bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of metabolic syndrome among patients with hepatocellular carcinoma of different etiologies: a retrospective study
Authors: Yang Da-Long , Liu Shao-Ping , Wang Hong-Liang , Li Jian-Rong , Su Jia-Yong , Li Min-Jun , Teng Yu-Xian , Deng Zhu-Jian , Li Zhong-Hai , Huang Jian-Li , Guo Ping-Ping , Ma Liang , Li Zhen-Zhen , Zhong Jian-Hong 
Published: May 2024

Abstract
Aims
This study compared the prevalences of metabolic syndrome and of cardiac or kidney comorbidities among patients with hepatocellular carcinoma (HCC) associated with metabolic dysfunction-related fatty liver disease (MAFLD), chronic infection with hepatitis B or C virus (HBV or HCV), or the combination of MAFLD and chronic HBV infection.

Methods
Medical records were retrospectively analyzed for patients with HCC who underwent hepatectomy between March 2013 and March 2023. Patients with HCC of different etiologies were compared in terms of their clinicodemographic characteristics and laboratory data before surgery.

Results
Of the 2422 patients, 1,822 (75.2%) were chronically infected with HBV without MAFLD and HCV, 415 (17.2%) had concurrent MAFLD and chronic HBV infection but no HCV infection, 121 (5.0%) had MAFLD without hepatitis virus infection, and 64 (2.6%) were chronically infected with HCV in the presence or absence of MAFLD and HBV infection. Compared to patients chronically infected with HBV without MAFLD and HCV, those with MAFLD but no hepatitis virus infection showed significantly lower prevalence of cirrhosis, ascites, portal hypertension, alpha-fetoprotein concentration ≥ 400 ng/mL, tumor size > 5 cm, multinodular tumors and microvascular invasion. Conversely, they showed significantly higher prevalence of metabolic syndrome, hypertension, type 2 diabetes, abdominal obesity, history of cardiovascular disease, T-wave alterations, hypertriglyceridemia and hyperuricemia, as well as higher risk of arteriosclerotic cardiovascular disease. Compared to patients with MAFLD but no hepatitis virus infection, those with concurrent MAFLD and chronic infection with HBV showed significantly higher prevalence of cirrhosis, ascites and portal hypertension, but significantly lower prevalence of hypertension and history of cardiovascular disease. Compared to patients with other etiologies, those chronically infected with HCV in the presence or absence of MAFLD and HBV infection, showed significantly higher prevalence of cirrhosis, portal hypertension, ascites, and esophagogastric varices.

Conclusion
Patients with HCC associated with MAFLD tend to have a background of less severe liver disease than those with HCC of other etiologies, but they may be more likely to suffer metabolic syndrome or comorbidities affecting the heart or kidneys.
N, N-Dimethyltryptamine, a natural hallucinogen, ameliorates Alzheimer’s disease by restoring neuronal Sigma-1 receptor-mediated endoplasmic reticulum-mitochondria crosstalk
Authors: Cheng Dan , Lei Zhuo-Gui , Chu Kin , Lam Oi Jin Honey , Chiang Chun Yuan , Zhang Zhang-Jin 
Published: May 2024

Abstract
Background
Aberrant neuronal Sigma-1 receptor (Sig-1r)-mediated endoplasmic reticulum (ER)- mitochondria signaling plays a key role in the neuronal cytopathology of Alzheimer’s disease (AD). The natural psychedelic N, N-dimethyltryptamine (DMT) is a Sig-1r agonist that may have the anti-AD potential through protecting neuronal ER-mitochondrial interplay.

Methods
3×TG-AD transgenic mice were administered with chronic DMT (2 mg/kg) for 3 weeks and then performed water maze test. The Aβ accumulation in the mice brain were determined. The Sig-1r level upon DMT treatment was tested. The effect of DMT on the ER-mitochondrial contacts site and multiple mitochondria-associated membrane (MAM)-associated proteins were examined. The effect of DMT on calcium transport between ER and mitochondria and the mitochondrial function were also evaluated.

Results
chronic DMT (2 mg/kg) markedly alleviated cognitive impairment of 3×TG-AD mice. In parallel, it largely diminished Aβ accumulation in the hippocampus and prefrontal cortex. DMT restored the decreased Sig-1r levels of 3×TG-AD transgenic mice. The hallucinogen reinstated the expression of multiple MAM-associated proteins in the brain of 3×TG-AD mice. DMT also prevented physical contact and calcium dynamic between the two organelles in in vitro and in vivo pathological circumstances. DMT modulated oxidative phosphorylation (OXPHOS) and ATP synthase in the in vitro model of AD.

Conclusion
The anti-AD effects of DMT are associated with its protection of neuronal ER-mitochondria crosstalk via the activation of Sig-1r. DMT has the potential to serve as a novel preventive and therapeutic agent against AD.
Evaluation of features and channels of electroencephalographic signals for biometric systems
Authors: Carrión-Ojeda Dustin , Martínez-Arias Paola , Fonseca-Delgado Rigoberto , Pineda Israel , Mejía-Vallejo Héctor 
Published: May 2024

AbstractBiometric systems are essential tools in modern society where most of our personal information lives in digital form. Although there is a significant variety of biometrics, electroencephalogram (EEG) signals are a useful technique to guarantee that the person is alive, they are universal, and not falsifiable. Nevertheless, EEG processing needs to address some challenges to become a viable technique to build production-ready biometric systems. These challenges include the adequate selection of features and channels that maximize the quality of the results and optimize resources. This work provides an analysis of which are the most important features and channels for the correct operation of a biometric system. The experimental analysis worked with two datasets and evaluated 19 features belonging to three groups, wavelet-based, spectral, and complexity. Five classifiers were trained: multilayer perceptron, AdaBoost, random forest, support vector machine, and K-nearest neighbors. The results found that the best feature for developing a biometric system is the standard deviation extracted from the coefficients of a three-level discrete wavelet transform. Additionally, the experimental results with the two datasets showed that the proposed method for channel selection can reduce the necessary number of channels while maintaining its performance. Our results, from one of the datasets, showed a reduction of 21 channels (from 32 to 11) and indicated that the best channels to develop biometric systems seem to be those located on the central area of the scalp.
Mi-Go: tool which uses YouTube as data source for evaluating general-purpose speech recognition machine learning models
Authors: Wojnar Tomasz , Hryszko Jarosław , Roman Adam 
Published: May 2024

AbstractThis article introduces Mi-Go, a tool aimed at evaluating the performance and adaptability of general-purpose speech recognition machine learning models across diverse real-world scenarios. The tool leverages YouTube as a rich and continuously updated data source, accounting for multiple languages, accents, dialects, speaking styles, and audio quality levels. To demonstrate the effectiveness of the tool, an experiment was conducted, by using Mi-Go to evaluate state-of-the-art automatic speech recognition machine learning models. The evaluation involved a total of 141 randomly selected YouTube videos. The results underscore the utility of YouTube as a valuable data source for evaluation of speech recognition models, ensuring their robustness, accuracy, and adaptability to diverse languages and acoustic conditions. Additionally, by contrasting the machine-generated transcriptions against human-made subtitles, the Mi-Go tool can help pinpoint potential misuse of YouTube subtitles, like search engine optimization.
Neurophysiological insights into sequential decision-making: exploring the secretary problem through ERPs and TBR dynamics
Authors: Mizrahi Dor , Laufer Ilan , Zuckerman Inon 
Published: May 2024

AbstractDecision-making under uncertainty, a cornerstone of human cognition, is encapsulated by the “secretary problem” in optimal stopping theory. Our study examines this decision-making challenge, where participants are required to sequentially evaluate and make irreversible choices under conditions that simulate cognitive overload. We probed neurophysiological responses by engaging 27 students in a secretary problem simulation while undergoing EEG monitoring, focusing on Event-Related Potentials (ERPs) P200 and P400, and Theta to Beta Ratio (TBR) dynamics.Results revealed a nuanced pattern: the P200 component’s amplitude declined from the initial to the middle offers, suggesting a diminishing attention span as participants grew accustomed to the task. This attenuation reversed at the final offer, indicating a heightened cognitive processing as the task concluded. In contrast, the P400 component’s amplitude peaked at the middle offer, hinting at increased cognitive evaluation, and tapered off at the final decision. Additionally, TBR dynamics illustrated a fluctuation in attentional control and emotional regulation throughout the decision-making sequence, enhancing our understanding of the cognitive strategies employed.The research elucidates the dynamic interplay of cognitive processes in high-stakes environments, with neurophysiological markers fluctuating significantly as participants navigated sequential choices. By correlating these fluctuations with decision-making behavior, we provide insights into the evolving strategies from heightened alertness to strategic evaluation. Our findings offer insights that could inform the use of neurophysiological data in the development of decision-making frameworks, potentially contributing to the practical application of cognitive research in real-life contexts.
Detection and recognition of Chinese porcelain inlay images of traditional Lingnan architectural decoration based on YOLOv4 technology
Authors: Li Yanyu , Zhao Mingyi , Mao Jingyi , Chen Yile , Zheng Liang , Yan Lina 
Published: May 2024

Abstract
With the rapid development of machine learning technology, it has become possible to automatically identify cultural heritage elements in traditional buildings. This research aimed to develop a machine learning model based on the YOLOv4 architecture to identify the traditional Chinese porcelain inlay pattern in the Lingnan region. The researchers collected and annotated a large quantity of Lingnan Chinese porcelain inlay image data and then used these data to train the studied model. The research results show that (1) the model in this study was specifically adjusted to effectively identify a variety of Chinese porcelain inlay pattern types, including traditional patterns such as plum blossoms and camellias. (2) In the 116th epoch, the model showed excellent generalization ability, and the verification loss reached the lowest value of 0.88. The lowest training loss in the 195th epoch was 0.99, indicating that the model reached an optimal balance point for both recognition accuracy and processing speed. (3) By comparing different models for detecting Chinese porcelain inlay images across 581 pictures, our YOLOv4 model demonstrated greater accuracy in most classification tasks than did the YOLOv8 model, especially in the classification of chrysanthemums, where it achieved an accuracy rate of 87.5%, significantly outperforming YOLOv8 by 58.82%. However, the study also revealed that under certain conditions, such as detecting apples and pears in low-light environments, YOLOv8 showed a lower missing data rate, highlighting the limitations of our model in dealing with complex detection conditions.
Conversion surgery for gastric remnant cancer with liver metastasis after nivolumab combination chemotherapy achieving pathological complete response: a case report and literature review
Authors: Katsumata Kaori , Morimoto Yosuke , Aoyama Junya , Yamada Toru , Katsuki Yusuke , Nishiyama Ryo , Egawa Tomohisa 
Published: May 2024

Abstract
Background
Nivolumab combination chemotherapy has recently emerged as a potential first-line treatment for patients with unresectable or metastatic gastric cancer (GC). Further research has indicated that R0 resection by conversion surgery could be an effective treatment strategy to improve overall survival. However, there have been limited reports on the successful application of conversion surgery following combination chemotherapy achieving pathological complete response (pCR) in cases of advanced gastric remnant cancer with liver metastasis. Here, we present a case of long-term survival in a patient who underwent this treatment.

Case presentation
A 54-year-old man was initially referred to our department for treatment of stage III (cT3N1M0) gastric cancer where he underwent laparoscopic distal gastrectomy and D2 lymph node dissection. After a year of uneventful follow-up, the patient was diagnosed with a tumor in the gastric remnant combined with liver metastasis, resulting in a diagnosis of stage IV (cT3N0M1) gastric remnant cancer. Subsequently, the patient was treated with four cycles of TS-1, Oxaliplatin, and Nivolumab as the first-line regimen. Remarkably, both the remnant tumor and liver metastasis exhibited significant shrinkage, and no new lesions were found. Given this response, conversion surgery was performed to achieve complete resection of the remnant gastric cancer and liver metastasis, followed by laparoscopic remnant gastrectomy and partial hepatectomy. Pathological examination revealed the absence of residual carcinoma cells and lymph node metastases. Postoperatively, the patient was treated with adjuvant chemotherapy with S-1 for 1 year, and survived without recurrence for 18 months after conversion surgery.

Conclusions
Nivolumab combination chemotherapy shows promise as a clinically beneficial treatment approach for gastric remnant cancer with liver metastasis, particularly when pCR can be achieved following conversion surgery.
Trial of Electronic Medical Record Integrated Next-Generation Sequencing Ordering in Veterans Affairs Cancer Care
Authors: Stoeckle James H. , Poland Sarah G. , Maynard Hannah , Roman Stefanie D. , Mettman Daniel , Makarov Danil V. , Sherman Scott , Becker Daniel J. 
Published: May 2024

PURPOSE Previous studies document underuse of next-generation sequencing (NGS). We examined the impact to oncology care for veterans of incorporating NGS ordering into the Veterans Affairs (VA) electronic medical record (EMR) at two New York City VA Medical Centers. METHODS We identified patients with non–small cell lung cancer and prostate cancer with oncology clinic visits and NGS testing indications between January and December 2021. Patients were divided into external ordering (EO) with visits before we implemented an EMR ordering system for NGS in July 2021, and internal ordering (IO) with visits after this date. The primary outcome was proportion of NGS testing performed in EO versus IO groups. Secondary outcomes were time between metastatic disease diagnosis to receipt of test by vendor, time of metastatic diagnosis to result, and proportion of testing by race. RESULTS A total of 168 patients were identified, 116 EO and 52 IO patients. Between IO and EO periods, testing significantly increased from 52% to 87% ( P ≤ .01); it was conducted more quickly, with time from metastatic diagnosis to sample receipt by the NGS vendor improving to median 37 days from 299 days ( P = .03); and the time from documented metastatic disease to a test result improved to median 56 days from 309 days ( P = .03). The proportion of tissue received by the vendor was not significantly different between the two groups. There were no significant differences in testing according to self-reported race. CONCLUSION Integration of NGS ordering in the EMR led to increased proportion and speed of testing for a vulnerable patient population served by the country's largest health system.
Surgical management of proximal femoral unicameral bone cyst in children
Authors: Maximen Julien , Jeantet Rose-Elisabeth , Violas Philippe 
Published: May 2024

AimsThe aim of this study is to evaluate the surgical treatment with the best healing rate for patients with proximal femoral unicameral bone cysts (UBCs) after initial surgery, and to determine which procedure has the lowest adverse event burden during follow-up.MethodsThis multicentre retrospective study was conducted in 20 tertiary paediatric hospitals in France, Belgium, and Switzerland, and included patients aged < 16 years admitted for UBC treatment in the proximal femur from January 1995 to December 2017. UBCs were divided into seven groups based on the index treatment, which included elastic stable intramedullary nail (ESIN) insertion with or without percutaneous injection or grafting, percutaneous injection alone, curettage and grafting alone, and insertion of other orthopaedic hardware with or without curettage.ResultsA total of 201 patients were included in the study. The mean age at diagnosis was 8.7 years (SD 3.9); 77% (n = 156) were male. The mean follow-up was 9.4 years (SD 3.9). ESIN insertion without complementary procedure had a 67% UBC healing rate after the first operation (vs 30% with percutaneous injection alone (p = 0.027), 43% with curettage and grafting (p = 0.064), and 21% with insertion of other hardware combined with curettage (p < 0.001) or 36% alone (p = 0.014)). ESIN insertion with percutaneous injection presented a 79% healing rate, higher than percutaneous injection alone (p = 0.017), curettage and grafting (p = 0.028), and insertion of other hardware combined with curettage (p < 0.001) or alone (p = 0.014). Patients who underwent ESIN insertion with curettage had a 53% healing rate, higher than insertion of other hardware combined with curettage (p = 0.009). The overall rate of postoperative complications was 25% and did not differ between groups (p = 0.228). A total of 32 limb length discrepancies were identified.ConclusionESIN insertion, either alone or combined with percutaneous injection or curettage and grafting, may offer higher healing rates than other operative procedures. Limb length discrepancy remains a major concern, and might be partly explained by the cyst’s location and the consequence of surgery. Therefore, providing information about this risk is crucial.Cite this article: Bone Joint J 2024;106-B(5):508–514.
Virtual biomechanical assessment of porous tantalum and custom triflange components in the treatment of patients with acetabular defects and pelvic discontinuity
Authors: Callary Stuart A. , Broekhuis Demien , Barends Jessica , Ramasamy Boopalan , Nelissen Rob G. H. H. , Solomon Lucian B. , Kaptein Bart L. 
Published: May 2024

AimsThe aim of this study was to compare the biomechanical models of two frequently used techniques for reconstructing severe acetabular defects with pelvic discontinuity in revision total hip arthroplasty (THA) – the Trabecular Metal Acetabular Revision System (TMARS) and custom triflange acetabular components (CTACs) – using virtual modelling.MethodsPre- and postoperative CT scans from ten patients who underwent revision with the TMARS for a Paprosky IIIB acetabular defect with pelvic discontinuity were retrospectively collated. Computer models of a CTAC implant were designed from the preoperative CT scans of these patients. Computer models of the TMARS reconstruction were segmented from postoperative CT scans using a semi-automated method. The amount of bone removed, the implant-bone apposition that was achieved, and the restoration of the centre of rotation of the hip were compared between all the actual TMARS and the virtual CTAC implants.ResultsThe median amount of bone removed for TMARS reconstructions was significantly greater than for CTAC implants (9.07 cm3 (interquartile range (IQR) 5.86 to 21.42) vs 1.16 cm3 (IQR 0.42 to 3.53) (p = 0.004). There was no significant difference between the median overall implant-bone apposition between TMARS reconstructions and CTAC implants (54.8 cm2 (IQR 28.2 to 82.3) vs 56.6 cm2 (IQR 40.6 to 69.7) (p = 0.683). However, there was significantly more implant-bone apposition within the residual acetabulum (45.2 cm2 (IQR 28.2 to 72.4) vs 25.5 cm2 (IQR 12.8 to 44.1) (p = 0.001) and conversely significantly less apposition with the outer cortex of the pelvis for TMARS implants compared with CTAC reconstructions (0 cm2 (IQR 0 to 13.1) vs 23.2 cm2 (IQR 16.4 to 30.6) (p = 0.009). The mean centre of rotation of the hip of TMARS reconstructions differed by a mean of 11.1 mm (3 to 28) compared with CTAC implants.ConclusionIn using TMARS, more bone is removed, thus achieving more implant-bone apposition within the residual acetabular bone. In CTAC implants, the amount of bone removed is minimal, while the implant-bone apposition is more evenly distributed between the residual acetabulum and the outer cortex of the pelvis. The differences suggest that these implants used to treat pelvic discontinuity might achieve short- and long-term stability through different biomechanical mechanisms.Cite this article: Bone Joint J 2024;106-B(5 Supple B):74–81.
Incidence, treatment, and outcomes of modern dual-mobility intraprosthetic dissociations
Authors: Mallett Katherine E. , Guarin Perez Sergio F. , Taunton Michael J. , Sierra Rafael J. 
Published: May 2024

AimsDual-mobility (DM) components are increasingly used to prevent and treat dislocation after total hip arthroplasty (THA). Intraprosthetic dissociation (IPD) is a rare complication of DM that is believed to have decreased with contemporary implants. This study aimed to report incidence, treatment, and outcomes of contemporary DM IPD.MethodsA total of 1,453 DM components were implanted at a single academic institution between January 2010 and December 2021: 695 in primary and 758 in revision THA. Of these, 49 presented with a dislocation of the large DM head and five presented with an IPD. At the time of closed reduction of the large DM dislocation, six additional IPDs occurred. The mean age was 64 years (SD 9.6), 54.5% were female (n = 6), and mean follow-up was 4.2 years (SD 1.8). Of the 11 IPDs, seven had a history of instability, five had abductor insufficiency, four had prior lumbar fusion, and two were conversions for failed fracture management.ResultsThe incidence of IPD was 0.76%. Of the 11 IPDs, ten were missed either at presentation or after attempted reduction. All ten patients with a missed IPD were discharged with a presumed reduction. The mean time from IPD to surgical treatment was three weeks (0 to 23). One patient died after IPD prior to revision. Of the ten remaining hips with IPD, the DM head was exchanged in two, four underwent acetabular revision with DM exchange, and four were revised to a constrained liner. Of these, five (50%) underwent reoperation at a mean 1.8 years (SD 0.73), including one additional acetabular revision. No patients who underwent initial acetabular revision for IPD treatment required subsequent reoperation.ConclusionThe overall rate of IPD was low at 0.76%. It is essential to identify an IPD on radiographs as the majority were missed at presentation or after iatrogenic dissociation. Surgeons should consider acetabular revision for IPD to allow conversion to a larger DM head, and take care to remove impinging structures that may increase the risk of subsequent failure.Cite this article: Bone Joint J 2024;106-B(5 Supple B):98–104.