bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Oct1/Oct2-Deficiency on Cisplatin-Induced Changes in UrinaryN-Acetyl-β-D-Glucosaminidase
Authors: Franke Ryan M. , Kosloske Ashley M. , Lancaster Cynthia S. , Filipski Kelly K. , Hu Chaoxin , Zolk Oliver , Mathijssen Ron H. , Sparreboom Alex 
Published: July 2010

AbstractPurpose: This study aimed to test the influence of functional renal organic cation transporters (OCT2 in humans, Oct1 and Oct2 in mice) on biomarkers of cisplatin nephrotoxicity, such as urinary activity of N-acetyl-β-D-glucosaminidase (NAG).Experimental Design: Temporal cisplatin-induced nephrotoxicity was assessed by histopathology and biomarkers. Cisplatin-mediated NAG changes and survival were determined in wild-type and Oct1/2(-/-) mice. Identification of OCT2 inhibitors was done in transfected 293Flp-In cells, and the NCI60 cell line panel was used to assess contribution of OCT2 to cisplatin uptake in cancer cells.Results: Classical biomarkers such as blood urea nitrogen and serum creatinine were not elevated until 72 hours after cisplatin administration and substantial kidney damage had occurred. Oct1/2(-/-) mice had 2.9-fold lower NAG by 4 hours (P &lt; 0.0001) and 2.3-fold increased survival (P = 0.0097). Among 16 agents, cimetidine strongly inhibited uptake of tetraethylammonium bromide (P = 0.0006) and cisplatin (P &lt; 0.0001), but did not have an influence on cisplatin uptake in SK-OV-3 cells, the cancer line with the highest OCT2 mRNA levels. In wild-type mice, cimetidine inhibited cisplatin-induced NAG changes (P = 0.016 versus cisplatin alone) to a degree similar to that seen in Oct1/2(-/-) mice receiving cisplatin (P = 0.91). Cumulative NAG activity of &gt;0.4 absorbance units (AU) was associated with 21-fold increased odds for severe nephrotoxicity (P = 0.0017), which was linked with overall survival (hazard ratio, 8.1; 95% confidence interval, 2.1-31; P = 0.0078).Conclusions: Cimetidine is able to inhibit OCT2-mediated uptake of cisplatin in the kidney, and subsequently ameliorate nephrotoxicity likely with minimal effect on uptake in tumor cells. Clin Cancer Res; 16(16); 4198–206. ©2010 AACR.
Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F
Authors: Berkofsky-Fessler Windy , Buzzai Monica , Kim Marianne K-H. , Fruchtman Steven , Najfeld Vesna , Min Dong-Joon , Costa Fabricio F. , Bischof Jared M. , Soares Marcelo B. , McConnell Melanie Jane , Zhang Weijia , Levine Ross , Gilliland D. Gary , Calogero Raffaele , Licht Jonathan D. 
Published: July 2010

AbstractPurpose: To understand the changes in gene expression in polycythemia vera (PV) progenitor cells and their relationship to JAK2V617F.Experimental Design: Messenger RNA isolated from CD34+ cells from nine PV patients and normal controls was profiled using Affymetrix arrays. Gene expression change mediated by JAK2V617F was determined by profiling CD34+ cells transduced with the kinase and by analysis of leukemia cell lines harboring JAK2V617F, treated with an inhibitor.Results: A PV expression signature was enriched for genes involved in hematopoietic development, inflammatory responses, and cell proliferation. By quantitative reverse transcription-PCR, 23 genes were consistently deregulated in all patient samples. Several of these genes such as WT1 and KLF4 were regulated by JAK2, whereas others such as NFIB and EVI1 seemed to be deregulated in PV by a JAK2-independent mechanism. Using cell line models and comparing gene expression profiles of cell lines and PV CD34+ PV specimens, we have identified panels of 14 JAK2-dependent genes and 12 JAK2-independent genes. These two 14- and 12-gene sets could separate not only PV from normal CD34+ specimens, but also other MPN such as essential thrombocytosis and primary myelofibrosis from their normal counterparts.Conclusions: A subset of the aberrant gene expression in PV progenitor cells can be attributed to the action of the mutant kinase, but there remain a significant number of genes characteristic of the disease but deregulated by as yet unknown mechanisms. Genes deregulated in PV as a result of the action of JAK2V617F or independent of the kinase may represent other targets for therapy. Clin Cancer Res; 16(17); 4339–52. ©2010 AACR.
Children's Welfare in Soviet Russia: Society and the State, 1917-1930s
Authors: Smirnova Tatiana 
Published: July 2010

AbstractThe Bolsheviks did not alienate citizens from helping find solutions to the problems afflicting children. Many social actions deemed as "useful" by the Soviet authorities were met with support by the regime. These included the "Week of the Homeless Child", school self-taxation, local societies of the "Friend of the Children", and others. Establishing its control over "useful" public ventures, the Government eventually absorbed them. On the surface, the proliferation of public ventures in the area of children's welfare, such as patronage by industrial enterprises, labor unions and other groups and the growth of various advisory boards and children's inspections, appeared to be a result of growing social initiative. In reality the government's support of public work led to de facto state and party control. In order to carry out successful public initiatives, the population had to adapt to the particulars of Bolshevik rule.
The Constitutional Bases of Society and the Historical and Cultural Heritage of the Soviet Past in Modern Russia
Authors: Sokolov Andrey 
Published: July 2010

AbstractIn modern Russia problems of civil society's genesis discussed very widely. The author consecutively examines the social-cultural practices, which were generated by more then 70 years of Soviet history, and were reflected in low, constitutions and other legislative acts. He illustrated how these practices influenced the interaction between power and society, especially in labor and everyday Soviet life. The general attention was devoted to analysis of action of these practices after fall of Soviet system – how its may restrain or stimulate formation of civil society.
Molecular phylogeny and historical biogeography of the bee genus Colletes Latreille, 1802 (Hymenoptera: Apiformes: Colletidae), based on mitochondrial COI and nuclear 28S sequence data
Authors: Laurenne Nina , Almeida Eduardo , Quicke Donald , Kuhlmann Michael 
Published: July 2010

AbstractA phylogenetic analysis of the intrageneric relationships within the bee genus Colletes using a combined data set of the mitochondrial cytochrome oxidase 1 (COI) and 28S sequences is presented and its implications for historical biogeography are investigated. We analyzed 91 out of 469 described Colletes species (19.4%) from the entire range of distribution and 25 outgroup taxa representing all colletid subfamilies closely related to Colletinae. Eight different combinations of alignment parameters were used for the 28S data, and our combined data set comprised between 1801 and 1845 aligned nucleotides with COI contributing 339 informative bases and 28S between 318 and 360 informative sites. Our results corroborate the monophyly of about half of the Old World subgenera and show the need for a taxonomic re-delimitation of other groups currently accepted. The phylogenetic results confirm the South American origin of Colletes and multiple faunal exchange events between North America and Eurasia. The last continent colonized was Africa south of the Sahara, which experienced at least two independent invasions.
Salticidae (Arachnida: Araneae) from Oriental, Australian and Pacific Regions: Astilodes and Urogelides, new genera from Australia
Authors: Żabka Marek 
Published: July 2010

AbstractAstilodes mariae gen. et sp.n. and Urogelides daviesae gen. et sp.n. are diagnosed and described from eastern and south-eastern Queensland (Australia). Information on distribution and biota requirements for both generic type species are given. On the basis of morphological characters the genus Astilodes is temporarily classified within the Astioida clade, while Urogelides is placed in the Heliophaninae subfamily.
The Tibiotarsal Articulation and Intertibiotarsal Leg Sclerite in Dictyoptera (Insecta)
Authors: Schmidt Christian , Barton Ariane , Klass Klaus-Dieter , Eulitz Ute 
Published: July 2010

AbstractThe skeletal morphology of the transition area between the tibia and the tarsus is described for Dictyoptera, with a focus on Blaberus craniifer (Blattodea) and Sphodromantis viridis (Mantodea), but with 8 mantodean and 39 blattodean species (including 3 termite species) examined altogether. We emphasise the occurrence in most dictyopterans of a small sclerite located on the anteroventral side of the leg, between the margins of the tibia and the tarsus facing each other, the intertibiotarsal sclerite (abbreviated as itts: tibio-tarsal band/ligament sensu D. Neff and co-workers). The itts region is shown on SEM micrographs for a representative subset of our taxon sample. Comparison with selected outgroup species and data from the literature indicates that sclerite itts is autapomorphic for Dictyoptera and further confirms the monophyly of the group. Details of sclerite itts yield characters for phylogenetic work in Dictyoptera, such as a dorsal extension of the sclerite limited to a subset of our mantodean sample. In Cryptocercidae cockroaches and in termites sclerite itts is vestigial or absent, respectively. This could be interpreted as supporting termites to be the sister group of all remaining Dictyoptera, followed by Cryptocercidae. In the light of recent phylogenetic work, however, this rather appears to be a reductive apomorphy, which then further supports Cryptocercidae to be the sister group of termites. Functional aspects of the tibiotarsal articulation in Dictyoptera are also addressed, with a focus on the roles of and interdependence among the dorsal tibiotarsal articulation, the itts sclerite, and the tendons originating from the proximal rim of the tarsus (bearing the tarsal muscles); on this issue a functional model is presented. Most importantly, the effects of the tarsal muscles are being modulated with the status of itts (expanded or bent underneath).
A new tribe, genus and species of Nemonychidae from Baltic amber (Coleoptera: Curculionoidea: Nemonychidae: Cimberidinae)
Authors: Riedel Alexander 
Published: July 2010

AbstractA new tribe of Nemonychidae is proposed based on inclusions in Baltic amber: Kuschelomacerini trib.n., for Kuschelomacer kerneggeri gen. & sp.n. It can be attributed to the subfamily Cimberidinae but lacks some of the derived characters of the two extant tribes of this subfamily. The excellent preservation allows providing the most detailed description of a fossil Nemonychid weevil to date. Presumably, the species developed on Pinaceae common in the amber forests. Thus, the association of extant Cimberidinae with Pinaceae dates back at least until the Eocene.
The Bali Roadmap for Global Climate Policy—New Horizons and Old Pitfalls
Authors: Sterk Wolfgang , Watanabe Rie , Arens Christof , Mersmann Florian , Ott Hermann 
Published: July 2010

AbstractThe international climate negotiations have seen endless struggles between countries from South and North for almost 17 years, ever since the initiation of negotiations by the International Negotiation Committee (INC) for the United Nations Framework Convention on Climate Change (UNFCCC). The 13th meeting of the Conference of the Parties to the UNFCCC and the 3rd meeting of the Conference of the Parties serving as the meeting of the Parties to the Kyoto Protocol (COP 13 / CMP 3) held in Bali in December 2007 (the Bali conference) could mark the beginning of a rapprochement. Parties agreed on initiating a new “Ad-hoc working group on Long-Term Cooperative Action under the Convention” (AWG-LCA) that aims to negotiate a post-2012 agreement with participation of all parties, including the US and developing countries, by the end of 2009 at COP 15 / CMP 5 in Copenhagen. This article examines the outcomes of the Bali conference, focussing on the negotiations regarding post-2012, flexible mechanisms, financial mechanisms, technology transfer and deforestation. Finally, the article concludes that the Bali Conference saw a significant shift in the battle lines, a rearrangement of positions and alliances that might well announce a decisive new era in global climate policy and provides a real chance to agree on an effective and workable post-2012 agreement in Copenhagen.
The European Commission's proposed Directive on the geological storage of carbon dioxide
Authors: Tomescu Mihai , Brockett Scott , Doppelhammer Martina 
Published: July 2010

AbstractThe 2007 Spring European Council called for the European Union (EU) to be at the forefront of efforts to combat climate change and endorsed ambitious targets aimed at setting the European energy system on a sustainable path. To ensure that these targets are met, the European Commission put forward a set of proposed policy instruments, the Climate and Energy Package, in January 2008. A key element of the adopted Package is the proposed Directive on the geological storage of carbon dioxide, a technology which can help tackle emissions from energy generation from fossil fuel sources which will otherwise compromise EU climate objectives. This paper lays out policy options to incentivise the deployment of carbon dioxide capture and storage (CCS) in the EU and presents the proposed Directive.
Environmental judgments by the Court of Justice and their duration
Authors: Krämer Ludwig 
Published: July 2010

AbstractThis article discusses some data concerning the environmental jurisdiction of the EC Court of Justice during 2006 and 2007, and compares them with previous years. During this time, the Court—including the Court of First Instance—issued about one decision per week. The majority of cases concerned nature conservation issues, followed by waste and air-climate change matters. About two thirds of all cases were submitted to the Court by the European Commission. Preliminary cases (Article 234 EC Treaty) took, on average, a time of 19 months, cases under Article 230 21 months, and cases under Article 226 EC Treaty 18 months. However, if one includes in the cases under Article 226 the compulsory pre-judicial period, the average duration of procedures was 47 months, thus almost four years. A closer analysis of the data reveals that this long duration is mainly attributable to the EC Commission.
Perspectives for European Water Management Law Report of a conference in Brussels, 3 and 4 April 2008
Authors: Bach Simone 
Published: July 2010

AbstractOn 3rd and 4th April 2008 a conference containing the “Perspectives of European Water Management Law” took place in Brussels with participation of about 80 representatives of the European Commission and universities, authorities, enterprises and associations of the individual Member States of the European Community. The focus of the conference was on the Water Framework Directive 2000/60/EC and its implementation into national law, whereby the “polluter pays principle” arouse special interest. Another important and controversial topic was whether privatisation of the water sector would be advantageous or disadvantageous in regard to efficient allocation and sustainable environmental protection. Beyond the conference dealt with the public procurement in the water sector in relation to the directive 2004/17/EC, with the reorganisation of European protection against floods in the course of the EU flood directive 2007/60/EC and the effects of climate change on hydrologic balance.
Legal and design issues arising in linking the EU ETS with existing and emerging emissions trading schemes
Authors: Anderson Jason ,   Mace
Published: July 2010

AbstractSince the EU Emissions Trading Scheme (EU ETS) came into being in 2003, both the opportunity and incentive to link the EU ETS to other cap-and-trade schemes that aim to reduce greenhouse gases has increased dramatically. This paper provides an overview of the key design features of existing and emerging emissions trading schemes around the world. It then considers the political and technical significance of these design features for a decision on whether or not to link the EU ETS to these schemes and explores the possible legal nature of an agreement that could link various potential linking partners at the national and sub-national levels.
Cross-border Development Plans—An Outline of a Useful Planning Instrument for European Border Regions
Authors: Kment Martin 
Published: July 2010

AbstractThis article addresses the legal framework, the benefits and the difficulties of cross-border development plans. They will be presented by examining the advantages and disadvantages of two possible models with respect to a range of relevant criteria. The most important criteria are elements of procedural law, especially public participation; the preparation of planning regulations; the structure of the planning entity; and the implementation of templates into national legal systems. This analysis will point out, that the greatest obstacle to be overcome is assimilating the legal systems of the states involved—irrespective of which model is taken into account.
No wheels, no driver, can't travel. The EU sustainable consumption and production action plan, a framework of policies towards eco-design of products for material efficiency?
Authors: Shinn Melissa 
Published: July 2010

AbstractThe EU has a clear need to reduce its resource and material consumption to stay within biological and equitable limits. The EU Sustainable Consumption and Production and Sustainable Industry Policy Action Plan (SCP/SIP AP) published in 2008 is the new platform for development of policies on product eco-design and consumption. This article investigates the policies that could or do constitute drivers for product eco-design for material efficiency through various possible existing or foreseen policies. The scope includes the initiatives of the SCP/SIP AP itself and the various strategies and pieces of legislation that could be seen as part of the SCP legislative tool box, including the resources strategy, products and waste legislation. The underlying question is whether there is a comprehensive and effective sustainable consumption and production policy within the EU, and how far it goes.
Applying voluntary tools to achieve Sustainable Consumption and Production: collaboration between the European Commission and the retail sector
Authors: Aichinger Herbert , Schnabl Gernot , Parenti Alberto 
Published: July 2010

AbstractThis article analyses recent activities undertaken by the European Commission in collaboration with retailers and other stakeholders to help achieve sustainable consumption and production (SCP) as proposed in its SCP/SIP Action Plan. The focus is on the setting up and functioning of a Retail Forum. These activities are seen in the wider context of the use of “soft law” and, in particular, of voluntary environmental agreements as an effective alternative to regulatory measures in promoting sustainable development both along the supply chain and as regards consumers. The article suggests that the voluntary approach can be extremely useful to promote sustainable consumption and production provided that some essential conditions are met: voluntary commitments must be verifiable, they need the right level of ambition and they must involve a wide range of actors. In particular, the article explores the feasibility of developing a code of conduct for the retail sector.
'Gold plating' of European Environmental Measures?
Authors:   Squintani,   Aragão,   Macrory,   Jans,   Wegener
Published: July 2010

AbstractMinimum harmonization in European environmental law essentially means that the Member States have the power to lay down more stringent standards in this area of regulation than those laid down by European legislation. However, there were indications which seemed to suggest that Member States make very little use of their powers to lay down or maintain more stringent national standards. The general question to be dealt with in this paper is whether Member States actually use their power to lay down or maintain more stringent environmental standards after European harmonization. Based upon the papers and discussion at the meeting of the Avosetta Group of European Environmental Lawyers in Monção (Portugal), 6 and 7th February 2009, this paper aims to paint an impressionist picture of the contemporary practice of gold plating (or not) in the Member States.
Enforcing Non-Discrimination in Transboundary Environmental Impact Assessment: Advantages for EU Citizens from the Transposition of the Espoo and Aarhus Conventions?
Authors: Marsden Simon 
Published: July 2010

AbstractThis article examines the relationship between international and European law with respect to transboundary environmental impact assessment (TEIA), which under the UNECE Convention on Environmental Impact Assessment in a Transboundary Context (Espoo) applies requirements for EIA to the relationship between states known as 'Parties of origin' and 'affected Parties'. Information is shared and participation in the Party of origin procedure by the public in affected as well as origin states is required (non-discrimination); these provisions are enhanced under the related Convention on Access to Information, Public Participation in Decision-Making and Access to Justice in Environmental Matters (Aarhus), which also contains provisions enabling enforcement. The purpose is to analyse whether EU citizens have greater opportunities to enforce these rights than citizens of state Parties to the two treaties that are not members of the EU. Procedure and practice under the transposing directives on EIA and public participation is examined, and conclusions are drawn that although to a large extent EU membership is advantageous to EU citizens involved with TEIA, certain constraints concerning public participation and access to justice remain.
Climate change and EU legal initiatives regarding water availability
Authors: Krämer Ludwig 
Published: July 2010

AbstractDiscussions on climate change legislation concentrate on measures relating to the emission of greenhouse gases. The present contribution tries to have a look at the impact of water availability within the European Union and to examine the need for EU legislation in this area, starting from the fact that the EU has, until now, not considered water availability to be a topic which deserves specific attention by the Union. The articles points at the serious impact which water scarcity is likely to have in particular, though not exclusively, in Southern European countries and passes in review a number of possible options for EU wide legislation.
The environmental complaint in EU law
Authors: Krämer Ludwig 
Published: July 2010

AbstractThe European Commission which has a large discretion to decide which infringements of EC environmental law it will pursue, has recently published communications which announce that it will concentrate on the transposition of EC legislation into the law of the Member States. This omits to structurally address the practical application of environmental legislation. Strong environmental groups which could contribute to the effective application of EC environmental law, lack; this feature makes the environmental sector different from most other economic or social sectors, where strong interests—professional bodies, trade unions, competitors, trade and industry associations, farmers' associations—promote the defense of their respective interests. All the more is the environment dependent on the commitment of the civil society to preserve and protect it. The contribution examines the instrument of the environmental complaint in EU law and criticizes the Commission's attempt to stop using the complaint system as a tool to assess practical application of EC environmental law in the Member States, though it is almost the only one existing.