bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of human mobility on the citywide transmission dynamics of 18 respiratory viruses in pre- and post-COVID-19 pandemic years
Authors: Perofsky Amanda C. , Hansen Chelsea L. , Burstein Roy , Boyle Shanda , Prentice Robin , Marshall Cooper , Reinhart David , Capodanno Ben , Truong Melissa , Schwabe-Fry Kristen , Kuchta Kayla , Pfau Brian , Acker Zack , Lee Jover , Sibley Thomas R. , McDermot Evan , Rodriguez-Salas Leslie , Stone Jeremy , Gamboa Luis , Han Peter D. , Adler Amanda , Waghmare Alpana , Jackson Michael L. , Famulare Michael , Shendure Jay , Bedford Trevor , Chu Helen Y. , Englund Janet A. , Starita Lea M. , Viboud Cécile 
Published: May 2024

AbstractMany studies have used mobile device location data to model SARS-CoV-2 dynamics, yet relationships between mobility behavior and endemic respiratory pathogens are less understood. We studied the effects of population mobility on the transmission of 17 endemic viruses and SARS-CoV-2 in Seattle over a 4-year period, 2018-2022. Before 2020, visits to schools and daycares, within-city mixing, and visitor inflow preceded or coincided with seasonal outbreaks of endemic viruses. Pathogen circulation dropped substantially after the initiation of COVID-19 stay-at-home orders in March 2020. During this period, mobility was a positive, leading indicator of transmission of all endemic viruses and lagging and negatively correlated with SARS-CoV-2 activity. Mobility was briefly predictive of SARS-CoV-2 transmission when restrictions relaxed but associations weakened in subsequent waves. The rebound of endemic viruses was heterogeneously timed but exhibited stronger, longer-lasting relationships with mobility than SARS-CoV-2. Overall, mobility is most predictive of respiratory virus transmission during periods of dramatic behavioral change and at the beginning of epidemic waves.
Ion pair sites for efficient electrochemical extraction of uranium in real nuclear wastewater
Authors: Lin Tao , Chen Tao , Jiao Chi , Zhang Haoyu , Hou Kai , Jin Hongxiang , Liu Yan , Zhu Wenkun , He Rong 
Published: May 2024

AbstractElectrochemical uranium extraction from nuclear wastewater represents an emerging strategy for recycling uranium resources. However, in nuclear fuel production which generates the majority of uranium-containing nuclear wastewater, fluoride ion (F−) co-exists with uranyl (UO22+), resulting in the complex species of UO2Fx and thus decreasing extraction efficiency. Herein, we construct Tiδ+-PO43− ion pair extraction sites in Ti(OH)PO4 for efficient electrochemical uranium extraction in wastewater from nuclear fuel production. These sites selectively bind with UO2Fx through the combined Ti-F and multiple O-U-O bonds. In the uranium extraction, the uranium species undergo a crystalline transition from U3O7 to K3UO2F5. In real nuclear wastewater, the uranium is electrochemically extracted with a high efficiency of 99.6% and finally purified as uranium oxide powder, corresponding to an extraction capacity of 6829 mg g−1 without saturation. This work paves an efficient way for electrochemical uranium recycling in real wastewater of nuclear production.
Efficient multimode Wigner tomography
Authors: He Kevin , Yuan Ming , Wong Yat , Chakram Srivatsan , Seif Alireza , Jiang Liang , Schuster David I. 
Published: May 2024

AbstractAdvancements in quantum system lifetimes and control have enabled the creation of increasingly complex quantum states, such as those on multiple bosonic cavity modes. When characterizing these states, traditional tomography scales exponentially with the number of modes in both computational and experimental measurement requirement, which becomes prohibitive as the system size increases. Here, we implement a state reconstruction method whose sampling requirement instead scales polynomially with system size, and thus mode number, for states that can be represented within such a polynomial subspace. We demonstrate this improved scaling with Wigner tomography of multimode entangled W states of up to 4 modes on a 3D circuit quantum electrodynamics (cQED) system. This approach performs similarly in efficiency to existing matrix inversion methods for 2 modes, and demonstrates a noticeable improvement for 3 and 4 modes, with even greater theoretical gains at higher mode numbers.
FAIR assessment of nanosafety data reusability with community standards
Authors: Ammar Ammar , Evelo Chris , Willighagen Egon 
Published: May 2024

AbstractNanomaterials hold great promise for improving our society, and it is crucial to understand their effects on biological systems in order to enhance their properties and ensure their safety. However, the lack of consistency in experimental reporting, the absence of universally accepted machine-readable metadata standards, and the challenge of combining such standards hamper the reusability of previously produced data for risk assessment. Fortunately, the research community has responded to these challenges by developing minimum reporting standards that address several of these issues. By converting twelve published minimum reporting standards into a machine-readable representation using FAIR maturity indicators, we have created a machine-friendly approach to annotate and assess datasets’ reusability according to those standards. Furthermore, our NanoSafety Data Reusability Assessment (NSDRA) framework includes a metadata generator web application that can be integrated into experimental data management, and a new web application that can summarize the reusability of nanosafety datasets for one or more subsets of maturity indicators, tailored to specific computational risk assessment use cases. This approach enhances the transparency, communication, and reusability of experimental data and metadata. With this improved FAIR approach, we can facilitate the reuse of nanosafety research for exploration, toxicity prediction, and regulation, thereby advancing the field and benefiting society as a whole.
Tensile testing data of additive manufactured ASTM D638 standard specimens with embedded internal geometrical features
Authors: AbouelNour Youssef , Rakauskas Nick , Naquila Gabrielle , Gupta Nikhil 
Published: May 2024

AbstractAdditive manufacturing (AM) is now widely used for research and industrial production. The benchmark data for mechanical properties of additively manufactured specimens is very useful for many communities. This data article presents a tensile testing dataset of ASTM D638 size specimens without and with embedded internal geometrical features printed using polylactic acid (PLA) in a Fused Filament Fabrication (FFF) additive manufacturing process. The added features can mimic defects of various shapes and sizes. This work is a supplement to the published research article Assisted defect detection by in-process monitoring of additive manufacturing using optical imaging and infrared thermography (Additive Manufacturing, 2023, 103483). The printed specimens were tensile tested. Stress-strain graphs were developed and used to calculate the mechanical properties such as ultimate tensile strength (UTS) and strain at UTS. The mechanical properties, the correlations between mechanical properties and size, shape and location of geometrical features (defects), and the trends in mechanical properties can be useful in benchmarking the results of other researchers.
Factors associated with physical inactivity among Palestinians with type 2 diabetes mellitus treated in resource-limited settings
Authors: Shawahna Ramzi , Jaber Mohammad , Zmiro Arob , Kashkoush Sewar 
Published: May 2024

AbstractThis study determined the prevalence and the associated factors with meeting the recommended amount of physical activity among type 2 diabetes mellitus (T2DM) patients receiving care in resource-limited settings of the West Bank of Palestine. Physical activity was assessed using the World Health Organization’s Global Physical Activity Questionnaire. Associations were examined using multivariate logistic regression. Of the 302 patients included, 117 (38.7%) met the recommended amount of physical activity. Being younger than 58 years [aOR = 2.1 (95% CI 1.0–4.3], were employed [aOR = 2.3 (95% CI 1.1–4.9)], had high income [aOR = 3.9 (95% CI 1.3–11.9)], had thought that physical activity was crucial for T2DM patients [aOR = 32.7 (95% CI 3.9–275.5)], did not have comorbidities [aOR = 2.2 (95% CI 1.1–4.4)], had normal weight [aOR = 2.8 (95% CI 1.3–6.0)], and those who were overweight [aOR = 2.6 (95% CI 1.1–6.0)] were more likely to meet the recommended amount of physical activity compared to the patients who were 58 years or older, had low income, did not think that physical activity was crucial for T2DM patients, had comorbidities, and were obese, respectively. There is a need to increase physical activity among T2DM patients in resource limited settings.
Reanalysis of cluster randomised trial data to account for exposure misclassification using a per-protocol and complier-restricted approach
Authors: Dufault Suzanne M. , Tanamas Stephanie K. , Indriani Citra , Ahmad Riris Andono , Utarini Adi , Jewell Nicholas P. , Simmons Cameron P. , Anders Katherine L. 
Published: May 2024

AbstractThe intention-to-treat (ITT) analysis of the Applying Wolbachia to Eliminate Dengue (AWED) trial estimated a protective efficacy of 77.1% for participants resident in areas randomised to receive releases of wMel-infected Aedes aegypti mosquitoes, an emerging dengue preventive intervention. The limiting assumptions of ITT analyses in cluster randomised trials and the mobility of mosquitoes and humans across cluster boundaries indicate the primary analysis is likely to underestimate the full public health benefit. Using spatiotemporally-resolved data on the distribution of Wolbachia mosquitoes and on the mobility of AWED participants (n = 6306), we perform complier-restricted and per-protocol re-examinations of the efficacy of the Wolbachia intervention. Increased intervention efficacy was estimated in all analyses by the refined exposure measures. The complier-restricted analysis returned an estimated efficacy of 80.7% (95% CI 65.9, 89.0) and the per-protocol analysis estimated 82.7% (71.7, 88.4) efficacy when comparing participants with an estimated wMel exposure of $$\ge$$
≥
80% compared to those with <20%. These reanalyses demonstrate how human and mosquito movement can lead to underestimation of intervention effects in trials of vector interventions and indicate that the protective efficacy of Wolbachia is even higher than reported in the primary trial results.
Multi-scale coupled attention for visual object detection
Authors: Li Fei , Yan Hongping , Shi Linsu 
Published: May 2024

AbstractThe application of deep neural network has achieved remarkable success in object detection. However, the network structures should be still evolved consistently and tuned finely to acquire better performance. This gears to the continuous demands on high performance in those complex scenes, where multi-scale objects to be detected are located here and there. To this end, this paper proposes a network structure called Multi-Scale Coupled Attention (MSCA) under the framework of self-attention learning with methodologies of importance assessment. Architecturally, it consists of a Multi-Scale Coupled Channel Attention (MSCCA) module, and a Multi-Scale Coupled Spatial Attention (MSCSA) module. Specifically, the MSCCA module is developed to achieve the goal of self-attention learning linearly on the multi-scale channels. In parallel, the MSCSA module is constructed to achieve this goal nonlinearly on the multi-scale spatial grids. The MSCCA and MSSCA modules can be connected together into a sequence, which can be used as a plugin to develop end-to-end learning models for object detection. Finally, our proposed network is compared on two public datasets with 13 classical or state-of-the-art models, including the Faster R-CNN, Cascade R-CNN, RetinaNet, SSD, PP-YOLO, YOLO v3, YOLO v5, YOLO v7, YOLOX, DETR, conditional DETR, UP-DETR and FP-DETR. Comparative experimental results with numerical scores, the ablation study, and the performance behaviour all demonstrate the effectiveness of our proposed model.
Multi-omic analysis identifies hypoalbuminemia as independent biomarker of poor outcome upon PD-1 blockade in metastatic melanoma
Authors: Leek Lindsay V. M. , Notohardjo Jessica C. L. , de Joode Karlijn , Velker Eline L. , Haanen John B. A. G. , Suijkerbuijk Karijn P. M. , Aarts Maureen J. B. , de Groot Jan Willem B. , Kapiteijn Ellen , van den Berkmortel Franchette W. P. J. , Westgeest Hans M. , de Gruijl Tanja D. , Retel Valesca P. , Cuppen Edwin , van der Veldt Astrid A. M. , Labots Mariette , Voest Emile E. , van de Haar Joris , van den Eertwegh Alfons J. M. 
Published: May 2024

AbstractWe evaluated the prognostic value of hypoalbuminemia in context of various biomarkers at baseline, including clinical, genomic, transcriptomic, and blood-based markers, in patients with metastatic melanoma treated with anti-PD-1 monotherapy or anti-PD-1/anti-CTLA-4 combination therapy (n = 178). An independent validation cohort (n = 79) was used to validate the performance of hypoalbuminemia compared to serum LDH (lactate dehydrogenase) levels. Pre-treatment hypoalbuminemia emerged as the strongest predictor of poor outcome for both OS (HR = 4.01, 95% CI 2.10–7.67, Cox P = 2.63e−05) and PFS (HR = 3.72, 95% CI 2.06–6.73, Cox P = 1.38e−05) in univariate analysis. In multivariate analysis, the association of hypoalbuminemia with PFS was independent of serum LDH, IFN-γ signature expression, TMB, age, ECOG PS, treatment line, treatment type (combination or monotherapy), brain and liver metastasis (HR = 2.76, 95% CI 1.24–6.13, Cox P = 0.0131). Our validation cohort confirmed the prognostic power of hypoalbuminemia for OS (HR = 1.98, 95% CI 1.16–3.38; Cox P = 0.0127) and was complementary to serum LDH in analyses for both OS (LDH-adjusted HR = 2.12, 95% CI 1.2–3.72, Cox P = 0.00925) and PFS (LDH-adjusted HR = 1.91, 95% CI 1.08–3.38, Cox P = 0.0261). In conclusion, pretreatment hypoalbuminemia was a powerful predictor of outcome in ICI in melanoma and showed remarkable complementarity to previously established biomarkers, including high LDH.
Sustained attention operates via dissociable neural mechanisms across different eccentric locations
Authors: Phangwiwat Tanagrit , Phunchongharn Phond , Wongsawat Yodchanan , Chatnuntawech Itthi , Wang Sisi , Chunharas Chaipat , Sprague Thomas C. , Woodman Geoffrey F. , Itthipuripat Sirawaj 
Published: May 2024

AbstractIn primates, foveal and peripheral vision have distinct neural architectures and functions. However, it has been debated if selective attention operates via the same or different neural mechanisms across eccentricities. We tested these alternative accounts by examining the effects of selective attention on the steady-state visually evoked potential (SSVEP) and the fronto-parietal signal measured via EEG from human subjects performing a sustained visuospatial attention task. With a negligible level of eye movements, both SSVEP and SND exhibited the heterogeneous patterns of attentional modulations across eccentricities. Specifically, the attentional modulations of these signals peaked at the parafoveal locations and such modulations wore off as visual stimuli appeared closer to the fovea or further away towards the periphery. However, with a relatively higher level of eye movements, the heterogeneous patterns of attentional modulations of these neural signals were less robust. These data demonstrate that the top-down influence of covert visuospatial attention on early sensory processing in human cortex depends on eccentricity and the level of saccadic responses. Taken together, the results suggest that sustained visuospatial attention operates differently across different eccentric locations, providing new understanding of how attention augments sensory representations regardless of where the attended stimulus appears.
Autophagy favors survival of corpora lutea during the long-lasting pregnancy of the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha)
Authors: Caram Daira A. , Inserra Pablo I. F. , Vitullo Alfredo D. , Leopardo Noelia P. 
Published: May 2024

AbstractThe corpus luteum (CL) is a transient endocrine gland that plays a crucial role in establishing and maintaining pregnancy. Although autophagy and apoptosis have been suggested as cooperative mechanisms, their interaction within the CL of pregnant mammals has not been thoroughly investigated. To understand the collaborative function of autophagy and apoptosis in the CL, we analyzed both mechanisms during pregnancy in the South American plains vizcacha, Lagostomus maximus. This rodent undergoes a decline in progesterone levels during mid-gestation, a reactivation of the hypothalamus-hypophysis-gonadal axis, and the incorporation of new functional secondary CL. Our analysis of autophagy markers BECLIN 1 (BECN1), SEQUESTOSOME1 (SQSTM1), Microtubule-associated protein light chain 3 (LC3B), and lysosomal-associated membrane protein 1 (LAMP1) and anti- and pro-apoptotic markers BCL2 and ACTIVE CASPASE 3 (A-C3) revealed interactive behaviors between both processes. Healthy primary and secondary CL exhibited positive expression of BECN1, SQSTM1, LC3B, and LAMP1, while regressed CL displayed enhanced expression of these autophagy markers along with nuclear A-C3. Transmission electron microscopy revealed a significant formation of autophagic vesicles in regressed CL during full-term pregnancy, whereas healthy CL exhibited a low number of autophagy vesicles. The co-localization between LC3B and SQSTM1 and LC3B with LAMP1 was observed in both healthy and regressed CL during pregnancy, while co-localization of BECN1 and BCL2 was only detected in healthy CL. LC3B and ACTIVE CASPASE 3 co-localization were detected in a subset of luteal cells within the regressing CL. We propose that autophagy could act as a survival mechanism in the CL, allowing the pregnancy to progress until full-term, while also serving as a mechanism to eliminate remnants of regressed CL, thereby providing the necessary space for subsequent follicular maturation.
One-pot synthesis of quinazolinone heterocyclic compounds using functionalized SBA-15 with natural material ellagic acid as a novel nanocatalyst
Authors: Mohassel Yazdi Nazanin , Naimi-Jamal Mohammad Reza 
Published: May 2024

AbstractThe nanoporous compound SBA-15 was functionalized using (3-aminopropyl)trimethoxysilane (APTES). Then the obtained product was modified with ellagic acid (ELA), a bioactive polyphenolic compound. The structure of the prepared nanoporous composition SBA-15@ELA was extensively characterized and confirmed by various techniques, such as Fourier-transform infrared (FT-IR) spectroscopy, Energy dispersive X-ray (EDX) elemental analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM) and N2 adsorption–desorption isotherms (BET). The novel, recoverable, heterogenous SBA-15@ELA nanoporous compound was used to investigate its catalytic effect in the synthesis of 4-oxo-quinazoline derivatives (19 examples) with high yields (78–96%), as an important class of nitrogen-containing heterocyclic compounds. The use of an inexpensive mesoporous catalyst with a high surface area, along with easy recovery by simple filtration are among the advantages of this catalysis research work. The catalyst has been used in at least 6 consecutive runs without a significant loss of its activity.
T cell activation and deficits in T regulatory cells are associated with major depressive disorder and severity of depression
Authors: Rachayon Muanpetch , Jirakran Ketsupar , Sodsai Pimpayao , Sughondhabirom Atapol , Maes Michael 
Published: May 2024

AbstractMajor depressive disorder (MDD) is associated with T cell activation, but no studies have examined the combined effects of T cell activation and deficits in T regulatory (Treg) cells on the severity of acute phase MDD. Using flow cytometry, we determined the percentage and median fluorescence intensity of CD69, CD71, CD40L, and HLADR-bearing CD3+, CD4+, and CD8+ cells, and cannabinoid type 1 receptor (CB1), CD152 and GARP (glycoprotein A repetitions predominant)-bearing CD25+ FoxP3 T regulatory (Treg) cells in 30 MDD patients and 20 healthy controls in unstimulated and stimulated (anti-CD3/CD28) conditions. Based on cytokine levels, we assessed M1 macrophage, T helper (Th)-1 cell, immune-inflammatory response system (IRS), T cell growth, and neurotoxicity immune profiles. We found that the immune profiles (including IRS and neurotoxicity) were significantly predicted by decreased numbers of CD152 or GARP-bearing CD25+ FoxP3 cells or CD152 and GARP expression in combination with increases in activated T cells (especially CD8+ CD40L+ percentage and expression). MDD patients showed significantly increased numbers of CD3+ CD71+, CD3+ CD40L+, CD4+ CD71+, CD4+ CD40L+, CD4+ HLADR+, and CD8+ HLADR+ T cells, increased CD3+ CD71+, CD4+ CD71+ and CD4+ HLADR+ expression, and lowered CD25+ FoxP3 expression and CD25+ FoxP+ CB1+ numbers as compared with controls. The Hamilton Depression Rating Scale score was strongly predicted (between 30 and 40% of its variance) by a lower number of CB1 or GARP-bearing Treg cells and one or more activated T cell subtypes (especially CD8+ CD40L+). In conclusion, increased T helper and cytotoxic cell activation along with decreased Treg homeostatic defenses are important parts of MDD that lead to enhanced immune responses and, as a result, neuroimmunotoxicity.
Investigation of N$$_3$$C$$_5$$ and B$$_3$$C$$_5$$ bilayers as anode materials for Li-ion batteries by first-principles calculations
Authors: Kasprzak Grzegorz T. , Jarosik Marcin W. , Durajski Artur P. 
Published: May 2024

AbstractThe best choice today for a realistic method of increasing the energy density of a metal-ion battery is to find novel, effective electrode materials. In this paper, we present a theoretical investigation of the properties of hitherto unreported two-dimensional B$$_3$$

3

C$$_5$$

5

and N$$_3$$

3

C$$_5$$

5

bilayer systems as potential anode materials for lithium-ion batteries. The simulation results show that N$$_3$$

3

C$$_5$$

5

bilayer is not suitable for anode material due to its thermal instability. On the other hand B$$_3$$

3

C$$_5$$

5

is stable, has good electrical conductivity, and is intrinsically metallic before and after lithium intercalation. The low diffusion barrier (0.27 eV) of Li atoms shows a good charge and discharge rate for B$$_3$$

3

C$$_5$$

5

bilayer. Moreover, the high theoretical specific capacity (579.57 mAh/g) connected with moderate volume expansion effect during charge/discharge processes indicates that B$$_3$$

3

C$$_5$$

5

is a promising anode material for Li-ion batteries.