bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Pregnancy after Heart‐Lung Transplantation: A Case Report
Authors: Chinayon Pratharn , Sakornpant Pantpis 
Published: August 2010

AbstractA successful pregnancy outcome in a patient with previous heart‐lung transplantation is reported. A 22‐year‐old primigravid woman received heart‐lung transplantation for Eisenmenger's ASD and conceived 22 months postoperatively. She had been continuously treated with cyclosporine, azathioprine and prednisone during pregnancy. Her antenatal course was uneventful. At 39 weeks' gestation, she developed leakage of amniotic fluid and went into spontaneous labor. She vaginally delivered a 2,550 g male infant by elective forceps extraction, with Apgar scores of 8 and 9 at 1 and 5 minutes, respectively. Mother and baby had an uneventful postpartum course.
A Prospective Study of the Treatment of Cervical Intraepithelial Neoplasia by Loop Electrosurgical Excision Procedure (LEEP) in Hong Kong Population
Authors: Wong Shu Pong , Fung Yun Mei Hedy , Wong Wu Shun Felix 
Published: August 2010

AbstractFrom May to December 1990, 72 patients suffering from cervical intraepithelial neoplasia confirmed with guided biopsy were treated with loop electrosurgical excision procedure (LEEP) as outpatients under local anaesthesia. Overall success rate of a single treatment at 6 weeks follow‐up was 88.9%. All the specimens obtained from the procedure were of good quality for histological examination. The overall significant complication rate of the procedure was 4.2% during treatment and 8.4% after treatment. The results suggested that LEEP is an effective and safe outpatient treatment for CIN lesions. It is easy to use and readily acceptable to patients. It also has the advantage of providing histological confirmation and more economical than the use of laser.
Choriocarcinoma in a Term Placenta with Pulmonary Metastasis
Authors: Kodama Shoji , Yoshiya Norio , Honma Shigeru , Yasuda Masahiro , Ikarashi Hirokazu , Tanaka Kenichi 
Published: August 2010

AbstractThis is a case report of choriocarcinoma in the placenta of a patient who had a term delivery at the 38th week of pregnancy. The pregnant woman had hemoptysis at the 26th week of pregnancy, and a chest X‐ray revealed a tumor in the left lung. She had suffered from a hydatidiform mole in a previous pregnancy in 1989. The patient's serum level of β‐human chorionic gonadotropin (hCG) had been below the normal level before the present pregnancy. Choriocarcinoma was histologically found at 3 sites in the placenta. Her urine hCG levels decreased rapidly after delivery. A partial lobectomy was performed after 2 courses of chemotherapy, and no choriocarcinoma was recognized histologically, because the lesions were hemorrhagic and necrotic. At present, the mother is free of disease, and the baby is growing normally.The placenta should be examined in a detail in post‐molar pregnancy.
Pregnancy Outcome and Mitral Valve Prolapse
Authors: Chia Y. T. , Yeoh S. C. , Lim M.C.L. , Viegas O. A. , Ratnam S. S. 
Published: August 2010

AbstractMitral valve prolapse (MVP) comprises a large proportion of obstetric cardiac problems and has a general prevalence of 4%. We examined the obstetric outcome of patients with MVP delivered between 1988—1991 at the National University Hospital, Singapore. During this interval, deliveries totalled 16,755 of which 85 (0.51%) had maternal cardiac disease. Of these, 28 (32.9%) had echocardiographic evidence of non‐myxomatous MVP. Ten patients (37.5%) had demonstrable mitral regurgitation and 4 (14.3%) had benign ventricular ectopics.All patients remained well throughout pregnancy. Gestation at delivery and use of analgesia did not differ significantly from non‐cardiac patients. However, the labour induction rate was twice the department average at 17.9%. Twenty‐four (85.7%) patients achieved vaginal delivery and 4 (14.3%) patients were delivered abdominally. All babies were liveborn. Eight patients (28.6%) did not receive antibiotic prophylaxis during labour and postpartum period and remained afebrile. The role of antibiotics in this category of patients is discussed. Patients with MVP without myxomatous valve changes may expect excellent pregnancy outcome.
A Quality Study of a Computerized Medical Birth Registry
Authors: Lu Jen‐Her , Hung Jeng‐Hsiu , Lin Fu‐Mei , Shen Wen‐Yung , Chen Shu‐Jen , Hwang Betau , Wu Shiow‐Ing , Chao Yuh‐Mei Yu 
Published: August 2010

AbstractProcessed by a computerized medical birth registry system, the birth records of 20,103 deliveries, from February 1992 to February 1993, were digitized with medium registry. From January 1, to February 28, 1993, the original records (n = 2,840 cases) of all 10 collaborative hospitals were requested for assessment of the data quality. Thirty‐six items were scored, data of poor quality was found in 8 items; acceptable quality in 4 items; and good quality in 28 items. The feasibility of data transfer by floppy disc and per modem was evaluated. This registry system had shortened data processing time effectively and improved mutual feedback between data center and delivery units. Errors resulting from technical faults originating in preparation of the data for computerizing at hospital level could be effectively reduced. The validity of diagnosis remained as the major source of errors.
Autoimmune Premature Ovarian Failure
Authors: Kim Jung Gu , Moon Shin Yong , Chang Yoon Seok , Lee Jin Yong 
Published: August 2010

AbstractPremature ovarian failure (POF) may be caused by a variety of factors that result in the depletion of responsive ovarian follicles. There is a increasing body of evidence that suggests an autoimmune etiology in some POF patients. Data in support of an autoimmune etiology include: (1) lymphocytic and plasma cell infiltration of the ovary and alteration of T cell subsets; (2) circulating autoantibodies to ovarian antigens; (3) association with other “autoimmune” disorders; (4) recovery of ovarian function after regression of autoimmune status. The mechanism for ovarian autoimmunity is unknown. Genetic or environmental factor might be involved in the stimuli inducing immune response. The possibility that major histocompatibility complex antigen and cytokines are implicated in human autoimmune POF has been proposed. The relative contribution of cell‐mediated immunity and antibody‐mediated immunity remains obscure in animal models and in POF patients. Currently, in vitro fertilization and/or gamete intrafallopian transfer with donated oocytes are the best therapeutic options to achieve pregnancy although ovulation induction and immunosuppressive treatment might be used in approved experimental protocols. A newly developed double bridged enzyme linked immunosorbent assay (ELISA) might be useful in screening POF patients to identify those for whom temporary treatments may improve fertility.
Female Aging and Superovulation Induction for IVF
Authors: Kim Sun‐Haeng 
Published: August 2010

AbstractThe success of in vitro fertilization (IVF) has been reported to be adversely affected by increasing women's age. The main reason being that older women more frequently show a poorer response to stimulation. Information about such variability in ovarian responsiveness to stimulation is important for assessing the chances for successful pregnancy in older women undergoing assisted reproduction, because those with limited ovarian reserve should be counseled to consider other therapeutic options without delay.I present results demonstrating the ovarian response to gonadotropin stimulation and the success rate in 746 IVF cycles. A brief overview on current methods of evaluating ovarian reserve as a means to identify the poor responder, and a discussion on the efficacy of several stimulation regimens for old women with limited ovarian reserve is also provided.
Zona Manipulation in an Assisted Reproductive Technologies (ART) Programme
Authors: Odawara Yasushi , Matsumoto Kazunori , Shinozuka Shoichi , Kusuhara Koji , Terashima Yoshiteru 
Published: August 2010

AbstractsWe investigated whether the aged oocytes maintain the ability to fuse with spermatozoa when the oocyte investment is removed. In the first study, 87 two‐days‐old oocytes provided from IVF‐ET programme were treated with pronase to dissolve the zona pellucida. The oocytes were then inseminated with 100, 10 or 1 per μl sperm and the incidence of monospermic and polyspermic fertilization was determined. In the second study 100 one‐day‐old unfertilized oocytes obtained from 18 IVF patients with “zero fertilization” at initial insemination were treated in the same way to either remove or thinning of the zona pelucida. They were then re‐inseminated with 10 motile sperm per μl of the husband. The incidence of monospermic and polyspermic fertilization were 0.0% (0/13) and 61.6% (8/14), respectively, with a sperm count of 100/μl, 7.3% (3/41) and 31.6% (13/41) with 10/μl, and 14.2% and 11.9% (5/33) with 1/μl. The incidence of monospermic and polyspermic fertilization with reinsemination of one day old oocytes were 12.5% (3/24) and 25.0% (6/24) after zona removal and were 18.3% (9/49) and 10.2% (5/49) after zona thinning. The incidence of fertilization by zona removal was significantly higher than the results of conventional reinsemination (p < 0.001). It appeared that human aged oocytes maintain the ability to fuse spermatozoa after even two days. A higher rate of monospermic fertilization was obtained by carefully controlling the number of spermatozoa for insemination. We concluded that zona manipulation might improve fertilization in vitro in case of severe male factor infertility.
Clinical Trial of Daily Low‐Dose Oral Etoposide for Patients with Residual or Recurrent Cancer of the Ovary or Uterus
Authors: Yasumizu Takehiko , Kato Junzo 
Published: August 2010

AbstractObjective: To determine the efficacy of long‐term therapy of oral etoposide in patients with residual or recurrent gynecologic malignancies.Methods: Twenty‐five Japanese patients with resistant or recurrent carcinoma of the uterus or ovary were treated with oral etoposide at a dose of 25 mg/day/body for 21 consecutive days, and cycles were repeated every 4 weeks. The residual or recurrent lesion could be objectively evaluated in all patients by measuring it directly.Results: The response rate after 6 cycles of therapy was 40% for the group of all patients, and 42.8%, 28.6%, and 50% for those with ovarian carcinoma, cervical carcinoma, and endometrial carcinoma, respectively. Side effects of etoposide treatment included gastrointestinal discomfort in 14 patients and leukopenia of grade 3 or higher in 2 patients. However, these side effects were mild, and all patients could continue treatment.Conclusion: These findings indicate that long‐term, low‐dose oral etoposide was effective for and well‐tolerated by patients with refractory or recurrent carcinoma of the ovary or uterus.
Affect on Neonatal Thyroid Function of Povidone‐Iodine Used on Mothers during Perinatal Period
Authors: Koga Yasutsugu , Sano Hitomi , Kikukawa Yoshiichi , Ishigouoka Tetsuro , Kawamura Mitsuhiro 
Published: August 2010

AbstractObjective: Our objective was to evaluate the affect on the neonatal thyroid function of povidone‐iodine (PVP‐I) used on mothers during the perinatal period.Methods: Eighty consecutive‐term pregnant women were randomly separated into 4 groups. Either PVP‐I or benzethonium chloride (BC) was used to disinfect both maternal skin during labor and vaginal lacerations after delivery in Group I and IV; and PVP‐I or BC was supplied to either skin or lacerations in Groups II and III. On day 5, we measured the iodide concentrations in breast milk and random urine of neonates, and the levels of neonatal thyroid‐stimulating hormone (TSH) and free thyroxine.Results: The TSH levels in Group I and the breast‐milk iodide concentrations in Groups I and II were significantly higher than those in Group IV (p < 0.05). Dietary iodide intake from breast milk correlated significantly with urinary iodide concentrations (r = 0.52, p < 0.001). In our clinic, the recall rate at the time of screening for congenital hypothyroidism was significantly decreased by discontinuing the use of PVP‐I (4.47% vs 0.74%, p < 0.001).Conclusions: These findings suggest that the use of PVP‐I on mothers is associated with transient neonatal hyperthyrotropinemia, in which breast milk might play an important role. Therefore, we recommend that the use of PVP‐I be avoided during labor.
Immunohistochemical Detection of p53 Overexpression in Formalin‐Fixed, Paraffin‐Embedded Sections of Endometrial Carcinoma
Authors: Iwai Kyouko , Hachisuga Toru , Iwasaka Tsuyoshi , Sugimori Hajime 
Published: August 2010

AbstractObjective: In the part, immunohistochemical detection of p53 has been possible only in the case of fresh‐frozen tissues. However using CM1 and an enhanced method based on microwave heating and protease digestion enabled the immunohistochemical detection of p53 overexpression in formalin‐fixed, paraffin‐embedded sections of endometrial carcinoma, although very few positive stainings were obtained without such an enhanced treatment. To evaluate the enhancement method, a comparative study was performed on frozen materials and paraffin‐enbedded samples.Methods: Fifty‐three frozen materials, including normal endometrial glands, endometrial hyperplasias and carcinomas, and paraffin‐embedded samples from the same patients were used in this study. PAb1801 (mouse monoclonal antibody) was used to analyse p53 overexpression in the frozen sections, while CM1 (rabbit polyclonal anti‐p53 antibody) was used for the paraffin sections.Results: PAb1801 and CM1 staining on normal endometriums and endometrial lesions showed a significant degree of concordance between frozen and paraffin‐embedded materials.Conclusion: Enhanced immunodetection of p53 in paraffin‐embedded tissues will provide a useful alternative to the usual fresh‐tissue assay.
Allelic Deletion Mapping of Putative Tumor Suppressor Genes on 17q in Sporadic Ovarian Cancer
Authors: Chen Kuang‐Chao , Hsieh T'sang‐T'ang , Schwartz Peter E. , Yang‐Feng Teresa L. 
Published: August 2010

AbstractObjectives: 1) To study whether the same or different chromosome 17q genes may be involved in the oncogenesis of familial and sporadic ovarian malignancies. 2) To localize the candidate gene in the sporadic ovarian cancers.Methods (Study design): Using DNA extracted from ovarian tumors and corresponding peripheral leukocyte, we examined the status of loss of heterozygosity (LOH) at 12 loci spanning chromosome 17q12–q25 by Southern hybridization and polymerase chain reaction.Results: Comparison of the extent of LOH among 25 epithelial ovarian tumors showing allele loss at one or more loci on 17q, the smallest overlapping region of allelic deletion is between D17S579 and GIP, with a genetic distance of approximate 2cM.Conclusions: From our allelic deletion analysis of chromosome 17q loci, it indicates that there are more than one ovarian cancer candidate genes on chromosome 17q.
Production of Complete Heart Block and Utero Cardiac Pacing in Fetal Lambs
Authors: Murotsuki Jun , Okamura Kunihiro , Watanabe Takanori , Kimura Yoshitaka , Yajima Akira 
Published: August 2010

AbstractWe produced a complete heart block in 5 fetal lambs at 120 to 135 days of gestation by injecting 10% formaldehyde into the His bundle. We obtained acute experimental data in 5 fetuses and chronic experimental data in 2 fetuses. Immediately after production of the complete heart block, cardiac output was acutely reduced to 43 ± 9% when compared with the cardiac output at sinus rhythm. It was possible to restore the cardiac output to 80 ± 7% of the preoperative levels by atrioventricular pacing at the same rate as had been present before the heart block was produced. When the heart rate decreased below 100 beats per minute, further increase of stroke volume did not occur, and output was markedly diminished. This model allows us to study the pathophysiological response of a complete heart block, and offers basic information useful for understanding fetal cardiac functioning.
Intravenous Leiomyomatosis: Three Case‐Reports
Authors: Ogino Masahiro , Urushibata Hironobu , Takada Hiroyuki , Okinaga Shoichi , Mori Hiroyuki , Tanaka Fumihiko , Imamura Tetsuo 
Published: August 2010

AbstractIn the 3 cases of intravenous leiomyomatosis presented here, the retroperitoneal, pelvic, and vaginal veins were completely removed. Two of the cases were diagnosed by a gynecologist at surgery, and 1 was diagnosed by the pathologist performing a histological examination on excised tissue. These 3 cases were asymptomatic in spite of the intravenous invasive leiomyomatosis.
Pregnancy Following Renal Transplantation: The Experience in Hong Kong
Authors: To William W. K. , Lam Kenneth S. K. , Chan Y. M. 
Published: August 2010

AbstractObjective: To assess the outcome of pregnancies occurring after renal transplantation, and to review the factors conductive to a favourable outcome.Method: A retrospective review of 8 pregnancies occurring after renal transplantation from 1988 to 1992 in a tertiary referral centre in Hong Kong.Result: A very high successful pregnancy rate was achieved with minimal maternal and perinatal morbidity in the cases reviewed.Conclusion: Good prepregnancy counselling and stringent criteria for pregnancy assessment appears to be crucial factors for a favourable pregnancy outcome.
Two Cases of Monozygotic Twins, in Each of Which One Fetus Was Prenatally Diagnosed as Having a Heart Anomaly
Authors: Negishi Hiroaki , Okuyama Kazuhiko , Sagawa Tadashi , Makinoda Satoru , Fujimoto Seiichiro 
Published: August 2010

AbstractIn each of the 2 cases of monozygotic twins reported here, 1 of the fetuses was suspected, as a result of a prenatal ultrasonographic examination, of having congenital heart disease (CHD). One of twins (Case 1) had a hypoplastic left heart (HPLH), coarctation of the aorta (CoA), mitral stenosis (MS), and an atrial septal defect (ASD). Of the other twins (Case 2), 1 fetus had pure pulmonary atresia (PPA) and tricuspid regurgitation (TR). In Case 1, the fetus with CHD had a single umbilical artery, the other had otherwise. In Case 2, the fetus with CHD had a velamentous insertion and an accessory placenta, and the other fetus had a marginal insertion. These findings suggest that environmental factors such as blood flow, blood pressure and so on have a role in the etiology of CHD.
Immunohistochemical Expression of Glutathione S‐Transferase π (GST‐π) and Chemotherapy Response in Malignant Ovarian Tumors
Authors: Hirazono Kenichi , Shinozuka Takao , Kuroshima Yoshio , Itoh Hitoshi , Kawai Kenji 
Published: August 2010

AbstractObjectives:To clarify the relationship between the expression of GST‐π and the therapeutic effects of high‐dose combination chemotherapy with support by autologous bone‐marrow transplantation (ABMT).Methods:Expression of GST‐π in tissue specimen were analyzed by indirect immunoperoxidase methods using anti‐GST‐π polyclonal antibody.Results:(1) Eighteen of 36 cases (50%) tested prior to administration of any chemotherapeutic agents were found to be positive in terms of immunohistochemical expression of GST‐π in the cancer cells. (2) The rate of GST‐π expression was elevated following administration of cisplatin, adriamycin, and cyclophosphamide, which suggests that administration of such anti‐cancer agents is capable of inducing expression of GST‐π in cancer cells. (3) GST‐π negative patients exhibit better survival rates than do GST‐π positive patients (Kaplan Meier method: p < 0.05‐0.001).Conclusions:Analysis of GST‐π obtained at primary surgery can serve as a valid marker in anticipating chemotherapeutic effects and long‐term prognoses.
Pregnancy Outcome of Threatened Abortion with Demonstrable Fetal Cardiac Activity: A Cohort Study
Authors: Tongsong Theera , Srisomboon Jatupol , Wanapirak Chanane , Sirichotiyakul Supatra , Pongsatha Saipin , Polsrisuthikul Thongchai 
Published: August 2010

AbstractPregnancy with visible fetal heart beat complicated by first trimester threatened abortion had significant increased risk of subsequent spontaneous abortion compared with normal pregnancy.Objective: To compare pregnancy outcomes in cases complicated by first trimester threatened abortion with those that were not.Methods: Prospective cohort study of 255 cases of first trimester threatened abortions but with visible heart beat and 265 other normal pregnancies.Results: Spontaneous abortion rates of 5.5% (with relative abortal risk of 2.91) was found for study group, compared to 1.88% for controls (p < 0.05). Preterm delivery was also higher, but was not statistically significant.Conclusions: First trimester bleeding with visible fetal heart beat appears to associate significantly with higher subsequent spontaneous abortion rate than those without.
Breast Cancer Metastatic to Uterine Leiomyoma: A Case Report
Authors: Sugiyama Takashi , Toyoda Nagayasu , Nose Junko , Kihira Norihisa , Ando Yoshiyuki , Ishihara Akinori 
Published: August 2010

AbstractA case is reported of a 51‐year‐old woman who had a hysterectomy and bilateral salpingo‐oophorectomy in the same year, following a radical mastoidectomy for breast cancer with metastases to the axillary lymph nodes. Histological examination showed breast cancer metastatic to uterine leiomyoma. The literature about metastasis of extragenital cancer to a leiomyoma is reviewed, and the possible mechanism involved is discussed.
Prelabour Rupture of Membranes to Delivery Interval Related to the Incidence of Maternal and Neonatal Infection
Authors: Chua S. , Arulkumaran S. , Kumar S. Sailesh , Selamat N. , Ratnam S. S. 
Published: August 2010

AbstractObjective: To assess the infectious morbidity associated with prelabour rupture of membranes (PROM) to delivery interval, and the incidence of maternal and neonatal infection in a population managed by either immediate stimulation or by overnight conservatism.Method: A retrospective study of 117 women admitted with PROM to the labour ward in the National University Hospital, Singapore, in the period between June 1990 and May 1991, and who were managed by immediate stimulation or by stimulation after overnight conservatism. Statistical analysis was performed using Chi‐square and Student's t‐test.Results: More than one third of infants whose mothers had ruptured membranes for > 48 hrs had signs of neonatal infection, compared with an incidence of 8.8% and 8.9%, respectively for those with an interval of < 12 hrs and 12–24 hrs between PROM to delivery. Group B streptococcal infection was a major cause of neonatal infectious morbidity. Clinical evidence of maternal infection occurred in 3 of the 117 women; these patients had an interval between rupture of membranes and delivery of between 24–76 hrs.Conclusions: Prolongation of PROM to delivery interval for > 48 hrs increases the incidence of infection. Conservative policy of management of PROM at term should aim to deliver the babies < 48 hrs after PROM. The difference in maternal and neonatal infection rates were not significant in the group treated with a policy of overnight conservatism compared with the group in whom labour was stimulated immediately on admission.
Xanthogranulomatous Oophoritis: An Unusual Complication of Typhoid
Authors: Singh Usha R. , Revathi G. , Gita R. 
Published: August 2010

AbstractThe association of xanthogranulomatous oophoritis with ovarian endometriosis and typhoid is described in a 25 years unmarried female who underwent laparotomy after one year of enteric fever.
Carcinoma of the Uterine Cervix Presenting as Superior Vena Cava Syndrome: Report of Three Cases and a Review of Literature
Authors: Biswal Biswa M. , Sandhu Manavjit S. , Mohanti Bidhu. K. , Rath Gaura K. 
Published: August 2010

AbstractWe present three cases of superior vena cava syndrome secondary to carcinoma of the uterine cervix which manifested 2 to 7 years after the initial diagnosis and primary therapy. In two of these patients, tissue diagnosis could be obtained. Two patients expired within two months of presentation despite timely radiotherapy, and one case died after six months of diagnosis.