bluuebunny/crossref_metadata_2025_split huggingface dataset:
GATA genotype and FY*B(-67T>C) polymorphism as a cheap and reliable tool to evaluate ethnicity in Brazilian patients submitted to autologous transplantation
Authors: Tucunduva Luciana , Dinardo Carla Luana , Otuyama Leonardo Jun , Chinoca Ziza Karen , Arrais Rodrigues Celso , Novis Yana , Figueiredo Costa Silvia , Rocha Vanderson 
Published: May 2024

Abstract

Collecting high quality data on race and ethnicity is crucial for clinical research, notably in genetic association studies, to avoid confounding by different ethnic background among patients, a bias referred to as population stratification. In Brazil, to describe race we commonly use the National Institute of Geography and Statistics (IBGE) classification, so-called “self-declared color”, but it is acknowledged that defining ancestry by phenotypic characteristics, especially in countries with highly mixed population like Brazil, can be misleading. We aimed to evaluate the relationship between the GATA FY*B(-67T>C) polymorphism and self-declared race in Brazilian patients undergoing autologous transplantation and verify the feasibility of using this test as a more reliable tool to evaluate ethnicity in this population. Methods: We conducted a study to evaluate the association of candidate-gene polymorphisms and toxicities after autologous stem-cell transplantation (ASCT) in adult patients with lymphoma or myeloma from 2015 to 2021 in two Brazilian transplant centers. All patients with available DNA to study genetic polymorphisms were included. In this analysis we evaluate the association between GATA polymorphism and self-declared color in this cohort. Results: A total of 217 patients were included in this analysis. Median age at transplantation was 56 years (21-79) and 130 patients (59.9%) were male. Most patients were self-declared white (n=175, 80.6%) and the most common genotype was GATA67T/T (wild type/wild type) (n=142, 65.4%). Among the self-declared white patients, 73.1% were genotyped as GATA67T/T and 4.0% as GATA-67C/C, while among the non-white patients 21.4% were genotyped as GATA-67C/C (p<.001). The allele FY*B(-67T>C) frequency was 0.22 in the whole population; it was identified in 26.9% of the self-declared white patients and in 66.6% of the non-white (p<.001). Twelve-month overall survival was 86.6% (95% CI 79.9 - 91.2%), with no difference according to self-declared race (86.8% vs 85.5% for white and non-white patients, respectively, p=0.81) or the presence of the allele FY*B(-67T>C) (85.2% vs 89.9% for non-mutated and mutated patients, respectively, p=0.27). Conclusion: GATA FY*B(-67T>C) polymorphism is associated to self-declared race in Brazilian patients submitted to ASCT. Given the importance of correctly evaluating ancestry in genetic association studies in transplantation, GATA FY*B(-67T>C) polymorphism can be used as a more accurate tool in populations with mixed ethnic/racial background.
FLT3-MUTATED ACUTE MYELOID LEUKEMIA OUTCOMES IN A NORTHEAST BRAZILIAN UNIVERSITY HOSPITAL
Authors: Amorim Mota Segundo Hercules , Facundo de Alencar Araripe Lara , Magalhães Chaves Ana Vitoria , Mariano de Alencar Paulo Henrique , Barroso Duarte Fernando 
Published: May 2024

Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene occur in approximately 25-45% of new diagnoses of Acute myeloid leukemia. The addition of FLT3 inhibitors to conventional protocols improves overall survival in this condition. Objectives: To assess the incidence of FLT3 gene mutation among patients diagnosed with AML at Walter Cantídio University Hospital; Describe access to FLT3 inhibitors and bone marrow transplantation (BMT), and the overall survival of this group. Methodology: Retrospective evaluation of medical records of patients treated for AML between 2020 and 2022. Statistical analysis was performed using the Kaplan-Meier method to estimate survival probability. Results: 47 patients were diagnosed with AML during this period, of whom 17% had FLT3+ mutation. 3/8 patients accessed FLT3 inhibitors. The median survival with FLT3+ mutation was 9.1 months vs. 12.9 months in FLT3- (p = 0.196). The overall survival of AML patients was 30.9% at 2 years. 11/47 patients underwent allogeneic BMT. Conclusion: The addition of targeted therapies and BMT may contribute to reduce mortality in AML. Elderly patients and those not undergoing HSCT have worse outcomes.
Moderasi Beragama dalam Bingkai Teologis: Respon Terhadap Konflik Politik Berbasis Agama di Indonesia
Authors: Nego Obet , Pasang Agustina 
Published: May 2024

Political activities in Indonesia are often marred by feuds and horizontal conflicts. This is caused by the misuse of religious identity for the benefit of various groups and political parties. This paper aims to reveal the importance of religious moderation in the frame of Christian theology applied in the context of politics in Indonesia, as well as identify political conflicts with religious backgrounds that are considered very dangerous and threaten the integrity of the nation. This research uses a qualitative method, namely library research with a Christian theology approach as its main reference, of course, literacy is relevant to the research problem. The results show various challenges of religious moderation in politics in Indonesia, the theological basis of religious moderation, and theological values in religious moderation. In conclusion, applying religious moderation in a theological frame can avoid political conflicts with a religious background.Kegiatan berpolitik di Indonesia kerap kali dicederai oleh perseteruan dan konflik horizontal. Hal tersebut diakibatkan oleh penyalahgunaan identitas agama demi berbagai kepentingan kelompok maupun partai politik. Tulisan ini bertujuan untuk mengungkapkan pentingnya moderasi beragama dalam bingkai teologi Kristen yang diterapkan di dalam konteks berpolitik di Indonesia, serta mengidentifikasi konflik politik yang berlatar belakang agama yang dinilai sangat berbahaya dan mengancam keutuhan bangsa. Penelitian ini menggunakan metode kualitatif, yaitu library research dengan pendekatan systematic theology sebagai rujukan utamanya, tentunya literasi-literasi tersebut relevan dengan permasalahan penelitian. Hasil penelitian menunjukkan berbagai tantangan moderasi beragama dalam politik di Indonesia, Dasar teologis moderasi beragama, dan Nilai-nilai teologis dalam moderasi beragama. Kesimpulannya, dengan menerapkan moderasi beragama dalam bingkai teologis dapat menghindari konflik-konflik politik yang berlatar agama.
Teenage Pregnancy and its Impact on Learners: Perceptions of Educators in Rural UMkhanyakude District, South Africa and Implications for Action
Authors: Ndlovu Thandiwe Sylvia , Qwab Bongani Reginald , Ojogiwa Oluwaseun Temitope 
Published: May 2024

In many low and middle-income nations around the world, teen pregnancy and its effects are a serious public health issue. The soaring rate of teenage pregnancy has attracted voluminous efforts and strategies by the South African government, which is yet to produce a satisfactory modification to the prevailing status. In realisation of the possible consequences of teenage pregnancy to learners, their parents and the nation, this study examines the factors responsible for the soaring rate and the effect of teenage pregnancy on the learners from the perception of educators in UMkhanyakude District, which is one among the poorest district municipalities. Qualitative research technique that generates non-numeric data was employed to gather comprehensive viewpoints. Fifteen teachers were purposefully selected and interviewed using a semi-structured interview. Retrieved data were synthesised and distilled into themes. It was found that teen pregnancy could be influenced by different factors, and it has become a great concern for educators. Also, the incidences of unwanted pregnancy have different effects on the learners and the educators’ performance. As a result, the ability of educators to deal with pregnant students and provide them with individualised attention suffers. The data demonstrate that teenage pregnancy is a serious problem that requires the attention of many community members. Teenage pregnancy in a learning environment is a source of worry for teachers who are unprepared to handle the changing behaviours of pregnant teenagers at school. Thus, this study offers some recommendations for the efficient prevention of teenage pregnancy and especially to reduce its impact on teenagers’ education.
Material Planning Analysis with Material Requirement Planning Method in High-rise Building Projects
Authors: Awati Mawinda Oktrify , Putra I Nyoman Dita Pahang 
Published: May 2024

Planning material supplies well is very important in implementing construction projects to ensure smoothness and efficiency. Smoothness includes thorough planning, including ensuring materials are met as planned, while efficiency aims to reduce time and cost. In this study, material planning will be carried out using the Material Requirement planning (MRP) method, using three different lot measurement techniques, namely Lot for Lot (LFL), Economic Order Quantity (EOQ), and Period Order Quantity (POQ). The MRP method is carried out to accurately calculate the amount of material needed to avoid excessive material inventory levels. After the MRP method, the most optimal number of orders and the total cost required for each lot measurement technique are obtained. The results of this study show that the LFL technique produces the optimum number of orders for gelam wood, plywood, reinforcement, bendrat wire, and ready mix concrete. Meanwhile, for materials such as lubricating oil, meranti wood, randu wood, and nails, it is optimal to order using the POQ technique.
Cost Budget Analysis for Equal Distribution of Labour for Multi-Storey Buildings Construction
Authors: Dewanty Maharani Putri , Putra I Nyoman Dita Pahang 
Published: May 2024

Although all resources on a construction project have their respective roles, the availability of labour significantly impacts how far the project moves forward and is completed. According to Kastor and Sirakoulis (2009), calculating the number of workers according to the construction schedule is crucial because, without this consideration, the resulting schedule may not be effective and efficient. process used for construction project resources to reduce fluctuations (Waluyo & Aditama, 2017). This research compares labour allocation, duration, and labour wage cost budgets under several conditions. These conditions include actual project conditions, planning, and results after levelling using an auto schedule. In project planning, the fluctuations obtained are pretty sharp. After the auto schedule levelling, the manpower no longer experienced overallocation, but fluctuations between weeks were still relatively high. This can happen because the quantity of work and labour in the construction projects under review is not comparable to the effects of project delays. The results obtained from the comparisons analyzed on the X-storey building construction project are that the auto schedule does not change the initial planning duration, which remains at 133 days. There was a disparity of 0.02% in auto schedule planning costs from 1,098,345,000.00. Meanwhile, in actual conditions, the labour cost budget increased by 0.12% from IDR 967,880,000.00 after the auto-schedule levelling process. It can be concluded that before resource levelling is carried out, it is necessary to review project scheduling and accelerate the duration of implementation, specifically if construction projects experience delays and other factors, so as not to cause fluctuations caused by the uneven quantity of work over some time.
PROFIL KADER PEMUDA MUHAMMADIYAH SEBAGAI INTELEKTUAL INFLUENCER
Authors: Nuri R Nurhayati , Ismail Ismail , Nur Makmur Jaya , Kusnadi Kusnadi , Muyassarah  , Haerati Afnan 
Published: May 2024

Abstrak
Jurnal ini mengulas tentang bagaimana profil kader pemuda Muhammadiyah sebagai intelektual influencer. Penelitian ini bertujuan untuk mengetahui bagaimana profil kader Muhammadiyah dalam menjalankan tugasnya atau fungsinya sebagai pemuda intelektual influencer mengingat bahwa militansi kader Muhammadiyah di dunia digital juga harus mengimbangi bahkan bisa lebih dari jumlah kader yang dimiliki dalam struktural. Metode yang digunakan dalam penelitian ini adalah metode pendekatan deskriptif kualitatif dan menggunakan metode studi pustaka (studi pustaka adalah metode yang menggunakan bahan kepustakaan sebagai sumber data). Adapun instrument penelitiannya menggunakan latar alamiah, dengan tujuan untuk mengembangkan pengetahuan karena peneliti di hadapkan langsung dengan data atau teks yang disajikan, bukan melalui data lapangan atau saksi mata melainkan peneliti hanya berhadapan langsung dengan sumber yang ada di perpustakaan atau bersifat siap pakai. Hasil penelitian berupa data analisis tentang beberapa indikator menjadi seorang intelektual influencer seperti seorang kader terlebih dahulu harus mengenali bakat dan minat mereka, kemudian menguasai berbagai platform media sosial, memperluas pergaulan, dan indikator-indikator lain yang harus dipenuhi agar kader pemuda Muhammadiyah tersebut mampu menjadi seorang intelektual influencer.
USO DE OCITOCINA E VIOLÊNCIA OBSTÉTRICA: UMA REVISÃO INTEGRATIVA
Authors: De Souza Karolayne Pereira , de Sousa Passarini Sabrinne , Barbosa da Silva Vitória Marcele , Silva Lima da Costa Ruth 
Published: May 2024

A violência obstétrica, uma preocupação global que afeta uma em cada três mulheres, destaca-se pela falta de conscientização e subnotificação. Objetivo: evidenciar a relação entre o uso de ocitocina e a violência obstétrica. Método: Trata-se de uma revisão integrativa da literatura, conduzida nas bases de dados National Library of Medicine (MEDLINE/PUBMED e Scientific Electronic Library Online (SciELO) com foco em estudos publicados entre 2018 e 2024. Resultados: Os resultados revelaram uma lacuna no conhecimento das mulheres sobre a violência obstétrica, com destaque para experiências ligadas ao uso inadequado de ocitocina. A falta de consentimento para a administração deste medicamento, associada a práticas invasivas como a manobra de kristeller e episiotomia, ressaltam a urgência de intervenções para promover uma assistência ao parto mais respeitosa, ética e alinhada aos direitos das mulheres. Conclusão: Os achados demostram a importância de enfrentar a violência obstétrica, especialmente relacionada ao uso de ocitocina, e enfatizam a necessidade de práticas mais humanizadas na assistência ao parto.
FATORES ASSOCIADOS À INCIDÊNCIA DO CÂNCER DO COLO DO ÚTERO
Authors: Ferreira Lopes Thaynara , Dara Barbosa Verçosa Antônia , Santos Sobrinho Irla , Silva Lima da Costa Ruth 
Published: May 2024

O câncer do colo do útero, também conhecido como câncer cervical, representa uma das preocupações mais significativas em saúde pública, afetando mulheres em todo o mundo. Embora seja uma doença em grande parte previnível e tratável. A incidência desigual do câncer do colo do útero entre diferentes grupos populacionais e regiões geográficas é motivo de preocupação. Objetivo: analisar a relação entre os fatores de risco e os determinantes sociais na incidência do câncer do colo do útero. Métodos: Trata-se de um estudo de revisão integrativa da literatura, com coleta de informações, nas bases de dados na National Library of Medicine (MEDLINE/PUBMED e Scientific Electronic Library Online (SciELO). Resultados: Foi evidenciada a relação entre as disparidades socioeconômicas e demográficas na incidência do câncer de colo do útero. Fatores como idade avançada, raça não branca, baixa escolaridade, baixa renda, falta de parceiro conjugal e dificuldades de acesso aos serviços de saúde foram relacionados ao aumento do risco da doença. Conclusão: políticas de saúde pública devem ser direcionadas para mitigar as disparidades identificadas e promover um acesso equitativo aos serviços de prevenção e tratamento do câncer do colo do útero, independentemente da condição socioeconômica ou demográfica das mulheres.
Rancang Bangun Sistem Pengelolaan Pupuk Bersubsidi pada Subak Desa Bongan Berbasis Web
Authors: Pratama Gusti Made Ngurah Eko Wira , Gunawan Putu Wida , Rahayu Prastyadi Wibawa , Feoh Gerson 
Published: May 2024

Sistem pengelolaan pupuk yang berjalan masih menggunakan buku besar sebagai media pencatatan dan kalkulator sebagai media untuk menghitung pupuk yang masuk maupun yang keluar, sistem yang masih manual menyebabkan beberapa kendala antara lain rekapan data kelompok petani dan pupuk tidak terorganisir dengan baik, pembuatan laporan harian, mingguan, dan bulanan membutuhkan waktu yang lama karena harus merekap data dari buku besar, tujuan dari penelitian ini adalah merancang dan membangun sistem pengelolaan pupuk berbasis web. Metode yang digunakan adalah waterfall. User Questionnaire digunakan untuk menguji tingkat pemahaman dan kepuasan, bahasa pemrograman dgunakan PHP dan HTML, MySQL sebagai database pada web yang penulis buat untuk rancang bangun sistem pengelolaan pupuk bersubsidi.
Penerapan Metode SAW dalam Sistem Pendukung Keputusan Seleksi Siswa Baru pada SMKS Bakti Luhur Tambolaka
Authors: Nuna Adriana Jama , Jangga Adelbertus Umbu , Setiawi Agustina Purnami 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui bagaimana penerapan metode SAW dalam sistem keputusan seleksi siswa baru. Melalui sistem pendukung keputusan dengan menggunakan metode Simple Additive Weighting (SAW) maka diperlukan kriteria-kriteria yang akan dipertimbangkan dalam seleksi penerimaan siswa baru pada SMKS Bakti Luhur Tambolaka. Kriteria-kriteria yang telah ditentukan oleh sekolah adalah nilai tes tertulis, nilai hasil wawancara, nilai rapor SMP, dan penilaian penampilan. Penerapan sistem pendukung keputusan dengan menggunakan metode Simple Additive Weighting (SAW) dalam seleksi penerimaan siswa baru pada SMKS Bakti Luhur Tambolaka dilakukan dengan adanya alternatif yaitu calon siswa, kemudian penentuan bobot pada setiap kriteria. Selanjutnya perhitungan akan dilakukan dengan menggunakan metode Simple Additive Weighting (SAW). Calon siswa yang dinyatakan lolos dalam seleksi penerimaan siswa baru pada SMKS Bakti Luhur Tambolakamelalui sistem pendukung keputusan dengan metode Simple Additive Weighting (SAW) adalah sebanyak 40 siswa dan yang dinyatakan tidak lolos adalah sebanyak 10 siswa.
Comparison of Adaptive Functioning Between Survivors of Childhood Acute Lymphoblastic Leukemia and Their Healthy Peers; An Experience from a Low- and Middle-Income Country
Authors: Meher Afroze  , Saba Mumtaz  , Neelum Abdul Quddoos  , Muhammad Shamvil Ahsraf  , Sarah Bano  
Published: May 2024

Introduction: Acute Lymphoblastic Leukemia (ALL) is the most common cancer diagnosed in children. Advances in treatment increased the survival rates of these children. One important long term aspect of survivorship is adaptive functioning, which plays a pivotal role in a child’s quality of life. This study compares the adaptive functions of childhood leukemia survivors with their healthy peers.
Methods: This descriptive case control study was conducted at the Pediatrics Hematology/ Oncology Department of Indus Hospital and Health Network (IHHN), from November 2022 to April 2023. Survivor children and adolescents aged 12 to 18 years old treated for ALL were included. Cases were divided in two groups: Group A, ALL survivors, and Group B, healthy adolescents matched in age to the ALL survivors. VABS assessment was conducted by a qualified psychologist, to evaluate the adaptive functioning. All the information was entered and analyzed by SPSS version 20.
Results: A total of 50 adolescent children were examined along with 50 healthy controls. 72% of the survivors had B-cell ALL (B-ALL), followed by 22% had T-cell ALL (T-ALL) and 6%, had Mixed Phenotype ALL. Mean of adaptive behavior composite score, communication skills, daily living skills and the socialization skills standard score were significantly lower among patients compared to controls (p=0.0001).
Conclusion: Overall adaptive skills were significantly affected among the survivors. These findings underscore the importance of tailored interventions and support services to enhance the adaptive functioning and overall well-being of these resilient survivors.
Electrochemical Evaluation of Mg and a Mg-Al 5%Zn Metal-Rich Primers for Protection of Al-Zn-Mg-Cu Alloy in NaCl
Authors: Korjenic A. , Blohm L. , Scully J.R. 
Published: May 2024

High-purity magnesium and an Mg-Al 5 wt% Zn metal-rich primer (MRP) were compared for their ability to suppress intergranular corrosion (IGC) and intergranular stress corrosion cracking (IGSCC) in peak aged AA7075-T651 by sacrificial anode-based cathodic prevention. Tests were conducted in 0.6 M NaCl solution under full immersion. These evaluations considered the ability of the primer to attain an intermediate negative open-circuit potential (OCP) such that the galvanic couple potential with bare aluminum alloy (AA) 7075-T651 resided below a range of potentials where IGC is prevalent. The ability of the primer to achieve an OCP negative enough that the AA7075-T651 could be protected by sacrificial anode-based cathodic prevention and the ability to sustain this function over time were evaluated as a first step by utilizing a NaCl solution. The primers consisted of epoxy resins embedded with either (1) Mg flake pigments (MgRP) or (2) Mg flake pigments and spherical Al-5 wt% Zn together as a composite (MgAlRP). A variety of electrochemical techniques were used to evaluate the performance including OCP monitoring, electrochemical impedance spectroscopy, diagnostic DC/AC/OCP cycle testing, and zero resistance ammeter tests with simultaneous pH measurements. Electrochemical DC/AC/OCP cycle testing in 0.6 M NaCl demonstrated that MgRP reached a suitable OCP for the cathodic protection of AA7075-T651. MgRP was an effective coating for cathodic protection but dispensed less anodic charge than the composite MgAlRP. Cross-sectional analysis demonstrated that some Mg flakes dissolved while uniform surface oxidation occurred on the remaining Mg flakes which led to impaired activation. The composite MgAlRP maintained a suitably negative OCP over time, remained activated, dispensed high anodic charge, and remained an anode in zero resistance ammeter testing. Chemical stability modeling and zero resistance ammeter testing suggest that Mg corrosion elevates the pH which dissolved aluminum oxides and hydroxide thereby activating the Al-5 wt% Zn pigments, providing a primary (i.e., Mg corrosion) and secondary process to enable superior (activation of Al-5 wt% Zn) sacrificial anode-based cathodic protection.
Aproximación conceptual a la contratación estatal en Colombia
Authors: Cardona-Londoño Juan Carlos , Lopera-Graciano Karina Inés , Ochoa-Duarte Carlos Mario 
Published: May 2024

Uno de los conceptos de mayor complejidad en el ámbito normativo colombiano es el contrato administrativo estatal, en ocasiones distorsionado en su interpretación. El presente ensayo tiene como objetivo analizar la concepción teórica de la contratación administrativa estatal en Colombia. En su cumplimiento se desarrolló un estudio de revisión bibliográfica, sustentado en los métodos de investigación: exegético, histórico-lógico y hermenéutico, así como la técnica de análisis de contenido. Entre los principales resultados se significan: 1) recuento normativo de la contratación estatal mediante la sistematización de los cuatro principales estatutos de contratación pública de finales del siglo XX, edificados, la gran mayoría de ellos, por potestades extraordinarias que tanto la Constitución Política de 1886 como la de 1991 le confirió al presidente de la República, siendo la única excepción el actual Estatuto General de la Contratación de la Administración Pública; 2) análisis de las etapas de formación de contrato estatal; 3) descripción de la tipología de contrato estatal expuesta en la Ley 80 de 1993 y 5) explicación de la liquidación del contrato estatal.