bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is there a gender difference in concussion incidence and outcomes?
Authors: Dick R W 
Published: May 2009

Objective:To determine if there is a gender difference in the incidence and outcomes of sport concussion.Design:Critical literature review of sport concussion by gender.Intervention:PubMed and major sports medicine journals were reviewed using the keywords concussion and gender. Articles included in this paper were English prospective surveillance that included concussion as an injury option conducted over the past 10 years, involved data collected by qualified medical personnel (athletic trainers/therapists or medical doctors) and used injury rates as opposed to raw counts. Only data from sports (soccer, basketball and ice hockey) where actions, equipment and most rules were similar between genders were reviewed.Results:For the PubMed search, using “concussion” and “gender” as keywords, there were 51 articles. Ten studies (four in football (soccer), four in basketball and two in ice hockey, including high school, college and professional athletes) were included in the incidence portion of the paper. Nine of the studies showed higher absolute injury rates for female concussion compared to their male counterparts with four of them reaching statistical significance. Five of the studies (two football (soccer), two basketball and one ice hockey) examined concussion mechanism and in all cases, males had a higher absolute percent of player contact concussions while females had a higher absolute percentage of surface or ball contact concussion episodes. Two brain injury and four sport concussion outcome papers were reviewed. Traumatic brain injury outcome was shown to be worse in females than in males for a majority of measured variables; females also are shown to have different baseline and post-concussion outcomes on neuropsychological testing.Conclusions:After evaluating multiple years of concussion data in comparable sports, the evidence indicates that female athletes may be at greater risk for concussion than their male counterparts. There also is some evidence that gender differences exist in outcomes of traumatic brain injury and concussions. Because concussion is a clinical diagnosis often depending on self reporting and with no established biological marker or consistent symptoms/definitions, and because there is evidence that females are more honest in reporting general injuries than males, it is unclear whether the concussion incidence data, while generally consistent in showing a higher risk in females as compared to males in similar sports, is a true difference or is influenced by a reporting bias.
Knowledge transfer principles as applied to sport concussion education
Authors: Provvidenza C F , Johnston K M 
Published: May 2009

Objective:To (a) examine knowledge transfer literature and optimal learning needs as applied to healthcare professionals, coaches and student athletes; (b) apply the practice of knowledge transfer to sport concussion education resources; and (c) identify needs and make recommendations for optimising concussion education.Design:Qualitative literature review of knowledge transfer and concussion education literature.Intervention:Pubmed, Medline, Psych Info and Sport Discus databases were reviewed. 52 journal articles, 20 websites and 2 books were reviewed.Results:The methods in which individuals experience optimal learning varies and should be considered when developing effective concussion education strategies. Physician knowledge and performance are impacted by education outreach, interaction and reminder messages. Educational strategies associated with optimal learning for physio and athletic therapists include problem and evidence-based practice, socialisation and peer-assisted learning. From a coaching perspective, research supports the reflective process as a learning modality. Student athletes have strengths and weaknesses in different areas and so perform differently on activities requiring distinct strategies. Knowing the impact of sport concussion resources on knowledge enhancement and modifying attitudes and behaviours toward concussion requires evaluation strategies. Review of concussion resources using the perspective of knowledge transfer and methods for improvement is discussed.Conclusions:Knowledge transfer is a relatively new concept in sports medicine and its influence on enhancing concussion education is not well known. The needs and optimal learning styles of target audiences coupled with evaluation need to be a piece of the overall concussion education puzzle to effectively impact knowledge of and attitudes and behaviours towards sport concussion.
Effect of household passive smoking exposure on the risk of ischaemic heart disease in never-smoke female patients in Hong Kong
Authors: Ding D , Wing-Hong Fung J , Zhang Q , Wai-Kwok Yip G , Chan C-K , Yu C-M 
Published: May 2009

Objective:To investigate the relation between household passive smoking exposure and risk of ischaemic heart disease (IHD) among never-smoke female patients by a retrospective case-control analysis.Methods:This study recruited 314 patients with IHD who had never smoked and 319 controls who were admitted for other reasons in the same hospital during the same period. Subjects were interviewed about their exposure to household passive smoking. The dose metrics of passive smoking exposure were evaluated by using “pack years” and “hour years”, which indicated the cumulative amount and duration of exposure. The ORs and 95% CIs were computed by unconditional logistic regression, adjusted for other risk factors.Results:Subjects with passive smoking exposure were associated with higher risk of IHD (OR 1.51, 95% CI 1.01 to 2.27, p = 0.043) when compared to non-exposed subjects. Subjects exposed to an average of ⩾1 pack of cigarette per day had an OR of 1.69 (95% CI 1.07 to 2.68, p = 0.025). The OR was 1.52 for those exposed for ⩾5 years (95% CI 1.01 to 2.29, p = 0.043) and was 1.82 for those exposed ⩾4 h per day (95% CI 1.05 to 3.15, p = 0.032). Similarly, the risk of IHD increased with cumulative exposure duration, with an OR of 1.53 (95% CI 1.01 to 2.32, p = 0.043) at the exposure level ⩾5 pack years, and an OR of 1.61 (95% CI 1.03 to 2.52, p = 0.037) at the exposure level ⩾20 hour years. There was a significant dose-response association between the exposure measures and risk of IHD (p<0.01 for trend).Conclusion:Our data suggested an increased risk of IHD from passive household smoking in female never-smoke subjects, and demonstrated a dose-response association.
Choreographing Identities and Emotions in Organizations: Doing “Huminality” on a Geriatric Ward
Authors: Symons Gladys 
Published: May 2009

AbstractThis paper addresses the coconstruction of identities and emotions through the human/animal relationship, arguing that nonhuman animals can and do act as coagents in interspecies encounters. The paper narrates the extraordinary boundary-transgressing experiences of a particular kind of co(a)gency labeled “huminality” (the ongoing affective relationship of human and animal). An autoethnographic account of pet-visitation involving a woman, a West Highland white terrier named Fergus, and geriatric residents demonstrates the power of huminality to authorize the emergence and realization of different identities and selves. Examples include the intimate friend, the dignified self, the institutional resister, the gift-giver, and the available self. Huminality, in the emotional spacetime of the hospital, is rooted in empathy, concern, and affection. As ontological choreography, huminality takes us past the animal-Nature/human-culture frontier into uncharted territories of spacetime to engage in forms of life with nonhuman others. Encounters with animals, even on a geriatric ward, can transform our universe and our selves.
Variation in male mate preference for female size in the swordtail Xiphophorus malinche
Authors: Tudor Scarlett , Morris Molly 
Published: May 2009

AbstractMale and female mate preferences have the potential to influence one another, and such interactions could help explain variation in female mate preferences. In Xiphophorus malinche, larger females prefer asymmetrical males while smaller females prefer symmetrical males. We used a two-part preference test to determine if there were differences in mate preferences between symmetrical and asymmetrical males for female size that could influence female mate preference. We found no significant difference between symmetrical and asymmetrical male's preferences. A preference for large female size was detected during the time males directly interacted with females and in standard dichotomous choice tests that followed, as long as the males had been isolated less than 30 days. We did detect variation in male preference for female size depending on male size and the amount of time a male was isolated. These results suggest that variation in male mate preference is not likely to have produced the difference in female preference for symmetry between large and small females, but should be considered where females vary in their preference for male size. In addition, our results suggest that males may shift their preferences from large to small females depending on time since last mating opportunity.
Seasonal and vertical distribution of the entomopathogenic nematodes Heterorhabditis bacteriophora (TUR-H2) and Steinernema feltiae (TUR-S3) in turf and fallow areas
Authors: Susurluk Alper 
Published: May 2009

AbstractTo determine the seasonal movement of the dauer juvenile (DJ) stage of entomopathogenic nematodes, DJ of Heterorhabditis bacteriophora (TUR-H2) and Steinernema feltiae (TUR-S3) were applied to field plots (turf and fallow) and their vertical distribution in soil was monitored for 8 months (October to June) in Turkey. Most S. feltiae remained near the soil surface (0-15 cm deep) in both kinds of plots and throughout the study. By contrast, H. bacteriophora moved to 40 cm depth in fallow plots during winter months but remained mostly near the soil surface (0-15 cm deep) in turf plots throughout the study.
Molecular characterisation of some species of Mylonchulus (Nematoda: Mononchida) from Japan and comments on the status of Paramylonchulus and Pakmylonchulus
Authors: Araki Masaaki , Ahmad Wasim , Olia Majid , Minaka Nobuhiro 
Published: May 2009

AbstractComparative analyses of different regions of ribosomal DNA have become a popular tool in understanding the relationship among different species and genera and nematodes are no exception to this. In this study, molecular relationships were inferred from a nearly complete small subunit (SSU) of total 16 OTUs for five species of Mylonchulus, Paramylonchulus and Pakmylonchulus collected from various parts of Japan with two out-group taxa (Mononchus aquaticus and Clarkus papillatus) to examine the relationship among these species. Out of 1685 bp SSU rDNA sequences, phylogenetic trees using distance (NJ), parsimony and likelihood algorithms were performed. Obtained tree topologies were stable across algorithms and sequence data show that populations of the same species clustered together and four out of five species (M. brachyuris, M. hawaiiensis, M. oceanicus, M. sigmaturus) formed a monophyletic assemblage while M. mulveyi formed a sister group. Populations of species lacking subventral teeth but with a double gonad (M. oceanicus) stand with other Mylonchulus species, thereby confirming the synonymy of Pakmylonchulus, while populations with a narrow buccal cavity with few rows of denticles, no subventral teeth and a single prodelphic gonad (M. mulveyi = Paramylonchulus mulveyi) support to some extent the validity of the genus Paramylonchulus. Though a preliminary investigation, it is the first report on molecular relationships in Mylonchulus, probably a paraphyletic genus. Our results suggest that SSU rDNA sequence data are useful in understanding the relationship between genera and species.
Identification of putative expansin-like genes from the pine wood nematode, Bursaphelenchus xylophilus, and evolution of the expansin gene family within the Nematoda
Authors: Li Hongmei , Kennedy Malcolm , Jones John , Karim Nurul , Kikuchi Taisei , Moens Maurice 
Published: May 2009

AbstractWe report the cloning and characterisation of genes encoding expansin-like proteins from the pine wood nematodes, Bursaphelenchus xylophilus and B. mucronatus. A small family of genes is present in both species and the Bursaphelenchus genes are most similar to expansins and expansin-like proteins from the potato cyst nematode Globodera rostochiensis and root-knot nematodes. Molecular modelling suggests that the genes could encode a protein with a structure similar to that of functionally characterised expansins. Expression analysis showed that the Bursaphelenchus expansin-like genes are expressed solely in the pharyngeal gland cells, implying a role in the host-parasite interaction, most likely in assisting migration through the plant. Some G. rostochiensis and root-knot nematode expansins are composed of a carbohydrate-binding domain coupled to an expansin domain but no carbohydrate binding domain is present on any of the Bursaphelenchus sequences. We suggest a model for evolution of the expansin gene family within the plant-parasitic nematodes of the Tylenchida and Aphelenchida.
Virulence of entomopathogenic nematodes to different stages of the flatheaded root borer, Capnodis tenebrionis (L.) (Coleoptera: Buprestidae)
Authors: Morton Ana , García-del-Pino Fernando 
Published: May 2009

AbstractThe virulence of 14 Steinernema feltiae isolates, one S. carpocapsae and three Heterorhabditis bacteriophora isolates was compared in the laboratory against larvae, pupae and adults of the flatheaded root borer, Capnodis tenebrionis. Larval mortality ranged from 50 to 100% and pupae mortality from 0 to 70%. Adults were exposed to different nematode concentrations, 50 and 100 infective juveniles/cm2. Steinernema feltiae caused the highest mortality at the two doses tested, reaching 66.7% and 100%, respectively. Significant differences in mortality between C. tenebrionis males and females were observed. The differences in virulence observed at each stage of C. tenebrionis vary within a species and can be higher than differences among species. The results of this study suggest that some of the isolate strains have potential for improved biological control of C. tenebrionis.
Seasonal change in susceptibility of Pinus densiflora to Bursaphelenchus xylophilus infection, determined from the number of nematodes passing through branch sections
Authors: Matsunaga Koji , Togashi Katsumi 
Published: May 2009

AbstractPine wilt disease by Bursaphelenchus xylophilus has been causing devastating damage to Pinus densiflora and P. thunbergii forests in Japan. Reforestation using resistant trees is one of the most effective control measures. In this study we examined the seasonal change in the number of nematodes passing through 5 cm long P. densiflora branch sections during 24 h, to determine the season of greatest susceptibility when resistant candidates can be identified easily. We inoculated 200 nematodes of each of four B. xylophilus and one B. mucronatus isolate on the cut end of individual branch sections. The overall seasonal change in the number of nematodes passing was similar among the five isolates. Peaks occurred in August and between December and February for four isolates. A virulent isolate, T-4, exhibited remarkable fluctuations, with the highest peak in August, suggesting that a test in August with T-4 is most informative. Another study showed that the passage ability, which is a measure of the dispersal ability in branches, was low for eggs and second-stage propagative juveniles and high for other developmental stages. This indicates that the composition of developmental stages in the inoculum is important when comparing the numbers of passing nematodes obtained on different occasions and in different places.
Nothing Personal: An Empirical Phenomenological Study of the Experience of “Being-on-an-SSRI”
Authors: Teal Jay 
Published: May 2009

AbstractThe process by which SSRIs reduce “depressive symptoms” remains obscure. Biochemical, functional, and taker self-assessment evidences for the “corrective” nature of this process are inconclusive and ultimately incapable of appropriately addressing the meaning of being “anti-depressed.” In light of their growing prevalence, an understanding of the ways in which SSRIs alter takers' lived worlds is crucial for those who are presently taking them or considering doing so, for those recommending their use, and for those inhabiting societies increasingly composed of people who use them. This study found that the essential lived characteristic of “being-on-SSRIs” was increased distance or disconnection between takers their worlds, a disruption which showed itself most prominently within the emotional, bodily, social, and existential realms. Depression and anxiety are intense modes of relation, and the alteration of meaningful connections is characterized largely by participants as a disruption. SSRIs succeed in alleviating pain and suffering. However, takers' attunement becomes a relatively “a-motional” acceptance of whatever occurs in their world. Their stance becomes an essentially passive approach toward a world that can no longer “touch” them and to which takers are no longer responsible, and numbing “side-effects” are inseparable from the “treatment effect.”
Temporality and Asperger's Syndrome
Authors: Zukauskas Patricia Ribeiro , Assumpção, Jr. Francisco Baptista , Silton Nava 
Published: May 2009

AbstractAsperger's syndrome is a pervasive developmental condition characterized by features of autism. As observed in clinical practice, individuals with Asperger's syndrome present an impairment related to inflexibility in their everyday routine, an immediate manner of experiencing and relating, and difficulties in estimating periods of time. Following a phenomenological perspective, this study is an attempt to examine these aforementioned aspects in terms of temporality. Thirteen participants with Asperger's syndrome, from 13 to 20 years old, were interviewed about their experience of periods of time, personal history, their past, present and future; and their concept of time and finitude. After the interviews, it was possible to identify three general themes which emerged in the invariant aspects of their experience of time: factual experience of present and future dimensions, chronological time and the past experience. Moreover, participants' descriptions evidenced aspects of experience based on the specificity of lived facts and a sense of time specifically related to what was lived in the past.
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways
Authors: Jones Chris I. , Bray Sarah , Garner Stephen F. , Stephens Jonathan , de Bono Bernard , Angenent Will G. J. , Bentley David , Burns Philippa , Coffey Alison , Deloukas Panos , Earthrowl Mark , Farndale Richard W. , Hoylaerts Marc F. , Koch Kerstin , Rankin Angela , Rice Catherine M. , Rogers Jane , Samani Nilesh J. , Steward Michael , Walker Adam , Watkins Nicholas A. , Akkerman Jan-Willem , Dudbridge Frank , Goodall Alison H. , Ouwehand Willem H. 
Published: May 2009

AbstractPlatelet response to activation varies widely between individuals but shows interindividual consistency and strong heritability. The genetic basis of this variation has not been properly explored. We therefore systematically measured the effect on function of sequence variation in 97 candidate genes in the collagen and adenosine-diphosphate (ADP) signaling pathways. Resequencing of the genes in 48 European DNA samples nearly doubled the number of known single nucleotide polymorphisms (SNPs) and informed the selection of 1327 SNPs for genotyping in 500 healthy Northern European subjects with known platelet responses to collagen-related peptide (CRP-XL) and ADP. This identified 17 novel associations with platelet function (P < .005) accounting for approximately 46% of the variation in response. Further investigations with platelets of known genotype explored the mechanisms behind some of the associations. SNPs in PEAR1 associated with increased platelet response to CRP-XL and increased PEAR1 protein expression after platelet degranulation. The minor allele of a 3′ untranslated region (UTR) SNP (rs2769668) in VAV3 was associated with higher protein expression (P = .03) and increased P-selectin exposure after ADP activation (P = .004). Furthermore the minor allele of the intronic SNP rs17786144 in ITPR1 modified Ca2+ levels after activation with ADP (P < .004). These data provide novel insights into key hubs within platelet signaling networks.
PCOPGene-Net: Holistic Characterisation of cellular states from microarray data based on continuous and non-continuous analysis of gene-expression relationships
Authors: Huerta Mario , Cedano Juan , Peña Dario , Rodriguez Antonio , Querol Enrique 
Published: May 2009

Abstract

Background
Microarray technology is so expensive and powerful that it is essential to extract maximum value from microarray data, specially from large-sample-series microarrays. Our web tools attempt to respond to these researchers' needs by facilitating the possibility to test and formulate from a hypothesis to entire models under a holistic point of view.

Results
PCOPGene-Net is a web application for facilitating the study of the relationships among gene expressions under microarray conditions, to classify these conditions and to study their effect on expression relationships. Furthermore, the system guides the researcher in the navigation through the microarray data by providing the most suitable genes and information for the researcher's interests at each moment. We achieve all of these by means of the zoom-out operation, the zoom-in operation, the non-continuous analysis and crossing the PCOPGene results with external data-servers.

Conclusion
PCOPGene-Net helps to identify cellular states and the genes involved in these. All of that is accomplished in a flexible way, guided by the researcher's interests and taking advantage of the ability of our system to relate gene expressions, even when these relationships are non-continuous and cannot be found using linear or non-linear analytical methods. Currently, our tools are used for tumour-progression study from a holistic point of view.
Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF
Authors: Yang Haiwei , Wei Jifu , Zhang Huiyun , Lin Liyan , Zhang Wei , He Shaoheng 
Published: May 2009

Abstract

Backgroud
Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported to be able to alter expression of TLRs and cytokine production in neutrophils. However, whether GM-CSF modulates the expression of TLR and cytokine production in mast cells is not clear.

Results
Using flow cytometry and real time PCR techniques, we found that GM-CSF upregulated expression of TLR3 and TLR7 in P815 cells in a concentration dependent manner. GM-CSF also provoked approximately up to 2.4 and 2.3 fold increase in IL-13 and IL-6 release from P815 cells, respectively following 16 h incubation. GM-CSF induced IL-13 secretion, TLR3 and TLR7 expression appeared to be through activation of mitogen-activated protein kinase (MAPK) and phosphotidylinositol 3-kinase (PI3K)/Akt signaling pathways, whereas GM-CSF elicited IL-6 release seemed via Akt signaling pathway. At 10 ng/ml, GM-CSF significantly enhanced R-848-induced IL-6 release from P815 cells.

Conclusion
The ability of GM-CSF in modulation of expression of TLR3 and TLR7 in P815 mast cells and in stimulation of IL-13 and IL-6 release from P815 mast cells in vitro suggests that GM-CSF might play an important role in enhancing the innate immune responses of mast cell to viral infection