bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical Decarboxylative Addition of N‐Aryl Glycines to Enaminones: Access to C3‐Aminomethyl Chromones
Authors: Han Siyang , Fang Chengcheng , Zhang Yaoge , Li Sifeng , Huang Min , Wang Taimin , An Baigang , Cheng Bin 
Published: May 2024

AbstractAn electrochemical decarboxylative addition of N‐substituted glycines to enaminones has been developed and conducted under oxidant‐, catalyst‐, and light‐free conditions in acetonitrile at room temperature by using electron as the traceless oxidant, which provided a green approach to access C3‐aminomethyl chromones. The resulting products were formed through radical addition/oxidation/cyclization or electrophilic addition/cyclization pathway and could act as valuable building blocks to construct polysubstituted pyrimidine derivatives.
Improving accuracy of estimating building capacity curves from acceleration data using SDOF analysis
Authors: Pham Quang‐Vinh , Kusunoki Koichi , Maida Yusuke , Yeow Trevor 
Published: May 2024

AbstractDisplacement response is critical data for post‐earthquake fast building assessment. However, directly measuring building displacement response remains a great challenge in practice. Therefore, it is practically common to estimate displacement response from acceleration response using double integration. Unfortunately, the low‐frequency component of displacement obtained by double integrating acceleration often contains noise that is indistinguishable from low‐frequency displacement components. Consequently, the maximum displacement estimated from acceleration is commonly underestimated in comparison to its true value due to the removal of the low‐frequency components. This can potentially lead to an underestimation of post‐earthquake building damage state, especially when a building undergoes significant nonlinear deformation. This study develops a framework to improve the accuracy of the maximum displacement obtained from floor acceleration data by fusing it with the low‐frequency displacement component estimated from an equivalent SDOF analysis for both reinforced concrete (RC) and steel structures. Procedures for constructing the equivalent SDOF model of a building and a procedure for extracting the low‐frequency component from the analysis displacement were developed. The proposed method was verified using a diverse range of case studies from numerical simulation and experimental studies under different seismic records for both RC and steel structures. The results showed that the proposed method was effective with a range of seismic characteristics and damage levels. A significant reduction in maximum displacement errors was observed for cases with significant nonlinear deformation, which may contribute to a more accurate post‐earthquake building assessment.
Climate‐resilient water infrastructure in India
Authors: Vohra Kushvinder , Saurabh  
Published: May 2024

AbstractIndia receives an annual precipitation of about 3880 BCM and the average water availability is 1999 BCM. Out of this, utilizable water resources are 1126 BCM due to topographic constraints, distribution effects and so forth. In India, agriculture remains the principal source of livelihood for about 54.6% of the population. The overall water demand of the country in 2010 was estimated at 710 BCM, of which the water use in irrigation was about 557 BCM (78%). With limited water resources available for fulfilling the water requirement of all the sectors, it is projected that by 2050 our overall water demand (1180 BCM) would outgrow the total utilizable water resources, namely 1126 BCM. Moreover, the groundwater table in various regions of the country is seeing a decline at an alarming rate.Additionally, climate change poses significant and far‐reaching threats in all spheres of life and the economy. The erratic rainfall pattern makes a significant contribution to the frequent occurrence of floods and droughts in the country.This paper attempts to put in context the impact of climate change observed on various facets of water resources, the need to develop and invest in climate‐resilient water infrastructure, and to highlight several initiatives taken by the government of India in this direction.
Surveillance colonoscopy findings in asymptomatic participants over 75 years of age
Authors: Agaciak Madelyn , Wassie Molla M , Simpson Kalindra , Cock Charles , Bampton Peter , Fraser Robert , Symonds Erin L 
Published: May 2024

AbstractBackground and AimSurveillance colonoscopy for colorectal cancer (CRC) is generally not recommended beyond 75 years of age. The study determined incidence and predictors of advanced adenoma and CRC in older individuals undergoing surveillance colonoscopy.MethodsThis was a retrospective cohort study of asymptomatic older participants (≥75 years), enrolled in a South Australian CRC surveillance program who underwent colonoscopy (2015–2020). Clinical records were extracted for demographics, personal or family history of CRC, comorbidities, polypharmacy, and colonoscopy findings. The associations between clinical variables and advanced adenoma or CRC at surveillance were assessed with multivariable Poisson regression analysis.ResultsTotally 698 surveillance colonoscopies were analyzed from 574 participants aged 75–91 years (55.6% male). The incidence of CRC was 1.6% (11/698), while 37.9% (260/698) of procedures had advanced adenoma detected. Previous CRC (incidence rate ratio [IRR] 5.9, 95% CI 1.5–22.5), age ≥85 years (IRR 5.8, 95% CI 1.6–20.1) and active smoking (IRR 4.9, 95% CI 1.0–24.4) were independently associated with CRC diagnosis, while advanced adenoma at immediately preceding colonoscopy (IRR 1.6, 95% CI 1.3–2.0) and polypharmacy (IRR 1.2, 95% CI 1.0–1.5) were associated with advanced adenoma at surveillance colonoscopy in asymptomatic older participants (≥75 years).ConclusionAdvanced neoplasia was found in more than one third of the surveillance procedures completed in this cohort. Continuation of surveillance beyond age 75 yeasrs may be considered in participants who have previous CRC or are active smokers (provided they are fit to undergo colonoscopy). In other cases, such as past advanced adenoma only, the need for ongoing surveillance should be considered alongside participant preference and health status.
mmu‐miR‐185 regulates osteoclasts differentiation and migration by targeting Btk
Authors: He Dan , Jiao Yueying , Xu Jian , Luo Junjie , Cui Yaqi , Han Xiabing , Zhao Hongshan 
Published: May 2024

AbstractBackgroundBones undergo a constant remodeling, a process involving osteoclast‐mediated bone resorption and osteoblast‐mediated bone formation, crucial for maintaining healthy bone mass. We previously observed that miR‐185 depletion may promote bone formation by regulating Bgn expression and the BMP/Smad signaling pathway. However, the effects of miR‐185‐5p on the osteoclasts and bone remodeling have not been elucidated, warranting further exploration.MethodsTartrate‐resistant acid phosphatase staining was utilized to assess the differentiation ability of bone marrow mononuclear macrophages (BMMs) from mmu‐miR‐185 gene knockout (KO) mice and wild‐type (WT) mice. A reverse transcriptase‐quantitative PCR was conducted to compare differences in miR‐185‐5p and osteoclast marker molecules, including Trap, Dcstamp, Ctsk and Nfatc1, between the KO group and WT group BMMs. Western blot analysis was employed to observe the expression of osteoclast marker molecules. A cell‐counting kit‐8 was used to analyze cell proliferation ability. Transwell experiments were conducted to detect cell migration. Dual‐luciferase reporter assays were employed to confirm whether Btk is a downstream target gene of miR‐185‐5p.ResultsmiR‐185 depletion promoted osteoclast differentiation in bone marrow‐derived monocytes/macrophages. Overexpression of miR‐185‐5p in RAW264.7 cells inhibited differentiation and migration of osteoclasts. Furthermore, Btk was identified as a downstream target gene of miR‐185‐5p, suggesting that miR‐185‐5p may inhibit osteoclast differentiation and migration by targeting Btk.ConclusionsmiR‐185 regulates osteoclasts differentiation, with overexpression of miR‐185‐5p inhibiting osteoclast differentiation and migration in vitro. Additionally, miR‐185‐5p may modulate osteoclastic differentiation and migration by regulating Btk expression.
両下腿の安静時痛が初発症状であった巨細胞性動脈炎の1例(Giant cell arteritis presenting as bilateral calf rest pain: a case report)
Authors: 拓也 西沢 , 聡司 吉川 , 剛士 上田 
Published: May 2024

要旨巨細胞性動脈炎（giant cell arteritis: GCA）は，高齢者に好発する大血管炎で，視力予後に関わるため，見逃してはいけない疾患の一つである。症例は85歳の男性。発熱を伴う両下腿の安静時痛を主訴に当院搬送された。両側の下腿腫脹を認めたが，把握痛や浮腫，発赤は認めず，下肢静脈超音波検査でも深部静脈血栓は指摘できなかった。血液検査で高度な炎症所見を認め，下肢の造影CTで両側の大腿動脈から膝窩動脈にかけて，動脈壁肥厚と動脈周囲の脂肪織濃度の上昇を認めた。再度診察したところ，右鎖骨下動脈と左浅大腿動脈に沿った圧痛を認めた。動脈超音波検査で，大腿・膝窩を含む動脈にびまん性壁肥厚を認めたため，GCAと臨床診断した。両下腿の安静時痛が初発症状であるGCAは非典型例ではあったが，動脈の圧痛や，画像検査で血管壁肥厚の有無を確認したことが早期診断の一助となった。
乳児感染性硬膜下血腫の1例(A case of infantile infected subdural hematoma)
Authors: 旬 内田 , 靖一 小守林 , 貴之 千葉 , 普 柳原 , 司 和田 , 智彦 眞瀬 , 邦昭 小笠原 
Published: May 2024

要旨乳児の感染性硬膜下血腫は稀であり，開頭術と穿頭術のどちらが優れているのかについて結論は得られていない。症例は虐待が疑われる6か月の男児である。生後5か月時に両側慢性硬膜下血腫を認め，CT上脳実質への圧迫はなく経過観察としていた。1か月後に突然の意識障害が出現し，CT上右硬膜下血腫の増大を認めた。重度の貧血があったため開頭術はリスクが高いと判断し，大泉門穿刺による血腫吸引を施行した。吸引した血腫を検鏡したところ，グラム陽性球菌の貪食像を認めた。抗菌薬投与下に，連日大泉門穿刺を行った。全身状態が改善した発症14病日に全身麻酔による内視鏡下頭蓋内血腫除去術を施行した。血腫腔内部は肉芽組織の隔壁が増生していた。隔壁を破りつつ血腫を吸引し，血腫腔を単房化した。術後経過は良好で硬膜下血腫の再発は認めなかった。感染性硬膜下血腫では画像上明らかでない隔壁形成が血腫腔内に存在する可能性があり，内視鏡補助下に血腫腔内を単房化しつつ血腫を除去することで，感染をコントロールできる可能性が示唆された。
Linalool‐zinc oxide nanocomposite controls Toxoplasma gondii infection through inhibiting inflammation, oxidative stress, and pathogenicity
Authors: Baghdadi Hanadi B. A. , Albalawi Aishah E. , Shater Abdullah F. , Almohammed Hamdan , Alanazi Abdullah D. 
Published: May 2024

AbstractThe present in vitro and in vivo study aimed to fabricate and characterize linalool‐zinc oxide nanoparticles (Lin‐ZNP) and evaluate their effectiveness against Toxoplasma gondii infection in terms of inflammation, oxidative stress, and pathogenicity. Lin‐ZNP was synthesized using an ethanolic solution of polyvinyl alcohol. The anti‐Toxoplasma and cytotoxicity activities of Lin‐ZNP were investigated, along with its effects on nitric oxide (NO) production, caspase‐3 activity, and pro‐inflammatory genes. After treating T. gondii‐infected mice with Lin‐ZNP for 14 days, the number and size of tissue cysts, antioxidant potential, pro‐inflammatory cytokines, and T. gondii pathogenicity‐related genes were evaluated by real‐time polymerase chain reaction and Western blot analysis. The Lin‐ZNP composite showed a reduced tendency with an average size of 105 nm. Lin‐ZNP significantly reduced the viability of tachyzoites. The obtained selectivity index higher than 10, indicating high specificity for parasites with low cytotoxicity to normal cells. The Lin‐ZNP significantly (p < 0.05) increased the production of NO, caspase‐3 activity, and the expression levels of pro‐inflammatory genes. Lin‐ZNP significantly (p < 0.001) decreased the size and number of tissue cysts and caused a significant reduction in the level of malondialdehyde and a considerable increase (p < 0.001) in antioxidant enzymes and their expression genes. Lin‐ZNP significantly downregulated both mRNA and protein expression of the inflammation‐related markers associated with the TLRs/NF‐κB pathway. The expression levels of the T. gondii pathogenicity‐related genes were significantly downregulated (p < 0.05). The recent survey indicated that Lin‐ZNP manages T. gondii infection by its antioxidant activity and inhibiting the TLRs/NF‐κB pathway without toxicity in mice.
Contributions of Metacognition to Creative Performance and Behavior
Authors: Lebuda Izabela , Benedek Mathias 
Published: May 2024

ABSTRACTHow are ideas born? Contrary to commonly held beliefs, creative performance, like any goal‐oriented action, requires understanding and managing one's own cognitive processes – thus, efficient metacognition. Recently, a systematic framework of creative metacognition (CMC) has been proposed, assuming the relevance of metacognitive knowledge, monitoring, and control in creative performance. Here, we provide the first comprehensive empirical examination of this conception. Specifically, an online sample (N = 425) performed divergent thinking (DT) tasks and gave insight in relevant aspects of metacognitive processes during task performance. The study revealed that all three proposed components of CMC played independent roles in enhancing creative cognitive performance, including divergent thinking creativity and fluency. Among these components, metacognitive control showed the strongest positive association with creative cognitive performance. As expected, CMC was especially relevant to imminent creative task performance but showed some association with real‐life creativity. These findings provide the first empirical evidence that all three postulated components of CMC support creative performance and, to a lesser degree, to creative behavior. In the discussion, we delve deeper into the specific roles of these metacognitive subcomponents in enhancing creative cognitive performance and touch upon the differences between the roles of self‐regulation and metacognition in creativity.
Reeling in Stories: An Investigation of Creative Behaviors and Creativity‐Support on Instagram
Authors: Ceh Simon M. , Benedek Mathias 
Published: May 2024

ABSTRACTCreative behaviors are increasingly impacted by digital technologies, but little is known about the way digital technologies support everyday creativity and what factors predict their creative use. We investigated to what extent individual differences in person‐specific (creativity, personality) and platform‐specific (e.g., perceived creativity support) characteristics relate to the creative use of Instagram. The results from a sample of 191 Instagram users revealed that more frequent creative use of Instagram was related to greater engagement in everyday creative behaviors, creative self‐beliefs, the openness facet of creative imagination, extraversion, a more positive attitude toward Instagram, greater platform‐related self‐efficacy, and greater perceived creativity‐support. Regression analysis further revealed a unique contribution of everyday creativity, creative personal identity, extraversion, attitude toward Instagram, Instagram self‐efficacy, and perceived creativity‐support for creative use of Instagram. Although creativity was not the most central motive for using Instagram, the results from the present study indicated considerable levels of creative use, suggesting that common online spheres are important for everyday creative behavior. Together, this study identified relevant person‐ and platform‐specific factors predicting creative behavior at Instagram, while also highlighting the relevance of creativity in the digital world even outside of devoted digital creativity tools.
Improving aromatic higher alcohol acetates in wines by co‐fermentation of Pichia kluyveri and Saccharomyces cerevisiae: growth interaction and amino acid competition
Authors: Li Yueqi , Xu Lingbin , Sam Faisal Eudes , Li Aihua , Hu Kai , Tao Yongsheng 
Published: May 2024

AbstractBACKGROUNDHigher alcohol acetates (HAAs) are potent aroma‐active esters that impart desirable fruity and floral aromas. However, the conversion of higher alcohol precursors into HAAs is extremely low in winemaking. To investigate the underlying yeast–yeast interaction on targeted improvement of aromatic HAAs, we evaluated fermentation activity, cell viability, amino acid consumption and HAA production when Pichia kluyveri and Saccharomyces cerevisiae were inoculated concurrently or sequentially.RESULTSPichia kluyveri PK‐21 possessed the ability to survive and increased HAA level up to 5.2‐fold in mixed fermentation. Such an increment may benefit from the efficient conversion of higher alcohol precursors into HAAs (>27‐fold higher than S. cerevisiae). During mixed fermentation, the two yeasts exhibited crucial interactions regarding cell growth and amino acid competition. Saccharomyces cerevisiae dominated over the co‐inoculated P. kluyveri by efficient uptake of amino acids and biomass production. However, this dominance decreased in sequential fermentation, where P. kluyveri growth increased due to the consumption of preferred amino acids prior to S. cerevisiae. Pearson correlation analysis indicated that phenylalanine and aspartic acid may act as positive amino acids in boosting P. kluyveri growth and HAA production. Laboratory‐scale winemaking validated the fermentation performance of P. kluyveri in sequential inoculum, resulting in a balanced aroma profile with enhanced floral and tropical fruity characteristics in the final wines.CONCLUSIONThis study proposes a microbial, non‐genetically engineered approach for targeted increase of HAA production in winemaking and the findings provide new insights into yeast–yeast interactions. © 2024 Society of Chemical Industry.
Cover Image
Authors: Wang Xuecheng , Wang Xiaohui , Zhang Yutian , Wang Yaqi , Li Yuanhui , Xiong Yaokun , Yang Ming , Luo Xiaorong , Wu Zhenfeng 
Published: May 2024

The cover image is based on the Research Article Effects of ultrasonic power on drying kinetics and product quality of licorice extract during ultrasound‐assisted vacuum drying by Xuecheng Wang et al., https://doi.org/10.1002/jsfa.13283.
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Female patients have greater improvement in pain symptoms and physical activity after fasciotomy for treatment of chronic exertional compartment syndrome of the lower leg
Authors: Shankar Dhruv S. , Vasavada Kinjal D. , Gillinov Lauren A. , Kirschner Noah , Mojica Edward S. , Blaeser Anna M. , Borowski Lauren E. , Jazrawi Laith M. , Cardone Dennis A. 
Published: May 2024

AbstractPurposeThe purpose of this study was to identify sex differences in postoperative outcomes and return‐to‐sport rates after fasciotomy for treatment of chronic exertional compartment syndrome (CECS) of the lower leg. It was hypothesised that male CECS patients would have a higher rate of return to sport than female CECS patients.MethodsA retrospective cohort study was conducted involving patients who underwent primary fasciotomy of one to four leg compartments for treatment of CECS at a single centre from 2010 to 2020. Each affected leg was treated as a separate subject. Postoperative outcomes included CECS pain frequency and severity, return to sport and Tegner activity level. Multivariable regression was used to determine if sex was an independent predictor of outcomes after adjusting for demographic and clinical covariates. p < 0.05 were considered significant.ResultsEighty‐one legs (44 M, 37 F) of 47 unique patients (34 of whom had bilateral symptoms) were included with a mean follow‐up time of 51.5 ± 31.4 months. Male subjects were older (p < 0.001) and had higher body mass index (p < 0.001) compared to female subjects. Most subjects (84.0%) underwent two‐ or four‐compartment fasciotomies. Female sex was found to be predictive of lower overall postoperative pain severity (p = 0.007), higher odds of return to sport (p = 0.04) and higher postoperative Tegner score (p = 0.005). However, female sex was not predictive of postoperative pain frequency, odds of reoperation or odds of return to sport to at least the presymptomatic level (all p < 0.05).ConclusionFemale sex is independently predictive of reduced overall pain severity, higher odds of return to sport and higher postoperative improvement in Tegner score following fasciotomy for treatment of lower‐limb CECS.Level of EvidenceIII.
Fabrication and mechanical properties of thermoplastic corrugated sandwich panel with enhanced face‐core interface
Authors: Zhang Yan , Qin Weiming , Chen Liming , Du Bing , Zhu Shaowei , Liu Tao , Hou Xianbo 
Published: May 2024

AbstractThermoplastic sandwich structures are widely utilized in engineering fields due to their high specific strength and stiffness, recyclability, and impact toughness. The face‐core interface strength is crucial to maximize the performance benefits of sandwich structures. Two sizes of corrugated sandwich panels with hot‐melt bonding and resistance welding connection methods were fabricated. The mechanical properties of sandwich panels were compared using a combination of experimental, numerical, and analytical investigation. Edgewise compression (EC) and 3‐point bending (3 PB) tests were conducted to obtain load–displacement curves and investigate different failure modes of sandwich panels. The peak edge compression and bending loads of the resistance welded structures were 42% and 92% higher, respectively, and the face‐core interface was always well‐connected compared to those of the hot‐melt bonding. The results indicate that the resistance welding method can be utilized as a core bonding technique for thermoplastic composite sandwich structures and has great potential for aerospace application.Highlights
A method that includes hot‐melt bonding and resistance welding are develop to produce thermoplastic composite corrugated sandwich panels (TPC‐CSPs).
The TPC‐CSPs fabricated by resistance welding exhibit superior interface connection performance compared to hot‐melt bonding and this method enhance the structural load bearing capacity.
The numerical and analytical method were presented to investigate the failure model, which was consistent with the experimental results.
Optimized random forest model for predicting flexural properties of sustainable composites
Authors: Mahajan Aditi , Gairola Sandeep , Singh Inderdeep , Arora Navneet 
Published: May 2024

AbstractIn an era of technological advancements, the quest for sustainable products has taken a center stage. The utilization of natural fiber reinforced polymer composites has become crucial in the manufacturing of eco‐friendly products due to their low cost, renewability, biodegradability, and comparable properties to synthetic composites. Coir‐based composites have been utilized in roofing, composite panels, furniture, and bio‐based insulation applications, providing enhanced strength and sustainability. In the current investigation, an exploratory data analysis (EDA) was conducted to understand the relationship between the various input variables and the flexural properties of short coir polymer composites (SCPCs). The data analysis revealed that manufacturing process had a significant impact on the flexural properties of SCPCs. Based on the insights gained from the EDA, an optimized Random Forest prediction model was developed to predict the flexural properties. Genetic algorithm approach for hyperparameter optimization led to lower objective loss in contrast to Bayesian optimized Random Forest model. The model's performance was subsequently evaluated through holdout validation, and the outcome demonstrated the model's proficiency in accurately predicting the properties. The developed model can be used as a tool for optimizing the design of SCPCs for specific applications, by predicting the flexural properties of the composites.Highlights
Flexural behavior of short coir polymer composites was analyzed and modeled.
Manufacturing process has the highest impact on the flexural properties.
Random forest model predicted the flexural properties with high accuracy.
Genetic algorithm optimized model further enhanced the model performance.
The developed framework provides insights into designing biocomposites.