bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recanalization of port-superior mesenteric vein thrombosis with long-term anticoagulant therapy after failed early anticoagulant therapy
Authors: Okada Ichiro , Hagiwara Masahiro , Yoneyama Hisashi , Kohara Saeko , Shoji Yokobori 
Published: June 2024

Abstract
Background
Anticoagulant therapy with heparin is the first-line treatment for acute mesenteric vein thrombosis and is effective in improving outcomes. Conversely, patients with failed early anticoagulant therapy occasionally develop bowel infarction requiring surgery. The efficacy of long-term anticoagulant therapy on recanalizing mesenteric vein thrombosis in patients with failed early anticoagulant therapy remains unclear. Herein, we report a patient who achieved recanalization of port-superior mesenteric vein thrombosis treated with anticoagulant therapy for 10 years after failed early anticoagulant therapy, followed by bowel resection.

Case presentation
A 38-year-old male patient visited an outpatient clinic due to acute exacerbation of abdominal pain that had persisted for a month. He was diagnosed with port-superior mesenteric vein thrombosis on contrast-enhanced computed tomography (CT) scan and was transferred to our institution. Although he presented with abdominal pain, his respiration and circulation were stable upon hospital arrival. Anticoagulant therapy with heparin was started, and the patient was admitted to the intensive care unit. However, the patient’s abdominal pain worsened, and he began to develop signs of peritonitis. Repeat CT scan revealed bowel infarction. Thus, the patient underwent bowel resection 6 h after admission. The initial surgery was completed with open abdomen management. Bowel anastomosis was performed on the second-look surgery on the first postoperative day. Finally, the abdomen was closed on the third postoperative day after confirming the absence of bowel ischemia progression. The patient had prolonged impaired bowel function with paralytic ileus, but was discharged on the 60th postoperative day. He was then diagnosed with protein C and S deficiency based on the tests performed. Anticoagulant therapy with warfarin was initiated. He also received anticoagulant therapy in the outpatient setting. The patient’s port-superior mesenteric vein thrombosis had improved gradually with warfarin during the follow-up period. At 10 years after surgery, total occlusion of the port-superior mesenteric vein was recanalized with improvement of the portal collateral vessels. In addition, no gastric or esophageal varices were observed.

Conclusions
Long-term anticoagulation therapy could affect the recanalization of extensive thrombus in multiple segments in patients with mesenteric venous thrombosis.
Genome streamlining in Parcubacteria transitioning from soil to groundwater
Authors: Chaudhari Narendrakumar M. , Pérez-Carrascal Olga M. , Overholt Will A. , Totsche Kai U. , Küsel Kirsten 
Published: June 2024

Abstract
Background
To better understand the influence of habitat on the genetic content of bacteria, with a focus on members of Candidate Phyla Radiation (CPR) bacteria, we studied the effects of transitioning from soil via seepage waters to groundwater on genomic composition of ultra-small Parcubacteria, the dominating CPR class in seepage waters, using genome resolved metagenomics.

Results
Bacterial metagenome-assembled genomes (MAGs), (318 total, 32 of Parcubacteria) were generated from seepage waters and compared directly to groundwater counterparts. The estimated average genome sizes of members of major phyla Proteobacteria, Bacteroidota and Cand. Patescibacteria (Candidate Phyla Radiation – CPR bacteria) were significantly higher in soil-seepage water as compared to their groundwater counterparts. Seepage water Parcubacteria (Paceibacteria) exhibited 1.18-fold greater mean genome size and 2-fold lower mean proportion of pseudogenes than those in groundwater. Bacteroidota and Proteobacteria also showed a similar trend of reduced genomes in groundwater compared to seepage. While exploring gene loss and adaptive gains in closely related CPR lineages in groundwater, we identified a membrane protein, and a lipoglycopeptide resistance gene unique to a seepage Parcubacterium genome. A nitrite reductase gene was also identified and was unique to the groundwater Parcubacteria genomes, likely acquired from other planktonic microbes via horizontal gene transfer.

Conclusions
Overall, our data suggest that bacteria in seepage waters, including ultra-small Parcubacteria, have significantly larger genomes and higher metabolic enrichment than their groundwater counterparts, highlighting possible genome streamlining of the latter in response to habitat selection in an oligotrophic environment.
Modified frontal horn index: a novel risk predictor for sunken flap syndrome in the patients undergoing shunt procedures for post-decompressive craniectomy hydrocephalus
Authors: Yadav Vikrant , Sahu Anurag , Prasad Ravi Shankar , Pandey Nityanand , Mishra Manish Kumar , Pradhan Ravi Shekhar 
Published: June 2024

Abstract
Background
Decompressive craniectomy (DC) is a neurosurgical procedure, frequently used in lowering the refractory intracranial pressure (ICP) following traumatic brain injuries. Post-traumatic hydrocephalus (PTH), a debilitating complication in the patients with traumatic brain injuries, occurs in 11.9–36% patients undergoing DCs. Sunken flap syndrome (SFS) is a rare entity, following DCs or cerebrospinal fluid (CSF) diversion procedures for PTH after DCs and leads to neurological deterioration of the patients. Literature regarding risk factors associated with SFS in the patients undergoing ventriculoperitoneal shunt procedures for hydrocephalus following DCs is scarce. The aim of this study is to determine the incidence of SFS and to establish a relationship between several clinico-radiological features and SFS in patients undergoing shunt procedures for PTH.

Results
This retrospective study was conducted in a tertiary care trauma centre upon 60 patients who underwent shunt procedures for PTH. Intraventricular haemorrhage (P < 0.0001), communicating-type hydrocephalus (P = 0.0006), and modified frontal horn index (P < 0.0001) were significantly associated with development of SFS. MFHI > 43 was a significant risk factor in development of SFS.

Conclusions
SFS is the common complication following shunt procedures for PTH after DCs. MFHI is significant risk predictor for SFS. MFHI > 43 is associated with higher chances of developing SFS following shunt insertion in PTH. Early cranioplasty following DCs might prevent development of SFS.
Utility of transmanubrial osteomuscular sparing approach and its modification in vascular surgery: a case series study of surgeries related to subclavian artery
Authors: Itagaki Kota , Katahira Shintaro , Hosoyama Katsuhiro , Suzuki Yusuke , Niikawa Hiromichi , Otani Masayuki , Taketomi Ryuichi , Ito Koki , Takahashi Goro , Kumagai Kiichiro , Okada Yoshinori , Saiki Yoshikatsu 
Published: June 2024

Abstract
Background
The operative field in subclavian vessel surgery is limited by thoracic inlet and outlet structures. Although endovascular therapy for the subclavian artery could be an option, open repair management is occasionally required in cases of large aneurysms, infectious vasculopathy, and trauma. The transmanubrial osteomuscular sparing approach, commonly used in thoracic surgery area to resect superior sulcus tumors, is a simple and safe procedure providing an excellent view of the operative field. Herein, we present three cases that underwent open repair of the subclavian artery using the transmanubrial osteomuscular sparing approach, and we also highlight the utility of the technique along with the procedural details.

Case presentation
Case 1: A 54-year-old man presented with a true aneurysm of the proximal portion of the right subclavian artery. The aneurysm measured 50 × 80 mm and compressed the right lung and trachea. We performed an aneurysm resection and a right subclavian artery reconstruction via the transmanubrial osteomuscular sparing approach under cardiopulmonary bypass support.
Case 2: A 72-year-old man who presented with an abscess that formed around the left subclavian artery due to an unremoved guidewire during thoracic endovascular aortic repair for an aortic arch aneurysm in another hospital. After the antibiotics administration, debridement and axillary-axillary bypass were performed, and the guidewire was removed via a transmanubrial osteomuscular sparing approach with a use of cardiopulmonary bypass.
Case 3: A 60-year-old man presented with misplacement of an indwelling dialysis catheter inserted for acute renal failure and hyperkalemia. The catheter was placed through the right neck, but had penetrated the right internal jugular vein and was misplaced from the right subclavian artery into the proximal aortic arch. Emergently, we removed the catheter using the transmanubrial osteomuscular sparing approach.

Conclusions
The transmanubrial osteomuscular sparing approach to the subclavian artery provides an excellent view and a wide surgical field, even in different pathological situations. This is a simple, safe, and highly useful procedure and could be the standard approach for subclavian artery surgeries.
Prostate Cancer Risk Stratification by Digital Histopathology and Deep Learning
Authors: Shao Yanan , Bazargani Roozbeh , Karimi Davood , Wang Jane , Fazli Ladan , Goldenberg S. Larry , Gleave Martin E. , Black Peter C. , Bashashati Ali , Salcudean Septimiu 
Published: June 2024

PURPOSE Prostate cancer (PCa) represents a highly heterogeneous disease that requires tools to assess oncologic risk and guide patient management and treatment planning. Current models are based on various clinical and pathologic parameters including Gleason grading, which suffers from a high interobserver variability. In this study, we determine whether objective machine learning (ML)–driven histopathology image analysis would aid us in better risk stratification of PCa. MATERIALS AND METHODS We propose a deep learning, histopathology image–based risk stratification model that combines clinicopathologic data along with hematoxylin and eosin– and Ki-67–stained histopathology images. We train and test our model, using a five-fold cross-validation strategy, on a data set from 502 treatment-naïve PCa patients who underwent radical prostatectomy (RP) between 2000 and 2012. RESULTS We used the concordance index as a measure to evaluate the performance of various risk stratification models. Our risk stratification model on the basis of convolutional neural networks demonstrated superior performance compared with Gleason grading and the Cancer of the Prostate Risk Assessment Post-Surgical risk stratification models. Using our model, 3.9% of the low-risk patients were correctly reclassified to be high-risk and 21.3% of the high-risk patients were correctly reclassified as low-risk. CONCLUSION These findings highlight the importance of ML as an objective tool for histopathology image assessment and patient risk stratification. With further validation on large cohorts, the digital pathology risk classification we propose may be helpful in guiding administration of adjuvant therapy including radiotherapy after RP.
Safety, Efficacy, and Pharmacokinetics of SHR-A1811, a Human Epidermal Growth Factor Receptor 2–Directed Antibody-Drug Conjugate, in Human Epidermal Growth Factor Receptor 2–Expressing or Mutated Advanced Solid Tumors: A Global Phase I Trial
Authors: Yao Herui , Yan Min , Tong Zhongsheng , Wu Xinhong , Ryu Min-Hee , Park John J. , Kim Jee Hyun , Zhong Yahua , Zhao Yiming , Voskoboynik Mark , Yin Yongmei , Liu Kan , Kaubisch Andreas , Liu Caigang , Zhang Jian , Wang Shouman , Im Seock-Ah , Ganju Vinod , Barve Minal , Li Hui , Ye Changsheng , Roy Amitesh C. , Bai Li-Yuan , Yen Chia-Jui , Gu Shanzhi , Lin Yung-Chang , Wu Lingying , Bao Lequn , Zhao Kaijing , Shen Yu , Rong Shangyi , Zhu Xiaoyu , Song Erwei 
Published: June 2024

PURPOSE
SHR-A1811 is an antibody-drug conjugate composed of an anti–human epidermal growth factor receptor 2 (HER2) antibody trastuzumab, a cleavable linker, and a topoisomerase I inhibitor payload. We assessed the safety, tolerability, antitumor activity, and pharmacokinetics of SHR-A1811 in heavily pretreated HER2-expressing or mutated advanced solid tumors.

METHODS
This global, multi-center, first-in-human, phase I trial was conducted at 33 centers. Patients who had HER2-expressing or mutated unresectable, advanced, or metastatic solid tumors and were refractory or intolerant to standard therapies were enrolled. SHR-A1811 was administered intravenously at doses ranging from 1.0 to 8.0 mg/kg once every 3 weeks. The primary end points were dose-limiting toxicity, safety, and the recommended phase II dose.

RESULTS
From September 7, 2020, to February 27, 2023, 307 patients who had undergone a median of three (IQR, 2-5) previous treatment regimens in the metastatic setting received SHR-A1811 treatment. As of data cutoff (February 28, 2023), one patient from the 6.4 mg/kg group experienced dose-limiting toxicities (pancytopenia and colitis). The most common grade 3 or higher adverse events (AEs) included decreased neutrophil count (119 [38.8%]) and decreased WBC count (70 [22.8%]). Interstitial lung disease occurred in only eight (2.6%) patients. Serious AEs and deaths occurred in 70 (22.8%) and 13 (4.2%) patients, respectively. SHR-A1811 led to objective responses in 59.9% (184/307) of all patients, 76.3% (90/118) of HER2-positive breast cancer, 60.4% (55/91) of HER2 low-expressing breast cancer, and 45.9% (39/85 with evaluable tumor responses) of the 98 nonbreast tumors.

CONCLUSION
SHR-A1811 exhibited acceptable tolerability, promising antitumor activity, and a favorable pharmacokinetic profile in heavily pretreated advanced solid tumors. The recommended phase II dose of 4.8 or 6.4 mg/kg was selected for various tumor types.
Phase I Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced Melanoma
Authors: Hamid Omid , Lewis Karl D. , Weise Amy , McKean Meredith , Papadopoulos Kyriakos P. , Crown John , Kim Tae Min , Lee Dae Ho , Thomas Sajeve S. , Mehnert Janice , Kaczmar John , Lakhani Nehal J. , Kim Kevin B. , Middleton Mark R. , Rabinowits Guilherme , Spira Alexander I. , Yushak Melinda , Mehmi Inderjit , Fang Fang , Chen Shuquan , Mani Jayakumar , Jankovic Vladimir , Wang Fang , Fiaschi Nathalie , Brennan Laura , Paccaly Anne , Masinde Sheila , Salvati Mark , Fury Matthew G. , Kroog Glenn , Lowy Israel , Gullo Giuseppe 
Published: June 2024

PURPOSE Coblockade of lymphocyte activation gene-3 (LAG-3) and PD-1 receptors could provide significant clinical benefit for patients with advanced melanoma. Fianlimab and cemiplimab are high-affinity, human, hinge-stabilized IgG4 monoclonal antibodies, targeting LAG-3 and PD-1, respectively. We report results from a first-in-human phase-I study of fianlimab and cemiplimab safety and efficacy in various malignancies including advanced melanoma. METHODS Patients with advanced melanoma were eligible for enrollment into four cohorts: three for patients without and one for patients with previous anti–PD-1 therapy in the advanced disease setting. Patients were treated with fianlimab 1,600 mg and cemiplimab 350 mg intravenously once every 3 weeks for up to 51 weeks, with an optional additional 51 weeks if clinically indicated. The primary end point was objective response rate (ORR) per RECIST 1.1 criteria. RESULTS ORRs were 63% for patients with anti–PD-1–naïve melanoma (cohort-6; n = 40; median follow-up 20.8 months), 63% for patients with systemic treatment–naïve melanoma (cohort-15; n = 40; 11.5 months), and 56% for patients with previous neo/adjuvant treatment melanoma (cohort-16; n = 18, 9.7 months). At a median follow-up of 12.6 months for the combined cohorts (6 + 15 + 16), the ORR was 61.2% and the median progression-free survival (mPFS) 13.3 months (95% CI, 7.5 to not estimated [NE]). In patients (n = 13) with previous anti–PD-1 adjuvant therapy, ORR was 61.5% and mPFS 12 months (95% CI, 1.4 to NE). ORR in patients with previous anti–PD-1 therapy for advanced disease (n = 15) was 13.3% and mPFS 1.5 months (95% CI, 1.3 to 7.7). Treatment-emergent and treatment-related adverse events ≥grade 3 (G3) were observed in 44% and 22% of patients, respectively. Except for increased incidence of adrenal insufficiency (12%-G1-4, 4%-G3-4), no new safety signals were recorded. CONCLUSION The current results show a promising benefit-risk profile of fianlimab/cemiplimab combination for patients with advanced melanoma, including those with previous anti–PD-1 therapy in the adjuvant, but not advanced, setting.
Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus
Authors: Shashikadze Bachuki , Flenkenthaler Florian , Kemter Elisabeth , Franzmeier Sophie , Stöckl Jan B. , Haid Mark , Riols Fabien , Rothe Michael , Pichl Lisa , Renner Simone , Blutke Andreas , Wolf Eckhard , Fröhlich Thomas 
Published: June 2024

ABSTRACT
Growing evidence shows that the lung is an organ prone to injury by diabetes mellitus. However, the molecular mechanisms of these pulmonary complications have not yet been characterized comprehensively. To systematically study the effects of insulin deficiency and hyperglycaemia on the lung, we combined proteomics and lipidomics with quantitative histomorphological analyses to compare lung tissue samples from a clinically relevant pig model for mutant INS gene-induced diabetes of youth (MIDY) with samples from wild-type littermate controls. Among others, the level of pulmonary surfactant-associated protein A (SFTPA1), a biomarker of lung injury, was moderately elevated. Furthermore, key proteins related to humoral immune response and extracellular matrix organization were significantly altered in abundance. Importantly, a lipoxygenase pathway was dysregulated as indicated by 2.5-fold reduction of polyunsaturated fatty acid lipoxygenase ALOX15 levels, associated with corresponding changes in the levels of lipids influenced by this enzyme. Our multi-omics study points to an involvement of reduced ALOX15 levels and an associated lack of eicosanoid switching as mechanisms contributing to a proinflammatory milieu in the lungs of subjects with diabetes mellitus.
How to Design the Ask? Funding Units vs. Giving Money
Authors: Epperson Raphael , Diederich Johannes , Goeschl Timo 
Published: June 2024

Unit donations are an alternative fundraising scheme in which potential donors choose how many units of a charitable good to fund rather than just giving money. Based on evidence from an online experiment with 8,673 participants, we demonstrate that well-designed unit donation schemes can significantly boost giving above and beyond the standard money donation scheme. A decomposition of the underlying mechanisms shows patterns consistent with the conjecture that unit donations increase impact salience and leverage donors’ cognitive biases by changing the metric of the donation space. Managers need to weigh the potential fundraising benefits of a unit scheme against some important challenges, such as expert handling of the choice of unit sizes. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: Funding by Heidelberg University [Field of Focus IV under the Excellence Strategy] and the Austrian Science Fund [Grant SFB F63] is gratefully acknowledged. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.00157 .
Preparation and properties of tellurite glass-based CsPb(BrCl)3@glass fluorescent film for a white light emitting diode color converter
Authors: Li Bo , He Ziyu , Zhao Guoying , Qiao Xin , Wang Zhongzhi , Fang Yongzheng , Shi Liqun 
Published: June 2024

Perovskite nanocrystal glass has the advantages of narrow-band emission, easy tuning, and stable structural, physical, and chemical properties, and can be used to mix with other colored materials for white light modulation. The current white light mode widely adopts the packaging method of blue light chip and yellow phosphor, which has the problem of a blue-yellow cavity and low light quality. In this work, the central wavelength of CsPb(BrCl)3 can be adjusted continuously ranging from 463 nm to 486 nm by adjusting the relative ratio of bromine to chlorine in nanocrystals. On the basis of the previous design of YAG:Ce phosphor-in-glass, perovskite nanocrystal glass powder as a color compensator was introduced into the tellurite glass matrix to form a doubly encapsulated system by low-temperature co-sintering. The yellow phosphor and perovskite nanocrystal glass maintain good structural integrity in the glass matrix. By combining the double-package fluorescent material with the blue chip, the continuous adjustment of chromaticity coordinates along the saddle line is realized, and the color-rendering index is also improved to 81.3.
Multi-lens component used for a LWIR field-integral gas spectral imager
Authors: Xu Huanyao , Xu Liang , Zhu Wanjiang , Zhang Lei 
Published: June 2024

This paper reports a miniature multi-lens component used for a LWIR field-integral gas spectral imager. The component is designed for crosstalk minimization and consists of a 4∗3 array of micro-lenses and a detector. To reduce the cost, the detector is uncooled and the optical parameters of the 12 micro-imaging lenses are identical. These include 3.38 mm focal length and 35° field-of-view. The F/# is designed to be 1.2 to increase the luminous flux of the imager. After image quality evaluation and tolerance analysis, the micro-imaging lens has good imaging quality, is insensitive to tolerances, and is easy to fabricate. To enhance the environmental stability of the component, a temperature control system was designed to depress the temperature drift. In addition, the athermalization of the micro-imaging lens was beneficial. The performance test of the component shows that the NETD of the 12 micro-imaging lenses is less than 90 mK and most of them are less than 65 mK, and an image of an ethylene gas cloud observed by the component is also shown. The component has been integrated to the spectral imagers, and crosstalk is analyzed.