bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interferon‐α induces unabated production of short‐lived plasma cells in pre‐autoimmune lupus‐prone (NZB×NZW)F1 mice but not in BALB/c mice
Authors: Mathian Alexis , Gallegos Mike , Pascual Virginia , Banchereau Jacques , Koutouzov Sophie 
Published: January 2011

AbstractIFN‐α is known to play a critical role in the pathogenesis of systemic lupus erythematosus (SLE), but the mechanisms remain unclear. We previously showed that within weeks, exposure to IFN‐α in vivo induces lupus in pre‐autoimmune lupus‐prone NZB×NZW F1 (NZB/W) but not in BALB/c mice. In the current study, we show that in vivo expression of IFN‐α induces sustained B‐cell proliferation in both BALB/c and NZB/W mice. In NZB/W but not BALB/c mice, B‐cell proliferation was accompanied by a rapid and unabated production of autoantibody‐secreting cells (ASCs) in secondary lymphoid organs, suggesting that a B‐cell checkpoint is altered in the autoimmune background. The majority (>95%) of ASCs elicited in IFN‐α‐treated NZB/W mice were short‐lived and occurred without the induction of long‐lived plasma cells. A short course of cyclophosphamide caused a sharp drop in IFN‐α‐elicited short‐lived plasma cells, but the levels recovered within days following termination of treatment. Thus, our work provides new insights into effectiveness and limitations of the current SLE therapies.
Tolerance induction towards cardiac allografts under costimulation blockade is impaired in CCR7‐deficient animals but can be restored by adoptive transfer of syngeneic plasmacytoid dendritic cells
Authors: Liu Xiaosun , Mishra Pooja , Yu Songfeng , Beckmann Jan , Wendland Meike , Kocks Jessica , Seth Sebastian , Hoffmann Katharina , Hoffmann Matthias , Kremmer Elisabeth , Förster Reinhold , Worbs Tim 
Published: January 2011

AbstractDeficiency of transplant recipients for the chemokine receptor CCR7 was originally described to slightly increase the survival time of vascularized solid organ grafts, probably due to a reduced priming of alloreactive T cells. Using a model of allotolerance induction by donor‐specific splenocyte transfusion (DST) in combination with anti‐CD40L mAb‐mediated costimulation blockade (CSB), we show here a striking failure of CCR7‐deficient (CCR7−/−) recipients to tolerate cardiac allografts. Furthermore, in addition to the recently described lack of Treg, CCR7−/− mice were found to harbor significantly reduced numbers of plasmacytoid dendritic cells (pDCs) within peripheral as well as mesenteric lymph nodes (LNs), but not the bone marrow or spleen. pDCs had previously been suggested to function as tolerogenic APC during allograft transplantation, and a single transfer of syngeneic WT pDCs, but not conventional DCs, was indeed sufficient to rescue graft survival in DST+CSB‐treated CCR7−/− recipients in a dose‐dependent manner. We therefore conclude that the nearly complete absence of pDCs within LNs of CCR7−/− mice prevents the successful induction of DST+CSB‐mediated allotolerance, leading to the observed acute rejection of cardiac allografts under tolerizing conditions.
Characterization of the immunoregulatory function of human TCR‐αβ+ CD4−CD8− double‐negative T cells
Authors: Voelkl Simon , Gary Regina , Mackensen Andreas 
Published: January 2011

AbstractRegulatory T cells (Tregs) play an important role in the maintenance of immune tolerance to self‐antigens and are involved in modulating immune responses in autoimmunity, transplant rejection, and tumor immunity. Recently, a novel subset of TCR‐αβ+ CD4−CD8− (double negative, DN) T cells has been described to specifically suppress T‐cell responses in mice. Here, we demonstrate that human DN T cells are highly potent suppressors of both CD4+ and CD8+ T‐cell responses. In contrast to naturally occurring CD4+CD25+ Tregs, DN T cells have to be activated by antigen‐presenting cells (APCs) to induce their regulatory potential. The suppressive activity of DN T cells is neither mediated indirectly by modulation of APCs nor by competition for T‐cell growth factors. Furthermore, DN T‐cell‐mediated suppression toward responder T cells is TCR dependent and requires novel protein synthesis. In contrast to murine DN T cells, which eliminate effector T cells via Fas/FasL or perforin/granzyme, human DN T cells suppress proliferation of responder T cells by cell contact‐dependent mechanisms. Taken together, our data indicate that human DN T cells exert strong immunosuppressive effects on both CD4+ and CD8+ T cells and may serve as a new therapeutic approach to treat autoimmunity and transplant rejection.
Chiral Cationic [Cp′Mo(CO)2(NCMe)]+ Species – Catalyst Precursors for Olefin Epoxidation with H2O2 and tert‐Butyl Hydroperoxide
Authors: Reis Patrícia M. , Gamelas Carla A. , Brito José A. , Saffon Nathalie , Gómez Montserrat , Royo Beatriz 
Published: January 2011

AbstractA novel cyclopentadienyl ligand bearing a chiral oxazoline pendant group (Cpox) has been prepared. Its coordination to molybdenum and tungsten afforded optically pure (R)‐CpoxM(η3‐C3H5)(CO)2 (M = Mo, W) in which the pendant oxazoline fragment is not coordinated to the metal center. Reaction of (R)‐CpoxMo(η3‐C3H5)(CO)2 with tetrafluoroboric acid gives the bidentate η5‐cyclopentadienyloxazoline complex [CpoxMo(CO)2(NCMe)]BF4 in which the oxazoline is coordinated through the N‐atom to the molybdenum center. Their catalytic performance in the epoxidation of cis‐cyclooctene, (R)‐limonene, and trans‐β‐methylstyrene with H2O2 and tert‐butyl hydroperoxide (TBHP) as oxidants has been studied. (R)‐CpoxW(η3‐C3H5)(CO)2 displayed high catalytic activity achieving quantitative conversion of cyclooctene epoxide in 2 h with H2O2. [CpoxMo(CO)2(NCMe)]+ has been shown to be an efficient catalyst with TBHP and H2O2, reaching quantitative conversions of the corresponding epoxide in 30 min and 11 h, respectively. ESI‐MS studies of the reaction of [CpoxMo(CO)2(NCMe)]+ with H2O2 and TBHP revealed the in situ formation of the corresponding peroxido [CpoxMo(O2)O]+ and dioxido [CpoxMoO2]+ species, respectively. Further oxidation of these complexes resulted in the loss of the cyclopentadienyloxazoline ligand. Based on spin trap experiments, the involvement of both carbon‐ and oxygen‐centred radicals in the olefin epoxidation catalyzed by [CpoxMo(CO)2(NCMe)]+ has been proved.
Convergent Validity of the Eating Disorder Examination and the Eating Disorder Examination‐Questionnaire Among University Women in Norway
Authors: Reas Deborah L. , Wisting Line , Kapstad Hilde , Lask Bryan 
Published: January 2011

AbstractThe present study compared the Eating Disorder Examination (EDE; 16.0) and the Eating Disorder Examination‐Questionnaire (EDE‐Q; 6.0) and investigated the psychometric properties of the Norwegian translation of the EDE. Fifty‐eight university women aged 19–41 years (mean BMI = 23) were assessed with the EDE and EDE‐Q. Satisfactory internal consistency and inter‐rater reliability were demonstrated for the Norwegian translation of the EDE. Generally high convergent validity between the EDE and EDE‐Q was found, with correlations ranging from 0.60 (Eating Concern) to 0.86 (Weight Concern). Agreement for OBEs and vomiting were excellent, while driven exercising generated lower levels of convergence. Consistent with prior studies, the EDE‐Q generated significantly higher levels of psychopathology, although effect sizes were small. Owing to the significantly higher EDE‐Q scores, it is ill advised to administer these two instruments interchangeably, as this may fail to produce meaningful data. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.
Disordered eating and suicidal intent: The role of thin ideal internalisation, shame and family criticism
Authors: Unikel C , Von Holle A , Bulik CM , Ocampo R 
Published: January 2011

AbstractObjectiveWe explored the effect of thin ideal internalisation, shame proneness and family criticism on disordered eating and suicidal intent in female Mexican adolescents.MethodWe studied a probabilistic sample of 2537 high school students in central Mexico, stratified by marginalisation status and migratory intensity. We used a generalised logistic regression model to estimate the odds of disordered eating and suicidal intent across scores for three predictors: Internalisation of the thin ideal, shame and family criticism.ResultsDisordered eating was reported by 4.2% (95% CI = 0.9–7.5%) and suicidal intent by 13.2% (95% CI = 12.0–14.4%) of girls. The unadjusted odds ratios of any disordered eating for thin ideal internalisation, shame proneness and familial criticism were 1.2, 1.1 and 3.2, respectively. The positive association between thin ideal internalisation and disordered eating remained even after controlling for shame proneness and familial criticism. The association of these variables with suicidal intent was weaker.DiscussionResults support stronger effects for disordered eating than suicidal intent across the three unadjusted predictors. It also highlights the presence of the relationship of criticism and disordered eating in female adolescents from low and middle socio‐economic backgrounds. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.
CHF in a circumferentially non‐uniformly heated tube under low‐pressure and low‐mass‐flux condition (inclined upward flow)
Authors: Ami Takeyuki , Umekawa Hisashi , Ozawa Mamoru , Mishima Kaichiro , Saito Yasushi 
Published: January 2011

AbstractMost investigations on forced convective boiling have been conducted by using uniformly heated round tubes under a vertical upward flow condition, although the actual system has a non‐uniformly heated condition with several tube orientations. The non‐uniformity of the heat flux and tube inclination causes the liquid film distribution, which in turn affects the critical heat flux. In this investigation, the flow and heat‐transfer characteristics were experimentally investigated under non‐uniformly heated conditions along the circumferential direction with a 45° tube inclination. In the experiment, CHF was measured by using two different heated lengths, i.e., 900 and 1800 mm. The experimental results showed a unique tendency of CHF caused by the interrelationship of the non‐uniform heat flux distribution, the tube inclination, and liquid film redistribution. © 2011 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/htj.20333
Thermal therapy and evaluation by a precise temperature control device
Authors: Maruyama Shigenao , Takashima Shigeru , Okajima Junnosuke , Komiya Atsuki , Seki Takashi , Yambe Tomoyuki 
Published: January 2011

AbstractMoxibustion, one of the thermal therapies used in oriental medicine, has several problems, including the fact that temperature distribution over a treatment region is not uniform, the treatment temperature cannot be controlled, and smoke is emitted. To solve these problems, we developed a precise thermal heat transfer control device and applied it to clinical medicine as a substitute for conventional moxibustion. The abdominal heating controller developed in this study has an effect equal to that of moxibustion and can heat the treatment region of human skin uniformly. The treatment effect of the device was evaluated in a clinical experiment, in which we found that these devices can treat ileus, diarrhea, and related disorders. We sought the optimal temperature for thermal therapy with regard to gender, body mass index, and age. We carried out a numerical simulation of temperature distribution inside a human body when the abdominal region is heated. Temperature distribution of the heated abdominal region was calculated using a 2‐D axisymmetric model considering bioheat generation such as blood perfusion and metabolism. The calculation results confirmed that the thermal effect cannot reach the viscera. © 2011 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/htj.20334
Stability of long‐term outcome in bulimia nervosa: a 3‐year follow‐up
Authors: Zeeck Almut , Weber Stephanie , Sandholz Angelika , Joos Andreas , Hartmann Armin 
Published: January 2011

AbstractWe report on the 3‐year course and outcome of patients with bulimia nervosa (BN), initially treated in an inpatient or day clinic setting. Patients were assessed by structured interviews (Structured Clinical Interview for DSM Disorders I and II and Structured Interview for Anorexia and Bulimia Nervosa) and questionnaires (Eating Disorder Inventory‐2, Symptom Checklist‐90‐R, and Social Adjustment Scale) at time points of admission, discharge, and 3‐month, 12‐month and 36‐month follow‐ups. Data of 83.7% of the 43 patients were available. After 3 years, about one third of patients showed complete remission, one third showed partial remission, and one third still fulfilled all the criteria of BN. Most changes occurred during hospitalization. Remission status showed substantial fluctuation over time, with little correlation between time points of assessment (discharge and 3‐month, 12‐month, and 36‐month follow‐ups). A cluster analysis revealed four patterns of longitudinal symptom change. Day clinic and inpatient treatment are overall effective. Longitudinal and repeated assessments are necessary to validly measure outcome in BN. © Wiley Periodicals, Inc. J Clin Psychol 67:1–10, 2011.
SECTORAL GROWTH AND JOB CREATION: EVIDENCE FROM INDONESIA
Authors: Suryadarma Daniel , Suryahadi Asep , Sumarto Sudarno 
Published: January 2011

AbstractWe develop a growth‐employment model that decomposes the Indonesian economy into six components, based on a combination of economic sectors and location, and ascertain the sectors that created the most jobs in Indonesia over the past two decades. We find that urban employment is mostly driven by higher growth in the services sector, especially areas that require skilled personnel. Meanwhile, the agriculture sector growth still drives employment in rural areas, although it appears that the services sector also creates a significant number of jobs. Based on these findings, we provide some policy recommendations. Copyright © 2011 John Wiley & Sons, Ltd.
Ultra‐performance LC‐photodiode array‐eλ‐ESI‐MS/MS screening method for the detection of radical‐scavenging natural antioxidants from Radix et Rhizoma Rhei
Authors: Wang Guo‐Ying , Chen Fang‐Fang , Shi Yan‐Ping 
Published: January 2011

AbstractA novel ultra‐performance LC‐photodiode array‐eλ‐ESI‐MS/MS screening method was developed for the detection and identification of natural antioxidants from Radix et Rhizoma Rhei. Nine compounds were found to possess a potential antioxidant activity, and their free radical‐scavenging capacities were investigated in detail. The nine compounds were identified as 1‐O‐galloyl‐2‐O‐cinnamoylglucose, 6‐hydroxymusizin‐8‐O‐β‐D‐glucopyranoside, (+)‐catechin, gallic acid 3‐O‐β‐D‐glucopyranoside, trans‐3,5,4′‐trihydroxystilbene‐4′‐O‐β‐D‐(2″‐O‐galloyl)‐glucopyranoside, sennoside A, 4‐(4′‐hydroxyphenyl)‐2‐butanone‐4′‐O‐β‐D‐(2″‐O‐galloyl‐6″‐O‐p‐coumaroyl) glucopyranoside, emodin‐8‐O‐(6′‐O‐malonyl) glucopyranoside, and physcion‐8‐O‐β‐D‐glucopyranoside. The reactivity and SC50 values of those compounds were investigated, respectively. 1‐O‐Galloyl‐2‐O‐cinnamoylglucose showed the strongest capability for scavenging 1,1‐diphenyl‐2‐picrylhydrazyl‐free radical; trans‐3,5,4′‐trihydroxystilbene‐4′‐O‐β‐D‐(2″‐O‐galloyl) glucopyranoside showed the strongest capability for scavenging superoxide radical; 4‐(4′‐hydroxyphenyl)‐2‐butanone‐4′‐O‐2‐D‐(2″‐O‐galloyl‐6″‐O‐p‐coumaroyl) glucopyranoside exhibited the highest reactivity in the lipid peroxidation processes. The use of the analytical screening method based on ultra‐performance LC‐photodiode array‐eλ‐ESI‐MS/MS would provide a new way for rapid detection of radical‐scavenging natural compounds from Radix et Rhizoma Rhei or complex matrices.
H‐Phosphonic Acid Derivatives as Catalysts for Reversible Chain Transfer Catalyzed Polymerization (RTCP) at Ambient and High Pressure
Authors: Wolpers Arne , Ackermann Lutz , Vana Philipp 
Published: January 2011

AbstractSeveral H‐phosphonic acid derivatives (PADs) were analyzed regarding their ability to perform as effective catalysts in reversible chain transfer catalyzed polymerization (RTCP), a relatively new type of controlled radical polymerization. Therefore, bulk polymerizations of styrene at 100 °C using different PADs were studied in detail. The obtained number‐average molar masses and polydispersities of the polymeric products showed that a cyclic PAD derived from pinacol was found to be a very well suited catalyst for RTCP under the chosen conditions. In addition, RTCPs at high pressure up to 2000 bar were conducted indicating poor molar mass control compared to the systems at ambient pressure. magnified image
Formation of Thermosets via Molecular Pockets in Thermoplastic Chains: A Simple and Direct Way to Nanospherical Thermosets
Authors: Rungswang Wonchalerm , Chirachanchai Suwabun 
Published: January 2011

AbstractBy curing bisphenol A‐based benzoxazine in a thermoplastic polystyrene‐block‐poly (ethylene‐co‐1‐butene)‐block‐polystyrene (SEBS) block copolymer, nanospherical polybenzoxazines as small as 150 nm with narrow size distribution are obtained in high yield. This specific condition allows simple and direct formation of nano‐ or microspherical thermoset resins. A model of how the thermoplastic block copolymer chains act as a molecular pocket where the thermoset curing proceeds is presented. It is demonstrated that this mechanism requires (i) a particular block of thermoplastic copolymer which allows specific interaction with monomeric thermoset molecules, and (ii) the curing of thermosets in a molecular assembly structure to confine the phase separation of thermoset prepolymer during curing. magnified image
Spherical fractional and hypersingular integrals of variable order in generalized Hölder spaces with variable characteristic
Authors: Samko Natasha , Vakulov Boris 
Published: January 2011

AbstractWe consider non‐standard generalized Hölder spaces of functionsfon the unit sphere\documentclass{article}\usepackage{amssymb}\pagestyle{empty}\begin{document}${\mathbb S}^{n-1} $\end{document}in\documentclass{article}\usepackage{amssymb}\pagestyle{empty}\begin{document}${\mathbb R}^n $\end{document}, whose local continuity modulus Ω(f,x,h) at a point\documentclass{article}\usepackage{amssymb}\pagestyle{empty}\begin{document}$x\in {\mathbb S}^{n-1} $\end{document}has a dominant ω(x,h) which may vary from point to point. We establish theorems on the mapping properties of spherical potential operators of variable order α(x), from such a variable generalized Hölder space to another one with a “better” dominant ωα(x,h) =hℜα(x)ω(x,h), and similar mapping properties of spherical hypersingular integrals of variable order α(x) from such a space into the space with “worse” dominant ω−α(x,h) =h−ℜα(x)ω(x,h). We admit variable complex valued orders α(x) which may vanish at a set of measure zero. To cover this case, we consider the action of potential operators to weighted generalized Hölder spaces with the weight α(x). © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
One Decade of Microwave‐Assisted Polymerizations: Quo vadis?
Authors: Ebner Clemens , Bodner Thomas , Stelzer Franz , Wiesbrock Frank 
Published: January 2011

AbstractThe application of microwave irradiation in polymer syntheses and modifications is of continuously growing interest and has received significant international interest since the beginning of the millennium. Preceded by a review that was published 6 years ago, the present paper summarizes the most recent trends in this research area. Radical as well as step‐growth and ring‐opening polymerizations will be addressed; furthermore, the evolution from microwave‐assisted polymerizations to microwave‐assisted material fabrication will be described on the examples of polymeranalogous reactions, polymer/metal composites and bio‐based materials.
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Glaucasides A–C, three saikosaponins from Atriplex glauca L. var. ifiniensis (Caball) Maire
Authors: Jabrane Aymen , Ben Jannet Hichem , Miyamoto Tomofumi , Tanaka Chiaki , Mirjolet Jean‐François , Duchamp Olivier , Harzallah‐Skhiri Féthia , Lacaille‐Dubois Marie‐Aleth 
Published: January 2011

AbstractFrom the roots of Atriplex glauca L. var. ifiniensis (Caball) Maire (syn. of Atriplex parvifolia Lowe var. genuina Maire), three new saikosaponins designated as glaucasides A–C (1–3) were isolated together with the known 3‐O‐$\bf{\beta}$‐D‐glucopyranosyl‐(1 → 2)‐$\bf{\beta}$‐D‐galactopyranosyl‐saikogenin F (4). The structures of the new compounds were elucidated by extensive analysis of one‐dimensional and two‐dimensional NMR spectroscopy, FABMS, HR‐ESIMS and chemical evidence as 13$\bf{\beta}$,28‐epoxy‐16$\bf{\beta}$,21$\bf{\beta}$‐dihydroxyolean‐11‐en‐3$\bf{\beta}$‐yl O‐$\bf{\beta}$‐D‐[2‐O‐sulfate]‐glucopyranosyl‐(1 → 2)‐$\bf{\alpha}$‐L‐arabinopyranoside (1), 13$\bf{\beta}$,28‐epoxy‐16$\bf{\beta}$,21$\bf{\beta}$‐dihydroxyolean‐11‐en‐3$\bf{\beta}$‐yl O‐$\bf{\beta}$‐D‐[2‐O‐sulfate]‐glucopyranosyl‐(1 → 2)‐$\bf{\alpha}$‐L‐arabinopyranosyl 21‐O‐{4‐(secbutylamido)‐butanoyl ester} (2) and 3‐O‐$\bf{\beta}$‐D‐glucopyranosyl‐(1 → 2)‐$\bf{\beta}$‐D‐galactopyranosyl saikogenin G (3). The cytotoxic activities of these compounds were evaluated against the HT‐29 and HCT 116 human colon cancer cell lines. Copyright © 2011 John Wiley & Sons, Ltd.
1H, 13C, 195Pt and 15N NMR structural correlations in Pd(II) and Pt(II) chloride complexes with various alkyl and aryl derivatives of 2,2′‐bipyridine and 1,10‐phenanthroline
Authors: Pawlak Tomasz , Pazderski Leszek , Sitkowski Jerzy , Kozerski Lech , Szłyk Edward 
Published: January 2011

Abstract1H, 13C, 195Pt and 15N NMR studies of platinide(II) (M = Pd, Pt) chloride complexes with such alkyl and aryl derivatives of 2,2′‐bipyridine and 1,10‐phenanthroline as LL = 6,6′‐dimethyl‐bpy, 5,5′‐dimethyl‐bpy, 4,4′‐di‐tert‐butyl‐bpy, 2,9‐dimethyl‐phen, 2,9‐dimethyl‐4,7‐diphenyl‐phen, 3,4,7,8‐tetramethyl‐phen, having the general [M(LL)Cl2] formula were performed and the respective chemical shifts (δ1H, δ13C, δ195Pt, δ15N) reported. 1H high‐frequency coordination shifts ($\Delta_{\rm {coord}}^{\rm {1H}} = \delta_{\rm {complex}}^{\rm {1H}} - \delta_{\rm {ligand}}^{\rm {1H}}$) mostly pronounced for nitrogen‐adjacent protons and methyl groups in the nearest adjacency of nitrogen, as well as 15N low‐frequency coordination shifts ($\Delta_{\rm {coord}}^{\rm {15N}} = \delta_{\rm {complex}}^{\rm {15N}} - \delta_{\rm {ligand}}^{\rm {15N}}$) were discussed in relation to the molecular structures. Copyright © 2011 John Wiley & Sons, Ltd.
Solid‐state NMR detection of 14N13C dipolar couplings between amino acid side groups provides constraints on amyloid fibril architecture
Authors: Middleton David A. 
Published: January 2011

AbstractSolid‐state nuclear magnetic resonance (SSNMR) is a powerful technique for the structural analysis of amyloid fibrils. With suitable isotope labelling patterns, SSNMR can provide constraints on the secondary structure, alignment and registration of β‐strands within amyloid fibrils and identify the tertiary and quaternary contacts defining the packing of the β‐sheet layers. Detection of 14N13C dipolar couplings may provide potentially useful additional structural constraints on β‐sheet packing within amyloid fibrils but has not until now been exploited for this purpose. Here a frequency‐selective, transfer of population in double resonance SSNMR experiment is used to detect a weak 14N13C dipolar coupling in amyloid‐like fibrils of the peptide H2N‐SNNFGAILSS‐COOH, which was uniformly 13C and 15N labelled across the four C‐terminal amino acids. The 14N13C interatomic distance between leucine and asparagine side groups is constrained between 2.4 and 3.8 Å, which allows current structural models of the β‐spine arrangement within the fibrils to be refined. This procedure could be useful for the general structural analysis of other proteins in condensed phases and environments, such as biological membranes. Copyright © 2011 John Wiley & Sons, Ltd.