bluuebunny/crossref_metadata_2025_split huggingface dataset:
A combination of PD-1 and TIGIT immune checkpoint inhibitors elicits a strong anti-tumour response in mesothelioma
Authors: Shi Huaikai , Yu Ta-Kun , Johnson Ben , Selvamani Sakthi Priya , Zhuang Ling , Lee Kenneth , Klebe Sonja , Smith Samuel , Wong Kirby , Chen Kate , Clark Georgina , Rath Emma M. , Pearson Holly , Ortega David Gallego , Linton Anthony , Kao Steven , Silveira Pablo , Cheng Yuen Yee 
Published: February 2025

Abstract

Background
Finding effective and curative treatment for mesothelioma remains challenging. While the introduction of immunotherapy combinations using ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1) have offered hope for some patients, a large proportion of mesothelioma cases, particularly the epithelial subtype, have minimal benefit from this.

Methods
Our study was inspired by the results of the AdvanTG-105 phase I clinical trial, which showed partial response with anti-TIGIT/PD-1 treatment in two epithelioid mesothelioma patients. Here, we conducted a comprehensive in vivo experiment involving eight animal treatment groups administered with either PBS (control group), cisplatin/pemetrexed, anti-PD-1, anti-PD-1 + anti-CTLA-4, anti-TIGIT, anti-PD-1 + anti-TIGIT, anti-PD-1 + anti-CTLA-4 + anti-TIGIT, and cisplatin/pemetrexed + anti-PD-1 + anti-TIGIT.

Results
Our results indicate that animals receiving anti-PD-1 + TIGIT exhibited a superior anti-tumour response, with 90% of the treatment group exhibiting an objective response, compared to 60%, 20% and 40% for the standard-of-care anti-PD-1 + CTLA-4, single-agent anti-PD-1 and cisplatin/pemetrexed treatment groups, respectively. Animals receiving anti-PD-1 + TIGIT displayed a significantly reduced average tumour size, with improved weight and survival rates, and fewer adverse effects than those receiving anti-PD-1 + CTLA-4 treatment. Anti-PD-1 + TIGIT-treated animals achieved complete tumour regression, with heightened effector CD8 + T cell and NK cell activity, remaining tumour-free for over 300 days without immune-related adverse events. After initial tumour elimination, anti-PD-1 + TIGIT-treated animals showed no tumour regrowth in the rechallenge experiment.

Conclusion
These findings provide rationale for the development of an anti-PD-1 + TIGIT combination immunotherapy trial for mesothelioma patients.

Graphical Abstract
Top) The comparison of standard-of-care treatment and anti-TIGIT novel combination treatment in the mesothelioma animal models, with an example of response treated with tislelizumab and ociperlimab in a pleural mesothelioma patient in the AdvanTIG-105 study. The number of animals/patients treated and the number of treatment responders are presented. Bottom) Schematic illustration of anti-tumour immune response at the cellular level induced by anti-PD-1/TIGIT checkpoint blockade for efficient cancer immunotherapy.
Fifteen-year trends in diabetes drug management and control in French-speaking Switzerland
Authors: Pauli Ariane , Alkandari Abdullah , Marques-Vidal Pedro 
Published: February 2025

Abstract

Objective
Drug management of type 2 diabetes (T2D) should comply with established guidelines. Still, little is known about how drug management of T2D in Switzerland has evolved over time. We aimed at assessing 15-year trends in antidiabetic drug prescription and its effectiveness in reducing fasting plasma glucose (FPG) levels.

Research design and methods
Data from the baseline (2003–2006) and three follow-ups (2009–2012, 2014–2017 and 2018–2021) of a population-based study conducted in Lausanne, Switzerland. Participants treated for T2D were included. At baseline and the follow-ups, participants had their antidiabetic drugs collected, together with their FPG and glycated haemoglobin (HbA1c) levels.

Results
There were 274, 280, 268 and 195 participants treated for T2D at the baseline, first, second and third follow-ups, respectively, of whom 101 (36.9%), 103 (36.8%), 138 (51.5%) and 84 (43.1%) were controlled (FPG < 7 mmol/L). During the study period, the percentage of biguanides remained stable, the percentage of sulfonylureas and thiazolidinediones decreased, and the percentage of SGLT2 and DPP4 inhibitors increased, but no consistent association with T2D control was found. On bivariate and multivariable analysis, participants with newly diagnosed T2D had a higher likelihood of being controlled than participants with established T2D: odds ratio (95% CI) 3.39 (1.89–6.07), 5.41 (2.25-13.0) and 3.47 (1.45–8.31) for the first, second and third follow-ups on multivariable analysis, respectively.

Conclusions
Despite the prescription of novel antidiabetic drugs, half of participants treated for diabetes do not achieve adequate control in Switzerland. Participants with newly diagnosed diabetes achieve much better control than participants with established diabetes.
Relationship between riparian zones and water quality in the main watersheds of Ushuaia City, Tierra del Fuego (Argentina)
Authors: Granitto María , Lopez María Eugenia , Bursztyn Fuentes Amalia Lara , Maluendez Testoni María Constanza , Rodríguez Patricia 
Published: February 2025

Abstract

Background
Ushuaia City has experienced much population growth and still lacks secondary treatment for its wastewater. As a result, most of the discharge is directed into the lotic ecosystems that cross the urban environment. This paper assesses the relationship between riparian areas and water quality along an urbanization gradient in the city's main watersheds: Pipo River, Buena Esperanza Stream and Arroyo Grande River.

Results
The Riparian Forest Quality Index adapted for Patagonia showed a positive correlation with the Fuegian Water Quality Index (r = 0.83, p < 0.05). Differences in the riparian index along the urban gradient were detected in all the studied watersheds. In general, non-urbanized sites in the upper zones showed very good or good quality while urbanized sites showed worse riparian conditions. Furthermore, in relation to the Fuegian Water Quality Index, this work showed spatial and temporal variations. The Pipo River watershed showed no statistically significant differences among sampling sites, although water quality decreased over time at the urbanized site near the outlet of the river (in March 2018 the Fuegian Water Quality Index was 88 and in March 2022 it was 38). In the Buena Esperanza Stream, significant differences were detected among sampling sites; water quality at the non-urbanized zones in the upper section and upper-middle section was higher than at the urbanized sites. In the Arroyo Grande River, despite the lower ranges of the Fuegian Water Quality Index observed at the urban site near the outlet, no significant differences were identified between study sites.

Conclusion
The relationship of both indices supports the relevance of the environmental surroundings of the watercourses and how their ecological integrity affects water quality in urban lotic ecosystems. The watersheds studied here are strongly linked to the complex dynamics of a growing city which was reflected by the Fuegian Water Quality. Our findings provide a scientific foundation for sustainable environmental management. We recommend integrated water resources management that not only ceases the direct discharge of wastewater into watercourses but also implements measures to protect and restore the riparian environment as a fundamental measure for the conservation of urban lotic ecosystems.
Digital financial inclusion, environmental sustainability and regional economic growth in China: insights from a panel threshold model
Authors: Becha Hamdi , Kalai Maha , Houidi Saifeddine , Helali Kamel 
Published: February 2025

Abstract
As digital technologies rapidly transform global economies, the digital financial inclusion index (DFII) has emerged as a critical driver of economic growth, particularly in developing regions. In the context of China, where regional economic disparities persist, the expansion of digital financial services offers a promising avenue to boost regional development, promote inclusive growth, and enhance environmental sustainability. This study looks into how digital financial inclusion affects regional economic growth (GRP) in China’s provinces. It does this by using a panel threshold autoregressive model (PTAR) and a panel smooth transition autoregressive model (PSTAR) to see if the relationship is not always linear. Drawing on data from 31 Chinese provinces between 2003 and 2022, the analysis uncovers significant threshold effects, revealing distinct phases where digital financial inclusion’s influence on economic growth intensifies as financial inclusion increases. Furthermore, digital financial services empower small and medium-sized enterprises (SMEs) and individual entrepreneurs to invest in eco-friendly innovations and low-emission technologies. By lowering barriers to funding, digital financial inclusion encourages the adoption of cleaner production processes and efficient resource management, which can significantly decrease emissions and improve air quality. Additionally, enhanced financial literacy and access to information through digital platforms enable consumers to make environmentally conscious choices, further contributing to reduced pollution levels. These findings provide empirical evidence of the transformative role of digital finance in both regional development and environmental sustainability, underscoring the need for policy interventions that enhance financial inclusion to drive economic growth.
The social differentiation of depression among Chinese adults: dynamic perspectives and intersectional views
Authors: Qiu Liya , Li Jianxin 
Published: February 2025

Abstract
Based on the hierarchical age–period–cohort cross-classified random effects model, this study utilizes data from the 2010–2020 China Family Panel Studies to analyze the social differentiation of depression among Chinese adults from dynamic and intersectional perspectives. The study reveals that there is a differentiation in depression levels among adults across education, income, and gender that widens with increasing age and over time periods, and exhibits “outliers” and complex fluctuations across birth cohorts. Depression levels in adults differ across the intersecting structures of education and gender, with education demonstrating a more pronounced effect on reducing depression in women, although this effect tends to diminish gradually with increasing age. Over time periods, the gender disparity in depression levels remains stable across different education groups. From a birth cohort perspective, the gender differences in depression levels across various education groups persist in populations born after the mid-1980s.
The “two sessions”: institutional investors selloff to avoid ambiguity
Authors: Wang Jiarui , Yang Haijun , Liu Shancun 
Published: February 2025

Abstract
We construct a model to examine the time-varying ambiguity of investors. When ambiguity occurs concerning recent news, long (short) position investors who are averse to ambiguity reduce (increase) their holdings, resulting in price drops (rises). We empirically analyze how the “two sessions,” a significant event with high policy ambiguity in China, affect the financial market. Our findings suggest that institutional investors mainly sell their holdings between 15 and 5 days before the meetings. Furthermore, the delay in the “two sessions” in 2020 suggests that these selloffs are driven by ambiguity aversion rather than new information.
An immersive virtual reality-based intervention to enhance mobility and patient-reported outcomes in patients with proximal humeral fractures: a case report
Authors: Singh Harpreet , Kashoo Faizan Zaffar , Kumar Chandan 
Published: February 2025

Abstract
Greater tuberosity (GT) fractures of the humerus contribute to 14–20% of all proximal humeral fractures (PHF) and provide considerable challenges because of their proximity to the rotator cuff, which may negatively affect shoulder function if left untreated. A 45-year-old man who had an isolated, non-displaced GT fracture in a motorbike accident is the subject of this case report. The patient received a new virtual reality (VR) intervention and a thorough rehabilitation programme after an initial period of immobility. Through the VR component, the patient was able to participate in immersive exercises designed to improve motivation and movement. Assessments of range of motion and the Constant-Murley Score (CMS), which increased from 16 on day 1 to 33 at the completion of therapy, were used to track progress. Significant gains in shoulder mobility and patient-reported outcomes were observed in the results, indicating that the use of virtual reality could increase the effectiveness of rehabilitation. Further investigation in larger clinical studies is necessary in the context of this example, which supports the potential use of VR as an adjuvant in shoulder rehabilitation following a GT fracture.
Inpatient Immunotherapy Outcomes Study: A Multicenter Retrospective Analysis
Authors: Riaz Fauzia , Vaughn John L. , Zhu Huili , Dickerson James C. , Sayegh Hoda E. , Brongiel Samantha , Baldwin Elena , Kier Melanie W. , Zaemes Jacob , Hearn Caleb , Abdelghany Osama , Cohen Roger B. , Parikh Ravi B. , Reuss Joshua E. , Prsic Elizabeth , Doroshow Deborah B. 
Published: February 2025

PURPOSE
Immune checkpoint inhibitors (ICIs) have revolutionized the care of patients with cancer, but use among hospitalized patients is controversial as a result of questionable benefit and high costs. To evaluate the role of ICIs in the inpatient (IP) setting, we conducted the Inpatient Immunotherapy Outcomes Study (IIOS) to describe characteristics and outcomes of patients who received IP ICIs.

METHODS
IIOS is a retrospective study of patients treated with ICIs during hospitalization between 2012 and 2021 at five academic institutions. Data collection was performed using each institution's electronic medical record. We estimated overall survival (OS) from the first administration of ICI using the Kaplan-Meier method and used adjusted Cox proportional hazards models to explore associations between clinicodemographic variables and OS.

RESULTS
Two hundred fifteen patients received IP ICIs (median age 60 years; 55% White; 14% Black; 13% Hispanic). Thoracic and head and neck (24%), GI (21%), and hematologic (19%) malignancies were most common. Most of the patients were ICI-naïve (75%), had stage IV solid malignancies (75%) at the time of IP ICI initiation, and had no radiographic response to ICI therapy (88%). Median OS from the first IP ICI dose was 1.55 months (95% CI, 1.08 to 1.81) for all patients and 1.28 months (95% CI, 0.95 to 1.80) for patients with advanced solid malignancies. Multivariable Cox proportional hazards model analysis found no clinicodemographic variables associated with improved OS after IP ICI administration.

CONCLUSION
IIOS is the largest multi-institutional effort to describe outcomes after IP ICI administration. Clinical outcomes are poor after IP ICI use and IP ICIs should be used with caution.
A larval zebrafish model of traumatic brain injury: optimizing the dose of neurotrauma for discovery of treatments and aetiology
Authors: Locskai Laszlo F. , Gill Taylor , Tan Samantha A. W. , Burton Alexander H. , Alyenbaawi Hadeel , Burton Edward A. , Allison W. Ted 
Published: February 2025

ABSTRACT
Traumatic brain injuries (TBI) are diverse with heterogeneous injury pathologies, which creates challenges for the clinical treatment and prevention of secondary pathologies such as post-traumatic epilepsy and subsequent dementias. To develop pharmacological strategies that treat TBI and prevent complications, animal models must capture the spectrum of TBI severity to better understand pathophysiological events that occur during and after injury. To address such issues, we improved upon our recent larval zebrafish TBI paradigm emphasizing titrating to different injury levels. We observed coordination between an increase in injury level and clinically relevant injury phenotypes including post-traumatic seizures (PTS) and tau aggregation. This preclinical TBI model is simple to implement, allows dosing of injury levels to model diverse pathologies, and can be scaled to medium- or high-throughput screening.
Conserved roles of ETT and ARF4 in gynoecium development in Brassicaceae with distinct fruit shapes
Authors: McLaughlin Heather Marie , Lü Tian-Feng , Natarajan Bhavani , Østergaard Lars , Dong Yang 
Published: February 2025

ABSTRACT
Gynoecium patterning is dependent on the dynamic distribution of auxin, the signalling of which is transduced through several distinct pathways. ETTIN (ETT)-mediated signalling occurs independently of the canonical auxin pathway, and ETT shares partial redundancy with Auxin Response Factor 4 (ARF4) in the gynoecium. ETT and ARF4 were previously hypothesized to translate auxin gradients into patterns of tissue polarity alongside other ARFs. As ARF repressors, ETT/ARF were assumed to antagonistically regulate targets shared with ARF activators of the canonical pathway. Here, comparative transcriptomics identified the distinct and overlapping targets of ETT/ARF4 in the Arabidopsis gynoecium. However, ETT/ARF4 targets with known roles in gynoecium development did not conform to models of A-B ARF antagonism, leaving the relationship with the canonical pathway unclear. Mutants in tir1 afb2 ett were therefore generated in Arabidopsis and Capsella to assess the relationship between the two pathways, and their conservation in species with distinct fruit shapes. The data presented indicate conserved synergism between the two pathways in gynoecium development and suggest a role for ARF4 in the integration of these pathways in Brassicaceae with distinct fruit shapes.
Adaptation of the Posttraumatic Stress Disorder Checklist for DSM-5
Authors: Valencia Pablo D. , De la Rosa-Gómez Anabel , Barba-Sánchez Alan Ernesto , Hernández-Posadas Alejandrina , Hernandez-Jiménez María Jesús 
Published: February 2025

The PTSD Checklist for DSM-5 (PCL-5) is a recognized instrument for assessing the severity of posttraumatic stress disorder (PTSD) symptoms. Previous studies suggest that the PCL-5 measures a unidimensional construct while capturing the seven specific dimensions of the so-called "hybrid model." While shorter versions of the PCL-5 have been suggested, none have explicitly tested their unidimensionality or covered all seven aspects of the hybrid model. This study employed exploratory and confirmatory methods to develop a brief 7-item version of the PCL-5 involving1,337 individuals seeking psychological support in Mexico. The sample was randomly distributed, using the first half to create the new short version and the second to test this and other previously proposed versions. This 7-item version and Price et al.'s (2014) 4-item version demonstrated satisfactory fit, and the one used in the present research, showing higher reliability (ω = .83) compared to Price et al.'s (ω = .73). Both versions demonstrated consistent performance across sexes. The adaptation of the scale presented here displayed stronger correlations with depression, anxiety, and worry. More closely resembling those of the longer PCL-5, in contrast to Price et al.'s version. The short PCL-5 may prove useful for measuring PTSD symptoms in situations where administering the lengthier PCL-5 is impractical. Future investigations should explore the performance of these short versions across different populations.
Source Theory: A Tractable and Positive Ambiguity Theory
Authors: Baillon Aurélien , Bleichrodt Han , Li Chen , Wakker Peter P. 
Published: February 2025

This paper introduces source theory, a new theory for decision under ambiguity (unknown probabilities). It shows how Savage’s subjective probabilities, with source-dependent nonlinear weighting functions, can model Ellsberg’s ambiguity. It can do so in Savage’s framework of state-contingent assets, permits nonexpected utility for risk, and avoids multistage complications. It is tractable, shows ambiguity attitudes through simple graphs, is empirically realistic, and can be used prescriptively. We provide a new tool to analyze weighting functions: pmatchers. They give Arrow–Pratt-like transformations but operate “within” rather than “outside” functions. We further show that ambiguity perception and inverse S probability weighting, seemingly unrelated concepts, are two sides of the same “insensitivity” coin. This paper was accepted by Manel Baucells, behavioral economics and decision analysis. Funding: H. Bleichrodt acknowledges financial support from the Spanish Ministry of Science, Innovation and Universities [Project PID2022-142356NB-I00 financed by Grant MICIU/AEI/10.13039/501100011033 and by FEDER] and from the Consellería de Innovación Universidades, Ciencia y Sociedad Digital de la Generalitat Valenciana [Grant Prometeo/2021/073]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.03307 .
Dowry-Related Aggression and Mental Health Concomitants among Educated Women in Pakistan
Authors: Khan Taalia , Ã–sterman Karin , BjÃ¶rkqvist Kaj 
Published: February 2025

AbstractÂ The aim of the study was to investigate victimization from dowry-related aggression and mental health concomitants in a sample of educated women in Pakistan. A questionnaire was completed by 569 women. The mean age was 31.4 years (SD 9.1). The questionnaire included two scales for measuring dowry-related aggression and four scales for measuring mental health concomitants. Â The levels of victimization from dowry-related aggression were relatively low in the sample. Aggression carried out by the husband and the mother-in-law correlated highly with each other. The most common single act by both husbands and mothers-in-law was forcing the wife to give her gold to her mother-in-law or sister-in-law. Women who were more than average victimised from dowry-related aggression had significantly higher scores on anxiety, depression, obsessive-compulsive symptoms, and somatisation. Aggression carried out by the mother-in-law showed higher predictive power on all four mental health concomitants than aggression by the husband. Somatic symptoms of the daughter-in-law showed the highest association with aggression carried out by the mother-in-law. Victimization from dowry-related aggression was strongly associated with negative mental health outcomes. Aggression carried out by the mother-in-law was more strongly associated with them than aggression carried out by the husband.
High-peak-power nanosecond pulsed red laser at 657 nm based on the Nd:YLF dual-crystal scheme
Authors: Zhao Hui , Dai Shibo , Wang Yisen , Li Keyin , Li Yongyao , Li Zhen , Chen Zhenqiang 
Published: February 2025

We demonstrated a high-peak-power nanosecond pulsed Nd:YLF dual-crystal-based red laser by intracavity frequency-doubling with a type-I critical phase-matched BIBO crystal. With the aid of the elaborately designed L-shaped resonator and the linearly polarized pump, excellent mode matching and high pump absorption efficiency have been substantiated. Under the incident pump power of 82.7 W, laser emission at 657 nm was realized with the maximum output power of 6.3 W at a repetition rate of 4 kHz. And the average beam quality factor was detected to be M2 = 1.68. The pulse energy was scaled up to 3.45 mJ at the repetition rate of 1 kHz, corresponding to a pulse duration of 45 ns and a peak power of up to 77 kW. Additionally, the wavelength could be tuned from 656.3 nm to 657.1 nm after inserting an etalon, with the spectral linewidth all less than 0.05 nm.