bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of the Russian population of patients with coronary artery disease or peripheral artery disease in the XATOA registry
Authors: Arakelyan V. S. , Erlikh A. D. , Amirov N. Sh. , Dubar E. , Vogtlaender K. , Debus S. 
Published: June 2024

Aim. To analyze demographic, anamnestic and clinical parameters in subjects with coronary artery disease (CAD) or peripheral artery disease (PAD) included in the XATOA study from Russian centers and to compare them with the total population of the international registry.Material and methods. XATOA study is an international, multicenter, prospective registry, where characteristics of patients receiving dual pathway inhibition therapy with rivaroxaban 2,5 mg twice a day and low-dose acetylsalicylic acid (ASA) daily were analyzed. The secondary endpoint of the study was to assess clinical outcomes and bleeding rates in real world setting.This analysis was based on the comparison of indicators presented in tables of descriptive statistics from the XATOA study database for subjects from Russia and the general study database respectively. The methodology of this sub-analysis is descriptive only and does not imply any statistical difference assessment.Results. The Russian population included 795 subjects: 232 (29.2%) subjects with CAD; 293 (36.9%) subjects with PAD and 270 (34.0%) subjects with both. The average follow-up period was 14.4 months. The most common antithrombotic treatment regimen for patients with CAD or PAD prior enrollment in the registry was ASA monotherapy (81.3%); ACE inhibitors/ARBs were prescribed in 61.8%, lipid-l owering therapy in 68.9%. After the enrollment and prescription of rivaroxaban 2.5 mg BID + ASA, the incidence of myocardial infarction, stroke or cardio-v ascular death in subjects in the Russian Federation remained at 1.9%, and the incidence of major adverse limb events (MALE) at 0.8%, which corresponds to the results obtained in the COMPASS randomized controlled trial. Major bleeding was reported in 1 subject (<0.1%). Adherence to the therapy among subjects in the Russian Federation amounted to 89.8%.Conclusion. Despite the increased incidence of concomitant diseases and insufficient use of routine cardiovascular therapy in subjects with CAD or PAD in the Russian Federation, the ischemic complications rate remains at a relatively low level while using antithrombotic treatment with rivaroxaban 2.5 mg twice a day + ASA 100 mg a day.
Pengembangan E-Modul Interaktif pada Materi Gelombang Bunyi Berbasis Problem Based Learning
Authors: Fitri Upik Rahma , Sunaryo  , Khairun Nisa Salsabila , Ziveria Mira 
Published: June 2024

This study aims to develop an interactive e-module based on problem-based learning for teaching physics, specifically focusing on sound waves. The research method employed is Research and Development (R&D) utilizing a modified 4D development model, consisting of three stages: Define, Design, and Develop. This e-module is equipped with text, images, videos, animations, and interactive features such as quizzes, exercises, and navigation to facilitate user interaction with the learning materials. The problem-based learning model is applied to focus learning on problem-solving. Needs analysis conducted with 40 eleventh-grade students revealed that 60 percent chose sound waves as the preferred topic, hence it was selected as the research focus. Small and large-scale trials showed increased average scores, and students' response to this e-module was excellent. Validation by four experts yielded an average percentage of 91.5 percent, indicating that this problem-based learning interactive e-module is appropriate for use as a physics learning tool.

Abstrak
Penelitian ini bertujuan untuk mengembangkan e-modul interaktif berbasis problem-based learning pada materi gelombang bunyi yang layak digunakan dalam pembelajaran fisika. Metode penelitian yang digunakan adalah Research and Development (R&D) dengan model pengembangan 4D yang dimodifikasi menjadi tiga tahapan: Define (Pendefinisian), Design (Perancangan), dan Develop (Pengembangan). E-modul ini dilengkapi dengan teks, gambar, video, animasi, serta fitur interaktif seperti kuis, latihan soal, dan navigasi untuk memudahkan interaksi pengguna dengan materi pembelajaran. Model pembelajaran problem-based learning diterapkan untuk memfokuskan pembelajaran pada pemecahan masalah. Analisis kebutuhan dilakukan terhadap 40 peserta didik kelas XI, menunjukkan bahwa 60 persen memilih materi gelombang bunyi, sehingga dipilih sebagai fokus penelitian. Uji coba skala kecil dan skala besar menunjukkan peningkatan skor rata-rata, dan respon peserta didik terhadap e-modul ini adalah sangat baik. Validasi oleh empat ahli memberikan persentase rata-rata sebesar 91,5 persen, yang mengindikasikan bahwa e-modul interaktif berbasis problem-based learning ini layak digunakan sebagai media pembelajaran fisika.
A novel approach for dose distribution comparison based on image registration principle
Authors: Bellahsaouia Meryeme , Zidouh Ibtissam , Chfeq Wafae , Belhaj Omaima Essaad , Elaarabi Deiaa , Boukhal Hamid , Elkhoukhi Taher , Chakir Elmahjoub 
Published: June 2024

Abstract

Introduction:
Radiotherapy relies on accurate dose distribution comparison methods, but current approaches have limitations. This study introduces a novel algorithm based on image registration principles to address these limitations.
Materials & methods
The algorithm transforms an evaluated dose distribution into the coordinates of a reference dose distribution using an estimated transformation matrix. This matrix is obtained through a series of image registration steps, including detecting keypoints, constructing descriptors, matching keypoints, and estimating an affine transformation matrix. The resulting evaluated distribution has the same size as the reference, allowing for direct comparison using linear least squares regression.
Results
The algorithm was validated using 175 dose distribution pairs, showing its efficacy for distributions differing by a factor of 2 or less, with acceptable bias and precision. However, accuracy decreased for distributions with smooth dose contours lacking convexity defects (distinct features).
Conclusions
The algorithm validation yielded acceptable outcomes, supporting the potential use of this method in clinical practice. Nevertheless, further research is needed to improve its performance for smooth dose distributions.
Metacognition during fake news detection induces an ineffective demand for disambiguating information
Authors: Dreher Jean-Claude , Guigon Valentin , Villeval Marie Claire 
Published: June 2024

Abstract

The mechanisms by which individuals evaluate the veracity of uncertain news and subsequently decide whether to seek additional information to resolve uncertainty remain unclear. In a controlled experiment participants assessed non-partisan ambiguous news and made decisions about whether to acquire extra information. Interestingly, confidence in their judgments of news veracity did not reliably predict actual accuracy, indicating limited metacognitive ability in navigating ambiguous news. Nonetheless, the level of confidence, although uncalibrated, was the primary driver of the demand for additional information about the news, with lower confidence driving a greater demand, regardless of its veracity judgment. This demand for disambiguating information, driven by the uncalibrated metacognition, was increasingly ineffective as individuals became more enticed by the ambiguity of the news. Our findings highlight how metacognitive abilities shape decisions to seek or avoid additional information amidst ambiguity, suggesting that interventions targeting ambiguity and enhancing confidence calibration could effectively combat misinformation. Main Text
Implementation of a parent training intervention (SPARCK) to prevent childhood mental health problems: study protocol for a pragmatic implementation trial in Norwegian municipalities
Authors: Grønlie Anette Arnesen , Backer-Grøndahl Agathe , Nes Ragnhild Bang , Gomez Maria Begoña , Tømmerås Truls 
Published: June 2024

Abstract

Background: Effective evidence-based interventions (EBI) are necessary to prevent and avoid negative life trajectories for children with mental health problems. Even though many EBIs prove effective when tested, few are successfully implemented and used in real world clinical practice. As a result, many children and families do not receive the best care in due time or at all. To reduce this research-practice gap, a combined RCT and implementation study of Supportive Parents – Coping Kids (SPARCK), a parent training intervention to prevent childhood mental health problems will be performed. This study protocol concerns the implementation part of the larger effectiveness-implementation project.
Methods: The study is a correlational multi-site implementation study of SPARCK performed alongside a two-armed RCT, in 24 Norwegian municipalities. A quantitative three-wave longitudinal web-based data collection will be conducted among SPARCK practitioners and leaders in relevant services.
We will investigate the relations between theory-driven and empirical implementation determinants and implementation outcomes, measured by fidelity, acceptability, appropriateness, and feasibility. In addition, we will examine how these implementation determinants and outcomes are associated with the clinical outcomes of SPARCK.
Discussion: The current study will investigate implementation determinants and their relation to indicators of implementation success, while simultaneously investigating effectiveness of an intervention optimized to the needs of both the target group and relevant stakeholders. Together, this may improve clinical effect, contextual fit, implementation success, and reduce the time lag between research findings and application in real-world settings.
Trial registration: ClinicalTrials.gov ID: NTCT05800522
Mott resistive switching initiated by topological defects
Authors: Giannetti Claudio , Milloch Alessandra , Figueruelo-Campanero Ignacio , Hsu Wei-Fan , Mor Selene , Mellaerts Simon , Maccherozzi Francesco , Veiga Larissa Ishibe , Dhesi Sarnjeet , Spera Mauro , Seo Jin , Locquet Jean-Pierre , Fabrizio Michele , Menghini Mariela 
Published: June 2024

Abstract

Avalanche resistive switching is the fundamental process that triggers the sudden change of the electrical properties in solid-state devices under the action of intense electric fields[1]. Despite its relevance for information processing, ultrafast electronics, neuromorphic devices, resistive memories and brain-inspired computation[1-14], the nature of the local stochastic fluctuations that drive the formation of metallic regions within the insulating state has remained hidden.
Here, using operando X-ray nano-imaging, we have captured the origin of resistive switching in a V2O3-based device under working conditions. V2O3 is a paradigmatic Mott material[3], which undergoes a first-order metal-to-insulator phase transition together with a lattice transformation that breaks the threefold rotational symmetry of the rhombohedral metallic phase[2,5,6,8-11,15]. We reveal a new class of volatile electronic switching triggered by nanoscale topological defects appearing in the shear-strain based order parameter that describes the insulating phase. Our results pave the way to the use of strain engineering approaches to manipulate such topological defects and achieve the full dynamical control of the electronic Mott switching. Topology-driven, reversible electronic transitions are relevant across a broad range of quantum materials, comprising transition metal oxides, chalcogenides and kagome metals.
Effect of the cervical and thoracic "Daoyin" training on posture and pulmonary function in patients with upper crossed syndrome: A randomized controlled trial
Authors: Guo Yue , Li Ming , Xie Chaowei , Liu Xiaoyan , Chen Yushan , Yang Jun , Wu Yuxue , Chen Shaoqing , Wang Shizhong , Lin Jianping 
Published: June 2024

Abstract

Background: With the growing ubiquity of electronic devices, the incidence of upper crossed syndrome (UCS) is increasing every year and tends to affect younger populations. The study designed to assess the effect of cervical and thoracic "Daoyin" training on pain, posture, pulmonary function, cervical range of motion, and emotional state in college students with UCS.
Methods: We conducted a parallel-group randomized control study, assigning 74 college students to intervention group (IG) and control group (CG) at Fujian Medical University, Fujian, China. Instructed cervical and thoracic "Daoyin" training was given to students in the IG for eight weeks, five days a week for 45 minutes, whereas students in the CG continued with their usual activities. Primary outcomes, including forward head and shoulder angles, pain and cervical spine function, as well as secondary outcomes, such as pulmonary function, cervical range of motion and emotional state were measured at baseline and at a follow-up of eight weeks. These measurements were conducted using photogrammetry, visual analog scale(VAS), Neck Disability Index(NDI), pulmonary function, cervical range of motion test and Self-rating Anxiety Scale, respectively. We analyzed the effect of cervical and thoracic "Daoyin" training on college students with UCS using a general linear model.
Results: Analyses using general linear model revealed that the IG had a obvious improvement in the forward head angle, forward shoulder angle, and emotional state compared with the CG from baseline to eight weeks post-intervention (F=11.415, P<0.001; F=5.490, P=0.020; F=4.411, P=0.037). In addition, there were significant improvements in VAS (d=0.854, P<0.001), NDI (d=0.754, P=0.005), pulmonary function (forced vital capacity (FVC) (d=0.531, P=0.025), forced expiratory volume in 1 second (FEV1) (d=0.521, P=0.028), FEV1/FVC (d=0.540, P=0.034), maximal voluntary ventilation (MVV) (d=0.888, P<0.001) and cervical range of motion in forward flexion (FF) (d=0.353, P=0.029) at the end of 8-week intervention in IG. No side-effects were observed in this study.
Conclusion: Cervical and thoracic “Daoyin” training can improve the pain, posture, cervical spine function, pulmonary function, cervical range of motion in forward flexion , and emotional state of college students with UCS to some extent.
Trial registration: ChiCTR2300072669 (20/06/2023), Prospective registration, www.chictr.org.cn
Prevalence and factors associated with fatigue in patients with psoriatic arthritis: a systematic review and meta-analysis
Authors: Tang Haoming , Chew Tricia Li Ting , Fong Warren 
Published: June 2024

Abstract

Objectives: Fatigue is a prominent symptom in patients with psoriatic arthritis (PsA). There was a wide variety of statistics previously reported on fatigue prevalence in patients. This systematic review examined the current literature to derive the overall prevalence of fatigue and risk factors in PsA patients.
Methods:
A systematic review of the literature with subsequent meta-analyses was conducted. Publications assessing fatigue severity and prevalence in patients with PsA using validated measurement scores were identified from seven online databases (Cochrane, CINAHL, EMBASE, Google Scholar, MEDLINE, PubMed, and Web of Science), from inception until April 2023. Employing a random effects model, we calculated the pooled fatigue prevalence. Quality assessment of included studies was performed utilising the Joanna Briggs Critical Appraisal Tool.
Results:
The final analysis included 15 studies with 6482 PsA patients. Pooled fatigue prevalence was 0.51 (95% CI: 0.41, 0.61; I2 = 97.4%). There was substantial heterogenicity across the studies, with biologics use and geographical location in terms of Western versus Eastern countries being possible sources of heterogeneity. Age, disease duration, gender, tender joint count, swollen joint and enthesitis count are among the most commonly reported risk factors for fatigue in multivariate logistic regressions.
Conclusions:
Approximately half of the patients with PsA experienced fatigue. Biologics use and geographical location of the study were possible sources of heterogeneity in the subgroup analysis.
Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma
Authors: Faber Anthony , Floors Konstantinos , Fairchild Carter , Li Jinxiu , Zhang Kun , Roberts Jane , Kurupi Richard , Hu Bin , Kraskauskiene Vita , Hosseini Nayyerehalsadat , Shen Shanwei , Inge Melissa , Smith-Fry Kyllie , Li Li , Sotiriou Afroditi , Dalton Krista , Jose Asha , Abdelfadiel Elsamani , Xing Yanli , Hill Ronald , Slaughter Jamie , Shende Mayuri , Lorenz Madelyn , Hinojosa Mandy , Belvin Benjamin , Lai Zhao , Books sosipatros , Stamatouli Angeliki , Lewis Janina , Manjili Masoud , Valerie Kristoffer , Li Renfeng , Banito Ana , Poklepovic Andrew , Koblinski Jennifer , Siggers Trevor , Dozmorov Mikhail , Jones Kevin , Radhakrishnan Senthil 
Published: June 2024

Abstract

Synovial Sarcoma (SS) is driven by the SS18::SSX fusion oncoprotein and is ultimately refractory to therapeutic approaches. SS18::SSX alters ATP-dependent chromatin remodeling BAF (mammalian SWI/SNF) complexes, leading to the degradation of canonical (cBAF) complex and amplified presence of an SS18::SSX-containing non-canonical BAF (ncBAF or GBAF) that drives an SS-specific transcription program and tumorigenesis. We demonstrate that SS18::SSX activates the SUMOylation program and SSs are sensitive to the small molecule SAE1/2 inhibitor, TAK-981. Mechanistically, TAK-981 de-SUMOylates the cBAF subunit SMARCE1, stabilizing and restoring cBAF on chromatin, shifting away from SS18::SSX-ncBAF-driven transcription, associated with DNA damage and cell death and resulting in tumor inhibition across both human and mouse SS tumor models. TAK-981 synergized with cytotoxic chemotherapy through increased DNA damage, leading to tumor regression. Targeting the SUMOylation pathway in SS restores cBAF complexes and blocks the SS18::SSX-ncBAF transcriptome, identifying a therapeutic vulnerability in SS, positioning the in-clinic TAK-981 to treat SS.
Different species of Tillandsia can be biomonitors of carbon and nitrogen emissions: the case of a tropical metropolitan area in Mexico
Authors: Tirado Paula Zamora , Perroni Yareni , Álvarez Edison Armando Diaz 
Published: June 2024

Abstract

Air pollution affects human health and ecosystems all over the world. However, little attention is paid to its monitoring in tropics, mainly due to the high costs of automated monitoring systems. Biomonitoring may be an alternative, particularly for species of Tillandsia genus, although most species are not yet calibrated for this purpose. Therefore, 1) to determine the biomonitoring potential of T. juncea and T. schiedeana and, 2) to compare the sources and magnitudes of atmospheric pollutants at five urban parks and one rural site in a tropical metropolitan area in Mexico, we measured the elemental and isotopic composition of carbon (C) and nitrogen (N) of four Tillandsia species. The C content averaged 44.6 ± 0.5% (dry weight; p > 0.05). The N content ranged from 0.6 ± 0.1% for the rural site and 2.0 ± 0.1% for an urban site (p < 0.001). The lowest value of δ13C was − 15.9 ± 0.1‰ for T. usneoides for all urban parks, and the highest was − 14.3 ± 0.2‰ for T. juncea in the rural area (p < 0.001). The lowest δ15N of − 12.1 ± 0.2‰ was recorded for T. usneoides in the rural area, and the highest of − 0.5 ± 0.5‰ were recorded for T. schiedeana in one of the urban sites. The four species can be used as biomonitors of C and N emissions, since their specific variations reflect the source and concentration of these atmospheric pollutants. Furthermore, the tillandsias showed that pollution in the metropolitan area is different depending on the activity at each site.
Controlling mechanism of shale palaeoenvironment on its resistivity and polarizability: A case study of the Longmaxi Formation in Southern Sichuan
Authors: Yang Kai , Zhang Bing , Wang Xuben , Cao Gaoquan 
Published: June 2024

Abstract

The mineral composition, content, and organic matter enrichment in shale are significantly influenced by the sedimentary environment. However, there is a limited understanding of how the sedimentary environment impacts the electrical resistivity and polarization properties of shale. This study conducts experimental tests on shale from the Longmaxi Formation in the extensively explored Sichuan Basin of China, employing techniques such as complex resistivity, X-ray diffraction, organic geochemistry, porosity analysis, elemental geochemistry, and argon-ion polishing scanning electron microscopy. The experimental findings reveal the following key points: 1) The core resistivity of the Longmaxi Formation shale ranges from 14.56 Ω·m to 115.96 Ω·m, with an average value of 64.08 Ω·m. The polarization rate ranges from 0.07 to 0.32, with an average of 0.15. 2) Redox conditions and paleoproductivity primarily influence TOC content and the formation of biogenic quartz. The content of pyrite is influenced by redox environments, while clay minerals and terrigenous quartz content are affected by paleoclimate and terrigenous input. 3) The interconnected network of organic matter pores with other types of pores and the content of pyrite are the main controlling factors affecting resistivity. The pyrite content also influences the polarization effect of shale. 4) Redox conditions and paleoproductivity positively influence conductivity and polarization, whereas terrigenous input and paleoclimate have inhibitory effects on both. This study provides essential theoretical insights for logging interpretation, electromagnetic exploration of shale gas and subsequent monitoring of hydraulic fracturing.