bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hepatitis C Virus Differentially Modulates Activation of Forkhead Transcription Factors and Insulin-Induced Metabolic Gene Expression
Authors: Banerjee Arup , Meyer Keith , Mazumdar Budhaditya , Ray Ratna B. , Ray Ranjit 
Published: April 2010

ABSTRACT

Chronic hepatitis C virus (HCV) infection is often associated with insulin resistance and hepatic steatosis. Insulin regulates gene expression of key enzymes in glucose and lipid metabolism by modulating the activity of specific Forkhead box transcriptional regulators (FoxO1 and FoxA2) via the phosphatidylinositol 3-kinase (PI3K)-Akt signaling pathway in the liver. In this study, we observed that HCV infection of human hepatocytes impaired insulin-induced FoxO1 translocation from the nucleus to the cytoplasm and significantly reduced accumulation of FoxA2 in the nucleus. Phosphorylation of FoxO1 at Ser
256
, a downstream target for Akt, was inhibited in hepatocytes infected with HCV or expressing the core protein or full-length (FL) genome of HCV. Further, an interaction between FoxO1 and 14-3-3 protein, important for FoxO1 translocation, was inhibited in HCV core-expressing cells. Hepatocytes infected with HCV, expressing the core protein alone or polyprotein displayed an increased level of glucose-6-phosphatase (G6P) mRNA. On the other hand, microsomal triglycerol transfer protein (MTP) activity and apolipoprotein B (ApoB) secretion were significantly reduced in hepatocytes expressing HCV proteins. Together, these observations suggest that HCV infection or ectopic expression of the core protein either alone or together with other viral proteins from an FL gene construct differentially modulates FoxO1 and FoxA2 activation and affects insulin-induced metabolic gene regulation in human hepatocytes.
Conformational Changes in the Capsid of a Calicivirus upon Interaction with Its Functional Receptor
Authors: Ossiboff Robert J. , Zhou Yi , Lightfoot Patrick J. , Prasad B. V. Venkataram , Parker John S. L. 
Published: April 2010

ABSTRACT

Nonenveloped viral capsids are metastable structures that undergo conformational changes during virus entry that lead to interactions of the capsid or capsid fragments with the cell membrane. For members of the
Caliciviridae
, neither the nature of these structural changes in the capsid nor the factor(s) responsible for inducing these changes is known. Feline junctional adhesion molecule A (fJAM-A) mediates the attachment and infectious viral entry of feline calicivirus (FCV). Here, we show that the infectivity of some FCV isolates is neutralized following incubation with the soluble receptor at 37°C. We used this property to select mutants resistant to preincubation with the soluble receptor. We isolated and sequenced 24 soluble receptor-resistant (
srr
) mutants and characterized the growth properties and receptor-binding activities of eight mutants. The location of the mutations within the capsid structure of FCV was mapped using a new 3.6-Å structure of native FCV. The
srr
mutations mapped to the surface of the P2 domain were buried at the protruding domain dimer interface or were present in inaccessible regions of the capsid protein. Coupled with data showing that both the parental FCV and the
srr
mutants underwent increases in hydrophobicity upon incubation with the soluble receptor at 37°C, these findings indicate that FCV likely undergoes conformational change upon interaction with its receptor. Changes in FCV capsid conformation following its interaction with fJAM-A may be important for subsequent interactions of the capsid with cellular membranes, membrane penetration, and genome delivery.
Making Sense of Antisense: Seemingly Noncoding RNAs Antisense to the Master Regulator of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Do Not Regulate That Transcript but Serve as mRNAs Encoding Small Peptides
Authors: Xu Yiyang , Ganem Don 
Published: April 2010

ABSTRACT
The mammalian transcriptome is studded with putative noncoding RNAs, many of which are antisense to known open reading frames (ORFs). Roles in the regulation of their complementary mRNAs are often imputed to these antisense transcripts, but few have been experimentally examined, and such functions remain largely conjectural. Kaposi's sarcoma-associated herpesvirus (KSHV) encodes two transcripts that lack obvious ORFs and are complementary to the gene (RTA) encoding the master regulator of the latent/lytic switch. Here, we show that, contrary to expectation, these RNAs do not regulate RTA expression. Rather, they are found on polysomes, and genetic analysis indicates that translational initiation occurs at several AUG codons in the RNA, leading to the presumptive synthesis of peptides of 17 to 48 amino acids. These findings underscore the need for circumspection in the computational assessment of coding potential and raise the possibility that the mammalian proteome may contain many previously unsuspected peptides generated from seemingly noncoding RNAs, some of which could have important biological functions. Irrespective of their function, such peptides could also contribute substantially to the repertoire of T cell epitopes generated in both uninfected and infected cells.
SEMI-AUTOMATIC SURFACE SCANNER FOR MEDICAL TANGIBLE USER INTERFACES
Authors: SHERSTYUK ANDREI , TRESKUNOV ANTON , BERG BENJAMIN 
Published: April 2010

Mixing real and virtual components into one consistent environment often involves creating geometry models of physical objects. Traditional approaches include manual modeling by 3D artists or use of dedicated devices. Both approaches require special skills or special hardware and may be costly.We propose a new method for fast semi-automatic 3D geometry acquisition, based upon unconventional use of motion tracking equipment. The proposed method is intended for quick surface prototyping for Virtual, Augmented and Mixed reality applications (VR/AR/MR), where quality of visualization of scanned objects is not required or is of low priority.
Porosity development, diagenesis and basin modelling of a Lower Cretaceous (Albian) carbonate platform from northern Spain
Authors: Rosales I. , Pérez-García A. 
Published: April 2010

Abstract

This paper describes an integrated field, petrographic and geochemical study of an Albian carbonate platform from the Basque-Cantabrian basin (northern Spain). It examines the distribution and evolution of porosity and the relationships between facies variations, sequences and variations in diagenesis. These platform carbonates were deposited on the footwall crests of active tilted blocks formed during continental rifting related to the Mesozoic opening of the Bay of Biscay and North Atlantic. The studied units document an early Albian aggradational steep-sloping platform and a late Albian, low-gradient expansive shelf separated by a hiatal unconformity spanning the middle–early late Albian (
c.
5 Ma). The late Albian platform unit also exhibits a major internal unconformity. Platform geometries and facies architecture were mainly controlled by tectonics, hydrodynamic energy level and water depth.

Petrographic, cathodoluminescence and geochemical analyses suggest that early meteoric diagenesis developed during sub-aerial exposure in strata below these two major unconformities. The platform carbonates have been affected during burial by a number of diagenetic processes that include four phases of dissolution, several fracture generations, and six cement sequences with development of at least 13 calcite and dolomite cement zones (Z0–Z12). A contrasting diagenetic response from the different platform environments illustrates the role of primary sediment composition and unconformity development in controlling porosity and cement distribution. Limestone stabilization and cementation were relatively early processes that were mostly completed within the first kilometre of burial depth beneath the depositional surface. Below this burial depth, fluid circulation was concentrated along restricted pathways (fractures and fault zones). Migration of hydrothermal-related fluids along fault zones created localized dolomite patches and large-scale porosity associated with cavities and collapse breccias, but did not significantly increase the small-scale porosity.
The influence of basin architecture and eustacy on the evolution of Tethyan Mesozoic and Cenozoic carbonate sequences
Authors: Gerdes K. D. , Winefield P. , Simmons M. D. , Van Oosterhout C. 
Published: April 2010

Abstract
During the Mesozoic and Cenozoic Eras, regional tectonic processes, eustatic variations and the volume and distribution of non-carbonate sediment controlled the progressive expansion and rapid reduction of the accommodation space available for the deposition of carbonate sequences, in the area that is now the Mediterranean and Middle East.
We present a simplified super-regional tectonostratigraphic history of this area from earliest Triassic time to the present day, to demonstrate the influence of these large-scale processes on the evolution of major Tethyan Mesozoic and Cenozoic carbonate sequences. The time period is divided into 11 tectonostratigraphic phases (TSP) two of which (1 and 11) are incomplete. Each TSP commenced with major changes in basin architecture in response to regional tectonic processes. Subsequent pulses of transgression and regression generated sequence stratigraphic hierarchies. These stratigraphic hierarchies reflect the interaction between regional and local tectonics, eustatic variations, carbonate growth processes, climate and non-carbonate sediment supply. A map is presented of a major second-order transgressive sequence (TST) within each TSP to illustrate the maximum extent of marine onlap. These maps also include the main plate configurations; active regional tectonic features and the resultant time averaged carbonate gross depositional systems that developed during the transgression.
The sequence of maps illustrate that the volume of available accommodation space during the Mesozoic and Cenozoic Eras reached a maximum during the Late Cretaceous and has been progressively reduced during the Cenozoic Era to the present day minimum.
Spatial and temporal distribution of ooids along a Jurassic carbonate ramp: Amellago outcrop transect, High-Atlas, Morocco
Authors: Pierre A. , Durlet C. , Razin P. , Chellai E. H. 
Published: April 2010

Abstract
Carbonate ramp systems are widespread throughout the geological record, but very few areas have seismic-scale, continuous and structurally undeformed outcrops that allow reliable interpretation of facies distributions and stacking patterns. The Amellago outcrop shows the detailed depositional and stratigraphic relationships of an ooid-dominated ramp system that is almost completely exposed along a dip profile (37 km long and 1000 m thick) in the Lower to Middle Jurassic of the southern High Atlas, Morocco. Ammonite and brachiopod fauna provide excellent biostratigraphic control on small scale stacking patterns.
At Amellago, the evolution of depositional environments is evident at different scales of space and time during this period of tectonic quiescence dominated by thermal subsidence. An important observation is that the Amellago ramp system contains micrite-rich, ooid-free intervals that alternate with ooid-rich intervals. The ooid-rich intervals are mainly in the late transgressive and highstand system tracts, whereas the ooid-free intervals occur in the early transgressive phase. More than 25 such alternations were recorded in high frequency cycles and at the scale of one large cycle at the Aalenian/Bajocian transition. These compositional changes and the associated different ramp geometries are interpreted to result from the combined effects of eustatic sea level and climatic changes.
Sequence stratigraphy and carbon isotope stratigraphy of an Aptian mixed carbonate-siliciclastic platform to basin transition (Galve sub-basin, NE Spain)
Authors: Embry J.-C. , Vennin E. , Van Buchem F. S. P. , Schroeder R. , Pierre C. , Aurell M. 
Published: April 2010

Abstract
A 380 m thick Aptian platform to basin transition has been studied along a 16 km long transect of excellent and continuous outcrops in NE Spain. The series has been dated using biostratigraphy (foraminifera and ammonites) and carbon-isotope stratigraphy, and has been subdivided at four scales of depositional sequences. The Aptian marine succession is subdivided into two-large scale sequences separated by a middle Aptian sub-aerial exposure surface. A characteristic trend of the floral-faunal fossil assemblages is present, which evolves from orbitolinid-ooid dominated ramps in Sequence I-1, to a coral-stromatoporoid-microbialite dominated platform in Sequence I-2, to a rudist-dominated platform top in Sequence II-1, and finally to a second episode of orbitolinid-ooid dominated ramp system in Sequence II-2. There was an influx of siliciclastic sediments at the base and at the top of this succession. The detailed carbon-isotope curve measured along the Miravete section and covering almost the complete Aptian succession, is compared with published Aptian curves recorded in both basinal and carbonate platform settings along the northern and southern NeoTethys margins. It shows that the Galve sub-basin curve represents all the major isotope excursions of the lower and upper Aptian, in a dominantly shallow-water succession.
High-resolution seismic stratigraphy of the Shu'aiba and Natih formations in the Sultanate of Oman: implications for Cretaceous epeiric carbonate platform systems
Authors: Droste H. 
Published: April 2010

Abstract
The Shu'aiba and Natih Formation carbonates are important hydrocarbon reservoirs in the Sultanate of Oman. They consist of stacked deepening and shallowing-upward depositional cycles within an extensive middle Cretaceous epeiric carbonate platform.
Geological models for these units traditionally assume a layer-cake stratigraphy and a high lateral continuity of facies. This is based on the assumption that epeiric platforms consist of ramps with low depositional gradients, broad facies belts and gradual facies transitions. However, high-resolution 3D seismic data covering large areas of the platform have revealed a more complicated internal stratigraphic architecture and have led to a new geometrical model for these epeiric platform systems.
The transgressive part of the cycles is dominated by a low angle ramp depositional profile with localized development of algal-dominated mounds. Differential carbonate growth led to a topography of shallow carbonate shoals and intra-platform ‘basins’ with water depths reaching several tens to 100 m. During the regressive part of the cycles these basins were progressively filled-in by prograding carbonate rudist shoal complexes with depositional slopes of 0.5° to more than 30°. Clinoform belts on seismic show a wide range of progradational geometries ranging from closely spaced, laterally continuous ‘tramlines’ to irregular wedges and noses. The cycle tops are characterized by bedrock incisions and the influx of fine clastic sediments that fill in remnants of the intra-platform basins.
The seismic images show that previous stratigraphic models for these carbonates oversimplified and flattened the stratigraphy. As a result the stratigraphic trapping potential and the internal reservoir heterogeneity for these systems has been underestimated.
Channelized systems in an inner carbonate platform setting: differentiation between incisions and tidal channels (Natih Formation, Late Cretaceous, Oman)
Authors: Grélaud C. , Razin P. , Homewood P. 
Published: April 2010

Abstract

The Natih Formation (late Albian–early Turonian, Oman) corresponds to a very broad inner carbonate platform extending over more than 800 km between the Arabian Shield to the south and the Tethys continental margin to the north. Two types of channelized systems have developed recurrently on this inner carbonate platform:

incisions
corresponding to strictly erosive drainage systems which formed at the top of the sub-aerially-exposed platform during significant drops of relative sea level;

tidal channels
corresponding to partly erosive but mainly constructive/depositional systems which formed during phases of flooding of the inner platform.

The comparative analysis of the basal surface and fill of incisions and tidal channels, based on the study of several outcrops in the Oman Mountains allows the recognition of the similarities and the main differences between these two types of channelized systems which both develop in an inner carbonate platform setting.

One of the main criteria of differentiation is the stratigraphic context in which incisions and channels develop. Incisions develop at the top of regressive sequences, whereas the channels analysed here developed during phases of flooding or maximum flooding, during which higher energy processes such as tidal currents developed on the platform.
The incision surface is clearly defined, with diagenetic effects such as silicification and dolomitization below, and with the systematic fill of subjacent burrows and cracks by sparitic calcite crystals. The basal erosion surface of channels is often multiple and composite, systematically burrowed, and associated with no significant diagenetic effect.
Channels are generally less deep than incisions but their width is very similar. Incisions are longer than channels and present a section that is, on the whole, symmetrical and regular, whereas channels locally have one margin that is steeper and more erosive than the other.
Finally, the less diagnostic parameter of differentiation is their fill. Indeed, incisions and channels are similarly filled during phases of flooding of the inner platform. Incisions and channels form significant heterogeneities at the reservoir scale. It is therefore necessary to be able to recognize these two types of channelized systems, in order to predict their geometry, extent and fill type, and the eventual occurrence of associated reservoir bodies in the more distal direction (forced regressive wedges/bioclastic shoals).
Fixed Points of Discontinuous Multivalued Operators in Ordered Spaces with Applications
Authors: Hong ShihuangH , Qiu Zheyong 
Published: April 2010

AbstractExistence theorems of fixed points for multivalued increasing operators in partially ordered spaces are presented. Here neither the continuity nor compactness is assumed for multivalued operators. As an application, we lead to the existence principles for integral inclusions of Hammerstein type multivalued maps.
Dynamic Traffic Network Equilibrium System
Authors: He Yun-Peng , Xu Jiu-Ping , Huang Nan-Jing , Wu Meng 
Published: April 2010

AbstractWe discuss the dynamic traffic network equilibrium system problem. We introduce the equilibrium definition based on Wardrop's principles when there are some internal relationships between different kinds of goods which transported through the same traffic network. Moreover, we also prove that the equilibrium conditions of this problem can be equivalently expressed as a system of evolutionary variational inequalities. By using the fixed point theory and projected dynamic system theory, we get the existence and uniqueness of the solution for this equilibrium problem. Finally, a numerical example is given to illustrate our results.
A randomized controlled trial of a wellness intervention for women with fibromyalgia syndrome
Authors: Stuifbergen Alexa K , Blozis Shelley A , Becker Heather , Phillips Lorraine , Timmerman Gayle , Kullberg Vicki , Taxis Carole , Morrison Janet 
Published: April 2010

Objective: To examine the effects of a wellness intervention, Lifestyle Counts, for women with fibromyalgia syndrome on the level of self-efficacy for health-promoting behaviours, health-promoting activity and perceived quality of life. Design: A randomized controlled single-blinded trial with treatment and attention-control groups. Setting: Community in the southwestern United States. Subjects: Convenience sample of 187 women (98 treatment, 89 attention control) with fibromyalgia syndrome (mean age = 53.08 years, SD 9.86). Intervention: The two-phase Lifestyle Counts intervention programme included lifestyle change classes for eight weeks, with goal-setting and telephone follow-up for three months. Participants in the attention-control group were offered an equivalent amount of contact in classes on general disease-related information and health education topics and unstructured follow-up phone calls. Participants were followed for a total of eight months after baseline. Outcome measures: Self-report instruments measuring self-efficacy for health behaviours, health-promotion behaviours and health-related quality of life (SF-36 and the Fibromyalgia Impact Questionnaire) were completed at baseline, two months (after the classes), five months (after telephone follow-up) and at eight months. Results: Both groups improved significantly (P<0.05) over time on the measures of self-efficacy, health behaviours, fibromyalgia impact and quality of life. There were significant group × time interactions for scores on the Health Promoting Lifestyle II subscales of physical activity and stress management. Conclusions: The Lifestyle Counts wellness intervention holds promise for improving health-promoting behaviours and quality of life of women with fibromyalgia syndrome.
Comparison of the effects of a physiotherapist-supervised exercise programme and a self-supervised exercise programme on quality of life in patients with Parkinson’s disease
Authors: Dereli Elif E , Yaliman Ayse 
Published: April 2010

Objectives: To compare the effects of a physiotherapist-supervised exercise programme in an exercise unit and self-supervised home exercise programme on quality of life in patients with Parkinson’s disease. Design: Assessor-blinded, quasi-randomized trial (alternate allocation). Setting: An outpatient exercise unit; home settings. Participants: Thirty patients with idiopathic Parkinson’s disease, Hoehn & Yahr I—III, stable medication use. Interventions: Patients were included in the physiotherapist-supervised or home group. The exercise programme was performed for 10 weeks, three times/week either under the supervision of a physiotherapist or at home without supervision. Main outcome measures: Parkinson’s Disease Quality of Life Questionnaire (PDQLQ), Nottingham Health Profile (NHP), Unified Parkinson’s Disease Rating Scale (UPDRS), Beck Depression Inventory (BDI). Results: Patients in the supervised physiotherapy group improved more than the home exercise group in Parkinson’s Disease Quality of Life Questionnaire (total score, Parkinson’s symptoms, emotional function), Nottingham Health Profile total, Unified Parkinson’s Disease Rating Scale (all domains) and Beck Depression Inventory scores. Conclusions: The exercise programme under physiotherapist supervision was found to be more effective at improving activities of daily living, motor, mental, emotional functions and general health quality in patients with Parkinson’s disease compared with a self-supervised home programme.