bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Seizure-Related Impact Assessment Scale (SERIAS): a study protocol
Authors: Foster Emma , Conquest Alison , Ewart Chris , Nicolo John-Paul , Rayner Genevieve , Winton-Brown Toby , O'Brien Terence J , Kwan Patrick , Malpas Charles , French Jacqueline A 
Published: June 2024

IntroductionThis study aims to validate the Seizure-Related Impact Assessment Scale (SERIAS). This novel patient-reported outcome measure (PROM) compares the ‘trade-off’ between seizures and treatment-related adverse effects, and measures epilepsy disability qualitatively and quantitively. It fills an important gap in PROMs for epilepsy clinical trials and practice.Methods and analysisAdults with epileptologist-confirmed epilepsy from two Australian Epilepsy Centres are being recruited. People with functional seizures, or who are unable to self-complete English-language validated instruments are excluded. Participants providing informed consent are invited to complete questionnaires at baseline, 3 and 6 months later. SERIAS includes five questions that ask about the number of days per month that seizures or treatment-related adverse effects partially or fully impact work/home/school and family/social/non-work activities, as well as a visual analogue scale regarding epilepsy-related disability. SERIAS is completed alongside seven internationally validated instruments measuring treatment-related adverse effects, mood disorders and quality of life. Target recruitment is n=100, ensuring>50 people complete all questionnaires at all timepoints. Comprehensive psychometric analysis will be performed. Convergent validity will be investigated using bivariate correlations with relevant measures. Reliability will be investigated using Cronbach’s alpha, McDonald’s omega and test–retest correlation coefficients. SERIAS will be a novel PROM for epilepsy clinical trials and practice.Ethics and disseminationMultisite ethics approval was granted by the Alfred Health Ethics Committee (HREC 17/23). Results of this study will be disseminated through publication in peer-reviewed journals and presentations at scientific conferences.Trial registration numberACTRN12623000599673.
Weekly iron-folic acid supplementation and its impact on children and adolescents iron status, mental health and school performance: a systematic review and meta-analysis in sub-Saharan Africa
Authors: Kedir Shemsu , Hassen Abate Kalkidan , Mohammed Bekri , Ademe Beyene Wondafrash 
Published: June 2024

ObjectiveThis systematic review and meta-analysis aimed to comprehensively assess the impact of weekly iron-folic acid supplementation (WIFAS) on the nutrition, health and educational outcomes of children and adolescents in sub-Saharan Africa.DesignA systematic review and meta-analysis was used.Data sourcesFive databases, namely, MEDLINE, Scopus, Web of Science, Cochrane Library and Google Scholar, were systematically searched for relevant articles up to 23 August 2023.Eligibility criteriaIt was focused on randomised controlled trials involving children and adolescents in sub-Saharan Africa, exploring the effects of iron supplementation on various outcomes, such as serum ferritin and haemoglobin levels, anaemia, mental health and school performance.Data extraction and synthesisThe Joanna Briggs Institute Critical Appraisal tools were used for quality assessment, with two independent reviewers thoroughly evaluating each paper. Using the Cochrane risk of bias tool, we evaluated the certainty of evidence such as the risk of bias, inconsistency, indirectness, imprecision and publication bias.ResultsA systematic review of 10 articles revealed that WIFAS significantly increased serum ferritin levels in adolescent girls (Hedge’s g=0.53, 95% CI 0.28 to 0.78; heterogeneity I2=41.21%, p<0.001) and haemoglobin levels in school-aged children (Hedge’s g=0.37, 95% CI 0.01 to 0.73; heterogeneity I2=91.62%, p<0.001). The analysis further demonstrated a substantial reduction in the risk of anaemia by 20% (risk ratio=0.8, 95% CI 0.69 to 0.93; heterogeneity I2=28.12%, p<0.001).ConclusionWIFAS proved effective in enhancing serum ferritin and haemoglobin concentrations and lowering the risk of anaemia in school-aged children and adolescents compared with a placebo. Similarly, there are not enough studies to examine the effects of WIFAS on school performance. However, information regarding mental health problems, mortality and potential side effects remains insufficient.PROSPERO registration numberCRD42023397898.
Comparing the diagnostic efficacy of optical coherence tomography and frozen section for margin assessment in breast-conserving surgery: a meta-analysis
Authors: Fan Shishun , Zhang Huirui , Meng Zhenyu , Li Ang , Luo Yuqing , Liu Yueping 
Published: June 2024

AimsThis meta-analysis assessed the relative diagnostic accuracy of optical coherence tomography (OCT) versus frozen section (FS) in evaluating surgical margins during breast-conserving procedures.MethodsPubMed and Embase were searched for relevant studies published up to October 2023. The inclusion criteria encompassed studies evaluating the diagnostic accuracy of OCT or FS in patients undergoing breast-conserving surgery. Sensitivity and specificity were analysed using the DerSimonian and Laird method and subsequently transformed through the Freeman-Tukey double inverse sine method.ResultsThe meta-analysis encompassed 36 articles, comprising 16 studies on OCT and 20 on FS, involving 10 289 specimens from 8058 patients. The overall sensitivity of OCT was 0.93 (95% CI: 0.90 to 0.96), surpassing that of FS, which was 0.82 (95% CI: 0.71 to 0.92), indicating a significantly higher sensitivity for OCT (p=0.04). Conversely, the overall specificity of OCT was 0.89 (95% CI: 0.83 to 0.94), while FS exhibited a higher specificity at 0.97 (95% CI: 0.95 to 0.99), suggesting a superior specificity for FS (p＜0.01).ConclusionsOur meta-analysis reveals that OCT offers superior sensitivity but inferior specificity compared with FS in assessing surgical margins in breast-conserving surgery patients. Further larger well-designed prospective studies are needed, especially those employing a head-to-head comparison design.PROSPERO registration numberCRD42023483751.
Creating elastase aneurysms in rabbits: a video primer
Authors: Cortese Jonathan , Bayraktar Esref Alperen , Oliver Alexander A , Bilgin Cem , Ding Yong-Hong , Ueki Yasuhito , Lortscher Sarah , Brinjikji Waleed , Kadirvel Ramanathan , Kallmes David F 
Published: June 2024

The New Zealand rabbit elastase-induced arterial aneurysm of the right common carotid artery remains a widely used model for assessing the effectiveness and safety of new neuroendovascular devices.1 This model offers a simple and reliable platform for pre-clinicalin vivoinvestigations, crucial for comprehending the biological processes underlying aneurysm healing after endovascular treatment.2 Notably, the induced aneurysm exhibits morphological, hemodynamic, and histological characteristics similar to human intracranial aneurysms. The creation of the aneurysm is performed using open and endovascular techniques. Each step of the procedure requires a meticulous and controlled gesture to ensure reproducibility of the aneurysm and minimize animal misuse. In video 1 we present a step-by-step procedural guide for aneurysm creation and follow-up. We hope this resource will help in promoting this model and provide useful guidance for researchers in the field.Video 1Surgical procedure of creating elastase-induced aneurysms in rabbits.
Anatomical pattern of entheseal and synovial fibroblast activation in patients with psoriasis and its risk of developing psoriatic arthritis
Authors: Corte Giulia , Atzinger Armin , Temiz Selahattin Alp , Noversa de Sousa Rita , Mutlu Melek Yalcin , Schoenau Verena , Raimondo Maria Gabriella , Kleyer Arnd , Kuwert Torsten , Ramming Andreas , Simon David , Sticherling Michael , Schmidkonz Christian , Schett Georg , Fagni Filippo 
Published: June 2024

ObjectivesTo assess the presence and anatomical distribution of activated fibroblasts in the joints and entheses of patients with psoriasis with arthralgia and to test how fibroblast activation visualised by68gallium-labelled fibroblast activation protein inhibitor-04 (68Ga-FAPI-04)-positron emission tomography (PET)/CT correlates with clinical tenderness, musculoskeletal ultrasound findings and progression to psoriatic arthritis (PsA).MethodsWe conducted a prospective cohort study in patients with psoriasis and arthralgia who underwent clinical and ultrasound evaluation and whole-body PET/CT imaging with68Ga-FAPI-04.68Ga-FAPI-04 uptake at synovial and entheseal sites was assessed by maximal standardised uptake values (SUVmax) and PET/CT Joint Index (JI); logistic regression models were used to investigate its correlation with clinical and ultrasound findings. Survival analyses were performed on patients with at least 6 months of follow-up.Results36 patients with psoriasis were enrolled.68Ga-FAPI-04 uptake was found in 318 (7.9%) joints and 369 (7.3%) entheses in 29 (80.6%) participants, with a mean SUVmax (SD) of 3.2 (1.8) for joints and 2.9 (1.6) for entheses. Large joints and the lower limbs were predominantly affected. A significant positive relationship was found between68Ga-FAPI-04-PET/CT signal intensity and the 68 tender joint count (SUVmax: p<0.001; PET/CT-JI: p<0.001) and tender entheses count (SUVmax: p<0.001; PET/CT-JI: p=0.002). No correlations were found with ultrasound findings (SUVmax: p=0.969; PET/CT-JI: p=0.720). Patients with relevant synovio-entheseal68Ga-FAPI-04 uptake showed a statistically significant higher risk of developing PsA (p=0.02), independent of ultrasound findings.ConclusionsPatients with psoriasis presenting with arthralgia show localised signs of resident tissue activation in joints and entheses, which are associated with higher risk of developing PsA.
Synergistic interaction between pay-it-forward incentives and recreational drug use on hepatitis B virus and hepatitis C virus testing among men who have sex with men in China
Authors: Ai Wei , Xie Yewei , Lu Haidong , Ai Ting , Wu Dan , Zhang Ye , Marley Gifty , Ong Jason , Tucker Joseph D , Tang Weiming 
Published: June 2024

ObjectivesPay-it-forward incentives effectively promote hepatitis B virus (HBV) and hepatitis C virus (HCV) testing among men who have sex with men (MSM) by offering free testing and donation opportunities. This study aims to explore the interaction between pay-it-forward incentives and recreational drug use on HBV and HCV testing uptake among Chinese MSM.MethodsWe pooled data from two pay-it-forward studies that aimed to promote dual HBV and HCV testing among MSM in Jiangsu, China. We explored factors associated with hepatitis testing uptake in the two study groups and examined the interaction between pay-it-forward incentives and recreational drug use on hepatitis testing uptake.ResultsOverall, 511 MSM participated in these two studies, with 265 participants in the pay-it-forward incentives group and 246 participants in the standard-of-care group. Among these participants, 59.3% in the pay-it-forward incentive group and 24.8% in the standard-of-care group received dual HBV and HCV testing, respectively. In the pay-it-forward incentives group, participants who used recreational drugs in the past 12 months (adjusted OR (AOR)=1.83, 95% CI 1.09 to 3.06) were more likely to receive dual HBV and HCV testing, compared with those who never used recreational drugs, whereas in the standard-of-care group, those who used recreational drugs were less likely to receive dual HBC and HCV testing (AOR=0.38, 95% CI 0.18 to 0.78). MSM with higher community connectedness (AOR=1.10, 95% CI 1.00 to 1.21) were also more likely to receive hepatitis testing with pay-it-forward incentives. There was a synergistic interaction on both the multiplicative (ratio of ORs=4.83, 95% CI 1.98 to 11.7) and additive scales (the relative excess risk of interaction=2.97, 95% CI 0.56 to 5.38) of pay-it-forward incentives and recreational drug use behaviours on dual HBV and HCV testing uptake among MSM.ConclusionPay-it-forward incentives may be particularly useful in promoting hepatitis testing among MSM who use recreational drugs.
Constraining primordial black holes as dark matter using AMS-02 data
Authors: Su Bing-Yu , Pan Xu , Wang Guan-Sen , Zu Lei , Yang Yupeng , Feng Lei 
Published: June 2024

AbstractPrimordial black holes (PBHs) are the plausible candidates for the cosmological dark matter. Theoretically, PBHs with masses $$M_{\textrm{PBH}}$$

M
PBH

in the range of $$4\times 10^{14}\sim 10^{17}\,\textrm{g}$$

4
×

10
14

∼

10
17

g

can emit sub-GeV electrons and positrons through Hawking radiation. Some of these particles could undergo diffusive reacceleration during propagation in the Milky Way, potentially reaching energies up to the GeV level observed by AMS-02. In this work, we utilize AMS-02 data to constrain the PBH abundance $$f_{\textrm{PBH}}$$

f
PBH

by employing the reacceleration mechanism. Under the assumption of a monochromatic PBH mass distribution, our findings reveal that the limit is stricter than that derived from Voyager 1 data. This difference is particularly pronounced when $$M_{\textrm{PBH}}\lesssim 10^{15}\,\textrm{g}$$

M
PBH

≲

10
15

g

, exceeding an order of magnitude. The constraints are even more robust in a more realistic scenario involving a log-normal mass distribution of PBHs. Moreover, we explore the impact of varying propagation parameters and solar modulation potential within reasonable ranges, and find that such variations have minimal effects on the final results.
Plasma Extracellular MicroRNAs Associated With Cardiovascular Disease Risk Factors in Middle‐Aged and Older Adults
Authors: Karlin Hannah , Sooda Meera , Larson Martin , Rong Jian , Huan Tianxiao , Mens Michelle M. J. , van Rooij Frank J. A. , Ikram M. Arfan , Courchesne Paul , Freedman Jane E. , Joehanes Roby , Mueller Gregory P. , Kavousi Maryam , Ghanbari Mohsen , Levy Daniel 
Published: June 2024

Background
Extracellular microRNAs (miRNAs) are a class of noncoding RNAs that remain stable in the extracellular milieu, where they contribute to various physiological and pathological processes by facilitating intercellular signaling. Previous studies have reported associations between miRNAs and cardiovascular diseases (CVDs); however, the plasma miRNA signatures of CVD and its risk factors have not been fully elucidated at the population level.

Methods and Results
Plasma miRNA levels were measured in 4440 FHS (Framingham Heart Study) participants. Linear regression analyses were conducted to test the cross‐sectional associations of each miRNA with 8 CVD risk factors. Prospective analyses of the associations of miRNAs with new‐onset obesity, hypertension, type 2 diabetes, CVD, and all‐cause mortality were conducted using proportional hazards regression. Replication was carried out in 1999 RS (Rotterdam Study) participants. Pathway enrichment analyses were conducted and target genes were predicted for miRNAs associated with ≥5 risk factors in the FHS. In the FHS, 6 miRNAs (miR‐193b‐3p, miR‐122‐5p, miR‐365a‐3p, miR‐194‐5p, miR‐192‐5p, and miR‐193a‐5p) were associated with ≥5 risk factors. This miRNA signature was enriched for pathways associated with CVD and several genes annotated to these pathways were predicted targets of the identified miRNAs. Furthermore, miR‐193b‐3p, miR‐194‐5p, and miR‐193a‐5p were each associated with ≥2 risk factors in the RS. Prospective analysis revealed 8 miRNAs associated with all‐cause mortality in the FHS.

Conclusions
These findings highlight associations between miRNAs and CVD risk factors that may provide valuable insights into the underlying pathogenesis of CVD.
Antipsychotic medications and severe sepsis in schizophrenia: A nested case–control study
Authors: Chang Chun-Wei , Chen Wen-Yin , Chen Po-Yu , Pan Chun-Hung , Su Sheng-Shiang , Tsai Shang-Ying , Chen Chiao-Chicy , Kuo Chian-Jue 
Published: June 2024

Background: Sepsis constitutes a condition that involves life-threatening organ dysfunction induced by severe infection. This nested case–control study investigated risk factors for severe sepsis and whether antipsychotic use is associated with severe sepsis risk in patients with schizophrenia, a topic that has not been comprehensively explored in previous studies. Methods: We selected 39,432 patients with schizophrenia aged between 15 and 65 years from Taiwan’s Psychiatric Inpatient Medical Claims database for the period 2000–2012. The case group comprised patients with severe sepsis after their first psychiatric admission ( n = 1382). The case and control groups were randomly matched (1:4) by age, sex and first psychiatric admission (year) and finally comprised 1382 and 5528 individuals, respectively. We employed multivariable conditional logistic regression to identify (1) risk factors (physical illnesses and nonpsychiatric medications) and (2) antipsychotic–severe sepsis associations. Results: Higher numbers of psychiatric admissions and physical illnesses such as delirium, cerebrovascular disease and cancer were significantly associated with a higher risk of severe sepsis. Furthermore, severe sepsis was associated with the use of antithrombotic agents, systemic corticosteroids and agents targeting the renin–angiotensin system. Clozapine (adjusted risk ratio = 1.65) and quetiapine (adjusted risk ratio = 1.59) use were associated with an increased risk of severe sepsis. The use of more than one antipsychotic drug could further increase this risk. Conclusion: Several physical illnesses and nonpsychiatric medications increase the risk of severe sepsis in patients with schizophrenia. Specifically, clozapine or quetiapine use significantly increased the risk of severe sepsis in these patients.
Normalizing Abnormal Psychology: An Anti-Ableist Approach
Authors: Owenz Meghan B. , Aydemir-Döke Deniz , Spencer D. Brett 
Published: June 2024

Introduction A survey course of mental health diagnoses is a commonly taken undergraduate psychology course and presents a critical opportunity for addressing ableism in psychology. Statement of the Problem The presentation of mental health diagnoses is wrought with ableist beliefs, both in the historical and contemporary context. These ableist beliefs are a prime driver of stigma and its associated outcomes including worse mental health and avoidance of treatment professionals. Literature Review The present article presents the ableist context of the course typically titled, “Abnormal Psychology,” and offers an alternative: the building of an anti-ableist curriculum grounded in disability studies. We use the social model of disability and disability identity as guiding principles, while inquiry-based learning is the pedagogical driver. Teaching Implications We review six practical strategies, which include introducing the social model, renaming the class, starting with positive disability identity, complicating the continuum-categorical dichotomy, centering disability representation, and emphasizing consumer rights and direction. Conclusion By leaning on disability studies and Mad Pride, “Abnormal Psychology” can deconstruct its ableist roots and be the foundation for a destigmatized, positive approach towards the study of psychological disorders. We offer future directions, including potential ways to continually assess anti-ableist efforts.
Taking Seriously Campus Debates Surrounding Invited Speakers: Open-Mindedness and the Ethics of Inquiry in Higher Education
Authors: Taylor Rebecca M. 
Published: June 2024

Context: College campuses in the United States are currently engaged in public and ongoing negotiation of the value and limits of free speech in educational contexts. Responses to invited campus speakers from students, faculty, and campus leaders point to diverging perspectives on the roles and responsibilities of higher education institutions and their members as communities of inquiry. Considering these perspectives raises questions about the epistemic aims of colleges and universities. Purpose: The purpose of this article is to investigate perspectives on the ethics of inquiry and on the value and demands of open-mindedness in higher education. Specifically, I examined one case of an invited campus speaker who sparked considerable debate—Charles Murray’s invited talk at Middlebury College in 2017. Research Design: This study employs the methods of empirically engaged philosophy, a philosophical approach to inquiry that engages with empirical evidence in considering educational aims and implications for institutional structures and policies. I apply conceptual tools stemming from the philosophical theories of knowledge and justice to a thematic content analysis of public statements made by faculty, administrators, and students in the Middlebury case. Conclusions or Recommendations: Through analysis of this campus speaker case, I observed two alternative perspectives on the ethics of inquiry—rational individualism and just collectivism. These two perspectives shared a number of common commitments, including the importance of cultivation of the mind as a primary aim in higher education; the value of open-mindedness, debate, and protest in the pursuit of truth; and the importance of justice, equality, and inclusion. They diverged in their epistemic orientations (individual vs. collective responsibility), their views on the proper bounds of open debate within an institution oriented toward truth-seeking, and what virtuous open-mindedness requires of individuals and collectives. This study contributes to a contemporary understanding of the unique ethical responsibilities of colleges and universities as inquiring organizations, whose members may hold divergent epistemological orientations. By investigating the relationship between open-mindedness, inquiry, and justice in contemporary public discourse in higher education, this study addresses a need for deeper engagement with the philosophical foundations of higher education.
From a Spark, a Mighty Flame: How Germinal Networks Support Teachers of Color to Promote Change in Activist Organizations and Beyond
Authors: Baker-Doyle Kira J. , Mawhinney Lynnette 
Published: June 2024

Background: Recent research has demonstrated that social justice teacher activist networks provide vital support to teachers of Color, reducing feelings of isolation and providing high-quality professional learning opportunities. Yet, there is a need for broader scaled research that looks across multiple activist organizations to add to our understandings of these findings. Focus of Study: Our study examines the network participation characteristics of 26 activist teachers of Color across 14 activist organizations in the United States. Our research questions were: (1) How do activist teachers of Color foster social capital in networks to influence policies and actions in their organizations and beyond? (2) What relationship exists between the participation structures of networks and the involvement of teachers of Color in the activist organizations? Research Design: Our research design used a critical social network research approach informed by Black feminist thought (BFT) and research on teacher activism. Our data included interviews from the 26 teachers and documents from their activist organizations. Our analysis involved a macro-to-micro qualitative network analysis of data, which afforded a broad view of network characteristics and deep descriptions of the stories of a subset of teachers. Conclusions: We found that the teachers of Color who were involved in affinity-based groups and subgroups were often the germinators of policy and action shifts, usually related to racial and intersectional justice in their organization. We call this network phenomenon a germinal network. We explore other features of germinal networks, such as a tendency toward reflexivity and mentorship-seeking and support. This study has implications for future critical research on social networks and the design of radically inclusive and humanizing social infrastructures in education-related organizations.