bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: N‐Doped, Porous TiO2 with Rutile Phase and Visible Light Sensitive Photocatalytic Activity.
Authors: Shieh Dong‐Lin , Lin Yi‐Shiue , Yeh Jia‐Hau , Chen Sian‐Cong , Lin Bo‐Chiuan , Lin Jong‐Liang 
Published: April 2012

AbstractNitrogen‐doped, porous rutile is prepared by hydrothermal reaction of TiN in HNO3 (autoclave, 100 °C, 6 h) followed by annealing in air (200 °C, 2 h).
ChemInform Abstract: Three‐Dimensional Ordered Arrays of 58x58x58 Å3 Hollow Frameworks in Ionic Crystals of M2Zn2‐Substituted Polyoxometalates.
Authors: Suzuki Kosuke , Kikukawa Yuji , Uchida Sayaka , Tokoro Hiroko , Imoto Kenta , Ohkoshi Shin‐ichi , Mizuno Noritaka 
Published: April 2012

AbstractM2Zn2‐substituted polyoxometalates with M: Co, Ni, and Zn are characterized by single crystal XRD, UV/VIS spectroscopy, and magnetic measurements.
ChemInform Abstract: Thermolabile Noble Metal Precursors: (NO)[Au(NO3)4], (NO)2[Pd(NO3)4], and (NO)2[Pt(NO3)6].
Authors: Wickleder Mathias S. , Gerlach Frauke , Gagelmann Steffen , Bruns Joern , Fenske Mandus , Al‐Shamery Katharina 
Published: April 2012

AbstractThe title compounds are suitable thermolabile precursors for the respective noble metals with the advantage that they do not lead to carbon contamination of the deposited metals.
ChemInform Abstract: Catalytic Hydrogenation with Frustrated Lewis Pairs: Selectivity Achieved by Size‐Exclusion Design of Lewis Acids.
Authors: Eros Gabor , Nagy Krisztina , Mehdi Hasan , Papai Imre , Nagy Peter , Kiraly Peter , Tarkanyi Gabor , Soos Tibor 
Published: April 2012

AbstractThe metal‐free catalytic hydrogenation of unsaturated imines, ketones, and quinolines that utilizes frustrated Lewis pair catalysts is investigated.
ChemInform Abstract: Simple Synthesis of 1,1‐Bis(trifluoromethyl)cyclopropanes.
Authors: Petrov Viacheslav A. , Marshall Will 
Published: April 2012

AbstractAn unprecedented and simple method for the synthesis of the trifluoromethylated cyclopropanes (II) is based on the reaction of readily available 2,2‐bis(trifluoromethyl)thietanes (I) with tertiary phosphines in a polar solvent.
ChemInform Abstract: Intermolecular [3 + 2] Cycloaddition of Cyclopropylamines with Olefins by Visible‐Light Photocatalysis.
Authors: Maity Soumitra , Zhu Mingzhao , Shinabery Ryan Spencer , Zheng Nan 
Published: April 2012

AbstractThe reaction proceeds with excellent regiocontrol with respect to the alkene.
ChemInform Abstract: Synthesis of Trifluorostyrene Derivatives by Palladium‐Catalyzed Cross‐Coupling of Lithium Trimethoxy(trifluorovinyl)borate with Aryl Bromides.
Authors: Duric Sasa , Schmidt Bernd M. , Ninnemann Nina M. , Lentz Dieter , Tzschucke C. Christoph 
Published: April 2012

AbstractThe convenient method employs stable, easily handled starting materials and avoids the use of toxic, dangerous, and unstable reagents.
ChemInform Abstract: The Investigation of Fluorination Reaction of p‐Substituted Benzenesulfonimides with Fluorine—Nitrogen Mixed Gas to Synthesize NFSI Analogues.
Authors: Chen Guanlong , Chen Fuli , Zhang Yan , Yang Xueyan , Yuan Xiaoming , Wu Fanhong , Yang Xianjin 
Published: April 2012

AbstractThe fluorination of p‐substituted benzenesulfonimides of type (I) with fluorine—nitrogen mixed gas is sensitive to many factors such as source of the substrate, reaction temperature, reaction scale, reaction time, pH value etc.
ChemInform Abstract: Efficient Synthesis of β‐Acetamido Ketones Catalyzed by Cobalt Sulfate Heptahydrate under Ultrasound Irradiation.
Authors: Chen Bao‐Hua , Li Ji‐Tai , Chen Guo‐Feng , Song Ya‐Li 
Published: April 2012

AbstractThe synthesis of β‐acetamido ketones of type (IV) gives considerably higher yields under ultrasound irradiation compared to conventional heating under reflux.
ChemInform Abstract: Photochemical Studies on 5‐Methylbicyclo[1.1.1]pentane Derivatives: P‐Orbital Overlap Controlled Enantioselectivity.
Authors: Ma Manling , Yang Chao , Li Bing , Shao Yutian , Zhao Guolei , Xia Wujion 
Published: April 2012

AbstractThe derivative (I) shows the best enantioselectivity in the presented Norrish/Yang photocyclization reaction.
ChemInform Abstract: Sonogashira Coupling Reactions of Bromomaleimides: Route to Alkyne/cis‐Alkene/Alkyl Maleimides: Synthesis of Luffarin X and Cacospongionolide C.
Authors: Deore Prashant S. , Argade Narshinha P. 
Published: April 2012

AbstractPd‐catalyzed treatment of bromomaleimides with terminal alkynes provides a new and general approach to alkynylmaleimides like (III).
ChemInform Abstract: Aqueous and Solvent‐Free Uncatalyzed Three‐Component Vinylogous Mukaiyama—Mannich Reactions of Pyrrole‐Based Silyl Dienolates.
Authors: Sartori Andrea , Dell'Amico Luca , Curti Claudio , Battistini Lucia , Pelosi Giorgio , Rassu Gloria , Casiraghi Giovanni , Zanardi Franco 
Published: April 2012

AbstractA catalyst and additive‐free environmentally benign Mukaiyama—Mannich reaction of silyl dienolate (I) with a wide variety of aromatic and aliphatic aldehydes and o‐methoxyaniline (III) is presented.
ChemInform Abstract: Chemoselective Intramolecular Alkylation of the Blaise Reaction Intermediates: Tandem One‐Pot Synthesis of exo‐Cyclic Enaminoesters and Their Applications Toward the Synthesis of N‐Heterocyclic Compounds.
Authors: Kim Ju Hyun , Shin Hyunik , Lee Sang‐gi 
Published: April 2012

AbstractCoupling of nitriles (I) and (VII) with Reformatsky reagents, generated from bromides (II) and (V), followed by treatment with NaN(Tms)2 allows an efficient access to exo‐cyclic enaminoesters.
ChemInform Abstract: A Chiral Phenoxyamine Magnesium Catalyst for the Enantioselective Hydroamination/Cyclization of Aminoalkenes and Intermolecular Hydroamination of Vinyl Arenes.
Authors: Zhang Xiaoming , Emge Thomas J. , Hultzsch Kai C. 
Published: April 2012

AbstractThe new chiral magnesium complex (I) catalyzes intramolecular hydroamination/cyclization reactions of several aminoalkenes (II) giving the corresponding pyrrole derivatives (III) with high enantioselectivities.
ChemInform Abstract: An Annulative Electrophilic Amination Approach to 3‐Aminobenzoheteroles.
Authors: Matsuda Naoki , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: April 2012

AbstractA mild and convenient method to prepare biologically important 3‐aminobenzofurans and 3‐aminoindoles is reported.
ChemInform Abstract: Palladium on Carbon: An Efficient, Heterogeneous and Reusable Catalytic System for Carbonylative Synthesis of N‐Substituted Phthalimides.
Authors: Khedkar Mayur V. , Khan Shoeb R. , Sawant Dinesh N. , Bagal Dattatraya B. , Bhanage Bhalchandra M. 
Published: April 2012

AbstractDouble carbonylation of o‐diiodobenzene (I) in the presence of aromatic and aliphatic amines proceeds readily in the presence of Pd—C catalyst to afford phthalimides (IV) and (VI) in high to excellent yields.
ChemInform Abstract: A Highly Efficient Friedel—Crafts Reaction of 3‐Hydroxyoxindoles and Aromatic Compounds to 3,3‐Diaryl and 3‐Alkyl‐3‐aryloxindoles Catalyzed by Hg(ClO4)2·3H2O.
Authors: Zhou Feng , Cao Zhong‐Yan , Zhang Jing , Yang Hai‐Bo , Zhou Jian 
Published: April 2012

AbstractThe use of easily available starting materials as well as a broad substrate scope make the process useful.
ChemInform Abstract: Synthesis and Biological Activity of Novel 4‐ and 6‐(1‐Alkyl/Aryl‐1H‐benzimidazol‐2‐yl)benzene‐1,3‐diols.
Authors: Karpinska Monika M. , Matysiak Joanna , Niewiadomy Andrzej , Wietrzyk Joanna , Klopotowska Dagmara 
Published: April 2012

AbstractDerivatives (IIIa)‐(IIId) show comparable antiproliferative potency to that of cisplatin.
ChemInform Abstract: An Efficient Method for the Transformation of 5‐Ylidenerhodanines into 2,3,5‐Trisubstituted‐4‐thiazolidinones.
Authors: Kaminskyy Danylo , Khyluk Dmytro , Vasylenko Olexandr , Lesyk Roman 
Published: April 2012

AbstractThree‐component reaction of mercaptoacrylic acids (I), prepared by hydrolysis of 5‐ylidenerhodanines, with arylamines and carbonyl compounds gives thiazolidinones (IV).
ChemInform Abstract: Synthesis, Characterization, and Antifungal Activity of Biaryl‐Based Bis(1,2,3‐triazoles) Using Click Chemistry.
Authors: Gaur Manoj , Goel Mayurika , Sridhar L. , Ashok Tara Devi S. , Prabhakar S. , Dureja P. , Raghunathan P. , Eswaran S. V. 
Published: April 2012

AbstractCompounds (III), (V), and (VII) exhibit moderate to good antifungal activity.
ChemInform Abstract: Microwave‐Assisted Synthesis and Antibacterial Properties of Some New 2‐Alkyl/Aryl‐(6‐substitutedcoumarin‐3‐yl)imidazo[2,1‐b] [1,3,4]thiadiazoles.
Authors: Jakhar Anshu , Makrandi J. K. 
Published: April 2012

AbstractAll new compounds are screened for their antibacterial potency.
ChemInform Abstract: Ruthenium‐Catalyzed Enantioselective Hydrogenation of Aryl‐Pyridyl Ketones.
Authors: Tao Xiaoming , Li Wanfang , Ma Xin , Li Xiaoming , Fan Weizheng , Xie Xiaomin , Ayad Tahar , Ratovelomanana‐Vidal Virginie , Zhang Zhaoguo 
Published: April 2012

AbstractThe Ru complex (I) is most efficient in the case of ortho‐substituted substrates.
ChemInform Abstract: 4,6‐Dimethylpyridine‐2,3‐dicarbonitrile and Its Reaction with N‐Acylhydrazines.
Authors: Rudenko I. V. , Kucherak A. A. , Tolmachev A. A. , Hordiyenko O. V. 
Published: April 2012

AbstractAn efficient method for the synthesis of dicarbonitrile (IV) and its conversion into pyrrolopyridinylidene carbohydrazides such as (VI) are described.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel Piperidin‐4‐ol Derivatives.
Authors: Weng Zhiyong , Wei Wei , Dong Xiaowu , Hu Yongzhou , Huang Shufang , Liu Tao , Xie Xin 
Published: April 2012

AbstractThe most potent compound in terms of CCR5 antagonistic activity is derivative (IIId).
ChemInform Abstract: Regioselective Synthesis of 2‐Substituted 3‐Diarylmethylenylpiperidines.
Authors: Chang Meng‐Yang , Lin Chung‐Han , Lee Tein‐Wei 
Published: April 2012

AbstractNBS‐mediated regioselective bromomethoxylation of the tetrasubstituted olefins (I) followed by dehydrobromination and BF3‐promoted cross‐coupling with organosilyl reagents (II) and (IV) constitutes a method for the selective α‐functionalization of N‐protected piperidines.
ChemInform Abstract: C1‐Substituted N‐Alkyl Tetrahydroisoquinoline Derivatives Through V‐Catalyzed Oxidative Coupling.
Authors: Jones Kevin M. , Karier Pol , Klussmann Martin 
Published: April 2012

AbstractA variety of nucleophiles such as nitroalkanes, ketones, heteroaromatics, and alkynes can be used in the method.
ChemInform Abstract: Synthesis of Substituted Phenazines via Palladium‐Catalyzed Aryl Ligation.
Authors: Winkler Jeffrey D. , Twenter Barry M. , Gendrineau Thomas 
Published: April 2012

AbstractPhenazines (III) are synthesized by double Buchwald—Hartwig amination of bromoanilines (II), followed by in situ oxidation.
ChemInform Abstract: An Asymmetric Ugi Three‐Component Reaction Induced by Chiral Cyclic Imines: Synthesis of Morpholine— or Piperazine—Ketocarboxamide Derivatives.
Authors: Zhu Deguang , Xia Liang , Pan Li , Li Sheng , Chen Ruijiao , Mou Yongren , Chen Xiaochuan 
Published: April 2012

AbstractTreatment of chiral cyclic imines like (I) and (VII) with acids and isocyanides allows an efficient and stereoselective access to novel morpholines.
ChemInform Abstract: Three‐Component Reaction Between Vinyl Ethers, Secondary Phosphines, and Elemental Selenium: One‐Pot Synthesis of 1‐(Alkoxy)ethyl and 1‐(Aryloxy)ethyl Phosphinodiselenoates.
Authors: Gusarova Nina K. , Artem'ev Alexander V. , Oparina Ludmila A. , Kolyvanov Nikita A. , Malysheva Svetlana F. , Vysotskaya Oksana V. , Trofimov Boris A. 
Published: April 2012

AbstractA general, straightforward, and atom‐economic method for the synthesis of the air‐ and moisture‐stable compounds (III) and (V) is presented.
ChemInform Abstract: Lignan Derivatives from the Leaves Nicotiana tabacum and their Activities.
Authors: Gao Xuemei , Li Xuesen , Yang Xinzhou , Mu Huaixue , Chen Yongkuan , Yang Guangyu , Hu Qiufen 
Published: April 2012

AbstractCompound (I) exhibits high anti‐tobacco mosaic virus and moderate anti‐HIV activities.
Electromagnetic Interference and Implanted Cardiac Devices: The Medical Environment (Part II)
Authors: Misiri Juna , Kusumoto Fred , Goldschlager Nora 
Published: April 2012

AbstractElectromagnetic interference produced by medical equipment can interact with implanted cardiac devices such as pacemakers and implantable cardioverter‐defibrillators. The most commonly observed interaction is in the operating room with electrosurgery. The risk of interactions can often be mitigated by close communication between the cardiac‐device specialist and the anesthesiology/surgical team to develop a patient‐specific strategy that accounts for factors such as type of device, type of surgery, and whether the patient is pacemaker dependent. Although magnetic resonance imaging should generally not be used in patients with implanted cardiac devices, several published guidelines provide strategies and recommendations for managing risks if magnetic resonance imaging is required with no suitable diagnostic alternatives. Other common sources of electromagnetic interference in the medical environment are ionizing radiation and left ventricular assist devices. Clin. Cardiol. 2012 DOI: 10.1002/clc.21997The authors have no funding, financial relationships, or conflicts of interest to disclose.
O‐Linked Triazolotriazines: Potent and Selective c‐Met Inhibitors
Authors: Chen Fang , Wang Ying , Ai Jing , Zhan Zhengsheng , Lv Yongcong , Liang Zhongjie , Luo Cheng , Mei Desheng , Geng Meiyu , Duan Wenhu 
Published: April 2012

AbstractThe HGF/c‐Met signaling pathway mediates a variety of important biological activities, but dysregulation of the pathway is also closely associated with poor prognosis in a wide range of human cancers. c‐Met is considered to be among the most promising therapeutic targets for anticancer drug discovery. Herein we report the discovery of a series of O‐linked triazolotriazines that show sub‐nanomolar inhibition of c‐Met activity. Among these new compounds, 6 a exhibits high c‐Met inhibitory potency in both enzymatic and cellular assays with great selectivity.
Poly(N‐Isopropylacrylamide)‐Based Microgels and Their Assemblies for Organic‐Molecule Removal from Water
Authors: Parasuraman Deepika , Sarker Avijeet K. , Serpe Michael J. 
Published: April 2012

AbstractWe review our recent efforts utilizing poly(N‐isopropylacrylamide)‐co‐acrylic acid (pNIPAm‐co‐AAc) microgels and their assemblies for the removal of an azo‐dye molecule, 4‐(2‐Hyrodxy‐1‐napthylazo) benzenesulfonic acid sodium salt (Orange II), from aqueous solutions. First, the ability of dispersed, single microgels to remove Orange II from aqueous solutions at room temperature is discussed.1 Uptake efficiency (i.e., the amount of Orange II removed from water) increased with AAc composition in the microgels, yielding a maximum uptake efficiency of 29.5 % for pNIPAm microgels with 10 % AAc. Assemblies of microgels (aggregates) were also investigated for their removal efficiency, which yielded a maximum uptake efficiency of 44.1 % at room temperature.2 Removal efficiencies for the microgels and their aggregates were also monitored at elevated temperatures, and a maximum of 56.6 % removal efficiency was achieved for unaggregated microgels, while aggregates were able to remove 73.1 % Orange II. To further explore the impact of the microgel system’s structure on function, we investigated the role microgel size in the aggregates plays on the uptake efficiency. Initial observations showed that the aggregates composed of microgels with large diameter yielded improved uptake efficiency over the aggregates composed of small diameter microgels. Langmuir sorption isotherms were fit to the data for the dye removal by the unaggregated and aggregated microgels, which showed good fits in all cases.
Recent Developments in Atom Transfer Radical Polymerization (ATRP): Methods to Reduce Metal Catalyst Concentrations
Authors: Lou Qin , Shipp Devon A. 
Published: April 2012

AbstractAtom transfer radical polymerization (ATRP) was initially developed in the mid‐1990s, and with continued refinement and use has led to significant discoveries in new materials. However, metal contamination of the polymer product is an issue that has proven detrimental to widespread industrial application of ATRP. The laboratories of K. Matyjaszewski have made significant progress towards removing this impediment, leading the development of “activators regenerated by electron transfer” ATRP (ARGET ATRP) and electrochemically mediated ATRP (eATRP) technologies. These variants of ATRP allow polymers to be produced with great molecular weight and functionality control but at significantly reduced catalyst concentrations, typically at parts per million levels. This Concept examines these polymerizations in terms of their mechanism and outcomes, and is aimed at giving the reader an overview of recent developments in the field of ATRP.
A Bombesin Copper Complex Based on a Bifunctional Cyclam Derivative
Authors: Liolios Christos C. , Zikos Christos , Fragogeorgi Eirini , Benaki Dimitra , Pelecanou Maria , Pirmettis Ioannis , Ioannidis Nikolaos , Sanakis Yiannis , Raptopoulou Catherine P. , Psycharis Vassilis , Terzis Aris , Boschetti Frédéric , Papadopoulos Minas S. , Sivolapenko Gregory , Varvarigou Alexandra D. 
Published: April 2012

AbstractThe reaction of the C‐functionalized cyclam chelating agent 1,4,8,11‐tetraazacyclotetradecane‐6‐carboxylic acid (1) with CuCl2 generated a stable and neutral complex 2, which was characterized by elemental analysis, UV/Vis and IR spectroscopy, electrospray ionization mass spectrometry (ESI‐MS), EPR spectroscopy and X‐ray crystallography. The secondary amine groups of 1 were protected to generate 3, which was further conjugated with the bombesin (BN) derivative H2N‐(Ornithine)3‐BN(2–14) by a solid phase peptide synthesis method. After cleavage from the resin and deprotection, the resulting product 5 was obtained and characterized with ESI‐MS and NMR spectroscopy, and was subsequently complexed under mild conditions with CuCl2 to generate complex 6 in high yield. Complex 6 was characterized with UV/Vis spectroscopy, ESI‐MS and EPR spectroscopy. The stability of complexes 2 and 6 was tested against cysteine, histidine and glutathione, and both complexes were found to be stable. The cyclam BN conjugate 5 and its CuII complex 6 were suitable for targeting the gastrin releasing peptide receptors (GRPrs) that are over expressed on PC‐3 cells. Both 5 and 6 showed high binding affinity to GRPrs during in vitro cell assays with human PC‐3 prostate cancer cells. The half maximal inhibitory concentration (IC50) values observed for 5 and 6 (0.30 ± 0.03 and 0.33 ± 0.03 nM, respectively) were similar to that of the [Tyr]4‐BN peptide (0.45 ± 0.04 nM), which was used as standard.
Vertical centrifugation of virgin olive oil under inert gas
Authors: Masella Piernicola , Parenti Alessandro , Spugnoli Paolo , Calamai Luca 
Published: April 2012

AbstractVirgin olive oil vertical centrifugation under inert gas (IVC) was compared with conventional vertical centrifugation in contact with air (CVC). IVC gives a strong reduction of the oil oxygenation in terms of reduced dissolved oxygen concentration and oxidative indexes (peroxide values and K232). Minor compounds (chlorophyll and total phenols) and volatile compounds were not affected by the treatment.Practical applications: A technical implementation of inertized vertical separators appears a practicable solution to preserve virgin olive oil quality traits. This can be easily implemented both by the mill owner with homemade adjustment of the existing machines and by plant industrial manufacturers.
Altering the scissile fatty acid binding site of Candida antarctica lipase A by protein engineering for the selective hydrolysis of medium chain fatty acids
Authors: Brundiek Henrike , Padhi Santosh Kumar , Kourist Robert , Evitt Andrew , Bornscheuer Uwe T. 
Published: April 2012

AbstractCandida antarctica lipase A (CAL‐A) is the first representative of a new subclass of lipases because of its unique cap domain. The acyl‐binding tunnel – having a short alternative binding region – is mainly formed by this domain. In order to create CAL‐A variants with a high specificity for medium chain length (MCL) fatty acids (C6–C12), we used rational protein design to block the primary acyl‐binding tunnel of CAL‐A at position G237, which is near the junction to the alternative binding pocket. By closing the junction to the main tunnel, CAL‐A variants (G237A/L/V/Y) have been created, which are highly specific for medium chain fatty acids (MCFAs) as determined by chain length profiles with p‐nitrophenyl esters and triacylglycerides. Especially the CAL‐A variants G237L/V/Y, in which the junction to the primary tunnel is completely closed, show a distinct preference for the hydrolysis of hexanoate esters. Hydrolytic activity for substrates with a chain length >C6 is suppressed extensively in mutants G237L/V/Y. Therefore, these highly MCL specific CAL‐A variants may represent interesting biocatalysts for the production of MCL‐derived esters for the food, flavor, and fragrance industry.Practical application: Since medium chain fatty acids (MCFAs: C6‐C10) and their corresponding triacylglycerides (MCTs) provide quick access to energy and have been considered to be less implicated in the accumulation of body fat than long chain fatty acids, they represent interesting food additives. As functional oils, they are part of weight loss diets or are used in clinical nutrition. In the food industry MCTs are also utilized as storage stabilizing agents in cooking products, as release agents in food processing or as flavor diluent. Another interesting field of application of MCFA derived compounds, especially of C6 esters and alcohols, is as ingredients in flavors and fragrances. The CAL‐A variants described in this study can be used for the biocatalytic synthesis of these compounds.
Double‐Blind Placebo‐Controlled Trial of Quetiapine in Anorexia Nervosa
Authors: Powers Pauline S. , Klabunde Megan , Kaye Walter 
Published: April 2012

AbstractObjectiveOur objective is to determine whether quetiapine was superior to placebo in increasing weight or reducing core symptoms of anorexia nervosa as assessed by the Yale–Brown–Cornell Eating Disorder Scale and the Eating Disorder Inventory‐2.MethodParticipants were randomised to 8 weeks of quetiapine or placebo.ResultsThere are 21 participants who signed informed consent, 15 were randomised, 14 returned for at least one visit after receiving drug and 10 completed the study. There were no differences between drug and placebo in questionnaire scores, weight or measures of anxiety or depression.DiscussionThere was no difference between quetiapine and placebo on weight gain or core symptoms. Small effect sizes suggest that a higher number of participants would not increase significant differences between groups. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.
A model for OFDM signals with applications
Authors: Kotzer Igal , Har‐Nevo Smadar , Sodin Sasha , Litsyn Simon 
Published: April 2012

ABSTRACTA novel model for constant energy constellation (the data is drawn from equi‐energy symbols) discrete time orthogonal frequency‐division multiplexing (OFDM) signal is presented. On the basis of this model, the moments of the OFDM signal's envelope maximum and the moments of the energy of the clipped portion of the signal are computed. It is also shown that the rate at which the expected value of the maximum scales with the length of the signal coincides with Halasz's result. Simulations are presented, which show that this model gives much better results than the conventional Gaussian model in approximation of statistical properties of an OFDM signal. Copyright © 2012 John Wiley & Sons, Ltd.