bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complex heterozygous mutations in hereditary spherocytosis: A case report
Authors: He Miao , Lv Yan-Cheng , Wei Yu-Hong , Liu Lan-Qin , Guo Ling , Li Cheng 
Published: June 2024

BACKGROUND
The aim of this study was to investigate the complex heterozygous mutations of ANK1 and SPTA1 in the same individual and improve our understanding of hereditary spherocytosis (HS) in children. We also hope to promote the application of gene detection technology in children with HS, with the goals of identifying more related gene mutations, supporting the acquisition of improved molecular genetic information to further reveal the pathogenesis of HS in children, and providing important guidance for the diagnosis, treatment, and prevention of HS in children.
CASE SUMMARY
A 1-year and 5-month-old patient presented jaundice during the neonatal period, mild anemia 8 months later, splenic enlargement at 1 year and 5 months, and brittle red blood cell permeability. Genetic testing was performed on the patient, their parents, and sister. Swiss Model software was used to predict the protein structure of complex heterozygous mutations in ANK1 and SPTA1 . Genetic testing revealed that the patient harbored a new mutation in the ANK1 gene from the father and a mutation in the SPTA1 gene from the mother. Combined with the clinical symptoms of the children, it is suggested that the newly discovered complex heterozygous mutations of ANK1 and SPTA1 may be the cause, providing important guidance for revealing the pathogenesis, diagnosis, treatment, and promotion of gene detection technology in children with HS.
CONCLUSION
This case involves an unreported complex heterozygous mutation of ANK1 and SPTA1 , which provides a reference for exploring HS.
Optimization of acquisition patterns for establishing inter CubeSat optical communications
Authors: Rüddenklau René , Schitter Georg 
Published: June 2024

As commercially available CubeSats with up to six standardized units cannot achieve the precision required for an instantaneous establishment of a low-divergence optical inter-satellite link, search patterns are used to scan the remaining field of uncertainty. This analysis optimizes the simultaneously executed search pattern combinations of the two laser communication terminals involved. Based on a Monte Carlo simulation, the perturbations on these links are investigated, and the corresponding key performance parameters such as mean acquisition time and success rate are calculated. The results are penalized by the hardware specifications, including actuator and sensor bandwidths, given by their design. Residual attitude error components imply a significant influence on the acquisition process and are therefore presented within this work. The pattern pairs are fed through an automated optimization algorithm to tune and analyze them. In this particular scenario of two CubeISL models, the mean duration for a first detected acquisition hit is within a pattern period of 3.2 s for the best performing pairs spiral-rose and lissajous-rose. Assuming an uncertainty field of ±0.2deg due to limited attitude knowledge, success rates between 82.3% and 99.9% are achieved.
Versatile platform for electrically reconfigurable THz devices based on silicon Schottky-metasurfaces
Authors: Ahadi Saeedeh , Neshat Mohammad , Moravvej-Farshi Mohammad Kazem 
Published: June 2024

We propose a versatile platform to design tunable metasurface devices based on Au/n-Si Schottky diodes embedded in a split-ring resonator (SRR) devised on a Si-on-insulator (SOI) wafer. The horizontally formed diodes are connected in the SRR radial direction, reducing the overall junction capacitance of the metasurface array compared to its counterparts with vertically formed Schottky junctions. This reduction in the junction capacitance has an essential role in the switching speed of the metasurface between the On and Off states. By carefully varying the externally applied bias voltage to the Schottky diodes, one can manipulate the incident THz signal at the metasurface resonance frequencies by converting its resonance mode by switching states. We use the forenamed platform to design three fundamental THz devices: a modulator, a polarization switch, and a polarizing beam splitter. A reverse bias of V
R
=5V excites two LC resonances at 0.3 THz and 0.89 THz in the modulator, which fade away by switching the gate voltage to V
F
=0.49V, exciting a dipole resonance in the metasurface at 0.75 THz. The numerical results show that this THz modulator enjoys modulation depths of ≥92% at the LC resonances and a phase modulation of ∼1.16rad at 0.86 THz. An identical electric bias change of the Schottky diodes in the polarization switch alters the resonators from anisotropic to isotropic, changing the output wave polarization from circular with nearly 99% of the circular polarization percentage to linear or quasi-linear at four frequencies simultaneously. Additionally, the proposed THz polarization splitter can deflect the cross-polarized transmitted component from the normally outgoing co-polarized one with an angle of 70° at 0.56 THz. The splitting ratio is switched from 1:1 in reverse bias to 14:1 in forward bias by changing the bias to forward bias. We expect that the proposed designs in the THz frequency domain, benefiting from the several hundred GHz switching speed of the Schottky diodes array, will be beneficial in applications such as analysis of the complex organic structures or polarization modulation and polarization-dependent multiplexing/demultiplexing in wireless communication systems.
Factors associated with problematic internet use among University of Gondar undergraduate students, Northwest Ethiopia: Structural equation modeling
Authors: Tilahun Werkneh Melkie , Tadesse Asefa Adimasu , Wolde Haileab Fekadu , Gebreegziabher Zenebe Abebe , Abebaw Wondwosen Abey , Simegn Mulat Belay , Abay Lamrot Yohannes , Tesfie Tigabu Kidie 
Published: June 2024

BackgroundFor young adults and adolescents, excessive internet use has become a serious public health concern due to its negative impact on their health. It has been associated with detrimental effects on both physical and mental health. Negative academic outcomes were observed in the students, including missing classes, lower grades, and academic dismissal. Therefore, the purpose of the current study was to identify factors associated with PIU among undergraduate students at the University of Gondar.MethodA cross-sectional study was conducted at the University of Gondar among 1514 undergraduate students from June 1–20, 2022. The study participants were selected using a stratified simple random selection procedure. Using structural equation modeling, the degree of relationship was ascertained. A p-value of less than 0.05 and an adjusted regression coefficient with a 95% confidence interval (CI) were used to interpret the data.ResultsIn our study, being from non-health departments [β = 0.11, 95% CI: 0.037, 0.181], current alcohol use [β = 0.12, 95% CI: 0.061, 0.187], depressive symptoms [β = 0.23, 95% CI: 0.175, 0.291], insomnia symptoms [β = 0.12, 95% CI: 0.060, 0.196], and ADHD symptoms [β = 0.11, 95% CI: 0.049, 0.166] had a significant positive effect on PIU, while having a history of head injury had a significant negative effect [β = -0.12, 95% CI: -0.226, -0.021] on PIU.Conclusion and recommendationFactors such as current alcohol use, non-health department type, depressive symptoms, insomnia, and ADHD symptoms were positively associated with PIU. However, a history of head injuries was negatively associated with PIU. Therefore, strategies aimed at the early identification of PIU may lead to an improvement in the psychosocial health of university students.
Akceptacja, krytyka, odrzucenie. Reakcje na Veritatis splendor
Authors: Nowosad Sławomir 
Published: June 2024

Od dnia swojej publikacji encyklika Veritatis splendor Jana Pawła II doczekała się wyjątkowo licznych reakcji i omówień pochodzących z różnych stron chrześcijańskiego i teologicznego spektrum, nie tylko katolickiego. Niniejszy artykuł dokonuje analizy recenzji i komentarzy, które ukazały się przede wszystkim w języku angielskim, choć uwzględnia się także niektóre, ważniejsze teksty włoskie i hiszpańskie. Wielu recenzentów encykliki wyraża uznanie i akceptację dla papieskiego nauczania, opinie innych autorów są mieszane – pozytywne i negatywne, natomiast są i takie, które jednoznacznie krytykują papieską wizję moralności chrześcijańskiej, a nawet ją odrzucają. W swej treści recenzje te odnoszą się bądź do całościowej wizji encykliki, bądź do wybranych zagadnień szczegółowych, jak sposób korzystania z Pisma Świętego, prawo naturalne, konsekwencjalizm i proporcjonalizm oraz czyny intrinsece malum. Odrębna część artykułu poświęcona jest niektórym aspektom krytyki wizji życia moralnego w ujęciu Jana Pawła II, jaką od lat formułuje Charles Curran.
Screening for sickle cell disease: focus on newborn investigations
Authors: Mosca Andrea , Paleari Renata , Palazzi Giovanni , Pancaldi Alessia , Iughetti Lorenzo , Venturelli Donatella , Rolla Roberta , Pavanello Enza , Ceriotti Ferruccio , Ammirabile Massimiliano , Capri Stefano , Piga Antonio , Ivaldi Giovanni 
Published: June 2024

Abstract
Drepanocytosis is a genetic disease relevant for its epidemiological, clinical and socio-economic aspects. In our country the prevalence is highly uneven with peaks in former malaria areas, but migration flows in recent years have led to significant changes. In this document we review the screening programs currently existing in Italy with particular emphasis on newborn screening, which in other countries around the world, including within Europe, is at most universal and mandatory. The essential laboratory issues are reviewed, from sampling aspects (cord blood or peripheral), to the analytical (analytical methods dedicated to neonatal screening and adult carrier detection) and post analytical (reporting, informative) ones. An economic analysis based on data collected in the province of Modena is also proposed, clearly showing that neonatal screening is also beneficial from an economic point of view.
Governing Consumer Information in the Digital Age: Lessons from a Controversy Between a Food Rating App and Processed Meat Manufacturers
Authors: Lambert Élisabeth , Smolinski Jan 
Published: June 2024

Abstract
This article examines the legal response to a controversy on dietary information in the context of commercial court and appellate court rulings. Against a backdrop of health and environmental crises, the construction of information on such risks has become a sensitive issue for market actors, as a result of which courts are asked to arbitrate conflicts. This is particularly important at a time when informational mediations carried out by new actors increasingly take the form of digital ratings and augmented information. The dispute involving the firm Yuca and the French agro-industrial processed meat sector is a case in point. This paper analyses the structural arguments put forward in this legal dispute at the first instance and appeal stages. In the light of law and socio-economics, it untangles questions pertaining to the link between denigration and freedom of expression and the definition of the role of scientific research and consensus in the decisions. This leads us to shed light on the contents of the changing missions of two central types of actors: the mediators who monitor and regulate market practices and the judges that arbitrate these mediations and settle controversies.
Mechanical properties of web kapok/fiberglass-epoxy hybrid composites for marine structures
Authors: Mohd Idrus M. A. Mun’aim , Firdaus Faqihah Nazifa , Abdul Hamid Shamsul Effendy , Zoolfakar M. Redzuan , Shuib Raa Khimi , Tran Dai Lam , Saat Asmalina Mohamed 
Published: June 2024

Abstract
This study investigates the mechanical properties of hybrid composites composed of web kapok fibers and fiberglass reinforced with epoxy for potential application in the marine industry. The web kapok fibers were carefully processed using a carding technique to ensure better alignment and consistency. Various composite configurations were produced, and extensive mechanical testing was conducted, including flexural, tensile, and impact tests. The results revealed that the presence of two web kapok fiber layers within the composite significantly increased flexural strength and flexural modulus compared to pure fiberglass laminates. However, a single layer of web kapok fabrics exhibited the highest tensile strength, although it decreased with additional layers. The impact strength of these hybrid composites also showed promising results, especially when compared to raw fiberglass composites. Moreover, these composites exhibited improved resistance to water absorption and corrosion, making them potentially suitable for marine applications. This research highlights the potential of web kapok/fiberglass hybrid composites as an eco-friendly alternative for marine engineering, with implications for reduced environmental impact and sustainable technology in the industry.
Research progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases
Authors: Zhu Yifan , Wang Fangsheng , Xia Yu , Wang Lijuan , Lin Haihong , Zhong Tianyu , Wang Xiaoling 
Published: June 2024

Abstract
Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD), pose significant global health risks and represent a substantial public health concern in the contemporary era. A primary factor in the pathophysiology of these disorders is aberrant accumulation and aggregation of pathogenic proteins within the brain and spinal cord. Recent investigations have identified extracellular vesicles (EVs) in the central nervous system (CNS) as potential carriers for intercellular transport of misfolded proteins associated with neurodegenerative diseases. EVs are involved in pathological processes that contribute to various brain disorders including neurodegenerative disorders. Proteins linked to neurodegenerative disorders are secreted and distributed from cell to cell via EVs, serving as a mechanism for direct intercellular communication through the transfer of biomolecules. Astrocytes, as active participants in CNS intercellular communication, release astrocyte-derived extracellular vesicles (ADEVs) that are capable of interacting with diverse target cells. This review primarily focuses on the involvement of ADEVs in the development of neurological disorders and explores their potential dual roles – both advantageous and disadvantageous in the context of neurological disorders. Furthermore, this review examines the current studies investigating ADEVs as potential biomarkers for the diagnosis and treatment of neurodegenerative diseases. The prospects and challenges associated with the application of ADEVs in clinical settings were also comprehensively reviewed.
Experimental analysis of frost resistance and failure models in engineered cementitious composites with the integration of Yellow River sand
Authors: Raza Ali , Junjie Zhang , Shiwen Xu , Umar Muhammad , Chengfang Yuan 
Published: June 2024

Abstract
This study investigates the potential use of Yellow River sand (YRS) sourced from the lower reaches of the Yellow River in China as a sustainable and cost-effective substitute for quartz sand in engineered cementitious composites (ECCs). This region accumulates around 400 million tons of sand annually. The study evaluates the impact of different YRS replacement percentages (0, 25, 50, 75, and 100%) on mechanical and microstructure properties under freeze-thaw conditions, focusing on assessing the ECC durability during cooling cycles. The results show that YRS exhibits a smaller normal distribution of particle sizes compared to that of quartz sand and a 5.77 times greater specific surface area, affecting the ECC particle size distribution. After 300 cooling cycles, the R25 group maintains 97.5% of the initial mass and 79.4% of flexural strength, indicating superior durability. The R25 group also demonstrates a minimal decrease of 11.5% in equivalent bending strength, reaching a level of 104.4% compared to R0. The R25 group’s porosity is 30.80%, with an average pore size of 20.47 mm, showing 1.3% and 6.7% decreases compared to the R0 group. Additionally, this study establishes a failure progression equation using the Weibull probability distribution model, with calculated values closely aligning with measured values. Overall, this study recommends using YRS as a sustainable ECC material.
Adsorptive removal of cadmium from electroplating wastewater using hybrid composite of thiol-grafted seed gum of Tamarindus indica and Teff hay biocarbon
Authors: Rao Devendra Pratap , Krishnasamy Vimala Devi , Selvaraju Mayakannan , Sundramurthy Venkatesa Prabhu , Kandavalli Sumanth Ratna , Chitra Muthusamy Siva , Sivasamy Nanthakumar , Thirumoorthy Pradeep 
Published: June 2024

Abstract
This study examined the methods for preparing biocarbon from Teff hay (TBC) and thiol-grafted seed gum of Tamarindus indica (TH@TI-TBC) with the purpose of removing cadmium (Cd) from polluted electroplating waste water. To improve biocarbon adsorption, seed gum and thiol were added in a two-step combination. At a pH of 5.5, the most effective Cd adsorption was seen with TH@TI-TBC (261.47 mg g−1). While comparing to the Freundlich and Temkin models, the Langmuir and pseudo-second-order kinetic models found to be the best fit to the obtained adsorption data. After being treated with electroplating wastewater having 30 mg−1 L of cadmium, TH@TI-TBC was able to remove up to 89 % of the Cd, proving its effectiveness in dealing with adsorptive removal of Cd. Experimental studies and computational analyses revealed that electrostatic interaction and surface complexation were the principal underlying processes for Cd removal by TH@TI-TBC. In addition, an innovative material that can transform the waste into a product for environmental remediation must be developed using the vast amounts of Teff hay that are generated as agro-residue. So, this work proved that TH@TI-TBC can be made from Teff hay biocarbon could be a potential candidate for removing Cd from industrial wastewater.
Selenium levels and their association with thyroid autoimmunity and severe preeclampsia in pregnancy: Insights from a prospective ideal breast milk cohort study
Authors: Chung Chae Won , Kim Kyungsik , Park Sue K , Ju Dal Lae , Park Young Joo , Shin Choong Ho , Jun Jong Kwan , Chung June-Key , Song Yoon Ju , Lee Young Ah , Cheon Gi Jeong , Cho Sun Wook 
Published: June 2024

Objective
This study aimed to assess selenium status in South Korean pregnant women and its impact on maternal thyroid function and pregnancy outcomes.

Methods
‘Ideal Breast Milk (IBM) Cohort Study’ included 367 pregnant women out of 442 participants and categorized into three groups based on plasma selenium levels: deficient (< 70 μg/L), suboptimal (70–99 μg/L), and optimal (≥ 100 μg/L). During the second or third trimester, various blood parameters, including selenium, thyroid-stimulating hormone, free T4, free T3, and anti-thyroid peroxidase antibody levels, were measured. Thyroid parenchymal echogenicity was assessed as another surrogate marker for thyroid autoimmunity using ultrasonography.

Results
The median plasma selenium was 98.8 (range: 46.7–206.4) μg/L, and 30 individuals (8%) were categorized as deficient, while 164 (45%) were classified in the suboptimal group. Selenium deficiency was associated with markers of autoimmune thyroiditis, including positive anti-thyroid peroxidase antibody results (13.3 (deficient) vs 4.6 (optimal) %, P = 0.031) and thyroid parenchymal heterogeneity on ultrasound (33.3 (deficient) vs 14.6 (suboptimal) vs 17.3 (optimal) %, P = 0.042), independently of gestational age. The incidence of severe preeclampsia was higher in the group not taking selenium supplements, particularly among those with twin pregnancies, compared to the group taking selenium supplements (0 (selenium supplement) vs 9.0 (no supplement) %, P = 0.015).

Conclusion
Pregnant women experience mild selenium deficiency, which can lead to significant health issues including maternal thyroid autoimmunity and obstetrical complications during pregnancy. Guidelines for appropriate selenium intake according to the stage of pregnancy and the number of fetuses are needed.
THE MODELS OF INCLUSIVE EDUCATION: GOALS, IMPLEMENTATION, METHODOLOGY AND EVALUATION
Authors: KOKKALI Danai 
Published: June 2024

The aim of this article is to outline the models of inclusive education. Furthermore, the article highlights the goals, implementation, methodology and evaluation of inclusive education models. The relevance of the problem under consideration is that the inclusion phenomenon is an expression of every child’s right to educational equality, remains an important moral and political issue that needs to be addressed further. The feature of inclusive education is the willingness of teachers to accept students with special educational needs. Their attitudes and knowledge about inclusive education are important, as they are indicators of such willingness. The results of the study show that the role of teachers in inclusive education-co-education programs is very important and great as the teacher is the lever to mobilize such models of inclusive education. The implementation of co-education programs for children with or without special educational needs increases the quality of education because they achieve co-education, interaction of children with and without special educational needs, while promoting the interest of all students for mutual acceptance and improvement of interpersonal relationships.
IMPACT OF LITERARY WORKS ON DEVELOPING EMOTIONAL INTELLIGENCE AND RAISING HUMAN VALUES
Authors: ANDREIEVA Olena 
Published: June 2024

The article reveals theories of modeling and syntony and the way literary works play a cornerstone role in both forming and developing Emotional Intelligence (EI) in students. Formation and development of the universal and spiritual human values in students has always been one of the most important tasks of education. Nowadays the problem of degradation of people's morality, violence, consumer culture and the necessity of educating young people to develop their humanity and spirituality has been more actual than ever along with the importance of humanitarian education.
Cardiac risk in elderly individuals attended by basic health units
Authors: Martin Dantas Estélio Henrique , Andrade Dantas Karollyni Bastos , Siqueira Alves Anne Caroline , Porto Santana Maria Beatriz , Silva Sandes Maria Eduarda , Silva de Amorim Moisés , Baptista de Almeida Bastos Rafaela , Gomes Ribeiro da Costa Lúcio Flávio 
Published: June 2024

The objective was to assess the cardiac risk of elderly individuals attending Basic Health Units (UBS) in the North and South zones of Aracaju, SE. To achieve this objective, the study employed the Framingham Risk Score, which takes into account multiple cardiovascular risk factors, including age, blood pressure, heart rate, cholesterol levels, body composition, and other pertinent indicators. It's worth noting that some of these factors can be modified, while others cannot. A total of 76 elderly individuals participated in the study ( = 67 ± 6.07 years). The highest mean values for cardiovascular risk factors were found for total cholesterol ( = 199.10 ± 43.57 mg/dL) and low density lipoprotein ( = 129.57 ± 34.85 mg/dL), followed by the systolic blood pressure ( = 124.8 ± 19.88 bpm). The cardiovascular risk of the sample group was characterized as high ( = 0.29% ± 1.5%). Furthermore, the mentioned percentage delta reflects the change in value over a specific period, providing insights into relative changes in a dynamic context. The outcome of this study was a comprehensive assessment of the cardiac risk in these UBS attendees, contributing to the understanding and appropriate treatment of cardiovascular conditions in this population.