bluuebunny/crossref_metadata_2025_split huggingface dataset:
Das Respiratorische Synzytialvirus (RSV)
Authors: Bösl Sabina , Fischbach Thomas , Agyeman Philipp , Redlberger-Fritz Monika , Kostenzer Johanna , Schultz Carmen , Tischer Christina , Trück Johannes , Zimmermann Luc , Siche-Pantel Franziska , Mader Silke 
Published: June 2024

ZUSAMMENFASSUNG
Hintergrund und Ziel Das Respiratorische Synzytialvirus (RSV) ist eine der häufigsten Ursachen für Atemwegsinfektionen bei Säuglingen und Kleinkindern und trägt das Risiko für schwere Krankheitsverläufe. In einem partizipativen Vorgehen hat die European Foundation for the Care of Newborn Infants (EFCNI) ein Positionspapier entwickelt, welches Handlungsempfehlungen für Entscheidungstragende aus Politik, Gesundheitsversorgung und Wissenschaft formuliert (Deutschland, Österreich, Schweiz).
Material und Methoden Im Rahmen des Projektes wurden insgesamt vier digitale Rundtischgespräche organisiert. Die aktuelle Situation wurde zusammen mit deutschsprachigen RSV-Expertinnen und Experten relevanter Fachrichtungen evaluiert. Das Positionspapier wurde mit allen Teilnehmenden in mehreren Runden diskutiert und abgestimmt.
Ergebnisse und Diskussion Im D-A-CH-Raum werden die Risiken von RSV nach wie vor unterschätzt und es existieren derzeit keine einheitlichen Behandlungsempfehlungen. Der Rundtisch fordert daher insbesondere eine zielgruppenübergreifende Bewusstseinsbildung, vermehrte Aufklärungsarbeit sowie die fortlaufende Aktualisierung von Leitlinien.
Cistus×incanus L. – eine potente Heilpflanze zur
Prävention auf vielen Ebenen
Authors: Gündling Peter W. 
Published: June 2024

ZusammenfassungZistrosengewächse (Cistaceae) sind in den letzten Jahren recht intensiv beforscht
worden. Dabei standen Extrakte der Graubehaarten Zistrose
(Cistus×incanus L.) aufgrund ihres hohen Gehaltes an
Polyphenolen mit an erster Stelle. Die meisten dieser Arbeiten beschäftigen sich
mit der Bestimmung dieser Polyphenole und ihrer Komponenten sowie deren
antioxidativen Wirkungen. Auch neue Wirkmechanismen, wie antiinflammatorische,
antiglykämische und lipidsenkende, konnten aufgezeigt werden. Und nicht zuletzt
ist es auch das starke antivirale Potenzial, das bestimmte Subspezies
auszeichnet und das eine wichtige Bedeutung in der Prophylaxe und Therapie von
Infektionen hat.
Das Phytotherapeutikum Cimicifuga racemosa
(Traubensilberkerze)
Authors: Klose Petra 
Published: June 2024

ZusammenfassungFrauen mit Brustkrebs leben oft mit erheblichen Nebenwirkungen einschließlich der
Einleitung einer frühen Menopause, die u. a. zu vasomotorischen Symptomen,
Stimmungsschwankungen und muskuloskelettalen Schmerzen führt. Präparate aus der
Traubensilberkerze (Cimicifuga racemosa) können hier eine Therapieoption
darstellen, da in zahlreichen Studien das geringe Nebenwirkungspotenzial
nachgewiesen werden konnte. Traubensilberkerze wirkt auch nicht als
Phytoöstrogen, was bei den meisten Brustkrebsarten kontraindiziert wäre. Es gibt
zudem Hinweise, dass die Einnahme von Traubensilberkerze die Wirkung von
Tamoxifen unterstützt. Studien zur Linderung von Hitzewallungen bei menopausalen
Frauen durch Traubensilberkerze sind zwar nicht einheitlich, die Europäische
Arzneimittelagentur EMA kommt jedoch zu dem Schluss, dass die
Nutzen-Risiko-Abwägung für die Einnahme von Traubensilberkerze spricht. Zur
Behandlung von Brustkrebspatientinnen gibt es wenige Studien, und nur eine
Studie, die über einen längeren Zeitraum dauerte, zeigte signifikante Linderung
im Vergleich zur Kontrolle. Doch auch für Brustkrebspatientinnen spricht die
Datenlage zur Sicherheit nicht gegen die Einnahme, sodass die EMA die Begleitung
durch den behandelnden Arzt empfiehlt.
Rupturierte pulmonale Echinococcus granulosus-Zyste – Eine seltene Ursache für eine schwere pneumogene Sepsis
Authors: Früh Jonas , Fieber Lukas , Held Matthias , Müller Andreas 
Published: June 2024

ZusammenfassungEchinokokkosen sind in Deutschland seltene parasitäre Erkrankungen, eine Infektion mit Echinococcus granulosus tritt v.a. bei Menschen mit Migrationshintergrund auf. Am häufigsten sind Leber und Lunge befallen. Pulmonale Zysten führen oft erst bei Ruptur zu Symptomen. Die Kombination aus bildgebenden Verfahren und Serologie erlaubt meist eine Diagnose, gelegentlich ergänzt durch molekulargenetische Methoden. Angesichts globaler Migrationsbewegungen sollte in den differenzialdiagnostischen Überlegungen auch die Epidemiologie häufiger Erkrankungen im Herkunftsland berücksichtigt werden.
Wir präsentieren den ungewöhnlichen Fall einer pneumogenen Sepsis bei einem jungen Mann aus Syrien, bei dem die Kombination aus Anamnese sowie radiologischer, serologischer und molekulargenetischer Untersuchungen schließlich zur Diagnose einer schweren pulmonalen Echinokokkose mit Ruptur führte.
5(S)-5-Carboxystrictosidine from the Root of Mappianthus iodoides Ameliorates H2O2-induced Apoptosis in H9c2 Cardiomyocytes via PI3K/AKT and ERK Pathways
Authors: Han Ying , Xi Junli , Zhang Puzhao , Gong Ming , Luo Tao , Shao Feng , Li Yongxin , Zhong Lingyun , Quan Hexiu 
Published: June 2024

Abstract5(S)-5-carboxystrictosidine (5-CS) is a compound found in the root of Mappianthus iodoides, a traditional Chinese medicine used for the treatment of coronary artery disease. The aim of the present study was to investigate the protective effect of 5-CS against oxidative stress-induced apoptosis in H9c2 cardiomyocytes and the underlying mechanisms. 5-CS pretreatment significantly protected against H2O2-induced cell death, LDH leakage, and malondialdehyde (MDA) production, which are indicators for oxidative stress injury. 5-CS also enhanced the activity of SOD and CAT. In addition, 5-CS pretreatment significantly inhibited H2O2-induced apoptosis, as determined by flow cytometer, suppressed the activity of caspase-3 and caspase-9, and attenuated the activation of cleaved caspase-3 and caspase-9. 5-CS also increased Akt and ERK activation altered by H2O2 using Western blot analysis. The PI3K-specific
inhibitor LY294002 abolished 5-CS-induced Akt activation. The ERK-specific inhibitor PD98059 abolished 5-CS-induced ERK activation. Both LY294002 and PD98059 attenuated the protective effect of 5-CS on H9c2 cardiomyocytes against H2O2-induced apoptosis and cell death. Taken together, these results demonstrate that 5-CS prevents H2O2-induced oxidative stress injury in H9c2 cells by enhancing the activity of the endogenous antioxidant enzymes, inhibiting apoptosis, and modulating PI3K/Akt and ERK signaling pathways.
Effects of a Pharmacist-Designed Clinical Decision Support System on Antimicrobial Stewardship
Authors: Amor-García Miguel Ángel , Chamorro-de-Vega Esther , Rodríguez-González Carmen Guadalupe , Iglesias-Peinado Irene , Moreno-Díaz Raquel 
Published: June 2024

Abstract
Background Clinical decision support systems (CDSSs) are computer applications, which can be applied to give guidance to practitioners in antimicrobial stewardship (AS) activities; however, further information is needed for their optimal use.
Objectives Our objective was to analyze the implementation of a CDSS program in a second-level hospital, describing alerts, recommendations, and the effects on consumption and clinical outcomes.
Methods In October 2020, a pharmacist-driven CDSS designed for AS was implemented in a second-level hospital. The program provides a list of alerts related to antimicrobial treatment and microbiology, which were automatized for revision by the AS professionals. To analyze the implementation of the CDSS, a pre–post-intervention, retrospective study was designed. AS-triggered alerts and recommendations (total number and rate of acceptance) were compiled. The effect of the CDSS was measured using antimicrobial consumption, duration of antimicrobial treatments, in-hospital mortality, and length of stay (LOS) for patients admitted for infectious causes.
Results The AS team revised a total of 7,543 alerts and 772 patients had at least one recommendation, with an acceptance rate of 79.3%. Antimicrobial consumption decreased from 691.1 to 656.8 defined daily doses (DDD)/1,000 beds-month (p = 0.04) and the duration of antimicrobial treatment from 3.6 to 3.3 days (p < 0.01). In-hospital mortality decreased from 6.6 to 6.2% (p = 0.46) and mean LOS from 7.2 to 6.2 days (p < 0.01).
Conclusion The implementation of a CDSS resulted in a significant reduction of antimicrobial DDD, duration of antimicrobial treatments, and hospital LOS. There was no significant difference in mortality.
Metal-Free Synthesis of 2-Benzylideneindolin-3-ones via a Nucleophilic/Rearrangement/Azide–Alkene Cascade Reaction
Authors: Tang Quan , Huang Sheng-Chao , Wang Hua , Long Tianyu , Kong Han-Han , Wang Long , Yang Qing-Qing , Huang Nianyu 
Published: June 2024

AbstractA metal-free synthesis of 2-benzylideneindolin-3-ones through a formal [4+1] annulation from o-azidobenzaldehydes and terminal alkynes has been developed. The method features operational simplicity, mild reaction conditions, and ready availability of starting materials. A broad range of 2-benzylideneindolin-3-ones were prepared in moderate to excellent yields. Mechanistic studies indicated that the reaction might proceed through a nucleophilic addition/rearrangement/azide–alkene cycloaddition pathway to produce 2-benzylideneindolin-3-ones.
Venous Thromboembolism Prophylaxis Should Be Recommended for Antepartum Admissions and Cesarean Delivery if Age and Body Mass Index Are Greater Than 35
Authors: Shields Laurence E. , Feldman Daniele , Klein Catherine , Foster Mindy , Lin Stephanie 
Published: June 2024

Objective Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality. Current expanded treatment recommendations result in the inclusion of a large percentage of the obstetric population, which has limited their adoption. The purpose of this study was to identify a population at high risk for VTE, with minimal impact on the number of patients that would qualify for expanded treatment.
Study Design We performed a retrospective analysis of a large obstetric population. International Classification of Diseases, 10th Revsion (ICD-10) codes for VTE were used to identify patients presenting for obstetric or postpartum (PP) care from January 2016 to March 2018. The review focused on high-risk factors (history of VTE or high-risk thrombophilia), antepartum hospital admissions that were >72 hours in the previous 30 days, use of sequential compression devices, body mass index (BMI; kg/m2), age, and mode of delivery. Pharmacologic treatment efficacy was set at 90, 75, or 50%.
Results During the 27-month review period, there were 120,235 deliveries and 93 had a VTE event in the index pregnancy or within 4 weeks PP (7.7/10,000 births). A history of VTE or high-risk thrombophilia was seen in 25.8% of cases. Antepartum admission was noted in 40.9%, and the combination of cesarean delivery (CD) with age and BMI ≥35 (Age + BMI + CD) was noted in 17.3% of PP cases. Targeting these latter two groups for VTE prophylaxis with a 75% efficacy suggests that 34% of the VTE events would likely have been prevented while increasing the total population treated by approximately 2%.
Conclusion Expanding pharmacologic prophylactical coverage to include an antepartum admission of >72 hours and those with Age + BMI + CD would result in about a one-third reduction in total VTE events with about 2% requiring treatment. These data support some of the suggested recommendations for expanded pharmacological deep venous thrombosis prophylaxis.
Key Points
Palladium-Catalyzed Amino-Sulfonylation of Aryl Iodide Derivatives via the Insertion of Sulfur Dioxide: One-Pot Synthesis of Aryl Primary Sulfonamides with Thiourea Dioxides
Authors: Li Yong , Cheng Kai , Ge Panyu , Zhou Ziyi , Tao Jiahao , Cai Wei , Wu Minqin , Shan Xinggang 
Published: June 2024

AbstractA palladium-catalyzed one-pot amino-sulfonylation of aryl iodide derivatives with thiourea dioxide, PdCl2dppf, and one-pot added hydroxylamine-O-sulfonic acid is presented. This amino-sulfonylation gave structure diversity to aryl primary sulfonamides and features good functional group compatibility, mild reaction conditions, excellent regioselectivity, and moderate to good yields. The robustness and potential of this method have also been successfully demonstrated by late-stage elaboration and gram-scale reaction. This approach achieves the divergent construction of the complex core structures that are prevalent in highly valuable natural products such as Sulpiride, Venetoclax, and Furosemide­.
Does New WHO 2022 Nomenclature of Pituitary Neuroendocrine Tumors Offer an Extra Edge to the Neurosurgeons for Its Management? A Narrative Review
Authors: Srivastava Alok , Singh Manish , Yadav Awadhesh , Srivastava Chhitij , Chandra Anil , Srivastava Akanksha D. 
Published: June 2024

AbstractThe new World Health Organization nomenclature of pituitary tumors was introduced in the year 2022 after much deliberation. This nomenclature clearly demarcates the anterior lobe (adenohypophyseal), posterior lobe (neurohypophyseal), and hypothalamic tumors. There is also focus on other tumors arising in the sellar region. The nomenclature has also advocated the routine use of immunohistochemistry in describing the pituitary transcription factors that plays a fundamental role in distinguishing the cell lineage of these tumors. However, the nomenclature is complex in understanding due to inclusion of pathological correlates like transcription factors, hormones, biomarkers, and various controversies that have emerged regarding the renaming of pituitary adenomas (PA) as PiTNETs (“Pituitary Neuroendocrine tumors”) because majority of the adenomas are benign and have rare metastatic behavior while classifying them as PiTNETs will create unnecessary misinterpretation of these as aggressive tumors that will lead to apprehension among the patients. The new classification gives deeper insight into the histological picture of the various pituitary tumors but other than contributing to the follow-up strategy and postsurgery management, this classification does not add anything new that could be advantageous for the neurosurgeons in clinical practice and decision making, especially in deciding the plan of action for surgery. Hence, there is need of a more comprehensive, integrated, neuroradiological-based classification with more emphasis on the invasiveness of these tumors that would assist the neurosurgeons in planning the treatment strategy and managing patients of pituitary tumors.
RP-HPLC-DAD Method Development and Validation for 1,3,4-Oxadiazole Derivative to Evaluate Its Forced Degradation Behavior and Stability
Authors: Deshpande Shridhar Narayan , BC Revana Siddappa , Khot Kartik Bhairu , Rajesh Gupta Dheeraj , Lobo Cynthia Lizzie 
Published: June 2024

AbstractIn the current study, a straightforward high-performance liquid chromatographic (HPLC) approach was developed and validated to identify a novel drug compound called 5-(4-bromophenyl)-N-(2-chloro-4-nitrophenyl)-1,3,4-oxadiazol-2-amine (A3). By putting the compound's solution under hydrolytic, oxidative, and photolytic stress, the method's capacity to detect stability was put to the test. A gradient mobile phase of acetonitrile, orthophosphoric acid, and methanol (90:051:05 v/v), at a flow rate of 1.00 mL/min, was used for the chromatographic separation on a C18 column (Promosil, 5μ, 4.60 250 mm), which was maintained at 40°C and a photodiode array detector was used for detection. At concentrations between 10 and 100.00 μg/mL, Beer's rule was observed. The recovery (99.25–100%, standard deviation [SD] 5%), intraday accuracy and precision (98.62–99.91%, relative standard deviation [RSD] 5%), interday accuracy and precision (96.25–99.91%, RSD 5%), and intermediate accuracy and precision (98.10–99.91%, RSD 5%) all indicated that the developed method was reliable, repeatable, reproducible, and robust. In cases of thermal and moisture deterioration, respectively, the compound's peak resolution and selectivity factors from the nearest resolving peak revealed specificity and selectivity. The selected synthesized compound barely broke down under oxidative and alkaline hydrolytic stress. However, the compound was resistant to photolysis in neutral and acidic environments. The results of this study demonstrate the sensitivity, specificity, and selectivity of the established approach for quality control, stability testing, and preformulation investigations.
Sports-Related Cervical Spine Injury: A Series of Two Cases with Literature Review
Authors: Ranjan Nitish , Maurya Ved Prakash , Bhaisora Kamlesh Singh , Srivastava Arun Kumar 
Published: June 2024

AbstractSports-related cervical injuries pose a significant concern in the realm of sports medicine, affecting athletes across various disciplines and levels of competition. Cervical injuries in sports primarily result from a combination of high-impact forces, sudden acceleration–deceleration movements, and improper techniques. Common cervical injuries include sprains, strains, fractures, and more severe conditions such as cervical spine dislocations. The mechanisms underlying sports-related cervical injuries involve complex interactions between biomechanical forces, player dynamics, and environmental factors. Understanding the biomechanics of these injuries is crucial for developing effective preventive strategies. This study highlights the mechanism of injury, primary intervention including transport of athletes, and medical and surgical management with the help of two such cases managed in a single institute in this year, 2023. By addressing the multifaceted aspects of these injuries, the sports community can strive toward creating a safer environment for athletes and minimizing the impact of cervical injuries on their overall well-being and athletic performance.
Impact of the ARRIVE Trial in Nulliparous Individuals with Morbid Obesity: Interrupted Time Series Analysis
Authors: Atwani Rula , Saade George , Huang Jim C. , Kawakita Tetsuya 
Published: June 2024

Objective We aimed to examine rates of induction of labor at 39 weeks and cesarean delivery before and after the ARRIVE (A Randomized Trial of Induction Versus Expectant Management) trial stratified by body mass index (BMI; kg/m2) category.
Study Design This was a repeated cross-sectional analysis of publicly available U.S. birth certificate data from 2015 to 2021. We limited analyses to nulliparous individuals with a singleton pregnancy, cephalic presentation, without chronic hypertension, diabetes (gestational or pregestational), and fetal anomaly who delivered between 39 and 42 weeks' gestation. The pre-ARRIVE period spanned from August 2016 to July 2018 and the post-ARRIVE period spanned from January 2019 to December 2020. The dissemination period of the ARRIVE trial was from August 2018 to December 2018. Our co-primary outcomes were induction at 39 weeks and cesarean delivery. Our secondary outcomes were overall induction of labor and preeclampsia. We conducted an interrupted time series analysis after stratifying by prepregnancy BMI (<40 or ≥40). Negative binomial regression was used to calculate adjusted incident rate ratios with 95% confidence intervals.
Results Of 2,122,267 individuals that were included, 2,051,050 had BMI <40 and 71,217 had BMI ≥40. In individuals with BMI <40, the post-ARRIVE period compared to the pre-ARRIVE period was associated with an increased rate of induction of labor at 39 weeks, a decreased rate of cesarean delivery, and an increased rate of overall induction of labor. In individuals with BMI ≥40, the post-ARRIVE period compared to the pre-ARRIVE period was associated with an increased rate of induction of labor at 39 weeks, an increased rate of overall induction of labor and a decreased rate of preeclampsia; however, the decrease in the rate of cesarean delivery was not significant.
Conclusion An increase in induction of labor at 39 weeks' gestation in individuals with BMI ≥40 was not associated with a decrease in the cesarean delivery rate.
Key Points
Physical Health-Related Quality of Life and Postsurgical Outcomes in Brain Tumor Resection Patients
Authors: Chintapalli Renuka 
Published: June 2024

Abstract
Background Patient-reported outcome measures (PROMs) have gained traction in assessing patients' health around surgery. Among these, the 29-item Patient-Reported Outcomes Measurement Information System (PROMIS-29) is a widely accepted tool for evaluating overall health, yet its applicability in cranial neurosurgery remains uncertain.
Objective This study aimed to evaluate the predictive value of preoperative PROMIS-29 scores for postoperative outcomes in patients undergoing brain tumor resection.
Materials and Methods We identified adult patients undergoing brain tumor resection at a single neurosurgical center between January 2018 and December 2021. We analyzed physical health (PH) summary scores to determine optimal thresholds for predicting length of stay (LOS), discharge disposition (DD), and 30-day readmission. Bivariate analyses were conducted to examine the distribution of PH scores based on patient characteristics. Multivariate logistic regression models were employed to assess the association between preoperative PH scores and short-term postoperative outcomes.
Results Among 157 patients (mean age 55.4 years, 58.0% female), 14.6% exhibited low PH summary scores. Additionally, 5.7% experienced prolonged LOS, 37.6% had nonroutine DDs, and 19.1% were readmitted within 30 days. Bivariate analyses indicated that patients with low PH summary scores, indicating poorer baseline PH, were more likely to have malignant tumors, nonelective admissions, and adverse outcomes. In multivariate analysis, low PH summary scores independently predicted increased odds of prolonged LOS (odds ratio [OR] = 6.09, p = 0.003), nonroutine DD (OR = 4.25, p = 0.020), and 30-day readmission (OR = 3.93, p = 0.020).
Conclusion The PROMIS-29 PH summary score serves as a valuable predictor of short-term postoperative outcomes in brain tumor patients. Integrating this score into clinical practice can enhance the ability to anticipate meaningful postoperative results.
Phenotypic/Genotypic Profile of Children with Neuronal Ceroid Lipofuscinosis in Southern Brazil
Authors: Santos Berkmis Viana , de Souza Josiane , Zeny Michelle Silva , Santos Mara Lúcia Schmitz Ferreira , do Valle Daniel Almeida 
Published: June 2024

Abstract
Introduction Neuronal ceroid lipofuscinoses (CLNs) are a group of lysosomal storage disorders of genetic origin, characterized by progressive neurodegeneration and intracellular accumulation of autofluorescent lipopigment. Thirteen genes related to CLNs are currently described, showing genetic and allelic heterogeneity, most of them with an autosomal recessive pattern. Due to the few descriptions of cases related to CLNs in Brazil, it is necessary to describe the phenotypic and genotypic characteristics of these patients. This study aims to evaluate the genotypic profile and correlate it with the phenotypic characteristics of patients with CLN in a children's hospital.
Methods This study was performed as a descriptive cross-sectional study with analysis of medical records, imaging, and laboratory tests of patients who had a confirmed molecular diagnosis of CLN.
Results The sample consisted of 11 patients from nine families with different subtypes of CLNs (CLN2, 5, 6, 7, and 8), with CLN2 being the most prevalent in the study. A total of 16 mutation variants were identified in genes associated with the five CLNs described in this study, with typical and atypical clinical phenotypes depending on the subtype and its variants.
Conclusion Novel mutations identified in the patients in this study showed phenotypes of rapid and severe progression in the CLN2 patient and similar characteristics in CLN6 and CLN7 patients, as previously described in the literature.