bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effects of Selling Formats and Upstream Competition on Product Pricing and Quality Design
Authors: Hsiao Lu , Ma Xin , Chen Ying-Ju 
Published: May 2024

Problem definition: In practice, consumers are directly or indirectly connected with branded manufacturers through intermediaries across industries. In this paper, we explore the effects of different selling formats on product quality and price depending on consumer valuations in a market. We employ a distribution family to comprehensively capture the heterogeneity of consumer valuations. Motivated by realistic phenomena, consumer valuations are used to investigate strategic decisions under different selling formats that are not trivial to analyze. Methodology/results: We develop game-theoretical models to examine the equilibrium decisions of stakeholders. The impact of consumer valuations is investigated and validated using sensitivity analysis, and the results are connected to practice. First, we find that agency selling induces a premium quality and maximizes the channel profit; remarkably, a nonmonotonic (approximate U-shaped) relationship exists between the agency fee and consumer valuations. A higher consumer surplus can be achieved in an agency selling channel compared with a reselling channel, particularly when targeting a mass of high-end consumers. Second, by examining distinct consumer valuations, maintaining top-notch quality and the highest price in an agency selling channel is not universally viable under some conditions. Third, in the case of production-level competition, an agency selling format tends to cause product quality to vary noticeably. Moreover, in the hybrid selling channel, in contrast to agency selling, the high-type manufacturer reduces both quality and price, which bolsters the overall profits of the channel and the consumer surplus. Managerial implications: Branded manufacturers can efficiently respond to individualized consumer needs in a centralized distribution channel. In contrast, for selling basic products, the reselling channel could contribute to achieving economies of scale and offering competitive prices. In the agency selling channel, standardized pricing determined by branded manufacturers can create a consistent perception of product quality throughout the distribution network. Funding: The research of L. Hsiao was supported by Ministry of Science and Technology (now National Science and Technology Council), Grant/Award Number: MOST 110-2410-H-005-016-MY3. The research of Y.-J. Chen was supported by the HK RGC General Research Fund [GRF 16500821, GRF 16501722, and HKUST C6020-21GF]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0470 .
Evaluation of the effects of health education interventions for hypertensive patients based on the health belief model
Authors: Wang Hong-Mei , Chen Ying , Shen Yan-Hua , Wang Xiao-Mei 
Published: May 2024

BACKGROUND
Hypertension is a major risk factor for cardiovascular disease and stroke, and its prevalence is increasing worldwide. Health education interventions based on the health belief model (HBM) can improve the knowledge, attitudes, and behaviors of patients with hypertension and help them control their blood pressure.
AIM
To evaluate the effects of health education interventions based on the HBM in patients with hypertension in China.
METHODS
Between 2021 and 2023, 140 patients with hypertension were randomly assigned to either the intervention or control group. The intervention group received health education based on the HBM, including lectures, brochures, videos, and counseling sessions, whereas the control group received routine care. Outcomes were measured at baseline, three months, and six months after the intervention and included blood pressure, medication adherence, self-efficacy, and perceived benefits, barriers, susceptibility, and severity.
RESULTS
The intervention group had significantly lower systolic blood pressure [mean difference (MD): -8.2 mmHg, P < 0.001] and diastolic blood pressure (MD: -5.1 mmHg, P = 0.002) compared to the control group at six months. The intervention group also had higher medication adherence (MD: 1.8, P < 0.001), self-efficacy (MD: 12.4, P < 0.001), perceived benefits (MD: 3.2, P < 0.001), lower perceived barriers (MD: -2.6, P = 0.001), higher perceived susceptibility (MD: 2.8, P = 0.002), and higher perceived severity (MD: 3.1, P < 0.001) than the control group at six months.
CONCLUSION
Health education interventions based on the HBM effectively improve blood pressure control and health beliefs in patients with hypertension and should be implemented in clinical practice and community settings.
Transparent cap adjusted the stent placed for stenosis after endoscopic injection of esophageal varices: A case report
Authors: Zhang Fu-Long , Xu Jing , Zhu Yuan-Dong , Wu Qian-Neng , Shi Yan , Fang Lei , Zhou Dan , Wang Hai , Huang Chao-Jun , Zhou Chun-Hua , Zhu Qun 
Published: May 2024

BACKGROUND
The stent embedded in the esophageal mucosa is one of the complications after stenting for esophageal stricture. We present a case of stent adjustment with the aid of a transparent cap after endoscopic injection of an esophageal varices stent.
CASE SUMMARY
A 61-year-old male patient came to the hospital with discomfort of the chest after the stent implanted for the stenosis because of endoscopic injection of esophageal varices. The gastroscopy was performed, and the stent embedded into the esophageal mucosa. At first, we pulled the recycling line for shrinking the stent, however, the mucosa could not be removed from the stent. Then a forceps was performed to remove the mucosa in the stent, nevertheless, the bleeding form the mucosa was obvious. And then, we used a transparent cap to scrape the mucosa along the stent, and the mucosa were removed successfully without bleeding.
CONCLUSION
A transparent cap helps gastroscopy to remove the mucosa embedded in the stent after endoscopic injection of the esophageal varices stent.
C634Y mutation in RET-induced multiple endocrine neoplasia type 2A: A case report
Authors: Zhang Hui-Fen , Huang Shu-Ling , Wang Wen-Li , Zhou Yu-Qing , Jiang Jun , Dai Zhuo-Jin 
Published: May 2024

BACKGROUND
Multiple endocrine neoplasia type 2 (MEN2) is a rare, autosomal dominant endocrine disease. Currently, the RET proto-oncogene is the only gene implicated in MEN2A pathogenesis. Once an RET carrier is detected, family members should be screened to enable early detection of medullary thyroid carcinoma, pheochromocytoma, and hyperparatitity. Among these, medullary thyroid carcinoma is the main factor responsible for patient mortality. Accordingly, delineating strategies to inform clinical follow-up and treatment plans based on genes is paramount for clinical practitioners.
CASE SUMMARY
Herein, we present RET proto-oncogene mutations, clinical characteristics, and treatment strategies in a family with MEN2A. A family study was conducted on patients diagnosed with MEN2A. DNA was extracted from the peripheral blood of family members, and first-generation exon sequencing of the RET proto-oncogene was conducted. The C634Y mutation was identified in three family members spanning three generations. Two patients were sequentially diagnosed with pheochromocytomas and bilateral medullary thyroid carcinomas. A 9-year-old child harboring the gene mutation was diagnosed with medullary thyroid carcinoma. Surgical resection of the tumors was performed. All family members were advised to undergo complete genetic testing related to the C634Y mutation, and the corresponding treatments administered based on test results and associated clinical guidelines.
CONCLUSION
Advancements in MEN2A research are important for familial management, assessment of medullary thyroid cancer invasive risk, and deciding surgical timing.
Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma: A case report
Authors: Luo Xin-Xin , Du Yu-Xuan , Zhang Qi-Qing , Zhang Lin , Zeng Shu-Ying , Yu Zhi-Hong , Shen Peng , Feng Zheng-Quan 
Published: May 2024

BACKGROUND
Multiple primary carcinomas (MPCs) are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same individual. Synchronous MPCs are rarer than solitary cancers or metachronous MPCs. Accurate diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these cases.
CASE SUMMARY
A 64-year-old patient presented with dysphagia, without obvious cause. A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory results. After multi-disciplinary consultations, combination chemotherapy (a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14) and esophageal cancer radiotherapy were initiated. Based on the results of genetic testing, we switched to a regimen of leucovorin + fluorouracil + oxaliplatin and cetuximab regimen for 8 cycles. Subsequently, capecitabine and bevacizumab were administered until the most recent follow-up, at which the tumor remained stable.
CONCLUSION
Successful cetuximab chemotherapy treatment provides a reference for the non-operative and homogeneous treatment of different pathological types of synchronous MCPs.
Exploring dietitians’ practice and perspectives on the role of dietary patterns during cancer treatment: A qualitative study
Authors: Curtis Annie R. , Kiss Nicole , Livingstone Katherine M. , Daly Robin M. , Ugalde Anna 
Published: May 2024

Background
Dietitians are nutrition professionals equipped with specialised skills required to prevent and treat malnutrition in cancer. Optimisation of dietary intake is recommended as the primary nutrition strategy for the treatment of cancer-related malnutrition. However, it is unclear whether dietary patterns, described as the combination, quantity, and frequency of food consumption, are considered. This study examined dietitians’ current food-based management of malnutrition; explored dietitians’ awareness of dietary patterns and assessed barriers and enablers to the use of dietary patterns in clinical practice.

Methods
This qualitative study consisted of semi-structured interviews with oncology dietitians. Dietitians were recruited through national nutrition societies, social media, and professional networks. Audio-recorded interviews were transcribed verbatim and analysed using inductive thematic analysis.

Results
Fourteen oncology dietitians from across four Australian states and territories participated. Three themes were identified: (i) principles to guide nutritional care, (ii) dietary patterns as a gap in knowledge and practice, and (iii) opportunities for better care with systems as both a barrier and enabler. Dietetic practice was food-focussed, encouraging energy and protein-rich foods consistent with nutrient-focussed evidence-based guidelines. Dietitians encouraged one of two nutrition-related approaches, either encouraging intake of ‘any tolerated food’ or ‘foods supportive on longer-term health’. Dietitians were generally unaware of dietary patterns and questioned their relevance in certain clinical situations. A multidisciplinary team approach, adequate food service and dissemination of dietary patterns research and education were identified as opportunities for better patient care.

Conclusions
Recommendations for the treatment of malnutrition vary between oncology dietitians and uncertainty exists regarding dietary patterns and their relevance in clinical practice. Further exploration into the role of dietary patterns to treat cancer-related malnutrition and education for dietitians are required prior to implementation of a dietary patterns approach into clinical practice.
Economic Burden of Eosinophilic Esophagitis: A Nationwide Cost-of-Illness Study
Authors: Bozorg Soran R. , Söderling Jonas , Mårild Karl , Garber John J. , Uchida Amiko , Neovius Martin , Ludvigsson Jonas F. , Everhov Åsa H. 
Published: May 2024

INTRODUCTION:
Despite its increasing prevalence, the economic impact of eosinophilic esophagitis (EoE) is understudied.

METHODS:
We estimated the societal economic burden of EoE by using real-world data from Swedish health registers.

RESULTS:
Patients with EoE had 45% higher societal cost ($6,290 vs $4,349) compared with the general population, primarily driven by increased healthcare costs ($2,414 vs $1,022), which accounted for 72% of the excess societal cost in EoE.

DISCUSSION:
EoE is associated with a considerable economic burden to society. With the prevalence of EoE still rising, the economic burden of EoE is expected to continue to grow.
Reciprocal inhibition of the thigh muscles in humans: A study using transcutaneous spinal cord stimulation
Authors: Nakagawa Kento , Kakehata Gaku , Kaneko Naotsugu , Masugi Yohei , Osu Rieko , Iso Shigeo , Kanosue Kazuyuki , Nakazawa Kimitaka 
Published: May 2024

AbstractEvaluating reciprocal inhibition of the thigh muscles is important to investigate the neural circuits of locomotor behaviors. However, measurements of reciprocal inhibition of thigh muscles using spinal reflex, such as H‐reflex, have never been systematically established owing to methodological limitations. The present study aimed to clarify the existence of reciprocal inhibition in the thigh muscles using transcutaneous spinal cord stimulation (tSCS). Twenty able‐bodied male individuals were enrolled. We evoked spinal reflex from the biceps femoris muscle (BF) by tSCS on the lumber posterior root. We examined whether the tSCS‐evoked BF reflex was reciprocally inhibited by the following conditionings: (1) single‐pulse electrical stimulation on the femoral nerve innervating the rectus femoris muscle (RF) at various inter‐stimulus intervals in the resting condition; (2) voluntary contraction of the RF; and (3) vibration stimulus on the RF. The BF reflex was significantly inhibited when the conditioning electrical stimulation was delivered at 10 and 20 ms prior to tSCS, during voluntary contraction of the RF, and during vibration on the RF. These data suggested a piece of evidence of the existence of reciprocal inhibition from the RF to the BF muscle in humans and highlighted the utility of methods for evaluating reciprocal inhibition of the thigh muscles using tSCS.
Antifungal, antioxidant, and photocatalytic activities of greenly synthesized iron oxide nanoparticles
Authors: Maniah Khalid 
Published: May 2024

AbstractThe build-up of synthetic dyes in the environment and aquatic ecology is a significant environmental issue due to their inability to break down naturally. The overuse of chemical fungicides also poses a threat to the environment due to their accumulation and fostering of fungal resistance. Hence, the study was conducted to detect the antifungal properties and photocatalytic activity of greenly synthesized iron oxide nanoparticles (IONPs) prepared using theHibiscus sabdariffaflower extract. The biogenic IONPs showed the highest photocatalytic activity against rhodamine B dye at a concentration of 4.0 mg/ml. The biogenic IONPs also demonstrated effective antifungal properties againstPenicillium digitatumandAspergillus nigerstrains, with relative inhibition percentages of mycelial growth being higher than those with the metalaxyl + mancozeb fungicide at 800 ppm concentration. The efficient photocatalytic activity of the biogenic IONPs against rhodamine B dye and their effective antifungal properties suggest their potential use as safe substitutes for commercial fungicides.
Effects of tumor necrosis factor-α rs1800629 and interleukin-10 rs1800872 genetic variants on type 2 diabetes mellitus susceptibility and metabolic parameters among Jordanians
Authors: Mousa Lana Nasrallah , Jarrar Yazun , Gharaibeh Munir , Alhawari Hussam 
Published: May 2024

Abstract

Objectives
Diabetes mellitus (DM) is a complex chronic illness with diverse pathogenesis and associations with health complications. Genetic factors significantly contribute to DM development, and tumor necrosis factor alpha (TNF-α) and interleukin-10 (IL-10) genes play major roles. This study aims to explore the influence of TNF-α rs1800629 and IL-10 rs1800872 genetic variants on T2DM development in Jordanian patients at Jordan University Hospital.

Methods
One-hundred and 60 diabetic and 159 non-diabetic subjects were genotyped for TNF-α rs1800629. Additionally, 181 diabetic and 191 non-diabetic subjects were genotyped for IL-10 rs1800872 using PCR-RFLP genotyping method. The demographic, lipid, and glycemic parameters of the patients were obtained from the computer records in the hospital.

Results

TNF-α rs1800629 and IL-10 rs1800872 genetic variants exhibited significant different frequencies in non-T2DM subjects and T2DM patients. The difference in TNF-α rs1800629 genotype frequency between non-T2DM and T2DM participants was significant under the dominant model, while the IL-10 rs1800872 genotype frequency was significant under the recessive model. A significant association (p<0.05) was observed between TNF-α rs1800629 and total cholesterol levels, and between IL-10 rs1800872 polymorphism and glycosylated hemoglobin (HbA1c) and creatinine levels among T2DM patients.

Conclusions

TNF-α rs1800629 and IL-10 rs1800872 are identified as genetic risk factors for T2DM. These variants also correlate with variations in cholesterol, HbA1c, and creatinine levels among T2DM patients. Larger clinical studies are warranted to validate these findings.
Coseismic slip model of the 14 January 2021 Mw 6.2 Mamuju-Majene earthquake based on static and kinematic GNSS solution
Authors: Prayoga Oktadi , Pratama Cecep 
Published: May 2024

Abstract
The Mw 6.2 Mamuju-Majene earthquake occurred on 14 January 2021, with the epicenter at 118.890°E, 2.972°S. The shaking caused severe damage in West Sulawesi, especially in the Mamuju and Majene cities. Most of the coseismic slip distribution of the Mamuju-Majene Earthquake is derived from the daily solutions, which might include early postseismic deformation. Therefore, we conducted a coseismic slip model using kinematic solution based on Global Navigation Satellite System (GNSS) to determine the best coseismic slip values and model distribution. Our analysis indicates that the coseismic displacement from the kinematic solution is higher than the static solution. The GNSS data was utilized for inversion analysis, considering two potential fault sources, they are the Makassar Strait Central Fault and the Mamuju Fault. We found a larger misfit between the observed data and the model generated on static and kinematic solutions along the Makassar Strait Central Fault. Based on the kinematic solution, the coseismic slip distribution represents that fault rupture spreading along a north-south orientation, while the static solution is centered in the northern part. The maximum coseismic slip from each kinematic and static solution is 0.29 m and 0.11 m, respectively. Meanwhile, the seismic moment generated from the kinematic solution is 1.5 × 1026 N m (equivalent to Mw 6.75), which is greater than the static solution of 2.4 × 1025 N m (equivalent to Mw 6.22).
A novel variant in the FLNB gene associated with spondylocarpotarsal synostosis syndrome
Authors: Qasim Hina , Khan Hayat , Zeb Humaira , Ahmad Akmal , Ilyas Muhammad , Zahoor Muhammad , Umar Muhammad Naveed , Ullah Riaz , Ali Essam A. 
Published: May 2024

Abstract

Objectives
Genetic disorders involved in skeleton system arise due to the disturbance in skeletal development, growth and homeostasis. Filamin B is an actin binding protein which is large dimeric protein which cross link actin cytoskeleton filaments into dynamic structure. A single nucleotide changes in the FLNB gene causes spondylocarpotarsal synostosis syndrome, a rare bone disorder due to which the fusion of carpels and tarsals synostosis occurred along with fused vertebrae. In the current study we investigated a family residing in north-western areas of Pakistan.

Methods
The whole exome sequencing of proband was performed followed by Sanger sequencing of all family members of the subject to validate the variant segregation within the family. Bioinformatics tools were utilized to assess the pathogenicity of the variant.

Results
Whole Exome Sequencing revealed a novel variant (NM_001457: c.209C>T and p.Pro70Leu) in the FLNB gene which was homozygous missense mutation in the FLNB gene. The variant was further validated and visualized by Sanger sequencing and protein structure studies respectively as mentioned before.

Conclusions
The findings have highlighted the importance of the molecular diagnosis in SCT (spondylocarpotarsal synostosis syndrome) for genetic risk counselling in consanguineous families.
Structural behavior of one-way slabs reinforced by a combination of GFRP and steel bars: An experimental and numerical investigation
Authors: Rasheed Mohammed Raed , Mohammed Shatha Dheyaa 
Published: May 2024

Abstract
Glass- fiber-reinforced polymer (GFRP) offers a significant alternative to steel in reinforced concrete, with superior corrosion and fire resistance. Though less ductile and more brittle in stress–strain behavior than steel, it is very helpful to combine GFRP with steel reinforcement that improves the structural behavior. This research investigates the flexural characteristics of a one-way slab reinforced by a combination of GFRP and steel reinforcement. Three identical concrete slabs ((1500 × 550 × 120) mm and 43 MPa) were tested under static load with GFRP replacement ratios of (0, 20, and 40)%. The experimental data were utilized to verify a numerical model. The experimental outcomes indicated a substantial impact of the GFRP replacement ratio on the failure mode. The failure mode was flexural, flexural-shear, and shear regarding the reference slab, 20%, and 40% replacement, respectively. GFRP replacement influenced ductility and ultimate load by (9.13 and 10.7)% and (−21 and 5.0)% for replacement ratio (20 and 40)%, respectively. Based on the numerical analysis, the parametric study (considerably affected the structural response. Failure mode changed to flexural, and shear-flexural concerning (20 and 40)%, respectively. The optimum load was characterized at 40%, while max toughness and ductility were achieved at 20%.
Minimization of dispersion and non-linear effects in WDM based long-haul high capacity optical communication systems
Authors: Zaman Zahid , Khan Yousaf , Khan Ammar Muhammad 
Published: May 2024

Abstract
Chromatic dispersion and nonlinear impairments pose challenges in high-capacity optical transmission systems, leading to signal distortions, channel interference and diminished the transmission performances. This paper explores the utilization of dispersion compensating fibers (DCF) using different schemes to mitigate the dispersion that accumulates along the length of a fiber in a 16 × 10 Gbps high-capacity long haul WDM system over a range of 500 km. When different wavelengths of light pulses are transmitted through an optical fiber, they experience varying speeds due to the refractive index’s wavelength dependency. As a result, the light pulses become temporally spread out as they travel through the fiber, and this dispersion persists throughout the fiber’s length. Considering non-linear effects such as self-phase modulation (SPM) and cross-phase modulation (XPM), this paper analyze and compare the three compensation schemes of DCF in a 16 channel WDM system. Moreover the impact of non-linearities based on fiber length are also analyzed and compared. The results are evaluated by comparing metrics such as Q-factor, bit error rate (BER) and eye height. The analysis concludes that the symmetrical compensation scheme of DCF outperforms the pre- and post-compensation scheme. This finding suggests that the symmetrical compensation method offers a promising solution for high-capacity access networks, providing high spectral efficiency, cost-effectiveness, and improved flexibility.