bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between altered systemic inflammatory interleukin‐1β and natural killer cell activity and subsequently agitation in patients with alzheimer disease
Authors: Higuchi M. , Hatta K. , Honma T. , Hitomi Y. H. , Kambayashi Y. , Hibino Y. , Matsuzaki I. , Sasahara S. , Nakamura H. 
Published: September 2009

AbstractObjectiveAlzheimer's disease (AD) is a neurodegenerative disorder that is the most common cause of dementia in the elderly and is frequently accompanied by emotional disorder, including agitation. Although evidence of neuroendocrine immune and inflammatory functions during emotional changes has been accumulated, the pathogenic mechanisms in the development of agitation accompanied by AD remain to be elucidated.MethodsTo clarify the involvement of neuroendocrine and immune and inflammatory systems in agitation in AD, we examined agitation levels, circadian rhythms of behavior, cortisol, interleukin‐1β (IL‐1β), and natural killer cell activity (NKCA) in controls without dementia and 16 AD patients who were recognized to be easily agitated in their nursing homes. These behavioral and blood indicators were assessed according to the progress of the stage of agitation in 16 AD patients (stable, pre‐agitation, and agitation stages).ResultsElevations in night behavior and blood cortisol, IL‐1β and an reduced blood NKCA level in the evening were observed not only in the agitation stage, but also when stable in AD patients as compared to the control. Increased IL‐1βand decreased NKCA occurred in both the morning and evening in pre‐agitation and agitation stages in AD.ConclusionsThe increased IL‐1βand decreased NKCA with the progress of agitation in AD suggest that inflammation produces agitation and aggravates AD. Copyright © 2009 John Wiley & Sons, Ltd.
Tumor‐reactive CD8+ T‐cell responses after vaccination with NY‐ESO‐1 peptide, CpG 7909 and Montanide® ISA‐51: association with survival
Authors: Karbach Julia , Gnjatic Sacha , Bender Armin , Neumann Antje , Weidmann Eckhart , Yuan Jianda , Ferrara Cathy A. , Hoffmann Eric , Old Lloyd J. , Altorki Nasser K. , Jäger Elke 
Published: September 2009

AbstractPeptide‐based vaccines have led to the induction of antigen‐specific CD8+ T‐cell responses in patients with NY‐ESO‐1 positive cancers. However, vaccine‐induced T‐cell responses did not generally correlate with improved survival. Therefore, we tested whether a synthetic CpG 7909 ODN (deoxycytidyl‐deoxyguanosin oligodeoxy‐nucleotides) mixed with NY‐ESO‐1 peptide p157‐165 and incomplete Freund's adjuvants (Montanide® ISA‐51) led to enhanced NY‐ESO‐1 antigen‐specific CD8+ immune responses in patients with NY‐ESO‐1 or LAGE‐1 expressing tumors. Of 14 HLA‐A2+ patients enrolled in the study, 5 patients withdrew prematurely because of progressive disease and 9 patients completed 1 cycle of immunization. Nine of 14 patients developed measurable and sustained antigen‐specific CD8+ T‐cell responses: Four had detectable CD8+ T‐cells against NY‐ESO‐1 after only 2 vaccinations, whereas 5 patients showed a late‐onset but durable induction of NY‐ESO‐1 p157‐165 specific T‐cell response during continued vaccination after 4 months. In 6 patients, vaccine‐induced antigen‐specific T‐cells became detectable ex vivo and reached frequencies of up to 0.16 % of all circulating CD8+ T‐cells. Postvaccine T‐cell clones were shown to recognize and lyse NY‐ESO‐1 expressing tumor cell lines in vitro. In 6 of 9 patients developing NY‐ESO‐1‐specific immune responses, a favorable clinical outcome with overall survival times of 43+, 42+, 42+, 39+, 36+ and 27+ months, respectively, was observed.
Identification of HLA‐A2‐ and A24‐restricted T‐cell epitopes derived from SOX6 expressed in glioma stem cells for immunotherapy
Authors: Ueda Ryo , Ohkusu‐Tsukada Kozo , Fusaki Noemi , Soeda Akio , Kawase Takeshi , Kawakami Yutaka , Toda Masahiro 
Published: September 2009

AbstractMalignant gliomas are the most aggressive human primary brain tumors and are currently incurable. Immunotherapies have the potential to target glioma and glioma stem cells (GSCs) that are resistant to conventional therapies. We previously identified SOX6 as a human glioma antigen and demonstrated that vaccination with SOX6 DNA induced cytotoxic T lymphocytes (CTLs) specific for glioma, thereby exerting therapeutic antitumor responses in glioma‐bearing mice. In this study, we attempted to identify SOX6‐derived peptides as specific targets for effective and safe T‐cell‐mediated immunotherapy targeting SOX6‐positive glioma and GSCs. In vitro stimulation with human leukocyte antigen (HLA)‐A*2402 (A24)‐restricted peptides, RFENLGPQL (SOX6504) and PYYEEQARL (SOX6628) or the HLA‐A*0201 (A2)‐restricted peptide, ALFGDQDTV (SOX6447) was capable of inducing SOX6 peptide‐specific CTLs in peripheral blood mononuclear cells derived from healthy donors and glioma patients. These CTLs were able to lyse a majority of glioma cell lines and a GSC line derived from human glioblastoma in an HLA Class I‐restricted and an antigen‐dependent manner. Furthermore, peptide vaccines of SOX6628, which was conserved in the murine SOX6 protein and expected to bind to major histocompatibility complex (MHC) H‐2d, induced CTLs specific for SOX6628 in H‐2d mice. Normal autologous cells from mice, in which SOX6‐specific immune responses were generated, were not destroyed. These results suggest that these SOX6 peptides are potnetially immunogenic in HLA‐A24 or ‐A2 positive glioma patients and should be considered as a promising strategy for safe and effective T‐cell‐based immunotherapy of patients with gliomas.
The prognostic role of classical and nonclassical MHC class I expression in endometrial cancer
Authors: Bijen Claudia B.M. , Bantema‐Joppe Enja J. , de Jong Renske A. , Leffers Ninke , Mourits Marian J.E. , Eggink Henk F. , van der Zee Ate G.J. , Hollema Harry , de Bock Geertruida H. , Nijman Hans W. 
Published: September 2009

AbstractThe aim of this study was to investigate classical MHC class I and nonclassical MHC (human leukocyte antigen‐G [HLA‐G]) expression in a large cohort of patients with endometrial cancer, to determine the prognostic value of these cell surface markers and their relation with clinicopathological variables. Tissue microarrays containing epithelial endometrial carcinoma tissue from 554 patients were stained for classical and nonclassical MHC class I using the following monoclonal antibodies: 4H84 (anti‐HLA‐G), β2‐m (anti‐beta‐2‐microglobulin) and HC‐10 (MHC class I antigen heavy chain). Expression data were linked to known clinicopathological characteristics and survival. HLA‐G upregulation and MHC class I downregulation in neoplastic cells was observed in 40% and 48%, respectively. Nonendometrioid tumor type, advanced stage disease (FIGO stage ≥II) and poorly or undifferentiated tumors were associated with MHC class I downregulation. Absence of HLA‐G expression was independently associated with MHC class I downregulation. In univariate analysis, MHC class I downregulation was a predictor of worse disease‐specific survival. Prognostic unfavorable tumor characteristics were correlated with downregulation of MHC class I expression in endometrial cancer cells. Furthermore, downregulated MHC class I has a negative impact on disease‐specific survival, observed in a large cohort of patients with endometrial cancer. As there seems to be a relation between classical and nonclassical MHC class I molecules (HLA‐G), further research is warranted to unravel this regulatory mechanism.
High expression levels of IKKα and IKKβ are necessary for the malignant properties of liver cancer
Authors: Jiang Runqiu , Xia Yongxiang , Li Jun , Deng Lei , Zhao Liang , Shi Jian , Wang Xuehao , Sun Beicheng 
Published: September 2009

AbstractIKK‐NF‐κB signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy. Therefore, in this study, we analyzed the expression of mRNAs encoding components and targets of NF‐κB signaling including IKKα, IKKβ, RANK, RANKL, OPG, CyclinD3, mammary serine protease inhibitor (Maspin), CyclinD1, c‐FLIP, Bcl‐xl, Stat3, Cip1 and Cip2 by real‐time PCR in 40 patients with liver cancer. After statistical analysis, 7 indices including IKKα, IKKβ, RANK, Maspin, c‐FLIP, Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue. When IKKα and IKKβ were downregulated in the hepatocellular carcinoma (HCC) cell lines of MHCC‐97L and MHCC‐97H in vitro, the numbers of BrdU positive cells were decreased in both IKKα and IKKβ knockdown cells. Levels of apoptosis were also investigated in IKKα and IKKβ knockdown cells. The growth of HCC was inhibited in the subcutaneous implantation model, and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model. Downregulation of IKKα and IKKβ in HCC cultured in vitro revealed that increased Maspin, OPG and RANKL expression was associated with metastasis of HCC. These findings were associated with downregulation of Bcl‐XL and c‐FLIP, which may be the reason for increased apoptosis. The therapeutic effect of IKKα and IKKβ downregulation depends on extent of NF‐κB inhibition and the malignant nature of the HCC. We anticipate that IKK‐targeted gene therapy can be used in the treatment of HCC, a cancer that is notoriously resistant to radiation and chemotherapy.
Effects of parental supportiveness on toddlers' emotion regulation over the first three years of life in a low‐income African American sample
Authors: Bocknek Erika London , Brophy‐Herb Holly E. , Banerjee Meeta 
Published: September 2009

AbstractThe purpose of this study was to examine how parental supportiveness and child gender are related to toddlers' emotion regulation over time among low‐income African American mothers and their children (n= 803). Data for the current study were collected as part of the Early Head Start Research and Evaluation Project. Using latent growth curve modeling, results indicated that parental supportiveness predicted toddlers' emotion regulation skills, on average (intercepts), and rates of growth of parental supportiveness predicted the rates of growth in emotion regulation over time (slope), beyond the effects of initial parental risk status, child gender, Early Head Start treatment effects, and infant emotionality. However, parental supportiveness over time did not differentially predict toddler emotion regulation over time for boys as compared to girls. Results suggest that parental supportiveness may represent a subtle form of emotion socialization by providing a context in which toddlers may be better able to utilize their mothers as effective resources in managing emotions. Practitioners should emphasize with the parents the role of parent–child interactions as a context for development. The lack of gender differences suggests that differential parenting towards boys and girls, evident in research with older children, may not yet be present in toddlerhood. Recognizing similarities in parenting across racial groups early on as well as being sensitive to differences that may emerge later will position practitioners to provide support within a culturally sensitive framework.
Respectful relationships: Socialization goals and practices among Mexican mothers
Authors: Zucker Eleanor , Howes Carollee 
Published: September 2009

AbstractThis article examines the socialization goals, representations, and practices in toddler‐ and preschool‐age children and their Mexican immigrant or U.S.‐born, Mexican‐heritage mothers. Eighty‐eight mothers and children (49% girls) participated in this research. All mothers were visited in their homes to be observed and interviewed when the children were 8, 14, 24, and 36 months old. The study used naturalistic observations of children's behavior and participation in everyday routines and their mothers' socialization practices. Prekindergarten teachers reported on the children's school social skills. It was expected that differences in mothers' participation in four distinct cultural communities would be associated with variations in their socialization goals and practices. The mothers articulated socialization goals that were reflective of positive social relationships. Compliance episodes were less frequent than participation in everyday routines. The mothers' participation in different cultural communities was associated with different practices in routines, but not with goals or compliance practices. Toddler and preschool observations of children and mothers were associated with teachers' ratings of children's prekindergarten social skills.
Intelligence‐led policing at the Amsterdam‐Amstelland Police Department: operationalized business intelligence with an enterprise ambition
Authors: Viaene Stijn , De Hertogh Steven , Lutin Luc , Maandag Annemarie , Den Hengst Stephan , Doeleman Reinder 
Published: September 2009

AbstractThis article elaborates on the setup for intelligence‐led policing in support of ensuring public safety as it presented itself in the Spring of 2007 at the Amsterdam‐Amstelland Police Department in the Netherlands. The picture that is painted is the outcome of a qualitative research effort involving semi‐structured interviews triangulated with other internal data sources. The main goal of the article is to establish how an organization can leverage its operationalized business intelligence ambition by connecting it into an ambition for better enterprise management. The case ends in showcasing two popular operational business intelligence tools instrumental to capacity management. Copyright © 2009 John Wiley & Sons, Ltd.
IL‐17 induces osteoclastogenesis from human monocytes alone in the absence of osteoblasts, which is potently inhibited by anti‐TNF‐α antibody: A novel mechanism of osteoclastogenesis by IL‐17
Authors: Yago Toru , Nanke Yuki , Ichikawa Naomi , Kobashigawa Tsuyoshi , Mogi Makio , Kamatani Naoyuki , Kotake Shigeru 
Published: September 2009

AbstractIL‐17 is a proinflammatory cytokine crucial for osteoclastic bone resorption in the presence of osteoblasts or synoviocytes in rheumatoid arthritis. However, the role of IL‐17 in osteoclastogenesis from human monocytes alone remains unclear. Here, we investigated the role of IL‐17 in osteoclastogenesis from human monocytes alone and the direct effect of infliximab on the osteoclastogenesis induced by IL‐17. Human peripheral blood mononuclear cells (PBMC) were cultured for 3 days with M‐CSF. After non‐adherent cells were removed, IL‐17 was added with either infliximab or osteoprotegerin (OPG). Seven days later, adherent cells were stained for vitronectin receptor. On the other hand, CD11b‐positive monocytes purified from PBMC were also cultured and stained as described above. CD11b‐positive cells were cultured with TNF‐α and receptor activator of NF‐κB ligand (RANKL). In the cultures of both adherent cells and CD11b‐positive cells, IL‐17 dose‐dependently induced osteoclastogenesis in the absence of soluble‐RANKL. OPG or infliximab inhibited IL‐17‐induced osteoclastogenesis. Interestingly, in the culture of CD11b‐positive cells, the osteoclastogenesis was more potently inhibited by infliximab than by OPG. TNF‐α and RANKL synergistically induced osteoclastogenesis. The present study clearly demonstrated the novel mechanism by which IL‐17 directly induces osteoclastogenesis from human monocytes alone. In addition, infliximab potently inhibits the osteoclastogenesis directly induced by IL‐17. J. Cell. Biochem. 108: 947–955, 2009. © 2009 Wiley‐Liss, Inc.
5,5‐diaryl and 5‐alkyl‐3‐phenyl‐4‐imidazolidones: A novel synthesis
Authors: Khurana Jitender M. , Agrawal Arpita , Bansal Geeti 
Published: September 2009

Abstract
magnified imageSynthesis of 5,5‐diaryl and 5‐alkyl‐3‐phenyl‐4‐imidazolidones has been reported by reductive desulfurization of 5,5‐diaryl and 5‐alkyl‐3‐phenyl‐2‐thiohydantoins with nickel boride. J. Heterocyclic Chem., (2009).
Synthesis of novel naphth[1,2‐f][1,4]oxazepine‐3,4‐dione heterocycles
Authors: Ghandi Mehdi , Olyaei Abolfazl , Raoufmoghaddam Saeed 
Published: September 2009

Abstract
magnified imageA number of N‐heteroaryl aminonaphthols (Betti bases) were prepared from the reaction of 2‐naphthol, 3‐aminopyridine, and aromatic aldehydes. Subsequent condensation of the prepared Betti bases with oxalyl chloride afforded the novel naphth[1,2‐f][1,4]oxazepine‐3,4‐dione heterocycles in moderate to high yields. J. Heterocyclic Chem., (2009).
Synthesis of functionalized 1,2,3‐triazole derivatives of 2‐indolones from Morita‐Baylis‐Hillman adducts of isatin via “click chemistry”
Authors: Shanmugam Ponnusamy , Damodiran Mumusamy , Selvakumar Kodirajan , Perumal Paramasivan T. 
Published: September 2009

Abstract
magnified imageA short and efficient regioselective synthesis of a number of 1,4‐disubstituted‐1,2,3‐triazole derivatives of oxindoles from N‐terminal alkyne and alkynyl ether derivatives of Morita‐Baylis‐Hillman (MBH) adducts of isatin with in situ generated alkyl azide and copper(I) iodide as a catalyst in 1:1 mixture of t‐BuOH:water as a solvent system has been achieved. The synthetic procedure tolerates most of the functional groups present in the MBH adducts and circumvents the problems associated with the isolation of potentially toxic and explosive organic azides. J. Heterocyclic Chem., (2009).
Synthesis and potent antifungal activity against Candida species of some novel 1H‐benzimidazoles
Authors: Göker Hakan , Alp Mehmet , Ateş‐Alagöz Zeynep , Yıldız Sulhiye 
Published: September 2009

Abstract
magnified imageA series of 47 novel N1‐alkylated‐2‐aryl‐5(6)‐substituted‐1H‐benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C‐2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25–3.12 μg/mL. Indole analogues 108‐110 have no inhibitory activity. J. Heterocyclic Chem., (2009).
An efficient one‐pot synthesis of naphthoxazinones by a three‐component coupling of naphthol, aldehydes, and urea catalyzed by zinc triflate
Authors: Hajra Alakananda , Kundu Dhiman , Majee Adinath 
Published: September 2009

Abstract
magnified imageA simple and efficient method has been developed for the synthesis of 4‐aryl‐3,4‐dihydronaphtho[2,1‐e] [1,3]oxazin‐2‐one and 1‐aryl‐1,2‐dihydronaphtho[1,2‐e][1,3]oxazin‐3‐one derivatives through a one‐pot three‐component coupling of α or β‐naphthol, aromatic aldehydes and urea using a catalytic amount of zinc triflate in refluxing acetonitrile. J. Heterocyclic Chem., (2009).
Using SPC to analyze quality indicators in a healthcare organization
Authors: Kaminsky Frank C. , Maleyeff John , Providence Sherry , Purinton Esther , Waryasz Mary 
Published: September 2009

AbstractA tool of statistical process control (SPC) called a P Chart is introduced as a process‐ based approach for analyzing quality indicators in healthcare. The underlying methodology of a P Chart is described using card‐playing examples. A discussion on the implementation of SPC in healthcare follows, along with examples using Maryland Project quality indicators.
Protection against employment claims
Authors: Ericson R. Peter , Pendrak Robert F. 
Published: September 2009

AbstractRisk managers already deal with a great many issues in today's complex, managed‐care driven, healthcare environment. Now they must add expertise in handling ever more complicated employment issues. This article addresses areas risk managers need to both know and understand concerning this area of law, and some steps they can take to minimize loss or provide for insurance protection for any loss.
Placing the cornerstone for healthcare professionals' risk management education: An educational needs assessment
Authors: Seisser Mary A. , Epstein Alice L. 
Published: September 2009

AbstractThe risk manager's performance of an educational needs assessment to assist in determining related training and development elements supports a solid, proactive risk management program designed to motivate healthcare professionals. Environmental scanning, needs assessment tool design and development, tool validation, organizational commitment and ethical considerations are examined. A sample needs assessment tool is provided.
Is the obstetric guideline of 30 minutes from decision to incision for cesarean delivery clinically significant?
Authors: Lavery J. Patrick , Janssen Jane , Hutchinson Linda 
Published: September 2009

AbstractA Cesarean delivery may be critical to the health and wellbeing of a newborn. The time required to extract an infant from a hostile in utero environment is a frequent issue in medical negligence cases. The American College of Obstetricians and Gynecologists and the American Academy of Pediatrics suggest a time guideline of 30 minutes from decision for Cesarean delivery to the beginning (incision) of the procedure. This time frame is based on survey data from hospitals throughout the United States and is not based on clinical outcomes or the pathophysiology of obstetric events. This review focuses on specific Cesarean indications as noted by the specialty groups and analyzes them from an outcome point of view. The authors conclude that specific high‐risk factors do indeed warrant delivery in as expedient a fashion as possible; however, compliance with the 30‐minute guideline does not necessarily lead to a difference in outcome as far as the neonate is concerned.
The early diagnosis project: A collaborative approach to risk management
Authors: Bartlett Edward E. , Holman K. Inge , Bobetic Karen , Douglass Margaret , Johnson Lee , MacHnowski Gary , Rehmar Michael I. 
Published: September 2009

AbstractDiagnostic errors account for one‐fifth of lawsuits against hospitals and physicians. Virtually all medical specialties are at risk for these law suits. To this point, risk managers have done little to assist physicians to reduce their risk of failure‐to‐diagnose (FTD) lawsuits. This article describes a collaborative effort to reduce FTD law suits in the primary care setting.
Risk investigations involving genetic identification
Authors: Wenk Robert E. 
Published: September 2009

AbstractRisk managers should consider misidentifications as causes of otherwise unexplained diagnostic and process errors. Genetic tests are powerful tools that can resolve problem cases and indicate ways to improve patient‐sample identification. Genetic typing, especially for DNA markers, has provided evidence of patient or sample identity in 21 of 22 hospital and laboratory cases of accidental or intentional patient misidentification, specimen mislabeling, and sample contamination. Identity is established with very high probability if infrequent genetic markers are observed in both unknown and reference specimens. The odds of a match of markers express both the infrequency of finding the match by chance (in specified populations) and the adequacy of testing. Genetic tests establish nonidentity with virtual certainty.
Whistleblowers and nuclear medicine
Authors: Rysavy Charles F. , Donald J. Wylie 
Published: September 2009

AbstractHealthcare facilities that practice nuclear medicine are subject to federal “whistleblower” protection laws when an employee reports a potentially unsafe radiological condition. This article addresses enforcement of the applicable sections of the Atomic Energy Act and the Nuclear Regulatory Commissions regulations in order to help such facilities avoid running afoul of those laws, which can result in fines, generate civil lawsuits by the claimant, and significantly disrupt the operation of a healthcare facility.
Now that we own it, What do i do with it? identifying risk management issues in acquired physician practices
Authors: Mouse‐Young Donna 
Published: September 2009

AbstractHealthcare risk managers now have responsibility for identifying and managing the unique exposures of the physicians office practice. This article focuses on exposures related to general communication systems and functions including telephone routing systems, voice mail, faxing, e‐mail, and more, which can be found in the clinic environment.