bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Phylogenetic Placement of the Recently Described Armored Scale Insect Abgrallaspis aguacatae and Several Congeners (Hemiptera: Diaspididae)
Authors: Rugman-Jones Paul F , Andersen Jeremy C , Morse Joseph G , Normark Benjamin B , Stouthamer Richard 
Published: January 2010

Abstract
‘Hass’ avocado, Persea americana Miller, fruit being imported into California from Mexico are infested with high levels of a previously unknown species of armored scale insect (Hemiptera: Diaspididae). This species has recently been described and given the name Abgrallaspis aguacatae Evans, Watson & Miller. However, the validity of morphological characters used to diagnose genera within the tribe Aspidiotini (Diaspididae) is the subject of continued debate. Here, we seek to circumnavigate the inherent problems associated with interpretation of somewhat plastic phenotypic characters. We use two different nuclear gene regions (28S and Elongation Factor 1α) and three different analysis methods (maximum parsimony, maximum likelihood, and Bayesian analyses) to infer phylogeny from DNA sequence data for 35 aspidiotine species. Our analyses suggest that the new species is misplaced in the genus Abgrallaspis Balachowsky and that this genus and several closely allied genera are paraphyletic or polyphyletic. The findings of our analyses are discussed specifically in relation to the current placement of A. aguacatae and more broadly in relation to the long-recognized problem of defining generic boundaries between Abgrallaspis, Diaspidiotus Berlese, and Hemiberlesia Cockerell.
Ground Ant Diversity (Hymenoptera: Formicidae) in the Iberá Nature Reserve, the Largest Wetland of Argentina
Authors: Calcaterra Luis A , Cuezzo Fabiana , Cabrera Sonia M , Briano Juan A 
Published: January 2010

AbstractThe Iberá Nature Reserve in northeastern Argentina protects one of the largest freshwater wetlands and reservoirs of species in South America. However, key invertebrate groups such as the ants (Hymenoptera: Formicidae) remain almost unknown. The main objective of this work was to study the ground ant diversity in four main habitats of Iberá: grasslands, savannas, forests, and floating islands. Pitfall traps were used to characterize ground foraging ant assemblages, compare ant diversity among environments, and establish habitat associations. We also used bait traps, manual collections, and Winkler and Berlese extractors on the ground, vegetation, and litter strata to increase the species inventory. In total, 94 species in 30 genera were captured, representing the highest number of species reported from a survey of a protected area of Argentina. The richest genus was Pheidole Westwood with 23 species including three species reported for the first time in Argentina. The most common species was Solenopsis invicta Buren. Overall, the savanna was the richest and most diverse habitat with the highest number of exclusive species and functional groups. The grassland showed the highest number of rare species, but only half of the expected species were captured. The forest showed the lowest ant richness, diversity, and equitability, but one half of the species were exclusive to forest habitat. Generalized myrmicines were predominant and dominant in all habitats. Our findings indicate that habitat specialization could be an important factor determining the organization of ant assemblages in Iberá. The protection of each of these unique and threatened natural habitats of Argentina is needed to ensure the long-term preservation of their exclusive ant species.
Metabolism of Imidacloprid in Workers of Reticulitermes flavipes (Isoptera: Rhinotermitidae)
Authors: Tomalski Michael , Leimkuehler William , Schal Coby , Vargo Edward L 
Published: January 2010

Abstract
The chloro-nicotinyl insecticide imidacloprid is used extensively as a soil treatment against subterranean termites. We conducted the first study of the metabolic fate of imidacloprid in termites, by exposing workers of the eastern subterranean termite, Reticulitermes flavipes (Kollar) (Isoptera: Rhinotermitidae) to radiolabeled imidacloprid through topical application and ingestion. Several days after topical application, we detected up to 11 radiolabeled compounds. The parent compound, IMI, and the following six metabolites were identified by liquid chromatography/mass spectrometry: olefin-imidacloprid (major metabolite), 4/5-OH imidacloprid, 4,5-di-OH imidacloprid, des-nitro olefin imidacloprid, des-nitro imidacloprid, and a glucuronide conjugate of des-nitro imidacloprid (des-nitro IMI-glu). Over time, detoxification of imidacloprid proceeded from less polar to more polar compounds, with des-nitro IMI-glu seeming to be the ultimate, major end product in surviving termites. Degradation of imidacloprid was limited to internal tissues of the termite. Workers fed wood treated with imidacloprid or provided with a treated substrate (sand) had metabolitic profiles similar to topically treated termites. Termites fed imidacloprid or exposed to it in soil excreted detectable amounts of all of the identified metabolites. Finally, we determined that imidacloprid metabolites were less toxic to termites than imidacloprid itself. Only the olefin-imidacloprid and 5-OH imidacloprid caused morbidity in termites exposed to sand treated with these compounds, but at concentrations ≈10–20-fold higher than the parent imidacloprid. Our results shed light on the metabolic pathway used by termites to detoxify imidacloprid and show how metabolism plays a key role in determining the availability of the active ingredient and its various metabolites for transfer among workers within the colony.
Early Skin Toxicity as a Predictive Factor for Tumor Control in Hepatocellular Carcinoma Patients Treated with Sorafenib
Authors: Vincenzi Bruno , Santini Daniele , Russo Antonio , Addeo Raffaele , Giuliani Francesco , Montella Liliana , Rizzo Sergio , Venditti Olga , Frezza Anna Maria , Caraglia Michele , Colucci Giuseppe , Del Prete Salvatore , Tonini Giuseppe 
Published: January 2010

AbstractIntroduction.Sorafenib is an oral multikinase inhibitor that targets Raf kinase and receptor tyrosine kinases and has led to a longer median overall survival (OS) time and time to progression (TTP) in patients with advanced hepatocellular carcinoma (HCC). This study was conducted to assess the link between the antitumor efficacy of sorafenib and its early cutaneous side effects in advanced HCC patients.Materials and Methods.All patients received 800 mg daily of sorafenib until progression or unacceptable toxicities. We retrospectively analyzed the incidence of rash and hand–foot skin reactions (HFSR) during the first month of treatment, comparing tumor control (partial response plus stable disease) and TTP.Results.Sixty-five HCC patients treated with sorafenib were included in this analysis: 47 (73.3%) received sorafenib after failure of some local treatment, whereas 18 (27.7%) received it as first-line treatment. Twenty-nine patients developed at least grade 1 skin toxicity (rash, 13; HFSR, 16). In patients who developed skin toxicity, the tumor control rate was 48.3%, versus 19.4% in patients without cutaneous side effects. The median TTP was 8.1 months in the group of patients with skin toxicity versus 4.0 months in those without skin toxicity. This difference was also statistically significant on multivariate analysis. A borderline statistically significant difference was also observed in terms of OS in patients with early skin toxicity.Conclusions.Skin toxicity should be closely monitored in HCC patients treated with sorafenib in relation to its potential role as a surrogate marker of efficacy.
Responding to the Challenges of "Against Intellectual Monopoly"
Authors: Vertinsky Liza S. 
Published: January 2010

Abstract
Most would agree that a sound patent system is one in which the social benefits of the system exceed the social costs. Many would also agree that the current patent system imposes significant social costs, and that the current proposed patent reform legislation is largely motivated by a desire to address those costs. In their book, Against Intellectual Monopoly (2008), Boldrin and Levine base their policy recommendation to abolish the patent system on the claim that the social costs of having any patent system, even an “improved” or “reformed” one, will inevitably exceed its benefits. I argue that while Against Intellectual Monopoly falls short of establishing a case for abolishing the patent system, it succeeds in making a case for rethinking the law and economics paradigm of patents that has formed the foundation for much of patent law scholarship and policy. The arguments that Boldrin and Levine offer provide compelling reasons for re-examining the core assumptions underlying the dominant models of how patents impact innovation, paying greater attention to institutional alternatives and to historical lessons about the strength of competitive markets and the costs and benefits of regulatory intervention that dampens competition. I suggest we can meet the challenges highlighted by Boldrin and Levine by providing a more central role for New Institutional Economics (NIE) in the study of patent law, refocusing our analysis on the structure of activities and transactions that drive alternative processes of innovation and the roles that institutions (including but not limited to patent, contract and competition laws, and the informal rules governing collaboration and research activities) and organizations (both public and private) play in determining transactional structures and innovation outcomes.
Watt, Again? Boldrin and Levine Still Exaggerate the Adverse Effect of Patents on the Progress of Steam Power
Authors: Selgin George , Turner John L. 
Published: January 2010

Abstract
In an earlier comment on Boldrin and Levine’s 2003 lecture on patents and their effect on technology, we observed that their account of James Watt’s influence on the progress of steam technology contained factual errors which tended to exaggerate the negative consequences of Watt’s patent. We concluded that it was far from obvious that a corrected account would support Boldrin and Levine’s bold conjectures. While Boldrin and Levine’s 2008 “Against Intellectual Monopoly” begins with a new version of Watt’s story that claims to take our earlier criticisms into account, here we assess that version and conclude that it shares many of the shortcomings of the original.
A Recommendation on How to Intelligently Approach Emerging Problems in Intellectual Property Systems
Authors: North Douglass C. 
Published: January 2010

Abstract
We currently have no framework that allows us to really understand how a political system works, and how property rights and patent systems evolved, and so we do not have a body of theory that allows us to make predictive statements that would in fact lead to improving the function of property rights and patent systems. The body of neoclassical economic theory is very elegant and very useful, but it cannot describe how a system is evolving. If we want to understand how patent systems work, we may not simply rely on understanding the economics of patent systems, there must be developed a structure of incentives that will continue to encourage people to innovate and transform solutions to solve new and different problems that evolve over time. What we would ideally like in a world that is dynamic, where change is going on both in the political system and in the economic system, is to have an adaptively efficient structure.
A Rhetorical Response to Boldrin & Levine: Against Intellectual (Property) Extremism
Authors: McManis Charles 
Published: January 2010

Abstract
The two sides of the contemporary debate over intellectual property agree that the law needs to “strike a balance” between providing sufficient incentive for creation and the freedom to make use of existing ideas. Michele Boldrin and David Levine, on the other hand, boldly declare in their recent work “Against Intellectual Monopoly” that they have arrived at conclusions that “are at variance with both sides.” In this commentary, I examine 1) their assertion that intellectual property should be viewed as an “intellectual monopoly”; 2) their claim to have mustered evidence and authorities showing that innovators and creators can be well protected in the absence of intellectual property law; and 3) their rhetorical practices throughout the book. I conclude that 1) their assertion that intellectual property constitutes an “intellectual monopoly” is itself a bad analogy and an example of the logical fallacy of hasty generalization; 2) the evidence and authorities they muster in support of their claim that innovators and creators can be well protected in the absence of intellectual property law are unpersuasive, as they actually tend to support the opposite conclusion; and 3) their book as a whole is an example of bad rhetorical argumentation.
Introduction: The Kauffman Foundation Conference on Intellectual Property and Innovation
Authors: De Geest Gerrit 
Published: January 2010

Abstract
Introduction to the special issue on the Kauffman Foundation Conference on Intellectual Property and Innovation, held at St. Louis (USA) on April 2-3, 2009. This conference was organized by the Center on Law, Innovation and Economic Growth of the Washington University School of Law, and sponsored by the Ewing Marion Kauffman Foundation and the Skandalaris Center for Entrepreneurial Studies.
Randomized trial of a computerized coronary heart disease risk assessment tool in HIV-infected patients receiving combination antiretroviral therapy
Authors:   Swiss HIV Cohort Study, Bucher Heiner C , Rickenbach Martin , Young Jim , Glass Tracy R , Vallet Yannick , Bernasconi Enos , Cavassini Matthias , Fux Christoph , Schiffer Véronique , Vernazza Pietro , Weber Rainer , Battegay Manuel 
Published: January 2010

Background Exposure to combination antiretroviral therapy (cART) can lead to important metabolic changes and increased risk of coronary heart disease (CHD). Computerized clinical decision support systems have been advocated to improve the management of patients at risk for CHD but it is unclear whether such systems reduce patients’ risk for CHD. Methods We conducted a cluster trial within the Swiss HIV Cohort Study (SHCS) of HIV-infected patients, aged 18 years or older, not pregnant and receiving cART for >3 months. We randomized 165 physicians to either guidelines for CHD risk factor management alone or guidelines plus CHD risk profiles. Risk profiles included the Framingham risk score, CHD drug prescriptions and CHD events based on biannual assessments, and were continuously updated by the SHCS data centre and integrated into patient charts by study nurses. Outcome measures were total cholesterol, systolic and diastolic blood pressure and Framingham risk score. Results A total of 3,266 patients (80% of those eligible) had a final assessment of the primary outcome at least 12 months after the start of the trial. Mean (95% confidence interval) patient differences where physicians received CHD risk profiles and guidelines, rather than guidelines alone, were total cholesterol -0.02 mmol/l (-0.09–0.06), systolic blood pressure -0.4 mmHg (-1.6– 0.8), diastolic blood pressure -0.4 mmHg (-1.5–0.7) and Framingham 10-year risk score -0.2% (-0.5–0.1). Conclusions Systemic computerized routine provision of CHD risk profiles in addition to guidelines does not significantly improve risk factors for CHD in patients on cART.
The Strawberry Leaf Roller, Ancylis comptana fragariae (Walsh and Riley) (Lepidoptera: Tortricidae), as a Source of Overwintered Macrocentrus ancylivorus Rohwer (Hymenoptera: Braconidae) in Ontario
Authors: Putman Wm. L. 
Published: January 2010

AbstractMacrocentrus ancylivorus Rohwer overwintered in larvàe of the strawberry leaf roller, Ancylis comptana fragariae (Walsh & Riley), at the rate of from 544 to 7,623 per acre of strawberry field. Not more than 300 per acre of peach orchard, could be expected to overwinter in larvae of the Oriental fruit moth, Grapholitha molesta (Busck). About half of the larvae of M. ancylivorus in leaf rollers did not survive the winter.
The Olfactory Response of Ips confusus (LeConte) (Coleoptera: Scolytidae) to the Secondary Attraction in the Laboratory
Authors: Wood D. L. , Bushing R. W. 
Published: January 2010

AbstractA highly sensitive bioassay of the olfactory response of I. confusus is described. The response of beetles to air streams carrying attractants is a chemoklinotaxis but positive orientation occurs only in moving air. There is no evidence of ameno-taxis in odorless air streams or orientation to attractants in still air. Male behavior is characterized by an “area” orientation near the attractive material, an indirect approach to the source as shown by their entering adjacent air channels, and stopping frequently in the traverse during which they make klinotactic movements. The females exhibit a “point” or “straight-line” response, crawling directly to the source, rarely deviating into adjacent channels and only occasionally interrupting their approach.Bark-wood samples of ponderosa pine become attractive 4-6 hours after male beetles are introduced into preformed entrance tunnels, the peak attraction occurring between 18 and 144 hours. Frass is not attractive until 9-12 hours after introduction of males. The ratio of females to males responding positively during the peak attraction period was approximately 8:5. The level of attractiveness to females falls as the season progresses, the highest response being recorded in late May and June. Sexual maturity as judged by the appearance of motile sperm was not correlated with host feeding or the initiation of attraction. Frass of males boring in Douglas fir was unattractive to females.Attraction is initiated by male feeding in the phloem-cambial tissue of a host and is delayed until the first food has passed through the gut. The attractant appears to be associated with male excrement and may be produced, at least in part, in the hindgut.
Life Histories and Immature Stages of Four Ichneumonid Parasites of the European Pine Shoot Moth Rhyacionia buoliana (Schiff.) in Ontario
Authors: Arthur A. P. 
Published: January 2010

AbstractFour indigenous parasites of R. buoliana are discussed: Exeristes comstockii (Cress.), Scambus hispae (Harr.), Scambus tecumseh Vier. and Itoplectis conquisitor (Say). The first three are external larval parasites and the fourth an internal pupal parasite. Observations are given on the hosts, life histories, and habits under laboratory conditions. The immature stages are described.
The North American Species in Group I of Ips De Geer (Coleoptera: Scolytidae)
Authors: Hopping G. R. 
Published: January 2010

AbstractIps concinnus (Mannerheim) and Ips mexicanus (Hopkins) comprise Group I of the genus Ips DeGeer (Coleoptera: Scolytidae). Members of this group have 3 spines on each lateral margin of the declivity and strongly arcuate sutures on the anterior face of the antennal club. I. radiatae Hopkins is placed as a synonym of I. mexicanus (Hopkins). I. concinnus breeds in Picea sitchensis in the coastal region from Alaska to southern Oregon. I. mexicanus breeds in various species of pines from Alaska to Guatemala and eastward in the United States and Canada to the Rocky Mountains. A key to the species and descriptions are provided.
Studies of the Byron Bog in Southwestern Ontario XVII. Seasonal Distribution of Hemiptera (Corixidae, Notonectidae, Belostomatidae, Nepidae) in Redmond's Pond
Authors: Judd W. W. 
Published: January 2010

AbstractFrom May 8 to September 29, 1961 4 species of Corixidae, 5 o f Notonectidae, 1 of Belostomatidae and 1 of Nepidae were collected and the seasonal distribution of each species was noted.
Causes of Variations in Effectiveness of Bracon cephi (Gahan) (Hymenoptera: Braconidae) as a Parasite of the Wheat Stem Sawfly
Authors: Holmes N. D. , Nelson W. A. , Peterson L. K. , Farstad C. W. 
Published: January 2010

AbstractAdults of B. cephi emerged at the same time as the adults of their host, the wheat stem sawfly, and started to oviposit about mid-July. The second generation started to emerge between August 5 and 15. This generation, which was complete in some years, was apparently only partial in years in which adults of the first generation continued to oviposit late in the season. In most cases the larvae of Bracon that were present at harvest time were from eggs laid after August 1.Most of the overwintering B. cephi were located in the lower internodes of the sawfly-infested wheat stems. Although B. cephi attacked some sawfly larvae in their stubs most sawflies escaped parasitism once they had cut their host stems.High host densities per stem in hollow-stemmed wheats were detrimental to Bracon during the early part of the season as the unparasitized sawfly larvae in stems containing B. cephi destroyed the parasite larvae.The sawfly-susceptible wheats were more suitable than the resistant for parasitism. Generally, differences in parasitism between wheats and between barleys were caused by differences in length of survival of the sawfly larvae in the different host plants; longer survival led to higher parasitism.The fluctuations in amounts of parasitism mainly depended on the synchronization of development between B. cephi and the sawfly. Parasitism increased when the sawfly larvae cut their host stems sufficiently late to allow establishment by the second generation of B. cephi and decreased when the sawfly cut too early for parasitism by the second generation. The date of ripening of the host plant governs the date of cutting by the sawfly; hence, the amount of parasitism is influenced by the levels of soil moisture and temperature during the growing season, by differences in rate of development of various plant hosts, and by the date of seeding. Low levels of parasitism resulted from early ripening of the sawfly host plants in two consecutive years, whereas a moderately high level occurred even though the weather of the current year was conducive to early ripening, provided that the wheat in the preceding year had ripened late. It appears that moderate to high levels of parasitism required that the crop ripen late in at least one year out of two.
Studies on Oviposition and Fecundity of Ctenicera destructor (Brown) (Coleoptera: Elateridae)
Authors: Doane J. F. 
Published: January 2010

AbstractOviposition and fecundity of Cteniecra destructor (Brown) were studied in the laboratory and field. In a series of tests, total oviposition by individual field-collected females ranged from 495 to 1464 and averaged from 264.0 to 940.0 eggs per female. Temperatures from 50 to 86° F. had no effect on total fecundity but lower temperatures extended the oviposition period. Soil moisture from 8 to 20% in sifted clay loam soil (particle sine less than 0.177 mm.) had no effect on total oviposition. At 4% soil moisture females died rapidly and laid very few eggs. Food increased the total oviposition, the length of the oviposition period, and the longevity of females. Most eggs were laid during the first month after the onset of oviposition.Oviposition was shown to be cyclic in nature. Females usually laid eggs in large batches, followed by periods when practically no eggs were laid. This resulted in a series of irregular oviposition peaks which gradually declined in magnitude as the oviposition period progressed.