bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual initial presentation of prostate adenocarcinoma with inguinal lymph nodes metastases: a case report
Authors: Glavinov Maja Sofronievska , Jovanovic Rubens , Majstorov Venjamin , Burneski Jovo , Nikolovski Andrej 
Published: April 2024

Abstract
The presence of lymph node metastases in prostate adenocarcinoma is a poor prognostic sign, and mortality rates are often high. Inguinal lymph node metastases are an unusual presentation of advanced disease, and they can be easily misinterpreted with other diseases. We present a case of a 63-year-old patient with no previous symptoms and signs of prostate disorder with a right-sided inguinal lump and abdominal pain. The CT scan showed right inguinal and retroperitoneal lymphadenopathy. Elevated PSA serum levels, digital rectal examination, and skeletal scintigraphy with 99mTc-MDP favored the diagnosis of metastatic prostate adenocarcinoma. Since the patient denied prostate biopsy, a dissection of the right inguinal nodes was performed. Histopathological findings confirmed metastatic prostate adenocarcinoma. The treatment was hormonal and bisphosphonate therapy, with objective posttreatment improvement. Based on this case, it can be concluded that inguinal and generalized lymphadenopathy are potential initial manifestations of metastatic prostate adenocarcinoma in male patients.
The role of cardiac computed tomography in diagnostic and prognostic assessment of pregnancy related spontaneous coronary artery dissection: a case report
Authors: Luciano Alessandra , Cerimele Cecilia , Mecchia Daniele , Mozzani Marcello , Steffani Simone , D’Errico Francesca , Di Donna Carlo , De Stasio Vincenzo , Garaci Francesco , Chiocchi Marcello 
Published: April 2024

Abstract
Spontaneous coronary artery dissection (SCAD) is the most common cause of myocardial infarction during pregnancy or the postpartum period and has a major impact on cardiovascular morbidity and death in pregnant women. A 38-year-old woman with sudden cardiac arrest ten days postpartum urgently underwent coronarography, which showed an intraparietal hematoma of the left anterior descending (LAD) artery. Two days later, coronary computed tomography angiography (CCTA) was performed, which showed the evidence of SCAD in the mid-distal tract of LAD and the presence of transmural ischemic infarction in the apex and mid antero-septal wall in delayed acquisition. The patient was treated with a beta-blocker. Four months later CCTA showed complete resolution of SCAD and evolution of the infarcted areas. Given the high accuracy and noninvasiveness of CCTA, our case highlights the potential role of this imaging modality in the diagnosis and follow-up of pregnancy associated SCAD.
Buschke-Lowenstein tumor in the penis and anorectal region: case report
Authors: Kabila Badr , Imrani Kaoutar , Kaddouri Soufiane , Boujida Ismail , Zouaidia Fouad , Billah Nabil Moatassim , Nassar Itimad 
Published: April 2024

Abstract
The Buschke-Lowenstein Tumor is a giant condyloma acuminatum caused by human papillomavirus, most commonly types 6 or 11. It is a rare condition with an estimated frequency of 0.1% in the general population. Transmission primarily occurs through sexual contact. It particularly affects men, predominantly appearing on the penis, characterized by its deep-seated growth, potential for degeneration, and tendency to recur after treatment. Surgery is the preferred treatment. We present the case of a50-year-old patient with a history of recurrent urethritis and multiple sexual partners. The patient sought medical attention for a swelling on the penis that had been progressively developing over the past 10 years. An MRI was performed for a locoregional study, revealing a perineal and penile mass with polylobed contours resembling a cauliflower, along with a sizable perineal mass Histological examination of a biopsy sample from the penis confirmed the diagnosis. Unfortunately, due to the tumor’s characteristics and the patient’s condition, surgery was contraindicated.
A novel cause of erythromelalgia due to pseudoephedrine
Authors: Kravvas Georgios , Aboukhatwah Nada , Ali Lana , Bray Adam P 
Published: April 2024

Abstract

Objective
Erythromelalgia is a rare, highly debilitating disorder characterised by severe episodes of discomfort, erythema, and desquamation of the extremities. Its causes include genetic factors, medications, and several underlying medical conditions. This paper describes a novel cause of erythromelalgia through a case report and literature review.

Case description
A 47-year-old Caucasian man presented with a two-year history of intermittent pain, redness and desquamation of the hands. He experienced several such episodes, each lasting 3-4 weeks. A skin biopsy confirmed the diagnosis of erythromelalgia. After several recurrences, he admitted to the intermittent use of pseudoephedrine as a nasal decongestant, which coincided with the episodes of erythromelalgia. Complete resolution of symptoms was reported on cessation of this medication.

Conclusion
Pseudoephedrine has been reported to cause a wide range of cutaneous reactions but has not been known to precipitate erythromelalgia. Recognition of this rare side effect may offer early diagnosis and reduced morbidity.
Co-infection with plasmodium falciparum and COVID-19 with lethal outcome. First clinical case from Bulgaria
Authors: Velev Valeri , Atanassova Maria , Aksentieva Yana , Ahmet Fatme Melbahtin , Yordanova Ralica , Harizanov Rumen 
Published: April 2024

Abstract
The symptoms of COVID-19 include febrility and mainly catarrhal symptoms. In severe cases, patients present with progression to lower respiratory tract and acute respiratory distress (ARDS) and multi-organ dysfunction. Malaria caused by P. falciparum is a severe, endemic parasitosis, mainly in Africa. In some cases, it can be complicated with ARDS. We present a case of a patient who returned from Nigeria with respiratory symptoms, in which both COVID-19 infection and tropical malaria were proven; with a fatal outcome.
Perception of Polish patients with cancer of the ethical and legal issues related to biobank research
Authors: Domaradzki Jan , Czekajewska Justyna , Walkowiak Dariusz 
Published: April 2024

Abstract

Background
Although biobanks have become fundamental to many research centers and contribute to medical development, they generate many ethical and legal issues that may discourage patients from donating.

Materials and Methods
To understand patients’ perception of ethical and legal issues related to biobanks we conducted a survey among 548 Polish patients with cancer.

Results
While 93.1% of patients with cancer declared themselves willing to donate biospecimens left over after a medical procedure to a biobank, most opted for one-time consent or study-specific consent, blanket consent being less frequently preferred. Many patients believed that future use of previously collected tissues require second contact. Most patients preferred pseudonymization over anonymization of the data, and supported donors’ right to withdraw informed consent at any given moment. Finally, while personal health information was the most expected form of compensation for donation, most patients suggested that all parties, including the biobank concerned, the sponsors of the research, and the donors, should own the rights to cancer tissues donated and profit from the biobank research. Patients’ opinions on the ethical and legal issues related to biobank research were associated with age, sex, religiosity, education level, and place of residence.

Conclusions
Since biobanks generate ethical and legal issues related to informed consent, data protection and storage, as well as the sharing of biosamples, tissue ownership, and profit sharing, that may discourage patients from donation, when asking a patient for a donation, healthcare professionals should communicate in a donor-centered manner and address patients’ ethical and moral concerns related to donation and offer resources to help manage these concerns.
Drought-induced circular RNAs in maize roots: Separating signal from noise
Authors: Xu Jie , Wang Qi , Tang Xin , Feng Xiaoju , Zhang Xiaoyue , Liu Tianhong , Wu Fengkai , Wang Qingjun , Feng Xuanjun , Tang Qi , Lisch Damon , Lu Yanli 
Published: April 2024

Abstract
Circular RNAs (circRNAs) play an important role in diverse biological processes; however, their origin and functions, especially in plants, remain largely unclear. Here, we used 2 maize (Zea mays) inbred lines, as well as 14 of their derivative recombination inbred lines with different drought sensitivity, to systematically characterize 8,790 circRNAs in maize roots under well-watered (WW) and water-stress (WS) conditions. We found that a diverse set of circRNAs expressed at significantly higher levels under WS. Enhanced expression of circRNAs was associated with longer flanking introns and an enrichment of long interspersed nuclear element retrotransposable elements. The epigenetic marks found at the back-splicing junctions of circRNA-producing genes were markedly different from canonical splicing, characterized by increased levels of H3K36me3/H3K4me1, as well as decreased levels of H3K9Ac/H3K27Ac. We found that genes expressing circRNAs are subject to relaxed selection. The significant enrichment of trait-associated sites along their genic regions suggested that genes giving rise to circRNAs were associated with plant survival rate under drought stress, implying that circRNAs play roles in plant drought responses. Furthermore, we found that overexpression of circMED16, one of the drought-responsive circRNAs, enhances drought tolerance in Arabidopsis (Arabidopsis thaliana). Our results provide a framework for understanding the intricate interplay of epigenetic modifications and how they contribute to the fine-tuning of circRNA expression under drought stress.
RNA editing factor SlORRM2 regulates the formation of fruit pointed tips in tomato
Authors: Yang Yongfang , Ji Yajing , Wang Keru , Li Jinyan , Zhu Guoning , Ma Liqun , Ostersetzer-Biran Oren , Zhu Benzhong , Fu Daqi , Qu Guiqin , Luo Yunbo , Zhu Hongliang 
Published: April 2024

Abstract
Domestication of tomato (Solanum lycopersicum) has led to large variation in fruit size and morphology. The development of the distal end of the fruit is a critical factor in determining its overall shape. However, the intricate mechanisms underlying distal fruit development require further exploration. This study aimed to investigate the regulatory role of an organelle RNA recognition motif (RRM)-containing protein SlORRM2 in tomato fruit morphology development. Mutant plants lacking SlORRM2 exhibited fruits with pointed tips at the distal end. However, this phenotype could be successfully restored through the implementation of a “functional complementation” strategy. Our findings suggest that the formation of pointed tips in the fruits of the CR-slorrm2 mutants is linked to alterations in the development of the ovary and style. We observed a substantial decrease in the levels of indole-3-acetic acid (IAA) and altered expression of IAA-related response genes in the ovary and style tissues of CR-slorrm2. Moreover, our data demonstrated that SlORRM2 plays a role in regulating mitochondrial RNA editing sites, particularly within genes encoding various respiratory chain subunits. Additionally, the CR-slorrm2 mutants exhibited modified organellar morphology and increased levels of reactive oxygen species. These findings provide valuable insights into the mechanisms underlying the formation of fruit pointed tips in tomato and offer genetic resources for tomato breeding.
Tissue equivalent conversion of silicon-based microdosemeters in hadron therapy
Authors: Yu Songke , Shi Hui , Zhong Xiaojuan 
Published: April 2024

Abstract
Silicon has been developed as a microdosemeter, as it can provide sensitive volumes at submicrometric levels, does not need a gas supply, has a fast response, and has low power consumption. However, since the energy response in silicon is not the same as that in tissue, a spectral conversion from silicon to tissue is necessary to obtain the probability distribution of energy deposition in tissue. In this work, we present a method for microdosimetric spectra conversion from silicon to tissue based on the scaled Fourier transformation and the geometric scaling factor, which shows relatively good results in the spectral conversion from diamond to tissue. The results illustrate that the method can convert the energy deposition spectra from silicon to tissue with proper accuracy. Meanwhile, the inconsistency between the converted and actual spectra due to the inherent difference was also observed. Whereas, the reasons for the disagreement are different. For the plateau part of the Bragg curve, the discrepancy between the converted and actual spectra is due to the poor tissue equivalent of silicon. For the proximal part of the Bragg curve, the spectral difference is attributed to the different shapes of the energy deposition spectra obtained in silicon and water, which is the same as that in the diamond. In summary, this method can be employed in the tissue equivalent conversion of silicon microdosemeter, but the poor tissue equivalent of silicon limited the accuracy of this method. In addition, the correction for the deviation between the converted and calculated spectra due to the difference in spectral shapes is required to improve the practicality of this mod.
“It’s Complicated”: How Black and White Women Innovate with Situationships at Midlife
Authors: Armstrong Elizabeth A , Hamilton Laura T , Garrison Spencer A , Giles Kelly N , Hoffman Charity M , Perone Angela K 
Published: April 2024

Abstract
The sexual and romantic activities of unmarried women at midlife are often invisible in survey research based on normative categories of adult intimacy. However, women at this stage in the life course are structurally positioned to innovate with intimacy. In our interviews with 53 Black and white women between ages 33-58, outside of stable partnerships, and open to sex and intimacy with men, we find that women’s frustration with marriage and marriage-like commitment, negative experiences dating, and lack of interest in celibacy led them to experiment with a new form of intimacy. A majority engaged in ongoing liaisons in a liminal space between casual and committed—what emerging scholarship on the romantic relationships of Black women refer to as “situationships.” Black women, those with higher incomes, and queer-identified women were more likely to use situationships. We argue that women’s use of situationships challenged normative expectations that felt constraining to many at midlife and allowed women to enjoy the benefits of sexual and romantic company. Situationships enabled them to avoid casual sex and maintain autonomy and single identity. Finally, we highlight the disadvantages of situationships, emphasizing the importance of life stage and orientation to normative arrangements for situationship experiences.
Views of Intermarried Couples: Implications for Social Work Practice
Authors: Greif Geoffrey L , Woolley Michael E , Stubbs Victoria D 
Published: April 2024

Abstract
Intermarriage, defined here as the marriage between people of different races or different ethnicities, is on the rise in the United States, with one in six newlyweds intermarrying. While public opinion approval of interracial marriage is at an all-time high, racial and ethnic hate crimes are also on the rise, which can affect spouses differently based on their identity. Drawing on a 2022 Qualtrics sample of 287 spouses who intermarried and have children, authors of this article sought to learn what is related to their holding a positive view of intermarriage. Talking openly with one’s spouse about differences, children initiating discussions about race, and being consciously aware of the interracial or interethnic aspect of the marriage were predictors. Implications for social work practice, which are predicated on the ability to have open communication between family members and the social worker’s comfort with their own racial identity, are included for this growing population of intermarried couples.
U.S. Social Work Students and Social Media: A Descriptive Analysis of Survey Items across Four Time-Points
Authors: Ricciardelli Lauren A 
Published: April 2024

Abstract
Between fall 2018 and spring 2023, the author conducted four survey studies on social work students’ use, attitudes, and knowledge regarding social media: (1) a pilot study in fall 2018 (N = 57), (2) a comparative study in spring 2019 (N = 42), (3) a national survey study in fall 2019 (N = 430), and (4) a national replication survey study in spring 2023 (N = 287). The purpose of this article is to describe general observed trends across these four studies. Findings included persistent and pervasive use of social media, decreased knowledge of the impact of social media in undermining democratic processes, students’ inverted concern for others’ use of social media when compared with concern over their own use, diminished agreement with the importance of protecting personal data and treating data protection as a civil/human right, overall agreement that law enforcement should be able to use social media in the apprehension of people accused of committing a crime, decreased agreement that disinformation is a problem on social media, ambivalence toward social media’s positive impact on society, and increased strong disagreement that students wish to delete their accounts but feel unable to do so. Recommendations are shared.
Intracranial Pressure and Cerebral Hemodynamics in Infants Before and After Glenn Procedure
Authors: Jijeh Abdulraouf M. Z. , Fatima Anis , Faraji Mohammad A. , Hamadah Hussam K. , Shaath Ghassan A. 
Published: April 2024

OBJECTIVES:
This prospective cohort study aimed to investigate changes in intracranial pressure (ICP) and cerebral hemodynamics in infants with congenital heart disease undergoing the Glenn procedure, focusing on the relationship between superior vena cava pressure and estimated ICP.

DESIGN:
A single-center prospective cohort study.

SETTING:
The study was conducted in a cardiac center over 4 years (2019–2022).

PATIENTS:
Twenty-seven infants with congenital heart disease scheduled for the Glenn procedure were included in the study, and detailed patient demographics and primary diagnoses were recorded.

INTERVENTIONS:
Transcranial Doppler (TCD) ultrasound examinations were performed at three time points: baseline (preoperatively), postoperative while ventilated (within 24–48 hr), and at discharge. TCD parameters, blood pressure, and pulmonary artery pressure were measured.

MEASUREMENTS AND MAIN RESULTS:
TCD parameters included systolic flow velocity, diastolic flow velocity (dFV), mean flow velocity (mFV), pulsatility index (PI), and resistance index. Estimated ICP and cerebral perfusion pressure (CPP) were calculated using established formulas. There was a significant postoperative increase in estimated ICP from 11 mm Hg (interquartile range [IQR], 10–16 mm Hg) to 15 mm Hg (IQR, 12–21 mm Hg) postoperatively (p = 0.002) with a trend toward higher CPP from 22 mm Hg (IQR, 14–30 mm Hg) to 28 mm Hg (IQR, 22–38 mm Hg) postoperatively (p = 0.1). TCD indices reflected alterations in cerebral hemodynamics, including decreased dFV and mFV and increased PI. Intracranial hemodynamics while on positive airway pressure and after extubation were similar.

CONCLUSIONS:
Glenn procedure substantially increases estimated ICP while showing a trend toward higher CPP. These findings underscore the intricate interaction between venous pressure and cerebral hemodynamics in infants undergoing the Glenn procedure. They also highlight the remarkable complexity of cerebrovascular autoregulation in maintaining stable brain perfusion under these circumstances.
Daptomycin Exposure Prediction With a Limited Sampling Strategy
Authors: De Gregori Simona , Seminari Elena , Capone Mara , Giordani Paola , Bruno Raffaele , De Silvestri Annalisa 
Published: April 2024

Background:
Daptomycin is a cyclic lipopeptide antibiotic used to treat serious infectious endocarditis caused by Staphylococcus aureus. The pharmacodynamic parameter correlating best with efficacy is the ratio of the estimated area under the concentration (AUC0-24)–time curve to the minimum inhibitory concentration. The aim of the study is to develop a limited sampling strategy to estimate AUC0-24 using a reduced number of samples.

Methods:
Sixty-eight daptomycin AUC0-24 values were calculated for 50 White patients who underwent treatment for at least 5 consecutive days. Plasma concentrations were detected using a validated high-performance liquid chromatography–tandem mass spectrometry analytical method, with daptomycin-d5 as an internal standard. Multiple regression was used to evaluate the ability of 2 concentration–time points to predict the AUC0-24 calculated from the entire pharmacokinetic profile. Prediction bias was calculated as the mean prediction error, whereas prediction precision was estimated as the mean absolute prediction error. The development and validation datasets comprised 40 and 10 randomly selected patients, respectively.

Results:
The AUC0-24 (mg*h/L) was best estimated using the daptomycin trough concentration and plasma concentrations detected 2 hours after dosing. We calculated a mean prediction error of 1.6 (95% confidence interval, −10.7 to 10.9) and a mean absolute prediction error of 11.8 (95% confidence interval, 5.3–18.3), with 73% of prediction errors within ±15%.

Conclusions:
An equation was developed to estimate daptomycin exposure (AUC0-24), offering clinical applicability and utility in generating personalized dosing regimens, especially for individuals at high risk of treatment failure or delayed response.