bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quand des associations font face aux failles des politiques publiques
Authors: Chemin Carine 
Published: October 2011

Résumé L’article consiste en une lecture des stratégies associatives en fonction des quatre « discours » de Lacan. L’ambition est de montrer qu’il existe différentes façons pour les managers de considérer les interstices que recèle l’environnement, ici ramené aux politiques publiques. L’association 1 base sa stratégie sur le repérage de lignes budgétaires inutilisées ou d’interstices dans les textes législatifs nouveaux qui mettent le « maître » Conseil général ou CAF en position d’obligation de réponse à une obligation légale. Cette stratégie est une stratégie d’esclave. L’association 2 base sa stratégie sur une fine connaissance des travaux d’experts dans son champ et elle propose/ impose aux acteurs locaux des innovations qui s’inscrivent dans ces travaux d’experts. Il s’agit d’une stratégie de type maître moderne. L’objet de l’association 3 est de proposer aux pouvoirs publics des projets qui correspondent à des besoins repérés sur le terrain et à des envies des bénévoles impliqués dans l’association. Ces projets sont pensés en-dehors des pouvoirs publics, dans une dynamique interne basée sur l’expression du désir des bénévoles. Le projet de cette association est d’essence hystérique et il fait apparaître les failles des dispositifs publics dans une dynamique d’où les stratégies de séduction ne sont pas absentes.
Le Moi subverti par le sujet s'autorisant parfois à être malicieux
Authors: Botet-Pradeilles Georges , Drillon Dominic 
Published: October 2011

Résumé Entre psychanalyse et management, parler d’interstices est un euphémisme, nous aurions pu dire aussi abîme. L’objet de cette communication est de montrer quels espaces de liberté et d’action peuvent se créer si on les confronte l’un à l’autre. Lacan disait par l’une de ses formules joueuses : « Lorsque je suis, je ne me pense pas » en paraphrasant Descartes. Le valet de Comédie n’est pas dans la position de ses maîtres auxquels il importe de dominer, de contrôler, de savoir, de posséder, de séduire. Il est indifférent aux acquis hiérarchiques et territoriaux et mène son jeu malicieux dans l’invention, le plaisir et l’aventure. Son adaptation subjective lui donne une plasticité qui devient peu à peu sa nature qui rend plaisante et nécessaire la leçon de la Comédie. Le Moi dans ses schèmes, ses conditionnements, toutes les matérialités et les contraintes périphériques intériorisées qui le constituent, s’efface pour laisser place à une nouvelle vision, un nouvel énoncé, une émergence qui fait surprise et invente un nouveau fonctionnement. Piaget voyait là le processus d’accommodation qui amène le vivant organique ou intelligent vers de nouveaux stades « majorants » d’équilibration... La quête de larves enfouies demandait un bec plus fin à certains pinsons de Darwin. La malice de l’évolution le leur donna par son jeu secret qui offre les moyens aux fins utiles sans nul secours d’une conscience.
Phagosomal Degradation Increases TLR Access to Bacterial Ligands and Enhances Macrophage Sensitivity to Bacteria
Authors: Wolf Andrea J. , Arruda Andrea , Reyes Christopher N. , Kaplan Amber T. , Shimada Takahiro , Shimada Kenichi , Arditi Moshe , Liu George , Underhill David M. 
Published: October 2011

Abstract
Signaling by innate immune receptors initiates and orchestrates the overall immune responses to infection. Macrophage receptors recognizing pathogens can be broadly grouped into surface receptors and receptors restricted to intracellular compartments, such as phagosomes and the cytoplasm. There is an expectation that ingestion and degradation of microorganisms by phagocytes contributes to activation of intracellular innate receptors, although direct demonstrations of this are rare, and many model ligands are studied in soluble form, outside of their microbial context. By comparing a wild-type strain of Staphylococcus aureus and a lysozyme-sensitive mutant, we have been able directly to address the role of degradation of live bacteria by mouse macrophages in determining the overall innate cellular inflammatory response. Our investigations revealed a biphasic response to S. aureus that consisted of an initial signal resulting from the engagement of surface TLR2, followed by a later, second wave on inflammatory gene induction. This second wave of inflammatory signaling was dependent on and correlated with the timing of bacterial degradation in phagosomes. We found that TLR2 signaling followed by TLR2/TLR9 signaling enhanced sensitivity to small numbers of bacteria. We further found that treating wild-type bacteria with the peptidoglycan synthesis-inhibiting antibiotic vancomycin made S. aureus more susceptible to degradation and resulted in increased inflammatory responses, similar to those observed for mutant degradation-sensitive bacteria.
The Actin Regulatory Protein HS1 Is Required for Antigen Uptake and Presentation by Dendritic Cells
Authors: Huang Yanping , Biswas Chhanda , Klos Dehring Deborah A. , Sriram Uma , Williamson Edward K. , Li Shuixing , Clarke Fiona , Gallucci Stefania , Argon Yair , Burkhardt Janis K. 
Published: October 2011

Abstract
The hematopoietic actin regulatory protein hematopoietic lineage cell-specific protein 1 (HS1) is required for cell spreading and signaling in lymphocytes, but the scope of HS1 function in Ag presentation has not been addressed. We show that dendritic cells (DCs) from HS1−/− mice differentiate normally and display normal LPS-induced upregulation of surface markers and cytokines. Consistent with their normal expression of MHC and costimulatory molecules, HS1−/− DCs present OVA peptide efficiently to CD4+ T cells. However, presentation of OVA protein is defective. Similarly, MHC class I-dependent presentation of VSV8 peptide to CD8+ T cells occurs normally, but cross-presentation of GRP94/VSV8 complexes is defective. Analysis of Ag uptake pathways shows that HS1 is required for receptor-mediated endocytosis, but not for phagocytosis or macropinocytosis. HS1 interacts with dynamin 2, a protein involved in scission of endocytic vesicles. However, HS1−/− DCs showed decreased numbers of endocytic invaginations, whereas dynamin-inhibited cells showed accumulation of these endocytic intermediates. Taken together, these studies show that HS1 promotes an early step in the endocytic pathway that is required for efficient Ag presentation of exogenous Ag by DCs.
Immune Regulation through Mitochondrion-Dependent Dendritic Cell Death Induced by T Regulatory Cells
Authors: Chen Min , Felix Kumar , Wang Jin 
Published: October 2011

Abstract
Dendritic cells (DCs) harbor an active mitochondrion-dependent cell death pathway regulated by Bcl-2 family members and undergo rapid turnover in vivo. However, the functions for mitochondrion-dependent cell death of DCs in immune regulation remain to be elucidated. In this article, we show that DC-specific knockout of proapoptotic Bcl-2 family members, Bax and Bak, induced spontaneous T cell activation and autoimmunity in mice. In addition to a defect in spontaneous cell death, Bax−/−Bak−/− DCs were resistant to killing by CD4+Foxp3+ T regulatory cells (Tregs) compared with wild-type DCs. Tregs inhibited the activation of T effector cells by wild-type, but not Bax−/−Bak−/−, DCs. Bax−/−Bak−/− DCs showed increased propensity for inducing autoantibodies. Moreover, the autoimmune potential of Bax−/−Bak−/− DCs was resistant to suppression by Tregs. Our data suggested that Bax and Bak mediate intrinsic spontaneous cell death in DCs, as well as regulate DC killing triggered by Tregs. Bax- and Bak-dependent cell death mechanisms help to maintain DC homeostasis and contribute to the regulation of T cell activation and the suppression of autoimmunity.
Formation of B-1 B Cells from Neonatal B-1 Transitional Cells Exhibits NF-κB Redundancy
Authors: Montecino-Rodriguez Encarnacion , Dorshkind Kenneth 
Published: October 2011

Abstract
The stages of development leading up to the formation of mature B-1 cells have not been identified. As a result, there is no basis for understanding why various genetic defects, and those in the classical or alternative NF-κB pathways in particular, differentially affect the B-1 and B-2 B cell lineages. In this article, we demonstrate that B-1 B cells are generated from transitional cell intermediates that emerge in a distinct neonatal wave of development that is sustained for ∼2 wk after birth and then declines as B-2 transitional cells predominate. We further show that, in contrast to the dependence of B-2 transitional cells on the alternative pathway, the survival of neonatal B-1 transitional cells and their maturation into B-1 B cells occurs as long as either alternative or classical NF-κB signaling is intact. On the basis of these results, we have generated a model of B-1 development that allows the defects in B-1 and B-2 cell production observed in various NF-κB–deficient strains of mice to be placed into a coherent cellular context.
Harmonic Analysis Related to Homogeneous Varieties in Three Dimensional Vector Spaces over Finite Fields
Authors: Koh Doowon , Shen Chun-Yen 
Published: October 2011

Abstract In this paper we study the extension problem, the averaging problem, and the generalized Erdős-Falconer distance problem associated with arbitrary homogeneous varieties in three dimensional vector spaces over finite fields. In the case when the varieties do not contain any plane passing through the origin, we obtain the best possible results on the aforementioned three problems. In particular, our result on the extension problem modestly generalizes the result by Mockenhaupt and Tao who studied the particular conical extension problem. In addition, investigating the Fourier decay on homogeneous varieties enables us to give complete mapping properties of averaging operators. Moreover, we improve the size condition on a set such that the cardinality of its distance set is nontrivial.
College of American Pathologists Proposal for the Oversight of Laboratory-Developed Tests
Authors: Vance Gail H. 
Published: October 2011

Context.—The US Food and Drug Administration (FDA) announced it will exercise authority over laboratory-developed tests (LDTs). Laboratory-developed tests have traditionally been developed and offered in laboratories as a service to patients and regulated under the Clinical Laboratory Improvement Amendments of 1988 (Clinical Laboratory Improvements Act). Laboratories now face potential dual regulatory oversight from both the Centers for Medicare and Medicaid Services (CMS) and the FDA. The College of American Pathologists (CAP) constructed a proposal to minimize redundancy of agency oversight and burden to laboratories. Modifications to the proposal continue while the laboratory community awaits release of the guidance documents that will stipulate FDA requirements.
Objective.—To describe the historical context framing the entry of FDA into the oversight of LDTs and outline the CAP LDT Proposal in its current form.
Data Sources.—PubMed review of published literature; United States Constitution; and online information resources from the National Institutes of Health, FDA, and US Government.
Conclusion.—The College of American Pathologists is a leader in laboratory quality and has unique insights into the benefits and risks to patients presented by LDTs. Continued dialog with officials from the FDA and CMS will promote public and private collaborative efforts to assure innovation of diagnostic testing, public information, and patient safety for clinical diagnostic testing.
Experimentelle Tragsicherheitsbewertung von Stahlbetonbauteilen ohne Querkraftbewehrung
Authors: Schacht Gregor , Bolle Guido , Marx Steffen 
Published: October 2011

AbstractFür die experimentelle Untersuchung von bestehenden Stahlbetonkonstruktionen ist es entscheidend, dass das Tragverhalten unmittelbar während des Versuches genau analysiert und bewertet werden kann. Nur dadurch kann ein sich ankündigendes Versagen rechtzeitig erkannt und eine unzulässig starke Schädigung der Struktur vermieden werden.Anders als beim Biegeversagen ist dies für gering‐duktile Versagensarten, wie z. B. für das Schubversagen von Stahlbetonbauteilen ohne Bügelbewehrung, aufgrund ihrer geringen Vorankündigung bisher nicht sicher möglich.Der Beitrag gibt einen Einblick in die Problematik der Bewertung der Schubbruchgefahr bestehender Stahlbetontragwerke und erläutert, welche Einflussparameter für eine Beurteilung, insbesondere im Zusammenhang mit Belastungsversuchen, zu berücksichtigen sind. In den durchgeführten experimentellen Untersuchungen wurden unterschiedliche Messtechniken (herkömmliche Verformungsmesstechnik, Photogrammetrie und Schallemissionsanalyse) mit einander kombiniert und hinsichtlich ihrer Eignung zur Registrierung bereits kleinster Strukturveränderungen untersucht.Experimental Assessment of the structural safety of reinforced concrete structures without shear reinforcement. For the experimental investigation of existing concrete structures it is crucial to be able to analyze and assess the load bearing behavior online during the loading test. Only this ensures that a pronouced failure or an inacceptable damage of the structure can be avoided in the test.Unlike bending failure, this assessment is rather difficult and not yet securely possible for low‐ductile types of failure, like the shear failure of reinforced concrete structures members without web reinforcement.This paper explains the difficulties of assessing the danger of shear failures of reinforced concrete structures und discusses which main influencing factors have to be considered for an evaluation and especially for the case of a loading test. For the experimental tests, which have been carried out, different measuring techniques (usual deformation measurement techniques, photogrammetry and acoustic emission analysis) were combined and tested regarding their suitability for the detection of smallest structural changes.
ChemInform Abstract: Direct Growth of Flexible LiMn2O4/CNT Lithium‐Ion Cathodes.
Authors: Jia Xilai , Yan Chunzhu , Chen Zheng , Wang Ranran , Zhang Qiang , Guo Lin , Wei Fei , Lu Yunfeng 
Published: October 2011

AbstractSpontaneous redox reactions between mildly pre‐oxidized carbon nanotubes and KMnO4 (90 °C, 4 h) generate layers of MnO2 wrapped around the carbon nanotubes.
ChemInform Abstract: A 3,4‐Connected Beryllium Phosphite Framework Containing 24‐Ring Channels with a Very Low Density.
Authors: Luo Xiuchao , Luo Daibing , Zeng Hongmei , Gong Maochu , Chen Yaoqiang , Lin Zhien 
Published: October 2011

AbstractThe new organically templated three‐dimensional open‐framework compound (BuNH3)2[Be3(HPO3)4] is solvothermally synthesized from a mixture of BeSO4, H3PO3, BuNH2, and EtOH (autoclave, 170 °C, 5 d, 71% yield).
ChemInform Abstract: Cationic Boron‐Centered Hexanuclear Zirconium Cluster Compounds with Nitrilo Ligands and [MIIICl4]‐ Counter Ions: [(Zr6B)Cl12(CH3CN)6] [MIIICl4] with MIII: Al, Ga, In.
Authors: Bernsdorf Arne , Koeckerling Martin 
Published: October 2011

AbstractThe chemical equilibria between different [(Zr6B)Cli12 (MeCN)6‐yClay]1‐y (0 ≤ y ≤ 6) clusters in MeCN solution is shifted to y = 0, i.e.
ChemInform Abstract: A Chiral Metal—Organic Framework for Sequential Asymmetric Catalysis.
Authors: Song Feijie , Wang Cheng , Lin Wenbin 
Published: October 2011

AbstractThe preparation of a chiral metal‐organic framework (MOF) catalyst incorporating a Mn‐salen complex and its application in highly regio‐ and stereoselective sequential alkene epoxidation/epoxide ring‐opening reactions are presented.
ChemInform Abstract: Cycloaddition Reactions of Ethyl (E)‐ and (Z)‐3‐Fluoropropenoate.
Authors: Patrick Timothy B. , Neumann Joshua , Tatro Allison 
Published: October 2011

AbstractAn endo‐selective cycloaddition of (Z)‐fluoropropenoate (V) with dienes (I) is observed, whereas the (E)‐fluoropropenoate (II) gives a mixture of exo and endo products (III) and (IV).
ChemInform Abstract: A Practical, One‐Pot Multicomponent Synthesis of α‐Amidosulfides and Their Application as Latent N‐Acylimines in the Friedel—Crafts Reaction.
Authors: George Nicolas , Bekkaye Mathieu , Masson Geraldine , Zhu Jieping 
Published: October 2011

AbstractReaction of aliphatic aldehydes, carbamates and phenylsulfinic acid affords α‐amidosulfones which are in situ converted into α‐amidosulfides.
ChemInform Abstract: Aerobic, Cu‐Catalyzed Desulfitative C—C Bond‐Forming Reaction of Ketene Dithioacetals/Vinylogous Thioesters and Arylboronic Acids.
Authors: Dong Ying , Wang Mang , Liu Jun , Ma Wei , Liu Qun 
Published: October 2011

AbstractThe synthesis of compounds (III), (VI), and (VIII) uses attractive, readily available ketene dithioacetals and involves dual catalysis of Cu for the activation of thioorganics without the use of an S‐pendant.
ChemInform Abstract: Studies on the Radical Cyclization of 3‐Oxopropanenitriles and Alkenes with Cerium(IV) Ammonium Nitrate in Ether Solvents.
Authors: Yilmaz Mehmet 
Published: October 2011

AbstractTHF is found to be the most effective solvent for the synthesis of 4,5‐dihydrofurans.
ChemInform Abstract: A New Procedure for the Preparation of 2‐Vinylindoles and Their [4 + 2] Cycloaddition Reaction.
Authors: Mohamed Yaseen Ali Mosa , Inagaki Fuyuhiko , Takahashi Ryohei , Mukai Chisato 
Published: October 2011

AbstractThe frameworks are formed via 5‐exo‐mode cyclization of allenylanilines.
ChemInform Abstract: Visible Light‐Induced Intramolecular Cyclization Reactions of Diamines: A New Strategy to Construct Tetrahydroimidazoles.
Authors: Xuan Jun , Cheng Ying , An Jing , Lu Liang‐Qiu , Zhang Xiao‐Xiao , Xiao Wen‐Jing 
Published: October 2011

AbstractThis catalytic photoredox reaction shows high diastereoselectivity and affords highly substituted tetrahydroimidazole derivatives under mild conditions in excellent yields.
ChemInform Abstract: N‐Aryl‐2‐nitrosoanilines as Intermediates in the Two‐Step Synthesis of Substituted 1,2‐Diarylbenzimidazoles from Simple Nitroarenes.
Authors: Wrobel Zbigniew , Stachowska Karolina , Grudzien Krzysztof , Kwast Andrzej 
Published: October 2011

AbstractNitroso‐substituted diarylamines, previously prepared from nitrobenzenes and anilines, undergo base‐mediated condensation with benzyl aryl sulfones to afford the title compounds generally in good yields.
ChemInform Abstract: Chlorination and ortho‐Acetoxylation of 2‐Arylbenzoxazoles.
Authors: Leng Yuting , Yang Fan , Zhu Weiguo , Wu Yangjie , Li Xiang 
Published: October 2011

AbstractAcetoxylation of 2‐arylbenzoxazoles (I) is ligand‐controlled and proceeds regioselectively at the ortho‐position of the 2‐aryl ring [cf.
ChemInform Abstract: “One‐Flask” Synthesis to 3,5‐Disubstituted 1,2,4‐Triazoles from Aldehydes with Hydrazonoyl Hydrochlorides via 1,3‐Dipolar Cycloaddition.
Authors: Tseng Wen‐Che , Wang Li‐Ya , Wu Tian‐Shung , Wong Fung Fuh 
Published: October 2011

AbstractHydrazonyl hydrochlorides are concerned as the masked 1,3‐dipole nitrilimines under basic conditions which react with in situ formed oxime intermediates.
ChemInform Abstract: Palladium(0)‐Catalyzed Cross‐Coupling of 2‐Trimethylsilylpyridine with Aryl Halides.
Authors: Blakemore David C. , Marples Louise A. 
Published: October 2011

AbstractThe Hiyama coupling of substrate (I) with aryl halides is optimized including CataCXium A as the optimal ligand.
ChemInform Abstract: New Heterocyclic Inputs for the Povarov Multicomponent Reaction.
Authors: Vicente‐Garcia Esther , Ramon Rosario , Lavilla Rodolfo 
Published: October 2011

AbstractVarious 5‐membered heterocycles such as imidazolone and analogues are investigated as novel components for the title reaction opening an access to heterocycle‐annulated quinoline systems.
ChemInform Abstract: Regioselective Syntheses of Substituted Pyridines and 2,2′‐Bipyridines by Cobalt‐Catalyzed [2 + 2 + 2] Cycloaddition of α,ω‐Diynes with Nitriles.
Authors: Sugiyama Yuki , Okamoto Sentaro 
Published: October 2011

Abstractα,ω‐Diynes react with nitriles under conditions A) to give annulated pyridine systems.
ChemInform Abstract: Novel Purine‐Based Fluoroaryl‐1,2,3‐triazoles as Neuroprotecting Agents: Synthesis, Neuronal Cell Culture Investigations, and CDK5 Docking Studies.
Authors: Nair Nanditha , Kudo Wataru , Smith Mark A. , Abrol Ravinder , Goddard William A. III , Reddy V. Prakash 
Published: October 2011

AbstractKey reaction in the synthesis of the title compounds (V) is a Cu(I) catalyzed azide alkyne Huisgen cycloaddition (click reaction).
ChemInform Abstract: Regioselectivity in the Amination of Azines: Reaction of Pyrazine Derivatives with O‐Mesitylenesulfonylhydroxylamine.
Authors: Borodkin G. I. , Vorob'ev A. Yu. , Shakirov M. M. , Shubin V. G. 
Published: October 2011

AbstractThe data obtained on the regioselectivity of amination are interpreted in terms of DFT/PBE/3Z quantum‐chemical calculations.
ChemInform Abstract: A Novel, One‐Pot Four‐Component Route to 2′‐Thioxo‐2′,3′‐dihydrospiro[indole‐3,6′‐[1,3]thiazin]‐2‐one Derivatives.
Authors: Alizadeh Abdolali , Mokhtari Javad 
Published: October 2011

AbstractThe formation of the title spiro compounds is proposed to proceed via cyclization of an in situ generated α,β‐unsaturated ketone derived from isatin (I) and phosphorane (II) with the carbamodithioate resulting from the addition of the amine to CS2.
ChemInform Abstract: Reactions of Lithiated Alkynes and Allenes with Isothiocyanates: A Simple and Efficient Synthesis of New Aryl‐ or Hetaryl‐Substituted 3H‐Azepines and 4,5‐Dihydro‐3H‐azepines.
Authors: Nedolya Nina A. , Tarasova Ol'ga A. , Volostnykh Ol'ga G. , Albanov Alexander I. , Klyba Ludmila V. , Trofimov Boris A. 
Published: October 2011

AbstractA general protocol for the preparation of target compounds (VI)/(VII) involves the synthesis of allenes (IV), their mild thermal isomerization to trienes (V) followed by base‐promoted cyclization.
ChemInform Abstract: Efficient Synthesis of 3‐O‐Thia‐cPA and Preliminary Analysis of Its Biological Activity Toward Autotaxin.
Authors: Tanaka Ryo , Kato Masaru , Suzuki Takahiro , Nakazaki Atsuo , Nozaki Emi , Gotoh Mari , Murakami‐Murofushi Kimiko , Kobayashi Susumu 
Published: October 2011

AbstractCyclic thiophosphatidic acids of type (V) (4 examples) are prepared involving an intramolecular Arbuzov reaction as the key step.
ChemInform Abstract: Defining Oxyanion Reactivities in Base‐Promoted Glycosylations.
Authors: Matwiejuk Martin , Thiem Joachim 
Published: October 2011

AbstractThe absolute and relative yields of the NaH promoted glycosylation of trimethylated α‐D‐glucopyranosides with 2,3,4,6‐tetra‐O‐methyl‐α‐D‐galactopyranosyl chloride indicate a reactivity sequence of isolated OH groups of 2‐OH < 4‐OH < 6‐OH < 3‐OH.
ChemInform Abstract: Diamond‐based Structures to Collect and Guide Light
Authors: Castelletto S. , Harrison J. P. , Marseglia L. , Stanley‐Clarke A. C. , Gibson B. C. , Fairchild B. A. , Hadden J. P. , Ho Y.‐L. D. , Hiscocks M. P. , Ganesan K. , et al. et al. 
Published: October 2011

AbstractReview: 63 refs.
ChemInform Abstract: Biosynthesis, Asymmetric Synthesis, and Pharmacology, Including Cellular Targets, of the Pyrrole‐2‐aminoimidazole Marine Alkaloids
Authors: Al‐Mourabit Ali , Zancanella Manuel A. , Tilvi Supriya , Romo Daniel 
Published: October 2011

AbstractReview: ca. 200 refs.
Binderless Zeolite Molecular Sieves of the LTA and FAU Type
Authors: Schumann Kristin , Brandt Alfons , Unger Baldur , Scheffler Franziska 
Published: October 2011

AbstractZeolithische Molekularsiebe gehören nach wie vor zu den industriell bedeutendsten Adsorbentien. In dynamischen, technischen Adsorptionsprozessen ist die Verwendung von Formkörpern unumgänglich. Diese werden konventionell mithilfe von mineralischen Bindemitteln hergestellt. In diesem Artikel werden neuartige, bindemittelfreie Molekularsiebe und deren Vorteile gegenüber den konventionellen, bindemittelhaltigen Produkten beschrieben.