bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competition between biodetoxification fungus and lactic acid bacterium in the biorefinery processing chain for production of cellulosic L-lactic acid
Authors: Li Zhibin , Zhang Lingxiao , He Niling , Zhang Bin , Bao Jie 
Published: May 2024

AbstractBiodetoxification fungus selectively degrades toxic inhibitors generated from pretreatment of lignocellulose without consuming fermentable sugars. However, one barrier for practical application is the sustained cell viability in the consequent fermentation step to compete the fermentable sugars with fermenting strains, resulting in sugar loss and reduced target product yield. This study investigated the competitive growth property between the biodetoxification fungus Paecilomyces variotii FN89 and the L-lactic acid bacterium Pediococcus acidilactici ZY271 under varying temperature and lactic acid osmatic stress. The results show that the L-lactic acid bacterium Ped. acidilactici ZY271 showed less thermotolerance to Pae. variotii FN89 at high temperature of 45 °C to 50 °C in both synthetic medium and wheat straw hydrolysate. In the higher temperature environment, the growth of the biodetoxification strian failed to compete with the lactic acid fermentation strain and was quickly eliminated from the fermentation system. The high temperature fermentation facilitated a fast transition from the detoxification stage to the fermentation stage for higher production of L-lactic acid.
Near vision in patients with DME and RVO treated with aflibercept and correlation with NEI VFQ-25 questionnaire
Authors: Sulavikova Zuzana Anwarzai , Sustykevicova Zuzana , Kacerik Marek , Krasnik Vladimir 
Published: May 2024

Abstract
Background
The aim of this study is to evaluate near and distance visual acuity (VA) and their correlation with the National Eye Institute Visual Function Questionnaire (NEI VFQ-25) outcomes in patients with diabetic macular edema (DME) and macular edema due to retinal vein occlusion (RVO) treated with aflibercept.

Methods
In this prospective study, we included 87 eyes of patients diagnosed with DME (n = 61) and RVO (n = 26), who received aflibercept treatment and were followed until the 8th injection. Near VA was examined on the 1st, 2nd, 3rd, 4th, 6th, and 8th injection, and patients completed the NEI VFQ-25 on the 1st, 4th, and 8th aflibercept injection.

Results
The mean near VA at baseline in all eyes was 0.89 ± 0.12 logMAR. With every administration, there was a statistically significant improvement; on the 4th (0.70 ± 0.19; p = 0.000) and the 8th application (0.60 ± 0.19; p = 0.000). At baseline, the mean NEI VFQ-25 total score was 71 ± 14%, and improved to 81 ± 13% (p = 0.000) on the 8th injection. The most significant score gain was recorded in the near VA subscale (+ 20 ± 14%, p = 0.000). There was no statistically significant difference between DME and RVO group in the questionnaire or near VA outcomes.

Conclusion
Aflibercept treatment resulted in a remarkable improvement of near vision by 4 lines of logMAR optotype after the 8th application. The near vision questionnaire subscale, initially scoring the lowest, exhibited the greatest gain during the treatment period. This underscores the importance of near vision and reading ability for patients with DME and RVO.
A scoping review on how generative artificial intelligence transforms assessment in higher education
Authors: Xia Qi , Weng Xiaojing , Ouyang Fan , Lin Tzung Jin , Chiu Thomas K.F. 
Published: May 2024

AbstractGenerative artificial intelligence provides both opportunities and challenges for higher education. Existing literature has not properly investigated how this technology would impact assessment in higher education. This scoping review took a forward-thinking approach to investigate how generative artificial intelligence transforms assessment in higher education. We used the PRISMA extension for scoping reviews to select articles for review and report the results. In the screening, we retrieved 969 articles and selected 32 empirical studies for analysis. Most of the articles were published in 2023. We used three levels—students, teachers, and institutions—to analyses the articles. Our results suggested that assessment should be transformed to cultivate students’ self-regulated learning skills, responsible learning, and integrity. To successfully transform assessment in higher education, the review suggested that (i) teacher professional development activities for assessment, AI, and digital literacy should be provided, (ii) teachers’ beliefs about human and AI assessment should be strengthened, and (iii) teachers should be innovative and holistic in their teaching to reflect the assessment transformation. Educational institutions are recommended to review and rethink their assessment policies, as well as provide more inter-disciplinary programs and teaching.
The outcomes and complications of percutaneous interventions in chronic total coronary occlusion
Authors: Suleman Muhammad , Arif Nayyar , Khan Muhammad Ishaq , Jibran Muhammad Saad , Jamil Muhammad , Khan Shafi Ullah , Khan Shah Sawar , Maken Ghulam Rasool 
Published: May 2024

Abstract
Background
The limited availability of complex coronary intervention facilities and qualified operators, due to the high cost associated with chronic total occlusion (CTO) percutaneous intervention (PCI) equipment and a shortage of necessary skills, has led to a scarcity of capable medical centers in Pakistan. This study seeks to examine the outcomes and potential complications associated with CTO PCI procedures conducted at the Cardiac Catheterization Laboratories of a prominent national institute in Pakistan, which handles a large volume of cases.

Results
Three hundred and six patients were included in the study in the study period of six months. The mean age was 59.49 (± 9.16) years: 256 (83.66%) were male and 50 (16.34%) were female. CTO was successfully re-vascularized in 237 (77.5%) with a complication rate of 13.7%. Two hundred and ninety-eight (97.39%) patients underwent an antegrade approach, while RCA was the most common target vessel (47.71%). Diabetes was the only significant associated risk factor with CTO PCI failure (30.43% vs. 30.43%, P-value = 0.015).

Conclusion
We achieved an excellent procedural success rate with a low complication rate. CTO procedural failure is associated with a higher complication rate, and diabetes is among the risk factors that lead to higher procedural failure.
Predictors of suicidal behaviors among school-going adolescents: a cross sectional study in Indonesia
Authors: Kurniawan Dedi , Fitriawan Akbar Satria , Susanti Brigitta Ayu Dwi , Firdaus Insanul , Suparmanto Gatot , Kafil Raisa Farida , Wulandari Apri Nur , Setyaningsih Wiwit Ananda Wahyu , Puspitarini Zenni , Wijoyo Eriyono Budi 
Published: May 2024

Abstract
Background
Adolescents are a high-risk age group for committing suicide, and the risk substantially increases from early to late adolescence. Adolescence also serves as critical time period for early detection and intervention to prevent suicidal behaviors. This study aimed to assess the prevalence of suicidality and identify significant predictors of suicidality among adolescents.

Methods
A cross-sectional observational study was conducted between January-December 2023. Adolescents aged 14–18 years old (n = 2317) were consecutively recruited from 15 high schools across four provinces on Java Island in Indonesia. Self-reported validated instruments in Indonesian were used to assess sociodemographic profiles, self-esteem (RSES), hopelessness (BHS), loneliness (ULS-3), perceived social support (MSPSS), depression (PHQ-9), resilience (CD-RISC-10), suicidality (SBQ-R). With adjusted odds ratio (AOR) and 95% confidence interval (CI), binary logistic regression analysis was used to determine significant predictors of suicidality.

Results
The prevalence of lifetime suicide ideation was 26.5%, lifetime suicide plans were 18.2%, lifetime suicide threat was 14.1%, and lifetime suicide attempt was 4.4%. The prevalence of 12-month suicide ideation was 43.1%. The following variables were identified and significantly associated with suicidality (p < 0.05): female students (AOR = 1.912; 95%CI:1.507–2.425), chronic illness (AOR = 2.886; 95%CI:1.545–5.389), low resilience (AOR = 1.347; 95%CI:1.036–1.750), low self-esteem (AOR = 2.020; 95%CI:1.578–2.585), low family support (AOR = 3.532; 95%CI:2.486–5.017), loneliness (AOR = 1.611; 95%CI:1.211–2.143), depression (AOR = 4.882; 95%CI = 3.861–6.175), and hopelessness (AOR = 1.602; 95%CI:1.154–2.224). Nagelkerke R square was 0.364 indicating the regression model explained 36.4% of variance in suicidality.

Conclusions
Our study revealed several significant predictors of suicidality among adolescents which can be targeted to develop suicide prevention strategies.
Determinants of implementation for group medical visits for patients with chronic pain: a systematic review
Authors: Roth Isabel , Tiedt Malik , Brintz Carrie , Thompson-Lastad Ariana , Ferguson Gayla , Agha Erum , Holcomb Jennifer , Gardiner Paula , Leeman Jennifer 
Published: May 2024

AbstractBackgroundDespite the critical need for comprehensive and effective chronic pain care, delivery of such care remains challenging. Group medical visits (GMVs) offer an innovative and efficient model for providing comprehensive care for patients with chronic pain. The purpose of this systematic review was to identify barriers and facilitators (determinants) to implementing GMVs for adult patients with chronic pain.MethodsThe review included peer-reviewed studies reporting findings on implementation of GMVs for chronic pain, inclusive of all study designs. Pubmed, EMBASE, Web of Science, and Cochrane Library were searched. Studies of individual appointments or group therapy were excluded. The Mixed Methods Appraisal Tool was used to determine risk of bias. Data related to implementation determinants were extracted independently by two reviewers. Data synthesis was guided by the updated Consolidated Framework for Implementation Research.ResultsThirty-three articles reporting on 25 studies met criteria for inclusion and included qualitative observational (n = 8), randomized controlled trial (n = 6), quantitative non-randomized (n = 9), quantitative descriptive (n = 3), and mixed methods designs (n = 7). The studies included in this review included a total of 2364 participants. Quality ratings were mixed, with qualitative articles receiving the highest quality ratings. Common multi-level determinants included the relative advantage of GMVs for chronic pain over other available models, the capability and motivation of clinicians, the cost of GMVs to patients and the health system, the need and opportunity of patients, the availability of resources and relational connections supporting recruitment and referral to GMVs within the clinic setting, and financing and policies within the outer setting.ConclusionsMulti-level factors determine the implementation of GMVs for chronic pain. Future research is needed to investigate these determinants more thoroughly and to develop and test implementation strategies addressing these determinants to promote the scale-up of GMVs for patients with chronic pain.Trial registrationThis systematic review was registered with PROSPERO 2021CRD42021231310.
Exploring the antimicrobial activity of Origanum majorana L. against the highly virulent multidrug-resistant Acinetobacter baumannii AB5075: UPLC-HRMS profiling with in vitro and in silico studies
Authors: Mahdally Norhan H. , Salih Abdalla E. M. , El-Shiekh Riham A. , Sayed Ahmed M. , Elhosseiny Noha M. , Kashef Mona T. , Yaseen Mohammed , Mackay William , El Halawany Ali M. , Rateb Mostafa E. , Attia Ahmed S. 
Published: May 2024

Abstract
Background
The infamous multidrug-resistant (MDR) bacterium Acinetobacter baumannii is becoming a nightmare in intensive care units across the globe. Since there are now very few effective antimicrobial agents, it is necessary to explore unconventional resources for novel antimicrobials. This study investigated the potential antimicrobial activity of Origanum majorana L. against A. baumannii employing multiple approaches including antimicrobial susceptibility, fractionation, ultra-performance liquid chromatography–high-resolution mass spectrometry (UPLC-HRMS) dereplication, and in silico analysis for target/ligand identification.

Results
On the extremely pathogenic MDR strain A. baumannii AB5075, O. majorana L. has shown a significant growth inhibitory effect (MIC = 0.675 mg/mL). The polar 50% methanol fraction was the most active (MIC = 0.5 mg/mL). The UPLC-HRMS dereplication of the bioactive fraction detected 29 metabolites belonging to different chemical classes. Justicidin B, one of the identified metabolites, was projected by preliminary in silico analysis to be the most highly scoring metabolite for binding with molecular targets in A. baumannii with a Fit score = 8.56 for enoyl-ACP reductase (FabI) (PDB ID: 6AHE), suggesting it to be its potential target. Additionally, docking, molecular dynamics simulation, and bioinformatics analysis suggested that this interaction is similar to a well-known FabI inhibitor. The amino acids involved in the interaction are conserved among different MDR A. baumannii strains and the effectiveness could extend to Gram-negative pathogens within the ESKAPE group.

Conclusions
Origanum majorana L. extract exhibits antimicrobial activity against A. baumannii using one or more metabolites in its 50% methanol fraction. The characterized active metabolite is hypothesized to be justicidin B which inhibits the growth of A. baumannii AB5075 via targeting its fatty acid synthesis.
Evaluating the efficacy of a novel periosteal flap in cochlear implantation: a retrospective surgical audit at a tertiary teaching hospital
Authors: Kothandaraman Kirubakaran , Panda Naresh K. , Patro Sourabha K. 
Published: May 2024

Abstract
Background
This research aimed to critically evaluate the safety and reliability of a new periosteal flap technique in cochlear implantation through a comprehensive surgical audit. A surgical audit was conducted on a cohort of 39 patients who underwent cochlear implantation at a tertiary teaching hospital from July 2020 to September 2021. The novel periosteal flap technique was utilized in all cases. Patients were followed up for a period ranging from 2 to 12 months. For comparison, outcomes were assessed by comparing 51 children who had undergone cochlear implant surgery between July 2017 and June 2019, utilizing the anteriorly based palva flap. A scoring system was employed to evaluate various aspects, including ease of surgical exposure, flap maneuverability, ease of closure after device fixation, immediate postoperative complications (up to 24 h), and delayed complications (up to 30 days). Scores ranging from 1 (fair assessment) to 4 (excellent assessment) were assigned, with a maximum score of 18 indicating optimal outcomes.

Results
The comparison between the two groups revealed a reduced incidence of emissary vein injury and easier wound closure after device fixation in the novel periosteal flap group (p = 0.000). The mean total scores were significantly higher in the novel periosteal flap group, indicating superior outcomes. Only 2 out of 39 children with the novel flap experienced minor skin color changes during the initial postoperative period, which resolved within approximately 7 days. Major complications such as wound infection, hematoma, or device migration were not observed with the new periosteal flap. Furthermore, no flap revisions were required.

Conclusions
The novel and innovative periosteal flap demonstrated both safety and reliability in cochlear implantation procedures. This well-vascularized and robust flap offered effective device coverage with minimal flap-related complications. Its time-saving nature further enhances its clinical utility. Additional validation from different medical centers would further corroborate the advantages of this easily implemented periosteal flap technique.

Level of evidence
Level 3.
Climate change and mental health: Position paper of the European Psychiatric Association
Authors: Brandt Lasse , Adorjan Kristina , Catthoor Kirsten , Chkonia Eka , Falkai Peter , Fiorillo Andrea , Gondek Tomasz M. , Le Vay Jessica Newberry , Rojnic Martina , Meyer-Lindenberg Andreas , Heinz Andreas , Dom Geert , Luykx Jurjen J. 
Published: May 2024

Abstract

Background
Climate change is one of the greatest threats to health that societies face and can adversely affect mental health. Given the current lack of a European consensus paper on the interplay between climate change and mental health, we signal a need for a pan-European position paper about this topic, written by stakeholders working in mental health care.

Methods
On behalf of the European Psychiatric Association (EPA), we give recommendations to make mental health care, research, and education more sustainable based on a narrative review of the literature.

Results
Examples of sustainable mental healthcare comprise preventive strategies, interdisciplinary collaborations, evidence-based patient care, addressing social determinants of mental health, maintaining health services during extreme weather events, optimising use of resources, and sustainable facility management. In mental health research, sustainable strategies include investigating the impact of climate change on mental health, promoting research on climate change interventions, strengthening the evidence base for mental health-care recommendations, evaluating the allocation of research funding, and establishing evidence-based definitions and clinical approaches for emerging issues such as ‘eco-distress’. Regarding mental health education, planetary health, which refers to human health and how it is intertwined with ecosystems, may be integrated into educational courses.

Conclusions
The EPA is committed to combat climate change as the latter poses a threat to the future of mental health care. The current EPA position paper on climate change and mental health may be of interest to a diverse readership of stakeholders, including clinicians, researchers, educators, patients, and policymakers.
Global Landscape of the Attack of Predatory Journals in Oncology
Authors: El Bairi Khalid , Trapani Dario , Nidhamalddin Sara Jamil , Khan Shah Zeb , Chowdhury Arman Reza , Lengyel Csongor György , Hussain Sadaqat , Habeeb Baker Shalal , Petrillo Angelica , Omar Nabil Elhadi , Altuna Sara , Seid Fahmi Usman , Elfaham Essam , Seeber Andreas , Roitberg Felipe , Burguete-Torres Alan , El Kefi Safa , Hammad Nazik , Mutebi Miriam , Al Jarroudi Ouissam , El Kadmiri Nadia , Curigliano Giuseppe , Afqir Said 
Published: May 2024

PURPOSE Open-access publishing expanded opportunities to give visibility to research results but was accompanied by the proliferation of predatory journals (PJos) that offer expedited publishing but potentially compromise the integrity of research and peer review. To our knowledge, to date, there is no comprehensive global study on the impact of PJos in the field of oncology. MATERIALS AND METHODS A 29 question-based cross-sectional survey was developed to explore knowledge and practices of predatory publishing and analyzed using descriptive statistics and binary logistic regression. RESULTS Four hundred and twenty-six complete responses to the survey were reported. Almost half of the responders reported feeling pressure to publish from supervisors, institutions, and funding and regulatory agencies. The majority of authors were contacted by PJos through email solicitations (67.8%), with fewer using social networks (31%). In total, 13.4% of the responders confirmed past publications on PJo, convinced by fast editorial decision time, low article-processing charges, limited peer review, and for the promise of academic boost in short time. Over half of the participants were not aware of PJo detection tools. We developed a multivariable model to understand the determinants to publish in PJos, showing a significant correlation of practicing oncology in low- and middle-income countries (LMICs) and predatory publishing (odds ratio [OR], 2.02 [95% CI, 1.01 to 4.03]; P = .04). Having previous experience in academic publishing was not protective (OR, 3.81 [95% CI, 1.06 to 13.62]; P = .03). Suggestions for interventions included educational workshops, increasing awareness through social networks, enhanced research funding in LMICs, surveillance by supervisors, and implementation of institutional actions against responsible parties. CONCLUSION The prevalence of predatory publishing poses an alarming problem in the field of oncology, globally. Our survey identified actionable risk factors that may contribute to vulnerability to PJos and inform guidance to enhance research capacity broadly.
Interference With VIP to Distinguish Between Real and False VIPoma: National Study From the French Endocrine Tumors Group
Authors: Chevalier Benjamin , Bonnet Delphine , Lepage Come , Perrier Marine , Borson-Chazot Françoise , Abeillon Juliette , Delobel Jean Bernard , Jannin Arnaud , Hadoux Julien , Haissaguere Magalie , Lombard-Bohas Catherine , Walter Thomas , Chardon Laurence 
Published: May 2024

Abstract

Background
Vasoactive intestinal peptide (VIP)-secreting tumors (VIPomas) are digestive neuroendocrine tumors in which the hormonal secretion is life-threatening. Biological confirmation is obtained by demonstrating an elevation in plasma VIP, usually using radioimmunoassay (RIA). In some cases, analytical interference is suspected. We developed 3 different techniques to detect interference in VIP RIA.

Methods
Three techniques were used: RIA after Sephadex column chromatography separation, RIA after polyethylene glycol precipitation, and 125I-labeled VIP binding test. We included patients with suspicion of false positive VIP (FPV) elevation. We then compared results with those of a group of “real,” proven VIPoma (RV).

Results
A total of 15 patients with FPV elevation and 9 RV patients were included. Interference was detected in all FPV patients vs none in RV. Clinical and biochemical parameters did not differ between FPV and RV patients, but VIP concentration in RIA was significantly higher in FPV patients than in RV patients (228 pmol/L vs 66 pmol/L, P = .038). Using a 125I-labeled VIP binding test, median proportion of radioactivity in the pellet was significantly higher in FPV than in RV patients (53% vs 13%, P &lt; .0001). A 20.5% threshold presented excellent performances (sensitivity 100% [79.6-100], specificity 100% [70.1-100]).

Conclusion
We developed 3 different laboratory techniques to reveal interference in RIA VIP assays. The diagnostic performance of all 3 was excellent. These techniques must be employed in cases of discordance between VIP elevation and clinical presentation.