bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunomodulatory Synthetic Glycocluster Molecule Prevents Melanoma Growth In Vivo
Authors: Honkanen Meija , Narvi Elli , Ojala Veera K , Jokilammi Anne , Rantakari Pia , Kronqvist Pauliina , Kähäri Veli‐Matti , Veräjänkorva Esko , Kurppa Kari J. , Rahkila Jani , Ekambaram Ramesh , Savolainen Johannes , Leino Reko , Elenius Klaus 
Published: June 2024

AbstractTriacedimannose (TADM) is a synthetic trivalent acetylated glycocluster and a transmembrane macrophage activator independent of the mannose receptor. TADM induces Th1‐type immune responses and suppresses Th2‐type cytokines in acute and chronic allergic inflammation models in vivo. We, therefore, wanted to test whether TADM could also facilitate anti‐tumour tissue responses similar to what has been observed for the immune checkpoint inhibitors, such as anti‐PD‐1 and anti‐CTLA‐4. A syngeneic mouse melanoma model was selected since metastatic melanoma has been successfully targeted by checkpoint inhibitors in the clinic. TADM inhibited the growth of B16 mouse melanoma tumours at levels comparable to an anti‐PD‐1 antibody. TADM‐treated tumours encompassed significantly more apoptotic cells as measured by TUNEL staining, and interferon‐gamma (IFN‐γ) expression was increased in the spleens of TADM‐treated mice compared to untreated controls. TADM‐treated mice also demonstrated increased Ly6 C low monocytes and neutrophils in the spleens. However, TADM‐treated tumours showed no discernible differences in infiltrating immune cells. TADM can alone suppress the growth of melanoma tumours. TADM likely activates M1 type macrophages, type N1 neutrophils, and CD8+ and Th1 T cells, suppressing the type 2 immune response milieu of melanoma tumour with a strong type 1 immune response.
How to Break the Activity‐Stability Conundrum in Oxygen Evolution Electrocatalysis: Mechanistic Insights
Authors: Binninger Tobias , Moss Genevieve C. , Rajan Ziba S. H. S. , Mohamed Rhiyaad , Eikerling Michael H. 
Published: June 2024

AbstractTechnically viable electrocatalysts for the oxygen evolution reaction (OER) must be both active and stable under the harsh conditions at an electrolyser anode. While numerous highly active metal‐oxide catalysts have been identified, only very few are sufficiently stable, with iridium oxides being the most prominent. In this perspective, we draw insights from OER mechanisms to circumvent the activity‐stability conundrum generally plaguing the development of OER catalysts. In the commonly considered OER mechanisms, one or several metal‐oxygen (M−O) bonds are required to be broken along the OER pathway, providing a mechanistic link between the OER and oxide decomposition. However, a recently discovered mechanism on crystalline iridium dioxide provides a new OER pathway without M−O bond breakages, thus enabling the combination of sufficient activity and stability.
Broaching spiritual and religious issues in assessment in counseling: A model for counselor preparation and practice
Authors: Stewart‐Sicking Joseph A. 
Published: June 2024

AbstractAssessing clients’ religious and spiritual resources is a fundamental multicultural competence. Building on models for broaching race in counseling, this article argues that models of competence in assessing spirituality and religion must include a critical lens and a transference lens alongside insights from the psychology of spirituality and religion.
Application of ZnS:Ni Loaded on Sponge‐Activated Carbon as an Efficient Adsorbent for Dye Removal
Authors: Khodadoust Saeid , Zeraatpisheh Fatemeh 
Published: June 2024

AbstractIn the present work, a ZnS:Ni loaded on sponge‐activated carbon (SAC) was synthesized and applied as an effective adsorbent to remove bromophenol blue (BPB) dye from aqueous solutions. Various techniques such as Fourier‐transform infrared, X‐ray diffraction, transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), and Brunauer‐Emmett‐Teller (BET) were used to characterize ZnS:Ni–SAC. The effective parameters such as BPB concentration, amount of ZnS:Ni–SAC, ultrasonic time, and pH of the aqueous solution were investigated and optimized by response surface methodology. To investigate the accuracy and reliability of the proposed method, the analysis of variance was used based on p‐values and F‐test. The optimal values of the parameters were obtained using the desirability function, and they were as follows: 15 mg L−1 BPB concentration, 20 min sonication time, 18 mg of ZnS:Ni–SAC, and pH = 7. To evaluate the adsorption mechanism and calculation of maximum adsorption capacity, different adsorption isotherms were studied, and according to the obtained results, the Langmuir isotherm model showed the highest compatibility due to its higher R2 (0.997). Also, the proposed adsorbent represented good adsorption capacity (125 mg g−1). Moreover, kinetic studies proved the applicability of the pseudo‐second‐order model (R2 = 0.986) compared to other models. The achieved results confirmed the applicability of ZnS:Ni–SAC as a versatile adsorbent for the removal of BPB.
Valorization of Sugarcane Leaf to Binderless Fiberboards by Hot‐Pressing Process and Polyurethane Coating
Authors: Sutaro Watchara , Sarattawipak Jirapat , Phuengklay Tanakorn , Kupasittirat Pasakorn , Prommachan Sutipol , Intharapat Punyanich , Phinichka Natthapong , Boonsombuti Akarin , Phalakornkule Chantaraporn 
Published: June 2024

AbstractSugarcane (Saccharum officinarum L.) leaf is an abundant waste from agriculture. In this study, we prepared binderless fiberboards from sugarcane leaf with <3 % moisture (w/w) and <1 mm in size by hot‐pressing temperature in the 210–240 °C range, followed by surface coating with polyurethane. The effect of hot‐pressing temperature on the modulus of elasticity (MOE), modulus of rupture (MOR), internal bonding (IB) strength, and thickness swelling of the binderless sugarcane leaves was investigated. An optimal pressing condition for preparing the binderless sugarcane leaf fiberboards was 230 °C for pressing temperature, 5 MPa for pressing pressure, and 600 s for pressing time, giving 1200 kg m−3 for board density, MOE of 657.1 MPa, MOR of 7.04 MPa, and IB strength of 0.277 MPa. The thickness swelling of the coated samples was almost completely eliminated by the surface coating.
A Schottky/Z‐Scheme Hybrid for Augmented Photocatalytic H2 and H2O2 Production
Authors: Acharya Lopamudra , Biswal Lijarani , Mishra Bhagyashree Priyadarshini , Das Sarmistha , Dash Srabani , Parida Kulamani 
Published: June 2024

AbstractThe prodigious employment of fossil fuels to conquer the global energy demand is becoming a dreadful threat to the human society. This predicament is appealing for a potent photocatalyst that can generate alternate energy sources via solar to chemical energy conversion. With this interest, we have fabricated a ternary heterostructure of Ti3C2 nanosheet modified g‐C3N4/Bi2O3 (MCNRBO) Z‐scheme photocatalyst through self‐assembly process. The morphological analysis clearly evidenced the close interfacial interaction between g‐C3N4 nanorod, Bi2O3 and Ti3C2 nanosheets. The oxygen vacancy created on Bi2O3 surface, as suggested by XPS and EPR analysis, supported the Z‐scheme heterojunction formation between g‐C3N4 nanorod and Bi2O3 nanosheets. The collaborative effect of Z‐scheme and Schottky junction significantly reduced charge transfer resistance promoting separation efficiency of excitons as indicated from PL and EIS analysis. The potential of MCNRBO towards photocatalytic application was investigated by H2O2 and H2 evolution reaction. A superior photocatalytic H2O2 and H2 production rate for MCNRBO is observed, which are respectively around 5 and 18 folds higher as compared to pristine CNR nanorod. The present work encourages for the development of a noble, eco‐benign and immensely efficient dual heterojunction based photocatalyst, which can acts as saviour of human society from energy crisis.
Bridging Dehydrogenation and Hydrogenation in Heterogeneous Catalysis: A Demonstration of a Unified Catalytic Approach
Authors: Jangir Jyothi , Jagirdar Balaji R. 
Published: June 2024

AbstractIn the pursuit of enhancing the applications of hydrogen as an energy carrier, this research delved into the utilization of a singular hybrid catalyst capable of performing both dehydrogenation and hydrogenation processes for Liquid Organic Hydrogen Carriers (LOHCs). This study presents the synthesis and characterization of a hybrid catalyst, combining an organometallic pincer complex with Pd−Ru heterostructures supported on γ‐alumina. Unlike conventional transition and noble metal nanoparticles, the use of a pincer complex offers exceptional thermal stability due to its aryl backbone, which is advantageous for various endothermic dehydrogenation reactions of hydrocarbons in LOHCs. This pioneering hybrid catalyst is a novel approach, demonstrating a proof of concept. In this study, we utilized the hybrid catalyst to investigate the dehydrogenation and hydrogenation of a lower enthalpic system, specifically the cyclooctane−cyclooctene system. The dehydrogenation of cyclooctane was conducted at 443 K using tertiary butyl ethylene as a sacrificial hydrogen acceptor, while the hydrogenation of cyclooctene reaction catalyzed by Pd−Ru nanostructures occurred at 298 K and 1 atm H2. The results showed successful tandem dehydrogenation‐hydrogenation reactions. However, challenges were noted in terms of catalytic activity and recyclability, providing valuable insights for further refinement and optimization.
Diastereoselective Synthesis of Sulfoxide‐Functionalized N‐Heterocyclic Carbene Ruthenium Complexes: An Experimental and Computational Study
Authors: Mechrouk Victoria , Leforestier Baptiste , Chen Weighang , Poblador‐Bahamonde Amalia I. , Maisse‐Francois Aline , Bellemin‐Laponnaz Stéphane , Achard Thierry 
Published: June 2024

AbstractThe synthesis of sulfoxide‐functionalized NHC ligand precursors were carried out by direct and mild oxidation from corresponding thioether precursors with high selectivity. Using these salts, a series of cationic [Ru(II)(η6‐p‐cymene)(NHC‐SO)Cl]+ complexes were obtained in excellent yields by the classical Ag2O transmetallation route. NMR analyses suggested a chelate structure for the metal complexes, and X‐ray diffractometry studies of complexes 4 b, 4 c, 4dBArF and 4 e unambiguously confirmed the preference for the bidentate (κ2‐C,S) coordination mode of the NHC‐SO ligands. Interestingly, only one diastereomer, in the form of an enantiomeric pair, was observed both in 1H NMR and in the solid state for the complexes. DFT calculations showed a possible intrinsic energy difference between the two pairs of diastereomer. The calculated energy barriers suggested that inversion of the sulfoxide is only plausible from the higher energy diastereomer together with bulky substituents. Inverting the configuration at the Ru center instead shows a lower and accessible activation barrier to provide the most stable diastereomer through thermodynamic control, consistent with the observation of a single species by 1H NMR as a pair of enantiomers. All these complexes catalyse the β‐alkylation of secondary alcohols. Complex 4dPF6 bearing an NHC‐functionalised S‐Ad group has been further studied with different primary and secondary alcohols as substrates, showing high reactivity and high to moderate β‐ol‐selectivities.
Catalyst‐Free Visible Light‐Driven Hydrosulfonylation of Alkenes and Alkynes with Sulfonyl Chlorides in Water
Authors: Xia Xi‐Rui , Du Juan , Zhang Yu‐Xing , Jiang Hong , Cheng Wan‐Min 
Published: June 2024

AbstractA convenient and sustainable method for synthesizing sulfonyl‐containing compounds through a catalyst‐free aqueous‐phase hydrosulfonylation of alkenes and alkynes with sulfonyl chlorides under visible light irradiation is presented. Unactivated alkenes, electron‐deficient alkenes, alkyl and aryl alkynes can be hydrosulfonylated with various sulfonyl chlorides at room temperature with excellent yields and geometric selectivities by using tris(trimethylsilyl)silane as a hydrogen atom donor and silyl radical precursor to activate sulfonyl chlorides. Mechanistic studies revealed that the photolysis of tris(trimethylsilyl)silane in aqueous solution to produce silyl radical is crucial for the success of this reaction.
Natriuretic peptides and C‐reactive protein in in heart failure and malnutrition: a systematic review and meta‐analysis
Authors: Prokopidis Konstantinos , Irlik Krzysztof , Ishiguchi Hironori , Rietsema Willemina , Lip Gregory Y.H. , Sankaranarayanan Rajiv , Isanejad Masoud , Nabrdalik Katarzyna 
Published: June 2024

AbstractBackgroundHeart failure (HF) and malnutrition exhibit overlapping risk factors, characterized by increased levels of natriuretic peptides and an inflammatory profile. The aim of this study was to compare the differences in plasma brain natriuretic peptide (BNP), N‐terminal‐pro B‐type natriuretic peptide (NT‐proBNP), and C‐reactive protein (CRP) in patients with HF and malnutrition versus normal nutrition.MethodsFrom inception until July 2023, the databases, PubMed, Scopus, Web of Science, and Cochrane Library were searched. To examine the association among malnutrition [controlling nutritional status (CONUT) score ≥2; Geriatric Nutritional Risk Index (GNRI) score <92] with BNP, NT‐proBNP and CRP in patients with HF, a meta‐analysis using a random‐effects model was conducted (CRD42023445076).ResultsA significant association of GNRI with increased levels of BNP were demonstrated [mean difference (MD): 204.99, 95% confidence interval (CI) (101.02, 308.96, I2 = 88%, P < 0.01)], albeit no statistically significant findings were shown using CONUT [MD: 158.51, 95% CI (−1.78 to 318.79, I2 = 92%, P = 0.05)]. GNRI [MD: 1885.14, 95% CI (1428.76–2341.52, I2 = 0%, P < 0.01)] and CONUT [MD: 1160.05, 95% CI (701.04–1619.07, I2 = 0%, P < 0.01)] were associated with significantly higher levels of NT‐proBNP. Patients with normal GNRI scores had significantly lower levels of CRP [MD: 0.50, 95% CI (0.12–0.88, I2 = 87%, P = 0.01)] whereas significantly higher levels of CRP were observed in those with higher CONUT [MD: 0.40, 95% CI (0.08–0.72, I2 = 88%, P = 0.01)]. Employing meta‐regression, age was deemed a potential moderator between CRP and GNRI.ConclusionsNormal nutrition scores in patients with HF are linked to lower BNP, NT‐proBNP, and CRP levels compared with malnourished counterparts. Despite the significant link between CRP and malnutrition, their relationship may be influenced in older groups considering the sensitivity of GNRI due to ageing factors.
Optimal event‐triggered control for wireless power transfer system in electric vehicles
Authors: Abdelrahim Mahmoud , Almakhles Dhafer , Mabrok Mohamed 
Published: June 2024

AbstractThis study focuses on stabilizing a bidirectional inductive wireless power transfer (WPT) system using an event‐triggered approach. It is only assumed the inductor currents on both the primary and pickup sides are measurable, and they are sent synchronously to the controller via a digital channel. To estimate the unmeasured states and maintain plant stability, a full‐order state observer and an observer‐based controller have been developed. The control parameters are optimized through a genetic algorithm to achieve the desired output response. An emulation methodology is then applied to create an output‐based event‐triggering condition. This condition ensures the stability of the closed‐loop system even in the presence of communication constraints. To prevent Zeno sampling, a minimal time interval between two transmissions is enforced using time‐regularization techniques. Furthermore, the performance of the event‐triggered controller is enhanced by solving a linear matrix inequality condition, which further reduces the number of transmission instances. The methodology offers a systematic and optimal design for the bidirectional inductive WPT system. It eliminates the need for manual tuning of control parameters, which is particularly beneficial given the system's complex nature. To address both continuous‐time and discrete‐time dynamics, the entire system is represented as a hybrid dynamical system, making it more intuitive for networked control systems. The efficiency of this approach is assessed through numerical simulations of a WPT system, demonstrating its effectiveness. The results show that the average intertransmission interval has been increased from 0.0799 to 0.1782 s, that is, the proposed event‐triggering strategy reduced the number of transmissions to more than 50% compared with conventional periodic sampling.
Is a glacier gone when it looks gone? Subsurface characteristics of high‐Arctic ice‐cored slopes as evidence of the latest maximum glacier extent
Authors: Bernard Eric , Friedt Jean‐Michel , Prokop Alexander , Tolle Florian , Griselin Madeleine 
Published: June 2024

AbstractIn the context of glacier retreat and increased precipitations, Arctic glacier basin slopes are subject to stress leading to visible transformations. In this work, subsurface features of a small Arctic glacier basin slopes are mapped using ground‐penetrating RADAR. In combination with surface topography data, eight transects were surveyed ranging from the areas furthest from the current glacier extent to the areas still in contact with the glacier. This allowed for a reconstitution of the successive stages ice‐cored slopes go through when glaciers retreat. It appears that slopes evolve from thick debris‐covered ice bodies connected with the glacier, to residual ice and ice/debris mixes covered in debris. At the same time, surface morphology of the slopes shifts from homogeneous ice‐cored slope gradients to more complex talus‐type slopes at the end of the process. The stages of these evolutions are in compliance with former glacier extents. The main driving factors of the slopes successive stages are the constant slope adjustments linked to debris movements, and the melting of ice cores. All these factors are exacerbated by the warmer and wetter conditions they are subject to.
Theranostic aspects of palladium‐based bimetallic nanoparticles in biomedical field: A state‐of‐the‐art
Authors: Nagarajan Shwetha B. , Ramakrishnan Sanjeevi , Jayaraman Anuradha 
Published: June 2024

AbstractThe exploration of newer antibacterial strategies is driven by antibiotic‐resistant microbes that cause serious public health issues. In recent years, nanoscale materials have developed as an alternative method to fight infections. Despite the fact that many nanomaterials have been discovered to be harmful, numerous researchers have shown a keen interest in nanoparticles (NPs) made of noble metals like silver, gold and platinum. To make environmentally safe NPs from plants, green chemistry and nanotechnology have been combined to address the issue of toxicity. The study of bimetallic nanoparticles (BNPs) has increased tremendously in the past 10 years. The production of BNPs mediated by natural extracts is straightforward, low cost and environmentally friendly. Due to their low toxicity, safety and biological stability, noble BNPs with silver, gold, platinum and palladium have the potential to be used in biomedical applications. They have a significant impact on human health and are used in medicine and pharmacy due to their biological characteristics, which include catalytic, antioxidant, antibacterial, antidiabetic, anticancer, hepatoprotective and regenerative activity.
Efficacy of submental island flap closing advanced mandibular MRONJ lesion in malignancy patients
Authors: Huang Hongyuan , Qiao Qiao , Zhao Ning , Zhou Ying , Zou Yiwen , Li Qingxiang , Li Siyuan , Zhou Biao , Zhang Yi , Guo Chuanbin , Guo Yuxing 
Published: June 2024

AbstractObjectiveThis study evaluated the effectiveness of a submental island flap in closing advanced mandibular medication‐related osteonecrosis of the jaw (MRONJ) wounds in patients with malignant tumors.Subjects and methodsA total of 85 patients with stage II and III MRONJ of mandible with malignant tumor as their primary disease were retrospectively analyzed. All patients underwent surgical treatment, and the soft tissue wound closure was performed either with a submental island flap (SIF) or mucoperiosteal flap (MF). Univariate and multifactorial models were applied to analyze the factors influencing patients' prognosis.ResultsUnivariate analysis (p = 0.004, OR 0.075–0.575, 95% CI) and binary logistic regression (p = 0.017, OR 0.032–0.713, 95% CI) suggested that the surgical prognosis of SIF wound closure was significantly better than that of MF.ConclusionClosure of wound after resection of mandibular MRONJ lesions in patients with malignant tumors using SIF had a better clinical prognosis compared with MF.
Left anterior descending coronary artery‐left circumflex coronary artery bifurcation angle and severity of coronary artery disease; is there any correlation? A cross‐sectional study
Authors: Mansouri Pejman , Nematipour Ebrahim , Rajablou Nadia , Ghorashi Seyyed Mojtaba , Azari Samad , Omidi Negar 
Published: June 2024

AbstractBackground and AimsThe aim of this study is to evaluate the association of coronary computed tomography angiography derived (CCTA) plaque characteristics and the left anterior descending coronary artery (LAD) and left circumflex coronary artery (LCX) bifurcation angle with severity of coronary artery disease (CAD).MethodsAll the stable patients with suspected CAD who underwent CCTA between January to December 2021 were included. Correlation between CCTA‐derived aggregated plaque volume (APV), LAD‐LCX angle, remodeling index (RI), coronary calcium score with Gensini score in conventional angiography were assessed. One hundred and twenty‐two patients who underwent both CCTA and coronary angiography were analyzed.ResultsOur analysis showed that the median (percentile 25% to percentile 75%) of the APV, LAD‐LCx angle, and calcium score were 31% (17%−47%), 58° (39°−89°), and 31 (0−186), respectively. Also, the mean ± SD of the RI was 1.05 ± 0.20. Significant correlation between LAD‐LCx bifurcation angle (0.0001−0.684), APV (0.002−0.281), RI (0.0001−0.438), and calcium score (0.016−0.217) with Gensini score were detected. There was a linear correlation between the mean LAD‐LCx bifurcation angle and the Gensini score. The sensitivity and specificity for the cut‐off value of 47.5° for the LAD‐LCX angle were 86.7% and 82.1%, respectively.ConclusionThere is a direct correlation between the LAD‐LCx angle and the Gensini score. In addition to plaque characteristics, anatomic‐based CCTA‐derived indices can be used to identify patients at higher risk for CAD.