bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: Results of a randomized, double‐blind, placebo‐controlled trial
Authors: Arnold Lesley M. , Gendreau R. Michael , Palmer Robert H. , Gendreau Judy F. , Wang Yong 
Published: May 2010

AbstractObjectiveTo assess the efficacy and safety of milnacipran at a dosage of 100 mg/day (50 mg twice daily) for monotherapy treatment of fibromyalgia.MethodsA double‐blind, placebo‐controlled trial was performed to assess 1,025 patients with fibromyalgia who were randomized to receive milnacipran 100 mg/day (n = 516) or placebo (n = 509). Patients underwent 4–6 weeks of flexible dose escalation followed by 12 weeks of stable‐dose treatment. Two composite responder definitions were used as primary end points to classify the response to treatment. The 2‐measure composite response required achievement of ≥30% improvement from baseline in the pain score and a rating of “very much improved” or “much improved” on the Patient's Global Impression of Change (PGIC) scale. The 3‐measure composite response required satisfaction of these same 2 improvement criteria for pain and global status as well as improvement in physical function on the Short Form 36 (SF‐36) physical component summary (PCS) score.ResultsAfter 12 weeks of stable‐dose treatment, a significantly greater proportion of milnacipran‐treated patients compared with placebo‐treated patients showed clinically meaningful improvements, as evidenced by the proportion of patients meeting the 2‐measure composite responder criteria (P < 0.001 in the baseline observation carried forward [BOCF] analysis) and 3‐measure composite responder criteria (P < 0.001 in the BOCF). Milnacipran‐treated patients also demonstrated significantly greater improvements from baseline on multiple secondary outcomes, including 24‐hour and weekly recall pain score, PGIC score, SF‐36 PCS and mental component summary scores, average pain severity score on the Brief Pain Inventory, Fibromyalgia Impact Questionnaire total score (all P < 0.001 versus placebo), and Multidimensional Fatigue Inventory total score (P = 0.036 versus placebo). Milnacipran was well tolerated by most patients, with nausea being the most commonly reported adverse event (placebo‐adjusted rate of 15.8%).ConclusionMilnacipran administered at a dosage of 100 mg/day improved pain, global status, fatigue, and physical and mental function in patients with fibromyalgia.
Interferon‐γ–dependent inhibition of B cell activation by bone marrow–derived mesenchymal stem cells in a murine model of systemic lupus erythematosus
Authors: Schena Francesca , Gambini Claudio , Gregorio Andrea , Mosconi Manuela , Reverberi Daniele , Gattorno Marco , Casazza Simona , Uccelli Antonio , Moretta Lorenzo , Martini Alberto , Traggiai Elisabetta 
Published: May 2010

AbstractObjectiveBone marrow–derived mesenchymal stem cells (BM‐MSCs) are multipotent cells characterized by immunomodulatory properties and are therefore considered a promising tool for the treatment of immune‐mediated diseases. This study was undertaken to assess the influence of murine BM‐MSCs on the activation of B cells in (NZB × NZW)F1 mice as an animal model of systemic lupus erythematosus (SLE).MethodsWe evaluated the in vitro effects of BM‐MSCs on the proliferation and differentiation to plasma cells of splenic mature B cell subsets, namely follicular and marginal zone B cells isolated from (NZB × NZW)F1 mice. Lupus mice were also treated with BM‐MSCs, and serum autoantibodies, proteinuria, histologic changes in the kidney, and survival rates were monitored.ResultsBM‐MSCs inhibited antigen‐dependent proliferation and differentiation to plasma cells of follicular and marginal zone B cells in vitro. This inhibitory effect was dependent on interferon‐γ (IFNγ) and was mediated by cell‐to‐cell contact, involving the programmed death 1 (PD‐1)/PD ligand pathway. In vivo treatment with BM‐MSCs did not affect the levels of anti–double‐stranded DNA antibodies or proteinuria. However, a reduction in glomerular immune complex deposition, lymphocytic infiltration, and glomerular proliferation was observed.ConclusionOur findings indicate that BM‐MSCs affect B cell receptor–dependent activation of both follicular and marginal zone B cells from lupus mice. This inhibitory effect is IFNγ‐dependent and cell contact–dependent. MSCs in vivo do not affect the production of autoantibodies, the level of proteinuria, or the mortality rates. Nonetheless, the significant improvement in histologic findings in the kidney supports the potential role of MSCs in the prevention of glomerular damage.
Hydrogen Production by Water Dissociation in Surface‐Modified BaCoxFeyZr1−x−yO3−δ Hollow‐Fiber Membrane Reactor with Improved Oxygen Permeation
Authors: Jiang Heqing , Liang Fangyi , Czuprat Oliver , Efimov Konstantin , Feldhoff Armin , Schirrmeister Steffen , Schiestel Thomas , Wang Haihui , Caro Jürgen 
Published: May 2010

AbstractA porous perovskite BaCoxFeyZr0.9−x−yPd0.1O3−δ (BCFZ‐Pd) coating was deposited onto the outer surface of a BaCoxFeyZr1−x−yO3−δ (BCFZ) perovskite hollow‐fiber membrane. The surface morphology of the modified BCFZ fiber was characterized by scanning electron microscopy (SEM), indicating the formation of a BCFZ‐Pd porous layer on the outer surface of a dense BCFZ hollow‐fiber membrane. The oxygen permeation flux of the BCFZ membrane with a BCFZ‐Pd porous layer increased 3.5 times more than that of the blank BCFZ membrane when feeding reactive CH4 onto the permeation side of the membrane. The blank BCFZ membrane and surface‐modified BCFZ membrane were used as reactors to shift the equilibrium of thermal water dissociation for hydrogen production because they allow the selective removal of the produced oxygen from the water dissociation system. It was found that the hydrogen production rate increased from 0.7 to 2.1 mL H2 min−1 cm−2 at 950 °C after depositing a BCFZ‐Pd porous layer onto the BCFZ membrane.
PAMAM Dendrimers for siRNA Delivery: Computational and Experimental Insights
Authors: Pavan Giovanni Maria , Posocco Paola , Tagliabue Aaron , Maly Marek , Malek Anastasia , Danani Andrea , Ragg Enzio , Catapano Carlo V. , Pricl Sabrina 
Published: May 2010

AbstractShort double‐stranded RNAs, which are known as short interfering RNA (siRNA), can be used to specifically down‐regulate the expression of the targeted gene in a process known as RNA interference (RNAi). However, the success of gene silencing applications based on the use of synthetic siRNA critically depends on efficient intracellular delivery. Polycationic branched macromolecules such as poly(amidoamine) (PAMAM) dendrimers show a strong binding affinity for RNA molecules and, hence, can provide an effective, reproducible, and relatively nontoxic method for transferring siRNAs into animal cells. Notwithstanding these perspectives, relatively few attempts have been made so far along these lines to study in detail the molecular mechanisms underlying the complexation process between PAMAMs and siRNAs. In this work we combine molecular simulation and experimental approaches to study the molecular requirements of the interaction of RNA‐based therapeutics and PAMAM dendrimers of different generations. The dendrimers and their siRNA complexes were structurally characterized, and the free energy of binding between each dendrimer and a model siRNA was quantified by using the well‐known MM/PBSA approach. DOSY NMR experiments confirmed the structural in silico prediction and yielded further information on both the complex structure and stoichiometry at low N/P ratio values. siRNA/PAMAM complex formation was monitored at different N/P ratios using gel retardation assays, and a simple model was proposed, which related the amount of siRNA complexed to the entropy variation upon complex formation obtained from the computer simulations.
ChemInform Abstract: Chemical Segregation During Bulk Single Crystal Preparation of Ni—Mn—Ga Ferromagnetic Shape Memory Alloys.
Authors: Schlagel D. L. , Wu Y. L. , Zhang W. , Lograsso T. A. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reactions of Aluminum, Gallium, and Indium (M) Atoms with Phosphine: Generation and Characterization of the Species M×PH3, HMPH2, and H2MPH.
Authors: Himmel Hans‐Joerg , Downs Anthony J. , Greene Tim M. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Asymmetric Aziridination with Arylborate Catalysts Derived from VAPOL and VANOL Ligands.
Authors: Antilla Jon C. , Wulff William D. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Planar‐Chiral Pyridine N‐Oxides, a New Family of Asymmetric Catalysts: Exploiting an η5‐C5Ar5 Ligand to Achieve High Enantioselectivity.
Authors: Tao Beata , Lo Michael M.‐C. , Fu Gregory C. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photochemistry of 4H,7H‐Benzo[1,2‐c:4,3‐c′]dipyran‐4,7‐dione, a Twofold Isocoumarin
Authors: Kinder Michael A. , Margaretha Paul 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thermal Cyclization of (2‐Ethynylphenyl)triazenes: Facile Synthesis of Substituted Cinnolines and Isoindazoles.
Authors: Kimball David B. , Hayes Austin G. , Haley Michael M. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Selective Catalytic Intermolecular Reductive Coupling of Alkynes and Aldehydes.
Authors: Huang Wei‐Sheng , Chan Johann , Jamison Timothy F. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: cis‐4,4,6‐Trimethylbicyclo[3.1.1]heptan‐2‐one in the Synthesis of Nitrogen‐Containing Bicyclic Compounds.
Authors: Koval'skaya S. S. , Kozlov N. G. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of New Anti‐Tubulin Ligands Through a Dual‐Mode, Addition—Elimination Reaction to a Bromo‐Substituted α,β‐Unsaturated Sulfoxide.
Authors: Chen Zhi , Mocharla Vani P. , Farmer J. Matt , Pettit George R. , Hamel Ernest , Pinney Kevin G. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient One‐Pot Synthesis of Polysubstituted Pyrroles.
Authors: Katritzky Alan R. , Huang Tian‐Bao , Voronkov Michael V. , Wang Mingyi , Kolb Hartmuth 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective 1,3‐Dipolar Cycloaddition Reactions of Unsymmetrical Muenchnones (1,3‐Oxazolium‐5‐olates) with 2‐ and 3‐Nitroindoles. A New Synthesis of Pyrrolo[3,4‐b]indoles.
Authors: Gribble Gordon W. , Pelkey Erin T. , Simon Wendy M. , Trujillo Hernando A. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Regioselective Synthesis of Decahydrobenzocarbazoles Using Rhodium‐Generated Carbonyl Ylides with Indoles.
Authors: Muthusamy Sengodagounder , Gunanathan Chidambaram , Babu Srinivasarao Arulananda 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Synthesis of 4‐((N‐(tert‐Butoxycarbonyl)amino)methyl)‐7‐N‐ (tert‐butoxycarbonyl)‐3‐oxa‐2,7‐diazabicyclo[3.3.0]oct‐1‐ene.
Authors: Kang Ho‐Jung 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Thiazolinyl, Thiazolidinonyl, Thiadiazolyl and Oxadiazolyl‐benzotriazole Derivatives with Potential Antiinflammatory Activity and Minimum Ulcerogenic Effect.
Authors: Habib N. S. , Fahmy S. , El‐Khawass S. M. , Aziem T. Abdel 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Method for the Preparation of 2,3‐Cycloalkeno‐5,6‐cycloalkeno‐4H‐pyran‐4‐ones.
Authors: Xu Fan , Cao Xueqin , Cao Zhengbai , Zou Lei 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Practical and Large‐Scale Synthesis of rac‐(3S,4aR,10aR) ‐6‐Methoxy‐1‐propyl‐1,2,3,4,4a,5,10,10a‐octahydrobenzo [g]quinoline‐3‐carboxylic Acid Methyl Ester.
Authors: Baenziger Markus , Cercus Jacques , Stampfer Wolfgang , Sunay Ustun 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthesis of N‐Benzyl‐3‐sulfonyl Glutarimides. Formal Synthesis of the Aromatase Inhibitor AG‐1.
Authors: Chang Meng‐Yang , Chang Bo‐Rui , Tai Huo‐Mu , Chang Nein‐Chen 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antibacterial Activity of New Sulfonamides of Pyrimidine.
Authors: Cieplik Jerzy , Pluta Janusz , Gubrynowicz Olaf 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Pressure Synthesis of Enantiomerically Pure C‐6 Substituted Pyrazolo[3,4‐d]pyrimidines.
Authors: Poulsen Sally‐Ann , Young David J. , Quinn Ronald J. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclopropyl Building Blocks for Organic Synthesis. Part 64. Facile Preparation of Hexahydropyrrolo[3,2‐e][1,4]diazepine‐2,5‐diones and Tetrahydrofuro[1H][3,2‐e][1,4]diazepine‐2,5‐diones by Rearrangements of Cyclopropylketimines and Cyclopropylketones.
Authors: Funke Christian , Es‐Sayed Mazen , de Meijere Armin 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: First Synthesis of Dioxadithiaporphycene with a Benzene Ring Fused onto the Double Bond.
Authors: Dai Wei‐Min , Mak Wing Leung 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoreaction of o‐Acylstyrenes: Formation of Benzo‐Fused 8‐Oxabicyclo[3.2.1]octanes.
Authors: Oda Kazuaki , Nakagami Rikiji , Nishizono Naozumi , Machida Minoru 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogenation of Silyl‐Substituted Alkynes Using Diimide: Application to the Synthesis of Saturated Sila‐Macrocycles.
Authors: Kwon Eunsang , Sakamoto Kenkichi , Kabuto Chizuko , Kira Mitsuo 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New One‐Pot Synthesis of Alkynylphosphonates.
Authors: Lera Manuel , Hayes Christopher J. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring Closing Metathesis of a 4,6‐Diallyl‐myo‐inositol Orthoformate as a Model for an Inositol Cyclopolymer.
Authors: Kim Tae‐Hyun , Giles Mark , Holmes Andrew B. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of Highly Functionalized C‐Glycosides Based on Acetal [1,2] and [1,4] Wittig Rearrangements.
Authors: Tomooka Katsuhiko , Yamamoto Hiroshi , Nakai Takeshi 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of a Hybrid Fullerene—Trimethoxyindole—Oligonucleotide Conjugate.
Authors: Bergamin Massimo , Da Ros Tatiana , Spalluto Giampiero , Boutorine Alexandre , Prato Maurizio 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Total Synthesis of Rhizoxin D.
Authors: Keck Gary E. , Wager Carrie A. , Wager Travis T. , Savin Kenneth A. , Covel Jonathan A. , McLaws Mark D. , Krishnamurthy Dhileep , Cee Victor J. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Blasticidin A as an Inhibitor of Aflatoxin Production by Aspergillus parasiticus
Authors: Sakuda Shohei , Ono Makoto , Ikeda Hiroyuki , Nakamura Takefumi , Inagaki Yasuhito , Kawachi Ryu , Nakayama Jiro , Suzuki Akinori , Isogai Akira , Nagasawa Hiromichi 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the C11—C21 and C13—C21 Fragments of Epothilones from D‐Glucose.
Authors: Lee Hyo Won , Lee Ihl‐Young Choi , Hong Yong Deog 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.