bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Electrical impedance tomography during open heart surgery and on the cardiac icu is feasible to monitor ventilation in children with congenital heart disease”
Authors: Clausen Jan-Christoph , Emeis Michael , Kleine-Brueggeney Maren , Cho Mi-Young , Kneyber Martin , Miera Oliver 
Published: May 2024

AbstractAlveolar de recruitment is a common problem during general anesthesia and operations. Pediatric cardiac surgery with cardiopulmonary Bypass is associated with interruption of ventilation and might enhance loss of Ventilation compared to other surgical procedures. Electrical impedance tomography (EIT) allows for monitoring of ventilation distribution and can be helpful in detecting pulmonary de recruitment. This case series demonstrates for the first time that EIT is feasible during open heart surgery and in patients with open chest on the ICU using adapted belts in pediatric patients. It might be helpful to monitor changes in tidal volume distribution, to detect loss of Ventilation during surgery and to guide recruitment maneuvers. Study registration: NCT06270485, clincialtrials.gov, 02/02/2024.
New materials of acanthomorphic acritarchs from the Ediacaran Weng'an Biota (South China)
Authors: Wu Junxian , Sun Weichen , Shang Xiaodong , Liu Pengju , Zhu Maoyan , Yin Zongjun 
Published: May 2024

AbstractThe Weng'an Biota from the Ediacaran Doushantuo Formation in Guizhou Province, southwestern China, is known for its three-dimensionally phosphatized acritarchs, multicellular algae, and embryo-like animal fossils. Among these diverse microfossils, acanthomorphic acritarchs have played a significant role in the biostratigraphic subdivision and correlation of the lower-middle Ediacaran System. However, most previous studies on the biostratigraphy of the Doushantuo Formation in the Weng'an area have focused on large acanthomorphic acritarchs (LAAs, vesicle diameter >200 μm), whereas the smaller acanthomorphic acritarchs (SAAs, vesicle diameter <100 μm) from the Weng'an Biota have been largely overlooked. In this study, we examined >500 thin sections and discovered a large number of well-preserved, small (<100 μm) and medium-sized acanthomorphic acritarchs (MAAs, vesicle diameter ranging 100–200 μm). In total, we have identified SAAs in four genera and six species (Tanarium conoideumKolosova, 1991, emend. Moczydłowska et al., 1993;Tanarium elegansLiu et al., 2014;Mengeosphaera membraniferaShang, Liu, and Moczydłowska, 2019;Mengeosphaera minimaLiu et al., 2014;Estrella rectaLiu and Moczydłowska, 2019;Variomargosphaeridium gracileXiao et al., 2014), as well as two types of MAAs (Tanarium tuberosumMoczydłowska, Vidal, and Rudavskaya, 1993, emend. Moczydłowska, 2015;Weissiellacf.W. grandistellaVorob'eva, Sergeev, and Knoll, 2009, emend. Liu and Moczydłowska, 2019). This updated acritarch assemblage of the Weng'an Biota is valuable for correlating the Ediacaran Doushantuo Formation between the Weng'an and Yangtze Gorges areas. It also serves as a tool to test the proposed acritarch biozones in Ediacaran formations of South China and other localities, including Australia, Siberia, and the East European Platform.
Subnanosecond Electromagnetic Pulse Generated by a Long Spark Discharge: Lightning Implication
Authors: Gushchin M. E. , Zudin I. Yu. , Vershinin I. M. , Mikryukov P. A. , Syssoev V. S. , Sukharevsky D. I. , Orlov A. I. , Naumova M. Yu. , Kuznetsov Yu. A. , Shvets N. N. , Mareev E. A. 
Published: May 2024

AbstractThe effects of generating pulsed radiation by a long spark discharge are important for the development of lightning models and applications related to lightning protection. In experiments with a Marx generator simulating a lightning discharge, we detected the radiation in the form of a single ultrawideband electromagnetic pulse (UWB EMP) about 200 ps in duration, and rising time about 100 ps. UWB EMP generation occurs during the breakdown of a “rod–rod” 4 m long gap. Pulses of almost unipolar shape are observed in more than half of all positive discharges. EMP emission occurs before the main stage, and corresponds to the start of the upward leader from a grounded electrode. In negative discharges, pulses are also observed, but less frequently and with a smaller amplitude. The UWB EMPs, given their large amplitude (more than 100 V/m at a distance of 90 m from the discharge), can be considered as possible new lightning damage factors.
Methanogenic Archaea as Catalysts for Magnetite Formation in Iron‐Rich Marine Sediments
Authors: Lin Zhiyong , Lin Haixin , Strauss Harald , Roberts Andrew P. , Niu Mingyang , Fang Yunxin , Yang Tao , Sun Xiaoming , Birgel Daniel , Peckmann Jörn 
Published: May 2024

AbstractFine‐grained authigenic magnetite has been recognized increasingly in iron‐rich marine environments affected by methane seepage and is a major sedimentary magnetization source. However, it is unknown whether this magnetite forms via microbial or abiotic processes. We report here abundant fine magnetite crystals, in close association with goethite, within coarse‐grained sediments from two adjacent methane seepage sites in the South China Sea. The magnetite‐ and goethite‐rich horizons have sharply increased Zr/Ti, Zr/Rb, Ti/Al, and Fe/Al ratios, probably reflecting deposition by turbidity currents. Deeper intervals have elevated pyrite content, positive δ34S excursions of chromium reducible sulfur, and low magnetic susceptibilities, which is consistent with past sulfate‐driven anaerobic oxidation of methane in environments with dynamically variable seepage intensity. In magnetically extracted aggregates (>63 μm), magnetite particles are mainly clustered euhedral crystals with 0.2–0.8 μm sizes, which will likely impact sedimentary magnetic signals. The fine, euhedral crystalline nature of the magnetite suggests formation in sulfide‐free, ferrous iron‐rich sedimentary environments. Based on 16S rRNA gene sequences, anaerobic methanotrophic archaea coincide with pyrite rich horizons. In contrast, two co‐occurring methanogenic archaea groups of the Methanomicrobia class (mainly Methanosarcina and Methanocella) are particularly abundant in turbidites but have low abundance in all other horizons. Increased Methanomicrobia abundances suggest that this class of archaea may be involved in microbial iron reduction in turbidites with abundant goethite as a reactive iron source, and that they apparently trigger magnetite formation. Our findings provide new clues to microbial magnetite formation in iron‐rich marine sediments.
An Isotope Mass Balance Analysis of Evaporative Loss From Lake Turkana, Kenya Using δ18O and δD of Natural Waters
Authors: Saslaw M. , Yang D. , Lee D. , Poulsen C. J. , Henkes G. A. 
Published: May 2024

AbstractMeasurements of oxygen and hydrogen stable isotope ratios (δ18O and δD) in meteoric waters provide insight to overlapping effects of evaporation, precipitation, and mixing on basin scale hydrology. This study of waters collected between 2016 and 2021 in the Turkana Basin, northern Kenya, uses δ18O and δD to understand water balance in Lake Turkana, a large, low‐latitude, alkaline desert lake. The Omo River, a major river system in the Ethiopian Highlands, is historically understood to provide approximately 90% of the water input to Lake Turkana. Discharge of the Omo is prohibitively difficult to measure, but stable isotope ratios in the lake may provide a meaningful method for monitoring the lake's response to changes in input. Precipitation in the Turkana Basin is low (<200 mm/year) with negligible rainfall on the lake's surface, and all water loss from the lake is evaporative. We compare new measurements with previous data from the region and records of lake height and precipitation from the same time period. We show that a Bayesian approach to modeling evaporation using atmospheric conditions and river δ18O and δD yields results consistent with published water balance models. Continued sampling of lake and meteoric waters in the Turkana Basin will be a useful way to monitor the lake's response to regional and global climate change.
Revealing the EMIC Wave Frequency Differences in the Ionosphere via Coordinated Observations: A Case Study
Authors: Ouyang Xin‐Yan , Yue Chao , Wang Yong‐Fu , Ren Jie , Yang Mu‐Ping , Wang Ya‐Lu , Wu Ying‐Yan , Zhang Xue‐Min 
Published: May 2024

AbstractWe study electromagnetic ion cyclotron (EMIC) waves based on observations from the ionosphere, magnetosphere, and ground during a geomagnetic storm recovery phase on 28 August 2018. In this case, multiple ducting EMIC waves in the ionosphere show higher frequencies in the post‐midnight than those in the pre‐midnight. Ionospheric EMIC wave frequency differences in magnetic local time (MLT) are consistent with MLT frequency differences in the equatorial magnetosphere, which are mainly caused by different background magnetic field at different L‐shells. Moreover, we report the first observation of frequency range selections in ionospheric ducting EMIC waves and find that frequency selections depend on the magnetic field intensity in the main part of the ionospheric waveguide, with higher frequency corresponding to larger magnetic field. This study reveals the important role of background magnetic field in regulating ducting EMIC wave frequencies in the ionosphere.
A Pressure Pulse‐Driven Transient Magnetospheric Event
Authors: Sibeck D. G. , Lee S.‐H. 
Published: May 2024

AbstractBursty reconnection models predict that flux transfer events (FTEs) moving along the magnetopause launch fast mode compressional waves into the magnetosheath that push the bow shock outward. By contrast, increases in the solar wind density striking the bow shock should push that boundary inward and launch fast mode compressional waves that propagate across the magnetosheath, drive waves on the magnetopause, and generate transient events in the outer magnetosphere. Multipoint ACE, Wind, THEMIS, and GOES‐11/12 solar wind, bow shock, and magnetospheric observations on 14 October 2008 provide direct evidence for solar wind pressure pulses producing a large amplitude indentation with crater FTE‐like properties on the magnetopause.
Joint effects of traffic-related air pollution and hypertensive disorders of pregnancy on maternal postpartum depressive and anxiety symptoms
Authors: Hu Yuhong , Chavez Thomas , Eckel Sandrah P. , Yang Tingyu , Chen Xinci , Vigil Mario , Pavlovic Nathan , Lurmann Fred , Lerner Deborah , Lurvey Nathana , Grubbs Brendan , Al-Marayati Laila , Toledo-Corral Claudia , Johnston Jill , Dunton Genevieve F. , Farzan Shohreh F. , Habre Rima , Breton Carrie , Bastain Theresa M. 
Published: May 2024

Abstract
Background
Ambient air pollution has been linked to postpartum depression. However, few studies have investigated the effects of traffic-related NOx on postpartum depression and whether any pregnancy-related factors might increase susceptibility.

Objectives
To evaluate the association between traffic-related NOx and postpartum depressive and anxiety symptoms, and effect modification by pregnancy-related hypertension.

Methods
This study included 453 predominantly low-income Hispanic/Latina women in the MADRES cohort. Daily traffic-related NOx concentrations by road class were estimated using the California LINE-source dispersion model (CALINE4) at participants’ residential locations and averaged across pregnancy. Postpartum depressive and anxiety symptoms were evaluated by a validated questionnaire (Postpartum Distress Measure, PDM) at 1, 3, 6 and 12 months postpartum. Multivariate linear regressions were performed to estimate the associations at each timepoint. Interaction terms were added to the linear models to assess effect modification by hypertensive disorders of pregnancy (HDPs). Repeated measurement analyses were conducted by using mixed effect models.

Results
We found prenatal traffic-related NOx was associated with increased PDM scores. Specifically, mothers exposed to an IQR (0.22 ppb) increase in NOx from major roads had 3.78% (95% CI: 0.53–7.14%) and 5.27% (95% CI: 0.33–10.45%) significantly higher 3-month and 12-month PDM scores, respectively. Similarly, in repeated measurement analyses, higher NOx from major roads was associated with 3.06% (95% CI: 0.43–5.76%) significantly higher PDM scores across the first year postpartum. Effect modification by HDPs was observed: higher freeway/highway and total NOx among mothers with HDPs were associated with significantly higher PDM scores at 12 months postpartum compared to those without HDPs.

Impact
This study shows that prenatal traffic-related air pollution was associated with postpartum depressive and anxiety symptoms. The study also found novel evidence of greater susceptibility among women with HDPs, which advances the understanding of the relationships between air pollution, maternal cardiometabolic health during pregnancy and postpartum mental health. Our study has potential implications for clinical intervention to mitigate the effects of traffic-related pollution on postpartum mental health disorders. The findings can also offer valuable insights into urban planning strategies concerning the implementation of emission control measures and the creation of green spaces.
Characteristics of oral health of patients with X-linked hypophosphatemia: case reports and literature review
Authors: Arhar Ana , Pavlič Alenka , Hočevar Luka 
Published: May 2024

Abstract
Background
Oral health is impaired in X-linked hypophosphatemia (XLH), resulting in delayed dental development, malocclusion, and radiographic abnormalities. This study investigates the oral manifestations in Slovenian XLH patients, focusing on enamel and dentin abnormalities and a literature review of spontaneous periapical abscesses in XLH cases.

Objectives
To report XLH patients with specific oral signs and symptoms, histological analysis of affected teeth, and review of reported cases of XLH patients with spontaneous periapical abscesses.

Methods
Case reports: Seven XLH patients from the National Registry of Patients with Rare Diseases underwent a detailed oral examination, including X-ray reviews. The patients who were expected to have tooth exfoliation or extraction were asked to donate their teeth for histological analysis by scanning electron microscopy. Literature search: A literature search of four electronic databases and a manual bibliography search aimed to identify documented cases of XLH with periapical abscesses up to January 21, 2024. Inclusion criteria were confirmed XLH patients with periapical abscesses in English peer-reviewed publications.

Results
Tooth samples from three XLH patients showed reduced dentin mineralisation, affecting one-third to one-half of the outer dentin. Inadequate mineralisation, uneven dentin tubules, and cracks and chipping in the enamel were observed, indicating mineralisation deviations. Similar cracks extended into the dentin and were also present in the root of the examined tooth. Based on the content of the 75 items identified in the search, spontaneous abscesses are not uncommon in patients with XLH.

Conclusions
XLH significantly affects patients’ lives and requires lifelong treatment. Dental examinations consistently revealed oral problems, including malocclusion. Histological analysis confirmed structural changes, especially in the dentin. Despite continued treatment, XLH patients may have an increased risk of oral pathologies. Further research is needed to understand the impact of XLH and its treatment on dental health.
Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
Authors: Nath Karthik , Shekarkhand Tala , Nemirovsky David , Derkach Andriy , Costa Bruno Almeida , Nishimura Noriko , Farzana Tasmin , Rueda Colin , Chung David J. , Landau Heather J. , Lahoud Oscar B. , Scordo Michael , Shah Gunjan L. , Hassoun Hani , Maclachlan Kylee , Korde Neha , Shah Urvi A. , Tan Carlyn Rose , Hultcrantz Malin , Giralt Sergio A. , Usmani Saad Z. , Shahid Zainab , Mailankody Sham , Lesokhin Alexander M. 
Published: May 2024

AbstractB-cell-maturation-antigen (BCMA)-directed therapies are highly active for multiple myeloma, but infections are emerging as a major challenge. In this retrospective, single-center analysis we evaluated infectious complications after BCMA-targeted chimeric-antigen-receptor T-cell therapy (CAR-T), bispecific-antibodies (BsAb) and antibody-drug-conjugates (ADC). The primary endpoint was severe (grade ≥3) infection incidence. Amongst 256 patients, 92 received CAR-T, 55 BsAb and 109 ADC. The incidence of severe infections was higher with BsAb (40%) than CAR-T (26%) or ADC (8%), including grade 5 infections (7% vs 0% vs 0%, respectively). Comparing T-cell redirecting therapies, the incidence rate of severe infections was significantly lower with CAR-T compared to BsAb at 1-year (incidence-rate-ratio [IRR] = 0.43, 95%CI 0.25−0.76, P = 0.004). During periods of treatment-emergent hypogammaglobulinemia, BsAb recipients had higher infection rates (IRR:2.27, 1.31−3.98, P = 0.004) and time to severe infection (HR 2.04, 1.05–3.96, P = 0.036) than their CAR-T counterparts. During periods of non-neutropenia, CAR-T recipients had a lower risk (HR 0.44, 95%CI 0.21−0.93, P = 0.032) and incidence rate (IRR:0.32, 95% 0.17–0.59, P < 0.001) of severe infections than BsAb. In conclusion, we observed an overall higher and more persistent risk of severe infections with BsAb. Our results also suggest a higher infection risk during periods of hypogammaglobulinemia with BsAb, and with neutropenia in CAR-T recipients.
Imatinib with intensive chemotherapy in AML with t(9;22)(q34.1;q11.2)/BCR::ABL1. A DATAML registry study
Authors: Gondran Camille , Dumas Pierre-Yves , Bérard Emilie , Bidet Audrey , Delabesse Eric , Tavitian Suzanne , Leguay Thibaut , Huguet Françoise , Borel Cécile , Forcade Edouard , Vergez François , Vial Jean-Philippe , Rieu Jean Baptiste , Lechevalier Nicolas , Luquet Isabelle , Canali Alban , Klein Emilie , Sarry Audrey , de Grande Anne-Charlotte , Pigneux Arnaud , Récher Christian , Largeaud Laetitia , Bertoli Sarah 
Published: May 2024

AbstractAcute myeloid leukemia (AML) with t(9;22) (q34.1; q11.2)/BCR::ABL1, a distinct entity within the group of AML with defining genetic abnormalities, belong to the adverse-risk group of the 2022 ELN classification. However, there is little data on outcome since the era of tyrosine kinase inhibitors. Among 5819 AML cases included in the DATAML registry, 20 patients with de novo BCR::ABL1+AML (0.3%) were identified. Eighteen patients treated with standard induction chemotherapy were analyzed in this study. Imatinib was added to chemotherapy in 16 patients. The female-to-male ratio was 1.25 and median age was 54 years. The t(9;22) translocation was the sole chromosomal abnormality in 12 patients. Main gene mutations detected by NGS were ASXL1, RUNX1 and NPM1. Compared with patients with myeloid blast phase of chronic myeloid leukemia (CML-BP), de novo BCR::ABL1+AML had higher WBC, fewer additional chromosomal abnormalities, lower CD36 or CD7 expression and no ABL1 mutations. Seventeen patients (94.4%) achieved complete remission (CR) or CR with incomplete hematologic recovery. Twelve patients were allografted in first remission. With a median follow-up of 6.3 years, the median OS was not reached and 2-year OS was 77% (95% CI: 50–91). Four out of five patients who were not transplanted did not relapse. Comparison of BCR::ABL1+AML, CML-BP, 2017 ELN intermediate (n = 643) and adverse-risk patients (n = 863) showed that patients with BCR::ABL1+AML had a significant better outcome than intermediate and adverse-risk patients. BCR::ABL1+AML patients treated with imatinib and intensive chemotherapy should not be included in the adverse-risk group of current AML classifications.
Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications
Authors: Zhao Feng , Liu Feng , Gao Chenglong , Wang Guoqing , Zhang Yinfeng , Yu Fei , Tian Jiawei , Tan Kai , Zhang Runhao , Liang Kang , Lian Zhexun , Guo Junjie , Kong Biao , Ge Junbo , Xin Hui 
Published: May 2024

Abstract
Drug-eluting stents are a commonly used treatment for coronary artery disease. However, the coatings used in drug-eluting stents have some limitations such as poor biocompatibility and drug loading capacity. In recent years, self-assembly methods have emerged as a promising alternative for stent coatings. Self-assembled coatings employ biomaterials and offer several advantages over traditional coatings, including thinner thickness, stronger binding capacity, and better biocompatibility. This review discusses the latest research on self-assembled biomaterial-based coatings for drug-eluting stents. We explore how layer-by-layer coatings and composite coating films have been utilized to load and release drugs with high drug loading capacity and biocompatibility, as well as how they promote endothelial adhesion and growth. Additionally, we examine how self-assembled coatings have been used to release active molecules for anti-coagulation and deliver gene therapy. Moreover, we discuss the potential of self-assembled coatings for future development, including intelligent targeted drug delivery, bionic stent coatings, and 3D printed stent coatings. These advancements have the potential to further improve the effectiveness of drug-eluting stents in treating coronary artery disease.
Structural variant calling and clinical interpretation in 6224 unsolved rare disease exomes
Authors: Demidov German , Laurie Steven , Torella Annalaura , Piluso Giulio , Scala Marcello , Morleo Manuela , Nigro Vincenzo , Graessner Holm , Banka Siddharth ,   Solve-RD consortium, Macaya Alfons , Pérez-Dueñas Belén , Jackson Adam , Stevanin Giovanni , de Sainte Agathe Jean-Madeleine , Havlovicová Markéta , Horvath Rita , Pinelli Michele , van Os Nienke J. H. , van de Warrenburg Bart P. C. , Denommé-Pichon Anne-Sophie , Savarese Marco , Johari Mridul , Dallapiccola Bruno , Tartaglia Marco , Pauly Martje G. , Sommer Anna Katharina , Haack Tobias B. , Töpf Ana , Didier Lacombe , Fallerini Chiara , Renieri Alessandra , Chinnery Patrick F. , Natera-de Benito Daniel , Nascimento Andres , Trimouille Aurélien , Munell Francina , Marcé-Grau Anna , Rabah Ben Yaou , Bonne Gisèle , Van de Vondel Liedewei , Lohmann Katja , Ossowski Stephan 
Published: May 2024

AbstractStructural variants (SVs), including large deletions, duplications, inversions, translocations, and more complex events have the potential to disrupt gene function resulting in rare disease. Nevertheless, current pipelines and clinical decision support systems for exome sequencing (ES) tend to focus on small alterations such as single nucleotide variants (SNVs) and insertions-deletions shorter than 50 base pairs (indels). Additionally, detection and interpretation of large copy-number variants (CNVs) are frequently performed. However, detection of other types of SVs in ES data is hampered by the difficulty of identifying breakpoints in off-target (intergenic or intronic) regions, which makes robust identification of SVs challenging. In this paper, we demonstrate the utility of SV calling in ES resulting in a diagnostic yield of 0.4% (23 out of 5825 probands) for a large cohort of unsolved patients collected by the Solve-RD consortium. Remarkably, 8 out of 23 pathogenic SV were not found by comprehensive read-depth-based CNV analysis, resulting in a 0.13% increased diagnostic value.