bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical predictors of cognitive function in adults treated with hematopoietic cell transplantation
Authors: Jim Heather S. L. , Small Brent , Hartman Sheri , Franzen Jamie , Millay Shannon , Phillips Kristin , Jacobsen Paul B. , Booth‐Jones Margaret , Pidala Joseph 
Published: December 2011

AbstractBACKGROUND:Studies suggest that patients with cancer who undergo hematopoietic cell transplantation (HCT) are at risk for cognitive deficits. To date, little research has investigated the cumulative effects of clinical risk factors on cognitive function in patients who undergo HCT.METHODS:Patients (N = 278) who were scheduled to undergo HCT for hematologic disease completed neuropsychological assessments before HCT and at 6 months and 12 months after HCT. A time‐varying cumulative clinical risk variable was examined as a predictor of total neuropsychological performance (TNP). Cumulative clinical risk was calculated from pre‐HCT neuropsychological risk factors (eg, history of cranial irradiation, intrathecal chemotherapy), HCT‐related risk factors (eg, allogeneic transplantation, unrelated donor), and post‐HCT complications (eg, severity of mucositis and enteritis, graft‐versus‐host disease).RESULTS:Patients with greater cumulative clinical risk displayed worse TNP at baseline and at 6 months after HCT and less neuropsychological recovery over time than patients who had less risk (Ps < .05). Greater cumulative clinical risk predicted worse performance on tasks assessing executive function at baseline and 6 months after HCT and assessing memory at 6 months and 12 months after HCT (Ps < .05). Among risk variables, length of hospital stay was the only significant predictor of neuropsychological function (P < .05).CONCLUSIONS:Findings from this study indicated that clinical risk factors may have a cumulative effect on cognitive function in patients who undergo HCT. Patients who have a complicated clinical course should be referred for evaluation and management of cognitive deficits. Cancer 2011. © 2011 American Cancer Society.
Synthesis of Cyclic Sulfites from Epoxides and Sulfur Dioxide with Silica‐Immobilized Homogeneous Catalysts
Authors: Takenaka Yasumasa , Kiyosu Takahiro , Mori Goro , Choi Jun‐Chul , Fukaya Norihisa , Sakakura Toshiyasu , Yasuda Hiroyuki 
Published: December 2011

AbstractQuaternary ammonium‐ and amino‐functionalized silica catalysts have been prepared for the selective synthesis of cyclic sulfites from epoxides and sulfur dioxide, demonstrating the effects of immobilizing the homogeneous catalysts on silica. The cycloaddition of sulfur dioxide to various epoxides was conducted under solvent‐free conditions at 100 °C. The quaternary ammonium‐ and amino‐functionalized silica catalysts produced cyclic sulfites in high yields (79–96 %) that are comparable to those produced by the homogeneous catalysts. The functionalized silica catalysts could be separated from the product solution by filtration, thereby avoiding the catalytic decomposition of the cyclic sulfite products upon distillation of the product solution. Heterogenization of a homogeneous catalyst by immobilization can, therefore, improve the efficiency of the purification of crude reaction products. Despite a decrease in catalytic activity after each recycling step, the heterogeneous pyridine‐functionalized silica catalyst provided high yields after as many as five recycling processes.
Sex‐specific genetic variances in life‐history and morphological traits of the seed beetleCallosobruchus maculatus
Authors: Hallsson Lára R. , Björklund Mats 
Published: December 2011

AbstractKnowledge of heritability and genetic correlations are of central importance in the study of adaptive trait evolution and genetic constraints. We use a paternal half‐sib‐full‐sib breeding design to investigate the genetic architecture of three life‐history and morphological traits in the seed beetle,Callosobruchus maculatus. Heritability was significant for all traits under observation and genetic correlations between traits (rA) were low. Interestingly, we found substantial sex‐specific genetic effects and low genetic correlations between sexes (rMF) in traits that are only moderately (weight at emergence) to slightly (longevity) sexually dimorphic. Furthermore, we found an increased sire () compared to dam () variance component within trait and sex. Our results highlight that the genetic architecture even of the same trait should not be assumed to be the same for males and females. Furthermore, it raises the issue of the presence of unnoticed environmental effects that may inflate estimates of heritability. Overall, our study stresses the fact that estimates of quantitative genetic parameters are not only population, time, environment, but also sex specific. Thus, extrapolation between sexes and studies should be treated with caution.
Iron Coordination Chemistry of N2Py2 Ligands Substituted by Carboxylic Moieties and Their Impact on Alkene Oxidation Catalysis
Authors: Oddon Frédéric , Girgenti Elodie , Lebrun Colette , Marchi‐Delapierre Caroline , Pécaut Jacques , Ménage Stéphane 
Published: December 2011

AbstractA biomimetic approach based on Rieske dioxygenase mimics has been undertaken, which uses the tetradentate N2Py2 ligand platform that contains two pyridine moieties linked to a 1,2‐diaminoethane or a trans‐1,2‐diaminocyclohexane backbone. Here we report the impact of the incorporation of carboxylic functionalities with the N2Py2 ligand on the catalytic efficiency of its FeII complexes during epoxidation with H2O2 as the oxidant. Five complexes have been characterized in the solid state and solution. The X‐ray structure of a ferrous complex with a ligand that contains two carboxylic acid moieties shows an unexpected N4O3‐type iron coordination sphere. Moreover, the two carboxylic groups of the ligand remain protonated and bound by its sp2 oxygen atom. Two substitutions of the ligand with carboxylic moieties was found to be deleterious to the reactivity of the complex during alkene oxidation, whereas monosubstitution led to a slight change in the reactivity. Moreover, the catalyst built from the optically active trans‐1,2‐diaminocyclohexane backbone, L3, catalyzes the asymmetric epoxidation of trans‐2‐heptene with up to 17 % yield. The addition of acetic acid leads to better selectivity, enantioselectivity (38 %), and yield of the epoxidation of nonaromatic alkenes.
Microwave‐Assisted Cerium(III)‐Promoted Cyclization of Propargyl Amides to Polysubstituted Oxazole Derivatives
Authors: Bartoli Giuseppe , Cimarelli Cristina , Cipolletti Roberto , Diomedi Simone , Giovannini Riccardo , Mari Margherita , Marsili Laura , Marcantoni Enrico 
Published: December 2011

AbstractFunctionalized polysubstituted oxazoles are an important class of five‐membered N,O‐heterocycles that occur widely in the structure of natural products and fine chemicals. They are also often used as building blocks in the synthesis ofheterocyclic molecules with more complex structures. Therefore, efficient synthetic protocols based on Lewis acid promoted reactions are desirable. In this context, we report that, under microwave irradiation, the CeCl3·7H2O/NaI/I2 system is capable of promoting a 5‐exo‐dig cyclization of propargyl amides with good functional group tolerance. The microwave reactor also provides a more convenient and safer method for heating the reaction. This methodology represents a straightforward CeCl3·7H2O/NaI/I2 promoted cyclization using microwave irradiation to accomplish the synthesis of polysubstituted oxazole derivatives.
Reconstructing paleoenvironments and palaeoclimates in drylands: what can landform analysis contribute?
Authors: Thomas David S. G. 
Published: December 2011

ABSTRACTQuaternary period palaeoenvironmental and palaeoclimatic reconstructions are based on a wide and diverse array of proxy data sets, some of which are geomorphological in nature. In drylands, where organic proxies may be limited, the use of landforms is particularly important, but challenging. The capacity to establish the age of depositional forms, particularly through the use of luminescence dating, has advanced the use of landforms in dryland palaeo‐research, though interpretation of these ‘geoproxy’ records can be complex, especially at the nexus of palaeoclimate and palaeoenvironmental interpretations of past conditions. In this paper the use of aeolian and lacustrine forms in Quaternary research is considered, focusing on the relationships between dynamics, form and climate, and on the essential linkage between process research and palaeoenvironmental research. It is concluded that landform analysis is a critical part of dryland palaeoenvironmental/climate reconstruction, contributing a different set of data compared to other data sources, in terms of the elements of past conditions that are revealed. Five principles are identified to improve the use of geoproxy records in Quaternary research: (1) greater use of geomorphic process studies by Quaternary scientists, to better inform palaeolandform interpretation; (2) further development of the use of chronometric data, especially in terms of interpreting large data; (3) interpret landform records in location‐specific contexts, not in general terms; (4) capitalise of the complexity of spatially‐extensive landform records, which may offer better representations of real Quaternary environmental complexity than ‘at a point’ proxies; (5) establish ways of integrating spatially‐extensive geoproxy records with other palaeoenvironmental records. These challenges are major, but not insurmountable, and should represent goals for geomorphologists, chronologists and quaternary scientists alike. Copyright © 2011 John Wiley & Sons, Ltd.
Thermochemical properties and phase behavior of halogenated polycyclic aromatic hydrocarbons
Authors: Fu Jinxia , Suuberg Eric M. 
Published: December 2011

Abstract
Knowledge of vapor pressure of organic pollutants is essential in predicting their fate and transport in the environment. In the present study, the vapor pressures of 12 halogenated polycyclic aromatic compounds (PACs), 9-chlorofluorene, 2,7-dichlorofluorene, 2-bromofluorene, 9-bromofluorene, 2,7-dibromofluorene, 2-bromoanthracene, 9-chlorophenanthrene, 9-bromophenanthrene, 9,10-dibromophenanthrene, 1-chloropyrene, 7-bromobenz[a]anthracene, and 6,12-dibromochrysene, were measured using the Knudsen effusion method over the temperature range of 301 to 464 K. Enthalpies and entropies of sublimation of these compounds were determined via application of the Clausius–Clapeyron equation. The data were also compared with earlier published literature values to study the influence of halogen substitution on vapor pressure of PACs. As expected, the halogen substitution decreases vapor pressure compared with parent compounds but does not necessarily increase the enthalpy of sublimation. Furthermore, the decrease of vapor pressure also depends on the substitution position and the substituted halogen, and the di-substitution of chlorine and/or bromine decreases the vapor pressure compared with single halogen-substituted polycyclic aromatic hydrocarbons. In addition, the enthalpy of fusion and melting temperature of these 12 PACs were determined using differential scanning calorimetry and melting point analysis. Environ. Toxicol. Chem. 2012;31:486–493. © 2011 SETAC
Accumulation of PAHs and synthetic musk compound in minke whales (Balanoptera acutorostrata) and long-beaked common dolphins (Delphinus capensis) from Korean coastal waters
Authors: Moon Hyo-Bang , An Yong-Rock , Choi Seok-Gwan , Choi Minkyu , Choi Hee-Gu 
Published: December 2011

Abstract
Information on the occurrence and accumulation profiles of polycyclic aromatic hydrocarbons (PAHs) and synthetic musk compounds (SMCs) in marine mammals is scarce. In the present study, we recorded the concentrations and profiles of PAHs and SMCs in liver tissue and blubber from minke whales and common dolphins from Korean coastal waters. The overall concentrations of PAHs and SMCs in blubber from both cetacean species were approximately three to five times higher than those in liver tissues. Residue levels of PAHs were lower, whereas levels of SMCs were relatively higher than those reported in other studies. Lack of species- and sex-dependent differences in the concentrations of PAHs and SMCs were found. Naphthalene and 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-r-2-benzopyran (HHCB) were predominant compounds in all the samples for PAHs and SMCs, respectively. The concentrations of PAHs and SMCs were significantly correlated with each other, but were not correlated with body size of cetaceans. The present data provide valuable information on the exposure of Korean cetaceans to PAHs and SMCs. Environ. Toxicol. Chem. 2012;31:477–485. © 2011 SETAC
The most common plant species in temperate Europe based on frequency of occurrences in the national grid mapping projects
Authors: Seregin Alexey P. 
Published: December 2011

AbstractThe lists of the top 100 most common plant species in the floras of nine regions (northern Scotland, southern England, southern Germany, northern Germany, Poland, Estonia, Vladimir Oblast (Russia) with Norway and Switzerland forming an outer group) were analyzed. These lists are based on either national or regional floristic grid mapping projects. The general ranking of species within the united list is based on two criteria – the number of floras where the species is one of the top 100 most common species and the sum of ranks within these floras. Trifolium repens, Achillea millefolium, and Urtica dioica should be regarded as the most common native species all over temperate Europe, while Matricaria discoidea and Erigeron canadensis are the most successful aliens here. The alien plant species contribute significantly less in the European flora and vegetation rather than the most successful natives (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Wolffiella hyalina (Delile) Monod (Lemnaceae) – A New Record for the Flora of Saudi Arabia
Authors: Masrahi Yahya S. , Al‐Turki Turki A. , Sayed Osama H. 
Published: December 2011

AbstractThe present paper reports the first record of the aquatic monocotyledon plant Wolffiella hyalina (Delile) Monod (Lemnaceae) in Saudi Arabia. The species was cited floating on the surface of rainwater‐filled deep mountain pools at Sala Mountain south west of Saudi Arabia. This species has previously only been cited in Africa and India. The present citation, therefore, can be regarded as an addition to the flora of Saudi Arabia (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Stomata dimorphism in dicotyledonous plants of temperate climate
Authors: Boldt Katja M. , Rank Barbara 
Published: December 2011

AbstractThe leaves of many tropical trees have besides the normal stomata abnormally large stomata long described as “giant stomata.” They reflect an additional early phase of stomata initiation during leaf ontogeny. In epidermal replicas from more than 200 dicotyledonous species of temperate climate we also found well defined giant stomata or solitary stomata of normal size in the majority of woody plants, but rarely in herbaceous plants. There is no relationship between taxonomic group and presence of giant stomata.
Vergleichsberechnungen zur Dalbenbemessung nach Blum und mit der p‐y‐Methode
Authors: Rudolph Christina , Mardfeldt Björn , Dührkop Jan 
Published: December 2011

AbstractIn Deutschland werden Dalben in der Regel auf Grundlage der EAU 2004 mit dem Verfahren nach Blum mit räumlichem Erdwiderstand nach DIN 4085 bemessen. International wird dagegen eher die p‐y‐Methode verwendet. Zukünftig soll auch in Deutschland die p‐y‐Methode zur Dalbenbemessung angewandt werden. Für den Anwender stellt sich die Frage der Vor‐ und Nachteile beider Verfahren im konkreten Anwendungsfall. In diesem Beitrag werden die theoretischen Grundlagen gegenübergestellt. Ein Bemessungsbeispiel zeigt, welche Auswirkung die Anwendung der beiden Verfahren auf die Abmessungen, Schnittgrößen und Verformungen des Dalbens hat. Somit liefert dieser Beitrag eine Entscheidungshilfe bei der Dalbenbemessung.Comparative calculations on dolphin design using the Blum method and the p‐y‐method. In Germany dolphins are commonly designed using a procedure after Blum, 1932, proposed in the EAU 2004. However, internationally the p‐y‐method is applied more widely for dolphin design. In future, legislature in Germany will change towards allowing the p‐y‐method besides the Blum‐method. For the practioning engineer this raises the question of advantages and disadvantages of both methods. This paper contrasts the underlying principles and presents examples for design calculations to allow for comparison of the two methods.
Innerstädtischer Neubau einer Hochgeschwindigkeitsstrecke für die Eisenbahn in China – der Shijiazhuang City Tunnel und das neue Terminal als Teil der Beijing‐Shijiazhuang‐Wuhan PDL
Authors: Meyer Anna‐Maria , Frühauf Johannes , Gao Jinfa 
Published: December 2011

AbstractDer Shijiazhuang City Tunnel und das neue Terminal sind Teile der Eisenbahnhochgeschwindigkeitsneubaustrecke Beijing‐Shijiazhuang‐Wuhan. Von der Gesamtmaßnahme wurde dieser Bereich getrennt, da die Durchquerung des Stadtgebiets von Shijiazhuang, der Bau des rund 5 km langen Stadttunnels und des neuen Großbahnhofs, der Umbau eines Zugdepots sowie Anschlüsse an bestehende Strecken besondere Anforderungen an die Baumaßnahme stellten. Durchgeführt wird das Projekt von der Eisenbahnverwaltung Beijing. Aufgrund der innerstädtischen Lage und der Unterquerung zahlreicher Straßen‐ und Eisenbahntrassen galt ein besonderes Augenmerk dem Zusammenspiel zwischen Baugrund und Bauwerk und dem daraus resultierenden Setzungs‐ und Verformungsverhalten während der Baumaßnahme und im Nachgang (“Restsetzung”). Um die hohen Anforderungen bezüglich der Qualität der Maßnahme zu sichern, galt es seitens der ausländischen Beteiligung, neben der Beratung in einzelnen technischen Fragen, das Qualitätsmanagement zu verbessern und dessen Umsetzung vor Ort zu kontrollieren.Inner‐city construction of a new high‐speed railway line in China – Shijiazhuang City Tunnel and new Terminal as part of the Beijing‐Shijiazhuang‐Wuhan PDL. Shijiazhuang City Tunnel and new Terminal are part of the newly‐build Beijing‐Shijiazhuang‐Wuhan PDL (Passenger dedicated Line). Due to the special requirements of inner city construction, the construction of around 5 km long city tunnel and of a new major train station, reconstruction of train depot and connection to existing lines, the section has been separated from Beijing‐Shijiazhuang and Shijiazhuang‐Wuhan (Hebei) PDL and executed by Beijing Railway Administration. Special attention has been put on the interaction between subsoil and civil structure and resulting settlement and deformation behaviour during construction and later‐on (‘rest settlement’), especially in the area of crossings with major roads and railway lines. High requirements also apply to the quality of construction. Beside the consultation for special technical topics it was the task of foreign consultants to improve the quality management and check its implementation on site.
Carotid atherosclerosis and chronic hepatitis C: A prospective study of risk associations
Authors: Petta Salvatore , Torres Daniele , Fazio Giovanni , Cammà Calogero , Cabibi Daniela , Di Marco Vito , Licata Anna , Marchesini Giulio , Mazzola Alessandra , Parrinello Gaspare , Novo Salvatore , Licata Giuseppe , Craxì Antonio 
Published: December 2011

Abstract

There are contrasting results in studies of cardiovascular risk in patients with genotype 1 chronic hepatitis C (G1 CHC). We evaluated the prevalence of carotid atherosclerosis compared with a control population in order to assess the potential association between atherosclerosis, host and viral factors, and liver histological features. In all, 174 consecutive biopsy-proven G1 CHC patients were evaluated by anthropometric and metabolic measurements and 174 patients attending an outpatient cardiology unit were used as controls. Intima-media thickness (IMT) and carotid plaques, defined as focal thickening of >1.3 mm at the level of common carotid, were evaluated using ultrasonography. All G1 CHC biopsies were scored by one pathologist for staging and grading, and graded for steatosis. Carotid plaques were found in 73 (41.9%) G1 CHC patients compared with 40 (22.9%) control patients (

P

< 0.001). Similarly, G1 CHC patients had a greater IMT compared with control patients (1.04 ± 0.21 versus 0.90 ± 0.16;

P

< 0.001). Multivariate logistic regression analysis showed that older age (odds ratio [OR] 1.047, 95% confidence interval [CI]: 1.014-1.082,

P

= 0.005), and severe hepatic fibrosis (OR 2.177, 95% CI: 1.043-4.542,

P

= 0.03), were independently linked to the presence of carotid plaques. In patients ≤55 years, 15/67 cases with F0-F2 fibrosis (22.3%) had carotid plaques, compared with 11/21 (52.3%) with F3-F4 fibrosis (

P

= 0.008). By contrast, in patients >55 years the prevalence of carotid plaques was similar in those with or without severe fibrosis (25/43, 58.1% versus 22/43, 51.1%;

P

= 0.51).

Conclusion:

Severe hepatic fibrosis is associated with a high risk of early carotid atherosclerosis in G1 CHC patients. (Hepatology 2012)
Association of thiazolidinediones with liver cancer and colorectal cancer in type 2 diabetes mellitus
Authors: Chang Chia-Hsuin , Lin Jou-Wei , Wu Li-Chiu , Lai Mei-Shu , Chuang Lee-Ming , Chan K. Arnold 
Published: December 2011

Abstract

The objective of this nationwide case-control study was to evaluate the risk of specific malignancy in diabetic patients who received thiazolidinediones (TZDs). A total of 606,583 type 2 diabetic patients, age 30 years and above, without a history of cancer were identified from the Taiwan National Health Insurance claims database during the period between January 1 2000 and December 31 2000. As of December 31 2007, patients with incident cancer of liver, colorectal, lung, and urinary bladder were included as cases and up to four age- and sex-matched controls were selected by risk-set sampling. Logistic regression models were applied to estimate the odds ratio (OR) and 95% confidence interval (CI) between TZDs and cancer incidence. A total of 10,741 liver cancer cases, 7,200 colorectal cancer cases, and 70,559 diabetic controls were included. A significantly lower risk of liver cancer incidence was found for any use of rosiglitazone (OR: 0.73, 95% CI: 0.65-0.81) or pioglitazone (OR: 0.83, 95% CI: 0.72-0.95), respectively. The protective effects were stronger for higher cumulative dosage and longer duration. For colorectal cancer, rosiglitazone, but not pioglitazone, was associated with a significantly reduced risk (OR: 0.86; 95% CI: 0.76-0.96). TZDs were not associated with lung and bladder cancer incidence, although a potential increased risk for bladder cancer with pioglitazone use ≥3 years could not be excluded (OR: 1.56; 95% CI: 0.51-4.74).

Conclusion:

The use of pioglitazone and rosiglitazone is associated with a decreased liver cancer incidence in diabetic patients. The effects on occurrence of specific cancer types may be different for pioglitazone and rosiglitazone. (Hepatology 2012;)