bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide profiling of chromosomal alterations in renal cell carcinoma using high‐density single nucleotide polymorphism arrays
Authors: Chen Meng , Ye Yuanqing , Yang Hushan , Tamboli Pheroze , Matin Surena , Tannir Nizar M. , Wood Christopher G. , Gu Jian , Wu Xifeng 
Published: June 2009

AbstractThe identification of genetic aberrations may help understand the mechanisms of tumorigenesis and has important implications in diagnosis, prognosis and treatment. We applied Illumina's 317K high‐density single nucleotide polymorphism (SNP) arrays to profile chromosomal aberrations in clear cell renal cell carcinoma (ccRCC) from 80 patients and analyzed the association of LOH/amplification events with clinicopathological characteristics and telomere length. The most common loss of heterozygosity (LOH) were 3p (69 cases) including 38 whole 3p arm losses, 30 large fragment LOH (spanning 3p21‐36), and 1 interstitial LOH (spanning 3p12‐14, 3p21‐22, 3p24.1‐24.2 and 3p24.3), followed by chromosome losses at 8p12‐pter, 6q23.3‐27, 14q24.1‐qter, 9q32‐qter, 10q22.3‐qter, 9p13.3‐pter, 4q28.3‐qter and 13q12.1‐21.1. We also found several smallest overlapping regions of LOH that contained tumor suppressor genes. One smallest LOH in 8p12 had a size of 0.29 Mb and only contained one gene (NRG1). The most frequent chromosome gains were at 5q (32 cases), including 10 whole 5q amplification, 21 large amplifications encompassing 5q32‐ter and 1 focal amplification in 5q35.3 (0.42 Mb). The other common chromosome gains were 1q25.1‐qter, 7q21.13‐qter, 8q24.12‐qter and whole 7p arm. Significant associations of LOH at 9p, 9q, 14q and 18q were observed with higher nuclear grade. Significant associations with tumor stage were observed for LOH at 14q, 18p and 21q. Finally, we found that tumors with LOH at 2q, 6p, 6q, 9p, 9q and 17p had significantly shorter telomere length than those without LOH. This is the first study to use Illumina's SNP–CGH array that provides a close estimate of the size and frequency of chromosome LOH and amplifications of ccRCC. The identified regions and genes may become diagnostic and prognostic biomarkers as well as potential targets of therapy. © 2009 UICC
Cognitive adaptation training for outpatients with schizophrenia
Authors: Draper Meredith L. , Stutes Donna S. , Maples Natalie J. , Velligan Dawn I. 
Published: June 2009

AbstractSchizophrenia is a complex neurodevelopmental disorder characterized by cognitive deficits. These deficits in cognitive functioning have been shown to relate to a variety of functional and treatment outcomes. Cognitive adaptation training (CAT) is a home‐based, manual‐driven treatment that utilizes environmental supports and compensatory strategies to bypass cognitive deficits and improve target behaviors and functional outcomes in individuals with schizophrenia. Unlike traditional case management, CAT provides environmental supports and compensatory strategies tailored to meet the behavioral style and neurocognitive deficits of each individual patient. The case of Ms. L. is presented to illustrate CAT treatment. © 2009 Wiley Periodicals, Inc. J Clin Psychol: In Session 65:1–12, 2009.
Mercury removal: a physicochemical study of metal interaction with natural materials
Authors: Carro Leticia , Herrero Roberto , Barriada José L. , Sastre de Vicente Manuel E. 
Published: June 2009

AbstractBACKGROUND: Mercury is considered one of the most harmful heavy metals to the environment and human health, so recently remediation processes have been developed to eliminate this metal from wastewaters. Metal retention by natural polymers is a good alternative technique to remove heavy metals from solution.RESULTS: A screening of 25 potential mercury sorbents was carried out at three different pH values in order to find appropriate biomass to remove this metal from polluted waters. High sorption capacities were found for many of the materials studied. Four of these materials were selected for further detailed study. Kinetic studies showed short times to reach equilibrium. For S. muticum, sorption isotherms were obtained at several temperatures and a sorption enthalpy value was obtained. Desorption experiments were performed to determine the possibility for recycling of this brown alga.CONCLUSIONS: Different materials have been found to be potentially good adsorbents of mercury. A detailed study showed that S. muticum is an excellent material with a mercury uptake about 200 mg g−1. This brown alga has a fast kinetic process (80% of metal is removed from solution in 30 min), and very high metal uptake over a wide pH range, up to 92% elimination for pH values above 3–4. Copyright © 2009 Society of Chemical Industry
Cichoric acid production from hairy root cultures of Echinacea purpurea grown in a modified airlift bioreactor
Authors: Abbasi Bilal Haider , Liu Rui , Saxena Praveen K. , Liu Chun‐Zhao 
Published: June 2009

AbstractBACKGROUND: Hairy root cultures of Echinacea offer great potential for the production of valuable cichoric acid, but scale‐up of the culture in the bioreactor represents a big challenge. Therefore, there is great interest in developing a suitable bioreactor for hairy root culture of Echinacea and novel bioprocessing strategies for intensifying cichoric acid production.RESULTS: Homogenous distribution of inoculum roots and high cichoric acid production were observed in a bioreactor modified by installing a mesh draught tube with an average pore size 700 µm, slightly larger than the hairy root, about 500 µm. Improved root growth and cichoric acid production were improved by increasing the aeration rate from 0.002 m3 h−1 to 0.012 m3 h−1. The hairy root cultures in the modified bioreactor exposed once to 6 min of ultrasound treatment at day 20 gave the highest biomass accumulation of 12.8 ± 0.3 g L−1, which resulted in the maximum cichoric acid production of 178.2 ± 4.9 mg L−1 at day 30.CONCLUSION: The present work demonstrated the effectiveness of hairy root culture in a modified airlift bioreactor. The biomass distribution remained homogenous in the modified airlift bioreactor, and the cichoric acid production was improved owing to the even root growth at optimal air flow rate. An interesting finding of this investigation was that ultrasound stimulated root growth and cichoric acid production considerably in the modified airlift bioreactor. Copyright © 2009 Society of Chemical Industry
Gas‐phase dissociation of 1,4‐naphthoquinone derivative anions by electrospray ionization tandem mass spectrometry
Authors: Vessecchi Ricardo , Carollo Carlos A. , Lopes José N. C. , Crotti Antonio E. M. , Lopes Norberto P. , Galembeck Sérgio E. 
Published: June 2009

AbstractGas‐phase dissociation pathways of deprotonated 1,4‐naphthoquinone (NQ) derivatives have been investigated by electrospray ionization tandem mass spectrometry (ESI‐MS/MS). The major decomposition routes have been elucidated on the basis of quantum chemical calculations at the B3LYP/6‐31 + G(d,p) level. Deprotonation sites have been indicated by analysis of natural charges and gas‐phase acidity. NQ anions underwent an interesting reaction under collision‐induced dissociation conditions, which resulted in the radical elimination of the lateral chain, in contrast with the even‐electron rule. Possible pathways have been suggested, and their mechanisms have been elucidated on the basis of Gibbs energy and enthalpy values for the anions previously described at each pathway. Copyright © 2009 John Wiley & Sons, Ltd.
Influence of rootstock and scion on antioxidant capacity of juice from new pomelo and mandarin varieties
Authors: Raveh Eran , Saban Tany , Zipi Hillman , Beit‐Yannai Elie 
Published: June 2009

AbstractBACKGROUND: New pomelo and mandarin scion varieties growing under subtropical arid conditions were investigated for total antioxidants in the juice. Four different rootstocks—sour orange (Citrus aurantium (L.); SO), Volkamer lemon (C. volkameriana (Ten & Pasq.)), SB812 (C. sunki (Hort. ex Tan.) × Poncirus trifoliate (L.)) and C. macrophylla (Wester)—were tested.RESULTS: Fruit juice was tested for total antioxidants, ascorbic acid and total polyphenol contents. Cyclic voltammetry (CV) analysis revealed three different antioxidant groups for pomelo and four groups for mandarin. CV analysis for the pomelo scion/rootstock combinations showed that ascorbic acid concentration was highest for scions grafted onto SO. Total polyphenol levels were similar among the pomelo varieties. Mandarin analysis revealed that ‘Merav’ scion/SO had the highest ascorbic acid concentration (1.91 ± 0.01 mmol L−1). Total polyphenol analysis discovered that ‘Merav’ 4/119‐/SB812 gave the highest levels, while ‘Ora Shani’ scion grafted on to any tested rootstock contained the lowestCONCLUSION: We suggest that the SO rootstock is superior to Volka, 812 and macrophylla in terms of juice antioxidant capacity. For the pomelo, both ‘Flamingo’ scions were found to have high antioxidant production capacity, with ‘Flamingo’ 3/73 being slightly superior regardless of the rootstock. The best mandarins were ‘Merav’ hybrids in combination with SO rootstock. Copyright © 2009 Society of Chemical Industry
Pediatric squamous cell carcinoma: Case report and literature review
Authors: Sidell Douglas , Nabili Vishad , Lai Chi , Cheung Gilbert , Kirsch Claudia , Abemayor Elliot 
Published: June 2009

AbstractObjectives/Hypothesis:Describe a rare pediatric malignancy. Discuss the clinical, diagnostic, and therapeutic differences between squamous cell carcinoma (SCC) of the adult and pediatric population.Study Design:Case report including a detailed radiological and histopathologic analysis and review of the literature.Methods:A case report is described from a tertiary care university hospital. Histopathologic assessment and radiological details are reviewed. A literature review of the background, incidence, disease course, and treatment options are presented.Results:This case report presents a 6‐year‐old male with a 2‐month history of an enlarging oral lesion. The patient denied dysphagia, pain, weight loss, bleeding, or loosening of the teeth. Biopsy demonstrated invasive, well‐differentiated, exophytic squamous cell carcinoma with perineural and angiolymphatic invasion. Computed tomography and magnetic resonance imaging demonstrated a 2.7 × 3.0 cm poorly marginated infiltrative mass involving the gingival aspect of the superior alveolar ridge and the adjacent bony marrow, primarily to the right of midline. Multiple small subcentimeter lymph nodes were also identified in the bilateral level II to V posterior cervical triangles bilaterally.Conclusions:Pediatric SCC of the oral cavity is indeed a rare entity; however, its presence in the pediatric population should not be ignored. This case report describes the occurrence of SCC in the oral cavity of a 6‐year‐old male patient, the youngest case ever reported, and is a reminder that a multidisciplinary approach tailored to pediatric individuals is essential to obtain clear diagnoses and appropriate treatment plans.
Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas
Authors: Sedaghat Ahmad R. , Zhang Zhe , Begum Shahnaz , Palermo Robert , Best Simon , Ulmer Karen M. , Levine Marshall , Zinreich Eva , Messing Barbara P. , Gold Dorothy , Wu Annie A. , Niparko Kevin J. , Kowalski Jeanne , Hirata Richard M. , Saunders John R. , Westra William H. , Pai Sara I. 
Published: June 2009

AbstractObjectives/Hypothesis:The human papillomavirus (HPV) has been identified as a causative factor in 20% to 25% of all head and neck squamous cell carcinomas (HNSCC). Ongoing research suggests that the presence of HPV DNA in HNSCC predicts a positive prognosis with respect to disease‐free and overall survival. However, most studies have been limited by the heterogeneity in treatment regimens and/or anatomic subsites of tumor origin. In this study, we correlate clinical outcomes with HPV status for patients with oropharyngeal carcinomas who were uniformly treated with a concurrent chemoradiation treatment protocol.Study Design:Retrospective study.Methods:Demographic and clinicopathologic parameters, including age at diagnosis, gender, race, smoking and alcohol history, tumor stage and grade, locoregional recurrence, metastatic spread, recurrence‐free survival, overall survival and disease‐specific death, were obtained from medical charts and established databases. These parameters were correlated with HPV status of the tumors established by in situ hybridization analysis.Results:HPV positivity correlated with improved clinical outcomes regarding locoregional control (P = .042), recurrence‐free survival (P = .009), overall survival (P = .017), and disease‐specific death (P = .09). Advanced T stage was a significant risk factor for recurrence and death independent of HPV status.Conclusions:In patients with oropharyngeal carcinoma uniformly treated with chemoradiation, the presence of HPV is a favorable prognostic indicator with respect to recurrence and overall survival. However, advanced T stage was an independent risk factor for recurrence and death that can to some degree offset this benefit.
Adaptive finite element approximations on nonmatching grids for second‐order elliptic problems
Authors: Chen Hongsen , Ewing Richard E. , Qin Guan 
Published: June 2009

AbstractIn this article we consider a finite element approximation for a model elliptic problem of second order on non‐matching grids. This method combines the continuous finite element method with interior penalty discontinuous Galerkin method. As a special case, we develop a finite element method that is continuous on the matching part of the grid and is discontinuous on the nonmatching part. A residual type a posteriori error estimate is derived. Results of numerical experiments are presented. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2010
Numerical study of homotopy‐perturbation method applied to Burgers equation in fluid
Authors: Ganji D.D. , Ganji S.S. , Karimpour S. , Ganji Z.Z. 
Published: June 2009

AbstractIn this article, the problem of Burgers equation is presented and the homotopy perturbation method (HPM) is employed to compute an approximation to the solution of the system of nonlinear differential equations governing on the problem. Comparison is made between the HPM and Exact solutions. The obtained solutions, in comparison with the exact solutions, admit a remarkable accuracy. A clear conclusion can be drawn from the numerical results that the HPM provides highly accurate numerical solutions for nonlinear differential equations. © 2009 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2010
Psychographic clustering of blood donors in Egypt using Kohonen's self‐organizing maps
Authors: Mostafa Mohamed M. 
Published: June 2009

AbstractBlood donation has historically been marketed as one of the purest examples of altruistic or pro‐social behavior. The recruitment of blood donors is, however, a challenge as transfusion centers worldwide strive to attract and retain blood donors. This study uses self‐organizing maps (SOM) to examine the effect of various psychographic and cognitive factors on blood donation in Egypt. SOM is a machine learning method that can be used to explore patterns in large and complex datasets for linear and nonlinear patterns. The results show that major variables affecting blood donation are related to altruistic values, perceived risks of blood donation, blood donation knowledge, attitudes toward blood donation, and intention to donate blood. The study also shows that SOM models are capable of improving clustering quality while extracting valuable information from multidimensional data.Copyright © 2009 John Wiley & Sons, Ltd.
Differential diagnosis and discussion of a large nasal neoplasm from a late Bronze Age Athenian male
Authors: Smith S. Kirkpatrick 
Published: June 2009

AbstractAn adult male from the late Bronze Age of Athens, Greece, was found to have a large neoplasm in the nasal cavity. The characteristics of the lesion suggest that it was an osteoma of the ethmoid. Secondary infections of the paranasal sinuses are present as a result of the tumour blocking the sinus drainage. Copyright © 2009 John Wiley & Sons, Ltd.
Swelling and biocompatibility of sodium alginate/poly(γ‐glutamic acid) hydrogels
Authors: Huang Mei‐Hua , Yang Ming‐Chien 
Published: June 2009

AbstractSodium alginate (Alg) hydrogel films were crosslinked with either calcium poly(γ‐glutamate) (Ca‐PGA) or CaCl2. The hydrophilicity of the resulting hydrogel films was evaluated through swelling tests, water retention capacity tests, and water vapor permeation tests. The swelling ratio, water retention capacity, and the water vapor transmission rate (WVTR) of Alg/Ca‐PGA were higher than those of Ca‐Alg. The swelling ratio of Alg/Ca‐PGA was 651 and 190% at pH 7.4 and pH 1.2, respectively. The tensile strength of Alg/Ca‐PGA hydrogel was lower than that of Ca‐Alg. The results of hemocompatibility test showed that Alg/Ca‐PGA caused shorter activated partial thromboplastin time (APTT) than Ca‐Alg. Both Ca‐Alg and Alg/Ca‐PGA exhibited almost no adsorption of human serum albumin (HSA), whereas the adsorption of human plasma fibrinogen (HPF) of Ca‐Alg was 10 times of that of Alg/Ca‐PGA. In addition, Alg/Ca‐PGA exhibited platelet adhesion higher than Ca‐Alg. Furthermore, both Alg/Ca‐PGA and Ca‐Alg exhibited no cytotoxicity. Copyright © 2009 John Wiley & Sons, Ltd.
Modification of RAFT‐polymers via thiol‐ene reactions: A general route to functional polymers and new architectures
Authors: Boyer Cyrille , Granville Anthony , Davis Thomas P. , Bulmus Volga 
Published: June 2009

AbstractAn investigation into the aminolysis of ω‐end groups of RAFT‐polymers and simultaneous thiol‐ene reactions with ene‐bearing compounds is described. Three different polymers, P(MMA), P(HPMA), and P(NIPAAm), with low PDIs were synthesized using dithiobenzoate and trithiocarbonate RAFT agents. P(NIPAAm) synthesized with trithiocarbonate RAFT agent and P(HPMA) synthesized with dithiobenzoate RAFT agent were both functionalized with a methacrylate‐modified mannose and a maleimide‐modified biotin via one‐pot simultaneous aminolysis and thiol‐ene reactions with product yields above 85%. The presence of ene‐compounds during aminolysis was shown to prevent the formation of disulfide interchain crosslinking. Using the same approach, P(MMA), P(HPMA), and P(NIPAAm) were converted to (meth)acrylate macromonomers with high yields (>80%). In the case of P(MMA), the simultaneous aminolysis and thiol‐ene addition prevented any intrachain side reactions, i.e., thiolactone formation. New architectures such as graft and block copolymers were successfully generated from the macromonomers. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3773–3794, 2009
Glaser coupling of polymers: Side‐reaction in Huisgens “click” coupling reaction and opportunity for polymers with focal diacetylene units in combination with ATRP
Authors: Duxbury Christopher J. , Cummins David , Heise Andreas 
Published: June 2009

AbstractAtom transfer radical polymerization (ATRP) was used in combination with Glaser type coupling, allowing the clean and efficient formation of symmetrically coupled polymers with a central diacetylene unit. The feasibility of the clean acetylene coupling was investigated with alkyne terminated poly(ethylene glycol) and poly(styrene) obtained by ATRP. The latter allowed subsequent ATRP to be carried out from the coupled products, offering opportunities for the formation of well defined functional materials with central diacetylene units. Glaser coupling was also observed as a side reaction in Huisgens‐type “click” reactions of polymeric alkynes with hindered surface azide groups. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3795–3802, 2009
Functionalized random copolymers from versatile one‐pot click chemistry/ATRP tandems approaches
Authors: Damiron Denis , Desorme Mylène , Ostaci Roxana‐Viorela , Al Akhrass Samer , Hamaide Thierry , Drockenmuller Eric 
Published: June 2009

AbstractTwo complementary tandem strategies based on the one‐pot combination of click chemistry and atom transfer radical polymerization (ATRP) are studied. Initially, functionalized random copolymers are obtained by copolymerization of methyl methacrylate and propargyl methacrylate simultaneously to the click chemistry coupling of a monofunctional azide. Then, an approach based on the copolymerization of methyl methacrylate and 11‐azido‐undecanoyl methacrylate simultaneously to the click chemistry coupling of a monofunctional alkyne is also investigated. For both the approach, polymerization and click chemistry coupling are catalyzed by CuBr and bipyridine (Bipy) in diphenylether at 90 °C. The [Bipy]/[CuBr] ratio is varied from 2 to 25 and the ratio of functionalized comonomer from 20 to 70 mol %. Both the tandem strategies proceed with good yields (50–80%) and allow a good control over the characteristics of the resulting random copolymers and macromolecular brushes (Mn ∼ 15,000–40,000 g/mol and PDI ∼ 1.3–2.0) as well as quantitative click functionalization as characterized by 1H NMR and size exclusion chromatography analyses. Although the click process is generally completed at the early stage of the process, the rate of polymerization depends on the amount of bipyridine involved. It was found that extending most of the polymerization process out of the click reaction regime results in a better control of the polymerization, preventing the significant occurrence of side reactions. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3803–3813, 2009
“Living” radical polymerization of styrene catalyzed by cyclometalated ruthenium(II) complexes bearing nonlabile ligands
Authors: Aguilar‐Lugo C. , Le Lagadec R. , Ryabov Alexander D. , Valverde G. Cedillo , Morales S. Lopez , Alexandrova L. 
Published: June 2009

AbstractCationic substitutionally inert cyclometalated ruthenium (II) and osmium (II) complexes, ([Mt(o‐C6H4‐2‐py)(LL)2]PF6), where LL‐1,10‐phenanthroline (phen) or 2,2′‐bipyridine (bipy), were used for radical polymerization of styrene. Gradual modification of the complexes within the series allowed comparison of the catalytic activity and the redox properties. There was no correlation between the reducing powers of the complexes and their catalytic activities. The osmium compound of the lowest reduction potential was not active. All the ruthenium complexes catalyzed the polymerization of styrene in a controlled manner; but the level of control and the catalytic activity were different under the same polymerization conditions. [Ru(o‐C6H4‐2‐py)(phen)2]PF6 demonstrated the best catalytic performance though its redox potential was the highest. It catalyzed the “living” polymerization with a reasonable rate at a catalyst‐to‐initiator ratio of 0.1. 1 equiv. of Al(OiPr)3 accelerated the polymerization and improved the control, but higher amount of Al(OiPr)3 did not speed up the polymerization and moved the process into the uncontrollable regime. Under the most optimal conditions, the controlled polymerization occurs fast without any additive and the catalyst degradation. Added free ligands inhibited the polymerization suggesting that the catalytically active ruthenium intermediates are generated via the reversible dechelation of bidentate phen or bipy ligands. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3814–3828, 2009