bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free essential amino acid feeding improves endurance during resistance training via DRP1‐dependent mitochondrial remodelling
Authors: Jang Jiwoong , Kim Yeongmin , Song Taejeong , Park Sanghee , Kim Hee‐Joo , Koh Jin‐ho , Cho Yoonil , Park Shi‐Young , Sadayappan Sakthivel , Kwak Hyo‐Bum , Wolfe Robert R. , Kim Il‐Young , Choi Cheol Soo 
Published: June 2024

AbstractBackgroundLoss of muscle strength and endurance with aging or in various conditions negatively affects quality of life. Resistance exercise training (RET) is the most powerful means to improve muscle mass and strength, but it does not generally lead to improvements in endurance capacity. Free essential amino acids (EAAs) act as precursors and stimuli for synthesis of both mitochondrial and myofibrillar proteins that could potentially confer endurance and strength gains. Thus, we hypothesized that daily consumption of a dietary supplement of nine free EAAs with RET improves endurance in addition to the strength gains by RET.MethodsMale C57BL6J mice (9 weeks old) were assigned to control (CON), EAA, RET (ladder climbing, 3 times a week), or combined treatment of EAA and RET (EAA + RET) groups. Physical functions focusing on strength or endurance were assessed before and after the interventions. Several analyses were performed to gain better insight into the mechanisms by which muscle function was improved. We determined cumulative rates of myofibrillar and mitochondrial protein synthesis using 2H2O labelling and mass spectrometry; assessed ex vivo contractile properties and in vitro mitochondrial function, evaluated neuromuscular junction (NMJ) stability, and assessed implicated molecular singling pathways. Furthermore, whole‐body and muscle insulin sensitivity along with glucose metabolism, were evaluated using a hyperinsulinaemic–euglycaemic clamp.ResultsEAA + RET increased muscle mass (10%, P < 0.05) and strength (6%, P < 0.05) more than RET alone, due to an enhanced rate of integrated muscle protein synthesis (19%, P < 0.05) with concomitant activation of Akt1/mTORC1 signalling. Muscle quality (muscle strength normalized to mass) was improved by RET (i.e., RET and EAA + RET) compared with sedentary groups (10%, P < 0.05), which was associated with increased AchR cluster size and MuSK activation (P < 0.05). EAA + RET also increased endurance capacity more than RET alone (26%, P < 0.05) by increasing both mitochondrial protein synthesis (53%, P < 0.05) and DRP1 activation (P < 0.05). Maximal respiratory capacity increased (P < 0.05) through activation of the mTORC1‐DRP1 signalling axis. These favourable effects were accompanied by an improvement in basal glucose metabolism (i.e., blood glucose concentrations and endogenous glucose production vs. CON, P < 0.05).ConclusionsCombined treatment with balanced free EAAs and RET may effectively promote endurance capacity as well as muscle strength through increased muscle protein synthesis, improved NMJ stability, and enhanced mitochondrial dynamics via mTORC1‐DRP1 axis activation, ultimately leading to improved basal glucose metabolism.
Can perception of fractured endodontic files benefit 1st degree dental students and dental educators: A questionnaire‐based survey
Authors: Maqbool Manahil , Asogan Valar Maty , Akram Zunaira , Then Bernard , Noorani Tahir Yusuf 
Published: June 2024

AbstractPurposeThis study aimed (i) to assess the perception of dental undergraduate (1st degree dental students) learners about endodontic file separation (EFS) and knowledge of its avoidance, as well as (ii) to aid dental educators in conceptualizing and designing student‐directed courses for better understanding. The rationale of this study was to provide both learners and educators with a tool to help self‐assess/impart knowledge and devise simple yet innovative modern ways of teaching in the field of endodontics. The study utilized a self‐reporting dataset from one institution to disclose this limitation.MaterialsA validated self‐administered questionnaire from a previous study was converted into an online Google form link consisting of 15 multiple‐choice questions. This was distributed to 100 Year 4 and Year 5 1st degree dental students. Pearson chi‐square test was used for statistical analysis (p < 0.05).ResultsThe response rate was 81%. The majority of the learners expressed that performing endodontic treatment in permanent (100%) posterior teeth of old‐aged people causes EFS (95.1%). Ninety‐nine percent answered that EFS was a gender‐independent factor, 72.8% perceived that patient anxiety leads to EFS, and 88.9% said that the apical third was more prone to instrument fracture and had the poorest prognosis (95.1%). Hundred percent, 93.8%, 100%, 92.6%, 100%, and 97.5% of respondents, respectively, perceived that the role of operator, coronal flare, ethylenediaminetetraacetic acid (EDTA) gel, cleaning endodontic instrument, reusing instrument, and choice of instrument affects the occurrence of EFS. A total of 71.6% said hand files fractured, while 86.4% perceived that stainless steel alloy files separated easily, and 69.1% of learners perceived that EFS occurred often during the cleaning and shaping stage.ConclusionsThe perception of 1st degree dental students regarding EFS and knowledge of its avoidance was good. Results from this study confirmed that the 1st degree dental students’ clinical training courses and study modules adopted and designed by their dental educators were well‐suited and appropriate.
HOVON 104, long‐term follow‐up of bortezomib‐dexamethasone induction therapy followed by autologous stem cell transplantation in newly diagnosed AL amyloidosis patients
Authors: Minnema Monique C. , Nasserinejad Kazem , Hegenbart Ute , Ypma Paula F. , Wu Ka Lung , Kersten Marie Jose , Croockewit Sandra , Zweegman Sonja , Tick Lidwine , Broijl Annemiek , Koene Harry , Bos Gerard M. J. , Sonneveld Pieter , Schönland Stefan O. 
Published: June 2024

AbstractThe HOVON 104 studied bortezomib‐dexamethasone induction therapy and autologous stem cell transplantation in 50 patients, of whom 35 received an autologous stem cell transplantation (ASCT). We demonstrate a 5‐year overall survival (OS) of 73% and progression‐free survival (PFS) of 52% for all 50 patients with a median follow‐up of 61.3 months. For the 35 transplanted patients, calculated from the date of ASCT, the 5‐year OS and PFS were 91% and 68%, respectively. After ASCT, the rate of organ response improved over time but stabilized around 3 years. A complete cardiac response was seen in around 60% of patients and remained stable from 2 years onward. Reaching complete renal response was slower over time and achieved by 61% of the renal‐affected patients at 5 years. We confirm the excellent outcomes after ASCT and demonstrate a 60% complete organ response with longer follow‐up.
Similarities and differences of bone marrow and peripheral blood samples from acute myeloid leukemia patients in terms of cellular heterogeneity and ex‐vivo drug sensitivity
Authors: Caliskan Gulser , Pawitan Yudi , Vu Trung Nghia 
Published: June 2024

AbstractBackgroundBone marrow (BM) evaluation is the de facto standard for diagnosis, molecular analysis, risk stratification, and therapy response assessment in acute myeloid leukemia (AML), but in patients with a high number of circulating blast cells, the peripheral blood (PB) sample could provide similar information as BM. However, there is no large‐scale molecular study comparing the two specimens in terms of their gene expression profiles, cellular heterogeneities, and ex‐vivo drug sensitivity.MethodologyWe used (i) the BEAT‐AML cohort each with detailed molecular data; (ii) cell‐type deconvolution to estimate leukemic and immune cell proportions between specimen types; (iii) differential expression (DE) and drug‐cell type association analysis; and (iv) logistic regression models to assess the association between induction therapy response, cell‐type composition and first‐line drug treatment.ResultsResults: We identified 207 patients having BM and 116 patients having PB samples. There was a total of 1271 DE genes (false discovery rate < 0.05) between BM and PB; the top enriched pathways in terms of DE genes belong to the immune system pathways. Aggregated ex‐vivo drug response profiles from the two specimens were largely similar, as were the cellular components, except for the GMP‐like cell type (17% in BM vs. 5% in PB, p‐value = 2 × 10−7). Among the specimen‐specific results, the GMP‐like subtype was associated with multiple drug resistance in BM and the ProMono‐like subtype in PB. Several cell types were associated with the response to induction therapy, but the impact of specimen type on the interaction of cell type and cytarabine‐associated induction therapy was not statistically significant for most cell types.ResultsConclusions: Even though there are molecular and cellular differences between BM and PB samples, they show many similarities in ex‐vivo drug response profiles, indicating the clinical utility of the substantially less‐invasive PB samples.
Synthesis of novel pyrido[3,4‐d]pyrimidine‐thiazolidione‐1,2,4‐oxadiazoles as potent EGFR targeting anticancer agents
Authors: Varaprasadu Botla Durga , Haridasyam Sharath Babu , Koppula Shiva Kumar 
Published: June 2024

AbstractIn this study, we designed and synthesized a number of novel pyrido[3,4‐d]pyrimidine‐thiazolidine‐1,2,4‐oxadiazole derivatives and investigated them in vitro for their inhibitory action toward epidermal growth factor receptor (EGFR) kinases and antiproliferative activity against two different cell lines, MCF‐7 and A‐549. When compared to the lead chemicals, 5‐fluorouracil and erlotinib, some of the compounds demonstrated acceptable activity. Among them, the most promising compounds 4d and 4e displayed potent anticancer activity against both MCF‐7 and A‐549 cell lines (IC50 values remaining: 1.97 ± 0.28 μM to 8.14 ± 0.52 μM, respectively); the comparative IC50 values for 5‐fluorouracil and erlotinib in these cell lines were 5.56 ± 0.34 μM, 12.66 ± 0.76 μM, and 3.64 ± 0.49 μM, 9.54 ± 0.75 μM, respectively; as well as excellent kinase inhibitory activities (EGFR: IC50 = 0.34 ± 0.07 μM and 0.42 ± 0.06 μM) were more effective than the conventional drug Erlotinib (IC50 = 0.42 ± 0.02 μM).
Effect of alveolar ridge preservation at periodontally compromised molar extraction sockets: A retrospective cohort study
Authors: Dai Anna , Li Hao‐Yu , Kang Sen , Lin Renjie , Huang Jia‐Ping , Mao Feifei , Ding Pei‐Hui 
Published: June 2024

AbstractBackgroundTo date, the clinical evidence regarding the effectiveness of alveolar ridge preservation (ARP) in restricting alveolar bone height and width change after extraction at periodontally compromised molar extraction sockets still remains controversial. This retrospective cohort study aims to evaluate the effect of ARP in molars extracted for periodontal reasons.MethodsRetrospective data were collected from patient electronic records from January 2019 to December 2023. Patients with Stage III/IV periodontitis who underwent extraction of molars for periodontal reasons were screened for eligibility. The outcomes included the horizontal and vertical dimensions of alveolar bone. The need for additional augmentation procedure during implantation was also evaluated. A linear regression model was used to adjust for known confounders.ResultsA total of 80 sockets were included in this study, of which 27 sockets received ARP therapy after extraction while 53 sockets experienced natural healing (NH). ARP resulted in significantly less bone height change in the periodontally compromised molar sites compared to the NH group (p < 0.001). In sockets displaying a height disparity of >2 mm between the buccal and palatal/lingual walls, the ARP group exhibited advantageous outcomes in terms of ridge width change, surpassing the NH group (p = 0.004). Moreover, the percentage for additional augmentation was significantly reduced in the ARP compared to the NH group (p = 0.006). Age, sex, smoking, jaw, location, and buccal wall thickness did not show any significant effect on bone height change.ConclusionARP had benefits on limiting ridge resorption subsequent to molar extraction for periodontal reasons.
Lake Wellington and West Walker River in Great Basin of western United States: History and genesis
Authors: Wesnousky STEVEN G. , Sion Brad 
Published: June 2024

ABSTRACTClosed basins within the Great Basin of the western United States were home to numerous lakes during the Pleistocene. One of these paleolakes along the western edge of the Great Basin, Lake Wellington, once filled a 10 × 25‐km expanse of Smith Valley to depths approaching 90 m. This and other lakes that existed during the Pleistocene are generally considered to be pluvial, indicating contemporaneity with either or all a period of cooler climate, increased rainfall and snowmelt, and relatively reduced rates of evaporation as compared to today. Here we combine the results of 36Cl terrestrial cosmogenic nuclide surface exposure dating with soils and geomorphic observations to suggest Lake Wellington was not a pluvial lake but instead the result of a large landslide prior to ~43 ± 15 ka along the West Walker River where it exited Smith Valley. The observations collected also reveal an ancestral course of the West Walker River ~85 m above the current river grade. Attributing the elevation difference to incision caused by active 0.05 ± 0.01 mm a−1 uplift of the underlying Singatse and assuming the ancestral course followed the same path as today places the age of the paleoriver course at ~1.7 Ma.
Confocal Raman spectroscopic study of melt inclusions from peridotite xenoliths in economic and barren kimberlites from Kaapvaal Craton
Authors: Khan Sahroz , Fedortchouk Yana , Feichter Monika , Toth Tivadar M. 
Published: June 2024

AbstractMelt inclusions trapped in minerals inside xenoliths from kimberlites can help to examine the composition of kimberlite melt and/or metasomatic processes in the subcratonic lithospheric mantle as well as shed more light on the role of these melts in diamond destruction. In this study, confocal Raman spectroscopy of secondary melt inclusions in olivine from xenoliths in five different Kaapvaal Craton kimberlites was used for testing any compositional differences between melt inclusions from economically productive (Bultfontein and Frank Smit) and uneconomic diamond barren (Matsoku, Thaba Putsoa, and Pipe 200) kimberlite pipes. The xenoliths represent a range of pressures (37–45 kbar) and temperatures (1000–1300°C). The 26 daughter minerals identified within melt inclusions include Ca–Mg (±Na, K, P, Cl)‐bearing carbonates, alkali (±Ca, Ba, Cl, F, H2O, CO2)‐bearing sulfates, phosphates, oxides, silicates, and a rare nitrate. The mineral assemblages in melt inclusions are similar in both economic and barren kimberlite pipes from the interior and the edge of the craton, indicating the similar composition of the entrapped melts in all studied samples. However, the petrographic study revealed different metasomatic processes recorded by xenoliths from barren and economic kimberlites. Metasomatism by a melt enriched in K, Ca, and H2O could be instrumental in diamond destruction and the low diamond grade of the three barren kimberlites from Lesotho. Our study revealed no effect of kimberlite melt composition on diamond preservation in the studied kimberlites: instead, diamond grade is most likely affected by diamond destruction in the mantle source prior to kimberlite emplacement with kimberlite ascent.
Custom total knee arthroplasty with personalised alignment showed better 2‐year functional outcome compared to off‐the‐shelf arthroplasty
Authors: Vogel Nicole , Kaelin Raphael , Arnold Markus P. 
Published: June 2024

AbstractPurposeCustomised individually made (CIM) total knee arthroplasty (TKA) with personalised alignment is relatively new and evidence is limited. The aim of this study was to compare patient‐reported outcome measures between CIM and off‐the‐shelf (OTS) TKA patients in a matched‐pair analysis with a 2‐year follow‐up.MethodsIn this single‐centre, prospective cohort study, propensity score matching was performed on 51 CIM and 51 OTS TKA. Data were measured at baseline, at 4 months, 1 and 2 years and included the Forgotten Joint Score (FJS‐12), the High Activity Arthroplasty Score (HAAS), the Knee injury and Osteoarthritis Outcome Score (KOOS), the EQ‐5D‐3L, the EQ‐Visual Analogue Scale, satisfaction, overall knee improvement, willingness to undergo the surgery again and the Knee Society Score.ResultsAt 2 years follow‐up, the FJS‐12 (77 vs. 67, p = .058), HAAS (13 vs. 11, p < .001), KOOS daily living (92 vs. 86, p = .029), KOOS sport (76 vs. 65, p = .019), KOOS quality of life (81 vs. 71, p = .028) and the EQ‐5D (.95 vs. .90, p = .030) were higher for CIM TKA compared to OTS TKA. Satisfaction rate was 92% for CIM TKA and 84% for OTS TKA (p = .357). Most patients reported an improvement in the overall knee state (94% CIM and 90% OTS, p = .487) and almost all patients would undergo the surgery again (96% CIM and 98% OTS, p = .999).ConclusionThe current study found that CIM TKA patients had better functional outcomes at 2 years. Patient satisfaction was high and not statistically significantly different from OTS TKA patients.Level of EvidenceLevel II, prospective cohort study.
A comparative video analysis of hamstring injuries mechanism and situational pattern in men's and women's football (soccer)
Authors: Della Villa Francesco , Buckthorpe Matthew , Pellegrini Alessandro , Ranzini Alice , Esposito Fabio , Crescenzo Christian , Nanni Gianni , Zago Matteo 
Published: June 2024

AbstractPurposeTo describe the injury mechanism and situational patterns of severe (absence >28 days) hamstring muscle injuries in professional male and female football (soccer) players.MethodsThe data for males were sourced from Serie A clubs participating in both national and international competitions from 2018 to 2021. For the female cohort, hamstring injuries were identified during matches of the top national/international competitions from 2017 to 2023. Video footage was obtained, and three raters categorised injury mechanisms and situational patterns. Injuries were also examined according to the month, minute and location.ResultsA total of 129 severe hamstring injuries were identified, with 64 occurring in females and 65 in males. Video analysis was possible for 29 (45%) female cases and 61 (94%) male cases. Female injuries had longer lay‐off times (97.8 ± 77.1 days) than males (39.6 ± 20.9 days). Females had a higher proportion of indirect contact injuries (34%) than males (13%) and a lower proportion of non‐contact injuries (66% vs. 87%). Four situational patterns were identified: running was the most common for both sexes, representing 59% of female injuries and 41% of male injuries. Over‐stretching injuries were split across open and CKC scenarios but collectively explained nearly half (48%) of male injuries but only one in five (21%) female injuries. Kicking injuries had a higher proportion in females (17%) than males (10%). Injuries were more common in the second half for females and the first half for males.ConclusionFemales had a higher proportion of indirect contact, running and kicking injuries and a lower proportion of non‐contact and stretch‐type injuries than males. Understanding injury patterns can inform tailored prevention programs, considering sex‐specific differences.Level of EvidenceLevel IV.
Frequency‐Division Multiplexing Continuous Variable Quantum Dense Coding with Broadband Entanglement
Authors: Liang Shaocong , Cheng Jialin , Qin Jiliang , Li Jiatong , Shi Yi , Zeng Baiyun , Yan Zhihui , Jia Xiaojun , Xie Changde , Peng Kunchi 
Published: June 2024

AbstractQuantum dense coding (QDC) provides great potential for high‐capacity quantum communication. However, it is highly demanded for practical applications to realize high‐capacity QDC with multiple coded information. Here, a high‐capacity QDC with multiple streams is reported in different channels simultaneously through frequency‐division multiplexing (FDM). The broadband entangled state is generated from a pair of degenerate optic al parametric amplifiers with short cavity lengths. Based on the resultant broadband entanglement, multiple pieces of information coded using binary phase shift keying (BPSK) are transferred with the FDM method. As an experimental demonstration, four pieces of information composed of pseudo‐random numbers are transmitted at a rate of 4 Mbit s–1 using BPSK encoding. The decoded bit error rate reaches , which is an average 35‐fold improvement compared with the classical scheme. Furthermore, it is possible to make full use of sideband resource for four different information by using orthogonal FDM. This scheme can be extended to more different information by directly increasing the FDM sideband subchannels, and opens an avenue to construct high‐capacity quantum communication, while minimizing the cost of quantum resource.
Symmetry Molecular Design Strategy for Highly Efficient Blue Electroluminescence with Hot Exciton Mechanisms
Authors: Fang Kaibo , Zhang Jiasen , Li Wei , Mu Xilin , Liu Chunyu , Wu Yujie , Feng Tingting , Qiao Xianfeng , Wang Tao , Ge Ziyi 
Published: June 2024

AbstractEmitters with a hot exciton mechanism are regarded as one of the most promising candidates for organic light‐emitting diodes (OLEDs). In this study, a deep‐blue emitter with the hot exciton mechanism is reported, namely 2An‐PCz, by integrating a pair of carbazole groups with a 9,9′‐bi‐anthracene nucleus. Owing to the symmetric molecular architecture and intrinsic local excited state character, multiple high‐lying reverse intersystem cross (hRISC) channels and large overlaps of frontier molecular orbits (FMOs) can be formed, facilitating rapid hRISC processes as well as enhancement of radiative transition rates simultaneously. Combined with the strong luminescence properties brought by the unique X‐packing mode, a high photoluminescence quantum yield of 60.5% is achieved in the non‐doped state. Strikingly, non‐doped deep‐blue OLEDs exhibited a maximum external quantum efficiency (EQE) of 10.50% with minimal efficient roll‐off, which is one of the highest values for deep‐blue organic light‐emitting devices based on hot exciton emitters thus far. The magneto‐electroluminescence (MEL) experiment and transient electroluminescence measurements corroborated that both the high EQE and suppressed efficiency roll‐off are attributable to the rapid “hot exciton” channels.