bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloaking via change of variables for the Helmholtz equation in the whole space
Authors: Nguyen Hoai‐Minh 
Published: June 2010

AbstractThis paper is devoted to the study of a cloaking device that is composed of a standard near cloak based on a regularization of the transformation optics, i.e., a change of variables that blows up a small ball to the cloaked region, and a fixed lossy layer for the Helmholtz equation in the whole space of dimension 2 or 3 with the outgoing condition at infinity. We establish a degree of near invisibility, which is independent of the content inside the cloaked region, for this device. We also show that the lossy layer is necessary to ensure the validity of the degree of near invisibility when no constraint on physical properties inside the cloaked region is imposed. © 2010 Wiley Periodicals, Inc.
A secure and efficient data aggregation scheme for wireless sensor networks
Authors: Zhu Wen Tao , Gao Fei , Xiang Yang 
Published: June 2010

AbstractIn resource‐constrained wireless sensor networks, data aggregation is a key technique for power‐efficient information acquisition. Consequently, the intermediate sensor nodes performing aggregation tasks known as aggregators are valuable and attractive targets for attackers. We address the problem of defending against malicious adversaries who intend to stealthily change some aggregates to entice the base station to accept deceiving results. A secure and efficient aggregation scheme is proposed, in which the base station composes a secret configuration matrix and each sensor node is pre‐loaded with a limited part of the matrix known as a secret share containing certain local instructions. For each aggregation session, a set of scrambled aggregates are constructed in such a manner that there exists a secret yet unrevealed relationship between these values. The base station, aware of the relationship derived from the configuration matrix, can both extract the intended result from the received aggregates and verify it on its own. Our scheme avoids the interactive verification phase which existent protocols typically take to ensure the aggregation integrity, and thus observably lowers the communication overhead. The proposed scheme also features protection of data confidentiality, and analysis shows that it can detect stealthy alteration attacks with a significant probability. Copyright © 2010 John Wiley & Sons, Ltd.
Crystal growth by the travelling heater method using tapered crucibles and applied rotating magnetic field
Authors: Roszmann J. , Dost S. , Lent B. 
Published: June 2010

AbstractCrystal growth experiments were carried out by the Travelling Heater Method using tapered growth ampoules with and without the application of a rotating magnetic field. The objective was to enhance its commercial potential by reducing the size of required seed crystals and increasing the growth rate. To this end, a number of GaSb crystals were grown using either 25 mm diameter straight, or 10 mm to 25 mm tapered growth ampoules. Growth rates of 2 mm/day and 5 mm/day were employed. The effect of rotating magnetic fields of several strengths and frequencies was examined. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
CD5‐positive chronic B‐cell lymphoproliferative disorders: Diagnosis and prognosis of a heterogeneous disease entity
Authors: Dronca Roxana S. , Jevremovic Dragan , Hanson Curtis A. , Rabe Kari G. , Shanafelt Tait D. , Morice William G. , Call Timothy G. , Kay Neil E. , Collins Charles S. , Schwager Susan M. , Slager Susan L. , Zent Clive S. 
Published: June 2010

AbstractBackground:The pathology and clinical course of patients with CD5+ chronic B‐cell lymphoproliferative disorders, excluding those that present with typical chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) or mantle cell lymphoma, (i.e. CD5+B‐CLPD) are poorly defined.Methods:We studied patients with CD5+B‐CLPD to (1) more completely define the clinical features and pathology of CD5+B‐CLPD, (2) compare these features to patients presenting with typical CLL, and (3) test the hypothesis that a subset of patients with CD5+B‐CLPD could have a unique B‐cell malignancy.Results:We identified 229 patients with CD5+B‐CLPD. A definitive pathological diagnosis was made in all 61 (27%) CD5+B‐CLPD patients with nonbone marrow (BM) biopsy specimens considered adequate for a comprehensive pathological examination. The most common diagnosis among these 61 patients was CLL (44%) followed by the leukemic phase of marginal zone lymphoma (34%), lymphoplasmacytic lymphoma (11%), diffuse large B cell lymphoma (8%), and high‐grade B cell lymphoma not otherwise specified (2%). In contrast, among 168 patients without a non‐BM tissue biopsy specimen, a specific diagnosis could be made on review of all available data in only 24 (14%) with 144 (86%) remaining “unclassified.”Conclusions:In patients with CD5+B‐CLPD, a definitive diagnosis can be made on an adequate non‐BM tissue biopsy suggesting that this entity does not include a novel disease. We recommend that all patients with CD5+B‐CLPD should have a non‐BM tissue biopsy to make a definitive diagnosis prior to initiation of treatment. © 2010 International Clinical Cytometry Society
Toward an understanding of the role of notochordal cells in the adult intervertebral disc: From discord to accord
Authors: Risbud Makarand V. , Schaer Thomas P. , Shapiro Irving M. 
Published: June 2010

AbstractThe goal of this mini‐review is to address the long standing argument that the pathogenesis of disc disease is due to the loss and/or the replacement of the notochordal cells by other cell types. We contend that, although cells of different size and morphology exist, there is no strong evidence to support the view that the nucleus pulposus contains cells of distinct lineages. Based on lineage mapping studies and studies of other notochordal markers, we hypothesize that in all animals, including human, nucleus pulposus retains notochordal cells throughout life. Moreover, all cells including chondrocyte‐like cells are derived from notochordal precursors, and variations in morphology and size are representative of different stages of maturation, and or, function. Thus, the most critical choice for a suitable animal model should relate more to the anatomical and mechanical characteristics of the motion segment than concerns of cell loss and replacement by non‐notochordal cells. Developmental Dynamics 239:2141–2148, 2010. © 2010 Wiley‐Liss, Inc.
Appl1 is essential for the survival of Xenopus pancreas, duodenum, and stomach progenitor cells
Authors: Wen Luan , Yang Yong , Wang Yu , Xu Aimin , Wu Donghai , Chen Yonglong 
Published: June 2010

AbstractAn understanding of the molecular mechanisms governing the survival of organ progenitor cells in vivo is crucial for in vitro tissue regeneration. Here, we have found that Xenopus appl1 and akt2 share a similar embryonic expression pattern, showing characteristic expression in the central nervous system as well as in the pancreas and part of the stomach/duodenum (SD) at tadpole stages of development. Specific knockdown of appl1 in endoderm or inhibition of akt activity did not affect the formation of endodermal organ primordia at tail bud stages of development, but led to a gut‐coiling defect, strong apoptosis in endodermal organs, and pancreas and SD hypoplasia or even aplasia at tadpole stages of development. Furthermore, appl1 is required for akt phosphorylation and akt2 in turn can rescue appl1 knockdown phenotypes. Together, our data suggest that appl1‐akt signaling is specifically required for the survival of pancreas and SD progenitor cells in Xenopus laevis embryos. Developmental Dynamics 239:2198–2207, 2010. © 2010 Wiley‐Liss, Inc.
Electric transfer function model of switched reluctance motors and model‐based current control design
Authors: Ishikawa Hiroki , Komaki Ryoko , Naitoh Haruo , Yamaba Akira , Katoh Hiroki 
Published: June 2010

AbstractThis paper presents a current control design for switched reluctance motors (SRMs). The electric transfer characteristic of the motors is studied first. Their transfer function is shown to be expressible by a pure resistive component, which is not constant but varies depending on the motor current and speed. The current control design for SRMs follows the classical design technique used for DC machines, where the zeros of the PI controller cancel the poles of Ls+R. Because the transfer function of SRMs does not have any poles, an I controller is suitable for them. The integral gain should be adjusted in order to compensate the nonlinearity, that is, the variation in the equivalent resistor of the SRMs' transfer function. The values of the integral gain are tuned and tabulated for the motor speed and current. Simulation and experiment demonstrate that the current and speed of the SRMs present good responses without dependence on the motor speed and current. © 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(1): 51–59, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20987
Influence of Ionic Strength on Electrochemical Responses of Myoglobin Loaded in Polysaccharide Layer‐by‐Layer Assembly Films
Authors: Liu Yan , Liu Hongyun , Guo Xihong , Hu Naifei 
Published: June 2010

AbstractTwo polysaccharides hydroxyethyl cellulose ethoxylate (HECE) and hyaluronic acid (HA) were assembled into {HECE/HA}n layer‐by‐layer films on electrodes. The films were then immersed in myoglobin (Mb) solutions to load Mb into the films. The Mb‐loaded films showed a nearly reversible cyclic voltammetric (CV) peak pair at −0.34 V vs. SCE in pH 7.0 buffers. The effect of ionic strength in Mb loading solutions and CV testing solutions on the CV response of the films was investigated. The direct electrochemistry of Mb loaded in the films could also be used to electrocatalyze the reduction of oxygen and H2O2 in solution.
Influence of fermentation metabolites on redox potential in anaerobic digestion of proteinaceous solid wastes by Synergistes sp.
Authors: Kumar Arumugam Ganesh , Kirubagaran Ramalingam , Nagesh Narayana , Parrado Rubio Juan , Sekaran Ganesan 
Published: June 2010

AbstractThe anaerobic digestion of animal fleshing from tannery solid waste was investigated with regard to hydrolytic enzymes, protease and lipase, fermentative enzyme deaminase, soluble protein and amino acids, redox potential (Eh), volatile fatty acids, ammonia and carbon dioxide up to 120 h of retention time. The release of these fermentation metabolites at various retention times greatly influenced the Eh. In the hydrolytic phase, the maximum value of Eh was −50 mV and it reached the minimum of −350 mV in 24 h in the fermentative phase. The minimum and maximum values of Eh were −387 and −452 mV at 80 h of anaerobic digestion. The release of extracellular metabolites was confirmed by HPLC and GC‐MS. In this study, we have found that the ammonia and pH had a substantial influence on the Eh during the anaerobic digestion of animal fleshing.
Term Structure Forecasting: No‐Arbitrage Restrictions versus Large Information Set
Authors: Favero Carlo A. , Niu Linlin , Sala Luca 
Published: June 2010

ABSTRACTThis paper addresses the issue of forecasting term structure. We provide a unified state‐space modeling framework that encompasses different existing discrete‐time yield curve models. Within such a framework we analyze the impact of two modeling choices, namely the imposition of no‐arbitrage restrictions and the size of the information set used to extract factors, on forecasting performance. Using US yield curve data, we find that both no‐arbitrage and large information sets help in forecasting but no model uniformly dominates the other. No‐arbitrage models are more useful at shorter horizons for shorter maturities. Large information sets are more useful at longer horizons and longer maturities. We also find evidence for a significant feedback from yield curve models to macroeconomic variables that could be exploited for macroeconomic forecasting. Copyright © 2010 John Wiley & Sons, Ltd.
Detection of SNP‐SNP interactions in trios of parents with schizophrenic children
Authors: Li Qing , Fallin M. Daniele , Louis Thomas A. , Lasseter Virginia K. , McGrath John A. , Avramopoulos Dimitri , Wolyniec Paula S. , Valle David , Liang Kung‐Yee , Pulver Ann E. , Ruczinski Ingo 
Published: June 2010

AbstractSchizophrenia (SZ) is a heritable and complex psychiatric disorder with an estimated worldwide prevalence of about 1%. Research on the risk factors for SZ has thus far yielded few clues to causes, but has pointed to a heterogeneous etiology that likely involves multiple genes and gene‐environment interactions. In this manuscript, we apply a novel method (trio logic regression, Li et al., 2009) to case‐parent trio data from a SZ candidate gene study conducted on families of Ashkenazi Jewish descent, and demonstrate the method's ability to detect multi‐gene models for SZ risk in the family‐based design. In particular, we demonstrate how this method revealed a genotype‐phenotype association that includes an allele without marginal effect. Genet. Epidemiol. 34: 396–406, 2010. © 2010 Wiley‐Liss, Inc.
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
Authors: Ferlay Jacques , Shin Hai‐Rim , Bray Freddie , Forman David , Mathers Colin , Parkin Donald Maxwell 
Published: June 2010

AbstractEstimates of the worldwide incidence and mortality from 27 cancers in 2008 have been prepared for 182 countries as part of the GLOBOCAN series published by the International Agency for Research on Cancer. In this article, we present the results for 20 world regions, summarizing the global patterns for the eight most common cancers. Overall, an estimated 12.7 million new cancer cases and 7.6 million cancer deaths occur in 2008, with 56% of new cancer cases and 63% of the cancer deaths occurring in the less developed regions of the world. The most commonly diagnosed cancers worldwide are lung (1.61 million, 12.7% of the total), breast (1.38 million, 10.9%) and colorectal cancers (1.23 million, 9.7%). The most common causes of cancer death are lung cancer (1.38 million, 18.2% of the total), stomach cancer (738,000 deaths, 9.7%) and liver cancer (696,000 deaths, 9.2%). Cancer is neither rare anywhere in the world, nor mainly confined to high‐resource countries. Striking differences in the patterns of cancer from region to region are observed.
Metabolic syndrome and risk of bladder cancer: prospective cohort study in the metabolic syndrome and cancer project (Me‐Can)
Authors: Häggström Christel , Stocks Tanja , Rapp Kilian , Bjørge Tone , Lindkvist Björn , Concin Hans , Engeland Anders , Manjer Jonas , Ulmer Hanno , Selmer Randi , Tretli Steinar , Hallmans Göran , Jonsson Håkan , Stattin Pär 
Published: June 2010

AbstractThere are little data on the putative association between factors in the metabolic syndrome (MetS) and risk of bladder cancer. In the Metabolic Syndrome and Cancer project (Me‐Can), measurements of height, weight, blood pressure and circulating levels of glucose, cholesterol, and triglycerides had been collected from 578,700 subjects in cohorts in Norway, Austria, and Sweden. We used Cox proportional hazard models to calculate relative risks (RRs) of bladder cancer by exposures divided into quintiles, in categories according to the World Health Organisation (WHO) and as a continuous standardized variable (z‐score with mean = 0 and standard deviation = 1) for each separate component and its standardized sum, a composite MetS score. RRs were corrected for random error in measurements. During a mean follow‐up of 11.7 years (SD = 7.6), 1,587 men and 327 women were diagnosed with bladder cancer. Significant associations with risk were found among men per one unit increment of z‐score for blood pressure, RR = 1.13 (95% CI 1.03–1.25), and the composite MetS score, RR = 1.10 (95% CI 1.01–1.18). Among women, glucose was nonsignificantly associated with risk, RR = 1.41 (95% CI 0.97–2.06). No statistically significant interactions were found between the components in the MetS in relation to bladder cancer risk. Hypertension and a composite MetS score were significantly but modestly associated with an increased risk of bladder cancer among men and elevated glucose was associated with a nonsignificant increase in risk among women.
Genetic variation in the TNFRSF11A gene encoding RANK is associated with susceptibility to Paget's disease of bone
Authors: Chung Pui Yan Jenny , Beyens Greet , Riches Philip L , Van Wesenbeeck Liesbeth , de Freitas Fenna , Jennes Karen , Daroszewska Anna , Fransen Erik , Boonen Steven , Geusens Piet , Vanhoenacker Filip , Verbruggen Leon , Van Offel Jan , Goemaere Stefan , Zmierczak Hans-Georg , Westhovens René , Karperien Marcel , Papapoulos Socrates , Ralston Stuart H , Devogelaer Jean-Pierre , Van Hul Wim 
Published: June 2010

Abstract
RANK (receptor activator of nuclear factor-κB), encoded by TNFRSF11A, is a key protein in osteoclastogenesis. TNFRSF11A mutations cause Paget's disease of bone (PDB)–like diseases (ie, familial expansile osteolysis, expansile skeletal hyperphosphatasia, and early-onset PDB) and an osteoclast-poor form of osteopetrosis. However, no TNFRSF11A mutations have been found in classic PDB, neither in familial nor in isolated cases. To investigate the possible relationship between TNFRSF11A polymorphisms and sporadic PDB, we conducted an association study including 32 single-nucleotide polymorphisms (SNPs) in 196 Belgian sporadic PDB patients and 212 control individuals. Thirteen SNPs and 3 multimarker tests (MMTs) turned out to have a p value of between .036 and 3.17 × 10−4, with the major effect coming from females. Moreover, 6 SNPs and 1 MMT withstood the Bonferroni correction (p &lt; .002). Replication studies were performed for 2 nonsynonymous SNPs (rs35211496 and rs1805034) in a Dutch and a British cohort. Interestingly, both SNPs resulted in p values ranging from .013 to 8.38 × 10−5 in both populations. Meta-analysis over three populations resulted in p = .002 for rs35211496 and p = 1.27 × 10−8 for rs1805034, again mainly coming from the female subgroups. In an attempt to identify the underlying causative SNP, we performed functional studies for the coding SNPs as well as resequencing efforts of a 31-kb region harboring a risk haplotype within the Belgian females. However, neither approach resulted in significant evidence for the causality of any of the tested genetic variants. Therefore, further studies are needed to identify the real cause of the increased risk to develop PDB shown to be present within TNFRSF11A. © 2010 American Society for Bone and Mineral Research.
Simvastatin induces osteogenic differentiation of murine embryonic stem cells
Authors: Pagkalos Joseph , Cha Jae Min , Kang Yunyi , Heliotis Manolis , Tsiridis Eleftherios , Mantalaris Athanasios 
Published: June 2010

Abstract
Statins are potent inhibitors of cholesterol synthesis. Several statins are available with different molecular and pharmacokinetic properties. Simvastatin is more lipophilic than pravastatin and has a higher affinity to phospholipid membranes than atorvastatin, allowing its passive diffusion through the cell membrane. In vitro studies on bone marrow stromal cells, osteoblast-like cells, and embryonic stem cells have shown statins to have cholesterol-independent anabolic effects on bone metabolism; alas, statins were supplemented in osteogenic medium, which does not facilitate elucidation of their potential osteoinductive properties. Embryonic stem cells (ESCs), derived from the inner cell mass of the blastocyst, are unique in that they enjoy perpetual self-proliferation, are pluripotent, and are able to differentiate toward all the cellular lineages composing the body, including the osteogenic lineage. Consequently, ESCs represent a potentially potent cell source for future clinical cellular therapies of various bone diseases, even though there are several hurdles that still need to be overcome. Herein we demonstrate, for the first time to our knowledge, that simvastatin induces murine ESC (mESC) differentiation toward the osteogenic lineage in the absence of osteoinductive supplements. Specifically, we found that a simvastatin concentration in the micromolar range and higher was toxic to the cells and that an effective concentration for osteoinduction is 0.1 nM, as shown by increased alizarin red staining as well as increased osteocalcin and osetrix gene expression. These results suggest that in the future, lipophilic simvastatin may provide a novel pharmacologic agent for bone tissue engineering applications. © 2010 American Society for Bone and Mineral Research.
Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing
Authors: Kwon Oh Yeun , Hwang Kyounghee , Kim Jeom‐A , Kim Kwangmyung , Kwon Ick Chan , Song Hyun Kyu , Jeon Hyesung 
Published: June 2010

AbstractFe65 and Dab1 are adaptor proteins that interact with the cytoplasmic domain of amyloid precursor protein (APP) via phosphotyrosine‐binding (PTB) domain and that affect APP processing and Aβ production. Co‐expression of Dab1 with Fe65 and APP resumed nuclear translocation of Fe65 despite of its cytoplasmic anchor, APP. The decreased amount of Fe65 bound to APP was shown in co‐immunoprecipitation assay from the cells with Dab1 which also displayed the effect on APP processing. These data suggested that Fe65 and Dab1 compete for binding to APP. Surprisingly, we found that Fe65 interacts with Dab1 via C‐terminal region of Dab1 and unphosphorylated Dab1 is capable of binding Fe65. Dab1 interacts with the low‐density lipoprotein receptor‐related protein (LRP) as well as APP through its PTB domain. Dab1 significantly decreased the amount of APP bound to LRP and the level of secreted APP and APP‐CTF in LRP expressing cells, unlike Fe65. It implies that overexpression of Dab1 diminish LRP–APP complex formation, resulting in altered APP processing. The competition for overlapped binding site among adaptor proteins may be related to the regulation mechanism of APP metabolism in various conditions. J. Cell. Biochem. 111: 508–519, 2010. © 2010 Wiley‐Liss, Inc.
Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairment
Authors: Erikstein Bjarte S. , Hagland Hanne R. , Nikolaisen Julie , Kulawiec Mariola , Singh Keshav K. , Gjertsen Bjørn T. , Tronstad Karl J. 
Published: June 2010

AbstractMitochondrial bioenergetics and reactive oxygen species (ROS) often play important roles in cellular stress mechanisms. In this study we investigated how these factors are involved in the stress response triggered by resazurin (Alamar Blue) in cultured cancer cells. Resazurin is a redox reactive compound widely used as reporter agent in assays of cell biology (e.g. cell viability and metabolic activity) due to its colorimetric and fluorimetric properties. In order to investigate resazurin‐induced stress mechanisms we employed cells affording different metabolic and regulatory phenotypes. In HL‐60 and Jurkat leukemia cells resazurin caused mitochondrial disintegration, respiratory dysfunction, reduced proliferation, and cell death. These effects were preceded by a burst of ROS, especially in HL‐60 cells which were also more sensitive and contained autophagic vesicles. Studies in Rho0 cells (devoid of mitochondrial DNA) indicated that the stress response does not depend on the rates of mitochondrial respiration. The anti‐proliferative effect of resazurin was confirmed in native acute myelogenous leukemia (AML) blasts. In conclusion, the data suggest that resazurin triggers cellular ROS production and thereby initiates a stress response leading to mitochondrial dysfunction, reduced proliferation, autophagy, and cell degradation. The ability of cells to tolerate this type of stress may be important in toxicity and chemoresistance. J. Cell. Biochem. 111: 574–584, 2010. © 2010 Wiley‐Liss, Inc.