bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategies to Combat Resistance to Anti-angiogenesis Therapies in Cancer: Current Status and Future Prospects
Authors: Patel Vijay K. , Shirbhate Ekta , Singh Vaibhav , Parveen Shadiya , Veerasamy Ravichandran , Tiwari Amit K. , Rajak Harish 
Published: February 2025

Abstract:
Anti-angiogenic therapy represents a promising approach to cancer treatment by targeting
the vascular support systems of tumors rather than the tumor cells themselves. Antiangiogenic
agents face numerous obstacles that impede their efficacy, notwithstanding their potential: mechanistic
complexity, toxicity, resistance, and the lack of validated predictive biomarkers. Resistance
mechanisms may encompass genetic modifications, alternative angiogenic pathways, or the recruitment
of cells derived from bone marrow. This work examines present problems and approaches
to overcome resistance against anti-angiogenic treatment. Treatment response is predicted by
biomarker-guided therapy; patterns of circulating endothelial cells, IL-8 levels, and VEGFR expression
indicate possible therapeutic monitoring value. Multi-targeted approaches including drugs
that block VEGFR, PDGFR, FGFR, and c-MET concurrently have shown more efficacy than single-
pathway inhibition. Additional research indicates that combining treatments has positive results.
Combining anti-angiogenic agents with cancer vaccines increases immune responses and
tumour regulation. Combining radiotherapy with chemotherapy increases drug delivery and efficacy
utilizing vascular normalisation. Techniques based on nanotechnology such as gold nanoparticles
and carbon-based materials may enhance medicinal efficacy and delivery. These results reveal
that to overcome resistance mechanisms and enhance patient outcomes anti-angiogenic therapy
must combine focused therapies with precision medicine approaches.
Antioxidant Activities and Phenolic Profile of Chamomile (Matricaria recutita): A Herbal Tea from Pakistan
Authors: Sabir Syed Mubashar , Shahida Shabnam , Iqbal Wizra , Zeb Alam , Khan Muhammad Imran , Shanableh Abdallah , Khan Asma , Ghernaout Djamel , Elboughdiri Noureddine 
Published: February 2025

Abstract:
The present study aimed to determine the antioxidant potential and phytochemical components
of aqueous extract of Matricaria recutita, which grows in hilly areas of Azad Kashmir, Pakistan.
In order to evaluate its antioxidant activity, different methods, such as DPPH radical scavenging,
ABTS scavenging, lipid peroxidation, and metal chelation assays, were performed. The flower
extract showed higher DPPH radical scavenging activity (IC50: 75.3 μg/ml) compared to the leaf
extract (IC50: 82.3 μg/ml). Similarly, the flower extract displayed higher ABTS radical scavenging
activity (IC50: 102.3 μg/ml) compared to the leaf extract (IC50: 107.5 μg/ml). Significant metal chelating
ability was observed of Matricaria recutita. There existed a significant correlation among the
different antioxidant activities. Detailed phytochemical analysis of flower extracts showed the presence
of important phenolic and flavonoid compounds, including gallic acid, chlorogenic acid, caffeic
acid, qurecetin-3-galactoside, apigenin-7-glucoside, kaempferol-3-sinapoylsophotrioside, esculetin,
kaempferol 3-(caffeoyldiglucoside)-7-rhamnoside, quercetin-3-sinapolysophoroside-7-glucoside,
quercetin-3-(caffeoyl-diglucoside)-7-glucoside, isorhamnetin-3-(caffeoyldiglucoside)-7-rhamnoside,
kaempferol-3-feruloylsophoroside-7-glucoside, kaempferol-3-malonylglucoside, quercetin-3-(6″-
acetyl)glucosyl-2″-sinapic acid, 5, 7, 3′-trihydroxy-6, 4′, 5′-trimethoxyflavone, and tetrahydroxydimethoxyflavone.
On the basis of these results, it has been concluded that Matricaria recutita collected
from Azad Kashmir contains important phytochemicals and can be utilized as a source of antioxidants.
Exploring Neighborhood Topological Descriptors for Quantitative Structure-property Relationship (QSPR) Analysis and Entropy Measures of Some Anti-cancer Drugs
Authors: Augustine Tony , Santiago Roy , Jeyaraj Sahaya Vijay , Azeem Mohamad 
Published: February 2025

Background:
This study investigated many cancer medicines using a wide range of degree sum-based topological indices and entropy. These numerical numbers, commonly referred to as topological indices or molecular descriptors, depict a substance’s molecular structure. They have been successfully used to properly reflect different physicochemical properties in a number of Quantitative Structure-Property Relationship (QSPR) and Quanti-tative Structure-Activity Relationship (QSAR) research studies.

Objective:
The purpose of the study was to investigate the relationships between topological neighborhood indices and physicochemical properties using the QSPR model and linear re-gression methodology.

Methods:
We employed linear regression methodology within the QSPR model to examine the connections between physicochemical characteristics and topological neighborhood in-dices.

Results:
The results revealed a significant correlation between the neighborhood indices un-der scrutiny and the physicochemical features of the potential drugs under investigation.

Conclusion:
As a result, both neighborhood topological indices and entropy demonstrate potential as valuable tools for future QSPR investigations when evaluating anticancer medi-cations.
Lavandula Species as a Bioactive Phytomolecule and Medicinal Properties: A Review
Authors: Srivastava Kajal , Yadav Chandra Shakher , Azad Iqbal , Srivastava Manjoosha , Niranjan Abhishek , Khan Abdul Rahman , Pal Mahesh 
Published: February 2025

Abstract:
The family Lamiaceae includes the genus Lavandula, which is widely cultivated
throughout the Mediterranean region, including France, Spain, and Italy. The plant forms dense
clumps that are roughly 40-60 cm tall. The reference genome for "Jingxun 2," an excellent cultivar
of Lavender (Lavandula angustifolia) was created by a research team in China. Lavandula
which contains tannins, phytosterols, coumarins, herniarins, ursolic acid, sugars, valeric acid, glycolic
acid, coumaric acid, anthocyanins, minerals, and essential oils. Lavender oil can also help
with many kinds of health problems because it has many bioactive ingredients, such as linalool,
lavandulol, anthocyanins, geraniol, ursolic acids, linalyl acetate, valeric acid, 1,8-cineole, borneol,
lavandulyl acetate, terpinen-4-ol, camphor, phytosterols, coumaric acid, and glycolic acid. The
genus Lavender exhibits various biological activities, including antioxidants, antiparasitic, and
neuroprotective properties. Recent studies have demonstrated the numerous biological activities
of Lavandula, but we still need to develop new medications that harness the components of this
plant to treat a variety of illnesses. This study covers various recent advancements in the use of
Lavender and its phytochemicals by using various search engines, including Scopus, PubMed,
Google Scholar, and Web of Science.
Exploring the Therapeutic Potential of Bixa orellana L. Phytochemicals in
Oxidative Stress and Complications Using Network Pharmacology
Authors: Akthar Wasim , Ekbbal Rustam , Sharma Himanchal 
Published: February 2025

Introduction:
This study explores the therapeutic potential of Bixa orellana (B. orellana),
focusing on its bioactive compounds and antioxidant effects. Phytochemical analysis combined
with network pharmacology was employed to investigate its multi-targeted therapeutic potential
against oxidative stress.

Methods:
The antioxidant activity of B. orellana flower extract was determined using DPPH assays.
High-performance thin-layer chromatography (HPTLC) and liquid chromatography-mass
spectrometry (LC-MS) were performed to profile key bioactive constituents. Network pharmacology
analysis linked to these phytochemicals was performed to determine its role in oxidative
stress and associated complications.

Results:
The results showed a significant DPPH activity of the flower extract of B. orellana.
HPTLC profiling showed several major and minor metabolites at different Rf values, while LCMS
profiling revealed quercetin, kaempferol, genestin, etc, as key components of the flower extract.
In network pharmacology analysis, quercetin showed a significant interaction with genes
like TP53, NOS2, and CAT, while kaempferol targeted SOD2 and NFE2L2, both crucial in oxidative
stress regulation. The results highlight the multi-targeted approach of B. orellana flower
extract compounds in modulating oxidative stress pathways.

Conclusion:
This comprehensive approach revealed multiple molecular pathways influenced by
B. orellana compounds, providing a strong foundation for their therapeutic potential in oxidative
stress-related diseases.
An Insight into Research Advances on Herbal and Phytochemical Approaches to the Management of Hepatocellular Carcinoma from January 2020 to July 2024
Authors: Nooreen Zulfa , Harer Sunil , Rai Awani Kumar , Wal Ankita , Nathiya Deepak , Kaur Parjinder 
Published: February 2025

Background:
Hepatocellular Carcinoma (HCC) is a primary hepatic tumor and is one of the world's
third most frequent malignancies after lung and colorectal. After stomach, lung, and colorectal cancers, it is the
most common cause of cancer-related mortality. Since the Palaeolithic era, herbs have been used as an essential
source of alternative drugs. Modern cancer treatments that use chemotherapeutic medications are made of chemicals
derived from plants.

Objective:
The present review is about the compilation of phytochemical extracts and molecules from 2020 to
July 2024.

Methods:
A detailed literature survey was conducted to compile data from PubMed, Sci Finder, Science Direct,
Google, etc.

Results:
The identification of novel treatments and their combinations for usage in the adjuvant context potentially
address significant unmet needs in the management of HCC. A large number of investigations have been carried
out these days on plants. Numerous phytochemicals included in plant extract may possess anti-cancer properties,
including the ability to induce cell cycle arrest, suppress cell proliferation, increase apoptosis, and obstruct
migration, invasion, and metastasis. These approaches possess less hazardous and more effective treatment in
HCC.

Conclusion:
This article is the compilation of data about research on phytomolecules and herbal extracts from
January 2020 to July 2024 for the treatment of HCC in vitro and in-vivo. Various mechanisms involved in the
treatment are also explored in the article. The growing interest of researchers in investigating new approaches
toward HCC management with phytomolecules is rapidly growing.
A Bibliometric Analysis on Urticaria: Roles of Oxidative Stress, Inflammation, Immunity, and Treatment Modalities
Authors: Zeeshan Hafiz Muhammad , Bin Heyat Md Belal , Sultana Arshiya , Bin Hayat Mohd Ammar , Sayeed Eram , Akhtar Faijan , Benkmil Nouhayla , Abbasi Rashid , Abdelgeliel Asmaa Sayed 
Published: February 2025

Abstract:
This study provides a comprehensive bibliometric analysis of global research on urticaria,
aiming to chart its progression, assess its relevance, and explore the roles of oxidative
stress, inflammation, and immunity in its pathogenesis. Additionally, by analyzing data from
PubMed and Scopus, we mapped research trends, identified leading authors and institutions, and
examined global collaboration patterns. We also evaluated the impact of oxidative stress, inflammation,
and immunity on urticaria and assessed the roles of both conventional and traditional
medicine in its management. The results highlight the evolution of urticaria research, key
contributors, thematic developments, and collaborative networks. This study offers a detailed
bibliometric profile and thematic map, including insights into effective authors, prominent keywords,
and significant research patterns. The findings are valuable for medical researchers,
providing an updated overview of current themes and gaps, and are also beneficial for
healthcare decision-makers by summarizing relevant information for strategic planning and fostering
new collaborations. Additionally, the study integrates biological aspects related to urticaria
with insights into traditional treatments, contributing to both research and practical management
strategies.
Activity Trackers in Physical Therapy for People With Chronic Obstructive Pulmonary Disease in the Netherlands: Cross-Sectional Study on Current Use and Implementation Determinants
Authors: Ummels Darcy , Bols Esther , Frantzen Roel Johannes Anna , Frantzen Tim , Robeerts Levy , Beekman Emmylou 
Published: February 2025

Abstract

Background
In the Netherlands, 545,900 people experienced chronic obstructive pulmonary disease (COPD) in 2022. Physical therapy following the Royal Dutch Society for Physiotherapy (Koninklijk Nederlands Genootschap voor Fysiotherapie) guidelines for COPD treatment is a proven effective treatment for people with COPD. The revised guidelines include a new recommendation: a patient’s physical activity level should be assessed with an activity tracker (AT). Literature shows that the implementation of eHealth in clinical practice, in this case, ATs, is challenging.

Objective
This study aims (1) to assess how and why ATs are currently used in physical therapy in patients with COPD and (2) to determine which barriers and facilitators are of relevance for optimal implementation of ATs during the clinical reasoning process of physical therapists in patients with COPD.

Methods
A cross-sectional study was used to evaluate the implementation of ATs in physical therapy. Included participants were physical therapists who were affiliated with Chronisch ZorgNet and had a specialization in COPD treatment. The survey content was based on the Consolidated Framework for Implementation Research, the theory of planned behavior, the framework “experiences of patients with commercially available ATs,” and the Koninklijk Nederlands Genootschap voor Fysiotherapie guidelines for COPD. Physical therapists were questioned via a digital survey.

Results
In total, 211 completed surveys were analyzed. Of the 211 participating physical therapists, 108 (51.2%) used ATs, whereas most of them (n=82, 75.9%) already used ATs before it was advised in the guidelines. Physical therapists indicated that the most important reason to use ATs is that they experience it as an added health care value. Both users and nonusers indicated that the most important reason why they do not use ATs is because their patients do not want to use an AT. The second reason was a lack of knowledge in the nonuser group. Moreover, both users and nonusers indicated that the implementation of ATs was not prepared and planned for within their center.

Conclusions
Overall, these results show that ATs are not yet fully implemented in the Dutch general physical therapy practice in patients with COPD, as recommended by current evidence-based guidelines. Physical therapists need guidance for the successful implementation of ATs. This could be accomplished by providing training for physical therapists, integrating ATs into the education of (future) physical therapists, and providing support during the implementation process of ATs for both the physical therapists and management.
A Call for Action: Lessons Learned From a Pilot to Share a Complex, Linked COVID-19 Cohort Dataset for Open Science
Authors: Amid Clara , van Roode Martine Y , Rinck Gabriele , van Beek Janko , de Vries Rory D , van Nierop Gijsbert P , van Gorp Eric C M , Tobian Frank , Oude Munnink Bas B , Sikkema Reina S , Jaenisch Thomas , Cochrane Guy , Koopmans Marion P G 
Published: February 2025

Abstract
The COVID-19 pandemic proved how sharing of genomic sequences in a timely manner, as well as early detection and surveillance of variants and characterization of their clinical impacts, helped to inform public health responses. However, the area of (re)emerging infectious diseases and our global connectivity require interdisciplinary collaborations to happen at local, national and international levels and connecting data to understand the linkages between all factors involved. Here, we describe experiences and lessons learned from a COVID-19 pilot study aimed at developing a model for storage and sharing linked laboratory data and clinical-epidemiological data using European open science infrastructure. We provide insights into the barriers and complexities of internationally sharing linked, complex cohort datasets from opportunistic studies for connected data analyses. An analytical timeline of events, describing key actions and delays in the execution of the pilot, and a critical path, defining steps in the process of internationally sharing a linked cohort dataset are included. The pilot showed how building on existing infrastructure that had previously been developed within the European Nucleotide Archive at the European Molecular Biology Laboratory-European Bioinformatics Institute for pathogen genomics data sharing, allowed the rapid development of connected “data hubs.” These data hubs were required to link human clinical-epidemiological data under controlled access with open high dimensional laboratory data, under FAIR (Findable, Accessible, Interoperable, Reusable) principles. Based on our own experiences, we call for action and make recommendations to support and to improve data sharing for outbreak preparedness and response.
From Competition to Configuration
Authors: Ghea Anissah Trinanda  
Published: February 2025

This article examines the transformation of two types of knowledge—government/official knowledge, which represents "scientific" and “expertise”; and local knowledge, represented by the "Jalin Merapi" community, considered as “non-scientific” and layman's understanding. Both types of knowledge are linked by a common "boundary object" (Gieryn, 1983) of Mount Merapi, but they are often in a competition to influence public discourse. The main argument of this article is that integrating government/scientific and local/non-scientific knowledge can result in more effective disaster mitigation strategies. However, in Indonesia, there is a significant gap between these two types of knowledge systems, and competition often overshadows collaboration. Using a qualitative case study approach, the research highlights a shift in knowledge dynamics, from competition to collaboration, facilitated by the "Jalin Merapi" community. Despite this progress, the inclusion of local knowledge in policy making in Indonesia remains limited. This finding emphasises the importance of more inclusive policies that combine scientific knowledge with local insights to improve disaster management system in Indonesia.
Problem Based Video Learning on Civic Education Content for Third Grade of Elementary School
Authors: Safitri Eka , Suartama I Kadek , Simamora Alexander Hamonangan 
Published: February 2025

Currently, the civic education learning outcomes of elementary school students are still in the low category. This is due to the lack of learning media that can be used. This development research aims to analyze the design, validity and effectiveness of problem-based learning videos on class III civic education content. This research uses the ADDIE development model. The subjects in this research were subject content experts, design experts, media experts, 3 students for individual trials, and 6 students for small group trials. Data collection was carried out using questionnaires and tests. Data analysis techniques use qualitative data analysis, quantitative descriptive data analysis, and inferential statistical data analysis (t-test). The research results show that the video development design includes the stages of analysis, design, development, implementation and evaluation. The assessment of learning media experts showed a percentage of 82.35%, design experts 90.25%, material experts 81.66%, individual trials 96.20%, and small group trials 90.52%. This learning video is effective for use in class III civic education content, especially material on ethnic diversity. It can be concluded that the problem-based learning video innovation in class III civic education content is in very good qualifications and is effectively used to improve student learning outcomes. This research has implications for improving the quality of civic education learning through quality media.
Powtoon Learning Media Containing Local Wisdom Improves Elementary School Social Sciences Learning Outcomes
Authors: Permatasari Devita Dwi , Setyasto Novi 
Published: February 2025

The lack of social studies learning media has an impact on low student learning outcomes. This research aims to develop powtoon learning media containing local wisdom to improve elementary school social studies learning outcomes. This type of research is Research and Development (R&D) using the Borg and Gall development model. This research involved media experts and material experts. The test subjects for this research were 26 elementary school IV student participants. Data collection were carried out using interviews, observation, documentation, questionnaires and tests. This research uses questionnaire instruments and test questions in data collection. The data collected was analyzed using qualitative, quantitative, and t-test descriptive analysis. The results of the research show that Powtoon learning media containing local wisdom was declared "very feasible" by media experts with a percentage of 96.8% and a percentage of 95% by material experts. The responses given by students received a percentage of 95% which was included in the "very appropriate" category. The t-test results show a significant difference between the learning outcomes of pre-test and post-test data. It can be concluded that the innovation of Powtoon learning media containing local wisdom in social studies learning, especially class IV economic activities, can improve social studies learning outcomes for class IV students. This research has implications for improving student learning outcomes and the effectiveness of learning through Powtoon media containing local wisdom in social studies learning in elementary schools.
Brief Survey of Current Oral Tobacco and Nicotine Product Use in Sweden and Denmark
Authors: Prasad Krishna , Edward Lauren 
Published: February 2025

Summary
Exclusive use of Swedish snus is associated with a reduction in associated health risks as compared with cigarette smoking. Similar to Swedish snus but without tobacco, modern oral nicotine pouches are smokeless nicotine products with the potential to offer similar or greater reductions of risks associated with tobacco use. Currently, little is known about the use prevalence of these products in established markets for Swedish snus. In this descriptive study, two market research surveys were conducted in 2019 among 18–64-year-olds in Sweden (n = 7003; male, 51.1%) and Denmark (n = 4402; male, 50.5%) on use of these oral tobacco and nicotine products in order to explore basic user demographics and average daily consumption (ADC) of oral nicotine products. In Sweden, 18.5% of participants reported currently using oral products (17.1% snus; 1.4% nicotine pouch), while only 11.0% smoked cigarettes. In Denmark, by contrast, 20.5% of participants reported currently using cigarettes, whereas 3.2% used oral products (0.8% snus; 2.4% nicotine pouch). More men than women reported using oral products in both countries, and most oral product users were younger than 45 years. The ADC of all oral products was 11.1 pouches/day in Sweden, but only 5.6 pouches/day in Denmark, where nicotine pouch use was predominant. In summary, Swedish snus continues to account for most oral tobacco or nicotine product use in Sweden, but nicotine pouch use has surpassed snus use (2.4% vs. 0.8%) in Denmark. Tobacco users who switch to nicotine pouches may reduce their health risks as compared to continuing tobacco product use, and nicotine pouches can contribute to tobacco harm reduction for the population as a whole.