bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relating the Phases of Magnetic Reconnection Growth to Energy Transport Mechanisms in the Exhaust
Authors: Payne D. S. , Torbert R. B. , Germaschewski K. , Forbes T. G. , Shuster J. R. 
Published: May 2024

AbstractThe efficiency of energy conversion during magnetic reconnection is related to the reconnection rate. While the stable reconnection rate has been studied extensively, its growth between the time of reconnection onset and its peak has not been thoroughly discussed. We use a 2D particle‐in‐cell simulation to examine how the reconnection rate evolves during the growth process and how it relates to changes near the x‐line. We identify three phases of growth: (a) slow quasi‐linear growth, (b) rapid exponential growth, and (c) tapered growth followed by negative growth after the reconnection rate peaks. We associate phase 1 with the breaking of x‐line uniformity by a localized density depletion that changes the in‐plane electric field structure near the neutral line, followed by the expansion of the inflow region and the enhancement of inflow Poynting flux Sz associated with the out‐of‐plane electric field Ey in phase 2. We show how the Hall fields facilitate rapid growth in phase 2 by opening up the exhaust and relieving the electron‐scale bottleneck to allow rapid energy transport across the separatrices. We find that in phase 3, the inflow of electromagnetic energy accumulates until the downstream electromagnetic energy density saturates toward the initial upstream asymptotic value. Finally, we examine how the electron outflow and the downstream ion populations interact in phase 3 and how each species exchanges energy with the local field structures in the exhaust.
The Seasonal Dependence of the Unexpected Afternoon Westward Equatorial Electrojet During Quiet Time
Authors: Zhang Kedeng , Wang Hui , Song Huimin , Zhong Yunfang , Xia Hao , Sun Yu , Wang Chengzhi 
Published: May 2024

AbstractThe equatorial electrojet is a strong ionospheric current along the dip equator at 110 km. It usually flows eastward and peaks at noon. However, it sometimes reverses westward. Using 10 years of horizontal geomagnetic field observations from a ground station, this work investigated the counter electrojet (CEJ) in the afternoon at Indian longitudes during geomagnetically quiet time, which has a substantial occurrence rate of 46.7%. A total of 41.7% of the afternoon CEJ is related to the westward electric field during substorms. The intensity of the afternoon CEJ has significant seasonal dependences: peaks in June‐September and December‐February. A similar seasonal variation is established in the westward electric field, indicating its key roles. The occurrence rate reaches its peak solely in June‐September, which might also be attributed to the activity of substorms.
Biomass Burning Greatly Enhances the Concentration of Fine Carbonaceous Aerosols at an Urban Area in Upper Northern Thailand: Evidence From the Radiocarbon‐Based Source Apportionment on Size‐Resolved Aerosols
Authors: Song Wenhuai , Hong Yihang , Zhang Yuxian , Cao Fang , Rauber Martin , Santijitpakdee Teetawat , Kawichai Sawaeng , Prapamontol Tippawan , Szidat Sönke , Zhang Yan‐Lin 
Published: May 2024

AbstractTo study the role of biomass burning (BB) in air pollution at upper‐northern Thailand, the source apportionment of size‐resolved carbonaceous aerosols from Chiang Mai was carried out based on the radiocarbon (14C) analysis. The fraction of modern carbon (F14C) was generally decreased with particle size increasing and with the highest and lowest values of 0.90 ± 0.04 and 0.61 ± 0.04, respectively. Elemental carbon, regardless of emission sources, and BB‐derived organic carbon (OCbb) showed unimodal size distribution patterns with peaks at 0.43–0.65 μm. Fossil‐fuel derived‐OC (OCf) displayed a bimodal mode with the major peak at 2.1–10 μm, and the minor one at 0.43–0.65 μm. The biogenic secondary organic aerosols (BSOA) showed a typical fine‐mode unimodal size distribution pattern during the high BB (HBB) season, and a bimodal mode during the low BB season. The BSOA concentration increased by 189% ± 80% due to the interaction with open BB plums during HBB season, which was quantified by a 14C‐involved random forest model. Besides, the concentration of biogenic primary organic aerosols also showed a significant increment during the HBB season, especially in sub‐microns. Our results highlight the critical importance of controlling open fires to reduce air pollutants and the potential exposure risk.
Alkyl Lipid Distributions and Compound‐Specific 14C Isotope Compositions in Diverse Sedimentary Archives in Sub‐Antarctic South Georgia: Deconvolving (Past and Present) Marine and Terrestrial Sources and Revealing Localized Export Dynamics in Response to Environmental Change
Authors: Berg S. , Kusch S. , Jivcov S. 
Published: May 2024

AbstractAlkyl lipid distributions in terrestrial, lacustrine and marine sedimentary archives on sub‐Antarctic South Georgia are investigated to identify source endmembers and evaluate their variation in response to Holocene environmental changes. To understand organic matter exchange processes along the land‐ocean continuum, we combine lipid compositional data with compound‐specific 14C data in representative sedimentary records. These data provide additional source information and temporal constraints on exchange processes that operate at the landscape level. The alkane, alkanoic acid and alkanol distributions are distinct between terrestrial and marine sources, between vascular and primarily non‐vascular plants, and according to the level of degradation. Compound‐specific 14C ages of alkanes, alkanoic acids and alkanols reveal the complexity of the carbon pools associated with these carbon sources. We find that terrigenous compounds in lacustrine and marine sediments are generally older than those produced by aquatic sources, reflecting intermediate storage in peat/soil prior to deposition. Nonetheless, the pre‐depositional age of terrigenous alkyl lipids differs in the different settings although they are located in close proximity under the same climatic conditions. Overall, the 14C data reflect changes in the balance of accumulation and erosion of organic matter in the terrestrial catchments of the investigated sites in response to prevailing environmental conditions. Petrogenic OC ranges from 0% to 7% and 4%–37% in catchments with minor glacier presence and to up to 67%–76% in the large tidewater glacier catchment. Long‐term biospheric OC turnover seems to have been remarkably constant throughout most of the Holocene and higher than in analog settings in the northern hemisphere.
Polymeric piezoelectric accelerometers with high sensitivity, broad bandwidth, and low noise density for organic electronics and wearable microsystems
Authors: Ge Chang , Cretu Edmond 
Published: May 2024

AbstractPiezoelectric accelerometers excel in vibration sensing. In the emerging trend of fully organic electronic microsystems, polymeric piezoelectric accelerometers can be used as vital front-end components to capture dynamic signals, such as vocal vibrations in wearable speaking assistants for those with speaking difficulties. However, high-performance polymeric piezoelectric accelerometers suitable for such applications are rare. Piezoelectric organic compounds such as PVDF have inferior properties to their inorganic counterparts such as PZT. Consequently, most existing polymeric piezoelectric accelerometers have very unbalanced performance metrics. They often sacrifice resonance frequency and bandwidth for a flat-band sensitivity comparable to those of PZT-based accelerometers, leading to increased noise density and limited application potentials. In this study, a new polymeric piezoelectric accelerometer design to overcome the material limitations of PVDF is introduced. This new design aims to simultaneously achieve high sensitivity, broad bandwidth, and low noise. Five samples were manufactured and characterized, demonstrating an average sensitivity of 29.45 pC/g within a ± 10 g input range, a 5% flat band of 160 Hz, and an in-band noise density of 1.4 µg/$$\sqrt{{Hz}}$$Hz. These results surpass those of many PZT-based piezoelectric accelerometers, showing the feasibility of achieving comprehensively high performance in polymeric piezoelectric accelerometers to increase their potential in novel applications such as organic microsystems.
RUFY4 deletion prevents pathological bone loss by blocking endo-lysosomal trafficking of osteoclasts
Authors: Kim Minhee , Park Jin Hee , Go Miyeon , Lee Nawon , Seo Jeongin , Lee Hana , Kim Doyong , Ha Hyunil , Kim Taesoo , Jeong Myeong Seon , Kim Suree , Kim Taesoo , Kim Han Sung , Kang Dongmin , Shim Hyunbo , Lee Soo Young 
Published: May 2024

AbstractMature osteoclasts degrade bone matrix by exocytosis of active proteases from secretory lysosomes through a ruffled border. However, the molecular mechanisms underlying lysosomal trafficking and secretion in osteoclasts remain largely unknown. Here, we show with GeneChip analysis that RUN and FYVE domain-containing protein 4 (RUFY4) is strongly upregulated during osteoclastogenesis. Mice lacking Rufy4 exhibited a high trabecular bone mass phenotype with abnormalities in osteoclast function in vivo. Furthermore, deleting Rufy4 did not affect osteoclast differentiation, but inhibited bone-resorbing activity due to disruption in the acidic maturation of secondary lysosomes, their trafficking to the membrane, and their secretion of cathepsin K into the extracellular space. Mechanistically, RUFY4 promotes late endosome-lysosome fusion by acting as an adaptor protein between Rab7 on late endosomes and LAMP2 on primary lysosomes. Consequently, Rufy4-deficient mice were highly protected from lipopolysaccharide- and ovariectomy-induced bone loss. Thus, RUFY4 plays as a new regulator in osteoclast activity by mediating endo-lysosomal trafficking and have a potential to be specific target for therapies against bone-loss diseases such as osteoporosis.
Ring-opening polymerization of six-membered cyclic hybrid dimers composed of an oxoester and thioester
Authors: Hirata Mao , Yoshimatsu Tomoki , Matsuoka Shin-ichi , Kawauchi Susumu , Suzuki Masato 
Published: May 2024

AbstractThree cyclic oxoester-thioester hybrid monomers, 1 (3-methyl-1,4-oxathiane-2,5-dione), 2 (6-methyl-1,4-oxathiane-2,5-dione), and 3 (3,6-dimethyl-1,4-oxathiane-2,5-dione), were studied for anionic and cationic ring-opening polymerizations. These monomers are six-membered cyclic cross-dimers corresponding to combinations of glycolic and lactic acids with their thiol analogs. Anionic polymerizations using thiol as the initiator and 2,6-lutidine as the base catalyst were successful for the chemoselective cleavage of the thioester with the thiol propagating end. The polymerizability increased in the order of 3 < 1 < 2, which was in good agreement with the increasing ring strain order evaluated by Density Functional Theory calculations. The living character, to some extent, was suggested by the postpolymerization reactions, which involved a two-stage feed of the monomers and a thiol-ene terminal coupling reaction to form a block copolymer with PEG. Additionally, it was found that the polymerization took place in 2,6-lutidine without a thiol initiator and produced macrocyclic polymers. The cationic polymerizations took place with the aid of CF3SO3H and benzyl alcohol but involved side reactions with low chemoselective ring cleavage. The thioester unit caused the polymers to exhibit a lower Tg with greater thermal and photo degradability.
Redox-induced controllable engineering of MnO2-MnxCo3-xO4 interface to boost catalytic oxidation of ethane
Authors: Wang Haiyan , Wang Shuang , Liu Shida , Dai Yiling , Jia Zhenghao , Li Xuejing , Liu Shuhe , Dang Feixiong , Smith Kevin J. , Nie Xiaowa , Hou Shuandi , Guo Xinwen 
Published: May 2024

AbstractMulticomponent oxides are intriguing materials in heterogeneous catalysis, and the interface between various components often plays an essential role in oxidations. However, the underlying principles of how the hetero-interface affects the catalytic process remain largely unexplored. Here we report a unique structure design of MnCoOx catalysts by chemical reduction, specifically for ethane oxidation. Part of the Mn ions incorporates with Co oxides to form spinel MnxCo3-xO4, while the rests stay as MnO2 domains to create the MnO2-MnxCo3-xO4 interface. MnCoOx with Mn/Co ratio of 0.5 exhibits an excellent activity and stability up to 1000 h under humid conditions. The synergistic effects between MnO2 and MnxCo3-xO4 are elucidated, in which the C2H6 tends to be adsorbed on the interfacial Co sites and subsequently break the C-H bonds on the reactive lattice O of MnO2 layer. Findings from this study provide valuable insights for the rational design of efficient catalysts for alkane combustion.
Experimental demonstration of an on-chip p-bit core based on stochastic magnetic tunnel junctions and 2D MoS2 transistors
Authors: Daniel John , Sun Zheng , Zhang Xuejian , Tan Yuanqiu , Dilley Neil , Chen Zhihong , Appenzeller Joerg 
Published: May 2024

AbstractProbabilistic computing is a computing scheme that offers a more efficient approach than conventional complementary metal-oxide–semiconductor (CMOS)-based logic in a variety of applications ranging from optimization to Bayesian inference, and invertible Boolean logic. The probabilistic bit (or p-bit, the base unit of probabilistic computing) is a naturally fluctuating entity that requires tunable stochasticity; by coupling low-barrier stochastic magnetic tunnel junctions (MTJs) with a transistor circuit, a compact implementation is achieved. In this work, by combining stochastic MTJs with 2D-MoS2 field-effect transistors (FETs), we demonstrate an on-chip realization of a p-bit building block displaying voltage-controllable stochasticity. Supported by circuit simulations, we analyze the three transistor-one magnetic tunnel junction (3T-1MTJ) p-bit design, evaluating how the characteristics of each component influence the overall p-bit output. While the current approach has not reached the level of maturity required to compete with CMOS-compatible MTJ technology, the design rules presented in this work are valuable for future experimental implementations of scaled on-chip p-bit networks with reduced footprint.
Sustained bacterial N2O reduction at acidic pH
Authors: He Guang , Chen Gao , Xie Yongchao , Swift Cynthia M. , Ramirez Diana , Cha Gyuhyon , Konstantinidis Konstantinos T. , Radosevich Mark , Löffler Frank E. 
Published: May 2024

AbstractNitrous oxide (N2O) is a climate-active gas with emissions predicted to increase due to agricultural intensification. Microbial reduction of N2O to dinitrogen (N2) is the major consumption process but microbial N2O reduction under acidic conditions is considered negligible, albeit strongly acidic soils harbor nosZ genes encoding N2O reductase. Here, we study a co-culture derived from acidic tropical forest soil that reduces N2O at pH 4.5. The co-culture exhibits bimodal growth with a Serratia sp. fermenting pyruvate followed by hydrogenotrophic N2O reduction by a Desulfosporosinus sp. Integrated omics and physiological characterization revealed interspecies nutritional interactions, with the pyruvate fermenting Serratia sp. supplying amino acids as essential growth factors to the N2O-reducing Desulfosporosinus sp. Thus, we demonstrate growth-linked N2O reduction between pH 4.5 and 6, highlighting microbial N2O reduction potential in acidic soils.
Macro-scale relationship between body mass and timing of bird migration
Authors: Wang Xiaodan , Somveille Marius , Dokter Adriaan M. , Cao Wenhua , Cheng Chuyu , Liu Jiajia , Ma Zhijun 
Published: May 2024

AbstractClarifying migration timing and its link with underlying drivers is fundamental to understanding the evolution of bird migration. However, previous studies have focused mainly on environmental drivers such as the latitudes of seasonal distributions and migration distance, while the effect of intrinsic biological traits remains unclear. Here, we compile a global dataset on the annual cycle of migratory birds obtained by tracking 1531 individuals and 177 populations from 186 species, and investigate how body mass, a key intrinsic biological trait, influenced timings of the annual cycle using Bayesian structural equation models. We find that body mass has a strong direct effect on departure date from non-breeding and breeding sites, and indirect effects on arrival date at breeding and non-breeding sites, mainly through its effects on migration distance and a carry-over effect. Our results suggest that environmental factors strongly affect the timing of spring migration, while body mass affects the timing of both spring and autumn migration. Our study provides a new foundation for future research on the causes of species distribution and movement.
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Authors: Jiang Dadi , Guo Youming , Wang Tianyu , Wang Liang , Yan Yuelong , Xia Ling , Bam Rakesh , Yang Zhifen , Lee Hyemin , Iwawaki Takao , Gan Boyi , Koong Albert C. 
Published: May 2024

AbstractCellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer and normal cells depleted of IRE1α gain resistance to ferroptosis, while enhanced IRE1α expression promotes sensitivity to ferroptosis. Mechanistically, IRE1α’s endoribonuclease activity cleaves and down-regulates the mRNA of key glutathione biosynthesis regulators glutamate-cysteine ligase catalytic subunit (GCLC) and solute carrier family 7 member 11 (SLC7A11). This activity of IRE1α is independent of its role in regulating the UPR and is evolutionarily conserved. Genetic deficiency and pharmacological inhibition of IRE1α have similar effects in inhibiting ferroptosis and reducing renal ischemia–reperfusion injury in mice. Our findings reveal a previously unidentified role of IRE1α to regulate ferroptosis and suggests inhibition of IRE1α as a promising therapeutic strategy to mitigate ferroptosis-associated pathological conditions.
The origin of exceptionally large ductility in molybdenum alloys dispersed with irregular-shaped La2O3 nano-particles
Authors: Chen Yujie , Fang Yan , Cheng Pengming , Ke Xiaoxing , Zhang Manchen , Zou Jiawei , Ding Jun , Zhang Bozhao , Gu Lin , Zhang Qinghua , Liu Gang , Yu Qian 
Published: May 2024

AbstractMolybdenum and its alloys are known for their superior strength among body-centered cubic materials. However, their widespread application is hindered by a significant decrease in ductility at lower temperatures. In this study, we demonstrate the achievement of exceptional ductility in a Mo alloy containing rare-earth La2O3 nanoparticles through rotary-swaging, a rarity in Mo-based materials. Our analysis reveals that the large ductility originates from substantial variations in the electronic density of states, a characteristic intrinsic to rare-earth elements. This characteristic can accelerate the generation of oxygen vacancies, facilitating the amorphization of the oxide-matrix interface. This process promotes vacancy absorption and modification of dislocation configurations. Furthermore, by inducing irregular shapes in the La2O3 nanoparticles through rotary-swaging, incoming dislocations interact with them, creating multiple dislocation sources near the interface. These dislocation sources act as potent initiators at even reduced temperatures, fostering diverse dislocation types and intricate networks, ultimately enhancing dislocation plasticity.
CEA-CD3 bispecific antibody cibisatamab with or without atezolizumab in patients with CEA-positive solid tumours: results of two multi-institutional Phase 1 trials
Authors: Segal Neil H. , Melero Ignacio , Moreno Victor , Steeghs Neeltje , Marabelle Aurelien , Rohrberg Kristoffer , Rodriguez-Ruiz Maria E. , Eder Joseph P. , Eng Cathy , Manji Gulam A. , Waterkamp Daniel , Leutgeb Barbara , Bouseida Said , Flinn Nick , Das Thakur Meghna , Elze Markus C. , Koeppen Hartmut , Jamois Candice , Martin-Facklam Meret , Lieu Christopher H. , Calvo Emiliano , Paz-Ares Luis , Tabernero Josep , Argilés Guillem 
Published: May 2024

AbstractCibisatamab is a bispecific antibody-based construct targeting carcinoembryonic antigen (CEA) on tumour cells and CD3 epsilon chain as a T-cell engager. Here we evaluated cibisatamab for advanced CEA-positive solid tumours in two open-label Phase 1 dose-escalation and -expansion studies: as a single agent with or without obinutuzumab in S1 (NCT02324257) and with atezolizumab in S2 (NCT02650713). Primary endpoints were safety, dose finding, and pharmacokinetics in S1; safety and dose finding in S2. Secondary endpoints were anti-tumour activity (including overall response rate, ORR) and pharmacodynamics in S1; anti-tumour activity, pharmacodynamics and pharmacokinetics in S2. S1 and S2 enrolled a total of 149 and 228 patients, respectively. Grade ≥3 cibisatamab-related adverse events occurred in 36% of S1 and 49% of S2 patients. The ORR was 4% in S1 and 7% in S2. In S2, patients with microsatellite stable colorectal carcinoma (MSS-CRC) given flat doses of cibisatamab and atezolizumab demonstrated an ORR of 14%. In S1 and S2, 40% and 52% of patients, respectively, developed persistent anti-drug antibodies (ADAs). ADA appearance could be mitigated by obinutuzumab-pretreatment, with 8% of patients having persistent ADAs. Overall, cibisatamab warrants further exploration in immunotherapy combination strategies for MSS-CRC.
Inverted device architecture for high efficiency single-layer organic light-emitting diodes with imbalanced charge transport
Authors: Tan Xiao , Dou Dehai , Chua Lay-Lay , Png Rui-Qi , Congrave Daniel G. , Bronstein Hugo , Baumgarten Martin , Li Yungui , Blom Paul W. M. , Wetzelaer Gert-Jan A. H. 
Published: May 2024

AbstractMany wide-gap organic semiconductors exhibit imbalanced electron and hole transport, therefore efficient organic light-emitting diodes require a multilayer architecture of electron- and hole-transport materials to confine charge recombination to the emissive layer. Here, we show that even for emitters with imbalanced charge transport, it is possible to obtain highly efficient single-layer organic light emitting diodes (OLEDs), without the need for additional charge-transport and blocking layers. For hole-dominated emitters, an inverted single-layer device architecture with ohmic bottom-electron and top-hole contacts moves the emission zone away from the metal top electrode, thereby more than doubling the optical outcoupling efficiency. Finally, a blue-emitting inverted single-layer OLED based on thermally activated delayed fluorescence is achieved, exhibiting a high external quantum efficiency of 19% with little roll-off at high brightness, demonstrating that balanced charge transport is not a prerequisite for highly efficient single-layer OLEDs.