bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Epstein‐Barr virus LMP‐1 and Hodgkin lymphoma LMP‐1 mechanisms in Hodgkin lymphoma development
Authors: Oliveira Leonam Oliver Durval , Costa Igor Brasil , Quaresma Juarez Antônio Simões 
Published: June 2024

AbstractHodgkin lymphoma is histologically characterised by the presence of Hodgkin (H) and Reed‐Sternberg (RS) cells originating from germinal centre B‐cells rearranged in the IgV gene. The formation of multinucleated RS cells is a product of telomere organisation in a process initiated by telomere aggregate accumulation in mononuclear H cells and may be mediated by latent membrane protein 1 (LMP‐1) expression. LMP‐1 is the main oncoprotein of EBV and supports several tumourigenic processes. LMP‐1 may rescue proapoptotic B‐cells through downregulation of B‐cell receptor (BCR) components, mimicking and inducing multiple distinct B‐cell signalling pathways to promote proliferation and survival, such as Janus kinase‐signal transducer and activator of transcription (JAK‐STAT), nuclear factor‐kappa b (NF‐кB), and cellular MYC (c‐MYC), and inducing telomere instability mainly through Telomere repeat binding factor 2 (TRF2) downregulation to promote the formation of multinucleated RS cells. This review presents recent discoveries regarding the influence of LMP‐1 on the surviving cellular signalling, genomic instability and mecanical formation of HRS cells.
Long‐term treatments alter acidification, fertility and carbon in soils of the Fork Mountain long‐term soil productivity experiment
Authors: Adams Mary Beth , Rau Benjamin M. , Peterjohn William T. , Fowler Zach , Kelly Charlene 
Published: June 2024

AbstractHistoric atmospheric acidic deposition resulting from the combustion of fossil fuels may alter the pools of important nutrients and base cations in sensitive forest soils. This raises concern that chronic acidic deposition, particularly when coupled with intensive forest biomass harvesting, may diminish long‐term soil fertility, forest productivity, and carbon storage potential. To address these concerns, the Fork Mountain long‐term soil productivity experiment was initiated in 1996 at the Fernow Experimental Forest, West Virginia. The replicated experimental design consists of 16 plots (0.2 ha) that receive one of four treatments: (1) whole‐tree harvesting (removal of all aboveground biomass, WT plots); (2) whole‐tree harvesting + ammonium‐sulfate fertilization (WT + NS plots); (3) whole‐tree harvesting + ammonium‐sulfate fertilization + dolomitic lime (WT + NS + Lime plots); and (4) untreated reference plots. We present forest floor and soil chemistry responses after ∼25 years of treatment and evaluate the temporal changes to illuminate these results. Soil acidification has occurred, and base cation movement through the soil profile was observed, with effective cation exchange capacity increasing slightly in the deepest soil horizon by the end of the 25 years. However, some of our hypotheses were not supported. In particular, soil C did not increase over time with fertilization/soil acidification but was mainly altered by WT harvesting, as were other nutrients. Dolomitic lime provided some amelioration of acidification, but surprisingly, most of the changes in base cations appeared to be the results of Mg, not Ca, likely due to greater tree requirements and uptake of Ca.
Sufficiency as relations of enoughness
Authors: Hartmann Eric 
Published: June 2024

AbstractAn expanding body of literature discusses the importance of sufficiency for sustainable development. However, conceptual vagueness stands in the way of the practical application of sufficiency as a sustainability strategy. The main contribution of this paper is the introduction of the concept of relations of enoughness, building on the general notion of ‘enough’, which is prevalent in sufficiency literature. Relations of enoughness will be explained based on the widespread use of sufficiency advocating for changes and reductions of individual consumption with the goal to reduce environmental impacts such as carbon dioxide emissions. Diverse uses and understandings of sufficiency can be united in a shared structure of ‘enough/too much/too little of X regarding Y’. Relations of enoughness can be connected to sustainability by expanding them into chains of enoughness, which serve as a conceptual foundation for the sustainable consumption corridor approach. Finally, the premises of sufficiency and potential for further research are discussed.
Impact of the COVID-19 Pandemic on International Cutaneous Squamous Cell Carcinoma Incidence: A Systematic Review and Meta-Analysis
Authors: Wall James , Gadsby-Davis Kieran , Mistry Khaylen , Levell Nick J. , Venables Zoe C. 
Published: June 2024

Abstract

Background
Non-melanoma skin cancer (NMSC) is the most common cancer globally in white ethinicity populations, and cutaneous squamous cell carcinoma (cSCC) is the second most common subtype. The COVID-19 pandemic severely impacted public and private healthcare systems. Many studies have reported reduced cancer diagnoses during the pandemic. The impact of the COVID-19 pandemic on global cSCC and NMSC incidence is poorly reported.

Objectives
The aim was to conduct a systematic review and meta-analysis to assess the impact of the COVID-19 pandemic on global cSCC and NMSC incidence rates, compared with 2019 incidence rates. Two primary outcome measures were used: crude incidence rate ratios (CIRR) and age-standardised incidence rate ratios (ASIRR).

Methods
A structured search was undertaken on 23 March 2023 using grey literature and four electronic databases: MEDLINE, CINAHL, EMBASE and Web of Science. Studies published before January 2020 were excluded. A quality assessment was undertaken using A. Lomas quality assessment tool. CIRR outcomes were synthesised in a meta-analysis, while ASIRR outcomes were narratively synthesised.

Results
Fourteen cancer registries were included, capturing data from 13 countries across Europe. Variation was observed in NMSC and cSCC incidence across the cancer registries. Pooled cSCC crude incidence rates in 2020 were equal to crude incidence rates in 2019 (cSCC-CIRR 1.00 (95% confidence interval (CI) 0.94–1.06). In 2021, the pooled result indicated a non-significant 8% increase in cSCC crude incidence rates, compared with 2019 (cSCC-CIRR 1.08 (95% CI 0.98–1.19). Significant reductions were reported in NMSC incidence across all meta-analyses in 2020 and 2021 compared with 2019. Heterogeneity was observed across most pooled estimates (I2&gt;75%).

Conclusion
There was a lack of high quality data on cSCC incidence rates recorded during the pandemic outside of Europe. The COVID-19 pandemic resulted in no significant changes in cSCC incidence across Europe. By contrast, NMSC incidence fell across Europe following the pandemic. Significant reductions in pooled NMSC incidence rates may reflect a delay in basal cell carcinoma presentation, diagnosis and treatment. Although annual incidence rates for cSCC were not affected by the pandemic, delays in treatment may still have occurred, which may result in poorer outcomes yet to be fully understood.
Compressive behavior of steel slag fine aggregate concrete under impact loading
Authors: Liu Qiuyu , Xue Gang , Dong Wei , Li Jingjun 
Published: June 2024

AbstractTo investigate the compressive behavior of steel slag fine aggregate concrete (SSC) under impact loading, the normal concrete and steel slag fine aggregate concrete with varying steel slag fine aggregate (SSA) contents were prepared and a Split Hopkinson Pressure Bar (SHPB) with a diameter of 100 mm was used for the dynamic compression testing under various strain rates. The microstructure characteristics of concrete specimens were observed by scanning electron microscopy to investigate the impact behavior changes mechanism of SSC under dynamic loading. The research results indicate that the compressive strength, DIF, and impact toughness of the specimens exhibit significant strain rate effects, all of which increase with the increase of strain rate. At similar strain rates, both impact toughness and dynamic compressive strength show an upward trend with the increase of steel slag content, while DIF decreases with the increase of steel slag content. The microstructure of SSC is denser, and the hydration product of SSA fills the internal defects of concrete and significantly enhances the interface transition zone (ITZ) between fine aggregates and cement matrix, which has an enhancement effect on impact toughness and the dynamic compressive strength of concrete. The empirical formulas were proposed based on the testing results to predict the DIF of SSC with various SSA contents. The compression constitutive models considering strain rate and steel slag content of SSC were established, and the fitting consequences with the test results accord rather well.
Digital threads for sustainable concrete: A prototype traceability system
Authors: White Callum , Forsdyke Jessica , Harrison Mark , Desnerck Pieter , Lees Janet M. 
Published: June 2024

AbstractAchieving traceability of concrete materials is a crucial step toward promoting sustainable concrete use. This includes creating accurate Environmental Product Declarations, minimizing mistakes during concrete placement, and improving understanding of the relationship between concrete constituents and performance. Despite these benefits, effective traceability for concrete materials has not yet been achieved in the laboratory environment or within wider practice. This work sets out a digital thread for concrete use and the functional requirements for a traceability framework for adoption in a laboratory environment. Traceable resource units (TRUs) are identified, and the primary critical tracking events for each TRU are described. A prototype traceability system is developed to link the necessary properties, constituent material data, production information, and performance results for concrete materials. The prototype system incorporates a novel inkjet printer QR code fingerprinting solution that is demonstrated to be highly effective for concrete specimens and for various media, including paper and metal, used to transport and store raw concrete constituent materials. A laboratory test series demonstrated a 100% readability rate with the proposed QR fingerprinting solution according to standard measures. This work advances knowledge of the appropriate traceable resource units and critical tracking events within concrete practice, develops effective marking procedures and forms a prototype constituent‐to‐product traceability system.
Machine learning applications in vadose zone hydrology: A review
Authors: Li Xiang , Nieber John L. , Kumar Vipin 
Published: June 2024

AbstractMachine learning (ML) has been broadly applied for vadose zone applications in recent years. This article provides a comprehensive review of such developments. ML applications for variables corresponding to different complex vadose zone processes are summarized mostly in a prediction context. By analyzing and assessing these applications, we discovered extensive usages of classic ML models with relatively limited applications of deep learning (DL) approaches in general. We also recognized a lack of benchmark datasets for soil property research as well as limited integration of physics‐based vadose zone principles into the ML approaches. To facilitate this interdisciplinary research of ML in vadose zone characterization and processes, a paradigm of knowledge‐guided machine learning is suggested along with other data‐driven and ML model‐based research suggestions to advance future research.
Energy Transition Subsidies
Authors: de Vries Annick , Werner Gijsbert , Wijlhuizen Elsenoor , Toom Victor , Bovens Mark , Hulscher Suzanne 
Published: June 2024

AbstractThis chapter takes a closer look at the distributive effects of three energy transition subsidies in the Netherlands. We chose these three schemes because they each target different groups: businesses, homeowners and minimum wage earners. We first discuss how the various subsidies work and how they are funded. We then consider which distributive principles we can identify in these three schemes. We explain how other distributive justice considerations and principles could also have been deployed.
Procedural Justice and Distributive Issues
Authors: de Vries Annick , Werner Gijsbert , Wijlhuizen Elsenoor , Toom Victor , Bovens Mark , Hulscher Suzanne 
Published: June 2024

AbstractThis chapter uses the example of the yellow vests in France. The example shows that a just climate policy is about more than the fair distribution of costs and benefits. The way policies are made is also a matter of justice. We therefore examine the theme of procedural justice, and in particular the justice of the policymaking process. We pay special attention to how citizens are involved.
Public Perspectives of Distribution Issues
Authors: de Vries Annick , Werner Gijsbert , Wijlhuizen Elsenoor , Toom Victor , Bovens Mark , Hulscher Suzanne 
Published: June 2024

AbstractIn this chapter, we examine what citizens themselves consider to be just distributions of climate costs. We do this in two ways. We first discuss the existing research on this topic, and then present the results of our own research into public perspectives of distributive justice. A key finding is that more than three-quarters of respondents consider fair burden sharing to be important; often more important than reducing carbon emissions. However, this is not yet adequately reflected in current climate policy.
Distributive Justice in Climate Policy
Authors: de Vries Annick , Werner Gijsbert , Wijlhuizen Elsenoor , Toom Victor , Bovens Mark , Hulscher Suzanne 
Published: June 2024

AbstractThe final chapter concludes that there is currently insufficient systematic attention to distributive justice in Dutch climate policy. Various distributive principles are often overlooked in policymaking. The key message therefore is that all climate policy should take the fair distribution of climate costs into account. In addition to effectiveness and legality, climate measures should also be assessed from the perspective of justice. Failure to do so could erode public support for climate policy, and so delay or even prevent the implementation of the policy measures.
On the absence of supergravity solutions for localized, intersecting sources
Authors: Bardzell Jacob , Federico Kevin , Smith Danielle , Wrase Timm 
Published: June 2024

Abstract
For decades intersecting D-branes and O-planes have been playing a very important role in string phenomenology in the context of particle physics model building and in the context of flux compactifications. The corresponding supergravity equations are hard to solve so generically solutions only exist in a so-called smeared limit where the delta function sources are replaced by constants. We are showing here that supergravity solutions for two perpendicularly intersecting localized sources in flat space do not exist for a generic diagonal metric Ansatz. We show this for two intersecting sources with p = 1, 2, 3, 4, 5, 6 spatial dimensions that preserve 8 supercharges, and we allow for fully generic fluxes.
Casimir effect and holographic dual of wedges
Authors: Miao Rong-Xin 
Published: June 2024

Abstract
This paper investigates the Casimir effect of a wedge and its holographic dual. We prove that the displacement operator universally determines the wedge Casimir effect in the smooth limit. Besides, we argue that the wedge Casimir energy increases with the opening angle and test it with several examples. Furthermore, we construct the holographic dual of wedges in AdS/BCFT in general dimensions. We verify that our proposal can produce the expected Casimir effect within smooth and singular limits. We observe that the Casimir energy density of a wedge increases with the brane tension. Next, we discuss the wedge contribution to holographic entanglement entropy and find it increases with the opening angle, similar to the wedge Casimir energy. Finally, we briefly discuss the holographic polygon in AdS3/BCFT2 and its generalization to higher dimensions.
Electroweak phase transition with a double well done doubly well
Authors: Agrawal Prateek , Blasi Simone , Mariotti Alberto , Nee Michael 
Published: June 2024

Abstract
We revisit the electroweak phase transition in the scalar singlet extension of the standard model with a ℤ2 symmetry. In significant parts of the parameter space the phase transition occurs in two steps — including canonical benchmarks used in experimental projections for gravitational waves. Domain walls produced in the first step of the transition seed the final step to the electroweak vacuum, an effect which is typically neglected but leads to an exponentially enhanced tunnelling rate. We improve previous results obtained for the seeded transition, which made use of the thin-wall or high temperature approximations, by using the mountain pass algorithm that was recently proposed as a useful tool for seeded processes. We then determine the predictions of the seeded transition for the latent heat, bubble size and characteristic time scale of the transition. Differences compared to homogeneous transitions are most pronounced when there are relatively few domain walls per hubble patch, potentially leading to an enhanced gravitational wave signal. We also provide a derivation of the percolation criteria for a generic seeded transition, which applies to the domain wall seeds we consider as well as to strings and monopoles.
Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models
Authors: Baek Hye Suk , Hong Victor Sukbong , Kang Hyunsu , Lee Sang-Jin , Lee Jin-Young , Kang Hyunju , Jeong Seungik , Jung Hyunho , Park Jong Wook , Kwon Taeg Kyu , Son Chang-Nam , Kim Sang Hyon , Lee Jinho , Kim Ki-Suk , Kim Shin 
Published: June 2024

AbstractRheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder characterized by joint destruction due to synovial hypertrophy and the infiltration of inflammatory cells. Despite substantial progress in RA treatment, challenges persist, including suboptimal treatment responses and adverse effects associated with current therapies. This study investigates the anti-rheumatic capabilities of the newly identified multi-protein kinase inhibitor, KMU-11342, aiming to develop innovative agents targeting RA. In this study, we synthesized the novel multi-protein kinase inhibitor KMU-11342, based on indolin-2-one. We assessed its cardiac electrophysiological safety using the Langendorff system in rat hearts and evaluated its toxicity in zebrafish in vivo. Additionally, we examined the anti-rheumatic effects of KMU-11342 on human rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), THP-1 cells, and osteoclastogenesis in RAW264.7 cells. KMU-11342 demonstrated the ability to inhibit LPS-induced chemokine inhibition and the upregulation of pro-inflammatory cytokines, cyclooxygenase-2, inducible nitric oxide synthase, p-IKKα/β, p-NF-κB p65, and the nuclear translocation of NF-κB p65 in RA-FLS. It effectively suppressed the upregulation of NLR family pyrin domain containing 3 (NLRP3) and caspase-1 cleavage. Furthermore, KMU-11342 hindered the activation of osteoclast differentiation factors such as RANKL-induced TRAP, cathepsin K, NFATc-1, and c-Fos in RAW264.7 cells. KMU-11342 mitigates LPS-mediated inflammatory responses in THP-1 cells by inhibiting the activation of NLRP3 inflammasome. Notably, KMU-11342 exhibited minimal cytotoxicity in vivo and electrophysiological cardiotoxicity ex vivo. Consequently, KMU-11342 holds promise for development as a therapeutic agent in RA treatment.
Otud6b induces pulmonary arterial hypertension by mediating the Calpain-1/HIF-1α signaling pathway
Authors: Liu Yu , Tang Bailin , Wang Hongxin , Lu Meili 
Published: June 2024

AbstractPulmonary hypertension (PAH) is a cardiopulmonary disease in which pulmonary artery pressure continues to rise, leading to right heart failure and death. Otud6b is a member of the ubiquitin family and is involved in cell proliferation, apoptosis and inflammation. The aim of this study was to understand the role and mechanism of Otud6b in PAH. C57BL/6 and Calpain-1 knockout (KO) mice were exposed to a PAH model induced by 10% oxygen. Human pulmonary artery endothelial cells (HPACEs) and human pulmonary artery smooth muscle cells (HPASMCs) were exposed to 3% oxygen to establish an in vitro model. Proteomics was used to determine the role of Otud6b and its relationship to Calpain-1/HIF-1α signaling. The increased expression of Otud6b is associated with the progression of PAH. ROtud6b activates Otud6b, induces HIF-1α activation, increases the production of ET-1 and VEGF, and further aggravates endothelial injury. Reducing Otud6b expression by tracheal infusion of siOtud6b has the opposite effect, improving hemodynamic and cardiac response to PAH, reducing the release of Calpain-1 and HIF-1α, and eliminating the pro-inflammatory and apoptotic effects of Otud6b. At the same time, we also found that blocking Calpain-1 reduced the effect of Otud6b on HIF-1α, and inhibiting HIF-1α reduced the expression of Calpain-1 and Otud6b. Our study shows that increased Otud6b expression during hypoxia promotes the development of PAH models through a positive feedback loop between HIF-1α and Calpain-1. Therefore, we use Otud6b as a biomarker of PAH severity, and regulating Otud6b expression may be an effective target for the treatment of PAH.
Graphical Abstract
Association between medial meniscal extrusion and knee structural progression in adults with symptomatic knee osteoarthritis — a prospective cohort study
Authors: Zeng Mengjie , Cicuttini Flavia M. , Wluka Anita E. , Jones Graeme , Hill Catherine L. , Ding Changhai , Wang Yuanyuan 
Published: June 2024

Abstract
Objective
To examine the association between medial meniscal extrusion and structural progression in adults with symptomatic knee osteoarthritis (OA).

Methods
This prospective cohort study examined 176 participants with symptomatic knee OA recruited into a randomised controlled trial. The participants underwent magnetic resonance imaging (MRI) of the study knee at baseline and approximately 2 years later. Meniscal extrusion, tibial cartilage volume, and tibiofemoral bone marrow lesions (BMLs) were measured from MRI using validated methods.

Results
Participants with medial meniscal extrusion ≥ 3 mm had a higher prevalence of lateral tibiofemoral BMLs at baseline (OR = 2.21, 95% CI 1.06–4.61, p = 0.035), and those with medial meniscal extrusion 2–3 mm had a higher likelihood of lateral BML worsening over 2 years (OR = 3.76, 95% CI 1.35–10.52, p = 0.011), compared with those with medial meniscal extrusion < 2 mm. Participants with stable medial meniscal extrusion had a lower likelihood of lateral BML worsening compared with those with regression of medial meniscal extrusion over 2 years (OR = 0.20, 95% CI 0.07–0.56, p = 0.002). There were no associations between medial meniscal extrusion and tibial cartilage volume or medial tibiofemoral BMLs.

Conclusions
Our study showed associations between medial meniscal extrusion and baseline prevalence and worsening over 2 years of lateral tibiofemoral BMLs in people with symptomatic knee OA. Although the reasons for the lack of associations in the medial compartment are not clear, our results suggest a role of medial meniscal extrusion in predicting structural progression in lateral knee OA and that meniscal extrusion might be a potential target in the management of knee OA.