bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global research trends in regulating gut microbiome to improve type 2 diabetes mellitus: bibliometrics and visual analysis
Authors: Jiang Rongsheng , Cong Zhengri , Zheng Likun , Zhang Long , Guan Qifan , Wang Sixian , Fang Jinxu , Chen Jiahao , Liu Mingjun 
Published: June 2024

BackgroundGut microbiome (GM) and type 2 diabetes mellitus (T2DM) have two-way effects. Improving T2DM by modulating GM in various ways, such as diet, exercise, and medication, is gradually becoming popular, and related studies have yielded positive results. However, there is still a lack of high-quality bibliometric analyses of research in this area. This study aims to systematize and comprehensively summarize the knowledge structure, research tropics, and research trends of GM and T2DM through bibliometric analysis.MethodsPublications related to GM and T2DM before January 9, 2024, in the Web of Science Core Collection (WOSCC) were searched in this study. Microsoft Excel 2019 was used to analyze publishing trends and CiteSpace (v.6.1.R6 Advanced) was used to analyze institutions, cited journals, references, and keywords.SCImago Graphica (v.1.0.39) was used to analyze countries/regions, institutions’ collaborations, cited authors, and published journals.ResultsWe finally included 1004 articles published from 2008 to 2023. The number of published articles showed an upward trend and reached its peak in 2022. China is the country with the largest number of articles, Univ Copenhagen is the institution with the largest number of articles, Fukui, Michiaki, Hamaguchi, Masahide are the scholars with the largest number of articles, and Cani and Patrice D. are the scholars with the largest number of citations. NUTRIENTS(Q1/5.9) published the most publications, while Nature (Q1/64.8; Cited 804 times) is the most frequently cited journal. Gut microbiota, Obesity, and insulin resistance are the most frequently used keywords. This study found that current researches focus on the effects of diet, exercise, and pharmacological modification of GM to improve T2DM and explores specific mechanisms. Future researches will focus on three areas: complications of T2DM and specific physiological processes, methods and measures to regulate GM, and new experimental techniques and assays.ConclusionThe current researches confirmed the effects and specific mechanisms of modulating GM to improve T2DM. Further exploration of the effects of modulating GM on T2DM complications and specific physiologic processes is a future trend of research. Exploring specific methods for regulating GM and developing new experimental techniques and assays are important for future research.
Transcriptional and functional remodeling of lung-resident T cells and macrophages by Simian varicella virus infection
Authors: Doratt Brianna M. , Malherbe Delphine C. , Messaoudi Ilhem 
Published: June 2024

IntroductionVaricella zoster virus (VZV) causes varicella and can reactivate as herpes zoster, and both diseases present a significant burden worldwide. However, the mechanisms by which VZV establishes latency in the sensory ganglia and disseminates to these sites remain unclear.MethodsWe combined a single-cell sequencing approach and a well-established rhesus macaque experimental model using Simian varicella virus (SVV), which recapitulates the VZV infection in humans, to define the acute immune response to SVV in the lung as well as compare the transcriptome of infected and bystander lung-resident T cells and macrophages.Results and discussionOur analysis showed a decrease in the frequency of alveolar macrophages concomitant with an increase in that of infiltrating macrophages expressing antiviral genes as well as proliferating T cells, effector CD8 T cells, and T cells expressing granzyme A (GZMA) shortly after infection. Moreover, infected T cells harbored higher numbers of viral transcripts compared to infected macrophages. Furthermore, genes associated with cellular metabolism (glycolysis and oxidative phosphorylation) showed differential expression in infected cells, suggesting adaptations to support viral replication. Overall, these data suggest that SVV infection remodels the transcriptome of bystander and infected lung-resident T cells and macrophages.
Quality of life and mental health status of glaucoma patients
Authors: Kopilaš Vanja , Kopilaš Mirko 
Published: June 2024

IntroductionGlaucoma, a leading cause of irreversible blindness worldwide, poses significant challenges to patients’ quality of life (QOL) and mental well-being.MethodsThis study aimed to investigate the complex interplay between clinical, demographic, and psychological factors and their impact on QOL among patients diagnosed with glaucoma. A cohort of 201 glaucoma patients, with a mean age of 70 years, participated in the study.ResultsDescriptive analyses revealed that participants reported living with a glaucoma diagnosis for an average of 13.38 years, highlighting the chronic nature of the disease in the cohort. Comorbidity was shown to be in close relationship with QOL, where with additional health problems have lower QOL scores (M = 34.86, SD = 18.25), as well as higher levels of anxiety (M = 10.64, SD = 5.38) and depression (M = 13.42, SD = 7.37). Correlation analyses further unveiled robust associations between clinical characteristics and psychological outcomes, with lower visual acuity strongly correlated with reduced QOL (rR = −0.74, pR &lt; 0.001; rL = −0.78, pL &lt; 0.001) and higher levels of anxiety and depression. Additionally, longer duration of glaucoma diagnosis was moderately associated with poorer QOL (r = 0.56, p &lt; 0.001) and increased psychological distress, highlighting the cumulative burden of living with the disease over time. Mediation analyses indicated that duration of diagnosis partially mediated the relationship between depression and QOL, as well as anxiety and QOL, suggesting that the prolonged experience of living with glaucoma may exacerbate the impact of psychological distress on QOL.DiscussionThese findings underscore the importance of holistic patient care approaches that address both the physical and psychological aspects of glaucoma to improve patient outcomes and enhance overall well-being.
The pan-plastome of Prunus mume: insights into Prunus diversity, phylogeny, and domestication history
Authors: Wang Jie , Kan Junhu , Wang Jie , Yan Xinlin , Li Yi , Soe Thida , Tembrock Luke R. , Xing Guoming , Li Sen , Wu Zhiqiang , Jia Minlong 
Published: June 2024

BackgroundsPrunus mume in the Rosaceae and commonly referred to as mei or Chinese plum is widely used as a traditional ornamental flowering plant and fruit tree in China. Although some population and genetic analyses have been conducted for this species, no extensive comparisons of genetic variation from plastomes have yet been investigated.MethodsWe de novo assembled a total of 322 complete P. mume plastomes in this study and did a series of comparative analyses to better resolve pan-plastomic patterns of P. mume. To determine the phylogeny and domestication history of this species, we reconstructed the phylogenetic tree of Prunus genus, and resolved the population structure of P. mume. We also examined the nucleotide variation of P. mume to find potential DNA barcodes.ResultsThe assembled plastomes exhibited a typical quadripartite structure and ranged from 157,871 bp to 158,213 bp in total size with a GC content ranging from 36.73 to 36.75%. A total of 112 unique genes were identified. Single nucleotide variants (SNVs) were the most common variants found among the plastomes, followed by nucleotide insertions/deletions (InDels), and block substitutions with the intergenic spacer (IGS) regions containing the greatest number of variants. From the pan-plastome data six well-supported genetic clusters were resolved using multiple different population structure analyses. The different cultivars were unevenly distributed among multiple clades. We also reconstructed a phylogeny for multiple species of Prunus to better understand genus level diversity and history from which a complex introgressive relationship between mei and other apricots/plums was resolved.ConclusionThis study constructed the pan-plastome of P. mume, which indicated the domestication of P. mume involved multiple genetic origins and possible matrilineal introgression from other species. The phylogenetic analysis in Prunus and the population structure of P. mume provide an important maternal history for Prunus and the groundwork for future studies on intergenomic sequence transfers, cytonuclear incompatibility, and conservation genetics.
The effects of venlafaxine on depressive-like behaviors and gut microbiome in cuprizone-treated mice
Authors: Du Chunhai , Zhang Tian , Feng Chong , Sun Qian , Chen ZhiGuo , Shen Xin , Liu Ying , Dai Gengwu , Zhang Xuan , Tang Nailong 
Published: June 2024

BackgroundCuprizone (CPZ)-treated mice show significant demyelination, altered gut microbiome, and depressive-like behaviors. However, the effects of venlafaxine (Ven) on the gut microbiome and depressive-like behavior of CPZ-treated mice are largely unclear.MethodsMale C57BL/6J mice were fed a chow containing 0.2% cuprizone (w/w) for 5 weeks to induce a model of demyelination. Meanwhile, the gut microbiota and depressive-like behaviors were assessed after the mice were fed with Ven (20 mg/kg/day) or equal volumes of distilled water for 2 weeks by oral gavage from the third week onward during CPZ treatment.ResultsCPZ treatment decreased the sucrose preference rate in the sucrose preference test and increased the immobility time in the tail-suspension test, and it also induced an abnormality in β-diversity and changes in microbial composition. Ven alleviated the depressive-like behavior and regulated the composition of the gut microbiota, such as the increase of Lactobacillus and Bifidobacterium in CPZ-treated mice.ConclusionThe anti-depressant effects of Ven might be related to the regulation of gut microbiota in the CPZ-treated mice.
Identification and Characterization of a Virulent Meloidogyne incognita Population Breaking Tomato Mi-1-Mediated Resistance in Indiana
Authors: Kunwar Vijay , Guan Wenjing , Zhang Lei 
Published: June 2024

High-tunnel production is increasing rapidly in the US due to its effectiveness in extending production seasons. Tomato is considered one of the most profitable crops grown in high tunnels. The elevated soil temperature and constant soil moisture in high tunnels lead to the buildup of root-knot nematodes (RKNs). Growing RKN-resistant tomato cultivars or grafting onto RKN-resistant tomato rootstocks is considered effective in managing RKNs. However, all of the RKN-resistant tomato cultivars or rootstocks carry the same resistance gene, Mi-1. This lack of diversity in resistance has led to the emergence of virulent RKN populations breaking tomato Mi-1 resistance. Here, we identified and characterized a virulent population of Meloidogyne incognita from a high tunnel in Indiana. The M. incognita population was confirmed as being able to infect and reproduce on two resistant tomato cultivars, Better Boy and Early Girl, carrying the Mi-1 gene, under a controlled environment at 24 °C. To our knowledge, this is the first report of a virulent M. incognita population breaking Mi-1 resistance in Indiana. Virulent M. incognita populations overcoming Mi-1 resistance were previously reported in California and Georgia in the US. This work emphasizes the importance of regularly monitoring RKN population virulence to sustainably manage the pest.
Completeness of provided information as a key aspect of successful counterparty verification completeness of provided information as a key aspect of successful verification of counterparty for its financial stability and reliability
Authors: Panishev I. A. 
Published: June 2024

The article presents the results of the analysis of Russian and foreign information and analytical systems conducted by the author of this article in the context of their methods and volumes of information collection. As a result of the study, a conclusion was made about the completeness and nature of the information provided to the user by information and analytical systems, as well as current shortcomings were highlighted and features that require further improvement and efficiency improvement in the use of such tools in the field of business and finance were emphasized.
Perspectiva del programa sembrando vida. Un enfoque de política pública y marco lógico
Authors: Gastélum Rosalinda Gámez 
Published: June 2024

Sinaloa es un estado mexicano con un alto grado de ruralización, con una economía sustentada mayormente en el sector primario; por lo que es relevante el análisis del programa sembrando vida del Gobierno Federal de apoyo al campo mexicano, el cual está enfocado a apoyar a los productores agrícolas de menores ingresos mediante el fomento al autoempleo y la reforestación del campo. Este programa es especialmente importante en una entidad como Sinaloa, México por sus características agropecuarias. La presente investigación tiene como objetivo realizar un análisis desde la perspectiva de políticas públicas al Programa Sembrando Vida. Se efectuó trabajo de campo en el municipio de El Fuerte (colindando con el municipio de Sinaloa de Leyva). a partir de una metodología cualitativa a través de la aplicación de cuestionarios a productores agrícolas, observación y entrevistas. También se utilizó Metodología del Marco Lógico (CEPAL, 2007), Gámez (2020) para evaluar los resultados del programa y sus efectos en la región geográfica de la comunidad Jiquilpan II. Esta investigación busca responder a la pregunta principal de investigación: ¿cuáles han sido los principales efectos del programa sembrando vidas en los productores agrícolas de la región de El Fuerte?
Los resultados de la investigación indican que el programa SV presenta fortalezas como reducir la migración, inclusión de la mujer y cultura del ahorro.
Sin embargo, también presenta áreas de oportunidad en su implementación, dado que el programa carece de supervisión en los viveros, los productores agrícolas están desforestando zonas agrícolas de pastizales para convertirlas en tierras de cultivo y justificar el apoyo que reciben. El apoyo que reciben es insuficiente.
Desarrollo y calidad embrionaria de un protocolo de superovulación en vacas Brahman en el distrito de Codo del Pozuzo, Huánuco, Perú
Authors: Marín Germany Yusep Gómez , Torre-Trinidad Lynn La , Farje-Muguruza Patricio , Vargas Jose Francisco Goicochea 
Published: June 2024

El objetivo del presente estudio fue evaluar el desarrollo y la calidad embrionaria, posterior a tratamientos superestimulatorios con hormona foliculoestimulante (FSH), en bovinos de producción de carne en la amazonia peruana. Para este trabajo se utilizaron 34 vacas de la raza Brahman con una condición corporal entre 3 y 4 Escala (1-5), a las cuales se les realizó un total de 90 colectas con un promedio de 2,65 ± 2 por vaca, luego de ser sincronizadas y superestimuladas según el Protocolo MOET: En el día (d) 0, a todas las vacas se les aplicó un implante subcutáneo (SC) en la parte media de la cara posterior de la oreja, conteniendo Norgestomet más Valerato de Estradiol - Crestar (Intervet). El d 4 en la mañana se iniciaron los tratamientos superestimulatorios utilizando un total de 300 y 220 miligramos (mg) de Folltropin (Vetoquinol, Canadá). Las vacas recibieron 8 aplicaciones de Folltropin intramuscular (IM) (dosis total: 300 mg) en forma decreciente cada 12 horas y por 4 d El d. 6 en la mañana y en la tarde recibieron 25 mg de Dinoprost (5 milititros de Lutalyse®). El d 7 de mañana se retiró el implante SC y el d 8 en la mañana, recibieron 0,0105 mg de Acetato de Buserelina (Intervet). El d 8 a la tarde y el d 9 en la mañana fueron inseminadas (IA), usando semen de reconocida fertilidad. Entre los 6 - 7 d posterior a la IA se colectaron los embriones y fueron evaluados según las normas de la International Embryo Technology Society (IETS). Los datos fueron analizados estadísticamente y se compararon las medias por el Test de Duncan y Tukey (P<0,05). En conclusión, de un total de 385 embriones recuperados en 90 colecciones, se obtuvo un promedio de 4,28 embriones colectados de todas las calidades y etapas embrionarias; se puede decir que más del 50% de etapas embrionarias son aptas para la transferencia embrionaria, de los cuales 44,93% fueron embriones buenos y solo 8,05% fueron embriones excelentes para las transferencias., según la nomenclatura de la IETS
تمايز الذات وعلاقته بمعايير اختيار شريك الحياة لدى طلبة جامعة اليرموك
Authors: Al-Khaldi Ghaida’a Mahmoud , Momani Fawwaz Ayoub 
Published: June 2024

هدفت الدراسة للتعرف إلى تمايز الذات وعلاقته بمعايير اختيار شريك الحياة لدى طلبة جامعة اليرموك، تكونت العينة من (813) طالبًا وطالبة. استخدم مقياس تمايز الذات ومقياس معايير اختيار شريك الحياة بعد التأكد من خصائصها السيكومترية. أظهرت النتائج أن مستويات جميع أبعاد تمايز الذات جاءت متوسطة باستثناء بعد (موقف الأنا) جاء بمستوى مرتفع. وأشارت النتائج إلى وجود فروق دالة إحصائيًا لجميع أبعاد تمايز الذات تعزى لمتغير الجنس باستثناء بعد (القطع العاطفي)، كما أظهرت النتائج وجود فروق لجميع أبعاد تمايز الذات تعزى لمتغير المستوى الدراسي، في حين لم تظهر فروق تعزى لمتغير مكان السكن والترتيب الولادي. وبينت النتائج أن جميع معايير اختيار شريك الحياة جاءت مرتفعة باستثناء (المعيار النفسي) جاء مرتفعاً جداً، وأشارت النتائج إلى وجود فروق دالة إحصائيًا لجميع المعايير تعزى لمتغير الجنس، ووجود فروق للمعيارين الاقتصادي والنفسي تعزى لمتغير المستوى الدراسي، وعدم وجود فروق للمعيارين الاجتماعي الثقافي والجسمي تعزى لمتغير المستوى الدراسي، وعدم وجود فروق تعزى لمتغير الترتيب الولادي على جميع المعايير، وعدم وجود فروق للمعيارين الاجتماعي الثقافي والاقتصادي تعزى لمتغير مكان السكن، ووجود فروق للمعيارين النفسي والجسمي تعزى لمكان السكن. وكشفت النتائج وجود علاقة ارتباطية موجبة ودالة إحصائيًا (ضعيفة، ضعيفة جداً) بين أبعاد تمايز الذات ومعايير اختيار شريك الحياة. وفي ضوء النتائج تم تقديم مجموعة من التوصيات أبرزها الحرص على توعيه الشباب والفتيات في معايير اختيار شريك الحياة، وتوعيتهم بأهمية تمايز الذات للاختيار الصحيح لشريك الحياة.
Sistem Informasi Manajemen Proyek Pembangunan PT. Tuffindo Investama Con
Authors: Chandra Fransiskus Daniel , Rachmadi Muhammad 
Published: June 2024

Technological developments cause all organizational and company actors to need information systems as a means of supporting operational activities. At PT. Tuffindo Investama Con, does not yet have an adequate system because it still uses a common system. The purpose of this research is to build a management information system that can assist the company in carrying out operational activities. The method used in this research is the RUP (Rational Undefined Process) method. At the inception stage, data collection and problem identification were carried out using interview and observation techniques. In the elaboration stage, problem analysis and needs analysis were carried out using PIECES analysis and cause and effect analysis. The construction stage is carried out by making applications and implementing application systems using class diagrams, activity diagrams and entity relationship diagrams. The programming language used is PHP and MySQL as the database server. The transition stage is carried out by testing the applications that have been made. The results of this study are expected to be able to build a project management information system that can help overcome the problems faced by PT. Tuffindo Investama Con and support daily operational activities, such as recording, project progress, calculations, and project transactions.

Keywords: Information System, Project Management, RUP, MySQL, PHP
Pengembangan Aplikasi Payroll Berbasis Web Pada Institusi Perguruan Tinggi (Studi Kasus di Universitas XYZ)
Authors: Nugraha Riko Rinaldiansyah , Purnama Giri 
Published: June 2024

Gaji merupakan bentuk pembayaran yang dilakukan secara berkala bedasarkan jangka waktu yang sudah ditetapkan kepada karyawan sesuai tugas-tugas dan pekerjaannya. Dalam penghitungan pembayaran gaji dilakukan menggunakan sistem payroll untuk mengatur setiap pembayaran jasa pegawai dengan efisien. Tujuan dari penilitian ini adalah untuk membantu proses perhitungan gaji karyawan di Universitas XYZ agar lebih cepat dan efisien dikarenakan selama ini dalam proses penghitungannya dilakukan secara manual pada aplikasi standalone yang dimana hal ini kurang efektif. Pada proses perancangannya menggunakan UML (Unified Modelling Language) dan pengembangan dilakukan dengan metode SDLC (System Development Life Cycle). Kemudian pembuatan aplikasi payroll ini menggunakan Framework Code Igniter 3 dengan database MySql. Dengan fitur dari aplikasi yaitu login admin, finance dan user, perhitungan gaji, dan cetak slip gaji. Adapun hasil dari penelitian ini adalah tersedianya rancangan pengembangan dan aplikasi sistem payroll pada Universitas XYZ untuk memproses penggajiannya.
Analisis Perbandingan Algoritma Kriptografi Simetris Dan Asimetris Dalam Meningkatkan Keamanan Sistem Informasi
Authors: Arif Zaenul , Nurokhman Akhmad 
Published: June 2024

Keamanan informasi menjadi sangat penting di masa sekarang ini. Ada teknik yang digunakan untuk meningkatkan keamanan data adalah dengan menggunakan teknologi kriptografi. Ada dua kriptografi yang umum digunakan yaitu kriptografi simetris dan kriptografi asimetris. Kedua kriptografi ini mempunyai keunggulan dan kelemahan masing-masing yang bisa mempengaruhi tingkat keamanan informasi yang dihasilkan. Oleh karena itu, perbandingan kinerja dan keamanan dari kedua jenis kriptografi tersebut perlu dilakukan untuk menentukan jenis kriptografi mana yang paling cocok digunakan dalam sistem informasi tertentu. Dalam penelitian ini, kami melakukan analisis perbandingan algoritma kriptografi simetris dan asimetris dalam meningkatkan keamanan sistem informasi. Penelitian ini dilakukan dengan melakukan tinjauan literatur dari studi sebelumnya, dan mempertimbangkan faktor-faktor seperti keamanan, efisiensi, dan kemudahan implementasi. Hasil dari penelitian ini menunjukkan bahwa kriptografi simetris lebih cepat dan lebih efisien dalam memproses data daripada kriptografi asimetris. Namun, kriptografi asimetris lebih aman dan dapat memberikan keamanan yang lebih baik terutama dalam komunikasi jarak jauh dan pembuatan tanda tangan digital. Oleh karena itu, pemilihan jenis kriptografi harus disesuaikan dengan kebutuhan sistem informasi yang digunakan.