bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consistency of affective responses to naturalistic stimuli across individuals using intersubject correlation analysis based on neuroimaging data
Authors: Jang Junhyeok , Kim Jongwan 
Published: June 2024

ABSTRACTIn this study, we used functional magnetic resonance imaging (fMRI) data obtained for naturalistic emotional stimuli to examine the consistency of neural responses among participants in specific regions related to valence. We reanalyzed fMRI data from 17 participants as they watched episodes of “Sherlock” and used emotional ratings from 125 participants. To determine regions where neural response patterns were synchronized across participants based on the pattern of valence changes, intersubject correlation analysis was conducted. As a validation analysis, multidimensional scaling was conducted to investigate emotional representation for significant regions of interest. The results revealed that the ventromedial prefrontal cortex, bilateral superior frontal cortices, left posterior cingulate cortex, thalamus, right anterior cingulate cortex, and bilateral inferior frontal cortices showed increased neural synchrony as positive scenes were presented. Also, the bilateral superior temporal gyrus and bilateral medial temporal gyrus exhibited increased neural synchrony as negative scenes were presented. Moreover, the left inferior frontal cortex and right superior frontal gyrus were found to be engaged in emotion representation and display increased neural synchrony. These findings provide insights into the differential neural responses to emotionally evocative naturalistic stimuli as compared to conventional experimental stimuli. Also, this study highlights the future potential for using intersubject correlation analysis for examining consistency of neural responses to naturalistic stimuli.
Benchmarking of a multi-biomarker low-volume panel for Alzheimer’s Disease and related dementia research
Authors: Ibanez Laura , Liu Menghan , Beric Aleksandra , Timsina Jigyasha , Kholfeld Pat , Bergmann Kristy , Lowery Joey , Sykora Nick , Sanchez-Montejo Brenda , Brock Will , Budde John P. , Bateman Randall J. , Barthelemy Nicolas , Schindler Suzanne E. , Holtzman David M , Benzinger Tammie L. S. , Xiong Chengjie , Tarawneh Rawan , Moulder Krista , Morris John C. , Sung Yun Ju , Cruchaga Carlos 
Published: June 2024

AbstractAlzheimer’s Disease (AD) biomarker measurement is key to aid in the diagnosis and prognosis of the disease. In the research setting, participant recruitment and retention and optimization of sample use, is one of the main challenges that observational studies face. Thus, obtaining accurate established biomarker measurements for stratification and maximizing use of the precious samples is key. Accurate technologies are currently available for established biomarkers, mainly immunoassays and immunoprecipitation liquid chromatography-mass spectrometry (IP-MS), and some of them are already being used in clinical settings. Although some immunoassays- and IP-MS based platforms provide multiplexing for several different coding proteins there is not a current platform that can measure all the stablished and emerging biomarkers in one run. The NUcleic acid Linked Immuno-Sandwich Assay (NULISA™) is a mid-throughput platform with antibody-based measurements with a sequencing output that requires 15µL of sample volume to measure more than 100 analytes, including those typically assayed for AD. Here we benchmarked and compared the AD-relevant biomarkers including in the NULISA against validated assays, in both CSF and plasma. Overall, we have found that CSF measures of Aß42/40, NfL, GFAP, and p-tau217 are highly correlated and have similar predictive performance when measured by immunoassay, mass-spectrometry or NULISA. In plasma, p-tau217 shows a performance similar to that reported with other technologies when predicting amyloidosis. Other established and exploratory biomarkers (total tau, p-tau181, NRGN, YKL40, sTREM2, VILIP1 among other) show a wide range of correlation values depending on the fluid and the platform. Our results indicate that the multiplexed immunoassay platform produces reliable results for established biomarkers in CSF that are useful in research settings, with the advantage of measuring additional novel biomarkers using minimal sample volume.
Ultra-processed foods and hypertension incidence in RaNCD cohort project
Authors: Amirian Parsa , Zarpoosh Mahsa , Pasdar Yahya 
Published: June 2024

AbstractBackgroundDue to rapid population growth and, subsequently, large-scale food production methods, ultra-processed food consumption is in parabolic growth. By affecting 1.28 billion adults globally, hypertension is a major risk factor and cause of premature death. In order to find the relation between ultra-processed food consumption and other covariates with hypertension incidence, this study was conducted in the western part of Iran using RaNCD prospective cohort data.MethodsWe included 8150 participants at the risk of hypertension in the final analysis. Using the data obtained from the Iranian food frequency questionnaire and the NOVA food classification, we assessed the ultra-processed food consumption of each participant in a day. Logistic regression models and the Cox proportional hazards regression model were used to assess the association between ultra-processed food consumption and hypertension in the main model and sensitivity analysis.ResultsThe mean age of participants was 46.25y ± 7.94 (47.58% males); the mean follow-up time was 7.65y ± 1.62, and the mean daily UPF intake in g/d among participants was 88.07 ± 84.96. During the follow-up period, 862 cases of hypertension were recorded. We adjusted the main model for several confounders, including age, gender, residence type, marital status, socioeconomic status, physical activity, body mass index, familial history of hypertension, fasting blood sugar, and waist-to-hip ratio. The odds ratio and 95% confidence interval (95% CI) of the second and third tertile of UPFs were 1.15 (95% CI, 0.96-1.37) and 1.03 (95%CI, 0.85-1.24), respectively, compared to the first tertile with insignificant p-value & p-trend.ConclusionTo the best of our knowledge, our study is the first to assess the association between hypertension and ultra-processed foods in the Middle East region. Significant associations between hypertension incidence and some confounders were also identified.
Metabolism-Disrupting Chemical Mixtures during Pregnancy, Folic Acid Supplementation, and Liver Injury in Mother-Child Pairs
Authors: India-Aldana Sandra , Midya Vishal , Betanzos-Robledo Larissa , Yao Meizhen , Alcalá Cecilia , Andra Syam S. , Arora Manish , Calafat Antonia M. , Chu Jaime , Deierlein Andrea , Estrada-Gutierrez Guadalupe , Jagani Ravikumar , Just Allan C. , Kloog Itai , Landero Julio , Oulhote Youssef , Walker Ryan W. , Yelamanchili Shirisha , Baccarelli Andrea A. , Wright Robert O. , Téllez Rojo Martha María , Colicino Elena , Cantoral Alejandra , Valvi Damaskini 
Published: June 2024

AbstractBackground and AimsScarce knowledge about the impact of metabolism-disrupting chemicals (MDCs) on liver injury limits opportunities for intervention. We evaluated pregnancy MDC-mixture associations with liver injury and effect modification by folic acid (FA) supplementation in mother-child pairs.MethodsWe studied ∼200 mother-child pairs from the Mexican PROGRESS cohort, with measured 43 MDCs during pregnancy (estimated air pollutants, blood/urine metals or metalloids, urine high- and low-molecular-weight phthalate [HMWPs, LMWPs] and organophosphate-pesticide [OP] metabolites), and serum liver enzymes (ALT, AST) at ∼9 years post-parturition. We defined liver injury as elevated liver enzymes in children, and using established clinical scores for steatosis and fibrosis in mothers (i.e., AST:ALT, FLI, HSI, FIB-4). Bayesian Weighted Quantile Sum regression assessed MDC-mixture associations with liver injury outcomes. We further examined chemical-chemical interactions and effect modification by self-reported FA supplementation.ResultsIn children, many MDC-mixtures were associated with liver injury outcomes. Per quartile HMWP-mixture increase, ALT increased by 10.1% (95%CI: 1.67%, 19.4%) and AST by 5.27% (95% CI: 0.80%, 10.1%). LMWP-mixtures and air pollutant-mixtures were associated with higher AST and ALT, respectively. Air pollutant and non-essential metal/element associations with liver enzymes were attenuated by maternal cobalt blood concentrations (p-interactions<0.05). In mothers, only the LMWP-mixture was associated with liver injury [OR=1.53 (95%CI: 1.01, 2.28) for HSI>36, and OR=1.62 (95%CI: 1.05, 2.49) for AST:ALT<1]. In mothers and children, most associations were attenuated (null) at FA supplementation≥600mcg/day (p-interactions<0.05).ConclusionsPregnancy MDC exposures may increase liver injury risk, particularly in children. These associations may be attenuated by higher FA supplementation and maternal cobalt levels.
Female Brain and Endocrinological Research – Veteran (FemBER-Vet) Study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health outcomes in female veterans for future intervention success
Authors: Watermeyer Tamlyn , Atkinson Elliott , Howatson Glyn , McGill Gill , Dodds Christina , Ansdell Paul , Udeh-Momoh Chinedu 
Published: June 2024

BackgroundRecent studies have demonstrated a greater risk of dementia in female veterans compared to civilians; with the highest prevalence noted for former service women with a diagnosis of psychiatric (trauma, alcoholism, depression), and/or a physical health condition (brain injury, insomnia, diabetes). Such findings highlight the need for increased and early screening of medical and psychiatric conditions, and indeed dementia, in the female veteran population. Further, they call for a better understanding of the underlying biopsychosocial mechanisms that might confer heightened risk for female veterans, to tailor preventative and interventional strategies that support brain health across the lifespan.MethodsThe Female Brain and Endocrinological Research – Veteran (FemBER-Vet) Study will create a highly-phenotyped readiness cohort of ex-service persons as well as non-veterans to assess the impacts of, and risks associated with, military service on brain health, using state-of-the-art non-invasive cognitive, physiological and biomarker capture techniques. FEMBER-Vet will include 90 participants across three study groups (30 female veterans, 30 male veterans, 30 female civilians) to delineate the precise biological, socio-demographic, health, lifestyle, military-related, and life-course determinants of brain health outcomes (psychosocial, cognitive, neurophysiological, and other biomarkers).DiscussionThis work addresses the poorly understood biopsychosocial outcomes that female veterans experience compared to their male counterparts and the general female population. Ultimately, it will provide evidence to support the development of tailored interventions for an emerging health priority that currently lacks sufficient evidence for screening and therapeutic intervention.
Tripartite organization of brain state dynamics underlying spoken narrative comprehension
Authors: Liu Lanfang , Jiang Jiahao , Li Hehui , Ding Guosheng 
Published: June 2024

AbstractSpeech comprehension involves the dynamic interplay of multiple cognitive processes, from basic sound perception, to linguistic encoding, and finally to complex semantic-conceptual interpretations. How the brain handles the diverse streams of information processing remains poorly understood. Applying Hidden Markov Modeling to fMRI data obtained during spoken narrative comprehension, we reveal that the whole brain networks predominantly oscillate within a tripartite latent state space. These states are respectively characterized by high activities in the sensory-motor (State #1), bilateral temporal (State #2), and DMN (State #3) regions, with State #2 acting as a transitional hub. The three states are selectively modulated by the acoustic, word-level semantic and clause-level semantic properties of the narrative. Moreover, the alignment with the best performer in brain state expression can predict participants’ narrative comprehension scores. These results are reproducible with different brain network atlas and generalizable to two datasets consisting of young and older adults. Our study suggests that the brain underlies narrative comprehension by switching through a tripartite state space, with each state probably dedicated to a specific component of language faculty, and effective narrative comprehension relies on engaging those states in a timely manner.
Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s disease
Authors: Malla Sulochan , Bryant Annie G. , Jayakumar Rojashree , Woost Benjamin , Wolf Nina , Li Andrew , Das Sudeshna , van Veluw Susanne J. , Bennett Rachel E. 
Published: June 2024

AbstractWhite matter hyperintensities (WMHs) are commonly detected on T2-weighted magnetic resonance imaging (MRI) scans, occurring in both typical aging and Alzheimer’s disease. Despite their frequent appearance and their association with cognitive decline, the molecular factors contributing to WMHs remain unclear. In this study, we investigated the transcriptomic profiles of two commonly affected brain regions with coincident AD pathology—frontal subcortical white matter (frontal-WM) and occipital subcortical white matter (occipital-WM)—and compared with age-matched healthy controls. Through RNA-sequencing in frontal- and occipital-WM bulk tissues, we identified an upregulation of genes associated with brain vasculature function in AD white matter. To further elucidate vasculature-specific transcriptomic features, we performed RNA-seq analysis on blood vessels isolated from these white matter regions, which revealed an upregulation of genes related to protein folding pathways. Finally, comparing gene expression profiles between AD individuals with high-versus low-WMH burden showed an increased expression of pathways associated with immune function. Taken together, our study characterizes the diverse molecular profiles of white matter changes in AD compared to normal aging and provides new mechanistic insights processes underlying AD-related WMHs.
Co-administration of midazolam and psilocybin: Differential effects on subjective quality versus memory of the psychedelic experience
Authors: Nicholas Christopher R. , Banks Matthew I. , Lennertz Richard L. , Wenthur Cody J. , Krause Bryan M. , Riedner Brady A. , Smith Richard F. , Hutson Paul R. , Sauder Christina J. , Dunne John D. , Roseman Leor , Raison Charles L. 
Published: June 2024

AbstractAspects of the acute experience induced by the serotonergic psychedelic psilocybin predict symptomatic relief in multiple psychiatric disorders and improved well-being in healthy participants, but whether these therapeutic effects are immediate or are based on memories of the experience is unclear. To examine this, we co-administered psilocybin (25 mg) with the amnestic benzodiazepine midazolam in 8 healthy participants and assayed the subjective quality of, and memory for, the dosing-day experience. We identified a midazolam dose that allowed a conscious psychedelic experience to occur while partially impairing memory for the experience. Furthermore, midazolam dose and memory impairment tended to associate inversely with salience, insight, and well-being induced by psilocybin. These data suggest a role for memory in therapeutically relevant behavioral effects occasioned by psilocybin. Because midazolam blocks memory by blocking cortical neural plasticity, it may also be useful for evaluating the contribution of the pro-neuroplastic properties of psychedelics to their therapeutic activity.
A NEW POSTURAL MOTOR RESPONSE TO SPINAL CORD STIMULATION: POST-STIMULATION REBOUND EXTENSION
Authors: Mahrous Amr A. , Chardon Matthieu , Johnson Michael , Miller Jack , Heckman CJ 
Published: June 2024

ABSTRACTSpinal cord stimulation (SCS) has emerged as a therapeutic tool for improving motor function following spinal cord injury. While many studies focus on restoring locomotion, little attention is paid to enabling standing which is a prerequisite of walking. In this study, we fully characterize a new type of response to SCS, a long extension activated post-stimulation (LEAP). LEAP is primarily directed to ankle extensors and hence has great clinical potential to assist postural movements. To characterize this new response, we used the decerebrate cat model to avoid the suppressive effects of anesthesia, and combined EMG and force measurement in the hindlimb with intracellular recordings in the lumbar spinal cord. Stimulation was delivered as five-second trains via bipolar electrodes placed on the cord surface, and multiple combinations of stimulation locations (L4 to S2), amplitudes (50-600 uA), and frequencies (10-40 Hz) were tested. While the optimum stimulation location and frequency differed slightly among animals, the stimulation amplitude was key for controlling LEAP duration and amplitude. To study the mechanism of LEAP, we performed in vivo intracellular recordings of motoneurons. In 70% of motoneurons, LEAP increased at hyperpolarized membrane potentials indicating a synaptic origin. Furthermore, spinal interneurons exhibited changes in firing during LEAP, confirming the circuit origin of this behavior. Finally, to identify the type of afferents involved in generating LEAP, we used shorter stimulation pulses (more selective for proprioceptive afferents), as well as peripheral stimulation of the sural nerve (cutaneous afferents). The data indicates that LEAP primarily relies on proprioceptive afferents and has major differences from pain or withdrawal reflexes mediated by cutaneous afferents. Our study has thus identified and characterized a novel postural motor response to SCS which has the potential to expand the applications of SCS for patients with motor disorders.
Robust fault-tolerant preview control for automatic landing of carrier-based aircraft
Authors: Xiao Huiyunuo , Zhen Ziyang , Zhang Zhibing , Zheng Fengying 
Published: June 2024

Purpose
This paper aims to propose the automatic carrier landing system with the fault-tolerant ability for carrier-based aircraft in the presence of deck motion, external airwake disturbance and actuator fault, which consists of the reference trajectory generation module and flight control module.

Design/methodology/approach
The longitudinal and lateral basic controllers are designed based on the optimal preview control (OPC), which can ensure favorable tracking performance and anti-disturbance ability of system. Furthermore, based on the OPC, the robust fault-tolerant preview control scheme is proposed to attenuate the impact of actuator fault on system, which ensures the safe landing of carrier-based aircraft in case of actuator failure.

Findings
Both the Lyapunov method and simulations prove that the tracking errors can converge to zero and system states can be asymptotically stable both in normal and fault operations.

Originality/value
The fault-tolerant control strategy is introduced into preview control to deal with actuator fault, which combines feedforward control based on future previewable information and feedback control based on current information to improve the system performance.
Gabapentin treatment for challenging behaviors in autism spectrum disorder and coexisting intellectual disability: a case report
Authors: Marini Stefano , D'Agostino Lucia , Ciamarra Carla , De Berardis Domenico , Gentile Alessandro 
Published: June 2024

Purpose
The purpose of this case report is to report the clinical experience of the use of gabapentin in the management of problem behaviors in a person with autism spectrum disorder and comorbid intellectual disability. Autism spectrum disorder is a neurodevelopmental disorder with a high prevalence of intellectual disability. Challenging behaviors in autism spectrum disorder are very common. In recent years, the hypothesis that the symptoms of autism derive from a deficiency of the inhibitory neurotransmission of gamma-aminobutyric acid is gaining considerable weight.

Design/methodology/approach
Exploring behavioral symptoms improvement in an adult man with ASD and severe intellectual disability taking gabapentin.

Findings
The rating scales used show improvement in challenging behaviors and aggressions. No side effects were observed.

Originality/value
Currently, there are no authorized drugs for the treatment of the symptomatic features of autism spectrum disorder, but drugs are used for comorbid psychopathological aspects. The authors want to speculate on a hypothetical function of gabapentin in remodeling the expression of alpha-2-delta subunits in people with autism and the processing of neural information.
Industry 4.0 and sustainability: the case of the Italian textile district of Prato
Authors: Ferlito Rosaria 
Published: June 2024

Purpose
The purpose of this paper is to analyze the twin transition of textile firms operating in an industrial district. The twin transition comprises two interconnected but distinct processes: the sustainable transition and the digital transition. The study specifically considers sustainability goals in terms of the triple bottom line and digitalization as the adoption of Industry 4.0 (I4.0) technologies. The study aims to understand how the characteristics of Italian districts influence the choices related to the twin transition and how it affects textile industrial firms.

Design/methodology/approach
The author conducts a multiple-case study involving five firms of industrial textile district of Prato.

Findings
The results show the relationship between the characteristics of the district, such as fragmentation of the supply chain, lean manufacturing, territorial proximity and attachment to origins and traditions and the sustainable goals and I4.0 technologies adoption. Moreover, the study proposes a framework for twin transition. Market and technology drive the process in which sustainability represents the aim, I4.0 serves as enablers and the relevant outcome is the implementation of the business model innovation.

Practical implications
These findings offer valuable insights for textile firms, policymakers and stakeholders seeking to navigate the complexities of twin transition.

Originality/value
The study contributes to the broader topic of twin transition. In particular, it links the particular context represented by the industrial district in which the textile firms operate to their conduct, and the two interconnected and distinct processes, sustainable transition and digital transition, with the business model innovation topic.
Emerging from COVID-19: the perceptions of university students to part-time working and its impact on their transferable skill development
Authors: Evans Carl , Lean Jonathan , Sen Ali , Yusof Zatun Najahah 
Published: June 2024

PurposeThe purpose of this study is to examine university students’ behaviours and perceptions relating to part-time working, particularly the impact of external factors such as COVID-19, on their work activity.Design/methodology/approachA structured, online questionnaire was issued to Business Management students at a UK university. A total of 123 responses were received.FindingsThe study offers a unique insight into the effects of Covid-19 on students’ perceptions regarding part-time work.Research limitations/implicationsIt is important for universities to understand the motivations of students and their current circumstances, since these could affect students’ academic performance and wellbeing and well as their employability, and as a consequence, influence university policy.Originality/valueThe study offers a unique insight into the effects of prevailing external factors in particular Covid-19 on students’ perceptions regarding part-time work.