bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
Authors: Lu Kan V. , Zhu Shaojun , Cvrljevic Anna , Huang Tiffany T. , Sarkaria Shawn , Ahkavan David , Dang Julie , Dinca Eduard B. , Plaisier Seema B. , Oderberg Isaac , Lee Yohan , Chen Zugen , Caldwell Jeremy S. , Xie Yongmin , Loo Joseph A. , Seligson David , Chakravari Arnab , Lee Francis Y. , Weinmann Roberto , Cloughesy Timothy F. , Nelson Stanley F. , Bergers Gabriele , Graeber Thomas , Furnari Frank B. , James C. David , Cavenee Webster K. , Johns Terrance G. , Mischel Paul S. 
Published: August 2009

Abstract
Activating epidermal growth factor receptor (EGFR) mutations are common in many cancers including glioblastoma. However, clinical responses to EGFR inhibitors are infrequent and short-lived. We show that the Src family kinases (SFK) Fyn and Src are effectors of oncogenic EGFR signaling, enhancing invasion and tumor cell survival in vivo. Expression of a constitutively active EGFR mutant, EGFRvIII, resulted in activating phosphorylation and physical association with Src and Fyn, promoting tumor growth and motility. Gene silencing of Fyn and Src limited EGFR- and EGFRvIII-dependent tumor cell motility. The SFK inhibitor dasatinib inhibited invasion, promoted tumor regression, and induced apoptosis in vivo, significantly prolonging survival of an orthotopic glioblastoma model expressing endogenous EGFRvIII. Dasatinib enhanced the efficacy of an anti-EGFR monoclonal antibody (mAb 806) in vivo, further limiting tumor growth and extending survival. Examination of a large cohort of clinical samples showed frequent coactivation of EGFR and SFKs in glioblastoma patients. These results establish a mechanism linking EGFR signaling with Fyn and Src activation to promote tumor progression and invasion in vivo and provide rationale for combined anti-EGFR and anti-SFK targeted therapies. [Cancer Res 2009;69(17):6889–98]
Spatial Selective Attention Affects Early Extrastriate But Not Striate Components of the Visual Evoked Potential
Authors: Clark Vincent P. , Hillyard Steven A. 
Published: August 2009

Abstract
The effects of spatial selective attention on sensory processing in visual cortical areas were investigated by means of visual evoked potential (VEP) recordings and source localization techniques. Patterned stimuli were rapidly presented in random order to the left and right visual fields while subjects maintained central fixation and attended to one visual field at a time. Attended stimuli evoked enhanced P1 (100–130 msec) and N1 (120–200 msec) components of the VEP, whereas no effects of attention were observed on the C1 (50–100 msec) or P2 (200–240 msec) components. Spatiotemporal dipole modeling of the early VEP sources was carried out in relation to MRI-defined cortical anatomy. The dipolar generator of the C1 component was found to lie in calcarine cortex, the human homologue of area V1, whereas the attention-sensitive P1 generator was localized to ventral-lateral occipital cortex, within extrastriate area 19. These results support the hypothesis that spatial attention does not affect the initial activity evoked in area V1 but rather produces an enhancement within extrastriate visual areas of sensory signals arising from stimuli at attended locations.
Can We Lose Memory for Music? A Case of Music Agnosia in a Nonmusician
Authors: Peretz Isabelle 
Published: August 2009

Abstract
A follow-up study of a patient, C.N., with a severe auditory agnosia limited to music is reported. After bilateral temporal lobe damage, C.N., whose cognitive and speech functions are otherwise normal, is totally unable to identify or to experience a sense of familiarity with musical excerpts that were once highly familiar to her. However, she can recognize the lyrics that usually accompany the songs. She can also identify familiar sounds, such as animal cries. Thus, her agnosia appears highly specific to music. The functional nature of her deficit has been investigated through various perceptual tasks. She was initially severely impaired in processing pitch sequential structure but has always enjoyed normal processing of temporal structure. This selective disturbance for sequential pitch information can hardly account for her tune agnosia since processing of pitch variations has dramatically improved over the years. This recovery was not accompanied by any signs of improvement in music recognition, which remains extremely poor. Moreover, the fact that she has never been able to hum tunes from memory argues for a basic memory disturbance. Thus, she was tested here with a series of tests aiming at assessing her memory for familiar and unfamiliar music. The results show that C.N. has now recovered most perceptual skills and that despite a transient ability to exhibit knowledge of familiar music under restricted circumstances, she is markedly impaired at naming a tune and at judging its familiarity, as well as at memorizing familiar as well as novel music. This deficit was found to be not only modality-specific but music-specific as well. The findings suggest the existence of a perceptual memory that is specialized for music and that can be selectively damaged so as to prevent most forms of recognition ability.
Enhancement of Perceived Visual Intensity by Auditory Stimuli: A Psychophysical Analysis
Authors: Stein Barry E. , London Nancy , Wilkinson Lee K. , Price Donald D. 
Published: August 2009

Abstract
Judgments of the intensity of a stimulus are dependent on the level of central nervous system activity it generates. Generally, it is assumed that such judgments are based on activity along modality-specific pathways. Thus, visual intensity judgments would be based on unimodal visual activity. However, many neurons do not fit neatly within modality-specific categories, but can be influenced by more than one sensory modality. Often the “multisensory” effect is quite pronounced. If these multisensory neurons participate in such fundamental functions as perceived intensity, the presence of a nonvisual (i.e., auditory) cue may have a significant effect on the perceived intensity of a visual cue. The results of the present study were consistent with such a hypothesis. A brief, broad-band auditory stimulus was found to significantly enhance the perceived intensity of an LED. The effect was most pronounced at the lowest visual intensities, and was evident regardless of the location of the auditory cue. However, it was present only at the location of visual fixation. Yet, despite the significant influence of the auditory cue, and its differential effect at different visual intensities, a power function that maintains the proportionality among perceived visual intensities was retained.
A Neural Mechanism for Involuntary Attention Shifts to Changes in Auditory Stimulation
Authors: Schröger Erich 
Published: August 2009

Abstract
Involuntary switching to task-irrelevant sound change was studied by measuring event-related brain potentials (ERPs) and behavioral performance in a dichotic listening paradigm. Pairs of tones (S1 and S2) were presented and subjects were instructed to ignore S1 (delivered to the left ear) and to make a go/no-go response to the subsequent S2 (delivered to the right ear). On most trials, the task-irrelevant S1 was of standard frequency, but occasionally it deviated from the standard frequency either by a small or large amount. It was predicted that deviant stimuli were automatically detected and that they could involuntarily capture attention. If they lead to attention switching, less capacity should be available for the processing of target tones resulting in impaired processing of S2. As in many previous studies, deviant tones elicited the mismatch negativity (MMN), which is a component of the ERP indicating automatic change detection. Furthermore, targets preceded by a deviant tone elicited a smaller N1 wave and were detected less effectively than targets preceded by a standard tone. This impaired processing of targets following task-irrelevant changes occurred only with short S1–S2 intervals (Experiment I) but not with long ones (Experiment II). The results support a model claiming that the auditory system possesses a change detection system that monitors the acoustic input and may produce an attentional “interrupt” signal when a deviant occurs. The involuntary attentional capture caused by this signal leads to impoverished processing of closely succeeding stimuli.
Object-Centered Attentional Biases in the Intact Brain
Authors: Reuter-Lorenz Patricia A. , Drain Maxwell , Hardy-Morais Corinne 
Published: August 2009

Abstract
By simulating neglect-like effects in neurologically intact observers, we evaluated whether normal attentional allocation can be object centered. In a series of three experiments, observers detected a small gap on the left or right side of a configuration presented in either the left of right visual field. The figures were positioned so that on different trials, the left and right sides would fall in the same retinotopic, hemispatial, and environmental location. Thus, only the location with respect to an object-centered frame varied. We found opposite patterns of bias within each visual field: For figures in the left visual field, left gaps were detected better than right gaps, whereas in the right visual field the opposite pattern was evident. Control conditions indicate that these biases are not due to masking from eccentric contours and depend on the left and right segments being united into a single form. These results indicate that opposing orientational biases of the left and right hemispheres can operate within an object-centered frame in the normal brain. This evidence converges with patient studies and single-unit electrophysiology to reveal the importance of a relatively late, abstract locus for visual selection.
MRI-Based Topographic Parcellation of Human Neocortex: An Anatomically Specified Method with Estimate of Reliability
Authors: Caviness Verne S. , Meyer James , Makris Nikos , Kennedy David N. 
Published: August 2009

Abstract
We describe a system of parcellation of the human neocortex, based upon magnetic resonance images, that conserves the topographic uniqueness of the individual brain. Subdivision of the neocortex, according to this system, is based entirely upon the configuration of a specified set of cerebral landmarks, principally neocortical fissures. These are present but unique in the details of their configurations in each individual brain. We introduce here a computer-assisted algorithm that ensures that a skilled investigator can execute the parcellation routine in a manageable period of time. Secondly, we outline a comprehensive set of conventions that specify how the boundaries of parcellation units are defined by anatomic landmarks. The average interobserver agreement in voxel assignment to parcellation units within the overall neocortex was 80.2%.
A Specific Role for the Right Parahippocampal Gyrus in the Retrieval of Object-Location: A Positron Emission Tomography Study
Authors: Owen Adrian M. , Milner Brenda , Petrides Michael , Evans Alan C. 
Published: August 2009

Abstract
A plethora of studies, across many species, have now demonstrated that the hippocampal region plays a critical role in memory for spatial location. In spite of this compelling evidence, a number of important neuropsychological and neuroanatomical issues remain unresolved. In the present study, the functional anatomy of object-location memory was investigated using positron emission tomography (PET) with magnetic resonance imaging (MRI). Regional cerebral blood flow (rCBF) was measured while normal volunteers encoded, and then retrieved, the locations of eight familiar objects presented on a computer screen. In two analogous conditions, designed to fractionate object-location memory into its component processes, the subjects were simply required to encode, and then to retrieve, eight distinct locations represented by identical white boxes on the screen. An increase in rCBF was observed in the region of the right parahippocampal gyrus corresponding to entorhinal cortex when the Retrieving Location condition was subtracted from the Retrieving Object-Location condition. In contrast, when the Encoding Location condition was subtracted from the Encoding Object-Location condition, no significant rCBF changes were observed in the hippocampal region although significant activation was observed, bilaterally, in the anterior fusiform gyrus. In addition, the two encoding conditions activated left-hemisphere regions preferentially, whereas the two retrieval conditions activated right-hemisphere regions.
Together, these findings suggest that the human right hippocampal region is critically involved in retrieving information that links object to place. The secondary finding that encoding and retrieval appear to be lateralized to the left and right hemispheres respectively, is discussed with reference to current models of episodic memory, and alternative hypotheses are considered.
The Role of Neuronal Synchronization in Response Selection: A Biologically Plausible Theory of Structured Representations in the Visual Cortex
Authors: Roelfsema Pieter R. , Engel Andreas K. , König Peter , Singer Wolf 
Published: August 2009

Abstract
Recent experimental results in the visual cortex of cats and monkeys have suggested an important role for synchronization of neuronal activity on a millisecond time scale. Synchronization has been found to occur selectively between neuronal responses to related image components. This suggests that not only the firing rates of neurons but also the relative timing of their action potentials is used as a coding dimension. Thus, a powerful relational code would be available, in addition to the rate code, for the representation of perceptual objects. This could alleviate difficulties in the simultaneous representation of multiple objects. In this article we present a set of theoretical arguments and predictions concerning the mechanisms that could group neurons responding to related image components into coherently active aggregates. Synchrony is likely to be mediated by synchronizing connections; we introduce the concept of an interaction skeleton to refer to the subset of synchronizing connections that are rendered effective by a particular stimulus configuration. If the image is segmented into objects, these objects can typically be segmented further into their constituent parts. The synchronization behavior of neurons that represent the various image components may accurately reflect this hierarchical clustering. We propose that the range of synchronizing interactions is a dynamic parameter of the cortical network, so that the grain of the resultant grouping process may be adapted to the actual behavioral requirements.
It can be argued that different aspects of purposeful behavior rely on separable processes by which sensory input is transformed into adjustments of motor activity. Indeed, neurophysiological evidence has suggested separate processing streams originating in the primary visual cortex for object identification and sensorimotor coordination. However, such a separation calls for a mechanism that avoids interference effects in the presence of multiple objects, or when multiple motor programs are simultaneously prepared. In this article we suggest that synchronization between responses of neurons in both the visual cortex and in areas that are involved in response selection and execution might allow for a selective routing of sensory information to the appropriate motor program.
On Three Extant Sources of the Qur'an Transcribed in Hebrew
Authors: Paudice Aleida 
Published: August 2009

AbstractThis paper focuses on three extant sources of transcriptions of the Qur'an into Hebrew characters: manuscript Arab N. 5 found in the library of the Morgenländische Gesellschaft, the fragments of the Qur'an from the Cairo Genizah kept in the Cambridge University Library, and manuscript Vat. Ebr. 357 from the Vatican Library in Rome. The article focuses in particular on the Halle manuscript, a transcription of which is given in the appendix. The transcriptions of the Qur'an examined here show how each one was produced in a different milieu and served specific purposes. The fragments from the Cairo Genizah and the Halle manuscript served similar polemical purposes and were written in countries under Muslim rule, where knowledge of Arabic was important for the relations with the authorities and, certainly in Egypt, was a part of everyday life. By contrast, the Vatican manuscript places itself in a very different context, that of the cultural milieu of Jewish and Christian philosophers and scholars in the period of the Italian Renaissance.
Polish-Jewish Relations in the Kingdom of Poland During the First World War
Authors: Zieliński Konrad 
Published: August 2009

AbstractThe First World War, and particularly the occupation by the Central States, had a great impact upon the relations of the Jews with the Poles. During this period, Polish-Jewish relations deteriorated. The growing economic problems as well as the rise of the nationalistic mood accompanying the approaching independence supported this tendency. At the same time, the new social and political situation, the relative liberalism of the occupying forces, the free elections, the activities of self-government, and the emergence of the Polish autonomous institutions created new possibilities for Polish-Jewish cooperation. Yet more often they actually multiplied the areas of conflict. In the autumn of 1918 there had been pogroms in the Kingdom of Poland: Polish-Jewish relations apparently worsened in big cities as well as in the small towns and the countryside, which earlier had been relatively free from anti-Semitism.
Evaluation of AATSR and TMI Satellite SST Data
Authors: Reynolds Richard W. , Gentemann Chelle L. , Corlett Gary K. 
Published: August 2009

Abstract
The purpose of this paper is to investigate two satellite instruments for SST: the infrared (IR) Advanced Along Track Scanning Radiometer (AATSR) and the microwave (MW) Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI). Because of its dual view, AATSR has a potential for lower biases than other IR products such as the Advanced Very High Resolution Radiometer (AVHRR), while the tropical TMI record was available for a longer period of time than the global MW instrument, the Advanced Microwave Scanning Radiometer (AMSR).
The results show that the AATSR IR retrievals are good quality with biases lower than or as low as other satellite retrievals between 50°S and 50°N. Furthermore, the dual-view algorithm reduces the influence of aerosol contamination. However, the AATSR coverage is roughly half that of AVHRR. North of 50°N there appear to be biases and high variability in summer daytime retrievals, with smaller but consistent biases observed below 50°S. TMI data can significantly improve coverage offshore in regions where IR retrievals are reduced by cloud cover. However, TMI data have small-scale biases from land contamination that should be removed by modifying the land–sea mask to remove more coastal regions.
The Influence of Upper-Tropospheric Potential Vorticity on Convective Morphology
Authors: Schumann Melissa R. , Roebber Paul J. 
Published: August 2009

Abstract
Extensive research has illuminated the roles that buoyancy and vertical wind shear have in determining convective mode. The goal of this study is to examine synoptic forcing, as measured by the form of the waves on the dynamic tropopause and the strength of the resultant temperature advection, together with the environmental variables that are currently used to differentiate storm type. Logistic regression is used to make this discrimination and provides the preliminary results. First, multicellular lines and isolated rotating cells are associated with weaker synoptic forcing. Second, where an upper-level feature is present, multicellular convection (lines and clusters combined) is favored relative to isolated storms when there is stronger synoptic forcing, the shape of the upper-level potential vorticity (PV) feature is elongated, and there is a more southerly component in the deep-layer (0–6 km) mean wind. Third, when an upper-level feature is present and the convection is multicellular, clusters are favored relative to lines when the upper wave is not cut off (i.e., a wave structure promoting advection), provided that the deep-layer shear is not oriented at an optimal angle relative to a preexisting meridional boundary (as shown by prior research). Finally, if the convection is isolated, rotating storms may be favored for a broad area of PV advection, as measured by the relative equality of the zonal and meridional axes of the advection area, suggesting the importance of broader-scale destabilization. These findings are used to formulate testable hypotheses. Future model-based experiments using PV surgery or PV regression methods are proposed to clearly elucidate the dynamics behind these relationships.
Relationship between Precipitation Forecast Errors and Skill Scores of Dichotomous Forecasts
Authors: Tartaglione Nazario 
Published: August 2009

Abstract
In this paper, the sensitivities of the equitable threat score (ETS) and the true skill score (TSS), obtained with a 2 × 2 contingency table, to continuous precipitation forecast errors are investigated. Two idealized error models are adopted to describe the difference between forecasts and perfect observations. The observations consist of a time series generated by a multiplicative cascade model. The forecasts are constructed by adding the modeled errors to the observations. Two examples that are representative of two precipitation regimes are considered. Monte Carlo simulations of the modeled errors are performed to compute the score uncertainties.
Monotonic relationships between the precipitation forecast errors and the two skill scores are found. It is shown that the precipitation regime and the event frequency influence these relationships and the score uncertainties. The score uncertainties also depend on the forecast errors. Furthermore, it is shown that a relationship exists between the ETS and TSS when the forecast errors are very large. Results suggest that more information should be provided together with the scores and their uncertainties in order to provide a complete picture of the forecast performance.