bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eighteen Insulin-like Growth Factor Pathway Genes, Circulating Levels of IGF-I and Its Binding Protein, and Risk of Prostate and Breast Cancer
Authors: Gu Fangyi , Schumacher Fredrick R. , Canzian Federico , Allen Naomi E. , Albanes Demetrius , Berg Christine D. , Berndt Sonja I. , Boeing Heiner , Bueno-de-Mesquita H. Bas , Buring Julie E. , Chabbert-Buffet Nathalie , Chanock Stephen J. , Clavel-Chapelon Françoise , Dumeaux Vanessa , Gaziano J. Michael , Giovannucci Edward L. , Haiman Christopher A. , Hankinson Susan E. , Hayes Richard B. , Henderson Brian E. , Hunter David J. , Hoover Robert N. , Johansson Mattias , Key Timothy J. , Khaw Kay-Tee , Kolonel Laurence N. , Lagiou Pagona , Lee I-Min , LeMarchand Loic , Lund Eiliv , Ma Jing , Onland-Moret N. Charlotte , Overvad Kim , Rodriguez Laudina , Sacerdote Carlotta , Sánchez Maria-José , Stampfer Meir J. , Stattin Pär , Stram Daniel O. , Thomas Gilles , Thun Michael J. , Tjønneland Anne , Trichopoulos Dimitrios , Tumino Rosario , Virtamo Jarmo , Weinstein Stephanie J. , Willett Walter C. , Yeager Meredith , Zhang Shumin M. , Kaaks Rudolf , Riboli Elio , Ziegler Regina G. , Kraft Peter 
Published: November 2010

AbstractBackground: Circulating levels of insulin-like growth factor I (IGF-I) and its main binding protein, IGF binding protein 3 (IGFBP-3), have been associated with risk of several types of cancer. Heritable factors explain up to 60% of the variation in IGF-I and IGFBP-3 in studies of adult twins.Methods: We systematically examined common genetic variation in 18 genes in the IGF signaling pathway for associations with circulating levels of IGF-I and IGFBP-3. A total of 302 single nucleotide polymorphisms (SNP) were genotyped in &gt;5,500 Caucasian men and 5,500 Caucasian women from the Breast and Prostate Cancer Cohort Consortium.Results: After adjusting for multiple testing, SNPs in the IGF1 and SSTR5 genes were significantly associated with circulating IGF-I (P &lt; 2.1 × 10−4); SNPs in the IGFBP3 and IGFALS genes were significantly associated with circulating IGFBP-3. Multi-SNP models explained R2 = 0.62% of the variation in circulating IGF-I and 3.9% of the variation in circulating IGFBP-3. We saw no significant association between these multi-SNP predictors of circulating IGF-I or IGFBP-3 and risk of prostate or breast cancers.Conclusion: Common genetic variation in the IGF1 and SSTR5 genes seems to influence circulating IGF-I levels, and variation in IGFBP3 and IGFALS seems to influence circulating IGFBP-3. However, these variants explain only a small percentage of the variation in circulating IGF-I and IGFBP-3 in Caucasian men and women.Impact: Further studies are needed to explore contributions from other genetic factors such as rare variants in these genes and variation outside of these genes. Cancer Epidemiol Biomarkers Prev; 19(11); 2877–87. ©2010 AACR.
Associations of Folate, Vitamin B12, Homocysteine, and Folate-Pathway Polymorphisms with Prostate-Specific Antigen Velocity in Men with Localized Prostate Cancer
Authors: Collin Simon M. , Metcalfe Chris , Refsum Helga , Lewis Sarah J. , Davey Smith George , Cox Angela , Davis Michael , Marsden Gemma , Johnston Carole , Lane J. Athene , Donovan Jenny L. , Neal David E. , Hamdy Freddie C. , Smith A. David , Martin Richard M. 
Published: November 2010

Abstract
Background: Vitamin B12, holo-haptocorrin, and the folate-pathway single-nucleotide polymorphisms MTR 2756A&gt;G and SHMT1 1420C&gt;T have been associated with an increased risk of prostate cancer. We investigated whether these and other elements of folate metabolism were associated with prostate-specific antigen (PSA) velocity (PSAV) as a proxy measure of prostate cancer progression in men with localized prostate cancer.
Methods: We measured plasma folate, B12, holo-haptocorrin, holo-transcobalamin, total transcobalamin, and total homocysteine at diagnosis in 424 men (ages 45-70 years) with localized prostate cancer in a U.K.-wide population-based cohort. Thirteen folate-pathway single-nucleotide polymorphisms were genotyped for 311 of these men. Postdiagnosis PSAV (continuous measure and with a threshold set a priori at 2 ng/mL/y) was estimated from repeat PSA measurements.
Results: Median follow-up time was 2.5 (range, 0.8-5.6) years. Vitamin B12, holo-haptocorrin, holo-transcobalamin, total transcobalamin, and total homocysteine were not associated with postdiagnosis PSAV. Folate was associated with an increased risk of PSAV &gt;2 ng/mL/y [odds ratio (OR) per unit increase in loge concentration, 1.57; 95% confidence interval (95% CI), 0.98-2.51; P = 0.06]. MTRR 66A&gt;G (rs1801394) was associated with a reduced risk (recessive model OR, 0.33; 95% CI, 0.11-0.97; P = 0.04), and SHMT1 1420C&gt;T (rs1979277) with an increased risk (per-allele OR, 1.49; 95% CI, 0.93-2.37; P = 0.09) of PSAV &gt;2 ng/mL/y.
Conclusions: We found weak evidence that higher folate levels may be associated with faster progression of localized prostate cancer.
Impact: Long-term follow-up is needed to test associations with metastases and mortality, and the observed genetic effects require replication. Cancer Epidemiol Biomarkers Prev; 19(11); 2833–8. ©2010 AACR.
A Multilayer Upper-Boundary Condition for Longwave Radiative Flux to Correct Temperature Biases in a Mesoscale Model
Authors: Cavallo Steven M. , Dudhia Jimy , Snyder Chris 
Published: November 2010

Abstract
An upper-level cold bias in potential temperature tendencies of 10 K day−1, strongest at the top of the model, is observed in Weather Research and Forecasting (WRF) model forecasts. The bias originates from the Rapid Radiative Transfer Model longwave radiation physics scheme and can be reduced substantially by 1) modifying the treatment within the scheme by adding a multilayer buffer between the model top and top of the atmosphere and 2) constraining stratospheric water vapor to remain within the estimated climatology in the stratosphere. These changes reduce the longwave heating rate bias at the model top to ±0.5 K day−1. Corresponding bias reductions are also seen, particularly near the tropopause.
Mode of occurrence of traumatic head injuries in male patients with cluster headache or migraine: Is there a connection with lifestyle?
Authors: Lambru Giorgio , Castellini Paola , Manzoni Gian Camillo , Torelli Paola 
Published: November 2010

Introduction: Our study objective was to investigate the mode of occurrence of traumatic head injury in episodic cluster headache and migraine patients. Methods: We conducted a retrospective study on 400 male patients, 200 with cluster headache (cases) and 200 with migraine (controls). We investigated the frequency and mode of occurrence of traumatic head injury and some lifestyle habits. Results: The number of traumatic head injuries was significantly higher in cases than in controls (adjusted odds ratio [OR] = 2.0; 95% confidence interval [CI] = 1.5–2.8). Cases were more often responsible for the head traumas (adjusted OR = 2.6; 95% CI = 1.3–4.9) and reported a significantly higher proportion of injuries during scuffles or brawls (OR = 6.5; 95% CI = 2.9–14.8). Compared with other cluster headache patients, cases responsible for traumatic head injuries were more frequently heavy alcohol ( p = .000), heavy tobacco ( p = .03) and heavy coffee consumers ( p = .003). Conclusions: Cluster headache patients (a) had traumatic head injuries more frequently than migraineurs; and (b) were more often responsible for them, perhaps due to particular behaviours related to their lifestyles.
A novel adenovirus of Western lowland gorillas (Gorilla gorilla gorilla)
Authors: Wevers Diana , Leendertz Fabian H , Scuda Nelly , Boesch Christophe , Robbins Martha M , Head Josephine , Ludwig Carsten , Kühn Joachim , Ehlers Bernhard 
Published: November 2010

Abstract
Adenoviruses (AdV) broadly infect vertebrate hosts including a variety of primates. We identified a novel AdV in the feces of captive gorillas by isolation in cell culture, electron microscopy and PCR. From the supernatants of infected cultures we amplified DNA polymerase (DPOL), preterminal protein (pTP) and hexon gene sequences with generic pan primate AdV PCR assays. The sequences in-between were amplified by long-distance PCRs of 2 - 10 kb length, resulting in a final sequence of 15.6 kb. Phylogenetic analysis placed the novel gorilla AdV into a cluster of primate AdVs belonging to the species Human adenovirus B (HAdV-B). Depending on the analyzed gene, its position within the cluster was variable. To further elucidate its origin, feces samples of wild gorillas were analyzed. AdV hexon sequences were detected which are indicative for three distinct and novel gorilla HAdV-B viruses, among them a virus nearly identical to the novel AdV isolated from captive gorillas. This shows that the discovered virus is a member of a group of HAdV-B viruses that naturally infect gorillas. The mixed phylogenetic clusters of gorilla, chimpanzee, bonobo and human AdVs within the HAdV-B species indicate that host switches may have been a component of the evolution of human and non-human primate HAdV-B viruses.
Pulmonary exposure to carbon black nanoparticles and vascular effects
Authors: Vesterdal Lise K , Folkmann Janne K , Jacobsen Nicklas R , Sheykhzade Majid , Wallin Håkan , Loft Steffen , Møller Peter 
Published: November 2010

Abstract

Background
Exposure to small size particulates is regarded as a risk factor for cardiovascular diseases.

Methods
We exposed young and aged apolipoprotein E knockout mice (apoE

-/-
) to carbon black (Printex 90, 14 nm) by intratracheal instillation, with different dosing and timing, and measured vasomotor function, progression of atherosclerotic plaques, and VCAM-1, ICAM-1, and 3-nitrotyrosine in blood vessels. The mRNA expression of VCAM-1, ICAM-1, HO-1, and MCP-1 was examined in lung tissue.

Results
Young apoE

-/-
mice exposed to two consecutive 0.5 mg/kg doses of carbon black exhibited lower acetylcholine-induced vasorelaxation in aorta segments mounted in myographs, whereas single doses of 0.05-2.7 mg/kg produced no such effects. The phenylephrine-dependent vasocontraction response was shifted toward a lower responsiveness in the mice exposed once to a low dose for 24 hours. No effects were seen on the progression of atherosclerotic plaques in the aged apoE

-/-
mice or on the expression of VCAM-1 and ICAM-1 and the presence of 3-nitrotyrosine in the vascular tissue of either young or aged apoE

-/-
mice. The expression of MCP-1 mRNA was increased in the lungs of young apoE

-/-
mice exposed to 0.9-2.7 mg/kg carbon black for 24 hours and of aged apoE

-/-
mice exposed to two consecutive 0.5 mg/kg doses of carbon black seven and five weeks prior to sacrifice.

Conclusion
Exposure to nano-sized carbon black particles is associated with modest vasomotor impairment, which is associated neither with nitrosative stress nor with any obvious increases in the expression of cell adhesion proteins on endothelial cells or in plaque progression. Evidence of pulmonary inflammation was observed, but only in animals exposed to higher doses.
Phenotypic Study of Human Gingival Fibroblasts in a Medium Enriched With Platelet Lysate
Authors: Naveau Adrien , Lataillade Jean‐Jacques , Fournier Benjamin Philippe , Couty Ludovic , Prat Marie , Ferre François Côme , Gourven Muriel , Durand Eric , Coulomb Bernard , Lafont Antoine , Gogly Bruno 
Published: November 2010

Background: The modulation abilities of gingival fibroblasts open new therapeutic strategies for the treatment of vascular diseases (e.g., aneurism) and irradiation burns. Culture media are classically supplemented with animal sera to provide nutriments. Unfortunately, because of their potential for interspecies transmission of microorganisms, these media are not used for cells destined for human transplantation. This preliminary phenotypic study aims to test a serum‐free (SF) culture medium for human gingival fibroblasts (hGF) supplemented with human platelet lysates (PLs) for rapid cell expansion.Methods: An SF medium was first elaborated to compete with hGF proliferation in a reference medium containing 10% fetal bovine serum (BSmedium). Adhesion, proliferation, and doubling kinetics were run in the presence of PLs (SF+PL). Cytoskeletal proteins were analyzed and chromosomal abnormalities were evaluated by karyotype analyses. The SF+PL influence on secretion of molecules implied in tissue remodeling (i.e., matrix metalloproteinases [MMPs], their tissue inhibitors [TIMPs], and several growth factors) was studied.Results: SF+PL increased the proliferation rate 1.5‐fold in a week compared to BSmedium. Cytoskeleton protein expression was similar in BSmedium and in SF+PL. Chromosomal abnormalities were rare in SF+PL. MMP‐1, MMP‐2, MMP‐3, MMP‐7, MMP‐9, TIMP‐1, and the growth factors interleukin‐1β and ‐4 and transforming growth factor‐β1 secretions were stable during the experiment. TIMP‐2 and interleukin‐6 were slightly decreased in SF+PL compared to BSmedium.Conclusion: While waiting confirmation from a proteomic approach, this SF culture medium could allow a secured faster hGF proliferation adapted for human cell transplant therapy.
Inflammation and Genetic Risk Indicators for Early Periodontitis in Adults
Authors: Stashenko Philip , Van Dyke Thomas , Tully Patrice , Kent Ralph , Sonis Stephen , Tanner Anne C.R. 
Published: November 2010

Background: This report is a further analysis of a study designed to determine clinical and microbial risk indicators for progressing periodontitis.Methods: One hundred ninety subjects who were periodontally healthy or had early signs of periodontitis (age range: 20 to 40 years) were monitored clinically at 6‐month intervals followed by supragingival cleaning. At each visit, gingival crevicular fluid (GCF) and blood were collected for determination of interleukin (IL)‐1β content (in GCF) and IL‐1 genotype (in blood). Interproximal sites with a >1.5‐mm increase in clinical attachment over 18 months were considered disease active. Characteristics were compared between active and inactive subjects.Results: IL‐1β levels in GCF increased with the severity of disease and correlated well with clinical signs of incipient disease. However, the IL‐1 genotype did not show any significant associations with disease or the extent of disease.Conclusion: Indicators of inflammation may be important clinical determinants of future periodontal disease progression, but the IL‐1 genotype was not a risk indictor for early (slight) periodontitis as defined in this subject population.
Fuzzy-based Vascular Structure Enhancement in Time-of-Flight MRA Images for Improved Segmentation
Authors: Schmidt-Richberg A. , Fiehler J. , Illies T. , Möller D. , Handels H. , Säring D. , Forkert N. D. 
Published: November 2010

Summary
Objectives: Cerebral vascular malformations might lead to strokes due to occurrence of ruptures. The rupture risk is highly related to the individual vascular anatomy. The 3D Time-of-Flight (TOF) MRA technique is a commonly used non-invasive imaging technique for exploration of the vascular anatomy. Several clinical applications require exact cerebrovascular segmentations from this image sequence. For this purpose, intensity-based segmentation approaches are widely used. Since small low-contrast vessels are often not detected, vesselness filter-based segmentation schemes have been proposed, which contrari-wise have problems detecting malformed vessels. In this paper, a fuzzy logic-based method for fusion of intensity and vesselness information is presented, allowing an improved segmentation of malformed and small vessels at preservation of advantages of both approaches.
Methods: After preprocessing of a TOF dataset, the corresponding vesselness image is computed. The role of the fuzzy logic is to voxel-wisely fuse the intensity information from the TOF dataset with the corresponding vesselness information based on an analytically designed rule base. The resulting fuzzy parame ter image can then be used for improved cerebrovascular segmentation.
Results: Six datasets, manually segmented by medical experts, were used for evaluation. Based on TOF, vesselness and fused fuzzy parameter images, the vessels of each patient were segmented using optimal thresholds computed by maximizing the agreement to manual segmentations using the Tanimoto coefficient. The results showed an overall improvement of 0.054 (fuzzy vs. TOF) and 0.079 (fuzzy vs. vesselness). Furthermore, the evaluation has shown that the method proposed yields better results than statistical Bayes classification.
Conclusion: The proposed method can automatically fuse the benefits of intensity and vesselness information and can improve the results of following cerebrovascular segmentations.
Gene characterization of two digestive serine proteases in Sitodiplosis mosellana: implications for alternative control strategies
Authors: Arrueta Lourdes D. , Shukle Richard H. , Wise Ian L. , Mittapalli Omprakash 
Published: November 2010

AbstractTwo full-length cDNA sequences encoding digestive serine proteases (designated as SmPROT-1 and SmPROT-2) were recovered from the midgut of the orange wheat blossom midge, Sitodiplosis mosellana (Géhin) (Diptera: Cecidomyiidae), in an ongoing expressed sequence tag project. The deduced amino acid sequences shared homology with digestive serine proteases from insect and non-insect species, including conserved regions such as the catalytic triad, active pocket, and conserved structural motifs. Secretory signal peptides in both proteases at the N-terminals indicate that these proteins could function as midgut digestive serine proteases. A phylogenetic analysis grouped SmPROT-1 and SmPROT-2 with trypsin-like and chymotrysin-like serine proteases, respectively. Quantitative real-time PCR analysis showed that SmPROT-1 and SmPROT-2 were expressed predominantly in the midgut rather than in other tissues (fat body and salivary glands). Expression analyses revealed high mRNA levels for the feeding instars (1st- and 2nd-instar larvae) compared with other stages (neonate, 3rd instar, pupa, and adult). These results provide new insights into the biology of S. mosellana and are discussed in the context of developing alternative control strategies.
Support for religio‐political aggression among teenaged boys in Gaza: Part II: Neuroendocrinological findings
Authors: Victoroff Jeff , Quota Samir , Adelman Janice R. , Celinska Barbara , Stern Naftali , Wilcox Rand , Sapolsky Robert M. 
Published: November 2010

AbstractHormones seem to play important roles in the regulation of human aggression. Multiple studies have confirmed that testosterone (T) levels exhibit complex relationships with aggression, dominance, and/or risk‐taking behavior. Some evidence suggests that cortisol (CORT) interacts with T and may also be associated with aspects of mood and aggression. However, almost no research to date has investigated the possibility that these neuroendocrine factors are associated with variations in political attitudes or with political aggression. During the second intifada, we tested the hypothesis that morning salivary T and/or salivary CORT levels might be associated with self‐rated aggression or with support for religio‐political aggression (RPA) among 14‐year‐old Palestinian boys living in Gaza. We obtained and averaged weekly 09:00 hr salivary measures of T and CORT for more than 1 month. Averaged morning T levels did not correlate with self‐rated aggression, but were positively associated with agreement with the statement “religious ends justify any means,” (r = .355, P = .014) and marginally associated with a composite measure of support for RPA (r = .247, P = .094). Average CORT levels were inversely correlated with self‐rated aggression (r = −.328, P = .037) and with anger (r = −.373, P = .016), but CORT levels were not associated with support for RPA or with the statement “religious ends justify any means.” Acknowledging that a modest sample size and methodological issues necessarily limit confidence in our conclusions, these results may represent the first findings regarding neurobiological correlates of support for political aggression. Aggr. Behav. 37:121–132, 2011. © 2010 Wiley‐Liss, Inc.
Impact modification of poly(trimethylene terephthalate)/polypropylene blend nanocomposites: Fabrication and characterization
Authors: Upadhyay Dinesh , Mohanty Smita , Nayak Sanjay K. , Parvaiz M. Rahail , Panda Bishnu P. 
Published: November 2010

AbstractA poly(trimethylene terephthalate) (PTT)/polypropylene (PP) blend and the nanocomposites were prepared with and without the addition of a compatibilizer precursor [maleic anhydride grafted polypropylene (MAPP)]. A reactive route was used for the compatibilization with the addition of MAPP during melt blending in a batch mixer. Organically modified nanoclays were used as nanoscale reinforcements to prepare the blend nanocomposites. Mechanical tests revealed optimum performance characteristics at a PTT/PP blend ratio of 80 : 20. Furthermore, incorporation of nanoclays up to 3 wt % showed a higher impact strength and higher tensile strength and modulus in the blend nanocomposites compared to the optimized blend. The nanocomposite formation was established through X‐ray diffraction and transmission electron microscopy (TEM). Thermal measurements were carried out with differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). DSC thermograms revealed an increase in the crystallization temperature in the presence of the nanoclays in the blend system containing Cloisite 30B. TGA thermograms also indicated that the thermal stability of blend increased with the incorporation of Cloisite 30B. Furthermore, dynamic mechanical analysis measurements showed that the Cloisite 30B nanocomposite had the maximum modulus compared to other nanocomposites. TEM micrographs confirmed an intercalated morphology in the blend nanocomposites. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Surface preparation for adhesive bonding of polycyanurate‐based fiber‐reinforced composites using atmospheric plasma treatment
Authors: Zaldivar R. J. , Kim H. I. , Steckel G. L. , Patel D. , Morgan B. A. , Nokes J. P. 
Published: November 2010

AbstractIn this article, the effects of atmospheric plasma treatment on the microstructural, chemical, and mechanical behavior of epoxy‐bonded polycyanurate composites are investigated. Adhesive bond strength of plasma‐treated specimens exhibited strength increases of over 35% to that of peel‐ply and solvent‐wiped surface preparation techniques. The improvements were as much as 50% greater than those obtained using abrasive surface preparation techniques. X‐ray photoelectron spectroscopy analysis showed an increase in the surface concentration of oxygen as a function of plasma treatment passes. However, the levels were substantially lower than that of epoxy composites treated under identical conditions. In addition, the concentration of carboxyl groups (OCO), which have been associated with improved adhesive strength in epoxy‐based composites, was shown to saturate in cyanate ester composites after a much lower exposure period than what was observed when treating epoxies. The effect of plasma surface treatment on the surface morphology of the cyanate ester composite was also studied using scanning electron microscopy and atomic force microscopy. Atomic force microscopy analysis showed a progressive increase in surface roughness with treatment; however, this increase only translated into a marginal increase in surface area and is not believed to contribute significantly to adhesive strength. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011