bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid determination and pharmacokinetics study of lignans in rat plasma after oral administration of Schisandra chinensis extract and pure deoxyschisandrin
Authors: Mao Shilong , Zhang Hai , Lv Lei , Zhu Zhenyu , Zhao Liang , Zhang Guoqing , Chai Yifeng 
Published: September 2010

AbstractA simple, sensitive and rapid method for analysis of six lignans in rat plasma after oral administration of Schisandra chinensis extracts, utilizing liquid chromatography tandem mass spectrometry (LC‐MS), was established and validated. Plasma samples were prepared by one‐step protein precipitation using acetonitrile and the analytes were separated on an SB‐C18 column (100 mm × 3.0 mm, 3.5 µm) with the mobile phase of acetonitrile–water at a flow‐rate of 0.8 mL/min. Analytes were determined in a single‐quadrupole mass spectrometer in the selected ion monitoring (SIM) mode using electrospray source with positive mode. The method was proved to be rapid, sensitive and reproducible, and it was successfully applied to the pharmacokinetic studies of six lignans in rat plasma after oral administration of Schisandra chinensis extracts. In this research, the pharmacokinetics of deoxyschisandrin was also studied following oral administration of the pure deoxyschisandrin. It was found that most of the pharmacokinetic parameters of deoxyschisandrin in the extract were changed significantly compared with those in monomer. The content assay also revealed that the concentrations of the lignan in the extract increased in vivo compared with the pure monomer. Some ingredients in the extract may increase the dissolution of deoxyschisandrin, delay its elimination and enhance its bioavailability in rat. Copyright © 2010 John Wiley & Sons, Ltd.
Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC‐ESI‐MS/MS: application in pharmacokinetics
Authors: Zan Bin , Shi Rong , Wang Tianming , Wu Jiasheng , Ma Yueming , Cheng Nengneng 
Published: September 2010

AbstractA sensitive and specific liquid chromatography–electrospray ionization–tandem mass spectrometric (LC‐ESI‐MS/MS) method was developed and validated to simultaneously quantify 11 active compounds (coptisine, jatrorrhizine, berberine, palmatine, baicalin, baicalein, wogonoside, wogonin, rhein, emodin and aloeemodin) from Xiexin decoction (XXD) in rat plasma. Plasma samples extracted by a single‐step protein precipitation procedure were separated using the gradient mode on a Dikma ODS‐C18 column. Selected reaction monitoring scanning was employed for quantification with switching electrospray ion source polarity between positive and negative modes in a single run. Calibration curves offered satisfactory linearity (r > 0.995) at linear range of 0.47–60 ng/mL for coptisine, jatrorrhizine, berberine and palmatine, 15–1930 ng/mL for baicalin, 20–2560 ng/mL for baicalein, 14–1790 ng/mL for wogonoside, 0.57–72.8 ng/mL for wogonin, 10–1280 ng/mL for rhein, 0.6–76.8 ng/mL for emodin and 3.0–384 ng/mL for aloeemodin. The intra‐ and interday precisions were less than 10.2% in terms of relative standard deviation (RSD), and the accuracies were within ±10.84% in terms of relative error (RE). It was successfully applied to the evaluation of pharmacokinetics after single oral doses of XXD were administered to rats. Copyright © 2010 John Wiley & Sons, Ltd.
Determination of ciprofloxacin in plasma by micro‐liquid chromatography–mass spectrometry: An adapted method for neonates
Authors: Grondin Christel , Zhao Wei , Fakhoury May , Jacqz‐Aigrain Evelyne 
Published: September 2010

AbstractThere are many limitations to conducting pharmacokinetic studies in neonates, both ethical and technical. Regarding technical aspects, the number and volume of samples are limited, and the analytical method to measure drug concentration should be both specific and highly sensitive. In the present report, an analytical method adapted to neonates was developed for the determination of ciprofloxacin plasma concentration. After a simple protein precipitation, analytes were separated on a micro‐liquid chromatography and quantified by mass spectrometry, with D8‐ciprofloxacin as internal standard. The calibration range was linear from 25 to 3000 ng/mL. Intra‐ and inter‐day precision was less than 2.4 and 4.1%, respectively. The acceptance criteria of accuracy (between 85 and 115%) were met in all cases. A plasma volume of 150 µL was required to achieve the limit of quantification of 25 ng/mL. The method was successfully applied to routine monitoring of ciprofloxacin in pediatric patients and also used in preclinical studies. It will be used to determine the population pharmacokinetic parameters of ciprofloxacin in neonates. Copyright © 2010 John Wiley & Sons, Ltd.
Competence to proceed in SVP commitment hearings: Irrelevant or fundamental due process right?
Authors: Fanniff Amanda M. , Otto Randy K. , Petrila John 
Published: September 2010

AbstractSexually Violent Predator (SVP) civil commitment, intended to incapacitate offenders and protect the public, has been implemented in 21 jurisdictions. While respondents in traditional civil commitment proceedings need not be competent to proceed, SVP commitment may present a greater deprivation of liberty and therefore greater procedural protections may be merited. Statutes and case law regarding competence in this context address two issues: competence to challenge unproven sexual offense allegations and competence to participate in the SVP commitment process. Of the 14 states that have addressed the issue, one concluded that respondents must be competent to challenge unproven allegations and one concluded that all SVP respondents must be competent to participate in the commitment process. Differences between SVP and traditional civil commitment, the rationale underlying the competence requirement, and decisions regarding competence in SVP commitment are reviewed to inform debate regarding whether SVP respondents must be competent to proceed with the commitment process. Copyright © 2010 John Wiley & Sons, Ltd.
Capturing environmental affordances: Low‐income families identify positive characteristics of a hotel housing solution
Authors: Lewinson Terri 
Published: September 2010

AbstractThis qualitative study describes the positive characteristics of an extended‐stay hotel as identified by low‐income families that resided there. Interviews were conducted with ten hotel residents using a semi‐structured interview guide and participant photographs to elicit a deeper understanding of experiencing home at a hotel. Framed in the theoretical perspective of environmental affordances, findings suggest that despite discomforts of the hotel environment, residents were still able to enjoy family independence, social engagement, a sense of safety and connection to a community context. The findings of this study may help practitioners gain a balanced perspective of non‐ideal housing conditions for planning interventions. Even in these conditions, positive characteristics can be identified to reinforce family functioning and well‐being. Copyright © 2010 John Wiley & Sons, Ltd.
Fuzzy cognitive maps for the simulation of individual adaptive behaviors
Authors: Buche C. , Chevaillier P. , Nédélec A. , Parenthoën M. , Tisseau J. 
Published: September 2010

AbstractThis paper focuses on the simulation of behavior for autonomous entities in virtual environments. The behavior of these entities must determine their responses not only to external stimuli, but also with regard to internal states. We propose to describe such behavior using fuzzy cognitive maps (FCMs), whereby these internal states might be explicitly represented. This paper presents the use of FCMs as a tool to specify and control the behavior of individual agents. First, we describe how FCMs can be used to model behavior. We then present a learning algorithm allowing the adaptation of FCMs through observation. Copyright © 2010 John Wiley & Sons, Ltd.
Increased risk of severe depression in male partners of women with breast cancer
Authors: Nakaya Naoki , Saito‐Nakaya Kumi , Bidstrup Pernille Envold , Dalton Susanne Oksbjerg , Frederiksen Kirsten , Steding‐Jessen Marianne , Uchitomi Yosuke , Johansen Christoffer 
Published: September 2010

AbstractBACKGROUND:A few small studies published to date have suggested that major psychosocial problems develop in the partners of cancer patients; however, to the authors' knowledge, no studies to date have addressed their risk for severe depression. In a retrospective cohort study, the risk for hospitalization with an affective disorder of the male partners of women with breast cancer was investigated, using unbiased, nationwide, population‐based information.METHODS:Followed were 1,162,596 men born between 1925 and 1973 who were aged ≥30 years at study entry, resided in Denmark between 1994 and 2006, had no history of hospitalization for an affective disorder, and had lived continuously with the same partner for at least 5 years. A Cox regression analysis included detailed clinical information regarding the diagnosis and treatment of breast cancer and on annually updated socioeconomic and health‐related indicators obtained from national administrative and disease registers.RESULTS:During the 13 years of follow‐up, breast cancer was diagnosed in the partners of 20,538 men. On multivariable analysis, men whose partner was diagnosed with breast cancer were found to be at an increased risk of being hospitalized with an affective disorder (hazards ratio, 1.39; 95%confidence interval, 1.20‐1.61), with a dose‐response pattern for the severity of breast cancer. Furthermore, men whose partner died after breast cancer had a significant, 3.6‐fold increase in risk for an affective disorder when compared with men whose partner survived breast cancer.CONCLUSIONS:The results of the current study supported the hypothesis that men whose partner had breast cancer were at an increased risk for hospitalization with an affective disorder. Cancer 2010. © 2010 American Cancer Society.
High genomic grade index associated with poor prognosis for lymph node‐negative and estrogen receptor‐positive breast cancers and with good response to chemotherapy
Authors: Naoi Yasuto , Kishi Kazuki , Tanei Tomonori , Tsunashima Ryo , Tominaga Naoomi , Baba Yosuke , Kim Seung Jin , Taguchi Tetsuya , Tamaki Yasuhiro , Noguchi Shinzaburo 
Published: September 2010

AbstractBACKGROUND:The aim of the present study was to investigate the prognostic value of the genomic grade index for lymph node‐negative and estrogen receptor (ER)‐positive breast cancers of Japanese women treated with adjuvant hormonal therapy alone, as well as the relation between genomic grade index and pathological complete response (CR) to neoadjuvant chemotherapy.METHODS:Genomic grade index was determined by DNA microarray (U133plus2.0; Affymetrix, Santa Clara, Calif) in tumor tissues obtained from lymph node‐negative and ER‐positive breast cancers (n = 105) treated with adjuvant hormonal therapy alone or in breast tumor biopsy specimens (n = 84, Mammotome) obtained before neoadjuvant chemotherapy (paclitaxel followed by 5‐fluorouracil/epirubicin/cyclophosphomide) to investigate the prognostic and predictive values of genomic grade index.RESULTS:Recurrence‐free survival of patients with high genomic grade index tumors was significantly (P < .001) lower than that of patients with low genomic grade index tumors (55% vs 88%, 10 years after surgery). Multivariate analysis demonstrated that genomic grade index was the most important and significant predictive factor for disease recurrence (P = .013) independently of other prognostic factors, including tumor size, histological grade, progesterone receptor, human epidermal growth receptor 2, and Ki67. High genomic grade index tumors showed a significantly (P = .022) higher pathological CR rate for neoadjuvant chemotherapy than low genomic grade index tumors (31.9% [15 of 47] vs 10.8% [4 of 37]).CONCLUSIONS:Genomic grade index is a powerful prognostic factor for lymph node‐negative and ER‐positive tumors treated with adjuvant hormonal therapy alone, and high genomic grade index tumors are more likely to respond to chemotherapy. Genomic grade index also appears to be very useful for decision making regarding the need for adjuvant chemotherapy for lymph node‐negative and ER‐positive breast cancers. Cancer 2011. © 2010 American Cancer Society.
Control and data flow compatibility in the interaction between dynamic business processes
Authors: Ibáñez María José , Álvarez Pedro , Bañares José Ángel , Ezpeleta Joaquín 
Published: September 2010

AbstractIn the coming years, one of the challenges for business processes is to obtain a high degree of flexibility and ability to adapt to the changing contexts. Two key elements for achieving this are the use of Semantic Web technologies and the possibility of decoupling the business and the interaction aspects in a business process. Nevertheless, these solutions open up new challenges related to the necessity of checking whether a set of processes can successfully cooperate. Compatibility questions should be considered from a control flow point of view (the order of the interactions should be appropriate) and also from a data flow point of view (the information exchanged should be—semantically—adequate). In this paper, we concentrate on the compatibility of a set of processes executed in DENEB, a platform for the Development and ExecutioN of wEB processes based on the Net‐within‐Nets formalism and that follows a conversational approach. More specifically, this paper examines whether a set of interactions among a set of processes is compatible and also whether a given (imposed) interaction logic is compatible with a given business logic. Processes and their interactions have been semantically enhanced by means of domain ontologies and compatibility questions are studied using standard Petri net analysis techniques. Copyright © 2010 John Wiley & Sons, Ltd.
Basic operations, completeness and dynamicity of cyber physical socio semantic link network CPSocio‐SLN
Authors: Zhuge Hai , Xu Bei 
Published: September 2010

AbstractCyber Physical Socio Semantic Link network (CPSocio‐SLN) is a model and method for self‐organizing cyber physical socio resources in Cyber Physical Society (CP‐Society). This paper views CPSocio‐SLN as an evolution process through a series of operations, and investigates its basic operations, completeness, and dynamicity. A strategy for efficiently storing and managing CPSocio‐SLN based on the basic operation set is proposed to support efficient query and maintenance. An approach is suggested for simplifying CPSocio‐SLN reasoning by estimating the importance of reasoning at multiple levels. The study of the dynamicity can help understand its basic characteristics. Copyright © 2010 John Wiley & Sons, Ltd.
Performance‐based parallel loop self‐scheduling using hybrid OpenMP and MPI programming on multicore SMP clusters
Authors: Yang Chao‐Tung , Wu Chao‐Chin , Chang Jen‐Hsiang 
Published: September 2010

AbstractParallel loop self‐scheduling on parallel and distributed systems has been a critical problem and it is becoming more difficult to deal with in the emerging heterogeneous cluster computing environments. In the past, some self‐scheduling schemes have been proposed as applicable to heterogeneous cluster computing environments. In recent years, multicore computers have been widely included in cluster systems. However, previous researches into parallel loop self‐scheduling did not consider certain aspects of multicore computers; for example, it is more appropriate for shared‐memory multiprocessors to adopt Open Multi‐Processing (OpenMP) for parallel programming. In this paper, we propose a performance‐based approach using hybrid OpenMP and MPI parallel programming, which partition loop iterations according to the performance weighting of multicore nodes in a cluster. Because iterations assigned to one MPI process are processed in parallel by OpenMP threads run by the processor cores in the same computational node, the number of loop iterations allocated to one computational node at each scheduling step depends on the number of processor cores in that node. Experimental results show that the proposed approach performs better than previous schemes. Copyright © 2010 John Wiley & Sons, Ltd.
Design, implementation and evaluation of a virtual storage system
Authors: Huang H. Howie , Grimshaw Andrew S. 
Published: September 2010

AbstractLarge organizations always have a strong demand for storage from data‐intensive applications and instruments. In this paper, we present the design, implementation, and evaluation of a new virtual storage system, Storage@desk, which can aggregate a large number of distributed machines within an organization to provide storage services with quality of service guarantees. Because storage virtualization is the prominent goal, Storage@desk provides clients with the abstraction of a hard drive by utilizing the Internet SCSI protocol. As such, data access to new storage services is transparent so that clients do not need to modify any existing applications nor change their current practices. Storage@desk replicates data and employs version‐based journaling for high availability. It utilizes a market‐based model for resource management and a feedback controller for automated performance control. We have developed a prototype of Storage@desk that implements the core components. Copyright © 2010 John Wiley & Sons, Ltd.
Interaction of Aromatic Derivatives with Single‐Walled Carbon Nanotubes
Authors: Hung Wei‐Chun , Elias Gracy , Wai Chien M. 
Published: September 2010

AbstractFluorescence of semiconducting single‐walled carbon nanotubes (SWNTs) normally exhibits diameter‐dependent oxidative quenching behaviour. This behaviour can be changed substantially to become an almost diameter‐independent quenching phenomenon in the presence of electron‐withdrawing nitroaromatic compounds, including o‐nitrotoluene, 2,4‐dinitrotoluene, and nitrobenzene. This change is observed for SWNTs suspended either in sodium dodecyl sulfate or in Nafion upon titration with hydrogen peroxide. Benzene, toluene, phenol, and nitromethane do not show such change. These findings suggest the possibility of forming an electron donor–acceptor complex between SWNTs and nitroaromatic compounds, resulting in leveling the redox potential of different SWNT species. The observation appears to provide a new method for modifying the electrochemical potentials of SWNTs through donor–acceptor complex formation.
Hydrothermal Synthesis of a Doped Mn‐Cd‐S Solid Solution as a Visible‐Light‐Driven Photocatalyst for H2 Evolution
Authors: Ikeue Keita , Shiiba Satoshi , Machida Masato 
Published: September 2010

AbstractThe effect of metal doping (i.e., with Cr, Fe, Ni, Cu, Zn, Ag and Sn) on the crystal structure of hydrothermally synthesized Mn1−xCdxS (where x≈0.1) is studied with the aim of enhancing photocatalytic activity. In contrast to the low‐crystalline, undoped solid solution Mn1−xCdxS, Ni doping yields a well‐crystallized wurtzite‐type Mn‐Cd‐S solid solution, which precipitates as planar hexagonal facets of several hundred nanometers in size, together with much larger grains of α‐MnS (>10 μm). By removing inactive α‐MnS through sedimentation, a single phase with composition of Ni0.01Mn0.56Cd0.43S is obtained successfully. The Ni doping achieved a threefold higher photocatalytic activity for H2 evolution from a 0.1 M Na2S/0.5 M Na2SO3 solution under visible‐light irradiation (λ≥420 nm). The apparent quantum yield of 1 wt % Pt‐loaded Ni0.01Mn0.56Cd0.43S measured at λ=420 nm reached 25 %. The enhanced photocatalytic activity is most likely the result of a decreased concentration of defects, responsible for electron–hole recombination, in the active solid‐solution phase and a slightly higher bandgap energy (2.4 eV).
Unified BER and optimum threshold analysis of binary modulations in simple and cascaded Rayleigh fading channels with switched combining
Authors: Chandra Aniruddha , Bose Chayanika , Bose Manas Kr. 
Published: September 2010

AbstractFollowing a unified analytical framework, the bit error rate (BER) of several coherent and non‐coherent binary modulation schemes is derived for a switched diversity system. The two variants of switched combining that have been investigated are switch and stay combining and switch and examine combining. For channel modelling, at first a simple slow flat fading channel is assumed, where the amplitude attenuation obeys the Rayleigh distribution. Later the BER calculations are repeated for cascaded Rayleigh fading channel case. Rayleigh fading is the most popular model for electromagnetic signal propagation in wireless media when both or either of the transmitter/receiver is fixed. On the other hand, when both the transmitter and the receiver are mobile, a cascaded (or double) Rayleigh fading model is better suited. The applicability of these two models, namely simple and cascaded Rayleigh model, has been indicated by several theoretical studies and their suitability is established by various field measurements. In our paper, simple closed‐form BER expressions as a function of switching threshold have been found and optimum switching thresholds have been computed for both these models as well as for both types of diversity combining described earlier. The results presented in this paper can be very useful for communication system designers to analyze link quality of switched diversity assisted systems in various wireless environments. Copyright © 2010 John Wiley & Sons, Ltd.
Efficient three‐party password‐based key exchange scheme
Authors: Lou Der‐Chyuan , Huang Hui‐Feng 
Published: September 2010

AbstractIn three‐party password‐based key exchange protocol, a client is allowed to share a human‐memorable password with a trusted server such that two clients can negotiate a session key to communicate with each other secretly. Recently, many three‐party password‐based key exchange protocols have been developed. However, these proposed schemes cannot simultaneously achieve security and efficiency. Based on elliptic curve cryptography (ECC), this paper will propose a new simple three‐party password‐based authenticated key exchange scheme. The proposed method not only reduces computation cost for remote users and a trusted server but also is more efficient than previously proposed schemes. It is better suited for resource constrained devices, such as smart cards or mobile units. Copyright © 2010 John Wiley & Sons, Ltd.
Cooperative power allocation with partial channel information in multi‐cell multi‐user dual‐hop MIMO relay systems
Authors: Cho Hee‐Nam , Lee Jin‐Woo , Lee Yong‐Hwan 
Published: September 2010

AbstractThis paper considers cooperative power allocation with the use of partial channel state information (CSI) in a multi‐user dual‐hop relay system with multiple antennas. The end‐to‐end capacity can be improved by dynamically allocating the transmit power of the base station and relay according to co‐channel interference caused by the adjacent relays. The proposed scheme allocates the transmit power in association with the eigenvalues and angle difference between the eigenvectors of transmit correlation matrices of the desired and interference channel. It is shown by means of upper‐bound analysis that the end‐to‐end capacity of the proposed scheme can be maximized in highly correlated channel environments when the principal eigenvectors of transmit correlation matrices of the desired and interference channel are orthogonal to each other. It is also shown that the proposed scheme is robust to the channel estimation error. Finally, the performance of the proposed scheme is verified by the computer simulation. Copyright © 2010 John Wiley & Sons, Ltd.