kelompok Tani Mandiri (2). Menganalisis estimasi kenaikan harga bawang merah dengan menggunakan data harga pasar pada periode sebelumnya. Penelitian ini dilakukan di Kelompok Tani Mandiri Desa Sukasari Kidul Kecamatan Argapura Kabupaten Majalengka. Metode yang digunakan yaitu deskriftif kuantitatif dengan teknik penentuan responden Sampling Jenuh sebanyak 18 orang petani bawang merah yang tergabungÂ di Kelompok Tani Mandiri Desa Sukasari dan 10 orang pedagang di pasar terdekat: (1). Gambaran pelaksanaan penanaman benih bawang merah Batu Ijo di Kelompok Tani Mandiri telah dilakukan dengan baik, terarah dan teratur. Hal ini sesuai dengan aturan atau tata cara pelaksanaan penangkaran benih bawang merah pada umumnya. (2). Pada periode Januari 2017 â€“ Desember 2019 pola perkembangan harga bawang merah di Kota Majalengka mengalami peningkatan 5%. Peramalan harga bawang merah di Kota Majalengka memperkirakan adanya tren positif setiap bulan pada tahun 2021 dengan rata rata peningkatan 1% per bulan.
NILAI TAMBAH USAHA INDUSTRI TEMPE DAN STRATEGI PENGEMBANGANNYA (Studi Kasus Di Usaha Home Industri Tempe Bapak Syam Desa Sirnajaya Kecamatan Tarogong Kaler Kabupaten Garut)
Authors: ABDILAH MOCH HABIB , KS KARYANA , YOHANA ANA 
Published: June 2024

This research was conducted with the aim of knowing the business processing system of the tempe industry, to find out how much added value is obtained from processing soybeans into tempeh, and to determine the strategy for developing the tempe industry business. The data analysis used is a case study descriptive method. The results of the research value added tempeh business is Rp. 5.136/kg. And for the added value of the workers, namely Rp. 1.489/kg. As for the development method, it shows that the company's internal factors (strengths and weaknesses) reach -0.41, while the external factors (opportunities and threats) of the company reach 0.43. The strategy that needs to be implemented is the W-O (Weaknessis-Opportunity) strategy. The focus of this strategy is aimed at improving internal weaknesses by taking advantage of external opportunities. To obtain higher income, this business must increase production, as well as optimize sales by utilizing social media as a means of production.Â Â
Faktor-Faktor yang Mempengaruhi Pola Konsumsi Pangan di Kabupaten Garut (Suatu Kasus pada Rumah Tangga Peserta Program Pekarangan Pangan Lestari)
Authors: Taenasah Erna , Dasipah Euis , Gantini Tuti 
Published: June 2024

Pola konsumsi pangan masyarakat saat ini menunjukkan bahwa kualitas dan kuantitasnya belum terpenuhi. Tujuan penelitian ini adalah untuk mengetahui karakteristik rumah tangga P2L di Kabupaten Garut, mengetahui pengaruh secara simultan dan secara parsial antara pendidikan ibu rumah tangga, ukuran keluarga, pengetahuan gizi ibu rumah tangga, pendapatan rumah tangga dan pengeluaran pangan rumah tangga terhadap pola konsumsi pangan (TKE,TKP, skor PPH) rumah tangga P2L di Kabupaten Garut. Metode yang digunakan adalah survey dengan mengambil sampel sebanyak 100 rumah tangga. Untuk menguji hipotesis dalam penelitian ini digunakan analisis jalur.Hasil penelitian menunjukkan bahwa pada umumnya umur peserta program P2L berada pada kelompok usia produktif dengan tingkat pendidikan tamatan SD dan jumlah anggota keluarga 3-4 orang. Rata-rata tingkat pengetahuan pangan dan gizi ibu rumah tangga berada pada kategori cukup. Rata-rata tingkat konsumsi energi dan protein rumahtangga peserta P2L berada pada kategori defisit ringan. Sebanyak 22% rumahtangga sudah memenuhi target konsumsi pangan jika dilihat dari skor PPH. Faktor-faktor yang berpengaruh nyata terhadap TKE rumahtangga P2L adalah ukuran keluarga (X2) dan pengeluaran pangan (X5). Faktor-faktor yang berpengaruh nyata terhadap TKP adalah pengeluaran pangan (X5). Faktor-faktor yang berpengaruh nyata terhadap skor PPH adalah tingkat pendidikan peserta (X1) ukuran keluarga (X2) serta pengetahuan pangan dan gizi ibu rumah tangga (X3).
Kata kunci: P2L, konsumsi pangan, TKE,TKP dan skor PPH.
PENGARUH KONSENTRASI RPTT (Rizobakteri Pemacu Tumbuh Tanaman) DAN DOSIS PUPUK NPK TERHADAP PERTUMBUHAN DAN HASIL KEDELAI (Glycine max L. Merrill) VARIETAS DERING 2
Authors: Danger Crobertha Oba Doa Rathu , Komariah Ai , Romiyadi Romiyadi 
Published: June 2024

Penelitian ini bertujuan untuk mengetahui dan mempelajari interaksi RPTT dan pupuk NPK serta mencari konsentrasi dan dosis perlakuan yang memberikan pengaruh yang terbaik terhadap pertumbuhan dan hasil tanaman kedelai varietas Dering 2. Percobaan dilaksanakan di kebun percobaan Fakultas Pertanian UNWIM pada bulan Februari hingga Juni 2023, ketinggian tempat 875 mdpl dan jenis tanah Andisol.Â Percobaan ini menggunakan Rancangan Acak Kelompok (RAK) pola faktorial yang terdiri dari 2 faktor. Faktor pertama yaitu konsentrasi RPTT yang terdiri dari 4 taraf, yaitu: p0 = 0 ml L-1, p1 = 5 ml L-1, p2 = 10 ml L-1 danÂ p3 = 15 ml L-1. Faktor kedua yaitu dosis NPK yang terdiri dari 4 taraf, yaitu n0= 0 kg ha-1, n1= 5 kg ha-1, n2= 10 kg ha-1 dan n3= 15 kg ha-1. Hasil penelitian menunjukkan tidak terjadi interaksi antara konsentrasi RPTT dan dosis pupuk NPK, secara mandiri konsentrasi RPTT 15 ml L-1 berpengaruh nyata terhadap bobot 100 biji, sedangkan dosis pupuk NPK 150 kg ha-1 berpengaruh terhadap jumlah daun umur 35 HST dan dosis 450 kg ha-1 berpengaruh nyata terhadap bobot 100 biji.Kata kunci : Kedelai, Konsentrasi Rizobakteria Pemacu Tumbuh Tanaman, Dosis Pupuk NPK
Factores que influyen en el comportamiento del consumidor por la implementación del marketing digital en el sector hotelero de la ciudad de Machala.
Authors: Diaz Barrezueta Jordan Andres , Avila Rivas Vladimir Alexander , Aguilar Gálvez William Stalin 
Published: June 2024

El presente estudio se enfocó en analizar los factores que influyen en el comportamiento del consumidor por la implementación del marketing digital en el sector hotelero de la ciudad de Machala. El objetivo de la investigación fue establecer la relación existente entre las variables y el proceso de toma de decisiones de compra en los servicios ofrecidos por los hoteles de la ciudad de Machala. La investigación se llevó a cabo con la participación de una muestra de 250 individuos de dicha localidad, con edades entre los 25 y 50 años. Los datos recopilados se analizaron utilizando un modelo teórico propuesto en este estudio. Para el análisis estadístico, se utilizó la metodología de ecuaciones estructurales PLS-SEM, empleando una encuesta basada en una escala tipo Likert. Dicho modelo permitió obtener datos que demuestran el impacto positivo de cuatro variables clave (marketing digital, calidad del servicio, satisfacción y valor de marca) en el proceso de toma de decisiones de compra. En conclusión, los resultados obtenidos proporcionaran información relevante para la implementación efectiva de nuevas estrategias de marketing digital.