bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarities and Differences of Self-Care Behaviors Between Korean Americans and Caucasian Americans With Heart Failure
Authors: Jang Yeonsoo , Toth Jean , Yoo Hyera 
Published: April 2012

Purpose: To compare the differences of self-care behaviors between Korean Americans with heart failure (HF) and Caucasian Americans with HF. Method: Ninety ( N = 90) participants (45 Korean Americans and 45 Caucasian Americans) were recruited for this study. A two-group, comparative, descriptive design using the Revised Heart Failure Self-Care Behavior Scale was used to assess self-care behaviors. Results: Self-care behavior was not significantly different between the two groups ( p > .05). However, culture-specific self-care behaviors were evident between two racial groups. Discussion: Implementation of culturally congruent education programs could be useful in preventing and managing HF. Further studies comparing self-care behaviors should be conducted in diverse racial populations.
Acculturation and Health Status Among Hispanic American Elders
Authors: Buscemi Charles P. , Williams Christine , Tappen Ruth M. , Blais Kathleen 
Published: April 2012

Purpose: Hispanic Americans are at risk for health-related problems. Disparities in diseases such as diabetes and obesity, poor access to health services, and lack of health insurance have placed Hispanic Americans at a disadvantage. Sociocultural factors such as acculturation and its relationship to health require further investigation. The primary purpose of this study was to identify the relationship between acculturation and health in Hispanic American elders and examine the interrelationships of acculturation, health status, age, gender, education, years in the United States, and income. Design: This descriptive correlational study was a secondary analysis of data from a large study titled Culture Bias in Testing Expressive Ability in Dementia. Methods: A total sample of 132 community-dwelling Hispanic American elders was used. The Cross Cultural Measure of Acculturation was used to measure acculturation, and health status was measured using the SF-8® Health Survey. Correlation and multiple linear regressions were used to analyze the data. Discussion/Conclusions: Findings from the study revealed that participants who were more acculturated to mainstream American culture reported their mental health to be better but not their physical health. This is an important contribution to advancing knowledge about cultural and health issues among Hispanic American elders, with implications for the clinical setting and for providing more culturally competent care.
Attitudes Toward and Justification for Wife Abuse Among Syrian Medical and Nursing Students
Authors: Gharaibeh Muntaha K. , Abu-Baker Nesrin N. , Aji Sanaa 
Published: April 2012

Purpose: To explore the perceptions of and attitudes toward violence and beliefs of contextual justification of wife abuse among Syrian medical and nursing students. Design and Method: A descriptive, cross-sectional design was used. The Perceptions of and Attitudes toward Wife Abuse Questionnaire was used to collect data from a convenience sample of 621 medical and nursing students from three public universities in Syria. Results: Only 18.4% of the students had positive attitudes toward interpersonal violence reflecting low tolerance to wife beating and use of physical force for problem solving and child discipline, and 16.1% did not justify wife beating. Medical, older, female students, from urban areas, with more educated parents, and those who did not experience violence or witness violence between their parents had significantly more positive attitudes toward wife abuse and significantly less justification of wife beating ( p < .05). Conclusion and Implications: Education about violence against women of future medical and nursing students is the responsibility of medical and nursing educators and health policy makers, who have to acknowledge the influence of the sociocultural factors in shaping student’s attitudes toward wife abuse and develop strategies to enhance these attitudes at the early stages of professional preparation.
Experiencias de promoción de la salud y gobernanza en el ámbito local de México: retos y limitaciones
Authors: Arenas-Monreal Luz , Jasso-Victoria Rogelio , Bonilla-Fernández Pastor , Villanueva-Borbolla y Maria Angeles 
Published: April 2012

Resumen Dentro de la promoción de la salud, hablar de gobernanza y de los distintos actores sociales con quienes se establecen alianzas para mejorar la salud de la población, requiere un análisis de las características específicas del desarrollo socioeconómico y político en el que se encuentre la región o el país y fortalecer la participación ciudadana con la finalidad de generar mayores espacios de interacción entre los actores sociales comunitarios y conectar de manera más eficiente al Estado con las necesidades poblacionales propiciando una mejor toma de decisiones y desarrollando un mejor estilo de gobierno. En un país como México con altos índices de pobreza, desempleo, una creciente desigualdad y baja escolaridad ¿de qué manera impulsar la gobernanza?; ¿es posible impulsar procesos de gobernanza en situaciones de pobreza?; ¿es suficiente considerar las alianzas y las redes para fortalecer las salud y el desarrollo? El objetivo de este manuscrito es reflexionar sobre los retos y limitaciones que ofrece el contexto mexicano para impulsar la gobernanza, a partir de experiencias comunitarias en el espacio local y dentro del marco de la promoción de la salud. Desde nuestra experiencia, la gobernanza se ve limitada por el aumento de la pobreza en nuestro país y por la existencia de un sistema autoritario y con poder centralizado. Sin embargo, a través de la metodología de investigación-acción-participativa y educación popular, la propia población de estudio ha incrementado las acciones de abogacía y gestión de recursos para su propio desarrollo. Se reconoce la necesidad de abrir espacios de reflexión y discusión acerca de los alcances, logros, retos y limitaciones de la promoción de la salud y la gobernanza en los distintos contextos dentro de los países en vías de desarrollo.
La racialisation de la santé publique aux États-Unis : entre pouvoir sur la vie et droit de laisser mourir
Authors: Cloos Patrick 
Published: April 2012

Résumé Aux États-Unis, une intensification de l’usage de la race en santé publique a récemment été notée ; une idée qui est pourtant controversée dans les sciences. La race a été vue dans ce contexte comme un objet de discours entre pouvoirs et savoirs, un objet qui se réfère au corps devenu au cours des derniers siècles un site discursif pour représenter la différence. Cet article s’appuie sur une analyse de documents de la santé publique parus aux États-Unis et issus de bureaux fédéraux et d’une importante revue spécialisée dans le domaine sanitaire, qui ont été publiés entre 2001 et 2009. Cette étude a analysé la manière dont la race est représentée, produite comme objet de connaissance et régulée par les pratiques discursives dans ces documents. Les résultats décrivent deux processus enchevêtrés, la racialisation et la sanitarisation, qui concourent à reformuler l’idée de race. Le premier est un ensemble d’opérations qui visent à identifier, à situer et à opposer les sujets et les groupes à partir de labels standardisés. La sanitarisation assure la traduction des groupes racialisés en termes de maladies, de comportements, de vie ou de mort. Ces pratiques aboutissent à la caractérisation et à la formation d’objets racialisés et sanitarisés et à des stéréotypes ; un ensemble d’opérations qui a tendance à naturaliser la différence. La racialisation apparaît également tiraillée entre un pouvoir sur la vie et un droit de laisser mourir. Enfin, cette étude propose aux acteurs de la santé publique de sortir des frontières imposées par le discours racialisant.
Carbonatites and associated nephelinites from São Vicente, Cape Verde Islands
Authors: de Ignacio C. , Muñoz M. , Sagredo J. 
Published: April 2012

AbstractThe island of São Vicente has the most abundant carbonatite outcrops in the Cape Verde Islands. A field survey of the main outcrops has shown that they consist of extrusive carbonatites, carbonatite dykes and small apophyses of intrusive carbonatite. These outcrops are spatially related to nephelinites. The compositions of the extrusive carbonatites and dykes plot close to, and within, the magnesiocarbonatite field. In contrast, the intrusive carbonatites are calciocarbonatites, with similar average strontium contents to those of extrusive carbonatites and dykes (around 4000 ppm), but remarkably low barium, niobium and total rare earth element concentrations. Whole-rock geochemistry indicates a strong affinity between the nephelinites and intrusive carbonatites, such that the latter could represent fractionation products of the same parental magma. This is in agreement with radiogenic isotope geochemistry, which shows a very restricted range of compositions in the Sr, Nd and Pb systems. Fractionation from a common parental magma occurred in two main steps: high-temperature nephelinite crystallization and high-temperature carbonatite immiscibility. The carbonatitic melts crystallized in two different environments, as follows: (1) a shallow intrusive environment, giving rise to the early calciocarbonatite cumulates; and (2) a vapour-dominated, extrusive environment, producing the later magnesiocarbonatites.
Tracing the chemical evolution of primary pyrochlore from plutonic to volcanic carbonatites: the role of fluorine
Authors: Bambi A. C. J. M. , Costanzo A. , Gonçalves A. O. , Melgarejo J. C. 
Published: April 2012

AbstractThree Angolan carbonatites were selected to evaluate the change in composition of pyrochlores during magmatic evolution: the Tchivira carbonatites occur in a plutonic complex, the Bonga carbonatites represent hypabyssal carbonatites and the Catanda carbonatites are volcanic in origin. In Tchivira pyrochlore, zoning is poorly developed; fluorine is dominant at the Y site; chemical zoning may arise as a result of substitutions for Nb in the B site; and the rare earth element (REE), U, Th and large-ion lithophile element (LILE) contents are very low. Pyrochlores from Bonga show oscillatory zonation; the F and Na contents are lower than those in the pyrochlores from Tchivira; and as substitution of Na at the A site increases, the Th, U, REE contents and inferred vacancies also increase. Pyrochlores from Catanda display complex textures. They generally have a rounded corroded core, which is mantled by two or three later generations. The core composition is similar to the Bonga pyrochlores. The rims are enriched in Zr, Ta, Th, Ce and U, but depleted in F and Na. In pyrochlores from the Angolan carbonatites, the F and Na contents decrease from plutonic to volcanic settings and there is enrichment of Th, U and REE in the A site and Ta and Zr in the B site. Zoning may be explained by changes in the activity of F, due to the crystallization of fluorite or apatite in the plutonic and hypabyssal carbonatites, or to volatile exsolution in the volcanic carbonatites.
Niobium and rare earth minerals from the Virulundo carbonatite, Namibe, Angola
Authors: Torró L. , Villanova C. , Castillo M. , Campeny M. , Gonçalves A. O. , Melgarejo J. C. 
Published: April 2012

AbstractThe Virulundo carbonatite in Angola is one of the largest in the world and contains pyrochlore as an accessory mineral in all of the carbonatite units (calciocarbonatites, ferrocarbonatites, carbonatite breccias and trachytoids). The primary magmatic pyrochlore is fluorine dominant and typically contains about equal molar quantities of Ca and Na at the A site. High-temperature hydrothermal processes have resulted in the pseudomorphic replacement of the primary pyrochlore by a second generation of pyrochlore with less F and Na. Low-temperature hydrothermal replacement of the first and second generation pyrochlore, associated with quartz-carbonate-fluorite vein formation in the carbonatite, has produced a third generation of pyrochlore, with a high Sr content. The Sr appears to have been released by low-temperature hydrothermal replacement of the primary magmatic carbonates. Finally, supergene alteration processes have produced late-stage carbonates, goethite, hollandite and rare earth element (REE) minerals (mainly synchysite-(Ce), britholite-(Ce), britholite-(La), cerite-(Ce)). Cerium separated from the other REE s in oxidizing conditions and Ce4+ was incorporated into a late generation of supergene pyrochlore, which is strongly enriched in Ba and strongly depleted in Ca and Na.
Silicate–carbonate liquid immiscibility and crystallization of carbonate and K-rich basaltic magma: insights from melt and fluid inclusions
Authors: Solovova I. P. , Girnis A. V. 
Published: April 2012

AbstractThis paper reports an investigation of the crystallization products of K-rich silicate and carbonate melts trapped as melt inclusions in clinopyroxene phenocrysts from the Dunkeldyk alkaline igneous complex in the Tajik Republic. Heating experiments on the melt inclusions suggest that the carbonate melt was formed by liquid immiscibility at 1180°C and ∼0.5 GPa. The carbonate-rich inclusions are dominated by Sr-bearing calcite, and rich in incompatible elements. Most of the silicate minerals are SiO2-poor and rich in K, Ba and Ti. Leucite, kalsilite and aegirine are the earliest magmatic minerals. High Ba and Ti contents in the melt resulted in the crystallization of Ba-rich K-feldspar, titanite, perovskite and Ti-bearing garnet, and the rare Ba-Ti silicates fresnoite and delindeite. The last minerals to crystallize from volatile-rich melts and fluids were aegirine, götzenite, K-Ba- and Ca-Sr-bearing zeolites, fluorite and strontium-rich baryte. Interaction of the early minerals with residual melts and fluids produced Ba-rich phlogopite and Sr-rich apatite.
C/EBPα and DEK coordinately regulate myeloid differentiation
Authors: Koleva Rositsa I. , Ficarro Scott B. , Radomska Hanna S. , Carrasco-Alfonso Marlene J. , Alberta John A. , Webber James T. , Luckey C. John , Marcucci Guido , Tenen Daniel G. , Marto Jarrod A. 
Published: April 2012

Abstract
The transcription factor C/EBPα is a critical mediator of myeloid differentiation and is often functionally impaired in acute myeloid leukemia. Recent studies have suggested that oncogenic FLT3 activity disrupts wild-type C/EBPα function via phosphorylation on serine 21 (S21). Despite the apparent role of pS21 as a negative regulator of C/EBPα transcription activity, the mechanism by which phosphorylation tips the balance between transcriptionally competent and inhibited forms remains unresolved. In the present study, we used immuno-affinity purification combined with quantitative mass spectrometry to delineate the proteins associated with C/EBPα on chromatin. We identified DEK, a protein with genetic links to leukemia, as a member of the C/EBPα complexes, and demonstrate that this association is disrupted by S21 phosphorylation. We confirmed that DEK is recruited specifically to chromatin with C/EBPα to enhance GCSFR3 promoter activation. In addition, we demonstrated that genetic depletion of DEK reduces the ability of C/EBPα to drive the expression of granulocytic target genes in vitro and disrupts G-CSF–mediated granulocytic differentiation of fresh human BM-derived CD34+ cells. Our data suggest that C/EBPα and DEK coordinately activate myeloid gene expression and that S21 phosphorylation on wild-type C/EBPα mediates protein interactions that regulate the differentiation capacity of hematopoietic progenitors.
Prevalence of collagen VII-specific autoantibodies in patients with autoimmune and inflammatory diseases
Authors: Licarete Emilia , Ganz Susanne , Recknagel Martin J , Di Zenzo Giovanni , Hashimoto Takashi , Hertl Michael , Zambruno Giovanna , Hundorfean Gheorghe , Mudter Jonas , Neurath Markus F , Bruckner-Tuderman Leena , Sitaru Cassian 
Published: April 2012

Abstract

Background
Autoimmunity to collagen VII is typically associated with the skin blistering disease epidermolysis bullosa acquisita (EBA), but also occurs occasionally in patients with systemic lupus erythematosus or inflammatory bowel disease. The aim of our present study was to develop an accurate immunoassay for assessing the presence of autoantibodies against collagen VII in large cohorts of patients and healthy donors.

Methods
Based on in silico antigenic analysis and previous wetlab epitope mapping data, we designed a chimeric collagen VII construct containing all collagen VII epitopes with higher antigenicity. ELISA was performed with sera from patients with EBA (n = 50), Crohn's disease (CD, n = 50), ulcerative colitis (UC, n = 50), bullous pemphigoid (BP, n = 76), and pemphigus vulgaris (PV, n = 42) and healthy donors (n = 245).

Results
By ELISA, the receiver operating characteristics analysis yielded an area under the curve of 0.98 (95% CI: 0.9638-1.005), allowing to set the cut-off at 0.32 OD at a calculated specificity of 98% and a sensitivity of 94%. Running the optimized test showed that serum IgG autoantibodies from 47 EBA (94%; 95% CI: 87.41%-100%), 2 CD (4%; 95% CI: 0%-9.43%), 8 UC (16%; 95% CI: 5.8%-26%), 2 BP (2.63%; 95% CI: 0%-6.23%), and 4 PV (9.52%; 95% CI: 0%-18.4%) patients as well as from 4 (1.63%; 95% CI: 0%-3.21%) healthy donors reacted with the chimeric protein. Further analysis revealed that in 34%, 37%, 16% and 100% of sera autoantibodies of IgG1, IgG2, IgG3, and IgG4 isotype, respectively, recognized the recombinant autoantigen.

Conclusions
Using a chimeric protein, we developed a new sensitive and specific ELISA to detect collagen specific antibodies. Our results show a low prevalence of collagen VII-specific autoantibodies in inflammatory bowel disease, pemphigus and bullous pemphigoid. Furthermore, we show that the autoimmune response against collagen VII is dominated by IgG4 autoantibodies. The new immunoassay should prove a useful tool for clinical and translational research and should improve the routine diagnosis and disease monitoring in diseases associated with collagen VII-specific autoimmunity.
Rationale and design of the RESOLVE trial: lanreotide as a volume reducing treatment for polycystic livers in patients with autosomal dominant polycystic kidney disease
Authors: Gevers Tom JG , Chrispijn Melissa , Wetzels Jack FM , Drenth Joost PH 
Published: April 2012

Abstract

Background
A large proportion of patients with autosomal dominant polycystic kidney disease (ADPKD) suffers from polycystic liver disease. Symptoms arise when liver volume increases. The somatostatin analogue lanreotide has proven to reduce liver volume in patients with polycystic liver disease. However, this study also included patients with isolated polycystic liver disease (PCLD). The RESOLVE trial aims to assess the efficacy of lanreotide treatment in ADPKD patients with symptomatic polycystic livers. In this study we present the design of the RESOLVE trial.

Methods/design
This open-label clinical trial evaluates the effect of 6 months of lanreotide in ADPKD patients with symptomatic polycystic livers. Primary outcome is change in liver volume determined by computerised tomography-volumetry. Secondary outcomes are changes in total kidney volume, kidney intermediate volume and renal function. Furthermore, urinary (NGAL, α1-microglobulin, KIM-1, H-FABP, MCP-1) and serum (fibroblast growth factor 23) biomarkers associated with ADPKD disease severity are assessed to investigate whether these biomarkers predict treatment responses to lanreotide. Moreover, safety and tolerability of the drug in ADPKD patients will be assessed.

Discussion
We anticipate that lanreotide is an effective therapeutic option for ADPKD patients with symptomatic polycystic livers and that this trial aids in the identification of patient related factors that predict treatment response.

Trial registration number
Clinical trials.gov NCT01354405
Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients
Authors: Ihnen Maike , Kress Kerstin , Kersten Jan Felix , Kilic Ergin , Choschzick Matthias , Zander Hilke , Müller Volkmar , Mahner Sven , Jänicke Fritz , Woelber Linn , Milde-Langosch Karin 
Published: April 2012

Abstract

Background
An altered expression of the activated leukocyte cell adhesion molecule (ALCAM) is associated with cancer progression in various cancer types. In some cancers ALCAM has a prognostic value or is predictive for the benefit of therapeutic interventions. To date there are no data on the role of ALCAM in cervical cancer available.

Methods
In this study, ALCAM expression was analysed by immunohistochemistry (IHC) in tissue samples of 233 patients with cervical cancer, among them 178 with complete follow-up information. In addition, soluble (s-)ALCAM was measured in sera of a subset of the included patients (n = 55) by enzyme-linked immunosorbent assay (ELISA).

Results
ALCAM overexpression was detected (immunoreactive score (IRS) 2-12) in 58.4% of the cervical cancer samples. The normal ectocervical or endocervical epithelium showed no ALCAM reactivity. In untreated patients, ALCAM overexpression in tumor tissue tended to be associated with shorter cancer-specific survival (CSS) and disease-free survival (DFS). Patients, whose tumor samples showed ALCAM overexpression receiving a cytotoxic therapy like radiotherapy or chemoradiation, however, had a favourable prognosis compared to those patients, whose cancers showed no or minimal ALCAM staining. This effect was particularly apparent in patients receiving chemoradiation where the CSS was significantly longer in patients with ALCAM-positive tumors (p = 0.038; cumulative incidence rates at 96 months 8%, 95% CI 0%-23%, and 26%, CI 3%-43% in ALCAM-positive and ALCAM-negative cases, respectively).
Median preoperative s-ALCAM concentration in sera from tumor patients was 27.6 ng/ml (range 17.5-55.1 ng/ml, mean 28.9 ng/ml), serum levels did not correlate with intratumoral ALCAM expression.

Conclusions
The data of our retrospective study suggest that the prognostic value of ALCAM expression in cervical carcinoma might be therapy-dependent, and that ALCAM might function as a predictive marker for the response to chemoradiation. This should be confirmed in further, prospective studies.