bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical actionability of BRCA2 alterations in uterine leiomyosarcoma: a molecular tumor board case report and a cBioPortal comprehensive analysis
Authors: Boscolo Bielo Luca , Repetto Matteo , Crimini Edoardo , Belli Carmen , Setola Elisabetta , Parma Gabriella , Fusco Nicola , Barberis Massimo , Guerini Rocco Elena , Marra Antonio , Colombo Nicoletta , Curigliano Giuseppe 
Published: May 2024

Abstract

Background
Uterine leiomyosarcoma (uLMS) represents one of the most common sarcoma histotypes, demonstrating an overall dismal prognosis. Previous studies reported uLMS to carry recurrent somatic BRCA2 homozygous deletions, related to significant clinical benefits from the use of PARP inhibitors.

Methods
To investigate the prevalence in uLMS of genomic alterations (alt) in BRCA2 and other homologous recombination (HR) and DNA damage response (DDR) genes, cBioPortal was accessed and data were retrieved from studies including pan-sarcoma histologies. HR-/DDR-genes included BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, NBN, PALB2, RAD51C, RAD51D, RAD50, and ATR. Only oncogenic/likely oncogenic alterations were included according to OncoKB.

Clinical Report and Results
We reported a clinical case of a patient affected by a highly pretreated uLMS discussed at the European Institute of Oncology Molecular Tumor Board. A targeted next-generation sequencing panel demonstrated a somatic BRCA2 homozygous deletion (homDel). Upon access to Niraparib, a remarkable response of 15 months was observed before experiencing disease progression. In the genomic query, among 2393 cases, uLMS (n = 193) displayed 9 of all 31 BRCA2alt observed, representing the only sarcoma histotype showing an enrichment in BRCA2alt (4.66%; q &lt; 0.001). All of 9 BRCA2alt were represented by homDel, which related to a high fraction of genome altered.

Conclusion
uLMS displays a significant frequency of somatic BRCA2alt homDel. Considering their dismal prognosis, further investigation is warranted to test the use of PARPi in uLMS, and particularly in the setting of BRCA1/2 alterations.
Hirundo rustica (Barn Swallows) and Tachycineta bicolor (Tree Swallows) select wetlands in agriculturally intensive landscapes, as revealed by GPS tracking
Authors: Harris Mercy E , Hobson Keith A , Morrissey Christy A 
Published: May 2024

Abstract
Aerial insectivorous birds breeding in North America have experienced decades of population declines for reasons hypothesized to be related to changes in their insect prey. In agricultural landscapes, land management practices can affect insect communities, leading to concerns that ongoing trends toward more intensive cultivation could affect the ability of farmland-breeding aerial insectivores to forage and provision their offspring with aerial insect prey. To understand how differences in agricultural intensity may affect the foraging behavior of different aerial insectivore species, we used GPS tags to compare the movements and habitat use of 2 species with different foraging ecologies, Hirundo rustica (Barn Swallow) and Tachycineta bicolor (Tree Swallow), breeding at 17 sites in agricultural landscapes in Saskatchewan, Canada. Although we identified differences in foraging behavior consistent with each species’ reported ecological traits, including T. bicolor foraging farther and over larger areas than H. rustica, overall foraging behavior was similar between species. Resource selection function analyses indicated that both species used wetlands disproportionately often relative to local wetland availability, especially when detected farther from their nests. Hirundo rustica and T. bicolor both also avoided cropped foraging habitat, using it proportionally less than it was locally available. In landscapes with greater wetland cover, both species selected for wetland habitat more strongly, and among T. bicolor, higher wetland density decreased maximum foraging distance and home range area. In contrast, we found no effect of crop cover on foraging habitat selection or foraging movements. These findings suggest that H. rustica and T. bicolor breeding in Saskatchewan agroecosystems share similar foraging strategies, with wetland habitats appearing to be highly important despite comprising only a small proportion of landscape area. Overall, these results indicate that protecting wetland habitats should be a priority for aerial insectivore conservation in the intensive agricultural landscapes such as the Canadian prairies.
Disjoint Dunford–Pettis-Type Properties in Banach Lattices
Authors: Botelho Geraldo , Luiz José Lucas P , Miranda Vinícius C C 
Published: May 2024

ABSTRACT
New characterizations of the disjoint Dunford–Pettis property of order p (disjoint DPPp) are proved and applied to show that a Banach lattice of cotype p has the disjoint DPPp whenever its dual has this property. The disjoint Dunford–Pettis$^*$ property of order p (disjoint $DP^*P_p$) is thoroughly investigated. Close connections with the positive Schur property of order p, with the disjoint DPPp, with the p-weak $DP^*$ property and with the positive $DP^*$ property of order p are established. In a final section, we study the polynomial versions of the disjoint DPPp and of the disjoint $DP^*P_p$.
Effect of extended days on feed on carcass gain, efficiency, and quality of individually fed beef steers
Authors: Sperber Jessica L , Bondurant Robby G , Erickson Galen E , Bruns Kelly , Funston Rick N , MacDonald Jim C 
Published: May 2024

Abstract
Crossbred steers (n = 114, initial BW = 334 kg; SEM = 5 kg) were serially harvested to evaluate the change in carcass composition by feeding cattle 21 or 42 d longer than the 2014 industry average subjective measure of finish, 1.27 cm of 12th rib fat thickness. Carcass ultrasound measurements were collected on 76 steers at 1, 78, and 134 days on feed (DOF) to project appropriate harvest date. Steers were sorted into three harvest groups, and serially harvested at 142, 163, or 185 DOF, with the first harvest date selected based on an estimated 12th rib fat thickness of 1.27 cm via ultrasound measurement. Steers were fed using an individual animal feeding system, to determine individual performance metrics. Steer DMI did not differ (P ≥ 0.31) between harvest groups, while carcass-adjusted ADG and G:F decreased linearly (P ≤ 0.04) as DOF increased. Carcass weight increased linearly (P &lt; 0.01) as DOF increased from 142 to 185 DOF, with steers gaining an additional 36 kg of HCW when fed an additional 42 DOF. Carcass LM area quadratically increased (P = 0.04) to 163 DOF and remained constant to 185 DOF. Marbling score was not different (P = 0.14) between harvest groups; however, the opportunity to grade USDA Premium Choice was improved for steers fed to 185 DOF. Calculated YG and 12th rib fat thickness increased linearly (P &lt; 0.01) as DOF increased, with distributions across YG 1 through 5 differing between harvest groups (P &lt; 0.01), and 185-d carcasses having the greatest frequency of YG 4 carcasses. As cattle are fed for additional DOF, live ADG and G:F decline, while HCW and LM area increase.
The usefulness of patient-reported outcome measures in decision making in Chagas cardiomyopathy: a scoping review
Authors: Silva Whesley Tanor , Silva Keity Lamary Souza , Xavier Diego Mendes , Ribeiro Ávila Matheus , de Oliveira Lucas Frois Fernandes , Colicchio Vittor de Moura , de Almeida Igor Lucas Geraldo Izalino , Bastone Alessandra de Carvalho , Alcantara Marcus Alessandro , Lacerda Ana Cristina Rodrigues , Lima Vanessa Pereira , de Oliveira Luciano Fonseca Lemos , Mediano Mauro Felippe Felix , Figueiredo Pedro Henrique Scheidt , Costa Henrique Silveira 
Published: May 2024

Abstract
Chagas cardiomyopathy (ChC) presents many biopsychosocial complexities, highlighting the need to have patient self-report questions. This study demonstrates the scope of the use of patient-reported outcome measures (PROMs) in patients with ChC and highlights the main research gaps. This is a scoping review and the search strategy was performed in the Online Medical Literature Analysis and Retrieval System (MEDLINE), Excerpta Medica database (EMBASE), Accumulated Index of Nursing and Allied Health Literature (CINAHL), Cochrane Central, Latin American Literature and Caribbean in Health Sciences (LILACS) and Diagnostic Test Accuracy (DITA). The search identified 4484 studies and 20 studies met the inclusion criteria. The Short-Form of 36 items (SF-36) had potential prognostic value and the ability to identify systolic dysfunction. The Human Activity Profile was able to screen for functional impairment, and the New York Heart Association showed potential prognostic value. The SF-36 and Minnesota Living with Heart Failure Questionnaire were responsive to interventions. The pharmaceutical care affected adherence to treatment as assessed by the Morisky score and also for SF-36. Despite the increased use of PROMs, there are still a large number of gaps in the literature, and further studies using PROMs are needed.
Comparing the effects of dual-task training and single-task training on walking, balance and cognitive functions in individuals with Parkinson’s disease: A systematic review
Authors: Lin Xiaoying , Zhang Yanming , Zhang Xiaowei , Chen Xi , Liu Jianhua , Yang Lei , Pang Marco Yiu Chung 
Published: May 2024

Abstract

Background:
This systematic review aimed to examine whether dual-task (DT) training was superior to single-task (ST) training in improving DT walking, balance and cognitive functions for individuals with Parkinson’s disease (PD).

Methods:
Literature search was performed in the following electronic databases: PubMed, the Cochrane Library, Web of Science, and Metstr covering inception to May 10, 2023. And in order to facilitate comparison across trials, we calculated the effect size (Hedges’ g) of gait, balance, cognitive, and other parameters under both ST and DT conditions, using the mean change score and standard deviation (SD) of change score of the experimental and control groups. Randomized controlled trials that examined the effects of DT motor and cognitive training in individuals with Parkinson’s disease were included for this systematic review.

Results:
A total of 214 participants recruited from six articles (actually five trials) were involved in this review. In terms of walking ability, only double support time and stride time variability showed significant between-group difference (Hedges’ g = 0.34, 0.18, respectively). Compared to ST training group, DT training group had a more improvement effect in laboratory balance measurement (Hedges’ g = 0.18, 1.25), but no significant improvement in clinical balance measurement. No significant between-group differences were observed, thus its training effect on cognitive function was inconclusive.

Conclusions:
The DT training failed to achieve promising results better than ST training in improving DT walking and balance functions for individuals with PD. Any firm conclusion cannot be drawn at present, due to the limited number of eligible publications. Larger sample size and high-quality studies are needed to investigate the effectiveness of DT training in individuals with PD.
Evaluation of a Scripture Integration Course for Christian Health Professions Faculty
Authors: Etcher LuAnn , Bauce Karen , Finger Reginald 
Published: May 2024

ABSTRACT:
The integration of Scripture in learning is an important focal element for education at Christian universities. A team of health professions faculty members from four universities belonging to the Council for Christian Colleges and Universities designed, developed, and facilitated a 9-week Scriptural Integration course for health professions faculty teaching at Christian universities. Participants completed the fully online asynchronous course, then completed a post-course survey. Survey responses help reveal what Christian university health professions faculty find useful and applicable in the integration of Scripture in learning.
Ferulic acid reduces inflammatory response induced by radiation through Sirt1-NLRP3 pathway
Authors: Nie Yao , Huang Mingyue , Yang Tingyu , Mei Yu , Zhang Huiting , Wei Xue , Gao Yue , Ma Zengchun 
Published: May 2024

Objective:
A model of inflammatory damage was induced by radiation to investigate whether ferulic acid (FA) can reduce the inflammatory response through the Sirt1-NLRP3 inflammatory pathway. This will help discover radiation-protective drugs and elucidate the molecular mechanisms related to radiation-induced inflammatory damage.

Methods:
A mouse model of radiation-induced immunoinflammatory injury was established to verify the anti-inflammatory effects of FA in vivo. C57BL/6J mice were randomly divided into six groups, and 5 Gy whole-body irradiation was used for modeling. Mice were administered a gastric solvent, amifostine, or 25, 50, or 100 mg/kg FA daily for 12 days, consecutively, before irradiation. The serum of mice was collected 24 hour after irradiation to observe the content of inflammatory factors interleukin (IL)-1β, IL-18, IL-6, and tumor necrosis factor (TNF)-α. The spleen and thymus tissues of mice were weighed and the organ index was calculated for pathological testing and immunofluorescence detection.

Results:
FA reduced the radiation-induced decrease in the spleen and thymus indices. FA significantly reduced the secretion of inflammatory factors in the serum and reversed the radiation-induced reduction in lymphocytes in the spleen and thymus of mice. FA activated Sirt1 and inhibited the expression of the NLRP3 inflammasome to alleviate the inflammatory response.

Conclusions:
FA reduced radiation-induced inflammation in animals, possibly by activating Sirt1 and reducing nucleotide oligomerization domain (NOD)-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome expression, thereby reducing the secretion of inflammatory factors.
Clinical and Optical Coherence Tomography Features of Subretinal Fibrin Glue after Glue-Assisted Vitrectomy for Rhegmatogenous Retinal Detachment Repair. GUARD Study – Report 3:
Authors: Ramachandran Aiswarya , Sadda SriniVas , Tyagi Mudit 
Published: May 2024

Purpose:
To highlight the clinical and optical coherence tomography (OCT) features of subretinal fibrin glue and its resolution over time in patients who have undergone glue- assisted retinopexy for Rhegmatogenous Retinal Detachments (RRD).

Methods:
A report of 2 cases with subretinal migration of fibrin glue. Both the cases were assessed with clinical examination, serial fundus photos and serial OCT scans through the area of subretinal fibrin immediately after surgery, at 1 week, 2 weeks and at 6 weeks.

Results:
In both the cases of intraoperative subretinal glue migration during glue-assisted vitrectomy for RRD repair, the subretinal glue had a characteristic appearance and course of evolution. On examination and color photography, the glue had an amorphous whitish appearance with wispy edges. This corresponded to subretinal hyperreflective material (SHRM) on OCT with a layered appearance. By two weeks after surgery, the subretinal glue demonstrated substantial regression on retinal examination and on OCT scans. At 6 weeks visit, the entire glue was noted to be resorbed along with an intact photoreceptor outer segments/Ellipsoid Zone layer

Conclusion:
In summary, this report describes the clinical and OCT appearance of subretinal migration of fibrin glue. Subretinal fibrin appears whitish on examination and corresponds to layered SHRM without shadowing on OCT. It appears to resorb spontaneously within weeks with apparent recovery of the overlying photoreceptors.
Establishment and Verification of an Artificial Intelligence Prediction Model for Children With Sepsis
Authors: Wang Li , Wu Yu-Hui , Ren Yong , Sun Fan-Fan , Tao Shao-Hua , Lin Hong-Xin , Zhang Chuang-Sen , Tang Wen , Chen Zhuang-Gui , Chen Chun , Zhang Li-Dan 
Published: May 2024

Background:
Early identification of high-risk groups of children with sepsis is beneficial to reduce sepsis mortality. This article used artificial intelligence (AI) technology to predict the risk of death effectively and quickly in children with sepsis in the pediatric intensive care unit (PICU).

Study Design:
This retrospective observational study was conducted in the PICUs of the First Affiliated Hospital of Sun Yat-sen University from December 2016 to June 2019 and Shenzhen Children’s Hospital from January 2019 to July 2020. The children were divided into a death group and a survival group. Different machine language (ML) models were used to predict the risk of death in children with sepsis.

Results:
A total of 671 children with sepsis were enrolled. The accuracy (ACC) of the artificial neural network model was better than that of support vector machine, logical regression analysis, Bayesian, K nearest neighbor method and decision tree models, with a training set ACC of 0.99 and a test set ACC of 0.96.

Conclusions:
The AI model can be used to predict the risk of death due to sepsis in children in the PICU, and the artificial neural network model is better than other AI models in predicting mortality risk.
Statistical modeling of acute and chronic pain patient-reported outcomes obtained from ecological momentary assessment
Authors: Leroux Andrew , Crainiceanu Ciprian , Zeger Scott , Taub Margaret , Ansari Briha , Wager Tor D. , Bayman Emine , Coffey Christopher , Langefeld Carl , McCarthy Robert , Tsodikov Alex , Brummet Chad , Clauw Daniel J. , Edwards Robert R. , Lindquist Martin A. ,   ; A2CPS Consortium
Published: May 2024

Abstract
Ecological momentary assessment (EMA) allows for the collection of participant-reported outcomes (PROs), including pain, in the normal environment at high resolution and with reduced recall bias. Ecological momentary assessment is an important component in studies of pain, providing detailed information about the frequency, intensity, and degree of interference of individuals' pain. However, there is no universally agreed on standard for summarizing pain measures from repeated PRO assessment using EMA into a single, clinically meaningful measure of pain. Here, we quantify the accuracy of summaries (eg, mean and median) of pain outcomes obtained from EMA and the effect of thresholding these summaries to obtain binary clinical end points of chronic pain status (yes/no). Data applications and simulations indicate that binarizing empirical estimators (eg, sample mean, random intercept linear mixed model) can perform well. However, linear mixed-effect modeling estimators that account for the nonlinear relationship between average and variability of pain scores perform better for quantifying the true average pain and reduce estimation error by up to 50%, with larger improvements for individuals with more variable pain scores. We also show that binarizing pain scores (eg, <3 and ≥3) can lead to a substantial loss of statistical power (40%-50%). Thus, when examining pain outcomes using EMA, the use of linear mixed models using the entire scale (0-10) is superior to splitting the outcomes into 2 groups (<3 and ≥3) providing greater statistical power and sensitivity.
Probing white matter microstructure in youth with chronic pain and its relation to catastrophizing using neurite orientation dispersion and density imaging
Authors: Timmers Inge , Biggs Emma E. , Bruckert Lisa , Tremblay-McGaw Alexandra G. , Zhang Hui , Borsook David , Simons Laura E. 
Published: May 2024

Abstract
Chronic pain is common in young people and can have a major life impact. Despite the burden of chronic pain, mechanisms underlying chronic pain development and persistence are still poorly understood. Specifically, white matter (WM) connectivity has remained largely unexplored in pediatric chronic pain. Using diffusion-weighted imaging, this study examined WM microstructure in adolescents (age M = 15.8 years, SD = 2.8 years) with chronic pain (n = 44) compared with healthy controls (n = 24). Neurite orientation dispersion and density imaging modeling was applied, and voxel-based whole-white-matter analyses were used to obtain an overview of potential alterations in youth with chronic pain and tract-specific profile analyses to evaluate microstructural profiles of tracts of interest more closely. Our main findings are that (1) youth with chronic pain showed widespread elevated orientation dispersion compared with controls in several tracts, indicative of less coherence; (2) signs of neurite density tract-profile alterations were observed in several tracts of interest, with mainly higher density levels in patients; and (3) several WM microstructural alterations were associated with pain catastrophizing in the patient group. Implicated tracts include both those connecting cortical and limbic structures (uncinate fasciculus, cingulum, anterior thalamic radiation), which were associated with pain catastrophizing, as well as sensorimotor tracts (corticospinal tract). By identifying alterations in the biologically informative WM microstructural metrics orientation dispersion and neurite density, our findings provide important and novel mechanistic insights for understanding the pathophysiology underlying chronic pain. Taken together, the data support alterations in fiber organization as a meaningful characteristic, contributing process to the chronic pain state.
Predictors of cardiovascular risk in familial hypercholesterolemia
Authors: Romero-Jiménez Manuel Jesús , Mansilla-Rodríguez María Elena 
Published: May 2024

Purpose of review
Familial Hypercholesterolemia is associated with an increased risk of cardiovascular disease. The current international guidelines of the main scientific societies consider that all people with familial hypercholesterolemia have a high or very high cardiovascular risk. However, the occurrence of atherosclerotic cardiovascular disease is very heterogeneous in this population. Stratifying risk within people with familial hypercholesterolemia is essential to identify individuals who require intensive cholesterol-lowering therapies.

Recent findings
In the last year, several studies have been published focusing on the contribution of diabetes to familial hypercholesterolemia, the role of stroke, as a manifestation of atherosclerotic disease, and the external validation of the SAFEHEART risk equation in the English population diagnosed with Familial Hypercholesterolemia.

Summary
It is necessary the development of a tool that allows us to identify, in a simple, reproducible, and universal way, patients who may have a high risk of suffering a cardiovascular event and who are susceptible to more intensive treatments to reduce cholesterol levels.