bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple Access to Sol–Gel Precursors Bearing Fluorescent Aromatic Core Units
Authors: Hemgesberg Maximilian , Ohlmann Dominik M. , Schmitt Yvonne , Wolfe Monique R. , Müller Melanie K. , Erb Benjamin , Sun Yu , Gooßen Lukas J. , Gerhards Markus , Thiel Werner R. 
Published: February 2012

AbstractDi‐, tri‐, and tetrathienyl‐substituted polycyclic aromatic fluorophores were prepared from different aryldi‐, aryltri‐, or aryltetrahalides by a simple and fast Suzuki coupling. The reaction was optimized for the synthesis of the desired materials on multigram scale. The coupled products were converted into the corresponding iodides through iodination with N‐iodosuccinimide. The iodides turned out to be versatile starting materials for applications, such as periodic mesoporous organosilica syntheses. They were converted into a variety of new trimethoxysilyl arenes by using a very efficient Pd‐mediated C–Si cross‐coupling, which was also extended to the corresponding thienyl bromides by using a dimeric PdI catalyst. All compounds were characterized by 1H NMR, 13C NMR, 29Si NMR, and ATR‐IR spectroscopy and HRMS.
The organization of intrinsic brain activity differs between genders: A resting‐state fMRI study in a large cohort of young healthy subjects
Authors: Filippi Massimo , Valsasina Paola , Misci Paolo , Falini Andrea , Comi Giancarlo , Rocca Maria A. 
Published: February 2012

AbstractObjectives: To investigate, using resting state (RS) functional MRI (fMRI), gender‐related differences of functional connectivity (FC) and functional network connectivity (FNC) of the human brain. Experimental design: One‐hundred and four young healthy subjects (48/56 men/women), aged between 20 and 29 years, underwent a 10‐min RS fMRI acquisition. Independent component analysis (ICA) and statistical parametric mapping were used to assess gender‐related differences in RSNs, with and without correction for regional gray matter (GM) volume. The relationships among all RSNs was also assessed using a FNC method. Principal observations: For all networks, significant between‐group differences of RS activity were found. Between‐group comparisons of RSNs changed when adjusting for GM volume, as follows: (1) there was only marginal effect on the analysis of sensory (i.e., sensorimotor, visual, and auditory) networks; and (2) there was a significantly increased difference when cognitive networks (apart from one related to attention) were considered. Compared with women, men experienced increased FC in parietal and occipital regions in most RSNs, whereas women experienced a higher RS FC in frontal and temporal regions, and in the cerebellum. When compared to women, increased FNC was found in men between several cognitive and sensory networks, whereas women showed an increased FNC only between attention and right working‐memory networks. Conclusions: The organization of intrinsic FC and FNC differ between genders. The detected differences could contribute to the understanding of the known between‐gender variation in task‐related recruitments, and the patterns of abnormalities detected in neurologic and psychiatric diseases with a gender prevalence. Hum Brain Mapp, 2013. © 2012 Wiley Periodicals, Inc.
1‐hydroxy‐1,1‐bis(H‐phosphinates): Synthesis, stability, and sorption properties
Authors: David Tomáš , Křečková Pavlína , Kotek Jan , Kubíček Vojtěch , Lukeš Ivan 
Published: February 2012

AbstractA synthesis of 1‐hydroxy‐1,1‐bis(H‐phosphinates) from acylchlorides is described. Solid‐state structures of two bis(phosphinates) determined by X‐ray diffraction showed variations in the PC distances. The compounds show negligible sorption on hydroxyapatite and an intermediate chemical stability in aqueous solution. The hydrolysis occurs in acidic as well as alkaline media. Hydrolysis rates of four derivatives show the lowest stability for aromatic derivatives as a result of the electron‐withdrawing effect. Main products of hydrolysis are 1‐hydroxy‐(H‐phosphinates) and phosphorous acid. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:195–201, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21003
Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways
Authors: Seki Naoko , Toh Uhi , Kawaguchi Koji , Ninomiya Masayuki , Koketsu Mamoru , Watanabe Kunitomo , Aoki Masatora , Fujii Teruhiko , Nakamura Anna , Akagi Yoshito , Kusukawa Jingo , Kage Masayoshi , Shirouzu Kazuo , Yamana Hideaki 
Published: February 2012

Abstract4′,5,7‐Trihydroxy‐3′,5′‐dimethoxyflavone (Tricin), a naturally occurring flavone, has anti‐inflammatory potential and exhibits diverse biological activities including antigrowth activity in several human cancer cell lines and cancer chemopreventive effects in the gastrointestinal tract of mice. The present study aimed to investigate the biological actions of tricin on hepatic stellate cells (HSCs) in vitro, exploring its potential as a treatment of liver fibrosis, since HSC proliferation is closely related to the progression of hepatic fibrogenesis in chronic liver diseases leading to irreversible liver cirrhosis and hepatocellular carcinoma. Tricin inhibited platelet‐derived growth factor (PDGF)‐BB‐induced cell proliferation by blocking cell cycle progression and cell migration in the human HSC line LI90 and culture‐activated HSCs. It also reduced the phosphorylation of PDGF receptor β and the downstream signaling molecules ERK1/2 and Akt, which might be due to its tyrosine kinase inhibitor properties rather than inhibition of the direct binding between PDGF‐BB and its receptor. Our findings suggest that tricin might be beneficial in HSC‐targeting therapeutic or chemopreventive applications for hepatic fibrosis. J. Cell. Biochem. 113: 2346–2355, 2012. © 2012 Wiley Periodicals, Inc.
Successful risk assessment may not always lead to successful risk control: A systematic literature review of risk control after root cause analysis
Authors: Card Alan J. , Ward James , Clarkson P. John 
Published: February 2012

AbstractRoot cause analysis is perhaps the most widely used tool in healthcare risk management, but does it actually lead to successful risk control? Are there categories of risk control that are more likely to be effective? And do healthcare risk managers have the tools they need to support the risk control process? This systematic review examines how the healthcare sector translates risk analysis to risk control action plans and examines how to do better. It suggests that the hierarchy of risk controls should inform risk control action planning and that new tools should be developed to improve the risk control process.
Nurse staffing and skill mix patterns: Are there differences in outcomes?
Authors: Esparza Salvador J. , Zoller James S. , White Andrea Weatherby , Highfield Martha E. F. 
Published: February 2012

AbstractThe purpose of this study was to examine the impact on patient outcomes of nurse staffing and registered nurse (RN) skill mix patterns used by medical‐surgical units in California hospitals after enactment of nurse‐to‐patient staffing ratio laws, and determine if there are differences in patient outcomes for conditions that are considered sensitive to nursing care. Results from this study demonstrated an association between total nursing hours per patient day (NHPPD) and two outcomes: urinary tract infections (UTI) and length of stay (LOS). A stronger association was observed between the RN proportions of the total nursing hours of care and the same outcomes. The higher the total NHPPD and RN proportion, the lower the LOS and the lower the odds of hospitalized patients' developing UTI.
Diffusion‐weighted MRI as an adjunct to mammography in women under 50 years of age: An initial study
Authors: Kazama Toshiki , Kuroki Yoshifumi , Kikuchi Mari , Sato Yasunori , Nagashima Takeshi , Miyazawa Yukimasa , Sakakibara Masahiro , Kaneoya Katsuhiko , Makimoto Yumi , Hashimoto Hideyuki , Motoori Ken , Takano Hideyuki 
Published: February 2012

AbstractPurpose:To evaluate diffusion‐weighted magnetic resonance (DW) imaging as an adjunct to mammography for the detection of small invasive breast cancer.Materials and Methods:Institutional review board standards were followed for this retrospective study. We performed both breast DW imaging and mammography on 25 women under 50 years of age with pathologically proven T1 breast cancer and on 21 healthy women under 50 years of age. Four offsite radiologists blind to the clinical information independently interpreted the mammograms and DW images and then classified their confidence level regarding the presence of breast cancer. The composite area under receiver operating characteristic curve (AUC), of mammography alone, DW imaging alone, and the combination of DW imaging and mammography (DWI/Cal) were calculated.Results:The AUC of composite ROC curves of mammography, DW imaging, DWI/Cal combination, was 0.79 (95% CI, 0.72–0.87), 0.86 (95% CI, 0.84–0.87), and 0.96 (95% CI, 0.92–1.00), respectively.Conclusion:DW imaging may be a useful adjunct to mammography in the detection of small invasive breast cancer in women under 50 years of age. J. Magn. Reson. Imaging 2012;36:139–144. © 2012 Wiley Periodicals, Inc.
Brain‐derived neurotrophic factor modulates N‐methyl‐D‐aspartate receptor activation in a rat model of cancer‐induced bone pain
Authors: Wang Li‐Na , Yang Jian‐Ping , Ji Fu‐hai , Zhan Ying , Jin Xiao‐hong , Xu Qi‐Nian , Wang Xiu‐Yun , Zuo Jian‐Ling 
Published: February 2012

AbstractBrain‐derived neurotrophic factor (BDNF) released within the spinal cord induces phosphorylation of N‐methyl‐D‐aspartate (NMDA) receptors on the spinal cord neurons. This process is necessary for maintaining pain hypersensitivity after nerve injury. However, little is known about the role of BDNF and NMDA receptors in cancer‐induced bone pain (CIBP), whose features are unique. This study demonstrates a critical role of the BDNF‐modulated NMDA subunit 1 (NR1) in the induction and maintenance of behavioral hypersensitivity in a rat model of CIBP, both in the spinal cord and in the dorsal root ganglia (DRG). We selectively suppressed BDNF expression by RNA interference (RNAi) using intrathecal administration of BDNF small interfering RNA (siRNA). Then, we assessed mechanical threshold and spontaneous pain in CIBP rats. Real‐time PCR, Western blotting, and fluorescent immunohistochemical staining were used to detect BDNF or NR1 both in vivo and in vitro. BDNF and phospho‐NR1 were expressed under CIBP experimental conditions, with expression levels peaking at day 6 (BDNF) or 9 (NR1). Intrathecal BDNF siRNA prevented CIBP at an early stage of tumor growth (days 4–6). However, at later stages (days 10–12), intrathecal BDNF siRNA only attenuated, but did not completely block, the established CIBP. BDNF‐induced NMDA receptor activation in the spinal cord or DRG leads to central sensitization and behavioral hypersensitivity. Thus, BDNF might provide a targeting opportunity for alleviating CIBP. © 2012 Wiley Priodicals, Inc.
Historical landscape photographs for calibration of Landsat land use/cover in the northern Ethiopian highlands
Authors: de Mûelenaere S. , Frankl A. , Haile M. , Poesen J. , Deckers J. , Munro N. , Veraverbeke S. , Nyssen J. 
Published: February 2012

ABSTRACTThe combined effects of erosive rains, steep slopes and human land use have caused severe land degradation in the Ethiopian Highlands for several thousand years, but since the 1970s, however, land rehabilitation programmes have been established to try to reverse deterioration. In order to characterize and quantify the transformations in the north Ethiopian Highlands, a study was carried out over 8884 km2 of the Tigray Highlands of northern Ethiopia. Using Landsat Multispectral Scanner and later Thematic Mapper imagery (1972, 1984/1986 and 2000), historical terrestrial photographs (1974–1975) and fieldwork (2008), we prepared land use and cover maps. For assessing the use of the historical terrestrial photographs, Landsat images from 1972 were classified using two different methods, namely conventional change detection (image differencing) and ground truthing (using the historical photographs of 1974–1975). Results show that the use of terrestrial photographs is promising, as the classification accuracy based on this method (Kappa coefficient 0·54) is better than the classification accuracy of the method based on image differencing (Kappa coefficient 0·46). Major land use and cover changes indicate the following: (1) a gradual but significant decline in bare ground (32 per cent in 1972 to 8 per cent in 2000); (2) a significant increase of bushland (25 to 43 per cent) and total forest area (including eucalypt plantations, 2·6 to 6·3 per cent); and (3) creation of numerous lakes and ponds. The dominant change trajectory (27 per cent of the study area) indicates a gradual or recent vegetation increase. These changes can be linked to the population growth and the introduction of land rehabilitation initiatives, complemented by growing awareness of land holders. Copyright © 2012 John Wiley & Sons, Ltd.
Quality assessment of spontaneous triggered adverse event reports received by the Food and Drug Administration
Authors: Brajovic Sonja , Piazza‐Hepp Toni , Swartz Lynette , Dal Pan Gerald 
Published: February 2012

ABSTRACTPurposeThe Food and Drug Administration (FDA) conducted a quality assessment of the Adverse Drug Events Spontaneous Triggered Event Reporting (ASTER) pilot study, which represented the FDA's first experience with the receipt of electronic health record (EHR)–triggered adverse event reports. The EHR‐triggered adverse event reports from ASTER were evaluated for their utility in conducting FDA's pharmacovigilance work. FDA is sharing these findings to assist others who are pursuing the use of patient EHR data for electronic adverse event identification and reporting.MethodsASTER pilot study reports were identified from the FDA Adverse Event Reporting System database, then reviewed and assessed.ResultsDemographic and other objective data that can be easily derived from EHRs were both present in the submitted reports and relevant to the reported adverse drug event (ADE), but other data, such as an informative description of the ADE, dates that support a temporal relationship between the product and the event, and relevant laboratory data, were often either conflicting or lacking. Most of the ADEs captured in the ASTER pilot and reported to FDA are known events (i.e. included in product labeling) for the suspect drugs.ConclusionTriggered adverse event reporting from patient EHRs is a potentially valuable source of postmarketing safety information, especially for known adverse events. Attention to quality is needed to ensure that the data generated from EHR‐triggered ADE reporting systems are relevant to the reported adverse events so that the FDA and others engaged in pharmacovigilance can fully utilize these reports. Published 2012. This article is a US Government work and is in the public domain in the USA.
Phosphine‐induced walking response of the lesser grain borer (Rhyzopertha dominica)
Authors: Pimentel Marco Aurélio G , Faroni Leda Rita A , Corrêa Alberto S , Guedes Raul Narciso C 
Published: February 2012

AbstractBACKGROUND: In spite of the intensive worldwide use of phosphine against stored‐product insects, its potential sublethal effects on targeted insect species is seldom recognised and may compromise the efficacy of this fumigant, particularly against phosphine‐resistant insects. Therefore, the behavioural response of three populations of the lesser grain borer Rhyzopertha dominica (Coleoptera: Bostrichidae) to sublethal phosphine exposure was assessed.RESULTS: Concentration‐mortality bioassays with phosphine confirmed the resistance status of the insect populations studied, with levels of phosphine resistance of 40.8‐fold and 85.7‐fold compared with the susceptible population. Regarding walking behaviour, determined using a digital video‐tracking system, the phosphine‐resistant populations were less active than the susceptible population. In addition, sublethal phosphine exposure decreased the walking activity of all three populations.CONCLUSION: Phosphine exposure decreased walking ativity. Such reduced walking activity is likely to lower the respiration rate, thereby minimising phosphine uptake. As higher phosphine resistance was also associated with reduced walking activity, phosphine‐resistant populations may resist phosphine fumigation even more efficiently on account of this behavioural trait, further aiding their physiological resistance, and should be a matter of concern. Copyright © 2012 Society of Chemical Industry
Flow Stress and Critical Dynamic Recrystallization Behavior of Cu–Fe16Mn0.6C High Manganese TWIP Steel
Authors: Gaofei Liang , Changqing Lin , Yuan Fang 
Published: February 2012

AbstractThe true stress–strain curve of Cu–Fe16Mn0.6C twinning induced plasticity (TWIP) steel was studied with a compression test on Thermecmastor‐Z thermal simulator at a temperature range of 850–1150°C and strain rate range of 0.03–30 s−1. The influence of deformation temperature and strain rate on high‐temperature flow stress and critical recrystallization behavior of the TWIP steel was investigated. It is concluded that the peak flow stress of Cu–Fe16Mn0.6C under high‐temperature deformation decreases as the temperature increases but increases with the strain rate. Meanwhile at strain rate of 0.03 and 30 s−1 obvious peak stresses are observed which demonstrates the dynamic recrystallization. The constitutive equation of Cu–Fe16Mn0.6C under high temperature deformation is calculated by linear regression method. The activation energy is 505 kJ mol−1. The relationship between critical strain of dynamic revrystallization and Zener–Hollomon parameter is determined by the curve between strain‐hardening rate and flow stress.
Delay analysis in practical wireless network coding
Authors: Li Huanzhong , Liu Xue , He Wenbo , Yang Wei , Dou Wenhua 
Published: February 2012

ABSTRACTNetwork coding provides a powerful mechanism for improving performance of wireless networks. In this paper, we present an analytical approach for end‐to‐end delay analysis in wireless networks that employs inter‐session network coding. Prior work on performance analysis in wireless network coding mainly focuses on the throughput of the overall network. Our approach aims to analyze the delay of each flow in the network. The theoretical basis of our approach is network calculus. In order to use network calculus to analyze the performance of traffic flows in the network, we have to address three specific problems: identifying traffic flows, characterizing broadcast links, and measuring coding opportunities. We propose solutions for these problems and discuss the practical issues when applying the approach in practice. We make three main contributions. First, we obtain theoretical formulations for computing the queueing delay bounds of traffic flows in wireless networks with network coding. Second, with the formulations, we figure out the factors that affect the queueing delay of a flow and find that first‐in first‐out scheduling cannot fully exploit the benefit of network coding. Third, in order to exploit our findings, we introduce a new scheduling scheme that can improve the performance of current practical wireless network coding. Copyright © 2012 John Wiley & Sons, Ltd.
Comparison of pregnancy detection methods in live white‐tailed deer
Authors: Duquette Jared F. , Belant Jerrold L. , Beyer Dean E. , Svoboda Nathan J. 
Published: February 2012

AbstractAssessing ungulate reproduction is important to biologists for managing populations and predicting trends. We compared efficacy of trans‐abdominal ultrasound and pregnancy‐specific protein B (PSPB) white‐tailed deer (Odocoileus virginianus) pregnancy estimates, respectively, from January to mid‐April 2009–2011 in the south‐central Upper Peninsula of Michigan, USA. We observed a strong agreement (K = 0.68, SE = 0.13, 95% CI = 0.42–0.94) of PSPB and ultrasound in categorizing pregnant and nonpregnant deer. Five deer were determined to be pregnant by ultrasound but not by PSPB and 6 females were judged to be nonpregnant using either method. Total cost for PSPB testing of 101 deer was US$2,220, whereas ultrasound equipment cost US$14,150. Trans‐abdominal ultrasound and PSPB provided accurate detection of pregnancy in live white‐tailed deer. We recommend PSPB for studies testing comparatively small numbers (up to several hundred) of deer. However, we recommend ultrasonography if real‐time pregnancy determination is needed (e.g., vaginal implant transmitter use), particularly for large numbers (i.e., several hundred to thousands) of deer. © 2012 The Wildlife Society.
Synthesis, Reactivity and Structures of Iridium Tetrafluoropyridyl Complexes: Ammonia Coordination and Activation
Authors: Jungton Ann‐Katrin , Kläring Paul , Braun Thomas , Eißler Anna 
Published: February 2012

AbstractAbstract. The complex cis‐trans‐[Ir(4‐C5NF4)(H)2(PiPr3)2] (1) reacted with ammonia to give cis‐trans‐[Ir(4‐C5NF4)(H)2(NH3)(PiPr3)2] (2a). The reaction of 1 with ND3 yielded the isotopomer cis‐trans‐[Ir(4‐C5NF4)(H)2(ND3)(PiPr3)2] (2b). Within two weeks hydrido ligands were replaced by metal bound deuterium atoms via H/D exchange. Treatment of trans‐[Ir(4‐C5NF4)(η2‐C2H4)(PiPr3)2] (3) with HCl led to the formation of trans‐[Ir(4‐C5NF4)(Cl)(H)(PiPr3)2] (4). Complex 4 reacted with CO or ammonia to give trans‐[Ir(4‐C5NF4)(Cl)(H)(CO)(PiPr3)2] (5) and the ammine complex trans‐[Ir(4‐C5NF4)(Cl)(H)(NH3)(PiPr3)2] (6a), respectively. The cationic species [(η6‐C6H6)Ir(H)2(PiPr3)][PF6] (7) was obtained by reaction of cis‐trans‐[Ir(4‐C5NF4)(H)2(NH3)(PiPr3)2] (2a) or cis‐trans‐[Ir(4‐C5NF4)(H)2(PiPr3)2] (1) with [Ph3C][PF6] in benzene.
Clinical overview and treatment options for non‐skeletal manifestations of mucopolysaccharidosis type IVA
Authors: Hendriksz Christian J. , Al‐Jawad Maisoon , Berger Kenneth I. , Hawley Sara M. , Lawrence Rebecca , Mc Ardle Ciarán , Summers C. Gail , Wright Elizabeth , Braunlin Elizabeth 
Published: February 2012

AbstractMucopolysaccharidosis type IVA (MPS IVA) or Morquio syndrome is a multisystem disorder caused by galactosamine‐6‐sulfatase deficiency. Skeletal manifestations, including short stature, skeletal dysplasia, cervical instability, and joint destruction, are known to be associated with this condition. Due to the severity of these skeletal manifestations, the non‐skeletal manifestations are frequently overlooked despite their significant contribution to disease progression and impact on quality of life. This review provides detailed information regarding the non‐skeletal manifestations and suggests long‐term assessment guidelines. The visual, auditory, digestive, cardiovascular, and respiratory systems are addressed and overall quality of life as measured by endurance and other functional abilities is discussed. Impairments such as corneal clouding, astigmatism, glaucoma, hearing loss, hernias, hepatomegaly, dental abnormalities, cardiac valve thickening and regurgitation, obstructive sleep apnea, tracheomalacia, restrictive and obstructive respiratory compromise, and muscular weakness are discussed. Increased awareness of these non‐skeletal features is needed to improve patient care.