bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dithienocarbazole‐Based Ladder‐Type Heptacyclic Arenes with Silicon, Carbon, and Nitrogen Bridges: Synthesis, Molecular Properties, Field‐Effect Transistors, and Photovoltaic Applications
Authors: Wu Jhong‐Sian , Cheng Yen‐Ju , Lin Tai‐Yen , Chang Chih‐Yu , Shih Peng‐I. , Hsu Chain‐Shu 
Published: February 2012

AbstractA new class of ladder‐type dithienosilolo‐carbazole (DTSC), dithienopyrrolo‐carbazole (DTPC), and dithienocyclopenta‐carbazole (DTCC) units is developed in which two outer thiophene subunits are covalently fastened to the central 2,7‐carbazole cores by silicon, nitrogen, and carbon bridges, respectively. The heptacyclic multifused monomers are polymerized with the benzothiadiazole (BT) acceptor by palladium‐catalyzed cross‐coupling to afford three alternating donor‐acceptor copolymers poly(dithienosilolo‐carbazole‐alt‐benzothiadiazole) (PDTSCBT), poly(dithienocyclopenta‐carbazole‐alt‐benzothiadiazole) (PDTCCBT), and poly(dithienopyrrolo‐carbazole‐alt‐benzothiadiazole) (PDTPCBT). The silole units in DTSC possess electron‐accepting ability that lowers the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels of PDTSCBT, whereas stronger electron‐donating ability of the pyrrole moiety in DTPC increases the HOMO and LUMO energy levels of PDTPCBT. The optical bandgaps (Egopt) deduced from the absorption edges of thin film spectra are in the following order: PDTSCBT (1.83 eV) > PDTCCBT (1.64 eV) > PDTPCBT (1.50 eV). This result indicated that the donor strength of the heptacyclic arenes is in the order: DTPC > DTCC > DTSC. The devices based on PDTSCBT and PDTCCBT exhibited high hole mobilities of 0.073 and 0.110 cm2 V−1 s−1, respectively, which are among the highest performance from the OFET devices based on the amorphous donor‐acceptor copolymers. The bulk heterojunction photovoltaic device using PDTSCBT as the p‐type material delivered a promising efficiency of 5.2% with an enhanced open circuit voltage, Voc, of 0.82 V.
New Biomimetic Directions in Regenerative Ophthalmology
Authors: Green David W. , Watson Gregory S. , Watson Jolanta , Abraham Samuel J. K. 
Published: February 2012

AbstractOne of the most complete and permanent ways of treating many causes of visual impairment and blindness is to replace the entire affected tissue with pre‐cultured ocular tissues supported and maintained on biomaterial frameworks. One direction towards enhancing ocular tissue regeneration on biomaterials, in the laboratory is by applying biomimicry. Specifically to engineer biomaterials with important functional elements of the native extracellular matrices, such as topography, that support and organise cells into coherent tissues. Further problems in regenerative ophthalmology can be potentially solved through application of biomimicry. They include, more efficient ways of moving and transplanting cultivated tissues into correct therapeutic locations inside the eye and scar‐less, non‐destructive healing of surgical incisions and wounds, to repair structural integrity of tissues at the ocular surface. Two examples are given to show this potential for redeveloping an ocular epithelium onto a nanostructured insect wing surface and producing an origami membrane modelled on deployable structures in nature. Efforts to harness natural innovation will eventually provide unique designs and structures that cannot for now be made synthetically, for regeneration of clinically acceptable ocular tissues.
An update on pediatric bleeding disorders: Bleeding scores, benign joint hypermobility, and platelet function testing in the evaluation of the child with bleeding symptoms
Authors: O'Brien Sarah H. 
Published: February 2012

AbstractEvaluating a child with symptoms of easy bruising and/or bleeding remains a challenge in pediatric hematology, and there is no “one size fits all” approach. This review focuses on recent research in three elements of the evaluation of a child with a suspected bleeding disorder. We will first discuss the development of the standardized Pediatric Bleeding Questionnaire, and its applications in research and clinical settings. We will then discuss the relationship between benign hypermobility syndromes and hemostasis, and the importance of including a Beighton Score in the physical examination of any child presenting with unusual bruising or bleeding. While prolonged bleeding times and abnormal platelet aggregation are common findings in children with benign hypermobility, normal coagulation studies do not exclude the presence of a connective tissue disorder in a child presenting with easy bleeding and joint hypermobility on examination. Finally, we will discuss the current state of knowledge regarding the laboratory evaluation of platelet function in children. Platelet function disorders are among the most common inherited bleeding disorders. However, testing for such disorders is time‐consuming and requires a step‐wise approach. We will review the indications for and limitations of the most commonly utilized platelet function laboratory studies. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: A randomized, double‐blind placebo‐controlled cross‐over 4g study and an open‐label 8g extension study
Authors: Golombick Terry , Diamond Terrence H. , Manoharan Arumugam , Ramakrishna Rajeev 
Published: February 2012

AbstractMonoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) represent useful models for studying multiple myeloma precursor disease, and for developing early intervention strategies. Administering a 4g dose of curcumin, we performed a randomised, double‐blind placebo‐controlled cross‐over study, followed by an open‐label extension study using an 8g dose to assess the effect of curcumin on FLC response and bone turnover in patients with MGUS and SMM. 36 patients (19 MGUS and 17 SMM) were randomised into two groups: one received 4g curcumin and the other 4g placebo, crossing over at 3 months. At completion of the 4g arm, all patients were given the option of entering an open‐label, 8g dose extension study. Blood and urine samples were collected at specified intervals for specific marker analyses. Group values are expressed as mean ± 1 SD. Data from different time intervals within groups were compared using Student's paired t‐test. 25 patients completed the 4g cross‐over study and 18 the 8g extension study. Curcumin therapy decreased the free light‐chain ratio (rFLC), reduced the difference between clonal and nonclonal light‐chain (dFLC) and involved free light‐chain (iFLC). uDPYD, a marker of bone resorption, decreased in the curcumin arm and increased on the placebo arm. Serum creatinine levels tended to diminish on curcumin therapy. These findings suggest that curcumin might have the potential to slow the disease process in patients with MGUS and SMM. Am. J. Hematol. 87:455–460, 2012. © 2012 Wiley Periodicals, Inc.
The aging patient with hemophilia
Authors: Konkle Barbara A. 
Published: February 2012

AbstractThe prospects for many boys born with hemophilia today include a normal life expectancy and minimal to no joint disease. However, despite the availability of safe replacement clotting factor concentrates and effective antiviral treatment, the aging patient with hemophilia today faces many challenges. These include management of their hemophilia as well as the same age‐related health issues as experienced in the general population. While increasing, data on the prevalence of comorbidities and their management in the hemophilia population remain limited. This review will focus on issues related to management of hemophilia and complications of cardiovascular, musculoskeletal, hepatic, and renal disease. Available research is summarized and potential approaches to management are discussed. Am. J. Hematol. 2012. © 2012 Wiley Periodicals, Inc.
Enhanced photocatalytic performance of molecularly imprinted hydroxyapatite thin film for bilirubin degradation
Authors: Yang Zhengpeng , Zhang Chunjing 
Published: February 2012

ABSTRACTA molecularly imprinted hydroxyapatite (HAP) thin film was constructed onto the surface of quartz crystal using molecular imprinting and surface sol–gel process. Quartz crystal microbalance technique was employed to in situ investigate the interaction between bilirubin (BR) and HAP film. Compared with non‐imprinted HAP film, the molecularly imprinted HAP film not only exhibits a much higher adsorption capacity for BR molecule, but shows an enhanced photocatalytic activity in degrading BR. According to the in situ frequency measurement, the degradation‐rate constants (K) of BR on imprinted HAP film is about 8.05 × 10−4 s−1, which is two times higher than that obtained on non‐imprinted HAP film. © 2012 Curtin University of Technology and John Wiley & Sons, Ltd.
Gene expression analysis
Authors: Carvalho Felicia I. , Johns Christopher , Gillespie Marc E. 
Published: February 2012

AbstractGenome scale experiments routinely produce large data sets that require computational analysis, yet there are few student‐based labs that illustrate the design and execution of these experiments. In order for students to understand and participate in the genomic world, teaching labs must be available where students generate and analyze large data sets. We present a microarray‐based gene expression analysis experiment that is tailored for undergraduate students. The methods in this article describe an expression analysis experiment that can also be applied to CGH and SNP experiments. Factors such as technical difficulty, duration, cost, and availability of materials and equipments are considered in the lab design. The microarray teaching lab is performed in two sessions. The first is an introductory wet bench exercise that allows students to master the basic technical skills. The second builds on the concepts and skills with students acquiring and analyzing the microarray data. This lab exercise familiarizes students with large‐scale data experiments and introduces them to the initial analysis steps.
Development of a rapid UPLC‐MS/MS method for quantification of saxagliptin in rat plasma and application to pharmacokinetic study
Authors: Gao Jing‐wen , Yuan Yue‐mei , Lu Ya‐song , Yao Mei‐cun 
Published: February 2012

ABSTRACTA novel, simple and rapid ultraperformance liquid chromatography/tandem mass spectrometry (UPLC‐MS/MS) assay was established for quantification of saxagliptin in rat plasma. Plasma samples were processed by liquid–liquid extraction with ethyl acetate and chromatographed on a C18 column (2.1 × 50 mm i.d., 1.7 µm). The mobile phase consisted of methanol and 0.1% formic acid (40:60, v/v). Multiple reaction monitoring transitions were performed for detection in positive‐ion mode with an electrospray ionization source. The calibration curve was linear over the concentration range of 0.5–100 ng/mL (R2 > 0.99). All accuracy values were between 90.62 and 105.60% relative error and the intra‐ and inter‐day precisions were less than 9.66% relative standard deviation. Extraction recovery was more than 81.01% and the matrix effect ranged from 90.27 to 109.15%. After validation, the method was applied to a pharmacokinetic study where healthy rats were orally given 0.5 mg/kg saxagliptin. Copyright © 2012 John Wiley & Sons, Ltd.
Total Synthesis of Bafilomycin A1
Authors: Kleinbeck Florian , Fettes Gabriela J. , Fader Lee D. , Carreira Erick M. 
Published: February 2012

AbstractA convergent synthesis of bafilomycin A1, a potent inhibitor of V‐type ATPases, is presented. The synthesis relies on the zinc triflate mediated diastereoselective addition of a complex enyne to a sensitive aldehyde as the key fragment coupling. A ruthenium‐catalyzed trans‐reduction of the resulting propargylic enyne efficiently installs the required C10–C13 trans,trans‐diene subunit, implementing an alternative strategy to traditional palladium‐catalyzed cross‐coupling strategies. A highly selective oxidation of a secondary hydroxyl group in a triol sets the stage for the completion of the synthesis.
Triangular Nickel Complexes Derived from 2‐Pyridylcyanoxime: An Approach to the Magnetic Properties of the [Ni3(μ3‐OH){pyC(R)NO}3]2+ Core
Authors: Esteban Jordi , Ruiz Eliseo , Font‐Bardia Mercé , Calvet Teresa , Escuer Albert 
Published: February 2012

AbstractA series of nickel complexes with nuclearity ranging from Ni3 to Ni6 have been obtained by treatment of a variety of nickel salts with the 2‐pyridylcyanoxime ligand. The reported compounds have as a common structural feature the triangular arrangement of nickel cations bridged by a central μ3‐oxo/alkoxo ligand. These compounds are simultaneously the first nickel derivatives of the 2‐pyridylcyanoxime ligand and the first examples of isolated, μ3‐O triangular pyridyloximate nickel complexes. Magnetic measurements reveal antiferromagnetic interactions promoted by the μ3‐O and oximato superexchange pathways and comparison of the experimental structural and magnetic data with DFT calculations give an in‐depth explanation of the factors that determine the magnetic interaction in this kind of system.
Synthesis of Aldehyde‐Linked Nucleotides and DNA and Their Bioconjugations with Lysine and Peptides through Reductive Amination
Authors: Raindlová Veronika , Pohl Radek , Hocek Michal 
Published: February 2012

Abstract5‐(5‐Formylthienyl)‐, 5‐(4‐formylphenyl)‐ and 5‐(2‐fluoro‐5‐formylphenyl)cytosine 2′‐deoxyribonucleoside mono‐ (dCRMP) and triphosphates (dCRTP) were prepared by aqueous Suzuki–Miyaura cross‐coupling of 5‐iodocytosine nucleotides with the corresponding formylarylboronic acids. The dCRTPs were excellent substrates for DNA polymerases and were incorporated into DNA by primer extension or PCR. Reductive aminations of the model dCRMPs with lysine or lysine‐containing tripeptide were studied and optimized. In aqueous phosphate buffer (pH 6.7) the yields of the reductive aminations with tripeptide III were up to 25 %. Bioconjugation of an aldehyde‐containing DNA with a lysine‐containing tripeptide was achieved through reductive amination in yields of up to 90 % in aqueous phosphate buffer.
ChemInform Abstract: Crystal Structure of Na2MMgP2O8 (M: Ba, Sr, Ca) Orthophosphates and Their Luminescence Properties Activated by Eu2+; Analogous Structural Behaviors of Glaserite‐Type Phosphates and Silicates.
Authors: Yonesaki Yoshinori , Matsuda Chihiro 
Published: February 2012

AbstractThe title compounds are prepared by standard solid state reactions and characterized by powder XRD, Raman, and photoluminescence spectroscopy.
ChemInform Abstract: An Unprecedented Organic—Inorganic Hybrid Based on the First {Nb10V4O40(OH)2}12‐ Clusters and Copper Cations.
Authors: Huang Peng , Qin Chao , Wang Xin‐Long , Sun Chun‐Yi , Yang Guang‐Sheng , Shao Kui‐Zhan , Jiao Yan‐Qing , Zhou Kun , Su Zhong‐Min 
Published: February 2012

AbstractThe new compound {[Cu6(phen)6(H2O)3] [Nb10V4O40(OH)2]}2 ·13H2O is obtained from an aqueous mixture of K7HNb6O19, Cu(OAc)2, NaVO3, phen, and NaOH (pH 11.2, 58 °C, 8 h, 57% yield).
ChemInform Abstract: Mild and Efficient Trimethylsilylcyanation of Ketones Catalyzed by PNP Chloride.
Authors: Lacour Marie‐Agnes , Rahier Nicolas J. , Taillefer Marc 
Published: February 2012

AbstractTrimethylsilylcyanation of a wide range of aromatic and aliphatic ketones proceeds under solvent‐free conditions at room temperature using low amounts of bis(triphenylphosphoranylidene)ammonium chloride as organocatalyst.
ChemInform Abstract: Deacylative Allylation: Allylic Alkylation via Retro‐Claisen Activation.
Authors: Grenning Alexander J. , Tunge Jon A. 
Published: February 2012

AbstractThe reactions proceed via a retro‐Claisen rearrangement generating an allylic acetate and a carbanion which undergo Pd‐catalyzed C—C bond formation.
ChemInform Abstract: Ruthenium‐Catalyzed ortho‐Alkenylation of Aromatic Ketones with Alkenes by C—H Bond Activation.
Authors: Padala Kishor , Jeganmohan Masilamani 
Published: February 2012

AbstractA series of Heck‐type monoalkenylated products (III) is readily prepared with an excellent E‐stereoselectivity by a ruthenium‐catalyzed reaction of aryl ketones (I) with alkenes (II) in the presence of cupric acetate as oxidant.
ChemInform Abstract: Oxidative Iodination of Carbonyl Compounds Using Ammonium Iodide and Oxone®.
Authors: Reddy Marri Mahender , Kumar Macharla Arun , Swamy Peraka , Narender Nama 
Published: February 2012

AbstractA novel protocol for the selective α‐monoiodination of a variety of ketones and β‐keto ester is developed without the need for any metal or acid catalyst.
ChemInform Abstract: 1,8‐Diazabicyclo[5.4.0]undec‐7‐ene‐hydrobromide‐perbromide: An Oxidizing Agent for One‐Pot Oxidative Esterification of Aldehydes.
Authors: Jafari Aghdas , Bakavoli Mehdi , Pordel Mehdi 
Published: February 2012

AbstractAn efficient method for the esterification of aromatic and aliphatic aldehydes (I) with simple alcohols (II) is presented.
ChemInform Abstract: Successful Application of Indirect Electrooxidation for the Transformation of Biaryl Methanols to the Corresponding Biaryl Ketones.
Authors: Okimoto Mitsuhiro , Yoshida Takashi , Hoshi Masayuki , Chiba Tomohito , Maeo Kei 
Published: February 2012

AbstractOptimum reaction conditions are examined for the electrooxidation of biaryl methanols (I) to the corresponding ketones (II).
ChemInform Abstract: Facile Regioselective Synthesis of Functionalized Heterocycle‐Tethered Spiro Compounds via an Intramolecular Electrophilic Ipso‐Iodocyclization Process.
Authors: Majumdar K. C. , Ghosh Tapas , Shyam Pranab K. 
Published: February 2012

AbstractA general protocol for the intramolecular electrophilic ipso‐iodocyclization of phenylpropiolamides (I) and (IV) is designed to yield highly functionalized spiro compounds (III) and (V), respectively.
ChemInform Abstract: Synthesis of Pyrroles in Supercritical Carbon Dioxide: Formal [3 + 2] Cycloaddition of 2‐Benzoyl‐aziridines and Allenoates.
Authors: Cardoso Ana L. , Nunes Rui M. D. , Arnaut Luis G. , Pinho e Melo Teresa M. V. D. 
Published: February 2012

AbstractIn some cases, the process is more efficient if small amounts of MeCN are added as co‐solvent.
ChemInform Abstract: Synthesis of Novel Methylene Bridge Functionalized Bis(indolyl)methanes Thorough a Double Michael Addition.
Authors: Kargar Mojgan , Hekmatshoar Rahim , Mostashari AbdolJalil 
Published: February 2012

AbstractThe simple synthesis of novel bis(indolyl)methylmalonates based on an acid‐catalyzed double Michael addition is described.
ChemInform Abstract: Synthesis of New Bisphosphonate and Bisphosphonic Acid Derivatives and Heterocyclic and Dialkylcarbamoyl Oxazolone Derivatives with Anticancer and Antischistosomal Activity.
Authors: Boulos Leila S. , Ewies Ewies F. , Fahmy Amin F. M. 
Published: February 2012

AbstractThe reactions of 2‐aryl‐5(4H)‐oxazolones with phosphonates, phosphates, and tris(alkylamino)phosphines are studied and the underlying different reaction mechanisms are discussed.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Amido Linked Pyrrolyl and Pyrazolyl‐Oxazoles, Thiazoles and Imidazoles.
Authors: Padmavathi V. , Kumari C. Prema , Venkatesh B. C. , Padmaja A. 
Published: February 2012

AbstractThe title compounds (V), (VII) and (VIII) are obtained by 1,3‐dipolar cycloaddition of TosMic or diazomethane to the respective cinnamamide derivatives (III).
ChemInform Abstract: Synthesis of Thiazolyl Benzimidazoles and Thiazolyl Coumarins Linked to Isoxazole as Possible Biodynamic Agents.
Authors: Rajanarendar E. , Murthy K. Rama , Reddy M. Nagi , Shaik Firoz Pasha 
Published: February 2012

AbstractA new series of the title compounds is formed by cyclocondensation of isoxazole derivatives (I) with mercaptosuccinic acid followed by cyclization with diamines (VI) or salicylaldehydes (IV), respectively.
ChemInform Abstract: Multi‐Component Synthesis of 2‐Amino‐4H‐chromenes Catalyzed by Nano ZnO in Water.
Authors: Hosseini‐Sarvari Mona , Shafiee‐Haghighi Sara 
Published: February 2012

AbstractZinc oxide nanoparticles efficiently catalyze the three‐component condensation of aryl aldehydes with malononitrile and naphthols or phenols affording 2‐amino‐4H‐chromenes in good yields.
ChemInform Abstract: Efficient Synthesis and Free‐Radical Scavenging Capacity of New 2,4‐Substituted Tetrahydroquinolines Prepared via BiCl3‐Catalyzed Three‐Component Povarov Reaction, Using N‐Vinylamides.
Authors: Kouznetsov Vladimir V. , Gomez Carlos M. Melendez , Parada Luz K. Luna , Bermudez John H. , Mendez Leonor Y. Vargas , Acevedo Amner Munoz 
Published: February 2012

AbstractThe method is highly suitable for the library synthesis of novel cis‐tetrahydroquinolines with antioxidant properties.
ChemInform Abstract: A Convenient Synthesis of 4‐Alkoxy(or Aryloxy)‐3‐arylisoquinolin‐1(2H)‐ones from 2‐[Alkoxy(or Aryloxy)methyl]benzonitriles.
Authors: Kobayashi Kazuhiro , Matsumoto Kota , Kobayashi Akihiro , Tanmatsu Miyuki 
Published: February 2012

AbstractA two‐step sequence starting with aroylation of benzonitriles (I) and followed by hydrolytic cyclization provides a convenient method for the synthesis of title compounds (IV).
ChemInform Abstract: Convenient Synthesis of 2‐Aryl‐1‐haloindolizines from Pyridinium Salts and 2‐Aryl‐1,1‐dihaloalk‐1‐enes.
Authors: Yang Yiwen , Kuang Chunxiang , Jin Hui , Yang Qing 
Published: February 2012

AbstractA novel access is developed by 1,3‐dipolar cycloaddition of pyridinium salts with halo(aryl)alkynes generated in situ from 1,1‐dihaloalkenes and DBU.
ChemInform Abstract: Generation of Pyrrolo[2,1‐a]isoquinoline Derivatives from N‐Ylides: Synthetic Control and Structural Characterization.
Authors: Dumitrascu Florea , Caira Mino R. , Georgescu Emilian , Georgescu Florentina , Draghici Constantin , Popa Marcel Mirel 
Published: February 2012

AbstractNew pyrroloisoquinolines (III) are synthesized via 1,3‐dipolar cycloaddition between symmetrical acetylenic dipolarophiles (II) and isoquinolinium N‐ylides.
ChemInform Abstract: Expeditious Modular Assembly of Multisubstituted Cyclohexanes via Dioxanone—Dienes.
Authors: Aoki Yoshifumi , Mochizuki Yuta , Yoshinari Tomohiro , Ohmori Ken , Suzuki Keisuke 
Published: February 2012

AbstractAn effective one‐pot method for the title compounds (III) and (VII) is presented from the easily available alcohols (I).
ChemInform Abstract: p‐Sulfonic Acid Calixarenes as Efficient and Reusable Organocatalysts for the Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones/‐thiones.
Authors: da Silva Daniel L. , Fernandes Sergio A. , Sabino Adao A. , de Fatima Angelo 
Published: February 2012

AbstractAmong different calixarenes tested, CLX is found to be the most efficient one.
ChemInform Abstract: One‐Pot Synthesis of 1,2,3‐Triazole‐Linked Dihydropyrimidinones via Huisgen 1,3‐Dipolar/Biginelli Cycloaddition.
Authors: Salehi Peyman , Dabiri Minoo , Koohshari Majid , Movahed Siyavash Kazemi , Bararjanian Morteza 
Published: February 2012

AbstractThe synthesis of the biologically important heterocyclic scaffolds is accomplished via sequential 1,3‐dipolar cycloaddition of azides with propargylated benzaldehydes and Biginelli condensation of the resulting intermediate with urea and 1,3‐dicarbonyl compounds.
ChemInform Abstract: Convenient and Efficient Synthesis of Some Novel Fused Thieno Pyrimidines Using Gewald′s Reaction.
Authors: Nirogi Ramakrishna V. S. , Kambhampati Rama Sastri , Kothmirkar Prabhakar , Arepalli Sobhanadri , Pamuleti Narasimha Reddy G. , Shide Anil K. , Dubey P. K. 
Published: February 2012

AbstractNovel heterocyclic compounds, e.g. (X), (XV), and (XVII), are prepared by facile methods and screened for in vitro biological activity.
ChemInform Abstract: Synthesis of Highly Substituted 2,3‐Dihydropyrimido[4,5‐d]pyrimidin‐4(1H)‐ones from 4,6‐Dichloro‐5‐formylpyrimidine, Amines and Aldehydes.
Authors: Xiang Jinbao , Geng Chao , Yi Lang , Dang Qun , Bai Xu 
Published: February 2012

AbstractKey step in the synthesis of the title compounds is the cyclization of 4‐amino‐pyrimidine‐5‐carboxamides with aldehydes.