bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSMENT OF KNOWLEDGE, ATTITUDES, AND PRACTICES REGARDING CRICOID PRESSURE APPLICATION IN EMERGENCY SURGERIES AMONG ANESTHESIOLOGISTS AT TERTIARY CARE HOSPITALS IN KARACHI
Authors: Suraj Kumar  , Kashif Naeem  , Mahendar Wanwari  , Tarique Aziz  , Adeel ur Rehman  , Vinod Kumar  
Published: February 2025

Introduction: Cricoid pressure (CP), established by Brian Sellick in 1961, is a method employed to avert regurgitation and aspiration during endotracheal intubation. It is commonly employed in emergency procedures, where the danger of aspiration is increased due to full stomach conditions. Although commonly employed during rapid sequence induction and intubation, the effectiveness and appropriate implementation of CP remain contentious issues.
Objectives: To assess the knowledge, attitudes, practices, and adherence rates of anesthesiologists regarding cricoid pressure application during rapid sequence induction in emergency settings at tertiary care hospitals in Karachi, Sindh, Pakistan.
Method A cross-sectional study was undertaken at The Indus Hospital, Aga Khan Hospital, Civil Hospital, JPMC, LNH, SIUT, Patel Hospital, and Abbasi Shaheed Hospital in Karachi over a six-month period from June 23, 2023, to December 23, 2023. A total of 85 anaesthesiologists were included in the present study. The questionnaire comprises three primary sections: knowledge of cricoid pressure, attitudes, and a final component addressing attitudes.
Results: The mean age of the patients was 30.73 ± 4.59 years. Merely 25% of participants accurately identified the anatomical position of the cricoid cartilage. Approximately 99% recognised that cricoid pressure is utilised to avert stomach aspiration during the induction of anaesthesia. Moreover, around 86% of individuals indicated that they acquired information predominantly through clinical practice.
Conclusion: In conclusion, our findings underscore the necessity for focused educational initiatives, standardised training programs, and continuous professional development to guarantee a uniform and evidence-based application of cricoid pressure in peri-operative care.
El uso de juegos didácticos para el desarrollo de la compresión oral del idioma inglés
Authors: López Castillo Magdalena Lucía 
Published: February 2025

Los juegos didácticos estimulan la participación activa y mejoran la comprensión oral del idioma inglés. El objetivo del estudio fue evaluar la influencia del uso de los juegos didácticos en el desarrollo de la compresión oral del idioma inglés, en estudiantes de la Licenciatura de Biología orientada a la educación secundaria del recinto Luis Napoleón Núñez Molina, ISFODOSU. Se trabajó un enfoque mixto y un diseño cuasi experimental. La población fue de 23 estudiantes y 2 docentes, clasificados en un grupo experimental y un grupo control. Los resultados destacan que los juegos didácticos tuvieron una incidencia baja el desarrollo de la comprensión oral de los estudiantes, sin embargo, valoraron el uso de esta estrategia como efectiva y dinámica para el desarrollo de las competencias lingüísticas del idioma. Se concluye que la implementación de juegos didácticos en el grupo experimental mejoró significativamente su nivel de comprensión oral del idioma inglés.
“АЛПОМИШ” ДОСТОНИДАГИ ЗИНДОН ВОҚЕАСИ ВА ҲАКИМБЕКНИНГ СИНОВЛАРИ
Authors: Соннибоев Олим Нодирович 
Published: February 2025

Алпомиш” халқ қаҳрамонлик эпоси ҳисобланиб, унда қаҳрамонлик, мардлик, миллатпарварлик, адолат, ўзаро қўшничилик, ватанпарварлик, биродарлик, вафодорлик туйғулари намоён этилган. Мазкур асар минг йиллардан буён вужудга келиб, асрлар давомида халқ бахшилари, шоирлар томонидан куйга солиниб, такомиллашиб келди. Ўзбекнинг узоқ ўтмиши, расм-русумлари, ҳаёт тажрибасидан ўтган анъаналари, курашлари, ташвишлари, қувончлари ўзининг бадиий ифодасини топган достонда Алпомишнинг жасорати, Барчиной садоқати, Қоражон, Қалдирғочой каби бир қатор образлар тасвирланган бўлиб, қуйида «Алпомиш» достонидаги асосий образларга тавсиф бериб, бугунги кун ёшлари онгига қандай таъсир қилишига эътибор қаратамиз.
KIYIM TAYYORLASH JARONIDAGI ASOSIY TEXNOLOGIK JARAYONLAR VA TALABLAR
Authors: Muxammadova Zebiniso Olimovna, Temirova Gulnoz Ibodovna, Yuldasheva Sitorabonu Ramazonovna 
Published: February 2025

Inson tanasini himoya qiluvchi har qanday kiyim gigiyenik va texnikaviy jihatdan uning nimaga mо’lallanganiga mos bо’lishi zarur. Ustki va qishgi kiyimlar issiq saqlaydigan, yengil va yozgi kiyimlar issiqlikka yuqori darajada qarshilik kо’rsatadigan, plash suv о’tkazmaydigan, ich kiyim esa havo va bug’ni yaxshi о’tkazadigan, nam shimadigan bо’lishi kerak. Texnologik qulay bo’lgan har qanday kiyim ma’lum daraja pishiq, chidamli bо’lishi, maksimal darajada yengil va mayin bо’lishi asosiy talablardan.
ҲАМЗА ШАХСИЯТИ, АДАБИЁТИ ВА АБАДИЯТИ
Authors: Хўжамбердиев Шерзод 
Published: February 2025

Мазкур мақолада Ҳамза Ҳакимзоданинг шахсияти, бу масалага бугунги кун назари билан қараш, ўтмишда шоир шахсияти юзасидан баёнланган битикларга муносабат, шоир ҳаёт йўлидаги энг муҳим нуқталар, бу серқирра ижодкорнинг адабиёт ва санъатнинг турли соҳалари бўйича ёзган асарлари, маориф ва миллий маданият соҳалари бўйича қилган ишлари юзасидан мухтасар сўз юритилади. Шу билан бирга, Ҳамза Ҳакимзода шахсияти ва асарларига бугунги мезонлар билан қараш қай даражада эканлиги хусусидаги мулоҳазалар баён қилинади. Эндиликда адибнинг асарларига қай йўсинда ёндашув кераклиги борасида ҳам айрим таклифлар берилади. Истиқлол даврида бу серқирра ижодкорнинг шахсияти ва фаолиятига баҳо беришда амалга оширилган ишлар, турли позициядан туриб ёзилган баъзи мақолалар, ҳужжатли бадиий асарларга муносабат ҳам эътибордан четда қолмаган.
Salivary gland transcriptomics of the cotton aphid Aphis gossypii and comparative analysis with other sap‐sucking insects
Authors: Pavithran Shanmugasundram , Murugan Marimuthu , Mannu Jayakanthan , Sathyaseelan Chakkarai , Balasubramani Venkatasamy , Harish Sankarasubramanian , Natesan Senthil 
Published: June 2024

AbstractAphids are sap‐sucking insects responsible for crop losses and a severe threat to crop production. Proteins in the aphid saliva are integral in establishing an interaction between aphids and plants and are responsible for host plant adaptation. The cotton aphid, Aphis gossypii (Hemiptera: Aphididae) is a major pest of Gossypium hirsutum. Despite extensive studies of the salivary proteins of various aphid species, the components of A. gossypii salivary glands are unknown. In this study, we identified 123,008 transcripts from the salivary gland of A. gossypii. Among those, 2933 proteins have signal peptides with no transmembrane domain known to be secreted from the cell upon feeding. The transcriptome includes proteins with more comprehensive functions such as digestion, detoxification, regulating host defenses, regulation of salivary glands, and a large set of uncharacterized proteins. Comparative analysis of salivary proteins of different aphids and other insects with A. gossypii revealed that 183 and 88 orthologous clusters were common in the Aphididae and non‐Aphididae groups, respectively. The structure prediction for highly expressed salivary proteins indicated that most possess an intrinsically disordered region. These results provide valuable reference data for exploring novel functions of salivary proteins in A. gossypii with their host interactions. The identified proteins may help develop a sustainable way to manage aphid pests.
Dietary supplement of sodium butyrate improves the growth performance and intestinal health by targeting Wnt/β‐catenin signaling pathway in rabbits
Authors: Ni Mengke , Wang Zhitong , Li Zhichao , Chen Mengjuan , He Hui , Cai Hanfang , Chen Zhi , Li Ming , Xu Huifen 
Published: June 2024

AbstractSupplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth performance and health of animals, but its effects on rabbits have not been well understood. Therefore, this study aimed to investigate the effects of SB supplementation on growth performance, meat quality, and intestinal health of rabbits by evaluating feed intake and efficiency, diarrhea index, blood and cecum metabolites, cecal pH and short‐chain fatty acids (SCFAs), histological staining, nutritional composition of meat, and gene expression profile of cecum. A total of 14 weaned male New Zealand White rabbits (35 ± 2 days, 1.70 ± 0.09 kg) were randomly divided into two groups: rabbits in Control group were fed normally with the basal diet, and rabbits in Butyrate group were supplemented with 0.75 g/kg SB on the basis of the basal diet. After a 1‐week acclimatization period, the formal trial lasted for 10 weeks. Results suggest that dietary SB reduced the feed conversion ratio and diarrhea index of rabbits (p < 0.05). SB treatment significantly increased serum glutamyl transpeptidase, total bile acid, total cholesterol, triglyceride, and glucose levels and decreased tCO2 content relative to the Control group (p < 0.05). Meanwhile, crude ash content in rabbits' meat was significantly increased by SB treatment (p < 0.05). Furthermore, SB treatment significantly increased the integrity of epithelial villi and number of goblet cells in the cecum and decreased cecal pH compared with the Control group. Dietary SB also upregulated levels of Na+‐K+ ATPase, Ca2+‐Mg2+ ATPase, total superoxide dismutase, and glutathione peroxidase in cecum. SCFAs analysis revealed that dietary supplementation with SB increases butyric acid in the cecum contents. Furthermore, SB supplementation is demonstrated to stimulate the proliferation and migration of cecal epithelial cells through activating Wnt/β‐catenin pathways in rabbits both in vitro and in vivo by using transcriptome sequencing and gene function verification technologies. Taken together, our findings provide a theoretical basis for the application of SB as an alternative to antibiotics in livestock production.
Geochemistry of forty‐one eclogitic and pyroxenitic mantle xenoliths from the Central Slave Craton, Canada (Ekati Diamond Mine)
Authors: Jacob D. E. , Fung A. 
Published: June 2024

AbstractThis article describes a novel dataset on non‐diamondiferous eclogite and garnet pyroxenite xenoliths from four kimberlite pipes of the Ekati Diamond Mine (Central Slave Craton, Canada). Xenoliths brought to the surface by kimberlite eruptions are direct sources of information on the composition and evolution of the Earth's mantle. Eclogite and garnet pyroxenite xenoliths, specifically, are testimony of subduction into, and metasomatism of, the mantle beneath cratons. Furthermore, these rocks are major hosts for diamond and thus an important part of the deep carbon cycle. The sample suite consists of 41 small xenoliths (2–5 cm) recovered from drill cores. The dataset includes major and trace element concentrations for garnet, clinopyroxene and ilmenite, as well as stable oxygen isotope compositions of garnets. Strontium and neodymium isotopic compositions are reported for garnet and clinopyroxene for four samples which were large enough to allow for analysis. Overall, this dataset significantly expands and complements existing datasets on diamondiferous and non‐diamondiferous xenoliths from the Slave Craton in Canada, furthering our understanding of the composition of the Slave subcratonic lithosphere. The dataset includes several samples with rare mineral assemblages, including an olivine‐bearing eclogite as well as ilmenite and apatite‐bearing garnet‐pyroxenites, and thus provides data shedding light on rarely reported compositional nuances in xenolith suites found in kimberlites.
Relationships between matrix mineralization, oxidative metabolism, and mitochondrial structure during ATDC5 murine chondroprogenitor cell line differentiation
Authors: Blank Kevin , Ekanayake Derrick , Cooke Margaret , Bragdon Beth , Hussein Amira , Gerstenfeld Louis 
Published: June 2024

AbstractThe mechanistic relationships between the progression of growth chondrocyte differentiation, matrix mineralization, oxidative metabolism, and mitochondria content and structure were examined in the ATDC5 murine chondroprogenitor cell line. The progression of chondrocyte differentiation was associated with a statistically significant (p ≤ 0.05) ~2‐fold increase in oxidative phosphorylation. However, as matrix mineralization progressed, oxidative metabolism decreased. In the absence of mineralization, cartilage extracellular matrix mRNA expression for Col2a1, Aggrecan, and Col10a1 were statistically (p ≤ 0.05) ~2–3‐fold greater than observed in mineralizing cultures. In contrast, BSP and Phex that are associated with promoting matrix mineralization showed statistically (p ≤ 0.05) higher ~2–4 expression, while FGF23 phosphate regulatory factor was significantly lower (~50%) in mineralizing cultures. Cultures induced to differentiate under both nonmineralizing and mineralizing media conditions showed statistically greater basal oxidative metabolism and ATP production. Maximal respiration and spare oxidative capacity were significantly elevated (p ≤ 0.05) in differentiated nonmineralizing cultures compared to those that mineralized. Increased oxidative metabolism was associated with both an increase in mitochondria volume per cell and mitochondria fusion, while mineralization diminished mitochondrial volume and appeared to be associated with fission. Undifferentiated and mineralized cells showed increased mitochondrial co‐localization with the actin cytoskeletal. Examination of proteins associated with mitochondria fission and apoptosis and mitophagy, respectively, showed levels of immunological expression consistent with the increasing fission and apoptosis in mineralizing cultures. These results suggest that chondrocyte differentiation is associated with intracellular structural reorganization, promoting increased mitochondria content and fusion that enables increased oxidative metabolism. Mineralization, however, does not need energy derived from oxidative metabolism; rather, during mineralization, mitochondria appear to undergo fission and mitophagy. In summary, these studies show that as chondrocytes underwent hypertrophic differentiation, they increased oxidative metabolism, but as mineralization proceeds, metabolism decreased. Mitochondria structure also underwent a structural reorganization that was further supportive of their oxidative capacity as the chondrocytes progressed through their differentiation. Thus, the mitochondria first underwent fusion to support increased oxidative metabolism, then underwent fission during mineralization, facilitating their programed death.
Future exposure of rainfall and temperature extremes to the most populous island of Indonesia: A projection based on CORDEX simulation
Authors: Hendrawan Vempi Satriya Adi , Mawandha Hanggar Ganara , Sakti Anjar Dimara , Karlina  , Andika Neil , Shahid Shamsuddin , Jayadi Rachmad 
Published: June 2024

AbstractThe study focuses on understanding the future exposure to rainfall and temperature extremes in one of the world's most populous islands, Java, Indonesia. We use the high‐resolution climate projections from the Coordinated Regional Climate Downscaling Experiment (CORDEX) simulation for Southeast Asia by 2100 under RCP4.5 and RCP8.5 scenarios. Results show that the island will likely experience drying in the lowlands due to annual rainfall decline by approximately 13%–18%, potentially exposing around 27%–73% of the population (varying under different scenarios) during the end of the century (2060–2099). Additionally, the future drying condition may be exacerbated by extreme temperatures with a 1.7–3.1°C increase in maximum daily temperature, linked with more than half of the population (63%) likely to experience at least an unprecedented temperature of 3°C under RCP8.5. Our seasonal analysis also suggests that dry seasons get even drier, and wet seasons get wetter. In terms of landuse areas exposed, we show a higher fraction of crop and forest areas may face both drying and warming, which can potentially lead to crop failure and wildfire. Our study indicates that compound drought and heat may be a common threat in lowland Java in the future, while intensifying rainfall extremes in the uplands may lead to flash flooding downstream and landslides. These findings highlight the urgent need for adaptation and mitigation strategies to reduce the risks associated with climate change in Java as one of Indonesia's most critical regions in the future.
Growth and development of epiglottis and preepiglottic space of larynx as it acquires vocal tract
Authors: Sato Kiminori , Chitose Shun‐ichi , Sato Kiminobu , Sato Fumihiko , Ono Takeharu , Umeno Hirohito 
Published: June 2024

AbstractObjectivesThe growth and development of the epiglottis and preepiglottic space (PES) of the human larynx as it acquires the vocal tract were investigated.MethodsThree newborns, one infant, four children (2, 7, 8, and 12 years old), and two adult normal larynges were investigated and compared using the whole organ serial section technique.ResultsThe newborn PES occupied a small area just anterior to the epiglottis. It was composed of immature adipose tissue and areolar tissue. The epiglottis lay on a somewhat horizontal axis and is partially obscured behind the hyoid bone. The hyoid bone overlapped the thyroid cartilage, partially obscuring the superior thyroid notch. The newborn epiglottic cartilage was immature elastic cartilage, and the elastic fiber component was sparse. In the first 8 years of life, as the PES grew, the PES was located not only anterior to but also posterolateral and inferolateral to the epiglottic cartilage and thyroepiglottic ligament. Meanwhile, the epiglottic cartilage matured.ConclusionsIn order to develop the vocal tract for speech production, it is reported that the human larynx descends as the child grows in the first 9 years of life. This study showed that the PES, occupying a small area just anterior to the epiglottis, grew and existed astride the epiglottis as the larynx descended and the vocal tract developed. Consequently, its distribution allows the epiglottis to more effectively play the role of retroflection during swallowing in order to prevent aspiration. The human speech faculty likely develops in conjunction with swallowing physiology.
Atypical BCR‐ABL1 transcript in mixed phenotype acute leukemia with bone marrow necrosis
Authors: Liu Jiarui , Jiang Yujie , Yuan Dai , Zhang Zhifen , Liu Xin , Zhao Wenbo , Xu Hongzhi 
Published: June 2024

AbstractMixed phenotype acute leukemia (MPAL) is a type of acute leukemia in which encompasses mixed features of myeloid, T‐lymphoid, and/or B‐lymphoid differentiation. Philadelphia chromosome‐positive (Ph+) MPAL is a rare subgroup with a poor prognosis and accounts for ＜1% of adult acute leukemia. Until now, there is still no consensus on how to best treat Ph+ MPAL. Here, we report a 62‐year‐old male with Ph+ (atypical e13a2 BCR‐ABL1 fusion protein) MPAL. This patient presented with recurrent and intense bone pain due to bone marrow necrosis (BMN). Besides, he did not achieve a complete remission for the first two chemotherapies, until he received flumatinib combined with hyper‐CVAD (B) (a dose‐intensive regimen include methotrexate and cytarabine). To our knowledge, this is the first report to describe the coexistence of BMN and atypical e13a2 BCR‐ABL1 transcripts in patients with MPAL. This finding will bring new understandings in the diagnosis and treatment of Ph+ MPAL.
Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report
Authors: Arakawa Naoko , Shiota Yuno , Onizawa Fumi , Miyata Fumi , Miyoshi Azusa , Akaba Tomohiro , Tsuji Mayoko , Arimura Ken , Yagi Osamitsu , Kondo Mitsuko , Katsura Hideki , Tagaya Etsuko 
Published: June 2024

AbstractA 46‐year‐old male was treated with corticosteroids for nonspecific interstitial pneumonia (NSIP). He was referred to our hospital and admitted for worsening dyspnea and diffuse ground‐glass opacity on chest computed tomography (CT) during corticosteroid treatment. Gottron's sign was observed, and the patient was diagnosed with clinically amyopathic dermatomyositis on skin biopsy. We increased the corticosteroid dose and added immunosuppressive agents; however, the opacity on the chest CT worsened. Based on periodic‐acid‐Schiff‐positive granular material in the bronchoalveolar lavage fluid and the presence of anti‐GM‐CSF antibodies, the patient was diagnosed with autoimmune pulmonary alveolar proteinosis (APAP). The concentration of anti‐GM‐CSF antibodies in preserved serum was also elevated when the patient was diagnosed with NSIP. Thus, we assumed that NSIP and APAP coexisted, and that APAP manifested during immunosuppressive therapy. When exacerbation is observed during the treatment of interstitial pneumonia with immunosuppressive agents, it is necessary to consider APAP.
A ciliated adenocarcinoma of the lung mimicking lung abscess and pneumonia
Authors: Fujimoto Naoki , Fujita Kohei , Ishida Ayami , Moriyoshi Koki , Tanizawa Kiminobu 
Published: June 2024

AbstractThis case report describes a 78‐year‐old man initially treated for pneumonia and lung abscess who was resistant to antimicrobial treatment and was eventually diagnosed with ciliated adenocarcinoma. Ciliated adenocarcinoma, a rare non‐terminal respiratory unit (TRU)‐type lung adenocarcinoma, presents a unique diagnostic challenge because of its similarity to pneumonia and lung abscesses. Morphologically, the ciliated adenocarcinoma in this case appeared to be a non‐TRU type adenocarcinoma, with partial mucous epithelium, no visible extracellular mucus, thyroid transcription factor (TTF)‐1 negativity, and mucin (MUC) 5AC positivity on immunostaining. The patient was considered to have ciliated adenocarcinoma based on the fact that the mucous epithelium was partial and extracellular mucus was not prominent. This case emphasizes the importance of considering malignancy in patients with non‐resolving pulmonary infections.
A new real‐time path planning for USV based on dynamic artificial potential field in complex environments
Authors: Lu Nan , Liu Hao , Wang Yueying , Yan Huaicheng 
Published: June 2024

AbstractThis article studies the problem of real‐time path planning for unmanned surface vessels (USVs) in complex environments. Although this problem has received increasing research attention recently, it is still unsolved to a large extent due to the complexity of obstacles and their high dynamics. In particular, the existing path planning approaches are only able to solve the simplest scenarios. The main contribution of this article is to propose a new dynamic artificial potential field to represent the influence of obstacles on the danger degree of the surrounding environment, which is an important step towards the uniform and appropriate description of dynamic and static obstacles in real‐time path planning. At the same time, based on state constraints of USV, the obstacle avoidance strategy consistent with the International Regulations for Preventing Collisions at Sea (COLREGs, short for Collision Regulations) is set up, and the optimal path is solved by genetic algorithm. Simulation results are presented to verify the effectiveness of the proposed method.