bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multimodal MRI study of XNKQ acupuncture for limb dysfunction after ischemic stroke: a randomized controlled study protocol
Authors: Tian Chunlei , Xiao Lingyong , Li Ruiyu , Chang Yinghui , Lv Zhe , Li Lanping , Zhao Shiqing , Dai Xiaoyu 
Published: May 2024

IntroductionLimb motor dysfunction is one of the challenges in rehabilitation after cerebral ischemic stroke (CIS) and greatly affects the quality of life of patients. This study aims to investigate the central mechanisms of the curative effect with multimodal magnetic resonance imaging (MRI), which will provide additional evidence to support the application of Xingnao Kaiqiao (XNKQ) acupuncture.Methods and analysisThis trial is a randomized controlled trial. Patients who meet the criteria will be recruited and randomly divided into 2 groups. One group will receive acupuncture treatment and another group will not receive acupuncture treatment. Both groups will receive conventional treatment. In addition, 20 healthy individuals will be recruited who will not receive any treatment. The total course of treatment is 14 days. The primary outcome is multimodal MRI analysis. For safety assessment, adverse events will be observed and recorded.Ethics and disseminationThe study involving human subjects was reviewed and approved by the Ethics Committee of IRB of The First Teaching Hospital of Tianjin University of TCM (TYLL2023[K]031). This study complied with the Declaration of Helsinki. Written informed consent about this study was provided by the participants. The results of this study will be published in a peer-reviewed journal.Clinical trial registrationChinese Clinical Trial Registration Center (ChiCTR2300078315) https://www.chictr.org.cn/.
Social capital and healthy eating among two ethnic minority groups in Yunnan Province, Southwest China: the mediating role of social support and nutrition knowledge
Authors: Zhang Qiang , Huangfu Chunrong , Wan Qingqing , Su Weiwei , Zhu Xiao , Yu Bin , Min Xiangdong , Liu Zhitao 
Published: May 2024

BackgroundAlthough social capital has been linked to dietary intake particularly in disadvantaged populations, little is known about the mechanisms. This study aimed to investigate whether social support (SS) and nutrition knowledge (NK) mediate the association between social capital and healthy eating habits.MethodsA probability sample of two ethnic minority groups in Yunnan Province, Southwest China were included (n = 1,033, mean age 47.5 ± 14.7 years). Bonding and bridging social capital (BOC and BRC) were assessed with the Personal Social Capital Scale (PSCS-16). Dietary data were evaluated with the Chinese Healthy Eating Index (CHEI), a measure of diet quality which reflects adherence to the Chinese Dietary Guidelines. NK and SS were measured with a validated questionnaire and scale, respectively. Structural Equation Modeling was used to calculate the direct, indirect and total effects of social capital on CHEI scores.ResultsThe mean score of CHEI was 57.4 ± 9.8, which was significantly lower in men and older people. Low adherence to dietary guidelines were to observed in the consumption of dairy, beans, nuts, animal-source food vegetables and fruits. BOC and BRC were positively associated with CHEI score (β = 0.37 and 0.38, all p &lt; 0.05). Social support and nutrition knowledge mediated 45.9 and 39.5% of the total effect of social capital on CHEI score, respectively.ConclusionSocial capital appears to enhance adherence to dietary guidelines by improving nutrition knowledge and social support. Nutrition promotion programs therefore should consider incorporating strategies that foster social capital development, particularly in disadvantaged populations.
LINC00958 as new diagnostic and prognostic biomarker of childhood acute lymphoblastic leukaemia of B cells
Authors: Altieri Filomena , Buono Lorena , Lanzilli Mariamichela , Mirabelli Peppino , Cianflone Alessandra , Beneduce Giuliana , De Matteo Antonia , Parasole Rosanna , Salvatore M. , Smaldone Giovanni 
Published: May 2024

BackgroundPaediatric acute B-cell lymphoblastic leukaemia is the most common cancer of the paediatric age. Although the advancement of scientific and technological knowledge has ensured a huge step forward in the management of this disease, there are 15%–20% cases of recurrence leading to serious complications for the patient and sometimes even death. It is therefore necessary to identify new and increasingly personalised biomarkers capable of predicting the degree of risk of B-ALL in order to allow the correct management of paediatric leukaemia patients.MethodsStarting from our previously published results, we validate the expression level of LINC00958 in a cohort of 33 B-ALL and 9 T-ALL childhood patients, using in-silico public datasets as support. Expression levels of LINC00958 in B-ALL patients stratified by risk (high risk vs. standard/medium risk) and who relapsed 3 years after the first leukaemia diagnosis were also evaluated.ResultsWe identified the lncRNA LINC00958 as a biomarker of B-ALL, capable of discriminating B-ALL from T-ALL and healthy subjects. Furthermore, we associated LINC00958 expression levels with the disease risk classification (high risk and standard risk). Finally, we show that LINC00958 can be used as a predictor of relapses in patients who are usually stratified as standard risk and thus not always targeted for marrow transplantation.ConclusionsOur results open the way to new diagnostic perspectives that can be directly used in clinical practice for a better management of B-ALL paediatric patients.
A systematic review and meta-analysis of Danshen combined with mesalazine for the treatment of ulcerative colitis
Authors: Zhang Wei , Xiong Peiyu , Liu Junyu , Hu Hengchang , Song Li , Liu Xinglong , Jia Bo 
Published: May 2024

Purpose: Current pharmacological treatments for Ulcerative Colitis (UC) have limitations. Therefore, it is important to elucidate any available alternative or complementary treatment, and Chinese herbal medicine shows the potential for such treatment. As a traditional Chinese herbal medicine, Danshen-related preparations have been reported to be beneficial for UC by improving coagulation function and inhibiting inflammatory responses. In spite of this, the credibility and safety of this practice are incomplete. Therefore, in order to investigate whether Danshen preparation (DSP) is effective and safe in the treatment of UC, we conducted a systematic review and meta-analysis.Methods: PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database and CQVIP Database were searched for this review.The main observation indexes were the effect of DSP combined with mesalazine or DSP on the effective rate, platelet count (PLT), mean platelet volume (MPV) and C-reactive protein (CRP) of UC. The Cochrane risk of bias tool was used to assess the risk of bias. The selected studies were evaluated for quality and data processing using RevMan5.4 and Stata17.0 software.Results: A total of 37 studies were included. Among them, 26 clinical trials with 2426 patients were included and 11 animal experimental studies involving 208 animals were included. Meta-analysis results showed that compared with mesalazine alone, combined use of DSP can clearly improve the clinical effective rate (RR 0.86%, 95% CI:0.83–0.88, p &lt; 0.00001) of UC. Furthermore it improved blood coagulation function by decreasing serum PLT and increasing MPV levels, and controlled inflammatory responses by reducing serum CRP, TNF-α, IL-6, and IL-8 levels in patients.Conclusion: Combining DSP with mesalazine for UC can enhance clinical efficacy. However, caution should be exercised in interpreting the results of this review due to its flaws, such as allocation concealment and uncertainty resulting from the blinding of the study.Systematic Review Registration: http://www.crd.york.ac.uk/PROSPERO/myprospero.php, identifier PROSPERO: CRD42022293287
High-gain lithium niobate brillouin laser with tunable phonon frequency of 1∼31 GHz
Authors: Liu Huibo , Yu Yu , Li Kai , Yu Hengzhe , Wu Di , Wang Yulei , Lu Zhiwei 
Published: May 2024

Stimulated Brillouin scattering (SBS) is a significant nonlinear optical phenomenon utilized across various fields. Its applications span optical sensing, microwave photonics, and all-optical signal processing. In the current information-driven era, the laser industry is imposing increasingly stringent demands on laser technologies, thus propelling integrable on-chip SBS devices into a pivotal research trajectory. Simultaneously, the quest for materials manifesting heightened SBS effects has emerged as a primary focal point in optical fiber transmission endeavors. Lithium niobate (LN) stands out as a promising nonlinear optical material endowed with numerous exemplary attributes. These encompass a high refractive index, fostering potent photon-phonon interactions, low loss characteristics, and high integration potential. Consequently, employing LN as a material for Brillouin lasers promises to enhance certain aspects of laser performance and enable more comprehensive research into Brillouin lasers. In this paper, a micro-ring waveguide structure with LN as the main material is constructed, and the forward gain of stimulated Brillouin scattering, the distribution of electric field in multiple modes and the maximum tunable range are further analyzed. The simulation results exhibit that the tunable forward SBS effect can be achieved in the LN optical waveguides, the maximum forward Brillouin gain can reach 1.34W−1 m−1. Additionally, the tunable phonon frequency can range from 1 GHz to 31 GHz, effectively doubling that of silicon ring waveguides and thus extending the range of phonon tunability. Therefore, the LN micro-ring waveguide structure provides a new reference direction for the construction of a new tunable laser and a new idea for the generation of lasers to find a Brillouin medium with high SBS effect.
Exogenous and endogenous antioxidants in osteoporosis risk: causal associations unveiled by Mendelian Randomization analysis
Authors: Li Yuancheng , Qi Huaqian , Huang Xin , Lu Gang , Pan Huashan 
Published: May 2024

BackgroundRecent epidemiological studies and animal experiments have highlighted the significant role of oxidative stress in the development of osteoporosis (OP). The provision of antioxidants is widely considered a fundamental strategy to combat free radical-induced stress, inhibit oxidative damage, and potentially reverse the adverse effects of oxidative stress on bone health. However, there is no consensus in the scientific literature regarding the practical effectiveness of antioxidants in OP prevention and treatment. Some studies have not shown a clear connection between antioxidant supplementation and decreased OP risk. Therefore, it is essential to clarify the potential causal relationship between antioxidants and the development of OP.MethodsThe study utilized the inverse variance weighted (IVW) approach as the primary analytical method in the Mendelian Randomization (MR) framework to investigate the causal effects of five exogenous and six endogenous antioxidants on the risk of OP. To thoroughly assess potential pleiotropic effects and heterogeneity among the data analyzed, the MR-Egger intercept test was employed, and Cochran’s Q statistic was calculated.ResultsIn the evaluation of exogenous antioxidants, single-directional two-sample MR analyses did not reveal any statistically significant relationship between these agents and the risk of OP. Regarding endogenous antioxidants, bidirectional two-sample MR analyses were conducted, which generally indicated that most genetically regulated endogenous antioxidants had no significant association with the onset risk of OP. A significant causal relationship was found between OP and serum albumin levels (β: −0.0552, 95%CI: −0.0879 to −0.0225, p< 0.0011 after Bonferroni adjustment, power = 100%).ConclusionThe research uncovers OP as a possible determinant contributing to a decrement in serum albumin levels, and further suggests a potentially intimate relationship between the downward trajectory of serum albumin concentrations and the advancement of the OP disease process.
Effects of sexual assault vs. other traumatic experiences on emotional and cannabis use outcomes in regular cannabis users with trauma histories: moderation by gender?
Authors: Stewart Sherry H. , Khoury Juliana M. B. , Watt Margo C. , Collins Pamela , DeGrace Sarah , Romero-Sanchiz Pablo 
Published: May 2024

IntroductionWhile sexual assault may have particularly adverse emotional effects compared with other forms of trauma, it remains unclear which emotional outcome dimensions are impacted, whether cannabis outcomes are similarly impacted, and whether gender differences exist in sexual assault’s links with these outcomes.MethodsN = 100 cannabis users with trauma histories (M age = 33.1) completed standardized measures of demographics, trauma exposure, posttraumatic stress (PTS) and depressive symptoms, hopelessness, and cannabis outcomes (frequency, medicinal prescription, motives, and craving).ResultsSexual assault was experienced more often by women (83.9%) than men (31.8%). A series of 2 × 2 analyses of variance [gender: women (n = 56) vs. men (n = 44) × trauma type: sexual assault (n = 61) vs. other (n = 39)] and logistic regression revealed that sexual assault survivors scored higher than other trauma survivors on re-experiencing and hyperarousal PTS symptoms (DSM-5 Clusters B and E), cognitive depressive symptoms, hopelessness, cannabis use frequency, medicinal cannabis prescription, cannabis use to cope with psychological symptoms, and compulsivity craving; and lower on social and enhancement cannabis use motives. In terms of gender main effects, women scored higher than men on cannabis use to cope with negative emotions. In terms of interactions for PTS Cluster D symptoms (negative alterations in mood/cognitions), among men only, sexual assault survivors scored higher than other trauma survivors; and for cannabis enhancement motives and purposefulness cannabis craving, among sexual assault survivors only, women scored higher than men.DiscussionAcross many different trauma, women survivors’ use of cannabis to cope with negative affect should be a specific therapeutic focus. Moreover, we identified specific emotional and cannabis use outcomes that should be of specific clinical concern among sexual assault survivors regardless of gender. Finally, in terms of gender differences of clinical interest among sexual assault survivors, while PTS Cluster D symptoms should be specific treatment targets in men, cannabis enhancement motives and purposefulness craving should be treatment targets in women.
Parenting children with disabilities in Sweden: a cluster-analysis of parenting stress and sufficiency of informal and formal support
Authors: Täljedal Torun , Granlund Mats , Osman Fatumo , Norén Selinus Eva , Fängström Karin 
Published: May 2024

ObjectiveTo investigate patterns of parenting stress and access to sufficient informal and formal support among parents of children with disabilities. To explore whether child cognitive level, conduct problems and the need of language interpretation in contacts between parents and professionals are associated with patterns of parenting stress and support.MethodParents (N = 140) of children with disabilities in Sweden completed a questionnaire about parenting stress and support. Patterns of three variables—parenting stress and access to sufficient informal and formal support—were investigated using cluster analysis. The relationship of child cognitive level, level of conduct problems and of language interpretation needs between parents and professionals to cluster membership was explored using multinomial logistic regression.ResultsFive different clusters of parenting stress and support emerged. Parents in cluster 1 had lower than sample mean ratings on all three variables. Cluster 2 had elevated parenting stress, cluster 3 had elevated insufficient informal support and cluster 4 had elevated insufficient formal support. Cluster 5 had elevated ratings on all three variables. Greater child cognitive difficulties increased the likelihood of parent membership in cluster 2 (elevated stress), cluster 3 (elevated insufficient informal support), or cluster 5 (elevated ratings on all variables). Child conduct problems increased the likelihood of membership in cluster 2 (elevated stress) or cluster 5 (elevated ratings on all variables). No relationship between language interpretation needs and cluster membership was found.ConclusionsPatterns of parenting stress and sufficiency of support, and their associations with child characteristics, vary substantially. However, families of children with conduct problems experiencing elevated parenting stress in combination with insufficient informal and formal support, may be particularly vulnerable. The results of the current study highlight the clinical importance of exploring and identifying individual parenting stressors and perceived levels of support, to be able to adapt services to better suit a variety of needs, and thus promote equitable care.
Causal associations between chronic viral hepatitis and psychiatric disorders: a Mendelian randomization study
Authors: Fu Haoshuang , Jiang Shaowen , Song Shuying , Zhang Chenxi , Xie Qing 
Published: May 2024

BackgroundThere may be an interaction between viral hepatitis and psychiatric disorders during disease progression. Herein, we conducted Mendelian randomization (MR) to explore the causal associations and mediators between viral hepatitis and psychiatric disorders.MethodsGenome-wide association studies summary data for viral hepatitis [including chronic hepatitis B (CHB) and chronic hepatitis C (CHC)] and psychiatric disorders (including depression, anxiety, schizophrenia, obsessive-compulsive disorder, bipolar disorder, and post-traumatic stress disorder) were obtained. Two-sample MR was performed to assess the causal associations between viral hepatitis and psychiatric disorders. Further, a mediation analysis was conducted to evaluate the potential mediators. Inverse-variance weighted, MR-Egger, and weighted median were used as the main methods, while a sensitivity analysis was performed to evaluate pleiotropy and heterogeneity.ResultsThere was no causal effect of CHB/CHC on psychiatric disorders, as well as psychiatric disorders on CHB. However, schizophrenia presented a causal effect on increased CHC risk [odds ratio (OR)=1.378, 95%CI: 1.012–1.876]. Further, a mediation analysis identified coffee consumption and body mass index as mediators in the effect of schizophrenia on CHC, mediating 3.75% (95%CI: 0.76%–7.04%) and 0.94% (95%CI: 0.00%–1.70%) proportion, respectively.ConclusionWe revealed that schizophrenia patients faced a high risk of CHC, and insufficient coffee consumption and underweight could mediate the causal effect of schizophrenia on CHC. The prevention of hepatitis C might be a beneficial strategy for patients with schizophrenia. The right amount of nutrition supplements and coffee consumption might be part of a beneficial lifestyle in preventing the high CHC risk in patients with schizophrenia.
Cadmium accumulation and transfer in yellowish-brown and limestone soils of five potato varieties based on a pot experiment in the central Hanjiang River basin
Authors: Qi Xin , Luo Kai , Li Yuqi , Zhang Yi , Fang Yuan , Yang Meiling 
Published: May 2024

IntroductionThe contamination of farmland soil with the heavy metal cadmium (Cd) has consistently been a globally recognized environmental issue, especially with the rapid development of the central part of the Hanjiang River basin. The Cd contamination has become increasingly serious, and the accumulation and translocation of Cd in the soil-crop system warrant further research.MethodsIn this study, representative yellowish-brown soil and limestone soil from Hubei Province in China, as well as five varieties of potato (Solanum tuberosum L), were selected to investigate Cd accumulation and transfer regulation from soil to plants using pot tests at varying Cd concentration levels.Results and discussionFor Eshu-12, Favorita, Huashu-6, Mira, and Zhongshu-5, the accumulation capacity of Cd in different parts exhibits a consistent pattern: Cdroot &gt; Cdstem &gt; Cdleaf &gt; Cdtuber. The potato varieties exhibited distinct differences in Cd concentration, as follows: CdFavorita &gt; CdMira &gt; CdEshu-12 &gt; CdHuashu-6 &gt; CdZhongshu-5. The yellowish-brown soil demonstrated a higher accumulation and lower transport capacity to the plants of Cd, while limestone soil exhibited the opposite trend. The bio-concentration factor and transfer coefficients in yellowish-brown soil revealed significant (p &lt; 0.05) accumulation and transformation of Cd in potatoes.Conclusion and recommendationsThis significant accumulation of Cd posed a higher risk of transfer through the food chain. Therefore, in the Hanjiang River basin, where Cd contamination is a concern, the cultivation of potatoes in limestone soil is more advisable than yellowish-brown soil to mitigate food safety risks.
KEBENARAN PERSPEKTIF FILSAFAT ILMU SEBAGAI LANDASAN DALAM BERKARYA ILMIAH
Authors: - Agus Salam 
Published: May 2024

Mencintai kebenaran merupakan sifat hakiki manusia sebagai pengemban amanah penemu, pengembang, penjelas, serta penyampai nilai nilai kebenaran. Kebenaran merupakan nilai utama dalam kehidupan manusia, dimana martabat kemanusiaannya akan terjamin kemartabatannya takkala nilai kebenaran dipegang teguh. Manusia merupakan mahluk yang setiap saat mencari kebenaran karena jika manusia mengerti dan memahami kebenaran, maka sifat asasinya terdorong pula untuk melaksanakan kebenaran itu. Jika tidak demikian, manusia akan mengalami pertentangan batin, konflik spikologis.
Kebenaran perspektif filsafat ilmu oleh ilmuan memiliki tafsiran beragam sehingga tidak setiap ilmuan memiliki pandangan yang tepat sama dengan ilmuan lainnya, namun hal ini bukanlah suatu problematika karena justru dari perbedaan pendapat akan memberikan peluang untuk memajukan garis depan daerah ketahuan jauh kedalam daerah ketidak tahuannya, tulisan ini diharapkan dapat menjadi landasan awal dalam melahirkan karya yang selalu menjunjung tinggi nilai kebenaran karena tidak ada jalan lain menuju pemuasan batin kecuali bersamanya.
Diawal dibahas mendalam tentang hakekat manusia dan kebenaran diikuti dengan pembahasan tentang berilmu beramal ilmiah ciri manusia berpikir benar, yang merinci persoalan berpikir logis dengan mencitai kebenaran, ketahuilah dengan sadar yang dikerjakan, ketahuilah dengan sadar yang dikatakan, need distingsi dan klasifikasi semestinya, mencintailah ketepatan definisi mengetahui denga sadar kenapa menyimpulkan, hindari kesalahan dengan segenap jiwa, dilanjutkan dengan konsep kebenaran, tingakatan kebenaran dan unsur kebenaran diakhiri dengan sandaran filosof kepada 3 cara untuk menguji kebenaran, yaitu koresponden, teori koherensi atau konsistensi, dan teori pragmatis.
Kata Kunci: Kebenaran,Filsafat Ilmu,Karya Ilmiah