bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANTIHYPERTENSIVE EFFECTIVENESS OF VARIOUS THERAPEUTIC APPROACHES IN RESISTANT HYPERTENSION PATIENTS WITH OR WITHOUT DIABETES MELLITUS: TWO YEARS FOLLOW-UP
Authors: Moiseeva Anna , Caraus Alexandru , Abras Marcel , Ciobanu Nicolae 
Published: May 2024

Objective:
Comparative evaluation of pharmacological treatment with SNS-blockers versus radiofrequency renal denervation on blood pressure values in non-diabetic and diabetic resistant hypertension patients.

Design and method:
Comparative evaluation of pharmacological treatment with SNS-blockers versus radiofrequency renal denervation on blood pressure values in non-diabetic and diabetic resistant hypertension patients.

Results:
A statistically significant reduction in SBP m/24 h was noted in all six groups starting at 6 months, the groups of patients undergoing renal denervation showing superiority over both groups of pharmacological treatment. The progressive improvement continued until the end of the study, so at 2 years of evaluation in observational groups supplemented with Moxonidine the reduction in SBP m/24 h were – 7,28 ± 0,37 mmHg in group I and -7,42 ± 0,36 in group IV mmHg from baseline, in Bisoprolol group – 7,22 ± 0,72 mmHg and – 7,32 ± 0,60 in groups II and V, in renal denervation groups with a total reduction of – 9,76 ± 0,54 mmHg and – 10,0 ± 1,39, p <0,05.
The maximum reduction in DBP m/24 h were registered at 2 years of evaluation, a comparative analyses of dynamics between groups showing a presence of statistical difference due to superiority of renal denervation in amelioration of this parameter.

Conclusions:
All three regimens have been shown to be effective in reducing SBP and DBP m/24 h in treatment of resistant hypertension diabetic and non-diabetic patients, with a comparable effect of Moxonidine and Bisoprolol and the absolute superiority of renal denervation, the beneficial effect being maintained for a period of 2 years.
TEN YEAR FOLLOW-UP OF PATIENTS WITH RESISTANT HYPERTENSION RANDOMIZED TO RENAL DENERVATION OR ANTIHYPERTENSIVE DRUG TREATMENT
Authors: Halvorsen Lene , Larstorp Anne Cecilie K. , Søraas Camilla L. , Hoffmann Pavel , Fossum Eigil , Haig Ylva , Stenehjem Aud E. , Rostrup Morten , Fadl Elmula Fadl Elmula M. , Kjeldsen Sverre E. , Høieggen Aud 
Published: May 2024

Objective:
Renal denervation (RDN) is a treatment option in resistant hypertension. The procedure is considered safe, although randomized trials only demonstrate a moderate blood pressure (BP) lowering effect, when considering medication adherence. Some observational studies describe reduction in BP several years after the procedure. The aim of the study was to describe long-term safety and potential benefits of RDN after ten years, compared to optimized drug treatment, measuring serum concentration of antihypertensive drugs to ensure adherence.

Design and method:
We report data from ten year follow-up of patients randomized to RDN (n=9) or drug adjustment (n=10). Initially the patients had treatment-resistant hypertension, defined as daytime systolic ambulatory BP >= 135 mmHg after witnessed intake (directly observed therapy, DOT) of >= 3 antihypertensive drugs including a diuretic and therefore considered as adherent. One year after RDN or drug adjustment, we optimized antihypertensive medication for all patients. Thereafter, patients received appropriate antihypertensive treatment in primary or secondary care, according to their BPs. Patients were informed of serum concentration measurements performed at the 7-year visit. At the 10-year visit, serum drug measurements before DOT and ambulatory BP measurement (ABPM) were used for evaluation of adherence. Antihypertensive agents were registered, glomerular filtration rate (eGFR) was estimated by the CKD-EPI formula using creatinine and Cystatin C, and renal arteries were examined by CT or MRI.

Results:
All living patients (n=18) attended the 10-year visit, now mean age 69 years, using 4±2 antihypertensive agents, with no difference between groups. Serum concentrations confirmed that all patients were adherent to reported medication. There were significant and similar BP reductions in both groups compared to baseline; daytime ABPM -22±15/9±8 mmHg in the RDN group, and -20±15/13±7 mmHg in the control group (figure). No patients developed renal artery stenosis. The decrease in eGFR was similar in both groups.

Conclusions:
To our knowledge this is the RCT with the longest follow-up supporting long-term safety of RDN in patients with resistant hypertension. Daytime ABPM improved during 10 years of follow-up, not explained by RDN, but due to adjustments in antihypertensive regimens and probably better adherence to medication.
NIGHTTIME BLOOD PRESSURE ASSESSED USING HOME OR AMBULATORY MONITORING IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES/PREDIABETES: RELATIONSHIP WITH PRECLINICAL TARGET-ORGAN DAMAGE
Authors: Ntousopoulos Vasilieos , Kollias Anastasios , Bountzona Ioanna , Destounis Antonios , Menti Ariadni , Theodosiadi Aikaterini , Kyriakoulis Konstantinos , Stergiou George 
Published: May 2024

Objective:
To investigate the relationship between nighttime blood pressure (BP) measurements using home (HBPM) or ambulatory BP monitors (ABPM), with indices of preclinical hypertension mediated organ damage (HMOD) in individuals with hypertension and type 2 diabetes mellitus (DM2) or prediabetes.

Design and method:
Adults with hypertension (treated or untreated) and DM2 or prediabetes underwent 24h ABPM (measurements at 20 minutes intervals, Microlife WatchBP03) and HBPM (duplicate morning/evening measurements for 7 days, 3 nights with 3 measurements/night, Microlife WatchBPHome-N). Participants were also subjected to: (i) echocardiographic measurement of left ventricular mass index (LVMI), (ii) carotid ultrasonography for determination of common carotid intima-media thickness (cIMT) and carotid plaque score, (CPS), (iii) measurement of brachial-ankle pulse wave velocity (PWV; oscillometric device Microlife PWV/ABI), and (iv) measurement of urine albumin-to-creatinine ratio (ACR; two morning urine samples).

Results:
Data from 113 participants were analyzed (mean age [SD] 65±9.1 years, 67% men, body mass index 30.7±4.8 kg/m2, 84% with DM2, 22% cardiovascular disease, 94% treated hypertension). Average daytime HBPM was 129.2±13.2/73.3±7.8 mmHg, and ABPM 126.7±12.1/72.5±7.4 mmHg (systolic/diastolic, p<0.01/p=NS), whilst nighttime HBPM was 115.3±13.1/63.6±7.6 mmHg and ABPM 113.9±13.4/63±7.1 mmHg (systolic/diastolic, p<0.05/p=NS). Nighttime pulse pressure (PP) assessed by both HBPM and ABPM was correlated with LVMI (r=0.25/0.20, respectively, p<0.05 for both), cIMT (r=0.35/0.34, p<0.01), PWV (r=0.21/0.22, p<0.05), CPS (r=0.29/0.26, p<0.01) and ACR (r=0.45/0.38, p<0.01). Z-test for all the above comparisons between HBPM and 24h ABPM was non-significant.

Conclusions:
In individuals with hypertension and DM2 or prediabetes, nighttime BP assessed using a novel home BP monitor is associated with indices of asymptomatic HMOD to a similar degree as reference ABPM.
RELATIONSHIP OF SHORT- AND MID-TERM GLUCOSE VARIABILITY WITH BLOOD PRESSURE PROFILE PARAMETERS IN ADOLESCENTS AND YOUNG ADULTS WITH TYPE 1 DIABETES
Authors: Theodosiadi Aikaterini , Vakali Elena , Kyriakoulis Konstantinos , Destounis Antonios , Vazeou Andriani , Stergiou George , Kollias Anastasios 
Published: May 2024

Objective:
The aim of the study was to investigate the association between blood pressure (BP) profile parameters and short- and mid-term glucose variability (GV) in young individuals with Type 1 Diabetes (T1D).

Design and method:
Individuals aged 12-30 years with T1D underwent simultaneous 24h-ambulatory BP monitoring (ABPM) (20-min intervals, Microlife WatchBP O3) and continuous glucose monitoring for 3 days (day before-during-after ABPM). GV indices [standard deviation (SD), coefficient of variation (CV), mean sensor glucose levels (MSG), mean amplitude of glycemic excursions (MAGE), time in range (TIR)] were assessed for 24h of ABPM, as well as for the 3 days. BP profile parameters (mean values, SD, CV, nighttime BP dip) were also evaluated.

Results:
61 individuals were analyzed [34 males (56%), 35 (58%) on insulin pump therapy, mean age 22±5.6 years, BMI 23±4 kg/m2, HbA1c 7.1±1.0%, T1D duration 11±6.6 years, 24h ABPM 111±8.4/67±5.4 mmHg (systolic/diastolic), 24h ambulatory hypertension 4.9%]. Nighttime BP dip was inversely correlated with 24h nighttime MAGE (r=-0.30/-0.26 systolic/diastolic, p<0.04), whereas nighttime pulse pressure (PP) was inversely correlated to 24h TIR (r=-0.25, p=0.05). 24h daytime MAGE demonstrated inverse associations with SD and CV of daytime HR (r=-0.26/-0.26, p=0.04). A trend was observed between 24h nighttime MAGE and SD and CV of nighttime systolic BP (r=-0.20/-0.23, p=0.1/0.08 respectively). Furthermore, T1D duration was correlated with nighttime HR (r=0.26, p=0.04) and SD of nighttime diastolic BP (r=0.29, p=0.03). When GV indices derived from the 3-day period were examined, nighttime systolic BP correlated with 3-day MAGE (r=0.25, p=0.05) and inversely with 3-day TIR (r=-0.28, p=0.03). Lastly, daytime systolic BP was associated with 3-day daytime MAGE (r=0.28, p=0.03) and 24h systolic BP with 3-day SD of glucose (r=0.28, p=0.03) and 3-day MAGE (r=0.27, p=0.03).

Conclusions:
These data suggest that in young individuals with T1D there is a relationship between GV and BP parameters. The average BP levels, as well as nocturnal BP dip, were associated with several indices of GV, implying a potential common pathophysiologic background.
BLOOD PRESSURE AND GLUCOSE VARIABILITY IN ADOLESCENTS AND YOUNG ADULTS WITH TYPE 1 DIABETES: ASSOCIATION WITH PRECLINICAL TARGET-ORGAN DAMAGE
Authors: Theodosiadi Aikaterini , Vakali Elena , Kyriakoulis Konstantinos , Destounis Antonios , Vazeou Andriani , Stergiou George , Kollias Anastasios 
Published: May 2024

Objective:
To investigate the relationship between blood pressure (BP) and glucose variability with indices of preclinical target-organ damage in adolescents and young adults with type 1 diabetes (T1D).

Design and method:
Individuals aged 12-30 years with T1D underwent simultaneous 24h-ambulatory BP monitoring (ABPM) (20-min intervals, Microlife WatchBP O3) and continuous glucose monitoring for 3 days (day before-during-after the ABPM), as well as assessment of indices of preclinical target-organ damage [left ventricular mass index (LVMI), intima-media thickness of common carotid artery (IMT), albumin-to-creatinine ratio (ACR) in two different morning urine samples]. Glucose variability indices [standard deviation (SD), coefficient of variation (CV), mean sensor glucose levels (MSG), mean amplitude of glycemic excursions (MAGE), time in range (TIR)] were calculated. BP profile parameters (mean values, SD, CV, nighttime BP dip) were also evaluated.

Results:
Data from 61 individuals were analyzed [34 males (56%), 35 individuals (58%) on insulin pump therapy, mean age 22±5.6 years, BMI 23±4 kg/m2, HbA1c 7.1±1.0%, T1D duration 11±6.6 years, 24h ABPM 111±8.4/67±5.4 mmHg (systolic/diastolic), 24h ambulatory hypertension 4.9%]. Nighttime systolic BP was correlated with both LVMI and IMT (r=0.33/0.47, respectively, p<0.02). BP variability indices were not correlated with target-organ damage. IMT was inversely correlated with the 3-day TIR (r=-0.34, p<0.02) and positively with 3-day MSG (r=0.33, p=0.01), 3-day MAGE (r=0.29, p=0.03), 3-day SD of glucose (r=0.28, p=0.03), and T1D duration (r=0.27, p=0.04). LVMI was inversely associated with daytime TIR on the ABPM day (r=-0.34, p=0.02). Participants with ACR at the upper quartile of the distribution (>=7.5 mg/g) showed an association between nighttime systolic BP and ACR (r=0.58, p=0.02). Lastly, there was a trend towards an association between ACR and HbA1c (r=0.54, p=0.06).

Conclusions:
These findings suggest that among mainly normotensive young individuals with T1D, increased BP level and glycemic variability are associated with early target organ damage.
INSULIN RESISTANCE, CAROTID INTIMA-MEDIA THICKNESS, BODY MASS INDEX IN PATIENTS WITH CORONARY ARTERY DISEASE COMBINED WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE
Authors: Grechanyk Mariya , Kuryata Olexander 
Published: May 2024

Objective:
To compare the relationship systolic and diastolic blood pressure (BP) with insulin resistance (IR), carotid intima-media thickness and body mass index (BMI) in patients with coronary artery disease (CHD) combined with metabolic dysfunction-associated steatotic liver disease (MASLD).

Design and method:
We studied 78 patients with CHD in combination with MASLD mean age 58,8±2,14 (group A) and 20 patients with CHD without MASLD mean age 56,6±4,6 (group B). Patients with diabetes were excluded. The study group was divided into 3 subgroups according to BMI (subgroup 1 (36%) - patients who are overweight, 2 (39%) - obesity grade 1, 3 (25%) - obesity grade 2. Studied IR, carotid intima-media thickness depending on BMI.

Results:
In group A the mean level systolic BP and diastolic BP was higher than in group B (140 [130,0; 160,0], 132,5 [120,0; 150,0], p =0,02 and 90 [85,0; 100,0], 80,0 [75,0; 90,0], p=0,001) 82% of patients with CAD and MASLD had insulin resistance (IR). HOMA1-IR index in patients with 2 class obesity was 3.4 compared to the group of patients with 1 class obesity – 2.35 and overweight patients – 2.26, respectively (p<0.05). Carotid wall thickness was lower in a group A (0,14±0,02 cm) than in a group B (0,16±0,01 cm, p =0,01). Frequency of exposure of atherosclerotic carotid plaques in a group A – 82%, was higher than in a group B – 64% (p <0,05). In group A unstable plaques found significantly more often (31%, p = 0,01), than in the control group B (8%).

Conclusions:
There was an association between the BMI and level of glucose (r=0,59, p<0,05) in patients with CHD in combination with MASLD. According to HOMA1-IR index IR was detected in 7% of the overweight patients, in 22% patients with 1 class obesity and in 62% with 2 class; and 86%, 72% and 84% according to the HOMA2-IR index, respectively (p<0.05). According to the frequency of unstable carotid plaques, no statistically significant differences were found between groups depending on BMI.
COMPARISON OF LEFT VENTRICULAR VOLUMES AND EJECTION FRACTION VALUES BETWEEN ECHOCARDIOGRAPHY AND CARDIAC MAGNETIC RESONANCE: A PILOT STUDY
Authors: Zydzik Lukasz , Dadanski Emil , Tyjas Kinga , Wojciechowska Wiktoria , Chyrchel Bernadeta , Popiela Tadeusz , Rajzer Marek 
Published: May 2024

Objective:
Although transthoracic echocardiography (TTE) is the most commonly used technique to evaluate left ventricular (LV) parameters, cardiac magnetic resonance (CMR) is considered to provide more accurate measurements. The aim of this study was to compare LV end-diastolic volume (LVEDV), end-systolic volume (LVESV) and ejection fraction (LVEF) assessed by TTE with those parameters obtained by CMR.

Design and method:
The study included 100 patients who underwent both TTE and CMR between 2021 and 2023. Echocardiographic images were analysed retrospectively by three independent investigators (R1, R2, R3). The following parameters were obtained using Simpson's biplane method: LVEDV, LVESV and LVEF. The echocardiographic values assessed by each investigator were then compared with reference values obtained by CMR. Statistical analyses were performed using repeated measures ANOVA with post hoc pairwise t-tests with Bonferroni correction.

Results:
The mean age of the study population was 47±18 years, 64% were male, and the median time between TTE and CMR was 27 days. The most common indication for CMR was evaluation of suspected cardiomyopathy (42%), followed by suspected acute myocarditis (16%). The repeated measures ANOVA test showed that there was a significant difference between measurements (R1/R2/R3/CMR) of LVEDV (R1=132.47 ml, R2=132.38 ml, R3=122.69 ml, CMR=183.72 ml, p=0.002) and LVESV (R1=59.27 ml, R2=65.7 ml, R3=60.97 ml, CMR=80.23 ml, p=0.002). Post hoc analysis showed that the differences were only due to the discrepancy between each echocardiographer and magnetic resonance imaging. There was no significant difference in LVEF between measurements (R1=44.44%, R2=47.56%, R3=46.96%, CMR=48.5%, p=0.243).

Conclusions:
Our study shows that echocardiographic values of LV volumes and EF have low interobserver variability. TTE tends to underestimate LV volumes compared to CMR, but LVEF is similar with both techniques.
SIMPLIFID LUNG ULTRASOUND IN DIAGNOSIS OF HEART FAILURE WITH PRESERVED EJECTION FRACTION IN ARTERIAL HYPERTENSION
Authors: Tsverava Mikheil , Tsverava Dimitri 
Published: May 2024

Objective:
About 30% of patients with heart failure (HF) have normal Ejection Fraction (HFpEF). Pulmonary congestion is useful marker of HFpEF. The aim of this study was to determine the efficacy of ultrasound in patients with DHF.

Design and method:
We studied 250 patients with Arterial Hypertension and III-IV NYHA class HF from which 70 patients had HFpEF (group 1) and 100 patients Left Ventricular Diastolic Dysfunction but without signs of HF (control, group 2). All participants undergone standard Echo Cardiography. Sonographic evaluation of a lung was done in horizontal or vertical positions of patient, from 10 points of thoracic wall (5 points from each side), which corresponded to the projection of lower, middle and upper lobes of a right lung and upper and lower lobes of left lung.

Results:
In patients with HFpEF we significantly often found multiple (3 or more) B-lines or Comet tail Phenomenon (CTPh), which was registered in 91.1%. In 40.0% of control group patients, we also registered B-lines, but the count of them was less than 3 lines per each registration point (the difference between control an HF groups was significant). The count of points from where the CTPh was registered was 6.8 in HFpEF gr. and 0.7 in control.
The B-lines were registered from 3 or more points of thoracic wall in 82.86% of patients of I gr and only 5% in II gr participants. In HF groups CTPh was prominent and multiple while in the control group it was single and short lasting, like lightening. There was good correlation between the count of B-line registration points from the thoracic wall and the heart failure NYHA class (r=0.56), left ventricular systolic (r=0.40) and diastolic (r=0.32) diameters and negative MAPS and TAPS (r=-0.42 and 0.41 respectively).

Conclusions:
Thoracic US is a sensitive and accurate method for evaluation pulmonary congestion in patients with AH and HFpEF. The US sign of pulmonary congestion in HF are B-lines or Comet tail phenomenon, which is protracted, prominent, multiple and registered from larger area of thoracic wall (3 points or more).
TREADMILL EXERCISE TEST AND DEVELOPMENT OF HYPERTENSION
Authors: Kalos Theodoros , Dimitriadis Kyriakos , Manta Eleni , Leontsinis Ioannis , Drogkaris Sotirios , Tatakis Fotios , Konstantinidis Dimitrios , Christos Fragkoulis , Liatakis Ioannis , Matzouranis Emmanouil , Sakalidis Athanasios , Andrikou Ioannis , Kakouri Androniki , Kouremeti Maria , Tsioufis Konstantinos 
Published: May 2024

Objective:
Guidelines promote screening people with high normal BP for the presence of end-organ damage because their presence is associated with a 2- to 3-fold increase in the risk of CVD.

Design and method:
100 consecutive subjects with high normal BP [systolic BP=130-139mmHg and/or diastolic BP=85-89mmHg] were examined for early signs of hypertension-mediated organ damage (HMOD). They underwent an echocardiographic study, a negative for ischemia treadmill exercise test (Bruce protocol) where the index SBP/MET-slope [(peakSBP—restingSBP)/(peakMET-1)] was used. Arterial stiffness was evaluated based on carotid-femoral pulse wave velocity (PWV). The sympathetic drive was assessed by MSNA. Follow-up was scheduled every 6 months for 3 consecutive years, where BP measurements were assessed in the office and with ambulatory BP monitoring (ABPM). All participants offered lifestyle advice to lower their BP. The endpoint was the development of HTN either with Office BP or ABPM.

Results:
Of 100 subjects (54±8 years, 42 males, baseline office BP: 132/82 mmHg, 24-hour BP: 122/76 mmHg) 40 developed HTN in 3 years. 34 subjects developed Hypertensive Response to Exercise (HRE) (BP >210mmHg in men and >190mmHg in women) and all of them developed HTN. The SBP/MET-slope in Group I was increased in all stages till peak exercise independently of sex type (stage1: 6.7vs4.9 p=0.049, stage2: 8.4vs4.8 p=0.001, peak: 6.7vs4.9, p=0.001). Their exercise capacity was reduced (10vs11.3METs, p=0.002) as well as their maximum exercise heart rate (156vs164, p=<0.0001). Those with HRE had higher 24hSBP (124vs121mmHg, p=0.009), Night SBP (117vs111mmHg, p<0.001), Day SBP (127vs124mmHg, p=0.012) Office PP (51vs47mmHg, p=0.01), while did not differ regarding their metabolic profile at the follow-up. Additionally, they had increased PWV (8.3vs7.5m/sec, p=<0.0001), MSNA levels (36vs28 bursts, p=<0.0001), LVMI(38vs34 gr/m2, p=0.02), deteriorated 2021 CKD-EPI eGFR (90 vs 97 mL/min/1.73 m2, p=0.02).

Conclusions:
Detecting exaggerated blood pressure response is associated with increased systemic vascular resistance and early subclinical HMOD which may upgrade an individual's cardiovascular disease (CVD) risk as they progress to HTN indicating a need for instituting a BP-lowering strategy.
POSSIBILITIES OF THE METHOD OF VOLUMETRIC COMPRESSIVE OSCILLOMETRY FOR THE ASSESSMENT OF BLOOD PRESSURE AND ARTERIAL STIFFNESS IN PATIENTS WITH DECOMPENSATED HEART FAILURE
Authors: Chudarova Irina , Troitskaya Elena , Kozlova Anna , Andreeva Ekaterina , Galochkin Svyatoslav , Tereshchenko Ekaterina , Kobalava Zhanna 
Published: May 2024

Objective:
Volumetric compressive oscillometry (VCO) is a technique for non-invasive simultaneous assessment of >20 hemodynamic parameters, including arterial stiffness (AS) by pulse wave velocity (PWV). The possibilities of the method in heart failure (HF) had never been studied previously. The aim of the study was to evaluate the concordance of the results of BP and AS measurement by VCO in patients admitted with decompensated HF by comparing them to standard BP measurement and applanation tonometry (AT).

Design and method:
In patients admitted to the HF center with decompensated HF apart from routine tests, we assessed PWV (carotid-femoral (cf), carotid-radial (cr)) with AT (SphygmoCor) and performed VCO (APKO-8-RIZ-M) (BPvco, PP vco and PWVvco were evaluated). The concordance of the results was assessed by Bland-Altman method. p<0,05 was considered statistically significant.

Results:
We included 54 patients (61% males, 69.6±10 years, median (med) BMI 28.8 (IQR 25;38.9) kg/m2, 38.9% smokers, HTN in all, DM 37%, CAD 51.9%, med EF 51% (38;55%), med NTproBNP 623 (500;1842) pg/ml; HFrEF 37%, HFmrEF 13%, HFpEF 50%). Median BP was 117(106;130)/70 (68;80) mmHg, pulse pressure (PP) 47 (37;56) mmHg, central BP 109.5 (96;120.5)/71.5 (68;80) mmHg, med cfPWV 8 (6.4;10) m/s, crPWV 9.5 (6.9;12.4) m/s. Median BP by VCO 110 (101;118.5)/56 (47;65) mmHg, PP by VCO was 52.7 (46.3;60) mmHg, median PWV was 6.2 (5.5;7.1). There were no significant differences across EF phenotypes. Bland-Altman method showed no concordance between office brachial BP and BPvco (mean difference 9.3 (95%CI 4.8;13.8) mmHg for SBP and 16.8 (95%CI 13.8;19.8) mmHg for DBP, p<0.001 for trend), brachial PP and PPvco (mean difference -6.5 (95%CI -10.2;-2.9) mmHg, p=0.001) and cfPWV or crPWV by AT and PWV by VCO (mean difference 4.2 (95%CI 2.9;5.5) m/s and 2.7 (95%CI 1.4;4.1) m/s, respectively, p<0.001 for trend).

Conclusions:
In patients with decompensated HF VCO can‘t be used as an alternative standard BP measurement and assessment of arterial stiffness by applanation tonometry.