bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of three‐dimensional power Doppler to predict clinical and histological response to neoadjuvant chemotherapy in locally advanced cervical carcinoma
Authors: Qin J. , Cheng X. , Chen X. , Zhang X. , Lu W. , Xie X. 
Published: August 2011

AbstractObjectivePlatinum‐based neoadjuvant chemotherapy followed by radical hysterectomy is an alternative therapeutic strategy for locally advanced cervical carcinoma but variables used to predict chemotherapy response are not well defined. We investigated the potential of three‐dimensional (3D) power Doppler in predicting response to neoadjuvant chemotherapy.MethodsWe enrolled 61 eligible patients with locally advanced cervical carcinoma who underwent neoadjuvant chemotherapy followed by surgery or radiation. Before the initial chemotherapy, we measured 3D power Doppler vascular indices, including vascularization index (VI), flow index (FI) and vascularization flow index (VFI), of the whole cervical carcinoma. We also measured two‐dimensional (2D) hemodynamic parameters, such as resistance index and pulsatility index, at three random spots inside the tumor. The associations of all parameters with clinical and histological responses to chemotherapy were evaluated through univariable and multiple logistic regression analysis.ResultsThe clinical and histological response rates to chemotherapy were 70.5% and 70.7%, respectively. Univariable logistic regression analysis showed that VI, FI and VFI were significantly higher in clinical responders than in non‐responders (P < 0.05), and that FI was significantly higher in histological responders (P = 0.012). Multiple logistic regression analysis showed that FI was the only significant factor associated with both clinical and histological responses. The best FI cut‐off values were 35.3 and 37.3 for clinical response and histological response, respectively (with sensitivity 86.0% and 73.2%, and specificity 72.2% and 64.7%). Interestingly, none of the 2D hemodynamic parameters was significantly correlated with either response.ConclusionFI is a potential marker for predicting both clinical and histological responses to chemotherapy in patients with locally advanced cervical carcinoma. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Treatment experiences of children and adolescents with attention‐deficit/hyperactivity disorder
Authors: Leggett Catherine , Hotham Elizabeth 
Published: August 2011

Aim:  To gain insight into the treatment experiences of children and adolescents diagnosed with attention‐deficit/hyperactivity disorder (ADHD).Methods:  Convenience sampling was used to recruit eligible parents and carers at paediatric clinics of the Children's, Youth and Women's Health Service to participate in an interview to discuss experiences, using a semi‐structured questionnaire.Results:  Thirty‐five interviews were conducted. Twenty‐five subjects had trialled an average of 1.5 interventions prior to receiving an ADHD diagnosis, namely, dietary modifications (46%), behavioural therapy (24%), learning assistance (8%) and natural remedies (8%). Following an ADHD diagnosis, 25 subjects tried an average of 2.8 interventions, most commonly behavioural therapies (48%), expressive therapies (48%) and fish oil (36%). All subjects started psychostimulant medication after receiving an ADHD diagnosis. Despite 52% of parents expressing initial reluctance towards psychostimulants, 97% reported positive experiences with use in terms of schooling, social interaction and family life. Of those being treated with psychostimulants, 22 (73%) were concurrently using other treatments at the time of interview.Conclusions:  Few patients use psychostimulant medication in isolation, with the majority of parents using multiple approaches to manage their child's behaviour. Parents tried a variety of therapies before commencing psychostimulant medication, often because of fears regarding psychostimulant safety. Parents were generally happy with the results gained; however adolescents interviewed were less convinced of the benefits of psychostimulants.
Positional Accuracy of TIGER 2000 and 2009 Road Networks
Authors: Zandbergen Paul A. , Ignizio Drew A. , Lenzer Kathryn E. 
Published: August 2011

AbstractThe Topologically Integrated Geographic Encoding and Referencing (TIGER) data are an essential part of the US Census and represent a critical element in the nation's spatial data infrastructure. TIGER data for the year 2000, however, are of limited positional accuracy and were deemed of insufficient quality to support the 2010 Census. In response the US Census Bureau embarked on the MAF/TIGER Accuracy Improvement Project (MTAIP) in an effort to improve the positional accuracy of the database, modernize the data processing environment and improve cooperation with partner agencies. Improved TIGER data were released for the entire US just before the 2010 Census. The current study characterizes the positional accuracy of the TIGER 2009 data compared with the TIGER 2000 data based on selected road intersections. Three US counties were identified as study areas and in each county 100 urban and 100 rural sample locations were selected. Features in the TIGER 2000 and 2009 data were compared with reference locations derived from high resolution natural color orthoimagery. Results indicate that TIGER 2009 data are much improved in terms of positional accuracy compared with the TIGER 2000 data, by at least one order of magnitude across urban and rural areas in all three counties for most accuracy metrics. TIGER 2009 is consistently more accurate in urban areas compared with rural areas, by a factor of at least two for most accuracy metrics. Despite the substantial improvement in positional accuracy, large positional errors of greater than 10 m are relatively common in the TIGER 2009 data, in most cases representing remnant segments of minor roads from older versions of the TIGER data. As a result, based on the US Census Bureau's suggested accuracy metric, the TIGER 2009 data meet the accuracy expectation of 7.6 m for two of the three urban areas but for none of the three rural areas. The suggested metric is based on the National Standard for Spatial Data Accuracy (NSSDA) protocol and was found to be very sensitive to the presence of a small number of very large errors. This presents challenges during attempts to characterize the accuracy of TIGER data or other spatial data using this protocol.
Protective effects of a magnesium magnetic isotope (Mg25)‐exchanging nanoparticle (25MgPMC16) on mitochondrial functional disorders in esmolol‐induced cardiac arrest in rats
Authors: Adeli S. , Zarrindast M. R. , Niknahad H. , Sarkar S. , Bidgoli S. A. , Korani M. , Ghasemzadeh P. , Rezayat S. M. 
Published: August 2011

Summary1 In cardiac surgery, agents are needed to produce temporary cardiac arrest (cardioplegia). One of these agents is esmolol (ESM) which is a short‐acting selective beta‐1 adrenergic receptor antagonist and its overdose causes diastolic ventricular arrest.2 The 25MgPMC16 (porphyrin adducts of cyclohexil fullerene‐C60) is known as a nanoparticle which has a cardioprotective effect when the heart is subjected to stressful conditions.3 In this study, we aimed to confirm the deleterious effects of ESM overdose on cardiac mitochondria and identify any protective effects of 25MgPMC16 in male Wistar rats. Esmolol 100 mg kg−1 (LD50 = 71 mg kg−1) was injected intravenously (i.v.) into tail vein to induce cardiac arrest. This dose was obtained from an ESM dose–response curve which induces at least 80% arrest in rats.4 25MgPMC16 at three different doses (45, 90 and 224 mg kg−1) was injected i.v. as pretreatment, eight hours before ESM injection. 25MgCl2 or 24MgPMC16 were used as controls. Following cardiac arrest, the heart was removed and the mitochondria extracted. Mitochondrial viability and the adenosine 5′‐diphosphate sodium salt hydrate/Adenosine 5′‐triphosphate disodium salt hydrate (ADP/ATP) ratio were measured as biomarkers of mitochondrial function.5 Results indicate that 25MgPMC16 caused a significant increase in mitochondrial viability and decrease in ADP/ATP ratio. No significant changes were seen with 24MgPMC16 or 25MgCl2. It is concluded that cardiac arrest induced by ESM overdose leads to a significant decrease in mitochondrial viability and their ATP levels, whereas pretreatment by 25MgPMC16 can protect mitochondria by increasing ATP level through liberation of Mg into cells and the improvement of hypoxia.
The Endothelium Modulates the Arterial Wall Mechanical Response to Intra‐Aortic Balloon Counterpulsation: In Vivo Studies
Authors: Bia Daniel , Cabrera‐Fischer Edmundo I. , Zócalo Yanina , Armentano Ricardo L. 
Published: August 2011

AbstractIntra‐aortic balloon pump (IABP) benefits could depend on variations in the cardiovascular biomechanical properties associated with blood flow‐induced endothelium‐dependent changes. However, if IABP results in changes in the peripheral artery biomechanics and if the endothelium plays a role in these potential changes remains unknown. The aim of this study is to characterize acute IABP effects on peripheral artery biomechanics in control and acute heart failure (AHF) states and the role of the endothelium in IABP effects on peripheral artery biomechanics. Pressure and diameter were recorded in sheep (n= 7) iliac arteries (IAs), before and during 1:2 IABP, during four states: (i) control with intact IA; (ii) AHF with intact IA; (iii) control with de‐endothelialized (DE) (mechanical rubbing) IA; and (iv) AHF with DE IA. Arterial distensibility, elastic modulus, and conduit function (CF) (1/characteristic impedance) were calculated. The results of this study include: (i) during control conditions, IABP resulted in intact IA dilatation, stiffness reduction, and CF increase; (ii) AHF induction determined a reduction in intact IA diameter and CF, and a stiffness increase. These changes reverted during IABP; (iii) the increase in IA stiffness observed after DE remained unchanged during IABP; (iv) in DE IA, AHF did not result in diameter or stiffness changes; and (v) IABP during AHF did not associate changes in diameter or stiffness in the DE IA. In conclusion, during control and AHF states, IABP results in IA dilatation and stiffness reduction. The integrity of the endothelial layer would be critical for the IABP‐associated changes in IA biomechanics.
Gene expression profiling of human whole blood samples with the Illumina WG-DASL assay
Authors: Winn Mary E , Shaw Marian , April Craig , Klotzle Brandy , Fan Jian-Bing , Murray Sarah S , Schork Nicholas J 
Published: August 2011

Abstract

Background
Microarray-based gene expression analysis of peripheral whole blood is a common strategy in the development of clinically relevant biomarker panels for a variety of human diseases. However, the results of such an analysis are often plagued by decreased sensitivity and reliability due to the effects of relatively high levels of globin mRNA in whole blood. Globin reduction assays have been shown to overcome such effects, but they require large amounts of total RNA and may induce distinct gene expression profiles. The Illumina whole genome DASL assay can detect gene expression levels using partially degraded RNA samples and has the potential to detect rare transcripts present in highly heterogeneous whole blood samples without the need for globin reduction. We assessed the utility of the whole genome DASL assay in an analysis of peripheral whole blood gene expression profiles.

Results
We find that gene expression detection is significantly increased with the use of whole genome DASL compared to the standard IVT-based direct hybridization. Additionally, globin-probe negative whole genome DASL did not exhibit significant improvements over globin-probe positive whole genome DASL. Globin reduction further increases the detection sensitivity and reliability of both whole genome DASL and IVT-based direct hybridization with little effect on raw intensity correlations. Raw intensity correlations between total RNA and globin reduced RNA were 0.955 for IVT-based direct hybridization and 0.979 for whole genome DASL.

Conclusions
Overall, the detection sensitivity of the whole genome DASL assay is higher than the IVT-based direct hybridization assay, with or without globin reduction, and should be considered in conjunction with globin reduction methods for future blood-based gene expression studies.
Functional neural correlates of reduced physiological falls risk
Authors: Nagamatsu Lindsay S , Hsu Chun Liang , Handy Todd C , Liu-Ambrose Teresa 
Published: August 2011

Abstract

Background
It is currently unclear whether the function of brain regions associated with executive cognitive processing are independently associated with reduced physiological falls risk. If these are related, it would suggest that the development of interventions targeted at improving executive neurocognitive function would be an effective new approach for reducing physiological falls risk in seniors.

Methods
We performed a secondary analysis of 73 community-dwelling senior women aged 65 to 75 years old who participated in a 12-month randomized controlled trial of resistance training. Functional MRI data were acquired while participants performed a modified Eriksen Flanker Task - a task of selective attention and conflict resolution. Brain volumes were obtained using MRI. Falls risk was assessed using the Physiological Profile Assessment (PPA).

Results
After accounting for baseline age, experimental group, baseline PPA score, and total baseline white matter brain volume, baseline activation in the left frontal orbital cortex extending towards the insula was negatively associated with reduced physiological falls risk over the 12-month period. In contrast, baseline activation in the paracingulate gyrus extending towards the anterior cingulate gyrus was positively associated with reduced physiological falls risk.

Conclusions
Baseline activation levels of brain regions underlying response inhibition and selective attention were independently associated with reduced physiological falls risk. This suggests that falls prevention strategies may be facilitated by incorporating intervention components - such as aerobic exercise - that are specifically designed to induce neurocognitive plasticity.

Trial Registration
ClinicalTrials.gov Identifier: NCT00426881
Immobilized Biocatalysts: Novel Approaches and Tools for Binding Enzymes to Supports
Authors: Torres‐Salas Pamela , del Monte‐Martinez Alberto , Cutiño‐Avila Bessy , Rodriguez‐Colinas Barbara , Alcalde Miguel , Ballesteros Antonio O. , Plou Francisco J. 
Published: August 2011

AbstractIn the last decade, new trends for enzyme attachment to solid carriers have emerged in an attempt to rationalize the classical methods for enzyme immobilization. In silico analysis is becoming a powerful tool to predict the orientation of enzymes covalently attached to the carrier or the protein regions involved in adsorption to the support. Significantly, an array of algorithms has been established for the rational design of immobilized derivatives, which comprises both the protein size and the textural properties of the support. Ordered mesoporous materials open a challenging pathway to tailor immobilized enzymes with high volumetric activity and minimum lixiviation. In addition, fluorescence confocal microscopy is being successfully employed to understand the diffusional restrictions and the distribution of biomolecules within the support.
Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of Cryptoporus sinensis, and Their Inhibitory Effects on Nitric Oxide Production
Authors: Wu Wen , Zhao Feng , Ding Rong , Bao Li , Gao Hao , Lu Jin‐Cai , Yao Xin‐Sheng , Zhang Xiao‐Qing , Liu Hong‐Wei 
Published: August 2011

AbstractFour new drimane‐type sesquiterpenoid ethers of isocitric acid, named cryptoporic acids J–M, were isolated from the fruiting bodies of Cryptoporus sinensis, together with six known cryptoporic acids. Their structures were elucidated on the basis of extensive spectroscopic analyses. Among them, cryptoporic acid D showed strong inhibition against nitric oxide (NO) production in macrophages with an IC50 of 45.8±3.6 μM, comparable to the positive control of hydrocortisone (IC50 of 40.6±2.5 μM).
Improved blood compatibility of Mg‐1.0Zn‐1.0Ca alloy by micro‐arc oxidation
Authors: Wang Da‐Wei , Cao Yang , Qiu Hui , Bi Zheng‐Gang 
Published: August 2011

AbstractMagnesium and its alloys have been used in the recent development of lightweight, biodegradeable implant materials. However, the corrosion properties of magnesium limit its usefulness. In a previous study, a micro‐arc oxidation (MAO) method was used to modify a Mg‐1.0 wt % Zn‐1.0 wt % Ca alloy surface, with the purpose of improving the corrosion resistance of Mg alloys. However, the blood compatibility of MAO‐treated Mg alloy is unknown. Results of cytotoxicity assays with bone marrow‐derived mesenchymal stem cells showed that extracts of MAO‐treated alloy significantly decreased cytotoxicity compared to titanium alloy extract. Results of blood compatibility tests showed that the MAO group had a decreased hemolytic ratio (2.25%) compared to the untreated Mg alloy group (24.58%) (p < 0.001). The MAO group showed significantly shorter prothrombin and thrombin times and significantly longer activated partial thromboplastin time than the untreated Mg alloy group. Arachidonic acid‐ and adenosine diphosphate‐induced platelet aggregations were significantly decreased by the untreated Mg alloy extract, and they were less affected by extract of MAO‐treated Mg alloy. In conclusion, MAO‐treated Mg‐1.0 wt % Zn‐1.0 wt % Ca alloy exhibits favorable blood compatibility characteristics and may be useful in the development of magnesium implant materials. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Centrosome dynamics during mammalian oocyte maturation with a focus on meiotic spindle formation
Authors: Schatten Heide , Sun Qing‐Yuan 
Published: August 2011

AbstractOocyte maturation is an important process required to achieve optimal oocyte quality, and later affects fertilization potential and subsequent embryo development. The maturation process includes synchronized nuclear and cytoplasmic remodeling, in which cytoskeletal and centrosome dynamics play an important role and significantly participate in cellular signaling. Centrosome remodeling within the maturing oocyte is essential for accurate meioisis I and II spindle formation, specifically to separate chromosomes accurately during the two successive, highly asymmetric meiotic cell divisions. Centrosomal abnormalities result in inaccurate microtubule organization and inaccurate chromosome alignment, with failures in chromosome segregation leading to aneuploidy and chromosomal abnormalities. The present review is focused on cytoskeletal and centrosome remodeling during oocyte maturation, with specific attention to γ‐tubulin, pericentrin, the Nuclear Mitotic Apparatus (NuMA) protein, and microtubule organization. Species‐specific differences will be discussed for rodent (mouse) and non‐rodent (bovine, porcine) species, and for human oocytes. Mol. Reprod. Dev. 78:757–768, 2011. © 2011 Wiley Periodicals, Inc.
First‐trimester detection of structural abnormalities and the role of aneuploidy markers
Authors: Grande M. , Arigita M. , Borobio V. , Jimenez J. M. , Fernandez S. , Borrell A. 
Published: August 2011

AbstractObjectivesTo determine the sensitivity of first‐trimester ultrasound for diagnosing different structural anomalies in chromosomally normal pregnancies, and to establish the role of aneuploidy markers in the detection of abnormalities.MethodsThis was a retrospective study of chromosomally normal singleton pregnancies with an 11–14‐week scan performed in our center during 2002–2009. The ultrasound examination included an early fetal anatomy survey and assessment of nuchal translucency, ductus venosus blood flow and nasal bone.ResultsAmong 13 723 scanned first‐trimester pregnancies with no genetic anomalies and complete follow‐up, 439 fetuses (3.2%) were found to present with structural anomalies (194 with major anomalies and 245 with only minor anomalies). Forty‐nine per cent of major structural anomalies were detected during the first‐trimester scan, the highest rates corresponding to acrania (17/17), holoprosencephaly (three of three), hypoplastic left heart syndrome (10/10), omphalocele (six of six), megacystis (seven of eight) and hydrops (eight of nine). Higher than expected detection rates were obtained for skeletal (69%) and cardiac (57%) defects, coincidentally showing the highest presence of an increased nuchal translucency or abnormal ductus venosus blood flow (38% and 52%, respectively). The finding of an absent nasal bone did not appear to be associated with structural defects.ConclusionAbout half of major structural abnormalities can be diagnosed in the first trimester. Increased nuchal translucency or abnormal ductus venosus blood flow appear to be associated with cardiac and skeletal defects and may facilitate early detection. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Synthesis, Structure, and Photoluminescence of a 3D Zinc(II) Coordination Polymer with Tris(2‐carboxyethyl)isocyanurate and 1,2,4‐Triazole Ligands
Authors: Fu Shuai , Zhang Guo‐Xin , Han Zheng‐Bo 
Published: August 2011

Abstract A new coordination polymer Zn2(tci)(trz)·H2O (1) [Htrz = 1,2,4‐triazole, H3tci = tris(2‐carboxyethyl)isocyanurate] was synthesized under hydrothermal conditions and characterized by elemental analysis, IR spectroscopy, TG, and single‐crystal X‐ray diffraction, which revealed that compound 1 has a 3D framework structure.
Daily hassles, physical illness, and sleep problems in older adults with wishes to die
Authors: Lapierre Sylvie , Boyer Richard , Desjardins Sophie , Dubé Micheline , Lorrain Dominique , Préville Michel , Brassard Joëlle 
Published: August 2011

ABSTRACTBackground: Factors associated with the wish to die should be investigated in order to gain more opportunities for preventive interventions targeting older adults at risk for suicide. The goal of the research was to study the prevalence and associated factors of wishes to die in older adults living in the community using the data from a survey on the prevalence of mental disorders in this population.Methods: With a representative sample of community living older adults aged 65 years and over (N = 2777), we compared individuals with the wish to die (n = 163) to those without the wish to die on the basis of the presence and severity of daily hassles, physical illness, and sleep quality.Results: Logistic regression revealed that when depression and sociodemographic variables were held constant, self-rated physical health, number of chronic illnesses, number and intensity of daily hassles, as well as sleep problems were significantly associated with the wish to die in older adults. Painful illnesses and daytime dysfunction due to sleep problems were also associated factors with the wish to die.Conclusion: Since desire for death is the first step into the suicidal process, health professionals should seriously consider the important and unique contribution of these variables in order to have more opportunities for detection and intervention.