bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combining antibiotic‐loaded bone cement‐based free vastus lateralis muscle‐sparing flap with split‐thickness skin grafts: A reliable strategy for reconstructing diabetic foot ulcers at non‐weight‐bearing areas
Authors: Chang Shusen , Jian Yang , Liu Chenxiaoxiao , Dal Prà Ilaria , Armato Ubaldo , Chen Xin , Zhou Jian , Chen Wei , Zhang Fang , Nie Kaiyu , De Santis Daniele , Deng Chengliang , Wei Zairong 
Published: May 2024

AbstractDiabetic foot ulcers (DFUs) present significant challenges due to their associated amputation rates, mortality, treatment complexity and excessive costs. Our earlier work introduced a wound surgical integrated treatment (WSIT) for DFUs, yielding promising outcomes. This study focuses on a specific WSIT protocol employing antibiotic‐loaded bone cement (ALBC) in the first Stage, and free vastus lateralis muscle‐sparing (VLMS) flaps and split‐thickness skin grafts (STSGs) in the second stage to repair non‐weight‐bearing DFUs. From July 2021 to July 2023, seven DFU patients (aged 47–71 years) underwent this treatment. Demographic data, hospital stay and repair surgery times were collected. Histological and immunohistochemical analyses assessed angiogenesis, collagen deposition and inflammation. SF‐36 questionnaire measured pre‐ and postoperative quality of life. Preoperative ultrasound Doppler showed that the peak blood flow velocity of the recipient area artery was significantly >30 cm/s (38.6 ± 6.8 cm/s) in all patients. Muscle flap sizes varied from 8 × 3.5 × 1 to 18 × 6 × 2 cm. The operation time of the repair surgery was 156.9 ± 15.08 minutes, and the hospital stay was 18.9 ± 3.3 days. Histological analysis proved that covering DFUs with ALBC induced membrane formation and increased collagen, neovascularization and M2 macrophages fraction while reducing M1 macrophages one. All grafts survived without amputation during a 7‐ to 24‐month follow‐up, during which SF‐36 scores significantly improved. A combination of ALBC with free VLMS flaps and STSGs proved to be safe and effective for reconstructing non‐weight‐bearing DFUs. It rapidly controlled infection, enhanced life quality and foot function, and reduced hospitalization time. We advocate integrating this strategy into DFU treatment plans.
A meta‐analysis of left ventricular dysfunction in ankylosing spondylitis
Authors: Bolaji Olayiwola , Oriaifo Osejie , Adabale Olanrewaju , Dilibe Arthur , Kuruvada Krishna , Ouedraogo Faizal , Ezeh Ebubechukwu , Nair Ambica , Olanipekun Titilope , Mazimba Sula , Alraies Chadi 
Published: May 2024

AbstractAnkylosing spondylitis (AS) is a chronic inflammatory arthritis affecting the spine, presenting a considerable morbidity risk. Although evidence consistently indicates an elevated risk of ischemic heart disease among AS patients, debates persist regarding the likelihood of these patients developing left ventricular dysfunction (LVD). Our investigation aimed to determine whether individuals with AS face a greater risk of LVD compared to the general population. To accomplish this, we identified studies exploring LVD in AS patients across five major databases and Google Scholar. Initially, 431 studies were identified, of which 30 met the inclusion criteria, collectively involving 2933 participants. Results show that AS patients had: (1) poorer Ejection Fraction (EF) [mean difference (MD): −0.92% (95% CI: −1.25 to −0.59)], (2) impaired Early (E) and Late (atrial—A) ventricular filling velocity (E/A) ratio [MD: −0.10 m/s (95% CI: −0.13 to −0.08)], (3) prolonged deceleration time (DT) [MD: 12.30 ms (95% CI: 9.23–15.36)] and, (4) a longer mean isovolumetric relaxation time (IVRT) [MD: 8.14 ms (95% CI: 6.58–9.70)] compared to controls. Though AS patients show increased risks of both systolic and diastolic LVD, we found no significant differences were observed in systolic blood pressure [MD: 0.32 mmHg (95% Confidence Interval (CI): −2.09 to 2.73)] or diastolic blood pressure [MD: 0.30 mmHg (95% CI: −0.40 to 1.01)] compared to the general population. This study reinforces AS patients' susceptibility to LVD without a notable difference in HTN risk.
Dynamic analyses of a soft tissue–implant interface: Biological responses to immediate versus delayed dental implants
Authors: Aellos Fabiana , Grauer Joseph A. , Harder Kasidy G. , Dworan Julia S. , Fabbri Giacomo , Cuevas Pedro L. , Yuan Xue , Liu Bo , Brunski John B. , Helms Jill A. 
Published: May 2024

AbstractAimTo qualitatively and quantitatively evaluate the formation and maturation of peri‐implant soft tissues around ‘immediate’ and ‘delayed’ implants.Materials and MethodsMiniaturized titanium implants were placed in either maxillary first molar (mxM1) fresh extraction sockets or healed mxM1 sites in mice. Peri‐implant soft tissues were evaluated at multiple timepoints to assess the molecular mechanisms of attachment and the efficacy of the soft tissue as a barrier. A healthy junctional epithelium (JE) served as positive control.ResultsNo differences were observed in the rate of soft‐tissue integration of immediate versus delayed implants; however, overall, mucosal integration took at least twice as long as osseointegration in this model. Qualitative assessment of Vimentin expression over the time course of soft‐tissue integration indicated an initially disorganized peri‐implant connective tissue envelope that gradually matured with time. Quantitative analyses showed significantly less total collagen in peri‐implant connective tissues compared to connective tissue around teeth around implants. Quantitative analyses also showed a gradual increase in expression of hemidesmosomal attachment proteins in the peri‐implant epithelium (PIE), which was accompanied by a significant inflammatory marker reduction.ConclusionsWithin the timeframe examined, quantitative analyses showed that connective tissue maturation never reached that observed around teeth. Hemidesmosomal attachment protein expression levels were also significantly reduced compared to those in an intact JE, although quantitative analyses indicated that macrophage density in the peri‐implant environment was reduced over time, suggesting an improvement in PIE barrier functions. Perhaps most unexpectedly, maturation of the peri‐implant soft tissues was a significantly slower process than osseointegration.
A BEST classification system of large to giant congenital melanocytic nevi based on expert consensus and distribution characteristics
Authors: Song Ge , Dai Tao , Chang Yajie , Pei Huile , Liu Wuping , Guo Pengfei , Ren Yongqiang , Shen Guiping , Feng Jianghua 
Published: May 2024

AbstractBackgroundLarge to giant congenital melanocytic nevi (LGCMN) significantly decrease patients' quality of life, but the inaccuracy of current classification system makes their clinical management challenging.ObjectivesTo improve and extend the existing LGCMN 6B/7B classification systems by developing a novel LGCMN classification system based on a new phenotypic approach to clinical tool development.MethodsThree hundred and sixty‐one LGCMN cases were categorized into four subtypes based on anatomic site: bonce (25.48%), extremity (17.73%), shawl (19.67%) and trunks (37.12%) LGCMN. A ‘BEST’ classification system of LGCMN was established and validated by a support vector machine classifier combined with the 7B system.ResultsThe most common LGCMN distributions were on bonce and trunks (bathing trunk), whereas breast/belly and body LGCMN were exceptionally rare. Sexual dimorphism characterized distribution, with females showing a wider range of lesions in the genital area. Nearly half of the patients with bathing trunk LGCMN exhibited a butterfly‐like distribution. Approximately half of the LGCMN with chest involvement did not have nipple–areola complex involvement. Abdomen, back and buttock involvement was associated with the presence of satellite nevi (r = 0.558), and back and buttock involvement was associated with the presence of nodules (r = 0.364).ConclusionsThe effective quantification of a standardized anatomical site provides data support for the accuracy of the 6B/7B classification systems. The simplified BEST classification system can help establish a LGCMN clinical database for exploration of LGCMN aetiology, disease management and prognosis prediction.
Drug utilization among young adults with atopic dermatitis: Influence of sex, socio‐economic status and disease severity
Authors: Carmanius P. L. , Lundin S. , Ödling M. , Kimland E. , Ballardini N. , Melén E. , Bergström A. , Dahlén E. 
Published: May 2024

AbstractBackgroundAtopic dermatitis (AD) affects individuals of all ages, and the first‐line treatment are emollients and topical corticosteroids. There is insufficient knowledge about factors possibly affecting the drug utilization of young adults with AD.ObjectivesTo describe the drug utilization of young adults with AD in relation to sex, socio‐economic status and disease severity.MethodsA cross‐sectional study based on the 24‐year follow‐up from the population‐based BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology Survey) birth cohort linked with dispensing data from the National Drug Register (n = 2912). Self‐reported AD and socio‐economic status were defined from questionnaire data and disease severity was determined through the clinical examination and Patient‐Oriented Eczema Measure questionnaire.ResultsThe prevalence of AD in young adults was 17.7% (n = 516) and 45.5% of them were dispensed at least one drug for the treatment of AD during the study period (January 2016 to June 2019). Topical corticosteroids (TCS) were the most common drugs (32.9%) followed by emollients (21.7%). A larger proportion of men were dispensed TCS than women (39.0% vs. 29.1%: p‐value = 0.020). A larger proportion of young adults with moderate‐to‐severe AD were dispensed TCS than those with mild AD (52.6% vs. 35.3%: p‐value = 0.026). No one was dispensed the recommended amount of emollients and less than five individuals were dispensed the recommended amount of TCS for mild disease. Male sex (adj.OR 1.54, 95% CI 1.06–2.34) and moderate‐to‐severe AD (adj.OR 2.62, 95% CI 1.59–4.31) were associated with dispensation of TCS.ConclusionsA large proportion of young adults with AD was undertreated or untreated. Sex and disease severity did affect the dispensing patterns of investigated drugs.
Lipids as biomarkers to assess the nutritional and physiological status of two diadromous fish (Anguilla anguilla and Chelon auratus) at early life stages in a temperate macrotidal estuary
Authors: Arevalo Elorri , Mazzella Nicolas , Cabral Henrique N. , Moreira Aurélie , Jan Gwilherm , Villeneuve Bertrand , Possémé Carl , Lepage Mario 
Published: May 2024

AbstractEstuaries are considered as key habitats for the early life stages of fish. However, in the face of massive destruction of many estuarine intertidal areas, management and conservation measures are needed. Fish condition indicators may be used as a proxy of habitat quality and provide valuable information for management of coastal areas. In this study, the larvae of golden mullet (Chelon auratus) and European glass eels (Anguilla anguilla) were sampled in three sites of the Gironde Estuary. Different lipid classes and fatty acids were quantified: phospholipids (globally, phosphatidylethanolamine and phosphatidylcholine), triglycerides, omega‐3 (particularly docosahexaenoic and eicosapentaenoic acids), omega‐6 and C18:1. These biomarkers provide information on the nutritional status of the larvae as well as on prey availability and larvae diet between sites. One site significantly differed from the others as it seemed to offer abundant and better‐quality prey. The very high levels of omega‐3 contained in mullet larvae suggested that this site provided a high amount of diatoms. However, the mullet larvae that colonized this site also showed physiological stress that could be explained by exposure to pollutants through their prey. This work constitutes an essential baseline for developing biomarkers to assess the quality of habitats in a global change context.
Randomized, crossover trial: comparing the effects of standardized egg‐white meal and Vital® on global gastric emptying parameters and intragastric meal distribution in healthy Asian participants
Authors: Tagiling Nashrulhaq , Ibrahim Izleen Laili , Lee Yeong Yeh , Udin Muhamad Yusri , Mohamad Kamarulzaman Mohamad Dzulhilmi , Phoa Picholas Kian Ann , Damulira Edrine , Mohd Rohani Mohd Fazrin , Wan Zainon Wan Mohd Nazlee , Mat Nawi Norazlina 
Published: May 2024

AbstractBackground and AimMeasurements of gastric emptying and accommodation for alternative test‐meal protocol during gastric emptying scintigraphy (GES), such as high‐calorie nutrient drinks, are not fully established. We aimed to compare the effects of standardized egg‐white meal (EWM) versus high‐calorie nutrient drink (Vital®; Abbott Laboratories) on global GES parameters and intragastric meal distribution at immediate scan (IMD0h).MethodsOf 84 screened participants, 60 asymptomatic healthy Asian population (38 females; 24.0 ± 1.5 years; 23.8 ± 2.6 kg/m2) were recruited in this 2 × 2 (AB/BA) crossover trial. Participants were randomized to a 4‐h GES with 99mTc‐radiolabeled EWM (~255.8 kcal), followed by a 200 mL Vital® (300 kcal), or vice versa, separated by a 2‐week washout period. Global meal retention (GMR), power‐exponential model emptying parameters (half‐emptying [T1/2], lag phases [Tlag2%, Tlag5%, Tlag10%]), and IMD0h were determined and compared.ResultsGMRs for both test meals were within the international standard references for solid GES. Compared to EWM, Vital® exhibited significantly lower GMRs (faster emptying) from 0.5 to 3 h (all P < 0.001) but comparable at 4 h (P = 0.153). Similar observations were found for the model‐based T1/2 and the different Tlag thresholds (all P < 0.001). Furthermore, IMD0h was found to be lower with Vital®, indicating lower gastric accommodation (faster antral filling) immediately post‐ingestion (P < 0.001). Both test meals showed significant moderate‐to‐strong positive associations at the late‐phase GE (GMR 2–4 h, T1/2) (all P < 0.05).ConclusionsOverall, Vital® is an acceptable alternative test meal to the EWM for GES; however, exercise caution when interpreting early‐phase GE. The normative values for global GES parameters and IMD0h are also established.
Genetic and clinical profile of 15 Chinese families with GDAP1‐related Charcot–Marie–Tooth disease and identification of H256R as a frequent mutation
Authors: Li Zhongzheng , Zeng Sen , Xie Yongzhi , Li Xiaobo , Huang Shunxiang , Zhao Huadong , Cao Wanqian , Liu Lei , Wang Mengli , Gong Qiaoyu , Liu Jun , Rong Pengfei , Zhang Ruxu 
Published: May 2024

AbstractBackground and AimsMutations in ganglioside‐induced differentiation‐associated protein 1 (GDAP1) cause axonal or demyelinating Charcot–Marie–Tooth disease (CMT) with autosomal dominant or recessive inheritance. In this study, we aim to report the genotypic and phenotypic features of GDAP1‐related CMT in a Chinese cohort.MethodsClinical, neurophysiological, genetic data, and available muscle/brain imaging information of 28 CMT patients with GDAP1 variants were retrospectively collected.ResultsWe identified 16 GDAP1 pathogenic variants, among which two novel variants c.980dup(p.L328FfsX25) and c.480+4T>G were first reported. Most patients (16/28) presented with AR or AD CMT2K phenotype. Clinical characteristics in our cohort demonstrated that the AR patients presented earlier onset, more severe phenotype compared with the AD patients. Considerable intra‐familial phenotypic variability was observed among three AD families. Muscle atrophy and fatty infiltration in the lower extremity were detected by Muscle magnetic resonance imaging (MRI) scans in four patients. MRI showed two AR patients showed more severe muscle involvement of the posterior compartment than those of the anterolateral compartment in the calf. One patient carrying Q38*/H256R variants accompanied with mild periventricular leukoaraiosis.ConclusionsIn this study, we conducted an analysis of clinical features of the GDAP1‐related CMT patients, expanded the mutation spectrum in GDAP1 by reporting two novel variants, and presented the prevalent occurrence of the H256R mutation in China. The screening of GDAP1 should be particularly emphasized in Chinese patients with CMT2, given the incomplete penetrance and pathogenic inheritance patterns involving dominant and recessive modes.
Critical care nurses' role in rapid response teams: A qualitative systematic review
Authors: Holtsmark Christina , Larsen Marie Hamilton , Steindal Simen A. , Solberg Marianne Trygg 
Published: May 2024

AbstractAimTo analyse the qualitative evidence on the role of critical care nurses in rapid response teams.DesignQualitative systematic review.MethodsThis qualitative systematic review employed Bettany‐Saltikov and McSherry’s guidelines and is reported according to the Enhancing Transparency in Reporting the Synthesis of Qualitative Research checklist. Two pairs of blinded researchers screened the articles. The data were synthesised using a thematic analysis approach.Data SourcesA systematic literature search was conducted using the CINAHL, Embase and MEDLINE databases.ResultsSeven studies were included, and three main roles were identified: (1) balancing between confidence and fear in clinical encounters, (2) facilitating collaboration and (3) managing challenging power dynamics in decision‐making.ConclusionCritical care nurses possess extensive knowledge and skills in providing critical care to patients experiencing deterioration on general wards. They play a vital role in facilitating collaboration between team members and ward staff. Furthermore, within the rapid response team, critical care nurses assume leadership responsibilities by overseeing the comprehensive coordination of patient care and actively engaging in the decision‐making process concerning patient care.Implications for the ProfessionHighlighting the central role of critical care nurses in rapid response teams as well such a team’s benefits in healthcare organisations can promote applications for funding to support further quality assurance of rapid response teams and thus enhance patient safety.ImpactHealth care organisations can assure the quality of rapid response team by providing economical resources and training. The education providers should facilitate and standardise curriculum for critical care nursing students to achieve necessary knowledge and skills as members in rapid response teams.Patient or Public ContributionNo patient or public contribution.
Disentangling between‐ and within‐person variation in relationship science
Authors: Mund Marcus , Park Yoobin , Nestler Steffen 
Published: May 2024

AbstractObjectiveThis article provides an overview of the Cross‐Lagged Panel Model (CLPM), Random‐Intercept Cross‐Lagged Panel Model (RI‐CLPM), and Latent Curve Model with Structured Residuals (LCM‐SR), highlighting the major issues of the CLPM for relationship science, and discusses dyadic extensions of those three models.BackgroundUnderstanding interdependencies among people and constructs is a central interest in relationship science. Addressing such research questions requires complex designs ideally using data collected at multiple measurement occasions of multiple constructs from at least two persons (e.g., both partners of a couple). The Cross‐Lagged Panel Model (CLPM) has been widely used to analyze such data, however, particularly during the last decade, it has been pointed out that the CLPM confounds between‐ and within‐person variation. As a consequence, alternative models such as the Random‐Intercept Cross‐Lagged Panel Model (RI‐CLPM) and the Latent Curve Model with Structured Residuals (LCM‐SR) were proposed that aim to disentangle between‐ and within‐person variation and, hence, allow conclusions regarding within‐person dynamics.MethodAs an illustrative example, we apply dyadic extensions of the CLPM, RI‐CLPM, and LCM‐SR to investigate the dynamic interplay between depression and relationship satisfaction in a sample of 1699 mixed‐gender couples surveyed in the German Family Panel.ResultsWhile the CLPM indicated a reciprocal relationship between depression and satisfaction, the RI‐CLPM and LCM‐SR indicated a unidirectional association flowing from depression to satisfaction.ConclusionWe discuss how findings like this can foster theory‐building and, ultimately, strengthen relationship science.
Can We Explain the Generation Gap in Churchgoing?
Authors: Stolz* Jörg , Lipps Oliver , Voas David , Antonietti Jean‐Philippe 
Published: May 2024

AbstractIn western societies, secularization in the sense of declining individual religiosity is mainly caused by cohort replacement. Every cohort is somewhat less religious than its predecessor, indicating that religious transmission is incomplete. The puzzle is just what causes this incomplete transmission and whether there is one or a restricted number of factors that mainly explain the process. Our aim in this article is to establish, describe, and explain this lack of religious transmission in West Germany, comparing parents’ and children's level of church attendance and their determinants over time. We use a data set of more than 8,000 parent‐child pairs across four cohorts from the German Socio‐Economic Panel (SOEP) and test whether indicators measuring parent attributes, family relations, or parental context influence the attendance gap. As expected, we find a substantial parent‐child attendance gap. However, we do not find factors that mainly explain the process. Only family disruption and the percentage of nones in the state slightly increase the attendance gap, but effect sizes are small. Our surprising result is that secularization happens largely independently of attributes of the parents and their immediate surroundings. We discuss how this finding may give credibility to new theories of secular transition and present an agenda for future research on religious transmission.
Ten Years After: Revisiting the Ouster Of Egypt's Muslim Brotherhood
Authors: Hussein Ebtisam 
Published: May 2024

AbstractThe ouster of President Hosni Mubarak in 2011 marked a turning point in Egypt's modern history. The long‐persecuted Muslim Brotherhood immediately became a key political player, and its candidate, Mohamed Morsi, won election to lead the country. But despite those two years of popular engagement and victories at the ballot box, Morsi was ousted and the movement banished once again after a confrontation with the military in July 2013. Why did the Brotherhood choose to risk a conflict with the armed forces and not seek a compromise? This article contends that the decision was driven by the Muslim Brotherhood's long history of persecution, its broad base of support, its impressive successes after Mubarak fell, and its fear of losing the presidency. These set the Brotherhood on a course of action that suited its experiences and preferences. This path led the movement to ignore several facts suggesting it must seek to coordinate with the armed forces: The Brotherhood and the military did not enjoy cordial relations after Morsi's election in 2012; the movement's grassroots power was substantial, but there was no evidence it could prevail over the military's demand for Morsi to step down; and the military maintained its internal cohesion. Therefore, the Muslim Brotherhood's historical path guided its decision to avoid cooperation.
Diffuse infiltrating tumour with the molecular profile of an atypical teratoid rhabdoid tumour (AT/RT SHH‐1B) in an adult patient
Authors: Cordier Fleur , Schouten Joost W. , Geurts Marjolein , Kros Johan M. , Dubbink Hendrikus J. , Verlinden Vincent , Federico Aniello , Kool Marcel , Maas Sybren L. N. 
Published: May 2024

AbstractWe describe a 46‐year‐old patient with an IDH‐wildtype diffusely infiltrating atypical teratoid/rhabdoid tumour (AT/RT), SHH‐1B molecular subtype. The unusual histology and subsequent diagnosis in an adult patient will be discussed.