bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human papillomavirus in oropharyngeal squamous cell carcinomas in korea: Use of G1 cycle markers as new prognosticators
Authors: Park Weon Seo , Ryu Junsun , Cho Kwan Ho , Choi Moon Kyung , Moon Sung Ho , Yun Tak , Chun Byung–Sam , Lee Geon Kook , Ahn Hyun–Joo , Lee John H. , Vermeer Paola , Jung Yuh–Seog 
Published: November 2011

AbstractBackgroundHuman papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC) exhibits distinct patterns worldwide, but its prevalence has not been extensively evaluated in Korea. The E7 oncogene‐mediated carcinogenesis and its meaning are yet to be uncovered for oropharyngeal SCCs.MethodsIn a Korean oropharyngeal SCC cohort, epidemiological indicators, HPV, and G1 cell cycle marker expressions were correlated with survival.ResultsAmong 93 surgically treated patients with oropharyngeal SCCs, 49.5% were HPV+, which were significantly younger, and predominantly nonsmoking. They demonstrated better survival than HPV‐ (94% vs 60%). Patients who were HPV+ with oropharyngeal SCCs expressed higher p16, cyclin‐dependent kinase 4 (cdk4), and lower pRb. The p16 (hazard ratio [HR] 2.39), pRb (HR 2.13), and CCND1 (HR 2.09) correlated with survival. Notably, combined markers like p16/cdk4 ratio (HR 2.47) and cdk4+CCND1 sum (HR 2.65) were more significantly correlated.ConclusionIncidence of HPV‐related oropharyngeal SCC in Korea is similar to U.S.‐European data. HPV presence correlates with improved survival. Expression ratios of G1 markers may predict survival of oropharyngeal SCCs better than each marker alone. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Metastatic cutaneous squamous cell carcinoma shows frequent deletion in the protein tyrosine phosphatase receptor Type D gene
Authors: Lambert Sally R. , Harwood Catherine A. , Purdie Karin J. , Gulati Abha , Matin Rubeta N. , Romanowska Malgorzata , Cerio Rino , Kelsell David P. , Leigh Irene M. , Proby Charlotte M. 
Published: November 2011

AbstractCutaneous squamous cell carcinoma (cSCC) is the second most common form of nonmelanoma skin cancer (NMSC), and its incidence is increasing rapidly. Metastatic cSCC accounts for the majority of deaths associated with NMSC, but the genetic basis for cSCC progression remains poorly understood. A previous study identified small deletions (typically <1 Mb) in the protein tyrosine phosphatase receptor Type D (PTPRD) gene that segregated with more aggressive cSCC. To investigate the apparent association between deletion within PTPRD and cSCC metastasis, a series of 74 formalin‐fixed paraffin‐embedded tumors from 31 patients was analyzed using a custom Illumina 384 SNP microarray. Deletions were found in 37% of patients with metastatic cSCC and were strongly associated with metastatic tumors when compared to those that had not metastasized (p = 0.007). Subsequent mutation analysis revealed a higher mutation rate for PTPRD than has been reported in any other cancer type, with 37% of tumors harboring a somatic mutation. Conversely, bisulfite sequencing showed that methylation was not a mechanism of PTPRD disruption in cSCC. This is the first report to observe an association between deletion within PTPRD and metastatic disease and highlights the potential use of these deletions as a diagnostic biomarker for tumor progression. Combined with the high mutation rate observed in our study, PTPRD is one of the most commonly altered genes in cSCC and warrants further investigation to determine its significance for metastasis in other tumor types.
Notch1‐Snail1‐E‐cadherin pathway in metastatic hepatocellular carcinoma
Authors: Wang Xiao Qi , Zhang Wu , Lui Eric L.H. , Zhu Yongqiang , Lu Ping , Yu Xiaoming , Sun Jisan , Yang Sitian , Poon Ronnie T.P. , Fan Sheung Tat 
Published: November 2011

AbstractNotch signaling, a critical pathway for tissue development, also contributes to tumorigenesis in many cancers, but its pathological function in liver cancer is not well defined. In our study, Notch1 expression and its clinicopathological parameters were evaluated in 82 human hepatocellular carcinoma (HCC) patients. Plasmid‐based siNotch1 shRNA was transiently or stably transfected into metastatic HCC cells and subsequently evaluated for the effects on orthotopic liver tumor metastasis in a mouse model as well as the effects on downstream pathways. Aberrant high expression of Notch1 was significantly associated with metastatic disease parameters in HCC patients, such as tumor‐node‐metastasis Stages III–IV and tumor venous invasion. Knocking‐down Notch1 reduced cell motility in vitro and orthotopic tumor metastasis from the liver to the lung in vivo in a mouse model. In metastatic HCC cells, abnormal expression of Notch1 was associated with increased expression of Snail1 and repressed expression of E‐cadherin; the Notch1‐Snail1‐E‐cadherin association can also be found in HCC patient tumors. Inhibition of Notch1 by shRNA abolished Snail1 expression, which further resulted in the re‐establishment of repressed E‐cadherin in metastatic HCC cells. Thus, abnormal Notch1 expression was strongly associated with HCC metastatic disease, which might be mediated through the Notch1‐Snail1‐E‐cadherin pathway. Knock‐down of Notch1 reversed HCC tumor metastasis in a mouse model. Therefore, these data suggest that effective targeting of Notch signaling might also inhibit tumor metastasis.
Cigarette smoking and lung cancer—relative risk estimates for the major histological types from a pooled analysis of case–control studies
Authors: Pesch Beate , Kendzia Benjamin , Gustavsson Per , Jöckel Karl‐Heinz , Johnen Georg , Pohlabeln Hermann , Olsson Ann , Ahrens Wolfgang , Gross Isabelle Mercedes , Brüske Irene , Wichmann Heinz‐Erich , Merletti Franco , Richiardi Lorenzo , Simonato Lorenzo , Fortes Cristina , Siemiatycki Jack , Parent Marie‐Elise , Consonni Dario , Landi Maria Teresa , Caporaso Neil , Zaridze David , Cassidy Adrian , Szeszenia‐Dabrowska Neonila , Rudnai Peter , Lissowska Jolanta , Stücker Isabelle , Fabianova Eleonora , Dumitru Rodica Stanescu , Bencko Vladimir , Foretova Lenka , Janout Vladimir , Rudin Charles M. , Brennan Paul , Boffetta Paolo , Straif Kurt , Brüning Thomas 
Published: November 2011

AbstractLung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung cancer datasets ever assembled, we explored the impact of smoking on risks of the major cell types of lung cancer. This pooled analysis included 13,169 cases and 16,010 controls from Europe and Canada. Studies with population controls comprised 66.5% of the subjects. Adenocarcinoma (AdCa) was the most prevalent subtype in never smokers and in women. Squamous cell carcinoma (SqCC) predominated in male smokers. Age‐adjusted odds ratios (ORs) were estimated with logistic regression. ORs were elevated for all metrics of exposure to cigarette smoke and were higher for SqCC and small cell lung cancer (SCLC) than for AdCa. Current male smokers with an average daily dose of >30 cigarettes had ORs of 103.5 (95% confidence interval (CI): 74.8–143.2) for SqCC, 111.3 (95% CI: 69.8–177.5) for SCLC and 21.9 (95% CI: 16.6–29.0) for AdCa. In women, the corresponding ORs were 62.7 (95% CI: 31.5–124.6), 108.6 (95% CI: 50.7–232.8) and 16.8 (95% CI: 9.2–30.6), respectively. Although ORs started to decline soon after quitting, they did not fully return to the baseline risk of never smokers even 35 years after cessation. The major result that smoking exerted a steeper risk gradient on SqCC and SCLC than on AdCa is in line with previous population data and biological understanding of lung cancer development.
Comparison between TEWL and laser scanning microscopy measurements for the in vivo characterization of the human epidermal barrier
Authors: Vergou Theognosia , Schanzer Sabine , Richter Heike , Pels Ragna , Thiede Gisela , Patzelt Alexa , Meinke Martina C. , Sterry Wolfram , Fluhr Joachim W. , Lademann Jürgen 
Published: November 2011

AbstractThe analysis of the skin barrier properties is important in various fields of medical treatment and cosmetology. The development and improvement of topically applied substances require an objective analysis of the skin barrier characteristics. Transepidermal water loss (TEWL) measurement is the standard method to characterize epidermal barrier function. The most important disadvantage of this method though, is that it can be affected by different exogenous and endogenous factors, e.g. water content of the applied formulation and room temperature. In the present study, TEWL measurements are compared to laser scanning microscopic (LSM) measurements, concerning the use of these two methods for the non‐invasive in vivo characterization of the epidermal barrier function. The investigations were performed prior and subsequent to treatment of dry skin with a gel mixture, developed for skin treatment after radiotherapy for cancer. The present results indicate that in vivo laser scanning microscopy is an appropriate method for the characterization of the skin barrier structure without interference by external factors. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Two‐photon excited fluorescence lifetime measurements through a double‐clad photonic crystal fiber for tissue micro‐endoscopy
Authors: Knorr Florian , Yankelevich Diego R. , Liu Jing , Wachsmann‐Hogiu Sebastian , Marcu Laura 
Published: November 2011

AbstractThis paper presents an endoscopic configuration for measurements of tissue autofluorescence using two–photon excitation and time‐correlated single photon counting detection through a double‐clad photonic crystal fiber (DC‐PCF) without pre‐chirping of laser pulses. The instrument performance was evaluated by measurements of fluorescent standard dyes, biological fluorophores (collagen and elastin), and tissue specimens (muscle, cartilage, tendon). Current results demonstrate the ability of this system to accurately retrieve the fluorescence decay profile and lifetime of these samples. This simple setup, which offers larger penetration depth than one‐photon‐based techniques, may be combined with morphology‐yielding techniques such as photoacoustic and ultrasound imaging. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone
Authors: Harada Suguru , Mizoguchi Toshihide , Kobayashi Yasuhiro , Nakamichi Yuko , Takeda Satoshi , Sakai Sadaoki , Takahashi Fumiaki , Saito Hitoshi , Yasuda Hisataka , Udagawa Nobuyuki , Suda Tatsuo , Takahashi Naoyuki 
Published: November 2011

Abstract
Eldecalcitol (ED-71) is a new vitamin D3 derivative recently approved for the treatment of osteoporosis in Japan. Previous studies have shown that the daily administration of ED-71 increases bone mineral density (BMD) by suppressing bone resorption in various animal models. In this study, we examined how ED-71 suppresses bone resorption in vivo, by analyzing bone histomorphometry and ex vivo osteoclastogenesis assays. Daily administration of ED-71 (50 ng/kg body weight) to 8-week-old male mice for 2 and 4 weeks increased BMD in the femoral metaphysis without causing hypercalcemia. Bone and serum analyses revealed that ED-71 inhibited bone resorption and formation, indicating that the increase in BMD is the result of the suppression of bone resorption. This suppression was associated with a decrease in the number of osteoclasts in trabecular bone. We previously identified cell cycle-arrested receptor activator of NF-κB (RANK)-positive bone marrow cells as quiescent osteoclast precursors (QOPs) in vivo. Daily administration of ED-71 affected neither the number of RANK-positive cells in vivo nor the number of osteoclasts formed from QOPs in ex vivo cultures. In contrast, ED-71 suppressed the expression of RANK ligand (RANKL) mRNA in femurs. Immunohistochemical experiments also showed that the perimeter of the RANKL-positive cell surface around the trabecular bone was significantly reduced in ED-71-treated mice than in the control mice. ED-71 administration also increased BMD in 12-week-old ovariectomized mice, through the suppression of RANKL expression in the trabecular bone. These results suggest that the daily administration of ED-71 increases BMD by suppressing RANKL expression in trabecular bone in vivo. © 2012 American Society for Bone and Mineral Research
A new haplotype in BMP4 implicated in ossification of the posterior longitudinal ligament (OPLL) in a Chinese population
Authors: Ren Yuan , Feng Jie , Liu Zhi‐zhong , Wan Hong , Li Jun‐hua , Lin Xin 
Published: November 2011

AbstractPrevious genome‐wide microarray analysis of candidate genes involved in the ossification of the posterior longitudinal ligament (OPLL) of the spine resulted in the identification of a novel, clinically relevant gene encoding bone morphogenetic protein 4 (BMP4) but was defined only by its expression patterns. The complete genomic BMP4 coding DNA from 450 patients with OPLL and 550 matched controls were sequenced and compared. We identified 18 SNPs, among which the minor alleles of SNP8 (C>T; p < 0.001; OR: 1.58), SNP13 (rs17563C>T; p < 0.001; OR: 1.76), and SNP14 (rs76335800A>T; p < 0.001; OR: 1.68) were associated with OPLL. Logistic regression analysis showed that the additive model of SNP8 (p < 0.001; OR: 3.48), SNP13 (p < 0.001; OR: 2.22), and SNP14 (p < 0.001; OR: 1.99) retained statistical significance. Linkage disequilibrium (LD) analysis identified a 3‐kbp block of intense LD in BMP4 and 1 specific haplotype, TGGGCTT (p < 0.001, OR: 2.54), which was associated with OPLL‐associated risk alleles and increased severity of OPLL, as shown by the distribution of ossified vertebrae in patients with OPLL (p = 0.002). Novel mutations in the BMP4 gene and a specific haplotype TGGGCTT appear to contribute to the risk of developing OPLL. Also the severity of OPLL seems to be mediated predominantly by genetic variations in this specific BMP4 gene region, but might be associated with other certain clinical and demographic characteristics in the Chinese population studied. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:748–756, 2012
An Algorithm for the Analytic Network Process (ANP) Structure Design
Authors: Khademi Navid , Mohaymany Afshin S. , Shahi Jalil , Zerguini Seghir 
Published: November 2011

ABSTRACTThe present paper delineates a three‐step algorithm for the analytic network process (ANP) structure design. When defining the decision goal and the alternative set, one can use the three‐step algorithm proposed in this paper, first, to specify the decision criteria, and second, to outline the structure of the ANP problem. To ease the process of ANP structure design, we present two novel data structures: the multiple‐effect tree and the multiple‐criteria tree. The multiple‐effect tree helps explore the apparent consequences of a given event or state—known in this paper as the decision alternatives—whereas the multiple‐criteria tree is considered the missing link between the multiple‐effect tree and the ANP structure. Employing the approach presented in this paper will help detect any mistakes in the ANP structure design. A numerical example is provided in the final section of the paper to better articulate the ideas. Copyright © 2011 John Wiley & Sons, Ltd.
Initial testing (stage 1) of SGI‐1776, a PIM1 kinase inhibitor, by the pediatric preclinical testing program
Authors: Batra Vandana , Maris John M. , Kang Min H. , Reynolds C. Patrick , Houghton Peter J. , Alexander Denise , Kolb E. Anders , Gorlick Richard , Keir Stephen T. , Carol Hernan , Lock Richard , Billups Catherine A. , Smith Malcolm A. 
Published: November 2011

AbstractThe PIM kinase inhibitor, SGI‐1776, was tested against the PPTP in vitro (1.0 nM–10 µM) and in vivo panels (148 mg/kg daily × 5 days for 3 weeks). SGI‐1776 exhibited cytotoxic activity in vitro with a median relative IC50 of 3.1 µM. SGI‐1776 induced significant differences in EFS distribution in vivo in 9 of 31 solid tumor xenografts and in 1 of 8 of the evaluable ALL xenografts. SGI‐1776 induced tumor growth inhibition meeting criteria for intermediate EFS T/C activity in 1 of 39 evaluable models. In contrast, SGI‐1776 induced complete responses of subcutaneous MV4;11 (B myeloid leukemia). Pediatr Blood Cancer 2012;59:749–752. © 2011 Wiley Periodicals, Inc.
Sorafenib as treatment for relapsed or refractory pediatric acute myelogenous leukemia
Authors: Watt Tanya C. , Cooper Todd 
Published: November 2011

AbstractThe prognosis for children with acute myelogenous leukemia (AML) has improved with overall survival rates of up to 65% [Pui et al. J Clin Oncol 2011; 29: 551–565]. However, the cure rate for AML lags behind that of acute lymphoblastic leukemia. Advances in AML leukemogenesis are leading to refined risk stratification. FMS like tyrosine kinase 3 (FLT3) mutations are independently associated with a poor prognosis. Newer kinase inhibitors, including sorafenib, have shown promise in adult studies. We report three pediatric patients with relapsed AML who achieved a sustained remission with sorafenib. Further trials are necessary to understand the role of sorafenib in pediatric AML. Pediatr Blood Cancer 2012;59:756–757. © 2011 Wiley Periodicals, Inc.
Nonvisualization of fetal gallbladder increases the risk of cystic fibrosis
Authors: Duguépéroux Ingrid , Scotet Virginie , Audrézet Marie‐Pierre , Saliou Anne‐Hélène , Collet Michel , Blayau Martine , Schmitt Sébastien , Kitzis Alain , Fresquet Fleur , Müller Françoise , Férec Claude 
Published: November 2011

ABSTRACTObjectiveThe aim of our study is to evaluate the prevalence of cystic fibrosis (CF) in fetuses referred for genetic testing because of ultrasonographic sign (nonvisualized fetal gallbladder – NVFGB).MethodWe reviewed the results of CFTR gene analysis over the period 2002 to 2009 in all consecutive cases referred because of NVFGB in Western France. We correlated these data with the presence of a more classical ultrasonographic finding (fetal echogenic bowel – FEB).ResultsCystic fibrosis was diagnosed in 5 of the 37 fetuses with NVFGB (13.5%, 95% confidence interval (CI): [2.5%; 24.5%]) and in only 9 of the 229 other cases referred because of FEB (3.9%, 95% CI: [3.2%; 14.7%]). In our series, all CF‐affected fetuses with NVFGB also had FEB. The risk of CF was 11.6‐fold higher in fetuses with both indications (NVFGB + FEB) than in fetuses with isolated FEB (45.5% vs 3.9%, RR = 11.6, 95% CI: [4.7%; 28.8%], p = 0.0001). We also estimated that the residual risk of CF was less than 1 in 68 (1.5%) when a single mutation was identified in the fetus by our molecular protocol.ConclusionUltrasonographic evidence of NVFGB is an additional risk factor for CF in cases with FEB. © 2011 John Wiley & Sons, Ltd.
Relationships between social support sources and early adolescents' mental health: The moderating effect of student achievement level
Authors: Stewart Tiffany , Suldo Shannon 
Published: November 2011

AbstractThis study examined how perceived social support from parents, classmates, and teachers jointly and uniquely predicted psychopathology (i.e., internalizing and externalizing symptoms) and wellness (i.e., life satisfaction) in a sample of 390 middle‐school students. This study also explored the protective nature of high student academic achievement in the relationship between social support and mental health. Social support was a significant predictor of all mental health outcomes, particularly life satisfaction. Although classmate and teacher support were significant unique predictors of students' internalizing and externalizing symptoms, respectively, parent support emerged as the strongest predictor of all indicators of mental health. Academic achievement moderated the direction and strength of the relationships between externalizing behavior and (a) classmate support, and (b) parent support, respectively. Specifically, classmate support emerged as adaptive for average‐ and high‐achieving students only, whereas academic achievement functioned as a protective factor against the manifestation of externalizing psychopathology among students with low parental support. Implications for school psychologists and directions for future research are discussed. © 2011 Wiley Periodicals, Inc.
Rural Poverty Dynamics and Refugee Communities in South Africa: A Spatial–Temporal Model
Authors: Sartorius Kurt , Sartorius Benn , Tollman Stephen , Schatz Enid , Kirsten Johann , Collinson Mark 
Published: November 2011

ABSTRACTThe assimilation of refugees into their host community economic structures is often problematic. The paper investigates the ability of refugees in rural South Africa to accumulate assets over time relative to their host community. Bayesian spatial–temporal modelling was employed to analyse a longitudinal database that indicated that the asset accumulation rate of former Mozambican refugee households was similar to their host community; however, they were unable to close the wealth gap. A series of geo‐statistical wealth maps illustrate that there is a spatial element to the higher levels of absolute poverty in the former refugee villages. The primary reason for this is their physical location in drier conditions that are established further away from facilities and infrastructure. Neighbouring South African villages in close proximity, however, display lower levels of absolute poverty, suggesting that the spatial location of the refugees only partially explains their disadvantaged situation. In this regard, the results indicate that the wealth of former refugee households continues to be more compromised by higher mortality levels, poorer education, and less access to high‐return employment opportunities. The long‐term impact of low initial asset status appears to be perpetuated in this instance by difficulties in obtaining legal status in order to access state pensions, facilities, and opportunities. The usefulness of the results is that they can be used to sharpen the targeting of differentiated policy in a given geographical area for refugee communities in rural Africa. Copyright © 2011 John Wiley & Sons, Ltd.
Technology and Corporate Scope: Firm and Rival Innovation as Antecedents of Corporate Transactions
Authors: Kaul Aseem 
Published: November 2011

AbstractThis paper studies the role of technological innovation as an antecedent of changes in corporate scope. It argues that technological innovations prompt the firm to reconfigure its corporate portfolio—to redeploy resources to areas of new opportunity while it divests out of marginal businesses. Results from a cross‐industry sample of U.S. manufacturing firms show successful innovation by a firm is followed by both expansion into new areas through complementary resource seeking acquisitions and divestment out of existing noncore businesses. This relationship is found to be moderated by the level of investible resources available to the firm, and supports the notion of scarce resources as a constraint on firm scope. In addition, firms are found to change their corporate scope in response to rival innovation. Copyright © 2011 John Wiley & Sons, Ltd.