bluuebunny/crossref_metadata_2025_split huggingface dataset:
Technology of multilingual skills formation of schoolchildren of the basic comprehensive school in the conditions of an additional modular general educational program “Linguistic Workshop”
Authors: Arakeylyan K. A. , Sorokovykh G. V. 
Published: May 2024

Importance. The problem of the formation of a multilingual student’s personality is important and relevant for modern language education. The purpose of the study is to propose a technology for the formation of multilingual skills of schoolchildren (grades 5-9) based on a modular general development program for the study of languages and cultures in an additional training course.Research Methods. Based on scientific literature theoretical analysis, the refined concept of “modular general educational program of additional education” as a means of multilingual skills forming of schoolchildren is presented. It is proved that a prerequisite for the multilingual skills formation of schoolchildren is their awareness of the value of their multilingual development, upbringing and development of a multilingual personality based on mastering socially significant experience, which is embodied in language knowledge and skills, language and speech activity. The main methods of polylinguistic skills’ formation are: comparative, communicative, method of control and self-control.Results and Discussion. It is revealed and substantiated that the use of a modular general development program in an additional training course will allow developing the student’s multilingual personality, its linguistic thinking, and language ability, which arouses great interest in the didactic possibilities of the proposed technology.Conclusion. The application of the research results can contribute to the development of new directions in linguodidactics and the design of an effective multilingual school environment.
Непараметричний метод оцінки частоти Доплера з урахуванням деформації обвідної й зсуву центральної частоти сигналу спотвореного мультиплікативною завадою
Authors: Костенко Павло Юрійович , Слободянюк Валерій Валерійович 
Published: May 2024

У статті розглянуто непараметричний метод оцінки частоти Доплера широкосмугового сигналу з кодовою (цифровою) маніпуляцією фази, спотвореного мультиплікативною завадою. Оцінка частоти Доплера, яка призводить до деформації обвідної та зсуву несучої частоти, здійснювалась при відсутності апріорної інформації щодо щільності розподілу ймовірностей шумової складової в моделі прийнятого сигналу (спостереженні). Використано припущення, що шумова складова являє собою процес IID (Independent and Identically Distributed) — процес з незалежними та однаково розподіленими випадковими величинами («білий» шум). Запропонована цільова функція (ЦФ), яка для оцінки частоти Доплера використовує BDS-статистику нев’язок, тобто різницю між спостереженням та моделлю очікуваного сигналу. Мінімум ЦФ прийнято за оцінку параметра. Досліджені характеристики якості оцінки частоти Доплера у випадку мультиплікативних завад в спостереженні сигналу з різними розподілами ймовірностей: гаусівським, рівномірним, логістичним та розподілом Коші. Окрема увага приділена випадку, коли щільність розподілу імовірностей мультиплікативної завади характеризується «важкими хвостами». Проведено статистичне моделювання алгоритму оцінки частоти Доплера, що реалізує чисельну мінімізацію запропонованої цільової функції. Показано, що застосування BDS-статистики й запропонованої на її основі ЦФ дозволяє уникнути задання щільності розподілу мультиплікативної завади при визначенні частоти Доплера.
Echoes of Niranj Magic in the Work of Albert the Great
Authors: Rinotas Athanasios 
Published: May 2024

Niranj magic is a genre of magic which is closely connected with a cluster of texts known as Pseudo-Aristotelian Hermetica. As Charles Burnett’s groundbreaking study has shown, a part of these texts has been translated in Latin, albeit not without problems. In fact, the term niranj as such was never translated in Latin and thus tracing the ‘luck’ of this genre of magic in the texts of the Middle Ages is a difficult and arduous task. Despite the aforementioned challenges, this paper aims to show that echoes of niranj magic can be tracked in the work of Albert the Great. In this regard, my study can be deemed as a natural sequel of Burnett’s initial study.
Pola Komunikasi Dakwah Kelompok dalam Grup Regional Komunitas “Ruang Edit”
Authors: Setiawan Veri , Prasidya Zaky Rahman 
Published: May 2024

This research aims to find out how group communication patterns in the regional group of the Ruang Edit community can build member attachment to each other. The method in this research uses a case study qualitative method using B.Aubrey Fisher's Decision Emergence theory and Group Development Bruce Tuckman's approach. The data collection techniques used in this research are non-participant observation in the Jabodetabek and Jateng Regional groups, semi-structured interviews with founders, regional admins, and active members as informants, and documentation taken in the form of photographs of activities and other forms of writing. The result of this study is that each indicator of Decision Emergence theory produces various kinds and forms of communication patterns. The orientation phase uses secondary, one-way, and two-way communication patterns. The conflict phase uses linear and two-way communication patterns. The emergence phase uses circular and two-way communication patterns. The reinforcement phase uses circular, two-way, and multidirectional communication patterns.

Keywords: Da’wah Communication pattern, Community, Ruang Edit
Technology Focus: Intelligent Operations (May 2024)
Authors: Al Yateem Karam 
Published: May 2024

In theory, the term “intelligent operations” could encompass almost the entire spectrum of production operations in the age of the digital oil field. Intelligent technology plays a role in applications ranging from design to completions to data management and most points in between. However, this feature topic is devoted to SPE papers that discuss system-oriented innovations to increase production, reduce costs, and decrease risk. To that end, I’ve identified a trio of papers that highlight such advances.
The first selected paper, SPE 213329, presents a solution that expedites a well-performance-review process to pinpoint candidates for stimulation, nitrogen lift, gas lift conversion, water/gas shutoff, and similar operations. It provides a flexible visualization platform to highlight hidden well-performance insight, prioritizing well-intervention activities.
The next paper, SPE 215236, presents a project designed to establish real applications of artificial intelligence (AI) for waterflood management.
This includes innovations in business processes, application of what the authors call “design thinking” methodology, agile development, and AI. The authors write that their prototype system has increased analytical efficiency, enabled faster decision-making, and improved forecasting.
Paper SPE 215074 describes a project that used a digital twin approach to identify design modifications required at an onshore site and visualize proposed offshore assets in Trinidad and Tobago. The approach integrates existing facilities and new design data, including site surveys and subsurface and wells data to optimize well planning.
I hope you enjoy the work that these authors have presented at SPE conferences.
A Novel Multi-Stage Recursive Image Deraining Network
Authors: wang canhua , Kang Xumin , Xiao Zhiyong , Wu Jianhua 
Published: May 2024

Abstract

The addition of rain stripes will reduce the processing performance of computer vision algorithms with video or images as input, so it is necessary to remove rain stripes from the video or images. A novel multi-stage recursive image deraining network (MRidNet) based on deep learning is proposed in this paper. Considering that rain images contain rain lines of different sizes and directions, encoder-decoder network is used to downsample images at different scales and remove rain lines of different intensities accordingly. In order to enhance the effect of rain removal, a squeeze-and-excitation module is combined to highlight the important feature information. Since the rain grain layer is difficult to be removed at one time, MRidNet adopts the cycle mechanism and uses the long short-term memory network to guide the rain removal before and after the cycle, so as to improve the performance of the model. In general, MRidNet is composed of a repeated expansion of a basic deraining network, which consists of a squeeze-and-excitation module, a long short-term memory module and an encoder-decoder structure. The negative mean structural similarity index is used as the loss function to effectively train the MRidNet. The experimental results show that our proposed MRidNet performs excellently on both synthetic and real rainy images, it can adapt to more complex rain scenes, achieve efficient rain removal, and the restore image background more clearly.
Transcriptomic changes in the posterior pallium of male zebra finches associated with social niche conformance
Authors: Riyahi Sepand , Liebermann-Lilie Navina D. , Jacobs Arne , Korsten Peter , Mayer Uwe , Schmoll Tim 
Published: May 2024

Abstract

Animals plastically adjust their physiological and behavioural phenotypes to conform to their social environment—social niche conformance. The degree of sexual competition is a critical part of the social environment to which animals adjust their phenotypes, but the underlying genetic mechanisms are poorly understood. We conducted a study to investigate how differences in sperm competition risk affect the gene expression profiles of the testes and two brain areas (posterior pallium and optic tectum) in breeding male zebra finches (Taeniopygia castanotis). In this pre-registered study, we investigated a large sample of 59 individual transcriptomes. We compared two experimental groups: males held in single pairs (low sexual competition) versus those held in two pairs (elevated sexual competition) per breeding cage. Using weighted gene co-expression network analysis (WGCNA), we observed significant effects of the social treatment in all three tissues. However, only the treatment effects found in the pallium were confirmed by an additional randomisation test for statistical robustness. Likewise, the differential gene expression analysis revealed treatment effects only in the posterior pallium (ten genes) and optic tectum (six genes). No treatment effects were found in the testis at the single gene level. Thus, our experiments do not provide strong evidence for transcriptomic adjustment specific to manipulated sperm competition risk. However, we did observe transcriptomic adjustments to the manipulated social environment in the posterior pallium. These effects were polygenic rather than based on few individual genes with strong effects. Our findings are discussed in relation to an accompanying paper using the same animals, which reports behavioural results consistent with the results presented here.
Pain in recessive dystrophic epidermolysis bullosa (RDEB): findings of the Prospective Epidermolysis Bullosa Longitudinal Evaluation Study (PEBLES)
Authors: Jeffs Eunice , Pillay Elizabeth , Ledwaba-Chapman Lesedi , Bisquera Alessandra , Robertson Susan , McGrath John , Wang Yanzhong , Martinez Anna , Mellerio Jemima 
Published: May 2024

Abstract

Background
Pain is common in the genetic skin fragility disorder epidermolysis bullosa (EB), from skin and mucosal injury and inflammation as well as extra-mucocutaneous sites. Individuals living with EB have identified pain as a priority for better treatments.
Objectives
The Prospective EB Longitudinal Evaluation Study (PEBLES) is a prospective register study exploring the natural history of RDEB across all ages from birth to death. Here, we investigated the characteristics and treatment of pain in different RDEB subtypes.
Methods
Information was collected from individuals with different RDEB subtypes over an 8-year period. Data included visual analogue scale (VAS) ratings of background and procedural pain, its location, intensity and impact on sleep, as well as pain medication. Disease severity scores and quality of life measures were correlated to pain scores.
Results
Sixty-one participants (13 children, 48 adults) completed a total of 361 reviews. Pain was common, experienced by 93% of participants at index review, with 80% suffering both background and procedural pain. Across all RDEB patients, the median VAS for background pain was 40 (out of 100) [interquartile range 20,60] and for those having regular dressing changes, median procedural pain was 52 [40,80]. Severe (RDEB-S) and pruriginosa (RDEB-Pru) groups had the greatest increase in procedural compared to background pain of 20 and 22 VAS points, respectively. Correlations between disease severity and quality of life impairment were observed across most groups, particularly RDEB-S. Over half of those studied experienced pain frequently or constantly and in one third, pain disturbed sleep at least 4 nights per week. Skin was the commonest source of pain in all subtypes except inversa RDEB where the mouth was the main site. Despite frequent and severe pain, one third of participants used no medication for pain, and in those that did, pain levels remained high, suggesting ineffectiveness of current pain management approaches and a significant unmet need in RDEB.
Conclusion
The frequency, severity, and impact of pain in all RDEB patients is significant, particularly in RDEB-S and RDEB-Pru. Our findings highlight that current RDEB pain management is poorly effective and that further research is needed to address this symptom.
Final Diagnoses and Mortality Rates Among Patients Receiving Inhaled Bronchodilators During Ambulance Transportation
Authors: Hagenau Victor , Mulvad Mathilde Gundgaard , Valentin Jan Brink , Jensen Arne Sylvester Rønde , Gude Martin Faurholdt 
Published: May 2024

Abstract

Objectives: To assess final diagnoses and mortality rates (30-day and 1-year) in patients requiring inhaled bronchodilators administered by ambulance personnel.
Methods: In a retrospective observational cohort study, patients experiencing respiratory distress and treated with inhaled bronchodilators in the prehospital setting within the Central Denmark Region during 2018-2019 were included.
Results: The study included 6,318 ambulance transports, comprising 3,686 cases of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), 234 with community-acquired pneumonia (CAP), 320 with heart disease (HD), 233 adults with asthma, 1,674 with various other primary ICD-10 diagnoses (other ≥18 years), and 171 patients under 18 years. The 30-day mortality rate for all patients was 10.7% (95% CI 9.8-11.6), with zero deaths within 30 days among adults with asthma and those under 18. Excluding low mortality groups, AECOPD patients had the lowest 30-day mortality at 10.2% (95% CI 9.1-11.3), and HD patients the highest at 15.3% (95% CI 10.6-19.9). The 1-year overall mortality rate increased to 32.1% (95% CI 30.2-34.0), with mortality staying low for asthma and under-18 groups, while differences between other groups lessened and became insignificant.
Conclusions: Patients requiring inhaled bronchodilator treatment in ambulances exhibit notably high mortality rates at 30 days and 1 year, except for those with asthma or under 18. The need for prehospital bronchodilators could serve as a clear and unmistakable marker for moderate to severe respiratory distress, enabling early intervention.
Evaluation of preemptive and preventive use of coadministration of ibuprofen L-arginine and dexamethasone on clinical and laboratory parameters, quality of life, pain catastrophizing, and sleep quality in lower third molar surgeries: a randomized, split-mouth, controlled trial
Authors: Cetira-Filho Edson Luiz , Silva Paulo Goberlânio Barros , Maia Isabelle de Fátima Vieira Camelo , Wong Deysi Viviana Tenazoa , Lima-Júnior Roberto César Pereira , Ribeiro Thyciana Rodrigues , Farias Ravy Jucá , Anjos Mayara Alves dos , Fonseca Said Goncalves da Cruz , Costa Fábio Wildson Gurgel 
Published: May 2024

Abstract

Objective
The aim of this study is to compared the effect of different preemptive and preventive analgesia strategies involving the oral coadministration of ibuprofen-arginine (770mg)–Ib-Ar and dexamethasone (8mg)-DX, and their respective placebos (P-Ib-Ar and P-DX), four evaluation groups on inflammatory and laboratory parameters, and impact on quality of life, pain catastrophizing perception and sleep quality related after lower third molar (L3M) surgery.
Material and methods
A randomized split-mouth, triple-blind, controlled clinical trial was conducted with 48 volunteers. They were allocated depending on the use of Ib-Ar or DX, 1 hour before surgery or immediately postoperatively, discriminating the groups: G1 (Ib-Ar + DX), G2 (Ib-Ar + P-DX), G3 (P-Ib-Ar + DX), and G4 (P-Ib-Ar + P-DX).
Results
Pain peaks occurred after 2h (P-Ib-Ar group) (p = 0.003), while the other groups showed peak pain after 4h (p < 0.05). The initial mouth opening amplitude did not differ between groups (p < 0.001). Regarding the edema: groups treated with P-Ib-Ar and the P-DX group; measurements significantly reduced without returning to baseline (p < 0.001). Regarding laboratory parameters: MPO and MDA levels, the Ib-Ar + DX group (p < 0.001) was the only one showing a significant reduction.
Conclusion
The use of preemptive and preventive analgesia strategies involving oral coadministration of Ib-Ar and DX (G1) showed that the combined use delayed peak pain, with no difference in edema and trismus. The benefit of coadministration of both strategies was superior to the isolated use of drugs.
Clinical relevance
Translational study with impact on clinical-surgical protocols involving L3M surgery related to pharmacological methods.
Single-cell immune profiling and validation of PBMCs in the onset of and recovery from herpes zoster
Authors: Xu Longsheng , Zheng Shang , Zhang Shuyao , Li Xiangyao , Fei Yong , Yang Lei , Liu beibei , Shen Kangli , Feng Qinli , Zhou Qinghe , Yao Ming 
Published: May 2024

Abstract

Immune cells play a crucial role in the pathogenesis of herpes zoster virus infection, yet their precise contribution to disease progression remains incompletely understood. In this study, we used single-cell sequencing to analyze the distribution of peripheral blood mononuclear cells (PBMCs) according to different stages of herpes zoster. Our findings demonstrated a detailed immune cell profile in the onset of and recovery from herpes zoster, revealing proportion alterations of the subpopulations. Gene expression information reveals that herpes zoster changes the cellular state compared to healthy controls. The enrichment analysis of cell subpopulations including MPs, B cells, CD8 teff cells and neutrophils revealed changes in signaling responses, transcriptional activity, and cytokine production, exhibiting a heterogeneous immune response to herpes zoster infection. We then surveyed the routine blood data of 1000 patients with herpes zoster, in which the changes in lymphocytes and monocytes were consistent with the single-cell seq results. In addition, the validation of the immune cell clusters distribution using flow cytometry contained 90 samples, we also identified a consistent alteration with single cell-sequencing. These results collectively provide deep insight into the immune profile during herpes zoster progression and provide an indispensable resource for future development of clinical treatment strategy.
Hybrid Epoxy-Acrylate Resins for Wavelength-Selective Multimaterial 3D Printing
Authors: Page Zachariah , Kim Ji-Won , Allen Marshall , Cater Henry , Uddin Ain , Recker Elizabeth , Freeman Benny 
Published: May 2024

Abstract

Structures in nature have evolved to combine hard and soft materials in precise 3D arrangements, which imbues bulk properties and functionality that remain elusive to mimic synthetically. However, the potential for biomimetic analogs to seamlessly interface hard materials with soft surfaces for applications ranging from soft robotics and sealants to medical devices (e.g., prosthetics and wearable health monitors) has driven the demand for innovative chemistries and manufacturing approaches. Herein, we unveil a liquid resin for rapid, high resolution digital light processing (DLP) 3D printing of multimaterial objects with an unprecedented combination of strength, elasticity, and stability. Two enabling discoveries are the use of a covalently bound (hybrid) epoxy-acrylate monomer that precludes plasticization of soft domains and a wavelength-selective photosensitizer that greatly accelerates cationic curing for hard domains. Using dual projection for multicolor (UV and violet light) DLP 3D printing, several bioinspired metamaterial structures are produced, including those with a brick-and-mortar architecture to tune toughness, hard springs in a soft cylinder to tune compressive behavior, and a detailed knee joint with “bones” and “ligaments” to provide smooth motion.
hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic development
Authors: McNeill Rhiannon , Schickardt Zora , Radtke Franziska , Blum Robert , Kittel-Schneider Sarah 
Published: May 2024

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder characterised by inattention, hyperactivity, and impulsivity, significantly impacting life quality and mortality. It is among the most heritable neuropsychiatric disorders, yet its aetiology remains unclear, hindering the development of novel medications. Previously, research has primarily focused on the dopaminergic and noradrenergic systems using animal models. However, there is growing evidence for a role of the glutamatergic system in ADHD pathomechanisms, and a translational failure between pre-clinical animal models and human clinical trials. We therefore established and characterised a functional cortical neuronal model using human induced pluripotent stem cells (hiPSCs) to investigate glutamatergic development in healthy controls and adult ADHD patients. hiPSCs from healthy controls and ADHD patients showed no difference in their capacity to form cortical neurons (CNs). However, CNs from ADHD patients showed an altered developmental trajectory, characterised by changes in extracellular glutamate and decreased transcription of NEUN, PSD95 and EEAT2. Moreover, a significant ~ 50% reduction in vGLUT2 transcription was observed at multiple time points, suggesting a robust cellular disease endophenotype which might be suitable for future drug screening. Lastly, calcium imaging analysis revealed decreased synaptic signalling strength and frequency, indicating a hypoactive phenotype. In summary, we were able to establish a functional hiPSC-derived cortical neuronal model to investigate ADHD pathomechanisms, which revealed impaired glutamatergic development in ADHD individuals. Our results suggest that the glutamatergic system should also be a target for future drug development.