bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stage Shift in Psa-detected Prostate Cancers – Effect Modification by Gleason Score
Authors: Pashayan Nora , Pharoah Paul , Neal David E , Hamdy Freddie , Donovan Jenny , Martin Richard M , Greenberg David , Duffy Stephen W 
Published: June 2009

Objective This paper aims to investigate whether the stage shift (where more cancers are detected at an earlier stage) in prostate-specific antigen (PSA)-detected cancers differs by Gleason score. Methods Between 2002 and 2005, 1514 men aged 50–69 years were identified with prostate cancer following community-based PSA testing as part of the ProtecT study. In the same period, 2021 men aged 50–69 years with clinically diagnosed prostate cancer were registered at a population-based cancer registry in the East of England. Using logistic regression analysis and controlling for age, the odds ratio (OR) for advanced stage (TNM stage T3 and above) prostate cancer among the PSA-detected group was compared with the clinically diagnosed tumours. The evidence that stage shift differs by Gleason score was assessed using the likelihood ratio test for interaction. Results Advanced stage disease among the PSA-detected cancers was less common than among the clinically detected cancers (OR = 0.47, 95% CI 0.39–0.56). PSA-detected tumours had a substantial shift to earlier-stage disease where the Gleason score was <7 (OR = 0.52; 95% CI 0.36–0.77, P < 0.001) but showed no such shift where the Gleason score was 7 or more (OR = 0.84; 95% CI 0.66–1.07, P = 0.1). There was evidence of interaction between detection mode and Gleason score ( P = 0.03). Conclusion The observed stage shift could be partially explained by length bias or overdiagnosis. These findings may have implications on understanding pathways of prostate cancer progression and on identifying potential targets for screening, pending further investigation of complexities of associations between PSA testing, Gleason score, and stage.
Femoral lengthening with the Intramedullary Skeletal Kinetic Distractor
Authors: Simpson A. H. W. R. , Shalaby H. , Keenan G. 
Published: June 2009

Femoral lengthening using the Intramedullary Skeletal Kinetic Distractor is a new technique. However, with intramedullary distraction the surgeon has less control over the lengthening process. Therefore, 33 femora lengthened with this device were assessed to evaluate the effect of operative variables under the surgeon’s control on the course of lengthening. The desired lengthening was achieved in 32 of 33 limbs. Problems encountered included difficulty in achieving length in eight femora (24%) and uncontrolled lengthening in seven (21%). Uncontrolled lengthening was more likely if the osteotomy was placed with less than 80 mm of the thick portion of the nail in the distal fragment (p = 0.052), and a failure to lengthen was more likely if there was over 125 mm in the distal fragment (p = 0.008). The latter problem was reduced with over-reaming by 2.5 mm to 3 mm. Previous intramedullary nailing also predisposed to uncontrolled lengthening (p = 0.042), and these patients required less reaming. Using the Intramedullary Skeletal Kinetic Distractor, good outcomes were obtained; problems were minimised by optimising the position of the osteotomy and the amount of over-reaming performed.
Comparison of polyethylene wear in anatomical and reversed shoulder prostheses
Authors: Terrier A. , Merlini F. , Pioletti D. P. , Farron A. 
Published: June 2009

Wear of polyethylene is associated with aseptic loosening of orthopaedic implants and has been observed in hip and knee prostheses and anatomical implants for the shoulder. The reversed shoulder prostheses have not been assessed as yet. We investigated the volumetric polyethylene wear of the reversed and anatomical Aequalis shoulder prostheses using a mathematical musculoskeletal model. Movement and joint stability were achieved by EMG-controlled activation of the muscles. A non-constant wear factor was considered. Simulated activities of daily living were estimated from in vivo recorded data. After one year of use, the volumetric wear was 8.4 mm3 for the anatomical prosthesis, but 44.6 mm3 for the reversed version. For the anatomical prosthesis the predictions for contact pressure and wear were consistent with biomechanical and clinical data. The abrasive wear of the polyethylene in reversed prostheses should not be underestimated, and further analysis, both experimental and clinical, is required.
Bracing in external rotation for traumatic anterior dislocation of the shoulder
Authors: Finestone A. , Milgrom C. , Radeva-Petrova D. R. , Rath E. , Barchilon V. , Beyth S. , Jaber S. , Safran O. 
Published: June 2009

We undertook a prospective study in 51 male patients aged between 17 and 27 years to ascertain whether immobilisation after primary traumatic anterior dislocation of the shoulder in external rotation was more effective than immobilisation in internal rotation in preventing recurrent dislocation in a physically active population. Of the 51 patients, 24 were randomised to be treated by a traditional brace in internal rotation and 27 were immobilised in external rotation of 15° to 20°. After immobilisation, the patients undertook a standard regime of physiotherapy and were then assessed clinically for evidence of instability. When reviewed at a mean of 33.4 months (24 to 48) ten from the external rotation group (37%) and ten from the internal rotation group (41.7%) had sustained a futher dislocation. There was no statistically significant difference (p = 0.74) between the groups. Our findings show that external rotation bracing may not be as effective as previously reported in preventing recurrent anterior dislocation of the shoulder.
Cadaver bone-tendon graft for xanthomatosis of the tendo Achillis
Authors: Scagnelli R. , Bianco G. , Imarisio D. 
Published: June 2009

We describe a 63-year-old man who had xanthomatosis of the right tendo Achillis. He had undergone excision of the left tendo Achillis 17 years earlier without reconstruction for the same condition. The neurological history and examination were normal. Blood investigations showed hypercholestrolaemia, for which he was being treated with statins. He was referred with pain in the right tendo Achillis and problems with footwear. He was treated by excision of the right tendo Achillis, the xanthomatous nodules and the involved skin, followed by reconstruction with a cadaver bone-tendon graft. At follow-up eight months postoperatively, the scar had healed well. He walked without pain and could wear any type of shoe. Plain radiographs showed that the bone graft had healed. The American Orthopaedic Foot and Ankle Society hindfoot score was 95/100. The patient’s subjective evaluation of the result was very good.
Recurrent club-foot deformity following previous soft-tissue release
Authors: Mehrafshan M. , Rampal V. , Seringe R. , Wicart P. 
Published: June 2009

The results of further soft-tissue release of 79 feet in 60 children with recurrent idiopathic congenital talipes equinovarus were evaluated. The mean age of the children at the time of re-operation was 5.8 years (15 months to 14.5 years). Soft-tissue release was performed in all 79 feet and combined with distal calcaneal excision in 52 feet. The mean follow-up was 12 years (4 to 32). At the latest follow-up the result was excellent or good in 61 feet (77%) according to the Ghanem and Seringe scoring system. The results was considered as fair in 14 feet (18%), all of whom had functional problems and eight had anatomical abnormalities. Four feet (5%) were graded as poor on both functional and anatomical grounds. The results were independent of the age at which revision was undertaken.
Functional Impairments and Caregiver Depressive Symptoms in the Context of Brain Tumour and Other Cancers: A Mediating Effect of Strain
Authors: Ownsworth Tamara , Henderson Laura , Chambers Suzanne , Shum David 
Published: June 2009

AbstractThis study aimed to examine the associations among functional impairments, strain and depressive symptoms for caregivers of individuals with brain tumour and other cancers. Sixty-three caregivers (71% female) of individuals with brain tumour (n = 27) and other cancers (n = 36) were recruited from community services. Participants rated their level of depressive symptoms and strain and the functional impairments of the individual with cancer. Overall, approximately 25% of the total caregiver sample was in the clinical range for depressive symptoms. For caregivers of individuals with brain tumour, strain was significantly related to depressive symptoms (r = .57) and the individual's functional impairments (r = –.58); however, level of depressive symptoms was not significantly related to functional impairments (p > .05). For caregivers of individuals with other cancer, level of depressive symptoms was significantly correlated with strain (r = .50) and their relatives' degree of cognitive, interpersonal and emotional difficulties (r = –.36–.46), but not with activities of daily living (p > .05). In a multivariate analysis involving all the caregivers, strain predicted depressive symptoms (R2 = .32, p < .001) after controlling for gender and cancer type. In addition, strain was found to significantly mediate the effects of the interpersonal and emotional difficulties of individuals with cancer on caregiver depressive symptoms. Overall, these findings highlight the need to develop and evaluate strategies for alleviating the role strain associated with supporting individuals with cancer.
Does Apolipoprotein E Play a Role in Outcome After Severe Traumatic Brain Injury?
Authors: Hodgkinson Adeline , Gillett Lauren , Simpson Grahame K. 
Published: June 2009

AbstractThere is mixed evidence linking adverse outcomes after traumatic brain injury to the presence of the ε4 allele of the apolipoprotein gene (APOE). Further, there has been limited investigation of the role of APOE in populations who have sustained severe brain injuries. In this study, 100 individuals aged 16 to 65 years with a severe to extremely severe traumatic brain injury were recruited prospectively from an inpatient rehabilitation unit. APOE genotypes were determined, and demographic and clinical data were collected by blind assessors at 6 months postinjury. Sixty-nine participants who were divided into an acute (less than 12 months postinjury) and chronic (greater than 12 months) groups also completed neuropsychological assessments testing various domains of memory, attention and problem-solving at follow-up. No significant differences in injury severity, cognitive or functional outcome were found between individuals with the ε4 allele and those without at either time postinjury. This finding is consistent with other recent data that has questioned the role of APOE status as a factor in recovery from TBI.
Hypoxic Brain Injury Following Heroin Overdose
Authors: O'Brien Patricia , Todd Jenny 
Published: June 2009

AbstractHypoxic brain injury is an under-recognised consequence of heroin overdose. This article documents the disability experienced by 10 people with hypoxic brain injuries following heroin overdose who presented in the 2-year period July 1997 to June 1999 at the Royal Talbot Rehabilitation Centre, a brain injury rehabilitation facility in Melbourne, Australia. Medical histories of these clients were reviewed and follow-up interviews were conducted between 2 and 4 years postinjury. Measures included the Functional Independence Measure (FIM) and the Community Integration Questionnaire (CIQ). The results showed that there were significant and enduring consequences for most of the 10 participants. At follow-up two participants had died from subsequent overdose, three required support to live in the community and one lived in an aged care facility. Only one participant was able to return to work. Cognitive problems were present in most of the group and problem solving and social interaction difficulties were the most commonly recorded problems. Three cases are described in detail to highlight some of the significant issues identified in this sample. Implications for the rehabilitation of people with brain injury following heroin overdose are discussed.
Training Communication Partners of People With Traumatic Brain Injury: Reporting the Protocol for a Clinical Trial
Authors: Togher Leanne , McDonald Skye , Tate Robyn , Power Emma , Rietdijk Rachel 
Published: June 2009

AbstractThis article reports on the design of a three-arm, nonrandomised controlled trial of interventions targeting social communication skills following traumatic brain injury (TBI) in adult participants. People with severe TBI were allocated to one of the three groups: the TBI group, where only the person with TBI was trained, the JOINT group where both the everyday communication partner (ECP) and the person with TBI were trained together, and a delayed treatment control condition. The trial is comparing whether including everyday communication partners in the training process provide additional benefit when compared to training the person with TBI alone; and additionally, whether training the person with TBI alone is more effective than no training. A range of primary and secondary outcome measures will be used to evaluate outcomes. Publishing the protocol prior to the results of the trial being available has several important benefits (Godlee, 2001). The original hypotheses and intentions of the research are made explicit to ensure that the process of conducting this clinical trial is transparent to readers, and so that comments may be made before results are finalised. It provides the opportunity to outline a detailed description of this intervention and methodology, or to acknowledge changes to methodology, which may assist with eventual clinical application of the intervention. This article also informs the research community of the work that is underway to promote opportunities for collaboration and reduce unnecessary duplication of research. The protocol for this trial has previously been registered on Current Controlled Trials (http://www.controlled-trials.com/ISRCTN57815281).
Petersen plane arrangements and a surface with multiple 7-secants
Authors: Abo Hirotachi , Kley Holger P. , Peterson Chris 
Published: June 2009

Abstract
We study configurations of 2-planes in that are combinatorially described by the Petersen graph. We discuss conditions for configurations to be locally Cohen–Macaulay and describe the Hilbert scheme of such arrangements. An analysis of the homogeneous ideals of these configurations leads, via linkage, to a class of smooth, general type surfaces in . We compute their numerical invariants and show that they have the unusual property that they admit (multiple) 7-secants. Finally, we demonstrate that the construction applied to Petersen arrangements with additional symmetry leads to surfaces with exceptional automorphism groups.
Orientation of the wood polymers in the cell wall of spruce wood fibres
Authors: Stevanic Jasna S. , Salmén Lennart 
Published: June 2009

Abstract
The mechanical and physical properties of wood fibres depend to a large extent on the orientation of the polymers, mainly the cellulose microfibrils, within the supramolecular structure of the cell wall. Under moist conditions, the arrangement within the polymer matrix may play a dominant role for mechanical properties in general and, especially, in the transverse direction. In this context, it is of special interest to determine the orientation of glucomannan and xylan, being the essential components of softwood hemicelluloses, and of lignin in wood fibres. Fourier transform infrared (FTIR) microscopy was used to examine the orientation of the main wood polymers in transversal and longitudinal direction of spruce fibres. We investigated fibres made from a thermomechanical pulp, in which the outer fibre wall layers were removed by mechanical action, and chemically delignified fibres. The polarised FTIR measurements indicated that glucomannan and xylan appear to have a parallel orientation with regard to the orientation of cellulose and, in all probability, an almost parallel orientation with regard to the fibre axis. Lignin was found to be less oriented in the fibre wall, although its arrangement is not fully isotropic. In the longitudinal direction of the fibres, there were no significant changes in the molecular orientation of the studied polymers.
Extractives in bark of different conifer species growing in Pakistan
Authors: Willför Stefan , Ali Mumtaz , Karonen Maarit , Reunanen Markku , Arfan Mohammad , Harlamow Reija 
Published: June 2009

AbstractThe amount and composition of lipophilic and hydrophilic extractives, including proanthocyanidins, has been analysed as a first screening in the bark of six Pakistani coniferous tree species, namelyPinus wallichiana,Pinus roxburghii,Pinus gerardiana,Abies pindrow,Taxus fuanaandCedrus deodara. The predominant lipophilic extractives were common fatty and resin acids, fatty alcohols and sterols. In all bark samples, short-chain fatty acids were more abundant than long-chain fatty acids. Generally, the amount of free fatty acids was also larger than the amount of triglycerides. Oleic acid was the most common fatty acid, except inC. deodara, where lignoceric acid dominated. The largest amounts of fatty acids and fatty alcohols were found inP. wallichianaandP. gerardiana.P. gerardianacontained an exceptionally large amount of resin acids, approximately 3% of the bark weight, compared to the other species. The amount of free sterols was approximately at the same level or larger than the amount of steryl esters in most samples. In addition to proanthocyanidins, different known lignans, stilbenes, ferulates and flavonoids were generally predominant amongst the hydrophilic extractives. Resveratrol glycoside was abundant inP. wallichiana, whileC. deodaraandP. gerardianacontained large amounts of lignans and lignan derivatives. All bark extracts contained large amounts of proanthocyanidin-related catechin and its derivatives. Furthermore,C. deodaraandP. roxburghiicontained quite large amounts of taxifolin. In particular,P. wallichianaandA. pindroware potential rich sources of proanthocyanidins, representing approximately 16% and 5% of the bark weight, respectively.
TEMPO-mediated oxidation of softwood thermomechanical pulp
Authors: Okita Yusuke , Saito Tsuguyuki , Isogai Akira 
Published: June 2009

AbstractA softwood thermomechanical pulp (TMP) was suspended in water and oxidized with sodium hypochlorite and catalytic amounts of sodium bromide and 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO) at pH 10. When the NaClO addition levels were 20–26 mmol g-1of the TMP, the yields of water-insoluble TEMPO-oxidized TMPs fractions were approximately 40%. Sugar composition and other analyses revealed that most of the lignin and hemicellulose components in the TMP were removed as water-soluble fractions by the oxidation. Thus, almost pure TEMPO-oxidized celluloses can also be prepared from TMP, although the addition levels of NaClO are much higher than for the TEMPO-mediated oxidation of pure celluloses. The water-soluble fractions were analyzed by NMR, showing that polyuronic acids formed from glucomannan and cellulose by oxidation were the main compounds. The water-insoluble fractions of TEMPO-oxidized TMPs prepared with NaClO of 20–26 mmol g-1had carboxylate contents of approximately 1.2 mmol g-1, and had the same cellulose I allomorph and the same crystal widths as in the original TMP. Transparent and highly viscous gels were obtained by disintegration of these TEMPO-oxidized TMPs in water, and the gels consisted of individual nanofibers 4–6 nm in width. Thus, TEMPO-oxidized cellulose nanofibers can also be prepared from TMP.
Non-destructive determination and quantification of diffusion processes in wood by means of neutron imaging
Authors: Mannes David , Sonderegger Walter , Hering Stefan , Lehmann Eberhard , Niemz Peter 
Published: June 2009

Abstract
Diffusion processes in samples of European beech (Fagus sylvatica L.) and Norway spruce (Picea abies [L.] Karst.) were determined and quantified by means of neutron imaging (NI). The experiments were carried out at the neutron imaging facility NEUTRA at the Paul Scherrer Institute in Villigen (Switzerland) using a thermal neutron spectrum. NI is a non-destructive and non-invasive testing method with a very high sensitivity for hydrogen and thus water. Within the scope of this study, diffusion processes in the longitudinal direction were ascertained for solid wood samples exposed to a differentiating climate (dry side/wet side). With NI it was possible to determine the local distribution and consequently the total amount of water absorbed by the samples. The calculated values scarcely differ from those ascertained by weighing (≤3%). The method yields profiles of the water content over the whole sample, thus allowing the local and temporal resolution of diffusion processes within the sample in the main transport direction (longitudinal). On the basis of these profiles, it was possible to calculate the diffusion coefficients along the fibre direction according to Fick's second law.
Characterizing hydro-thermal compression behavior of aspen wood strands
Authors: Zhou Cheng , Smith Gregory D. , Dai Chunping 
Published: June 2009

Abstract
Wood-based composites, such as oriented strand board, are typically manufactured by consolidating mats of resinated wood elements under heat and pressure. During this process, the temperature and moisture content distributions within the mat greatly affect the properties of end products. To improve the fundamental understanding of mat consolidation during hot-pressing, a model is established to investigate the transverse compression behavior of aspen wood strands for a variety of combinations of temperatures (20–200°C) and moisture contents (0–15%). A regression approach is used to obtain the modulus-temperature-moisture relationship. In addition, elevated temperatures and moistures are found to influence the strain function of wood strands, which was previously assumed to be independent of these factors.
Effect of Autoclave Curing on the Compressive Strength and Elastic Modulus of Lightweight Aggregate Concrete
Authors: Wang Her-Yung , Shie Jing-Jie 
Published: June 2009

Abstract
In this study, three types of concrete specimens of different proportions were prepared and mixed at water-to-binder ratios (w/b) of 0.28, 0.32, and 0.40. The specimens were normal-weight concrete (NWC), lightweight sand concrete (LWSC), and lightweight aggregate concrete (LWAC). The specimens then underwent standard curing and autoclaving for 3, 7, 28, and 56 days. Comparisons were made among the specimens in terms of compressive strength and elastic modulus. Experimental results show that after standard curing, the compressive strength of NWC, LWSC, and LWAC at w/b=0.28 were 62.7 MPa (100 %), 54.7 MPa (87 %), and 39.4 MPa (63 %), respectively, indicating that greater particle density aggregates led to better compressive strength. After 56 days of autoclaving, NWC showed the highest compressive strength, followed by LWSC and LWAC. The compressive strength and elastic modulus at Day 28 and Day 56 of autoclaving were close to those at Day 91 and Day 120 of standard curing, respectively; this trend was observed in both NWC and LWSC. The moduli of elasticity for NWC, LWSC, and LWAC at different curing ages were 20.35–33.20, 17.98–24.02, and 10.58–12.95 GPa, respectively, which decreased with increasing lightweight aggregate content in the concrete.