bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure-based kernels for the prediction of catalytic residues and their involvement in human inherited disease
Authors: Xin Fuxiao , Myers Steven , Li Yong Fuga , Cooper David N. , Mooney Sean D. , Radivojac Predrag 
Published: June 2010

Abstract
Motivation: Enzyme catalysis is involved in numerous biological processes and the disruption of enzymatic activity has been implicated in human disease. Despite this, various aspects of catalytic reactions are not completely understood, such as the mechanics of reaction chemistry and the geometry of catalytic residues within active sites. As a result, the computational prediction of catalytic residues has the potential to identify novel catalytic pockets, aid in the design of more efficient enzymes and also predict the molecular basis of disease.
Results: We propose a new kernel-based algorithm for the prediction of catalytic residues based on protein sequence, structure and evolutionary information. The method relies upon explicit modeling of similarity between residue-centered neighborhoods in protein structures. We present evidence that this algorithm evaluates favorably against established approaches, and also provides insights into the relative importance of the geometry, physicochemical properties and evolutionary conservation of catalytic residue activity. The new algorithm was used to identify known mutations associated with inherited disease whose molecular mechanism might be predicted to operate specifically though the loss or gain of catalytic residues. It should, therefore, provide a viable approach to identifying the molecular basis of disease in which the loss or gain of function is not caused solely by the disruption of protein stability. Our analysis suggests that both mechanisms are actively involved in human inherited disease.
Availability and Implementation: Source code for the structural kernel is available at www.informatics.indiana.edu/predrag/
Contact: predrag@indiana.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Incidental bycatch of short-beaked common dolphins (Delphinus delphis) by pairtrawlers off northwestern Spain
Authors: Fernández-Contreras M. M. , Cardona L. , Lockyer C. H. , Aguilar A. 
Published: June 2010

Abstract
M. M. Fernández-Contreras, L. Cardona, C. H. Lockyer, and A. Aguilar. 2010. Incidental bycatch of short-beaked common dolphins (Delphinus delphis) by pairtrawlers off northwestern Spain. – ICES Journal of Marine Science, 67: 1732–1738. The numbers of short-beaked common dolphins captured annually by pairtrawlers operating off Galicia (northwestern Spain) and the operational factors influencing the bycatch were evaluated using on-board observations. Hauling time, fishing depth, and season of the year were identified as the key factors involved in the incidental capture. The dolphins were most vulnerable to trawls at night from May to September, around the continental shelf break. Most of the dolphins in the bycatch were males, and the average age was 13.4 ± 4.4 years for males and 11.5 ± 4.8 years for females. The sex ratio was male-biased owing to a few capture events involving several males each, supporting the notion that bachelor groups exist in the area. The annual bycatch in 2001 and 2002 was an estimated 394 dolphins [95% confidence interval (CI) 230–632], most taken from May to September (mean 348 dolphins, 95% CI 200–590) and just a few from October to April (mean 46 dolphins, 95% CI 0–132). This level of bycatch could be reduced significantly if trawlers were restricted to operating in water deeper than 250 m and likely avoided entirely if they were restricted to water deeper than 300 m.
A pilot study of the Histone‐Deacetylase inhibitor Givinostat in patients with JAK2V617F positive chronic myeloproliferative neoplasms
Authors: Rambaldi Alessandro , Dellacasa Chiara Maria , Finazzi Guido , Carobbio Alessandra , Ferrari Maria Luisa , Guglielmelli Paola , Gattoni Elisabetta , Salmoiraghi Silvia , Finazzi Maria Chiara , Di Tollo Silvia , D’Urzo Carmine , Vannucchi Alessandro M. , Barosi Giovanni , Barbui Tiziano 
Published: June 2010

SummaryA phase II A study was conducted to evaluate the safety and efficacy of Givinostat, a novel Histone‐Deacetylases inhibitor, in patients with Polycythaemia Vera (PV, n = 12), Essential Thrombocythaemia (ET, n = 1) and Myelofibrosis (n = 16), bearing the JAK2V617F mutation. The study was approved by the local ethics committees and all human participants gave written informed consent. Givinostat was given orally for 24 weeks at a starting dose of 50 mg twice daily. The median treatment duration was 20 weeks. Reasons for treatment discontinuation were disease progression (n = 6), grade 2 thrombocytopenia (n = 1), psychiatric symptoms (n = 1) and withdrawn consent (n = 2). A dose reduction was applied in 10 patients while a temporary interruption occurred in 15. Among 13 PV/ET patients, 1 complete, 6 partial and 4 no responses were documented at study end while 2 patients went off‐study, prematurely. Three major responses were registered among 16 MF patients. Pruritus disappeared in most patients and reduction of splenomegaly was observed in 75% of PV/ET and 38% of MF patients. Reverse transcription polymerase chain reaction identified a trend to reduction of the JAK2V617F allele burden. Givinostat was well tolerated and could induce haematological response in most PV and some MF patients.
Phenotypic plasticity of thermal tolerance contributes to the invasion potential of Mediterranean fruit flies (Ceratitis capitata)
Authors: NYAMUKONDIWA CASPER , KLEYNHANS ELSJE , TERBLANCHE JOHN S. 
Published: June 2010

1. The invasion success of Ceratitis capitata probably stems from physiological, morphological, and behavioural adaptations that enable them to survive in different habitats. However, it is generally poorly understood if variation in acute thermal tolerance and its phenotypic plasticity might be important in facilitating survival of C. capitata upon introduction to novel environments.2. Here, by comparison of widely distributed C. capitata with a narrowly distributed congener, C. rosa, we show that both species have similar levels of survival to acute high and low temperature exposures under common rearing conditions. However, these species differ dramatically in the time‐course of plastic responses to acute low temperature treatments.3. The range of temperatures that induce rapid cold hardening (RCH) are similar for both species. However, C. capitata has two distinct advantages over C. rosa. First, at 5°C C. capitata develops RCH significantly faster than C. rosa. Second, C. capitata maintains a RCH response longer than C. rosa (8 vs. 0.5 h).4. A simple population survival model, based on the estimated time‐course of RCH responses determined for both species, was undertaken to simulate time to extinction for both species introduced into a similar thermally variable environment. The model showed that time to extinction is greater for C. capitata than for C. rosa, especially in habitats where temperatures frequently drop below 10°C.5. Thus, variation in RCH responses may translate into significant variation in survival upon introduction to novel thermal habitats for C. capitata, particularly in cooler and more thermally variable geographic regions, and may contribute to their ongoing invasion success relative to other, more geographically constrained Ceratitis species.
Parents, spouses, and children of hospitalized patients: evaluation of nursing care
Authors: Yagil Dana , Luria Gil , Admi Hanna , Moshe‐Eilon Yael , Linn Shai 
Published: June 2010

yagil d., luria g., admi h., moshe‐eilon y. & linn s. (2010) Parents, spouses, and children of hospitalized patients: evaluation of nursing care. Journal of Advanced Nursing 66(8), 1793–1801.AbstractTitle.  Parents, spouses, and children of hospitalized patients: evaluation of nursing care. Aim.  This paper is a report of a study of the effect of kinship type and gender on family members’ evaluation of nursing care for patients and their families in hospital units.Background.  With increasing competition in the healthcare system, hospitals attribute great importance to client satisfaction, which is strongly related to the quality of nursing care. However, to date there has been little research into family members’ evaluation of nursing care.Methods.  Questionnaires were administered to spouses, parents and children (n = 441) of hospitalized patients in three Israeli hospitals during 2007–2008.Results.  Kinship type interacted with gender in affecting family members’ evaluation of the quality of nursing care. Among men, husbands were the most satisfied with nursing behaviour, treatment of the patients, and the information they receive. Fathers were the least satisfied. Overall family evaluation of the service was predicted by their evaluation of caring, treatment, and the patient’s environment; departmental reputation was predicted by evaluation of treatment.Conclusion.  Nurses should be trained to develop sensitivity to the diverse expectations and needs of relatives, as well as awareness of how their own preconceptions affect their behaviour toward patients’ families. Nurses should develop self‐awareness of possible stereotypes and prejudices that may bias their behaviour towards family members. Reactions of family members should also be included in surveys of client satisfaction with nursing care.
Health‐related quality of life in patients undergoing peritoneal dialysis: effects of a nurse‐led case management programme
Authors: Chow Susan Ka Yee , Wong Frances K.Y. 
Published: June 2010

chow s.k.y. & wong f.k.y. (2010) Health‐related quality of life in patients undergoing peritoneal dialysis: effects of a nurse‐led case management programme. Journal of Advanced Nursing 66(8), 1780–1792.AbstractTitle.  Health‐related quality of life in patients undergoing peritoneal dialysis: effects of a nurse‐led case management programme. Aim.  This paper is a report of an examination of the effectiveness of a nurse‐led case management programme in improving the quality of life of peritoneal dialysis patients in Hong Kong.Background.  Patients with end‐stage renal failure need integrated health care to maintain a desirable quality of life. Studies suggest that transitional care using a nurse case management model has a positive effect for patients suffering from chronic diseases, but the results have not been conclusive.Method.  Eighty‐five patients participated in the study in 2005, 43 in the study group and 42 in the control group. Patients in the control group received routine hospital discharge services. Study group patients received a comprehensive education programme prior to discharge and standardized, 6‐week nurse‐initiated telephone follow‐up. Kidney disease quality of life was measured for each patient at three time intervals: before the intervention, at completion of the 6‐week intervention and 6 weeks after completion of the programme.Results.  Repeated measures analysis of variance, general linear model was carried out. Statistically significant within‐group effects were found for symptoms/problems, effects of kidney disease, sleep, role‐physical, pain, emotional wellbeing and social function. Statistically significant interaction effects were demonstrated for staff encouragement, patient satisfaction, sleep and social function.Conclusion.  The nurse‐led case management programme can be applied effectively to patients receiving peritoneal dialysis. The new model of care is particularly useful for enhancing patients’ wellbeing in the transition from hospital to home.
How adolescent patients use ward space
Authors: Hutton Alison 
Published: June 2010

hutton a. (2010) How adolescent patients use ward space. Journal of Advanced Nursing 66(8), 1802–1809.AbstractTitle.  How adolescent patients use ward space. Aim.  This paper is a report of a study of the use of ward space in a purpose‐built adolescent ward and the influence of that space on both adolescent patients and nurses.Background.  A separate ward environment gives adolescent patients opportunities to be with peers, have privacy and independence and be nursed away from younger children. The aim of adolescent wards is to cater for these differences and to set routines around this age group.Methods.  Data were collected between 2002 and 2003 by participant observation and interview. In total 35 observations were undertaken of both adolescents and nursing staff, with associated interviews. A further 17 semi‐structured individual nurse and 11 adolescent interviews were conducted, aimed at exploring the use of ward space. Patient demographics, ward policies and patient information sheets were also used.Findings.  Adolescent patients created their own spaces on the ward from personal effects that were of interest to them. These spaces show nurses who they are. Adolescent patients want to be identified as more than ‘just’ a patient when they are in hospital. What the creation of these spaces does is assist the adolescent patient in escaping the homogeneity of the ward by cutting across its activities.Conclusions.  By understanding patients through their self‐created spaces, nurses can improve the capacity of adolescents to contribute to their own care, whilst enhancing their care experiences through understanding and collaboration.
Recovery after coronary artery bypass surgery: effect of an audiotape information programme
Authors: Utriyaprasit Ketsarin , Moore Shirley M. , Chaiseri Praditchai 
Published: June 2010

utriyaprasit k., moore s.m. & chaiseri p. (2010) Recovery after coronary artery bypass surgery: effect of an audiotape information programme. Journal of Advanced Nursing 66(8), 1747–1759.AbstractTitle.  Recovery after coronary artery bypass surgery: effect of an audiotape information programme. Aim.  The aim of the study was to test the effect of an audiotape giving concrete objective information and strategies to reduce symptoms, psychological distress and enhance physical functioning in patients having coronary artery bypass grafts.Background.  The period following hospital discharge is stressful for patients having coronary artery bypass grafts. Evident‐based interventions are needed to improve outcomes in Thai populations following coronary artery bypass graft surgery.Methods.  A randomized controlled trial was conducted during 2004–2005. A sample of 120 Thai patients having coronary artery bypass grafts was randomly assigned to an intervention group or a control group. The intervention group was given an information audiotape the day prior to hospital discharge, and encouraged to listen to it as many times as necessary. Participants were interviewed using validated instruments predischarge and at 2 weeks and 4 weeks after discharge.Findings.  Participants in the intervention group had statistically significantly fewer symptoms of shoulder, back or neck pain and lack of appetite, and increased physical activity after discharge, compared to the control group. This effect remained statistically significant after controlling for age, gender, co‐morbidity and presurgical cardiac functional status. However, no statistically significant difference in psychological distress was observed.Conclusion.  Nurses can use an audiotape containing preparatory information to improve outcomes for patients having coronary artery bypass grafts during the few weeks after discharge from hospital. Further studies are recommended to improve its effect on psychological distress.
Nursing work environment and nurse caring: relationship among motivational factors
Authors: Burtson Paige L. , Stichler Jaynelle F. 
Published: June 2010

burtson p.l. & stichler j.f. (2010) Nursing work environment and nurse caring: relationship among motivational factors. Journal of Advanced Nursing 66(8), 1819–1831.AbstractTitle.  Nursing work environment and nurse caring: relationship among motivational factors. Aim.  This paper is a report of a study of the relationships among compassion satisfaction, nurse job satisfaction, stress, burnout and compassion fatigue to nurse caring.Background.  Nurse caring is the most influential dimension of patient advocation and is predictive of patient satisfaction. Qualitative studies have indicated that nurse caring is a key motivational factor impacting recruitment and retention.Methods.  A correlational study of nurses (N = 126) was conducted in 2008 at a single, academic medical center. The six variables of interest were operationalized using four valid and reliable research instruments: (1) the Mueller McCloskey Satisfaction Scale, (2) the Professional Quality of Life Scale, (3) the Stress in General Scale and (4) the Caring Behaviors Inventory.Results.  Pearson Product–moment correlations showed statistically significant relationships between nurse caring and compassion satisfaction (r = 0·51, P < 0·001), nurse job satisfaction subscales (r = 0·16–0·28, P < 0·05), stress (r = −0·21, P < 0·05), and burnout (r = −0·22, P < 0·01). A statistically significant relationship was found between the nurse caring subscale of knowledge and skill and compassion fatigue (r = −0·22, P < 0·01). Hierarchical multiple regression analysis demonstrated that compassion satisfaction (R2 = 0·287, β = 0·536, P = 0·000) and nurse satisfaction with social interaction opportunities related to work (β = 0·223, P = 0·032) explained variability in nurse caring.Conclusion.  Fostering compassion satisfaction and social interaction opportunities among nurses may improve nurse caring, potentially sustaining long‐term improvements in patient.
Factors influencing heart failure patients’ sleep quality
Authors: Wang Tsae‐Jyy , Lee Shu‐Chiung , Tsay Shiow‐Luan , Tung Heng‐Hsin 
Published: June 2010

wang t.‐j., lee s.‐c., tsay s.‐l. & tung h.‐h. (2010) Factors influencing heart failure patients’ sleep quality. Journal of Advanced Nursing 66(8), 1730–1740.AbstractTitle.  Factors influencing heart failure patients’ sleep quality. Aim.  The aim of the study was to describe the factors influencing the sleep quality of patients with heart failure.Background.  Sleep problems are common in patients with heart failure, and have a negative impact on their quality of life. Patients with heart failure often have difficulties in lying supine to sleep, falling asleep, and maintaining sleep, as well as waking up too early.Methods.  A predictive correlational design was used, with 101 patients with heart failure recruited from cardiology clinics in Taiwan. Patients completed questionnaires, and data were collected in 2007. Statistical analyses included descriptive statistics, t‐tests, analysis of variance, Pearson product moment correlation coefficients, and multiple regression.Results.  The mean score for sleep quality was 10·78 (sd = 4·78), as measured by the Pittsburgh Sleep Quality Index. Overall, 81% of participants reported poor sleep quality, and 31% were unsatisfied with the quality of their sleep. Sleep efficacy and hours of sleep during the night were rated as the lowest among the dimensions of sleep quality. The most common reason for interruption of sleep was getting up to urinate at night. Stepwise multiple regression analysis showed that the factors related to sleep quality were gender, perceived health, depressive mood, and the number of comorbidities. These four variables explained 31% of the variance in the sleep quality of these patients.Conclusion.  Patients with heart failure should be taught sleep hygiene and to increase leisure time activities, disease self‐management, and emotional adjustment skills to improve their sleep quality. These patients should also be observed for night time safety risk due to nocturia.
Inpatient falls in adult acute care settings: influence of patients’ mental status
Authors: Tzeng Huey‐Ming 
Published: June 2010

tzeng h.‐m. (2010) Inpatient falls in adult acute care settings: influence of patients’ mental status. Journal of Advanced Nursing 66(8), 1741–1746.AbstractTitle.  Inpatient falls in adult acute care settings: influence of patients’ mental status. Aim.  This paper is a report of a study of fallers’ mental status as one of the patient‐related intrinsic risk factors for falls.Background.  Whether confusion is one of the most important risk factors associated with risk of falling in hospital settings is unclear. Literature reviews have not identified consistent evidence for effective preventive interventions for patients with mental status deficits.Methods.  This retrospective research was conducted in six adult acute care units in a community hospital in the United States of America. The data source was the 1017 fall incidents occurring between 1 July 2005 and 30 April 2009. Descriptive statistics and Pearson chi‐square tests were used to analyse the data.Results.  The presence of mental status deficits was identified as the dominant issue in 346 (34%) falls. The group of fallers with mental status deficits (32·1%, n = 111) seemed to have fewer toileting‐related falls than those without mental status deficits (46·7%, n = 314). Fallers with mental status deficits tended to have more severe fall injuries than those without mental status deficits (χ2 = 10·08, d.f. = 3, P = 0·018).Conclusion.  Risk assessment and targeted surveillance should be used as part of falls prevention policy. Involving nursing staff and family members in assessing a patient’s mental status may help to prevent falls caused by mental status deficits.
Quality nursing care in the words of nurses
Authors: Burhans Linda Maas , Alligood Martha Raile 
Published: June 2010

burhans l.m. & alligood m.r. (2010) Quality nursing care in the words of nurses. Journal of Advanced Nursing 66(8), 1689–1697.AbstractTitle.  Quality nursing care in the words of nurses. Aim.  This paper is a report of a study of the meaning of quality nursing care for practising nurses.Background.  Healthcare quality continues to be a subject of intense criticism and debate. Although quality nursing care is vital to patient outcomes and safety, meaningful improvements have been disturbingly slow. Analysis of quality care literature reveals that practising nurses are rarely involved in developing or defining improvement programs for quality nursing care. Therefore, two major study premises were that quality nursing care must be meaningful and relevant to nurses and that uncovering their meaning of quality nursing care could facilitate more effective improvement approaches.Method.  Using van Manen’s hermeneutic phenomenology, meaning was revealed through analysis of interviews to answer the research question ‘What is the lived meaning of quality nursing care for practising nurses?’ Twelve nurses practising on medical or surgical adult units at general or intermediate levels of care within acute care hospitals in the United States of America were interviewed. Emerging themes were discovered through empirical and reflective analysis of audiotapes and transcripts. The data were collected in 2008.Findings.  The revealed lived meaning of quality nursing care for practising nurses was meeting human needs through caring, empathetic, respectful interactions within which responsibility, intentionality and advocacy form an essential, integral foundation.Conclusion.  Nurse managers could develop strategies that support nurses better in identifying and delivering quality nursing care reflective of responsibility, caring, intentionality, empathy, respect and advocacy. Nurse educators could modify education curricula to model and teach students the intrinsic qualities identified within these meanings of quality nursing care.