bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine‐needle aspiration cytology of triple‐negative basal‐like breast cancer
Authors: Akashi Shizuka , Kuwabara Hiroko , Kurisu Yoshitaka , Takahashi Yuko , Yasuda Emi , Takeshita Atsushi , Ishizaki Sachie , Tsuji Motomu , Shibayama Yuro 
Published: October 2011

AbstractInvasive breast cancer is divided into luminal A, luminal B, HER2 overexpression, basal‐like (BL) and normal‐like subtypes, among which the BL subtype has the worst prognosis. The purpose of this study was to determine the clinicopathological and cytological characteristics of BL breast cancer (BLBC). Fine‐needle aspiration cytology samples from 17 patients with consecutive BLBC were investigated, and the findings were compared with those of other subtypes (10 cases each) for the following cytomorphological features: necrosis; lymphocyte infiltration; mitotic index; apoptosis; naked nuclei; nuclear/cytoplasmic ratio; nuclear margin, size and pleomorphism; chromatin granularity and density; and nucleolar appearance. Histologically, the BLBCs were heterogeneous, and included medullary carcinoma and metaplastic carcinoma, in addition to invasive ductal carcinoma. Cytologically, high mitotic index, naked nuclei, and irregular nuclear margin were significantly observed when compared with both the luminal A and B subtypes. Large nuclei with nucleoli and lymphocyte infiltration were frequently seen compared with the luminal A and B subtypes, respectively. Squamous nodules were seen in all metaplastic cases, but not in the HER2 overexpression subtype. Lymphocyte infiltration, squamous metaplasia, and nuclear findings such as a high mitotic index, naked or large nuclei, an irregular nuclear margin and the presence of nucleoli, may be clues indicating BLBC. Diagn. Cytopathol. 2013;41:283–287. © 2011 Wiley Periodicals, Inc.
Cytopathologic findings and differential diagnostic considerations of primary clear cell carcinoma of the lung
Authors: Hayashi Toshitetsu , Haba Reiji , Kushida Yoshio , Kadota Kyuichi , Katsuki Naomi , Miyai Yumi , Bando Kenji , Shibuya Shinsuke , Matsunaga Toru , Yokomise Hiroyasu 
Published: October 2011

AbstractPrimary clear cell carcinoma (CLCC) of the lung is an extremely rare disease and is a subtype of large cell carcinoma, according to the World Health Organization (WHO) classification. A case is presented here in which intraoperative squash smears in a 53‐year‐old man revealed sheet and small clusters or tumor cells with prominent nucleoli and fine granular chromatin. Abundant translucent cytoplasm with occasional cytoplasmic vacuoles and intracytoplasmic eosinophilic inclusions was also identified. A cytopathologic diagnosis of a CLCC was suggested. Further evaluation and immunohistochemical studies were conducted on formalin‐fixed, paraffin‐embedded material. Nests of slightly acidophilic clear tumor cells with a prominent cellular membrane and an alveolar growth pattern were identified on H&E sections. Immunohistochemically, the tumor cells showed diffuse and strong membranous staining for CK(AE1/AE3), CK7, and CA19‐9 but were negative for Napsin A, CK20, CDX2, TTF‐1, alpha‐fetoprotein, chromogranin A, synaptophysin, CD10, and CD56. The diagnosis of primary CLCC of the lung was confirmed based on cytopathologic, histopathologic, immunohistochemical results, and a detailed systemic examination to exclude a possible extrapulmonary origin. We report here the cytopathological features of CLCC of the lung with an emphasis on differential diagnostic considerations. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix
Authors: Kuroda Naoto , Wada Yukari , Inoue Kaori , Ohara Masahiko , Mizuno Keiko , Toi Makoto , Tanaka Azusa , Wani Yoji , Yanai Hiroyuki 
Published: October 2011

AbstractLarge cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59‐year‐old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.
The patient‐perceived difficulty in diabetes treatment (PDDT) scale identifies barriers to care
Authors: Tamir Orly , Wainstein Julio , Abadi‐Korek Ifat , Horowitz Einav , Shemer Joshua 
Published: October 2011

AbstractObjectiveThe objective of this study is to describe the design and validation of a newly developed brief, treatment‐focused scale for use with type 1 and type 2‐diabetes, exploring patient‐perceived difficulties that are associated with treatment.MethodsThe content of the construct was derived from consultation with experts, from existing instruments and the literature, as well as from diabetic patients. The original draft was comprised of 11 attributes. Based on an interim analysis, an additional 12th attribute was added. The final scale was tested on 988 diabetic patients from 25 practices in Israel. Respondents also completed a diabetes‐specific quality of life (QoL) questionnaire and indicated their current perceived overall health status.ResultsThe patient‐perceived difficulty of diabetes treatment (PDDT) scale contains 12 items reflecting diabetes‐treatment characteristics: adherence to self‐monitoring of glucose schedule, frequency of self‐monitoring of glucose, adherence to medication administration schedule, frequency of medication administration, multiple number of medications, synchronization between meals and medications, dependence on the medications, pain associated with treatment, diet restrictions, self‐care, multiple healthcare providers, and costs of treatment. Response rate to all attributes was very high. Construct validity was shown by significant correlations between PDDT attributes and diabetes‐specific quality of life (r = 0.31–0.46) and self‐report adherence to recommended treatment (r = 0.14–0.28), as well as between overall perceived difficulty and diabetes‐specific quality of life (r = 0.60). Furthermore, the PDDT items showed discriminant capabilities with respect to known groups of patients.ConclusionsThe PDDT scale is a simple and valid instrument that may assist in identifying potential barriers in adherence to recommended treatments and to new treatment options. Copyright © 2011 John Wiley & Sons, Ltd.
The pubertal‐related decline in cellular proliferation and neurogenesis in the dentate gyrus of male rats is independent of the pubertal rise in gonadal hormones
Authors: Ho Amy , Villacis Allison J. , Svirsky Sarah E. , Foilb Allison R. , Romeo Russell D. 
Published: October 2011

AbstractPubertal development is marked by significant decreases in cellular proliferation and neurogenesis in the dentate gyrus of the hippocampal formation. Although it is unclear what mediates these developmental changes in the dentate gyrus, gonadal hormones have been implicated in modulating many neurobiological processes during puberty and various parameters of neurogenesis in adulthood. Thus, it is possible that the gradual and sustained increase in gonadal hormones experienced during puberty plays a role in these changes in neurogenesis. In this experiments, we first quantified cellular proliferation and neurogenesis using 5‐bromo‐2′‐deoxyuridine (BrdU) and doublecortin (DCX) immunohistochemistry, respectively, in the dentate gyrus of prepubertal (30 d), midpubertal (45 d), and adult (90 d) male rats. We found the decline in BrdU and DCX cell numbers throughout these ages was coincident with increases in their plasma testosterone levels. We next tested whether exposure to the pubertal rise in gonadal hormones was necessary for this decrease in hippocampal neurogenesis to occur. Thus, we examined cellular proliferation and neurogenesis in intact 30 day (prepubertal) and 60‐day‐old (late‐pubertal) rats, as well as 60‐day‐old rats that had previously been gonadectomized or sham‐gonadectomized at 30 days of age. Although we again found the expected decline in BrdU and DCX cell numbers between 30 and 60 days of age in the intact groups, there were no differences among the 60‐day‐old animals, regardless of gonadal status. These data indicate that the pubertal‐related decline in hippocampal cellular proliferation and neurogenesis is independent of the pubertal change in gonadal hormones. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 743–752, 2012
An Unusual (10,3)‐d MOF Material with Nanoscale Helical Cavities and Multifunctionality
Authors: Ibrahim Asiata Omotayo , Zhou Youfu , Jiang Feilong , Chen Lian , Li Xingjun , Xu Wentao , Onawumi Oluyemi O. E. , Odunola Olusegun A. , Hong Maochun 
Published: October 2011

AbstractThe MnII and CuII compounds of 3‐(2‐pyridyl)‐5,6‐diphenyl‐1,2,4‐triazine‐4,4′‐disulfonic acid (H2pdtd) were synthesized and systematically characterized. The metal‐organic framework (MOF) [Mn2(pdtd)2(H2O)4]n·5nH2O (1) was constructed by a solvothermal method preformed at 140 °C with methanol as the solvent, while [Cu(pdtd)(H2O)4]·H2O (2) was obtained by conventional solution chemistry conducted at 80 °C. Crystallographic analysis revealed that 1 has an acentric structure in which the MnII centers are linked via sulfonate groups and chelating nitrogen atoms within the pdtd ligands to give a rare noninterpenetrating (10,3)‐d framework with permanent helical cavities. Consequently, 1 exhibits nonlinear optical (NLO) activity, significant CO2 sorption, and magnetic coupling. In contrast, 2 is a mononuclear complex with coordinated water and lacks functional properties.
Phytosterols in human nutrition: Type, formulation, delivery, and physiological function
Authors: MacKay Dylan S. , Jones Peter J. H. 
Published: October 2011

AbstractPhytosterols are a family of compounds similar to cholesterol which have been shown to lower cholesterol levels when supplemented in the diet. A daily dose of 2–3 g of phytosterols has been shown to reduce LDL‐cholesterol levels by 5–15%. Phytosterol supplementation can be undertaken using phytosterol enriched functional foods or nutraceutical preparations. The type of phytosterol supplemented, such as plant sterol or saturated plant stanol appear to be equally effective in lowering cholesterol levels. Phytosterols, whether in esterified or free form have both been shown to lower cholesterol levels, with esterified phytosterol formulations having a greater number of clinical trials demonstrating efficacy. The functional food or nutraceutical matrix which is used to deliver supplemental phytosterols can significantly affect cholesterol lowering efficacy. Effective cholesterol lowering by phytosterols depends on delivery of phytosterols to the intestine in a form which can compete with cholesterol for absorption. New phytosterol functional food and nutraceuticals products should always be tested to demonstrate adequate delivery of phytosterol dose and effective total and LDL‐cholesterol lowering. Phytosterol products which do not effectively lower cholesterol will negatively impact the perception and use of phytosterols, and must not be allowed on the marketplace.
Validation of a method for the analysis of phytosterols in sunflower seeds
Authors: Fernández‐Cuesta Álvaro , Aguirre‐González Marta R. , Ruiz‐Méndez Maria V. , Velasco Leonardo 
Published: October 2011

AbstractPhytosterols are natural compounds that contribute to lower serum cholesterol in humans. Sunflower seeds and oils are rich sources of phytosterols. Breeding for phytosterol content in sunflower has been scarce thus far, mainly because of the lack of analytical methods suitable for use in plant breeding. The objective of this research was to validate a method for the analysis of phytosterols in small seed samples of sunflower. Samples consisting of six seeds were analyzed for phytosterol content in a set of 87 inbred lines using a method adapted to small samples. The accuracy of the method was evaluated through the standard error of the analysis of replicates of ground samples, which was 72.12 mg/kg compared to average values of 1665.3 and 1887.2 mg/kg seed in the samples. Sunflower inbred lines showed ranges of variation from 1426.0 to 4710.0 mg/kg seed and from 2855.2 to 9752.0 mg/kg oil. The method correlated strongly with the conventional method based on the analysis of extracted oils (r = 0.85). The results indicated that analysis of phytosterols on samples consisting of sunflower seeds is an accurate approach for breeding and genetic studies, in which extraction of the seed oil is not feasible.Practical applications: Phytosterols are usually analyzed in extracted oils. However, studies in plant breeding and plant sciences often require a direct analysis of phytosterols in seeds, without previous oil extraction (e.g. large‐scale screening of germplasm in breeding programs or genetic studies). Our results will be useful for plant scientists interested in the analysis of phytosterols in small samples of plant tissues.
One‐Pot Synthesis of 2,7‐Dioxabicyclo[2.2.1]heptanes from Oxoallylsilanes
Authors: Pulido Francisco J. , Barbero Asunción , Abad Raquel 
Published: October 2011

AbstractA one‐pot high‐yielding synthesis of silylated 2,7‐dioxabicyclo[2.2.1]heptanes from oxoallylsilanes is described. The mechanism of this tandem reaction is a sequential epoxidation of the allylsilane moiety and subsequent intramolecular cyclization. This simple protocol allows the synthesis of epoxy‐bridged tetrahydropyrans from allene in two high‐yielding steps: silylcupration of allene (followed by capture of the intermediate cuprate with enones) and treatment of the oxoallylsilanes thus obtained with MCPBA. However, under the same conditions, oxovinylsilanes yielded epoxysilyl ketones in a very stereoselective manner.
Intramolecular Tandem Isomerization–Mannich Reaction as a New Route Towards Aminocyclopentitols
Authors: Cao Hai Thuong , Roisnel Thierry , Grée René 
Published: October 2011

AbstractA new efficient synthetic strategy has been developed to prepare aminocyclopentitols. It is based on an iron‐catalyzed tandem isomerization–Mannich reaction and uses chiral N‐tert‐butanesulfinamide as a chiral auxiliary. This methodology has been applied to the enantiocontrolled synthesis of a mannostatin A analogue, as well as isomers of known fucosidase and glycosidase inhibitors.
Nonlinear Forecasting Using Factor‐Augmented Models
Authors: Giovannetti Bruno Cara 
Published: October 2011

ABSTRACTUsing factors in forecasting exercises reduces the dimensionality of the covariates set and, therefore, allows the forecaster to explore possible nonlinearities in the model. For an American macroeconomic dataset, I present evidence that the employment of nonlinear estimation methods can improve the out‐of‐sample forecasting accuracy for some macroeconomic variables, such as industrial production, employment, and Fed fund rate. Copyright © 2011 John Wiley & Sons, Ltd.
Relationship between changes in body weight and cognitive function in middle‐aged and older women
Authors: Lo Ada H.Y. , Pachana Nancy A. , Byrne Gerard J. , Sachdev Perminder S. , Woodman Richard J. 
Published: October 2011

BackgroundAlthough several longitudinal studies indicate that weight loss precedes dementia in men and women, the relationship between weight changes and cognitive performance is unclear. This study investigated the relationship between changes in adiposity and cognitive function in community‐dwelling women.MethodsData were derived from the Longitudinal Assessment of Women Study, a population‐based study of 511 urban women initially aged 40–79 years. We analyzed data from 334 women who had complete information on demographics, cardiovascular risk factors, medical status, weight, height, and waist‐to‐hip ratio and cognitive scores at baseline and after a mean of 7.45 years of follow‐up. Cognition was assessed at baseline and follow‐up using the Mini Mental State Examination; the Auditory Delayed Index, Visual Delayed Index, and Working Memory Index from the Wechsler Memory Scale, Third Edition; and the Processing Speed Index from the Wechsler Adult Intelligence Scale, Third Edition. Associations were adjusted for age, education, baseline cognitive performance, cardiovascular risk factors, menopausal status, and apolipoprotein E‐4 status.ResultsIn multivariate analysis, both weight gain and loss were associated with poor Visual Delayed Index performance at follow‐up compared with stable weight (β = −4.02 ± 1.57, p = 0.011; β = −6.50 ± 2.39, p = 0.007, respectively). No significant associations were found between body mass index, waist circumference, or waist‐to‐hip ratio and any cognitive domains at follow‐up. Changes in cognitive performance were not associated with changes in adiposity measures.ConclusionWeight loss and weight gain were associated with poor cognitive performance in middle‐aged and older women compared with women with stable weight. Copyright © 2011 John Wiley & Sons, Ltd.
Coupling to a cancer cell‐specific antibody potentiates tumoricidal properties of curcumin
Authors: Langone Phyllis , Debata Priya Ranjan , Dolai Sukanta , Curcio Gina Marie , Inigo Joseph Del Rosario , Raja Krishnaswami , Banerjee Probal 
Published: October 2011

AbstractIn vitro studies have shown that curcumin, a polyphenol from the culinary component turmeric, has strong anticancer properties. However, there is no consensus on its therapeutic effect in human. Our earlier experiments involving implanted murine melanoma B16F10 cells in the neck or brain of syngeneic C57BL6 mice showed that tail vein injection of curcumin blocks formation of lesions and tumor in these mice. However, such treatment was ineffective in eliminating established tumors that already occupied ≤10% of brain volume. Possible reasons include low solubility and rapid metabolism of curcumin in vivo. To increase its efficacy, we have linked curcumin through a cleavable arm to an antibody (Ab) against the melanoma surface antigen Muc18. The antibody‐coupled curcumin was 230‐fold more effective in eliminating B16F10 cells in vitro, and in vivo, it rapidly decimated established, B16F10‐evoked brain tumors, enabling the rescued mice to live normally far beyond 90 days from implantation of cancer cells. In contrast, mice treated with Muc18 Ab alone died of brain tumor within a month. In B16F10 cells, curcumin‐Ab (adduct) treatment caused a dramatic inhibition of NF‐kB: a transcription factor that is constitutively activated in cancer cells. Furthermore, overexpression of NF‐kB in the B16F10 cells blocked adduct‐evoked stimulation of caspase‐3/7 activity. Thus, by suppressing NF‐kB, the curcumin adduct inhibits other downstream tumor‐promoting proteins, thereby eliminating the B16F10 cells. Our study submits a novel yet generally applicable strategy of converting curcumin into a potent anticancer agent and provides a mechanistic framework for its action.
Comparison of permissible source region and multispectral data using efficient bioluminescence tomography method
Authors: Qin Chenghu , Zhu Shouping , Feng Jinchao , Zhong Jianghong , Ma Xibo , Wu Ping , Tian Jie 
Published: October 2011

AbstractAs a novel molecular imaging technology, bioluminescence tomography (BLT) has become an important tool for biomedical research in recent years, which can perform a quantitative reconstruction of an internal light source distribution with the scattered and transmitted bioluminescent signals measured on the external surface of a small animal. However, BLT is severely ill‐posed because of complex photon propagation in the biological tissue and limited boundary measured data with noise. Therefore, sufficient a priori knowledge should be fused for the uniqueness and stability of BLT solution. Permissible source region strategy and spectrally resolved measurements are two kinds of a priori knowledge commonly used in BLT reconstruction. This paper compares their performance with simulation and in vivo heterogeneous mouse experiments. In order to improve the efficiency of large‐scale source restoration, this paper introduces an efficient iterative shrinkage thresholding method that not only has faster convergence rate but also has better reconstruction accuracy than the modified Newton‐type optimization approach. Finally, a discussion of these two kinds of a priori knowledge is given based on the comparison results. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Predicting patient deterioration in youth mental health services: community mental health vs. managed care settings
Authors: Warren Jared S. , Nelson Philip L. , Burlingame Gary M. , Mondragon Sasha A. 
Published: October 2011

AbstractObjective: To examine differences across a community mental health system and a private managed care system in the accuracy of a warning system designed to identify youth at risk for deterioration in mental health services. Design: Longitudinal outcome data from the Youth Outcome Questionnaire (Y‐OQ) were examined using multilevel modeling for 2,310 youth ages 4–17 who received outpatient treatment. Results: The warning system correctly identified 69% of cases that ultimately ended in deterioration in the community mental health setting, compared to 61% in the managed care setting. The overall hit rate (overall accuracy in classifying cases as deteriorators/non‐deteriorators) was the same in the two settings (75%). Conclusions: Results are consistent with previous research demonstrating that patient‐focused warning systems can be reasonably accurate in identifying youth cases at risk for treatment failure. © 2011 Wiley Periodicals, Inc. J Clin Psychol 67:1–17, 2011.
Neighborhood disorder and the sense of personal control: which factors moderate the association?
Authors: Kim Joongbaeck , Conley Meghan E. 
Published: October 2011

AbstractThis study examines whether and how select individual characteristics moderate the relationship between neighborhood disorder and a sense of personal control. Our findings show that neighborhood disorder is associated with a decreased sense of control. However, regression analyses including interaction terms of neighborhood disorder and some individual characteristics show that the negative effect of neighborhood disorder on sense of control is greater among Whites and people with low economic hardship, compared with racial minorities and those with high economic hardship, when neighborhood disorder is high. These results imply that, for Whites and those with low economic hardship, sense of control is more vulnerable to high levels of neighborhood disorder, even though Whites and people with low economic hardship show higher levels of sense of control than their counterparts when neighborhood disorder is low. Our research contributes to a more nuanced understanding of neighborhood disorder and psychological well‐being. © 2011 Wiley Periodicals, Inc.