bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for Pneumocystis jirovecii pneumonia in kidney transplant recipients and appraisal of strategies for selective use of chemoprophylaxis
Authors: de Boer M.G.J. , Kroon F.P. , le Cessie S. , de Fijter J.W. , van Dissel J.T. 
Published: June 2011

M.G.J. de Boer, F.P. Kroon, S. le Cessie, J.W. de Fijter, J.T. van Dissel. Risk factors for Pneumocystis jirovecii pneumonia in kidney transplant recipients and appraisal of strategies for selective use of chemoprophylaxis. Transpl Infect Dis 2011: 13: 559–569. All rights reserved
Abstract: Risk stratification‐based duration of trimethoprim‐sulfamethoxazole (TMP‐SMX) chemoprophylaxis to prevent Pneumocystis pneumonia (PCP) in kidney transplant recipients is not a universally adapted strategy and supporting evidence‐based sources are limited. We performed a large retrospective study to identify risk factors for PCP in kidney transplant recipients and to define parameters for use in clinical prophylaxis guidelines. Fifty consecutive patients with confirmed PCP and 2 time‐matched controls per case were enrolled. All patients were participants of the kidney transplantation program of the Leiden University Medical Center, a tertiary care hospital in the Netherlands. Potential risk factors were compared between groups by uni‐ and multivariate matched analyses. At transplantation, age >55 years (adjusted odds ratio [OR] 2.7, 95% confidence interval [CI] 1.3–5.9) and not receiving basiliximab induction therapy (adjusted OR 4.3, 95% CI 1.1–17.1) predicted development of PCP. In the final multivariate analysis, only cytomegalovirus infection (adjusted OR 3.0, 95% CI 1.2–7.9) and rejection treatment (adjusted OR 5.8, 95% CI 1.9–18) were found to be independently associated with PCP. Using the variables identified by the multivariate analyses, effects of different hypothetical chemoprophylaxis strategies were systematically evaluated. Exploring different scenarios showed that chemoprophylaxis in the first 6 months for all renal transplant patients – and during the first year posttransplantation for patients >55 years of age or those treated for rejection – would result in very low PCP incidence and optimal avoidance of TMP‐SMX toxicity. The results provide a rationale for further prospective study on targeted provision of chemoprophylaxis to prevent PCP in kidney transplant patients.
Physiological and blood biochemical variables in horses exercising on a treadmill submerged in water
Authors: Lindner A. , Wäschle S. , Sasse H. H. L. 
Published: June 2011

SummaryThe blood lactate concentration (LA) and heart rate (HR) of 10 horses exercising in water on a treadmill were examined. With the water at 10 and 50% of the withers height (WH), the blood LA increased up to mean values around 1.9 mmduring the standardized exercise test (SET) until after step 3 of 5 (each step lasted 5 min, speed increasing step by step). Thereafter, blood LA of horses remained constant, while with the water at 80% of WH, the blood LA decreased from the mean peak of 2.16 ± 0.62 mmafter the 4th step. The HR of the horses increased to 132 ± 14 beats/min until the 3rd step of SET with the water at 10% of WH, up to the 2nd step with the water at 50% (134 ± 10 beats/min) and up to the 1st step only with the water at 80% of WH (134 ± 10 beats/min). In another SET, horses were exercised five times for 5 min at the maximal attainable speed of 5.5 m/s in water at 20% of the withers height in step 1, 35% in step 2, 49% in step 3, 63% in step 4 and 77% in step 5. On using this SET, blood LA increased to 1.91 ± 0.25 mmuntil after the 2nd step and decreased after the 3rd step. The HR increased between before commencing SET and the 1st step (143 ± 13 beats/min) and remained constant thereafter. In conclusion, increasing water height and speed of exercise does not augment continuously blood LA and HR of horses exercising in water treadmills.
Predictive factors of depression among Asian female marriage immigrants in Korea
Authors: Kim Jung A. , Yang Sook Ja , Kwon Kyoung Ja , Kim Jee Hee 
Published: June 2011

AbstractThis study investigated the prevailing rate of depression in female marriage immigrants in Korea and the predictive factors of their rates of depression. The study included 316 foreign female marriage immigrant participants. Four instruments yielded the data: the Center for Epidemiologic Studies Depression Scale and Multidimensional Scale of Perceived Social Support and questionnaires regarding the participants' Korean language ability and demographic data. The survey scales were translated into Korean, Vietnamese, Chinese, and English. The data collection was conducted by a face‐to‐face interview and translators were used when needed. The female marriage immigrants were found to have higher depression rates than women in the general Korean population. The predictive factors of depression for the female marriage immigrants included their country of origin, Korean speaking ability, and family support. Far more depression was found to occur in the Chinese participants, while the rate of depression was lower in those with competent Korean speaking ability and family support. An exploration of strategies to improve the speaking ability and family support of female marriage immigrants will be necessary in order to decrease their incidence of depression and the strategies should be differentiated based on the female marriage immigrants' country of origin.
Determining the relative roles of species replacement and species richness differences in generating beta‐diversity patterns
Authors: Carvalho José C. , Cardoso Pedro , Gomes Pedro 
Published: June 2011

ABSTRACTAim  To determine the relative contribution of species replacement and species richness differences to the emergence of beta‐diversity patterns.Innovation  A novel method that disentangles all compositional differences (βcc, overall beta diversity) in its two components, species replacement (β‐3) and species richness differences (βrich) is proposed. The performance of the method was studied with ternary plots, which allow visualization of the influence of the relative proportions of shared and unique species of two sites over each metric. The method was also tested in different hypothetical gradients and with real datasets. The novel method was compared with a previous proposal based on the partitioning of overall compositional differences (βsor) in replacement (βsim) and nestedness (βnes). The linear response of βcc contrasts with the curvilinear response of βsor to linear gradients of dissimilarity. When two sites did not share any species, βsim was always 1 and β‐3 only reached 1 when the number of exclusive species of both sites was equal. β‐3 remained constant along gradients of richness differences with constant replacement, while βsim decreased. βrich had a linear response to a linear gradient of richness differences with constant species replacement, whereas βnes exhibited a hump‐shaped response. Moreover, βsim > βnes when clearly almost all species of one site were lost, whereas β‐3 < βrich in the same circumstances.Main conclusions  The behaviour of the partition of βcc into β‐3 and βrich is consistent with the variation of replacement and richness differences. The partitioning of βsor into βsim and βnes overestimates the replacement component and underestimates richness differences. The novel methodology allows the discrimination of different causes of beta‐diversity patterns along latitudinal, biogeographic or ecological gradients, by estimating correctly the relative contributions of replacement and richness differences.
The scutellar vascular bundle–specific promoter of the wheat HD‐Zip IV transcription factor shows similar spatial and temporal activity in transgenic wheat, barley and rice
Authors: Kovalchuk Nataliya , Wu Wei , Eini Omid , Bazanova Natalia , Pallotta Margaret , Shirley Neil , Singh Rohan , Ismagul Ainur , Eliby Serik , Johnson Alexander , Langridge Peter , Lopato Sergiy 
Published: June 2011

SummaryAn HD‐Zip IV gene from wheat, TaGL9, was isolated using a Y1H screen of a cDNA library prepared from developing wheat grain. TaGL9 has an amino acid sequence distinct from other reported members of the HD‐Zip IV family. The 3′ untranslated region of TaGL9 was used as a probe to isolate a genomic clone of the TaGL9 homologue from a BAC library prepared from Triticum durum L. cv. Langdon. The full‐length gene containing a 3‐kb‐long promoter region was designated TdGL9H1. Spatial and temporal activity of TdGL9H1 was examined using promoter‐GUS fusion constructs in transgenic wheat, barley and rice plants. Whole‐mount and histochemical GUS staining patterns revealed grain‐specific expression of TdGL9H1. GUS expression was initially observed between 3 and 8 days after pollination (DAP) in embryos at the globular stage and adjacent to the embryo fraction of the endosperm. Expression was strongest in the outer cell layer of the embryo. In developed wheat and barley embryos, strong activity of the promoter was only detected in the main vascular bundle of the scutellum, which is known to be responsible for the uptake of nutrients from the endosperm during germination and the endosperm‐dependent phase of seedling development. Furthermore, this pattern of GUS staining was observed in dry seeds several weeks after harvesting but quickly disappeared during imbibition. The promoter of this gene could be a useful tool for engineering of early seedling vigour and protecting the endosperm to embryo axis pathway from pathogens during grain desiccation and storage.
China’s Foreign Trade: Perspectives From the Past 150 Years
Authors: Keller Wolfgang , Li Ben , Shiue Carol H. 
Published: June 2011

AbstractThis paper studies the trade of China in the past 150 years, starting from the first opening of China after the Opium War. The main purpose of the paper is to identify what is (and was) China’s ‘normal’ level of foreign trade, and how these levels changed under different trade regimes, from 1840 to the present. We present new evidence on China’s foreign trade during the treaty port era (1842–1948), drawn from disaggregated trade data collected by the Chinese Maritime Customs Service, that yields important findings for current research. First, although the volume of foreign trade remained limited initially, there was a notable expansion in the diversity of products, with many new goods being imported into China. Second, the regional diffusion of foreign goods through China was greatly facilitated by the expansions of the port system. Third, the importance of Hong Kong as an intermediary in China’s trade has undergone long‐term fluctuations suggestive of learning effects. China’s recent wave of liberalization has led by the early 1990s to a trade level comparable to the high of the 1920s. While much of China’s recent growth in world trade is in line with her income growth, there is no doubt that China’s trade openness today, comparable by some measures to Denmark’s, is a stunning reversal relative to the pre‐1978 and also the pre‐1840 period. The paper emphasises the roles that history and institutional change have played in this.
The ‘Real’ Impact of GATT/WTO – a Generalised Approach
Authors: Herz Bernhard , Wagner Marco 
Published: June 2011

AbstractRose’s result in 2004 that GATT/WTO has no significant impact on bilateral trade triggered off a series of empirical studies. Each of those studies augments Rose’s paper in one specific methodological aspect with the general finding that GATT/WTO significantly fosters members’ trade, although the estimated impact varies between 2 per cent and 195 per cent of trade creation. We combine the methodological contributions of previous studies to overcome these isolated approaches, to account for possible interactions and to develop a more general view on the impact of GATT/WTO. In particular, we find that GATT/WTO promotes members’ trade by around 86 per cent.
Airborne contact dermatitis to tetrazepam in geriatric nurses – a report of 10 cases
Authors: Landeck L. , Skudlik C. , John S.M. 
Published: June 2011

AbstractBackground  Tetrazepam, a benzodiazepine, is a frequently used muscle relaxant. The most common adverse reactions are neurological and gastrointestinal. Cutaneous reactions to tetrazepam are rare and occur predominantly after systemic administration.Objective  To present 10 health care professionals who developed airborne contact dermatitis to tetrazepam due to occupational exposure to tetrazepam dusts.Materials and methods  We report a series of 10 cases observed in our department between January 2006 and March 2011 where tetrazepam was identified to cause allergic airborne contact dermatitis. Affected individuals were employed as (geriatric) nursing staff, exposed to tetrazepam on a regular occupational basis when crushing tablets for their patients. Upon investigation, patients were patch tested with commercial and customized allergens. This included tetrazepam and in five cases diazepam. Tetrazepam revealed strong positive reactions in all patients. Additional diazepam sensitization was observed in three subjects. Following local treatment and occupational preventive action, patients recovered from their skin symptoms.Conclusions  Allergic contact sensitization to tetrazepam and cross‐sensitization to diazepam seems to be underestimated and not appropriately diagnosed in patch test clinics, as it is so far insufficiently patch tested. They should be considered when allergic contact dermatitis is suspected, particularly in professionally exposed staff, and tested as supplemental allergens.
Sun behaviour patterns and perception of illness among melanoma patients
Authors: Živković M.V. , Dediol I. , Ljubičić I. , Šitum M. 
Published: June 2011

AbstractBackground  Melanoma is one of the most aggressive skin tumours for which the major risk factor is ultraviolet radiation. Sun protection is extremely important, especially for melanoma patients who, once diagnosed with melanoma, have 500 times greater chance of developing another melanoma than the general population.Objective  In this study, we examined the perception of melanoma and attitudes towards sun protection among melanoma patients and compared their results with the patients suffering from other dermatological disorders.Methods  In total, 240 participants were included in the study: 120 patients suffering from melanoma and 120 participants in the control group. The Sun Behaviour Patterns Questionnaire and the Brief Illness Perceptions Questionnaire were used in this study to assess sun behaviours and perception of melanoma.Results  Melanoma patients have negative attitude towards sunbathing: 57% avoid sunbathing and 27% spend time in the sun only during swimming, otherwise seeking shade, whereas participants in the control group have more positive attitude towards sunbathing. Results indicate very short time of using sunscreen protection during the year and very small number of people using adequate SPF value, in both melanoma and control group.Conclusion  Participants in control group perceive melanoma as a more serious illness than patients who think that melanoma has mild symptoms, is easy to cure and control, has moderate consequences and lasts relatively long. Both melanoma patients and participants in the control group show relatively good sun behaviour patterns and slightly negative attitudes towards sun protection.
The effect of culture on consumer choice: the need for conformity vs. the need for uniqueness
Authors: Liang Beichen , He Yanbin 
Published: June 2011

AbstractThis paper investigates whether East Asians are more likely than Westerners to purchase a brand presented as a best‐seller given that East Asians tend to have a higher need for conformity and Westerners tend to have a higher need for uniqueness. Results show that East Asians are more likely than their Western counterparts to purchase such brands when the perceived risk is low. However, when the perceived risk is high, both East Asians and Westerners tend to prefer a brand presented as a best‐seller. Results also show that, in a three‐option set in which the C option is dominated by the B option but not by the A, both East Asians and Westerners are more likely to select option C when it is presented as a best‐seller than when it is not. Managerial implications and the study's limitations are also discussed.
Phylogenetic isolation increases plant success despite increasing susceptibility to generalist herbivores
Authors: Parker John D. , Burkepile Deron E. , Lajeunesse Marc J. , Lind Eric M. 
Published: June 2011

AbstractAim Theory suggests that introduced species that are phylogenetically distant from their recipient communities should be more successful than closely related introduced species because they can exploit open niches and escape enemies in their new range, i.e. Darwin’s Naturalization Hypothesis. Alternatively, it has also been hypothesized that closely related invaders might be more successful than novel invaders because they are pre‐adapted to conditions in their new range; a paradox coined Darwin’s Naturalization Conundrum. To date, these hypotheses have been tested primarily at the regional scale, not within local plant communities where introduced species colonize, compete and encounter herbivores.Location Global.Methods and Results We used community phylogenetics to analyse data from 49 published experiments to examine the importance of phylogenetic relatedness and generalist herbivory on native and exotic plant success at the community level. Plants that were categorized as ‘invasive’ were indeed less related to the recipient community than ‘non‐pest’ exotic plants. Distantly related exotic plants were also more abundant than closely related species. Phylogenetic relatedness predicted herbivore impact, but in a way that was opposite to predictions, as herbivores had stronger, not lesser, impacts on distantly related plants. Importantly, these same patterns generally held for native plants, as distantly related native plants were more abundant and more susceptible to herbivores than closely related species, ultimately resulting in herbivores suppressing community‐level phylogenetic diversity.Main conclusions Distantly related plants were more locally successful despite experiencing stronger control by generalist herbivores, a finding that was robust across native and exotic species. To our knowledge, this is the first evidence that phylogenetic matching influences the local success of both native and exotic species and that herbivores can influence community phylodiversity. Phylogenetic relatedness explained a relatively small portion of the variance in the data even after taking herbivory into account, however, suggesting that phylogenetic matching works in combination with other factors to influence community assembly.
Genetic polymorphisms and microRNAs: new direction in molecular epidemiology of solid cancer
Authors: Slaby Ondrej , Bienertova‐Vasku Julie , Svoboda Marek , Vyzula Rostislav 
Published: June 2011

Abstract
Introduction
Classification of miRNA‐related SNPs
MiRNA‐related SNPs and solid cancer
Conclusions and future directions
MicroRNAs (miRNAs) are small non‐coding RNAs, which regulate gene expression. Single nucleotide polymorphisms (SNPs) may occur in miRNA biogenesis pathway genes, primary miRNA, pre‐miRNA or a mature miRNA sequence. Such polymorphisms may be functional with respect to biogenesis and actions of mature miRNA. Specific SNPs were identified in predicted miRNA target sites within 3′ untranslated regions of mRNAs. These SNPs have a potential to affect the efficiency of miRNA binding to the target sites or can create or disrupt binding sites. Resulting gene dysregulation may involve changes in phenotype and may eventually prove critical for the susceptibility to cancer and its onset as well as for estimates of prognosis and therapy response. In this review, we provide a comprehensive list of potentially functional miRNA‐related SNPs and summarize their importance as candidate cancer biomarkers.
KATP channel agonists preserve connexin43 protein in infarcted rats by a protein kinase C‐dependent pathway
Authors: Lee Tsung‐Ming , Lin Chih‐Chan , Lien Hsiao‐Yin , Chen Chien‐Chang 
Published: June 2011

AbstractDownward remodelling of gap junctional proteins between myocytes may trigger ventricular arrhythmia after myocardial infarction. We have demonstrated that ATP‐sensitive potassium (KATP) channel agonists attenuated post‐infarction arrhythmias. However, the involved mechanisms remain unclear. The purpose of this study was to determine whether KATP channel agonists can attenuate arrhythmias through preserving protein kinase C (PKC)‐ε–dependent connexin43 level after myocardial infarction. Male Wistar rats after ligating coronary artery were randomized to either vehicle, nicorandil, pinacidil, glibenclamide or a combination of nicorandil and glibenclamide or pinacidil and glibenclamide for 4 weeks. To elucidate the role of PKCε in the modulation of connexin43 level, carbachol and myristoylated PKCε V1–2 peptide were also assessed. Myocardial connexin43 level was significantly decreased in vehicle‐treated infarcted rats compared with sham. Attenuated connexin43 level was blunted after administering KATP channel agonists, assessed by immunofluorescent analysis, Western blotting, and real‐time quantitative reverse transcription‐PCR of connexin43. Arrhythmic scores during programmed stimulation in the KATP channel agonists‐treated rats were significantly lower than those treated with vehicle. The beneficial effects of KATP channel agonists were blocked by either glibenclamide or 5‐hydroxydecanoate. Addition of the PKC activator, phorbol 12‐myristate 13‐acetate and the specific PKCε agonist, carbachol, blocked the effects of nicorandil on connexin43 phosphorylation and dye permeability. The specific PKCε antagonist, myristoylated PKCε V1–2 peptide, did not have additional beneficial effects on connexin43 phosphorylation compared with rats treated with nicorandil alone. Chronic use of KATP channel agonists after infarction, resulting in enhanced connexin43 level through a PKCε‐dependent pathway, may attenuate the arrhythmogenic response to programmed electrical stimulation.
The role of Campylobacter jejuni cytolethal distending toxin in gastroenteritis: toxin detection, antibody production, and clinical outcome
Authors: MORTENSEN NINELL P. , SCHIELLERUP PETER , BOISEN NADIA , KLEIN BJARKE M. , LOCHT HENNING , ABUOUN MANAL , NEWELL DIANE , KROGFELT KAREN A. 
Published: June 2011

Mortensen NP, Schiellerup P, Boisen N, Klein BM, Locht H, AbuOun M, Newell D, Krogfelt KA. The role of Campylobacter jejuni cytolethal distending toxin in gastroenteritis: toxin detection, antibody production and clinical outcome. APMIS 2011.The role of Campylobacter jejuni cytolethal distending toxin (CDT) on clinical outcome after gastroenteritis was investigated. Clinical data, blood serum samples, and Campylobacter spp. isolated, from each of 30 patients were collected over a period of 6 months. The CDT encoding genes, cdtABC, characterized by PCR, revealed that all but one of the C. jejuni strains had the wild‐type sequence. Sequencing of cdtABC from this strain showed two major deletions. From all of the strains, CDT titers were determined, and toxin neutralizing antibodies were documented using an in vitro assay. Three of the thirty clinical isolates, including the one with the mutant cdtABC coding genes, did not have a detectable CDT activity. Analyzing the relationship between CDT titer, serum neutralization of CDT, and the clinical outcome showed that campylobacteriosis caused by CDT‐negative strains was clinically indistinguishable from that of patients infected with an isolate that produced high levels of CDT. These results suggest that CDT does not solely determine severity of infection and clinical outcome.