bluuebunny/crossref_metadata_2025_split huggingface dataset:
A non-canonical Arp2/3 complex is essential for Plasmodium DNA segregation and transmission of malaria.
Authors: Hentzschel Franziska , Jewanski David , Sokolowski Yvonne , Agarwal Pratika , Kraeft Anna , Hildenbrand Kolja , Dorner Lilian , Singer Mirko , Marti Matthias , Frischknecht Friedrich 
Published: May 2024

Abstract

Plasmodium parasites, the causative agents of malaria, undergo a crucial development within the mosquito vector, initiated by the formation of male and female gametes from gametocytes. Male gametogenesis involves three rapid rounds of endomitosis followed by a single round of DNA segregation and nuclear division during gamete budding. How the cell organises the segregation of eight genomes from a single octoploid nucleus is currently unknown. Here, we discovered an atypical five-subunit Arp2/3 complex in Plasmodium essential for DNA segregation during male gametogenesis. Unlike the canonical seven-subunit Arp2/3 complex found in other eukaryotes, Plasmodium Arp2/3 localizes to endomitotic spindles and interacts with the kinetochores. Disruption of key Arp2/3 subunits or actin polymerization impedes proper DNA segregation, resulting in the formation of sub-haploid gametes and halting transmission. Our work identified an evolutionary divergent Arp2/3 protein complex in malaria parasites that offers novel insights into its function and potential targets for transmission-blocking interventions.
Load transfer mechanism and design strength of hybrid bolted joint with friction- and bearing-type connections
Authors: Chen Yu , Yamaguchi Takashi , Hayashi Gen , Yamauchi Motoshi , Ueno Keita 
Published: May 2024

Abstract

Long slip-critical bolted joints are extensively used in steel- bridge construction to accommodate increasing traffic loads and optimise steel components. However, as the joint length increases, challenges arise owing to interference with secondary members, uneven bolt force distribution leading to premature failure, and reduced serviceability limit strength. Existing design codes incorporate reduction factors based on joint length to address these issues. This study proposes a hybrid bolt joint that combines friction and bearing-type bolted connections to reduce the joint length while maintaining or improving strength . Finite element analysis was used to investigate the interactive effects of bearing and friction connections, load sharing of hybrid connections, component deformation, and reductions in friction and bearing forces. The results show that the hybrid joint exhibits a uniform load distribution among the friction bolts but an uneven bearing force distribution among the bearing bolts, with the foremost bolt experiencing severe friction force loss. An effective correction factor was proposed to account for the reduction in friction and bearing forces. This study defines the serviceability limit state based on bolt shank shear yielding and provides recommendations for the strength assessment and design of hybrid bolted joints (αs Fs + αb Fb). The results contribute to the development of rational compact joints for steel-bridge construction and address the challenges associated with long multi-row bolted joints.
A Comparative Analysis of Convolutional Neural Network and Vision Transformer Embeddings on a Novel Domain-Specific Task
Authors: Mor Nuriel Sahlom 
Published: May 2024

Abstract

The Vision Transformer (ViT) architecture utilized the self attention and transformer architecture originally designed for natural lan guage processing (NLP) enables ViTs to capture global relationships and long-range dependencies within images. The purpose of our study was to compare the performance of embeddings generated by Convolutional Neural Network (CNN) and Vision Transformers (ViT) on a novel domain-specific task which was not presented at any point to the models prior to the process of the embeddings generation. The pretrained CNN model was MobileNetV2, and the pretrained vision transformer was ViT-B16. The accuracy and F score obtained from the embeddings generated by MobileNetV2 were 0.64 and 0.69 respectively. The accuracy and F-score obtained from the embed dings generated by ViT-B16 were 0.81 and 0.79 respectively. Our study suggests that ViT might perform better in unseen domain specific problems which were not presented in the pretraining. ViT utilizing the self-attention mechanisms capture rich and generic visual representations that might gen eralize well to unseen domain specific problems.
Investigation of microstructure and corrosion resistance of silumin after nickel and copper addition
Authors: Suprapto Wahyono , Risonarta Victor Yuardi , Widodo Agung Sugeng 
Published: May 2024

Aluminium whose Silicon as its main alloying element, i.e. Silumin, is widely applied in engineering due to its novel properties. For particular application, e.g. as block engine of seawater vessel, Silumin’s properties must be enhanced, e.g. strength at elevated temperature, hardenability and corrosion resistance. For those purposes, Nickel and Copper is added to Silumin in this work. As a result, Copper addition by 4.1 %wt increases Silumin density by 13.9 % from 2.95 to 3.36 g/cm3, decreases grain size by 35.3 % from 39.4 to 25.5 μm, increases hardness by 178.8 % from 21.66 to 60.38 HR30T and increases the corrosion rate by 24.5 % from 0.354 to 0.441 mmpy. Meanwhile, addition of Nickel by 6.35 %wt increases Silumin density by 14.9 % from 2.95 to 3.39 g/cm3, decreases grain size by 29.7 % from 39.4 to 27.7 μm, increases hardness by 161.8 % from 21.66 to 56.71 HR30T and decreases the corrosion rate by 41.2 % from 0.354 to 0.2211 mmpy.
To investigate the influence of Copper and Nickel addition on Silumin’s microstructure, micrograph is also taken by using an optical microscope and a scanning electron microscope. The micrograph shows dendrite presence only for the case of Copper added Silumin which deleterious for mechanical properties of Silumin. This dendrite is predicted due to slower cooling rate of the cast Silumin after Copper addition. In addition, the needle-like β-precipitate is sharper after Copper addition. This circumstance is responsible for higher hardness increase for the case of Copper addition compared to Nickel addition. The micrograph shows the existence of CuAl2 intermetallic phase. This intermetallic phase is nobler than Aluminium which is responsible for higher galvanic corrosion in Silumin after Copper addition. On the other hand, the dendrite cannot be observed in the case of Silumin after Nickel addition. The intermetallic phases after Nickel addition, i.e. AlxNiy contribute to the hardness increase. These phases also remain stable at elevated temperature which then then contributes to better mechanical properties of Silumin at the elevated temperature
Operational control of the energy performance of a water-tube boiler using intelligent monitoring of operating variables and parameters
Authors: Chamorro Marley Vanegas , Avella Juan Campos , Barrios Fabián García , Ávila Alfonso Moreno , Marriaga Miguel Peña 
Published: May 2024

In this study, an online monitoring system was implemented for the operational control of an industrial-scale steam generation system. The proposed system allows the migration from measuring boiler efficiency under stationary conditions to measuring it under seasonal conditions, providing greater opportunities for improvement in energy performance. For this purpose, a baseline and goal line model of energy consumption as a function of steam production for an operational base period was constructed. The study shows that the steam generation process has a consumption rate of 0.0885 m3/kg, which is associated with boiler technology, fuel quality, insulation condition, heat recovery equipment, among others. In addition, there is evidence of non-production consumption of 41.225 m3/h, which is mainly due to average consumption in non-productive maneuvers such as starting, stopping, and searching for an operating regime in response to changes in steam demand. The correlation between gas consumption and steam generation was 86.4 %, which represents a 13.6 % variability of consumption associated with controllable operational variables with opportunity for adjustment. The monitoring and control of the main operating parameters of the boiler allows an economic savings of 3.13 % in the boiler, which implies a reduction in operating costs of 92,843 USD per year. The analysis of the operational parameters indicates that it is necessary to maintain a feed water temperature higher than 65 °C and a flue gas temperature lower than 214 °C to ensure boiler efficiency higher than 80 %. With the implementation of activities focused on reducing the combustion gas temperature, increasing the feed water temperature, and controlling operational variables, a 9.01 % reduction in the boiler's natural gas consumption was achieved because of the implementation of operational control
Research on the influence of dynamic parameters on the operation process of gantry cranes with assembled structures on the cap of bridge pier to serve installation of Super –T beams
Authors: Bui Thanh Danh , Nguyen Van Cuong , Nguyen Van Vinh 
Published: May 2024

The gantry crane, positioned atop the bridge pier cap for the installation of Super-T girders, is a specialized construction unit within the bridge construction industry. The article presents a summary of research results investigating dynamic parameters and their influence on the operation of gantry cranes with assembled structures on the cap of bridge piers, serving the installation of Super-T beams in two scenarios: lifting with pre-stressed cable and moving with load (Super-T beam). To examine the dynamic parameters affecting the operation of the gantry crane, the authors first constructed a dynamic model. Subsequently, the influential parameters were determined, and the Matlab Simulink software was employed to develop a survey model corresponding to different values of each parameter and under various working conditions of the gantry crane. This process aimed to identify patterns and unfavorable values of these parameters affecting the operation of the gantry crane. The research results revealed that in both scenarios of lifting with pre-stressed cable and moving with a load (loading), factors such as lifting speed (Vn), stiffness of the main steel structure (S3), conversion stiffness of the lifting cable (S1), oscillation mass of the main structure (m3), wind load acting on the beam (Pg2), wind load acting on the main steel structure (Pg1), and stiffness of the hanging cable (S1) significantly influence the operation of the gantry crane. The survey results also indicated reasonable values for these influential factors during the operation of the gantry crane. The obtained research results can serve as a basis for computational design problems and effective utilization of gantry cranes with assembled structures on the cap of bridge piers for the installation of Super-T beams. Through analysis and simulation using Matlab-Simulink software, specific data on cable tension, main structure acceleration, and structural deformation were collected. The results emphasize the importance of limiting the lifting speed to 2 m/min to ensure stability during cable tensioned lifting and restricting the crane's moving speed to 7.85 m/min to maintain safety and performance when moving loads with tensioned cables
Comparison of the accuracy of OES and EDX tests on nickel dissolving in brass casting
Authors: Erwin  , Suprapto Wahyono , Sugiarto  , Setyarini Putu Hadi 
Published: May 2024

Brass alloys contain the dangerous element lead. Material engineering is carried out to reduce the lead element in brass alloys and add nickel elements as a substitute for lead elements by the casting process. The phenomenon analyzed in this study explains comparing the accuracy level of OES and EDX test results on nickel dissolution in brass casting, especially in adding nickel elements. So that researchers can compare the decrease in the percentage of nickel element composition in the OES test results. At the same time, there is an increase in nickel element composition in the EDX test results. The brass dissolution process uses an electric furnace with an initial temperature of 526 °C. Elemental nickel was introduced into brass solution and dissolved elemental nickel at 978 °C for 120 min for a variation of 1 %, 2 %, 3 %, and for 180 min for a variation of 4 %. The composition of alloying elements is tested using OES and EDX. The dissolution process of brass with the addition of nickel elements tested with OES decreased from 1 % nickel elements to 0.650 %, 2 % to 1.630 %, 3 % to 2.046 %, and 4 % to 2.810 %.
Meanwhile, from the EDX test results, there was an increase in the composition of nickel elements from nickel 1 % to 1.41 %, 2 % to 2.57 %, 3 % to 3.41 %, and 4 % to 4.49 %. Brass alloys with nickel elements added decreased due to slag produced during the dissolution process of nickel elements in molten brass from the test results using OES. EDX testing results in an increase in the percentage of nickel elemental composition. The results of the OES test validation of the mechanical properties of adding nickel elements to brass alloys can be considered because the material's strength is still under the reference UNS C89550. This research contribution resulted in an effective and efficient test method with OES to analyze the elemental composition in brass alloys to which nickel elements have been added
Designing PID controller using SSA for interconnected thermal power systems
Authors: Chaisaward Adithep , Ardhan Kittipong , Obma Jagraphon , Sa-ngiamvibool Worawat 
Published: May 2024

This article presents a method of designing an optimal Proportional-Integral-Derivative (PID) controller for Automatic Generation Control (AGC) of a two-area interconnected thermal system. In addition, an application of Salp Swarm Algirithm (SSA) in order to design PID controllers is proposed. A method inspired by salp foraging behavior. The journey of the Salp group in the sea, by random the population of the salp and separated into leader salp and follower salp. The leader moves towards the food source and the rest of the followers follow the salp positioned in front of themselves. The parameters of PID were achieved by trial and error methods by designers. As an interconneted thermal power system with a Governor Deadband (GDB) is nonlinear and dynamic system, the Integral Squared Error (ISE) criterion has been used as objective function to find optimum controller gain. In order to solve this problem, SSA is proposed to concurrently tune PID gains of the PID controllers to minimize frequency deviations and tie-line power deviations by simulation the interconnected thermal power system .Compare of tuning PID controller from each optimization technique SSA and PSO .Simulation results clearly show that the performance of the system after taking SLP into the interconnected thermal power system that tuning by SSA and PSO and the robustness of the optimal PID controllers are superior to the conventional PID controllers in terms of settling time (–10.46 % in area 1, +0.87 % in area 2 and +0.57 % in power tie-line), overshoot (–10.61 % in area 1 and –10.87 % in area 2) that obtain by (SSA) method less value than the value that obtain by (PSO) method and the power tie-line. Integral Absolute Error (IAE) (–0.38 %) that obtain by (SSA) few errors. Comparisons to the tuned with Particle Swarm Optimization (PSO) approaches is also included
Limitations and Innovative Application Methods of Surfactants for
Solubilization of Poorly Water-Soluble Drugs
Authors: Jin Gang , Wang Jie , Xu Jie , Jin Qing , Xue Jian-Fei , Li Lin-Han 
Published: May 2024

Abstract::
Poor solubility of drugs leads to poor bioavailability and therapeutic efficiency. A large
proportion of drugs that are not developed and marketed for use by patients are due to their extremely
low solubility. Therefore, improving the solubility of poorly water-soluble drugs is one of the most
important aspects of the field of drug research. With the continuous development of more and more
formulation techniques and excipient applications, the solubility of poorly water-soluble drugs can be
improved to a certain extent to obtain better pharmacokinetics and pharmacodynamics, including pH
microenvironment regulation technology, inclusion complex, solid dispersion, nanotechnology, and
application of surfactants. However, the most widely used among them is the application of surfactants.
This technique can reduce the surface tension, improve wettability, and have a remarkable
solubilizing ability after forming micelles. However, surfactants have also been found to possess
certain limitations in solubilization. In this review, the factors affecting the solubilization of surfactants
and limiting their application have been summarized from several aspects. These factors include
drugs, additives, and media. Some ideas to solve these application limitations have also been
put forward, which can lay a foundation for the wider application of surfactants in the future.
Plant-derived Molecules as Potent Anti-skin Cancer Agents
Authors: Gupta Babita , Malviya Rishabha , Mishra Prem Shankar , Uniyal Prerna 
Published: May 2024

Abstract:
The skin is the major tissue in the body and serves as a barrier against hazardous substances
and external attacks. The accumulation of these stressful experiences increases skin cancer risk. In
the United States, skin cancer is a serious health issue. There is a lack of medications that can effectively
treat skin malignancies. In addition, the existing medicines all come with harmful side effects.
Consequently, there is an immediate need for skin cancer treatments that have fewer negative effects.
The preventative possible, therapeutic benefits, bioavailability, and structure-activity relationship of
these chosen phytochemicals for the treatment of skin cancer are discussed in the review. Many cancer
treatments have their origins in the ocean, bacteria, or plants. Cutaneous malignant melanoma has
the highest death rate of all skin cancers and is the most aggressive type of the disease. There are several
ways to treat malignant melanoma; however, they all have very poor success rates because of the
emergence of multi-drug resistance. Phytochemicals are an alternate therapy approach that is both
easily accessible and affordable. Plant-derived phytoconstituents offer a promising anti-carcinogenic
potential for tumors connected to the skin because of their widespread acceptability, safety, fewer
side effects, and signal transmission routes that can be targeted in more than one way. Skin malignancies
are a substantial cause of morbidity and death in the modern world, and research on novel phytochemicals
for their potential to prevent and treat skin cancers has increased dramatically as a result.
The antitumor effect of plant-derived medicinal substances can be attributed to several different
mechanisms and routes, including the breakdown of mitochondrial membrane potential. This review
aimed to provide a concise overview of naturally occurring chemical compounds that are currently
utilized in cancer chemotherapies or have demonstrated potential in avoiding melanoma or skin cancer.
The overview encompasses a variety of phytochemicals, such as flavonoids, carotenoids, terpenoids,
selected polyphenols, and crude plant extracts.
Substances led to Psychosis: A Systematic Review
Authors: Karimi Isaac , Pooyanmehr Nioosha 
Published: May 2024

Background
Psychosis is one of the mind-related disorders that has been common in the new generation, and it has an increasing trend. Psychosis is a variable feature of mood that could be a result of substance use, which includes a few psychiatric and neurologic symptoms. Common symptoms of psychoses are delusions, hallucinations, disorganized thinking, grossly disorganized, or abnormal motor behavior. An array of illicit substances and drugs that can lead to psychosis include cannabinoids, cocaine, amphetamines, methamphetamines, alcohol, etc.

Objectives
The main aim of this review was to discover, analyze, and combine the information concerning substances that could potentially cause psychoses.

Methods
We conducted a literature search on the following network databases: PubMed, Scholar, Science Direct, PubChem, Scopus, and Web-Of-Science. We selected 14 studies potentially relevant articles published from 1990 to 2023 for detailed evaluation. The systematic review was done adhering to PRISMA guidelines. We gathered the important primary studies of eligible systematic reviews and collected data on the interventions employed in these studies to comprehend the strategies that were pursued.

Results
Our result indicated that there are a few substances, which include Cannabinoids, Alcohol, Amphetamine, Cocaine, Nicotine, Kratom, Cathinone, etc., that may lead to psychoses with average to high possibility.

Conclusion
Evidence regarding frequently encountered substances that might contribute to psychosis presents an opportunity to develop customized interventions in the form of user-friendly menus aimed at meeting individuals' requirements and urging them to refrain from consumption.
Pengembangan Virtual Tour Fakultas Teknik Universitas Negeri Yogyakarta Menggunakan Foto 360 Derajat
Authors: Haq Annasbiq Ahsanal , Marpanaji Eko , Dewanto Adi 
Published: May 2024

Penelitian pengembangan virtual tour Fakultas Teknik Universitas Negeri Yogyakarta menggunakan foto 360 derajat bertujuan untuk mengembangkan virtual tour menggunakan foto 360 derajat sebagai media tour wilayah Fakultas Teknik Universitas Negeri Yogyakarta, mendeskripsikan unjuk kerja virtual tour, dan mendeskripsikan kelayakan virtual tour tersebut. Penelitian ini menggunakan jenis penelitian dan pengembangan (research and development) atau R&D dengan model pengembangan V-Model. V-Model memiliki tahapan Requirement Analysis & Acceptance Testing, Specification & System Testing, Architecture Design & Integration Testing, Implementation & Unit Testing. Subyek dalam penelitian ini adalah mahasiswa Fakultas Teknik Universitas Negeri Yogyakarta dan masyarakat umum sebanyak 36 responden. Instrumen penelitian yang digunakan untuk mengetahui kelayakan virtual tour terdiri dari black box testing, lembar penilaian untuk ahli media, dan lembar penelitian untuk responden. Hasil penelitian menunjukkan bahwa pengembangan ini menghasilkan sebuah media virtual tour Fakultas Teknik Universitas Negeri Yogyakarta menggunakan foto 360 derajat. Hasil validasi ahli media mendapatkan persentase sebesar 83,59% dan masuk kategori “Sangat Layak”, sementara hasil dari responden mendapatkan persentase sebesar 85,90% dan tergolong “Sangat Layak”. Dapat disimpulkan bahwa media yang dikembangkan ini sudah sangat layak untuk dioperasikan sebagai media virtual tour di Fakultas Teknik Universitas Negeri Yogyakarta.