bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper in Household Drinking Water in the City of Zagreb, Croatia
Authors: Pizent Alica , Butković Sanja 
Published: September 2010

Copper in Household Drinking Water in the City of Zagreb, CroatiaCopper concentration was estimated in tap water samples obtained from 70 households in Zagreb, serviced by a public water supply system. First-draw and flushed samples of tap water were collected in the morning and total copper concentration was determined by graphite furnace atomic absorption spectrometry with Zeeman-effect background correction. We also estimated the contribution of plumbing material to copper concentrations in tap water. In households with copper pipes, median and range copper values were 310 μg L-1 [(27 to 632) μg L-1] in first-draw samples and 16 μg L-1 [(5 to 52) μg L-1] in flushed samples. Corresponding values for households with galvanised pipes were 140 μg L-1 [(11 to 289) μg L-1] and 8 μg L-1 [(1 to 42) μg L-1], respectively. Copper concentrations in household tap water in Zagreb were far below the proposed safe limits set by the Croatian and WHO regulations and EPA standards, and drinking water in Zagreb is not a significant source of copper exposure.
Effect of Copper on the Toxicity and Genotoxicity of Cadmium in Duckweed (Lemna Minor L.)
Authors: Cvjetko Petra , Tolić Sonja , Šikić Sandra , Balen Biljana , Tkalec Mirta , Vidaković-Cifrek Željka , Pavlica Mirjana 
Published: September 2010

Effect of Copper on the Toxicity and Genotoxicity of Cadmium in Duckweed (Lemna Minor L.)We investigated interactions between copper (in the concentrations of 2.5 μmol L-1 and 5 μmol L-1) and cadmium (5 μmol L-1) in common duckweed (Lemna minor L.) by exposing it to either metal or to their combinations for four or seven days. Their uptake increased with time, but it was lower in plants treated with combinations of metals than in plants treated with either metal given alone. In separate treatments, either metal increased malondialdehyde (MDA) level and catalase and peroxidase activity. Both induced DNA damage, but copper did it only after 7 days of treatment. On day 4, the combination of cadmium and 5 μmol L-1 copper additionally increased MDA as well as catalase and peroxidase activity. In contrast, on day 7, MDA dropped in plants treated with combinations of metals, and especially with 2.5 μmol L-1 copper plus cadmium. In these plants, catalase activity was higher than in copper treated plants. Peroxidase activity increased after treatment with cadmium and 2.5 μmol L-1 copper but decreased in plants treated with cadmium and 5 μmol L-1 copper. Compared to copper alone, combinations of metals enhanced DNA damage after 4 days of treatment but it dropped on day 7. In conclusion, either metal given alone was toxic/genotoxic and caused oxidative stress. On day 4 of combined treatment, the higher copper concentration was more toxic than either metal alone. In contrast, on day 7 of combined treatment, the lower copper concentration showed lower oxidative and DNA damage. These complex interactions can not be explained by simple antagonism and/or synergism. Further studies should go in that direction.
A functional analysis of G23A polymorphism and the alternative splicing in the expression of the XPA gene
Authors: Butkiewicz Dorota , Krześniak Małgorzata , Vaitiekunaite Rasa , Sikora Bożena , Bowman Elise , Harris Curtis , Rusin Marek 
Published: September 2010

AbstractThe XPA gene has a commonly occurring polymorphism (G23A) associated with cancer risk. This study assessed the functional significance of this polymorphism, which is localised near the translation start codon. Lymphoblastoid cell lines with alternative homozygous genotypes showed no significant differences in their XPA levels. The luciferase reporter assay detected no functional difference between the two sequences. Unexpectedly, we found that the alternatively spliced form of XPA mRNA lacked a part of exon 1. Only the reading frame downstream of codon Met59 was preserved. The alternative mRNA is expressed in various human tissues. The analysis of the 5’cDNA ends showed similar transcription start sites for the two forms. The in vitro expression of the alternative XPA labelled with the red fluorescent protein (mRFP) showed a lack of preferential nuclear accumulation of the XPA isoform. The biological role of the alternative XPA mRNA form remains to be elucidated.
EFOMP project on the role of biomedical physics in the education of healthcare professionals
Authors: Caruana Carmel , Wasilewska-Radwanska M. , Aurengo A. , Dendy P. , Karenauskaite V. , Malisan M. , Meijer J. , Mornstein V. , Rokita E. , Vano E. , Wucherer M. 
Published: September 2010

EFOMP project on the role of biomedical physics in the education of healthcare professionals
The policy statements describing the role of the medical physicist (and engineer) published by organizations representing medical physics (and engineering) in Europe include the responsibility of providing a contribution to the education of healthcare professionals (physicians and paramedical professions). As a consequence, medical physicists and engineers provide educational services in most Faculties of Medicine / Health Science in Europe. In 2005, the EFOMP council took the decision to set up a Special Interest Group to develop the role of the medical physics educator in such faculties and to work with other healthcare professional groups to produce updated European curricula for them. The effort of the group would provide a base for the progress of the role, its relevance to contemporary healthcare professional education and provide input for future EFOMP policy documents regarding this important aspect of the role of the medical physicist. The present communication will present the group, summarise its latest research and indicate future research directions.
The design of an insulin pump - preliminary requirements (a technical note)
Authors: Hawlas Hubert , Lewenstein Krzysztof 
Published: September 2010

The design of an insulin pump - preliminary requirements (a technical note)
The material presented in this paper is an attempt to lay down requirements for the planned design of an insulin pump. An insulin pump is a device for continuous dosage of insulin at a selected rate, which facilitates treatment and improves the lives of diabetic patients. This paper is a compilation of medical requirements and user suggestions of presently offered insulin pumps.
It seems important to establish proper requirements for a device before starting developing any design for an insulin pump.
A virtual model of the patient's head for BNCT
Authors: Tyminska Katarzyna , Jezierski Karol , Osko Jakub 
Published: September 2010

A virtual model of the patient's head for BNCT
The aim of the present work was creating a virtual phantom of a human head for BNCT, as a part of the BNCT programme project. This model is an amplification of the simple model described in earlier publications. It takes into account the major head organs as well as the scalp and skull. The chemical composition of all tissues was modelled according to the recommendations of the ICRP. The organs were parameterized using mathematical formulas based on the human head magnetic resonance images. The model was used for calculating the thermal neutron flux and the injuring (fast neutron, nitrogen and gamma) dose components for the head irradiated using the therapeutic neutron beam, whose parameters were obtained as the result of the modelling of the filter/moderator system for the BNCT therapeutic beam from the MARIA reactor.
Mobile phones and hearing - A review
Authors: Lakshmanagowda Preethi , Supe Sanjay , Viswanath Lokesh , Kunjar Sathish 
Published: September 2010

Mobile phones and hearing - A review
Mobile phones are being widely used throughout the world. Although there is no clear evidence of harmful effects of radiofrequency (RF) radiation at the levels used by these devices, there is widespread public concern that there may be potential for harm. Of all anatomical structures, the ear is closest to the mobile phone, which may lead to relatively high energy deposition in the ear compared to other parts of the body. Till the year 2000 only a few studies had addressed potential adverse effects of EMFs on the hearing system. The potential adverse effects of mobile phone exposure on the hearing system should be investigated, because mobile phones are usually held close to the ear. Until now, most studies have assessed the influence of RF radiation on the central or peripheral auditory system. However, clear conclusions cannot be drawn from these studies regarding the presence or absence of effects because of the limitations in the audiological and/or dosimetric approaches and limited sample sizes. results. Although the presence of possible effects on hearing threshold levels cannot be dismissed entirely, the evidence available is not sufficiently strong to conclude that there are adverse effects. A replication study with a shift in hearing threshold levels at high frequencies as the a priori hypothesis is desirable to resolve this issue.
Numerical Modelling of Airflow and Temperature Distribution in a Living Room with Different Heat Exchange Conditions
Authors: Gendelis S. , Jakovičs A. 
Published: September 2010

Numerical Modelling of Airflow and Temperature Distribution in a Living Room with Different Heat Exchange ConditionsNumerical mathematical modelling of the indoor thermal conditions and of the energy losses for separate rooms is an important part of the analysis of the heat-exchange balance and energy efficiency in buildings. The measurements of heat transfer coefficients for bounding structures, the air-tightness tests and thermographic diagnostics done for a building allow the influence of those factors to be predicted more correctly in developed numerical models. The temperature distribution and airflows in a typical room (along with the heat losses) were calculated for different heater locations and solar radiation (modelled as a heat source) through the window, as well as various pressure differences between the openings in opposite walls. The airflow velocities and indoor temperature, including its gradient, were also analysed as parameters of thermal comfort conditions. The results obtained show that all of the listed factors have an important influence on the formation of thermal comfort conditions and on the heat balance in a room.
The Hieroglyphic Luwian -si Again
Authors: Oshiro Terumasa 
Published: September 2010

The Hieroglyphic Luwian -siAgainWe recognize three attestations of the element -siattached to a verbal ending in KARKAMIŠ A11b, A12 and ALEPO 2. The author has already regarded this -sias another reflexive element comparable to the reflexive -ti. Furthermore, we can also point out four more attestations of a similar element -siin the inscriptions recently discovered at TELL AHMAR 6:huhasata-si"he himself ran" (vii and xix) and at ÇINEKÖY:iziya-si"they themselves made" (vi and vii). It should be noted that the element -siin ÇINEKÖY is attached directly to an irregularly omitted verbal formiziyaof *iziyanta"they made".
Tumor Necrosis Factor Alpha Inhibits Olfactory Regeneration in a Transgenic Model of Chronic Rhinosinusitis–Associated Olfactory Loss
Authors: Turner Justin H. , Liang Kai Li , May Lindsey , Lane Andrew P. 
Published: September 2010

Background Olfactory loss is a debilitating symptom of chronic rhinosinusitis (CRS). Although olfactory sensory neurons (OSNs) are normally regenerated constantly in the olfactory epithelium (OE), a transgenic model of CRS-associated olfactory loss (inducible olfactory inflammation [IOI] mouse) shows that inflammation causes widespread OSN loss without progenitor cell proliferation. In this study, we further examine whether the inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) inhibits olfactory regeneration. Methods IOI mice underwent either unilateral bulbectomy or sham surgery and then were induced to express TNF-alpha in the OE for 1 week. After death, the mice were assessed histologically and with bromodeoxyuridine staining to determine the effect of TNF-alpha on olfactory regeneration. Results In the absence of TNF-alpha, bulbectomy was associated with death of OSNs, followed by robust proliferation of neural progenitors and regrowth of the OE. At 12 days postbulbectomy, OE thickness on the operated side had recovered to >80% of the unoperated side. In mice in which TNF-alpha expression was induced, significantly reduced proliferation was observed, associated with failure of normal reconstitution of OE thickness. Conclusion The mechanism of olfactory dysfunction in CRS remains incompletely understood. Previous studies with a transgenic mouse model suggested that inflammation inhibits progenitor cell proliferation and olfactory regeneration. Here, the role of the CRS-associated cytokine TNF-alpha was investigated using surgical ablation of the olfactory bulb to stimulate synchronous OSN turnover. We find that TNF-alpha expression prevents normal OE recovery, supporting the role of suppressed olfactory regeneration in the pathophysiology of CRS-associated olfactory loss.
Aberrant Mucin Glycoprotein Patterns of Chronic Rhinosinusitis Patients with Bacterial Biofilms
Authors: Tan Lorwai , Psaltis Alkis , Baker Leonie M. , McGuckin Mike , Rousseau Karine , Wormald Peter-John 
Published: September 2010

Background Increasingly bacterial biofilms have been implicated in chronic rhinosinusitis (CRS), and conventional treatment methods have failed to completely eradicate biofilms. (1) Terminal sialic acids present on sinus mucosal glycoproteins are targets for bacterial adherence and biofilm formation. (2) A subpopulation of CRS patients is more susceptible to biofilm formation due to aberrant terminal sialic residue distribution patterns of glycoproteins on their mucosa. (3) The higher levels of sialyl transferase (ST)6Gal1 gene expression contribute to the overall aberrant glycosylation patterns on the host mucosa that predispose this patient cohort to developing biofilms. (4) Mucin glycoprotein MUC7 that has known bactericidal activity displays an overall reduced terminal sugar profile in biofilm positive CRS patients. Methods Confocal scanning laser microscopy, glycoarray analysis, real-time polymerase chain reaction of ST6Gal1, neuraminidase assays and multivariate analysis were used to compare production of sialic acid–degrading enzymes in sinus biopsies from biofilm positive and negative CRS patients with mucosa from healthy controls. Results Biofilm-positive CRS patients expressed aberrant glycoprotein patterns with terminal sialics of between 70 and 90 kD (stress value = 0.1414). The ST6Gal1 gene was upregulated, and bacteria isolated from these patients exhibit significantly higher neuraminidase activity (p = 0.0343). We detected a significant lack in the overall expression of terminal sugar residues of MUC7 (stress value = 0.088). Conclusions We observed a strong positive correlation between the aberrant terminal sugar patterns in this sub group of CRS patients with biofilms. The innate immunity function of their MUC7 glycoprotein against bacterial invasion may be compromised in CRS patients.
Olfactory Event–Related Potential in Patients with Rhinosinusitis-Induced Olfactory Dysfunction
Authors: Hu Bin , Han Demin , Zhang Luo , Li Yunchuan , Zang Hongrui , Wang Tong , Xian Mu , Zhang Wei , Yang Ling , Wang Hong , He Fei 
Published: September 2010

Background Olfactory disorders are a common syndrome in the rhinology clinic. Olfactory event–related potential (OERP) has been considered as an important alternative method to evaluate olfactory function. The aim of this study was to find the consistency of OERP and the psychophysics olfactory test (T&T olfactometry assessment) in rhinosinusitis patients with or without nasal polyposis. Methods Both the psychophysics olfactory test and the OERP were performed in all patients before functional endoscopic sinus surgery (FESS). Detailed information including demographic, comorbidity, subjective symptoms, CT, and endoscopic examination were recorded. Six months later, the T&T test and OERP were reexamined in patients with preoperative identified OERP. Results Preoperative OERP was identified in 26 patients of the nonpolyp group and 12 patients of the polyp group. Good correlation existed between T&T scores and amplitude and latency of N1 and P2 in 26 nonpolyp patients (p < 0.05). No meaningful correlation was apparent in 12 polyp patients (p > 0.05). Significant correlation existed in 7 polyp patients with a free olfactory cleft (OC) according to CT (p < 0.05). The other 5 patients with partial OC obstruction were anosmic according to the psychophysics olfactory test; however, OERP was present. Six months later, T&T scores decreased significantly only in these five patients (p < 0.05). Significant correlation was obtained between postoperative T&T scores and OERP in both polyp and nonpolyp groups (p < 0.05). Conclusion OERP can be used to investigate olfactory function of rhinosinusitis patients. Nasal polyp obstruction in specific parts of the OC might influence the consistency between the psychophysics olfactory test and OERP.
Exercise-Induced Rhinitis in Competitive Swimmers
Authors: Alves Ana , Martins Carla , Delgado Luís , Fonseca João , Moreira André 
Published: September 2010

Background Elite swimmers are at increased risk of asthma, which has been related to chronic effects of pool chlorine environment. However acute effects of swimming on rhinitis remain unknown. Objective We aimed to assess the nasal response to exercise in competitive swimmers compared with competitive runners. Methods Measurements of nasal symptoms, peak nasal inspiratory flow, lung function, dyspnea, and of airway inflammation were obtained before and after a training session of 19 international-level swimmers and 13 professional runners. Exercise-induced rhinitis was defined as a fall in peak nasal inspiratory flow above 20% from baseline and atopy by positivity to skin-prick testing. Changes within groups were compared using paired t test and differences compared by analysis of covariance. Results Prevalence of exercise-induced rhinitis was similar between swimmers and runners, respectively 21% and 23%. Contrary to runners, swimmers experienced a decrease in nasal inspiratory flow levels and increase in sneezing, nasal congestion, itching, and postnasal drip after exercise. However, difference in changes was only significant for postnasal drip (p = 0.050). All subjects experiencing exercise-induced rhinitis were nonatopic. An overall improvement in nasal flows, sneezing, and itching after exercise was observed in atopic athletes, although no significant differences in changes compared with nonatopic athletes existed. Conclusion Swimmers, contrary to runners, experience a worsening of nasal function after training. Although these differences were only significant for postnasal drip, our results provide support to the existence of a “swimming-induced rhinitis” independent of the atopic status of the athlete.
Dose levels from thoracic and pelvic examinations in two pediatric radiological departments in Norway – a comparison study of dose-area product and radiographic technique
Authors: Sæther Hilde Kjernlie , Lagesen Bente , Martinsen Anne Catrine Trægde , Holsen Eva Platou , Øvrebø Kirsti Marie 
Published: September 2010

Background: Pediatric doses expressed in dose-area product (DAP) can be retrieved from only a few publications; most of which correlate DAP to patient size or large age spans. In clinical practice age is often the only available parameter describing the patient, and thus, evaluation of dose levels in pediatric radiology on the basis of DAP related to age alone would be useful in optimization work. Purpose: To provide comparable data on age-related DAP from thoracic and pelvic radiological examinations of children, and evaluate the usefulness of comparing age-related DAP and radiographic technique between systems to identify areas with potential for optimization. Material and Methods: DAP, age, and radiographic technique were registered for 575 thoracic examinations and 371 pelvic examinations of children from newborn up to 14 years of age in groups with an age span of 1 year, performed with two digital flat-panel systems and one computed radiography system. Results: DAP varies from 2.2 to 54.0 mGycm2 for thoracic examinations, and from 4.6 to 532.5 mGycm2 for pelvic examinations. There are significant differences in DAP between systems and departments due to differences in technique, equipment, and staff. Conclusion: This study provides comparable data on age-related DAP from thoracic and pelvic radiological examinations of children, which could be used as an input to estimate diagnostic reference levels. The comparison between systems of DAP and radiographic technique has proven useful in identifying areas where there may be a potential for optimization.
Suicide Trends in an Expanding Mental Health Service in Auckland
Authors: Argyle Nick 
Published: September 2010

Objective: Suicide is a global health priority. It is important to analyse the effects of investment in mental health services on suicide rates. This paper presents and discusses recent changes in suicide rates and diagnostic mix among clients of the mental health service in Auckland during a time of service growth. Method: Details of suicides among current clients were analysed for the years 1993 to 2006, comparing the periods 1993–1999 and 2000–2006. These periods were compared with the local population and national figures. Results: The local population suicide rate decreased significantly with the rate among clients increasing slightly so the proportion occurring among clients increased (up to 31%). There was an increase in non-psychotic diagnoses. Conclusions: As access to services expands the proportion of suicides that occur in known clients will paradoxically increase. Service expansion may have contributed to the falling population suicide rate in Auckland.
Will a New Genotyping Test Help the Clinician Predict Response to Antidepressant Drugs?
Authors: Parker Gordon , Rowe Mark , Mehta Farzaan , Kumar Sonia 
Published: September 2010

Objective: The aim of this paper is to evaluate the accuracy of a new genotyping test (Antidepressant PredictAR) in assigning patients as likely ‘poor’, ‘rapid’ or ‘normal’ metabolizers of antidepressant drugs. Method: Eighty-nine patients were clinically assigned (on the basis of their historical response to antidepressant drugs) as ‘poor’, ‘rapid’ or ‘normal’ metabolizers and comparison was then made to their test-based 2D6 and C19 genotyping status reports. Results: The overall capacity of the test to allocate patients to four differing phenotypic categories reporting for the genotyping test was not significant in relation to either C19 or 2D6 analyses. However, the C19 test did appear to have some capacity to identify rapid metabolizers, and we note how we then sought to manage such patients clinically. Conclusions: The test may have some capacity to identify patients with a rapid metabolizing profile. Any further advantages were not identified by this study, whether reflecting methodological and/or assay limitations.