bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacodynamic Effects of Concomitant Versus Staggered Clopidogrel and Omeprazole Intake
Authors: Ferreiro José L. , Ueno Masafumi , Capodanno Davide , Desai Bhaloo , Dharmashankar Kodlipet , Darlington Andrew , Charlton Ronald K. , Bass Theodore A. , Angiolillo Dominick J. 
Published: September 2010

Background—
A drug interaction between clopidogrel and omeprazole resulting in impaired platelet inhibition has been reported. It has been suggested that staggering administration of clopidogrel and omeprazole may overcome this pharmacodynamic (PD) interaction.

Methods and Results—

This prospective, open-label, 3-period, randomized crossover study was performed in 20 healthy volunteers. Subjects were randomly selected to receive omeprazole (40 mg daily) concomitantly (CONC) or staggered by 8 to 12 hours (STAG) for 1 week on a background of clopidogrel therapy in a crossover fashion, with a 2- to 4-week washout period between treatments. After another 2- to 4-week washout period, all subjects were treated for 1 week with clopidogrel alone. Clopidogrel was administered as a 600-mg loading dose followed by a 75-mg maintenance dose during all phases. PD effects were assessed by vasodilator-stimulated phosphoprotein phosphorylation assay, VerifyNow P2Y
12
system, and light transmittance aggregometry at baseline, 24 hours, and 1 week. The primary end point was the comparison of P2Y
12
reactivity index assessed by vasodilator-stimulated phosphoprotein phosphorylation assay at 1 week between CONC and STAG regimens. No significant difference in the primary end point was observed (least squares mean±SEM, 56.1±3.5% for CONC versus 61.6±3.4% for STAG;
P
=0.08). P2Y
12
reactivity index values were significantly lower in the clopidogrel regimen (48.8±3.4%) than in the CONC (
P
=0.02) and STAG (
P
=0.001) regimens. No PD differences were observed between regimens at baseline and 24 hours. Concordant results were obtained by P2Y
12
-specific assessments using VerifyNow but not with light transmittance aggregometry.

Conclusions—
Omeprazole impairs clopidogrel-induced antiplatelet effects in the maintenance phase of treatment irrespective of timing of their administration.
DTCA of Prescription Medicines in the European Union: Is There Still a Need for a Ban?
Authors: Poser Mareen 
Published: September 2010

AbstractThe pharmaceutical sector is one of the main markets in the European Union. The consumption of medicines is high and steadily increasing. However, the pharmaceutical market is subject to a wider range of restrictions than almost any other sector. The restrictions mainly apply to information provision and advertising practice within the community. One of the main features in pharmaceutical regulation is the ban on direct-to-consumer advertising (DTCA) of prescription medicines. However, an abolition of the ban is controversial in the European Community, especially as the pharmaceutical industry keeps pleading for its ability to use the highly effective marketing strategy of DTCA to promote prescription medicines to the general public. Such advertising is only allowed in two jurisdictions in the world, New Zealand and the United States. In both systems the impact of DTCA on the consumer and the economy has been subject to research. The outcome of these studies is outlined in this article. Since the European Commission has provided a new proposal to amend the current information practice regarding prescription medicines in 2008 (European Commission, Proposal for a Directive of the European Parliament and of the Council Amending, as Regards Information to the General Public on Medicinal Products Subject to Medical Prescription, Directive 2001/83/EC on the Community Code Relating to Medicinal Products for Human Use, COM/2008/0663 final) it is time to examine different options to regulate the provision of information and discuss the need for a ban of DTCA.
End of Life Decisions and Pregnant Women: Do Pregnant Women Have the Right to Refuse Life Preserving Medical Treatment? A Comparative Study
Authors: Lemmens Christophe 
Published: September 2010

AbstractIn this article the practice of end of life decisions is applied to pregnant women. This is not an easy task as shown by the extensive case law and literature on the subject. The main conclusion of the article is that the pregnant woman's wishes should always be respected whatever the consequences for the foetus may be. Another position would unjustly sacrifice the woman's fundamental rights to bodily integrity and self-determination for the benefit of a non-person. The result is repeated in the situation where the woman is found to be incompetent or brain dead.
Estimating Climatically Relevant Singular Vectors for Decadal Predictions of the Atlantic Ocean
Authors: Hawkins Ed , Sutton Rowan 
Published: September 2010

Abstract
A key aspect in designing an efficient decadal prediction system is ensuring that the uncertainty in the ocean initial conditions is sampled optimally. Here one strategy for addressing this issue is considered by investigating the growth of optimal perturbations in the third climate configuration of the Met Office Unified Model (HadCM3) global climate model (GCM). More specifically, climatically relevant singular vectors (CSVs)—the small perturbations of which grow most rapidly for a specific set of initial conditions—are estimated for decadal time scales in the Atlantic Ocean. It is found that reliable CSVs can be estimated by running a large ensemble of integrations of the GCM. Amplification of the optimal perturbations occurs for more than 10 yr, and possibly up to 40 yr. The identified regions for growing perturbations are found to be in the far North Atlantic, and these perturbations cause amplification through an anomalous meridional overturning circulation response. Additionally, this type of analysis potentially informs the design of future ocean observing systems by identifying the sensitive regions where small uncertainties in the ocean state can grow maximally. Although these CSVs are expensive to compute, ways in which the process could be made more efficient in the future are identified.
An Atmospheric Teleconnection Linking ENSO and Southwestern European Precipitation
Authors: Shaman Jeffrey , Tziperman Eli 
Published: September 2010

Abstract
Numerous studies have demonstrated statistical associations between the El Niño–Southern Oscillation (ENSO) and precipitation in the Mediterranean basin. The dynamical bases for these teleconnections have yet to be fully identified. Here, observational analyses and model simulations are used to show how ENSO variability affects rainfall over southwestern Europe (Iberia, Southern France, and Italy). A precipitation index for the region, named southwestern European Precipitation (SWEP), is used. The observational analyses show that ENSO modulates SWEP during the September–December wet season. These precipitation anomalies are associated with changes in large-scale atmospheric fields to the west of Iberia that alter low-level westerly winds and onshore moisture advection from the Atlantic.
The vorticity anomalies associated with SWEP variability are linked to ENSO through a stationary barotropic Rossby wave train that emanates from the eastern equatorial Pacific and propagates eastward to the Atlantic and Mediterranean. Solutions of the linearized barotropic vorticity equation produce such eastward-propagating Rossby waves with trajectories that traverse the region of observed ENSO-related anomalies. In addition, these linearized barotropic vorticity equation solutions produce a dipole of positive and negative vorticity anomalies to the west of Iberia that matches observations and is consistent with the onshore advection of moisture. Thus, interannual variability of fall and early winter precipitation over southwestern Europe is linked to ENSO variability in the eastern Pacific via an eastward-propagating atmospheric stationary barotropic Rossby wave train.
Optimal Excitation of Interannual Atlantic Meridional Overturning Circulation Variability
Authors: Zanna Laure , Heimbach Patrick , Moore Andrew M. , Tziperman Eli 
Published: September 2010

Abstract
The optimal excitation of Atlantic meridional overturning circulation (MOC) anomalies is investigated in an ocean general circulation model with an idealized configuration. The optimal three-dimensional spatial structure of temperature and salinity perturbations, defined as the leading singular vector and generating the maximum amplification of MOC anomalies, is evaluated by solving a generalized eigenvalue problem using tangent linear and adjoint models. Despite the stable linearized dynamics, a large amplification of MOC anomalies, mostly due to the interference of nonnormal modes, is initiated by the optimal perturbations.
The largest amplification of MOC anomalies, found to be excited by high-latitude deep density perturbations in the northern part of the basin, is achieved after about 7.5 years. The anomalies grow as a result of a conversion of mean available potential energy into potential and kinetic energy of the perturbations, reminiscent of baroclinic instability. The time scale of growth of MOC anomalies can be understood by examining the time evolution of deep zonal density gradients, which are related to the MOC via the thermal wind relation. The velocity of propagation of the density anomalies, found to depend on the horizontal component of the mean flow velocity and the mean density gradient, determines the growth time scale of the MOC anomalies and therefore provides an upper bound on the MOC predictability time.
The results suggest that the nonnormal linearized ocean dynamics can give rise to enhanced MOC variability if, for instance, overflows, eddies, and/or deep convection can excite high-latitude density anomalies in the ocean interior with a structure resembling that of the optimal perturbations found in this study. The findings also indicate that errors in ocean initial conditions or in model parameterizations or processes, particularly at depth, may significantly reduce the Atlantic MOC predictability time to less than a decade.
Characteristics of the Beaufort Sea High
Authors: Serreze Mark C. , Barrett Andrew P. 
Published: September 2010

Abstract
Characteristics of the Arctic Ocean’s Beaufort Sea high are examined using fields from the NCEP–NCAR reanalysis. At a 2-hPa contour interval, the Beaufort Sea high appears as a closed anticyclone in the long-term annual mean sea level pressure field and in spring. In winter, the Beaufort Sea region is influenced by a pressure ridge at sea level extending from the Siberian high to the Yukon high over northwestern Canada. As assessed from 6-hourly surface winds, the mean frequency of anticyclonic surface winds over the Beaufort Sea region is fairly constant through the year. While for all seasons a strong closed high can be interpreted as the surface expression of an amplified western North American ridge at 500 hPa, there is some suggestion of a split flow, where the ridge linked to the surface high is separated from the ridge to the south that lies within the main belt of westerlies. The Aleutian low in the North Pacific tends to be deeper than normal when there is a strong Beaufort Sea high. In all seasons but autumn, a strong Beaufort Sea high is associated with positive lower-tropospheric temperature anomalies covering much of the Arctic Ocean; positive anomalies are especially pronounced in spring. Seasons with a weak anticyclone show broadly opposing anomalies. A strong high is found to be a feature of the negative phase of the summer northern annular mode, the positive phase of the Pacific–North American wave train, and, to a weaker extent, the positive phase of the summer Arctic dipole anomaly and Pacific decadal oscillation. The unifying theme is that, to varying degrees, the high-latitude 500-hPa ridge associated with the Beaufort Sea high represents a center of action in each teleconnection pattern.
Scale Interaction of the Diurnal Cycle of Rainfall over the Maritime Continent and Australia: Influence of the MJO
Authors: Rauniyar Surendra P. , Walsh Kevin J. E. 
Published: September 2010

Abstract
The influence of the MJO on the phase and amplitude of the diurnal cycle of rainfall during Australian summer [December–February (DJF)] over the Maritime Continent (MC) and northern Australia is investigated using the Tropical Rainfall Measuring Mission (TRMM) 3B42 and 3G68 datasets. The gridded rainfall was partitioned into MJO categories (active, suppressed, and weak) based on their longitudinal position and by utilizing the real-time multivariate MJO (RMM) index of Wheeler and Hendon. The diurnal cycles were composited and an empirical orthogonal function (EOF) analysis was applied to extract the spatial and temporal variability.
Distinct variations in the rainfall distribution pattern among categories of the MJO over land and ocean are seen. The result of the composite-mean rainfall distribution shows that the average daily rainfall rate over islands is higher during suppressed MJO days, while for surrounding oceans and northern regions of Australia, more rainfall occurs during MJO active days. The normalized relative amplitude (NRA) of the diurnal cycle of rainfall shows that morning rainfall near coastal areas during active days of the MJO is 1.5 times greater than the climatological-mean rainfall but is less than or equal to the climatological mean during other phases of the MJO. Similarly, during the suppressed phase of the MJO evening rainfall is greater over the islands than in other MJO phases. The first two modes of the EOF alone explain more than 88% (65%) of the variance for the 3B42 (3G68) rainfall, and the corresponding principal component time series show a marked diurnal cycle. The results show that both the amplitude and phase of the diurnal cycle of rainfall are modulated by the categories of the MJO. In general, the peak in the diurnal cycle for active (suppressed/weak) days of the MJO lags (leads) the peak in the diurnal cycle for total rainfall by 2 h. Over Darwin and its adjacent regions, the active phase of the MJO is responsible for the occurrence of maximum rainfall after midnight, which is unusual in this region.
Persistence and Inherent Predictability of Arctic Sea Ice in a GCM Ensemble and Observations
Authors: Blanchard-Wrigglesworth Edward , Armour Kyle C. , Bitz Cecilia M. , DeWeaver Eric 
Published: September 2010

Abstract
The temporal characteristics of Arctic sea ice extent and area are analyzed in terms of their lagged correlation in observations and a GCM ensemble. Observations and model output generally match, exhibiting a red-noise spectrum, where significant correlation (or memory) is lost within 2–5 months. September sea ice extent is significantly correlated with extent of the previous August and July, and thus these months show a predictive skill of the summer minimum extent. Beyond this initial loss of memory, there is an increase in correlation—a reemergence of memory—that is more ubiquitous in the model than observations. There are two distinct modes of memory reemergence in the model. The first, a summer-to-summer reemergence arises within the model from the persistence of thickness anomalies and their influence on ice area. The second, which is also seen in observations, is associated with anomalies in the growth season that originate in the melt season. This reemergence stems from the several-month persistence of SSTs. In the model memory reemergence is enhanced by the sea ice albedo feedback. The same mechanisms that give rise to reemergence also enhance the 1-month lagged correlation during summer and winter. The study finds the least correlation between successive months when the sea ice is most rapidly advancing or retreating.
Diagnosis of Local Land–Atmosphere Feedbacks in India
Authors: Tuinenburg O. A. , Hutjes R. W. A. , Jacobs C. M. J. , Kabat P. 
Published: September 2010

AbstractFollowing the convective triggering potential (CTP)–humidity index (HIlow) framework by Findell and Eltahir, the sensitivity of atmospheric convection to soil moisture conditions is studied for India. Using the same slab model as Findell and Eltahir, atmospheric conditions in which the land surface state affects convective precipitation are determined. For India, CTP–HIlow thresholds for land surface–atmosphere feedbacks are shown to be slightly different than for the United States.Using atmospheric sounding data from 1975 to 2009, the seasonal and spatial variations in feedback strength have been assessed. The patterns of feedback strengths thus obtained have been analyzed in relation to the monsoon timing. During the monsoon season, atmospheric conditions where soil moisture positively influences precipitation are present about 25% of the time. During onset and retreat of the monsoon, the south and east of India show more potential for feedbacks than the north. These feedbacks suggest that large-scale irrigation in the south and east may increase local precipitation.To test this, precipitation data (from 1960 to 2004) for the period about three weeks just before the monsoon onset date have been studied. A positive trend in the precipitation just before the monsoon onset is found for irrigated stations. It is shown that for irrigated stations, the trend in the precipitation just before the monsoon onset is positive for the period 1960–2004. For nonirrigated stations, there is no such upward trend in this period. The precipitation trend for irrigated areas might be due to a positive trend in the extent of irrigated areas, with land–atmosphere feedbacks inducing increased precipitation.
Wave- and Anemometer-Based Sea Surface Wind (WASWind) for Climate Change Analysis*
Authors: Tokinaga Hiroki , Xie Shang-Ping 
Published: September 2010

Abstract
Ship-based measurements of sea surface wind speed display a spurious upward trend due to increases in anemometer height. To correct this bias, the authors constructed a new sea surface wind dataset from ship observations of wind speed and wind wave height archived in the International Comprehensive Ocean–Atmosphere Data Set (ICOADS). The Wave- and Anemometer-based Sea surface Wind (WASWind) dataset is available for wind velocity and scalar speed at monthly resolution on a 4° × 4° longitude–latitude grid from 1950 to 2008. It substantially reduces the upward trend in wind speed through height correction for anemometer-measured winds, rejection of spurious Beaufort winds, and use of estimated winds from wind wave height. The reduced global upward trend is smallest among the existing global datasets of in situ observations and comparable with those of reanalysis products. Despite the significant reduction of globally averaged wind speed trend, WASWind features rich spatial structures in trend pattern, making it a valuable dataset for studies of climate changes on regional scales. Not only does the combination of ship winds and wind wave height successfully reproduce major modes of seasonal-to-decadal variability; its trend patterns are also physically consistent with sea level pressure (SLP) measurements. WASWind is in close agreement with wind changes in satellite measurements by the Special Sensor Microwave Imagers (SSM/Is) for the recent two decades. The agreement in trend pattern with such independent observations illustrates the utility of WASWind for climate trend analysis. An application to the South Asian summer monsoon is presented.
Large-Scale Climate Controls of Interior Alaska River Ice Breakup
Authors: Bieniek Peter A. , Bhatt Uma S. , Rundquist Larry A. , Lindsey Scott D. , Zhang Xiangdong , Thoman Richard L. 
Published: September 2010

AbstractFrozen rivers in the Arctic serve as critical highways because of the lack of roads; therefore, it is important to understand the key mechanisms that control the timing of river ice breakup. The relationships between springtime Interior Alaska river ice breakup date and the large-scale climate are investigated for the Yukon, Tanana, Kuskokwim, and Chena Rivers for the 1949–2008 period. The most important climate factor that determines breakup is April–May surface air temperatures (SATs). Breakup tends to occur earlier when Alaska April–May SATs and river flow are above normal. Spring SATs are influenced by storms approaching the state from the Gulf of Alaska, which are part of large-scale climate anomalies that compare favorably with ENSO. During the warm phase of ENSO fewer storms travel into the Gulf of Alaska during the spring, resulting in a decrease of cloud cover over Alaska, which increases surface solar insolation. This results in warmer-than-average springtime SATs and an earlier breakup date. The opposite holds true for the cold phase of ENSO. Increased wintertime precipitation over Alaska has a secondary impact on earlier breakup by increasing spring river discharge. Improved springtime Alaska temperature predictions would enhance the ability to forecast the timing of river ice breakup.
The Atmospheric Circulation over the North Atlantic as Induced by the SST Field
Authors: Feliks Yizhak , Ghil Michael , Robertson Andrew W. 
Published: September 2010

AbstractSpectral analyses of the sea surface temperature (SST) in the Simple Ocean Data Analysis (SODA) reanalysis for the past half-century identify prominent and statistically significant interannual oscillations in two regions along the Gulf Stream front over the North Atlantic. A model of the atmospheric marine boundary layer coupled to a baroclinic quasigeostrophic model of the free atmosphere is then forced with the SST history from the SODA reanalysis. Two extreme states are found in the atmospheric simulations: 1) an eastward extension of the westerly jet associated with the front, which occurs mainly during boreal winter, and 2) a quiescent state of very weak flow found predominantly in the summer. This vacillation of the oceanic-front-induced jet in the model is found to exhibit periodicities similar to those identified in the observed Gulf Stream SST front itself. In addition, a close correspondence is found between interannual spectral peaks in the observed North Atlantic Oscillation (NAO) index and the SODA-induced oscillations in the atmospheric model. In particular, significant oscillatory modes with periods of 8.5, 4.2, and 2.8 yr are found in both observed and simulated indices and are shown to be highly synchronized and of similar energy in both time series. These oscillatory modes in the simulations are shown to be suppressed when either (i) the Gulf Stream front or (ii) its interannual oscillations are omitted from the SST field. Moreover, these modes also disappear when (iii) the SST front is spatially smoothed, thus confirming that they are indeed induced by the oceanic front.