bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic venous collateral channel causing desaturation after bidirectional cavopulmonary anastomosis: percutaneous closure
Authors: Karur Satish , Mahima Jayaranganath , Nanjappa Manjunath Cholenahally 
Published: October 2010

AbstractAn infant with cyanotic cardiac disease that was palliated with a bidirectional cavopulmonary shunt developed progressive and worsening cyanosis 5 years after the surgical procedure. A large venous collateral was found to be decompressing the bidirectional Glenn shunt from the superior caval vein to the inferior caval vein and was percutaneously closed with a vascular plug. The unusually large venous collateral, and the excellent outcome associated with percutaneous procedure are discussed.
Long-term outcome after atrioventricular valve surgery following modified Fontan operation
Authors: Menon Shaji C. , Dearani Joseph A. , Cetta Frank 
Published: October 2010

AbstractObjectiveThe objective of this study was to evaluate the early and late results of atrioventricular valve surgery after Fontan operation.BackgroundAtrioventricular valve regurgitation is a known perioperative risk factor for Fontan operation. There are limited data on the outcomes of late atrioventricular valve surgery following Fontan operation.MethodsPatients who underwent atrioventricular valve surgery following Fontan procedure were identified from the Mayo Clinic Fontan database. Medical records were reviewed for pre-operative, operative, and post-operative clinical and haemodynamic data. All patients not known to be deceased were sent health status questionnaires.ResultsA total of 61 patients (28 females) underwent atrioventricular valve surgery following Fontan procedure. The median age at atrioventricular valve surgery was 14 years. The median duration between Fontan and atrioventricular valve surgery was 4.7 years. Median follow-up was 9 years. There were a total of 32 (52%) deaths with 8 (13%) within 30 days of surgery. The 5-, 10-, and 15-year survival rates were 67%, 57%, and 45%, respectively. On follow-up, 44 of 61 (72%) had arrhythmias, 21 of 29 (72%) were symptomatic, and 12 of 61 (20%) developed protein-losing enteropathy. On multivariate analysis, reduced ventricular function and development of protein-losing enteropathy were associated with decreased survival.ConclusionAtrioventricular valve surgery after Fontan procedure is associated with substantial late morbidity and mortality. Atrioventricular valve surgery in this cohort of patients portends poor long-term outcome and is associated with a high incidence of protein-losing enteropathy. Reduced ventricular function and development of protein-losing enteropathy were associated with decreased survival.
Nietzsche's Virtues: A Personal Inquiry
Authors: Solomon Robert C. 
Published: October 2010

Give style to your character, a great and rare art.Nietzsche Gay Science (290)What are we to make of Nietzsche? There has been an explosion of scholarship over the past twenty years, much of it revealing and insightful, a good deal of it controversial if not polemical. The controversy and polemics are for the most part straight from Nietzsche, of course, and the scholarly disputes over what he ‘really’ meant are rather innocuous and often academic compared with what Nietzsche meant (or might have meant) with his conscientiously inflammatory rhetoric and hyperbole. We have been treated to extended debates about Nietzsche's politics, his attacks on Christianity and morality, his famed notion of the übermensch and his less lampooned (but more edifying) doctrine of the ‘eternal recurrence’. We have recently heard Nietzsche reinterpreted as an analytic philosopher, as a deconstructionist, as a feminist, even as a closet Christian and a liberal. Stephen Aschheim suggests in his recent book that Nietzsche provides us with something like a Rorschach test, inviting readers with amazingly different commitments and ideologies to ‘make their own Nietzsche’ (as a Times Literary Supplement review bluntly put it). But there is another approach to Nietzsche, something quite different from interpreting him in terms of his various ‘theses’ and positions, unpacking his ‘system’ or repeating unhelpfully that he displayed no such coherence and consistency, something more than finding out ‘who’ Nietzsche is as opposed to what we have made out of him. The simplest way of getting at this alternative approach might be to ask, what Nietzsche would make of us? I grant that this is a bit cryptic, and it invites a variety of unflattering answers. But I think it is very much in the spirit of what he (and his spokesman Zarathustra) are all about. It is an intimately personal approach to Nietzsche, an approach that will, no doubt, be somewhat different for each and every one of us. But that, too, of course, is just what Nietzsche (and Zarathustra) would have demanded.
German Philosophy Today: Between Idealism, Romanticism, and Pragmatism
Authors: Bowie Andrew 
Published: October 2010

In his essayOn the History of Religion and Philosophy in Germany, of 1834, Heinrich Heine suggested to his French audience that the German propensity for ‘metaphysical abstractions’ had led many people to condemn philosophy for its failure to have a practical effect, Germany having only had its revolution in thought, while France had its in reality. Heine, albeit somewhat ironically, refuses to join those who condemn philosophy: ‘German philosophy is an important matter, which concerns the whole of humanity, and only the last grandchildren will be able to judge whether we should be blamed or praised for working out our philosophy before our revolution.’ He then makes the following prognosis:the German revolution will not be more mild and more gentle because it was preceded by Kantian critique, Fichtean transcendental idealism and even philosophy of nature. Revolutionary forces have developed via these doctrines which are just waiting for the day when they can break out and fill the world with horror and admiration. … Don't smile at my advice, the advice of a dreamer who warns you about Kantians, Fichteans and philosophers of nature. Don't smile at the fantast who expects the same revolution in the realm of appearance as took place in the realm of spirit. … A play will be performed in Germany in comparison with which the French Revolution could appear just as a harmless idyll (ibid., pp. 616–17).
A British sea: making sense of global space in the late nineteenth century
Authors: Pietsch Tamson 
Published: October 2010

AbstractIt is the contention of this article that historians of the nineteenth century need to think about notions of empire, nation, and race in the context of the social production of space. More specifically, it posits that the moving space of the steamship functioned as a particularly important site in which travellers reworked ideas about themselves and their worlds. Supporting this contention the article pays close attention to the journeys of J. T. Wilson, a young Scottish medical student who between 1884 and 1887 made three voyages to China and one to Australia. For it was in the space of the ship, literally moving along the routes of global trade, that Wilson forged a particular kind of British identity that collapsed the spaces of empire, elided differences among Britons and extended the boundaries of the British nation.
De/reconstructing critical psychological jurisprudence: strategies of resistance and struggles for justice
Authors: Arrigo Bruce A. 
Published: October 2010

AbstractThe development of an integrated critical psychological jurisprudence (PJ) continues to elude researchers in theoretical and applied contexts. Indeed, the radical potential of a synthetic PJ that furthers the political aims of social change, collective good and citizen justice has yet to be sufficiently problematised or systematically reviewed in the extant literature. This article begins to address this deficiency. First, the social philosophy that informs and underscores radicalised PJ is described. This includes commentary on its underlying symbolic, linguistic, material and cultural footing. Second, several well-rehearsed theoretical strains of critical PJ are summarily presented. These strains consist of anarchism, critical legal studies, feminist jurisprudence and complex systems science. Third, a conceptual integration is undertaken that links radicalised PJ’s grounding in social philosophy with its established theoretical variants. This synthesis demonstrates the probing political project of critical PJ, especially as a humanising strategy of resistance and an evolving struggle for justice. This is a political project that seeks to de/reconstruct the images (aesthetic), narratives (epistemology), embodiments (ethic) and reproductions (ontology) at the core of its nascent critique.
Annotating Whole Genome Sequencing in COSMIC (The Catalogue of Somatic Mutations in Cancer)
Authors: Breare D , Stratton M R , Shepherd R , Futreal P A , Menzies A , Leung K , Kok C Y , Forbes S A , Bindal N , Bamford S , Cole C G , Teague J , Jia M 
Published: October 2010

Abstract"COSMIC, the Catalogue Of Somatic Mutations In Cancer":http://www.sanger.ac.uk/cosmic is designed to store and display somatic mutation information relating to human cancers, combining detailed information on publications, samples and mutation types. The information is curated both from the primary literature and the laboratories at the Cancer Genome Project, Sanger Institute, UK, and then semi-automatically entered into the COSMIC database. The v47 release (May 2010) contained the curation of 9202 papers describing 116,977 mutations across 466,851 samples. In order to provide consistent annotation of the data, COSMIC has developed a classification system for cancer histology and tissue ontology, and adapted HGVS mutation nomenclature recommendations to describe the multiple mutation types involved in cancer.Cancer genetics is moving from systematic screens of candidate gene sets to whole genome sequencing analyses, and COSMIC displays and navigates this new data; we have recently included systematic gene screens and whole genome sequencing studies. COSMIC will annotate and display somatic mutation data that will be emerging from the "International Cancer Genome Consortium (ICGC)":http://www.icgc.org/ and "The Cancer Genome Atlas (TCGA)":http://cancergenome.nih.gov/ projects. New tools are being developed to interpret this genomic data with coding mutation annotations. In addition COSMIC will be expanded to curate and display data from mouse insertional mutagenesis screening and mouse cancer model exome/genome sequencing in the future. The data within COSMIC is freely available without restriction via a website, in datasheets on the "FTP site":ftp://ftp.sanger.ac.uk/pub/CGP/cosmic and through the "COSMIC Biomart":http://www.sanger.ac.uk/genetics/CGP/cosmic/biomart/martview/, available from the "COSMIC homepage":http://www.sanger.ac.uk/cosmic
Epidemiological Baseline of Influenza Virus in Wild Aquatic Birds in Hong Kong during the Pre-H5N1 Endemic Era
Authors: Chin Mario , Shortridge Kennedy 
Published: October 2010

AbstractInfluenza virus surveillance was conducted on wild ducks and shorebirds in Hong Kong at the Mai Po Nature Reserve to determine whether East Asian wild aquatic birds passing through or overwintering in Hong Kong are reservoirs of H5N1 influenza viruses and to establish an epidemiological baseline of influenza virus in wild aquatic birds during the pre-H5N1 endemic era. Three influenza viruses were isolated from 3178 faecal samples collected over three sampling periods from 1988 to 2001 during the southern and northern migration periods. The isolation rates and viruses were, respectively 0.08% (H10N5) in 1988 – 1990, 0.12% (H11N1) in 1998 and 0.09% (H3N8) in 1999 – 2001. Whereas tracheal and intestinal colon explants from representative shorebirds were susceptible to in vitro infection by the H10N5 virus, orally infected shorebirds were apparently not. Genetic analyses indicated that the nucleoprotein, matrix and nonstructural genes of the three viruses were related to those of aquatic bird viruses in Asia, but not to those of the human H5N1 virus. The present study provided epidemiological baseline information for future influenza virus surveillance in wild aquatic birds in southeast China.
Questionable Effectiveness of the QuantiFERON-TB Gold Test (Cellestis) as a Screening Tool in Healthcare Workers
Authors: Gandra Sumanth , Scott William S. , Somaraju Vijaya , Wang Huaping , Wilton Suzanne , Feigenbaum Michelle 
Published: October 2010

Objective.The Center for Disease Control and Prevention recommends the use of QuantiFERON TB Gold test (QFTG; Cellestis) in all situations where the tuberculin skin test (TST) is used. In November 2007, our institution replaced its screening-tool TST with the QFTG in-tube assay (QFT-GIT) for annual screening of latent tuberculosis infection among healthcare workers (HCWs). This study evaluated the effectiveness of QFT-GIT test as screening tool in HCWs at our institution.Methods.This retrospective study reviewed medical records of all HCWs who underwent screening with QFT-GIT from January 2008 through December 2008.Results.Among the 6,530 HCWs screened with QFT-GIT from January through December 2008, 287 had a positive test result. Of the 287, 123 had positive TST results in the past, meaning that 164 HCWs had newly diagnosed latent tuberculosis infection by QFT-GIT. Of the 164 HCWs, 135 were retested by QFT-GIT and were simultaneously tested with TST within 4 weeks after the initial QFT-GIT. Of these 135 HCWs, 66 reverted to negative results and results remained positive for 69 with QFT-GIT. Only 2 HCWs had a positive TST result.Conclusions.The disagreement between QFT-GIT and TST results and the high reversion rate with QFT-GIT raise concerns about the effectiveness of QFT-GIT as a sole screening test in HCWs.
The Arabidopsis Calcium-Dependent Protein Kinase, CPK6, Functions as a Positive Regulator of Methyl Jasmonate Signaling in Guard Cells
Authors: Munemasa Shintaro , Hossain Mohammad Anowar , Nakamura Yoshimasa , Mori Izumi C. , Murata Yoshiyuki 
Published: October 2010

Abstract
Previous studies have demonstrated that methyl jasmonate (MeJA) induces stomatal closure dependent on change of cytosolic free calcium concentration in guard cells. However, these molecular mechanisms of intracellular Ca2+ signal perception remain unknown. Calcium-dependent protein kinases (CDPKs) function as Ca2+ signal transducers in various plant physiological processes. It has been reported that four Arabidopsis (Arabidopsis thaliana) CDPKs, CPK3, CPK6, CPK4, and CPK11, are involved in abscisic acid signaling in guard cells. It is also known that there is an interaction between MeJA and abscisic acid signaling in guard cells. In this study, we examined the roles of these CDPKs in MeJA signaling in guard cells using Arabidopsis mutants disrupted in the CDPK genes. Disruption of the CPK6 gene impaired MeJA-induced stomatal closure, but disruption of the other CDPK genes did not. Despite the broad expression pattern of CPK6, we did not find other remarkable MeJA-insensitive phenotypes in the cpk6-1 mutant. The whole-cell patch-clamp analysis revealed that MeJA activation of nonselective Ca2+-permeable cation channels is impaired in the cpk6-1 mutant. Consistent with this result, MeJA-induced transient cytosolic free calcium concentration increments were reduced in the cpk6-1 mutant. MeJA failed to activate slow-type anion channels in the cpk6-1 guard cells. Production of early signal components, reactive oxygen species and nitric oxide, in guard cells was elicited by MeJA in the cpk6-1 mutant as in the wild type. These results provide genetic evidence that CPK6 has a different role from CPK3 and functions as a positive regulator of MeJA signaling in Arabidopsis guard cells.
Regulation of theChlamydomonasCell Cycle by a Stable, Chromatin-Associated Retinoblastoma Tumor Suppressor Complex
Authors: Olson Bradley J.S.C. , Oberholzer Michael , Li Yubing , Zones James M. , Kohli Harjivan S. , Bisova Katerina , Fang Su-Chiung , Meisenhelder Jill , Hunter Tony , Umen James G. 
Published: October 2010

AbstractWe examined the cell cycle dynamics of the retinoblastoma (RB) protein complex in the unicellular alga Chlamydomonas reinhardtii that has single homologs for each subunit—RB, E2F, and DP. We found that Chlamydomonas RB (encoded by MAT3) is a cell cycle–regulated phosphoprotein, that E2F1-DP1 can bind to a consensus E2F site, and that all three proteins interact in vivo to form a complex that can be quantitatively immunopurified. Yeast two-hybrid assays revealed the formation of a ternary complex between MAT3, DP1, and E2F1 that requires a C-terminal motif in E2F1 analogous to the RB binding domain of plant and animal E2Fs. We examined the abundance of MAT3/RB and E2F1-DP1 in highly synchronous cultures and found that they are synthesized and remain stably associated throughout the cell cycle with no detectable fraction of free E2F1-DP1. Consistent with their stable association, MAT3/RB and DP1 are constitutively nuclear, and MAT3/RB does not require DP1-E2F1 for nuclear localization. In the nucleus, MAT3/RB remains bound to chromatin throughout the cell cycle, and its chromatin binding is mediated through E2F1-DP1. Together, our data show that E2F-DP complexes can regulate the cell cycle without dissociation of their RB-related subunit and that other changes may be sufficient to convert RB-E2F-DP from a cell cycle repressor to an activator.
Assessment of liver fibrosis before and after antiviral therapy by different serum marker panels in patients with chronic hepatitis C
Authors: Martinez S. M. , Fernández‐Varo G. , González P. , Sampson E. , Bruguera M. , Navasa M. , Jiménez W. , Sánchez‐Tapias J. M. , Forns X. 
Published: October 2010

Aliment Pharmacol Ther 2011; 33: 138–148SummaryBackground  Liver biopsy is the reference standard to assess liver fibrosis in chronic hepatitis C.Aim  To validate and compare the diagnostic performance of non‐invasive tests for prediction of liver fibrosis severity and assessed changes in extracellular matrix markers after antiviral treatment.Methods  The performances of Forns’ score, AST to platelet ratio index (APRI), FIB‐4 index and Enhanced Liver Fibrosis (ELF) score were validated in 340 patients who underwent antiviral therapy. These scores were determined 24 weeks after treatment in 161 patients.Results  Forns’ score, APRI, FIB‐4 and ELF score showed comparable diagnostic accuracies for significant fibrosis [area under the receiver operating characteristic curve (AUROC) 0.83, 0.83, 0.85 and 0.81, respectively]. To identify cirrhosis, FIB‐4 index showed a significantly better performance over APRI and ELF score (AUROC 0.89 vs. 0.83 and 0.82, respectively). ELF score decreased significantly in patients with sustained virological response (SVR) (P < 0.0001) but remained unchanged in nonresponders. Non‐1 hepatitis C virus (HCV) genotype, baseline lower HCV RNA, glucose, hyaluronic acid and higher cholesterol levels were independently associated with SVR.Conclusions  Simple panel markers and ELF score are accurate at identifying significant fibrosis and cirrhosis in chronic hepatitis C. A decrease in ELF score after antiviral treatment reflects the impact of viral clearance in hepatic extracellular matrix and probably in the improvement of liver fibrosis.
Parenting, family functioning and lifestyle in a new culture: the case of African migrants in Melbourne, Victoria, Australia
Authors: Renzaho André M. N. , Green Julie , Mellor David , Swinburn Boyd 
Published: October 2010

ABSTRACTThis study documented the parenting styles among African migrants now living in Melbourne, Victoria, Australia, and assessed how intergenerational issues related to parenting in a new culture impact on family functioning and the modification of lifestyles. A total of 10 focus group discussions (five with parents and five with 13–17‐year‐old children; N = 85 participants) of 1.5–2 hours duration were conducted with Sudanese, Somali and Ethiopian migrant families. The analysis identified three discrete themes: (i) parenting‐related issues; (ii) family functioning and family relations; and (iii) lifestyle changes and health. African migrant parents were restrictive in their parenting; controlled children's behaviours and social development through strict boundary‐setting and close monitoring of interests, activities, and friends; and adopted a hierarchical approach to decision‐making while discouraging autonomy among their offspring. Programmes seeking to improve the health and welfare of African migrants in their host countries need to accommodate the cultural and social dimensions that shape their lives. Such programmes may need to be so broad as to apply an acculturation lens to planning, and to assist young people, parents and families in addressing intergenerational issues related to raising children and growing up in a different social and cultural milieu.
The prevalence and phenomenology of self‐injurious and aggressive behaviour in genetic syndromes
Authors: Arron K. , Oliver C. , Moss J. , Berg K. , Burbidge C. 
Published: October 2010

AbstractBackground Self‐injurious and aggressive behaviours are reported as components of some behavioural phenotypes but there are few studies comparing across syndrome groups. In this study we examined the prevalence of these behaviours and the associated person characteristics in seven genetic syndromes.Methods Questionnaire data on self‐injury and aggression, mood, hyperactivity, autism spectrum disorder and repetitive behaviour were collected on Angelman (AS,n = 104), Cornelia de Lange (CdLS, 101), Cri du Chat (CdCS, 58), Fragile X (FXS, 191), Lowe (LS, 56), Prader–Willi (PWS, 189) and Smith–Magenis (SMS, 42) syndromes.Results A significantly higher prevalence of self‐injury was evident in CdCS, CdLS, FXS, PWS, LS and SMS. The prevalence of aggression was significantly heightened in AS and SMS. Self‐injury was associated with repetitive and impulsive behaviour in CdLS, FXS, PWS and LS. Impulsivity and overactivity were significantly higher in those showing aggression across all syndrome groups.Conclusions These data quantify the risk for self‐injury and aggression in the syndromes studied with implications for early intervention. The associations between these behaviours and person characteristics both within and between syndromes warrant further research.