bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Advisory Opinions to Binding Decisions: The new Appeal Mechanism of the Un system of Administration of Justice
Authors: Vargiu Paolo 
Published: March 2011

AbstractIn 2009 the United Nations launched a new two-tier system of administration of justice. The system is composed of two standing bodies, the United Nations Dispute Tribunal (UNDT) and the United Nations Appeals Tribunal (UNApT), the latter acting as an appeals mechanism against decisions of the UNDT. The former system foresaw the United Nations Administrative Tribunal (UNAT) as the sole body of administration of justice within the UN, while the International Court of Justice (ICJ) acted as review mechanism on the decisions of the UNAT. However, this review system was abolished in 1995 and, since then, no option was available to unsuccessful (or partially successful) staff members for having a UNAT judgment reviewed. The lack of any option for review led to criticisms and instances for reform of the whole system, which eventually led to the establishment of a Redesign Panel, which suggested the establishment of a two-tier system of administration of justice, with the aim of meeting the 'basic standards of due process established in international human rights instruments'. The recently established Appeals Tribunal should fill the gap created by the abolition of the ICJ competence to review the judgments rendered by the UNAT. This article evaluates the improvement to the system represented by the establishment of the United Nations Appeals Tribunal in three main steps. The first is the identification of the shortcomings of the previous review mechanism before the ICJ. The second is the overview of the problems of the former system of administration of justice within the UN. The third and final step is the analysis of the scope of jurisdiction of the new UNApT.
Galen and Astrology: A Mésalliance?
Authors: Cooper Glen 
Published: March 2011

AbstractThe author examines the question of Galen's affinity with astrology, in view of Galen's extended astrological discussion in the De diebus decretoriis (Critical Days). The critical passages from Galen are examined, and shown to be superficial in understanding. The author performs a lexical sounding of Galen's corpus, using key terms with astrological valences drawn from the Critical Days, and assesses their absence in Galen's other works. He compares Galen's astrology with the astrology of Ptolemy's Tetrabiblos, and evaluates their respective strategies of scientific reasoning. Three types of inference are introduced and applied to Galen's astrology. Finally, he concludes that the empirical side of Galen's science does not depend upon astrological methods or concepts, but that these were introduced for their rhetorical effect in presenting his new medical methodology. It is suggested that continued attention to Galen's astrology has obscured the truly important empirical scientific method that Galen developed.
"Not worth one Groat": The Status, Gentility and Credit of Lawrence and Sarah Crabb of Antigua
Authors: Barber Sarah 
Published: March 2011

AbstractThis article recreates the lives of two settlers in Antigua between the years 1690 and 1740. As such, it is a key addition to the paltry number of studies of the island of Antigua and the other Leeward Islands of the West Indies. It takes as its base point the study of the Antigua settler elite identified by Richard Sheridan in his article, now forty years old, which constructed the institutional systems of landholding, taxation, customs and the Slave Trade which produced so-called Plantation Society. In the years preceding this, however, life for everyone concerned in the West Indies was uncertain and insecure. is was as much the case for those at the top of the socio-political ladder, such as island governors and Crown viceroys, as for relatively modest settlers, such as the subjects of this essay, Lawrence and Sarah Crabb. For all of those who were incorporated into the 18thcentury Plantocracy, many more were sacrificed in the struggles of early capitalism, buoyed up not by the level of 'credit' that they were accorded, but by the levels of debt they carried. The construction of a social history of modest settlers is made possible through the survival of documents which were kept by the Crabb's agent, George Moore, and which he would subsequently use in a Chancery case against his late friend's widow. These manuscripts have not been used before, except for occasional references to the legal precedents established by the case, Moore v. Meynell, and, given the paucity and patchiness of manuscript survivals for the Caribbean in the seventeenth century, show what can be reconstructed from otherwise overlooked sources. The result is a study of the measurement of a person's worth, and the increasing elision of God and Mammon in gauging credit, value and trust. In the case of the Crabbs, particularly because Lawrence was himself a man of little initial wealth who clawed his way up through his own ingenuity and his wife's family's West Indian estates, we are able to demonstrate how the language of credit and worthiness applied not only to men of business and politics but also to women.
Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen
Authors: McGaha Tracy L. , Chen Yunying , Ravishankar Buvana , van Rooijen Nico , Karlsson Mikael C. I. 
Published: March 2011

Abstract
Marginal zone macrophages (MZMs) are a small subset of specialized splenic macrophages known to interact with apoptotic material entering the spleen from circulation. To evaluate whether MZMs regulate immunity to apoptotic material we depleted MZMs and assessed innate and adaptive immune responses to apoptotic cells administered systemically. MZM depletion altered the spatial localization of apoptotic cells, which accumulated in T-cell areas of the lymphoid follicles. MZM depletion also enhanced phagocytosis of apoptotic cells by red pulp (CD68+F4/80+) macrophages, which expressed increased CD86, MHCII, and CCR7. MZM depletion led to increased production of proinflammatory cytokines and enhanced lymphocyte responsiveness to apoptotic cell antigens. Furthermore, we found that MZM depletion accelerated autoimmune disease progression in mice genetically prone to systemic lupus erythematosus and caused significant mortality in wild-type mice repeatedly exposed to exogenous apoptotic thymocytes. These findings support the hypothesis that MZMs are central in the clearance of apoptotic cells to minimize the immunogenicity of autoantigens.
Popular Royalists, Empire, and Politics in Southwestern New Granada, 1809 – 1819
Authors: Echeverri Marcela 
Published: March 2011

Abstract
This article examines the royalist forces that rose in defense of the colonial order in the southwestern region of New Granada, Colombia, a royalist stronghold where slaves and local Indians united with Spanish forces to fight against independence armies. Enslaved blacks and Indians were perceived by royalist elites as valuable allies, and for that reason elites were willing to negotiate and offer concessions to secure their loyalty. I describe the complex negotiations with Indians in terms of tribute payment, and with slaves over freedom, that have been left completely out of an independence narrative that has assumed that Indians and blacks participated as royalists exclusively as cannon fodder or always in disadvantageous terms. My contribution is specifically to provide insight into the ways in which Indians and slaves positioned themselves as political actors in the context of empire, and how their particular political histories determined their negotiation with royalist factions during the independence process, when, for both groups, militia service became an avenue for social mobility and provided new means of protecting and expanding their rights.
Biological and genetic factors associated with ABCB1 and pregnane-X-receptor expressions in peripheral blood mononuclear cells in the STANISLAS cohort
Authors: Jeannesson Elise , Siest Gerard , Herbeth Bernard , Albertini Laetitia , Shahabi Payman , Pfister Michele , Visvikis-Siest Sophie 
Published: March 2011

Abstract

Background: ABCB1 is a membrane transporter ubiquitously expressed particularly in peripheral blood mononuclear cells (PBMCs). Resistance to drugs is associated with genetic variations of its gene and with modulation of its expression through the pregnane-X-receptor (PXR) transcription factor. We have previously shown that ABCB1polymorphisms were associated with blood lipid concentrations.

Methods: We wanted to investigate the variation factors and the genetic determinants of ABCB1 and PXR expressions in PBMCs, and their interrelationships with plasma lipid levels. ABCB1 and PXR mRNA were quantified by real-time quantitative RT-PCR in PBMCs of 42 men and 39 women.

Results: ABCB1 and PXR were both expressed in PBMCs of all individuals, but their expressions were not significantly correlated. ABCB1 mRNA was correlated with body mass index (BMI; p=0.01) and age (p=0.03). In women, lymphocyte count also correlated with ABCB1 transcripts (p<0.01). After adjustment for BMI, correlation with age disappears. PXR mRNA expression depends on gender with men expressing higher PXR levels (p=0.01). PXR expression also correlates with γ-glutamyltransferase (GGT; p=0.02), but this disappeared after adjustment.

Conclusions: Neither ABCB1 nor PXR expressions correlate with ABCB1gene variants. Finally, association between ABCB1 or PXR expression in PBMCs and lipid or apolipoprotein plasma concentrations were not significant in this subset of healthy subjects. These results should be confirmed in a larger population sample and extended to patients with various cardiovascular risk profiles.
CYP2D6 genotyping in breast cancer patients by liquid chromatography-electrospray ionization mass spectrometry
Authors: Beer Beate , Plattner Sabine , Hubalek Michael , Oberguggenberger Anne , Sztankay Monika , Meraner Verena , Achleitner Regina , Oberacher Herbert 
Published: March 2011

Abstract
The application of cytochrome P450 2D6 (CYP2D6) genotyping to allow a personalized treatment approach for breast cancer patients undergoing endocrine therapy has been repeatedly discussed. However, the actual clinical relevance of the CYP2D6 genotype in the endocrine treatment of breast cancer still remains to be elucidated. A major prerequisite for the successful and valid evaluation of the CYP2D6 genotype with regard to its pharmacokinetic and clinical relevance is the availability of a comprehensive, accurate and cost-effective CYP2D6 genotyping strategy. Herein we present a CYP2D6 genotyping assay employing polymerase chain reaction (PCR)-ion pair reversed-phase high-performance liquid chromatography-electrospray ionization time-of-flight mass spectrometry (ICEMS). The genotyping strategy involves the simultaneous amplification of nine variable regions within the CYP2D6 gene by a two-step PCR protocol and the direct analysis of the generated PCR amplicons by ICEMS. The nucleotide composition profiles generated by ICEMS enable the differentiation of 37 of the 80 reported CYP2D6 alleles. The assay was applied to type the CYP2D6 gene in 199 Austrian individuals including 106 breast cancer patients undergoing tamoxifen treatment. The developed method turned out to be a highly applicable, robust and cost-effective approach, enabling an economical CYP2D6 testing for large patient cohorts.
Pattern of Expression of Cell Cycle–related Proteins in Malignant Transformation of Sinonasal Inverted Papilloma
Authors: Kim Sun-Gui , Lee O-Young , Choi Jin-Woong , Park Yong-Ho , Kim Yong-Min , Yeo Min-Kyung , Kim Jin-Man , Rha Ki-Sang 
Published: March 2011

Background It has been suggested that sinonasal inverted papilloma (IP) can progress to squamous cell carcinoma (SCC); however, mechanisms of malignant transformation are not fully understood. This study investigated alterations in the expression of cell cycle–related proteins in a multistep process of malignant transformation of IPs. Methods The expression of cell cycle–related proteins, including p53, p21, p16, and p63, was evaluated by immunohistochemistry in 21, 56, 7, and 18 cases of nasal polyps, IPs, IPs with dysplasia, and IPs with SCC, respectively. Furthermore, we determined the possible correlation between the expression of these proteins and clinicopathological variables in patients with IPs with SCC. Results Expression of p53 was found only in 8 of 18 IPs with SCC (44.4%). The frequency of p21 positivity was significantly higher in IPs with dysplasia (71.4%) and IPs with SCC (77.8%) compared with nasal polyps (0%) and IPs (12.5%). A p16 positivity was observed in 82.1% of IPs and 57.1% of IPs with dysplasia, whereas 83.3% of IPs with SCC showed an apparent loss of p16 protein expression. A p63 positivity was found in all specimens, but the percentage of positive cells was significantly increased in IPs with dysplasia and IPs with SCC compared with nasal polyps and IPs. There was no significant correlation between the expression of these proteins and clinicopathological variables, such as tumor stage, histological differentiation, and the proportion of malignant areas in patients with IPs with SCC. Conclusion Alteration of cell cycle–related proteins may contribute importantly to the malignant transformation from IP to SCC.
Mucosal Cysts in the Paranasal Sinuses: Long-term Follow-up and Clinical Implications
Authors: Moon Il Joon , Kim Sang-Wook , Han Doo Hee , Shin Jae Min , Rhee Chae-Seo , Lee Chul Hee , Min Yang-Gi 
Published: March 2011

Background Although mucosal cysts in the paranasal sinuses (PSMCs) are commonly detected, the long-term follow-up studies of PSMCs are sparse. This study evaluated the natural course of PSMCs and identified risk factors for the disease progression. Methods A total of 133 subjects with PSMCs who underwent health checkup including brain magnetic resonance imaging more than two times with an interval of ≥ 24 months between January 2000 and December 2009 were included. The characteristics of PSMCs were analyzed on the initial and follow-up images. Nasal symptoms, smoking status, and comorbid medical conditions were evaluated using structured questionnaires and medical records. Results The mean follow-up duration was 40.38 months (range, 24.0–109.8 months). The mean size of PSMCs decreased from 15.07 to 12.73 mm. Only 8.3% of subjects showed an increase in size, whereas the size of cysts was decreased or unchanged in the remaining 91.7% of subjects. Six (4.5%) subjects complained of nasal symptoms during follow-up and subsequent sinusitis was developed in 3% of subjects. An increase in cyst size was associated with development of sinusitis (odds ratio = 45.375). Initial size of cysts >20 mm and bilateral location were significant risk factors for progression (p = 0.019 and p = 0.039, respectively). Conclusion The majority of PSMCs in this follow-up study were decreased or unchanged and most subjects were asymptomatic. Just observation is enough for most PSMCs. However, those who have a large cyst (>20 mm) or bilateral cysts at initial diagnosis were at risk for disease progression and should be regularly followed.
Nasal Eosinophilia can Predict Bronchial Hyperresponsiveness in Persistent Rhinitis: Evidence for United Airways Disease Concept
Authors: Canbaz Pelin , üskudar-Teke Havva , Aksu Kurtulus , Keren Metin , Gulbas Zafer , Kurt Emel 
Published: March 2011

Background Nasal eosinophils may be indicative of bronchial hyperresponsiveness (BHR) in rhinitis concerning the “united airways disease” theory. This study was designed to evaluate the relationship between nasal eosinophilia and BHR in persistent perennial rhinitis patients. Methods Thirty-seven patients (12 males and 25 females, mean age: 33.3 ± 10.4 years) were included in the study. Skin-prick test, nasal symptom score, nasal smears, methacholine bronchial challenge test, and nasal rhinometry were obtained in all patients. Eosinophil count in nasal smears was expressed as a percentage of the total cells. None of the patients had asthma. Results There was no difference between the number of atopic and nonatopic patients having BHR (4/20 versus 4/17; chi-squared = 0.07; p > 0.05). Total nasal flow was lower and percentage of nasal eosinophils was higher in the patients with BHR than in patients without BHR (p = 0.012 and p = 0.009, respectively). A cutoff point of 68% nasal eosinophils yielded a sensitivity of 100% (63.1–100) and a specificity of 58.6% (38.9–76.5) to determine the presence of BHR. Positive likelihood ratio for the value of eosinophils above cutoff value was 2.42 (1.8–3.3). Conclusion This study shows the relationship between nasal eosinophils and BHR in persistent perennial rhinitis patients. Nasal eosinophil percentage below cutoff value indicates that a patient does not have BHR.
Allergic Rhinitis and Secondhand Tobacco Smoke: A Population-based Study
Authors: Lin Sandra Y. , Reh Douglas D. , Clipp Sandra , Irani Laili , Navas-Acien Ana 
Published: March 2011

Background Allergic rhinitis (AR) is a common disease that affects approximately one-fifth of the U.S. population. Few studies have evaluated the association between secondhand tobacco smoke (SHS) exposure and the impacts on symptom severity in AR. In this study, we evaluated the association of SHS and AR in a community-based study of adult nonsmokers. Methods In Washington County, Maryland, 83 subjects with AR (physician diagnosed or reported skin test positive), and 117 nonallergic subjects from the same community were recruited and interviewed. A validated questionnaire was used to assess past and present SHS exposure as well as disease-specific quality of life. Results SHS was reported in 34/83 allergic subjects. Compared with AR subjects with no SHS exposure, subjects with AR and SHS were more likely to report a family history of chronic sinusitis (p = 0.04) and use nasal decongestants (p = 0.012). There was also a borderline association with reporting more severe nasal obstruction (p = 0.14) and nasal drainage (p = 0.08). Compared with nonallergic subjects, allergic subjects were more likely to report longer SHS exposure currently (adjusted mean difference = 1.6 hours/week; p = 0.01) and 20 years ago (adjusted mean difference = 2.9 hours/week; p = 0.03). Conclusion Past and current SHS may be a risk factor for AR. Allergic subjects with SHS exposure were more likely to use nasal decongestants and to report more severe nasal symptoms such as nasal obstruction and nasal drainage than nonexposed allergic subjects.
Use of narrow band imaging in evaluation of possible nasopharyngeal carcinoma
Authors: Ho Ching-Yin , Lee Yi-Lun , Chu Pen-Yuan 
Published: March 2011

Background This study was designed to evaluate the narrow band imaging (NBI) system for its ability to differentiate between malignant neoplasm and benign neoplasm by real-time image during nasopharyngoscopy, the quality of the visualization, and the limitation of the NBI in nasopharyngeal lesions. Methods Between June 2009 and May 2010, 63 patients who had a suspected nasopharyngeal tumor via nasopharyngoscopy at Taipei Veterans General Hospital, Taiwan, were included in this study. All of the patients received nasopharyngoscopy with conventional view and NBI view and nasopharyngeal biopsy. The patients were divided into two groups depending on the pathological results: nasopharyngeal carcinoma (NPC) and lymphoid hyperplasia/chronic inflammation (LH). Results Forty-one patients were in the NPC group and 22 patients were in the LH group. The pattern of the NBI view showed regular cobblestone in the LH group, except for one patient. The pattern of the NBI view showed an irregular engorged vascular pattern and/or microvascular proliferative pattern in 32 of 41 NPC patients (78.0%). The sensitivity, specificity, positive predictive value, and negative predictive value of NBI in nasopharynx (NP) were 78.0, 95.5, 97.0, and 70.0%, respectively, in NP neoplasm. Conclusion NBI could be helpful in differentiating benign and malignant neoplasm in the NP region. Using NBI in NP regions had some limitations, including bleeding and mucus coating.
Polymorphisms in the nitric oxide synthase 1 gene are associated with severe chronic rhinosinusitis
Authors: Zhang Yuan , Endam Leandra Mfuna , Filali-Mouhim Abdelali , Bossé Yohan , Castano Roberto , Desrosiers Martin 
Published: March 2011

Background Nitric oxide (NO), is a biological messenger molecule and a component of innate immunity, with important roles in the regulation of inflammation and in defense against bacterial biofilms. Polymorphisms in genes regulating NO production have the potential for a role in the development of chronic rhinosinusitis (CRS). The purpose of this study was to determine whether polymorphisms in genes regulating NO synthesis are associated with CRS. Methods An established population of 206 individuals with severe CRS and 196 postal code–matched controls was previously screened using a pooling genome-wide associations study to estimate allelic frequency. Genes regulating NO synthesis with a maximal probability of association were identified. High-probability single nucleotide polymorphisms SNPs from the NO synthase (NOS1) and its ligand NOS1 adaptor protein (NOS1AP) genes were retained for individual genotyping. PLINK software was used to determine association. Results Sixteen SNPs were genotyped successfully with a genotype distribution in agreement with Hardy-Weinberg equilibrium. Two SNPs for NOS1 (rs1483757 and rs9658281) were significantly associated with CRS, with a protective effect. The severe subphenotype showed stronger associations. Subgroup analysis for the presence of nasal polyps, origin, and gender did not influence strength of associations. Conclusion These data suggest that polymorphisms in the NOS1 gene may play a role in the susceptibility to develop CRS. Study findings apply to patients with severe CRS, unresponsive to surgery.
Bacterial interference in upper respiratory tract infections: A systematic review
Authors: Benninger Michael , Brook Itzhak , Bernstein Joel M. , Casey Janet R. , Roos Kristian , Marple Bradley , Farrar Judith R. 
Published: March 2011

Background Published definitions of bacterial interference (BI) differ, some focusing on changes in the normal flora and others on changes in subsequent infection. A need for consensus was identified at a roundtable discussion of BI in upper respiratory tract infections (URTI). We conducted a systematic review of the available data to justify a consensus definition of BI specific to URTI as “a dynamic, antagonistic interaction between at least 2 organisms that affects the life cycle of each, changes the microenvironment, and alters the organisms’ colonization, invasiveness, and ability to affect the health of the host.” Methods Continued communication among the faculty postroundtable was used to identify and refine the search criteria to (1) in vitro and in vivo studies assessing bacterial URTI, (2) BI evaluated by response to treatment of URTI with antimicrobial agents, and (3) bacterial function in relation to interactions between normal (nonpathogenic) and pathological flora. The criteria were applied to systematic searches of MEDLINE (1950 onward), EMBASE (1974 onward), and the Cochrane Library (2007). Results Twenty-nine studies met the inclusion criteria, most focused on children with recurrent infections. Qualitative analysis supports the consensus definition. Interfering organisms affected the life cycle of test pathogens and inhibited their colonization, invasiveness, and health outcomes. Data were insufficient for statistical analysis. Conclusion Interactions between interfering organisms and potential pathogens isolated from the same host can alter response to infection and treatment. More studies are needed, particularly in adults, to understand the role of interfering organisms, the influence of antibiotics, and the potential for recolonization posttreatment.