bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities in the accuracy of reporting opioid overdoses to 9-1-1 by race and sex of overdose victim, Marion County, Indiana, 2011–2020
Authors: Atkins Danielle N. , del Pozo Brandon , Clark MH , Andraka-Christou Barbara , O’Donnell Daniel , Ray Bradley 
Published: May 2024

Abstract
Objectives
To assess the prevalence of emergency medical incidents wherein naloxone was administered but overdose was not described as the chief complaint during the 9-1-1 call, including differences by overdose victim race/ethnicity and sex.

Methods
We computed the percentage of 9-1-1 calls in Marion County, Indiana, from 2011 to 2020, wherein naloxone was administered but the caller did not describe overdose as the chief complaint. We estimated a logistic regression to examine the associations between reporting of overdose as the chief complaint and race and sex of the overdose victim.

Results
Almost one-fifth of 9-1-1 calls preceding naloxone administration did not describe overdose as the chief complaint. 9-1-1 callers were more likely to describe a non-overdose as the chief complaint when the overdose victim was Black or female.

Conclusion
9-1-1 callers are less likely to use terminology describing overdose when the overdose victim is female or Black, than when the victim is male or White. Inaccurate terminology when calling 9-1-1 could delay naloxone administration, thereby increasing risk of overdose death and hypoxic brain injury. Some 9-1-1 callers may be avoiding overdose terminology to prevent a police response, or due to lack of knowledge about overdose identification, but further research is needed to determine the mechanisms underlying these findings.
FGL1 and FGL2: emerging regulators of liver health and disease
Authors: Chen Jiongming , Wu Lei , Li Yongsheng 
Published: May 2024

AbstractLiver disease is a complex group of diseases with high morbidity and mortality rates, emerging as a major global health concern. Recent studies have highlighted the involvement of fibrinogen-like proteins, specifically fibrinogen-like protein 1 (FGL1) and fibrinogen-like protein 2 (FGL2), in the regulation of various liver diseases. FGL1 plays a crucial role in promoting hepatocyte growth, regulating lipid metabolism, and influencing the tumor microenvironment (TME), contributing significantly to liver repair, non-alcoholic fatty liver disease (NAFLD), and liver cancer. On the other hand, FGL2 is a multifunctional protein known for its role in modulating prothrombin activity and inducing immune tolerance, impacting viral hepatitis, liver fibrosis, hepatocellular carcinoma (HCC), and liver transplantation. Understanding the functions and mechanisms of fibrinogen-like proteins is essential for the development of effective therapeutic approaches for liver diseases. Additionally, FGL1 has demonstrated potential as a disease biomarker in radiation and drug-induced liver injury as well as HCC, while FGL2 shows promise as a biomarker in viral hepatitis and liver transplantation. The expression levels of these molecules offer exciting prospects for disease assessment. This review provides an overview of the structure and roles of FGL1 and FGL2 in different liver conditions, emphasizing the intricate molecular regulatory processes and advancements in targeted therapies. Furthermore, it explores the potential benefits and challenges of targeting FGL1 and FGL2 for liver disease treatment and the prospects of fibrinogen-like proteins as biomarkers for liver disease, offering insights for future research in this field.
Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies
Authors: Plug Bonnie C. , Revers Ilma M. , Breur Marjolein , González Gema Muñoz , Timmerman Jaap A. , Meijns Niels R.C. , Hamberg Daniek , Wagendorp Jikke , Nutma Erik , Wolf Nicole I. , Luchicchi Antonio , Mansvelder Huibert D. , van Til Niek P. , van der Knaap Marjo S. , Bugiani Marianna 
Published: May 2024

AbstractHuman brain experimental models recapitulating age- and disease-related characteristics are lacking. There is urgent need for human-specific tools that model the complex molecular and cellular interplay between different cell types to assess underlying disease mechanisms and test therapies. Here we present an adapted ex vivo organotypic slice culture method using human post-mortem brain tissue cultured at an air-liquid interface to also study brain white matter. We assessed whether these human post-mortem brain slices recapitulate the in vivo neuropathology and if they are suitable for pathophysiological, experimental and pre-clinical treatment development purposes, specifically regarding leukodystrophies. Human post-mortem brain tissue and cerebrospinal fluid were obtained from control, psychiatric and leukodystrophy donors. Slices were cultured up to six weeks, in culture medium with or without human cerebrospinal fluid. Human post-mortem organotypic brain slice cultures remained viable for at least six weeks ex vivo and maintained tissue structure and diversity of (neural) cell types. Supplementation with cerebrospinal fluid could improve slice recovery. Patient-derived organotypic slice cultures recapitulated and maintained known in vivo neuropathology. The cultures also showed physiologic multicellular responses to lysolecithin-induced demyelination ex vivo, indicating their suitability to study intrinsic repair mechanisms upon injury. The slice cultures were applicable for various experimental studies, as multi-electrode neuronal recordings. Finally, the cultures showed successful cell-type dependent transduction with gene therapy vectors. These human post-mortem organotypic brain slice cultures represent an adapted ex vivo model suitable for multifaceted studies of brain disease mechanisms, boosting translation from human ex vivo to in vivo. This model also allows for assessing potential treatment options, including gene therapy applications. Human post-mortem brain slice cultures are thus a valuable tool in preclinical research to study the pathomechanisms of a wide variety of brain diseases in living human tissue.
“That’s just the way it is”: bullying and harassment in STEM academia
Authors: Corbett Estelle , Barnett Julie , Yeomans Lucy , Blackwood Leda 
Published: May 2024

Abstract
Background
The under-representation of women and other minority group members in STEM (Science, Technology, Engineering, and Mathematics) academia is a problem internationally and is attributed in part to hostile workplace cultures. We draw on the social identity perspective to examine the dynamic inter and intragroup processes entailed in these experiences. In this paper, we report a reflexive thematic analysis of 219 responses to a free-text question on bullying and harassment embedded in a national survey of 40 STEM departments from across the United Kingdom. Most were women (53%) at an early, pre-lectureship career stage.

Main findings
Our analysis shows who is the perpetrator and who is the victim is not arbitrary, and neither is the form that it takes; majority group members draw on discourses that warrant the exclusion of minority group members (e.g., women are not smart; incompatibility with religious identity). In this ‘othering’, minority group members learn that one is not regarded as a bona fide STEM academic ingroup member and accordingly are constrained in being able to claim and act on that identity. Thus, it is not just the acts themselves that are problematic, but the ways in which being denied a shared STEM academic identity is consequential for a range of putative benefits and leads to a range of strategies that all confer costs.

Conclusions/potential implications
The solution must rest with senior STEM academics and with institutions. First, we need to challenge discourses and practices that narrowly define the boundaries and content of STEM academic identity. Second, all members of a community need to perceive an alignment between the purported values of an organisation for diversity, inclusion, and respect and how that organisation responds when those principles are violated. Formal processes of remedy need to recognise the dynamics entailed in status differences and remove the onus of complaint from isolated, low status individuals. In addition, there is a need to recognise the ways in which perpetrators are embedded in networks of support both within and without the university; and the importance, therefore, of widening the scope of evidence gathering and intervention.
Tablet-based Augmented reality and 3D printed templates in fully guided Microtia Reconstruction: a clinical workflow
Authors: Díez-Montiel Alberto , Pose-Díez-de-la-Lastra Alicia , González-Álvarez Alba , Salmerón José I. , Pascau Javier , Ochandiano Santiago 
Published: May 2024

Abstract
Background
Microtia is a congenital malformation of the auricle that affects approximately 4 of every 10,000 live newborns. Radiographic film paper is traditionally employed to bidimensionally trace the structures of the contralateral healthy ear in a quasi-artistic manner. Anatomical points provide linear and angular measurements. However, this technique proves time-consuming, subjectivity-rich, and greatly dependent on surgeon expertise. Hence, it’s susceptible to shape errors and misplacement.

Methods
We present an innovative clinical workflow that combines 3D printing and augmented reality (AR) to increase objectivity and reproducibility of these procedures. Specifically, we introduce patient-specific 3D cutting templates and remodeling molds to carve and construct the cartilaginous framework that will conform the new ear. Moreover, we developed an in-house AR application compatible with any commercial Android tablet. It precisely guides the positioning of the new ear during surgery, ensuring symmetrical alignment with the healthy one and avoiding time-consuming intraoperative linear or angular measurements. Our solution was evaluated in one case, first with controlled experiments in a simulation scenario and finally during surgery.

Results
Overall, the ears placed in the simulation scenario had a mean absolute deviation of 2.2 ± 1.7 mm with respect to the reference plan. During the surgical intervention, the reconstructed ear was 3.1 mm longer and 1.3 mm wider with respect to the ideal plan and had a positioning error of 2.7 ± 2.4 mm relative to the contralateral side. Note that in this case, additional morphometric variations were induced from inflammation and other issues intended to be addressed in a subsequent stage of surgery, which are independent of our proposed solution.

Conclusions
In this work we propose an innovative workflow that combines 3D printing and AR to improve ear reconstruction and positioning in microtia correction procedures. Our implementation in the surgical workflow showed good accuracy, empowering surgeons to attain consistent and objective outcomes.
Navigating uterine niche 360 degree: a narrative review
Authors: Zakherah Mahmoud , Mohamed Ahmed A. , Rageh Abdulrahman M. , Abdel-aleem Mahmoud 
Published: May 2024

Abstract
Background
The increasing prevalence of cesarean section (CS) deliveries globally has sparked apprehension regarding potential long-term complications, notably the emergence of uterine niches. CS results in a scar that in certain patients, inadequate healing of that scar results in the development of a uterine niche. While most small niches show no symptoms, large cesarean scar niches in nonpregnant women can give rise to cesarean scar disorder syndrome. This syndrome is characterized by abnormal uterine bleeding, dysmenorrhea, and secondary infertility. In pregnant women, the presence of substantial niches may be linked to potentially life-threatening complications, including cesarean scar dehiscence, uterine rupture, placenta accreta spectrum disorders, placenta previa, and cesarean scar ectopic pregnancy.

Main body
Given the potential dangers associated with uterine niche occurrence, numerous studies in recent years have delved into the concept of cesarean scar niche, exploring its risk factors, diagnostic approaches, and treatment options. Various diagnostic modalities, such as two- or three-dimensional transvaginal ultrasonography, two- and three-dimensional sono-hysterography, hysterosalpingography, hysteroscopy, or magnetic resonance imaging, can be employed to detect uterine niches. However, none of these diagnostic methods is universally accepted as the “gold standard,” and there remains a lack of unequivocal guidelines on certain aspects related to the diagnosis of cesarean scar niche. These niches, characterized by hypoechoic regions within the myometrium at the site of a previous CS scar, pose diagnostic complexities and provoke inquiries into their prevalence, factors influencing their development, clinical presentations, and appropriate therapeutic approaches.

Conclusion
As CS rates rise, this review aims to understand and address uterine niches and mitigate their impact on maternal health and reproductive outcomes.
Evaluation of ivabradine plus beta-blocker versus beta-blocker alone in addition to standard care in reducing hospitalization and major adverse cardiovascular event in patients with chronic heart failure: a prospective observational study in tertiary care hospital in central India
Authors: Desingu Ramyaa , Kaore Shilpa , Kandelwal Gaurav , Balakrishnan S. 
Published: May 2024

Abstract
Background
In recent years, there has been an increase in cases of heart failure, ultimately leading to an increase in hospitalization for heart failure (HF) and cardiovascular mortality. The aim of our study was to evaluate ivabradine combined with beta-blocker versus beta-blocker alone in addition to standard care for chronic heart failure, followed for a period of 6 months for the rate of hospitalization and major adverse cardiovascular event (MACE) in patients with reduced left ventricular ejection fraction (LVEF < 35%).

Results
A total of 64 patients were included in this observational study with 30 patients in the ivabradine + beta-blocker (IVA + BB) group and 34 in the beta-blocker (BB) group. The median (IQR) age of the study sample was 57 (50–62) and 58.5 (55–67) in IVA + BB and BB groups, respectively, with LVEF < 35%. The incidence of the primary endpoint of composite MACE (MI, stroke, death, worsening of HF) was 5 in both groups. The mean heart rate was significantly decreased (p < 0.001) at 3-month and 6-month follow-up from baseline in the ivabradine + beta-blocker group as compared to the beta-blocker group alone, while it significantly increased in the beta-blocker group at 3 months (p < 0.01) and also at sixth months (p < 0.05). Parameters such as the New York Heart Association (NYHA) class and the Minnesota Living with Heart Failure questionnaire (MLWHFQ) were also assessed but did not show significant change.

Conclusion
Overall, observations from the study results show that IVA + BB seems to be overall well tolerated in the study sample, with a somewhat smaller decrease in hospitalization and a delay in MACE events in the sample population enrolled in a tertiary care hospital in India. Further exploration in a larger sample is required concerning the Indian population.
Posterior fossa primary intracranial extraosseous Ewing’s sarcoma: case report
Authors: Shah Shariq Ahmad , Charan Bheru Dan , Agarwal Sushant , Das Sumanta , Singh Pankaj Kumar , Sebastian Leve Joseph Devaranjan , Garg Ajay 
Published: May 2024

Abstract
Background
Primary intracranial Ewing’s sarcoma (ES) is a type of primitive neuroectodermal tumour and is a rare malignant tumour in children and adolescents. The imaging features of ES overlap with other central nervous system embryonal tumours, making it difficult to pinpoint a specific diagnosis. We aim to explore the clinical, neuroimaging and differential diagnoses of this entity.

Case presentation
We describe a 6-month-old infant who presented with complaints of enlarging the head size and poor feeding. Imaging revealed a contrast-enhancing large solid-cystic mass lesion with internal calcification, focal bone erosion and haemorrhage in the posterior fossa. Histopathological examinations, immunohistochemistry, and molecular analysis confirmed ES.

Conclusions
The confirmative diagnosis of primary intracranial ES requires histological examination, immunohistochemical analysis, and genetic detection, along with radiological findings. Surgical excision followed by combined radiotherapy and chemotherapy is the treatment of choice.
The outcome of posterior nasal nerve/vidian nerve neurectomy during FESS on patients of nasal polyposis associated with bronchial asthma
Authors: Elshahaat Hadeer Ahmed , Mobashir Mohamed , Elhawary Abeer , Alnemr Mohamed Abdelmohsen , Sweed Ahmed Hassan , Elmaghawry Mohammed Elsayed 
Published: May 2024

Abstract
Background
Worldwide, bronchial asthma, allergic rhinitis, and chronic rhinosinusitis are highly prevalent conditions, and numerous researches have shown how they affect one another. Still, reports about surgical treatments remain limited.

Aim
To investigate the role of functional endoscopic sinus surgery (FESS) with posterior nasal nerve/vidian neurectomy, as a surgical protocol in the management of chronic rhinosinusitis with nasal polyposis (CRSwNP), and its effect on bronchial asthma (BA) patients’ quality of life and pulmonary function tests.

Methods
This study was a prospective observational study that involved 25 patients with BA and CRSwNP who underwent full-house FESS with bilateral posterior nasal nerve or vidian neurectomy in the Otorhinolaryngology-Head and Neck Surgery Department and were evaluated in the Chest Department, Zagazig University, from May 2022 to December 2023. All included patients were subjected to pre- and post-operative respiratory assessments including spirometry, Asthma Control Questionnaire (ACQ), and Asthma Quality of Life Questionnaire (AQLQ). Also, all patients were subjected to pre- and post-operative nasal assessment including visual analog scale (VAS), nasal endoscopic evaluation, and routine CT paranasal sinus.

Results
This study included 25 patients (11 men and 14 women; age range 18–57 years; mean ± SD of age 33.24 ± 11.3 years). There were statistically significant increases as regards forced vital capacity and forced expiratory volume in 1 s according to preoperative, 3 months, and 6 months postoperative values. As regards ACQ, AQLQ, and VAS scores, there were highly statistically significant improvements according to preoperative, 3 months, and 6 months postoperative follow-up scores. Asthma medication step-down was successful in 52% of patients after 6 months of follow-up.

Conclusions
The quality of life, pulmonary function, and nasal symptoms of people with bronchial asthma combined with CRSwNP can both be alleviated after posterior nasal nerve/vidian neurectomy beside FESS.
Current research progress on the viral immune evasion mechanisms of African swine fever virus
Authors: Weng Changjiang 
Published: May 2024

AbstractAfrican swine fever (ASF), caused by the ASF virus (ASFV), is an acute, severe, and highly contagious infectious disease in domestic pigs and wild boars. Domestic pigs infected with a virulent ASFV strain can have morbidity and mortality rates of up to 100%. The epidemic of ASF has caused serious economic losses to the global pig industry. Currently, there is no safe and effective vaccine or specific drug for treating ASF. Therefore, ASFV still poses a great threat to pig factories. ASFV is a double-stranded DNA virus with a complex icosahedral multilayer structure. The ASFV genome contains 150–170 open reading frames (ORFs) that encode 150–200 proteins. Some ASFV-encoded proteins are involved in virus invasion, genome replication, DNA repair, and virion formation. Some ASFV proteins execute immunomodulatory functions by regulating the host antiviral innate immune response. Accumulating studies have shown that the immunomodulatory functions of ASFV genes are closely related to the virulence and pathogenicity of ASFV isolates. This review summarizes the research advances on ASFV immune evasion mechanisms in African swine fever patients and provides new insights for developing attenuated live vaccine candidates to prevent and control ASF.
Quantitative Analysis of Hemodynamic Changes in Branch Arteries Covered by Flow Diverters
Authors: You Wei , Wei Dachao , Gui Siming , Jiang Jia , Chen Ting , Tang Yudi , Ye Wanxing , Lv Jian , Lin Jun , Chen Peike , Wang Ziyao , Gong Wentao , Jin Hengwei , Ge Huijian , Jiang Yuhua , Sun Yong , Li Youxiang 
Published: May 2024

BACKGROUND AND OBJECTIVES:
Understanding post-treatment hemodynamic alterations and their association with the patency of covered branch arteries is limited. This study aims to identify hemodynamic changes after flow diverter stenting and investigate their correlation with the patency status of covered branch arteries.

METHODS:
All patients treated with pipeline embolization device for anterior cerebral artery aneurysms at our center between 2016 and 2020 were screened for inclusion. Quantitative digital subtraction angiography was used to analyze changes in hemodynamic parameters pre- and post-stenting. The patency status of covered branch arteries after stenting was categorized as either patent or flow impairment (defined as artery stenosis or occlusion).

RESULTS:
A total of 71 patients, encompassing 89 covered branch arteries, were enrolled. Flow impairment was observed in 11.2% (10/89) of the branches. The mean transit time and full width at half maximum (FWHM) in covered branches were significantly prolonged post-stenting (P = .004 and .023, respectively). Flow-impaired branch arteries exhibited hemodynamic shifts contrary to those in patent branch arteries. Specifically, flow-impaired branches showed marked reductions in time to peak, FWHM, and mean transit time (decreases of 32.8%, 32.6%, and 29%, respectively; P = .006, .002, and .002, respectively). Further multivariate analysis revealed that reductions in FWHM in the branches (odds ratio = 0.97, 95% CI: 0.95-0.99, P = .007) and smoking (odds ratio = 14.5, 95% CI: 1.39-151.76, P = .026) were independent predictors of flow impairment of covered branches.

CONCLUSION:
Pipeline embolization device stenting can cause a reduction in blood flow in branch arteries. Compared with patent branches, flow-impaired branches exhibit an increase in blood flow velocity after stenting. Smoking and ΔFWHM in the covered branches indicate flow impairment.