bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of penicillin G on the biliary excretion of cholephilic compounds in rats
Authors: Fukami Masako , Tanka Atsushi , Takikawa Hajime 
Published: March 2011

AbstractAimPenicillin G is reported to increase bile flow by increasing biliary glutathione excretion, as well as the biliary excretion of penicillin G itself. In order to study the effect of penicillin G on the hepatic excretory pathway, the effect of colchicine and genipin on the increase of biliary glutathione excretion induced by penicillin G was studied in rats. The effect of penicillin G on the biliary excretion of sulfobromophthalein and erythromycin was also studied, together with the effect of penicillin G on cholestasis induced by estradiol‐17β‐glucuronide.MethodsAfter bile duct cannulation, penicillin G was administered to rats at the rate of 0.5 μmol/min/100 g. The effect was examined of colchicine pretreatment (0.2 mg/100 g) and genipin administration (0.5 μmol/min/100 g) on biliary glutathione excretion increased by penicillin G infused at the rate of 0.5 μmol/min/100 g. The effect of penicillin G on the biliary excretion of sulfobromophthalein and erythromycin (0.2 and 0.1 μmol/min/100 g for 90 min, respectively) was studied, together with the effect of penicillin G on cholestasis induced by estradiol‐17β‐glucuronide (0.075 μmol/min/100 g for 20 min).ResultsPenicillin G increased bile flow and biliary glutathione excretion, which were not inhibited by colchicine or genipin. Biliary penicillin G excretion was markedly reduced in Eisai hyperbilirubinemic rats (EHBR) and Mrp2‐deficient rats. Biliary sulfobromophthalein and erythromycin excretion was unchanged by penicillin G. Cholestasis induced by estradiol‐17β‐glucuronide was not relieved by penicillin G.ConclusionsIt was shown that colchicine‐sensitive vesicular transport has no role on the penicillin G‐induced insertion of Mrp2 into the canalicular membrane, as has been observed with genipin. Although the choleresis of penicillin G is thought to be due to the increased biliary excretion of glutathione and penicillin G itself by Mrp2, the mechanism of Mrp2 insertion by penicillin G is thought to be partly different from that by genipin.
From political economy to sociology: Francis Galton and the social-scientific origins of eugenics
Authors: RENWICK CHRIS 
Published: March 2011

AbstractHaving coined the word ‘eugenics’ and inspired leading biologists and statisticians of the early twentieth century, Francis Galton is often studied for his contributions to modern statistical biology. However, whilst documenting this part of his work, historians have frequently neglected crucial aspects of what motivated Galton to establish his eugenics research programme. Arguing that his work was shaped more by social than by biological science, this paper addresses these oversights by tracing the development of Galton's programme, from its roots in a debate about political economy to his appeals for it to be taken up by sociologists. In so doing, the paper not only returns Galton's ideas to their original context but also provides a reason to reflect on the place of the social sciences in history-of-science scholarship.
Methods of plant breeding in the genome era
Authors: XU SHIZHONG , HU ZHIQIU 
Published: March 2011

SummaryMethods of genomic value prediction are reviewed. The majority of the methods are related to mixed model methodology, either explicitly or implicitly, by treating systematic environmental effects as fixed and quantitative trait locus (QTL) effects as random. Six different methods are reviewed, including least squares (LS), ridge regression, Bayesian shrinkage, least absolute shrinkage and selection operator (Lasso), empirical Bayes and partial least squares (PLS). The LS and PLS methods are non-Bayesian because they do not require probability distributions for the data. The PLS method is introduced as a special dimension reduction scheme to handle high-density marker information. Theory and methods of cross-validation are described. The leave-one-out cross-validation approach is recommended for model validation. A working example is used to demonstrate the utility of genome selection (GS) in barley. The data set contained 150 double haploid lines and 495 DNA markers covering the entire barley genome, with an average marker interval of 2·23 cM. Eight quantitative traits were included in the analysis. GS using the empirical Bayesian method showed high predictability of the markers for all eight traits with a mean accuracy of prediction of 0·70. With traditional marker-assisted selection (MAS), the average accuracy of prediction was 0·59, giving an average gain of GS over MAS of 0·11. This study provided strong evidence that GS using marker information alone can be an efficient tool for plant breeding.
Statistical analysis of genetic interactions
Authors: YI NENGJUN 
Published: March 2011

SummaryMany common human diseases and complex traits are highly heritable and influenced by multiple genetic and environmental factors. Although genome-wide association studies (GWAS) have successfully identified many disease-associated variants, these genetic variants explain only a small proportion of the heritability of most complex diseases. Genetic interactions (gene–gene and gene–environment) substantially contribute to complex traits and diseases and could be one of the main sources of the missing heritability. This paper provides an overview of the available statistical methods and related computer software for identifying genetic interactions in animal and plant experimental crosses and human genetic association studies. The main discussion falls under the three broad issues in statistical analysis of genetic interactions: the definition, detection and interpretation of genetic interactions. Recently developed methods based on modern techniques for high-dimensional data are reviewed, including penalized likelihood approaches and hierarchical models; the relationships between these methods are also discussed. I conclude this review by highlighting some areas of future research.
Genomic selection in livestock populations
Authors: GODDARD MICHAEL E. , HAYES BEN J. , MEUWISSEN THEO H. E. 
Published: March 2011

SummaryMost traits of economic importance in livestock are either quantitative or complex. Despite considerable efforts, there has been only limited success in identifying the polymorphisms that cause variation in these traits. Nevertheless, selection based on estimated breeding values (BVs), calculated from data on phenotypic performance and pedigree has been very successful. Genomic tools, such as single nucleotide polymorphism (SNP) chips, have led to a new method of selection called ‘genomic selection’ in which dense SNP genotypes covering the genome are used to predict the BV. In this review we consider the statistical methodology for estimating BVs from SNP data, factors affecting the accuracy, the long-term response to genomic selection and the design of breeding programmes including the management of inbreeding.
Characterizing allelic association in the genome era
Authors: WEIR B. S. , LAURIE C. C. 
Published: March 2011

SummaryWhole genome data are allowing the estimation of population genetic parameters with an accuracy not imagined 50 years ago. Variation in these parameters along the genome is being found empirically where once only approximate theoretical values were available. Along with increased information, however, has come the issue of multiple testing and the realization that high values of the coefficients of variation of quantities such as relatedness measures may make it difficult to draw inferences. This review concentrates on measures of allelic association within and between individuals and within and between populations.
No reliable gender differences in attachment across the lifespan
Authors: Bakermans-Kranenburg Marian J. , van IJzendoorn Marinus H. 
Published: March 2011

AbstractIn middle childhood, boys show more avoidant attachments and girls more ambivalent attachments as a prelude to gender differentiation in reproductive strategies. However, we have failed to find systematic and method-independent gender differences in middle or late childhood attachments, nor in adult attachment representations. We conclude that Del Giudice's model rests on a brittle empirical basis.
Texto de síntesis IV: Identificación—Principio fundamental
Authors: de Preux J. 
Published: March 2011

Las familias tienen derecho a conocer la suerte de sus miembros (P. I, art. 32).Cada Parte en conflicto debe buscar a las personas cuya desaparición haya señalado una Parte adversa y comunicar todas las informaciones pertinentes sobre las personas de que se trate (P.I, art. 33).
Los Protocolos de 1977 y la Cruz Roja Neerlandesa
Authors: Kalshoven Frits 
Published: March 2011

Los Países Bajos contribuyeron en gran medida a la redacción del texto de los Protocolos de 1977 y fue uno de los primeros Estados en firmar esos instrumentos, el 12 de diciembre de 1977, en Berna. Sin embargo, hasta hoy, aún no los ha ratificado. Por qué ese retraso?Hay numerosas razones para ello. Por una parte, los Países Bajos son miembros de la Organizatión del Tratado del Atlántico Norte (OTAN), la cual necesitó mucho tiempo para evaluar los Protocolos a la luz de sus planes de defensa militar. Por otra, según las normas y la práctica constitucionales, siempre que el Gobierno holandés desea ratificar un tratado, debe obtener primero la autorización de ambas Cámaras del Parlamento.
The integration of local chromatic motion signals is sensitive to contrast polarity
Authors: WUERGER SOPHIE M. , RUPPERTSBERG ALEXA , MALEK STEPHANIE , BERTAMINI MARCO , MARTINOVIC JASNA 
Published: March 2011

AbstractGlobal motion integration mechanisms can utilize signals defined by purely chromatic information. Is global motion integration sensitive to the polarity of such color signals? To answer this question, we employed isoluminant random dot kinematograms (RDKs) that contain a single chromatic contrast polarity or two different polarities. Single-polarity RDKs consisted of local motion signals with either a positive or a negative S or L–M component, while in the different-polarity RDKs, half the dots had a positive S or L–M component, and the other half had a negative S or L–M component. In all RDKs, the polarity and the motion direction of the local signals were uncorrelated. Observers discriminated between 50% coherent motion and random motion, and contrast thresholds were obtained for 81% correct responses. Contrast thresholds were obtained for three different dot densities (50, 100, and 200 dots). We report two main findings: (1) dependence on dot density is similar for both contrast polarities (+S vs. −S, +LM vs. −LM) but slightly steeper for S in comparison to LM and (2) thresholds for different-polarity RDKs are significantly higher than for single-polarity RDKs, which is inconsistent with a polarity-blind integration mechanism. We conclude that early motion integration mechanisms are sensitive to the polarity of the local motion signals and do not automatically integrate information across different polarities.
From spatial frequency contrast to edge preponderance: the differential modulation of early visual evoked potentials by natural scene stimuli
Authors: HANSEN BRUCE C. , JACQUES THEODORE , JOHNSON AARON P. , ELLEMBERG DAVE 
Published: March 2011

AbstractThe contrast response function of early visual evoked potentials elicited by sinusoidal gratings is known to exhibit characteristic potentials closely associated with the processes of parvocellular and magnocellular pathways. Specifically, the N1 component has been linked with parvocellular processes, while the P1 component has been linked with magnocellular processes. However, little is known regarding the response properties of the N1 and P1 components during the processing and encoding of complex (i.e., broadband) stimuli such as natural scenes. Here, we examine how established physical characteristics of natural scene imagery modulate the N1 and P1 components in humans by providing a systematic investigation of component modulation as visual stimuli are gradually built up from simple sinusoidal gratings to highly complex natural scene imagery. The results suggest that the relative dominance in signal output of the N1 and P1 components is dependent on spatial frequency (SF) luminance contrast for simple stimuli up to natural scene imagery possessing few edges. However, such a dependency shifts to a dominant N1 signal for natural scenes possessing abundant edge content and operates independently of SF luminance contrast.
The new Amplatzer duct occluder II: when is its use advantageous?
Authors: Venczelova Zuzana , Tittel Peter , Masura Jozef 
Published: March 2011

AbstractObjectivesTo determine the safety and efficacy of the Amplatzer duct occluder and the Amplatzer duct occluder II in different types of arterial ducts, and to determine in which types of ducts the use of this new device can be advantageous.MethodsAll children with a device-based ductal closure between September, 2005 and February, 2010 were included. We retrospectively analysed the catheterisation and follow-up data.ResultsBetween September, 2005 and February, 2010, 44 ducts were closed with the Amplatzer duct occluder – group Amplatzer duct occluder – and 52 ducts were closed with the Amplatzer duct occluder II – group Amplatzer duct occluder II. In the Amplatzer duct occluder group, the mean age was 3 years and 4 months, and the mean weight was 14.7 kilograms. Closure was successfully performed in all children. Complete closure at 24 hours was attained in 42 of 44 children (95.45%). No major complications occurred. In the Amplatzer duct occluder II group, the mean age was 6 years and 2 months, and the mean weight was 25.4 kilograms. Closure was successfully performed in all children, except in two children in whom the occluder protruded into the aortic isthmus and was replaced by the Amplatzer duct occluder. Complete closure at 24 hours was attained in 51 of 52 children (98.08%). No major complications occurred.ConclusionIn our experience, duct closure with the Amplatzer duct occluder II is a safe and effective method. The advantages of using it are the smaller sheath sizes and softer shape.
Donated breast milk substitutes and incidence of diarrhoea among infants and young children after the May 2006 earthquake in Yogyakarta and Central Java
Authors: Hipgrave David B , Assefa Fitsum , Winoto Anna , Sukotjo Sri 
Published: March 2011

AbstractObjectiveDistribution of breast milk substitutes (BMS) after the 2006 Yogyakarta earthquake was uncontrolled and widespread. We assessed the magnitude of BMS distribution after the earthquake, its impact on feeding practices and the association between consumption of infant formula and diarrhoea among infants and young children.DesignOne month after the earthquake, caregivers of 831 children aged 0–23 months were surveyed regarding receipt of unsolicited donations of BMS, and on recent child-feeding practices and diarrhoeal illness.SettingCommunity-level survey in an earthquake-affected district.SubjectsPrimary caregivers of surveyed children.ResultsIn all, 75 % of households with an infant aged 0–5 months and 80 % of all households surveyed received donated infant formula; 76 % of all households received commercial porridge and 49 % received powdered milk. Only 32 % of 0–5-month-old infants had consumed formula before the earthquake, but 43 % had in the 24 h preceding the survey (P< 0·001). Consumption of all types of BMS was significantly higher among those who received donated commodities, regardless of age (P< 0·01). One-week diarrhoea incidence among those who received donated infant formula (25·4 %) was higher than among those who did not (11·5 %; relative risk = 2·12, 95 % CI = 1·34, 3·35). The rate of diarrhoea among those aged 12–23 months was around five times the pre-earthquake rate.ConclusionsThere were strong associations between receipt of BMS and changes in feeding practices, and between receipt of infant formula and diarrhoea. Uncontrolled distribution of infant formula exacerbates the risk of diarrhoea among infants and young children in emergencies.
Where has all the chocolate gone? A national survey assesses the effects of recent legislation to improve the nutritional quality of English secondary-school vending
Authors: Matthews Anne , Nelson Michael , Kaur Asha , Rayner Mike , Kelly Paul , Cowburn Gill 
Published: March 2011

AbstractObjectiveObesity levels are rising in almost all parts of the world, including the UK. School food offers children in Great Britain between 25 % and 33 % of their total daily energy, with vending typically offering products high in fat, salt or sugar. Government legislation of 2007 to improve the quality of school food now restricts what English schools can vend. In assessing the effect of this legislation on the quality of English secondary-school vending provision, the response of schools to these effects is explored through qualitative data.DesignA longitudinal postal and visit-based inventory survey of schools collected vending data during the academic year 2006–2007 (pre-legislation), 2007–2008 and 2008–2009 (both post-legislation). Interviews with school staff explored issues of compliance. Product categorisation and analysis were carried out by product type, nutrient profiling and by categories of foods allowed or prohibited by the legislation.SettingEnglish secondary schools.SubjectsA representative sample of 279 schools including sixty-two researcher-visited inventory schools participated in the research.ResultsSchool vending seems to have moved towards compliance with the new standards – now drinks vending predominates and is largely compliant, whereas food vending is significantly reduced and is mostly non-compliant. Sixth form vending takes a disproportionate share of non-compliance. Vending has declined overall, as some schools now perceive food vending as uneconomic. Schools adopting a ‘whole-school’ approach appeared the most successful in implementing the new standards.ConclusionsGovernment legislation has achieved significant change towards improving the quality of English school vending, with the unintended consequence of reducing provision.
Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling
Authors: Welham Melanie J. , Kingham Emmajayne , Sanchez-Ripoll Yolanda , Kumpfmueller Benjamin , Storm Michael , Bone Heather 
Published: March 2011

ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up the adult organism. This property of pluripotency makes ESCs attractive as a model system for studying early development and for the generation of specific cell types for use in regenerative medicine and drug screening. In order to harness their potential, the molecular mechanisms regulating ESC pluripotency, proliferation and differentiation (i.e. cell fate) need to be understood so that pluripotency can be maintained during expansion, while differentiation to specific lineages can be induced accurately when required. The present review focuses on the potential roles that PI3K (phosphoinositide 3-kinase) and GSK-3 (glycogen synthase kinase 3)-dependent signalling play in the co-ordination and integration of mouse ESC pluripotency and proliferation and contrast this with our understanding of their functions in human ESCs.
K 1-6: An Asymmetric Planetary Nebula with a Binary Central Star
Authors: Frew David J. , Stanger Jeff , Fitzgerald Michael , Parker Quentin , Danaia Lena , McKinnon David , Guerrero Martín A. , Hedberg John , Hollow Robert , An Yvonne , Bor Shu Han , Colman Isabel , Graham-White Claire , Li Qing Wen , Mai Juliette , Papadakis Katerina , Picone-Murray Julia , Vo Hoang Melanie , Yean Vivian 
Published: March 2011

AbstractWe present new imaging data and archival multiwavelength observations of the little-studied emission nebula K 1-6 and its central star. Narrow-band images inHα (+[N II]) and [O III] taken with the Faulkes Telescope North reveal a stratified, asymmetric, elliptical nebula surrounding a central star which has the colours of a late G or early K-type subgiant or giant. GALEX ultraviolet images reveal a very hot subdwarf or white dwarf coincident in position with this star. The cooler, optically dominant star is strongly variable with a period of 21.312± 0.008 days, and is possibly a high-amplitude member of the RS CVn class, although an FK Com classification is also possible. Archival ROSAT data provide good evidence that the cool star has an active corona. We conclude that K 1-6 is most likely an old bona fide planetary nebula at a distance of ∼1.0 kpc, interacting with the interstellar medium, and containing a binary or ternary central star. The observations and data analyses reported in this paper were conducted in conjunction with Year 11 high school students as part of an Australian Research Council Linkage Grant science education project, denoted Space To Grow, conducted jointly by professional astronomers, educational researchers, teachers, and high-school students.
DSPSR: Digital Signal Processing Software for Pulsar Astronomy
Authors: van Straten W. , Bailes M. 
Published: March 2011

Abstractdspsr is a high-performance, open-source, object-oriented, digital signal processing software library and application suite for use in radio pulsar astronomy. Written primarily in C++, the library implements an extensive range of modular algorithms that can optionally exploit both multiple-core processors and general-purpose graphics processing units. After over a decade of research and development, dspsr is now stable and in widespread use in the community. This paper presents a detailed description of its functionality, justification of major design decisions, analysis of phase-coherent dispersion removal algorithms, and demonstration of performance on some contemporary microprocessor architectures.
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
Authors: Sadowsky Jack D. , Burlingame Mark A. , Wolan Dennis W. , McClendon Christopher L. , Jacobson Matthew P. , Wells James A. 
Published: March 2011

There is significant interest in identifying and characterizing allosteric sites in enzymes such as protein kinases both for understanding allosteric mechanisms as well as for drug discovery. Here, we apply a site-directed technology, disulfide trapping, to interrogate structurally and functionally how an allosteric site on the Ser/Thr kinase, 3-phosphoinositide-dependent kinase 1 (PDK1)—the PDK1-interacting-fragment (PIF) pocket—is engaged by an activating peptide motif on downstream substrate kinases (PIFtides) and by small molecule fragments. By monitoring pairwise disulfide conjugation between PIFtide and PDK1 cysteine mutants, we defined the PIFtide binding orientation in the PIF pocket of PDK1 and assessed subtle relationships between PIFtide positioning and kinase activation. We also discovered a variety of small molecule fragment disulfides (< 300 Da) that could either activate
or
inhibit PDK1 by conjugation to the PIF pocket, thus displaying greater functional diversity than is displayed by PIFtides conjugated to the same sites. Biochemical data and three crystal structures provided insight into the mechanism of action of the best fragment activators and inhibitors. These studies show that disulfide trapping is useful for characterizing allosteric sites on kinases and that a single allosteric site on a protein kinase can be exploited for both activation and inhibition by small molecules.