bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Kompensasi Terhadap Kepuasan Kerja Karyawan Pada Departemen Store Bolly Sila
Authors: Andini Putri , Jaenab Jaenab 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui kompensasi berpengauh signifikan terhadap kepuasan kerja karyawan pada Departemen Store Bolly Sila. Jenis penelitian adalah penelitian asosiatif. Tehnik pengambilan sampel menggunakan purposive sampling yaitu sebanyak 45 orang responden. Istrumen penelitian yang di gunakan yaitu kuesioner dengan menggunakan skala likert. Tehnik analisis analisi data menggunakan regresi linear sederhana. Hasil penelitian ini menunjukan bahwa nilai sebesar t-hitung 5,133 sedangkan t-tabel 2,018 hasil ini menunjukkan bahwa nilai (t hitung > t tabel), maka H1 diterima dan Ho di tolak artinya kompensasi berpengaruh signifikan terhadap kepuasan kerja karyawan pada Departemen Store Bolly Sila.
Aproximaciones del libro blanco: implicaciones de la seguridad y defensa y la seguridad sanitaria
Authors: Sánchez Gómez, ERD Coronel MA (DEM) Rafael 
Published: May 2024

A propósito de los aprestos actuales para la consecución de la ela­boración del libro Blanco de República Dominicana, que consti­tuirá un hito sobre los aspectos normativos de políticas públicas y aspectos logísticos que conciernen a la Política de Seguridad y Defensa nacional, concibiéndose como una expresión clara de transparencia en su conformación, por lo que entre sus páginas se tratarán los aspectos más elementales para la defensa del interés nacional.
Antes las grandes dificultades (globales y nacionales), como con­secuencias de la epidemia del COVID-19, la seguridad sanitaria cobra la debida relevancia que corresponde a la crisis, siendo un tema de prioridad nacional que implica las recurrencia de medidas necesarias ante la emergencia propia de salud pública que se pre­senta, involucrando en su apoyo a las dependencias de seguridad y defensa del Estado como una experiencia global, (Ministerio de Defensa, 2020).
Al producirse un evento de salud pública de tal relevancia, la Organización Mundial de Salud (OMS), se ocupa de poner en vi­gencia las alertas y respuestas necesarias, mediante la coordina­ción de las operaciones de respuesta adecuadas, así como el suplir las informaciones más acertadas ante la crisis. La seguridad sanitaria mundial, a través de la aplicación en el 2005 del nuevo Reglamento de Salud Internacional (RSI), (Organización Mundial de la Salud, 2005), nos dice tener como propósito princi­pal «prevenir la propagación internacional de enfermedades, pro­teger contra esa propagación, controlarla y darle una respuesta de salud pública proporcionada».
A través de estas breves aproximaciones realizaremos un análisis ponderativo de nuestra política de seguridad y defensa a través de la concepción de un Libro Blanco, en momentos en que trascurre una crisis sanitaria. Por tanto, ante tales retos se hace necesario un amplio desglose normativos para lo que hacemos acotamientos de lugar, siendo factibles de ser aprovechados.
Assessment of Computer Literacy of the College Faculty of Nueva Ecija University of Science and Technology Gabaldon Campus
Authors: Arimbuyutan Ronaldo 
Published: May 2024

This study aimed to assess the computer literacy levels of the college faculty of Nueva Ecija University of Science and Technology – Gabaldon Campus. A total of 36 instructors from multiple non-computing departments participated in the study. The researcher assessed the levels in terms of computer skills, software use, and routine computer use. The study utilized the descriptive method of research using survey questionnaires that has six parts: general operations of computers, communication and internet, word processing, spreadsheet, graphics, and general technology application. After collecting the data needed, the data were tabulated, analyzed, and interpreted. The findings showed that the college faculty of the Nueva Ecija University of Science and Technology- Gabaldon Campus have limited skills in regards to general computer applications, communication, and the internet but are very proficient with word processing and spreadsheet. Moreover, the study found evidence that there should be a professional development training programs for instructors to incorporate computer technology as a classroom tool and means of managing instruction.
Suspects' Rights to Demand Compensation for Unlawful Detention at Cirebon Police Station
Authors: Febriyanto Zefri 
Published: May 2024

Law enforcement is one of the efforts to achieve or create order, security, and tranquility in society, both as an effort to prevent and eradicate or enforce a violation of the law. Criminal offense is a term derived from the Dutch translation of strafbaarfeit. The word strafbaarfeit was later translated into various languages in Indonesian. Some words used to translate strafbaarfeit by scholars in Indonesia include criminal acts, delicacies, and criminal acts. The type of research the author uses is descriptive writing, which provides data that is as thorough as possible about humans, conditions, or other symptoms. The point is to reinforce the hypothesis to help strengthen the old theory or within the framework of compiling new theories. The results of this study showed that in 2017, there was one pretrial application, and the judge's decision showed that it was not granted, while in 2018, there was no pretrial application. In 2019, there were also no pretrial applications, while in 2020, there were two pretrial applications, and the judge's decision showed that one pretrial application was granted and one was not. Implementing the fulfillment of the rights of suspects demanding compensation for unlawful detention in Cirebon Regency has not been optimal.
The Effect of SEFT and Acupressure St 18 on Breast Milk Production in Postpartum Mothers at Puskesmas Pangenan Cirebon Regency
Authors: HERMIYATI TRI , Tonasih Tonasih , Mutya Sari Vianty , Ratna Suminar Erni 
Published: May 2024

Puskesmas Pangenan masuk dalam 10 Puskesmas penyumbang terbanyak kasus stunting di Kabupaten Cirebon. Stunting dapat dicegah dengan pemberian ASI eksklusif. Faktor-faktor yang mempengaruhi Produksi ASI diantaranya adalah ketenangan jiwa dan pikiran dan perawatan payudara. Untuk mengatasi faktor tersebut maka dilakukan SEFT dan Akupresur ST 18. Tujuan Penelitian ini adalah untuk mengetahui pengaruh SEFT dan Akupresur ST 18 terhadap produksi ASI pada ibu nifas 6-72 jam. Metode Penelitian ini menggunakan metode quasi eksperiment dengan pretest-posttest with control group design. Populasi penelitian adalah ibu nifas 6-72 jam di UPTD Puskesmas Pangenan Kabupaten Cirebon tahun 2023 sebanyak 28 ibu nifas, dengan 14 ibu nifas 6-72 jam kelompok intervensi dan 14 ibu nifas 6-72 jam kelompok kontrol. Pengambilan sampel menggunakan teknik purposive sampling. Instrumen yang digunakan dalam penelitian ini adalah lembar observasi pengeluaran ASI, SOP Pemerahan ASI dan SOP SEFT dan Akupresur ST 18. Analisis data meliputi analisis univariat menggunakan distribusi frekuensi tendensi sentral dan analisis bivariat menggunakan uji paired t-tes dan uji t independen. Rata-rata jumlah produksi ASI setelah perlakuan SEFT dan Akupresur ST 18 adalah 25,86. Rata-rata jumlah produksi ASI pada ibu nifas setelah tanpa perlakuan SEFT dan Akupresur ST 18 adalah 23,93. SEFT dan Akupresure ST 18 berpengaruh terhadap peningkatan produksi ASI pada Ibu Nifas di UPTD Puskesmas Pangenan. Kesimpulan dari penelitian ini adalah Ada pengaruh SEFT dan Akupresur ST 18 terhadap produksi ASI pada ibu nifas, maka diharapkan petugas kesehatan dapat menerapkan SEFT dan Akupresur ST 18 untuk meningkatkan produksi ASI.
Correlation of SNR Value on DPOAE Examination with HSP70 Levels in Blood and HSP70 Expression in Cochlea of Noise Model Rattus norvegicus as an Indicator of Inner Ear Damage
Authors: Pratiwi Florensia Elita , Haryuna Tengku Siti Hajar , Adriztina Indri , Khalid Khalisanni 
Published: May 2024

Background: Cellular stress caused by noise-induced hearing loss can be observed through the damage of cochlear hair cells, mechanically and metabolically. SNR value on the DPOAE examination assesses the sensory function of cochlear outer hair cells. HSP70 as marker of cellular stress can be identified from its levels in blood and its expression in the cochlea.Methods: Three groups of rats were used for the noise intervention: Group 1 was the control group, Group 2 had a noise exposure of 100 dB, and Group 3 received a noise exposure of 110 dB. DPOAE examination was then conducted, blood samples from rats’ tail were collected after a noise treatment, followed by the measurement of HSP70 levels by ELISA readings. Rats were terminated afterwards and immunohistochemical examination of the cochlear organ of Corti was performed to calculate the expression of HSP70. The data obtained were analyzed using SPSS.Results: A decrease occurred in the values of SNR and an increase occurred in HSP70 levels in blood along with its expression in the cochlea of noise model Rattus norvegicus, and there is a correlation between the three.Conclusion: The decrease in SNR values, increase in HSP70 levels in blood, and increase in HSP70 expression in the cochlear organ of Corti of Rattus norvegicus, proves that noise-induced hearing loss triggers the production of HSP70 as a cytoprotective agent in preventing inner ear damage.Keywords: DPOAE; Rattus norvegicus; NIHL; Heat Shock Protein 70
Exploring Genomic Patterns to Identify Drug-Resistant TB: A Comprehensive Study of Age, Gender, Lineage, and Outcome
Authors: Tariq Anam , Fazal Sahar 
Published: May 2024

Background: Tuberculosis (TB) is a prevalent bacterial infection caused by Mycobacterium tuberculosis (Mtb), primarily affecting the lungs, with rising incidence rates. Drug-resistant TB strains, including multidrug-resistant (MDR) and extensively drug-resistant (XDR) types, pose challenges with poor treatment success rates and increased mortality. Demographic factors and genomic patterns contribute to drug resistance, emphasizing the need for new drugs targeting specific genomic patterns.Methods: This study analyzes the impact of demographics, treatment outcomes, and genomic mutations on drug-resistant TB using pattern identification techniques and whole-genome sequencing to discover therapeutic targets. This study primarily focused on the identification and analysis of MDR and XDR strains, considering various demographic characteristics and treatment outcomes. A dataset comprising 2,602 observations was utilized, and pattern recognition techniques were employed to identify significant features. Additionally, the study employs the whole-genome sequencing (WGS) pipeline to identify single nucleotide polymorphisms (SNPs) that result in new mutations in drug-resistant Mtb strains.Results: The findings of the study revealed that XDR and MDR non-XDR TB were the most prevalent types of drug resistance, and they were associated with unfavorable treatment outcomes, including death or treatment failure. Males exhibited a higher susceptibility to both XDR and MDR non-XDR TB compared to females. The age of onset for both types of resistance was approximately 40 years. Among the observed variants in 31 commonly occurring genes,Conclusion: These findings introduce a novel set of therapeutic targets specific to MDR and XDR Mtb types, which warrant further investigation for potential therapeutic interventions.Keywords: Tuberculosis; Drug Resistance; Multidrug resistance; Demographics; Dataset; Gene; Mutations
Antifungal Efficacy of the crude Alkaloid, Flavonoid, and Terpenoid of Saussurea costus (Falc.) Lipschitz Roots against Aspergillus species isolated from Rice Seeds
Authors: Al-Nafie Fatima S. , Hussein Hussein J. , Al-Rubaye Abeer F. 
Published: May 2024

Background: Rice is an essential component of the diets of people all over the world, and it accounts for a sizeable amount of the calories that they consume. The world's food supply suffers huge economic losses due to fungal deterioration on rice seeds. The medicinal plant Saussurea costus contains bioactive chemicals and is well-known for its many therapeutic uses. There are a number of species of Aspergillus that are considered to be diseases in vegetables and fruits. One of these species is Aspergillus niger. The purpose of this current investigation was to investigate the impact of the crude Alkaloid, Flavonoid, and Terpenoid chemicals derived from Saussurea costus' roots on Aspergillus species Purified from Rice seeds obtained from various markets in Hillah, Iraq.Methods: In vitro, antifungal activity against Aspergillus species was achieved using the food poisoning method. Three concentrations 5, 10, and 15mg/ml of each crude compound were prepared and compared to a positive control represented by Carbendazim500g/l and a negative control represented by 10% dimethyl sulfoxide.Results: An objective of the current investigation was to manage the Aspergillus species growth identified in Rice seeds by utilizing secondary compounds derived from the roots of Saussurea costus. The study's data indicated that the extracts represented by active compounds such as Alkaloids, Flavonoids, and Terpenoids obtained from Saussurea costus roots exhibited a significant decrease in the of Aspergillus species growth, particularly at a concentration of 100mg/ml, in contrast to the negative control. This effect was equivalent to that of the positive control, Carbendazim 500g/l.Conclusion: Finally, Saussurea costus roots have shown the most efficacy in controlling Aspergillus species, particularly through the presence of Alkaloid, Flavonoid, and Terpenoid chemicals at a concentration of 100mg/ml.Keywords: Antifungal activity; Saussurea costus; Alkaloids; Flavonoids; Terpenoids
Acquiring insights through a sequence-based approach to the critical Zika virus MTase domain
Authors: Atwah Banan , Alghamdi Saad , Saeedi Nizar H. , Alzahrani Abdulrahman , Alghamdi Rashed Mohammed , Akber Asif Hussain , Al Qahtani Mohammed Yahya , Mujarribi Atiah Abkar Yahya , Al Qahtani Saeed Saleh , Faqihi Ahmed Mohammed , Kamal Mohammad Azhar 
Published: May 2024

Background: ZIKV is one of the re-emerging arboviruses (viruses carried by arthropods), which is spread through the Aedes mosquito. It is an RNA virus with only one strand that is appropriate to the family Flaviviridae's Flavivirus (genus) & has been linked to other Flaviviruses such as the West Nile virus, chikungunya virus, & dengue (DENV) virus. The envelope, precursor membrane, and capsid are three structural proteins, and seven nonstructural proteins are also encoded by the Zika virus genome.Methods: We conducted an in-silico analysis of the Zika virus' MTase domain protein for this publication. We predicted that methylation would play a significant role in the available Prosite, Pfam, and InterProScan tools to aid in locating the MTase domain. Along with alignment, amino acid composition, charged amino acids, atomic level studies, & molecular weight, we also make predictions for these variables, including theoretical Pi.Results: We also examine the MTase domain's simulated structure (alpha helix, beta sheet, turn) and its specifics, including secondary structure. We also pinpoint the locations where proteins, DNA, and RNA bind. Potential phosphorylation sites can be found on the Ser, Thr, and Tyr residues in the MTase domain.Conclusion: These outcomes imply a complicated interaction between different phosphorylation modifications that modulates the activity of the MTase domain. To fully appreciate the auxiliary and practical perspectives and to clarify the varied roles of PTM in the MTase domain will be a primary goal of future study.Keywords: I-TASSER; Secondary structure; Prosite; α-helix; Pfam; InterProScan; Binding sites; Posttranslational modification; SOPMA; Phyre2
Structure-Based Virtual Screening of Antiviral Compounds Targeting the Norovirus RdRp Protein
Authors: Alqahtani Leena S , Alkathiri Ahmad Salah , Alzahrani Abdulrahman , Alghamdi Rashed Mohammed , Alamri Waad Abdulrahmman , Kamal Mohammad Azhar , Aloufi Ahmed Hamdan , Alamri Ali Saeed , Alam Qamre 
Published: May 2024

Background: Human noroviruses (NV) are the primary etiological organisms causing acute gastroenteritis around the world, causing severe morbidity and imposing a significant economic burden. The RNA-dependent RNA polymerase (RdRp) is essential for viral replication and could be a promising target for anti-NV therapeutics. Despite the discovery of a few NV RdRp inhibitors, the majority of these pharmaceuticals have demonstrated limited efficacy in inhibiting viral replication in cellular models.Methods: In this study, computational screening of antiviral compounds was conducted targeting the NV RdRp protein. The assessment was based on binding poses and the key residues of RdRp involved in interactions with compounds.Results: The compounds namely, Ribavirin, BMS806, Dihydromyricetin, R7935788, and LY2784544 were found to bind the RdRp protein with high affinity. Notably, these compounds displayed significantly lower binding affinities compared to the positive control, PPNDS. In addition, these compounds exhibited many RdRp protein binding residues that were also present in the PPNDS.Conclusion: The results presented here suggest that these compounds have the potential to be used as inhibitors of NV RdRp in the development of antiviral medications. Nevertheless, due to the computational nature of this study, it is imperative to do experimental validation.Keywords: Noroviruses; RdRp; Virtual screening; Antiviral Compounds
Iron-Based Nanoparticles Synthesis, Characterization, and Antimicrobial Effectiveness
Authors: Jaha Hisham Faiz , Anwar Yasir , Almaaqar Saleh , Khan Tahseen , Khan Sher Bahadar 
Published: May 2024

Background: Antimicrobial resistance (AMR) has emerged as a significant and pressing public health concern, posing serious challenges to effectively preventing and treating persistent diseases. Developing new antibiotics with different mechanisms of action is crucial to effectively address challenges in treating infections. A lot of work has already been done on mono-metallic nanoparticles to address the issue.Methods: This study aimed to synthesize multi-metallic iron, silver, and chitosan-embedded nanoparticles using a green approach. Iron, silver, chitosan nanoparticles, and a composite of iron–silver–chitosan was also synthesized. The synthesized nanoparticles and composites were characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and Fourier Transform Infrared Spectroscopy (FTIR) to evaluate their structural parameters. Their antimicrobial efficacy was investigated through MIC (minimum inhibitory concentration), MBC (minimum bactericidal concentration), and well-disk diffusion assays against Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Staphylococcus epidermidis and Candida albicans.Results: The size of the Cu-NPs, Cu-Ag NPs, and Cu-Ag-CS NPs were found to be in the range of 32-40 nm size with a spherical shape. The nanocomposites' MIC and MBC were calculated to be 125 μg/mL and 500 μg/mL, respectively. The nanocomposites exhibited a range of clear inhibition zones, with a minimum diameter of 12 ± 0.5 mm and a maximum diameter of 22 ± 0.5 mm. Conclusion: The iron–silver–chitosan nanocomposite has been shown to have significant antimicrobial effects in the laboratory environment compared to other nanoparticles hence can be applied as potential biomedical/biological candidates in future.Keywords: Antibacterial; Antifungal Agents; Iron; Silver; Chitosan; Nanoparticles
Potenciais implicações terapêuticas das nanopartículas de carboneto de nióbio na patogênese bacteriana e regeneração tecidual
Authors: Hakme da Silva Alessandro Márcio , Melo Wanessa , Ribeiro Ana Carolina de Campos , Simonato Luciana Estevam , Sanchez Guilherme Hernandes Garcia , Ferreira Paulo Henrique Dias 
Published: May 2024

Dentro da esfera da saúde humana, fenômenos como infecções bacterianas tenazes, persistência de biofilmes microbianos e a ascendente resistência antibiótica irreparável representam dilemas cruciais. Em um cenário onde o repertório estratégico para abordagens antimicrobianas e anti-biofilmes é incontestavelmente restrito, soluções nutridas por avanços interdisciplinares, especialmente nas áreas da bioengenharia e nanomedicina, têm emergido como estado da arte em pesquisas na formulação de intervenções antibacterianas pioneiras. Este manuscrito é pautado na análise dos mecanismos de interação das nanopartículas de Carbeto de Nióbio (NbC), realçando sua atuação como um potencial vetor tanto em esferas antimicrobianas quanto na recuperação tecidual. Estes paradigmas recém-revelados elucidam um potencial promissor na desestabilização de biofilmes, conduzindo à neutralização bacteriana por meio da regulação negativa das rotas metabólicas bacterianas, obstrução da inauguração de biofilme e intensificação do descolamento de biofilmes preexistentes, uma dinâmica intermediada por um sofisticado regulador genético adjunto. Uma faceta distintiva da proposta terapêutica reside na habilidade de primar bactérias por intermédio de transdução fototérmica, decrementando o patamar térmico essencial para a supressão bacteriana e atenuando consequentes insalubridades em tecidos íntegros circunjacentes. Em uma vertente complementar, a interação proposta evoca capacidade em orquestrar respostas pró-inflamatórias, sequestrando espécies reativas de oxigênio em excedência presentes em nichos infecciosos, impulsionando a angiogênese e a reconstrução tecidual otimizada.

Palavras-chave: nanopartículas; carboneto de nióbio; biofilme; agente antimicrobiano; reparo tecidual.
A disciplina “nutrição de cães e gatos” nos cursos de graduação em Zootecnia e Medicina Veterinária
Authors: Denise Rufino Bragança  
Published: May 2024

A nutrição desempenha um papel fundamental na saúde e bem-estar de cães e gatos, que passaram a ser membros de muitas famílias em todo o mundo. À medida que cresce a conscientização sobre a importância da nutrição animal, a demanda por profissionais de Medicina Veterinária e Zootecnia com conhecimento especializado nessa área está aumentando exponencialmente. Neste contexto, a docência no ensino superior desempenha um papel fundamental na formação dos futuros profissionais. Através de práticas educacionais eficazes, os educadores podem preparar os alunos não apenas com conhecimento técnico, mas também com as habilidades, valores e mentalidade necessários para enfrentar os desafios do mercado de trabalho em constante evolução. Este artigo de revisão de literatura tem como objetivo analisar a adequação do conteúdo programático e do plano de ensino adotados pelas universidades, nos cursos de graduação em Medicina Veterinária e Zootecnia no que diz respeito à disciplina de "Nutrição para Cães e Gatos". Além disso, são destacadas as habilidades que os alunos adquirem na disciplina, bem como explorar o quanto o mercado de trabalho demanda por profissionais que possuem expertise em nutrição de cães e gatos.
Pengaruh Harga, Promosi dan Green Product Terhadap Keputusan Pembelian Sayuran Hidroponik Darul Qur'an Bengkel
Authors: Sari Gesti Lovita , Supiandi Supiandi 
Published: May 2024

Penelitian ini bertujuan untuk menganalisis dan mengetahui pengaruh harga, promosi dan green product terhadap keputusan pembelian sayuran hidroponik Darul Qur’an Bengkel. Penelitian ini menggunakan jenis penelitian asosiatif kuantitatif. Metode pengumpulan data dilakukan melalui penyebaran kuesioner online. Sampel pada penelitian ini sebanyak 95 responden konsumen sayuran hidroponik Darul Qur’an Bengkel. Teknik pengambilan sampel menggunakan purposive sampling. Analisis data yang digunakan yaitu analisis regresi linier berganda. Hasil penelitian ini menunjukan bahwa harga berpengaruh tidak signifikan terhadap keputusan pembelian sayuran hidroponik Darul Qur’an Bengkel. Promosi dan green product berpengaruh signifikan terhadap keputusan pembelian sayuran hidroponik Darul Qur’an Bengkel