bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of five-year outcomes of anterior cruciate ligament tears repaired with different techniques
Authors: Pupynin D. Yu. , Lychagin A. V. , Gritsyuk A. A. 
Published: June 2024

Introduction Primary repair of the anterior cruciate ligament (ACL) torn from the femur and the synovial membrane being intact can be an indication for two competing methods including dynamic intraligamentary stabilization (DIS) as the saving method and resection of the stump and primary autoplasty as a more traumatic option.The purpose was to evaluate the five-year results of DIS in comparison with early ACL reconstruction of the knee joint.Material and methods A review and statistical analysis of outcomes of 72 patients with ACL injuries (47 males and 25 females) were performed. The patients aged between 18 and 45 years (30.9 ± 8.5), with the length of time from injury ranging from 3 to 21 days (10.6 ± 5.0) and the Tegner activity score of 5 (1–9; 5.8 ± 0.9) prior to injury. DIS was performed for the first group of patients (n = 39) who arthroscopically were diagnosed with ACL torn off the femur with the synovial membrane preserved. Early ACL repair was performed for the controls (second group, n = 33).Results VAS scored 1.4 ± 0.8 in group I and 1.9 ± 0.8 in group II at 6 months, p = 0.004. Patient satisfaction scored 8.0 ± 0.8 in group I and 7.4 ± 0.8 in group II at 12 months, p = 0.003. Tegner activity level scored 6.5 ± 0.9 in group I and 6.3 ± 0.8 in group II at 12 months, p = 0.014. The Lysholm knee score measured 91.1 ± 2.2 in group I and 88.6 ± 3.5 in group II at 12 months, p = 0.001. Five-year dynamic observation showed relapses of anterior-medial instability of the knee joint in 10 patients (13.9 %), with 4 patients in group I (10.3 %) and 6 patients in group II (18.2 %).Discussion Outcomes of proximal ACL tears with intact synovium can be as good as with ACL repair. Removal of the torn cruciate ligament with the synovium being intact and grafting may be an unnecessary and aggressive approach.Conclusion Dynamic intraligamentous stabilization as compared to early ACL repair shows a faster recovery of physical activity at a short term and less relapses of knee joint instability at a long term.
MSCT-semiotics of vertebrae in patients with cervical spine stenosis
Authors: Sufianov A. A. , Nabiev D. N. , Burtsev A. V. , Sufianov R. A. , Karsanova M. T. , Piterov V. V. 
Published: June 2024

Introduction The number of surgical interventions on the cervical spine for stenosis has been constantly increasing. This fact proves that there is a need for careful preoperative preparation that would consider the complexity of the intervention and the age of the patients.Purpose To substantiate the need to include the MSCT data processing algorithm of bone tissue density of vertebral bodies and arches to assess their quality for planning osteoplastic decompressive laminoplasty in patients with cervical spine stenosis due to degenerative changes.Material and methods This single-center retrospective study investigated qualitative and quantitative characteristics of the spine with radiography and multislice computed tomography (MSCT) in 82 patients with degenerative diseases of the cervical spine and associated spinal canal stenosis (CSS).Results and discussion The data obtained indicate a tendency for the total density of the cervical vertebrae to increase from C3 to C5 and to decrease caudally, with minimal density in C7 without signs of osteoporosis. A similar trend is characteristic of trabecular bone. The density of the osteon layer of the vertebral arch cortex differs significantly from the density of the outer and inner plates. The total density of the compact layer of the vertebral arch cortex exceeds 785.15 ± 38.4 HU.Conclusion The data obtained justify the need to include the study of the density of vertebral bodies, vertebral arches, and its thickness in the MSCT data processing algorithm to develop a plan for surgical intervention in patients with cervical spine stenosis in order to obtain objective data on the quality of the bone.
Experience in early minimally invasive fixation of pubic symphysis disruption with a system of transpedicular screws in patients with combined pelvic trauma (pilot study)
Authors: Petrov A. V. , Kazhanov I. V. , Badalov V. I. , Mikityuk S. I. , Presnov R. A. , Manukovsky V. A. , Gavrishuk Ya. V. , Kolchanov E. A. 
Published: June 2024

Introduction Challenges of treating the injuries of pubic symphysis in patients with combined pelvic injury require developing new techniques for stable minimally invasive osteosynthesis in the acute period of trauma.Purpose of the work was to assess the application of low invasive fixation of the pubic symphysis with a system of transpedicular screws in the patients with combined unstable pelvic injuries in the acute period of the traumatic disease.Materials and methods The results of treatment of 12 patients with polytrauma with unstable pelvic injury with rupture of the pubic symphysis who were treated at Dzhanelidze Research Institute of Emergency Medicine, St. Petersburg, in the period from 2017 to 2023, were analyzed. All the patients underwent final minimally invasive fixation of the pubic symphysis with a system of transpedicular screws in the early period of the traumatic disease.Results The overall assessment of the results in 12 patients found no complications or technical errors during the installation of transpedicular screws. Control CT scans of the pelvis showed that osteosynthesis was stable in all patients, and the position of metal was correct in all. One patient from the study group died in the clinic from massive pulmonary embolism. The long-term results in 11 patients in the period from 6 months to 3 years after trauma were evaluated as excellent and good anatomical and functional results in 10 patients, one case had fair outcome.Discussion The use of bone plates to fix ruptures of the symphysis pubis leads to disruption of its physiological mobility, and the patient’s activity in the postoperative period can cause an implant fracture. Original dynamic plates and wire cerclage help avoid this complication; however, all these techniques involve significant surgical trauma and blood loss, as well as the risk of postoperative wound suppuration. Minimally invasive methods of fixation using cannulated screws, systems such as Endobutton, Tight Rope can reduce intraoperative trauma and the risk of complications (blood loss, suppuration); however, the procedure for their installation is quite complex and lengthy, and for greater stability, external fixation of the pelvic ring is often required. The proposed minimally invasive fixation of the pubic symphysis with a system of transpedicular screws avoids a lot of shortcomings and is sufficiently stable.Conclusion The method of minimally invasive fixation of the pubic symphysis with a system of transpedicular screws meets current requirements in the treatment of patients with polytrauma and unstable pelvic injury, and it may be successfully used in the acute period of trauma.
A 3D German-designed brace used to treat adolescent idiopathic scoliosis
Authors: Blandinskij V. F. , Mogilyantseva T. O. , Pavlova Ya. I. 
Published: June 2024

Introduction Adolescent Idiopathic Scoliosis (AIS) is a condition that affects an otherwise healthy child 10 years of age or older and is the high risk of severe deformity and surgery. Different brace applications include the Milwaukee Brace, Boston Scoliosis Brace, TLSO and others, and the success rates of orthoses vary. With little experience in the use of the Chêneau-type corset, the brace provides an effective means for the active correction of scoliotic spinal deformity.The objective was to demonstrate an outcome with a 3D functional corrective German-designed corset used to treat a patient with AIS in the period from the onset of the curve to the onset of skeletal maturity.Material and methods The medical history of patient S. including anamnestic, clinical and radiological findings recorded 2018 and 2023 when she used a 3D German-designed (3D GD) corset. The corset design was defined as 3CL/B2 according to the Lehnert – Schroth scoliotic classification as modified by Rigo.Results The left-sided thoracolumbar curve of a 9-year-old patient with a Risser sign of 0 and a Cobb angle of 25° at baseline decreased to 12° at the age of 16 years (Risser sign — 5) due to bracing.Discussion The AIS was diagnosed in the patient at the age of 5 years and bracing was initiated at the age of 9. The curve correction using 3D GD brace was based on the principles offered by Chêneau. The patient used the corset for 20 hours per day. The initial brace correction was 90 %. The curve decreased from Cobb angle 25° to 12° over a six-year period of brace treatment with no need for surgery. Three cases with identical outcomes were reported with the use of the Boston and Chêneau braces in AIS.Conclusion The clinical case showed effective use of the 3D GD corset as a new exponent of corsets developed on the principles offered by Chêneau to prevent surgical treatment by the time of skeletal maturity.
Algorithms and programs for automatic basing on a robotic milling processing complex
Authors: Пикалов Я.Ю. , Сарамуд М.В. , Штабель Н.В. , Ткачев С.Б. 
Published: June 2024

Представлено решение проблемы быстрой настройки рабочей системы координат роботизированного комплекса механической обработки в условиях динамично изменяющейся номенклатуры обрабатываемых изделий. Описывается система уравнений, алгоритм вычисления положения и ориентации рабочей системы координат детали относительно исходной системы координат робота, а также их реализация в виде программы автоматического базирования для двух технологических оснасток. Программа написана на языке Kuka Robot Language для робота KUKA KR90 R3100 с датчиком касания Renishaw OMP-40 и включает этапы диалогового выбора технологической оснастки и номера измеряемой базы, а также соответствующее им автоматическое измерение точек базовых поверхностей, вычисления значений линейных и угловых параметров положения рабочей системы координат и запись полученных значений в соответствующие переменные системы управления роботом. Кроме того, описываются подходы по настройке постпроцессоров для подготовки управляющих программ базирования c использованием CAM-сред. Предложенные решения в виде управляющих программ и настроенного постпроцессора успешно используются на производстве при обработке углепластиковых изделий.
The article presents a solution to the problem of quickly setting up the working coordinate system of a robotic machining complex in a dynamically changing range of machined products. The system of equations, the algorithm for calculating the position and orientation of the working coordinate system of the part relative to the initial coordinate system of the robot, as well as their implementation in the form of an automatic locating program for two technological equipment are described. The program is written in the Kuka Robot Language for the KUKA KR90 R3100 robot with a Renishaw OMP-40 touch sensor and includes the steps for the dialog selection of technological equipment and the number of the measured base, as well as the corresponding automatic measurement of points of base surfaces, calculation of the values of linear and angular position parameters working coordinate system and recording the obtained values into the corresponding variables of the robot control system. In addition, approaches to setting up postprocessors for preparing control programs based on the use of CAM environments are described. The proposed solutions in the form of control programs and a customized postprocessor are successfully used in production when processing carbon fiber products.
Theoretical usage of EMD PWVD for processing continuous signals
Authors: Алферов Н.С. , Плотников С.Б. 
Published: June 2024

Рассмотрен принцип функционирования метода EMD PWVD, предложены два алгоритма реализации EMD PWVD для преобразования непрерывных сигналов. Анализ особенностей работы методов, составляющих EMD PWVD, привел к выводу о возможном наличии артефактов, проявляющихся при использовании EMD PWVD на непрерывных сигналах. Предложен метод борьбы с ними.
The purpose of the paper is to address possible usage of EMD PWVD to process continuous signals. In order to achieve this, two possible algorithms of implementation were proposed. After analyzing inner workings of EMD PWVD it was theorized that the final result of using EMD PWVD on continuous signals may result in artifacts. After that a method to counter such artifacts was proposed.
Trends in parallelism development in computing engineering
Authors: Захаров А.И. , Брякалов Г.А. , Швец Т.С. , Петров И.С. , Петренко С.М. 
Published: June 2024

Статья посвящена рассмотрению основ параллелизма в плане его классического определения и тенденций развития применительно к средствам вычислительной техники. Детально освещены вопросы, связанные с особенностями и направлениями развития параллелизма в архитектуре компьютерных средств, в частности, в средствах суперкомпьютерной техники, а также в языках и средствах программирования. Материал статьи охватывает широкий круг вопросов и может быть полезен для специалистов, интересующихся вопросами параллелизма в плане его практического применения.
The article focuses on the consideration of the foundations of parallelism in terms of its classical definition and development trends in relation to computer technology. The issues related to the features and directions of parallelism development in the architecture of computer tools and, in particular, in supercomputing equipment, as well as in languages and programming tools are highlighted in more detail. The article covers a wide range of issues and can be useful for specialists interested in parallelism in terms of its practical application.
Attack detection models using machine learning methods
Authors: Поздняк И.С. , Макаров И.С. 
Published: June 2024

Рассматриваются некоторые способы обнаружения атак на основе машинного обучения, которые применяются для определения аномалий в готовых наборах трафика. Сделан анализ существующего положения дел в сетевой безопасности. Предложена модель обнаружения атак с использованием методов машинного обучения. Рассмотрены вопросы выбора данных для обучения классификаторов по предварительно сформированным критериям. Проведена предварительная обработка выбранных данных. Приведена классификация атак типа Brute Force и DDoS. Обучение нейронных сетей сводится к минимизации функций потерь путем подбора оптимальных весов нейронов в процессе выполнения того или иного оптимизационного итерационного алгоритма. Сделан вывод об оптимальности модели на основе решающего древа в вопросе классификации на основе логической регрессии.
Thе article discusses some machine learning-based attack detection techniques that are used to identify anomalies in ready-made traffic sets. An analysis of the current situation in network security is provided. The authors propose a model for detecting attacks using machine learning methods and consider the issues of selecting data for training classifiers according to pre-generated criteria. Pre-processing of the selected data has been carried out. The article provides a classification of Brute Force and DDoS attacks. Training neural networks consists of minimizing loss functions by selecting optimal neuron weights during the execution of one or another optimization iterative algorithm. A conclusion is made about the model optimality based on the “decision tree” in the matter of classification based on logical regression.
NARRATIVAS DE ASSOMBRAÇÃO NO MUSEU DA MEMÓRIA RONDONIENSE
Authors: Almeida Diniz Laysa , Genecy Centeno Nogueira Mara 
Published: June 2024

O objetivo central do estudo é explorar as narrativas de assombração que circulam entre os servidores do Museu da Memória Rondoniense e compreender como tais narrativas contribuíram para a criação de um imaginário popular em torno do prédio que hoje abriga o acervo documental, fotográfico e arqueológico do estado de Rondônia. A pesquisa foi desenvolvida sob abordagem qualitativa, com aplicação de entrevistas individuais junto a servidores do Museu, a fim de coletar histórias de assombração vinculadas ao prédio. A análise dos dados se apoia em diversas referências, incluindo-se: Tim Edensor (2005), que propõe uma abordagem para entender como os espaços históricos promovem experiências "entre-mundos"; Mara Nogueira e Sônia Sampaio (2020) e Gilberto Freyre (2015), que discutem as narrativas de assombração em diferentes contextos, incluindo-se a cidade de Porto Velho e o Recife Velho; e Peter Burke (2005), que defende a importância da história cultural para explorar essas narrativas.
Pengembangan Kelas Edukasi di Gubuk Pustaka Ndalung Desa Ajung Kabupaten Jember
Authors: Dirgantara Yolan , A’yun Lintang Qurota , Istana Audio Brillian , Bella Permata Sari  , Najmi Fatihus Shidqi  , Lailatul Hasanah  , Nadia Ramadani Firmansyah  , Shinta Kusuma Wati  , Kartika Sari Vega 
Published: June 2024

Pengembangan dunia pendidikan menjadi bagian yang sangat penting dalam menghasilkan sumber daya manusia yang berkompeten, cerdas, kreatif dan berbudi pekerti luhur di era modern ini. Tim bekerja sama dengan Gubuk Pustaka Ndalung memberikan pendampingan kelas edukasi bagi anak-anak di Desa Ajung. Tujuan kegiatan ini adalah memberikan edukasi untuk meningkatkan pengetahuan melalui kegiatan yang menyenangkan. Jenis kelas edukasi yang dilakukan adalah kelas prakarya, kesehatan, sains dan pertanian. Sasaran kegiatan adalah anak-anak PAUD, TK, SD dan SMP. Kegiatan ini diikuti 30 peserta dari setiap kelas. Berdasarkan hasil kuisioner, peserta sangat senang (55%) dan senang (30%) dengan adanya kegiatan ini. Kesuksesan kegiatan ini dipengaruhi beberapa faktor diantaranya mendapat dukungan penuh dari pendiri Gubuk Pustaka Ndalung, konsep pembelajaran yang menarik, dan antusiasme dari peserta.

Kata Kunci: Kelas edukasi, Anak-anak, Gubuk Pustaka Ndalung
Inhibition of glutaminolysis alone and in combination with HDAC inhibitor has anti-myeloma therapeutic effects
Authors: Okabe Seiichi , Tanaka Yuko , Moriyama Mitsuru , Gotoh Akihiko 
Published: June 2024

Aim: This study aimed to investigate drug candidates and their efficacy in treating refractory multiple myeloma (MM) despite significant therapeutic advances and the introduction of novel agents. Our study focused on how myeloma cells mediate the metabolic pathways essential for survival. Therefore, we examined the role of glutaminolysis in this process.
Methods: We investigated the role of glutaminolysis in myeloma cell growth. In addition, we analyzed the ability of CB-839 (telaglenastat), a glutaminase (GLS) inhibitor, to suppress myeloma cell proliferation and enhance the sensitivity to histone deacetylase (HDAC) inhibitors.
Results: Glutamate deprivation significantly reduced MM cell proliferation. We observed an upregulation of GLS1 expression in MM cell lines compared to that in normal controls. CB-839 inhibits MM cell proliferation in a dose-dependent manner, resulting in enhanced cytotoxicity. Additionally, intracellular α-ketoglutarate and nicotinamide adenine dinucleotide phosphate levels decreased after CB-839 administration. Combining panobinostat with CB-839 resulted in enhanced cytotoxicity and increased caspase 3/7 activity. Cells transfected with GLS shRNA exhibited reduced cell viability and elevated sub-G1 phase according to cell cycle analysis results. Compared to control cells, these cells also showed increased sensitivity to panobinostat.
Conclusion: Glutaminolysis contributes to the viability of MM cells, and the GLS inhibitor CB-839 has been proven to be an effective treatment for enhancing the cytotoxic effect of HDAC inhibition. These results are clinically relevant and suggest that CB-839 is a potential therapeutic candidate for patients with MM.
WITHDRAWN: Geoelectric Structure of Yalova-termal Town Bymagnetotelluric Data, Northwestern Turkey
Authors: Sevim Fatih , Pekşen Ertan , Dikbaş Aynur 
Published: June 2024

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Knowledge, attitude, and practice of e-cigarette use among undergraduate students: A comparative study between China and Indonesia
Authors: Hartono Ronald , Rui Deng , Ying Chen , Fang Yan Chao , Ting Ma Bo , Qi Deng Ya , Jia Sun Yi , Pan Li , Dao Yu Ye 
Published: June 2024

Abstract

Background
The health risks associated with e-cigarettes are currently the focus of tobacco control efforts and public health initiatives. Given that China and Indonesia have the highest rates of adult smoking worldwide, it is imperative to gain a comprehensive understanding of e-cigarette prevalence among college students in these two nations.
Methods
From May to June 2023, a random sampling method was employed to conduct an online questionnaire survey among college students in three universities located in Kunming (China) and Jakarta (Indonesia) respectively. The chi-square test was utilized for comparing the rates/ratios, while binary logistic regression analysis was applied to examine the influencing factors of e-cigarette knowledge, attitude, and practice.
Results
A total of 1327 individuals were included in the investigation. The proportion of Indonesian students (75.6%) with a high level of e-cigarette knowledge was lower than that observed among Chinese students (87.4%) (χ2 = 29.697, P < 0.001). Additionally, the prevalence of e-cigarette use among Indonesian students (9.4%) was higher compared to their Chinese counterparts (3.0%) (χ2 = 22.320, P < 0.001). Binary logistic regression analysis revealed that age, place of residence, major, gender, as well as friends' and family members' e-cigarette use significantly influenced knowledge levels and attitudes towards e-cigarettes in both countries (P < 0.05).
Conclusion
Despite the positive knowledge, attitudes, and practices towards e-cigarettes among undergraduate students in both countries, a notable knowledge gap exists concerning the harmful effects of e-cigarettes. In comparison, Chinese students exhibit a better comprehension of e-cigarette knowledge and demonstrate lower usage rates, suggesting that heightened awareness plays a favorable role in preventing e-cigarette use. Furthermore, it becomes imperative for policymakers and health educators to focus on specific factors such as the influence of close friends and family members, as well as the residency area.