bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between calcium channel blockers and gingival hyperplasia
Authors: Kaur Gaganpreet , Verhamme Katia M. C. , Dieleman Jeanne P. , Vanrolleghem Ann , Van Soest Eva M. , Stricker Bruno H. Ch. , Sturkenboom Miriam C. J. M. 
Published: June 2010

Kaur G, Verhamme KMC, Dieleman JP, Vanrolleghem A, van Soest EM, Stricker BHCh, Sturkenboom MCJM. Association between calcium channel blockers and gingival hyperplasia. J Clin Periodontol 2010; 37: 625–630. doi: 10.1111/j.1600‐051X.2010.01574.x.AbstractAim: To study the effect of the dose and type of calcium channel blockers (CCBs) on the risk of gingival hyperplasia and to quantify this association.Methods: The study was conducted within the Integrated Primary Care Information Project in The Netherlands. A nested case–control study was designed within a cohort of all patients who were new users of either CCBs or drugs interacting with the renin–angiotensin system (RAS). Cases were all individuals with a validated diagnosis of gingival hyperplasia. Controls were matched on age, gender and index date.Results: Within the study population, 103 cases of gingival hyperplasia were identified and matched to 7677 controls. The risk of gingival hyperplasia was higher in current users of CCBs [adjusted odds ratio (ORadj) 2.2, 95% confidence intervals (95% CI): 1.4–3.4], especially in dihydropyridines (ORadj 2.1, 95% CI: 1.3–3.5) and benzothiazepine derivatives (ORadj 2.9, 95% CI: 1.3–6.5) than in RAS drug users. The risk increased in patients using more than the recommended daily dose (ORadj 3.0, 95% CI: 1.6–5.5) and when the duration of current use was <1 month (ORadj 5.2, 95% CI: 2.1–12.6).Conclusion: This study shows that the risk of gingival hyperplasia is twofold higher in current users of CCBs than in users of RAS drugs. The association was dose dependent and the highest for dihydropyridines or benzothiazepine derivates.
Soft tissue volume augmentation by the use of collagen‐based matrices: a volumetric analysis
Authors: Thoma Daniel S. , Jung Ronald E. , Schneider David , Cochran David L. , Ender Andreas , Jones Archie A. , Görlach Christoph , Uebersax Lorenz , Graf‐Hausner Ursula , Hämmerle Christoph H. F. 
Published: June 2010

Thoma DS, Jung RE, Schneider D, Cochran DL, Ender A, Jones AA, Görlach C, Uebersax L, Graf‐Hausner U, Hämmerle CHF. Soft tissue volume augmentation by the use of collagen‐based matrices: a volumetric analysis. J Clin Peridontol 2010; 37: 659–666. doi: 10.1111/j.1600‐051X.2010.01581.x.AbstractObjectives: The aim was to test whether or not soft tissue augmentation with a newly developed collagen matrix (CM) leads to volume gain in chronic ridge defects similar to those obtained by an autogenous subepithelial connective tissue graft (SCTG).Material and Methods: In six dogs, soft tissue volume augmentation was performed by randomly allocating three treatment modalities to chronic ridge defects (CM, SCTG, sham‐operated control). Impressions were taken before augmentation (baseline), at 28, and 84 days. The obtained casts were optically scanned and the images were digitally analysed. A defined region of interest was measured in all sites and the volume differences between the time points were calculated.Results: The mean volume differences per area between baseline and 28 days amounted to a gain of 1.6 mm (CM; SD±0.9), 1.5 mm (SCTG; ±0.1), and a loss of 0.003 mm (control; ±0.3). At 84 days, the mean volume differences per area to baseline measured a gain of 1.4 mm (CM; ±1.1), 1.4 mm (SCTG; ±0.4), and a loss of 0.3 mm (control; ±0.3). The differences between CM and SCTG were statistically significant compared with control at 28 and 84 days (p<0.001).Conclusion: Within the limits of this animal study, the CM may serve as a replacement for autogenous connective tissue.
Regulatory T cells attenuate experimental periodontitis progression in mice
Authors: Garlet Gustavo P. , Cardoso Cristina R. , Mariano Flavia S. , Claudino Marcela , De Assis Gerson F. , Campanelli Ana P. , Ávila‐Campos Mario J. , Silva João S. 
Published: June 2010

Garlet GP, Cardoso CR, Mariano FS, Claudino M, de Assis GF, Campanelli AP, Ávila‐Campos MJ, Silva JS. Regulatory T cells attenuate experimental periodontitis progression in mice. J Clin Periodontol 2010; 37: 591–600. doi: 10.1111/j.1600‐051X.2010.01586.x.AbstractAims: The aim of this study was to identify the presence and characterize the function of regulatory T cells (Tregs) in experimental periodontitis in mice.Material and Methods: C57Bl/6 mice infected with Actinobacillus actinomycetemcomitans, treated or not with anti‐glucocorticoid‐inducible tumour necrosis factor receptor (anti‐GITR) to inhibit Tregs function, were analysed regarding inflammatory cell and Tregs influx, alveolar bone loss and cytokine expression/production (analysed by real‐time polymerase chain reaction and ELISA) throughout experimental periodontitis.Results: A. actinomycetemcomitans inoculation in mice resulted in periodontal disease characterized by marked alveolar bone loss and an influx of inflammatory cells. Flow cytometry evaluation of inflammatory cells demonstrated an increased number of CD4+CD25+ and CD4+FOXp3+ cells, characterizing the presence of Tregs in the periodontal environment in a late stage after infection. Tregs‐associated cytokines interleukin‐10 (IL‐10), cytotoxic T lymphocyte‐associated molecule 4 (CTLA‐4) and transforming growth factor‐β (TGF‐β) were found to be expressed/produced in a kinetics that resembles Tregs migration. Treatment with anti‐GITR, which inhibits Tregs function, showed increased alveolar bone loss and inflammatory cell migration. A reduction in IL‐10, CTLA‐4 and TGF‐β levels was also observed, while interferon‐γ, tumour necrosis factor‐α and receptor activator for nuclear factor κB ligand levels were increased. However, bacterial load and C‐reactive protein serum did not show any differences.Conclusion: Taken together, our results showed that the presence of Treg cells attenuates the severity of experimental periodontitis without impairment in the control of infection.
Persistent pruritic papules and plaques: a characteristic histopathologic presentation seen in a subset of patients with adult‐onset and juvenile Still's disease
Authors: Fortna Ryan R. , Gudjonsson Johann E. , Seidel Gregory , DiCostanzo Damian , Jacobson Mark , Kopelman Margaret , Patel Rajiv M. 
Published: June 2010

Background:‘Persistent pruritic papules and plaques' of Still's disease represents a recently described eruption seen in a subset of patients. Most cases reported in the literature to date have been associated with adult‐onset Still's disease. Methods: We present the clinical and histopathologic examinations of three female patients ranging in age from 15 to 54 years. Results: Our three patients each presented with clinical findings consistent with Still's disease. The youngest patient suffered from the juvenile form of Still's disease (systemic‐onset juvenile rheumatoid arthritis). Each patient had a persistent, pruritic eruption with histopathologic findings of dyskeratosis confined to the upper layers of the epidermis as well as a sparse superficial dermal infiltrate containing scattered neutrophils. Conclusions: These cases confirm the characteristic clinical and histopathologic findings of ‘persistent papules and plaques of Still's disease’ and show the potential for this eruption in both the adult and juvenile age groups.Fortna RR, Gudjonsson JE, Seidel G, DiCostanzo D, Jacobson M, Kopelman M, Patel RM. Persistent pruritic papules and plaques: a characteristic histopathologic presentation seen in a subset of patients with adult‐onset and juvenile Still's disease.
Low‐dose rituximab in adult patients with primary immune thrombocytopenia
Authors: Zaja Francesco , Vianelli Nicola , Volpetti Stefano , Battista Marta Lisa , Defina Marzia , Palmieri Salvatore , Bocchia Monica , Medeot Marta , De Luca Stefano , Ferrara Felicetto , Isola Miriam , Baccarani Michele , Fanin Renato 
Published: June 2010

Abstract Backgrounds: Rituximab 375 mg/m2 weekly for 4 wks has significant activity in adults with primary immune thrombocytopenia (ITP). In this setting, several evidences support the possible use of lower doses of rituximab. Objectives: To investigate the activity of low‐dose rituximab as salvage therapy in previously treated symptomatic ITP. Methods: Forty‐eight adult patients were treated prospectively with rituximab 100 mg weekly for 4 wks. Results: Overall and complete responses (CR) (platelet level ≥ 50 and 100 × 109/L) were 60.5% and 39.5%, respectively. In responders, the median time to response was 35 d (range: 7–112 d). The median time of observation was 18 months (range 3–49 months). Sixteen of 29 responding patients (55%) relapsed and 14 needed further treatments. The 12‐ and 24‐month cumulative relapse‐free survival was 61% and 45%, respectively. In univariate analysis, CR rate was in inverse relation with weight OR = 0.95, CI95% [0.91; 0.99] (P = 0.019) and age OR=0.96, CI95% [0.93; 0.99] (P = 0.047). Cox regression model showed that relapse probability increases as weight (HR = 1.06, CI95% [1.0031; 1.111]) and period between diagnosis and rituximab therapy (HR = 1.01, CI95% [1.002; 1.017]) increase. One patient developed an interstitial pneumonia 1 month after the end of rituximab treatment. No other infectious, hematologic or extra‐hematologic complications were documented during follow‐up. Conclusions: Low‐dose rituximab is active in ITP but has moderate long‐term effect. A comparative study with standard dose is warranted.
Relative influences of catchment‐ and reach‐scale abiotic factors on freshwater fish communities in rivers of northeastern Mesoamerica
Authors: Esselman P. C. , Allan J. D. 
Published: June 2010

Esselman PC, Allan JD. Relative influences of catchment‐ and reach‐scale abiotic factors on freshwater fish communities in rivers of northeastern Mesoamerica. Ecology of Freshwater Fish 2010: 19: 439–454. © 2010 John Wiley & Sons A/SAbstract –  While the abiotic factors important to freshwater fish assemblages at a reach scale are well understood, studies of larger scale constraints have yielded variable conclusions, spurring a need for further studies in new biogeographic contexts. This study investigated the importance of catchment‐ and reach‐scale abiotic factors to variation in freshwater fish assemblages in rivers of northeastern Mesoamerica. Abiotic variables and fish data from 72 sampling sites on main stem rivers of Belize were used with partial constrained ordination to determine the proportion of spatially structured and unstructured variation in fish presence and absence, relative abundance, and community metrics explained by catchment‐ and reach‐scale environmental factors. Results showed that, combined, catchment and reach variables explained a large portion of the total variation in the fish assemblage data (54–75%), and that catchment environment explained a greater portion of variation (42–63%) than reach environment (34–50%). Variables representing landscape position (local elevation, watershed area) and their reach‐level correlates (channel width, depth variation, and substrate) correlated strongly to the fish assemblage data. Our results suggest that landscape‐scale factors have a stronger relative influence on assemblages than environmental conditions at the reach scale within our study area. These results contrast with past findings that showed greater local scale influence in landscapes with low anthropogenic disturbance levels. Our findings suggest that biodiversity conservation efforts should consider assemblage variation across a longitudinal gradient, and that a multi‐catchment region is a biologically relevant scale for fish conservation planning and coordination in northeastern Mesoamerica.
Somatic symptoms as a marker for severity in adolescent depression
Authors: Bohman Hannes , Jonsson Ulf , Von Knorring Anne‐Liis , Von Knorring Lars , Päären Aivar , Olsson Gunilla 
Published: June 2010

AbstractAim:  This study aims to investigate the prevalence of somatic symptoms in depressed adolescents and in their healthy peers. A second aim is to investigate the correlation, in the depressed adolescents, between the number of somatic symptoms and severe concurrent symptoms, signs and life events.Methods:  The total population of 16–17 year olds – in the city of Uppsala – was screened for depression and then interviewed using a structured interview questionnaire. Depressed subjects and matched controls were identified. A total of 177 pairs were used for pair‐wise analyses of somatic symptoms. Severe symptoms, signs and life events were selected for analysing their relation to depression with somatic symptoms.Results:  The adolescents with depressive disorders experienced considerably more somatic symptoms than their healthy controls. The duration and depth of the depression correlated with the number of somatic symptoms. There was a strong correlation between depression with many somatic symptoms and suicidal plans/thoughts, suicidal attempts, disruptive behaviour, as well as multiple stressful relationships.Conclusion:  This study demonstrates that somatic symptoms are common in adolescent depression. Multiple somatic symptoms within depression imply a higher severity in terms of duration, depth and psychiatric comorbidity. The strong correlation with suicidal plans, suicidal attempts and disruptive behaviour is concerning.
Effects of Photodynamic Therapy Using Hematoporphyrin Monomethyl Ether on Experimental Choroidal Neovascularization
Authors: Fan Sijun , Qiu Haixia , Huang Houbin , Gu Ying , Zeng Jing 
Published: June 2010

AbstractHematoporphyrin monomethyl ether (HMME) is a novel and promising second‐generation porphyrin‐related photosensitizer for photodynamic therapy (PDT). To study the effects of HMME PDT on choroidal neovascularization (CNV) in rats, the PDT was performed 20 min after HMME bolus injection, which was investigated prior to the PDT by fluorescence microscopy with laser‐induced CNV, and delivered at an irradiance of 400, 600 and 1000 mW cm−2 corresponding to a fluence of 36, 54, 90 J cm−2 in PDT plan I (15 mg kg−1 HMME). In PDT plan II (30 mg kg−1 HMME), the laser had a constant irradiance of 600 mW cm−2, which was delivered for 60, 90 or 150 s, to also achieve total energy doses of 36, 54 or 90 J cm−2. CNV closure rates assessed by fluorescein angiography and histologic damage to treated areas of choroid and retina varied as a function of the dose of HMME and of the activating light energy fluence. Endothelial cell labeled by platelet/endothelial cell adhesion molecule‐1 presented treated CNV lesions that were significantly reduced in size (P < 0.01). It can be concluded that PDT using HMME can effectively occlude CNV. HMME is a potentially useful photosensitizer for the reduction in CNV size of irradiated areas.
Fractionated Illumination at Low Fluence Rate Photodynamic Therapy in Mice
Authors: Middelburg Tom A. , Van Zaane Floor , De Bruijn Henriëtte S. , Van Der Ploeg‐van den Heuvel Angelique , Sterenborg Henricus J. C. M. , Neumann H. A. Martino , De Haas Ellen R. M. , Robinson Dominic J. 
Published: June 2010

AbstractPhotodynamic therapy (PDT) for actinic field cancerization is effective but painful. Pain mechanisms remain unclear but fluence rate has been shown to be a critical factor. Lower fluence rates also utilize available oxygen more efficiently. We investigated PDT effect in normal SKH1‐HR mice using low and high fluence rate aminolevulinic acid (ALA) PDT and a fractionated illumination scheme. Six groups of six mice with different light treatment parameters were studied. Visual skin damage was assessed up to 7 days post‐PDT. Fluorescence and reflectance spectroscopy during illuminations provided us with real‐time information about protoporphyrin IX (PpIX) photobleaching. A novel dosing approach was introduced in that we used a photobleaching percentage instead of a preset fluence. Data show similar total and maximum damage scores in high and low fluence rate groups. Photobleaching of PpIX in the low fluence rate groups shows a trend toward more efficient photobleaching. Results indicate that low fluence rate PDT is as effective as and more efficient than high fluence rate PDT in normal mouse skin. Low fluence rate PDT light protocols need to be explored in human studies in search for an effective and well‐tolerated treatment for actinic field cancerization.
Photocatalytic Inactivation Efficiency of Anatase Nano‐TiO2 Sol on the H9N2 Avian Influenza Virus
Authors: Cui Haixin , Jiang Jianfang , Gu Wei , Sun Changjiao , Wu Donglai , Yang Tao , Yang Guochen 
Published: June 2010

AbstractThis study was conducted to investigate efficiency of TiO2nanomaterial as a novel environment‐friendly disinfectant to control avian influenza (AI) by its photochemical sterilization ability. Anatase nano‐TiO2sol, a neutral, viscous aqueous colloid of 1.6% TiO2, was synthesized from peroxotitanic acid solution according to the Ichinose method. Transmission electron microscope images showed that the TiO2particles were spindle‐shaped with an average size of 50 nm. X‐ray diffraction patterns revealed that the crystal phase of TiO2particles was anatase type with photocatalytic effect. A photocatalytic film of nano‐TiO2sol was tested as a means of inactivating H9N2avian influenza virus (AIV). Inactivation capabilities were examined with 365 nm ultraviolet (UV) radiation under black light by adjusting the UV intensity, the UV irradiation time and the quantity of AIV. The titer change of AIV was determined by hemagglutination tests. Cytopathic effect of Madin Darby canine kidney (MDCK) cells was monitored by inverted fluorescence microscope. The results showed that anatase nano‐TiO2sol significantly inactivated AIV under UV irradiation of 365 nm. The inactivation of AIV viruses reached up to 100%. Therefore, anatase nano‐TiO2sol is a potentially environment‐friendly antivirus agent to prevent AI.
A New Nonconjugated Naphthalene Derivative ofMeso‐tetra‐(3‐hydroxy)‐phenyl‐porphyrin as a Potential Sensitizer for Photodynamic Therapy
Authors: Silva Pedro , Fonseca Sofia M. , Arranja Cláudia T. , Burrows Hugh D. , Urbano Ana M. , Sobral Abilio J. F. N. 
Published: June 2010

AbstractA new 5,10,15,20‐tetra‐(phenoxy‐3‐carbonyl‐1‐amino‐naphthyl)‐porphyrin was prepared by an isocyanate condensation reaction and its photophysical properties fully evaluated, both in terms of photostability and singlet oxygen production. It shows considerably enhanced photostability when compared with the parent 5,10,15,20‐tetra‐(3‐hydroxy‐phenyl)‐porphyrin, with the photodegradation quantum yields for T(NAF)PP and T(OH)PP being 4.65 × 10−4and 5.19 × 10−3, respectively. Its photodynamic effect in human carcinoma HT‐29 cells was evaluated. The new porphyrin showed good properties as a sensitizer in photodynamic therapy with anin vitrocytotoxicity IC50value of 6.80 μg mL−1for a 24 h incubation. In addition to the potential of this compound, the synthetic route used provides possibilities of extension to a wide range of new sensitizers.
Differential propensity in recognition of prepsychotic phenomena among psychiatrists, clinical psychologists and school counsellors
Authors: Liu Chen‐Chung , Chang Li‐Ren , Tseng Huai‐Hsuan , Lai Meng‐Chuan , Hwu Hai‐Gwo 
Published: June 2010

AbstractAim: The prodromal symptoms of schizophrenia are difficult to differentiate from other common psychiatric illnesses or stress reactions. Despite the development of new diagnostic instruments, non‐specificity and poor awareness of this clinical entity are still major barriers to early identification of individuals at risk for schizophrenia. This study was conducted to assess differences among three types of mental health professionals in the recognition of prepsychotic phenomena.Methods: A questionnaire was developed that presented 11 case vignettes. The vignettes represented a hypothetical gradient of clinical severity, including stress reactions; very early stage, intermediate‐risk stage and very high‐risk stage of the schizophrenia prodrome; and full‐blown psychosis. The questionnaire was completed by 57 psychiatrists, 44 clinical psychologists and 50 school counsellors. For each vignette, respondents indicated their top three choices among nine different diagnostic considerations.Results: As a group, psychiatrists were most likely to consider schizophrenia for all stages of clinical severity, whereas school counsellors were least likely to. Still, only about half of psychiatrists selected schizophrenia as their first choice for very high‐risk cases, and even fewer psychologists and counsellors did so. A proportion of school counsellors failed to recognize full‐blown psychosis. Despite the differential propensity in recognition of prepsychotic phenomena, a gradient in considering schizophrenia as a possible diagnosis across the stages of clinical severity was obvious.Conclusions: Psychiatrists, clinical psychologists and school counsellors all need further education, targeting their group‐specific proclivities, to improve their sensitivity and specificity in early identification of individuals at risk for schizophrenia.
Cognitive‐behaviour therapy for medication‐resistant positive symptoms in early psychosis: a case series
Authors: Erickson David H. 
Published: June 2010

AbstractIntroduction: Cognitive‐behaviour therapy (CBT) for psychosis reduces the severity of medication‐resistant positive symptoms in chronic schizophrenia, but its efficacy for early psychosis outpatients with a similar profile has not been established.Objective: This paper describes an uncontrolled evaluation of CBT, added to medication and comprehensive care in an early psychosis program, in a group of stable outpatients.Patients: The sample was drawn from 24 consecutive referrals. Fourteen were eligible, i.e. had positive symptom(s) and had been on the same medication regime for 3 months.Treatment: Patients received an average of 16 individual sessions with a senior psychologist.Measures: Symptom severity was assessed both by an independent rater, and by patient self‐report.Results: Eleven of 14 patients completed treatment. Both clinician and self‐report post‐treatment ratings of positive symptoms were significantly reduced following CBT. For positive symptom totals, effect sizes ranged from d = 1.0 to 1.3. Clinically significant changes were apparent in at least eight of 11 patients.Discussion: While case‐series studies have significant limitations, the large effect sizes described here suggest that CBT shows promise for effectiveness with early psychosis patients. A randomized trial is needed to establish both the effect size over and above a control condition, and the durability of gains of CBT for medication‐resistant symptoms in early psychosis.
Evolutionary response of landraces to climate change in centers of crop diversity
Authors: Mercer Kristin L. , Perales Hugo R. 
Published: June 2010

AbstractLandraces cultivated in centers of crop diversity result from past and contemporary patterns of natural and farmer‐mediated evolutionary forces. Successful in situ conservation of crop genetic resources depends on continuity of these evolutionary processes. Climate change is projected to affect agricultural production, yet analyses of impacts on in situ conservation of crop genetic diversity and farmers who conserve it have been absent. How will crop landraces respond to alterations in climate? We review the roles that phenotypic plasticity, evolution, and gene flow might play in sustaining production, although we might expect erosion of genetic diversity if landrace populations or entire races lose productivity. For example, highland maize landraces in southern Mexico do not express the plasticity necessary to sustain productivity under climate change, but may evolve in response to altered conditions. The outcome for any given crop in a given region will depend on the distribution of genetic variation that affects fitness and patterns of climate change. Understanding patterns of neutral and adaptive diversity from the population to the landscape scale is essential to clarify how landraces conserved in situ will continue to evolve and how to minimize genetic erosion of this essential natural resource.