bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion‐weighted magnetic resonance imaging detection of renal cancer presenting with diffuse peritoneal metastases in a patient with hemodialysis‐associated acquired cystic disease of the kidney
Authors: Kitazume Yoshio , Satoh Shiro , Taura Shinichi , Kimula Yuji 
Published: March 2009

AbstractA 59‐year‐old man was admitted with a large amount of ascites, cake‐like omental thickening, and dialysis‐associated acquired cystic disease of the kidney (ACDK). It was difficult to detect renal cancer, which was revealed as a primary site of peritoneal metastases by autopsy, with conventional cross‐sectional imaging, such as enhanced computed tomography and T2, T1, and dynamic gadolinium‐enhanced T1‐weighted magnetic resonance imaging, because multiple renal cysts caused marked distortion of the renal parenchyma and the cancer had necrosis. We demonstrated the usefulness of diffusion‐weighted imaging with a high b‐factor to detect renal cancer presenting with peritoneal metastasis in a patient with ACDK. J. Magn. Reson. Imaging 2009;29:953–956. © 2009 Wiley‐Liss, Inc.
Neuroimaging assessment of memory‐related brain structures in a rat model of acute space‐like radiation
Authors: Huang Lei , Smith Anna , Cummings Peter , Kendall Edward J. , Obenaus Andre 
Published: March 2009

AbstractPurposeTo investigate the acute effects on the central nervous system (CNS) of 56Fe radiation, a component of high‐energy charged particles (HZE) in space radiation, using quantitative magnetic resonance imaging (MRI) noninvasively.Materials and MethodsSprague–Dawley rats were exposed to whole‐brain 56Fe (0, 1, 2, and 4 Gy). At 1 week postirradiation, MRI scans were made using T2‐weighted (T2WI), diffusion‐weighted (DWI), and contrast enhanced T1‐(CET1) imaging. T2 relaxation time and apparent diffusion coefficient (ADC) values were obtained from memory‐related brain regions of interest (ROIs). Histopathology was correlated using ex vivo tissues.ResultsNo overt abnormalities were visualized using T2WI and DWI at 1 week postradiation. CET1 values did not differ significantly between the irradiated and control animals. Compared to 0 Gy, there were significant prolongations in T2 values and reductions in ADC after irradiation. In the absence of evident neuronal pathology, immunohistochemistry revealed astrocytic activation in 4 Gy animals.ConclusionAt 1 week after whole‐brain 56Fe exposure, T2 and ADC values can differentiate radiosensitivity in regions critical for hippocampal‐related memory. MRI may provide noninvasive assessment of the initial molecular/cellular disturbances in vivo after HZE irradiation. J. Magn. Reson. Imaging 2009;29:785–792. © 2009 Wiley‐Liss, Inc.
Use of ultrasmall superparamagnetic particles of iron oxide (USPIO)‐enhanced MRI to demonstrate diffuse inflammation in the normal‐appearing white matter (NAWM) of multiple sclerosis (MS) patients: An exploratory study
Authors: Vellinga Machteld M. , Vrenken Hugo , Hulst Hanneke E. , Polman Chris H. , Uitdehaag Bernard M.J. , Pouwels Petra J.W. , Barkhof Frederik , Geurts Jeroen J.G. 
Published: March 2009

AbstractPurposeTo explore ultrasmall superparamagnetic particles of iron oxide (USPIO) as a marker for diffuse inflammation in multiple sclerosis (MS) normal‐appearing white matter (NAWM), using quantitative MRI. Disease activity in the NAWM of MS patients partly explains why MRI lesion burden correlates only moderately with disability. USPIO have been shown to visualize the cellular component of inflammation in focal MS lesions. In this study, we aimed to explore USPIO as a marker for the more diffuse inflammation in MS NAWM, using quantitative MRI.Materials and MethodsIn this prospective MRI study, 16 MS patients (eight relapsing‐remitting MS [RRMS] and eight primary‐progressive MS [PPMS] cases) and five healthy control (HC) subjects were included. Using a flip‐angle (FA) array, B1‐corrected T1 maps were generated before and 24 hours after USPIO (SHU555C) injection. White‐matter (WM) T1 histogram and region‐of‐interest (ROI) characteristics were compared between both time points using Wilcoxon signed‐rank test.ResultsBoth NAWM ROI and histogram analyses showed T1 shortening after USPIO injection in MS patients (P < 0.01), but not in HCs (P = 0.68).ConclusionThis exploratory study suggests that USPIO‐enhanced MRI may be a new potential marker for subtle inflammatory activity in MS NAWM. Further studies should focus on relating diffuse inflammation to clinical disease activity and treatment efficacy. J. Magn. Reson. Imaging 2009;29:774–779. © 2009 Wiley‐Liss, Inc.
Diffusion tensor and tensor metrics imaging in intracranial epidermoid cysts
Authors: Santhosh Kannath , Thomas Bejoy , Radhakrishnan Vishnupuri V. , Saini Jitender , Kesavadas Chandrasekharan , Gupta Arun Kumar , Kapilamoorthy Tirur Raman , Nair Suresh N. 
Published: March 2009

AbstractPurposeTo explore the utility of diffusion tensor imaging (DTI) and diffusion tensor metrics (DTM) in characterizing the structural pathology of epidermoid cysts. DTI gives information about the tissue structure; a high fractional anisotropy (FA) indicates a highly structured orientation of the tissue, fibers, or white matter tracts. Based on the tensor rank, a set of three metrics has been described that can be used to measure the directional dependence of diffusion: linear anisotropy (CL), planar anisotropy (CP), and spherical anisotropy (CS). DTM takes into account the shape of diffusion anisotropy and hence may provide better insight into the orientation of structures than FA.Materials and MethodsDTI was performed in three patients with epidermoid cysts. FA, directionally‐averaged mean diffusivity (Dav), exponential apparent diffusion coefficient (eADC), and DTM, such as CL, CP, and CS, were measured from the tumor core as well as from the normal‐appearing white matter. Histopathological correlation was obtained.ResultsEpidermoid cysts showed high FA with Dav values similar to that of normal white matter. eADC maps did not show any restriction of diffusion. FA values were high, but not as high as that for the white matter. CP values were higher and CL values were lower than those obtained for the white matter in various regions.ConclusionHigh CP values suggest preferential diffusion of water molecules along a two‐dimensional geometry, which could be attributed to the well‐structured orientation of keratin filaments and flakes within the tumor as demonstrated by histopathology. Advanced imaging modalities like DTI with DTM can provide information regarding the microstructural anatomy of the epidermoid cysts. J. Magn. Reson. Imaging 2009;29:967–970. © 2009 Wiley‐Liss, Inc.
Comparison of fMRI data from passive listening and active‐response story processing tasks in children
Authors: Vannest Jennifer J. , Karunanayaka Prasanna R. , Altaye Mekibib , Schmithorst Vincent J. , Plante Elena M. , Eaton Kenneth J. , Rasmussen Jerod M. , Holland Scott K. 
Published: March 2009

AbstractPurposeTo use functional MRI (fMRI) methods to visualize a network of auditory and language‐processing brain regions associated with processing an aurally‐presented story. We compare a passive listening (PL) story paradigm to an active‐response (AR) version including online performance monitoring and a sparse acquisition technique.Materials and MethodsTwenty children (ages 11–13 years) completed PL and AR story processing tasks. The PL version presented alternating 30‐second blocks of stories and tones; the AR version presented story segments, comprehension questions, and 5‐second tone sequences, with fMRI acquisitions between stimuli. fMRI data was analyzed using a general linear model approach and paired t‐test identifying significant group activation.ResultsBoth tasks showed activation in the primary auditory cortex, superior temporal gyrus bilaterally, and left inferior frontal gyrus (IFG). The AR task demonstrated more extensive activation, including the dorsolateral prefrontal cortex and anterior/posterior cingulate cortex. Comparison of effect size in each paradigm showed a larger effect for the AR paradigm in a left inferior frontal region‐of‐interest (ROI).ConclusionActivation patterns for story processing in children are similar in PL and AR tasks. Increases in extent and magnitude of activation in the AR task are likely associated with memory and attention resources engaged across acquisition intervals. J. Magn. Reson. Imaging 2009;29:971–976. © 2009 Wiley‐Liss, Inc.
Multicenter, double‐blind, randomized, intra‐individual crossover comparison of gadobenate dimeglumine and gadopentetate dimeglumine in MRI of brain tumors at 3 tesla
Authors: Rumboldt Zoran , Rowley Howard A. , Steinberg Fred , Maldjian Joseph A. , Ruscalleda Jordi , Gustafsson Lars , Bastianello Stefano 
Published: March 2009

AbstractPurposeTo prospectively compare 0.1 mmol/kg doses of gadobenate dimeglumine and gadopentetate dimeglumine for contrast‐enhanced MRI of brain lesions at 3 Tesla (T).Materials and MethodsForty‐six randomized patients underwent a first examination with gadobenate dimeglumine (n = 23) or gadopentetate dimeglumine (n = 23) and then, after 2–7 days, a second examination with the other agent. Contrast administration (volume, rate), sequence parameters (T1wSE; T1wGRE), and interval between injection and image acquisition were identical for examinations in each patient. Three blinded neuroradiologists evaluated images qualitatively (lesion delineation, lesion enhancement, global preference) and quantitatively (lesion‐to‐brain ratio [LBR], contrast‐to‐noise ratio [CNR], % lesion enhancement). Differences were assessed using Wilcoxon's signed‐rank test. Reader agreement was determined using kappa (κ) statistics.ResultsThere were no demographic differences between groups. The three readers preferred gadobenate dimeglumine globally in 22 (53.7%), 21 (51.2%), and 27 (65.9%) patients, respectively, compared with 0, 1, and 0 patients for gadopentetate dimeglumine. Similar significant (P < 0.001) preference was expressed for lesion border delineation and enhancement. Reader agreement was consistently good (κ = 0.48–0.64). Significantly (P < 0.05) higher LBR (+43.5– 61.2%), CNR (+51.3–147.6%), and % lesion enhancement (+45.9–49.5%) was noted with gadobenate dimeglumine.ConclusionBrain lesion depiction at 3T is significantly improved with 0.1 mmol/kg gadobenate dimeglumine. J. Magn. Reson. Imaging 2009;29:760–767. © 2009 Wiley‐Liss, Inc.
Self‐tracking of contrast kinetics for automatic triggering of contrast‐enhanced whole‐heart coronary magnetic resonance angiography
Authors: Bhat Himanshu , Lai Peng , Li Debiao 
Published: March 2009

AbstractPurposeTo develop a method for automatically triggering centric data acquisition during contrast‐enhanced whole‐heart coronary magnetic resonance angiography (MRA).Materials and MethodsThe hypothesis of this work is that the blood signal changes during contrast infusion can be estimated by obtaining a projection of the heart during inversion‐recovery prepared data acquisition. A validation study was performed on seven healthy volunteers to test this hypothesis. The peak blood signal enhancement detected from the projection was then used to automatically trigger the start of central k‐space data acquisition. Simulations were performed to compare the signal‐to‐noise ratio (SNR) of the proposed self‐triggering method with the fixed delay method. Six healthy volunteers were scanned on a 3T MR system using the proposed self‐triggered method to test its effectiveness on coronary artery visualization.ResultsBased on the validation study, the self‐triggering method provides an accurate representation of the contrast enhancement. Based on the simulations, self‐triggering with centric ordering is expected to give a 27% higher SNR than linear ordering with a fixed imaging delay. Self‐triggering was successfully used in all volunteers and showed excellent depiction of the major coronary arteries.ConclusionThe self‐triggering method can be used to automatically determine the optimal delay time for central k‐space acquisition, for each individual subject, without the need of any extra setup or user interaction. J. Magn. Reson. Imaging 2009;29:809–816. © 2009 Wiley‐Liss, Inc.
Respiratory self‐gating for free‐breathing abdominal phase‐contrast blood flow measurements
Authors: Jin Ning , Lewandowski Robert J. , Omary Reed A. , Larson Andrew C. 
Published: March 2009

AbstractPurposeTo demonstrate the feasibility of using a free‐breathing (FB) respiratory self‐gated (RSG) approach for abdominal phase‐contrast (PC) blood flow measurements.Materials and MethodsPC‐magnetic resonance imaging (MRI) flow measurements were performed within the right renal artery, common hepatic artery, and main portal vein during breath‐hold (BH) and FB with both signal averaging and RSG in eight healthy volunteers. The resultant images were qualitatively scored by two independent reviewers blinded to acquisition techniques. Blood flow volume and cross‐sectional vessel size measurements were compared for three techniques.ResultsThe overall efficiency for the RSG‐PC sequence was 38.9% ± 4.7%. Images acquired with RSG effectively mitigated respiratory motion artifacts, which were clearly evident within FB signal‐averaged images. RSG produced similar image quality to that of BH techniques (P > 0.146) and resulted in similar vessel size measurements (P = 0.694). Flow results for both FB RSG and signal‐averaged reconstructions correlated well with BH flow measurements (r = 0.97 and 0.92, P < 0.001). However, only the RSG methods demonstrated excellent absolute agreement with BH‐PC flow measurements (P = 0.600), with signal‐averaged methods resulting in significant overestimations.ConclusionRSG methods can limit respiratory motion artifacts to reduce flow measurement inaccuracies during free‐breathing PC measurements in the abdomen. J. Magn. Reson. Imaging 2009;29:860–868. © 2009 Wiley‐Liss, Inc.
Quantitative and qualitative comparison of 1.5 and 3.0 tesla MRI in patients with chronic liver diseases
Authors: Ramalho Miguel , Herédia Vasco , Tsurusaki Masakatsu , Altun Ersan , Semelka Richard C. 
Published: March 2009

AbstractPurposeTo compare the quantitative and qualitative image quality intra‐individually, at 1.5 and 3.0 Tesla (T) in patients with chronic liver diseases.Materials and MethodsThe study group included 24 consecutive patients (17 males, 7 females; mean age ± standard deviation 56.5 ± 11.5) who had chronic liver diseases and underwent abdominal MRI for the liver evaluation at both 1.5 and 3.0T within a 4‐month period. All MRI studies were retrospectively evaluated quantitatively and qualitatively. Quantitative analysis was performed by measuring signal to noise ratio (SNR) on various abdominal organs. Qualitative analysis was performed by two reviewers to assess image quality, artifacts, and imaging findings of chronic liver diseases. Quantitative and qualitative analyses findings were compared between 1.5 and 3.0T using the paired Student t‐test and Wilcoxon signed rank test, respectively.ResultsThe statistically significant increase in SNRs in various abdominal tissues ranged from 1.3‐ to 3.5‐fold at 3.0T compared to 1.5T. Three‐dimensional gradient echo (3D‐GE) sequences demonstrated significantly higher image quality at 3.0T (P < 0.01), whereas precontrast spoiled gradient echo (SGE) sequences demonstrated significantly higher image quality at 1.5T (P < 0.01). T2‐weighted sequences did not show any significant difference in image quality between 1.5 and 3.0T (P > 0.05).ConclusionThe SNRs of various abdominal tissues demonstrated significant increases at 3.0T. The image quality of 3D‐GE sequences was higher at 3.0T, whereas the image quality of precontrast SGE sequences was higher at 1.5T. J. Magn. Reson. Imaging 2009;29:869–879. © 2009 Wiley‐Liss, Inc.
Feasibility of quantifying the mechanical properties of lung parenchyma in a small‐animal model using 1H magnetic resonance elastography (MRE)
Authors: McGee Kiaran P. , Hubmayr Rolf D. , Levin David , Ehman Richard L. 
Published: March 2009

AbstractPurposeTo evaluate the feasibility of spatially resolving the shear modulus of lung parenchyma using conventional 1H magnetic resonance elastography (MRE) imaging techniques in a small animal model.Materials and MethodsA 10‐cm diameter transmit‐receive radiofrequency coil was modified to include a specimen stage, an MRE pneumatic drum driver, and needle system. MRE was performed on 10 female Sprague–Dawley rats using a 1H spin‐echo based MRE imaging sequence with a field of view of 7 cm and slice thickness of 5 mm. Air‐filled lungs were imaged at transpulmonary inflation pressures of 5, 10, and 15 cm H2O while fluid‐filled lungs were imaged after infusion of 4 mL of normal saline.ResultsThe average shear modulus of air‐filled lungs was 0.840 ± 0.0524 kPa, 1.07 ± 0.114 kPa and 1.30 ± 0.118 kPa at 5, 10, and 15 cm H2O, respectively. Analysis of variance indicated that these population means were statistically significantly different from one another (F‐value = 26.279, P = 0.00004). The shear modulus of the fluid‐filled lungs was 1.65 ± 0.360 kPa.ConclusionIt is feasible to perform lung MRE in small animals using conventional MR imaging technologies. J. Magn. Reson. Imaging 2009;29:838–845. © 2009 Wiley‐Liss, Inc.
High‐resolution fMRI with higher‐order generalized series imaging and parallel imaging techniques (HGS‐parallel)
Authors: Yun SungDae , Oh Sung Suk , Han Yeji , Park HyunWook 
Published: March 2009

AbstractPurposeTo develop a novel approach for high‐resolution functional MRI (fMRI) using the conventional gradient‐echo sequence.Materials and MethodsEcho‐planar imaging (EPI) techniques have generally been used for fMRI studies due to their fast imaging time. However, it is difficult for studying brain function at the submillimeter level using this sequence. In addition, EPI techniques have some drawbacks, such as Nyquist ghosts and geometric distortions in the reconstructed images, and subsequently require additional postprocessing to reduce these artifacts. One way of solving these problems is to acquire fMRI data by means of a conventional gradient‐echo imaging sequence instead of EPI. To provide a fast imaging time, the proposed method combines higher‐order generalized series (HGS) imaging with a parallel imaging technique which is called the HGS‐parallel technique.ResultsThe proposed HGS‐parallel technique achieves a 12.8‐fold acceleration in imaging time without the cost of spatial resolution. The proposed method was verified through the application of fMRI studies on normal subjects.ConclusionThis study suggests that the proposed method can be used for high‐resolution fMRI studies without the geometric distortion and the Nyquist ghost artifacts compared to EPI. J. Magn. Reson. Imaging 2009;29:924–936. © 2009 Wiley‐Liss, Inc.
Multifocal intravascular papillary endothelial hyperplasia in the retroperitoneum and spine: A case report and review of the literature
Authors: Petry Max , Brown Michele A. , Hesselink John R. , Imbesi Steven G. 
Published: March 2009

AbstractThe authors present a unique case of intravascular papillary endothelial hyperplasia (IPEH) localized in the renal hilum, retroperitoneum, and spine in a patient with Wegener granulomatosis. IPEH rarely occurs in the abdomen or spine with few cases reported in the literature. No case has been reported of IPEH involving both the retroperitoneum and spine. In our case, MR imaging revealed enhancing masses in the right renal hilum and retroperitoneum as well as multiple focal enhancing lesions throughout the spine with lower thoracic ventral thecal sac compression. The diagnosis was established by resection of the renal hilum mass, and interval follow‐up is deemed necessary for the remaining lesions because the long‐term evolution of IPEH with conservative treatment alone is not well established. J. Magn. Reson. Imaging 2009;29:957–961. © 2009 Wiley‐Liss, Inc.
Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease
Authors: Ding Bei , Chen Ke‐Min , Ling Hua‐Wei , Sun Fei , Li Xia , Wan Tao , Chai Wei‐Min , Zhang Huan , Zhan Ying , Guan Yong‐Jing 
Published: March 2009

AbstractPurposeTo investigate the brain iron deposits in patients with Alzheimer's disease (AD) and healthy age‐matched controls using phase imaging.Materials and MethodsTwenty‐six AD patients and 24 healthy controls were recruited. A three‐dimensional high‐resolution, gradient‐echo sequence was used to acquire phase data in the coronal plane. A high‐pass filter was used to remove the phase variation caused by field inhomogeneity. The regions evaluated included the bilateral putamen, globus pallidus, and the head and body of the hippocampus.ResultsSignificantly lower phase values in both the basal ganglion and hippocampus were revealed in the AD group compared to the normal controls (P < 0.05). The phase value in the right side of the head of the hippocampus had a moderate positive correlation with the MMSE score (r= 0.603, P = 0.000) and a negative correlation with the duration of the disease (r = −0.677, P = 0.013). Using −0.0972 radians as an optimal cutoff value, the sensitivity and specificity for differentiation between AD and normal controls reached 95.8 and 80.8%, respectively.ConclusionPhase imaging proved to be a useful method for the differentiation between normal controls and AD patients. An investigation of the excessive accumulation of iron in the hippocampus may help us better understand the pathologic process and neuropsychological dysfunction of AD disease. J. Magn. Reson. Imaging 2009;29:793–798. © 2009 Wiley‐Liss, Inc.
Sequencing of peptide‐derived Amadori products by the electron capture dissociation method
Authors: Stefanowicz Piotr , Kijewska Monika , Szewczuk Zbigniew 
Published: March 2009

AbstractThe electron capture dissociation (ECD) of peptide‐derived Amadori products has been successfully applied for their sequencing. In contrast to the collision induced dissociation (CID), based on the vibrational excitation of peptides, the ECD method does not produce ions formed by fragmentation of the hexose moiety, that facilitates interpretation of the obtained spectra. The fragmentation spectrum is dominated by cn and z·n ions, providing the sufficient information for sequencing of peptides and establishing the location of glycated Lys residues in the peptide chain. The ECD experiments were conducted on a series of synthetic peptides and unseparated digests of glycated ubiquitin. Copyright © 2009 John Wiley & Sons, Ltd.
The unbalanced high‐tech life: are employers liable?
Authors: Kakabadse Nada K. , Porter Gayle , Vance David 
Published: March 2009

Abstract

Technology has created new capabilities, as well as new demands, for many of today's employees. For those who work in technology‐enhanced environments, the pace and round‐the‐clock activity creates a source of stimulation that may become addictive.

While the potential for this type of behavioral addiction is recognized by both researchers and the popular press, few companies are seriously considering the associated risks, one of which could be legal action against the organization.

By combining research on addiction, technology use, workplace demands, and legal precedent, this article considers issues likely to require decision by the courts, as well as background on the evolution of related legal questions for insight to possible outcomes.

Copyright © 2009 John Wiley & Sons, Ltd.