bluuebunny/crossref_metadata_2025_split huggingface dataset:
Separation of isobaric phosphorothioate oligonucleotides in capillary electrophoresis: study of the influence of cationic cyclodextrins on chemo and stereoselectivity
Authors: Ghassemi Maryam K. , Hurlet Vincent , Crommen Jacques , Servais Anne-Catherine , Fillet Marianne 
Published: June 2024

Phosphorothioate (PS) oligonucleotides have drawn more and more attention lately due to their great therapeutic potential. The presence of one (or several) phosphorothioate moiety (ies) improves pharmacokinetic properties but at the same time creates an additional chiral center for each phosphorothioate linkage, and thus diastereomers. It is therefore important to develop analytical strategies to monitor individual species to enable more in-depth investigations. In this study, a PVA coated capillary with a background electrolyte made of 100 mM phosphoric acid adjusted to pH 3.0 with triethanolamine was used. A design of experimental approach provides the optimal conditions for the separation of the eight isobaric diastereomers bearing one phosphorothioate linkage (Mix 1), and the separation of the 12 isobaric diastereomers of a mixture made of oligonucleotides with two phosphorothioate linkages (Mix 2). Remarkably, full separation in Mix 1 could be achieved using a combination of a cationic cyclodextrin (2-hydroxy-3-N,N,N-trimethylamino) propyl-γ-CD chloride, and an anionic cyclodextrin (carboxymethyl-β-cyclodextrin sodium salt), while a second cationic cyclodextrin (2-hydroxy-3-N,N,N-trimethylamino) propyl-β-CD chloride) was required for Mix 2, providing additional selectivity.
Fabrication of magnetic molecularly imprinted polymer-based covalent–noncovalent synergistic imprinting strategies for the highly specific enrichment of luteolin from honeysuckle
Authors: Zhang Liping , Hao Peizhi , He Yifan , Li Shujing , Li Tian , Wang Lan , He Suna 
Published: June 2024

IntroductionLuteolin (LTL) is the primary active ingredient in honeysuckle, which exhibited wide pharmacological activities, including heat-clearing, detoxifying, anti-inflammatory and anti-oxidant effects. The conventional method for the extraction of LTL consumed a substantial amount of time and organic solvents, and poor selectivity. Therefore, fabrication of novel material with simple preparation process, low cost and excellent selectivity is of great significance for the extraction and enrichment of LTL from honeysuckle.ResultsIn this system, a novel surface imprinting polymer for luteolin, denoted as Fe3O4@SiO2@MIP, was synthesized using covalent-noncovalent synergistic imprinting strategies. 3-acrylamidephenylboric acid was adopted as covalent functional monomer, deep eutectic solvent (choline chloride/methacrylic acid (ChCl/MAA, 1/2, n/n)) and methacrylic acid as the non-covalent functional monomers, and Fe3O4@SiO2 nanoparticles as the magnetic support. The resultant Fe3O4@SiO2@MIP displayed a uniform morphology, good crystallinity, and excellent magnetic properties. Meanwhile, the binding experiments demonstrated that Fe3O4@SiO2@MIP exhibited high binding performance and the maximum adsorption capacity was 20.97 mg/g. Moreover, the selectivity and reusability behavior of them were satisfactory. In addition, this polymer, serving as an adsorbent, presented practical application potential in separation and enrichment of LTL from honeysuckle.ConclusionThe covalent-noncovalent synergistic imprinting strategy could greatly facilitate the preparation of imprinted nanoparticles for the specific recognition of LTL, providing a valuable approach for the enrichment of LTL in complex samples.
Associations of Urinary Heavy Metal Mixtures with High Remnant Cholesterol among US Adults: Evidence from the National Health and Nutrition Examination Survey (1998–2018)
Authors: Li Hui , Cheng Bei-Jing , Yang Pei-Yan , Wang Chun , Meng Ke , Li Tian-Lin , Wang Jia , Liu Ran 
Published: June 2024

The main objective of our study is to explore the associations between combined exposure to urinary heavy metals and high remnant cholesterol (HRC), a known cardiovascular risk factor. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018, we conducted a cross-sectional analysis of 5690 participants, assessing urinary concentrations of ten heavy metals. Ten heavy metals in urine were measured by inductively coupled plasma mass spectrometry (ICP-MS). Fasting residual cholesterol ≥0.8 mmol/L was defined as HRC (using blood samples). Statistical analyses included weighted multivariable logistic regression, weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) to evaluate the associations of heavy metal exposure with HRC. Stratified analyses based on individual characteristics were also conducted. Multivariable logistic regression found that the four metals (OR Q4 vs. Q1: 1.33, 95% CI: 1.01–1.75 for barium (Ba); OR Q4 vs. Q1: 1.50, 95% CI: 1.16–1.94 for cadmium (Cd); OR Q4 vs. Q1: 1.52, 95% CI: 1.15–2.01 for mercury (Hg); OR Q4 vs. Q1: 1.35, 95% CI: 1.06–1.73 for lead (Pb)) were positively correlated with the elevated risk of HRC after adjusting for covariates. In addition, all three mixed models, including WQS (OR: 1.25; 95% CI: 1.07–1.46), qgcomp (OR: 1.17; 95% CI: 1.03–1.34), and BKMR, consistently showed a significant positive correlation between co-exposure to heavy metal mixtures and HRC, with Ba and Cd being the main contributors within the mixture. These associations were more pronounced in younger adults (20 to 59 years), males, and those with a higher body mass index status (≥25 kg/m2). Our findings reveal a significant relationship between exposure to the mixture of heavy metals and HRC among US adults, with Ba and Cd being the major contributors to the mixture’s overall effect. Public health efforts aimed at reducing heavy metal exposure can help prevent HRC and, in turn, cardiovascular disease.
Audiological Signs of Meniere’s Disease: A Literature Review
Authors: Марьенко И.П. , Гребень Н.И. , Поддубный А.А. , Смоляк А.М. , Лисоцкая В.В. 
Published: June 2024

Болезнь меньера (БМ) – идиопатическое заболевание внутреннего уха, характеризующееся периодическими приступами системного головокружения, заложенностью, шумом в ушах, снижением слуха и развитием нейросенсорной тугоухости (НСТ). Является распространенным заболеванием, частота которого составляет от 15 до 250 случаев на 100 000 населения. Считается, что эндолимфатический гидропс (ЭГ) является гистологическим маркером БМ. Диагностика БМ в клинической практике представляет собой трудную задачу в связи с многообразием патологических изменений при различных стадиях заболевания и вовлечением в процесс лабиринта внутреннего уха. На сегодняшний день не существует универсального метода диагностики ЭГ, для подтверждения диагноза необходимо проводить аудиологические и вестибулологические методы диагностики и оценивать их в динамике. Результаты исследования слуха и вестибулярного аппарата зависят от стадии заболевания БМ.
Meniere’s disease (MD) is an idiopathic disease of the inner ear characterized by periodic attacks of systemic dizziness, congestion, tinnitus, hearing loss and the development of sensorineural hearing loss (SHL). It is a common disease, the frequency of which ranges from 15 to 250 cases per 100,000 population. In 1938, a histological examination of the temporal bone revealed for the first time endolymphatic hydrops (EH) in a patient during his lifetime having clinically similar symptoms with MD. Since then, it has been believed that EG is a histological marker of MD. Diagnosis of MD in clinical practice is a difficult task due to the variety of pathological changes at various stages of the disease and the involvement of the inner ear labyrinth in the process. To date, there is no universal method of diagnosing EH, to confirm the diagnosis, it is necessary to conduct audiological and vestibulological diagnostic methods and evaluate them in dynamics. The results of the healing of hearing and vestibular apparatus depend on the stage of the MD disease.
Stop Bullying Melalui Edukasi, Attitude Change dan Empathy di Sekolah
Authors: Ida Sofiyanti  , Risma Aliviani Putri  , Isfaizah  
Published: June 2024

Bullying is an imbalance of power that can make others feel uncomfortable, scared, and hurt that is often done due to differences in appearance, culture, race, religion, sexual orientation and gender identity of people. Bully behavior is not only treated physically but can be in the form of words (verbal) either directly or indirectly. Schools are places where children learn, socialize, play, but schools can also be places where children experience bullying or bullying. The lack of knowledge of children about bullying makes children can accidentally bully their themes so that children become perpetrators and victims of bullying. The implementation of the activity was carried out at SDN Sumurrejo 01 Semarang City. The method used is counseling which begins with opening, perception, provision of material, evaluation and conclusion. Data collection instruments are in the form of questionnaires while the media used are visual media. Education about bullying given to students increased their knowledge with an increase in the percentage of knowledge quite good by 36 students (46.75%), good knowledge 30 students (38.96%) and knowledge less 11 students (14.29%). Children’s knowledge about bullying behavior must be known early so as not to have a greater impact in the future because children become perpetrators or victims of bullying.

ABSTRAK
Perundungan atau Bullying adalah ketidakseimbangan kekuasaan yang dapat membuat orang lain merasa tidak nyaman, takut, dan sakit hati yang sering dilakukan dikarenakan adanya perbedaan pada penampilan, budaya, ras, agama, orientasi seksual dan identitas gender orang. Perilaku Bully tidak hanya perlakukan secara fisik namun bisa berupa perkataan (verbal) baik secara langsung maupun tidak langsung. Sekolah menjadi tempat anak-anak belajar, bersosialisasi, bermain, namun sekolah bisa juga menjadi tempat bagi anak-anak mengalami perundungan atau bullying. Kurangnya pengetahuan anak mengenai bullying menjadikan anak bisa saja secara tidak sengaja melakukan perundungan pada temanya sehingga anak-anak menjadi pelaku dan korban bullying. Pelaksanan kegiatan dilaksanakan di SDN Sumurrejo 01 Kota Semarang. Metode yang digunakan adalah penyuluhan yang diawali dengan pembukaan, apersepsi, pemberian materi, evaluasi dan kesimpulan. Instrumen pengumpulan data berupa kuesioner sedangkan media yang digunakan adalah media visual. Edukasi tentang bullying yang diberikan kepada siswa meningkatkan pengetahuan mereka dengan terjadinya kenaikan prosetase pengetahuan cukup baik sejumlah 36 siswa (46,75%), pengetahuan baik 30 siswa (38,96%) dan pengetahuan kurang 11 siswa (14,29%). Pengetahuan anak mengenai perilaku bullying harus diketahui sejak dini agar tidak memberikan dampak yang lebih besar dikemudian hari karena anak menjadi pelaku atau korban bullying.
HUBUNGAN ANTARA BEBAN KERJA DENGAN KELELAHAN KERJA PADA TENAGA KERJA KONTRUKSI BAGIAN FABRIKASI DI PT. SOMATRA POLAREKASARANA
Authors: Subekti Agung Tyas , Rakhmadi Triyono , Pratiwi Anggit 
Published: June 2024

Kelelahan adalah suatu yang terjadi pada syaraf otot – otot manusia sehingga tidak dapat berfungsi lagi sebagaimana mestinya. Makin berat beban yang dikerjakan dan semakin tidak teraturnya pergerakan, maka timbulnya kelelahan akan lebih cepat. Tujuan penelitian adalah untuk mengidentifikasi beban kerja pada tenaga kerja kontruksi bagian fabrikasi di PT. Somatra Polarekasarana, untuk mengidentifikasi kelelahan kerja pada tenaga kerja kontruksi bagian fabrikasi di PT. Somatra Polarekasarana, dan untuk mengetahui hubungan antara beban kerja dengan kelelahan kerja pada tenaga kerja kontruksi bagian fabrikasi di PT. Somatra Polarekasarana. Metode dalam penelitian ini yaitu menggunakan jenis penelitian kuantitatif dengan melakukan survey dimana peneliti mencoba menggali bagaimana dan mengapa fenomena ini terjadi dengan menggunakan pendekatan Cross Secrional. Hasil penelitian : menunjukan bahwa beban kerja didapatkan hasil 12 orang (46,2%) dalam kategori ringan, 14 orang (53,8%) dalam kategori sedang, sedangkan untuk kelelahan kerja 11 orang (42,3%) dalam kategori tidak Lelah , 15 orang (57,7%) dalam kategori Lelah. Hasil uji statistic Chi – Square didapatkan nilai P Value sebesar 0,020. Simpulan penelitian : berdasarkan hasil dan pembahasan dapat disimpulkan bahwa adanya hubungan antara beban kerja dengan kelelahan kerja pada pada tenaga kerja kontruksi bagian fabrikasi di PT. Somatra Polarekasarana dengan nilai P < 0,05 dengan tingkat kepercayaan 80% yaitu sebesar 0,020.
Biodegradable Cutting Fluids Evaluation for Sustainable Machining Processes
Authors: Wofuru-Nyenke Ovundah 
Published: June 2024

Sustainably selecting the best cutting fluid among alternatives, considering various weighted criteria or factors, is a complex problem encountered by machine operators in engineering workshops worldwide. The aim of this work is to utilize the Multi-attribute Utility Theory (MAUT) decision-making model for biodegradable cutting fluids selection in a machine shop. The objectives of the work include carrying out a step-by-step process of the MAUT method on biodegradable cutting fluid alternatives. Therefore, this study utilizes the MAUT decision-making method for selecting the best biodegradable cutting fluid among a set of five (5) alternatives namely soybean oil, palm oil, polyalphaolefin, trimethylpropane trioleate and polyethylene glycol. The cutting fluids were evaluated based on criteria such as heat dissipation, stability, lubrication and cost-effectiveness. From the results, Polyalphaolefin is the best alternative, ranking first according to the global utility scoring. Therefore, Polyalphaolefin had a global utility score of 0.688, followed by Polyethylene Glycol which had a score of 0.600, followed by Trimethylpropane Trioleate which had a score of 0.588, followed by Soybean Oil which had a score of 0.363 and finally, Palm Oil which had a score of 0.263. This study provides a procedure for implementing the MAUT method of decision-making for cutting fluids selection within engineering workshops for sustainable machining practices.
P Perancangan Tata Letak Gudang Barang Jadi Produk Jilbab Dengan Metode Class Based Storage Dan Penataan Ergonomis CV Jilbab Surabaya
Authors: Mohamad Syihabul Akbar  
Published: June 2024

CV Jilbab Surabaya merupakan perusahaan yang membuat dan menjual Jilbab Segiempat, Jilbab Pashmina, Jilbab Bergo, dan lainnya. Gudang penyimpanan mempunyai dimensi dengan panjang 17 m, lebar 8m, dan tinggi 6 m. Mengetahui penyusunan layout usulan dengan metode class based storage, mengetahui waktu penataan produk, dan mengetahui dengan adanya investasi rak dan tenaga kerja menggunakan simulasi flexsim. Kegiatan kerja penelitian ini dilaksanakan selama 4 bulan dimulai pada tanggal 1 Oktober 2023 sampai dengan 31 Januari 2024. Dari hasil pengolahan klasifikasi ABC pada 20 jenis produk jilbab pada penyimpanan barang jadi pada CV Jilbab Surabaya : kelas A 68,92%, 26 produk, kelas B 14,72%, 8 produk, dan kelas C 16,09%, 11 produk. Pada layout usulan menggunakan flexsim didapatkan rata – rata waktu menunggu pada ketiga karyawan sebesar 7,07 detik dengan penataan barang yang tertata rapi dengan menggunakan metode class based storage.
Gemini Near Infrared Spectrograph−Distant Quasar Survey: Rest-frame Ultraviolet−Optical Spectral Properties of Broad Absorption Line Quasars
Authors: Ahmed Harum , Shemmer Ohad , Matthews Brandon , Dix Cooper , Ha Trung , Richards Gordon T. , Brotherton Michael S. , Myers Adam D. , Brandt W. N. , Gallagher Sarah C. , Green Richard , Lira Paulina , McLane Jacob N. , Plotkin Richard M. , Schneider Donald P. 
Published: June 2024

Abstract
We present the rest-frame ultraviolet−optical spectral properties of 65 broad absorption line (BAL) quasars from the Gemini Near Infrared Spectrograph−Distant Quasar Survey (GNIRS-DQS). These properties are compared with those of 195 non-BAL quasars from GNIRS-DQS in order to identify the drivers for the appearance of BALs in quasar spectra. In particular, we compare equivalent widths and velocity widths, as well as velocity offsets from systemic redshifts, of principal emission lines. In spite of the differences between their rest-frame ultraviolet spectra, we find that luminous BAL quasars are generally indistinguishable from their non-BAL counterparts in the rest-frame optical band at redshifts 1.55 ≲ z ≲ 3.50. We do not find any correlation between BAL trough properties and the Hβ-based supermassive black hole masses and normalized accretion rates in our sample. Considering the Sloan Digital Sky Survey quasar sample, which includes the GNIRS-DQS sample, we find that a monochromatic luminosity at rest-frame 2500 Å of ≳1045 erg s−1 is a necessary condition for launching BAL outflows in quasars. We compare our findings with other BAL quasar samples and discuss the roles that accretion rate and orientation play in the appearance of BAL troughs in quasar spectra.
En avoir le corps net
Authors: Chauliac Marina 
Published: June 2024

Partant d’une ethnographie des derniers bains-douches de Lyon, Grenoble et Saint-Étienne, cet article propose une réflexion sur les gestes et les espaces de lavage du corps dans un lieu d’hygiène collectif. Les douches publiques constituent en effet un poste d’observation privilégié pour accéder à ce qui relève en principe de l’espace privé, ce qui est généralement soustrait aux regards et qui semble aller de soi. Elles permettent dès lors d’appréhender les modalités de construction et de co-présence de normes sociales et culturelles en matière de propreté et d’intimité. Que signifient « se laver », ou encore « être propre » ? Que se passe-t-il lorsque les soins du corps sont contrôlés par une institution extérieure ? Comment s’amé­nager une « place » dans un lieu partagé ? Croisant dimension politique et ressentis des usa­gers et des employés, les bains-douches seront abordés comme révélateurs à la fois des politiques publiques d’hospitalité, de la pluralité et de la confrontation de règles et d’habitudes concernant les « techniques du corps », ainsi que des formes d’« invention du quotidien », où se bricolent et se négocient des temps et des espaces « à soi ».
Publicaciones autogestionadas feministas: haciendo feminismo a través de la práctica y cambiando la práctica a través del tiempo en la península ibérica
Authors: Casado Laura López 
Published: June 2024

Ces dernières années, les publications féministes autogérées, en particulier les fanzines, mais également les revues indépendantes ou les newsletters, ont connu un essor important. La façon dont ces publications naissent et se diffusent nous éclaire sur les féminismes ibériques, autogérés, axés sur la pensée collective, mais également sur l’usage des nouvelles technologies. La nature même de cet objet d’étude nous permet d’analyser les relations qui existent aux niveaux « translocal » et transnational, en utilisant l’ibérisme comme un nouvel angle d’approche.
Extrinsic tracheotomy tube compression in a patient with upper airway obstruction: A case series
Authors: Barter Lauren , Forner David , Munroe Kelti , Mukhida Karim , Brown Timothy , Massoud Emad 
Published: June 2024

ABSTRACT
Tracheostomies are commonly performed procedures for a variety of indications, including to secure a patient’s airway when endotracheal intubation is not advisable. Though routine, tracheostomies are not possible without complications. We present the first reported cases of patients with idiopathic external compression of a tracheostomy tube following a tracheostomy. In both cases, standard algorithms for the management of tracheostomy tube occlusion were followed. In both patients, subsequent inability to reinsert the cannula prompted bedside bronchoscopy. The first patient demonstrated a 40% to 50% occlusion of the tracheostomy tube as a result of the tube itself being compressed externally. The occlusion did not resolve, despite change of the entire tracheostomy tube, until a tracheal ring was excised. The second patient had a bronchoscopy at the bedside, revealing a 20% compression of the tracheostomy tube that was managed conservatively. There are several complications that can arise when performing a tracheostomy, but no previous cases have been published describing external compression of the tracheostomy tube.
Coexistence of Essential Thrombocythemia and Pituitary Adenoma: A Case Report of a Saudi Female Patient
Authors: Al-Ansari Rehab Yusuf , Al Otaibi Maha Jurais , Al-Ghamdi Amal Mohsen , Al-Zahrani Nada Rajab , Woodman Alexander 
Published: June 2024

Abstract:Essential thrombocythemia (ET) is a malignant hematological disease that has the ability to progress to acute leukemia or transform into other myeloproliferative neoplasms (MPNs). The coexistence of ET and other MPNs with pituitary adenoma (PA) is rare. There are no reports of cases of secretory PA of prolactin hormone in combination with ET. This case was reported in a young woman from Saudi Arabia who had the secretory PA present in combination with ET. The 20-year-old patient was treated for a micro-PA with hyperprolactinemia. The patient was referred to the hematological service for thrombocytosis. There was no history of thrombosis, cardiovascular risk factors, or constitutional symptoms. Laboratory tests showed that platelet levels consistently lagged from 700 × 103/µL to 1000 × 103/µL for 1 year. Hemoglobin 13 g/dL, white blood cells (WBCs) 6 × 103/µL, and normal WBC differential. The peripheral blood smear was inconclusive. A peripheral blood sample was sent for the cytogenetic study of myeloproliferative diseases, which came to be positive for c.1849G>T p.(V617F) mutation in the EXON 14 Janus kinase 2 (JAK2) gene. The patient was diagnosed with a MPN, ET with positive exon 14 JAK2, at low-risk category. Evidence suggests that MPNs in combination with endocrinological diseases are rare. However, there is a high incidence of MPN and unrelated tumors such as PA. Further research is recommended to thoroughly investigate endocrine tumors and look beyond secondary thrombocytosis that leads to thrombocythemia as in ET.