bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results From a Pivotal, Open-Label, Phase II Study of Romidepsin in Relapsed or Refractory Peripheral T-Cell Lymphoma After Prior Systemic Therapy
Authors: Coiffier Bertrand , Pro Barbara , Prince H. Miles , Foss Francine , Sokol Lubomir , Greenwood Matthew , Caballero Dolores , Borchmann Peter , Morschhauser Franck , Wilhelm Martin , Pinter-Brown Lauren , Padmanabhan Swaminathan , Shustov Andrei , Nichols Jean , Carroll Susan , Balser John , Balser Barbara , Horwitz Steven 
Published: January 2012

Purpose Romidepsin is a structurally unique, potent class 1 selective histone deacetylase inhibitor. The primary objective of this international, pivotal, single-arm, phase II trial was to confirm the efficacy of romidepsin in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). Patients and Methods Patients who were refractory to at least one prior systemic therapy or for whom at least one prior systemic therapy failed received romidepsin at 14 mg/m2 as a 4-hour intravenous infusion on days 1, 8, and 15 every 28 days. The primary end point was the rate of complete response/unconfirmed complete response (CR/CRu) as assessed by an independent review committee. Results Of the 131 patients enrolled, 130 had histologically confirmed PTCL by central review. The median number of prior systemic therapies was two (range, one to eight). The objective response rate was 25% (33 of 130), including 15% (19 of 130) with CR/CRu. Patient characteristics, prior stem-cell transplantation, number or type of prior therapies, or response to last prior therapy did not have an impact on response rate. The median duration of response was 17 months, with the longest response ongoing at 34+ months. Of the 19 patients who achieved CR/CRu, 17 (89%) had not experienced disease progression at a median follow-up of 13.4 months. The most common grade ≥ 3 adverse events were thrombocytopenia (24%), neutropenia (20%), and infections (all types, 19%). Conclusion Single-agent romidepsin induced complete and durable responses with manageable toxicity in patients with relapsed or refractory PTCL across all major PTCL subtypes, regardless of the number or type of prior therapies. Results led to US Food and Drug Administration approval of romidepsin in this indication.
Why UK-trained doctors leave the UK: cross-sectional survey of doctors in New Zealand
Authors: Sharma Avinash , Lambert Trevor W , Goldacre Michael J 
Published: January 2012

Objectives To investigate factors which influenced UK-trained doctors to emigrate to New Zealand and factors which might encourage them to return. Design Cross-sectional postal and Internet questionnaire survey. Setting Participants in New Zealand; investigators in UK. Participants UK-trained doctors from 10 graduation-year cohorts who were registered with the New Zealand Medical Council in 2009. Main outcome measures Reasons for emigration; job satisfaction; satisfaction with leisure time; intentions to stay in New Zealand; changes to the UK NHS which might increase the likelihood of return. Results Of 38,821 UK-trained doctors in the cohorts, 535 (1.4%) were registered to practise in New Zealand. We traced 419, of whom 282 (67%) replied to our questionnaire. Only 30% had originally intended to emigrate permanently, but 89% now intended to stay. Sixty-nine percent had moved to take up a medical job. Seventy percent gave additional reasons for relocating to New Zealand including better lifestyle, to be with family, travel/working holiday, or disillusionment with the NHS. Respondents' mean job satisfaction score was 8.1 (95% CI 7.9–8.2) on a scale from 1 (lowest satisfaction) to 10 (highest), compared with 7.1 (7.1–7.2) for contemporaries in the UK NHS. Scored similarly, mean satisfaction with the time available for leisure was 7.8 (7.6–8.0) for the doctors in New Zealand, compared with 5.7 (5.6–5.7) for the NHS doctors. Although few respondents wanted to return to the UK, some stated that the likelihood of doctors' returning would be increased by changes to NHS working conditions and by administrative changes to ease the process. Conclusions Emigrant doctors in New Zealand had higher job satisfaction than their UK-based contemporaries, and few wanted to return. The predominant reason for staying in New Zealand was a preference for the lifestyle there.
Synthesis, crystal structure and optical properties of the
catena
-metaphosphates Ce(PO3)4 and U(PO3)4
Authors: Höppe Henning A. , Daub Michi 
Published: January 2012

Abstract
The catena-metaphosphates of tetravalent cerium and tetravalent uranium were obtained as phase pure crystalline powders by reaction of the respective dioxides with phosphoric acid at 500 °C. Ce(PO3)4 and U(PO3)4 crystallise in space group C2/c (Z = 16, a
Ce = 13.7696(3) Å, b
Ce = 29.7120(7) Å, c
Ce = 8.9269(2) Å, β
Ce = 90.00(1) Å3 and a
U = 13.786(3) Å, b
U = 29.843(6) Å, c
U = 8.9720(18) Å, β
U = 90.01(3) Å3). The vibrational and optical spectra of pale yellow Ce(PO3)4 and emerald-greenish U(PO3)4 are also reported.
Prospective Study of Sunburn and Sun Behavior Patterns During Adolescence
Authors: Dusza Stephen W. , Halpern Allan C. , Satagopan Jaya M. , Oliveria Susan A. , Weinstock Martin A. , Scope Alon , Berwick Marianne , Geller Alan C. 
Published: January 2012

OBJECTIVES:
Early childhood UV light radiation (UVR) exposures have been shown to be associated with melanoma development later in life. The objective of this study was to assess sunburn and changes in sunburn and sun behaviors during periadolescence.

METHODS:
A prospective, population-based study was conducted in fifth-grade children (∼10 years of age) from Framingham, Massachusetts. Surveys were administered at baseline (September–October 2004) and again 3 years later (September–October 2007). Surveys were analyzed to assess prevalence of reported sunburn and sun behaviors and to examine changes in response over the follow-up period.

RESULTS:
Data were analyzed from 360 participants who had complete information regarding sunburn at both time points. In 2004, ∼53% of the students reported having at least 1 sunburn during the previous summer, and this proportion did not significantly change by 2007 (55%, P = .79), whereas liking a tan and spending time outside to get a tan significantly increased (P &lt; .001). In 2004, 50% of students reported “often or always” use of sunscreen when outside for at least 6 hours in the summer; this proportion dropped to 25% at the follow-up evaluation (P &lt; .001).

CONCLUSIONS:
With at least 50% of children experiencing sunburns before age 11 and again 3 years later, targeting children in pediatric offices and community settings regarding unprotected UV exposure may be a practical approach. Because periadolescence is a time of volatility with regard to sun behaviors, learning more about children who receive sunburns versus those who avoid them is a critical research task.
Incidence and Timing of Presentation of Necrotizing Enterocolitis in Preterm Infants
Authors: Yee Wendy H. , Soraisham Amuchou Singh , Shah Vibhuti S. , Aziz Khalid , Yoon Woojin , Lee Shoo K. ,   the Canadian Neonatal Network
Published: January 2012

OBJECTIVES:To examine the variation in the incidence and to identify the timing of the presentation of necrotizing enterocolitis (NEC) in a cohort of preterm infants within the Canadian Neonatal Network (CNN).METHODS:This was a population-based cohort of 16 669 infants with gestational age (GA) &lt;33 weeks, admitted to 25 NICUs participating in the CNN between January 1, 2003, and December 31, 2008. Variations in NEC incidence among the participating NICUs for the study period were examined. We categorized early-onset NEC as occurring at &lt;14 days of age and late-onset NEC occurring at ≥14 days. Multivariate logistic regression analysis was performed to identify risk factors for early-onset NEC.RESULTS:The overall incidence of NEC was 5.1%, with significant variation in the risk adjusted incidence among the participating NICUs in the CNN. Early-onset NEC occurred at a mean of 7 days compared with 32 days for late-onset NEC. Early-onset NEC infants had lower incidence of respiratory distress syndrome, patent ductus treated with indomethacin, less use of postnatal steroids, and shorter duration of ventilation days. Multivariate logistic regression analysis identified that greater GA and vaginal delivery were associated with increased risk of early-onset NEC.CONCLUSIONS:Among infants &lt;33 weeks’ gestation, NEC appears to present at mean age of 7 days in more mature infants, whereas onset of NEC is delayed to 32 days of age in smaller, lower GA infants. Further studies are required to understand the etiology of this disease process.
Mid-Infrared Lead-Salt Surface Emitting Photonic Crystal Laser on Silicon
Authors: Weng Binbin , Li Lin , Qiu Jijun , Shi Zhisheng 
Published: January 2012

ABSTRACTThe lead-salt epitaxial membrane embedded with two dimensional hexagonal air holes lattice array was used to develop the mid-infrared (mid-IR) photonic crystal surface emitting laser. For the initial proof-of-concept research work, we demonstrated intensive photonic crystal coupled mid-IR vertical light emissions from the designed structure under cryogenic temperature range. In order to realize room temperature operation, we modified the photonic bands structure, aligned the photonic crystal coupled mode with the gain spectrum of active material at 300 K. As a result, under pulsed mode optical excitation, multi-mode room temperature mid-IR photonic crystal lasing emissions were achieved at wavelength ∼3.5 μm recently. With further optimization, a practical lead-salt continuous-wave operating room temperature surface emitting photonic crystal laser is anticipated soon, and this will explore promising applications in a wide variety of fields.
Thin Film Formation of Transparent Conductive Oxides by Solution-Based Mist Deposition Method toward Hybrid Device Applications
Authors: Ikenoue Takumi , Fujita Shizuo 
Published: January 2012

ABSTRACTTransparent conductive oxides, gallium-doped zinc oxide (ZnO:Ga) and tin-doped indium oxide (ITO), were fabricated by a solution-based ultrasonic spray-assisted mist deposition technique. The ZnO:Ga films showed a good c-axis orientation perpendicular to the substrate and achieved low resistivity of 2.3 × 10-3 Ω cm with high transmittance in wide wavelength region. ITO films have lower resistivity of 1.4 × 10-4 Ω cm and high transmittance over the wavelength of 300 nm.
Synthesis of copper nanoparticles by polyol/alcohol reduction method
Authors: Cuya Huaman Jhon L. , Sato Kimitaka , Kurita Satoru , Matsumoto Takatoshi , Miyamura Hiroshi , Balachandran Jeyadevan 
Published: January 2012

ABSTRACTOleylamine stabilized copper nanoparticles with an average diameter of ~10 nm were obtained by reducing copper chloride with 1-heptanol. Surfactants such as oleylamine, poly (N-vinylpyrrolidone) and oleic acid were used to avoid the agglomeration and growth of the particles during the synthesis and consequent dispersion in organic solvent. The analyses of the samples indicated that oleylamine results to be more suitable to prepare stable copper suspensions in dodecane. The electrical resistivity of the copper thin films prepared by spin coating the copper nanoink and annealed at 250 °C under different atmospheres was less than 35 μΩ-cm, which is closer to the values reported for Cu nanoparticles.
Computer-assisted designing and biofabrication of 3-D hydrogel structures towards thick 3-D tissue engineering
Authors: Nakamura Makoto , Arai Kenichi , Toda Hideki , Iwanaga Shintaroh , Ito Kozo , Genci Capi , Nikaido Toshio 
Published: January 2012

ABSTRACTEngineering and manufacturing of thick and bio-functional tissue products is one of the big issues in tissue engineering. To produce such tissues, we need some innovative technologies, which enable us to build up thick, three-dimensional structures and to arrange multiple types of cells to make complicated tissue structures. Based on such considerations, we have developed a custom-made inkjet 3D bioprinter, which realized both of direct cell printing and 3D laminating printing with cells and hydrogel. Recently, it has been improved, and here we report recent progresses and our achievements with new version 3D bioprinter.Image based printing mode and active Z-axis control system were added. As a useful structure, an image of multi-honeycomb pattern was designed in computer and next it was copied and finally in total 100 image data were prepared. Using those digital data, 3D image of thick multi-honeycomb structure was reconstructed in computer, and then, laminating printing was carried out using our new version 3D bioprinter with alginate hydrogel. The new version printer showed good performance of 3D laminating printing and finally complicated 3D multi-honeycomb hydrogel structures could be successfully fabricated. It is indicated that fabrication of cell containing 3D structures based on the computer aided designs is feasible and that such biofabrication technologies must contribute to further innovative advancement of tissue engineering.
Smart Surfaces: Use of Electrokinetics for Selective Modulation of Biomolecular Affinities
Authors: Emaminejad Sam , Javanmard Mehdi , Dutton Robert W. , Davis Ronald W. 
Published: January 2012

ABSTRACTWith the aid of negative dielectrophoresis (nDEP) force in conjunction with shear force and at an optimal sodium hydroxide (NaOH) concentration we demonstrated a switch-like functionality to elute immuno-bound beads from the surface. At an optimal flow rate and NaOH concentration, nDEP turned on results in bead detachment, whereas when nDEP is off, the beads remain attached. This platform offers the potential for performing a bead-based multiplexed immunoassay where in a single channel various regions are immobilized with a different antibody, each targeting a different antigen. As a proof of concept we demonstrated the ability of nDEP to provide this switching behavior in a singleplex assay for the interactions that were in the same order of magnitude in strength as typical antibody-antigen interactions.
Opinions of School Managers about Chosen Problems of Physical Education
Authors: Dančíková Veronika , Antala Branislav 
Published: January 2012

Opinions of School Managers about Chosen Problems of Physical Education
School managers consider physical education mostly as an important subject. Those managers, who are engaged in sport, have closer relation to this subject, which resulted in more positive answers about satisfaction with teachers of physical education, or in opinion, that physical education is as important subject as any other in school. Therefore we recommend to teachers of physical education who are engaged in sport to be more involved in managerial posts. The schools will have better conditions for education, also the quality of physical education will improve and motivation of student to be actively engaged in subject and support of physical education will increase.
The Value of Reflective Practice in Professional Development: An Applied Sport Psychology Review
Authors: Cropley Brendan , Hanton Sheldon , Miles Andy , Niven Ailsa 
Published: January 2012

The Value of Reflective Practice in Professional Development: An Applied Sport Psychology Review
The purpose of this review is to situate the concept of reflective practice within the professional training and development of applied sport psychology (ASP) practitioners. In particular, to consider the progression of the field of ASP into professional status and examine the potential value of reflective practice as a mechanism to assist practitioners develop their effectiveness. The review initially outlines recent developments in professional training and development within ASP in order to frame the current environment in which neophyte consultants are trained and professional practitioners work before progressing to consider reflective practice, its definitions and relationship with experiential learning and professional practice. The use of reflective practice within sport psychology is then considered, with the final section of the review focusing on potential limitations of the available sport psychology literature and thus the rationale for further investigation.
Correlations of Handgrip Strength and some Anthropometric Variables in Indian Inter-University Female Handball Players
Authors: Koley Shyamal , Kaur Satinder , Sandhu Jaspal 
Published: January 2012

Correlations of Handgrip Strength and some Anthropometric Variables in Indian Inter-University Female Handball Players
The purpose of this study was of two-folds, firstly, to evaluate the handgrip strength and some anthropometric characteristics of Indian inter-university female handball players and, secondly, to search the correlations of these physical traits among themselves. To serve this purpose, thirteen anthropometric characteristics, were measured on purposely selected 101 Indian inter-university female handball players aged 18-25 years (mean age 20.13 years, ±1.40) collected from seven Indian universities and the competition was held in Guru Nanak Dev University, Amritsar, India. An adequate number of controls (n = 100, 21.10 years, ± 1.70) were also collected from the same place. The results indicated statistically significant differences (p<.05-.001) in all the variables, except BMI, right upper arm and forearm lengths, right upper extremity length and right upper arm circumference between Indian inter-university female handball players and controls. Dominant right handgrip strength has significantly positive correlations (p≤.01) with all the variables, except left hand width and right upper extremity length. Height and weight have significantly positive correlations (p≤ .01) with all the variables, except right upper extremity length and right upper arm circumference. For rest of the anthropometric variables, it was observed that almost all the variables were correlated to each other significantly (p≤ .05 - .01) with positive correlations, except right upper extremity length and right upper arm circumference.
Resiliency, Control, Enjoyment and Physical Activity in African American High School Students
Authors: Martin Jeffrey , McCaughtry Nate , Shen Bo , Fahlman Mariane , Garn Alex , Ferry Matt 
Published: January 2012

Resiliency, Control, Enjoyment and Physical Activity in African American High School StudentsThe purpose of this study was to explain physical activity (PA) using Block and Block's (2006a) ego-resiliency and ego-control theory along with measures of self-control and PA enjoyment. One-hundred and seventy-seven African American high school students from a large Midwest inner city participated. In general, cluster analyses provided support for the importance of ego-resiliency and PA enjoyment as there were strongly affiliated with differential amounts of PA. Ego-control and self-control were also important in cluster formation but related to PA in somewhat unexpected ways.
Design methodology for barrier‐based two phase flow distributor
Authors: Al‐Rawashdeh Ma'moun , Nijhuis Xander , Rebrov Evgeny V. , Hessel Volker , Schouten Jaap C. 
Published: January 2012

AbstractThe barrier‐based distributor is a multiphase flow distributor for a multichannel microreactor which assures flow uniformity and prevents channeling between the two phases. For N number of reaction channels, the barrier‐based distributor consists of a gas manifold, a liquid manifold, N barrier channels for the gas, N barrier channels for the liquid, and N mixers for mixing the phases before the reaction channels. The flow distribution is studied numerically using a method based on the hydraulic resistive networks (RN). The single phase hydraulic RN model (Commenge et al., 2002;48:345–358) is extended for two phases gas‐liquid Taylor flow. For ReGL <30, the accuracy for the model was above 90%. The developed‐model was used to study the effects of fabrication tolerance and barrier channel dimensions. A design methodology has been proposed as an algorithm to determine the required hydraulic resistance in the barrier channels and their dimensions. This methodology is demonstrated using a numerical example. © 2012 American Institute of Chemical Engineers AIChE J, 2012
Moisture content distribution in semibatch drying processes, part II. Falling particle drying rate
Authors: Nitert Bernardus J. , Hounslow Michael J. 
Published: January 2012

AbstractThis article describes the evolution of the moisture content distribution in a population of wet particles during a semibatch drying process. The population balance model that is defined for this process includes falling particle drying rate, that is, the drying rate of a particle depends on its moisture content. This model is solved analytically using the “method of moments” and “method of characteristics.” Simulation experiments give realistic and meaningful results. Drying experiments still have to be performed to test the validity of the assumptions made in this model. © 2012 American Institute of Chemical Engineers AIChE J, 2012
Divergent body mass index trajectories between aboriginal and non‐aboriginal canadians 1994–2009—an exploration of age, period, and cohort effects
Authors: NG Carmina , Corey Paul N. , Young T. Kue 
Published: January 2012

AbstractObjectives:Aboriginal Canadians have a high burden of obesity and obesity‐related chronic conditions. Body mass index (BMI) trajectories from 1994 to 2009 were estimated for Aboriginal and non‐Aboriginal Canadians using self‐reported height and weight data from the National Population Health Survey to explore age, period, and cohort effects of BMI change.Methods:Linear growth curve models were estimated for 311 Aboriginal and 10,967 non‐Aboriginal respondents divided into five birth cohorts born in the 1940s, 50s, 60s, 70s, and 80s.Results:Overall, Aboriginal Canadians experienced higher rates of BMI increase over the 14‐year period. Rate of BMI increase was specifically higher for Aboriginal adults born in the 1960s and 1970s when compared with non‐Aboriginal adults. At ages 25, 35, and 45, recent‐born cohorts had consistently higher BMIs compared with earlier‐born cohorts with magnitudes of differences typically larger in the Aboriginal population. Recent‐born cohorts also exhibited steeper BMI trajectories.Conclusions:Cohort effects may be responsible for the divergent BMI trajectories between Aboriginal and non‐Aboriginal Canadians born in the 1960s and 1970s. Aboriginal Canadians, particularly of more recent‐born cohorts, experienced faster increases in BMI from 1994 to 2009 than non‐Aboriginal Canadians, suggesting that prevalence of obesity will continue to rise in this population without intervention. Am. J. Hum. Biol., 2012. © 2012 Wiley Periodicals, Inc.
Should I Stay or Should I Go? Time as a Variable in Open‐ended Psychoanalytic Psychotherapy
Authors: Nuetzel Eric J. , Larsen Randy 
Published: January 2012

ABSTRACTVarious factors could play a role in a patient's decision to leave treatment. This study asks whether patients who leave treatment before one year are different from those who stay beyond a year in open‐ended psychoanalytic psychotherapy, using a variety of experiential measures. Our data indicate that the personality trait of “openness” assessed at intake, correlates with staying in therapy, and that relationship factors as assessed by the patients during therapy correlate with staying in therapy at the beginning, at the average point of dropping out (before one year – average 31 weeks), and at the end of the study. These results indicate that the failure to engage in the therapeutic relationship is a salient factor in the phenomena of leaving before one year. Significant reductions in physical symptoms and other positive trends toward improvement do not emerge until such therapeutic engagement has occurred. We conclude that the personality trait of “openness,” and the quality of the therapeutic relationship significantly influence who will stay in open‐ended psychoanalytic psychotherapy and who will go. Those who stay in psychoanalytic psychotherapy beyond one year benefit more from the experience than those who leave. Copyright © 2012 John Wiley & Sons, Ltd.