bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human tumor microRNA signatures derived from large‐scale oligonucleotide microarray datasets
Authors: Wang Wenzhang , Peng Bo , Wang Dan , Ma Xiaopin , Jiang Deke , Zhao Jing , Yu Long 
Published: December 2010

AbstractThe expression profiles of microRNAs (miRNAs) are associated with the initiation and progression of human tumors. DNA microarrays are widely used to explore the expression patterns of miRNAs. Because of the limited sample size and experimental expense, the statistical power of individual research projects is not sufficient to yield a robust conclusion. However, collected microarray datasets of expression profiles provide opportunities to compile the information of individual studies. Our study carried out a comprehensive meta‐analysis of miRNA expression microarray datasets from 28 published tumor studies; it comprises 33 comparisons and nearly 4,000 tumor and corresponding nontumorous samples. This work reports 52 miRNAs as common signatures that are dysregulated in tumors. In addition to the commonly altered miRNAs, five solid cancers displayed specific tissue patterns of altered miRNAs as well. The meta‐analysis also revealed some novel tumor‐related miRNAs such as hsa‐miR‐144, hsa‐miR‐130b, hsa‐miR‐132, hsa‐miR‐154, hsa‐miR‐192 and hsa‐miR‐345. We further validated the expression pattern of hsa‐miR‐154 in human hepatocellular carcinoma by RT‐PCR. Restoration of intracellular miR‐154 inhibited tumor cell malignance and the G1/S transition in cancer cells. Both bioinformatic prediction and western blotting demonstrated that miR‐154 could target CCND2. In addition, expression patterns of miR‐154 were inversely correlated with those of CCND2 in hepatocellular carcinoma. Overall, this study used a large‐scale data analysis to identify a qualified list of miRNAs that are consistently changed in tumors, which could lead to a better understanding of human tumor etiology.
Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma
Authors: Sunagozaka Hajime , Honda Masao , Yamashita Taro , Nishino Ryuhei , Takatori Hajime , Arai Kuniaki , Yamashita Tatsuya , Sakai Yoshio , Kaneko Shuichi 
Published: December 2010

AbstractThe identification of genes involved in tumor growth is crucial for the development of inventive anticancer treatments. Here, we have cloned a 17‐kDa secretory protein encoded by c19orf10 from hepatocellular carcinoma (HCC) serial analysis of gene expression libraries. Gene expression analysis indicated that c19orf10 was overexpressed in approximately two‐thirds of HCC tissues compared to the adjacent noncancerous liver tissues, and its expression was significantly positively correlated with that of alpha‐fetoprotein (AFP). Overexpression of c19orf10 enhanced cell proliferation of AFP‐negative HLE cells, whereas knockdown of c19orf10 inhibited cell proliferation of AFP‐positive Hep3B and HuH7 cells along with G1 cell cycle arrest. Supplementation of recombinant c19orf10 protein in culture media enhanced cell proliferation in HLE cells, and this effect was abolished by the addition of antibodies developed against c19orf10. Intriguingly, c19orf10 could regulate cell proliferation through the activation of Akt/mitogen‐activated protein kinase pathways. Taken together, these data suggest that c19orf10 might be one of the growth factors and potential molecular targets activated in HCC.
FoxO1: A molecule for all seasons
Authors: Kousteni Stavroula 
Published: December 2010

Abstract
The FoxO family of forkhead transcription factors is at the crossroads of many signal transduction pathways that are evolutionarily conserved. Such pathways have been co-opted in differentiated tissues for a variety of vital and specialized functions, such as differentiation, proliferation, and survival in cells as diverse as adipocytes, hepatocytes, β-cells, myoblasts, thymocytes, and cancer cells. FoxO metabolic functions are relevant to glucose metabolism, tumor suppression, hematopoiesis, angiogenesis, and antioxidant defense. Among the FoxO isoforms, FoxO1 is a main target of insulin signaling and regulates metabolic homeostasis and organismal survival at many different levels. FoxO1 entered into the field of skeletal biology by a property that is unique among its functions in other organs. With the osteoblast as its target cell, FoxO1 not only acts on it to regulate bone homeostasis but also through it as a transcriptional modulator of the endocrine function of the skeleton in regulating glucose metabolism. Through its direct skeletal actions, FoxO1 promotes osteoblast proliferation by maintaining protein synthesis and redox balance. Through its endocrine actions on target tissues of insulin, FoxO1 acts by way of osteocalcin to suppress glucose production by pancreatic beta cells and hepatocytes and to decrease insulin production and sensitivity. These two parallel but opposing actions, one in favor of the skeleton and the other in disadvantage of glucose-regulating tissues, may signify an adaptive mechanism that integrates responses between different organs and is beneficial for whole-body physiology during stress and aging. © 2011 American Society for Bone and Mineral Research.
Expectations
Authors: Constantino Michael J. , Arnkoff Diane B. , Glass Carol R. , Ametrano Rebecca M. , Smith JuliAnna Z. 
Published: December 2010

AbstractPatients' expectations have long been considered a contributory factor to successful psychotherapy. Expectations come in different guises, with outcome expectations centered on prognostic beliefs about the consequences of engaging in treatment. In this article, we define outcome expectations and present assessment methods and clinical examples of outcome expectations. Our research review includes a comprehensive meta‐analysis (N =8,016 patients across 46 independent samples) of the association between pretherapy or early‐therapy outcome expectations and posttreatment outcomes. The overall weighted effect size was d=.24, p<.001, indicating a small but significant positive effect of outcome expectations on adaptive treatment outcomes. We also provide a narrative review of mediators of the expectation‐outcome link and patient factors that relate to their outcome expectations. Finally, we discuss limitations of the research base and offer therapeutic practices based on our findings. © 2010 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:184–192, 2011.
Working to make it work: the role of parents in the youth mentoring process
Authors: Spencer Renée , Basualdo‐Delmonico Antoinette , Lewis Terrence O. 
Published: December 2010

AbstractTheoretical and empirical work on youth mentoring relationships has been largely focused on the mentor‐youth dyad, with little attention to the larger context within which such relationships form and develop. The perspectives of parents have been absent for the most part from the mentoring literature to date. In‐depth, semistructured, qualitative interviews were conducted with parents (n=13) of youth who were participating in a community‐based mentoring program. Four major themes were identified: parents' (a) hopes and expectations for the mentoring relationship, (b) trust in the mentor and satisfaction with the relationship, (c) roles in the mentoring relationship, and (d) reflections on and experiences with cultural differences between their child and the mentor. © 2010 Wiley Periodicals, Inc.
Associations between mothers' experience with the troubles in Northern Ireland and mothers' and children's psychological functioning: the moderating role of social identity
Authors: Merrilees Christine E. , Cairns Ed , Goeke‐Morey Marcie C. , Schermerhorn Alice C. , Shirlow Peter , Cummings E. Mark 
Published: December 2010

AbstractRelatively little research has examined the relations between growing up in a community with a history of protracted violent political conflict and subsequent generations' well‐being. The current article examines relations between mothers' self‐report of the impact that the historical political violence in Northern Ireland (known as the Troubles) has on her and her child's current mental health. These relations are framed within the social identity model of stress, which provides a framework for understanding coping responses within societies that have experienced intergroup conflict. Mother‐child dyads (N=695) living in Belfast completed interviews. Results suggest that the mother‐reported impact of the Troubles continue to be associated with mothers' mental health, which, in turn, is associated with her child's adjustment. The strength of mothers' social identity moderated pathways between the impact of the Troubles and her mental health, consistent with the social identity model of stress. © 2010 Wiley Periodicals, Inc.
Social capital and community participation among migrant workers in China
Authors: Palmer Neal A. , Perkins Douglas D. , Xu Qingwen 
Published: December 2010

AbstractIn China, rapid development has prompted massive migration from rural to urban areas. Migrants' participation in Urban Residents Committees (URCs) and other community organizations offers opportunities for the development of social capital and democracy in contemporary China. We use 2006 survey data from a stratified convenience sample of 3,024 migrant workers in 7 Chinese cities to examine individual and community social capital and their relation to 3 types of community participation: (a) amount of contact with community organizations, (b) frequency of help sought from community organizations, and (c) the rate of participation in URC meetings. Multiple regressions yield, among 12 measures of individual and community‐focused social capital, only neighborhood interaction and organizational social capital as consistently and significantly associated for all 3 types of participation. Other measures were associated with certain types of participation, or were nonsignificant. Implications for migration policy, community participation, and social capital in China are discussed. © 2010 Wiley Periodicals, Inc.
Competing hypotheses analyses of the associations between group task conflict and group relationship conflict
Authors: Choi Kyoosang , Cho Bongsoon 
Published: December 2010

AbstractAlthough previous research have reported strong and positive intercorrelations between group task conflict and group relationship conflict, several different theoretical rationales exist for the positive link and the empirical literature remains equivocal. To clarify the causal linkage between the two types of conflict, we derived seven models specifying how group task and relationship conflict can be related to each other, including some rival explanations. We tested the competing models using a longitudinal panel design, with data collected from 74 project teams comprising a total of 388 students. The results indicated that relationship conflict led to an increased subsequent task conflict through negative group affect. Task conflict, however, predicted a subsequent relationship conflict under a specific context, that is, groups that had lower levels of trust among the members. Copyright © 2010 John Wiley & Sons, Ltd.
Proteome profile of zebrafish caudal fin based on one‐dimensional gel electrophoresis LCMS/MS and two‐dimensional gel electrophoresis MALDI MS/MS analysis
Authors: Singh Sachin K. , Meena Lakshmi Mula G. , Saxena Sandeep , Swamy Cherukuvada V. Brahmendra , Idris Mohammed M. 
Published: December 2010

AbstractZebrafish (Danio rerio) is the widely used vertebrate model animal for understanding the complexity of development and disease process. Zebrafish has been also extensively used in understanding the mechanism of regeneration for its extensive capability of regenerating fins and other tissues. We have analyzed the proteome profile of zebrafish caudal fin in its native state based on one‐dimensional gel electrophoresis LCMS/MS and two‐dimensional gel electrophoresis MS/MS analyses. A total of 417 proteins were identified as zebrafish fin tissue specific, which includes 397 proteins identified based on one‐dimensional gel electrophoresis LCMS/MS analysis and 101 proteins identified based on two‐dimensional gel electrophoresis MALDI MS/MS. The proteins mapped to the zebrafish fin tissue were shown to be involved in various biological activities related to development, apoptosis, signaling and metabolic process. Focal adhesion, regulation of actin cytoskeleton, cancer‐related pathways, mitogen‐activated protein kinase signaling, antigen processing and presentation, and proteasome are some of the important pathways associated with the identified proteome data set of the zebrafish fin.
Reconstruction of the second metacarpal bone with a free vascularized scapular bone flap combined with nonvascularized free osteocartilagineous grafts from both second toes: A case report
Authors: Jaminet Patrick , Pfau Matthias , Greulich Michael 
Published: November 2010

AbstractIn this report, we present a case of a giant cell tumor of the second metacarpal bone. The tumor was treated by en bloc resection of the distal portion of the second metacarpal with adjacent interosseus muscle. Reconstruction was achieved using a free vascularized scapular bone flap with nonvascularized free osteocartilagineous grafts from both second toes. Structural integrity and metacarpophalangeal joint motion were preserved with good functional result. A brief review of literature is presented. © 2010 Wiley‐Liss, Inc. Microsurgery, 2011.
Validation of VASO cerebral blood volume measurement with positron emission tomography
Authors: Uh Jinsoo , Lin Ai‐Ling , Lee Kihak , Liu Peiying , Fox Peter , Lu Hanzhang 
Published: December 2010

AbstractCerebral blood volume (CBV) has been shown to be an important biomarker in a number of neurological disorders and in the quantitative interpretation of functional MRI. One approach to determine CBV in humans is vascular‐space‐occupancy MRI, and this technique has been applied to the studies of brain glioma, Schizophrenia, and Alzheimer's disease. However, validation of this technique with a gold standard method has not been reported. In this study, we compared vascular‐space‐occupancy MRI with a radiotracer‐based positron emission tomography technique in a group of healthy subjects. It was found that regional CBV measured with vascular‐space‐occupancy MRI was highly correlated with that of the positron emission tomography data (R = 0.79 ± 0.10, N = 8). Furthermore, absolute CBV values quantified by vascular‐space‐occupancy were also in excellent agreement with those by positron emission tomography (slope = 1.00 ± 0.15). Because of the differences in the labeling principles between the two modalities, systematic CBV differences were observed in large vessel and ventricle regions. Magn Reson Med, 2011. © 2010 Wiley‐Liss, Inc.
Discussing the definition of the second‐order work for unsaturated soils
Authors: Buscarnera Giuseppe , Prisco Claudio di 
Published: December 2010

AbstractThe volumetric compaction due to wetting processes is a phenomenon observed quite often in unsaturated soils. Under certain circumstances, saturation events can result into a sudden and unexpected collapse of the system. These phenomena are usually referred to as wetting‐induced collapses, without providing any detailed theoretical justification for this terminology. In order to predict in a general fashion the occurrence of coupled instabilities induced by saturation processes, a generalization of the theoretical approaches usually employed for saturated geomaterials is here provided. More specifically, this paper addresses the problem of hydro‐mechanical instability in unsaturated soils from an energy standpoint. For this purpose, an extension of the definition of the second‐order work is here suggested for the case of unsaturated porous media. On the basis of some examples of numerical simulations of laboratory tests, coupled hydro‐mechanical instabilities are then interpreted in the light of this second‐order energy measure. Finally, the implications of the theoretical results here presented are commented from a constitutive modelling perspective. Two possible alternative approaches to formulate incremental coupled constitutive relations are indeed discussed, showing how the onset of hydro‐mechanical instabilities can be predicted using an extended form of Hill's stability criterion. Copyright © 2010 John Wiley & Sons, Ltd.
Cytotoxicity, drug combinability, and biological correlates of ABT‐737 against acute lymphoblastic leukemia cells with MLL rearrangement
Authors: Jayanthan Aarthi , Incoronato Andrea , Singh Anjali , Blackmore Christopher , Bernoux Delphine , Lewis Victor , Stam Ronald , Whitlock James. A. , Narendran Aru 
Published: November 2010

AbstractBackgroundABT‐737 is a BH3 mimetic small‐molecule inhibitor that binds with high affinity to Bcl‐2 to induce apoptosis in malignant cells and has shown promise as an effective anti‐leukemic agent in pediatric preclinical tests. This study focuses on the effects of ABT‐737 on leukemia cells with MLL rearrangement and identifies some of the biological correlates of its activity.ProcedureCells were cultured in the presence of increasing concentrations of ABT‐737 alone or in combination with other agents. After 4 days in culture, cell growth inhibition was measured by Alamar blue assay. The expression and activation of potential intracellular targets of ABT‐737 activity were determined by Western blot analysis.ResultsSignificant Bcl‐2 expression was detected in all infant leukemia cells investigated. ABT‐737 induced cell death in all cell lines studied although the IC50 values differed somewhat between cell lines. Western blot analysis identified the effects of ABT‐737 on survival and apoptosis‐regulatory proteins PARP, caspase‐8, and cytochrome‐c. Drug combination studies indicated synergy with distinct anti‐neoplastic agents, including the multi‐tyrosine kinase inhibitor sunitinib. This effective drug synergy appears to be mediated by the combined inhibition of Bcl‐2 and intracellular signaling pathways.ConclusionsWe describe the in vitro studies to demonstrate the activity and drug combinability of ABT‐737 against MLL rearranged leukemia cells. In addition, identification of the molecular changes that occur in the presence of ABT‐737 provides information regarding effective target validation and target modulation analyses in future clinical trials. Pediatr Blood Cancer 2011;56:353–360. © 2010 Wiley‐Liss, Inc.
Neurocognitive deficits in children with sickle cell disease are associated with the severity of anemia
Authors: Hijmans Channa T. , Grootenhuis Martha A. , Oosterlaan Jaap , Heijboer Harriët , Peters Marjolein , Fijnvandraat Karin 
Published: December 2010

AbstractBackgroundAlthough neurocognitive deficits in children with sickle cell disease (SCD) have been well documented, the etiology of these deficits has not been completely clarified. The aim of this study was to investigate the association of laboratory markers of disease severity and radiological parameters with neurocognitive functioning in children with SCD.Design and MethodsParticipants were 37 children with SCD ((HbSS or HbS‐β0‐thalassemia) aged 6–18 years. All participants underwent extensive neurocognitive assessment. Further data (TCD values, laboratory test results, and MRI data) were obtained from medical charts. Associations were analyzed by hierarchical regression analysis.ResultsHemoglobin was associated with a decrease in verbal short‐term memory. There was no association between TCD velocities and neurocognitive functioning, when controlled for age. Children with silent infarcts did not differ from children with normal MRI in neurocognitive functioning. Children with right–left asymmetries in cerebral blood flow as measured by continuous arterial spin labelling (CASL) MRI had better sustained attention than children without asymmetries.ConclusionsNeurocognitive deficits are associated with the severity of anemia, indicating reduced oxygen delivery to the brain as an etiological mechanism. This implies that children with SCD and normal MRIs may still suffer from neurocognitive impairments, possibly affecting their academic development and full participation in society. Pediatr Blood Cancer 2011; 57: 297–302. © 2010 Wiley‐Liss, Inc.
Critical review of controversial issues in the management of advanced pediatric liver tumors
Authors: Gupta Abha A. , Gerstle J. Ted , Ng Vicky , Wong Ansely , Fecteau Annie , Malogolowkin Marcio H. , Meyers Rebecka L. , Grant David , Grant Ronald M. 
Published: December 2010

AbstractHepatocellular carcinoma (HCC) and hepatoblastoma (HB) are the most common primary tumors of liver in children. The management of patients with locally advanced, unresectable disease or those with extra‐hepatic distant metastases provides substantial challenges to pediatric oncologists, hepatologists, and surgeons. Herein, we critically debate the two sides of three specific controversies: (1) the role of chemotherapy in the treatment of advanced pediatric HCC; (2) the indications for liver transplantation in children with HCC, specifically, the appropriateness of using adult Milan criteria; and (3) the role of liver trasplantation in children with unresectable HB that present with metastatic disease. Pediatr Blood Cancer 2011;56:1013–1018. © 2010 Wiley‐Liss, Inc.
Acute chest syndrome is associated with history of asthma in hemoglobin SC disease
Authors: Poulter Elana Y. , Truszkowski Piotr , Thompson Alexis A. , Liem Robert I. 
Published: November 2010

AbstractBackgroundAcute chest syndrome (ACS) is a frequent cause of morbidity and leading cause of death among individuals with sickle cell disease. Yet, ACS in hemoglobin SC disease is not well characterized. The objective of this study was to compare the presentation and clinical course of ACS in individuals with hemoglobin SC disease to that observed in individuals with hemoglobin SS disease.ProcedureWe retrospectively reviewed 71 inpatient episodes of ACS in patients with hemoglobin SC disease over a 20‐year period. Continuous and categorical data from index cases were compared with that from 71 control cases of ACS in patients with hemoglobin SS disease.ResultsMedian length of hospitalization was shorter for hemoglobin SC episodes when compared to hemoglobin SS episodes (3.0 vs. 5.0 days, P < 0.001). In comparison to hemoglobin SS patients, a greater proportion of hemoglobin SC patients had a previous history of asthma or wheezing (50.7 vs. 33.8%, OR = 2.01 [1.02–3.96], P = 0.041) and a respiratory complaint of wheeze (11.3 vs. 2.8%, OR = 4.38 [0.90–21.4], P = 0.049). In our multivariate regression model, time to ACS diagnosis and total number of days of oxygen supplementation were independent predictors of length of hospitalization in both hemoglobin SC and SS episodes of ACS.ConclusionsACS appears to be less severe in children with hemoglobin SC disease compared to that in children with SS disease. Asthma and wheezing may represent more significant risk factors for the development of ACS in children with hemoglobin SC disease. Pediatr Blood Cancer 2011; 57: 289–293. © 2010 Wiley‐Liss, Inc.