bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’atelier d’Étienne-Maurice Falconet à Saint-Pétersbourg : lieu de rencontres dans la Russie de Catherine II
Authors: Tardy Hugo 
Published: May 2024

L’atelier du sculpteur Étienne-Maurice Falconet à Saint-Pétersbourg est connu pour avoir été le lieu de création de la célèbre Statue équestre de Pierre le Grand, commandée par Catherine II. Réaliser une étude en passant par le lieu, comme lieu de rencontre, apporte, dans le cas de l’atelier, un nouveau regard sur un sujet qui reste encore à exploiter. Cela permet, entre autres, d’enrichir notre compréhension de la sociabilité d’un sculpteur parisien à Saint-Pétersbourg, ainsi que d’examiner l’émergence de l’intérêt des Russes pour l’art de la sculpture.
Le grand domaine agricole, un centre diffus mais symbolique du pouvoir en Prusse-Orientale (1815-1914)
Authors: Ferrebeuf Florian 
Published: May 2024

Le grand domaine agricole constitue, en Prusse-Orientale, une cellule sociale fondamentale dans laquelle toutes les composantes de la société sont représentées. Le grand domaine agricole est avant tout un lieu de production agricole, où le seigneur propriétaire emploie des paysans de statuts différents pour travailler ses terres. La modernisation des domaines s’accélère au cours du siècle, pour accroître les rendements et permettre l’enrichissement de son propriétaire. Les paysans vivent parfois directement dans un domaine agricole au statut législatif particulier (Gutsbezirk), puisque le propriétaire a encore un pouvoir contraignant sur ses subalternes. La paysannerie essaie pourtant de surmonter la domination seigneuriale à travers des processus de singularisation. Ainsi, le grand domaine agricole est aussi un lieu de rencontre au niveau politique. Dans une province où près de 60 % de la population vit de l’agriculture dans les années 1890, le grand propriétaire possède effectivement une influence politique certaine.
L’espace éphémère de la performance incantatoire, lieu de rencontre entre les mondes
Authors: Moine Aleksi 
Published: May 2024

Il était courant dans la Carélie du XIXe siècle d’utiliser des incantations pour assurer le bien-être des individus et de la communauté en communiquant avec des agents non humains. La performance incantatoire pouvait avoir lieu dans le sauna, notamment pour les rituels de guérison, ou dans la forêt, par exemple dans les rituels liés à la chasse ou à la protection du bétail. Si la plupart des incantations conservées le sont sous forme textuelle, l’énonciation a laissé dans les textes des traces du cadre spatio-temporel de la performance. J’étudie dans cet article la manière dont le sauna et la forêt sont construits comme espaces de la performance incantatoire. C’est à travers une perspective corporelle que les deux lieux se construisent et proposent une rencontre entre les dimensions humaine et non humaine de l’univers.
L’alimentation à Nuuk, miroir d’un « anti-Groenland » en quête de centralité culturelle
Authors: Parmantier Nina 
Published: May 2024

Tandis que Nuuk est souvent considérée comme ne faisant pas partie du « vrai Groenland », l’article questionne l’identité groenlandaise sous le prisme de l’alimentation et de la possibilité pour Nuuk d’acquérir une centralité culturelle via des pratiques alimentaires communes aux Nuukois au-delà de leur origine. L’article dépasse l’opposition entre autochtonie et allochtonie et cherche à souligner au contraire le lien culturel que représentent les pratiques alimentaires à Nuuk. L’enjeu réside dans un premier temps à analyser les dynamiques propres à l’identité alimentaire nuukoise et le décalage qui peut exister entre la capitale et le reste du Groenland. Cette divergence est remise en question par les stratégies de transmission et d’adaptation du patrimoine alimentaire qui conduisent à la réaffirmation de la centralité culturelle de Nuuk au Groenland. L’émergence d’une identité inclusive dans la capitale multiculturelle favorise-t-elle alors la construction d’un vivre-ensemble qui dépasse les oppositions ethniques qui peuvent subsister au Groenland ?
Confusional Arousal: Two Case Reports
Authors: Fatma Farheen , Karia Sagar , Shah Nilesh , Desousa Avinash 
Published: May 2024

Abstract
Confusional arousal, classified under parasomnias, is a condition in which patients exhibit wakeful behaviors while still apparently asleep. It may be associated with shouting or sleepwalking and usually lasts for a few minutes to several hours. Patients tend to have no memory of the occurrence of such episodes. We report two cases of confusional arousals, the first, a 15-year-old boy suffering from autism spectrum disorder, and the second, a 10-year-old boy, with no other significant history.
Role of Expressed Emotions and Its Impact on Relapse in Bipolar Affective Disorder
Authors: Endreddy Ananda Reddy , Ch Lakshmi Rajesh , Veeramachaneni Harshitha 
Published: May 2024

Abstract

Background:
The role of expressed emotions (EEs) in relapse is poorly understood in bipolar affective disorder (BPAD). Understanding the association between EE and relapse will be useful in predicting further relapse and improving the prognosis.

Aims and Objectives:
The present study was conducted with the objectives of assessing the relationship between EEs of caregivers and relapse of the illness in patients with BPAD on regular medication and to assess the relationship between severity of illness and EEs.

Materials and Methods:
Fifty consecutive bipolar disorder patients diagnosed as per the International Classification of Diseases-10 criteria, who were admitted into the department of psychiatry with relapse while on regular medication, and their caregivers were recruited into the study. Data were collected using a semi-structured pro forma designed for the study. Clinical details of illness were obtained from the informant and the records. The severity of the current episode was assessed with the rating scales (Young Mania Rating Scale and Hamilton Depression Rating Scale). The Expressed emotions(EE) among the caregivers were assessed using the Family Attitude Scale, association between EE and relapses as well as the severity of illness was analyzed with appropriate tests.

Results:
The mean age of the patients was 43.8 ± 15.4. Majority of them were male and married (68% and 68%). The mean age of the caregivers was 47.1 ± 10.5. The majority of the caregivers were female (60%). Sixty-four percent of the caregivers had high EEs. The mean age of onset of illness was 26.2 ± 4.6, and the number of previous episodes was 3.9 ± 2.5. The total duration of illness was 17.7 ± 13.4 years, and the number of previous admissions was 3.3 ± 2.2. Among clinical variables of patients and caregivers with high EEs, a significant association was found between duration of illness (Chi-square test: 11.82, P = 0.003), previous episodes (Chi-square test: 12.26, P < 0.01), and the number of previous admissions (Chi-square test: 9.79, P = 0.002).

Conclusion:
There was a significant association between high EE and relapse.
Sociodemographic Predictors of Care Burden and Psychological Distress in Schizophrenia
Authors: Singh Abhijeet 
Published: May 2024

Abstract

Background:
Caregiving is schizophrenia is challenging and burdensome.

Aim and Objectives:
The study aimed to know the sociodemographic predictors of care burden and psychological distress in schizophrenia.

Materials and Methods:
The present study was a cross-sectional descriptive study. A total sample of 540 caregivers of persons with schizophrenia was selected, using purposive sampling from the outpatient Department of LGBRIMH, Tezpur, Assam. The study was approved by the IEC of LGBRIMH, Tezpur. Statistical analysis was done using SPSS version 23.0.

Results:
The mean age of patients and their caregivers was 35.6 ± 13.4 and 37.7 ± 12.4 years, respectively. Moderate to severe level of care burden was present in male caregivers (55.6%). Severe level of stress, anxiety, and depression was present in majority of the male respondents (42.5%, 43.2%, and 49.0%, respectively) who were the primary caregivers (41.2%, 40.8%, and 48.9%, respectively), married (41.2%, 37.7%, and 48.1%, respectively), belonging to rural background (43.8%, 43.2%, and 48.5%, respectively), educated till primary level (42.6%, 44.6%, and 58.3%, respectively), mostly unemployed (49.2%, 47.5%, and 50.8%, respectively) belonging to lower socioeconomic background (46.6%, 49.2%, and 48.0%, respectively), and with a history of mental illness in the family (41.6%, 40.7%, and 48.0%, respectively). Extremely severe level of stress (57.1%), with severe level of anxiety and depression (41.7%, 52.8%), was present in majority of the caregivers having nuclear family type condition. Marital status, occupation, family income, and type of caregiving contribute significantly to the prediction of care burden (F [14,525] =11.6, P = 0.001), whereas, caregiver’s gender, education, and, patient’s onset of illness contribute significantly to the prediction of psychological distress among caregivers (F [14,525] =5.31, P = 0.001).

Conclusion:
Psychosocial intervention is the need of the hour.
Internalized Stigma among Persons with Schizophrenia: A Study from Tertiary Care Center in the Northeastern Part of India
Authors: Ali Arif , Islam Sabana Nasrin , Paul Fayaz Ahmad 
Published: May 2024

Abstract

Background:
Stigma relating to mental illness has mostly been studied in communities and families. Less research has been conducted in India to understand the current subjective experience of persons with mental illness in the tertiary care hospital setting in India.

Aim and Objectives:
This study aimed to assess the extent of internalized stigma among persons and to see the association between self-stigma, self-esteem, insight, and adherence.

Methodology:
The study used a cross-sectional design. The present study was conducted in the Outpatient Department of LGB Regional Institute of Mental Health, Tezpur, Assam. For the present study, 200 persons with schizophrenia were selected. Participants of this study were persons with a clinical diagnosis of schizophrenia according to the International Classification of Diseases-10 Diagnostic Criteria for Research. Sociodemographic and clinical data sheet, Brief Psychiatric Rating Scale, the Internalized Stigma of Mental Illness Scale, Morisky Adherence Scale, and Rosenberg Self-Esteem Scale were administered. The collected data were analyzed using descriptive and inferential statistics in Statistical Package for Social Science (SPSS) 21 version.

Results:
The findings show that 45% of the participants were having moderate internalized stigma and 21% of the participants were having severe internalized stigma. Self-Esteem Scale (B = −341, t = −2.940, P = 005), medication adherence (B = −701, t = −9.832, P = 000), and insight (B = −711, t = −6.496, P = 000) contributed significantly to the prediction of internalized stigma among persons with schizophrenia (F [3,63] =58.712, P = 000) accounting for 85.8% variance.

Conclusion:
The findings confirm that self-esteem, medication adherence, and insight contributed significantly to the prediction of internalized stigma among persons with schizophrenia.
Molecular diagnostics of prostate cancer: impact of molecular tests
Authors: Azzalini Eros , Bonin Serena 
Published: May 2024

Abstract
Prostate cancer (PCa) is the second leading cause of cancer-related death among men. Prostate-specific antigen (PSA) testing is used in screening programs for early detection with a consequent reduction of PCa-specific mortality at the cost of overdiagnosis and overtreatment of the nonaggressive PCa. Recently, several assays have been commercially developed to implement PCa diagnosis, but they have not been included in both screening and diagnosis of PCa. This review aims to describe the actual and novel commercially available molecular biomarkers that can be used in PCa management to implement and tailor the screening and diagnosis of PCa.
Frequency of Transcription Factor 7-like 2 rs12255372 Mutation among Bangladeshi Adult Type 2 Diabetes Patients
Authors: Mahmood Syed Azmal , Fariduddin Mohammad , Banu Laila Anjuman , Hossain Shoaib , Masum Md Mohiuddin , Selim Shahjada 
Published: May 2024

Background:
While the etiology of type 2 diabetes mellitus (T2DM) is complex, genetic markers for T2DM are surfacing fast, and amidst such markers, the transcription factor 7-like 2 (TCF7L2) gene has been emerged as the most promising T2DM-causing gene. The intronic variant rs12255372 of the TCF7L2 gene has been found to be strongly associated with T2DM in different ethnic populations.

Objectives:
The objectives of this study were to determine the frequency of rs12255372 polymorphism in the TCF7L2 gene in Bangladeshi adult population with T2DM.

Materials and Methods:
This cross-sectional study was conducted in the Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University. Eighty T2DM patients were recruited consecutively by nonrandom sampling, who signed the informed consent, history, and clinical features including height, weight, and waist circumferences were recorded. Blood samples were collected. Genomic DNA was extracted and single-nucleotide polymorphisms rs12255372 (G>T) were determined by the restriction fragment length polymorphism (RFLP) method.

Statistical Analysis:
RFLP results were analyzed by the gel electrophoresis to get the frequency of rs12255372 polymorphism. The independent segregation of alleles was tested for Hardy–Weinberg equilibrium using the Chi-square test of goodness of fit. P ≤0.05 was considered statistically significant.

Results:
The minor (T) allele frequencies (MAF) for rs12255372 (G>T) among T2DM was 28%. The observed genotype frequencies of rs12255372 (G>T) were different than those expected from the Hardy–Weinberg equation.

Conclusion:
The minor T allele frequency of rs12255372 (G>T) among T2DM participants was about one-fourth.
Autologous Concentrate Growth Factor for the Treatment of Endo-Perio Lesion – A Case Report
Authors: Aggarwal Priyanka , Singh Vandana 
Published: May 2024

Abstract

Introduction:
The success of a combined periodontal and endodontic lesion depends on the elimination of both these disease processes. In the case of a combined endo-perio lesion, endodontic therapy results in healing of the endodontic component of involvement, while the prognosis of teeth would finally depend on the healing of the periodontal structure.

Treatment:
This case report evaluates the efficacy of autologous fibrin glue and bone graft, that is, sticky bone in the management of bone defects associated with endo-perio lesion. The endo-perio lesion is first treated endodontically, followed by periodontal therapy. Conclusion: The patient was kept on follow-up for 9 months, and satisfactory results in terms of bone fill and reduction in pocket depth were obtained.

Take-away Lessons:
The sticky bone enhances regeneration in treatment of endo-perio lesions.
Leiomyosarcoma of the esophagus, arising from lamina muscularis mucosae, in a combination with microinvasive squamous cell carcinoma—A case report
Authors: Bozhkova Desislava M. , Chapkanov Anastas P. , Koleva Maria S. 
Published: May 2024

ABSTRACT
Leiomyosarcoma of the esophagus is a very rare disease, accounting for less than 0.5% of malignant esophageal tumors. Esophageal leiomyosarcoma combined with squamous cell carcinoma is even rarer than solitary leiomyosarcoma. To our knowledge, there are less than ten cases of simultaneously diagnosed leiomyosarcoma and squamous cell carcinoma of the esophagus. A 66-year-old male was admitted to our hospital suffering from epigastric pain, asthenia, weight loss, and difficulties when feeding with solid food which had been present for 2 weeks. A computed tomography scan showed a large tumor tissue mass in the mid-to-distal part of the esophagus. The patient underwent robot-assisted surgery—an esophagectomy with esophagogastrostomy. Histologically, the tumor consisted of highly pleomorphic spindle cells with multiple atypical mitosis and necrotic areas. An immunohistochemical examination was performed to distinguish leiomyosarcoma from spindle cell squamous carcinoma or malignant GIST. Tumor cells stained diffusely positive for smooth muscle actin, but negative for p63, CD117, and CKAE1/AE3. Tumor invasion involved mucosa and submucosa, without tunica muscularis propria. Microinvasive well-differentiated squamous cell carcinoma was also noted in the mucosa at the borders between the tumor and the healthy part of the esophagus. The aim of the manuscript is to present an extremely rare case of combined polypoid leiomyosarcoma and microinvasive squamous cell carcinoma of the esophagus, cured by robot-assisted surgical intervention and to emphasize that such cases should be examined carefully, including additional diagnostic tests such as Immunohistochemistry (IHC) in order to define the correct diagnosis.
Tumor necrosis serves as an important pathological characteristic of stage I–II colon cancer
Authors: Dong Shuhui , Xu Jin , Li Mingshan , Xiong Guangyi , Wang Ruilin 
Published: May 2024

ABSTRACT

Background:
The long-term prognosis of colon cancer patients remains little changed with relatively high mortality and morbidity. Since the most widely used prognostic parameter TNM staging system is less satisfactory in predicting prognosis in early-stage cancers, numerous clinicopathological factors, including tumor necrosis, have been proposed for prognosis stratification, but substantial evidences are still lacking for early-stage colon cancer.

Materials and Methods:
In the retrospective study, a total of eligible 173 stage I–II colon cancer patients, who received tumor radical resection and lymphadenectomy in the local hospital between January 1, 2010, and December 31, 2018, were enrolled for analyzing the prognostic role of tumor necrosis. The primary endpoints included 5-year overall survival (OS) and progression-free survival (PFS).

Results:
The median follow-up of enrolled early-stage colon cancer patients was 58.3 months. The 2-year and 5-year OS rates were 88.3% and 68.2%, respectively, and the 2-year and 5-year PFS rates were 85.6% and 62.7%, respectively. Seventy-eight patients (45.1%) were diagnosed with tumor necrosis by pathological examination. Demographic analysis revealed a significant association of tumor necrosis with larger tumor size and a marginal association with vascular invasion. Kaplan–Meier survival curves demonstrated that tumor necrosis was associated with worse OS (log-rank P = 0.003) and PFS (log-rank P = 0.002). The independent unfavorable prognostic effect of tumor necrosis was further validated in univariate and multivariate Cox regression analysis (hazard ratio = 1.91 (1.52–2.40), P = 0.004).

Conclusions:
The current study confirmed the independent prognostic role of tumor necrosis from pathological review in early-stage colon cancer patients. This pathological criterion promises to help in identifying high-risk subgroup from early-stage colon cancer patients, who may benefit from strict follow-up and adjuvant therapy.
Minocycline-induced drug reaction with eosinophilia and systemic symptoms (DRESS) masquerading as acute leukemia
Authors: Gupta Devika , Singh Kanwaljeet , Dhaka Ankit , Sengupta Prasanta 
Published: May 2024

ABSTRACT
Drug reaction with eosinophilia and systemic symptoms (DRESS) is an idiosyncratic drug reaction characterized by fever, rash, and lymphadenopathy associated with atypical lymphocytosis and eosinophilia. Visceral organ involvement is also seen and hence it often mimics hematolymphoid malignancies. A 19-year-old girl presented with generalized pruritic rash, fever, lymphadenopathy, and lymphocytosis. Subsequently, she developed respiratory distress with a fall in SpO2. Flow cytometry, bone marrow studies, and infectious workup were normal. Skin biopsy and clinical assessment criteria established the diagnosis of DRESS secondary to minocycline intake. Discontinuation of the offending drug is most important to abet the hypersensitivity reaction. Visceral organ involvement requires the use of steroids and immunosuppressive agents. Our patient responded well to treatment and is presently symptom-free and on follow-up for the last 6 months.
Assessment of Lung Health Status by Analyzing Cough Sound Using Swaasa Artificial Intelligence Technology
Authors: Pavithra R , Sindhu B. M. , Kumbar Abhinandan S. , Balu P. S. , Sangolli Basavaraj , Rashmi B. M. , Gowda Nagendra , Vasudevareddy Savitha S. 
Published: May 2024

Introduction:
The crucial function of the respiratory system is the facilitation of blood gas exchange process. Spirometry is the diagnostic tool to detect and differentiate obstructive and restrictive respiratory diseases that impair this vital function. The need for a clinical setup, technical expertise, and patient compliance are certain limitations for utilizing spirometry in remote areas. Swaasa® artificial intelligence (AI) platform, which has a Class B manufacturing license from India’s Central Drugs Standard Control Organization, is a validated “software as a medical device,” which aids in screening and diagnosis of respiratory diseases, unbounded by location, equipment and technical expertise.

Objectives:
The objectives of the study were to determine the “lung health index” and the “pattern of lung health” conditions among nursing students.

Materials and Methods:
A cross-sectional study was conducted utilizing the Swaasa® AI platform among students of a nursing college in Central Karnataka in June 2023. Based on audiometric analysis of cough sounds, parameters such as underlying respiratory condition, cough count values, and respiratory symptoms experienced, ‘Swaasa’ AI platform derives pattern of respiratory condition (normal/obstructive/restrictive/mixed), ‘Lung Health Index,’ and presence or absence of lung health risk. Data collected in the Swaasa app were downloaded and analyzed using SPSS.v. 20.

Results:
Lung health risk was present in 58.2% of participants. Abnormal lung pattern was noted in 21.3% of participants (obstructive: 14.8%, restrictive: 2.5%, and mixed pattern: 4.1%).

Conclusion:
The Swaasa AI platform was utilized in this study to self-test lung health in real time without the need for a clinical setting. A high lung health index was found among 18% of participants. Studies adopting such cough sound analysis involving a larger population from wider geographic areas have to be conducted to detect and monitor respiratory diseases to increase its usage among the medical community in everyday clinical practice and also in remote areas.
To check the antibacterial efficacy against Enterococcus faecalis by various ayurvedic oils used as a solvent in endodontic sealers - An in vitro study
Authors: Kumari Manju , Arora Sharvi , Kochhar Rohit 
Published: May 2024

Aim:
The aim of the study is to check the antibacterial efficacy of various ayurvedic oils used as a solvent with zinc oxide for preparing endodontic sealers.

Materials and Methods:
Forty-five extracted premolars were taken and were cut coronally and apically such that 7 mm of tooth specimen was prepared. Teeth were sterilized by autoclaving inoculated with Enterococcus faecalis and incubated for 24 h. The specimens were divided into three groups of 15 each. Group 1 – ZnO powder + Eugenol, Group 2 – ZnO powder + Aremidadi Oil, and Group 3 – ZnO powder + Dashmool oil. Bacterial growth in each specimen was calculated before and after sealer application and noted as the initial and final colony count. The antimicrobial effect of each sealer was measured by calculating the percentage reduction in colony count (%). One-way analysis of variance and post hoc tests will be used for statistical analysis.

Results:
The Zn + Arimedadi oil group showed the maximum antibacterial effect among the sealers tested and the Zn + eugenol sealer showed the least antimicrobial effect In comparison, there was a statistically significant difference between all the groups.

Conclusion:
Ayurvedic oil-based root canal sealers showed better antibacterial efficacy than eugenol-based sealers. Arimedadi oil showed the highest antibacterial activity against E. faecalis and Eugenol showed the least when used as a solvent.