bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CT-based integrated model for preoperative prediction of occult lymph node metastasis in early tongue cancer
Authors: Han Wei , Wang Yingshu , Li Tao , Dong Yuke , Dang Yanwei , He Liang , Xu Lianfang , Zhou Yuhao , Li Yujie , Wang Xudong 
Published: April 2024

Background
Occult lymph node metastasis (OLNM) is an essential prognostic factor for early-stage tongue cancer (cT1-2N0M0) and a determinant of treatment decisions. Therefore, accurate prediction of OLNM can significantly impact the clinical management and outcomes of patients with tongue cancer. The aim of this study was to develop and validate a multiomics-based model to predict OLNM in patients with early-stage tongue cancer.

Methods
The data of 125 patients diagnosed with early-stage tongue cancer (cT1-2N0M0) who underwent primary surgical treatment and elective neck dissection were retrospectively analyzed. A total of 100 patients were randomly assigned to the training set and 25 to the test set. The preoperative contrast-enhanced computed tomography (CT) and clinical data on these patients were collected. Radiomics features were extracted from the primary tumor as the region of interest (ROI) on CT images, and correlation analysis and the least absolute shrinkage and selection operator (LASSO) method were used to identify the most relevant features. A support vector machine (SVM) classifier was constructed and compared with other machine learning algorithms. With the same method, a clinical model was built and the peri-tumoral and intra-tumoral images were selected as the input for the deep learning model. The stacking ensemble technique was used to combine the multiple models. The predictive performance of the integrated model was evaluated for accuracy, sensitivity, specificity, and the area under the receiver operating characteristic curve (AUC-ROC), and compared with expert assessment. Internal validation was performed using a stratified five-fold cross-validation approach.

Results
Of the 125 patients, 41 (32.8%) showed OLNM on postoperative pathological examination. The integrated model achieved higher predictive performance compared with the individual models, with an accuracy of 84%, a sensitivity of 100%, a specificity of 76.5%, and an AUC-ROC of 0.949 (95% CI [0.870–1.000]). In addition, the performance of the integrated model surpassed that of younger doctors and was comparable to the evaluation of experienced doctors.

Conclusions
The multiomics-based model can accurately predict OLNM in patients with early-stage tongue cancer, and may serve as a valuable decision-making tool to determine the appropriate treatment and avoid unnecessary neck surgery in patients without OLNM.
Echocardiographic findings in one case of Swyer‐James syndrome
Authors: Piovan M. , Sanson A. , Milani L. , Vallis G. 
Published: July 2009

AbstractThe Swyer‐James syndrome is an uncommon disease. The main finding is a hyperlucent lung with small hilar shadows on chest x‐ray. This is due to a decrease in pulmonary artery size at its origin and in the number and size of pulmonary branches. Pulmonary angiography is the standard method for diagnosis. We report a case of a unilateral hyperlucent lung in which the diagnosis was suggested by an echocardiographic evaluation.
Thrombolytic therapy in spontaneous coronary artery dissection
Authors: Behnam Ramsey , Tillinghast Stanley 
Published: July 2009

AbstractA 42‐year‐old female with no cardiac risk factors had an acute anterolateral myocardial infarction treated with intravenous (IV) tissue plasminogen activator (t‐PA). Selective coronary cineangiography a week later revealed extensive dissection of the left anterior descending coronary artery (LAD) and its second diagonal branch. Sixteen months later, she is asymptomatic. This is the fifth reported case of spontaneous coronary artery dissection treated with thrombolytic therapy during the acute event with uneventful recovery.
Diastolic pressure‐volume relationship during handgrip exercise in patients with coronary artery disease
Authors: Yoshikawa Tsutomu , Miyazaki Toshihisa , Akaishi Makoto , Ohnishi Showhei , Handa Shunnosuke , Nakamura Yoshiro 
Published: July 2009

AbstractThere is some controversy regarding the mechanisms of an upward shift in the left ventricular diastolic pressure‐volume curve during ischemia. The effects of handgrip exercise on the pressure‐volume curve were examined in 21 patients with coronary artery disease and in 6 control subjects. Pressure‐volume curves were constructed from digitized left ventricular pressure and volume derived from biplane left ventriculogram. Diastolic pressure‐volume curve shifted upward in 12 patients with coronary artery disease during handgrip exercise (Group 1), but not in the other 9 patients who were similarly afflicted (Group 2). The upward shift did not occur in any control subject. No difference was observed in rate‐pressure product gain during exercise. In Group 1, left ventricular end‐diastolic pressure increased (p<0.01) and ejection fraction was reduced (p<0.01), although it did not change in Group 2. In Group 1, the time constant was prolonged (p<0.01) with no change in the coefficient for elastic modulus. In Group 2, these parameters remained unchanged. Group 1 was accompanied by more extensive asynergy than Group 2. Thus, isometric handgrip exercise resulted in an upward shift in the diastolic pressure‐volume curve in patients with coronary artery disease. Incomplete relaxation and/or the viscoelastic properties of the left ventricle associated with ischemia could be responsible for this phenomenon.
Hyperhomocysteinemia and Endothelial Function in Young Subjects: Effects of Vitamin Supplementation
Authors: Hirsch Sandra , De La Maza M. Pia , Petermann Margarita M.Sc. , Barrera Gladys , Gattas Vivian , Escobar Edgardo , Yañez Paulina , Glasinovic Andrea , Bunout Daniel 
Published: July 2009

AbstractBackground: The relationship between hyperhomocysteinemia and cardiovascular disease has not been totally elucidated.Hypothesis: The study aimed to verify the association between hyperhomocysteinemia and endothelial dysfunction before and after modification of total homocysteine (tHcy) serum levels with vitamin supplementation in young male subjects devoid of any other cardiovascular risk factor.Methods: Twenty hyperhomocysteinemic (tHcy gt; 15 μmol/1) male volunteers (≤ 40 years) and 20 age‐matched subjects with normal tHcy levels (tHcy < 13 μmol/1) were included. Exclusion criteria were smoking, hypertension, diabetes, vitamin ingestion, obesity, hypercholesterolemia, renal failure, and positive antiphospholipid antibodies. Serum tHcy, folate, vitamin B12 levels, activated protein C and S, protein C resistance, fibrinogen, prothrombin, thrombin, antithrombin III, and in vitro oxidation of low‐density lipoprotein (LDL) particles were measured. Noninvasive ultrasound measurements of endothelium‐dependent (EDD) and ‐independent dilatation (EID) of the brachial artery were performed. Each pair was then randomly assigned to receive a vitamin capsule (0.6 mg folic acid, 0.8 mg B12, and 2.0 mg B6) or an identical placebo during 8 weeks, in a double‐blind study design. After the treatment phase, blood samples and vascular reactivity were repeated.Results: Nine pairs of volunteers received vitamins and 11 received placebo. Hyperhomocysteinemic subjects had lower baseline serum levels of vitamin B12. Serum folate levels, antithrombotic function, in vitro LDL oxidation, and EDD were similar in all groups. After the vitamin supplementation, serum folic acid levels increased significantly both in normo‐and hyperhomocysteinemic subjects, unlike vitamin B12, which increased only in the hyperhomocysteinemic individuals. Plasma tHcy decreased significantly in the supplemented groups. Treatment with vitamins was not associated with improvement in EDD or antithrombotic function.Conclusions: Mild hyperhomocysteinemia is not associated with endothelial dysfunction in young male subjects with no additional cardiovascular risk factors, and reduction of tHcy by vitamin supplementation does not modify EDD in this age group. In this sample, tHcy was more related to vitamin B12 than to folic acid status.
Assessment of Left Internal Mammary Artery Graft Patency by Transthoracic Doppler Echocardiography
Authors: El‐Masry Magdy M. , Salama Mai M. , Darwish Ahmed Z. , El‐Aziz Osama Abd 
Published: July 2009

AbstractBackground: The successful application of noninvasive Doppler spectrum analysis has been reported for the hemodynamic assessment of LIMA graft after myocardial revascularization.Hypothesis: The objective of this study was to assess the utility of transthoracic Doppler echocardiography (TTE) in providing information on LIMA flow in patients after coronary artery bypass graft surgery.Methods: In all, 22 patients (aged 62 ± 8 years) with LIMA graft to the left anterior descending (LAD) coronary artery who underwent coronary angiography were assessed using high‐frequency (5 MHz) transthoracic Doppler echocardiography. They were compared with 25 patients with angina (control group A, aged 59 ± 12 years), in whom an ungrafted LIMA was assessed, and with 17 patients (control group B, aged 59 ± 9 years) with angiographically normal coronary arteries, in whom the LAD was assessed.Results: A biphasic pattern (systolic and diastolic) was recorded in all cases. In 14 patients with a normal graft or < 70% stenosis (Group 1) and in control group B, blood flow was maximal during diastole. In eight patients with severe graft stenosis >70% (Group 2) and control group B, blood flow was maximal during systole, with low diastolic flow. The diastolic fraction of the velocity time integrals was 0.81 ± 0.11 for Group 1 and 0.25 ± 0.06 for Group 2 (p < 0.05). A diastolic velocity time integral fraction < 0.5 predicted gt; 70% stenosis with a sensitivity and specificity of 100%. The ratio of systolic/diastolic peak velocities was 0.61 ± 0.31 for Group 1 and 3.21 ± 0.49 for Group 2 (p<0.05). A systolic/diastolic peak velocity gt; 1 predicted stenosis >70% with a sensitivity and specificity of 100 and 90%, respectively.Conclusions: High‐frequency TTE is a useful noninvasive method for detecting LIMA graft blood flow. Severe graft stenoses exhibited Doppler velocity patterns, which were different from those of patent grafts, or grafts with moderate stenoses.
Quantification of Mitral Regurgitation by the Proximal Flow Convergence Method—Comparison of Transthoracic and Transesophageal Echocardiography
Authors: Grossmann Georg , Wöhrle Jochen , Kochs Matthias , Giesler Martin , Hombach Vinzenz , Höher Martin 
Published: July 2009

AbstractBackground: No data exist to indicate whether transthoracic (TTE) and transesophageal echocardiography (TEE) are of comparable value for the detection and quantification of mitral regurgitation using the proximal flow convergence method.Hypothesis: The study was performed to compare the value of TTE and TEE for the detection and quantification of mitral regurgitation using this method.Methods: The study included 57 patients with and 11 patients without mitral regurgitation. In all patients, the proximal flow convergence region was imaged by transthoracic and transesophageal color Doppler echocardiography, and proximal isovelocity surface area radii were determined. In 19 patients, monoplane TEE and in 49 patients multiplane TEE was performed. Thirty‐one patients with mitral regurgitation underwent cardiac catheterization.Results: Both methods had a comparable sensitivity for the detection of mitral regurgitation. Proximal isovelocity surface area radii derived from TTE and TEE agreed moderately (mean difference −0.5 ±1.3 mm). TTE and TEE correlated significantly with the angiographic grade (rank correlation coefficients 0.83 and 0.81), and both differentiated mild to moderate from severe mitral regurgitation with an accuracy of 90%. Regurgitant volumes derived from both echocardiographic techniques and cardiac catheterization correlated moderately (correlation coefficients between 0.67 and 0.81).Conclusions: TTE and TEE were of comparable value for the detection and quantification of mitral regurgitation using the proximal flow convergence method.
Signal‐Averaged P‐Wave Analysis of Normal Controls and Patients with Paroxysmal Atrial Fibrillation: A Study in Gender Differences, Age Dependence, and Reproducibility
Authors: Dhala Anwer , Underwood Donald , Leman Robert , Madu Ernest , Baugh Dainia , Ozawa Yukio , Kasamaki Yuji , Xue Qiuzhen , Reddy Shankara 
Published: July 2009

AbstractBackground: Atrial fibrillation is often first recognized after a complication such as embolic stroke has occurred. Limited data are available for the prospective identification of patients at risk for developing atrial fibrillation.Hypothesis: Demonstration of areas of slow conduction in the atrium by means of P‐wave signal averaging may identify individuals at risk for atrial fibrillation.Methods: P‐wave signal averaging from the surface electrocardiogram was performed in 199 normal controls and 81 patients with paroxysmal atrial fibrillation using an automated, P‐triggered, high‐resolution signal for analysis.Results: Of the variables measured, the filtered P‐wave duration and P‐wave integral were significantly different between controls and patients (filtered P‐wave duration 120 ± 9 vs. 145 ± 21 and P‐wave integral 666 ± 208 vs. 868 ± 352), whereas the terminal root‐mean‐square (RMS) voltages (RMS 20, RMS 30, RMS 40) showed no significant differences between the two groups. Regression analysis of the first and second measurement of the filtered P‐wave duration obtained during consecutive tests showed excellent reproducibility (r and r2 of 0.96 and 0.92). The duration of the filtered P wave showed no age dependence but was shorter in women.Conclusion: Utilizing the 90th percentile value of the filtered P‐wave duration of 13 3 ms in men and 13 0 ms in women, the sensitivity was 80 and 81%, the specificity 92 and 90%, the positive predictive value 84 and 73%, and the negative predictive value 90 and 93%, respectively.
Possible Relationship between Insulin Resistance and Remnant‐Like Lipoprotein Particles in Coronary Endothelial Dysfunction
Authors: Inoue Teruo , Uchida Toshihiko , Kamishirado Hirotoshi , Sakuma Masashi , Sakai Yoshihiko , Takayanagi Kan , Hayashi Terumi , Morooka Shigenori 
Published: July 2009

AbstractBackground: High insulin resistance and elevated remnant lipoprotein levels both correlate with impaired coronary vascular endothelial function. Hyperinsulinemia induces abnormalities of lipid metabolism. However, the correlation among insulin resistance, remnant lipoproteins, and endothelial function has not been clinically elucidated.Hypothesis: This study was designed to elucidate the correlation among insulin resistance, remnant lipoproteins, and acetylcholine (ACh)‐induced coronary artery response.Methods: Forty‐nine patients suspected of having ischemic heart disease, but without angiographically significant atherosclerotic coronary artery disease, underwent an ACh provocation test. Fasting venous blood was taken early in the morning on the day coronary angiography was performed. The insulin resistance index (IR) was determined from fasting plasma glucose and insulin concentrations, using the homeostasis model assessment (HOMA). Serum levels of remnant‐like lipoprotein particle cholesterol (RLP‐C) were measured.Results: Homeostasis model assessment IR was significantly higher (3.65 ±1.38 vs. 0.75 ± 0.14, p < 0.05) and log‐transformed HOMA (Log HOMA) was even more significantly higher (0.20 ± 0.12 vs. −0.29 ± 0.08, p< 0.001) in the ACh‐positive group (n = 23) than in the ACh‐negative group (n = 26). The serum RLP‐C level was also higher in the ACh‐positive group than in the ACh‐negative group (4.37 ± 0.63 vs. 2.52 ± 0.18 mg/dl, p<0.01). Log HOME and RLP‐C levels correlated with each other (R = 0.54, p < 0.001). Multiple regression analysis indicated that only the RLP‐C level was a dependent predictor of Log HOMA in various lipid profiles.Conclusions: Both high insulin resistance and elevated remnant lipoprotein levels correlated and might have a crucial role in the impairment of coronary vascular endothelial function, even in patients without angiographically significant coronary artery disease.
Comparative Experience of Open and Minimally Invasive Esophagogastric Resection
Authors: Parameswaran Rajeev , Veeramootoo Darmarajah , Krishnadas Rakesh , Cooper Martin , Berrisford Richard , Wajed Shahjehan 
Published: July 2009

AbstractBackgroundA minimally invasive approach to esophagogastric cancer resection offers an attractive alternative to traditional open surgery; however, concerns regarding feasibility, safety, cost, and outcomes have restricted widespread acceptance of these procedures. This study outlines our comparative experiences of both open and minimally invasive esophagectomy over a 4‐year period.MethodsSurgical outcomes were analyzed and compared between 30 consecutive patients who underwent open (Ivor Lewis) transthoracic esophagectomy (TTO) between January 2002 and December 2003 and 50 consecutive patients who underwent minimally invasive esophagectomy (MIO) from January 2004 to July 2006.ResultsInpatient mortality and overall surgical morbidity were identical for each cohort (TTO versus MIO: mortality 3% versus 2%; morbidity 50% versus 48%). Pulmonary‐related complications were higher in the open series (23% versus 8%; p = 0.05). The incidence of gastric‐conduit‐related complications was similar between the two cohorts (13% versus 18%; p = 0.52). Survival at 1 and 2 years was 86% and 58% in the TTO group and 94% and 74% in the MIO group. No significant difference in calculated cost was observed (£7,017 versus £7,885).ConclusionsTransition from open to minimally invasive techniques of esophagogastric resection for cancer is possible without compromising patient safety or incurring excessive financial expenses, and the minimally invasive procedure results in similar or potentially better outcomes.
Hollow Sodium Tungsten Bronze (Na0.15WO3) Nanospheres: Preparation, Characterization, and Their Adsorption Properties
Authors: Hou Jing , Zuo Guanke , Shen Guangxia , Guo H. e. , Liu Hui , Cheng Ping , Zhang Jingyan , Guo Shouwu 
Published: July 2009

Abstract
We report herein a facile method for the preparation of sodium tungsten bronzes hollow nanospheres using hydrogen gas bubbles as reactant for chemical reduction of tungstate to tungsten and as template for the formation of hollow nanospheres at the same time. The chemical composition and the crystalline state of the as-prepared hollow Na0.15WO3nanospheres were characterized complementarily, and the hollow structure formation mechanism was proposed. The hollow Na0.15WO3nanospheres showed large Brunauer–Emment–Teller specific area (33.8 m2 g−1), strong resistance to acids, and excellent ability to remove organic molecules such as dye and proteins from aqueous solutions. These illustrate that the hollow nanospheres of Na0.15WO3should be a useful adsorbent.
Nanocapsule for Safe and Effective Methane Storage
Authors: Suyetin MV , Vakhrushev AV 
Published: July 2009

Abstract
A nanocapsule for safe and effective methane storage is investigated by the method of molecular dynamics. The mass content of methane in the nanocapsule reaches the value of 14.5 mass%. The nanocapsule consists of two parts: a locking chamber and a storage area. The locking chamber is the nanotube (10.10), open at one end, with a K@C60
1+endohedral complex inside it. The storage area is a nanotube (20.20). The locking chamber and the storage area are joined with each other and form T-junction. The locking chamber is opened at the methane filling and the discharge stages, and it is closed at the storage stage. Thanks to the locking chamber, methane molecules are stored in the nanocapsules under normal external conditions. Opening and closing of the locking chamber are carried out by the K@C60
1+endohedral complex displacement, which is done by the electric field action. The specific structure of the nanocapsule allows two aims to be reached: a high methane mass content and significant level of safety.
Adsorption of Binary Mixtures of Anionic Surfactants at Water–Air and Poly(Tetrafluoroethylene)–Water Interfaces
Authors: Szymczyk Katarzyna , Jańczuk Bronisław 
Published: July 2009

AbstractMeasurements of the surface tension (γLV) and the advancing contact angle (θ) on poly(tetrafluoroethylene) (PTFE) were carried out for aqueous solutions of sodium decyl sulfate (SDS) and sodium dodecyl sulfate (SDDS) and their mixtures. The results obtained indicate that the values of the surface tension and the contact angle of solutions of surfactants on PTFE surface depend on the concentration and composition of the surfactants mixture. On the curves presenting the relationship between the surface tension, contact angle and monomer mole fraction of SDDS (α) in the mixture of SDDS and SDS, there is a minimum at α equal to 0.8 which together with the negative values of the interaction parameters indicate that synergism occurs in surface tension and contact angle reduction almost in the range of concentration corresponding to the saturated monolayer of surfactants at the water–air interface. The results and calculations obtained also indicate that for single surfactants and their mixtures at a given concentration in the bulk phase, the values of surface excess concentration of the surfactants at water–air and PTFE–water interfaces are nearly the same, which suggests that the orientation of SDDS and SDS molecules at both interfaces in saturated monolayer should be vertical to the interfaces. Taking into account the values of the monomer mole fractions of the surfactants in a mixed monolayer at the water–air interface and values of the contact angle of a single surfactant on the PTFE surface, it is possible in a simple way to predict the values of the contact angle of a mixture at a given concentration and composition.
An Isomeric Mixture of Novel Cerebrosides Isolated from Impatiens pritzellii Reduces Lipopolysaccharide‐Induced Release of IL‐18 from Human Peripheral Blood Mononuclear Cells
Authors: Zhou Xuefeng , Tang Lan , Liu Yonghong 
Published: July 2009

AbstractAn isomeric mixture of two cerebrosides, soya‐cerebrosides I and II, was isolated from an ethno drug, the rhizomes of Impatiens pritzellii Hook. f. var. hupehensis Hook. f., and their structures were identified by spectroscopic (NMR, MS) analysis. In order to determine the immunomodulatory activities of soya‐cerebrosides I and II, the effects of the mixture of cerebrosides (MC) on cytotoxicity of human peripheral blood mononuclear cells (PBMC) and the inhibitory activities to lipopolysaccharide (LPS)‐induced interleukin (IL)‐18 in PBMC were studied. The MC at concentrations of 10 and 1 μM, without toxicity to PBMC in 24 h, showed obvious inhibitory activity on IL‐18 secretion. Because of this effect of modulating the cellular immune response, soya‐cerebrosides I and II were considered to be the active substances of this ethno drug.