bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic and prognostic relevance of plain radiographs for periprosthetic joint infections of the hip: a literature review
Authors: Hofmann Ulf Krister , Eleftherakis Georgios , Migliorini Filippo , Fink Bernd , Mederake Moritz 
Published: June 2024

AbstractConventional radiography is regularly used to evaluate complications after total hip arthroplasty. In various recent consensus meetings, however, plain radiographs of a potentially infected hip joint have been judged as being only relevant to exclude diagnoses other than infection. Solid data on radiographic presentations of periprosthetic joint infection (PJI) are scarce. As a result, the prognostic value of radiological features in low-grade PJI remains uncertain. The present review article aims to present an overview of the available literature and to develop ideas on future perspectives to define the diagnostic possibilities of radiography in PJIs of the hip. The primary outcome of interest of this systematic review was the radiologic presentation of periprosthetic joint infections of the hip. As secondary outcome of interest served the sensitivity and specificity of the radiologic presentation of periprosthetic joint infections. Of the included articles, 26 were reviews, essays, or case reports and only 18 were clinical studies. Typical radiologic abnormalities of PJI were a periosteal reaction, a wide band of radiolucency at the cement–bone or metal–bone interface, patchy osteolysis, implant loosening, bone resorption around the implant, and transcortical sinus tracts. The frequency of their occurrence is still inadequately defined. A deeper understanding of the underlying causes and the relation between microorganisms to radiologic abnormalities can probably help clinicians in the future to diagnose a PJI. This is why further research shall focus on the radiographic features of PJI.
Alzheimer’s disease and drug delivery across the blood–brain barrier: approaches and challenges
Authors: Iqbal Iram , Saqib Fatima , Mubarak Zobia , Latif Muhammad Farhaj , Wahid Muqeet , Nasir Bushra , Shahzad Hamna , Sharifi-Rad Javad , Mubarak Mohammad S. 
Published: June 2024

AbstractAlzheimer's disease (AD) is a diverse disease with a complex pathophysiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation of hyper-phosphorylated tau as neurofibrillary tangles remain the core neuropathologic criteria for diagnosing Alzheimer's disease. Nonetheless, several recent basic discoveries have revealed significant pathogenic roles for other essential cellular and molecular processes. Previously, there were not so many disease-modifying medications (DMT) available as drug distribution through the blood–brain barrier (BBB) is difficult due to its nature, especially drugs of polypeptides nature and proteins. Recently FDA has approved lecanemab as DMT for its proven efficacy. It is also complicated to deliver drugs for diseases like epilepsy or any brain tumor due to the limitations of the BBB. After the advancements in the drug delivery system, different techniques are used to transport the medication across the BBB. Other methods are used, like enhancement of brain blood vessel fluidity by liposomes, infusion of hyperosmotic solutions, and local intracerebral implants, but these are invasive approaches. Non-invasive approaches include the formulation of nanoparticles and their coating with polymers. This review article emphasizes all the above-mentioned techniques, procedures, and challenges to transporting medicines across the BBB. It summarizes the most recent literature dealing with drug delivery across the BBB.
Efficacy of ivermectin and albendazole combination in suppressing transmission of lymphatic filariasis following mass administration in Tanzania: a prospective cohort study
Authors: Fimbo Adam M. , Mnkugwe Rajabu Hussein , Mlugu Eulambius Mathias , Kunambi Peter P. , Malishee Alpha , Minzi Omary M.S. , Kamuhabwa Appolinary A. R. , Aklillu Eleni 
Published: June 2024

Abstract
Background
Preventive chemotherapy with ivermectin and albendazole (IA) in mass drug administration (MDA) programs for all at-risk populations is the core public health intervention to eliminate lymphatic filariasis (LF). Achieving this goal depends on drug effectiveness in reducing parasite reservoirs in the community to halt transmission. We assessed the efficacy of ivermectin and albendazole in clearing microfilariae and circulating filarial antigens (CFA) following MDA.

Methods
This community-based prospective study was conducted in Mkinga district, Tanga region, Tanzania, from November 2018 to June 2019. A total of 4115 MDA-eligible individuals were screened for CFA using Filarial test strips. CFA positives were re-examined for microfilariae by microscopy. CFA and microfilariae positive individuals were enrolled and received IA through MDA campaign. The status of microfilariae and CFA was monitored before MDA, and on day 7 and six-month following MDA. The primary efficacy outcomes were the clearance rates of microfilariae on day 7 and six-months, and CFA at 6 months of post-MDA. The McNemar test assessed the proportions of microfilariae positive pre- and post-MDA, while Chi-square tests were utilized to examine factors associated with CFA status six months post-MDA.

Results
Out of 4115 individuals screened, 239 (5.8%) tested positive for CFA, of whom 11 (4.6%) were also positive for microfilariae. Out of the ten microfilariae-positive individuals available for follow-up on day 7, nine tested negative, yielding a microfilariae clearance rate of 90% [95% confidence interval (CI): 59.6–98.2%]. Participants who tested negative for microfilariae on day 7 remained free of microfilariae six months after MDA. However, those who did not clear microfilariae on day-7 remained positive six-months post-MDA. The McNemar test revealed a significant improvement in microfilariae clearance on day 7 following MDA (P = 0.02). Out of 183 CFA-positive individuals who were available at 6-month follow-up, 160 (87.4%) remained CFA positive, while 23 became CFA negative. The CFA clearance rate at 6 months post-MDA was 12.6% (95% CI: 8.5–8.5%). There was no significant association of variability in ivermectin plasma exposure, measured by maximum concentration or area under the curve, and the clearance status of microfilariae or CFA post-MDA.

Conclusions
Preventive chemotherapy with IA effectively clears microfilariae within a week. However, it is less effective in clearing CFA at six months of post-MDA. The low clearance rate for filarial antigenemia underscores the need for alternative drug combinations and additional preventive measures to achieve LF elimination by 2030.
Validation of the english version of the Multidimensional Mentalizing Questionnaire (MMQ)
Authors: Vera Cruz Germano , Rochat Lucien , Liberacka-Dwojak Magdalena , Wiłkość-Dębczyńska Monika , Khan Riaz , Khazaal Yasser 
Published: June 2024

Abstract
Background
Mentalizing refers to the ability to understand one’s own and others’ mental states. Mentalizing is considered a key component of social cognition and healthy personality development. A multinational assessment tools able to appraise the multidimensional and multifaceted aspects of this complex construct are needed.

Objective
The present study had two aims: (a) validate an English version of the Multidimensional Mentalizing Questionnaire (MMQ, 33 items) which was designed to assess mentalizing based on an integrated and multilevel model of mentalizing; (b) explore the correlational relationships between the six dimensions of the MMQ and a set of sociodemographic, psycho-cognitive, mental health, and socio-functional variables.

Methods
Overall, 1823 individuals (age: 19–76 years old [M = 45; SD = 16]; sex: male = 48.51%, female = 50.57%, non-binary = 0.9%) participated in an online survey. While the participants came from 77 different countries, most of them were residents in UK and USA (95%). Data analytics include confirmatory factorial analysis and Pearson correlations.

Results
The CFA results validated the factorial structure of a 28-items MMQ-English version, with acceptable goodness of fit indices. Regarding the psychometric properties, the MMQ-English version showed good internal reliability and significant positive correlation with another scale designed to assess an analogue construct showing a fair convergent validity. The findings indicated that males, individuals with lower levels of education, lower socio-economic status, depressed, and with a higher score of loneliness are significantly more likely to report poor mentalizing compared with females, individuals with higher education level, greater SES, happier, and with lower scores of loneliness.

Conclusion
The present study validated the English version of the MMQ.
Comparison of maternal-fetal attachment, anxiety, depression, and prevalence of intimate partner violence in Iranian women with intended and unintended pregnancy: a cross-sectional study
Authors: Maghalian Mahsa , Nikanfar Roghayeh , Nabighadim Mahsan , Mirghafourvand Mojgan 
Published: June 2024

Abstract
Background
Unintended pregnancies and intimate partner violence can adversely affect women, infants, and their psychological well-being. The study aimed to compare depression, anxiety, maternal-fetal attachment, and the prevalence of intimate partner violence between women with and without unintended pregnancies in Tabriz, Iran. The study sought to address the lack of research on this topic in the Iranian context.

Methods
This cross-sectional study was conducted on 486 pregnant women attending health centers in Tabriz City between 2022 and 2023. A cluster sampling method was utilized, and data were gathered through the administration of socio-demographic, Maternal Fetal Attachment, Edinburgh Postnatal Depression, World Health Organization Domestic Violence, and Pregnancy Anxiety instruments. A general linear model (GLM), controlling for potential confounding variables, was used to compare anxiety, depression, and maternal-fetal attachment between the two groups. Multivariable logistic regression analysis, also controlling for potential confounding variables, was employed to compare the prevalence of domestic violence between the two groups.

Results
The results of the adjusted GLM indicated that women with unintended pregnancies had significantly lower maternal-fetal attachment (Adjusted mean difference (AMD):-9.82, 95% CI:-12.4 to -7.15 ; p < 0.001)), higher levels of depression (AMD: 2.89; CI: 1.92 to 3.86 ; p < 0.001), and higher levels of anxiety (MD: 5.65; 95% CI: 3.84 to 7.45; p < 0.001) compared to women with intended pregnancies. During pregnancy, 40% of women with unintended pregnancies and 19.2% of women with intended pregnancies reported experiencing at least one form of physical, sexual, or emotional violence. The results of the adjusted multivariable logistic regression revealed that women with unintended pregnancies had a significantly higher odds of experiencing emotional violence (adjusted odds ratio [aOR]: 2.94; 95% CI: 1.64 to 5.26; p < 0.001), sexual violence, (aOR: 2.25; 95% CI: 1.32 to 3.85; p = 0.004), and physical violence (aOR: 2.38; 95% CI: 1.50 to 3.77; p < 0.001) compared to women with intended pregnancies.

Conclusions
The study found that women with unintended pregnancies had lower levels of maternal-fetal attachment, higher levels of anxiety and depression, and a high prevalence of intimate partner violence, including physical, sexual, and emotional violence, compared to women with intended pregnancies. These results emphasize the importance of implementing policies aimed at reducing unintended pregnancies.
Bone-organ axes: bidirectional crosstalk
Authors: Deng An-Fu , Wang Fu-Xiao , Wang Si-Cheng , Zhang Ying-Ze , Bai Long , Su Jia-Can 
Published: June 2024

AbstractIn addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteokines). This reciprocal influence extends to these organs modulating bone homeostasis and development, although this aspect has yet to be systematically reviewed. This review aims to elucidate this bidirectional crosstalk, with a particular focus on the role of osteokines. Additionally, it presents a unique compilation of evidence highlighting the critical function of extracellular vesicles (EVs) within bone-organ axes for the first time. Moreover, it explores the implications of this crosstalk for designing and implementing bone-on-chips and assembloids, underscoring the importance of comprehending these interactions for advancing physiologically relevant in vitro models. Consequently, this review establishes a robust theoretical foundation for preventing, diagnosing, and treating diseases related to the bone-organ axis from the perspective of cytokines, EVs, hormones, and metabolites.
Virtual noncontrast images reveal gouty tophi in contrast-enhanced dual-energy CT: a phantom study
Authors: Khayata Karim , Diekhoff Torsten , Mews Jürgen , Schmolke Sydney , Kotlyarov Maximilian 
Published: June 2024

Abstract
Background
Dual-energy computed tomography (DECT) is useful for detecting gouty tophi. While iodinated contrast media (ICM) might enhance the detection of monosodium urate crystals (MSU), higher iodine concentrations hamper their detection. Calculating virtual noncontrast (VNC) images might improve the detection of enhancing tophi. The aim of this study was to evaluate MSU detection with VNC images from DECT acquisitions in phantoms, compared against the results with standard DECT reconstructions.

Methods
A grid-like and a biophantom with 25 suspensions containing different concentrations of ICM (0 to 2%) and MSU (0 to 50%) were scanned with sequential single-source DECT using an ascending order of tube current time product at 80 kVp (16.5–220 mAs) and 135 kVp (2.75–19.25 mAs). VNC images were equivalently reconstructed at 80 and 135 kVp. Two-material decomposition analysis for MSU detection was applied for the VNC and conventional CT images. MSU detection and attenuation values were compared in both modalities.

Results
For 0, 0.25, 0.5, 1, and 2% ICM, the average detection indices (DIs) for all MSU concentrations (35–50%) with VNC postprocessing were respectively 25.2, 36.6, 30.9, 38.9, and 45.8% for the grid phantom scans and 11.7, 9.4, 5.5, 24.0, and 25.0% for the porcine phantom scans. In the conventional CT image group, the average DIs were respectively 35.4, 54.3, 45.4, 1.0, and 0.0% for the grid phantom and 19.4, 17.9, 3.0, 0.0, and 0.0% for the porcine phantom scans.

Conclusions
VNC effectively reduces the suppression of information caused by high concentrations of ICM, thereby improving the detection of MSU.

Relevance statement
Contrast-enhanced DECT alone may suffice for diagnosing gout without a native acquisition.

Key points
• Highly concentrated contrast media hinders monosodium urate crystal detection in CT imaging
• Virtual noncontrast imaging redetects monosodium urate crystals in high-iodinated contrast media concentrations.
• Contrast-enhanced DECT alone may suffice for diagnosing gout without a native acquisition.

Graphical Abstract
Methamphetamine and carbon monoxide co-toxicity: an unusual case report and literature review
Authors: Ata Uğur , Çelik Cemil , Saka Naile Esra 
Published: June 2024

Abstract
Background
Comprehending the toxic effects of substances co-detected in bodily fluids presents a formidable challenge. The combined toxic effect of carbon monoxide and methamphetamine remains a rarely discussed issue within the realm of scholarly literature. The main objective of this research is to delve into the potential intricacies of death mechanisms, unraveling the profound impact of both CO and methamphetamine on the heart.

Case presentation
The cause and mechanism of death of a young man with toxic levels of CO–Hb and low-dose methamphetamine in his bloodstream were discussed in conjunction with the literature in this study. Methamphetamine levels of 30 ng/mL (0.03 mg/L) and 25.8% CO–Hb were detected in the blood of a 25-year-old individual who was found dead and without any disease.

Conclusions
Although the amounts of methamphetamine and CO–Hb in the blood were not in the deadly range, it was determined that death occurred as a result of the combined action of these substances. In the present case, it was considered that death occurred as a result due to the combined cardiac effect of methamphetamine and CO, before the lethal blood CO level was reached.
Impact of melon seed oil cake with different particle sizes on bread quality
Authors: Zhang Guoqiang , Li Ziqian 
Published: June 2024

AbstractMelon seed oil cake (MSOC), as the secondary by-product from melon seed oil pressing process, has high potential nutritional value. The aim of this study was to assess the effect of incorporating MSOC as wheat flour substitute and its particle size on bread quality; three particle size fractions of MSOC (coarse, medium, and fine) and two substitution levels (3 and 6%, w/w) were employed. Functional properties and colour of different particle sizes of MSOC were assessed, and the physical properties of bread made with MSOC were explored and compared to control bread (100% wheat flour). Results showed that bread made with 3% MSOC had relatively satisfactory quality in terms of specific volume (2.64–2.86 mL/g), hardness (14.31–15.04 N) compared to the control bread (specific volume 2.79 mL/g and hardness 13.87 N). Bread made with fine particle size of MSOC (2.64 mL/g and 15.04 N at 3% substitution level; 2.44 mL/g and 16.03 N at 6% substitution level) had lower specific volume and higher hardness values than the bread made with medium (2.80 mL/g and 14.31 N at 3% substitution level; 2.50 mL/g and 15.50 N at 6% substitution level) and coarse (2.86 mL/g and 14.72 N at 3% substitution level; 2.52 mL/g and 15.12 N at 6% substitution level) particle sizes of MSOC. These results indicate that using 3% MSOC with larger particle size could be more suitable for making bread with relatively satisfactory quality. Overall, MSOC could be re-introduced into food chain as ingredient for bread production, which offers possibilities to develop novel sustainable foods. Future work will be conducted on sensory quality and consumer acceptance to provide a desirable quality of bread.
Graphical Abstract
Harnessing digital technologies for triple bottom line sustainability in the banking industry: a bibliometric review
Authors: Garg Megha , Kumar Parveen 
Published: June 2024

AbstractThe interconnection between the consequences of digital technologies and their impact on triple bottom line sustainability in the banking industry has emerged as a dynamic, multidisciplinary, and eclectic research area of global significance. Nevertheless, applying a systematic literature network analysis in this field has not yet been attempted. Therefore, this paper aims to investigate academic research by integrating different knowledge systems. To conduct this comprehensive analysis, this study employed the contextualized systematic literature review and bibliometric approaches method to make inferences from 154 publications obtained from the Scopus and Web of Science databases for the years 2012–2024 by using the biblioshiny tool. The study’s findings exhibited a noticeable upsurge in research trends in the last five years. With 64 publications, 2023 was the most productive year, and 2018 had the most influence with 188 citations. China, Italy, Spain, Egypt, and Malaysia were the most productive countries regarding citation performance. This study highlights the counterintuitive connection between digitalization, financial inclusion, sustainability, fintech, and sustainable development by providing support with recent literature to reflect the current developments in the field. The themes encountered here are crucial for regulators and practitioners who aim to capitalize on the mutually reinforcing nature of the two phenomena in the banking industry.
Implementation of universal germline testing in underserved patients with young onset gastrointestinal cancer.
Authors: Ludford Kaysia , Awad Elias , Lankford Anjali R. , Ma Hilary Yu-heng , You Y. Nancy 
Published: June 2024

10602 Background: Universal germline testing (UGT) in solid cancer patients increases the detection of pathogenic germline variants (PGVs) over guideline-based testing. There is a rising incidence of young onset (YO) gastrointestinal (GI) cancers (50 years and under). PGV rates in this population can be as high as 20%, highlighting the benefit of UGT. Underserved populations experience significant disparities in germline testing. The primary aim of this study is to evaluate rates of germline testing among patients with young onset (YO) GI cancers in a large safety net population and identify barriers and facilitators of testing in order to improve the process. Methods: In this retrospective study, we identified 202 patients ages 18-50 diagnosed with GI cancers between January 2019 and December 2022 at the Lyndon B. Johnson Hospital. Demographic and clinical data were collected and the rate, outcome and process of standard of care germline testing evaluated. Paired T-tests were used to identify factors associated with timeliness and completion of germline. Results: The majority of patients had colorectal (68%) followed by gastro-esophageal cancers (16%). Median age at diagnosis was 42 years. One third were diagnosed with stage IV disease. Half of all patients were recipients of financial assistance based on household income less than 150% of the Federal Poverty Level. Spanish was the primary language spoken by 58% of patients. Among all patients, 148 (73%) were referred to a genetics counselor with germline testing offered in 111 (55%) and completed in 99 (49%). PGVs were identified in 17% of patients tested while variants of uncertain significance were found in 19%. Patients with colon cancer (p<0.001), microsatellite instability on immunohistochemistry (p<0.001), and those with a first-degree relative with cancer (p<0.001) were more likely to complete genetic testing. The average time from initial oncology visit to genetics referral was 20 weeks while that from referral to genetics appointment was 22.5 weeks. The average time from genetics appointment to completion of testing was 14.5 weeks. Patients with private insurance had a significantly shorter time to genetics referral (p<0.05) while English-speakers had a longer time from referral to initial genetics appointment (p 0.019) and to completion of testing (p 0.044). Uninsured patients had significantly lengthier times to test completion (p 0.013). Conclusions: PGVs were detected in 17% of patients with YO GI cancers. Along the genetics services care delivery continuum, patient selection for genetic counselor referral, uptake of genetic testing and timeliness of testing were identified as key barriers to germline testing. Given the high detection rate and barriers to testing identified in this underserved population, we have designed a multilevel intervention aimed at optimizing the implementation of UGT in patients with YO GI cancers.