bluuebunny/crossref_metadata_2025_split huggingface dataset:
The State of the Art in Visual Analytics for 3D Urban Data
Authors: Miranda Fabio , Ortner Thomas , Moreira Gustavo , Hosseini Maryam , Vuckovic Milena , Biljecki Filip , Silva Claudio T. , Lage Marcos , Ferreira Nivan 
Published: June 2024

AbstractUrbanization has amplified the importance of three‐dimensional structures in urban environments for a wide range of phenomena that are of significant interest to diverse stakeholders. With the growing availability of 3D urban data, numerous studies have focused on developing visual analysis techniques tailored to the unique characteristics of urban environments. However, incorporating the third dimension into visual analytics introduces additional challenges in designing effective visual tools to tackle urban data's diverse complexities. In this paper, we present a survey on visual analytics of 3D urban data. Our work characterizes published works along three main dimensions (why, what, andhow), considering use cases, analysis tasks, data, visualizations, and interactions. We provide a fine‐grained categorization of published works from visualization journals and conferences, as well as from a myriad of urban domains, including urban planning, architecture, and engineering. By incorporating perspectives from both urban and visualization experts, we identify literature gaps, motivate visualization researchers to understand challenges and opportunities, and indicate future research directions.
Alveolar ridge preservation versus early implant placement in single non‐molar sites: A systematic review and meta‐analysis
Authors: Atieh Momen A. , Shah Maanas , Hakam Abeer , AlAli Fawaghi , Aboushakra Ibrahim , Alsabeeha Nabeel H. M. 
Published: June 2024

AbstractObjectivesThe aim of this systematic review and meta‐analyses was to evaluate the outcomes of alveolar ridge preservation (ARP) following extraction of non‐molar teeth in comparison to early implant placement (EIP) in terms of clinical and radiographic changes, need for additional augmentation at the time of implant placement, patient‐reported outcomes, and implant failure rate.MethodsElectronic databases were searched to identify randomized and non‐randomized studies that compared ARP to EIP. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool. Data were analyzed using a statistical software program.ResultsA total of 106 studies were identified, of which five studies with 198 non‐molar extraction sockets in 198 participants were included. Overall meta‐analysis showed significant differences in changes in midfacial mucosal margin (mean difference (MD) −0.09; 95% confidence interval (CI) −0.17 to −0.01; p = .03) and ridge width (MD −1.70; 95% CI −3.19 to −0.20; p = .03) in favor of ARP. The use of ARP was also associated with less need for additional augmentation at implant placement, but the difference was not statistically significant.ConclusionsWithin the limitation of this review, ARP following extraction of non‐molar teeth has short‐term positive effects on soft tissue contour, mucosal margin and thickness, and alveolar ridge width and height. It can also simplify future implant treatment by minimizing the need for additional augmentation.
Implications of pretreatment extramural venous invasion in rectal cancer patients: A population‐based study
Authors: Rutegård Martin , Matthiessen Peter , Glimelius Bengt , Blomqvist Lennart 
Published: June 2024

AbstractAimExtramural venous invasion detected by MRI (mrEMVI) has in several expert centre studies been identified as an important prognostic factor in rectal cancer, and in guiding neoadjuvant therapy. However, population‐based evidence for mrEMVI as a predictor for recurrent disease is lacking.MethodThis was a multicentre retrospective study based on the Swedish Colorectal Cancer Registry. The study period encompassed patients operated with abdominal resection for rectal cancer 2017–2021, with follow‐up until January 2023. Patients diagnosed at hospitals with radiological registry data coverage <90% or with metastatic disease were excluded. Pretreatment mrEMVI constituted exposure, while recurrence‐free survival was the main outcome. Distant and local recurrence, and overall survival were secondary outcomes, and pretreatment and postoperative scenarios were explored using multivariable Cox regression with multiple imputation. Hazard ratios (HRs) with 95% confidence intervals (CIs) were reported.ResultsA total of 2737 patients from 13 hospitals were eligible for analysis. Pretreatment mrEMVI was reported in 14.5% of patients, while 71.9% had negative findings and 13.6% had missing data. In the pretreatment scenario, mrEMVI was an independent predictor for worse recurrence‐free survival with an adjusted HR of 1.64 (95% CI: 1.31–2.06). In the postoperative MDT setting, the influence of mrEMVI on recurrence‐free survival decreased with an adjusted HR of 1.27 (95% CI: 1.00–1.61).ConclusionmrEMVI at diagnosis is an independent predictor of recurrence‐free survival in an unselected population of rectal cancer patients undergoing abdominal resection.
Wavelet analysis of the foreign aid and economic growth nexus in Turkey
Authors: Adebayo Tomiwa S. , Kalmaz Demet B. , Awosusi Abraham A. 
Published: June 2024

AbstractTurkey is one of the highest donors in the world, who also receives substantial amount of aids from various entities and countries. This paper aims to investigate the on going nexus between economic growth (EG) and foreign aid (AID) in Turkey; utilizing yearly data between 1960 and 2022 by employing wavelet analysis tools: namely the power spectrum, wavelet coherence, wavelet cohesion and Continuous Wavelet Transform (CWT) causality approach, which provides information of both long‐run and short‐run linkages for separate subperiods of time and frequencies. Our results reveal that; (a) the result of the power spectrum indicates that at different frequency and period, there is evidence of significant variation in EG and AID; (b) the outcome of the wavelet coherence confirms that there is comovement at varying frequencies and varying periods between EG and AID, with AID leading; (c) the outcome of the wavelet cohesion shows a positive/negative connection in the short and medium term, but a negative connection in the long term; (d) the result of the CWT causality approach confirmed the ‘feedback hypothesis’ at the aggregate level, in‐phase and out‐phase condition. As a result, policymakers should be more effective in supporting EG at high frequencies and only under the rule of the economic cycle.
Human‐modified habitats imperil ornamented dragonflies less than their non‐ornamented counterparts at local, regional, and continental scales
Authors: Moore Michael P. , Leith Noah T. , Fowler‐Finn Kasey D. , Medley Kim A. 
Published: June 2024

AbstractBiologists have long wondered how sexual ornamentation influences a species' risk of extinction. Because the evolution of condition‐dependent ornamentation can reduce intersexual conflict and accelerate the fixation of advantageous alleles, some theory predicts that ornamented taxa can be buffered against extinction in novel and/or stressful environments. Nevertheless, evidence from the wild remains limited. Here, we show that ornamented dragonflies are less vulnerable to extinction across multiple spatial scales. Population‐occupancy models across the Western United States reveal that ornamented species have become more common relative to non‐ornamented species over >100 years. Phylogenetic analyses indicate that ornamented species exhibit lower continent‐wide extinction risk than non‐ornamented species. Finally, spatial analyses of local dragonfly assemblages suggest that ornamented species possess advantages over non‐ornamented taxa at living in habitats that have been converted to farms and cities. Together, these findings suggest that ornamented taxa are buffered against contemporary extinction at local, regional, and continental scales.
Cognitive deficits and cortical volume loss in COVID‐19‐related hyposmia
Authors: Gezegen Haşim , Ay Ulaş , Samancı Bedia , Kurt Elif , Yörük Sanem Sultan , Medetalibeyoğlu Alpay , Şen Cömert , Şahin Erdi , Barbüroğlu Mehmet , Doğan Faruk Uğur , Bilgiç Başar , Hanağası Haşmet , Gürvit Hakan 
Published: June 2024

AbstractBackground and purposeStudies have found that up to 73% of COVID‐19 patients experience hyposmia. It is unclear if the loss of smell in COVID‐19 is due to damage to the peripheral or central mechanisms. This study aimed to explore the impacts of COVID‐19‐induced hyposmia on brain structure and cognitive functions.MethodsThe study included 36 hyposmic (h‐COV) and 21 normosmic (n‐COV) participants who had recovered from mild COVID‐19 infection, as well as 25 healthy controls (HCs). All participants underwent neurological examination, neuropsychiatric assessment and Sniffin’ Sticks tests. High‐resolution anatomical images were collected; olfactory bulb (OB) volume and cortical thickness were measured.ResultsAddenbrooke's Cognitive Examination—Revised total and language sub‐scores were slightly but significantly lower in the h‐COV group compared to the HC group (p = 0.04 and p = 0.037). The h‐COV group exhibited poorer performance in the Sniffin’ Sticks test terms of discrimination score, identification score and the composite score compared to the n‐COV and HC groups (p < 0.001, p = 0.001 and p = 0.002 respectively). A decrease in left and right OB volumes was observed in the h‐COV group compared to the n‐COV and HC groups (p = 0.003 and p = 0.006 respectively). The cortical thickness analysis revealed atrophy in the left lateral orbitofrontal cortex in the h‐COV group compared to HCs. A significant low positive correlation of varying degrees was detected between discrimination and identification scores and both OB and left orbital sulci.ConclusionTemporary or permanent hyposmia after COVID‐19 infection leads to atrophy in the OB and olfactory‐related cortical structures and subtle cognitive problems in the long term.
The Representativeness of Subslab Soil Gas Collection as Effected by Probe Construction and Sampling Methods
Authors: Zimmerman John H. , Williams Alan , Schumacher Brian , Lutes Chris , Levy Laurent , Buckley Gwen , Boyd Victoria , Holton Chase , McAlary Todd , Truesdale Robert 
Published: June 2024

AbstractSubslab soil gas (SSSG) samples were collected as part of an investigation to evaluate vapor intrusion (VI) into a building. The June 2015 Office of Solid Waste and Emergency Response (OSWER) VI Guide (U.S. Environmental Protection Agency [U.S. EPA] 2015) does not provide specific, detailed recommendations regarding how to collect SSSG samples. The data collected in this study will be used to provide input into future OSWER VI Guidance documents on SSSG sample collection. To this end, three different types of subslab sampling ports were constructed with various sampling techniques within a hexagon‐shaped grid in near proximity to each other. Conventional‐, Vapor Pin‐, and California‐style ports were established in duplicate for continual analysis by onsite gas chromatography‐electron capture detection (GC‐ECD). Triplicate ports were established to evaluate active and passive long‐term sampling methods to determine short range temporal differences. Active sampling methods included evacuated stainless‐steel canisters fitted with capillary flow controllers (Modified U.S. EPA Method TO‐15 [U.S. EPA 1999a]) and sorbent tubes collected using a syringe (Modified EPA TO‐17 [U.S. EPA 1999b]). The Passive sampling method used was sorbent tube samples collected following the EPA TO‐17 sampling method (Modified). This study did not identify any systematic differences in sample results between conventional, Vapor Pin, and CA‐style probes for used in SSSG sampling. The decisions for site management would probably be the same for data from any subslab port style, active or passive sampling techniques over durations less than 2 weeks.
Fourteen‐Day Tegoprazan–Amoxicillin Dual Therapy as the First‐Line Treatment of Helicobacter pylori Infection (SHARE2301): A Multicenter, Noninferiority, Randomized Clinical Trial
Authors: Kong Qingzhou , Mirza Iqtida Ahmed , Zhang Xiaoqian , Song Xiaohui , Li Xiaowei , Zhang Qiumei , Xu Lidong , Guo Yuting , Yu Yanan , Zuo Xiuli , Li Yanqing , Li Yueyue 
Published: June 2024

ABSTRACTBackgroundPotassium‐competitive acid blockers have demonstrated enormous potential in the eradication treatment of Helicobacter pylori infection, with tegoprazan being one of the representatives. The available data on the safety and efficacy of tegoprazan in dual therapy are limited.Materials and MethodsThe multicenter, noninferiority, randomized‐controlled trial was conducted from May 2023 to March 2024. Treatment‐naive subjects were randomly assigned (1:1) to enter either the tegoprazan–amoxicillin (TA) group (tegoprazan 50 mg twice daily and amoxicillin 750 mg four times daily) or the esomeprazole–amoxicillin (EA) group (esomeprazole 20 mg and amoxicillin 750 mg all four times daily), with a duration for 14 days. The primary outcome was eradication rate as determined by 13C‐urea breath test, including per‐protocol (PP) analysis and intention‐to‐treat (ITT) analysis. Secondary outcomes were adverse events and compliance.ResultsA total of 368 individuals were included in the randomization. The eradication rates in the EA group and the TA group were 84.2% and 85.8%, respectively, according to an ITT analysis (p = 0.77), and 88.5% and 88.2%, respectively, according to PP analysis (p = 1.00). The eradication rates for the TA group were not inferior to those of the EA group in both PP (p = 0.0023) and ITT analyses (p = 0.0009). There were no significant statistical differences in the incidence of adverse events and compliance between the two groups. The multivariate logistic regression analysis revealed that poor compliance increased the risk of eradication failure (p < 0.001).ConclusionsDual therapy containing tegoprazan is safe and effective to be considered as a clinical first‐line treatment option, but further optimization involving antimicrobial susceptibility testing and adjustments in dosage and frequency is warranted.Trial RegistrationClinicalTrials.gov ID: NCT05870683.
Novel mutation of transferrin receptor 2 causing hereditary hemochromatosis type 3 in a Japanese patient
Authors: Tamai Yasuyuki , Hosotani Masami , Shigefuku Ryuta , Tsuboi Junya , Iwasa Motoh , Okugawa Yoshinaga , Nakagawa Hayato 
Published: June 2024

AbstractHereditary hemochromatosis (HH) is recognized as a progressive iron‐storage disorder, and leading to severe organ impairments, including liver cirrhosis. Hereditary hemochromatosis type 3 arises from mutations in the transferrin receptor 2 (TFR2) gene. However, HH type 3 is rare in Asia, and information regarding genetic mutations and associated phenotypes remains limited. Here, we reported the case of a Japanese patient with HH type 3, with a novel homozygous mutation of the TFR2 gene. A 69‐year‐old woman presented to our hospital with hand joint pain and was referred due to liver impairment. Viral hepatitis and autoimmune liver diseases were ruled out. However, the transferrin saturation was 92.2%, and the serum ferritin level was 1611.8 ng/mL. Additionally, abdominal computed tomography showed diffuse increased density of the liver parenchyma. Abdominal magnetic resonance imaging also suggested iron deposition. There is no history of prior treatments involving blood transfusions or iron agents. Her parents were involved in a consanguineous marriage, prompting genetic testing. She had a homozygous novel mutation, c.1337G>A (p.G446E), in the TFR2 gene. Serum hepcidin‐25 level was decreased to 2.9 ng/mL. According to the American Society of Medical Genetics and Genomics guideline, the mutation was classified as likely pathogenic, leading to the diagnosis of HH type 3. Following phlebotomy, her arthritis resolved, and serum transaminase levels were normalized. This case marks the first demonstration of homozygous mutation, c.1337G>A (p.G446E), in the TFR2 gene in patients with HH type 3.
Amorphization‐controlled ion release of cobalt‐exchanged zeolite X
Authors: Azar Ayda Nemati Vesali , Duval Alexis , Langenhorst Falko , Wondraczek Lothar 
Published: June 2024

AbstractZeolitic carrier materials offer ion release and uptake functionality for a wide range of applications. The release kinetics are controlled by the mobility of the target species within the zeolite framework and at its surface. Here, we achieve control over the release dynamics and the quantity of released Co2+ ions from a faujasitic zeolite through mechanical amorphization of the zeolite framework. We identify a two‐step reaction mechanism in which ion release and reintegration compete on short and intermediate timescales. The competition between these two processes is governed by the degree of amorphization, with a timescale ranging from a few minutes to several days.
Akokisa River Pedagogies
Authors: Kalin Nadine M. 
Published: June 2024

AbstractThe loss of relational networks and life‐sustaining capacities of the Earth resulting from the Anthropocene/Capitalocene provoke ambiguous pedagogical experimenting with the limits of the known. The Akokisa River of Texas is more than its extractive use‐value based on humanist rationality. Water connector Ángel Faz approaches the River as more than a passive and endless resource to be extracted and manoeuvred for profit, but as an ecology of relations entangled with humans—the River is us; we are the River. As a boundary agitator, Faz speculates into unresolvable and reciprocal voids located in the excluded middles between humans and more‐than‐humans ripe with potential percepts and affects across River multiplicities. Such gesturing generates transcorporeal, multi‐linguistic, uncanny, trickster, and shimmering pedagogies bewildering the capacity to participate in the dynamic indeterminacy and interconnectedness of the River's ongoing becoming.
Development and usability of an EHR‐driven hypertension disparities dashboard in primary care: A qualitative study
Authors: Adediran Emmanuel , Owens Robert , Gardner Elena , Lockrey Alex , Carlson Emily , Forbes Danielle , Stuligross John , Ose Dominik 
Published: June 2024

AbstractHypertension disparities persist and remain high among racial and ethnic minority populations in the United States (US). Data‐driven approaches based on electronic health records (EHRs) in primary care are seen as a strong opportunity to address this situation. This qualitative study evaluated the development, sustainability, and usability of an EHR‐integrated hypertension disparities dashboard for health care professionals in primary care. Ten semi‐structured interviews, exploring the approach and sustainability, as well as eight usability interviews, using the think aloud protocol were conducted with quality improvement managers, data analysts, program managers, evaluators, and primary care providers. For the results, dashboard development steps include having clear goals, defining a target audience, compiling data, and building multidisciplinary teams. For sustainability, the dashboard can enhance understanding of the social determinants of health or to inform QI projects. In terms of dashboard usability, positive aspects consisted of the inclusion of summary pages, patient's detail pages, and hover‐over interface. Important design considerations were refining sorting functions, gender inclusivity, and increasing dashboard visibility. In sum, an EHR‐driven dashboard can be a novel tool for addressing hypertension disparities in primary care. It offers a platform where clinicians can identify patients for culturally tailored interventions. Factors such as physician time constraints, data definitions, comprehensive patient demographic information, end‐users, and future sustenance, should be considered before implementing a dashboard. Additional research is needed to identify practices for integrating a dashboard into clinical workflow for hypertension.
Attractant spray enhances nesting preference and reduces macroparasite infestation of Osmia cornuta
Authors: Eeraerts Maxime 
Published: June 2024

AbstractMason bees (Osmia. spp) can provide an alternative for crop pollination management in addition to the Western honeybees (Apis mellifera). Targeted evidence‐based guidelines can improve cost‐effective management of mason bees. Here, I test the effect of an attractant spray developed in the United States for improving the nesting preference for artificial trap nests of mason bees in Belgium. More specifically, this study investigates the effect of the attractant spray on the nesting preference and nesting performance of the European orchard bee (Osmia cornuta), as well as its effect on the infestation of nest‐associated macroparasites. The number of sealed nesting cavities was twice as high in the trap nests that were treated with the attractant spray. Nesting performance expressed as number of brood cells per cavity, successful cocoon formation, adult emergence, proportion of female bees in the offspring and the number of dead larvae was not different between the treated and the untreated nests. Overall infestation of macroparasites, and infestation of drosophilid flies in particular, were both twice as high in untreated nests. This study provides evidence that the attractant spray improves nesting preference and reduces macroparasite infestation in O. cornuta. The use of this attractant can provide growers and stakeholders with an effective management strategy to prevent infestation by macroparasites and promote efficient bee breeding.
Photobiomodulation in the infrared spectrum reverses the expansion of circulating natural killer cells and brain microglial activation in Sanfilippo mice
Authors: Lau A. A. , Jin K. , Beard H. , Windram T. , Xie K. , O’Brien J. A. , Neumann D. , King B. M. , Snel M. F. , Trim P. J. , Mitrofanis J. , Hemsley K. M. , Austin P. J. 
Published: June 2024

AbstractSanfilippo syndrome results from inherited mutations in genes encoding lysosomal enzymes that catabolise heparan sulfate (HS), leading to early childhood‐onset neurodegeneration. This study explores the therapeutic potential of photobiomodulation (PBM), which is neuroprotective and anti‐inflammatory in several neurodegenerative diseases; it is also safe and PBM devices are readily available. We investigated the effects of 10–14 days transcranial PBM at 670 nm (2 or 4 J/cm2/day) or 904 nm (4 J/cm2/day) in young (3 weeks) and older (15 weeks) Sanfilippo or mucopolysaccharidosis type IIIA (MPS IIIA) mice. Although we found no PBM‐induced changes in HS accumulation, astrocyte activation, CD206 (an anti‐inflammatory marker) and BDNF expression in the brains of Sanfilippo mice, there was a near‐normalisation of microglial activation in older MPS IIIA mice by 904 nm PBM, with decreased IBA1 expression and a return of their morphology towards a resting state. Immune cell immunophenotyping of peripheral blood with mass cytometry revealed increased pro‐inflammatory signalling through pSTAT1 and p‐p38 in NK and T cells in young but not older MPS IIIA mice (5 weeks of age), and expansion of NK, B and CD8+ T cells in older affected mice (17 weeks of age), highlighting the importance of innate and adaptive lymphocytes in Sanfilippo syndrome. Notably, 670 and 904 nm PBM both reversed the Sanfilippo‐induced increase in pSTAT1 and p‐p38 expression in multiple leukocyte populations in young mice, while 904 nm reversed the increase in NK cells in older mice. In conclusion, this is the first study to demonstrate the beneficial effects of PBM in Sanfilippo mice. The distinct reduction in microglial activation and NK cell pro‐inflammatory signalling and number suggests PBM may alleviate neuroinflammation and lymphocyte activation, encouraging further investigation of PBM as a standalone, or complementary therapy in Sanfilippo syndrome.image