bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomimetic Breakthrough: Enhancing Tendon Repair with dAM- TDSCs
Authors: Mao Xufeng , Wang Yulong , Zhang Xiqian , Yao Zheyu , Yuan Zheyang , Yao Liwei , Wang Leining , Mao Haijiao 
Published: February 2025

Abstract

Background
Adhesions and poor healing are major complications after Achilles tendon injury, and there is no effective solution to this problem. The purpose of this study is to determine whether the biomimetic peritoneurosis can solve the above problems in the process of Achilles tendon healing;
Methods: Our studies investigated the adhesion and proliferation of tendon-derived stem cells (TDSCs) on dAM in vitro, as well as their tenogenic differentiation. The effects of Achilles tendon rupture on tendon regeneration were assessed in vivo by using an Achilles tendon rupture model in rats; Finally, from in vitro mRNA transcriptome sequencing combined with in vivo Achilles tendon protein to omics analysis to explore the repair mechanism of Achilles tendon rupture. Student's t-tests were used to assess the significance of observed differences between the two experimental groups. Multiple groups were compared using one-way analysis of variances (ANOVAs), followed by post hoc Bonferroni comparisons.
Results: The main findings of this study are that cell adhesion, proliferation, and differentiation of TDSCs were enhanced by dAM. Implanted dAM + TDSCs significantly accelerated tendon regeneration in vivo. In addition, extracellular matrix-related differential genes and proteins were screened by mRNA transcriptometry in vitro and proteomic analysis of Achilles tendon in vivo, and ERK signaling pathway was further explored to participate in the repair of Achilles tendon rupture.
Conclusions: The dAM-TDSCs composite biomimetic peritendinous membrane material can effectively promote the healing of Achilles tendon. It provides a new direction for the development of biomimetic peritendinous membrane materials.
Power generation dispatching and risk analysis of the Qingjiang cascade hydropower stations under climate change
Authors: Li Yinghai , Huang Rubao , Meng Hongchi , Soomro Shan-e-hyder , Zhang Hairong , Guo Jiali , Li Changwen , Wang Yongqiang 
Published: February 2025

ABSTRACT

Climate change alters river runoff regimes, affecting the safe operation of hydropower stations. This study proposed an optimization scheduling and risk analysis framework for cascade hydropower under climate change using the Qingjiang cascade hydropower stations as a case study. The framework has three stages. Firstly, a hydrological model coupling GCMs with SWAT under CMIP5 scenarios is established to predict future runoff. Secondly, cascade hydropower optimization scheduling under climate change is performed using the POA (Progressive Optimization Algorithm). Thirdly, a risk assessment index system is established, including risks of insufficient power generation, insufficient output, and water abandonment. The POMR (Probability Optimization Method for the Risk) is applied to calculates power scheduling risks. Results show that the simulated annual average runoff at Changyang Station increases by 6.0, 8.7, and 13.2% under the RCP2.6, RCP4.5, and RCP8.5 scenarios, respectively. Annual power generation for the Qingjiang cascade is projected to rise by 6.2–16.5%, with increases of 5.2–12.9% during flood seasons and 7.5–19.9% in non-flood seasons. Comprehensive risk rates decline to 0.1767, 0.1706, and 0.1630 across the scenarios. This research provides scientific and technical support for managing water resources and operating the Qingjiang cascade under climate change.
Impact of types of water source on pipeline corrosion: a comprehensive electrochemical and microscopic analysis
Authors: Lv Zhisheng , Song Guanyong , Zhao Shanshan , Jin Binbin , Xiao Hua , Guo Yabin , Wang Ao , Xu Hang 
Published: February 2025

ABSTRACT

Switching water sources is essential for effective water resource management and pipeline maintenance, ensuring water supply stability and reducing reliance on a single source. However, improper water source selection can disrupt the chemical balance within pipelines and accelerate corrosion. This study simulated the process of switching water sources and employed electrochemical analysis, such as scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy, to investigate the impact of water source switching on pipeline corrosion. During the initial switching phase, severe pipeline corrosion was observed, along with significant variations in water quality indicators that substantially influenced corrosion. Electrochemical analysis revealed a decrease in pipeline open circuit potential and a negative shift in the polarization curve, indicating an increased tendency for corrosion. Corrosion could be relieved as the pipeline adapted to the new water quality. Microscopic analysis demonstrated that switching water sources affected the structure and stability of the corrosion product film. Investigations into different water source switching ratios indicated that corrosion levels should not be evaluated based on a single parameter; an appropriate blend of water sources is necessary to effectively mitigate corrosion. This study provides valuable insights for water source management, pipeline maintenance, and efficient water supply strategies.
Non-Bacterial Thrombotic Endocarditis in Lung Cancer: A Systematic Review
Authors: Kamel Maikel , Hussain Fahad , Leung Christian , Paracha Awais , Sathe Pranav , Jassal Ajay , Huba Mahalia , Durrani Umar , Ammari Nadim , Copeland-Halperin Robert S. , Seetharamu Nagashree 
Published: February 2025

Introduction:
Nonbacterial Thrombotic Endocarditis (NBTE) is a rare condition
characterized by aseptic vegetations of the heart valves, predisposing to valvular dysfunction
and end-organ infarction. Lung Cancer (LC) is amongst the most common malignancies associated
with NBTE.

Methods:
PubMed/MEDLINE was searched from database inception until January 2024, pairing
“Non-Bacterial Thrombotic Endocarditis (NBTE) and related terms with “Lung Cancer”(
LC). Reports were included if patients had both NBTE and lung cancer. The risk of bias
was assessed using Mixed Methods Analysis Testing (MMAT).

Results:
32 patients with an average age of 59y +/- 11.6 were included from 31 peer-reviewed
publications, with significant findings as below:
• The majority (47%) of patients were admitted with stroke.
• The most commonly affected valve was aortic (51%), followed by mitral (43%), and
tricuspid (5%).
• At diagnosis of NBTE, 86% of patients had stage IV cancer.
• Multi-organ infarct was common (61%), with the brain most often affected (40%).
• Treatment of NBTE included antibiotics (86%), anticoagulation (50%), and cardiac
surgery (6%).
• Treatment of LC included traditional chemotherapy (30.7%), radiation (16%), tyrosine
kinase inhibitors (11.5%), lobectomy (6%), and immunotherapy (3.8%).
• Overall mortality rate was 77%.
• Mortality rate was 38% in patients treated with chemotherapy and 91% in patients who
did not receive chemotherapy.
• Mortality rate stratified by anticoagulant: unfractionated heparin (85.7%), DOAC
(75%), and LMWH (20%).

Conclusion:
High clinical suspicion for NBTE in patients presenting with LC and thromboembolic
phenomena can lead to changes in treatment and improved clinical outcomes.
Plants as Medicine for Autism: Reviewing the Evidence for Phytopharmaceuticals for ASD
Authors: Al Noman Abdullah , Flora Sanzida Alam , Deb Tonni Susmita , Barua Cinmoy , Kumar Nath Anik , Bristy Kaniz Fatema , Ahmad Iftakhar , Pathak Rashmi , Sharma Himanshu 
Published: February 2025

Abstract:
A complicated neural developmental condition, autism spectrum disorder (ASD) is
marked by difficulties with social interaction, communication, and repetitive behaviours. There is
increasing interest in complementary and alternative medicines, including medicinal plants, to
treat the symptoms of ASD as incidence rates rise globally. This thorough analysis looks at the
available data supporting a range of plant-based ASD control strategies. We assess important
therapeutic herbs, including Curcuma longa (turmeric), Bacopa monnieri, Ginkgo biloba, Cannabis
sativa, and Camellia sinensis (green tea), and talk about their bioactive components, possible
modes of action, and clinical results. Several plants have neuroprotective, anti-inflammatory, and
antioxidant qualities that may work against the underlying pathophysiological mechanisms of
ASD. The body of data is still small, even if certain clinical studies yield encouraging results,
especially in the areas of behaviour modification and symptom treatment. The diverse character
of ASD, small sample sizes, and methodological problems are study challenges. We also talk
about the restrictions and security issues surrounding herbal remedies. Potential directions for
phytopharmaceutical design for ASD in the future, such as combination therapy, enhanced delivery
strategies, and the requirement for more extensive, carefully planned clinical studies. The potential
of medicinal plants in treating ASD is highlighted in this review, but it also emphasizes the
urgent need for further thorough study to confirm their efficacy and safety.
A Potential Regulatory Network of Selected Human Erythrocytic miRNAs with Plasmodium falciparum 3D7 mRNAs: A Computational Analysis
Authors: Joshi Urja , Motwani Harsha , Jani Dhara , George Linz-buoy , Highland Hyacinth 
Published: February 2025

Background:
miRNAs are small non-coding conserved RNA molecules (18-24 nts) that act as crucial gene regulators via post-transcriptional/translational modifications through in-teracting with the respective mRNAs during various pathophysiological conditions. Recent re-search has suggested that non-coding RNAs, particularly miRNAs, can be passed from one spe-cies to another to regulate gene expression. Since miRNA-mediated gene regulation has not yet been found in Plasmodia, it is hypothesized that erythrocytic miRNAs from Plasmodium falcipa-rum (P. falciparum) could potentially migrate from the cytoplasm to the parasitophorous vacuole developed intracellularly by the parasite to regulate its transcriptome.

Objective:
The objective of this study is to investigate the role of trans-kingdom interactions in host-parasite dynamics and their implications for malaria infection.

Methods:
Using the trans-kingdom target gene prediction tool, psRNA target server, a total of 15 human erythrocytic miRNAs from 12 distinct families were selected and obtained from miRBase to find potential P. falciparum candidate genes. This study utilized ShinyGO (version 0.80) for gene enrichment analysis with statistical analysis of the selected features. The PPI-network analysis was performed using the Maximal Clique Centrality (MCC) approach, along with the CytoHubba plugin for identifying hub nodes. The PPI network was visualized using Cytoscape version 3.7.

Results:
A total of 145 target genes of Pf3D7 were predicted, with the following genes repeatedly targeted: conserved Plasmodium proteins, conserved Plasmodium membrane proteins, PfEMP1, rifin, RAD54, E3 ubiquitin-protein ligase, and transcription factors related genes. Outputs of ShinyGO included enriched GO pathways of 62 uniquely identified Pf3D7 genes with detailed descriptions and visualized networks. For overlapping relationships, a hierarchical clustering tree of enriched gene sets was carried out, along with a genome plot for representing the chromosomal locations of these genes. According to their coding-noncoding distribution chart, most of these genes were found to be members of the coding gene family. Additionally, PPI-network analysis reported the top 10 hub nodes: PFE0400w, MAL13P1.380, MAL7P1.167, PFD0900w, PF11_0243, PFE0440w, PFE1120w, MAL13P1.315, PF08_0126, and MAL8P1.23. Three KEGG pathway diagrams of pfa 05144 for Malaria, pfa 03440 for homologous recombination, and pfa 00750 for vitamin B6 metabolism with identified Pf3D7 genes were drawn and high-lighted in red.

Conclusion:
The important target genes of Plasmodium falciparum 3D7 were identified by car-rying out a trans-kingdom investigation, thus offering preliminary insights into the potential of erythrocytic miRNAs-mediated trans-kingdom regulation.
Evaluation of the anticoccidial efficacy of quinfamide alone and in combination with carbopol in rabbits at weaning
Authors: Enríquez Ayari , Alcalá Yazmín , Sumano Héctor , Aquino Itzcoatl 
Published: February 2025

This study aimed to evaluate the anticoccidial activity of quinfamide in rabbits during the weaning period, which is considered a particularly vulnerable time for the clinical presentation of coccidiosis. Thirty-day-old New Zealand rabbits were included in this trial and were divided into the following groups: randomized control, non-randomized control, quinfamide (30 mg/kg) + carbopol; quinfamide (30 mg/kg); quinfamide (60 mg/kg) + carbopol and quinfamide (60 mg/kg). Treatments were administered orally by mixing the drugs with the rabbits’ standard feed. Weight, daily weight gain, feed intake, conversion, and oocyst shedding were recorded for 14 days. The groups treated with quinfamide and quinfamide (60 mg/kg) + carbopol showed a clear improvement in the evaluated parameters compared to the control groups, and there was an increase in the duration during which oocysts in feces could not be detected. The group treated with quinfamide (30 mg/kg) + carbopol also presented better results than the control groups. In contrast, the group treated with quinfamide (30 mg/kg) alone, did not show any differences compared to control groups. Based on these results, it can be considered that quinfamide may present a useful anticoccidial effect, similar to the one obtained with other anticoccidial drugs in rabbits, but only when pharmaceutically prepared with carbopol as quinfamide retentive polymer in the gastrointestinal tract.
Barnehageovertakelse – en svært realistisk praksis
Authors: Lysklett Olav B. , Berger Henrik Wien Berre 
Published: February 2025

Barnehagelærerutdanningen er en profesjonsutdanning der det legges stor vekt på praksis. Denne skal bidra til kontinuitet og progresjon i studiet, og til å skape sammenheng mellom teoretisk og praktisk kompetanse. Likevel mener nyutdannede barnehagelærere at gapet mellom utdanningen og barnehagehverdagen er stort. Siden 2005 har Dronning Mauds Minne høgskole gjennomført en ukes barnehageovertakelse i tillegg til ordinær praksis. Denne studien har som mål å finne ut hvordan studentene erfarer en slik barnehageovertakelse. 79 studenter deltok i en spørreundersøkelse etter gjennomført barnehageovertakelse. Studentene vurderer barnehageovertakelse som realistisk og lærerik. De opplever at de ansatte i barnehagen gir dem stor frihet, og at de får et stort ansvar. Samarbeidet studentene har med hverandre og med barnehagene, fremheves også. Barnehageovertakelse kan dermed bidra til å gjøre studentene bedre rustet som profesjonsutøvere i barnehagen. At de får bedre tid til å forberede overtakelsen, og at den kan gjennomføres i god tid før eksamen, blir av studentene fremhevet som mulige forbedringer. Mer tid til refleksjoner over læringsutbytter, og gjerne med en lærer som veileder, kan og gjøre barnehageovertakelsen mer lærerik.
ENGLISH ABSTRACT
Adoption of Early Childhood Education and Care Institutions – Authentic PracticeA profession is defined by the completion of specialized professional training, and in teacher training for Early Childhood Education and Care nstitutions (ECEC), there is a strong emphasis on practical experience. This practical training aims to foster continuity, coherence, and progression in the student’s journey towards becoming a proficient ECEC practitioner. However, newly qualified ECEC teachers often perceive a considerable gap between their formal education and the realities of daily life in ECEC settings. Since 2005, Queen Maud University College has implemented ECEC adoption, in addition to regular practical training. This study explores student’s experiences after one week of ECEC adoption. 79 students filled out a questionnaire. Students view ECEC adoption as an authentic and educational experience. Consequently, ECEC adoption plays a pivotal role in equipping students with the skills and knowledge required to excel as professionals in the ECEC sector. Students suggest a few potential improvements. These include allocating more time for preparations and ensuring that ECEC adoption does not coincide closely with exams. Additionally, dedicating more time for reflection on learning outcomes, under the guidance of supervision, could enhance the value of ECEC adoption.
Experience in the use of multimodal analgesia in victims of road accidents with combined chest and abdominal injuries in the prehospital and hospital periods
Authors: Miroshnichenko A. G. , Teplov V. M. , Rakhmanov R. M. , Bolshakova M. A. , Popov A. A. , Popova E. A. , Rakhmanova E. A. , Mamedov R. A. 
Published: February 2025

Objective. Тo evaluate the possibility of using analgesics, dalargin and correctors of tissue metabolism in multimodal analgesia in victims of road accidents with combined chest and abdominal trauma.Tasks: To study the combined effect of multimodal analgesia with the inclusion of dalargin, ketorolac or lornoxicam and a corrector of metabolic disorders on clinical and biochemical parameters, changes in gas composition, acid-base blood state and neuro-humoral condition in victims of road accidents with combined chest and abdominal trauma in the acute period of traumatic illness. 2. To propose standard schemes of multimodal anesthesia that can be applied to groups of victims with combined chest and abdominal trauma of varying severity during evacuation from the scene of a traffic accident by emergency medical personnel.Materials and methods. A study was conducted in 107 patients with diagnoses of road trauma, combined chest and abdominal trauma. In order to objectify the severity of the patients› condition, the Glasgow com, RAS scales and the method developed by us for assessing the severity of victims with combined trauma were used.The results of the study. Traumatic shock in victims of road accidents with combined chest and abdominal trauma leads to impaired consciousness, microcirculation, hypoxia, hypotension, while adaptation of the main body functions developed in an irrational way — due to tachycardia. This, in our opinion, is dangerous, as evidenced by the signs of ischemia on the ECG. The combined use of analgesics, dalargin and a tissue metabolism.Conclusion. The use of multimodal anesthesia in the prehospital period of emergency medical care made it possible to significantly reduce the patient›s hospital stay by 4.8 bed days and reduce the overall mortality rate in severely injured patients from 72.7% in the comparison group to 51.7% in the main group.
The Quasi-bound State as a Predictor of Relative Binding Free Energy
Authors: Serrano-Morrás Álvaro , Westermaier Yvonne , Majewski Maciej , Barril Xavier 
Published: February 2025

Relative binding free energy (ΔΔGbind) predictions have become the main approach to evaluate the potency of a congeneric series of compounds. They are enabled by alchemical transformations coupled to free energy methods, tools that have become essential in drug design. Yet, they are computationally expensive and are limited to small and relatively simple transformations. The ever-increasing size of virtual screening databases demands faster methods to assess virtual hits. Here, we show that the structural robustness of protein-ligand complexes, measured as the quasi-bound free energy (ΔGQB) by Dynamic Undocking (DUck), is well suited to detect outliers in the structure-activity continuum (i.e., activity cliffs), which are particularly challenging for knowledge-based approaches. On congeneric series of HSP90α, CDK2 and BACE-1 inhibitors, we demonstrate that ΔGQB can deliver excellent predictions, despite the local nature of the measurement, in some cases, comparable to the much more computationally demanding alchemical transformation methods. We find that for systems following a one-step dissociation model, ΔGQB actually informs about the free energy of the transition state, which allows us to predict relative binding kinetics and, when the series present relatively constant on-rates, also ΔΔGbind.This work has important implicatinos for drug discovery, as it shows that within a well-defined applicability domain, high-throughput computational dissociation studies can deliver ΔΔGbind predictions that compare well with rigorous alchemical transformation methods.
Esquema para el dimensionamiento de unidades de sedimentación de alta tasa de flujo ascendente
Authors: Rincón Alejandro , Herrera Oscar F. 
Published: February 2025

In this article a systematic methodological approach for the design of sedimentation units high rate upflow inclined plates is formulated. It uses the guidelines and the existing equations in the literature. The development raised to define appropriate values for surface charge (Cs) and ratio of plate length and distance between plates (l / d), which meet the guidelines for surface charge (Cs), retention time plates (tp), reason plate between length and distance between plates (l / d), and settlement critical speed (Vsc). The implementation of this methodology has benefits such as: i) indicate a clear order of the calculations that lead to meet the guidelines of the literature, without the need of trial and error, ii) indicate the permissible limits of user-defined variables. The example shows that the proposed plan may be simply carried to a computer, and the information generated by the computer allows for easy, quick and proper definition of the user-selected variables.
Diseño de un sistema de información para el análisis de indicadores de medición de la sociedad de la información
Authors: González-Zabala Mayda Patricia , Galvis-Lista Ernesto Amaru 
Published: February 2025

The purpose of this paper is to present the results of a research that was done in order to design an information system for the analysis of systems for measuring the information society. To achieve the results, the Design of Information Systems - DSI proposed from the Soft Systems Thinking was taken as research methodology. The Human Activity Systems were used for defining the activities to be supported, and an agile approach to software development, specifically; the method called extreme programming was used. The main results were: defining the indicators analysis process, a software tool that allows the recording of information relating to measure systems to be analyzed, and the analysis criteria, classification of variables and indicators and report generation and descriptive statistics of the variables and indicators analyzed.