bluuebunny/crossref_metadata_2025_split huggingface dataset:
Test–retest reliability of putting-related variables in medium-to-high handicap golf players
Authors: García-Massó Xavier , Villarrasa-Sapiña Israel , Ortega-Benavent Nuria , Montalt-García Sergio , Toca-Herrera José L. 
Published: May 2024

AbstractThis manuscript aims to study the reliability of different variables related to performance and acceleration during the golf putt in players with medium-to-high handicaps and to determine the number of attempts necessary to find reliable values for these variables. Eight males and two females [55.67 (13.64) years, 78.4 (11.4) kg, 1.75 (7.95) m] participated in two experimental sessions separated by one week. In these sessions, they performed three blocks of 10 putts trying to stop the golf ball at the center of a dartboard painted 2 m away. The performance was assessed depending on the area of the dartboard where the ball stopped, and the acceleration signals were acquired using the Xsens Dot. The results showed that to evaluate performance, 18 trials were necessary to reach reliable values using the 0–10 scoring system, and 28 trials were necessary for the 0–3 scoring system. Regarding the reliability of the accelerometer-related variables, 7 attempts were necessary to obtain good-to-excellent reliability values for most of the variables. It could be concluded that putting in medium-to-high handicap golf players can be reliably measured using the abovementioned protocol.
Entanglement in photo-ionization process
Authors: Ivanov I. A. , Kim Kyung Taec 
Published: May 2024

AbstractWe report a study of the entanglement between the quantized photon field and an atom arising in the photo-ionization process. Our approach is based on an ab initio solution of the time-dependent Schrödinger equation (TDSE) describing the quantum evolution of a bipartite system consisting of the atom and the quantized electromagnetic field. Using the solution of the TDSE, we calculate the reduced photon density matrix, which we subsequently use to compute entanglement entropy. We explain some properties of the entanglement entropy and propose an approximate formula for the entanglement entropy based on the analysis of the density matrix and its eigenvalues. We present the results of a comparative study of the entanglement in the photo-ionization process for various ionization regimes, including the tunneling and the multiphoton ionization regimes.
Adverse event signal mining and serious adverse event influencing factor analysis of fulvestrant based on FAERS database
Authors: Yin Guisen , Song Guiling , Xue Shuyi , Liu Fen 
Published: May 2024

AbstractFulvestrant, as the first selective estrogen receptor degrader, is widely used in the endocrine treatment of breast cancer. However, in the real world, there is a lack of relevant reports on adverse reaction data mining for fulvestrant. To perform data mining on adverse events (AEs) associated with fulvestrant and explore the risk factors contributing to severe AEs, providing a reference for the rational use of fulvestrant in clinical practice. Retrieved adverse event report information associated with fulvestrant from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database, covering the period from market introduction to September 30, 2023. Suspicious AEs were screened using the reporting odds ratio (ROR) and proportional reporting ratio methods based on disproportionality analysis. Univariate and multivariate logistic regression analyses were conducted on severe AEs to explore the risk factors associated with fulvestrant-induced severe AEs. A total of 6947 reports related to AEs associated with fulvestrant were obtained, including 5924 reports of severe AEs and 1023 reports of non-severe AEs. Using the disproportionality analysis method, a total of 210 valid AEs were identified for fulvestrant, with 45 AEs (21.43%) not listed in the product labeling, involving 11 systems and organs. The AEs associated with fulvestrant were sorted by frequency of occurrence, with neutropenia (325 cases) having the highest number of reports. By signal strength, injection site pruritus showed the strongest signal (ROR = 658.43). The results of the logistic regression analysis showed that concurrent use of medications with extremely high protein binding (≥ 98%) is an independent risk factor for severe AEs associated with fulvestrant. Age served as a protective factor for fulvestrant-related AEs. The co-administration of fulvestrant with CYP3A4 enzyme inhibitors did not show statistically significant correlation with the occurrence of severe AEs. Co-administration of drugs with extremely high protein binding (≥ 98%) may increase the risk of severe adverse reactions of fulvestrant. Meanwhile, age (60–74 years) may reduce the risk of severe AEs of fulvestrant. However, further clinical research is still needed to explore and verify whether there is interaction between fulvestrant and drugs with high protein binding through more clinical studies.
A compact tri-notched flexible UWB antenna based on an inkjet-printable and plasma-activated silver nano ink
Authors: Yang Wendong , Zhao Xun , Guo Zihao , Sun Haoqiang , List-Kratochvil Emil J. W. 
Published: May 2024

AbstractThe rapid development of ultrawideband (UWB) communication systems has resulted in increasing performance requirements for the antenna system. In addition to a wide bandwidth, fast propagation rates and compact dimensions, flexibility, wearability or portability are also desirable for UWB antennas, as are excellent notch characteristics. Although progress has been made in the development of flexible/wearable antennas desired notch properties are still rather limited. Moreover, most presently available flexible UWB antennas are fabricated using environmentally not attractive subtractive etching-based processes. The usage of facile additive sustainably inkjet printing processes also utilizing low temperature plasma-activated conductive inks is rarely reported. In addition, the currently used tri-notched flexible UWB antenna designs have a relatively large footprint, which poses difficulties when integrated into miniaturized and compact communication devices. In this work, a silver nano ink is used to fabricate the antenna via inkjet printing and an efficient plasma sintering procedure. For the targeted UWB applications miniaturized tri-notched flexible antenna is realized on a flexible polyethylene terephthalate (PET) substrate with a compact size of 17.6 mm × 16 mm × 0.12 mm. The antenna operates in the UWB frequency band (2.9–10.61 GHz), and can shield interferences from WiMAX (3.3–3.6 GHz), WLAN (5.150–5.825 GHz) and X-uplink (7.9–8.4 GHz) bands, as well as exhibits a certain of bendability. Three nested "C" slots of different sizes were adopted to achieve notch features. The simulation and test results demonstrate that the proposed antenna can generate signal radiation in the desired UWB frequency band while retaining the desired notch properties and having acceptable SAR values on-body, making it a viable candidate for usage in flexible or wearable communication transmission devices. The research provides a facile and highly efficient method for fabricating flexible/wearable UWB antennas, that is, the effective combination of inkjet printing processing, flexible substrates, low temperature-activated conductive ink and antenna structure design.
Elucidating the underlying components of metacognitive systematic bias in the human dorsolateral prefrontal cortex and inferior parietal cortex
Authors: Cong Peiyao , Long Yiting , Zhang Xiaojing , Guo Yanlin , Jiang Yingjie 
Published: May 2024

AbstractMetacognitive systematic bias impairs human learning efficiency, which is characterized by the inconsistency between predicted and actual memory performance. However, the underlying mechanism of metacognitive systematic bias remains unclear in existing studies. In this study, we utilized judgments of learning task in human participants to compare the neural mechanism difference in metacognitive systematic bias. Participants encoded words in fMRI sessions that would be tested later. Immediately after encoding each item, participants predicted how likely they would remember it. Multivariate analyses on fMRI data demonstrated that working memory and uncertainty decisions are represented in patterns of neural activity in metacognitive systematic bias. The available information participants used led to overestimated bias and underestimated bias. Effective connectivity analyses further indicate that information about the metacognitive systematic bias is represented in the dorsolateral prefrontal cortex and inferior parietal cortex. Different neural patterns were found underlying overestimated bias and underestimated bias. Specifically, connectivity regions with the dorsolateral prefrontal cortex, anterior cingulate cortex, and supramarginal gyrus form overestimated bias, while less regional connectivity forms underestimated bias. These findings provide a mechanistic account for the construction of metacognitive systematic bias.
Subclinical structural atypicality of retinal thickness and its association with gray matter volume in the visual cortex of maltreated children
Authors: Yao Akiko , Nishitani Shota , Yamada Yutaka , Oshima Hideyuki , Sugihara Yuka , Makita Kai , Takiguchi Shinichiro , Kawata Natasha Y. S. , Fujisawa Takashi X. , Okazawa Hidehiko , Inatani Masaru , Tomoda Akemi 
Published: May 2024

AbstractChildhood maltreatment is reportedly associated with atypical gray matter structures in the primary visual cortex (V1). This study explores the hypothesis that retinal structures, the sensory organs of vision, are associated with brain atypicality and child maltreatment and examines their interrelation. General ophthalmologic examinations, visual cognitive tasks, retinal imaging, and structural magnetic resonance imaging (MRI) were conducted in children and adolescents aged 9–18 years with maltreatment experiences (CM) and typically developing (TD) children. The retinal nerve fiber layer (RNFL), the most superficial of the ten distinct retinal layers, was found to be significantly thinner in both eyes in CM. While whole-brain analysis using Voxel-based morphometry revealed a significantly larger gray matter volume (GMV) in the thalamus in CM, no significant correlation with RNFL thickness was observed. However, based on region-of-interest analysis, a thinner RNFL was associated with a larger GMV in the right V1. Although it cannot be ruled out that this outcome resulted from maltreatment alone, CM demonstrated subclinical structural atypicality in the retina, which may also correlate with the immaturity of V1 development. Examination of retinal thickness offers a novel clinical approach to capturing characteristics associated with childhood maltreatment.
Ballistic analysis of high-performance armor steel by numerical simulation
Authors: Li Deda , Huang Feng , Ren Binzhi , Zhang Wei , Xiong Junjie , Zhou Binjun , Guo Xun 
Published: May 2024

AbstractIn order to establish a connection between the ballistic performance and mechanical properties of armor steel, a ballistic simulation model was developed and subsequently validated for accuracy and reliability. The mechanical properties of the target plate were described using the Johnson–Cook constitutive relation. An analysis was conducted to investigate the impact of the J–C parameters of the target plate on its ballistic performance, revealing a strong linear relationship between them. Subsequently, a mathematical model represented as H = 14.82 − 0.0048A − 0.0023B + 5.95n − 81.3C was derived, and its accuracy was demonstrated to exceed 90%. This mathematical model can effectively predict the ballistic performance of the armor steel, even when its mechanical properties undergo variations during the production process. This prediction capability significantly contributes to reducing research costs and time.
Effect of cytokines on advanced hepatocellular carcinoma prognosis receiving radiotherapy and tislelizumab plus anlotinib: a single-center phase II clinical trial
Authors: Lin Yi Dong , Wu Gui Shu , Rao Ming Yue , Liu Yu Hong , Han Yun Wei , Zhang Jing , Zhang Jian Wen 
Published: May 2024

AbstractThe purpose of this study was to investigate the relationship between circulating cytokines and liver function and prognosis of patients with advanced hepatocellular carcinoma (HCC) treated with radiotherapy combined with tislelizumab and anlotinib. The liver function indexes and pre-treatment levels of cytokines in 47 patients were measured by chemical method and flow cytometry. The median follow-up was 23.1 months. The objective response and the disease control rates were 46.8% and 68.1%, while overall survival (OS) and progression-free survival (PFS) were 12.6 and 11.4 months, respectively. Adverse events (2.1%) were grade 3–4. In addition to stage, intrahepatic metastasis and Child–Pugh score, pre-treatment interleukin-6 (IL-6) was the main cytokine affecting OS and PFS (p < 0.05). The OS (14.63 pg/mL as cutoff value) and PFS (9.85 pg/mL as cutoff value) of patients with low IL-6 levels exceeded those with high levels (21.0 and 6.9, 15.8 and 10.0 months, respectively). The risks of death and disease progression were reduced by 63.0% (HR = 0.37, 95% CI: 0.19–0.72) and 43.0% (HR = 0.57, 95% CI: 0.22–1.47), respectively. Pre-treatment IL-6 levels may be a simple and effective prognostic indicator for patients with advanced HCC treated with radiotherapy combined with immunotargeted therapy.
Redirecting NK cells to the lymph nodes to augment their lymphoma-targeting capacity
Authors: Sanz-Ortega Laura , Leijonhufvud Caroline , Schoutens Lisanne , Lambert Mélanie , Levy Emily , Andersson Agneta , Wahlin Björn E. , Carlsten Mattias 
Published: May 2024

AbstractCAR-NK cells can induce remission in lymphoma patients. We speculate that the full potential of adoptive NK cell immunotherapy against lymphoma is restricted by their poor lymph node (LN) homing capacity. Here, we have utilized a clinically approved transfection method with the aim of redirecting NK cells to LNs. Electroporation of ex vivo expanded NK cells with mRNAs coding for CCR7, CXCR5, and CD62L resulted in increased in vitro migration towards chemokines and mouse LN-derived supernatant. Following infusion into SCID/Beige mice, modified NK cells showed enhanced LN homing. Importantly, lymphoma patient-derived NK cells were equally well expanded and engineered as healthy donor NK cells, highlighting their translational potential. Additionally, the introduction of high-affinity CD16, together with the homing molecules, also augmented their ADCC capacity against autologous lymphoma cells. Hence, genetic engineering can be utilized to enhance NK cell LN homing. The homing concept may synergize with CAR- or monoclonal/bi-/tri-specific antibody-based approaches.
Development and validation of machine learning algorithms based on electrocardiograms for cardiovascular diagnoses at the population level
Authors: Kalmady Sunil Vasu , Salimi Amir , Sun Weijie , Sepehrvand Nariman , Nademi Yousef , Bainey Kevin , Ezekowitz Justin , Hindle Abram , McAlister Finlay , Greiner Russel , Sandhu Roopinder , Kaul Padma 
Published: May 2024

AbstractArtificial intelligence-enabled electrocardiogram (ECG) algorithms are gaining prominence for the early detection of cardiovascular (CV) conditions, including those not traditionally associated with conventional ECG measures or expert interpretation. This study develops and validates such models for simultaneous prediction of 15 different common CV diagnoses at the population level. We conducted a retrospective study that included 1,605,268 ECGs of 244,077 adult patients presenting to 84 emergency departments or hospitals, who underwent at least one 12-lead ECG from February 2007 to April 2020 in Alberta, Canada, and considered 15 CV diagnoses, as identified by International Classification of Diseases, 10th revision (ICD-10) codes: atrial fibrillation (AF), supraventricular tachycardia (SVT), ventricular tachycardia (VT), cardiac arrest (CA), atrioventricular block (AVB), unstable angina (UA), ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), pulmonary embolism (PE), hypertrophic cardiomyopathy (HCM), aortic stenosis (AS), mitral valve prolapse (MVP), mitral valve stenosis (MS), pulmonary hypertension (PHTN), and heart failure (HF). We employed ResNet-based deep learning (DL) using ECG tracings and extreme gradient boosting (XGB) using ECG measurements. When evaluated on the first ECGs per episode of 97,631 holdout patients, the DL models had an area under the receiver operating characteristic curve (AUROC) of <80% for 3 CV conditions (PTE, SVT, UA), 80–90% for 8 CV conditions (CA, NSTEMI, VT, MVP, PHTN, AS, AF, HF) and an AUROC > 90% for 4 diagnoses (AVB, HCM, MS, STEMI). DL models outperformed XGB models with about 5% higher AUROC on average. Overall, ECG-based prediction models demonstrated good-to-excellent prediction performance in diagnosing common CV conditions.
Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea
Authors: Lin Wei-Ching , Macić Anes , Becker Jonathan , Nam Jong-Hoon 
Published: May 2024

AbstractPending questions regarding cochlear amplification and tuning are hinged upon the organ of Corti (OoC) active mechanics: how outer hair cells modulate OoC vibrations. Our knowledge regarding OoC mechanics has advanced over the past decade thanks to the application of tomographic vibrometry. However, recent data from live cochlea experiments often led to diverging interpretations due to complicated interaction between passive and active responses, lack of image resolution in vibrometry, and ambiguous measurement angles. We present motion measurements and analyses of the OoC sub-components at the close-to-true cross-section, measured from acutely excised gerbil cochleae. Specifically, we focused on the vibrating patterns of the reticular lamina, the outer pillar cell, and the basilar membrane because they form a structural frame encasing active outer hair cells. For passive transmission, the OoC frame serves as a rigid truss. In contrast, motile outer hair cells exploit their frame structures to deflect the upper compartment of the OoC while minimally disturbing its bottom side (basilar membrane). Such asymmetric OoC vibrations due to outer hair cell motility explain how recent observations deviate from the classical cochlear amplification theory.
GDE5/Gpcpd1 activity determines phosphatidylcholine composition in skeletal muscle and regulates contractile force in mice
Authors: Aisyah Rahmawati , Ohshima Noriyasu , Watanabe Daiki , Nakagawa Yoshiko , Sakuma Tetsushi , Nitschke Felix , Nakamura Minako , Sato Koji , Nakahata Kaori , Yokoyama Chihiro , Marchioni Charlotte R. , Kumrungsee Thanutchaporn , Shimizu Takahiko , Sotomaru Yusuke , Takeo Toru , Nakagata Naomi , Izumi Takashi , Miura Shinji , Minassian Berge A. , Yamamoto Takashi , Wada Masanobu , Yanaka Noriyuki 
Published: May 2024

AbstractGlycerophosphocholine (GPC) is an important precursor for intracellular choline supply in phosphatidylcholine (PC) metabolism. GDE5/Gpcpd1 hydrolyzes GPC into choline and glycerol 3-phosphate; this study aimed to elucidate its physiological function in vivo. Heterozygous whole-body GDE5-deficient mice reveal a significant GPC accumulation across tissues, while homozygous whole-body knockout results in embryonic lethality. Skeletal muscle-specific GDE5 deletion (Gde5 skKO) exhibits reduced passive force and improved fatigue resistance in electrically stimulated gastrocnemius muscles in vivo. GDE5 deficiency also results in higher glycolytic metabolites and glycogen levels, and glycerophospholipids alteration, including reduced levels of phospholipids that bind polyunsaturated fatty acids (PUFAs), such as DHA. Interestingly, this PC fatty acid compositional change is similar to that observed in skeletal muscles of denervated and Duchenne muscular dystrophy mouse models. These are accompanied by decrease of GDE5 expression, suggesting a regulatory role of GDE5 activity for glycerophospholipid profiles. Furthermore, a DHA-rich diet enhances contractile force and lowers fatigue resistance, suggesting a functional relationship between PC fatty acid composition and muscle function. Finally, skinned fiber experiments show that GDE5 loss increases the probability of the ryanodine receptor opening and lowers the maximum Ca2+-activated force. Collectively, GDE5 activity plays roles in PC and glucose/glycogen metabolism in skeletal muscle.
Anthropogenic and atmospheric variability intensifies flash drought episodes in South Asia
Authors: Ullah Irfan , Mukherjee Sourav , Syed Sidra , Mishra Ashok Kumar , Ayugi Brian Odhiambo , Aadhar Saran 
Published: May 2024

AbstractFlash droughts are abrupt and rapid intensification of droughts that affect agriculture, water, and ecosystems and are commonplace in South Asia. Despite their potential impact, flash drought evolution characteristics and underlying mechanisms in South Asia remain underexplored. We use a multivariate approach to analyze the onset speed, frequency, severity, duration, and return period of flash droughts, and the role of atmospheric circulation and human-induced climate change. We find that flash droughts are more common and intense in the crop season, especially in central India, western Pakistan, and eastern Afghanistan. They are caused by persistent atmospheric patterns that block moisture transport to South Asia. Additionally, anthropogenic climate change has intensified flash droughts in the spring-summer season, with a median fraction of attributable risk of 60%, 80%, and 90% for Afghanistan, Pakistan, and India, respectively. Our results suggest that flash droughts will expand and worsen in the future, requiring adaptation measures for the water, agriculture, and energy sectors.
A secured cloud‐medical data sharing with A‐BRSA and Salp ‐Ant Lion Optimisation Algorithm
Authors: Binbusayyis Adel , Alanazi Abed , Alsubai Shtwai , Alasiry Areej , Marzougui Mehrez , Alqahtani Abdullah , Sha Mohemmed , Aslam Muhammad 
Published: May 2024

AbstractSharing medical data among healthcare providers, researchers, and patients is crucial for efficient healthcare services. Cloud‐assisted smart healthcare (s‐healthcare) systems have made it easier to store EHRs effectively. However, the traditional encryption algorithms used to secure this data can be vulnerable to attacks if the encryption key is compromised, posing a security threat. A secured cloud‐based medical data‐sharing system is proposed using a hybrid encryption model called A‐BRSA, which combines attribute‐based encryption (ABE) and B‐RSA encryption. The system utilises the Salp‐Ant Lion Optimisation Algorithm for optimal key selection. The encrypted data is stored in the cloud and transmitted to the recipient, where it is decrypted using A‐BRSA‐based decryption. The study measures turnaround time, encryption time, decryption time, and restoration efficiency to evaluate the system's performance. The results demonstrate the effectiveness of the A‐BRSA model in ensuring secure medical data sharing in cloud‐based s‐healthcare systems.