bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of interactive effects of sowing window and genotype, especially over intensity of disease outbreak and its consequences on vital yield and quality parameters of Tomato (Solanum lycopersicum L.)
Authors: Debnath Abhijit , Mohanty A. K. , Singha A K , Debbarma Rubin , Bhowmik Tanmoy , Das Bapi , Kumar Rahul , Shaktivel T 
Published: May 2024

Abstract

In order to identify the most efficient combination of two components, viz., sowing windows and genotypes of tomato, the current study was conducted in the Northern Tripura as an autumn-winter crop. The complete trial's findings demonstrated the negative impacts of high and frequent occurrences of tomato diseases, including tomato yellow leaf curl virus (TYCLV), bacterial wilt, early and late blight, on yield and quality characteristics. When transplanting was mostly done as late as 7th December during both the years, the maximum intensities of TYCLV, bacterial wilt, early and late blight of 18.69%, 10.61%, 5.55% and 6.45%, respectively, were detected with Local cultivar. On the other hand, the lowest average yield loss (1.81%) was recorded for these genotypes - Arka Abhed, Arka Rakshak, and Arka Samrat - with sowing windows as October 7th and 21st, which had higher yield potential (66.25 t ha− 1). They also had significantly better lycopene (56.43 mg 100g− 1) and carotenoids (104.00 mg 100g− 1) contents. From this, it can be inferred that growing of tomatoes in these regions during the autumn-winter months would be most fruitful, if done between the second to last week of October, using varieties such as Arka Abhed, Arka Rakshak, and Arka Samrat. If further types are to be included, genotypes like Kashi Aman and Arka Apeksha might be added and this period of transplanting duration could be prolonged up to first week of November.
Identifying the Crucial Biomarker of MASH-Related HCC
Authors: Zhou Haiyang , Zhang Yinjie , Shen Yuhang , Chen Shuai , Yang Zhen , Wang Zhihuai , Qin Xihu , Zhu Chunfu 
Published: May 2024

Objectives:
This study aimed to explore the key oncogenic factor of metabolicassociated steatohepatitis (MASH) to hepatocellular carcinoma (HCC).

Methods:
We utilized four differential GEO datasets (GSE164760, GSE139602, GSE197112,
and GSE49541) to identify the key oncogenic factor for MASH-related HCC. The differential
genes were analyzed using the GEO2R algorithm online. The GEPIA online website was used to
explore the expression of selected four genes (SPP1, GNMT, CLDN11, and THBS2). The genetic alterations in genes were estimated by the cBioPortal website. The Kaplan-Meier Plotter
online database was applied to explore the prognostic value of SPP1. Univariate and multivariate
Cox analyses were carried out to further confirm the prognostic value of SPP1. The GO and
KEGG enrichment analysis exported associated pathways with SPP1 expression. The positively
or negatively related immune cells and immune checkpoint expressions were identified through
Pearson correlation analysis. The lipogenesis-associated proteins were detected using western
blotting and fluorescence. The high-fat diet (HFD) mouse model was constructed, and liver samples were collected.

Results:
SPP1, GNMT, CLDN11, and THBS2 were determined in the transformation process of
MASH to liver fibrosis. SPP1 and GNMT were upregulated in the HCC tumor tissue. SPP1, in
particular, had the potential to be the prognostic factor through Cox analysis. Remarkably, SPP1
was highly expressed in HCC compared to normal tissues in three independent datasets
(GSE121248, GSE14520, and GSE45267). SPP1 is mainly involved in the amplification and
deep deletion mutations. SPP1 was found to be strongly correlated with ANXA2 expression, and
ANXA2 was also highly expressed in HCC with significant prognostic performance. Moreover,
SPP1 was found to participate in the carcinogenic mechanism and correlate with immune cells
and immune checkpoint expression. SPP1 knockdown suppressed the SREBP1 and FASN expressions and increased the SIRT1 expression in vitro. Moreover, the HFD model validated the
upregulation of SPP1 in the fatty liver in vivo.

Conclusion:
SPP1 may be the key oncogenic factor for the transformation of MASH to HCC,
and it could be a potential immunotherapeutic target in HCC.
Role of Video Assisted Thoracoscopic Surgery (VATS) in the Management of Pulmonary Sequestration; A Meta-Analysis
Authors: Kakamad Fahmi H. , Amin Bnar J. Hama , Ahmed Harem K. , Najmadden Zana B. , Tahir Soran H. , Abdullah Ari M. , Kareem Pavel M. , Ahmed Hawar S. , Mohammed Shvan H. , Mohammed Karukh K. , Abdalla Berun A. , Abdalla Sarhang Sedeeq , Kakamad Suhaib H. 
Published: May 2024

Background:
Pulmonary sequestration is a rare birth defect. It is a nonfunctioning dysplastic lung tissue without connection to the tracheobronchial tree, and its blood supply is from
one or more aberrant systemic arteries. The aim of this study is to review the current literature regarding the role of video-assisted thoracic surgery (VATS) in the management of pulmonary sequestration.

Objective:
This review aims to assess the safety, efficacy, and outcomes of Video-Assisted Thoracoscopic Surgery (VATS) in managing pulmonary sequestration while considering patient characteristics, symptoms, arterial sources, surgical techniques, and postoperative advantages.

Methods:
The Web of Science, PubMed, MEDLINE, and Google Scholar were searched for articles published in English. Article titles containing the words “Video-Assisted Thoracoscopic
Surgery for Pulmonary Sequestration and/or VATS” were filtered out of the search to exclude a
large portion of irrelevant studies. The extracted data were analyzed. The data extracted were presented as frequencies and percentages.

Results:
After excluding the unrelated articles, 27 studies were identified for analysis; most of the
studies (18) were case reports, with nine being case series, and the total number of patients who
underwent pulmonary sequestration by VATS was 240. Both genders were equally affected (125,
52% were male and 115, 48% were female), the most common presenting symptom was coughing,and the descending thoracic aorta was the most common artery from which the feeders originated. About 149 patients (62.08%) underwent a lobectomy.

Conclusion:
Pulmonary sequestration can safely be treated by VATS at single or multiple ports
with a shorter hospital stay, less postoperative pain, and fewer analgesic requirements.
Use of MRI Radiomics Models in Evaluating the Low HER2 Expression in
Breast Cancer
Authors: Li Hao , Hou Yan , Xue Lin-Yan , Fan Wen-Long , Gao Bu-Lang , Yin Xiao-Ping 
Published: May 2024

Objective:
To investigate the magnetic resonance imaging (MRI) radiomics models in evaluating the human epidermal growth factor receptor 2(HER2)
expression in breast cancer.

Materials and Methods:
The MRI data of 161 patients with invasive ductal carcinoma (non-special type) of breast cancer were retrospectively collected, and the MRI
radiomics models were established based on the MRI imaging features of the fat suppression T2 weighted image (T2WI) sequence, dynamic
contrast-enhanced (DCE)-T1WIsequence and joint sequences. The T-test and the least absolute shrinkage and selection operator (LASSO)
algorithm were used for feature dimensionality reduction and screening, respectively, and the random forest (RF) algorithm was used to construct
the classification model.

Results:
The model established by the LASSO-RF algorithm was used in the ROC curve analysis. In predicting the low expression state of HER2 in breast
cancer, the radiomics models of the fat suppression T2WI sequence, DCE-T1WI sequence, and the combination of the two sequences showed
better predictive efficiency. In the receiver operating characteristic (ROC) curve analysis for the verification set of low, negative, and positive
HER2 expression, the area under the ROC curve (AUC) value was 0.81, 0.72, and 0.62 for the DCE-T1WI sequence model, 0.79, 0.65 and 0.77 for
the T2WI sequence model, and 0.84, 0.73 and 0.66 for the joint sequence model, respectively. The joint sequence model had the highest AUC
value.

Conclusions:
The MRI radiomics models can be used to effectively predict the HER2 expression in breast cancer and provide a non-invasive and early assistant
method for clinicians to formulate individualized and accurate treatment plans.
Herbal Interactions with Cardiac Medications: A Comprehensive Review of Potential Interactions between Herbal Drugs and Commonly Prescribed
Cardiac Medications
Authors: Jyothi M. Vijaya , VL Ashoka Babu , Wagh Vijay D , Rasheed Azhar , Dayaramani Richa , Panigrahy Uttam Prasad , Wal Pranay , Gunjal Sachinkumar Dnyaneshwar 
Published: May 2024

Background:
The concomitant use of herbal remedies in conjunction with conventional
cardiac medications has increased significantly in recent years, primarily due to improvements in the
quality standards of herbal medicines and the pervasive belief that natural products pose no harm to
the human body. Contrary to this belief, multiple phytoconstituents found in herbal products have the
potential to interact with conventional cardiac drugs, potentially resulting in severe adverse effects.

Objective:
This review aimed to elucidate the intricacies of these interactions highlighting herbal
medications that interact with established pharmaceuticals used for the treatment of cardiovascular
disorders. Moreover, the review draws attention to safety concerns and preventative steps that should
be taken by patients and medical professionals.. This endeavor is vital to avert adverse events stemming
from such interactions.

Methods:
Our approach entailed a comprehensive literature review employing keywords such as "mechanisms
of herb-drug interactions,” "herbal medications,” and "cardiovascular disorders.” The drugs presented
in this review were selected based on their popularity among the general population, frequency of
their employability, and potential to manifest drug interactions. We sourced pertinent information from
reputable databases, including PubMed, Scopus, and Elsevier.

Results:
Heart or blood vessel disorders are referred to as cardiovascular diseases (CVDs), which include
conditions such as heart failure, stroke, hypertensive heart disease, and peripheral arterial disease.
The primary underlying factor for the development of CVDs is dyslipidemia, which can be
treated with classical antihyperlipidemic drugs such as statins, ezetimibe, and PCSK9-inhibitors. The
use of herbal remedies is often unregulated, and there is a lack of scientific evidence supporting their
use, particularly in the management of heart failure. Patients may not disclose their use of herbal remedies
to health care practitioners, which can result in potential harm.

Conclusion:
Uncontrolled dyslipidemia leads to hypercholesterolemia, which can result in atherosclerotic
plaques and blocked arteries and veins. Herbal remedies and botanical products are also used to
prevent or treat illnesses, and many prescription pharmaceuticals are made from plant compounds.
Herbal remedies are often preferred because of the belief that they are safe and have no potential to
cause harm. However, there is insufficient scientific data to support the use of herbal remedies, especially
when treating heart disease. Using herbal remedies in conjunction with medicinal pharmaceuticals
may result in unfavorable effects.
Structure-Based Virtual Screening Identifying Novel FOXM1 Inhibitors as the Lead Compounds for Glioblastoma
Authors: Swati Kumari , Srivastava Rashi , Agrawal Kirti , Panda Siva Prasad , Parkash Anand , Kumar Dhruv , Chen Hailiang 
Published: May 2024

Background:
Glioblastoma multiforme (GBM) is a highly heterogeneous brain tumor
with limited treatment options and a poor prognosis. Cancer stem cells (CSCs) have emerged as a
critical factor in GBM resistance and management, contributing to tumor growth, heterogeneity,
and immunosuppression. The transcription factor FOXM1 has been identified as a key player in
the progression, spread, and therapy resistance of various cancers, including GBM.

Objective:
In this research, the objective was to perform structure-based in silico screening with
the aim of identifying natural compounds proficient in targeting the DNA-binding domain (DBD)
of the FOXM1 protein.

Methods:
In this study, in silico tools were employed for screening a hundred naturally occurring
compounds capable of targeting the FOXM1 protein. Through molecular docking analysis and
pharmacokinetic profiling, five compounds were found to be promising candidates for extensive
interaction with the FOXM1 protein. Further, these compounds were validated for the stability of
the FOXM1-natural compound complex using molecular dynamics (MD) simulations.

Results:
Four compounds, such as Withaferin A, Bryophyllin A, Silybin B, Sanguinarine and
Troglitazone (control compound), emerged as promising candidates with substantial interactions
with FOXM1, suggesting their potential as a protein inhibitor based on molecular docking investigations.
After MD simulation analysis, the FOXM1- Bryophyllin A complex was found to maintain
the highest stability, and the other three ligands had moderate but comparable binding affinities
over a period of 100 ns.

Conclusion:
This study provides valuable insights into four promising FOXM1 inhibitors that
have the ability to induce senescence in GBM stem cells. These findings contribute to the development
of structure-based designing strategies for FOXM1 inhibitors and innovative therapeutic approaches
for the treatment of Glioblastoma.
From Conventional to Cutting-edge: A Comprehensive Review on Drug Delivery Systems
Authors: Vikal Akash , Maurya Rashmi , Bhowmik Shuvadip , Patel Preeti , Gupta Ghanshyam Das , Kurmi Balak Das 
Published: May 2024

:
The essential need for efficacious conveyance of therapeutics to specific tissues or cells, refinement of drug formulations, and the scalability of industrial production drives the pre-sent-day demand for enhanced drug delivery systems (DDS). Newly devised drugs often exhibit suboptimal biopharmaceutical properties, resulting in diminished patient adherence and adverse side effects. The paramount importance of site-specific drug delivery lies in its capacity to facili-tate the targeted administration of diverse therapeutic agents, catering to both localized ailments and systemic treatments. Alongside targeted drug delivery strategies encompassing ligand-based targeting and stimuli-responsive systems, the advent of cutting-edge nanotechnologies such as nanoparticles, liposomes, and micelles has marked a paradigm shift. Additionally, personalized medicines have emerged as a consequential facet of drug delivery, emphasizing the customization of treatment approaches. Researchers have explored an excess of methodologies in the advance-ment of these formulation technologies, including stimuli-responsive drug delivery, 3D printing, gene delivery, and various other innovative approaches. This comprehensive review aims to pro-vide a holistic understanding of the past, present, and future of drug delivery systems, offering in-sights into the transformative potential of emerging technologies.
Biological Potential and Therapeutic Effectiveness of Phytoproduct ‘Fargesin’ in Medicine: Focus on the Potential of an Active Phytochemical of Magnolia fargesii
Authors: Patel Kanika , Patel Dinesh Kumar 
Published: May 2024

:
Flos Magnoliae is one of the important medicinal plants in different traditional
medicine, including Chinese herbal medicine. Lignans and neolignans, including tetrahydrofurofuran,
tetrahydrofuran, and aryltetralin, are present in the Flos Magnoliae species. A wide range of
pharmacological activity of Flos Magnoliae has been reported in medicine. Fargesin has been isolated
from Magnolia fargesii and is a lignan-class phytochemical. Fargesin has numerous pharmacological
activities in medicine, including its effectiveness on lipid and glucose metabolism, oxidative
stress, myocardial apoptosis, etc. In the present work, we have summarized the detailed scientific
information of fargesin concerning its medicinal properties and pharmacological activities.
Numerous biological and chemical aspects of fargesin are discussed here, including the detailed
pharmacological activities and analytical aspects of fargesin. In this review, we have also
compiled analytical data on fargesin based on available scientific literature. Ethnopharmacological
information on fargesin was gathered by a literature survey on Pubmed, Science Direct, Google,
and Scopus using the terms fargesin, Flos Magnoliae, phytochemical, and herbal medicine. The
present review paper compiled the scientific data on fargesin in medicine for its pharmacological
activities and analytical aspects in a very concise manner with proper citations. The present work
signified the biological importance of fargesin in medicine due to its significant impact on bone disorders,
lung injury, colon cancer, atherosclerosis, neurological disorders, ischemia, sars-cov-2, allergy,
lipid and glucose metabolism, melanin synthesis, and different classes of enzymes. Furthermore,
fargesin also has anti-inflammatory, antihypertensive, antiprotozoal, antimycobacterial, and
antifeedant activity. However, analytical methods used for the separation, identification and isolation
of fargesin in different biological and non-biological samples were also covered in the present
review. The present work revealed the pharmacological activities and analytical aspects of fargesin
in medicine and other allied health sectors.
Understanding the Origins of Quark Charges, Quantum of Magnetic Flux,
Planck’s Radiation Constant and Celestial Magnetic Moments with the 4G
Model of Nuclear Charge
Authors: Seshavatharam Utpala Venkata Satya , Lakshminarayana Sreerama 
Published: May 2024

Introduction:
In our previous published papers, considering 3 large atomic gravitational
constants assumed to be associated with weak, strong and electromagnetic interactions, we
have proposed the existence of a nuclear charge of magnitude, en=2.95e and developed a nuclear
mass formula associated with strong and weak interactions having 4 simple terms and only one
energy coefficient.

Methods:
Two important assumptions are that there exists a weak fermion of rest energy 585 GeV
and a strong coupling constant is the squared ratio of electromagnetic charge and nuclear charge.
The aim of this paper is associated with understanding the mystery of the quantum of magnetic
flux, Planck’s quantum radiation constant and Reduced Planck’s constant. Proceeding further,
quark charges, strong coupling constant, nuclear stability, nuclear binding energy, medium and
heavy atomic X-ray levels and celestial magnetic moments can be understood in a unified approach.
It may also be noted that, by considering the integral nature of elementary particle masses,
it seems possible to understand the discreteness of angular momentum.

Results:
Considering our proposed en=2.95e=3e as a characteristic nuclear charge, it seems possible
to understand the integral nature of quarks electromagnetic charge. With this idea, neutron,
proton and pion decay can be understood very easily.

Conclusion:
In all the cases, the up quark of charge (±2e) seems to play a crucial role in the internal
transformation of the down quark of charge (±e) and external observable elementary basic
elementary particles. It needs further study at the fundamental level.
Effects of a Serious Game for Adolescent Mental Health on Cognitive Vulnerability: Pilot Usability Study
Authors: De Jaegere Eva , van Heeringen Kees , Emmery Peter , Mommerency Gijs , Portzky Gwendolyn 
Published: May 2024

Abstract

Background
Adolescent mental health is of utmost importance. E-mental health interventions, and serious games in particular, are appealing to adolescents and can have beneficial effects on their mental health. A serious game aimed at improving cognitive vulnerability (ie, beliefs or attitudes), which can predispose an individual to mental health problems, can contribute to the prevention of these problems in adolescents.

Objective
This study aimed to assess the feasibility of the prototype of a serious game called “Silver.”

Methods
The prototype of the serious game was developed using a user-centered participatory design. The prototype of Silver focused on 1 aspect of a serious game for improving cognitive vulnerability in adolescents, that is, the recognition and identification of cognitive distortions. Through the game, players were required to identify and classify the character’s thoughts as helpful or unhelpful. Upon successful advancement to the next level, the task becomes more challenging, as players must also identify specific types of cognitive distortions. A pre- and posttest uncontrolled design was used to evaluate the game, with a 1-week intervention phase in which participants were asked to play the game. Participants aged 12-16 years were recruited in schools. The outcomes of interest were the recognition of cognitive distortions and presence of participants’ cognitive distortions. The game was also evaluated on its effects, content, and usefulness.

Results
A total of 630 adolescents played Silver and completed the assessments. Adolescents were significantly better at recognizing cognitive distortions at the pretest (mean 13.09, SD 4.08) compared to the posttest (mean 13.82, SD 5.09; t629=−4.00, P<.001). Furthermore, their cognitive distortions decreased significantly at the posttest (mean 38.73, SD 12.79) compared to the pretest (mean 41.43, SD 10.90; t629=7.98, P<.001). Participants also indicated that the game helped them recognize cognitive distortions. Many participants considered the game appealing (294/610, 48.2%) but boring (317/610, 52%) and preferred a more comprehensive game (299/610, 49%).

Conclusions
Findings from this study suggest that a serious game may be an effective tool for improving cognitive vulnerability in adolescents. The development of such a serious game, based on the prototype, is recommended. It may be an important and innovative tool for the universal prevention of mental health problems in adolescents. Future research on the effects of the game is warranted.