bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of neoadjuvant chemotherapy combined with prophylactic intraperitoneal hyperthermic chemotherapy for patients diagnosed with clinical T4 gastric cancer who underwent laparoscopic radical gastrectomy: a retrospective cohort study based on propensity score matching
Authors: Lv Chenbin , Tong Lin-Yan , Zeng Wei-Ming , Chen Qiu-Xian , Fang Shun-Yong , Sun Yu-Qin , Cai Li-Sheng 
Published: June 2024

Abstract

Background
Clinical T4 (cT4) stage gastric cancer presents with frequent postoperative recurrence and poor prognosis. This study is to evaluate the oncological efficacy of laparoscopic radical total gastrectomy combined with postoperative prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with cT4N + M0 gastric cancer who received neoadjuvant chemotherapy.
Methods
We reviewed the clinicopathological data of 174 patients with clinical T4 gastric cancer who underwent neoadjuvant chemotherapy followed by laparoscopic radical total gastrectomy between June 2017 and December 2021. Among them, 142 were included in the non-HIPEC group, and 32 in the HIPEC group. Patients in both groups were paired based on propensity score in a 2:1 ratio to assess disparities in tumor recurrence and long-term survival.
Results
After matching, there were no significant differences in the clinicopathological data between the two groups. The peritoneum (16.1%) and distant organs (10.9%) were the most frequent locations for recurrence. Prior to matching, the recurrence rates were similar at all sites for both groups. Compared with those in the non-HIPEC cohort, the recurrence rates at all sites, the lung, and the peritoneum were notably lower in the HIPEC cohort. Prior to matching, the 3-year overall survival and disease-free survival rates were similar between the two groups; following matching, the HIPEC group exhibited notably greater survival rates than did the non-HIPEC group. The disparities in survival rates between the groups became even more pronounced after conducting a stratified analysis among patients with stage III disease.
Conclusions
Neoadjuvant chemotherapy combined with prophylactic HIPEC after laparoscopic radical gastrectomy can effectively reduce the rate of peritoneal metastasis in patients with cT4N + M0 advanced gastric cancer and significantly improve the prognosis of such patients, which is of great clinical value.
New Possibilities of A Quantitative Assessment Method for the Jebsen-Taylor Hand Function Test: A Preliminary Study
Authors: Seo Na-Yun , Lee Joo-Hyun , Jung Young-Jin 
Published: June 2024

Abstract

The Jebsen–Taylor Hand Function Test (JTHFT) is a standardized and objective assessment tool for evaluating hand dysfunction in various conditions (including stroke and spinal cord injury). The JTHFT has been widely used successfully in clinical settings; however, the instrument score does not reflect mechanical movement information of the upper extremities. Therefore, we developed a software to quantitatively evaluate the JTHFT. The subject’s motion was recorded using a webcam and a deep learning-based three-dimensional motion-extraction technique. Several elements were calculated from vectors between two points. Consequently, eight factors were analyzed: distance to move beans, velocity of the hand moving beans, time to move beans, time to put beans in a spoon, time to put beans in a cup, angle of the dorsum of the hand, trajectory of the hand, and total task time. The average task time was 6.82 s (standard deviation, 0.09), which within the normal range for adults. The cross-product angle of the dorsum of the hand was confirmed to be 0.01 units, depending on how tilted the hand was. In summary, we identified new quantitative assessment tools for occupational therapy; the extracted index results allowed for quantitative evaluation of the aspect that was previously impossible to judge.
Study of the main phase and the recovery phase of ICME induced geomagnetic storms during Solar Cycle 24.
Authors: Aljehani B. , Badruddin B. 
Published: June 2024

Abstract

We study the temporal evolution and time lag characteristics of interplanetary coronal mass ejection (ICME) induced geomagnetic storm (GS) by comparing the geomagnetic storm time evolution with the time variation of four selected solar wind plasma and interplanetary magnetic field parameters, (B, V, Bz, Ey). We selected 25 events over the Solar Cycle 24 as well as we identified their characteristics during their near-Earth passage. To analyze, we evaluate the time lag of previous parameters for 25 different intensities geomagnetic storms (GS) using (Dst/SYM-H) index which have time resolutions respectively (1 hour, 1 minute). We apply a correlation analysis of the time lag of GSs with specific features of ICMEs. We apply an exponential fit to the recovery profile for the GS events associated with ICME for hourly data between the Dst index and selected interplanetary plasma and interplanetary magnetic field parameters. These findings provide useful insight of the geomagnetic storm evolution and solar-terrestrial connection.
Controlled sodium-water reaction and its application in long-duration energy storage
Authors: Tan Da-Zhi , Chen Tongtong , Fan Wenjie 
Published: June 2024

Abstract

The reaction between sodium and water is often perceived as highly exothermic, potentially leading to ignition and even explosion, creating a lasting impression that the reaction is difficult to control. However, the sodium-water reaction occurs in stages rather than instantaneously. Initially, sodium reacts with water to produce sodium hydroxide and hydrogen gas, releasing heat that converts water into steam, thus posing an explosion risk due to the generated gas. Subsequently, sodium reacts with water vapor, leading to combustion and an escalating risk of runaway temperatures. Various measures can be employed to ensure the safe reaction of sodium with water. For instance, evacuating hydrogen gas under kerosene protection ensures the safe reaction of sodium and water. Similarly, timely heat dissipation under hydrogen gas protection allows for the safe reaction of sodium and water vapor. Controllable reactions between sodium and water not only address the challenge of disposing of radioactive sodium waste but can also be applied to sodium-based long-term energy storage systems. This application helps overcome the mismatch between renewable energy development and electricity demand, supporting economic growth and decoupling carbon emissions. These advancements present new opportunities for sustainable development.
Background predation risk induces neophobia in zebrafish
Authors: Thapa Himal , Salahinejad Arash , Crane Adam L. , Ghobeishavi Ahmad , Ferrari Maud C. O. 
Published: June 2024

Abstract

Prey face a major challenge in balancing predator avoidance with other essential activities. In environments with high risk, prey may exhibit neophobia (fear of novelty) due to the increased likelihood of novel stimuli being dangerous. The zebrafish, Danio rerio, is an established model organism for many scientific studies. Although spatial and object neophobia in zebrafish have received previous attention, little is known about the role of background risk in inducing neophobia in zebrafish. Here, we present two experiments using zebrafish to explore whether background predation risk can induce fear in a novel environment and when exposed to a novel odour. Over five days, we repeatedly exposed zebrafish to either high background risk in the form of chemical alarm cues (i.e., injured conspecific cues that indicate a predator attack) or a low-risk water control stimulus. When tested in a novel spatial environment, zebrafish exposed to high predation risk displayed fear responses (reduced activity and bottom time) compared to their low-risk counterparts. Moreover, high-risk individuals exhibited fear responses toward a novel odour, unlike low-risk individuals. These results reveal that short-term repeated exposures to high risk can induce neophobia in zebrafish.
Stereotactic Radiosurgery for Brain Metastases from Human Epidermal Receptor 2 Positive Breast Cancer: An International, Multi-center Study
Authors: Pikis Stylianos , Mantziaris Georgios , Protopapa Maria , Kowalchuk Roman O. Kowalchuk , Ross Richard Blake , Rusthoven Chad G. , Tripathi Manjul , Langlois Anne-Marie Langlois , Mathieu David , Lee Cheng-chia Lee , Yang Huai-che , Peker Selcuk , Samanci Yavuz , Zhang Michael Yu , Braunstein Steve E. , Toss Salem M. , Niranjan Ajay , Wei Zhishuo , Lunsford Dade , Sheehan Jason 
Published: June 2024

Abstract

Purpose
To report patient outcomes and local tumor control rates in a cohort of patients with biopsy-proven HER-2 positive breast cancer treated with stereotactic radiosurgery (SRS) for brain metastases (BM).
Methods
This international, retrospective, multicenter study, included 195 female patients with 1706 SRS-treated BM. Radiologic and clinical outcomes after SRS were determined and prognostic factors identified.
Results
At SRS, median patient age was 55 years [interquartile range (IQR) 47.6–62.0], and 156 (80%) patients had KPS ≥ 80. The median tumor volume was 0.1 cm3 (IQR 0.1–0.5) and the median prescription dose was 16 Gy (IQR 16–18). Local tumor control (LTC) rate was 98%, 94%, 93%, 90%, and 88% at six-, 12-, 24-, 36- and 60-months post-SRS, respectively. On multivariate analysis, tumor volume (p = < 0.001) and concurrent pertuzumab (p = 0.02) improved LTC. Overall survival (OS) rates at six-, 12-, 24-, 36-, 48-, and 60-months were 90%, 69%, 46%, 27%, 22%, and 18%, respectively. Concurrent pertuzumab improved OS (p = 0.032). In this patient subgroup, GPA scores ≥ 2.5 (p = 0.038 and p = 0.003) and rare primary tumor histologies (p = 0.01) were associated with increased and decreased OS respectively. Asymptomatic adverse radiation events (ARE) occurred in 27 (14.0%) and symptomatic ARE in five (2.6%) patients. Invasive lobular carcinoma primary (p = 0.042) and concurrent pertuzumab (p < 0.001) conferred an increased risk for overall but not for symptomatic ARE.
Conclusion
SRS affords effective LTC for selected patients with BM from HER-2 positive breast cancer. Concurrent pertuzumab improved LTC and OS with however an increased risk for overall but not symptomatic ARE.
Safety and Efficacy of Exposed Endoscopic Full-thickness Resection for Colorectal Submucosal Tumors Originating from Muscularis Propria
Authors: Yalikong Ayimukedisi , Qi Zhi-peng , Ablat Kadinur , He Dongli , Lv Zhen-tao , Shi Qiang , Zhong Yun-shi 
Published: June 2024

Abstract

Objectives
Endoscopic resection of the submucosal tumors (SMTs) is a promising minimally invasive alternative surgery for the treatment of SMTs. The aim of this study was to evaluate the safety and efficacy of exposed EFTR in the treatment of colorectal SMTs through retrospective data analysis.
Methods
The patients who underwent exposed endoscopic full-thickness resection (EFTR) for colorectal SMTs in Zhongshan Hospital of Fudan University and Zhongshan-Xuhui Hospital between March 2012 and December 2022 were enrolled. The information of patients, such as basic information, medical history, preoperative and postoperative conditions, surgical conditions, postoperative complications, etc. were collected for analysis.
Results
The study enrolled 26 patients. Most of the patients were asymptomatic (76.92%) and found the colorectal SMT through physical examination. The size of the tumor was13.5(8.5,20.0) mm. And, the tumor located mostly in the rectum. During the resection, the technical success rate was 100%. The median procedural time was 46.5(29.25,63.25) min. Of the 26 cases of colorectal SMTs, 13 (50%) were determined to be GIST. As for the adverse events, 3 of the 26 patients were suffered from post-polypectomy syndrome (11.54%), one patient was suffered from postoperative bleeding (3.85%), of whom performed emergency endoscopic hemostasis; One patient (3.85) suffered from postoperative perforation and transferred to perform exploratory laparotomy to repair the defect. All patients improved after treatment, and no patient died because of the adverse events. During the follow-up time 43.5(22.5,48) months, no metastasis or recurrence was observed.
Conclusions
Exposed EFTR for colorectal SMTs originating from muscularis propria is effective with an acceptable incidence rate of adverse events and good postoperative recovery.
PCGF1 promotes the tumorigenesis of malignancies through upregulating CCDC34 in glioma
Authors: Chen Yuanbing , Xiong Jianbing , Ou Ziran , Zhao Tianhao , Li Hui , Huang Jun , Cao Wuyang 
Published: June 2024

Abstract

Introduction
Polycomb group factor 1 (PCGF1) and coiled-coil domain-containing protein 34 (CCDC34) are detected as tumorigenesis of malignancies. However, the function and the prognostic value of PCGF1 and CCDC34 in glioma still remain unclear. Methods Analyzed the data of RNA-seq with the knockdown of PCGF1 in glioma cell lines from GEO database. Explored the correlation of gene expression between PCGF1 and CCDC34 in TCGA, CGGA, and GEO databases. Moreover, RT-qPCR was used to measure the expression of PCGF1 and CCDC34 in glioma specimens. Additionally, Kaplan-Meier analyses were conducted to explore the prognostic value of CCDC34 in glioma. Further, CCDC34 knockdown and PCGF1 overexpressed cell lines were constructed to investigate the effect of CCDC34 and PCGF1 on glioma. The cell growth and colony formation were performed.
Results
The CCDC34 was significantly downregulated in glioma cell lines with the knockdown of PCGF1 compared to the control group. The expression level of CCDC34 were positive correlation with the grade of WHO in glioma. The outcome of the patients were strongly associated with the expression of CCDC34. The knockdown of CCDC34 was shown to inhibit cell proliferation and colony formation. And a rescue experiment revealed PCGF1 promotes the proliferation of glioma dependent on CCDC34. The analysis of GSEA suggests that the expression of PCGF and CCDC34 were positively correlated with the hypoxia, coagulation, and EMT signaling pathway.
Conclusion
Our data demonstrated that PCGF1 promotes the proliferation of glioma dependent on CCDC34, which indicated that CCDC34 could be used as a novel potential prognostic marker.
Correlation between three pro-nuclei (3PN) incidence and further embryo multinucleation at the two-cell stage (MN2) during IVF: A time-lapse study
Authors: Li Mingzhao , Xue Xia , Shi Juanzi 
Published: June 2024

Abstract

The incidence of ≥ 3PN zygotes and blastomere multinucleation was found to be elevated in the presence of increased E2 levels and a greater number of retrieved oocytes. This implies a potential link between the incidence of MN2 and a higher proportion of ≥ 3PN zygotes. We aimed to investigate the effect of high proportion of 3PN zygotes on MN2 incidence during IVF by using time-lapse monitoring (TLM). This study included 1195 patients with TLM from January 2020 to December 2022. The TLM patients were categorized into three groups: Group 1 comprised patients with no ≥ 3PN zygotes (n = 422), Group 2 included those with 0–25% ≥3PN zygotes (n = 617), and Group 3 consisted of patients with more than 25% ≥3PN zygotes (n = 156).The MN2 rate, types of MN2 and clinical outcomes were compared among the three groups. Our data indicated that the live birth rate was significantly higher in the group 2 than that in the group 3 (65.32 versus 56.41%; p = 0.039). The group 1 and 2 showed significantly lower MN2 rates than group 3 (18.33 and 19.45% versus 25.62%; p < 0.001). The MN2 embryos exhibited similar rates of high-quality embryos (42.27 versus 43.50 versus 40.67%; p = 0.401) and available embryos (84.96 versus 84.04 versus 83.21%; p = 0.460) rates among three groups. There were no significant differences in the proportion of MN2 with different types among the three groups (p > 0.05). There were no significant differences in the blastocyst formation rates for embryos with different type of MN2 among the three groups (p > 0.05). A high frequency of ≥ 3PN zygotes incidence might lead to a decrease in the rate of live births, and the occurrence of MN2 events could be predicted based on the ≥ 3PN zygotes incidence.
Validation of neuron activation patterns for deep learning models in oculomics
Authors: An Songyang , Squirrell David 
Published: June 2024

Abstract

Deep learning and artificial neural networks have been extensively applied to the automated diagnosis of retinal diseases from fundus images. Recent advancements have also led researchers to leverage deep learning to examine the connections between the retina and systemic health in a discipline termed oculomics. However, as oculomics models likely combine multiple retinal features to arrive at their conclusions, traditional methods in model interpretation, such as attribution saliency maps, often provide uncompelling and open-ended explanations that are prone to interpretation bias, highlighting a need for the examination of alternative strategies that can quantitatively describe model behavior. One potential solution is neuron activation patterns, which were previously applied to real-time fault diagnosis of deep learning models. In this study, we proposed a novel and experimental framework of neuron activation pattern synthesis leveraging image similarity metrics, with the outcome being a continuous, metric-based descriptor of underlying model behavior. We applied our approach in examining a model predicting systolic blood pressure from fundus images trained on the United Kingdom Biobank dataset. Our results show that the metric-based descriptor was meaningfully related to cardiovascular risk, a real-life outcome that can be expected to be related to blood pressure-related biomarkers identified from a fundus image. Furthermore, it was also able to uncover two biologically distinct and statistically significant groups among participants who were assigned the same predicted outcome and whose distinctness would otherwise be imperceivable without the insights generated by our approach. These results demonstrate the feasibility of this prototypical approach in neuron activation pattern synthesis for oculomics models. Further work is now required to validate these results on external datasets.
Is Coagulation-related indicators associated with COVID19-related mortality? A evidence obtained from 663 Chinese patients with COVID-19 infection in a retrospective cohort study
Authors: Fu Wei , Chen Chi , Chen Xin-Lin , Wu Xia-Li , Wang Kun , Zuo Peiyuan , Liu Yuwei , Zhang Meng , Zhao Xiaofang , Xie Songpu , Zhang Hao , Liu Chengyun 
Published: June 2024

Abstract

Background
Several studies have found that coagulation-related markers are correlated with a poor prognosis in patients were diagnosed COVID-19 infection. However, the findings of these studies are constrained by methodology and data analysis. Furthermore, there would be little evidence to report trends in coagulation-related indicators over time all through the disease's progression.
Methods
From January 7, 2020 to February 28, 2020, we collected 663 participants in a Chinese hospital in a non-selective and consecutive manner. The association between baseline coagulation-related indicators and death was investigated using a standardized and two-piecewise Cox regression model. The GAMM (generalized additive mixed model) was used to examine the time-varying trend of indicators in non-survivors and survivors.
Results
Of the six coagulation-related indicators, basal-Log2D-dimer (D-D) was independently positively correlated with the risk of death .The area under the ROC (receiver operating characteristic curve) curve is 0.7937 and the optimum cut-off value is 0.4650mg/L. In the GAMM model, we found that thrombin time (TT ) (interaction coefficient 0.0071; 95%CI 0.0034to 0.0108) and activated partial thromboplastin time (aPTT) (interaction coefficient 0.0217; 95%CI 0.0160 to 0.0273) of non-survivors have been increasing progressively over time during the entire disease course compared with no fluctuations among survivors. An inverse U-shaped time-vary trend was observed in D-D, prothrombin time (PT) and international normalized ratio (INR) among non-survivors, while a steady trend was found among survivors.
Conclusion
Baseline D-D were independently positively correlated with the risk of death and have the potential to be used for risk assessment early on.
Genomic variation in Plasmodium relictum (lineage SGS1) and its implications for avian malaria infection outcomes: insights from experimental infections and genome-wide analysis
Authors: Kalbskopf Victor , Aželytė Juste , Palinauskas Vaidas , Olof Hellgren 
Published: June 2024

Abstract

Background
The globally transmitted avian malaria parasite Plasmodium relictum (lineage SGS1) has been found to infect hundreds of different bird species with differences in infection outcomes ranging from more or less latent to potential mortal. However, to date basic knowledge about the links between genetic differentiation and variation in infection outcome within this single Malaria species is lacking.
Method
In this study, we used two different isolates of SGS1, obtained in the wild from two different host species, to investigate differences their development in the blood and virulence to the experimentally infected canaries. Simultaneously, 258kb of the parasite genome was screened for genetic differences using parasite mRNA and compared between experimental groups.
Result
The two isolates showed differences in development and caused mortality as well as in effects on the blood parameters of their hosts. Although previous studies using single genes have shown very limited within lineage genetic diversity in the European population of SGS1, we found, across 322 genes, 226 SNPs, which separated the two experimental groups with a total of 23 SNPs that were fixed in either of the experimental groups. Moreover, genetic variation was found within each experimental group, hinting that each avian malaria infection harbors standing genetic variation that might be selected during each individual infection episode.
Conclusion
These results highlight extensive genetic variation within the SGS1 population that is transferred into individual infections, thus adding to the complexity of the infection dynamics seen in these host-parasite interactions. Simultaneously, the results open up the possibility of understanding how genetic variation within the parasite populations is linked to the commonly observed differences in infection outcomes, both in experimental settings and in the wild.