bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting survival, neurotoxicity and response in B-Cell lymphoma patients treated with CAR-T therapy using an imaging features-based model
Authors: Ferrer-Lores Blanca , Ortiz-Algarra Alfonso , Picó-Peris Alfonso , Estepa-Fernández Alejandra , Bellvís-Bataller Fuensanta , Weiss Glen J. , Fuster-Matanzo Almudena , Fernández Juan Pedro , Jimenez-Pastor Ana , Hernani Rafael , Saus-Carreres Ana , Benzaquen Ana , Ventura Laura , Piñana José Luis , Teruel Ana Belén , Serrano-Alcalá Alicia , Dosdá Rosa , Sopena-Novales Pablo , Balaguer-Rosello Aitana , Guerreiro Manuel , Sanz Jaime , Martí-Bonmatí Luis , Terol María José , Alberich-Bayarri Ángel 
Published: June 2024

Abstract

Background:
This study aims to develop imaging-based prognostic and predictive models for relapsed/refractory (R/R) B-cell lymphoma patients undergoing CAR-T therapy by integrating clinical data and imaging features. Specifically, our aim was to predict 3- and 6-month treatment response, overall survival (OS), progression-free survival (PFS), and the occurrence of the immune effector cell-associated neurotoxicity syndrome (ICANS).
Methods:
This multicentre retrospective observational study includes 65 patients of R/R B-cell lymphoma treated with CAR-T cells in two centres. Pre-infusion 18F-FDG PET/CT scans and clinical data were systematically collected. Imaging features were extracted using the Quibim platform. Logistic regression was employed for predicting ICANS and CAR-T response, while univariate and multivariate analyses Cox proportional-hazards models were performed for survival prediction. Models with best overall fit based on Akaike information criterion and with 10-fold repeated cross-validation were selected.
Results:
Sixty-five patients with a median age of 62 (range 21–76) years were evaluated. The median follow-up for survivors was 10.47 (range 0.20–45.80) months. A logistic regression model accurately predicted neurotoxicity (AUC: 0.830), and models for CAR-T response at 3 and 6 months demonstrated high accuracy (AUC: 0.928 and 0.940, respectively). Median OS after CAR-T therapy was 4.73 months for high total metabolic tumour volume (MTVtotal) and 37.55 months for low MTVtotal. Predicted PFS was 2.73 months for high MTVtotal and 11.83 months for low MTVtotal. For all outcomes, predictive models, combining imaging features and clinical variables, showed improved accuracy compared to models using only clinical variables or imaging features alone.
Conclusion:
This study successfully integrates imaging features and clinical variables to predict outcomes in R/R B-cell lymphoma patients undergoing CAR-T. Notably, the identified MTVtotal cut-off effectively stratifies patients, as evidenced by significant differences in OS and PFS. Additionally, the predictive models for neurotoxicity and CAR-T response show promising accuracy. This comprehensive approach holds promise for risk stratification and personalized treatment strategies which may become a helpful tool for optimizing CAR-T outcomes in R/R lymphoma patients.
Design of Memristor Based Modified Synapse Circuit for Low-Power Neuromorphic Computing
Authors: Hazari Tarif Ahammad Fuad , Bhuiyan A.B.M. Noushad , Hossain Md. Israil 
Published: June 2024

Abstract

It is high time that brain-inspired or neuromorphic computing must have enough concentration to grow and overcome the computational barrier, which will mimic the biological neuron cell, and its computational abilities will be applied from the neuroscience point of view. We have shown some current candidates from the material to device level for neuromorphic computing and how our proposed memristor-based bridge synapse circuit can emulate the spiking properties of neurons in biological brains with plasticity phenomena such as LTP, LTD and STDP or SRDP (spike rate-dependent plasticity), considering that low power consumption is the primary key to this kind of computing.
Transcrustal magmatic system in lamprophyre dyke constructed by multiple magma reservoirs
Authors: Wang Xiangsong , Wang Yannan , Sun Min , Zhao Guochun , Cai Keda , Liu Xijun , Li Zhenglin , Zhang Yunying , Leppard Fenn 
Published: June 2024

Abstract
The mineral assemblages, chemistry and textures of igneous rocks can record crucial information on magmatic processes in transcrustal magmatic systems. To effectively identify such processes, we present systematic petrological, mineralogical, and geochronological data for a suite of lamprophyre dykes that intruded early flood basalts in the Tuoyun basin of Western Tianshan. The lamprophyre dykes show ocean island basalt-like trace element patterns and depleted Sr–Nd isotope compositions, suggesting that they were derived from a depleted mantle source. Apatite U-Pb dating reveals that the lamprophyre dykes were emplaced at 66 Ma. These lamprophyre dykes consist of three groups of mineral assemblages: (I) Type-I Clinopyroxene (Cpx); (II) Amphibole (Amp) core and Apatite (Ap); and (III) Amp rim, Type-II Cpx, K-feldspar (Kfs) and Plagioclase (Pl). These mineral assemblages are in chemical disequilibrium and correspond to three magma reservoirs within the transcrustal magmatic system. Textural and geochemical features demonstrate that Type-I Cpx represents antecrysts captured from lower crustal crystal mushes. The Amp cores have the same rare earth element patterns as their enclosed Type-I Cpx inclusions, demonstrating that the Amp cores were produced through peritectic reactions consuming Cpx. The third assemblages occur as microlites that formed by the shallow crystallization of evolved melts. Thermobarometric calculations suggest a lower crust magma reservoir at 20–30 km depth, a middle crust magma reservoir at ~15 km depth, and a shallow upper crust magma reservoir at &lt;5 km depth, making up a magma plumbing system of the lamprophyre dykes. The transcrustal magmatic system involves multiple stages of open-system processes, including the recycling of early-formed crystals, multiple magma replenishment, peritectic reactions, and crystal fractionation, resulting in the formation of lamprophyre dykes.
Investigating the Impact of COVID-19 on the Incidence of Cardiovascular Diseases: A Cross-sectional Study
Authors: Sardu Ehsan Goroei , Raesi Rasoul , Pooladvand Vahid , Ardaneh Mahdieh , Daneshi Salman , Mosavi Seyed Abolfazl , Tabatabaee Seyed Saeed 
Published: June 2024

Background
The inflammation caused by COVID-19 can cause blood clots, block the heart vessels and lead to heart attack.

Aim
This study aims toinvestigate the impact of COVID-19 on heart diseases in patients referred to Imam Khomeini Hospital in Jiroft City.

Methods
This is a cross-sectional (descriptive-analytical) study. The statistical population includes all cardiovascular patients who visited Imam Khomeini Hospital two years before Corona (March 2017 to March 2019) and two years after Corona (March 2019 to March 2021). Data were analyzed using SPSS software version 20. The chi-square test was used to investigate the relationship between qualitative variables in two groups. The level of significance in this study was considered less than 0.05.

Results
The average age of patients before COVID-19 was 60.02 ± 16.7 years, and during COVID-19 was 63.9 ± 16.8 years, and in group 1, 50.5% were men, and in group 2, 51% were women. COVID-19 has caused a 14.2% increase in cardiovascular diseases. Acute coronary syndrome, heart attacks, and heart failure increased by 11.3%, 32.2%, and 9.5%, respectively, during the COVID-19pandemic compared to before the COVID-19 pandemic.

Conclusion
Based on the findings of the study, special attention should be paid to the cardiovascular support of these patients and specific diagnostic and treatment protocols should be developed to prevent cardiovascular complications and treat patients with COVID-19.
Nourishing the Infant Gut Microbiome to Support Immune Health: Protocol of SUN (Seeding Through Feeding) Randomized Controlled Trial
Authors: Wall Clare R , Roy Nicole  C , Mullaney Jane A , McNabb Warren Charles , Gasser Olivier , Fraser Karl , Altermann Eric , Young Wayne , Cooney Janine , Lawrence Robyn , Jiang Yannan , Galland Barbara C , Fu Xiaoxi , Tonkie Jacqueline N , Mahawar Nisha , Lovell Amy Luisa 
Published: June 2024

Background
The introduction of complementary foods during the first year of life influences the diversity of the gut microbiome. How this diversity affects immune development and health is unclear.

Objective
This study evaluates the effect of consuming kūmara or kūmara with added banana powder (resistant starch) compared to a reference control at 4 months post randomization on the prevalence of respiratory tract infections and the development of the gut microbiome.

Methods
This study is a double-blind, randomized controlled trial of mothers and their 6-month-old infants (up to n=300) who have not yet started solids. Infants are randomized into one of 3 groups: control arm (C), standard kūmara intervention (K), and a kūmara intervention with added banana powder product (K+) to be consumed daily for 4 months until the infant is approximately 10 months old. Infants are matched for sex using stratified randomization. Data are collected at baseline (prior to commencing solid food) and at 2 and 4 months after commencing solid food (at around 8 and 10 months of age). Data and samples collected at each timepoint include weight and length, intervention adherence (months 2 and 4), illness and medication history, dietary intake (months 2 and 4), sleep (diary and actigraphy), maternal dietary intake, breast milk, feces (baseline and 4 months), and blood samples (baseline and 4 months).

Results
The trial was approved by the Health and Disability Ethics Committee of the Ministry of Health, New Zealand (reference 20/NTA/9). Recruitment and data collection did not commence until January 2022 due to the COVID-19 pandemic. Data collection and analyses are expected to conclude in January 2024 and early 2025, respectively. Results are to be published in 2024 and 2025.

Conclusions
The results of this study will help us understand how the introduction of a specific prebiotic complementary food affects the microbiota and relative abundances of the microbial species, the modulation of immune development, and infant health. It will contribute to the expanding body of research that aims to deepen our understanding of the connections between nutrition, gut microbiota, and early-life postnatal health.

Trial Registration
Australian New Zealand Clinical Trials Registry ACTRN12620000026921; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378654

International Registered Report Identifier (IRRID)
DERR1-10.2196/56772
1438-P: Trends in Obesity and GLP-1RA Use among Youth and Adults with Type 1 Diabetes in U.S. Health System—2008–2022
Authors: XU YUNWEN , FANG MICHAEL , CORESH JOSEF , GRAMS MORGAN , SELVIN ELIZABETH , SHIN JUNG-IM 
Published: June 2024

Introduction & Objective: As data on medication use in type 1 diabetes (T1D) is scarce, we aimed to characterize trends in obesity and glucagon-like peptide-1 receptor agonists (GLP-1RA) use among US youth and adults with T1D from 2008-2022.
Methods: We identified patients with T1D using a validated algorithm using deidentified electronic health record data from the Optum Labs Data Warehouse. Body mass index (BMI) categories were based on age- and sex-specific percentiles for youth (2-19 years) and WHO criteria for adults (≥20 years). We characterized trends in overweight and obesity, and GLP1-RA prescriptions by BMI categories from 2008-2010 to 2020-2022.
Results: We included 159,879 patients with T1D (19% youth, mean age 39 years, 49% female, 77% non-Hispanic White). From 2008-2010 to 2020-2022, obesity in youth increased from 19% to 26% (P&lt;.001), and severe obesity from 4% to 11% (P&lt;.001) (Figure A). In adults, obesity rose from 28% in 2008-2010 to 37% in 2020-2022 (P&lt;.001) (Figure B). There was a rapid uptake of GLP-1RA over the last 15 years, particularly in severe obesity (Figure C-D). In 2020-2022, GLP-1RA was used by 18% of youth and 34% of adults with severe obesity.
Conclusion: Obesity has reached epidemic levels in patients with T1D. The off-label prescription of GLP-1RA significantly increased over time, especially in severe obesity. More data on GLP-1RA's effects in the T1D population is needed.

Disclosure
Y. Xu: None. M. Fang: None. J. Coresh: Consultant; SomaLogic, Healthy.io. M. Grams: None. E. Selvin: None. J. Shin: None.
1660-P: Efficacy and Safety of Tirzepatide for the Treatment of Obesity in Adults with Type 1 Diabetes—The Mayo Clinic Experience
Authors: TAMA ELIF , BECHENATI DIMA , BENNETT PAMELA , MCNALLY ALLYSON , RIVERA RENE , FANSA SIMA , ANAZCO DIEGO , ACOSTA ANDRES , HURTADO MARIA D. 
Published: June 2024

Introduction: The efficacy and safety of tirzepatide for the treatment of overweight/obesity are well established in adults with type 2, but not type 1, diabetes (T1D). We aim to evaluate the efficacy and safety of tirzepatide for the treatment of obesity in adults with T1D.
Methods: This is a retrospective study of adults with T1D treated with tirzepatide for obesity. Exclusion criteria: tirzepatide use for &lt;3 months, use of other antiobesity medications, and active malignancy. Endpoints: total body weight loss (TBWL) percentage at 3, 6, and 12 months of treatment; TBWL%, change in HbA1c, total daily insulin dose [TDD], and continuous glucose monitor parameters (time in-, above-, and below range [TIR, TAR, and TBR, respectively]) from baseline to last-follow-up; and incidence of side effects, severe hypoglycemia, and diabetes ketoacidosis (DKA). We used matched pair t-test to analyze data. Data are presented as median [IQR].
Results: We included 52 patients: 58% female, 98% White, age 50 years [39-58], BMI 36 kg/m2 [32-42]. TBWL at 3, 6, and 12 months was 6% [3-9] (n=44), 8% [5-15] (n=29), and 14% [7-22] (n=13), respectively (p&lt;0.001 for all). From baseline to the last follow up, median time of 6 months [4-11], TBWL% decreased by 8% [5-14], Hba1c by 1% [0.2-1.8], TDD by 32% [6-45], and TAR by 28% [8-48], p&lt;0.001 for all. TIR increased by 29% [3-55], p&lt;0.001. There was a trend for a decrease in TBR of 32% [0-78], p=0.08. No episodes of severe hypoglycemia or DKA were recorded. The incidence of side effects was 26%, the most common was nausea (15%). Two patients (4%) discontinued tirzepatide due to side effects.
Conclusion: In adults with T1D, tirzepatide led to significant weight loss, better diabetes control, and lower insulin requirements without causing severe hypoglycemia or DKA over the course of up to 12 months. The side effect profile mimicked what has been reported. These data support the effectiveness and safety of tirzepatide for the treatment of obesity in adults with T1D.

Disclosure
E. Tama: None. D. Bechenati: None. P. Bennett: Stock/Shareholder; Lilly Diabetes. A. McNally: Stock/Shareholder; Medtronic. R. Rivera: None. S. Fansa: None. D. Anazco: None. A. Acosta: Consultant; Amgen Inc., Regeneron Pharmaceuticals Inc., Nestlé Health Science, Structure Therapeutics, Inc., Boehringer-Ingelheim. Research Support; Vivus. Consultant; Currax. Other Relationship; Gila Therapeutics, Phenomix Sciences. Speaker's Bureau; Eli Lilly and Company. M.D. Hurtado: None.

Funding
K12AR084222
1936-LB: The Challenge of Obtaining Diabetes Technology Supplies in Adults with Type 1 Diabetes
Authors: WELCH ANDREW A. , KNOERL THOMAS , KOPRAS ELIZABETH J. , CORATHERS SARAH , FALCIGLIA MERCEDES 
Published: June 2024

Background: Individuals with Type 1 Diabetes (T1D) face barriers to reliably obtain prescribed technology supplies (continuous glucose monitors [CGM]/insulin pump supplies). The frequency of annual supply access interruptions (ASAI) and the associated burden (emotional, financial, time) with this process are unclear.
Objective: To quantify ASAI of technology supplies/insulin and associated burden in adults with T1D.
Methods: A 64-question online survey was distributed to the T1D Exchange registry for US adults with T1D. ASAI was defined as total instances that individuals ran out of CGM, insulin pump supplies, and/or insulin in the past year. The burden to obtain supplies was assessed by a 1-10 scale (10 = strongly agree). Means and SD were reported. Significance of comparisons was assessed with t-tests or ANOVA for parametric data, and Mann-Whitney or Kruskal-Wallis tests for non-parametric data (significant = p&lt;0.05).
Results: Responses were completed by 2151 surveyed. Mean age was 49 years, 73% female, average A1C 6.7%, with 96% and 80% utilizing CGM and insulin pumps respectively. ASAI averaged 1.8 and varied significantly based on gender (Female = 1.9), insurance (Medicaid = 3.9), income (None = 3.23), race (Black = 3.0), and location (Rural = 2.3). Emotional burden (worry about running out of supplies) was significantly higher in women, those without insurance, lower annual income, and non-white race. A 10 was reported for “It is difficult to afford supplies” by 13% and “I spend too much time obtaining supplies” by 11%. Early CGM and insulin pump cannula failures were reported by 45% and 48% of respondents respectively. The top reason for ASAI was “Required prior authorization” in 36% of respondents. The top strategies to avoid ASAI were “Call supply company to request extra supplies” (25.9%), and “Use supply for longer than recommended” (25.5%).
Conclusion: Challenges in obtaining diabetes supplies are significant and disproportionately affect certain socioeconomic groups with T1D.

Disclosure
A.A. Welch: None. T. Knoerl: None. E.J. Kopras: None. S. Corathers: None. M. Falciglia: None.
74-OR: ADA Presidents' Select Abstract: CGM Metrics from Five Studies Identify Participants at High Risk of Imminent Type 1 Diabetes (T1D) Development
Authors: CALHOUN PETER , SPANBAUER CHARLEY , STECK ANDREA , FROHNERT BRIGITTE I. , HERMAN MARK A. , KEYMEULEN BART , VEIJOLA RIITTA , TOPPARI JORMA , DESOUTER ASTER , GORUS FRANS K. , ATKINSON MARK A. , WILSON DARRELL M. , PIETROPAOLO SUSAN , BECK ROY 
Published: June 2024

Introduction & Objective: We assessed if continuous glucose monitoring (CGM) metrics accurately identify imminent stage 3 T1D diagnosis in those with islet autoantibody (IAb) positivity.
Methods: Baseline CGM data were collected from participants with ≥1 positive IAb type from five studies: ASK (N=79), BDR (N=22), DAISY (N=18), DIPP (N=8), and TrialNet (N=91). Median follow-up time was 2.6 y (IQR: 1.5 to 3.6 y). A CGM and baseline factor model and a baseline-only model were compared. CGM model classified participants as low (N=97), medium (N=74), or high (N=47) risk of stage 3 T1D based on &lt;10%, 10-&lt;30%, and ≥30% probability by year 2.
Results: CGM model found % time &gt;140 mg/dL (TA140), area under the curve 140 mg/dL (AUC140), glucose SD, sex, first degree relative, IA2A, and GADA status were more predictive of T1D progression compared to the baseline-only model (C-statistic: 0.76 vs. 0.62). The probability of developing T1D by 2 years was 4%, 17%, and 51% in the low, medium, and high risk groups (Figure). Compared to low risk participants, high risk participants had higher TA140 (median: 10% vs 2%), AUC140 (mean: 2.9 vs. 1.1 mg/dL), and glucose SD (mean: 24 vs. 18 mg/dL).
Conclusion: CGM metrics can help predict T1D progression and classify participant’s risk of impending T1D diagnosis. CGM can be used to better monitor the risk of T1D progression and define eligibility for potential prevention trials.

Disclosure
P. Calhoun: None. C. Spanbauer: None. A. Steck: None. B.I. Frohnert: None. M.A. Herman: Research Support; Eli Lilly and Company. B. Keymeulen: None. R. Veijola: Advisory Panel; Sanofi. J. Toppari: None. A. Desouter: None. F.K. Gorus: None. M.A. Atkinson: None. D.M. Wilson: Advisory Panel; Enable Biosciences, Inc. S. Pietropaolo: None. R. Beck: Consultant; Insulet Corporation. Research Support; Insulet Corporation. Consultant; Tandem Diabetes Care, Inc. Research Support; Tandem Diabetes Care, Inc. Consultant; Beta Bionics, Inc. Research Support; Beta Bionics, Inc., Dexcom, Inc., Bigfoot Biomedical, Inc. Consultant; Novo Nordisk. Research Support; Novo Nordisk, Eli Lilly and Company. Consultant; embecta, Vertex Pharmaceuticals Incorporated, Hagar, Ypsomed AG, Sanofi, Zucara Therapeutics, Sequel.

Funding
JDRF
“Russians’ Favorite Pastime Is Standing in Line”: Frank Whitson Fetter about Trade and Food Situation in Kazan (1930)
Authors: Абилова Р.О. 
Published: June 2024

В статье рассматриваются положение в торговле и продовольственная ситуация в Казани в период реализации первого пятилетнего плана на основе анализа письменных и визуальных источников, созданных американским экономистом Франком Уитсоном Феттером (1899–1991) во время его шестинедельного визита в 1930 г. Будучи опытным экономистом, Феттер использовал разнообразный арсенал инструментов для изучения экономической ситуации в стране: включенное наблюдение, беседы, фото- и киносъемку. Он ежедневно посещал казанские кооперативы и рынки, фиксируя полевые данные и информацию о съемках, а затем на их основе делал подробные записи в дневнике. В настоящее время значительная часть собранных материалов, включающих более 300 фотографий, хранится в Библиотеке редких книг и рукописей им. Дэвида М. Рубенштейна Дюкского университета (США). Особое внимание в них уделено ситуации, сложившейся в торговле Казани: товарному ассортименту, динамике цен, перебоям в государственном снабжении, санитарному состоянию частных рынков и заведений государственно-кооперативной торговой сети, очередям, поведению продавцов и покупателей, а также в сфере потребления – зарплатам, карточной системе, питанию, наличию и качеству одежды и обуви. Феттер стал свидетелем усиливавшегося товарного дефицита и нараставшего недовольства казанцев, формировавшихся на этапе коренного перелома в экономической системе СССР. В статье раскрывается его взгляд на сформировавшуюся ситуацию и приводятся сделанные им фотографии.
The article examines trade and food situation in Kazan during the first five-year plan based on the analysis of written and visual sources created by American economist Frank Whitson Fetter (1899–1991) during his six-week visit in 1930. As a professional economist, Fetter used a wide variety of tools to study the economic situation in the Soviet Union: participant observation, interviews, photography, and filming. He visited Kazan cooperatives and markets daily and recorded field data in his notebooks. Based on them, Fetter made detailed records in his journal. Currently, a significant part of the collected materials, including more than 300 photographs, is kept at David M. Rubenstein Rare Book & Manuscript Library, Duke University (USA). Particular attention in Fetter’s materials is paid to the Kazan trade situation (the behavior of sellers and buyers, queues, range of goods, price dynamics, interruptions in government supply, sanitary condition of private markets and establishments of the state cooperative trading network) and consumers’ status (their salaries, rationing system, food, availability and quality of clothing and footwear). Fetter witnessed the growing shortage of goods and the growing discontent of Kazan citizens during a radical change in the economic system of the USSR. The article reveals his view of the situation and provides photographs taken by him.