bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women With a History of Preeclampsia Exhibit Accelerated Aging and Unfavorable Profiles of Senescence Markers
Authors: Suvakov Sonja , Vaughan Lisa E. , Parashuram Santosh , Butler Tobah Yvonne S. , Jayachandran Muthuvel , Kattah Andrea , Chamberlain Alanna M. , Bielinski Suzette J. , Milic Natasa , Garovic Vesna D. 
Published: May 2024

BACKGROUND:
Senescence, a mechanism of cellular aging, which is characterized by irreversible proliferation arrest and a proinflammatory secretory phenotype, has been documented in women with preeclampsia. As cellular senescence can persist and progress, we postulated that it is associated with accelerated aging phenotype and accumulation of comorbidities in women with a history of preeclampsia.

METHODS:
We included a cohort of women with a history of preeclampsia (n=40) age- and parity-matched to a group of referent women with normotensive pregnancies (n=40). Women with prior major cardiovascular events, neurological, or autoimmune conditions were excluded. We collected urine and blood samples to study markers of aging, data on multimorbidity at the time of enrollment, and prospectively followed them for events over the course of 6 years, on average.

RESULTS:

Women with a history of preeclampsia exhibited unfavorable aging profiles compared with referent women, including decreased urinary α-Klotho (
P
=0.018); increased leptin (
P
=0.016) and leptin/adiponectin ratio (
P
=0.027), and increased extracellular vesicles positive for tissue factor (
P
=0.025). Women with a history of preeclampsia likewise had a higher rate of comorbidities at the time of enrollment (
P
=0.003) and had a 4× higher risk of developing major cardiovascular events compared with referent women (
P
=0.003).

CONCLUSIONS:
Our data suggest that a history of preeclampsia is associated with accelerated aging as indicated by senescence marker differences and the accumulation of multimorbidity later in life. Targeting cellular senescence may offer novel, mechanism-based approaches for the diagnosis and treatment of adverse health outcomes in women with a history of preeclampsia.
Self‐Administration of Aspirin After Chest Pain for the Prevention of Premature Cardiovascular Mortality in the United States: A Population‐Based Analysis
Authors: Russo Rienna G. , Wikler Daniel , Rahimi Kazem , Danaei Goodarz 
Published: May 2024

Background
Aspirin, an effective, low‐cost pharmaceutical, can significantly reduce mortality if used promptly after acute myocardial infarction (AMI). However, many AMI survivors do not receive aspirin within a few hours of symptom onset. Our aim was to quantify the mortality benefit of self‐administering aspirin at chest pain onset, considering the increased risk of bleeding and costs associated with widespread use.

Methods and Results
We developed a population simulation model to determine the impact of self‐administering 325 mg aspirin within 4 hours of severe chest pain onset. We created a synthetic cohort of adults ≥ 40 years old experiencing severe chest pain using 2019 US population estimates, AMI incidence, and sensitivity/specificity of chest pain for AMI. The number of annual deaths delayed was estimated using evidence from a large, randomized trial. We also estimated the years of life saved (YOLS), costs, and cost per YOLS. Initiating aspirin within 4 hours of severe chest pain onset delayed 13 016 (95% CI, 11 643–14 574) deaths annually, after accounting for deaths due to bleeding (963; 926–1003). This translated to an estimated 166 309 YOLS (149391–185 505) at the cost of $643 235 (633 944–653 010) per year, leading to a cost‐effectiveness ratio of $3.70 (3.32–4.12) per YOLS.

Conclusions
For <$4 per YOLS, self‐administration of aspirin within 4 hours of severe chest pain onset has the potential to save 13 000 lives per year in the US population. Benefits of reducing deaths post‐AMI outweighed the risk of bleeding deaths from aspirin 10 times over.
Jurisdictional Entanglement: the Relationship between the Jurisdiction over a Dispute and the Jurisdiction to Assess Compliance with Provisional Measures
Authors: Panagis Nikiforos 
Published: May 2024

Abstract
This article examines the character, legal basis, and scope of the jurisdiction of the International Court of Justice to make findings concerning compliance with its orders on provisional measures. The article focuses on the relationship between this jurisdiction (“non-compliance jurisdiction”) and the jurisdiction over the principal dispute (“principal jurisdiction”). It argues that, while the two types of jurisdiction are established independently from each other, their exercise may be intertwined where the provisional measures indicated prescribe obligations materially similar to the ones forming the subject-matter of the principal dispute. The absorption of non-compliance jurisdiction by principal jurisdiction in such cases may have consequences on its exercise, especially where principal jurisdiction is absent.
Moving Late Antique and Early Medieval Penance (c. 550–800) into the Purview of Slavery and Dependency Studies
Authors: Winnebeck Julia 
Published: May 2024

Abstract
This article reconsiders the evidence provided by the late antique and early medieval penitentials (c. 550–800) for the study of slavery and other dependency relations. The main body of the article identifies and describes three sets of social practices of penance, which can be perceived as actions that contributed to the emergence, perpetuation, or stabilization of dependency relations: the social exclusion and othering of penitents, the assignment of penal measures, and the varying treatment of penitents according to their gender and social status. These social practices are then linked to contemporary theological and socio-legal frameworks that likely informed the practice of penance in Merovingian Gaul. The survey shows that the handbooks of penance provide important material for the study of dependency relations and that the ecclesiastical ritual of penance should be considered as a context in which these relations emerged.
Exploring Millimeter-Wavelength Radar Capabilities for Raindrop Size Distribution Retrieval: Estimating Mass-Weighted Mean Diameter from the Differential Backscatter Phase
Authors: Unal Christine , van den Brule Yannick 
Published: May 2024

Abstract
Accurate precipitation characterization relies on the estimation of raindrop size distribution (RDSD) from observations. While various techniques using centimeter-wavelength radars have been proposed for RDSD retrieval, the potential of millimeter-wavelength polarimetric radars, offering enhanced spatial and temporal resolution while capturing light to moderate rain, remains unexplored. This study focuses on retrieving the mass-weighted mean diameter Dm using a dual-frequency cloud radar. Since the differential reflectivity Zdr is ineffective for Dm retrieval at 94 GHz, and simulations demonstrate a strong dependence of the differential backscatter phase δco on Dm, the estimation of δco takes precedence in this paper. Notably, δco remains unaffected by attenuation and polarimetric calibration. Addressing the initial requirement of disentangling backscattering and propagation effects at millimeter wavelength, an automatic algorithm is proposed to detect Rayleigh plateaus in the spectral domain. Subsequently, a methodology for estimating δco and its associated error is presented. Leveraging simulation results, confidence intervals for Dm that align with δco confidence intervals are retrieved. The assessment of Dm and its confidence interval at 35 and 94 GHz is conducted employing disdrometer-derived Dm. The results demonstrate a comprehensive concordance within a margin of 0.2 mm, underscoring the cloud radar’s efficacy in delineating nuanced variations in the raindrop mean diameter versus altitude. The validation process encounters difficulties for Dm below 1 mm, as the disdrometer-derived Dm may exhibit an overestimation, while the cloud-radar-derived Dm may exhibit an underestimation. The combination of 35 and 94 GHz serves to diminish the confidence interval associated with the retrieved Dm.
The Subseasonal Feedback of Extreme Anomalous Tibetan Plateau Snow Cover Events on the Atmosphere
Authors: Liu Yumeng , Li Wenkai 
Published: May 2024

Abstract
The Tibetan Plateau snow cover exhibits notable subseasonal variability and plays a crucial role in influencing the atmosphere. This study employs numerical experiments to investigate the atmospheric feedback resulting from extreme anomalous snow cover events on the Tibetan Plateau, with a focus on both local and nonlocal atmospheric temperatures. The findings reveal that diabatic heating, directly induced by these events, leads to a local surface energy cooling response over the Tibetan Plateau, contributing to a reduction in local temperatures. This cooling effect amplifies local atmospheric temperature anomalies associated with extreme anomalous Tibetan Plateau snow cover events, constituting approximately 50% of the total final local surface air temperature anomalies. Furthermore, the Tibetan Plateau snow cover, through adiabatic processes, exerts a nonlocal influence on atmospheric temperature and circulation. The atmospheric temperature responses downstream of the Tibetan Plateau vary at different heights and regions, featuring both cold and warm anomaly responses. These variations depend on the relative contributions of horizontal advection and vertical advection in adiabatic heating.

Significance Statement
Snow cover is influenced by the atmosphere, and in turn, it affects the atmosphere. This study examines the feedback of extreme anomalous Tibetan Plateau snow cover events on the atmosphere at the subseasonal time scale, with a focus on atmospheric temperature. Our findings indicate that Tibetan Plateau snow cover has both local and nonlocal feedback effects on the atmosphere. In particular, extreme anomalous Tibetan Plateau snow cover amplifies local surface air temperature anomalies. The feedback contributes to approximately 50% of the total final local surface air temperature anomalies.
Model Predictability of Hail Precipitation with a Moderate Hailstorm Case. Part II: Impact of Improved Treatment of Graupel in the Thompson–Eidhammer Microphysics Scheme
Authors: Li Rumeng , Sun Juanzhen , Zhang Qinghong , Jensen Anders A. , Tessendorf Sarah 
Published: May 2024

Abstract
Explicit simulation of hailstorms remains a challenge partly due to the lack of accurate representations of both initial conditions and microphysical processes. Using a moderate hailstorm case that occurred in Beijing on 10 June 2016, the impact of the initial conditions on explicit hail prediction has been studied in Part I of this two-part work via high-resolution data assimilation. This Part II paper examines the role of improved graupel treatment by comparing the recently upgraded Thompson–Eidhammer microphysics scheme (MP38) with two previous versions. MP38 is a double-moment hail-aware scheme with the ability to additionally predict the graupel number concentration and density. This case study showed that the addition of these predictive variables improved the simulation of the mass-weighted mean diameter of hail and thereby reduced the overestimation of hail size. However, the hail size was significantly underpredicted without the prediction of hail density, indicating that both quantities must be prognosed for skillful hail prediction. It was further shown that the revised graupel treatment also influenced hailstorm dynamics. The smaller hail size in MP38 led to a stronger graupel melting process, which further promoted a stronger cold pool and downdraft. By assessing the efficiency of the upgraded Thompson–Eidhammer microphysics scheme, the current study shed some light on the importance of the accurate representation of microphysical processes in numerical models for explicit hailstorm prediction.
Private consulting firms’ intervention in public health policymaking: An exploratory review
Authors: Gallardo Lucille , Gautier Lara , Chabrol Fanny , Traverson Lola , Oliveira Sydia , Ridde Valery 
Published: May 2024

Context. While there is ample research in the social sciences on the role of private consulting firms in public policy, there is little information about their intervention in managing public health crises and epidemics. The COVID-19 pandemic revealed how much public administrations across the globe have been using these firms. The purpose of this exploratory review of the scientific literature is to identify research on the involvement of these firms in governing epidemics and health crises since 2000. Methods. This review investigates the following question: what research evidence about the role of these firms is there, and what research methods and analytical categories are used? Following the stages of the PRISMA methods, we identified 24 references since 2000. Findings. We classified authors’ analyses of the role played by those firms using three analytical categories: the management approach, the consultocracy phenomenon and the phenomenon of elite hybridization. Only two references were explicitly related to the work of consulting firms in the context of epidemics (e.g. COVID-19). The others focused on public health reforms. This finding confirms the scarcity of research evidence on the role played by consulting firms in the management of epidemics. Conclusions. This review reports on a blind spot of the scientific literature and calls for additional empirical research. Points for practitioners Consulting firms’ intervention during epidemics remains a blind spot of academic research. The COVID-19 crisis prompted a significant growth of consulting firms’ intervention in health policymaking. Three analytical categories can be useful to study consulting firms’ interventions, namely: the management approach, the consultocracy phenomenon and the phenomenon of elite hybridization. The phenomenon of elite hybridization reflects a promising heuristic approach.
Clinical and histopathological factors for recurrence and metastasis in lacrimal gland adenoid cystic carcinoma in Chinese patients
Authors: Zhou Xiaowen , Feng Yiyi , Yang Yidi , Zong Chunyan , Yu Yilin , Zhu Tianyu , Shi Jiahao , Jia Renbing , Chen Huifang , Li Yimin , Song Xin 
Published: May 2024

Purpose To investigate the association of metabolism-related proteins and clinicopathological features with poor prognosis in lacrimal gland adenoid cystic carcinoma (LGACC). Methods Clinicopathological data for 39 Chinese patients with LGACC enrolled were retrospectively analysed. Disease progression included death, recurrence, further nodal metastasis, and distant metastasis. Expression of ASCT2 and GLS1 were evaluated by immunohistochemistry. Kaplan–Meier survival curves and Cox proportional hazards regression models were used for risk factor analyses. Results At the end of follow-up, 14 patients (35.9%) developed local recurrence, 13 patients (33.3%) developed distant metastasis, 3 patients (7.7%) developed lymph node metastasis, and 9 patients (23.1%) died. Among the 13 patients who developed distant metastasis, lung metastasis was observed in 8 patients (61.5%), the brain in 8 patients (61.5%), and bone in 1 patient (7.7%). ASCT2 was expressed in 16 (57.14%) cases, while GLS1 had high expression in 19 (67.9%) cases. Advanced T category (≥T3), bone erosion, basaloid subtype, and ASCT2 (-) were associated with disease progression. Basaloid subtype was an independent risk factor for local recurrence ( P = 0.028; HR, 12.12; 95% CI, 1.3–111.5). ASCT2(-) was an independent risk factor for distant metastasis ( P = 0.016; HR, 14.46; 95% CI, 1.6–127.5) and was associated with basaloid subtype ( P = 0.019). Conclusions For LGACC, ≥T3 category, basaloid subtype, and bone erosion were high-risk predictors. ASCT2(-) was an independent risk factor for distant metastasis, which suggested that it could be a potential biomarker for LGACC.
The relationship between therapeutic alliance, frequency of consultation and uptake of telemedicine among patients seeking treatment for early psychosis: A moderated mediation model
Authors: AshaRani PV , Tan Yeow Wee Brian , Samari Ellaisha , Wang Peizhi , Cetty Laxman , Satghare Pratika , Verma Swapna K , Tang Charmaine , Subramaniam Mythily 
Published: May 2024

Background Telehealth services ensure the delivery of healthcare services to a wider range of consumers through online platforms. Nonetheless, the acceptance and uptake of telehealth remain elusive. This study aims to understand the (a) uptake and (b) acceptability of telemedicine, (c) if therapeutic alliance mediates the relationship between the frequency of consultations with clinicians and the uptake of telemedicine in patients with early psychosis, and (d) role of education in moderating the relationship between therapeutic alliance and the uptake of telemedicine for their mental healthcare. Methods A convenience sample of outpatients ( n = 109) seeking treatment for early psychosis and their care providers ( n = 106) were recruited from a tertiary psychiatric care centre. Sociodemographic and clinical characteristics, therapeutic alliance (Working Alliance Inventory), and telemedicine use were captured through self-administered surveys. The moderated mediation analysis was performed using PROCESS macro 3.4.1 with therapeutic alliance and level of education as the mediating and moderating factors, respectively. Results The acceptance of telemedicine was high (possibly will use: 47.7%; definitely will use: 26.6%) whilst the uptake was low (11%). Therapeutic alliance mediated the relationship between the frequency of consultation and the uptake of telemedicine ( β: 0.326; CI: 0.042, 0.637). This effect was moderated by the level of education ( β: −0.058; p < 0.05). Conclusion Therapeutic alliance mediates the relationship between the frequency of consultations and the uptake of telemedicine services with the level of education moderating this mediation. Focusing on the patients with lower education to improve their telemedicine knowledge and therapeutic alliance might increase the uptake.
YouTube as a source of information for cryptococcal infection: A cross-sectional study
Authors: Liao Kaijun , Feng Zhiqiang , Lu Dongli , Xia Jianping , Wu Zhaochun , Jiang Zhenghua , Chen Kun , Qiu Hongqiang 
Published: May 2024

Objective Immunocompromised individuals, particularly HIV patients, worldwide are at risk from cryptococcal infection. There are a number of videos of cryptococcal infection and more and more individuals may search these videos, but the quality of videos on YouTube is unclear. This study set out to assess the content and quality of YouTube videos regarding cryptococcal infection. Methods The keywords “ Cryptococcus,” “Cryptococcosis” and “Cryptococcal infection” were searched on YouTube. The videos were evaluated and graded by two impartial raters. A 14-point content score was used to categorize videos as bad, good or exceptional. The reliability and quality were evaluated utilizing the DISCERN instrument and a 5-point global quality score. Videos were then divided into groups based on uploading sources and content types. Results A total of 46 videos were located, and the ratings provided by the two raters were identical. Our scoring algorithm determined that 54.3% (n = 25), 32.6% (n = 15) and 13.0% (n = 6) of the videos were poor, decent and exceptional, respectively. Regarding quality, no difference was identified between the various video categories. The global quality scale, number of views, days posted, content score and DISCERN showed a significant positive relationship. Conclusions Professional individuals or healthcare organizations should be encouraged to submit high-quality videos for the expanding internet population, as only a small proportion of available videos had exceptional quality.
Relationship Between Emotional Intelligence and Self-Esteem among Nursing Students
Authors: Bsharat Fekry 
Published: May 2024

Introduction Nursing students must be able to detect the standpoints and demands of various sorts of individuals, as well as be competent in taking into account individual emotional reactions, self-confidence, stress management, and social role promotion. Objective The purpose of this study was to assess the relationship between emotional intelligence and self-esteem among fourth-year nursing students. Methods The study was a cross-sectional study. Data were collected from 225 nursing students through a convenience sampling method in spring 2023 at Arab American University. The instruments of the study included “Schutte Self Report Emotional Intelligence Test” and the “Rosenberg self-esteem scale.” Results The analysis indicated that the emotional intelligence mean was 151.3 ± 1.9 (ranging from 33 to 165), which is high. Also, the analysis indicated that the self-esteem of the nursing students was high 24.3 ± 3.5 (ranging from 0 to 30). Furthermore, the analysis showed that there was a moderately positive relationship between nurses’ emotional intelligence and self-esteem. Conclusion The emotional intelligence and self-esteem among fourth-year nursing students were high. Also, self-esteem was found to have a moderately positive relationship with emotional intelligence and utilizing emotions.
Anterior Opening-Wedge Proximal Tibial Osteotomy for Slope Correction of Genu Recurvatum
Authors: Dirnberger Jack , Homan Morgan D. , Kennedy Nicholas I. , LaPrade Robert F. 
Published: May 2024

Background: Symptomatic genu recurvatum is defined as greater than 5° of knee hyperextension and can be caused by osseous deformity, soft tissue laxity, or a combination. Common symptoms include pain, weakness, instability, decreased range of motion, leg length discrepancy, and stretching of the posterior capsuloligamentous structures of the knee. In instances where the genu recurvatum is caused by reverse tibial slope, literature supports the use of anterior opening-wedge proximal tibial osteotomy (OW PTO) to treat genu recurvatum by increasing tibial slope. Correction of anterior slope to a more anatomic, posterior orientation allows any stressed ligaments to return to their normal tension and restores the native biomechanics of the knee. Indications: The primary indication for OW PTO is genu recurvatum that is nonresponsive to physical therapy or genu recurvatum with concurrent ligamentous injury. The heel-height test provides an objective assessment for the identification and measurement of knee hyperextension. Technique Description: 2 guide pins are placed parallel to the tibial plateau, engaging the posterior cortex. A small micro sagittal saw is used to cut the anterior cortex. Osteotomes are used to complete the osteotomy, preserving a posterior hinge. An opening spreader device is placed and opened slowly while keeping the posterior cortex intact. The new slope is maintained by use of an opening wedge osteotomy plate and screws. Allograft bone graft is packed thoroughly into the osteotomy site. Fluoroscopy is used throughout the case to assess appropriate orientation and depth of the osteotomy, as well as the final opening width. Results: A review of 5 studies demonstrated adequate reduction in hyperextension, with a mean knee hyperextension ranging from 17° to 32° preoperatively and 0° to 7° postoperatively. Patients had significantly improved postoperative clinical outcomes compared with the preoperative state. Discussion/Conclusion: Anterior OW PTO has been shown to be a safe method of accurately correcting tibial plateau slope for the treatment of genu recurvatum. Patients can expect correction of knee hyperextension, restoration of anatomic posterior tibial slope, decreased posterior tibial translation, and increased subjective outcome scores. Patient Consent Disclosure Statement: The author(s) attest that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.