bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS
Authors: Titulaer Maarten J. , Maddison Paul , Sont Jacob K. , Wirtz Paul W. , Hilton-Jones David , Klooster Rinse , Willcox Nick , Potman Marko , Smitt Peter A.E. Sillevis , Kuks Jan B.M. , Roep Bart O. , Vincent Angela , van der Maarel Silvère M. , van Dijk J. Gert , Lang Bethan , Verschuuren Jan J.G.M. 
Published: January 2011

Purpose Approximately one half of patients with Lambert-Eaton myasthenic syndrome (LEMS) have small-cell lung carcinomas (SCLC), aggressive tumors with poor prognosis. In view of its profound impact on therapy and survival, we developed and validated a score to identify the presence of SCLC early in the course of LEMS. Patients and Methods We derived a prediction score for SCLC in LEMS in a nationwide cohort of 107 Dutch patients, and validated it in a similar cohort of 112 British patients. A Dutch-English LEMS Tumor Association Prediction (DELTA-P) score was developed based on multivariate logistic regression. Results Age at onset, smoking behavior, weight loss, Karnofsky performance status, bulbar involvement, male sexual impotence, and the presence of Sry-like high-mobility group box protein 1 serum antibodies were independent predictors for SCLC in LEMS. A DELTA-P score was derived allocating 1 point for the presence of each of the following items at or within 3 months from onset: age at onset ≥ 50 years, smoking at diagnosis, weight loss ≥ 5%, bulbar involvement, erectile dysfunction, and Karnofsky performance status lower than 70. The area under the curve of the receiver operating curve was 94.4% in the derivation cohort and 94.6% in the validation set. A DELTA-P score of 0 or 1 corresponded to a 0% to 2.6% chance of SCLC, whereas scores of 4, 5, and 6 corresponded to chances of SCLC of 93.5%, 96.6%, and 100%, respectively. Conclusion The simple clinical DELTA-P score discriminated patients with LEMS with and without SCLC with high accuracy early in the course of LEMS.
Ranking Intervals and Dominance Relations for Ratio-Based Efficiency Analysis
Authors: Salo Ahti , Punkka Antti 
Published: January 2011

We develop comparative results for ratio-based efficiency analysis (REA) based on the decision-making units' (DMUs') relative efficiencies over sets of feasible weights that characterize preferences for input and output variables. Specifically, we determine (i) ranking intervals, which indicate the best and worst efficiency rankings that a DMU can attain relative to other DMUs; (ii) dominance relations, which show what other DMUs a given DMU dominates in pairwise efficiency comparisons; and (iii) efficiency bounds, which show how much more efficient a given DMU can be relative to some other DMU or a subset of other DMUs. Unlike conventional efficiency scores, these results are insensitive to outlier DMUs. They also show how the DMUs' efficiency ratios relate to each other for all feasible weights, rather than for those weights only for which the data envelopment analysis (DEA) efficiency score of some DMU is maximized. We illustrate the usefulness of these results by revisiting reported DEA studies and by describing a recent case study on the efficiency comparison of university departments. This paper was accepted by Teck-Hua Ho, decision analysis.
Applying a Biopsychosocial Perspective to Investigate Factors Related to Emotional Adjustment and Quality of Life for Individuals With Brain Tumour
Authors: Ownsworth Tamara , Hawkes Anna L. , Chambers Suzanne , Walker David G. , Shum David 
Published: January 2011

AbstractObjective:This exploratory study applied a biopsychosocial perspective to investigate cognitive and psychosocial factors related to emotional adjustment and QoL after brain tumour.Methods:Participants included 30 adults with a brain tumour (60% benign and 40% malignant) who were aged 28 to 71 years (M= 51.5,SD= 12.3) and on average 5.4 years post-diagnosis (SD= 5.6 years). Participants completed a brief battery of cognitive tests and self-report measures of emotional status (Depression, Anxiety Stress Scale), subjective impairment (Patient Competency Rating Scale), coping (COPE), social support (Brief Social Support Questionnaire), and QoL (Functional Assessment of Cancer Therapy — Brain Tumour [FACT-Br]).Results:QoL was significantly associated with global cognitive ability (r= .49,p< .01), subjective impairment (r= .66,p< .01), and satisfaction with support (r= .50,p< .05). Level of depressive symptoms was significantly correlated with premorbid IQ (r= -.49,p< .01), use of planning to cope (r= -.48,p< .01), and satisfaction with support (r= -.47,p< .01).Conclusions:Overall, these exploratory findings indicate that emotional adjustment and QoL after brain tumour is related to a slightly different pattern of neuropsychological, psychological (self-perceptions and coping) and social factors. The clinical implications for interventions with individuals with brain tumour are discussed.
Survival of Fish Impinged on a Rotary Disk Screen
Authors: Bigbee Daniel L. , King Ronald G. , Dixon Kent M. , Dixon Douglas A. , Perry Elgin S. 
Published: January 2011

Abstract
An impingement survival study was conducted to determine 48-h survival of fish impinged on a modified rotary disk screen equipped with fish protection features. The rotary disk screen was installed for a technology evaluation at the cooling-water intake structure of the North Omaha Station located on the Missouri River in Omaha, Nebraska. Hatchery-raised fish and native fish collected from the Missouri River were released in batches into the rotary disk screen bay and collected with a system that was constructed to recover fish from the screen's vacuum system. That system was designed to remove fish from the rotary disk screen and return them to the river. Screen performance was assessed in April and August, representing spring and summer environmental conditions. The 48-h survival rates of hatchery-raised fathead minnow Pimephales promelas, channel catfish Ictalurus punctatus, and bluegills Lepomis macrochirus and a group of mixed native species approached 100%. Survival rates were not statistically different between test groups and controls, indicating that impingement did not contribute to the observed mortality. High survival rates of impinged fish removed from the screen indicated that the rotary disk screen would reduce impingement losses at the North Omaha Station, where losses due to impingement on the existing vertical traveling screens are assumed by the U.S. Environmental Protection Agency to approach 100% because the screens lack fish protection features. Our study results suggest that the rotary disk screen tested could be considered an alternative technology under section 316(b) of the Clean Water Act, which requires power plants to install the best technology available to reduce impingement. Use of hatchery-reared fish and native fish collected from the river assured that an adequate number of fish were tested to provide statistically reliable results and allowed the use of controls to account for mortality due to handling stresses experienced by test fish.
Assessing the Effects of Catch-and-Release Regulations on a Brook Trout Population Using an Age-Structured Model
Authors: Risley Casey A. L. , Zydlewski Joseph 
Published: January 2011

Abstract
As populations of wild brook trout Salvelinus fontinalis decline across the species' native range in North America, angling regulations such as fly-fishing only and catch and release are being used by management agencies to conserve fish while maintaining angling opportunities. Postrelease (hooking) mortality may significantly shift the age structure and size structure of populations. To assess the possible influence of catch-and-release fishing on brook trout population structure, we applied data from several sources to build a deterministic population model that included age-classes up to age 5. To assess the potential effect of fishing, we examined the changes in population density and age structure at varying levels of angler effort (0–400 angler-hours·ha−1·year−1) and hooking mortality rates (0–14%). Assuming a low (5%) hooking mortality rate, trophy brook trout density (ages 4 and 5) decreased by 50% at an angling intensity of 160 angler-hours·ha−1·year−1. As angling effort increased, the proportion of older fish (ages 3–5) declined further. At very high levels of angling effort (&gt;300 angler-hours·ha−1·year−1), age-4 and age-5 fish were eliminated from the population. Increases in postrelease mortality rates resulted in similar declines for older age-classes. The results of this simulation indicate that hooking mortality rates as might be common in catch-and-release fisheries may significantly shift the age structure of a population, thus reducing trophy angling potential.
Estimating Changes in Coho Salmon and Steelhead Abundance from Watershed Restoration: How Much Restoration is Needed to Measurably Increase Smolt Production?
Authors: Roni Philip , Pess George , Beechie Tim , Morley Sarah 
Published: January 2011

Abstract
Using existing data from evaluations of habitat restoration, we estimated the average change in coho salmon Oncorhynchus kisutch and steelhead O. mykiss parr and smolt densities for common in-channel (culvert removal, large wood placement, boulder placement, and constructed logjams) and floodplain restoration techniques (constructed side channels and reconnected floodplain habitats). We then used these numbers and a Monte Carlo simulation to predict changes in fish numbers in a model watershed for two restoration scenarios: (1) restoration of all accessible habitat within the watershed and (2) restoration of the average amount historically implemented in Puget Sound watersheds (8% of total restorable areas). Mean increases in coho salmon parr or smolt density after restoration ranged from 0.19 to 2.32 parr/m for in-channel techniques and from 0.34 to 1.70 parr/m2 for floodplain techniques. Increases in steelhead parr or smolt density ranged from −0.06 to 0.71 fish/m and from 0.03 to 0.06 fish/m2 for in-channel and floodplain techniques, respectively. Under restoration scenario 1, the predicted mean increase in numbers was 1,459,254 (117%) and 285,302 (140%) for coho salmon parr and smolts and 93,965 (65%) and 28,001 (125%) for steelhead parr and smolts. Under scenario 2, the predicted mean increase in parr and smolts was 59,591 (5%) and 15,022 (7%) for coho salmon and 1,733 (1%) and 1,195 (5%) for steelhead. The percentage of floodplain and in-channel habitat that would have to be restored in the modeled watershed to detect a 25% increase in coho salmon and steelhead smolt production (the minimum level detectable by most monitoring programs) was 20%. However, given the large variability in fish response (changes in density or abundance) to restoration, 100% of the habitat would need to be restored to be 95% certain of achieving a 25% increase in smolt production for either species. Our study demonstrates that considerable restoration is needed to produce measurable changes in fish abundance at a watershed scale.
The Bioeconomic Impact of Different Management Regulations on the Chesapeake Bay Blue Crab Fishery
Authors: Bunnell David B. , Lipton Douglas W. , Miller Thomas J. 
Published: January 2011

Abstract
The harvest of blue crabs Callinectes sapidus in Chesapeake Bay declined 46% between 1993 and 2001 and remained low through 2008. Because the total market value of this fishery has declined by an average of US $ 3.3 million per year since 1993, the commercial fishery has been challenged to maintain profitability. We developed a bioeconomic simulation model of the Chesapeake Bay blue crab fishery to aid managers in determining which regulations will maximize revenues while ensuring a sustainable harvest. We compared 15 different management scenarios, including those implemented by Maryland and Virginia between 2007 and 2009, that sought to reduce female crab harvest and nine others that used seasonal closures, different size regulations, or the elimination of fishing for specific market categories. Six scenarios produced the highest revenues: the 2008 and 2009 Maryland regulations, spring and fall closures for female blue crabs, and 152- and 165-mm maximum size limits for females. Our most important finding was that for each state the 2008 and 2009 scenarios that implemented early closures of the female crab fishery produced higher revenues than the 2007 scenario, in which no early female closures were implemented. We conclude that the use of maximum size limits for female crabs would not be feasible despite their potentially high revenue, given the likelihood that the soft-shell and peeler fisheries cannot be expanded beyond their current capacity and the potentially high mortality rate for culled individuals that are the incorrect size. Our model results support the current use of seasonal closures for females, which permit relatively high exploitation of males and soft-shell and peeler blue crabs (which have high prices) while keeping the female crab harvest sustainable. Further, our bioeconomic model allows for the inclusion of an economic viewpoint along with biological data when target reference points are set by managers.
Development of Two New Sampling Techniques for Assessing Lake Trout Reproduction in Deep Water
Authors: Riley Jacob W. , Thompson Neil F. , Marsden J. Ellen , Janssen John 
Published: January 2011

Abstract
Efforts to restore lake trout Salvelinus namaycush at shallow sites have yielded minimal success in the lower four Great Lakes, and management agencies are examining offshore deepwater reefs as possible sites for restoration efforts. Previous techniques developed for assessing egg deposition and fry relative abundance in shallow waters are not viable for use on deep offshore reefs. To assess lake trout reproduction at deep reefs, two new methods (deepwater egg traps and remote electrofishing) were tested in Lake Champlain, Vermont. Deepwater egg traps were paired with buried egg bags to compare egg collections between the two types of gear at shallow sites in Lake Champlain. After testing, the new egg traps were deployed in Lake Michigan to quantify egg deposition at two sites within the Mid-Lake Reef Complex. There was a significant positive correlation between estimates of egg density in the paired deepwater traps and buried egg bags and no significant difference between egg densities in the two types of gear. In Lake Michigan, eggs were collected at depths greater than 35 m; the egg densities within the Mid-Lake Reef Complex were above or similar to egg densities at shallow sites in Lake Michigan. To assess fry relative abundance, a remotely operated electrofisher with video was tested on different densities and life stages of lake trout fry in the laboratory and was used to detect fry in Lake Champlain. The remote electrofisher detected fry in 90% of laboratory trials and 34–56% of field trials. Fry were vulnerable to the electrofisher at all developmental stages, and fry detection from the remote electrofisher was proportional to fry density in the laboratory and fry catch per unit effort from traditional emergent fry traps. These methods provide the potential to detect and quantify lake trout egg deposition and detect fry at deep offshore sites and may improve evaluation of the contribution of deep reefs to lake trout restoration.
Carcass Addition Does Not Enhance Juvenile Salmonid Biomass, Growth, or Retention in Six Northwestern California Streams
Authors: Harvey Bret C. , Wilzbach Margaret A. 
Published: January 2011

Abstract
Fisheries managers commonly consider the addition of salmon carcasses when seeking to enhance salmonid populations. However, the range of environmental conditions under which the technique is effective remains poorly defined. We addressed this issue by measuring the effects of wintertime addition of salmon carcasses on the biomass, growth, and retention of juvenile salmonids in an experiment that included two study reaches within each of six northwestern California streams. In the first 2 years of the study, half of the streams received carcasses in both study reaches; in the subsequent 2 years, we added carcasses only to the downstream reach in all six streams. For juvenile salmonid biomass, growth, and retention, the change in carcass distribution did not affect general patterns in the relationship of the upstream and downstream reaches within streams. Artificial addition of salmon carcasses during winter in streams similar to those we studied appears unlikely to benefit juvenile salmonids in the short-term; management alternatives focused on increasing escapement should probably take priority.
The Bioenergetic Consequences of Invasive-Induced Food Web Disruption to Lake Ontario Alewives
Authors: Stewart Thomas J. , O'Gorman Robert , Sprules W. Gary , Lantry B. F. 
Published: January 2011

Abstract
Alewives Alosa pseudoharengus are the dominant prey fish in Lake Ontario, and their response to ecological change can alter the structure and function of the Lake Ontario food web. Using stochastic population-based bioenergetic models of Lake Ontario alewives for 1987–1991 and 2001–2005, we evaluated changes to alewife production, consumption, and associated bioenergetic ratios after invasive-induced food web disruption. After the disruption, mean biomass of alewives declined from 28.0 to 14.6 g/m2, production declined from 40.8 to 13.6 g·m−2·year−1, and consumption declined from 342.1 to 137.2 g·m−2·year−1, but bootstrapping of error sources suggested that the changes were not statistically significant. Population-based bioenergetic ratios of production to biomass (P/B ratio), total consumption to biomass (Q/B ratio), and production efficiency did not change. Pathways of energy flow measured as prey-group-specific Q/B ratios changed significantly between the two time periods for invasive predatory cladocerans (from 0.6 to 1.3), Mysis diluviana (from 0.4 to 2.5), and other prey (from 0.8 to 0.1), but the observed decline in the zooplankton Q/B ratio (from 10.6 to 5.5) was not significant. Gross production efficiency did not change; values ranged from 8% to 15%. Age-group mean gross conversion efficiency (GCE) declined with age; GCE ranged from 7.5% to 11.0% for yearlings, was approximately 5% for age-2 alewives, and was less than 2% for age-3 and older alewives. The GCE increased significantly between the time periods for yearling alewives. Our analyses support the hypothesis that after 2003, alewives could not sustain their growth while feeding on zooplankton closer to shore. Modeling of observed spatial variation in diet and alternative occupied temperatures demonstrates the potential for reducing consumption by alewives. Our results suggest that Lake Ontario alewives can exploit spatial heterogeneity in resource patches and thermal habitat to partially mitigate the effects of food web disruption. Fish management implications are discussed.
Effectiveness of a Redesigned Water Diversion Using Rock Vortex Weirs to Enhance Longitudinal Connectivity for Small Salmonids
Authors: Martens Kyle D. , Connolly Patrick J. 
Published: January 2011

Abstract
For nearly 100 years, water diversions have affected fish passage in Beaver Creek, a tributary of the lower Methow River in north-central Washington State. From 2000 to 2004, four dam-style water diversions were replaced with a series of rock vortex weirs (RVWs). The weirs were designed to allow fish passage while maintaining the ability to divert water into irrigation canals. We observed the new appearance of three species (juvenile Chinook salmon Oncorhynchus tshawytscha, juvenile coho salmon O. kisutch, and mountain whitefish Prosopium williamsoni) upstream of the RVWs, indicating successful restoration of longitudinal connectivity. We used passive integrated transponder (PIT) tags and instream PIT tag interrogation systems during 2004–2007 to evaluate upstream passage of small salmonids (&lt;240 mm fork length) through one series of RVWs. We documented 109 upstream passage events by small salmonids through the series of RVWs; most of the events (81%) involved passage of rainbow trout O. mykiss or juvenile steelhead (anadromous rainbow trout). Small rainbow trout or steelhead ranging from 86 to 238 mm (adjusted fork length) were able to pass upstream through the RVWs, although a delay in fish passage at discharges below 0.32 m3/s was detected in comparison with nearby control sections.
Cyst acquisition rate for Giardia lamblia in backcountry travelers to Desolation Wilderness, Lake Tahoe
Authors: Zell S.C. , Sorenson S.K. 
Published: January 2011

The objective of this study was to determine the incidence of Giardia lamblia acquisition in back-country travelers to a wilderness area, provide longitudinal follow-up on the incidence of symptomatic gastrointestinal illness and relate such information to concentrations of Giardia cysts in water samples from a high-use area. A prospective cohort non-interventional study of 41 healthy adult backcountry travelers from age 19 to 71 years in Desolation Wilderness, Lake Tahoe Basin was carried out. The incidence of Giardia cyst acquisition in backcountry travelers was only 5.7% (95% CI 0.17–20.2%). Mild, self-limiting gastrointestinal illness occurred in 16.7% of subjects (95% CI 4.9%–34.50%), none of whom demonstrated G. lamblia infection. Water sampling from three popular stream sites revealed cyst contamination to be generally at low levels with cyst concentrations in the single digit range for every 100 gallons filtered. G. lamblia contamination of water occurs, but at low levels. Acquisition of this parasite may be infrequent in backcountry recreationalists. Symptomatic gastrointestinal illness following wilderness travel can be due to other etiologies. Our findings may not be representative of all wilderness areas, but suggest that in the absence of documented G. lamblia infection, persons symptomatic following travel may suffer a self-limiting gastrointestinal illness. In such circumstances, empiric therapy for giardiasis is tempting but difficult to justify.
Incidence and severity of middle ear barotrauma in recreational scuba diving
Authors: Green Steven M. , Rothrock Steven G. , Hummel Christopher B. , Green Elizabeth A. 
Published: January 2011

This prospective observational study was designed to assess the incidence and severity of middle ear barotrauma associated with repetitive recreational scuba diving. Eleven healthy adult experienced scuba divers were observed performing repetitive daily scuba diving over a 15 day period. Otoscopy and tympanometry were performed on days 0, 3, 7, 11 and 15. Participants averaged 41 dives during the study period. Mild otalgia occurred at some point in 23% of ears and subsequently resolved in all but one despite continued diving. Eight-two per cent of ears demonstrated otoscopic evidence of middle ear barotrauma by day 3, and all exhibited barotrauma by day 11. Tympanic membrane perforation, hemotympanum, or evidence of inner ear barotrauma did not occur. Tympanometry revealed a significant decrease in middle ear pressures but no evidence of middle ear effusions. Gross measurements of otologic acuity and conduction remained normal. No complications or sequelae were noted at three month follow-up. Otoscopic evidence of middle ear barotrauma and tympanometric evidence of eustachian tube dysfunction developed rapidly in a group of experienced scuba divers performing repetitive recreational diving. Symptoms were minimal and infrequent. No serious otologic dysfunction was noted despite continued repetitive diving, and it is possible that middle ear barotrauma at the degrees observed represents a more benign disorder than has been previously assumed.