bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physiologically‐based pharmacokinetic modeling predicts the drug interaction potential of GLS4 in co‐administered with ritonavir
Authors: Sun Zexu , Zhao Nan , Xie Ran , Jia Bo , Xu Junyu , Luo Lin , Zhuang Yulei , Peng Yuyu , Liu Xinchang , Zhang Yingjun , Zhao Xia , Liu Zhaoqian , Cui Yimin 
Published: June 2024

AbstractGLS4 is a first‐in‐class hepatitis B virus (HBV) capsid assembly modulator (class I) that is co‐administered with ritonavir to maintain the anticipated concentration required for the effective antiviral activity of GLS4. In this study, the first physiologically‐based pharmacokinetic (PBPK) model for GLS4/ritonavir was successfully developed. The predictive performance of the PBPK model was verified using data from 39 clinical studies, including single‐dose, multiple‐dose, food effects, and drug–drug interactions (DDI). The PBPK model accurately described the PK profiles of GLS4 and ritonavir, with predicted values closely aligning with observed data. Based on the verified GLS4/ritonavir model, it prospectively predicts the effect of hepatic impairment (HI) and DDI on its pharmacokinetics (PK). Notably, CYP3A4 inducers significantly influenced GLS4 exposure when co‐administered with ritonavir; co‐administered GLS4 and ritonavir significantly influenced the exposure of CYP3A4 substrates. Additionally, with the severity of HI increased, there was a corresponding increase in the exposure to GLS4 when co‐administered with ritonavir. The GLS4/ritonavir PBPK model can potentially be used as an alternative to clinical studies or guide the design of clinical trial protocols.
Co‐administration of sub‐effective doses of the constituents of Crocus sativus L. crocins with those of the antipsychotics clozapine and risperidone counteract memory deficits caused by blockade of the NMDA receptor in rats
Authors: Vartzoka Foteini , Parlantza Maria Anastasia , Tarantilis Petros A. , Pitsikas Nikolaos 
Published: June 2024

AbstractExperimental evidence indicates that the noncompetitive N‐methyl‐D‐aspartate (NMDA) receptor antagonists ketamine and MK‐801 induce schizophrenia‐like symptoms in rodents, including cognitive deficits. Crocins are among the active components of the plant Crocus sativus L. and were found to be effective in different models of psychiatric disorders comprising schizophrenia. The present study was designed to evaluate the efficacy of the joint administration of sub‐effective doses of crocins with those of the atypical antipsychotics clozapine and risperidone in alleviating nonspatial recognition and emotional memory deficits induced either by ketamine (3 mg/kg) or MK‐801 (0.1 mg/kg) in the rat. To this end, the object recognition and the step‐through passive avoidance tests were used. Co‐administration of sub‐effective doses of crocins (5 mg/kg) with those of clozapine (0.1 mg/kg) or risperidone (0.03 mg/kg) counteracted nonspatial recognition and emotional memory deficits induced by NMDA receptor antagonists. The current findings suggest that this combinatorial treatment was efficacious in attenuating cognitive impairments related to the blockade of the NMDA receptor. In addition, the present results support the potential of crocins as an adjunctive drug for the therapy of schizophrenia.
Navigating the path to human well‐being amidst climate change in Asian countries
Authors: Pickson Robert Becker , Gui Peng , Asante Grace Nkansa , Tuffour Joseph Kwadwo 
Published: June 2024

AbstractThis study advances the United Nations Sustainable Development Goals, specifically focusing on Goal 3 (Good Health and Well‐Being) and Goal 13 (Climate Action). This study uses novel analytical techniques that consider cross‐sectional dependencies, intra‐cluster correlation, endogeneity, and parameter heterogeneity to explore the relationship between climate change and human well‐being in Asian countries from 1990Q1 to 2019Q4. Our empirical results show three things. First, an inverse relationship exists between temperature and human well‐being in Asian countries. Second, we observe a robust positive impact of rainfall on human well‐being in Asian countries. Lastly, there is a one‐way causal effect from rainfall to human well‐being and a two‐way causal relationship between temperature and human well‐being. Our robust results, therefore, suggest that developing comprehensive economic plans to promote public welfare can create a positive feedback loop where enhanced well‐being drives greater economic engagement and prosperity.
Multiple Glomus Tumours: Clinical, Ultrasonographic and Histopathologic Findings of a Rare Disease
Authors: Wiese Bárbara , Acevedo Patricia F. , Franceschett Rodrigo A. , Riedel Leila , Issa Maria Cláudia A. 
Published: June 2024

Abstract
Glomus tumour is a rare benign neoplasm originating from the glomus body, clinically presenting as a violet-coloured, painful nodule more sensitive when exposed to cold or hot. This hamartoma is typically solitary and predominantly affects the limbs, extremities and nail beds. The appearance of multiple tumours and lesions not placed in the extremities is rare and frequently misdiagnosed. At dermoscopy, it appears as a homogeneous, structureless, purplish area surrounded by a whitish region. Skin ultrasound shows a well-defined, round, hypoechoic mass. We report a case of numerous blue-purplish painful nodules distributed in the trunk and arms while sparing the extremities, with typical dermoscopy and ultrasound findings. A biopsy was performed, confirming the diagnosis of glomangioma. We call attention to this rare condition to help dermatologists make this diagnosis when facing multiple painful nodules.
Biomimetic Gold Nanorods‐Manganese Porphyrins with Surface‐Enhanced Raman Scattering Effect for Photoacoustic Imaging‐Guided Photothermal/Photodynamic Therapy
Authors: Liu Huihui , Gao Cunji , Xu Peijing , Li Yingshu , Yan Xiaoxiao , Guo Xiaolu , Wen Changchun , Shen Xing‐Can 
Published: June 2024

AbstractSurface‐enhanced Raman scattering (SERS) imaging integrating photothermal and photodynamic therapy (PTT/PDT) is a promising approach for achieving accurate diagnosis and effective treatment of cancers. However, most available Raman reporters show multiple signals in the fingerprint region, which overlap with background signals from cellular biomolecules. Herein, a 4T1 cell membrane‐enveloped gold nanorods‐manganese porphyrins system (GMCMs) is designed and successfully fabricated as a biomimetic theranostic nanoplatform. Manganese porphyrins are adsorbed on the surface of Au nanorods via the terminal alkynyl group. Cell membrane encapsulation protects the manganese porphyrins from falling off the gold nanorods. The biomimetic GMCMs confirm specific homologous targeting to 4T1 cells with good dispersibility, excellent photoacoustic (PA) imaging properties, and preferable photothermal and 1O2 generation performance. GMCMs exhibit distinct SERS signals in the silent region without endogenous biomolecule interference both in vitro and in vivo. Manganese ions could not only quench the fluorescence of porphyrins to enhance the SERS imaging effect but also deplete cellular GSH to increase 1O2 yield. Both in vitro and in vivo studies demonstrate that GMCMs effectively eradicate tumors through SERS/PA imaging‐guided PTT/PDT. This study provides a feasible strategy for augmenting the Raman imaging effects of the alkynyl group and integrating GSH‐depletion to enhance PTT/PDT efficacy.
A Metal–Phenolic Network‐Enabled Nanoadjuvant to Modulate Immune Responses
Authors: Wang Zhaoran , Cortez‐Jugo Christina , Yang Yang , Chen Jingqu , Wang Tianzheng , De Rose Robert , Cui Jiwei , Caruso Frank 
Published: June 2024

AbstractThe presence of hierarchical suppressive pathways in the immune system combined with poor delivery efficiencies of adjuvants and antigens to antigen‐presenting cells are major challenges in developing advanced vaccines. The present study reports a nanoadjuvant constructed using aluminosilicate nanoparticles (as particle templates), incorporating cytosine–phosphate–guanosine (CpG) oligonucleotides and small‐interfering RNA (siRNA) to counteract immune suppression in antigen‐presenting cells. Furthermore, the application of a metal–phenolic network (MPN) coating, which can endow the nanoparticles with protective and bioadhesive properties, is assessed with regard to the stability and immune function of the resulting nanoadjuvant in vitro and in vivo. Combining the adjuvanticity of aluminum and CpG with RNA interference and MPN coating results in a nanoadjuvant that exhibits greater accumulation in lymph nodes and elicits improved maturation of dendritic cells in comparison to a formulation without siRNA or MPN, and with no observable organ toxicity. The incorporation of a model antigen, ovalbumin, within the MPN coating demonstrates the capacity of MPNs to load functional biomolecules as well as the ability of the nanoadjuvant to trigger enhanced antigen‐specific responses. The present template‐assisted fabrication strategy for engineering nanoadjuvants holds promise in the design of delivery systems for disease prevention, as well as therapeutics.
Interactive Deformable Colored Sound Display Achieved with Electrostrictive Fluoropolymer and Halide Perovskite
Authors: Park Doowon , Kim Woongji , Park Chaeyong , Choi Jun , Ghorai Arup , Lee Gilwoon , Choi Seungmoon , Moon Wonkyu , Jeong Unyong 
Published: June 2024

AbstractThe association of color and sound helps human cognition through a synergetic effect like intersensory facilitation. Although soft human‐machine interfaces (HMIs) providing unisensory expression have been widely developed, achieving synchronized optic and acoustic expression in one device system has been relatively less explored. It is because their operating principles are different in terms of materials, and implementation has mainly been attempted through structural approaches. Here, a deformable sound display is developed that generates multiple colored lights with large sound at low input voltage. The device is based on alternating‐current electroluminescence (ACEL) covered with perovskite composite films. A sound wave is created by a polymer matrix of the ACEL, while simultaneously, various colors are produced by the perovskite films and the blue electroluminescence (EL) emitted from the phosphors in the ACEL. By patterning different colored perovskite films onto the ACELs, associating the color and the sound is successfully demonstrated by a piano keyboard and a wearable interactive device.
Electrochemical Synthesis of Urea: Co‐Reduction of Nitrite and Carbon Dioxide on Binuclear Cobalt Phthalocyanine
Authors: Zhang Rui , Hu Wenhui , Liu Jingjing , Xu Kaidi , Liu Yi , Yao Yahong , Liu Minmin , Zhang Xia‐Guang , Li Hong , He Peng , Huo Shengjuan 
Published: June 2024

AbstractExploration of molecular catalysts with the atomic‐level tunability of molecular structures offers promising avenues for developing high‐performance catalysts for the electrochemical co‐reduction reaction of carbon dioxide (CO2) and nitrite (NO2−) into value‐added urea. In this work, a binuclear cobalt phthalocyanine (biCoPc) catalyst is prepared through chemical synthesis and applied as a C─N coupling catalyst toward urea. Achieving a remarkable Faradaic efficiency of 47.4% for urea production at –0.5 V versus reversible hydrogen electrode (RHE), this biCoPc outperforms many known molecular catalysts in this specific application. Its unique planar macromolecular structure and the increased valence state of cobalt promote the adsorption of nitrogenous and carbonaceous species, a critical factor in facilitating the multi‐electron C─N coupling. Combining highly sensitive in situ attenuated total reflection surface‐enhanced infrared absorption spectroscopy (ATR‐SEIRAS) with density functional theory (DFT) calculations, the linear adsorbed CO (COL) and bridge adsorbed CO (COB) is captured on biCoPc catalyst during the co‐reduction reaction. COB, a pivotal intermediate in the co‐reduction from CO2 and nitrite to urea, is evidenced to be labile and may be attacked by nitrite, promoting urea production. This work demonstrates the importance of designing molecular catalysts for efficient co‐reduction of CO2 and nitrite to urea.
Robust and Lubricating Interface Semi‐Interpenetrating Network on Inert Polymer Substrates Enabled by Subsurface‐Initiated Polymerization
Authors: Tang Jie , Zhang Yunlei , Qi Changmin , Li Bin , Wu Yang , Ma Shuanhong , Ma Yanfei , Yu Qiangliang , Yang Wufang , Xi Pinxian , Yu Bo , Zhou Feng 
Published: June 2024

AbstractLubricating hydrogel coatings on inert rubber and plastic surfaces significantly reduce friction and wear, thus enhancing material durability and lifespan. However, achieving optimal hydration lubrication typically requires a porous polymer network, which unfortunately reduces their mechanical strength and limits their applicability where robust durability and wear‐resistance are essential. In the research, a hydrogel coating with remarkable wear resistance and surface stability is developed by forming a semi‐interpenetrating polymer network with polymer substrate at the interface. By employing a good solvent swelling method, monomers, and photoinitiators are embedded within the substrates' subsurface, followed by in situ polymerization under ultraviolet light, creating a robust semi‐interpenetrating and entangled network structure. This approach, offering a thicker energy‐dissipating layer, outperforms traditional surface modifications in wear resistance while preserving anti‐fatigue, hydrophilicity, oleophobicity, and other properties. Adaptable to various rubber and plastic substrates by using suitable solvents, this method provides an efficient solution for creating durable, lubricating surfaces, broadening the potential applications in multiple industries.
Enhanced Temperature Stability of Pyroelectric Sensing in Multilayer Potassium Sodium Niobate‐Based Ceramics with Graded Polarization Rotation
Authors: Zhang Yumin , Wen Lanji , Huang Yuntao , Meng Dechao , Zheng Ting , Wu Jiagang 
Published: June 2024

AbstractPyroelectric effect which refers to electrical responses induced by time temperature‐dependent fluctuations has received extensive attention, showing promising application prospects for infrared (IR) technology. Although enhanced pyroelectric performances are obtained in potassium sodium niobate‐based ceramics at room temperature via multi‐symmetries coexistence design, the poor pyroelectric temperature stability is still an urging desire that needs to be resolved. Herin, by constructing multilayer composite ceramics and adjusting the proportion of stacked layers, improved pyroelectric coefficient, and figures of merit (FOMs), as well as enhanced temperature stabilities can be achieved. With a remained high pyroelectric coefficient of 5.45 × 10−4 C m−2°C−1 at room temperature, the pyroelectric parameters almost keep unchanged in the temperature range of 30–100 °C, showing great properties advantages compared with previous reports. The excellent properties can be attributed to the graded polarization rotation states among each lamination induced by successive phase transitions. The novel strategy for achieving stable pyroelectric sensing can further promote the application in the IR sensors field.
Design and Performance of Small‐Molecule Donors with Donor–π‐Acceptor Architecture Toward Vacuum‐Deposited Organic Photovoltaics Having Heretofore Highest Short‐Circuit Current Density
Authors: Chen Bin‐Wen , Cao Kun , Wang Xu , Chen Zuo‐Chang , Jeong Sang Young , Qiu Zhen‐Lin , Dai Le‐Shan , Li Yun‐Fei , Yang Ke‐Yue , Yun Da‐Qin , Woo Han Young , Deng Lin‐Long , Xie Su‐Yuan , Zheng Lan‐Sun 
Published: June 2024

AbstractThe development of high‐performance organic photovoltaic materials is of crucial importance for the commercialization of organic solar cells (OSCs). Herein, two structurally simple donor‐π‐conjugated linker‐acceptor (D‐π‐A)‐configured small‐molecule donors with methyl‐substituted triphenylamine as D unit, 1,1‐dicyanomethylene‐3‐indanone as A unit, and thiophene or furan as π‐conjugated linker, named DTICPT and DTICPF, are developed. DTICPT and DTICPF are facilely prepared via a two‐step synthetic process with simple procedures. DTICPF with a furan π‐conjugated linker exhibits stronger and broader optical absorption, deeper highest occupied molecular orbital (HOMO) energy levels, and better charge transport, compared to its thiophene analog DTICPT. As a result, vacuum‐deposited OSCs based on DTICPF: C70 show an impressive power conversion efficiency (PCE) of 9.36% (certified 9.15%) with short‐circuit current density (Jsc) up to 17.49 mA cm−2 (certified 17.56 mA cm−2), which is the highest Jsc reported so far for vacuum‐deposited OSCs. Besides, devices based on DTICPT: C70 and DTICPF: C70 exhibit excellent long‐term stability under different aging conditions. This work offers important insights into the rational design of D‐π‐A configured small‐molecule donors for high efficient and stable vacuum‐deposited OSCs.
Exploring Phenolphthalein Polyarylethers as High‐Performance Alternative Binders for High‐Voltage Cathodes in Lithium‐Ion Batteries
Authors: Yang Kai , Chen Keding , Zhang Xingdi , Gao Shuyu , Sun Jichang , Gong Jin , Chai Jinchao , Zheng Yun , Liu Zhihong , Wang Honghua 
Published: June 2024

AbstractPolyvinylidene fluoride (PVDF) has unique electrochemical oxidation resistance and is the only binder for high‐voltage cathode materials in the battery industry for a long time. However, PVDF still has some drawbacks, such as environmental limitations on fluorine, strict requirements for environmental humidity, weak adhesion, and poor lithium ion conductivity. Herein, the long‐standing issues associated with high‐voltage lithium cobalt oxide (LiCoO2; LCO) are successfully addressed by incorporating phenolphthalein polyetherketone (PEK‐C) and phenolphthalein polyethersulfone (PES‐C) as binder materials. These binders have unexpected electrochemical oxidation resistance and robustness adhesion, ensure uniform coverage on the surface of LCO, and establish an effective and fast ion‐conductive CEI/binder composite layer. By leveraging these favorable characteristics, electrodes based on polyarylether binders demonstrate significantly better cycling and rate performance than their counterparts using traditional PVDF binders. The fast ion‐conductive CEI/binder composite layer effectively mitigates adverse reactions at the cathode–electrolyte interface. As anticipated, batteries utilizing phenolphthalein polyarylether binders exhibit capacity retention rates of 88.92% and 80.4% after 200 and 500 cycles at 4.5 and 4.6 V, respectively. The application of binders, such as polyarylether binders, offers a straightforward and inspiring approach for designing high‐energy‐density battery materials.
Oral Heterojunction Coupling Interventional Optical Fiber Mediates Synergistic Therapy for Orthotopic Rectal Cancer
Authors: Li Ruiyan , Fu Dianxun , Yuan Xue , Niu Gaoli , Fan Yueyue , Shi Jiacheng , Yang Yiwen , Ye Jiamin , Han Jingwen , Kang Yong , Ji Xiaoyuan 
Published: June 2024

AbstractCatalytic therapy has shown great potential for clinical application. However, conventional catalytic therapies rely on reactive oxygen species (ROS) as “therapeutic drugs,” which have limitations in effectively inhibiting tumor recurrence and metastasis. Here, a biomimetic heterojunction catalyst is developed that can actively target orthotopic rectal cancer after oral administration. The heterojunction catalyst is composed of quatrefoil star‐shaped BiVO4 (BVO) and ZnIn2S4 (ZIS) nanosheets through an in situ direct growth technique. Poly‐norepinephrine and macrophage membrane coatings afford the biomimetic heterojunction catalyst (BVO/ZIS@M), which has high rectal cancer targeting and retention abilities. The coupled optical fiber intervention technology activates the multicenter coordination of five catalytic reactions of heterojunction catalysts, including two reduction reactions (O2→·O2− and CO2→CO) and three oxidation reactions (H2O→·OH, GSH→GSSG, and LA→PA). These catalytic reactions not only induce immunogenic death in tumor cells through the efficient generation of ROS/CO and the consumption of GSH but also specifically lead to the use of lactic acid (LA) as an electron donor to improve catalytic activity and disrupt the LA‐mediated immunosuppressive microenvironment, mediating synergistic catalysis and immunotherapy for orthotopic rectal cancer. Therefore, this optical fiber intervention triggered the combination of heterojunction catalytic therapy and immunotherapy, which exhibits prominent antitumor effects.
Atmospheric Pressure Alkaline Etching of MFI Zeolite Under Mild Temperature Toward Hollow Microstructure and Ultralow k Film
Authors: Zhang Kaipeng , Xu Ruilan , Wang Rui , Cai Junhui , Lin Xintu , Gan Lu , Wang Zhengbao , Peng Yong 
Published: June 2024

AbstractConstructing a hollow structure inside zeolite is very helpful for improving its performance. Unlike the conventional alkaline etching technique usually operated at high temperature (typically 170 °C) and high pressure (autogenerated in autoclave), here, it is discovered that zeolite MFI nano‐box can be achieved under mild etching conditions of atmospheric pressure and low temperature of 80 °C, making it very attractive for energy conservation and practical applications. A hollow‐structure formation mechanism of protection‐dissolution etching is demonstrated by characterizing MFI crystals obtained under different etching time, temperature, and etchant concentration. The utilization of template agent‐free secondary growth leads to the successful fabrication of a continuous b‐oriented hierarchical MFI zeolite film with desired microstructure of embedded cavities and opened pores. The advantage of the newly constructed film is highlighted by its ultralow k value accompanied with high mechanical strength.
Hearing loss and cognitive decline: Prioritizing equity in a world in which hearing health matters
Authors: Nieman Carrie L. , Thorpe Roland J. , Oh Esther S. 
Published: June 2024

AbstractAlzheimer's disease and related dementias (ADRDs) and age‐related hearing loss are the intersection of two major public health challenges. With age as the primary risk factor for both disease processes, the burden of ADRDs and age‐related hearing loss is growing, and each field maintains significant barriers to broadscale identification and management that is affordable and accessible. With the disproportionate burden of ADRDs among racial and ethnic minority older adults and existing disparities within hearing care, both areas face challenges in achieving equitable access and outcomes across diverse populations. The publication of the Aging and Cognitive Health Evaluation in Elders (ACHIEVE) trial in July 2023 marked a significant moment in the fields of brain and hearing health. The ACHIEVE trial was the first randomized controlled trial to examine whether providing hearing intervention, specifically provision of hearing aids, compared to an education control, would reduce cognitive changes over 3 years. The participants most at risk for cognitive decline, with lower education, lower income, more likely to identify as Black, and have more cardiovascular risk factors, were the participants who benefited most from the hearing intervention and are also the least likely to be represented in research and the least likely to obtain hearing care. With growing evidence of the interconnection between cognitive and sensory health, we have an opportunity to prioritize equity, from purposeful inclusion of diverse participants in trials to influencing the emerging market of over‐the‐counter hearing aids to supporting expanded models of hearing care that reach those who have traditionally gone unserved. No longer can hearing go unrecognized by clinicians, researchers, and advocates for brain health. At the same time, the fields of brain and hearing health must center equity if we are going to meet the needs of diverse older adults in a world in which hearing health matters.