bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of collagen oxidation and cross linking in regenerating and irreversibly infarcted myocardium
Authors: Akam-Baxter Eman A. , Bergemann David , Ridley Sterling J. , To Samantha , Andrea Brittany , Moon Brianna , Ma Hua , Zhou Yirong , Aguirre Aaron , Caravan Peter , Gonzalez-Rosa Juan Manuel , Sosnovik David E. 
Published: June 2024

AbstractIn mammalian hearts myocardial infarction produces a permanent collagen-rich scar. Conversely, in zebrafish a collagen-rich scar forms but is completely resorbed as the myocardium regenerates. The formation of cross-links in collagen hinders its degradation but cross-linking has not been well characterized in zebrafish hearts. Here, a library of fluorescent probes to quantify collagen oxidation, the first step in collagen cross-link (CCL) formation, was developed. Myocardial injury in mice or zebrafish resulted in similar dynamics of collagen oxidation in the myocardium in the first month after injury. However, during this time, mature CCLs such as pyridinoline and deoxypyridinoline developed in the murine infarcts but not in the zebrafish hearts. High levels of newly oxidized collagen were still seen in murine scars with mature CCLs. These data suggest that fibrogenesis remains dynamic, even in mature scars, and that the absence of mature CCLs in zebrafish hearts may facilitate their ability to regenerate.
Evolution of the ionisation energy with the stepwise growth of chiral clusters of [4]helicene
Authors: Domingos Sérgio R. , Tikhonov Denis S. , Steber Amanda L. , Eschenbach Patrick , Gruet Sebastien , Hrodmarsson Helgi R. , Martin Kévin , Garcia Gustavo A. , Nahon Laurent , Neugebauer Johannes , Avarvari Narcis , Schnell Melanie 
Published: June 2024

AbstractPolycyclic aromatic hydrocarbons (PAHs) are widely established as ubiquitous in the interstellar medium (ISM), but considering their prevalence in harsh vacuum environments, the role of ionisation in the formation of PAH clusters is poorly understood, particularly if a chirality-dependent aggregation route is considered. Here we report on photoelectron spectroscopy experiments on [4]helicene clusters performed with a vacuum ultraviolet synchrotron beamline. Aggregates (up to the heptamer) of [4]helicene, the smallest PAH with helical chirality, were produced and investigated with a combined experimental and theoretical approach using several state-of-the-art quantum-chemical methodologies. The ionisation onsets are extracted for each cluster size from the mass-selected photoelectron spectra and compared with calculations of vertical ionisation energies. We explore the complex aggregation topologies emerging from the multitude of isomers formed through clustering of P and M, the two enantiomers of [4]helicene. The very satisfactory benchmarking between experimental ionisation onsets vs. predicted ionisation energies allows the identification of theoretically predicted potential aggregation motifs and corresponding energetic ordering of chiral clusters. Our structural models suggest that a homochiral aggregation route is energetically favoured over heterochiral arrangements with increasing cluster size, hinting at potential symmetry breaking in PAH cluster formation at the scale of small grains.
Enhanced quantum state transfer by circumventing quantum chaotic behavior
Authors: Xiang Liang , Chen Jiachen , Zhu Zitian , Song Zixuan , Bao Zehang , Zhu Xuhao , Jin Feitong , Wang Ke , Xu Shibo , Zou Yiren , Li Hekang , Wang Zhen , Song Chao , Yue Alexander , Partridge Justine , Guo Qiujiang , Mondaini Rubem , Wang H. , Scalettar Richard T. 
Published: June 2024

AbstractThe ability to realize high-fidelity quantum communication is one of the many facets required to build generic quantum computing devices. In addition to quantum processing, sensing, and storage, transferring the resulting quantum states demands a careful design that finds no parallel in classical communication. Existing experimental demonstrations of quantum information transfer in solid-state quantum systems are largely confined to small chains with few qubits, often relying upon non-generic schemes. Here, by using a superconducting quantum circuit featuring thirty-six tunable qubits, accompanied by general optimization procedures deeply rooted in overcoming quantum chaotic behavior, we demonstrate a scalable protocol for transferring few-particle quantum states in a two-dimensional quantum network. These include single-qubit excitation, two-qubit entangled states, and two excitations for which many-body effects are present. Our approach, combined with the quantum circuit’s versatility, paves the way to short-distance quantum communication for connecting distributed quantum processors or registers, even if hampered by inherent imperfections in actual quantum devices.
The UK Soft Drinks Industry Levy and childhood hospital admissions for asthma in England
Authors: Rogers Nina T. , Cummins Steven , Jones Catrin P. , Mytton Oliver T. , Roberts Chrissy H. , Shaheen Seif O. , Shah Syed Ahmar , Sheikh Aziz , White Martin , Adams Jean 
Published: June 2024

AbstractSugar sweetened beverage consumption has been suggested as a risk factor for childhood asthma symptoms. We examined whether the UK Soft Drinks Industry Levy (SDIL), announced in March 2016 and implemented in April 2018, was associated with changes in National Health Service hospital admission rates for asthma in children, 22 months post-implementation of SDIL. We conducted interrupted time series analyses (2012-2020) to measure changes in monthly incidence rates of hospital admissions. Sub-analysis was by age-group (5-9,10-14,15-18 years) and neighbourhood deprivation quintiles. Changes were relative to counterfactual scenarios where the SDIL wasn’t announced, or implemented. Overall, incidence rates reduced by 20.9% (95%CI: 29.6-12.2). Reductions were similar across age-groups and deprivation quintiles. These findings give support to the idea that implementation of a UK tax intended to reduce childhood obesity may have contributed to a significant unexpected and additional public health benefit in the form of reduced hospital admissions for childhood asthma.
Generative learning facilitated discovery of high-entropy ceramic dielectrics for capacitive energy storage
Authors: Li Wei , Shen Zhong-Hui , Liu Run-Lin , Chen Xiao-Xiao , Guo Meng-Fan , Guo Jin-Ming , Hao Hua , Shen Yang , Liu Han-Xing , Chen Long-Qing , Nan Ce-Wen 
Published: June 2024

AbstractDielectric capacitors offer great potential for advanced electronics due to their high power densities, but their energy density still needs to be further improved. High-entropy strategy has emerged as an effective method for improving energy storage performance, however, discovering new high-entropy systems within a high-dimensional composition space is a daunting challenge for traditional trial-and-error experiments. Here, based on phase-field simulations and limited experimental data, we propose a generative learning approach to accelerate the discovery of high-entropy dielectrics in a practically infinite exploration space of over 1011 combinations. By encoding-decoding latent space regularities to facilitate data sampling and forward inference, we employ inverse design to screen out the most promising combinations via a ranking strategy. Through only 5 sets of targeted experiments, we successfully obtain a Bi(Mg0.5Ti0.5)O3-based high-entropy dielectric film with a significantly improved energy density of 156 J cm−3 at an electric field of 5104 kV cm−1, surpassing the pristine film by more than eight-fold. This work introduces an effective and innovative avenue for designing high-entropy dielectrics with drastically reduced experimental cycles, which could be also extended to expedite the design of other multicomponent material systems with desired properties.
Heterogeneous associations of multiplexed environmental factors and multidimensional aging metrics
Authors: Pu Fan , Chen Weiran , Li Chenxi , Fu Jingqiao , Gao Weijing , Ma Chao , Cao Xingqi , Zhang Lingzhi , Hao Meng , Zhou Jin , Huang Rong , Ma Yanan , Hu Kejia , Liu Zuyun 
Published: June 2024

AbstractComplicated associations between multiplexed environmental factors and aging are poorly understood. We manipulated aging using multidimensional metrics such as phenotypic age, brain age, and brain volumes in the UK Biobank. Weighted quantile sum regression was used to examine the relative individual contributions of multiplexed environmental factors to aging, and self-organizing maps (SOMs) were used to examine joint effects. Air pollution presented a relatively large contribution in most cases. We also found fair heterogeneities in which the same environmental factor contributed inconsistently to different aging metrics. Particulate matter contributed the most to variance in aging, while noise and green space showed considerable contribution to brain volumes. SOM identified five subpopulations with distinct environmental exposure patterns and the air pollution subpopulation had the worst aging status. This study reveals the heterogeneous associations of multiplexed environmental factors with multidimensional aging metrics and serves as a proof of concept when analyzing multifactors and multiple outcomes.
Thymoquinone as an electron transfer mediator to convert Type II photosensitizers to Type I photosensitizers
Authors: Zhuang Jiahao , Qi Guobin , Feng Yecheng , Wu Min , Zhang Hang , Wang Dandan , Zhang Xianhe , Chong Kok Chan , Li Bowen , Liu Shitai , Tian Jianwu , Shan Yi , Mao Duo , Liu Bin 
Published: June 2024

AbstractThe development of Type I photosensitizers (PSs) is of great importance due to the inherent hypoxic intolerance of photodynamic therapy (PDT) in the hypoxic microenvironment. Compared to Type II PSs, Type I PSs are less reported due to the absence of a general molecular design strategy. Herein, we report that the combination of typical Type II PS and natural substrate carvacrol (CA) can significantly facilitate the Type I pathway to efficiently generate superoxide radical (O2–•). Detailed mechanism study suggests that CA is activated into thymoquinone (TQ) by local singlet oxygen generated from the PS upon light irradiation. With TQ as an efficient electron transfer mediator, it promotes the conversion of O2 to O2–• by PS via electron transfer-based Type I pathway. Notably, three classical Type II PSs are employed to demonstrate the universality of the proposed approach. The Type I PDT against S. aureus has been demonstrated under hypoxic conditions in vitro. Furthermore, this coupled photodynamic agent exhibits significant bactericidal activity with an antibacterial rate of 99.6% for the bacterial-infection female mice in the in vivo experiments. Here, we show a simple, effective, and universal method to endow traditional Type II PSs with hypoxic tolerance.
Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles
Authors: Jiang Ling-Feng , Wu Shao-Hua , Jiang Yu-Xuan , Ma Hong-Xiang , He Jia-Jun , Bi Yang-Bo , Kong De-Yi , Cheng Yi-Fei , Cheng Xuan , Deng Qing-Hai 
Published: June 2024

AbstractChiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited catalytic systems and substrate scope. Herein, we report an enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides with a readily available and potent azido transfer reagent via copper catalysis, which affords a variety of chiral 1,2,3-triazoles with up to 99% yield and 95% ee under mild conditions. Notably, chiral 1,5-disubstituted triazoles that have not been accessed by previous asymmetric click reactions are also prepared with good functional group tolerance.
Emergent normal fluid in the superconducting ground state of overdoped cuprates
Authors: Ye Shusen , Xu Miao , Yan Hongtao , Li Zi-Xiang , Zou Changwei , Li Xintong , Hao Zhenqi , Yin Chaohui , Chen Yiwen , Zhou Xingjiang , Lee Dung-Hai , Wang Yayu 
Published: June 2024

AbstractThe microscopic mechanism for the disappearance of superconductivity in overdoped cuprates is still under heated debate. Here we use scanning tunneling spectroscopy to investigate the evolution of quasiparticle interference phenomenon in Bi2Sr2CuO6+δ over a wide range of hole densities. We find that when the system enters the overdoped regime, a peculiar quasiparticle interference wavevector with arc-like pattern starts to emerge even at zero bias, and its intensity grows with increasing doping level. Its energy dispersion is incompatible with the octet model for d-wave superconductivity, but is highly consistent with the scattering interference of gapless normal carriers. The gapless quasiparticles are mainly located near the antinodes and are independent of temperature, consistent with the disorder scattering mechanism. We propose that a branch of normal fluid emerges from the pair-breaking scattering between flat antinodal bands in the quantum ground state, which is the primary cause for the reduction of superfluid density and suppression of superconductivity in overdoped cuprates.
PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development
Authors: Bao Haili , Sun Yang , Deng Na , Zhang Leilei , Jia Yuanyuan , Li Gaizhen , Gao Yun , Li Xinyi , Tang Yedong , Cai Han , Lu Jinhua , Wang Haibin , Deng Wenbo , Kong Shuangbo 
Published: June 2024

AbstractThe differentiation of the stroma is a hallmark event during postnatal uterine development. However, the spatiotemporal changes that occur during this process and the underlying regulatory mechanisms remain elusive. Here, we comprehensively delineated the dynamic development of the neonatal uterus at single-cell resolution and characterized two distinct stromal subpopulations, inner and outer stroma. Furthermore, single-cell RNA sequencing revealed that uterine ablation of Pr-set7, the sole methyltransferase catalyzing H4K20me1, led to a reduced proportion of the inner stroma due to massive cell death, thus impeding uterine development. By combining RNA sequencing and epigenetic profiling of H4K20me1, we demonstrated that PR-SET7-H4K20me1 either directly repressed the transcription of interferon stimulated genes or indirectly restricted the interferon response via silencing endogenous retroviruses. Declined H4K20me1 level caused viral mimicry responses and ZBP1-mediated apoptosis and necroptosis in stromal cells. Collectively, our study provides insight into the epigenetic machinery governing postnatal uterine stromal development mediated by PR-SET7.
Multivalent mRNA-DTP vaccines are immunogenic and provide protection from Bordetella pertussis challenge in mice
Authors: Wolf M. Allison , O’Hara Joanne M. , Bitzer Graham J. , Narayanan Elisabeth , Boehm Dylan T. , Bevere Justin R. , DeJong Megan A. , Hall Jesse M. , Wong Ting Y. , Falcone Samantha , Deal Cailin E. , Richards Angelene , Green Shannon , Nguyen Brenda , King Emily , Ogega Clinton , Russo Lisa , Sen-Kilic Emel , Plante Obadiah , Himansu Sunny , Barbier Mariette , Carfi Andrea , Damron F. Heath 
Published: June 2024

AbstractAcellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease and infant mortality, but immunity to Bordetella pertussis infection wanes significantly over time resulting in cyclic epidemics of pertussis. The messenger RNA (mRNA) vaccine platform provides an opportunity to address complex bacterial infections with an adaptable approach providing Th1-biased responses. In this study, immunogenicity and challenge models were used to evaluate the mRNA platform with multivalent vaccine formulations targeting both B. pertussis antigens and diphtheria and tetanus toxoids. Immunization with mRNA formulations were immunogenetic, induced antigen specific antibodies, as well as Th1 T cell responses. Upon challenge with either historical or contemporary B. pertussis strains, 6 and 10 valent mRNA DTP vaccine provided protection equal to that of 1/20th human doses of either DTaP or whole cell pertussis vaccines. mRNA DTP immunized mice were also protected from pertussis toxin challenge as measured by prevention of lymphocytosis and leukocytosis. Collectively these pre-clinical mouse studies illustrate the potential of the mRNA platform for multivalent bacterial pathogen vaccines.
RETRACTED ARTICLE: Tumour microenvironment programming by an RNA–RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma
Authors: Wu Lele , Zhao Zheng , Shin Yong Jae , Yin Yiyun , Raju Anandhkumar , Vaiyapuri Thamil Selvan , Idzham Khaireen , Son Miseol , Lee Yeri , Sa Jason K. , Chua Joelle Yi Heng , Unal Bilal , Zhai You , Fan Wenhua , Huang Lijie , Hu Huimin , Gunaratne Jayantha , Nam Do-Hyun , Jiang Tao , Tergaonkar Vinay 
Published: June 2024

Abstract
Patients with IDH-wild-type glioblastomas have a poor five-year survival rate along with limited treatment efficacy due to immune cell (glioma-associated microglia and macrophages) infiltration promoting tumour growth and resistance. To enhance therapeutic options, our study investigated the unique RNA–RNA-binding protein complex LOC–DHX15. This complex plays a crucial role in driving immune cell infiltration and tumour growth by establishing a feedback loop between cancer and immune cells, intensifying cancer aggressiveness. Targeting this complex with blood–brain barrier-permeable small molecules improved treatment efficacy, disrupting cell communication and impeding cancer cell survival and stem-like properties. Focusing on RNA–RNA-binding protein interactions emerges as a promising approach not only for glioblastomas without the IDH mutation but also for potential applications beyond cancer, offering new avenues for developing therapies that address intricate cellular relationships in the body.
Harnessing Maxwell’s demon to establish a macroscale concentration gradient
Authors: Pruchyathamkorn Jiratheep , Nguyen Bao-Nguyen T. , Grommet Angela B. , Novoveska Miroslava , Ronson Tanya K. , Thoburn John D. , Nitschke Jonathan R. 
Published: June 2024

AbstractMaxwell’s demon describes a thought experiment in which a ‘demon’ regulates the flow of particles between two adjoining spaces, establishing a potential gradient without appearing to do work. This seeming paradox led to the understanding that sorting entails thermodynamic work, a foundational concept of information theory. In the past centuries, many systems analogous to Maxwell’s demon have been introduced in the form of molecular information, molecular pumps and ratchets. Here we report a functional example of a Maxwell’s demon that pumps material over centimetres, whereas previous examples operated on a molecular scale. In our system, this demon drives directional transport of o-fluoroazobenzene between the arms of a U-tube apparatus upon light irradiation, transiting through an aqueous membrane containing a coordination cage. The concentration gradient thus obtained is further harnessed to drive naphthalene transport in the opposite direction.
Evidence for transient morning water frost deposits on the Tharsis volcanoes of Mars
Authors: Valantinas A. , Thomas N. , Pommerol A. , Karatekin O. , Ruiz Lozano L. , Senel C. B. , Temel O. , Hauber E. , Tirsch D. , Bickel V. T. , Munaretto G. , Pajola M. , Oliva F. , Schmidt F. , Thomas I. , McEwen A. S. , Almeida M. , Read M. , Rangarajan V. G. , El-Maarry M. R. , Re C. , Carrozzo F. G. , D’Aversa E. , Daerden F. , Ristic B. , Patel M. R. , Bellucci G. , Lopez-Moreno J. J. , Vandaele A. C. , Cremonese G. 
Published: June 2024

AbstractThe present-day water cycle on Mars has implications for habitability and future human exploration. Water ice clouds and water vapour have been detected above the Tharsis volcanic province, suggesting the active exchange of water between regolith and atmosphere. Here we report observational evidence for extensive transient morning frost deposits on the calderas of the Tharsis volcanoes (Olympus, Arsia and Ascraeus Montes, and Ceraunius Tholus) using high-resolution colour images from the Colour and Stereo Surface Imaging System on board the European Space Agency’s Trace Gas Orbiter. The transient bluish deposits appear on the caldera floor and rim in the morning during the colder Martian seasons but are not present by afternoon. The presence of water frost is supported by spectral observations, as well as independent imagery from the European Space Agency’s Mars Express orbiter. Climate model simulations further suggest that early-morning surface temperatures at the high altitudes of the volcano calderas are sufficiently low to support the daily condensation of water—but not CO2—frost. Given the unlikely seasonal nature of volcanic outgassing, we suggest the observed frost is atmospheric in origin, implying the role of microclimate in local frost formation and a contribution to the broader Mars water cycle.
A formulation for asphalt concrete air void during service life by adopting a hybrid evolutionary polynomial regression and multi-gene genetic programming
Authors: Ghanizadeh Ali Reza , Amlashi Amir Tavana , Bahrami Alireza , Isleem Haytham F. , Dessouky Samer 
Published: June 2024

AbstractBitumen, aggregate, and air void (VA) are the three primary ingredients of asphalt concrete. VA changes over time as a function of four factors: traffic loads and repetitions, environmental regimes, compaction, and asphalt mix composition. Due to the high as-constructed VA content of the material, it is expected that VA will reduce over time, causing rutting during initial traffic periods. Eventually, the material will undergo shear flow when it reaches its densest state with optimum aggregate interlock or refusal VA content. Therefore, to ensure the quality of construction, VA in asphalt mixture need to be modeled throughout the service life. This study aims to implement a hybrid evolutionary polynomial regression (EPR) combined with a teaching–learning based optimization (TLBO) algorithm and multi-gene genetic programming (MGGP) to predict the VA percentage of asphalt mixture during the service life. For this purpose, 324 data records of VA were collected from the literature. The variables selected as inputs were original as-constructed VA, $${VA}_{orig}$$

VA

orig

(%); mean annual air temperature, $$MAAT$$

MAAT

(°F); original viscosity at 77 °F, $${\eta }_{orig,77}$$

η

o
r
i
g
,
77

(Mega-Poises); and $$time$$

time

(months). EPR-TLBO was found to be superior to MGGP and existing empirical models due to the interquartile ranges of absolute error boxes equal to 0.67%. EPR-TLBO had an R2 value of more than 0.90 in both the training and testing phases, and only less than 20% of the records were predicted utilizing this model with more than 20% deviation from the observed values. As determined by the sensitivity analysis, $${\eta }_{orig,77}$$

η

o
r
i
g
,
77

is the most significant of the four input variables, while time is the least one. A parametric study showed that regardless of $$MAAT$$

MAAT

, $${\eta }_{orig,77},$$

η

o
r
i
g
,
77

,

of 0.3 Mega-Poises, and $${VA}_{orig}$$

VA

orig

above 6% can be ideal for improving the pavement service life. It was also witnessed that with an increase of $$MAAT$$

MAAT

from 37 to 75 °F, the serviceability of asphalt concrete takes 15 months less on average.