bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Novel Acenaphthopyrazine Derivatives as Antitumor Agents Against MCF‐7 Cells: Molecular Synthesis, Optical Properties, and DNA‐Binding Studies.
Authors: Xing Junling , Cui Jingnan , Wang Shuang , Gao Jin , Zhang Zhichao 
Published: April 2012

AbstractThe highest antitumor activity against MCF‐/ cells is found for (IIIa).
ChemInform Abstract: Chalcogen‐Containing Heterocycles. Part 36. Tandem Addition—Cyclization of o‐Ethynylphenyl Isothiocyanates with N‐Nucleophiles: Difference of Cyclization Mode Between Primary and Secondary Amines.
Authors: Kaname Mamoru , Sashida Haruki 
Published: April 2012

AbstractThe reaction with primary amines gives benzothiazines (6‐exo‐dig cyclization products) exclusively.
ChemInform Abstract: Direct Enantioselective Three‐Component Kabachnik—Fields Reaction Catalyzed by Chiral Bis(imidazoline)‐Zinc(II) Catalysts.
Authors: Ohara Mutsuyo , Nakamura Shuichi , Shibata Norio 
Published: April 2012

AbstractA Zn—tridentate bis(imidazolinyl)pyridine complex efficiently catalyzes the asymmetric three‐component reaction of aromatic and aliphatic aldehydes, amines and diaryl phosphites to afford α‐aminophosphonates (IV) and (VIII) in high yields and moderate to high enantioselectivities (up to 93% e.e.).
ChemInform Abstract: Synthesis of α‐Arylphosphonates Using Copper‐Catalyzed α‐Arylation and Deacylative α‐Arylation of β‐Ketophosphonates.
Authors: Rout Laxmidhar , Regati Sridhar , Zhao Cong‐Gui 
Published: April 2012

AbstractDirect arylation of β‐ketophosphonates (I) and (V) with aryl iodides proceeds smoothly in the presence of Cu(I)—proline catalyst to afford α‐aryl‐β‐ketophosphonates (IV) and (VI), resp., in high yields.
ChemInform Abstract: N‐Phosphinyl Ureas: Synthesis, Characterization, X‐Ray Structure, and in vitro Evaluation of Antitumor Activity.
Authors: Gholivand Khodayar , Dorosti Nilufar , Ghaziany Fatemeh , Mirshahi Manouchehr , Sarikhani Sina 
Published: April 2012

AbstractThe compounds (III), (V), and (VII) are screened in vitro for their cytotoxic effects against the human cancer cell lines K562, MDA‐MB‐231, and HepG2.
ChemInform Abstract: Synthesis of [(Thiazol‐2‐ylamino)‐methylene]bisphosphonic Acids.
Authors: Chuiko A. L. , Filonenko L. P. , Lozinskii M. O. 
Published: April 2012

AbstractA method for the synthesis of N‐3 unsubstituted (thioureidomethylene)bisphosphonic acid (IV) and the subsequent Hantzsch condensation to thiazoles (VI) are described.
ChemInform Abstract: Briaroxalides: Novel Diepoxybriarane Diterpenes from an Okinawan Gorgonian Briareum sp.
Authors: Ota Koichiro , Okamoto Naoko , Mitome Hidemichi , Miyaoka Hiroaki 
Published: April 2012

AbstractSome briarane‐type diterpenes exhibit cytotoxic, antiviral, anti‐inflammatory, insecticidal and immunomodulating activities.
ChemInform Abstract: Lead Diversification. Application to Existing Drug Molecules: Mifepristone 1 and Antalarmin 8.
Authors: Masood M. Abid , Farrant Elizabeth , Morao Inaki , Bazin Marc , Perez Manuel , Bunnage Mark E. , Fancy Sally‐Ann , Peakman Torren 
Published: April 2012

AbstractMifepristone (I) and antalarmin (V) are used as substrates for the diversification of drug molecules using plate‐based chemical screens.
ChemInform Abstract: Stereoselective Synthesis of Functional Dehydrophenylalanine Derivatives from Novel β‐Chloroamino Esters.
Authors: Elemine Brahim Ould , Ennigrou Mohamed Rached , Besbes Rafaa 
Published: April 2012

AbstractFor the presented reaction the position of the compounds is limited to the N‐terminus of a peptide chain.
ChemInform Abstract: Free‐Radical Hydrothiolation of Glycals: A Thiol‐ene‐based Synthesis of S‐Disaccharides.
Authors: Staderini Samuele , Chambery Angela , Marra Alberto , Dondoni Alessandro 
Published: April 2012

AbstractIt is demonstrated that glycals undergo a photoinduced addition of glycosylthiyl radicals with complete regioselectivity.
ChemInform Abstract: Maplexins, New α‐Glucosidase Inhibitors from Red Maple (Acer rubrum) Stems.
Authors: Wan Chunpeng , Yuan Tao , Li Liya , Kandhi Vamsikrishna , Cech Nadja B. , Xie Mingyong , Seeram Navindra P. 
Published: April 2012

AbstractThe 5 new gallotannins, maplexins A‐E (Ia)‐(Ie), are isolated from red maple (Acer rubrum) stems along with 8 known gallic acid derivatives.
ChemInform Abstract: Building Bridges in Catalysis Science. Monodispersed Metallic Nanoparticles for Homogeneous Catalysis and Atomic Scale Characterization of Catalysts under Reaction Conditions
Authors: Gross Elad , Krier James M. , Heinke Lars , Somorjai Gabor A. 
Published: April 2012

AbstractReview: 36 refs.
ChemInform Abstract: Regioselectivity in the Ring Opening of Non‐Activated Aziridines
Authors: Stankovic Sonja , D'hooghe Matthias , Catak Saron , Eum Heesung , Waroquier Michel , Van Speybroeck Veronique , De Kimpe Norbert , Ha Hyun‐Joon 
Published: April 2012

AbstractReview: 81 refs.
ChemInform Abstract: Adverse Reactions and Drug—Drug Interactions in the Management of Women with Postmenopausal Osteoporosis
Authors: Rizzoli Rene , Reginster Jean‐Yves , Boonen Steven , Breart Gerard , Diez‐Perez Adolfo , Felsenberg Dieter , Kaufman Jean‐Marc , Kanis John A. , Cooper Cyrus 
Published: April 2012

AbstractReview: 133 refs.
Human CD4+ lymphocytes for antigen quantification: Characterization using conventional flow cytometry and mass cytometry
Authors: Wang Lili , Abbasi Fatima , Ornatsky Olga , Cole Kenneth D. , Misakian Martin , Gaigalas Adolfas K. , He Hua‐Jun , Marti Gerald E. , Tanner Scott , Stebbings Richard 
Published: April 2012

AbstractTo transform the linear fluorescence intensity scale obtained with fluorescent microspheres to an antibody bound per cell (ABC) scale, a biological cell reference material is needed. Optimally, this material should have a reproducible and tight ABC value for the expression of a known clinical reference biomarker. In this study, we characterized commercially available cryopreserved peripheral blood mononuclear cells (PBMCs) and two lyophilized PBMC preparations, Cyto‐Trol and PBMC–National Institute for Biological Standard and Control (NIBSC) relative to freshly prepared PBMC and whole blood samples. It was found that the ABC values for CD4 expression on cryopreserved PBMC were consistent with those of freshly obtained PBMC and whole blood samples. By comparison, the ABC value for CD4 expression on Cyto‐Trol is lower and the value on PBMC–NIBSC is much lower than those of freshly prepared cell samples using both conventional flow cytometry and CyTOF™ mass cytometry. By performing simultaneous surface and intracellular staining measurements on these two cell samples, we found that both cell membranes are mostly intact. Moreover, CD4+ cell diameters from both lyophilized cell preparations are smaller than those of PBMC and whole blood. This could result in steric interference in antibody binding to the lyophilized cells. Further investigation of the fixation effect on the detected CD4 expression suggests that the very low ABC value obtained for CD4+ cells from lyophilized PBMC–NIBSC is largely due to paraformaldehyde fixation; this significantly decreases available antibody binding sites. This study provides confirmation that the results obtained from the newly developed mass cytometry are directly comparable to the results from conventional flow cytometry when both methods are standardized using the same ABC approach. Published 2012 Wiley Periodicals, Inc.
Values for αβ and γδ T‐lymphocytes and CD4+, CD8+, and CD56+ subsets in healthy adult subjects: Assessment by age and gender
Authors: Andreu‐Ballester J. C. , García‐Ballesteros C. , Benet‐Campos C. , Amigó V. , Almela‐Quilis A. , Mayans J. , Ballester F. 
Published: April 2012

AbstractBackground:Normal reference values in healthy subjects for T‐lymphocytes for both types of receptors, αβ and γδ, and their subsets are yet to be defined. The aim of this study was to measure peripheral blood αβ and γδ total T‐lymphocytes and their subsets in a population of healthy subjects, in order to obtain valid reference values for studies in human pathology.Methods:We studied a total of 157 healthy subjects, 78 men and 79 women, establishing their levels of CD3+, CD4+, CD8+, CD56+, αβCD3+, αβCD3+CD4+, αβCD3+CD8+, αβCD3+CD56+, γδCD3+, γδCD3+CD4−CD8−, γδCD3+CD8+, and γδCD3+CD56+ T‐cells by flow cytometry. The T‐cell subsets were compared for different age and gender groups.Results:A significant decrease in CD3+, CD3+CD4+, CD3+CD4+ αβ, and CD3+ γδ T‐cells was observed in elderly subjects. CD3+, CD3+ αβ, and CD3+CD4+ αβ T‐cells increased in women, while CD3+CD56+ αβ T‐cells increased in men.Conclusions.These reference values could be useful in further research studies for assessing changes that occur in the different αβ and γδ T subsets in human pathology. © 2012 International Clinical Cytometry Society
Close association of olfactory placode precursors and cranial neural crest cells does not predestine cell mixing
Authors: Harden Maegan V. , Pereiro Luisa , Ramialison Mirana , Wittbrodt Jochen , Prasad Megana K. , McCallion Andrew S. , Whitlock Kathleen E. 
Published: April 2012

AbstractVertebrate sensory organs originate from both cranial neural crest cells (CNCCs) and placodes. Previously, we have shown that the olfactory placode (OP) forms from a large field of cells extending caudally to the premigratory neural crest domain, and that OPs form through cell movements and not cell division. Concurrent with OP formation, CNCCs migrate rostrally to populate the frontal mass. However, little is known about the interactions between CNCCs and the placodes that form the olfactory sensory system. Previous reports suggest that the OP can generate cell types more typical of neural crest lineages such as neuroendocrine cells and glia, thus marking the OP as an unusual sensory placode. One possible explanation for this exception is that the neural crest origin of glia and neurons has been overlooked due to the intimate association of these two fields during migration. Using molecular markers and live imaging, we followed the development of OP precursors and of dorsally migrating CNCCs in zebrafish embryos. We generated a six4b:mCherry line (OP precursors) that, with a sox10:EGFP line (CNCCs), was used to follow cell migration. Our analyses showed that CNCCs associate with and eventually surround the forming OP with limited cell mixing occurring during this process. Developmental Dynamics 241:1143–1154, 2012. © 2012 Wiley Periodicals, Inc.
Transgenic mouse analysis of Sry expression during the pre‐ and peri‐implantation stage
Authors: Silversides David W. , Raiwet Diana L. , Souchkova Ouliana , Viger Robert S. , Pilon Nicolas 
Published: April 2012

AbstractBackground: The SRY/Sry gene is expressed in pre‐Sertoli cells of the male genital ridge and functions as the mammalian testis determining factor (TDF). In addition, expression of SRY/Sry outside the genital ridge has been reported, including preimplantation embryos, although the functional significance of this is not well understood. Results: Using Cre‐mediated lineage studies and transgenic reporter mouse models, we now show that promoter sequences of human, pig and mouse SRY drive robust reporter gene expression in epiblast cells of peri‐implantation embryos between embryonic day (E) 4.5 and E6.5. Analysis of endogenous Sry expression revealed that linear transcripts are produced by means of multiple polyadenylation sites in E4.5 embryos. Within the epiblast, SRY reporter expression mimics the expression seen using a Gata4 reporter model, but is dissimilar to that seen using an Oct4 reporter model. In addition, we report that overexpression of mouse Sry in embryonic stem cells leads to down‐regulation of the core pluripotency markers Sox2 and Nanog. Conclusion: We propose that SRY/Sry may function as a male‐specific maturation factor in the peri‐implantation mammalian embryo, providing a genetic mechanism to help explain the observation that male embryos are developmentally more advanced compared with female embryos, and suggesting a role for SRY beyond that of TDF. Developmental Dynamics 241:1192–1204, 2012. © 2012 Wiley Periodicals, Inc.
The role of endosymbionts in the evolution of haploid‐male genetic systems in scale insects (Coccoidea)
Authors: Ross Laura , Shuker David M. , Normark Benjamin B. , Pen Ido 
Published: April 2012

AbstractThere is an extraordinary diversity in genetic systems across species, but this variation remains poorly understood. In part, this is because the mechanisms responsible for transitions between systems are often unknown. A recent hypothesis has suggested that conflict between hosts and endosymbiotic microorganisms over transmission could drive the transition from diplodiploidy to systems with male haploidy (haplodiploidy, including arrhenotoky and paternal genome elimination [PGE]). Here, we present the first formal test of this idea with a comparative analysis across scale insects (Hemiptera: Coccoidea). Scale insects are renowned for their large variation in genetic systems, and multiple transitions between diplodiploidy and haplodiploidy have taken place within this group. Additionally, most species rely on endosymbiotic microorganisms to provide them with essential nutrients lacking in their diet. We show that species harboring endosymbionts are indeed more likely to have a genetic system with male haploidy, which supports the hypothesis that endosymbionts might have played a role in the transition to haplodiploidy. We also extend our analysis to consider the relationship between endosymbiont presence and transitions to parthenogenesis. Although in scale insects there is no such overall association, species harboring eukaryote endosymbionts were more likely to be parthenogenetic than those with bacterial symbionts. These results support the idea that intergenomic conflict can drive the evolution of novel genetic systems and affect host reproduction.
One Ferromagnetic and Two Antiferromagnetic Dinuclear Nickel(II) Complexes Derived from a Tridentate N,N,O‐Donor Schiff Base Ligand: A Density Functional Study of Magnetic Coupling
Authors: Biswas Rituparna , Giri Sanjib , Saha Shyamal K. , Ghosh Ashutosh 
Published: April 2012

AbstractThree new dinuclear NiII complexes, [Ni2L2(NO3)2] (1), [Ni2L2(NO2)2] (2), and [Ni2L2(CH3COO)2(H2O)] (3), have been synthesized by using a tridentate Schiff base ligand, 2‐({[3‐(dimethylamino)propyl]imino}methyl)phenol (HL), along with a nitrate, nitrite, or acetate ion, respectively, as co‐ligand. These three complexes were characterized by spectral analysis, X‐ray crystallography, and variable‐temperature magnetic susceptibility measurements. The structural analyses revealed that the NiII ions are coordinated by the deprotonated chelating tridentate Schiff base and possess a distorted octahedral geometry in all three complexes. Complexes 1 and 2 are two di‐μ2‐phenoxido‐bridged species in which the nitrate and nitrite act as chelating co‐ligands. However, in complex 3, in which the acetate anion is monodentate, an additional water bridge is present along with two μ2‐phenoxido bridges making the complex a face‐sharing bi‐octahedron. Magnetic susceptibility measurements indicate an antiferromagnetic intradimer interaction in complexes 1 and 2 with J values of –20.34(5) and –25.25(4) cm–1, respectively, whereas complex 3 shows a dominant ferromagnetic exchange coupling with J = 19.11(9) cm–1. DFT calculations were performed, and the theoretically obtained J values of –19.99 (for 1), –24.19 (for 2) and 18.81 cm–1 (for 3) corroborate very well the experimental results. An attempt has also been made to correlate the effect of Ni···Ni distances and bridging Ni–O–Ni angles on the coupling constants of the NiII complexes through DFT calculations. The relative energy calculations show that the diphenoxido‐bridged complexes are stable at larger bridging angles, and consequently the coupling is antiferromagnetic, whereas with an additional water bridge, the formation of complexes with the Ni–O–Ni bridging angle in the ferromagnetic region is energetically profitable.
Influence of roasting conditions on fatty acids and oxidative changes of Robusta coffee oil
Authors: Budryn Grażyna , Nebesny Ewa , Żyżelewicz Dorota , Oracz Joanna , Miśkiewicz Karolina , Rosicka‐Kaczmarek Justyna 
Published: April 2012

AbstractThe aim of this study was to determine the influence of roasting conditions, including elevated humidity of air used in the process, on the properties of coffee oil. Beans of Robusta coffee were roasted in a laboratory convective roaster with a possibility of changing the temperature, humidity, and velocity of roasting air. Roasting temperatures from 190 to 216°C, air humidity from 0.07 to 1%, and air velocity of 0.5 and 1 m/s were used. Parameters analyzed in roasted beans were: oil content, fatty acids composition, including trans fatty acids using the GC/FID method and indicators of oxidation level, namely peroxide value and content of conjugated dienes and trienes. Also a thermal profile of oil with the use of the DSC method and finally the bean aroma were evaluated. For maintaining the maximal amount of PUFA, the most favorable roasting conditions were, either, roasting at relatively high temperature and short time, or roasting at low temperatures. Using moderately high temperature resulted in the highest oxidative changes, but on the other hand, the aroma of received beans presented the best sensory properties. For the best nutritional properties, the best roasting conditions were: temperature 210°C and 1% humidity content in roasting air at 1 m/s flow velocity. In such conditions roasted beans obtained a very high quality aroma, and the roasting time was relatively short.Practical applications: This research concerns the quality of oil obtained from roasted coffee beans. The composition of coffee oil changes slightly during roasting, but nevertheless it might be a source of peroxides and trans fatty acids in human diet. In industrial processing coffee oil is extracted from the remains left over from instant coffee production, and it is a popular agent for aromatizing food products. Thus, in this kind of processing, roasting conditions that limit the unfavorable changes of coffee oil should be used.
Effect of extra virgin olive oil on glycaemia in healthy young subjects
Authors: Oliveras‐López María‐Jesús , Innocenti Marzia , Martín Bermudo Francisco , López‐García de la Serrana Herminia , Mulinacci Nadia 
Published: April 2012

AbstractIn this approach we studied the glycaemia levels in 20 healthy young volunteers (26 ± 2 years), before and after a 30‐day intake of 50 mL of extra virgin olive oil (EVOO). We selected an oil rich in phenolic compounds (523 mg/L) with a high content of secoiridoidic derivatives (over 94.5%). The findings from our study reveal a significant decrease of glycaemia from 89.6 ± 6.8 to 82.7 ± 10.3 mg/dL (p<0.05), related to a long term daily intake of the study EVOO, as the only added fat. A significant increment of the HDL cholesterol, from 68.7 ± 11.5 to 75.2 ± 4.9 mg/dL, was also highlighted. Total cholesterol, LDL, VLDL, triglycerides, and blood pressure did not show significant variation after the 30‐day consumption of this EVOO. So far, few articles have described the influence of EVOO consumption, on plasma glucose levels in humans. This effect is observed in a group of healthy young humans. Moreover, we confirm that the level of free hydroxytyrosol (OH‐Tyr) in plasma increased up to fourfold (p<0.05) after the 30‐day intake of this EVOO. In addition, the excretion in urine of the main metabolite of OH‐Tyr, homovanillic acid (HVA), significantly increased.
Phenolic composition and antioxidant activity of Southern Italian monovarietal virgin olive oils
Authors: Gambacorta Giuseppe , Faccia Michele , Trani Antonio , Lamacchia Carmela , Gomes Tommaso 
Published: April 2012

AbstractThe phenolic composition and antioxidant activity of several monovarietal extra virgin olive oils used as blenders for the production of Collina di Brindisi protected designation of origin (PDO) oil, produced between December 2008 and January 2009 using two‐phases or three‐phases extraction system, were evaluated and compared with other manufacturer products designated as PDO. Oils were taken from the most representative ones industrial oil mills in the PDO geographical area. The parameters assessed were free acidity, peroxide value, K232 and K270 indices, organoleptic characteristics, total phenolic content (TPC), phenolic profile, and antioxidant activity coefficient (AAC). The phenolic contents and profiles of the monovarietal oils showed remarkable differences with respect to PDO oils. The variables that exerted a major influence on phenols concentration were the maturity degree of olives (December>January), followed by the extraction system (two‐phase>three‐phase), and place of growing. The Pearson r correlation index showed that AAC was positively correlated with TPC, p‐coumarate, and 3,4‐DHPEA‐EA, and negatively correlated with peroxide value.Practical applications: The results provide detailed information about: (i) the phenolic composition and the AAC of several monovarietal extra virgin olive oils used as blenders for the production of a PDO oil; (ii) the impact of genetic variability, place of growing, olive maturity degree, and extraction technology on oil phenol compounds; and (iii) the relationships among each phenolic compound and AAC, and their potential utilization as analytical index of antioxidant activity. It is important to study the phenolic compounds and antioxidant activity of monovarietal extra virgin olive oils used to produce PDO oil and to compare with the relative PDO samples in order to define a possible analytical tool able to verify what is stated in the label for consumer information and protection.
Fluvial carbon flux from headwater peatland streams: significance of particulate carbon flux
Authors: Pawson R. R. , Evans M. G. , Allott T. E. H. A. 
Published: April 2012

ABSTRACTThe extensive blanket peatlands of the UK uplands account for almost half of total national terrestrial carbon storage. However, much of the blanket peat is severely eroded so that the contemporary role of the peatland system in carbon sequestration is compromised by losses of organic carbon in dissolved (DOC) and particulate (POC) form in the fluvial system. This paper presents the first detailed assessment of dissolved and organic carbon losses from a severely eroded headwater peatland (River Ashop, South Pennines, UK). Total annual fluvial organic carbon losses range from 29–106 Mg C km,‐2 decreasing from the headwaters to the main catchment outlet. In contrast to less eroded systems fluvial organic carbon flux is dominated by POC. POC:DOC ratios decrease from values of 4 in the headwaters to close to unity at the catchment outlet. These results demonstrate the importance of eroding headwater sites as sources of POC to the fluvial system. Comparison with a range of catchment characteristics reveals that drainage density is the best predictor of POC:DOC but there is scatter in the relation in the headwaters. Steep declines in specific POC yield from headwater catchments are consistent with storage of POC within the fluvial system. Key to the significance of fluvial carbon flux in greenhouse gas budgets is understanding the fate of fluvial carbon. Further work on the fate of POC and the role of floodplains in fluvial carbon cycling is urgently required. Copyright © 2012 John Wiley & Sons, Ltd.