bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupling Interaction between Precisely Located Pt Single‐Atoms/Clusters and NiCo‐Layered Double Oxide to Boost Hydrogen Evolution Reaction
Authors: Tian Yakun , Luo Yixing , Wu Tong , Quan Xinglei , Li Weiying , Wei Guangfeng , Bayati Maryam , Wu Qingsheng , Fu Yongqing , Wen Ming 
Published: April 2024

AbstractCatalysts based on Pt single atom (SA) on metal oxides have shown tremendous potentials for alkaline hydrogen evolution reaction (HER), but they are severely limited by insufficient electron interactions of Pt sites and supports. Herein, a new methodology is developed to precisely locate Pt SAs and Pt clusters into NiCo layered double oxide (LDO) nanosheets, achieved using a dual‐ion etching process with subsequent phase transformation method. Uniquely, the Pt SAs are inserted into LDO layers to form Pt─Co bonds by occupying partial Ni positions, significantly strengthening electron interactions with NiCo LDO and promoting activity of HER. Results from density functional theory calculations indicate that the H* species are preferentially absorbed onto O sites on top of these Pt SAs, which are coupled with their adjacent Pt clusters to accelerate water dissociation in the Volmer step. As‐obtained Pt─NiCo LDO exhibits a low overpotential of 92 mV at 10 mA cm−2 and a Tafel slope of 73 mV dec−1, an excellent stability over 105 hours at 60 mA cm−2, and its mass activity is 6 times higher than commercial 20% Pt/C. This study highlights essential functions of coupling interactions between Pt SAs/clusters and LDOs to boost HER for hydrogen energy production.
Bioprinting of Stable Bionic Interfaces Using Piezoresistive Hydrogel Organoelectronics
Authors: Georgopoulou Antonia , Filippi Miriam , Stefani Lisa , Drescher Felix , Balciunaite Aiste , Scherberich Arnaud , Katzschmann Robert , Clemens Frank 
Published: April 2024

AbstractBionic tissues offer an exciting frontier in biomedical research by integrating biological cells with artificial electronics, such as sensors. One critical hurdle is the development of artificial electronics that can mechanically harmonize with biological tissues, ensuring a robust interface for effective strain transfer and local deformation sensing. In this study, a highly tissue‐integrative, soft mechanical sensor fabricated from a composite piezoresistive hydrogel. The composite not only exhibits exceptional mechanical properties, with elongation at the point of fracture reaching up to 680%, but also maintains excellent biocompatibility across multiple cell types. Furthermore, the material exhibits bioadhesive qualities, facilitating stable cell adhesion to its surface. A unique advantage of the formulation is the compatibility with 3D bioprinting, an essential technique for fabricating stable interfaces. A multimaterial sensorized 3D bionic construct is successfully bioprinted, and it is compared to structures produced via hydrogel casting. In contrast to cast constructs, the bioprinted ones display a high (87%) cell viability, preserve differentiation ability, and structural integrity of the sensor–tissue interface throughout the tissue development duration of 10 d. With easy fabrication and effective soft tissue integration, this composite holds significant promise for various biomedical applications, including implantable electronics and organ‐on‐a‐chip technologies.
Bimetallic DNAsome Decorated with G4‐DNA as a Nanozyme for Targeted and Enhanced Chemo/Chemodynamic Cancer Therapy
Authors: Raj Gowtham , Vasantha Anu P. , Sreekumar Vasudev D. , Beena Athul V. , Dommeti Viswa Kalyan Kumar , Perozhy Harsha , Jose Alwin T. , Khurana Satish , Varghese Reji 
Published: April 2024

AbstractCancer is indisputably one of the major threats to mankind, and hence the design of new approaches for the improvement of existing therapeutic strategies is always wanted. Herein, the design of a tumor microenvironment‐responsive, DNA‐based chemodynamic therapy (CDT) nanoagent with dual Fenton reaction centers for targeted cancer therapy is reported. Self‐assembly of DNA amphiphile containing copper complex as the hydrophobic Fenton reaction center results in the formation of CDT‐active DNAsome with Cu2+‐based Fenton catalytic site as the hydrophobic core and hydrophilic ssDNA protrude on the surface. DNA‐based surface addressability of the DNAsome is then used for the integration of second Fenton reaction center, which is a peroxidase‐mimicking DNAzyme noncovalently loaded with Hemin and Doxorubicin, via DNA hybridization to give a CDT agent having dual Fenton reaction centers. Targeted internalization of the CDT nanoagent and selective generation of •OH inside HeLa cell are also shown. Excellent therapeutic efficiency is observed for the CDT nanoagent both in vitro and in vivo, and the enhanced efficacy is attributed to the combined and synergetic action of CDT and chemotherapy.
Formation of 2D Amorphous Lithium Sulfide Enabled by Mo2C Clusters Loaded Carbon Scaffold for High‐Performance Lithium Sulfur Batteries
Authors: Yuan Huadong , Zheng Jianhui , Lu Gongxun , Zhang Liang , Yan Tianran , Luo Jianmin , Wang Yao , Liu Yujing , Guo Tianqi , Wang Zhongchang , Nai Jianwei , Tao Xinyong 
Published: April 2024

AbstractLithium‐sulfur (Li‐S) batteries, operated through the interconversion between sulfur and solid‐state lithium sulfide, are regarded as next‐generation energy storage systems. However, the sluggish kinetics of lithium sulfide deposition/dissolution, caused by its insoluble and insulated nature, hampers the practical use of Li‐S batteries. Herein, leaf‐like carbon scaffold (LCS) with the modification of Mo2C clusters (Mo2C@LCS) is reported as host material of sulfur powder. During cycles, the dissociative Mo ions at the Mo2C@LCS/electrolyte interface are detected to exhibit competitive binding energy with Li ions for lithium sulfide anions, which disrupts the deposition behavior of crystalline lithium sulfide and trends a shift in the configuration of lithium sulfide toward an amorphous structure. Combining the related electrochemical study and first‐principle calculation, it is revealed that the formation of amorphous lithium sulfides shows significantly improved kinetics for lithium sulfide deposition and decomposition. As a result, the obtained Mo2C@LCS/S cathode shows an ultralow capacity decay rate of 0.015% per cycle at a high mass loading of 9.5 mg cm−2 after 700 cycles. More strikingly, an ultrahigh sulfur loading of 61.2 mg cm−2 can also be achieved. This work defines an efficacious strategy to advance the commercialization of Mo2C@LCS host for Li‐S batteries.
3D Printed Microlattices of Transition Metal/Metal Oxides for Highly Stable and Efficient Water Splitting
Authors: Tiwari Anand P. , Rahman Md Saifur , Scheideler William J. 
Published: April 2024

AbstractDeveloping affordable electrocatalysts is crucial for driving the sustainable energy transition to green hydrogen. Here, a generalizable method known as polymer infusion additive manufacturing is reported for transforming 3D‐printed photopolymers into core–shell micro lattice electrodes for electrocatalytic water splitting with transition metal/metal oxides/carbon heterointerfaces. The optimized free‐standing architectures integrate Cu/CuOx on carbon (Cu/CuOx/C) microlattices, yielding high electrocatalytic activity (overpotential of 145 mV at 10 mA cm−2 and a Tafel slope of 134 mV dec−1) and excellent durability for the hydrogen evolution reaction (HER) (>100 h), surpassing state‐of‐the‐art Cu foams. Additionally, for the oxygen evolution reaction (OER), Co/CoOx on carbon (Co/CoOx/C) microlattices display exceptional activity with the lowest overpotential (1.40 V to gain 10 mA cm−2) among all reported PGM‐free electrodes. The study explores the gas phase mass‐transport properties of these 3D microlattices via microscopic imaging of bubble evolution, finding that the outstanding electrocatalytic performance and long‐term stability of microlattice electrodes leverages their mesoscale (100–300 µm) pores, providing accessibility of electrolytes, maximizing utilization of active sites, and ensuring rapid evolution of gas bubbles. Thus, a simple but pioneering method is introduced for manufacturing 3D mesostructured electrocatalysts with deep control of liquid and gas phase mass‐transport, enhancing the efficacy of alkaline water electrolysis.
Wearable Self‐Powered Smart Sensors Enabled by 2D Flower‐Like Ni–Co Layered Double Hydroxides for Copper Monitoring in Sweat
Authors: Zhang Wenrui , Ma Junlin , Zhang Jianxin , Mo Hao , Yang Kai , Zhu Nan 
Published: April 2024

AbstractThe growing power demands of wearable electronic devices have stimulated the development of self‐powered systems in noninvasive healthcare. Herein, ultrathin homogeneous 2D flower‐like nickel–cobalt layered double hydroxide (Ni–Co LDH) nanocomposites are prepared by a one‐step hydrothermal method to integrate a self‐powered system for wearable sweat copper ions (Cu2+) monitoring. The Ni–Co LDH nanocomposites with a lamellar structure and numerous active sites, exhibit sensitive selectivity and low detection limits for Cu2+. In addition, the optimized Ni–Co LDH provides favorable capacitive characteristics as supercapacitors for self‐powering sensors, ensuring continuous sensing energy sources. By connecting wirelessly to a smart device, a self‐powered system is constructed to achieve wearable sensing of Cu2+ in the practical application of sweat. This simple yet effective strategy provides new opportunities for the development of self‐powering health monitoring sensors, as well as smartsensing more heavy metals.
Exploring Memory Function Beyond Immune Cells: ANGPTL4‐Mediated Memory Functions in Tissue Resident Stem Cells
Authors: Park Se‐Ra , Min Eun‐kyung , Kim Soo‐Rim , Kim Suk‐Kyung , Na Kun‐Hee , Park Chan Hum , Jung YunJae , Oh Byung‐Chul , Hong In‐Sun 
Published: April 2024

AbstractAdapted immune cells are known to develop memory functions that increase resistance to subsequent infections after initial pathogen exposure, however, it is unclear whether non‐immune cells, like tissue‐resident stem cells, have similar memory functions. Here, it is found that tissue‐resident stem cells crucial for tissue regeneration show diminished adverse effects on diverse stem cell functions against successive exposure to foreign antigen (β‐glucan) to maintain tissue homeostasis and stability both in vitro and in vivo. These data suggest that endometrial stem cells may possess a robust memory function, in contrast, fully differentiated cells like fibroblasts and vesicular cells do not show these memory mechanisms upon consecutive antigen exposure. Moreover, the pivotal role of Angiopoietin‐like 4 (ANGPTL4) in regulating the memory functions of endometrial stem cells is identified through specific shRNA knockdown in vitro and knockout mice in vivo experiments. ANGPTL4 is associated with the alteration of diverse stem cell functions and epigenetic modifications, notably through histone H3 methylation changes and two pathways (i.e., PI3K/Akt and FAK/ERK1/2 signaling) upon consecutive antigen exposure. These findings imply the existence of inherent self‐defense mechanisms through which local stem cells can adapt and protect themselves from recurrent antigenic challenges, ultimately mitigating adverse consequences.
Novel Personalized Cancer Vaccine Using Tumor Extracellular Vesicles with Attenuated Tumorigenicity and Enhanced Immunogenicity
Authors: Han Jihoon , Kim Seohyun , Hwang Yeong Ha , Kim Seong A , Lee Yeji , Kim Jihong , Cho Seongeon , Woo Jiwan , Jeong Cherlhyun , Kwon Minsu , Nam Gi‐Hoon , Kim In‐San 
Published: April 2024

AbstractCancer vaccines offer a promising avenue in cancer immunotherapy by inducing systemic, tumor‐specific immune responses. Tumor extracellular vesicles (TEVs) are nanoparticles naturally laden with tumor antigens, making them appealing for vaccine development. However, their inherent malignant properties from the original tumor cells limit their direct therapeutic use. This study introduces a novel approach to repurpose TEVs as potent personalized cancer vaccines. The study shows that inhibition of both YAP and autophagy not only diminishes the malignancy‐associated traits of TEVs but also enhances their immunogenic attributes by enriching their load of tumor antigens and adjuvants. These revamped TEVs, termed attenuated yet immunogenically potentiated TEVs (AI‐TEVs), showcase potential in inhibiting tumor growth, both as a preventive measure and a possible treatment for recurrent cancers. They prompt a tumor‐specific and enduring immune memory. In addition, by showing that AI‐TEVs can counteract cancer growth in a personalized vaccine approach, a potential strategy is presented for developing postoperative cancer immunotherapy that's enduring and tailored to individual patients.
Interfacial Electronic Interactions Between Ultrathin NiFe‐MOF Nanosheets and Ir Nanoparticles Heterojunctions Leading to Efficient Overall Water Splitting
Authors: Li Cong , Zhang Wei , Cao Yongyong , Ji Jun‐Yang , Li Zhao‐Chen , Han Xu , Gu Hongwei , Braunstein Pierre , Lang Jian‐Ping 
Published: April 2024

AbstractCreating specific noble metal/metal‐organic framework (MOF) heterojunction nanostructures represents an effective strategy to promote water electrolysis but remains rather challenging. Herein, a heterojunction electrocatalyst is developed by growing Ir nanoparticles on ultrathin NiFe‐MOF nanosheets supported by nickel foam (NF) via a readily accessible solvothermal approach and subsequent redox strategy. Because of the electronic interactions between Ir nanoparticles and NiFe‐MOF nanosheets, the optimized Ir@NiFe‐MOF/NF catalyst exhibits exceptional bifunctional performance for the hydrogen evolution reaction (HER) (η10 = 15 mV, η denotes the overpotential) and oxygen evolution reaction (OER) (η10 = 213 mV) in 1.0 m KOH solution, superior to commercial and recently reported electrocatalysts. Density functional theory calculations are used to further investigate the electronic interactions between Ir nanoparticles and NiFe‐MOF nanosheets, shedding light on the mechanisms behind the enhanced HER and OER performance. This work details a promising approach for the design and development of efficient electrocatalysts for overall water splitting.
GHCU, a Molecular Chaperone, Regulates Leaf Curling by Modulating the Distribution of KNGH1 in Cotton
Authors: Zang Yihao , Xu Chenyu , Yu Lishan , Ma Longen , Xuan Lisha , Yan Sunyi , Zhang Yayao , Cao Yiwen , Li Xiaoran , Si Zhanfeng , Deng Jieqiong , Zhang Tianzhen , Hu Yan 
Published: April 2024

AbstractLeaf shape is considered to be one of the most significant agronomic traits in crop breeding. However, the molecular basis underlying leaf morphogenesis in cotton is still largely unknown. In this study, through genetic mapping and molecular investigation using a natural cotton mutant cu with leaves curling upward, the causal gene GHCU is successfully identified as the key regulator of leaf flattening. Knockout of GHCU or its homolog in cotton and tobacco using CRISPR results in abnormal leaf shape. It is further discovered that GHCU facilitates the transport of the HD protein KNOTTED1‐like (KNGH1) from the adaxial to the abaxial domain. Loss of GHCU function restricts KNGH1 to the adaxial epidermal region, leading to lower auxin response levels in the adaxial boundary compared to the abaxial. This spatial asymmetry in auxin distribution produces the upward‐curled leaf phenotype of the cu mutant. By analysis of single‐cell RNA sequencing and spatiotemporal transcriptomic data, auxin biosynthesis genes are confirmed to be expressed asymmetrically in the adaxial‐abaxial epidermal cells. Overall, these findings suggest that GHCU plays a crucial role in the regulation of leaf flattening through facilitating cell‐to‐cell trafficking of KNGH1 and hence influencing the auxin response level.
Reducing Voltage Losses in Organic Photovoltaics Requires Interfacial Disorder Management
Authors: Wang Rong , Han Leng , Li Ning , Chochos Christos L. , Gregoriou Vasilis G. , Lüer Larry , Brabec Christoph J. 
Published: April 2024

AbstractThanks to the introduction of non‐fullerene acceptors, efficiencies of organic photovoltaics are now approaching 20%. Closing the gap with inorganic photovoltaics requires minimizing voltage losses without penalizing charge extraction, for which microstructure control is crucial. However, the complex interplay between microstructure and charge generation, recombination, and extraction has so far not been unraveled. Here, a systematic study linking device performance to distinct microstructural features via machine learning is presented. Building bi‐layer devices allows to separately study the influence of aggregation and disorder on the energies and lifetimes of bulk and interfacial states. Unambiguous assignments of specific structural motifs to the device photophysics are thus possible. It is found that the control of aggregation‐caused quenching is decisive for the exciton splitting efficiency and thus the carrier generation. Furthermore, the static disorder at the donor–acceptor interface controls the nonradiative recombination by shifting the excited state population from the bulk toward the interface. Finally, the amount of disorder in the bulk is found decisive for charge extraction. The finding that charge generation, recombination, and extraction are controlled by distinct structural features, is the key to optimizing these motifs independently, which will pave the way for organic photovoltaics toward the detailed balance limit.
Unveiling the genetic landscape of suspected congenital dyserythropoietic anemia type I: A retrospective cohort study of 36 patients
Authors: Marra Roberta , Nostroso Antonella , Rosato Barbara Eleni , Esposito Federica Maria , D'Onofrio Vanessa , Iscaro Anthony , Gambale Antonella , Bruschi Barbara , Coccia Paola , Poloni Antonella , Unal Sule , Romano Alberto , Iolascon Achille , Andolfo Immacolata , Russo Roberta 
Published: April 2024

AbstractCongenital Dyserythropoietic Anemia type I (CDA I) is a rare hereditary condition characterized by macrocytic/normocytic anemia, splenomegaly, iron overload, and distinct abnormalities during late erythropoiesis, particularly internuclear bridges between erythroblasts. Diagnosis of CDA I remains challenging due to its rarity, clinical heterogeneity, and overlapping phenotype with other rare hereditary anemias. In this case series, we present 36 patients with suspected CDA I. A molecular diagnosis was successfully established in 89% of cases, identifying 16 patients with CDA I through the presence of 18 causative variants in the CDAN1 or CDIN1 genes. Transcriptomic analysis of CDIN1 variants revealed impaired erythroid differentiation and disruptions in transcription, cell proliferation, and histone regulation. Conversely, 16 individuals received a different diagnosis, primarily pyruvate kinase deficiency. Comparisons between CDA I and non‐CDA I patients revealed no significant differences in erythroblast morphological features. However, hemoglobin levels and red blood cell count differed between the two groups, with non‐CDA I subjects being more severely affected. Notably, most patients with severe anemia belonged to the non‐CDA I group (82% non‐CDA I vs. 18% CDA I), with a subsequent absolute prevalence of transfusion dependency among non‐CDA I patients (100% vs. 41.7%). All patients exhibited reduced bone marrow responsiveness to anemia, with a more pronounced effect observed in non‐CDA I patients. Erythropoietin levels were significantly higher in non‐CDA I patients compared to CDA I patients. However, evaluations of erythroferrone, soluble transferrin receptor, and hepcidin revealed no significant differences in plasma concentration between the two groups.
Highly Condensed and Super‐Incompressible Be2PN3
Authors: Krach Georg , Steinadler Jennifer , Witthaut Kristian , Schnick Wolfgang 
Published: April 2024

AbstractAlthough beryllium and its compounds show outstanding properties, owing to its toxic potential and extreme reaction conditions the chemistry of Be under high‐pressure conditions has only been investigated sparsely. Herein, we report on the highly condensed wurtzite‐type Be2PN3, which was synthesized from Be3N2 and P3N5 in a high‐pressure high‐temperature approach at 9 GPa and 1500 °C. It is the missing member in the row of formula type M2PN3 (M = Mg, Zn). The structure was elucidated by powder X‐ray diffraction (PXRD), revealing that Be2PN3 is a double nitride, rather than a nitridophosphate. The structural model was further corroborated by 9Be and 31P solid‐state nuclear magnetic resonance (NMR) spectroscopy. We present 9Be NMR data for tetrahedral nitride coordination for the first time. Infrared and energy‐dispersive X‐ray spectroscopy (FTIR and EDX), as well as temperature dependent PXRD complement the analytical characterization. Density functional theory (DFT) calculations reveal super‐incompressible behavior and the remarkable hardness of this low‐density material. The formation of Be2PN3 through a high‐pressure high‐temperature approach expands the synthetic access to Be‐containing compounds and may open access to various multinary beryllium nitrides.
Facile Energy Release from Substituted Dewar Isomers of 1,2‐Dihydro‐1,2‐Azaborinines Catalyzed by Coinage Metal Lewis Acids
Authors: Richter Robert C. , Biebl Sonja M. , Einholz Ralf , Walz Johannes , Maichle‐Mössmer Cäcilia , Ströbele Markus , Bettinger Holger F. , Fleischer Ivana 
Published: April 2024

AbstractMolecular solar thermal systems (MOST) represent an auspicious solution for the storage of solar energy. We report silver salts as a unique class of catalysts, capable of releasing the stored energy from the promising 1,2‐dihydro‐1,2‐azaborinine based MOST system. Mechanistic investigations provided insights into the silver catalyzed thermal backreaction, concurrently unveiling the first crystal structure of a 2‐aza‐3‐borabicyclo[2.2.0]hex‐5‐ene, the Dewar isomer of 1,2‐dihydro‐1,2‐azaborinine. Quantification of activation energies by kinetic experiments has elucidated the advantageous energy change associated with Lewis acid catalysts, a phenomenon corroborated through computational analysis. By means of low temperature NMR spectroscopy, mechanistic insights into the coordination of Ag+ to the 1,2‐dihydro‐1,2‐azaborinine were gained.
Dilute RuCo Alloy Synergizing Single Ru and Co Atoms as Efficient and CO‐Resistant Anode Catalyst for Anion Exchange Membrane Fuel Cells
Authors: Cui Zhibo , Ren Zhanghao , Ma Chao , Chen Bowen , Chen Guanzhen , Lu Ruihu , Zhu Wei , Gan Tao , Wang Ziyun , Zhuang Zhongbin , Han Yunhu 
Published: April 2024

AbstractRuthenium (Ru) is considered a promising candidate catalyst for alkaline hydroxide oxidation reaction (HOR) due to its hydrogen binding energy (HBE) like that of platinum (Pt) and its much higher oxygenophilicity than that of Pt. However, Ru still suffers from insufficient intrinsic activity and CO resistance, which hinders its widespread use in anion exchange membrane fuel cells (AEMFCs). Here, we report a hybrid catalyst (RuCo)NC+SAs/N‐CNT consisting of dilute RuCo alloy nanoparticles and atomically single Ru and Co atoms on N‐doped carbon nanotubes The catalyst exhibits a state‐of‐the‐art activity with a high mass activity of 7.35 A mgRu−1. More importantly, when (RuCo)NC+SAs/N‐CNT is used as an anode catalyst for AEMFCs, its peak power density reaches 1.98 W cm−2, which is one of the best AEMFCs properties of noble metal‐based catalysts at present. Moreover, (RuCo)NC+SAs/N‐CNT has superior long‐time stability and CO resistance. The experimental and density functional theory (DFT) results demonstrate that the dilute alloying and monodecentralization of the exotic element Co greatly modulates the electronic structure of the host element Ru, thus optimizing the adsorption of H and OH and promoting the oxidation of CO on the catalyst surface, and then stimulates alkaline HOR activity and CO tolerance of the catalyst.