bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning based prediction of kidney function deterioration in infective endocarditis
Authors: Kang Min Woo , Kang Yoonjin 
Published: May 2024

Abstract

Background: Acute kidney injury in infective endocarditis presents significant management challenges in intensive care unit (ICU). We explored the role of mean blood pressure(MBP) at the time of ICU admission predicting kidney function outcomes in endocarditis patients using deep learning model, Generative Adversarial Nets for inference of Individualized Treatment Effects (GANITE).
Methods: This study utilized data from the Medical Information Mart for Intensive Care III database. Patients with infective endocarditis admitted to intensive care unit were included in this study. A machine learning model was developed to predict the kidney function deterioration. SHapley Additive exPlanations (SHAP) were used to understand how variables affect kidney function. Moreover, the GANITE model, a causal inference deep learning model, was used to determine the effect of blood pressure to kidney function.
Results. A total of 484 patients were included in the analysis, among whom 85(17.6%) experienced kidney deterioration. Light gradient boosting machine, extreme gradient boosting, and the ensemble model showed area under the receiver operating characteristics of 0.790, 0.772, and 0.785, respectively, on the test data, all achieving an accuracy of 0.828. SHAP value plots revealed that higher blood pressure predicted a lower likelihood of kidney deterioration. Analysis using the GANITE model revealed that maintaining MBP≥65mmHg resulted in a decrease in the probability of kidney deterioration by 12.9%.
Conclusions: In patients with infective endocarditis in ICU, the maintenance of MBP≥65mmHg prevented the future kidney function deterioration after ICU admission.
Awareness on Covid-19 Waste Management Among Health Care Professionals: a Case Study in Dhaka City
Authors: AFROZ TURIN 
Published: May 2024

Abstract

The research was conducted on awareness of COVID-19 waste management among health care workers. The study aimed to figure out existing scenario of COVID-19 waste segregation practice and developed awareness of highly contagious COVID-19 waste among waste dealing workers. A descriptive type of cross sectional study were performed through simple random sampling technique among health care professionals. The study revealed that all had knowledge about adverse effects of biomedical waste ,only 38% used PPE where 86% received training on that.82% received training on COVID-19 waste management but only 42% segregated COVID-19 waste in workplace .Moreover ,53.94% respondents mixed COVID − 19 waste with normal waste. The prevalence of COVID-19 was 1.92 times greater in trained worker than in non-trained worker due to their poor waste segregation practice. For that reason, Health care worker had 2.05 times higher likelihood of having the disease compared to the untrained worker during first two month of their infection. It is high time to change their practice.Finally the research will be helpful in planning and allocation of health resources. More awareness should be developed among health care worker.
Normative Computed Tomography Angiography Values of the Aortic Root, Aorta and Aortic arch in Children
Authors: Donthula Rakesh , Li Wen , Duvvada Archita , Dyer Dan , Uppu Santosh C. 
Published: May 2024

Abstract

Purpose
Normative values for intracardiac and extracardiac vascular structures help in understanding normal growth and changes over time in children; this normative data are not currently available for ECG-gated Computed Tomography Angiography (CTA). We sought to establish ECG-gated CTA derived normative values for the aortic root, aorta and aortic arch in children.
Methods and Results
Aortic root, ascending aorta, aortic arch, and descending aorta were measured in systole and diastole in 100 subjects who had ECG-gated CTA at our center between January 2015 through December 2020 and met our inclusion criteria. The allometric exponent (AE) for each parameter was derived, and the parameter/body surface areaAE (BSAAE) was established using the previously described methods. Using this data, normalized mean, cross-sectional area, and standard deviation were calculated. Z-score curves were plotted in relation to the BSA for all measurements.
Conclusion
Our study reports systolic and diastolic ECG-gated CTA Z-scores along with normative curves in relation to BSA for the aortic root, aorta and aortic arch in children.
Curcumin Nanogel Preparations: A Promising Alternative for Psoriasis Treatment
Authors: Ahmad Asad , Akhtar Juber , Ahmad Mohammad , Islam Anas , Badruddeen  , Khan Mohammad Irfan , Siddiqui Shaiber , Srivastava Akash 
Published: May 2024

:
Curcumin is a naturally occurring polyphenolic compound extracted from the rhizomes of Curcuma
longa, commonly known as turmeric. It has been used for centuries in traditional medicine and is gaining increasing
attention in modern medicine owing to its potential therapeutic benefits. Psoriasis is a chronic inflammatory
disease characterized by red scaly patches on the skin. Curcumin has been found to be effective in treating
psoriasis by inhibiting the activity of various enzymes and proteins involved in the inflammation and proliferation
of psoriatic skin cells. Nanogel preparation of curcumin has been found to be a promising approach for
the delivery of compounds to treat psoriasis. Nanogels are composed of biocompatible and biodegradable
crosslinked hydrogels. The nanogel formulation of curcumin increases its solubility, stability, and bioavailability,
indicating that a lower dose is needed to achieve the same therapeutic effect. This review article suggests
that the nanogel preparation of curcumin can be a better alternative for psoriasis treatment as it increases the
bioavailability and stability of curcumin and also reduces the required dosage. This study suggests that curcumin
nanogel preparations are promising alternatives to traditional psoriasis treatments and could potentially be
used as a more effective and safe treatment option. This article highlights the need for further research to fully
understand the potential of curcumin nanogel preparations for psoriasis treatment in humans.
Evaluation of HIV and Syphilis Co-infected Cases, Data from a University
Hospital
Authors: Kömür Süheyla , Ertürk Damla , Sevdimbaş Sezin , Kuşcu Ferit , İnal Ayşe Seza , Kurtaran Behice , Candevir Aslıhan , Taşova Yeşim 
Published: May 2024

Background:
HIV and syphilis are sexually transmitted infections with overlapping
risk factors, potentially leading to increased HIV transmission and treatment challenges. Understanding
the clinical management of syphilis co-infection among people living with HIV is crucial
for public health interventions.

Objective:
This retrospective cohort study aimed to assess the prevalence of syphilis co-infection,
clinical characteristics, treatment response, and public health implications among people living
with HIV in southern Turkey

Methods:
Records of 1352 people living with HIV 18 years and older, followed at a tertiary infectious
diseases clinic between 2013 and 2023, were analyzed. Data on demographics, clinical stage
of syphilis and HIV/AIDS, laboratory parameters, treatment response, and co-infections were collected.
Statistical analyses were performed using SPSS 20.0 software.

Results:
Among the people living with HIV, 103 (7.6%) were diagnosed with syphilis. Most cases
were male (97.1%), with a median age of 33 (IQR 28-49) years. Heterosexual transmission was
predominant (60.2%), with a history of condomless sexual intercourse in 90.3% of cases. The majority
(88.3%) were asymptomatic with latent syphilis. Syphilis was diagnosed concurrently with
HIV in 77.7% of cases. Serological response to syphilis treatment was observed in 46.8% of patients,
while 53.2% showed a serofast reaction. Neurosyphilis was rare, diagnosed in only one patient.
Co-infections with hepatitis B and C were detected in 3.9% and 1.9% of patients, respectively.

Conclusion:
Syphilis co-infection among people living with HIV is a significant public health
concern in southern Turkey. Routine screening for syphilis, along with comprehensive education
on sexually transmitted infection prevention, is essential for early detection and optimal management.
Further research is needed to improve treatment outcomes and address emerging challenges
in HIV-syphilis co-infection management.
Imaging Diagnosis of Retroperitoneal Müllerian Duct-derived Cyst Complicated
by Diaphragmatic Hernia: A Case Report
Authors: Tang Fuqiang , Zhang Jing 
Published: May 2024

Background::
This case report describes a case of Müllerian duct cyst that occurred in a male retroperitoneum. The cyst lesion is rare and complicated with
diaphragmatic hernia. Müllerian duct-derived cyst is a rare developmental disorder that is more common in male pelvic tissues and rare in the
retroperitoneum. We investigated the important role of computerized tomography (CT) and magnetic resonance imaging (MRI) in preoperative
diagnosis and disease prediction of this condition

Case Presentation::
A 25-year-old male was found to have an abnormal occupying lesion in the left diaphragm in imaging examinations, usually healthy with no
obvious clinical symptoms. X-ray examination showed a circular, high-density shadow near the left diaphragm. CT scan showed a soft tissue
density shadow resembling a tumor in the left adrenal area, irregularly protruding into the chest cavity, with uneven density. MRI examination
showed an irregular elongated T1 and T2 signal shadow in the left adrenal area. T2 fat suppression showed high signal intensity with unrestricted
diffusion. Robotic-assisted laparoscopic surgery showed left retroperitoneal tumor resection. The patient recovered well postoperatively and had no
recurrence after discharge follow-up.

Conclusion::
The preclinical symptoms of retroperitoneal Müllerian cysts complicated by diaphragmatic hernia in young men are difficult to distinguish, and it
is difficult to diagnose other similar cysts with imaging. The method of combined CT and MRI diagnosis guides the endoscopic robot-assisted
minimally invasive surgery for excision of cysts to achieve accurate diagnosis and treatment of such diseases.
In vitro and In vivo Biological Activity of Two Aryloxy-naphthoquinones in Mice Infected with Trypanosoma cruzi Strains
Authors: Vázquez Karina , Moreno-Rodríguez Adriana , Domínguez-Díaz Luis R. , Bertrand Jeanluc , Salas Cristian O. , Rivera Gildardo , Cervera Yobana Pérez , Bocanegra-García Virgilio 
Published: May 2024

Background:
Chagas disease, a condition caused by Trypanosoma cruzi, is an endemic
disease in Latin American countries that affects approximately eight million people worldwide. It is
a continuing public health problem. As nifurtimox and benznidazole are the two pharmacological
treatments currently used to treat it, the present research proposes new therapeutic alternatives.
Previous studies conducted on naphthoquinone derivatives have found interesting trypanocidal
effects on epimastigotes, with the molecules 2-phenoxy-1,4-naphthoquinone (IC50= 50 nM and SI <
250) and 2-(3-nitrophenoxy)-naphthalene-1,4-dione (IC50= 20 nM and SI=625) presenting the best
biological activity.

Methods:
The present study evaluated the efficacy of in vitro, ex vivo and in vivo models of two
aryloxyquinones, 2-phenoxy-1,4-naphthoquinone (1) and 2-(3-nitrophenoxy)-naphthalene-1,4-
dione (2), against two Mexican T. cruzi strains in both their epimastigote and blood Trypomastigote
stage. Both compounds were evaluated against T. cruzi using a mouse model (CD1) infected with
Mexican isolates of T. cruzi, nifurtimox and benznidazole used as control drugs. Finally, the cytotoxicity
of the two compounds against the J774.2 mouse macrophage cell line was also determined.

Results:
The in vitro and in vivo results obtained indicated that both quinones were more active
than the reference drugs. Compound 1 presents in vivo activity, showing up to 40% parasite reduction
after 8 h of administration, a finding which is 1.25 times more effective than the results obtained
using nifurtimox.

Conclusion:
These are encouraging results for proposing new naphthoquinone derivatives with
potential anti-T. cruzi activity.
Is Antipsychotic Drug Use During Pregnancy Associated with Increased Malformation Rates and Worsening of Maternal and Infant Outcomes? A Systematic Review
Authors: Sani Gabriele , Callovini Tommaso , Ferrara Ottavia Marianna , Segatori Daniele , Margoni Stella , Simonetti Alessio , Lisci Francesco Maria , Marano Giuseppe , Fischetti Alessia , Kotzalidis Georgios D. , Di Segni Federica , Fiaschè Federica , Janiri Delfina , Moccia Lorenzo , Manfredi Giovanni , Alcibiade Alessandro , Brisi Caterina , Grisoni Flavia , Stella Gianmarco , Bernardi Evelina , Brugnami Andrea , Ciliberto Michele , Spera Maria Chiara , Caso Romina , Rossi Sara , Boggio Gianluca , Mastroeni Giulia , Abate Francesca , Conte Eliana , Quintano Anna , De Chiara Lavinia , Monti Laura , Camardese Giovanni , Rinaldi Lucio , Koukopoulos Alexia E. , Chieffo Daniela Pia Rosaria , Angeletti Gloria , Mazza Marianna 
Published: May 2024

:
There is much debate about continuing antipsychotic medication in patients who need it when
they become pregnant because benefits must be weighed against potential teratogenic and malformation
effects related to antipsychotics themselves. To address this, we conducted a systematic review on the
PubMed, PsycINFO and CINHAL databases and the ClinicalTrials.gov register using the following strategy: (toxicity OR teratogenicity OR malformation* OR "birth defect*" OR "congenital abnormality" OR
"congenital abnormalities" OR "brain changes" OR "behavioral abnormalities" OR "behavioral abnormalities") AND antipsychotic* AND (pregnancy OR pregnant OR lactation OR delivery OR prenatal OR
perinatal OR post-natal OR puerperium) on September 27, 2023. We found 38 studies to be eligible. The
oldest was published in 1976, while most articles were recent. Most studies concluded that the antipsychotics, especially the second-generation antipsychotics, were devoid of teratogenic potential, while few
studies were inconclusive and recommended replication. Most authoritative articles were from the Boston
area, where large databases were implemented to study the malformation potential of psychiatric drugs.
Other reliable databases are from Northern European registers. Overall conclusions are that antipsychotics are no more related to malformations than the disorders themselves; most studies recommend that
there are no reasons to discontinue antipsychotic medications in pregnancy
Feasibility of Fit24, a Digital Diabetes Prevention Program for Hispanic Adolescents: Qualitative Evaluation Study
Authors: Soltero Erica G , Musaad Salma M , O’Connor Teresia M , Thompson Debbe , Norris Keith , Beech Bettina M 
Published: May 2024

Background
Digital health interventions are promising for reaching and engaging high-risk youth in disease prevention opportunities; however, few digital prevention interventions have been developed for Hispanic youth, limiting our knowledge of these strategies among this population.

Objective
This study qualitatively assessed the feasibility and acceptability of Fit24, a 12-week goal-setting intervention that uses a Fitbit watch (Fitbit Inc) and theoretically grounded SMS text messages to promote physical activity and sleep among Hispanic adolescents (aged between 14 and 16 years) with obesity.

Methods
After completing the intervention, a subsample of youth (N=15) participated in an in-depth interview. We categorized the themes into dimensions based on participant perspectives using the Practical, Robust Implementation, and Sustainability Model (PRISM) framework.

Results
Participants shared positive perceptions of wearing the Fitbit and receiving SMS text messages. Youth were highly engaged in monitoring their behaviors and perceived increased activity and sleep. Almost all youth organically received social support from a peer or family member and suggested the use of a group chat or team challenge for integrating peers into future interventions. However, most youth also expressed the need to take personal responsibility for the change in their behavior. Barriers that impacted the feasibility of the study included the skin-irritating material on the Fitbit watch band and environmental barriers (eg, lack of resources and school schedules), that limited participation in activity suggestions. Additionally, sync issues with the Fitbit limited the transmission of data, leading to inaccurate feedback.

Conclusions
Fit24 is a promising approach for engaging Hispanic youth in a diabetes prevention program. Strategies are needed to address technical issues with the Fitbit and environmental issues such as message timing. While integrating peer social support may be desired by some, peer support strategies should be mindful of youth’s desire to foster personal motivation for behavior change. Findings from this study will inform future diabetes prevention trials of Fit24 and other digital health interventions for high-risk pediatric populations.
Literature Study on Network Society in Indonesia 1977-2022
Authors: Putra Ferdian Ahya Al , Prakoso Septyanto Galan , Ardita Nadia Dian 
Published: May 2024

Saat ini, terdapat kelangkaan studi literatur yang tentang perkembangan masyarakat jaringan di Indonesia. Kajian untuk mengetahui topik-topik yang seharusnya mendapat perhatian lebih dari para akademisi dalam bidang ini, harus dilakukan. Studi terkait masyarakat jaringan yang ada saat ini masih cenderung bersifat umum dan tidak membahas detail dari topik dan isu yang mempengaruhi masyarakat jaringan di Indonesia. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi keberadaan masyarakat jaringan dan isu-isu yang ada dalam masyarakat jaringan di Indonesia dari tahun 1977 hingga 2022 dari sudut pandang para akademisi melalui publikasi mereka dengan menggunakan studi literatur berbasis database Scopus dengan visualisasi data. Penelitian dilakukan melalui studi pustaka dengan fokus pada data bibliografis. Visualisasi data akan disajikan menggunakan program Vos Viewer, dengan pengambilan data menggunaan program Publish or Perish. Hasil dari penelitian ini menunjukkan bahwa fokus dari masyarakat jaringan di Indonesia dipengaruhi oleh fenomena yang pernah terjadi dan masih ada di dalam negeri. Artikel ini diharapkan dapat menjadi titik awal bagi riset-riset yang bertujuan untuk menemukan tren dalam masyarakat jaringan di Indonesia, dan juga menyediakan acuan untuk bentuk penelitian yang membahas mengenai masyarakat jaringan di Indonesia dengan lebih detail dan terkait fokus topik seperti isu keamanan, pendidikan, dan sebagainya.

Currently, there is a scarcity of a proper literature study on the development of network society in Indonesia. A study to examine this field, as well as to know the topics which have gained more attention from the scholars, should be done. This serves as a purpose to scrutinize the existence of network society in Indonesia. The projected study should also be conducted based on reliable data from time to time as a result of scientific thinking. Therefore, this study aims to identify the existence of network society in Indonesia from 1977 to 2022 from the perspective of the scholars through their publication by using literature study based on Scopus database with data visualization. Data visualization will be presented using the Vos Viewer program. Thus, this paper can be used to discover the trends within network society in Indonesia, and also provide a checkpoint to similar forms of research.
Eksplorasi Elemen Digital Storytelling dalam Konten Gaming Youtube Kids
Authors: Puspita Birgitta Bestari , Edvra Paulus A. 
Published: May 2024

Konten-konten yang dapat diakses melalui YouTube Kids adalah konten yang memiliki target audiens anak-anak dengan karakter khusus yang perlu diperhatikan oleh pembuat konten agar pesan yang disampaikan dapat diterima dan dipahami dengan baik oleh anak-anak. Penelitian terkait digital storytelling terutama pada konten game masih cukup sulit ditemukan. Penelitian ini bertujuan untuk mengeksplorasi elemen-elemen digital storytelling dalam konten game YouTube Kids, terutama konten game walkthrough atau konten panduan game. Metode penelitian yang digunakan adalah analisis isi kualitatif. Konten yang dipilih adalah konten popular, berusia tidak lebih dari lima tahun yang video dan akun pembuatnya dapat secara khusus diakses melalui YouTube Kids. Hasil penelitian menunjukkan bahwa tidak semua video yang ditujukan untuk anak-anak menerapkan elemen digital storytelling yang sesuai untuk anak, termasuk elemen yang sesuai dengan perkembangan moral anak. Penggunaan elemen-elemen dalam digital storytelling bisa menjadi preferensi narator cerita sehingga penggunaannya pun bisa berbeda antara satu narator dengan narator lainnya. Namun demikian, pertimbangan target audiens mestinya menjadi salah satu hal yang utama untuk diperhatikan oleh narator. Penelitian ini merupakan penelitian awal, akan tetapi sudah dapat memberikan gambaran terkait elemen digital storytelling dalam konten YouTube Kids terkait game walkthrough, yang dapat diperdalam dalam penelitian selanjutnya dalam topik khusus yang sama.

The contents accessible through YouTube Kids are designed for a child audience and feature specific characters. Content creators need to pay attention to these characters to ensure that the messages conveyed are well-received and understood by children. Research on digital storytelling, especially in the context of game content, is still relatively scarce. This study aims to explore the elements of digital storytelling in YouTube Kids game content, particularly in game walkthroughs or guide content. The research method employed is qualitative content analysis. The selected content includes popular videos, not more than five years old, and accounts that are specifically accessible through YouTube Kids. The results indicate that not all videos intended for children include appropriate digital storytelling elements, including those aligned with children's moral development. The use of elements in digital storytelling can vary depending on the story narrator's preferences, leading to differences between narrators. However, the consideration of the target audience should be a primary concern for narrators. While this study is preliminary, it provides insights into the digital storytelling elements in YouTube Kids content related to game walkthroughs, which can be further explored in subsequent research on the same specific topic.