bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Paleomagnetic Results From the Late Mesoproterozoic Luanshigou Formation, Shennongjia Group in South China and Their Implications for the Pre‐Grenvillian Connections Between South China Blocks and Southwestern Laurentia
Authors: Liu Yixuan , Zhang Shihong , Li Haiyan , Yang Kunkun , Zhang Nana , Li Huaikun , Wang Zhixian , Yang Tianshui , Wu Huaichun 
Published: June 2024

AbstractThe identification of the Grenvillian‐age ophiolite suites in the Yangtze block in recent years suggested that the northern Yangtze subblock (NYB) and the southern Yangtze subblock (SYB) were once separated by an ocean in late Mesoproterozoic. Although some paleogeographic models advocated the Pre‐Grenvillian connections between the south China blocks and Laurentia, none of them has been paleomagnetically tested. Here we report the new paleomagnetic results obtained from the ∼1,270 Ma purplish‐red muddy dolomite beds of the Luanshigou Formation, Shennongjia Group, NYB, providing new constraints for reconstructing the paleogeographic positions of the south China blocks in late Mesoproterozoic. A total of 447 samples underwent stepwise thermal demagnetization. Two components were identified. The low‐temperature component is interpreted as the recent viscous remnant magnetization. The high‐temperature component was obtained from 64 samples below 580°C and from 177 samples below 690°C, directed northeast‐up or southwest‐down, antipodally, positioning the paleomagnetic pole at 18.5°S, 74.4°E (dm/dp = 2.5/1.6°). Rock magnetic results demonstrate that the magnetic carriers in purplish‐red dolomite and pale‐pink dolomite are predominated by hematite and magnetite, respectively. The data quality is supported by an inverse baked contact test, a B‐class reversal test, and the paleomagnetic pole is distinct from any younger poles of the region. Based on the paleomagnetic results, aided by geological evidence, we propose a reconstruction in which the NYB was juxtaposed to southwestern Laurentia in the late Mesoproterozoic and suggest that the late Mesoproterozoic Miaowan‐Shimian ophiolite zone in the Yangtze block was likely an extension of the Grenville belt of Laurentia.
Global Optimization of Soil Texture Maps From Satellite‐Observed Soil Moisture Drydowns and Its Implementation in Noah‐MP Land Surface Model
Authors: He Qing , Lu Hui , Yang Kun , Oki Taikan , Zhou Jianhong , Zhao Long , Yao Panpan , He Jie , Wang Aihui , Xu Yawei 
Published: June 2024

AbstractSoil moisture (SM) plays an important role in regulating regional weather and climate. However, the simulations of SM in current land surface models (LSMs) contain large biases and model spreads. One primary reason contributing to such model biases could be the misrepresentation of soil texture in LSMs, since current available large‐scale soil texture data are often generated from extrapolation algorithm based on a scarce number of in‐situ geological measurements. Fortunately, recent advancements in satellite technology provide a unique opportunity to constrain the soil texture data sets by introducing observed information at large spatial scales. Here, two major soil texture baseline data sets (Global Soil Data sets for Earth system science, GSDE and Harmonized World Soil Data from Food and Agriculture Organization, HWSD) are optimized with satellite‐estimated soil hydraulic parameters. The optimized soil maps show increased (decreased) sand (clay) content over arid regions. The soil organic carbon (SOC) content increases globally especially over regions with dense vegetation cover. The optimized soil texture data sets are then used to run simulations in one example LSM, that is, Noah LSM with Multiple Parameters. Results show that the simulated SM with satellite‐optimized soil texture maps is improved at both grid and in‐situ scales. Intercase comparison analyses show the SM improvement differs between simulations using different soil maps and soil hydraulic schemes. Our results highlight the importance of incorporating observation‐oriented calibration on soil texture in current LSMs. This study also joins the call for a better soil profile representation in the next generation of Earth System Models (ESMs).
Disk Images of Neutral Temperature From the Global‐Scale Observations of the Limb and Disk (GOLD) Mission
Authors: Evans J. S. , Lumpe J. D. , Eastes R. W. , Correira J. , Aryal S. , Laskar F. , Veibell V. , Krywonos A. , Plummer T. , McClintock W. E. 
Published: June 2024

AbstractObservations of far‐ultraviolet (FUV) dayglow by the Global‐scale Observations of Limb and Disk (GOLD) mission provide an opportunity for quantifying the global‐scale response of the thermosphere to solar extreme‐ultraviolet variability and geomagnetic activity. Relative temperature changes can be measured by monitoring changes in the rotational structure observed in molecular nitrogen Lyman‐Birge‐Hopfield (LBH) band emissions. We present a new technique for deriving effective neutral temperatures from GOLD FUV observations using optimal estimation fits to spectra containing LBH band emissions. We provide an overview of the theoretical basis for the GOLD Level 2 TDISK algorithm. Effects on derived effective neutral temperatures from instrument artifacts and particle background are reviewed. We also discuss GOLD Level 1C DAY and Level 2 TDISK data products and present representative examples of each. We show that effective neutral temperatures vary with local time, exhibit a strong dependence on season and solar zenith angle, and correlate strongly with geomagnetic and solar activity. Finally, we present results from a preliminary data product validation that show good agreement with coincident GOLD exospheric temperatures and predictions from a global reference atmospheric model.
A Review of the Migration of Hydrogen From the Planetary to Basin Scale
Authors: Lodhia Bhavik Harish , Peeters Luk , Frery Emanuelle 
Published: June 2024

AbstractThe occurrence of natural hydrogen and its sources have been reviewed extensively in the literature over the last few years, with current research across both academia and industry focused on assessing the feasibility of utilizing natural hydrogen as an energy resource. However, gaps remain in our understanding of the mechanisms responsible for the large‐scale transport of hydrogen and migration through the deep and shallow Earth and within geological basins. Due to the unique chemical and physical properties of hydrogen, the timescales of migration within different areas of Earth vary from billions to thousands of years. Within the shallow Earth, diffusive and advective transport mechanisms are dependent on a wide range of parameters including geological structure, microbial activity, and subsurface environmental factors. Hydrogen migration through different media may occur from geological timescales to days and hours. We review the nature and timescale of hydrogen migration from the planetary to basin‐scale, and within both the deep and shallow Earth. We explore the role of planetary accretion in setting the hydrogen budget of the lower mantle, discuss conceptual frameworks for primordial or deep mantle hydrogen migration to the Earth's surface and evaluate the literature on the lower mantle's potential role in setting the hydrogen budget of rocks delivered from the deep Earth. We also review the mechanisms and timescales of hydrogen within diffusive and advective, fossil versus generative and within biologically moderated systems within the shallow Earth. Finally, we summarize timescales of hydrogen migration through different regions within sedimentary basins.
Magnetic Domain States and Critical Sizes in the Titanomagnetite Series
Authors: Cych Brendan , Paterson Greig A. , Nagy Lesleis , Williams Wyn , Moskowitz Bruce 
Published: June 2024

AbstractThe minerals carrying the magnetic remanence in geological samples are commonly a solid solution series of iron‐titanium spinels known as titanomagnetites. Despite the range of possible compositions within this series, micromagnetic studies that characterize the magnetic domain structures present in these minerals have typically focused on magnetite. No studies systematically comparing the domain‐states present in titanomagnetites have been undertaken since the discovery of the single vortex (SV) structure and the advent of modern micromagnetism. The magnetic properties of the titanomagnetite series are known to vary strongly with composition, which may influence the domain states present in these minerals, and therefore the magnetic stability of the samples bearing them. We present results from micromagnetic simulations of titanomagnetite ellipsoids of varying shape and composition to find the size ranges of the single domain (SD) and SV structures. These size ranges overlap, allowing for regions where the SD and SV structures are both available. These regions are of interest as they may lead to magnetic instability and “partial thermal remanent magnetization (pTRM) tails” in paleointensity experiments. We find that although this SD + SV zone occupies a narrow range of sizes for equidimensional magnetite, it is widest for intermediate (TM30‐40) titanomagnetite compositions, and increases for both oblate and prolate particles, with some compositions and sizes having an SD + SV zone up to 100s of nm wide. Our results help to explain the prevalence of pTRM tail‐like behavior in paleointensity experiments. They also highlight regions of particles with unusual domain states to target for further investigation into the definitive mechanism behind paleointensity failure.
Influences of Solar Wind Parameters on Energetic Electron Fluxes at Geosynchronous Orbit Revealed by the Deep SHAP Method
Authors: Wang Jianhang , Xiang Zheng , Ni Binbin , Guo Deyu , Liu Yangxizi , Dong Junhu , Hu Jingle , Guo Haozhi 
Published: June 2024

AbstractSolar wind is an intermediary in energy transfer from the Sun into the Earth's magnetosphere, and is considered as a decisive driver of energetic electron dynamics at the geosynchronous orbit (GEO). Based on machine learning technology, several models driven by solar wind parameters have been established to predict GEO electron fluxes. However, the relative contributions of different solar wind parameters on GEO electron fluxes are still unclear. Recently, a feature attribution method, Deep SHapley Additive exPlanations (Deep SHAP) is proposed to open black boxes of machine learning models. In this study, we use the Deep SHAP method to quantify contributions of different solar wind parameters with an artificial neural network (ANN) model. Backpropagating the prediction results of this ANN model from 2011 to 2020, SHAP values for four solar wind parameters (interplanetary magnetic field (IMF) BZ, solar wind speed, solar wind dynamic pressure, and proton density) are calculated and comprehensively analyzed. The results suggest that solar wind speed with a lag of 1 day is the most important driver. We further investigate relative roles of different parameters in three specific electron fluxes variation events (corresponding to electron fluxes reaching a local maximum, a local minimum, and unchanged, respectively). The results suggest that high solar wind speed and southward IMF BZ (high dynamic pressures) facilitate increases (decreases) of electron fluxes. These findings help reveal the underlying physical mechanisms of GEO electron dynamics and help develop more accurate prediction models for GEO electron fluxes.
Inverted Alu repeats: friends or foes in the human transcriptome
Authors: Lee Keonyong , Ku Jayoung , Ku Doyeong , Kim Yoosik 
Published: June 2024

AbstractAlu elements are highly abundant primate-specific short interspersed nuclear elements that account for ~10% of the human genome. Due to their preferential location in gene-rich regions, especially in introns and 3′ UTRs, Alu elements can exert regulatory effects on the expression of both host and neighboring genes. When two Alu elements with inverse orientations are positioned in close proximity, their transcription results in the generation of distinct double-stranded RNAs (dsRNAs), known as inverted Alu repeats (IRAlus). IRAlus are key immunogenic self-dsRNAs and post-transcriptional cis-regulatory elements that play a role in circular RNA biogenesis, as well as RNA transport and stability. Recently, IRAlus dsRNAs have emerged as regulators of transcription and activators of Z-DNA-binding proteins. The formation and activity of IRAlus can be modulated through RNA editing and interactions with RNA-binding proteins, and misregulation of IRAlus has been implicated in several immune-associated disorders. In this review, we summarize the emerging functions of IRAlus dsRNAs, the regulatory mechanisms governing IRAlus activity, and their relevance in the pathogenesis of human diseases.
Stromal cells engineered to express T cell factors induce robust CLL cell proliferation in vitro and in PDX co-transplantations allowing the identification of RAF inhibitors as anti-proliferative drugs
Authors: Hoferkova Eva , Seda Vaclav , Kadakova Sona , Verner Jan , Loja Tomas , Matulova Kvetoslava , Skuhrova Francova Hana , Ondrouskova Eva , Filip Daniel , Blavet Nicolas , Boudny Miroslav , Mladonicka Pavlasova Gabriela , Vecera Josef , Ondrisova Laura , Pavelkova Petra , Hlavac Krystof , Kostalova Lenka , Michaelou Androniki , Pospisilova Sarka , Dorazilova Jana , Chochola Vaclav , Jaros Josef , Doubek Michael , Jarosova Marie , Hampl Ales , Vojtova Lucy , Kren Leos , Mayer Jiri , Mraz Marek 
Published: June 2024

AbstractSeveral in vitro models have been developed to mimic chronic lymphocytic leukemia (CLL) proliferation in immune niches; however, they typically do not induce robust proliferation. We prepared a novel model based on mimicking T-cell signals in vitro and in patient-derived xenografts (PDXs). Six supportive cell lines were prepared by engineering HS5 stromal cells with stable expression of human CD40L, IL4, IL21, and their combinations. Co-culture with HS5 expressing CD40L and IL4 in combination led to mild CLL cell proliferation (median 7% at day 7), while the HS5 expressing CD40L, IL4, and IL21 led to unprecedented proliferation rate (median 44%). The co-cultures mimicked the gene expression fingerprint of lymph node CLL cells (MYC, NFκB, and E2F signatures) and revealed novel vulnerabilities in CLL-T-cell-induced proliferation. Drug testing in co-cultures revealed for the first time that pan-RAF inhibitors fully block CLL proliferation. The co-culture model can be downscaled to five microliter volume for large drug screening purposes or upscaled to CLL PDXs by HS5-CD40L-IL4 ± IL21 co-transplantation. Co-transplanting NSG mice with purified CLL cells and HS5-CD40L-IL4 or HS5-CD40L-IL4-IL21 cells on collagen-based scaffold led to 47% or 82% engraftment efficacy, respectively, with ~20% of PDXs being clonally related to CLL, potentially overcoming the need to co-transplant autologous T-cells in PDXs.
A near-infrared spectroscopy dataset of coal and coal-measure rock under diverse conditions
Authors: Lv Yuanbo , Wang Shibo , Yang En , Ge Shirong 
Published: June 2024

AbstractThe identification technology for coal and coal-measure rock is required across multiple stages of coal exploration, mining, separation, and tailings management. However, the construction of identification models necessitates substantial data support. To this end, we have established a near-infrared spectral dataset for coal and coal-measure rock, which includes the reflectance spectra of 24 different types of coal and coal-measure rock. For each type of sample, 11 sub-samples of different granularities were created, and reflectance spectra were collected from sub-samples at five different detection azimuths, 18 different detection zeniths, and under eight different light source zenith conditions. The quality and usability of the dataset were verified using quantitative regression and classification machine learning algorithms. Primarily, this dataset is used to train artificial intelligence-based models for identifying coal and coal-measure rock. Still, it can also be utilized for regression studies using the industrial analysis results contained within the dataset.
Intracortical mechanisms of single pulse electrical stimulation (SPES) evoked excitations and inhibitions in humans
Authors: Hajnal Boglárka , Szabó Johanna Petra , Tóth Emília , Keller Corey J. , Wittner Lucia , Mehta Ashesh D. , Erőss Loránd , Ulbert István , Fabó Dániel , Entz László 
Published: June 2024

AbstractCortico-cortical evoked potentials (CCEPs) elicited by single-pulse electric stimulation (SPES) are widely used to assess effective connectivity between cortical areas and are also implemented in the presurgical evaluation of epileptic patients. Nevertheless, the cortical generators underlying the various components of CCEPs in humans have not yet been elucidated. Our aim was to describe the laminar pattern arising under SPES evoked CCEP components (P1, N1, P2, N2, P3) and to evaluate the similarities between N2 and the downstate of sleep slow waves. We used intra-cortical laminar microelectrodes (LMEs) to record CCEPs evoked by 10 mA bipolar 0.5 Hz electric pulses in seven patients with medically intractable epilepsy implanted with subdural grids. Based on the laminar profile of CCEPs, the latency of components is not layer-dependent, however their rate of appearance varies across cortical depth and stimulation distance, while the seizure onset zone does not seem to affect the emergence of components. Early neural excitation primarily engages middle and deep layers, propagating to the superficial layers, followed by mainly superficial inhibition, concluding in a sleep slow wave-like inhibition and excitation sequence.
Rapid detection of FadA in Fusobacterium nucleatum using the quantitative LAMP colorimetric phenol red method in stool samples from colorectal cancer patients
Authors: Zuraik Abdulrahman A. , Daboul Yaman , Awama M. Ayman , Yazigi Haitham , Kayasseh Moh’d Azzam , Georges Michael 
Published: June 2024

AbstractThe study aimed to develop a quantitative colorimetric loop-mediated isothermal amplification technique using the phenol red indicator (QLAMP-PhR) for detecting Fusobacterium nucleatum (Fn) levels in colorectal cancer (CRC) patients and healthy individuals. QLAMP-PhR assays were conducted on 251 stool samples specific for the Fn FadA gene. Six primers were synthesized and utilized with master mix reagents, and a phenol red indicator was employed to enhance the QLAMP-PhR technique. A standard quantitative analysis curve was generated using a logarithmic function (absorbance vs. concentration) by serially diluting the copy number of genomic DNA templates (Fn ATCC25586). The CRC group exhibited a significantly higher abundance of Fn compared to the healthy control group (P < 0.001). These findings suggest that the QLAMP-PhR technique effectively identifies Fn specifically by its gene for the key virulence factor FadA. Additionally, ideas for developing a real-time QLAMP-PhR test were presented. Compared to the traditional polymerase chain reaction (PCR) technique, QLAMP-PhR offers several advantages including rapidity, simplicity, specificity, sensitivity, and cost-effectiveness method that can quantitatively screen for Fn presence in normal populations. The QLAMP-PhR method represents a sensitive and specific amplification assay for the rapid detection of the Fn pathogen. To the best of our knowledge, this study is the first to report the application of QLAMP-PhR for detecting FadA in Fn.
Design and fabrication of porous three‐dimensional Ag-doped reduced graphene oxide (3D Ag@rGO) composite for interfacial solar desalination
Authors: Bezza Fisseha A. , Iwarere Samuel A. , Brink Hendrik G. , Chirwa Evans M. N. 
Published: June 2024

AbstractSolar-driven interfacial desalination technology has shown great promise in tackling the urgent global water scarcity crisis due to its ability to localize heat and its high solar-to-thermal energy conversion efficiency. For the realization of sustainable saline water desalination, the exploration of novel photothermal materials with higher water vapor generation and photothermal conversion efficiency is indispensable. In the current study, a novel 3D interconnected monolithic Ag-doped rGO network was synthesized for efficient photothermal application. The Ultraviolet–Visible-Near Infrared (UV–Vis-NIR) and FTIR analyses demonstrated that the controlled hydrothermal reduction of GO enabled the restoration of the conjugated sp2 bonded carbon network and the subsequent electrical and thermal conductivity through a significant reduction of oxygen-containing functional groups while maintaining the hydrophilicity of the composite photothermal material. In the solar simulated interfacial desalination study conducted using 3.5 wt.% saline water, the average surface temperatures of the 3D material increased from 27.1 to 54.7 °C in an hour, achieving an average net dark-excluded evaporation rate of 1.40 kg m−2 h−1 and a photothermal conversion efficiency of ~ 97.54% under 1 sun solar irradiance. In the outdoor real-world application test carried out, the surface temperature of the 3D solar evaporator reached up to 60 °C and achieved a net water evaporation rate of 1.50 kg m−2 h−1 under actual solar irradiation. The 3D interwoven porous hierarchical evaporator displayed no salt precipitation over the 54-h period monitored, demonstrating the promising salt rejection and real-world application potential for efficient desalination of saline water.
Probing intracellular potassium dynamics in neurons with the genetically encoded sensor lc-LysM GEPII 1.0 in vitro and in vivo
Authors: Groschup Bernhard , Calandra Gian Marco , Raitmayr Constanze , Shrouder Joshua , Llovera Gemma , Zaki Asal Ghaffari , Burgstaller Sandra , Bischof Helmut , Eroglu Emrah , Liesz Arthur , Malli Roland , Filser Severin , Plesnila Nikolaus 
Published: June 2024

AbstractNeuronal activity is accompanied by a net outflow of potassium ions (K+) from the intra- to the extracellular space. While extracellular [K+] changes during neuronal activity are well characterized, intracellular dynamics have been less well investigated due to lack of respective probes. In the current study we characterized the FRET-based K+ biosensor lc-LysM GEPII 1.0 for its capacity to measure intracellular [K+] changes in primary cultured neurons and in mouse cortical neurons in vivo. We found that lc-LysM GEPII 1.0 can resolve neuronal [K+] decreases in vitro during seizure-like and intense optogenetically evoked activity. [K+] changes during single action potentials could not be recorded. We confirmed these findings in vivo by expressing lc-LysM GEPII 1.0 in mouse cortical neurons and performing 2-photon fluorescence lifetime imaging. We observed an increase in the fluorescence lifetime of lc-LysM GEPII 1.0 during periinfarct depolarizations, which indicates a decrease in intracellular neuronal [K+]. Our findings suggest that lc-LysM GEPII 1.0 can be used to measure large changes in [K+] in neurons in vitro and in vivo but requires optimization to resolve smaller changes as observed during single action potentials.