bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mauerwerksbauten des Wohnungsbaus unter Erdbebeneinwirkung
Authors: Jäger Wolfram , Nguyen Song Ha , Schöps Peter 
Published: April 2010

AbstractEs werden die Ergebnisse eines Forschungsvorhabens vorgestellt, das vom Bundesamt für Bauwesen und Raumordnung gefördert worden ist und an ein vorheriges zu Mauerwerksbauten in Erdbebenzone 1 anschließt [1]. Mit Hilfe eines angepassten Materialgesetzes sind für standardmäßige Mauerwerksbauten des Wohnungsbaus die erforderlichen Schubwandquerschnitte gemäß DIN 4149 nachgerechnet worden. Die dort enthaltene Tabelle hat den Vorteil, dass auf einen Nachweis verzichtet werden kann, wenn die angegebenen Mindestquerschnittsflächen eingehalten sind. Diese konnten i.W. bestätigt bzw. in vielen Fällen sogar noch verringert werden, wenn man für die jeweiligen Stein‐Mörtel‐Kombinationen die entsprechenden Materialkennwerte ansetzt.Masonry structures in housebuilding under earthquake actions. Definition of structural provisions for abdication of calculational verification in the earthquake zones 2 and 3. Results of a research project funded by the Federal Office for Building and Regional Planning will be presented. It affiliates to a previous one on masonry structures in earthquake zone 1 [1]. The necessary crosssection areas according to DIN 4149 were recalculated for standard masonry structures for housebuilding. The there contained table has the advantage, that a calculational verification should not be done if the cross sectional area of the stiffening walls comply with the given minimum values. These values could be approved in generally and accordingly reduced in most cases, if the adequate material data were used for the respectively unitmortar‐combination.
Malignant solitary fibrous tumors in a renal allograft: The nephron‐sparing surgery option
Authors: Casaccia Marco , Fontana Iris , Nardi Ilaria , Bertocchi Massimo , Ghinolfi Davide , Sturdevant Mark , Gentile Raffaella , Valente Umberto 
Published: April 2010

AbstractMalignant solitary fibrous tumors (SFT) of the kidney are an unusual entity. In a search of the medical literature, this tumor has never been described in a renal allograft. We report a case of a 70‐year‐old female who developed a bifocal malignant SFT in a renal allograft 12 years after transplantation. The patient underwent enucleation of both lesions. Microscopic evaluation showed neoplastic proliferation of spindle‐shaped cells showing moderate atypia and frequent mitotic figures.At 12‐month follow‐up, the patient was tumor‐free and had preserved renal allograft function. Although transplant nephrectomy might be the conventional treatment for this pathology, a nephron‐sparing surgical approach allowed for the removal of both tumors while preserving allograft function. In this case, an informed patient dictated a treatment modality that would best maintain her high quality of life coupled with a reasonable expectation of a cure.
The dilemma of undocumented immigrants with ESRD
Authors: Rodriguez Rudolph A. 
Published: April 2010

AbstractThe National Kidney Foundation (NKF) 2010 Spring Clinical Meetings will take place April 13‐17 at the Walt Disney World Swan and Dolphin Hotel in Orlando, Fla. These multi‐disciplinary meetings will present opportunities for renal healthcare providers to learn new developments related to all aspects of nephrology, and are designed for nephrologists in the private sector and academia, fellows and residents with a special interest in kidney disease, general internists, pharmacists, physician assistants, nurse practitioners, nurses and technicians, social workers, and renal and clinical dietitians. In a session entitled “Special Issues in Minority Populations,” the NKF will provide a forum for discussion of “Dialysis of Undocumented Immigrants,” among other topics. The following article presents the viewpoint of Rudy A. Rodriguez, MD, who will be speaking at that session. Dial.
A Photo‐Caged Platinum(II) Complex That Increases Cytotoxicity upon Light Activation
Authors: Ciesienski Katie L. , Hyman Lynne M. , Yang Daniel T. , Haas Kathryn L. , Dickens Marina G. , Holbrook Robert J. , Franz Katherine J. 
Published: April 2010

AbstractA novel platinum(II) photocaged complex called [Pt(cage)] has been prepared and characterized by X‐ray crystallography. The complex contains a photolabile nitrophenyl group incorporated into the backbone of a tetradentate ligand that contains two pyridyl and two amide nitrogen donor sites. The intact complex is unreactive toward ligand‐exchange reactions until activation with UV light cleaves the ligand backbone, releasing a PtII complex that more readily exchanges its ligands, as verified by reaction with a methionine‐containing peptide. [Pt(cage)] is non‐toxic to MCF‐7 cells in the dark, whereas brief UV exposure induces cell death of human breast cancer MCF‐7 cells at a level approaching that of cisplatin. By using light to alter the coordination chemistry around the metal center, [Pt(cage)] represents a new strategy for potentially delivering metal‐based drugs in a site and time specific manner.
The mitochondrial proteome: A dynamic functional program in tissues and disease states
Authors: Balaban Robert S. 
Published: April 2010

AbstractThe nuclear DNA transcriptional programming of the mitochondria proteome varies dramatically between tissues depending on its functional requirements. This programming generally regulates all of the proteins associated with a metabolic or biosynthetic pathway associated with a given function, essentially regulating the maximum rate of the pathway while keeping the enzymes at the same molar ratio. This may permit the same regulatory mechanisms to function at low‐ and high‐flux capacity situations. This alteration in total protein content results in rather dramatic changes in the mitochondria proteome between tissues. A tissues mitochondria proteome also changes with disease state, in Type 1 diabetes the liver mitochondrial proteome shifts to support ATP production, urea synthesis, and fatty acid oxidation. Acute flux regulation is modulated by numerous posttranslational events that also are highly variable between tissues. The most studied posttranslational modification is protein phosphorylation, which is found all of the complexes of oxidative phosphorylation and most of the major metabolic pathways. The functional significance of these modifications is currently a major area of research along with the kinase and phosphatase regulatory network. This near ubiquitous presence of protein phosphorylations, and other posttranslational events, in the matrix suggest that not all posttranslational events have functional significance. Screening methods are being introduced to detect the active or dynamic posttranslational sites to focus attention on sites that might provide insight into regulatory mechanisms. Environ. Mol. Mutagen., 2010. Published 2010 Wiley‐Liss, Inc.
Determining the molecular interactions of perfluorinated carboxylic acids with human sera and isolated human serum albumin using nuclear magnetic resonance spectroscopy
Authors: D'eon Jessica C. , Simpson André J. , Kumar Rajeev , Baer Andrew J. , Mabury Scott A. 
Published: April 2010

AbstractPerfluorooctanoate (PFOA) is ubiquitous in North American human sera and has a serum half-life of 3.5 years in humans. The molecular interactions that lead to the bioaccumulation of these hydrophobic and lipophobic molecules in human blood are not well understood. Perfluorohexanoic acid (PFHxA) and PFOA were used as model perfluorinated carboxylic acids (PFCAs) to characterize the major site of PFCA interaction in human sera. Using novel heteronuclear saturation transfer difference nuclear magnetic resonance spectroscopy experiments, human serum albumin (HSA) was identified as the major site of interaction for both PFHxA and PFOA in human sera. Heteronuclear single quantum coherence nuclear magnetic resonance experiments were then performed to interrogate site-specific interactions of PFHxA and PFOA with isolated HSA. Perfluorohexanoic acid was found to bind specifically to Sudlow's drug-binding site II, whereas PFOA interacted preferentially with Sudlow's drug-binding site I at the lower concentration, with additional interactions developing at the higher concentration. These experiments highlight the utility of nuclear magnetic resonance spectrometry as a tool to observe the in situ interactions of chemical contaminants with biological systems. Both PFCAs displaced the endogenous HSA ligand oleic acid at concentrations lower than observed for the drugs ibuprofen and phenylbutazone, which are established HSA ligands. Interactions between PFCAs and HSA may affect the pharmacokinetics and distribution of fatty acids and certain drugs in the human body and warrant further investigation. Environ. Toxicol. Chem. 2010; 29:1678–1688. © 2010 SETAC
Early parietal response in episodic retrieval revealed with MEG
Authors: Seibert Tyler M. , Hagler Donald J. , Brewer James B. 
Published: April 2010

AbstractRecent neuroimaging and lesion studies have led to competing hypotheses for potential roles of the left lateral parietal lobe in episodic memory retrieval. These hypotheses may be dissociated by whether they imply a role in preretrieval or postretrieval processes. For example, one hypothesis is the left parietal cortex (particularly in more ventral subregions) forms part of an “episodic buffer” that supports the online representation of the retrieved target, a role that is, by definition, postretrieval. An alternate view maintains parietal activity (particularly in more dorsal subregions) contributes to top‐down orientation of attention to retrieval search, a preretrieval role. The present investigation seeks to reveal the earliest onset of lateral parietal activity in three anatomically‐defined subregions of the left lateral parietal cortex to identify any preretrieval activation. Subjects performed a pair‐cued recall task while neural activity was recorded with magnetoencephalography (MEG) at millisecond temporal resolution. MEG data were then mapped to each subject's cortical surface using dynamic statistical parametric mapping (dSPM). Both dorsal and ventral regions showed retrieval‐related activations beginning within ∼100 ms of the cue to retrieve and lasting up to 400 ms. We conclude that this early and transient pattern of activity in lateral parietal cortex is most consistent with a preretrieval role, possibly in directing attention to episodic memory retrieval. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
β‐Band correlates of the fMRI BOLD response
Authors: Stevenson Claire M. , Brookes Matthew J. , Morris Peter G. 
Published: April 2010

AbstractOscillatory activity in the β‐band (15–30 Hz) has been studied in detail in the sensorimotor cortex. It has been postulated that β‐activity acts as a localized gating of cortical activity. Here, the induced oscillatory response in the β‐band is measured by magnetoencephalography, and the hemodynamic response is measured by fMRI. We assess the linearity of the responses to stimuli of varying duration in the primary motor cortex and to a sinusoidal drifting grating of varying contrast amplitude and drift frequency in the visual cortex. In this way, we explore the nature of β‐oscillations and their relationship with hemodynamic effects. Excellent spatial colocalization of BOLD and β‐activity in both central and lateral (MT) visual areas and sensorimotor areas suggests that the two are intimately related. In contrast to the BOLD response, the level of β‐desynchronization is not modulated by stimulus contrast or by stimulus duration, consistent with a gating role. The amplitude of β‐desynchronization in the central visual area is however modulated by drift frequency, and this seems to parallel the modulation in BOLD amplitude at the same location. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Reward and motivation systems: A brain mapping study of early‐stage intense romantic love in Chinese participants
Authors: Xu Xiaomeng , Aron Arthur , Brown Lucy , Cao Guikang , Feng Tingyong , Weng Xuchu 
Published: April 2010

AbstractEarly‐stage romantic love has been studied previously in the United States and United Kingdom (Aron et al. [2005]: J Neurophysiol 94:327–337; Bartels and Zeki [2000]: Neuroreport 11:3829–3834; Ortigue et al. [2007]: J Cogn Neurosci 19:1218–1230), revealing activation in the reward and motivation systems of the brain. In this study, we asked what systems are activated for early‐stage romantic love in Easterners, specifically Chinese participants? Are these activations affected by individual differences within a cultural context of Traditionality and Modernity? Also, are these brain activations correlated with later satisfaction in the relationship? In Beijing, we used the same procedure used by Aron et al. (Aron et al. [2005]: J Neurophysiol 94:327–337). The stimuli for 18 Chinese participants were a picture of the face of their beloved, the face of a familiar acquaintance, and a countback task. We found significant activations specific to the beloved in the reward and motivation systems, particularly, the ventral tegmental area and the caudate. The mid‐orbitofrontal cortex and cerebellum were also activated, whereas amygdala, medial orbitofrontal, and medial accumbens activity were decreased relative to the familiar acquaintance. Self‐reported Traditionality and Modernity scores were each positively correlated with activity in the nucleus accumbens, although in different regions and sides of the brain. Activity in the subgenual area and the superior frontal gyrus was associated with higher relationship happiness at 18‐month follow‐up. Our results show that midbrain dopamine‐rich reward/motivation systems were activated by early‐stage romantic love in Chinese participants, as found by other studies. Neural activity was associated with Traditionality and Modernity attitudes as well as with later relationship happiness for Chinese participants. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Implicit sequence‐specific motor learning after subcortical stroke is associated with increased prefrontal brain activations: An fMRI Study
Authors: Meehan Sean K. , Randhawa Bubblepreet , Wessel Brenda , Boyd Lara A. 
Published: April 2010

AbstractImplicit motor learning is preserved after stroke, but how the brain compensates for damage to facilitate learning is unclear. We used a random effects analysis to determine how stroke alters patterns of brain activity during implicit sequence‐specific motor learning as compared to general improvements in motor control. Nine healthy participants and nine individuals with chronic, right focal subcortical stroke performed a continuous joystick‐based tracking task during an initial functional magnetic resonance images (fMRI) session, over 5 days of practice, and a retention test during a separate fMRI session. Sequence‐specific implicit motor learning was differentiated from general improvements in motor control by comparing tracking performance on a novel, repeated tracking sequence during early practice and again at the retention test. Both groups demonstrated implicit sequence‐specific motor learning at the retention test, yet substantial differences were apparent. At retention, healthy control participants demonstrated increased blood oxygenation level dependent (BOLD) response in left dorsal premotor cortex (PMd; BA 6) but decreased BOLD response left dorsolateral prefrontal cortex (DLPFC; BA 9) during repeated sequence tracking. In contrast, at retention individuals with stroke did not show this reduction in DLPFC during repeated tracking. Instead implicit sequence‐specific motor learning and general improvements in motor control were associated with increased BOLD response in the left middle frontal gyrus BA 8, regardless of sequence type after stroke. These data emphasize the potential importance of a prefrontal‐based attentional network for implicit motor learning after stroke. This study is the first to highlight the importance of the prefrontal cortex for implicit sequence‐specific motor learning after stroke. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Double dissociation between syntactic gender and picture naming processing: A brain stimulation mapping study
Authors: Vidorreta Jose Garbizu , Garcia Roser , Moritz‐Gasser Sylvie , Duffau Hugues 
Published: April 2010

AbstractNeural foundations of syntactic gender processing remain poorly understood. We used electrostimulation mapping in nine right‐handed awake patients during surgery for a glioma within the left hemisphere, to study whether the cortico‐subcortical structures involved in naming versus syntactic gender processing are common or distinct. In French, the article determines the grammatical gender. Thus, the patient was asked to perform a picture naming task and to give the appropriate article for each picture, with and without stimulation. Cortical stimulation elicited reproducible syntactic gender disturbances in six patients, in the inferior frontal gyrus (three cases), and in the posterior middle temporal gyrus (three cases). Interestingly, no naming disorders were generated during stimulation of the syntactic sites, while cortical areas inducing naming disturbances never elicited grammatical gender errors when stimulated. Moreover, at the subcortical level, stimulation of the white matter lateral to the caudate nucleus induced gender errors in three patients, with no naming disorders. Using cortico‐subcortical electrical mapping in awake patients, we demonstrate for the first time (1) a double dissociation between syntactic gender and naming processing, supporting independent network model rather than serial theory, (2) the involvement of the left inferior frontal gyrus, especially the pars triangularis, and the posterior left middle temporal gyrus in grammatical gender processing, (3) the existence of white matter pathways, likely a sub‐part of the left superior longitudinal fasciculus, underlying a large‐scale distributed cortico‐subcortical circuit which might selectively sub‐serve syntactic gender processing, even if interconnected with parallel sub‐networks involved in naming (semantic and phonological) processing. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
An executive's guide to SOX audits
Authors: Paul Jack W. 
Published: April 2010

AbstractAuditors aren't the only ones who need a sharp understanding of internal control audits. Savvy CEOs and other executives also need this knowledge—to save time, money, and even professional careers. Because, as most readers know, CEOs and CFOs must now certify the veracity of their company's financial statements—under threat of heavy criminal penalties.So, how thorough is your knowledge about internal control audits? Let the author of this article lead you step by step through the process, as he offers advice on avoiding pitfalls and points out possible warning signs. © 2010 Wiley Periodicals, Inc.
IRS victory jeopardizes workpaper confidentiality
Authors: Sonnier Blaise M. 
Published: April 2010

AbstractA decision by the First Circuit Court of Appeals was a dismaying surprise to many observers. It sets a new stringent standard to claim confidentiality for tax accrual and other workpapers. What is the impact of this startling decision? What can companies do now to retain privacy for workpapers? The author examines the issues and offers some practical advice. © 2010 Wiley Periodicals, Inc.
Branch migration of Holliday junction in RuvA tetramer complex studied by umbrella sampling simulation using a path‐search algorithm
Authors: Ishida Hisashi 
Published: April 2010

AbstractBranch migration of the Holliday junction takes place at the center of the RuvA tetramer. To elucidate how branch migration occurs, umbrella sampling simulations were performed for complexes of the RuvA tetramer and Holliday junction DNA. Although conventional umbrella sampling simulations set sampling points a priori, the umbrella sampling simulation in this study set the sampling points one by one in order to search for a realistic path of the branch migration during the simulations. Starting from the X‐ray structure of the complex, in which the hydrogen bonds between two base‐pairs were unformed, the hydrogen bonds between the next base‐pairs of the shrinking stems were observed to start to disconnect. At the intermediate stage, three or four of the eight unpaired bases interacted closely with the acidic pins from RuvA. During the final stage, these bases moved away from the pins and formed the hydrogen bonds of the new base‐pairs of the growing stems. The free‐energy profile along this reaction path showed that the intermediate stage was a meta‐stable state between two free‐energy barriers of about 10 to 15 kcal/mol. These results imply that the pins play an important role in stabilizing the interactions between the pins and the unpaired base‐pairs. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010
Parallel Fock matrix construction with distributed shared memory model for the FMO‐MO method
Authors: Umeda Hiroaki , Inadomi Yuichi , Watanabe Toshio , Yagi Toru , Ishimoto Takayoshi , Ikegami Tsutomu , Tadano Hiroto , Sakurai Tetsuya , Nagashima Umpei 
Published: April 2010

AbstractA parallel Fock matrix construction program for FMO‐MO method has been developed with the distributed shared memory model. To construct a large‐sized Fock matrix during FMO‐MO calculations, a distributed parallel algorithm was designed to make full use of local memory to reduce communication, and was implemented on the Global Array toolkit. A benchmark calculation for a small system indicates that the parallelization efficiency of the matrix construction portion is as high as 93% at 1,024 processors. A large FMO‐MO application on the epidermal growth factor receptor (EGFR) protein (17,246 atoms and 96,234 basis functions) was also carried out at the HF/6‐31G level of theory, with the frontier orbitals being extracted by a Sakurai‐Sugiura eigensolver. It takes 11.3 h for the FMO calculation, 49.1 h for the Fock matrix construction, and 10 min to extract 94 eigen‐components on a PC cluster system using 256 processors. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010
Solving the low dimensional Smoluchowski equation with a singular value basis set
Authors: Scott Gregory , Gruebele Martin 
Published: April 2010

AbstractReaction kinetics on free energy surfaces with small activation barriers can be computed directly with the Smoluchowski equation. The procedure is computationally expensive even in a few dimensions. We present a propagation method that considerably reduces computational time for a particular class of problems: when the free energy surface suddenly switches by a small amount, and the probability distribution relaxes to a new equilibrium value. This case describes relaxation experiments. To achieve efficient solution, we expand the density matrix in a basis set obtained by singular value decomposition of equilibrium density matrices. Grid size during propagation is reduced from (100–1000)N to (2–4)N in N dimensions. Although the scaling with N is not improved, the smaller basis set nonetheless yields a significant speed up for low‐dimensional calculations. To demonstrate the practicality of our method, we couple Smoluchowsi dynamics with a genetic algorithm to search for free energy surfaces compatible with the multiprobe thermodynamics and temperature jump experiment reported for the protein α3D. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2010