bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eudaimonic Well‐being: Its Importance and Relevance to Occupational Therapy for Humanity
Authors: Hayward Claire , Taylor Jackie 
Published: March 2011

AbstractContemporary critique of the philosophy and theory of occupational therapy has asserted that the mainstream of the profession holds a westernized view of the world and that occupational therapy has been shackled to notions of health/illness and the medical establishment for too long, hampering movement into social and political spheres. Strategies and developments have been proposed to combat these biases, which have included increased cultural relativism and a re‐focus on the subjective experience of occupation. The value placed on “being” in occupational therapy philosophy is described alongside the related terms of occupational integrity and spirituality. Drawing on theory and research from psychology, this paper proposes the construct of eudaimonic well‐being as both relevant and valuable to occupational therapy in re‐conceptualizing the profession, countering some of the central tensions in the identity of the profession and re‐asserting that well‐being through occupation is for all and for humanity. Finally, the paper proposes that well‐being, in a eudaimonic sense, should be advertised and evidenced as a routine outcome of occupational therapy and consolidated into occupational therapy models as a relevant and meaningful concept. Copyright © 2011 John Wiley & Sons, Ltd.
Expression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumors
Authors: Chetcuti Albert , Aktas Safiye , Mackie Nicole , Ulger Celal , Toruner Gokce , Alkan Mualla , Catchpoole Daniel 
Published: March 2011

AbstractBackgroundWilms tumor is the most common pediatric renal malignancy, but the parameters that are important to its invasion capacity are poorly understood. The aim of this study was to identify new proteins associated with the invasion capacity of Wilms tumor.ProcedureGene expression profiles for 15 primary Wilms tumor samples were determined by Affymetrix Genechip® Human Genome Ul33A microarray analysis. The gene expression profiles for selected genes was further confirmed by quantitative RT‐PCR analysis. Immunohistochemical analysis was performed on 25 Wilms tumor cases to confirm expression for Bcl2A1, EphB2, MSX1, and RIN1.ResultsUsing microarray analysis 14 genes showed differential expression (P < 0.05) comparing stage 1 non‐invasive Wilms tumor to stages 2–4 invasive Wilms tumor. The differential expression for Bcl2A1, EphB2, MSX1, and RIN1 was confirmed by quantitative RT‐PCR. MSX1 protein was statistically significantly lower in stages 2–4 invasive Wilms tumor cases compared to stage 1 non‐invasive cases (P = 0.013). EphB2 protein was higher in stages 2–4 Wilms tumor cases compared to stage 1 cases (P = 0.006). There was no statistically significant difference between stages 1 and 2–4 Wilms tumor for Bcl2A1 (P = 0.230) or RIN1 (P = 0.969) at the protein level.ConclusionOur results indicate that MSX1 may be associated with the invasion capacity of Wilms tumors. RIN1 is a downstream effector of RAS and Bcl2A1 functions as an anti‐apoptotic protein. EphB2 is an ephrin receptor and is up‐regulated in invasive tumors but its role needs to be confirmed in further cases of Wilms tumors. Pediatr Blood Cancer 2011; 57: 950–957. © 2011 Wiley‐Liss, Inc.
Twenty‐five year follow‐up of childhood Wilms tumor: A report from the Childhood Cancer Survivor Study
Authors: Termuhlen Amanda M. , Tersak Jean M. , Liu Qi , Yasui Yutaka , Stovall Marilyn , Weathers Rita , Deutsch Melvin , Sklar Charles A. , Oeffinger Kevin C. , Armstrong Greg , Robison Leslie L. , Green Daniel M. 
Published: March 2011

AbstractBackgroundTreatment cures over 90% of children with Wilms tumor (WT) who subsequently risk late morbidity and mortality. This study describes the 25‐year outcomes of 5‐year WT survivors in the Childhood Cancer Survivor Study (CCSS).ProcedureThe CCSS, a multi‐institutional retrospective cohort study, assessed WT survivors (N = 1,256), diagnosed 1970–1986, for chronic health conditions, health status, health care utilization, socioeconomic status, subsequent malignant neoplasms (SMNs), and mortality compared to the US population and a sibling cohort (N = 4,023).ResultsThe cumulative incidence of all and severe chronic health conditions was 65.4% and 24.2% at 25 years. Hazard ratios (HR) were 2.0, 95% confidence interval (CI) 1.8–2.3 for grades 1–4 and 4.7, 95%CI 3.6–6.1 for grades 3 and 4, compared to sibling group. WT survivors reported more adverse general health status than the sibling group (prevalence ratio [PR] 1.7; 95%CI 1.2–2.4), but mental health status, socioeconomic outcome, and health care utilization were similar. The cumulative incidence of SMN was 3.0% (95%CI 1.9–4.0%) and of mortality was 6.1% (95%CI 4.7–7.4%). Radiation exposure increased the likelihood of congestive heart failure (CHF) (no doxorubicin—HR 6.6; 95%CI 1.6–28.3; doxorubicin ≤250 mg/m2—HR 13.0; 95%CI 1.9–89.7; doxorubicin >250 mg/m2—HR 18.3; 95%CI 3.8–88.2), SMN (standardized incidence ratio [SIR] 9.0; 95%CI 3.9–17.7 with and 4.9; 95%CI 1.8–10.6 without doxorubicin) and death.ConclusionLong‐term survivors of WT treated from 1970 to 1986 are at increased risk of treatment related morbidity and mortality 25 years from diagnosis. Pediatr Blood Cancer 2011; 57: 1210–1216. © 2011 Wiley Periodicals, Inc.
Breast cancer survivors' beliefs about the causes of breast cancer
Authors: Panjari Mary , Davis Susan R , Fradkin Pamela , Bell Robin J 
Published: March 2011

AbstractObjective: To explore the beliefs held by breast cancer (BC) survivors about the factors that contribute to the development of their BC. Methods: The BUPA Health Foundation Health and Well‐being after Breast Cancer Study is a prospective cohort study of 1684 women recruited within 12 months of their first diagnosis with invasive BC. Participants completed an enrollment questionnaire (EQ), first follow‐up questionnaire (FQ1) and a second follow‐up questionnaire (FQ2), 12 months and 24 months post‐EQ, respectively. In the FQ2, women were asked whether they believed anything contributed to the development of their BC and whether they had made lifestyle changes since the FQ1. Well‐being was assessed at the FQ2 using the Psychological General Well‐being Index (PGWB). Results: In total, 1496/1684 women completed the FQ2 and 43.5% reported belief in a factor that may have contributed to their developing BC. These women were more likely to be younger (p<0.0001) and educated beyond high school (p<0.0001). Stress (58.1%) was the most common reason given, followed by previous use of hormone therapy (17.0%) and a family history of any cancer (9.8%). Women who believed stress contributed to their BC had lower PGWB scores than other study participants (70.9 ± 16.1, n = 361 versus 77.3 ± 14.9, n = 1071, mean difference = 6.4, 95% CI: 4.6–8.2 p<0.0001) and were more likely to have made lifestyle changes since their BC diagnosis. Conclusions: Many women with BC believe that stress has contributed to their condition. Women who held this belief were more likely to adopt strategies to reduce stress than those who did not. Copyright © 2011 John Wiley & Sons, Ltd.
Electron pairing in one‐dimensional anharmonic crystal lattices
Authors: Velarde M. G. , Brizhik L. , Chetverikov A. P. , Cruzeiro L. , Ebeling W. , Röpke G. 
Published: March 2011

AbstractWe show that when anharmonicity is added to the electron–phonon interaction it facilitates electron pairing in a localized state. Such localized state appears as singlet state of two electrons bound with the traveling local lattice soliton distortion, which survives when Coulomb repulsion is included. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2012
Comparison of the deactivation mechanism of 5‐fluorouracil with that of its parent system, uracil: The need of the use of the MS‐CASPT2 method
Authors: Mercier Yannick , Reguero Mar 
Published: March 2011

AbstractBecause of their biological significance in radiation damage and repair of the genetical material, a detailed understanding of the photophysical properties of DNA bases is very important. The key property in DNA is the ultrafast radiationless decay to the ground state that allows dissipating the energy before harmful photoproducts may be formed. Experimental results in the investigation of uracil suggest that there exist a pair of competitive mechanism for the radiationless deactivation of this basis. It is well established that the key point of its ultrafast radiationless decay is a Sπ/S0 conical intersection [where Sπ is the excited state populated by the photoexcitation, characterized by a 1(π‐π*) excitation], but there are still some point of controversy, like the possible existence and involvement of a stable Sπ species in the deactivation mechanism. Nucleobases tautomers and derivatives usually have different photochemical properties, and in general, they show a slower deactivation mechanism. The study of some derivatives of uracil can be interesting for comparative purposes and to help in the reassurance of the deactivation mechanisms proposed for uracil. This is one of the reasons for developing our study on 5‐fluorouracil (5‐FU), which exhibits much longer lived excited states than the parent system uracil. On top of this, 5‐FU is also of interest by itself because it is used in cancer treatment. We have studied the ground and first excited singlet states of 5‐FU using the complete active space self‐consistent field method (CASSCF)/MS‐complete active space perturbation theory to second order level (CASPT2) protocol that is known to provide accurate results for this type of systems. Minima, potential energy surface (PES) crossings and paths have been characterized and compared with those of uracil. Our results show that for 5‐FU, as opposite to uracil, a minimum exists in the PES of the Sπ state. The involvement of this minimum in the deactivation mechanism together with the presence of a small barrier in the relaxation path toward the Sπ/S0 conical intersection explain the longest decay time of the excited state of 5‐FU. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem 111:3405–3415, 2011
Isatin‐Schiff base copper(II) complexes—A DFT study of the metal‐ligand bonding situation
Authors: Caramori Giovanni F. , Parreira Renato L. T. , Ferreira Ana Maria Da Costa 
Published: March 2011

AbstractHerein, we report results of calculations based on density functional theory (BP86/TZVP) of a set of isatin‐Schiff base copper(II) and related complexes, 1‐12, that have shown significant pro‐apoptotic activity toward diverse tumor cells. The interaction of the copper(II) cation with different ligands has been investigated at the same level of theory. The strength and character of the Cu(II)‐L bonding was characterized by metal‐ligand bond lengths, vibrational frequencies, binding energies, ligand deformation energies, and natural population analysis. The metal‐ligand bonding situation was also characterized by using two complementary topological approaches, the quantum theory of atoms‐in‐molecules (QTAIM) and the electron localization function (ELF). The calculated electronic g‐tensor and hyperfine coupling constants present significant agreement with the EPR experimental data. The calculated parameters pointed to complex 10 as the most stable among the isatin‐Schiff base copper(II) species, in good agreement with experimental data that indicate this complex as the most reactive in the series. © 2011 Wiley Periodicals, Inc. Int J Quantum Chem, 2012
A Formal Framework for Conceptions of Sustainability – a Theoretical Contribution to the Discourse in Sustainable Development
Authors: Christen Marius , Schmidt Stephan 
Published: March 2011

ABSTRACTIn the sustainability discourse we find much disagreement about the idea of sustainability resulting in the unsatisfactory situation that this idea is limited by arbitrariness and therefore looses its action guiding power. Examining various strategies to solve this challenge we argue for a meta‐perspective. In the central part of this paper we describe a formal framework for conceptions of sustainability consisting of fundamental and practical modules. Subsequently, we critically compare this framework with alternative meta‐approaches, in particular with the ‘Framework for Strategic Sustainable Development’. We conclude that the problem of arbitrariness is encountered on three different levels; in the designation of the subject field of the sustainability debate, in the characterisation of sustainability science and indirectly in providing a basis to assess policies. This underlines the framework's usefulness of structuring the discourse on sustainability. Copyright © 2011 John Wiley & Sons, Ltd and ERP Environment.
Micronucleus test and comet assay for the evaluation of zebrafish genomic damage induced by erythromycin and lincomycin
Authors: Rocco Lucia , Peluso Carmela , Stingo Vincenzo 
Published: March 2011

AbstractAn enormous quantity of pharmacologically active principles are currently being introduced into the environment, with consequent escalation of environmental problems, but only a small number of studies are focusing on an assessment of their genotoxic effects. The aim of this article is to assess the genotoxic effects of erythromycin, lincomycin, and of a combination of these two antibiotics on the genome of the zebrafish. The genotoxicity of the two antibiotics was assessed by applying the micronucleus test to erythrocytes and performing a Comet assay on erythrocytes and hepatocytes. The fish were exposed to antibiotics at different concentrations and times of exposure, under standard laboratory conditions. Depending on the different experimental conditions, erythromycin and lincomycin induced a significant increase in DNA migration (tail moment) and a significant increase in micronuleus frequency. We also conducted an analysis on the activation of repair mechanisms when the genotoxic agent was removed. Only a few of the cells displayed a decrease in damage under these test conditions.© 2011 Wiley Periodicals, Inc. Environ Toxicol 2012.
Evaluation of chlorinated benz[a]anthracene on hepatic toxicity in rats and mutagenic activity in Salmonella typhimurium
Authors: Kido T. , Sakakibara H. , Ohura T. , Guruge K. S. , Kojima M. , Hasegawa J. , Iwamura T. , Yamanaka N. , Masuda S. , Sakaguchi M. , Amagai T. , Shimoi K. 
Published: March 2011

AbstractChlorinated benz[a]anthracenes (Cl‐BaA) are halogenated aromatic compounds (typified by dioxins) found in the environment at relatively high concentrations. Fischer 344 rats were intragastrically administered 0, 1, or 10 mg of Cl‐BaA or its parent compound benz[a]anthracene (BaA) per kg of body weight for 14 consecutive days. Both chemicals at 10 mg/kg/day inhibited the gain in body weight, and consequent increase in relative liver weight. Hepatic gene expression of cytochrome P450 (CYP) 1A1, 1A2, and 1B1 was significantly stimulated by administration of BaA (10 mg/kg/day) compared with the control. After administration of Cl‐BaA, only the CYP1A2 gene was significantly induced, even at the lower dosage; CYP1A1 and 1B1 mRNA levels remained unchanged in Cl‐BaA‐treated rats compared with controls. To elucidate the role of such Cl‐BaA exposure and induced CYPs at toxicity onset, we investigated the mutagenicity of BaA and Cl‐BaA using Salmonella typhimurium TA98 and TA100. BaA and Cl‐BaA at 10 μg/plate produced positive results in both strains in the presence of rat S‐9. Incubation of Cl‐BaA with recombinant rat CYP1A2 produced a significantly higher number of revertant colonies in TA98 and TA100 than in controls, but no such change was observed for BaA. In conclusion, BaA changes its own physiological and toxicological actions by its chlorination; (1) daily exposure to Cl‐BaA selectively induces hepatic CYP1A2 in rats and (2) Cl‐BaA induces frameshift mutations in the presence of CYP1A2, although BaA does not exert mutagenicity. This indicates that CYP1A2 may metabolize Cl‐BaA to active forms. © 2011 Wiley Periodicals, Inc. Environ Toxicol 2013.
Congenital disorders of glycosylation (CDG): it's (nearly) all in it!
Authors: Jaeken Jaak 
Published: March 2011

AbstractCongenital disorders of glycosylation (CDG) is a booming class of metabolic diseases. Its number has increased nearly fourfold (to 45) since 2003, the year of the Komrower lecture, entitled ‘Congenital disorders of glycosylation CDG): It's all in it!’. This paper presents an overview of recently discovered CDG and CDG phenotypes, of a diagnostic approach, of (the lack of) treatment, of CDG genetics, of a novel CDG nomenclature and classification, and of some future directions in the CDG field.
Middle Korean ㅿ and the Cheju dialect
Authors: Stonham John 
Published: March 2011

AbstractAll records of Middle Korean are exclusively in the Central dialect, the prestige form spoken in the capital, and all printed material in the newly-created Hangǔl script emanated from there. For this reason, historical studies must rely on modern dialect data for comparison and reconstruction, since there are virtually no early dialect materials. In this study, I investigate the nature of the MK ㅿ, which is most often realized as /Ø/ in Modern Standard Korean, but which often surfaces as /s/ in Southern varieties, including the most conservative of these dialects, Cheju Korean. Sino-Korean forms in Cheju dialect containing an /s/ reflex of ㅿ demonstrate not only that ㅿ was realized as /z/ in such forms, but also that the dialects must have had special phonological rules to deal with their pronunciation. A further important issue concerns the nature of doublets and their treatment in both Middle Korean and Cheju dialect.
‘Letting the Phenomena In’: On How Herman's Kantianism Does and Does Not Answer the Empty Formalism Critique
Authors: Sedgwick Sally 
Published: March 2011

AbstractInMoral Literacy, Barbara Herman informs us that she will defend an ‘enlarged version of Kantian moral theory’ (Herman 2008: ix). Her ‘enlarged version’, she says, will provide a much-needed alternative to the common but misguided characterization of Kant's practical philosophy as an empty formalism. I begin with a brief sketch of the main features of Herman's corrective account. I endorse her claim that the enlarged Kantianism she defends is true to Kant's intentions as well as successful in correcting the objections she outlines. I then argue that there is another version of the empty formalism worry Herman does not address. Not only does she not address it, but her form of Kantianism provides fuel for its fire.
Design of a very low-power, low-cost 60 GHz receiver front-end implemented in 65 nm CMOS technology
Authors: Kraemer Michael , Dragomirescu Daniela , Plana Robert 
Published: March 2011

The research on the design of receiver front-ends for very high data-rate communication in the 60 GHz band in nanoscale Complementary Metal Oxide Semiconductor (CMOS) technologies is going on for some time now. Although a multitude of 60 GHz front-ends have been published in recent years, they are not consequently optimized for low power consumption. Thus, these front-ends dissipate too much power for battery-powered applications like handheld devices, mobile phones, and wireless sensor networks. This article describes the design of a direct conversion receiver front-end that addresses the issue of power consumption, while at the same time permitting low cost (due to area minimization by the use of spiral inductors). It is implemented in a 65 nm CMOS technology. The realized front-end achieves a record power consumption of only 43 mW including low-noise amplifier (LNA), mixer, a voltage controlled oscillator (VCO), a local oscillator (LO) buffer, and a baseband buffer (without this latter buffer the power consumption is even lower, only 29 mW). Its pad-limited size is 0.55 × 1 mm2. At the same time, the front-end achieves state-of-the-art performance with respect to its other properties: Its maximum measured power conversion gain is 30 dB, the RF and IF bandwidths are 56.5–61.5 and 0–1.5 GHz, respectively, its measured minimum noise figure is 9.2 dB, and its measured IP−1 dBis −36 dBm.
Impact of Methicillin-ResistantStaphylococcus aureusPrevalence among S.aureusIsolates on Surgical Site Infection Risk after Coronary Artery Bypass Surgery
Authors: Miller Loren G. , McKinnell James A. , Vollmer Michael E. , Spellberg Brad 
Published: March 2011

Objective.Cephalosporins are recommended for antibiotic prophylaxis to prevent cardiothoracic surgical site infections (SSIs) except in patients withβ-lactam allergy or in settings with a “high” prevalence of methicillin-resistantStaphylococcus aureus(MRSA) among S.aureusisolates (hereafter, “MRSA prevalence”); however, “high” remains undefined. We sought to identify the MRSA prevalence at which glycopeptide prophylaxis would minimize SSIs relative toβ-lactam prophylaxis.Methods.We developed a decision analysis model to estimate SSI likelihood when either glycopeptides orβ-lactams were used for prophylaxis in cardiothoracic surgery. Event probabilities were derived from a systematic literature review. A similar cost-minimization model was also developed.Results.At 0% MRSA prevalence, SSI probability was 3.64% with glycopeptide prophylaxis and 3.49% withβ-lactam prophylaxis. At MRSA prevalences of 10%, 20%, 30%, or 40%, SSI probabilities with glycopeptide prophylaxis did not change, but they were 3.98%, 4.48%, 4.97%, and 5.47% withβ-lactam prophylaxis. The threshold of MRSA prevalence at which glycopeptide prophylaxis minimized SSI probability and cost was 3%. In sensitivity analyses, variations in most model estimates only modestly affected the threshold.Conclusion.Glycopeptide prophylaxis minimizes the risk of SSIs and cost when MRSA prevalence exceeds 3%. At very low MRSA prevalence (between 3% and 10%), the SSI minimization provided by glycopeptide prophylaxis is small and may be within the error of the model. Given the current MRSA prevalence in most community and healthcare settings, clinicians should consider routine prophylaxis with vancomycin. Our findings may have important policy implications, as benefits in cardiothoracic surgery antibiotic prophylaxis must be weighed against the limitations of increased glycopeptide use.