bluuebunny/crossref_metadata_2025_split huggingface dataset:
Higher education's future
Authors: Mihel George 
Published: May 2010

AbstractTechnology and globalization have the potential to make higher education more affordable and accessible. In practice, however, rising costs limit educational access, and competition threatens the sustainability of many colleges and universities (Grummon, 2009). With the relevance of traditional curricula in question and the demand for alternate delivery methods expanding, many higher learning institutions face a challenge to reinvent themselves (Barnatt, 2008; Grummon, 2009; Lee, Brennan, & Green, 2009).We asked four higher education leaders from demographically and structurally diverse institutions to address the question, “How will colleges and universities serve the global knowledge economy in the coming decades?” Our respondents represent perspectives from multiple educational paradigms—public and private, local and international, for‐profit and nonprofit, brick‐and‐mortar and online.George Mihel, president of Sauk Valley Community College in Illinois, offers a position paper on the need to transform some of higher education’s deep‐rooted institutional traditions. George Miller, chancellor of American InterContinental University, teams with Caroline Molina‐Ray, a University of Phoenix faculty member, to address how higher education can foster both technological competency and critically reflexive thinking. Naana J. S. Opoku‐Agyemang, vice chancellor of the University of Cape Coast in Ghana, offers insight into the unique challenges and accomplishments of higher education in Africa. Finally, Vicki T. Purslow, associate dean of the College of Arts and Sciences at Southern Oregon University, and Christine Cook Florence, a higher education marketing consultant, present a commentary synthesizing the symposium contributions and issuing a call to action for higher education leaders. Together, these diverse perspectives offer a glimpse into the higher education of the future.
Serving the global knowledge economy
Authors: Opoku‐Agyemang Naana J. S. 
Published: May 2010

AbstractTechnology and globalization have the potential to make higher education more affordable and accessible. In practice, however, rising costs limit educational access, and competition threatens the sustainability of many colleges and universities (Grummon, 2009). With the relevance of traditional curricula in question and the demand for alternate delivery methods expanding, many higher learning institutions face a challenge to reinvent themselves (Barnatt, 2008; Grummon, 2009; Lee, Brennan, & Green, 2009).We asked four higher education leaders from demographically and structurally diverse institutions to address the question, “How will colleges and universities serve the global knowledge economy in the coming decades?” Our respondents represent perspectives from multiple educational paradigms—public and private, local and international, for‐profit and nonprofit, brick‐and‐mortar and online.George Mihel, president of Sauk Valley Community College in Illinois, offers a position paper on the need to transform some of higher education’s deep‐rooted institutional traditions. George Miller, chancellor of American InterContinental University, teams with Caroline Molina‐Ray, a University of Phoenix faculty member, to address how higher education can foster both technological competency and critically reflexive thinking. Naana J. S. Opoku‐Agyemang, vice chancellor of the University of Cape Coast in Ghana, offers insight into the unique challenges and accomplishments of higher education in Africa. Finally, Vicki T. Purslow, associate dean of the College of Arts and Sciences at Southern Oregon University, and Christine Cook Florence, a higher education marketing consultant, present a commentary synthesizing the symposium contributions and issuing a call to action for higher education leaders. Together, these diverse perspectives offer a glimpse into the higher education of the future.
Coda
Authors: Purslow Vicki T. , Cook Florence Christine 
Published: May 2010

AbstractTechnology and globalization have the potential to make higher education more affordable and accessible. In practice, however, rising costs limit educational access, and competition threatens the sustainability of many colleges and universities (Grummon, 2009). With the relevance of traditional curricula in question and the demand for alternate delivery methods expanding, many higher learning institutions face a challenge to reinvent themselves (Barnatt, 2008; Grummon, 2009; Lee, Brennan, & Green, 2009).We asked four higher education leaders from demographically and structurally diverse institutions to address the question, “How will colleges and universities serve the global knowledge economy in the coming decades?” Our respondents represent perspectives from multiple educational paradigms—public and private, local and international, for‐profit and nonprofit, brick‐and‐mortar and online.George Mihel, president of Sauk Valley Community College in Illinois, offers a position paper on the need to transform some of higher education’s deep‐rooted institutional traditions. George Miller, chancellor of American InterContinental University, teams with Caroline Molina‐Ray, a University of Phoenix faculty member, to address how higher education can foster both technological competency and critically reflexive thinking. Naana J. S. Opoku‐Agyemang, vice chancellor of the University of Cape Coast in Ghana, offers insight into the unique challenges and accomplishments of higher education in Africa. Finally, Vicki T. Purslow, associate dean of the College of Arts and Sciences at Southern Oregon University, and Christine Cook Florence, a higher education marketing consultant, present a commentary synthesizing the symposium contributions and issuing a call to action for higher education leaders. Together, these diverse perspectives offer a glimpse into the higher education of the future.</
Portal vein thrombosis and liver transplant survival benefit
Authors: Englesbe Michael J. , Schaubel Douglas E. , Cai Shijie , Guidinger Mary K. , Merion Robert M. 
Published: May 2010

Abstract
Portal vein thrombosis (PVT) complicates the liver transplant operation and potentially affects waiting list survival. The implications on calculations of survival benefit, which balance both waiting list and posttransplant survival effects of PVT, have not been determined. The objective of this study is to describe the effect of PVT on the survival benefit of liver transplantation. Using Scientific Registry of Transplant Recipients data on adult liver transplant candidates wait-listed between September 2001 and December 2007, Cox proportional hazard models were fitted to estimate the covariate-adjusted effect of PVT on transplant rate, waiting list survival, and posttransplant survival. We then used sequential stratification to estimate liver transplant survival benefit by cross-classifications defined by Model for End-Stage Liver Disease (MELD) score and PVT status. The prevalence of reported PVT among 22,291 liver transplant recipients was 4.02% (N = 897). PVT was not a predictor of waiting list mortality (hazard ratio = 0.90, P = 0.23) but was a predictor of posttransplant mortality (hazard ratio = 1.32, P = 0.02). Overall, transplant benefit was not significantly different for patients with PVT versus without PVT (P = 0.21), but there was a shift in the benefit curve. Specifically, the threshold for transplant benefit among patients without PVT was MELD score >11 compared to MELD score >13 for patients with PVT. PVT is associated with significantly higher posttransplant mortality but does not affect waiting list mortality. Among patients with low MELD score, PVT is associated with less transplant survival benefit. Clinicians should carefully consider the risks of liver transplantation in clinically stable patients who have PVT. Liver Transpl 16:999-1005, 2010. © 2010 AASLD.
Supramolecular Assembly of Designed α‐Helical Polypeptide‐Based Nanostructures and Luminescent Conjugated Polyelectrolytes
Authors: Wigenius Jens , Björk Per , Hamedi Mahiar , Aili Daniel 
Published: May 2010

AbstractDesigned polypeptides with controllable folding properties are utilized as supramolecular templates for fabrication of ordered nanoscale molecular and fibrous assemblies of LCPs. The properties of the LCPs as well as the three dimensional conformation of the polypeptide‐scaffold determine how the polymers are arranged in the supramolecular construct, which highly affects the properties of the hybrid material. The ability to control the polypeptide conformation and assembly into fibers provides a promising route for tuning the optical properties of LCPs and for fabrication of complex functional supramolecules with well defined structural properties.magnified image
Characterization of Reversible Associations by Sedimentation Velocity with UltraScan
Authors: Demeler Borries , Brookes Emre , Wang Renjing , Schirf Virgil , Kim Chongwoo A. 
Published: May 2010

AbstractWe compare here the utility of sedimentation velocity (SV) to sedimentation equilibrium (SE) analysis for the characterization of reversible systems. Genetic algorithm optimization in UltraScan is used to optimize the model and to obtain solution properties of all components present in the system. We apply our method to synthetic and experimental data, and suggest limits for the accessible kinetic range. We conclude that equilibrium constants obtained from SV and SE analysis are equivalent, but that SV experiments provide better confidence for the Kd, can better account for the presence of contaminants and provide additional information including rate constants and shape parameters.magnified image
Spectral theory and iterative methods for the Maxwell system in nonsmooth domains
Authors: Mitrea Irina , Ott Katharine 
Published: May 2010

AbstractWe study spectral properties of boundary integral operators which naturally arise in the study of the Maxwell system of equations in a Lipschitz domain Ω ⊆ ℝ3. By employing Rellich‐type identities we show that the spectrum of the magnetic dipole boundary integral operator (composed with an appropriate projection) acting on L2(∂Ω) lies in the exterior of a hyperbola whose shape depends only on the Lipschitz constant of Ω. These spectral theory results are then used to construct generalized Neumann series solutions for boundary value problems associated with the Maxwell system and to study their rates of convergence (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Orientation and Dynamics of ZnO Nanorod Liquid Crystals in Electric Fields
Authors: Zorn Matthias , Tahir Muhammad Nawaz , Bergmann Björn , Tremel Wolfgang , Grigoriadis Chris , Floudas George , Zentel Rudolf 
Published: May 2010

AbstractZnO nanorod polymer hybrids (i.e., ZnO nanorods coated with a block copolymer with a short anchor block (dopamine) and a longer solubilizing block of polystyrene (PS)) form liquid crystalline (LC) phases if they are dispersed at high concentration e.g., in a PS oligomer matrix. Due to the high mobility of the low Tg‐matrix the nanorod polymer hybrids show a switching behavior under an applied AC electric field. Hence, the orientation of the nanorod mesogens can be changed from planar (parallel to the substrate) to homeotropic (perpendicular) in full analogy to the switching of low molecular liquid crystals in an electric field. Dielectric measurements show that such a switching is mainly due to the cooperative LC behavior, because the rods themselves exhibit only a very small effective dipole moment. The process can be investigated by polarizing microscopy. SEM images show the orientations of the individual nanorods, which correspond to the Fredericks transition well known for liquid crystals aligned in an electric field. This was the first time such a transition could be visualized by electron microscopy due to the large nanorod mesogens. The observation is interesting to orient nanorods perpendicular to an electrode and can help to improve optoelectronic devices.magnified image
Conformational Properties of Polymer Mushrooms Under Spherical and Cylindrical Confinement
Authors: Wang Rong , Virnau Peter , Binder Kurt 
Published: May 2010

AbstractA coarse grained model of a flexible macromolecule end‐grafted on the inside of a sphere or a cylinder under good solvent conditions is studied by Monte Carlo simulations. For cylindrical confinement, two regimes are found: when the cylinder radiusRexceeds the gyration radiusRgoof the polymer mushroom grafted to a planar surface, a simple scaling description holds. In the opposite case, a non‐monotonic crossover to a cigar‐like quasi‐one‐dimensional structure occurs, and the distributionPe(x) of the free chain end in thex‐direction along the cylinder axis becomes bimodal. Spherical confinement, on the other hand, causes a crossover from dilute to semidilute behavior of the structural properties.magnified image
Fingertip replantation at or beyond the nail base in children
Authors: Shi Dehai , Qi Jian , Li Donghui , Zhu Lei , Jin Wentao , Cai Daozhang 
Published: May 2010

AbstractAlthough success of digital replantations in children has been reported by many authors, the very distal fingertip replantation remains technically demanding. The aim of this article is to review our experience with fingertip replantations at or distal to the nail base in pediatric patients and evaluate the clinical outcomes. From October 2000 to May 2007, 12 pediatric fingertips amputated at or distal to the nail base were replanted. Only one artery was anastomosed for revascularization with or without nerve repair; vein drainage was provided by the controlled bleeding technique. Eleven of the 12 replants (91%) survived; one replant of crushed digit failed. An average of 26 month (range, 6 to 36 months) follow‐up revealed excellent restoration of finger motion and appearance. The regained static 2‐point discrimination (S2PD) sensation was from 3.2 to 5.0 mm (mean, 4.2 mm). Both the parents and the children were satisfied with the final results. In conclusion, fingertip replantation in children allows good functional and esthetical recovery and should be attempted if technically feasible. © 2010 Wiley‐Liss, Inc. Microsurgery 30:380–385, 2010.
Synchronous behaviors of CBP and acetylations of lysine 18 and lysine 23 on histone H3 during porcine oocyte first meiotic division
Authors: Xue Kai , Song Jiazhe , Wei Hengxi , Chen Li , Ma Yufang , Liu Shen , Li Yan , Dai Yunping , Zhao Yaofeng , Li Ning 
Published: May 2010

AbstractAs a transcriptional coactivator and acetyltransferase, CREB‐binding protein (CBP) is widely characterized due to its functions in cell proliferation and development. However, the activities of CBP in oocyte meiosis are not completely clear. Here we showed that the localization and expression of CBP changed regularly with the progression of porcine oocyte meiosis. The emergence of CBP in chromosomal domains is temporally coincident with the establishments of acetylated lysine 18 (AcH3/K18), lysine 23 (AcH3/K23) and dimethylated arginine 17 (dime‐H3/R17) of histone H3 at meiotic stages from germinal vesicle breakdown (GVBD) to metaphase I (MI). Both CBP expression and these three histone modifications persisted to telophase I (TI). When trichostatin A (TSA) was used to enhance histone acetylations in porcine oocytes, we found that hyperacetylations of H3K18 and H3K23 occurred at meiotic stage from GVBD to TI, together with advanced and enhanced expression of CBP in the nucleus. In addition, disturbance of CBP activity by treatment with 2‐Naphthol‐AS‐Ephosphate (KG‐501, a drug targeting the KIX domain of CBP that disrupts the formation of CBP functional complex) led to synchronous decreases of CBP expression, AcH3/K18 and AcH3/K23 in chromosomal domains during oocyte meiosis. Therefore, these results indicate that the synchronous changes of CBP expression, AcH3/K18 and AcH3/K23 occur during porcine oocyte meiosis. Mol. Reprod. Dev. 77: 605–614, 2010. © 2010 Wiley‐Liss, Inc.
Body weight, social competence, and cognitive functioning in survivors of childhood brain tumors
Authors: Schulte Fiona , Bartels Ute , Bouffet Eric , Janzen Laura , Hamilton Jill , Barrera Maru 
Published: May 2010

AbstractBackgroundThe purpose of the following article was to examine: (a) body mass index (BMI) in survivors of childhood brain tumors; (b) the association of BMI with social competence and cognitive functioning; and (c) congruency in reporting of survivors' social competence by the survivors, parents, and teachers.ProcedureFifty‐four survivors of childhood brain tumors (32 males) 8–18 years participated. BMI‐for‐age percentiles and BMI Z‐scores (SDS) were calculated and survivors were categorized as underweight, normal, overweight, or obese, using established criteria. Informants completed measures of social competence and internalizing behaviors. Survivors also completed a test of self‐perception and cognitive functioning (IQ).ResultsSurvivors were more underweight (15% vs. 4%), and less overweight (17% vs. 31%) than population norms (χ2 = 38.62, P < 0.001). Parents perceived lower social competence in survivors that were underweight, had lower verbal IQ, and higher internalizing behaviors (P < 0.05). A significant interaction between BMI‐for‐age and IQ on self‐perception of close friendships suggested that survivors with lower weight and lower IQ perceived having fewer close friendships (P < 0.05). Congruency among the three informants was moderate.ConclusionsSurvivors of childhood brain tumors are at increased risk for underweight. Underweight status is related to lower parent reported social competence and survivors' self‐perception of fewer close friendships in the presence of low IQ. Pediatr Blood Cancer. 2010;55:532–539. © 2010 Wiley‐Liss, Inc.
Co‐ and post‐translational modifications of the 26S proteasome in yeast
Authors: Kikuchi Julia , Iwafune Yuko , Akiyama Tomoko , Okayama Akiko , Nakamura Hiroki , Arakawa Noriaki , Kimura Yayoi , Hirano Hisashi 
Published: May 2010

AbstractThe yeast (Saccharomyces cerevisiae) 26S proteasome consists of the 19S regulatory particle (19S RP) and 20S proteasome subunits. We detected comprehensively co‐ and post‐translational modifications of these subunits using proteomic techniques. First, using MS/MS, we investigated the N‐terminal modifications of three 19S RP subunits, Rpt1, Rpn13, and Rpn15, which had been unclear, and found that the N‐terminus of Rpt1 is not modified, whereas that of Rpn13 and Rpn15 is acetylated. Second, we identified a total of 33 Ser/Thr phosphorylation sites in 15 subunits of the proteasome. The data obtained by us and other groups reveal that the 26S proteasome contains at least 88 phospho‐amino acids including 63 pSer, 23 pThr, and 2 pTyr residues. Dephosphorylation treatment of the 19S RP with λ phosphatase resulted in a 30% decrease in ATPase activity, demonstrating that phosphorylation is involved in the regulation of ATPase activity in the proteasome. Third, we tried to detect glycosylated subunits of the 26S proteasome. However, we identified neither N‐ and O‐linked oligosaccharides nor O‐linked β‐N‐acetylglucosamine in the 19S RP and 20S proteasome subunits. To date, a total of 110 co‐ and post‐translational modifications, including Nα‐acetylation, Nα‐myristoylation, and phosphorylation, in the yeast 26S proteasome have been identified.
Protein interactions with the platelet integrin αIIb regulatory motif
Authors: Raab Markus , Daxecker Heide , Edwards Richard J. , Treumann Achim , Murphy Derek , Moran Niamh 
Published: May 2010

AbstractIntegrins are transmembrane proteins regulating cellular shape, mobility and the cell cycle. A highly conserved signature motif in the cytoplasmic tail of the integrin α‐subunit, KXGFFKR, plays a critical role in regulating integrin function. To date, six proteins have been identified that target this motif of the platelet‐specific integrin αIIbβ3. We employ peptide‐affinity chromatography followed‐up with LC‐MS/MS analysis as well as protein chips to identify new potential regulators of integrin function in platelets and put them into their biological context using information from protein:protein interaction (PPI) databases. Totally, 44 platelet proteins bind with high affinity to an immobilized LAMWKVGFFKR‐peptide. Of these, seven have been reported in the PPI literature as interactors with integrin α‐subunits. 68 recombinant human proteins expressed on the protein chip specifically bind with high affinity to biotin‐tagged α‐integrin cytoplasmic peptides. Two of these proteins are also identified in the peptide‐affinity experiments, one is also found in the PPI databases and a further one is present in the data to all three approaches. Finally, novel short linear interaction motifs are common to a number of proteins identified.
Top‐down analysis of recombinant histone H3 and its methylated analogs by ESI/FT‐ICR mass spectrometry
Authors: Han Jun , Borchers Christoph H. 
Published: May 2010

AbstractDetailed characterization of the amino acid (aa) compositions of recombinant histone H3 (Xenopus laevis) and its Lys‐9 mono‐, di‐, and trimethylated isoforms was carried out by ESI/FT‐ICR‐MS. The measured molecular masses of these four proteins did not agree with those predicted from the published wild‐type histone H3 sequence. Using MS/MS with both collision‐activated dissociation and electron capture dissociation, three aa substitutions (Gly102Ala, Cys110Ala, and Gly111Ala) were unambiguously identified in each protein by protein database searching and de novo peptide tag sequencing. In addition, it was determined through accurate mass measurement and elemental composition generation that Lys‐9, to which the methyl groups are attached, is not in fact a lysine. Instead, it was identified as a chemical analog of lysine – aminoethylcysteine – in the methylated proteins. After incorporation of these three aa substitutions and the aminoethylcysteine into the protein sequences, the re‐calculated molecular masses of four proteins were completely consistent with the measured values within 1 ppm. This work demonstrates the power of top‐down MS for a detailed structural confirmation of recombinant proteins, even without prior information on aa substitutions or modifications.