bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypochlorite-induced oxidative stress elevates the capability of HDL in promoting breast cancer metastasis
Authors: Pan Bing , Ren Hui , Lv Xiaofeng , Zhao Yangyu , Yu Baoqi , He Yubin , Ma Yijing , Niu Chenguang , Kong Jinge , Yu Fangzhu , Sun Wen-bing , Zhang Youyi , Willard Belinda , Zheng Lemin 
Published: March 2012

Abstract

Background
Previous studies suggest that oxidative stress plays an important role in the development of breast cancer. There is a significant inverse relationship between HDL and the risk and mortality of breast cancer. However, it is well known that under conditions of oxidative stress, such as breast cancer, HDL can be oxidatively modifiedand these modifications may have an effect on the functions of HDL. The purpose of this study is to determine the different effects of normal and oxidized (caused by hypochlorite-induced oxidative stress) HDL on breast cancer cell metastasis.

Methods
Human breast cancer cell lines were treated with normal and hypochlorite-oxidized HDL, and then cell metastasis potency in vivo and the abilities of migration, invasion, adhesion to HUVEC and ECM in vitro were examined. Integrin expression and PKC activity were evaluated, and PKC inhibitor and PKC siRNA was applied.

Results
We found hypochlorite-oxidized HDL dramatically promotes breast cancer cell pulmonary metastasis (133.4% increase at P < 0.0 l for MDA-MB-231 by mammary fat pad injection; 164.3% increase at P < 0.01 for MCF7 by tail vein injection) and hepatic metastasis (420% increase at P < 0.0 l for MDA-MB-231 by mammary fat pad injection; 1840% fold increase at P < 0.001 for MCF7 by tail vein injection) in nude mice, and stimulates higher cell invasion (85.1% increase at P < 0.00 l for MDA-MB-231; 88.8% increase at P < 0.00 l for MCF7;), TC-HUVEC adhesion (43.4% increase at P < 0.00 l for MDA-MB-231; 35.2% increase at P < 0.00 l for MCF7), and TC-ECM attachment (41.0% increase at P < 0.00 l for MDA-MB-231; 26.7% increase at P < 0.05 for MCF7) in vitro compared with normal HDL. The data also shows that the PKC pathway is involved in the abnormal actions of hypochlorite-oxidized HDL.

Conclusions
Our study demonstrated that HDL under hypochlorite-induced oxidative stress stimulates breast cancer cell migration, invasion, adhesion to HUVEC and ECM, thereby promoting metastasis of breast cancer. These results suggest that HDL-based treatments should be considered for treatment of breast cancer patients.
Modeling interaction using trust and recommendation in ubiquitous computing environment
Authors: Iltaf Naima , Ghafoor Abdul , Hussain Mukhtar 
Published: March 2012

Abstract
To secure computing in pervasive environment, an adaptive trust and recommendation based access control model (based on human notion of trust) is proposed. The proposed model provides support to calculate direct as well as indirect trust based on recommendations. It handles situations (by itself) both in which the requesting entity has a past experience with the service and a stranger entity requesting to access the service without any past interaction with the service. It encompasses the ability to reason human cognitive behavior and has the capability to adjust in accordance with behavioral pattern changes. X-bar control chart is used to handle malicious recommendation. The defense mechanisms incorporated by proposed model against attacks such as bad mouthing attack, oscillating behavior attack and conflicting behavior attack are also demonstrated.
The effects of multi-domain versus single-domain cognitive training in non-demented older people: a randomized controlled trial
Authors: Cheng Yan , Wu Wenyuan , Feng Wei , Wang Jiaqi , Chen You , Shen Yuan , Li Qingwei , Zhang Xu , Li Chunbo 
Published: March 2012

Abstract

Background
Whether healthy older people can benefit from cognitive training (CogTr) remains controversial. This study explored the benefits of CogTr in community dwelling, healthy, older adults and compared the effects of single-domain with multi-domain CogTr interventions.

Methods
A randomized, controlled, 3-month trial of CogTr with double-blind assessments at baseline and immediate, 6-month and 12-month follow-up after training completion was conducted. A total of 270 healthy Chinese older people, 65 to 75 years old, were recruited from the Ganquan-area community in Shanghai. Participants were randomly assigned to three groups: multi-domain CogTr, single-domain CogTr, and a wait-list control group. Twenty-four sessions of CogTr were administrated to the intervention groups over a three-month period. Six months later, three booster training sessions were offered to 60% of the initial training participants. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS, Form A), the Color Word Stroop test (CWST), the Visual Reasoning test and the Trail Making test (TMT) were used to assess cognitive function.

Results
Multi-domain CogTr produced statistically significant training effects on RBANS, visual reasoning, and immediate and delayed memory, while single-domain CogTr showed training effects on RBANS, visual reasoning, word interference, and visuospatial/constructional score (all P < 0.05). At the 12-month posttest, the multi-domain CogTr showed training effects on RBANS, delayed memory and visual reasoning, while single-domain CogTr only showed effects on word interference. Booster training resulted in effects on RBANS, visual reasoning, time of trail making test, and visuospatial/constructional index score.

Conclusions
Cognitive training can improve memory, visual reasoning, visuospatial construction, attention and neuropsychological status in community-living older people and can help maintain their functioning over time. Multi-domain CogTr enhanced memory proficiency, while single-domain CogTr augmented visuospatial/constructional and attention abilities. Multi-domain CogTr had more advantages in training effect maintenance.

Clinical Trial Registration
Chinese Clinical Trial Registry. Registration number: ChiCTR-TRC-09000732.
The effect of the ratio of standardized ileal digestible lysine to metabolizable energy on growth performance, blood metabolites and hormones of lactating sows
Authors: Xue Lingfeng , Piao Xiangshu , Li Defa , Li Pengfei , Zhang Rongfei , Kim Sung Woo , Dong Bing 
Published: March 2012

Abstract
A total of 335 lactating sows (Landrace × Large White) were used in two experiments to determine the optimum ratio of standardized ileal digestible lysine (SID-Lys) to metabolizable energy (ME) for mixed parity sows during lactation. In Exp. 1, 185 sows (weighing an average of 256.2 ± 6.5 kg and having an average parity of 3.4 ± 0.3) were allocated to one of six experimental diets in a completely randomized block design within parity groups (1, 2, and 3+). The experimental diets were formulated to contain 3.06, 3.16, 3.20, 3.25, 3.30 or 3.40 Mcal/kg of ME and each diet was fed to the sows throughout a 28 day lactation. All diets provided a similar SID-lysine level (0.86%). As a result, the diets provided a SID-Lys:ME ratio of 2.81, 2.72, 2.69, 2.65, 2.61 or 2.53 g/Mcal ME. Sow feed intake was significantly (P < 0.01) affected by the energy content of the diet as well as by sow parity. Using regression analysis, feed intake was shown to be maximized at 3.25, 3.21, 3.21 and 3.21 Mcal/kg of ME for parity 1, 2, 3+ sows and the entire cohort of sows respectively (quadratic; P < 0.01). In addition, the result of feed intake can be expressed as 2.65, 2.69, 2.69 and 2.68 g/Mcal based on analysis of SID-Lys:ME ratio. Litter weight gain was affected by dietary treatment for parity 3+ sows and the entire cohort (P < 0.01). Based on regression analysis, litter weight gain was maximized at 3.25 and 3.24 Mcal/kg of ME for parity 3+ (quadratic; P < 0.01) and the entire cohort (quadratic; P < 0.01). Similarly, the result of litter weight gain could be expressed as 2.65 and 2.66 g/Mcal of SID-Lys:ME ratio. Therefore, 3.25 Mcal/kg of ME was selected for Exp. 2 in which 150 sows (weighing 254.6 ± 7.3 kg and having an average parity of 3.4 ± 0.4) were allocated to one of five treatments in a completely randomized block design within parity (1, 2, and 3+). The experimental diets were formulated to contain 2.1, 2.4, 2.7, 3.0 or 3.3 g/Mcal of SID-Lys:ME ratio with all diets providing 3.25 Mcal/kg of ME. The diets were fed to the sows throughout a 28 day lactation. Sow body weight loss was affected by dietary treatment (parity 3+ sows, P = 0.02; entire cohort, P < 0.01) and by sow parity (P < 0.01). Litter weight at weaning and litter weight gain were affected by dietary treatment for parity 1, 2, 3+ sows and the entire cohort (P < 0.01) as well as by sow parity (P < 0.01). Plasma urea nitrogen (P < 0.01), creatinine (P < 0.01) and non-esterifide fatty acids (P = 0.04) were decreased as the SID-Lys:ME ratio of the diet increased. Insulin-like growth factor-1 (P = 0.02), estradiol (P < 0.01) and luteinizing hormone (P = 0.02) were increased as the SID-Lys:ME ratio in diet increased. Based on a broken-line model, the estimated SID-Lys:ME ratio to maximize litter weight gain was estimated to be 3.05 g/Mcal.
Funding Oncology Clinical Trials: Are Cooperative Group Trials Sustainable?
Authors: Seow Hsien-Yeang , Whelan Patrick , Levine Mark N. , Cowan Kathryn , Lysakowski Barbara , Kowaleski Brenda , Snider Anne , Xu Rebecca Y. , Arnold Andrew 
Published: March 2012

Purpose Many oncology clinical trials departments (CTDs) are in serious fiscal deficit and their sustainability is in jeopardy. This study investigates whether the payment models used to fund industry versus cooperative group trials contribute to the fiscal deficit of a CTD. Methods We examined the lifetime costs of all cooperative group and industry trials activated in the CTD of a cancer center between 2007 and 2011. A trial's lifetime is defined as being from the date the first patient was accrued until the last patient's actual or projected final follow-up visit. For each trial, we calculated the lifetime monthly net income, which was defined as monthly revenue minus monthly costs. Data sources included study protocols, trial budgets, and accrual data. Results Of the 97 trials analyzed, 64 (66%) were cooperative group trials. The pattern of lifetime net income for cooperative group trials has a positive peak during patient accrual followed by a negative trough during follow-up. In contrast, the pattern for industry trials resembled an “l” shape. The patterns reflect the differing payment models: upfront lump-sum payments (cooperative group) versus milestone payments (industry). Conclusion The negative trough in the lifetime net income of a cooperative group trial occurs because follow-up costs are typically not funded or are underfunded. CTDs accrue more patients in new trials to offset that deficit. The CTD uses revenue from accrual to existing trials to cross-subsidize past trials in follow-up. As the number of patients on follow-up increases, the fiscal deficit grows larger each year, perpetuating the cycle.
Marked, Homogeneous, and Early [18F]Fluorodeoxyglucose–Positron Emission Tomography Responses to Vemurafenib in BRAF-Mutant Advanced Melanoma
Authors: McArthur Grant A. , Puzanov Igor , Amaravadi Ravi , Ribas Antoni , Chapman Paul , Kim Kevin B. , Sosman Jeffrey A. , Lee Richard J. , Nolop Keith , Flaherty Keith T. , Callahan Jason , Hicks Rodney J. 
Published: March 2012

Purpose Imaging with [18F]fluorodeoxyglucose (FDG) –positron emission tomography (PET) allows early recognition of a response to agents that target key driver mutations in human cancer. We aimed to determine the metabolic response rate to vemurafenib in patients with advanced BRAF-mutant melanoma. Patients and Methods Baseline and day 15 FDG-PET was evaluated in 31 patients with advanced melanoma treated in a phase I study of dose escalation of vemurafenib (PLX06-02), which included four patients treated at subtherapeutic doses and 24 patients treated at 960 mg twice a day, which is the maximum-tolerated dose of vemurafenib. Results All 27 patients treated at potentially therapeutic levels had at least a partial metabolic response, and three patients achieved a complete metabolic response. In the 27 patients, there was an 80% ± 3% reduction in the maximum standardized uptake value (SUVmax) of target lesions and an 87% ± 3% decrease in the percentage of injected dose (%ID) in all identified disease sites. There was a positive correlation between %ID in all identified disease and target-lesion SUVmax (r2 = 0.66; P < .001) that indicated a significant homogeneity of the response between lesions in individual patients. Although no relationship was found between the reduction in target lesion SUVmax and best response according to RECIST (Response Evaluation Criteria in Solid Tumors), there was a trend for patients with greater reductions in uptake of FDG to have longer progression-free survival. Conclusion FDG-PET is a useful marker of an early biologic response to vemurafenib. Little variability in PET response was found between lesions in individual patients, which suggested minimal intrapatient molecular heterogeneity. FDG-PET is a useful tool for the evaluation of the biologic impact of inhibiting mutant BRAF and may allow for the more effective development of novel agents.
Impact of Age and Comorbidity on Non–Small-Cell Lung Cancer Treatment in Older Veterans
Authors: Wang Sunny , Wong Melisa L. , Hamilton Nathan , Davoren J. Ben , Jahan Thierry M. , Walter Louise C. 
Published: March 2012

Purpose Because comorbidity affects cancer treatment outcomes, guidelines recommend considering comorbidity when making treatment decisions in older patients with lung cancer. Yet, it is unclear whether treatment is targeted to healthier older adults who might reasonably benefit. Patients and Methods Receipt of first-line guideline-recommended treatment was assessed for 20,511 veterans age ≥ 65 years with non–small-cell lung cancer (NSCLC) in the Veterans Affairs (VA) Central Cancer Registry from 2003 to 2008. Patients were stratified by age (65 to 74, 75 to 84, ≥ 85 years), Charlson comorbidity index score (0, 1 to 3, ≥ 4), and American Joint Committee on Cancer stage (I to II, IIIA to IIIB, IIIB with malignant effusion to IV). Comorbidity and patient characteristics were obtained from VA claims and registry data. Multivariate analysis identified predictors of receipt of guideline-recommended treatment. Results In all, 51% of patients with local, 35% with regional, and 27% with metastatic disease received guideline-recommended treatment. Treatment rates decreased more with advancing age than with worsening comorbidity for all stages, such that older patients with no comorbidity had lower rates than younger patients with severe comorbidity. For example, 50% of patients with local disease age 75 to 84 years with no comorbidity received surgery compared with 57% of patients age 65 to 74 years with severe comorbidity (P < .001). In multivariate analysis, age and histology remained strong negative predictors of treatment for all stages, whereas comorbidity and nonclinical factors had a minor effect. Conclusion Advancing age is a much stronger negative predictor of treatment receipt among older veterans with NSCLC than comorbidity. Individualized decisions that go beyond age and include comorbidity are needed to better target NSCLC treatments to older patients who may reasonably benefit.
Epidemiology and Diagnosis of Health Care–Associated Infections in the NICU
Authors: Polin Richard A. , Denson Susan , Brady Michael T. ,   the COMMITTEE ON FETUS AND NEWBORN,   the COMMITTEE ON INFECTIOUS DISEASES, Papile Lu-Ann , Baley Jill E. , Carlo Waldemar A. , Cummings James J. , Kumar Praveen , Polin Richard A. , Tan Rosemarie C. , Watterberg Kristi L. , Byington Carrie L. , Davies H. Dele , Edwards Kathryn M. , Glode Mary P. , Jackson Mary Anne , Keyserling Harry L. , Maldonado Yvonne A. , Murray Dennis L. , Orenstein Walter A. , Schutze Gordon E. , Willoughby Rodney E. , Zaoutis Theoklis E. 
Published: March 2012

This Technical Report was reaffirmed March 2023.
Health care−associated infections in the NICU are a major clinical problem resulting in increased morbidity and mortality, prolonged length of hospital stays, and increased medical costs. Neonates are at high risk for health care−associated infections because of impaired host defense mechanisms, limited amounts of protective endogenous flora on skin and mucosal surfaces at time of birth, reduced barrier function of neonatal skin, the use of invasive procedures and devices, and frequent exposure to broad-spectrum antibiotics. This statement will review the epidemiology and diagnosis of health care−associated infections in newborn infants.
Dynamic nanoscale in situ TEM tribology
Authors: Lockwood A J , Anantheshwara K , Bobji M S , Inkson B J 
Published: March 2012

ABSTRACTNanotribology, the study of friction, wear and lubrication at the nanoscale is an important area of research; however in practice due to the size scale, requires specifically designed tools to characterize nanoscale contacts. We have developed a TEM triboprobe incorporating an advanced nano-positioner with 3D programmable motion inside a transmission electron microscope (TEM) which allows us to selectively apply multiple reciprocating wear cycles to a nanoscale surface, and observe in real-time dynamical changes and the evolution of wear around a sliding nano-contact.Nanoscale cyclic rubbing of an automotive aluminum-silicon alloy processed by focused ion beam (FIB) reveals dynamical surface fragmentation and the generation of nanoscale debris particles. The nanoparticles undergo complex motion as they interact with the sliding nano-contact. Over hundreds of reciprocating cycles, frictional heating leads to a phase separation of the Ga+ ions implanted by FIB forming liquid Ga nano-droplets and liquid bridges. The addition of nanoscale debris particles and liquid droplets dramatically changes the wear dynamics and transforms a 2-body sliding contact into a complex 4-body solid–liquid system exhibiting time-dependent, non-equilibrium kinetic behavior.TEM nanotribology opens up new possibilities for the real-time quantification of cyclic friction, wear and dynamic solid–liquid nano-mechanics, which will have widespread applications in many areas of nano-science and nanotechnology.
Influence of Surface Segregation on the Mechanical Property of Metallic Alloy Nanowires
Authors: Datta Aditi , Duan Zhiyao , Wang Guofeng 
Published: March 2012

ABSTRACTThe influence of surface segregation on the elastic properties of Pt-M (M = Ni, Co, or Fe) nanowires (NWs) are examined by comparing the predicted Young’s moduli of the segregated and non-segregated nanowires using density functional theory (DFT) calculations and the computed stress-strain curves under tensile loading using molecular dynamics (MD) simulation method. The moduli of the segregated NWs were found to be higher than that of the non-segregated ones. It is believed that the surface segregation increases the number of Pt-M bonds across the outermost and second surface layers, and thus enhances the Young’s modulus of the segregated Pt-M nanowires. MD results confirm our DFT results and it is found that onset of plastic deformation could be altered by the surface segregation process, as well.
Upstream Situational Awareness - Comprehensive Events Based Surveillance Solution
Authors: LeBlanc M. , Rees D. 
Published: March 2012

Abstract
For thirty years the U.S. National Aeronautic Space Administration (NASA) has focused much of its efforts on real-time surveillance systems for real-time command and control of space flight, including the space shuttle program and the International Space Station (ISS). During the last several years a new paradigm shift to Commercial off the Shelf (COTS) technology by NASA has led to more rapid system improvements while greatly reducing costs.
COTS real-time surveillance systems architecture is being brought to the upstream oil and gas industry, by a team of technical collaborators instrumental in developing NASA's Mission Control Center in Houston, Texas. Working with major international operators, the team is developing and implementing COTS solutions for exploration and production Real-Time Operations Centers. By combining engineering and command and control systems integration expertise from the aerospace industry with reservoir, deepwater, drilling and production workflow skills and experience, cost effective smart solutions for situational awareness for the oil and gas industry can now be delivered.
Events in 2010 in the deepwater Gulf of Mexico cast a bright spotlight on the need for better understanding and monitoring of reservoir conditions, drilling and production activity, and decision making. Partly in response to these events, this unique integrated alliance team of vendors and proven applications has been formed to offer events-based surveillance, and complex events processing in real-time drilling and production environments.
Inadequate Situational Awareness (SA) has been identified as one of the primary factors in accidents attributed to human error, and is especially important in work domains where the information flow can be quite high and poor decisions may lead to serious consequences. Having complete, accurate and up-to-the-minute SA is essential where the burdens of technological and situational complexity on the human decision-maker are a concern.
Enhancing Production, Reservoir Monitoring, and Joint Venture Development Decisions with a Production Data Center Solution
Authors: Allen Mark , Smith David M 
Published: March 2012

Abstract
Tullow Oil is an independent E&P company with a portfolio of operated and non-operated assets predominantly located across sub-Saharan Africa. The Production and Reservoir Engineering team in Cape Town monitors non-operated production and evaluates Joint Venture (JV) development opportunities for these assets. In 2010 the team initiated a data consolidation project, the objectives of which were to quality control the incoming production data, provide engineering and management teams with easier access to current reservoir and field performance parameters, and reduce engineers' time spent on raw data manipulation. A Production Data Center (PDC) solution would improve the accuracy of data and information in reservoir and production models, thereby improving decision making and asset management.
The PDC solution, successfully implemented in February 2011, automates production data gathering from the JV daily and monthly production reports, assists with data validation, provides a standard data terminology and structure across the portfolio, and links with the corporate finance and reserves systems.