bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Engineering of Active Fe Center in Metalloporphyrin Coupled with Polyoxometalates for Efficient Photochemical Nitrogen Fixation: Synergistic Effect of Multiactive Sites Strengthening Metal‐N‐N* Interactions
Authors: Li Ximing , Dong Qibing , Wang Junjun , Liang Xinxin , Robertson Peter K. J. , Li Fei , Guo Ming , Choi Wonyong , Wang Chuanyi 
Published: February 2025

AbstractPrecisely modulating the chemical microenvironment of catalytic centers at the molecular level to achieve efficient photocatalytic nitrogen fixation remains a grand challenge. Herein, a polyoxometalates (POMs) metalloporphyrin organic framework Fe‐PMOF {POM‐TCPP(Fe)} is constructed by integrating the oxygen‐rich unit POMs {ε‐PMo8VMo4VIO40Zn4} and the photosensitive metalloporphyrin (Fe‐TCPP) as a model to precisely regulate intermolecular electron transfer. Benefiting from electronic interactions, the optimized POM‐TCPP(Fe) exhibits a favorable activity toward NH3 production with a rate of 110.06 µmol g−1 h−1. The improved performance can be attributed to the effective regulation of the chemical microenvironment surrounding the active centers, enabling the synergistic interaction of multiple active sites (Fe and Mo) to facilitate the adsorption and activation of nitrogen. More specifically, oxygen‐rich unit POMs exhibit strong electronegativity, which can attract electrons from Fe atoms, thereby decreasing the 3d orbitals’ electron density of Fe sites and elevating its unoccupied d‐orbitals to facilitate N2 adsorption. Moreover, the porphyrin units with high photosensitivity efficiently generate electrons under photoexcitation, which can rapidly migrate and inject them to the active Fe‐N‐N* sites to facilitate N2 activation. Ultimately, the mimic nitrogenase active site intelligently integrates multiple active sites of transition metals Fe and Mo, thus improving the nitrogen fixation efficiency.
A Strong and Water‐Retaining Biomass Adhesive Inspired by Tofu
Authors: Shao Jiawei , Jing Qiumei , Li Xinyi , Shahzad Muhammad Wakil , Jiang Shuaicheng , Zhang Xuehua , Ge Shengbo , Xu Ben Bin , Li Jianzhang 
Published: February 2025

AbstractThe poor mechanical strength and low water retention of biomass adhesives present significant challenges when substituting petrochemical adhesives in practical applications. Inspired by the colloidal gel structure in Tofu, the development of a high‐performance protein‐based adhesive derived from soybean meal (SM) oxidized by glucose oxidase (GOx) and calcium sulfate oligomer (CSO) is reported. The catalytic oxidation of sugars in SM by GOx produces active carboxyl groups, increasing active sites for calcium bridge (sugar‐protein) formation in CSO. Concurrently, GOx disrupts the internal electrostatic equilibrium of SM, promoting the formation of an acid‐induced colloidal gel‐like network structure. This Tofu‐like structures can effectively minimize water evaporation and significantly enhance the interfacial adhesion. Plywood bonded with the modified adhesive demonstrates a 129% increase in wet strength compared to unmodified counterparts. Additionally, the water loss rate of modified adhesive is reduced by 30.66% at 30 minutes, while maintaining 70.37% of its initial wet strength. This enzymatically mediated organic–inorganic hybrid structure represents a promising strategy for future development of sustainable biomass adhesives.
3D Microtumors Representing Ovarian Cancer Minimal Residual Disease Respond to the Fatty Acid Oxidation Inhibitor Perhexiline
Authors: Yang Xingyun , Artibani Mara , Jin Yongcheng , Aggarwal Aneesh , Zhang Yujia , Muñoz‐Galvan Sandra , Mikhailova Ellina , Rai Lena , Mukherjee Nobina , Kumar Ravinash Krishna , Albukhari Ashwag , Ma Shaohua , Zhou Linna , Ahmed Ahmed Ashour , Bayley Hagan 
Published: February 2025

AbstractThe poor survival of ovarian cancer patients is linked to their high likelihood of relapse. In spite of full apparent macroscopic clearance, tumor recurrences arise from cells that are resistant to primary chemotherapy in the form of minimal residual disease (MRD). MRD exhibits distinct molecular drivers from bulk cancer and therefore necessitates alternative therapeutic strategies. However, there is a lack of 3D models that faithfully recapitulate MRD ex vivo for therapy development. This study constructs microfluidics‐based 3D microtumors to generate a clinically‐relevant model for ovarian cancer MRD. The microtumors recapitulate the non‐genetic heterogeneity of ovarian cancer, capturing the “Oxford Classic” five molecular signatures. Gene expression in the 3D microtumors aligns closely with MRD from ovarian cancer patients and features the upregulation of fatty acid metabolism genes. Finally, the MRD 3D microtumors respond to the approved fatty acid oxidation inhibitor, perhexiline, demonstrating their utility in drug discovery. This system might be used as a drug‐testing platform for the discovery of novel MRD‐specific therapies in ovarian cancer.
Nano Copper‐chelate Triggers Cuproptosis‐like Death in Fungi and Synergizes with Microneedles for Enhanced Biofilm Removal
Authors: Ge Xing , Deng Shuyue , Chen Lilin , Feng Feng , Fang Tianye , Ding Yu , Jiang Hui , Yang Jun , Liu Xinmei , Dai Jianjun , Yang Lei , Ju Yanmin 
Published: February 2025

AbstractFungal infections pose a significant global public health threat, particularly candidemia and biofilm formation. Current antifungal drugs have limitations due to their toxicity and drug resistance. Ion interference therapy, particularly cuproptosis, shows significant potential for disease treatment. Herein, nano copper‐chelate Cu(DDC)2@BSA (CDB) is synthesized for antifungal research and the mechanism of cuproptosis‐like death is investigated. Initially, CDB demonstrates a strong inhibitory effect on multiple fungi and exhibits strong antifungal activity against two fluconazole‐resistant clinical isolates. The decrease in ATPase activity and mitochondrial membrane potential indicates that the antifungal mechanism may involve mitochondrial dysfunction. Subsequently, transcriptome analysis reveals significant alterations in genes related to copper ions transport and regulation, oxidative phosphorylation, and mitochondrial function. Additionally, copper ions overload is observed, along with an increase in heat shock protein 70 levels and a decrease in lipoic acid synthetase protein expression. Given that biofilms hinder drug penetration, quaternary ammonium chitosan microneedles are employed in combination with CDB to penetrate the biofilm barrier and enhance the antifungal effect. Overall, this study provides new insight into the cuproptosis‐like death mechanism in fungi and presents a promising strategy for fungal infection treatment through the combination of nano copper–chelate and microneedle delivery system.
Multifunctional Hydrogel Electronics for Synergistic Therapy and Visual Monitoring in Wound Healing
Authors: Ji Yun‐Liang , Zhang Yizhou , Lu Jingqi , Gao Fan , Lv Xinyi , Qu Xinyu , Zhu Guoyin , Tian Tian , Pang Huan , Tian Yu , Dong Xiaochen 
Published: February 2025

AbstractTo overcome the limitations of precise monitoring and inefficient wound exudate management in wound healing, an advanced multifunctional hydrogel electronics (MHE) platform based on MXene@MOF/Fe3O4@C photonic crystal hydrogel is developed. This platform combines optical/electrical sensing, synergistic therapy, and real‐time visual monitoring into a single, efficient system, offering a comprehensive solution for wound healing. Under photothermal stimulation, the hydrogel releases metal ions that generate hydroxyl radicals, effectively eliminating antibiotic‐resistant bacteria. Beyond its antibacterial efficacy, this system offers unprecedented real‐time monitoring through temperature‐responsive visualization, while structural color changes upon wound exudate absorption provide a clear indication for dressing replacement. By integrating these functionalities, MHE platform allows for precise control of the therapeutic process, significantly improving wound healing and treatment monitoring. The platform's optical/electrical sensing capabilities further broaden its potential applications across other biomedical fields. This breakthrough technology provides clinicians with a powerful tool to optimize therapeutic outcomes, marking a major advancement in wound care and biomedical applications.
Fluorescence‐Switchable Iron‐Doped Nanodot Assembly as a Robust Redox Dyshomeostasis Amplifier for Noninvasive Treatment of Deep‐Seated Tumors
Authors: Xing Haiyan , Han Minyu , Zhang Tao , Zeng Guicheng , He Jie , Xu Zhigang , Kang Yuejun , Xue Peng 
Published: February 2025

AbstractCarbon dots (CDs) have been recognized as promising candidates for cancer diagnosis and therapy, owing to their intrinsic fluorescence properties and facile functionalization pathways. However, such tiny‐sized CDs tend to be rapidly excreted by the kidney and/or hepatobiliary system before reaching the tumor site, which may significantly weaken their performance in tumor theranostics. Here, fluorescence switchable iron‐doped carbon dot assemblies (FCDDs) are developed with an average size of ≈120 nm for passive tumor targeting. After lesional enrichment, FCDDs can be dissembled into Fe‐doped CDs (FCDs) with fluorescence switched on, in response to the upregulated glutathione (GSH) in the tumor microenvironment. The ultrasmall FCDs are able to penetrate into the deep region of solid tumors and generate reactive oxygen species (ROS) through the Fenton reaction. Such ROS accumulation and GSH deprivation caused by FCDDs can effectively trigger the irreversible apoptosis and ferroptosis of tumor cells. Meanwhile, the resultant intracellular redox dyshomeostasis induces prominent immunogenic cell death to prevent metastasis. Tumor‐specific fluorescence imaging not only enables cancerous tissue probing but also assists in monitoring the treatment effectiveness. Taken together, this paradigm exemplifies a practical approach to improve the functionality of CDs toward clinical applications and may inspire more facile designs toward upcoming translational medicines.
Rapid Drying Principle for High‐speed, Pinhole‐Less, Uniform Wet Deposition Protocols of Water‐Dispersed 2D Materials
Authors: Jeong Kyeonghun , Kim Chansoo , Lee Ha Young , Zhao Junyi , Choi Soo‐Hyung , Bae Jeong‐A , Kim Hyun‐Sik , Kim Jeong‐Yeon , Kim Youjin , Choi Heechae , Gorospe Alloyssius E.G. , Yoo Seung Joon , Wang Chuan , Lee Dongwook 
Published: February 2025

AbstractInexpensive, high‐speed deposition techniques that ensure uniformity, scalability, wide applicability, and tunable thickness are crucial for the practical application of 2D materials. In this work, rapid drying is identified as a key mechanism for pioneering two high‐speed wet deposition methods: hot dipping and air knife sweeping (AKS). Both techniques allow thickness control proportional to flake concentration, achieving tiled monolayers and pinhole‐free coverage across the entire substrate, as long as evaporation outpaces flake diffusion. AKS prevents non‐uniformity along substrate edges by eliminating contact line pinning. The achieved deposition speed of 0.21 m2 min−1 with AKS significantly surpasses traditional methods, enabling the equipment for large substrates > 1 m2. Combined with the ultralow debonding force for mechanically susceptible flexible display production and short‐circuit‐proof nanometer‐thin capacitors with capacitance comparable to commercial multilayer ceramic capacitors (MLCCs), these new protocols showcase simple and swift solutions for manufacturing 2D materials‐based nanodevices.
Current‐Driven Magnetization Switching for Superconducting Diode Memory
Authors: Cheng Yang , Shu Qingyuan , He Haoran , Dai Bingqian , Wang Kang L. 
Published: February 2025

AbstractStacking superconductors (SC) with ferromagnetic materials (FM) significantly impact superconductivity, enabling the emergence of spin‐triplet states and topological superconductivity. The tuning of superconductivity in SC‐FM heterostructure is also reflected in the recently discovered superconducting diode effect, characterized by nonreciprocal electric transport when time and inversion symmetries are broken. Notably, in SC‐FM systems, a time reversal operation reverses both current and magnetization, leading to the conceptualization of superconducting magnetization diode effect (SMDE). In this variant, while the current direction remains fixed, the critical currents shall be different when reversing the magnetization. Here, the existence of SMDE in SC‐FM heterostructures is demonstrated. SMDE uniquely maps magnetization states onto superconductivity by setting the read current between two critical currents for the positive and negative magnetization directions, respectively. Thus, the magnetization states can be read by measuring the superconductivity, while the writing process is accomplished by manipulating magnetization states through current‐driven spin–orbit torque to switch the superconductivity. The proposed superconducting diode magnetoresistance in SC‐FM heterostructures with an ideally infinite on/off ratio resolves the limitations of tunneling magnetoresistance in the magnetic tunneling junctions, thereby contributing to the advancement of superconducting spintronics.
Modular Design of Lipopeptide‐Based Organ‐Specific Targeting (POST) Lipid Nanoparticles for Highly Efficient RNA Delivery
Authors: Tang Chuanmei , Zhang Yexi , Li Bowen , Fan Xiangwei , Wang Zixuan , Su Rongxin , Qi Wei , Wang Yuefei 
Published: February 2025

AbstractLipid nanoparticles (LNPs) with highly efficient and specific extrahepatic targeting abilities are promising in gene delivery, and the lipopeptides (LPs) with excellent designability and functionality are expected to empower the construction of functional LNPs. This study aims to develop highly efficient ionizable components that accurately match different targeting lipid systems through the modular design of LPs. Based on this, a lipopeptide‐based organ‐specific targeting (POST) LNP screening strategy is constructed, in which lysine‐histidine‐based lipopeptides (KH‐LPs) are designed as highly efficient ionizable components. The optimal KH‐LP LNP screened in vitro shows excellent siRNA/mRNA transfecting ability in various hard‐to‐transfect cell lines. Compared to the classic LNPs, the POST LNPs screened in vivo achieve even higher (or at least comparable) efficiency and specificity in delivering mRNA and siRNA to the lung, liver, and spleen, respectively. The structure‐activity relationship (SAR) proves that the modular regulation of LP structures can accurately provide the optimal ionizable components for different targeting lipid systems, demonstrating the potential of this strategy in developing efficient and selective targeting systems, which is expected to open up more possibilities for gene therapy.
High‐Resolution and Surface‐Sensitive Tip‐Enhanced Raman Spectroscopy Characterization of Strained‐Silicon Devices through Cleanroom‐Compatible Plasmonic Probes
Authors: Mancini Chiara , Proietti Anacleto , La Penna Giancarlo , Buccini Luca , Passeri Daniele , Gambacorti Narciso , Rossi Marco 
Published: February 2025

AbstractReliable characterization techniques that guarantee real‐time quality control with a non‐destructive and multiscale approach are currently an essential necessity for electronic industries. Tip‐Enhanced Raman Spectroscopy (TERS) offers an excellent solution to this demand. In addition to providing chemical composition through the Raman spectrometer, TERS leverages the high lateral resolution of the coupled Atomic Force Microscope, enabling chemical and morphological characterization of samples down to the nanometer scale. This study advances the application of TERS by employing ad‐hoc prepared TiN‐coated probes, engineered to operate in cleanrooms while guaranteeing remarkable performances in terms of electromagnetic field enhancement. The subject of this analysis is a strained‐silicon‐based device, a technology meant to enhance the carrier's mobility in Complementary Metal‐Oxide‐Semiconductor (CMOS) architectures. The goal of the characterization is to detect the strain induced by a thin Si1‐xGex alloy grown on a Si(100) substrate in the silicon lattice. TERS enables not only the detection of strain in the crystal structure but also its magnitude at different levels of depth, despite the penetration depth of the laser employed. This study is a result of the activities carried out in the framework of the European Union founded project CHALLENGES included in the Horizon2020 program.
Functional Polymer Nanocomposites by Gas Aggregation Cluster Source and Initiated Chemical Vapor Deposition
Authors: Hartig Torge , Paulsen Joschka , Drewes Jonas , Mohamed Asmaa T. , Fattah Nasra F. Abdel , Hinrichs Cedric , Pohl Felix , Rehders Stefan , Aliyeva Ainura , Wieker Henning , Wiltfang Jörg , Veziroglu Salih , Loutfy Samah A , Aktas Oral Cenk , Vahl Alexander , Strunskus Thomas , Gülses Aydin , Amin Amal , Schröder Stefan , Faupel Franz 
Published: February 2025

AbstractFunctional metal‐polymer nanocomposites are required for highly tailored surface properties and coatings. However, past approaches like cosputtering, physical evaporation, or plasma polymerization can not retain the functionality of the polymer matrix or produce tailored nanoparticles. A new kind of codeposition of nanocomposite polymer thin films is presented via the combination of a gas aggregation cluster source (GAS) and initiated chemical vapor deposition (iCVD) in a common GAS+iCVD vacuum system. iCVD delivers ultraprecise and defect‐free polymer thin films on the nanoscale while a GAS creates nanoparticles that form in the gas phase and can be tuned in size and composition. Using the GAS+iCVD system, nanocomposites of well‐defined Ag nanoparticles in a chemically intact PTFE polymer thin film are prepared. The deposited nanocomposite proved applicable in antibacterial applications by decreasing the colony‐forming units of Enterococcus faecalis by 38%. Antiviral SARS‐CoV‐2 Spike‐ACE‐2 binding inhibition reaches 65% of pure silver nanoparticles. The nanocomposite improves the apoptotic gene expression for liver cancer cells compared to pure thin films. This new kind of codeposition paves the way for the fabrication of functional nanocomposite thin films combining the advantages of the iCVD polymer palette with a large variety of nanoparticles that can be prepared by GAS.
Jun Porcelain‐Like Birefringent Supramolecular Film for Multiple Logic Data Storage
Authors: Wu Tongyue , Liao Peilong , Qi Jinwan , Gao Shuitao , Gu Ting , Huang Jianbin , Yan Yun 
Published: February 2025

AbstractInformation security is of predominant significance, while multiple logic information encryption techniques remain challenging. Here it is reported that upon coupling the unduplicable Jun Porcelain‐like birefringence and it enables polarized fluorescence with solid phase molecular self‐assembly(SPMSA), multiple logic information encryption can be achieved upon correctly applying UV light and polarizing angles. Since each birefringence is unique and can be transformed into a corresponding digital bar code, the multiple logic can be further encrypted with the assistance of a digital bar code bank, thus yielding the ultimate information security.
Vapor‐Phase Deposited High‐Performance Uncooled PbS Short‐Wave Infrared Photodetectors and Their Sensitization Dynamics
Authors: Zhang Xingchen , Ouyang Jun , Ran Xi , Lan Xinzheng 
Published: February 2025

AbstractInfrared photodetectors based on polycrystalline PbS are very attractive in light of their low cost, high performance, and high‐temperature operation. However, the photoactive layers are often based on chemical bath deposition that limits their mass production. Meanwhile, the photosensitization dynamics are yet not fully understood. Here, high‐performance PbS photodetectors based on sputtering deposition and a study of the sensitization dynamics in a two‐step sensitization process based on oxidation and iodination are reported. The oxidation inhibits the subsequent iodination, which changes the iodination from diffusion control to surface reaction control and by extension favors the complete iodination of the whole PbS films in an optimized sensitization process. The iodination improved carrier lifetime by a combination of defection passivation, doping tuning, and the formation of a charge separation structure. The resultant PbS photodetectors show a specific detectivity ≈7.7 × 1010 Jones at a cutoff wavelength of 2.7 µm, on par with conventional uncooled PbS photodetectors. The application of PbS photodetectors in infrared imaging is finally successfully demonstrated. The development of vapor‐phase deposition and the deepened understanding of sensitization mechanism favor the application of high‐performance lead chalcogenide infrared photodetectors.
Self‐Sacrificial Template‐Induced Fabrication of Sustainable Diode‐Type Micro‐Junction toward Supercapacitors and Green H2 Evolution
Authors: Mohanty Upali Aparajita , Mohanty Ritik , Parida Kulamani 
Published: February 2025

AbstractEnergy conversion and storage are the key challenges in green chemistry that have garnered significant attention in recent decades. Heterostructure materials, with their unique interfaces, robust architectures, and synergistic effects, show great promise in enhancing energy conversion and storage capabilities. However, the intricate relationship between their structural properties and performance requires further investigation. This study introduces a novel diode‐type interfacial micro‐junction fabricated from FeCo‐based layered double hydroxide (LDH) using a self‐sacrificial template‐induced method. The micro‐junction structure significantly enhances the material's electronic properties, enabling efficient charge separation and ion transport. As a result, the material demonstrates remarkable performance in both photocatalytic hydrogen evolution and supercapacitor applications. Specifically, the optimized material exhibits superior specific capacitance (1814.14 F g−1 at 1 A g−1), high energy density (61.6 Wh kg−1), and excellent cycling stability (90.7% capacitance retention after 15 000 cycles) in coin cell supercapacitors. Additionally, the material's unique light‐harvesting capabilities and enhanced charge‐carrier dynamics make it a promising candidate for photocatalytic H2 evolution at a rate of 577.8 µmol h−1. This work not only advances the development of multifunctional materials for clean energy applications, but also opens new avenues for the design of high‐performance energy storage and conversion technologies.
Enabling Highly Recoverable and Efficient Nanosized Photocatalysts via Constructing Robust Submillimetric Patchy Particles
Authors: Jiang Zhudan , Huang Jiale , Cai Jingjin , Xiang Shanglin , Cai Dongyu 
Published: February 2025

AbstractThis work reports a class of packable composite catalysts in form of submillimetric patchy particles which demonstrate an excellent recyclability. Those patchy particles are simply constructed via the hydrothermal treatment of the dense slurry of hydroxylated ultrahigh molecular weight polyethylene (UHMWPE) and carbon nitride microtubes. These large‐sized particles can be directly packed into a tea bag made of 800 mesh nylon filter cloth. This kind of porous package allows the arrival of light on the particles and meanwhile significantly benefits the recovery of the photocatalysts from polluted water. Robust adhesion of tubular carbon nitride and UHMWPE powders is established via creating synergies between van der Waals force and hydrogen bonding for maintaining high degrading ability of these patchy particles even after 30 cycles.