bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of sickle cell disease and its treatment on ovarian reserve in reproductive‐aged Black women
Authors: Shandley Lisa M. , Fasano Ross M. , Spencer Jessica B. , Mertens Ann C. , McPherson Laura J. , Dixon Meredith A. , Poliektov Natalie , Butler Hailly E. , James Sonjile M. , Howards Penelope P. 
Published: June 2024

SummaryWe compared serum anti‐Mullerian hormone (AMH) levels in women with sickle cell disease (SCD) (n = 152) to those of Black comparison women (n = 128) between the ages of 20 and 45 years and evaluated the impact of hydroxyurea (HU) and iron overload on ovarian reserve in those with SCD. SCD treatment was abstracted from medical records. Linear regression models were fit to examine the relationship between log(AMH) and SCD, adjusting for age. The analysis was repeated to account for HU use (current, previous, never) and iron overload (ferritin ≥1000 ng/mL vs. <1000 ng/mL). AMH estimates among women with SCD were lower than those among comparison women (2.23, 95% confidence interval [CI] 1.80–2.76 vs. 4.12, 95% CI 3.11–5.45, respectively). Women with SCD who were currently using HU had 63% lower (95% CI 43–76) AMH values than comparison women; those with SCD with prior or no HU use also had lower AMH estimates than comparison women, but the difference was less pronounced. There were no differences in predicted AMH values among women with SCD for those with and without iron overload. Women with SCD and low AMH may have a shorter reproductive window and may benefit from referral to a reproductive specialist.
Matched case–control comparison of surgical success after XEN45 Gel Stent and PRESERFLO MicroShunt implantation in a Caucasian population
Authors: Lüke Jan Niklas , Dietlein Thomas S. , Widder Randolf A. , Roessler Gernot F. , Lüke Vincent , Enders Philip , Lappa Alexandra , Kiessling David 
Published: June 2024

AbstractBackgroundThe aim of this study was to compare the outcome of implantation of a XEN45 Gel Stent with the outcome of implantation of a Preserflo MicroShunt in a matched‐pair analysis in eyes being naïve to filtering surgery.MethodsIn this comparative, retrospective study, 50 eyes that had undergone XEN45 Gel Stent implantation were compared with 50 eyes after Preserflo implantation. Follow‐up was at least 6 months, and surgical success was measured by criteria A (IOP < 21 mmHg, IOP reduction >20%, no repeat surgery); criteria B (IOP < 18 mmHg, IOP reduction >20%, no repeat surgery); and criteria C (IOP ≤15 mmHg, IOP reduction ≥40%, no repeat surgery).ResultsAfter a follow‐up period of 12 months, mean IOP had decreased from preoperative 25.2 ± 4.8 mmHg in the XEN group to 14.5 ± 4.0 (n = 35) and from 25.3 ± 6.8 mmHg to 11.9 ± 2.9 (n = 41) in the Preserflo group, respectively. The IOP at the last follow‐up of the two groups differed significantly (p < 0.01). The probability of surgical success did not differ concerning Criteria A and B, but surgical success was significantly higher in the Preserflo group for Criteria C (60%, p < 0.01).ConclusionBoth the Preserflo and XEN45 Gel Stent provide an effective and safe treatment option for advanced glaucoma and have a high potential to reduce intraocular pressure. Absolute IOP levels of <16 mmHg after 12 months were significantly more frequent in the Preserflo group.
DynTrix: A Hybrid Representation for Dynamic Graphs
Authors: Vago B. , Archambault D. , Arleo A. 
Published: June 2024

AbstractHybrid graph representations combine two or more network visualization techniques in a unique drawing, simultaneously leveraging their strong traits. Since their introduction in the early 2000s, hybrid representations have gained significant research interest, with the introduction of new techniques and comparative user studies. However, all this research has not considered dynamic graphs. In this paper, we investigate hybrid graph representations in a dynamic network context and present DynTrix. Our system uses the NodeTrix representation as a basis, but the research extends this representation to the dynamic network domain. DynTrix supports automatic or manually created clusters/matrices across time. Drawing stability is implemented through aggregation and users can rearrange the nodes/matrix positions and pin them. DynTrix visualizes the temporal dynamics of the network through a combination of movement and element highlighting. We also introduce the concept of volatility, that allows the identification of actors in the network that are the most volatile. Matrices can be ordered such that stable cores gravitate towards the centre of the matrix. We integrate this technique in a visual analytics application for the exploration of offline dynamic networks and evaluate our system through case studies and qualitative expert interviews. Experts agree on the capabilities of the system, noting its potential for the analysis of dynamic networks through hybrid representations.
The coloniality of power in Uganda's Nakivale Refugee Settlement: struggling for humanitarian authority amidst the 2018 corruption scandal
Authors: Tegenbos Jolien 
Published: June 2024

AbstractThis paper addresses the complexity of studying the coloniality of humanitarianism and present‐day relationships of power and authority in refugee settings. Building on 13 months of fieldwork, it presents an ethnographic account of the 2018 refugee corruption scandal in Uganda and the Nakivale Refugee Settlement. The core of this paper's argument is based on a grounded analysis of how ‘the saga’ not only exposed corruptive practices in the country's refugee programme, but also the meanings of being ‘human’ and what this implies for making claims to humanitarian authority. The paper asserts that the way in which the scandal unravelled in the (inter)national media, and how it affected sociopolitical tensions in the camp, revealed a deeply fraught conception of both human and humanitarian duality, embedded in a coloniality of power. Ultimately, power imbalances, frictions, and conflicts between national, international, and refugee actors highlighted a deep‐rooted and historical struggle for humanity and legitimate humanitarian authority.
Outcomes of apexification in immature traumatised necrotic teeth and risk factors for premature tooth loss: A 20‐year longitudinal study
Authors: Wikström Alina , Brundin Malin , Mohmud Afrah , Anderson Maria , Tsilingaridis Georgios 
Published: June 2024

AbstractBackground/AimTo evaluate the long‐term survival of immature traumatized incisors with pulp necrosis and apical periodontitis after endodontic treatment with two apexification techniques (calcium hydroxide apexification and MTA‐apical plug) and to identify major factors affecting the survival of these teeth.Materials and MethodsRecords of 2400 children and adolescents were screened for presence of traumatic dental injuries to immature incisors where endodontic treatment with the two apexification techniques was performed during January 2003 and December 2022, compared to a control group of mature teeth treated with conventional endodontic techniques. The studied variables were age; sex; apexification technique, presence of luxation and hard tissue injuries; preoperative root development stage (RDS), preoperative and postoperative periapical index (PAI), the time‐point for tooth loss, and overall survival time in years. Kaplan–Meier estimates were used to graphically present the survival functions and Cox proportional hazard model to calculate hazard ratios (HR, 95% CI).ResultsThe median survival time was 10 years for calcium hydroxide apexification, 16.1 for MTA‐apexification, for luxation injuries other than intrusions and avulsions 15.5 years, for intrusions 12.5 years and for avulsions 6.8 years. The variables with significant negative impact on tooth survival were calcium hydroxide apexification, avulsion and postoperative PAI 3–5. No significant relationships were found for the variables MTA apexification, concussion; subluxation; lateral luxation; extrusion, intrusion, hard tissue injuries, preoperative RDS and PAI scores and postoperative PAI 1–2. After adjustment, the risk for premature tooth loss was 13.5 times higher in calcium hydroxide apexification, approximately 2 to 4 times higher in PAI 3–5, and 5.6 times higher in avulsions.ConclusionsCalcium hydroxide apexification, avulsion, and postoperative PAI 3–5 were identified as prognostic variables with significant negative impact on the risk for premature tooth loss.
Nuclear receptors for epidermal lipid barrier: Advances in mechanisms and applications
Authors: Yin Xidie , Yan Yu , Li Jiandan , Cao Zhi , Shen Shuzhan , Chang Qihang , Zhao Yiting , Wang Xiuli , Wang Peiru 
Published: June 2024

AbstractThe skin plays an essential role in preventing the entry of external environmental threats and the loss of internal substances, depending on the epidermal permeability barrier. Nuclear receptors (NRs), present in various tissues and organs including full‐thickness skin, have been demonstrated to exert significant effects on the epidermal lipid barrier. Formation of the lipid lamellar membrane and the normal proliferation and differentiation of keratinocytes (KCs) are crucial for the development of the epidermal permeability barrier and is regulated by specific NRs such as PPAR, LXR, VDR, RAR/RXR, AHR, PXR and FXR. These receptors play a key role in regulating KC differentiation and the entire process of epidermal lipid synthesis, processing and secretion. Lipids derived from sebaceous glands are influenced by NRs as well and participate in regulation of the epidermal lipid barrier. Furthermore, intricate interplay exists between these receptors. Disturbance of barrier function leads to a range of diseases, including psoriasis, atopic dermatitis and acne. Targeting these NRs with agonists or antagonists modulate pathways involved in lipid synthesis and cell differentiation, suggesting potential therapeutic approaches for dermatosis associated with barrier damage. This review focuses on the regulatory role of NRs in the maintenance and processing of the epidermal lipid barrier through their effects on skin lipid synthesis and KC differentiation, providing novel insights for drug targets to facilitate precision medicine strategies.
STAT3‐induced lncRNA GNAS‐AS1 accelerates keloid formation by mediating the miR‐196a‐5p/CXCL12/STAT3 axis in a feedback loop
Authors: Liu Yun , Ma Teng‐Xiao , Fan Peng‐Fei , Wang Ze , Wang Zhe , Li Lei 
Published: June 2024

AbstractKeloids are pathological scar tissue resulting from skin trauma or spontaneous formation, often accompanied by itching and pain. Although GNAS antisense RNA 1 (GNAS‐AS1) shows abnormal upregulation in keloids, the underlying molecular mechanism is unclear. The levels of genes and proteins in clinical tissues from patients with keloids and human keloid fibroblasts (HKFs) were measured using quantitative reverse transcription PCR, western blot and enzyme‐linked immunosorbent assay. The features of HKFs, including proliferation and migration, were evaluated using cell counting kit 8 and a wound healing assay. The colocalization of GNAS‐AS1 and miR‐196a‐5p in HKFs was measured using fluorescence in situ hybridization. The relationships among GNAS‐AS1, miR‐196a‐5p and C‐X‐C motif chemokine ligand 12 (CXCL12) in samples from patients with keloids were analysed by Pearson correlation analysis. Gene interactions were validated by chromatin immunoprecipitation and luciferase reporter assays. GNAS‐AS1 and CXCL12 expression were upregulated and miR‐196a‐5p expression was downregulated in clinical tissues from patients with keloids. GNAS‐AS1 knockdown inhibited proliferation, migration, and extracellular matrix (ECM) accumulation of HKFs, all of which were reversed by miR‐196a‐5p downregulation. Signal transducer and activator of transcription 3 (STAT3) induced GNAS‐AS1 transcription through GNAS‐AS1 promoter interaction, and niclosamide, a STAT3 inhibitor, decreased GNAS‐AS1 expression. GNAS‐AS1 positively regulated CXCL12 by sponging miR‐196‐5p. Furthermore, CXCL12 knockdown restrained STAT3 phosphorylation in HKFs. Our findings revealed a feedback loop of STAT3/GNAS‐AS1/miR‐196a‐5p/CXCL12/STAT3 that promoted HKF proliferation, migration and ECM accumulation and affected keloid progression.
Clinical characteristics of women with HIV in the RESPOND cohort: A descriptive analysis and comparison to men
Authors: Hutchinson J. , Neesgard B. , Kowalska J. , Grabmeier‐Pfistershammer K. , Johnson M. , Kusejko K. , De Wit S. , Wit F. , Mussini C. , Castagna A. , Stecher M. , Pradier C. , Domingo P. , Carlander C. , Wasmuth J. , Chkhartishvili N. , Uzdaviniene V. , Haberl A. , d'Arminio Monforte A. , Garges H. , Gallant J. , Said M. , Schmied B. , van der Valk M. , Konopnicki D. , Jaschinski N. , Mocroft A. , Greenberg L. , Burns F. , Ryom L. , Petoumenos K. 
Published: June 2024

AbstractBackgroundWomen with HIV are globally underrepresented in clinical research. Existing studies often focus on reproductive outcomes, seldom focus on older women, and are often underpowered to assess sex/gender differences. We describe CD4, HIV viral load (VL), clinical characteristics, comorbidity burden, and use of antiretroviral therapy (ART) among women with HIV in the RESPOND study and compare them with those of the men in RESPOND.MethodsRESPOND is a prospective, multi‐cohort collaboration including over 34 000 people with HIV from across Europe and Australia. Demographic and clinical characteristics, including CD4/VL, comorbidity burden, and ART are presented at baseline, defined as the latter of 1 January 2012 or enrolment into the local cohort, stratified by age and sex/gender. We further stratify men by reported mode of HIV acquisition, men who have sex with men (MSM) and non‐MSM.ResultsWomen account for 26.0% (n = 9019) of the cohort, with a median age of 42.2 years (interquartile range [IQR] 34.7–49.1). The majority (59.3%) of women were white, followed by 30.3% Black. Most women (75.8%) had acquired HIV heterosexually and 15.9% via injecting drug use. Nearly half (44.8%) were receiving a boosted protease inhibitor, 31.4% a non‐nucleoside reverse transcriptase inhibitor, and 7.8% an integrase strand transfer inhibitor. The baseline year was 2012 for 73.2% of women and >2019 for 4.2%. Median CD4 was 523 (IQR 350–722) cells/μl, and 73.6% of women had a VL <200 copies/mL. Among the ART‐naïve population, women were more likely than MSM but less likely than non‐MSM (p < 0.001) to have CD4 <200 cells/μL and less likely than both MSM and non‐MSM (p < 0.001) to have VL ≥100 000 copies/mL. Women were also more likely to be free of comorbidity than were both MSM and non‐MSM (p < 0.0001).ConclusionRESPOND women are diverse in age, ethnicity/race, CD4/VL, and comorbidity burden, with important differences relative to men. This work highlights the importance of stratification by sex/gender for future research that may help improve screening and management guidelines specifically for women with HIV.
Effect of nonpharmacological interventions on nutrition status, complications and quality of life in head and neck cancer patients undergoing radiotherapy: A systematic review and meta‐analysis
Authors: Jin Xiaolei , Fan Yuying , Guo Conghui , Yang Jianrong , Zeng Ying‐chun , Zhang Jun‐e 
Published: June 2024

AbstractPurposeTo evaluate the effect of nonpharmacological therapies on nutrition status, complications and quality of life in head and neck cancer patients and to provide a basis for clinical practice.MethodsThis systematic review was reported in accordance with the Preferred Reporting Items for Systematic Review and Meta‐analysis statement. Ten databases were systematically searched for all available articles from construction to November 2023. Two researchers independently conducted literature screening, data extraction and quality evaluation. Cochrane Review Manager 5.3 was used for meta‐analysis.ResultsFinally, 27 RCT studies including 2814 patients with head and neck cancer were included. Five categories of interventions were used: nutritional support, exercise, swallowing function training, psychological intervention and low‐level laser therapy. Nonpharmacological interventions can improve body weight loss in patients with HNC at the end of treatment (MD: 1.66 kg; 95% CI: 0.80 to 2.51), and subgroup analysis showed that nutritional support, psychological intervention and low‐level laser therapy were effective. Nonpharmacological interventions can also ameliorate decreases in BMI (MD: 0.71; 95% CI: 0.16 to 1.26) and reduce the incidence of malnutrition (RR: 0.76; 95% CI: 0.67 to 0.86), oral mucositis (RR: 0.54; 95% CI: 0.37 to 0.80) and gastrointestinal complications (RR: 0.61; 95% CI: 0.38 to 0.96) during radiotherapy; however, no significant differences were found in other complications and quality of life.ConclusionNonpharmacological interventions can improve the nutrition status of patients with head and neck cancer and reduce the incidence of severe oral mucositis and gastrointestinal complications during radiotherapy but have no significant impact on quality of life.
Resilient urban turnaround in migration governance studies
Authors: Zapata‐Barrero Ricard 
Published: June 2024

AbstractToday, cities are under multiple pressures because they must provide responses to global migration challenges, but have limited governance capacity. This is placing chronic stress on physical infrastructures, basic resources, and urban planning, which most often cities must face alone. There is a rising awareness that doing nothing may increase instability and social conflict, giving rise to more segregation, and racism. Focusing on the crucial tension between what cities might do (sovereignty) and what they can do (constraints), this article seeks first to incorporate ‘urban resilience thinking’ into the current ‘local turn’ literature on migration governance. In order to achieve this theoretical advancement, a fourth‐pronged approach is followed. First, the article proposes that ‘urban resilience’ captures the emerging but dispersed patterns of pro‐active cities, and urges for an analysis of the development of migration governance capacities. Second, a transformative approach to urban migration governance resilience is proposed, and its conceptual consequences explored. Subsequently, the article's focus is on demonstrating the distinctive characteristics of urban resilience when applied to migration governance research, with a particular emphasis on the potential novel contributions that may arise. Finally, in light of the novelties of this research area, the main empirical environments of urban resilience are specified. The concluding remarks close the argumentation by returning to the place of urban resilience thinking within the local turn literature, while also pointing to its normative and methodological potentialities.
Factors associated with COVID‐19 vaccine uptake and hesitancy among multinational refugees and migrants in Jordan
Authors: Ali Manal , Salam Mahmoud 
Published: June 2024

AbstractThis article explores the factors associated with COVID‐19 vaccine uptake and hesitancy among multinational refugees and migrants residing in various regions of Jordan. Drawing on an analysis of data collected from 636 participants in December 2021, only 58.2 per cent of the refugee community in Jordan received COVID‐19 vaccines, knowing that vaccine hesitancy compromises vaccination campaign efforts to control the spread of the disease. In fact, the International Organization for Migration (IOM) and local Jordanian authorities are well aware that, unless sufficiently vaccinated, the clustered populations of refugees and migrants might witness future infectious outbreaks similar to COVID‐19. This study reveals that COVID‐19 vaccine hesitancy is evident among the refugee and migrant populations, who are mainly sceptical of its efficiency and safety. Migrants and refugees also have a preference for certain types of COVID‐19 vaccines. In light of the findings, future interventions are needed to mitigate their concerns and boost vaccine confidence. A more holistic policy approach should prioritize migrants and refugees who are female, unemployed, less educated, and/or have poor knowledge about COVID‐19 and its vaccines. Unfortunately, imposing the COVID‐19 vaccination as a compulsory measure has been poorly received by some migrants and refugees, making them more hesitant.
Aggregate uncertainty, information acquisition, and analyst stock recommendations
Authors: Singh Amanjot , Singh Harminder , Welagedara Venura 
Published: June 2024

AbstractWe examine the informativeness of analyst stock recommendations in the presence of aggregate uncertainty. Our results suggest that a one standard deviation increase in aggregate uncertainty decreases the likelihood of influential recommendation revisions by 5.26%. Increased aggregate uncertainty leads to a small stock price impact for upgrade and downgrade recommendations. Our findings reveal consistent search for information by investors, which, support a post‐recommendation price drift amidst high aggregate uncertainty. We further find that investors of firms with fewer distracted shareholders, less readable financial statements, and more informed trading seek more information when aggregate uncertainty is high. Our study highlights that investors become more cautious while responding to analysts' stock recommendations during high aggregate uncertainty.
Integrative bioinformatics approach yields a novel gene expression risk model for prognosis and progression prediction in prostate cancer
Authors: Zhang Yunyan , Liu Zhuolin , Yu Liu , Fan Aoyu , Li Yunpeng , Li Xiaobo , Chen Wei 
Published: June 2024

AbstractProstate cancer (PCa), a prevalent malignancy among elderly males, exhibits a notable rate of advancement, even when subjected to conventional androgen deprivation therapy or chemotherapy. An effective progression prediction model would prove invaluable in identifying patients with a higher progression risk. Using bioinformatics strategies, we integrated diverse data sets of PCa to construct a novel risk model predicated on gene expression and progression‐free survival (PFS). The accuracy of the model was assessed through validation using an independent data set. Eight genes were discerned as independent prognostic factors and included in the prediction model. Patients assigned to the high‐risk cohort demonstrated a diminished PFS, and the areas under the curve of our model in the validation set for 1‐year, 3‐year, and 5‐year PFS were 0.9325, 0.9041 and 0.9070, respectively. Additionally, through the application of single‐cell RNA sequencing to two castration‐related prostate cancer (CRPC) samples and two hormone‐related prostate cancer (HSPC) samples, we discovered that luminal cells within CRPC exhibited an elevated risk score. Subsequent molecular biology experiments corroborated our findings, illustrating heightened SYK expression levels within tumour tissues and its contribution to cancer cell migration. We found that the knockdown of SYK could inhibit migration in PCa cells. Our progression‐related risk model demonstrated the potential prognostic value of SYK and indicated its potential as a target for future diagnosis and treatment strategies in PCa management.