bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similar incidence of postoperative sciatic nerve palsy in direct anterior and posterior approach total hip arthroplasty
Authors: Coden Gloria S , Olsen Aaron A , Schoeller Lauren E , Niu Ruijia , Pichiotino Erin R , Freccero David M , Smith Eric L 
Published: April 2024

Background: Sciatic nerve palsy is a rare but devastating complication following total hip arthroplasty (THA). While the use of the direct anterior approach is increasing, limited data exist regarding sciatic nerve palsy and surgical approach. The purpose of this study was to determine the factors and outcomes associated with sciatic nerve palsy (SNP) after THA. Methods: A retrospective analysis was performed at a single institution of 7 SNP that occurred in 4045 THA via direct anterior approach and 10 SNP in 8854 THA via posterior approach, being operated between 01 January 2017 and 12 December 2021. SNP patients were matched 1:5 to patients without SNP. Medical records were reviewed for demographics including age, gender, body mass index (BMI), comorbidities, and preoperative indication. Additional workup of SNP patients including advanced imaging and reoperation were documented. Recovery grades were assigned to all SNP patients at most recent clinical follow-up. Results: 5 of the SNP were complete and 12 partial. They occurred as frequently with the direct anterior (0.17%) and posterior approach (0.11%, p  = 0.5). The presence of femur cables and reoperations were associated with SNP ( p  = 0.04 and p  = 0.002, respecitvely). Age, gender, BMI, comorbidities, and surgical indication had no effect on SNP. 4 of the 17 affected patients had almost complete recovery at latest follow-up. Conclusions: The incidence of SNP was similar in direct anterior and posterior approach. Surgeons should counsel patients regarding the risks of SNP regardless of the used approach.
Wrong, Strong, and Silent: What Happens when Automated Systems With High Autonomy and High Authority Misbehave?
Authors: Dekker Sidney W. A. , Woods David D. 
Published: April 2024

Warnings about the risks of literal-minded automation—a system that can’t tell if its model of the world is the world it is actually in—have been sounded for over 70 years. The risk is that a system will do the “right” thing—its actions are appropriate given its model of the world, but it is actually in a different world—producing unexpected/unintended behavior and potentially harmful effects. This risk—wrong, strong, and silent automation—looms larger today as our ability to deploy increasingly autonomous systems and delegate greater authority to such systems expands. It already produces incidents, outages of valued services, financial losses, and fatal accidents across different settings. This paper explores this general and out-of-control risk by examining a pair of fatal aviation accidents which revolved around wrong, strong and silent automation.
A deep learning-based calculation system for plaque stenosis severity on common carotid artery of ultrasound images
Authors: Liu Mengmeng , Gao Wenjing , Song Di , Dong Yinghui , Hong Shaofu , Cui Chen , Shi Siyuan , Wu Kai , Chen Jiayi , Xu Jinfeng , Dong Fajin 
Published: April 2024

Objectives Assessment of plaque stenosis severity allows better management of carotid source of stroke. Our objective is to create a deep learning (DL) model to segment carotid intima-media thickness and plaque and further automatically calculate plaque stenosis severity on common carotid artery (CCA) transverse section ultrasound images. Methods Three hundred and ninety images from 376 individuals were used to train (235/390, 60%), validate (39/390, 10%), and test (116/390, 30%) on a newly proposed CANet model. We also evaluated the model on an external test set of 115 individuals with 122 images acquired from another hospital. Comparative studies were conducted between our CANet model with four state-of-the-art DL models and two experienced sonographers to re-evaluate the present model’s performance. Results On the internal test set, our CANet model outperformed the four comparative models with Dice values of 95.22% versus 90.15%, 87.48%, 90.22%, and 91.56% on lumen-intima (LI) borders and 96.27% versus 91.40%, 88.94%, 91.19%, and 92.88% on media-adventitia (MA) borders. On the external test set, our model still produced excellent results with a Dice value of 92.41%. Good consistency of stenosis severity calculation was observed between CANet model and experienced sonographers, with Intraclass Correlation Coefficient (ICC) of 0.927 and 0.702, Pearson’s Correlation Coefficient of 0.928 and 0.704 on internal and external test set, respectively. Conclusions Our CANet model achieved excellent performance in the segmentation of carotid IMT and plaques as well as automated calculation of stenosis severity.
A pilot randomized control trial on the feasibility, acceptability, and initial effects of a digital-assisted parenting intervention for promoting mental health in Malaysian adolescents
Authors: Zulkefly Nor Sheereen , Dzeidee Schaff Anis Raihan , Zaini Nur Arfah , Mukhtar Firdaus , Dahlan Rahima 
Published: April 2024

Objective Online parenting interventions for enhancing child development, specifically mental health is relatively new in Malaysia. This pilot study tests the feasibility, acceptability, and initial effects of a universal digital-assisted parenting intervention (DaPI) in promoting mental health in adolescents by improving parental behaviors and self-efficacy. Methods A two-arm pilot randomized controlled trial was conducted. Twenty-four mothers of adolescent aged 10 to 14 years from a non-clinical sample were recruited online and randomly allocated into two groups (intervention [DaPI] and waitlist-control [WLC]). Eight weekly sessions were delivered online via technological devices. Feasibility outcomes were based on the participants’ engagement in DaPI and study retention. Primary (parental behaviors and self-efficacy) and secondary (adolescent mental health) outcomes were assessed using an online survey at baseline (T0), post-intervention (T1), and 1-month follow-up (T2). Data were analyzed using descriptive and inferential statistics and an intention-to-treat approach. Results The DaPI was well received by the mothers. Retention was high (81.8%) in both groups and intervention adherence was excellent (91.6%). Within-group analyses showed a significant decrease in physical control at T2 and an increase in parental self-efficacy at T1 and T2 among the DaPI mothers. No significant differences were observed in adolescents’ mental health at any time point. As for the WLC group, there were no significant differences in all the outcome variables across the three assessment moments. Between groups analyses revealed DaPI mothers had significant differences in proactive parenting at T1, and in positive reinforcement and lax control at T2. There were no significant differences in adolescents’ mental health between the groups at any time point. Discussion The DaPI is feasible and acceptable in the Malaysian context. Findings show promise regarding the initial effects of the DaPI. However, a larger RCT is needed to determine its effectiveness in promoting mental health of adolescents. Trial registration https://www.irct.ir/ ; identifier: IRCT20211129053207N1.
Analysis of Player Performance and Financial Costs Associated With Implementation of an Updated National Hockey League Concussion Protocol: A Retrospective Comparative Study
Authors: Gaudiani Michael A. , Castle Joshua P. , Wolterink Trevor D. , Sprys-Tellner Thomas J. , Haan Jager W. , Sean Lynch T. 
Published: April 2024

Background: An updated National Hockey League (NHL) concussion protocol (NHLCP) was established in the 2016-2017 season to mitigate the negative outcomes of sport-related concussions. However, few studies on the effects of implementing the NHLCP have been performed. Purpose: To define concussion incidence and investigate differences in NHL player performance after a concussion during periods before and after NHLCP implementation and assess the financial impact on NHL teams associated with NHLCP implementation. Study Design: Cohort study; Level of evidence, 3 Methods: This was a retrospective review of NHL players who sustained a concussion before (2000-2001 to 2015-2016 seasons) and after (2016-2017 to 2020-2021 seasons) implementing the NHLCP (pre-NHLCP and post-NHLCP groups). For each group, multiple performance metrics—including 30 days, 1 season, and 3 seasons before and after concussion—were compared for both groups. Return to play, total concussion cost, and association of return to play with cost were investigated using regression analysis. Results: A total of 452 players (423 skaters, 29 goalies) sustained concussions during the study period, including 331 players (315 skaters, 16 goalies) in the pre-NHLCP group and 121 players (108 skaters, 13 goalies) in the post-NHLCP group. For both groups, no significant differences in standard performance were observed during the 30-day and 1-season periods before and after concussion. The mean return to play was significantly higher in the pre-NHLCP group than in the post-NHLCP group (20.1 vs 15.7 days; P = .022). The mean adjusted player salary was not different between groups; nonetheless, the mean adjusted replacement player salary was significantly higher in the post-NHLCP group ($744,505 vs $896,942; P = .032). The mean cost of time missed did not differ between groups. The mean return to play time significantly decreased over the entire study period ( R2 = 0.33; P = .005), and the mean return to play time was positively associated with cost R2 = 0.215; P = .030). Conclusion: Concussion incidence did not change after implementation of the updated NHLCP; nonetheless, players had significantly less missed time from injury after protocol implementation. Changes in player performance 30 days and 1 year before and after concussion injury were not different before and after NHLCP implementation. No differences were found in the financial cost of concussions between the pre- and post-NHLCP groups, and missed time was significantly correlated with mean cost from missed time.
The dry-gel conversion synthesis of the lithium sodium borosilicate jadarite, LiNaSiB3O7(OH)
Authors: Rhodes Matilda , Armstrong Robin , Hillier Adrian D. , Putzolu Francesco , Kirk Caroline 
Published: April 2024

AbstractThe lithium sodium borosilicate jadarite, LiNaSiB3O7(OH), was first identified in 2007 in the Jadar basin, Serbia, where it forms the principal ore mineral of one of Europe's largest Li deposits. We report the successful application of the dry-gel conversion technique (DGC) to synthesise a jadarite analogue, via a dry-gel precursor made using sol-gel synthesis and the inclusion of the structure directing agent tetraethylammonium hydroxide (TEAOH). Pawley refinement of powder X-ray diffraction (PXRD) data collected on the synthetic sample was carried out using a monoclinic unit cell in space group P21/c (Whitfield et al., 2007), and gave refined unit cell parameters of a = 6.824(3) Å, b = 13.882(5) Å, c = 7.735(3) Å and β = 124.37(1)° (Rwp = 9.22). Inductively-coupled plasma optical emission spectroscopy (ICP–OES) on the synthetic sample confirmed an empirical formula of Li1.07Na1.40Si0.79B3O7.32(OH), based on three B atoms per formula unit (apfu). The synthetic product was found to be deficient in Si compared to natural jadarite from analysis of PXRD and ICP–OES data. Fourier-transform infrared spectroscopy (FTIR) showed that synthetic jadarite has peaks at 1415 and 1342 cm–1 and between 1180 and 900 cm–1, which are attributed to the presence of trigonal (BO3) and tetrahedral (BO4) borate groups characteristic of the natural jadarite structure, as well as a broad peak at 3441 cm–1 due to the presence of residual TEAOH. Scanning electron microscopy showed similarities in the morphologies between synthetic and natural jadarite particles.
Younger unrelated donors may be preferable over HLA match in the PTCy era: a study from the ALWP of the EBMT
Authors: Sanz Jaime , Labopin Myriam , Choi Goda , Kulagin Alexander , Peccatori Jacopo , Vydra Jan , Reményi Péter , Versluis Jurjen , Rovira Montserrat , Blaise Didier , Labussière-Wallet Hélène , Montoro Juan , Sica Simona , Meijer Ellen , Itälä-Remes Maija , Schaap Nicolaas , Bulabois Claude Eric , Piemontese Simona , Mohty Mohamad , Ciceri Fabio 
Published: April 2024

Abstract
There is a paucity of information on how to select the most appropriate unrelated donor (UD) in hematopoietic stem cell transplantation (HSCT) using posttransplant cyclophosphamide (PTCy). We retrospectively analyzed the characteristics of 10/10 matched UDs (MUDs) and 9/10 mismatched UDs (MMUDs) that may affect transplant outcomes in patients with acute myeloid leukemia (AML) in first or second complete remission (CR1 or CR2). The primary end point was leukemia-free survival (LFS). Overall, 1011 patients were included with a median age of 54 years (range, 18-77). Donors had a median age of 29 years (range, 18-64); 304 (30%) were females, of which 150 (15% of the whole group) were donors to male recipients, and 621 (61%) were MUDs; 522 (52%) had negative cytomegalovirus (CMV-neg) serostatus, of which 189 (19%) were used for CMV-neg recipients. Donor age older than 30 years had a negative impact on relapse (hazard ratio [HR], 1.38; 95% confidence interval [CI], 1.06-1.8), LFS (HR, 1.4; 95% CI, 1.12-1.74), overall survival (HR 1.45; 95% CI, 1.14-1.85) and graft-versus-host disease (GVHD) free, relapse-free survival (HR, 1.29; 95% CI, 1.07-1.56). In addition, CMV-neg donors for CMV-neg recipients were associated with improved LFS (HR, 0.74; 95% CI, 0.55-0.99). The use of MMUD and female donors for male recipients did not significantly impact any transplant outcomes. For patients undergoing HSCT from a UD with PTCy for AML, donor age &lt;30 years significantly improves survival. In this context, donor age might be prioritized over HLA match considerations. In addition, CMV-neg donors are preferable for CMV-neg recipients. However, further research is needed to validate and refine these recommendations.
Biologic agents licensed for severe asthma: a systematic review and meta-analysis of randomised controlled trials
Authors: Kyriakopoulos Christos , Gogali Athena , Markozannes Georgios , Kostikas Konstantinos 
Published: April 2024

Background:Six biologic agents are now approved for patients with severe asthma. This meta-analysis aimed to assess the efficacy and safety of licensed biologic agents in patients with severe asthma, including the recently approved tezepelumab.Methods:We searched MEDLINE, Embase and CENTRAL to identify randomised controlled trials involving licensed biologics until 31 January 2023. We used random-effects meta-analysis models for efficacy, including subgroup analyses by individual agents and markers of T2-high inflammation (blood eosinophils and fractional exhaled nitric oxide), and assessed safety.Results:48 studies with 16 350 patients were included in the meta-analysis. Biologics were associated with a 44% reduction in the annualised rate of asthma exacerbations (rate ratio 0.56, 95% CI 0.51–0.62) and 60% reduction of hospitalisations (rate ratio 0.40, 95% CI 0.27–0.60), a mean increase in the forced expiratory volume in 1 s of 0.11 L (95% CI 0.09–0.14), a reduction in asthma control questionnaire by 0.34 points (95% CI −0.46–−0.23) and an increase in asthma quality of life questionnaire by 0.38 points (95% CI 0.26–0.49). There was heterogeneity between different classes of biologics in certain outcomes, with overall greater efficacy in patients with T2 inflammation. Overall, biologics exhibited a favourable safety profile.Conclusions:This comprehensive meta-analysis demonstrated that licensed asthma biologics reduce exacerbations and hospitalisations, improve lung function, asthma control and quality of life, and limit the use of systemic corticosteroids, with a favourable safety profile. These effects are more prominent in patients with evidence of T2 inflammation.
Prognostic indicators of corneal ulcer clinical outcomes at a tertiary care center in the Bronx, New York
Authors: Kodali Sruthi , Khan Behram , Zong Amanda M. , Moon Jee-Young , Shrivastava Anurag , Daily Johanna P. , Gibralter Richard P. 
Published: April 2024

Abstract
Purpose
Corneal ulcers frequently result in ocular morbidity and may lead to permanent visual impairment if severe or untreated. This study aims to evaluate the association of patient factors and ocular exam findings on clinical outcomes for patients diagnosed with a corneal ulcer at a tertiary care center in the Bronx, New York.

Methods
A retrospective chart review was conducted on all ambulatory and admitted patients diagnosed with a corneal ulcer (identified using ICD-10 code H16.0) at Montefiore Medical Center, Bronx, NY between 2016–2022. Patient demographics, presence of known risk factors, characteristics of subsequent clinical course, and microbiological studies were noted. Clinical outcomes following treatment were longitudinally evaluated and categorized based upon the following criteria: 1) ‘No Surgical Intervention’: No severe complications or surgery required after presentation, 2) ‘Surgical Intervention’: Decline in BCVA with surgery required for a severe complication.

Results
The search criteria identified 205 patients (205 eyes) with the diagnosis of a corneal ulcer. Mean age was 55.3 ± 21.1 years (mean ± SD). Mean ulcer area at presentation was 7 ± 10.5 mm2. Mean LogMAR at presentation was 1.2 ± 1, and following treatment, improved to 1.0 ± 1. ‘Surgical Intervention’ outcome was associated with advanced age (p = 0.005), presence of ocular surface disease (p = 0.008), central location of ulcer (p = 0.014), greater ulcer area at presentation (p = 0.003), worse visual acuity at presentation (p < 0.001), and isolation of fungi (p = 0.004).

Conclusion
Identification of risk factors associated with a poor clinical prognosis can guide treatment and inform expectations for patients diagnosed with a corneal ulcer. Our study highlights the importance of timely diagnosis, work-up, and initiation of appropriate management, particularly in vulnerable populations where access to specialty care is logistically challenging.
Analysis and prediction of interactions between transmembrane and non-transmembrane proteins
Authors: Lu Chang , Jiang Jiuhong , Chen Qiufen , Liu Huanhuan , Ju Xingda , Wang Han 
Published: April 2024

Abstract
Background
Most of the important biological mechanisms and functions of transmembrane proteins (TMPs) are realized through their interactions with non-transmembrane proteins(nonTMPs). The interactions between TMPs and nonTMPs in cells play vital roles in intracellular signaling, energy metabolism, investigating membrane-crossing mechanisms, correlations between disease and drugs.

Results
Despite the importance of TMP-nonTMP interactions, the study of them remains in the wet experimental stage, lacking specific and comprehensive studies in the field of bioinformatics. To fill this gap, we performed a comprehensive statistical analysis of known TMP-nonTMP interactions and constructed a deep learning-based predictor to identify potential interactions. The statistical analysis describes known TMP-nonTMP interactions from various perspectives, such as distributions of species and protein families, enrichment of GO and KEGG pathways, as well as hub proteins and subnetwork modules in the PPI network. The predictor implemented by an end-to-end deep learning model can identify potential interactions from protein primary sequence information. The experimental results over the independent validation demonstrated considerable prediction performance with an MCC of 0.541.

Conclusions
To our knowledge, we were the first to focus on TMP-nonTMP interactions. We comprehensively analyzed them using bioinformatics methods and predicted them via deep learning-based solely on their sequence. This research completes a key link in the protein network, benefits the understanding of protein functions, and helps in pathogenesis studies of diseases and associated drug development.
Identification of different myofiber types in pigs muscles and construction of regulatory networks
Authors: Li Chenchen , Wang Yinuo , Sun Xiaohui , Yang Jinjin , Ren Yingchun , Jia Jinrui , Yang Gongshe , Liao Mingzhi , Jin Jianjun , Shi Xin’e 
Published: April 2024

Abstract
Background
Skeletal muscle is composed of muscle fibers with different physiological characteristics, which plays an important role in regulating skeletal muscle metabolism, movement and body homeostasis. The type of skeletal muscle fiber directly affects meat quality. However, the transcriptome and gene interactions between different types of muscle fibers are not well understood.

Results
In this paper, we selected 180-days-old Large White pigs and found that longissimus dorsi (LD) muscle was dominated by fast-fermenting myofibrils and soleus (SOL) muscle was dominated by slow-oxidizing myofibrils by frozen sections and related mRNA and protein assays. Here, we selected LD muscle and SOL muscle for transcriptomic sequencing, and identified 312 differentially expressed mRNA (DEmRs), 30 differentially expressed miRNA (DEmiRs), 183 differentially expressed lncRNA (DElRs), and 3417 differentially expressed circRNA (DEcRs). The ceRNA network included ssc-miR-378, ssc-miR-378b-3p, ssc-miR-24-3p, XR_308817, XR_308823, SMIM8, MAVS and FOS as multiple core nodes that play important roles in muscle development. Moreover, we found that different members of the miR-10 family expressed differently in oxidized and glycolytic muscle fibers, among which miR-10a-5p was highly expressed in glycolytic muscle fibers (LD) and could target MYBPH gene mRNA. Therefore, we speculate that miR-10a-5p may be involved in the transformation of muscle fiber types by targeting the MYHBP gene. In addition, PPI analysis of differentially expressed mRNA genes showed that ACTC1, ACTG2 and ACTN2 gene had the highest node degree, suggesting that this gene may play a key role in the regulatory network of muscle fiber type determination.

Conclusions
We can conclude that these genes play a key role in regulating muscle fiber type transformation. Our study provides transcriptomic profiles and ceRNA interaction networks for different muscle fiber types in pigs, providing reference for the transformation of pig muscle fiber types and the improvement of meat quality.