bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arbeitsunfähigkeit bei psychischen Störungen – ökonomische, individuelle und behandlungsspezifische Aspekte
Authors: Melzner Lena , Kröger Christoph 
Published: May 2024

ZusammenfassungMit den Veränderungen der modernen Arbeitswelt gehen Belastungen einher, die die psychische Gesundheit von Arbeitnehmenden negativ beeinflussen können. Im Einklang damit zeigt sich ein Anstieg des Anteils der Arbeitsunfähigkeits(AU)-Tage aufgrund von psychischen Störungen auf zuletzt 17,7 % im Vergleich zu 10,9 % im Jahr 2007, womit 2021 Kosten in Höhe von 42,9 Mrd. € aufgrund von Bruttowertschöpfungsverlusten und Produktionsausfällen verbunden waren.Dieser Artikel gibt anhand aktueller gesundheitsökonomischer Studien einen Überblick über die volkswirtschaftlichen Auswirkungen von Arbeits- und Erwerbsunfähigkeit aufgrund psychischer Störungen in Deutschland. So sind in absoluten Zahlen die Ausgaben für Arbeitsunfähigkeit insbesondere bei häufigen psychischen Erkrankungen, wie affektiven und Angststörungen, hoch. Seltenere psychische Störungen, wie die posttraumatische Belastungsstörung (PTBS) und Essstörungen, verursachen im Verhältnis zu ihrer geringen Prävalenz insbesondere hohe Kosten aufgrund von Krankengeldzahlungen.Neben diesen wirtschaftlichen Implikationen werden die Konsequenzen von Arbeits- und Erwerbsunfähigkeit sowie Arbeitslosigkeit auf individueller Ebene beleuchtet und Erklärungsansätze vorgestellt. Letztere verdeutlichen die Notwendigkeit wirksamer Behandlungsmethoden. Dabei haben sich anerkannte Therapieverfahren als effizient in der Reduktion von AU-Tagen erwiesen. Dies gilt umso mehr für arbeitsplatzbezogene Interventionen, die dahin gehend konventionellen Verfahren überlegen zu sein scheinen. Arbeitsplatzbezogene Therapieverfahren legen einen Fokus auf die Planung der Wiedereingliederung. Weitere naturalistische Studien sind nötig, um die Übertragbarkeit der Wirksamkeit der Behandlungsmodelle auf andere Störungsbilder überprüfen zu können.
Safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 685509, a soluble guanylyl cyclase activator, in healthy volunteers: Results from two randomized controlled trials
Authors: Wong Diane , Seitz Friedeborg , Bauer Verena , Giessmann Thomas , Schulze Friedrich 
Published: May 2024

AbstractThis study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of BI 685509 after oral single rising doses (SRDs) or multiple rising doses (MRDs) in healthy volunteers. In the SRD trial (NCT02694354; February 29, 2016), within each of the three dose groups (DGs), six subjects received BI 685509 (1.0, 2.5, or 5.0 mg) and two received placebo (N = 24). In the MRD trial (NCT03116906; April 17, 2017), within each of the five DGs, nine subjects received BI 685509 (uptitrated to 1 mg once daily [qd; DG1], 2.5 mg twice daily [DG2], 5.0 mg qd [DG3]; 3.0 mg three times daily [tid; DG4] or 4.0 mg tid [DG5]) and three received placebo, for 14–17 days (N = 60). In the SRD trial, 7/24 subjects (29.2%) had ≥ 1 adverse event (AE), most frequently orthostatic dysregulation (n = 4). In the MRD trial, 26/45 subjects (57.8%) receiving BI 685509 had ≥ 1 AE, most frequently orthostatic dysregulation and fatigue (each n = 12). Tolerance development led to a marked decrease in orthostatic dysregulation events (DG3). BI 685509 was rapidly absorbed after oral administration, and exposure increased in a dose-proportional manner after single doses. Multiple dosing resulted in near–dose-proportional increase in exposure and limited accumulation. BI 685509 pharmacokinetics appeared linear with time; steady state occurred 3–5 days after each multiple-dosing period. Increased plasma cyclic guanosine monophosphate and decreased blood pressure followed by a compensatory increase in heart rate indicated target engagement. BI 685509 was generally well tolerated; orthostatic dysregulation may be appropriately countered by careful uptitration.
Feasibility of virtual non-iodine coronary calcium scoring on dual source photon-counting coronary CT angiography: a dynamic phantom study
Authors: Dobrolinska Magdalena M. , Koetzier Lennart R. , Greuter Marcel J. W. , Vliegenthart Rozemarijn , van der Bie Judith , Prakken Niek H. J. , Slart Riemer H. J. A. , Leiner Tim , Budde Ricardo P. J. , Mastrodicasa Domenico , Booij Ronald , Fleischmann Dominik , Willemink Martin J. , van Straten Marcel , van der Werf Niels R. 
Published: May 2024

Abstract
Background
The aim of our current systematic dynamic phantom study was first, to optimize reconstruction parameters of coronary CTA (CCTA) acquired on photon counting CT (PCCT) for coronary artery calcium (CAC) scoring, and second, to assess the feasibility of calculating CAC scores from CCTA, in comparison to reference calcium scoring CT (CSCT) scans.

Methods
In this phantom study, an artificial coronary artery was translated at velocities corresponding to 0, < 60, and 60–75 beats per minute (bpm) within an anthropomorphic phantom. The density of calcifications was 100 (very low), 200 (low), 400 (medium), and 800 (high) mgHA/cm3, respectively. CCTA was reconstructed with the following parameters: virtual non-iodine (VNI), with and without iterative reconstruction (QIR level 2, QIR off, respectively); kernels Qr36 and Qr44f; slice thickness/increment 3.0/1.5 mm and 0.4/0.2 mm. The agreement in risk group classification between CACCCTA and CACCSCT scoring was measured using Cohen weighted linear κ with 95% CI.

Results
For CCTA reconstructed with 0.4 mm slice thickness, calcium detectability was perfect (100%). At < 60 bpm, CACCCTA of low, and medium density calcification was underestimated by 53%, and 15%, respectively. However, CACCCTA was not significantly different from CACCSCT of very low, and high-density calcifications. The best risk agreement was achieved when CCTA was reconstructed with QIR off, Qr44f, and 0.4 mm slice thickness (κ = 0.762, 95% CI 0.671–0.853).

Conclusion
In this dynamic phantom study, the detection of calcifications with different densities was excellent with CCTA on PCCT using thin-slice VNI reconstruction. Agatston scores were underestimated compared to CSCT but agreement in risk classification was substantial.

Clinical relevance statement
Photon counting CT may enable the implementation of coronary artery calcium scoring from coronary CTA in daily clinical practice.

Key Points

Photon-counting CTA allows for excellent detectability of low-density calcifications at all heart rates.

Coronary artery calcium scoring from coronary CTA acquired on photon counting CT is feasible, although improvement is needed.

Adoption of the standard acquisition and reconstruction protocol for calcium scoring is needed for improved quantification of coronary artery calcium to fully employ the potential of photon counting CT.
Accuracy of optical diagnosis with narrow band imaging in the surveillance of ulcerative colitis: a prospective study comparing Kudo, Kudo-IBD and NICE classifications
Authors: Cassinotti Andrea , Duca Piergiorgio , Maconi Giovanni , Beretta Elena , Sampietro Gianluca Matteo , Pellegrinelli Alessandro , Nebuloni Manuela , Ardizzone Sandro 
Published: May 2024

Abstract
Purpose
The diagnostic accuracy of Narrow Band Imaging (NBI) in the endoscopic surveillance of ulcerative colitis (UC) has been disappointing in most trials which used the Kudo classification. We aim to compare the performance of NBI in the lesion characterization of UC, when applied according to three different classifications (NICE, Kudo, Kudo-IBD).

Methods
In a prospective, real-life study, all visible lesions found during consecutive surveillance colonoscopies with NBI (Exera-II CV-180) for UC were classified as suspected or non-suspected for neoplasia according to the NICE, Kudo and Kudo-IBD criteria. The sensitivity (SE), specificity (SP), positive (+LR) and negative (-LR) likelihood ratios of the three classifications were calculated, using histology as the reference standard.

Results
394 lesions (mean size 6 mm, range 2–40 mm) from 84 patients were analysed. Twenty-one neoplastic (5%), 49 hyperplastic (12%), and 324 inflammatory (82%) lesions were found. The diagnostic accuracy of the NICE, Kudo and Kudo-IBD classifications were, respectively: SE 76%-71%-86%; SP 55-69%-79% (p < 0.05 Kudo-IBD vs. both Kudo and NICE); +LR 1.69-2.34-4.15 (p < 0.05 Kudo-IBD vs. both Kudo and NICE); -LR 0.43-0.41-0.18.

Conclusion
The diagnostic accuracy of NBI in the differentiation of neoplastic and non-neoplastic lesions in UC is low if used with conventional classifications of the general population, but it is significantly better with the modified Kudo classification specific for UC.
Serpentine supravenous hyperpigmentation induced by chemotherapy: a systematic review
Authors: Shan Judy , Obiakor Bianca C. , Cheng Justin , Francois Rony A. , Dobry Allison S. 
Published: May 2024

AbstractSerpentine supravenous hyperpigmentation (SSH) describes increased skin pigmentation that develops in the area immediately overlying the vessels through which chemotherapeutic drugs are administered. While SSH can be cosmetically distressing and there are no definitive management options, the literature is severely limited and the variations in clinical presentation, risk factors, and histopathology of SSH across patients are not well understood. We aimed to systematically summarize characteristics from current available data, and thus improve SSH awareness and management. A literature search was conducted in PubMed using specific eligibility criteria through the end of December 2022. Included articles focused on patients who experienced SSH after chemotherapy infusion. Study quality was assessed using a modified Oxford Centre for Evidence-Based Medicine quality rating scheme. Of the 41 articles identified by literature search, 24 met eligibility criteria. Two additional articles were identified through the reference sections of retrieved articles, for 26 articles total. All articles were case reports, representing 28 patients total. Locations of SSH were mostly in the forearm near the site of injection (85%), and the most common associated symptom was erythema. Histopathologic analysis was available for half of cases, the majority of which were inflammatory in nature. The most common inflammatory pattern observed was a vacuolar/lichenoid interface dermatitis. Duration of SSH ranged from days to > 1 year after the chemotherapy was stopped. Six (21%) patients were managed with topical steroids and oral vasodilators, six (21%) patients switched to central venous infusion rather than peripheral infusion, five (18%) patients received only supportive care, three (11%) patients received venous washing with chemotherapy, three (11%) patients stopped chemotherapy, and one (4%) patient reduced the chemotherapy dosage. Ten (36%) patients attained complete resolution, seven (25%) had SSH that was near resolution/fading, and three (11%) had persistent hyperpigmentation. Although SSH often spontaneously resolves once the chemotherapeutic agent is stopped, it can persist in some patients and cause significant distress. As the literature is severely limited and there are no definitive treatments, additional research using more standardized definitions and methods of assessments is necessary to improve characterization of SSH and evaluate potential interventions.
Practicable solution approaches for differentiated pricing of vehicle sharing systems
Authors: Müller Christian 
Published: May 2024

Abstract
Vehicle sharing systems have become increasingly popular. However, one-way vehicle sharing system providers face a major challenge. The uneven distribution of vehicles across locations caused by the uneven nature of the demand patterns poses a problem, since there are accumulations of vehicles where the demand is low. This challenge can be solved with an appropriate pricing approach that creates incentives for user-based relocation by considering supply-side network effects. While the literature mostly focuses on trip-based pricing, we were inspired by the majority of car sharing providers who use origin-based minute pricing that differentiates based on the origins of rentals, such as Share Now. Therefore, we develop two different and practicable solution approaches to determine spatially and temporally differentiated origin-based minute prices that take into account supply-side network effects. The first solution approach does not differentiate between rentals and demand and calculates continuous prices for every period and location. The second solution approach determines the vehicle distribution for each period and then calculates the optimal prices for each period backwards. Extensive computational experiments show that our solution approaches anticipate supply-side network effects and thus generate a near-optimal profit in less computational time compared to more complex benchmarks from the literature. In a sensitivity analysis we additionally show that the results are robust against stochasticity of demand and that the solution approaches perform well for different price sets.
Population normative data for OxCAP-MH capability scores
Authors: Balázs Péter György , Łaszewska Agata , Simon Judit , Brodszky Valentin 
Published: May 2024

Abstract
Aim
The study aims to establish the first set of normative data for OxCAP-MH capability instrument and to examine its association with sociodemographic and anxiety/depression severity variables.

Methods
A large-sample cross-sectional online survey was conducted among the Hungarian adult general population in 2021. OxCAP-MH standardized mean scores were compared across age, sex, education level, residence, employment, and marital status. Linear regression analysis was employed to determine the impact of sociodemographic and anxiety/depression severity on the OxCAP-MH score.

Results
In total, N = 2000 individuals completed the survey. The sample mean age was 47.1, with female majority (53.4%). Most respondents had completed primary education (51%), were active on labour market (52.4%), lived in larger cities (70.0%), and were married/in relationship (61.1%). Nearly half of the participants reported experiencing depression (48.5%), anxiety (44.3%), and 38.6% reported having both. The mean OxCAP-MH score for the total sample was 67.2 (SD = 14.4), the highest in the non-depressed (74.4) and non-anxious (73.6) subgroups, the lowest among those with extremely severe depression (45.0) and severe anxiety (47.7). Regression results indicated that older individuals (by β = 0.1), males (β = 2.3), those with secondary or higher education (β = 2.7 and 4.5) and students (β = 6.8) had significantly (p<0.01) higher mental capabilities. Respondents with mild, moderate, severe, or extremely severe depression (β =  -6.6, -9.6, -13.8, -18.3) and those with mild, moderate, or severe anxiety (β =  -4.1, -7.7, -10.3) had lower capability scores.

Conclusion
The OxCAP-MH instrument effectively differentiated capabilities across sociodemographic groups and highlighting the impact of depression and anxiety severity on general population’s mental capability.
Can dietary C:N ratio influence water quality and microbiology in recirculating aquaculture systems?
Authors: Huang Xiaoyu , Aalto Sanni L. , Dalsgaard Johanne , Pedersen Per Bovbjerg 
Published: May 2024

AbstractThe potential impacts of diet composition on water quality in recirculating aquaculture systems (RAS) have been studied only to a limited extent. This study examined the effects of different dietary C:N ratios on physiochemical water quality and associated microbiology in 12 pilot scale freshwater RAS with rainbow trout (Oncorhynchus mykiss). By adjusting the proportions of protein, carbohydrate, and fat, four diets with different C:N ratios—fully embracing the span observed in commercial diets—were formulated (CN8.5, CN9.3, CN10.0, and CN12.2). Each diet was administered to three separate RAS for 4 weeks at a daily feed loading of 1.67 kg/m3 make-up water. At the end of the trial (in week 4), concentrations of nitrite-N, nitrate–N, and dissolved COD, and microbial activity were significantly lower and water clarity was simultaneously higher in systems fed the CN12.2 diet as compared to the other diets. Microbial community compositions in system water and biofilter biofilms and the overall microbial abundance in system water were not affected. This was likely due to the molar C:N ratios in system water not correlating to the dietary C:N ratios and being very low (0.27–0.34) throughout all dietary C:N levels, suggesting that microorganisms were carbon limited in all RAS. Altogether, the results demonstrate that changing dietary C:N ratios can affect physicochemical water quality and microbial activity in RAS. In contrast, changing dietary C:N ratios did not affect water C:N ratios or water or biofilter microbial community composition at least within the span of dietary C:N ratios observed for commercial juvenile rainbow trout feeds.
Unscrambling the Dynamics of Danger: Scientific Foundations and Evidence for the Looming Vulnerability Model and Looming Cognitive Style in Anxiety
Authors: Riskind John H. 
Published: May 2024

Abstract
Background
A revised looming vulnerability model is described that updates the original conceptual model and synthesizes new findings and evidence. The revised model extends the notion of dynamic threat by describing the role of cognitive-perceptual distortions. Moreover, it suggests that dynamic threat perceptions, particularly that threats are approaching, serve as warning signals that lower the threshold for appraising threat, influencing negative emotional responses (primarily but not only anxiety and fear), cognitive-affective processing, behavior, and maladaptive coping. Individual differences in “looming cognitive style” can lead to transdiagnostic vulnerability to anxiety (and less so, to depression), maladaptive defensive reactions, cognitive-affective (experiential) avoidance, and stress generation.

Methods
This article reviews the conceptualization proposed by the revised looming vulnerability model, and comprehensively reviews its scientific foundation, and current supporting evidence that has accrued for the model across diverse research domains.

Results
The revised conceptualization of the looming vulnerability model is amply supported by the accumulated research, which highlights the importance of dynamic stimuli for attention, memory, emotional, and neurological response. Likewise, the looming cognitive style is supported by a substantial number of studies, linking it to cognitive vulnerability to anxiety, biased threat processing, maladaptive coping and cognitive-affective avoidance, and developmental antecedents.

Conclusions
The review of evidence supports the revised looming vulnerability model's tenets about the importance of dynamic stimulusi features, which previous models have neglected, and of the looming cognitive style, which is proposed as a distinct cognitive vulnerability Clinical implications and future research directions are discussed.
State-corporate legal symbiosis and social harm: the case of the steel factory ‘Ilva’ in Taranto, Italy
Authors: Nicoli Aldini Carlo 
Published: May 2024

AbstractFor more than a decade, epidemiological surveys have shown that Taranto, Italy, has a critical health situation. In particular, two epidemiological reports have established a causal link between mortality and morbidity in Taranto and the industrial production of Ilva, one of Europe’s largest steel mills. Despite its negative impact on local health, Ilva has been allowed to produce thanks to a favorable legal framework. In particular, this article focuses on seven years central to the recent history of Ilva (2011–2017), in which the state has engaged in frenetic and compulsive lawmaking aimed to establish a favorable legal environment for Ilva to continue producing. It shows how the law has become an avenue for the Italian state and Ilva to establish a symbiotic relationship that has created the conditions to produce and reproduce harmful corporate practices. These laws are presented in juxtaposition with academic research and epidemiological surveys on Taranto’s public health, thus showing how the Italian state has responded to the increasing amount of evidence of corporate harm done in Taranto. The article contributes to the criminological scholarship on state-corporate crime and social harm by discussing the role of state law in the production and reproduction of harmful corporate practice. It also advances the literature on the Ilva case with a novel socio-legal reading of the socioenvironmental conflict ongoing in Taranto.
Enhancing student engagement through emerging technology integration in STEAM learning environments
Authors: Maričić Mirjana , Lavicza Zsolt 
Published: May 2024

AbstractEmerging technologies can potentially transform education through student engagement. The aim of our study is threefold. Firstly, we aspired to examine the validity and reliability of Reeve and Tsengs’ 4-construct (emotional, behavioral, cognitive, and agentic) engagement scale (EBCA scale). Secondly, we aimed to examine whether and to what extent the integration of emerging technology through virtual simulations (VS) in STEAM activities can improve students’ perceived engagement. Thirdly, we strived to examine how the order of integration of VS in STEAM activities affects students’ perceived engagement. A cross-over research design was used. 84 primary school students (9–10 years old) were assigned to one of the following conditions: STA (science + technology + art); SA (science + art); STA + SA; and SA + STA. The results showed that the 4-factor EBCA scale model is aligned and fits the overall sample well. It was also observed that the longer students are involved in STEAM activities, the better their perceived engagement is, and the more they work on VS, the more they develop the values of attentive listening, directing attention, and investing effort in learning. The order of integration of VS affects perceived engagement, and students who learn with them first perceive engagement better. One of the implications of our study is to examine the metric characteristics of the EBCA scale on different samples as well. Other recommendations are stated in the discussion.
Household debt and financial vulnerability: empirical evidence for Spain, 2002–2020
Authors: Martín-Legendre Juan Ignacio , Sánchez-Santos José Manuel 
Published: May 2024

AbstractThe aim of this paper is to analyse the evolution of Spanish households’ indebtedness and financial vulnerability over the course of this century using micro-data from the Household Finance and Consumption Survey. Our results show a growing debt participation of Spanish households and an increase in the stock of outstanding debt of indebted households, a trend that reversed with the end of the Great Recession. Moreover, the percentage of financially vulnerable households according to three indicators grew dramatically until the end of the downward phase of the last economic cycle and showed considerable signs of improvement during the second half of 2010s. These results, nonetheless, call attention to the number of Spanish households being unable to service their debts in the face of an economic downturn.