bluuebunny/crossref_metadata_2025_split huggingface dataset:
CAMTA1 T polymorphism is associated with neuropsychological test performance in older adults with cardiovascular disease
Authors: MILLER Lindsay A. , GUNSTAD John , SPITZNAGEL Mary Beth , MCCAFFERY Jeanne , MCGEARY John , POPPAS Athena , PAUL Robert H. , SWEET Lawrence H. , COHEN Ronald A. 
Published: June 2011

AbstractBackground:  Cardiovascular disease has long been associated with poor neurocognitive outcome, with multiple pathophysiological mechanisms that are linked to cognitive impairment in older adults. Although less frequently examined, insulin dysregulation is known to affect vascular function and the associated brain dysfunction in cardiovascular disease. Accordingly, genetic factors tied to insulin regulation may make certain people with cardiovascular disease more susceptible to cognitive dysfunction. Specifically, the calmodulin‐binding transcription activator 1 (CAMTA1) genotype, which has been examined as a risk factor for Type 2 diabetes and has been linked to reduced episodic memory performance in healthy young adults, is a potential candidate gene.Methods:  Blood samples were obtained from 113 older adults with cardiovascular disease who also underwent neuropsychological testing. Carriers of either one or two copies of the T allele of CAMTA1 were categorized into one group (n= 63), whereas non‐carriers were categorized into a second group (n= 50).Results:  Analyses showed that carriers of the T allele performed more poorly on tests of attention, executive function, and psychomotor speed, but not on tests of memory. Carriers of the T allele also performed more poorly on a measure of global cognitive function.Conclusions:  Results indicate that CAMTA1 genotype is associated with cognitive function in older adults with cardiovascular disease, because carriers of the T allele performed more poorly on tests of attention, executive function, and psychomotor speed. Contrary to expectations, there were no differences in memory performance among carriers and non‐carriers of the T allele. Given these mixed findings, further studies are necessary to elucidate the association between CAMTA1 and cognition, particularly gene expression and neuroimaging studies.
Depression–dementia medius: Between depression and the manifestation of dementia symptoms
Authors: KOBAYASHI Toshiyuki , KATO Satoshi 
Published: June 2011

AbstractDepression and dementia, among the most common conditions in clinical practice, sometimes coexist, sometimes succeed each other, and often confuse clinicians. In the present paper, the clinical concept of ‘depression–dementia medius’ (which includes pseudodementia and depression in Alzheimer's disease as exemplars) is proposed, in reference to Janet's concept of psychological tension. Because psychosomatically complex human lives are always in a state of dynamic equilibrium, it seems sensible to propose that pseudodementia and depression in Alzheimer's disease are located within a spectrum extending from depression without dementia symptoms to dementia without depression. From the Janetian viewpoint, pseudodementia is regarded as uncovered latent dementia as a result of reduced psychological tension. Dementia is more than a fixed progressive condition under this view, and is a manifestation of dynamic mental activities. Characterizing these entities through perspectives such as psychological tension may yield deep insights in clinical practice.
Headache Disorders in the Millennium Cohort: Epidemiology and Relations With Combat Deployment
Authors: Jankosky Christopher J. , Hooper Tomoko I. , Granado Nisara S. , Scher Ann , Gackstetter Gary D. , Boyko Edward J. , Smith Tyler C. ,   for the Millennium Cohort Study Team
Published: June 2011

(Headache 2011;51:1098‐1111)Objective.— Characterize migraine and other headache disorders within a large population‐based US military cohort, with an emphasis on the temporal association between military deployment and exposure to combat.Background.— Little research has been published on the prevalence of headache disorders in the US military population, especially in relation to overseas deployments and exposure to combat. A higher than expected prevalence of migraine has previously been reported among deployed US soldiers in Iraq, suggesting an association. Headache disorders, including migraine, could have important effects on the performance of service members.Methods.— A total of 77,047 US active‐duty, Reserve, and National Guard members completed a baseline questionnaire between July 2001 to June 2003 for the Millennium Cohort Study. Headache disorders were assessed using the following survey‐based measures: self‐reported history of provider‐diagnosed migraine, recurrent severe headache within the past year, and recent headaches/bothered a lot within the past 4 weeks. Follow‐up surveys were completed on average 3 years after baseline (mean = 2.7 years; range = 11.4 months to 4.5 years).Results.— The overall male and female prevalence of self‐reported headache conditions at baseline were: provider‐diagnosed migraine, 6.9% and 20.9%, respectively; recurrent severe headache, 9.4% and 22.3%, respectively; and bothered a lot by headaches, 3.4% and 10.4%, respectively. Combat deployers had significantly higher odds of any new‐onset headache disorders than non‐deployers (adjusted odds ratios = 1.72 for men, 1.84 for women; 95% confidence intervals, 1.55‐1.90 for men, 1.55‐2.18 for women), while deployers without combat exposure did not.Conclusions.— Deployed personnel with reported combat exposure appear to represent a higher risk group for new‐onset headache disorders. The identification of populations at higher risk of development of headache provides support for targeted interventions.
Use of Antimigraine Treatments by General Practitioners
Authors: Ducros Anne , Romatet Sophie , Saint Marc Thierry , Allaf Bashar 
Published: June 2011

(Headache 2011;51:1122‐1131)Objectives.— To assess headache treatment patterns in 2 groups: general practitioners (GPs) who suffered from migraine themselves (GP‐M) and GPs having a close family member with migraine (GP‐CFM). The secondary objective was to assess the impact of migraine on activities of daily living in these 2 groups.Background.— Personal experience of migraine may influence prescribing practices of physicians treating patients with migraine. Little data are available on perceptions of migraine by GPs.Methods.— This was an observational, cross‐sectional, pharmacoepidemiological survey conducted in primary care in France. Most GPs completed 1 of 2 questionnaires, and GPs belonging to both groups could complete both. Data were collected on headache treatments used (GP‐M) or prescribed (GP‐CFM), and on self‐reported (GP‐M) or described (GP‐CFM) migraine features and impact on daily activities.Results.— The most frequently reported acute headache treatments in both groups were triptans and non‐steroidal anti‐inflammatory drugs (>75% of GPs); >81% of GPs in both groups were satisfied with acute headache treatments. Only 6.9% of the GP‐M group used and 17.2% of the GP‐CFM group prescribed a prophylactic treatment, which was considered satisfactory by 46.2% and 56.1%, respectively. In the preceding 3 months, 79.4% of the GP‐M group reported handicap in daily activities due to migraine, 23.6% interruption of extraprofessional activities and 7.6% interruption of work. In the GP‐CFM group, 32.6% described interruption of extraprofessional activities and 57.3% interference with daily activities or work.Conclusions.— Acute headache treatment prescribed by French GPs for their own migraines or those of their relatives respect practice guidelines and is considered as effective and satisfactory. Use of prophylactic medication is low and its effectiveness perceived as limited. Better use of prophylactic treatments may attenuate the impact of migraine on daily activities.
Chronic Kidney Disease: A Risk Factor for Dementia Onset: A Population‐Based Study. The Osaki‐Tajiri Project
Authors: Sasaki Yumi , Marioni Ricardo , Kasai Mari , Ishii Hiroshi , Yamaguchi Satoshi , Meguro Kenichi 
Published: June 2011

OBJECTIVES: To examine the relationship between the incidence of dementia and chronic kidney disease (CKD).DESIGN: Longitudinal data analyses.SETTING: Baseline data and follow‐up data from the Osaki‐Tajiri Project.PARTICIPANTS: The Tajiri Project dementia prevalence study in 1998 involved 497 community‐dwelling, older men and women (346 with Clinical Dementia Rating score (CDR) of 0 (healthy), 119 with a CDR of 0.5 (questionable dementia), and 32 with a CDR of 1 or greater (dementia)). Two hundred fifty‐four participants with CDR of 0 and 0.5 who were reclassified as converters (n=28) or nonconverters (n=230) to dementia in the incidence study in 2003 were followed.MEASUREMENTS: The prevalence of CKD and the onset of dementia were retrospectively analyzed, and the effects of other vascular risk factors on converters and CKD were analyzed.RESULTS: Weighted logistic regression showed CKD to be significantly associated with incident dementia after adjustment for age, sex, education, hypertension, diabetes mellitus, dyslipidemia, ischemic heart disease, and anemia. The odds ratio for conversion to dementia for those with CKD compared to those without was 5.3 (95% confidence interval=1.7, 16.2). Apart from dyslipidemia, there were no associations between dementia and the other vascular risk factors.CONCLUSION: CKD was strongly associated with the incidence of dementia independent of age, sex, education, and other vascular risk factors.
Cholinesterase Inhibitor and Memantine Use in Newly Admitted Nursing Home Residents with Dementia
Authors: Parsons Carole , Briesacher Becky A. , Givens Jane L. , Chen Yong , Tjia Jennifer 
Published: June 2011

OBJECTIVES: To quantify the use of cholinesterase inhibitors (ChEIs) and memantine in nursing home (NH) residents with dementia upon NH admission and 3 months later and to examine factors associated with reduction in therapy.DESIGN: Retrospective cohort study.SETTING: Nationwide sample of U.S. NHs.PARTICIPANTS: Three thousand five hundred six NH residents with dementia newly admitted in 2006.MEASUREMENTS: Data from pharmacy dispensing records were used to determine ChEI and memantine medication use upon NH admission and at 3‐month follow‐up. The Minimum Data Set was used to determine resident‐ and facility‐level characteristics. Severity of dementia was defined using the Cognitive Performance Scale (CPS).RESULTS: Overall, 40.1% (n=1,407) of newly admitted NH residents with dementia received ChEIs and memantine on NH admission. Use of ChEIs and memantine on admission was significantly greater in residents with mild to moderately severe dementia (41.2%) than in those with advanced dementia (33.3%, P=.001). After 3 months, ChEI and memantine use decreased by about half in both groups (48.6% with mild to moderately severe dementia vs 57.0% with advanced dementia, P<.05). NH residents with advanced dementia were significantly more likely reduce their use of ChEIs and memantine than those with mild to moderately severe dementia (odds ratio=1.44, 95% confidence interval=1.03–2.01, P=.04).CONCLUSION: Many NH residents with advanced dementia receive ChEIs and memantine upon NH admission, and approximately half of these decrease their medication use over the ensuing months. Further study is required to optimize use of ChEIs and memantine in NH populations and to determine the effects of withdrawing therapy on resident outcomes.
Placental trophoblasts shifted Th1/Th2 balance toward Th2 and inhibited Th17 immunity at fetomaternal interface
Authors: LIU FENGJUAN , GUO JING , TIAN TING , WANG HANZHI , DONG FANYI , HUANG HEFENG , DONG MINYUE 
Published: June 2011

Liu F, Guo J, Tian T, Wang H, Dong F, Huang H, Dong M. Placental trophoblasts shifted Th1/Th2 balance toward Th2 and inhibited Th17 immunity at fetomaternal interface. APMIS 2011.The aims were to clarify the effect of placental trophoblasts on T lymphocytes by assessing production of cytokines and expression of transcription factors regulating Th1, Th2, and Th17 immunity in T lymphocytes. Placental trophoblasts were isolated and conditioned medium was made after trophoblast cultivation for 72 h. T lymphocytes were cultured in presence or absence of conditioned medium. ELISA was used to detect concentration of IL‐2, TNF‐α, IFN‐γ, IL‐4, IL‐10, and IL‐17 in supernatants of T cell and real‐time PCR was used to detect the status of Th1 (T‐bet, STAT‐4), Th2 (GATA‐3, STAT‐6), and Th17 (RORC) immunity in T lymphocyte. We found that the level of IL‐2, IFN‐γ, TNF‐α, and IL‐17 was significantly decreased when T lymphocytes were cultured in conditioned medium compared with control, while IL‐10 and IL‐4 level were not significantly changed. The presence of conditioned medium significantly decreased the ratio of Th1/Th2. The expression of GATA‐3 and STAT‐6 were significantly increased and STAT‐4 was reduced when T lymphocyte was cultured in conditioned medium, while the expression of T‐bet and RORC was not significantly different. We concluded that placental trophoblast‐induced shift of Th1/Th2 balance toward Th2 and inhibition of Th17 might be among the mechanisms involved in maternal tolerance to fetus.
Periodontal dressing may influence the clinical outcome of non‐surgical periodontal treatment: a split‐mouth study
Authors: Genovesi AM , Ricci M , Marchisio O , Covani U 
Published: June 2011

To cite this article:   Int J Dent Hygiene10, 2012; 284–289  DOI: 10.1111/j.1601‐5037.2010.00493.xGenovesi AM, Ricci M, Marchisio O, Covani U.Periodontal dressing may influence the clinical outcome of non surgical periodontal treatment: a split‐mouth study.Abstract:  Introduction: After scaling and root planning (SRP), healing induces the formation of a junctional long epithelium rather than a new connective attachment. We hypothesize that the placement of a periodontal dressing will be able to prevent detachment of coagulum inducing proper healing and improving periodontal parameters. Materials and methods: This split‐mouth study included 30 patients with periodontitis with ages ranging from 35 to 70 years. Probing pocket depth (PD), probing attachment level (PAL), bleeding on probing index (BoP) and plaque index (PI) were assessed before and after therapy. The group of patients received SRP in a span of 24 h. Then, a periodontal dressing was applied on the test side and it was removed after 1  week. Results: Control group: The difference between PD values at baseline and after therapy was 1.6 ± 0.6 mm. The difference in PAL (ΔPAL) measurement was 1.4 ± 0.4. Test group: there was a greater PD reduction, this being 2.4 ± 0.6 mm on average. The difference in PAL was 2.5 ± 0.4 mm. Conclusions: Our results clearly suggest that the use of a periodontal dressing improves the periodontal parameters after an SRP procedure. This is probably due to clot stabilization and prevention of bacterial colonization during wound healing.
Effect of field pea (Pisum sativum L.) level on intake, digestion, ruminal fermentation and in vitro gas production in sheep fed maintenance diets
Authors: BASTIDA GARCIA Jorge L. , GONZÁLEZ‐RONQUILLO Manuel , DOMÍNGUEZ VARA Ignacio A. , ROMERO‐BERNAL José , CASTELÁN ORTEGA Octavio 
Published: June 2011

ABSTRACTThe objective of this study was the characterization of the nutritive value, ruminal fermentation and nutrient digestibility of field pea (Pisum sativum L.) hay (FPH) by‐product through in situ, in vitro and in vivo tests. A FPH diet was administered ad libitum to four sheep (live weight (LW) 38.0 ± 2.0 kg) at four inclusion levels (0, 25, 50 and 75%) over a conventional sorghum grain/oat straw ration in a 4 × 4 Latin square design. The in situ degradability of FPH was 67% dry matter (DM), 71% crude protein and 66% neutral detergent fiber (NDF). The inclusion of FPH did not affect (P ≥ 0.05) the DM (61 ± 0.4 g/LW0.75/day) and organic matter (OM) intake (56 ± 0.7 g/LW0.75/day). Total DM digestibility (68 ± 2.5%), OM (70 ± 3%), and NDF (60 ± 3%), were not different (P ≥ 0.05) between control and FPH inclusion diets. The diet had no effect on ruminal pH, ruminal ammonia concentration, total and individual volatile fatty acids. The chemical composition and sheep intake behavior indicate that FPH by‐product is medium quality forage when incorporated in maintenance rations.
Analysis of genetic diversity and phylogenetic relationship of red deer subspecies in XinJiang, China
Authors: JIA Bin , LI Ren‐Yan , ZHAO Zong‐Sheng , YAN Gen‐Qiang , XI Ji‐Feng , BLAIR Hugh T. , LI Da‐Quan , ZHANG Jian‐Xin , ZHAO Xi‐Tang 
Published: June 2011

ABSTRACTPolymorphisms for seven microsatellite loci in three red deer subspecies (9 populations) found in XinJiang were detected by polymerase chain reaction (PCR), 12% nondenaturation polyacrylamide gel electrophoresis and the Sanguinetti silver staining method. Numbers of alleles, average effective numbers of alleles (E) and the average rate of homozygosity, allelic frequencies of seven microsatellite loci, polymorphism information content (PIC), mean heterozygosity (H) and genetic distances among the populations were calculated for each population. Dendrograms were constructed based on genetic distances by the neighbor‐joining method (NJ), utilizing molecular evolutionary genetics analysis software PHYLIP (3.6). The phylogenetic tree was constructed based on allelic frequencies using maximum likelihood (ML); the bootstrap value was estimated by bootstrap test in the tree. Lastly, phylogenesis was analyzed. The results showed that four of the seven microsatellite loci were highly polymorphic, but BMS2508 and Celjp0023 showed no polymorphism and BM5004 was a neutral polymorphism. It is our conclusion that the four microsatellite loci are effective DNA markers for the analysis of genetic diversity and phylogenetic relationships among the three red deer subspecies. The mean PIC, H and E‐values across the microsatellite loci were 0.5393, 0.5736 and 2.64, which showed that these microsatellite loci are effective DNA markers for the genetic analysis of red deer. C.e. songaricus populations from Regiment 104, 151 and Hami are clustered together. C.e. yarkandensis populations from Regiment 35, Xaya and Alaer are clustered together. These two clusters also cluster together. Lastly, C.e. sibiricus populations from Burqin, Regiment 188 and the first two clusters were clustered together. The phylogenetic relationship among different red deer populations is consistent with the known origin, history of breeding and geographic distributions of populations.
Measurement of carbonic anhydrase isozyme VI (CA‐VI) in swine sera, colostrums, saliva, bile, seminal plasma and tissues
Authors: NISHITA Toshiho , ITOH Seigo , ARAI Sachiko , ICHIHARA Nobutune , ARISHIMA Kazuyoshi 
Published: June 2011

ABSTRACTSwine secretory carbonic anhydrase VI (CA‐VI) was purified from swine saliva and an antibody to CA‐VI was generated. A specific and sensitive enzyme‐linked immunosorbent assay (ELISA) has been developed for the measurement of swine CA‐VI. The assay can detect as little as 5 ng/mL of swine CA‐VI. Typical standard curves were determined for a range of CA‐VI solutions (7.8 to 500 ng/mL). The coefficients of variation for these solutions were less than 5%. When 500, 250 or 100 ng/mL of swine CA‐VI was added to swine sera, the recoveries were 102.0%, 109.7% and 100.2%, respectively. The concentrations of CA‐VI in the saliva (26.2 ± 30.4 µg/mL), sera (3.3 ± 4.9 ng/mL), bile (153.0 ± 114.0 ng/mL), seminal plasma (124.0 ± 39.0 ng/mL) and parotid gland (441.3 ± 90.0 µg/g wet tissue), submaxillary gland (88.1 ± 124.4 µg/g wet tissue), sublingual gland (58.6 ± 24.6 µg/g wet tissue) and gallbladder (2.4 ± 1.3 µg/1g wet tissue) were determined by ELISA. The concentration of CA‐VI in colostrum was 163.3 ± 101.4 ng/mL and did not decrease within 10 days following parturition. An immunohistochemical reaction to anti‐CA‐VI antiserum was observed in the columnar epithelial cells lining the gallbladder. These data suggest that secretory CA‐VI plays various roles in pH regulation and the maintenance of ion and fluid balance.
Meeting the Needs of Parents in Early Childhood Intervention: The Educational Partnership With Parents—Good Practice and Challenges
Authors: Pretis Manfred 
Published: June 2011

AbstractThere is broad conceptual consensus that the effectiveness and efficiency of early childhood intervention (ECI) for vulnerable children is correlated with the active involvement and full participation of parents. This requires a general understanding of each family's needs and desires and specific strategies for determining what each family needs to achieve the outcomes they desire. However, the effect sizes of parent programs or involvement—due to methodological issues and mediator variables—still vary significantly between the programs. The author highlights the importance of shared understanding and shared decision between professionals and parents as a main predictor of high outcome in ECI.
Promoting Health‐Related Fitness for Elementary Students With Intellectual Disabilities Through a Specifically Designed Activity Program
Authors: Davis Kathryn , Zhang Guili , Hodson Patricia 
Published: June 2011

AbstractThe Motivate, Adapt, and Play Program was specifically designed as an adapted physical activity (PA) program for students with intellectual disabilities (ID) to meet required school PA policies to combat childhood obesity. The policies commonly require a minimum of 30 min of PA per school day. A study was undertaken to test the efficacy of the program. Twenty‐five students with ID (9 girls, 16 boys; ages 9.7 ± 1.2) from four elementary schools in the southeastern United States participated in the study. The health‐related fitness measures of the 16‐m shuttle run test, the modified curl‐up test, and the back‐saver sit‐and‐reach test were completed at the beginning and at the end of an 8‐week period. Body mass index (BMI) measurements were also obtained. During the interval, participants completed a 30 min/day, 5 days/week activity program, focusing on cardiovascular endurance, flexibility, and muscular strength and endurance activities, utilizing specialized equipment. Over the 8 weeks, there was a significant increase in the health‐related fitness scores obtained. As expected, there was a slight decrease in BMI over 8 weeks, although it was a nonsignificant finding. The findings suggest that the health‐related fitness of students with ID can be improved through engaging in a school‐based daily adapted PA program.