bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determining the influence of belonging to a wine protected designation of origin on profitability
Authors: Moreno Gené Jordi , Solé Puiggené Sònia , Gallizo Larraz José Luis 
Published: May 2024

AbstractTo guide consumers, wineries need credible attributes about the quality of their wines and its origin. In Spain, protected designations of origin (PDO) guarantee that the wine has been produced in a certain wine region in accordance with specific and officially regulated quality criteria thus providing elements of guarantee to the consumer. The objective of this work is to determine whether the belonging of a winery to a PDO is positively or negatively related to profitability. This analysis is important because based on its results, managers will have more knowledge to decide whether a winery is interested in joining the regional PDO or not. We performed an empirical study using a random‐effects generalized least squares regression analysis, with a sample of 1182 Spanish wineries, in which we determine the relation between belonging to eight of the major Spanish PDOs and winery profitability. The results show that wineries registered in these PDOs tend to have higher levels of profitability than wineries that have opted to remain outside, with these differences being significant in five of the eight PDOs analyzed. Additionally, the regression model reveals a positive relationship between PDO membership and winery profitability in six of the eight PDOs. Furthermore, the findings suggest that in some of these PDOs small wineries benefit the most from being part of a PDO due to their difficulties in having a recognized brand in the market, while belonging to a PDO seems to be less useful for large wineries that have greater resources to build their own quality brand. On the basis of these findings, the wineries now have more information to decide whether to stay in the PDO, join it, or focus exclusively on developing their own brands [EconLit Citations: L15, L66, Q13].
Tailoring the d‐band centers enables NiM alloy to be multifunctional site for tandem reductive amination
Authors: Gao Zhexi , Zhao Xinxin , Wu Huifang , Zhao Yang , Ma Haoran , Wang Qian , Li Dianqing , Feng Junting 
Published: May 2024

AbstractIntegrating multi‐step reactions through tandem catalysis offers potential for efficient chemical engineering processes, but designing an efficient tandem catalyst is challenging. Herein, we report tailoring the d‐band centers of Ni through alloying with a second metal (M = Fe/Co/Cu/Ga), which enables it to be multifunctional site for tandem reductive amination. A linear correlation of d‐band center with yield of primary amine product was observed. Density functional theory and experiments revealed the upshifted d‐band center strengthened the adsorption of Schiff base intermediate in advantageous di(C&N) mode, also narrowed the adsorption energy gap between NH3 and H2. Furthermore, the multifunctional nanoparticles provide a confined space with short diffusion pathway for NH3* and H* to timely react with Schiff base. As a result, the NiFe/AlOx with a d‐band center nearest to the Fermi level exhibited the highest primary amine yield of 96.2% with five consecutive reusability under extremely low H2 pressure, which is superior to other reported precious‐metal‐based catalysts.
Why religion and spirituality are important in human biological research
Authors: Lynn Christopher D. , Schell Lawrence M. 
Published: May 2024

AbstractThe study of human biology includes exploration of all the genetic and environmental influences on human variation and life history, including impacts of sociocultural and physical environments. Religious practice and spirituality may be one of these influences. There are more than 5.8 billion religiously affiliated adults and children, accounting for 84% of the world's 6.9 billion people. Furthermore, 70% of Americans consider themselves spiritual in some way, including 22% who do not consider themselves religious, and the numbers for Europe are lower but proportionally similar. Such a high rate of religious affiliation and spiritual belief suggests that religion and spirituality could be sociocultural influences on human variation, but human biologists have scarcely attended to their impacts, as indicated by the limited numbers of relevant articles in the two flagship human biology journals. In this article, we discuss why human biologists may have overlooked this important force for human variability and highlight foundational work from human biology and other disciplines that can give our colleagues directions forward. We review the impacts of religion and spirituality at population and individual levels and call for human biologists to attend to the many aspects of religion and spirituality that can impact human biology and are much more than simply influences of denominational affiliation.
Polygenic Risk Scores Validated in Patient‐Derived Cells Stratify for Mitochondrial Subtypes of Parkinson's Disease
Authors: Arena Giuseppe , Landoulsi Zied , Grossmann Dajana , Payne Thomas , Vitali Armelle , Delcambre Sylvie , Baron Alexandre , Antony Paul , Boussaad Ibrahim , Bobbili Dheeraj Reddy , Sreelatha Ashwin Ashok Kumar , Pavelka Lukas , J Diederich Nico , Klein Christine , Seibler Philip , Glaab Enrico , Foltynie Thomas , Bandmann Oliver , Sharma Manu , Krüger Rejko , May Patrick , Grünewald Anne ,   the NCER‐PD and COURAGE‐PD Consortia
Published: May 2024

ObjectiveThe aim of our study is to better understand the genetic architecture and pathological mechanisms underlying neurodegeneration in idiopathic Parkinson's disease (iPD). We hypothesized that a fraction of iPD patients may harbor a combination of common variants in nuclear‐encoded mitochondrial genes ultimately resulting in neurodegeneration.MethodsWe used mitochondria‐specific polygenic risk scores (mitoPRSs) and created pathway‐specific mitoPRSs using genotype data from different iPD case–control datasets worldwide, including the Luxembourg Parkinson's Study (412 iPD patients and 576 healthy controls) and COURAGE‐PD cohorts (7,270 iPD cases and 6,819 healthy controls). Cellular models from individuals stratified according to the most significant mitoPRS were subsequently used to characterize different aspects of mitochondrial function.ResultsCommon variants in genes regulating Oxidative Phosphorylation (OXPHOS‐PRS) were significantly associated with a higher PD risk in independent cohorts (Luxembourg Parkinson's Study odds ratio, OR = 1.31[1.14–1.50], p‐value = 5.4e‐04; COURAGE‐PD OR = 1.23[1.18–1.27], p‐value = 1.5e‐29). Functional analyses in fibroblasts and induced pluripotent stem cells‐derived neuronal progenitors revealed significant differences in mitochondrial respiration between iPD patients with high or low OXPHOS‐PRS (p‐values < 0.05). Clinically, iPD patients with high OXPHOS‐PRS have a significantly earlier age at disease onset compared to low‐risk patients (false discovery rate [FDR]‐adj p‐value = 0.015), similar to prototypic monogenic forms of PD. Finally, iPD patients with high OXPHOS‐PRS responded more effectively to treatment with mitochondrially active ursodeoxycholic acid.InterpretationOXPHOS‐PRS may provide a precision medicine tool to stratify iPD patients into a pathogenic subgroup genetically defined by specific mitochondrial impairment, making these individuals eligible for future intelligent clinical trial designs. ANN NEUROL 2024;96:133–149
Reconfiguring the Hydrogen Networks of Aqueous Electrolyte to Stabilize Iron Hexacyanoferrate for High‐Voltage pH‐Decoupled Cell
Authors: Xie Zi‐Long , Zhu Yunhai , Du Jia‐Yi , Yang Dong‐Yue , Zhang Ning , Sun Qi‐Qi , Huang Gang , Zhang Xin‐Bo 
Published: May 2024

AbstractPrussian blue analogs (PBAs) are promising insertion‐type cathode materials for different types of aqueous batteries, capable of accommodating metal or non‐metal ions. However, their practical application is hindered by their susceptibility to dissolution, which leads to a shortened lifespan. Herein, we have revealed that the dissolution of PBAs primarily originates from the locally elevated pH of electrolytes, which is caused by the proton co‐insertion during discharge. To address this issue, the water‐locking strategy has been implemented, which interrupts the generation and Grotthuss diffusion of protons by breaking the well‐connected hydrogen bonding network in aqueous electrolytes. As a result, the hybrid electrolyte enables the iron hexacyanoferrate to endure over 1000 cycles at a 1 C rate and supports a high‐voltage pH‐decoupled cell with an average voltage of 1.95 V. These findings provide insights for mitigating the dissolution of electrode materials, thereby enhancing the viability and performance of aqueous batteries.
2D Exfoliation Chemistry Towards Covalent Pseudo‐Layered Phosphate Framework Derived by Radical/Strain‐Synergistical Process
Authors: Gu Zhen‐Yi , Cao Jun‐Ming , Li Kai , Guo Jin‐Zhi , Wang Xiao‐Tong , Zheng Shuo‐Hang , Zhao Xin‐Xin , Li Bao , Li Shu‐Ying , Li Wen‐Liang , Wu Xing‐Long 
Published: May 2024

Abstract2D compounds exfoliated from weakly bonded bulk materials with van der Waals (vdW) interaction are easily accessible. However, the strong internal ionic/covalent bonding of most inorganic crystal frameworks greatly hinders 2D material exfoliation. Herein, we first proposed a radical/strain‐synergistic strategy to exfoliate non‐vdW interacting pseudo‐layered phosphate framework. Specifically, hydroxyl radicals (⋅OH) distort the covalent bond irreversibly, meanwhile, H2O molecules as solvents, further accelerating interlayered ionic bond breakage but mechanical expansion. The innovative 2D laminar NASICON‐type Na3V2(PO4)2O2F crystal, exfoliated by ⋅OH/H2O synergistic strategy, exhibits enhanced sodium‐ion storage capacity, high‐rate performance (85.7 mAh g−1 at 20 C), cyclic life (2300 cycles), and ion migration rates, compared with the bulk framework. Importantly, this chemical/physical dual driving technique realized the effective exfoliation for strongly coupled pseudo‐layered frameworks, which accelerates 2D functional material development.
Efficient Neutral H2O2 Electrosynthesis from Favorable Reaction Microenvironments via Porous Carbon Carrier Engineering
Authors: Jing Lingyan , Wang Wenyi , Tian Qiang , Kong Yan , Ye Xieshu , Yang Hengpan , Hu Qi , He Chuanxin 
Published: May 2024

AbstractThe efficient electrosynthesis of hydrogen peroxide (H2O2) via two‐electron oxygen reduction reaction (2e− ORR) in neutral media is undoubtedly a practical route, but the limited comprehension of electrocatalysts has hindered the system advancement. Herein, we present the design of model catalysts comprising mesoporous carbon spheres‐supported Pd nanoparticles for H2O2 electrosynthesis at near‐zero overpotential with approximately 95 % selectivity in a neutral electrolyte. Impressively, the optimized Pd/MCS‐8 electrocatalyst in a flow cell device achieves an exceptional H2O2 yield of 15.77 mol gcatalyst−1 h−1, generating a neutral H2O2 solution with an accumulated concentration of 6.43 wt %, a level sufficiently high for medical disinfection. Finite element simulation and experimental results suggest that mesoporous carbon carriers promote O2 enrichment and localized pH elevation, establishing a favorable microenvironment for 2e− ORR in neutral media. Density functional theory calculations reveal that the robust interaction between Pd nanoparticles and the carbon carriers optimized the adsorption of OOH* at the carbon edge, ensuring high active 2e− process. These findings offer new insights into carbon‐loaded electrocatalysts for efficient 2e− ORR in neutral media, emphasizing the role of carrier engineering in constructing favorable microenvironments and synergizing active sites.
Synthesis of Photoresponsive Fast Self‐healing Polyolefin Composites by Nickel‐Catalyzed Copolymerization of Ethylene and Lignin Cluster Monomers
Authors: Chen Jiawei , Chen Ao , Zou Chen , Chen Changle 
Published: May 2024

AbstractPolymers may suffer from sudden mechanical damages during long‐term use under various harsh operating environments. Rapid and real‐time self‐healing will extend their service life, which is particularly attractive in the context of circular economy. In this work, a lignin cluster polymerization strategy (LCPS) was designed to prepare a series of lignin functionalized polyolefin composites with excellent mechanical properties through nickel catalyzed copolymerization of ethylene and lignin cluster monomers. These composites can achieve rapid self‐healing within 30 seconds under a variety of extreme usage environments (underwater, seawater, extremely low temperatures as low as −60 °C, organic solvents, acid/alkali solvents, etc.), which is of great significance for real‐time self‐healing of sudden mechanical damage. More importantly, the dynamic cross‐linking network within these composites enable great re‐processability and amazing sealing performances.
Facile Access to Organostibines via Selective Organic Superbase Catalyzed Antimony‐Carbon Protonolysis
Authors: Culvyhouse Jacob , Unruh Daniel K. , Lischka Hans , Aquino Adelia J. A. , Krempner Clemens 
Published: May 2024

AbstractThe selective formation of antimony‐carbon bonds via organic superbase catalysis under metal‐ and salt‐free conditions is reported. This novel approach utilizes electron‐deficient stibine, Sb(C6F5)3, to give upon base‐catalyzed reactions with weakly acidic aromatic and heteroaromatic hydrocarbons access to a range of new aromatic and heteroaromatic stibines, respectively, with loss of C6HF5. Also, the significantly less electron‐deficient stibines, Ph2SbC6F5 and PhSb(C6F5)2 smoothly underwent base‐catalyzed exchange reactions with a range of terminal alkynes to generate the stibines of formulae PhSb(C≡CPh)2, and Ph2SbC≡CR [R=C6H5, C6H4‐NO2, COOEt, CH2Cl, CH2NEt2, CH2OSiMe3, Sb(C6H5)2], respectively. These formal substitution reactions proceed with high selectivity as only the C6F5 groups serve as a leaving group to be liberated as C6HF5 upon formal proton transfer from the alkyne. Kinetic studies of the base‐catalyzed reaction of Ph2SbC6F5 with phenyl acetylene to form Ph2SbC≡CPh and C6HF5 suggested the empirical rate law to exhibit a first‐order dependence with respect to the base catalyst, alkyne and stibine. DFT calculations support a pathway proceeding via a concerted σ‐bond metathesis transition state, where the base catalyst activates the Sb‐C6F5 bond sequence through secondary bond interactions.
piSTING: A Pocket‐Independent Agonist Based on Multivalency‐Driven STING Oligomerization
Authors: Zhuo Shao‐Hua , Wang Tian‐Yang , Zhao Lang , Su Jing‐Yun , Hu Jin‐Jian , Zhao Yu‐Fen , Li Yan‐Mei 
Published: May 2024

AbstractThe stimulator of interferon genes (STING) pathway is a potent therapeutic target for innate immunity. Despite the efforts to develop pocket‐dependent small‐molecule STING agonists that mimic the endogenous STING ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), most of these agonists showed disappointing results in clinical trials owing to the limitations of the STING pocket. In this study, we developed novel pocket‐independent STING‐activating agonists (piSTINGs), which act through multivalency‐driven oligomerization to activate STING. Additionally, a piSTING‐adjuvanted vaccine elicited a significant antibody response and inhibited tumour growth in therapeutic models. Moreover, a piSTING‐based vaccine combination with aPD‐1 showed remarkable potential to enhance the effectiveness of immune checkpoint blockade (ICB) immunotherapy. In particular, piSTING can strengthen the impact of STING pathway in immunotherapy and accelerate the clinical translation of STING agonists.
Evaluation of novel urethane dimethacrylates as crosslinkers for the development of fracture tough dental materials containing a poly(ε‐caprolactone)‐polydimethylsiloxane‐poly(ε‐caprolactone) triblock copolymer
Authors: Ott Erwan , Fässler Pascal , Grob Benjamin , Rist Kai , Vidal Loïc , Lalevée Jacques , Catel Yohann 
Published: May 2024

AbstractPhotocuring 3D printing of materials exhibiting high fracture toughness and excellent mechanical properties (flexural strength/modulus) is challenging. Nowadays, most of the photocurable 3D printing resins are based on a mixture of multifunctional (meth)acrylates and provide therefore brittle materials. This article describes further developments of a toughening strategy based on the incorporation of block copolymers in low crosslink density methacrylate‐based materials. Six dimethacrylates bearing a bisphenol A core and urethane groups are successfully synthesized. Various spacers between the bisphenol A core and the methacrylate groups are selected. Each monomer is combined with (octahydro‐4,7‐methano‐1H‐indenyl)methyl acrylate as a monofunctional monomer and a poly(ε‐caprolactone)‐polydimethylsiloxane‐poly(ε‐caprolactone) triblock copolymer is added as toughener. It is shown that the addition of the triblock copolymer results for all mixtures in a strong increase of the fracture toughness. Moreover, the higher the amount of monofunctional monomer, the stronger the increase. The nature of the urethane dimethacrylate is found to have a significant influence on the fracture toughness, flexural strength, and flexural modulus of cured materials. Two of the synthesized dimethacrylates are identified as promising candidates for the development of fracture‐tough photocuring 3D printing materials.
Board committees as catalysts: Divulging the impact of nomination and risk management on corporate eco‐innovation and carbon performance
Authors: Zaid Mohammad A. A. , Issa Ayman 
Published: May 2024

AbstractDrawing on a theoretical integration perspective, this research responds to the latest calls in sustainability accounting by comprehensively exploring the moderating roles of two board sub‐committees: the nomination committee and the risk management committee, in the relationship between corporate eco‐innovation and carbon performance. This study contributes to the current literature in sustainability accounting by utilizing panel data from non‐financial listed firms on the Australian Securities Exchange (ASX) for the period spanning from 2011 to 2022. To mitigate potential endogeneity bias, various econometric techniques, including instrumental variable modeling, were employed. The robust findings confirm a positive and statistically significant relationship between eco‐innovation and carbon emissions reduction. Moreover, both the nomination committee and the risk management committee emerge as significant moderators of this relationship. These empirical findings hold valuable practical, theoretical, and policy implications for diverse stakeholders seeking a comprehensive understanding of the role of board sub‐committees as effective monitoring tools that support corporate carbon performance by encouraging firms to actively embrace eco‐innovation practices. As a result, our evidence underscores the significance of giving due attention to board sub‐committees when configuring the board's structure and setting expectations for carbon reduction performance.
Effect of culture hydrodynamics on Arthrospira platensis production using a single‐use photobioreactor system through a CFD supported approach
Authors: Demirden S. Furkan , Erdogan Barıs , Öncel Deniz Şenyay , Oncel Suphi S. 
Published: May 2024

AbstractLaboratory scale conventional single‐use bioreactor was used to investigate the effect of different stirrer speeds on the Arthrospira platensis (Spirulina platensis) culture. Experiments were handled in two steps. First step was the selection of the stirring speeds, which was simulated via using CFD, and the second was the long term cultivation with the selected speed. During 10 days of batches as the first step, under identical culture conditions, stirrer speed of 230 rpm gave higher results, compared to 130 and 70 rpm, with respect to dry biomass weight, absorbance value (AB) and chlorophyll‐a concentration. Volumetric productivity during the growth phase of the cultures were calculated as 0.39 ± 0.03, 0.28 ± 0.01, and 0.19 ± 0.02 g L−1 d−1, from the fast to the slower speeds. According to the results a 17 day batch was handled with 230 rpm in order to monitor the effects on the culture. The culture reached a volumetric productivity of 0.33 ± 0.04 g L−1 d−1. Statistical analysis showed the significance of the parameters related with the stirring speed.
Exploring intercultural sensitivity in bicultural and multicultural Reddit users: The role of both identity (or individual) and contextual (or social) factors
Authors: Mancini Tiziana , Imperato Chiara 
Published: May 2024

AbstractThe Internet has revolutionized communication, enabling interactions between individuals from diverse cultures. This is especially true for social media which encourages participation in millions of online communities on a wide range of topics, such as Reddit. Research has largely neglected the intricate relationship between new media and intercultural issues. This study aims to address this gap by exploring the use experience of bicultural and multicultural individuals on Reddit and investigating the impact of identity‐level (identity categorization, compartmentalization, and integration) and contextual‐level (identification with the online network, online intergroup contact frequency and quality) factors on intercultural sensitivity. A sample of 241 bicultural (n = 90) and multicultural (n = 151) Reddit users (females = 100, 41.49%) participated in the study. Hierarchical regression results showed that both identity‐level and contextual‐level factors significantly contributed to intercultural sensitivity. Specifically, on the identity‐level, integration was positively related to intercultural sensitivity, while compartmentalization was negatively associated with it. Additionally, on the contextual‐level, identification with the online network and high‐quality online intergroup contact were associated with greater intercultural sensitivity. This research highlights the importance of understanding how intercultural dynamics unfold within social media platforms and provides insights for fostering intercultural sensitivity in online communities.
Biomimetic Chemical Reactions with Natural Products Using Metalloporphyrins and Salen Complexes as Catalysts: A Brief Review
Authors: Sousa Rita C. N. , Confessor Vitor P. P. , Da Silva Antonio K. B. , Almeida Addison R. , Pinheiro Francisco A. S. D. , Ferreira Leandro S. 
Published: May 2024

AbstractThe cytochrome P450 is a superfamily of hemoproteins mainly present in the liver and are versatile biocatalysts. They participate in the primary metabolism and biosynthesis of various secondary metabolites. Chemical catalysts are utilized to replicate the activities of enzymes. Metalloporphyrins and Salen complexes can contribute to the products’ characterization and elucidate biotransformation processes, which are investigated during pre‐clinical trials. These catalysts also help discover biologically active compounds and get better yields of products of industrial interest. This review aims to investigate which natural product classes are being investigated by biomimetic chemical models and the functionalities applied in the use of these catalysts. A limited number of studies were observed, with terpenes and alkaloids being the most investigated natural product classes. The research also revealed that Metalloporphyrins are still the most popular in the studies, and the identity and yield of the products obtained depend on the reaction system conditions.