bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: C2‐Symmetric Pyrrolidine‐Based Chiral Ammonium Salts as a Phase‐Transfer Catalyst.
Authors: Ishikawa Tatsuya , Nagata Kazuhiro , Kani Sachiko , Matsuo Mamoru , Sano Daisuke , Kanemitsu Takuya , Miyazaki Michiko , Itoh Takashi 
Published: February 2012

AbstractPyrrolidinium salts, e.g. (I), are developed as novel chiral phase‐transfer catalysts with a more simplified structure.
ChemInform Abstract: Convenient Synthesis and Isolation of Trifluoromethylthio‐Substituted Building Blocks.
Authors: Harsanyi Antal , Dorko Eva , Csapo Agnes , Bako Tibor , Peltz Csaba , Rabai Jozsef 
Published: February 2012

AbstractThe convenient and efficient protocol presented affords trifluoromethyl sulfides (III) in fair to good yields.
ChemInform Abstract: (E)‐Selective Isomerization of Stilbenes and Stilbenoids Through Reversible Hydroboration.
Authors: Gray Erin E. , Rabenold Lake E. , Goess Brian C. 
Published: February 2012

AbstractA novel variant concerning hydroboration of stilbenes is developed and the process is applied to convert E/Z‐mixtures stereoselectively to the (E)‐isomers including the trimethyl derivative (Va) of resveratrol (Vb).
ChemInform Abstract: CuI/PPh3/PEG—Water: An Efficient Catalytic System for Cross‐Coupling Reaction of Aryl Iodides and Alkynes.
Authors: Chen Gong , Xie Jianwei , Weng Jiang , Zhu Xinhai , Zheng Zhanchao , Cai Jiwen , Wan Yiqian 
Published: February 2012

AbstractAryl iodides and terminal alkynes are coupled under microwave irradiation using the catalytic system CuI/PPh3/PEG—Water.
ChemInform Abstract: An Efficient Protocol for Copper‐Free Palladium‐Catalyzed Sonogashira Cross‐Coupling in Aqueous Media at Low Temperatures.
Authors: Marziale Alexander N. , Schlueter Johannes , Eppinger Joerg 
Published: February 2012

AbstractAryl iodides are more reactive than the bromides and various substrates can be successfully coupled under conditions A).
ChemInform Abstract: Cationic Palladium(II)‐Catalyzed Synthesis of 2‐Substituted 3‐Hydroxymethylbenzo[b]furans.
Authors: Wang Huan , Han Xiuling , Lu Xiyan 
Published: February 2012

AbstractStarting from readily accessible 2‐alkynylphenols and aldehydes, a novel process is developed which can be extended to other activated carbonyl compounds.
ChemInform Abstract: Iodine‐Catalyzed Conjugate Addition of Indoles onto En‐1,4‐dione: A Novel Synthesis of 3‐(1‐(1H‐Indol‐3‐yl)‐2‐oxo‐2‐phenylethyl)indolin‐2‐ones as Antibacterial and Antifungal Agents.
Authors: Reddy B. V. Subba , Rajeswari N. , Sarangapani M. , Reddy G. Roopa , Madan Ch. , Kumar K. Pranay , Rao M. Srinivasa 
Published: February 2012

AbstractSome of the compounds synthesized show moderate antibacterial and antifungal properties.
ChemInform Abstract: A Tandem Route to the Synthesis of Carbazolo[1,2‐b]carbazoles.
Authors: Chaitanya T. Krishna , Nagarajan Rajagopal 
Published: February 2012

AbstractSequential Michael addition of 2‐methylindole to the carbazole‐type substrates (I), dehydration of the methyl group with the carbonyl group, and subsequent dehydration/ aromatization provides moderate yields of the title compounds (III), which represent the skeleton of carbazole alkaloids.
ChemInform Abstract: Design and Synthesis of 2‐(1,3‐Dioxoisoindolin‐2‐yl)‐N‐(4‐oxo‐2‐substitutedthiazolidin‐3‐yl) Acetamide Derivatives as Potential Anticonvulsant Agents.
Authors: Nikalje Anna Pratima G. , Khan Firoz Kalam , Ghodke Mangesh 
Published: February 2012

AbstractKeeping in view the pharmacophoric requirement, the title derivatives (III) are synthesized by coupling the dioxoindolin moiety with the thiazolidinone nucleus, linked by an amide spacer.
ChemInform Abstract: A One‐Pot Efficient Four‐Component Reaction for the Synthesis of 2‐(Arylamino)‐2‐(5‐aryl‐1,3,4‐oxadiazol‐2‐yl)propyl Benzoate (or Acetate) Derivatives.
Authors: Ramazani Ali , Ahmadi Yavar , Malekzadeh Asemeh Mashhadi , Rezaei Aram 
Published: February 2012

AbstractThe multicomponent reaction between oxopropylbenzoate(acetate) (I), (VI), primary amines (II), (N‐isocyanimino)triphenylphosphorane (III), and aromatic carboxylic acids (IV) proceeds smoothly at room temperature under neutral conditions to afford the sterically congested oxadiazole derivatives (V) and (VII), resp.
ChemInform Abstract: Chiral Pyridin‐3‐ones and Pyridines: Syntheses of Enantiopure 2,4‐Disubstituted 6‐Hydroxy‐1,6‐dihydro‐2H‐pyridin‐3‐ones, 2,3‐Disubstituted 4‐Iodopyridines, and Enantiopure 2,3‐Disubstituted 4‐Pyridinemethanols.
Authors: Husain Irfan , Saquib Mohammad , Bajpai Vikas , Kumar Brijesh , Shaw Arun K. 
Published: February 2012

AbstractA new route to enantiopure dihydropyridines of type (VI) and (XIII) is reported.
ChemInform Abstract: Broensted Acid‐Catalyzed Enantioselective Friedlaender Condensations: Achiral Amine Promoter Plays Crucial Role in the Stereocontrol.
Authors: Ren Lei , Lei Tao , Gong Liu‐Zhu 
Published: February 2012

AbstractUse of 2‐naphthylamine as promoter in the enantioselective Friedlaender condensation of o‐aminobenzaldehydes with p‐substituted cyclohexanones provides access to tetrahydroacridine derivatives in high yields and excellent enantioselectivity (up to 95%).
ChemInform Abstract: Investigation Towards an Efficient Synthesis of Benzo[g]isoquinoline‐1,5,10(2H)‐triones.
Authors: Mbala Blaise Mavinga , Jacob Jan , Claes Pieter , Mudogo Virima , De Kimpe Norbert 
Published: February 2012

AbstractA two‐step synthesis of trioxo‐tetrahydrobenzoisoquinolinecarboxylates (III) is achieved by oxidative coupling of dihydroxynaphthalenecarboxylate (I) with enaminoesters (II) followed by cyclization reaction.
ChemInform Abstract: Efficient Access to Novel Hexahydro‐chromene and Tetrahydro‐pyrano[2,3‐d]pyrimidine‐annulated Benzo‐δ‐sultones via a Domino Knoevenagel‐hetero‐Diels—Alder Reaction in Water.
Authors: Ghandi Mehdi , Mohammadimehr Elham , Sadeghzadeh Masoud , Bozcheloei Abolfazl Hasani 
Published: February 2012

AbstractA one‐pot synthetic approach for the preparation of the title compounds in water under catalyst‐free conditions is reported.
ChemInform Abstract: Design of Potent and Selective GPR119 Agonists for Type II Diabetes.
Authors: Szewczyk Jason W. , et al. et al. 
Published: February 2012

AbstractDual termini optimization of a bis‐piperidine‐based GPR119 agonist affords an analogue possessing improved potency, selectivity, and formulation profile, but modest physical properties.
ChemInform Abstract: Design and Synthesis of Novel Pyrazole‐Based Lp‐PLA2 Inhibitors.
Authors: Wang Yi , Xu Weiren , Shao Hua , Xie Yafei , Wang Jianwu 
Published: February 2012

AbstractA 10‐step convergent synthesis of a series of novel pyrazole‐based lipoprotein‐associated phospholipase A2 inhibitors (X) (5 examples) is described.
ChemInform Abstract: Lewis Acid Promoted Three‐Component Reactions of Propargylic Alcohols with 2‐Butynedioates and Secondary Amines.
Authors: Yin Guangwei , Zhu Yuanxun , Lu Ping , Wang Yanguang 
Published: February 2012

AbstractThe title reaction allows a new and efficient method to prepare functionalized dihydroazepines.
ChemInform Abstract: Asymmetric Synthesis of Enantiomerically Pure 1,4‐Di‐ and 1,1,4‐Trisubstituted Tetrahydro‐1H‐3‐benzazepines.
Authors: Sarkar Soumya , Schepmann Dirk , Wuensch Bernhard 
Published: February 2012

AbstractEnantiomerically pure 3‐benzazepines such as (V), (XI), or (XIV) are prepared from tricyclic lactams (I) or (VI).
ChemInform Abstract: Catalyst‐Free Regioselective Hydrostannation of Arynes.
Authors: Spiteri Christian , Burnley James , Moses John E. 
Published: February 2012

AbstractArynes, generated in situ from o‐trimethylsilylphenyl triflates or anthranilic acid, undergo regioselective hydrostannation with tributyl‐ or triphenyltin hydride in one pot.
ChemInform Abstract: Synthesis and Bioactivities of Andrographolide Derivatives: New (—)‐Limonidilactone Analogues.
Authors: Xu Haiwei , Jiang Pingjuan , Li Weiyi , Wang Junfeng , Liu Hongmin 
Published: February 2012

AbstractThe key‐step of the respective syntheses is an oxo‐Michael addition reaction.
ChemInform Abstract: Selective Cholinesterase Inhibition by Lanostane Triterpenes from Fruiting Bodies of Ganoderma lucidum.
Authors: Lee IkSoo , Ahn BoRa , Choi JaeSue , Hattori Masao , Min ByungSun , Bae KiHwan 
Published: February 2012

AbstractTwo new lanostane triterpenes, methyl ganoderate A acetonide (I) and butyl ganoderate H (II) are isolated from the fruiting bodies of Ganoderma lucidum along with 16 known compounds.
ChemInform Abstract: Reproductive Regulating Pheromones of Queen Ant: A Short and Versatile Synthesis of 3,11‐Dimethylheptacosane (VII)
Authors: Lee Jinwoo , Lee Hwajong , Sohn Jeong‐Hun 
Published: February 2012

Abstractinvolving metathesis reactions for the preparation of diene fragments (III) and (V) as the key steps
ChemInform Abstract: Modulation of the Catalytic Activity of Porphyrins by Lipid‐ and Surfactant‐Containing Nanostructures
Authors: Nantes Iseli L. , Duran Nelson , Pinto Sandra M. S. , da Silva Fabiana B. , de Souza Juliana S. , Isoda Noemia , Luz Roberto A. S. , de Oliveira Tiara G. , Fernandes Vinicius G. 
Published: February 2012

AbstractReview: 82 refs.
Electrophoretic Deposition of a Reduced Graphene–Au Nanoparticle Composite Film as Counter Electrode for CdS Quantum Dot‐Sensitized Solar Cells
Authors: Zhu Guang , Pan Likun , Sun Hengchao , Liu Xinjuan , Lv Tian , Lu Ting , Yang Jie , Sun Zhuo 
Published: February 2012

AbstractA reduced graphene (RG)‐Au nanoparticle composite film is successfully fabricated by electrophoretic deposition and used as counter electrode for quantum dot‐sensitized solar cells. The RG‐Au composite is prepared by one‐step microwave‐assisted reduction of chloroaurate in alkaline solution with graphite oxide dispersion. Under one sun illumination (AM 1.5 G, 100 mW cm−2), the cell with a RG‐Au counter electrode shows an energy conversion efficiency of 1.36 %, which is higher than those of cells employing conventional Pt or Au counter electrodes, due to the superior combination of highly catalytic Au nanoparticles and the conductive graphene network structure.
Water Oxidation by Electrodeposited Cobalt Oxides—Role of Anions and Redox‐Inert Cations in Structure and Function of the Amorphous Catalyst
Authors: Risch Marcel , Klingan Katharina , Ringleb Franziska , Chernev Petko , Zaharieva Ivelina , Fischer Anna , Dau Holger 
Published: February 2012

AbstractFor the production of nonfossil fuels, water oxidation by inexpensive cobalt‐based catalysts is of high interest. Films for the electrocatalysis of water oxidation were obtained by oxidative self‐assembly (electrodeposition) from aqueous solutions containing, apart from Co, either K, Li or Ca with either a phosphate, acetate or chloride anion. X‐ray absorption spectroscopy (XAS) at the Co K‐edge revealed clusters of edge‐sharing CoO6 octahedra in all films, but the size or structural disorder of the Co‐oxido clusters differed. Whereas potassium binding is largely unspecific, CaCo3O4 cubanes, which resemble the CaMn3O4 cubane of the biological catalyst in oxygenic photosynthesis, may form, as suggested by XAS at the Ca K‐edge. Cyclic voltammograms in a potassium phosphate buffer at pH 7 revealed that no specific combination of anions and redox‐inactive cations is required for catalytic water oxidation. However, the anion type modulates not only the size (or order) of the Co‐oxido clusters, but also electrodeposition rates, redox potentials, the capacity for oxidative charging, and catalytic currents. On these grounds, structure–activity relations are discussed.
Amphiphilic EuDOTA‐Tetraamide Complexes Form Micelles with Enhanced CEST Sensitivity
Authors: Evbuomwan Osasere M. , Kiefer Garry , Sherry A. Dean 
Published: February 2012

AbstractThe synthesis and characterization of four new DOTA‐tetraamide ligands having variable alkyl chain lengths (C1, C12, C14, and C16) and their respective europium(III) complexes are reported. The three EuL complexes having long alkyl chains spontaneously form micelles of variable size. The critical micelle concentration differed for each complex (lower for the C16 complex than the C12 complex) while micelle size increased with increasing alkyl chain length. Chemical exchange saturation transfer (CEST) experiments showed that all four EuIII complexes displayed slow‐to‐intermediate water exchange kinetics. As expected, the CEST signals in these complexes decreased with increasing temperatures due to faster water exchange but, interestingly, the CEST signals for the C14 and C16 complexes approached a maximum near 25 °C consistent with exchange limited CEST at or near room temperature. The water residence lifetimes obtained by fitting the CEST spectra to the Bloch equations increased in parallel with an increase in alkyl carbon chain‐length. By comparisons with the monomethylamide complex, which served as control, the data illustrate that micelle formation serves to slow the rate of water exchange in these systems. The complex having the largest CEST effect per unit EuIII concentration (the C16 analog) had a detection limit of 5.3 μM. This represents an approximate 250‐fold increase in sensitivity relative to the monomethylamide control (detection limit ≈ 1.3 mM). These features highlight the potential of using micelle‐based systems such as these as paramagnetic chemical exchange saturation transfer (PARACEST) agents for molecular imaging by MRI.
Second primary lung cancer after head and neck squamous cell cancer: Population‐based study of risk factors
Authors: Milano Michael T. , Peterson Carl R. , Zhang Hong , Singh Deepinder P. , Chen Yuhchyau 
Published: February 2012

AbstractBackgroundPatients with head and neck squamous cell cancer (HNSCC) are at risk of developing second primary lung cancer (SPLC).MethodsAmong 61,883 patients with HNSCC from the Surveillance, Epidemiology and End Results (SEER) database, 4522 developed SPLC (any histology) ≥2 months after HNSCC. We correlated risk with demographic and tumor‐related parameters.ResultsThe risk of SPLC after HNSCC was 5.8%, 11.4%, and 16.4% at 5, 10, and 15 years, respectively. From Cox regression, significantly adverse (p < .0001) risk factors for SPLC included: regional versus localized HNSCC stage (hazard ratio [HR] = 1.16), hypopharyngeal or supraglottic laryngeal site (HR = 1.57), increased age (HR = 1.26/decade), black race (HR = 1.27), and male sex (HR = 1.26). Glottic (HR = 0.75) and tonsillar or oral cavity sites (HR = 0.80) were associated with significantly (p < .0001) lower risks of SPLC.ConclusionFrom population‐based actuarial analyses, HNSCCs with more aggressive clinicopathologic features were more apt to develop SPLC, suggestive of similar environmental and/or host factors for these cancers. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Net groundwater inflow in an enclosed lake: from synoptic variations to climatic projections
Authors: Kirillin G. , Phillip W. , Engelhardt C. , Nützmann G. 
Published: February 2012

AbstractUsing lake Stechlin in northeastern Germany as an example of a small groundwater‐feed lake without surface inflows and outflows, we estimated the temporal scales and the variability ranges of the net groundwater contribution to the lake water budget. High‐resolution water level measurements by a bottom‐mounted pressure logger provided the background for the estimation of the total lake water budget. This method has demonstrated reliability for estimation of lake level variations during periods ranging from subdiurnal to perennial. The typical amplitudes of the synoptic‐to‐perennial variability characterizing the groundwater climate of lake Stechlin are estimated by comparing the two subsequent years 2006 and 2007; one of these years shows an extremely high, and the other an extremely low, annual precipitation–evaporation balance. The net groundwater flow, estimated as the difference between the total water budget and the precipitation–evaporation balance at the surface, revealed synoptic effects of lake water exfiltration into the groundwater aquifer following strong precipitation events. Perennial variations between wet and dry years superimposed seasonal oscillations. The probable origin of the latter is seasonality in the groundwater level on the watershed, although the exact amplitudes are subject to further quantification on account of seasonality in the evaporation estimation error. The results emphasize the non‐stationary behaviour of groundwater flow on timescales shorter than climatic ones. The analysis yielded a net quantitative relationship between groundwater flow and water balance at the lake surface: The water level changes in the lake due to evaporation and precipitation are damped to 60% because of the lake–groundwater exchange by means of intermittent infiltration and exfiltration events. Assuming the remaining 40% of the surface water budget may potentially result in perennial water level variability, we estimated an effect of the precipitation decrease on the lake water budget as predicted by the regional climate scenarios for the next century. Copyright © 2012 John Wiley & Sons, Ltd.
Comparability of cancer identification among Death Registry, Cancer Registry and Hospital Discharge Registry
Authors: Ji Jianguang , Sundquist Kristina , Sundquist Jan , Hemminki Kari 
Published: February 2012

AbstractRegistry‐based cancer incidence and mortality data are widely used for etiologic research, cancer control and health care monitoring and planning. The complete coverage of all cases is the key criteria of data quality but it is difficult to assess because the alternative sources of data may be flawed. The aim of our study was to examine, at a nationwide level, the completeness of the Swedish Cancer Registry (CR) regarding persons who died of cancer, based on the Cause of Death Registry (DR), and using the Hospital Discharge Registry (HDR) as an additional source of data. Individuals who died of cancer from years 1999 through 2008 recorded in DR were linked to CR and HDR. A total of 190,692 individuals were identified from DR with cancer as the underlying cause of death; the mean identification rate of concordant cancer in CR was 79.8%, depending on tumor site and age at death. Breast, bladder and prostate cancers showed the highest rate of identification, whereas bone, liver and pancreatic cancers showed the lowest rate of identification. CR had no records on 10.6% of cancer cases recorded in DR. Similarly, the identification rate in HDR was 84.5% for concordant cancer and with 9.6% of cases missing. Neither source reported cancers for 3.4% of cancer cases recorded in DR. In conclusion, some 10% of cancer deaths had no cancer records in CR or in HDR, and 3.4% were missing in both sources. The identification rate depended on tumor site, age at death and, to some extent, death outside hospital.
How should individuals with a false‐positive fecal occult blood test for colorectal cancer be managed? A decision analysis
Authors: Haug Ulrike , Knudsen Amy B. , Kuntz Karen M. 
Published: February 2012

AbstractSeveral industrialized nations recommend fecal occult blood testing (FOBT) to screen for colorectal cancer (CRC), but corresponding screening guidelines do not specify how individuals with a prior false‐positive FOBT result (fpFOBT) should be managed in terms of subsequent CRC screening. Accordingly, we conducted a decision analysis to compare different strategies for managing such individuals. We used a previously developed CRC microsimulation model, SimCRC, to calculate life‐years and the lifetime number of colonoscopies (as a measure of required resources) for a cohort of 50‐year‐olds to whom FOBT‐based CRC screening is offered annually from 50 to 75 years. We compared three management strategies for individuals with a prior fpFOBT: (i) resume screening in 10 years with 10‐yearly colonoscopy (SwitchCol_long); (ii) resume screening in 1 year with annual FOBT (ContinueFOBT_Short) and (iii) resume screening in 10 years (i.e., the recommended interval following a negative colonscopy) with annual FOBT (ContinueFOBT_long). We performed sensitivity analyses on various parameters and assumptions. When using different management strategies for individuals with a prior fpFOBT, the variation in the number of life‐years gained relative to no screening was <2%, whereas the variation in the lifetime number of colonoscopies was 23% (percentages are calculated as the maximum difference across strategies divided by the lowest number across strategies). The ContinueFOBT_long strategy showed the lowest lifetime number of colonoscopies per life‐year gained even when key assumptions were varied. In conclusion, the ContinueFOBT_long strategy was advantageous regarding both clinical benefit and required resources. Specifying an appropriate management strategy for individuals with a prior fpFOBT may substantially reduce required resources within a FOBT‐based CRC screening program without limiting its effectiveness.
The association between two polymorphisms in the TS gene and risk of cancer: A systematic review and pooled analysis
Authors: Zhou Jue‐Yu , Shi Rong , Yu Hai‐Lang , Zeng Ye , Zheng Wen‐Ling , Ma Wen‐Li 
Published: February 2012

AbstractThymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of deoxyuridine monophosphate to deoxythymidine monophosphate, which is essential for DNA replication. Thymidylate synthase enhancer region (TSER) and TS1494del6, two functionally important and ethnically diverse polymorphisms mapping to its gene region, are the most extensively studied. Considering the potential influence of altering TS activity, it is plausible that TS polymorphisms might play a role in the development of cancer. Although the effects of TS polymorphisms on susceptibility to human cancer have been investigated in many studies, the results remain conflicting rather than conclusive. To resolve these conflicts, we performed a quantitative synthesis of the evidence on the association between these two polymorphisms and cancer risk, including 63 studies (19,707 cases and 27,398 controls) for TSER polymorphism and 39 studies (13,489 cases and 16,297 controls) for TS1494del6 polymorphism. Our meta‐analysis suggested that these two polymorphisms are not associated with cancer risk when all studies were pooled together. In the stratified analyses, we found that individuals with 2R/2R genotype had a significantly higher cancer risks among Asians (2R/2R vs. 3R/3R: odds ratio [OR] = 1.24, 95% confidence interval (95% CI) = 1.05–1.45; recessive model: OR = 1.23, 95% CI = 1.05–1.44). Further analyses revealed that 2R/2R genotype was significantly associated with an increased risk of gastroesophageal cancer among Asians, whereas it might provide protecting effects against colorectal cancer risk in a dominant genetic model for Caucasians. Additionally, TS1494del6 polymorphism may contribute to genetic susceptibility of breast cancer among Asians.