bluuebunny/crossref_metadata_2025_split huggingface dataset:
Host and environmental factors influencing respiratory secretion of pro‐wheezing biomarkers in preterm children
Authors: Matías Vanesa , San Feliciano Laura , Fernández Jose E. , Lapeña Santiago , Garrido Estibaliz , Ardura Julio , Soga Maria José , Aragón María Paz , Remesal Ana , Benito Francisca , Andrés Jesús , Centeno Fernando , Marugán Victor , Bachiller Rosario , Bermejo‐Martin Jesus F. 
Published: May 2012

To cite this article: Matías V, San Feliciano L, Fernández JE, Lapeña S, Garrido E, Ardura J, Soga MJ, Aragón MP, Remesal A, Benito F, Andrés J, Centeno F, Marugán V, Bachiller R, Bermejo‐Martin JF. Host and environmental factors influencing respiratory secretion of pro‐wheezing biomarkers in preterm children. Pediatric Allergy Immunology 2012: 23: 441–447.AbstractCytokines are actively secreted by the respiratory mucosa of preterm children and participate in the pathogenesis of wheezing. This study aimed to identify the factors that could potentially influence respiratory secretion of cytokines in these children. A nasopharyngeal aspirate (NPA) was collected from 77 preterm children 1 yr after birth. NPAs from 14 healthy, 1‐yr‐old term children were collected in parallel. 27 cytokines were measured in the NPAs using a multiplex assay. Multivariate stepwise regression analysis with Bonferroni correction evidenced that the variable [daycare attendance] was associated with higher levels of [monocyte chemoattractant protein‐1 (MCP‐1), IL‐6, vascular endothelial growth factor (VEGF), IL‐1β, IL‐10, tumor necrosis factor (TNF)‐α]; [male sex] with higher levels of (MCP‐1, VEGF, and IL‐1β); [smokers at home] was associated with higher levels of MCP‐1 (p < 0.0013). In turn, [prophylaxis with palivizumab] was associated with lower levels of (IL‐6, IL‐7) (p < 0.0013). All these mediators participate in the pathogenesis of asthma and recurrent wheezing. Preterm children secreted higher levels of chemokines (interferon‐gamma inducible protein‐10, macrophage inflammatory protein‐1α, Eotaxin, MCP‐1), growth factors (platelet‐derived growth factor‐bb, VEGF, fibroblast growth factor‐basic, granulocyte macrophage colony‐stimulating factor), Th1 (IL12, interferon‐γ), Th2 (IL‐9, IL‐13), Th17 (IL‐6, IL‐17) cytokines, and immunomodulatory mediators (IL1RA and granulocyte colony‐stimulating factor) than term children. In conclusion, we have identified for the first time a group of individual and environmental factors influencing respiratory secretion of cytokines in preterm children at the long term after birth. To know these factors could help to prevent the instauration of conditions linked to the appearance of chronic respiratory diseases such as wheezing or asthma.
Health‐related quality of life does not explain the protective effect of farming on allergies
Authors: Stöcklin Laura , Loss Georg , von Mutius Erika , Genuneit Jon , Horak Elisabeth , Braun‐Fahrländer Charlotte ,   on behalf of the GABRIELA study group
Published: May 2012

To cite this article: Stöcklin L, Loss G, von Mutius E, Genuneit J, Horak E, Braun‐Fahrländer C. Health‐related quality of life does not explain the protective effect of farming on allergies. Pediatr Allergy Immunol 2012: 23: 519–521.AbstractBackground:  Numerous studies report a protective effect of farming against allergic diseases. Some specific underlying exposures contributing to this effect have recently been described in the GABRIEL survey. So far, psycho‐social factors have not been included in these analyses.Methods:  In order to assess the potential influence of health‐related quality of life (HRQOL) on the protective effect of farming, 8259 school aged children from the European GABRIEL study answered questions concerning farming and allergic diseases, as well as validated questions about HRQOL.Results:  Farm children reported higher HRQOL than non farm children. However, HRQOL did not modify the protective effect of farming against allergies. Children with allergic diseases reported significantly lower HRQOL scores suggesting that the higher HRQOL of farm children was in part explained by the lower prevalence of these diseases among farm children.Conclusion:  Although farm children reported higher HRQOL scores than did non‐farm children, HRQOL did not explain the protective effect of farming against allergic diseases. The relationship between allergic diseases and HRQOL is likely bidirectional and needs to be assessed prospectively.
Few associations between high‐sensitivity C‐reactive protein and environmental factors in 4.5‐year‐old children
Authors: Mustonen Kirsi , Keski‐Nisula Leea , Vaarala Outi , Pfefferle Petra Ina , Renz Harald , Riedler Josef , Dalphin Jean‐Charles , Buechele Gisela , Lauener Roger , Braun‐Fahrländer Charlotte , von Mutius Erika , Pekkanen Juha ,   the PASTURE Study Group
Published: May 2012

To cite this article: Mustonen K, Keski‐Nisula L, Vaarala O, Pfefferle PI, Renz H, Riedler J, Dalphin J‐C, Buechele G, Lauener R, Braun‐Fahrländer C, von Mutius E, Pekkanen J and the PASTURE Study Group. Few associations between high‐sensitivity C‐reactive protein and environmental factors in 4.5‐year‐old children. Pediatr Allergy Immunol 2012: 23: 522–528.AbstractBackground:  Low‐grade inflammation in early childhood might protect from allergic diseases later in life. Our aim was to examine the effects of different environmental factors on low‐grade inflammation measured with serum high‐sensitivity C‐reactive protein (hsCRP) at the age of 4.5 years.Methods:  The high‐sensitivity CRP values (n = 653) and serum‐specific IgE concentrations were measured from 4.5‐year‐old children in rural areas in five European countries (Austria, Finland, France, Germany, and Switzerland). Children belonged to the prospective multi‐center PASTURE birth cohort. Data on early and current farming environment and domestic animal exposure were collected by questionnaires.Results:  Females as well as obese or very obese children at age of 4.5 years had higher hsCRP values than males (aOR 1.84 95% CI 1.27–2.66) and healthy weight children (aOR 4.47 95% CI 1.94–10.31), respectively. Levels were lowest in the summer. Few associations were detected between hsCRP values and farm environmental factors or atopic sensitization. However, there was evidence of children with low levels of hsCRP (below the detection limit) who had increased prevalence of sensitization to inhaled and seasonal allergens. Among non‐sensitized children, spending time in stables was associated with reduced hsCRP (15 min–10 h aOR 0.40 95% CI 0.16–0.96 and ≥10 h aOR 0.25 95% CI 0.07–0.90), and among sensitized children, maternal smoking was associated with higher hsCRP values (aOR 2.51 95% CI 1.12–5.59).Conclusion:  We found few associations between early environmental farming factors and hsCRP levels, and between hsCRP levels and atopic sensitization in 4.5‐year‐old children. However, our results suggest that the role played by the environmental factors in low‐grade inflammation may differ between sensitized and non‐sensitized children.
Primary school teachers’ knowledge about and attitudes toward anaphylaxis
Authors: Ercan Hulya , Ozen Ahmet , Karatepe Hande , Berber Mustafa , Cengizlier Reha 
Published: May 2012

To cite this article: Ercan H, Ozen A, Karatepe H, Berber M, Cengizlier R. Primary school teachers’ knowledge about and attitudes toward anaphylaxis. Pediatr Allergy Immunol 2012: 23: 428–432.AbstractBackground:  One in 10,000 children experiences an anaphylactic attack, every year. It has been demonstrated that 82% of these attacks occur in children of school age and that most of the attack‐related deaths have occurred in schools. In this study, we aimed to investigate primary school teachers’ knowledge about and attitudes toward anaphylaxis.Method:  A total of 237 teachers were questioned: 91 working in elementary state schools and 146 in private schools. A questionnaire was completed to obtain data on their knowledge of anaphylaxis and the availability of emergency treatment facilities in schools.Results:  Fifty‐two percent of the teachers knew which students had an allergic disease. When questioned about agents that can potentially cause anaphylaxis, the most significant causes were thought to be pollen by 54% of the teachers, food by 47%, mites by 40%, and drugs by 30%. Of foods, eggs (30.4%) and strawberries (25.3%) were thought to be the two leading causes. The teachers’ responses on what would be their initial reaction in the event of an anaphylactic reaction were: he/she would give first aid in 24.3%, notify the school nurse in 39.7%, and call the emergency services in 19.8%. Only 10% were aware of an epinephrine autoinjector, and only 4% knew where to apply it. While 28% of the teachers reported that they had been informed about anaphylaxis previously, most had formed their ideas from brochures or the media. While 25% of the teachers knew all of the symptoms of anaphylaxis, 54% knew some, and 21% none. Only 6% of the teachers reported that there was a management plan for anaphylaxis in their schools.Conclusion:  This study shows that primary school teachers are not well informed about anaphylaxis. Teachers should be given training on the subject, and there should be a re‐evaluation of school and health policies with a wider global perspective. There is an urgent need to inquire into the allergy management plans and policies in schools and to develop teacher education organizations on the subject.
Relationship between rhinitis and nocturnal cough in school children
Authors: Higuchi Osamu , Adachi Yuichi , Itazawa Toshiko , Ito Yasunori , Yoshida Koichi , Ohya Yukihiro , Odajima Hiroshi , Akasawa Akira , Miyawaki Toshio 
Published: May 2012

To cite this article: Higuchi O, Adachi Y, Itazawa T, Ito Y, Yoshida K, Ohya Y, Odajima H, Akasawa A, Miyawaki T. Relationship between rhinitis and nocturnal cough in school children. Pediatr Allergy Immunol 2012: 23: 562–566.AbstractBackground:  There is a complex relationship between rhinitis, asthma, and nocturnal cough.Methods:  To evaluate whether rhinitis is an important risk factor for nocturnal cough and whether this effect is independent of asthma, we analyzed data collected using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire in a population‐based nationwide survey. A child who had experienced a dry cough at night in the past 12 months in the absence of a cold was defined as having nocturnal cough.Results:  After excluding 11,475 records with incomplete data, data from 136,506 children were analyzed. Nocturnal cough was significantly more prevalent in children with current rhinitis compared with children without rhinitis. The association between rhinitis and nocturnal cough was significant in children who had current asthma (adjusted OR [95% CI]: 2.26 [2.00–2.56] in children aged 6–7 yr, 1.90 [1.58–2.30] in those aged 13–14 yr, and 1.86 [1.60–2.19] in those aged 16–17 yr), and this association was even higher among children who had no asthma (adjusted OR [95% CI]: 3.65 [3.36–3.97] in children aged 6–7 yr, 3.05 [2.79–3.32] in those aged 13–14 yr, and 2.69 [2.51–2.88] in those aged 16–17 yr).Conclusions:  There was a close association between rhinitis and nocturnal cough in young children through adolescents, and this effect was independent of asthma. Upper airways should be examined in children with nocturnal cough.
Parent perceived quality of life is age‐dependent in children with food allergy
Authors: Wassenberg Jacqueline , Cochard Marie‐Madeleine , DunnGalvin Audrey , Ballabeni Pierluigi , Flokstra‐de Blok Bertine M. J. , Newman Christopher J. , Hofer Michael , Eigenmann Philippe A. 
Published: May 2012

To cite this article: Wassenberg J, Cochard M‐M, DunnGalvin A, Ballabeni P, Flokstra‐de Blok BMJ, Newman CJ, Hofer M, Eigenmann PA. Parent perceived quality of life is age‐dependent in children with food allergy. Pediatr Allergy Immunol 2012: 23: 412–419.AbstractBackground:  Food allergy in children significantly affects their quality of life. Its impact can be analyzed by quality of life questionnaires.Objectives:  The aim of our study was to validate the French version of disease‐specific questionnaires and to evaluate the quality of life in children with IgE‐mediated food allergy.Methods:  Two validated food allergy‐specific questionnaires for quality of life, the parent’s and children’s forms (FAQLQ‐PF and FAQLQ‐CF), were translated from English to French and submitted to children with food allergy and their parents. Questionnaires were analyzed in terms of emotional impact, food anxiety, and social and food limitations. NCT 01480427.Results:  Sixty‐two parents of children aged 0–12 yrs answered the FAQLQ‐PF, and 32 children aged 8–12 yrs the FAQLQ‐CF. Construct validity of both questionnaires was assessed by correlation between the FAQLQs and FAIM (r = 0.85 and 0.84, respectively). Both FAQLQs had good internal consistency (Cronbach’s α = 0.748 and 0.67, respectively). Young children (0–3 yrs old) showed better quality of life scores than older children (FAQLQ‐PF global score: p = 0.02). Worse scores were also shown among children with previous severe systemic reactions (FAQLQ‐PF global score: p = 0.039), the ones with an allergic mother (FAQLQ‐PF global score: p = 0.002), or allergic siblings (FAQLQ‐PF emotional impact score: p = 0.034), the ones with multiple food allergy (more than 1 food) (FAQLQ‐PF anxiety score: p = 0.04) and among the girls (FAQLQ‐CF global score: p = 0.031).Conclusion:  Older children, the ones with severe systemic reactions, or with mothers or siblings also affected by allergies, as well as girls, and children with multiple food allergies show worse quality of life scores.
Fibroblast growth factor 23 and calcium phosphate homeostasis after pediatric renal transplantation
Authors: van Husen Michael , Lehnhardt Anja , Fischer Ann‐Katrin , Brinkert Florian , Loos Sebastian , Oh Jun , Kemper Markus J. 
Published: May 2012

van Husen M, Lehnhardt A, Fischer A‐K, Brinkert F, Loos S, Oh J, Kemper MJ. Fibroblast growth factor 23 and calcium phosphate homeostasis after pediatric renal transplantation.Abstract:  FGF23 is a circulating factor regulating TPR and is increased in CKD. After RT, it seems to induce phosphorus wasting in adults. Data on FGF23 after PRT are scarce. Parameters of bone metabolism including calcium, phosphate, 25‐(OH) vitamin D, 1,25‐(OH)2 vitamin D, alkaline phosphatase, PTH, and FGF23 were analyzed in 57 children after PRT and 11 controls. Median time after PRT was 25.9 (range 2–135) months. eGFR after PRT ranged from 15 to 175 mL/min/1.73 qm. Mean (±s.e.) FGF23 and PTH levels were significantly elevated compared with controls (146 ± 30 vs. 43 ± 3 ng/L, p = 0.001 and 182 ± 42 vs. 74 ± 18 ng/L, p = 0.004, respectively). Highest FGF23 levels were found in children with an eGFR below 60 mL/min*1.73 sqm (280 ± 69 vs. 62 ± 5 ng/L, p = 0.001), but significantly elevated values were already present in CKD2T. In a multivariate analysis, eGFR, PTH, calcium, and phosphate were significantly associated with FGF23. In a subgroup of 17 patients (29.8%) with persistent hypophosphatemia, phosphate levels were significantly associated with FGF23 and not with PTH. FGF23 is increased in children after PRT, especially in patients with chronic allograft dysfunction, and seems to be a more sensitive marker of dysregulated calcium phosphate homeostasis than PTH.
Routine transplant Doppler ultrasonography following pediatric kidney transplant
Authors: Bou Matar Raed , Warshaw Barry , Hymes Leonard , Greenbaum Larry A. 
Published: May 2012

Bou Matar R, Warshaw B, Hymes L, Greenbaum LA. Routine transplant Doppler ultrasonography following pediatric kidney transplant.Abstract:  The utility and cost‐effectiveness of routine transplant renal DU as a screening test in the immediate postoperative period following pediatric renal transplantation has not been systematically evaluated. Our center’s transplant protocol includes a routine DU on postoperative day 3, unless an earlier DU was obtained for a specific indication. We retrospectively evaluated 113 consecutive pediatric renal transplant recipients. Indication for DU (routine vs. non‐routine), timing, results, and graft outcome data were collected. We determined whether the DU result affected patient management. Eighty routine DU examinations were evaluated. Thirty (37.5%) of the 80 routine DUs had abnormalities. Most abnormalities were minor and did not require intervention. One patient with a dysfunctional bladder had mild hydronephrosis; this led to a decision to increase the frequency of bladder catheterization. This was the only intervention based upon the routine DUs. Twenty percent of routine DUs revealed abnormalities that led to a follow‐up study, but none of these studies led to an intervention. The incremental cost of each DU exceeded $1080 and the incremental cost‐effectiveness ratio for a documented change in management exceeded $86 400. Our results suggest that routine post‐transplant DU is not cost‐effective in pediatric renal allograft recipients.
Association between the CD209 promoter −336A/G polymorphism and susceptibility to tuberculosis: A meta‐analysis
Authors: MIAO RUIFEN , LI JIEQUAN , SUN ZHAOPING , LI CHEN , XU FEI 
Published: May 2012

ABSTRACTBackground and objective:  Dendritic cell‐specific intracellular adhesion molecule‐3 grabbing nonintegrin (DC‐SIGN), encoded by the CD209 gene, is a major Mycobacterium tuberculosis receptor on human dendritic cells. The potentially functional −336A/G polymorphism in the CD209 promoter region has been associated with susceptibility to tuberculosis (TB), but the results have been inconclusive. We performed a meta‐analysis to clarify the relationship between the CD209−336A/G variant and the risk of TB.Methods:  Ten studies involving a total of 2598 TB patients and 2614 control subjects were systematically reviewed, and the data were quantitatively synthesized by meta‐analysis. The Q‐test was applied to assess the heterogeneity of associations among the studies, and Egger's regression test was used to assess potential publication bias.Results:  No significant association was identified between the CD209−336A/G polymorphism and risk of TB (G allele vs A allele: odds ratio (OR) 1.02, 95% confidence interval (CI) 0.90–1.15). Moreover, no significant association was observed in populations of African ethnicity (OR 1.01, 95% CI 0.87–1.17) or among individuals who were negative for the human immunodeficiency virus (OR 0.98, 95% CI 0.84–1.15).Conclusions:  This meta‐analysis has indicated that the CD209−336A/G polymorphism may not contribute to susceptibility to TB.
Sleep‐disordered breathing in children with Chiari malformation type II and myelomeningocele
Authors: Alsaadi Muslim M. , Iqbal Shaikh M. , Elgamal Essam A. , Gozal David 
Published: May 2012

AbstractBackground:  The prevalence of sleep‐disordered breathing (SDB) in children with Chiari malformation type II (CM‐II), a known association of neural tube defects (NTD), has not been well documented. The aim of the present study was to assess the prevalence and possible predictive factors of SDB in patients with CM‐II.Methods:  The study included all patients with documented CM‐II who were routinely referred from the Neurosurgery Clinic to the University Sleep Disorders Centre at King Khalid University Hospital, Riyadh, Saudi Arabia, between January 2002 and July 2009. Overnight full polysomnography (PSG) was performed in all patients. Polysomnographic data were analyzed using descriptive statistics.Results:  Sixteen children (11 boys, five girls) were included in the study; their mean age was 4.7 years (range, 0.8–10 years) and their mean body mass index was 18.05 kg/m2 (range, 15.4–25.4 kg/m2). For the whole group, the mean apnea–hypopnea index (AHI) was 6.3/h (range, 0.2–24.5/h), with AHI recorded as >5/h in five patients (31.3%) and ≥10/h in three patients (18.8%). The mean central apnea–hypopnea index was 5.9/h (range, 0–24.5/h) and the mean obstructive apnea–hypopnea index was 0.4/h (range, 0–2.9/h). The mean arousal index was 15.1/h (range, 5–34/h).Conclusion:  The major assumption linking CM‐II and NTD with potential brainstem compression and respiratory dysfunction during sleep was confirmed. Indeed, SDB is highly prevalent, and clearly underreported and undertreated in patients with CM‐II associated with NTD.
Leadership, support and acknowledgement of registered nurses work in acute mental health units
Authors: Cleary Michelle , Horsfall Jan , O'Hara‐Aarons Maureen , Hunt Glenn E. 
Published: May 2012

ABSTRACTIn acute mental health inpatient units, it is not surprising that culture, peers, immediate management, and sources of support and acknowledgment all contribute to positive nursing outcomes. In this qualitative study, four questions targeting leadership, culture, support, and acknowledgement of work well done were asked of 40 registered nurses (RN) working in acute mental health units. Findings convey a mixed picture indicating variation across units. Three‐quarters believe that senior nursing staff actively contribute to a positive working environment. Almost half of the RN nominated peers as the providers of counsel and support when required, and a similar percentage believed that senior nursing staff fulfil these roles. Of interviewees, 33% said their nursing achievements are never, or rarely, acknowledged. For these RN, management, peers, and nurse unit managers are the preferred personnel to provide appropriate positive feedback. Thus, there is a gap between the expectations and hopes that nurses have for senior management approaches and behaviours and the reality of their daily experience. Overall, the responses portray a culture that underpins and enables both subtle interpersonal interactions that might arise out of necessity given the perceived lack of support from non‐hands‐on RN and administrators.
Capsicum plasters on acupoints decrease the incidence of emergence agitation in pediatric patients
Authors: Acar H. Volkan , Yilmaz Ahmet , Demir Gamze , Günal Eruyar Solmaz , Dikmen Bayazit 
Published: May 2012

SummaryAim:  To detect the effect of capsicum plasters on bilateral HT 7 acupoints for decreasing Emergence agitation (EA) in pediatric patients undergoing tonsillectomy and/or adenoidectomy.Background:  Emergence agitation with its incidence of 10% to 80% may have deleterious effects in postoperative period. Children may harm themselves and/or care providers who require extra nursing care and additional sedatives and/or analgesics that may cause a delay in discharge from hospital. The studies dealt with the potential benefits of the use of adjuvant drugs have yielded controversial results. Some may have side effects as well as the absence of a positive effect on EA.Methods/Materials:  Fifty patients undergoing elective adenoidectomy and/or tonsillectomy who aged between 2 and 10 were included to the study. Patients were divided into two groups, and capsicum plasters (acupuncture) or inactive plasters (sham) were applied on bilateral HT 7 points preoperatively. Pain, emergence agitation, and side effects were evaluated for 15 min postoperatively.Results:  Incidence of EA (PAED scale) (28.0% vs 60.0) and postoperative side effects was lower in acupuncture group than in sham group while there was no significant difference in the severity of EA between groups. Duration of recovery was shorter in acupuncture group. Pain scores (CHEOPS scale) were comparable between groups. EA patients were noted to have greater age and more retching than non‐EA patients. Postoperative side effects such as retching, laryngospasm, and vomiting were seen more frequently in the patients with EA.Conclusions:  Application of capsicum plasters on acupoints offers a valuable choice in the prevention of EA in children.