bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcrestal sinus lift using Osseodensification versus lateral window technique with simultaneous implant placement
Authors: Elsaid Mohammed Gamal Abdelftah Hamed , Aboelhasan Mohsen Fawzy , Shuman Mohammad Abd Elhamied , Alashmawy Mohammed Mahgob Mohamed , Ali Hossam Eldin Mohamed , Abdelrahman Ahmed Omar Ahmed , Hassan Mohammed Ali , Elsayed Mohamed Alaa Eldin , Elwaseef Safwat Saber Mohamed Mursey Ali , Mohamed Ahmed Abouelenein Ali 
Published: April 2024

Abstract

Aim
The main objective of this research was to examine the outcomes of transcrestal sinus lift with simultaneous implant placement employing Osseodensification, in comparison to lateral sinus lifting methods. Patients and
Methods
Fourteen patients were enrolled in this clinical trial at the clinic of Oral and Maxillofacial Surgery Department, Faculty of Dental Medicine, Al-Azhar University. These patients were randomized allocated into two groups. Group I: Patients who underwent transcrestal sinus floor elevation procedures utilizing osseodensification. Group II: Patients who received treatment involving Lateral Maxillary Sinus Floor Elevation. CBCT scans were acquired immediately postoperatively and at the 6-month follow-up to assess bone height, bone gain, and bone density. Osstell was utilized to evaluate primary implant stability both during the initial placement and at the six-month follow-up. The length of the surgical procedure was meticulously recorded for every group.
Results
The findings indicated that Group I exhibited a mean bone height gain of 5.33 ± 0.83mm, whereas Group II showed a gain of 10.02 ± 1.82mm, with a significant statistical difference. The average implant stability quotient (ISQ) values for Group I was 80.00 ± 3.11, compared to 75.86 ± 2.91 for Group II, also showing a statistically significant difference.
Conclusion
Crestal maxillary sinus elevation with Osseodensification shows better bone density and implant stability than lateral lifting. Osseodensification is less invasive and time-consuming, making it a potential alternative to the lateral window technique.
Systemic inflammatory response syndrome after on-pump cardiac surgery in emergency coronary artery bypass grafting: a retrospective trial
Authors: Krichevskiy Lev А. , Dvoryadkin А. А. , Polyakov D. A. , Belyakova E. V. , Protsenko D. N. 
Published: April 2024

INTRODUCTION: The frequency, spectrum and pathophysiological relationships of systemic inflammatory response syndrome in acute coronary artery bypass grafting is not fully understood. OBJECTIVE: To determine the clinical significance of systemic inflammatory response syndrome (SIRS) in emergency coronary artery bypass grafting (CABG) performed with cardiopulmonary bypass. MATERIALS AND METHODS: We examined 60 patients (38 men and 22 women, aged 65 ± 9 years) who underwent emergency CABG (3 ± 1 bypass), with cardiopulmonary bypass (CPB) (97 ± 47 min). We retrospectively studied clinical and laboratory data of the perioperative and early postoperative period from emergency and elective coronary bypass surgery. RESULTS: In urgently operated patients (n = 30) in the early postoperative period, a higher frequency (53.3 and 13.3 %; p = 0.0022) of the development of systemic manifestations of the inflammatory response (neutrophilic leukocytosis, fever, postperfusion vasoplegia), as well as respiratory complications (70 and 10 %; p < 0.001) was noted. A pathophysiological relationship was established between the manifestations of SIRS and respiratory dysfunction during emergency interventions. CONCLUSIONS: SIRS pathophysiologically associated with respiratory dysfunction is characteristic of emergency CABG. It is during emergency myocardial revascularization that the duration of cardiopulmonary bypass and myocardial ischemia (MI) are predictors of SIRS.
Some features of the perioperative management of patients with a tumor of the chiasmal cellaric region: a review
Authors: Tsentsiper Lyubov M. , Petrova A. O. , Terekhov I. S. , Leyderman I. N. , Gulyaev D. A. , Ulitin A. Yu. , Samochernykh K. A. , Kondratyev A. N. 
Published: April 2024

INTRODUCTION: Tumors of the chiasmal-sellar region (CSR) account for more than 20 % of all primary intracranial neoplasms, of which pituitary adenomas account for up to 20 % of the world population. Currently, removal of these neoplasms is performed using endoscopic transsphenoidal surgical accesses. OBJECTIVE: analysis of the results of publications concerning perioperative management of patients with CSO tumors. MATERIAL AND METHODS: publications were searched and selected in bibliographic databases PubMed, Web of Science, Scopus. To study the approach to perioperative management of patients with CSF tumors, the works published from 2013 to 2023 were analyzed. Search keywords: pituitary surgery, anesthesia. Based on the analysis of current problems in anesthesia planning for patients with CSF tumors, the search was expanded with additional keywords: “pituitary tumor”, “perioperative complications”, “endocrine disorders”, “difficult airway”, “acromegaly”, “cardiologic complications, acromegaly”, “peripheral neuropathy, acromegaly”, “trigemino-cardiac reflex”, 206 publications were additionally analyzed and the main key points in anesthesia planning were summarized. A total of 230 publications were included but 161 were excluded. A total of 69 studies were selected. RESULTS: The main features of patients with CSF tumors are: water-electrolyte disorders, cardiovascular pathology, difficult airway. This determines a multidisciplinary approach in preparation for surgery. It is necessary to take into account these features when planning anesthetic support and management of the early postoperative period. In addition, endoscopic transnasal-transsphenoidal access may cause a number of complications: damage to the hypothalamic region and large vessels, and in the postoperative period: respiratory disorders, hormonal insufficiency, Water and Sodium Disturbances. CONCLUSIONS: Additional vigilance is required when preparing a patient with CSF formation for surgery. Perioperative management of a patient with CSO tumor requires a team approach with participation of neurosurgeons, neurologists, ophthalmologists, endocrinologists, cardiologists, anesthesiologists-resuscitators.
Predictors for negative clinical outcome in acute mesenteric ischemia after on-pump cardiac surgery: a retrospective observational trial
Authors: Ponomareva A. D. , Leyderman Ilya N. , Kasherininov I. Y. , Danilov I. N. 
Published: April 2024

INTRODUCTION: Acute mesenteric ischemia (AMI) is one of the most dangerous complications of cardiac surgery using cardiopulmonary bypass (CPB). Several factors may contribute to the development of AMI, such as: age over 70 years, prolonged CBP, postoperative heart failure, cardiogenic shock, mechanical circulatory support and others. The mortality rate in AMI reaches 85 %. OBJECTIVE: To identify predictors of a negative clinical outcome in the development of acute mesenteric ischemia in patients after on-pump cardiac surgery. MATERIALS AND METHODS: A single-center retrospective observational cohort study included 53 patients in the intensive care unit who developed AMI after cardiac surgery performed using CPB. All patients with AMI included in the study were divided into two groups — survivors (n = 31) and non- survivors (n = 22) to identify predictors of negative clinical outcome. RESULTS: At the preoperative stage, the left ventricular ejection fraction (LVEF) was impaired in both groups, but in non-survived patients was significantly lower: 34.6 (25.4–52.4) in survivors and 28.7 (25.2–42.7) in non-survivors (p = 0.05). 12 hours after the surgery, the cardiac index (CI) (p = 0.01) and the index of left ventricular work (ILVW) were significantly (p = 0.03) lower in non-survivors. The average duration of CPB was 124 minutes (95–142) in survivors and 164 minutes in non-survivors (145–176) (p = 0.02). Also, 72.7 % of n0n-survivers received high doses of adrenomimetics in the postoperative period, in survivors — 41.9 % (p = 0.03). The rate of long-term mechanical respiratory support usage in non-survivors reached 86.3 %, in survivors — 35.4 % (p = 0.003). CONCLUSIONS: The key predictors of a negative outcome of OMI in cardiac surgery patients are: prolonged use of CBP, low CI, LVWI before and after surgery, high doses of adrenomimetics, prolonged mechanical respiratory support, as well as high concentrations of blood lactate 12 hours after the end of the surgery.
Predicting an unfavorable outcome in patients with liver failure associated with obstructive jaundice syndrome: a prospective observational study
Authors: Petrova Marina V. , Mamoshina I. V. 
Published: April 2024

INTRODUCTION: Specialized scales developed to assess survival and mortality of patients after liver transplantation have not been validated when applied to liver failure in the setting of obstructive jaundice. OBJECTIVE: To determine the prognostic value of multiparametric scoring scales and to identify predictors of unfavorable outcome in liver failure due to obstructive jaundice. MATERIALS AND METHODS: 53 patients with confirmed liver failure due to obstructive jaundice of benign etiology who underwent biliary decompression were included in this prospective, observational, single-center study. Depending on the outcome two groups were distinguished: with favorable (n = 27, 51 %) and with unfavorable outcome (n = 26, 49 %). The following time points were defined for the dynamic evaluation of the course of the disease: day 1, day 3, day 7, and day 11 after decompression. Statistical processing of the data was performed using IBM SPSS Statistics 22 software for social science data analysis. RESULTS: The sensitivity and specificity of the studied scales in predicting liver failure due to obstructive jaundice were calculated on the basis of receiver operating characteristic (ROC) analysis. The AUROC for the SOFA was 0.862, for the MELD — 0.882, for the APACHE II — 0.864, for the Child-Turcotte-Pugh — 0.813. The sensitivity and specificity values for the SOFA were 78.9 and 77.8 %, for the MELD — 80.8 and 79.7 %, for the APACHE II — 57.7 and 81.9 %, and for the Child-Turcotte-Pugh — 75.1 and 70.9 %, respectively. Albumin was an independent predictor of unfavorable outcome (AUC ROC 0.909, p = 0.01), sensitivity 88.6 %, specificity 85.2 %. CONCLUSIONS: The scales presented in the study and the biomarker candidate “albumin” showed significant prognostic ability, but low values of sensitivity and specificity (less than 80 %) in some points of the study require the search for additional predictors of unfavorable outcome of liver failure due to obstructive jaundice.
Video velocity measurement: A two-stage flow velocity prediction method based on deep learning
Authors: Wang Xiaolong , Ma Qiang , Wang Genyi , An Guocheng 
Published: April 2024

ABSTRACT
Due to the uncertainty in output caused by environmental changes, significant discrepancies are expected between the surface flow velocities predicted using deep learning methods and the instantaneous flow velocities. In this paper, a two-stage deep learning flow velocity measurement algorithm is proposed. During the external calibration process, the upper and lower frames of the recorded water flow video are cyclically traversed to acquire predicted flow velocity values using the deep learning velocity measurement algorithm. Meanwhile, the pixel displacement is obtained using the sparse optical flow tracking method and then post-processed to derive the velocity calibration value and pixel calibration value. During the detection process, the deep learning-predicted flow velocity is internally calibrated using the velocity calibration value and the pixel calibration value to adapt to changes in water flows. Compared with the pre-improved algorithm, the method achieves the minimum root mean square error in five different flow velocity videos and maintains high accuracy when the flow velocity changes rapidly. The obtained results are very promising and can help improve the reliability of video flow rate assessment algorithms.
Impact of the comprehensive remediation project on hydrological conditions in the lower reaches of the Ganjiang River
Authors: Lu Jiangang , Fu Yanmei , Li Xuefei , Zhou Yuan , Zhang Liwei 
Published: April 2024

ABSTRACT

This study undertakes a systematic analysis of the hydrological changes before and after the implementation of the Comprehensive Remediation Project in the lower reaches of the Ganjiang River. It focuses on changes in downstream inflow, ratios of flow distribution, and water levels, as well as water velocity near the gates. The results indicate a significant improvement in the spatial distribution of water resources in the lower reaches of the Ganjiang River. The project enhances the inflow from the northern and southern branches, positively influencing downstream water usage and the ecological environment. Building upon these findings, the study proposes operational recommendations tailored to different hydrological years, such as timely adjustments to the southern branch's water inflow and optimizing flow distribution ratios. This research provides a scientific basis for the implementation and dispatch of comprehensive remediation projects and offers insights into water resource management in similar regions.
Molecular Pathways and Treatment Updates on Huntington’s Disease with
Special Preference to Juvenile Phase: A Comprehensive Review
Authors: Suryavanshi Kunal , Sharma Anuj Kumar , Murti Yogesh , Kumari Vibha , Shanker Shukla Karuna , Kulshreshtha Mayank 
Published: April 2024

Abstract::
A degenerative brain ailment called Huntington's disease (HTD) causes irritable behavior, emotional distress, cognition, etc. It is also known as
Huntington's chorea. Compared to men, women are more likely to get HTD. However, in India, if 3 to 5% of Europeans are affected, it is difficult
to estimate the disease's prevalence. The full pathophysiological status, several molecular pathways, and pharmaceutical and non-pharmacological
treatments for Huntington's disease are covered in this article. Google, PubMed, Scopus, Bentham, Elsevier, and other significant web resources
were used to gather the scientific data. Moreover, this review article may serve as the foundation for future study, particularly on Huntington's
illness.
Exploring Phytotherapy's Preventive and Therapeutic Impact on Global
COVID-19 Management: A Narrative Review
Authors: Parchami Ghazaee Sepideh , Sereda Petro , Marchenko-Tolsta Kateryna , Hameed Murtaza 
Published: April 2024

Introduction::
The WHO Emergency Committee advocates preventive strategies for COVID-19 management, emphasising vaccines as highly effective but
acknowledging their limitations. Chloroquine and hydroxychloroquine, initially effective against COVID-19, were discontinued due to severe side
effects. Further clinical trials are imperative to establish the safety and efficacy of new antiviral agents, some of which may have harmful effects on
human development.

Objectives::
The shortcomings of various conventional treatments have prompted urgent efforts to discover safe, natural compounds that may be useful in
combating COVID-19. This study aims to review research that has investigated the potential of traditional phytotherapies used by different
populations for the prevention and symptomatic treatment of COVID-19 infection.

Methods::
This paper reviewed scientific studies published through searching on search engines such as PubMed, Scopus, Google Scholar, ScienceDirect and
Elsevier from May until October 2023.

Results::
The preventive and anti-COVID-19 attributes of Traditional Chinese Medicine, Ayurvedic formulations and African medicinal plants have been
substantiated in research. In Nepal, recommendations endorse the utilisation of medicinal plants for herbal teas and homemade sanitizers. Zingiber
officinale, Curcuma longa L. and Curcuma xanthorriza Roxb., along with Camellia sinensis are crucial Indonesian medicinal plants with potential
for treating COVID-19. Z. officinale was predominantly chosen for relieving coughs and sore throats associated with COVID-19 in Saudi Arabia.

Discussion::
The immunomodulatory properties of medicinal plants, which may prove useful in combating COVID-19, have been verified via elevation of the
level of peripheral WBCs, IgM, IgG; inhibition of leukotrienes and prostaglandins, maintenance of the integrity of intestinal mucosal barrier and
regulation of HMGB1. The antiviral effects of herbs, including the inhibition of viral DNA and RNA replication, down-regulation of oxidative
stress, and the impediment of SARS-CoV-2 access to vascular endothelial cells, suggest their potential to facilitate earlier recovery from
COVID-19 infection.

Conclusion::
Advancing scientific research in phytotherapy promises the possibility of novel approaches for effectively managing future infectious diseases and
pandemics.
Impact of Combination Therapy with Chemical Drugs and Megavoltage X-ray
Exposure on Breast Cancer Stem Cells’ Viability and Proliferation of MCF-7
and MDA-MB-231 Cell Lines
Authors: Banisharif Dehkordi Fatemeh , Ghatrehsamani Mahdi , Abdolvand Maryam , Soltani Amin , Masoumi Seyed Hossein 
Published: April 2024

Background::
Breast Cancer (BC) is a serious malignancy among women. However, chemotherapy
is an important tool for cancer treatments, but the long-term use of chemotherapy drugs may lead to drug resistance
and tumor recurrence. Since Breast Cancer Stem Cells (BCSCs) can be the main factor to induce BC
treatment resistance and recurrence, investigation of BCSCs signaling pathways can be an effective modality
to enhance cancer treatment efficiency.

Objective::
In this study, the effect of metformin, SB203580, and takinib alone or in combination with radiotherapy
on MCF-7 and MDA-MB-231 breast cancer cell lines was evaluated.

Methods::
MCF-7 and MDA-MB-231 breast cancer cell lines were treated with metformin, SB203580, and
takinib for 24 or 48 hours, followed by X-ray exposure. The MTT assay and flow cytometry analysis were performed
to assess cell growth inhibition and cellular death, CXCr4 expression, and BCSCs, respectively.

Results::
The results showed the combination of takinib/SB203580 with radiotherapy to remarkably reduce the
CXCR4 expression and BCSCs levels in the MCF-7 cell line. Also, the concurrent administration of
takinib/metformin/radiotherapy significantly reduced BCSCs and CXCR4 metastatic markers in the MDA-MB-
231 cells. Since the MAPK signaling pathway has an important role in inducing drug resistance and cell proliferation,
the use of SB203580 as an inhibitor of p38 MAPK can improve breast cancer treatment. Furthermore,
metformin and ionizing radiation by suppression of the mTOR signaling pathway can control AMPK activation
and cellular proliferation.

Conclusion::
Anti-cancer and cytotoxic effects of metformin can be effective in this strategy. In conclusion,
the combination of conventional chemotherapeutic drugs, including SB203580, metformin, and takinib with
X-ray exposure can be a new approach to diminish the drug resistance of breast cancer.
Uncovering the Role of Anmeidan against Atherosclerosis from Integrated Network Pharmacology and Pharmacological Experiments
Authors: Zheng Yuting , Wang Jianxiang , Pan Chengcheng , Song Jihong , Li Xingyue , Ta Wenjing , Lu Wen 
Published: April 2024

Background:
Atherosclerosis (AS) is the leading cause of mortality in elderly individuals
worldwide. Anmeidan (AMD) is a Traditional Chinese Medicine (TCM) formula composed
of many herbs, many of which have been accepted for treating AS. This study aimed to
explore whether AMD can inhibit the progress of AS and its possible mechanism.

background:
Atherosclerosis (AS) is the leading cause of mortality in elderly individuals worldwide. Anmeidan (AMD) is a traditional Chinese medicine (TCM) formula composed of many herbs that have been accepted for treating AS.

Methods:
ApoE-/- mice were used to establish the AS model and evaluate the therapeutic effect
of AMD on AS. Based on network pharmacology technology, the potential mechanism of
AMD for treating AS was explored, and lipid metabolism pathways related to AS were mainly
studied. Next, the effects of AMD on liver lipid levels, antioxidant capacity, liver tissue morphology,
and gene expression related to lipid metabolism in ApoE-/- mice were investigated.
Cellular experiments were performed to confirm the lipid-lowering effect of AMD. Finally, the
AMD composition was determined using liquid chromatography-tandem mass spectrometry
(LC-MS/MS).

Results:
In ApoE-/- mice, AMD effectively alleviated AS by reducing serum total cholesterol,
triglyceride, low-density lipoprotein levels, and plaque area, and increasing high-density lipoprotein
levels. Network pharmacology indicated that AMD may suppress AS by regulating lipid
metabolism pathways with multiple TCM components, which is consistent with the results
of in vivo experiments and LC-MS/MS component identification. AMD significantly reduced
liver lipid aggregation, intensified antioxidant enzyme activity, and upregulated the mRNA
levels of ABCA1, ABCG1, and LDLR with increased cholesterol efflux. In addition, AMD decreased
cholesterol levels in foam cells.

Conclusions:
This study confirmed that AMD could treat AS by regulating lipid metabolism
and preliminarily explored the related mechanism. These findings provide new ideas for the
treatment of AS with TCM.

result:
In ApoE-/- mice, AMD effectively alleviated AS by reducing serum total cholesterol, triglyceride, low-density lipoprotein levels, and plaque area, and increasing high-density lipoprotein levels. Network pharmacology indicated that AMD may suppress AS by regulating cholesterol metabolism pathways through multicomponent, which is consistent with the results of in vivo experiments and LC–MS/MS component identification. AMD significantly reduced liver lipid aggregation, intensified antioxidant enzyme activity, and upregulated the mRNA levels of ABCA1, ABCG1, and LDLR with increased cholesterol efflux. In addition, AMD decreased cholesterol levels in foam cells.

other:
none