bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fracture toughness and failure behavior of CF/epoxy composites interleaved with melt‐infused PET, PEI, and PEEK film
Authors: Too Daniel Kipkirui , Kumar Sanjay , Kim Yun‐Hae 
Published: June 2024

AbstractThis study investigates the effect of incorporating polyethylene terephthalate (PET), polyetherimide (PEI), and polyether‐ether‐ketone (PEEK) thermoplastic films in melt form as interlayers to toughen carbon fiber/epoxy composites. The addition of melt‐infused PET, PEI, and PEEK film into carbon fiber/epoxy composite enhanced the mode‐I interlaminar fracture toughness (ILFT) by 60%, 156%, and 284%, respectively. The primary toughening mechanisms found were plastic deformation and mechanical interlocking through fiber bridging, which left fiber imprint traces on the fracture surface. The mode‐II ILFT of PET, PEI, and PEEK film interleaved laminates was improved by 80%, 188%, and 96%, respectively. Plastic deformation was observed to be the principal toughening mechanism. Notably, these enhancements in ILFT were achieved while simultaneously increasing interlaminar shear strength. These findings show the role of hot‐melt‐infused PET, PEI, and PEEK thermoplastic films in the improvement of ILFT of composites which is crucial in the design of damage‐tolerant composite structures.Highlights
Composites were interleaved with PET, PEI, and PEEK films via melt‐infusion.
Mode‐I and mode‐II ILFT were significantly enhanced, up to 284% for PEEK.
Failure exhibited plastic deformation, extensive fiber bridging, and pull‐out.
Melt‐infusion created complex, mechanically interlocked interfaces.
Towards developing advanced CFRP with simultaneously enhanced fracture toughness and in‐plane properties via interleaving CNT/PEI hybrid veils
Authors: Weng Yiting , Liu Kun , Ou Yunfu , Li Juan , Mao Dongsheng 
Published: June 2024

AbstractCarbon nanotube (CNT)‐polyetherimide (PEI) hybrid nanofibrous veils were prepared through the electrospinning process to function as an interlayer in carbon fiber reinforced polymer composites (CFRP), and the effects of the addition of the hybrid fiber veils on the interlaminar fracture properties and flexural properties of CFRP were investigated. The results showed that interleaving CNT/PEI hybrid veils can effectively avoid long‐troubled trade‐off between mode‐I interlaminar fracture toughness and in‐plane properties when using thermoplastic toughening materials. Specifically, the GIc value and flexural strength of the laminates were increased by as much as 86.2% and 14.3%, respectively when CNT content was reached up to 0.7 wt% in CNT/PEI hybrid veil. This method adopts ultra‐low PEI and CNT additions, and the limited quantity of these additives demonstrates a notably high interlaminar toughening efficiency while concurrently enhancing the strength, rendering it a promising strategy for both toughening and strengthening.Highlights
PEI is used as a carrier to transport CNT to the CFRP interlaminar layers.
PEI‐CNT hybrid fiber veils improve GIC and flexural strength of CFRP.
PEI‐CNT hybrid fiber veils impede crack expansion through various mechanisms.
This method adopts ultra‐low PEI and CNT additions.
Progress in the analysis of phytocannabinoids by HPLC and UPLC (or UHPLC) during 2020–2023
Authors: Nahar Lutfun , Chaiwut Phanuphong , Sangthong Sarita , Theansungnoen Tinnakorn , Sarker Satyajit D. 
Published: June 2024

AbstractIntroductionOrganic molecules that bind to cannabinoid receptors are known as cannabinoids. These molecules possess pharmacological properties similar to those produced by Cannabis sativa L. High‐performance liquid chromatography (HPLC) and ultra‐performance liquid chromatography (UPLC, also known as ultra‐high‐performance liquid chromatography, UHPLC) have become the most widely used analytical tools for detection and quantification of phytocannabinoids in various matrices. HPLC and UPLC (or UHPLC) are usually coupled to an ultraviolet (UV), photodiode array (PDA), or mass spectrometric (MS) detector.ObjectiveTo critically appraise the literature on the application of HPLC and UPLC (or UHPLC) methods for the analysis of phytocannabinoids published from January 2020 to December 2023.MethodologyAn extensive literature search was conducted using Web of Science, PubMed, and Google Scholar and published materials including relevant books. In various combinations, using cannabinoid in all combinations, cannabis, hemp, hashish, C. sativa, marijuana, analysis, HPLC, UHPLC, UPLC, and quantitative, qualitative, and quality control were used as the keywords for the literature search.ResultsSeveral HPLC‐ and UPLC (or UHPLC)‐based methods for the analysis of phytocannabinoids were reported. While simple HPLC‐UV or HPLC‐PDA‐based methods were common, the use of HPLC‐MS, HPLC‐MS/MS, UPLC (or UHPLC)‐PDA, UPLC (or UHPLC)‐MS, and UPLC (or UHPLC)‐MS/MS was also reported. Applications of mathematical and computational models for optimization of protocols were noted. Pre‐analyses included various environmentally friendly extraction protocols.ConclusionDuring the last 4 years, HPLC and UPLC (or UHPLC) remained the main analytical tools for phytocannabinoid analysis in different matrices.
Use of methylphenidate and reporting of valvular heart disease: Global pharmacovigilance analysis in children and adults
Authors: Ayme‐Dietrich Estelle , Kaguelidou Florentia , Bertschy Gilles , Chouchana Laurent 
Published: June 2024

AbstractIntroductionMethylphenidate (MPH) is a common treatment of attention‐deficit/hyperactivity disorder (ADHD). Concern has been raised regarding its cardiovascular safety, partly in relation with its micromolar affinity for the 5‐HT2B receptor, whose activation may result in valvular heart disease (VHD).MethodsTo explore the association between the use of MPH and VHD reporting, we performed a disproportionality analysis within the WHO global safety database (VigiBase) using data, since inception until March 6th 2024, from: (i) the full database and (ii) different age groups (children/adolescents 6–17 years; adults 18–64 years). To avoid competition bias, safety reports with amphetamine‐like appetite suppressants were excluded. Disproportionality was expressed using reporting odds‐ratio (ROR) and its 95% confidence interval (CI).ResultsOf 29 129 spontaneous reports with MPH, 23 VHD cases (7.9 per 10 000 reports) were identified, including 13 adults and 10 children. Most cases concerned injury on the mitral valve. A disproportionate reporting was observed overall (ROR 1.6, 95% CI 1.1–2.4). Analysis according to age group found that disproportionality in VHD reporting was found in adults only (ROR 2.7, 95% CI 1.6–4.7) but not in children/adolescents (ROR 1.7, 95% CI 0.9–3.2). Furthermore, amongst MPH users only, VHD reporting was higher in adults compared to children (ROR 2.7, 95% CI 1.2–6.3).ConclusionVHD reporting appears rare with MPH compared to other adverse events and is increased in adults only. Our findings support a potential safety signal of VHD in adults exposed to MPH. A risk in that population cannot be excluded and requires further assessment.
Facile synthesis of size‐tunable multihydroxy nanogels by self‐assembly‐induced disulfide bonds crosslinking
Authors: Zeng Hai , Chen Qingli , Mo Zhimin , Huang Xiaohua , Zhou Li 
Published: June 2024

AbstractSignificant advancements have been achieved in polymer nanogel synthesis, yet there is a dearth of methods for easily preparing size‐adjustable, surface‐modifiable, and biocompatible nanogels. This study introduces a straightforward method for fabricating hyperbranched polyglycerol (HPG) nanogels in water through self‐assembly and disulfide bond crosslinking, avoiding the use of surfactants. The process involves modifying HPG with thioctic acid (TA) to create amphiphilic HPG‐TA rich in disulfide bonds, which is then reduced to facilitate water introduction and self‐assembly. Photocrosslinking is used to finalize the formation of HPG nanogels. These nanogels feature a uniform size distribution, with hydrodynamic diameters tunable from around 90 to 400 nm by tweaking synthesis variables. They have shown low cytotoxicity and high stability in aqueous media, with notable sensitivity to pH, especially in acidic conditions (e.g., pH 3), and redox‐responsiveness, as evidenced by reactions to 10 mM dithiothreitol (DTT). The nanogels' multiple hydroxyl groups enable easy functionalization, exemplified by the synthesis of fluorescent HPG‐RB nanogels. This work presents an efficient strategy for producing robust HPG nanogels, potentially spurring further advancements in the field of polymer nanogel synthesis and application.
Necrotizing pneumonia associated with macrolide‐resistant Mycoplasma in a child
Authors: Ding Guodong , Yang Lan , Xu Changli , Vinturache Angela , Zhang Yongjun 
Published: June 2024

AbstractWe reported a pediatric case of necrotizing pneumonia due to macrolide‐resistant Mycoplasma pneumoniae, an uncommon presentation of a common disease. Acquisition of resistance does not increase virulence, but it leads to more difficult treatment and potential complications. Macrolide‐resistant M. pneumoniae requires extended antibiotic therapy with the addition of a second‐line agent and an immunomodulator to promote clinical improvement with minimal sequelae.
Physiologically‐based pharmacokinetic modeling of pantoprazole to evaluate the role of CYP2C19 genetic variation and obesity in the pediatric population
Authors: Thompson Elizabeth J. , Jeong Angela , Helfer Victória E. , Shakhnovich Valentina , Edginton Andrea , Balevic Stephen J. , James Laura P. , Collier David N. , Anand Ravinder , Gonzalez Daniel ,   the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee
Published: June 2024

AbstractPantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal reflux disease, a condition that disproportionately affects children with obesity. Appropriately dosing pantoprazole in children with obesity requires understanding the body size metric that best guides dosing, but pharmacokinetic (PK) trials using traditional techniques are limited by the need for larger sample sizes and frequent blood sampling. Physiologically‐based PK (PBPK) models are an attractive alternative that can account for physiologic‐, genetic‐, and drug‐specific changes without the need for extensive clinical trial data. In this study, we explored the effect of obesity on pantoprazole PK and evaluated label‐suggested dosing in this population. An adult PBPK model for pantoprazole was developed using data from the literature and accounting for genetic variation in CYP2C19. The adult PBPK model was scaled to children without obesity using age‐associated changes in anatomical and physiological parameters. Lastly, the pediatric PBPK model was expanded to children with obesity. Three pantoprazole dosing strategies were evaluated: 1 mg/kg total body weight, 1.2 mg/kg lean body weight, and US Food and Drug Administration‐recommended weight‐tiered dosing. Simulated concentration–time profiles from our model were compared with data from a prospective cohort study (PAN01; NCT02186652). Weight‐tiered dosing resulted in the most (>90%) children with pantoprazole exposures in the reference range, regardless of obesity status or CYP2C19 phenotype, confirming results from previously published population PK models. PBPK models may allow for the efficient study of physiologic and developmental effects of obesity on PK in special populations where clinical trial data may be limited.
Gas chromatography/mass spectrometry analysis of reaction products of Chemical Weapons Convention–related 2‐(N,N‐dialkylamino)ethylchlorides with 2‐(N,N‐dialkylamino)ethanols
Authors: Rodda Ramesh , Malkapuri Nikita Singh , Addipilli Ramunaidu , Vattem Venkata Swarajya Lakshmi , Kantevari Srinivas , Thota Jagadeshwar Reddy , Sripadi Prabhakar 
Published: June 2024

RationaleThe Chemical Weapons Convention (CWC) mandates rigorous screening of chemical weapons and their potential degradation/reaction products, which is essential to identify such products in suspected samples. The reaction between 2‐(N,N‐dialkylamino)ethylchlorides and 2‐(N,N‐dialkylamino)ethanols (precursors/degradation products of VX agents) produces a new class of reaction products that are not explored.MethodsThe reaction products, bis(2‐N,N‐dialkylaminoethyl)ethers (1–10), were synthesized using established synthetic procedures, and gas chromatography/mass spectrometry (GC/MS) (electron ionization [EI] and chemical ionization [CI]) methods were developed for their identification. The GC/MS experiments were performed on an Agilent GC/MSD system using an HP‐5MS capillary column. Methane gas was used as the CI reagent gas for GC/CIMS experiments. GC/retention index (RI) values of 1–10 were calculated using the retention times of the hydrocarbon mixture and the analytes.ResultsThe GC/EI spectra of 1–10 exhibited [M‐H]+ ions and distinctive fragments that provided valuable structural information. The selective fragmentation of the alkyl groups on nitrogen facilitated the discrimination of possible isomeric compounds. Interpretation of EI fragments in the high mass region is important for unambiguous identification of 1–10, because the major ions significantly match other CWC‐related compounds containing the 2‐(N,N‐dialkylaminoethyl) group. GC/CI (methane) spectra included M+., [M + H]+, [M‐H]+, reagent‐specific adduct ions, and a few structure‐indicative fragments. The spiking experiments in soil and water samples revealed that the target analytes were stable, easily extractable, and detectable using GC/MS.ConclusionsThe reaction products, 1–10, could be successfully synthesized and characterized using GC/MS (EI and CI). The GC/MS and GC/RI data provide important insights into the unambiguous identification of the target molecules in challenging CWC verification and are helpful in participation in the Organization for the Prohibition of Chemical Weapons proficiency tests.
Adaptive neural dynamic surface control for nonstrict feedback systems with state delays
Authors: Sun Meng , Yang Hong , Sun Jing , Xu Shengyuan 
Published: June 2024

AbstractThis article focuses on a class of nonstrict feedback systems with input delay, state delays and time‐varying full‐state constraints by proposing an adaptive neural control scheme. To overcome the problems of all state variables effected by time‐varying constraints, the asymmetric time‐varying barrier Lyapunov functions are constructed. The influence of state delays and input delay is eliminated by employing suitable Lyapunov–Krasovskii functionals. Additionally, the process of controller design is based on backstepping method and the unknown functions can be approximated by radial basis function neural networks. Moreover, the problem of repeated differentiations for nonlinear components during controller design is hugely simplified by taking advantage of the dynamic surface control method. The boundness of all the closed‐loop signals can be ensured by the designed controller. Finally, two numerical simulations illustrate that the proposed adaptive neural control scheme is effective.
Professional Development in Reading Comprehension: A Meta‐analysis of the Effects on Teachers and Students
Authors: Rice Marianne , Lambright Kacee , Wijekumar Kausalai (Kay) 
Published: June 2024

AbstractReading comprehension instruction was identified by the National Reading Panel as an effective instructional practice to improve students' reading comprehension. Teacher professional development (PD) is essential for effective reading comprehension instruction to occur in schools. The aim of this meta‐analysis is to examine the extent to which teacher PD in reading comprehension impacted teacher knowledge or practice outcomes and student reading comprehension outcomes. Additionally, we explored whether various studies or PD characteristics were potential moderators of these outcomes. We identified 29 experimental and quasi‐experimental studies, including 51 independent samples and 97 effect sizes. Using robust variance estimation, teacher PD in reading comprehension had a large effect (g = 0.947, p < .001) on teacher knowledge or practice and a small effect (g = 0.193, p < .001) on student reading comprehension. Results indicate teacher PD in reading comprehension is effective in improving teaching practices and student learning. However, more systematic research is needed to investigate effective PD components and other factors which may influence the impact of PD on teacher and student outcomes.
Assessment of the real‐time pattern recognition capability of machine learning algorithms
Authors: Polytarchos Elias , Bardaki Cleopatra , Pramatari Katerina 
Published: June 2024

AbstractNowadays data streams from different sources, like blockchain‐based and traditional financial transactions, social networks, and interconnected Internet of Things (IoT) devices, are becoming increasingly large in volume and the need to recognize patterns in real time from these streams, while adapting to their velocity and veracity, is emerging. Established machine learning algorithms used for pattern recognition methods have not been designed taking under account the volume, velocity, diversity, and accuracy of the data streams. This research contributes with an approach for assessing the pattern recognition capabilities of established machine learning algorithms when handling volatile data in real time and proposes a system that adapts the algorithms to the requirements of data streams, as well as assesses their pattern recognition capabilities based on established criteria. The system was applied for assessing five machine learning algorithms with input from a data stream from Bluetooth beacons tracking consumers in a retail store. This research can support future data scientists and analysts who need to reveal data patterns in big, volatile data streams in real time in order to support effective decision‐making in the respective application domain. Copyright © 2024 John Wiley & Sons, Ltd.
Asymmetric Assembly in Microdroplets: Efficient Construction of MOF Micromotors for Anti‐Gravity Diffusion
Authors: Liu Rong‐Kun , Guo Yanling , Jia Jia , Sun Qian , Zhao Hong , Wang Jie‐Xin 
Published: June 2024

AbstractJanus‐micromotors, as efficient self‐propelled materials, have garnered considerable attention for their potential applications in non‐agitated liquids. However, the design of micromotors is still challenging and with limited approaches, especially concerning speed and mobility in complex environments. Herein, a two‐step spray‐drying approach encompassing symmetrical assembly and asymmetrical assembly is introduced to fabricate the metal‐organic framework (MOF) Janus‐micromotors with hierarchical pores. Using a spray‐dryer, a symmetrical assembly is first employed to prepare macro‐meso‐microporous UiO‐66 with intrinsic micropores (<0.5 nm) alongside mesopores (≈24 nm) and macropores (≈400 nm). Subsequent asymmetrical assembly yielded the UiO‐66‐Janus loaded with the reducible nanoparticles, which underwent oxidation by KMnO4 to form MnO2 micromotors. The micromotors efficiently generated O2 for self‐propulsion in H2O2, exhibiting ultrahigh speeds (1135 µm s−1, in a 5% H2O2 solution) and unique anti‐gravity diffusion effects. In a specially designed simulated sand‐water system, the micromotors traversed from the lower water to the upper water through the sand layer. In particular, the as‐prepared micromotors demonstrated optimal efficiency in pollutant removal, with an adsorption kinetic coefficient exceeding five times that of the micromotors only possessing micropores and mesopores. This novel strategy fabricating Janus‐micromotors shows great potential for efficient treatment in complex environments.
Mirror Plane Effect of Magnetoplumbite‐Type Oxide Restraining Long‐Chain Polysulfides Disproportionation for High Loading Lithium Sulfur Batteries
Authors: Zhou Lin , Zhang Xinrui , Hao Weiju , Sun Sida , Wang Ruirui , Liu Handing 
Published: June 2024

AbstractA facile solid‐state approach is employed to synthesize a novel magnetoplumbite‐type oxide of NdMgAl11O19, which integrates spinel‐stacking layers (MgAl2O4) with Nd‐O6 mirror plane structures. The resulting NdMgAl11O19 exhibits remarkable catalytic activity and conversion efficiency during the sulfur reduction reaction (SRR) in lithium‐sulfur batteries. By employing the 2D projection mapping technique of in situ confocal Raman spectroscopy and electrochemical technique, it is discovered that the exposed mirror plane structure of Nd‐O6 can effectively suppress the undesiring disproportionation reaction (S82−→S62−+1/4 S8) of long‐chain lithium polysulfides at the initial stages of sulfur reduction, thereby promoting the positive process of sulfur to lithium sulfide. This not only mitigates the issue of sulfur shuttle loss but also significantly improve the kinetics of the conversion process. Leveraging these advantages, the NdMgAl11O19/S cathode delivered an impressive initial capacity of up to 1398 mAh g−1 at an electrolyte/sulfur (E/S) ratio of 5.1 µL mg−1 and a sulfur loading of 2.3 mg cm−2. Even when the sulfur loading is increased to 10.02 mg cm−2, the cathode retained a reversible areal capacity of 10.01 mAh cm−2 after 200 cycles. This mirror engineering strategy provides valuable and universal insights into enhancing the efficiency of cathodes in Li‐S battery.
Isolation, identification, antibiotic resistance profile and molecular analysis of Ornithobacterium rhinotracheal isolates from turkeys
Authors: Yusefinejad Sedigheh , Gharibi Darioush , Khosravi Mohammad , Mayahi Mansour , Shapouri Masoud Reza Seyfi Abad 
Published: June 2024

AbstractBackgroundOrnithobacterium rhinotracheal (ORT) infects numerous birds, particularly chickens and turkeys. ORT is an emerging bacterial pathogen of global concern in the poultry industry. As ORT is rapidly spreading throughout commercial poultry, it requires intensive studies of its epidemiology, diagnostic procedures, molecular typing, virulence genes and antimicrobial resistance.ObjectivesThe present study was conducted in isolation and identification of ORT from slaughtered turkeys.MethodsCleft palate swabs of 200 were collected from slaughtered turkeys and cultured on blood agar. ORT was characterized using biochemical tests and PCR targeting the ORT 16S rRNA gene. Virulence genes of isolates were determined targeting adenylate kinase (adk), copA and virulence‐associated protein D (vapD) genes. Additionally, diversity of ORT isolates was performed by enterobacterial repetitive intergenic consensus (ERIC) and RAPD PCR. Disk diffusion was used to determine the antibiotic sensitivity of the isolates.ResultsORT was identified in 23 (11.5%) samples using both the biochemical tests and PCR. The result of detecting virulence genes showed that all the isolates (23: 100%) had the adk gene, whereas two (8.7%) isolates had the copA gene, and seven (30.43%) isolates had the vapD gene. Molecular typing of isolates revealed 21 different patterns by RAPD PCR assay using M13 primer and 20 distinct patterns by ERIC PCR test. Both ERIC and RAPD PCR were distinctive methods for investigating the genetic diversity of ORT isolates. The antibiotic resistance test showed that 18 (78.26%) isolates were resistant to gentamicin, amikacin, cefazolin, streptomycin and penicillin. All isolates (100%) were resistant to cloxacillin and fosfomycin.ConclusionsThis study showed the prevalence of ORT in turkey and high resistance of this bacterium to many common veterinary antibiotics. Moreover, both ERIC and RAPD PCR are distinctive methods for investigating the genetic diversity of ORT isolates. These data may help monitor antibiotic resistance and typing of ORT in epidemiological studies and serve as the foundation for designing region‐specific vaccines for future use.