bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the impact of non-tariff measures on Sri Lankan mango exports: insights, challenges, and recommendations
Authors: Wickrama Sidath Prasanna , Kandangama Nawarathna Bandara , Wickramaarachchi Thushara , Weerahewa Jeevika 
Published: May 2024

IntroductionWith the increase in non-tariff measures (NTMs) in recent years, understanding their impact on trade policies and agricultural exports is of utmost importance for countries like Sri Lanka, where the proliferation of NTMs has posed substantial impediments to its mango export industry. However, studying NTMs can be challenging due to their complex nature, diverse range, and limited information availability.MethodsThis research aims to investigate the significant effect of NTMs on Sri Lankan mango exports, identify the pivotal drivers influencing mango exports, and analyze the performance of mango exports in Sri Lanka. This study utilized a panel dataset of 16 importing countries spanning the period from 2000 to 2021. The primary focus was on examining NTM-related challenges and obstacles faced by the mango export industry in Sri Lanka. The identification and quantification of these obstacles were achieved through a multifaceted approach in which assessment of NTM-related rejections, both domestic and overseas, evaluation of NTM incidences using frequency and coverage ratio measures, and the deployment of various gravity model equations to quantify the effect of NTMs were taken into consideration. Probit, Ordinary Least Square, Random Effects, and Poisson Pseudo Maximum Likelihood estimation techniques were utilized for data analysis.ResultsThe findings indicate a significant inverse correlation between the increase in the total count of NTMs and Sri Lankan mango exports if the country aims to export more mangoes to relevant markets, while Sanitary and Phytosanitary Measures (SPS), Technical Barriers to Trade (TBT), and Pre-shipment Inspection (PSI) contributed to increased mango exports. Among other explanatory variables, the GDP of both importing and exporting countries had a positive influence on Sri Lankan mango exports. Surprisingly, the distance to the importing country had no significant effect, though it shows a negative sign.DiscussionThis study provides valuable insights into the impact of NTMs on Sri Lankan mango exports. It highlights the considerable influence of NTMs on the overall fresh fruit export sector. We recommend proactively aligning internal quality testing regulations with the standards required by destination countries to promote future expansion.
The Role of the MYL4 Gene in Porcine Muscle Development and Its Molecular Regulatory Mechanisms
Authors: Ye Yourong , Wu Guoxin , Wang Haoqi , Duan Mengqi , Shang Peng , Chamba Yangzom 
Published: May 2024

Muscle growth stands as a pivotal economic trait within pig production, governed by a complex interplay of multiple genes, each playing a role in its quantitative manifestation. Understanding the intricate regulatory mechanisms of porcine muscle development is crucial for enhancing both pork yield and quality. This study used the GSE99749 dataset downloaded from the GEO database, conducting a detailed analysis of the RNA-seq results from the longissimus dorsi muscle (LD) of Tibetan pigs (TP), Wujin pigs (WJ) and large white pigs (LW) at 60 days of gestation, representing diverse body sizes and growth rates. Comparative analyses between TPvsWJ and TPvsLW, along with differential gene expression (DEG) analysis, functional enrichment analysis, and protein–protein interaction (PPI) network analysis, revealed 1048 and 1157 significantly differentially expressed genes (p < 0.001) in TPvsWJ and TPvsLW, respectively. With stricter screening criteria, 37 DEGs were found to overlap between the 2 groups. PPI analysis identified MYL5, MYL4, and ACTC1 as the three core genes. This article focuses on exploring the MYL4 gene. Molecular-level experimental validation, through overexpression and interference of the MYL4 gene combined with EDU staining experiments, demonstrated that overexpression of MYL4 significantly promoted the proliferation of porcine skeletal muscle satellite cells (PSMSC), while interference with MYL4 inhibited their proliferation. Furthermore, by examining the effects of overexpressing and interfering with the MYL4 gene on the muscle hypertrophy marker Fst gene and the muscle degradation marker FOXO3 gene, the pivotal role of the MYL4 gene in promoting muscle growth and preventing muscle degradation was further confirmed. These findings offer a new perspective on the molecular mechanisms behind porcine muscle growth and development, furnishing valuable data and insights for muscle biology research.
Risk Factors and Treatment for Premenstrual Tension Syndrome
Authors: Гутикова Л.В. , Кухарчик Ю.В. , Павловская М.А. 
Published: May 2024

В статье представлен анализ результатов анкетирования 824 женщин по вопросам предменструального синдрома (ПМС). Цель исследования: выявление факторов риска развития ПМС и оценка результатов лечения женщин с использованием экстракта плодов Vitex agnus castus Ze 440. Установлено, что факторами риска развития ПМС являются длительный период становления и болезненность менструации (увеличивают риск развития ПМС в 2,5 и в 2,1 раза соответственно). Высокая распространенность ПМС и его негативное влияние на качество жизни женщин диктуют необходимость проведения своевременной и эффективной коррекции этого состояния. Использование препарата экстракта плодов Vitex agnus castus Ze 440 для коррекции ПМС является эффективным и безопасным; может применяться в качестве препарата первого выбора для минимизации множественных симптомов менструальной дисфункции у женщин, страдающих ПМС.
The article presents an analysis of the results of a survey of 824 women on the issues of premenstrual syndrome. Purpose of the study: to identify risk factors for the development of PMS and evaluate the results of treatment of women using the fruit extract of Vitex agnus castus Ze 440. It was established that the risk factors for the development of PMS are a long period of formation of menstruation and painful menstruation (increase the risk of developing PMS by 2.5 and 2,1 times, respectively). The high prevalence of PMS and its negative impact on the quality of life of women dictates the need for timely and effective correction of this condition. The use of the fruit extract drug Vitex agnus castus Ze 440 for the correction of PMS is effective (remission of symptoms is 2.8 (95% CI 1.23–4.47) times higher compared to women who did not receive treatment).
Method for Predicting Preeclampsia
Authors: Ганчар Е.П. 
Published: May 2024

Цель. На основании изучения метаболомного профиля свободных аминокислот у женщин в 1-м триместре беременности создать метод прогнозирования преэклампсии. Материалы и методы. На 1-м этапе произведен забор плазмы крови у 318 женщин в сроке беременности 11–13 недель. Плазма криоконсервирована в условиях умеренно низкой температуры (–80 °С). Произведен анализ исходов беременности и родов. На 2-м этапе в исследование включено 38 пациентов: 1-я группа (основная) – 18 пациентов с диагнозом «преэклампсия»; 2-я группа (контрольная) – 20 женщин с беременностью без осложнений. В плазме крови методом высокоэффективной жидкостной хроматографии определено содержание 45 свободных аминокислот, их производных и метаболитов. Результаты. Методом логистической регрессии получена формула, включающая определение концентрации аспартата и асимметричный диметиларгинин в плазме крови женщин в 1-м триместре беременности, при расчете индекса p>0,461 прогнозируют развитие преэклампсии, а при p<0,461 делают заключение о низком риске развития данного осложнения. Заключение. Предложен метод прогнозирования преэклампсии с чувствительностью 88,9% и специфичностью 85%.
Purpose. Based on the study of the metabolomic profile of free amino acids in women in the 1st trimester of pregnancy, create a method for predicting preeclampsia. Materials and Methods. At the 1st stage, blood plasma was taken from 318 women at 11–13 weeks of gestation. The plasma is cryopreserved at moderately low temperatures (–80 °C). An analysis of the outcomes of pregnancy and childbirth was made. At stage 2, the study included 38 patients: group 1 (main) – 18 patients diagnosed with preeclampsia; group 2 (control) – 20 women with pregnancy without complications. In blood plasma, the content of 45 free amino acids, their derivatives and metabolites were determined by high-performance liquid chromatography. Results. Using the method of logistic regression, a formula was obtained, including the determination of the concentration of aspartate and asymmetric dimethylarginine in the blood plasma of women in the 1st trimester of pregnancy, when calculating the index p>0.461, the development of preeclampsia is predicted, and at p<0.461, a conclusion is made about the low risk of developing this complication. Conclusion. A method for predicting preeclampsia with a sensitivity of 88.9% and a specificity of 85% was proposed.
Assessing the Severity of Preeclampsia Through the Study of Lipid Peroxidation Activity and Anti-Inflammatory Responses
Authors: Пискунова А.В. , Тумакова В.Р. , Тюрина Н.А. , Роганова Н.А. , Тултаева М.В. , Доронина Д.В. 
Published: May 2024

Целью данного исследования является изучение процесса перекисного окисления липидов в патогенезе преэклампсии средней и тяжелой степени тяжести, а также анализ уровня цитокинов как биомаркеров преэклампсии. В исследовании принимали участие 80 беременных женщин со сроком гестации более 25 недель (третий триместр). Первую группу составили пациентки с преэклампсией средней степени тяжести (40 женщин). Во вторую группу вошли 20 беременных женщин с тяжелой степенью преэклампсии. Контрольная группа состояла из 20 женщин с нормальным течением беременности. Интерлейкины (ИЛ) определялись с помощью иммуноферментных тест-систем, малоновый диальдегид – методом высокоэффективной жидкостной хроматографии, лактоферрин – с помощью иммуноферментного анализа. Для женщин с преэклампсией характерны высокие концентрации цитокинов ИЛ-1, ИЛ-6 и ИЛ-8, белка лактоферрина, малонового диальдегида на фоне снижения ИЛ-4 и антиоксидантного потенциала. При тяжелой форме преэклампсии нарушения становятся более выраженными. Показатели уровня цитокинов, лактоферрина и малонового диальдегида, установленные в результате исследования, подтверждают связь воспалительного процесса и оксидативного стресса в патогенезе преэклампсии, что может привести к появлению новых комплексных подходов к диагностике данной патологии беременности.
The purpose of this study is to investigate the process of lipid peroxidation in the pathogenesis of moderate and severe preeclampsia, as well as to analyze the levels of cytokines as biomarkers of preeclampsia. The study involved 80 pregnant women with a gestation period of more than 25 weeks (third trimester). The first group consisted of patients with moderate preeclampsia (40 women). The second group included 20 pregnant women with severe preeclampsia. The control group consisted of 20 women with a normal pregnancy course. Interleukins (IL) were determined using enzyme-linked immunosorbent assay kits, malondialdehyde by high-performance liquid chromatography, and lactoferrin by enzyme-linked immunosorbent assay. Women with preeclampsia are characterized by high concentrations of cytokines IL1, IL6, and IL8, lactoferrin protein, and malondialdehyde against the background of reduced IL4 and antioxidant potential. With severe preeclampsia, these disturbances become more pronounced. The indicators of cytokine levels, lactoferrin, and malondialdehyde established in the study confirm the connection between the inflammatory process and oxidative stress in the pathogenesis of preeclampsia, which may lead to the emergence of new comprehensive approaches to diagnosing this pregnancy pathology.
Polycystic Ovary Syndrome: Updated Recommendations of the International Science-Based Guide 2023
Authors: Иванова А.Ю. , Мохорт Т.В. 
Published: May 2024

Синдром поликистозных яичников (СПКЯ) – наиболее распространенное эндокринное заболевание у женщин репродуктивного возраста, оказывающее влияние на весь жизненный цикл. СПКЯ связан не только с репродуктивными нарушениями, но и с метаболическими и психологическими особенностями. В данной статье рассматриваются последние новшества в диагностике и лечении СПКЯ. Ключевые обновления включают упрощенный диагностический алгоритм и использование уровней антимюллерова гормона как альтернативы ультразвуковому исследованию у взрослых. Констатируется признание более широких особенностей СПКЯ, включая метаболические факторы риска (нарушение углеводного обмена и дислипидемии), сердечно-сосудистые заболевания, апноэ сна, высокую распространенность психологических особенностей и высокий риск неблагоприятных исходов при беременности. Также сохраняется обоснование акцента на здоровом образе жизни, эмоциональном благополучии и качестве жизни. В алгоритме лечебных опций наряду с оральными контрацептивами и метформином указывается на потенциал использования инозитола.
Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of reproductive age, affecting the entire life cycle. PCOS is associated not only with reproductive disorders, but also with metabolic and psychological characteristics. This article discusses the latest innovations in the diagnosis and treatment of PCOS. Key updates include a simplified diagnostic algorithm and the inclusion of anti-muller hormone levels as an alternative to ultrasound in adults. There is recognition of broader features of PCOS, including metabolic risk factors (impaired carbohydrate metabolism and dyslipidemia), cardiovascular diseases, sleep apnea, high prevalence of psychological characteristics and high risk of adverse pregnancy outcomes. The rationale for the emphasis on a healthy lifestyle, emotional well-being and quality of life also remains. The algorithm of therapeutic options, along with oral contraceptives and metformin, indicates the potential use of inositol.
PEMBENTUKAN MODAL PEDAGANG PENJUAL MAKANAN DI KAWASAN PESISIR PANTAI MALALAYANG II KECAMATAN MALALAYANG KOTA MANADO
Authors: Magofa Fransisco , Manoppo Victoria E.N. , Tambani Grace O. , Aling Djuwita R.R. , Dien Christian R. , Kotambunan Olvie V. 
Published: May 2024

Abstract
The aim of this research is to know and analyze the capital formation of traders who sell food on the coast of Malalayang II Beach, Malalayang District, Manado City. This research was conducted in the Malalayang II Village, Malalayang District, Manado City. The research time is approximately 5 months, from August to December 2022.The method used in this research is survey method. The data collected in this study consisted of primary data and secondary data. The data analysis technique used in this study is descriptive analysis. The data obtained in the research is made in a simpler form so that it is easy to understand. In order to answer the research objectives, the data needed includes: a description of the food seller's business, as well as their daily activities, while for the needs of age, education, condition of the house where they live, length of time doing business, side jobs are needed as food seller profile data and economic data in the form of capital, operating income and operating expenses.Based on the results of the study, it can be concluded that the formation of capital for traders who sell food on the coast of Malalayang II Beach, Malalayang District, Manado City comes from their own savings, the help of parents and close relatives. There is capital for investment, capital for operations and loan capital. Keywords: culinary, capital formation, coast, Malalayang Beach

Abstrak
Tujuan penelitian mengetahui serta menganalisis pembentukan modal pedagang yang menjual makanan di pesisir Pantai Malalayang II Kecamatan Malalayang Kota Manado. Penelitian ini dilaksanakan di Kelurahan Malalayang II Kecamatan Malalayang Kota Manado. Waktu penelitian kurang lebih 5 bulan, yaitu dari bulan Agustus sampai Desember 2022.
Metode yang digunakan dalam penelitian ini ialah metode survei. Data yang dikumpulkan pada penelitian ini terdiri dari data primer dan data sekunder. Teknik analisis data yang digunakan pada penelitian ini adalah analisis deskriptif. Data yang diperoleh dalam penelitian dibuat dalam bentuk yang lebih sederhana agar mudah dipahami. Guna menjawab tujuan penelitian, data yang diperlukan antara lain: deskripsi usaha penjual makanan, serta aktivitas mereka sehari-hari, sedangkan untuk kebutuhan umur, pendidikan, keadaan rumah tempat tinggal, lamanya menjalani usaha, pekerjaan sampingan diperlukan sebagai data profil penjual makanan dan data ekonomi berupa permodalan, pendapatan usaha serta pengeluaran operasional.
Berdasarkan hasil penelitian dapat disimpulkan bahwa pembentukan modal pedagang yang menjual makanan di pesisir Pantai Malalayang II Kecamatan Malalayang Kota Manado berasal dari tabungan sendiri, bantuan orang tua dan saudara dekat. Ada modal untuk investasi, modal untuk operasional dan modal pinjaman.

Kata kunci: kuliner, pembentukan modal, pesisir, Pantai Malalayang
ANALISIS FINANSIAL USAHA FILLET IKAN DI CV. CAMAR LAUT KOTA GORONTALO PROVINSI GORONTALO
Authors: Ibrahim Pratewo , Tambani Grace O. , Longdong Florence V. , Jusuf Nurdin , Sondakh Srie J. , Durand Swenekhe S. 
Published: May 2024

Abtrack
Efforts to increase value and optimize the utilization of marine catch production are by developing value-added products, both traditional and modern preparations. Fish fillets are one of the fishery product processing technologies that can provide added value. The results of this study have the goal of knowing the cost structure of fish fillet business in CV. Gorontalo Seagull and find out whether the fish fillet business is feasible or not.
The basis of this research is a census, with the respondents identified as business owners who are also directors and managers. Source of data obtained through primary and secondary data. Primary data in this study were taken by means of observation and interviews guided by questionnaires conducted on respondents.
The results of the research are based on the financial analysis of the fish fillet business in CV. Gorontalo Sea Gull, Gorontalo City is suitable for use because the value of the operating profit is IDR 120,750,000, the net profit or absolute profit from the fish fillet business is IDR 100,117,000, the profit rate or profit level obtained in the fish fillet business is 6%, the BCR is obtained that is equal to 1.06, the value of profitability is equal to 49%, BEP sales of IDR 276,581,769 and BEP units of 6,146 kg.

Keywords: financial analysis; fish fillets; Gorontalo city

Abstrak
Upaya untuk meningkatkan nilai dan mengoptimalkan pemanfaatan produksi hasil tangkapan laut adalah dengan pengembangan produk bernilai tambah, baik olahan tradisional maupun modern. Fillet ikan adalah salah satu teknologi pengolahan hasil perikanan yang dapat memberi nilai tambah. Hasil penelitian ini memiliki tujuan yaitu mengetahui struktur biaya usaha fillet ikan di CV. Camar Laut Gorontalo serta mengetahui analisis finansial usaha fillet ikan apakah layak atau tidak.
Dasar penelitian ini adalah sensus, dengan responden yang ditetapkan adalah pemilik usaha yang merangkap direktur dan para menejer. Sumber data diperoleh melalui data primer dan sekunder. Data primer dalam penelitian ini diambil dengan cara observasi dan wawancara yang dipandu dengan kuisioner yang dilakukan terhadap responden.
Hasil penelitian berdasarkan analisis finansial usaha fillet ikan yang ada di CV. Camar Laut Gorontalo Kota Gorontalo layak digunakan karena nilai dari oprating profit yaitu Rp120.750.000, net profit atau keuntungan absolut dari usaha fillet ikan ialah Rp100.117.000, profit rate atau tingkat keuntungan yang didapat pada usaha fillet ikan yaitu 6%, BCR yang didapat yaitu sebesar 1,06, nilai dari rentabilitas yaitu sebesar 49%, BEP penjualan sebesar Rp276.581.769 dan BEP satuan sebesar 6.146 kg.

Kata kunci; analisa finansial; fillet ikan; kota Gorontalo
KONTRIBUSI PEKERJAAN SAMPINGAN NELAYAN PANCING ULUR TERHADAP PEREKONOMIAN KELUARGA DI DESA TATELI WERU KECAMATAN MANDOLANG KABUPATEN MINAHASA
Authors: Pangidunan Esgit , Manoppo Victoria E.N. , Kotambunan Olvie V. , Sondakh Srie J. , Longdong Florence V. , Aling Djuwita R.R. 
Published: May 2024

Abtrack
The research objectives are: to analyze the extent to which fishermen's side jobs contribute to the family economy in Tateli Weru Village, Mandolang District. Benefits of Research: Adding information and knowledge about fishermen's side jobs. The basic method used in this research is survey. The population in this study were hand line fishermen in Tateli Weru Village, totaling 45 people. The data collected consists of primary data and secondary data. Data collection was carried out through observation, interviews, questionnaires and documentation, both photo documentation and retrieval of written documents from relevant agencies. The data obtained were analyzed based on quantitative descriptive analysis and qualitative descriptive analysis.
The results showed that the large contribution of side jobs to the income of hand line fishermen, both farm laborers (38.57%), construction workers (59.63%), and motorcycle taxi drivers (88.17%), is not more than half of the total fishermen's income. The suggestion from this research is that the contribution of side jobs can be greater or equal to the main job and fishermen should also be more diligent or more focused on developing and increasing income from this side job.

Keywords: contribution, side job, fisherman, Tateli Weru

Abstrak
Tujuan penelitian yaitu: untuk menganalisis sejauh mana kontribusi pekerjaan sampingan nelayan terhadap perekonomian keluarga di Desa Tateli Weru Kecamatan Mandolang. Manfaat Penelitian: Menambah informasi dan pengetahuan tentang pekerjaan sampingan nelayan. Metode dasar yang digunakan dalam penelitian ini yaitu survei. Populasi dalam penelitian ini adalah nelayan pancing ulur yang berada di Desa Tateli Weru yang berjumlah 45 orang. Data yang dikumpulkan terdiri dari data primer dan data sekunder. Pengumpulan data dilakukan melalui observasi, wawancara, kuisioner dan dokumentasi baik itu dokumentasi foto maupun pengambilan dokumen tertulis pada instansi terkait. Data yang diperoleh di analisis berdasarkan analisis deskriptif kuantitatif dan deskriptif kualitatif.
Hasil penelitian menunjukkan bahwa besarnya kontribusi pekerjaan sampingan terhadap pendapatan nelayan pancing ulur baik buruh tani (38,57%), buruh bangunan (59,63%), dan tukang ojek (88,17%), tidak lebih dari separuh total keseluruhan pendapatan nelayan. Saran dari penelitian ini adalah agar supaya kotribusi pekerjaan sampingan bisa lebih besar atau setara dengan pekerjaan utama dan sebaiknya para nelayan juga bisa lebih rajin atau lebih fokus lagi dalam pengembangan dan peningkatan pendapatan pada pekerjaan sampingan tersebut.

Kata kunci : kontribusi, pekerjaan sampingan, nelayan, Tateli Weru