bluuebunny/crossref_metadata_2025_split huggingface dataset:
Teaching for Change: Learning Partnerships and Epistemological Growth
Authors: Olsen Deborah , Bekken Barbara M. , McConnell Kathryne Drezek , Walter Charles T. 
Published: November 2011

AbstractBaxter Magolda's Learning Partnerships model was used to create a program designed to foster student epistemological development. To assess its effectiveness, the Measure of Epistemological Reflection was administered to the experimental cohort and a comparable group in the traditional general education program. Results indicate that the model enhanced epistemological growth.
Engineering of Complex Macroporous Materials Through Controlled Electrodeposition in Colloidal Superstructures
Authors: Heim Matthias , Reculusa Stéphane , Ravaine Serge , Kuhn Alexander 
Published: November 2011

AbstractMacroporous materials with a sophisticated architecture are obtained by electrochemical deposition of gold or polypyrrole in colloidal‐crystal templates. The Langmuir–Blodgett technique enables assembly of sub‐micrometric silica‐particle monolayers on conductive gold substrates, thus leading to colloidal superstructures with an unprecedented control of their features at the single‐bead‐layer level. This allows the integration of deliberate planar defects or the elaboration of well‐defined gradients in terms of sphere size. Controlled infiltration using electrochemical deposition preserves the architecture of the original templates and leads to inverse opals with well‐defined pore structures after the removal of the inorganic particles.
Stereoselective Epoxidation of Alkenes with Hydrogen Peroxide using a Bipyrrolidine‐Based Family of Manganese Complexes
Authors: Garcia‐Bosch Isaac , Gómez Laura , Polo Alfonso , Ribas Xavi , Costas Miquel 
Published: November 2011

AbstractNovel manganese complexes containing N4‐tetradentate ligands derived from chiral bipyrrolidinediamines catalyze the stereoselective epoxidation of a wide array of alkenes using low catalyst loadings (0.1 mol%) and hydrogen peroxide (1.2 equiv.) as terminal oxidant. This family of catalysts affords good to excellent yields (80–100%) and moderate to good ees (40–73%) in short reaction times (30 min) making efficient use of hydrogen peroxide.
Ermittlung ausgewählter mechanischer Kennwerte thermisch modifizierter Buche
Authors: Wetzig Melanie , Heldstab Corina , Tauscher Tom , Niemz Peter 
Published: November 2011

AbstractUntersuchungen zu physikalisch‐mechanischen und chemischen Eigenschaften thermisch modifizierten Holzes sind bereits seit den frühen 1950er Jahren durchgeführt und wieder verstärkt in den letzten zehn bis zwanzig Jahren aufgenommen worden. Generelle Zusammenhänge zwischen den Behandlungsparametern und den Eigenschaften des vergüteten Holzes sind weitgehend bekannt. Gegenstand und Ziel der vorliegenden Untersuchungen war die Ermittlung ausgewählter mechanischer Kennwerte von im Autoklaven nach zwei unterschiedlichen Verfahren thermisch behandeltem Buchenholz. Die Resultate zeigen, dass die Zug‐ und Druckfestigkeit sowie der Elastizitäts‐ und Schubmodul im Vergleich zum unbehandelten Referenzholz um bis zu 50 % sinken. Die Zugfestigkeit wurde dabei stärker beeinträchtigt als die Druckfestigkeit.Determination of select mechanical properties of heat‐treated beech wood. Studies on mechanical and chemical properties of heat‐treated wood have been conducted since the early 1950ies. General interrelationships between process parameters and properties of heat‐treated wood are reasonably well known. The present study deals with select mechanical properties of heat‐treated beech wood in the autoclave in two different treatment atmospheres. The results show, that the tensile and compression strength as well as modulus of elasticity and modulus of rigidity decrease about 50 % compared to untreated wood. The tensile strength was less affected by the treatment than the compression strength.
Dreidimensionale Berechnungsmodelle zur Bemessung einer ovalen, tiefen Baugrube bei schwierigen geotechnischen Randbedingungen
Authors: Raithel Marc , Kirchner Andreas 
Published: November 2011

AbstractIm Zuge der Erweiterung des Rheinkraftwerks Iffezheim, einem Gemeinschaftskraftwerk der EnBW Kraftwerke AG und EDF Electricité de France, mit Einbau einer fünften Rohrturbine ist die Herstellung von drei Baugruben erforderlich, die Oberwasser‐Baugrube (Einlauf), die Hauptbaugrube (Kraftwerk) und die Unterwasser‐Baugrube (Saugschlauch und Auslauf). Sämtliche Baugruben befinden sich innerhalb einer an das bestehende Kraftwerk anschließenden Erweiterung des vorhandenen Querbauwerks (Damm). Die Hauptbaugrube (HBG) mit den Abmessungen von 51 m auf 36 m und einer Aushubtiefe von ca. 34 m ist dabei eine ovale Baugrube (korbbogenförmige Baugrube) ohne Steifen und Rückverankerung der Baugrubenwände. Aufgrund der Form der HBG und der asymmetrischen und Belastungsrandbedingungen war im Zuge der Ausführungsplanung die Erstellung von komplexen dreidimensionalen numerischen Berechnungsmodellen erforderlich, wobei das räumliche Tragverhalten der Baugrube zutreffend zu berücksichtigen war.3D calculation models for the design of an oval, deep excavation pit under difficult geotechnical circumstances. In the course of the expansion of the existing Rheinkraftwerk Iffezheim (i.e. running‐water power station in Iffezheim), a companionship of the EnBW Kraftwerke AG and EDF Electricité de France, three excavation pits are required to install the fifth bulb turbine: the uptstream excavation pit (entry), the main excavation pit (power plant) and the downstream excavation pit (siphon pipe and exit). All three excavation pits are in the middle of an artificial island which is connected to the existing power plant. The main excavation (dimensions 51 m to 36 m, excavation depth appr. 34 m) is an oval (ellipsoidal) excavation pit without struts and rear anchorage of the pit walls. Because of the shape of the main excavation pit and the asymmetric geometric and load boundary conditions, a complex three‐dimensional numeric model for the calculations was needed which was able to take into account the special structural behavior of the excavation pit appropriately.
Beitrag zum Entwurf und zur Ausführung von kombinierten Pfahl‐Plattengründungen
Authors: Grabe Jürgen , Pucker Tim 
Published: November 2011

AbstractEs wird ein Modell zur Berechnung der zu erwartenden Setzungen einer kombinierten Pfahl‐Plattengründung (KPP) vorgestellt. Das Modell berücksichtigt die Interaktionen der verschiedenen Bauteile untereinander, wie z. B. die Pfahl‐Pfahl‐Interaktion oder die Pfahl‐Platten‐Interaktion. Weiterhin werden spannungs‐ und richtungsabhängige Bodeneigenschaften, wie beispielsweise der Steifemodul und die Lastgeschichte der Gründung, berücksichtigt.Mit Hilfe eines Evolutionären Algorithmus wird eine beispielhafte kombinierte Pfahl‐Plattengründung optimiert. Ziel der Optimierung ist die Reduktion der Kosten und der Setzungen der Gründung. Es wird gezeigt wie dem entwerfenden Ingenieur eine Entscheidungshilfe anhand eines fallspezifischen Zusammenhangs zwischen Kosten und Setzungen gegeben werden kann.Während der Ausführung verändert die Herstellung der Pfähle die Bodenzustandsgrößen in der Umgebung der Pfähle. Es wird beispielhaft aufgezeigt, wie diese Einflüsse abgeschätzt werden können und welche Konsequenzen diese für das Setzungsverhalten der KPP haben.Article about design and building of combined pile‐raft foundations. A calculation model to predict the settlement of combined pile‐raft foundations is presented. This model takes account of interactions between the building elements, e.g. the pile‐to‐pile or the pile‐to‐raft interaction. Additionally, stress and direction depending soil properties are taken into account, e.g. the soil stiffness or the loading history.An evolutionary algorithm is used to optimize an exemplary combined pile‐raft foundation. Using this optimization method, the total costs and settlement of the foundation are reduced. A case specific correlation between total costs and settlement is presented. Hence this correlation can be used by the design engineer as a decision support.During the installation process of the foundation, the soil state properties are modified. So the influence on a combined pile‐raft foundation design is presented.
Numerische Untersuchung zum Tragverhalten der Zwischenbohlen kombinierter Spundwände bei Belastung durch Wasserdruck
Authors: Pucker Tim 
Published: November 2011

AbstractIn diesem Artikel werden numerische Simulationen zum Tragverhalten der Zwischenbohlen kombinierter Stahlspundwände bei Belastung durch Wasserdruck vorgestellt. Dabei wird das Rotationsverhalten der Spundwandschlösser berücksichtigt. Die maximale Tragfähigkeit der Zwischenbohlen wird anhand der numerischen Simulationen ermittelt. Anschließend werden Stabwerksmodelle entwickelt, um die Standsicherheit der Zwischenbohlen nachweisen zu können.Numerical simulation of the bearing behavior of the secondary elements of combined sheet pile constructions under water pressure. The bearing behavior of the secondary elements of combined sheet pile constructions is investigated using numerical simulations. The secondary elements are only loaded by water pressure. The bearing capacity is determined and simplified models are developed to predict the stability of secondary elements loaded by water pressure.
Die Erdbeben in Kandel/Südpfalz von 1880 und 1903
Authors: Barth Andreas 
Published: November 2011

AbstractDie Erdbeben vom 24. Januar 1880 und 22. März 1903 sind die stärksten bekannten seismischen Ereignisse, die in der Südpfalz stattgefunden haben. Vor dem Hintergrund der erhöhten Aktivität auf dem Gebiet der tiefen Geothermie ist eine Neubewertung der historischen Beben von allgemeinem Interesse. Die Auswertung historischer Literaturquellen zeigt, dass das Erdbeben von 1880 eine Maximalintensität von I0 = V (nach EMS‐98) erzeugte, während das Ereignis von 1903 I0 = VI aufwies. Damit wurden beide Beben in der bisherigen Literatur um einen halben bzw. einen Intensitätsgrad überbewertet, was folglich zu einer Überschätzung der Magnitude führte. Aus den deutlich unterschiedlichen Spürbarkeitsradien beider Beben (49 km bzw. 30 km) und der Neubewertung der Intensität ergibt sich für das 1880er Beben eine Magnitude von ML 3,7 (MW 3,3) bei einer Herdtiefe von 14 km und für das 1903er Beben ML 3,9 (MW 3,6) bei einem sehr flachen Hypozentrum bei 2,5 km Tiefe. Die Epizentren lagen 1880 etwa 3 km nord‐nordöstlich von Kandel und 1903 in Kandel selbst.Re‐evaluation of intensity and source parameters of the earthquakes in Kandel/Southern Palatinate in 1880 and 1903. The earthquakes of 24 January 1880 and 22 March 1903 are the strongest seismic events known for the region of Southern Palatinate (Upper Rhine Graben, Germany). Regarding the increased geothermal activity the re‐evaluation of the historic earthquakes is of general interest. The analysis of the historic literature reveals a maximum intensity I0 = V (EMS‐98) for the 1880 earthquake and I0 = VI for the event of 1903. Thus, for both seismic events the maximum intensity was overestimated in recent bulletins by one half and one whole grade, respectively. As a consequence, this also led to an overestimation of the magnitudes. The remarkable difference in the radius of perceptibility of both earthquakes (49 km and 30 km, respectively) in combination with the newly assigned intensities allows to estimate the magnitude of the event in 1880 to ML 3.7 (MW 3.3) at a hypocentral depth of 14 km; for the 1903 event a magnitude of ML 3.9 (MW 3.6) results for a shallow source at 2.5 km. The epicentres were approximately 3 km N‐NE of Kandel in 1880 and directly at Kandel in 1903.
Metabolic network modeling and simulation for drug targeting and discovery
Authors: Kim Hyun Uk , Sohn Seung Bum , Lee Sang Yup 
Published: November 2011

AbstractSystems biology has greatly contributed toward the analysis and understanding of biological systems under various genotypic and environmental conditions on a much larger scale than ever before. One of the applications of systems biology can be seen in unraveling and understanding complicated human diseases where the primary causes for a disease are often not clear. The in silico genome‐scale metabolic network models can be employed for the analysis of diseases and for the discovery of novel drug targets suitable for treating the disease. Also, new antimicrobial targets can be discovered by analyzing, at the systems level, the genome‐scale metabolic network of pathogenic microorganisms. Such applications are possible as these genome‐scale metabolic network models contain extensive stoichiometric relationships among the metabolites constituting the organism's metabolism and information on the associated biophysical constraints. In this review, we highlight applications of genome‐scale metabolic network modeling and simulations in predicting drug targets and designing potential strategies in combating pathogenic infection. Also, the use of metabolic network models in the systematic analysis of several human diseases is examined. Other computational and experimental approaches are discussed to complement the use of metabolic network models in the analysis of biological systems and to facilitate the drug discovery pipeline.
Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell‐cytokine interactions
Authors: Morris Melody K. , Shriver Zachary , Sasisekharan Ram , Lauffenburger Douglas A. 
Published: November 2011

AbstractMathematical models have substantially improved our ability to predict the response of a complex biological system to perturbation, but their use is typically limited by difficulties in specifying model topology and parameter values. Additionally, incorporating entities across different biological scales ranging from molecular to organismal in the same model is not trivial. Here, we present a framework called “querying quantitative logic models” (Q2LM) for building and asking questions of constrained fuzzy logic (cFL) models. cFL is a recently developed modeling formalism that uses logic gates to describe influences among entities, with transfer functions to describe quantitative dependencies. Q2LM does not rely on dedicated data to train the parameters of the transfer functions, and it permits straight‐forward incorporation of entities at multiple biological scales. The Q2LM framework can be employed to ask questions such as: Which therapeutic perturbations accomplish a designated goal, and under what environmental conditions will these perturbations be effective? We demonstrate the utility of this framework for generating testable hypotheses in two examples: (i) a intracellular signaling network model; and (ii) a model for pharmacokinetics and pharmacodynamics of cell‐cytokine interactions; in the latter, we validate hypotheses concerning molecular design of granulocyte colony stimulating factor.
Production of glucuronic acid‐based polysaccharides by microbial fermentation for biomedical applications
Authors: Cimini Donatella , De Rosa Mario , Schiraldi Chiara 
Published: November 2011

AbstractThis review provides an overview of the properties, different biosynthetic machineries, and biotechnological production processes of four microbially derived glucuronic acid‐based polysaccharides that are of interest for diverse biomedical purposes. In particular, the utilization of hyaluronic acid and heparin sulfate in high‐value medical applications is already well established, whereas chondroitin sulfate and alginate show high potential within this ever‐growing field. Furthermore, new strategies exploiting genetically engineered microorganisms generated through improving naturally existing pathways or de novo designed ones are described. These new developments result in increased fermentation titers, and thereby, pave the way towards feasible, or at least improved, process economy. Moreover, these strategies also allow for the future possibility of producing tailor‐made biopolymers with specified characteristics, even novel molecules.
Specialization and integration of brain responses to object recognition and location detection
Authors: Pennick Mark R. , Kana Rajesh K. 
Published: November 2011

AbstractVisual information is processed in the brain primarily through two distinct pathways, the dorsal and the ventral visual streams. The present functional magnetic resonance imaging study investigated the specialization and integration of dorsal and ventral streams using tasks of object recognition and location detection. The study included 22 healthy adult volunteers who viewed stimuli consisting of grayscale photographs of common household objects presented in blocked design. Participants were asked to either recognize an object or to locate its position. While the location detection task elicited greater activation in the dorsal visual stream, recognizing objects showed greater activation in the middle occipital gyri, left inferior temporal gyrus, and in the left inferior frontal gyrus. The integration between dorsal and ventral brain areas was stronger during location detection than during object recognition. In addition, a principal components analysis found preliminary evidence for a group of regions, such as frontal and parietal cortex, working together in this task. Overall, the results of this study indicate the existence of specialized modules for object recognition and location detection, and possible interactions between areas beyond the visual cortex that may play a role in such tasks.
Antioxidants in patients receiving total parenteral nutrition after gastrointestinal cancer surgery
Authors: Szpetnar Maria , Matras Przemysław , Kiełczykowska Małgorzata , Horecka Anna , Bartoszewska Lidia , Pasternak Kazimierz , Rudzki Sławomir 
Published: November 2011

Total parenteral nutrition (TPN) is essential for patients with postoperative impairing gastrointestinal function who are unable to receive and absorb oral/enteral feeding for at least 7 days. Oxidative stress plays a major role in the ethiopathogenesis of cancers. In this study, total antioxidant status (TAS), glutathione peroxidase (GPx), superoxide dismutase, malondialdehyde and ascorbic acid were studied in patients operated because of small intestine, colorectal or pancreatic cancer and subsequently receiving TPN in comparison with patients receiving standard nutrition after the operation. TAS level and GPx activity were decreased in patients with small intestine cancer but did not differ in patients with colorectal and pancreatic cancer before and after surgery. In all patient groups receiving TPN, superoxide dismutase activity after the surgery was kept at the same level as before. On the fifth day after the surgery, malondialdehyde concentration in each group was restored to the value observed before surgery. On the fifth day of TPN treatment, ascorbic acid concentration was increased in every group of patients.TPN applied during the postoperative period alleviates oxidative stress resulting from surgery. In the case of small intestine cancer, the addition of vitamins and antioxidants to the nutrition mixture seems to result in depletion of antioxidant enzymes' activities. Copyright © 2011 John Wiley & Sons, Ltd.
Mechanism‐Oriented Redesign of an Isomaltulose Synthase to an Isomelezitose Synthase by Site‐Directed Mutagenesis
Authors: Görl Julian , Timm Malte , Seibel Jürgen 
Published: November 2011

AbstractAn isomelezitose synthase was redesigned out of the sucrose isomerase from Protaminobacter rubrum for the synthesis of isomelezitose (6‐OF‐glucosylsucrose), a potential nutraceutical. The variants F297A, F297P, R333K, F321A_F319A and E428D catalyze the formation of isomelezitose in up to 70 % yield.
Interparental aggression and infant patterns of adrenocortical and behavioral stress responses
Authors: Towe‐Goodman Nissa R. , Stifter Cynthia A. , Mills‐Koonce W. Roger , Granger Douglas A. ,   The Family Life Project Key Investigators
Published: November 2011

AbstractDrawing on emotional security theory, this study examined linkages between interparental aggression, infant self‐regulatory behaviors, and patterns of physiological and behavioral stress responses in a diverse sample of 735 infants residing in predominately low‐income, non‐metropolitan communities. Latent profile analysis revealed four classes of adrenocortical and behavioral stress‐response patterns at 7 months of age, using assessments of behavioral and cortisol reactivity to an emotion eliciting challenge, as well as global ratings of the child's negative affect and basal cortisol levels. The addition of covariates within the latent profile model suggested that children with more violence in the home and children who used less caregiver‐oriented regulation strategies were more likely to exhibit a pattern of high cortisol reactivity with moderate signs of distress rather than the average stress response, suggesting possible patterns of adaptation in violent households. © 2011 Wiley Periodicals,Inc. Dev Psychobiol 54: 685–699, 2012.
Self‐Assembled Submonolayer of β‐Cyclodextrins on Gold Electrode for the Selective Determination of 4‐Aminobiphenyl
Authors: Carrillo Idania , Quintana Carmen , Esteva Ana M. , Hernández Lucas , Hernández Pedro 
Published: November 2011

AbstractThe formation of an inclusion complex between 4‐aminobiphenyl (4‐AB) and β‐cyclodextrin molecules (β‐CD), allows the use of thiolated β‐CDs as chemi‐adsorbed material on a Au electrode as a self‐assembled submonolayer for the selective square wave voltammetric determination of 4‐AB. The submonolayer was characterized by reductive desorption and an association constant of 1.2×104 L/mol was obtained. The optimization of variables yielded a linear dependence of ip/4‐AB concentration in the range of 10−5 to 10−4 mol/L. The selectivity of the method was evaluated in the presence of other aromatic amines obtaining better results with the modified electrode. This methodology was applied to the voltammetric determination of 4‐AB in wastewater samples.
Application of Modified Tafel Analysis to the Identification of Corrosion Products on Archaeological Metals Using Voltammetry of Microparticles
Authors: Doménech Antonio , Doménech‐Carbó María Teresa , Pasies Trinidad , Bouzas María Carmen 
Published: November 2011

AbstractAn operational modification of Tafel analysis, applied to the intermediate region of square wave voltammetric curves, devoted to the identification of corrosion products on archaeological metal, is described. This is based on the voltammetry of microparticles methodology using conventional abrasive conditioning of the electrode, as well as ‘one‐touch’ and layer‐by‐layer techniques. The proposed methodology is applied to the identification of copper and silver corrosion products in mediaeval silver‐copper coins from the Libertad street hoard in Valencia (Spain).