bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALISIS PEMROGRAMAN CNC MILLING PADA PEMBUATAN DISC BRAKE MENGGUNAKAN CAD CAM
Authors: Fauzan Novansyah  , Abizar Haris 
Published: April 2024

Perkembangan dan kemajuan teknologi saat ini tidak dipungkiri sudah begitu pesat yang dimana hal ini memaksa penggunaan teknologi untuk bisa mengoptimalkan proses produksi yang cepat. Hal tersebut diiringi dengan pesatnya perkembangan dunia otomotif saat ini dan disertai dengan berbagai inovasi terbaru, yang dimana semakin banyak pula pengguna kendaraan pada saat ini. Tujuan penelitian ini adalah untuk menghasilkan sebuah NC file, parameter pemesinan dan estimasi waktu pengerjaan pada proses pembuatan discbrake menggunakan mesin CNC. Penelitian ini menggunakan metode penelitian desain dan pengembangan (design development research) yang dimana metode ini bertujuan untuk mengembangkan suatu perangkat instrumen untuk menciptakan sebuah produk dan alat. Metode ini secara umum digunakan untuk sebuah studi mengenai perancangan, pengembangan dan evaluasi yang dijabarkan secara sistematis dan dengan kaidah tertentu. Hasil menunjukan berdasarkan keseluruhan proses CAM maka didapatkan sebuah estimasi waktu untuk pembuatan disc brake yaitu selama 44 menit 37,97 detik. Kemudian dari proses CAM tersebut juga menghasilkan sebuah NC file atau file kode. Setelah NC file sudah dilakukan penyesuaian dan estimasi waktu pengerjaanpun sudah optimal maka program dapat diserahkan kepada operator untuk dilakukan proses pemesinan.
Visual attention and phonological processing in children with developmental language disorder
Authors: Lara-Díaz María Fernanda , Beltrán Rojas Judy Costanza , Aponte Rippe Yennifer 
Published: April 2024

IntroductionDevelopmental Language Disorder (DLD) is a neurobiological condition characterized by insufficient language and communication development, with no underlying physical, sensory, or cognitive explanations. A prominent feature among children with DLD is their struggle with phonological processing, a pivotal skill for later reading proficiency. Recent research suggests that children with DLD may also exhibit impairments in various non-linguistic cognitive abilities, including memory, attention, and perception. Of particular importance is visual attention, which plays a critical role in integrating visual perceptual information with diverse cognitive and linguistic processes.ObjectiveTo characterize visual attention during phonological processing tasks in Colombian children with DLD.MethodologyThis study employed a cross-sectional descriptive experimental design involving 20 children diagnosed with Developmental Language Disorder (DLD) and 20 children without language difficulties. All participants underwent language, vocabulary, and phonological awareness tests. Additionally, an experimental task utilizing the eye-tracking method was designed and administered to measure phonological processing with phonological and lexical distractors.ResultsChildren with DLD exhibited diminished performance on phonological awareness tasks, as evidenced by their lower scores. This was further supported by the experimental phonological processing task, where an interference effect was observed in the presence of lexical distractors for word recognition, but not with phonological distractors.ConclusionChildren with DLD demonstrated deficiencies in both phonological awareness and visual attention skills during linguistic and phonological processing tasks. They also exhibit reduced sensitivity in identifying phonological relations such as rhyme. The study discusses these findings along with their clinical implications, emphasizing the importance of assessing online processing abilities in children with DLD and considering the influence of other cognitive abilities on their linguistic performance.
Pulmonary artery banding: a 20-year experience at a tertiary care center in a developing country
Authors: Ghoussaini Racha , Zareef Rana , Makarem Adham , Younis Nour , Al Hassan Sally , El Rassi Issam , Obeid Munir , Bitar Fadi , Arabi Mariam 
Published: April 2024

AimPulmonary artery banding serves as an important palliative procedure used for the management of several congenital heart lesions. This study aims to describe a 20-year experience of pulmonary artery banding at a tertiary care center in a developing country.MethodsThis is a retrospective chart review of patients who underwent pulmonary artery banding over a 20-year period between January 2000 and July 2020 in a tertiary care center in a developing country. Data regarding demographics, indications, diagnosis, echocardiographic findings, postoperative complications, hospital stay, and outcomes were recorded.ResultsA total of 143 patients underwent pulmonary artery banding between 2000 and 2020, with a decrease from approximately 15 surgeries per year in 2012 to 1–2 surgeries a year in 2020. At the time of banding, the median age of patients was approximately 90 days [interquartile range, IQR, 30–150 days]. Four patients (2.8%) died during the band placement. No significant association was observed between baseline characteristics or type of heart defect at presentation and postoperative morbidity and mortality.ConclusionPulmonary artery banding remains useful in a subset of congenital heart lesions and as a surgical palliation, with relatively low mortality, allowing postponement of total correction to a higher weight. This technique continues to be valuable in developing countries or for heart surgical programs with limited resources.
Predictive value of bone turnover markers and thyroid indicators for bone metabolism in GD patients after treatment
Authors: Su Mengxue , Chai Jinyan , Zheng Wei , Jia Qiang , Tan Jian , He Yajing , Zhang Ruiguo , Men Jianlong , Liu Wei , Shi Tao , Ren Jing , Dong Liyan , Liu Luyi , Meng Zhaowei 
Published: April 2024

PurposeTo investigate the relationship between bone turnover markers (BTMs) and thyroid indicators in Graves’ disease (GD) and to further assess predictive value of changes in early stage retrospectively.MethodsWe studied 435 patients with GD and 113 healthy physical examiners retrospectively and followed up these two groups of patients after 6 months. We investigated the correlations between BTMs and other 15 observed factors, and analyzed the predictive value of FT3 and FT4 before and after treatment (FT3-P/FT3-A, FT4-P/FT4-A) on whether BTMs recovered.ResultsThe levels of thyroid hormones and BTMs in GD group were significantly higher than those in control group (P &lt; 0.05) and decreased after 6 months of treatment. FT3, W, Ca and ALP were independent factors in predicting the elevation of OST. Duration of disease, FT3, TSH and ALP were independent factors in predicting the elevation of P1NP. Age, duration of disease, TRAb and ALP were independent factors in predicting the elevation of CTX-1. The AUC of FT3-P/FT3-A and FT4-P/FT4-A for predicting OST recovery were 0.748 and 0.705 (P &lt; 0.05), respectively, and the cut-off values were 0.51 and 0.595. There was no predictive value for P1NP and CTX-1 recovery (P &gt; 0.05).ConclusionBTMs were abnormally elevated in GD and were significantly correlated with serum levels of FT3, FT4, TRAb, Ca, and ALP. FT3 decreased more than 51% and FT4 dropped more than 59.5% after 6 months of treatment were independent predictors for the recovery of BTMs in GD.
Pregnancy outcomes in women with primary ovarian insufficiency in assisted reproductive technology therapy: a retrospective study
Authors: Sun Bo , Li Lu , Zhang Yile , Wang Fang , Sun Yingpu 
Published: April 2024

PurposeThis study aims to retrospectively estimate cumulative reproductive outcomes in women with primary ovarian insufficiency (POI) in assisted reproductive technology (ART) therapy.MethodsA total of 139 patients diagnosed with POI were reviewed in this study. Firstly, they were divided into two groups according to oocyte origin: using their own oocytes (OG group) or accepting oocyte donations (OD I group). Secondly, the patients were split depending on the pregnancy outcome. In the OG group, nine patients decided to use others’ oocytes after a failure of attempting to use their own, and this population was the oocyte donation II group (OD II group).ResultsThere were 88 patients who used their own oocytes, while 51 patients accepted oocyte donations. In the OG group, there are only 10 (7.2%) patients who got pregnant, and patients in the OD group had worse hormone levels (FSH 71.37 ± 4.18 vs. 43.98 ± 2.53, AMH 0.06 ± 0.04 vs. 1.15 ± 0.15, and AFC 0.10 ± 0.06 vs. 1.15 ± 0.15) and more years of infertility (5.04 ± 0.48 vs. 3.82 ± 0.30), which explained why they choose oocyte donation. In all the three groups, baseline characteristics were comparable between pregnant women and non-pregnant women. Of the 10 pregnant patients in the OG group, four of them used luteal-phase short-acting long protocol and had pregnancies successfully in their first cycles.ConclusionOvarian stimulation in POI women requires more cost and time. For those with a stronger desire to have genetic offspring, luteal-phase short-acting long protocol may help them obtain pregnancy rapidly.
Dissecting the shared genetic architecture between endometriosis and polycystic ovary syndrome
Authors: Tan Hangjing , Long Panpan , Xiao Hongmei 
Published: April 2024

BackgroundPrevious study suggested evidence for coexistence and similarities between endometriosis and polycystic ovary syndrome (PCOS), but it is unclear regarding the shared genetic architecture and causality underlying the phenotypic similarities observed for endometriosis and PCOS.MethodsBy leveraging summary statistics from public genome-wide association studies regarding endometriosis (European-based: N=470,866) and PCOS (European-based: N=210,870), we explored the genetic correlation that shared between endometriosis and PCOS using linkage disequilibrium score regression. Shared risk SNPs were derived using PLACO (Pleiotropic analysis under composite null hypothesis) and FUMA (Functional Mapping and Annotation of Genetic Associations). The potential causal association between endometriosis and PCOS was investigated using two-sample Mendelian randomization (MR). Linkage disequilibrium score for the specific expression of genes analysis (LDSC-SEG) were performed for tissue enrichment analysis. The expression profiles of the risk gene in tissues were further examined.ResultsA positive genetic association was observed between endometriosis and PCOS. 12 significant pleiotropic loci shared between endometriosis and PCOS were identified. Genetic associations between endometriosis and PCOS were particularly enriched in uterus, endometrium and fallopian tube. Two-sample MR analysis further indicated a potential causative effect of endometriosis on PCOS, and vice versa. Microarray and RNA-seq verified the expressions of SYNE1 and DNM3 were significantly altered in the endometrium of patients with endometriosis or PCOS compared to those of control subjects.ConclusionOur study indicates the genetic correlation and shared risk genes between PCOS and endometriosis. These findings provide insights into the potential mechanisms behind their comorbidity and the future development of therapeutics.
Induction of diabetes by Tacrolimus in a phenotypic model of obesity and metabolic syndrome
Authors: Teixidó-Trujillo Silvia , Porrini Esteban , Menéndez-Quintanal Luis Manuel , Torres-Ramírez Armando , Fumero Cecilia , Rodríguez-Rodríguez Ana Elena 
Published: April 2024

IntroductionThe pathogenesis of Post-Transplant Diabetes Mellitus (PTDM) is complex and multifactorial and it resembles that of Type-2 Diabetes Mellitus (T2DM). One risk factor specific to PTDM differentiates both entities: the use of immunosuppressive therapy. Specifically, Tacrolimus interacts with obesity and insulin resistance (IR) in accelerating the onset of PTDM. In a genotypic model of IR, the obese Zucker rats, Tacrolimus is highly diabetogenic by promoting the same changes in beta-cell already modified by IR. Nevertheless, genotypic animal models have their limitations and may not resemble the real pathophysiology of diabetes. In this study, we have evaluated the interaction between beta-cell damage and Tacrolimus in a non-genotypic animal model of obesity and metabolic syndrome.MethodsSprague Dawley rats were fed a high-fat enriched diet during 45 days to induce obesity and metabolic dysregulation. On top of this established obesity, the administration of Tacrolimus (1mg/kg/day) during 15 days induced severe hyperglycaemia and changes in morphological and structural characteristics of the pancreas.ResultsObese animals administered with Tacrolimus showed increased size of islets of Langerhans and reduced beta-cell proliferation without changes in apoptosis. There were also changes in beta-cell nuclear factors such as a decrease in nuclear expression of MafA and a nuclear overexpression of FoxO1A, PDX-1 and NeuroD1. These animals also showed increased levels of pancreatic insulin and glucagon.DiscussionThis model could be evidence of the relationship between the T2DM and PTDM physiopathology and, eventually, the model may be instrumental to study the pathogenesis of T2DM.
Identification of PANoptosis-related subtypes, construction of a prognosis signature, and tumor microenvironment landscape of hepatocellular carcinoma using bioinformatic analysis and experimental verification
Authors: Ouyang Guoqing , Li Qiuyun , Wei Yangnian , Dai Wenbin , Deng Haojian , Liu Youli , Li Jiaguang , Li Mingjuan , Luo Shunwen , Li Shuang , Liang Yunying , Pan Guandong , Yang Jianqing , Gan Tao 
Published: April 2024

BackgroundHepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. PANoptosis is a recently unveiled programmed cell death pathway, Nonetheless, the precise implications of PANoptosis within the context of HCC remain incompletely elucidated.MethodsWe conducted a comprehensive bioinformatics analysis to evaluate both the expression and mutation patterns of PANoptosis-related genes (PRGs). We categorized HCC into two clusters and identified differentially expressed PANoptosis-related genes (DEPRGs). Next, a PANoptosis risk model was constructed using LASSO and multivariate Cox regression analyses. The relationship between PRGs, risk genes, the risk model, and the immune microenvironment was studies. In addition, drug sensitivity between high- and low-risk groups was examined. The expression profiles of these four risk genes were elucidate by qRT-PCR or immunohistochemical (IHC). Furthermore, the effect of CTSC knock down on HCC cell behavior was verified using in vitro experiments.ResultsWe constructed a prognostic signature of four DEPRGs (CTSC, CDCA8, G6PD, and CXCL9). Receiver operating characteristic curve analyses underscored the superior prognostic capacity of this signature in assessing the outcomes of HCC patients. Subsequently, patients were stratified based on their risk scores, which revealed that the low-risk group had better prognosis than those in the high-risk group. High-risk group displayed a lower Stromal Score, Immune Score, ESTIMATE score, and higher cancer stem cell content, tumor mutation burden (TMB) values. Furthermore, a correlation was noted between the risk model and the sensitivity to 56 chemotherapeutic agents, as well as immunotherapy efficacy, in patient with. These findings provide valuable guidance for personalized clinical treatment strategies. The qRT−PCR analysis revealed that upregulated expression of CTSC, CDCA8, and G6PD, whereas downregulated expression of CXCL9 in HCC compared with adjacent tumor tissue and normal liver cell lines. The knockdown of CTSC significantly reduced both HCC cell proliferation and migration.ConclusionOur study underscores the promise of PANoptosis-based molecular clustering and prognostic signatures in predicting patient survival and discerning the intricacies of the tumor microenvironment within the context of HCC. These insights hold the potential to advance our comprehension of the therapeutic contribution of PANoptosis plays in HCC and pave the way for generating more efficacious treatment strategies.
A multi-omics approach to investigate characteristics of gut microbiota and metabolites in hypertension and diabetic nephropathy SPF rat models
Authors: Lu Jinjing , Gong Xiaoying , Zhang Chenlu , Yang Tengfei , Pei Dongmei 
Published: April 2024

BackgroundImbalance in intestinal microbiota caused by microbial species and proportions or metabolites derived from microbes are associated with hypertension, as well as diabetic nephropathy. However, the involvement of the intestinal microbiota and metabolites in hypertension and diabetic nephropathy comorbidities (HDN) remains to be elucidated.MethodsWe investigated the effects of intestinal microbiota on HDN in a rat model and determined the abundance of the intestinal microbiota using 16S rRNA sequencing. Changes in fecal and serum metabolites were analyzed using ultra-high-performance liquid chromatography-mass spectrometry.ResultsThe results showed abundance of Proteobacteria and Verrucomicrobia was substantially higher, whereas that of Bacteroidetes was significant lower in the HDN group than in the sham group. Akkermansia, Bacteroides, Blautia, Turicibacter, Lactobacillus, Romboutsia, and Fusicatenibacter were the most abundant, and Prevotella, Lachnospiraceae_NK4A136_group, and Prevotella_9 were the least abundant in the HDN group. Further analysis with bile acid metabolites in serum showed that Blautia was negatively correlated with taurochenodeoxycholic acid, taurocholic acid, positively correlated with cholic acid and glycocholic acid in serum.ConclusionsThese findings suggest that the gut microbiota and metabolites in feces and serum substantially differed between the HDN and sham groups. The F/B ratio was higher in the HDN group than in the sham group. Blautia is potentially associated with HDN that correlated with differentially expressed bile acid metabolites, which might regulate the pathogenesis of HDN via the microorganism–gut–metabolite axis.
Advanced fructo-oligosaccharides improve itching and aberrant epidermal lipid composition in children with atopic dermatitis
Authors: Kim Sukyung , Kang Bae-Gon , Sa Soonok , Park Se Young , Ryu Kyungheon , Lee Jinyoung , Park Boram , Kwon Mijeong , Kim Yeonghee , Kim Jiwon , Shin Sanghee , Jang Sehun , Kim Byung Eui , Bae Jaewoong , Ahn Kangmo , Liu Kwang-Hyeon , Kim Jihyun 
Published: April 2024

IntroductionThe effects of fructo-oligosaccharides (FOS) on atopic dermatitis (AD) have not been determined.MethodsIn a randomized, double-blind, placebo-controlled trial, children with AD aged 24 months to 17 years received either advanced FOS containing 4.25 g of 1-kestose or a placebo (maltose) for 12 weeks.ResultsThe SCORAD and itching scores were reduced in patients treated with both FOS (all p &lt; 0.01) and maltose (p &lt; 0.05 and p &lt; 0.01). Sleep disturbance was improved only in the FOS group (p &lt; 0.01). The FOS group revealed a decreased proportion of linoleic acid (18:2) esterified omega-hydroxy-ceramides (EOS-CERs) with amide-linked shorter chain fatty acids (C28 and C30, all p &lt; 0.05), along with an increased proportion of EOS-CERs with longer chain fatty acids (C32, p &lt; 0.01).DiscussionFOS may be beneficial in alleviating itching and sleep disturbance, as well as improving skin barrier function in children with AD.
Extended residual learning with one-shot imitation learning for robotic assembly in semi-structured environment
Authors: Wang Chuang , Su Chupeng , Sun Baozheng , Chen Gang , Xie Longhan 
Published: April 2024

IntroductionRobotic assembly tasks require precise manipulation and coordination, often necessitating advanced learning techniques to achieve efficient and effective performance. While residual reinforcement learning with a base policy has shown promise in this domain, existing base policy approaches often rely on hand-designed full-state features and policies or extensive demonstrations, limiting their applicability in semi-structured environments.MethodsIn this study, we propose an innovative Object-Embodiment-Centric Imitation and Residual Reinforcement Learning (OEC-IRRL) approach that leverages an object-embodiment-centric (OEC) task representation to integrate vision models with imitation and residual learning. By utilizing a single demonstration and minimizing interactions with the environment, our method aims to enhance learning efficiency and effectiveness. The proposed method involves three key steps: creating an object-embodiment-centric task representation, employing imitation learning for a base policy using via-point movement primitives for generalization to different settings, and utilizing residual RL for uncertainty-aware policy refinement during the assembly phase.ResultsThrough a series of comprehensive experiments, we investigate the impact of the OEC task representation on base and residual policy learning and demonstrate the effectiveness of the method in semi-structured environments. Our results indicate that the approach, requiring only a single demonstration and less than 1.2 h of interaction, improves success rates by 46% and reduces assembly time by 25%.DiscussionThis research presents a promising avenue for robotic assembly tasks, providing a viable solution without the need for specialized expertise or custom fixtures.
Effects of joint screening for prostate, lung, colorectal, and ovarian cancer – results from a controlled trial
Authors: Fan Zeyu , Zhang Yu , Yao Qiaoling , Liu Xiaomin , Duan Hongyuan , Liu Ya , Sheng Chao , Lyu Zhangyan , Yang Lei , Song Fangfang , Huang Yubei , Song Fengju 
Published: April 2024

BackgroundAlthough screening is widely used to reduce cancer burden, untargeted cancers are frequently missed after single cancer screening. Joint cancer screening is presumed as a more effective strategy to reduce overall cancer burden.MethodsGender-specific screening effects on PLCO cancer incidence, PLCO cancer mortality, all-neoplasms mortality and all-cause mortality were evaluated, and meta-analyses based on gender-specific screening effects were conducted to achieve the pooled effects. The cut-off value of time-dependent receiver-operating-characteristic curve of 10-year combined PLCO cancer risk was used to reclassify participants into low- and high-risk subgroups. Further analyses were conducted to investigate screening effects stratified by risk groups and screening compliance.ResultsAfter a median follow-up of 10.48 years for incidence and 16.85 years for mortality, a total of 5,506 PLCO cancer cases, 1,845 PLCO cancer deaths, 3,970 all-neoplasms deaths, and 14,221 all-cause deaths were documented in the screening arm, while 6,261, 2,417, 5,091, and 18,516 outcome-specific events in the control arm. Joint cancer screening did not significantly reduce PLCO cancer incidence, but significantly reduced male-specific PLCO cancer mortality (hazard ratio and 95% confidence intervals [HR(95%CIs)]: 0.88(0.82, 0.95)) and pooled mortality [0.89(0.84, 0.95)]. More importantly, joint cancer screening significantly reduced both gender-specific all-neoplasm mortality [0.91(0.86, 0.96) for males, 0.91(0.85, 0.98) for females, and 0.91(0.87, 0.95) for meta-analyses] and all-cause mortality [0.90(0.88, 0.93) for male, 0.88(0.85, 0.92) for female, and 0.89(0.87, 0.91) for meta-analyses]. Further analyses showed decreased risks of all-neoplasm mortality was observed with good compliance [0.72(0.67, 0.77) for male and 0.72(0.65, 0.80) for female] and increased risks with poor compliance [1.61(1.40, 1.85) for male and 1.30(1.13, 1.40) for female].ConclusionJoint cancer screening could be recommended as a potentially strategy to reduce the overall cancer burden. More compliance, more benefits. However, organizing a joint cancer screening not only requires more ingenious design, but also needs more attentions to the potential harms.Trial registrationNCT00002540 (Prostate), NCT01696968 (Lung), NCT01696981 (Colorectal), NCT01696994 (Ovarian).