bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distinctive clinical features between lymphoblastic and immunoblastic non‐Hodgkin's malignant lymphomas (Kiel's classification) in a series of 141 patients
Authors: Hórni B. , Trojani Monique , Eghbali H. , Durand M. , Coindre J. M. , Richaud P. , Hórni‐Simon Geneviève , Lagarde C. 
Published: July 2010

AbstractOut of a series of 427 NHML based on the Kiel classification and without previous treatment, 186 were of high grade malignancy and among them were 83 lymphoblastic (LB) and 58 immunoblastic (IB) lymphomas which were included in this study. The LB and IB, which represent the majority of high grade NHML, were compared regarding their clinical features and courses. Eight main criteria were significantly different between these two groups: age of patient, immunological history, mediastinal and pleural involvement, primary or secondary involvement of the bone marrow, secondary leukaemia, secondary meningeal involvement, and involvement of the facial region. Some of these differences (mediastinum and meningeal involvement) are related to subtypes within LB. The differences between these two groups suggest that different treatment programs may be warranted.
T Cell‐dependent B‐Cell proliferation and activation induced by administration of the drug diphenylhydantoin to mice
Authors: Gleichmann Helga I. K. , Pals Steven T. , Radaszkiewicz Thaddäus 
Published: July 2010

AbstractWe have postulated that binding of the hydrophobic anticonvulsant drug diphenylhydantoin (DPH) to lymphoid cells might induce graft‐versus‐host (GVH)—like cell reactions by T lymphocytes and thus trigger autoimmunization and lymphoma development observed in patients treated with DPH. This hypothesis was studied in mice by means of the popliteal lymph node (PLN) assay. DPH, injected s.c. into the footpads of mice, induced a significant T cell‐dependent PLN enlargement. The B cell‐derived population comprised the majority of cells in the enlarged PLN. A T cell‐dependent activation of Ig‐secreting cells in the PLN was induced by DPH. Thymectomy of young adult mice significantly amplified the PLN reaction to DPH and facilitated the activation of Ig‐secreting cells. Since injection of the hydantoin rings only completely failed to induce PLN reactions, it is assumed that the observed PLN reactions are caused by the phenyl groups and/or the highly reactive intermediates of DPH. In conclusion, DPH can induce a T cell‐dependent proliferation and functional activation of B cells. Conceivably, if such a process persists, it might lead to the GVH‐like lymphomagenesis and autoimmunization observed in patients treated with this drug.
Correlation of aberrant proliferation with T‐cell growth factor in adult T‐Cell leukemia cells
Authors: Tsuda Hiroyuki , Takatsuki Kiyoshi 
Published: July 2010

AbstractPeripheral blood lymphocytes from seven patients with adult T‐cell leukemia (ATL) were found to lack PHA‐responsiveness. However, in most of the cases, minute but distinct proliferation could be induced and maintained by human spleen cell conditioned medium containing PHA or by a combination of PHA and conditioned medium of gibbon cell line, MLA‐144 (MLA‐144 CM). These results indicate that the lack of response to mitogens of ATL cells might be attributed not only to the failure of these cells to produce T‐cell growth factor (TCGF) upon activation, but also to their poor responsiveness to TCGF. Furthermore, a direct proliferative response to mitogen‐free MLA‐144 CM was shown in two out of seven patients; these two patients experienced rapidly progressive clinical courses. This observation raises the possibility that TCGF promotes the growth of ATL cells in vivo, and is related to the clinical course of the disease.
Heterogeneity of the in vitro growth patterns in adult T‐Cell leukemia cells
Authors: Tsuda Hiroyuki , Takatsuki Kiyoshi 
Published: July 2010

AbstractAdult T‐cell leukemia (ATL) presents heterogenous clinical features, especially in its clinical course. To clarify the differences in the cell characteristics of these heterogenous forms, we studied the in vitro growth of ATL cells. Nine ATL patients were divided into two groups; 5 acute (group A) and 4 chronic (group B). Although in vitro spontaneous growth was observed only in 3 out of 5 cases in group A, the growth patterns were heterogenous. When crude interleukin 2 (IL‐2) was added to the culture, cells from all the cases in Group A showed marked proliferative responses; these patterns were also heterogenous. On the other hand, cells in group B displayed no or poor response. The degree of Tac (IL‐2 receptor) expression was high in group A but low in group B. These observations suggest that clinical heterogeneity might reflect, at least in part, the cellular heterogeneity in IL‐2 responsiveness as seen in vitro.
Myeloproliferative disorder therapy: assessment and management of adverse events—a cardiologist's perspective
Authors: Kenny Dermot 
Published: July 2010

AbstractAlthough some cardiac effects, such as palpitations and tachycardia, occur commonly in healthy people, they have also been shown to be associated with agents used to treat the myeloproliferative disorders. Various strategies exist to prevent and manage cardiac effects and minimise their impact on treatment compliance and persistence. These include pre‐therapy cardiac assessment, pharmacological intervention and referral to a cardiologist. Ultimately, treating physicians must use their discretion when deciding which management strategy to use and which cardiac side effects require referral to a cardiologist, but the value of continuous dialogue between specialists should not be ignored. Copyright © 2009 John Wiley & Sons, Ltd.
Myeloproliferative disorder therapy: assessment and management of adverse events—a dermatologist's perspective
Authors: Soutou Boutros , Aractingi Sélim 
Published: July 2010

AbstractDevelopment of cutaneous manifestations in patients with myeloproliferative disorders can be either due to the course of the disease itself or induced by some of the treatments given. The cutaneous manifestations may reveal an unknown haemopathy and/or indicate a poor prognosis. Some of these alter quality of life. Hydroxyurea has been shown to induce a variety of cutaneous adverse reactions ranging from benign effects such as hyperpigmentation to more severe leg ulcers and squamous cell carcinomas. Herein, we discuss the importance of undertaking regular physical examinations in order to identify and treat cutaneous manifestations early in their course. Copyright © 2009 John Wiley & Sons, Ltd.
Myeloproliferative disorder therapy: assessment and management of adverse events—a psychiatrist's perspective
Authors: McDonald Graeme 
Published: July 2010

AbstractChronic diseases such as the myeloproliferative disorders may mask a worsening emotional state in patients, which can be exacerbated by the addition of common treatments such as interferon‐α. Management of mood disturbances is best considered from the first consultation, as the negative impact of impaired emotional well‐being on physiological outcomes is well established in literature. It is therefore important for physicians to be mindful of their patients' emotional well‐being from the point of diagnosis and throughout therapy, and aware of the tendency for physicians to focus on the primary illness. The advice of a psychiatrist may prove useful when discussing management strategies for patients with identifiable mood disturbances. Copyright © 2009 John Wiley & Sons, Ltd.
Bridging the gap: the role of pharmacists in managing the drug supply cycle within non‐governmental organizations
Authors: Villacorta‐Linaza Rocio 
Published: July 2010

AbstractAccess to essential medicines remains one of the biggest problems that developing countries are facing in health care systems. Non‐governmental organizations (NGOs) are implementing health programmes on the ground in areas affected by natural disasters or conflict. A vital component of these health programmes is the drug supply system. Based on a field research conducted in Pakistan 2007 and a field work experience in Afghanistan within an international NGO—Merlin—this paper analysed the four functions of the Drug Supply Cycle (Selection, Procurement, Distribution and Use) focusing attention on the importance in management support systems once the emergency phase is over. It shows the core role that the pharmacist plays within NGOs as a member of the health staff with the ability to improve the management of the Drug Supply Cycle. Copyright © 2009 John Wiley & Sons, Ltd.
The effect of a metal plate barrier with circular holes in the forced convection of electronic equipment
Authors: Fujii Masao 
Published: July 2010

AbstractTwo rectangular block‐like elements configured as an electronic module are positioned in a parallel‐walled channel and cooled by forced convection airflow. A metal plate with circular holes as a barrier protrudes above the plane of the modules, which is intended to function as a cover for protecting them from mechanical or electromagnetic damage, or as a thermal control device. The per‐module heat transfer coefficients were measured in the presence of the barrier with various heights, H, and distances, L, between the module and the barrier. In the presence of the barrier with circular holes, the heat transfer coefficient for the two modules was significantly reduced. The corresponding Nusselt numbers are determined as a function of the Reynolds number and the H/L ratio. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20279
Compressing infrared spectrum of exhaust plume by wavelets
Authors: Wang Yanming , Tan Heping , Shuai Yong , Zhang Haochun 
Published: July 2010

AbstractA study on multivariate calibration for the infrared spectrum of rocket exhaust plume was presented. As samples taken in the data set, the apparent infrared radiative properties of the high‐temperature plume flowfield consisted of variable concentrations gas components and were obtained by using a flux method combined with a narrow‐band model and Mie theory. The discrete wavelet transformation as a pre‐processing tool was carried out to decompose the infrared spectrum and compress the data set. The compressed data regression model was applied to simultaneous multi‐component concentrations for determination of the exhaust plume. The compression performance with several wavelet functions at different resolution scales was studied, and the prediction reliability of the compressed regression model was investigated. Numerical experiment results show that the wavelet transform performs an effective compression preprocessing technique in multivariate calibration and enhances the ability in characteristic extraction of the exhaust plume infrared spectrum. Using the compressed data regression model, the reconstructing results are almost identical when compared to the original spectrum, and the original size of the data set has been reduced to about 5% while the computational time needed decreases significantly. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20280
Observation of surface crystal sublimation during frosting
Authors: Liang Zhanpeng , Peng Xiaofeng , Li Zhimin , Wang Buxuan 
Published: July 2010

AbstractMorphological variation of surface ice crystals on a cooling surface during frosting was visually observed using a microscope. In the full growth stage of a frost layer, unusual sublimation started from the root of a prism‐like crystal together with the growth of other nearby plate crystals. Under different environmental conditions, the sublimation could proceed in two ways: snapped at the neck or melted in the crown. Local negative saturation induced by the coupled distributions of temperature and humidity is proposed for interpreting this phenomenon. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20281
Experimental study on the small‐scale diffusion flame of ethanol and the wall temperature field
Authors: Gan Yunhua , Cheng Jing , Yang Zeliang 
Published: July 2010

AbstractAn experimental investigation was carried out on the diffusion flames of liquid ethanol burning in air. Ceramic tubes with different inner diameters were used as burners. Three different flame structures at different flow rates were identified and different combustion regions were divided based on the experimental results. Some relevant factors which may affect the flame height and width were discussed. The outer surface wall temperature field of the tubes was measured in the combustion process. The results showed that both flame height and flame width all increased proportionally with an increasing flow rate in the steady flame region. Both flame height and flame width decreased with a decreasing tube inner diameter at the same flow rate. By decreasing the tube inner diameter, the quenching flow rate was decreased, the flow rate according to the produced periodic explosive flame decreased, and the flow rate range of the steady flames decreased. The outer wall temperature field presented an exponential distribution, and the wall temperature reached the greatest value at the outlet of the ceramic tube. © 2009 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/htj.20282
Testing alternative erosivity indices to predict event soil loss from bare plots in Southern Italy
Authors: Bagarello V. , Ferro V. , Giordano G. 
Published: July 2010

AbstractMethods for predicting unit plot soil loss for the ‘Sparacia’ Sicilian (Southern Italy) site were developed using 316 simultaneous measurements of runoff and soil loss from individual bare plots varying in length from 11 to 44 m. The event unit plot soil loss was directly proportional to an erosivity index equal to (QREI30)1·47, being QREI30 the runoff ratio (QR) times the single storm erosion index (EI30). The developed relationship represents a modified version of the USLE‐M, and therefore it was named USLE‐MM. By the USLE‐MM, a constant erodibility coefficient was deduced for plots of different lengths, suggesting that in this case the calculated erodibility factor is representative of an intrinsic soil property. Testing the USLE‐M and USLE‐MM schemes for other soils and developing simple procedures for estimating the plot runoff ratio has practical importance to develop a simple method to predict soil loss from bare plots at the erosive event temporal scale. Copyright © 2009 John Wiley & Sons, Ltd.
Molecular imaging of mesothelioma by detection of manganese‐superoxide dismutase activity using manganese‐enhanced magnetic resonance imaging
Authors: Hasegawa Sumitaka , Koshikawa‐Yano Michiko , Saito Shigeyoshi , Morokoshi Yukie , Furukawa Takako , Aoki Ichio , Saga Tsuneo 
Published: July 2010

AbstractMalignant mesothelioma (MM) is a fatal malignancy with a rapidly increasing incidence in industrialized countries because of the widespread use of asbestos in the past centuries. Early diagnosis of MM is critical for a better prognosis, but this is often difficult because of the lack of disease‐specific diagnostic imaging. Here, we report that manganese‐enhanced magnetic resonance imaging (MEMRI) represents a promising approach for a more selective mesothelioma imaging by monitoring a high‐level expression of manganese‐superoxide dismutase (Mn‐SOD), which is observed in many MM. We found that most human MM cells overexpressed Mn‐SOD protein compared with human mesothelial cells and that NCI‐H226 human MM cells highly expressed Mn‐SOD and augmented Mn accumulation when loaded with manganese chloride (MnCl2). The cells showed marked T1‐signal enhancement on in vitro MRI after incubation with MnCl2 because of the T1 shortening effect of Mn2+. H226 subcutaneous tumor was preferentially enhanced compared with a lung adenocarcinoma cell tumor and another human MM cell tumor in MnCl2‐enhanced T1‐weighted MR image (T1WI), correlating with their respective Mn‐SOD expression levels. Moreover, in a more clinically relevant setting, H226 xenografted pleural tumor was markedly enhanced and readily detected by MEMRI using manganese dipyridoxyl diphosphate (MnDPDP), a clinically used contrast agent, as well as MnCl2. Therefore, we propose that MEMRI can be a potentially powerful method for noninvasive detection of MM, with high spatial resolution and marked signal enhancement, by targeting Mn‐SOD.
A generic approach to semantic video indexing using adaptive fusion of multimodal classifiers
Authors: Kim Dae‐Jin , Frigui Hichem , Fadeev Aleksey 
Published: July 2010

AbstractWe present a novel method for fusing the results of multiple semantic video indexing algorithms that use different types of feature descriptors and different classification methods. This method, called Context‐Dependent Fusion (CDF), is motivated by the fact that the relative performance of different semantic indexing methods can vary significantly depending on the video type, context information, and the high‐level concept of the video segment to be labeled. The training part of CDF has two main components: context extraction and algorithm fusion. In context extraction, the low‐level multimodal descriptors extracted by the different classification algorithms are combined and used to partition the feature space into clusters of similar video shots, or contexts. The algorithm fusion component assigns aggregation weights to the individual classifiers within each context based on their relative performance in that context. Results on the TRECVID‐2002 data collections show that the proposed method can identify meaningful and coherent clusters and that the performance of the different labeling algorithms can vary significantly across different clusters. Our initial experiments have indicated that the context‐dependent fusion outperforms the individual algorithms and the global fusion of those algorithms. We also show that using standard multimodal descriptors and a simplek‐NN classifier, the CDF approach provides results that are comparable to the state‐of‐the‐art methods in semantic indexing. © 2008 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 18, 124–136, 2008
Long‐term learning in content‐based image retrieval
Authors: Li Jing , Allinson Nigel M. 
Published: July 2010

AbstractIn content‐based image retrieval, relevance feedback is an interactive process, which builds a bridge to connect users with the search engine. It leads to much improved retrieval performance by updating the query and the similarity measure according to a user's preference; and recently techniques have matured to some extent. However, most previous relevance feedback approaches exploit short‐term learning (intraquery learning) that is dealing with the current feedback session but ignoring historical data from other users, which potentially results in a great loss of useful information. Fortunately, by recording and collecting feedback knowledge from different users over a variety of query sessions, long‐term learning (interquery learning) can be implemented to further improve the performance of content‐based image retrieval in terms of effectiveness and efficiency. For this reason, long‐term learning has an increasingly important role in multimedia information searching. No comprehensive survey of long‐term learning has been conducted to date. To this end, the article addresses this omission and offers suggestions for future work. © 2008 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 18, 160–169, 2008
Stereo image displaying based on both physiological and psychological stereoscopy from single image
Authors: Hou Chunping , Yang Jiachen , Zhang Zhuoyun 
Published: July 2010

AbstractImage retrieval is a hot topic in the field of computer vision. Displaying query image and retrieved image as three‐dimensional images can facilitate the users to evaluate the quality of the retrieved results. To show a single image in three‐dimensional appearance, we propose to generate stereo image based on both physiological and psychological stereoscopy. We have found out how psychological stereoscopy can strengthen or weaken physiological stereoscopy. On the basis of this, we propose to introduce random binocular disparities into the single image. The net effect of this operation is the better stereo perception. When compared with other algorithms, the proposed algorithm is simple and the computational cost is relatively low. The effectiveness of our algorithm is demonstrated on different types of images. Since the 3D images are difficult to be captured, the algorithms we proposed aiming to generate stereo image from a single image are of great importance to the development of the field of the 3D vision. © 2008 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 18, 146–149, 2008
The Ages & Stages Questionnaire: Social–Emotional: A validation study of a mother‐report questionnaire on a clinical mother–infant sample
Authors: Salomonsson Björn , Sleed Michelle 
Published: July 2010

AbstractMother‐report questionnaires of infant socioemotional functioning are increasingly used to screen for clinical referral to infant mental health services. The validity of the Ages & Stages Questionnaire: Social Emotional (ASQ:SE; J. Squires, D. Bricker, K. Heo, & E. Twombly, 2002) was investigated in a sample of help‐seeking mothers with young infants. It was compared with independent observer‐rated dyadic interactions, and the quality of dyadic relationships was rated by expert clinicians. The ASQ:SE ratings also were compared with questionnaires on maternal psychological stress and distress. The ASQ:SE did not correlate significantly with either external ratings of dyadic interaction or clinically assessed relationship qualities, though the latter two were strongly associated with each other. In contrast, ASQ:SE scores were associated with questionnaires relating to maternal psychological distress. This was especially true for mothers classified as depressed. Furthermore, reports on the ASQ:SE were strongly predicted by maternal stress. The study points to some problems with the concurrent validity of the ASQ:SE in clinical samples. It also demonstrates a close link between mothers' psychological distress and their ratings of infant social and emotional functioning. Further research should investigate the extent to which the ASQ:SE specifically measures infant functioning or maternal distress, and how it functions in clinical versus nonclinical samples.
Recommendations of the ICID task force for least developed countries in Asia
Authors: Taniyama Shigetaka 
Published: July 2010

AbstractThe least developed countries (LDCs) in Asia, as well as those in sub‐Saharan Africa, have not succeeded in improving their standards of living; and the number of poor in the LDCs has not yet shrunk due to economic stagnation and inapt policies amidst the ever‐increasing population.In order to help ameliorate such problems, the International Commission on Irrigation and Drainage (ICID) has an important role, which it is expected to play, in assisting the LDCs with irrigation and drainage with respect to technologies, institutions, etc., by all of its capabilities, including encouraging non‐ICID‐member LDCs to affiliate with ICID, with the intention of increasing and stabilizing the production of agriculture, the foundation for the economic development of LDCs and the economic sector in which most of the labour force of LDCs currently engage.The ICID Task Force for LDCs in Asia recommends, as the priority issues for LDCs to cope with, the promotion of participatory management of irrigation and drainage, the development of small, affordable and sustainable infrastructure, setting up substantive legal systems and laying the foundation of financial support, technology transfer and dissemination on irrigation and drainage skills to the farmer organizations, and the conservation and appropriate allocation of water resources. Copyright © 2009 John Wiley & Sons, Ltd.