bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of chronic renal insufficiency on clinical outcomes in patients undergoing saphenous vein graft intervention with drug‐eluting stents: A multicenter Southern Californian Registry
Authors: Lee Michael S. , Hu Patrick P. , Aragon Joseph , Shah Atman , Bhatia Ravi , Jones Nathaniel , Penny William , French William , Tobis Jonathan , Mahmud Ehtisham 
Published: June 2010

AbstractObjectives: To evaluate the clinical outcomes in patients with chronic renal insufficiency (CRI) who undergo saphenous vein graft (SVG) intervention with drug‐eluting stents (DES). Background: Patients with CRI have higher rates of major adverse cardiac events (MACE) after percutaneous revascularization. SVG intervention is associated with increased rates of MACE compared with percutaneous revascularization of native arteries. However, the impact of CRI on SVG intervention with DES has not been well delineated. Methods: Consecutive patients who underwent SVG intervention with DES at five medical centers from April 2003 to December 2007 were included in this analysis. Results: A total of 172 patients, 39 patients with CRI and a serum creatinine ≥1.5 mg dL−1, and 133 patients without CRI, underwent SVG intervention with DES. Patients with CRI were more often older, diabetic, and had a longer mean total stent length. At 1 year, patients with CRI had a higher MACE rate (35.9% vs. 15.8%, hazard ratio [HR] 2.48, 95% confidence interval [CI] 1.26–4.88, log rank P = 0.009), mainly driven by higher mortality (20.5% vs. 9.8%, HR 3.41, 95% CI 1.10–10.58, log rank P = 0.024). There was a trend toward higher rates of target vessel revascularization in the CRI group (21.8% vs. 10.3%, HR 2.42, 95% CI 0.94–6.24, log rank P = 0.059). Stent thrombosis rates were not different between patients with and without CRI (2.6% vs. 2.3%, P = 0.8). Multivariable analysis revealed that CRI was the only significant predictor of 1‐year MACE (HR 2.2, 95% CI 1.1–4.3; P = 0.03). Conclusions: Patients with CRI who underwent SVG intervention with DES had higher risks of MACE and death compared with patients with preserved renal function. Further treatment strategies are needed in this high‐risk group who undergo SVG intervention with DES. © 2010 Wiley‐Liss, Inc.
A novel method of hybrid intraoperative catheter‐based closure of ventricular septal defects using the Amplatzer® PDA occluder
Authors: Neukamm Christian , Bjørnstad Per G. , Fischer Gunther , Smevik Bjarne , Lindberg Harald L. 
Published: June 2010

AbstractBackground: In five patients, an apical muscular septal defect was closed in a hybrid approach using the Amplatzer® duct occluder during open heart surgery, whereas concomitant defects were treated surgically. In addition to their different heart defects that needed surgery, all had a muscular ventricular septal defect in the apex of the heart, poorly accessible for traditional, surgical approach. We describe the method and outcome in these patients. Methods: The tip of a forceps was advanced from the left into the right ventricle through the ventricular septal defect. The delivery sheath was caught under visual control in the right ventricle and pulled back into the left ventricle. The disc was developed and pulled back until it was felt tugging at the septum. Then the core was developed. The end of the device was visible in the right ventricle and was secured with a Prolene® suture. Results: The procedures were event‐free. During early follow‐up there were either no or only insignificant shunts in the region of the prior trabecular defects in four patients. The unsatisfactory result in the last patient was caused by inaccurate preoperative assessment. Conclusion: The method seems valuable in patients in need of other intracardiac surgery. © 2010 Wiley‐Liss, Inc.
Intracardiac echocardiography off piste? Closure of the left atrial appendage using ICE and local anesthesia
Authors: MacDonald Simon T. , Newton James D. , Ormerod Oliver J. 
Published: June 2010

AbstractLeft atrial appendage (LAA) occlusion is increasingly accepted to reduce the risk of stroke in patients with atrial arrhythmia who are unsuitable for routine anticoagulation. It is generally performed under general anesthesia, guided by transoesophageal echocardiography with accurate imaging being essential for correct deployment of the device. We present a case where LAA occlusion was done under local anesthesia in a high‐anesthetic risk patient, using novel placement of an intracardiac echo probe via a Mullins sheath in the right ventricular outflow tract and pulmonary artery. This allowed accurate visualization of device deployment in the LAA. This technique may increase the spectrum of patients who may benefit from the procedure and decrease procedure time, fluoroscopy, and procedure‐related morbidity. © 2010 Wiley‐Liss, Inc.
Bailout perventricular pulmonary valve implantation following failed percutaneous attempt using the Edwards Sapien transcatheter heart valve
Authors: Cubeddu Roberto J. , Hijazi Ziyad M. 
Published: June 2010

AbstractPercutaneous pulmonary valve implantation has emerged as an attractive and less invasive alternative to open‐heart surgery. Nevertheless, major technical challenges and procedural complications may still occur. We report a 44‐year‐old woman with severe dextroscoliosis, and history of Tetralogy of Fallot repair, who underwent an attempt at percutaneous implantation of a 23‐mm Edwards SAPIEN transcatheter heart valve (THV) for recurrent stenosis of the right ventricle to pulmonary artery conduit. The procedure was complicated by valve migration into the right ventricle requiring emergent surgical removal using inflow‐occlusion technique to avoid cardiopulmonary bypass. A hybrid off‐pump perventricular approach was then used in the operating room to successfully implant a 26‐mm Edwards Sapien THV under fluoroscopic guidance. © 2010 Wiley‐Liss, Inc.
Aortic annulus evaluation in transcatheter aortic valve implantation
Authors: Hutter Andrea , Opitz Anke , Bleiziffer Sabine , Ruge Hendrik , Hettich Ina , Mazzitelli Domenico , Will Albrecht , Tassani Peter , Bauernschmitt Robert , Lange Ruediger 
Published: June 2010

AbstractObjectives: We compared the annulus diameters measured by transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and dual‐source computed tomography (DSCT) before transcatheter aortic valve implantation (TAVI). Background: In TAVI correct evaluation of the aortic annulus is mandatory to choose the correct prosthesis type and size and to prevent complications. There is no gold standard for the assessment of aortic annulus diameters. Methods: Preoperative assessment of the aortic annulus with TTE, TEE, and DSCT was performed in 187 consecutive patients referred for TAVI between June 2007 and May 2009. Results: The mean aortic annuli were 22.6 ± 2.0 mm measured with DSCT, 22.3 ± 2.5 mm with TTE, and 22.9 ± 2.2 mm with TEE. Despite a strong correlation between the measurement techniques, relevant statistical spread occurred with differences up to 3 mm in all measurement methods. Inter‐ and intraobserver variability was good for TEE and less satisfactory for DSCT measurements. TEE measurements taken as decisive parameter for the implantation changed the implantation strategy in 15.5% of patients and did not show an increased rate of procedural complications. Conclusion: Despite a strong correlation, the measurement techniques for the aortic annulus show relevant statistical spread, consequently one measurement technique cannot definitely predict another. TEE measurements show a more satisfactory intra‐ and interobserver variability than DSCT. Taking TEE annulus measurements as decisive parameter for the implantation has an impact on the implantation strategy and is safe with a low rate of procedural complications. © 2010 Wiley‐Liss, Inc.
Coronary angiography is a better predictor of mortality than noninvasive testing in patients evaluated for renal transplantation
Authors: Enkiri Sean A. , Taylor Angela M. , Keeley Ellen C. , Lipson Lewis C. , Gimple Lawrence W. , Ragosta Michael 
Published: June 2010

AbstractObjectives: The goal of this study was to compare whether coronary angiography or noninvasive imaging more accurately identifies coronary artery disease (CAD) and predicts mortality in patients with end‐stage renal disease (ESRD) under evaluation for transplantation. Background: CAD is a leading cause of mortality in patients with ESRD. The optimal method for identifying CAD in ESRD patients evaluated for transplantation remains controversial with a paucity of prognostic data currently available comparing noninvasive methods to coronary angiography. Methods: The study cohort consisted of 57 patients undergoing both coronary angiography and stress perfusion imaging. Severe CAD was defined by angiography as ≥70% stenosis, and by noninvasive testing as ischemia in ≥1 zone. Follow‐up for all cause mortality was 3.3 years. Results: On noninvasive imaging, 63% had ischemia. On angiography, 40% had at least one vessel with severe stenoses. Abnormal perfusion was observed in 56% of patients without severe disease angiographically. Noninvasive imaging had poor specificity (24%) and poor positive predictive value (43%) for identifying severe disease. Angiography but not noninvasive imaging predicted survival; 3 year survival was 50% and 73% for patients with and without severe CAD by angiography (p<0.05). Conclusions: False positive scintigrams limited noninvasive imaging in patients with ESRD. Angiography was a better predictor of mortality compared with noninvasive testing. © 2010 Wiley‐Liss, Inc.
Percutaneous closure of a postero‐medial mitral paravalvular leak: The triple telescopic system
Authors: Yuksel Uygar Cagdas , Tuzcu E. Murat , Kapadia Samir R. 
Published: June 2010

AbstractParavalvular leaks (PVLs) still remain as a serious complication of heart valve surgery. The reported incidence of PVL is ∼ 3–12.5% and most of them become clinically manifest as worsening heart failure, hemolysis, and arrhythmias within the first 6 months. Surgical intervention is recommended for symptomatic patients, but high‐operative risk associated with the repeat procedures frequently prohibits the redo surgery for the older patients with multiple severe comorbidities. In view of the limitations of surgery, percutaneous closure techniques have been applied to PVLs with considerable achievement. However, the technique is still challenging due to the lack of specifically engineered instruments for the procedure and requires considerable operator expertise. In this case report, we presented a case of posteromedial mitral PVL, which was successfully closed using an innovative telescopic catheter system involving three different catheters. © 2010 Wiley‐Liss, Inc.
Stent malapposition caused by improper rewiring during left main intervention: The role of intravascular ultrasound in avoidance and management—A case report
Authors: Abdou Sayed M , Wu Chiung‐Jen 
Published: June 2010

AbstractThe optimal technique for bifurcation stenting of distal Left main (LM) lesions remains unestablished and controversial. Some techniques with superior stent apposition, such as culotte technique were supposed to be associated with lower rate of stent thrombosis. However, with culotte technique, the double‐stent layer at the carina and in the proximal part of the bifurcation, may lead to difficult or improper rewiring of the side branch before final kissing balloon postdilatation (KBP). We describe a case of distal LM disease associated with distal left circumflex (LCX) and posterior descending artery stenosis. During LM stenting using culotte technique, improper rewiring of LCX before final KBP caused malapposition of the inner sent layer at the mid part of LM. Despite the optimal angiographic result, intravascular ultrasound (IVUS) was able to detect stent malapposition and guided further management to achieve complete stent apposition. The present case indicates that IVUS is an essential tool for LM stenting particularly when applying double stent strategy requiring final rewiring before KBP. Moreover, we suggest that some tools, such as Crusade and Venture catheters, can be used to ensure proper rewiring and hence, prevent subsequent stent malapposition, which may lead to catastrophic complications such as early and late LM stent thrombosis. © 2011 Wiley‐Liss, Inc.
Impact of chronic total occlusions on markers of reperfusion, infarct size, and long‐term mortality: A substudy from the TAPAS‐trial
Authors: Lexis Chris P.H. , van der Horst Iwan C.C. , Rahel Braim M. , Lexis Monique A.S. , Kampinga Marthe A. , Gu Youlan L. , de Smet Bart J.G.L. , Zijlstra Felix 
Published: June 2010

AbstractObjectives: This study evaluated the impact of a chronic total occlusion (CTO) in a non‐infarct related coronary artery (IRA) on markers of reperfusion, infarct size, and long‐term cardiac mortality in patients with ST‐elevation myocardial infarction (STEMI). Background: A concurrent CTO in STEMI patients has been associated with impaired left ventricular function and outcome. However, the impact on markers of reperfusion is unknown. Methods: All 1,071 STEMI patients included in the TAPAS‐trial between January 2005 and December 2006 were used for this substudy. Endpoints were the association between a CTO in a non‐IRA and myocardial blush grade (MBG) of the IRA, ST‐segment elevation resolution (STR), enzymatic infarct size, and clinical outcome. Results: A total of 90 patients (8.4%) had a CTO. MBG 0 or 1 occurred more often in the CTO group (34.2% versus 20.6% (Odds Ratio [OR] 2.00, 95% confidence interval [CI]: 1.22–3.23, P = 0.006)). Incomplete STR occurred more often in the CTO group, (63.6% versus 48.2% [OR 1.96, 95% CI: 1.22–3.13, P = 0.005]). Median level of maximal myocardial‐band of creatinin kinase (CK‐MB) in the CTO group was 75 μg/l (IQR 28‐136) and 51 μg/l (IQR 18–97) in the no‐CTO group (P = 0.021). The presence of a CTO in a non‐IRA in STEMI patients was an independent risk factor for cardiac mortality (HR 2.41, 95% CI: 1.26–4.61, P = 0.008) at 25 months follow‐up. Conclusion: A CTO in a non‐IRA is associated with impaired reperfusion markers and impaired long‐term outcome in STEMI patients. © 2010 Wiley‐Liss, Inc.
An Integrated Fouling Monitoring Technique for a Water Treatment Microfiltration Process
Authors: Chen W.‐H. , Hsieh Y.‐H. , Tung K. L. , Li Y. L. , Lai S. C. , Lin N. J. 
Published: June 2010

AbstractAn integrated, online fouling monitoring technique that provides dynamic and real‐time information of membrane fouling during a water treatment membrane process was developed. This technique has preliminarily been demonstrated for monitoring particulate fouling in a water treatment microfiltration process using a single photo sensor. The results of the online dynamic analysis suggest that this technique provides in situ measurement of fouling layer thickness, dynamic analysis of the fouling layer structure, and monitoring of water quality during the membrane filtration process.
Effect of Volume Fraction of Material on Separation by Density Difference in a Liquid‐Fluidized Bed of Inert Particles
Authors: Tatemoto Y. , Ishii A. , Suzuki Y. , Higashino T. 
Published: June 2010

AbstractA liquid‐fluidized bed was used to separate a pure material from a mixture. A quantity of relatively large sized material was immersed in an inert‐particle fluidized bed and the behavior of materials was examined for different liquid velocities. In particular, the volume fraction of the material was varied and its effect on the separation characteristics was examined.The material floats on the inert‐particle fluidized bed when the density of the material is lower than the apparent density of the bed, regardless of the volume fraction of the material. The apparent density of the bed can be adjusted by changing the liquid velocity. The materials in the upper portion of the bed affect the properties of the bed below them, i.e., the void fraction decreases and the apparent density increases in the inert‐particle suspension when materials are present in the upper portion of the bed. Therefore, the materials float on the bed although the apparent density of the inert‐particle suspension obtained from the case without material is less than the density of the material at a relatively high volume fraction of material. This phenomenon occurs more easily for lighter and smaller materials. This means that small inert particles and low liquid velocities are the optimum operating conditions for the separation.
Accelerated Formulation Development for Nanomilled Active Pharmaceutical Ingredients Using a Screening Approach
Authors: Juhnke M. , Berghausen J. , Timpe C. 
Published: June 2010

AbstractIn order to enable the accelerated preclinical and clinical pharmaceutical development of formulations based on nanomilling, a screening media mill was developed and evaluated for the production of nanoparticulate active pharmaceutical ingredients (API). The screening media mill is based on the principle of a conventional planetary mill, equipped with up to 24 milling beakers of 0.05–1.0 mL individual milling chamber volume. The applicability of the screening media mill was evaluated by 0.7–12.8 mg naproxen (2 wt %) per batch with a nanomilling formulation known from the literature. A case study for the preclinical formulation development is presented, applying 42 screening experiments by one operator within 5 working days, using in total 110 mg API. Promising nanomilling formulations with median particle sizes below 200 nm could be identified, suitable for preclinical in vivo studies. A second case study for the early clinical development of another proprietary API showed the successful formulation development within 12 working days. Up‐scaling to a miniaturized stirred media mill of 10 mL milling chamber volume resulted in a satisfying comparability of the selected formulations, with varying performance. Further up‐scaling of the most promising formulation to a laboratory‐scale stirred‐media mill showed the successful production of 250 g API with a median particle size of 140 nm.
Procedural Investigations of the Lautering Process
Authors: Tippmann J. , Scheuren H. , Voigt J. , Sommer K. 
Published: June 2010

AbstractBeer production begins in the brewhouse, where milled malt is mixed with water. Relevant ingredients of the malt are converted and dissolved into wort. The solids have to be separated from the remaining liquid. This step is done in the lauter tun and is still a very time‐consuming process. Additionally, the procedural knowledge of this production step is still rather poor. Another aim in beer production is the evaporation of unwanted aroma compounds. Usually this is done during wort boiling. The latest research showed that the preliminary steps should be done before boiling. The developed system is the result of these two principles, evaporation of unwanted flavoring substances and prevention of blocking of the filter cake. The approach was the integration of a bubble generator in the lauter tun, which blows nitrogen bubbles (inert gas, not oxidizing) through the mash and filter cake.
Dead‐End Liposomal Electro‐Filtration: Phenol Removal by Dioctadecyl Dimethyl Ammonium Chloride as a Case Study
Authors: Hakimhashem M. , Saveyn H. , De Bock B. , Van der Meeren P. 
Published: June 2010

AbstractAmong the important efforts that have been made for the removal of trace organic molecules, sorption by micelles and subsequent membrane filtration is a promising method which, however, still suffers from a number of disadvantages such as low efficiency and high energy consumption. In this article, we present the results of the sorption of phenol (as an important trace organic pollutant in industrial wastewater) to dioctadecyl dimethyl ammonium chloride (DODAC) liposomes, as well as the filtration properties of the resulting dispersion. Whereas the sorption of phenol by a 0.5 wt % DODAC dispersion at neutral pH and ambient temperature was only 26–35 %, it increased to above 95 % at pH 11. Applying an electric field during the filtration process considerably improved both the filtrate flow rate and the retention. An electric field of 5 V/cm increased the filtrate flow rate at 200 kPa 30‐fold.
Persistent Mixed‐Valence [(TTF)2]+. Dyad of a Chiral Bis(binaphthol)–tetrathiafulvalene (TTF) Derivative
Authors: Saad Ali , Barrière Frédéric , Levillain Eric , Vanthuyne Nicolas , Jeannin Olivier , Fourmigué Marc 
Published: June 2010

AbstractMixed‐valence dyadic [(TTF)2]+. (TTF=tetrathiafulvalene) species—the elementary building blocks of organic conductors—are usually too weakly associated to be observed in solution, unless covalently bound in dimers or physically constrained into a cage structure. We demonstrate here that a novel chiral tetrathiafulvalene functionalised with two 1,1′‐binaphthol units (1) is able to associate in solution into persistent mixed‐valence [(TTF)2]+. dyadic moieties through a stereospecific recognition pattern. This redox active molecule exhibits different electrochemical and spectroscopic responses, as enantiopure RR, SS or meso isomers, a rare example of a chiral system in which different diastereoisomers do not exhibit the same electrochemical features, with a selective formation of the mixed‐valence species in the enantiopure (RR)‐1 or (SS)‐1 isomers only, whereas the meso form does not show this association ability. A rationale for the selective self‐association of the RR and SS enantiomers upon oxidation is provided, based on the different molecular geometries and accessibility of the TTF core toward the formation of the mixed‐valence species.
Car–Parrinello Molecular Dynamics Study of the Thermal Decomposition of Sodium Fulminate
Authors: Damianos Konstantina , Frank Irmgard 
Published: June 2010

AbstractDepending on the metal cation, metal fulminates exhibit a characteristic sensitivity with respect to heat and mechanical stress. In the present paper we study the high‐temperature reactions of bulk sodium fulminate using Car–Parrinello molecular dynamics simulations. We find that the initiating reaction is the formation of the fulminate dimer, while in earlier studies an electron transfer was assumed to be the first reaction step. The initial carboncarbon bond formation is followed by fast consecutive reactions leading to polymerisation. The resulting species remain charged on the timescale of the simulations.
Deprotonative Metalation of Substituted Benzenes and Heteroaromatics Using Amino/Alkyl Mixed Lithium–Zinc Combinations
Authors: Snégaroff Katia , Komagawa Shinsuke , Chevallier Floris , Gros Philippe C. , Golhen Stéphane , Roisnel Thierry , Uchiyama Masanobu , Mongin Florence 
Published: June 2010

AbstractDifferent homoleptic and heteroleptic lithium–zinc combinations were prepared, and structural elements obtained on the basis of NMR spectroscopic experiments and DFT calculations. In light of their ability to metalate anisole, pathways were proposed to justify the synergy observed for some mixtures. The best basic mixtures were obtained either by combining ZnCl2⋅TMEDA (TMEDA=N,N,N′,N′‐tetramethylethylenediamine) with [Li(tmp)] (tmp=2,2,6,6‐tetramethylpiperidino; 3 equiv) or by replacing one of the tmp in the precedent mixture with an alkyl group. The reactivity of the aromatic lithium zincates supposedly formed was next studied, and proved to be substrate‐, base‐, and electrophile‐dependent. The aromatic lithium zincates were finally involved in palladium‐catalyzed cross‐coupling reactions with aromatic chlorides and bromides.
ChemInform Abstract: Gd2OSe2.
Authors: Tougait Olivier , Ibers James A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.