bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Lundurines A, B and C, New Indole Alkaloids with a Novel Carbon Skeleton Containing a Cyclopropyl Moiety.
Authors: KAM T.‐S. , YOGANATHAN K. , CHUAH C.‐H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of 2′‐Deoxy‐2′‐arafluorotoyocamycin and Related Nucleosides.
Authors: BHATTACHARYA B. K. , REVANKAR G. R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mode of Coordination and Stability of Cu(II) and Zn(II) Complexes with Adenosine, Deoxyadenosine, Cytidine and Deoxycytidine.
Authors: GASOWSKA A. , LOMOZIK L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Complex Formation Between Gadolinium(III) Tetraphenylporphyrin and Vitamin E.
Authors: RADZKI S. , KRAUSZ P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Berninamycins B, C, and D, Minor Metabolites from Streptomyces bernensis.
Authors: LAU R. C. M. , RINEHART K. L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Matlystatins, New Inhibitors of Type IV Collagenases from Actinomadura atramentaria. Part 3. Structure Elucidation of Matlystatins A to F.
Authors: HARUYAMA H. , OHKUMA Y. , NAGAKI H. , OGITA T. , TAMAKI K. , KINOSHITA T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NK372135s, Novel Antifungal Agents Produced by Neosartoria fischeri.
Authors: MORINO T. , NISHIMOTO M. , ITOU N. , NISHIKIORI T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Ardisiaquinone A, a Potent 5‐Lipoxygenase Inhibitor, Isolated from Ardisia sieboldii, and Degree of 5‐Lipoxygenase Inhibitory Activity of Its Derivatives.
Authors: FUKUYAMA Y. , KIRIYAMA Y. , KODAMA M. , IWAKI H. , HOSOZAWA S. , AKI S. , MATSUI K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Steric Control of Selectivity for Lanthanoids in Liquid‐Liquid Extraction with Tris‐ and Tetrakis(pyrazol‐1‐yl)borate‐β‐Diketon Mixed‐Ligand Systems.
Authors: KOKUSEN H. , SOHRIN Y. , HASEGAWA H. , KIHARA S. , MATSUI M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A General Synthetic Strategy for Functionalized Oligo(bipyridines): New Building Blocks for Supramolecular Chemistry and Their First Application in Macromolecules.
Authors: EISENBACH C. D. , SCHUBERT U. S. , BAKER G. R. , NEWKOME G. R. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New NO‐Donors with Antithrombotic and Vasodilating Activities. Part 9. Thiadiazole Nitrosimines.
Authors: REHSE K. , LUEDTKE E. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Al‐B (Aluminum‐Boron) System
Authors: DUSCHANEK H. , ROGL P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zeolites and Zeolite‐Based Catalysts
Authors: KOTASTHANE A. N. , SHIRALKAR V. P. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quinquevalent Phosphorus Acids
Authors: EDMUNDSON R. S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Introduction (to Mass Spectrometry in Organic Stereochemistry)
Authors: SPLITTER J. S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereochemical Effects in the Fragmentation Processes of Saturated and Unsaturated Acyclic Molecular Ions
Authors: SPLITTER J. S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fine Feathers Make Fine Birds: Heck‐Reaction in a New Garment
Authors: DE MEIJERE A. , MEYER F. E. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: NMR Spectroscopy of Bulk Oxide Catalysts
Authors: ECKERT H. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mutated KRAS results in overexpression of DUSP4, a MAP‐kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas
Authors: Gaedcke Jochen , Grade Marian , Jung Klaus , Camps Jordi , Jo Peter , Emons Georg , Gehoff Anastasia , Sax Ulrich , Schirmer Markus , Becker Heinz , Beissbarth Tim , Ried Thomas , Ghadimi B. Michael 
Published: August 2010

AbstractMutations of the KRAS oncogene are predictive for resistance to treatment with antibodies against the epithelial growth factor receptor in patients with colorectal cancer. Overcoming this therapeutic dilemma could potentially be achieved by the introduction of drugs that inhibit signaling pathways that are activated by KRAS mutations. To identify comprehensively such signaling pathways, we profiled pretreatment biopsies and normal mucosa from 65 patients with locally advanced rectal cancer—30 of which carried mutated KRAS—using global gene expression microarrays. By comparing all tumor tissues exclusively to matched normal mucosa, we could improve assay sensitivity, and identified a total of 22,297 features that were differentially expressed (adjusted P‐value <0.05) between normal mucosa and cancer, including several novel potential rectal cancer genes. We then used this comprehensive description of the rectal cancer transcriptome as the baseline for identifying KRAS‐dependent alterations. The presence of activating KRAS mutations is significantly correlated to an upregulation of 13 genes (adjusted P‐value <0.05), among them DUSP4, a MAP‐kinase phosphatase, and SMYD3, a histone methyltransferase. Inhibition of the expression of both genes has previously been shown using the MEK1‐inhibitor PD98059 and the antibacterial compound Novobiocin, respectively. These findings suggest a potential approach to overcome resistance to treatment with antibodies against the epithelial growth factor receptor in patients with KRAS‐mutant rectal carcinomas. © 2010 Wiley‐Liss, Inc.
In vivo diagnosis of gastric cancer using Raman endoscopy and ant colony optimization techniques
Authors: Bergholt Mads Sylvest , Zheng Wei , Lin Kan , Ho Khek Yu , Teh Ming , Yeoh Khay Guan , Yan So Jimmy Bok , Huang Zhiwei 
Published: August 2010

AbstractThis study aims to evaluate the clinical utility of image‐guided Raman endoscopy for in vivo diagnosis of neoplastic lesions in the stomach at gastroscopy. A rapid‐acquisition image‐guided Raman endoscopy system with 785‐nm excitation has been developed to acquire in vivo gastric tissue Raman spectra within 0.5 sec during clinical gastroscopic examinations. A total of 1,063 in vivo Raman spectra were acquired from 238 tissue sites of 67 gastric patients, in which 934 Raman spectra were from normal tissue whereas 129 Raman spectra were from neoplastic gastric tissue. The swarm intelligence‐based algorithm (i.e., ant colony optimization (ACO) integrated with linear discriminant analysis (LDA)) was developed for spectral variables selection to identify the biochemical important Raman bands for differentiation between normal and neoplastic gastric tissue. The ACO‐LDA algorithms together with the leave‐one tissue site‐out, cross validation method identified seven diagnostically important Raman bands in the regions of 850–875, 1,090–1,110, 1,120–1,130, 1,170–1,190, 1,320–1,340, 1,655–1,665 and 1,730–1,745 cm−1 related to proteins, nucleic acids and lipids of tissue and provided a diagnostic sensitivity of 94.6% and specificity of 94.6% for distinction of gastric neoplasia. The predictive sensitivity of 89.3% and specificity of 97.8% were also achieved for an independent test validation dataset (20% of total dataset). This work demonstrates for the first time that the real‐time image‐guided Raman endoscopy associated with ACO‐LDA diagnostic algorithms has potential for the noninvasive, in vivo diagnosis and detection of gastric neoplasia during clinical gastroscopy.
IL‐6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines
Authors: Lederle Wiltrud , Depner Sofia , Schnur Sabine , Obermueller Eva , Catone Nicola , Just Alexandra , Fusenig Norbert E. , Mueller Margareta M. 
Published: August 2010

AbstractCytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)‐6 is a key factor by driving tumor progression from benign to malignant, invasive tumors in the HaCaT‐model of human skin carcinoma. IL‐6 activates STAT3 and directly stimulates proliferation and migration of the benign noninvasive HaCaT‐ras A‐5 cells in vitro. Furthermore, IL‐6 induces a complex, reciprocally regulated cytokine network in the tumor cells that includes inflammatory and angiogenic factors such as IL‐8, GM‐CSF, VEGF and MCP‐1. These IL‐6 effects lead to tumor cell invasion in organotypic cultures in vitro and to the formation of malignant and invasive s.c. tumors in vivo. Tumor invasion is supported by the IL‐6 induced overexpression of MMP‐1 in vitro and in vivo. These data demonstrate a key function of IL‐6 in the progression of skin SCCs by regulating a complex cytokine and protease network and suggest new therapeutic approaches to target this central player in skin carcinogenesis.
Degradation of Poly(butyl acrylate) and Poly(2‐hydroxyethyl methacrylate) Model Compounds Under Extreme Environmental Conditions
Authors: Bennet Francesca , Barker Philip J. , Davis Thomas P. , Soeriyadi Alexander H. , Barner‐Kowollik Christopher 
Published: August 2010

AbstractThe degradation of low‐MW ($\overline {M} _{n} $ = 1 500 g · mol−1) model compounds of pBA and pHEMA were studied under conditions corresponding to the worst‐case temperatures and irradiation intensities likely to be experienced by a surface coating exposed to the harsh Australian environment. Vinyl‐terminated polymers were compared to their saturated analogues; the terminal vinyl bond was found to be a source of instability which rendered the polymers more susceptible to degradation. The cyclic degradation mechanism derived from degradation of pMMA in our previous publication is also relevant to pBA and pHEMA. In addition, pBA and pHEMA are susceptible to other degradation and crosslinking reactions; crosslinking is particularly rapid in pHEMA exposed to UV radiation.magnified image
Structure‐based prediction of protein–peptide specificity in rosetta
Authors: King Christopher A. , Bradley Philip 
Published: August 2010

AbstractProtein–peptide interactions mediate many of the connections in intracellular signaling networks. A generalized computational framework for atomically precise modeling of protein–peptide specificity may allow for predicting molecular interactions, anticipating the effects of drugs and genetic mutations, and redesigning molecules for new interactions. We have developed an extensible, general algorithm for structure‐based prediction of protein–peptide specificity as part of the Rosetta molecular modeling package. The algorithm is not restricted to any one peptide‐binding domain family and, at minimum, does not require an experimentally characterized structure of the target protein nor any information about sequence specificity; although known structural data can be incorporated when available to improve performance. We demonstrate substantial success in specificity prediction across a diverse set of peptide‐binding proteins, and show how performance is affected when incorporating varying degrees of input structural data. We also illustrate how structure‐based approaches can provide atomic‐level insight into mechanisms of peptide recognition and can predict the effects of point mutations on peptide specificity. Shortcomings and artifacts of our benchmark predictions are explained and limits on the generality of the method are explored. This work provides a promising foundation upon which further development of completely generalized, de novo prediction of peptide specificity may progress. Proteins 2010. © 2010 Wiley‐Liss, Inc.
DFT calculations for the heterojunction effect between metal clusters and the stabilizer molecules
Authors: Okumura Mitsutaka , Kitagawa Yasutaka , Kawakami Takashi 
Published: August 2010

AbstractLately, liquid phase catalytic reactions over quasi heterogeneous catalysts, whose active site are stabilized by polymers, dendorimers, and soforth, are reported. It is well known that the heterojunction between the metal clusters and the metal oxide supports is important factor for the generation of catalytic activities of the heterogeneous catalysts, such as the metal oxide‐supported Au catalysts. However, there is no metal oxide supports in the quasi heterogeneous catalysts. Therefore, we investigate the difference between the bare cluster and the polymer stabilized clusters using hybrid density functional theory. From the calculation results, it was found that the charge transfer interaction between the stabilizing molecules and the cluster plays an important role to exhibit the catalytic activities of the quasi heterogeneous catalysts. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Kernel energy method: Drug–target interaction energies for drug design
Authors: Huang Lulu , Massa Lou 
Published: August 2010

AbstractThe full power of ab initio quantum mechanics applied to obtain the interaction of drugs and their molecular targets can provide detailed energetics useful to understanding of mechanism and drug design. The computational problem is the growth in quantum computational difficulty with the number of atoms in the molecule. As biochemical molecules are often large, the computational difficulty of the full quantum problem is challenging. Two things help alleviate the difficulty, viz., (1) parallel supercomputers, and (2) quantum crystallography and the use of quantum kernels, a method well suited for parallel computation. Calculations are simplified by approximating a full molecule by smaller “kernels” of atoms. Here, it is suggested that problems of medicinal chemistry, such as the rational design of drugs, may be illuminated by the use of the ab initio quantum‐mechanical kernel energy method. Example calculations within the MP2/3‐21G chemical model are illustrated for three aminoglycoside drugs, which attach to ribosomal A‐site RNA nucleotide targets. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Quantum chemical study of the energetics and directionality of acid‐catalyzed aromatic epoxide ring openings
Authors: Korzan Rory , Upton Brian , Turnbull Kenneth , Seybold Paul G. 
Published: August 2010

AbstractEpoxide ring openings play important roles in a variety of chemical situations and are believed to be important in the metabolic processes through which some polycyclic aromatic hydrocarbons are converted to carcinogenic species. In this report, the energetics and directionalities of acid‐catalyzed epoxide ring openings in benzene and naphthalene are examined using quantum chemical (MNDO/d and MP2/6‐31G*) methods. In particular, the consequences of local saturations in the aromatic systems are examined and shown to exert strong influences on the resulting energetics and product distributions. Partial ring saturation in an aromatic system leads to barrier‐free, spontaneous ring opening of the protonated epoxide in a favored direction and eliminates opening in the opposite direction. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Pathological, immunological and biochemical markers of subchronic arsenic toxicity in rats
Authors: Nain Sukhbir , Smits Judit E. G. 
Published: August 2010

AbstractSubchronic exposure to arsenic in rats was investigated to identify sensitive indicators of subclinical toxicity in rats. Immunological, pathological, and biochemical bioindicators were examined in rats exposed to arsenic in their drinking water. Juvenile male Wistar rats were allocated to four treatment groups receiving 0, 0.4, 4, and 40 ppm of arsenite in drinking water for 18 wks. Besides daily monitoring for clinical signs of adverse health effects, clinical biochemistry, B‐cell‐mediated and innate immune responses, plus gross, and histopathology were examined. In vitro tests of oxidative damage to basic cellular constituents, lipids, proteins, and nucleic acids, were measured using thiobarbituric acid reacting substances (TBARS) assays, protein carbonyl formation, and 8‐hydroxydeoxyguanosine (8‐OHdG), respectively. Clinical changes in the rats were limited to decreased feed and water intake in the high‐ (40 ppm) dose group (P < 0.05), however, growth rate was not affected. Serum biochemical changes occurred in blood urea nitrogen, K+, Cl−, and alanine aminotransferase (ALT) from arsenic exposure. Immunotoxicity was evident through a dose‐dependent suppression of the secondary antibody‐mediated response to a T‐cell‐dependent antigen, keyhole limpet hemocyanin (KLH). Histopathology of the liver revealed marked fatty infiltration and vacuolization particularly evident in periacinar hepatocytes. This pattern of toxicopathology in the high‐exposure group may be related to the significantly higher (P < 0.05) oxidative stress, demonstrated through lipid peroxidation (TBARS assay) in the rats exposed to 40 ppm arsenite. The present study revealed that young, growing rats exposed to arsenic for 18 wks tolerated exposures up to 4 ppm. At higher doses, there was evidence of hepatotoxicity, humoral immunity was compromised, and an adverse effect on hepatic organelle and cell membranes was evident through a dose dependent increased in oxidative stress. © 2010 Wiley Periodicals, Inc. Environ Toxicol, 2012.