bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring novel peptides in adzuki bean and mung bean hydrolysates with potent antibacterial activity
Authors: Karami Zohreh , Muangnapoh Chonchanok , Suthienkul Orasa , Suriyarak Sarisa , Duangmal Kiattisak 
Published: May 2024

SummaryThis study delved into the antimicrobial potential of hydrolysates from adzuki bean and mung bean protein concentrates, created using Alcalase and Flavourzyme enzymes. Targeting common foodborne pathogens (Salmonella Typhimurium, Salmonella Enteritidis, Vibrio parahaemolyticus, Staphylococcus aureus, and Bacillus subtilis) and Escherichia coli, the research underscored the crucial role of peptidase in generating antibacterial peptides. Fractions F2 of Flavourzyme hydrolysed adzuki bean (ABF) and F4 of Flavourzyme hydrolysed mung bean (MBF) showed the highest antibacterial activity against S. Typhimurium and S. aureus, respectively, whereas F2 of Alcalase hydrolysed mung bean (MBA) exhibited very poor activity against S. aureus. TripleTOF LC–MS/MS analysis revealed small cationic antibacterial peptides, with lysine being prominent against S. aureus and proline–proline against S. Typhimurium. These findings highlighted the significant contribution of protease enzymes in fostering antibacterial peptide production, offering valuable insights for developing effective antimicrobial agents in the context of food safety.
Harnessing artificial intelligence in microbial food safety: global progress and implications in the ASEAN region
Authors: Panaligan Dominic , Sy Isaac Cornelius Bensley , Sarza Riann Martin 
Published: May 2024

SummaryFood safety remains one of the major concerns in ASEAN, with many of the recent developmental plans and published policies in the region being focused on the topic. Most recent WHO data indicate that over 90% of the food safety burden in ASEAN is due to microbial foodborne diseases. However, conventional systems for controlling FBDs are resource‐intensive and require significant infrastructure which may not yet be present in ASEAN. Prior work on the use of Artificial intelligence (AI) in food safety application has shown its potential to reduce costs and increase efficiency. However, there remains a paucity in such research specific for the ASEAN region. In this review, the state of microbial food safety and the unique challenges in the ASEAN region are presented. The global state‐of‐the‐art of microbial food safety applications of AI are presented and possible steps for its adaptation to the ASEAN context are then discussed.
Lifestyle‐based subtypes of childhood obesity and their association with cardiometabolic factors: A cluster analysis
Authors: Huang Jia‐Shuan , Ramakrishnan Rema , Liu Quan‐Zhen , Wang Cheng‐Rui , Shen Song‐Ying , Huang Ming‐Xi , Wei Xue‐Ling , Qiu Xiu , He Jian‐Rong 
Published: May 2024

SummaryBackgroundLifestyle factors play an important role in the development and management of childhood obesity and its related cardiometabolic complications.Objective/MethodsWe aimed to explore childhood obesity subtypes based on lifestyle factors and examine their association with cardiometabolic health. We included 1550 children with obesity from the National Health and Nutrition Examination Survey. Cluster analysis identified obesity subtypes based on four lifestyle factors (physical activity, diet quality, sedentary time and smoking). Multiple linear regression assessed their association with cardiometabolic factors.ResultsFive subtypes of childhood obesity were identified: unhealthy subtype (n = 571; 36.8%), physically active subtype (n = 185; 21.1%), healthy diet subtype (n = 404; 26.1%), smoking subtype (n = 125; 8.1%) and non‐sedentary subtype (n = 265; 17.1%). Compared with the unhealthy subtype, the physically active subtype had lower insulin and HOMA‐IR levels, and smoking subtype was associated with lower HDL levels. When compared with children with normal weight, all obesity subtypes had worse cardiometabolic profile, except the physically active subtype who had similar DBP, HbA1c and TC levels; smoking subtype who had similar TC levels; and healthy diet and non‐sedentary subtypes who had similar DBP levels.ConclusionChildren of different lifestyle‐based obesity subtypes might have different cardiometabolic risks. Our new classification system might help personalize assessment of childhood obesity.
Impact of foot ulcer‐related factors on quality of life in patients with diabetes: Prospective observational study
Authors: Oe Makoto , Saad Supriadi Syafiie , Jais Suriadi , Sugama Junko 
Published: May 2024

AbstractQuality of life (QOL) may be impacted by foot ulcer‐related factors, with prevention of diabetes‐related foot ulcers or more effective early healing helping to improve overall patient QOL. This study, which examined the relationship between foot ulcer‐related factors and QOL in patients with diabetes, was conducted as a secondary analysis of a prospective observational study entitled: “Factors associated with the discontinuation of wound care specialist clinic visits in patients with diabetic foot ulcers”. We investigated EQ‐5D‐5L, patient characteristics and foot ulcer‐related factors of 73 patients with diabetes‐related foot ulcers who visited one wound clinic in Indonesia between August 2020 and February 2021. Results showed that the mean health utility was 0.294 ± 0.371. Factors selected for the multiple regression analysis included inflammation/infection of DMIST, first‐ever foot ulcer, and size of DMIST. First‐ever foot ulcer (β = 0.309, p = 0.003) and size of DMIST (β = −0.316, p = 0.015) were significantly associated with the health utility (p < 0.001). Significant improvement in the health utility of 15 patients was observed when the ulcer healed (Wilcoxon signed‐rank sum test, p = 0.001). In conclusion, not only ulcer severity but also the first‐ever foot ulcer itself affected the QOL in patients with diabetes. These results suggest there will be a greater impact on the QOL of patients who develop diabetes‐related foot ulcers for the first time, along with the importance of prevention and early healing, through early infection control and wound size reduction.
‘Nutrition has everything to do with wound healing’—health professionals' perceptions of assessment and management of nutrition in individuals with diabetes‐related foot ulceration
Authors: Donnelly Hailey R. , Clarke Erin D. , Collins Clare E. , Tehan Peta E. 
Published: May 2024

AbstractDetermine how healthcare professionals perceive their role in nutrition assessment and management, and explore barriers and enablers to assessment and management of nutrition in individuals with DFU. Mixed methods including a cross‐sectional online survey derived from current international guidelines and theoretical domains framework, and semi‐structured interviews with conventional content analysis was performed. One hundred and ninety‐one participants completed the survey, with 19 participating in interviews. Many health professionals are not confident in their ability in this area of practice, are uncertain their nutrition advice or management will be effective in assisting wound healing outcomes and are uncertain their intervention would result in adequate behaviour change by the individual with DFU. Major barriers to implementation of nutrition assessment and management were: inadequate time, lack of knowledge and lack of clinical guidance and enablers were as follows: professional development, a standardised clinical pathway and screening tool and a resource addressing wound healing and diabetes management. Nutrition assessment and management in individuals with DFU is not consistently applied. Whilst health professionals believed nutrition was important for wound healing, they lacked confidence in implementing into their practice. Further dissemination of existing guidance and implementation of education programs and resources would help overcome cited barriers.
A clinical study of the local injection of a freshly manufactured 35 kDa hyaluronan fragment for treating chronic wounds
Authors: Treger Dylan , Zhang Lujia , Jia Xiaoxiao , Hui Jessica H. , Gantumur Munkh‐Amgalan , Hui Mizhou , Liu Li 
Published: May 2024

AbstractThis study manufactured a 35 kDa hyaluronan fragment (HA35) by enzymatically degrading high‐molecular‐weight HA using hyaluronidase PH20 derived from bovine testis. The research then examined the therapeutic efficacy of locally administered, tissue‐permeable HA35 in alleviating chronic wounds and their associated neuropathic pain. For 20 patients with nonhealing wounds and associated pain lasting over three months, 100 mg of HA35 was injected daily into the healthy skin surrounding the chronic wound for 10 days. Self‐assessments before and after treatment indicated that HA35 significantly enhanced wound healing. This was evidenced by the formation of fresh granulation tissue on the wounds (p < 0.0001); reduced darkness, redness, dryness, and damage in the skin surrounding the wounds (p < 0.0001), and a decrease in wound size (p < 0.001). Remarkably, HA35 injections alleviated pain associated with chronic wounds within 24 hours (p < 0.0001). It can be concluded that the low‐molecular‐weight hyaluronan fragment HA35 potentially enhances the immune response and angiogenesis during wound healing.
Postsynthetic modification of yttria‐stabilized zirconia aerogels with silica coatings for enhanced thermal stability
Authors: Olson Nathaniel S. , Stokes Jamesa L. , Guo Haiquan , Hurwitz Frances I. , Rogers Richard B. , Shah Nachiket , Krogstad Jessica A. 
Published: May 2024

AbstractMaintaining high surface area and porosity at high temperatures is important when considering aerogels for use in thermal management systems. The mesoporous structure of aerogels results in extremely low thermal conductivity, making them lightweight, high performance insulating materials. Maintaining these properties requires innovative routes to suppress sintering and pore collapse as use temperatures rise. The current work aims to improve the pore structure stability of yttria‐stabilized zirconia aerogels by the addition of a SiO2 coating. The functionalization of surface hydroxyl groups by the addition of SiO2 is hypothesized to mitigate condensation reactions, which are a driving force for shrinkage and pore structure collapse. Zirconia aerogels with 0, 10, and 30 mol% yttria (YO1.5) additions were coated in a tetraethyl orthosilicate (TEOS) solution and exposed to temperatures up to 1200°C. Crystal structure, pore structure, and aerogel morphology were investigated to understand changes in aerogel thermal stability. The SiO2 coating exhibited a greater influence on pore stability over yttria concentration, with specific surface area of the coated aerogels being twice that of the uncoated aerogels up to 1000°C. However, the presence of the SiO2 coating promoted rapid sintering and densification at 1200°C, establishing an upper use temperature for SiO2 and a need to develop other coating chemistries.
The (dis)organization of leg ulcer care: A realist synthesis
Authors: Pagnamenta Fania , Lhussier Monique , Rapley Tim 
Published: May 2024

AbstractBackgroundVenous leg ulcers affect 1.5% of the UK adult population. Leg ulcers are painful, can be malodourous and are associated with poor quality of life. Leg ulcers are predominantly cared for by nurses in the community. Frequently, patients receive suboptimal treatment through unwanted variations in care and simple ulcers deteriorate to become hard‐to‐heal wounds. It is important to understand the current UK system of care and how nurses and patients navigate through it.AimThe aim of this paper was to understand how, when, for whom and in what context leg ulcers are cared for in the United Kingdom and specifically, the current system of care, the nurses' role and the patients' experience in this system of care.DesignA realist synthesis of the literature was undertaken, reported following the RAMESES publication standards: Realist syntheses.Data SourcesAn iterative literature search was conducted across three recognized health collections from January 2010 to January 2022 that included descriptive studies as well as primary research.Results73 papers were included.ConclusionIn the absence of UK national guidance that recommends how leg ulcer care is organized and delivered, care is commissioned locally, with variable outcomes. Patients with venous leg ulcers would like to be looked after by knowledgeable, skilled and confident nurses, in well‐equipped and staffed clinics; nurses who have the ability to make clinical judgements to alter their treatment when necessary and are empowered to refer to specialist centres when further support is required.Implications for the Profession and/or Patient CareThis synthesis offers guidance to commissioners and providers to change how leg ulcer care is organized.Patient or Public ContributionThe views of a patient and public group was sought at each stage of the synthesis.
The physical, social, and mental conditions of machine learning in student health evaluation
Authors: Tyulepberdinova Gulnur , Mansurova Madina , Sarsembayeva Talshyn , Issabayeva Sulu , Issabayeva Darazha 
Published: May 2024

AbstractBackgroundThis study aims to assess how well several machine learning (ML) algorithms predict the physical, social, and mental health condition of university students.ObjectivesThe physical health measurements used in the study include BMI (Body Mass Index), %BF (percentage of Body Fat), BSC (Blood Serum Cholesterol), SBP (Systolic Blood Pressure), and DBP (Diastolic Blood Pressure).MethodsThe mental health evaluation relied on the following methods: PHQ‐9 (Patient Health Questionnaire‐9), ISI (Insomnia Severity Index), GAD‐7 (Generalized Anxiety Disorder Scale), and SBQ‐R (Suicidal Behaviors Questionnaire‐Revised). The study assessed KEYES, the comprehensive social health indicator. The study uses a famous methodology for training and testing four well‐known ML algorithms, namely the K‐nearest neighbors algorithm, decision trees, Naïve Bayes, and the random forest algorithm.Results and ConclusionsThe recall value of the RF algorithm is higher by 2.0%, 4.15%, and 11.25%, respectively. The F‐score value of the RF algorithm is also the highest. The differences amount to 4.56% (Naïve Bayes), 2.50% (DT), and 11.20% (K‐NN). Accuracy, Precision, Recall, and F‐score were used to assess the researched ML algorithms' prediction ability. With a 99.40% prediction accuracy, a 97.60% precision, a 99.30% recall, and an F‐score value of 98.70%, the Random Forest method performed the best. ML algorithms can serve as tools for the prediction of physical, mental, and social health state of patients, including students, but they have a rather narrow scope of application and do not cover all aspects of health.
Reassessing Cohesion Policy Through the Lens of the New EU Industrial Policy
Authors: Molica Francesco 
Published: May 2024

AbstractThe research note explores the role of cohesion policy in the emerging EU industrial agenda with the view to anchor it in the new industrial policy paradigm. The first part discusses the historical evolution of EU industrial policy and presents the main features of the conceptual perspective loosely referred to as ‘new industrial policy’. Then, the note investigates the main tensions between cohesion policy's rationales and instruments and the new industrial policy perspective, for instance in relation to the use of experimentation and directionality, and outlines pathways to address them through different lines of research. In conclusion, the note discusses positive avenues to tackle the identity crisis facing cohesion policy thanks to the new industrial policy perspective.
Evaluation of minimally invasive esthetic crown lengthening using an open flap versus flapless surgical approach: A randomized controlled clinical trial
Authors: Sourour Marie‐line , Tawfik Omnia Khaled , Hosny Manal , Fawzy El‐Sayed Karim Mohamed 
Published: May 2024

AbstractObjectivesEsthetic crown lengthening (ECL) is commonly advocated to treat patients with altered passive eruption (APE). Since the introduction of the minimally invasive surgical concept, a limited number of studies have investigated this technique in a standardized manner, with further studies required to verify the validity and predictability of the minimally invasive FL‐technique. The current randomized trial compares a minimally invasive (ECL), using piezosurgery with flapless‐approach (FL), versus an open‐flap (OF) approach in the management of patients with APE Type 1B.Materials and MethodsTwenty‐four patients diagnosed with APE Type 1B were randomly assigned into test (FL) with tunneling approach or control (OF) group with minimally invasive flap reflection (n = 12/group). Postoperative pain was assessed during the first 48 h. Gingival margin (GM) level relative to a custom‐made stent (rGM) and patient satisfaction were assessed preoperative, immediately after surgery, at 3 and 6 months postsurgically. Postoperative swelling was reported for the first week postsurgically. Plaque index (PI), bleeding on probing (BoP), clinical attachment level (CAL), pocket depth (PD) and pink esthetic score (PES), were evaluated at baseline and 6 months. Linear regression analysis was conducted for pain.ResultsOF‐group reported significantly higher pain and swelling scores than FL‐group during the first 48 h (p < 0.05). FL‐group showed no significant differences regarding rGM between 3 and 6 months, in contrast to OF‐group, where a significant decrease in rGM was notable (p < 0.05). No significant differences in PI, BoP, CAL, PD, PES, and patient satisfaction scores were evident between groups (p > 0.05). Regression analysis demonstrated that treatment and gender were significant predictors for pain (p < 0.05).ConclusionsWithin the current study's limitations, piezo‐surgical ECL with FL‐approach presented significantly lower postoperative pain, swelling, and early GM stability compared to OF‐approach.Clinical SignificancePiezosurgical ECL with a FL‐approach can be considered a predictable technique with advantages over the OF‐approach in the management of patients with APE Type1B.
Fast and simultaneous detection of wheat kernel adulteration using hyperspectral imaging technology and deep convolutional neural network
Authors: Zhu Jingwu , Rao Zhenhong , Ji Haiyan 
Published: May 2024

AbstractIn this study, hyperspectral imaging technology combined with a novel convolution neural network was utilized to detect wheat kernels adulteration. Two groups of wheat kernels were used as samples in this study. Sound wheat kernels from various varieties were in one group, while unsound wheat kernels of the same variety were in another. Hyperspectral images collected from these two groups of wheat kernels were preprocessed using a series of commonly used methods. Following the collection of hyperspectral data, a method of separating and recombining individual wheat kernels from entire hyperspectral images was applied to create training sets and validation sets. Subsequently, a series of tests were carried out to verify whether the proposed model Following that, a number of experiments were conducted to confirm if the suggested model was effective in simultaneously detecting adulterated wheat kernels, and the results gave a positive conclusion. Finally, accuracy, precision, recall and F1‐scores were used as indicators to evaluate the performance of the proposed models on the test set. As the results demonstrated, satisfactory performance in detecting adulteration of the two groups of wheat kernels was obtained by the proposed model. According to the results, the proposed model combined with HSI technology has a good prospect of being used as an efficient method for detecting wheat kernels adulteration.
Decontamination of egg‐associated pathogens by plasma‐activated water and hydrogen peroxide
Authors: Nasiru Mustapha Muhammad , Boateng Evans Frimpong , Umair Muhammad , Alnadari Fawze , Bassey Anthony Pius , Qian Jing , Yan Wenjing , Li Chunyang , Zhang Jianhao 
Published: May 2024

AbstractThis study investigated the effectiveness of plasma‐activated water (PAW) and plasma‐activated hydrogen peroxide (PAHP) in reducing egg‐associated pathogens. The antimicrobial activity of these solutions against Salmonella Enteritidis, Campylobacter jejuni, and Staphylococcus aureus on eggs was evaluated at different plasma treatment durations. The results demonstrated that increasing the duration of plasma treatment enhanced the antimicrobial efficacy of both PAW and PAHP. The bacterial counts of the egg‐associated pathogens significantly decreased from 7.61, 7.59, and 7.54 log (CFU/egg) to 5.4 and 3.09, 5.36 and 3.11, and 5.08 and 3.73 log (CFU/egg) for PAW and PAHP, respectively. The characteristics of the plasma solutions, including electrical conductivity, pH, H2O2, NO3¯, and NO2¯, synergistically acted as antimicrobial agents in both PAW and PAHP treatments. The storage study revealed that PAHP treatment had no adverse effects on the eggs' pH, albumen and yolk color, Haugh unit, and yolk index. However, it did result in reduced eggshell strength and compromised cuticle integrity. Overall, this study demonstrates the successful application of PAW and PAHP in effectively inhibiting egg‐associated pathogens while preserving essential egg quality attributes. Further research is needed to optimize the treatment conditions and investigate the long‐term effects of PAW and PAHP on eggs in larger‐scale applications. This research contributes to developing innovative and sustainable approaches for enhancing the safety and quality of eggs in the food industry.
A mixed‐methods exploration of autonomy‐supportive parenting, confidence, and natural mentoring relationships among Black adolescents
Authors: Charity‐Parker Bianka M. , Billingsley Janelle T. , Deutsch Nancy L. , Hurd Noelle M. 
Published: May 2024

AbstractThe current study examined whether autonomy‐supportive parenting practices may be associated with Black adolescents' quantity of natural mentors (i.e., adults from youths' everyday lives who youth go to for support and guidance) via adolescents' confidence. This study employed survey data from 216 Black youth and qualitative interviews from a subsample of youth (n = 25), their primary caregivers (n = 25), and one nonparental adult relative with whom the youth reported feeling close (n = 25). Comparative analyses were then completed among a subset of 10 family triads corresponding to youth from the qualitative subsample who had the highest (n = 5) and the lowest (n = 5) scores on a survey measure of adolescents' confidence. Study findings suggest that Black adolescents' confidence may be an explanatory link in the association between autonomy‐supportive parenting practices among primary caregivers and Black adolescents' quantity of natural mentoring relationships. Moreover, we found that a range of autonomy‐supportive parenting practices may be associated with youth confidence, which may, in turn, inform how Black adolescents engage with adults in their social networks.