bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palladium‐Catalyzed Oxidative sp2 CH Bond Acylation with Aldehydes
Authors: Baslé Olivier , Bidange Johan , Shuai Qi , Li Chao‐Jun 
Published: April 2010

AbstractAn efficient method was developed for the direct acylation of arene sp2 CH bonds with aldehydes using palladium acetate as catalyst and peroxide as oxidant. The solvent‐free oxidative acylation reaction assisted by a pyridine directing group provides an easy access to aromatic, aliphatic, and optical active ketones.
Enantioselective Hydrogenation of α‐Dehydroamino Acid Esters Catalyzed by Rhodium Complexes with Chiral Bisaminophosphine Ligands
Authors: Sun Xianfeng , Li Wei , Zhou Le , Zhang Xumu 
Published: April 2010

AbstractA highly efficient strategy for the synthesis of a series of chiral bisaminophosphine ligands was well established with several remarkable features. The synthetic utility of these ligands was explored for rhodium‐catalyzed asymmetric hydrogenations of α‐dehydroamino acid esters. Up to 98% ee values were achieved for the enantioselective synthesis of aminocarboxylic acids and their derivatives, which are very important chiral building blocks for the synthesis of a variety of natural products and biologically active molecules.
Myoclonus dystonia plus syndrome due to a novel 7q21 microdeletion
Authors: Saugier‐Veber Pascale , Doummar Diane , Barthez Marie‐Anne , Czernecki Virginie , Drouot Nathalie , Apartis Emmanuelle , Bürglen Lydie , Frebourg Thierry , Roze Emmanuel 
Published: April 2010

AbstractMyoclonus dystonia (M‐D) is a rare genetic movement disorder characterized by a combination of myoclonic jerks and dystonia. It is usually due to mutations in the SGCE gene. We report on a patient with a typical M‐D syndrome, but also short stature, microcephaly, and mental retardation. Molecular analysis showed no mutations within the SGCE gene but a microdeletion encompassing the SGCE gene in chromosome region 7q21. Array‐CGH analysis showed that the deletion spanned approximately 1.88 Mb. We suggest that M‐D plus patients with mental retardation, microcephaly, dysmorphism, or short stature, all frequently associated disorders, should be screened for 7q21 microdeletion. By examining previously published cases of mental retardation associated with pure 7q21 deletions, we identified two distinct regions of respectively 455 and 496 kb that are critical for mental retardation and growth retardation. Among the genes located within these regions, LOC253012, also known as HEPACAM2, is a good candidate for both mental retardation and microcephaly. © 2010 Wiley‐Liss, Inc.
Highly processible maleimide and nitrile functionalized benzoxazines for advanced composites applications
Authors: Chaisuwan Thanyalak , Ishida Hatsuo 
Published: April 2010

AbstractMaleimide and 2‐aminobenzonitrile (MIan)‐based benzoxazine has been synthesized and characterized. MIan contains imide, oxazine, and nitrile functional groups that can react almost simultaneously, leading to complicated reaction mechanisms. For understanding the fundamental polymerization mechanism, the model benzoxazine compound is synthesized. The ortho‐nitrile group in the model compound undergoes cyclization reaction, producing the thermally stable six‐membered ring species resulting in the excellent thermal properties of the material. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Die Elektrochemische Reduction Einiger Stilbenabkömmlinge
Authors: Elbs K. , Kremann R. 
Published: April 2010

Abstract
die Ergebnisse der elektrochemischen Reduktion des Sonnengelbs stimmen mit der Auffassung überein, dass dieser Farbstoff im wesentlichen aus p‐Azoxystilbendisulfonsäure besteht.
Sonnengelb, p‐Azostilbendisulfonsäure und auch p‐Dinitrostilbendisulfonsäure liefern bei der elektrochemischen Reduktion in alkalischer Lösung als Endprodukt ρ‐Azotoluoldisulfonsäure; die Aethylenbindung wird gesprengt und die zur Hydrazogruppe reduzierte Azogruppe durch den Luftsauerstoff wieder zurückgebildet.
p‐Dinitrostilben liefert bei der elektro‐chemischen Reduktion in alkalischer Lösung p‐Azoxystilben, in saurer Lösung nach dem Boehringerschen Verfahren p‐Diaminostilben.
Unter den nämlichen Bedingungen liefert p‐Dinitrodibenzyldisulfonsäure p‐Azodibenzydisulfonsäure, bezw. p‐Diaminodibenzyldisulfonsäure.
Aus Sonnengelb entsteht bei der Reduktion nach dem Boehringerschen Verfahren nebeneinander p‐Diaminostilbendisulfonsäure und p‐Toluidinsulfonsäure; unter denselben Bedingungen erzeugt p‐Dinitrostilbendisulfonsäure im wesentlichen nur p‐Diaminostilbendisulfonsäure.
Die elektromotorische Kraft der Daniellschen Ketten
Authors: Cohen Ernst , Commelin J. W. 
Published: April 2010

Abstract
Die von Chaudier ausgeführten Bestimmungen der E. M. K. von Daniell‐Ketten mit verdünnter Zinksulfatlösung und bei 150°C. gesättigter Kupfersulfatlösung sind wiederholt worden
Dabei hat sich ergeben, dass die E. M. K. dieser Ketten, ceteris paribus, bei Zunahme der Konzentration der Zinksulfatlösungen abnimmt. Ein Maximalwert (nach Chaudier bei etwa 1/2 g ZnS04.7H20 auf 100 g Wasser) liegt also nicht vor.
Ein Widerspruch zwischen dem Tatsachenmaterial und der von Nernst gegebenen Gleichung für die E. M. K. (Daniellscher Ketten) besteht nicht; der Verlauf der gefundenen Werte lässt sich im Gegenteil mittels dieser Formel vorhersagen.
Anodisches Verhalten von Zinn, Antimon und Wismut
Authors: Elbs K. , Thümmel H. 
Published: April 2010

Abstract
Unter Versuchsbedingungen, die bezüglich Stromdichte, Temperatur und Konzentration in sehr weiten Grenzen schwanken, geht in den Elektrolyten Natriumchlorid, Natriumsulfat, Salz‐und Schwefelsäure das Zinn stets zum weitaus grössten Teil zweiwertig anodisch in Lösung
Von den obigen Elektrolyten eignen sich für Antimon als Lösungsanode nur Natriumchlorid und Salzsäure als Elektrolyte. Es entstehen ausschliesslich Verbindungen des dreiwertigen Antimons
Das Wismut verhält sich als Anode dem Antimon ähnlich; es bilden sich nur Verbindungen des dreiwertigen Wismuts
FOXL2 versus SOX9: A lifelong “battle of the sexes”
Authors: Veitia Reiner A. 
Published: April 2010

AbstractTestis determination in most mammals is regulated by a genetic hierarchy initiated by the SRY gene. Early ovarian development has long been thought of as a default pathway switched on passively by the absence of SRY. Recent studies challenge this view and show that the ovary constantly represses male‐specific genes, from embryonic stages to adulthood. Notably, the absence of the crucial ovarian transcription factor FOXL2 (alone or in combination with other factors) induces a derepression of male‐specific genes during development, postnatally and, even more interestingly, during adulthood. Strikingly, in the adult, targeted ablation of Foxl2 leads to a molecular transdifferentiation of the supporting cells of the ovary, which acquire cytological and transcriptomic characteristics of the supporting cells of the testes. These studies bring many answers to the field of gonadal determination, differentiation and maintenance, but also open many questions.
Analysis of ancient human genomes
Authors: Shapiro Beth , Hofreiter Michael 
Published: April 2010

AbstractHigh‐capacity sequencing technologies have dramatically reduced both the cost and time required to generate complete human genome sequences. Besides expanding our knowledge about existing diversity, the nature of these technologies makes it possible to extend knowledge in yet another dimension: time. Recently, the complete genome sequence of a 4,000‐year‐old human from the Saqqaq culture of Greenland was determined to 20‐fold coverage. These data make it possible to investigate the population affinities of this enigmatic culture and, by identifying several phenotypic traits of this individual, provide a limited glimpse into how these people may have looked. While undoubtedly a milestone in ancient DNA research, the cost to generate an ancient genome, even from such an exceptionally preserved specimen, remains out of reach for most. Nonetheless, recently developed DNA capture methods, already applied to Neanderthal and fossil human mitochondrial DNA, may soon make large‐scale genome‐wide analysis of ancient human diversity a reality, providing a fresh look at human population history.
Real‐time detection of the morphological change in cellulose by a nanomechanical sensor
Authors: Zhao Liming , Bulhassan Ahmed , Yang Guoliang , Ji Hai‐Feng , Xi Jun 
Published: April 2010

AbstractUp to now, experimental limitations have prevented researchers from achieving the molecular‐level understanding for the initial steps of the enzymatic hydrolysis of cellulose, where cellulase breaks down the crystal structure on the surface region of cellulose and exposes cellulose chains for the subsequent hydrolysis by cellulase. Because one of these non‐hydrolytic enzymatic steps could be the rate‐limiting step for the entire enzymatic hydrolysis of crystalline cellulose by cellulase, being able to analyze and understand these steps is instrumental in uncovering novel leads for improving the efficiency of cellulase. In this communication, we report an innovative application of the microcantilever technique for a real‐time assessment of the morphological change of cellulose induced by a treatment of sodium chloride. This sensitive nanomechanical approach to define changes in surface structure of cellulose has the potential to permit a real‐time assessment of the effect of the non‐hydrolytic activities of cellulase on cellulose and thereby to provide a comprehensive understanding of the initial steps of the enzymatic hydrolysis of cellulose. Biotechnol. Bioeng. 2010;107: 190–194. © 2010 Wiley Periodicals, Inc.
Antibody expression kinetics in glycoengineered Pichia pastoris
Authors: Potgieter Thomas I. , Kersey Sean D. , Mallem Muralidhar R. , Nylen Adam C. , d'Anjou Marc 
Published: April 2010

AbstractGrowth of the antibody market has fueled the development of alternative expression systems such as glycoengineered yeast. Although intact antibody expression levels in excess of 1 g L−1 have been demonstrated in glycoengineered yeast, this is still significantly below the titers reported for antibody fragments in fungal expression systems. This study presents a simplified approach to estimate antibody secretion kinetics and oxygen uptake rate requirements as a function of growth‐rate controlled by a limiting methanol feed rate in glycoengineered Pichia pastoris. The yield of biomass from methanol and the specific oxygen requirements predicted in this study compare well with values reported in the literature for wild‐type P. pastoris, indicating the intrinsic nature of these yields independent of glycoengineering or the heterologous protein expressed. Specific productivity was found to be a non‐linear function of specific growth rate. Based on comparison with relationships between specific growth rate and specific productivity reported in the literature this correlation seems empirical in nature and cannot be established a priori. These correlations were then used in a simple mass balance based model to predict the cultivation performance of carbon limited cultivations under oxygen transfer limited conditions to indicate the usefulness of this approach to predict large scale performance and aid in process development. Biotechnol. Bioeng. 2010;106: 918–927. © 2010 Wiley Periodicals, Inc.
Long-term outcome of Nissen fundoplication in non-erosive and erosive gastro-oesophageal reflux disease
Authors: Broeders J A , Draaisma W A , Bredenoord A J , Smout A J , Broeders I A , Gooszen H G 
Published: April 2010

AbstractBackgroundNon-erosive (NERD) and erosive (ERD) gastro-oesophageal reflux disease (GORD) show similar severity of symptoms and impact on quality of life (QoL). Prospective data on long-term outcomes of antireflux surgery in NERD are lacking.MethodsSubjective and objective 5-year outcomes of Nissen fundoplication were compared in 96 patients with NERD and 117 with ERD, operated on for proton-pump inhibitor (PPI)-refractory GORD.ResultsPreoperative and postoperative QoL, PPI use, acid exposure time, symptom–reflux correlation, lower oesophageal sphincter (LOS) pressure and reoperation rates were similar in the two groups. At 5 years, relief of reflux symptoms was similar (NERD 89 per cent versus ERD 96 per cent), PPI use showed a similar reduction (82 to 21 per cent versus 81 to 15 per cent respectively; both P &lt; 0·001) and QoL score improved equally (50·3 to 65·2 (P &lt; 0·001) versus 52·0 to 60·7 (P = 0·016)). Five patients with NERD developed erosions after surgery; oesophagitis healed in 87 per cent of patients with ERD. Reduction in total acid exposure time (NERD 12·7 to 2·0 per cent versus ERD 13·8 to 2·9 per cent; both P &lt; 0·001) and increase in LOS pressure (1·3 to 1·8 kPa versus 1·2 to 1·8 kPa; both P &lt; 0·001) were similar. The reintervention rate was comparable (NERD 15 per cent versus ERD 12·8 per cent).ConclusionPatients with PPI-refractory NERD and ERD benefit equally from Nissen fundoplication. The absence of mucosal lesions on endoscopy in patients with proven PPI-refractory reflux disease is not a reason to refrain from antireflux surgery.
Monitoring oxygen uptake in 3D tissue engineering scaffolds by phosphorescence quenching microscopy
Authors: Guaccio Angela , Netti Paolo A. 
Published: April 2010

AbstractMeasuring oxygen concentration in three‐dimensional cultures, without interfering with cellular activities, is a fundamental request of tissue engineering research. Among the other techniques, it has been demonstrated that phosphorescence quenching microscopy (PQM) represents a valid tool for the detection of oxygen concentration in 3D environments. Indeed, it is not invasive, with high spatial and temporal resolution, and, once calibrated, it is not affected by the presence of extracellular matrix components and other environmental factors. In this work, a description of the PQM experimental set up for oxygen measurements in solutions and 3D polymer‐based cellular constructs is provided. Moreover, the advantage and the limits in the use of this technique are critically discussed to provide a technical note for future applications. © 2010 American Institute of Chemical Engineers Biotechnol. Prog., 2010
Strategies for selecting Recombinant CHO cell lines for cGMP manufacturing: Realizing the potential in bioreactors
Authors: Porter Alison J. , Dickson Alan J. , Racher Andrew J. 
Published: April 2010

AbstractManufacture of recombinant proteins from mammalian cell lines requires the use of bioreactor systems at scales of up to 20,000 L. The cost and complexity of such systems can prohibit their extensive use during the process to construct and select the manufacturing cell line. It is therefore common practice to develop a model of the production process in a small scale vessel, such as a shake‐flask, where lower costs, ease of handling, and higher throughput are possible. This model can then be used to select a small number of cell lines for further evaluation in bioreactor culture. Here, we extend our previous work investigating cell line construction strategies to assess how well the behavior of cell lines in such a shake‐flask assessment predicts behavior in the associated bioreactor production process. A panel of 29 GS‐CHO cell lines, all producing the same antibody, were selected to include a mixture of high and low producers from a pool of 175 transfectants. Assessment of this panel in 10 L bioreactor culture revealed wide variation in parameters including growth, productivity, and metabolite utilization. In general, those cell lines which were high producing in the bioreactor cultures had also been higher producing in an earlier shake‐flask assessment. However, some changes in rank position of the evaluated cell lines were seen between the two systems. A potential explanation of these observations is discussed and approaches to improve the predictability of assessments used for cell line selection are considered. © 2010 American Institute of Chemical Engineers Biotechnol. Prog., 2010
Rapid and Direct Conversion of Graphite Crystals into High‐Yielding, Good‐Quality Graphene by Supercritical Fluid Exfoliation
Authors: Rangappa Dinesh , Sone Koji , Wang Mingsheng , Gautam Ujjal K. , Golberg Dmitri , Itoh Hiroshi , Ichihara Masaki , Honma Itaru 
Published: April 2010

AbstractGraphene has attracted a great deal of attention in recent years due to its unusual electronic, mechanical, and thermal properties. Exploiting graphene properties in a variety of applications requires a chemical approach for the large‐scale production of high‐quality, processable graphene sheets (GS), which has remained an unanswered challenge. Herein, we report a rapid one‐pot supercritical fluid (SCF) exfoliation process for the production of high‐quality, large‐scale, and processable graphene for technological applications. Direct high‐yield conversion of graphite crystals to GS is possible under SCF conditions because of the high diffusivity and solvating power of SCFs, such as ethanol, N‐methyl‐pyrrolidone (NMP), and DMF. For the first time, we report a one‐pot direct conversion of graphite crystals to a high yield of graphene sheets in which about 90–95 % of the exfoliated sheets are <8 layers with approximately 6–10 % monolayers and the remaining 5–10 % are ≥10 layers.
ChemInform Abstract: K3TaF8 from Laboratory X‐Ray Powder Data.
Authors: Smrcok Lubomir , Cerny Radovan , Boca Miroslav , Mackova Iveta , Kubikova Blanka 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Solution‐Phase Approach to Nanocrystalline Niobates: Selective Synthesis of Sr0.4H1.2Nb2O6 ·H2O Nanopolyhedrons and SrNb2O6 Nanorods Photocatalysts.
Authors: Liang Shijing , Wu Ling , Bi Jinhong , Wang Wanjun , Gao Jian , Li Zhaohui , Fu Xianzhi 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Crystal Structure, and Vibrational Spectroscopy of K2Ca4Si8O21 — An Unusual Single‐Layer Silicate Containing Q2 and Q3 Units.
Authors: Arroyabe E. , Kaindl R. , Toebbens D. M. , Kahlenberg V. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Syntheses, Characterization, and Computational Study of WSF4 and WSF4·CH3CN.
Authors: Nieboer Jared , Hillary William , Yu Xin , Mercier Helene P. A. , Gerken Michael 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Does Iodate Incorporate into Layered Uranyl Phosphates under Hydrothermal Conditions?
Authors: Ling Jie , Wu Shijun , Chen Fanrong , Simonetti Antonio , Shafer John T. , Albrecht‐Schmitt Thomas E. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel Substituted Phenanthrenes and Polycyclic Heteroarenes by Pd‐Catalyzed, Direct, Intramolecular Arylation/Heteroarylation.
Authors: Yadav Ashok K. , Ila Hiriyakkanavar , Junjappa Hiriyakkanavar 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient One‐Pot Method for the Synthesis of N‐Methoxy‐N‐methyl Amides from Carboxylic Acids.
Authors: Kim Joong‐Gon , Jang Doo Ok 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organozinc Generation via the Titanium‐Catalyzed Activation of Alkyl Halides.
Authors: Fleury Lauren M. , Ashfeld Brandon L. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselective Iron‐Catalyzed Decarboxylative Allylic Etherification.
Authors: Trivedi Rushi , Tunge Jon A. 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Access to Extended Yagupolskii—Umemoto‐Type Reagents: Triflic Acid Catalyzed Intramolecular Cyclization of ortho‐Ethynylaryltrifluoromethylsulfanes.
Authors: Matsnev Andrej , Noritake Shun , Nomura Yoshinori , Tokunaga Etsuko , Nakamura Shuichi , Shibata Norio 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ruthenium‐Catalyzed Intramolecular Amination Reactions of Aryl‐ and Vinylazides.
Authors: Shou Wang Ge , Li Juan , Guo Tongxun , Lin Zhenyang , Jia Guochen 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gold‐Catalyzed Cyclization of Alkynylaziridines as an Efficient Approach Toward Functionalized N‐Phth Pyrroles.
Authors: Du Xiangwei , Xie Xin , Liu Yuanhong 
Published: April 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.