bluuebunny/crossref_metadata_2025_split huggingface dataset:
Routine clinical use of the one‐step nucleic acid amplification assay for detection of sentinel lymph node metastases in breast cancer patients
Authors: Tamaki Yasuhiro , Sato Nobuaki , Homma Keiichi , Takabatake Daisuke , Nishimura Rieko , Tsujimoto Masahiko , Yoshidome Katsuhide , Tsuda Hitoshi , Kinoshita Takayuki , Kato Hironori , Taniyama Kiyomi , Kamio Takako , Nakamura Seigo , Akiyama Futoshi , Noguchi Shinzaburo ,   and the Japanese One‐Step Nucleic Acid Amplification Study Group
Published: January 2012

AbstractBACKGROUND:The objective of this study was to confirm, by means of a multicenter study conducted in Japan, the reliability and usefulness of the one‐step nucleic acid amplification (OSNA) assay in routine clinical use for sentinel lymph node biopsy (SLNB) of breast cancer patients.METHODS:Patients with Tis‐T2N0M0 breast cancer who underwent SLNB before systemic chemotherapy comprised the study cohort. A whole sentinel lymph node (SLN) was examined intraoperatively with the OSNA assay except for a 1‐mm‐thick, central slice of the lymph node, which underwent pathologic examination after the operation. For patients who underwent axillary dissection, non‐SLNs were examined with routine pathologic examination.RESULTS:In total, 417 SLNBs from 413 patients were analyzed. SLN metastases were detected with greater sensitivity by the OSNA assay than by pathologic examination (22.5% vs 15.8%; P < .001), as expected from the difference in size of the specimens examined. Patients who had SLN metastases assessed with the OSNA assay proved to harbor non‐SLN metastases with an overall risk ratio of 33.7%. The risk of non‐SLN metastasis was significantly lower for patients who had positive SLNs assessed as OSNA+ than for those who had SLNs assessed as OSNA++ (17.6% vs 44%; P = .012).CONCLUSIONS:The OSNA assay can be used for routine clinical SLNB, and its assessment for volume of metastasis may be a powerful predictive factor for non‐SLN metastasis. Further studies with more patients are needed to confirm the usefulness of this assay for selection in the clinical setting of patients who do not need axillary dissection. Cancer 2012;3477–3483. © 2012 American Cancer Society.
Limited‐stage diffuse large B‐cell lymphoma treated with abbreviated systemic therapy and consolidation radiotherapy
Authors: Campbell Belinda A. , Connors Joseph M. , Gascoyne Randy D. , Morris W. James , Pickles Tom , Sehn Laurie H. 
Published: January 2012

AbstractBACKGROUND:For limited‐stage diffuse large B‐cell lymphoma (DLBCL), treatment decisions are often influenced by toxicity profiles. One strategy that minimizes chemotherapy‐induced toxicities is abbreviated chemotherapy plus consolidation involved‐field radiotherapy (IFRT). Involved‐node radiotherapy (INRT) is a new concept to DLBCL, aimed to reduce radiotherapy‐induced toxicities. We retrospectively review the long‐term outcomes of limited‐stage DLBCL treated with abbreviated systemic therapy and radiotherapy focusing on field size: IFRT versus INRT.METHODS:The British Columbia Cancer Agency Lymphoid Cancer Database was used to identify patients diagnosed with limited‐stage DLBCL (stage I/II, without B‐symptoms; bulk < 10 cm) from 1981 to 2007. Patients were prescribed 3 cycles of chemotherapy plus IFRT (1981‐1996) or INRT≤5 cm (1996‐2007), defined as INRT to the prechemotherapy involved nodes with margins ≤ 5 cm.RESULTS:A total of 288 patients were identified: 56% were aged >60 years, 34% had stage II disease, 55% had extranodal disease, 19% had elevated lactate dehydrogenase levels, and 15% received rituximab. The two radiotherapy groups were IFRT (138 patients; 48%) and INRT≤5cm (150 patients; 52%); median follow‐up was 117 and 89 months, respectively. Distant relapse was the most common site of failure in both groups. After INRT≤5 cm, marginal recurrence was infrequent (2%). Time to progression (P = .823), progression‐free survival (P = .575), and overall survival (P = .417) were not significantly different between the radiotherapy cohorts. Radiotherapy field size was not a significant prognostic factor on multivariate analyses.CONCLUSIONS:This research is the first known body of work to apply the concept of INRT to limited‐stage DLBCL. Reducing the field size from IFRT to INRT≤5 cm maintains a low marginal recurrence risk with no impact on overall outcome. Cancer 2012. © 2012 American Cancer Society.
Gene expression identifies heterogeneity of metastatic propensity in high‐grade soft tissue sarcomas
Authors: Skubitz Keith M. , Francis Princy , Skubitz Amy P. N. , Luo Xianghua , Nilbert Mef 
Published: January 2012

AbstractBACKGROUND:Metastatic propensity of soft tissue sarcoma (STS) is heterogeneous and may be determined by gene expression patterns that do not correlate well with morphology. The authors have reported gene expression patterns that distinguish 2 broad classes of clear cell renal carcinoma (ccRCC‐gene set), and other patterns that can distinguish heterogeneity of serous ovarian carcinoma (OVCA‐gene set) and aggressive fibromatosis (AF‐gene set); however, clinical follow‐up data were not available for these samples.METHODS:In the current study, gene expression patterns in 73 samples of high‐grade STS were examined using spotted cDNA microarray slides that contained ∼16,000 unique UniGene clusters. Approximately 50% of the genes present in the ccRCC‐, OVCA‐, and AF‐gene sets were also represented in the data from this chip set, and these were combined to form a composite gene set of 278 probes.RESULTS:Hierarchical clustering using this composite gene set suggested the existence of subsets of the STS samples. Analysis revealed differences in the time to development of metastatic disease between the clusters defined by the first branch point of the clustering dendrogram (P = .005), and also among the 4 different clusters defined by the second branch points (P = .001).CONCLUSIONS:This approach suggests the existence of >2 subsets of high‐grade pleomorphic STS, each with distinct clinical behavior. A composite gene set such as that described here may be useful to stratify STS in clinical trials, and may be of practical utility in patient management. Cancer 2012. © 2012 American Cancer Society.
Associations among physical activity, body mass index, and health‐related quality of life by race/ethnicity in a diverse sample of breast cancer survivors
Authors: Paxton Raheem J. , Phillips Karon L. , Jones Lovell A. , Chang Shine , Taylor Wendell C. , Courneya Kerry S. , Pierce John P. 
Published: January 2012

AbstractBACKGROUND:Health‐related quality of life (HRQOL), body mass index (BMI), and physical activity (PA) levels have all been associated with prognosis following breast cancer and may explain partially the higher mortality for breast cancer in certain racial/ethnic subgroups. In this study, associations between PA, BMI, and HRQOL by race were examined in a sample of breast cancer survivors.METHODS:Measures of PA, BMI, and HRQOL as well as demographic and medical characteristics of women (N = 3013, 13% nonwhite) who participated in the Women's Healthy Eating and Living Study were assessed at baseline. Analysis of covariance was used to examine the relationship between PA and obesity with HRQOL outcomes. Statistical tests were 2‐sided.RESULTS:African American women were less likely to meet guidelines for PA and more likely to be obese than women from other ethnic groups (P < .05). In adjusted models, women who met guidelines for PA reported significantly higher physical health composite (point differences ranged from 10.5 to 21.2 points, all P < .05) and vitality (point differences ranged from 9.9 to 16.5 points, all P < .05) scores than those who did not, regardless of race/ethnicity. Associations between obesity and HRQOL were mixed with fewer associations for Asian American and African American women and stronger associations for whites.CONCLUSIONS:Breast cancer survivors from racially and ethnically diverse populations have lower levels of PA and higher rates of obesity that are generally associated with poorer HRQOL. Culturally sensitive PA and weight loss interventions may improve these lifestyle characteristics and result in improved HRQOL. Cancer 2012. © 2012 American Cancer Society.
Outcome after ipsilateral breast tumor recurrence in patients who receive accelerated partial breast irradiation
Authors: Shah Chirag , Vicini Frank , Keisch Martin , Kuerer Henry , Beitsch Peter , Haffty Bruce , Lyden Maureen 
Published: January 2012

AbstractBACKGROUND:The objective of this study was to examine clinical outcomes and patterns of failure in patients with early stage breast cancer who developed an ipsilateral breast tumor recurrence (IBTR) after breast‐conserving therapy (BCT) using accelerated partial breast irradiation (APBI).METHODS:In total, 1440 patients (1449 tumors) with early stage breast cancer who underwent BCT were treated with the MammoSite device to deliver APBI (34 Gray [Gy] in 3.4‐Gy fractions). One thousand two hundred fifty‐five patients (87%) had invasive breast cancer (IBC) (median tumor size, 10 mm), and 194 patients (13%) had ductal carcinoma in situ (DCIS) (median tumor size, 8 mm). The median follow‐up was 60 months.RESULTS:Fifty patients (3.5%) developed an IBTR for a 5‐year actuarial rate of 3.61% (3.65% for IBC and 3.36% for DCIS). It was determined that 36 recurrences (72%) represented new primary cancers, and 14 recurrences (28%) represented recurrences of the index lesion. Of the 32 recurrences with known histology, 78% were IBC, and 22% were DCIS. After IBTR, 28 of 38 patients (74%) underwent salvage mastectomy, and 9 of 38 patients (26%) had a second attempt at BCT. Adjuvant therapies included tamoxifen in 8 patients (16%) and systemic chemotherapy in 6 patients (12%). The 3‐year rates of disease‐free survival, cause‐specific survival, and overall survival after IBTR were 58.7%, 92.1%, and 80.5%, respectively.CONCLUSIONS:With 5 years of follow‐up, APBI produced clinical outcomes and patterns of failure comparable to those achieved with whole breast irradiation. Patients who developed an IBTR after APBI had excellent 3‐year survival outcomes after salvage treatments. Cancer 2012. © 2012 American Cancer Society.
Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer
Authors: Kapadia Nirav S. , Mamet Rizvan , Zornosa Carrie , Niland Joyce C. , D'Amico Thomas A. , Hayman James A. 
Published: January 2012

AbstractBACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period.METHODS:Treatment characteristics of patients with incurable NSCLC who received RT at the EOL, defined as within 14 days of death, were analyzed from the National Comprehensive Cancer Network NSCLC Outcomes Database.RESULTS:Among 1098 patients who died, 10% had received EOL RT. Patients who did and did not receive EOL RT were similar in terms of sex, race, comorbid disease, and Eastern Cooperative Oncology Group performance status. On multivariable logistic regression analysis, independent predictors of receiving EOL RT included stage IV disease (odds ratio [OR], 2.04; 95% confidence interval [CI], 1.09‐3.83) or multiorgan involvement (OR, 1.75; 95% CI, 1.08‐2.84) at diagnosis, age <65 years at diagnosis (OR, 1.85; 95% CI, 1.21‐2.83), and treating institution (OR, 1.24‐5.94; P = .02). Nearly 50% of EOL RT recipients did not complete it, most commonly because of death or patient preference.CONCLUSIONS:In general, EOL RT was received infrequently, was delivered more commonly to younger patients with more advanced disease, and often was not completed as planned. There also was considerable variation in its use among National Comprehensive Cancer Network institutions. Next steps include expanding this research to other cancers and settings and investigating the clinical benefit of such treatment. Cancer 2012. © 2012 American Cancer Society.
Computational model of soft tissues in the human upper airway
Authors: Pelteret J‐P. V. , Reddy B. D. 
Published: January 2012

SUMMARYThis paper presents a three‐dimensional finite element model of the tongue and surrounding soft tissues with potential application to the study of sleep apnoea and of linguistics and speech therapy. The anatomical data was obtained from the Visible Human Project, and the underlying histological data was also extracted and incorporated into the model. Hyperelastic constitutive models were used to describe the material behaviour, and material incompressibility was accounted for. An active Hill three‐element muscle model was used to represent the muscular tissue of the tongue. The neural stimulus for each muscle group was determined through the use of a genetic algorithm‐based neural control model. The fundamental behaviour of the tongue under gravitational and breathing‐induced loading is investigated. It is demonstrated that, when a time‐dependent loading is applied to the tongue, the neural model is able to control the position of the tongue and produce a physiologically realistic response for the genioglossus. Copyright © 2012 John Wiley & Sons, Ltd.
Human skull shape and masticatory induced stress: Objective comparison through the use of non‐rigid registration
Authors: Jansen van Rensburg Gerhardus J. , Wilke Daniel N. , Kok Schalk 
Published: January 2012

SUMMARYVariation in masticatory induced stress, caused by shape changes in the human skull, is quantified in this article. A comparison on masticatory induced stress is presented subject to a variation in human skull shape. Non‐rigid registration is employed to obtain appropriate computational domain representations. This procedure allows the isolation of shape from other variations that could affect the results. An added benefit, revealed through the use of non‐rigid registration to acquire appropriate domain representation, is the possibility of direct and objective comparison and manipulation. The effect of mapping uncertainty on the direct comparison is also quantified. As shown in this study, exact difference values are not necessarily obtained, but a non‐rigid map between subject shapes and numerical results gives an objective indication on the location of differences. Copyright © 2012 John Wiley & Sons, Ltd.
UPCBLAS: a library for parallel matrix computations in Unified Parallel C
Authors: González‐Domínguez Jorge , Martín María J. , Taboada Guillermo L. , Touriño Juan , Doallo Ramón , Mallón Damián A. , Wibecan Brian 
Published: January 2012

SUMMARYThe popularity of Partitioned Global Address Space (PGAS) languages has increased during the last years thanks to their high programmability and performance through an efficient exploitation of data locality, especially on hierarchical architectures such as multicore clusters. This paper describes UPCBLAS, a parallel numerical library for dense matrix computations using the PGAS Unified Parallel C language. The routines developed in UPCBLAS are built on top of sequential basic linear algebra subprograms functions and exploit the particularities of the PGAS paradigm, taking into account data locality in order to achieve a good performance. Furthermore, the routines implement other optimization techniques, several of them by automatically taking into account the hardware characteristics of the underlying systems on which they are executed. The library has been experimentally evaluated on a multicore supercomputer and compared with a message‐passing‐based parallel numerical library, demonstrating good scalability and efficiency. Copyright © 2012 John Wiley & Sons, Ltd.
Palladium Nanoparticles Supported on Mixed‐Linker Metal–Organic Frameworks as Highly Active Catalysts for Heck Reactions
Authors: Huang Yuanbiao , Gao Shuiying , Liu Tianfu , Lü Jian , Lin Xi , Li Hongfang , Cao Rong 
Published: January 2012

AbstractWell‐dispersed palladium nanoparticles (Pd NPs) supported on amine‐functionalized, mixed‐linker metal–organic frameworks (MIXMOFs) based on MIL‐53(Al) were prepared by using the ion‐exchange method. Pd NPs were characterized by powder X‐ray diffraction (XRD), N2 adsorption, transmission electron microscopy (TEM), inductively coupled plasma atomic emission spectroscopy (ICP‐AES), and X‐ray photoelectron spectroscopy (XPS). The mean diameter of Pd NPs is approximately 3.2 nm. It was found that the Pd NPs supported on amine‐functionalized MIXMOFs are stable at high temperature. The Pd NPs exhibit efficient catalytic activity for Heck reaction and can be easily recovered and reused.
Chiral Ammonium‐Capped Rhodium(0) Nanocatalysts: Synthesis, Characterization, and Advances in Asymmetric Hydrogenation in Neat Water
Authors: Guyonnet Bilé Elodie , Cortelazzo‐Polisini Elodie , Denicourt‐Nowicki Audrey , Sassine Rita , Launay Franck , Roucoux Alain 
Published: January 2012

AbstractOptically active amphiphilic compounds derived from N‐methylephedrine, N‐methylprolinol, or cinchona derivatives possessing bromide or chiral lactate counterions were efficiently used as protective agents for rhodium(0) nanoparticles. The full characterization of these surfactants and the obtained nanocatalysts was performed by means of different techniques. These spherical nanoparticles, with sizes between 0.8–2.5 nm depending on the stabilizer, were evaluated in the hydrogenation of model substrates in neat water as a green solvent. The rhodium catalysts showed relevant kinetic properties, but modest enantiomeric excess values of up to 13 % in the hydrogenation of ethyl pyruvate. They were also investigated in the hydrogenation of disubstituted arenes, such as m‐methylanisole, providing interesting catalytic activities and a preferential cis selectivity of around 80 %; however, no asymmetric induction was observed.
The unconditioned stimulus pre‐exposure effect in preweanling rats in taste aversion learning: Role of the training context and injection cues
Authors: Revillo D.A. , Arias C. , Spear N.E. 
Published: January 2012

AbstractThe unconditioned stimulus pre‐exposure effect (US‐PE) refers to the interference paradigm in which acquisition of the conditioned response is retarded due to prior experience with the US. Most studies analyzing the psychological mechanisms underlying this effect have been conducted with adult rats. The most widely accepted hypothesis explains this effect as a contextual blocking effect. Contextual cues associated with the US block the conditioned stimulus (CS)‐US association during conditioning. The modulatory role of a context devoid of distinctive olfactory attributes is not observable until approximately PD23 in rats, including modulation of interference paradigms such as latent inhibition or extinction. In this study, we analyzed US‐PE in preweanling rats along with the role of the training context in this effect in terms of conditioned taste aversion preparation. Pre‐exposure to LiCl before conditioning retarded the acquisition of taste aversion. The US‐PE was observed in preweanling rats when, during pre‐exposure, subjects were exposed to the conditioning context, and this effect was not attenuated either by the administration of the US in a familiar environment (Experiment 1a), or by the presence of an alternative, more salient context during pre‐exposure (Experiment 1b). Additionally, the US‐PE was still observed when the route by which the US was administered was changed between the pre‐exposure and conditioning phases (Experiment 2a) as well as when the injection cues were removed during conditioning (Experiment 2b). These experiments show a strong US‐PE in preweanling rats and fail to support the contextual blocking hypothesis, at least in this stage of ontogeny. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 55: 193–204, 2013
Crank‐shaped and Y‐shaped through‐hole interconnections filled with Au‐Sn solder
Authors: Yamamoto Satoshi , Nukaga Osamu , Wakioka Hiroyuki , Suemasu Tatsuo , Hashimoto Hirokazu 
Published: January 2012

AbstractCrank‐shaped and Y‐shaped through‐hole interconnections (THI) filled with Au‐Sn solder are demonstrated in this study. They are expected to realize a higher‐density wafer‐level package (WLP) for electrical devices including the fields of MEMS (Micro Electro‐Mechanical Systems) and MOEMS (Micro Optical Electro‐Mechanical Systems) compared with conventional WLP using THI consisting of straight through‐holes. In this paper, formation techniques for crank‐shaped and Y‐shaped THI are described. In order to make crank‐shaped and Y‐shaped through‐holes in a substrate, both femtosecond laser irradiation and wet chemical etching are used. Crank‐shaped through‐holes with an 80‐μm opening and 400 μm deep have also been achieved. Gold (Au)‐tin (Sn) solder was filled into the holes using the molten metal suction method (MMSM). Airtightness of the THI was examined using the helium leakage test, and the estimated leakage rate was less than 1.0 × 10−9 Pa·m3/s, which is sufficient for use in WLP applications. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 179(1): 54–62, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21134
Diagnosis of periodontal diseases by biomarkers
Authors: Kido Jun‐Ichi , Hino Mami , Bando Mika , Hiroshima Yuka 
Published: January 2012

AbstractMany middle‐aged and elderly people suffer from periodontal diseases that mainly cause tooth loss and result in some systemic diseases. The prevention of periodontal diseases is very important for oral and systemic health, but the present diagnostic examination is not fully objective or suitable. To diagnose periodontal diseases exactly, some biomarkers that represent inflammation, tissue degradation, and bone resorption in gingival crevicular fluid (GCF) and saliva are known. We demonstrated that the GCF levels of calprotectin, an inflammation‐related protein, and carboxy‐terminal propeptide of type I procollagen, a bone metabolism‐related protein, were associated with the clinical condition of periodontal diseases, and suggested that these proteins might be useful biomarkers for periodontal diseases. Recently, determinations of genes and proteins by using microdevices have been studied for the diagnosis of some diseases. We detected calprotectin protein by chemiluminescent immunoassay on a microchip and showed the possibility of specific and quantitative detection of calprotectin in a very small amount of GCF. The determination of multiple markers in GCF by using microdevices will contribute to the development of accurate and objective diagnostic systems for periodontal diseases. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 179(1): 40–45, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21150
A study of centralized voltage profile control of distribution network considering dynamics of distributed generator
Authors: Tsuji Takao , Tomura Kohsuke , Oyama Tsutomu , Hashiguchi Takuhei , Goda Tadahiro , Tange Seiji , Nomura Toshio 
Published: January 2012

AbstractIn a future distribution network, it will be difficult to maintain system voltage because a large number of distributed generators are introduced into the system. The authors have previously proposed a voltage profile control method using power factor control of distributed generators. When all information on the system is available, an ideal stationary solution of control orders to distributed generators is given by an optimization calculation. However, it is difficult to apply optimization control in real time because a long calculation time is required for the optimization. Therefore, it is possible that a voltage change may occur before the power factor control has finished. Thus, in this paper, we develop a new control method which can save the excessive voltage changes by taking into consideration the controlled response time of distributed generators. The proposed method was tested in a 24‐node distribution network model. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 179(1): 29–39, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21231