bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Intracoronary Autologous Bone Marrow‐Derived Cell Transplantation in Patients With Acute Myocardial Infarction: Insights From Randomized Controlled Trials With 12 or More Months Follow‐Up
Authors: Zhang Chunyu , Sun Aijun , Zhang Shuning , Yao Kang , Wu Chaoneng , Fu Mingqiang , Wang Keqiang , Zou Yunzeng , Ge Junbo 
Published: June 2010

AbstractBackgroundUntil now there was no systematic review concerning the chronic effects of intracoronary bone marrow‐derived cell (BMC) transplantation in patients with acute myocardial infarction (MI).HypothesisImprovement of cardiac function in patients with acute MI post BMC transplantation might last longer than 12 months.MethodsWe searched MEDLINE, EMBASE, and the Cochrane database through June 2009. Eligible studies were randomized controlled trials of intracoronary BMC transfer in acute MI patients with follow‐up duration equal to or longer than 12 months.ResultsA total of 8 trials involving 725 participants were identified. Compared with controls, BMC transplantation significantly improved left ventricular ejection fraction (LVEF) by 4.37% (95% confidence interval [CI]: 2.66%–6.08%; P < 0.00001), reduced left ventricular end‐diastolic volume (LVEDV) by 5.71 mL (95% CI: 2.03–9.40 mL; P = 0.002), left ventricular end‐systolic volume (LVESV) by 8.94 mL (95% CI: 4.22–13.66 mL; P = 0.0002), and infarct size by 2.42% (95% CI: 1.33%–3.51%, P < 0.00001). Bone marrow‐derived cell treatment also significantly reduced the risk of death (relative risk [RR]: 0.33, 95% CI: 0.13–0.89; P = 0.03), while the risk of reinfarction was similar between the 2 groups (RR: 0.62, 95% CI: 0.09–4.12; P = 0.62). Subgroup analysis showed that the BMC transplantation‐induced LVEF increase was more significant in patients age < 55 and with cells transferred 6 or 7 days after MI.ConclusionBeneficial effects of intracoronary BMC transplantation could last more than 12 months in acute MI patients. Copyright © 2010 Wiley Periodicals, Inc.
QT Prolongation Is an Independent Predictor of Mortality in End‐Stage Renal Disease
Authors: Hage Fadi G. , de Mattos Angelo M. , Khamash Hasan , Mehta Shikha , Warnock David , Iskandrian Ami E. 
Published: June 2010

AbstractBackgroundCoronary artery disease (CAD) is the predominant cause of sudden cardiac death in the general population, and sudden cardiac death is the leading cause of mortality in end‐stage renal disease (ESRD).HypothesisQT‐interval prolongation is an independent prognosticator in ESRD.MethodsWe reviewed clinical, electrocardiographic, stress test, and coronary angiography data on ESRD patients evaluated for transplantation at our institution between 2000 and 2004 who underwent coronary angiography. The QT interval was corrected for heart rate and QRS duration (QTc). All‐cause mortality data were prospectively collected and verified against the Social Security Death Index database.ResultsDuring 40 ± 28 months of follow‐up, 132 of the 280 (47%) patients died prior to renal transplantation. Patients with a prolonged QTc (39%) had 1‐, 3‐, and 5‐year death‐rates of 12%, 36%, and 47%, respectively, vs 8%, 24%, and 36% for those with normal QTc (log‐rank P = 0.03). In a multivariate Cox regression model that adjusted for age, gender, diabetes mellitus, myocardial infarction, presence and severity of CAD on angiography, left ventricular (LV) hypertrophy, LV ejection fraction (EF), and multiple other variables, QTc remained to be an independent predictor of survival (hazard ratio [HR]: 1.008, 95% confidence interval [CI]: 1.001–1.014, P = 0.016). Female gender, decreasing LVEF, and decreasing severity of CAD on angiography were independent predictors of prolonged QTc.ConclusionsQTc prolongation is an independent predictor of mortality in ESRD patients being evaluated for renal transplantation. The prognostic information gained from the QTc is additive to that provided by the LVEF and the severity of CAD. Copyright © 2010 Wiley Periodicals, Inc.
Possible Participation of Endothelial Cell Apoptosis of Coronary Microvessels in the Genesis of Takotsubo Cardiomyopathy
Authors: Uchida Yasumi , Egami Haruko , Uchida Yasuto , Sakurai Takeshi , Kanai Masahito , Shirai Seiichiro , Nakagawa Osamu , Oshima Tomomitsu 
Published: June 2010

AbstractBackgroundTakotsubo cardiomyopathy (TCM) is characterized by systolic ballooning of the left ventricular apex. It is triggered by emotional or physical stress, but the exact mechanism through which stress leads to TCM is not known.HypothesisCoronary microvessel apoptosis is the missing link between stress and TCM.MethodsIn 8 female patients with TCM, plasma catecholamines, Thrombolysis in Myocardial Infarction (TIMI) coronary flow grade and myocardial perfusion grade, and apoptosis of the coronary microvessels in the biopsied myocardial specimen by terminal deoxynucleotidyl transferase‐mediated nick end‐labeling (TUNEL) were examined.ResultsPlasma epinephrine and norepinephrine were increased to 663 ± 445 and 875 ± 812 pg/mL (mean ± SD), respectively. Acetylcholine‐induced delayed myocardial perfusion through the ballooning apical segment without flow disturbance in the epicardial coronary arteries (indicating microvessel spasm) and focal myocardial necrosis were observed in all subjects. Apical ballooning disappeared and myocardial perfusion delay was not inducible 1 month later. The number of vessels having apoptotic endothelial cells/10 vessels in arterioles, venules, and capillaries at initial biopsy and repeat biopsy 1 month later were 8.3 ± 1.4 vs 0.4 ± 1.1, P < 0.0001; 6.8 ± 1.8 vs 0.3 ± 0.7, P < 0.0001; and 7.9 ± 1.0 vs 0.5 ± 0.9, P < 0.0001, respectively.ConclusionsLeft ventricular apical ballooning in TCM was considered to be caused by coronary microvessel spasm due to catecholamine‐induced endothelial cell apoptosis and myocardial stunning after release of microvessel spasm. Endothelial cell apoptosis of coronary microvessel is therefore considered to be the missing link between stress and TCM. Copyright © 2010 Wiley Periodicals, Inc.
Natriuretic and Neurohormonal Responses to Nesiritide, Furosemide, and Combined Nesiritide and Furosemide in Patients With Stable Systolic Dysfunction
Authors: Sica Domenic , Oren Ron M. , Gottwald Mildred D. , Mills Roger M. ,   for the Scios 351 Investigators
Published: June 2010

AbstractBackgroundIn patients with heart failure, few data describe the neurohormonal response to nesiritide and furosemide either alone or in combination. This study systematically compared the effects of nesiritide, furosemide, and their combination on natriuresis/diuresis and plasma aldosterone in patients with chronic stable heart failure who were relatively diuretic resistant.HypothesisNatriuretic, diuretic, and neurohormonal responses to furosemide and nesiritide will differ when these agents are administered alone vs. in combination.MethodsTwenty‐eight subjects completed a multicenter, open‐label, three‐arm crossover study. Each subject received the following treatments in random order on alternate days: (1) furosemide, 40 mg intravenous bolus; (2) nesiritide, 2 µg/kg intravenous bolus followed by a 0.01 µg/kg/min infusion for 6 hours; (3) both furosemide and nesiritide, with furosemide given at least 15 minutes after initiation of nesiritide.ResultsPlasma aldosterone increased by 2.2 ± 1.6 ng/dL after furosemide alone, decreased by 3.9 ± 1.6 ng/dL after nesiritide alone (P = 0.005 vs furosemide alone and P = 0.56 vs furosemide plus nesiritide), and decreased by 2.8 ± 1.6 ng/dL after furosemide plus nesiritide (P = 0.02 vs furosemide alone).ConclusionsFurosemide alone produced natriuresis/diuresis and a prompt rise in plasma aldosterone values. Nesiritide alone produced no significant natriuresis/diuresis, but decreased plasma aldosterone values. When furosemide was administered on a background of nesiritide infusion, the observed natriuresis/diuresis was similar to that seen with furosemide alone, without the anticipated increase in plasma aldosterone observed with furosemide alone. Copyright © 2010 Wiley Periodicals, Inc.
A graphical generalized implementation of SENSE reconstruction using Matlab
Authors: Omer Hammad , Dickinson Robert 
Published: June 2010

AbstractParallel acquisition of Magnetic Resonance Imaging (MRI) has the potential to significantly reduce the scan time. SENSE is one of the many techniques for the reconstruction of parallel MRI images. A generalized algorithm for SENSE reconstruction and theoretical background is presented. This algorithm can be used for SENSE reconstruction for any acceleration factor between 2 and 8, for any Phase Encode direction (Horizontal or Vertical), with or without Regularization. The user can select a particular type of Regularization. A GUI based implementation of the algorithm is also given. Signal‐to‐noise ratio, artefact power, andg‐factor map are used to quantify the quality of reconstruction. The effects of different acceleration factors on these parameters are also discussed. The GUI based implementation of SENSE reconstruction provides an easy selection of various parameters needed for reconstruction of parallel MRI images and helps in an efficient reconstruction and analysis of the quality of reconstruction. © 2010 Wiley Periodicals, Inc. Concepts Magn Reson Part A 36A: 178–186, 2010.
Cardiovascular Adjustments to Isometric Contractions: Static Effort
Authors: Lind Alexander R. 
Published: June 2010

AbstractThe sections in this article are:General Description of Cardiovascular ResponsesLocal CirculationCardiac and Systemic Vascular ResponsesBaroreceptor InfluenceMechanisms of Control of Systemic Cardiovascular ResponsesEfferent PathwayAfferent PathwaySummary: Central Command or Reflex?
Cardiovascular Adjustments to Thermal Stress
Authors: Rowell Loring B. 
Published: June 2010

AbstractThe sections in this article are:Critique of Some Methods Employed in HumansTotal and Regional Cutaneous Blood FlowCardiac OutputCentral Blood VolumeRegional Blood FlowMeasurement of TemperatureGeneral Features of the Cutaneous Circulation: A Brief ReviewCutaneous Blood FlowCutaneous Blood VolumeInnervation of Cutaneous ArteriolesLocal Control of Skin Blood Flow: Interaction With ReflexesReflex and Local Control of Cutaneous VeinsCirculatory Adjustments to Heat Stress in Resting HumansChanges in Cardiac Output, Blood Pressure, and Blood VolumeDistribution of Cardiac Output in Heat‐Stressed Resting HumansCardiac Output and Its Distribution in Heat‐Stressed Resting Subhuman SpeciesDistribution of Blood Volume in Heat‐Stressed Resting HumansMechanisms of Blood Flow Redistribution in RestAcclimatization in RestInteraction Between Thermoregulatory and Nonthermoregulatory Reflexes in Control of Skin Blood FlowCutaneous Vascular Responses to BaroreflexesCardiopulmonary (Low‐Pressure) BaroreflexPostural Influences: Hydrostatic ProblemUpright Posture in Heat Stress: Interaction Between Reflex Vasoconstriction and VasodilationExercisePossible Modes of Reflex Interaction: Unsolved ProblemsOverall Circulatory Adjustments to Heat Stress and ExerciseDistribution of Blood VolumeRedistribution of Blood Flow During ExerciseCentral CirculationAdaptation to Heat Stress and Exercise: Acclimatization
New Method for H2S Removal in Acid Solutions
Authors: de Angelis Alberto , Bellussi Giuseppe , Pollesel Paolo , Perego Carlo 
Published: June 2010

AbstractSeveral different technologies are available for H2S removal from the gas stream of medium capacity. Among them, the most widely used is Locat with more than 120 plants worldwide. In the last decade, many new processes, such as Sulfatreat‐DO, Crystasulf, Caltech, and UCSR, were proposed to overcome the drawbacks of the state‐of‐the‐art processes (low sulfur purity, chemical degradation, thiosulfate formation). We have developed a new H2S conversion method based on acid ferric nitrate solution, co‐catalyzed by a heteropolyacid. H2S was converted to pure sulfur (>99.9 %), with no traces of organic compounds. Due to the acid pH of the solution, no chelant or surfactant was needed and iron content in the solution could reach very high levels. Keggin heteropolyacid (H6PW9V3O40) catalyzed the reoxidation of reduced ferrous solution with air at mild temperature and at very high reaction rate. The undesired side reaction (NOx formation) could be avoided by simply increasing the oxygen partial pressure.
Metallic Plate Corrosion and Uptake of Corrosion Products by Nafion in Polymer Electrolyte Membrane Fuel Cells
Authors: Bozzini Benedetto , Gianoncelli Alessandra , Kaulich Burkhard , Kiskinova Maya , Prasciolu Mauro , Sgura Ivonne 
Published: June 2010

AbstractNafion contamination by ferrous‐alloy corrosion products, resulting in dramatic drops of the Ohmic potential, is a suspected major failure mode of polymer electrolyte membrane fuel cells that make use of metallic bipolar plates. This study demonstrates the potential of scanning transmission X‐ray microscopy combined with X‐ray absorption and fluorescence microspectroscopy for exploring corrosion processes of Ni and Fe electrodes in contact with a hydrated Nafion film in a thin‐layer cell. The imaged morphology changes of the Ni and Fe electrodes and surrounding Nafion film that result from relevant electrochemical processes are correlated to the spatial distribution, local concentration, and chemical state of Fe and Ni species. The X‐ray fluorescence maps and absorption spectra, sampled at different locations, show diffusion of corrosion products within the Nafion film only in the case of the Fe electrodes, whereas the Ni electrodes appear corrosion resistant.
Genetic algorithm‐based scheduling in cognitive radio networks under interference temperature constraints
Authors: Gözüpek Didem , Alagöz Fatih 
Published: June 2010

AbstractThe proliferation of wireless technologies and services has intensified the demand for the radio spectrum. However, the currently existing fixed spectrum assignment policy leads to an inefficient and unevenly distributed spectrum utilization. Cognitive radio paradigm has been proposed to alleviate these drawbacks by employing dynamic spectrum access (DSA) methodology. Federal Communications Commission (FCC) has proposed the interference temperature model, which enables the unlicensed users to utilize the licensed frequencies simultaneously with the licensed users as long as they conform to the interference temperature constraints. Recently, throughput and delay optimal schedulers that meet the interference temperature constraints in cognitive radio networks have been formulated in the literature. However, these schedulers have high computational complexity. In this paper, we propose genetic algorithm (GA)‐based suboptimal methods addressing these throughput and delay optimal scheduling problems. The simulation results corroborate that our GA‐based approach yields very close performance to the optimal solutions and operates with much lower complexity. Copyright © 2010 John Wiley & Sons, Ltd.
Change processes in residential cognitive therapy for bulimia nervosa
Authors: Hoffart Asle , Lysebo Hanne , Sommerfeldt Bente , Rø Øyvind 
Published: June 2010

AbstractThe purpose of the study was to examine the relationships of process variables derived from the cognitive model of bulimia nervosa (BN) and weekly outcome. The participants were 39 patients with BN or subthreshold bulimia consecutively admitted to an inpatient treatment program for bulimia. Theory‐derived process and outcome variables were measured repeatedly during the course of therapy with a gap of a week between each measurement. The data were analysed with time series methods (ARIMA). Weekly variations in the process variables: self‐efficacy about resisting binge eating, dysfunctional beliefs, negative affect and positive affect influenced variations in subsequent outcome, whereas weekly outcome did not influence subsequent process. These results are consistent with the cognitive model of BN and suggest that self‐efficacy, dysfunctional beliefs, negative affect and positive affect are potential targets for treatment that need further investigation. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.
Family planning and fertility decline in rural Iran: the impact of rural health clinics
Authors: Salehi‐Isfahani Djavad , Abbasi‐Shavazi M. Jalal , Hosseini‐Chavoshi Meimanat 
Published: June 2010

AbstractDuring the first few years of the Islamic Revolution of 1979, and aided by pro‐natal government policies, Iranian fertility was on the rise. In a reversal of its population policy, in 1989, the government launched an ambitious and innovative family planning program aimed at rural families. By 2005, the program had covered more than 90% of the rural population and the average number of births per rural woman had declined to replacement level from about 8 births in the mid 1980s. In this paper, we evaluate the impact of a particular feature of the program – health houses – on rural fertility, taking advantage of the variation in the timing of their construction across the country. We use three different methods to obtain a range of estimates for the impact of health houses on village‐level fertility: difference‐in‐differences (DID), matching DID, and length of exposure. We find estimates of impact ranging from 4 to 20% of the decline in fertility during 1986–1996. Copyright © 2010 John Wiley & Sons, Ltd.
Histone Deacetylase Inhibition Suppresses the Transforming Growth Factor β1-Induced Epithelial-to-Mesenchymal Transition in Hepatocytes†,‡
Authors: Kaimori Aki , Potter James J. , Choti Michael , Ding Zhen , Mezey Esteban , Koteish Ayman A. 
Published: June 2010

Abstract

Transforming growth factor β1 (TGFβ1) plays a crucial role in the induction of the epithelial-to-mesenchymal transition (EMT) in hepatocytes, which contributes to the pathogenesis of liver fibrosis. The inhibition of the TGFβ1 cascade suppresses EMT and the resultant fibrosis. In this study, we focus on EMT-induced fibrosis in hepatocytes and the epigenetic regulation of the type I collagen gene. Histone acetylation is an important, major epigenetic mechanism that modulates gene transcription. We evaluated the epigenetic regulation of type I collagen in alpha mouse liver 12 hepatocytes (an untransformed mouse cell line) that had undergone EMT after treatment with TGFβ1. The histone deacetylase inhibitor trichostatin A (TSA) inhibited EMT; this was reflected by the preservation of epithelial markers and function (E-cadherin and albumin). Fibrosis, the ultimate outcome of EMT, was abolished by TSA; this was indicated by the inhibition of type I collagen deposition. TSA exerted its anti-EMT effects by deactivating the mothers against decapentaplegic homolog 3 (Smad3)/Smad4 transcription complex and by interfering with p300, a coactivator of the type I collagen promoter, and preventing its binding to Smad3. TSA also restored Friend leukemia virus integration 1, an inhibitor of the type I collagen gene. TGFβ1-induced EMT and its inhibition by TSA were replicated in human primary hepatocytes.

Conclusion:

Histone deacetylase inhibition abrogates TGFβ1-induced EMT in hepatocytes and reverses EMT-induced fibrosis by epigenetic modulation of type I collagen.
Patatin-Like Phospholipase Domain-Containing 3/Adiponutrin Deficiency in Mice Is Not Associated with Fatty Liver Disease†,‡
Authors: Chen Weiqin , Chang Benny , Li Lan , Chan Lawrence 
Published: June 2010

Abstract

PNPLA3 (adiponutrin), a novel patatin-like phospholipase domain-containing enzyme, is expressed at high level in fat, but also in other tissues including liver. Polymorphisms in

PNPLA3

have been linked to obesity and insulin sensitivity. Notably, a nonsynonymous variant rs738409(G) allele of the

PNPLA3

gene was found to be strongly associated with both nonalcoholic and alcoholic fatty liver disease. We have generated

Pnpla3

−/−

mice by gene targeting. Loss of Pnpla3 has no effect on body weight or composition, adipose mass, or development, whether the mice were fed regular chow or high-fat diet or bred into the genetic obese

Lep

ob/ob

background. Plasma and liver triglyceride content and plasma aspartate aminotransferase and alanine aminotransferase levels were not different between

Pnpla3

+/+

and

Pnpla3

−/− mice while they were on regular chow, fed three different fatty liver-inducing diets, or after they were bred into

Lep

ob/ob

background. Hepatic Pnpla5 messenger RNA (mRNA) levels were similar in wild-type and

Pnpla3

−/− mice, although adipose Pnpla5 mRNA level was increased in

Pnpla3

−/− mice. A high-sucrose lipogenic diet stimulated hepatic Pnpla3 and Pnpla5 mRNA levels to a similar degree, but it did not affect adipose or liver triglyceride lipase (ATGL, known also as Pnpla2) mRNA in

Pnpla3

+/+ and

Pnpla3

−/−

mice. Finally,

Pnpla3

+/+

and

Pnpla3

−/−

mice displayed similar glucose tolerance and insulin tolerance tests while on regular chow or three different fatty liver–inducing diets.

Conclusion:

Loss of Pnpla3 does not cause fatty liver, liver enzyme elevation, or insulin resistance in mice.
Total Synthesis of the Biologically Active, Naturally Occurring 3,4‐Dibromo‐5‐[2‐bromo‐3,4‐dihydroxy‐6‐(methoxymethyl)benzyl]benzene‐1,2‐diol and Regioselective O‐Demethylation of Aryl Methyl Ethers
Authors: Akbaba Yusuf , Türker Balaydın Halis , Göksu Süleyman , Şahin Ertan , Menzek Abdullah 
Published: June 2010

Abstract3,4‐Dibromo‐5‐[2‐bromo‐3,4‐dihydroxy‐6‐(methoxymethyl)benzyl]benzene‐1,2‐diol (2), a natural product, has been synthesized for the first time starting from (3‐bromo‐4,5‐dimethoxyphenyl)methanol (5) in five steps and with an overall yield of 34%. The reaction of some methoxymethyl‐substituted aryl methyl ethers with BBr3, followed by the addition of MeOH, afforded the corresponding methoxymethyl‐substituted arylphenols in high yields.
Two New Steroidal Saponins from the Processed Polygonatum kingianum
Authors: Yu He‐Shui , Ma Bai‐Ping , Song Xin‐Bo , Kang Li‐Ping , Zhang Tao , Fu Jing , Zhao Yang , Xiong Cheng‐Qi , Tan Da‐Wei , Zhang Li‐Juan , Zhang Jie , Yu Kate 
Published: June 2010

AbstractTwo new spirostanol saponins, kingianoside I (1) and kingianoside K (2), corresponding to (3β,23S,25R)‐23‐hydroxy‐12‐oxospirost‐5‐en‐3‐yl 4‐O‐β‐D‐glucopyranosyl‐β‐D‐galactopyranoside (1) and (3β,25R)‐7‐oxospirost‐5‐en‐3‐yl α‐L‐arabinofuranosyl‐(1→4)‐[6‐deoxy‐α‐L‐mannopyranosyl‐(1→2)]‐β‐D‐glucopyranoside (2), along with 13 known compounds, daucosterol, (25R)‐kingianoside G, (25RS)‐kingianoside A, pratioside D1, (25RS)‐pratioside D1, (25S)‐kingianoside C, kingianoside C, ginsenoside Rb1, saponins Tb and Pb, dioscin, gracillin, and saponin Pa, were isolated from the processed rhizomes of Polygonatum kingianum. The structures of the new compounds were elucidated by detailed spectroscopic analyses, including 1D‐ and 2D‐NMR techniques, and chemical methods. Compound 2 contains a novel unusual spirostanol saponin aglycone. Ginsenoside Rb1 and saponin Tb were isolated for the first time from the genus Polygonatum. The 13 known compounds were detected for the first time in the processed Polygonatum kingianum.
The Synthesis, Photophysical Characterization, and X‐Ray Structure Analysis of Two Polymorphs of 4,4′‐Diacetylstilbene
Authors: Pye Cameron , Fronczek Frank R. , Isovitsch Ralph 
Published: June 2010

AbstractA palladium(II) acetate‐catalyzed synthesis of 1 that utilizes the novel triazene 1‐{4‐[(E)‐morpholin‐4‐yldiazenyl]phenyl}ethanone as a synthon is described. The room temperature absorption spectra of 1 in various solvents exhibited a π→π* transition in the range of 330–350 nm. Compound 1 was observed to be luminescent, with room‐temperature solution and solid‐state emission spectra that exhibited maxima in the range 400–500 nm. All room‐temperature absorption and emission spectra exhibited some degree of vibrational structure. The emission spectrum of 1 at 77 K in propanenitrile glass was broad and featureless with a maximum at 447 nm. Compound 1 crystallized as a yellow and colorless polymorph. X‐Ray structure analyses of both of these polymorphs and 1‐{4‐[(E)‐morpholin‐4‐yldiazenyl]phenyl}ethanone are presented.