bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of Variable Turbine Efficiency in Run‐Of‐River Hydropower Design Under Deep Uncertainty
Authors: Yildiz Veysel , Brown Solomon , Rougé Charles 
Published: June 2024

AbstractWhen less water is available, hydropower turbines are less efficient, or have to stop altogether. This reality is often neglected in recent work on the planning and operations of hydropower systems, despite widespread expected increases in drought intensity, frequency and duration. This paper is the first to integrate variable‐efficiency turbines into a hydropower plant design framework that accounts for design optimization as well as deep uncertainty in climatic and socio‐economic variables. Specifically, this framework focuses on leveraging multi‐objective robust decision making for the financially robust design of run‐of‐river hydropower plants, whose output is highly sensitive to flow variability. Application to five plants in Türkiye challenges two key design assumptions, use of net present value as a design objective and use of identical turbines. Instead, maximizing the benefit‐cost ratio yields plants with better financial viability over a range of plausible futures. They tend to have smaller capacity, and feature a small turbine that is well‐adapted to low‐flow periods. Another key insight is that socio‐economic uncertainties have as much or even more impact on robustness than climate conditions. In fact, these uncertainties have the potential to make many small hydropower projects too risky to build. Our findings are of considerable practical relevance at a time where 140 GW of unexploited small hydropower potential could help power the energy transition. They also highlight the need for similar research in reservoir‐based plants, considering over 3,000 such plants planned or in construction worldwide.
Interactions of Logjams, Channel Dynamics, and Geomorphic Heterogeneity Within a River Corridor
Authors: Marshall Anna , Wohl Ellen , Iskin Emily , Zeller Lucas 
Published: June 2024

AbstractNatural rivers are inherently dynamic. Spatial and temporal variations in water, sediment, and wood fluxes both cause and respond to an increase in geomorphic heterogeneity within the river corridor. We analyze 16 two‐km river corridor segments of the Swan River in Montana, USA to examine relationships between logjams (distribution density, count, and persistence), channel dynamism (total sinuosity and average channel migration), and geomorphic heterogeneity (patch density) in the river corridor. We hypothesize that (a) more dynamic river segments correlate with a greater presence, persistence, and distribution of logjams; (b) higher annual peak discharges correspond with greater channel dynamism and logjam presence and distribution; and (c) greater logjam distribution densities and channel dynamism are predictive of more spatially heterogeneous sections of the river corridor. Our results suggest that, first, decadal‐scale channel dynamism, as reflected in total sinuosity, corresponds to greater numbers of logjams and greater persistence of logjams through time. Second, higher peak discharges correspond to greater presence and distribution of logjams, but not to greater channel dynamism. Third, greater geomorphic heterogeneity in the river corridor, as reflected in the spatial distribution of landscape patch density, is explained by greater logjam distribution density, total sinuosity, and proportions of beaver meadows. Our results reflect the complex interactions of water, sediment, and wood in river corridors; the difficulties of interpreting causal relationships among these variables through time; and the importance of spatial and temporal analyses of past and present river processes to understand future river conditions.
MAGPRIME: An Open‐Source Library for Benchmarking and Developing Interference Removal Algorithms for Spaceborne Magnetometers
Authors: Hoffmann Alex Paul , Moldwin Mark B. , Imajo Shun , Finley Matthew G. , Sheinker Arie 
Published: June 2024

AbstractMagnetometers are essential instruments in space physics, but their measurements are often contaminated by various external interference sources. In this work, we present a comprehensive review of existing magnetometer interference removal methods and introduce MAGPRIME (MAGnetic signal PRocessing, Interference Mitigation, and Enhancement), an open‐source Python library featuring a collection of state‐of‐the‐art interference removal algorithms. MAGPRIME streamlines the process of interference removal in magnetic field data by providing researchers with an integrated, easy‐to‐use platform. We detail the design, structure, and functionality of the library, as well as its potential to facilitate future research by enabling rapid testing and customization of interference removal methods. Using the MAGPRIME Library, we present two Monte Carlo benchmark results to compare the efficacy of interference removal algorithms in different magnetometer configurations. In Benchmark A, the Underdetermined Blind Source Separation (UBSS) and traditional gradiometry algorithms surpass the uncleaned boom‐mounted magnetometers, achieving improved correlation and reducing median error in each simulation. Benchmark B tests the efficacy of the suite of MAGPRIME algorithms in a boomless magnetometer configuration. In this configuration, the UBSS algorithm proves to significantly reduce median error, along with improvements in median correlation and signal to noise ratio. This study highlights MAGPRIME's potential in enhancing magnetic field measurement accuracy in various spacecraft designs, from traditional gradiometry setups to compact, cost‐effective alternatives like bus‐mounted CubeSat magnetometers, thus establishing it as a valuable tool for researchers and engineers in space exploration and magnetism studies.
Magmatic Storage and Volatile Fluxes of the 2021 La Palma Eruption
Authors: Dayton K. , Gazel E. , Wieser P. E. , Troll V. R. , Carracedo J. C. , Aulinas M. , Perez‐Torrado F. J. 
Published: June 2024

AbstractThe 2021 La Palma eruption (Tajogaite) was unprecedented in magnitude, duration, and degree of monitoring compared to historical volcanism on La Palma. Here, we provide data on melt inclusions in samples from the beginning and end of the eruption to compare the utility of both melt and fluid inclusions as recorders of magma storage. We also investigated compositional heterogeneities within the magmatic plumbing system. We found two populations of olivine crystals: a low Mg# (78–82) population present at the beginning and end of eruption, recording the maximum volatile contents (2.5 wt % H2O, 1,800 ppm F, 700 ppm Cl, 3,800 ppm S) and a higher Mg# (83–86) population sampled toward the end of the eruption, with lower volatile contents. Despite their host composition, melt inclusions share the same maximum range of CO2 concentrations (1.2–1.4 wt %), indicating olivine growth and inclusion capture at similar depths. Overall, both melt and fluid inclusions record similar pressures (450–850 MPa, ∼15–30 km), and when hosted in the same olivine crystal pressures are indistinguishable within error. At these mantle pressures, CO2 is expected to be an exsolved phase explaining the similar range of CO2 between the two samples, but other volatile species (F, Cl, S) behave incompatibly, and thus, the increase between the two olivine populations can be explained by fractional crystallization prior to eruption. Finally, based on our new data, we provide estimates on the total volatile emission of the eruption.
A Synoptic View of Mantle Plume Shapes Enabled by Virtual Reality
Authors: Lu Qianyi , Rudolph Maxwell L. 
Published: June 2024

AbstractThe shapes of mantle plumes are sensitive to mantle viscosity, density structure, and flow patterns. Increasingly, global tomographic models reveal broad plume conduits in the lower mantle and highly tilting conduits in the mid and upper mantle. Previous studies mostly relied on 2D slices to analyze plume shapes, but fully investigating the complexity of 3D plume structures requires more effective visualization methods. Here, we use immersive headset‐based virtual reality (VR) to visualize the full‐waveform global tomographic models SEMUCB‐WM1 and GLAD‐M25. We develop criteria for the identification of plume conduits based on the relationship between the plume excess temperature and the VS anomaly (δVS). We trace 20 major plume conduits, measure the offsets of the conduits in azimuth and distance with respect to the hotspots, calculate the tilt angle, and evaluate the δVS along all traced conduits. We compare our traced conduits with the conduits predicted by global mantle convection models and vertical conduits. The wavespeed variations along conduits traced from each tomographic model are slower than modeled or vertical conduits, regardless of which tomographic model they are evaluated in. The shapes of traced conduits tend to differ greatly from modeled conduits. Plume ponding and the emergence of secondary plumes, which could result from a combination of compositional variations, phase transitions, small‐scale convection, and variations in viscosity, can contribute to the complex observed plume shapes. The variation of δVS along the traced conduits and complex plume shapes suggest a thermochemical origin of many plumes.
Microbial Autotrophy Recorded by Carbonate Dual Clumped Isotope Disequilibrium
Authors: Ingalls Miquela , Leapaldt Hanna C. , Lloyd Max K. 
Published: June 2024

AbstractThe proliferation of microbial carbon fixation is a key control on the evolution of the biosphere and global carbon cycle. Most records of these metabolisms in ancient rocks come from organic matter or fossils, which are not always preserved. Here, we present a potential proxy for microbial carbon fixation (autotrophy) based on the isotopic composition of carbonate minerals. Autotrophs influence carbonate chemistry in the cellular microenvironment by decreasing CO2 concentration and increasing the carbonate saturation state. This can induce rapid precipitation of carbonate minerals that are out of isotopic equilibrium with their environment. Recent work has identified disequilibrated dual clumped isotope compositions (∆47 and ∆48) in the skeletal fossils of marine calcifying organisms. Here we test whether the same is true of non‐skeletal carbonate fabrics associated with microbial autotrophs in modern and Eocene lakes. We found that microbial carbonate formed via autotrophic metabolism recorded lower ∆47 and higher ∆48 values (−∆47/+∆48) than predicted for thermodynamic equilibrium mineral formation. Our findings are supported by models of dual clumped isotope kinetics in the DIC system, and disequilibrium in the oxygen isotope system. We hypothesize that the inverse trajectory away from the equilibrium line (+∆47/−∆48) should be recorded by carbonates formed in association with alkalinizing heterotrophs, such as sulfate reducers. If so, carbonate dual clumped isotopes could be a powerful tool to identify the proliferation and rate of heterotrophic and autotrophic metabolisms in the carbonate rock record on Earth and (perhaps) other planets.
Guidelines for Managing Radon Hazards in Tourist Volcanic Caves in Spain
Authors: Hernández‐Gutiérrez Luis E. , Calderón‐Guerrero Carlos , Martín‐Rosales Wenceslao , Rodríguez‐Martín Jesica , Cruz‐Pérez Noelia , Hernández‐Martín Helena , García‐Gil Alejandro , Santamarta Juan C. 
Published: June 2024

AbstractTourist volcanic caves are in high demand for ecotourism and geotourism lovers, as well as by sun and beach tourists as a complementary activity during their holidays. There are six tourist volcanic caves in the Canary Islands, all of them managed by the local administration of the island. The managers of these caves must ensure the safety of visitors and workers, who are exposed to natural hazards, such as radon, inherent to the environment in which the activity takes place. The methodology for analyzing natural radon radiation is based on the latest studies published by experts in this field and on previous experiences in tourist caves. This article proposes a protocol for the correct management of radon in tourist caves in the Canary Islands, adapted to current regulations, to mitigate effects on the health of visitors and workers.
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer
Authors: Saatci Ozge , Alam Rashedul , Huynh-Dam Kim-Tuyen , Isik Aynur , Uner Meral , Belder Nevin , Ersan Pelin Gulizar , Tokat Unal Metin , Ulukan Burge , Cetin Metin , Calisir Kubra , Gedik Mustafa Emre , Bal Hilal , Sener Sahin Ozlem , Riazalhosseini Yasser , Thieffry Denis , Gautheret Daniel , Ogretmen Besim , Aksoy Sercan , Uner Aysegul , Akyol Aytekin , Sahin Ozgur 
Published: June 2024

AbstractTamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER + ) breast cancer, constituting around 75% of all cases. However, the emergence of resistance is common, necessitating the identification of novel therapeutic targets. Here, we demonstrated that long-noncoding RNA LINC00152 confers tamoxifen resistance by blocking tamoxifen-induced ferroptosis, an iron-mediated cell death. Mechanistically, inhibiting LINC00152 reduces the mRNA stability of phosphodiesterase 4D (PDE4D), leading to activation of the cAMP/PKA/CREB axis and increased expression of the TRPC1 Ca2+ channel. This causes cytosolic Ca2+ overload and generation of reactive oxygen species (ROS) that is, on the one hand, accompanied by downregulation of FTH1, a member of the iron sequestration unit, thus increasing intracellular Fe2+ levels; and on the other hand, inhibition of the peroxidase activity upon reduced GPX4 and xCT levels, in part by cAMP/CREB. These ultimately restore tamoxifen-dependent lipid peroxidation and ferroptotic cell death which are reversed upon chelating Ca2+ or overexpressing GPX4 or xCT. Overexpressing PDE4D reverses LINC00152 inhibition-mediated tamoxifen sensitization by de-activating the cAMP/Ca2+/ferroptosis axis. Importantly, high LINC00152 expression is significantly correlated with high PDE4D/low ferroptosis and worse survival in multiple cohorts of tamoxifen- or tamoxifen-containing endocrine therapy-treated ER+ breast cancer patients. Overall, we identified LINC00152 inhibition as a novel mechanism of tamoxifen sensitization via restoring tamoxifen-dependent ferroptosis upon destabilizing PDE4D, increasing cAMP and Ca2+ levels, thus leading to ROS generation and lipid peroxidation. Our findings reveal LINC00152 and its effectors as actionable therapeutic targets to improve clinical outcome in refractory ER+ breast cancer.
Golgi dispersal in cancer stem cells promotes chemoresistance of colorectal cancer via the Golgi stress response
Authors: Li Yangkun , Mu Lei , Li Yanqi , Mi Yulong , Hu Yibing , Li Xiaolan , Tao Deding , Qin Jichao 
Published: June 2024

AbstractChemotherapy is a crucial treatment for colorectal tumors. However, its efficacy is restricted by chemoresistance. Recently, Golgi dispersal has been suggested to be a potential response to chemotherapy, particularly to drugs that induce DNA damage. However, the underlying mechanisms by which Golgi dispersal enhances the capacity to resist DNA-damaging agents remain unclear. Here, we demonstrated that DNA-damaging agents triggered Golgi dispersal in colorectal cancer (CRC), and cancer stem cells (CSCs) possessed a greater degree of Golgi dispersal compared with differentiated cancer cells (non-CSCs). We further revealed that Golgi dispersal conferred resistance against the lethal effects of DNA-damaging agents. Momentously, Golgi dispersal activated the Golgi stress response via the PKCα/GSK3α/TFE3 axis, resulting in enhanced protein and vesicle trafficking, which facilitated drug efflux through ABCG2. Identification of Golgi dispersal indicated an unexpected pathway regulating chemoresistance in CRC.
Tripartite motif 8 promotes the progression of hepatocellular carcinoma via mediating ubiquitination of HNF1α
Authors: Peng Yu , Qian Hui , Xu Wen-Ping , Xiao Meng-Chao , Ding Chen-Hong , Liu Fang , Hong Huan-Yu , Liu Shu-Qing , Zhang Xin , Xie Wei-Fen 
Published: June 2024

AbstractTripartite motif 8 (TRIM8) is an E3 ligase that plays dual roles in various tumor types. The biological effects and underlying mechanism of TRIM8 in hepatocellular carcinoma (HCC) remain unknown. Hepatocyte nuclear factor 1α (HNF1α) is a key transcriptional factor that plays a significant role in regulating hepatocyte differentiation and liver function. The reduced expression of HNF1α is a critical event in the development of HCC, but the underlying mechanism for its degradation remains elusive. In this study, we discovered that the expression of TRIM8 was upregulated in HCC tissues, and was positively correlated with aggressive tumor behavior of HCC and shorter survival of HCC patients. Overexpression of TRIM8 promoted the proliferation, colony formation, invasion, and migration of HCC cells, while TRIM8 knockdown or knockout exerted the opposite effects. RNA sequencing revealed that TRIM8 knockout suppresses several cancer-related pathways, including Wnt/β-catenin and TGF-β signaling in HepG2 cells. TRIM8 directly interacts with HNF1α, promoting its degradation by catalyzing polyubiquitination on lysine 197 in HCC cells. Moreover, the cancer-promoting effects of TRIM8 in HCC were abolished by the HNF1α-K197R mutant in vitro and in vivo. These data demonstrated that TRIM8 plays an oncogenic role in HCC progression through mediating the ubiquitination of HNF1α and promoting its protein degradation, and suggests targeting TRIM8-HNF1α may provide a promising therapeutic strategy of HCC.
EHHADH deficiency regulates pexophagy and accelerates tubulointerstitial injury in diabetic kidney disease
Authors: Kan Shuyan , Hou Qing , Shi Jinsong , Zhang Mingchao , Xu Feng , Liu Zhihong , Jiang Song 
Published: June 2024

AbstractPeroxisomal l-bifunctional enzyme (EHHADH) plays a role in the classic peroxisomal fatty acid β-oxidation pathway; however, the relationship between EHHADH expression and diabetic kidney disease has not been well understood. Here, we found that endogenous EHHADH levels were strongly correlated with the progression and severity of diabetic nephropathy in T2D patients. EHHADH knockout mice exhibited worsened renal tubular injury in diabetic mice. Furthermore, EHHADH is a modulator of pexophagy. In renal tubular epithelial cells (RTECs) in vitro, the knockdown of EHHADH induced a dramatic loss of peroxisomes. The loss of peroxisomes in EHHADH-deficient RTECs was restored by either an autophagic inhibitor 3-methyladenine or bafilomycin A1 both in vitro and in vivo. NBR1 was required for pexophagy in EHHADH-knockdown cells, where the level of reactive oxygen species (ROS) was increased, while inhibition of ROS blocked pexophagy. In summary, our findings revealed EHHADH deficiency accelerated renal injury in DKD as a modulator of pexophagy.
Microbiota succession influences nematode physiology in a beetle microcosm ecosystem
Authors: Lo Wen-Sui , Sommer Ralf J. , Han Ziduan 
Published: June 2024

AbstractUnravelling the multifaceted and bidirectional interactions between microbiota and host physiology represents a major scientific challenge. Here, we utilise the nematode model, Pristionchus pacificus, coupled to a laboratory-simulated decay process of its insect host, to mimic natural microbiota succession and investigate associated tripartite interactions. Metagenomics reveal that during initial decay stages, the population of vitamin B-producing bacteria diminishes, potentially due to a preferential selection by nematodes. As decay progresses to nutrient-depleted stages, bacteria with smaller genomes producing less nutrients become more prevalent. Lipid utilisation and dauer formation, representing key nematode survival strategies, are influenced by microbiota changes. Additionally, horizontally acquired cellulases extend the nematodes’ reproductive phase due to more efficient foraging. Lastly, the expressions of Pristionchus species-specific genes are more responsive to natural microbiota compared to conserved genes, suggesting their importance in the organisms’ adaptation to its ecological niche. In summary, we show the importance of microbial successions and their reciprocal interaction with nematodes for insect decay in semi-artificial ecosystems.
A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism
Authors: Mesa Deborah , Barbieri Elisa , Raimondi Andrea , Freddi Stefano , Miloro Giorgia , Jendrisek Gorana , Caldieri Giusi , Quarto Micaela , Schiano Lomoriello Irene , Malabarba Maria Grazia , Bresci Arianna , Manetti Francesco , Vernuccio Federico , Abdo Hind , Scita Giorgio , Lanzetti Letizia , Polli Dario , Tacchetti Carlo , Pinton Paolo , Bonora Massimo , Di Fiore Pier Paolo , Sigismund Sara 
Published: June 2024

AbstractOne open question in the biology of growth factor receptors is how a quantitative input (i.e., ligand concentration) is decoded by the cell to produce specific response(s). Here, we show that an EGFR endocytic mechanism, non-clathrin endocytosis (NCE), which is activated only at high ligand concentrations and targets receptor to degradation, requires a tripartite organelle platform involving the plasma membrane (PM), endoplasmic reticulum (ER) and mitochondria. At these contact sites, EGFR-dependent, ER-generated Ca2+ oscillations are sensed by mitochondria, leading to increased metabolism and ATP production. Locally released ATP is required for cortical actin remodeling and EGFR-NCE vesicle fission. The same biochemical circuitry is also needed for an effector function of EGFR, i.e., collective motility. The multiorganelle signaling platform herein described mediates direct communication between EGFR signaling and mitochondrial metabolism, and is predicted to have a broad impact on cell physiology as it is activated by another growth factor receptor, HGFR/MET.
Subthalamic nucleus input-output dynamics are correlated with Parkinson’s burden and treatment efficacy
Authors: Liu Xiaowei , Guang Jing , Glowinsky Stefanie , Abadi Hodaya , Arkadir David , Linetsky Eduard , Abu Snineh Muneer , León Juan F. , Israel Zvi , Wang Wei , Bergman Hagai 
Published: June 2024

AbstractThe subthalamic nucleus (STN) is pivotal in basal ganglia function in health and disease. Micro-electrode recordings of >25,000 recording sites from 146 Parkinson’s patients undergoing deep brain stimulation (DBS) allowed differentiation between subthalamic input, represented by local field potential (LFP), and output, reflected in spike discharge rate (SPK). As with many natural systems, STN neuronal activity exhibits power-law dynamics characterized by the exponent α. We, therefore, dissected STN data into aperiodic and periodic components using the Fitting Oscillations & One Over F (FOOOF) tool. STN LFP showed significantly higher aperiodic exponents than SPK. Additionally, SPK beta oscillations demonstrated a downward frequency shift compared to LFP. Finally, the STN aperiodic and spiking parameters explained a significant fraction of the variance of the burden and treatment efficacy of Parkinson’s disease. The unique STN input-output dynamics may clarify its role in Parkinson’s physiology and can be utilized in closed-loop DBS therapy.