bluuebunny/crossref_metadata_2025_split huggingface dataset:
P02-363 - Changes in Cognitive Functioning During Group Psychodynamic Psychotherapy with Young Psychotic Patients
Authors: Restek Petrović B. , Bogović A. , Silić A. , Mihanović M. , Grah M. , Kezić S. 
Published: June 2010

ObjectivesCognitive impairment is considered to be one of the central features of schizophrenia and it has been so since original descriptions of illness by Kraepelin and Bleuler. Deficits are already present at the first-episode of illness. Some researches conclude that deficits do not change over time, while others suggest that deficits can be reduced. The objective of this research is comparison of cognitive functions of psychotic patients who participated group psychotherapy with those ho did not.MethodIn this paper, by means of Revised Beta Examination (measure of non-verbal intellectual ability) we observe changes in cognitive functioning of 29 psychotic patients who participated in the psychodynamic group psychotherapy within the Early Interventions Program and compare their cognitive achievements with results of matched 32 psychotic patients who received “treatment as usual”. Answers were analyzed qualitatively and quantitatively.ResultsImprovement in cognitive functions was observed in both investigated and control group, but improvement in patients who are participants of long-term psychodynamic group psychotherapy was better than in the group of patients who were not treated in that manner with statistical significance.ConclusionsPsychiatric hospital “Sveti Ivan” offers an extensive outpatient Early Intervention Program for psychotic patients in the critical period of their illness - up to five years from onset. The program includes psychoeducation workshops for the patients and their family members together, group psychodynamic psychotherapy for the patients and group psychotherapy for the family members. Our results indicate better effectiveness of Program when compared to “treatment as usual”.
P02-364 - Efficacy of Ultra-brief Cognitive-Behavioural Therapy in Depressed Inpatients
Authors: Rieu J. , Bui E. , Birmes P. , Schmitt L. 
Published: June 2010

ObjectivesFew studies have suggested the efficacy of cognitive-behavioural therapy (CBT) in inpatients suffering from major depressive disorder (MDD). The present study aims at examining the efficacy of Ultra-brief CBT (UCBT) in depressed inpatients.MethodsTwenty-two patients (age>18) admitted to the psychiatric ward of Toulouse University Hospital for MDD were randomised to receive for two weeks either UCBT (n=11) or treatment as usual (TAU) (n=11). UCBT consisted in 6 sessions of CBT while TAU consisted in supportive sessions. Both types of sessions were performed by psychiatric residents. Both groups also received pharmacological and institutional cares. Primary outcome was depressive symptoms assessed by the Beck Depression Inventory (BDI-II) and the Hamilton Depressive Rating Scale (HDRS) before and after treatment (2 weeks).ResultsThere were no differences between the groups on any baseline variables. Mean age was 48.4 (SD=12.7) and 36.4% (n=8) were of male gender. Mean baseline HDRS scores were 23.3(SD=6.3) and 19.3(SD=3.9) and BDI scores were 36.7(SD=12) and 36.1(SD=7.5) for the UCBT and TAU groups respectively. At the end of treatment, mean HDRS scores were 12.3(SD=10.1) and 14.4(SD=7.8) and BDI scores were 18.8(SD=16.8) and 20.6(SD=11.4) for the CBT and TAU groups respectively. Both groups displayed a significant decrease on HDRS and BDI scores (all p< 0.05). An analyse of variance showed an interaction time by group in favour of the UCBT group on HDRS score (F=6.66; p=0.018).ConclusionOur results suggest that UCBT might be more efficacious than supportive therapy in depressed inpatients.
P02-367 - Towards A New Theoretical Framework for Cognitive-Behavioral Therapy (CBT)
Authors: Varga S. 
Published: June 2010

Cognitive-Behavioural Model (CBT) has become something like the predominant paradigm in psychotherapy. When examining national recommendations (fx UK), there is little doubt that CBT is promoted as the therapy of choice and the preferred first line treatment for depression, eating disorders, panic disorder and obsessive-compulsive disorder.The main aim of my talk is to revise the theoretical foundations of CBT. I will proceed in three steps. First, I will argue that CBT is in part based on misleading philosophical assumptions. These are:(1)Emotional experiences and feelings are caused by beliefs(2)Beliefs involve representational statesSecond, drawing on new developments in the philosophy and neuroscience of emotions, I will attempt to construct a new and more coherent theoretical framework for CBT and work out some of the practical consequences.
P03-105 - Lack of Association Between Cognitive Changes in the First Episode Psychotic Patients and Schizophrenics
Authors: Pešić D. , Janĉić D. , Peruniĉić I. , Mandić-Maravić V. , Kostić M. , Marjanović S. , Leĉić-Toševski D. 
Published: June 2010

ObjectivesVarious studies have demonstrated that psychotic patients have poor performance on the Wisconsin Card Sorting Test (WCST), which serves as an indicator of the dorsolateral prefrontal cortex executive functioning. The aim of our study was to compare cognitive performance of patients suffering from chronic psychosis with the first episode patients.MethodOur sample consisted of chronic schizophrenic and schizoaffective patients in worsening phase, the first episode patients and corresponding healthy controls. All patients were tested by WCST in the second week after the hospitalization, were treated with SGA, and had PANSS score above 60.ResultsThe performance of the psychotic patients was equal to the performance of healthy controls in all variables of the WCST, except the average non-perseverative responses (NPR) (p=0.01). NPR score indicates a state rather than shift in a cognitive set, so we performed the analysis of the given working memory test per diagnosis of the patients. The results showed lack of significant difference in the WCST performance between schizophrenic, schizoaffective and healthy subjects, whereas the first episode patients performed significantly worse then controls in the following variables: categories, perseverative errors and conceptualization level (p< 0.05).ConclusionsOur findings showed difference in cognitive functioning between first episode patients and chronic psychotic patients. Better cognitive performance of chronic psychotic patients could be explained by potentially beneficial effects of the SGA pharmacotherapy to the cognitive status. However, this finding may be also limited by its association with age and relatively modest PANSS scores.
P03-109 - Postpartum Psycosis
Authors: Ramos A. , Cintra P. , Lobo R. 
Published: June 2010

Ever since Hippocrates that it is acknowledged that post-partum represents a period of vulnerability for a number of psychiatric conditions in women, including postpartum psychosis.In this poster, following a discussion of a clinical case of postpartum psychosis, we make a revision of the issue, with historical background, discussion of classification and nosologic status within international classification systems, epidemiology, risk factors, clinical presentation, treatment and prognosis.The method used consisted in revision of literature, research of scientific articles on medline, consultation of gynecology clinical file and inpatient obstetrics and psychiatry clinical files.From our research, we emphasize that postpartum psychosis is accountable for a small fraction of psychiatric morbidity in post-partum, occurring more frequently in primiparas, and women with similar psychiatric antecedents. Even thought there may be different clinical presentations, affective symptoms, state of conscience fluctuations and mood congruent delusions are typical. Several studies suggest that most cases are associated to bipolar disease.Postpartum psychosis is a medical emergence. Fast identification and evaluation are crucial to implement multidisciplinary obstetrics and psychiatric care, involving family and providing adequate social support.
P03-111 - Influence of Psychodynamic Group Oriented Psychotherapy on Quality of Life in Patients with Psychotic Disorders
Authors: Restek Petrović B. , Orešković-Krezler N. , Bogović A. , Mihanović M. , Grah M. , Mayer N. 
Published: June 2010

ObjectivesGroup psychotherapy along with psychopharmacological therapy and sociotherapy is an important and frequently applied therapeutic method. Numerous studies indicate that group psychotherapy affects the functioning in patients with psychotic disorders in terms of improving the cognitive, emotional and social functioning and generally contributes to a better quality of life (Kanas, 1996).The aim of this study was to assess the impact of psychodynamic oriented group psychotherapy on the quality of life in patients with psychotic disorders and to compare the obtained results with the results of patients with psychotic disorders who did not participate in psychodynamic group psychotherapy.MethodPatients included in this study have completed psychotherapy group five years ago and were in regular outpatient treatment together with regular application of medication therapy. The applied method was Quality of Life Scale (Krizmanić, Kolesarić). Answers were analyzed qualitatively and quantitatively.ResultsThe quality of life in the group of patients who completed long-term psychodynamic group psychotherapy was better than in the group of patients who were not treated in that manner, although there are no statistically significant differences. The most important differences were in the area of intimacy, professional occupation and in the area of family relations.ConclusionIt can be concluded that long-term psychodynamic group psychotherapy has a positive influence on quality of life of patients with psychotic disorders.
P03-112 - Gender Differences in Brief Psychotic Disorder
Authors: Rodríguez R. , Roca A. , Ramos I. , Pujol C. , Piñeiro B. 
Published: June 2010

IntroductionBrief Psychotic Disorder (BPD) is a disease characterized by sudden onset of psychotic symptoms. This disturbance lasts at least 1 day but less than 1 month, and the subject fully recovered premorbid level. In the literature there are few data on its prevalence, established between 4-10% of all psychotic disorders. Although a female preponderance has been postuled, gender differences have not been well studied. Therefore, the aim of the present study is to examined sex differences in brief psychotic disorder.MethodWe conducted a retrospective study to estimate the gender differences in an inpatient psychiatric sample. This sample (n=39) included acute patients admitted in a psychiatry ward with diagnosis of brief psychotic disorder. The clinical and socio-demographic characteristics were analysed for males and females separately.ResultsOf a total of 39 patients with BPD, 74.4% were women (n = 29) and 25.6% male (n = 10). Mean age at diagnosis was 33 +/- 8.65 years. Of the clinical variables studied, none was significantly different between male and female. Men had a higher consumption of alcohol (p< 0’05); there were no differences in axis II. Males had more psychiatric family history (70% vs 48.3%), although not statistically significant. Women had more frequent family history of mood disorders and men of psychotic disorders (p < 0.05).ConclusionWe found higher prevalence of BPD in women. Males had more family history (mostly psychotic) and more toxic dependence. Further studies are needed with larger samples to determine the existence of sex differences.
P03-115 - High Incidence of Hyperprolactinemia in Polish Patients with the First Episode of Schizophrenia Participating in EUFEST Study
Authors: Rybakowski J. , Formanowicz J. , Olajossy M. , Jarema M. 
Published: June 2010

ObjectiveThe aim of the study was an analysis of prolactin concentration in the course of antipsychotic treatment in Polish patients participating in EUFEST study.MethodsSeventy-eight patients with the first episode of schizophrenia were studied, randomly allocated to the treatment with low dose haloperidol (n=23), amisulpride (n=21), olanzapine (n=22), quetiapine (n=11) or ziprasidone (n=1), for the period of 12 months. Prolactin concentration was assessed at baseline and after 6 and 12 months of treatment. Hyperprolactinemia was defined as prolactin concentration >18 ng/ml in males and >25 ng/ml in females.ResultsAt baseline, the mean prolactin concentration was 56,5 ng/ml and hyperprolactinemia was observed in 86% of patients, slightly more than in the whole EUFEST group (71%). Prolactin concentration was similar in drug-naïve as in non-drug-naïve patients. After 6 month of treatment, hyperprolactinemia was found in 67% of patients, lowest in haloperidol (29%) and highest in amisulpride group (93%). After 12 months, hyperprolactinemia was observed in 56% of patients, lowest in quetiapine (36%) and highest in amisulpride group (80%).ConclusionHyperprolactinemia was found in a majority of patients with the first episode of schizophrenia, including drug-naïve patients. In the course of one-year antipsychotic treatment, in patients receiving amisulpride, the hyperprolactinemia has been maintained at the initial high level while in remaining groups, a reduction by about 50% of the number of patients having hypeprolactinemia at baseline was observed. We suggest that an abnormality of stress system, could contribute to hyperprolactinemia independent of antipsychotic treatment in the first episode schizophrenic patients.
P03-116 - Training of Affect Recognition (TAR) and Functional Outcome in Schizophrenia
Authors: Sachs G. , Winklbaur B. , Frommann N. , Wölwer W. 
Published: June 2010

ObjectivesAn increasing number of studies focus on general deficits in identifying, differentiating and recalling of facial emotions in schizophrenia. According to preliminary results antipsychotics alone show only little effect on social cognition. We investigated the effects of new antipsychotics when combined with a computer-based training on affect recognition.MethodsSchizophrenic patients (n=20) receiving treatment with new antipsychotics in combination with a six-week Training on Affect Recognition (TAR) were compared with a randomized group of patients (n=18) receiving Treatment As Usual (TAU). Effects on social cognition were tested with the Vienna Emotion Recognition Tasks (VERT-K). In addition, we investigated neurocognitive performance using the Wisconsin Card Sorting Test (WCST), Testbattery for Attentional Performance (TAP): “Alertness”, “Vigilance” and “Working memory”. Negative symptoms and quality of life were assessed using the Positive and Negative Syndrome Scale (PANSS) and the short version of the WHO-Quality of Life Questionnaire (WHOQOL-Bref).ResultsIn comparison to the control group the TAR group showed significant improvements in regard to affect recognition in general as well as in recognizing sad and happy faces. In addition, we found significant improvements for the TAR group regarding executive functions, quality of life and negative symptoms.DiscussionTreatment with new antipsychotics alone has only a limited impact on social cognition. A specific combined treatment of new antipsychotics and TAR leads to improved cognition and emotional performance with additional positive effects on functional outcome.
P03-118 - Perceived Negative Attitude Associates with Psychotic Experiences
Authors: Salokangas R.K.R. , Heinimaa M. , Klosterkötter J. , Ruhrmann S. , Graf von Reventlow H. , Linsze D. , Dingemans P. , Birchwood M. , Patterson P. 
Published: June 2010

ObjectivesRisk of psychosis is defined by the presence of positive psychotic-like symptoms. In clinical examination, easily detectable perceived negative attitude of other people may also indicate risk of psychosis.MethodsA random sample of psychiatric outpatients completed the PROD screen including questions on interpersonal relationships, functioning and subtle specific (psychotic-like) symptoms. Vulnerability to psychosis (VTP) was assessed employing specific symptoms of the PROD screen. Current risk of psychosis (CROP) was assessed using the BSABS and the SIPS/SOPS. The CROP patients were followed up for 18 months and transition to psychosis was detected. The association between perceived negative attitude of others and reported psychotic symptoms was tested in a random sample drawn from the general population.ResultsIn all, 790 outpatients were screened. Of them, 219 VTP and 55 CROP patients were identified. By follow-up, six CROP patients (11 %) had made the transition to psychosis. Vulnerability to psychosis associated with all items of interpersonal relationships and functioning. However, current risk and transition to psychosis associated only with subjectively reported negative attitude of others. In a general population sample, negative attitude of others strongly associated with reported life-time psychotic symptoms conforming thus results obtained from a patient sample.ConclusionThe subjective experience of negative attitude of other people towards oneself associates with experience of psychotic symptoms and may predict more sever psychotic development. The association between perceived negative attitude and occurrence of subtle psychotic symptoms seems to be detectable both in general and patient populations.
P03-122 - Cognitive Rehabilitation in Executive Functioning and Processing Speed in Schizophrenia and First-Episode Psychosis
Authors: Ojeda N. , Peña J. , Bengoetxea E. , Segarra R. , Sánchez P.M. , Elizagárate E. , García J. , Eguiluz J.I. , Ezcurra J. , Gutiérrez M. 
Published: June 2010

ObjectivesProcessing speed and executive functioning are among the more impaired cognitive domains in schizophrenia, do not improve despite antipsychotic medication, and are associated with poor long-term functioning and quality of life. Cognitive remediation therapy for psychosis (REHACOP) try to improve cognitive deficits by teaching information processing strategies through guided mental exercises. The objective of this study is to evaluate the effectiveness of cognitive remediation therapy (REHACOP), compared to other treatments, on processing speed and executive functioning difficulties.Material and methodsFifty-seven patients with DSM-IV schizophrenia and 29 with first-episode psychosis were randomly allocated into one of two groups: Cognitive rehabilitation group (REHACOP) or occupational therapy group. The REHACOP group received 3 months structured group rehabilitation sessions (3 per week) focused on tasks requiring attention, language, memory, speed, executive functioning and activities of daily living. All subjects underwent a neuropsychological assessment pre- and post treatment, which included tests for processing speed (Trail-Making Test-A, Digit Symbol, and Stroop-Color) and executive functioning (Stroop Word-Color part and interference)ResultsRepeated measures of MANOVA showed that the interaction term groupXtime was significant for the executive functioning (F = 9.88, p < 0.01) and processing speed (F = 5.92, p < 0.05) measures, suggesting that the REHACOP experimental group improved significantly when compared to the control group's performance on both domains.ConclusionsResults suggest that REHACOP is effective to improve executive dysfunction and processing speed deficits in first-episode psychosis and schizophrenia compared to occupational therapy.
P03-125 - Memory Dysfunction and Defective Novelty Detection in Schizophrenia
Authors: Schiltz K. , Zierhut K.C. , Bogerts B. 
Published: June 2010

ObjectivesPatients suffering from schizophrenia display an impairment of memory performance among other cognitive deficits. Long term memory impairment can arise from disturbed encoding and/or retrieval processes subserved by mediotemporal, mesencephalic as well as prefrontal brain regions. We assessed functional and structural integrity of these regions in schizophrenia, specifically during cognitive processes of memory encoding and retrieval.MethodsWe assessed in a set of 3 fMRI studies in a total of 50 schizophrenia patients and an equal number of matched controls whether1)hippocampal/parahippocampal activity during encoding into long term memory is impaired,2)this impairment is related to the memory deficit,3)impaired memory retrieval is associated to mediotemporal/prefrontal dysfunction,4)hippocampal dysfunction is related to symptoms in schizophrenia,5)mesolimbic novelty detection is defective.Functional alterations were related to structural brain changes as detected by voxel-based morphometry.ResultsPatients with schizophrenia displayed a markedly impaired memory performance in our studies. It was related to dysfunction of hippocampal areas during memory encoding as well as novelty detection. During novelty detection, patients had a significantly impaired activity in the mesolimbic loop (hippocampus-ventral tegmental area). Prefrontral and mediotemporal hypofunction was evident during memory retrieval. Positive symptoms were related to a more dysregulated hippocampus activity during memory encoding.ConclusionEvident memory dysfunction in schizophrenia is related to severely altered neuronal processes subserving memory encoding and retrieval which importantly include defective mesolimbic novelty detection. Dysregulated hippocampal activity is related to positive symptoms in schizophrenia and importantly provides a neurobiological link to cognitive deficits.
P03-127 - A Flexible-Dose Study of Paliperidone ER in Non-Acute Patients with Schizophrenia Previously Unsuccessfully Treated with Other Oral Antipsychotics
Authors: Schreiner A. , Hoeben D. , Lahaye M. , Tessier C. , Peuskens J. , Nardini F. , Albrecht W. , Jakovljevic M. , Djukic-Dejanovic S. 
Published: June 2010

ObjectiveTo explore tolerability, safety and treatment response of flexible doses of paliperidone ER in adult non-acute patients with schizophrenia previously unsuccessfully treated with oral antipsychotics.MethodsInternational prospective 6-month open-label study. Endpoints were the Positive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity Scale (CGI-S), patient satisfaction, adverse events (AEs), extrapyramidal symptoms (Extrapyramidal Symptom Rating Scale; ESRS) and weight change.Results1812 patients were included (59.9% male, mean age 40.1±12.6 years, 75.8% paranoid schizophrenia); most were enrolled because of lack of efficacy (n=1026) or lack of tolerability (n=490) with prior antipsychotic treatment. The median mode dose of paliperidone ER was 6 mg/day. 70.7% of patients completed the 6-month study. Most frequent reasons for early discontinuation were patient choice (8.8%), lack of efficacy or adverse event (5.1% each) independent of the reason for switching. Mean total PANSS decreased significantly from 79.4±20.4 at baseline to 66.1±21.5 at endpoint (mean change -13.3±19.7; 95% confidence interval -14.2;-12.3, p< 0.0001). The percentage of patients rated mildly ill or less in CGI-S increased from 27.0% to 52.2% at endpoint, and the rate of patients with mild functional impairment increased from 15.8% to 34.9%. AEs reported in greater-than-or-equal-to 5% of patients were insomnia (9.2%) and anxiety (7.2%). Extrapyramidal symptoms in ESRS decreased significantly from 3.5±5.8 to 2.1±4.6 (p< 0.0001). Mean weight gain from baseline to endpoint was 0.3±4.8kg.ConclusionThese data support results from recent randomized controlled studies that paliperidone ER is safe, well tolerated and effective in patients previously unsuccessfully treated with other oral antipsychotics.