bluuebunny/crossref_metadata_2025_split huggingface dataset:
Record Low Antarctic Sea Ice in Austral Winter 2023: Mechanisms and Predictability
Authors: Espinosa Zachary , Blanchard-Wrigglesworth Edward , Bitz Cecilia 
Published: May 2024

Since 2016, Antarctic sea ice area (SIA) has set three record summertime
minimums occurring in 2017, 2022, and 2023. These recent extremes
culminated in a record low SIA anomaly in austral winter 2023, when SIA
was over 2 million km^2 below climatology, resulting from negative
sea ice concentration (SIC) anomalies centered in the Ross, eastern
Weddell, and East Antarctic Seas. We show that a fully-coupled Earth
System Model run with historic and anthropogenic forcing and nudged to
observed winds over 1950-2023 reproduces the observed austral winter
2023 SIC anomalies. In a sensitivity test that had the impact of 2023
ENSO conditions removed via regression, we show that the 2023 transition
from La Niña to El Niño had a negligible impact. Next, using an ensemble
initialized on January 1st 2023 nudged to past years’ winds, we
demonstrate that ~70% of the total Antarctic SIA
anomaly was predictable six months in advance and driven by warm
Southern Ocean sea surface temperatures that developed prior to 2023,
with the remaining ~30% attributable to 2023
atmospheric circulation. Finally, an ensemble forecast suggests that
Antarctic SIA is likely to remain significantly below climatology in
austral winter 2024 due to continuing warm Southern Ocean conditions.
Treatment of cholangiocarcinoma by pGCsiRNA-vascular endothelial growth factor in vivo
Authors: Lu Shenglin , Li Jun 
Published: May 2024

Abstract

Background
The early diagnosis and treatment of cholangiocarcinoma may benefit from specific tumor markers to be used in clinical practice.

Objectives
To investigate whether the pGCsiRNA-vascular endothelial growth factor (VEGF) can affect the onset and progression of cholangiocarcinoma and its possible mechanism using the targeted therapy of nude mouse model of cholangiocarcinoma with attenuated Salmonella carrying the plasmid pGCsiRNA-VEGF.

Methods
The nude mouse model of cholangiocarcinoma was established by tail vein injection of QBC939 cells and given attenuated Salmonella carrying the plasmid pGCsiRNA-VEGF. One month later, the tumor volume of nude mice was observed, and the tumor growth curve was plotted. The harvested tumors were weighed and detected for tissue structural changes and cell death status by hematoxylin–eosin staining. The protein and mRNA expressions of VEGF, matrix metalloproteinase 2 (MMP2), and MMP9 were detected by Western blotting and PCR, respectively.

Results
The tumor volume and weight of the pGCsiRNA-VEGF group were significantly smaller than those of the mock and the si-scramble groups (P < 0.05). The expressions of VEGF, MMP2, and MMP9 at the transcriptional and translational levels were inhibited by pGCsiRNA-VEGF. PGCsiRNA-VEGF promoted tissue apoptosis and destroyed the tissue structure.

Conclusions
In vivo silencing of VEGF can affect cell survival and inhibit cell migration, invasion, and development, probably by enhancing apoptosis and inhibiting the expressions of MMP2 and MMP9.
Structural Analysis of Some Pottery Fragments Belonging to Hamangia (Phase III) Culture
Authors: Brezoi Dragos-Viorel , Iordache Adrian , Gheboianu Anca Irina , Voinea Valentina 
Published: May 2024

Abstract
The paper presents a structural analysis of two pottery fragments belonging to the Hamangia phase III Ceamurlia culture, discovered in a settlement with several living levels on the northern shore of Lake Techirghiol, at the Minerva – Paloda Hill. From two ceramic fragments, fired in a reducing atmosphere, samples were taken to perform X-ray diffraction (XRD) and wavelength‐dispersive X-ray fluorescence spectra (WDXRF) analyzes to determine the crystalline structure and composition of the ceramic materials. Digital optical microscopy was used to observe the details of the fracture surfaces of these ceramic fragments. This work contributes to the knowledge of the techniques and materials used by the Hamangia civilization in the manufacture of ceramic vessels.
Solar-Driven Photobleaching of Lignocellulosic Biomass
Authors: Grigorescu Ramona Marina , Iancu Lorena , Ion Rodica-Mariana , David Madalina Elena , Slămnoiu-Teodorescu Sofia 
Published: May 2024

Abstract
Lignocellulose material is the main natural resource for the pulp and paper industry, and for its application the material should have a degree of whiteness as high as possible. For this reason, different bleaching treatments were applied during time. In this paper, the photobleaching induced by solar light of a lignocellulosic biomass using NaClO was studied. The colorimetric measurements, UV spectra absorption, and FTIR spectra changes are evaluated and discussed in this paper. The changes of L*a*b parameters can be considered a proof of the reactions generated by hypochlorite radicals during solar light exposure, leading to a biomass whitening.
Temporal and spatial accounts of sound perception. An overview of the main historical sources and theoretical problems
Authors: Di Stefano Nicola 
Published: May 2024

Summary
Music has been primarily conceived as a temporal art. However, over the last two centuries or so, researchers across different disciplines including musicology, psychology, and philosophy, have been intrigued by the spatial nature of music and sounds, using spatial concepts to define music. This paper aims to demonstrate that an understanding of music perception from a temporal perspective inherently implies a certain spatial dimension. To do this, first, I briefly examine some key arguments that lead to conceiving sound perception in temporal terms. At the same time, I highlight some of the limitations of a purely temporal account of sound perception which necessitate the incorporation of spatial considerations into the conceptualization of sound perception. Consequently, I move on to consider prominent spatial accounts of musical sounds that have been elaborated by psychologists, musicologists, and music composers. In conclusion, I discuss some of the challenges arising from the analogy between music and space, whether conceived in perceptual or cognitive terms.
The white and black colour attributes in the Natural Colour System
Authors: da Pos Osvaldo , Fiorentin Pietro , Cristoforetti Giulia , Freuli Francesca , Guidolin Sara , Nitri Pasqualina , Salamina Concetta 
Published: May 2024

Abstract
This phenomenological research investigates how it is possible to determine the extent to which a chromatic colour appears white and black in order to use it to build a new Colour Rendering Index. We tested two methods of subjective evaluation; in the first, the perceptual presence of white (and black) in a colour alone was assessed on a unipolar intensity scale, independently for the two attributes. In the second method, evaluations of whiteness (and blackness) were conducted for colours presented in a sequence ordered from the least to the greatest presence of the respective attribute. In both tests evaluations were made either by moving an arrow on a slider from left (minimum) to right (maximum) or by choosing a grey cylinder that matched the same degree of similarity to white (and black) as the test colour. In four experiments, 16 colours of 4 hues and 4 different shades were studied; in a fifth experiment, 48 colours, 12 for each quadrant of the colour wheel, were studied; finally, in another test, 10 greys were studied. In the first three experiments, the results were unexpected, as the evaluations of whiteness and blackness were complementary, adding up to 100%, while in the current NCS, 100% includes not only the evaluation of white and black but also that of chromaticness, therefore white and black are not complementary. In the fourth and fifth experiments, the sum of the evaluations of white and black was always less than 100%, in accordance with the present NCS. In the last experiment, the evaluations of white and black given independently to the 10 greys samples were complementary, confirming the bipolar nature of white-black continuum. Suggestions have been provided to resolve the discrepancy between the results of this research and the structure of the current NCS.
The role of nitro oxidative factors in metabolic dysfunctions: A link between severe obesity and weight-loss treatment – a narrative review
Authors: Ion Razvan Marius , Sibianu Melania , Neagoe Radu , Sala Daniela , Beresescu Felicia , Daniealopol Valentin , Daniealopol Ruxandra , Muresan Mircea 
Published: May 2024

Abstract

Introduction: Metabolic syndrome (MS) is linked to oxidative stress and intracellular redox imbalance, both triggered by chronic inflammatory conditions. The aim of our research was to figure out if bariatric surgery changes the production of free radicals in obese people. In addition, the relationship between metabolic syndrome(MS) and associated conditions is represented by oxidative stress (OS) and intracellular redox imbalance, both of which are induced by the chronic inflammatory conditions that define MS.

Methods: The literature search was conducted on PubMed, Cochrane Library, and ScienceDirect, using terms related to severe obesity, nitro-oxidative factors, pro-inflammatory status and reactive oxygen species. Six studies were included. We included papers published till 2022, with a concentration on more recent publications (January 2019 to December 2022).

Results: Studies that analyzed the status of the patient after bariatric surgery at 1, 2, 3, 6, 12 months were included in the review, regarding inflammation: CRP levels,IL-6, and regarding oxidative stress: MPO serum activity, blood plasma proteins: dityrosine, kynurenine, glycophore, amyloid and Amadori products, had been found strongly statistically significant decreased at each periodic analyze, the same thing applied to regulatory hormones such as leptin, and due to the fact that these patients have the possibility to keep their weight stable for a longer period, all these factors kept their levels low even 4 years after the intervention.

Conclusion: Bariatric surgery is an efficient and quick solution in increasing the quality of life.
Diagnostic value of stress myocardial perfusion imaging in combination with computed tomography angiography for coronary slow flow
Authors: Ge Xin , Zhou Ding , Zhou Yanmin , Sun Jiahe , Jing Rui 
Published: May 2024

Abstract

Introduction: To date, there are few reports on computed tomography angiography (CTA) in combination with stress myocardial perfusion imaging (SMPI) in the diagnosis of coronary slow flow (CSF).

Methods: A total of 62 patients with suspected CSF who were scheduled to undergo CTA, SMPI and coronary angiography (CAG) from June 2019 to June 2021 were selected. With the results of CAG as the gold standard, the value of CTA plus SMPI in the diagnosis of CSF was analyzed.

Results: Of the 62 patients, 52 (83.87%) were diagnosed with CSF by CAG. The results of the Kappa consistency test showed that SMPI alone, CTA alone and SMPI plus CTA had 0.565, 0.396 and 0.881 consistency, respectively, with CAG in the diagnosis of CSF. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of SMPI plus CTA in the diagnosis of CSF were 98.08% (51/52), 90.00% (9/10), 96.47% (60/62), 98.08% (51/52), and 90.00% (9/10), respectively, all higher than those of SMPI or CTA alone (P<0.05). The areas under the receiver operating characteristic curves of SMPI alone, CTA alone and SMPI plus CTA in the diagnosis of CSF were 0.754, 0.771 and 0.940, respectively.

Conclusion: CTA and SMPI have high diagnostic values for CSF, and the results of their combination have high consistency with those of CAG.
Correlations of expressions of Toll-like receptor 4 and Janus kinase 3 in peripheral blood mononuclear cells with T helper 17 cell/regulatory T cell imbalance in patients with ankylosing spondylitis
Authors: He Ruyan , Liu Guangpu , Gu Fang , Yang Junxia , Li Meirong 
Published: May 2024

Abstract

Background
We aimed to analyze the correlations of the expressions of Toll-like receptor 4 (TLR4) and Janus kinase 3 (JAK3) in peripheral blood mononuclear cells (PBMCs) with T helper 17 cell (Th17)/regulatory T cell (Treg) imbalance in patients with ankylosing spondylitis (AS).

Methods
A total of 101 AS patients were enrolled into an AS group. Based on the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score, they were subdivided into a stable AS (ASS) group (BASDAI score <4 points, n=42) and an active AS (ASA) group (BASDAI score ≥4 points, n=59). Meanwhile, 50 healthy volunteers who received health examination in the same time period were assigned into a healthy control (HC) group. RT-qPCR was performed to determine the mRNA expressions of TLR4 and JAK3 in PBMCs. Enzyme-linked immunosorbent assay was conducted to measure the levels of Th17/Treg-related cytokines [interleukin (IL)-10, IL-17, IL-23, and transforming growth factor-β (TGF-β)] in the serum.

Results
The mRNA expressions of TLR4 and JAK3 had positive correlations with IL-17 (r=0.592, 0.542) and IL-23 levels (r=0.529, 0.590) (P 0.05). The levels of TLR4 mRNA, JAK3 mRNA, IL-17, and IL-23 were all correlated with the occurrence of AS (P<0.05). The areas under the receiver operating characteristic curves of TLR4, JAK3, and their combination in PBMCs for predicting the occurrence of AS were 0.912, 0.835, and 0.919, respectively.

Conclusions
TLR4 combined with JAK3 can effectively predict the occurrence of AS.
The Trends of Potential User Research from 2014-2023 Based on Bibliometric and Bertopic
Authors: Kun Liu , Alli Hassan , Rahman Khairul Aidil Azlin Abd 
Published: May 2024

Objective: Despite the increasing importance of lead generation research in increasing product or market share, cost and resource constraints have become a challenge for SMEs.Therefore, this study aims to explore and reveal research themes and market trends hidden in articles on lead generation over the past 10 years.
.
Theoretical Framework: In this study, qualitative and quantitative methods are combined, and three methods of bibliometrics, network analysis and BERTopic topic modeling are used to analyze the literature.

Method: A total of 7446 articles were analysed using bibliometrics, network analysis and BERTopic thematic modelling as the basis of a mixed method approach.

Results and Discussion: The study found that the field is currently experiencing a downward trend after a phase of rapid growth. During this period, the United States and China were the countries with the highest number of articles accounting for 77% of the total; the Journal of Cleaner Journal of Cleaner Production was the most cited journal. In addition, the potential user studies cover 43 mainstream topics, focusing on 6 aspects . In the in-depth analysis of the theme evolution, it was found that the potential user study gradually evolved from the initial multidimensional application to focus on open service, and was more oriented towards the public service field.

Research Implications: This provides a strong theoretical basis and practical guidance for identifying potential customers and increasing conversion rates and revenues.

Originality/Value: To our knowledge, this is the first study to use a mixed-methods approach to lead generation, which will help researchers to tackle more complex challenges and changes in the future.
Sistem Diagnosa Penyakit Pada Tanaman Jeruk Nipis Menggunakan Metode K-Means Berbasis Website
Authors: Aggommy Muhammad Noer 
Published: May 2024

Tanaman jeruk nipis sangat mudah ditanaman dikarenakan perawatannya yang tidak rumit dan bibit tanaman yang mudah di temukan, Keadaan tanaman jeruk nipis yang baik bisa dideteksi dengan mengidentifikasi penyakit pada tanaman jeruk nipis. Salah satu metode untuk mendeteksi penyakit tanaman jeruk nipis bisa dilakukan dengan K-Means. Aplikasi pengelompokan penyakit tanaman jeruk nipis menggunakan metode K-Means berbasis Website ini dapat mempermudah mendeteksi penyakti tanaman jeruk nipis , Aplikasi ini berbasis Website sehingga pengguna dapat dengan mudah menjalankan aplikasi ini. Pembuatan aplikasi sistem berbasis Website pendeteksi penyakit tanaman jeruk nipis menggunakan data 24 gejala dan 11 penyakit tanaman jeruk nipis yang dapat digunakan pengguna untuk mendeteksi terdapatnya penyakit pada tanaman jeruk nipis berdasarkan gejala-gejala yang dimasukan oleh User. Data gejala penyakit tanaman jeruk nipis yang dimasukan kedalam sistem adalah suatu data gejala penyakit tanaman jeruk nipis, Gejala- gejala tanaman jeruk nipis tersebut harus dimasukan secara lengkap, karena kesimpulan hasil diagnosa menggunakan persentase yang ditampilkan dihitung secara otomatis oleh sistem dengan menggunakan K-Means. Lalu pada pengujian data ini menggunakan metode K-Means mendapatkan persentase akurasi 80,9% dan presentase eror 19,1%. Kata kunci: K-Means, Data Mining, Clustering, Diagnosis Tanaman Jeruk Nipis.
PENERAPAN ELEMEN ARSITEKTUR DALAM MENINGKATKAN KUALITAS HIDUP LANSIA PADA RUANG PUBLIK
Authors: Sariputra Jefferson , Jayanti Theresia Budi 
Published: May 2024

Over time, older people experience physical and cognitive changes, such as: hearing, vision and physical strength impairment, which affect their well-being. Suitable mobile equipment should be considered. Seniors need a quiet space, good sleep, and social interaction. Elderly is synonymous with age and age, if discussed in general terms, life expectancy in Indonesia is quite low compared to other countries. One of the problems that occurs is due to higher levels of air pollution and a lack of implementing a healthy lifestyle. With the hope of improving the quality of life of the elderly and also the life expectancy of the elderly, we will implement several architectural elements that prioritize safety and comfort for the elderly. The problems that occur focus on the welfare of the elderly in Indonesia. The method of this research uses an architectural approach, which uses methods to analyze and design an architectural design object effectively. The results of this research develop the application of architectural elements which can later be applied to the use of building designs for the elderly. Architectural elements will be implemented based on the basic needs of the elderly.
Keywords: architectural elements; elderly; life expectancy
Abstrak
Seiring waktu, orang lanjut usia mengalami perubahan fisik dan kognitif, seperti: gangguan pendengaran, penglihatan dan kekuatan fisik, yang mempengaruhi kesejahteraan mereka. Peralatan bergerak yang sesuai harus dipertimbangkan. Lansia membutuhkan ruang yang tenang, tidur yang nyenyak, dan interaksi sosial. Lansia identik dengan umur maupun usia, jika dibahas scara umum, angka Usia harapan hidup di Indonesia tergolong cukup rendah dibandingkan negara – negara lain. Salah satu masalah yang terjadi dikarenakan tingkat polusi udara yang lebih tinggi dan kurangnya penerapan pola hidup sehat. Dengan memiliki harapan untuk meningkatkan kualitas hidup lansia dan juga angka usia harapan hidup lansia, akan melakukan penerapan beberapa elemen arsitektur yang mementingkan keamanan serta kenyamanan bagi lansia. Masalah yang terjadi berfokus kepada kesejahteraan lansia di Indonesia. Metode dari penelitian ini menggunakan pendekatan arsitektur, yang dimana penggunaan metode untuk menganalisis dan merancang suatu objek rancangan arsitektur secara efektif. Hasil penelitian ini mengembangkan penerapan elemen arsitektur yang nantinya dapat diterapkan ke dalam penggunaan desain bangunan untuk lansia. Elemen arsitektur nantinya akan diterapkan berdasarkan kebutuhan dasar para lansia.
Propeller Ceiling Effect in Forward Flight
Authors: Cai Jielong , Gunasekaran Sidaard 
Published: May 2024

The study extends the investigation of the fixed-pitch small-scale propeller in the ceiling effect to forward flight conditions at different propeller incidence angles. Force-based experiments, phase-locked particle image velocimetry (PIV), and surface oil flow visualization were conducted on two APC propellers at the University of Dayton Low Speed Wind Tunnel. For propellers in edgewise flight, the power required at constant thrust decreases at small advance ratios for each [Formula: see text] and then increases with a further increase in the advance ratio. Tilting the propeller forward reduces the ceiling effect benefits in both thrust and power, particularly at higher advance ratios. Performance similarity in the propeller ceiling effect at different [Formula: see text] is observed, and a performance prediction method is proposed. Phase-locked PIV showed an increase in the propeller inflow angle in the ceiling effect at small advance ratios, resulting in higher thrust generation. This effect reduces with an increase in the advance ratio due to minimized interactions with the ceiling plate. Hence, the measured propeller in-ceiling-effect (ICE) propeller performance cannot represent the propeller ICE performance at a higher forward flight speed. Additionally, PIV and surface flow visualization indicated the presence of a stagnation point on the ceiling plate near the trailing side of the propeller disk at higher advance ratios, leading to a reduction in propeller thrust generation.
Corner Vortex Structures Within Recirculation Zones of Confined Bluff-Body Flows
Authors: Squeo Joseph N. , Sykes Joshua P. , Comer Adam L. , Gallagher Timothy P. , Rankin Brent A. 
Published: May 2024

The vortical structures of recirculation zones in turbulent nonreacting and premixed reacting flows around confined equilateral-triangle bluff bodies are investigated using large-eddy simulations. A three-dimensional flow structure is observed within the recirculation zones of reacting and nonreacting cases; the structure includes both the “spanwise” vortices that extend the length of the recirculation zone and “corner vortex structures” that are situated adjacent to the bluff-body trailing edge and spanwise walls. The corner vortex structures enhance the mixing and residence times of fluid inside the recirculation zone. Fluid is circulated between the spanwise vortices and corner vortex structures. Corner vortex structures always appear downstream (relative to the local flow) of the boundary-layer separation location on the spanwise walls within the recirculation zone, and they are absent when boundary-layer formation on the spanwise walls is prevented. Laminar boundary-layer theory predicts the boundary-layer separation locations within [Formula: see text] of the calculated values from the large-eddy simulations in all but one case. These results suggest that 1) boundary-layer separation on the spanwise walls is a necessary condition for the formation of corner vortex structures, and 2) boundary-layer separation on the spanwise walls is caused by an adverse pressure gradient in the recirculation zone.
PENGARUH KOMPOSISI MEDIA TANAM TERHADAP PERTUMBUHAN BIBIT JAMBU BIJI
Authors: Suhaimi Suhaimi , Nurjani Nurjani , Santoso Eddy 
Published: May 2024

Jambu biji (Psidium guajava L) jenis tanaman dari luar yang sudah banyak dikembangkan di Indonesia. Penggunaan media tanam untuk pembibitan cangkokan berbagai jenis media tanam yang digunakan petani. Penggunaan media tanam yang tidak tepat menyebabkan bibit tanaman sering mati. Tujuan penelitian ini adalah untuk mencari keberhasilan tumbuh terbaik dari berbagai perlakuan komposisi media tanam terhadap pertumbuhan bibit jambu kristal. Bahan yang digunakan dalam penelitian ini adalah bibit cangkokan jambu kristal, tanah aluvial, sekam bakar, cocopeat, pupuk kandang ayam, paranet 80%, polybag 13x25, dan kapur dolomit Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) satu faktor perlakuan yaitu faktor komposisi media tanam. Masing-maasing perlakuan diulang sebanyak 4 kali, setiap ulangan terdiri 4 sempel tanaman sehingga jumlah tanaman seluruhnya adalah 112 bibit tanaman. Variabel yang diamati dalam penelitian ini yaitu penambahan tinggi tanaman, jumlah tunas, penambahan jumlah daun dan penambahan diameter batang. Berdasarkan penelitian dapat disimpulkan bahwa semua komposisi media tanam sama-sama baiknya.