bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary care cardiology for patients with hypoplastic left heart syndrome
Authors: Boris Jeffrey R. 
Published: December 2011

AbstractPrimary care cardiology is also known as ambulatory cardiology and outpatient cardiology. Primary care cardiology for the longitudinal management of patients with hypoplastic left heart syndrome is both poorly described and has limited evidence to justify its basis. This article briefly discusses the various complications that these patients can develop, reviews the medical literature, and describes a framework for the care of these complex patients from infancy to transition to care by specialists in adults with congenital cardiac disease.
Feeding, growth, nutrition, and optimal interstage surveillance for infants with hypoplastic left heart syndrome
Authors: Hehir David A. , Cooper David S. , Walters Elizabeth M. , Ghanayem Nancy S. 
Published: December 2011

AbstractImprovement in operative survival of patients with hypoplastic left heart syndrome has led to increasing emphasis on prevention of interstage mortality. Many centres have improved interstage results through programmes of home monitoring following discharge after the Norwood (Stage 1) operation. Experience with heightened interstage surveillance has identified failure to thrive during infancy as a modifiable risk factor for this population, one that has been linked to concerning outcomes at subsequent palliative surgeries. Ensuring normal growth as an infant has thus become a priority of management of patients with functionally univentricular hearts. Herein, we review the existing evidence for best practices in interstage surveillance and optimal nutrition in infants with functionally univentricular hearts. In addition, we highlight data presented at HeartWeek 2011, from Cardiology 2011, the 15th Annual Update on Pediatric and Congenital Cardiovascular Disease, and the 11th Annual International Symposium on Congenital Heart Disease.
Extracorporeal cardiopulmonary resuscitation for post-operative cardiac arrest: indications, techniques, controversies, and early results – what is known (and unknown)
Authors: Chai Paul J. , Jacobs Jeffrey P. , Dalton Heidi J. , Costello John M. , Cooper David S. , Kirsch Roxanne , Rosenthal Tami , Graziano Joseph N. , Quintessenza James A. 
Published: December 2011

AbstractExtracorporeal cardiopulmonary resuscitation may be defined as the use of extracorporeal membrane oxygenation for the support of patients who do not respond to conventional cardiopulmonary resuscitation. Data from national and international paediatric databases indicate that the use of extracorporeal cardiopulmonary resuscitation is increasing. Guidelines from the American Heart Association suggest that any patient with refractory cardiopulmonary resuscitation and potentially reversible causes of cardiac arrest is a candidate for extracorporeal cardiopulmonary resuscitation. One possible framework for selection of patients for extracorporeal cardiopulmonary resuscitation includes dividing patients on the basis of favourable or unfavourable characteristics. Favourable characteristics include cardiac disease, witnessed event in the intensive care unit, ability to deliver effective cardiopulmonary resuscitation, active patient monitoring present, favourable arterial blood gases, and early institution of extracorporeal membrane oxygenation. Unfavourable characteristics potentially include non-cardiac disease, an unwitnessed cardiac arrest, ineffective cardiopulmonary resuscitation, and severely acidotic arterial blood gases. Considering the significant resources and cost involved in the use of extracorporeal cardiopulmonary resuscitation, its use needs to be critically examined to improve outcomes, assess neurological recovery and quality of life, and help identify populations and other factors that may help guide in the selection of patients for successful extracorporeal cardiopulmonary resuscitation.
Foetal cardiac intervention: an ethical perspective
Authors: Mavroudis Constantine D. 
Published: December 2011

AbstractAlthough recent advances have helped identify cases where foetal cardiac surgery might reverse the development of certain lesions, the indications and measurement of success in these procedures have yet to be established. Thus, both patients and physicians have a “burden of knowledge”, whereby a diagnosis is made without a clear course of action. The profound issues raised by foetal intervention, specifically the question of how concepts such as “patient” and “success” can be used, complicate this burden further and test the limits of language and logic. Similar issues raised in postmodern philosophy are discussed and can be incorporated into foetal cardiac surgery dialogues to produce a multi-disciplinary approach that will elucidate, not obfuscate, these issues in the future.
Changing attitudes to the management of hypoplastic left heart syndrome: a European perspective
Authors: Murtuza Bari , Elliott Martin J. 
Published: December 2011

AbstractBackground and aimsSeveral years ago, one of us described the difference in attitude to patients with hypoplastic left heart syndrome in the United States of America and Europe as similar to that between Mars and Venus. Uncertainty remains with regard to the long-term prognosis for patients with hypoplastic left heart syndrome. This prognosis may be considered in terms of survival, functional performance, including exercise capacity and neurodevelopment, as well as psychosocial effects on the patient, family, and siblings. Counselling parents where either an antenatal or postnatal diagnosis of hypoplastic left heart syndrome has been made requires practitioners to give information on these prognostic aspects. We wanted to see how attitudes among European surgeons have changed over the last few years.MethodsWe performed a review of recent European data for hypoplastic left heart syndrome and conducted a survey among surgeons in major European centres to ascertain key aspects of their attitudes to the management of patients with hypoplastic left heart syndrome and how they counsel parents.Results and conclusionsAs of January, 2011, 2392 citations in the PubMed database were available for the search string “hypoplastic left heart”. The majority of these were from the centres from the United States of America and Europe. The European Association for Cardio-Thoracic Surgery Congenital Heart Surgery Database shows an annual increase in the number of Norwood (Stage I) operations for hypoplastic left heart syndrome from 2003 to 2009, with a corresponding reduction in mortality. European rates of antenatal detection vary widely between centres, as do the rates of termination for a prenatal diagnosis of hypoplastic left heart syndrome. We observed a wide variation in the estimates of surgeons for survival and quality of life for surgical palliation of hypoplastic left heart syndrome, as well as in their estimates for actual rates of termination of pregnancy in their centres. Further, there was marked inconsistency in the information given to parents as part of the process of counselling. These issues remain to be resolved if parents are to make a fully informed decision for their child.
Deutsche Suchthilfestatistik 2009
Authors: Pfeiffer-Gerschel Tim , Künzel Jutta , Steppan Martin 
Published: December 2011

Fragestellung: Darstellung von Behandlungs- und Patientenmerkmalen ambulanter und stationärer Einrichtungen der Suchtkrankenhilfe in Deutschland für das Jahr 2009. Methodik: Die Auswertung basiert auf aggregierten Daten von N = 936 (779 ambulanten und 157 stationären) Einrichtungen, die sich im Berichtsjahr 2009 an der DSHS beteiligt und 316.075 Betreuungen in ambulanten und 38.618 Behandlungen in stationären Einrichtungen dokumentiert haben. Voraussetzung für die Teilnahme der Einrichtungen an der DSHS ist eine Dokumentation der Arbeit entsprechend der Vorgaben des KDS (Deutscher Kerndatensatz). Auf der Grundlage des am IFT geführten Registers der Facheinrichtungen der Suchtkrankenhilfe in Deutschland kann für den ambulanten Bereich eine Erreichungsquote von 69 bis 74 % angenommen werden, für den stationären Bereich von 43 bis 48 %. Ergebnisse: Wie bereits in den Vorjahren stellen sowohl im ambulanten als auch im stationären Bereich Patienten mit Störungen aufgrund des Konsums von Alkohol (ambulant 56 %, stationär 75 % der Betreuungen), Opioiden (ambulant 18 %, stationär 9 % ) und Cannabis (ambulant 14 %, stationär 5 %) die drei größten Hauptdiagnosegruppen. Männer weisen dabei hinsichtlich der Zahl der Betreuungen und Behandlungen wesentlich höhere Anteile bei (fast) allen Hauptdiagnosen auf. Die durchschnittlichen Behandlungsdauern sind für alle Hauptdiagnosegruppen im ambulanten Bereich länger (m = 168 [Pathologisches Glücksspiel, PG] – 336 [Alkohol, Opioide] Tage mittlere Behandlungsdauer) als im stationären Bereich (m = 78 [PG] – 112 [Stimulantien] Tage). Der Anteil planmäßiger Beender ist vor allem bei Patienten mit primär Alkohol-bezogenen Störungen oder pathologischem Glücksspiel in stationären Einrichtungen deutlich höher als in der ambulanten Versorgung. Bei Opioid-, Cannabis- und Stimulantienkonsumenten gibt es keine vergleichbar gravierenden Unterschiede. Sowohl in den ambulanten als auch in den stationären Einrichtungen kamen über 80 % (ambulant) bzw. 92 % (stationär) der Personen mit einem planmäßigen Betreuungs-/Behandlungsende auch zu einem positiven Gesamtergebnis der durchgeführten Intervention.
Role of structurally and magnetically modified nanoclusters in colossal magnetoresistance
Authors: Tao Jing , Niebieskikwiat Dario , Jie Qing , Schofield Marvin A. , Wu Lijun , Li Qiang , Zhu Yimei 
Published: December 2011

It is generally accepted that electronic and magnetic phase separation is the origin of many of exotic properties of strongly correlated electron materials, such as colossal magnetoresistance (CMR), an unusually large variation in the electrical resistivity under applied magnetic field. In the simplest picture, the two competing phases are those associated with the material state on either side of the phase transition. Those phases would be paramagnetic insulator and ferromagnetic metal for the CMR effect in doped manganites. It has been speculated that a critical component of the CMR phenomenon is nanoclusters with quite different properties than either of the terminal phases during the transition. However, the role of these nanoclusters in the CMR effect remains elusive because the physical properties of the nanoclusters are hard to measure when embedded in bulk materials. Here we show the unexpected behavior of the nanoclusters in the CMR compound La

1-
x

Ca

x

MnO
3
(0.4 ≤
x
< 0.5) by directly correlating transmission electron microscopy observations with bulk measurements. The structurally modified nanoclusters at the CMR temperature were found to be ferromagnetic and exhibit much higher electrical conductivity than previously proposed. Only at temperatures much below the CMR transition, the nanoclusters are antiferromagnetic and insulating. These findings substantially alter the current understanding of these nanoclusters on the material’s functionality and would shed light on the microscopic study on the competing spin-lattice-charge orders in strongly correlated systems.
Paradox and potential: trends in science policy and practice in Canada and New Zealand
Authors: Halliwell Janet , Smith Willie 
Published: December 2011

Over the last 30 years, Canada and New Zealand have redirected their science and research systems to meet changing national priorities, and in response to global trends and needs. They have shared a common effort to transform their traditionally resource-based economies. Both are committed to the creation of knowledge-based economies that can compete internationally in the face of massive globalization and the rise of the BRIC nations (Brazil, Russia, India and China). Research, and science and technology, are seen as the primary drivers towards this goal.
Canada and New Zealand developed science systems shaped by their common British heritage. In recent years, their science systems have undergone fundamental changes, yet they continue to share many evolving trends, highlighted in the ideas, methods, values and norms identified as Mode 2, in The New Production of Knowledge. These trends, however, have been shaped by different policies and different institutional arrangements, different theoretical perspectives and different political ideologies.
Reversing the Tapestry:Prison of Lovein Text, Image, and Textile*
Authors: Francomano Emily C. 
Published: December 2011

AbstractIn the 1520s the internationally popular romancePrison of Lovewas adapted as a series of tapestries known asL'Histoire de Lérian et Lauréolle. This article explores the translation of the romance to a larger-than-life, three-dimensional narrative object created from sumptuous materials that literally enveloped courtly life. Unlike previous studies ofPrison of Love's international reach, this article reads the tapestry chamber as an integral part of the romance's complex history of transmission among the princely courts of Europe in the early sixteenth century. Further, study of the textiles’ production, use, and reception will show that the tapestry chamber, though incomplete, is material evidence of a particular sixteenth-century reading of the romance.
Hymnic Epic andThe Faerie Queene’s Original Printed Format: Canto-Canticles and Psalmic Arguments*
Authors: Borris Kenneth , Donaldson Clark Meredith 
Published: December 2011

AbstractWhen Edmund Spenser (1552?–99) published hisFaerie Queenein 1590 and 1596, two pervasive structural features would have seemed surprising: the abbreviationCant.in sectional and running titles, used instead ofCanto;and a four-line stanza of common meter for each section's argument, instead of a more expansive and prestigious stanza. Study of the relevant early modern Italian and English norms of publication indicates that these were complementary and innovative means of merging heroic form with divine poetry and hymnic discourse, and recognized as such.Cant.readily suggestedcanticleand the Solomonic Canticles, and the poet himself calls one of his so-called cantos a “canticle” (4.5.46). In style and prosodic form, his arguments would have particularly evoked the nationally distinctive Elizabethan Protestant psalmody and hymnody, as well as popular ballads. By incorporating these two metamorphic devices intoThe Faerie Queene's framework, Spenser reconfigured the heroic poem to serve his different, English vision.
Children's Behavior in the Postanesthesia Care Unit: The Development of the Child Behavior Coding System-PACU (CBCS-P)
Authors: Chorney Jill MacLaren , Tan Edwin T. , Martin Sarah R. , Fortier Michelle A. , Kain Zeev N. 
Published: December 2011

Abstract
Objective To develop and validate a behavioral coding measure, the Children's Behavior Coding System-PACU (CBCS-P), for children's distress and nondistress behaviors while in the postanesthesia recovery unit. Methods A multidisciplinary team examined videotapes of children in the PACU and developed a coding scheme that subsequently underwent a refinement process (CBCS-P). To examine the reliability and validity of the coding system, 121 children and their parents were videotaped during their stay in the PACU. Participants were healthy children undergoing elective, outpatient surgery and general anesthesia. The CBCS-P was utilized and objective data from medical charts (analgesic consumption and pain scores) were extracted to establish validity. Results Kappa values indicated good-to-excellent (κ's &gt; .65) interrater reliability of the individual codes. The CBCS-P had good criterion validity when compared to children's analgesic consumption and pain scores. Conclusions The CBCS-P is a reliable, observational coding method that captures children's distress and nondistress postoperative behaviors. These findings highlight the importance of considering context in both the development and application of observational coding schemes.
First Report of Bacterial Leaf Spot of Basil Caused by Pseudomonas viridiflava in Hungary
Authors: Végh A. , Hevesi M. , Némethy Zs. , Palkovics L. 
Published: December 2011

In April 2011, typical bacterial spot symptoms were observed on sweet basil plantlets (Ocimum basilicum L.) in a supermarket in Budapest, Hungary. Affected plants had dark brown-to-black lesions on the cotyledons. Spots on the leaves were first water soaked and then became necrotic and progressed inward from the margins. Symptoms were similar to those reported by Little et al. (3) on basil affected by Pseudomonas viridiflava. Bacteria consistently isolated from leaf lesions formed mucoid colonies with a green fluorescent pigment on King's B medium. Strains were gram negative. In LOPAT (levan-oxidase-potato rot-arginine dihydrolase-tobacco hypersensitivity) tests (2), all induced a hypersensitive reaction (HR) in tobacco (Nicotiana tabacum L. cv. White Burley) leaves (1), caused soft rot of potato tuber slices, and were negative for levan, oxidase, and arginine dihydrolase. Biochemical tests, API 20NE and API 50 CH (Biomérieux, Marcy l'Etoile, France), were also used for identification. The pathogenicity of three isolates was tested twice by injecting 20-day-old healthy basil plants with a bacterial suspension (107 CFU/ml). Controls were injected with sterile distilled water. Plants were kept at 25 to 28°C and 80 to 100% relative humidity. Forty-eight hours after inoculation, dark brown-to-black lesions were observed only on inoculated plants. The bacterium was reisolated from lesions of all plants tested, fulfilling Koch's postulates. No lesions were observed on controls. To identify the pathogen, a PCR technique was used. The 16SrDNA region was amplified with general bacterial primer pair (63f forward and 1389r reverse) (4) then the PCR products were cloned into Escherichia coli DH5α cells and a recombinant plasmid was sequenced by M13 forward and reverse primers. The sequence was deposited in GenBank (Accession No. HE585219). On the basis of the symptoms, biochemical tests, and 16SrDNA sequence homology (99% sequence similarity with a number of P. viridiflava isolates), the pathogen was identified as P. viridiflava. To our knowledge, this is the first report of bacterial leaf spot of basil in Hungary, which can seriously affect the basil production. References: (1) Z. Klement. Nature 199:299, 1963. (2) R. A. Lelliot et al. Appl. Bacteriol. 29:470, 1966. (3) E. L. Little et al. Plant Dis. 78:831, 1994. (4) A. M. Osborn et al. Environ. Microbiol. 2:39, 2000.
A Deletion in NRT2.1 Attenuates Pseudomonas syringae-Induced Hormonal Perturbation, Resulting in Primed Plant Defenses
Authors: Camañes Gemma , Pastor Victoria , Cerezo Miguel , García-Andrade Javier , Vicedo Begonya , García-Agustín Pilar , Flors Victor 
Published: December 2011

Abstract
For an efficient defense response against pathogens, plants must coordinate rapid genetic reprogramming to produce an incompatible interaction. Nitrate Trasnporter2 (NRT2) gene family members are sentinels of nitrate availability. In this study, we present an additional role for NRT2.1 linked to plant resistance against pathogens. This gene antagonizes the priming of plant defenses against the bacterial pathogen Pseudomonas syringae pv tomato DC3000 (Pst). The nrt2 mutant (which is deficient in two genes, NRT2.1 and NRT2.2) displays reduced susceptibility to this bacterium. We demonstrate that modifying environmental conditions that stimulate the derepression of the NRT2.1 gene influences resistance to Pst independently of the total level of endogenous nitrogen. Additionally, hormonal homeostasis seemed to be affected in nrt2, which displays priming of salicylic acid signaling and concomitant irregular functioning of the jasmonic acid and abscisic acid pathways upon infection. Effector-triggered susceptibility and hormonal perturbation by the bacterium seem to be altered in nrt2, probably due to reduced sensitivity to the bacterial phytotoxin coronatine. The main genetic and metabolic targets of coronatine in Arabidopsis (Arabidopsis thaliana) remain largely unstimulated in nrt2 mutants. In addition, a P. syringae strain defective in coronatine synthesis showed the same virulence toward nrt2 as the coronatine-producing strain. Taken together, the reduced susceptibility of nrt2 mutants seems to be a combination of priming of salicylic acid-dependent defenses and reduced sensitivity to the bacterial effector coronatine. These results suggest additional functions for NRT2.1 that may influence plant disease resistance by down-regulating biotic stress defense mechanisms and favoring abiotic stress responses.
Visualizing the Genetic Landscape of Arabidopsis Seed Performance
Authors: Joosen Ronny Viktor Louis , Arends Danny , Willems Leo Albert Jan , Ligterink Wilco , Jansen Ritsert C. , Hilhorst Henk W.M. 
Published: December 2011

AbstractPerfect timing of germination is required to encounter optimal conditions for plant survival and is the result of a complex interaction between molecular processes, seed characteristics, and environmental cues. To detangle these processes, we made use of natural genetic variation present in an Arabidopsis (Arabidopsis thaliana) Bayreuth × Shahdara recombinant inbred line population. For a detailed analysis of the germination response, we characterized rate, uniformity, and maximum germination and discuss the added value of such precise measurements. The effects of after-ripening, stratification, and controlled deterioration as well as the effects of salt, mannitol, heat, cold, and abscisic acid (ABA) with and without cold stratification were analyzed for these germination characteristics. Seed morphology (size and length) of both dry and imbibed seeds was quantified by using image analysis. For the overwhelming amount of data produced in this study, we developed new approaches to perform and visualize high-throughput quantitative trait locus (QTL) analysis. We show correlation of trait data, (shared) QTL positions, and epistatic interactions. The detection of similar loci for different stresses indicates that, often, the molecular processes regulating environmental responses converge into similar pathways. Seven major QTL hotspots were confirmed using a heterogeneous inbred family approach. QTLs colocating with previously reported QTLs and well-characterized mutants are discussed. A new connection between dormancy, ABA, and a cripple mucilage formation due to a naturally occurring mutation in the MUCILAGE-MODIFIED2 gene is proposed, and this is an interesting lead for further research on the regulatory role of ABA in mucilage production and its multiple effects on germination parameters.
Usefulness of margin detection by digital dermoscopy in the traditional surgical excision of basal cell carcinomas of the head and neck including infiltrative/morpheaform type
Authors: CARDUCCI Mauro , BOZZETTI Marcella , DE MARCO Giuseppe , FOSCOLO Anna M. , BETTI Roberto 
Published: December 2011

AbstractIncomplete or suboptimal surgical excision of basal cell carcinoma of the head and neck is a relatively frequent occurrence. Methods of preoperative assessment of tumoral margins are therefore of paramount importance. The aim of this study was to compare the preoperative evaluation of margins with digital dermoscopy and clinical definition. One hundred and 12 patients with histologically confirmed basal cell carcinoma were selected for surgical excision. Subsequently, the margin of excision was determined by either clinical (45 patients) or dermoscopic evaluation (67 patients). After pre‐surgical clinical evaluation, 22% of histological specimens of excised basal cell carcinoma showed suboptimal margins of excision. Pre‐surgical dermoscopic evaluation had only 7% suboptimal excision. Preoperative digital dermoscopy is a better method to determine tumoral margins than clinical evaluation alone. Indeed, preoperative digital dermoscopy is an effective, simple, non‐invasive procedure for the pre‐surgical determination of margins.