bluuebunny/crossref_metadata_2025_split huggingface dataset:
Breast cancer in women by HIV status: A report from the South African National Cancer Registry
Authors: Davidović Maša , Dhokotera Tafadzwa , dos-Santos-Silva Isabel , Bohlius Julia , Sengayi-Muchengeti Mazvita 
Published: June 2024

Background
Breast cancer (BC) is the leading cause of cancer-related morbidity and mortality in women living in South Africa, a country with a high HIV burden. However, characteristics of the double burden of HIV and BC in South Africa have not been properly investigated. We described characteristics of BC cases by HIV status in South Africa.

Methods
In this nationwide South African study, we obtained BC records for women aged ≥15 years diagnosed in the public health sector between January 2004 and December 2014. We included records from the National Cancer Registry that had been linked to HIV-related laboratory records from the National Health Laboratory Service. We assessed the odds of being HIV positive versus HIV negative in relation to patient-, cancer-, and municipality-related characteristics.

Results
From 2004–2014, 40 520 BC cases were diagnosed in women aged ≥15 years. Of these, 73.5% had unknown HIV status, 18.7% were HIV negative, and 7.7% were HIV positive. The median age at BC diagnosis was 43 years (interquartile range [IQR]: 37–52) in HIV positive and 57 years (IQR: 46–68) in HIV negative women, respectively. The odds of being HIV positive was higher for women who were aged 30–34 years compared to women aged 35–39 years at cancer diagnosis (odds ratio [OR] 1.38, 95% confidence interval [CI] 1.10–1.71), Black versus non-Black (OR 6.41, 95% CI 5.68–7.23), diagnosed with cancer in rural versus urban areas (OR 1.59, 95% CI 1.40–1.82) and diagnosed in municipalities with low and middle (OR 3.46, 95% CI 2.48–4.82) versus high socioeconomic position (OR 2.69, 95% CI 2.11–3.42).

Conclusion
HIV status was unknown for the majority of BC patients. Among those with known HIV status, being HIV positive was associated with a younger age at cancer diagnosis, being Black and receiving care in municipalities of poor socioeconomic position. Future studies should examine opportunities to integrate HIV and BC control programs.
Forsythoside B alleviates cerebral ischemia-reperfusion injury via inhibiting NLRP3 inflammasome mediated by SIRT1 activation
Authors: Li Qiaoyu , Zhang Chongyang , Sun Xiao , Wang Mengchen , Zhang Zhixiu , Chen Rongchang , Sun Xiaobo 
Published: June 2024

Background
The inflammatory response is a key factor in the pathogenesis of cerebral ischemia/reperfusion injury (CIRI), and anti-inflammatory interventions may offer a promising therapeutic strategy. Forsythoside B (FB) is a phenylethanoid glycoside isolated from Forsythiae fructus, which has been reported to have anti-inflammatory effects. However, the mechanism of the neuroprotective effect of FB on CIRI remains unclear.

Methods
Adult male Sprague-Dawley rats were subjected to transient middle cerebral artery occlusion/reperfusion (MCAO/R). FB was administered intraperitoneally for 3 days prior to MCAO/R. Cerebral infarct volume and neurological deficit score were used as indices to evaluate MCAO/R injury. The serum levels of inflammatory factors and antioxidant enzymes were measured. The activation of silent information regulator 2 homolog 1 (Sirt1) and the inhibition of the nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 (NLRP3) pathway were assessed through western blot and immunohistochemistry analysis. Furthermore, the rats were treated with Sirt1 shRNA 3 days before MCAO/R by stereotactical injection into the ipsilateral hemispheric region to assess the impact of Sirt1 knockdown on the protection of FB during MCAO/R.

Results
FB reduced cerebral infarct volume and neurological deficit score in MCAO/R rats. FB reduced pathological changes and cell apoptosis in the hippocampal CA1 region and cortex on the ischemic side of rats. FB inhibited the serum levels of inflammatory factors and increased the activities of antioxidant enzymes. Further study showed that FB inhibited the activation of the NLRP3 pathway and induced Sirt1 activation.

Conclusion
FB demonstrated neuroprotective and anti-inflammatory effects by inhibiting the NLRP3 pathway through Sirt1 activation in CIRI.
Insulin reduces endoplasmic reticulum stress‐induced apoptosis by decreasing mitochondrial hyperpolarization and caspase‐12 in INS‐1 pancreatic β‐cells
Authors: Murata Nanako , Nishimura Kana , Harada Naoki , Kitakaze Tomoya , Yoshihara Eiji , Inui Hiroshi , Yamaji Ryoichi 
Published: June 2024

AbstractPancreatic β‐cell mass is a critical determinant of insulin secretion. Severe endoplasmic reticulum (ER) stress causes β‐cell apoptosis; however, the mechanisms of progression and suppression are not yet fully understood. Here, we report that the autocrine/paracrine function of insulin reduces ER stress‐induced β‐cell apoptosis. Insulin reduced the ER‐stress inducer tunicamycin‐ and thapsigargin‐induced cell viability loss due to apoptosis in INS‐1 β‐cells. Moreover, the effect of insulin was greater than that of insulin‐like growth factor‐1 at physiologically relevant concentrations. Insulin did not attenuate the ER stress‐induced increase in unfolded protein response genes. ER stress did not induce cytochrome c release from mitochondria. Mitochondrial hyperpolarization was induced by ER stress and prevented by insulin. The protonophore/mitochondrial oxidative phosphorylation uncoupler, but not the antioxidants N‐acetylcysteine and α‐tocopherol, exhibited potential cytoprotection during ER stress. Both procaspase‐12 and cleaved caspase‐12 levels increased under ER stress. The caspase‐12 inhibitor Z‐ATAD‐FMK decreased ER stress‐induced apoptosis. Caspase‐12 overexpression reduced cell viability, which was diminished in the presence of insulin. Insulin decreased caspase‐12 levels at the post‐translational stages. These results demonstrate that insulin protects against ER stress‐induced β‐cell apoptosis in this cell line. Furthermore, mitochondrial hyperpolarization and increased caspase‐12 levels are involved in ER stress‐induced and insulin‐suppressed β‐cell apoptosis.
Design of novel UPFC based damping controller for solar PV integrated power system using arithmetic optimization algorithm
Authors: Bohidar Sankalpa , Mallick Ranjan Kumar , Nayak Pravati , Mishra Sairam , Nahak Narayan , Panda Gayadhar , Gouda Pramod Kumar 
Published: June 2024

Abstract
Integrating renewable energy sources like solar power into traditional power systems poses challenges. One such challenge is the effect of renewable power plants, which use power electronics, on the grid’s stability. Specifically, these plants can impact small-signal stability by either damping or exacerbating low-frequency oscillations. This paper introduces a novel Unified Power Flow Controller (UPFC) based damping controller specifically designed for Solar Photovoltaic (PV) integrated power systems. It employs an Arithmetic Optimization Algorithm (AOA) to optimize the UPFC damping controller parameters and mitigate low-frequency oscillations in the power system. The objective function minimizes the Integral Time Absolute Error (ITAE) of speed deviations under varying loading conditions. The proposed technique is utilized simultaneously to control the modulation index of series and phase angle of shunt converters of UPFC. The MATLAB/simulation results obtained effectively from the proposed technique which is actualized and identify both detrimental and beneficial impacts of increased PV penetration for small signal stability performance. The study reveals both the small-signal stability of the system and its response to large disturbances that alter the active power balance and frequency stability. The results of the analysis demonstrated with single and multimachine environment by comparing with the other optimizations like PSO, DE, DE-PSO and GWO, the proposed one is effective for damping out the oscillations. The effectiveness of the proposed damping controller is further confirmed through real-time validation using the OPAL-RT setup.
Where is the Seeker Who Searches for Another? Decolonial Approaches to Digital Public History
Authors: Maina Chao Tayiana 
Published: June 2024

Abstract
This article delves into the role of public history within the context of suppressed and erased colonial pasts, underscoring the importance of individuals in actively shaping, uncovering, documenting and disseminating history. The period from the late 1940s–1960s marked a pivotal transition for the British Empire, as numerous colonies gained independence. This shift in sovereignty from colonial rule to sovereign nations unveiled deep apprehensions regarding the potential use of Britain’s historical actions and documents by newly independent governments. Operation Legacy was a clandestine initiative by British colonial authorities to destroy or hide records that could tarnish the British government’s image or compromise secret intelligence. The ethical ramifications of this operation, and its impact on the construction of memory and knowledge, remain a contentious issue for many in former colonies who are still striving to piece together their colonial history and seek justice for past wrongs. By highlighting the experience, methodologies and challenges of the Museum of British Colonialism collective, the article explores what a framework for decolonial public history may look like in a digital age. Decolonial public history requires negotiations that are continuously shaped by interrogating multiple sources, employing multiple mediums, engaging diverse audiences, and constantly reflecting and refining one’s own process and methodology. Inspired by Ngugi wa Thiong’o’s influential work Devil on the Cross, which portrays resistance to colonialism as a communal and interconnected endeavor, the article reflects on the character Wariinga’s query: “Where is the seeker who searches for another?” It concludes with thoughts on how digital public history can achieve decolonial significance and effectiveness, not merely through technological means, but by centering human connections and extensively building communities of practice across multiple frontiers.
A fiber-wireless integration approach in WDM-PON architecture, boosted with polarization multiplexing and optical frequency comb source
Authors: Lamba Ankita , Sehgal Jyoti , Kumar Manoj , Akanksha Eisha 
Published: June 2024

Abstract
The paper discusses an optical frequency comb source (OMCG)-enabled hybrid single mode fiber (SMF) and free space optical (FSO) communication system (fiber-wireless) delivering a total capacity of 96 Gbps by incorporating polarization division multiplexing (PDM) in passive optical network (PON) architecture. For the accomplishment of PDM, three diverse states of polarization (SOPs) are explored such as 00, 450, and 900. Performance investigation of proposed system is conducted for assessing Q factor and BER by exploring the different modulation formats in proposed system such as modified duo-binary return to zero (MDRZ), return to zero (RZ), compressed spectrum RZ (CSRZ), and non-RZ (NRZ). Results revealed that presented design can cover 30 km SMF + 3.4 km FSO range by incorporating MDRZ due to its spectral efficient and dispersion tolerant properties.
Verbal extensions in Sheng: an examination of variation in form and function
Authors: Kariuki Annah , Gibson Hannah , Jelpke Tom , Ochieng Merceline , Poeta Teresa 
Published: June 2024

Abstract
This paper investigates verbal extensions in Sheng, a youth language originating in Nairobi, Kenya. Sheng has received scholarly attention since the 1980s, primarily with a focus on its sociolinguistic traits. Our study aims to advance the linguistic description of Sheng and its morphosyntax by investigating verbal extensions in Sheng. Specifically, we look at the causative, applicative, reciprocal, and passive suffixes, as they are applied to coined and metathesized verbs and verbs which have their origins in Swahili, English, or Gikuyu. We present examples from speakers in Kibera and Umoja neighbourhoods of Nairobi. We find that, while many of the extensions can be applied to elicited verbs, such examples were often considered odd by speakers. In some cases, our consultants suggested alternative strategies, typically employing the use of periphrastic constructions or different verb forms. The use of verbal extensions sometimes resulted in changes in interpretation, requiring us to re-consider the function of these extensions in Sheng more broadly.
Joint application of the Monte Carlo method and computational probabilistic analysis in problems of numerical modeling with data uncertainties
Authors: Dobronets Boris , Popova Olga 
Published: June 2024

Abstract
In this paper, we suggest joint application of computational probabilistic analysis and the Monte Carlo method for numerical stochastic modeling problems.
We use all the capabilities of computational probabilistic analysis while maintaining all the advantages of the Monte Carlo method.
Our approach allows us to efficiently implement a computational hybrid scheme.
In this way, we reduce the computation time and present the results in the form of distributions.
The crucial new points of our method are arithmetic operations on probability density functions and procedures for constructing on the probabilistic extensions.
Relying on specific numerical examples of solving systems of linear algebraic equations with random coefficients, we present the advantages of our approach.
Frankincense: A neuronutrient to approach Parkinson’s disease treatment
Authors: Calabrese Vittorio , Osakabe Naomi , Khan Foziya , Wenzel Uwe , Modafferi Sergio , Nicolosi Lidia , Fritsch Tilman , Jacob Ursula M. , Abdelhameed Ali S. , Rashan Luay 
Published: June 2024

Abstract
Parkinson’s disease (PD), characterized by tremor, slowness of movement, stiffness, and poor balance, is due to a significant loss of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic nerve terminals in the striatum with deficit of dopamine. To date the mechanisms sustaining PD pathogenesis are under investigation; however, a solid body of experimental evidence involves neuroinflammation, mitochondrial dysfunction, oxidative stress, and apoptotic cell death as the crucial factors operating in the pathogenesis of PD. Nutrition is known to modulate neuroinflammatory processes implicated in the pathogenesis and progression of this neurodegenerative disorder. Consistent with this notion, the Burseraceae family, which includes the genera Boswellia and Commiphora, are attracting emerging interest in the treatment of a wide range of pathological conditions, including neuroinflammation and cognitive decline. Bioactive components present in these species have been shown to improve cognitive function and to protect neurons from degeneration in in vitro, animal, as well as clinical research. These effects are mediated through the anti-inflammatory, antiamyloidogenic, anti-apoptotic, and antioxidative properties of bioactive components. Although many studies have exploited possible therapeutic approaches, data from human studies are lacking and their neuroprotective potential makes them a promising option for preventing and treating major neurodegenerative disorders.
Preservation as a Shared Responsibility: Collaboration for the Sustainable Preservation of Ambon Manuscripts
Authors: Wibowo Sarwo Ferdi , Alfida  , Fuad Khairul , Ma’rifat Devi Fauziyah , Zuhrah Fatimah , Warnis  
Published: June 2024

Abstract
The study supplements manuscript digitization, which often overlooks owners’ role in manuscript literacy, highlighting their integral connection to preservation efforts. This is particularly relevant concerning Ambon manuscripts in the former Hitu kingdom. The study’s primary objective is to discern optimal practices for sustainable preservation, emphasizing the community owners not as passive entities but as individuals possessing significant knowledge and skills, competencies which can be effectively employed to safeguard and uphold manuscripts. The data collection process encompassed comprehensive literature reviews on digital manuscript collections, interviews with owners, focus group discussions (FGD) involving the younger generation of heirs, FGD with Ambon manuscript researchers at IAIN Ambon, and observations on manuscripts and cultural practices within the community. The findings reveal notable aspects such as: 1) degradation occurs in Ambon manuscripts, both in their physical state and the transmission of knowledge post-digitization, which underscores a deficiency in knowledge transfer between manuscript users and owners, representing an ethical responsibility; 2) within Ambon society, old houses function as literacy centers for the community. Given the substantial quantity of manuscripts, these houses should be recognized as scriptoria and serve as foundational points for manuscript-based literacy development; and 3) traditional practices within owner communities indicate that manuscript knowledge/literacy extends beyond basic reading and writing skills. It encompasses a holistic and comprehensive understanding of knowledge, including its relevance to daily life, categorization, origins, literacy, preservation skills (particularly caring and copying), and utilization (for legitimacy, anticipation/conflict resolution, and even economic purposes).
Research on performance seeking control of turbofan engine in minimum hot spot temperature mode
Authors: Liu Yabing , Zhang Hongwei , Ma Bei , Li Liangliang , Hu Chenxu , Zheng Qiangang , Zhang Haibo 
Published: June 2024

Abstract
The uneven temperature distribution at the combustion chamber outlet seriously affects the working life of the engine. In order to reduce the heat spot temperature at the combustion chamber outlet, a performance optimization control method of the engine minimum heat spot temperature pattern is proposed. Firstly, based on CFD method, the temperature distribution characteristics of combustion chamber outlet under different working conditions were obtained, and a component-level model of turbofan engine was established to characterize the heat spot temperature at combustion chamber outlet. Secondly, the high precision and high real-time engine on-board model is established by deep neural network. Compared with the component-level model, the average relative error of each performance parameter is less than 0.3 %, and the real-time performance is improved by 12 times. Finally, based on the feasible sequential quadratic programming algorithm, the performance optimization control of the minimum hot spot temperature model in the typical flight envelope is simulated and verified. The simulation results show that under the condition of ensuring the safe and stable operation of the engine and constant thrust, the heat spot temperature at the combustion chamber outlet decreases by 21 K maximum. Compared with the conventional minimum turbine front temperature optimization mode, the minimum heat spot temperature mode significantly reduces the heat spot temperature at the combustion chamber outlet.
Wissensmanagement in KMU
Authors: Kick Elena , Schiedermair Ina , Baumgartner Marco , Kopp Tobias , Kinkel Steffen 
Published: June 2024

Abstract
The absence of individual key personnel can have a significant impact on companies’ business operations. It is therefore important for companies to analyse business-critical processes and secure them through knowledge management activities. In this article, we present the characteristics of business-critical processes and a tool for identifying and prioritising them, thereby making an important contribution to preventive, systematic knowledge management.
Nachhaltige Steigerung der Produkt- und Prozessqualität
Authors: Abramowski Johann-Philip , Quito Fernando , Grunert Dennis , Schmitt Robert H. 
Published: June 2024

Abstract
The quality in the product creation process is of crucial importance for manufacturing companies in terms of customer satisfaction and thus economic success. However, a growing variety and increasing product requirements pose challenges to the achievable product quality and the necessary processes. As a result, quality defects often occur in the development, manufacturing, and the application of a product. To be able to sustainably learn from the errors that have occurred and to initiate a suitable process of continuous product improvement as a company, the introduction of QRQC (Quick Response Quality Control) may be necessary. To illustrate the implementation of such a methodological approach, this article exemplarily presents the introduction and functionality of a problem-solving system at Liebherr Hydraulikbagger GmbH.
DreMoWabe – Dresdner Modell der Wandlungsbefähigung
Authors: Jäpel Nicole , Bielitz Pia , Stoll Elena , Reichelt Dirk 
Published: June 2024

Abstract
The Dresden Model of Adaptability (DreMoWabe for short) presents key aspects of the human-technology-organization approach and the transformation enablers commonly found in the Literature. Together with the design levels of networked value creation, company level, factory planning, human-machine interaction and machine level identified as essential, this results in a three-dimensional structure. It thus serves as a reference and regulatory framework to enable production companies to describe and evaluate their own adaptability in a model and to react more quickly to changes in the production environment on the basis of criteria and corresponding recommendations.
From Intel & Qualcomm to the new Art. 102 TFEU-Guidelines – Streamlining the Form- & Effects Based Approach
Authors: Pauer Nada Ina 
Published: June 2024

Abstract
Rapid digital innovation has promoted a broad range of welfare aspects and created a myriad of new business models. While these benefits are uncontentious, the special characteristics of digital markets, such as strong network effects, have led to a substantial concentration of power among a few corporate actors. The increasing complexity of these market dynamics has rendered antitrust enforcement more challenging, particularly with regard to assessing the abuse of market dominance (Art. 102 TFEU). Particularly the European Commission has been confronted with criticism relating to its previously propagated “more economic approach”, which has led to a lack of timely and effective antitrust enforcement. While there is a consensus that a new approach to ascertaining the abuse of dominance is pertinent – which the Commission endorses – the underlying assessment parameters are still contentious. This article argues for a standard of dominance to notably reflect the digital transformation and include a comprehensive framework. While the predominant intervention aim must be based on sufficient innovation, a notion of economic fairness and sustainability considerations gain momentum in antitrust enforcement.