bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can current preclinical strategies for radiopharmaceutical development meet the needs of targeted alpha therapy?
Authors: Kleynhans Janke , Ebenhan Thomas , Cleeren Frederik , Sathekge Mike Machaba 
Published: April 2024

AbstractPreclinical studies are essential for effectively evaluating TAT radiopharmaceuticals. Given the current suboptimal supply chain of these radionuclides, animal studies must be refined to produce the most translatable TAT agents with the greatest clinical potential. Vector design is pivotal, emphasizing harmonious physical and biological characteristics among the vector, target, and radionuclide. The scarcity of alpha-emitting radionuclides remains a significant consideration. Actinium-225 and lead-212 appear as the most readily available radionuclides at this stage. Available animal models for researchers encompass xenografts, allografts, and PDX (patient-derived xenograft) models. Emerging strategies for imaging alpha-emitters are also briefly explored. Ultimately, preclinical research must address two critical aspects: (1) offering valuable insights into balancing safety and efficacy, and (2) providing guidance on the optimal dosing of the TAT agent.
Long-term health-related quality of life and mental health in patients with immune thrombotic thrombocytopenic purpura
Authors: Mulas Olga , Efficace Fabio , Costa Alessandro , Baldi Thomas , Zerbini Filippo , Mantovani Daniela , Morelli Emanuela , Perra Daniela , La Nasa Giorgio , Caocci Giovanni 
Published: April 2024

AbstractImmune thrombotic thrombocytopenic purpura (iTTP) is a rare and potentially life-threatening disorder. Treatment advances have lowered morbidity rates, but past acute events can still cause long-term consequences, reducing health-related quality of life (HRQoL) and determining cognitive impairment, anxiety, and depression. We aimed to investigate these aspects and the role of caplacizumab and rituximab: 39 patients were evaluated using the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), the FACIT-Fatigue, the Hospital Anxiety and Depression Scale, and the Functional Assessment in Cancer Therapy-Cognitive Function questionnaires. The median age at study inclusion was 50 years (IQR 38–60), and the median follow-up from diagnosis was 97 months (IQR 14–182); 82% of patients were female, and 36% had one or more recurrences. Caplacizumab was administered in 16 patients (41%), as well as rituximab. ITTP patients reported lower physical and mental HRQoL scores than the general population. No differences in physical or mental domains were observed between patients treated or not with caplacizumab, while those who received rituximab reported lower scores in mental health. Neurological impairment at diagnosis correlated with worse fatigue. The majority of patients (72%) reported anxiety or depression (82%). ITTP had a significant impact on the long-term cognitive function, fatigue, depression, and anxiety levels of patients, with a negative effect on their HRQoL. Our findings underscore the need to pay special attention to patients’ long-term physical and mental health, regardless of the medical treatments received.
Rheumatoid arthritis epidemiology: a nationwide study in Poland
Authors: Krajewska-Włodarczyk Magdalena , Szeląg Mateusz , Batko Bogdan , Żuber Zbigniew , Orleański Michał , Podwójcic Krzysztof , Sowiński Jakub , Jopek Jakub , Świderek Maria , Maluchnik Michał , Brzosko Marek , Śmiglewska Agata , Kwiatkowska Brygida 
Published: April 2024

AbstractTo assess the incidence and prevalence of rheumatoid arthritis (RA) in Poland for the period 2013–2021, total and dependent on gender, age, region and serological status. Information on reported National Health Fund (NHF) health services and reimbursed prescriptions were used, defining an RA patient as a person who had at least two visits in different quarters with ICD-10 code M05 or M06 and at the same time filled at least one reimbursed prescription for a drug whose active substance is methotrexate, sulfasalazine, leflunomide or was treated with biologic disease-modifying anti-rheumatic drugs (bDMRDs) or targeted synthetic DMARDs (tsDMARDs) as part of a drug program financed by the National Health Fund. The nationwide standardised incidence rate of RA in 2021 was 29 persons per 100,000 population (18 per 100,000 population of seropositive vs. 11 per 100,000 population of seronegative RA). The prevalence of RA in Poland in 2021 was 689.0 people per 100,000 population, a total of 0.7% (1.1% in women and 0.3% in men). The incidence of seronegative RA was approximately 38%. The majority of new RA diagnoses were in the sixth and seventh decades of life, irrespective of patients’ gender. The results allow RA to be classified as a disease with a significant social impact. A trend of later onset of RA has been observed, which requires special consideration of the needs of patients over 55 years of age.
How modern treatments have modified the role of surgery in pediatric low-grade glioma
Authors: Boop Scott , Shimony Nir , Boop Frederick 
Published: April 2024

AbstractLow-grade gliomas are the most common brain tumor of childhood, and complete resection offers a high likelihood of cure. However, in many instances, tumors may not be surgically accessible without substantial morbidity, particularly in regard to gliomas arising from the optic or hypothalamic regions, as well as the brainstem. When gross total resection is not feasible, alternative treatment strategies must be considered. While conventional chemotherapy and radiation therapy have long been the backbone of adjuvant therapy for low-grade glioma, emerging techniques and technologies are rapidly changing the landscape of care for patients with this disease. This article seeks to review the current and emerging modalities of treatment for pediatric low-grade glioma.
New strategy for intraoperative phonosurgical management of recurrent laryngeal nerve infiltrated by thyroid carcinoma
Authors: Peng Jieying , Zhu Guanghao , Gao Yingna , Song Xianmin , Yu Haojun , Huang Rushi , Chen Mengjie , Jiang Yafei , Sun Guodong , Li Meng , Zheng Hongliang , Wang Wei 
Published: April 2024

Abstract
Purpose
Treating an infiltration of the recurrent laryngeal nerve (RLN) by thyroid carcinoma remains a subject of ongoing debate. Therefore, this study aims to provide a novel strategy for intraoperative phenosurgical management of RLN infiltrated by thyroid carcinoma.

Methods
Forty-two patients with thyroid carcinoma infiltrating the RLN were recruited for this study and divided into three groups. Group A comprised six individuals with medullary thyroid cancer who underwent RLN resection and arytenoid adduction. Group B consisted of 29 differentiated thyroid cancer (DTC)patients who underwent RLN resection and ansa cervicalis (ACN)-to-RLN anastomosis. Group C included seven patients whose RLN was preserved.

Results
The videostroboscopic analysis and voice assessment collectively indicated substantial improvements in voice quality for patients in Groups A and B one year post-surgery. Additionally, the shaving technique maintained a normal or near-normal voice in Group C one year post-surgery.

Conclusion
The new intraoperative phonosurgical strategy is as follows: Resection of the affected RLN and arytenoid adduction is required in cases of medullary or anaplastic carcinoma, regardless of preoperative RLN function. Suppose RLN is found infiltrated by well-differentiated thyroid cancer (WDTC) during surgery, and the RLN is preoperatively paralyzed, we recommend performing resection the involved RLN and ACN-to-RLN anastomosis immediately during surgery. If vocal folds exhibit normal mobility preoperatively, the MACIS scoring system is used to assess patient risk stratification. When the MACIS score > 6.99, resection of the involved RLN and immediate ACN-to-RLN anastomosis were performed. RLN preservation was limited to patients with MACIS scores ≤ 6.99.
Abrogating PDK4 activates autophagy-dependent ferroptosis in breast cancer via ASK1/JNK pathway
Authors: Shi Wenbiao , Wang Jian , Chen Jianbin , Jin Xiaoyan , Wang Yuanfan , Yang Linjun 
Published: April 2024

Abstract
Background
Targeting ferroptosis mediated by autophagy presents a novel therapeutic approach to breast cancer, a mortal neoplasm on the global scale. Pyruvate dehydrogenase kinase isozyme 4 (PDK4) has been denoted as a determinant of breast cancer metabolism. The target of this study was to untangle the functional mechanism of PDK4 in ferroptosis dependent on autophagy in breast cancer.

Methods
RT-qPCR and western blotting examined PDK4 mRNA and protein levels in breast cancer cells. Immunofluorescence staining appraised light chain 3 (LC3) expression. Fe (2 +) assay estimated total iron level. Relevant assay kits and C11-BODIPY (591/581) staining evaluated lipid peroxidation level. DCFH-DA staining assayed intracellular reactive oxygen species (ROS) content. Western blotting analyzed the protein levels of autophagy, ferroptosis and apoptosis-signal-regulating kinase 1 (ASK1)/c-Jun N-terminal kinase (JNK) pathway-associated proteins.

Results
PDK4 was highly expressed in breast cancer cells. Knockdown of PDK4 induced the autophagy of breast cancer cells and 3-methyladenine (3-MA), an autophagy inhibitor, countervailed the promoting role of PDK4 interference in ferroptosis in breast cancer cells. Furthermore, PDK4 knockdown activated ASK1/JNK pathway and ASK1 inhibitor (GS-4997) partially abrogated the impacts of PDK4 absence on the autophagy and ferroptosis in breast cancer cells.

Conclusion
To sum up, deficiency of PDK4 activated ASK1/JNK pathway to stimulate autophagy-dependent ferroptosis in breast cancer.
Prediction of monkeypox infection from clinical symptoms with adaptive artificial bee colony-based artificial neural network
Authors: Muhammed Kalo Hamdan Ahmed , Ekmekci Dursun 
Published: April 2024

AbstractIn 2022, the World Health Organization declared an outbreak of monkeypox, a viral zoonotic disease. With time, the number of infections with this disease began to increase in most countries. A human can contract monkeypox by direct contact with an infected human, or even by contact with animals. In this paper, a diagnostic model for early detection of monkeypox infection based on artificial intelligence methods is proposed. The proposed method is based on training the artificial neural network (ANN) with the adaptive artificial bee colony algorithm for the classification problem. In the study, the ABC algorithm was preferred instead of classical training algorithms for ANN because of its effectiveness in numerical optimization problem solutions. The ABC algorithm consists of food and limit parameters and three procedures: employed, onlooker and scout bee. In the algorithm standard, artificial onlooker bees are produced as much as the number of artificially employed bees and an equal number of limit values are assigned for all food sources. In the advanced adaptive design, different numbers of artificial onlooker bees are used in each cycle, and the limit numbers are updated. For effective exploitation, onlooker bees tend toward more successful solutions than the average fitness value of the solutions, and limit numbers are updated according to the fitness values of the solutions for efficient exploration. The performance of the proposed method was investigated on CEC 2019 test suites as examples of numerical optimization problems. Then, the system was trained and tested on a dataset representing the clinical symptoms of monkeypox infection. The dataset consists of 240 suspected cases, 120 of which are infected and 120 typical cases. The proposed model's results were compared with those of ten other machine learning models trained on the same dataset. The deep learning model achieved the best result with an accuracy of 75%. It was followed by the random forest model with an accuracy of 71.1%, while the proposed model came third with an accuracy of 71%.
Pre-eruptive intramural resorption in unerupted teeth: a cone-beam computed tomography evaluation of prevalence and related factors
Authors: Ngamsom Supak , Arayapisit Tawepong , Asavanamuang Phanit , Anurakwongsri Raksayam , Sonthinane Kittikarn , Kretapirom Kornkamol 
Published: April 2024

Abstract
Objective
Pre-eruptive intramural resorption (PEIR) is defined as an abnormal, well-circumscribed radiolucency within the coronal dentin of the tooth, which is often overlooked in plain radiographs. This study aimed to investigate the prevalence of PEIR and its related factors using cone-beam computed tomography (CBCT).

Methods
CBCT images of 590 unerupted teeth were evaluated for the presence of PEIR, location of PEIR, number of lesions in the affected tooth, PEIR score, tooth angulation, tooth position, and pericoronal space. Binary logistic tests were used to analyze the association between the characteristics of PEIR and the patient’s demographic data and related factors.

Results
The tooth prevalence of PEIR was 13.6% among unerupted teeth. However, it was noteworthy that 19.2% of the unerupted teeth with PEIR were planned to be kept. PEIR was significantly associated with transverse (p = 0.020), inverted-angulated (p = 0.035), and centrally-positioned teeth (p = 0.043). The severity of PEIR was more pronounced in teeth with distal (p = 0.019), lingual (p = 0.023), or inverted-angulated (p = 0.040) positions, and in the absence of pericoronal space (p = 0.036).

Conclusion
PEIR should be suspected in transverse, inverted-angulated, centrally positioned unerupted teeth, particularly in molars, with no pericoronal space. Further monitoring through CBCT is recommended in such cases.

Clinical relevance
The management of unerupted teeth does not always involve surgical removal. Instead, they could be utilized for artificial eruption or tooth transplantation. The present study emphasizes the significance of early detection of PEIR. Clinical recommendations for screening PEIR in unerupted teeth are also proposed, which can be applied to routine plain radiographs.
Skeletal muscle dysfunction in amyotrophic lateral sclerosis: a mitochondrial perspective and therapeutic approaches
Authors: Kubat Gokhan Burcin , Picone Pasquale 
Published: April 2024

AbstractAmyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease that results in the loss of motor neurons and severe skeletal muscle atrophy. The etiology of ALS is linked to skeletal muscle, which can activate a retrograde signaling cascade that destroys motor neurons. This is why satellite cells and mitochondria play a crucial role in the health and performance of skeletal muscles. This review presents current knowledge on the involvement of mitochondrial dysfunction, skeletal muscle atrophy, muscle satellite cells, and neuromuscular junction (NMJ) in ALS. It also discusses current therapeutic strategies, including exercise, drugs, stem cells, gene therapy, and the prospective use of mitochondrial transplantation as a viable therapeutic strategy.
The role of helplines in the anti-trafficking space: examining contacts to a major ‘modern slavery’ hotline
Authors: Cockbain Ella , Tompson Lisa 
Published: April 2024

AbstractAlthough increasingly deployed worldwide, human trafficking hotlines are sorely under-researched. Situated within a complex systems framework, we conceptualise such helplines as both a product of and an influence on broader anti-trafficking ecosystems. Taking the UK as a case study, we undertook exploratory analysis of potential ‘modern slavery’ cases (n=3,613) reported to a major independent anti-trafficking helpline. We examined who seeks help, why and what follows. Contrary to stereotypes, relatively few cases involved sexual exploitation. Many case characteristics varied significantly by exploitation type. Reports about car washes and beauty services heavily influenced overall trends, likely reflecting intense public focus on these sites. Most cases involved adults. Although people self-reporting exploitation are the core target audience, only around 1 in 10 cases derived from self-reports (with higher rates for domestic servitude). We show how third-party reporters vary in their proximity to the people about whom they raise concerns – who themselves may or may not self-identify as victims and/or welcome intervention. Findings around onward action both show a whole-systems response to addressing complex needs and raise difficult tensions around risks of police involvement. Our key contributions include showing what can (and cannot) presently be assessed from such helpline data, proposing a future research agenda and providing a tangible illustration of what it means to theorise helplines as a part of a complex system of anti-trafficking activity. We highlight how their central goal of victim support can be enabled and constrained by wider policies, funding decisions and other structures.
UV-LEDs outperform actinics for standalone moth monitoring
Authors: van Deijk J. R. , Wever R. , van der Heide S. R. , Boers J. , van Deijl I. H. J. , van Grunsven R. H. A. 
Published: April 2024

AbstractWith the increasing awareness of biodiversity loss, the demand for standardized monitoring is also growing. Moths are a species rich group and can easily be monitored with traps. However the traps have to be portable to cover remote areas. The disadvantage of the commonly used Heath trap are heavy batteries and the unreliable actinic is not very energy efficient. Therefore we invented a new, portable LED trap which reliable switch on and is more energy efficient. In this study, we compared the number of attracted individuals and moth species between the standard Heath trap and a 2835 LED-strip. We also tested the aging effect after 1000 and 2000 h runtime to rule out monitoring the deterioration of the LED and compared the new 2835 strip with a brighter 5050 LED-strip. The 2835 LED attracts on average 2.3 times more moths compared to the Heath trap. This is partly caused by the energy inefficiency of the actinic whereby it only runs 2/3 of the night compared to the whole night with the 2835 LED, emphasizing energy efficiency as big advantage of LED. No difference in the total number of individuals was found after 1000 and 2000 h runtime compared to new LEDs. The 5050 LEDs attracted on average 2.0 more moths compared to the 2835 LEDs, suggesting this LED as alternative for relatively species poor regions.Implications for insect conservation The LedTrap can be used everywhere within a standardised monitoring scheme or within moth related experiments, resulting in a better understanding of their trends and preferences, which contributes to their conservation.
Exact Transport Coefficients from the Inelastic Rough Maxwell Model of a Granular Gas
Authors: Santos Andrés , Kremer Gilberto M. 
Published: April 2024

AbstractGranular gases demand models capable of capturing their distinct characteristics. The widely employed inelastic hard-sphere model (IHSM) introduces complexities that are compounded when incorporating realistic features like surface roughness and rotational degrees of freedom, resulting in the more intricate inelastic rough hard-sphere model (IRHSM). This paper focuses on the inelastic rough Maxwell model (IRMM), presenting a more tractable alternative to the IRHSM and enabling exact solutions. Building on the foundation of the inelastic Maxwell model (IMM) applied to granular gases, the IRMM extends the mathematical representation to encompass surface roughness and rotational degrees of freedom. The primary objective is to provide exact expressions for the Navier–Stokes–Fourier transport coefficients within the IRMM, including the shear and bulk viscosities, the thermal and diffusive heat conductivities, and the cooling-rate transport coefficient. In contrast to earlier approximations in the IRHSM, our study unveils inherent couplings, such as shear viscosity to spin viscosity and heat conductivities to counterparts associated with a torque-vorticity vector. These exact findings provide valuable insights into refining the Sonine approximation applied to the IRHSM, contributing to a deeper understanding of the transport properties in granular gases with realistic features.
Optical soliton solutions of complex Ginzburg–Landau equation with triple power law and modulation instability
Authors: Onder Ismail , Esen Handenur , Ozisik Muslum , Secer Aydin , Bayram Mustafa 
Published: April 2024

AbstractThis paper examines the complex Ginzburg Landau equation, which describes pulse propagation inside a fiber with the triple power law of self-phase modulation. Since the effect of parameter selection has become very important in relevant model studies recently, self-phase modulation has been added to the complex Ginzburg Landau equation, which has been studied in the literature, and it is aimed at investigating the analytical solutions of the presented equation. Adding the triple power law of the self-phase modulation parameter to the model, in addition to existing studies in the literature, emphasizes the innovative aspect and importance of the study. The first aim is to reveal bright and singular solitons using the new Kudryashov method. The new Kudryashov method is a technique that is frequently used in the literature, is effective for generating analytical solutions, provides ease of operation, and can be applied to a wide class of nonlinear partial differential equations. The second goal is to show that the obtained solutions have modulation stability. By using modulation instability analysis, the gain spectrum is formed for different parameter values. Graphic presentations support the findings. Moreover, bright and singular soliton portraits are demonstrated with 3D and 2D graphs. The novelty of the study lies in the fact that the relevant model has not been studied before with an effective method such as the new Kudryashov method, and the modulation instability has been studied for the first time.
The Truth in Social Media
Authors: Bernstein Andrés , Gomila Antoni 
Published: April 2024

AbstractIn the last chapter of In the beginning was the deed: realism and moralism in political argument, Williams raised the question of truthfulness in politics and warned that the media, particularly, television, and the market of communication in general, work in ways contrary to truthfulness -understood as the combination of the virtues of sincerity and accuracy. In this paper we would like to carry on Williams’ line of thinking in connection with the impact of the new social media platforms on politics. Where Williams focused on television, we will consider the impact of the internet public sphere. After reviewing how the digital social media encourages motivated reasoning in general, we propose to focus on two main phenomena derived from it: the rise of conspiracy theories and the moralization of politics. Conspiracy theories epitomize the risk of self-deception Williams was concerned to signal. On the other hand, the process of moralization of politics triggers sectarianism and hate for the “others”, the outgroup. Both phenomena are not exclusive of the internet sphere, but both are boosted by it, and entail a lack of interest in truth and truthfulness, and in this way they threaten the value of truth for democracy.