bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Mental Health Nurses' Perspectives on the Australian Stepped Care Model in Primary Mental Health Services
Authors: Mareya Shingai , Zhao Lin , Watts Mimmie Claudine , Olasoji Michael 
Published: February 2025

ABSTRACTPrimary healthcare remains an essential aspect of mental health service delivery in most developed nations worldwide. Mental health nurses (MHNs) play an important role in the delivery of mental health care within primary health care settings. This study, a subset of a broader study, explores MHNs’ experiences of the stepped care model (SCM) in Australian primary mental healthcare. Through semistructured interviews, the exploratory descriptive inquiry study explores the perspectives of eight MHNs on the implementation and effectiveness of the SCM across diverse settings, delving into their roles, motivations, approaches to care, experiences and the challenges encountered. Five themes were identified: the diverse roles of MHNs in the SCM, motivation to work in SCM, a consumer‐centred approach, challenges of the SCM and ‘it is great if you can get it’. Findings reveal diverse roles, from delivering psychotherapy to consumers presenting with mild to moderate needs to coordinating care for individuals presenting with severe and complex challenges. MHNs working in the SCM are driven by a desire to provide flexible, recovery‐focused care. They prioritise consumer‐centred approaches and tailored care to meet individual needs. They experience challenges, including professional isolation in some cases, resource constraints, limited session availability for the consumers they work with and administrative burdens. The study underscores the need for structural enhancements to optimise the SCM's effectiveness and meet diverse consumer needs. These insights from MHNs are relevant to policymakers, Primary Health Networks (PHNs), service providers and clinicians. Future research could expand the scope to include perspectives from various disciplines involved in the model, as well as consumers and carers accessing SCM services. Overall, this paper contributes valuable insights to the discourse on the effectiveness of the SCM through the lens of MHNs delivering care within the model.
Transforming Alcohol and Other Drug Education Through Co‐Design
Authors: Goodhew Mark , Matiuk Sonia , Axisa Carmen , Gough Chris , River Jo 
Published: February 2025

ABSTRACTOver the past decade, as a broader push to address community needs and improve health outcomes, socially marginalised people have become increasingly involved in co‐design research and education. More recently, people with lived experience of substance dependence have co‐designed and co‐delivered Alcohol and Other Drugs (AOD) education with nurse educators. Evaluations of co‐designed AOD education have largely focused on educational and clinical outcomes but not on the process of co‐design. Because of this gap, there is a need for research that explores the process of undertaking co‐design with people who use substances and clinicians, including facilitators and barriers to the process that are specific to these groups. This research reports on a qualitative study exploring the barriers, facilitators, and perceived value of a co‐design process for an AOD clinical education program involving people with lived experience of substance use, nurse clinicians, and academics (nursing and public health). The participants reported that building trusting relationships and skilled facilitation enhanced the co‐design process, enabling positive conditions for working in partnership to achieve the project outcomes. However, challenging interpersonal dynamics, lack of adequate resources, and overly directive facilitation could impact team dynamics and undermine the co‐design process. Authentic co‐design has the potential to transform AOD education, ensuring that it centres the needs of people with lived experience. However, co‐design initiatives require adequate resourcing and time to develop equal and respectful relationships for this vision to be realised.
Inventor‐base concentration and corporate cash holdings
Authors: Wang Jin 
Published: February 2025

AbstractUsing a unique dataset tracking the career paths of inventors in U.S. public firms, we investigate how inventor‐base concentration impacts corporate cash holdings. A concentrated inventor base enhances the efficiency of utilizing inventors' human capital, reducing the transaction motive to hold cash. Conversely, the potential loss due to key inventors' departure may increase the precautionary motive to hold cash. We find a negative impact of inventor‐base concentration on cash holdings, supporting the notion of reducing the transaction motive. Firms with a more concentrated inventor base have lower demand for spending cash on labor costs and R&D. Additionally, the negative impact on cash holdings is more pronounced for firms facing financial constraints. Finally, the value of cash holdings is negatively related to the degree of inventor‐base concentration. These results highlight the importance of understanding a firm's human capital strategies when evaluating its financing policy.
Inclusion of Autistic IT Workforce in Action: An Auticon Approach
Authors: Abramova Olga , Recker Jan , Schemm Ursula , Barwitzki Lukas‐Daniel 
Published: February 2025

ABSTRACTThis paper examines the IT workforce management practices of auticon, a pioneering international IT consultancy firm from Germany that employs autistic individuals as its core workforce to deliver economically and socially sustainable IT services. Our analysis of auticon's approach allows us to distil four key workplace inclusion lessons for companies on how to best integrate neurodivergent professionals in the workplace and three lessons relevant to the IT industry on its journey to become more equitable and inclusive.
Inhibitory effect of nitrite on iron sulfide dissolution at high pH
Authors: Li Zhanzhao , Hunt Angelica , Kaladharan Gopakumar , Shallenberger Jeffrey R. , Gorski Christopher A. , Radlińska Aleksandra 
Published: February 2025

AbstractOxidation reactions of iron sulfide‐bearing aggregates have been increasingly recognized as a significant cause of concrete deterioration worldwide. Yet there is a lack of mitigation strategies to control the reactions. This work investigates the effectiveness of nitrate‐ and nitrite‐based admixtures in inhibiting the dissolution of iron sulfides (pyrrhotite and pyrite) in highly alkaline environments, the first step of the deleterious reactions in concrete. Although the addition of nitrate was not found to exhibit a profound influence, the use of nitrite significantly slowed down the dissolution, reducing the overall dissolution extent by nearly 90%. Solid characterization indicated that nitrite may accelerate the formation of a protective passive layer that acts as a diffusion barrier and inhibits further dissolution. The findings demonstrate the potential of nitrite as an inhibiting admixture for controlling iron sulfide dissolution, offering new avenues for developing practical mitigation strategies for related deterioration in concrete.
Enhancing dielectric properties of BaZrTiO3 via controlled anatase/rutile core‐shell TiO2
Authors: Nam Wolil , Cheon Ransae , Seo Jihye , Heo Seokha , Cho Seungchan , Byun Giyoung , Kim Yangdo , Choi Moonhee 
Published: February 2025

AbstractNumerous studies are being conducted to develop novel materials capable of achieving ultrahigh dielectric constants. In this research, we focused on controlling oxygen vacancies and grain growth in dielectric materials to enhance their dielectric properties. To achieve this, we successfully manipulated the crystal structure of TiO2 in the perovskite structure using a core‐shell approach. This innovative method allowed us, for the first time, to regulate both oxygen vacancies and grain growth during solid‐state synthesis. After heat‐treating metastable anatase TiO2 to form an anatase/rutile core‐shell structure, it was used as a precursor for Ba–Zr–TiO3 solid‐state synthesis. At the optimal conditions for the anatase/rutile core‐shell (87% rutile and 13% anatase), the electron excitation in TiO2 between the stable phase (rutile) and the metastable phase (anatase) generates localized Ti3+. The resulting oxygen vacancies induce the formation of electron‐pinned defect clusters, which are a significant cause of the ultrahigh dielectric constant in barium zirconate titanate.
Assessing the Impact of an Integrated Community Care Program on Unplanned Hospital and Emergency Department Representations: Interrupted Time Series Analysis
Authors: Shannon Brendan , Collyer Taya , Bowles Kelly‐Ann , Williams Cylie , Ravipati Tanya , Deighton Elise , Andrew Nadine E. 
Published: February 2025

ABSTRACTBackgroundThis study aimed to evaluate the impact of the Community Care Program, which was the amalgamation of three outreach services—post‐acute care, Residential In‐Reach, and the Hospital Admission Risk Program—into a single integrated care model. Specifically, we assessed its effects on unplanned hospital readmissions and emergency department re‐presentations at 30‐, 60‐ and 90‐days post‐enrolment.MethodsA pragmatic, real‐world, population‐based observational study was conducted using an interrupted time series analysis. The study included 4708 adult patients across two periods: pre‐amalgamation (November 2014–October 2016), and post‐amalgamation (May 2017–October 2018). Data were sourced from the National Centre for Healthy Ageing Data Platform, with statistical analyses conducted using Generalised Least Squares models to account for autocorrelation.ResultsThe study observed a significant increase in quarterly program enrolments post‐amalgamation, from 578 to 1011 per quarter. The 30‐day readmission rate decreased from 11.8% to 8.52% post‐amalgamation. However, interrupted time series analysis revealed no statistically significant changes in the slopes of readmission and emergency department re‐presentation rates after the program's amalgamation. The program did not result in significant changes in 60‐ or 90‐day outcomes.ConclusionsThe amalgamation of post‐acute care, Residential In‐Reach, and the Hospital Admission Risk Program into the Community Care Program led to increased service utilisation without a significant impact on reducing unplanned hospital readmissions or emergency department re‐presentations. Although the program amalgamation demonstrated improved accessibility, its longer‐term impact remains inconclusive, highlighting the need for continuous refinement and further evaluation to optimise system efficiency. No patient or public contribution occurred in this study.Reporting MethodThis study adhered to the STROBE guidelines for observational research.
Press Freedom and Systemic Risk
Authors: Kladakis George , Skouralis Alexandros 
Published: February 2025

ABSTRACTThis paper investigates the role of press freedom on systemic risk using an international sample of banks. We construct a novel and comprehensive measure of press freedom by integrating data from multiple widely recognized sources: the Reporters Without Borders Press Freedom country ranking, the Freedom of Expression Index, and the Freedom House Index. By combining these three distinct indices, our measure offers a more robust and multi‐dimensional assessment of press freedom, capturing a broader spectrum of factors influencing media independence and freedom of expression across countries. Our empirical evidence suggests that press freedom is associated with lower systemic risk in the banking sector. We show that this relationship is mitigated during the upward phase of the economic cycle, and enhanced during banking crises. Our findings hold when addressing potential endogeneity problems and when accounting for additional macroeconomic and firm controls.
Contemporary Study of New Onset Atrial Fibrillation Treatment Strategies at a Large Academic Tertiary Care Center
Authors: Zghaib Tarek , Khoshknab Mirmilad , Markman Timothy M. , Marchlinski Francis E. , Epstein Andrew E. , Nazarian Saman 
Published: February 2025

ABSTRACTBackgroundEarly rhythm‐control after atrial fibrillation (AF) incidence is associated with improved cardiovascular outcomes. Moreover, AF ablation provides more effective rhythm‐control than antiarrhythmic drugs (AADs). The extent of adoption of contemporary trials and guidelines for the management of new onset AF is unknown.ObjectiveIn this observational retrospective study, we sought to evaluate treatment pathways for new onset AF at a large tertiary academic medical center within the last 6 years.MethodsWe performed a systematic search within our institutional TriNetX database to identify adult patients who (1) had new onset AF between January 2018 and January 2023, (2) did not have surgery or thyrotoxicosis within 1 month of incident AF diagnosis, and (3) had at least one visit at our center > 6 months after initial AF diagnosis. Patients with prior AF diagnosis were excluded. We identified the initial three lines of treatment administered following AF diagnosis, including rate‐ or rhythm‐control strategies with AADs or ablation therapy.ResultsThe cohort included 24 990 patients (mean age at diagnosis 69.8 ± 13.1 years, 58% male). During follow‐up, 7130 (29%) received rhythm‐control, 9760 (39%) received rate‐control, and 8100 (32%) received neither. Rhythm‐control consisted of AADs in 4610 (18%) and AF ablation in 2530 (10%). As first line therapy, 12 055 (48%) patients received rate‐control, 3919 (16%) received AADs and 916 (4%) underwent AF ablation.ConclusionMost contemporary patients with incident AF at a large US academic tertiary center either received no rate or rhythm intervention or only rate‐control.
Iloprost Concentration‐Dependently Attenuates Platelet Function and Apoptosis by Elevating PKA Activity
Authors: Wang Xuexiang , Chen Shuang , Wan Jun , Liu Chunliang , Yan Yan , Khan Muhammad Shoaib , Zhao Ziyu , Sun Kang , Hu Renping , Yang Mengnan , Xia Yue , Dai Kesheng 
Published: February 2025

ABSTRACTIloprost, a prostacyclin (PGI2) analogue, stimulates the IP receptor (PTGIR) to interact with the Gsα β/γ complex, leading to the activation of adenylate cyclase, which enzyme produces the second messenger cAMP. Elevation in cAMP triggers intracellular signalling events and regulates a wide variety of cellular activities. Thus, we evaluated the effects of Iloprost on platelet function and apoptosis and in vivo haemostasis and thrombosis, as well as the underlying mechanisms. Firstly, we showed that Iloprost concentration‐dependently inhibited agonist‐induced P‐selectin exposure, integrin αIIbβ3 activation, platelet aggregation, ATP release, platelet spreading, and clot retraction. Moreover, Iloprost dose‐dependently inhibited FeCl3‐induced mouse mesenteric arteriole thrombosis and markedly prolonged the tail bleeding time. Iloprost also concentration‐dependently inhibited mitochondrial membrane potential (ΔΨm) depolarisation and phosphatidylserine (PS) externalisation in platelets, thereby inhibiting platelet apoptosis, and Iloprost at concentrations lower than 2 nM inhibited only platelet apoptosis but not platelet function. Importantly, Iloprost at low doses markedly elevated peripheral platelet counts in GPIbα antibody‐induced immune thrombocytopenia (ITP). Mechanistic studies showed that Iloprost concentration‐dependently antagonised agonist‐induced decline of protein kinase A (PKA) activity and elevation of cytoplasmic Ca2+ in platelets, thereby attenuating platelet activation and aggregation. Elevation in PKA activity inhibited dephosphorylation of proapoptotic protein BAD and reduced caspase‐3 activity, thus retarding platelet apoptosis. These data demonstrate that Iloprost dose‐dependently inhibits platelet function and apoptosis by elevating PKA activity. Moderate‐dose Iloprost impairs haemostasis and thrombosis via suppression of platelet function, and low‐dose Iloprost elevates peripheral platelet levels by inhibiting platelet apoptosis while having no effects on platelet function.
Application of Conservation Strategies for Bacteriophages Used in the Biocontrol of Pathogenic Microorganisms in Food
Authors: Hernández‐Arteaga Ana María , Mendoza‐Corvis Fernando , Salgado‐Behaine Jose , Gontijo Marco , Batalha Laís Silva , Perez Genesy , Sierra Omar Perez , Soto Lopez Maryoris E. 
Published: February 2025

ABSTRACTThe encapsulation of bacteriophages shows significant potential as a biocontrol strategy in the food industry. This review explores diverse strategies, including freeze‐drying, spray‐drying, and extrusion dripping, along with the macromolecular matrices used to stabilize bacteriophages. Key findings are highlighted in the control of foodborne pathogens such as Staphylococcus aureus, Escherichia coli, Salmonella spp., and Pseudomonas spp. Among the encapsulating agents, polymers, particularly alginate, stand out due to their biocompatibility, gel‐forming properties, ease of use, and capacity for controlled release. Different techniques and matrices have demonstrated the ability to preserve dry phage powders for up to 27 months with minimal reduction in phage titer. However, encapsulation efficiency depends on factors such as bacteriophage type, encapsulant concentration, encapsulant type, and process parameters. The development of tailored bacteriophage encapsulation strategies holds promise for expanding agricultural and food applications of bacteriophage technology.
Expert Opinions on an Optimal Infant Feeding Quantitative Data Framework: A Mixed Methods Delphi‐Style Study in the UK
Authors: Embling Rochelle , Evans Rachel , Mchugh Niamh , Kolosowska Anna , Nagaraj Varsha , Bath Rachel 
Published: February 2025

ABSTRACTBackgroundThis study aimed to explore how expert stakeholders involved in research, policy and practice would define an ideal dataset for collecting infant feeding data, to better align efforts to monitor and evaluate breastfeeding across the UK four nations.MethodologyUsing the Delphi method, two phases of consultation were completed with a total of 42 stakeholders. First, qualitative (Round 1) and quantitative (Round 2) surveys were distributed to an interdisciplinary panel of experts, to identify individual‐level agreement for key terms and timepoints for data collection relevant to infant age. Second, policy‐led stakeholders discussed outcomes from Phase 1, before contributing to a written consultation response for their nation to indicate group‐level agreement.ResultsAcross Phase 1 surveys, 13 of 15 indicators reached consensus for definitions, and 11 of 13 reached consensus for timepoints. During Phase 2, 5 of 7 indicators reached a level of final agreement. Data collection was suggested to focus on the intention to breastfeed (around birth), and the early initiation of feeding (from birth to 10 days). Monitoring of ‘exclusive’ breastfeeding from 0 to 6 months, ‘any’ breastfeeding from 0 to 24 months, and complementary feeding at 6 and 12 months, were identified as key touchpoints.Principal ConclusionsTo support the feasibility of data reforms across UK nations, these results identify consensus for a shortlist of shared data indicators (see Supplementary Figure 1), highlighting opportunities for data collection that close the gap with international standards, and align with existing monitoring frameworks and healthcare practice.
mTORC2 Regulates Actin Polymerization in Auditory Cells
Authors: Lanz Michael , Cortada Maurizio , Lu Yu , Levano Soledad , Bodmer Daniel 
Published: February 2025

ABSTRACTMammalian target of rapamycin complex 2 (mTORC2) is essential for hearing by regulating auditory hair cell structure and function. However, mechanistic details of how mTORC2 regulates intracellular processes in sensory hair cells have not yet been clarified. To further elucidate the role of mTORC2 in auditory cells, we generated a Rictor knockout cell line from HEI‐OC1 auditory cells. mTORC2‐deficient auditory cells exhibited significant alterations in actin cytoskeleton morphology and decreased proliferation rates. Additionally, we observed a reduction in phosphorylation of protein kinase C alpha (PKCα) and disrupted actin polymerization in mTORC2‐deficient cells. Using proteomics, we found that mTORC2 disruption altered expression of cytoskeleton‐related proteins in auditory cells. These findings provide valuable mechanistic insights into the functional role of mTORC2 in auditory cells, potentially opening new perspectives to address sensorineural hearing loss.image
Prenatal Alcohol Consumption Alters Protein Fingerprint in Umbilical Cord Blood Serum and Induces Brain Microvascular Endothelial Cell Dysfunction
Authors: Almeida Paula Silva Lacerda , Araújo Dayana , Nascimento Juliana Minardi , Manhães Alex C. , Jesus Nilson Ramires , Stipursky Joice 
Published: February 2025

ABSTRACTConsumption of alcoholic beverages during pregnancy is directly related to the establishment of fetal alcohol spectrum disorders (FASD), which includes craniofacial changes, body growth restriction, and neurodevelopment impairments. Proper functioning of the central nervous system (CNS) depends on blood–brain barrier (BBB) development, which is formed by interactions of vascular endothelial cells, pericytes, astrocytes, and basal lamina. Gestational exposure to ethanol has been demonstrated to impair CNS development; however, little is known about ethanol modulation of blood circulating factors and impacts on human developing BBB. Here we investigated the prevalence of alcohol consumption during pregnancy and found that 27% of pregnant women reported alcohol consumption, mainly in the first trimester. Control and alcohol‐exposed newborns showed no differences in weight, length, and appearance, pulse, grimace, activity, respiration (APGAR) score at birth. In vitro, we cultivated human brain microcapillary endothelial cells (HBMEC) and treated with umbilical cord blood serum (UCBS) from control (S‐Control) newborns or ethanol‐exposed ones (S‐Ethanol). S‐Ethanol treatment induced 68% and 38% decreases in protein levels of ZO‐1 (tight junction) and GLUT‐1 (glucose transporter type‐1), respectively, increased endothelial monolayer permeability, migratory potential impairment, and changes in angiogenesis‐related secreted proteins profile, compared to S‐Control treatments. UCBS proteomics revealed a total of 392 proteins, 10 exclusively found in S‐Ethanol, mostly related to innate and adaptive immunity and tissue injury response. These results suggest that gestational exposure to ethanol contributes to blood altered protein profiles triggering BBB endothelial.image