bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of obesity on postoperative outcomes following surgery for colorectal cancer: analysis of the National Inpatient Sample 2015–2019
Authors: Kazi Tania , McKechnie Tyler , Lee Yung , Alsayari Rehab , Talwar Gaurav , Doumouras Aristithes , Hong Dennis , Eskicioglu Cagla 
Published: June 2024

AbstractBackgroundThe global burden of obesity has reached epidemic proportions, placing great strain on the North American healthcare system. We designed a retrospective cohort database study comparing postoperative morbidity and healthcare resource utilization between patients living with and without obesity undergoing surgery for colorectal cancer.MethodsAdult patients undergoing resection for colorectal cancer were identified from the 2015 to 2019 National Inpatient Sample database. Patients were stratified according to obesity status (i.e., body mass index of 30 kg/m2). Propensity score matching (PSM) with 1:1 nearest‐neighbour matching was performed according to demographic, operative, and hospital characteristics. The primary outcome was postoperative morbidity. Secondary outcomes included system‐specific postoperative complications, postoperative mortality, length of stay, total admission healthcare cost, and post‐discharge disposition. McNemar's and Wilcoxon matched pairs signed rank tests were performed.ResultsAfter PSM, 7565 non‐obese and 7565 obese patients were included. Patients with obesity had a 10% increase in relative risk of overall in‐hospital postoperative morbidity (23.1% versus 25.6%, P = 0.0015) and a $4564 increase in hospitalization cost ($70 248 USD versus $74 812 USD, P = 0.0004). Patients with obesity were more likely to require post‐operative ICU admission (5.0% versus 8.0%, P < 0.0001) and less likely to be discharged home after their index operation (68.3% versus 64.2%, P = 0.0022).ConclusionPatients with obesity undergoing surgery for colorectal cancer may be at an increased risk of in‐hospital postoperative morbidity. They may also be more likely to have increased hospitalization costs, post‐operative ICU admissions, and to not be discharged directly home. Preoperative optimization via weight loss strategies should be further explored.
Systematic review: Patient‐related, microbial, surgical, and histopathological risk factors for endoscopic post‐operative recurrence in patients with Crohn's disease
Authors: Bak Michiel T. J. , Demers Karlijn , Hammoudi Nassim , Allez Matthieu , Silverberg Mark S. , Fuhler Gwenny M. , Parikh Kaushal , Pierik Marieke J. , Stassen Laurents P. S. , van der Woude C. Janneke , Doukas Michail , van Ruler Oddeke , de Vries Annemarie C. 
Published: June 2024

SummaryBackgroundRisk stratification for endoscopic post‐operative recurrence (ePOR) in Crohn's disease (CD) is required to identify patients who would benefit most from initiation of prophylactic medication and intensive monitoring of recurrence.AimsTo assess the current evidence on patient‐related, microbial, surgical and histopathological risk factors for ePOR in patients with CD after ileocolic (re‐)resection.MethodsMultiple online databases (Embase, MEDLINE, Web of Science and Cochrane Library) were searched up to March 2024. Studies with reported associations of patient‐related, microbial, surgical and/or histopathological factors for ePOR (i.e., Rutgeerts’ score ≥i2 or modified Rutgeerts’ score ≥i2a) were included. The risk of bias was assessed with the Newcastle‐Ottawa Scale for observational cohort studies and case‐control studies.ResultsIn total, 47 studies were included (four RCTs, 29 cohort studies, 12 case–control studies, one cross‐sectional study and one individual participant data meta‐analysis) including 6006 patients (median sample size 87 patients [interquartile range 46–170]). Risk of bias assessment revealed a poor quality in 41% of the studies. An association was reported in multiple studies of ePOR with active smoking at and post‐surgery, male sex and prior bowel resection. A heterogeneous association with ePOR was reported for other risk factors included in the current guidelines (penetrating disease, perianal disease, younger age, extensive small bowel disease and presence of granulomas in the resection specimen or myenteric plexitis in the resection margin), and other patient‐related, microbial, surgical and histopathological factors.ConclusionRisk factors for ePOR in international guidelines are not consistently reported as risk factors in current literature except for active smoking and prior bowel resection. To develop evidence‐based, personalised strategies, large prospective studies are warranted to identify risk factors for ePOR. Validation studies of promising (bio)markers are also required.
The paradigm shift: Business associations shaping the discourse on system change
Authors: Waddock Sandra , Henriques Irene , Linnenluecke Martina , Poggioli Nicholas , Böhm Steffen 
Published: June 2024

AbstractThis Agenda 2050 piece is a call to action for management scholars to follow the lead of business associations, foundations, and businesses in studying and understanding the transformative change needed to bring about a more equitable and flourishing world for all living beings—including humans and other‐than‐humans. These entities advocate for a significant paradigm shift in how business is practiced as a way of responding to ‘polycrisis’—the interrelated set of civilization‐threatening crises that includes climate change, social inequality, and biodiversity loss. Yet management scholars lag behind business discourse with issues of sustainability and ecological flourishing, adapting to the type of leadership needed for the future, and understanding the need for system change. We provide four keystone pathways to help scholars shape future discourse in business scholarship, practice, and curricula: 1) structural changes to management education, 2) piloting social impact, 3) development of regenerative business models, and 4) moral, legal, and financial cases for action.
On the prospects of longtermism
Authors: Persson Ingmar , Savulescu Julian 
Published: June 2024

AbstractThis article objects to two arguments that William MacAskill gives in What We Owe the Future in support of optimism about the prospects of longtermism, that is, the prospects of positively influencing the longterm future. First, it grants that he is right that, whereas humans sometimes benefit others as an end, they rarely harm them as an end, but argues that this bias towards positive motivation is counteracted by the fact that it is practically easier to harm than to benefit. For this greater easiness makes it likely both that accidental effects will be harmful rather than beneficial and that the means or side‐effects of the actions people perform with the aim of benefiting themselves and those close to them will tend to be harmful to others. Secondly, while our article agrees with him that values could lock‐in, it contends that the value of longtermism is unlikely to lock in as long as human beings have not been morally enhanced but remain partial in favor of themselves and those near and dear.
GATA2 heterozygosity causes an epigenetic feedback mechanism resulting in myeloid and erythroid dysplasia
Authors: Gioacchino Emanuele , Zhang Wei , Koyunlar Cansu , Zink Joke , de Looper Hans , Gussinklo Kirsten J. , Hoogenboezem Remco , Bosch Dennis , Bindels Eric , Touw Ivo P. , de Pater Emma 
Published: June 2024

SummaryThe transcription factor GATA2 has a pivotal role in haematopoiesis. Heterozygous germline GATA2 mutations result in a syndrome characterized by immunodeficiency, bone marrow failure and predispositions to myelodysplastic syndrome (MDS) and acute myeloid leukaemia. Clinical symptoms in these patients are diverse and mechanisms driving GATA2‐related phenotypes are largely unknown. To explore the impact of GATA2 haploinsufficiency on haematopoiesis, we generated a zebrafish model carrying a heterozygous mutation of gata2b (gata2b+/−), an orthologue of GATA2. Morphological analysis revealed myeloid and erythroid dysplasia in gata2b+/− kidney marrow. Because Gata2b could affect both transcription and chromatin accessibility during lineage differentiation, this was assessed by single‐cell (sc) RNA‐seq and single‐nucleus (sn) ATAC‐seq. Sn‐ATAC‐seq showed that the co‐accessibility between the transcription start site (TSS) and a −3.5–4.1 kb putative enhancer was more robust in gata2b+/− zebrafish HSPCs compared to wild type, increasing gata2b expression and resulting in higher genome‐wide Gata2b motif use in HSPCs. As a result of increased accessibility of the gata2b locus, gata2b+/− chromatin was also more accessible during lineage differentiation. scRNA‐seq data revealed myeloid differentiation defects, that is, impaired cell cycle progression, reduced expression of cebpa and cebpb and increased signatures of ribosome biogenesis. These data also revealed a differentiation delay in erythroid progenitors, aberrant proliferative signatures and down‐regulation of Gata1a, a master regulator of erythropoiesis, which worsened with age. These findings suggest that cell‐intrinsic compensatory mechanisms, needed to obtain normal levels of Gata2b in heterozygous HSPCs to maintain their integrity, result in aberrant lineage differentiation, thereby representing a critical step in the predisposition to MDS.
Decreased extrasynaptic δ‐GABAA receptors in PNN‐associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease
Authors: Zhang Weicong , Liu Tiansheng , Li Jialin , Singh Jaijeet , Chan Andi , Islam Anam , Petrache Alexandra , Peng Yunan , Harvey Kirsten , Ali Afia B. 
Published: June 2024

AbstractBackgroundAlzheimer's disease (AD) is associated with gradual memory loss and anxiety which affects ~75% of AD patients. This study investigated whether AD‐associated anxiety correlated with modulation of extrasynaptic δ‐subunit‐containing GABAA receptors (δ‐GABAARs) in experimental mouse models of AD.Experimental approachWe combined behavioural experimental paradigms to measure cognition performance, and anxiety with neuroanatomy and molecular biology, using familial knock‐in (KI) mouse models of AD that harbour β‐amyloid (Aβ) precursor protein App (AppNL‐F) with or without humanized microtubule‐associated protein tau (MAPT), age‐matched to wild‐type control mice at three different age windows.ResultsAppNL‐F KI and AppNL‐F/MAPT AD models showed a similar magnitude of cognitive decline and elevated magnitude of anxiety correlated with neuroinflammatory hallmarks, including triggering receptor expressed on myeloid cells 2 (TREM2), reactive astrocytes and activated microglia consistent with accumulation of Aβ, tau and down‐regulation of Wnt/β‐catenin signalling compared to aged‐matched WT controls. In both the CA1 region of the hippocampus and dentate gyrus, there was an age‐dependent decline in the expression of δ‐GABAARs selectively expressed in parvalbumin (PV)‐expressing interneurons, encapsulated by perineuronal nets (PNNs) in the AD mouse models compared to WT mice.In vivo positive allosteric modulation of the δ‐GABAARs, using a δ‐selective‐compound DS2, decreased the level of anxiety in the AD mouse models, which was correlated with reduced hallmarks of neuroinflammation, and ‘normalisation’ of the expression of δ‐GABAARs.ConclusionsOur data show that the δ‐GABAARs could potentially be targeted for alleviating symptoms of anxiety, which would greatly improve the quality of life of AD individuals.
A fluvial‐aeolian system in response to aridification during the Late Mesozoic, Junggar Basin, Central Asia
Authors: Guan Xutong , Wu Chaodong , Xu Yan , Jolivet Marc , Xiu Jinlei , Lin Cong 
Published: June 2024

AbstractAridification of Central Asia in the Late Mesozoic led to drastic environmental changes characterized by widespread aeolian deposits. We systematically investigated fluvial‐aeolian deposits in the Middle Jurassic Toutunhe Formation, Upper Jurassic Kalazha Formation, and Lower Cretaceous Tugulu Group in the Junggar Basin to the north of the Tianshan Orogenic Belt via unmanned aerial vehicle‐based photogrammetry, scanning electron microscope, grain‐size analysis, and detrital zircon geochronology. Paludal and deltaic environments transitioned to a fluvial‐aeolian environment from the late Middle Jurassic to the Late Jurassic. Fan delta and incisive braided river deposits accumulated in the earliest Cretaceous and evolved into a lacustrine environment with aeolian deposits in the lakeshore. Aeolian deposits are characterized by moderate‐ to well‐sorted and subangular to subround sandstones with large‐scale, high‐dip cross‐bedding, inversely graded lamination, dominant saltation grains, crescent‐shaped, and dish‐shaped impact structures. Aeolian deposits contain heavy minerals including more ilmenite, zircon, garnet, and, tourmaline and less magnetite and epidote than the fluvial deposits. The preserved aeolian sediments of the Kalazha Formation extend west–east for more than 100 km, suggesting a wide desert area during the latest Jurassic. The detrital zircon age patterns indicate that the provenance of the aeolian deposits was similar to that of coeval fluvial deposits. The cooccurrence of fluvial and aeolian deposits and the similar provenances but orthogonal flow directions indicate that the aeolian deposits were mainly sourced from the nearby fluvial material within the basin. The evolution of the fluvial‐aeolian system responded to a complete base‐level cycle controlled by the aridification and tectonics. Due to decreased sediment supply caused by aridification, the base level rose, leading to the change from braided rivers to meandering rivers, along with the deposition of aeolian sediments. Due to the tectonic reactivation in the Late Jurassic, the base level fell, causing the occurrence of alluvial fans and the expansion of the aeolian sediments. Previous studies revealed that the Tianshan in the Jurassic exhibited low relief. The fluvial‐aeolian system played an important role in maintaining the limited relief in southern Central Asia.
Beyond attachment theory: Indigenous perspectives on the child–caregiver bond from a northwest tribal community
Authors: Waters Sara F. , Richardson Meenakshi , Mills Sara R. , Marris Alvina , Harris Fawn , Parker Myra 
Published: June 2024

AbstractHealthy Indigenous child development is grounded in Indigenous ways of knowing and being. Attachment theory has been influential in understanding the significance of parenting for infant development in Western science but has focused on child–caregiver bonds predominantly within the parent–child dyad. To bring forth Indigenous perspectives regarding understandings of parenting, the attachment bond, and the well‐being of Indigenous children, we conducted semi‐structured interviews with 28 members of a Northwest tribal community (21 female) in spring and summer 2020. Themes included Community caregiving, Family value systems, Bonding, Traditional teachings, and Historical trauma. The need to expand the lens of attachment theory beyond the dyad is clear. Implications for improving the child welfare system and prevention programs within Indigenous communities are discussed.
Robust colored point cloud alignment based on L*a*b* guided and Cauchy kernel
Authors: Wan Teng , Du Shaoyi , Zhang Qiang , Qi Ying , Huang Chunyao , Zeng Wei 
Published: June 2024

AbstractPrecision agriculture benefits from point set registration, which can monitor plant health and growth in real time, promote the precise application of fertilizers and pesticides, and provide technical support for achieving sustainable development of agriculture. In this work, we propose a robust point set registration method for precision agriculture based on L*a*b* color guidance, bidirectional search and Cauchy distribution. First, the L*a*b* color guidance is applied to establish accurate correspondences between agricultural RGB‐D data. Second, the bidirectional nearest neighbor search strategy between point sets improves the reliability of establishing correspondences and broadens the convergence domain of the algorithm. Third, Cauchy distribution is utilized as an energy function for noise suppression, which further improves the robustness of the algorithm in dealing with complex vegetation scenes. Finally, results of ablation and simulation experiments indicate that the proposed registration algorithm can achieve more accurate and robust alignment results than other classic and state‐of‐the‐art point cloud registration algorithms to achieve monitoring and comparison of plant growth.
UReslham: Radar reflectivity inversion for smart agriculture with spatial federated learning over geostationary satellite observations
Authors: Jin Zhengyong , Xu Xiaolong , Bilal Muhammad , Wu Songyu , Lin Huichao 
Published: June 2024

AbstractThe frequent occurrence of severe convective weather has certain adverse effects on the smart agriculture industry. To enhance the prediction of severe convective weather, the inversion model effectively fills radar reflectivity data gaps by leveraging geostationary satellite data, offering more comprehensive and accurate support for meteorological information in smart agriculture systems. Nevertheless, collaborative cross‐regional inversion driven by dispersed radar data faces challenges in efficiency, privacy, and model accuracy. To this end, we employ an U‐shaped residual network with an embedded light hybrid attention mechanism and utilize a federated averaging algorithm for efficient distributed training across multiple devices which could preserve the privacy of data from different locations, thereby improving inversion performance. In addition, to address the unbalanced nature of radar data, a weighted loss function is designed to enhance the model's sensitivity to high radar reflectivity. Experimental results demonstrate that the proposed model exhibits a certain level of improvement in evaluating radar reflectivity inversion performance across different thresholds compared to other models, thus substantiating the superiority of the proposed approach.
Improving equity in diabetes technology use: Voices of youth and their parents
Authors: Perkins Amanda , Hinds Pamela S. , Grundman Jody B. , Meighan Seema , Monaghan Maureen , Streisand Randi , Marks Brynn E. 
Published: June 2024

AbstractAimsThere are marked inequities in clinical outcomes and rates of diabetes technology use among youth with type 1 diabetes (T1D). The quantitative data from our mixed methods cohort study identified significant improvements in glycaemia and quality of life in participants. We aimed to use qualitative methods to provide further insight into our quantitative findings in the setting of underlying health disparities.MethodsFifteen publicly insured, insulin pump‐naïve non‐Hispanic Black youth aged 6–21 years with T1D and baseline haemoglobin A1c (HbA1c) ≥86 mmol/mol (10%) and their parents participated in a mixed methods cohort study. Semi‐structured interviews were conducted separately with parents and youth after completion of 6 months of HCL use. Three topic areas were explored: (1) Experience using HCL, (2) barriers to HCL and (3) facilitators to accessing HCL. Semantic content analysis and consensus coding involving two team members were used to generate themes. Thematic saturation was achieved.ResultsYouth (Medianage 14.9 years, 67% female) and parents (92% female) were interviewed. Youth and their parents reported that access to HCL provides a new outlook on living with T1D, although managing T1D is still hard. They felt that diabetes technology is most helpful for those struggling with management. Participants experienced barriers to access including misconceptions of HCL systems, clinician bias and systemic racism. They suggested these barriers can be overcome by offering diabetes technology education for all people with T1D, increasing awareness of HCL in the community and providing resources to overcome barriers created by social determinants of health.ConclusionsThe voices of historically minoritised youth with suboptimal T1D control and their parents provide important, previously unreported experiences and perspectives on barriers and facilitators to using HCL that will shape interventions to improve equity in access to diabetes technology.
The selective serotonin reuptake inhibitors, sertraline and paroxetine, improve islet beta‐cell mass and function in vitro
Authors: Toczyska Klaudia , Haq Naila , Lyu Zekun , Bewick Gavin , Zhao Min , Rosa Hannah , Starikova Jessica , Liu Bo , Persaud Shanta Jean 
Published: June 2024

AbstractAimsTo investigate the effects of the selective serotonin reuptake inhibitors (SSRIs) sertraline and paroxetine at therapeutically relevant concentrations on beta‐cell mass and function.MethodsViability was quantified in mouse insulinoma (MIN6) beta cells and mouse islets after 48‐h exposure to sertraline (1–10 μM) or paroxetine (0.01–1 μM) using the Trypan blue exclusion test. The effects of therapeutic concentrations of these SSRIs on insulin secretion were determined by static incubation and perifusion experiments, while islet apoptosis was investigated by Caspase‐Glo 3/7 assay, TUNEL staining and quantitative PCR analysis. Finally, proliferation of MIN6 and mouse islet beta cells was assessed by bromodeoxyuridine (BrdU) enzyme‐linked immunosorbent assay and immunofluorescence.ResultsSertraline (0.1–1 μM) and paroxetine (0.01–0.1 μM) were well tolerated by MIN6 beta cells and islets, whereas 10 μM sertraline and 1 μM paroxetine were cytotoxic. Exposure to 1 μM sertraline and 0.1 μM paroxetine significantly potentiated glucose‐stimulated insulin secretion from mouse and human islets. Moreover, they showed protective effects against cytokine‐ and palmitate‐induced apoptosis of islets, they downregulated cytokine‐induced Stat1 and Traf1 mRNA expression, and they significantly increased proliferation of mouse beta cells.ConclusionsOur data demonstrate that sertraline and paroxetine act directly on beta cells to enhance glucose‐stimulated insulin secretion and stimulate beta‐cell mass expansion by increasing proliferation and decreasing apoptosis. These drugs are therefore likely to be appropriate for treating depression in people with type 2 diabetes.
Not following the script: When institutional development is uneven
Authors: Murphy Ryan H 
Published: June 2024

AbstractThree characteristics of developed twenty‐first century countries are high levels of state capacity, democracy, and economic freedom. This article compares countries that lack one of the characteristics with countries that have more even levels of institutional development. Countries which lack democracy use other means to secure political legitimacy, and those without strong states are geographically concentrated in Latin America and eastern Europe. Those without liberalised economic institutions are an idiosyncratic group that have unconventional historical paths. These findings speak to the prospects for development outside the liberal democratic path, the nature of development in the absence of a state, and unexplored determinants of economic freedom.
A project of “impure” enquiry—Williams' historical self‐consciousness
Authors: Fricker Miranda 
Published: June 2024

AbstractBernard Williams’ philosophy is shaped by a distinctive and abiding interest in the borderlands between Philosophy and History. He famously considers moral philosophy, and particularly moral theory, to over‐step the border that marks the real ‘limits’ of the discipline, and in his later work he explicitly advances the idea of doing ‘impure’ philosophy, by which he meant philosophy that mixed itself with history. By examining the complex impression left on Williams’ historical self‐consciousness by his engagements with two very different figures in the history of philosophy, namely Descartes and Wittgenstein, I will explore a number of ways in which philosophy and history are closely intertwined for Williams. This will draw out the positive vision he modelled for us of ‘impure’ philosophy—a philosophical style he took to contribute to nurturing philosophy as a humanistic discipline.