bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of recorded medication use in the Medical Birth Registry of Norway with prescribed medicines registered in the Norwegian Prescription Database
Authors: Espnes Marte Gravseth , Bjørge Tone , Engeland Anders 
Published: December 2010

AbstractPurposeMaternal medication use during pregnancy is explored extensively, as it may cause birth defects. This study aimed to evaluate the validity of recorded medication use in the Medical Birth Registry of Norway (MBRN).MethodsThis study was based on the nationwide population‐based registries, the MBRN and the Norwegian Prescription Database (NorPD). These registries were linked using a unique 11‐digit identification number. The sensitivity, specificity and positive predictive value (PPV) of recorded medication use in MBRN were computed using data from NorPD as the reference.ResultsAmong the 163,678 pregnancies included in our study, the sensitivity for total drug use during pregnancy was calculated to be 32% and PPV was 82%. When we looked at the use of medication during the whole pregnancy, the sensitivities of drug registration for the main groups in the Anatomical Therapeutic Chemical (ATC)‐classification varied from 50% (ATC group H) to 2% (ATC group S).ConclusionThe medication use recorded in MBRN is poor compared with prescribed medicines registered in NorPD. There was a substantial difference between the different ATC codes regarding the sensitivity of MBRN in the registration of medication use during pregnancy. Copyright © 2010 John Wiley & Sons, Ltd.
Harte Nuss für Theoretiker. Hundert Jahre Supraleitung
Authors: Huebener Rudolf P. 
Published: December 2010

Abstract1911 entdeckte der niederländische Physiker Heike Kamerlingh Onnes das Phänomen der Supraleitung. Er hatte auch früh die Vision, diese technisch einzusetzen. In den 1930er Jahren fanden Walther Meißner und Robert Ochsenfeld mit dem nach ihnen benannten Effekt die zweite grundlegende Eigenschaft der Supraleitung. Eine Theorie zur klassischen Supraleitung gelang John Bardeen, Leon Cooper und Robert Schrieffer im Jahr 1957. Zuvor hatte Alexei Abrikossow mit den Flusslinien eine wichtige Eigenschaft von Typ‐II‐Supraleitern entdeckt. Diese bahnten den Weg zu den ersten technischen Anwendungen. 1986 entdeckten dann Georg Bednorz und Alex Müller die Hochtemperatur‐Supraleitung. Inzwischen sind zu diesen Kupraten weitere neue Hochtemperatur‐Supraleiter hinzu gekommen.
Separated by a common translation? How the british and the dutch communicate
Authors: Rottier Bart , Ripmeester Nannette , Bush Andrew 
Published: December 2010

AbstractThe British and Dutch share a long naval‐, war‐ and medical history, in good times as well as bad. Their language has a common Germanic origin, but the English people may use special ways to express values or opinions, from which the sometimes paradoxical meaning is not always clear to the other party. Particularly with the Dutch, renowned for their directness, this may cause confusion. We provide a comprehensive set of expressions, each with paired interpretations, to foster Anglo–Dutch cooperation. Pediatr Pulmonol. 2011; 46:409–411. © 2010 Wiley‐Liss, Inc.
Pulmonary surfactant in respiratory syncytial virus bronchiolitis: The role in pathogenesis and clinical implications
Authors: Barreira Eliane Roseli , Precioso Alexander Roberto , Bousso Albert 
Published: December 2010

AbstractRespiratory syncytial virus (RSV) bronchiolitis is the leading cause of lower respiratory tract infection, and the most frequent reason for hospitalization among infants throughout the world. In addition to the acute consequences of the disease, RSV bronchiolitis in early childhood is related to further development of recurrent wheezing and asthma. Despite the medical and economic burden of the disease, therapeutic options are limited to supportive measures, and mechanical ventilation in severe cases. Growing evidence suggests an important role of changes in pulmonary surfactant content and composition in the pathogenesis of severe RSV bronchiolitis. Besides the well‐known importance of pulmonary surfactant in maintenance of pulmonary homeostasis and lung mechanics, the surfactant proteins SP‐A and SP‐D are essential components of the pulmonary innate immune system. Deficiencies of such proteins, which develop in severe RSV bronchiolitis, may be related to impairment in viral clearance, and exacerbated inflammatory response. A comprehensive understanding of the role of the pulmonary surfactant in the pathogenesis of the disease may help the development of new treatment strategies. We conducted a review of the literature to analyze the evidences of pulmonary surfactant changes in the pathogenesis of severe RSV bronchiolitis, its relation to the inflammatory and immune response, and the possible role of pulmonary surfactant replacement in the treatment of the disease. Pediatr. Pulmonol. 2011; 46:415–420. © 2010 Wiley‐Liss, Inc.
Pulmonary sequestration of the left upper lobe associated with a bronchogenic cyst: Case report of an exceptional association
Authors: Barbut J. , Fernandez C. , Blanc F. , Dubus J.C. , Guys J.M. , de Lagausie P. 
Published: December 2010

AbstractIntralobar pulmonary sequestration (ILPS) and bronchogenic cyst are rare congenital diseases. We present the first case of the association between an ILPS located in the upper lobe and a bronchogenic cyst. This association has been discovered antenatally in a girl. The cystic lesion has been shown by a fetal MRI and confirmed by a CT scan at 3 weeks of life. She underwent a left upper lobectomy by thoracoscopy at the age of 5 months. Postoperative course was uneventfull. This case confirms the congenital origin of pulmonary sequestration and shows the interest of an early surgery. Pediatr. Pulmonol. 2011; 46:509–511. © 2010 Wiley‐Liss, Inc.
Reduced‐order design of high‐order sliding mode control system
Authors: Pan Yaodong , Kumar Krishna Dev , Liu Guangjun 
Published: December 2010

AbstractTo design an rth (r>2) order sliding mode control system, a sliding variable and its derivatives of up to (r − 1) are in general required for the control implementation. This paper proposes a reduced‐order design algorithm using only the sliding variable and its derivatives of up to (r − 2) as the extension of the second‐order asymptotic sliding mode control. For a linear time‐invariant continuous‐time system with disturbances, it is found that a high‐order sliding mode can be reached locally and asymptotically by a reduced‐order sliding mode control law if the sum of the system poles is less than the sum of the system zeros. The robust stability of the reduced‐order high‐order sliding mode control system, including the convergence to the high‐order sliding mode and the convergence to the origin is proved by two Lyapunov functions. Simulation results show the effectiveness of the proposed control algorithm. Copyright © 2010 John Wiley & Sons, Ltd.
The impact of science content and professional learning communities on science teaching efficacy and standards‐based instruction
Authors: Lakshmanan Aruna , Heath Barbara P. , Perlmutter Aaron , Elder Michael 
Published: December 2010

AbstractThis study examines the impact of standards‐based professional development on teacher efficacy and instructional practice of elementary and middle school science teachers. Professional development activities were conducted over a period of 3 years and included content courses as well as teacher involvement in professional learning communities. Teacher efficacy was assessed at five time points using the Science Teacher Efficacy Beliefs Instrument (STEBI), and instructional practice was evaluated at four time points with classroom observations using the Reformed Teaching Observation Protocol (RTOP). Results indicate that there was significant growth in teacher self‐efficacy but not in outcome expectancy. There was also significant growth in the extent to which teachers implemented inquiry‐based instruction in the classroom. Additionally, a positive correlation was observed between changes in self‐efficacy and changes in the use of inquiry‐based instructional practice. These results are discussed in terms of a model of teacher learning wherein changes in teacher beliefs and changes in classroom practice mutually influence each other, and also in terms of the impact of collaboration on teacher efficacy and practice. © 2010 Wiley Periodicals, Inc., Inc. J Res Sci Teach 48: 534–551, 2011
Science student role: Evidence of social structural norms specific to school science
Authors: Shanahan Marie‐Claire , Nieswandt Martina 
Published: December 2010

AbstractSociocultural studies of science education have consistently recognized the dialectic nature of students' agency to create and author positions for themselves and the structural constraints that may influence them. This mixed‐methods study explores one particular aspect of these potential constraints: the possibility of a social structure specific to school science, using the concept of a science student role as an indicator. The first phase of the study was qualitative and exploratory, using open‐ended questionnaires and interviews to understand students' views of the expectations placed on them as science students (n = 95). The second phase was quantitative (using items developed from the qualitative analysis), with both exploratory and confirmatory elements (n = 157). Results suggest clear and explicit role understandings among these students, characterized by references to expectations of intelligence, experimental skill, scientific mindedness, and appropriate classroom behavior. The consistency of these expectations across genders, science teachers and schools provides evidence that there is an element of social structure specific to school science that needs to be considered in studies of student agency and identity. © 2010 Wiley Periodicals, Inc., Inc. J Res Sci Teach 48: 367–395, 2011
Supply chain collaboration: Impact on collaborative advantage and firm performance
Authors: Cao Mei , Zhang Qingyu 
Published: December 2010

AbstractFacing uncertain environments, firms have strived to achieve greater supply chain collaboration to leverage the resources and knowledge of their suppliers and customers. The objective of the study is to uncover the nature of supply chain collaboration and explore its impact on firm performance based on a paradigm of collaborative advantage. Reliable and valid instruments of these constructs were developed through rigorous empirical analysis. Data were collected through a Web survey of U.S. manufacturing firms in various industries. The statistical methods used include confirmatory factor analysis and structural equation modeling (i.e., LISREL). The results indicate that supply chain collaboration improves collaborative advantage and indeed has a bottom‐line influence on firm performance, and collaborative advantage is an intermediate variable that enables supply chain partners to achieve synergies and create superior performance. A further analysis of the moderation effect of firm size reveals that collaborative advantage completely mediates the relationship between supply chain collaboration and firm performance for small firms while it partially mediates the relationship for medium and large firms.
Lead identification and docking studies of metastatic protein human mitogen activated protein kinase kinase4
Authors: Meduru Harika , Pradhan Dibyabhaba , Munikumar Manne , Umamaheswari Amineni 
Published: December 2010

AbstractHuman dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. Upon phosphorylation, MAP2K4 has been shown to activate MAPK8, MAPK9 and MAPK14/p38 but not MAPK1/ERK2 or MAPK3/ERK1. Over expression of MAP2K4 causes carcinogenic effects, such as ovarian cancer, colorectal cancer, prostate cancer and pancreatic cancer. Our present study was carried out to design a potent drug molecule against MAP2K4 to control over expression. As there is no experimentally determined structure for MAP2K4, the homology modeling technique of Modeller9v7 was implemented to generate a MAP2K4 3D model based on the co-crystal structure of MAP2K6 (PDB ID: 3FME) with staurosporine. Twenty such models obtained were accessed through DOPE score, PROCHECK, ProSA and the highly reliable model was further optimized for virtual screening in Maestro v9.0 applying OPLS2001 force field. MAP2K4 specific inhibitors such as staurosporine, genistein and cayanidin were selected and screened against one million entries of the Ligand.Info Meta-Database, to generate an in house library of 1151 analogs. LigPrep was used to generate multiple conformations of the in-house ligands. In an effort to ensure good ADMET properties of the selected ligands Lipinski filter and reactive filter was applied. The strategic computational docking using Glide v5.5 ranked 10 lead molecules with good binding affinity with MAP2K4. Among ten lead molecules Lead ‘1’, Lead ‘2’, Lead ‘3’ had higher binding affinity than the published inhibitors. The scores for Lead ‘1’ -8.75, Lead ‘2’ -8.54, Lead ‘3’ -7.96 and scores for published inhibitors are STAUROSPORINE: -6.55; GENISTEIN: -6.42 and CAYANIDINE: -6.24. So Lead ‘1’ with the lowest docking score (-8.75kcal/mol) is the best ligand for protein functional activity inhibition. Lead ‘1’ directly binds to the MAP2K4 protein by forming strong hydrogen bonds with LYS-131, LEU-180, LYS-231, ASP-229. So we can consider that the lead ‘1’ molecule can act as a potent inhibitor for MAP2K4.
Docking studies to explore novel lead molecules for human Spleen tyrosine kinase involved in chronic lymphocytic leukemia
Authors: Kadaari Naveen , Pradhan Dibyabhaba , Munikumar Manne , Umamaheswari Amineni 
Published: December 2010

AbstractB-cell chronic lymphocytic leukemia (CLL) is the most prevalent B-cell malignancy in adults. Despite advances in treatment, the disease remains incurable, warranting further efforts to identify novel molecular targets and inhibitors. Spleen tyrosine kinase (SYK) plays a pivotal role for B-lymphocyte development and maturation in the B-cell receptor (BCR) signaling pathway and hence represents a potential therapeutic target for CLL. The present study is directed towards finding novel inhibitors of SYK through ligand based virtual screening. The co-crystal structure of SYK was investigated to locate active site residues (Glu-449, Ala-451 Arg-498, Asn-499, Ser-511, and Asp-512). Five SYK specific published inhibitors (Gleevec, staurosporine, Bay61-3606, R-406 and p5c) were explored against more than one million entries of the Ligand.Info metadatabase to create an in-house library of 1957 structural analogs. Ligand dataset was prepared using LigPrep and filtered based on Lipinski’s rule of five and reactive group constraints. Docking using Computational Glide v5.5 from lesser to higher stringency towards minor steric classes were applied subsequently to the prepared ligand dataset against a grid around the centroid of the SYK active site. Fifteen lead molecules with good binding affinity to SYK were identified and compared with binding affinities and orientations of five published inhibitors. Apigenin (-10.05 Kcal/mol) and Glafenine (-9.72 Kcal/mol) endeavored better binding affinities, hydrogen bonding network and Van der Waal interactions with active site residues compared to published inhibitors. Thus, Apigenin and Glafenine would be valuable for designing a novel inhibitor against CLL, if synthesized and tested in vitro and in vivo.
CompleteMOTIFs: DNA motif discovery platform for transcription factor binding experiments
Authors: Kuttippurathu Lakshmi , Hsing Michael , Liu Yongchao , Schmidt Bertil , Maskell Douglas L. , Lee Kyungjoon , He Aibin , Pu William T. , Kong Sek Won 
Published: December 2010

Abstract
Summary:CompleteMOTIFs (cMOTIFs) is an integrated web tool developed to facilitate systematic discovery of overrepresented transcription factor binding motifs from high-throughput chromatin immunoprecipitation experiments. Comprehensive annotations and Boolean logic operations on multiple peak locations enable users to focus on genomic regions of interest for de novo motif discovery using tools such as MEME, Weeder and ChIPMunk. The pipeline incorporates a scanning tool for known motifs from TRANSFAC and JASPAR databases, and performs an enrichment test using local or precalculated background models that significantly improve the motif scanning result. Furthermore, using the cMOTIFs pipeline, we demonstrated that multiple transcription factors could cooperatively bind to the upstream of important stem cell differentiation regulators.
Availability: http://cmotifs.tchlab.org
Contact: sekwon.kong@childrens.harvard.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
The Hydroxypyruvate-Reducing System in Arabidopsis: Multiple Enzymes for the Same End
Authors: Timm Stefan , Florian Alexandra , Jahnke Kathrin , Nunes-Nesi Adriano , Fernie Alisdair R. , Bauwe Hermann 
Published: December 2010

Abstract
Hydroxypyruvate (HP) is an intermediate of the photorespiratory pathway that originates in the oxygenase activity of the key enzyme of photosynthetic CO2 assimilation, Rubisco. In course of this high-throughput pathway, a peroxisomal transamination reaction converts serine to HP, most of which is subsequently reduced to glycerate by the NADH-dependent peroxisomal enzyme HP reductase (HPR1). In addition, a NADPH-dependent cytosolic HPR2 provides an efficient extraperoxisomal bypass. The combined deletion of these two enzymes, however, does not result in a fully lethal photorespiratory phenotype, indicating even more redundancy in the photorespiratory HP-into-glycerate conversion. Here, we report on a third enzyme, HPR3 (At1g12550), in Arabidopsis (Arabidopsis thaliana), which also reduces HP to glycerate and shows even more activity with glyoxylate, a more upstream intermediate of the photorespiratory cycle. The deletion of HPR3 by T-DNA insertion mutagenesis results in slightly altered leaf concentrations of the photorespiratory intermediates HP, glycerate, and glycine, indicating a disrupted photorespiratory flux, but not in visible alteration of the phenotype. On the other hand, the combined deletion of HPR1, HPR2, and HPR3 causes increased growth retardation, decreased photochemical efficiency, and reduced oxygen-dependent gas exchange in comparison with the hpr1xhpr2 double mutant. Since in silico analysis and proteomic studies from other groups indicate targeting of HPR3 to the chloroplast, this enzyme could provide a compensatory bypass for the reduction of HP and glyoxylate within this compartment.
The natural history of acute hepatitis C: clinical presentation, laboratory findings and treatment outcomes
Authors: Loomba R. , Rivera M. M. , McBurney R. , Park Y. , Haynes‐Williams V. , Rehermann B. , Alter H. J. , Herrine S. K. , Liang T. J. , Hoofnagle J. H. , Heller T. 
Published: December 2010

Aliment Pharmacol Ther 2011; 33: 559–565SummaryBackground  Acute hepatitis C has variable modes of presentation and frequently results in chronic infection. Its optimal management has yet to be defined.Aim  To establish natural history and complications of treatment of acute hepatitis C.Methods  Data from all patients presenting with acute hepatitis C to the National Institutes of Health between 1994 and 2007 were reviewed.Results  Twenty‐five patients were identified. Symptoms were reported by 80% and jaundice by 40%. Aminotransferase levels and hepatitis C virus (HCV) RNA levels fluctuated greatly; 18% of patients were intermittently negative for HCV RNA. Five patients recovered spontaneously whereas 20 developed chronicity or received interferon‐based therapy during the acute phase. Among 15 patients treated during the acute phase with peginterferon with or without ribavirin for 24 weeks, all became HCV RNA negative within 4–8 weeks, and all except two (HIV‐positive) achieved a sustained virological response. Side effects (particularly psychiatric) were common and limited treatment in 30%.Conclusions  Among 25 patients with acute HCV infection, fluctuating illness was common and spontaneous recovery occurred in only 20%. Anti‐viral treatment with a 24‐week course of peginterferon and ribavirin was highly effective, but marked by frequent and severe side effects.
Application of the WHO fracture risk assessment tool (FRAX) to predict need for DEXA scanning and treatment in patients with inflammatory bowel disease at risk of osteoporosis
Authors: Goodhand J. R. , Kamperidis N. , Nguyen H. , Wahed M. , Rampton D. S. 
Published: December 2010

Aliment Pharmacol Ther 2011; 33: 551–558SummaryBackground  Although patients with inflammatory bowel disease (IBD) are at increased risk of osteoporosis, low bone mineral density (BMD) alone confers only a modest increase in risk of fracture. The FRAX score, developed by the WHO, is a free web‐based clinical scale assessing the 10‐year fracture risk and need for lifestyle advice/reassurance, dual X‐ray absorptiometry (DEXA) scanning or preventive treatment.Aim  To assess the accuracy of pre‐BMD FRAX scores in identifying at risk IBD patients needing BMD measurement (intermediate risk) and/or therapy (high risk).Methods  We calculated FRAX scores retrospectively in 116 consecutive IBD out‐patients (81 Crohn’s disease, 35 ulcerative colitis), who were having DEXA scans in 2005–2009 because they were considered at risk of osteoporosis.Results  On DEXA scans, 47% (38/81) and 12% (10/81) patients with Crohn’s disease were osteopaenic and osteoporotic, respectively; equivalent figures for patients with UC were 34% (12/35) and 14% (5/35). The clinical FRAX score alone, when compared with the FRAX score including the BMD result, had a sensitivity of 100% (95% CI: 70–100%), specificity of 40% (95% CI: 31–50%), positive predictive value of 16% (95% CI: 9–27%) and negative predictive value of 100% (95% CI: 90–100%) in identifying those patients needing BMD measurement (intermediate risk) or preventive therapy (high risk).Conclusions  In patients with IBD perceived to be at risk of osteoporosis and/or osteopaenia, the clinical FRAX score alone can predict accurately the risk of osteoporotic fracture, and thereby reduce the need for DEXA scans and unnecessary anti‐osteoporosis treatment.