bluuebunny/crossref_metadata_2025_split huggingface dataset:
CATEcor: An Open Science, Shaded-Truss, Externally-Occulted Coronagraph
Authors: DeForest Craig , Seaton Daniel B. , Caspi Amir , Beasley Matt , Davis Sarah J. , Erickson Nicholas F. , Kovac Sarah A. , Patel Ritesh , Tosolini Anna , West Matthew J. 
Published: June 2024

AbstractWe present the design of a portable coronagraph, CATEcor (where CATE stands for Continental-America Telescope Eclipse), that incorporates a novel “shaded-truss” style of external occultation and serves as a proof-of-concept for that family of coronagraphs. The shaded-truss design style has the potential for broad application in various scientific settings. We conceived CATEcor itself as a simple instrument to observe the corona during the darker skies available during a partial solar eclipse, or for students or interested amateurs to detect the corona under ideal noneclipsed conditions. CATEcor is therefore optimized for simplicity and accessibility to the public. It is implemented using an existing dioptric telescope and an adapter rig that mounts in front of the objective lens, restricting the telescope aperture and providing external occultation. The adapter rig, including occulter, is fabricated using fusion deposition modeling (FDM; colloquially “3D printing”), greatly reducing cost. The structure is designed to be integrated with moderate care and may be replicated in a university or amateur setting. While CATEcor is a simple demonstration unit, the design concept, process, and trades are useful for other more sophisticated coronagraphs in the same general family, which might operate under normal daytime skies outside the annular-eclipse conditions used for CATEcor.
Coarse-Grained Molecular Dynamics Simulations of Nanoscale Roughness Effects on Oil Film Delamination
Authors: Deng Shizhe , Kubo Atsushi , Todaka Yoshikazu , Shiihara Yoshinori , Mitsuhara Masatoshi , Umeno Yoshitaka 
Published: June 2024

AbstractIn boundary lubrication, the detachment of lubricant molecules from a solid surface is likely to occur due to the presence of high compressive normal stress combined with shear stress exerted on the solid–liquid interface. This phenomenon often results in a delamination behavior at the interface. We aim to investigate the nanoscale roughness effect on the oil film delamination from sliding iron surfaces with grain boundaries by coarse-grained molecular dynamics simulations. As a result, the oil film delamination was effectively suppressed in higher roughness. Two distinct mechanisms of delamination were found depending on surface roughness when the critical normal stress is exceeded. High roughness enhanced the ability to prevent complete slip but had negligible influence on partial slip.
Graphical Abstract
Neutrophil-to-lymphocyte ratio and red blood cell distribution width to platelet ratio and their relationships with inflammatory and antioxidant status in dogs with different stages of heart failure due to myxomatous mitral valve disease
Authors: Kocaturk Meriç , Saril Ahmet , Oz Abdullah Doğukan , Rubio Camila Peres , Ceron Jose Joaquin , Yilmaz Zeki 
Published: June 2024

AbstractWe aimed to evaluate the red blood cell distribution width-to-platelet ratio (RDW/PLT) with other complete blood cell count (CBC) indices and their correlations with serum proinflammatory cytokines, acute phase proteins (APPs), and antioxidant biomarkers in dogs at different stages of heart failure (HF). A total of 29 dogs were divided into four groups according to the ACVIM Consensus Statement: stage-A (healthy/controls, n = 8), stage-B2 (n = 6), stage-C (n = 10), and stage-D (n = 5). Seventeen CBC indices were calculated and correlated with the measurements of inflammatory, APPs, and antioxidant biomarkers, as well as selected echocardiographic variables in all dogs. At stage-C, CBC indices were evaluated 14 days after the treatment. Statistically significant changes were observed only for RDW/PLT and neutrophil-to-lymphocyte ratio (NLR) between groups. NLR increased, but RDW/PLT deceased in dogs with HF, compared to controls (P < 0.05). There were no statistically differences between pre- and post-treatment CBC indices. There were significantly positive and negative correlations between the CBC indices, serum parameters and selected echocardiographic variables in dogs with HF(P < 0.05). ROC analysis showed the best sensitivity (57% and 68%) and specificity (100% and 57%) for NLR > 5.8 and RDW/PLT ≤ 0.057 for predicting the severity of HF, respectively. Results showed that NLR and RDW/PLT may have potential for monitoring severity of the disease and the effect of treatment in dogs with HF. Imbalances between indices of circulating blood cells can contribute to immunoinflammatory and antioxidant responses in pathogenesis of canine HF, which may provide us alternative targets to develop new diagnostic and therapeutic strategies in veterinary medicine.
How undergraduate students learn: uncovering interrelationships between factors that support self-regulated learning and strategy use
Authors: Hey Rebecca , McDaniel Mark , Hodis Flaviu A. 
Published: June 2024

AbstractBeing an effective learner is an important pillar supporting success in higher education and beyond. This research aimed to uncover the extent to which undergraduate students use a set of commonly researched learning strategies, as well as to understand how learning strategy usage relates to key self-regulation factors proposed in influential models of self-regulated learning. Undergraduate students from New Zealand (N = 140) were recruited through course management systems, social media, and campus posters. Data were analysed using correlation and multiple regression. Results show that students reported using more learning strategies that are relatively effective than learning strategies that are somewhat less effective. In addition, effort regulation and student engagement were the most consistent predictors of both learning strategy use and self-reported academic achievement. Building on these findings, this research provides important new insights into the associations between learning strategy usage and pivotal factors that support effective self-regulated learning and academic achievement. As we highlight in the article, these insights have key implications for advancing theory and research on self-regulated learning.
Being in Two Places at the Same Time: a Future for Hybrid Learning Based on Student Preferences
Authors: Fabian Khristin , Smith Sally , Taylor-Smith Ella 
Published: June 2024

AbstractThe Covid-19 pandemic moved focus from face-to-face learning to hybrid in Higher Education; many educators did not have previous experience of this mode prior to this shift in learning locations. One form of hybrid learning is “synchronous hybrid learning” where both face-to-face and online students simultaneously attend learning activities. This study set out to explore students’ experiences of, and attitudes towards, synchronous hybrid learning, using a multi-method approach: a student survey (n = 66) and interviews with both students (n = 22) and lecturers (n = 8). Findings reveal technology challenges for both face-to-face and online learning but the majority of students preferred hybrid learning. Students acknowledged that hybrid formats provided fewer opportunities to collaborate and that they felt more engaged when face-to-face, but they could manage their time better with hybrid. Staff observed equity-related benefits, while acknowledging increased complexity of delivery. The study makes recommendations for a future that encompasses good quality, post-pandemic hybrid learning.
Analysis of the spatiotemporal trends and influencing factors of Hyphantria cunea in China
Authors: Zhou Hongwei , Gong Chaoqun , Li Xiaodong , Wang Yue , Yan Yunbo 
Published: June 2024

AbstractIn recent years, the situation of the Hyphantria cunea (Drury) (Lepidoptera: Erebidae), infestation in China has been serious and has a tendency to continue to spread. A comprehensive analysis was carried out to examine the spatial distribution trends and influencing factors of H. cunea. This analysis involved integrating administrative division and boundary data, distribution data of H. cunea, and environmental variables for 2021. GeoDetector and gravity analysis techniques were employed for data processing and interpretation. The results show that H. cunea exhibited high aggregation patterns in 2021 and 2022 concentrated mainly in eastern China. During these years, the focal point of the infestation was in Shandong Province with a spread towards the northeast. Conditions such as high vegetation density in eastern China provided favorable situations for growth and development of H. cunea. In China, the spatial distribution of the moth is primarily influenced by two critical factors: precipitation during the driest month and elevation. These play a pivotal role in determining the spread of the species. Based on these results, suggestions are provided for a multifaceted approach to prevention and control of H. cunea infestation.
In vitro and in vivo antimicrobial activity of the fumigant, ethyl formate, against bacteria and fungi of date fruits in postharvest phase
Authors: Abo-El-Saad Mahmoud M. , Badawy Mohamed E. I. , Shawir Mohamed S. , Hegazi Yasser H. , Mohammed Youssef M. M. 
Published: June 2024

AbstractThe search is on for safer alternatives to fumigants like methyl bromide and phosphine, which harm the ozone layer and pose other risks. Ethyl formate is a promising candidate due to its potential antimicrobial and insecticidal action in stored products like date fruits. The susceptibility of date fruits to microbial spoilage is significantly influenced by factors such as moisture content, storage practices, and environmental conditions. In the present study, the in vitro antimicrobial effect of ethyl formate against three microbial species, namely Aspergillus niger F4, Mucor circinelloides YMM22, and Pseudomonas aeruginosa B1 was tested under laboratory conditions. In addition, two common date fruit varieties, semi-dry El-Wady I and the dry Frehi, were fumigated with ethyl formate alone in a laboratory-scale prototype and with a mixture of ethyl formate and CO2 at a semi-industrial scale prototype. Both varieties had an initial moisture content of around 13.40 and 12.48% for El-Wady I and Frehi, respectively. The fumigation was conducted using the optimal concentration of 70 mg/L air for 24 h incubation period. Fumigation with ethyl formate alone or in combination with CO2 significantly reduced the number of viable bacteria and fungi (CFU/g), but the potential for a combined effect with CO2 was not investigated. The percentages of reduction in the fungal count were 78.18 and 90.76% for Frehi and El-Wady I varieties, respectively in a semi-industrial scale prototype. Moreover, the percentages of reduction in the bacterial count were 53.31 and 65.20%, respectively for Frehi and El-Wady I varieties. Ethyl formate showed promise as a natural alternative to control microbial contamination of stored date fruits. Further research suggests that increasing fumigation duration or concentration could provide comprehensive control of microbial pathogens at all stages of development.
Robots down-under: the current climate of robotic-assisted surgery education in Australia
Authors: Sakalkale Aditya , Satheakeerthy Shriranshini , Yeung Justin M. C. , Reid Fiona 
Published: June 2024

AbstractAustralia has seen a significant rise in the use of Robotic-Assisted Surgery (RAS), with general surgery being the fastest-growing field in this technology. The proportion of general surgical RAS has grown from 1% to 17% of all RAS between 2008 and 2023 in Australasia. As of May 2023, there were 162 robotic platforms in Australasia, with 26 of them in the public sector. As the cost of establishing RAS decreases over time, public hospital robotics systems are expected to become more accessible. Despite the increasing demand, many specialties, including general surgery, do not have an agreed RAS curriculum for trainees. It is imperative for Australia to develop its own curriculum akin to our overseas colleagues to match this growth.
Determining anthropogenic pressure on the Southern Black Sea blue flag beaches
Authors: Guneroglu Nilgun , Guneroglu Abdulaziz , Dihkan Mustafa , Sari Derya , Onur Makbulenur , Demirsoy Emine Hilal , Hamzaoglu Canan , Yilanci Gulsena 
Published: June 2024

AbstractCoasts are settlement areas that attract human for many years. Türkiye, geographically located on Mediterranean Basin and Asian Continent passage with unique climate regime, has a great coastal zone. The mid-latitude geographic setting makes possible to experience coastal recreation and tourism activities for almost all year along. Among all activities sun, sea and sand tourism can be placed on the first stage. Recent changes in local climate of the Black Sea such as rising mean atmospheric temperatures and increasing number of sunny days have triggered touristic beach activities in the region. In the literature, there are different techniques for grading and classifying coastal beaches. In this study, as an integral part of coastal landscape formation Land Use/Land Cover (LULC) structure is linked to landscape value and regarded as cover changes that determines landscape pattern of the area under investigation. The research rationale of this study is based on an assumption of Southern Black Sea coastal blue flag beaches are under severe anthropogenic pressure. For this purpose, 15 blue flag beaches which are located on the Black Sea coast of Türkiye were selected based on their morphological dimensions. To determine landscape changes and potential human induced effects on selected beaches for the last 35–40 years period, georeferenced, atmospherically corrected Landsat 5 TM and Landsat 8 OLI-TIRS satellite images were used. Furthermore, carrying capacities for all researched beaches were calculated and documented in order to find the actual human usage frequencies during the high season. According to results of the study, it is clearly observed that all beach areas are under anthropogenic pressure. The most important evidence of this situation is the proportional increases in the IS (Impervious Surface) cover class in the classified images between 1984 and 1985 and 2021 in all 15 beaches. Moreover, these increases have reached up to 5–6 times for some beaches. As inferred, from the field surveys, beach carrying capacities were also exceeded for the most of the beaches under investigation. This means the blue flag beaches of Southern Black Sea are not only affected by construction and urbanization but also under intense pressure of overuse during the high seasons. It is revealed that these areas should be carefully managed with state-of-the-art techniques that prioritize adaptive planning that takes into account all stakeholders participation. Moreover, the activities, authorization and attitudes of municipalities regarding the coastal zones must be limited and inspected by a higher organization.
Efficacy and safety of once-weekly tirzepatide for weight management compared to placebo: An updated systematic review and meta-analysis including the latest SURMOUNT-2 trial
Authors: Qin Wenhui , Yang Jun , Ni Ying , Deng Chao , Ruan Qinjuan , Ruan Jun , Zhou Peng , Duan Kai 
Published: June 2024

Abstract
Aim
Tirzepatide, a newly developed dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, has received approval for treating type 2 diabetes (T2D) and is currently being studied for its potential in long-term weight control. We aim to explore the safety and efficacy of once-weekly subcutaneous tirzepatide for weight loss in T2D or obese patients.

Methods
A comprehensive search was performed on various databases including PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov from inception up to April 29, 2024, to identify randomized controlled trials (RCTs) that assessed the efficacy of once-weekly tirzepatide compared to a placebo in adults with or without T2D. The mean difference (MD) and risk ratio (RR) were calculated for continuous and dichotomous outcomes, respectively. The risk of bias was evaluated using the RoB-2 tool (Cochrane), while the statistical analysis was conducted utilizing RevMan 5.4.1 software.

Results
Seven RCTs comprising 4795 individuals ranging from 12 to 72 weeks were identified. Compared to the placebo group, tirzepatide at doses of 5, 10, and 15 mg demonstrated significant dose-dependent weight loss. The mean difference (MD) in the percentage change in body weight (BW) was −8.07% (95% CI −11.01, −5.13; p < 0.00001), −10.79% (95% CI −13.86, −7.71; p < 0.00001), and −11.83% (95% CI −14.52, −9.14; p < 0.00001), respectively. Additionally, the MD in the absolute change in BW was −7.5 kg (95% CI −10.9, −4.1; p < 0.0001), −11.0 kg (95% CI −16.9, −5.2; p = 0.0002), and −11.5 kg (95% CI −16.2, −6.7; p < 0.00001), for the 5, 10, and 15 mg doses, respectively. All three doses of tirzepatide also significantly reduced body mass index and waist circumference. Furthermore, it led to a greater percentage of patients experiencing weight loss exceeding 5, 10, 15, 20, and 25%. Moreover, tirzepatide showed great success in reducing blood pressure, blood sugar levels, and lipid profiles. In terms of safety, gastrointestinal side effects were the most frequently reported adverse events in all three doses of tirzepatide groups, which were generally mild-to-moderate and transient.

Conclusion
Tirzepatide treatment could lead to remarkable and sustained weight loss that is well-tolerated and safe, representing a novel and valuable therapeutic strategy for long-term weight management.
The role of the adrenalectomy in the management of pheochromocytoma: the experience of a Portuguese referral center
Authors: Carvalho Inês Costa , Machado Miguel V. B. , Morais João P. , Carvalho Filipa , Barbosa Elisabete , Barbosa José 
Published: June 2024

Abstract
Purpose
Pheochromocytoma is a rare neuroendocrine tumor. Despite the low incidence, these tumors are of indisputable importance. This study aimed to analyze the management of pheochromocytoma in a referral center, with an emphasis on the minimally invasive adrenalectomy, which is the preferred therapeutic approach.

Methods
A retrospective analysis was performed on a cohort of patients diagnosed with pheochromocytoma who underwent adrenalectomy between January 2013 and December 2022. Clinical data including demographics, timelines, symptomatology, comorbidities, biochemical markers, genetic testing, surgical details, and follow-up outcomes, were collected and analyzed.

Results
The cohort included 44 patients, predominantly women (52.27%), with a median age of 53.39 years (range 13–83). Most of patients exhibited paroxysmal symptoms suggesting catecholamine excess. Documented hypertension was the most frequent (86.36%), along with glucose anomalies (40.01%) and anxiety disorder (31.82%). Genetic testing was performed in 36 (81.81%) patients and 14 (38.88%) revealed a positive result, predominantly RET pathogenic variant. Laparoscopic surgery was performed in 34 (79.07%) patients, showing significantly shorter operative time (2.5 h vs. 4.25 h, t-test p < 0,001) and fewer complications (23.53% vs 77.78%, p = 0.008). Postoperative complications occurred in 36.36% of the patients, mostly mild (grade I, 56.25%), with no mortality. SDHB pathogenic variant correlated with both recurrent and metastatic disease (p = 0.006). One-year follow-up reported 9.09% recurrence and 6.82% metastasis.

Conclusions
Adrenalectomy demonstrated a high safety and effectiveness. This study exhibited a higher rate of genetic testing referral than other studies. Despite past advances, there is still a need for further studies to establish protocols and evaluate new techniques.
Valorization of Crustacean Shells: Preparation, Characterization, and Chemical Modification of Nano-Chitin Biopolymer Membrane for Application in Water Purification
Authors: Lakshmi D. Shanthana , Ravindran Lakshmipriya , Mary P. J. Maida , Rathika G. , Sreekala M. S. , Munisamy Shanmugam 
Published: June 2024

AbstractShrimp and crab shells are the most promising and viable source of raw material for the manufacturing of chitin and its derivatives. In-depth understanding of the biological properties of chitin and scientific advancements in the field of nanotechnology have enabled the development of high-performance chitin nanomaterials. Nanoscale chitin is of great economic value as a functional and reinforcement material for a wide range of applications including water purification. The use of nano-chitin to produce (bio) nanocomposites offers a good opportunity to prepare membrane materials with enhanced functional and structural properties. Chitosan-based membranes are found to be effective in water purification for the removal of pollutants like organic wastes, heavy metals, antibiotics, pathogenic microbes and acid waste. These membranes are environmentally friendly and can be used as a method to reduce humic acid waste from the aquatic environment. This review focuses on the preparation, characterization and chemical modification of nano chitin membrane and its application for water purification and water treatment.
Anti-tumor effect of dandelion flavone on multiple myeloma cells and its mechanism
Authors: Gui Hua , Fan Xiaohong 
Published: June 2024

Abstract
Background
Multiple myeloma (MM) is a prevalent hematologic malignancy characterized by the uncontrolled proliferation of monoclonal plasma cells in the bone marrow and excessive monoclonal immunoglobulin production, leading to organ damage. Despite therapeutic advancements, recurrence and drug resistance remain significant challenges.

Objective
This study investigates the effects of dandelion flavone (DF) on MM cell proliferation, migration, and invasion, aiming to elucidate the mechanisms involved in MM metastasis and to explore the potential of traditional Chinese medicine in MM therapy.

Methods
DF's impact on myeloma cell viability was evaluated using the CCK-8 and colony formation assays. Cell mobility and invasiveness were assessed through wound healing and transwell assays, respectively. RT-PCR was employed to quantify mRNA levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Apoptotic rates and molecular markers were analyzed via flow cytometry and RT-PCR. The PI3K/AKT signaling pathway was studied using Western blot and ELISA, with IGF-1 and the PI3K inhibitor LY294002 used to validate the findings.

Results
DF demonstrated dose-dependent inhibitory effects on MM cell proliferation, migration, and invasion. It reduced mRNA levels of MMP-2 and MMP-9 while increasing those of TIMP-1 and TIMP-2. Furthermore, DF enhanced the expression of pro-apoptotic proteins and inhibited M2 macrophage polarization by targeting key molecules and enzymes. The anti-myeloma activity of DF was mediated through the inhibition of the PI3K/AKT pathway, as evidenced by diminished phosphorylation and differential effects in the presence of IGF-1 and LY294002.

Conclusion
By modulating the PI3K/AKT pathway, DF effectively inhibits MM cell proliferation, migration, and invasion, and induces apoptosis, establishing a novel therapeutic strategy for MM based on traditional Chinese medicine.