bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and characterization of novel magnesium oxide nanoparticle-impregnated chitosan-based guided tissue regeneration membrane – An in vitro study
Authors: Harris Johnisha , Gurumoorthy Kaarthikeyan 
Published: February 2025

Abstract:

Introduction:
Although a lot of commercially available guided tissue regeneration (GTR) membranes are used, none of them could actually ensure complete bone regeneration so far and they also have certain limitations. This study aims to explore further and develop a membrane that might overcome these limitations and aid in bone regeneration for the treatment of bony defects.

Materials and Methods:
Magnesium oxide nanoparticles (MgONPs) were prepared from magnesium nitrate prepared by calcination at different temperatures and dried using filter paper under specific temperature. Later, 0.3 ml of 0.2 M 1% acetic acid was added to water and placed in the stirrer for at least 1 h. Chitosan (CS) (2%) of two different concentrations containing 0.588 g and 0.576 g of CS, respectively, was prepared and added to the previous mixture. To these concentrations, the prepared MgONPs were added and stirred using a magnetic stirrer for 1 h. Later, it was cast in the mold and dried. The prepared membrane was immersed in 1 M sodium hydroxide to neutralize acetic acid. After preparation, they were subjected to scanning electron microscope (SEM) analysis, energy-dispersive X-ray (EDAX), Fourier transform infrared spectroscopy (FTIR), and contact angle test.

Results:
In SEM analysis, spherical in size, uniformly dense, and porous agglomeration was noticed. EDAX and FTIR revealed the formation of MgONPs (magnesium oxide) in the membrane. The average contact angles of the CS with MgONPs and control membranes were 85.48° and 80.80°, respectively. Degradation analysis showed that test membrane showed a slower degradation rate than control collagen membrane at the end of the 28th day.

Conclusion:
On comparing membranes with pure CS, membranes with nanoparticles, and control collagen membranes, the membrane incorporated with nanoparticles showed more favorable positive outcomes.
Does Revisiting Multidimensional Energy Poverty Measurement Index Address Universal Energy Access?
Authors: Bajpayee Priyandu M , Mohanty Pratap C. 
Published: February 2025

The study advocates for an update to the Multidimensional Energy Poverty Index, originally introduced by Nussbaumer et al. in 2012. By integrating developments from the past decade, the revised index enhances the existing indicators and provides a comprehensive framework for measuring household-level energy access. This update enables researchers and policymakers to evaluate energy access, formulate effective policies, mitigate energy poverty, and advance sustainable energy initiatives for all more precisely.
Prepare and Evaluate Bio Enzyme Shampoo from Hibiscus Rosa Sinensis and Sapindus Trifoliatus.
Authors: Y Hemalatha , S Siva Kumar , N Mahathi , N Purna Pranay , N Satheesh , K Sukanya 
Published: February 2025

The bio-enzymes are biological catalysts and are made up of proteins they also contain metabolites, lipids and carbohydrates. In our study the bioenzyme as prepared by using jaggery (30g), hibiscus petals (90g) and water (300 ml) by fermentation process for 1.5 months. The produced bioenzyme gave economical yield. The bioenzyme shampoo was prepared by using produced bioenzyme and sapindustrifoliantus. Hibiscus Rosa sinensis and sapindustrifoliantus both have the good hair conditioning properties and also they have antioxidants and metabolites. The formulated bioenzyme shampoo was evaluated for the quality and stability by physico chemical analysis and foam stability test along with wetting time estimation. All the ingredients used to formulate the shampoo was safer than synthetic commercial shampoos, and the physicochemical evaluation showed ideal results, but further research is required to improve its quality and specially on the conditioning performance and anti dandruff activity.
Pharmacological assessment of the anti-asthmatic potential of ethanolic extract from alpinia calcarata rhizome
Authors: Chandaka Madhu 
Published: February 2025

Alpinia calcarata, commonly known as Dwarf Cardamom or Snap Ginger, is a perennial herb in the Zingiberaceae family. Various doses of the extract be administer including a dose of 2000 mg/kg and from which the low doses of 100 mg/kg and high dose was 200 mg/kg. At the high dose, no fatalities or adverse health effects were observed, indicating that the extract is well-tolerated. The positive safety profile at this dosage supports the selection of lower doses for further therapeutic evaluation. These findings suggest that the ethanolic extract possesses a favorable safety margin, positioning it as a promising candidate for subsequent pharmacological studies.
KONTRABANDA UCHUN JAVOBGARLIK TOʻGʻRISIDAGI QONUNCHILIK EVOLYUTSIYASI: TARIXIY-HUQUQIY TAHLIL
Authors: Utebaev Salamat 
Published: February 2025

Mazkur maqolada kontrabanda jinoyatining kelib chiqish tarixi xar taraflama tahlil qilingan va oʻrganilgan. Unda RSFSR va SSSR jinoyat qonunchiligi asosida mustaqil Oʻzbekiston Respublikasi jinoyat qonunchiligida kontrabanda jinoyatining kiritilish tarixi tizimli tarzda yoritilib berilgan. Shu bilan birga, kontrabanda jinoyatchilikka oid bir qator olimlarning fikrlari oʻrganilgan hamda ushbu jinoyatchilikka qarshi kurashishga oid normalarni takomillashtirish boʻyicha takliflar ilgari surilgan.
To Compare the outcome of neuromuscular therapy, active release technique and stretching among subjects with piriformis tightness
Authors: Khan Hafiza , Patil Dr. Vinaya 
Published: February 2025

Background: This study is Aim to find out the Effectiveness of Neuromuscular Therapy and Active Release Technique in females with Piriformis Tightness of Age Group 20-30 Study states that incidence of Piriformis Tightness 79.5% in health individual of India piriformis tightness has been of 6 times more in women's than in men's Because of Wider quadriceps Femoris muscle angle (Q-angle) which leads to Buttock and leg pain. Neuromuscular Therapy and Active Release technique both Treatment found Effective in Treating Piriformis Tightness, but the Comparision in Females has not done yet so to find out better choice of Treatment we conduct this study
PENERAPAN MODEL PEMBELAJARAN ROTATING TRIO EXCHANGE (RTE) UNTUK MENINGKATKAN HASIL BELAJAR PESERTA DIDIK PADA TEMA SUMBER ENERGI DI KELAS 3 UPTD SDN SIUF.
Authors: Leki Martha Bano , Akbari Ummu Fajariyah , Sunimbar  , Uslan  
Published: February 2025

Penelitian ini bertujuan untuk mengetahui penerapan model pembelajaran Rotating Trio Exchange (RTE) dalam meningkatkan hasil belajar peserta didik kelas III UPTD SD Negeri Siuf Tahun Ajaran 2023/2024. Berdasarkan hasil observasi di SDI Basadebu pada kelas III menunjukkan adanya permasalahan yang muncul dalam proses pembelajaran. Masalah yang muncul dalam kegiatan pembelajaran tersebut diantaranya bahwa dalam pembelajaran didominasi oleh guru (teacher centered), sedangkan peserta didik lebih banyak diam atau bersifat pasif. Bagaimanakah penerapan model pembelajaran Rotating Trio Exchange (RTE) untuk meningkatkan hasil belajar peserta didik di kelas III SDI Basadebu. Jenis Penelitian ini adalah Penelitian Tindakan kelas (PTK).. Teknik pengumpulan data yang digunakan adalah observasi dan tes. Instrumen penelitian yang dipakai dalam penelitian ini adalah observasi dan angket. Analisis data menggunakan data observasi untuk menghitung lembar observasi aktivitas guru dan siswa, data tes dianalisi menggunakan rata-rata nilai dan ketuntasan belajar. Hasil penelitian ini menunjukkan rata-rata peserta didik yang tuntas dalam pembelajaran siklus I mencapai 23,29 dan meningkat pada siklus II menjadi 82,35. Hal ini membuktikan bahwa pembelajaran dengan menerapkan model pembelajaran Rotating Trio Exchange (RTE) dapat meningkatkan hasil belajar peserta didik sesuai dengan KKM yaini 70 pada pembelajaran IPA materi sumber energi. Berdasarkan hasil penelitian tersebut, maka dapat disimpulkan bahwa model pembelajaran Rotating Trio Exchange (RTE) dapat meningkatkan hasil belajar peserta didik kelas III UPTD SD Negeri Siuf pada mata pelajaran IPA materi sumber energi. Berdasarkan hasil penelitian menunjukan bahwa penerapan model Rotating Trio Exchange (RTE) dalam meningkatkan hasil belajar peserta didik pada materi sumber energi di kelas III UPTD SD Negeri Siuf TahunAjaran 2023/2024.
PESAN VISUAL DAKWAH SINETRON RINDU SUARA ADZAN EPISODE KEMULIAAN SEORANG IBU KARYA SUJAEDI
Authors: Zaelani Budi , Heriyawati Yanti 
Published: February 2025

Rindu Suara Adzan yang tayang pada tahun 2023 merupakan sinetron yang memadukan unsur keagamaan dengan kehidupan masyarakat urban. Pesan-pesan yang disampaikan secara visual dan naratif dengan genre komedi religi menjadi hal penting untuk dianalisis dari sudut pandang semiotika. Tujuan kajian ini difokuskan pada analisis terhadap pesan visual baik pada bagian pembuka, maupun penutup. Analisis dengan pendekaatan teori semiotika Charles Sanders Peirce terhadap unsur ikon, index, dan symbol. Data Analisis berdasarkan tanyangan sinetron yang dapat diakses melalui youtube GTV episode tiga dengan tema Kemuliaan Seorang Ibu. Simbol pesan visual di antaranya: lampion, kubah mesjid, pintu mesjid, dan petikan ayat/hadits. Pengunaan unsur-unsur simbol tersebut direlasikan sehingga merujuk pada makna tentang nilai-nilai keislaman. Penggunaan lampion menguatkan pada nilai-nilai toleransi dan apresiasi terhadap nilai-nilai kultural. Kutipan hadits pada pesan visual penutup meyakinkan penonton atas tujuan dakwah dari sinetron tersebut.
Reviewer Acknowledgements for Journal of Education and Training, Vol. 12, No. 1
Authors: Wang Dora 
Published: February 2025

Journal of Education and Training (JET) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JET publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 12, Number 1 Antonella Nuzzaci, University of L'Aquila, ItalyBryan Spiegelberg, Rider University, USAJukdao Potisaen, Rajabhat Mahasarakham University, ThailandRania Elsayed Ibrahim, National Authority for Remote Sensing and Space Sciences, Egypt Dora WangEditorial AssistantJournal of Education and TrainingMacrothink Institute-----------------------------------------5348 Vegas Dr.#825Las VegasNevada 89108United StatesPhone: 1-702-953-1852 ext.534E-mail 1: jet@macrothink.orgE-mail 2: jet@macrothink.comWebsite: http://jet.macrothink.org
СПЕЦИФИКА ИЗОБРАЖЕНИЯ ВОЙНЫ В РОМАНЕ ВИКТОРА АСТАФЬЕВА «ПРОКЛЯТЫ И УБИТЫ»
Authors: Латышев О.Ю. , Латышева П.А. , Павлович C. , Тадич-Леско К , Радаэлли М.Э. , Луизетто М. 
Published: February 2025

В статье исследуются стилистические особенности изображения войны в романе Виктора Астафьева «Прокляты и убиты». Принимается во внимание, что именно эта книга является заключительной в его творческой биографии. В работе рассматриваются и сопоставляются различные точки зрения отечественных и зарубежных учёных на источники формирования стилистики данного художественного произведения, приводятся отличительные характеристики романа сообразно социально-политическим особенностям периода, на протяжении которого он создавался.
The article examines the stylistic features of war depiction in Victor Astafyev's novel "The Cursed and Killed", taking into account that this book is the final work in his professional biography. The paper examines and compares different perspectives of domestic and foreign scholars on the sources of stylistic formation in this literary work, and provides distinctive characteristics of the novel according to the socio-political features of the period during which it was created.
ОСОБЕННОСТИ ФОРМИРОВАНИЯ ПРОЗЫ «НА СОВРЕМЕННУЮ ТЕМУ» В ОТЕЧЕСТВЕННОМ ИСКУССТВЕ СЛОВА 60 – 70-х гг. ХХ ВЕКА (НА МАТЕРИАЛЕ АДЫГСКИХ ЛИТЕРАТУР)
Authors: Панеш У.М. , Соколова Г.В. 
Published: February 2025

Рассматриваются особенности формирования отечественной литературы 60 – 70-х годов ХХ века на материале общеадыгской прозы «на современную тему». Исследуются вопросы усиления проблемности, эволюция концепции личности, активизация психологического анализа и движение к многообразию поэтических средств. Выявляются и формулируются черты нового этапа литературного процесса, определенные культурно-историческим переменами в обществе. На основе анализа наиболее характерных и показательных произведений адыгских писателей делаются выводы об общих закономерностях формирования отечественной литературы современного периода развития. Эволюции жанров прослеживается широко – в контексте развития общероссийского художественно-эстетического процесса, что позволяет обозначить особенности литературной эпохи ХХ века.
The study examines the features of the development of Russian literature of the 60s – 70s of XX century based on the general Adyghe prose "on a modern theme". The research investigates issues of increasing problems, the evolution of the concept of personality, the activation of psychological analysis and the movement towards a variety of poetic means. The features of a new stage of the literary process, determined by cultural and historical changes in society, are identified and formulated. Based on the analysis of the most characteristic and indicative works of Adyghe writers, conclusions are made about the general patterns of the development of Russian literature in the modern period of development. The evolution of genres can be traced widely in the context of the development of the all-Russian artistic and aesthetic process, which allows us to identify the features of the literary era of the XX century.
Identification of Ferroptosis Genes Associated with Osteoarthritis Based on Bioinformatics and Machine Learning
Authors: He Zunian , Huang Xiaoban , Nie Jinyou , Qin Zhou , Lu Dinggui 
Published: February 2025

Background: Osteoarthritis (OA) is the most common joint disease, and ferroptosis is a newly discovered form of cell death linked to the pathogenesis of OA, suggesting that ferroptosis-related genes may serve as potential biomarkers. Methods: This study set out to identify differentially expressed ferroptosis-related genes (Ferr-DEGs) associated with OA by looking at the GSE55235 microarray dataset from the GEO database. We employed machine learning algorithms, along with GO and KEGG enrichment analyses, to explore the biological functions and pathways of these genes. Results: We identified a total of 119 Ferr-DEGs, and three ferroptosis-related genes, IDH2, PLIN2, and KLF2, were ultimately determined as diagnostic biomarkers for OA. We confirmed high diagnostic accuracy using ROC curve analysis. Furthermore, an analysis of immune cell infiltration showed strong links between these genes and different types of immune cells, indicating their potential roles in the immune microenvironment of OA. Conclusion: Our findings indicate that IDH2, PLIN2, and KLF2 play a key role in OA development and could serve as promising diagnostic biomarkers. Future studies with larger sample sizes will be needed to validate the roles of these ferroptosis-related genes in OA and their potential as therapeutic targets.
Cannabis use disorder and severe sepsis outcomes in cancer patients: Insights from a national inpatient sample
Authors: Sager Avinaash R , Desai Rupak , Mylavarapu Maneeth , Shastri Dipsa , Devaprasad Nikitha , Thiagarajan Shiva N , Chandramohan Deepak , Agrawal Anshuman , Gada Urmi , Jain Akhil 
Published: February 2025

BACKGROUND
The burden of cannabis use disorder (CUD) in the context of its prevalence and subsequent cardiopulmonary outcomes among cancer patients with severe sepsis is unclear.
AIM
To address this knowledge gap, especially due to rising patterns of cannabis use and its emerging pharmacological role in cancer.
METHODS
By applying relevant International Classification of Diseases, Ninth and Tenth Revision, Clinical Modification codes to the National Inpatient Sample database between 2016-2020, we identified CUD(+) and CUD(-) arms among adult cancer admissions with severe sepsis. Comparing the two cohorts, we examined baseline demographic characteristics, epidemiological trends, major adverse cardiac and cerebrovascular events, respiratory failure, hospital cost, and length of stay. We used the Pearson χ 2 d test for categorical variables and the Mann-Whitney U test for continuous, non-normally distributed variables. Multivariable regression analysis was used to control for potential confounders. A P value ≤ 0.05 was considered for statistical significance.
RESULTS
We identified a total of 743520 cancer patients admitted with severe sepsis, of which 4945 had CUD. Demographically, the CUD(+) cohort was more likely to be younger (median age = 58 vs 69, P < 0.001), male (67.9% vs 57.2%, P < 0.001), black (23.7% vs 14.4%, P < 0.001), Medicaid enrollees (35.2% vs 10.7%, P < 0.001), in whom higher rates of substance use and depression were observed. CUD(+) patients also exhibited a higher prevalence of chronic pulmonary disease but lower rates of cardiovascular comorbidities. There was no significant difference in major adverse cardiac and cerebrovascular events between CUD(+) and CUD(-) cohorts on multivariable regression analysis. However, the CUD(+) cohort had lower all-cause mortality (adjusted odds ratio = 0.83, 95% confidence interval: 0.7-0.97, P < 0.001) and respiratory failure (adjusted odds ratio = 0.8, 95% confidence interval: 0.69-0.92, P = 0.002). Both groups had similar median length of stay, though CUD(+) patients were more likely to have higher hospital cost compared to CUD(-) patients (median = 94574 dollars vs 86615 dollars, P < 0.001).
CONCLUSION
CUD(+) cancer patients with severe sepsis, who tended to be younger, black, males with higher rates of substance use and depression had paradoxically significantly lower odds of all-cause in-hospital mortality and respiratory failure. Future research should aim to better elucidate the underlying mechanisms for these observations.
Characteristics and outcomes of trauma patients with unplanned intensive care unit admissions: Bounce backs and upgrades comparison
Authors: Fokin Alexander A , Wycech Knight Joanna , Gallagher Phoebe K , Xie Justin Fengyuan , Brinton Kyler C , Tharp Madison E , Puente Ivan 
Published: February 2025

BACKGROUND
The need for an emergency upgrade of a hospitalized trauma patient from the floor to the trauma intensive care unit (ICU) is an unanticipated event with possible life-threatening consequences. Unplanned ICU admissions are associated with increased morbidity and mortality and are an indicator of trauma service quality. Two different types of unplanned ICU admissions include upgrades (patients admitted to the floor then moved to the ICU) and bounce backs (patients admitted to the ICU, discharged to the floor, and then readmitted to the ICU). Previous studies have shown that geriatric trauma patients are at higher risk for unfavorable outcomes.
AIM
To analyze the characteristics, management and outcomes of trauma patients who had an unplanned ICU admission during their hospitalization.
METHODS
This institutional review board approved, retrospective cohort study examined 203 adult trauma patients with unplanned ICU admission at an urban level 1 trauma center over a six-year period (2017-2023). This included 134 upgrades and 69 bounce backs. Analyzed variables included: (1) Age; (2) Sex; (3) Comorbidities; (4) Mechanism of injury (MOI); (5) Injury severity score (ISS); (6) Glasgow Coma Scale (GCS); (7) Type of injury; (8) Transfusions; (9) Consultations; (10) Timing and reason for unplanned admission; (11) Intubations; (12) Surgical interventions; (13) ICU and hospital lengths of stay; and (14) Mortality.
RESULTS
Unplanned ICU admissions comprised 4.2% of total ICU admissions. Main MOI was falls. Mean age was 70.7 years, ISS was 12.8 and GCS was 13.9. Main injuries were traumatic brain injury (37.4%) and thoracic injury (21.7%), and main reason for unplanned ICU admission was respiratory complication (39.4%). The 47.3% underwent a surgical procedure and 46.8% were intubated. Average timing for unplanned ICU admission was 2.9 days. Bounce backs occurred half as often as upgrades, however had higher rates of transfusions (63.8% vs 40.3%, P = 0.002), consultations (4.8 vs 3.0, P < 0.001), intubations (63.8% vs 38.1%%, P = 0.001), longer ICU lengths of stay (13.2 days vs 6.4 days, P < 0.001) and hospital lengths of stay (26.7 days vs 13.0 days, P < 0.001). Mortality was 25.6% among unplanned ICU admissions, 31.9% among geriatric unplanned ICU admissions and 11.9% among all trauma ICU patients.
CONCLUSION
Unplanned ICU admissions constituted 4.2% of total ICU admissions. Respiratory complications were the main cause of unplanned ICU admissions. Bounce backs occurred half as often as upgrades, but were associated with worse outcomes.
Asumsi Hakikat Manusia Dalam Ilmu Pendidikan
Authors: Tri Astuti  
Published: February 2025

Concepts about human nature are so diverse. Understanding the assumptions of human nature in education does not only include physical and psychological issues, but culture and other elements. Or in other words, humans are very complex creatures who need various elements in educational science to achieve success. Understanding human nature is very important in determining educational theory. History has proven that several assumptions about human nature from different points of view will determine the direction of educational theory, such as in the formation of the curriculum. The curriculum is the basis for forming character and human intelligence. This research is a qualitative descriptive research. The method used in this research is literature study. Primary data sources are journals and books related to human nature and educational science. Research validation is by triangulation. The results of the research are 1) the existence of stereotypical assumptions about human nature in education and 2) various designs and synchronization models as a form of human formation through education.