bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquisition of Resistance to PEGylated Branched Polyethylenimine Increases Pseudomonas Aeruginosa Susceptibility to Aminoglycosides
Authors: Best William , Ferrell Maya , Boris Andrew , Heydarian Neda , Panlilio Hannah , Rice Charles V. 
Published: May 2024

AbstractPEGylated branched polyethylenimine (PEG‐BPEI) has antibacterial and antibiofilm properties. Exposure to PEG‐BPEI through serial passage leads to resistant P. aeruginosa strains. The minimum inhibitory concentration (MIC) of 600 Da BPEI and PEGylated 600 Da BPEI (PEG‐BPEI) in the wild‐type PAO1 strain is 16 μg/ml while, after 15 serial passages, the MIC increased to 1024 μg/mL. An additional 15 rounds of serial passage in the absence of BPEI or PEG‐BPEI did not change the 1024 μg/mL MIC. Gentamicin, Neomycin, and Tobramycin, cationic antibiotics that inhibit protein synthesis, have a 16–32 fold reduction of MIC values in PEG350‐BPEI resistant strains, suggesting increased permeation. The influx of these antibiotics occurs using a self‐mediated uptake mechanism, suggesting changes to the outer membrane Data show that resistance causes changes in genes related to outer membrane lipopolysaccharide (LPS) assembly. Mutations were noted in the gene coding for the polymerase Wzy that participates in the assembly of the O‐antigen region. Other mutations were noted with wbpE and wbpI of the Wbp pathway responsible for the enzymatic synthesis of ManNAc(3NAc)A in the LPS of P. aeruginosa. These changes suggest that an altered gene product could lead to PEG‐BPEI resistance. Nevertheless, the increased susceptibility to aminoglycosides could prevent the emergence of PEG‐BPEI resistant bacterial populations.
Inhibiting the Aggregation of Aβ by Natural Product Molecules
Authors: Bai Si‐Cong , Wang Ye‐Cheng , Li Xin‐Zhong , Li Gao 
Published: May 2024

AbstractThe abnormal aggregation of Aβ has been considered one of the primary causative factors for Alzheimer's disease. Diverse molecular entities have been developed to mitigate the formation of toxic Aβ aggregates within the brain by inhibiting Aβ aggregation. Recognizing that many FDA‐approved drugs are derived from natural products, we present a summary of recent discoveries involving natural product molecules with inhibitory effects on Aβ aggregation. By consolidating these findings, our review offers researchers a concise overview of the latest advancements in natural product‐based interventions for Alzheimer's disease.
Early histological transformation of follicular lymphoma to diffuse large B‐cell lymphoma indicating adverse survival: A population‐based analysis and validation
Authors: Li Zi‐Hua , Zhang Min‐Yue , Federico Massimo , Civallero Monica , Manni Martina , Alonso‐Alvarez Sara , Hou Jian , Huang Hong‐Hui 
Published: May 2024

AbstractIntroductionThe histological transformation (HT) of follicular lymphoma (FL) is a crucial biological event. The study aimed to evaluate the incidence, clinicial characteristics, prognosis and impact of HT time on survival of FL transforming to diffuse large B‐cell lymphoma in population‐based large‐scale cohorts.MethodsA retrospective cohort study of FL with HT was performed in the Surveillance, Epidemiology, and End Results database. The Hematological Malignancy Research Network FL cohort and Aristotle study FL cohort were used to assess the external validity.ResultsAmong 44,127 FL cases from the Surveillance, Epidemiology, and End Results database, 1311 cases were pathology‐proven recorded to transform to diffuse large B‐cell lymphoma. The cumulative rates of HT at 5, 10, and 15 years after FL diagnosis were estimated to be 1.19%, 2.93%, and 5.01%, respectively. Significantly worse overall survival and cancer‐specific survival were exhibited in patients with HT than those without HT. Early HT (transformation of FL within 48 months after FL diagnosis [TOD48]) was an independent predictor for adverse overall survival of HT patients, regardless of treatment modalities before transformation. The adverse prognostic effect of TOD48 was validated in the Hematological Malignancy Research Network cohort and Aristotle study cohort. Older age (>75 years) and B symptoms within FL at diagnosis were the independent risk factors of TOD48. Furthermore, a novel prognostic model combining TOD48 with Follicular Lymphoma International Prognostic Index (TOD48‐FLIPI) was constructed and validated for risk stratification.ConclusionTOD48 was a risk indicator of HT, and the novel prognostic model "TOD48‐FLIPI" for HT patients was proposed.
A six‐year comprehensive review of eye cytology cases received at a tertiary level hospital
Authors: Connelly Courtney F. , Desai Niyati , Cimic Adela , Gonzalez Abel A. , Baskota Swikrity Upadhyay 
Published: May 2024

AbstractBackgroundOcular cytology is an effective method of diagnosing infective, benign, and malignant ocular disease processes due to easy accessibility and rapid turnaround time. However, these specimens pose significant diagnostic challenges due to rarity of the specimen type, sparse diagnostic material available for ancillary workup, and unfamiliarity of the diagnostic entities by the cytopathologist.MethodsThis study conducted a 6‐year comprehensive review of 65 eye cytology cases received at a tertiary level hospital. Cytopathologic diagnoses of “negative for malignancy” and “atypical” were categorized as negative findings (70.8%, n = 46) and diagnoses of “suspicious for malignancy” and “positive for malignancy” were categorized as positive findings (23.1%, n = 15). A 44.6% (n = 29) of cases had subsequent histopathology and/or flow cytometry diagnoses. Premalignant and malignant lesions detected on histopathology were considered as significant findings. Statistical analysis was performed to evaluate the concordance of ocular cytology with associated histopathology and/or flow cytometry diagnoses.ResultsThe accuracy of final cytology‐histopathology and/or cytology‐flow cytometry diagnoses in this cohort of cases is 86.2%. The sensitivity and specificity of ocular diagnosis by cytology are 66.6% and 100%, respectively. The positive and negative predictive values of ocular diagnosis by cytology are 100% and 80.9%, respectively.ConclusionOcular cytology is a fast, effective, and sensitive method for diagnosing ocular pathology specimens. Familiarity with these specimen types by cytopathologists can help in diagnosing ocular diseases effectively on small, challenging cytologic preparations.
Hydrological changes in a plain basin in central Argentina following expansion of rainfed agriculture and climate change
Authors: Guerra Juan Carlos , Nosetto Marcelo Daniel 
Published: May 2024

AbstractThe characterization of long‐term streamflow in regions undergoing climatic change and agricultural expansion is relevant for achieving sustainable development goals and for assessing the vulnerability of water‐dependent populations and agricultural activities. The objective of this work was to characterize the temporal patterns of water yield in the plain basin of the Carcarañá River (33,063 km2), located in central Argentina and to analyse its relationship with a fast expansion of rainfed cultivation and climate change. The streamflow data for the period 1980–2020 were analysed in conjunction with climatic data (rainfall, reference evapotranspiration), satellite data (NDVI) and cropping statistics (sown area of summer crops) data. The annual water yield averaged ~10% of the rainfall and showed a clear upward trend throughout the study period, both in absolute terms and relative to rainfall (i.e., runoff coefficient), which was not explained by rainfall or reference evapotranspiration temporal patterns. Conversely, we found that the trend in water yield was positively associated with the agricultural area (p < 0.05), which more than doubled during the study period (from 29% to 66%). Likewise, the mean NDVI of the basin, a proxy for primary productivity and vegetation transpiration, has decreased steadily over the last 20 years (p < 0.05). The separation between base flow and quick flow suggested that both flows increased during the analysed period (p < 0.05), though the latter would have been more relevant in explaining the trend observed in total flow. Taken together, our results suggest that agricultural expansion, rather than climate change, is the dominant factor explaining the hydrological changes observed in the study basin. Understanding the key role of land use in shaping the hydrology of a landscape is critical to developing policies and practices for more efficient and sustainable use of environmental resources.
Revisiting the success of co‐management in forest protected areas of Bangladesh: Untangling the interplay of power, participation, and community empowerment
Authors: Baten Mohammed Abdul 
Published: May 2024

AbstractThis narrative review critically assesses the implementation and purported success of co‐management in forest management in Bangladesh. Co‐management has gained global popularity, celebrated for its participatory approach to natural resource conflict resolution, yet critiqued for potential design flaws, susceptibility to elite capture, and perpetuating power imbalances in predominantly top‐down management cultures. Despite two decades of application and reports of positive outcomes in managing forest protected areas of Bangladesh, concerns persist regarding the authenticity of its success and sustainability, particularly in terms of power dynamics and effective community participation in decision‐making processes. The review delves into these aspects, revealing instances where successes might be superficial, overlooking the underlying issues of power disparity among stakeholders. It highlights the crucial role of enhancing social capital within co‐management frameworks to foster institutionalization and sustainability. Recommendations include advancing robust collaboration and communication, alongside the adoption of adaptive management practices to navigate the complex interplay of natural, social, and institutional challenges.
Prognostic impact of plasma volume status during hospital admission in patients with acute decompensated heart failure
Authors: Hoshika Yu , Kubota Yoshiaki , Nishino Takuya , Shiomura Reiko , Shibuya Junsuke , Nakata Jun , Miyachi Hideki , Tara Shuhei , Iwasaki Yu‐Ki , Yamamoto Takeshi , Asai Kuniya 
Published: May 2024

AbstractAimsPlasma volume status (PVS), a measure of plasma volume, has been evaluated as a prognostic marker for chronic heart failure. Although the prognostic value of PVS has been reported, its significance in patients with acute decompensated heart failure (ADHF) admitted to the cardiovascular intensive care unit (CICU) remains unclear. In this study, we examined the relationship between PVS and long‐term mortality in patients with ADHF admitted to the CICU.MethodsBetween January 2018 and December 2020, 363 consecutive patients with ADHF were admitted to the Nippon Medical School Hospital CICU. Of the 363 patients, 206 (mean age, 74.9 ± 12.9 years; men, 64.6%) were enrolled in this study. Patients who received red blood cell transfusions, underwent dialysis, were discharged from the CICU or died in the hospital were excluded from the study. We measured the PVS of the patients at admission, transfer to the general ward (GW) and discharge using the Kaplan–Hakim formula. The patients were assigned to four groups according to the quartiles of their PVS measured at each of the three abovementioned timepoints. We examined the association between PVS and all‐cause mortality during the observation period (1134 days). The primary endpoint of this study was all‐cause mortality.ResultsThe Kaplan–Meier analysis showed that the high PVS group had a significantly higher mortality rate at admission, transfer to the GW and discharge than the other groups (log‐rank test: P = 0.016, P = 0.005 and P < 0.001, respectively). Univariate Cox regression analysis showed that age, body mass index, history of heart failure, use of beta‐blockers, albumin level, blood urea nitrogen level, N‐terminal pro‐brain natriuretic peptide level and left ventricular ejection fraction were significantly different among the PVS groups and thus were not significant prognostic factors for ADHF. Furthermore, the multivariate analysis revealed that PVS at discharge [hazard ratio (HR) = 1.06 (1.00–1.12), P = 0.048] was an independent poor prognostic factor for ADHF.ConclusionsThis study highlights the effect of PVS measured at different timepoints on the prognoses of ADHF patients. Regular assessment of PVS, particularly at discharge, is crucial for optimising patient management and achieving favourable outcomes in cases of ADHF.
Phase Separation of ϵ‐Fe2O3 and BaFe12O19 in a Synthesis Combining Reverse‐Micelle and Sol‐Gel Techniques
Authors: MacDougall Jessica , Tokoro Hiroko , Yoshikiyo Marie , Namai Asuka , Ohkoshi Shin‐ichi 
Published: May 2024

AbstractEpsilon iron oxide (ϵ‐Fe2O3) and magnetoplumbite barium ferrite (BaFe12O19) are well‐known hard ferrites. For one synthesis method of ϵ‐Fe2O3, combining reverse‐micelle and sol‐gel techniques, Ba ions are used to accelerate the formation of nanorod‐shaped ϵ‐Fe2O3. On the other hand, in synthesis of BaFe12O19 both Ba and Fe ions are used to form the final product. However, the coexistence of these two ferrites has not been reported by any synthesis. Herein, we investigated the effect of Ba ions on the final product for the synthesis combining reverse‐micelle and sol‐gel techniques. At a low Ba ion ratio of [Ba]/[Fe]=0.2, ϵ‐Fe2O3 nanorods are formed, while at higher Ba ion ratios ([Ba]/[Fe]=0.4, 1, 2), BaFe12O19 appears. The phase diagram at 1000 °C shows that at a Ba ion ratio of [Ba]/[Fe]=1, the ratio of ϵ‐Fe2O3 and BaFe12O19 is almost 1 : 1. The diagram shows intermediates between these two phases do not form, indicating a phase separation of ϵ‐Fe2O3 and BaFe12O19. During the sintering process of this synthesis, initially perovskite‐type Ba2Fe2O5 and γ‐Fe2O3 nanoparticles form. Then, in areas where γ‐Fe2O3 nanoparticles are gathered around Ba2Fe2O5 and react, BaFe12O19 is formed, whereas in areas lacking Ba2Fe2O5, ϵ‐Fe2O3 nanorods are formed within Ba‐ion containing silica glass.
Linear π‐Extension of Acridone by the Fusion of Cyclobutadienoid
Authors: Li Jieyu , Wang Weifan , Zhang Gang 
Published: May 2024

AbstractThe functionalization of small aromatic heterocycles is a straight and efficient method to access large polycyclic conjugated molecules. However, due to its unique reactivity, the derivatization of acridone usually gives the product in the angular shape and is difficult to obtain the linear ones. Here we report the direct functionalization of acridone to generate its linearly fused derivatives containing cyclobutadienoid via the palladium‐catalyzed arene‐(oxa)norbornene annulation followed by the dehydrated aromatization. The experimental characterizations demonstrate that the antiaromatic cyclobutadienoid ring can extend the molecular conjugation. Theoretical calculations reveal the weakened aromaticity of neighboring benzenoid rings of cyclobutadienoid with no influence on the electronic structure of central pyridone. The molecular stability is enhanced in comparison to that of linear acridone derivatives containing only six‐membered rings.
Multi‐input integrative neural network for soil seismic response modeling at KiK‐net downhole array sites
Authors: Li Lin , Jin Feng , Huang Duruo , Wang Gang 
Published: May 2024

AbstractPrediction of the soil seismic response is of primary importance for geotechnical earthquake engineering. Conventional physics‐based models such as the finite element method (FEM) often face challenges due to inherent model assumptions and uncertainties of model parameters. Furthermore, these physics‐based models require significant computational resources, particularly when simulating seismic responses across numerous soil sites. In this study, a multi‐ input integrative neural network is developed for predicting soil seismic response based on the recorded data from a large number of downhole array sites. Ground motions, seismic event information, and wave velocity structures of the sites are utilized as input data in the proposed neural network, enabling the model to adapt to various site conditions. Comparative assessments against state‐of‐the‐art FEM models demonstrate that the proposed models exhibit superior prediction performance with increased efficiency. Furthermore, the pre‐training technique, a transfer learning method, is employed to predict the seismic response at new stations. By fine‐tuning the pre‐trained model derived from the extensive dataset with limited recorded data from new stations, high‐precision seismic response predictions can be realized, illustrating the adaptability and efficacy of the proposed approach in data‐scarce conditions.
Identifying factors that predict the onset and persistence of fasting for weight control: Prospective findings
Authors: Linardon Jake 
Published: May 2024

AbstractObjectiveFasting for weight control is an under‐studied behaviour implicated in eating disorders. However, little is known about what factors account for its onset and persistence.MethodThis study sought to identify risk and maintenance factors for fasting among 1025 women recruited through an eating disorder self‐help platform who completed study measures at baseline and 6 month follow‐up. Univariate and multivariate logistic regressions were performed to test which variables at baseline predicted the onset (vs. stably asymptomatic) and persistence (vs. remission) of fasting at follow‐up.ResultsUnivariate models showed that higher baseline overvaluation, dissatisfaction, fear of weight gain, generalised and social anxiety, depression, self‐esteem deficits and eating disorder symptoms (inflexible eating rules, driven exercise) predicted greater likelihood of fasting onset. Only fear of weight gain and depressive symptoms remained significant in the multivariate model. Higher baseline overvaluation, fear of weight gain, driven exercise, inflexible eating rules, and depression predicted greater likelihood of fasting persistence in univariate models. An adherence to inflexible eating rules and overvaluation remained significant in the multivariate model.ConclusionFindings shed new light on factors that may account for the development and maintenance of fasting, which have implications for guiding effective interventions targeting this behaviour.
The potential preventive effect of probiotics, prebiotics, and synbiotics on cardiovascular risk factors through modulation of gut microbiota: A review
Authors: Ghanbari Fahimeh , Hasani Samira , Aghili Zahra Sadat , Asgary Sedigheh 
Published: May 2024

AbstractCardiovascular diseases (CVDs) are a significant contributor to global morbidity and death, underscoring the importance of their prevention and treatment. The association between the development and progression of CVD and several risk factors has been extensively studied. Among these risk factors, the gut microbiota has garnered considerable attention of the scientific community during the last two decades. In particular, dysbiosis is directly associated with many risk factors of CVD in the host, such as diabetes. Prior research has demonstrated a robust correlation between dysbiosis and the development of CVD. Probiotics, prebiotics, and synbiotics are considered important regulators of microbiota imbalances as they increase the colonization of beneficial bacteria and thereby alter the gut microbiota. Although these beneficial effects of biotics are now widely recognized, new evidence has demonstrated that target therapy of the microbiota affects many other organs, including the heart, through a process commonly referred to as the gut–heart axis. In this review, we will discuss the potential benefits of probiotics, prebiotics, and synbiotics for the beneficial effects on cardiovascular disease by modulating gut microbiota.
Propolis as a functional food and promising agent for oral health and microbiota balance: A review study
Authors: Etebarian Arghavan , Alhouei Barbod , Mohammadi‐Nasrabadi Fatemeh , Esfarjani Fatemeh 
Published: May 2024

AbstractBee Propolis has been used for its therapeutic properties, including anti‐inflammatory, antibacterial, antifungal, and immune‐stimulating properties, for centuries as a functional food. This study reviewed the effectiveness of propolis as a functional food on oral‐related diseases as a rich bioflavonoid produced by honey bees. A literature search was conducted to identify studies published that investigated the effects of propolis on oral health and its ability to treat related diseases. The search was performed in electronic databases using relevant keywords. Initially, 3429 studies were identified through database searching, and based on the inclusion and exclusion criteria, 22 articles were eligible to be included. Reviewing the articles, propolis was recognized as a functional food and promising agent to balance oral microbiota and prevent oral diseases due to its effectiveness on related bacteria, its anti‐inflammatory properties, and its activity against Porphyromonas gingivalis and Actinomyces Oris allowed it to be an effective substance to prevent periodontal diseases. Based on our findings, Propolis is a desirable preventive option for various oral health conditions, including dental caries and periodontal diseases. Therefore, it is recommended to be consumed as a functional food in our daily diet, which can reduce the risk of oral disease and improve oral health.
Exposure to cigarette taxes as a teenager and the persistence of smoking into adulthood
Authors: Friedson Andrew , Li Moyan , Meckel Katherine , Rees Daniel I. , Sacks Daniel W. 
Published: May 2024

AbstractAre teenage and adult smoking causally related? Recent anti‐tobacco policy is predicated on the assumption that preventing teenagers from smoking will ensure that fewer adults smoke, but direct evidence in support of this assumption is scant. Using data from three nationally representative sources and instrumenting for teenage smoking with cigarette taxes experienced at ages 14–17, we document a strong positive relationship between teenage and adult smoking: deterring 10 teenagers from smoking through raising cigarette taxes roughly translates into 5 fewer adult smokers. We conclude that efforts to reduce teenage smoking can have long‐lasting consequences on smoking participation and, presumably, health.
A comparative study of transcervical, endoscope‐assisted transcervical, and endoscope‐assisted transoral resection of retrostyloid space schwannomas
Authors: Zhang Diekuo , Yan Helei , Chen Huihong , Huang Donghai , Wang Xingwei , Jiang Weihong , Zhang Xin , Lu Shanhong , Liu Yong 
Published: May 2024

AbstractBackgroundThe aim of this retrospective study was to compare the efficacy of transcervical (TC), endoscope‐assisted transoral (TO), and endoscope‐assisted TC for resection of retrostyloid space schwannomas.MethodsThe study included patients who underwent complete resection of schwannomas by only one surgical approach. The data we collected included tumor size, estimated blood loss, postoperative complications, and so on. Statistical analysis was performed using one‐way analysis of variance and Fisher's exact test.ResultsThe study collected 85 patients with tumors mostly located at the oropharyngeal level who were followed up 6 months at least. The results showed that endoscope‐assisted TO had certain advantages over others. Additionally, the endoscope‐assisted TO set the lowest incidence of neurological complications.ConclusionOur findings demonstrate that for team with rich experience in the skull base surgery, endoscope‐assisted TO is a superior option compared to the other two groups for resection of retrostyloid space schwannomas, with the better preservation of neurological function.