bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification and validation of a costimulatory molecule-related signature to predict the prognosis for uveal melanoma patients
Authors: Zhao Minyao , Yu Yue , Song Zhengyu 
Published: April 2024

AbstractUveal melanoma (UVM) is the most common primary tumor in adult human eyes. Costimulatory molecules (CMs) are important in maintaining T cell biological functions and regulating immune responses. To investigate the role of CMs in UVM and exploit prognostic signature by bioinformatics analysis. This study aimed to identify and validate a CMs associated signature and investigate its role in the progression and prognosis of UVM. The expression profile data of training cohort and validation cohort were downloaded from The Cancer Genome Atlas (TCGA) dataset and the Gene Expression Omnibus (GEO) dataset. 60 CM genes were identified, and 34 genes were associated with prognosis by univariate Cox regression. A prognostic signature was established with six CM genes. Further, high- and low-risk groups were divided by the median, and Kaplan–Meier (K-M) curves indicated that high-risk patients presented a poorer prognosis. We analyzed the correlation of gender, age, stage, and risk score on prognosis by univariate and multivariate regression analysis. We found that risk score was the only risk factor for prognosis. Through the integration of the tumor immune microenvironment (TIME), it was found that the high-risk group presented more immune cell infiltration and expression of immune checkpoints and obtained higher immune scores. Enrichment analysis of the biological functions of the two groups revealed that the differential parts were mainly related to cell–cell adhesion, regulation of T-cell activation, and cytokine–cytokine receptor interaction. No differences in tumor mutation burden (TMB) were found between the two groups. GNA11 and BAP1 have higher mutation frequencies in high-risk patients. Finally, based on the Genomics of Drug Sensitivity in Cancer 2 (GDSC2) dataset, drug sensitivity analysis found that high-risk patients may be potential beneficiaries of the treatment of crizotinib or temozolomide. Taken together, our CM-related prognostic signature is a reliable biomarker that may provide ideas for future treatments for the disease.
Bidirectional association between falls and multimorbidity in middle-aged and elderly Chinese adults: a national longitudinal study
Authors: Tian Ye , Zhou Xingzhao , Jiang Yan , Pan Yidan , Liu Xuefeidan , Gu Xingbo 
Published: April 2024

AbstractThis study explores the bidirectional association between multimorbidity and falls in Chinese middle-aged and elderly adults. Participants aged 45 and above from the China Health and Retirement Longitudinal Study were included. Binary logistic regression assessed the impact of chronic conditions on fall incidence (stage I), while multinomial logistic regression examined the relationship between baseline falls and multimorbidity (stage II). The fully adjusted odds ratios (ORs) for one, two, or three or more chronic conditions were 1.34, 1.65, and 2.02, respectively. Among participants without baseline falls, 28.61% developed two or more chronic conditions during follow-up, compared to 37.4% of those with a history of falls. Fully adjusted ORs for one, two, or three or more chronic conditions in those with a history of falls were 1.21, 1.38 and 1.70, respectively. The bidirectional relationship held in sensitivity and subgroup analyses. A bidirectional relationship exists between multimorbidity and falls in Chinese middle-aged and elderly adults. Strengthening chronic condition screening and treatment in primary healthcare may reduce falls risk, and prioritizing fall prevention and intervention in daily life is recommended.
The synergistic effect of dielectric barrier discharge plasma and phycocyanin on shelf life of Oncorhynchus mykiss rainbow fillets
Authors: Seyedalangi Maedehsadat , Sari Amir Hossein , Nowruzi Bahareh , Anvar Seyed Amir Ali 
Published: April 2024

AbstractThis study aimed to evaluate the efficacy of dielectric barrier discharge treatment (DBD) combined with phycocyanin pigment (PC) in extending the shelf life of Oncorhynchus mykiss rainbow fillets stored at 4 ± 0.1 °C. Microbiological, physicochemical, sensory and antioxidant properties were assessed over an 18-day storage period. The combined DBD and PC treatment significantly inhibited total viable counts and Psychrotrophic bacteria counts compared to the rest of the samples throughout storage. While Total Volatile Nitrogen concentrations remained below international standard until day 18, they exceeded this threshold in control sample by day 9. DBD treatment notably reduced Trimethylamine levels compared to controls (p < 0.05). PC and DBD combined inhibited DPPH and ABTS radical scavenging capacities by 80% and 85%, respectively, while demonstrating heightened iron-reducing antioxidant activity compared to controls. Analysis of 24 fatty acids indicated that PC mitigated DBD’s adverse effects, yielding superior outcomes compared to controls. The ratio of n-3 to n-6 fatty acids in all samples met or fell below international standard. Thus, the combined use of DBD and PC shows promise in extending fillet shelf life by over 15 days at 4 °C.
Complex networks approach to study comorbidities in patients with unruptured intracranial aneurysms
Authors: Kivelev Juri , Saarenpää Ilkka , Karlsson Antti , Crisafulli Paride , Musciotto Federico , Piilo Jyrki , Mantegna Rosario N. 
Published: April 2024

AbstractThe role of complex network analysis in patients with diagnosis of unruptured intracranial aneurysm is unexplored. The objective of this study is to assess the applicability of this methodology in aneurysm patients. We retrospectively analyze comprehensive unbiased local digital data of a large number of patients treated for any reason between January 2004 and July 2019. We apply an age-cohort approach to a total of 628,831 patients and construct the diagnostic history of each patient—and include the information how old the patient was when diagnosed for the first time with each diagnosis coded according to International Classification of Diseases. For each cohort of age within a 10 year interval and for each gender, we construct a statistically validated comorbidity network and focused on crucial comorbidity links that the aneurysm code has to other disease codes within the whole network. For all cohorts of different age and gender, the analysis shows that 267 diagnose codes have nearest neighbour statistically validated links to unruptured aneurysm ICD code. Among the 267 comorbidities, 204 (76%) were found in patients aged from 40 to 69-years old. Patterns of connectivity with aneurysms were found for smoking, hypertension, chronic obstructive pulmonary disease, dyslipidemia, and mood disorders. A few uncommon connections are also detected in cohorts of female patients. Our study explored the applicability of network analysis and statistical validation in aneurysm observational study.
Efficacy of interstitial photodynamic therapy using talaporfin sodium and a semiconductor laser for a mouse allograft glioma model
Authors: Nagai Kenta , Akimoto Jiro , Fukami Shinjiro , Saito Yuki , Ogawa Emiyu , Takanashi Masakatsu , Kuroda Masahiko , Kohno Michihiro 
Published: April 2024

AbstractTo investigate the therapeutic potential of photodynamic therapy (PDT) for malignant gliomas arising in unresectable sites, we investigated the effect of tumor tissue damage by interstitial PDT (i-PDT) using talaporfin sodium (TPS) in a mouse glioma model in which C6 glioma cells were implanted subcutaneously. A kinetic study of TPS demonstrated that a dose of 10 mg/kg and 90 min after administration was appropriate dose and timing for i-PDT. Performing i-PDT using a small-diameter plastic optical fiber demonstrated that an irradiation energy density of 100 J/cm2 or higher was required to achieve therapeutic effects over the entire tumor tissue. The tissue damage induced apoptosis in the area close to the light source, whereas vascular effects, such as fibrin thrombus formation occurred in the area slightly distant from the light source. Furthermore, when irradiating at the same energy density, irradiation at a lower power density for a longer period of time was more effective than irradiation at a higher power density for a shorter time. When performing i-PDT, it is important to consider the rate of delivery of the irradiation light into the tumor tissue and to set irradiation conditions that achieve an optimal balance between cytotoxic and vascular effects.
Techno‐economic assessment of distribution system considering different types of electric vehicles and distributed generators
Authors: Babu R G Sarvesh , Reddy K Mithra Vinda , S Shwetha , GS Sivasankari , K Narayanan , Sharma Anurag , Tellez Alexander Aguila 
Published: April 2024

AbstractThe global warming crisis, together with environmental concerns, has already led governments to replace traditional fossil‐fuel cars with low‐emission Electric Vehicles (EVs). This replacement has resulted in the addition of a large number of EVs capable of connecting to the grid. A coordinated charging method is needed to promote EVs on a large scale while preventing grid overloading. In this work, EVs are categorized based on their battery capacity, as cars, trucks, and buses. A charging/discharging mechanism based on Real Time Pricing for each hour is developed for a 20‐min block that has been formed. The locations of EV charging stations have been identified using Voltage Stability Index.In the present work, the power loss when Distributed Generator (DG) units are deployed after the EVs are located in the system for charging and discharging is analyzed. The DGs are considered as solar‐based or wind‐based generators for studying the economic benefit of such an investment under two different weather scenarios and topologies on standard test systems. The results thus obtained give an insight into the various technical and economic benefits.
Unsupervised hyperspectral images classification using hypergraph convolutional extreme learning machines
Authors: Zhang Hongrui , Lv Hongfei , Wang Mengke , Wang Luyao , Xu Jinhuan , Wang Fenggui , Li Xiangdong 
Published: April 2024

AbstractAiming at the problem that traditional methods are difficult to fully utilize the rich spectral information in hyperspectral images (HSI) and fail to capture the complex higher‐order relations in hyperspectral data, which leads to limited classification performance extreme learning machine and fails to further improve the classification accuracy of HSIs, the authors propose the hypergraph convolutional extreme learning machine (HGCELM) method. The method not only inherits all the advantages of extreme learning machine (ELM), but also embeds hypergraph convolution for feature selection, which is capable of handling higher‐order relations. This enables HGCELM to capture more complex relationships between nodes and provide richer representation capabilities. At the same time, the training speed advantage of ELM is retained, thus speeding up the model training process. Experimental results show that the proposed algorithm achieves better accuracy compared to other clustering algorithms.
MACN: A cascade defect detection for complex background based on mixture attention mechanism
Authors: Zhao Langyue , Wu Yiquan , Yuan Yubin , Tong Kang 
Published: April 2024

AbstractDefect detection in complex background is a critical issue. To address this issue, this paper proposes the mixture attention mechanism cascade network, in which the new channel attention network is linked with the spatial attention network to create an effective mixed attention network that takes advantage of their respective advantages, adaptively suppresses background noise, and highlights defect features. To ensure the efficiency and effectiveness of effective mixed attention network, the new channel attention network splices the output features of the global average pooling layer and the global maximum pooling layer and then sends the spliced features into a shared network, which is a one‐dimensional convolutional network, and uses cross‐channel interaction for fusion. Furthermore, in order to provide more discriminative feature representation, the authors extract the intermediate features of the region proposal network and input them into effective mixed attention network. Finally, the cascade head is used to refine the predicted bounding box to achieve high‐quality defect location. To demonstrate the superiority and usefulness of this method, it is compared to the latest method using widely used PCB and NEU data sets. A large number of trials demonstrate that this strategy outperforms other methods for detecting defects in complicated backgrounds.
Adaptive radar pulse detection design based on difference of box filter
Authors: Su Binbin , Liu Yongcai , Meng Jin 
Published: April 2024

AbstractPrecise radar pulse detection is the premise of electronic support measures. A constant false alarm rate (CFAR) detection algorithm based on difference of box (DOB) filter is proposed to realise low‐complexity and environment‐adaptive radar pulse detection, and the principle behind the proposed algorithm is revealed. Specifically, the DOB filter is adopted to extract the rising edges and falling edges of radar pulses, and the signal variation law of probability density functions (PDFs) during the process of DOB filter are first theoretically analysed. Based on the derived PDFs, dynamic detection threshold and fixed threshold factor for the proposed CFAR algorithm based on DOB filter are deduced to detect the presence of radar pulses. Furthermore, the closed‐form expression of the detection probability is derived. Simulations and on‐board field programmable gate arrays implementation verify the superiority of the proposed CFAR algorithm based on DOB filter. Simulation results show that the proposed algorithm performs well in detecting various types of pulse signals, the detection probability ≥99% on condition that the signal‐to‐noise ratio ≥3 dB and false alarm probability = 10−8. Moreover, the proposed CFAR algorithm based on DOB filter can deal with both singular pulses and pulse on pulse signals.
Observations of fan-spine topology by Solar Orbiter/EUI: Rotational motions and indications of Alfvén waves
Authors: Petrova E. , Van Doorsselaere T. , Berghmans D. , Parenti S. , Valori G. , Plowman J. 
Published: April 2024

Context. Torsional Alfvén waves do not produce any intensity variation and are therefore challenging to observe with imaging instruments. Previously, Alfvén wave observations were reported throughout all the layers of the solar atmosphere using spectral imaging.
Aims. We present a torsional Alfvén wave detected in an inverted Y-shaped structure observed with the HRIEUV telescope of the EUI instrument on board Solar Orbiter in its 174 Å channel. The feature consists of two footpoints connected through short loops and a spine with a length of 30 mm originating from one of the footpoints.
Methods. We made use of the simultaneous observations from two other instruments on board Solar Orbiter. The first one is the Polarimetric and Helioseismic Imager, which is used to derive the magnetic configuration of the observed feature. The second is the Spectral Imaging of the Coronal Environment (SPICE) instrument, which provided observations of intensity maps in different lines, including Ne VIII and C III lines. We also address the issues of the SPICE point spread function and its influence on the Doppler maps via performed forward-modeling analysis.
Results. The difference movie constructed from the HRIEUV images shows clear signatures of propagating rotational motions in the spine. We measured propagation speeds of 136 km s−1–160 km s−1, which are consistent with the expected Alfvén speeds. Evidence of rotational motions in the transverse direction with velocities of 26 km s−1–60 km s−1 serves as an additional indication of torsional waves being present. Doppler maps obtained with SPICE show a strong signal in the spine region. Under the assumption that the recovered point spread function is mostly correct, synthesized raster images confirm that this signal is predominantly physical.
Conclusions. We conclude that the presented observations are compatible with an interpretation of either propagating torsional Alfvén waves in a low coronal structure or the untwisting of a flux rope. This is the first time we have seen signatures of propagating torsional motion in the corona as observed by the three instruments on board Solar Orbiter.
Improved active sub-terahertz imaging system for parcel inspection
Authors: Boutemedjet Ayoub , Bezziou Boufateh , Zebellah Ali , Lazoul Mohamed 
Published: April 2024

Terahertz radiation has emerged as a prominent solution for imaging and detection beyond visible and infrared. Active terahertz imaging is a widely used technology in this context especially for security applications and screening. Such systems are built around an illuminating source, a detecting module and a beam shaping system to match the detectors geometry. The overall system performance is largely dependent on an optimized choice of these modules. In this work, an active sub-terahertz scanning system working at 100 GHz frequency is proposed to detect concealed objects in parcels and mail. The system is optimized based on an adapted design of the beam shaper and a preprocessing correction of the images to ensure uniformity of response and cleanness. The proposed system demonstrated through experimentation improved resolution with a uniform response along its detection area.
Tratamento não invasivo após luxação traumática anterior do joelho em artroplastia total de joelho com preservação do ligamento cruzado posterior: Relato de caso
Authors: Pires e Albuquerque Rodrigo Sattamini , Vivacqua Thiago , de Faria José Leonardo Rocha , Pavão Douglas Mello , Titonelli Victor Elias 
Published: April 2024

ResumoO caso relatado descreve uma luxação anterior traumática do joelho que era assintomática após uma artroplastia primária da articulação com preservação do ligamento cruzado posterior. A paciente descrita rolou acidentalmente sobre o joelho 6 anos após a intervenção cirúrgica. A luxação anterior traumática após artroplastia do joelho é um evento incomum, muitas vezes levando à revisão dos componentes protéticos devido às lesões ligamentares associadas. Uma abordagem não invasiva, composta por fixação externa temporária e um curto período de uso de joelheira rígida, foi realizada com sucesso.
Gene COL5A1 e o risco de lesões do LCA no esporte de equipe: Um relatório preliminar
Authors: Calò Carla Maria , Massidda Myosotis , Sorge Roberto , Tiloca Alessandra , Monteleone Giovanni 
Published: April 2024

Resumo
Objetivo: O objetivo deste estudo foi examinar a relação entre os polimorfismos do comprimento do fragmento de restrição (RFLP) BstUI C/T (rs 12722) e RFLP DpnII B1/B2 (rs 13946) COL5A1 e a ruptura do ligamento cruzado anterior (LCA) em atletas de esportes coletivos.
Métodos Sessenta e oito atletas de esportes coletivos (n = 36 mulheres e n = 32 homens) com ruptura do LCA (RLCA) sem contato ocorreram durante práticas esportivas (Grupo RLCA) e 42 jogadores saudáveis (n = 20 mulheres e n = 22 homens) (Grupo Controle) participaram do estudo. O DNA genômico foi extraído do swab bucal com o método salting out. Todas as amostras foram genotipadas para os polimorfismos rs12722 e rs13946 por reação em cadeia da polimerase (PCR) e análise de enzimas de restrição.
Resultados Nenhuma diferença significativa foi encontrada entre os grupos RLCA e Controle em idade, altura, peso corporal, índice de massa, prática esportiva (horas/semana) e distribuição de gênero entre os diferentes esportes coletivos. O grupo controle teve carreiras esportivas mais longas (p< 0,005). As distribuições de frequência dos polimorfismos de nucleotídeos COL5A1 DpnII estavam em equilíbrio de Hardy-Weinberg (EHW) em ambos os grupos (p do teste de Hardy-Weinberg (HW) > 0,005). As frequências genotípicas de COL5A1 BstUI RFLP C/C foram menores no grupo RLCA em comparação com o grupo Controle (p do teste HW = 0,001). Os genótipos combinados CC, B1B1 mostraram um efeito protetor contra a ruptura do LCA (OR = 83,3 / 16,7 = 5).
Conclusões O gene COL5A1 pode ser um dos fatores genéticos associados à RLCA em esportes coletivos.
Forma localizada da sinovite vilonodular pigmentada no ombro: Relato de caso tratado por artroscopia
Authors: Simmer Filho Jair , Ghidetti Thiago Henrique Cruz , Kautsky Raul Meyer 
Published: April 2024

ResumoA sinovite vilonodular pigmentada (SVNP), na forma localizada no ombro, é rara e pouco descrita na literatura. Apresentamos o caso de uma paciente de 58 anos, do sexo feminino, sem relato de trauma, com sintomas álgicos de 2 meses de evolução, sem irradiação para o membro, associados a perda de força de elevação e limitação progressiva da mobilidade ativa e passiva. A paciente realizou fisioterapia sem supervisão, sem melhora dos sintomas. A ressonância magnética (RM) do ombro mostrou imagem ovalada com aproximadamente 2 cm de diâmetro na região anteroinferior da articulação glenoumeral com focos de hipossinal em seu interior. Realizamos o tratamento artroscópico, com ressecção marginal da lesão e tenotomia da cabeça longa do bíceps. O resultado do exame anatomopatológico constatou SVNP. Após 4 anos e 5 meses da cirurgia, a paciente encontra-se sem dor, e apresenta recuperação total da função do ombro esquerdo, com RM de controle sem recidiva, o que demonstra a eficácia do tratamento artroscópico neste caso.
“Draw on your experience”: student diversity-driven internationalisation in a diverse International Relations course
Authors: Chovančík Martin 
Published: April 2024

AbstractThis study investigates the suitability of student-driven internationalisation of the curriculum in a diverse educational setting. Despite its vast educational potential, internationalisation of the curriculum is an often-missing component of general internationalisation even in programmes and courses with a diverse student body. To remedy this shortcoming in a course of international politics, I introduced a teaching and learning innovation, which encouraged students to use examples based on personal experiences and regional background—rather than merely from the assigned literature—during their arguments in preparation for and during biweekly seminars. In addition, the assessment criteria were shifted to support the sharing of information and knowledge among peers in this course, called “Theories of Cooperation and Conflict in International Relations”. The study uses a quasi-experimental setup and offers a comprehensive mixed-methods analysis of the innovation and finds that student learning and their classroom experience was positively impacted. While students did use notably more “own experience” examples and improved in their written preparatory work for the seminars, they turned to these very cautiously in the actual classroom debates. The findings are explained by the interplay between internationalisation and decolonisation of the classroom and the increased stakes in assessment criteria.
Internationalising student learning at the meso level: the impact of grassroots leadership in a university in Central Europe
Authors: Pleschová Gabriela , Simon Agnes 
Published: April 2024

AbstractThis study investigates the meso level impact of an academic development programme on internationalisation. We demonstrate the relevance of the framework of grassroots leadership in higher education in the Central European context and show how individual programme participants acting as grassroots leaders influence departmental attitudes and practices regarding internationalisation and student-centred learning. We identify two successful strategies—single-issue and multifaceted—for grassroots leadership. The study finds that established faculty member participants who are also active as grassroots leaders facilitate the spreading of the influence of an internationalisation programme beyond the individual level, highlighting the differences and similarities in the activism of faculty grassroots leaders in Central Europe vis-à-vis the USA.