bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of different potentials on the structures and energies of clusters
Authors: Ma Zhinan , Cai Wensheng , Shao Xueguang 
Published: July 2011

AbstractCluster studies have attracted much interest in the past decades because of their extraordinary properties. To describe the interaction between atoms or molecules and predict the energies and structures, potential functions are developed. However, different potentials generally produce different structures and energies for a cluster. To study the effect of potentials on the structure of a cluster, He clusters in the size range of 13–140 are investigated by Lennard–Jones (LJ), Pirani, and Hartree–Fock‐dispersion individual damping (HFD‐ID) potential with dynamic lattice searching (DLS) method. Potential function curves, cluster structures, bonds, and energies of the global minima are compared. The results show that cluster energies decrease with the values of the potential functions, the differences between structures depend upon the disagreements of the potentials, and the preferable motif of a cluster changes from icosahedron to decahedron with the increase of the derivative of the short‐range part of the potentials. © 2011 Wiley Periodicals, Inc. J Comput Chem 2011
Honokiol inhibits signal transducer and activator of transcription‐3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP‐1
Authors: Rajendran Peramaiyan , Li Feng , Shanmugam Muthu K. , Vali Shireen , Abbasi Taher , Kapoor Shweta , Ahn Kwang Seok , Kumar Alan Prem , Sethi Gautam 
Published: July 2011

AbstractThe activation of signal transducers and activators of transcription 3 (STAT3) has been closely linked with the proliferation, survival, invasion, and angiogenesis of hepatocellular carcinoma (HCC) and represents an attractive target for therapy. In the present report, we investigated whether honokiol mediates its effect through interference with the STAT3 activation pathway. The effect of honokiol on STAT3 activation, associated protein kinases, and phosphatase, STAT3‐regulated gene products and apoptosis was investigated using both functional proteomics tumor pathway technology platform and different HCC cell lines. We found that honokiol inhibited both constitutive and inducible STAT3 activation in a dose‐ and time‐dependent manner in HCC cells. The suppression was mediated through the inhibition of activation of upstream kinases c‐Src, Janus‐activated kinase 1, and Janus‐activated kinase 2. Vanadate treatment reversed honokiol‐induced down‐regulation of STAT3, suggesting the involvement of a tyrosine phosphatase. Indeed, we found that honokiol induced the expression of tyrosine phosphatase SHP‐1 that correlated with the down‐regulation of constitutive STAT3 activation. Moreover, deletion of SHP‐1 gene by siRNA abolished the ability of honokiol to inhibit STAT3 activation. The inhibition of STAT3 activation by honokiol led to the suppression of various gene products involved in proliferation, survival, and angiogenesis. Finally, honokiol inhibited proliferation and significantly potentiated the apoptotic effects of paclitaxel and doxorubicin in HCC cells. Overall, the results suggest that honokiol is a novel blocker of STAT3 activation and may have a great potential for the treatment of HCC and other cancers. J. Cell. Physiol. 227: 2184–2195, 2012. © 2011 Wiley Periodicals, Inc.
Immunity against a therapeutic xenoprotein/Fc construct delivered by gene transfer is reduced through binding to the inhibitory receptor FcγRIIb
Authors: Liang Yaming , Qiu Hongmin , Glinka Yelena , Lazarus Alan H. , Ni Heyu , Prud'homme Gerald J. , Wang Qinghua 
Published: July 2011

AbstractBackgroundTherapeutic xenoproteins are immunogenic and can induce neutralizing antibodies. When delivered by intramuscular injection of a plasmid vector, this mimics classical DNA vaccination. To demonstrate this, we chose Exendin‐4 (Ex4), which is a glucagon‐like peptide‐1 mimetic xenoprotein in clinical use for treating type 2 diabetes. We constructed an Ex4 and mouse immunoglobulin (Ig)G1‐Fc fusion fragment (Ex4/Fc), and hypothesized that it would have minimal immunogenicity as a result of its capacity to bind the inhibitory Fc receptor FcγRIIb expressed by B lymphocytes.MethodsPlasmid vectors encoding Ex4/Fc constructs, with wild‐type or mutant Fc, were injected intramuscularly into mice, and local electroporation was applied to enhance gene transfer. Gene transfer was performed in both wild‐type and FcγRIIb knockout mice. Antibody production was detected in serum by an enzyme‐linked immunosorbent assay.ResultsRecombinant Ex4/Fc bound only to B cells expressing FcγRIIb. This binding was dependent on a motif in the Fc region, which we mutated to abolish binding (Ex4/Fcmut). Ex4 antibody was detected in mice treated with Ex4, as well as Ex4/Fcmut, but not in those treated with Ex4/Fc. Thus, wild‐type Fc was associated with reduced immunogenicity. To confirm this was related to the presence of inhibitory Fc receptors, we also performed experiments in FcγRIIb‐null mice. Mice lacking this receptor produced antibodies against all Ex4 constructs, including the wild‐type Fc (Ex4/Fc).ConclusionsThe present study shows that inhibitory FcγRIIb receptors interacting with the wild‐type IgG1‐Fc reduce immunity against Ex4/Fc, suggesting an approach for reducing the immunogenicity of therapeutic proteins in the context of gene therapy. Copyright © 2011 John Wiley & Sons, Ltd.
Antimagic labelling of vertex weighted graphs
Authors: Wong Tsai‐Lien , Zhu Xuding 
Published: July 2011

AbstractSuppose G is a graph, k is a non‐negative integer. We say G is k‐antimagic if there is an injection f: E→{1, 2, …, |E| + k} such that for any two distinct vertices u and v, . We say G is weighted‐k‐antimagic if for any vertex weight function w: V→ℕ, there is an injection f: E→{1, 2, …, |E| + k} such that for any two distinct vertices u and v, . A well‐known conjecture asserts that every connected graph G≠K2 is 0‐antimagic. On the other hand, there are connected graphs G≠K2 which are not weighted‐1‐antimagic. It is unknown whether every connected graph G≠K2 is weighted‐2‐antimagic. In this paper, we prove that if G has a universal vertex, then G is weighted‐2‐antimagic. If G has a prime number of vertices and has a Hamiltonian path, then G is weighted‐1‐antimagic. We also prove that every connected graph G≠K2 on n vertices is weighted‐ ⌊3n/2⌋‐antimagic. Copyright © 2011 Wiley Periodicals, Inc. J Graph Theory
On Cayley digraphs on nonisomorphic 2‐groups
Authors: Kovács István , Servatius Mary 
Published: July 2011

AbstractA necessary and sufficient condition is given for two Cayley digraphs X1 = Cay(G1, S1) and X2 = Cay(G2, S2) to be isomorphic, where the groups Gi are nonisomorphic abelian 2‐groups, and the digraphs Xi have a regular cyclic group of automorphisms. Our result extends that of Morris [J Graph Theory 3 (1999), 345–362] concerning p‐groups Gi, where p is an odd prime. Copyright © 2011 Wiley Periodicals, Inc. J Graph Theory
Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease
Authors: Rockenstein Edward , Ubhi Kiren , Pham Emiley , Michael Sarah , Doppler Edith , Novak Philipp , Inglis Chandra , Mante Michael , Adame Anthony , Alvarez X. Anton , Moessler Herbert , Masliah Eliezer 
Published: July 2011

AbstractNeurodegenerative disorders such as Alzheimer's disease (AD) are characterized by the loss of neurotrophic factors, and experimental therapeutical approaches to AD have investigated the efficacy of replacing or augmenting neurotrophic factor activity. Cerebrolysin, a peptide mixture with neurotrophic‐like effects, has been shown to improve cognition in patients with AD and to reduce synaptic and behavioral deficits in transgenic (tg) mice overexpressing the amyloid precursor protein (APP). However, it is unclear how long‐lasting the beneficial effects of Cerebrolysin are and whether or not behavioral and neuropathological alterations will reappear following treatment interruption. The objective of the present study was to investigate the consequences of interrupting Cerebrolysin treatment (washout effect) 3 and 6 months after the completion of a 3‐month treatment period in APP tg mice. We demonstrate that, in APP tg mice, Cerebrolysin‐induced amelioration of memory deficits in the water maze and reduction of neurodegenerative pathology persist for 3 months after treatment interruption; however, these effects dissipate 6 months following treatment termination. Immunohistochemical analysis demonstrated that the decrease in neocortical and hippocampal amyloid plaque load observed in Cerebrolysin‐treated APP tg mice immediately after treatment was no longer apparent at 3 months after treatment interruption, indicating that the beneficial effects of Cerebrolysin at this time point were independent of its effect on amyloid‐β deposition. In conclusion, the results demonstrate that the effects of Cerebrolysin persist for a significant period of time following treatment termination and suggest that this prolonged effect may involve the neurotrophic factor‐like activity of Cerebrolysin. © 2011 Wiley‐Liss, Inc.
The tropospheric biennial oscillation in the East Asian monsoon region and its influence on the precipitation in China and large‐scale atmospheric circulation in East Asia
Authors: Si Dong , Ding Yihui 
Published: July 2011

AbstractThe precipitation in China manifests a remarkable quasi‐biennial signal. For interannual variability, about 70% stations over China indicate the dominance of a quasi‐2‐year period. The maximum precipitation variability associated with the quasi‐biennial oscillation is located over the Yangtze River valley (YRV) and Huaihe River valley (HRV) as well as South China. This paper attempts to reveal the spatial–temporal evolution of the precipitation in China and related large‐scale atmospheric circulation associated with the tropospheric biennial oscillation (TBO) in East Asia by using a season‐dependent empirical orthogonal function (S‐EOF) analysis approach.The leading two modes of the TBO of summer precipitation in China and associated large‐scale circulations are examined by the S‐EOF analysis and regression analyses based on the S‐EOF time coefficients. The first TBO mode is characterized by an elongated band of positive precipitation anomalies along the YRV and negative precipitation anomalies over both North and South China. The second TBO mode is characterized by an elongated band of positive precipitation anomalies along the HRV and negative precipitation anomalies to the north of the Yellow River and to the south of the Yangtze River, respectively. Meanwhile, the leading modes of the TBO in East Asia may be determined by the meridional teleconnection Rossby wave pattern extending from the WNP to the midlatitudes of East Asia that is forced by the heating source fluctuation over the WNP during boreal summer. And the cold air activity, which is associated with the East Asian winter monsoon, may further influence the leading modes of the TBO through a modulation of the large‐scale atmosphere circulation over East Asia during the following boreal summer.Also found is that the TBO in East Aisa depends on both the large‐scale air–sea coupling over the tropical Indo‐Pacific Ocean regions and the tropical–midlatitude interaction in the western North Pacific (WNP)‐East Asia region. A fundamental element for the TBO in East Asia is the WNP monsoon. It is not only an important component of the TBO cycle in the tropics but also serves as a major source of the TBO signal for the subtropical East Asia. The meridional teleconnection Rossby wave train over the WNP‐East Asia region acts as a conveyer belt that transports the tropical TBO signal to the midlatitudes of East Asia, and produces the TBO footprints in the large‐scale circulation and precipitation in East Asia. Furthermore, the cold air activity over the East Asia during boreal summer also services as an important link in the chain events of the tropical–midlatitude interaction, with enhancing the role of the TBO modes in East Asia. Copyright © 2011 Royal Meteorological Society
Large‐scale, inter‐annual relations among surface temperature, water vapour and precipitation with and without ENSO and volcano forcings
Authors: Gu Guojun , Adler Robert F. 
Published: July 2011

AbstractHow the global hydrological cycle, generally denoted by precipitation, responds to surface temperature change has been debated for decades. This debate is crucial to correctly assess the global warming‐related climate variability/change in the water cycle, but reflects our limited understanding of the relationships that exist among key components of the water cycle on various spatial and temporal scales. Primarily using satellite‐based measurements, we find that correlations between precipitation and surface temperature anomalies averaged over large domains (i.e. tropical and global ocean/land areas) during 1988–2008 are very weak once the effects from two large‐scale forcings, ENSO and volcanic eruptions, are removed, whereas tropospheric water vapour content varies with surface temperature no matter whether the ENSO and volcanic effects are included or not. We thus conclude that precipitation variability on the inter‐annual time scale, once the net large‐scale dynamic effects particularly associated with ENSO become weak or limited, does not follow surface temperature and related water vapour variations, even though inter‐decadal signals may still exist. This is consistent with the fact that ENSO precipitation signals are usually weak over combined land plus ocean areas for both tropical and global regimes, though ENSO can greatly modulate global precipitation patterns through shifting large‐scale circulation systems. These findings are also similar to the weak global‐mean precipitation responses under the recent global warming that have been evident in both observations and models, compared to large associated tropospheric water vapour changes, roughly following the Clausius‐Clapeyron (CC) relation. Copyright © 2011 Royal Meteorological Society
Safety and efficacy of hepatectomy for colorectal metastases in the elderly
Authors: Cannon Robert M. , Martin Robert C. G. , Callender Glenda G. , McMasters Kelly M. , Scoggins Charles R. 
Published: July 2011

AbstractBackground and ObjectivesThe aim of this study was to determine the safety and efficacy of hepatic metastasectomy in elderly patients with colorectal liver metastases (CLM).MethodsA retrospective review of a hepatobiliary database was performed on consecutive patients treated with metastasectomy for CLM. Patients were stratified by age (<70 years old vs. ≥70). Patient and tumor characteristics as well as operative factors were compared, as were morbidity, mortality, and length of stay. Logistic regression and Cox proportional hazards were used to evaluate the association of age and postoperative outcomes.ResultsThere were 59 elderly (median age 75) and 220 non‐elderly (median age 58) patients analyzed over a 13 year period. The Charlson comorbidity index was higher in the elderly group (mean 4.7 vs. 4.4 P = 0.005). Postoperative morbidity and mortality were 52.5 and 0% vs. 48.2 and 4.1% in the elderly and non‐elderly groups, respectively (P = 0.56 and P = 0.21). There were no differences in median DFS (21.8 months vs. 28.9 months; P = 0.157) or OS (36 months vs. 47.7 months; P = 0.070) between the elderly and non‐elderly groups, respectively.ConclusionsAge itself does not appear to be a significant contraindication to liver resection, including major hepatectomy, when patients are appropriately selected. J. Surg. Oncol. 2011; 104:804–808. © 2011 Wiley Periodicals, Inc.
Habitat occupancy by riparian muskrats reveals tolerance to urbanization and invasive vegetation
Authors: Cotner Lisa A. , Schooley Robert L. 
Published: July 2011

AbstractWildlife communities are being altered by rapid environmental change including habitat loss and fragmentation, urbanization, and spread of invasive species. To predict consequences of these anthropogenic changes to landscapes, it is necessary to identify not only species that are negatively affected, but also species that are unaffected or even thrive. We used occupancy modeling to examine the spatial distribution of muskrats (Ondatra zibethicus) in riparian habitat within an agricultural region of east‐central Illinois from 2007 to 2008. We examined whether site occupancy was related to local habitat conditions and anthropogenic landscape alterations including urbanization and dominance of invasive reed canary grass (Phalaris arundinacea). We sampled 90 study sites (200‐m stream segments) for occupancy by muskrats based on presence of tracks, scat, and feeding sign. Per‐survey detection probability was 0.79 (SE = 0.04) in 2007 and 0.76 (SE = 0.04) in 2008. Detection was related positively to Julian date and negatively to abundance of woody debris and emergent rocks. Site occupancy by muskrats was 0.59 (SE = 0.09) in 2007 and 0.69 (SE = 0.06) in 2008, a year with above‐average precipitation. Occupancy was related positively to urban land cover surrounding sites, which could reflect higher baseflows and reduced risk from predation and trapping in urban areas. Occupancy was unrelated to site dominance by invasive reed canary grass, but muskrats occurred more often at larger, deeper streams and those with greater bank heights and less sandy bank soils. Turnover between years was driven by stream size and water availability. Muskrats exhibited tolerance to key aspects of environmental change, and muskrats might even be urban adapters when occupying riparian habitat that remains adequately connected in urbanizing landscapes. © 2011 The Wildlife Society.
Importance of juniper to birds nesting in piñon–juniper woodlands in northwest New Mexico
Authors: Francis Clinton D. , Ortega Catherine P. , Hansen John 
Published: July 2011

AbstractPiñon–juniper (Pinus spp.–Juniperus spp.) woodlands are common throughout western North America, yet relatively little is known about the habitat use and requirements for many members of its avian community. During summer 2005–2007, we assessed avian nesting substrates within piñon (Pinus edulis)–juniper (Juniperus osteosperma) woodlands in northwestern New Mexico. Of all nests in live trees, 86% were in junipers. The selection of juniper as a nest tree was significantly higher than expected from the region's piñon–juniper ratio (1:1.06) for the community as a whole, for both open cup and cavity nesting species, and for 8 species (of which 6 are piñon–juniper obligate or semi‐obligate species). Nest survival, however, was not higher in juniper than in piñon for the nesting community as a whole or for chipping sparrows (Spizella passerina), the single species that was well represented nesting in piñon. The high use of juniper as a nesting substrate differs from previous studies, which have suggested that a presence of piñon is among the most important habitat features for many piñon–juniper species. Because of their importance to nesting birds, managers should avoid preferential thinning of junipers within piñon–juniper woodlands. © 2011 The Wildlife Society.
Transoral robotic resection and reconstruction for head and neck cancer
Authors: Genden Eric M. , Kotz Tamar , Tong Charles C. L. , Smith Claris , Sikora Andrew G. , Teng Marita S. , Packer Stuart H. , Lawson William L. , Kao Johnny 
Published: July 2011

AbstractObjectives/Hypothesis:To evaluate the patterns of failure, survival, and functional outcomes for patients treated with transoral robotic surgery (TORS) and compare these results with those from a cohort of patients treated with concurrent chemoradiation (CRT).Study Design:Prospective non‐randomized case control study.Methods:Between April 2007 and April 2009, 30 patients with head and neck squamous cell carcinoma were treated with primary TORS and adjuvant therapy as indicated on an institutional review board–approved protocol. Patients were evaluated before treatment, after treatment, and at subsequent 3‐month intervals after completing treatment to determine their disease and head and neck–specific functional status using the Performance Status Scale for Head and Neck Cancer and the Functional Oral Intake Score (FOIS). Functional scores were compared to a matched group of head and neck patients treated with primary CRT.Results:The TORS patient population included 73% stage III‐IV and 23% nonsmokers. The median follow‐up was 20.4 months (range, 12.8–39.6 months). The 18‐month locoregional control, distant control, disease‐free survival, and overall survival were 91%, 93%, 78%, and 90%, respectively. Compared to the primary CRT group, TORS was associated with better short‐term eating ability (72 vs. 43, P = .008), diet (43 vs. 25, P = .01), and FOIS (5.5 vs. 3.3, P < .001) at 2 weeks after completion of treatment. In contrast to TORS patients who returned to baseline, the CRT group continued to have decreased diet (P = .03) and FOIS (P = .02) at 12 months.Conclusions:Our early experience in treating selected head and neck cancers with TORS is associated with excellent oncologic and functional outcomes that compare favorably to primary CRT.
Persistent positional nystagmus
Authors: Heidenreich Katherine D. , Kerber Kevin A. , Carender Wendy J. , Basura Gregory J. , Telian Steven A. 
Published: July 2011

AbstractInvolvement of the superior semicircular canal (SSC) in benign paroxysmal positional vertigo (BPPV) is rare. SSC BPPV is distinguished from the more common posterior semicircular canal (PSC) variant by the pattern of nystagmus triggered by the Dix‐Hallpike position: down‐beating torsional nystagmus in SSC BPPV versus up‐beating torsional nystagmus in PSC BPPV. SSC BPPV may be readily treated at the bedside, which is a key component in excluding central causes of down‐beating nystagmus. We present an unusual video case report believed to represent refractory SSC BPPV based on the pattern of nystagmus and the absence of any other central signs.
Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene due to a founder effect in Chinese head and neck paraganglioma patients?
Authors: Zha Yang , Chen Xing‐ming , Lam Ching‐wan , Lee Soo‐chin , Tong Sui‐fan , Gao Zhi‐qiang 
Published: July 2011

AbstractObjectives/Hypothesis:Three Chinese patients with head and neck paragangliomas have been reported to carry the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene. In addition, in our hospital, two further patients were identified who have the same mutation. It is unclear whether the c.3G>C mutation in Chinese patients is a recurrent mutation or if it is due to a founder effect. We conducted haplotype analysis on these patients to answer this question.Study Design:Individual case‐control study.Methods:Germ‐line mutations were confirmed in the patients and their families examined in this study using direct sequencing. We also constructed and analyzed haplotypes in four Chinese families. Genotype frequencies were compared to the control group.Results:Three of four families shared the same haplotype, which rarely occurred in the control group. The last family shared a very short area on the physical map with the other three families.Conclusions:There is a founder effect in Chinese head and neck paraganglioma patients carrying the SDHD c.3G>C mutation.