bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Application of FAM Ligands in the Metal‐Promoted Catalytic Enantioselective Synthesis of Organic Compounds
Authors: Dogan Ozdemir , Garner Philip P. , Bulut Adnan 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Biaryls by the ′Lactone Method′
Authors: Bringmann Gerhard , Gulder Tanja , Gulder Tobias A. M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diterpenoid Alkaloids
Authors: Wang Feng‐Peng , Chen Qiao‐Hong , Liu Xiao‐Yu 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Post‐PKS Tailoring Steps in Natural Product‐Producing Actinomycetes from the Perspective of Combinatorial Biosynthesis
Authors: Olano Carlos , Mendez Carmen , Salas Jose A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Applications. How Click Chemistry Brought Biomimetic Models to the Next Level: Electrocatalysis under Controlled Rate of Electron Transfer
Authors: Decreau Richard A. , Collman James P. , Hosseini Ali 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pathophysiological Roles of Transient Receptor Potential Channels in Glial Cells
Authors: Shirakawa Hisashi , Nakagawa Takayuki , Kaneko Shuji 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Engineering of Nanometer‐Sized Cross‐Linked Hydrogels for Biomedical Applications
Authors: Oh Jung Kwon 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Positional Selectivity in Electrophilic Substitution in π‐Excessive Heteroaromatics
Authors: Belen'kii L. I. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: In silico Approaches for Fragment‐Based Drug Design
Authors: Takahashi Osamu , Masuda Yoshiaki , Muroya Ayumu , Furuya Toshio 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Human papillomavirus status in head and neck cancer
Authors: Shuman Andrew G. , Wolf Gregory T. 
Published: June 2010

AbstractHuman papillomavirus (HPV) is an emerging causative factor for squamous carcinoma of the oropharynx and perhaps other head and neck cancers. There is a great deal of uncertainty regarding the clinical significance and implications of HPV status in this patient population. As a result, there is no established protocol for informing patients of the potential link between viral infection and their cancer. This paper discusses some of the ethical issues involved with informing head and neck cancer patients of their HPV status, recognizing the dilemma posed by unresolved clinical questions and the need to respect the autonomy of patients by disclosing relevant information. Cancer 2010; 116:4221–6. © 2010 American Cancer Society.
Methylene Blue Adsorption on a DMPA Lipid Langmuir Monolayer
Authors: Giner Casares Juan José , Camacho Luis , Martín‐Romero Maria Teresa , López Cascales José Javier 
Published: June 2010

AbstractAdsorption of methylene blue (MB) onto a dimyristoylphosphatidic acid (DMPA) Langmuir air/water monolayer is studied by molecular dynamics (MD) simulations, UV reflection spectroscopy and surface potential measurements. The free‐energy profile associated with MB transfer from water to the lipid monolayer shows two minima of −66 and −60 kJ mol−1 for its solid and gas phase, respectively, corresponding to a spontaneous thermodynamic process. From the position of the free‐energy minima, it is possible to predict the precise location of MB in the interior of the DMPA monolayer. Thus, MB is accommodated in the phosphoryl or carbonyl region of the DMPA Langmuir air/water interface, depending on the isomorphic state (solid or gas phase, respectively). Reorientation of MB, measured from the bulk solution to the interior of the lipid monolayer, passes from a random orientation in bulk solution to an orientation parallel to the surface of the lipid monolayer when MB is absorbed.
Systematic Variation of Length Ratio and the Formation of Smectic A and Smectic C Phases
Authors: Kapernaum Nadia , Hartley C. Scott , Roberts Jeffrey C. , Schoerg Florian , Krueerke Daniel , Lemieux Robert P. , Giesselmann Frank 
Published: June 2010

AbstractThe phase diagrams of four binary mixtures of chemically similar smectogenic mesogens differing only in molecular length are investigated. In these bidisperse systems the length ratio varies systematically. The phase diagrams show the stabilization of the smectic A and the destabilization of the smectic C phase with increasing length ratio as a general trend. Detailed small‐angle X‐ray diffraction and electro‐optic measurements revealed a decrease in smectic translational order and a continuous reduction of the tilt angle with increasing length difference. These surprising results are of general interest for the understanding of the structure and dynamics of smectic phases. The remarkably strong impact of the length difference on the smectic layer structure and the phase behavior is discussed from a mechanistic point of view taking into account sterical interactions. For the observed structural changes in these bidisperse smectics we propose pronounced out‐of‐layer fluctuations with increasing length difference as driving force, causing neighboring molecules within nearest layer into a smectic A‐like packing.
TEM, chemical etching and FTIR characterization of ZnTe grown by physical vapor transport
Authors: Trigubó A. B. , Di Stefano M. C. , Gilabert U. , Martínez A. M. , D'Elía R. , Cánepa H. , Heredia E. , Aguirre M. H. 
Published: June 2010

AbstractZnTe ingots were obtained by the physical transport method, using an in‐house designed and built tubular furnace. The growth of ZnTe subsequently to the growth of a seed of this material allowed obtaining an ingot formed by only one large and single crystalline grain. TEM was used for the characterization of the as‐grown ZnTe single crystal ingots and commercial single‐crystalline wafers of the same material but grown by a higher temperature and more expensive technique, the Bridgman method. Both materials show very good crystalline microstructure, although some stacking faults were found in the commercial one. The infrared transmittance spectra of both materials were measured by FTIR and some differences, most likely due to differences in raw materials and growth methods, were found. The effectiveness and convenience of several chemical etchants to obtain the dislocation density and the minimal misorientation between adjacent subgrains in the as‐grown ZnTe wafers were checked. It has been found as the most advantageous the chemical solution that does not produce over‐etching. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Electrical conductivity of sulfamic acid single crystals
Authors: Santhosh Kumar A. , Varughese G. , Iype L. , Rajesh R. , Joseph G. , Louis G. 
Published: June 2010

AbstractSingle crystals of sulfamic acid have been grown by the method of slow evaporation at constant temperature. DC electrical conductivity was measured in the temperature range 300 ‐ 440 K along a, b and c‐axes. Conductivity measurements show slope change near 330 K and 410 K. The slope change observed around 330 K may be attributed as due to a phase transition which has been well supported by the DSC and DTA measurements. Slope change observed around 410 K is attributed as the onset of the thermal decomcoposition as evidenced by TGA curve. TGA studies show the crystal is very stable up to 440 K. Activation energies for the conduction process are calculated for all measured crystallographic directions. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Spin‐Hamiltonian parameters for Dy3+ion at the trigonal 12‐fold coordinated La3+site of La2Mg3(NO3)12·24H2O
Authors: Yang Wei‐Qing , Zheng Wen‐Chen , Liu Hong‐Gang 
Published: June 2010

AbstractThe spin‐Hamiltonian parameters (gfactorsg‖,g⊥and hyperfine structure constants161A‖,161A⊥,163A‖,163A⊥) for161Dy3+and161Dy3+isotopes in the trigonal 12‐fold coordinated La3+site of La2Mg3(NO3)12·24H2O crystal are calculated from a diagonalization (of energy matrix) method. In the method, the Zeeman and hyperfine interaction terms are added to the conventional Hamiltonian used in the studies of crystal‐field energy levels, and a 66×66 energy matrix concerning the ground multiplet6H15/2and the first to fifth excited multiplets6H13/2,6H11/2,6H9/2,6H7/2and6H5/2are applied. The calculated results are discussed. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Ring oscillator structures with explicitly separated nonlinearity
Authors: Elwakil A. S. 
Published: June 2010

AbstractIn this letter, we propose RC and LC nonlinear sinusoidal ring oscillator structures which can also generate subsidiary quadrature outputs. A tanh(x) nonlinearity is employed and is explicitly separated from the oscillators' linear building block (a first‐order all‐pass filter). Numerical and spice simulation results are given. Copyright © 2010 John Wiley & Sons, Ltd.
Seismic vulnerability of historical masonry buildings for different earthquake characteristics: Case study of the mosque of Takiyya al‐Sulaymaniyya
Authors: Jäger Wolfram , Bakeer Tammam 
Published: June 2010

AbstractDifferent factors influence the collapse behaviour of masonry structures, and one of the major factors is the characteristics of the earthquake itself. This effect is going to be more complicated for historical constructions, which involve different structure members of different geometries.The present study focuses on the effect of earthquake characteristics on the collapse behaviour of historical masonry structures. The effect of earthquake direction and the frequency content of the earthquake are mainly considered. A brief background of the selected case study and modelling process are presented. The geometry of the whole structure is created using micro modelling strategy. The collapse analysis of the structure is performed under artificial model based on the earthquake characteristics. Unidirectional earthquake are applied to the structure from different angels in order to investigate the weakest situation. Finally, different earthquake models are generated with different frequency contents according the soil profiles and applied consequently on the structure to explore the worst situation.Seismische Gefährdung von historischen Mauerwerksbauten infolge Erdbebeneinwirkung — Fallstudie: Die Moschee von Takiyya al‐Sulaymaniyya. Verschiedene Faktoren beeinflussen das Versagen von Mauerwerksstrukturen. Ein wesentlicher ist die Erdbebeneinwirkung selbst. Deren Charakteristik und Auswirkung ist für historische Konstruktionen, welche aufgrund der verschiedenen verwendeten und zusammenwirkenden Tragelemente und der großen Bandbreite geometrischer Formen eine komplexe Versagensabhängigkeit aufweisen, noch schwieriger einzuschätzen.Die in diesem Beitrag beschriebene Fallstudie befasst sich mit dem Verhalten historischer Mauerwerkskonstruktionen beim Versagen infolge einer Erdbebenbelastung. Die Auswirkungen von Richtung und Frequenz eines Erdbebens sind die Hauptschwerpunkte der Studie. Ein kurz gefasster Hintergrund der gewählten Fallstudie und der Modellierungsprozess werden vorgestellt. Die Geometrie der gesamten Konstruktion wurde mittels Mikromodellierung erstellt. Die Versagensanalyse der Konstruktion ist mittels eines künstlich generierten Erdbebens durchgeführt worden. Das einachsige Erdbeben wurde mit variierenden Richtungswinkeln auf das Modell angesetzt, um die schwächste Achse zu ermitteln. Den Abschluss bildete die Erzeugung von verschiedenen Erdbebenverläufen in Abhängigkeit der Bodenprofile und Anwendung auf die Konstruktion, um wiederum den ungünstigsten Fall zu ermitteln.
Peoniflorin prevents the adhesion between inflammatory endothelial cells and leukocytes through inhibiting the activation of MAPKs and NF‐κB
Authors: Xu Huan , Gao Xinghua , Song Jie , Wang Fengyun , Xu Zhao , Lu Dan , Xu Xianxiang , Xia Yufeng , Dai Yue 
Published: June 2010

AbstractThe vascular endothelium can be activated by multiple factors, including lipopolysaccharide (LPS) functioning as a key component of the inflammatory response. Activated endothelium promotes the recruitment of leukocytes mainly by releasing various adhesion molecules and amplifies inflammation via a feedback loop. Peoniflorin, the main active constituent of the roots of Paeonia lactiora Pall., possesses anti‐inammatory, anti‐infective, and anti‐platelet aggregative properties. To elucidate the anti‐inammatory mechanism of peoniflorin, the present study was conducted to address its effects on the adhesion of inflammatory endothelial cells to leukocytes. Peoniflorin substantially reduced adhesion of either human acute monocytic leukemia cells (THP‐1) or human acute promyelocytic leukemia cells (HL‐60) to LPS‐stimulated human umbilical vein endothelial cells (HUVECs). It also markedly down‐regulated the expression of E‐selectin at both the gene and protein levels. However, peoniflorin only slightly reduced expression of intercellular adhesion molecule‐1 (ICAM‐1). Signal pathway analysis indicated that peoniflorin reduced phosphorylation of c‐Jun NH2‐terminal kinase (JNK) and p38 kinase, as well as the phosphorylation and degradation of IκB‐α in HUVECs. These findings suggest that prevention of the adhesion between inflammatory endothelial cells and leukocytes contributes, at least partially, to the anti‐inflammation action of peoniflorin. The anti‐adhesion mechanisms of peoniflorin were involved in the down‐regulation of the activation of mitogen‐activated protein kinases (MAPKs) and nuclear factor‐kappa B (NF‐κB), and a reduction of adhesion molecule expressions in endothelial cells. Drug Dev Res 2010.© 2010 Wiley‐Liss, Inc.
Competition between SLP76 and LAT for PLCγ1 binding in resting T cells
Authors: Jung Seung Hee , Jeong Ji Hye , Seul Hee Jung , Lee Jong Ran 
Published: June 2010

AbstractThe constitutive interaction between the P1 domain (a 67‐amino‐acid functional domain within the proline‐rich region) of SLP76 and the SH3 domain of phospholipase Cγ1 (PLCγ1) has been shown. To determine the significance of the interaction between SLP76 and PLCγ1 in resting T cells, we examined molecules associated with PLCγ1 in the absence of both SLP76 and, more specifically, the P1 domain of SLP76. Using a mutant Jurkat T‐cell line, we showed that PLCγ1 associated with LAT when the constitutive association with SLP76 was blocked. We also found that the PLCγ1 association with LAT occurred in the membranes of resting T cells. Further experiments demonstrated that LAT competed with SLP76 for PLCγ1 binding and that the LAT interaction with PLCγ1 was mediated by the SH3 domain of PLCγ1. Collectively, these results suggest that the constitutive association of SLP76 with PLCγ1 is required to prevent the association with LAT as well as the premature recruitment of PLCγ1 to the cell membrane.
Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation
Authors: Baru Abdul Mannan , Hartl Andrea , Lahl Katharina , Krishnaswamy Jayendra Kumar , Fehrenbach Heinz , Yildirim Ali Ö. , Garn Holger , Renz Harald , Behrens Georg M. N. , Sparwasser Tim 
Published: June 2010

AbstractRecent studies highlight the role of Treg in preventing unnecessary responses to allergens and maintaining functional immune tolerance in the lung. We investigated the role of Treg during the sensitization phase in a murine model of experimental allergic airway inflammation by selectively depleting the Treg population in vivo. DEpletion of REGulatory T cells (DEREG) mice were depleted of Treg by diphtheria toxin injection. Allergic airway inflammation was induced using OVA as a model allergen. Pathology was assessed by scoring for differential cellular infiltration in bronchoalveolar lavage, IgE and IgG1 levels in serum, cytokine secretion analysis of lymphocytes from lung draining lymph nodes and lung histology. Use of DEREG mice allowed us for the first time to track and specifically deplete both CD25+ and CD25− Foxp3+ Treg, and to analyze their significance in limiting pathology in allergic airway inflammation. We observed that depletion of Treg during the priming phase of an active immune response led to a dramatic exacerbation of allergic airway inflammation in mice, suggesting an essential role played by Treg in regulating immune responses against allergens as early as the sensitization phase via maintenance of functional tolerance.
Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system
Authors: Prevot Nicolas , Briet Claire , Lassmann Hans , Tardivel Isabelle , Roy Edwige , Morin Joëlle , Mak Tak W. , Tafuri Anna , Boitard Christian 
Published: June 2010

AbstractNOD mice spontaneously develop insulin‐dependent diabetes around 10–40 wk of age. Numerous immune gene variants contribute to the autoimmune process. However, genes that direct the autoimmune response toward β cells remain ill defined. In this study, we provide evidence that the Icos and Icosl genes contribute to the diabetes process. Protection from diabetes in ICOS−/− and ICOSL−/− NOD mice was unexpectedly associated with the development of an autoimmune disorder of the neuro‐muscular system, characterized by myositis, sensory ganglionitis and, to a reduced extent, inflammatory infiltrates in the CNS. This syndrome was reproduced upon adoptive transfer of CD4+ and CD8+ T cells from diseased donors to naïve NOD.scid recipients. Our data further show that protection from diabetes results from defective activation of autoimmune diabetogenic effector T cells in ICOS−/− NOD mice, whereas acceleration of diabetes in BDC2.5 ICOS−/− NOD mice is induced by a dominant defect in Treg. Taken together, our findings indicate that costimulation signals play a key role in regulating immune tolerance in peripheral tissues and that the ICOS/ICOSL costimulatory pathway influences the balance between Treg and diabetogenic effector T cells.
Molybdenum and Tungsten Nitrosyl Complexes in Hydrogen Activation
Authors: Dybov Alexander , Blacque Olivier , Berke Heinz 
Published: June 2010

AbstractTwo transition‐metal hydride complexes of the type [M(dippe)2(NO)(H)] [M = W (2a), Mo (2b); dippe = 1,2‐bis(diisopropylphosphanyl)ethane] have been prepared by the reaction of [M(dippe)2(NO)(Cl)] [M = W (1a), Mo (1b)] with LiBH4. The nitrosyl groups of the tungsten complexes 1a and 2a are capable to coordinate a LiBH4 molecule to form the stable adducts W(dippe)2(Cl)(NO···LiBH4) (1c) and W(dippe)2(H)(NO···LiBH4) (2c). Addition of ethylenediamine to a toluene solution of 2c led to rupture of the 2c adduct and afforded 2a in good yield. After the interaction of 2a with [H(Et2O)][BF4], the stable seven‐coordinated cationic dihydride [W(dippe)(H)2(dippe)(NO)][BF4] (6a) was isolated. The reaction between 2b and [H(Et2O)][BF4] led to the formation of [Mo(dippe)2(NO)(FBF3)] (6b) in which BF4– was found to be coordinated to the metal centre. The [H(Et2O)2][BArF4] [ArF = 3,5‐(CF3)2C6H3] acid interacted with 2a to yield the seven‐coordinated complex [W(dippe)(H)2(dippe)(NO)][BArF4] (5a) similar to 6a. In the reaction between 2b and [H(Et2O)2][BArF4], the 16e– five‐coordinated complex [Mo(dippe)2(NO)][BArF4] (4b) was formed. X‐ray diffraction revealed that 4a has a weak agostic interaction trans to the NO ligand. Complex 4b was found to react rapidly with hydrogen gas under ambient conditions to form the dihydride complex [Mo(dippe)(H)2(dippe)(NO)][BArF4] (5b), which is unstable in the absence of a hydrogen atmosphere. The equilibrium constant for the reversible reaction of 4b with hydrogen was found to be K = 2.6 bar–1 at 25 °C. Complex 4b was tested as a catalyst for acetone hydrogenation; a maximum TON of 7 was found.
A Joint Experimental and Theoretical Investigation on Nonlinear Optical (NLO) Properties of a New Class of Push–Pull Spirobifluorene Compounds
Authors: Rizzo Fabio , Cavazzini Marco , Righetto Stefania , De Angelis Filippo , Fantacci Simona , Quici Silvio 
Published: June 2010

AbstractA new class of push–pull spirobifluorene compounds 1–5 has been synthesized. The nonlinear optical (NLO) properties (first and second hyperpolarizability β and γ, respectively)of spirobifluorene derivatives have been investigated forthe first time using electric field induced second harmonic(EFISH) and third harmonic generation (THG) methods. Moreover, a comparison with the corresponding push–pullfluorene monomers 1a–5a was carried out. Besides the experimental data, ab initio theoretical calculations on structural, electronic, and optical properties were carried out for all compounds. The analyses indicate that an increase in the β and γ values occur on passing from monomers to dimers without compromising the optical transparency.
A General Methodology for the Enantioselective Synthesis of 1‐Substituted Tetrahydroisoquinoline Alkaloids
Authors: Amat Mercedes , Elias Viviane , Llor Núria , Subrizi Fabiana , Molins Elies , Bosch Joan 
Published: June 2010

AbstractStarting from tricyclic lactam 2, which is easily accessible by cyclocondensation of δ‐oxoester 1 with (R)‐phenylglycinol, a three‐step synthetic route to enantiopure 1‐substituted tetrahydroisoquinolines, including 1‐alkyl‐, 1‐aryl‐, and 1‐benzyltetrahydroisoquinoline alkaloids, as well as the tricyclic alkaloid (–)‐crispine A, has been developed. The key step is a stereoselective α‐amidoalkylation reaction using the appropriate Grignard reagent.