bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
Authors: Krismer Laura , Schöppe Helge , Rauch Stefanie , Bante David , Sprenger Bernhard , Naschberger Andreas , Costacurta Francesco , Fürst Anna , Sauerwein Anna , Rupp Bernhard , Kaserer Teresa , von Laer Dorothee , Heilmann Emmanuel 
Published: June 2024

AbstractThe Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an epidemic, zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has the potential to mutate or recombine with other coronaviruses, thus acquiring the ability to efficiently spread among humans and become pandemic. Its high mortality rate of up to 35% and the absence of effective targeted therapies call for the development of antiviral drugs for this pathogen. Since the beginning of the SARS-CoV-2 pandemic, extensive research has focused on identifying protease inhibitors for the treatment of SARS-CoV-2. Our intention was therefore to assess whether these protease inhibitors are viable options for combating MERS-CoV. To that end, we used previously established protease assays to quantify inhibition of SARS-CoV-2, MERS-CoV and other main proteases. Nirmatrelvir inhibited several of these proteases, whereas ensitrelvir was less broadly active. To simulate nirmatrelvir’s clinical use against MERS-CoV and subsequent resistance development, we applied a safe, surrogate virus-based system. Using the surrogate virus, we previously selected hallmark mutations of SARS-CoV-2-Mpro, such as T21I, M49L, S144A, E166A/K/V and L167F. In the current study, we selected a pool of MERS-CoV-Mpro mutants, characterized the resistance and modelled the steric effect of catalytic site mutants S142G, S142R, S147Y and A171S.
Experimental verification of nonreciprocal electromagnetic metasurface in a finite‐size array
Authors: Takahagi Kazuhiro , Tennant Alan 
Published: June 2024

AbstractThis paper presents experimental verification results for a finite‐sized array of a simple non‐reciprocal metasurface elements. The metasurface elements consists of ferrite loaded metal patches. Experimental results demonstrate nonreciprocity, achieving isolation exceeding 20 dB at 6.4 GHz in a 2×2 array. Additionally, these findings are compared with simulation results for a 4×4 array to validate its practicality in a finite array setting.
Future‐proofing city power grids: FID‐based efficient interconnection strategies for major load‐centred environments
Authors: Guo Peiqian , Tian Zhongbei , Yuan Zhichang , Qu Lu , Zhang Xiao‐Yu , Zhang Xiao‐Ping 
Published: June 2024

AbstractThe flexible interconnection device (FID) offers significant advantages for interconnecting different distribution networks flexibly. This paper focuses on the significant advantages offered by the FID for interconnecting different distribution networks flexibly. It specifically delves into FID‐based multi‐voltage and multi‐substation distribution networks, proposing a preferable scheme applicable to major load‐centred cities. Beginning with an analysis of constructed FID‐based flexible interconnected distribution network projects, key configurations and features are summarized. Subsequently, typical configurations, electrical parameters, facilities, relevant power functionalities, and application scenarios of multi‐voltage multi‐substation distribution networks are outlined. Building upon this foundation, a suitable interconnection scheme tailored for current urban use is explored to meet the specific needs of load‐centred cities, while incorporating recent advancements in high‐power‐density IGCT technology. An EMT model of a 10 kV/10 MW IGCT‐based four‐substation distribution network is developed in PSCAD/EMTDC. Through thorough analysis under different conditions, the operational performance and benefits are evaluated, providing insights into the efficiency and resilience of the proposed FID‐based interconnection. Lastly, challenges and prospects are discussed from various perspectives to advance the development of FID‐based flexible interconnection solutions. This study aims to contribute to the advancement and implementation of robust interconnection solutions to meet the evolving needs of major load‐centred cities.
Trans–Pars Interarticularis Approach for Lumbar Interbody Fusion: An Efficient, Straightforward, and Minimally Invasive Surgery for Lumbar Spondylolisthesis and Stenosis
Authors: Liu Zhao-Quan , Hsieh Cheng-Ta , Chang Chih-Ju 
Published: June 2024

Abstract
Background Lumbar interbody fusion is a commonly applied surgical treatment for spondylolisthesis. For this procedure, various minimally invasive (MIS) approaches have been developed, including posterior lumbar interbody fusion, transforaminal lumbar interbody fusion (TLIF), oblique lumbar interbody fusion, and anterior lumbar interbody fusion. In this study, we characterized the features of an MIS trans–pars interarticularis lumbar interbody fusion (TPLIF) and compared its surgical outcomes with those of MIS-TLIF.
Methods This study included 89 and 44 patients who had undergone MIS-TPLIF and MIS-TLIF, respectively, between September 2016 and December 2022. The following clinical outcomes were analyzed: operative time, blood loss, and hospitalization duration.
Results The average operative time, blood loss, and hospitalization duration for the MIS-TPLIF and MIS-TLIF groups were, respectively, 98.28 and 191.15 minutes, 41.97 and 101.85 mL, and 5.8 and 6.9 days.
Conclusion The MIS-TPLIF approach for lumbar spondylolisthesis or other degenerative diseases involves the use of the commonly available and cost-effective instrument Taylor retractor, thus enabling posterior lumbar interbody fusion to be performed with minimal invasion. This approach also confers the benefits of a short learning curve and an intuitive approach. Our results suggest that although MIS-TPLIF is noninferior to MIS-TLIF, it is easier to learn and perform than MIS-TLIF.
Exploring Ethical Dimensions in Neuropalliative Care
Authors: Gula Annie L. , Walter Jennifer K. , Morrison Wynne , Kirschen Matthew P. 
Published: June 2024

AbstractNeurologic illnesses can be challenging to diagnose, involve changes in consciousness, and are often complicated by prognostic uncertainty. These disorders can affect how individuals interact with their environment, and as a result, many ethical concerns may arise related to their medical care. Key ethical issues in neuropalliative care include shared decision-making, evolving autonomy and capacity, best interest and harm principles, beneficence and nonmaleficence, futile and inappropriate care, justice and equity, and ableism. The four core principles of medical ethics, beneficence, nonmaleficence, justice, and autonomy, are foundational in considering approaches to these ethical challenges. Shared decision-making is rooted in the principle of autonomy. Evolving autonomy and capacity evoke autonomy, beneficence, and nonmaleficence. The best interest and harm principles are rooted in beneficence and nonmaleficence. Questions of futility and inappropriate care are founded in the principles of nonmaleficence, autonomy, and justice. Ableism invokes questions of nonmaleficence, autonomy, and justice. Practitioners of neurology will encounter ethical challenges in their practice. Framing decisions around the core ethical principles of beneficence, nonmaleficence, autonomy, and justice will help clinicians navigate challenging situations while acknowledging and respecting each patient's individual story.
Understanding the Misconceptions about Traumatic Brain Injury among Indian Young Adults
Authors: Chauhan Shivalika , Afsar Mohammed 
Published: June 2024

Abstract
Background Traumatic brain injuries (TBIs) pose significant challenges globally. The implementation of TBI prevention programs is highly reliant on the prevalent misconceptions. There is a paucity of research exploring the misconceptions regarding TBIs among young adults in India. Therefore, the present study explores the prevalence and nature of misconceptions regarding TBIs among young adults.
Materials and Methods This prospective survey study, with 150 participants aged 18 to 25 years, utilized the Common Misconceptions about Traumatic Brain Injury questionnaire comprising 40 items across 7 domains. The data was analyzed using Jamovi (2.3.28 solid).
Results The results revealed that the participants have high rates of misconception regarding brain injury sequelae, brain damage, and seatbelt prevention and low rates regarding the posttraumatic amnesia. Overall, females exhibited a higher rate of misconceptions compared with males. Higher years of education were associated with lesser misconceptions. Prior exposure to TBI had no significant impact on overall awareness of TBI.
Conclusion This study highlights important misconceptions about TBIs among young adults. Education and gender might play a vital role in these misconceptions. These findings might inform the development of preventive modules for TBIs and to enhance their effectiveness.
A Rare Complex Case Report: Bilateral Congenital Internal Carotid Artery Hypoplasia Associated with Ruptured Left True Posterior Communicating Artery Aneurysm
Authors: Soni Tushar V. , Patel Shreyansh , Shah Varshesh , Deo Manas Ranjan , Kotadiya Kuldeep 
Published: June 2024

AbstractCongenital internal carotid artery hypoplasia is a rare condition characterized by underdevelopment or reduced caliber of the internal carotid artery during embryonic development. This anomaly presents significant challenges in management, particularly in neurosurgical interventions for cerebrovascular events. We present a case report of a 67-year-old male who presented with subarachnoid hemorrhage and intraparenchymal hemorrhage extending as intraventricular hemorrhage due to a ruptured left true posterior communicating artery aneurysm, associated with intraoperative findings of left internal carotid artery aneurysm, accompanied by incidental findings of bilateral congenital hypoplasia of the internal carotid artery on computed tomography angiography. Surgical intervention involved a left frontotemporal craniotomy, during which both aneurysms were successfully clipped. This case underscores the critical importance of meticulous preoperative evaluation, utilizing advanced neuroimaging modalities to identify such anomalies, particularly in patients with acute cerebrovascular events. Furthermore, it emphasizes the necessity for meticulous surgical planning and intraoperative vigilance to effectively manage associated vascular pathologies.
Comparative Evaluation of Clinical Outcome Including Neurosensory Deficit and Pain Score Variables Using Rigid Internal Fixation with Three-Dimensional Miniplate Internal Fixation in Simultaneous Angle and Contralateral Body/Parasymphysis Fractures of the Mandible: A Prospective, Randomized Controlled Study
Authors: Kumar Satish , Chandran Ajay , Hassan Syed Sirajul , Rocchetta Davide , Alshammari Abdulsalam S. , Almutairi Faris Jaser , Jandrajupalli Suresh Babu , Chandolu Swarnalatha , Nayyar Abhishek Singh 
Published: June 2024

Abstract
Purpose There have been numerous advancements in the strategies used for treating mandibular fractures in the present times, while open reduction and internal fixation is still accepted as the most preferred treatment option for such fractures despite numerous drawbacks. The aim of the present prospective, randomized controlled study was to evaluate the clinical outcome including neurosensory deficit and pain score variables in mandibular fractures that were treated using rigid internal fixation with three-dimensional (3D) miniplate internal fixation.
Materials and Methods For the present study, a total of 20 patients of either sex in an age range of 18 to 55 years with simultaneous angle and contralateral body/parasymphysis fractures of the mandible were included, while the clinical outcome was compared in relation to the two groups wherein different treatment options were used including using rigid internal fixation in one as against 3D miniplate internal fixation in the other.
Results Pairwise comparison of pain scores in Group I and Group II patients by the Mann–Whitney U-test at different time zones revealed the results to be statistically significant for all pairs except when the findings were compared between 1 month and 3 months after the procedure in Group II patients. Also, significant recovery was observed in both Group I and II patients during healing when assessed preoperatively to 1 month and then 3 months after the procedure with the results being statistically highly significant in case of the variations observed in relation to the neurosensory deficit observed at different time zones for both Group I and II patients (p = 0.0001).
Conclusion Based on the results obtained, it can be concluded that 3D miniplate-led osteosynthesis was found comparable to the osteosynthesis accomplished using reconstruction plates during fixation of unfavorable body/parasymphysis fractures of mandible in study, providing optimal stability, while satisfactorily meeting the biomechanical requirements for occlusal loading, and an early return to normal function.
Intrasylvian Retraction Technique to Facilitate the Sylvian Fissure Dissection: A Clinical Study of 125 Cases
Authors: Sriamornrattanakul Kitiporn , Ariyaprakai Chanon 
Published: June 2024

AbstractAlthough many authors have recommended the retractorless technique to avoid retractor-induced brain injury, others usually use brain retractors with a meticulous technique to facilitate the surgery, especially for sylvian fissure dissection. The intrasylvian retraction technique was described for sylvian fissure opening, but no clinical evidence was found. We evaluate the efficacy and safety of this technique for the distal transsylvian approach. We reviewed the video records of clinical cases where the distal transsylvian approach was performed using the intrasylvian retraction technique for aneurysm treatment and middle cerebral artery (MCA) bypass between September 2018 and August 2022. Operative techniques are described. The efficacy and safety of the technique were assessed by full exposure of the sylvian fissure and new postoperative perisylvian hematoma, respectively. One hundred twenty-five cases were included and had an average age of 53.5 (range 16–85) years. Women comprised 73.6%. Aneurysm surgery, pure MCA revascularization, and aneurysm surgery with MCA revascularization were 106 (84.8%), 12 (9.6%), and 7 cases (5.6%), respectively. The most common aneurysm location was the internal carotid artery-posterior communicating artery junction in 37 cases (34.9%), followed by the anterior communicating artery in 27 (25.5%). Full exposure of the Sylvian fissure was achieved in all cases. No perisylvian hematoma was detected by immediate postoperative computed tomography in any patient. Using an appropriate technique for brain retractor application, sylvian fissure dissection was safely performed. The intrasylvian retraction technique effectively facilitated sylvian fissure dissection and provided wide exposure for the distal transsylvian approach.
Beyond the Marrow: Unveiling Uncommon Sites of ALL Relapse with 18F-FDG PET/CT
Authors: Kar Siven , Gupta Harshita , Shaikh Nusrat , Lele Vikram 
Published: June 2024

AbstractExtramedullary infiltration of acute lymphoblastic leukemia/lymphoma (ALL) to genital organs is extremely rare. Here, we present a case report of an asymptomatic 49-year-old female, known case of precursor B-cell ALL, who was incidentally detected with thickened and heterogeneously hyperechoic endometrium on sonography. Contrast magnetic resonance imaging detected large polypoidal enhancing lesions showing intense diffusion restriction occupying the endometrial cavity and similar lesions in the left adnexa, left ovary, and fallopian tube which were suspicious for leukemic infiltration because of the clinical history and atypical appearance of the lesions. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) was done which revealed intensely metabolically active lesion in the endometrial cavity, left adnexa, omental nodules, retroperitoneal lymph node, pancreatic lesion, and few irregular nodules in the right lower lobe. Biopsy findings confirmed extramedullary relapse of ALL. Hence, 18F-FDG PET/CT can act as a good whole body survey to look for extramedullary sites of relapse.
Dynamic analysis of the relationship between exchange rates and oil prices: a comparison between oil exporting and oil importing countries
Authors: Chen Shiying , Chang Bisharat Hussain , Fu Hu , Xie ShiQi 
Published: June 2024

AbstractAddressing the interconnectedness of oil prices and foreign exchange rates poses a substantial challenge and raises significant questions within economic research. Existing studies reveal a fragmented understanding of the dynamics between these crucial variables, highlighting a need for deeper investigation. This study extends previous research by employing the time-varying parameter VAR extended joint connectedness model and using the baseline approach called the generalized connectedness approach. Our research findings indicate that exchange rates and crude oil prices exhibit pairwise and total connectedness, varying over time. Furthermore, this connectedness experiences substantial increases during severe crisis periods. We uncover that exchange rates and crude oil prices not only share a dynamic, pairwise, and total connectedness but these results are stronger for oil exporting countries. However, these methods yield inconsistent results for various countries. Moreover, there is compelling evidence that fluctuations in exchange rates and oil prices can cause bi-directional and time-dependent shocks.
Thermalization dynamics in photonic lattices of different geometries
Authors: Yang Guowen , Bongiovanni Domenico , Song Daohong , Morandotti Roberto , Chen Zhigang , Efremidis Nikolaos K. 
Published: June 2024

The statistical mechanical behavior of weakly nonlinear multimoded optical settings has been attracting increased interest over the last few years. The main purpose of this work is to numerically investigate the main factors that affect the thermalization process in photonic lattices. In particular, we find that lattices with identically selected properties (such as temperature, coupling coefficient, lattice size, and excitation conditions) can exhibit very different thermalization dynamics and, thus, thermalization distances. Our investigation is focused on two different two-dimensional lattices: the honeycomb lattice and the triangular lattice. Our numerical results show that, independently of the excitation conditions, the honeycomb lattice always thermalizes faster than the triangular lattice. We mainly explain this behavior by the quasilinear spectrum that promotes wave-mixing in the honeycomb lattice in comparison to the power-like spectrum of the triangular lattice. In addition, we investigate the combined effects of temperature as well as the sign and magnitude of the nonlinearity. Switching either the sign of the Kerr nonlinear coefficient or the sign of the temperature can lead to significant differences in the thermalization dynamics, a phenomenon that can be physically explained in terms of wave instabilities. Larger absolute values of the temperature |T| result in more uniform distributions for the power occupation numbers and faster thermalization speeds. Finally, as expected, increasing the magnitude of the nonlinearity results in accelerated thermalization. Our findings provide valuable insights into optical thermalization in discrete systems, where experimental realization may bring about new possibilities for light manipulation and applications.
A self-regulation blades wind energy harvester system for self-powered wireless monitoring sensors
Authors: Wang Qingcheng , Li Xinjun , Fan Zhengwu , Fan Duxing , Wan Deshuo 
Published: June 2024

Using wind energy in the natural environment provides a promising solution for wireless sensor power supply for ecological, meteorological, environmental, and infrastructure monitoring. However, the uncertainty and disorder of natural wind restrict the further development of wind energy harvester systems and self-powered wireless sensor technology. Hence, this paper proposes a self-regulation blade wind energy harvester system (SBWEHS) for self-powered wireless monitoring sensors in remote field areas with power shortages. The system is mainly composed of three parts: wind harvesting mechanism, generator module, and energy storage module. The device can control the blade overlap ratio according to the wind speed while generating electricity to maximize the power coefficient. The system can control the blade’s closure in bad weather to protect the device. Based on the computational fluid dynamics technology of Ansys Fluent software, this study evaluated the impact of wind speed and blade overlap ratio on the two-stage blades. Experiments revealed that when the overlap ratio of the blades is fixed at 0.2 and the wind speed is set at 16 m/s, the maximum average power will reach 0.79 W, which fulfills the power requirements of wireless sensors. These results illustrate that the SBWEHS can effectively supply power for wireless monitoring sensors, especially in remote natural environments.
Color image encryption algorithm based on variable parameter improved Sine chaotic mapping and DNA coding XOR scrambling*
Authors: Mou Dingkang , Xia Chuanrong , Dong Yumin 
Published: June 2024

Abstract
With the widespread application and dissemination of digital images in all aspects of life, the need for image information security and privacy protection is becoming increasingly urgent. Image encryption technology plays a crucial role in the field of information security and has garnered significant attention because it can effectively safeguard the privacy and integrity of image data. This study innovatively designed a color image encryption algorithm by combining the Sine chaotic mapping with the trigonometric function Cosine. It utilized the dichotomy idea for segmentation and introduced an improved Sine chaotic mapping (ISCM). By adjusting the parameter combination of ISCM, the complexity of the key space is effectively enhanced. The random chaotic sequence generated by the ISCM is used to control the DNA encoding and decoding process. At the same time, through star scrambling technology, the limitations of the single number of traditional DNA rules are overcome. Color images are confused and scrambled in multiple dimensions, enhancing the security and reliability of the encryption process. This provides a high level of protection for the transmission of image data, reducing the risks of data leakage and tampering. In the analysis of experimental data, the average value of the UACI test data perfectly matches the ideal value of 33.4635%, and the average value of the information entropy analysis data is 7.999 or above. This further verifies the superiority and reliability of this study.