bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urinary 8‐hydroxy‐2‘‐deoxyguanosine (8‐OHdG) Levels in Women with or without Gynecologic Cancer*
Authors: Yamamoto Takara , Hosokawa Ken‐ichi , Tamura Takaya , Kanno Hiroshi , Urabe Mamoru , Honjo Hideo 
Published: August 2010

AbstractObjective: To detect the level of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) which is an oxygen‐radical‐forming agent, in the urine of patients with (n = 18) or without (n = 10) carcinoma of the female genitalia. None of the patients had been receiving any treatment before their urinary 8‐OHdG levels were measured.Methods: Urinary 8‐OHdG was extracted by a solid‐phase technique, and its level was determined by high‐performance liquid chromatography (HPLC) with an electric chemical detector (ECD).Results: We determined that the urinary 8‐OHdG level decreased with as the age of the patient increased, and was extremely high in advanced cancer and recurrent cancer in a considerable number of patients. The urinary 8‐OHdG level (1,827 ± 1,500 pmol/kg/day, mean ± SEM) in 18 patients with carcinoma was significantly higher (p ≤ 0.05) than that (747 ± 425 pmol/kg/day) in 10 patients without carcinoma.Conclusion: These results suggest that it might be possible to determine the spread of cancer to some extent by determining a patient's urinary 8‐OHdG level.
Prenatal Diagnosis of an Extensive Haemangioma of the Fetal Leg: A Case Report
Authors: Raman S. , Ramanujam T. , Lim C. T. 
Published: August 2010

AbstractExtensive haemangioma with platelet consumption (Kasabach‐Merritt syndrome) is rare. The lesion is usually a single cutaneous cavernous haemangioma1similar to that found in our patient. Multiple superficial strawberry naevi were also seen all over the rest of the body. This condition was diagnosed antenatally in this patient with the use of colour Doppler. There is one recent report where the thrombocytopaenia was diagnosed by cordocentesis.2Unfortunately the baby developed heart failure with intractable coagulopathy and died 2 days later.
Outcome of Unplanned Vaginal Deliveries after Two Previous Caesarean Sections
Authors: Jamelle Raana N. 
Published: August 2010

AbstractOnce a caesarean section always a caesarean section may not stand true any more but twice a caesarean section always a caesarean section still stays put because of its high maternal and foetal complications. Jinnah Postgraduate Medical Centre is large tertiary care hospital and has a caesarean section rate of over 18%; 10 patients (3.9%) were picked up in a retrospective study who had vaginal delivery after 2 previous caesarean sections in 2 years. They were admitted late in labour. Only one patient had dehiscence of scar. The aim of the study was to evaluate the outcome and safety of vaginal deliveries after 2 previous caesarean sections even when the trial was not conducted at the hospital.
The Value of Human Growth Hormone as an Adjuvant for Ovarian Stimulation in a Human in vitro Fertilization Program
Authors: Wu Ming‐Yih , Chen Hsin‐Fu , Ho Hong‐Nerng , Chen Shee‐Uan , Chao Kuang‐Han , Huang Su‐Cheng , Lee Tzu‐Yao , Yang Yu‐Shih 
Published: August 2010

AbstractThe purpose of this study was to evaluate whether the combined treatment of growth hormone (GH) and gonadotropins can improve ovulation stimulation in previously poor responders. Twelve patients who, had suboptimal responses in previous in vitro fertilization cycle were enrolled. They underwent 1 cycle with gonadotropin‐releasing hormone analogue (GnRH‐a) and gonadotropins and another cycle with GnRH‐a, gonadotropins, and GH. Serum gonadotropins, insulin‐like growth factor‐1 (IGF‐1), and sex steroids, including estradiol (E2), progesterone (P4), testosterone, and androstenedione were measured on Day 2 and during ovulation induction. The serum IGF‐1 level was higher in the GH cycle. There were no significant differences in the levels of the serum luteinizing hormone, E2, P4, testosterone, and androstenedione between the 2 cycles, so was IGF‐1, E2 and P4 in follicular fluid. Co‐treatment with GH did not improve the ovarian response. However, the GH cycles had better performance in terms of the number of oocytes fertilized and the pregnancy rate.
Sexual Behaviour and Prevalence of HIV Antibodies in Transsexuals
Authors: Chew Stephen , Tham K. F. , Ratnam S. S. 
Published: August 2010

AbstractObjective: To present data on the social characteristics, sexual behaviour and prevalence of HIV antibodies in 277 transsexuals.Material and Methods: One hundred fifty‐four male and 123 female transsexuals requesting surgical gender reassignment at the National University Hospital, Singapore were interviewed using a standard questionnaire. Blood samples were also taken at booking and prior to surgery and tested for HIV antibodies using a commercial enzyme immunoassay.Results: The mean ages of the male and female transsexuals were 26.3 and 28.3 years respectively. The majority of the transsexuals were Singaporean Chinese and had at least a secondary school education. None of the female and 14 (9%) of the male transsexuals were engaged in prostitution. Significantly more female (48%) than male (10.4%) transsexuals were sexually inactive. The sexual behaviour and practices of the transsexuals are also discussed.Conclusions: Significantly more male transsexuals compared to the female transsexuals, were sexually active, had earlier sexual contact, engaged more often in anal intercourse, and had 7 or more sexual partners. However, none of our transsexuals were positive for HIV antibodies.
Incidence of Postnatal Depression in Malaysian Women
Authors: Kit Lee Kick , Janet Grace , Jegasothy Ravindran 
Published: August 2010

AbstractObjective: To determine the incidence of postnatal depression of Malaysias women at 6 week postpartum and a survey of their sociocultural practices.Methods: A hundred and fifty‐four women who were 6 weeks postpartum attending the postnatal clinic between May and July 1995 at Maternal and Child Health Clinic, Seremban, Malaysia.Maternal socio‐demography, depression by Edinburgh Postnatal Depression Scale (EPDS), postnatal care and practices e.g. pantang larang (prohibited behaviour and practices), diet and partnering were evaluated.Results: Postnatal depression was 3.9%. Indians had the highest rate at 8.5% as compared to Malays (3.0%) and none in Chinese (p < 0.05). There were no demographic differences in the study groups. Average score of EPDS was 4.05 which ranged from 0 to 20. During the confinement 85.7% of women took special diet; 64.3% followed pantang larang and 78.8% had someone to look after them.The incidence of postnatal depression is low in Malaysia at 3.9%. Majority of Malaysian women still observed the traditional postnatal beliefs and practices.
Importance of the Transitional Zone between the Cervical Stroma and the Parametrium in the Treatment of Cervical Carcinoma
Authors: Tabata Masaaki , Makinoda Satoru , Yamaguchi Tatsumi , Sakuragi Noriaki , Fujimoto Seiichiro 
Published: August 2010

AbstractObjectives: Parametrial invasion is an important risk factor in cervical carcinoma. Because the vessels of the parametrium start in the zone between the cervical compact stromal layer and the parametrium, which we have defined as the parametrial initial zone (PIZ) or transitional zone, the invasion of a carcinoma into this part of the cervix is also important. Our objectives in this study were find a characteristic index of the transitional zone and to clarify the relationship between a transitional‐zone invasion and the prognosis in a case.Methods: Thirty‐three cases of carcinoma in situ were available to use for the morphological examination of the cervix. The cervix was divided into 8–12 sections. In each section, the outer diameters of the short axis of the arteries were measured with a light microscope and a micrometer. Using the arterial diameter as the characteristic index of the transitional zone, we performed epidemiological studies on 312 patients with clinical Stage Ib‐III squamous‐cell carcinoma of uterine cervix.Results: The arteries with an axis exceeding 300 μm were concentrated in the transitional zone at a rate of 94.6%. Therefore, arteries of this size are used as the characteristic index of the transitional zone. Patients with invasion to transitional zone only had lymph node metastasis at the rate of 28.1%, compared with 0% for patients who had no permeation to the zone (p < 0.001). The 5‐year survival rate of patients with invasion to the transitional zone only was 87.3%, which is significantly lower than those without invasion (99.2%) (p < 0.01).Conclusions: Measuring the short axis (300 μm ≤) of the artery is the best method by which to pinpoint the transitional zone. The invasion of a carcinoma into the transitional zone in the cervix should be treated as a parametrial involvement.
Effect of Population Density on the Early Post‐Implantation Mouse Embryo Growth in vitro
Authors: Kang Byung Moon , Kim Chung Hoon , Chang Yoon Seok , Mok Jung Eun 
Published: August 2010

AbstractObjective: To investigate the relationship between embryo population density and embryo development in vitro.Methods: Swiss Webster albino mice were used and blastocysts were flushed from the uterine horns. Various numbers of blastocysts were randomly assigned to separate 35 mm dishes and cultured for 9 days.Results: The effect of duration of culture to the mean success rates was different as the number of embryos in the dish was changed. In early egg cylinder (EEC) stage; the mean success rate was a flat function of the number of embryos. But the mean success rate was a decreasing function in late egg cylinder (LEG) stage and the decreasing rate was faster in early somite (ES) stage. Interestingly, the mean success rate to ES stage was nearly constant when more than 10 embryos were cultured in one dish.Conclusion: The success rate to each developmental stage in vitro decreased as the number of embryos in the dish and the duration of culture increased.
Effects of All‐trans Retinoic Acid on Choriocarcinoma Cells in vitro*
Authors: Yamada Satoru , Okamoto Tomomitsu , Nakanishi Toru , Nomura Seiji , Tomoda Yutaka 
Published: August 2010

AbstractObjective: To determine the activities of all‐trans retinoic acid (RA) on choriocarcinoma cells in vitro.Methods: The antiproliferative effect of all‐trans RA on 4 choriocarcinoma cell lines was measured by the MTT assay. The effect of all‐trans RA combined with methotrexate or actinomycin‐D was then examined. The effect of all‐trans RA on hCG secretion was also studied. The gene expression of retinoic acid receptors (RARs) was examined by RT‐PCR.Results: All‐trans RA inhibited cell proliferation dose‐ and time‐dependently; a 6‐day exposure to 1 μM all‐trans RA suppressed the cell growth by 67.8%‐82.0% compared to the controls. An enhanced effect was observed in the combined administration of all‐trans RA and methotrexate or actinomycin‐D. The secretion of hCG increased 4‐fold to 9‐fold by the addition of 1 μm all‐trans RA. RARs genes were expressed in all cell lines.Conclusion: The anticancer activity presented here appears to warrant further evaluation of all‐trans RA as adjuvant therapy for choriocarcinoma.
Immunohistochemical Studies on Matrix Metalloproteinase‐9 (MMP‐9) and Type‐IV Collagen in Endometrial Carcinoma
Authors: Inoue Yoshiki , Abe Kunio , Obata Koushiro , Yoshioka Tadaaki , Ohmura Gen , Doh Kunihiko , Yamamoto Kaichiro , Hoshiai Hiroshi , Noda Kiichiro 
Published: August 2010

AbstractImmunohistochemical staining of MMP‐9 and the type‐IV collagen was performed on paraffin sections of endometrial carcinoma. Immunostaining in 129 cases of endometrial cancer detected MMP‐9 in 19.0% of the cases. MMP‐9 positive was shown in 30% of the cases with vessel invasion, and in 12.7% of the cases without vessell invasion (p < 0.05). MMP‐9 showed positive in many cases with poor differentiation and lymph node metastasis, but still failed to achieve statistical significance. MMP‐9 staining did not correlate with disease outcomes. We can not clarify that MMP‐9 is associated with tumor‐cell invasion and metastasis. Type‐IV collagen deposition at the tumor‐stromal border was studied in 58 cases of endometrial carcinoma in which disruptions were seen in varying degrees. The type‐IV collagen in the primary lesion decreased as the differentiation decreased. Even in the lymph node metastasis lesions, the type‐IV collagen was stained and was almost in agreement with the primary lesions. In the primary lesions, there was no relationship between MMP‐9 staining and the type‐IV collagen. It was suggested that the type‐IV collagen observed in endometrial carcinoma was more concerned with the differentiation of the tumor than with the degradation by MMP‐9.
The Detection of Right‐Sided Congenital Diaphragmatic Hernia in Monozygotic Twins on Prenatal Ultrasonography
Authors: Chao An‐Shine , Cheng Po‐Jen , Hsueh Chuen , Soong Yung‐Kuei 
Published: August 2010

AbstractThe diagnosis of a pair of monozygotic twins with right‐sided diaphragmatic hernia under ultrasound is described. Aspects of heredity, diagnosis and management are discussed.
Preinduction Cervical Ripening: Prostaglandin E2 Gel vs Hygroscopic Mechanical Dilator
Authors: Chua S. , Arulkumaran S. , Vanaja K. , Ratnam S. S. 
Published: August 2010

AbstractObjectives: To evaluate the efficacy and safety of hygroscopic mechanical dilators (Dilapan™) for ripening the pregnant cervix prior to induction of labour at or near term and to compare it with an intracervical PGE2 gel (Prepidil™).Methods: One hundred and eighty‐five women (69 nulliparae, 116 multiparae) at term with singleton pregnancies in cephalic presentation, who were scheduled for induction of labour in the labour ward at the National University Hospital, but had an unfavourable cervical score were randomized into 2 groups by random number table. In group 1 (Prepidil), 0.5 mg of PGE2 in 2.5 ml of triacetin gel was inserted into the endocervical canal. In women in group 2 (Dilapan) upto a maximum of 4 hygroscopic dilators were placed in the endocervical canal. If labour did not ensue at the end of 12 hours of ripening, the cervical score was assessed, amniotomy was performed and oxytocin commenced. Neonatal and obstetric outcome was compared, statistical analysis performed using Chi‐square, and t‐tests.Results: Significantly more women in the group who received Dilapan for cervical ripening required amniotomy and oxytocin for induction of labour > 12 hours after priming compared with the group who received Prepidil (p < 0.001). Operative delivery for no progress and fetal distress respectively was similar in the 2 groups. The number of cases of hyperstimulation were higher in the Prepidil group but did not result in an increased incidence of operative deliveries for fetal distress. There was one neonatal death and one case of neonatal sepsis in the Dilapan group. Uterine rupture occurred in 1 woman who received Prepidil.Conclusion: Dilapan, a mechanical method of cervical ripening is as effective as the more widely accepted mode of ripening with an endocervical PGE2 gel in achieving vaginal delivery. Dilapan would be useful for cervical priming prior to induction of labour in places where prostaglandins are not available because of cost and the need for a cold chain.
Risk Factors Predictive of Para‐Aortic Lymph Node Metastasis in Endometrial Carcinomas*
Authors: Yokoyama Yoshihito , Maruyama Hidetoshi , Sato Shigemi , Saito Yoshiharu 
Published: August 2010

AbstractObjective: To identify risk factors predictive of para‐aortic lymph node (PAN); metastasis in endometrial carcinomas.Methods: Sixty patients with endometrial carcinomas Stage I to III (FIGO, 1988) who each underwent a complete pelvic and para‐aortic lymphadenectomy with a semiradical or radical hysterectomy, bilateral salpingo‐oophorectomy, between April 1988 and March 1996, were included in this study. The relationship between PAN metastasis and clinico‐pathological factors such as histological type, grade, depth of myometrial invasion (MI), vascular space involvement (VSI), cervical invasion (CI), peritoneal cytology, tumor size, pelvic lymph node (PLN) metastasis, and glutathione S‐transferase π (GST‐π) expression was examined using univariate and multivariate analysis.Results: Seven variables — G3 grade, more than one‐half MI, positive VSI, positive CI, tumor size of more than 2 cm in diameter, positive PLN metastasis, and positive GST‐π — were significantly correlated with PAN metastasis using univariate analysis. Multivariate analysis revealed that of the above 7 variables, 3 were significantly and independently correlated with PAN metastasis: more than one‐half MI, positive PLN, and positive GST‐π. The relative risk of a patient with these 3 factors having PAN metastasis was 18.0 times greater than the risk for a patient without them.Conclusion: These variables — More than one‐half MI, positive PLN, and positive GST‐π — were significantly related to PAN metastasis.
The Behavior of Endometrial Hyperplasia: A Prospective Study
Authors: Terakawa Naoki , Kigawa Junzo , Taketani Yuji , Yoshikawa Hiroyuki , Yajima Akira , Noda Kiichiro , Okada Hiroji , Kato Junzo , Yakushiji Michiaki , Tanizawa Osamu , Fujimoto Seiichiro , Nozawa Shiro , Takahashi Takeshi , Hasumi Katsuhiko , Furuhashi Nobuyuki , Aono Toshihiro , Sakamoto Atsuhiko , Furusato Masakuni ,   Endometrial Hyperplasia Study Group
Published: August 2010

AbstractObjective: To clarify the behavior of endometrial hyperplasia in a prospective study.Method: Fifty‐one patients with endometrial hyperplasia were followed up for 6 months. Samples of endometrial tissues were taken by uterine endometrial biopsy every 4 weeks during the first 3 months and at the end of follow‐up.Results:/ In 69% (35/51) of the patients histological picture of the endometrium became normal during the observation period. The lesions persisted in 17% (6/35) of the patients with simple hyperplasia, in 25% (1/4) of those with complex hyperplasia, in 14% (1/7) of those with simple atypical hyperplasia, and in 80% (4/5) of the patients with complex atypical hyperplasia. In the remaining 3 patients with simple hyperplasia, the lesions progressed to complex atypical hyperplasia by the end of follow‐up, after showing a normal endometrium.Conclusion: Most cases of endometrial hyperplasia, except for complex atypical hyperplasia, disappeared spontaneously within a short period of time.
Outcome of Abruptio Placentae in Normotensive and Hypertensive Patients in Aga Khan University Hospital, Pakistan
Authors: Munim Shama , Chaudhury Nasreen , Jamal Khalid , Khan Fida Ali 
Published: August 2010

AbstractThe aim of our study was to compare the perinatal and maternal outcome in hypertensive women experiencing abruptio placentae with that of normotensive women. We hypothesized that hypertensive women experiencing abruptio had a less favorable outcome than the normotensive women. Ours was a retrospective cohort study, in which the outcome of 33 hypertensive women with abruptio was compared with 138 normotensive women experiencing abruptio placentae. Our results indicate that although higher number of hypertensive women with abruptio had a past history of hypertension and were more likely to have diabetes (p = 0.05) there was no difference found in the grades of abruption or in any other antenatal complications between the 2 groups. The hypertensive women were also more likely to undergo cesarean section. We did not find any difference in the neonatal outcome. Therefore, we conclude that there is no difference in the maternal and perinatal outcome between the hypertensive and normotensive women experiencing abruptio.
Puerperal Inversion of the Uterus in Nepal: Case Reports and Review of Literature
Authors: Dali Sanu Maiya , Rajbhandari S. , Shrestha S. 
Published: August 2010

AbstractRetrospective study of 6 cases of puerperal inversion of the uterus is being presented from 1975 to 1995 and a review of literature for 20 years of the period 1975–1995 has been summarised. In the present series, one case with acute puerperal inversion of uterus were treated by manual reposition, 2 cases of chronic puerperal inversion of uterus was treated surgically by Kustner's vaginal approach. Two cases with subacute puerperal inversion of uterus, 1 case of chronic puerperal inversion were treated by Haultain and Huntington method. Out of 241 cases of uterine inversion obtained from review of literature for last 20 years, 229 (95%) constituted puerperal and 12 (5%) were non puerperal inversions. Among puerperal inversions, 191 (83.4%) cases were of acute type and only 6 (2.62%) cases were of subacute variety. The chronic puerperal inversion constituted 32 (13.9%). Out of 63 cases of uterine inversions in India, maternal deaths were reported as 6 (9.5%) but there was no maternal death in the present series.
Hypersensitivity Reactions to Cisplatin following Multiple Uncomplicated Courses: A Report on Two Cases
Authors: Onoyama Yoshimichi , Umezu Takashi , Kuriaki Yumiko , Honda Naotoshi 
Published: August 2010

AbstractTwo patients with ovarian cancer who had received multiple courses of cisplatin without complications experienced hypersensitivity reactions to cisplatin: one, involving intrahepatic artery infusion, manifested general erythema, dyspnea, and hypotension; the other, involving intravenous infusion, manifested abdominal pain, general erythema, and fever. When platinum‐containing agents are administered, patients should be closely monitored for hypersensitivity reactions, even in previously uncomplicated cases.
A Comparison of Intravaginal Misoprostol and Intracervical Prostaglandin E2 Gel for Ripening of Unfavorable Cervix and Labor Induction
Authors: Herabutya Yongyoth , O‐Prasertsawat Pratak , Pokpirom Jareeporn 
Published: August 2010

AbstractObjective: To study the effectiveness of single application of intravaginal misoprostol versus intracervical prostaglandin E2 gel for ripening the unfavorable cervix and labor induction.Method: One hundred and ten patients with indications for induction of labor with unfavorable cervices were randomized to receive either 100 microgram tablets of misoprostol placed in the posterior vaginal fornix or prostaglandin E2 1.5 mg in gel placed into the endocervix. Those, who were not in active labor after 24 hours, had labor induced with amniotomy and oxytocin.Results: Among 110 patients recruited, 60 received misoprostol and 50 received prostaglandin E2 gel. The average interval from start of induction to vaginal delivery was 19.14 ± 10.64 hours in misoprostol group and 21.37 ± 13.09 hours in the prostaglandin E2 group (p = 0.33). Five patients (8%) in the misoprostol group had induction of labor after 24 hours of the treatment compared with 13 patients (26%) in the PGE2 group. The difference was significant (p = 0.03). Oxytocin augmentation was 35% in the misoprostol group and 34% in the prostaglandin E2 group (p = 0.86). There were no significant differences between routes of delivery. Nineteen patients (31%) in misoprostol group and 16 patients (32%) in the PGE2 gel group had cesarean deliveries. There was one case (1.7%) of uterine hyperstimulation in the misoprostol group and none in the PGE2 gel group. There were no significant difference in Apgar scores < 7 at 1 and 5 minutes, or admission to the neonatal intensive care unit between the 2 groups.Conclusion: Vaginal misoprostol is an effective agent for cervical ripening and induction of labor. Complications associated with prostaglandin administration were not statistically different between the 2 groups, but hyperstimulation occurred more in misoprostol group.