bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes
Authors: Li Qin , Yang Zhen , Lu Bin , Wen Jie , Ye Zi , Chen Lili , He Min , Tao Xiaoming , Zhang Weiwei , Huang Ying , Zhang Zhaoyun , Qu Shen , Hu Renming 
Published: August 2011

Abstract

Objective
We aimed to investigate whether elevated serum uric acid concentrations are associated with higher risk of metabolic syndrome (MetS) and carotid atherosclerosis in patients with type 2 diabetes.

Methods
We conducted a population-based cross-sectional survey in Shanghai, with a total of 395 men and 631 women age 41 to 92 years. The carotid artery intima-media thickness (IMT) and carotid atherosclerotic plaques (PLQ) were measured by B-mode ultrasound. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.

Results
Uric acid levels were negatively associated with duration of diabetes, fasting plasma glucose, glycohemoglobin, eGFR, HDL-cholesterol (all P < 0.001) and positively with BMI, CRP, waist circumference, triglycerides, systolic blood pressure, ACR, HOMA-IR and IMT (all P < 0.05). In the highest quartile of uric acid levels, the risks were substantially higher for MetS [odds ratio 3.97, (95% confidence interval 2.58-6.13)] (P < 0.001 for trend) and PLQ [odds ratio 2.71 (95% confidence interval 1.62-4.47)] (p = 0.013 for trend) compared with that in the lowest quartile of uric acid levels after multiple adjustment. These associations remained significant after further adjustment for potential confounders.

Conclusions
Serum uric acid level is associated with MetS and is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.
GPIHBP1 C89F Neomutation and Hydrophobic C-Terminal Domain G175R Mutation in Two Pedigrees with Severe Hyperchylomicronemia
Authors: Charrière Sybil , Peretti Noël , Bernard Sophie , Di Filippo Mathilde , Sassolas Agnès , Merlin Micheline , Delay Mireille , Debard Cyrille , Lefai Etienne , Lachaux Alain , Moulin Philippe , Marçais Christophe 
Published: August 2011

Abstract

Context:
GPIHBP1 is a new endothelial binding site for lipoprotein lipase (LPL), the key enzyme for intravascular lipolysis of triglyceride-rich lipoproteins (TGRL). We have identified two new missense mutations of the GPIHBP1 gene, C89F and G175R, by systematic sequencing in a cohort of 376 hyperchylomicronemic patients without mutations on the LPL, APOC2, or APOA5 gene.

Objective:
Phenotypic expression and functional consequences of these two mutations were studied.

Design:
We performed clinical and genotypic studies of probands and their families. GPIHBP1 functional alterations were studied in CHO pgsA-745 transfected cells.

Results:
Probands are an adult with a homozygous G175R mutation and a child with a hemizygous C89F neomutation and a deletion of the second allele. C89F mutation was associated with a C14F signal peptide polymorphism on the same haplotype. Both patients had resistant hyperchylomicronemia, low LPL activity, and history of acute pancreatitis. In CHO pgsA-745 cells, both G175R and C14F variants reduce the expression of GPIHBP1 at the cell surface. C89F mutation is responsible for a drastic LPL-binding defect to GPIHBP1. C14F may further potentiate C89F effect.

Conclusions:
The emergence of hyperchylomicronemia in the generation after a neomutation further establishes a critical role for GPIHBP1 in TGRL physiopathology in humans. Our results highlight the crucial role of C65-C89 disulfide bond in LPL binding by GPIHBP1 Ly6 domain. Furthermore, we first report a mutation of the hydrophobic C-terminal domain that impairs GPIHBP1 membrane targeting.
Mortality from pulmonary embolism is decreasing in hospital patients
Authors: Kopcke Douglas , Harryman Ondina , Benbow Emyr W , Hay Charles , Chalmers Nicholas 
Published: August 2011

Objectives Pulmonary embolism is believed to be a common cause of death of hospital inpatients. The aims of this study were to estimate the number of deaths caused by pulmonary embolism and the potential to reduce this by the use of caval filters according to accepted indications. Design Review of autopsy reports and death notification records from 2007 and 2008. When pulmonary embolism was given as cause of death (in the autopsy report or in section 1 a-c or part 2 of the Medical Certificate of the Cause of Death), hospital records were reviewed for evidence of pre-mortem diagnosis of pulmonary embolism or deep vein thrombosis (DVT) and for evidence of accepted indications for caval filter placement. Setting Large UK teaching hospital. Participants Hospital inpatients whose deaths were attributed to pulmonary embolism. Main outcome measures Proportion of deaths adjudged at autopsy to be due to pulmonary embolism; evidence of pre-mortem diagnosis of DVT or pulmonary embolism; total number of hospital admission and deaths. Results From a total of 186,517 adult inpatient admissions there were 2583 (1.4%) adult inpatient deaths of which 696 (27%) underwent autopsy. Of those undergoing autopsy, 14 (2.0%, 95% CI 1.2–3.3%) deaths were caused by pulmonary embolism. Pulmonary embolism was recorded as a cause of death in a further 12 (0.7%) of 1773 patients who did not undergo autopsy. Of these, five had a pre-mortem diagnosis of DVT or pulmonary embolism. Conclusions The proportion of deaths caused by pulmonary embolism appears to be considerably lower than the widely published rate, and of this small number, few have a pre-mortem diagnosis of DVT or pulmonary embolism. There is little scope for further reduction of pulmonary embolism mortality through use of caval filters according to guidelines. Current policy on pulmonary embolism risk prevention appears to be based on an over-estimate of the level of risk.
The utility of six over-the-counter (home) pregnancy tests
Authors: Cole Laurence A. 
Published: August 2011

Abstract

Background: The home pregnancy market is rapidly evolving. It has moved from detection of pregnancy on the day of missed menstrual bleeding, to detection claims 4 days prior. It is moving from all manual tests to digital tests, with a monitor reading the bands and informing women they are pregnant. A thorough study is needed to investigate the validity of claims and evolving usefulness of devices.

Methods: Studies were proposed to examine the sensitivity and specificity of home tests and their abilities to detect pregnancy. Methods examined the abilities of tests to detect human chorionic gonadotropin (hCG), hyperglycosylated hCG, free β-subunit, a mixture of these antigens in 40 individual early pregnancy urines.

Results: Using a mixture of hCG, hyperglycosylated hCG and free β-subunit typical for early pregnancy, the sensitivity of the First Response manual and digital tests was 5.5 mIU/mL, while the sensitivities of the EPT and ClearBlue brand manual and digital tests was 22 mIU/mL. On further evaluation, the First Response manual and digital tests both detected 97% of 120 pregnancies on the day of missed menstrual bleeding. The EPT manual and digital devices detected 54% and 67% of pregnancies, respectively, and the ClearBlue manual and digital devices detected 64% and 54% of pregnancies, respectively.

Conclusions: First Response manual and digital claim >99% detection on the day of missed menses. The results here suggest similar sensitivity for these two tests. The EPT and ClearBlue manual and digital test make similar >99% claims, the data presented here disputes their elevated claim.
Electrical and Structural Characterization of the Interface of Wafer Bonded InP/Si
Authors: Morral A. Fontcuberta i , Zahler J. M. , Atwater Harry A. , Frank M. M. , Chabal Y. J. , Ahrenkiel P. , Wanlass M. 
Published: August 2011

AbstractA study of the interfacial properties of wafer bonded InP/Si is presented. The electrical properties are measured by bonding InP to Si with different doping concentrations and by measuring the current voltage characteristics of the bonded pairs. Two different kinds of structures are studied: 1) n+InP doped to 3×1018 cm-3 bonded with n+Si doped to 1×1019 cm-3, and 2) n+InP doped to 3×1018 cm-3 bonded with p-Si doped to 6×1014 cm-3. After a 350°C anneal, structure 1 shows low resistive ohmic behavior while structure 2 is rectifying due to its higher sensitivity to interfacial chemistry. Indeed, both the reverse and forward current are reduced by annealing in structure 2, suggesting the formation of an interfacial barrier during annealing. This hypothesis is supported by High Resolution Transmission Electron Microscopy combined with Fourier Transform Infrared Spectroscopy, which indicate the formation of an amorphous interfacial oxide from the reaction of adsorbed water trapped at the InP/Si interface.
Photo-Polymer Wafer Bonding for Double Layer Transfer
Authors: Loryuenyong Vorrada , Sands Tim , Cheung Nathan W. 
Published: August 2011

AbstractTemporary bonding is necessary for the two-stage transfer of thin films from one substrate to another while preserving the original orientation of the film. The process developed in this study uses an SU-8 photo-polymer both as a bonding material and as a delamination material for layer transfer. SU-8 was spun onto an optically transparent handle wafer (e.g., quartz or glass) and then bonded to the layer to be transferred. The processing parameters such as pre-baking temperature and UV exposure dose affect the bonding strength. UV curing of the SU-8 through the backside of the handle wafer could be performed to obtain the ultimate bond strength at low temperatures. A laser pulse from a KrF excimer laser (λ = 248 nm and λ = 38 ns) at a fluence of 50-150 mJ/cm2 was used to delaminate the SU-8 bonding layer to complete the layer transfer.
Determining Current Physical Therapist Management of Hip Fracture in an Acute Care Hospital and Physical Therapists' Rationale for This Management
Authors: Thomas Susie , Mackintosh Shylie , Halbert Julie 
Published: August 2011

Background
Physical therapy has an important role in hip fracture rehabilitation to address issues of mobility and function, yet current best practice guidelines fail to make recommendations for specific physical therapy interventions beyond the first 24 hours postsurgery.

Objectives
The aims of this study were: (1) to gain an understanding of current physical therapist practice in an Australian acute care setting and (2) to determine what physical therapists consider to be best practice physical therapist management and their rationale for their assessment and treatment techniques.

Design and Methods
Three focus group interviews were conducted with physical therapists and physical therapist students, as well as a retrospective case note audit of 51 patients who had undergone surgery for hip fracture.

Results
Beyond early mobilization and a thorough day 1 postoperative assessment, great variability in what was considered to be best practice management was displayed. Senior physical therapists considered previous clinical experience to be more important than available research evidence, and junior physical therapists modeled their behavior on that of senior physical therapists. The amount of therapy provided to patients during their acute inpatient stay varied considerably, and none of the patients audited were seen on every day of their admission.

Conclusions
Current physical therapist management in the acute setting for patients following hip fracture varies and is driven by system pressures as opposed to evidence-based practice.
Effects on Vision With Glare After Correction of Monochromatic Wavefront Aberrations
Authors: Jungnickel Hendrik , Babovsky Holger , Kiessling Armin , Gebhardt Michael , Grein Hans-Juergen , Kowarschik Richard 
Published: August 2011

PURPOSE:
To investigate effects of optical aberration correction on vision with glare.

METHODS:
Correction of aberrations up to the 6th Zernike order (closed-loop correction) was compared with conventional spectacle correction in 42 healthy eyes. To create these corrections, an adaptive optics system including a thin-film transistor (TFT) monitor for displaying optotypes with additional glare sources was used. Employing both corrections, visual acuity and contrast sensitivity (CS) were tested alternately with and without glare. Disability glare was computed as the difference between log CS without and with glare. Individuals were also asked to rate subjectively the quality of three images displayed on the TFT monitor.

RESULTS:
Significant improvements of CS without and with glare were found with the closed-loop correction (0.147 and 0.198 log CS, respectively), whereas no significant difference in visual acuity was found in either correction. Correlations were determined between reduction of total root-mean-square error and increase of CS with glare (Pearson correlation coefficient r=0.42) and decrease of disability glare (r=−0.33). Visual acuity was correlated with the visual Strehl ratio based on the optical transfer function (r=0.46). Subjective comparison of the images showed improvements more clearly. Depending on the image, in 57% to 78% of the eyes, closed-loop correction was rated better than spectacle correction. The subjective glare effect was reduced as well.

CONCLUSIONS:
Investigation of vision with glare seems to be a reasonable additional test to evaluate the visual outcome of a customized correction.
Functionalization of the 3‐Position of Thiophene and Benzo[b]thiophene Moieties by Palladium‐Catalyzed CC Bond Forming Reactions using Diazonium Salts
Authors: Raduán Mónica , Padrosa Joaquim , Pla‐Quintana Anna , Parella Teodor , Roglans Anna 
Published: August 2011

AbstractThe palladium‐catalyzed Matsuda–Heck and Suzuki–Miyaura cross‐couplings of 2‐methoxycarbonylthiophene‐3‐diazonium tetrafluoroborate 1 were performed to synthesize a series of thiophene derivatives functionalized in the β‐position. Good to excellent yields of the cross‐coupling products were obtained using palladium acetate [Pd(OAc)2], a ligandless palladium catalyst, without a base, at room temperature, under aerobic conditions and with short reaction times. A diazotization and cross‐coupling sequence can also be performed in a one‐pot process avoiding the isolation of the thiophenediazonium salt derivative. In addition, 2‐methoxycarbonylbenzo[b]thiophene‐3‐diazonium tetrafluoroborate 8 was also efficiently arylated by applying the same Suzuki–Miyaura optimized reaction conditions.
Intramolecular Oxidation of the Alcohol Functionalities in Hydroxyalkyl‐N‐Heterocyclic Carbene Complexes of Iridium and Rhodium
Authors: Benítez Miriam , Mas‐Marzá Elena , Mata José A. , Peris Eduardo 
Published: August 2011

AbstractA series of hydroxyalkyl‐functionalized imidazolium salts have been coordinated to Rh and Ir to afford the corresponding MCp*–(NHC) (Cp*=pentamethylcyclopentadienyl) complexes. The reactivity of the new complexes has been studied with special attention to the transformations that deal with the alcohol functionality. The metal‐mediated intramolecular transformations allowed the formation of several products that resulted from the oxidation of the alcohols to aldehydes and esters. All the new complexes have been fully characterized, and the crystal structures of the most representative complexes have been resolved.
ChemInform Abstract: High‐Temperature Behavior and Polymorphism in Novel Members of the Perovskite Family Pb2LnSbO6 (Ln: Ho, Er, Yb, Lu).
Authors: Larregola Sebastian A. , Alonso Jose A. , Sheptyakov Denis , Alguero Miguel , Munoz Angel , Pomjakushin Vladimir , Pedregosa Jose C. 
Published: August 2011

AbstractThe title compounds are prepared by solid state reactions of PbO, Ln2O3, and Sb2O3 (1.
ChemInform Abstract: Complex Nanoscale Cage Clusters Built from Uranyl Polyhedra and Phosphate Tetrahedra.
Authors: Unruh Daniel K. , Ling Jie , Qiu Jie , Pressprich Laura , Baranay Melissa , Ward Matthew , Burns Peter C. 
Published: August 2011

AbstractCrystals of Ba15 [(UO2)30(O2)30(OH)30] (I), (K,Li)42 [(UO2)42(O2)42(OH)42] (II), (K,Li)51 [(UO2)30(O2)30 (P2O7)12(PO4) (H2O)5] (III), (K,Li)48 [(UO2)42(O2)42(OH)36 (P2O7)3](H2O)92 (IV), and (K,Li)42 [(UO2)30(O2)39 (P2O7)6] (V) are obtained from aqueous alkaline solutions containing UO2(NO3)2 and H2O2.
ChemInform Abstract: Molecular Growth of a Core—Shell Polyoxometalate.
Authors: Fang Xikui , Koegerler Paul , Furukawa Yuji , Speldrich Manfred , Luban Marshall 
Published: August 2011

AbstractCompound (IV) crystallizes in the triclinic space group P$\bar 1$ with Z = 2 (single crystal XRD).
ChemInform Abstract: Iridium‐Catalyzed anti‐Diastereo‐ and Enantioselective Carbonyl (α‐Trifluoromethyl)allylation from the Alcohol or Aldehyde Oxidation Level.
Authors: Gao Xin , Zhang Yong Jian , Krische Michael J. 
Published: August 2011

AbstractThe title reaction of allyl benzoate (I) with primary alcohols efficiently proceeds in the presence of a base and a stoichiometric amount of water to suppress transesterification.
ChemInform Abstract: Enantioselective Epoxide Ring Opening Catalyzed by Bis(tetrahydroisoquinoline) N,N′‐Dioxides.
Authors: Kadlcikova Aneta , Vlasana Klara , Kotora Martin 
Published: August 2011

AbstractTwo earlier synthesized (compounds Ia) and two novel (compounds Ib) axially chiral N‐oxide catalysts are tested in the ring opening of epoxides.
ChemInform Abstract: Palladium‐Supported Ionic Liquid Catalyst (Pd‐SH‐SILC) Immobilized on Mercaptopropyl Silica Gel as a Chemoselective, Reusable and Heterogeneous Catalyst for Catalytic Hydrogenation.
Authors: Hagiwara Hisahiro , Nakamura Tomomi , Hoshi Takashi , Suzuki Toshio 
Published: August 2011

AbstractA novel heterogeneous palladium catalyst is prepared and successfully applied in the chemoselective hydrogenation of a variety of unsaturated substrates.
ChemInform Abstract: Direct Arylation of Heteroarenes Catalyzed by a Palladium—1,10‐Phenanthroline Complex.
Authors: Takita Ryo , Fujita Daichi , Ozawa Fumiyuki 
Published: August 2011

AbstractThe arylation of thiophene, furan, and indole derivatives is conducted by using palladium acetate and phenanthroline as catalyst precursors.
ChemInform Abstract: Preparation of Alkyl Formates from Corresponding Alcohols Using Ethyl Formate Catalyzed by Poly(4‐vinylpyridinium tribromide) under Neutral and Solvent‐Free Conditions.
Authors: Ghorbani‐Choghamarani Arash , Norouzi Masoomeh 
Published: August 2011

AbstractThe advantages of the procedure are avoidance of metallic and acidic catalysts, organic solvents, corrosive and toxic reagents and operational simplicity.
ChemInform Abstract: Direct Synthesis of Ester‐Containing Indium Homoenolate and Its Application in Palladium‐Catalyzed Cross‐Coupling with Aryl Halide.
Authors: Shen Zhi‐Liang , Goh Kelvin Kau Kiat , Wong Colin Hong An , Yang Yong‐Sheng , Lai Yin‐Chang , Cheong Hao‐Lun , Loh Teck‐Peng 
Published: August 2011

AbstractThe synthesis of ester‐containing indium homoenolates via a direct insertion of indium into ω‐halo esters (I) or ‐ketones (IV) in the presence of CuI/LiCl is described.
ChemInform Abstract: NbCl3‐Catalyzed Three‐Component [2 + 2 + 2] Cycloaddition Reaction of Terminal Alkynes, Internal Alkynes, and Alkenes to 1,3,4,5‐Tetrasubstituted 1,3‐Cyclohexadienes.
Authors: Satoh Yasushi , Obora Yasushi 
Published: August 2011

AbstractThe title reaction allows an efficient and highly regioselective access to 1,3,4,5‐tetrasubstituted cyclohexadienes.
ChemInform Abstract: Copper‐Mediated Methylthiolation of Aryl Halides with DMSO.
Authors: Luo Fang , Pan Changduo , Li Liping , Chen Fan , Cheng Jiang 
Published: August 2011

AbstractA Cu‐mediated methylthiolation of aryl halides (I) with DMSO (II) as terminal methylthiolation source is developed.
ChemInform Abstract: Synthesis and Structure—Activity Relationships of a Novel Class of Dithiocarbamic Acid Esters as Anticancer Agent.
Authors: Hou Xueling , Ge Zemei , Wang Tingmin , Guo Wei , Wu Jun , Cui Jingrong , Lai Chingsan , Li Runtao 
Published: August 2011

AbstractA series of new dithiocarbamates [cf.
ChemInform Abstract: Synthesis of Substituted 3‐Iodopyrroles by Cycloisomerization of Propargylic Aziridines with Iodine.
Authors: Yoshida Masahiro , Easmin Salina , Al‐Amin Mohammad , Hirai Yuuki , Shishido Kozo 
Published: August 2011

AbstractIn the case of N‐tosyl‐substituted substrates, the title cycloisomerization requires a platinum catalyst to promote the reaction.
ChemInform Abstract: Intramolecular Oxidative C—N Bond Formation for the Synthesis of Carbazoles: Comparison of Reactivity Between the Copper‐Catalyzed and Metal‐Free Conditions.
Authors: Cho Seung Hwan , Yoon Jungho , Chang Sukbok 
Published: August 2011

AbstractThe carbazole synthesis from N‐substituted amidobiphenyls is facilitated by combined use of a copper catalyst and an idodine(III) species.
ChemInform Abstract: Atom‐Economical Synthesis of 2‐Aminoimidazoles via [3 + 2] Annulation Catalyzed by Titanacarborane Monoamide.
Authors: Wang Yang , Shen Hao , Xie Zuowei 
Published: August 2011

AbstractThe reaction of propargylamines (I), (IV), and (VI) with carbodiimides (II) in the presence of the title catalyst affords a new class of substituted aminoimidazoles in good to high yields.
ChemInform Abstract: Modular Synthesis of Triazole‐Containing Triaryl α‐Helix Mimetics.
Authors: Ehlers Ina , Maity Prantik , Aube Jeffrey , Koenig Burkhard 
Published: August 2011

AbstractThree different scaffold types are synthesized that mimic the geometric arrangement of side chains in an α‐helical peptide.
ChemInform Abstract: Cascade Reaction of β,γ‐Unsaturated α‐Ketoesters with Phenols in Trityl Chloride/TFA System. Highly Selective Synthesis of 4‐Aryl‐2H‐chromenes and Their Applications.
Authors: Wu Yan‐Chao , Li Hui‐Jing , Liu Li , Liu Zhe , Wang Dong , Chen Yong‐Jun 
Published: August 2011

AbstractTrityl chloride—TFA‐promoted reaction of β,γ‐unsaturated α‐ketoesters (II) with a variety of phenols (I), (X) and (XII) proceeds efficiently to afford title arylchromenes (III), (XI) and (XIII), resp., in high yields.
ChemInform Abstract: Rapid Access to H‐Pyrazolo[5,1‐a]isoquinolines via Sequential Reaction of N′‐(2‐Alkynylbenzylidene)hydrazides.
Authors: Chen Zhiyuan , Pan Xiaolin , Wu Jie 
Published: August 2011

AbstractA one‐pot sequential reaction between N‐(alkynylbenzylidene)hydrazide (I), bromine, α,β‐unsaturated aldehydes (II), and methanol (III) generates the pyrazoloisoquinolines (IV) under mild conditions in moderate to good yields.
ChemInform Abstract: Enantioselective Rhodium‐Catalyzed [4 + 2] Cycloaddition of α,β‐Unsaturated Imines and Isocyanates.
Authors: Oberg Kevin M. , Rovis Tomislav 
Published: August 2011

AbstractThe title reaction allows the synthesis of pyrimidinones such as (III) possessing a substitution pattern complementary to that of Biginelli adducts.
ChemInform Abstract: Enantioselective Copper‐Catalyzed O—H Insertion of α‐Diazo Phosphonates.
Authors: Zhu Shou‐Fei , Chen Wang‐Qiao , Zhang Qian‐Qian , Mao Hong‐Xiang , Zhou Qi‐Lin 
Published: August 2011

AbstractThe asymmetric O—H insertion of α‐diazo phosphonates with alcohols in the presence of a catalyst, generated in situ from a Cu(I) precursor, a chiral spiro bisoxazoline ligand and a sodium borate, provides good yields of α‐alkoxy phosphonates with high enantioselectivities.
ChemInform Abstract: The Introduction of a Double Bond on the Steroid Skeleton — The Preparation of Enol Silyl Ether Derivatives from Vicinal Diols.
Authors: Marek Ales , Klepetarova Blanka , Elbert Tomas 
Published: August 2011

AbstractConditions for the transformation of a 2,3‐diol group of common brassinosteroids to a 2,3‐bis(silyloxy) enol group, a suitable precursor for regio‐ and stereoselective labelling reactions, are established.
ChemInform Abstract: Hirsutosterols A—G, Polyoxygenated Steroids from a Formosan Soft Coral Cladiella hirsuta.
Authors: Chen Bo‐Wei , Chang Shu‐Ming , Huang Chiung‐Yao , Su Jui‐Hsin , Wen Zhi‐Hong , Wu Yang‐Chang , Sheu Jyh‐Horng 
Published: August 2011

Abstractisolation and structure elucidation of hirsutosterols A (Ia), B (Ib), C (Ic), D (IIa), E (IIb), F (IIc), and G (III), promising cytotoxic activity of hirsutosterol A (Ia) against several cancer cell lines