bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective endoscopic decompression of the orbital apex for dysthyroid optic neuropathy
Authors: Chu Eugene A. , Miller Neil R. , Lane Andrew P. 
Published: May 2009

AbstractObjectives/Hypothesis:To introduce the concept of selective endoscopic decompression of the orbital apex for dysthyroid optic neuropathy and present surgical outcomes.Study Design:Prospective case series.Methods:Consecutive patients undergoing urgent endoscopic orbital apex decompression for dysthyroid optic neuropathy were studied prospectively. Surgical indications consisted of retrobulbar optic neuropathy with radiologic evidence of apical crowding in the setting of Graves' disease. Pre‐ and postoperative parameters assessed included exophthalmometry, visual acuity, presence or absence of exposure keratitis, diplopia, an afferent papillary defect, and Ishihara color plate testing.Results:In all patients, visual acuity was improved or was stabilized by selective orbital apex decompression. Preoperative afferent papillary defects were reversed in all but one patient. Patients with decreased color vision by Ishihara color plate testing had postoperative improvement in their scores. No patients developed postoperative diplopia. An average of 3.1 mm of ocular recession was achieved.Conclusions:Selective decompression of the orbital apex spares the anteromedial and inferior orbital walls that are typically removed in a standard endoscopic orbital decompression. This focused approach successfully addresses compressive optic neuropathy, while minimizing the risk of postoperative diplopia or delayed sinus outflow obstruction. In patients with progressing dysthyroid optic neuropathy without diplopia this modified procedure should be considered. Laryngoscope, 2009
Combined use of crushed cartilage and processed fascia lata for dorsal augmentation in rhinoplasty for Asians
Authors: Jang Yong Ju , Song Hyung Min , Yoon Yeo Jun , Sykes Jonathan M. 
Published: May 2009

AbstractObjectives/Hypothesis:Autologous dorsal nasal grafts have limitations including limited tissue availability, additional surgery time, donor site morbidity, a visible graft contour, and postoperative distortions and deformities owing to displacement and warping. This report describes our experience using combined Tutoplast‐processed fascia lata (TPFL) and crushed cartilage for dorsal augmentation and contouring in rhinoplasty.Study Design:A retrospective clinical chart review.Methods:The study involved a total of 113 patients (68 male, 45 female), who underwent crushed cartilage‐TPFL grafting to the nasal dorsum. Patient satisfaction was evaluated using a questionnaire. Photographs and postoperative histories were reviewed to assess complications including graft resorption, graft infection, warping, extrusion, irregularity, and postoperative deformity.Results:Different autologous grafts were used in combination with TPFL: septal cartilage in 70 cases (61.9%), septal cartilage and ethmoid bone in 17 cases (15.0%), costal cartilage in 15 cases (13.3%), and septal and conchal cartilage in 11 cases (9.7%). Of the 101 patients who responded to the questionnaire, 85.1% were satisfied with the surgical outcome. Complications were encountered in four patients (3.5%), comprising overcorrected dorsal augmentation in two patients, graft resorption in one patient, and dorsal irregularity in one patient. Eight patients (7.1%) required revision rhinoplasty due to dissatisfaction with the nasal tip shape (n = 6), graft resorption (n = 1) and overcorrected dorsal augmentation (n = 1).Conclusions:The combined use of crushed cartilage and TPFL appears to be a useful technique for dorsal augmentation and contouring. This technique provides favorable and predictable outcomes in rhinoplasty. Laryngoscope, 2009
Effects of cathodic electrodeposition parameters of cerium oxide film on the corrosion resistance of the 2024 Al alloy
Authors: Brunelli K. , Bisaglia F. , Kovac J. , Magrini M. , Dabalà M. 
Published: May 2009

AbstractCerium oxide thin films obtained by cathodic electrodeposition on 2024 aluminium alloy have been studied. The coatings, obtained with electrochemical deposition, offer an effective corrosion protection and require a lower deposition time when compared to chemical conversion coatings. The coatings were obtained at room temperature by deposition from CeCl3/H2O2 aqueous solutions and the influence of several parameters (CeCl3 concentration, H2O2 concentration, deposition time, current intensity) on the corrosion resistance was studied. The composition, morphology and microstructure of the films have been characterized by SEM, XPS and AFM. The corrosion resistance was investigated through potentiodynamic tests in 3% NaCl solution.
Regulation of CDX2 expression in esophageal adenocarcinoma
Authors: Vaninetti Nadine , Williams Lara , Geldenhuys Laurette , Porter Geoffrey A. , Guernsey Duane L. , Casson Alan G. 
Published: May 2009

AbstractReflux of acidic gastric contents and bile acids into the lower esophagus has been identified to have a central role in esophageal malignancy and is reported to upregulate caudal‐related homologue 2 (CDX2), a regulatory gene involved in embryonic development and axial patterning of the alimentary tract. The aim of this study was to characterize the expression of CDX2 in a well‐defined series of human esophageal tissues, comprising reflux‐induced esophagitis, premalignant Barrett esophagus (BE), and primary esophageal adenocarcinoma (EADC). To explore potential molecular regulatory mechanisms, we also studied the expression of β‐catenin, SOX9, and CDX2 promoter methylation in esophageal tissues, in addition to the effect of bile acids and nitric oxide (NO) on CDX2 expression in the normal human esophageal cell line Het1A. Relative to matched normal esophageal epithelia, CDX2 was overexpressed in esophagitis (37% for RNA; cytoplasmic immunoreactivity in 48% of tissues), a high proportion (91%) of BE tissues, and in EADC (57% for RNA; cell nuclear immunopositivity in 80%). An association with β‐catenin expression was seen, but not with SOX9 or CDX2 promoter methylation. In Het1A cells, CDX2 was upregulated following exposure to bile acids and NO, alone and in combination. These results further implicate CDX2 and β‐catenin in the molecular pathogenesis of human EADC. The observed synergistic effect of NO on the efficacy of bile acid‐induction of CDX2 suggests a novel role for NO in modulating the development of the Barrett phenotype and esophageal adenocarcinogenesis. Mol. Carcinog. © 2009 Wiley‐Liss, Inc.
Restoration of shoulder abduction function by direct muscular neurotization with the phrenic nerve fascicles and nerve grafts: A case report
Authors: Sinis Nektarios , Boettcher Michael , Werdin Frank , Kraus Armin , Schaller Hans‐Eberhard 
Published: May 2009

AbstractIn this report, we describe the first case of using the partial phrenic nerve transfer and direct muscular implantation into the deltoid muscle for restoration of the shoulder function and stability. A patient suffering from the partial brachial plexus injury with absent axillary nerve underwent reconstructive surgery by an end‐to‐end nerve coaptation using two fascicles of the phrenic nerve and two autologous nerve grafts, and direct implantation of nerve grafts into the deltoid muscle. Eighteen months after the procedure, we found a functioning biceps with 90° elbow flexion against gravity and 40° shoulder abduction with satisfactory shoulder stability. Electrophysiology revealed reinnervation potentials in the deltoid and biceps muscle. This case demonstrates a satisfactory result after using transfer of the partial ipsilateral phrenic nerve in combination with muscular implantation to restore shoulder abduction and stability. We recommend the described techniques in cases without other reconstructive options. © 2009 Wiley‐Liss, Inc. Microsurgery, 2009.
Donor sites for pedicled skeletal grafts of the hand, wrist, and forearm
Authors: Dailiana Zoe H. , Malizos Konstantinos N. , Varitimidis Sokratis E. , Urbaniak James R. 
Published: May 2009

AbstractPedicled bone and periosteal grafts provide successful reconstruction of skeletal problems of the distal radius, wrist, and hand. The purpose of this study was to evaluate the available alternatives and to propose the most suitable skeletal grafts for the reconstruction of the distal radius, and the carpal and hand bones. The alternative donor sites (dorsal and palmar distal radius, and metacarpals), their pedicles, and the potential coverage area in relation to specific wrist and hand pathology were determined in the cadaveric dissections. In the clinical setting, 75 pedicled grafts were used for the treatment of scaphoid nonunions (62 cases), lunate necrosis (8 cases), reconstruction of the metacarpal defects (2 cases), and wrist fusions (3 cases). All alternatives have the advantage of a single approach that may be performed under tourniquet control, from the same team. Among the available alternatives, surgeon's familiarity plays the most important role for the final selection of the graft. © 2009 Wiley‐Liss, Inc. Microsurgery, 2009.
Unilateral diaphragmatic paralysis and segmental motor paresis following herpes zoster
Authors: Bahadir Cengiz , Kalpakcioglu Ayşe Banu , Kurtulus Duygu 
Published: May 2009

AbstractWe report the case of a 73‐year‐old woman who complained of acute onset of pain and weakness of her left shoulder and proximal arm muscles 3 weeks after a diagnosis of herpes zoster. Electromyography revealed involvement of the C5–6 myotomes and the upper trunk of the brachial plexus. Chest X‐ray and electromyographic studies documented paralysis of the left diaphragm. One year after onset, muscle strength returned to normal, but radiographic and electrophysiologic findings of diaphragm paralysis were unchanged. Muscle Nerve 38: 1070–1073, 2008
Scheduling and power control for MAC layer design in multihop IR‐UWB networks
Authors: Pilakkat Reena , Jacob Lillykutty 
Published: May 2009

AbstractRecently, a number of researchers have proposed media access control (MAC) designs for ultra‐wideband (UWB) networks. Among them, designs based on scheduling and power control seem to be of great promise, particularly for quality‐of‐service (QoS) traffic. We investigate the efficiencies of many different choices for scheduling and power allocation for QoS traffic in a multihop impulse radio (IR)‐UWB network, with the objective of achieving both high spectral efficiency and low transmission power. Specifically, we compare different scheduling schemes employing a protocol interference‐based contention graph as well as a physical interference‐based contention graph. We propose a relative distance to determine adjacency in the protocol interference‐based contention graph. Using our improved protocol interference model with graph‐based scheduling, we obtained better performance than the physical interference‐based approach employing link‐by‐link scheduling. Copyright © 2009 John Wiley & Sons, Ltd.
Unveiling the underlying relationships over a network for monitoring purposes
Authors: Dechouniotis Dimitrios , Leontiou Nikolaos , Dimitropoulos Xenofontas , Kind Andreas , Denazis Spyros 
Published: May 2009

AbstractNowadays traffic monitoring and analysis tools provide poor information about traffic volume without giving any clear view of what the hidden rules and relationships that govern these flows are. Since the majority of flows is generated by services (web browsing, email, p2p) and most of these applications are dependent on many network assets (servers and databases) we should discover the underlying relationships of every application. We present a technique that discovers the hidden relationships among components of a network that consist of parts of specific applications. From time information and flow attributes, such as IP addresses and service ports, our method using a novel hybrid genetic algorithm produces a small set of fuzzy rules that can reveal the underlying relationships over a network without any guidance. These dependencies build a service graph which can become a useful tool for fault localization, monitoring service performance, designing changes and anomaly detection. Copyright © 2009 John Wiley & Sons, Ltd.
Characterization of the accuracy of the fast multipole method in particle simulations
Authors: Cruz Felipe A. , Barba L. A. 
Published: May 2009

AbstractThe fast multipole method (FMM) is a fast summation algorithm capable of accelerating pairwise interaction calculations, known as N‐body problems, from an algorithmic complexity of 𝒪(N2) to 𝒪(N) for N particles. The algorithm has brought a dramatic increase in the capability of particle simulations in many application areas, such as electrostatics, particle formulations of fluid mechanics, and others. Although the literature on the subject provides theoretical error bounds for the FMM approximation, there are not many reports on the measured errors in a suite of computational experiments that characterize the accuracy of the method in relation with the different parameters available to the user. We have performed such an experimental investigation, and summarized the results of about 1500 calculations using the FMM algorithm, applied to the 2D vortex particle method. In addition to the more standard diagnostic of the maximum error, we supply illustrations of the spatial distribution of the errors, offering visual evidence of all the contributing factors to the overall approximation accuracy: multipole expansion, local expansion, hierarchical spatial decomposition (interaction lists, local domain, far domain). This presentation is a contribution to any researcher wishing to incorporate the FMM acceleration to their application code, as it aids in understanding where accuracy is gained or compromised. Copyright © 2009 John Wiley & Sons, Ltd.
Initial testing of aplidin by the pediatric pre‐clinical testing program
Authors: Morton Christopher L. , Houghton Peter J. , Gorlick Richard , Kolb E. Anders , Lock Richard , Carol Hernan , Keir Stephen T. , Reynolds C. Patrick , Kang Min H. , Maris John M. , Billups Catherine , Smith Malcolm A. 
Published: May 2009

AbstractAplidin was tested in vitro at concentrations ranging from from 0.1 nM to 1.0 µM and in vivo at a dose of 0.6 mg/kg administered intraperitoneally on an every 4 days × 3‐schedule that was repeated at day 21. In vitro, Aplidin was most active against acute lymphoblastic leukemia (ALL) cell lines. In vivo, Aplidin induced significant differences in EFS distribution in 12 of 28 (43%) solid tumor models and 2 of 6 evaluable ALL models. Aplidin showed potent in vitro activity and induced significant in vivo tumor growth inhibition in some xenografts, but did not induce tumor regressions. Pediatr Blood Cancer 2009;53:509–512. © 2009 Wiley‐Liss, Inc.
Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program
Authors: Keshelava Nino , Houghton Peter J. , Morton Christopher L. , Lock Richard B. , Carol Hernan , Keir Stephen T. , Maris John M. , Reynolds C. Patrick , Gorlick Richard , Kolb E. Anders , Wu Jianrong , Smith Malcolm A. 
Published: May 2009

AbstractVorinostat, a histone deacetylase inhibitor, was evaluated against the in vitro and in vivo childhood solid tumor and leukemia models in the Pediatric Preclinical Testing Program (PPTP). In vitro testing was performed by the DIMSCAN cytotoxicity assay. In vivo, vorinostat was administered intraperitoneally to mice bearing xenografts. Vorinostat demonstrated 2‐log cell growth inhibitory activity in vitro, but generally at concentrations not sustainable in the clinic. No objective responses were observed for any of the solid tumor or acute lymphoblastic leukemia xenografts. Preclinical studies with appropriate drug combinations may provide direction for further clinical evaluations of vorinostat against selected pediatric cancers. Pediatr Blood Cancer 2009;53:505–508. © 2009 Wiley‐Liss, Inc.
A novel mutation in a family with DNA ligase IV deficiency syndrome
Authors: Unal Sule , Cerosaletti Karen , Uckan‐Cetinkaya Duygu , Cetin Mualla , Gumruk Fatma 
Published: May 2009

AbstractDNA ligase IV deficiency syndrome (LIG4 syndrome) is a rare autosomal recessive disorder characterized by microcephaly, growth retardation, low birth weight, dysmorphic facial findings, immunodeficiency, pancytopenia, and radiosensitivity due to impaired repair of DNA double‐strand breaks by non‐homologous end‐joining. Herein, we report two siblings with LIG4 syndrome with a novel mutation. One of the siblings, who had normocellular marrow, had autologous reconstitution after initial non‐myeloablative conditioning and underwent successful second hematopoietic stem cell transplantation after conditioning with busulfan, cyclophosphamide, and anti‐thymocyte globulin. Our findings indicate that transplantation with myeloablative conditioning can be used successfully in LIG4 syndrome patients. Pediatr Blood Cancer 2009;53:482–484. © 2009 Wiley‐Liss, Inc.
Simultaneous acute splenic sequestration and transient aplastic crisis in children with sickle cell disease
Authors: Yates Amber Mayfield , Hankins Jane S. , Mortier Nicole A. , Aygun Banu , Ware Russell E. 
Published: May 2009

AbstractAcute splenic sequestration crisis (ASSC) is a hematological emergency in young children with sickle cell disease (SCD), characterized by worsening anemia and splenomegaly, usually with reticulocytosis and thrombocytopenia. Transient aplastic crisis (TAC) due to parvovirus B19 infection occurs in older children with SCD, and typically manifests as worsening anemia with reticulocytopenia and no splenomegaly. Five older children with SCD (4 HbSC, 1 HbSS on hydroxyurea) developed ASSC concurrent with TAC and had a severe clinical course. Our cases suggest that older children with SCD and acute parvovirus infection should be monitored closely for splenomegaly and multi‐system dysfunction. Pediatr Blood Cancer 2009;53:479–481. © 2009 Wiley‐Liss, Inc.
Level of activity in children undergoing cancer treatment
Authors: Winter Corinna , Müller Carsten , Brandes Mirko , Brinkmann Anja , Hoffmann Christiane , Hardes Jendrik , Gosheger Georg , Boos Joachim , Rosenbaum Dieter 
Published: May 2009

AbstractBackgroundThe diagnosis of cancer bears severe implications for pediatric patients. One immense restriction consists in a reduced level of activity due to different factors. Physical activity affects various aspects of development and can be regarded as an essential part of a child's life. In the present study physical activity in patients undergoing cancer therapy was quantified in order to determine the extent of the restriction and to provide baseline information for the assessment of possible interventions.ProcedurePhysical activity in 80 patients and 45 healthy children matched for age and gender was measured using the StepWatch 3™ Activity Monitor (SAM, OrthoCare Innovations).ResultsPediatric cancer patients, at 2,787 gait cycles (gcs) per day, were significantly less active than their healthy counterparts (8,096 gcs). Patients were significantly more active at home than during inpatient stays (3,185 gcs compared to 1,830 gcs), and patients with bone tumors were less active than those with leukemia regarding both, the amount (1,849 gcs vs. 2,992 gcs) and the intensity of activity.ConclusionThe present study quantified an often observed but so far hardly assessable problem. Activity in cancer patients is considerably reduced and patients with bone tumors are at increased risk from the detrimental effects of prolonged inactivity. Both our findings and the accepted fact that activity is an essential element of child development confirm the need for interventions tailored to a patient's needs and abilities during the course of treatment. Pediatr Blood Cancer 2009;53:438–443. © 2009 Wiley‐Liss, Inc.
Ultrasound‐guided core needle biopsy for the diagnosis of rhabdomyosarcoma in childhood
Authors: Chowdhury Tanzina , Barnacle Alex , Haque Saira , Sebire Neil , Gibson Sian , Anderson John , Roebuck Derek 
Published: May 2009

AbstractBackgroundMost commonly a tissue diagnosis of rhabdomyosarcoma (RMS) in children is made by biopsy as opposed to primary resection. Open surgical procedures are often recommended to obtain sufficient material for accurate and complete diagnostic work up. Our institution has routinely used image‐guided needle biopsies for soft tissue tumour diagnosis. We therefore sought to assess diagnostic accuracy and completeness, and procedure safety of consecutive patients diagnosed by needle biopsies in a single institution.MethodsA retrospective review of consecutive biopsies of patients who were diagnosed with RMS or undifferentiated sarcoma in a single institution over a 9‐year period.ResultsThere were 24 children diagnosed with RMS or undifferentiated sarcoma who underwent 37 procedures (30 primary site and 7 draining lymph nodes). In the primary site diagnostic procedures, definitive diagnosis was made in all cases. In the majority of cases there was sufficient material for molecular analysis, cytogenetics and freezing. There were no complications of biopsy.ConclusionsIn the hands of experienced operators, image‐guided needle biopsies of RMSs allow for accurate diagnosis, allow sufficient material to be obtained for supplementary studies and research, and are associated with minimal morbidity. Pediatr Blood Cancer 2009;53:356–360. © 2009 Wiley‐Liss, Inc.
Cytomegalovirus infection in children undergoing hematopoietic stem cell transplantation in Chile
Authors: Paris Claudia , Kopp Katherine , King Alejandra , Santolaya Maria E. , Zepeda Ana J. , Palma Julia 
Published: May 2009

AbstractBackgroundCytomegalovirus (CMV) infection remains as an important cause of morbidity and mortality in children undergoing hematopoietic stem cell transplantation (HSCT). Our aim was to assess the incidence, risk factors, and outcome related to CMV infection in children after HSCT in a developing country.MethodsFrom October 1, 1999, to December 31, 2005, we prospectively studied all patients admitted to the HSCT unit at Hospital Luis Calvo Mackenna in Santiago, Chile. Serologic studies before transplantation and weekly CMV infection surveillance (antigenemia or quantitative PCR) were routinely obtained. Patients with positive antigenemia or quantitative PCR received pre‐emptive therapy with ganciclovir, and cases of unfavorable clinical evolution, persistent positive antigenemia, or quantitative PCR after 14 days of ganciclovir were treated with foscarnet.ResultsNinety‐seven patients received HSCT. Their median age was 8 years (range, 3 months to 24 years) and their overall survival was 67%. CMV reactivation was diagnosed in 26 patients. Of these, three developed CMV disease (two interstitial pneumonia, one hemorrhagic cystitis). One of the patients with pneumonia died. Risk factors identified were pre‐transplant serologic status (positive recipient), acute and chronic graft versus host disease (GvHD), GvHD prophylaxis, and treatment with antithymocyte globulin.ConclusionsThe rate and prognosis of CMV infection among children treated at our HSCT unit is similar to those reported from industrialized countries. These findings reflect adequate prevention and management of CMV infection within our program. Pediatr Blood Cancer 2009;53:453–458. © 2009 Wiley‐Liss, Inc.