bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novemberi felkelés híreinek tematizálása az Erdélyi Híradó és a Jelenkor reformkori hírlapokban
Authors: Döbör András 
Published: June 2024

Tanulmányom célja a hírszerkesztés és a tematizálás újságírói módszerének ábrázolása a reformkori magyar nyelvű sajtóban, az Erdélyi Híradó és a Jelenkor 1830‒1832 között megjelent lapszámainak a lengyel nemzeti felkelés hírei tükrében. Az 1830. november 29-én Varsóban kirobbant novemberi felkelésről, amely fegyveres konfliktus 1830‒1831 között háborúvá változott a lengyelek és az Orosz Birodalom között, az 1830-as évek első felében kiadott, a politikai beszédmódvizsgálatba bevont reformkori magyar hírlapok (Jelenkor, Erdélyi Híradó) a cenzúra adta keretek között igyekeztek tudósítani, egészen a lengyel nemzeti felkelés vérbe fojtásáig.
A reformkori hírszerkesztők által felhasznált és a lapba szerkesztett külpolitikai híranyag kapcsán a tartalomvizsgálaton túl szükségesnek mutatkozik a sajtótörténeti elemzések során a beszédmód vizsgálata, a hírekhez fűzött rövid kommentárok, valamint a hírek válogatásának, a politikai üzenetek tematizálási kísérleteinek elemzése. Tanulmányomban bemutatom, hogy noha az általam elemzett magyar lapok külpolitikai híreiben az 1830-as években a szomszédos országok vonatkozásában számszerűen a legkisebb figyelmet Lengyelország kapta, a közvetlen lengyel területekről érkező tudósítások mellett az angol, francia, német, orosz hírek között, elsősorban nyugat-európai és bécsi lapokból válogatva megtalálhatók a lengyelországi helyzetre, illetve a lengyel emigrációra vonatkozó hírek.
VALUATION OF MODERN TECHNOLOGIES USED IN THE ORGANIZATION OF PROJECT ACTIVITIES OF PEDAGOGICAL COLLEGE STUDENTS
Authors: Миронов С.А. 
Published: June 2024

В статье рассматривается внедрение современных цифровых технологий в учебный процесс педагогического колледжа в контексте реализации проектного подхода. Цель исследования – проанализировать преимущества, проблемы и последствия внедрения технологий в проектное обучение студентов педагогических колледжей. Выделены четыре категории используемых в учебном процессе цифровых технологий: 1) средства связи; 2) утилиты для редактуры и презентации проекта; 3) средства планирования и организации проекта; 4) электронные базы; выявлены их преимущества и недостатки. Проведенная в исследовании оценка технологий и предложенные в статье практические рекомендации помогут заинтересованным педагогам колледжей лучше ориентироваться в применении цифровых технологий в рамках проектно-ориентированного обучения.
The article addresses the issues related to the introduction of modern digital technologies in the educational process of pedagogical college in the context of the project approach implementation. The purpose of the study is to analyze the benefits, problems and consequences of the introduction of digital tools in the project training at pedagogical colleges. The author identifies four categories of digital tools used in the educational process: 1) means of communication; 2) utilities for editing and presentation of the project; 3) means of planning and organization of the project, and 4) electronic bases and digital libraries, and analyzes their advantages and disadvantages. The author’s evaluation of the implemented tools and the practical recommendations proposed in the article will help the interested teachers of colleges to better navigate in the sphere of digital technologies implementation within the framework of project-oriented training.
Probiotic, bacillus amyloliquefaciens from milk sample of a native cow ‘Kangeyam’ breed in forest fringe village of Coimbatore, Tamil Nadu and value addition thereof
Authors: Natchiappan Senthilkumar , Ramasamy Sumathi , Gokul Prithvi , Arumugam Vijaya Chitra 
Published: June 2024

Probiotics include good microorganisms that support the body's ability to operate and stay healthy. These good bacteria have several advantages, including as helping us feel better and warding off bad bacteria when there are too many of them in the stomach. Milk samples from the native indigenous Kangeyam breed cattle reared in the tribal hamlets on the forest fringes of Coimbatore were collected to isolate the beneficial microorganism. The sample is specifically collected from such region as it might have a higher efficiency in comparison with domesticated livestock. The milk samples collected were processed and analyzed for their nutritional value. Milk samples obtained from the native indigenous Kangeyam breed cattle reared in tribal hamlets of forest fringe villages was found to be more efficient in the nutritional aspects as like the difference in the milk from regular domesticated cattle. The quality of the milk was tested and then the probiotics were isolated. The pure culture was obtained in which the basic confirmatory tests such as Gram staining, Motility, IMViC, Catalase, Oxidase, Urease, Gas from glucose, Triple sugar iron test, etc., were done. Culture with more accurate results was made for molecular identification by 16srRNA method, in which the species Bacillus amyloliquefaciens has been confirmed and submitted to NCBI. The probiotic was found to be beneficial. The safety assessment was studied for accepted intake. Then the culture was made frozen, which was further lyophilized to be made into powder. The isolated probiotic with significant health benefits can be considered as a probiotic infused value-added product with commercialization potential.
Latent iron deficiency in Indian women and children: A descriptive analysis
Authors: Badami Rajshree , Sanjana S.N , Vasani Rushabh , Tuniki Vishal , Kapoor Neelesh , Gulati Sankalp 
Published: June 2024

Iron deficiency is a global health concern, particularly in developing countries like India. While overt iron deficiency anemia (IDA) is well-documented, Latent Iron Deficiency (LID), a precursor to IDA, remains under-recognized. This study aims to elucidate the proportion of the Indian population with latent iron deficiency and underscore the importance of early detection of this condition.: 344624 anonymized medical records available through a personal health record (PHR) application developed by Eka Care, a health information technology company, were analysed. The ethical handling of data ensured that no personally identifiable information (PII) was accessible or utilized during the research process.: Children aged 5-15 years had a LID prevalence of 32.7% (95% CI:27.4%,37.9%) while women aged 15-49 years had a prevalence of 31.5% (95% CI:30.3%,32.6%). 9% (95% CI: 8.5%,9.5%) of men in the same age group had LID.This study revealed a significant burden of latent iron deficiency among Indian women and children. By implementing targeted screening and intervention strategies, one can improve health outcomes and break the cycle of iron deficiency in these vulnerable populations.LID poses a serious risk for developing iron deficiency anemia (IDA) during and after pregnancy. Iron deficiency can adversely affect maternal and fetal health.This burden of LID highlights the critical need for routine screening and early intervention to prevent these adverse outcomes.
La relación del poder judicial con el poder ejecutivo en la Ley de Tribunales de 1870
Authors: Rodríguez Rubio Carmen 
Published: June 2024

La Constitución española de 1869 ha sido considerada la Carta Magna del liberalismo español. Tras su promulgación tuvo lugar la aprobación de la Ley sobre Organización del Poder Judicial de 1870, ley que supuso el nacimiento del tercer poder del Estado en España. Por mediación de la Ley de Tribunales de 1870 se unificó el acceso a la carrera judicial y fiscal mediante oposición. Igualmente, la ley mencionada dispuso la presencia del Gobierno en diversos ámbitos del poder judicial en relación con la Junta calificadora actuante en el acceso a la judicatura, la tramitación de los expedientes de los opositores y el ingreso y ascenso de los jueces. Asimismo, su intervención fue manifiesta, dentro de la Administración de Justicia, en la inspección de los juzgados y tribunales. Finalmente, en relación con el Ministerio Fiscal, la ley dispuso una organización jerarquizada y ordenada por categorías en la que el Fiscal del Tribunal Supremo se situaba bajo la dependencia del Ministro de Gracia y Justicia.
Recibido: 25.04.2024 Aceptado: 10.05.2024
La vivienda como derecho fundamental. Compromisos internacionales más allá del principio rector
Authors: Terrádez Salom Daría 
Published: June 2024

El presente trabajo tiene como objetivo principal constatar que, pese a que el derecho a la vivienda se haya consagrado en nuestra Constitución como un Principio rector de la política social y económica, las obligaciones internacionales que posee España, tras la ratificación de la Carta Social Europea revisada y del Pacto Internacional de Derechos Económicos, Sociales y Culturales y de la asunción de sus sistemas de control, dan un nuevo sentido al derecho establecido en el artículo 47 de la Constitución española, dotándolo de mayor fuerza vinculante y, sobre todo, de mayores garantías. Este análisis del derecho fundamental a la vivienda no puede desvincularse del principio de indivisibilidad de los derechos humanos y del respeto de la dignidad de la persona, ejes centrales del estudio.
Recibido: 19.12.2023Aceptado: 10.05.2024
PRIMARY FAMILY CAREGIVER PSYCHOLOGICAL STRESS OF STROKE SURVIVORS AT RSUD DR. H. SLAMET MARTODIRJDJO PAMEKASAN
Authors: Rizkiyah Apriliyanti Itsnatur , Martini Santi , Aziz Rahman Muhammad , D. Dela Rosa Ronnel 
Published: June 2024

Background: Primary Family Caregiver (PFC) has a vital role in providing care for stroke survivors and meeting their needs during a long-term recovery period. However, the PFC of stroke survivors experienced stress from a low level to a very high level. Purpose: Research to analyze the PFC psychological stress of stroke survivors has been conducted in Pamekasan. Methods: This type of research is a quantitative, analytic survey, and cross-sectional approach. The research subjects were 103 PFC ischemic stroke survivors who were outpatients at RSUD Dr. H. Slamet Martodirdjo Pamekasan. The sampling technique in this study was simple random sampling. The Depression Anxiety Stress Scale (DASS) questionnaire has been used to measure PFC stress levels. Results: Spearman-Rho analysis between education and stress level showed a correlation coefficient 0.22 with p = 0.02 (p <0.05). This result means that there is a positive relationship between the two variables. However, age, gender, occupation, income, and kinship relationships did not have a significant relationship with the PFC psychological stress of stroke survivors. Conclusion: There is a positive relationship between education and stress levels. Health workers can form the PFC communities to help increase knowledge, skills, and coping strategies.
Parenting Foundation Class: “Mewarnai” Sebagai Sarana Membangun Secure Attachment Orang Tua dan Anak
Authors: Nursyafitri Dita Dwi , Iriyanto Thomas , Astuti Wuri 
Published: June 2024

Program parenting memfasilitasi orang tua dan anak untuk mengasah bakat dan minat di bidang seni khususnya “mewarnai”. Selain terbilang unik program ini juga diharapkan dapat membangun secure attachment antara orang tua dan anak, serta sekolah dapat mengimplementasikan program pelibatan orang tua dalam proses pembelajaran dan stimulasi tumbuh kembang anak. Jenis penelitian yang digunakan yaitu kualitatif deskriptif. Tujuan penelitian ini yaitu mengetahui gambaran umum pelaksanaan program Parenting Foundation Class “Mewarnai”, faktor pendukung dan penghambat dalam pelaksanaanya, serta dampak dari pelaksanaannya terhadap secure attachment. Terdapat tiga langkah analisis data yang meliputi reduksi data, penyajian data, dan penarikan kesimpulan dengan menggunakan instrumen berupa wawancara dan dokumentasi. Hasilnya pelaksanaan program parenting di lembaga tersebut dilaksanakan setiap hari jumat di 3 bulan pertama setiap semester dan diikuti oleh orang tua dan anak. Orangtua dan anak menjadi lebih dekat karena ada komunikasi saat mewarnai, anak merasa aman dan nyaman berada di dekat orangtua, serta lebih percaya diri dalam mengeksplorasi lingkungannya dikarenakan memiliki figur yang melindungi. Faktor yang menjadi pendukung yaitu pemateri yang kompeten dan fasilitas lembaga yang memadai, sedangkan faktor yang menjadi penghambat dalam pelaksanaannya yaitu kesibukan orangtua dihari pelaksanaan dan tidak ada aktivitas tambahan untuk anak yang telah selesai mewarnai sehingga berpotensi mengganggu teman-temannya yang belum selesai mewarnai.
Meningkatkan Keterampilan Sosial Anak dengan Autism Spectrum Disorder (ASD) dengan metode DIR Floortime: Systematic Literature Review
Authors: Fajriyati Riza , Djoehaeni Heny , Romadona Nur Faizah 
Published: June 2024

Keterampilan sosial adalah aspek penting dalam kehidupan sehari-hari. Anak-anak dengan Autism Spectrum Disorder sering mengalami kesulitan dalam berketerampilan Sosial. Oleh karena itu, diperlukan intervensi yang efektif untuk membantu mereka mengatasi kesulitan ini. Penelitian ini bertujuan untuk mengetahui keefektifan penerapan DIR/Floortime® terhadap kemampuan Keterampilan Sosial anak ASD dan pengaruh pendekatan DIR/Floortime® terhadap kemampuan Keterampilan Sosial anak ASD. Peneliti menggunakan metode systematic literature review terhadap studi literatur 20 artikel mengenai penerapan DIR/ Floortime pada anak dengan Autism Spectrum Disorder (ASD) untuk meningkatkan keterampilan sosial. Artikel-artikel yang dipilih kemudian dianalisis secara kualitatif untuk mengidentifikasi temuan-temuan utama terkait dengan penerapan DIR/Floortime® pada anak-anak dengan ASD untuk meningkatkan keterampilan sosial. Hasil kajian diperoleh bahwa pendekatan floortime efektif diterapkan untuk mengembangkan kemampuan Keterampilan Sosial anak ASD. Rekomendasi untuk penelitian selanjutnya dapat digali lagi lebih dalam tentang faktor-faktor apa saja yang dapat memoderasi atau memediasi hubungan antara penerapan DIR/Floortime® dan peningkatan keterampilan sosial pada anak-anak dengan ASD.
Proficiency Testing Program for Screening Drug Testing Laboratories in the Philippines, 2009-2019
Authors: Misolas Augosto , Eulogio Maria Veronica , Go Marites , Magat Laura , Castillo Evangeline , Deoduco-Mercado Jennifer 
Published: June 2024

Background. According to the guidelines of the Department of Health (DOH)’s Health Facilities and Services Regulatory Bureau (HFSRB), accreditation of drug testing laboratories (DTLs) requires annual participation in a proficiency testing (PT) program. Since 2009, the National Reference Laboratory for Environmental and Occupational Health, Toxicology and Micronutrient Assay of the East Avenue Medical Center (NRL-EAMC) has conducted the PT program for DTLs.

Objectives. This article aims to provide a general overview of the PT program conducted for screening drug testing laboratories (SDTLs) and to examine data on laboratories’ participation and performance in the PT program.

Methodology. Laboratories registered for the PT program were given ten 3-mL synthetic urine specimens which may or may not contain drugs of abuse such as methamphetamine and tetrahydrocannabinol at or above the cut-off level. Laboratories analyzed the PT specimens using immunoassay test kits. The results of the analysis were reported back to NRL-EAMC. The performance of the laboratories in the PT depends on the number of incorrect responses.

Results. For ten years (2009-2019), 1102 ± 188 laboratories annually participated in the program. The mean passing rate was 96.6 ± 4.8%. The number of laboratories which initially failed the PT program significantly decreased from 2009 (15.1%) to 2012 (1.5%). From 2013 to 2019, only below 2.5% of the participating laboratories initially failed the PT. On average, 48.4 ± 18.4% of the laboratories achieved an excellent performance, 34.0 ± 13.6% had a highly satisfactory performance, and 14.3 ± 5.4% got an acceptable performance.

Conclusion. The continued decreasing number of laboratories which failed the PT signifies the improvement of laboratories in urine drug testing. In general, some laboratories participating in the PT for the first time are the ones which initially fail the PT which could be due to a lack of experience in handling PT test items. The PT program highlights the effectiveness of quality control procedures being implemented in a drug testing laboratory.
Antiplatelet Effect of Low-Dose Prasugrel in Elderly Patients Undergoing Percutaneous Coronary Interventions
Authors: Verdoia Monica , Nardin Matteo , Gioscia Rocco , Rognoni Andrea , De Luca Giuseppe 
Published: June 2024

Background:
Low-dose prasugrel (5 mg) has been proposed for patients with Acute
Coronary Syndrome (ACS) and advanced age or low body weight. However, the routine use of
dose-adjusted prasugrel in this high-risk subset of patients is still debated.

Aim:
This study aimed to assess the prevalence and predictors of HRPR among elderly patients
treated with low-dose (5 mg) prasugrel to evaluate the routine use of dose-adjusted prasugrel in
this high-risk subset of patients.

Methods:
We included 59 elderly patients (≥75 years) treated with Dual Antiplatelet Therapy
(DAPT: acetylsalicylic acid (ASA) 100-160 mg + prasugrel 5 mg) after Percutaneous Coronary Interventions
(PCI) and undergoing platelet function assessment (by whole blood impedance aggregometry)
30-90 days post-discharge.

Results:
At a median follow-up of 43 days (interquartile range-IQR: 32-54), high-on treatment
residual platelet reactivity (HRPR) occurred in 25 patients (42.4%), who displayed a greater body
mass index (BMI) (p=0.02), lower levels of vitamin D (p=0.05) and were more frequently treated
with nitrates (p=0.03). After multivariate analysis, BMI was the only independent predictor of prasugrel
HRPR, and a BMI >26 was the best cut-off for predicting HRPR (adjusted Odds Ratio -
OR=8.6, 95%CI: 2.2-33.9, p=0.002).

Conclusion:
Among elderly patients receiving DAPT after PCI, HRPR is common with low-dose
prasugrel. A greater BMI, especially for values ≥26, is the only independent predictor of HRPR
with prasugrel 5 mg.
Emerging Trends in Novel Drug Delivery Systems for the Effective
Treatment of Oral Cancer
Authors: Islam Md Moidul , Kumar Ashutosh , Kumar Amit , Mukherjee Debanjan , Kumar Manish 
Published: June 2024

Background:
The consumption of tobacco and alcohol has been correlated with the development
of oral cancer, impacting various areas such as the mouth, lips, tongue, cheeks, and throat.
This condition is marked by irregular cell proliferation involving intricate genetic and epigenetic alterations
that drive tumorigenesis. Traditional treatments face limitations, necessitating a comprehensive
multidisciplinary strategy. Novel Drug Delivery Systems [NDDS] offer groundbreaking therapeutic
possibilities in addressing this complex health challenge.

Objective:
This review emphasizes the use of NDDS in the treatment of oral cancer

Methods:
The review entailed a comprehensive exploration of scientific databases and pertinent publications,
encompassing studies conducted up to the current date sourced from PubMed, Science Direct,
and Google Scholar Key. The search terms incorporated "oral cancer," "novel drug delivery system,"
"chemotherapy," "nanotechnology," and "conventional therapy." The chosen studies underwent
meticulous assessment for methodological robustness and the importance of their findings.

Results:
NDDS serve an important role in targeted medication delivery by increasing drug bioavailability
and reducing adverse effects. Addressing challenges such as low drug solubility, NDDS excels
in sustained release methods, guaranteeing long-term therapeutic impact. Their versatility extends to
the encapsulation of several anticancer drugs, giving a potential option for oral cancer treatment that
is both efficacious and well-tolerated. This novel technique has the potential to transform treatment
approaches, improving the efficacy and tolerability of oral cancer drugs.

Conclusion:
In oral cancer treatment, a spectrum of drug delivery systems is employed, encompassing
conventional methods like oral and intravenous administration alongside innovative approaches
such as vesicular systems, polymeric systems, and targeted strategies. Recent breakthroughs in oral
cancer therapy, including immunotherapy [checkpoint inhibitors, CAR-T cell therapy] and gene therapy
[siRNA, miRNA, CRISPR-Cas9], offer exciting prospects. These advancements hold the potential
for enhanced therapeutic efficacy, minimized side effects, and personalized treatment options.
Current Perspective of Carbazole Scaffolds in Cancer Therapy
Authors: Gupta Muskan , Sharma Shikha , Sahoo Biswa Mohan , Banik Bimal Krishna 
Published: June 2024

Abstract:
Cancer poses a significant threat to human life and well-being, resulting in numerous
individuals suffering and succumbing to various forms of the disease each year. Considerable
resources have been allocated to combat cancer, yet the limitations of existing anticancer agents,
including their side effects and the development of drug resistance, have left substantial challenges
in our quest to conquer cancer. Thus, there is an urgent necessity to discover and develop novel
chemical compounds with the potential to inhibit cancer growth. In this review, we primarily focus
on examining the effectiveness of two distinct classes of carbazole-based compounds: carboline derivatives
and diazacarbazole derivatives. Diazacarbazole derivatives, a relatively unexplored area,
hold promise for offering a fresh perspective and valuable opportunities to overcome the formidable
obstacles in the ongoing battle against cancer. Additionally, we present several synthetic methods
for creating the essential structural frameworks of carbazole-based tricyclic compounds.
Efficacy and Safety of Human Umbilical Cord Mesenchymal Stem Cells in Improving Fertility in Polycystic Ovary Syndrome Mice
Authors: Jin Lukuo , Ren Chenchen , Yang Li , Zhu Yuanhang , Li Genxia , Chang Yun , Du Junxiao , Yang Zhaoyuan , Yuan Yuchao 
Published: June 2024

Background:
Polycystic ovary syndrome (PCOS) is the most prevalent reproductive endocrine
illness in women of reproductive age and is one of the most important causes of female infertility.
The pathogenesis of PCOS is complex. Although mesenchymal stem cell therapy is anticipated
to be a successful treatment for PCOS, its long-term safety, including tumorigenesis in patients,
remains unknown.

Objective:
This study aimed to confirm the efficacy and safety of human umbilical cord mesenchymal
stem cells in improving fertility in PCOS mice.

Methods:
In this study, dehydroepiandrosterone (DHEA) was used to construct a C56BL/6 mouse
PCOS model, human umbilical cord mesenchymal stem cells (hUC-MSCs) were used as a treatment,
and the reproductive phenotype was observed in parallel breeding experiments to confirm
the efficacy of the treatment. A 4-month follow-up period, final blood tests, and organ histology
were carried out to confirm the long-term safety of the treatment.

Results:
After hUC-MSCs treatment, the sex hormone disorder of mice was corrected, the morphology
and function of the ovary were improved, the number of offspring was significantly increased
compared to the control group, and no adverse reactions related to stem cell transplantation
such as tumor formation were found within 4 months.

Conclusion:
The treatment of hUC-MSCs is safe and effective in treating PCOS over the long
term.