bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periodontal disease progression and glycaemic control among Gullah African Americans with type‐2 diabetes
Authors: Bandyopadhyay Dipankar , Marlow Nicole M. , Fernandes Jyotika K. , Leite Renata S. 
Published: May 2010

Bandyopadhyay D, Marlow NM, Fernandes JK, Leite RS: Periodontal disease progression and glycaemic control among Gullah African Americans with type‐2 diabetes. J Clin Periodontol 2010; 37: 501–509. doi: 10.1111/j.1600‐051X.2010.01564.x.AbstractAim: To evaluate associations between glycaemic control and periodontitis progression among Gullah African Americans with type‐2 diabetes mellitus (T2DM).Materials and Methods: From an ongoing clinical trial among T2DM Gullah, we extracted a cohort previously in a cross‐sectional study (N=88). Time from baseline (previous study) to follow‐up (trial enrollment, before treatment interventions) ranged 1.93–4.08 years [mean=2.99, standard deviation (SD)=0.36]. We evaluated tooth site‐level periodontitis progression [clinical attachment loss (CAL) worsening of 2 mm, periodontal probing depth (PPD) increases of 2 mm and bleeding on probing (BOP) from none to present] by glycaemic control status (well‐controlled=HbA1c<7%, poorly‐controlled=HbA1c7%) using multivariable generalized estimating equations logistic regression, nesting tooth sites/person.Results: Poorly‐controlled T2DM (68.18%) was more prevalent than well‐controlled T2DM (31.82%). Proportions of tooth sites/person with CAL progression between baseline and follow‐up ranged 0.00–0.59 (mean=0.12, SD=0.12), while PPD and BOP progression ranged 0.00–0.44 (mean=0.09, SD=0.11) and 0.00–0.96 (mean=0.24, SD=0.18), respectively. Site‐level PPD at baseline was a significant effect modifier of associations between poorly‐controlled T2DM and site‐level CAL and PPD progression [adjusted odds ratios (OR) according to poorly‐controlled T2DM among PPD at baseline=3, 5 and 7 mm, respectively: CAL progression=1.93, 2.64, and 3.62, PPD progression=1.98, 2.76, and 3.84; p<0.05 for all]. Odds of site‐level BOP progression were increased (OR=1.24) for poorly‐controlled T2DM, yet the results were not significant (p=0.32).Conclusions: These findings from a distinct, homogenous population further support the clinical relevance of identifying patients with poor glycaemic control and periodontitis, particularly among those with disparities for both diseases.
Tooth‐related risk factors for periodontal disease in community‐dwelling elderly people
Authors: Hirotomi Toshinobu , Yoshihara Akihiro , Ogawa Hiroshi , Miyazaki Hideo 
Published: May 2010

Hirotomi T, Yoshihara A, Ogawa H, Miyazaki H. Tooth‐related risk factors for periodontal disease in community‐dwelling elderly people. J Clin Periodontol 2010; 37: 494–500. doi: 10.1111/j.1600‐051X.2010.01565.x.AbstractObjective: While most previous epidemiological studies have focused on subject‐level risk factors for periodontal destruction, tooth‐related factors have not been fully explored. The purpose of this study was to evaluate both tooth‐related and subject‐related factors affecting periodontal disease progression using a two‐level multilevel model.Material and Methods: A longitudinal survey over a period of 10 years was carried out on 286 community‐dwelling elderly subjects aged 70 years at baseline. Clinical attachment level (CAL) was measured at six sites per tooth on all teeth present and periodontal disease progression was defined as CAL3 mm.Results: Periodontal disease progression was found in 79% of the subjects and most frequently in maxillary molars. Multilevel logistic regressions revealed that subjects wearing removable dentures were significantly at risk for periodontal disease progression. Abutment teeth for removable/fixed dentures were also significantly more likely to suffer periodontal breakdown. Furthermore, the following tooth‐related variables were found to be possible risk factors for periodontal disease progression: maxillary and multirooted teeth.Conclusion: Multirooted teeth and abutments for a fixed denture were possible risk factors for periodontal disease progression.
Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration: an experimental study in the dog
Authors: Stavropoulos Andreas , Wikesjö Ulf M. E. 
Published: May 2010

Stavropoulos A, Wikesjö UME. Influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a bovine bone biomaterial and provisions for guided tissue regeneration: an experimental study in the dog. J Clin Periodontol 2010; 37: 534–543. doi: 10.1111/j.1600‐051X.2010.01566.x.AbstractObjective: To evaluate the influence of defect dimensions on periodontal wound healing/regeneration in intrabony defects following implantation of a deproteinized bovine bone/collagen matrix under provisions for guided tissue regeneration.Material and Methods: Contra‐lateral one‐wall intrabony [6 × 6 mm (wide/deep) versus 4 × 4 mm (narrow/shallow)] periodontal defects were surgically created at the edentulated mesial aspect of the mandibular first molars in three Labradors, i.e., three defects in each category. The defects were implanted with the bovine bone/collagen matrix and covered with a collagen membrane. Histologic/histometric analysis followed an 18‐month healing interval.Results: New cementum encompassed the entire intrabony component in both wide/deep (5.6 ± 0.5 mm) and narrow/shallow (4.2 ± 0.1 mm) defects; bone formation amounted to 5.6 ± 0.6 and 4.0 ± 0.8 mm, respectively. Mineralized bone encompassed 57.5%versus 65% and the bone biomaterial 11.6%versus 13.1% of the defect space. A periodontal ligament with a width and composition similar to that of the resident periodontal ligament encompassing the entire aspect of the defects was observed. Root resorption/ankylosis was rare.Conclusions: Both wide/deep and narrow/shallow intrabony defects showed a substantial potential for periodontal regeneration in this pre‐clinical model. The contribution of the bovine bone/collagen matrix and guided tissue regeneration to this regenerative potential is not clear.
Healing of two and three wall intrabony periodontal defects following treatment with an enamel matrix derivative combined with autogenous bone
Authors: Yilmaz Selcuc , Cakar Gokser , Yildirim Burak , Sculean Anton 
Published: May 2010

Yilmaz S, Cakar G, Yildirim B, Sculean A. Healing of two and three wall intrabony periodontal defects following treatment with an enamel matrix derivative combined with autogenous bone. J Clin Periodontol 2010; 37: 544–550. doi: 10.1111/j.1600‐051X.2010.01567.x.AbstractBackground: There are still limited data on the outcomes of regenerative periodontal surgery using a combination of an enamel matrix protein derivative (EMD) and autogenous bone (AB).Aim: To evaluate the healing of deep intrabony defects treated with either a combination EMD+AB or EMD alone.Materials and Methods: Forty patients with advanced chronic periodontitis, with one deep intrabony defect, were randomly treated with either EMD+AB (test) or EMD (control). Clinical assessments were performed at baseline and at 1 year after treatment. The primary outcome variable was relative attachment level (RAL).Results: Healing was uneventful in all patients. The test sites showed a reduction in the mean probing pocket depth (PPD) of 5.6 ± 0.9 mm (p<0.001), a gain in the mean RAL of 4.2 ± 1.1 mm (p<0.001) and a gain in the mean probing bone level (PBL) of 3.9 ± 1.0 mm (p<0.001). The control group displayed a mean PPD reduction of 4.6 ± 0.4 mm (p<0.001), a mean RAL gain of 3.4 ± 0.8 mm (p<0.001) and a mean PBL gain of 2.8 ± 0.8 mm (p<0.001). RAL gains of 4 mm were measured in 90% of the test defects and in 55% of the controls. PBL gains of 4 mm were obtained in 85% of the test defects and in 25% of the control ones. The test treatment resulted in statistically higher PPD reductions, RAL gains and PBL gains compared with the control (p<0.01).Conclusions: Within their limits, the present results indicate that: (i) at 1 year after surgery, both therapies resulted in statistically significant clinical improvements compared with baseline and (ii) although the combination of EMD+AB resulted in statistically significant higher soft and hard tissue improvements compared with treatment with EMD, the clinical relevance of this finding is unclear.
MDM2 SNP309 promoter polymorphism, an independent prognostic factor in chronic lymphocytic leukemia
Authors: Willander Kerstin , Ungerbäck Jonas , Karlsson Karin , Fredrikson Mats , Söderkvist Peter , Linderholm Mats 
Published: May 2010

AbstractBackground:  The single nucleotide polymorphism SNP309 with a change from T to G in the promoter region of the MDM2 gene is shown to increase the MDM2 protein levels and attenuate the p53 levels and associates with disease progression in several tumors.Objective:  In this study, the role of the polymorphism was investigated with regard to the clinical outcome in B‐cell chronic lymphocytic leukemia (B‐CLL).Patients:  A total of 210 patients with B‐CLL were followed for up to 19 yr.Results:  The overall survival (OS) of patients with at least one G‐allele was significantly shorter when compared with those with two T‐alleles (P = 0.024) with a more pronounced difference in patients below the median age. Age at onset of B‐CLL was similar irrespective of MDM2 status. The presence of a G‐allele in combination with TP53 mutations or unmutated IgVH gene status resulted in an additive risk of death.Conclusion:  In this report, with a high proportion of B‐CLL patients with an advanced Binet stage and with an unmutated IgVH gene, MDM2 SNP309 was found to be independently associated with OS. The survival difference was more pronounced in younger patients.
Prostaglandin D2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin production
Authors: Masoodi Mojgan , Nicolaou Anna , Gledhill Karl , Rhodes Lesley E. , Tobin Desmond J. , Thody Anthony J. 
Published: May 2010

Please cite this paper as: Prostaglandin D2 production in FM55 melanoma cells is regulated by α‐melanocyte‐stimulating hormone and is not related to melanin production. Experimental Dermatology 2010; 19: 751–753.Abstract:  This study shows that prostaglandins in human FM55 melanoma cells and epidermal melanocytes are produced by COX‐1. Prostaglandin production in FM55 melanoma cells was unrelated to that of melanin suggesting that the two processes can occur independently. α‐Melanocyte‐stimulating hormone, which had no effect on melanin production in FM55 cells, stimulated PGD2 production in these cells without affecting PGE2. While cAMP pathways may be involved in regulating PGD2 production, our results suggest that α‐MSH acts independently of cAMP, possibly by regulating the activity of lipocalin‐type PGD synthase. This α‐MSH‐mediated effect may be associated with its role as an immune modulator.
Dental hygienists’ views on communicative factors and interpersonal processes in prevention and treatment of periodontal disease
Authors: Stenman J , Wennström JL , Abrahamsson KH 
Published: May 2010

To cite this article:

Int J Dent Hygiene 8, 2010; 213–218 DOI: 10.1111/j.1601‐5037.2010.00459.x Stenman J, Wennström JL, Abrahamsson KH. Dental hygienists’ views on communicative factors and interpersonal processes in prevention and treatment of periodontal disease.Abstract:  Objective:  The aim of this study was to explore views of DHs on communicative issues and interpersonal processes of importance in the prevention and treatment of periodontal disease.Method:  The qualitative method of Grounded Theory (GT) was chosen for data sampling and analysis. Audio‐taped and open‐ended interviews were conducted with 17 dental hygienists. The interviews were transcribed verbatim and analysed in a hierarchical coding process, according to the principles of GT.Result:  In the analysis a core category was identified as ‘to be successful in information and oral health education and managing desirable behavioural changes’. The core concept was related to four additional categories and dimensions; (i) ‘to establish a trustful relationship with the patient’, (ii) ‘to present information about the oral health status and to give oral hygiene instructions’, (iii) ‘to be professional in the role as a dental hygienist’ and (iv) ‘to have a supportive working environment in order to feel satisfaction with the work and to reach desirable treatment results’.Conclusion:  The results describe a psychosocial process that elucidates the importance of building a trustful relationship with the patient, feeling secure in one’s professional role as a DH and last but not least, the importance of having support from colleagues and the clinical manager to be successful in the prevention and treatment of periodontal diseases.
Bacteraemia in children in Iceland 1994–2005
Authors: Árnason Sigurður , Thors Valtýr Stefánsson , Guðnason Thórólfur , Kristinsson Karl G. , Haraldsson Ásgeir 
Published: May 2010

AbstractAim:  To investigate the aetiology of bacteraemia in children in Iceland, the antibiotic resistance and possible preventive measures.Methods:  All positive bacterial blood cultures from children 0–18 years old isolated at Landspítali University Hospital Iceland from 1994 to 2005 were included in the study. Epidemiological and microbiological data were registered. The blood cultures were categorized according to likelihood of infection or contamination.Results:  During the study period 1253 positive blood cultures were obtained from 974 children; 647 from boys and 606 from girls. Positive blood cultures were most common during the first year of life (594; 47.4%) with 252 of them from neonates. Coagulase negative staphylococci were most common (37%). Of probable or definite infections Streptococcus pneumoniae was the most common (19.3%) followed by Staphylococcus aureus (17.6%) and Neisseria meningitidis (13.5%). The most common pneumococcal serogroups were 23, 6, 7, 19 and 14. Commercially available vaccines contain up to 88% of all pneumococcal strains and 67% of all multi‐resistant strains. N. meningitidis group C was not isolated after vaccinations were started in 2002.Conclusion:  Our study provides important epidemiological data on bacterial bloodstream infections in children in Iceland. The results demonstrate the excellent efficacy of meningococcal group C vaccination.
A 4‐ to 5‐Year Retrospective Clinical and Radiographic Study of Neoss Implants Placed with or without GBR Procedures
Authors: Zumstein Thomas , Billström Camilla , Sennerby Lars 
Published: May 2010

ABSTRACTBackground: New dental implant systems are continuously introduced to the market. It is important that clinicians report their experiences with these implants when used in different situations.Aim: The study aims to report the outcomes from a retrospective study on Neoss implants when used with or without guided bone regeneration (GBR) procedures.Materials and Methods: The study group comprised of 50 consecutive patients previously treated with 183 Neoss implants (Neoss Ltd., Harrogate, UK) in 53 sites because of single, partial, or total tooth loss. Implants were placed in healed bone in 23 sites, while a GBR procedure was used in 30 sites in conjunction with implant placement. A healing period of 3 to 6 months was utilized in 45 sites and in 8 sites a crown/bridge was fitted within a few days for immediate/early function. The number of failures, withdrawn and dropout implants was analyzed in a life‐table. All available intraoral radiographs from baseline and annual check‐ups were analyzed with regard to marginal bone level and bone loss.Results: A cumulative survival rate (CSR) of 98.2% was found for the non‐GBR group and 93.5% for the GBR group with an overall CSR of 95.0% after up to 5 years of loading. In spite of the failures, all patients received and maintained their prostheses. Based on all available radiographs, the bone level was situated 1.3 ± 0.8 mm (n = 159) below the top of the collar at baseline and 1.7 ± 0.8 mm (n = 60) after 5 years of follow‐up. Based on paired baseline and 1‐year (n = 70) and 5‐year radiographs (n = 59), the bone loss was found to be 0.4 ± 0.9 and 0.4 ± 0.9 mm, respectively. There were no statistically significant differences between GBR and non‐GBR sites with regard to implant survival or bone loss.Conclusions: The Neoss implant system showed good clinical and radiographic results after up to 5 years in function.
A study of the efficacy of ultrasonic waves in removing biofilms
Authors: Nishikawa Takeshi , Yoshida Akihiro , Khanal Amit , Habu Manabu , Yoshioka Izumi , Toyoshima Kuniaki , Takehara Tadamichi , Nishihara Tatsuji , Tachibana Katsuro , Tominaga Kazuhiro 
Published: May 2010

doi:10.1111/j.1741‐2358.2009.00325.x

A study of the efficacy of ultrasonic waves in removing biofilms Objective:  The removal of adherent biofilms was assessed using ultrasonic waves in a non‐contact mode.Materials and Methods:  In in vitro experiments, Streptococcus mutans (S. mutans) biofilms were exposed to ultrasonic waves at various frequencies (280 kHz, 1 MHz, or 2 MHz), duty ratios (0–90%), and exposure times (1–3 minutes), and the optimal conditions for biofilm removal were identified. Furthermore, the effect of adding a contrast medium, such as micro bubbles (Sonazoid®), was examined. The spatial distribution and architecture of S. mutans biofilms before and after ultrasonic wave exposure were examined via scanning electron microscopy. The biofilm removal effect was also examined in in vivo experiments, using a custom‐made oral cleaning device.Results:  When a 280 kHz probe was used, the biofilm‐removing effect increased significantly compared to 1 and 2 MHz probes; more than 80% of the adherent biofilm was removed with a duty cycle of 50–90% and a 3 minutes exposure time. The maximum biofilm‐removing effect was observed with a duty cycle of 80%. Furthermore, the addition of micro bubbles enhanced this biofilm‐removing effect. In in vivo experiments, moderate biofilm removal was observed when a 280 kHz probe was used for 5 minutes.Conclusions:  This study demonstrated that ultrasonic wave exposure in a non‐contact mode effectively removed adherent biofilms composed of S. mutans in vitro.
On the anomalous silicate absorption feature of the prototypical Seyfert 2 galaxy NGC1068
Authors: Köhler M. , Li Aigen 
Published: May 2010

Abstract
The first detection of the silicate absorption feature in Active Galactic Nuclei (AGNs) was made at 9.7μm for the prototypical Seyfert 2 galaxy NGC1068 35 yr ago, indicating the presence of a large column of silicate dust in the line of sight to the nucleus. It is now well recognized that type 2 AGNs exhibit prominent silicate absorption bands, while the silicate bands of type 1 AGNs appear in emission. More recently, using the Mid-Infrared Interferometric Instrument on the Very Large Telescope Interferometer, Jaffe et al. for the first time spatially resolved the parsec-sized dust torus around NGC1068 and found that the 10μm silicate absorption feature of the innermost hot component exhibits an anomalous profile differing from that of the interstellar medium and that of common olivine-type silicate dust. While they ascribed the anomalous absorption profile to gehlenite (Ca2Al2SiO7, a calcium aluminium silicate species), we propose a physical dust model and argue that, although the presence of gehlenite is not ruled out, the anomalous absorption feature mainly arises from silicon carbide.
Real‐time Visualization of Photochemically Induced Fluorescence of 8‐Halogenated Quinolones: Lomefloxacin, Clinafloxacin and Bay3118 in Live Human HaCaT Keratinocytes†
Authors: Koker Edmond B. , Bilski Piotr J. , Motten Ann G. , Zhao Baozhong , Chignell Colin F. , He Yu‐Ying 
Published: May 2010

AbstractHalogenoquinolones are potent and widely used antimicrobials blocking microbial DNA synthesis. However, they induce adverse photoresponses through the absorption of UV light, including phototoxicity and photocarcinogenicity. The phototoxic responses may be the result of photosensitization of singlet oxygen, production of free radicals and/or other reactive species resulting from photodehalogenation. Here, we report the use of laser scanning confocal microscopy to detect and to follow the fluorescence changes of one monohalogenated and three di‐halogenated quinolones in live human epidermal keratinocyte cells during in situ irradiation by confocal laser in real time. Fluorescence image analysis and co‐staining with the LysoTracker probe showed that lysosomes are a preferential site of drug localization and phototransformations. As the lysosomal environment is relatively acidic, we also determined how low pH may affect the dehalogenation and concomitant fluorescence. With continued UV irradiation, fluorescence increased in the photoproducts from BAY y3118 and clinafloxacin, whereas it decreased for lomefloxacin and moxifloxacin. Our images not only help to localize these phototoxic agents in the cell, but also provide means for dynamic monitoring of their phototransformations in the cellular environment.
Novel Photodynamic Therapy Using Water‐dispersed TiO2–Polyethylene Glycol Compound: Evaluation of Antitumor Effect on Glioma Cells and Spheroids In Vitro
Authors: Yamaguchi Shigeru , Kobayashi Hiroyuki , Narita Takuhito , Kanehira Koki , Sonezaki Shuji , Kubota Yoshinobu , Terasaka Shunsuke , Iwasaki Yoshinobu 
Published: May 2010

AbstractTitanium dioxide (TiO2) is thought to be a photocatalytic agent excited by UV light. Our aim was to investigate the photocatalytic antitumor effect of water‐dispersed TiO2 nanoparticles on C6 rat glioma cells and to evaluate the treatment responses by the spheroid models. Water‐dispersed TiO2 nanoparticles were constructed by the adsorption of chemical modified polyethylene glycol (PEG) on the TiO2 surface (TiO2/PEG). Each monolayer and spheroid of C6 cells was coincubated with various concentrations of TiO2/PEG and subsequently irradiated with UV light. Damage of the cells and spheroids was evaluated sequentially by staining with the fluorescent dyes. The cytotoxic effect was correlated with the concentration of TiO2/PEG and the energy dose of UV irradiation. More than 90% of cells were killed after 13.5 J cm−2 of UV irradiation in the presence of 500 μg mL−1 TiO2/PEG. The irradiated spheroids in the presence of TiO2/PEG showed growth suppression compared with control groups. In TiO2/PEG‐treated spheroids, the number of Annexin V‐FITC‐stained cells gradually increased during the first 6 h, and subsequently propidium iodide‐stained cells appeared. The results of this study suggest that newly developed photoexcited TiO2/PEG have antitumoral activity. Photodynamic therapy utilizing this material can be a clue to a novel therapeutic strategy for glioma.