bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Rare Case of Extensive Hydrofluoric Acid Burn
Authors: Hu Gaozhong , Shu Ziqin , Li Yuan , Song Huapei 
Published: June 2024

Abstract
Hydrofluoric acid (HF) is a strongly corrosive, highly toxic, and highly dangerous mineral acid. Burns with over 1% TBSA caused by anhydrous HF can lead to deep tissue damage, hypocalcemia, poisoning, and even death. In recent years, HF has become one of the most common substances causing chemical burns and ranks as the leading cause of death from chemical burns. Herein, we report a rare case with 91% TBSA burns caused by 35% HF. The patient developed complications such as shock, severe hypocalcemia, metabolic acidosis, and respiratory failure. Multidisciplinary team consultation (burns, respiratory medicine, nephrology, infectious disease, and pharmacy) was performed immediately after admission. An individualized diagnosis and treatment plan were developed for the patient. The patient was given intensive care, blood volume monitoring, tracheotomy, fluid resuscitation, continuous blood purification, anti-infective and analgesic treatments, intravenous and percutaneous calcium supplementation, early rehabilitation training, psychological rehabilitation, and other treatments. To prevent the wound from deepening, large-area debridement and skin grafting were performed early after the injury. A large dose of 10% calcium gluconate was injected into the patient in divided doses, and the wound was continuously treated with wet dressings. Multiple surgical debridements, negative pressure wound treatment, biological dressings, and Meek skin grafting were performed. After most of the wounds (approximately 85% TBSA) healed, the patient was discharged from the hospital and continued to undergo dressing changes at a local hospital. The patient was followed up 3 months after discharge. All the wounds healed well, and the patient basically regained functional independence in daily life.
Together inbreeding and reproductive compensation favor lethal t-haplotypes
Authors: Munasinghe Manisha , Brandvain Yaniv 
Published: June 2024

Abstract
Male mice who are heterozygous for distorting and non-distorting alleles at the t-haplotype transmit the driving t-haplotype around 90% of the time—a drastic departure from Mendelian expectations. This selfish act comes at a cost. The mechanism underlying transmission distortion in this system causes severe sterility in males homozygous for the drive alleles, ultimately preventing its fixation. Curiously, many driving t-haplotypes also induce embryonic lethality in both sexes when homozygous; however, this is neither universal nor a necessity for this distortion mechanism. Charlesworth provided an adaptive explanation for the evolution of lethal t-haplotypes in a population segregating for distorting and non-distorting t alleles—if mothers compensate by replacing dead embryos with new offspring (or by transferring energy to surviving offspring), a recessive lethal can be favored because it effectively allows mothers the opportunity to trade in infertile males for potentially fertile offspring. This model, however, requires near complete reproductive compensation for the invasion of the lethal t-haplotype and produces an equilibrium frequency of lethal drivers well below what is observed in nature. We show that low levels of systemic inbreeding, which we model as brother–sister mating, allow lethal t-haplotypes to invade with much lower levels of reproductive compensation. Furthermore, inbreeding allows these lethal haplotypes to largely displace the ancestral male-sterile haplotypes. Our results show that together inbreeding and reproductive compensation move expected equilibria closer to observed haplotype frequencies in natural populations and occur under lower, potentially more reasonable, parameters.
High seed losses in mountain birch (Betula pubescens ssp. tortuosa) and developmental, ecological, and environmental correlates
Authors: Óskarsdóttir Guðrún , Thórhallsdóttir Thóra E , Svavarsdóttir Kristín 
Published: June 2024

Abstract
Plants typically experience great losses from their reproductive potential represented by ovule production to the post-dispersal crop of viable seed. We examined seed density and viability in a founder population of mountain birch (Betula pubescens ssp. tortuosa), aiming to quantify losses at different stages and examine potential selection forces on the reproduction success of the founder generation of an isolated population. At the time of the study (2017–2020), the population had recently reached reproductive maturity, following its colonization around 1990 through long-distance dispersal onto an early successional outwash plain in southeast Iceland. Seed densities were high, but 89% of apparently intact seeds did not contain an embryo, despite being visually indistinguishable from filled seeds. Externally evident losses amounted to about 45% of the total seed crop and were mostly due to predation by the gall midge Semudobia betulae. When all losses were accounted for, 2.7% of the seed crop remained viable and germinated. Pollen limitation may partially explain the high incidence of empty seeds. Excessive flower production is compatible with the predator satiation hypothesis but cannot explain pre-dispersal losses. Another adaptation to predation, masting, appears poorly developed in Iceland. Our results suggest the presence of constraints on the reproduction potential of the new island population, that are more limiting than in neighbouring populations, and we discuss their developmental, ecological, and environmental correlates.
Climate refugia along Lake Superior’s shores: disjunct arctic–alpine plants rely on cool shoreline temperatures but are restricted to highly exposed habitat under climate warming
Authors: Hillman Ashley , Nielsen Scott E 
Published: June 2024

Abstract
Climate refugia can serve as a remnant habitat or stepping stones for species dispersal under climate warming. The largest freshwater lake by surface area, Lake Superior, USA and Canada, serves as a model system for understanding cooling-mediated local refugia, as its cool water temperatures and wave action have maintained shoreline habitats suitable for southern disjunct populations of arctic–alpine plants since deglaciation. Here, we seek to explain spatial patterns and environmental drivers of arctic–alpine plant refugia along Lake Superior’s shores, and assess future risk to refugia under moderate (+3.5 °C) and warmest (+5.7 °C) climate warming scenarios. First, we examined how the interactive effects of summer surface water temperatures and wind affected onshore temperatures, resulting in areas of cooler refugia. Second, we developed an ecological niche model for the presence of disjunct arctic–alpine refugia (pooling 1253 occurrences from 58 species) along the lake’s shoreline. Third, we fit species distribution models for 20 of the most common arctic–alpine disjunct species and predicted presence to identify refugia hotspots. Finally, we used the two climate warming scenarios to predict changes in the presence of refugia and disjunct hotspots. Bedrock type, elevation above water, inland distance, July land surface temperature from MODIS/Terra satellite and near-shore depth of water were the best predictors of disjunct occurrences. Overall, we predicted 2236 km of the shoreline (51%) as disjunct refugia habitat for at least one species under current conditions, but this was reduced to 20% and 7% with moderate (894 km) and warmest (313 km) climate change projections.
Catch me if you can: signal localization with knockoff e-values
Authors: Gablenz Paula , Sabatti Chiara 
Published: June 2024

Abstract
We consider problems where many, somewhat redundant, hypotheses are tested and we are interested in reporting the most precise rejections, with false discovery rate (FDR) control. This is the case, for example, when researchers are interested both in individual hypotheses as well as group hypotheses corresponding to intersections of sets of the original hypotheses, at several resolution levels. A concrete application is in genome-wide association studies, where, depending on the signal strengths, it might be possible to resolve the influence of individual genetic variants on a phenotype with greater or lower precision. To adapt to the unknown signal strength, analyses are conducted at multiple resolutions and researchers are most interested in the more precise discoveries. Assuring FDR control on the reported findings with these adaptive searches is, however, often impossible. To design a multiple comparison procedure that allows for an adaptive choice of resolution with FDR control, we leverage e-values and linear programming. We adapt this approach to problems where knockoffs and group knockoffs have been successfully applied to test conditional independence hypotheses. We demonstrate its efficacy by analysing data from the UK Biobank.
Relationship between the frequency and duration of masturbation and the sexual health literacy and sexual function of women in western Turkey: a cross-sectional study
Authors: Karaahmet Aysu Yıldız , Bilgiç Fatma Şule 
Published: June 2024

Abstract

Background
Although sexual life and its knowledge are still taboo in many cultures, especially for women, it can negatively affect women’s sexual health.

Aim
The aim of this study was to examine the relationship between the frequency and duration of masturbation and the sexual health literacy among young Muslim women of reproductive age between 18 and 25 years living in western Turkey.

Methods
The cross-sectional descriptive study was conducted with 921 young women in western Turkey between March and December 2023. Participants were included in the study per the snowball method. The data consisted of attitudes, beliefs, and behaviors regarding masturbation, sexual life, and sexual health literacy. Data were obtained on an online platform and analyzed with SPSS (version 24; IBM). Difference, correlation, and regression analyses were performed. The significance level for statistical analyses was accepted as P &lt; .05.

Outcomes
The outcomes of the study are the attitudes, beliefs, and behaviors regarding masturbation, orgasm, sexual health literacy, and sexual function in women.

Results
The participants were young Muslim women aged 21.00 ± 1.89 years (mean ± SD). The frequency of masturbation was 5.06 ± 2.03 times per month, and the duration was 3.47 ± 1.77 minutes per day. Masturbation frequency and duration were significantly associated with sexual health literacy and sexual function (P &lt; .001). According to regression analysis, sexual function increased and sexual health literacy increased as masturbation frequency and duration increased (P &lt; .001).

Clinical Implications
This study presents results on the current situation regarding the sexual health literacy and sexual lives in women from different geographies and cultures, and it serves as a source for future studies on areas that need to be improved.

Strengths and Limitations
The limitation of the study is that it was conducted only with Muslim and Turkish women who use smartphones and are sexually active, so it cannot be generalized to all women. The strengths of the study are that it was conducted with a sample of 921 women, it was based on self-report and addressed many dimensions related to masturbation and female sexuality, and the results were reached through exploratory analysis.

Conclusion
The study found that the higher the duration and frequency of masturbation in young women, the better their sexual function and higher their sexual literacy.
Detecting galaxy tidal features using self-supervised representation learning
Authors: Desmons Alice , Brough Sarah , Lanusse Francois 
Published: June 2024

ABSTRACT
Low surface brightness substructures around galaxies, known as tidal features, are a valuable tool in the detection of past or ongoing galaxy mergers, and their properties can answer questions about the progenitor galaxies involved in the interactions. The assembly of current tidal feature samples is primarily achieved using visual classification, making it difficult to construct large samples and draw accurate and statistically robust conclusions about the galaxy evolution process. With upcoming large optical imaging surveys such as the Vera C. Rubin Observatory’s Legacy Survey of Space and Time, predicted to observe billions of galaxies, it is imperative that we refine our methods of detecting and classifying samples of merging galaxies. This paper presents promising results from a self-supervised machine learning model, trained on data from the Ultradeep layer of the Hyper Suprime-Cam Subaru Strategic Program optical imaging survey, designed to automate the detection of tidal features. We find that self-supervised models are capable of detecting tidal features, and that our model outperforms previous automated tidal feature detection methods, including a fully supervised model. An earlier method applied to real galaxy images achieved 76 per cent completeness for 22 per cent contamination, while our model achieves considerably higher (96 per cent) completeness for the same level of contamination. We emphasize a number of advantages of self-supervised models over fully supervised models including maintaining excellent performance when using only 50 labelled examples for training, and the ability to perform similarity searches using a single example of a galaxy with tidal features.
Widespread AGN feedback in a forming brightest cluster galaxy at z = 4.1, unveiled by JWST
Authors: Saxena Aayush , Overzier Roderik A , Villar-Martín Montserrat , Heckman Tim , Roy Namrata , Duncan Kenneth J , Röttgering Huub , Miley George , Aydar Catarina , Best Philip , Bosman Sarah E I , Cameron Alex J , Gabányi Krisztina Éva , Humphrey Andrew , Morais Sandy , Onoue Masafusa , Pentericci Laura , Reynaldi Victoria , Venemans Bram 
Published: June 2024

ABSTRACT
We present rest-frame optical JWST Near-infrared Spectrograph (NIRSpec) integral field unit (IFU) spectroscopy of TN J1338−1942 at z = 4.1, one of the most luminous galaxies in the early universe with powerful extended radio jets. Previous observations showed evidence for strong, large-scale outflows based on its large (∼150 kpc) halo detected in Ly α, and high-velocity [O ii] emission features detected in ground-based spectroscopy. Our NIRSpec/IFU observations spatially resolve the emission line properties across the host galaxy. We find at least five concentrations of strong line emission, coinciding with discrete continuum features previously detected in imaging from Hubble Space Telescope and JWST, over an extent of ∼2 arcsec (∼15 kpc). The spectral diagnostics unambiguously trace active galactic nuclei (AGN) activity plus interaction between the interstellar medium and the radio jet as the dominant mechanisms for the ionization state and kinematics of the gas in the system. A secondary region of very high ionization lies at roughly 5 kpc away from the nucleus, and within the context of an expanding cocoon enveloping the radio lobe, this may be explained by strong shock-ionization of the entrained gas. However, it could also signal the presence of a second obscured AGN, which may offer an explanation for an intriguing outflow feature seen perpendicular to the radio axis. The presence of a dual supermassive black holes system in this galaxy would support that large galaxies in the early Universe quickly accumulated their mass through the merging of smaller units, at the centres of large overdensities. The inferred black hole mass to stellar mass ratio of 0.01−0.1 for TNJ1338 points to a more rapid assembly of black holes compared to the stellar mass of galaxies at high redshifts, consistent with other recent observations.
Replication protein A dynamically re-organizes on primer/template junctions to permit DNA polymerase δ holoenzyme assembly and initiation of DNA synthesis
Authors: Norris Jessica L , Rogers Lindsey O , Pytko Kara G , Dannenberg Rachel L , Perreault Samuel , Kaushik Vikas , Kuppa Sahiti , Antony Edwin , Hedglin Mark 
Published: June 2024

Abstract
DNA polymerase δ (pol δ) holoenzymes, comprised of pol δ and the processivity sliding clamp, PCNA, carry out DNA synthesis during lagging strand replication, initiation of leading strand replication, and the major DNA damage repair and tolerance pathways. Pol δ holoenzymes are assembled at primer/template (P/T) junctions and initiate DNA synthesis in a stepwise process involving the major single strand DNA (ssDNA)-binding protein complex, RPA, the processivity sliding clamp loader, RFC, PCNA and pol δ. During this process, the interactions of RPA, RFC and pol δ with a P/T junction all significantly overlap. A burning issue that has yet to be resolved is how these overlapping interactions are accommodated during this process. To address this, we design and utilize novel, ensemble FRET assays that continuously monitor the interactions of RPA, RFC, PCNA and pol δ with DNA as pol δ holoenzymes are assembled and initiate DNA synthesis. Results from the present study reveal that RPA remains engaged with P/T junctions throughout this process and the RPA•DNA complexes dynamically re-organize to allow successive binding of RFC and pol δ. These results have broad implications as they highlight and distinguish the functional consequences of dynamic RPA•DNA interactions in RPA-dependent DNA metabolic processes.
Plectic Jacobians
Authors: Fornea Michele 
Published: June 2024

ABSTRACT
Looking for a geometric framework to study plectic Heegner points, we define a collection of abelian varieties – called plectic Jacobians—using the middle-degree cohomology of quaternionic Shimura varieties (QSVs). The construction is inspired by the definition of Griffiths’ intermediate Jacobians and rests on Nekovář–Scholl’s notion of plectic Hodge structures. Moreover, we construct exotic Abel–Jacobi maps sending certain zero cycles on QSVs to plectic Jacobians.
Aligning antimicrobial resistance surveillance with schistosomiasis research: an interlinked One Health approach
Authors: O'Ferrall Angus M , Musaya Janelisa , Stothard J Russell , Roberts Adam P 
Published: June 2024

Abstract
One Health surveillance involves the analysis of human, animal and environmental samples, recognising their interconnectedness in health systems. Such considerations are crucial to investigate the transmission of many pathogens, including drug-resistant bacteria and parasites. The highest rates of antimicrobial resistance (AMR)-associated deaths are observed in sub-Saharan Africa, where concurrently the waterborne parasitic disease schistosomiasis can be highly endemic in both humans and animals. Although there is growing acknowledgment of significant interactions between bacteria and parasites, knowledge of relationships between schistosomes, microbes and AMR remains inadequate. In addition, newly emergent research has revealed the previously underappreciated roles of animals and the environment in both AMR and schistosomiasis transmission. We consider shared environmental drivers and colonisation linkage in this narrative review, with a focus on extended-spectrum beta-lactamase-mediated resistance among bacteria from the Enterobacteriaceae family, which is exceedingly prevalent and responsible for a high burden of AMR-associated deaths. Then we examine novel findings from Malawi, where the landscapes of AMR and schistosomiasis are rapidly evolving, and make comparisons to other geographic areas with similar co-infection epidemiology. We identify several knowledge gaps that could be addressed in future research, including the need to characterise the impact of intestinal schistosomiasis and freshwater contact on intestinal AMR colonisation, before proposing a rationale for connecting AMR surveillance and schistosomiasis research within a One Health framework.
Long-term intravenous devices: a narrative review of their placement
Authors: Roche Sabine 
Published: June 2024

Purpose of review
This review summarizes the latest findings and recommendations about the characteristics, indications and use of peripheral and central long-term venous access devices.
The various complications inherent in these devices are becoming better known, and their contributing factors determined, which could make it possible to reduce their incidence.

Recent findings
Some measures are integrated into recommendations for good practice, such as appropriate selection of devices, the preferential use of the thinnest catheters, and cyanoacrylate glue and dressings impregnated with chlorhexidine.

Summary
Improving understanding of the phenomena leading to infectious and thrombotic complications, as well as better knowing the differences between intravenous devices and their respective indications, should lead to improvement of in-hospital and out-of-hospital care.
Progress in the validation of nociception monitoring in guiding intraoperative analgesic therapy
Authors: Van Santvliet Hendrik , Vereecke Hugo E.M. 
Published: June 2024

Purpose of review
This article summarizes the current level of validation for several nociception monitors using a categorized validation process to facilitate the comparison of performance.

Recent findings
Nociception monitors improve the detection of a shift in the nociception and antinociception balance during anesthesia, guiding perioperative analgesic therapy. A clear overview and comparison of the validation process for these monitors is missing.

Results
Within a 2-year time-frame, we identified validation studies for four monitors [analgesia nociception index (ANI), nociception level monitor (NOL), surgical pleth index (SPI), and pupillometry]. We categorized these studies in one out of six mandatory validation steps: developmental studies, clinical validation studies, pharmacological validation studies, clinical utility studies, outcome improvement studies and economical evaluation studies. The current level of validation for most monitors is mainly focused on the first three categories, whereas ANI, NOL, and SPI advanced most in the availability of clinical utility studies and provide confirmation of a clinical outcome improvement. Analysis of economical value for public health effects is not yet publicly available for the studied monitors.

Summary
This review proposes a stepwise structure for validation of new monitoring technology, which facilitates comparison between the level of validation of different devices and identifies the need for future research questions.
Environmental impact of anesthetic drugs
Authors: Gordon Diane W. 
Published: June 2024

Purpose of review
The environmental impact of anesthesia far exceeds that of other medical specialties due to our use of inhaled anesthetic agents (which are potent greenhouse gases) and many intravenous medications.

Recent findings
Calls for reducing the carbon footprint of anesthesia are ubiquitous in the anesthesia societies of developed nations and are appearing in proposed changes for hospital accreditation and funding in the United States. The body of research on atmospheric, land and water impacts of anesthetic pharmaceuticals is growing and generally reinforces existing recommendations to reduce the greenhouse gas emissions of anesthesia care.

Summary
The environmental impact of anesthesia care should factor into our clinical decisions. The onus is on clinicians to safely care for our patients in ways that contribute the least harm to the environment. Intravenous anesthesia and regional techniques have less environmental impact than the use of inhaled agents; efforts to reduce and properly dispose of pharmaceutical waste are central to reducing environmental burden; desflurane should not be used; nitrous oxide should be avoided except where clinically necessary; central nitrous pipelines should be abandoned; low fresh gas flows should be utilized whenever inhaled agents are used.