bluuebunny/crossref_metadata_2025_split huggingface dataset:
ЗАСТОСУВАННЯ ПЛАВАННЯ У ПОЛІПШЕННІ ФУНКЦІОНАЛЬНОГО СТАНУ ОПОРНО-РУХОВОГО АПАРАТУ У ДІТЕЙ 8-9 РОКІВ ЗІ СКОЛІОЗОМ
Authors: ОДИНЕЦЬ Тетяна , ПОРИВАЄВА Вікторія 
Published: May 2024

Позитивний вплив водного плавання на корекцію сколіозу у дітей відзначається завдяки гідродинамічного тиску, який рівномірно розподіляється по поверхні тіла. Це сприяє підтримці хребта та зменшенню навантаження на м'язи та суглоби, що особливо важливо при сколіозі. Мета дослідження: теоретично обґрунтувати особливості застосування плавання у поліпшенні функціонального стану опорно-рухового апарату у дітей 8-9 років зі сколіозом. Методи дослідження. В роботі були застосовані методи теоретичного рівня дослідження: аналіз, порівняння, індукція, дедукція, систематизація та узагальнення науково-методичної літератури. Результати роботи. Плавання, використовуване для корекції сколіозу, представляє собою науково обґрунтований метод реабілітації, який використовує водне середовище для поліпшення фізичної форми та зниження симптомів хребетно-м'язових захворювань. Вправи у воді, крім їх коригувальних функцій, досягнутих за допомогою середовища, що характеризуються більшим опором, позитивно впливають на підвищення сили та витривалості у дітей зі сколіозом. Дослідження показали, що діти, які займаються плаванням, досягли значно кращих значень функціонального стану системи зовнішнього дихання, зменшення кривизни кута сколіозу та вигинів хребта в саггітальній площині. Висновки. Таким чином, плавання стає важливим інструментом в реабілітації дітей із сколіозом, допомагаючи вирішувати фізичні проблеми та поліпшувати їх загальний стан. Цей метод заснований на принципах гідродинамічного тиску та сприяє всебічному фізичному розвитку дітей, підвищуючи їхню якість життя і функціональний стан опорно-рухового апарату.
AS FORMAS JURÍDICAS, SUA RELAÇÃO COM AS PESSOAS COM DEFICIÊNCIA E A CRIMINALIDADE.
Authors: Corrêa de Mello Júnior , Bonin Joel Cezar , Castilho Lopes Lucas , Emilio Zart Ricardo 
Published: May 2024

O presente artigo se propõe a discutir a interrelação entre as pessoas com deficiências, seus crimes e as normas jurídicas. Em um primeiro momento, será apresentada uma breve incursão ao pensamento de Michel Foucault, principalmente por meio da obra “A verdade e as formas jurídicas” (2003), resultado de um seminário ministrado em 1973 na PUC-Rio. Essa obra pode ser considerada seminal, pois ela foi o pontapé inicial para a publicação de sua obra mais singular sobre as prisões - “Vigiar e Punir”, publicada originalmente em 1975 pelas Edições Gallimard, na França e em 1977, pela Editora Vozes, no Brasil. A obra de 1973 já apresenta elementos importantes para a compreensão do nascimento das prisões e as mudanças a partir do Século XIX sobre o formato das punições. Com base nesta fundamentação, no segundo momento, aborda-se a problemática dos encarcerados com deficiência nos presídios nacionais. O intento é mostrar os dilemas e negligências que este público sofre ao viver sem o mínimo razoável no mundo do cárcere. A metodologia é bibliográfica e adotou-se a análise qualitativa dos dados compilados. Ao final, aponta-se para a necessidade do incremento de leis e políticas públicas voltadas para o atendimento deste público, haja vista, que mesmo as pessoas “normais” em situação de privação de liberdade, encontram-se esquecidas ou abandonadas à própria sorte na realidade prisional de nosso país.

PALAVRAS CHAVE: Normas jurídicas, pessoas com deficiência, criminalidade.
ABSTRACT
This article aims to discuss the interrelationship between people with disabilities, their crimes and legal norms. Initially, a brief foray into Michel Foucault's thought will be presented, mainly through the work “Truth and legal forms” (2003), the result of a seminar given in 1973 at PUC-Rio. This work can be considered seminal, as it was the starting point for the publication of his most unique work on prisons - “Discipline and Punish”, originally published in 1975 by Gallimard Editions, in France and in 1977, by Vozes Library, in Brazil. The 1973’s work already presents important elements for understanding the birth of prisons and the changes in the format of punishments from the 19th century onwards. Based on this foundation, in the second stage, the problem of inmates with disabilities in national prisons is addressed. The intention is to show the dilemmas and negligence that this public suffers when living without a reasonable minimum in the world of prison. The methodology is bibliographic and reflects the qualitative analysis of the compiled data. In the end, it points to the need to increase laws and external public policies to serve this public, as even “normal” people in situations of deprivation of liberty find themselves forgotten or abandoned to their own devices. in the prison reality of our country.

Keywords: Legal standards, people with disabilities, crime.
FAIR compliant database development for human microbiome data samples
Authors: Dorst Mathieu , Zeevenhooven Nathan , Wilding Rory , Mende Daniel , Brandt Bernd W. , Zaura Egija , Hoekstra Alfons , Sheraton Vivek M. 
Published: May 2024

IntroductionSharing microbiome data among researchers fosters new innovations and reduces cost for research. Practically, this means that the (meta)data will have to be standardized, transparent and readily available for researchers. The microbiome data and associated metadata will then be described with regards to composition and origin, in order to maximize the possibilities for application in various contexts of research. Here, we propose a set of tools and protocols to develop a real-time FAIR (Findable. Accessible, Interoperable and Reusable) compliant database for the handling and storage of human microbiome and host-associated data.MethodsThe conflicts arising from privacy laws with respect to metadata, possible human genome sequences in the metagenome shotgun data and FAIR implementations are discussed. Alternate pathways for achieving compliance in such conflicts are analyzed. Sample traceable and sensitive microbiome data, such as DNA sequences or geolocalized metadata are identified, and the role of the GDPR (General Data Protection Regulation) data regulations are considered. For the construction of the database, procedures have been realized to make data FAIR compliant, while preserving privacy of the participants providing the data.Results and discussionAn open-source development platform, Supabase, was used to implement the microbiome database. Researchers can deploy this real-time database to access, upload, download and interact with human microbiome data in a FAIR complaint manner. In addition, a large language model (LLM) powered by ChatGPT is developed and deployed to enable knowledge dissemination and non-expert usage of the database.
Survival, but not the severity of hypoxic–ischemic encephalopathy, is associated with higher mean arterial blood pressure after cardiac arrest: a retrospective cohort study
Authors: Preuß Sandra , Multmeier Jan , Stenzel Werner , Major Sebastian , Ploner Christoph J. , Storm Christian , Nee Jens , Leithner Christoph , Endisch Christian 
Published: May 2024

BackgroundThis study investigates the association between the mean arterial blood pressure (MAP), vasopressor requirement, and severity of hypoxic–ischemic encephalopathy (HIE) after cardiac arrest (CA).MethodsBetween 2008 and 2017, we retrospectively analyzed the MAP 200 h after CA and quantified the vasopressor requirements using the cumulative vasopressor index (CVI). Through a postmortem brain autopsy in non-survivors, the severity of the HIE was histopathologically dichotomized into no/mild and severe HIE. In survivors, we dichotomized the severity of HIE into no/mild cerebral performance category (CPC) 1 and severe HIE (CPC 4). We investigated the regain of consciousness, causes of death, and 5-day survival as hemodynamic confounders.ResultsAmong the 350 non-survivors, 117 had histopathologically severe HIE while 233 had no/mild HIE, without differences observed in the MAP (73.1 vs. 72.0 mmHg, pgroup = 0.639). Compared to the non-survivors, 211 patients with CPC 1 and 57 patients with CPC 4 had higher MAP values that showed significant, but clinically non-relevant, MAP differences (81.2 vs. 82.3 mmHg, pgroup &lt; 0.001). The no/mild HIE non-survivors (n = 54), who regained consciousness before death, had higher MAP values compared to those with no/mild HIE (n = 179), who remained persistently comatose (74.7 vs. 69.3 mmHg, pgroup &lt; 0.001). The no/mild HIE non-survivors, who regained consciousness, required fewer vasopressors (CVI 2.1 vs. 3.6, pgroup &lt; 0.001). Independent of the severity of HIE, the survivors were weaned faster from vasopressors (CVI 1.0).ConclusionsAlthough a higher MAP was associated with survival in CA patients treated with a vasopressor-supported MAP target above 65 mmHg, the severity of HIE was not. Awakening from coma was associated with less vasopressor requirements. Our results provide no evidence for a MAP target above the current guideline recommendations that can decrease the severity of HIE.
Changes in left atrial function following two regimens of combined exercise training in patients with ischemic cardiomyopathy: a pilot study
Authors: Caminiti Giuseppe , Volterrani Maurizio , Iellamo Ferdinando , Marazzi Giuseppe , Manzi Vincenzo , D’Antoni Valentino , Vadalà Sara , Di Biasio Deborah , Catena Matteo , Morsella Valentina , Perrone Marco Alfonso 
Published: May 2024

PurposeLeft atrial dysfunction has shown to play a prognostic role in patients with ischemic cardiomyopathy (ICM) and is becoming a therapeutic target for pharmacological and non-pharmacological interventions. The effects of exercise training on the atrial function in patients with ICM have been poorly investigated. In the present study, we assessed the effects of a 12-week combined training (CT) program on the left atrial function in patients with ICM.MethodsWe enlisted a total of 45 clinically stable patients and randomly assigned them to one of the following three groups: 15 to a supervised CT with low-frequency sessions (twice per week) (CTLF); 15 to a supervised CT with high-frequency sessions (thrice per week) (CTHF); and 15 to a control group following contemporary preventive exercise guidelines at home. At baseline and 12 weeks, all patients underwent a symptom-limited exercise test and echocardiography. The training included aerobic continuous exercise and resistance exercise. The analysis of variance (ANOVA) was used to compare within- and inter-group changes.ResultsAt 12 weeks, the CTLF and CTHF groups showed a similar increase in the duration of the ergometric test compared with the control (ANOVA p &lt; 0.001). The peak atrial longitudinal strain significantly increased in the CTHF group, while it was unchanged in the CTLF and control groups (ANOVA p = 0.003). The peak atrial contraction strain presented a significant improvement in the CTHF group compared with the CTLF and control groups. The left ventricular global longitudinal strain significantly increased in both the CTHF and the CTLF groups compared with the control group (ANOVA p = 0.017). The systolic blood pressure decreased in the CTHF and CTLF groups, while it was unchanged in the control group. There were no side effects causing the discontinuation of the training.ConclusionsWe demonstrated that a CT program effectively improved atrial function in patients with ICM in a dose–effect manner. This result can help with programming exercise training in this population.
Herpes virus entry mediator signaling blockade produces mortality in neonatal sepsis through induced cardiac dysfunction
Authors: Wakeley Michelle E. , Denning Naomi-Liza , Jiang Jihong , De Paepe Monique E. , Chung Chun-Shiang , Wang Ping , Ayala Alfred 
Published: May 2024

IntroductionSepsis remains a major source of morbidity and mortality in neonates, and characterization of immune regulation in the neonatal septic response remains limited. HVEM is a checkpoint regulator which can both stimulate or inhibit immune responses and demonstrates altered expression after sepsis. We hypothesized that signaling via HVEM would be essential for the neonatal response to sepsis, and that therefore blockade of this pathway would improve survival to septic challenge.MethodsTo explore this, neonatal mice were treated with cecal slurry (CS), CS with Anti-HVEM antibody (CS-Ab) or CS with isotype (CS-IT) and followed for 7-day survival. Mice from all treatment groups had thymus, lung, kidney and peritoneal fluid harvested, weighed, and stained for histologic evaluation, and changes in cardiac function were assessed with echocardiography.ResultsMortality was significantly higher for CS-Ab mice (72.2%) than for CS-IT mice (22.2%). CS resulted in dysregulated alveolar remodeling, but CS-Ab lungs demonstrated significantly less dysfunctional alveolar remodeling than CS alone (MCL 121.0 CS vs. 87.6 CS-Ab), as well as increased renal tubular vacuolization. No morphologic differences in alveolar septation or thymic karyorrhexis were found between CS-Ab and CS-IT. CS-Ab pups exhibited a marked decrease in heart rate (390.3 Sh vs. 342.1 CS-Ab), stroke volume (13.08 CS-IT vs. 8.83 CS-Ab) and ultimately cardiac output (4.90 Sh vs. 3.02 CS-Ab) as well as a significant increase in ejection fraction (73.74 Sh vs. 83.75 CS-Ab) and cardiac strain (40.74 Sh vs. 51.16 CS-Ab) as compared to CS-IT or Sham animals.DiscussionWhile receptor ligation of aspects of HVEM signaling, via antibody blockade, appears to mitigate aspects of lung injury and thymic involution, stimulatory signaling via HVEM still seems to be necessary for vascular and hemodynamic resilience and overall neonatal mouse survival in response to this experimental polymicrobial septic insult. This dissonance in the activity of anti-HVEM neutralizing antibody in neonatal animals speaks to the differences in how septic cardiac dysfunction should be considered and approached in the neonatal population.
Identification of immune subsets with distinct lectin binding signatures using multi-parameter flow cytometry: correlations with disease activity in systemic lupus erythematosus
Authors: Szabó Enikő , Faragó Anna , Bodor Gergely , Gémes Nikolett , Puskás László G. , Kovács László , Szebeni Gábor J. 
Published: May 2024

ObjectivesCell surface glycosylation can influence protein-protein interactions with particular relevance to changes in core fucosylation and terminal sialylation. Glycans are ligands for immune regulatory lectin families like galectins (Gals) or sialic acid immunoglobulin-like lectins (Siglecs). This study delves into the glycan alterations within immune subsets of systemic lupus erythematosus (SLE).MethodsEvaluation of binding affinities of Galectin-1, Galectin-3, Siglec-1, Aleuria aurantia lectin (AAL, recognizing core fucosylation), and Sambucus nigra agglutinin (SNA, specific for α-2,6-sialylation) was conducted on various immune subsets in peripheral blood mononuclear cells (PBMCs) from control and SLE subjects. Lectin binding was measured by multi-parameter flow cytometry in 18 manually gated subsets of T-cells, NK-cells, NKT-cells, B-cells, and monocytes in unstimulated resting state and also after 3-day activation. Stimulated pre-gated populations were subsequently clustered by FlowSOM algorithm based on lectin binding and activation markers, CD25 or HLA-DR.ResultsElevated AAL, SNA and CD25+/CD25- SNA binding ratio in certain stimulated SLE T-cell subsets correlated with SLE Disease Activity Index 2000 (SLEDAI-2K) scores. The significantly increased frequencies of activated AALlow Siglec-1low NK metaclusters in SLE also correlated with SLEDAI-2K indices. In SLE, activated double negative NKTs displayed significantly lower core fucosylation and CD25+/CD25- Siglec-1 binding ratio, negatively correlating with disease activity. The significantly enhanced AAL binding in resting SLE plasmablasts positively correlated with SLEDAI-2K scores.ConclusionAlterations in the glycosylation of immune cells in SLE correlate with disease severity, which might represent potential implications in the pathogenesis of SLE.
Mathematical modelling of stem and progenitor cell dynamics during ruxolitinib treatment of patients with myeloproliferative neoplasms
Authors: Boklund Tobias Idor , Snyder Jordan , Gudmand-Hoeyer Johanne , Larsen Morten Kranker , Knudsen Trine Alma , Eickhardt-Dalbøge Christina Schjellerup , Skov Vibe , Kjær Lasse , Hasselbalch Hans C. , Andersen Morten , Ottesen Johnny T. , Stiehl Thomas 
Published: May 2024

IntroductionThe Philadelphia chromosome-negative myeloproliferative neoplasms are a group of slowly progressing haematological malignancies primarily characterised by an overproduction of myeloid blood cells. Patients are treated with various drugs, including the JAK1/2 inhibitor ruxolitinib. Mathematical modelling can help propose and test hypotheses of how the treatment works.Materials and methodsWe present an extension of the Cancitis model, which describes the development of myeloproliferative neoplasms and their interactions with inflammation, that explicitly models progenitor cells and can account for treatment with ruxolitinib through effects on the malignant stem cell response to cytokine signalling and the death rate of malignant progenitor cells. The model has been fitted to individual patients’ data for the JAK2 V617F variant allele frequency from the COMFORT-II and RESPONSE studies for patients who had substantial reductions (20 percentage points or 90% of the baseline value) in their JAK2 V617F variant allele frequency (n = 24 in total).ResultsThe model fits very well to the patient data with an average root mean square error of 0.0249 (2.49%) when allowing ruxolitinib treatment to affect both malignant stem and progenitor cells. This average root mean square error is much lower than if allowing ruxolitinib treatment to affect only malignant stem or only malignant progenitor cells (average root mean square errors of 0.138 (13.8%) and 0.0874 (8.74%), respectively).DiscussionSystematic simulation studies and fitting of the model to the patient data suggest that an initial reduction of the malignant cell burden followed by a monotonic increase can be recapitulated by the model assuming that ruxolitinib affects only the death rate of malignant progenitor cells. For patients exhibiting a long-term reduction of the malignant cells, the model predicts that ruxolitinib also affects stem cell parameters, such as the malignant stem cells’ response to cytokine signalling.
A novel Chilean salmon fish backbone-based nanoHydroxyApatite functional biomaterial for potential use in bone tissue engineering
Authors: Muñoz F. , Haidar Z. S. , Puigdollers A. , Guerra I. , Padilla M. Cristina , Ortega N. , García M. J. 
Published: May 2024

IntroductionGiven the ensuing increase in bone and periodontal diseases and defects, de novo bone repair and/or regeneration strategies are constantly undergoing-development alongside advances in orthopedic, oro-dental and cranio-maxillo-facial technologies and improvements in bio−/nano-materials. Indeed, there is a remarkably growing need for new oro-dental functional biomaterials that can help recreate soft and hard tissues and restore function and aesthetics of teeth/ dentition and surrounding tissues. In bone tissue engineering, HydroxyApatite minerals (HAp), the most stable CaP/Calcium Phosphate bioceramic and a widely-used material as a bone graft substitute, have been extensively studied for regenerative medicine and dentistry applications, including clinical use. Yet, limitations and challenges owing principally to its bio-mechanical strength, exist and therefore, research and innovation efforts continue to pursue enhancing its bio-effects, particularly at the nano-scale.MethodsHerein, we report on the physico-chemical properties of a novel nanoHydroxyApatite material obtained from the backbone of Salmon fish (patent-pending); an abundant and promising yet under-explored alternative HAp source. Briefly, our nanoS-HAp obtained via a modified and innovative alkaline hydrolysis–calcination process was characterized by X-ray diffraction, electron microscopy, spectroscopy, and a cell viability assay.Results and DiscussionWhen compared to control HAp (synthetic, human, bovine or porcine), our nanoS-HAp demonstrated attractive characteristics, a promising biomaterial candidate for use in bone tissue engineering, and beyond.
The current state of intensive care unit discharge practices - Results of an international survey study
Authors: Hiller Maike , Burisch Christian , Wittmann Maria , Bracht Hendrik , Kaltwasser Arnold , Bakker Jan 
Published: May 2024

BackgroundIncreasing pressure on limited intensive care capacities often requires a subjective assessment of a patient's discharge readiness in the absence of established Admission, Discharge, and Transfer (ADT) guidelines. To avoid suboptimal care transitions, it is important to define clear guidelines for the admission and discharge of intensive care patients and to optimize transfer processes between the intensive care unit (ICU) and lower care levels. To achieve these goals, structured insights into usual ICU discharge and transfer practices are essential. This study aimed to generate these insights by focusing on involved stakeholders, established processes, discharge criteria and tools, relevant performance metrics, and current barriers to a timely and safe discharge.MethodIn 2022, a structured, web-based, anonymous cross-sectional survey was conducted, aimed at practicing ICU physicians, nurses, and bed coordinators. The survey consisted of 29 questions (open, closed, multiple choice, and scales) that were divided into thematic blocks. The study was supported by several national and international societies for intensive care medicine and nursing.ResultsA total of 219 participants from 40 countries (105 from Germany) participated in the survey. An overload of acute care resources with ~90% capacity utilization in the ICU and the general ward (GW) leads to not only premature but also delayed patient transfers due to a lack of available ward and intermediate care (IMC) beds. After multidisciplinary rounds within the intensive care team, the ICU clinician on duty usually makes the final transfer decision, while one-third of the panel coordinates discharge decisions across departmental boundaries. By the end of the COVID-19 pandemic, half of the hospitals had implemented ADT policies. Among these hospitals, nearly one-third of the hospitals had specific transfer criteria established, consisting primarily of vital signs and laboratory data, patient status and autonomy, and organization-specific criteria. Liaison nurses were less common but were ranked right after the required IMC capacities to bridge the care gap between the ICU and normal wards. In this study, 80% of the participants suggested that transfer planning would be easier if there was good transparency regarding the capacity utilization of lower care levels, a standardized transfer process, and improved interdisciplinary communication.ConclusionTo improve care transitions, transfer processes should be managed proactively across departments, and efforts should be made to identify and address care gaps.