bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory Activity of Quercetin, Rutin, and Hyperoside against Xanthine Oxidase: Kinetics, Fluorescence, and Molecular Docking
Authors: Yu Yali , Xiong Yingzhu , Tong Siman , Li Yanli , Cai Rongcan , Zhang Xv , Gao Feng 
Published: May 2024

Introduction:
Quercetin (Qc), rutin (Ru), and hyperoside (Hyp) are three common
polyphenols widely distributed in the plant kingdom.

Methods:
This study explored the inhibition and mechanisms of Qc, Ru, and Hyp against xanthine
oxidase (XOD) by enzyme kinetic analysis, fluorescence analysis, and molecular docking.
The inhibitory activities of the three polyphenols on XOD showed the following trend: quercetin
> hyperoside > rutin, with IC50 values of 8.327 ± 0.36 μmol/L, 35.215 ± 0.4 μmol/L and
60.811 ± 0.19 μmol/L, respectively. All three polyphenols inhibited xanthine oxidase activity in
a mixed-competitive manner. Synchronous fluorescence results demonstrated that three polyphenols
binding to XOD were spontaneous and showed static quenching.

Results:
The binding of the three polyphenols to XOD is mainly driven by hydrogen bonding
and van der Waals forces, resulting in the formation of an XOD-XA complex with only one affinity
binding site. The binding sites of the three RSFQ phenolic compounds are close to those of
tryptophan. Molecular docking showed that all three polyphenols enter the active pocket of XOD
and maintain the stability of the complex through hydrogen bonding, hydrophobic interaction,
and van der Waals forces.

Conclusion:
The results provide a theoretical basis for quercetin, rutin, and hyperoside to be
used as function factors to prevent hyperuricemia.
Expression of LASS2 Can be Regulated by Dihydroartemisinin to Regulate Cisplatin Chemosensitivity in Bladder Cancer Cells
Authors: Qiao Xuhua , Xue Rongbo , Li Shijie , Li Jun , Ji Chundong 
Published: May 2024

Introduction:
The aim of this study was to investigate the potential of dihydroartemisinin
to augment the efficacy of cisplatin chemotherapy through the modulation of LASS2
expression.

Methods:
TCMSP, CTR-DB, TCGA-BLC, and other databases were used to analyze the possibility
of LASS2 as the target gene of dihydroartemisinin. Cell experiments revealed the synergistic
effect of DDP and DHA. Animal experiments showed that DHA inhibited the growth of
DDP-treated mice. In addition, WB, real-time PCR, and immunohistochemical analysis showed
that DHA enhanced LASS2 (CERS2) expression in bladder cancer cells and DDP-treated mice.

Results:
LASS2 is associated with cisplatin chemosensitivity.LASS2 expression levels are different
between BLC tissues and normal tissues. COX analysis showed that patients with high
LASS2 expression had a higher cumulative overall survival rate than those with low LASS2
expression. The Sankey plot showed that LASS2 expression is lower in BLC tissues with more
advanced stage and distant metastasis. The docking score of DHA and LASS2 reached the maximum
value of -5.5259, indicating that DHA had a strong binding affinity with LASS2 targets.
CCK8 assay showed that the most effective concentration ratio of DHA to DDP was 2.5 μg/ml +
10μg/ml. In vivo experiments showed that DHA inhibited tumor growth in cisplatin-treated mice.
In addition, WB, RT-qPCR, and immunohistochemical analysis showed that DHA was able to
enhance LASS2 expression in BLC cells and DDP-treated mice.

Conclusion:
The upregulation of LASS2 (CERS2) expression in bladder cancer cells by DHA
has been found to enhance cisplatin chemosensitivity.
Rare Columnar Cell Variant of Papillary Thyroid Carcinoma with Cervical
Spine Metastasis: A Case Report
Authors: Yu Jihye , Yang Goeun , Oh Ha Yeun , Ryu Yoon Jong 
Published: May 2024

Background::
Columnar cell carcinoma is a rare subtype of papillary thyroid carcinoma (CCV-PTC) that accounts for only 0.15% to 0.2% of all Papillary
Thyroid Carcinomas (PTCs). It has aggressive behavior but a better prognosis than anaplastic thyroid carcinoma.

Case Presentation::
A 64-year-old female presented with a huge thyroid mass resulting in compressive myelopathy and was diagnosed as CCV-PTC, not anaplastic
carcinoma. After multidisciplinary discussions, we decided to proceed with otolaryngological, thoracic, and orthopaedic surgery. All tumours were
unresectable, and we planned to proceed with R2 resection to resolve the gait disturbance and anterior fusion to resolve spinal instability.

Conclusion::
Advanced-stage thyroid cancer is relatively uncommon, but desirable treatment effects can be expected through accurate pathological diagnosis.
Immunohistochemical staining and tissue-specific markers can be helpful.
Fibrosarcomatous Transformation in Dermatofibrosarcoma Protuberans of the
Male Breast and its Association with Magnetic Resonance Imaging and
Immunohistopathologic Features
Authors: Kang Sang Yull , Choi Eun Jung , Jang Kyu Yun 
Published: May 2024

Background:
Dermatofibrosarcoma Protuberans (DFSP) is a rare soft tissue sarcoma, accounting for approximately 1% of all tumors; however, DFSP of the
breast is extremely rare. Moreover, DFSP generally has a low malignant potential and is characterized by a high rate of local recurrence along with
a small but definite risk of metastasis. The risk of metastasis is higher in fibrosarcomatous transformation in DFSP than in ordinary DFSP.

Case Report:
We have, herein, reported a case of a 61-year-old male patient with fibrosarcomatous transformation in DFSP. Preoperative Dynamic Contrastenhanced
Magnetic Resonance Imaging (DCE-MRI) of the breast revealed an oval-shaped mass with heterogeneous internal enhancement, a large
vessel embedded within, and a washout curve pattern on kinetic curve analysis. The mass exhibited a hyperintense signal on Diffusion-weighted
Imaging (DWI), with a low apparent diffusion coefficient value. Histologically, the bland spindle tumor cells were arranged in a storiform pattern.
Areas with the highest histological grade demonstrated increased cellularity, cytological atypia, and mitotic activity. Immunohistochemically,
Ki-67 and p53 were highly expressed.

Conclusion:
Recognizing the risk and accurately diagnosing fibrosarcomatous transformation in male breast DFSP are critical for improving prognosis and
establishing appropriate treatment and follow-up plans. This emphasizes the significance of combining immunohistopathological features with
DCE-MRI and DWI to assist clinicians in the early and accurate diagnosis of sarcomas arising from male breast DFSP.
Insights From a Clinically Orientated Workshop on Health Care Cybersecurity and Medical Technology: Observational Study and Thematic Analysis
Authors: Straw Isabel , Brass Irina , Mkwashi Andrew , Charles Inika , Soares Amelie , Steer Caroline 
Published: May 2024

Background
Health care professionals receive little training on the digital technologies that their patients rely on. Consequently, practitioners may face significant barriers when providing care to patients experiencing digitally mediated harms (eg, medical device failures and cybersecurity exploits). Here, we explore the impact of technological failures in clinical terms.

Objective
Our study explored the key challenges faced by frontline health care workers during digital events, identified gaps in clinical training and guidance, and proposes a set of recommendations for improving digital clinical practice.

Methods
A qualitative study involving a 1-day workshop of 52 participants, internationally attended, with multistakeholder participation. Participants engaged in table-top exercises and group discussions focused on medical scenarios complicated by technology (eg, malfunctioning ventilators and malicious hacks on health care apps). Extensive notes from 5 scribes were retrospectively analyzed and a thematic analysis was performed to extract and synthesize data.

Results
Clinicians reported novel forms of harm related to technology (eg, geofencing in domestic violence and errors related to interconnected fetal monitoring systems) and barriers impeding adverse event reporting (eg, time constraints and postmortem device disposal). Challenges to providing effective patient care included a lack of clinical suspicion of device failures, unfamiliarity with equipment, and an absence of digitally tailored clinical protocols. Participants agreed that cyberattacks should be classified as major incidents, with the repurposing of existing crisis resources. Treatment of patients was determined by the role technology played in clinical management, such that those reliant on potentially compromised laboratory or radiological facilities were prioritized.

Conclusions
Here, we have framed digital events through a clinical lens, described in terms of their end-point impact on the patient. In doing so, we have developed a series of recommendations for ensuring responses to digital events are tailored to clinical needs and center patient care.
Political Communication and Personal Imaging (Study of Giring Ganesha’s Political Speech at Indonesian Solidarity Party Anniversary)
Authors: Sukendar Markus Utomo 
Published: May 2024

Speech delivery is a form of communication skill that aims to convey certain messages to the public. In giving speeches or giving speeches, especially in political speeches, a political party figure carries out the duties and carries out the functions of his party. The purpose of the research is to dissect the communication message conveyed by Giring Ganesha as the general chairman of PSI in the Political Speech at PSI's 7th Anniversary, as well as to find out the purpose of Giring Ganesha as a representation of PSI and the impression that is built as part of political imagery. This research is a qualitative exploratory research, which is used to explore data so that it can provide in-depth understanding and understanding of the object of research. This study is directed to clearly describe the image formed by Giring Ganesha who is also the General Chair of the Indonesian Solidarity Party in his political speech for the 7th Anniversary of the Indonesian Solidarity Party on December 22, 2021. The research method used in this study is discourse analysis by Roger Fowler et al. According to Focault, discourse is a field of all statements, sometimes as an individualization of a group of statements, and sometimes as a regulatory practice seen from a number of statements. (1) Giring Ganesha's speech as a party representative further strengthens PSI's support for President Joko Widodo's Government and it is recognized that President Jokowi's magnetism is still very strong in gaining constituent support, especially young people. (2) As a form of modern, adaptive, intoxicated Party image.
Kontekstualitas Elaboration LIKELIHOOD Model pada Model Komunikasi Gerakan Santri Menulis
Authors: Syamsiyah Sri , Suhariyanto  , Fitriyanti Ayang 
Published: May 2024

Arus informasi yang membeludak akibat perkembangan teknologi, terkadang membuat sebagian masyarakat menjadi bingung akan sebuah informasi. Dalam kondisi ini, maka peran pesantren termasuk di dalamnya santri juga menjadi penting. Santri diharapkan turut memberi kontribusi antara lain melalui tulisan untuk merespon berbagai perkembangan zaman tersebut. Tulisan-tulisan mereka diharapkan bisa memberikan informasi yang positif yang memenuhi ruang-ruang media. Untuk dapat memiliki motivasi dan dapat menulis dengan baik, maka santri perlu berlatih menulis berbagai jenis tulisan termasuk tulisan jurnalistik. Hal inilah yang menjadi permasalahan pada penelitian ini bagaimana membangun model komunikasi yang dapat memberi motivasi para santri untuk menulis. Penelitian ini menggunakan studi kasus pada pelatihan jurnalistik yang santri dilakukan oleh Surat Kabar Suara Merdeka dalam acara ‘’Gerakan Santri Menulis (GSM)’’ 2023. Penelitan ini mengunakan teori Elaboration Likelihood Model (ELM) dengan melihat elemen central route dan pheriferal route. Penelitian menghasilkan adanya model komunikasi yang memberikan ruang pada konteks baik pada central route maupun peripheral route pada ELM. Ruang konteks tersebut antara lain dengan melihat tingkat pemahaman dan kondisi para santri serta perkembangan teknologi.

The overwhelming flow of information as a consequence of technological development occasionally makes some people confused about whether the information circulating is true or not. Responding to such conditions, the role of pesantren (Islamic traditional boarding school), including its santris (pesantren students), is crucial. Hopefully, santri can contribute to responding to the current development, among others through writing activities. Their articles are expected to provide positive information to fulfill media space. In order to have motivation and capability in writing, a santri should practice various kinds of writings, including journalistic writing. The issue examined in this paper is how to develop a communication model that can motivate santri to write. This research uses a case study on a journalistic training program for santris organized by Suara Merdeka daily newspaper. The program was called Gerakan Santri Menulis (Santri Writing Movement). The study uses the theory of Elaboration Likelihood Model (ELM) by examining the elements of central route and peripheral route. The research results in a communication model that gives context a space both the central route and peripheral route. This context includes, among other things, looking at the level of understanding and condition of the santris as well as technological developments.
Manajemen Impresi Prabowo Subianto dalam Menghadapi Pemilihan Presiden 2024
Authors: Abdurrohman Yusuf 
Published: May 2024

Salah satu calon Presiden Indonesia 2024, Prabowo Subianto, yang dahulu dikenal sebagai sosok tegas dan berwibawa kini viral di media sosial dengan citra gemoy dan suka berjoget. Kontradiksi branding yang ditampilkan ini menarik untuk dieksplorasi lebih jauh terkait bagaimana strategi manajemen impresi yang dilakukannya dan bagaimana media digital berperan dalam proses tersebut. Teori Dramaturgi yang diperkenalkan Erving Goffman digunakan sebagai pendekatan untuk memahami fenomena ini. Penelitian ini menggunakan paradigma konstruktivis dengan pendekatan kualitatif berupa analisis teks dengan metode analisis multimodal. Dari hasil analisis didapatkan strategi yang digunakan dalam mengkonstruksikan citra baru Prabowo Subianto melalui media sosial. Penelitian ini juga membahas munculnya insiden dramaturgi yang mengganggu manajemen impresi yang telah dijalankan. Penelitian ini menunjukkan peran penting media digital yang dapat berdampak positif maupun negatif terhadap manajemen impresi. Selain itu, khalayak bukanlah objek pasif yang menerima begitu saja kesan yang diterima, tetapi dapat secara aktif mencari kebenaran dengan bantuan media digital. Peran khalayak dan media digital ini perlu dijadikan sebagai kajian dalam manajemen impresi, tidak hanya untuk mencegah munculnya insiden dramaturgi, tetapi juga menghadapi insiden dramaturgi yang telah telanjur terjadi.

One of the 2024 Indonesian presidential candidates, Prabowo Subianto, who was previously known as a firm and authoritative figure has now gone viral on social media with his cheerful image and likes dancing. This drastic change in the image is interesting to explore further to find out how impression management strategy is done and how digital media plays a role in this process. The Dramaturgical theory introduced by Erving Goffman is used as an approach to understanding this phenomenon. This research uses constructivist paradigm with qualitative approach in the form of text analysis with multimodal analysis methods. From the results of the analysis, the strategies used in constructing Prabowo Subianto's new image through social media were obtained. However, in the middle of implementing this strategy, dramaturgical incidents arose which disrupted the impression management that had been carried out. This research shows the important role of digital media which can have a positive or negative impact on the implementation of impression management. In addition, audiences are not passive objects who simply accept the impressions they receive, but can actively seek the truth with the help of digital media. The role of audiences and digital media needs to be used as a study in impression management, not only to prevent dramaturgical incidents from occurring, but also to deal with dramaturgical incidents that have already occurred. Thus, developing an impression management strategy should not only focus on how to construct the desired reality, but also how to prevent and act when dramaturgical incidents that disrupt impression management occur.
Daya Tarik Iklan dan Paid Promote Terhadap Minat Beli @sobatpromo
Authors: Girsang Lasmery , Situmeang Ilona 
Published: May 2024

Kegiatan pemasaran untuk menarik minat pembeli melalui media sosial senantiasa mengalami peningkatan. Salah satunya di instagram yang beriklan sesuai dengan target konsumen yang dituju dengan menggunakan daya Tarik iklan dan paid promote. Teori yang digunakan adalah Teori Elaborasi Kemungkinan, dengan tiga variabel yaitu Daya Tarik Iklan, Paid Promote dan Minat Beli. Paradigma dalam penelitian ini menggunakan Positivisme, dengan Pendekatan penelitian kuantitatif, Sifat penelitian eksplanatif dan Metode penelitian survey. Populasi dalam penelitian ini Followers dari @sobatpromo dengan menggunakan rumus slovin diperoleh 100 orang responden penelitian. Uji pretest menggunakan 30 responden untuk menjawab 22 item pertanyaan. Menguji tiga variabel: Daya Tarik Iklan, Paid Promo, dan Minat Beli follower @sobatpromo dengan Uji Korelasi Linear dan Berganda, Uji Regresi Berganda dan Uji Hipotesis dengan menggunakan Uji T dan Uji F. Hasil yang diperoleh terdapat pengaruh antara Daya Tarik Iklan dan Paid Promote secara bersama-sama terhadap Minat Beli. Menguji Teori Kemungkinan Elaborasi yang berisikan adanya dua jalur yakni rute utama dan rute pinggiran, didapatkan hasil penelitian dimana semua variabel diterima. Ditemukan bahwa responden memilih rute utama yakni memperoleh informasi secara langsung dari @sobatpromo yang tidak hanya berfokus pada isi pesan atau informasinya saja, melainkan memperhatikan aspek lain seperti penyampaian iklan, promosi yang ditawarkan, sound pada iklan dan hal lainnya.

Marketing activities to attract buyers' interest through social media are always increasing. One of them is on Instagram which advertises according to its target consumers using paid promos. Quantitative research–which applies SPSS as data analysis–got 100 respondents to answer 22 question items and tested three variables: advertising attractiveness, paid promo, and buying interest towards @sobatpromo followers. By testing the Elaboration Likelihood Model which contains two routes, namely the main route and the peripheral route, this research results that all variables were accepted. It was found that respondents chose the main route, in which obtaining the message directly from @sobatpromo; not only focused on the content of the message or information, but also paid attention to other aspects such as the delivery of the advertisement, the promotions offered, the sound of the advertisement and other things.
Democracy and Multicultural Education in Indonesia: A Bibliometric Study to Build Awareness and Collaborative Action
Authors: Rahmawati Siti , Tamami Fauziyah Qurrota Ayun , Tamami Sabrina Failasufa , Tamami Mochammad Mumtaz Rais 
Published: May 2024

With the use of bibliometric analysis drawn from several articles indexed in the Scopus database, this study seeks to map the evolution and direction of research on democracy and multicultural education to increase awareness and encourage collaborative action. The data found in levels from 1995 to 2024 will be analyzed to identify pertinent gaps. After that, the data was examined using R / R-Studio, VOSViewer, and Microsoft Excel software to identify keywords and document citation boosters. 193 publications that meet the established criteria, subject, and function were discovered by the researcher. This study's findings indicate a yearly increase rate. The scientific field and the annual quantity of studies published were taken into consideration when analyzing the obtained papers. This bibliometric analysis was restricted to data from Scopus. This study's drawback is that it only uses data sets or metadata from publications that are indexed in Scopus. In addition to offering suggestions for further research, this study gives a concise summary of the literature that scholars studying democracy and multicultural education for awareness-raising and collaborative action review can access.
PENGARUH PENAMBAHAN MOLASES, AMONIUM SULFAT, DAN DOLOMIT PADA SILASE PUCUK TEBU TERHADAP KANDUNGAN NDF DAN ADF
Authors: Riski Putra Suswanda Gede Bima , Muhtaruddin Muhtaruddin , Farda Fitria Tsani , Erwanto Erwanto 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui pengaruh penambahan molases, amonium sulfat, dan dolomit dengan level berbeda dan mengetahui level terbaik pemberian molases dan amonium sulfat pada silase pucuk tebu terhadap kandungan NDF dan ADF. Penelitian ini dilaksanakan pada bulan Mei – Agustus 2022 bertempat di PT. Gunung Madu Plantations, KM 90 Terbanggi Besar, Kabupaten Lampung Tengah, Provinsi Lampung. Analisis kandungan NDF dan ADF dilaksanakan di Laboratorium Pelayanan Kimia, Balai Penelitian Ternak, Bogor. Penelitian ini menggunakan metode eksperimental dengan Rancangan Acak Lengkap (RAL) yang terdiri dari 5 perlakuan dengan 5 ulangan, sehingga terdapat 25 unit percobaan. Perlakuan yang digunakan yaitu P1: silase pucuk tebu (molases 2,5% + amonium sulfat 1%), P2: silase pucuk tebu (molases 2,5% + amonium sulfat 2%), P3: silase pucuk tebu (molases 5% + amonium sulfat 1%), P4: silase pucuk tebu (molases 5% + amonium sulfat 2%), P5: silase pucuk tebu (molases 5% + amonium sulfat 2 + 2% dolomit). Data yang diperoleh dianalisis dengan analisis sidik ragam (ANOVA) dan dilanjutkan dengan Uji Lanjut Berganda Duncan. Hasil penelitian menunjukkan kandungan kandungan NDF (P1: 75,49%; P2: 73,77%; P3: 73,58%; P4: 71,46%; P5: 71,65%) berpengaruh sangat nyata (P<0,01) dan kandungan ADF (P1: 43,23%; P2: 42,23%; P3: 41,95%; P4: 42,28%; P5: 44,62%) berpengaruh nyata (P<0,05). Perlakuan P4 dengan penambahan molases 5% dan amonium sulfat 2% memberikan pengaruh terbaik (P<0,05%) terhadap kandungan NDF dan Perlakuan P3 dengan penambahan molases 5% dan amonium sulfat 1% memberikan pengaruh terbaik (P<0,05%) terhadap kandungan ADF.