bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Bedtime Very Low Dose Cyclobenzaprine on Symptoms and Sleep Physiology in Patients with Fibromyalgia Syndrome: A Double-blind Randomized Placebo-controlled Study
Authors: MOLDOFSKY HARVEY , HARRIS HERBERT W. , ARCHAMBAULT W. TAD , KWONG TERENCE , LEDERMAN SETH 
Published: September 2011

Objective.To determine the effects of bedtime very low dose (VLD) cyclobenzaprine (CBP) on symptoms and sleep physiology of patients with fibromyalgia (FM), unrefreshing sleep, and the α-nonREM sleep electroencephalographic (EEG) anomaly at screening.Methods.Of 37 patients with FM in the screened population, 36 were randomized and treated in this 8-week, double-blind, placebo-controlled, dose-escalating study of VLD CBP 1–4 mg at bedtime. We evaluated changes in subjective symptoms including pain, tenderness, fatigue, mood [Hospital Anxiety and Depression Scale (HAD)], and objective EEG sleep physiology (at screening, baseline, and Weeks 2, 4, and 8).Results.In the VLD CBP-treated group (n = 18) over 8 weeks, musculoskeletal pain and fatigue decreased, tenderness improved; total HAD score and the HAD depression subscore decreased; patient-rated and clinician-rated fatigue improved. In the placebo-treated group (n = 18), none of these outcome measures changed significantly. Compared to placebo at 8 weeks, VLD CBP significantly improved pain, tenderness, and the HAD Depression subscore. Analysis of cyclic alternating pattern (CAP) sleep EEG revealed that significantly more subjects in the VLD CBP group than the placebo group had increased nights of restorative sleep in which CAPA2+A3/CAPA1+A2+A3= CAPA2+A3(Norm)≤ 33%. For VLD CBP-treated subjects, the increase in nights with CAPA2+A3(Norm)≤ 33% was correlated to improvements in fatigue, total HAD score, and HAD depression score.Conclusion.Bedtime VLD CBP treatment improved core FM symptoms. Nights with CAPA2+A3(Norm)≤ 33% may provide a biomarker for assessing treatment effects on nonrestorative sleep and associated fatigue and mood symptoms in persons with FM.
Emerging Issues in Pharmacological Management of Rheumatoid Arthritis: Results of a National Needs Assessment Survey Identifying Practice Variations for the Development of Canadian Rheumatology Association Clinical Practice Recommendations: Table 1.
Authors: BYKERK VIVIAN P. , SCHIEIR ORIT , AKHAVAN POONEH , HAZLEWOOD GLEN S. , CHENG CARLY K. , BOMBARDIER CLAIRE 
Published: September 2011

Objective.To describe Canadian clinical practice patterns in the pharmacological management of rheumatoid arthritis (RA) and identify practice variations.Methods.A 44-item pre-guideline needs assessment survey was sent to all members of the Canadian Rheumatology Association (CRA). Descriptive statistics were used to summarize respondent characteristics and practice patterns.Results.Survey respondents (n = 164) reported variations in practice regarding assessment strategies, treatment with disease-modifying antirheumatic drug monotherapy versus combination therapy, methotrexate dosing and escalation, corticosteroid strategies, and optimal use of biologics.Conclusions.Practice variations identified in this pre-guideline needs assessment survey were used to formulate key treatment questions for the development of CRA recommendations.
Resistin Levels in Lupus and Associations with Disease-specific Measures, Insulin Resistance, and Coronary Calcification
Authors: BAKER JOSHUA F. , MORALES MEGAN , QATANANI MOHAMMED , CUCCHIARA ANDREW , NACKOS ELENI , LAZAR MITCHELL A. , TEFF KAREN , VON FELDT JOAN MARIE 
Published: September 2011

Objective.To evaluate levels of resistin in female subjects with systemic lupus erythematosus (SLE) compared to age and race-matched controls and to determine the relationship between resistin and systemic inflammation, disease measures, and coronary artery calcification (CAC).Methods.Resistin levels were measured on stored samples from 159 women with SLE and 70 controls as an extension of a previous cross-sectional study. Spearman correlations and multivariable regressions were used to examine whether resistin levels were associated with SLE, disease-specific and inflammatory markers, insulin resistance, and CAC.Results.In a multivariable linear regression model, a diagnosis of SLE was significantly associated with higher resistin levels independent of age, race, renal function, body mass index (BMI), high-sensitivity CRP (hsCRP), hypertension, diabetes, and steroid use. In SLE, resistin levels correlated positively with Systemic Lupus International Collaborating Clinics Damage Index, glomerular filtration rate (GFR), hsCRP, erythrocyte sedimentation rate, homocysteine, and disease duration (all p < 0.03). Resistin level did not correlate with markers of insulin resistance or body adiposity, including homeostatic model assessment or BMI. Resistin levels were significantly elevated in SLE cases with CAC compared to cases without CAC (16.58 vs 13.10 ng/ml, respectively; p = 0.04). In multivariate logistic regression, the association was not present after adjustment for age, race, and GFR.Conclusion.SLE was independently associated with higher resistin levels. Among subjects with SLE, higher resistin level correlated positively with renal dysfunction, inflammatory markers, and disease damage but not with insulin resistance or BMI. SLE cases with CAC had higher resistin levels than cases without CAC; however, this relationship was dependent on other established risk factors.
Adalimumab or Cyclosporine as Monotherapy and in Combination in Severe Psoriatic Arthritis: Results from a Prospective 12-month Nonrandomized Unblinded Clinical Trial
Authors: KARANIKOLAS GEORGE N. , KOUKLI EFTYHIA-MARIA , KATSALIRA AIKATERINI , ARIDA AIKATERINI , PETROU DIMITRIOS , KOMNINOU ELENI , FRAGIADAKI KALLIOPI , ZACHARIOUDAKI ANNA , LASITHIOTAKIS IOANNIS , GIAVRI EIRINI , VAIOPOULOS GEORGE , SFIKAKIS PETROS P. 
Published: September 2011

Objective.To assess the efficacy and safety of adalimumab or cyclosporine (CYC) as monotherapy or combination therapy for patients with active psoriatic arthritis (PsA), despite methotrexate (MTX) therapy.Methods.A prospective 12-month, nonrandomized, unblinded clinical trial of 57, 58, and 55 patients who received CYC (2.5–3.75 mg/kg/day), adalimumab (40 mg every other week), or combination, respectively. Lowering of concomitant nonsteroidal antiinflammatory drugs (NSAID) and corticosteroids and reductions of adalimumab and/or CYC doses in responding patients were not restricted.Results.Mean numbers of tender/swollen joints at baseline were 9.7/6.7 in CYC-treated, 13.0/7.8 in adalimumab-treated, and 14.5/9.4 in combination-treated patients, indicating lesser disease severity of patients assigned to the first group. The Psoriatic Arthritis Response Criteria at 12 months were met by 65% of CYC-treated (p = 0.0003 in favor of combination treatment), 85% of adalimumab-treated (p = 0.15 vs combination treatment), and 95% of combination-treated patients, while the American College of Rheumatology-50 response rates were 36%, 69%, and 87%, respectively (p < 0.0001 and p = 0.03 in favor of combination treatment). A significantly greater mean improvement in Health Assessment Questionnaire Disability Index was achieved by combination treatment (−1.11) vs CYC (−0.41) or adalimumab alone (−0.85). Combination therapy significantly improved Psoriasis Area and Severity Index-50 response rates beyond adalimumab, but not beyond the effect of CYC monotherapy. Doses of NSAID and corticosteroids were reduced in combination-treated patients; CYC doses and frequency of adalimumab injections were also reduced in 51% and 10% of them, respectively. No new safety signals were observed.Conclusion.The combination of adalimumab and CYC is safe and seemed to produce major improvement in both clinical and serological variables in patients with severely active PsA and inadequate response to MTX.
Levels of Serum Matrix Metalloproteinase-3 Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis
Authors: VISWANATH VISHAD , MYLES ARPITA , DAYAL RAJESHWAR , AGGARWAL AMITA 
Published: September 2011

Objective.Serum matrix metalloproteinase-3 (MMP-3) has been shown to reflect disease activity in ankylosing spondylitis (AS) and rheumatoid arthritis. Elevated levels have been found in juvenile idiopathic arthritis (JIA). In the enthesitis-related arthritis category of JIA (JIA-ERA), we studied whether serum MMP-3 levels and ratios of MMP-3/tissue inhibitor of metalloproteinase (TIMP-1) are correlated with disease activity and whether they are sensitive to change in disease activity.Methods.A total of 54 patients with JIA-ERA (International League of Associations for Rheumatology criteria) were enrolled for study. Baseline disease activity measures included tender and swollen joint counts, Maastricht AS Enthesitis Score, Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI), patient assessment of pain and global disease activity, physician assessment of global disease activity, and erythrocyte sedimentation rate (ESR). Serum MMP-3 and TIMP-1 levels were measured using ELISA. A group of 24 patients were followed up for longitudinal study.Results.The mean age of 54 patients (48 males) at disease onset was 11.8 ± 4.19 years and duration of disease was 5.2 ± 4.3 years. Median ESR was 65 mm/h (range 46.5–97) and median BASDAI was 3.4 (range 2.5–4.7). Median MMP-3, TIMP-1, and MMP-3/TIMP-1 ratio were 50.4 ng/ml (IQR 13.0–193.8), 228.9 ng/ml (IQR 108.2–290.4), and 0.3 (IQR 0.07–1.13), respectively. At inclusion MMP-3 levels correlated directly with various disease activity measures: tender joint count (TJC; r = 0.60), swollen joint count (SJC; r = 0.45), BASFI (r = 0.29), BASDAI (r = 0.32), ESR (r = 0.49), physician global assessment (r = 0.40), patient visual analog scale for pain (r = 0.28), and patient global assessment (r = 0.38; all p < 0.05). MMP-3/TIMP-1 ratio correlated only with TJC (r = 0.51), SJC (r = 0.39), and ESR (r = 0.34; p < 0.05). At followup, change in MMP-3 correlated with changes in TJC (r = 0.42) and SJC (r = 0.44; p < 0.05), while change in ESR did not correlate with change in any disease activity measure.Conclusion.MMP-3 levels are a good marker for disease activity in JIA-ERA.
FCRL3 –169C/C Genotype Is Associated with Anti-citrullinated Protein Antibody-positive Rheumatoid Arthritis and with Radiographic Progression
Authors: MAEHLEN MARTHE T. , NORDANG GRY B. , SYVERSEN SILJE W. , van der HEIJDE DÉSIRÉE M. , KVIEN TORE K. , UHLIG TILL , LIE BENEDICTE A. 
Published: September 2011

Objective.Studies of Caucasian populations have shown conflicting results concerning the association between a promoter polymorphism –169T>C of the Fc receptor-like 3 (FCRL3) gene and rheumatoid arthritis (RA). It is unknown whether FCRL3 is associated with autoantibody status and disease severity. We investigated associations between FCRL3 –169T>C and autoantibody status and joint damage in patients with RA.Methods.A total of 652 Norwegian patients with RA from 2 cohorts and 981 Norwegian controls, previously genotyped for FCRL3 –169T>C (rs7528684), were studied. Data on anticitrullinated protein antibodies (ACPA) and rheumatoid factor (RF) were available. The EURIDISS cohort (disease duration ≤ 4 yrs at baseline) was followed longitudinally, with assessment of radiographic hand damage at baseline and after 10 years (n = 117) according to the van der Heijde-modified Sharp score.Results.We found significant associations with ACPA-positive RA for both the C allele (OR 1.28, 95% CI 1.08–1.52, p = 0.004) and the C/C genotype (OR 1.57, 95% CI 1.18–2.10, p = 0.002). Similar associations were seen with RF-positive RA. No association was found with ACPA-negative or RF-negative RA. The C/C genotype was found to be associated with 10-year radiographic progression in multivariate linear and logistic regression analyses, after adjustment for ACPA, erythrocyte sedimentation rate, age, and sex.Conclusion.The promoter polymorphism of FCRL3 was associated with autoantibody-positive RA. Despite the low number of patients, the C/C genotype of the FCRL3 polymorphism consistently and independently predicted radiographic progression. These findings suggest that FCRL3 is involved in both disease susceptibility and progression.
Minimally Important Difference of Health Assessment Questionnaire in Psoriatic Arthritis: Relating Thresholds of Improvement in Functional Ability to Patient-rated Importance and Satisfaction
Authors: MEASE PHILIP J. , WOOLLEY J. MICHAEL , BITMAN BOJENA , WANG BRIAN C. , GLOBE DENISE R. , SINGH AMITABH 
Published: September 2011

Objective.To evaluate changes in function as measured by Health Assessment Questionnaire Disability Index (HAQ-DI) and the meaningfulness of the changes, in importance and satisfaction, in patients with psoriatic arthritis (PsA).Methods.HAQ-DI was assessed at baseline and at Weeks 4, 12, and 24 in a randomized double-blind study of 205 patients with active PsA receiving etanercept 25 mg twice weekly or placebo. Concurrently, patients rated the importance of and satisfaction with their change in function on a 7-point scale (1 = not at all important/satisfied; 7 = extremely important/satisfied). Mean HAQ-DI improvement corresponding to ratings of minimally (2–3) or very (6–7) important or satisfied was determined using a posthoc linear mixed-model analysis. Patient importance ratings were used as an anchor to estimate minimally important difference (MID) for HAQ-DI; distribution-based estimates were also calculated.Results.A total of 161 patients (69 placebo; 92 etanercept) had ≥ 1 HAQ-DI scores showing improvement from baseline and a corresponding importance or satisfaction rating. HAQ-DI improvements corresponding to importance scale ratings of 2 or 3 were 0.335 (95% CI 0.214, 0.455) and 0.360 (95% CI 0.263, 0.456), respectively, suggesting an MID of about 0.35. HAQ-DI improvements corresponding to satisfaction scale ratings of 2 and 3 were 0.293 (95% CI 0.230, 0.357) and 0.360 (95% CI 0.307, 0.413). For a given change in HAQ-DI, nearly two-thirds of patients indicated a lower rating for satisfaction than for importance. This trial was registered in the ClinicalTrials.gov registry (NCT00317499).Conclusion.Our study suggests the MID for HAQ-DI in PsA is about 0.35. The results may also provide insight into patient satisfaction with changes in function and expectations for therapy.
The Association of LRP5 Gene Polymorphisms with Ankylosing Spondylitis in a Chinese Han Population
Authors: LIU JIANMIN , ZHOU XIAOYAN , SHAN ZHENXING , YANG JIGUO , YANG QINGRUI , CUI YAZHOU , HAN JINXIANG 
Published: September 2011

Objective.To clarify the association between polymorphisms of low-density lipoprotein receptor-related protein 5 (LRP5) with ankylosing spondylitis (AS) in a Chinese Han population.Methods.Sixteen patients with AS were recruited for preliminary screening through gene sequencing. Then 14 single-nucleotide polymorphisms (SNP) of LRP5 were followed up in 296 patients and 170 controls.Results.Sequencing the LRP5 showed 24 SNP including 3 novel SNP [LRP5SNP1 (c.-1596T > C), LRP5SNP2 (c.3764-30G > A), and LRP5SNP3 (c.4488+74G > A)]. Validation of SNP showed that the LRP5SNP3 were associated with AS after multiple testing correction (allele Pc = 0.0087, genotype Pc = 0.0316, haplotype AGA, Pc = 0.0051, OR = 2.54 and haplotype AGG, Pc = 0.048, OR = 0.63, respectively). The SNP rs686921 was associated with male predominance in both patients with AS (p = 0.032, OR 1.54) and controls (p = 0.014, OR 1.94).Conclusion.LRP5 may be involved in the pathogenesis of AS. Further study will be required to clarify the effect of LRP5 on the pathogenic mechanism of AS.
Du côté du musée de l'Homme : nouvelles approches de la Résistance pionnière en zone occupée
Authors: Blanc Julien 
Published: September 2011

Le « réseau du musée de l’Homme », organisation emblématique des débuts de la Résistance en zone occupée, semble bien connu. Une étude précise permet pourtant de souligner la richesse de ses composantes, la variété de ses activités ou encore l’originalité de son fonctionnement, loin de l’image d’Épinal qui s’est imposée. À travers le cas d’école du musée de l’Homme, ce sont quelques-unes des spécificités de cette première désobéissance qui sont ici mises en lu-mière.
« La coutume de la prévôté de Caen »
Authors: Jean-Marie Laurence 
Published: September 2011

Cette édition de sources livre trois versions successives de la « la coutume de la prévôté de Caen » (consuetudo in prefectura Cadomi). Le texte latin, connu par trois copies de la fin du XIII e ou du début du XIV e siècle, pourrait être antérieur d’au moins un siècle. Une version en français, probablement attribuable au deuxième tiers du XIV e siècle et un texte moderne, imprimé en 1595, sont connus par des copies du XIX e siècle. Malgré les différences entre les trois versions, les permanences justifient l’association des trois textes dans la présente édition. Surtout, ce sont des sources riches et non de simples listes de produits et de taxes y afférent. Les informations fournies dépassent l’histoire proprement économique. Ces textes prennent en compte entrée, sortie et transit des marchandises. C’est la ville mais aussi l’espace qui en dépend, banlieue et ressort de la prévôté, qui sont ainsi mis en avant. La désignation des catégories de populations et des exemptions peut fournir des enseignements en matière d’histoire sociale et politique. Transports par terre, mer et fleuve sont évoqués de même que les lieux de commerce dans la ville et les temps de l’échange. Les denrées et marchandises sont soigneusement énumérées et quantifiées, en ce sens ces textes ont un intérêt linguistique évident. Bien qu’il s’agisse de textes normatifs, ces documents peuvent contribuer à l’étude des productions et des échanges économiques.
Le libéralisme comme recherche de la justice
Authors: Inoue Tatsuo 
Published: September 2011

Résumé Qu’a été le libéralisme ? Qu’est-il maintenant ? Que doit-il devenir ? L’objectif de cet article est de présenter une clé pour répondre à ces questions. Après avoir montré la crise du libéralisme contemporain dans mon préambule, j’indique le sens pratique du libéralisme en tant que pensée qui remédie aux problèmes réels rencontrés actuellement par le Japon, l’Asie, le monde. Le libéralisme a en soi la puissance réformatrice critique pour lutter contre la réalité des oppressions et des discriminations bien enracinées dans le monde contemporain, mais les courants de pensée contemporains occidentaux la font se corroder. Par une critique radicale, en discernant exactement les faces positives et négatives inclues dans les deux héritages des Lumières et de la tolérance à l’origine du libéralisme, pour surmonter les faces négatives des deux et combiner leurs deux faces positives, j’explicite le sens de la justice universelle et refonde le libéralisme pour ouvrir la voie d’un renouveau du libéralisme en tant que pensée réformatrice critique.
L'autopoïèse et l'« individu » en train de se faire
Authors: Kawamoto Hideo 
Published: September 2011

Résumé La notion d’autopoïèse, proposée par Humbert R. Maturana et Francisco J. Varela, comme processus par lequel le vivant se produit lui-même a ses racines dans la Critique de la faculté de juger de Kant. Mais il convient d’en préciser la nature en introduisant la notion clé de « double opération » et en insistant sur les rapports de l’autopoïèse avec l’environnement.
Vers la profondeur du sensible : La Phénoménologie de l'esprit de Hegel et la compassion du bouddhisme du Grand Véhicule
Authors: Ryôsuke Ôhashi 
Published: September 2011

Résumé Dans toutes les étapes de la Phénoménologie de l’esprit , la sensibilité ( die Sinnlichkeit) est répétée comme « moment », et le sensible (das Sinnliche) est un « élément » qui constitue le cheminement total du processus du phénomène de l’« esprit ». La première est une fonction logique du mouvement ayant une structure « déductive ». Le second est la matière originale et le lieu lorsque ce mouvement prend ici de multiples formes. Cette distinction a pour effet de changer la compréhension traditionnelle du sens commun. Le sens commun non commun, c’est le sens commun dans la communauté contenant l’Étrangeté absolue. Dans l’étape de la religion de la Phénoménologie de l’esprit , nous pouvons lire ce sens commun non commun comme s’approfondissant dans le pathos commun (sympathie) non commun qui comporte à la fois la passion et la volonté. On peut affirmer que le pathos entre Dieu comme sentiment de Sa mort et l’homme est philosophiquement lié à la compassion dont parle le bouddhisme du Grand Véhicule.
Bonne fouille ne saurait mentir ?
Authors: Besson Claire , Chaoui-Derieux Dorothée , Desachy Bruno 
Published: September 2011

Peut-on prétendre faire de l’archéologie et mentir ? Comment peuvent se trouver associées cette discipline et cette posture, l’une visant la mise au jour d’éléments qu’il faudra interpréter le plus objectivement possible en s’entourant de garanties scientifiques, l’autre visant à la falsification et à la dissimulation ? Parmi les motivations qui poussent à fausser un discours scientifique, outre la quête de reconnaissance, deux exemples permettent de saisir les relations entre archéologie et mensonge : le « besoin de merveilleux » de la para-archéologie, et la récupération géopolitique. Ou comment l’archéologie, sans cesse en cours d’élaboration, voit utiliser cette précarité à son corps défendant et contribue à forger des mensonges sous couvert de scientificité.
Comment le rustique vint au village
Authors: Mihâilescu Vintilâ 
Published: September 2011

Dans une société encore rurale et agricole comme la Roumanie, l’aménagement de la maisnie reste un indicateur important des transformations structurales de la société. Après la chute du communisme, et surtout après l’instauration de la libre circulation européenne, les campagnes roumaines ont ainsi commencé à être peuplées de « maisons d’orgueil » qui clamaient une émancipation des paysans et une rupture ostentatoire avec le passé et le local. Du même coup, le travail paysan était chassé de l’espace domestique. Récemment, une nouvelle vague « rustique » s’est installée, envisageant un ré-ancrage fantasmé dans l’esprit du lieu. L’article poursuit ce processus complexe de domestication de la modernité et ses enjeux, de l’ostentation et du simulacrum à la reconnaissance sociale et à la quête de l’authenticité.
Construire l’avenir
Authors: Laszczkowski Mateusz 
Published: September 2011

Les nouvelles constructions d’Astana, la capitale du Kazakhstan, relèvent d’un projet tout à la fois symbolique et politique. L’auteur suggère que le matériel et l’imaginaire sont fusionnés à Astana afin de créer une « hétérotopie », au sens foucaldien du terme, un site distinct de la réalité prosaïque du Kazakhstan contemporain. Ce nouvel espace attire des migrants des quatre coins du pays en leur faisant miroiter une vision d’un futur personnel plus riant. Ces constructions présentent aux citoyens une mise en scène de l’État en tant que cadre de sociabilité viable, tandis que leur temporalité immobilise dans les limbes les relations de pouvoir.