bluuebunny/crossref_metadata_2025_split huggingface dataset:
What is the Efficiency of ATP Signaling from Erythrocytes to Regulate Distribution of O2 Supply Within the Microvasculature?
Authors: ELLIS CHRISTOPHER G. , MILKOVICH Stephanie , GOLDMAN Daniel 
Published: May 2012

Please cite this paper as: Ellis CG, Milkovich S, Goldman D. What is the efficiency of ATP signaling from erythrocytes to regulate distribution of O2 supply within the microvasculature? Microcirculation 19: 440–450, 2012.AbstractErythrocytes appear to be ideal sensors for regulating microvascular O2 supply as they release the potent vasodilator ATP in an O2 saturation‐dependent manner. Whether erythrocytes play a significant role in regulating O2 supply in the complex environment of diffusional O2 exchange among capillaries, arterioles, and venules, depends on the efficiency with which erythrocytes signal the vascular endothelium. If one assumes that the distribution of purinergic receptors is uniform throughout the microvasculature, then the most efficient site for signaling should occur in capillaries, where the erythrocyte membrane is in close proximity to the endothelium. ATP released from erythrocytes would diffuse a short distance to P2y receptors inducing an increase in blood flow, possibly the result of endothelial hyperpolarization. We hypothesize that this hyperpolarization varies across the capillary bed depending upon erythrocyte supply rate and the flux of O2 from these erythrocytes to support O2 metabolism. This would suggest that the capillary bed would be the most effective site for erythrocytes to communicate tissue oxygen needs. Electrically coupled endothelial cells conduct the integrated signal upstream where arterioles adjust vascular resistance, thus enabling ATP released from erythrocytes to regulate the magnitude and distribution of O2 supply to individual capillary networks.
Low Temperature Crystallization of Metastable Nickel Manganite Spinel Thin Films
Authors: Ko Song Won , Schulze Heidi M. , Saint John David B. , Podraza Nikolas J. , Dickey Elizabeth C. , Trolier‐McKinstry Susan S. 
Published: May 2012

Single‐phase metastable cubic spinel nickel manganite films, 0.5 ≤ Mn/(Mn+Ni) ≤ 0.8, were produced using chemical solution deposition. Of these, the sample with Mn/(Mn+Ni) = 0.80 showed the lowest electrical resistivity. Films annealed in Argon at 400°C for 5 h exhibit temperature coefficient of resistance values ranging from −3.81 to −3.93%/K and electrical resistivities of ~10 kΩ‐cm. It was found by transmission electron microscopy that the metastable spinel phase appeared in both pyrolyzed and post‐deposition annealed films. Spectroscopic ellipsometry measurements over the spectral range from 0.75 to 6.0 eV showed that the complex dielectric function spectra (ε = ε1 + iε2) varied as a function of the annealing conditions, due at least in part to changes in film density. Aging experiments have been used to identify variations in resistivity and temperature coefficient of resistance as functions of time to assess material stability. As a result, the aging coefficient was 6.5% for a film with Mn/(Ni+Mn) = 0.80 after aging at 150°C for 500 h.
An Ultra‐Broad Working Temperature Dielectric Material of BaTiO3‐Based Ceramics with Nd2O3 Addition
Authors: Li Lingxia , Guo Dong , Xia Wangsuo , Liao Qingwei , Han Yemei , Peng Yin 
Published: May 2012

An ultra‐broad working temperature dielectric material, BaTiO3–Na0.5Bi0.5TiO3–Nb2O5–MgO–Glass with Nd2O3 addition, was investigated for the first time. Microstructure and dielectric properties of the well‐sintered samples were studied. XRD results showed the formation of tetragonal perovskite and the presence of a second phase of NaBiTi6O14. It is found that the addition of Nd2O3 produces a decrease in tetragonality of perovskite structure which could be interpreted by the substitution of Nd3+ ions into Ti sites. Bulk densities and dielectric properties were measured as a function of Nd2O3 concentration. The 0.4 mol% Nd2O3‐doped sample showed the optimal dielectric performance (εr = 1445, tan δ<2.0%, ΔC/C ≤±12%) that satisfied EIA‐X9R specification. In particular, the ceiling working temperature was significantly enhanced from 200°C to 270°C by doping Nd2O3. Since it possesses large dielectric constant, low dielectric loss, and stable temperature character, this material shows promising applications for the ultra‐broad temperature range components, e.g., multilayer ceramic capacitors.
Protective effect of chromene isolated from Sargassum horneri against UV‐A‐induced damage in skin dermal fibroblasts
Authors: Kim Jung‐Ae , Ahn Byul‐Nim , Kong Chang‐Suk , Kim Se‐Kwon 
Published: May 2012

AbstractSkin homoeostasis is interrupted during UV‐A irradiation. How the UV‐A‐altered skin components influences photoageing of skin should be investigated using human in vitro models that are important for understanding skin ageing. In this study, chromene compound, sargachromenol, was isolated from Sargassum horneri, and its potency on inhibition of photoageing was investigated in UV‐A‐irradiated dermal fibroblasts. Effects of sargachromenol on the prevention of photoageing were evaluated by measuring ROS production, membrane protein oxidation, lipid peroxidation and ageing‐related gene expression in UV‐A‐irradiated human skin dermal fibroblasts. The results indicated that treatment with sargachromenol suppressed the collagenase matrix metalloproteinases (MMPs), MMP‐1, MMP‐2 and MMP‐9 expression without any cytotoxicity and phototoxicity. It was further found that these inhibitions were because of increase in the expression of TIMP‐1 and TIMP‐2 genes. Furthermore, we confirmed that the UV‐A‐induced transcriptions of AP‐1 signalling pathway were regulated by sargachromenol treatment in UV‐A‐irradiated dermal fibroblasts.
An assessment of periodontal health in patients with schizophrenia and taking antipsychotic medication
Authors: Eltas A , Kartalcı Ş , Eltas ŞD , Dündar S , Uslu MO 
Published: May 2012

Abstract:Background and objective: Severe periodontal disease is prevalent among patients with schizophrenia and is caused by the side effect of their medication, poor dental hygiene and smoking. The objective of this study was to evaluate whether the rate of periodontal disease could be modulated by changing the salivary flow rate (SFR) because of the use of antipsychotic medications in patients with schizophrenia.Methods: Group A (n = 33) included patients who used medications that may cause xerostomia, or dry mouth and Group B (n = 20) included patients who used medications that may cause sialorrhea, an excessive secretion of saliva. The participants’ periodontal status was assessed using the plaque index (PI), assessing bleeding on probing (BoP), probing pocket depth (PPD) and clinical attachment levels (CAL).Results: The mean of PI and BoP was significantly higher in Group A than in Group B (P < 0.001), but the PPD, CAL and decayed, missing and filled teeth (DMFT) scores were not significantly different in the two groups according to the statistical results (P > 0.05).Conclusions: The researcher concluded that there is a high risk of periodontal disease among patients with schizophrenia, and there is an even higher risk of periodontal disease induced by medication that increased SFR. Preventive dental protocol should be increased during the dental health care of this disadvantaged patient group.
Do thrombophilic gene mutations have a role on thromboembolic events in cancer patients?
Authors: OZKAN Metin , SIVGIN Serdar , KOCYIGIT Ismail , EMIROGULLARI Funda , DIKILITAS Mustafa , KAYNAR Leylagul , OZKUL Yusuf , ER Ozlem 
Published: May 2012

AbstractAim:  Thromboembolism is common in patients with cancer and may be considered a major cause of morbidity and mortality. We studied the most common genetic polymorphism characteristics that may have roles in the development of thrombosis in patients with cancer.Methods:  A total of 158 patients with cancer who had had any thrombotic event were included, together with a control group of 134 patients with cancer without a thromboembolic event. The presence of mutations (Factor V Leiden G1691A, prothrombin G20210A) and polymorphisms (methylenetetrahydrofolate reductase [MTHFR] C677T and plasminogen activator inhibitor (PAI‐1) 4G/5G) were analysed.Results:  A heterozygous polymorphism for Factor V Leiden G1691A was found in 48 patients (30.3%) and a homozygous polymorphism in only one (0.63%), compared to 32 heterozygous (23.8%) and one homozygous (0.74%) polymorphism in the control group (P = 0.462). Prothrombin G20210A heterozygous polymorphism was observed in 11(6.9%) and four (2.5%) in the patients and controls, respectively. The MTHFR C677T heterozygous polymorphism was found in 48 (30.3%) and 24 (15.1%) and the homozygous polymorphism was observed in 15 (9.4%) and 12 (7.5%) in the study and control group, respectively (P = 0.04).Conclusion:  Although we found a statistically significant difference between patients with and without thrombosis in respect to MTHFR C677T gene mutation, our data suggest that we do not have enough evidence yet to recommend performing genetic analysis.
Hospital morbidity data for determining spread of disease at diagnosis for colorectal cancer: A validation study
Authors: THOMPSON Bridie , LUMLEY John , COORY Michael 
Published: May 2012

AbstractAims:  There is currently no routine collection of cancer stages in population‐based data in Australia. This study evaluates the accuracy of International classification of diseases (ICD) codes for secondary neoplasms recorded in hospital morbidity data to assign spread of disease at diagnosis for colorectal cancer.Methods:  The reference (gold) standard was the Australian clinicopathological stage (ACPS) documented by a treating colorectal surgeon and derived from histopathology and clinical findings. To allow comparison with stages derived from the hospital morbidity data (HMD), ACPS was mapped to the spread of disease (local, regional and distant). Sensitivity, specificity and positive‐predictive values were calculated to compare the accuracy of stage derived from HMD.Results:  Data from both the reference standard and HMD were available for 499 patients. HMD slightly overestimated patients with local disease (62.3 vs 56.9%). There was a corresponding underestimation of regional and distant spread of disease. While sensitivity for regional and distant disease was moderate (66.4 and 71.4%, respectively), specificity was high (92.7 and 96.6%, respectively).Conclusion:  ICD codes for secondary neoplasms in HMD are limited in their utility for determining the spread of disease for colorectal cancer. Clinicians need to ensure that clinical coders are provided with enough information to accurately code for spread of disease. We recommend reporting histopathology in a synoptic format which includes background information on the presence or absence of distant metastasis and the tumor node metastasis stage.
Prognostic factors for cerebral infraction and outcome in patients with intracranial aneurysm
Authors: Zhu Yuan , Zhao Hongyang , Zhu Xianli 
Published: May 2012

AimThe purpose of this study was to describe prognostic factors for cerebral infraction and outcome in patients undergoing neurosurgical clipping or endovascular coiling with intracranial aneurysms. In addition, we compared the incidence of cerebral infraction and outcome in patients treated with neurosurgical clipping or endovascular coiling.Patients and MethodsData were analysed from 972 patients with intracranial aneurysms enrolled at Union Hospital between September 2007 and May 2011. Multivariable logistic regression with backwards selection were derived to define independent predictors of cerebral infraction and outcome in patients undergoing neurosurgical clipping or endovascular coiling of intracranial aneurysms.ResultsIn the multivariable analysis, cerebral infraction was not associated with the history of hypertension, smoking, diabetes mellitus, aneurysmal size and number, the use of dehydrant and low‐dosage i.v. nimodipine. Factors that contributed most to variation in cerebral infraction, in descending order of importance, were Fisher grade of the computed tomography scan, aneurysmal location, Hunt and Hess scale grade on admission, rupture times, the operating day from first rupture, increasing age, treatment modality and male sex. Predictors of poor outcome, also in descending order of importance, were Hunt and Hess scale grade IV, rupture one to three times, cerebral infraction, Fisher grade 3, operation on 4th−14th day from rupture, diabetes mellitus history, age > 55 years, hypertension history, smoking history and neurosurgical clipping.ConclusionAlthough most prognostic factors for cerebral infraction and outcome after subarachnoid haemorrhage are already present on admission, for suitable patients endovascular coiling and early intervention are recommended.
Novel technique for retroperitoneoscopic nephroureterectomy for patients with huge hydronephrosis
Authors: Nozaki Tetsuo , Iida Akihiro , Morii Akihiro , Fujiuchi Yasuyoshi , Fuse Hideki 
Published: May 2012

IntroductionRetroperitoneal laparoscopic nephroureterectomy (RLNU) presents a therapeutic dilemma for the surgeon, especially in the case of upper urinary tract urothelial carcinoma (UUT‐UC) with huge hydronephrosis (HH). The present study describes a specific technical modification for efficient and successful RLNU for UUT‐UC with HH by using the SAND balloon catheter.Patient and MethodsA 72‐year‐old female underwent RLNU. The SAND balloon catheter was directly inserted into the expanded hydronephrotic kidney, and the liquid was extracted appropriately. Urine leakage from the hydronephrotic kidney was avoided, because the puncture site was sealed firmly between the two adjacent balloons at the tip of the catheter. Disposal counter traction using the catheter facilitated the mobilization of the hydronephrotic kidney.ResultsRLNU with HH was completed without the need for open conversion by the use of the SAND (‘SAND’ derived from ‘sandwich’) balloon catheter. Virtually no spillage occurred during the procedure. The original HH sac could be extracted at its smallest possible size.ConclusionThis method improves the surgeon's vision and facilitates the performance of a resection, without causing any spillage of the hydronephrotic kidney contents during RLNU.
The effect of forest ski‐pistes on butterfly assemblages in the Alps
Authors: ROLANDO ANTONIO , NEGRO MATTEO , D’ENTRÈVES PIETRO P. , BALLETTO EMILIO , PALESTRINI CLAUDIA 
Published: May 2012

Abstract. 1. The abandonment of man‐made pastures below the tree line is favouring natural reforestation in the European Alps. As such, the creation of forest ski‐pistes might, paradoxically, be beneficial to butterflies. This study is the first to focus on the effects of forest ski‐pistes on butterfly assemblages (Lepidoptera, Rhopalocera).2. We sampled both butterflies and flowers on ski‐pistes, in adjacent forests and in the nearest pastures at three sites in the Aosta Valley (north‐western Italian Alps).3. Transect counts showed that butterflies were more abundant on ski‐pistes (and forests) than in pastures. However, species richness and diversity were lower on ski‐pistes than on nearby pastures. Flower abundance was higher, but flower richness and diversity were lower on ski‐pistes than in pastures. Multivariate regression trees indicated that butterfly abundance was positively associated with flower abundance and butterfly diversity was positively associated with flower diversity.4. We conclude that: (i) butterfly abundance on ski‐pistes was higher because in mid‐summer these grassland strips were more abundant in flowers than nearby pastures and (ii) butterfly diversity was lower both because of the lower flower diversity and because of the higher isolation and/or smaller area of ski‐pistes by comparison with pastures.5. In the Alps, several grassland butterfly species are of conservation concern. Ski‐pistes are probably sub‐optimal habitats for butterflies. Nevertheless, within a natural reforestation framework, they may be useful to butterfly conservation, on condition that they are completely re‐vegetated and that grass cover of ski‐pistes are favoured and maintained to facilitate their colonisation.
Proteomics Improves the Prediction of Burns Mortality: Results from Regression Spline Modeling
Authors: Finnerty Celeste C. , Ju Hyunsu , Spratt Heidi , Victor Sundar , Jeschke Marc G. , Hegde Sachin , Bhavnani Suresh K. , Luxon Bruce A. , Brasier Allan R. , Herndon David N. 
Published: May 2012

AbstractPrediction of mortality in severely burned patients remains unreliable. Although clinical covariates and plasma protein abundance have been used with varying degrees of success, the triad of burn size, inhalation injury, and age remains the most reliable predictor. We investigated the effect of combining proteomics variables with these three clinical covariates on prediction of mortality in burned children. Serum samples were collected from 330 burned children (burns covering >25% of the total body surface area) between admission and the time of the first operation for clinical chemistry analyses and proteomic assays of cytokines. Principal component analysis revealed that serum protein abundance and the clinical covariates each provided independent information regarding patient survival. To determine whether combining proteomics with clinical variables improves prediction of patient mortality, we used multivariate adaptive regression splines, because the relationships between analytes and mortality were not linear. Combining these factors increased overall outcome prediction accuracy from 52% to 81% and area under the receiver operating characteristic curve from 0.82 to 0.95. Thus, the predictive accuracy of burns mortality is substantially improved by combining protein abundance information with clinical covariates in a multivariate adaptive regression splines classifier, a model currently being validated in a prospective study. Clin Trans Sci 2012; Volume #: 1–7
Soft and hard clustering methods for delineation of hydrological homogeneous regions in the southern strip of the Caspian Sea Watershed
Authors: Chavoshi S. , Azmin Sulaiman W.N. , Saghafian B. , Sulaiman MD. N.B. , Latifah A.M. 
Published: May 2012

AbstractRegionalisation is a fundamental task for transferring hydrological information from gauged to un‐gauged catchments. This study employs several soft and hard clustering approaches for regionalisation of the 61 catchments located in the southern strip of the Caspian Sea Watershed. Factor analysis using Principal Component Analysis resulted to four out of 16 catchment's attributes relating to flooding which were then used for regionalisation. Hierarchical and Non‐Hierarchical Clustering, K‐Means, Fuzzy C‐Means and Kohonen methods were studied and compared by L‐Moment tests. While in hard clustering approach, distinct clusters of catchments were formed, soft clustering techniques allocated catchments to more than one cluster according to their membership probability. The performance of different clustering methods resulted to the similar number of homogeneous groups. However, the number of sites allocated to the clusters is different. Hard clustering resulted in three clusters at 38, 10 and 13 sites, while Soft clustering allocated 26, 20 and 15 sites to the clusters, respectively. Results indicate a superiority of the soft clustering in the study area where deriving hydrologic groups by hard clustering is problematic.
Anomalous unilateral single pulmonary vein versus scimitar syndrome: Comparison of two paediatric cases and a review of the literature
Authors: Odenthal Cara , Sarikwal Anubhav 
Published: May 2012

SummaryThe ‘scimitar sign’ on plain chest radiograph is most commonly attributed to the presence of a scimitar vein, which is a variant of partial anomalous pulmonary venous drainage (PAPVD). An anomalous unilateral single pulmonary vein (AUSPV) is a very rare anomaly, albeit benign, which can also present with the scimitar sign. Despite a similar radiographic appearance, these two anomalies have very different prognostic implications. Moreover, differentiation between the two is important in the paediatric population to prevent unnecessary investigations. We present two paediatric patients who presented with the scimitar sign on plain chest radiograph, with one having PAPVD and the other having AUSPV, and provide a review of the literature on AUSPV, an anomaly which most likely shares a similar pathogenesis to the scimitar vein of PAPVD.
Effects of Acute and Chronic Atorvastatin on Cardioprotection of Ischemic Postconditioning in Isolated Rat Hearts
Authors: Fan Ying , Yang Shusen , Cao Yang , Huang Yonglin 
Published: May 2012

SummaryBackgroundMyocardial reperfusion therapy remains the most effective strategy to limit infarct size and improve clinical outcome. However, reperfusion injury is still inevitable, and a number of strategies have been developed to ameliorate its lethal outcome. The beneficial roles of ischemic postconditioning (Ipost) have regained more interest in targeting myocardial reperfusion phase to improve cardioprotection.AimsThis study was to determine whether acute or chronic treatment with atorvastatin affects cardioprotection when it was combined with Ipost.ResultsAcute or chronic atorvastatin treatment significantly reduced infarct size and recovered contractile dysfunction during reperfusion. When Ipost was combined with atorvastatin treatment, chronic, but not acute, atorvastatin therapy attenuated the cardioprotective effects of Ipost. Chronic, but not acute, atorvastatin treatment also abolished Ipost‐induced phosphorylation level of Akt and endothelial nitric oxide synthase (eNOS).ConclusionsChronic atorvastatin treatment could interfere with cardioprotective effects of Ipost on limiting infarct size and contractile dysfunction, possibly via inhibition of Akt and eNOS activity. This study suggests that Ipost should be used carefully when atorvastatin is taken by patients with AMI.
On Greenberg’s L-invariant of the symmetric sixth power of an ordinary cusp form
Authors: Harron Robert 
Published: May 2012

AbstractWe derive a formula for Greenberg’s L-invariant of Tate twists of the symmetric sixth power of an ordinary non-CM cuspidal newform of weight ≥4, under some technical assumptions. This requires a ‘sufficiently rich’ Galois deformation of the symmetric cube, which we obtain from the symmetric cube lift to GSp(4)/Q of Ramakrishnan–Shahidi and the Hida theory of this group developed by Tilouine–Urban. The L-invariant is expressed in terms of derivatives of Frobenius eigenvalues varying in the Hida family. Our result suggests that one could compute Greenberg’s L-invariant of all symmetric powers by using appropriate functorial transfers and Hida theory on higher rank groups.
Covers inp-adic analytic geometry and log covers II: cospecialization of the (p′)-tempered fundamental group in higher dimensions
Authors: Lepage Emmanuel 
Published: May 2012

AbstractThe tempered fundamental group of ap-adic variety classifies analytic étale covers that become topological covers for Berkovich topology after pullback by some finite étale cover. This paper constructs cospecialization homomorphisms between the (p′) versions of the tempered fundamental group of the fibers of a smooth morphism with polystable reduction. We study the question for families of curves in another paper. To construct them, we will start by describing the pro-(p′) tempered fundamental group of a smooth and proper variety with polystable reduction in terms of the reduction endowed with its log structure, thus defining tempered fundamental groups for log polystable varieties.