bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flow Cytometric Study of Site‐Directed Chemotherapy with Estradiol‐17β as a Drug Carrier to Human Endometrial Adenocarcinoma Cells in vitro
Authors: Nishiya Iwao , Yoshizumi Noboru , Sato Masayuki , Kagabu Teruo , Fujiwara Jun , Yoshizaki Akira 
Published: August 2010

AbstractThe effects of Estracyt®, HN2 (nitrogen mustard) derivative of estradiol‐17β, and free HN2 on the cell kinetics of the estrogen receptor (ER) positive human endometrial cancer cell line HEC‐1, were investigated using flow cytometry.HN2 at 1 μg/ml showed a marked increase in the S phase and a decrease in the G0 + Gi phase. However, with equivalent doses of Estracyt® at 10 μg/ml, the accumulation in the G2 + M phase was even more marked.Synchronization in the S phase with methotrexate (MTX) showed no increase in sensitivity to these drugs.The above results suggest that the free HN2 has an effect regardless of the cell cycle phase, whereas the effects of Estracyt® may depend on a fixed population of target cells existing in the G0+G1, S and G2 + M phases.Synchronization in the G1 phase with sodium n‐butyrate could increase the target effects of Estracyt® in the S phase.
Obstetric Outcome of Large Foetuses in Malaysian Women
Authors: Chuah C. Y. , Raman Subramaniam 
Published: August 2010

AbstractIn a retrospective review of all deliveries in the University Hospital, Kuala Lumpur in 1984, 192 infants were found to weigh 4,000 g or more giving an incidence of 3.29%. No antenatal complication was found in the majority of cases (80.2%). Postmaturity and diabetes mellitus were present in 13% of cases. Maternal complications included per‐ineal laceration, difficult labour and a higher caesarean rate. The perinatal morbidity was significantly higher in those who delivered big babies. There were however no fetal deaths. Careful vigilance in labour with recourse to caesarean section in those patients expected to have difficult labour is suggested.
Changing Trends of Maternal Mortality in Developing Countries
Authors: Pandit Ramesh D. 
Published: August 2010

AbstractAn indepth study of maternal mortality was carried out by me from 1929 to 1983 at Nowrosjee Wadia Maternity Hospital, Bombay, India. It is revealed that the maternal mortality at N. Wadia Maternity Hospital which was 1,920 per 100,000 live births during 1929–1939 period has come down to 80 per 100,000 live births during 1980–1983 period. The direct obstetric death rate for the period 1929–1939 which was 670 per 100,000 live births has declined to 40 per 100,000 live births for the period 1980–1983, while the indirect obstetric death rate has declined from 690 for period 1929–1939 to 30 for period 1980–1983. Multiple factors were responsible for this. It is emphasised that ideal antenatal, intranatal, and postnatal care is responsible for the decline in the maternal mortality. Confidential maternal mortality committees in various hospitals and institutions, as well as periodic reviews of maternal mortality on a national and international level will help in further reduction of maternal mortality.
Role of Caesarean Section in Low Birth Weight Babies
Authors: Rege Jayant S. , Dastur Nayna A. , Mataliya Manju V. , Pandit Ramesh D. 
Published: August 2010

AbstractThe role of caesarean section in babies weighing less than 2,500 g was studied over a period of 6 months. These caesarean section births were studied with respect to their period of gestation, indications for caesarean section; then their Apgar scores, modes of resuscitation, neonatal complications and the perinatal outcome were compared to that of the babies delivered vaginally in the equivalent weight group. Out of the total 335 caesarean sections in the study period, 91 were done in those, where the baby weight was less than 2,500 g giving an incidence of 27%. Placenta praevia and preeclampsia— eclampsia formed the major maternal indications for section in the baby weight group of 1,000–2,000 g. Among the foetal indications, foetal distress was the commonest. Among the babies weighing less than 2,000 g, 27% of the section babies showed 5 minute Apgar (8–10) as compared to 3.2% of the babies in the vaginal delivery group. Sixty‐eight percent of the caesarean babies were discharged alive in below 2,000 g birth weight group, as compared to 41 % in vaginally delivered group.
Ileus due to Extensive Adhesion Formation after Intraperitoneal Chemotherapy Using Cisplatinum
Authors: Takada Shuichi , Azukizawa Sumio , Kubota Yutaka , Masuda Michihiko 
Published: August 2010

AbstractMany reports in the recent literature deal with intraperitoneal chemotherapy. Though quite effective for ovarian cancer, it is accompanied by side effects. Extensive adhesion formation after intraperitoneal chemotherapy is one of the side effects to which clinicians must pay attention.In this paper, we present a case of ileus due to extensive adhesion formation about 11 months after cessation of intraperitoneal chemotherapy using cisplatinum (CDDP).
Castleman's Disease Associated with Pregnancy: A Case Report
Authors: Yasuda Jinsuke , Sawada Sigenari , Tomioka Megumi , Yamamoto Takao , Okada Hiroji 
Published: August 2010

AbstractA rare case of Castleman's disease is presented. A 26‐year‐old Japanese pregnant woman was found to have an asymptomatic adnexal tumor. Ultrasonography showed a hypoechoic mass with dense central echoes. At laparotomy with presumptive diagnosis of dermoid cyst of the ovary at 15 weeks' gestation, a firm encapsulated retroperi‐toneal mass was resected. Histological examinations identified it as Castleman's disease of the hyaline‐vascular type with focal calcification.Castleman's disease should be included in the differential diagnosis of low abdominal masses.This is the first case of Castleman's disease associated with pregnancy in an Asian.
Combination Chemotherapy for Immature (Malignant) Teratomas of the Ovary
Authors: Singh Pritam , Yordan Edgardo L. , Graham James R. , Wilbanks George D. , Slayton Robert E. , Miller Alexander W. , Ratnam S. S. 
Published: August 2010

AbstractImmature (malignant) teratomas of the ovary without combination chemotherapy are highly fatal neoplasms. Within the last decade postoperative adjuvant combination chemotherapy has been shown to be highly effective and produced long term survival in patients with these tumours. The efficacy of a regimen containing vincristine, acti‐nomycin D and cyclophosphamide is reported with several patients alive free of disease at 5 to 10 years. The factors influencing prognosis, duration of therapy and role of second‐look laparotomy in immature teratomas are discussed.
Pregnancies Established by Intrauterine Insemination with Washed Spermatozoa
Authors: Chiu Tony T. Y. , Tarn Patrick P. L. , Mao Kenneth R. 
Published: August 2010

AbstractIntrauterine insemination with washed and capacitated spermatozoa was performed in 11 couples whose primary cause of infertility was poor semen characteristics, i.e. oligospermia, asthenospermia and teratospermia, and in 9 couples with unexplained cause of infertility. A total of 59 cycles were attempted. Four biochemical pregnancies and 2 viable pregnancies were achieved, resulting in the birth of one boy and one girl.
Status of Transferrin Receptors in Benign and Malignant Lesions of the Cervix
Authors: Buckshee K. , Saha D A. , Agarwal N. , Singh G. 
Published: August 2010

AbstractReactivity for transferrin receptors was studied in 9 cases with benign and 11 cases with malignant lesions of the cervix. Immunostaining reaction for transferrin receptors was positive in 9/11 (81.8%) of the malignant lesions. However, the reactivity was absent (0%) in all of the 9 specimens with benign lesions. The difference in reactivity pattern between benign and malignant lesions was highly remarkable (P< 0.001 Fischer's exact test). Thus the present study denotes that transferrin receptors are associated with active cellular growth (malignant lesions) and virtually absent in the resting tissues (benign lesions).
Peripartum Cardiomyopathy in a Malay Female
Authors: Raman S. , Rachagan S. P. , Marzuki A. 
Published: August 2010

AbstractA case of peripartum cardiomyopathy occurring in a Malay patient is presented. Diagnosis of this condition can be difficult and is usually one of exclusion. The clinical course of the disease is presented highlighting the points in favour of this rather poorly appreciated and misdiagnosed condition. To our knowledge this is the first report of this condition in a Malay patient.
Primary Malignant Fibrous Histiocytoma of the Uterine Body
Authors: Shiromizu Kenji , Ishihara Osamu , Takahashi Michiko , Matsuzawa Masumi , Nishimura Toshinobu , Takayama Shojiro 
Published: August 2010

AbstractAn extremely rare case of primary malignant fibrous histiocytoma of the uterine body was presented. The patient was a 61‐year‐old woman with deep uterine myometrial invasion and had pulmonary multiple metastases 5 months after total abdominal hysterectomy, and despite intensive chemotherapy died 11 months after diagnosis. Light and electron microscopic observations revealed a tumor composed of characteristic fibroblast‐like and histiocyte‐like cells compatible with the malignant fibrous histiocytoma reported previously.
Laparoscopy as a Diagnostic and Therapeutic Technique in Uterine Perforations during First Trimester Abortions
Authors: Pratap Kumar N. , Padma Rao A. 
Published: August 2010

AbstractLaparoscopic analysis of uterine perforation during first trimester medical termination of pregnancy was done in 10 cases out of the 12 perforations in 2,967 MTPs. Incidence of uterine perforation was 3 per 1,000. In 9 out of 10 cases, a laparotomy was avoided due to laparoscopic aid and MTP was completed under laparoscopic vision. Fundus was the commonest site of perforation with no relevance of uterine position. The procedure is safe when performed in indicated cases and an exact diagnosis of the extent of perforation injury can be obtained. This procedure avoids an exploratory laparotomy.
Nuclear Steroid Receptors in Endometrial Cancers
Authors: Fujimoto Jiro , Tamaya Teruhiko , Watanabe Yoshinobu , Arahori Kenji , Sato Shohei , Okada Hiroji 
Published: August 2010

AbstractEstrogen receptor in the cytosol (ERc), in the nuclear KCl extract (ERne), and in the nuclear KCl unextractable fraction (ERnu) of endometrial cancers was detected in all 3 premenopausal cases. In all postmenopausal cases. ERc was detected, but neither ERne nor ERnu were detected in several cases. These results suggest that an ER‐mediated mechanism is present in all endometrial cancers.In 3 premenopausal cases, progestin receptor (PR) and androgen receptor (AR) were detected in the cytosol, and in the nuclear fractions of one well‐ and one moderately‐differentiated tumor. In some postmenopausal cases, PRne was found but not PRc. ARc levels in endometrial cancers were always low in both pre‐ and postmenopausal cases. These findings indicate the presence of some factor by which the pro‐gesterone‐PRc complex translocates to the nucleus of endometrial cancer cells in some postmenopausal cases, and that the nucleus may have progestin‐specific binding sites.
Presence and Expression of Human Papillomavirus Types 16 and 18 DNA Sequences in Cervical Carcinomas
Authors: Hsieh Chang‐Yao , Lee Sheng‐Chung , Huang Su‐Cheng 
Published: August 2010

AbstractDNA of human papillomavirus (HPV) types 16 and 18 has been found closely associated with cervical carcinomas. We have analyzed DNA from a larger number of cervical carcinomas, for the state and expression of the HPV 16 and 18 genome. Among 77 samples, HPV 16 genome was found in 35 (45.5%) while HPV 18 in 14 (18.2%). HPV 18 genome was associated more closely with adenocarcinomas than with squamous cell carcinomas. HPV 16 and 18 genomes were mutually exclusive in terms of their tissue existence. The viral DNA was present in the tissue mainly as integrated forms, although in some tissues there was episomal as well as integrated forms. The sites of HPV DNA integration were random. The copy number of HPV sequences varied greatly among different samples. Poly (A)+ RNA ranging from 1.1 kb to more than 5 kb were detected in HPV 16 or HPV 18 positive tissues using HPV 16 or 18 DNA probe.
Effects of RU 486 on the Mechanical Properties of Rabbit Fallopian Tubes
Authors: Nozaki Masahiro , Nakamura Gen‐ichi 
Published: August 2010

AbstractThe effects of RU 486 on the mechanical activities of the circular smooth muscles of the rabbit oviduct were investigated using an isometric tension recording method. Injection of human chorionic gonadotropin (hCG) markedly increased the frequency of the spontaneous contractions but simultaneous treatment with hCG and RU 486 did not increase the frequency. In the animals treated with hCG, the frequencies and amplitudes of the contraction increased, and the concentrations of progesterone in the sera increased. This action of hCG was suppressed when RU 486 was simultaneously injected. In oviductal smooth muscles simultaneously treated with progesterone and RU 486, the frequency of spontaneous contractions was markedly decreased as in the case of the simultaneous injection of hCG and RU 486. Thus, RU 486 alters the mechanical activities of the fallopian tube by preventing the release of progesterone induced by hCG and by acting against progesterone. This is the first report that RU 486 acts directly on tubal motility.
Combination Chemotherapy for Malignant Mixed Germ Cell Tumours of the Ovary: A Prospective Study
Authors: Singh Pritam , Yordan Edgardo L. , Graham James R , Wilbanks George D. , Slayton Robert E. , Miller Alexander W. 
Published: August 2010

AbstractA prospective study of 10 patients with malignant mixed germ cell tumours of the ovary treated with combination chemotherapy consisting of either vincristine, actinomycin D and cyclophosphamide (VAC) or vinblastine, bleomycin and cisplatin (VBP) is reported. The median age of these patients was 21.5 years and 3 patients had Stage I disease, 4 Stage II and 3 had Stage III disease. A detailed analysis of the pathological and prognostic features of mixed germ cell tumours is presented. Six of these patients are alive and well for periods ranging from 2 to 10 years. Contemporary management of these tumours with chemotherapy including the role of second‐look laparotomy and second‐line chemotherapy is discussed. Optimal therapy of these tumours consists of surgery followed by combination chemotherapy.
Cervical Carcinoma in situ after Incomplete Conisation
Authors: Ueki Minoru , Green G. H. 
Published: August 2010

AbstractTo investigate further the nature and treatment of cervical carcinoma in situ (CIS), 211 conisation specimens reported as showing “incomplete excision of CIS,” obtained at Auckland University's National Women's Hospital were examined and the histological findings correlated with long‐term follow‐up (2 to 16 years); 88.4% were followed for at least 5 years.There was persistence or recurrence in 34.1% of the total. Recurrence was related to the extent of CIS in the cervix, as judged from the incompletely excised sites and remaining tissue blocks. Micro‐invasive carcinoma was found in 4 patients (1.9%) and invasive carcinoma (Stage Ib “occ”) in 2 (0.9%). It was concluded that when the CIS is small in extent in the cervix, or is incompletely excised only at the exocervix, spontaneous disappearance of any remainder can be expected. The findings suggest that the continued existence of incompletely excised CIS is significantly inhibited by the healing process.
Virilizing Pregnancy Luteoma: A Case Report
Authors: Yasuda Jinsuke , Shiroshita Kohhei , Yamamoto Takao , Okada Hiroji 
Published: August 2010

AbstractThe first case report of virilizing pregnancy luteoma in an Asian is presented. Virilizing symptoms such as a deep voice, a male type of escutcheon, coarse facial hair, severe cystic acne and clitomegaly were found in 25‐year‐old Japanese primigravida during the last trimester of pregnancy. Serum androstenedione and testosterone were much higher than in normal pregnancy. The levels of 17‐ketosteroids in urine were also markedly elevated. In this 17‐KS in the urine, large amounts of 11β‐hydroxy‐androsterone (11β‐hydroxylated metabolites of androgen) were found by gaschromatography‐mass spectrometry (GC‐MS).Spontaneous labor started at 38 weeks' gestation, and the patient was delivered of a normal male infant. At 3 weeks postpartum, the elevated androgens returned to normal levels, but the enlarged left ovarian tumor did not regress in size. Pathological diagnosis of the tumor at exploratory laparotomy at 4 weeks postpartum was pregnancy luteoma. Virilizing symptoms regressed slowly after delivery, however the deep voice, male type of escutcheon and clitomegaly remained at 5 years postpartum.
A Vaginal Approach to the Treatment of Genital Prolapse
Authors: Tanaka Shoichi , Yamamoto Hiroshi , Shimano Satoshi , Endoh Toshiaki , Hashimoto Masayoshi 
Published: August 2010

AbstractA series of 84 cases of genital prolapse, operated on at our clinic by way of vaginal hysterectomy with anterior and posterior colporrhaphy during 1976–1985, was clinically analyzed in this study.The cases included 1 nullipara, 1 primipara, 56 cases from para II to V and 26 cases para VI or more.Vaginal hysterectomy with anterior colporrhaphy was performed on 58% of the cases and vaginal hysterectomy with anterior and posterior colporrhaphy was carried out in 41% of the cases. Vaginal hysterectomy with posterior colporrhaphy was performed in only 1% of the cases.Immediate postoperative complications took the form of residual urine in 12 cases of vaginal hysterectomy with anterior colporrhaphy. There was no recurrence in our series after operation.
Pattern of Neonatal Morbidity and Mortality in Infants of Diabetic Mothers
Authors: Faquih Arif M , Mir Nisar A , Kishan J. , Legnain M. 
Published: August 2010

AbstractThe outcome of 145 diabetic pregnancies, seen over a period of 18 months, was analysed. Overall incidence of diabetes in pregnancy was 0.59%, and 70% of the mothers were insulin dependent. Their class distribution was: A‐43 (31%), B‐96 (68%) and C‐6 (4%); 20 (14%) of the mothers had poorly controlled diabetes during the pregnancy. Major maternal complications observed were: toxemia (21), abruptio placentae (7) and polyhydramnios (6). Sixty‐seven (47.8%) mothers delivered at ± 37 weeks of gestation and the cesarean section rate was 39.3%. The mean gestational age and birth weight of infants of diabetic mothers was 37.4 ± 1.7 weeks and 3,898 ± 841 g respectively. The neonatal morbidity observed were: macrosomia (52%), hypoglycemia (46%), asphyxia (38%), polycythemia (36%), hyperbilirubinemia (18%), transient tachypnea of the new born (16%) and hyaline membrane disease (5%). Congenital anomalies were observed in 20 infants. Prematurity, asphyxia, hypoglycemia and birth injuries were more common among infants with macrosomia (p = <0.01).There were 17 perinatal deaths (5 stillbirths and 12 early neonatal deaths) with a perinatal mortality rate of 117.2 compared with 26.7 per 1,000 births in the general population. Adverse prognostic indices for neonatal mortality were: poor metabolic control of diabetes and presence of severe birth asphyxia, prematurity and/or major congenital anomalies.
A Critical Analysis of the Rates and Indications for Caesarean Section in a Developing Country
Authors: Ojo Vincent A. , Okwerekwu Francis O. 
Published: August 2010

AbstractA retrospective analysis of 785 cases of caesarean section was performed, over a 2‐year period. The caesarean section rate was 6.96%—primary section rate being 6.14% andrepeat section rate, 0.82%.The commonest indications for caesarean section were dystocia (2.67%), malpresentation and malposition (1.16%), previous section (0.82%), fetal distress (0.73%) and antepartum haemorrhage (0.63%). A critical discussion on the rates and indications for caesarean section was done. For a reduction in caesarean section rates a re‐appraisal of section for dystocia is essential.
Pattern of Neonatal Mortality in a Government Teaching Institute
Authors: Sangamnerkar M. , Sutaria U. D. , Shrotri A. N. 
Published: August 2010

AbstractThe neonatal mortality during hospital stay of live‐born babies in a large government hospital is assessed in the light of various maternal factors and neonatal problems.The complete records of every neonatal death along with record of all deliveries over a period of 18 months were maintained prospectively and analysed. Out of total 9,374 deliveries, 8,931 were live births, of which 438 were neonatal deaths. Thus the neonatal mortality was 49.04 per 1,000 live births, of which 89.5% were early neonatal deaths. The main contributors to neonatal mortality were prematurity (22.8%), hyaline membrane disease (20.8%), birth asphyxia (15.7%), sepsis (14.4%), malformations (11.4%), other respiratory problems (8.9%) and birth trauma (3.4%). The main causes of late neonatal deaths were sepsis, respiratory problems and malformations. Of the total live births 13.95% were having birth weight of less than 2 kg and these contributed to 79.6% of neonatal deaths. Of all neonatal deaths, 52.5% were preterm babies.The various high risk factors and measures to reduce neonatal mortality are discussed.
FSH, LH, PRL and E2 Levels in Follicular Fluid and Serum of Patients Undergoing Follicle Stimulation with Different Protocols for IVF
Authors: Shin Min‐Tsir , Chu Tang‐Yuan , Hsu Chih‐Hsueh , Yu Mu‐Hsien , Chang Jia‐Shyuhn , Sun David , Lao Zen‐Hwa , Wu Kwo‐Tsang , Lee Chia‐Koon , Yang Chi‐Liu , Hsu Chien‐Tien 
Published: August 2010

AbstractConcentrations of FSH, LH, PRL and E2 in plasma and in follicular fluid were studied by radioimmunoassay in 74 cycles induced for IVF. Three different protocols were used for induction of super‐ovulation: Clomiphene/HCG, clomiphene/HMG/HCG and HMG/HCG.The results showed that the 2 HMG‐treated groups showed significantly higher serum E2 and PRL, and lower LH levels than the clomiphene‐treated group. Similarly, the HMG‐treated protocols also induced more FSH, PRL and E2 in follicular fluid than the clomiphene‐treated protocol, while LH in the follicular fluid in 3 protocols were very close.On the basis of the hormone profiles in serum and follicular fluid noted in this study, we concluded that the HMG‐treated protocol produced a more favorable systemic and local environment for oocyte maturation. PRL levels in serum and follicular fluid, like E2, seemed to be an indicator of oocyte maturation. The LH‐surge inhibition effect of HMG was also confirmed in this study.
Pure Rhabdomyosarcoma of the Corpus Uteri: A Case Report with a Review of the Literature
Authors: Teshima Hideo , Narahara Hisashi , Nishida Junichi , Takada Shinichi , Cheng Schin Zon , Mizutani Katsumi , Mori Hiroyuki , Kigawa Tomonori 
Published: August 2010

AbstractWe report on a 52‐year‐old woman with a pure rhabdomyosarcoma of the corpus uteri. Histopathological study revealed that the tumor was composed only of rhabdomyosarcoma (RMS) and it was not associated with carcinoma or other elements of mixed mesodermal tumor. An undifferentiated tumor element was observed. Using the indirect immunoperoxidase technique for myoglobulin, the filaments with striated muscle was stained in the cytoplasm of the undifferentiated tumor cells, which was regarded as a pure rhabdomyosarcoma of the embryonal type arising from the corpus uteri.
Management of Pregnancy Complicated by Diabetes Mellitus: Experience at the University Hospital, Kuala Lumpur
Authors: Dutta R. , Kulenthran A. , Sivanesaratnam V. , Chan S. P. , Zaini A. , Sinnathuray T. A. 
Published: August 2010

AbstractA retrospective study of 97 patients with pregnancy complicated by Diabetes Mellitus was carried out. An in‐patient management regime was undertaken with combined care by the obstetrician and endocrinologist. Common antenatal complications encountered were urinary tract infections and pre‐eclampsia. A policy of routine induction of labour at 38 weeks gestation was adopted unless delivery was mandated earlier. The caesarean section rate was 41%. There were 2 perinatal deaths, both due to lethal congenital defects.