bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypothyroidism in patients with renal cell carcinoma
Authors: Schmidinger Manuela , Vogl Ursula M. , Bojic Marija , Lamm Wolfgang , Heinzl Harald , Haitel Andrea , Clodi Martin , Kramer Gero , Zielinski Christoph C. 
Published: September 2010

AbstractBACKGROUND:Sunitinib and sorafenib are tyrosine kinase inhibitors that have important antitumor activity in metastatic renal cell carcinoma (mRCC). Hypothyroidism constitutes a commonly reported side effect of both drugs, and particularly of sunitinib. The objective of this analysis was to investigate whether the occurrence of hypothyroidism during treatment with sunitinib and sorafenib affects the outcome of patients with mRCC.METHODS:Eighty‐seven consecutive patients with mRCC who were to receive treatment with sunitinib or sorafenib were included in a prospective analysis. Thyroid function was assessed in each patient every 4 weeks during the first 2 months of treatment and every 2 to 4 months thereafter. Assessment included serum levels of thyroid‐stimulating hormone (TSH), tri‐iodthyronine (T3), and thyroxine (T4). Subclinical hypothyroidism was defined as an increase in TSH above the upper limit of normal (>3.77 μM/mL) with normal T3 and T4 levels.RESULTS:Subclinical hypothyroidism was evident in 5 patients at baseline and occurred in 30 patients (36.1%) within the first 2 months after treatment initiation. There was a statistically significant correlation between the occurrence of subclinical hypothyroidism during treatment and the rate of objective remission (hypothyroid patients vs euthyroid patients: 28.3% vs 3.3%, respectively; P < .001) and the median duration of survival (not reached vs 13.9 months, respectively; hazard ratio, 0.35; 95% confidence interval, 0.14‐0.85; P = .016). In multivariate analysis, the development of subclinical hypothyroidism was identified as an independent predictor of survival (hazard ratio, 0.31; P = .014).CONCLUSIONS:The current results indicated that hypothyroidism may serve as a predictive marker of treatment outcome in patients with mRCC. Thus, the interpretation of hypothyroidism during treatment with sunitinib and sorafenib as an unwanted side effect should be reconsidered. Cancer 2011. © 2010 American Cancer Society.
Use of booster inoculations to sustain the clinical effect of an adjuvant breast cancer vaccine
Authors: Holmes Jarrod P. , Clifton Guy T. , Patil Ritesh , Benavides Linda C. , Gates Jeremy D. , Stojadinovic Alexander , Mittendorf Elizabeth A. , Ponniah Sathibalan , Peoples George E. 
Published: September 2010

AbstractBACKGROUND:The authors are conducting clinical trials of the HER‐2/neu E75‐peptide vaccine in clinically disease‐free breast cancer (BC) patients. Their phase 1‐2 trials revealed that the E75 + granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) vaccine is safe and effective in stimulating clonal expansion of E75‐specific CD8+ T cells. They assessed the need for and response to a booster after completion of primary vaccination series.METHODS:BC patients enrolled in the E75 vaccine trials who were ≥6 months from completion of their primary vaccination series were offered boosters with E75 + GM‐CSF. Patients were monitored for toxicity. E75‐specific CD8+ T cells were quantified using the human leukocyte antigen‐A2:immunoglobulin G dimer before and after boosting.RESULTS:Fifty‐three patients received the vaccine booster. Median time from primary vaccination series was 9 months (range, 6‐35 months), and median residual E75‐specific immunity was 0.70% (range, 0‐3.49%) CD8+ lymphocytes. Elevated residual immunity (ERI) (CD8+ E75‐specific T cells >0.5%) was seen in 94.4% of patients at 6 months from primary vaccination series versus 48% of patients at >6 months (P = .002). The booster was well tolerated, with only grade 1 and 2 toxicity observed. Local reactions were more robust in patients receiving the booster at 6 months from primary vaccination series compared with those at >6 months (99.4 ± 6.1 mm vs 81.8 ± 4.1 mm, P = .01). In patients lacking ERI, 85% had increased ERI after vaccination (P = .0014).CONCLUSIONS:The HER‐2/neu E75 peptide vaccine E75 stimulates specific immunity in disease‐free BC patients. However, immunity wanes with time. A vaccine booster is safe and effective in stimulating E75‐specific immunity in those patients without ERI. These results suggest that the booster may be most effective at 6 months after completion of the primary vaccination series. Cancer 2011. Published 2010 by the American Cancer Society.
Flow cytometric detection of degranulated basophils in chronic myeloid leukemia in accelerated phase
Authors: Stacchini Alessandra , Demurtas Anna , Godio Laura 
Published: September 2010

AbstractWe report a rare case of chronic myeloid leukemia in accelerated phase with basophilic transformation, in which basophils exceeding 70%, were detectable only by flow cytometry because of their morphologic atypicality and degranulation. © 2010 Clinical Cytometry Society.
Electroanalysis of trimethoprim on metalloporphyrin incorporated glassy carbon electrode
Authors: Rajith Leena , Kumar Krishnapillai Girish 
Published: September 2010

AbstractTrimethoprim (TMP) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections. It belongs to the class of chemotherapeutic agents known as dihydrofolate reductase inhibitors. Its use is associated with idiosyncratic reactions, including liver toxicity and agranulocytosis. In order to determine TMP electrochemically, a metalloporphyrin modified glassy carbon electrode was prepared by coating [5,10,15,20‐ tetrakis(4‐methoxyphenyl) porphyrinato]Mn (III)chloride (TMOPPMn(III)Cl) solution on the surface of the electrode. The electrochemical behaviour of TMP in Phosphate buffer solution (PBS) on TMOPPMn(III)Cl modified glassy carbon electrode (TMOPPMn(III)Cl/GCE) was explored using differential pulse voltammetry (DPV). The voltammograms showed enhanced oxidation response at the TMOPPMn (III)Cl/GCE with respect to the bare GCE for TMP, attributable to the electrocatalytic activity of TMOPPMn(III)Cl. Electrochemical parameters of the oxidation of TMP on the modified electrode were analyzed. The electro‐oxidation of TMP was found to be irreversible, pH dependent and adsorption controlled on the modified electrode. It is found that the oxidation peak current is proportional to the concentration of TMP over the range 6 × 10−8 − 1 × 10−6 M with a very low detection limit of 3 × 10−9 M at 2 min open circuit accumulation. The repeatability expressed as relative standard deviation (RSD) for n = 9 was 3.2% and the operational stability was found to be 20 days. Another striking feature is that equimolar concentration of sulfamethoxazole did not interfere in the determination of TMP. Applicability to assay the drug in urine and tablet samples has also been studied. Copyright © 2010 John Wiley & Sons, Ltd.
Synthesis, Characterization and Application of Nitrile‐Ligated Zinc(II) Complexes Incorporating (Fluoroalkoxy)aluminates
Authors: Li Yang , Yeong Hui Yee , Herdtweck Eberhardt , Voit Brigitte , Kühn Fritz E. 
Published: September 2010

AbstractNitrile‐ligated zinc(II) complexes incorporating aluminum‐based weakly coordinating anions (WCAs) have been successfully prepared and fully characterized. An X‐ray crystal structure proves both the octahedral symmetry of the zinc(II) cation having six nitrile ligands and the non‐coordinating nature of the anion. Similar to complexes bearing boran‐based WCAs, the compounds described here can be applied to polymerize isobutylene at room temperature resulting in polyisobutylene with a high content of exo double bonds.
MMX Chains and Molecular Species Containing Rh2n+ (n = 4, 5, and 6) Units: Electrical Conductivity in Crystal Phase of MMX Polymers
Authors: Amo‐Ochoa Pilar , Jiménez‐Aparicio Reyes , Torres M. Rosario , Urbanos Francisco A. , Gallego A. , Gómez‐García Carlos J. 
Published: September 2010

AbstractThe control of the experimental conditions in the reaction of Rh2(O2CCH3)4 with halides allows the isolation of the noveldirhodium complexes Kx[Rh2X(O2CCH3)4]x·4xH2O (X = Br, 1·4H2O and I, 2·4H2O) [Rh2(O2CCH3)4Cl]x·xH2O (3·H2O), [Rh2(O2CCH3)Cl]x·4xH2O (3·4H2O), and [Rh2(O2CCH3)4I2]·4H2O (4·4H2O) containing Rh2n+ (n = 4, 5 and 6) units. The X‐ray structure determination of compounds 1–4 reveals the presence of dirhodium units in different oxidation states. The polyanionic complexes 1·4H2O and 2·4H2O containing Rh24+ units give zig‐zag chains. In contrast, the partially oxidized complexes 3·H2O and 3·4H2O containing Rh25+ units are linked by chloride ligands forming linear chains. The first tetracarboxylatodirhodium(III) compound 4·4H2O is also described. Its structure consists of discrete binuclear [Rh2(O2CCH3)4]2+ units with both axial positions occupied by iodide ligands. The very simple synthetic procedures presented here to achieve the partial or complete oxidation of the dirhodium(II) precursors open new perspectives in dirhodium complexes containing different oxidation states and in their potential applications in the construction of molecular devices. The electrical characterization of the polymer chains confirms conductivity in crystal phase. In addition, isolation of 1·4H2O and 2·4H2O on mica and morphological characterization of individual chains by atomic‐force microscopy have been achieved.
Coordination of Coenzyme M and Its Derivatives on NiII(tetraazacycle) Complexes: A Model for the Active Site of Methyl Coenzyme M Reductase
Authors: Nishigaki Jun‐ichi , Matsumoto Tsuyoshi , Tatsumi Kazuyuki 
Published: September 2010

AbstractA series of tetraazamacrocyclic nickel(II) complexes coordinated by methyl coenzyme M (MeSCoM), coenzyme M (HSCoM), and 3‐methylthiopropionate (Metp) have been synthesized as structural models of the active site of methyl coenzyme M reductase in the oxidized MCRsilent state. They include RSRS‐[Ni(tmc)(L)](OTf) {L = MeSCoM (2), HSCoM (4), and Metp (5)} (tmc = 1,4,8,11‐tetramethyl‐1,4,8,11‐tetraazacyclotetradecane) and [Ni(pyc)(L)](OTf) {L = MeSCoM (6), HSCoM (7), Metp (8), pyc = 5‐oxo‐7‐(2‐pyridyl)‐1,4,8,11‐tetraazacyclotetradecane}. The X‐ray crystal analysis revealed that MeSCoM, HSCoM, and Metp are bound to Ni in an η1 manner through interactions with one O atom of each ligand. The tmc complexes assume a pentacoordinate geometry, which is in between a square pyramid and a trigonal bipyramid, while the pyc complexes are octahedral with coordination of the pendant pyridine at the site trans to the sulfonate or carboxylate ligand.
Crystallization‐Driven Asymmetric Synthesis of Pyridine‐β‐nitroalcohols via Discovery‐Oriented Self‐Resolution of a Dynamic System
Authors: Angelin Marcus , Vongvilai Pornrapee , Fischer Andreas , Ramström Olof 
Published: September 2010

AbstractThe study of dynamic nitroaldol systems aided the discovery of a diastereoselective crystallization process through amplification of 2‐nitro‐1‐(pyridine‐4‐yl)propan‐1‐ol. The phenomenon was further developed into an effective procedure for asymmetic synthesis of pyridine‐nitroalcohols and several substrates were screened to this end. These results demonstrate how work with larger dynamic systems facilitates and increases the likelihood of serendipitous discoveries.
A review on cyclodextrin encapsulation of essential oils and volatiles
Authors: Marques Helena Ma Cabral 
Published: September 2010

AbstractCyclodextrins (CyDs) are cyclic carbohydrates derived from starch. The parent CyDs contain six, seven and eight glucopyranose units and are referred as α‐, β‐ and γ‐CyD, respectively. The most important property of the CyDs is the ability to establish specific interactions – molecular encapsulation – with various types of molecules through the formation of non‐covalently bonded entities, either in the solid phase or in aqueous solution. These nano‐encapsulating agents may form inclusion complexes with essential oils and volatiles, or their components, in order to improve their characteristics, such as transformation of liquid compounds into crystalline form; masking unpleasant smells and tastes of some compounds; improving the physical and/or chemical stability; and stabilizing volatile compounds by reducing or eliminating any losses through evaporation. Complexation has been used to avoid the destruction of certain flavours by processing or, on storage, allowing the use of minor amounts of flavours. The guest molecule is released in the warm moisture of the mouth. Examples are spices, essential oils of vegetable origin and plant flavours, chamomile oil and extract, eucalyptus oil, fennel oil, lemon oil, onion and garlic oil, camphor, menthol, thymol, etc. There are several methods for the preparation of inclusion complexes; kneading, co‐precipitation, freeze‐drying and spray‐drying the most commonly used. Evidence for a guest inclusion into the apolar CyD cavity may be proved by various analytical techniques, including NMR spectroscopy, UV–visible absorption spectroscopy, optical rotatory dispersion and circular dichroism, fluorescence, infrared/FT‐IR spectroscopy, thermo‐analysis, TLC, mass spectromety, and powder X‐ray diffractometry. Copyright © 2010 John Wiley & Sons, Ltd.
Network interactions explain effective encoding in the context of medial temporal damage in MCI
Authors: Protzner Andrea B. , Mandzia Jennifer L. , Black Sandra E. , McAndrews Mary Pat 
Published: September 2010

AbstractSelective dysfunction in the medial temporal lobe (MTL) in amnestic mild cognitive impairment (MCI) results in a relatively circumscribed impairment in episodic memory. Previously, we found that activation extent in MTL during encoding correlated with subsequent recognition (hit rate) in controls but not in MCI patients (Mandzia et al. [2009]: Neurobiol Aging 30:717–730). Here, we examined whether functional connectivity amongst MTL and cortical regions might better explain differences in subsequent recognition success. Participants underwent fMRI scanning during picture encoding, and multivariate analysis was used to characterize the relationship between network activations and recognition. Both patients and controls activated a canonical MTL encoding network. However, this network correlated with hit rate only for controls. In MCI patients, recognition variability was best explained by the engagement of an additional network including BA 20. We propose that this pattern represents functional reorganization caused by reduced efficiency in the MTL network. Our findings suggest that understanding brain‐behavior relationships in neurological disorders requires examination of large‐scale networks, even when dysfunction is relatively focal as in MCI. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Association between reward‐related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype
Authors: Hahn Tim , Heinzel Sebastian , Dresler Thomas , Plichta Michael M. , Renner Tobias J. , Markulin Falko , Jakob Peter M. , Lesch Klaus‐Peter , Fallgatter Andreas J. 
Published: September 2010

AbstractThe impact of individual differences on human reward processing has been a focus of research in recent years, particularly, as they are associated with a variety of neuropsychiatric diseases including addiction and attention‐deficit/hyperactivity disorder. Studies exploring the neural basis of individual differences in reward sensitivity have consistently implicated the ventral striatum (VS) as a core component of the human reward system. However, the mechanisms of dopaminergic neurotransmission underlying ventral striatal activation as well as trait reward sensitivity remain speculative. We addressed this issue by investigating the triadic interplay between VS reactivity during reward anticipation using functional magnetic resonance imaging, trait reward sensitivity, and dopamine (DA) transporter genotype (40‐bp 3′VNTR of DAT, SLC6A3) affecting synaptic DA neurotransmission. Our results show that DAT variation moderates the association between VS‐reactivity and trait reward sensitivity. Specifically, homozygote carriers of the DAT 10‐repeat allele exhibit a strong positive correlation between reward sensitivity and reward‐related VS activity whereas this relationship is absent in the DAT 9‐repeat allele carriers. We discuss the possibility that this moderation of VS‐trait relation might arise from DAT‐dependent differences in DA availability affecting synaptic plasticity within the VS. Generally, studying the impact of dopaminergic gene variations on the relation between reward‐related brain activity and trait reward sensitivity might facilitate the investigation of complex mechanisms underlying disorders linked to dysregulation of DA neurotransmission. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Within‐limb somatotopic representation of acute muscle pain in the human contralateral dorsal posterior insula
Authors: Henderson Luke A. , Rubin Troy K. , Macefield Vaughan G. 
Published: September 2010

AbstractIt is well established that the insular cortex processes noxious information. We have previously shown that noxious inputs from the arm and leg are coarsely organized somatotopically within the dorsal posterior insula. The same has been shown for inputs from C tactile afferents, which mediate affective touch, and it has been suggested that the insula may be responsible for the localization of some somatosensory stimuli. Knowing the degree of spatial detail may have significant implications for the potential role of the dorsal posterior insula in the processing of noxious stimuli. Using high‐resolution functional magnetic resonance imaging (fMRI), we compared insula activation patterns in 13 subjects during muscle pain induced by injection of hypertonic saline (5%) into three muscles within the same limb: shoulder (deltoid), forearm (flexor carpi radialis), and hand (first dorsal interosseous). Mapping the maximally activated voxels within the contralateral dorsal posterior insula in each individual subject during each pain stimulus revealed a clear somatotopy of activation within the contralateral dorsal posterior insula. Shoulder pain was represented anterior to forearm pain and medial to hand pain. This fine somatotopic organization may be crucial for pain localization or other aspects of the pain experience that differ depending on stimulation site. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
THE USE OF HYDRAULIC MODELS TO OPTIMIZE THE REHABILITATION OF AN OPEN CHANNEL IRRIGATION SYSTEM: THE EXAMPLE OF THE SENEGAL RIVER DELTA IRRIGATION SYSTEM
Authors: Bouisse Thomas , Baume Jean‐Pierre , Gassama Mahamoud 
Published: September 2010

ABSTRACTFor more than 30 years, important investments have been made in hydro‐agricultural schemes in the Senegal River Delta. Indeed, the river's distributaries form a complex network of natural side channels with a high potential in terms of land suitable for irrigation. However, the current configuration of these channels and the lack of maintenance prevent this feeder system from conveying the flows required to meet the region's agricultural production potential. Consequently their rehabilitation has started. This takes into account the future water demand, the network's geometrical characteristics, the actual practice of irrigation, as well as the type of control used for managing the system, and has led to the use of a mathematical model for design purposes: the Simulation of Irrigation Canals (SIC) software, developed by Cemagref. The SIC software has been chosen because it accommodates the simulation of automatic gates and performs transient state runs particularly well. Steady‐state runs do not take into account decisive factors like diurnal irrigation or the significant storage capacity of the system, and would lead to a flawed design of the system. This article illustrates the advantages of using the transient regime for the design of a networked feeder system with substantial storage capacity. Copyright © 2010 John Wiley & Sons, Ltd.
Latex use as an occlusive membrane for guided bone regeneration
Authors: Ereno Cibele , Guimarães Sérgio A. Catanzaro , Pasetto Silvana , Herculano Rondinelli Donizetti , Silva Cecília Pereira , Graeff Carlos F. O. , Tavano Orivaldo , Baffa Oswaldo , Kinoshita Angela 
Published: September 2010

AbstractLatex extracted from Hevea brasiliensis was used as an occlusive membrane for guided bone regeneration. Twenty‐four rabbits were divided in two groups: treated and control group. Critical size bone defects (2 cm × 1 cm) were surgically made in the rabbit calvarium. Two latex membranes were implanted in each animal of the treated group, whereas the control defect was filled only with autogenous blood clot. After 15, 30, 60, and 120 days, animals from each group were euthanized, and the samples with regenerated bone were removed. No signs of allergy or rejection were noticed around the calvarial bone defect of the treated group. In the histological analysis, no foreign body inflammatory reaction was observed in the adjacent tissues in contact with the membranes demonstrating that latex can be used at injured sites as an aid in the healing process. Histological analysis, digital radiography, and electron spin resonance were used to evaluate the progress of bone repair. The results show significant differences between groups (p < 0.05) suggesting that latex membranes accelerates healing in critical bone defects. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.
In vivo behavior of trimethylene carbonate and ε‐caprolactone‐based (co)polymer networks: Degradation and tissue response
Authors: Bat Erhan , Plantinga Josée A. , Harmsen Martin C. , van Luyn Marja J. A. , Feijen Jan , Grijpma Dirk W. 
Published: September 2010

AbstractThe in vivo erosion behavior of crosslinked (co)polymers based on trimethylene carbonate (TMC) and ε‐caprolactone (CL) was investigated. High molecular weight poly(trimethylene carbonate) (PTMC) homopolymer‐ and copolymer films were crosslinked by gamma irradiation. To adjust the in vivo erosion rate of the (co)polymer films, both the irradiation dose (25, 50, or 100 kGy) for PTMC and composition (100–70 mol % TMC) at a constant irradiation dose of 25 kGy were varied. After subcutaneous implantation of irradiated films in rats, their in vivo behavior was evaluated qualitatively and quantitatively. When the irradiation dose for PTMC was increased from 25 to 100 kGy, the erosion rate of nonextracted PTMC films (determined at day 5) decreased from 39.7 ± 16.0 μm day−1 to 15.1 ± 2.5 μm day−1, and the number of lymphocytes in the tissue surrounding the films decreased from 235 ± 114 cells mm−2 to 64 ± 33 cells mm−2. The number of macrophages and giant cells at the tissue–polymer interface also decreased with increasing irradiation dose. All (co)polymer films eroded completely within 28 days of implantation. Variation of the TMC content of gamma irradiated (co)polymer films did not affect the tissue response to the gamma irradiated (co)polymer films and their in vivo erosion behavior much. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.