bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choroidal neovascularization associated with adult‐onset vitelliform dystrophy treated with intravitreal ranibizumab
Authors: PRIETO CALVO E , EGEA ESTOPINAN C , GUERRI MONCLUS N , TORRÓN FERNÁNDEZ‐BLANCO C , IDOIPE CORTA M 
Published: November 2010

Abstract Purpose Adult‐onset foveomacular dystrophy (AFVD) is a hereditary ocular condition, which results in the presence of slightly elevated and yellowish subretinal macular lesions, similar to those of Best’s disease, but smaller than these. Usually, these patients have a fair visual prognosis if there are no complications in the clinical course of the disease. We report a case describing a patient affected with occult choroidal neovascularization (CNV) associated with AFVD, who underwent treatment with intravitreal ranibizumab. Methods Prospective, interventional, single case report. A 70‐year‐old male patient diagnosed with bilateral adult‐onset vitelliform dystrophy, presents a sudden decrease of vision in his left eye (LE) associated with a subretinal haemorrhage and serous detachment in the macular area, on fundus examination. Fluorescein angiography in the LE confirmed the presence of an occult choroidal neovascular membrane. Intravitreal ranibizumab was performed because of the juxtafoveal localization of the CNV. Results Two consecutive injections were needed to induce total regression of the lesion. Six months after the last injection, visual acuity remained stable at 7/10 with no recurrence as evaluated by fundus biomicroscopy and optical coherence tomography (OCT). Conclusion Intravitreal ranibizumab has shown a satisfactory morphological and functional improvement in this case of CNV associated with adult‐onset vitelliform dystrophy. Further case series are required to confirm this observation.
Influence of age on visual results of intravitreal bevacizumab for myopic choroidal neovascularization
Authors: KORT F , CHEBIL A , BOULADI M , BOURAOUI R , BEN YOUSSEF N , MERDASSI A , EL MATRI L 
Published: November 2010

Abstract Purpose To evaluate the influence of age on the visual and anatomic outcome of myopic patients with choroidal neovascularization (CNV) treated with intravitreal bevacizumab (IVB). Methods Review of retrospectively collected data of 52 eyes in 50 patients with myopic CNV treated with IVB injections (1.25 mg/ 0.05ml). According to the age at onset of CNV, patients were divided into 2 groups: A younger group (< 50 years); (n=25, 27 eyes) and an older group (≥ 50 years); (n=25, 25 eyes). Best corrected visual acuity (BCVA) and central retinal thickness (CRT) measured with optical coherence tomography (OCT) were compared between the two groups over 12 months. Results The mean number of IVB injections was 1.8 in the younger group and 2.0 in the older group. In the younger group, mean BCVA improved from 1.32 logMAR at baseline to 0.77 logMAR at 12 months (p=.002). In the older group, BCVA improved from 1.0 logMAR to 0.84 logMAR at 12 moths (p=.035). There was a mean of 5.1 lines improvement in BCVA from baseline in the younger group versus a mean of 2.2 lines improvement in the older group (p<.05). Decrease in mean CRT was significantly higher in the younger group than in the older one at 12 months: 114.02µm and 68.8µm respectively (p=.003). Conclusion Visual prognosis of myopic CNV treated with IVB seems to be better in patients younger than 50 years.
Spontaneous peeling of idiopathic epiretinal membranes: a case series
Authors: LOH BK , LEE SY , YEO I , ANG CL , WONG D 
Published: November 2010

Abstract Purpose To report clinical presentations and optical coherence tomographic features of spontaneous peeling of idiopathic epiretinal membranes in two young myopic females Methods Retrospective review of cases including clinical presentations and optical coherence tomography (OCT) scans Results Spontaneous peeling of idiopathic epiretinal membranes occurred in two young myopic females. The peeling occurred with posterior vitreous detachments which were documented sequentially with OCT over a 3 to 6 months duration. Case 1, a 31‐year‐old lady, with myopia of ‐6.0 dioptres spherical equivalent(SE), presented with decreased left visual acuity for one week. Left best corrected visual acuity (BCVA) was 6/12. Fundus examination revealed ERM confirmed by OCT. One month later BCVA improved to 6/9 as the ERM spontaneously peeled off partially with presence of PVD. However OCT still demonstrated vitreofoveal traction. BCVA normalized to 6/6 with complete peeling of ERM, resolution of vitreofoveal traction at both months 2 and 6. Case 2, a 35‐year‐old lady, with myopia of ‐2.0 dioptres SE, experienced 2 week history of decreased left visual acuity to BCVA 6/9 from ERM. 3 months later, spontaneous peeling of ERM occurred simultaneously with PVD. BCVA improved to 6/6 which remained stable one year later. Conclusion Spontaneous peeling of idiopathic ERM can occur in young female myopes. Two cases developed early PVD with spontaneous ERM peeling. OCT confirms the simultaneous occurrence of PVD with peeling of membranes which has not been demonstrated before. Idiopathic ERM should be monitored closely in myopic eyes of young females as they may undergo spontaneous peeling with normalisation of visual acuity.
Macular thickness measurements in epiretinal membrane using Fourier domain optical coherence tomography devices
Authors: GARCIA MARTIN E , PINILLA I , IDOIPE M , CRUZ N , FUERTES MI , ABECIA E , CALVO P , PRIETO E , GUERRI MONCLUS N 
Published: November 2010

Abstract Purpose To compare new Fourier‐domain optical coherence tomographies (OCT) for measuring retinal thickness in eyes with idiopatic epiretinal membrane (EM). Methods Forty eyes diagnosed of EM of 40 patients (24 men and 16 women, aged 37 to 81 years) without other ophthalmic diseases, were prospective and consecutively studied. All of them underwent a ophthalmic examination including best corrected visual acuity, fundus examination, three Cirrus HD‐OCT (Carl Zeiss Meditec, Inc., Ca, USA) and three Spectralis OCT (Heidelberg Engineering, Germany). Comparisons of OCT measurements were done for the nine macular areas defined by the Early Treatment Diabetic Retinopathy Study (ETDRS). Correlations between OCT measures were studied by Pearson test. Results Mean total retinal thicknesses were 425.36 ± 88.62 μm using Cirrus HD and 440.75 ± 97.02 μm with Spectralis OCT. All retinal measurements showed significant differences between the two devices (p<0.05), except in inferior inner ETDRS area. The mean value for retinal thickness measurements was 15.39 µm less using Cirrus HD‐OCT. Cirrus and Spectralis OCT parameters showed good correlations. Conclusion Epirretinal membrane eyes evaluated by Cirrus and Spectralis OCT show differences in their macular measurements.
Macular thickness measurements in macular hole using Fourier domain optical coherence tomography devices
Authors: PINILLA I , GARCIA‐MARTIN E , IDOIPE M , FUERTES I , CRUZ N , ABECIA E 
Published: November 2010

Abstract Purpose To compare new Fourier‐domain optical coherence tomographies (OCT) for measuring retinal thickness in eyes with macular hole (MH). Methods Thirty‐eight eyes from 38 patients diagnosed of MH (17 men and 21 women, aged 51‐ 82 years) without other ophthalmic diseases, were prospective and consecutively studied. All of them underwent a ophthalmic examination including best corrected visual acuity, fundus examination, three Cirrus HD‐OCT (Carl Zeiss Meditec, Inc., Ca, USA) and three Spectralis OCT (Heidelberg Engineering, Germany). Comparisons of OCT measurements were done for the nine macular areas defined by the Early Treatment Diabetic Retinopathy Study (ETDRS). Correlations between OCT measures were studied by Pearson test. Results Mean total retinal thicknesses were 347.0 ± 67.78 μm using Cirrus HD and 344.71 ± 43.63 μm with Spectralis OCT. All retinal measurements showed significant differences between the two devices (p<0.05), except in superior and nasal inner ETDRS area. The mean value for retinal thickness measurements was 21.44 µm less using Cirrus HD‐OCT. Cirrus and Spectralis OCT parameters showed good correlations. Conclusion MH eyes evaluated by Cirrus and Spectralis OCT show differences in their macular measurements.
Prospective study of anatomical and functional outcome after surgery of phakic and pseudophakic rhegmatogenous retinal detachments in high myopia
Authors: BERNHEIM DB 
Published: November 2010

Abstract Purpose To compare anatomic and functional results of primary rhegmatogenous retinal detachment (RD) in high myopic eyes according to the lens status Methods From the database of 835 patients prospectively studied, 191 patients with high myopia were included (151 phakic and 40 pseudophakic eyes) and assessed for a minimal 6 months follow‐up examination in this multicentric study. Each patient underwent a detailed preoperative evaluation including symptom duration, best corrected visual acuity (logMAR), intraocular pressure, lens status, fundus examination, and axial length. Surgery (pars plana vitrectomy (PPV) or scleral buckling) was left to the surgeon choice. Baseline and follow‐up data were recorded at presentation, 1 and 6 months or more. The main endpoints were the primary reattachment rate at the 6‐month visit; the final anatomical success rate, the postoperative VA (>20/40) and intra‐ and postoperative complications. Results The analysis showed 96% primary reattachment, and 54% (single surgery) or 44% (multi‐surgery) visual acuity equal to or better than (≥20/40). Pseudophakic eyes differed from phakic eyes by age (older: 60.810.4 vs 49.912.3, p<0.001), smaller pupil dilation (8.01.5 mm vs 8.51.2 mm, p=0.02), more frequent PPV (80% vs 28.5%, p<0.001) and an higher rate of primary reattachment (92.5% vs 80.7%, p=0.05). Conclusion This prospective study showed similar baseline RD characteristics for high myopic phakic or pseudophakic eyes, and a primary reattachment rate higher for pseudophakic eyes. After single or multi‐surgery the functional prognosis was the same in the two groups and close to the published results in emmetropic eyes. Despite its anatomic particularities and morbidity risk
Paediatric retinal detachments: clinical characteristics and surgical outcomes
Authors: TAN GS , LEE SY , WONG E 
Published: November 2010

Abstract Purpose To evaluate the clinical characteristics and surgical outcomes of paediatric retinal detachment in an Asian population. Methods A retrospective case series of all patients aged 18 years and under who underwent retinal detachment surgery at the Singapore National Eye Centre from 1994 to 2008. Results 133 eyes in 116 patients were treated for retinal detachment over 15 years. 88 patients (75.9%) were male. The mean age was 14.0 years (range 3 to 18 years; median 15 years). Retinal detachment was caused by trauma in 13.5% (18 eyes). Myopia was the most common risk factor, present in 57 eyes (42.9%). 9% (12 eyes) had pseudophakic retinal detachment and 3.0% (4 eyes) had aphakic retinal detachment. The mean duration from onset of symptoms to presentation was 43 days (+/‐92.4). Initial visual acuity (VA) was 6/12 or better in 19.5% of eyes, while 53.9% of eyes had VA worse than 6/60 at presentation. The macula was still attached in only 22.1% of eyes. 85% of eyes had one retinal detachment surgery performed. 74% of our patients were treated with a sclera buckling procedure at the first instance. 18.3% had a combined vitrectomy with sclera buckling. Only 7.6% had primary vitrectomy as the initial treatment. 85% (113) of eyes achieved anatomical success defined by a completely attached retina on last followup, at least 6 months after last surgical procedure. 43.7% of eyes achieved a final postoperative VA of 6/12 or better. 76.2% of eyes had VA 6/60 or better. Conclusion Paediatric retinal detachments are characterised by delayed diagnosis, high incidence of macular involvement on presentation and a male predominance. In our series, myopia was the most common risk factor, which is not unexpected given the high incidence of childhood myopia in our population.
The role of nd:yag laser anterior hyaloidotomy to treat an entrapment of intravitreal triamcinolone in the beger´s space
Authors: ASCASO FJ , RUIZ DE GOPEGUI E , CASCANTE JM , DEL BUEY MA , CRISTOBAL BESCOS JA 
Published: November 2010

Abstract Purpose To describe a persistent entrapment of triamcinolone acetonide behind the crystalline lens (Berger´s space), a rare complication of intravitreal triamcinolone acetonide (IVTA) injection, and its successful drainage using a Nd:YAG laser anterior hyaloidotomy. Methods A case report providing a new indication of Nd:YAG laser, performing an anterior hyaloidotomy to release triamcinolone acetonide entrapped between the crystalline lens and the anterior hyaloids membrane following an IVTA injection. Results A 66‐year‐old male suffering from diffuse diabetic macular edema in his left eye was treated with an IVTA injection. The following day he complained from sudden loss of vision. Visual acuity dropped from 20/80 to "hand motion", and biomicroscopy showed a drug entrapment in the Berger´space. After a couple of weeks of observation treatment, Nd:YAG laser anterior hyaloidotomy was performed. One week later, slit lamp examination of the retrolental space revealed the complete disappearance of triamcinolone, visual acuity recovered to 20/50, remaining the means transparent. Conclusion We describe a minimally invasive, quick, simple and effective outpatient procedure to release rests of triamcinolone acetonide entrapped behind the crystalline lens. This indication of Nd:YAG laser has never been described before.
rtPA with SF6 gas usage in traumatic macular subretinal hemorrhage: a case report
Authors: MIGDAL E , HELEMEJKO I , MISIUK‐HOJLO M 
Published: November 2010

Abstract Purpose The eyeball blunt trauma, because of its specificity, may cause damage to the eye with various aspects. Retinal hemorrhages in the area of central vision, and thus in the macula area, threaten with irretrievable loss of vision. At the moment there is no precise standard of conduct prescribed for subretinal hemorrhage of various etiology and duration. In the Department of Ophthalmology at the Medical University in Wroclaw, in case of a subretinal hemorrhage not cutting across the vascular arches, the procedure is an intravitreal injection of recombinant tissue plasminogen activator (rtPA) with SF6 gas. Methods We report the case of a 39‐year‐old patient who came to the Department of Ophthalmology during emergency service due to blunt trauma of the left eye. Results rtPA with SF6 gas appears to be one of the best treatment strategy in macular subretinal hemorrhages caused by eyeball blunt trauma Conclusion The aim of this study is to show the rapid improvement of the vision after intravitreal injection of rtPA and gas SF6 in the described patient.
Pathophysiology of persistent submacular fluid after surgery for macula‐involving rhegmatogenous retinal detachment: hypothesis and review
Authors: VAN AKEN E , DERYCKE L , CORNELISSEN M , VECKENEER M 
Published: November 2010

Abstract Purpose To unravel the physiopathology of persistent submacular fluid (PSF) after successful primary rhegmatogenous retinal detachment (RD) repair for macula‐involving RD. To propose therapeutical and preventive measures for this phenomenon. Methods 9 eyes from 9 patients with macula‐involving RD underwent RD repair: 6/9 eyes got buckle surgery and 3/9 eyes got 20 gauge pars plana vitrectomy. The cellular content of subretinal fluid was studied by electron microscopy and anti‐Rhodopsin immunostaining. All eyes were followed further postoperatively for 12 months by spectral domain optical coherence tomography (SD‐OCT) for detection of PSF. Results Three out of nine samples were cell rich with cell counts of 7304/mm2, 20 270/mm2 and 9092/mm2 on cytospin. Six out of nine samples contained less than 1500 cells/mm2 and were scored as scantily cellular. The cells in the samples were predominantly rhodopsin immunopositive and showed structural features of photoreceptors or photoreceptor fragments on electron microscopy. Postoperative SD‐OCT scans demonstrating PSF in 3 eyes corresponded to the 3 cell rich peroperative subretinal samples. Conclusion Subretinal fluid obtained from patients with PSF is cell rich and contains predominantly photoreceptors and photoreceptor fragments. We speculate that a peroperative subretinal lavage might prevent postoperative PSF.
Coats disease: clinical findings and prognosis
Authors: DE FRANCESCO S , DE LUCA M , PIOZZI E , HADJISTILIANOU T 
Published: November 2010

Abstract Purpose To review the clinical variations and natural course of Coats disease. Methods We reviewed our experience with clinical features, staging and progression of the disease. In 37 consecutive patients, Coats disease was diagnosed in 15 under the age of 4y and in 22 over the age of 4y. All 37 patients had unilateral disease. The referral diagnoses were Coats disease and retinoblastoma. Patients in both groups (<4y and >4y) were classified into Stages 1 to 5. Results 15 out of 37 patients were diagnosed under the age of 4y (mean age 2.1y) and were Stage 4 and 5 at diagnosis. In the older group (>4y – mean age 7.1y) most cases were Stage 2 and 3; only one case was Stage 4. Most cases of the first group (<4y) presented a rapid progression of the disease, while older children with earlier stages have been successfully treated. Conclusion Coats disease is much more aggressive in very young children (<4y). Children diagnosed at an early age present a rapid progression to total exudative detachment, secondary glaucoma and phthisis. One of these cases presented Stage 5 disease at diagnosis with cholesterolosis of the anterior chamber. Older Children present a rather slow progression, a better response to treatment and a better visual prognosis.
Changes in visual acuity after intravitreal ranibizumab injections in patients with ischemic and non‐ischemic central retinal vein occlusion
Authors: MOUSTAKA L , AMARIOTAKIS G , PARIKAKIS E , KARAGIANNIS D , STRATOS A , BARLA P , MITROPOULOS P 
Published: November 2010

Abstract Purpose To evaluate changes in visual acuity after intravitreal injection of ranibizumab (0.5 mg) in patients with ischemic and non‐ischemic central retinal vein occlusion (CRVO). Methods In a retrospective study, 25 consecutive patients (25 eyes) where included, 15 eyes with ischemic CRVO and 10 eyes with non‐ischemic CRVO. Ophthalmic examination included decimal best corrected visual acuity (BCVA) and OCT at presentation and follow‐up visits. Changes on BCVA after treatment, in a period of follow up from 3 to 24 months, were evaluated. SPSS18 was used for statistical analysis. Results In ischemic CRVO group, patients’ mean age was 70.53 years. BCVA at presentation was 0.025 +/‐ 0.034 (mean +/‐SD), and BCVA at the last follow up was 0.072 +/‐ 0.13. The number of intravitreal injections performed was 3.07 +/‐ 2.12. In non‐ischemic CRVO group patients΄mean age was 69.60 years. BCVA at presentation was 0.33 +/‐ 0.22, and BCVA at the last follow up was 0.60 +/‐ 0.24. The number of intravitreal injections performed was 2.7+/‐ 1.2. In ischemic CRVO group there was no statistically significant improvement in visual acuity (0.046 +/‐ 0.13, paired t‐test p=0,186), whereas in non‐ischemic CRVO group the BCVA after treatment improved significantly (0.27 +/‐ 0.23 paired t‐test p=0,006). Conclusion Intravitreal ranibizumab injections in patients with CRVO may result in a significant improvement of BCVA in patients with non‐ischemic CRVO. Future prospective studies and a larger number of patients are needed to verify these results.
Angioid streaks beyond pseudoxanthoma elasticum
Authors: DE ZAEYTIJD J , VANAKKER OM , COUCKE PJ , DE PAEPE A , LEROY BP 
Published: November 2010

Abstract Purpose Angioid streaks (AS) are funduscopic findings, caused by crack‐like dehiscences in elastic portions of Bruch membrane. AS are a manifestation of underlying systemic conditions, such as pseudoxanthoma elasticum (PXE), Paget disease, sickle cell anemia, other blood dyscrasias and, rarely, Ehlers‐Danlos syndrome. By far the commonest association is PXE. Differences and similarities of AS in β‐thalassemia minor, PXE‐like syndrome and Savanna haemoglobinopathy with AS seen in PXE are discussed. The description of AS in Savanna haemoglobinopathy is a first. Methods Angioid streaks were detected in one patient with β‐thalassemia minor, one with PXE‐like syndrome and one with Savanna haemoglobinopathy. They underwent a full ophthalmic work‐up. Molecular analysis of the ABCC6 gene to exclude PXE was performed by dHPLC (denaturing high‐performance liquid chromatography) and direct sequencing. Results A 34 year old lady with β‐thalassemia minor had a fundus appearance which was an exact phenocopy of PXE retinopathy, including angioid streaks, peau d’orange and comets. In contrast, a 51 year old lady with PXE‐like syndrome and a 55 year old man with Savanna haemoglobinopathy had a limited number of short, thick, feathered, white streaks around the optic disc. Conclusion AS differ in aspect depending on the underlying condition. The exact etiology of AS in these systemic conditions has not yet been elucidated. However, it is tempting to suggest that distinct pathogenetic mechanisms underlying very different blood dyscrasias as well as PXE, meet at a final common pathway, leading to breaks in Bruch membrane.
AMD edemas: diagnosis, follow‐up, therapeutic, prognosis, spectral domain OCT, fluorescein, ICG angiographies interests
Authors: GONZALEZ C 
Published: November 2010

Abstract Purpose To evaluate OCT, Fluorescein, ICG Angiography signs of various types edemas complicating AMD, so their diagnosis, follow‐up, therapeutic , prognosis value Methods 236 eyes of 203 patients, with retrofoveolar neovascularisation complicating AMD, were treated with a series of 3 IVT Ranibizumab protocol. First and 2 months’ interval follow‐up exam included ETDRS visual acuity (VA), complete ophthalmic examination, fluorescein(FA) and infracyanine (ICG) angiography, and Spectral Domain optical coherence tomography OCT ( Spectralis and Cirrus). Exudative and inflammatory reaction were analyzed cut to cut, cut by cut and time to time at OCT. Thickness, edema type, other lesions are always evaluated and compared. Results Diffuse edema was present in 90% eyes, focal diffuse in 25%, OMC in 60% cases , SRD in 30% , resorption vacuoles in 25% , inflammatory reaction in 95% cases, epiretinal membrane (ERM) was associated in 20% cases. During therapeutic protocol , diffuse edema was 70% reduced in 80%, OMC 75% in 65% cases, and SRD about 80% in 78% cases. OCT alone allow treatment decision in 74% cases, therapeutic protocol determination in 58% cases, prognosis and scalable potential pathology in 45% cases. FA, above all ICG were needed and necessary to determine neovascular activity. Conclusion Edemas are main signs of neovascular AMD. OCT is the reference exam for their evaluation. OCT efficiency and reliability depend on results’ analytic and comparative analysis. Confrontation of clinic, AF, ICG, OCT data enable diagnosis error coefficient to be down by 42% and prove anyone exam complement each other, particularly FA and ICG.OCT is of course necessary but not sufficient to well determine and evaluate AMD edemas.