bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strides in Care Management: The Development of a Framework to Facilitate Quality Outcomes
Authors: Adams-Best Linda 
Published: July 2010

Care Management has been in existence for years. The thrust of the role is to monitor, evaluate and enhance resource utilization while maintaining quality of care. The pivotal assumption being through enhanced patient flow, and coordinated services with appropriate resource utilization, better patient outcomes are achieved. During times of fiscal restraint, quality may become a secondary concern. This paper presents a framework to assist Care Managers, and administrators, in achieving desired outcomes that embrace fiscal accountability and quality patient care. Donabedian's model1 and Systems theory2,3 are the foundations for this framework.
Recommandations sur la gestion de la fermeture d'un hôpital
Authors: van der Wal Rena , Bouthillette France , Havlovic Stephen J. 
Published: July 2010

Le ministère de la Santé de la Colombie-Britannique a fermé un hôpital de soins aigus en 1993. On a mené une étude sur les façons dont cette fermeture a touché les employés de l'hôpital pour déterminer des moyens de faciliter le processus de fermeture et de réorganisation. On a interviewé en privé 25 employés au moment de la fermeture et six mois plus tard. Six thèmes se sont dégagés de l'analyse qualitative dans la catégorie « vivre la fermeture ». Ces thèmes sont: (1) la communication de l'information, (2) l'effet de la fermeture sur le milieu de travail et sur les collègues, (3) le stress perçu, (4) la reconnaissance de sa propre valeur, (5) la prestation de services de soutien et (6) le processus d'avoir un nouvel emploi. Les auteurs off rent des recommandations émanant de cette analyse pour aider d'autres person nes à planilier les futures réorganisations ou fermetures d'hôpitaux.
High-fat diet results in postprandial insulin resistance that involves parasympathetic dysfunction
Authors: Afonso Ricardo A. , Lautt W. Wayne , Schafer Josh , Legare Dallas J. , Oliveira Antonio G. , Macedo M. Paula 
Published: July 2010

Different diets have distinct impacts on glucose homoeostasis, for which insulin sensitivity (IS) after a meal (postprandial IS) is highly relevant. Postprandial IS depends upon hepatic parasympathetic activation and glutathione content elevation. We tested the hypothesis that postprandial IS is compromised in high-fat diet (HFD)-induced obesity. Sprague–Dawley rats were fed a standard diet (STD, n 10), 1-week HFD (n 9) or 4-week HFD (n 8). IS was tested in postprandial state using the rapid IS test (RIST) before and after the blockade of the parasympathetic nerves (atropine, 1 mg/kg); parasympathetic-dependent IS was obtained from the difference between control and post-atropine RIST. Fasting IS was also assessed in the STD-fed rats (n 4) and 4-week HFD-fed rats (n 3) using the RIST. Whole-body fat and regional fat pads were heavier in the 1-week HFD-fed rats (79·8 (se 7·9) and 23·7 (se 1·0) g, respectively) or 4-week HFD-fed rats (106·5 (se 6·1) and 30·1 (se 1·4) g, respectively) than in the STD-fed rats (32·5 (se 3·7) and 13·7 (se 1·0) g, respectively; P < 0·001). Fasted-state IS was similar between the groups studied. Postprandial IS was higher in the STD-fed rats (185·8 (se 5·6) mg glucose/kg body weight (bw)) than in both the 1-week HFD-fed rats (108·8 (se 2·9) mg glucose/kg bw; P < 0·001) and 4-week HFD-fed rats (69·3 (se 2·6) mg glucose/kg bw; P < 0·001). Parasympathetic-dependent IS was impaired in both HFD-fed groups (STD, 108·9 (se 3·9) mg glucose/kg bw; 1-week HFD, 38·6 (se 4·2) mg glucose/kg bw; 4-week HFD, 5·4 (se 1·7) mg glucose/kg bw; P < 0·001). Total (postprandial) and parasympathetic-dependent IS correlated negatively with whole-body fat (R2 0·81 and 0·87) and regional adiposity (R2 0·85 and 0·79). In conclusion, fat accumulation induced by HFD is associated with postprandial insulin resistance, but not with fasting insulin resistance. HFD-associated postprandial insulin resistance is largely mediated by impairment of parasympathetic-dependent insulin action, which correlates with adiposity.
Toward scientifically useful quantitative models of psychopathology: The importance of a comparative approach
Authors: Krueger Robert F. , DeYoung Colin G. , Markon Kristian E. 
Published: June 2010

AbstractCramer et al. articulate a novel perspective on comorbidity. However, their network models must be compared with more parsimonious latent variable models before conclusions can be drawn about network models as plausible accounts of comorbidity. Latent variable models have proven generative in studying psychopathology and its external correlates, and we doubt network models will prove as useful for psychopathology research.
Quality-adjusted life expectancy benefits of laparoscopic bariatric surgery: A United States perspective
Authors: Hernandez Lyndon V. , Klyve Dominic 
Published: June 2010

Objectives: The method of choice for bariatric surgery remains controversial. The aim of this study was to compare the outcome of laparoscopic Roux-en-Y gastric bypass (L-RYGB) versus laparoscopic adjustable gastric banding (LAGB) using quality-adjusted life-years (QALYs).Methods: We developed a Markov model of the quality of life and survival of L-RYGB and LAGB in obese patients. Using census data, we estimated the probability of dying and quality of life for each year of each cohort.Results: For all cohorts, L-RYGB offers the highest advantage in QALYs compared with gastric banding. The youngest cohort showed the greatest discrepancy between the two surgical methods, with 7.8, 6.4, and 4.7 QALYs gained with L-RYGB over LAGB for the age groups 35, 45, and 55, respectively. Those with the highest presurgical body mass index (BMI) acquired the most advantage with L-RYGB, with 2.8, 6.4, and 9.6 QALYs gained with L-RYGB over LAGB for the BMI groups 40, 50, and 60. Males had a slightly higher advantage with L-RYGB, with 6.5 QALYs gained with L-RYGB over LAGB compared with 6.0 QALYs for females.Conclusions: For the cohorts studied, L-RYGB is the preferred surgical treatment for obesity if the sole metric is QALYs. The young and extremely obese are core groups who will gain the most QALYs following L-RYGB.
On the socio-economic determinants of antenatal care utilization in Azerbaijan: evidence and policy implications for reforms
Authors: Habibov Nazim N. 
Published: July 2010

AbstractAzerbaijan is a country with one of the highest child mortality rates in the regions of Eastern Europe and the former Soviet Union. Drawing on the nationally representative Demographic and Health Survey, this study examines the utilization of antenatal care in Azerbaijan to identify the socio-economic determinants of the usage, and its frequency, timing and quality. Consequently, binomial logit, two ordered logit and negative binomial regression models are specified to estimate the effect of various socio-economic characteristics on the likelihood of utilization. Place of living is an important determinant of antenatal healthcare utilization in Azerbaijan. It is important in determining the likelihood of utilization, its timing and quality of care received, whereas it is not significant in the model predicting the frequency of antenatal utilization. Women’s education is also significant in three models out of four. Education is important in explaining the frequency and timing of utilization as well as the quality of services received, but it is not significant in predicting the likelihood of utilization. Wealth gradient is another important determinant of antenatal care utilization in Azerbaijan inasmuch as it is significant in explaining the likelihood of prenatal care utilization and its frequency. In addition, two variables, birth order and desirability of the last child or current pregnancy, are significant only in explaining the likelihood of utilization. Therefore, we confirm the findings of previous studies, which reported that the utilization of prenatal health care is a multistage process in which decisions are sequential. Although the same set of factors may affect decision-making at all stages, the effect of these factors is different at different stages. Implications for reforms in the healthcare sector to improve antenatal care utilization in Azerbaijan are provided and discussed.
Ibuprofen augments pro‐inflammatory cytokine release in a mouse model of Vibrio vulnificus infection
Authors: Lee Yuarn‐Jang , Chuang Yin‐Ching 
Published: June 2010

ABSTRACTWe evaluated the effects of ibuprofen on cytokine production and mortality in a mouse model of septic shock induced by Vibrio vulnificus, strain Chi Mei Vv05191. Ibuprofen (50 mg/kg) or saline (control) was given to female BALB/cByJ mice for three consecutive days before exposure to the pathogen. For cytokine production, serum and peritoneal fluid were assayed for IL‐1β, IL‐6, TNF‐α, and MIP‐2 by ELISA at 3, 6, and 9 hr after intraperitoneal infection of the organism. At 6 hr after infection, serum and peritoneal fluid levels of IL‐6, TNF‐α, and MIP‐2 were significantly higher in the ibuprofen group. For mortality determination, 73 mice (37 ibuprofen, 36 control) were injected intramuscularly with V. vulnificus. Kaplan–Meier survival curves were analyzed. Survival was significantly decreased by ibuprofen only for the lowest inoculum (25 CFU) of V. vulnificus. Administration of ibuprofen before infection may augment the pathogenesis of V. vulnificus by stimulating cytokine production.
Inhibition of CD23‐dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules
Authors: Pree I. , Shamji M. H. , Kimber I. , Valenta R. , Durham S. R. , Niederberger V. 
Published: June 2010

SummaryBackground
Vaccination with hypoallergenic recombinant Bet v 1 derivatives (Bet v 1 fragments and Bet v 1 trimer) is associated with the induction of IgG antibodies specific to natural Bet v 1.Objective
To investigate whether IgG antibodies induced following vaccination with genetically modified hypoallergenic Bet v 1 derivatives are able to inhibit IgE‐facilitated binding of allergen‐IgE complexes to B cells.Methods
Sera from 46 patients obtained before and after subcutaneous vaccination with Bet v 1 trimer (n=14), Bet v 1 fragments (n=11) or placebo (n=21) were incubated with recombinant (r) Bet v 1 and an indicator serum (IS) from a birch pollen‐allergic patient with high CD23 binding capacity. Bet v 1 immune complexes were added to a CD23‐expressing B cell line and co‐operative binding of Bet v1‐IgE complexes to CD23 was measured with a polyclonal anti‐IgE FITC antibody using a bio‐functional cellular flow cytometric assay.Results
When sera from patients vaccinated with rBet v 1 derivatives were incubated with Bet v 1 and the IS, a reduction of IgE binding to CD23 was observed. This effect was not seen when sera from placebo‐treated patients were used. The decrease in CD23/IgE binding was statistically significant in the trimer group [pre‐ vs. post‐specific immunotherapy (SIT): P=0.02; trimer vs. placebo: P<0.04] but not in the Bet v 1 fragments‐treated group. Trimer‐treated patients had higher levels of Bet v 1‐specific IgG than fragment‐treated patients. The degree of inhibitory activity of IgE‐facilitated allergen binding correlated with Bet v 1‐specific IgG levels following SIT (R=0.492; P=0.012).Conclusion
Vaccination with both recombinant Bet v 1 derivatives induces Bet v 1‐specific IgG antibodies, which are able to inhibit the co‐operative binding of allergen‐IgE complexes to CD23, and may thereby reduce allergen‐specific T cell responses. Cite this as: I. Pree, M. H. Shamji, I. Kimber, R. Valenta, S. R. Durham and V. Niederberger, Clinical & Experimental Allergy, 2010 (40) 1346–1352.
Cutaneous signs of liver disease: value for prognosis of severe fibrosis and cirrhosis
Authors: Niederau Claus , Lange Stefan , Frühauf Martin , Thiel Andreas 
Published: July 2010

AbstractBackground/Aims: Although physicians have looked for cutaneous signs of liver disease for more than a century, their prognostic value has never been evaluated systematically.Methods: Therefore, cutaneous changes were prospectively recorded in all patients referred for liver biopsy from June 2000 to May 2004. Fibrosis was staged from F0 to F4 according to Desmet and Scheuer. The analysis included 744 patients, 520 of whom had chronic hepatitis C while the remaining had other diseases.Results: By univariate analysis, the frequency of several skin changes was associated with the degree of fibrosis. In general, at fibrosis F0–1 skin changes were infrequent; they became more frequent at F2 and were frequent at F3–4. To analyse the predictive value of skin changes, patients with fibrosis F0–2 were compared with those with F3–4. Final logistic regression included spider naevi, palmar erythema, teleangiectasia, bleeding signs and dry skin as well as age and gender. When routine laboratory values were included in the analysis, prothrombine time, γ‐glutamyltransferase and albumin proved to be significant. Receiver operating characteristic (ROC) showed a good discrimination of fibrosis F0–2 from F3–4 by the modelled score on combining skin changes and laboratory tests: at the cost of 2% of non‐diagnosed patients with F3–4, one might have saved 60% of biopsies. ROC was less useful in discriminating fibrosis F0–1 from F2–4. The discriminative power of skin changes was better than the laboratory values and the aspartate aminotransferase/platelet ratio.Conclusions: The results prove that it is quite useful to look for skin changes in patients with liver disease.
Light Regulation to Chlorophyll Synthesis and Plastid Development of the Chlorophyll‐Less Golden‐Leaf Privet
Authors: Yuan Ming , Xu Mo‐Yun , Yuan Shu , Chen Yang‐Er , Du Jun‐Bo , Xu Fei , Zhang Zhong‐Wei , Guo Zi‐Chan , Zhao Zhong‐Yi , Lin Hong‐Hui 
Published: June 2010

Abstract
Ligustrum vicaryi L. is a hybrid of Ligustrum ovalifolium Hassk. var. aureo‐marginatum and Ligustrum vulgale L., and displays a chlorophyll‐less phenotype. Therefore it is widely used as a horticultural shrub because of its golden‐color leaves. Its putative mechanism, light responses, chlorophyll synthesis and plastid development were studied. L. vicaryi has a higher level of 5‐aminolevulinic acid (ALA), but lower levels of chlorophylls compared with L. quihoui. The yellowish phenotype of L. vicaryi upper leaves could be attributed to their hampered conversion from chlorophyllide into chlorophyll a. Despite the enhanced ALA level and the decreased thylakoid stacking in plastids, L. vicaryi golden leaves contain normal levels of Lhcb transcripts and photosystem apoproteins. Furthermore, reactive oxygen species (ROS) accumulation is almost the same in L. vicaryi and L. quihoui. The golden leaves often turn green and the contents of chlorophylls increase with decreasing light intensity. Dynamic changes of chlorophyll‐synthesis‐system under the light transition were also analyzed.
Intravitreal ranibizumab for macular oedema secondary to retinal vein occlusion: a retrospective study of 34 eyes
Authors: Puche Nathalie , Glacet Agnès , Mimoun Gérard , Zourdani Alain , Coscas Gabriel , Soubrane Gisèle 
Published: June 2010

Abstract.Purpose:  To evaluate the efficacy and the safety of intravitreal ranibizumab injection (Lucentis) in eyes with macular oedema secondary to central retinal vein occlusion (CRVO) or branch retinal vein occlusion (BRVO).Methods:  The files of consecutive patients (34 eyes, 15 CRVO, 19 BRVO) were retrospectively analysed. Intravitreal injections of 0.5 mg ranibizumab were administered; retreatment was based on acuity visual changes and optical coherence tomography findings. Patients received 2–4 injections (mean, 2.1). Mean follow‐up was 7 months.Results:  After the first injection, mean best‐corrected visual acuity (BCVA) improved from 20/160 to 20/80 and mean central retinal thickness (CRT) decreased significantly from 549 to 301 μm (p < 0.01). For each injection, BCVA improvement was on average nine letters (p < 0.01) and macular oedema reduction was 195 μm CRT (p < 0.01). The decrease in CRT was similar in CRVO and BRVO, but the improvement in BCVA was larger in BRVO. No local or systemic adverse effect was detected. Final visual acuity was correlated to initial visual acuity and to visual acuity measured after the first injection. The change in CRT was correlated to the number of injections and to initial CRT.Conclusion:  Intravitreal injections of ranibizumab appeared to be a safe and effective option in the treatment of macular oedema secondary to retinal vein occlusion. Nevertheless, because the natural course has demonstrated a possible improvement in vision in almost one quarter of affected eyes at 3 years, further controlled and prospective studies are necessary to compare this treatment to the natural course with a longer follow‐up.
Het Trefwoord 'Holland': Opschudding Over Een Artikel in De Real-Encyklopädie (1856)
Authors: Broeyer F.G.M. 
Published: July 2010

AbstractIn 1856 the sixth volume of the editio princeps of the famous German encyclopedia Real-Encyklopädie für protestantische Theologie und Kirche was published. The volume included a lengthy article on the history and present situation of the Dutch Reformed Church and other protestant churches in the Netherlands. A reformed minister of Frankfurt am Main, Carl (or Karl) Sudhoff, was the author. His article provoked a fierce protest. A Dutch ministers' association demanded from the editor, the Erlangen professor J.J. Herzog, a new article that put right what they regarded as errors. Herzog was not very inclined to comply, for it is hardly common practice to enter critical supplements in an encyclopedia. Finally, however, he gave way. The Leyden professor J.J. Prins wrote an article with a mass of criticism and after the endorsement of the ministers' association this was sent to Erlangen. Those discontented men then fell into a rage again. There was indeed a supplement to the article on Holland at the end of the eighth volume of the Real-Encyklopädie, but it did not offer the text of Prins. Herzog had added his own commentary to Prins's review. Time and again he remarked that the severe criticism sent from Holland was the criticism of a party. Besides that it turned out that he had omitted many important matters in the critical review written by Prins. The point at issue was that the very orthodox Sudhoff gave a highly biased description of the history and contemporary situation of Dutch Protestantism. Already in 1851 many people in Holland were angry about Abraham Capadose's report on the Netherlands at the meeting of the Evangelical Alliance in London. The orthodox agreed with what men like Capadose said in other countries, but followers of other parties in the Dutch protestant churches wanted a balanced and more appreciative judgement of their position. All parties were keen on an image matching their own viewpoints. The reason why they were doing so much to correct a negative image elsewhere was the interest in their identity. In 1860 all that thinking about identity led to two brilliant treatises on Dutch Protestantism in the nineteenth century: Chr. Sepp's Proeve eener pragmatische geschiedenis der Theologie hier te lande and D. Chantepie de la Saussaye's La Crise religieuse en Hollande.
Lodewijk De Vrome's Openbare Boetedoening in 833: Een Kwestie Van Ministeria
Authors: Oberndorff Theo 
Published: July 2010

AbstractThis article intends to support the thesis that the eleventh-century investiture controversy was preceded by a similar struggle between Church and State in the Carolingian era. In the ninth century already, some bishops, convinced by a theological principle, stood up for the unity of Christianity and within this constellation for the superiority of episcopal power. At the deposition and public penance of Louis the Pious in 833, such considerations played a very important part. The growth of this episcopal self-awareness is indicated by the slowly evolving interpretation of episcopal responsibility (ministerium) in the Frankish secular and ecclesiastical legislation from the sixth to the ninth century. The disagreement among the Carolingian episcopate about the legitimacy of Louis' deposition, however, resulted in a stalemate during which the former emperor regained control.
Eentfoldich End Kortt Discours Van Henlegginge Der Huiden Riligionssverschillen, So Hier Alss Anders-Swaer in Der Evangelische Christenheitt Van Langerhandt40 Erressen
Authors: Van Der Pol F. 
Published: July 2010

AbstractThe archives of the town of Kampen in Overijssel (the Netherlands) contain an early 17th-century manuscript by an unknown author. The manuscript is about an ecclesiastical conflict in the period preceding the Synod of Dort (1618-1619). The document might be related to peace efforts as also made by Hugo Grotius in the dispute between Remonstrants and Contraremonstrants. The author does not aim at a doctrinal decision or strict definition, but at accommodation and tolerance. The idea of an evangelical-Lutheran contribution to solve the party conflict in order to reach a conciliation between Lutherans and Reformed also strikes one as 'Grotiaans'. Another feature which makes this document look like the efforts of Grotius is the link between political and ecclesiastical peace. People should accept each other as citizens, despite their religious differences. The document contains a couple of indications which provide a profile of the author. This profile is applied to the border province of Overijssel, with concentration on the town of Kampen. The author may have been the headmaster of a Latin School. In 1617, this school in Kampen was run by Marcus Gualtherus, a scholar from Weinheim in the Lower Palatinate, near Heidelberg. He studied at Heidelberg. His scholarship, his Palatine origin, his many-sided contacts, all this corresponds with features of the treatise. The author shows familiarity with theological issues within the Lutheran Church in Germany. In his proposal, the five articles of the Remonstrants should be approached with the help of the Palatine experience. The writer of the treatise refers to the 16th-century Lutheran creeds and reformers like Luther, Bucer and Zwingli. He indicates the important role of the CA in achieving unity among Lutherans in Germany. This confession is quoted repeatedly as a model for the Protestants in the Netherlands. At the synod a final draft could be formulated with the aid of the Book of Concord. A final text might be endorsed by all evangelical churches. With the acceptance of this document upon which all parties agree, a general concordia of the whole of evangelical Christendom will have been established.