bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exergames in exercise-based cardiac rehabilitation for patients with heart failure: a systematic review
Authors: Leo Donato Giuseppe , Scalona Emilia , Lopomo Nicola Francesco , Massussi Mauro , Proietti Riccardo 
Published: May 2024

Aim
The aim of this study was to systematically review the current literature on the use of exergames as an exercise-based cardiac rehabilitation intervention for patients with heart failure.

Methods
PubMed, SCOPUS and CINAHL Plus databases were searched from January 2007 to August 2023. Studies considered eligible for inclusion had to report one or more of the following outcomes: functional capacity (e.g. VO2 max), quality of life, mortality, hospital admissions, physical activity level, and engagement/satisfaction of the intervention. Only studies reported in English were included. Two reviewers independently assessed studies for their eligibility.

Results
Two studies (in four reports) were included. Included studies reported only data on functional capacity (6-min walking test) and on physical activity level (accelerometers). Due to the low number of included studies, no meta-analysis was performed, and results were discussed narratively.

Conclusion
Exergames may potentially be a promising tool for exercise-based cardiac rehabilitation in patients with heart failure; however, the low number of included studies was insufficient to drawn proper conclusions. Benefits of exergames compared with traditional interventions could be the possibility of it being delivered at home, reducing some of the barriers that patients with heart failure must face. Further studies are required to assess the efficacy of exergame interventions in patients with heart failure, and to define proper guidelines to deliver exergame interventions in this population.
This systematic review was registered on PROSPERO (CRD42023446948).
Determination of remifentanil in neonatal dried blood spots by liquid chromatography-tandem mass spectrometry
Authors: Trontelj Jurij , Rozman Aleš , Mrhar Aleš 
Published: May 2024

Abstract
Remifentanil is an ultra-short-acting synthetic opioid-class analgesic which might be increasingly used “off-label” as pain management during labour. Side effects in parturients during labour, and in the infant at birth are of particular concern, especially respiratory depression which is concentration-dependent, and can occur at levels as low as 3–5 ng mL–1. The safety of such use, particularly in newborns due to remifentanil placental transfer, has not been fully demonstrated yet, partly due to the lack of a suitable non-invasive analytical method. The aim of our work was to develop a sensitive method to monitor the levels of remifentanil in neonates by a non-invasive sampling of umbi lical cord blood to support efficacy and safety trials. The presented LC-MS method is sensitive enough to reliably quantify remifentanil in just 20 µL of blood at only 0.3 ng mL–1. The dried blood spot sample preparation included solvent extraction with subsequent solid-phase extraction. The method was validated in terms of accuracy, precision, recovery, matrix effect, and stability, and was successfully applied to a small pilot study. The estimated arterial blood concentrations at the time of delivery ranged from 0.2 to 0.3, and up to 0.9 ng mL–1 in neonatal, and maternal samples, respectively.
The potential of three-dimensional printing for pediatric oral solid dosage forms
Authors: Kreft Klemen , Fanous Marina , Möckel Volker 
Published: May 2024

Abstract
Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing accuracy and palatability. This paper explores the potential of 3D printing as a solution to address the challenges and provide tailored doses of medication for each pediatric patient. The technological overview of 3D printing is discussed, highlighting various 3D printing technologies and their suitability for pharmaceutical applications. Several individualization options with the potential to improve adherence are discussed, such as individualized dosage, custom release kinetics, tablet shape, and palatability. To integrate the preparation of 3D printed medication at the point of care, a decentralized manufacturing model is proposed. In this setup, pharmaceutical companies would routinely provide materials and instructions for 3D printing, while specialized compounding centers or hospital pharmacies perform the printing of medication. In addition, clinical opportunities of 3D printing for dose-finding trials are emphasized. On the other hand, current challenges in adequate dosing, regulatory compliance, adherence to quality standards, and maintenance of intellectual property need to be addressed for 3D printing to close the gap in personalized oral medication.
Population pharmacokinetics of ramipril in patients with chronic heart failure: A real-world longitudinal study
Authors: Trobec Katja Čvan , Grabnar Iztok , Trontelj Jurij , Lainščak Mitja , Kos Mojca Kerec 
Published: May 2024

Abstract
In patients with chronic heart failure (CHF), the use of angiotensin-converting enzyme inhibitors, including ramipril, is recommended to reduce the risk of heart failure worsening, hospitalisation, and death. Our aim was to investigate the influence of body composition on the pharmacokinetics of ramipril and its active metabolite ramiprilat and to evaluate the changes in pharmacokinetics after prolonged therapy. Twenty-three patients with CHF who were on regular therapy with ramipril participated at the first study visit ( median age 77 years, 65 % male, and 70 % New York Heart Association Class II); 19 patients attended the second study visit and the median time between the two visits was 8 months. Pharmacokinetics were assessed using a nonlinear mixed-effects parent-metabolite model comprising two compartments for ramipril and one compartment for ramiprilat. The influence of body size and composition was best described by an allometric relationship with fat-free mass. In addition, ramipril clearance was related to patient age and daily ramipril dose, while clearance of ramiprilat was influenced by glome rular filtration rate and daily ramipril dose. There were no clinically relevant changes in the pharmacokinetics of ramipril and ramiprilat between the study visits. Due to the relatively stable pharmacokinetics of ramipril, regular outpatient visits at 6-month intervals seem appropriate to evaluate ramipril therapy.
Installation of Alternative Energy Sources and Equipment in Residential Buildings in Latvia
Authors: Cimbale A. , Amolina I. , Elsts A. , Geipele I. , Zeltins N. 
Published: May 2024

Abstract
At the end of 2019, the EC presented the European Green Deal – a set of policy initiatives with the ultimate goal of making Europe climate-neutral by 2050. This means that all EU member states must reach climate neutrality. Emissions in all sectors shall be substantially reduced to achieve this goal. Most of the energy is produced using fossil fuels, which contributes to climate change, water and air pollution, as well as the depletion of natural resources. Individual and district heating systems, which supply residential buildings with heat and hot water, are responsible for a part of global emissions.
Electricity generation also produces emissions. The EU recognises the mitigation of climate change as one of the main challenges that must be overcome to ensure sustainable development of the European Union, which is why it has defined ambitious goals to promote decarbonisation and is deliberately moving towards the implementation of renewable energy.
This article aims at analysing the opportunity of using renewable energy resources in multi-apartment residential buildings in the context of sustainability.
Is Memory Just a Technical Tool in Modern Fiction? A Look Into the Growth of Time and Memory in Proust and Kafka
Authors: Simuţ Ramona 
Published: May 2024

Abstract
This paper proposes an insight into the emergence of key concepts in modern narratives, especially related to time and memory in the literature of Marcel Proust and Franz Kafka. Knowing that 20th-century prose draws its novelty from its style and writing technique, we will thus argue that one needs to first inquire as to what modern literature entails before scrutinizing such complex and abstract ideas. Thus, the first part of this study is the mise-en-sc
è
ne for later projections on memory as four-dimmensional time in Proust and metaphysical time in Kafka’s work, while in itself it defines, exemplifies, and analyzes the evocation technique that leads to this complementing view of time in these two writers. Coupled with inquiries into the great social and political panorama rendered by war and seconded by the shifts in narrative themes and topics, the props of Modernism are explored. Time and memory are themes that we will debate on while providing a view on the new prosodic procedures such as the abandonment of the linear narrative flow, the breaking up with conventional ideas of unity and coherence of the plot and characters, and the encouragement of ironic and ambiguous juxtapositions that challenge the action’s traditional moral and philosophical meaning.
Intentionality and Adaptability in Family Language Policy
Authors: Pittman Iulia , Glimois Laurene 
Published: May 2024

Abstract
Heritage language maintenance is affected by many different factors. Particularly for families in subtractive bilingual environments, it is crucial to have a well-defined family language policy (FLP). Even with an established FLP, major disruptions and changes, as well as smaller shifts in families’ lives, can significantly affect children’s multilingual development and threaten heritage language maintenance. These shifts can be sudden or gradual. This study focuses on the importance of bringing the need for a FLP into multilingual families’ awareness and explores the challenges of sustaining it. More specifically, this study uses two parents’ reflections regarding their own families’ language policies to gain a better understanding of the challenges and to make recommendations to other families. It is guided by the following questions: To what extent are parents aware of their family’s multilingual habits and policies? How can parents support their children’s heritage language development in the face of significant disruptions or even subtle life changes? Two linguists raising multilingual children in different contexts agreed to become accountability partners to gain a better understanding of their own dynamic situations and support each other to become more intentional in their family multilingual development. Data were collected over a six-month period. Findings suggest that intentionality increased due to the accountability partnership. Furthermore, this study challenged several of the researchers’ assumptions, particularly regarding the amount of heritage language spoken, how transitions affect the family, what it takes for linguistic changes to occur, and the ease of tracking one’s own family’s linguistic habits. This study suggests that having a FLP is not sufficient, but that it requires periodic updating, and changes need to be implemented to match the evolving plan.
An Analysis of the Most Common L1 Interference Grammar, Vocabulary and Syntax Errors of Lithuanian Learners in Written English
Authors: Nangle Benjamin M. , Parreño Jorge López , Nangle Conor M. , Oleškevičienė Giedrė Valūnaitė , Gulbinskienė Dalia 
Published: May 2024

Abstract
The paper describes a study on the most common English mistakes among Lithuanians in written tasks on the topic of business and finance. The study was conducted with high school students and university students, and the effectiveness of error feedback in reducing the occurrence of errors was also examined by comparing 2 written texts of each participant. Grammatical errors related to the use of articles and punctuation were found to be the most common types of errors, and feedback on errors was found to be an effective tool in increasing learner motivation and understanding, reducing common errors but not reducing the most common types of errors. The research showed that detailed, personalized feedback can help minimize mistakes in writing assignments, especially if it can be accessed during or in between tasks. However, it is uncertain whether this method will have long-lasting benefits or if improvements are dependent on continual feedback reference. Participants were advised to keep their error feedback forms and utilize teachers’ feedback as a constant guide for improvement. We plan to utilize data on frequently occurring errors to conduct additional research on tackling and enhancing language errors that have become ingrained, employing various strategies. Based on the findings, directions for future research were identified. In the future we intend to carry out a study, using controlled texts with a pre-determined number of errors in diagnostic testing. This would allow us to more precisely analyse learners’ improvements in the use of given structures, through a more extensive research.
Promoting Multilingual Skills in Children with Autism: Parent and Teacher Perspectives on Teaching ESL
Authors: Mohamed Amr M. , Shaaban Tahany S. 
Published: May 2024

Abstract
Research on autistic children who grow up in multilingual environments remains sparse, despite more than half of the global population being multilingual. Autistic spectrum disorder (ASD) is characterized by severe impairments in communication and language skills. Many ASD parents ask specialists for advice about whether their child should study both languages simultaneously in a bilingual environment. The study investigated the challenges faced by teachers and parents in educating children with ASD in learning English as a Second language (ESL). The study sample consisted of nine parents and five teachers of children with ASD who were interviewed using a qualitative approach. According to the findings of the study, teaching English as a Second Language to children with autism spectrum disorders with visual aids, modeling, and repetition has been shown to be an effective method to enhance the language and social abilities of children with autism. While it is difficult to develop teaching strategies that are effective for children with autism spectrum disorders, teachers have found that these children are extremely proficient in acquiring new languages. Additionally, to ensure successful language learning programs for children with ASD, it is essential that educators and parents collaborate in order to make the programs successful. Moreover, this study demonstrates various methods that educators and parents could use in order to assist children in achieving bilingualism. The study recommends that more research is needed to fully comprehend the difficulties that ESL teachers face when they are trying to teach children with ASD how to learn languages.
The Use of Spanish Light Verb Constructions in the Advocate General’s Opinions of the Court of Justice of the European Union
Authors: Serapinienė Gabija 
Published: May 2024

Abstract
Over the past few decades, increasing attention has been devoted towards the study of formulaic language, both in Lithuania and abroad. It is assumed that stable word combinations, rather than single words, are preferred in speaking and translating processes, which makes this study increasingly relevant. The idea of formulaic language is well reflected by light verb constructions as one of the collocation types, therefore this article aims to describe the use of these constructions in the analytic Spanish language. The article provides a theoretical overview of light verb constructions, their identification using the Sketch Engine computer program, and their usage in a representative-size corpus, compiled from the EUR-Lex database of documents from the original Spanish texts of the Advocate General’s Opinions of the Court of Justice of the European Union. The analysis of the use of Spanish light verb constructions in the analyzed text provided large objective data on their use, revealing the light verb constructions and their patterns typical to administrative Spanish. It has been found that the grammatical meaning of these light verb constructions is mostly represented by the following support verbs: tener, poner, dar, tomar and hacer. In combinations with nouns, these support verbs mark grammatical aspects such as mood, tense, person, and number. The frequent repetition of light verb constructions in the corpus indicates a standardized lexicon within the Spanish administrative language. In general, the high number of light verb constructions in the corpus reveals their importance in analytic Spanish, especially in the administrative legal language of the Advocate General‘s opinions.
A Corpus-Based Study of Dual Pronoun Translation
Authors: Vaičenonienė Jurgita 
Published: May 2024

Abstract
This article aims to answer the following questions: what is the distribution of dual pronouns in original and translated Lithuanian fiction texts; what English language patterns are rendered by Lithuanian dual pronouns; and how Lithuanian dual pronouns are translated into English. In line with the unique items hypothesis, it is hypothesized that dual pronouns, as a characteristic feature of the Lithuanian language, should be less frequent in translations, as English texts do not have an obvious translation stimulus. Corpus based methods were used for data extraction and analysis. Firstly, from the morphologically annotated ORVELIT corpus, all occurrences of pronouns in original and translated fiction were identified, and all dual forms were extracted. Parallel concordances of dual pronoun translations were obtained from the Lithuanian-English Corpus of Prose LECOP and the Parallel Corpus (English-Lithuanian translation direction) using the ParaConc software (Barlow, 2009). The most frequent forms of personal pronouns were chosen for further analysis: mudu, judu and jiedu. It has been found that differently from initial prediction, Lithuanian translations have similar or slightly higher numbers of dual pronouns in comparison to original Lithuanian texts. The data from English-to-Lithuanian translations shows several patterns rendered by dual pronouns, for example, when English plural personal pronouns describe two referents or when a combination of a personal pronoun and another referent is used with the conjunction and. When translating duals from Lithuanian into English, translators choose English plural forms of pronouns or use the formula ‘pronoun + referent/referent + pronoun’. To compensate for the loss of information about the number of referents or their proximity, translators use the number two. In original English texts, unlike in translated English texts, this usage was not frequent or common.
Gambaran Burnout pada Mahasiswa Pekerja Paruh Waktu di Banda Aceh
Authors: Zahra Misfhilatud , Aini Zahratul , Ningsih Ayu Cahya , Nuwansa Riski , Amna Zaujatul 
Published: May 2024

Burnout adalah suatu kondisi kelelahan emosional, depersonalisasi, dan perasaan rendah diri yang disebabkan oleh adanya stres kerja yang berkepanjangan. Sebagian mahasiswa bekerja paruh waktu yang rentan mengalami burnout yang disebabkan kelelahan secara fisik maupun emosional karena bekerja yang pastinya dapat berdampak pada kulilahnya. Adapun yang menjadi tujuan penelitian dilakukan yaitu untuk melihat gambaran burnout pada mahasiswa pekerja paruh waktu di Banda Aceh, yang dilakukan dengan teknik deskriptif. Pengumpulan data dilakukan secara online menggunakan link gform yang berisikan data demografi dan juga Maslach Burnout Inventory sebagai instrumen pengumpulan data penelitian. Berdasarkan data yang diterima hanya 46 sampel yang memenuhi kriteria penelitian sebagai mahasiswa pekerja paruh waktu yang terdiri dari 25 mahasiswa laki-laki dan 21 mahasiswa perempuan, yang dipilih dengan teknik purposive sampling. Secara garis besar hasil temuan penelitian menunjukkan bahwa mahasiswa yang bekerja paruh waktu mengalami burnout yang sangat tinggi. data menunjukkan bahwa sebanyak 91,3 persen mahasiswa pekerja paruh waktu berada pada level burnout tingkat tinggi, sedangkan 8,7 persen lainnya mengalami burnout tingkat sedang. Burnout is a disorder marked by depersonalization, feelings of inferiority, and emotional weariness brought on by extended periods of stress at work. Some part-time students are vulnerable to burnout brought on by the mental and physical exhaustion of their jobs, and this can definitely affect their academic achievement. The research used descriptive methodologies to determine if burnout has been defined in Banda Aceh's part-time working student population. Data collection was carried out online using a Google-form link that containing demographic data and also the Maslach Burnout Inventory as research instrument. Based on the data received, only 46 samples met the research criteria as part-time working students consisting of 25 male students and 21 female students, who were selected using purposive sampling technique. In general, the research findings indicate that students who work part-time have very high levels of burnout; up to 91.3 per cent of these students have high levels of burnout, while the remaining 8.7 per cent have moderate levels of burnout.
النشاط الثقافي لخيرالدين الزركلي1893-1976
Authors: محسن المرسومي ماهر احمد , عبد الجبوري احمد حسين 
Published: May 2024

تعتبر شخصية خيرالدين الزِرِكلي من الشخصيات البارزة التي تركت أثراً واضحاً في الساحة الصحفية والادبية في التاريخ الحديث والمعاصر, حيث كان له دوراً كبيراً في التصدي للفرنسيين بفكرة وقلمة, وعُدّ محرضاً للثورة ضد الفرنسيين ومعارضاً لدخولهم مما ادى ذلك الى مغادرته دمشق متوجهاً الى بلاد الحجاز, ومن هناك تبدأ مرحلة الكفاح والنضال التي عاشها خيرالدين ضد معركة الحياة والاستعمار الذي سيطر على بلاده, اذ عاش متنقلاً في مختلف البلاد العربية, من دمشق الى الحجاز عام 1920, والى امارة شرق الاردن عام 1921, ثم توجه بعد ذلك الى فلسطين ايام صراع العرب الفلسطينيين مع اليهود والبريطانيين.
لم تتوقف اعمال خيرالدين الصحفية والادبية والتاريخية على بالرغم من كثرة اسفاره , فقد ساهم بنشر عدداً من الصحف في فلسطين, والتي كان عبّر فيها عن آرائه, ويعد خيرالدين الزركلي من فحول شعراء عصره , له جولات في الشعر, وله عناية شديدة بتنقيح شعره وتهذيبه, فنظم شعره الذي اتصف بمتانة التعبير, ودقته في تصوير مآسي شعبة ووصف معاناتهم القاسية في ظل الاحتلال الاجنبي وفي رثاء عظام الامة ومشهوريها, وقد دونة تلك الاشعار في ديوانه .
لم تقتصر اعمال خيرالدين على الجانب الصحفي والادبي بل تعدى ذلك الى قيامه بتأليف عدداً من المؤلفات التاريخية فضلاً من موسوعته الاعلام, اقتضت طبيعة البحث تقسيمة على مقدمة واربعة مباحث وخاتمة جاء المبحث الاول بعنوان حياة خيرالدين الزركلي اسمهُ ومولده ونشأته وتعليمة وعملة ورحلاته, والمبحث الثاني مؤلفات خيرالدين الزركلي التاريخية, وتناولت في المبحث الثالث موسوعة الاعلام لخير الدين الزِرِكلي وفي المحث الرابع تناولت ديوان خيرالدين الزِرِكلي, وقد اعتمد البحث على عدد من المصادر التي سلطت الضوء على حياة خيرالدين الزركلي ونشاطه الصحفي والسياسي والثقافي في المناطق التي تنقل فيها في عدد من البلاد العربية, ومنها مؤلفات خيرالدين الزركلي (موسوعة الاعلام) و(شبه الجزيرة العربية في عهد الملك عبد العزيز), وكتاب ابراهيم العلاونة(خيرالدين الزركلي دراسة وتوثيق) و(خيرالدين الزركلي المؤرخ الاديب صاحب كتاب الاعلام) وغيرها من المصادر الاخرى المدونة في قائمة المصادر لهاذا البحث.