bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aggregatibacter Aphrophilus as a Rare Cause of Endogenous Endophthalmitis
Authors: Kanda Pushpinder , Kundapur Deeksha , Chen Henry , Dollin Michael 
Published: June 2024

Purpose:
To describe a rare case of endogenous endophthalmitis caused by Aggregatibacter aphrophilus (A. aphrophilus) in context of all previously reported cases of endophthalmitis caused by this organism.

Methods:
A 59-year-old male with no history of ocular trauma or surgery presented with a red, painful right eye with light perception vision. Examination showed a hypopyon, dense fibrin reaction, and cells in the anterior chamber. B-scan ultrasound showed evidence of vitritis. Broad investigations were initiated for both inflammatory and infectious etiologies.

Results:
The patient was diagnosed with presumed endogenous bacterial endophthalmitis as the blood cultures was positive for A. aphrophilus and vitreous cultures were negative for growth. The patient was promptly treated with intravitreal and systemic antibiotics and later underwent pars plana vitrectomy. The final visual acuity was 20/50. The patient had a prosthetic aortic valve and careful investigations had ruled out endocarditis.

Conclusions:
This case emphasizes the importance of early recognition, investigation, and intervention for A. aphrophilus endophthalmitis including the role of therapeutic vitrectomy. While early presentation can mimic ocular inflammatory diseases, infection from under-recognized causative organisms like A. aphrophilus, should be ruled out. Systemic and intraocular antibiotics should be started promptly in order to provide the best visual prognosis.
Social support and the association between post-traumatic stress disorder and risk for long-term prescription opioid use
Authors: Sullivan Mark D. , Wilson Lauren , Amick Matthew , Miller-Matero Lisa R. , Chrusciel Timothy , Salas Joanne , Zabel Celeste , Lustman Patrick J. , Ahmedani Brian , Carpenter Ryan W. , Scherrer Jeffrey F. 
Published: June 2024

Abstract
Post-traumatic stress disorder (PTSD) is common in patients with chronic pain, adversely affects chronic pain outcomes, and is associated with opioid use and adverse opioid outcomes. Social support is a robust predictor of PTSD incidence and course as well as chronic pain outcome. We determined whether the association between PTSD and persistent opioid use was modified by emotional support in a cohort of patients receiving opioids for noncancer pain. Eligible participants were ≥18 years and had completed a new period of prescription opioid use lasting 30 to 90 days. Bivariate associations between cohort characteristics and each key variable was assessed using χ2 tests for categorical variables and t-tests for continuous variables. Interaction between PTSD and emotional support was assessed by a priori stratification on low vs high emotional support. Participants (n = 808) were 53.6 (SD ± 11.6) years of age, 69.8% female, 69.6% White, and 26.4% African American. Overall, 17.2% had probable PTSD. High emotional support was significantly (P < 0.0001) more common among those without probable PTSD. Prescription opioid use at 6-month follow-up was significantly (P = 0.0368) more common among patients with vs without probable PTSD. In fully adjusted models, PTSD was no longer associated with opioid use at 6-month follow-up among participants with high emotional support. Among those with lower emotional support, PTSD was significantly associated with opioid use at 6-month follow-up in unadjusted (odds ratio = 2.40; 95% confidence interval: 1.24-4.64) and adjusted models (odds ratio = 2.39; 95% confidence interval: 1.14-4.99). Results point to the hypothesis that improvement of emotional support in vulnerable patients with chronic pain and PTSD may help reduce sustained opioid use.
Psychometric Testing of the Thai Version of Self-Care of Chronic Illness Inventory Version 4c in Patients With Stroke
Authors: Srisomthrong Kannika , Suwanno Jom , Klinjun Nuntaporn , Suwanno Juk , Kelly Matthew 
Published: June 2024

Background
Self-Care of Chronic Illness Inventory version 4c is a non–disease-specific self-care measure used in individuals with multiple chronic conditions. This instrument may be applied to patients with specific diseases such as stroke.

Objective
The aim of this study was to evaluate the psychometric properties of the Thai version of the Self-Care of Chronic Illness Inventory version 4c in patients with stroke.

Methods
This multicenter, cross-sectional study adhered to the COSMIN (Consensus-based Standards for the Selection of Health Measurement Instruments) guidelines and enrolled patients with stroke from 16 primary care centers in southern Thailand. Structural validity was assessed using confirmatory factor analysis, internal consistency reliability using Cronbach α coefficient and global reliability index, and test-retest reliability using intraclass correlation coefficients.

Results
The final analysis included a total of 350 participants. Confirmatory factor analysis supported the 2-factor Self-Care Maintenance scale structure, although the item allocation to the dimensions differed from that of the original model. The Self-Care Monitoring scale demonstrated a 1-factor structure with permitted residual covariance. The Self-Care Management scale maintained a 2-factor structure, similar to that of the original model. Simultaneous confirmatory factor analysis of the combined items supported the general model with the 3 scales. The Self-Care Maintenance scale exhibited marginally adequate α (0.68) and ω (0.66) coefficients, and an adequate composite reliability index (0.79). The other 2 scales demonstrated adequate α (range, 0.79–0.86), ω (range, 0.75–0.86), and composite reliability (range, 0.83–0.86) indices. Intraclass correlation coefficients showed adequate test-retest reliability for all scales (range, 0.76–0.90).

Conclusions
The generic self-care measure, Self-Care of Chronic Illness Inventory version 4c, demonstrated strong psychometric properties in patients with stroke. This instrument may be a valuable tool for assessing stroke self-care in Thailand.
Assessing Krenning’s score on 68Ga-DOTATATE PET-CT and miPSMA score on 68Ga-PSMA-11 PET-CT in TENIS: a comparison with FDG PET/CT and examining the feasibility of targeted radionuclide therapy
Authors: Sonavane Sunita , Salvi Omkar , Asopa Ramesh V. , Basu Sandip 
Published: June 2024

Objectives
The objective of this study was to assess receptor expression in metastatic differentiated thyroid carcinoma patients with progressive elevated thyroglobulin and negative iodine scintigraphy, we used 68Ga-DOTATATE [Gallium-68 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA)–octreotate (DOTATATE)] (Krenning’s score) and 68Ga-PSMA-11 (Gallium-68 prostate‐specific membrane antigen‐11) PET-computed tomography (CT) [molecular imaging prostate‐specific membrane antigen (miPSMA) score]. Patients with Krenning’s score 3 and above and miPSMA score 2 and above were considered to determine the incidence of patients, who would qualify for treatment with 177Lu-DOTATATE/PSMA [Lutetium-177 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA)–octreotate (DOTATATE)/prostate‐specific membrane antigen]-based therapy. In addition, we compared 68Ga-DOTATATE and 68Ga-PSMA-11 PET-CT with 2-deoxy-2-[F-18]fluoroglucose (18F-FDG) PET-CT (using maximum standardized uptake value).

Materials and methods
A total of 74 patients with histopathologically proven metastatic differentiated thyroid carcinoma with thyroglobulin elevation and negative iodine scintigraphy syndrome were studied retrospectively. They all had 18F-FDG, 68Ga-DOTATATE, and 68Ga-PSMA-11 PET-CT scans available for undertaking this analysis. The lesions detected by 68Ga-DOTATATE and 68Ga-PSMA-11 were evaluated using Krenning’s and miPSMA scores. In addition, quantitative comparisons of maximum standardized uptake values for 68Ga-DOTATATE and 68Ga-PSMA-11, as well as with 18F-FDG, were conducted.

Results
Patient-wise analysis revealed positivity rates of 40.5% for 68Ga-DOTATATE, 41.89% for 68Ga-PSMA-11, and 75.67% for 18F-FDG. Among the 74 patients, 14 (18.91%) were deemed eligible for 177Lu-DOTATATE/PSMA-617 therapy based on Krenning’s score of 3 and above both/either miPSMA score of 2 and above on 68Ga-DOTATATE or 68Ga-PSMA-11 PET-CT. Within this subgroup, seven out of 74 patients (9.45%) were eligible for 177Lu-DOTATATE therapy, and nine out of 74 patients (12.16%) were eligible for 177Lu-PSMA-targeted therapy. Four patients were eligible for both therapies.

Conclusion
Among thyroglobulin elevation and negative iodine scintigraphy patient’s subgroup, 9.45% could qualify for 177Lu-DOTATATE and 12.16% for 177Lu-PSMA-617. Four were eligible for both therapies. Given the lack of effective therapies, this subset of patients warrants consideration for radionuclide therapy exploration.
Successful Treatment of Refractory or Relapsed Hepatoblastoma With Autologous Hematopoietic Stem Cell Transplantation in Children
Authors: Kim Bo Kyung , Choi Jung Yoon , Hong Kyung Taek , Park Hyun Jin , Kang Hyoung Jin 
Published: June 2024

Background:
The standard-risk hepatoblastoma has a good prognosis in children; however, refractory or relapsed (R/R) hepatoblastoma has a poor prognosis and high mortality rate. This study aimed to demonstrate the efficacy of high-dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT) rescue in pediatric patients with R/R hepatoblastoma.

Methods:
We retrospectively analyzed 6 pediatric patients with R/R hepatoblastoma who underwent autologous HSCT. The MEC conditioning regimen was used for all patients, comprising melphalan 140 mg/m2/day intravenously (IV) on day 7 and 70 mg/m2 on day 6, etoposide 200 mg/m2 IV on days 5 to 8, and carboplatin 400 mg/m2 IV on days 5 to 8. One patient received a TopoThioCarbo regimen, comprising topotecan 2 mg/m2/day IV on days 4 to 8, thiotepa 300 mg/m2/day IV on days 6 to 8, and carboplatin 500 mg/m2/day IV on days 3 to 5, as the conditioning regimen for the first transplantation. This was followed by salvage chemotherapy for relapse, and the second transplantation was performed using MEC as the conditioning regimen.

Results:
We report the retrospective results of 6 patients with a median age of 1.8 (range 0.4 to 10.2) years who had R/R hepatoblastoma and underwent autologous HSCT. The median follow-up period was 58 (range 28 to 113) months after diagnosis. The median stage at diagnosis was 2.0 (range 2 to 4). Two patients had lung metastases during diagnosis. The median initial alpha-fetoprotein level was 292,888 (range 28,831 to 2,406,942) ng/mL, and the median number of chemotherapy lines before autologous HSCT was 3.5 (range 2 to 7). The disease status before HSCT was complete remission (CR) for all patients. The engraftment rate was 100%. No treatment-related mortality was reported. The 3-year event-free survival and overall survival rates were 83.3% and 100%, respectively. One patient relapsed after the second HSCT and achieved CR after salvage chemotherapy.

Conclusion:
This study suggests autologous HSCT as an effective treatment in pediatric patients with R/R hepatoblastoma. Nevertheless, future large-scale prospective studies are warranted.
Effect of Spirituality on Psychological Resilience and Hope in Patient-Family Caregiver Dyads Experiencing Gynecological Cancer
Authors: Yildiz Tulay , Uslu-Sahan Fatma 
Published: June 2024

BackgroundWomen experiencing gynecological cancer (GCPs) and family caregivers (FCGs) use spirituality to cope with cancer. However, the dual relationship between the impact of spirituality on psychological resilience and hope among both GCPs and FCGs has not yet been explored.ObjectiveTo examine the interdependent relationship between spirituality, psychological resilience, and hope of women with gynecological cancer and their FCGs at the dyadic level.MethodsIn this cross-sectional study, 107 dyads were recruited from the gynecological oncology departments of 2 university hospitals in Ankara, Turkey. The GCPs and FCGs completed a Patient/Family Caregiver Information Form, Spiritual Well-being Scale, Connor-Davidson Resilience Scale, and Dispositional Hope Scale. Data were analyzed using descriptive statistics and Pearson’s correlations. This study used the Actor-Partner Interdependence Model.ResultsSpirituality of both GCPs and FCGs had a significant positive effect on their psychological resilience (B= 0.918,P< .001;B= 0.435,P< .001, respectively) and hope (B= 0.350,P< .001;B= 0.246,P< .001, respectively). However, the spirituality of GCPs and FCGs did not have a partner effect on psychological resilience (B= −0.150,P< .052;B= −0.150,P= .052, respectively) and hope (B= −0.012,P= .810;B= 0.073,P= .157, respectively).ConclusionsSpirituality of GCPs and their FCGs positively affected their psychological resilience and hope, but the effect on each other was limited.Implications for PracticeHealth professionals, especially nurses, should focus on tailoring spiritual care interventions to the unique needs of each individual within the GCP and FCG dyads. Personalized approaches that recognize and address the specific spiritual concerns of patients and caregivers may be more effective in promoting psychological resilience and hope.
Perforation of the Heart During Elective Removal of an Inferior Vena Cava Filter
Authors: Desai Sapna P. , Yu Christine Z. , Evangelista Frank , Gill James R. 
Published: June 2024

Abstract
A common treatment for venous thromboembolic disease in patients with contraindications to anticoagulation includes placement of an inferior vena cava (IVC) filter. Temporary filters are available to avoid the risk of long-term permanent placement. A woman in her 60s with a history of uterine serous carcinoma presented to the emergency department with cardiac arrest following elective attempted IVC filter removal. Three months prior, a temporary filter was placed because anticoagulation medication was stopped in preparation for a hysterectomy. During the IVC retrieval procedure, which was performed using an intravascular approach from the right jugular vein, the filter was tilted, requiring the use of a different retrieval sheath. During catheter reentry, the patient complained of discomfort in the chest and neck, after which she became hypotensive, lost consciousness, and died. Autopsy revealed 2 cardiac perforations, one in each ventricle. Approximately 600 mL of liquid and clotted blood was within the tense pericardial sac. An IVC filter was found in place, with no adjacent hemorrhage.
To our knowledge, this is the first reported fatality due to cardiac perforation by an access sheath during intravascular removal of an IVC filter. This instance also documents the time course of the cardiac perforations to the resultant loss of consciousness.
Change in Nutrition and Physical Activity Practices in Early Childcare and Education Settings in Illinois During the COVID-19 Pandemic
Authors: Schermbeck Rebecca M. , Lin Yu Chen , Leider Julien , Simon Janna , Chriqui Jamie 
Published: June 2024

Context:
For many young children, early childcare and education (ECE) programs are the only source of nutritious meals and physical activity (PA); however, the COVID-19 pandemic led to program closures, restrictions, and changed practices.

Objective:
To examine changes in nutrition and PA-related best practices in ECE settings in Illinois from 2019, just prior to the pandemic, as compared to 2022. We also examined how changes over time varied by program type (ie, centers vs homes), Child and Adult Care Food Program (CACFP) status, and/or Head Start/Early Head Start status.

Design:
The study design is a repeated cross-sectional survey administered in December 2019 and October 2022.

Setting:
State of Illinois.

Participants:
A total of 888 and 1162 ECE providers completed initial and follow-up surveys, respectively.

Intervention:
NA

Main Outcome Measure:
Provider report of meeting 14 nutrition and 9 PA-related best practices.

Results:
Overall, 9 nutrition-related best practices were maintained and 5 declined over time. Centers, CACFP, and Head Start providers reported significant declines in meeting nutrition-related practices over time. A total of 8 PA-related best practices were maintained and 1 declined over time. Centers reported a significant decline in 5 of the PA-related best practices over time, and these declines were significantly different than in homes over time. Similarly, Head Start programs reported a decline in 4 PA-related best practices over time, and the change was significantly different from non-Head Start programs in 3 of the 4 practices.

Conclusion:
The findings of this study should be considered a new baseline for ECE nutrition and PA-related best practices in Illinois and should serve as a wake-up call for advocates nationwide with regard to the provision of nutrition and PA-related best practices in centers and by CACFP and Head Start providers postpandemic.
Choice of antiretroviral therapy has low impact on weight gain
Authors: Drechsler Henning , Ayers Colby , Oboho Ikwo , Enwerem Ngozi , Hanna John , Clark Christopher , Kitchell Ellen , Jain Mamta , Luque Amneris , Bedimo Roger 
Published: June 2024

Objective:
Antiretroviral therapy (ART) containing integrase inhibitors (INSTIs) and/or tenofovir alafenamide (TAF) has been associated with greater weight gain. Yet few studies have delineated between exposure to ‘anchor’ drugs [protease inhibitors (PI), nonnucleoside reverse transcriptase inhibitors (NNRTI) or INSTIs] and exposure to nucleoside reverse transcriptase inhibitors (NRTIs).

Design:
In this cohort of antiretroviral drug-naive patients who initiated ART from 2008–2022, we analyzed BMI gain for eight contemporary ‘anchor’ drugs and three contemporary NRTIs during the first 3 years of ART. We censored patients if they stopped, switched, or added another antiretroviral drug to their regimen.

Methods:
We used generalized estimating equations (GEE) to assess the association between BMI gain and choice of ART and a nonlinear mixed model for the marginal coefficients of determination. We adjusted for time, baseline demographic and HIV-characteristics, and time-updated HIV and substance use-related variables.

Results:
The median BMI gain in 4 194 patients over 3 years was + 1.9 kg/m2 [interquartile range (IQR) 0.1–4.1]. Most patients were black (55%) and men (77%). Multivariable modeling from 20 528 BMI measurements revealed that the type of ART accounted for just 9% of the predicted BMI change. Only efavirenz (EFV) and tenofovir disoproxil fumarate (TDF) were independently associated with (lower) weight gain but no differences were observed between INSTIs, PIs, and rilpivirine, or between TAF and abacavir.

Conclusion:
The choice of initial ART had little impact on weight gain. INSTIs or TAF were not independently associated with weight change after ART initiation, but EFV and TDF were.
Public-private mix in health systems and repercussions for health inequalities in Latin American countries: a scoping review protocol
Authors: dos Anjos Eduarda Ferreira , de Oliveira Suelen Carlos , Mendoza-Ruiz Adriana , del Pilar Flores-Quispe Maria , Mendes Pereira Adelyne Maria , Kendall Carl , Sansigolo Kerr Ligia Regina Franco , Ortelan Naiá , Pinto Junior Elzo Pereira , Romero Natalia , Leyland Alastair , Barreto Mauricio Lima , Machado Cristiani Vieira 
Published: June 2024

AbstractIntroductionHealth system models in Latin American countries express differences in the state’s role in regulating, financing and providing health services, as well as in the coexistence of different care arrangements involving public and private entities. This scoping review will seek to identify evidence on how the different public-private configurations of health systems influence health inequalities in Latin America.Methods and AnalysisThis protocol will be guided by the scoping review methodology developed by the Joanna Briggs Institute. The results will be presented according to the PRISMA-ScR protocol. Searches will be carried out on the Scielo, Lilacs, Embase, Pubmed, Web of Science and Scopus databases. The inclusion criteria will be publications whose central theme is the public-private mix of health systems in Latin America between January 2000 and March 2024. Exclusion criteria will be clinical trials, incomplete studies or in the design phase, duplicate publications, pre-print studies and gray literature (interim reports, unpublished texts, dissertations, and theses. The steps for carrying out the scope review will: (1) identifying the research question; (2) identifying relevant studies; (3) study selection; (4) charting the data; and (5) collating, summarizing, and reporting the results. Two independent reviewers will select the articles. The results will be described, analyzed, and categorized through narrative synthesis, correlating with the research objectives and questions.Expected resultsIt is hoped that this scoping protocol will provide a comprehensive framework for investigating the gaps in the current literature on the public-private mix in Latin America and the effects on health inequalities.Link to the protocol record in the Open Science Framework (OSF)https://osf.io/rkzx3/?view_only=4594a2c52f2d47128d805fdd9dd1359b.
MpoxPlex: a high-throughput and versatile multiplexed immunoassay for assessing and discriminating between IgG responses to Mpox infection and vaccination
Authors: Jones Scott , Hicks Bethany , Callaby Helen , Bailey Daniel , Gordon Claire , Rampling Tommy , Houlihan Catherine , Jones Rachael , Pond Marcus , Mehta Ravi , Wright Deborah , Oeser Clarissa , Tonge Simon , Linley Ezra , Rowe Cathy , Hallis Bassam , Otter Ashley 
Published: June 2024

AbstractThe summer of 2022 saw the first global outbreak of Mpox disease (formerly ‘monkeypox’), primarily within gay, bisexual, and other men who have sex with men (GBMSM). In response, public health agencies in the UK have offered smallpox vaccines to those individuals deemed at highest risk of infection. With Mpox cases still being detected globally, novel tools are required to aid with diagnosis, serosurveillance and the evaluation of immune responses following infection and vaccination. Here, we describe the development of a multiplexed immunoassay that is able to measure IgG responses to twelve immunogenic Orthopoxvirus proteins concurrently and distinguish between responses to infection and vaccination.Using the Luminex platform, antibody responses to vaccinia virus (VACV) proteins B5, A27, A33 and Monkeypox virus (MPXV) proteins E8, B6, B2, M1, A27, A35, H3, A29, A5 were assessed in serum from individuals post-MPXV infection (n=24) and post-vaccination (n=75) with modified vaccinia virus Ankara-Bavarian Nordic (MVA-BN, “IMVANEX”). Negative sera (n=435) were run alongside to assess appropriate assay cut-offs and characteristics.Using the results from a combination of eight of the twelve proteins within the immunoassay we were able to classify samples as either post-vaccination or infection, from negative samples with a sensitivity of 98.39% (9.72-99.22%) and specificity of 95.24% (86.91-98.70%). IgG responses to VACV A27, MPXV A29 and MPXV A5 provided little diagnostic advantage. IgG responses to the MPXV protein A27 were able to distinguish post-MPXV infection from negative and post-vaccination samples with a sensitivity of 87.5% (69.00-95.66%) and specificity of 96.84% (94.84-98.07%).There is an ongoing need to utilise Mpox serology to conduct disease surveillance, assess the efficacy of current and new vaccine candidates, and further understand immune responses to Mpox infection. We believe this assay will provide substantial insight into the current global outbreak of Mpox, with additional benefits over current serological assays.