bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microvascular recovery with ultrasound in myocardial infarction post‐PCI trial
Authors: Li Shouqiang , Hovseth Chad , Xie Feng , Kadi Soufiane El , Kamp Otto , Goldsweig Andrew Michael , Mathias Wilson , Azevedo Luciene Ferreira , Porter Thomas Richard 
Published: June 2024

AbstractPurposePersistent microvascular obstruction (MVO) after successful percutaneous coronary intervention (PCI) in acute ST segment elevation myocardial infarction (STEMI) has been well‐described. MVO predicts lack of recovery of left ventricular function and increased mortality. Sonothrombolysis utilizing diagnostic ultrasound induced cavitation of commercially available microbubble contrast has been effective at reducing infarct size and improving left ventricular ejection fraction (LVEF) when performed both pre‐ and post‐PCI. However, the effectiveness of post‐PCI sonothrombolysis alone after successful PCI has not been demonstrated.MethodsA prospective randomized controlled trial was performed in 50 consecutive consenting patients with anterior STEMI who underwent a continuous microbubble infusion immediately following successful PCI. Intermittent high mechanical index (MI) impulses were applied only in the sonthrombolysis group. Delayed enhancement magnetic resonance imaging (MRI) was performed at 48 h and again at 6–8 weeks to assess for differences in infarct size, LVEF, and MVO.ResultsThere were no differences between groups in age, gender, and cardiovascular risk factors. Significant (> 2 segments) MVO following successful PCI was observed in 66% of patients. Although sonothrombolysis reduced the extent of MVO acutely, there were no differences in infarct size, LVEF, or extent of MVO by MRI at 48 h. Twenty‐eight patients returned for a follow up MRI at 6–8 weeks. LVEF improved only in the sonothrombolysis group (∆LVEF 7.81 ± 4.57% with sonothrombolysis vs. 1.77 ± 7.02% for low MI only, p = .011).ConclusionPost‐PCI sonothrombolysis had minimal effect on reducing myocardial infarct size but improved left ventricular systolic function in patients with acute anterior wall STEMI.
In‐Between Child and World: Educational Responsibility with and against Arendt
Authors: Kloeg Julien , Noordegraaf‐Eelens Liesbeth 
Published: June 2024

AbstractA key aspect of the educator's responsibility as understood by Hannah Arendt is its dual character. Educators are responsible for both the life and development of the child and the continuance of the world, as Arendt puts it in “The Crisis in Education.” Moreover, these aspects of responsibility are in tension with each other. Arendt's own accounts of responsibility in her political writings are, in a similar way, riddled with tension. What should we conclude from this about the nature of educational responsibility? To address this question, Julien Kloeg and Liesbeth Noordegraaf‐Eelens first reconstruct the meaning of responsibility in Arendt's political writings. They find a broad distinction between political responsibility and personal responsibility: the former consists in contributing to a community (by extension, the world), and the latter in the “two‐in‐one” of silent self‐dialogue. While political responsibility is close to Arendt's description of the responsibility of the educator (for the continuance of the world), personal responsibility does not find an obvious home in her educational thought. From this ambiguous situation of education and Arendt's own theme of the “in‐between” arises the possibility of introducing a concept of educational responsibility that further develops Arendt's position. Kloeg and Noordegraaf‐Eelens's concept of educational responsibility suggests a theory and practice of navigating tensions between conflicting commitments. In their view, this is both an appropriate extension and reform of Arendt's educational work and an insight that does justice to the practical situation of educators in the modern world.
In platform we trust(?) Concepts, problems and a case study about platform education
Authors: Cornali Federica 
Published: June 2024

AbstractDigitation in education, where online platforms play a central role, has changed teaching and learning scenarios. In addition, it has brought an unprecedented array of public and private actors into the educational arena who provide schools with technological solutions for redesigning learning environments and practices. Though the arena is dominated by EdTech companies, non‐profit initiatives are not entirely absent. After a brief introduction to the main issues relating to the spread of educational platforms, this article will present a rare case of a non‐commercial educational platform developed, implemented and managed in complete autonomy by a community of university students.
Family‐centered profiles of mindful parenting: Longitudinal associations with negative parenting and youth emotional and behavioral problems
Authors: Larrucea‐Iruretagoyena Maite , Parent Justin , Orue Izaskun 
Published: June 2024

AbstractThere has been great interest in analyzing the potential of mindful parenting in promoting family well‐being. Studies indicated that there is a lack of research on the predictive relationship between parenting practice and youth emotional and behavioral problems analyzed from a multi‐informant perspective. This study evaluates the family‐centered profiles of mothers and fathers' mindful parenting and negative parenting and youth problems associated with those profiles. A total of 441 youths (aged 9–14 years), along with their parents, answered self‐report questionnaires in a three‐wave longitudinal study conducted over 1 year. A latent profile analysis was performed to examine the mindful parenting profiles and to identify their associations with youth emotional and behavioral problems and negative parenting as outcomes. The results of latent profile analyses supported a three‐profile solution: low mindful parenting family (35%), high maternal mindful parenting family (24%), and average mindful parenting family (41%). The low mindful parenting family profile showed the highest scores on negative parenting and youth emotional and behavioral problems. The high maternal mindful parenting family profile had the lowest scores on youth negative outcomes but demonstrated similar levels to those of the average mindful parenting family profile regarding negative parenting. Our findings highlight the importance of analyzing specific family profiles that help to develop personalized interventions with optimized treatments regarding family cohesion and environment.
The impact of divorce education programs on co‐parental conflict: Review of programs with parent follow‐up reports
Authors: Guyette Erin , Harris Steven M. 
Published: June 2024

AbstractDivorce education programs are often required for divorcing or separating parents with minor children to aid in emotional and practical adjustment. However, there is very little consensus between programs or the evaluation process of programs to demonstrate effectiveness or long‐term outcomes. While some short‐term evaluations have shown significant results, the identification of programs that demonstrate long‐term effects on co‐parenting relationships is still missing. Identifying what programs exist with long‐term outcomes can help pinpoint what content or structure of programming is impactful on families in divorce transitions. To address this research gap, a systematic review of the literature was conducted using the PRISMA guidelines to identify what specific and existing divorce education programs have a follow‐up report of a minimum of 3 months and demonstrate a reduction of co‐parental conflict. Sixteen programs were identified that have at least a minimum 3‐month parent follow‐up report; only four of these programs demonstrated statistically significant reductions in co‐parental conflict. A discussion and critique of the program evaluation articles are within this review.
The effect of fiber bridging on mode I fatigue delamination propagation—part I: Testing
Authors: Banks‐Sills Leslie , Gur Hila Ben 
Published: June 2024

AbstractThe purpose of this investigation is to assess the effect of fiber bridging on fatigue delamination propagation. Fiber bridging occurs when testing beam type laminates specimens consisting of unidirectional plies. Unidirectional double cantilever beam specimens composed of the carbon fiber reinforced polymer prepreg AS4/8552 were tested by means of fatigue cycling. A Paris relation was determined based on these tests. Fiber bridging in beam specimens composed of unidirectional plies causes the apparent fatigue delamination curves to exhibit slower growth predicting overly conservative results. In Part I of this study, the effect of fiber bridging was eliminated experimentally from the results. In Part II of this study, a cohesive zone model is developed and used to carry out finite element analyses to simulate the experiments, as well as to eliminate the influence of fiber bridging.
Sentencing individuals on cusp‐cases: The use of offenders’ backgrounds by Scottish Sheriffs
Authors: Velásquez‐Valenzuela Javier 
Published: June 2024

AbstractTo what extent are accused's backgrounds within the criminal justice system considered during the sentencing process, and if they are, how do judges make sense of them? To better understand this aspect of the sentencing process, this article examines data from interviews with, and observations of, 16 Sheriffs in 14 different Scottish Sheriff Courts. The accused persons’ backgrounds were indeed considered during the sentencing process. However, how Sheriffs constructed their role as sentencers seemed to directly affect how they acknowledged and took them into account.
Targeted metabolomics analysis approach to unravel the biofilm formation pathways of Enterococcus faecalis clinical isolates
Authors: Suriyanarayanan Tanujaa , Lee Lye Siang , Han Sharon Hong Yu , Ching Jianhong , Seneviratne Chaminda J. 
Published: June 2024

AbstractAim(i) To characterize Enterococcus faecalis biofilm formation pathways by semi‐targeted metabolomics and targeted nitrogen panel analysis of strong (Ef63) and weak (Ef 64) biofilm forming E. faecalis clinical isolates and (ii) to validate the identified metabolic markers using targeted inhibitors.MethodologyPrevious proteomics profiling of E. faecalis clinical isolates with strong and weak biofilm formation revealed that differences in metabolic activity levels of small molecule, nucleotide and nitrogen compound metabolic processes and biosynthetic pathways, cofactor metabolic process, cellular amino acid and derivative metabolic process and lyase activity were associated with differences in biofilm formation. Hence, semi‐targeted analysis of Ef 63, Ef 64 and ATC control strain Ef 29212 was performed by selecting metabolites that were part of both the previously identified pathways and a curated library with confirmed physical and chemical identity, followed by confirmatory targeted nitrogen panel analysis. Significantly regulated metabolites (p < .05) were selected based on fold change cut‐offs of 1.2 and 0.8 for upregulation and downregulation, respectively, and subjected to pathway enrichment analysis. The identified metabolites and pathways were validated by minimum biofilm inhibitory concentration (MBIC) and colony forming unit (CFU) assays with targeted inhibitors.ResultsMetabolomics analysis showed upregulation of betaine, hypoxanthine, glycerophosphorylcholine, tyrosine, inosine, allantoin and citrulline in Ef 63 w.r.t Ef 64 and Ef 29212, and thesemetabolites mapped to purinemetabolism, urea cycle and aspartate metabolism pathways. MBIC and CFU assays using compounds against selected metabolites and metabolic pathways, namely glutathione against hypoxanthine and hydroxylamine against aspartate metabolism showed inhibitory effects against E. faecalis biofilm formation.ConclusionsThe study demonstrated the importance of oxidative stress inducers such as hypoxanthine and aspartate metabolism pathway in E. faecalis biofilm formation. Targeted therapeutics against these metabolic markers can reduce the healthcare burden associated with E. faecalis infections.
Stockpiling‐based pricing and its welfare effects
Authors: Li Ruochen 
Published: June 2024

AbstractConsumer stockpiling involves the intertemporal demand substitution that allows the firm to differentiate stockpilers from others and employ varying pricing strategies. In this paper, I set up a two‐period monopoly model that incorporates consumer stockpiling behavior to investigate the effect of stockpiling‐based pricing. In equilibrium, I show that when the level of heterogeneity among consumers is high, consumer stockpiling can be used as a device for the firm to identify preferences and price discrimination. Welfare analysis suggests that consumer stockpiling improves consumer surplus and profit despite the associated stockpiling‐based pricing.
Uncovering Complexities in Reducing Aggression, Conflict and Restrictive Practices in Acute Mental Healthcare Settings: An Overview of Reviews
Authors: Daguman Esario IV , Hutchinson Marie , Lakeman Richard 
Published: June 2024

ABSTRACTAggression, conflict and restrictive practices present complexities in acute mental health services, as do implementing service changes to reduce them. Existing published literature needs to offer more high‐level guidance on the effectiveness of these service changes and their associated implementation factors. As a result, an overview of systematic reviews was undertaken to identify (i) nonpharmacological interventions to reduce conflict, aggression and restrictive practices in acute mental health settings, and (ii) their effects across different clinical outcomes. A parallel re‐extraction from primary studies was then utilised (iii) to identify factors influencing successful intervention implementation. Of 124 articles sourced from nine databases and registries, four reviews were retained for the final analysis, using the direction of effect and tabular and narrative summaries. These reviews included programmes or interventions focused on inpatient adolescent, adult and older adult populations. They reported on alternative containment strategies, risk assessments, Safewards, sensory rooms and equipment, Six Core Strategy–based interventions and staff training. The overview found that a combination of interventions intended to improve relationships and reduce interpersonal conflict may help reduce aggression, conflict and restrictive practices. At the same time, stand‐alone staff training and sensory rooms and equipment may have mixed effects. The quality of the evidence linking these interventions to reductions in aggression, conflict and restrictive practices is limited. Successful implementation hinges on multiple factors: intervention characteristics, preparation and planning, evaluation and monitoring, outcome interpretation, stakeholder involvement/investment, staff‐related factors and contextual factors. Any implementation initiative may benefit from using pragmatic and complexity‐informed research methodologies, including integrating meaningful involvement with service users, peer workers and culturally diverse groups.
‘I've got to go in there with my armour on’: Adverse Childhood Experiences Among Adults Who Frequently Attend Emergency Departments
Authors: Binnie Vicki , Jessup Melanie , Le Brocque Robyne , Johnston Amy N. B. 
Published: June 2024

ABSTRACTFrequent presentations to emergency departments contribute to increased service demands and healthcare costs. Literature suggests these adult presentations may be influenced by childhood adversity. This qualitatively driven, mixed methods study explored the self‐perceived role of childhood adversity in the health of adults who frequently attended Australian Emergency Departments and their perceptions of the healthcare they received. Data were collected using validated instruments and semi‐structured interviews with 12 purposefully sampled adults who frequently attended emergency departments. Qualitative data were analysed using interpretive phenomenological analysis. Three major themes were identified—The experience of childhood adversity: articulating challenges related to childhood trauma, and the subsequent impacts on participants' health, behaviours, relationships and sense of control; Pursuing safety: exploring action participants took to keep themselves and others safe, with this requirement extending into adulthood and influencing Emergency Department presentations; and Seeking humanising healthcare: identifying challenges participants experienced while seeking care in the Emergency Department. Participants perceived their mental health to be profoundly affected by their past experiences of trauma, leaving them feeling vulnerable at times and more likely to experience re‐traumatisation in the Emergency Department. Feelings of stigmatisation during Emergency Department encounters led participants to employ self‐protection strategies creating further barriers to recovery. Participants described Emergency Departments as often failing to comprehensively address their healthcare needs. They offered suggestions for more effective care interventions. Findings highlight the need for further research to inform policy and practice when designing and implementing interventions for these adults. Consolidated Criteria for Reporting Qualitative Research (COREQ) guided study reporting.
A win‐win platform: Stabilized black phosphorous nanosheets loading gallium ions for enhancing the healing of bacterial‐infected wounds through synergistic antibacterial approaches
Authors: Li Zhiwei , Ren Jiwei , Sui Xin , Yang Nan , Li Sijia , Qi Le , Li Sining , Fan Yixin , Liu Zhihui 
Published: June 2024

AbstractBacterial infection is the most common complication in wound healing, highlighting an urgent need for the development of innovative antibacterial technologies and treatments to address the growing threats posed by bacterial infections. Black phosphorus nanosheets (BPNSs), as a promising two‐dimensional nanomaterial, have been utilized in treating infected wounds. However, BP's limited stability restricts its application. In this study, we enhance BP's stability and its antibacterial properties by anchoring gallium ions (Ga3+) onto BP's surface, creating a novel antibacterial platform. This modification reduces BP's electron density and enhances its antibacterial capabilities through a synergistic effect. Under near‐infrared (NIR) irradiation, the BP/Ga3+ combination exerts antibacterial effects via photothermal therapy (PTT) and photodynamic therapy (PDT), while also releasing Ga3+. The Ga3+ employ a ‘Trojan horse strategy’ to disrupt iron metabolism, significantly boosting the antibacterial efficacy of the complex. This innovative material offers a viable alternative to antibiotics and holds significant promise for treating infected wounds and aiding skin reconstruction.
Dielectric properties of disordered A6B2O17 (A = Zr; B = Nb, Ta) phases
Authors: Spurling R. Jackson , Almishal Saeed S. I. , Casamento Joseph , Hayden John , Spangler Ryan , Marakovits Michael , Hossain Arafat , Lanagan Michael , Maria Jon‐Paul 
Published: June 2024

AbstractWe report on the structure and dielectric properties of ternary A6B2O17 (A = Zr; B = Nb, Ta) thin films and ceramics. Thin films are produced via sputter deposition from dense, phase‐homogenous bulk ceramic targets, which are synthesized through a reactive sintering process at 1500°C. Crystal structure, microstructure, chemistry, and dielectric properties are characterized by X‐ray diffraction and reflectivity, atomic force microscopy, X‐ray photoelectron spectroscopy, and capacitance analysis, respectively. We observe relative permittivities approaching 60 and loss tangents <1 × 10−2 across the 103–105 Hz frequency range in the Zr6Nb2O17 and Zr6Ta2O17 phases. These observations create an opportunity space for this novel class of disordered oxide electroceramics.
Step‐by‐step recommendations utilizing four‐dimensional intracardiac echocardiography in left atrial appendage procedures
Authors: Gidney Brett , Della Rocca Domenico G. , Horton Rodney , Hoffman Joel , Valderrábano Miguel , Natale Andrea , Garg Jalaj , Bhardwaj Rahul , Doshi Shephal 
Published: June 2024

AbstractIntroductionFour‐dimensional (4D) intracardiac echocardiography (ICE) is a novel cardiac imaging modality that has been applied to various workflows, including catheter ablation, tricuspid valve repair, and left atrial appendage occlusion (LAAO). The use of this type of advanced ICE imaging may ultimately allow for the replacement of transesophageal echocardiography (TEE) for LAAO, providing comparable imaging quality while eliminating the need for general anesthesia.MethodsBased on our initial clinical experience with 4D ICE in LAAO, we have developed an optimized workflow for the use of the NUVISION™ 4D ICE Catheter in conjunction with the GE E95 and S70N Ultrasound Systems in LAAO. In this manuscript, we provide a step‐by‐step guide to using 4D ICE in conjunction with compatible imaging consoles. We have also evaluated the performance of 4D ICE with the NUVISION Ultrasound Catheter versus TEE in one LAAO case and present those results here.ResultsIn our comparison of 4D ICE using our optimized workflow with TEE in an LAAO case, ICE LAA measurements were similar to those from TEE. The best image resolution was seen via ICE in 2‐dimensional and multislice modes (triplane and biplane). The FlexiSlice multiplanar reconstruction tool, which creates an en‐face image derived from a 4D volume set, also provided valuable information but yielded slightly lower image quality, as expected for these volume‐derived images. For this case, comparable images were obtained with TEE and ICE but with less need to reposition the ICE catheter.ConclusionThe use of optimized 4D ICE catheter workflow recommendations allows for efficient LAAO procedures, with higher resolution imaging, comparable to TEE.
Single‐cell combined with transcriptome sequencing to explore the molecular mechanism of cell communication in idiopathic pulmonary fibrosis
Authors: Zhu Minggao , Yi Yuhu , Jiang Kui , Liang Yongzhi , Li Lijun , Zhang Feng , Zheng Xinglong , Yin Haiyan 
Published: June 2024

AbstractIdiopathic pulmonary fibrosis (IPF) is a common, chronic, and progressive lung disease that severely impacts human health and survival. However, the intricate molecular underpinnings of IPF remains elusive. This study aims to delve into the nuanced molecular interplay of cellular interactions in IPF, thereby laying the groundwork for innovative therapeutic approaches in the clinical field of IPF. Sophisticated bioinformatics methods were employed to identify crucial biomarkers essential for the progression of IPF. The GSE122960 single‐cell dataset was obtained from the Gene Expression Omnibus (GEO) compendium, and intercellular communication potentialities were scrutinized via CellChat. The random survival forest paradigm was established using the GSE70866 dataset. Quintessential genes were selected through Kaplan–Meier (KM) curves, while immune infiltration examinations, functional enrichment critiques and nomogram paradigms were inaugurated. Analysis of intercellular communication revealed an intimate potential connections between macrophages and various cell types, pinpointing five cardinal genes influencing the trajectory and prognosis of IPF. The nomogram paradigm, sculpted from these seminal genes, exhibits superior predictive prowess. Our research meticulously identified five critical genes, confirming their intimate association with the prognosis, immune infiltration and transcriptional governance of IPF. Interestingly, we discerned these genes' engagement with the EPITHELIAL_MESENCHYMAL_TRANSITION signalling pathway, which may enhance our understanding of the molecular complexity of IPF.