bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: New Application of Heterocyclic Diazonium Salts. Synthesis of Pyrazolo[3,4‐d][1,2,3]triazin‐4‐ones and Imidazo[4,5‐d][1,2,3]triazin‐4‐ones.
Authors: Colomber Juan Pablo , Moyano Elizabeth Laura 
Published: June 2011

AbstractA one‐step conversion of aminopyrazoles of type (I) and analogous aminoimidazoles produces triazinones, structurally related to purines.
ChemInform Abstract: One‐Pot Multicoupling Reaction of Silylcopper Reagents, Organolithium Compounds and α,β‐Unsaturated Nitriles.
Authors: Pulido Francisco J. , Barbero Asuncion , Blanco Yolanda 
Published: June 2011

AbstractSilylcupration of allene using a lower order silylcopper reagent generates a vinylcuprate intermediate, which reacts with organolithium or Grignard reagent and an α,β‐unsaturated nitrile to give a 2‐(oxoalkyl)allylsilane derivative.
ChemInform Abstract: Copper‐Catalyzed Synthesis of Alkynylphosphine Derivatives: Unprecedented Use of Nucleophilic Phosphorus Compounds.
Authors: Bernoud Elise , Alayrac Carole , Delacroix Olivier , Gaumont Annie‐Claude 
Published: June 2011

AbstractA new and efficient access to various alkynylphosphine derivatives is developed using Cu‐catalyzed cross‐coupling reactions of secondary phosphine boranes with alkynyl bromides.
ChemInform Abstract: Synthesis of 10β‐Substituted Triazolyl Artemisinins and Their Growth Inhibitory Activity Against Various Cancer Cells.
Authors: Lee Seokjoon 
Published: June 2011

AbstractThe acid‐catalyzed reaction of dihydroartemisinin (III) with substituted triazoles (II) provides a library of 10‐substituted triazolyl artemisinins (IV), (V), and (VI).
ChemInform Abstract: Phosphate Mediated Biomimetic Synthesis of Tetrahydroisoquinoline Alkaloids.
Authors: Pesnot Thomas , Gershater Markus C. , Ward John M. , Hailes Helen C. 
Published: June 2011

AbstractThe modified Pictet—Spengler procedure uses the inorganic phosphate buffer as a mild but efficient catalytic system to afford a range of substituted isoquinolines (III) including norcoclaurine (IIId).
ChemInform Abstract: First and Efficient Synthesis of 14‐Aminophenanthroindolizidine Alkaloids.
Authors: Wang Ziwen , Wang Lei , Wang Qingmin 
Published: June 2011

AbstractA short route is developed for the synthesis of 14‐aminophenanthroindolizidines (VII) via dehydration of amides (III) with TFAA and Parham cyclization of resulting nitriles (IV).
ChemInform Abstract: Synthesis of 9‐Substituted Derivatives of Berberine as anti‐HIV Agents.
Authors: Bodiwala Hardik S. , Sabde Sudeep , Mitra Debashis , Bhutani Kamlesh Kumar , Singh Inder Pal 
Published: June 2011

AbstractDifferent berberine‐9‐O‐esters (I) are prepared and tested for their cytotoxicity and anti‐HIV activity.
ChemInform Abstract: The Novel anti‐Tumor Agents of 4‐Triazol‐1,8‐naphthalimides: Synthesis, Cytotoxicity, DNA Intercalation and Photocleavage.
Authors: Li Xiaolian , Lin Yanjie , Wang Qianqian , Yuan Yukun , Zhang Hua , Qian Xuhong 
Published: June 2011

AbstractTitle compounds (I) are easily synthesized by employing click reaction.
ChemInform Abstract: Synthesis of Active Metabolites of Carvedilol, an Antihypertensive Drug.
Authors: Senthilkumar N. , Somannavar Y. S. , Reddy Shankar B. , Sinha Brajesh Kumar , Narayan G. K. A. S. S. , Dandala Ramesh , Mukkanti Kaga 
Published: June 2011

AbstractThe compounds (I) can be synthesized starting from commercially available vanillin and isovanillin, respectively.
ChemInform Abstract: Multicomponent Reactions and Ionic Liquids: A Perfect Synergy for Eco‐Compatible Heterocyclic Synthesis
Authors: Isambert Nicolas , del Mar Sanchez Duque Maria , Plaquevent Jean‐Christophe , Genisson Yves , Rodriguez Jean , Constantieux Thierry 
Published: June 2011

AbstractReview: 73 refs.
ChemInform Abstract: New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
Authors: Sporn Michael B. , Liby Karen T. , Yore Mark M. , Fu Liangfeng , Lopchuk Justin M. , Gribble Gordon W. 
Published: June 2011

AbstractReview: 81 refs.
Pixantrone dimaleate in combination with fludarabine, dexamethasone, and rituximab in patients with relapsed or refractory indolent non‐Hodgkin lymphoma
Authors: Srokowski Tomasz P. , Liebmann James E. , Modiano Manuel R. , Cohen Gary I. , Pro Barbara , Romaguera Jorge E. , Kuepfer Christine , Singer Jack W. , Fayad Luis E. 
Published: June 2011

AbstractBACKGROUND:Pixantrone dimaleate (pixantrone) has been shown to have antitumor activity in leukemia and lymphoma in vitro models and to lack delayed cardiotoxicity associated with mitoxantrone in animal models. FND‐R, a combination regimen of fludarabine, mitoxantrone, dexamethasone, and rituximab, has been shown to be an effective regimen for low‐grade lymphomas.METHODS:This dose‐escalation study, with an expansion cohort, was conducted to evaluate the safety and preliminary efficacy of FPD‐R, in which pixantrone was substituted for mitoxantrone in the FND‐R regimen, in patients with relapsed or refractory indolent non‐Hodgkin lymphoma (NHL). Escalated doses of pixantrone were administered to newly enrolled patients on day 2 of each 28‐day cycle of FPD‐R.RESULTS:Twenty‐eight of 29 enrolled patients received at least 1 cycle of FPD‐R (median, 5 cycles). Pixantrone 120 mg/m2 was identified as the recommended dose in this regimen. Grade 3‐4 adverse events were primarily hematologic; grade 3‐4 lymphopenia occurred in 89% of patients and leukopenia in 79%. No patients developed congestive heart failure or grade 3‐4 cardiac adverse events. Left ventricular ejection fraction decreases occurred in 8 (29%) patients, and most were grade 1 or 2, transient, and asymptomatic. The overall response rate was 89%. Estimated survival was 96% after 1 year and 92% after 3 years.CONCLUSIONS:The FPD‐R regimen was well‐tolerated and highly active in patients with relapsed or refractory indolent NHL. Cancer 2011;. © 2011 American Cancer Society.
Examination of new vector control system of permanent magnet synchronous motor for high‐speed drives
Authors: Tobari Kazuaki , Endo Tsunehiro , Iwaji Yoshitaka , Ito Yoshiki 
Published: June 2011

AbstractA new vector control system for permanent magnet synchronous motor drives has been developed. To stabilize the current control loop in the high‐rotating‐speed region, a novel configuration of current controller is introduced. The unique characteristic of the proposed current controller is that the current regulator is connected to the conventional motor model in a series. By analyzing the transfer characteristics of the control, it became clear that the influence of the coupling component between the d–q axes can be deleted theoretically if the control parameters are set properly. The stability and torque response of the proposed vector control system were improved, and the effectiveness of the proposed controller was demonstrated by a time domain simulation and some experiments. In addition, the robustness of the controlling system was investigated experimentally. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(4): 61–72, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21123
Development of gate drive circuit for next‐generation ultrahigh‐speed switching devices
Authors: Noguchi Toshihiko , Yajima Satoshi , Komatsu Hiroyoshi 
Published: June 2011

AbstractThis paper describes a gate drive circuit which is capable of driving an ultrahigh‐speed switching device and of suppressing high‐frequency noise caused by its high dV/dt ratio of 104 V/μs order. SiC (silicon carbide)‐based power semiconductor devices are very promising as next‐generation ultrahigh‐speed switching devices. However, one of their application problems is how to drive them with less high‐frequency noise without sacrificing their ultrahigh‐speed operation capability. The paper proposes a new gate drive circuit specialized for such devices, which charges and discharges the input capacitance of the device by using an impulse voltage generated by inductors. This ultrahigh‐speed switching operation causes a high‐frequency common‐mode noise current in the gate drive circuit, which penetrates an isolated power‐supply transformer due to the parasitic capacitance between the primary and the secondary windings. In order to overcome this secondary problem, a toroidal multicore transformer is also proposed in the paper in order to reduce the parasitic capacitance drastically. By applying the former technique, the turn‐on time and turn‐off time of the power device were shortened by 50% and by 20%, compared with a conventional push‐pull gate drive circuit, respectively. In addition, the latter technique allows reduction of the peak common‐mode noise current to 25%, compared with the use of a conventional standard utility power‐supply transformer. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(4): 52–60, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21124
Influence of wind turbulence on yaw‐control gears in wind turbine
Authors: Suzuki Kazuo , Hoshino Naoki , Inomata Noboru , Kimura Hiroshi , Fujiwara Tamiya 
Published: June 2011

AbstractThis paper describes the influence of wind turbulence on the yaw‐control gears of the nacelle in a wind power station. The site is located on Tappi Cape in Aomori prefecture, where major wind turbulence occurs due to the strong western wind and the steep slope of the cape. This paper discusses two adjacent wind towers out of a total of eleven and clarifies the influence of wind turbulence on the leeward wind power generator. Measurements showed that the turbulence and the standard deviation frequently exceeded IEC Wind Turbine Standards. Consequently, the torque applied to the yaw‐control gears oscillated with a short time period and its magnitude was frequently greater than 4.8 ton‐m (47 kN‐m), regarded as the metal fatigue limit. By a method in which the output of the wind turbine generator is controlled, the magnitude of the oscillating torque can be reduced below the limit of material fatigue. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(4): 15–25, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21141
Determination method for loss‐minimum configuration considering reconnection of distributed generators
Authors: Takano Hirotaka , Tomida Takafumi , Hayashi Yasuhiro , Matsuki Junya 
Published: June 2011

AbstractIn the field of electrical power system, various approaches, such as utilization of renewable energy, loss reduction, and so on, have been taken to reduce CO2 emission. So as to work toward this goal, the total number of distributed generators (DGs) using renewable energy connected into 6.6‐kV distribution systems has been increasing rapidly. The DGs can reduce distribution loss by appropriate allocation. However, when a fault occurs such as distribution line fault and bank fault, DGs connecting outage sections are disconnected simultaneously. Since the simultaneous disconnection of DGs influences restoration configuration and normal configuration after the restoration, it is necessary to determine the system configuration in the normal state considering simultaneous disconnection of DGs.In this paper, the authors propose a computation method to determine the loss minimum configuration in the normal state considering reconnection of DGs after simultaneous disconnection by fault occurrence. The feature of determined loss minimum configuration is satisfying with operational constraints even if all DGs are disconnected from the system. Numerical simulations are carried out for a real‐scale distribution system model with 252 sectionalizing switches (configuration candidates are 2252) and 120 DGs (total output is 38.46 MW which is 23% of total load) in order to examine the validity of the proposed algorithm. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 176(4): 7–14, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21142
Complete Two‐Step Spin‐Transition in a 1D Chain Iron(II) Complex with a 110‐K Wide Intermediate Plateau
Authors: Bauer Wolfgang , Pfaffeneder Toni , Achterhold Klaus , Weber Birgit 
Published: June 2011

AbstractThree new spin crossover compounds [FeL1(azpy)] (1), [FeL1(azpy)]·toluene [1(tol)] and [FeL2(azpy)] (2), where L1 and L2 are the tetradentate N2O22– coordinating Schiff base like ligands {diethyl (E,E)‐2,2′‐[1,2‐phenyl‐bis(iminomethylidyne)]bis[3‐oxobutanoate]‐(2‐)‐N,N′,O3,O3′} and {dimethyl(E,E)‐2,2′‐[1,2‐phenyl‐bis(iminomethylidyne)]bis[3‐oxobutanoate]‐(2‐)‐N,N′,O3,O3′}, respectively, and azpy = 4,4′‐azopyridine are presented. All compounds have been investigated by using T‐dependent susceptibility measurements, and different types of spin transitions are observed. In the case of 1 and 2, intermediate plateaus (γHS ≈ 0.5) with widths of 110 and 75 K, respectively, were observed, while for 1(tol) a gradual spin transition is obtained. Upon heating of 1(tol) above 390 K, a loss of the included solvent molecule toluene is observed, which results in a two‐step spin transition of the tempered sample similar to that of 1. Mössbauer spectra of 1, 1(tol) and the tempered sample 1(temp) reveal two different iron(II) sites in the low‐spin (LS) state for all three samples. T‐dependent Mössbauer spectra indicate that the inequivalent iron centres are one but not the only reason for the wide plateau of 1. Results from X‐ray structure analysis of 1 in the region of the plateau show the presence of two inequivalent iron centres, of which one is in the high‐spin (HS) state and one in the low‐spin state. The 1D chains of alternating HS and LS iron centres are arranged in a parallel manner within one layer; between the different layers, the direction of the chains rotates by 90° relative to the previous one. This cross‐linked arrangement with an interlocking of the layers is most likely the reason for the appearance of the wide plateau.
First Evidence of the Oxidative Addition of Fe0(N,N)2 to Aryl Halides: This Precondition Is Not a Guarantee of Efficient Iron‐Catalysed C–N Cross‐Coupling Reactions
Authors: Lefèvre Guillaume , Taillefer Marc , Adamo Carlo , Ciofini Ilaria , Jutand Anny 
Published: June 2011

AbstractIt has been shown by cyclic voltammetry (CV) that the electrochemical reduction of [Fe(acac)3] in the presence of 1,10‐phenanthroline (phen; ≥2 equiv.) or FeCl3 in the presence of N,N′‐dimethylethylenediamine (dmeda; 2 equiv.) in DMF leads to [Fe0(phen)2] and [Fe0(dmeda)2], respectively. They undergo unprecedented oxidative addition to aryl halides to generate [ArFeIIX(phen)2] (X = I, Br) and [ArFeIIX(dmeda)2] (X = Br), characterized by CV, ESI‐MS and DFT. The order of reactivity in the oxidative addition was deduced by CV and supported by DFT: [Fe0(phen)2] < [Fe0(dmeda)2]. [ArFeIIX(phen)2] and [ArFeIIX(dmeda)2] are nucleophilic reagents (reaction with H+ and CO2) and do not react with the investigated N‐nucleophiles (imidazole or pyrazole) often tested as reagents in catalytic C–N cross‐coupling reactions, even in the presence of a base. Moreover, it has been established that {[Fe(acac)3] + 2 phen} and {FeCl3 + 2 dmeda} cannot be reduced in situ to Fe0(N,N)2 (precondition required to activate ArX) by N‐nucleophiles (pyrazole, imidazole) even in the presence of a base. All this explains why {[Fe(acac)3] + 2 phen} and {FeCl3 + 2 dmeda} are inefficient precatalysts for C–N cross‐couplings reactions, as recently reported in the literature.
Stereoselective Total Synthesis of Umuravumbolide
Authors: Shekhar Vanam , Reddy Dorigondla Kumar , Reddy Sudina Purushotham , Prabhakar Peddikotla , Venkateswarlu Yenamandra 
Published: June 2011

AbstractA simple and efficient stereoselective total synthesis of desacetylumuravumbolide (1a) and umuravumbolide (1b), starting from commercially available valeraldehyde has been described. The synthetic strategy involves a highly enantioselective zinc‐mediated addition of protected 2 alkyn‐1‐ol to aldehyde, a Crimmins aldol reaction, and Horner–Wadsworth–Emmons olefination as key steps.
Physicobiological properties and biocompatibility of biodegradable poly(oxalate‐co‐oxamide)
Authors: Song Yiseul , Kwon Jungil , Kim Byungkuk , Jeon Yuyong , Khang Gilson , Lee Dongwon 
Published: June 2011

AbstractThe development of biodegradable and biocompatible materials is the basis for tissue engineering and drug delivery. The aims of this study are to develop the poly(oxalate‐co‐oxamide) (POXAM) and evaluate its physicochemical properties and biocompatibility as the initial step for the development of new biomaterials. POXAM had a molecular weight of ∼70,000 Da and rapidly degraded under physiological condition with a half‐hydrolysis of ∼4 days. POXAM films exhibited relative hydrophilic nature because of the presence of oxamide linkages and induced a higher cell attachment and proliferation compared with poly(lactic‐co‐glycolic acid) (PLGA) films. In vitro inflammatory responses to POXAM were evaluated using murine macrophage RAW 264.7 cells. POXAM films minimally stimulated the cells to generate less production of tumor necrosis factor‐alpha (TNF‐α) than PLGA films. We assessed the in vivo inflammatory responses to POXAM films implanted in the dorsal skin of rats. Histological studies revealed that POXAM provoked remarkably reduced inflammatory responses, evidenced by the less accumulation of inflammatory cells and giant cells, thinner fibrotic capsules, in comparison with PLGA. Given its excellent biocompatibility, fast degradation, and very mild inflammatory responses, POXAM has great potential for biomedical applications, such as scaffolds, wound dressing, and fast drug delivery. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Poly(dimethyl siloxane) surface modification with biosurfactants isolated from probiotic strains
Authors: Pinto S. , Alves P. , Santos A. C. , Matos C. M. , Oliveiros B. , Gonçalves S. , Gudiña E. , Rodrigues L. R. , Teixeira J. A. , Gil M. H. 
Published: June 2011

AbstractDepending on the final application envisaged for a given biomaterial, many surfaces must be modified before use. The material performance in a biological environment is mainly mediated by its surface properties that can be improved using suitable modification methods. The aim of this work was to coat poly(dimethyl siloxane) (PDMS) surfaces with biosurfactants (BSs) and to evaluate how these compounds affect the PDMS surface properties. BSs isolated from four probiotic strains (Lactococcus lactis, Lactobacillus paracasei, Streptococcus thermophilus A, and Streptococcus thermophilus B) were used. Bare PDMS and PDMS coated with BSs were characterized by contact angle measurements, infrared spectroscopy (ATR‐FTIR), X‐ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The influence of the surface modifications on the materials blood compatibility was studied through thrombosis and hemolysis assays. The cytotoxicity of these materials was tested against rat peritoneal macrophages. AFM results demonstrated the successful coating of the surfaces. Also, by contact angle measurements, an increase of the coated surfaces hydrophilicity was seen. Furthermore, XPS analysis indicated a decrease of the silicon content at the surface, and ATR‐FTIR results showed the presence of BS characteristic groups as a consequence of the modification. All the studied materials revealed no toxicity and were found to be nonhemolytic. The proposed approach for the modification of PDMS surfaces was found to be effective and opens new possibilities for the application of these surfaces in the biomedical field. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Estrogen inhibits Dlk1/FA1 production: A potential mechanism for estrogen effects on bone turnover
Authors: Abdallah Basem M , Bay-Jensen Anne-Christine , Srinivasan Bhuma , Tabassi Nadine C , Garnero Patrick , Delaissé Jean-Marie , Khosla Sundeep , Kassem Moustapha 
Published: June 2011

Abstract
We have recently identified delta-like 1/fetal antigen 1 (Dlk1/FA1) as a novel regulator of bone mass that functions to mediate bone loss under estrogen deficiency in mice. In this report, we investigated the effects of estrogen (E) deficiency and E replacement on serum (s) levels of Dlk1/FA1 (s-Dlk1FA1) and its correlation with bone turnover markers. s-Dlk1/FA1 and bone turnover markers (serum cross-linked C-telopeptide [s-CTX] and serum osteocalcin) were measured in two cohorts: a group of pre- and postmenopausal women (n = 100) and a group of postmenopausal women, where half had received estrogen-replacement therapy (ERT, n = 166). s-Dlk1/FA1 and s-CTX were elevated in postmenopausal E-deficient women compared with premenopausal E-replete women (both p &lt; 0.001). s-Dlk1/FA1 was correlated with s-CTX (r = 0.30, p &lt; 0.01). ERT in postmenopausal women decreased s-Dlk1/FA1, as well as s-CTX and s-osteoclacin (all p &lt; .0001). Changes in s-Dlk1 were significantly correlated with those observed in s-CTX (r = 0.18, p &lt; 0.05) and s-osteocalcin (r = 0.28, p &lt; 0.001). In conclusion, s-Dlk1/FA1 is influenced by E-deficiency and is correlated with bone turnover. Increased levels of s-Dlk1/FA1 in postmenopausal women may be a mechanism mediating the effects of estrogen deficiency on bone turnover. © 2011 American Society for Bone and Mineral Research
Thymoquinone‐induced platelet apoptosis
Authors: Towhid Syeda Tasneem , Schmidt Eva‐Maria , Schmid Evi , Münzer Patrick , Qadri Syed M. , Borst Oliver , Lang Florian 
Published: June 2011

AbstractThymoquinone (TQ) is a nutrient with anticarcinogenic activity that stimulates suicidal death of tumor cells. Moreover, TQ triggers suicidal death of erythrocytes or eryptosis, an effect at least partially due to increase in cytosolic Ca2+ activity and ceramide formation. The present experiments explored whether TQ influences apoptosis of blood platelets. Cell membrane scrambling was determined utilizing Annexin V binding to phosphatidylserine exposing platelets, cytosolic Ca2+ activity utilizing Fluo 3‐AM fluorescence, caspase activity utilizing immunofluorescence and Western blotting of active caspase‐3 and inactive procaspase‐3, mitochondrial potential utilizing DiOC6 fluorescence and ceramide by FACS analysis of ceramide‐binding antibodies. A 30 min exposure to TQ (≥5 µM) was followed by Annexin V binding, paralleled by caspase activation, increase of cytosolic Ca2+ activity, mitochondrial depolarization, and ceramide formation. P‐selectin exposure and integrin αIIbβ3 activation did not increase in response to TQ. Nominal absence of extracellular Ca2+ blunted but did not fully abolish the TQ‐induced activation of caspase‐3. The effects of TQ on platelets are significantly abolished with phosphoinositide‐3 kinase (PI3K) inhibitor wortmannin and G‐protein coupled receptor (GPCR) inhibitor pertussis toxin treatment prior to TQ stimulation. In conclusion, TQ triggers suicidal death of blood platelets in a PI3K‐dependent manner, possibly through a GPCR family receptor; an effect paralleled by increase of cytosolic Ca2+ activity, ceramide formation, mitochondrial depolarization, and caspase‐3 activation. J. Cell. Biochem. 112: 3112–3121, 2011. © 2011 Wiley Periodicals, Inc.