bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunological aspects of fresh‐frozen allogeneic bone grafting for lateral ridge augmentation
Authors: Spin‐Neto Rubens , Stavropoulos Andreas , de Freitas Rubens Moreno , Pereira Luís Antônio Violin Dias , Carlos Iracilda Zeppone , Marcantonio Elcio 
Published: June 2012

AbstractObjectivesTo present some immunological aspects of fresh‐frozen allogeneic bone grafting for lateral bone augmentation, based on the quantitative evaluation of IL‐10, IL‐1β, IFN‐ γ and TNF‐ α in patients sera.Material and methodsThirty‐three partially or totally edentulous patients received fresh‐frozen allogeneic bone (AL – 20 patients) or autologous bone onlay block grafts (AT – 13 patients) prior to oral implant placement. Blood samples were collected from each patient at various time‐points during a 6 month‐period (baseline, 14, 30, 90 and 180 days postoperatively). Quantitative evaluation of IL‐10, IL‐1β, IFN‐ γ and TNF‐ α was performed by enzyme linked immunosorbent assay (ELISA).ResultsFor all evaluated markers and at all evaluated periods, inter‐group comparisons showed no statistically significant differences between the groups, while the observed values were within normal levels. For AL‐treated patients, intra‐group evaluation showed statistically significant increase of TNF‐α from baseline to 90 (P < 0.001) and 180 (P < 0.01) days, and from 14 to 90 (P < 0.01) and 180 (P < 0.05) days. IFN‐ γ showed intercalated results, with a decrease from baseline to 14 days (P < 0.05), and increase from 14 to 90 days (P < 0.001) and 180 (P < 0.05) days. No differences between the periods of evaluation were found for the AT group.Conclusions
AL grafting for lateral bone augmentation, similar to AT grafting, does not seem to challenge the immune system significantly.
Long‐term outcome of implants placed with guided bone regeneration (GBR) using resorbable and non‐resorbable membranes after 12–14 years
Authors: Jung Ronald E. , Fenner Nadine , Hämmerle Christoph H. F. , Zitzmann Nicola U. 
Published: June 2012

AbstractAimThe aim of the present prospective study was to evaluate the long‐term outcome of implants placed simultaneously with guided bone regeneration (GBR) using resorbable and non‐resorbable membranes.Materials and methodsThe original study population consisted of 72 patients receiving a total of 265 implants. In all GBR‐treated sites, demineralized bovine bone mineral (DBBM) was used in combination either with a collagen (CM) or an Expanded polytetrafluoroethylene (e‐PTFE) membrane. A total of 112 implants was treated with CM, 41 implants were treated with e‐PTFE membranes, and 112 served as a control group because implants were entirely surrounded by bone and did not need any GBR procedures. Clinical and radiographic analyses were performed after a period of 12–14 years.ResultsThe median follow‐up time was 12.5 years (range 12–14 years). A total of 58 patients participated in the present investigation, corresponding to 80.5% of the original study population. The cumulative implant survival rate at the follow‐up examination was 93.2%. For the control group the cumulative survival rate was 94.6%, for the CM 91.9%, and for the e‐PTFE 92.6%. Differences among the groups were not statistically significant.The radiographically determined marginal bone level (MBL) amounted to: control 2.36 mm (SD), CM 2.4 mm (SD), e‐PTFE 2.53 mm (SD). There is no evidence (P < 0.2) that the slope of bone level over time is different for the three treatment groups.ConclusionIt is concluded that implants placed simultaneously with GBR procedures using resorbable or non‐resorbable membranes reveal a high survival rate ranging from 91.9% to 92.6%, therefore it is considered to be a safe and predictable therapy. [Correction added after online publication 30 November 2012: the marginal bone level of CM, e‐PTFE, and control was corrected to ‘control 2.36 mm (SD), CM 2.4 mm (SD), e‐PTFE 2.53 mm (SD)’ in the Results section]
Atypical fibroxanthoma
Authors: Ziemer Mirjana 
Published: June 2012

SummaryAtypical fibroxanthoma (AFX) is a rare neoplastic disease of the skin. Since the term was coined in the early 1960s, the disease has been viewed in many ways. For a long time AFX was regarded as a superficial variant of malignant fibrous histiocytoma (MFH). When the concept of MFH was re‐evaluated and the term “undifferentiated pleomorphic sarcoma” (UPS) introduced, the controversy about the nature of AFX increased. The following review aims at providing an understanding of the present status of diagnosis and therapy of AFX based on the historical context and current data.
A Systematic Review of the Evidence: The Effects of Portion Size Manipulation with Children and Portion Education/Training Interventions on Dietary Intake with Adults
Authors: Small Leigh , Lane Heather , Vaughan Linda , Melnyk Bernadette , McBurnett Danielle 
Published: June 2012

ABSTRACTBackgroundEvidence shows that 3–5‐year‐old children undergo important physical and behavioral changes that include being affected by the amount of food they are served, with larger portions of food served resulting in greater dietary intake. This may be a key finding as researchers continue to identify effective treatments for the growing number of preschool children who are overweight or obese. Knowledge of the effects of varying portion sizes on young children's dietary intake is important; however, because parents of young children control the manner in which children are fed, educating parents regarding the estimation of portion sizes is an approach worth exploring as a way to affect the trajectory of their young child's weight gain.AimsThe purposes of this systematic review were to determine (1) findings regarding the effect of varying portion sizes with young children and (2) the evidence regarding the effects of educating adults to estimate portion sizes. Evidence from this review may guide clinical practice and future research efforts.MethodsA comprehensive literature search was conducted with multiple databases using MeSH Headings and keywords. This search strategy was supplemented by ancestry searches of all relevant articles. Two independent, trained pediatric practitioners determined quality of the studies using established criteria.ResultsNine studies met the inclusion criteria as portion‐manipulation interventions or portion‐education/training interventions and were appraised. Evidence showed the positive effect of portion sizes on the energy intake of children. In addition, the ability of adults to accurately estimate portion size improved following education/training.ConclusionsAlthough many studies have focused on a variety of portion‐related interventions, the influence of portion education with parents of young children has not been well researched. More research is needed to understand the effect of parent‐focused, portion‐education interventions that encourage appropriate energy intake and healthy weight attainment in young children.
From steady‐state to synchronized yeast glycolytic oscillations I: model construction
Authors: du Preez Franco B. , van Niekerk David D. , Kooi Bob , Rohwer Johann M. , Snoep Jacky L. 
Published: June 2012

An existing detailed kinetic model for the steady‐state behavior of yeast glycolysis was tested for its ability to simulate dynamic behavior. Using a small subset of experimental data, the original model was adapted by adjusting its parameter values in three optimization steps. Only small adaptations to the original model were required for realistic simulation of experimental data for limit‐cycle oscillations. The greatest changes were required for parameter values for the phosphofructokinase reaction. The importance of ATP for the oscillatory mechanism and NAD(H) for inter‐and intra‐cellular communications and synchronization was evident in the optimization steps and simulation experiments. In an accompanying paper [du Preez F et al. (2012) FEBS J279, 2823–2836], we validate the model for a wide variety of experiments on oscillatory yeast cells. The results are important for re‐use of detailed kinetic models in modular modeling approaches and for approaches such as that used in the Silicon Cell initiative.Database
The mathematical models described here have been submitted to the JWS Online Cellular Systems Modelling Database and can be accessed at http://jjj.biochem.sun.ac.za/database/dupreez/index.html.
Development of secondary skull sarcoma after treatment for childhood acute myeloid leukemia
Authors: Ohno Makoto , Narita Yoshitaka , Miyakita Yasuji , Okita Yoshiko , Kayama Takamasa , Shibui Soichiro 
Published: June 2012

AbstractSecondary cancer is a serious late complication in childhood leukemia survivors. Here, we report a case of secondary skull sarcoma developing after treatment for childhood acute myeloid leukemia, including bone marrow transplantation (BMT). This patient had breast cancer 1 year before treatment for the skull sarcoma. The patient underwent macroscopic total removal of the skull tumor with bone margin with postoperative radiation therapy and did not develop tumor recurrence for 25 months. Our patient's experience suggests that survivors of childhood leukemia are at risk of developing skull sarcoma and that multi‐agent chemotherapy, including anthracycline, TBI used as conditioning for BMT, and development of GVHD, are possible risk factors. Considering the possibility of multiple secondary malignancies in such patients, careful long‐term follow up is mandatory.
Interaction between risk factors for iron deficiency in young children
Authors: BRUNT Deborah R. , GRANT Cameron C. , WALL Clare R. , REED Peter W. 
Published: June 2012

AbstractAims:  To describe interactions between risk factors for iron deficiency (ID).Methods:  A random community sample of 316 children 6–23 months old of whom 13% had ID. Risk factors for ID were determined using logistic regression. Relative risks (RR) and 95% confidence intervals (95%CIs) were estimated. An additive relationship between risk factors was present if the RR of ID when both factors were present exceeded the sum of individual RRs of ID.Results:  Independent risk factors for ID in a multivariate model were prematurity/low birthweight (RR 4.82, 95%CI 1.57–7.42), increased body mass index (5.57, 1.41–12.18), eating fruit only as a snack (3.48, 1.38–7.28), having no milk formula (4.40, 2.06–7.27), daily cow's milk (4.71, 1.99–8.56) and having only homemade first solids (2.91, 1.01–6.40). Eating fruit only as a snack had an additive relationship with three other dietary risk factors: no milk formula (RR 11.75, 95%CI 4.58–19.46), cow's milk daily (13.48, 1.20–42.37) and only homemade first solids (8.66, 3.43–14.76). Larger body mass had an additive relationship with four dietary factors: no milk formula (RR 14.69, 95%CI 1.95–24.00), fruit only as a snack (10.11, 4.59–16.36), cow's milk daily (12.28, 5.97–21.95) and only homemade first solids (7.05, 1.27–16.27). Prematurity/low birthweight had an additive relationship with two dietary risk factors: no milk formula (RR 9.16, 95%CI 2.42–12.11) and only homemade first solids (7.15, 1.47–9.73).Conclusions:  Risk factors for ID interact to place young children at high risk of ID.
Higher unprocessed red meat, chicken and fish intake is associated with a higher vegetable intake in mid‐age non‐vegetarian women
Authors: JENKINS Laura , MCEVOY Mark , PATTERSON Amanda , SIBBRITT David 
Published: June 2012

AbstractAim:  To investigate whether higher intakes of unprocessed red meat, chicken and fish are associated with higher intakes of vegetables in middle‐aged, non‐vegetarian Australian women.Methods:  Food intake data was collected from a nationally representative sample of 10 530 middle‐aged Australian women (50–55 years) who completed the third survey of the Australian Longitudinal Study on Women's Health. The validated Dietary Questionnaire for Epidemiological Studies (Version 2) was used. Multivariate regression analyses were used to determine the association between vegetable intake and four variables: total meat, red meat, chicken and fish intake in grams per day.Results:  Total meat (regression coefficient (RC) = 0.32, 95% CI: 0.30–0.34; P < 0.001), red meat (RC = 0.45, 95% CI: 0.42–0.48; P < 0.001), chicken (RC = 0.78, 95% CI: 0.70–0.85; P < 0.001) and fish intake (RC = 0.48, 95% CI: 0.42–0.53; P < 0.001) were significantly associated with higher vegetable intakes after adjusting for confounders. The adjusted R2 values for each of the regression models were relatively small (0.1590, 0.1394, 0.0932, 0.0802), indicating that the included predictors did not account for much of the variation in vegetable intake.Conclusion:  These results provide some evidence that higher intakes of unprocessed red meat, chicken and fish are associated with higher intakes of vegetables. This supports the notion that many Australians who are serving up unprocessed red meat, chicken or fish for their meals are also consuming a number of vegetable serves.
Australian children's food and drink preferences: Implications for health professionals
Authors: PESCUD Melanie , PETTIGREW Simone , DONOVAN Robert J. , COWIE Samantha , FIELDER Lynda 
Published: June 2012

AbstractAim:  Children's food and drink preferences play an important role in determining their consumption behaviours, but data pertaining to Australian children's preferences are lacking. The present study investigated children's preferences and health practitioners' assumptions relating to these preferences.Methods:  Five hundred and twenty‐four Australian primary schoolchildren completed a written survey to explore their food and drink preferences and 576 health professionals (HPs) participated in an online survey to identify their perceptions of children's preferences. The traffic light system of food classification was used to determine the healthiness of the foods and drinks nominated as favourites by children and HPs. Data were analysed using chi‐square tests to assess the extent to which children's and HPs' responses differed. Differences according to socio‐demographic variables were investigated.Results:  Children's reported preferences were healthier than HPs expected. Younger children had healthier preferences than their older peers, and girls chose healthier items than boys. Children from the medium socioeconomic schools preferred healthier foods compared with their low socioeconomic peers, but low socioeconomic children preferred healthier drinks compared to medium socioeconomic children. There were no differences between the HPs' results according to demographic variables.Conclusions:  Given that children are reporting preferences for healthy options yet intakes of healthy foods are suboptimal among Australian children, efforts to improve the health status of Australian children should include strategies to encourage adults to make healthy foods and drinks more available and accessible.
Wooden Legs and Tales of Sorrow Done: The Literary Broken Soldier of the Late Eighteenth Century
Authors: PARKES SIMON 
Published: June 2012

AbstractThe literary character of the Broken Soldier is a cathartic presence in much eighteenth‐century writing. In works by authors such as Oliver Goldsmith, Henry Mackenzie and Robert Bage we find the figure of the Broken Soldier as the smashed recipient of society's self‐conscious benevolence. He is a sacrificial figure deflecting the realities of conflict and violence from the home front via his play‐acting and sanctioned tales. The horrors of war that seep back into society are diffused by encounters with the Broken Soldier, allowing echoes of violence to be contained within these literary texts and broken bodies.
Small Bowel Crohn's disease MRI pictorial essay
Authors: Lui Belinda , Sutherland Tom , Lasocki Arian , Hennessy Oliver 
Published: June 2012

SUMMARYThe focus of this article includes
Revision of normal small bowel anatomy on sequences performed at our institution, with advantages and disadvantages.
Brief summary of the disease.
Appearance of acute active disease.
Usefulness of ancillary findings of active disease.
Appearance of chronic disease both active and inactive.
Complications of Crohn's disease.
Pitfalls and limitations of interpretation.
Clinically relevant reporting through clinician feedback.
Bevacizumab modulates epithelial‐to‐mesenchymal transition in the retinal pigment epithelial cells via connective tissue growth factor up‐regulation
Authors: Chen Ching‐Long , Liang Chang‐Min , Chen Yi‐Hao , Tai Ming‐Cheng , Lu Da‐Wen , Chen Jiann‐Torng 
Published: June 2012

Abstract.Purpose:  To investigate the effect of bevacizumab treatment on connective tissue growth factor (CTGF) expression and the induction of epithelial‐to‐mesenchymal transition in ARPE‐19 cells and human donor retinal pigment epithelium (HRPE) cells in vitro.Methods:  We quantitated the protein and gene expression level of CTGF by ELISA. The effect of Fc–Fc receptor (Fc–FcR) interaction on CTGF expression was evaluated by CD64 siRNA silencing. Expression of epithelial‐to‐mesenchymal transition markers, alpha‐smooth muscle actin (α‐SMA) and zona occludens protein (ZO‐1) was evaluated by Western blot. Cell migration and collagen gel contraction assay were examined by light microscopy, and collagen production was measured by ELISA.Results:  Bevacizumab stimulation increased CTGF expression in ARPE‐19 and HRPE cells in a dose‐dependent manner. CD64 gene silencing inhibited the effect of bevacizumab‐induced CTGF up‐regulation. Bevacizumab increased the expression of α‐SMA and decreased the expression of ZO‐1 in ARPE‐19 cells. Bevacizumab also caused the release of type‐1 collagen and increased cell migration and contraction of collagen.Conclusions:  Bevacizumab exerts pro‐fibrotic effects on human RPE cells at clinical doses by up‐regulation of CTGF expression via an Fc–FcR interaction. This effect of bevacizumab may be one of the underlying mechanisms involved in age‐related macular degeneration therapy or intravitreal bevacizumab‐associated complications.
Measures in rheumatoid arthritis: are we measuring too many parameters
Authors: Chandrashekara S. , Sachin S. 
Published: June 2012

AbstractThe disease activity measures in rheumatoid arthritis (RA) have a lot of unmet need for current clinical demand. With available biological and aggressive disease modifying anti‐rheumatic drug therapy, the goal of RA treatment has moved toward remission or at least tighter control. The current measures lose their ability to discriminate further once the patient gets into minimal disease or tight control. There are more numbers of parameters, measured to assess disease activity, like joint counts, perception scales and laboratory parameters. There are different composite scores like Disease Activity Score, American College of Rheumatology criteria and clinical disease activity index. In this review we have reviewed the evolution of and changing need for these measures. The relevance of some measures and their use and limitations with reference to various characteristics are presented. Inflammation measures to quantify the RA process is the best way to monitor RA disease activity. C‐reactive protein alone or with other biomarkers to specify RA, appear to be good prospective measures.
Concurrent 2009 Pandemic Influenza A (H1N1) Virus Infection in Ferrets and in a Community in Pennsylvania
Authors: Campagnolo E. R. , Moll M. E. , Tuhacek K. , Simeone A. J. , Miller W. S. , Waller K. O. , Simwale O. , Rankin J. T. , Ostroff S. M. 
Published: June 2012

SummaryWe report a fall 2010 cluster of pandemic influenza A/H1N1 (pH1N1) infections in pet ferrets in Lehigh Valley region of Pennsylvania. The ferrets were associated with one pet shop. The influenza cluster occurred during a period when the existing human surveillance systems had identified little to no pH1N1 in humans in the Lehigh Valley, and there were no routine influenza surveillance systems for exotic pets. The index case was a 2.5‐month‐old neutered male ferret that was presented to a veterinary clinic with severe influenza‐like illness (ILI). In response to laboratory notification of a positive influenza test result, and upon request from the Pennsylvania Department of Health (PADOH), the Pennsylvania Department of Agriculture (PDA) conducted an investigation to identify other ill ferrets and to identify the source and extent of infection. PDA notified the PADOH of the pH1N1 infection in the ferrets, leading to enhanced human surveillance and the detection of pH1N1 human infections in the surrounding community. Five additional ferrets with ILI linked to the pet shop were identified. This simultaneous outbreak of ferret and human pH1N1 demonstrates the important link between animal health and public health and highlights the potential use of veterinary clinics for sentinel surveillance of diseases shared between animals and humans.
Meteoritic Iron Phosphide
Authors: Buddhue John Davis 
Published: June 2012

AbstractThe composition of schreibersite is very variable, but frequently polygons of iron, nickel‐cobalt, and phosphorus percentages strongly suggest that the formula is Fe2NiP. A secondary maximum in the nickel‐cobalt polygon, together with a study of the individual analyses, indicates that, in general, the phosphide known as rhabdite has somewhat more than the required quantity of nickel, while the more massive, “true” schreibersite contains somewhat less. References are given to work showing that schreibersite is body‐centered tetragonal. Schreibersite lamellae are known to occur parallel to (100), (210), (211), (110) (Brezina lamellae), and (111). The last‐mentioned form is described for the first time in connection with Widmanstätten figures in the Canyon Diablo, Arizona, meteorite. It is also somewhat different from a similar occurrence in the Rodeo, Durango, Mexico, meteorite. The name Shepard's lamellae is proposed for the lamellae parallel to (111).
Three New Siderites from Kentucky: Campbellsville, Clark County, and Providence*
Authors: Young David M. 
Published: June 2012

AbstractOn June 3, 1929, the seventeenth Kentucky meteorite (Campbellsville) was ploughed from a field by Mr. E. B. Watson on the farm of Edgar Cox, near Campbellsville, Taylor County, Kentucky. The original weight of the iron was 34 pounds, about one‐half of which has been distributed. It is classed as a coarse octahedrite (Og) and has the following chemical composition: iron, 88.99%; nickel, 10.27%; cobalt, 0.26%; and traces of carbon, silica, manganese, copper, and titanium.The eighteenth meteorite from Kentucky (Clark County) was found in 1937. It was purchased by Mr. J. D. Figgins of the Bernheim Museum, who exchanged most of it with the American Meteorite Laboratory, where it will be described. The original weight was 26 pounds.The latest identification of a siderite in Kentucky (Providence) was made in July, 1938, although the specimen was found 35 years before. Mr. W. T. Yeager, owner of a farm located about one mile southwest of Providence, Trimble County, Kentucky, found the iron in 1903 in an orchard where it was exposed at the surface of the ground. Unaware of its true character, but interested because of its weight, he kept the specimen as a curiosity until it became known to the writer. The weight is 15 pounds, and although badly oxidized, the coarse octahedral crystallization is well defined. The meteorite is classed as a coarse octahedrite (Og) and contains 88.54% iron, 10.30% nickel, 0.30% cobalt, etc.