bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elasto-plastic residual stress analysis of selective laser sintered porous materials based on 3D-multilayer thermo-structural phase-field simulations
Authors: Yang Yangyiwei , Bharech Somnath , Finger Nick , Zhou Xiandong , Schröder Jörg , Xu Bai-Xiang 
Published: May 2024

AbstractResidual stress and plastic strain in additive manufactured materials can exhibit significant microscopic variation at the powder scale, profoundly influencing the overall properties of printed components. This variation depends on processing parameters and stems from multiple factors, including differences in powder bed morphology, non-uniform thermo-structural profiles, and inter-layer fusion. In this research, we propose a powder-resolved multilayer multiphysics simulation scheme tailored for porous materials through the process of selective laser sintering. This approach seamlessly integrates finite element method (FEM) based non-isothermal phase-field simulation with thermo-elasto-plastic simulation, incorporating temperature- and phase-dependent material properties. The outcome of this investigation includes a detailed depiction of the mesoscopic evolution of stress and plastic strain within a transient thermo-structure, evaluated across a spectrum of beam power and scan speed parameters. Simulation results further reveal the underlying mechanisms. For instance, stress concentration primarily occurs at the necking region of partially melted particles and the junctions between different layers, resulting in the accumulation of plastic strain and residual stress, ultimately leading to structural distortion in the materials. Based on the simulation data, phenomenological relation regarding porosity/densification control by the beam energy input was examined along with the comparison to experimental results. Regression models were also proposed to describe the dependency of the residual stress and the plastic strain on the beam energy input.
Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki disease
Authors: Shrestha Sadeep , Wiener Howard W. , Chowdhury Sabrina , Kajimoto Hidemi , Srinivasasainagendra Vinodh , Mamaeva Olga A. , Brahmbhatt Ujval N. , Ledee Dolena , Lau Yung R. , Padilla Luz A. , Chen Jake Y. , Dahdah Nagib , Tiwari Hemant K. , Portman Michael A. 
Published: May 2024

AbstractKawasaki disease (KD) is a multisystem inflammatory illness of infants and young children that can result in acute vasculitis. The mechanism of coronary artery aneurysms (CAA) in KD despite intravenous gamma globulin (IVIG) treatment is not known. We performed a Whole Genome Sequencing (WGS) association analysis in a racially diverse cohort of KD patients treated with IVIG, both using AHA guidelines. We defined coronary aneurysm (CAA) (N = 234) as coronary z ≥ 2.5 and large coronary aneurysm (CAA/L) (N = 92) as z ≥ 5.0. We conducted logistic regression models to examine the association of genetic variants with CAA/L during acute KD and with persistence >6 weeks using an additive model between cases and 238 controls with no CAA. We adjusted for age, gender and three principal components of genetic ancestry. The top significant variants associated with CAA/L were in the intergenic regions (rs62154092 p < 6.32E–08 most significant). Variants in SMAT4, LOC100127, PTPRD, TCAF2 and KLRC2 were the most significant non-intergenic SNPs. Functional mapping and annotation (FUMA) analysis identified 12 genomic risk loci with eQTL or chromatin interactions mapped to 48 genes. Of these NDUFA5 has been implicated in KD CAA and MICU and ZMAT4 has potential functional implications. Genetic risk score using these 12 genomic risk loci yielded an area under the receiver operating characteristic curve (AUC) of 0.86. This pharmacogenomics study provides insights into the pathogenesis of CAA/L in IVIG-treated KD and shows that genomics can help define the cause of CAA/L to guide management and improve risk stratification of KD patients.
Identification of drug responsive enhancers by predicting chromatin accessibility change from perturbed gene expression profiles
Authors: Wang Yongcui , Wang Yong 
Published: May 2024

AbstractIndividual may response to drug treatment differently due to their genetic variants located in enhancers. These variants can alter transcription factor’s (TF) binding strength, affect enhancer’s chromatin activity or interaction, and eventually change expression level of downstream gene. Here, we propose a computational framework, PERD, to Predict the Enhancers Responsive to Drug. A machine learning model was trained to predict the genome-wide chromatin accessibility from transcriptome data using the paired expression and chromatin accessibility data collected from ENCODE and ROADMAP. Then the model was applied to the perturbed gene expression data from Connectivity Map (CMAP) and Cancer Drug-induced gene expression Signature DataBase (CDS-DB) and identify drug responsive enhancers with significantly altered chromatin accessibility. Furthermore, the drug responsive enhancers were related to the pharmacogenomics genome-wide association studies (PGx GWAS). Stepping on the traditional drug-associated gene signatures, PERD holds the promise to enhance the causality of drug perturbation by providing candidate regulatory element of those drug associated genes.
Primary cilia suppress the fibrotic activity of atrial fibroblasts from patients with atrial fibrillation in vitro
Authors: Kawasaki Makiri , Al-Shama Rushd F. M. , Nariswari Fransisca A. , Fabrizi Benedetta , van den Berg Nicoline W. E. , Wesselink Robin , Neefs Jolien , Meulendijks Eva R. , Baalman Sarah W. E. , Driessen Antoine H. G. , de Groot Joris R. 
Published: May 2024

AbstractAtrial fibrosis serves as an arrhythmogenic substrate in atrial fibrillation (AF) and contributes to AF persistence. Treating atrial fibrosis is challenging because atrial fibroblast activity is multifactorial. We hypothesized that the primary cilium regulates the profibrotic response of AF atrial fibroblasts, and explored therapeutic potentials of targeting primary cilia to treat fibrosis in AF. We included 25 patients without AF (non-AF) and 26 persistent AF patients (AF). Immunohistochemistry using a subset of the patients (non-AF: n = 10, AF: n = 10) showed less ciliated fibroblasts in AF versus non-AF. Acetylated α-tubulin protein levels were decreased in AF, while the gene expressions of AURKA and NEDD9 were highly increased in AF patients’ left atrium. Loss of primary cilia in human atrial fibroblasts through IFT88 knockdown enhanced expression of ECM genes, including FN1 and COL1A1. Remarkably, restoration or elongation of primary cilia by an AURKA selective inhibitor or lithium chloride, respectively, prevented the increased expression of ECM genes induced by different profibrotic cytokines in atrial fibroblasts of AF patients. Our data reveal a novel mechanism underlying fibrotic substrate formation via primary cilia loss in AF atrial fibroblasts and suggest a therapeutic potential for abrogating atrial fibrosis by restoring primary cilia.
Blasting profile evaluation of sand-mud interbedded surrounding rock during the large-span tunnel construction
Authors: Ma LongHao , Lin Fei , Du Yanqiang , Ren Song , Long NengZeng , Zhang Ping 
Published: May 2024

AbstractThe sand-mud interbedded surrounding rock contains discontinuities, such as horizontal bedding, joints, weak planes and weak interlayers. Drilling and blasting construction in this kind of surrounding rock is very likely to cause very serious over-/under-excavation phenomenon and excessive damage to surrounding rock, and the contour flatness after smooth blasting of the tunnel is also difficult to be guaranteed, which increases subsequent construction procedures and reduces production efficiency. In order to effectively evaluate the smooth blasting effect of the sand-mud interbedded surrounding rock tunnel, taking a tunnel project in southwest China as the research background, the blasting numerical simulation of the sand-mud interbedded surrounding rock tunnel was carried out using the dynamic analysis program, and the corresponding blasting optimization scheme was obtained. Subsequently, based on fuzzy mathematical theory, the evaluation system of blasting effect of sand-mud interbedded tunnel was established by combining the evaluation criteria of tunnel smooth blasting quality. Immediately afterwards, the weights of each influencing factor index were determined, and the blasting shaping effect of the original blasting scheme and the optimized blasting scheme was evaluated. Finally, the results have shown that the optimized tunnel blasting profile effect was better than the original blasting scheme. The corresponding research results have certain guiding significance for similar tunnel blasting effect evaluation and blasting parameter design.
Identification of small molecular inhibitors of SIRT3 by computational and biochemical approaches a potential target of breast cancer
Authors: Ullah Atta , Rehman Najeeb Ur , Islam Waseem Ul , Khan Faizullah , Waqas Muhammad , Halim Sobia Ahsan , Jan Afnan , Muhsinah Abdullatif Bin , Khan Ajmal , Al-Harrasi Ahmed 
Published: May 2024

AbstractSirtuin 3 (SIRT3) belongs to the Sirtuin protein family, which consists of NAD+-dependent lysine deacylase, involved in the regulation of various cellular activities. Dysregulation of SIRT3 activity has been linked to several types of cancer, including breast cancer. Because of its ability to stimulate adaptive metabolic pathways, it can aid in the survival and proliferation of breast cancer cells. Finding new chemical compounds targeted towards SIRT3 was the primary goal of the current investigation. Virtual screening of ~ 800 compounds using molecular docking techniques yielded 8 active hits with favorable binding affinities and poses. Docking studies verified that the final eight compounds formed stable contacts with the catalytic domain of SIRT3. Those compounds have good pharmacokinetic/dynamic properties and gastrointestinal absorption. Based on excellent pharmacokinetic and pharmacodynamic properties, two compounds (MI-44 and MI-217) were subjected to MD simulation. Upon drug interaction, molecular dynamics simulations demonstrate mild alterations in the structure of proteins and stability. Binding free energy calculations revealed that compounds MI-44 (− 45.61 ± 0.064 kcal/mol) and MI-217 (− 41.65 ± 0.089 kcal/mol) showed the maximum energy, suggesting an intense preference for the SIRT3 catalytic site for attachment. The in-vitro MTT assay on breast cancer cell line (MDA-MB-231) and an apoptotic assay for these potential compounds (MI-44/MI-217) was also performed, with flow cytometry to determine the compound’s ability to cause apoptosis in breast cancer cells. The percentage of apoptotic cells (including early and late apoptotic cells) increased from 1.94% in control to 79.37% for MI-44 and 85.37% for MI-217 at 15 μM. Apoptotic cell death was effectively induced by these two compounds in a flow cytometry assay indicating them as a good inhibitor of human SIRT3. Based on our findings, MI-44 and MI-217 merit additional investigation as possible breast cancer therapeutics.
2D Magnetic heterostructures: spintronics and quantum future
Authors: Zhang Bingyu , Lu Pengcheng , Tabrizian Roozbeh , Feng Philip X.-L. , Wu Yingying 
Published: May 2024

AbstractThe discovery of two-dimensional (2D) magnetism within atomically thin structures obtained from layered magnetic crystals has opened up a new realm for exploring magnetic heterostructures. This emerging field provides a foundational platform for investigating unique physical properties and exquisite phenomena at the nanometer and molecular/atomic scales. By engineering 2D interfaces using physical methods and selecting interlayer interactions, we can unlock the potential for extraordinary exchange dynamics, which extends to high-performance and high-density magnetic memory applications, as well as future advancements in neuromorphic and quantum computing. This review delves into recent advances in magnetic 2D materials, elucidates the mechanisms behind 2D interfaces, and highlights the development of 2D devices for spintronics and quantum information processing. Particular focus is placed on 2D magnetic heterostructures with topological properties, promising a resilient and low-error information system. Finally, we discuss the trends of 2D heterostructures for future electronics, considering the challenges and opportunities from physics, material synthesis, and technological perspectives.
Breast Cancer Local Recurrence Risk in Implant-Based Breast Reconstruction with Macrotexturized and Microtexturized Prosthesis: A Multicentric Retrospective Cohort Study
Authors: Vinci Valeriano , Klinger Francesco , Di Giuli Riccardo , Lisa Andrea Vittorio Emanuele , Catania Barbara , Vaccari Stefano , Caimi Edoardo , Pitassi Emanuele , Filippo Jacopo Di , Gentile Damiano , Tinterri Corrado , Janszen Gerardus Johannes , Klinger Marco 
Published: May 2024

Abstract
Background Nowadays, implant-based breast reconstruction is a common technique after mastectomy. The widespread use of implant employment is prompting significant concerns regarding the oncological safety of prostheses and the potential impact of surface texture on the recurrence of local breast cancer. This article examines the oncological outcomes associated with postmastectomy breast reconstructions using micro- and macrotexturized implants, focusing on the incidence and relative risk (RR).
Materials and Methods A retrospective cohort study was conducted on patients admitted to Multimedica group (IRCCS, San Giovanni Hospital, Milan) and ICH groups (Humanitas Clinical Institute, Milan) between January 2003 and September 2020. Minimum follow-up considered was of 1 year.Patients submitted to either complete or nipple-spearing mastectomy, who underwent breast reconstruction with macrotexturized or microtexturized prosthesis, were included in group A and B, respectively.
Results A total of 646 patients met the basic inclusion and exclusion criteria. Group A included 410 (63.5%) patients and group B included 236 (36.5%). Cancer recurrence absolute risk in group A was 5.6 ± 2.2% and in group B was of 2.1 ± 1.8%. RR for breast cancer recurrence in group A compared to group B was of 2.65; confidence interval 95% (1.02; 6.87). Statistical analysis identified a higher local recurrence risk in patients reconstructed with macrotexturized prosthesis (p-value 0.036).
Conclusion This study detected a higher risk for local breast cancer recurrence associated to macrotexturized breast implants employment. Further investigations are required to verify these outcomes.
Japan’s construction of defensive fortifications and its implications for East Asian relations during the Tang dynasty
Authors: Li Zhuang , Liu Kehua 
Published: May 2024

AbstractJapan’s construction of fortifications throughout its history has been a subject of scholarly interest. Japan has been building fortifications for generations, from Muzuki and stone fortifications at home to Japanese fortifications on the Korean peninsula. While it is commonly believed that the need for castle building in Japan emerged after the Battle of Baekgang, this paper suggests that Japan’s sense of external tensions predates this event. Specifically, this paper examines the construction of defensive fortifications at Itojo and Onojo during the Tang Dynasty and its implications for Japan’s relations with East Asia. Through an analysis of historical records and archeological evidence, this paper argues that the construction of Onojo may have begun as early as around AD 650, challenging the prevailing view in academic circles, which holds that Onojo was built after the defeat of Baekgang. By examining the development of Japan’s relations with East Asia during this period, this paper sheds light on the geopolitical significance of Japan’s construction of defensive fortifications.
High-temperature insulating ferromagnetic state in charge-disproportionated and spin-state-disproportionated strained SrCoO2.5 thin film
Authors: Chowdhury Sourav , Jana Anupam , Rawat Ritu , Yadav Priyanka , Islam Rajibul , Xue Fei , Mandal A. K. , Sarkar Sumit , Mishra Rajan , Venkatesh R. , Phase D. M. , Choudhary R. J. 
Published: May 2024

Ferromagnetic insulators (FMIs) have widespread applications in microwave devices, magnetic tunneling junctions, and dissipationless electronic and quantum-spintronic devices. However, the sparsity of the available high-temperature FMIs has led to the quest for a robust and controllable insulating ferromagnetic state. Here, we present compelling evidence of modulation of the magnetic ground state in a SrCoO2.5 (SCO) thin film via strain engineering. The SCO system is an antiferromagnetic insulator with a Neel temperature, TN, of ∼550 K. Applying in-plane compressive strain, the SCO thin film reveals an insulating ferromagnetic state with an extraordinarily high Curie temperature, TC, of ∼750 K. The emerged ferromagnetic state is associated with charge-disproportionation (CD) and spin-state-disproportionation (SSD), involving high-spin Co2+ and low-spin Co4+ ions. The density functional theory calculation also produces an insulating ferromagnetic state in the strained SCO system, consistent with the CD and SSD, which is associated with the structural ordering in the system. Transpiring the insulating ferromagnetic state through modulating the electronic correlation parameters via strain engineering in the SCO thin film will have a significant impact in large areas of modern electronic and spintronic applications.
Another ‘language that failed’?
Authors: King Ross 
Published: May 2024

Abstract
This paper examines the linguistic features of Korean-language publications issued in the Russian Far East (RFE)
between 1922 and 1937, the year all Koreans in the RFE were deported to Uzbekistan and Kazakhstan, and tries to answer the
questions “Can we speak of a separate ‘Soviet’ Korean written language, and if so, what were its defining characteristics?”
Moreover, “If there was a ‘Soviet’ Korean written language, or at least the appearances of such, was this by
design or by accident?” In order to answer these questions, the paper examines published materials in Korean from the RFE
alongside metalinguistic statements about the Korean language and Korean language policy penned by relevant
Korean intellectuals and Soviet commentators.
The main argument is that we can indeed detect an incipient case of ‘language making’ and the beginnings of a
distinct ‘Soviet Korean’ written language congealing in the years leading up to the deportation of 1937. But this was more by
accident than by design, and owed on the one hand to the peculiar constellation of language policies, Soviet Korean language and
orthographic ideologies, and Korean dialect facts in the RFE, and on the other hand to the relative shallowness of Korean language
standardization on the peninsula itself.
Any further developments in the way of Soviet Korean ‘language making’ were nipped in the bud by the deportation
of 1937 and the discontinuation of Korean language education in schools from 1938. As a result, written Soviet Korean ceased to
exist, and spoken Soviet Korean – Koryŏmal – became completed “unroofed”; the Soviet Koreans became a “rag doll
nation” within the USSR, and spoken Soviet Korean/Koryŏmal became a “rag doll language.”
(Im)polite uses of vocatives in present-day Madrilenian Spanish
Authors: De Latte Fien 
Published: May 2024

Abstract
The present study aims to examine the socio-pragmatic scope of vocatives in present-day colloquial Spanish. As
prototypical deictic markers, directly calling upon the addressee, vocatives are considered crucial mechanisms in the creation and
maintaining of interpersonal relationships during interaction. This deictic potential makes them highly appropriate strategies at
the service of face work and (im)politeness. However, the relation between (Spanish) vocatives and (im)politeness has scarcely
been explored. In an attempt to fill this research gap, the present analysis empirically examines the socio-pragmatic functions
related to the expression of (im)politeness that the Spanish vocative is able to fulfill in colloquial conversations. The results
show that its socio-pragmatic multifunctionality needs to be evaluated in the broad context, not only by taking into account the
hosting speech act and the vocative’s semantic features, but also extra-linguistic parameters, such as the interpersonal
relationship and the speaker’s age.
Massless Dirac perturbations of black holes in f(Q) gravity: quasinormal modes and a weak deflection angle
Authors: Al-Badawi Ahmad , Kumar Jha Sohan 
Published: May 2024

Abstract
This article considers a static and spherical black hole (BH) in f(Q) gravity. f(Q) gravity is the extension of symmetric teleparallel general relativity, where both curvature and torsion are vanishing and gravity is described by nonmetricity. In this study, we investigate the possible implications of quasinormal mode (QNM) modified Hawking spectra and deflection angles generated by the model. The Wentzel–Kramers–Brillouin method is used to solve the equations of motion for massless Dirac perturbation fields and explore the impact of the nonmetricity parameter (Q
0). Based on the QNM computation, we can ensure that the BH is stable against massless Dirac perturbations and as Q
0 increases the oscillatory frequency of the mode decreases. We then discuss the weak deflection angle in the weak field limit approximation. We compute the deflection angle up to the fourth order of approximation and show how the nonmetricity parameter affects it. We find that the Q
0 parameter reduces the deflection angle.
Universal republic or confederation of democracies?
Authors: Koenig-Archibugi Mathias 
Published: May 2024

Abstract
This chapter compares a democratic world state with a confederation of democracies and assesses arguments about their relative normative advantages. It uses machine learning and statistical simulations to predict the level of participatory, deliberative, liberal, and egalitarian democracy that we would expect a hypothetical world polity to have, given the world’s level of ethnic, religious, and linguistic diversity, economic inequality, population size, and other features. The democratic quality of the world state would be comparable and perhaps higher than in the average state. The chapter then assesses concerns that a democratic world state would fail to respect and accommodate the legitimate diversity of policy values among the people of the world, and that it would have a serious problem of persistent minorities. The empirical evidence does not support such concerns. The chapter also presents empirical evidence that governments’ monopoly of international decision-making suppresses the ability of major domestic groups to express distinctive concerns and priorities at the international level.