bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four‐year clinical outcome of sirolimus‐ and paclitaxel‐eluting stents compared to bare‐metal stents for the percutaneous treatment of stable coronary artery disease
Authors: Simsek Cihan , Onuma Yoshinobu , Magro Michael , de Boer Sanneke , Battes Linda , van Domburg Ron T. , Boersma Eric , Serruys Patrick W. ,   On Behalf of the Interventional Cardiologists of the Thoraxcenter (2000–2005)
Published: March 2010

AbstractBackground: There are limited data on the long‐term safety and efficacy profile of coronary stent implantation in patients with stable coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Objective: We aimed to assess the 4‐year clinical outcome in patients who received a bare‐metal stent (BMS), sirolimus‐eluting stent (SES), or a paclitaxel‐eluting stent (PES) for the percutaneous treatment of stable angina in our center during 2000–2005. Methods: In the study period, a total of 2,449 consecutive patients (BMS = 1,005; SES = 373; and PES = 1071) underwent a PCI as part of three historical PCI‐cohorts for stable angina and were routinely followed for the occurrence of major adverse cardiac events (MACE). Results: At 4 years follow‐up, 264 BMS patients (26.8%) had a MACE, compared to 75 SES patients (20.9%) and 199 PES patients (23.9%). Multivariate analysis showed that SES and PES were superior to BMS with respect to MACE [hazard ratio (HR) = 0.62, 95% confidence interval (CI): 0.47–0.81; HR = 0.67, 95% CI: 0.55–0.82, respectively]. The occurrence of MACE was significantly lower in the SES and PES population, primarily due to less target‐vessel revascularization (TVR) procedures (HR = 0.53, 95% CI: 0.37–0.75; HR = 0.71, 95% CI: 0.62–0.81, respectively). The occurrence of early, late, and very late stent thrombosis was equally rare with each stent type. There were no significant differences between SES and PES on death, myocardial infarction, TVR, and MACE. Conclusion: These findings suggest that SES and PES result in decreased TVR procedures and MACE compared to BMS at 4 years follow‐up. SES or PES implantation should be the preferred choice over BMS for patients with stable CAD undergoing PCI. © 2010 Wiley‐Liss, Inc.
The Light Transmission Method as a New Technique for Determining Flooding Characteristics in Gas‐Liquid Contactors
Authors: Babalona E. , Markopoulos J. 
Published: March 2010

AbstractIn gas‐liquid agitated vessels the flooding stage is generally used as a design criterion. The flooding stage is a characteristic dispersion stage which must be avoided in order to achieve efficient dispersion characteristics, while the identification of this flooding‐loading transition helps also determining the complete dispersion stage. Several methods have been applied for the determination of the flooding‐loading transition point. In this work, the light transmission method is used as a new technique for identification of this point in an air‐water dispersion system, agitated by a single six‐blade disc turbine. Using a relatively simple instrumentation, satisfactory results have been obtained. The method suggested is reliable, does not interfere with the fluid dynamics of the system, and is also applicable to nontransparent industrial reactors.
Verbund‐Simulation – Strategic Planning and Optimization of Integrated Production Networks
Authors: Viere T. , Brünner H. , Hedemann J. 
Published: March 2010

AbstractStrategic analysis and optimization of highly integrated production networks is an essential requirement for cost‐effective and resource‐efficient production. This paper presents a comprehensive software‐based concept for modeling, simulation, optimization, and visualization of an integrated silicone production network of Wacker Chemie AG. A Verbund‐Model was implemented in a step‐by‐step approach, starting with primary material streams in one business unit up to the modeling of all energy, waste, and cost streams in several business units. The system's flexibility enables different levels of detail for modeling processes and parts of the network: from simple input‐output relations to complex, nonlinear equations and specifications. The proactive implementation of technical measures and projects based on the assessment of future scenarios is an important outcome of the Verbund‐simulation.
Technical Feasibility of Electric Field Control for Turbulent Premixed Flames
Authors: Altendorfner F. , Beyrau F. , Leipertz A. , Hammer T. , Most D. , Lins G. , Branston D. W. 
Published: March 2010

AbstractThe utilization of electric fields for the control of technical combustion processes (EFCC, Electric Field Controlled Combustion) provides an interesting approach in present‐day discussions regarding reductions in CO2 emission levels and improved fuel efficiency. The technical feasibility of electric field control of turbulent premixed flames is demonstrated for the first time at technically relevant operating conditions. The technical criteria addressed include the efficiency of control at thermal powers above 50 kW, operating pressures in the order of 10 bar, air preheating, increased mixture exit velocities as well as swirl‐stabilized flames. Capacitive coupling of electric fields is explored against the background of preferably non‐intrusive integration into existing gas turbine systems. It is demonstrated that electric fields can be transmitted through ceramic burning chamber walls using capacitive coupling by electrodes deposited as coatings on the walls, thus avoiding sensitive mechanical parts as weak spots within the combustion chamber. No reasonable limitations are observed that might hinder a possible realization of flame control for technical combustion processes using EFCC.
Poly(arginine)‐Selective Coprecipitation Properties of Self‐Assembling Apoferritin and Its Tb3+ Complex: A New Luminescent Biotool for Sensing of Poly(arginine) and Its Protein Conjugates
Authors: Tsukube Hiroshi , Noda Yuki , Shinoda Satoshi 
Published: March 2010

AbstractThe apoferritin protein and apoferritin–Tb3+ complex were demonstrated to form oligomeric and polymeric self‐assemblies in neutral aqueous solutions, based on characterization by using luminescence and UV/Vis spectroscopy, dynamic light scattering, and transmission electron microscopy. Addition of a 20‐mer or higher poly(arginine) to the solution resulted in coprecipitation through nanoscale interactions, while biological proteins and other poly(amino acids) rarely yielded precipitates under the conditions employed. The apoferritin–Tb3+ complex assembly exhibited a particularly long‐lived green luminescence in aqueous solution, and its poly(arginine)‐selective precipitation behavior was followed by monitoring the changes in luminescence. The poly(arginine)‐tagged albumin precipitated selectively and quantitatively, so that the apoferritin–Tb3+ complex can function as a new luminescent biotool for the sensing of poly(arginine) and its protein conjugates.
Synthesis, Characterization, and Photophysical Properties of Materials Obtained by Co‐intercalation of Chromophores into Layered Double Hydroxides
Authors: Li Lei , Zhang Li , Wen Zheng , Chen Dazhou 
Published: March 2010

AbstractA pair of chromophores with donor‐acceptor properties, coumarin‐3‐carboxylic acid (3‐CCA) and 9‐anthracene carboxylic acid (9‐ACA), have been successfully intercalated into the layered double hydroxide (LDH), [Zn0.66Al0.34(OH)2](CO3)0.17·0.33H2O by an ion‐exchange method. The obtained co‐intercalation compounds were characterized by X‐ray diffraction, FTIR spectral, thermogravimetry techniques and chemical composition. The guest molecular sizes and structures were investigated utilizing an ab initio (HF/6‐31G) method by G98w. These anions were steadily arranged between the metal hydroxide layers by their carboxylate functional groups interacting with the layer plane. The photophysical properties of the obtained compounds were studied by UV‐Vis absorption and fluorescence spectroscopy. These results indicate that the confinement of the pair of chromophores, 3‐CCA and 9‐ACA, within the interlayer region of the host is in favor of guest‐host interaction and guest‐guest interaction, and that the pair of chromophores, 3‐CCA and 9‐ACA can give rise to energy transfer processes because of the characteristics of their excited states.
Estimation of Physico‐chemical Properties of Ionic Liquid EPReO4 Using Surface Tension and Density
Authors: Zang Shuliang , Fang Dawei , Yue Shuang , Li Jianxin , Wang Han 
Published: March 2010

AbstractAn ionic liquid (IL) EPReO4 (N‐ethylpyridinium rheniumate) was prepared. The density and surface tension values of the IL were determined in the temperature range of 293.15–343.15 K. The ionic volume and surface entropy of the IL were estimated by extrapolation, respectively. In terms of Glasser's theory, the standard molar entropy and lattice energy of the IL were estimated, respectively. Using Kabo's and Rebelo's methods, the molar enthalpy values of vaporization of the IL, ΔglH0m (298 K), at 298 K and, ΔglH0m (Tb), at hypothetical normal boiling point were estimated, respectively. According to the interstice model, the thermal expansion coefficient of IL EPReO4 (α) was calculated and compared with experimental value, finding their magnitude order is in good agreement by 8.98%.
Novel Porous Monolithic Column Using Poly(high internal phase emulsion) Methacrylate as Materials for Immunoglobulin Separation Performance on HPLC
Authors: Yang Jing , Yang Gengliang , Liu Haiyan , Bai Ligai , Zhang Qiaoxia 
Published: March 2010

AbstractA novel porous polymeric monolithic column based on poly(high internal phase emulsion) methacrylate monolith was prepared and applied to fast separation of proteins. The block copolymer chemistry of high internal phase emulsions was used in the experiment. These unique properties, together with high porosity, good mechanical property, chemical modification of the surface make themselves superior in monolithic medium applications. Morphology of the monolithic material was studied by scanning electron microscopy. The stability of the emulsion and the load of hydroxyl groups–the active group of the monolithic column were investigated. Additionally, the capabilities of separation of this column in conjunction with high performance liquid chromatography (HPLC) were investigated. Immunoglobulin was separated from human plasma and chicken egg yolk with high resolution on the hydrophobic interaction chromatographic column in a short time. The effects of pH and concentration of mobile phase (buffer) on the elution of immunoglobulin were investigated. Moreover, fast separation of a two mode protein mixture (α‐amylase and lysozyme) on the monolith was achieved within 1.5 min at a velocity of 1445 cm·h−1. As a result, good separation was achieved, and stable low back pressure drop was ensured at high throughput elution with an even longer column.
Synthesis and in vitro Antimicrobial Activity of New Ethyl 2‐(Ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐a]quinolin‐4‐yl)ethanoate Derivatives
Authors: Kategaonkar Amol H. , Sadaphal Sandip A. , Shelke Kiran F. , Kategaonkar Atul H. , Shingate Bapurao B. , Shingare Murlidhar S. 
Published: March 2010

AbstractA series of new ethyl 2‐(ethoxyphosphono)‐1‐cyano‐2‐(substituted tetrazolo[1,5‐a]quinolin‐4‐yl)ethanoate derivatives have been synthesized for the first time of tetrazolo[1,5‐a]quinoline derivatives. Elemental analysis, IR, 1H NMR, 13C NMR, 31P NMR and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram‐positive Bacillus subtilis, Gram‐negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity.
Design and Synthesis of Two Aromatic Amines with Dendritic Structure
Authors: Luo Zhenghong , Chen Hua , Xu Wei 
Published: March 2010

AbstractThe design and synthesis of two aromatic amines with dendritic structures, i.e. 3,4,5‐tribenzyloxyaniline (3,4,5‐G1‐NH2) and 2,5‐dibenzyloxyaniline (2,5‐G1‐NH2), were conducted. A coupling reaction of three or two equivalents of benzyl bromide to one equivalent of methyl hydroxybenzoate generated methyl 3,4,5‐tribenzyloxybenzoate (3,4,5‐G1‐COOCH3), methyl 2,5‐dibenzyloxybenzoate (2,5‐G1‐COOCH3) and 2,6‐dibenzyloxybenzoate (2,6‐G1‐COOCH3) in high yields. All G1‐COOCH3 derivatives were studied by X‐ray analysis. The results show that these dendrons have sufficient volume to be used as the fine ligands for certain catalysts. The amide intermediates (benzamide, G1‐CONH2) were obtained by reaction between ammonia and G1‐COOCH3. Interestingly, 2,6‐dibenzyloxybenzamide (2,6‐G1‐CONH2) can not be prepared in the same condition, which may be due to the overlarge steric block. Sodium hypochlorite was an effective oxidant to generate methyl carbamates G1‐ NHCO2CH3.
Efficient Synthesis of New Tetracyclic Benzofuro[3,2‐d]‐imidazo[1,2‐a]pyrimidine‐2,5‐(1H,3H)‐diones
Authors: Hu Yanggen , Liu Min , Ding Mingwu 
Published: March 2010

AbstractThe aza‐Wittig reaction of iminophosphorane (1) with aromaic isocyanates gave carbodiimides (2), which were allowed to react further with (‐amino ester in the presence of a catalytic amount of sodium ethoxide to give selectively new tetracyclic benzofuro[3,2‐d]imidazo[1,2‐a]pyrimidine‐2,5‐(1H,3H)‐diones (5) in good yields. X‐ray structure analysis of 5i verified the proposed structure and the reaction selectivity.
Vascular endothelial growth factor‐targeted therapy in metastatic renal cell carcinoma
Authors: Rini Brian I. 
Published: March 2010

AbstractInactivation of the von Hippel‐Lindau tumor suppressor gene in most sporadic renal cell carcinoma (RCC) tumors leads to a fundamental reliance on elements of this pathway, namely, the potent proangiogenic factor, vascular endothelial growth factor (VEGF). Thus, VEGF‐targeted therapeutics have undergone extensive clinical testing in RCC. Approaches to bind circulating VEGF protein (eg, bevacizumab) and small molecule inhibitors of the receptor on which the VEGF ligand binds (eg, sunitinib, sorafenib, axitinib, and pazopanib) have been tested. Robust clinical effects have been observed, including high objective response rates, prolonged progression‐free survival, and evidence of long overall survival for patients with metastatic RCC patients who are treated with these agents. Future directions include investigation of combination and sequenced therapy, elucidation of mechanisms of response and resistance, and exploration of the effect of these agents in other disease settings. Cancer 2009;115(10 suppl):2306‐12. © 2009 American Cancer Society.
Tissue biomarkers in renal cell carcinoma: Issues and solutions
Authors: Di Napoli Arianna , Signoretti Sabina 
Published: March 2010

AbstractRenal cell carcinoma (RCC) is an aggressive malignancy that is associated with a high rate of metastasis. Although several promising therapeutic strategies are now available for the treatment of patients with metastatic kidney cancer, the prognosis of these patients remains poor. Research is ongoing to identify RCC‐specific biomarkers that can improve early diagnosis, surveillance of tumor progression, and prediction of patient prognosis. The identification of biomarkers that may predict response to specific therapies also will be useful in stratifying patients with RCC for treatment selection. Unfortunately, biomarker detection and measurement in kidney tumor tissues can be biased significantly by the lack of standardization in tissue sample acquisition, storage, and analysis. Consequently, the establishment of standardized operating procedures is necessary to maximize the accuracy of tissue‐based biomarker assays. Herein, the authors discuss current issues in tissue‐based translational research aimed at identifying clinically useful biomarkers for kidney cancer. Cancer 2009;115(10 suppl):2290‐7. © 2009 American Cancer Society.
American Society of Clinical Oncology‐recommended surveillance and physician specialty among long‐term breast cancer survivors
Authors: Hollowell Kerry , Olmsted Courtney L. , Richardson Anne S. , Pittman H. Keith , Bellin Lisa , Tafra Lorraine , Verbanac Kathryn M. 
Published: March 2010

AbstractBACKGROUND:It is unclear whether it is appropriate to transfer the follow‐up care of breast cancer (BrCa) survivors from cancer specialists to primary care physicians (PCPs). This contemporary study compared physician specialty and documented the long‐term surveillance of survivors who underwent surgery at an American academic center.METHODS:Women in this institutional review board‐approved study underwent breast surgery between 1996 and 2006. Data were collected for 270 patients with stage I to III BrCa (mean follow‐up, 6 years). Charts were reviewed based on American Society of Clinical Oncology (ASCO) guidelines for recommended surveillance frequency and care.RESULTS:The majority of patients (90%; n = 242) were followed by specialists with 10% (n = 28) followed by PCPs. Patients with advanced disease and a greater risk of disease recurrence more often received specialist care. Patients followed by specialists were more often seen at ASCO‐recommended intervals (eg, 89% vs 69% of patients followed by a PCP at follow‐up Year 6; P < .01); however, many patients were followed inconsistently. Breast disease was often not the focus of PCP visits or mentioned in clinic notes (18% patients). Women seen by specialists were more likely to have documented clinical examinations of the breast (93% vs 44% at Year 6), axilla (94% vs 52%), or annual mammograms (74% vs 48%; P = .001‐.02).CONCLUSIONS:Consistent compliance with surveillance guidelines and chart documentation needs improvement among all providers; however, specialists more consistently met ASCO guidelines. If transfer of care to a PCP occurs, it should be formalized and include follow‐up recommendations and defined physician responsibilities. Providers and patients should be educated regarding surveillance care and current guidelines incorporated into standard clinical practice. Cancer 2010. © 2010 American Cancer Society.
Interdiffusion phenomena in InGaAs/GaAs superlattice structures
Authors: Sarıkavak B. , Öztürk M. K. , Mammadov T. S. , Özçelik S. 
Published: March 2010

AbstractWe have studied structural properties of InGaAs/GaAs superlattice sample prepared by Molecular Beam Epitaxy (MBE) using high resolution X‐ray diffractometer (HRXRD). Increasing strain relaxation and defect generations are observed with the increasing Rapid Thermal Annealing (RTA) temperature up to 775 °C. The higher temperatures bring out relaxation mechanisms; interdiffusion and favored migration. The defect structure and the defects which are observed with the increasing annealing temperature were analyzed. Firstly, the in‐plane and out‐of‐plane strains after the annealing of sample were found. Secondly, the structural defect properties such as the parallel X‐ray strain, perpendicular X‐ray strain, misfit, degree of relaxation, x composition, tilt angles and dislocation that are obtained from X‐ray diffraction (XRD) analysis were carried out at every temperature. As a result, we observed that the asymmetric peaks especially in asymmetric (224) plane was affected more than symmetric and asymmetric planes with lower polar or inclination angles due to c‐direction at low temperature. These structural properties exhibit different unfavorable behaviors for every reflection direction at the increasing temperatures. The reason is the relaxation which is caused by spatially inhomogeneous strain distribution with the increasing annealing temperature. In the InGaAs superlattice samples, this process enhances preferential migration of In atoms along the growth direction. Further increase in the annealing temperature leads to the deterioration of the abrupt interfaces in the superlattice and degradation in its structural properties. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A conformance test tool for next generation network applications and systems
Authors: Yang Shun‐Ren , Leong Chon‐Wang 
Published: March 2010

AbstractThis paper describes the architecture and operations of a test system NGNAS‐SIOTP. NGNAS‐SIOTP is designed based on the Testing and Test Control Notation Version 3 (TTCN‐3) specifications for the conformance testing of next generation network applications and systems. By specifying conformance test cases in abstract level, the test cases are language and platform‐independent, and the implementation of the test cases can be more convenient. We use an Open Mobile Alliance (OMA) Browsing test case of XHTML Structure Module and an IP Multimedia Subsystem (IMS) test case of Replaces Extension Header Field to illustrate how conformance tests can be implemented and conducted in our NGNAS‐SIOTP. These test cases conform to the OMA Enabler Test Specification (Conformance) for OMA Browsing and RFC documents for IMS. Copyright © 2010 John Wiley & Sons, Ltd.
Melanocytic bronchopulmonary carcinoid tumor in a patient with multiple endocrine neoplasia syndrome type 1: A case report with emphasis on intraoperative cytological findings
Authors: Matsuda Kant M. , Nóbrega Raíssa , Quezado Martha , Schrump David S. , Filie Armando C. 
Published: March 2010

AbstractWe present the cytological features along with histologic and imaging findings of a melanocytic bronchopulmonary carcinoid tumor in a patient with multiple endocrine neoplasia syndrome type 1 (MEN‐1). Intraoperative touch preparations of the lung tumor showed single spindle cells and loosely cohesive aggregates of spindle cells with oval to elongated nuclei, “salt and pepper” chromatin pattern and inconspicuous nucleoli. The spindle cells occasionally contained cytoplasmic pigment, which revealed to be melanin by Fontana Masson stain on permanent processed material. Immunohistochemical stains for both synaptophysin and chromogranin were strongly positive in the spindle cells. The findings were consistent with melanocytic bronchopulmonary carcinoid tumor, which is relatively uncommon in MEN‐1. Diagn. Cytopathol. 2010;38:669–674. © 2009 Wiley‐Liss, Inc.
Putting pubertal timing in developmental context: Implications for prevention
Authors: Graber Julia A. , Nichols Tracy R. , Brooks‐Gunn Jeanne 
Published: March 2010

AbstractThis article examines selected findings regarding the consequences of difference in timing of pubertal onset in order to build an explanatory model of puberty in context. We also seek to shed light on possible prevention efforts targeting adolescent risk. To date, there is substantial evidence supporting early onset effects on both internalizing and externalizing problems during the adolescent decade and possibly beyond. However, such effects do not directly speak to preventive intervention. The biological, familial, and broader relationship contexts of puberty are considered along with unique contexts for early maturing girls versus boys. Finally, we identify potential strategies for intervention based on these explanatory models. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 254–262, 2010