bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional infrared thermography imaging can be used to assess the effectiveness of Maxicam Gel® in pre-emptively treating transient synovitis and lameness in horses
Authors: Carvalho Júlia Ribeiro Garcia de , Del Puppo Debora , Littiere Thayssa de Oliveira , Sales Nathali Adrielli Agassi de , Silva Ana Carolina Yamamoto , Ribeiro Gesiane , Almeida Ferdinando Nielsen de , Alves Bruna Gomes , Gatto Igor Renan Honorato , Ramos Gabriel Vieira , Ferraz Guilherme de Camargo 
Published: June 2024

IntroductionDiagnosing and treating lameness in horses is essential to improving their welfare. In equine orthopedic practice, infrared thermography (IRT) can indirectly detect soreness. Non-steroidal anti-inflammatory drugs can treat painful and inflammatory processes in horses. Using IRT, the efficacy of meloxicam (Maxicam Gel®) was evaluated in pre-treating transient synovitis in horses induced by a middle carpal joint injection of lipopolysaccharides (LPS) from E. coli 055:B5 at a dose of 10 endotoxin units.MethodsIn a cross-over design, six healthy horses were randomly assigned to receive either 0.6 mg/kg of oral Maxicam Gel® (MAXVO) or a mock administration (control group, C) following a two-week washout period. IRT of the middle carpal joint, visual lameness assessment and joint circumference were recorded over time. Clinical and hematological evaluations were performed. Synovial fluid aspirates were analyzed for total nucleated cell count, total protein, and prostaglandin E2. A mixed effects analysis of variance was performed for repeated measures over time, followed by Tukey’s test. A multinomial logistic regression was conducted to determine whether there is a relationship between a thermography temperature change and the lameness score.ResultsThere were no changes in joint circumference. The MAXVO group showed a lower rectal temperature 4 h after synovitis induction. The C group presented an increase in neutrophils and a decrease in total hemoglobin and hematocrit 8 h after induction. No changes were observed in the synovial fluid between groups. The horses that received meloxicam did not show clinically significant lameness at any time, while the C group showed an increase in lameness 2, 4, and 8 h after synovitis induction.DiscussionIRT indicated that the skin surface temperature of the middle carpal joint was lower in horses who received meloxicam, suggesting a reduction in the inflammatory process induced by LPS. It was observed that the maximum temperature peaks in the dorsopalmar and lateropalmar positions can be utilized to predict the severity of lameness, particularly when the temperature rises above 34°C. Horses pre-treated with meloxicam showed either reduced or no indication of mild to moderate pain and presented a lowehr thermographic temperature, which indicates the effectiveness of Maxicam Gel® as an anti-inflammatory.
Hammering nails with a screwdriver: how GPs perceive video consultations
Authors: Wanderås Magnus Repstad , Abildsnes Eirik , Thygesen Elin , Martinez Santiago Gil 
Published: June 2024

Background
Early in the COVID-19 pandemic, the use of video consultation (VC) expanded considerably, with GPs indicating high satisfaction with it. However, use of VC declined as lockdown measures were eased.

Aim
To explore reasons why VC use has declined in Norwegian general practice since the start of the pandemic by investigating GPs’ experiences with VC and their attitudes towards it in a post-pandemic setting.

Design & setting
Qualitative study using semi-structured interviews with 13 GPs in southern Norway between May 2022 and March 2023.

Method
Data analysis was conducted by applying the six steps of Braun and Clarke’s reflexive thematic analysis.

Results
Although the implementation of VCs was unplanned, most participants were able to use this modality without much problem. Several GPs initially envisioned long-term VC use. However, despite certain positives, VCs were largely sidelined in favour of face-to-face and telephone consultations, owing to their practicality and VC’s limited usefulness when considering the extra effort required. Nonetheless, GPs recognised ways of using VC that might exploit its strengths, but they highlighted how its sustained use would require them to replace other consultation modalities. They also identified extrinsic factors that might lead to the increased use of VC, including improved VC technology and patient demand.

Conclusion
Although VC is now part of many GPs’ consultation toolboxes, its perceived relative lack of usefulness and extra effort compared with other remote consultation modalities mean that most GPs have chosen to abandon it as a routine consultation modality.
Frequência escolar nos cursos da Polícia Militar do Paraná: uma análise das divergências regulatórias da portaria de ensino da PMPR
Authors: Jonck Romário José , Santana Ana Maria da Silva Delai 
Published: June 2024

O presente artigo destaca a importância da frequência escolar nos cursos de formação da Polícia Militar do Paraná (PMPR) e analisa as implicações das divergências regulatórias nos limites de faltas justificadas estabelecidos na norma interna da instituição. A frequência escolar é fundamental para o sucesso acadêmico e profissional dos alunos, proporcionando não apenas a absorção contínua de conhecimento, mas também a interação com colegas e professores, enriquecendo assim a experiência de aprendizagem. O texto contextualiza a legislação nacional sobre frequência escolar, destacando a exigência de uma frequência mínima de 75% para aprovação nos níveis fundamental e médio, e a tendência de estabelecer o mesmo padrão nos cursos de formação, como àqueles oferecidos pela PMPR. No entanto, ao analisar detalhadamente a norma interna da instituição, observa-se uma discrepância entre os limites de faltas justificadas permitidas, o que pode resultar em inconsistências na aplicação das normas de frequência escolar. A existência de diferentes limites de faltas permitidas pode levar a interpretações conflitantes e tratamentos desiguais dos alunos, comprometendo a equidade no processo educacional. Além disso, a falta de clareza e uniformidade nos procedimentos para abono de faltas e matrícula em cursos pode gerar dúvidas e inconsistências na aplicação das regras. Diante dessas divergências, o artigo propõe medidas para resolver o problema e garantir a consistência e equidade na aplicação das normas de frequência. Uma solução viável seria revisar os artigos em questão, alinhando os limites de faltas justificadas com os padrões nacionais estabelecidos pela legislação educacional e pela Matriz Curricular Nacional para a Segurança Pública. Além disso, é importante especificar os critérios para abono de faltas excepcionais, garantindo transparência e equidade no tratamento dos alunos. Ao adotar essas medidas, a PMPR poderá promover uma gestão educacional mais eficaz, assegurando a qualidade e equidade no processo de formação dos policiais militares.
The Abuse and Neglect Matrix: Factors Influencing Intrapersonal and Interpersonal Abuse and Neglect
Authors: Mensah Grace Aba , Quainoo Eric Atta , Gyamfi Abraham 
Published: June 2024

Factors influencing intrapersonal and interpersonal abuse, neglect, and quality of life have not received much attention from scholars. Few studies on intrapersonal and interpersonal abuse and neglect have focused on employees in organisations without addressing the problem from children or students’ points of view. In light of this knowledge, the current study used a socio-ecological perspective to illustrate the factors that influence both intrapersonal and interpersonal abuse and neglect. These factors can be attributed to family structure, individual factors, macrosystem factors, contextual factors, quality of life, and emotional abuse.
La déconstruction du stéréotype de la vieillesse dans l’œuvre de Vladimir Makanin
Authors: Després Isabelle 
Published: June 2024

Vladimir Makanin (1937-2017) est le représentant d’un nouveau réalisme littéraire. Dans ses récits et romans, il revient constamment sur certains thèmes et motifs, de sorte que l’on peut parler d’un métatexte. Un de ces motifs récurrents est celui de la vieillesse. La figure du vieillard est communément associée, sur le plan sémantique, à la faiblesse, la maladie et l’approche de la mort, par opposition à celle de l’homme jeune qui, particulièrement dans le mythe soviétique, est beau, fort, travailleur et joyeux. Le métatexte de Makanin déconstruit le stéréotype qui ressort des associations langagières communes, tout d’abord par l’érotisation des corps des vieux (dans Les Voix), puis par une réflexion sur le tragique de la perte du pouvoir (politique autant que sexuel), sur la responsabilité et la culpabilité, sur le renoncement (dans La guerre d’un jour). Enfin, Makanin construit dans La frayeur un personnage qui s’inscrit dans la lignée du « petit homme » de la littérature russe, celui du vieillard Alabin. Cet alter ego de l’auteur est considéré par la société comme « inadéquat », c’est à dire inapte et marginal, mais l’auteur combine ce regard extérieur avec le point de vue du personnage lui-même, qui ne cesse de manifester son désir érotique, son énergie vitale, sa capacité d’agir et sa liberté. Ainsi, s’écartant des canon moderniste et réaliste, Makanin interroge et retourne les associations traditionnelles de la vieillesse avec la solitude, la faiblesse, l’incapacité et la folie et en propose plusieurs regards, parfois contradictoires. N’hésitant pas à bousculer le lecteur, il l’invite à un décentrement et à une remise en question, en lui offrant la figure originale, paradoxale et dérangeante d’un vieillard érotomane, libéré, impliqué, et amoureux de la vie.
Investigating the Nurses and Doctors Attitudes' Regarding the Management of Acute Myocardial Infarction Patients Who Used the Thrombolytic Agents in Babylon Teaching Hospitals 2022rses and Doctors Regarding Management of Patients with Acute Myocardial Infarction Using Thrombolytic Agents in the Teaching Hospitals of Babylon, Iraq in 2022
Authors: Al-Ameri Hussein Abbas Salman , Al-Jumaili Hasan Salim Abdulsada , Rad Marzieh Ziaei 
Published: June 2024

Introduction and purpose: Ischemic heart disease and myocardial infarction are the most common causes of death in the world, and nurses play a key role in the management of these patients. Adequate attitude of health care workers towards the management of patients with acute myocardial infarction using thrombolytic agents is very important and this issue is part of patients' rights.
Aims: The present study was conducted with the aim of study investigate the attitude of nurses and doctors regarding the management of patients with acute myocardial infarction using thrombolytic agents in the teaching hospitals of Babylon, Iraq in 2022.
Research method: In this comparative study, 103 nurses and 13 doctors were selected in 2022 by available sampling method the type of sample was purposive and was conducted on nurses and doctors working in cardiac and coronary resuscitation units in Babylon Specialized Hospitals. Information was collected using two questionnaires including demographic questionnaire and attitude measurement questionnaire the attitudes questionnaire contained parts that included nurses and doctors, and a section specific to nurses only.
Results: Among the studied nurses, the largest number were university nurses (36.9% bachelor, 8.7% master). (89.3%) of the nurses had work experience in the coronary care department and (73.8%) of them were currently working in the coronary care department. (78.6%) worked in the morning shift. (76.7%) of the nurses did not have a history of passing the training course in the coronary care department. (54.4%) of the nurses have a diploma and only (2.9%) of them have completed an academic course. The score of doctor’s attitude about the management of patients with acute myocardial infarction using thrombolytic agents was in the range of 68 to 98 with a mean and standard deviation of 83.62 ± 9.62. Based on the results of the independent t-test, there was no significant difference between nurses and doctors regarding the management of patients with acute myocardial infarction using thrombolytic agents (p=0.210).
Conclusion: The study concludes that both nurses and doctors in Babylon Teaching Hospitals show a positive attitude towards managing acute myocardial infarction patients using thrombolytic agents. Despite variations in experience and training, both groups are prepared to provide effective care for these patients. The findings suggest a readiness within the medical staff to handle cases of AMI with thrombolytic therapy, highlighting the importance of continued education and training in coronary care management.
Le roi dépossédé Pierre II de Yougoslavie
Authors: Pavloviç Vojislav 
Published: June 2024

Pierre II de Yougoslavie, devint roi après le coup de 27 mars 1941, mais il ne régnait que depuis trois semaines lorsque son pays fut vaincu par l’Allemagne hitlérienne. Le jeune souverain d’à peine dix-huit ans se trouva face à un double conflit en Yougoslavie, la guerre ethnique et la guerre civile sur fond d’occupation étrangère. L’issue de la guerre en Yougoslavie fut décidée lorsqu’à Téhéran fut prise la décision d’abandonner le projet d’un débarquement dans les Balkans laissant la Yougoslavie dans la zone d’influences soviétique. Dès lors les partisans de Tito ont pu prendre le pouvoir en Yougoslavie et instaurer une dictature de type stalinien, privant le roi de son pouvoir en le forçant à l’exil permanent.
Quels modes d’ambidextrie pour la servicisation ? Une étude longitudinale en PME
Authors: Peillon Sophie 
Published: June 2024

La question du rôle de l’ambidextrie dans la servicisation des entreprises industrielles est reconnue comme primordiale tout en restant sous-étudiée. Dans cet article, nous visons à combler ce gap en analysant le cas d’une PME industrielle afin d’identifier les modes d’ambidextrie qu’elle a mobilisés au cours du temps pour soutenir le développement de ses activités de service. Nous montrons que l’exploitation et l’exploration dans le domaine des services apparaissent comme combinées et se renforçant mutuellement. Nous montrons également l’existence d’une ambidextrie « hybride » au sein de cette PME, reposant sur une combinaison des différents modes d’ambidextrie structurelle, de réseau, séquentielle, contextuelle et managériale. Cette étude permet ainsi d’enrichir à la fois la littérature sur la servicisation et sur l’ambidextrie en PME. Codes JEL : O31, O32
L’expression vocale des émotions chez le primate humain et non humain : une approche évolutive
Authors: Barkat-Defradas Melissa 
Published: June 2024

L’Humain n’a pas le monopole du cœur. Le cadre conceptuel fourni par la théorie de l’évolution de Darwin et les similarités relevées par l’auteur dans l’expression des émotions entre différentes espèces animales – dont l’humain – l’ont conduit à envisager ce phénomène universel, observé à l’échelle interspécifique, comme un continuum . Les travaux récents en éthologie et en anthropologie soutiennent l’idée que tout organisme vivant doit faire face aux mêmes défis pour survivre (recherche de nourriture, choix d’un partenaire sexuel, défense contre les agresseurs). Dans ce contexte, les différents états émotionnels (notamment la colère, la peur, la joie, la surprise et le dégoût) constituent autant de moyens adaptatifs pour y répondre. Il semble ainsi peu pertinent de séparer l’humain des autres animaux pour ce qui relève du comportement émotionnel.
Le transport ferroviaire conteneurisé entre Chine et Europe
Authors: Thorez Julien , Colin Sébastien , Savchuk Ivan 
Published: June 2024

Après le lancement de la Belt and Road Initiative (BRI), les échanges ferroviaires conteneurisés entre la Chine et l’Europe ont connu une croissance soutenue. Ce projet emblématique des « nouvelles routes de la Soie » a toutefois été récemment confronté à deux « chocs externes », la pandémie de Covid-19 en 2020 puis l’invasion de l’Ukraine par l’armée russe en 2022, dont l’article étudie les conséquences. S’inscrivant dans une démarche de géographie des transports, l’analyse met notamment en évidence les effets contraires de ces événements sur le trafic transcontinental, en hausse pendant la pandémie et en recul depuis le début de la guerre, et révèle le basculement vers l’Asie de l’activité de China Railway Express .
Histoire monétaire du monde romain
Authors: Hostein Antony 
Published: June 2024

Programme de l’année 2022-2023 : I. La province d’Asie sous les Antonins et les Sévères : approche numismatique. L’Ionie (suite) et les Cyclades (4). — II. Monnaie et société dans l’Afrique romaine. — III. Actualité de la recherche.
Histoire des sciences dans l’Occident médiéval
Authors: Weill-Parot Nicolas 
Published: June 2024

Programme de l’année 2022-2023 : I. Une voie originale pour la philosophie naturelle en Angleterre ? La Summa logicae et philosophiae naturalis (v. 1335-1349) de John Dumbleton. — II. Autour du calcul rénal : médecine, chirurgie et magie.
Culture et vulgarisation dans la France médiévale
Authors: Ducos Joëlle 
Published: June 2024

Programme de l’année 2021-2022 : I. Approches d’une traduction en français médiéval : méthodes et outils autour d’un corpus du XIVe siècle. — II. Culture(s) philosophique(s) et laïcs (XIIIe-XVe siècles).Programme de l’année 2022-2023 : I. « Bailler science en françois » : le lexique comme initiation aux savoirs (XIIe-XVe siècles). — II. Culture(s) philosophique(s) et laïcs (XIIIe-XVe siècles).
Endoplasmic Reticulum Stress Response Mediator IRE-1α Promotes Host Dendritic Cells in Graft-versus-Host Disease Development
Authors: Choi Hee-Jin , Wu Yongxia , McDaniel Mims Brianyell , Pugel Allison , Tang Chih-Hang Anthony , Tian Linlu , Hu Chih-Chi Andrew , Yu Xue-Zhong 
Published: June 2024

Abstract
Allogeneic hematopoietic cell transplantation is an effective treatment for hematologic malignancies, but the complications such as graft-versus-host disease (GVHD) can limit its benefit. The conditioning regimens before transplant, including chemotherapy or irradiation, can trigger endoplasmic reticulum stress. IRE-1α is a major endoplasmic reticulum stress mediator that can further activate both spliced XBP-1 (XBP-1s) and regulated IRE-1–dependent decay (RIDD). IRE-1α–XBP-1s signaling controls dendritic cell (DC) differentiation and Ag presentation, crucial in GVHD progression. In this study, we used DC-specific XBP-1–deficient mice as donors or recipients and observed that XBP-1s was crucial for host DCs in the induction of GVHD but dispensable for the graft-versus-leukemia response. To specifically target IRE-1α in the host, we treated recipient mice with the IRE-1α inhibitor B-I09 for 3 d prior to bone marrow transplantation, which significantly suppressed GVHD development while maintaining the graft-versus-leukemia effect. XBP-1–deficient or BI09-treated recipients showed reduced DC survival after irradiation and bone marrow transplantation. Inhibition of IRE-1α also led to a reduction in DC alloreactivity, subsequently decreasing the proliferation and activation of allogeneic T cells. With further study using RIDD-deficient DCs, we observed that RIDD was also required for optimal DC activation. Taken together, XBP-1s and RIDD both promote host DC survival and alloreactivity that contribute to GVHD development.
Prognostic prediction and diagnostic role of Rspondin 1 expression in esophageal squamous cell carcinoma
Authors: Cheng Xiaoxia , Liu Jiao , Niu Danye , Zhang Changsong , Lin Yuansheng , Li Shengjun , Yang Jiao , Wen Jiangtao 
Published: June 2024

ABSTRACT

Context:
Rspondin 1 (Rspo1), a protein family member featuring secreted furin-like domains, plays a pivotal role in cancer development and exhibits a positive correlation with tumor progression. However, its expression in esophageal squamous cell carcinoma (ESCC) is still unknown.

Aims:
Here, we assessed the correlation between Rspo1 and clinicopathological features of ESCC patients, and further investigated the potential role of Rspo1 in ESCC development and clinical outcomes.

Settings and Design:
This was a pilot study.

Materials and Methods:
A total of 112 paraffin-embedded tumor samples from patients with ESCC, including 68 matched adjacent normal tissues, were collected post-surgery. Subsequently, tissue microarray (TMA) and immunohistochemistry (IHC) techniques were employed to assess the protein levels of Rspo1.

Statistical Analysis:
All statistical analyses were performed with SPSS 20.0 (SPSS, Inc., Chicago, IL).

Results:
We found that Rspo1 expression was significantly higher in ESCC than in adjacent normal tissues (P < 0.0001). Moreover, Rspo1 was highly expressed in ESCC tumor specimens and showed a significant correlation with the T classification of ESCC (P < 0.05). Additionally, our findings indicate a positive relationship between Rspo1 and survival time in ESCC. Patients exhibiting moderate to high levels of Rspo1 expression demonstrated superior survival outcomes compared to those with low expression (P = 0.0002).

Conclusions:
Our investigation has demonstrated that Rspo1 is upregulated in ESCC and exhibits a positive correlation with disease progression. Furthermore, we have observed a significant association between Rspo1 overexpression and improved patient survival rates, indicating its potential as a prognostic marker and therapeutic target for ESCC treatment.
ՄԱՆԿՈՒԹՅԱՆ ՀԻՄՆԱԽՆԴԻՐԸ ԿՐԹՈՒԹՅԱՆ ՀԱՄԱԿԱՐԳԻ ԺԱՄԱՆԱԿԱԿԻՑ ՄԱՐՏԱՀՐԱՎԵՐՆԵՐԻ ՀԱՄԱՏԵՔՍՏՈՒՄ
Authors: Գևորգյան Սրբուհի 
Published: June 2024

Հոդվածում ներկայացվել են մեր կողմից իրականացված հետազոտությունների արդյունքներից մի հատված ու տարբեր մասնագետների մոտեցումներ հետևյալ հարցերի ուղղությամբ՝ ի՞նչ է փոխվել երեխայի իմացական ոլորտում, մասնավորապես՝ մտածողության մեջ, սոցիալական վարքագծում, հուզակամային ոլորտում ըստ տարիքային փուլերի, ի՞նչ դրական և բացասական հետևանքների դրանք կարող են հանգեցնել անձի սոցիալականացման գործընթացում, ինչպ՞ես, ի՞նչ ուղղություններով վերափոխել կրթության համակարգը, ուսուցման գործընթացի մեթոդաբանությունը, որպեսզի հարմարեցնել ժամանակակից անձի զարգացման և տարիքային փոփոխություններին, կառավարել այդ զարգացումները, ապահովել նրա հաջող և ակտիվ սոցիալականացումը։ Մասնավորապես ներկայացվել են 21-րդ դարում կրտսեր դպրոցական տարիքում երեխայի իմացական, հուզակամային ոլորտներում, սոցիալական վարքագծում տեղի ունեցող փոփոխությունները։ Հետազոտություններն իրականացվել են դիտման, հացազրույցի, հրցաթերթիկային հացման և թեստերի մեթոդներով։ Հետազոտություններին մասնակցել են նախադպրոցական, դպրոցական տարիքի երեխաներ, ուսուցիչներ, մասնագետ մանկավարժներ։ Մեր կողմից կատարված հետազոտությունները փաստում են, որ ընդհանուր զարգացման տեմպերով, հոգեբանական նորագոյացությունների քանակով, դրանց դրսևորումների առանձնահատկություններով, ընդհանրական կարողունակություններով 21-րդ դարի երեխաներն առաջ են անցել նախորդ սերունդների իրենց հասակակիցներից։ Սակայն այստեղ, մեր կարծիքով, նպատակահարմար չէ միանշանակ դրական գնահատել այդ փոփոխությունները, քանի որ հոգեբանամանկավարժական տեսանկյունից առա են մի շարք խնդիրներ, որոնց մասին հանգամանորեն խոսել ենք հոդվածում։