bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcome of Pregnancy in Patients with Organic Heart Disease in Taiwan
Authors: Hsieh T'sang‐T'ang , Chen Kuang‐Chao , Soong Jin‐Hong 
Published: August 2010

AbstractA total of 122 pregnancies in 101 women with organic heart disease were reviewed. The incidence of organic heart disease in pregnant women was 0.25%. The ratio of rheumatic to congenital heart disease was 1.0 to 1.5. In the congenital heart disease group, IUGR was more frequent in the cyanotic group as were preterm births. Patients with cyanotic lesions had a significantly higher maternal mortality rate than those with acyanotic lesions. The cyanotic group without surgical correction had a significantly higher maternal mortality rate and more IUGR than those with correction. Congestive heart failure was the most common maternal complication, with a rate of 38.1%. The patients with good cardiac status control during pregnancy developed less IUGR, had fewer preterm births, less maternal morbidity and less maternal mortality than those in poor condition. Patients in functional classes I and II before pregnancy carried less risk of maternal morbidity than those in classes III and IV.
Y Ghromosome Analysis and Laparoscopic Surgery in XY Pure Gonadal Dysgenesis: A Case Report and a Review of Literature
Authors: Tsutsumi Osamu , Iida Taku , Hakuno Naomi , Sadatsuki Miyuki , Okai Takashi , Taketani Yuji , Nagafuchi Shigeo , Nakahori Yutaka 
Published: August 2010

AbstractDNA analysis and laparoscopic surgery were performed on a patient with 46, XY pure gonadal dysgenesis. Southern‐blot and polymerase chain‐reaction analyses revealed that she had no apparent deletion of the Y chromosome, including the SRY gene (sex‐determining region Y), suggesting that the patient might have some other abnormality. Since the risk of gonadal neoplasia in XY gonadal dysplasia is high, operative laparoscopy was performed to ensure that there was no malignancy in the patient. Laparoscopic surgery is recommended because of the amount of the surgery and the rapid postoperative recovery of the patient.
Synchronous Secretion of LH and Prolactin during the Normal Menstrual Cycle
Authors: Tennekoon Kamani H. , Lenton Elizabeth A. 
Published: August 2010

AbstractIntegrated hourly concentrations of day‐time prolactin and LH showed significant positive correlations (p<0.05‐0.001) on the day of the pre‐ovulatory mid cycle LH surge (n=3) and during the mid luteal phase (n=6) in a group of regularly cyclic women. No correlations between these two hormones were seen during any other stage of the cycle. Consistent significant correlations were not evident between prolactin and oestradiol, prolactin and progesterone, LH and oestradiol or LH and progesterone during any other stage of the cycle.
New Schedule of Intramuscular Iron Administration for Pregnant Women
Authors: Mahale Arun R. , Shah Suni] H. 
Published: August 2010

AbstractPregnant women between 14 and 20 weeks were randomly recruited in 2 groups, 50 to each. One group received iron with folic acid orally, other group was given 5 injections of iron dextran spaced 4 weekly. Mean haemoglobin was same for both the groups at the begining (p>0.05). At 36 weeks intramuscular group has shown statistically more haemoglobin rise than oral group (p<0.001). This new intramuscular schedule is found to be convenient, cheap and acceptable to pregnant women. It also assures atleast 5 antenatal checkups to a pregnant woman.
Luteinizing Hormone (LH) Surge in Patients Using Buserelin Spray during Ovarian Stimulation for Assisted Reproduction
Authors: Ho Pak‐Chung , Chan Yuen‐Fai , So Wai‐Ki , Yeung William S. B. , Chan Samuel T. H. 
Published: August 2010

AbstractThe incidence of luteinizing hormone surge was studied in patients who were downregulated with a short protocol of gonadotrophin releasing hormone agonist before ovarian stimulation for assisted reproduction. Buserelin nasal spray 100 μg was given 5 times daily from day 2 of the cycle, followed by ovarian stimulation with human menopausal gonadotrophin and follicle stimulating hormone from day 3 onwards. Of the 159 cycles studied, luteinizing hormone surge was detected in 9 cycles (5.7%). The occurrence of LH surge was usually (67%) but not always associated with a fall in serum oestradiol level before administration of human chorionic gonadotrophin. None of the patients developed luteinizing hormone surge after day 10. Even in patients without luteinizing hormone surge the serum luteinizing hormone levels on the day of administration of hCG were significantly higher than those on day 2 before administration of buserelin. It is concluded that a short protocol with intranasal buserelin 500 μg per day is inadequate to suppress endogenous luteinizing hormone surge.
Origin of CA125 and SCC Antigen in Human Amniotic Fluid*
Authors: Takeshima Nobuhiro , Suminami Yoshinori , Takeda Osamu , Abe Hiroaki , Kato Hiroshi 
Published: August 2010

AbstractLevels of CA125 and SCC antigen in amniotic fluids were examined in 26 cases. All samples showed high levels of CA125 and SCC antigen. Statistically significant decreases in CA125 (p<0.05) and increases in SCC antigen (p<0.01) from the second to the third trimesters were recognized.We focused on amnion cells as likely sources of the 2 tumor markers in amniotic fluid. Analysis of in vitro culture of amnion cells and amniotic membranes revealed an accumulation of CA125 and no accumulation of SCC antigen in the culture supernatant. A Northern blot analysis using a cDNA probe of SCC antigen ensured that there was no mRNA expression of SCC antigen in the amnion, the cord or the placenta. It is likely that the amnion is a major source of CA125 in amniotic fluid, and that the fetus is the origin of SCC antigen.
The Effect of Antenatal Administration of Solcoseryl on Hepatic Glycogen Synthesis in Rat Fetuses with Intrauterine Growth Retardation
Authors: Takahashi Hidehiko , Cheng Kuang‐Ming , Araki Tsutomu 
Published: August 2010

AbstractThe effect of antenatal solcoseryl administration on hepatic glycogen synthesis and storage was studied in normal developing and intrauterine growth‐retarded (IUGR) rat fetuses using biochemical analyses.The maximal effect of solcoseryl occurred 2 hours after administration. The glycogen content of the liver showed a significant increase in normal and IUGR fetuses with antenatal solcoseryl administration compared to their non‐solcoseryl counterparts (p<0.05). The activities of glycogen synthase enzymes, total and active forms, showed significant increases, at p<0.05 and p<0.005, respectively, in IUGR fetuses with antenatal solcoseryl administration. Active synthase also increased in normal fetuses with antenatal solcoseryl administration (p<0.05). There were no significant changes in the activities of glycogen phosphorylase enzyme.These findings suggest that antenatal solcoseryl administration stimulates hepatic glycogen synthesis and storage in IUGR rat fetuses, and thus might favorably influence the development of neonatal hypoglycemia.
Effects of Epidermal Growth Factor on Mouse Fetal Growth
Authors: Odaka Koji , Hiramatsu Yuji , Eguchi Katsuto , Kudo Takafumi 
Published: August 2010

AbstractThe effects of epidermal growth factor (EGF) on fetal growth were examined in mice. EGF is synthesized in large amounts by the mouse submandibular glands. On the 18th day of gestation, the body weight of fetuses whose mothers had undergone sialoadenectomy (excision of the submandibular glands) was significantly lower than that of controls. However, the maternal‐plasma EGF concentration was not significantly affected by sialoadenectomy. The body weight of fetuses whose mothers were injected with EGF for 7 days during pregnancy was significantly higher than that of controls. Sialoadenectomy altered the blood amino acid concentrations in adult female animals, especially the levels of leucine and isoleucine.These results suggest that EGF influences fetal growth mainly by regulating maternal nutrition.
The Influence of Semen Quality on the Kinetics of the Acrosome Reaction in Human Spermatozoa in vitro
Authors: Takahashi Kentaro , Kitao Manabu 
Published: August 2010

AbstractSpontaneous sperm acrosome‐reaction (AR) was examined in washed semen samples of 12 donors with proven fertility and 16 infertile patients who visited the Infertility Clinic of Shimane Medical University Hospital, using fluorescein‐labeled Concan‐avalin A lectin during incubation (37d̀C, 5% CO2) of up to 24 hours. In the fertile‐semen samples, a significant (p<0.05) increase of %AR was observed, with maximum values at 6 hours (or longer) of incubation. In the abnormal‐semen samples, 2 reaction patterns of %AR were observed: (1) a rapid significant (p<0.05) increase of %AR, with a maximum value at 3 hours of incubation; and (2) %AR<10% after 24 hours.The results are discussed and a new value (the GAR rate), which expresses the rate of spermatozoa getting acrosome reaction, is introduced. We conclude that abnormal semen quality leads to alterations in the pattern of the AR.
Endometriosis and Social Class: An Asian Experience
Authors: Arumugam Kulenthran , Welluppilai Sivanesh 
Published: August 2010

AbstractThe social class distribution in 147 patients confirmed to have endometriosis at laparoscopy was done to see if the disease was associated with affluence. Two hundred and eighty‐one patients confirmed not to have endometriosis was used as controls. The patients were derived from a background population for which the social class characteristics was known. Endometriosis was significantly (p<0.001) associated with social class 1 and 2. However there was no association between social class distribution and the severity of the disease developed.
Diagnostic Problems Relating to Uterine Cervical Polyps with Malignancy
Authors: Shiromizu Kenji , Ryou Eiji , Tsukagoshi Toshio , Nishimura Toshinobu , Takahashi Michiko , Matsuzawa Masumi 
Published: August 2010

AbstractIn order to clarify the diagnostic problems relating to, and the proper treatment of, uterine cervical polyps, 951 polyps were analyzed clinicopathologically. All polyps were examined histopathologically and divided into 2 groups: benign polyps (Group‐1), and polyps with neoplastic or malignant lesions (Group‐2). Polyp size and cervical cytology are not always reliable for predicting the correct diagnosis of neoplastic or malignant lesions. Colposcopic diagnostic accuracy was 56.3%, but increased to 75.0% when combined with cytology. Neoplastic or malignant lesions were found at both the cervical polyp and the cervix in 21 out of 24 Group‐2 patients (87.5%). These results suggest that in order not to miss rare neoplastic or malignant lesions in polyps and/or cervices, histopathological examinations of all polyps, aided by cervical cytology and colposcopic observation, are necessary.
Shared Antenatal Care between Family Health Services and Hospital (Consultant) Services for Low Risk Women
Authors: Chan F. Y. , Pun T. C. , Tse L. Y. , Lai P. , Ma H. K. 
Published: August 2010

AbstractFour thousand four hundred and seventy‐two patients were recruited into a project to test the efficacy of a Shared Care System in the management of low risk antenatal patients. The patients were scored according to a simple point scoring system. Three thousand three hundred and fourty‐seven (74.8%) were scored as low risk. Fifty point two percent (1,682) of these low risk patients received the conventional system of care and acted as controls; while 49.8% (1,665) received shared care, where they were seen jointly by midwives, general doctors and hospital specialists.It was found that with the use of shared care, there was a significant decrease in workload to the hospital specialty clinics. Not only was the antenatal diagnostic rate of intrauterine growth retardation (IUGR) significantly improved, but the mean gestations at which IUGR, malpresentations, and pregnancy induced hypertension were diagnosed were also significantly earlier. The number of antenatal cardiotocographs performed, as well as the number of hospital admissions and mean duration of stay were decreased in the study group. The overall cost savings to the hospital was calculated if the shared care system was generally adopted.
Relationship between the Prognosis of Conception and the Location of Pelvic Involvement in Endometriosis: Significance of the TOP (Tube, Ovary, Peritoneum) Classification
Authors: Kurata Suwako , Ishimaru Tadayuki , Masuzaki Hideaki , Yamabe Tooru 
Published: August 2010

AbstractTo determine the main factors that affect the prognosis for conception in endome‐triosis‐associated infertility, 99 infertile patients with laparoscopically confirmed endometriosis were classified according to the new TOP classification, which we have developed to evaluate the severity of endometriosis by site, i.e., fallopian tubes (T), ovaries (O) and the peritoneum (P). According to the TOP classification, a negative correlation between the pregnancy rate after treatment and the severity of lesions was noted in case of tubal and peritoneal involvement, but not when the ovaries were involved. If there was no tubal involvement or only unilateral tubal involvement, high pregnancy rates were achieved for patients with ovarian endometrioma (87%) and for those with partial or complete posterior cul‐de‐sac obliteration (83%). The results suggest that for endometriosis‐associated infertility, the treatment modality should be selected according to the severity of tubal involvement, which is considered to contribute to infertility more than ovarian or peritoneal lesions.
Pregnancy after Chemotherapy for Trophoblastic Diseases and Psychosomatic Developmentin the Progeny*
Authors: Suzuki Itsuko , Goto Setsuko , Yamada Ayako , Tomoda Yutaka 
Published: August 2010

AbstractWe treated 542 patients with trophoblastic diseases from 1965 through 1988, and succeeded in preserving fertility in 269 of them (240 cases of invasive mole and 29 cases of choriocarcinoma).Of the 269 patients, 198 (79.5%) conceived after completing treatment. A total of 396 pregnancies in these women resulted in 295 term live births (74.5%), 51 spontaneous abortions (12.9%), and 4 recurrences of moles (1.0%). Four cases (1.32%) of malformations were discovered. The growth conditions of 101 children born in 1976 or later were followed up until the age of 18 months. Their heights or weights did not differ significantly from those of children measured in national infantile‐growth surveys. The psychoneurological development of 54 children up to the age of 7 years who were studied by using infantile mental‐development questionnaires showed no marked mental retardation. Our results provide strong evidence of the safety of chemotherapy for the treatment of trophoblastic diseases.
Prostaglandins Biosynthesis in the Rabbit Uterine Cervix at Various Stages of Pregnancy
Authors: Okawa Toshiaki , Suzuki Yosuke , Hoshi Kazuhiko , Endo Chikara , Sato Akira , Nakanishi Hironori 
Published: August 2010

AbstractThe accumulation of prostaglandins (PGs: 6‐keto PGF1α, PGE2, PGF2α, and TXB2) elicited by A‐23187, a Ca2+‐ionophore, was studied in the uterine cervical tissue taken from non‐pregnant and pregnant (10th, 20th and 30th day of pregnancy) rabbits in vitro.At every stage of pregnancy, the accumulation of PGs levels increased as follows; 6‐keto PGF1α, PGE2, PGF2α and TXB2. Biosynthesis of each began to increase from the 20th day of pregnancy, and was significantly elevated at the 30th day. Especially, 6‐keto PGF1α and PGE2 were remarkably higher than PGF2α and TXB2 at term, and so they are thought to play a more important role in cervical dilation and ripening than the other PGs. Six‐keto PGF1α was significantly elevated on the 20th day, when other PGs had not yet began to increase. It is thus conceivable that PGI2 plays an important role in the predispositing of cervical ripening.
The Application of Immunotargeting into Cancer Chemotherapy with Carboplatin:in vitroandin vivoStudies
Authors: Ota Yoriko , Oehr Peter , Inaba Noriyuki , Takamizawa Hiroyoshi 
Published: August 2010

AbstractAnti‐tumor effects of the following 2 cis‐diammin (1, 1‐cyclobutandicarboxylato) platin II (carboplatin, Bristol‐Myers‐Squibb) conjugates were evaluated through bothin vitroand in vivo experiments: (1) carboplatin coupled with anti‐cytokeratin monoclonal antibody (MAb), TS1 via carboxymethyl dextran (carboplatin‐carboxymethyl dextran‐TSl), and (2) carboplatin‐carboxymethyl dextran‐avidin targeted to biotiny‐lated TS1. Using l‐ethyl‐3(3‐dimethylaminopropyl)‐carbodiimide andN‐hydro‐xysuccinimide, carboplatin was conjugated to carboxymethyl dextran, TS1, or avidin, at high molar ratios. The staining positivity of carboplatin‐carboxymethyl dextran‐TSl in indirect immunofluorescence was almost identical to that of the original MAb. The average dose of carboplatin given in each treatment was about 60% of a clinical dose. Regarding cytotoxicity, the free drug showed the strongest effect and the best dose‐dependency in cell lines: HeLa and ZR‐75‐1. Anin vivostudy giving carbo‐platin‐MAb conjugates or free drug to HeLa tumor bearing nude rats proved that the efficacy of carboplatin‐carboxymethyl dextran‐TSl in HeLa tumor was not greater than that of the free carboplatin.
Emergency Hysterectomy in Obstetrics: Review of 15 Years
Authors: Gupta U. , Ganesh K. 
Published: August 2010

AbstractA total of 140 patients underwent emergency obstetric hysterectomy at Smt Sucheta Kriplani Hospital, New Delhi, India, over a 15‐year period between 1976 to 1990. Rupture of uterus and obstetric hemorrhage were two major indications for obstetric hysterectomy. Maternal mortality occurred in 18 i.e. 12.8% of the cases. Hemorrhage was leading cause of maternal death. While major degree of placenta praevia was responsible for 39.3% of obstetric hemorrhage, it contributed to nearly 40% of maternal deaths. Fifty percent of placenta praevia cases had morbid adhesions of placenta, associated with previous cesarean section. Hence patients of previous cesarean section with placenta praevia should be operated by experienced obstetricians keeping plenty of blood ready.
Combined Intrauterine and Ovarian Pregnancy: A Case Report
Authors: Hirose Masaya , Nomura Tetsuya , Wakuda Kohji , Ishiguro Tatsuya , Yoshida Yoshinobu 
Published: August 2010

AbstractA case of combined intrauterine and ovarian pregnancy diagnosed by postoperative microscopic observations is reported in this paper. The patient was a 23‐year‐old, Japanese nulligravid female. On the 32 day after a previous D & C when normal chorionic tissues of very early gestation were obtained, she complained of severe lower abdominal pain. Immediate laparotomy revealed hemorrhaging from a hema‐toma‐like region on the surface of the left ovary, and partial resection of the left ovary was performed.The resected ovary was composed of an intact corpus luteum and another thin corpus luteum around a hematoma‐like region containing chorionic villi, confirming this case to be an ovarian pregnancy. Histological findings of chorionic villi of the ovary indicated that ovarian pregnancy took place during the same menstrual period as intrauterine pregnancy, and not after the prior D & C. From these observations, this case was diagnosed as a combined intrauterine and ovarian pregnancy.
Primary Clear Cell Adenocarcinoma of the Fallopian Tube with Brain Metastasis: A Case Report
Authors: Ryuko Kanji , Iwanari Osamu , Abu‐Musa Antoine , Fujiwaki Ritsuto , Kitao Manabu 
Published: August 2010

AbstractThe first reported case of cerebellar metastasis from primary clear cell adenocarcinoma of the fallopian tube is presented. Initially diagnosed as stage la, the patient underwent total abdominal hysterectomy, bilateral salpingo‐oophorectomy and omentectomy, followed by cisplatin‐based chemotherapy and whole pelvic irradiation. Thirty six months later multiple pulmonary metastases were detected that did not respond to chemotherapy. Later the patient presented with cerebellar metastasis. She received whole brain radiotherapy and steroids. The brain lesion partially responded and the patient's neurologic symptoms improved. Throughout there was no evidence of local recurrence. This case suggests that with the prolonged survival achieved by aggressive treatment occult brain metastases might become apparent.
Neonatal Narcotic Withdrawal in Hong Kong Chinese
Authors: Lam S. K. , To W. K. 
Published: August 2010

AbstractA retrospective case controlled study was carried out to study the neonatal characteristics, outcome and narcotic withdrawal syndrome in 51 neonates exposed to narcotic antenatally. The birth weight, head circumference and body length were significantly smaller in the study group while the incidence of prematurity (41%) and small‐for‐gestational age babies was increased (27.5%). Narcotic withdrawal occurred in 83% of narcotic exposed neonates. About half of them had onset of withdrawal symptoms within the first 24 hours. All of these newborns were treated by either phenobarbitone (45%), chlorpromazine (9.5%) or both (40.5%). The average duration of treatment was 15.7 days. There was one neonatal death due to in utero withdrawal and hypoxia, and another post‐neonatal death due to sudden infant death. Neonatal jaundice, necrotising enterocolitis, clinical sepsis and congenital syphilis were more common in the drug‐addicted group.
Extra Gonadal Germ Cell Tumours: Report of Two Cases
Authors: Kumar Lalit , Kumar Sunesh , Kamble R.M. , Sharma Suash 
Published: August 2010

AbstractExtra gonadal germ cell tumours (EGGCT) in women are rare. We report here two such patients. The clinical and laboratory features were — young age, 25 and 22 years, midline location (mediastinum, scalp), elevated tumour marker and normal ovaries on CAT scan. The histological subtype was embryonal carcinoma in both cases. Complete response (CR) was achieved with cisplatin based chemotherapy (CT). Both patients had return of normal ovarian functions and have delivered normal babies (1st patient one, 2nd patient 2 babies). Both remain asymptomatic and disease‐free at 30 + and 55 + months follow‐up.We conclude that patients with EGGCT after treatment with cisplatin based CT achieve CR with return of normal ovarian functions and prolonged survival.
Trabecular Bone in Long‐Term Depot‐Medroxyprogesterone Acetate Users
Authors: Virutamasen Pramuan , Wangsuphachart Somjai , Reinprayoon Damrong , Kriengsinyot Rosalin , Leepipatpaiboon Smai , Gua Chonticha 
Published: August 2010

AbstractA cross‐sectional study was designed to determine trabecular bone density in 75 long‐term depot‐medroxyprogesterone acetate (DMPA) users (> 3 yr) matched with non‐DMPA users by age, body mass index (18–25), limitation of age (< 45 yr), and body weight (< 60 kg). The long‐term DMPA cases were divided into 3 groups according to duration of injectable contraceptive use. Neither cases nor controls had a smoking or chronic alcohol consumption history. Cases and controls were matched by age. Trabecular bone of the femoral neck were assessed by X‐ray and interpreted by a single‐blinded radiologist. Trabecular bone patterns were graded according to Singh's Index. Blood collection for determination of estradiol, prolactin, calcium, phosphorus, and medroxyprogesterone acetate were performed in cases and controls. Venous blood was taken at twelfth week of injection of DMPA and within 5 days after menstrual bleeding cessation in the controls. Mean trabecular bone in the cases was 5.5 ± 0.6 (range 4–6). It was not statistically different from that in the controls (mean 5.5 ± 0.6, range 2—6). No statistically significant difference of serum, calcium, phosphorus, prolactin, and estradiol was seen in the cases when compared to controls at mid follicular phase of normal menstrual cycle. Serum MPA of individual case at twelfth week of injection was 4.1 ± 1.1 nmol/l. In conclusion, trabecular bone density in long‐term DMPA users were not statistically different from normal menstruating women who have not received injectable DMPA.