bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Machine Learning Approach toward Cyber-Physical Security of Battery Systems
Authors: Srinath Srikanth , Dey Satadru 
Published: June 2024

Abstract
Modern battery systems exhibit a cyber-physical nature due to the extensive use of communication technologies in battery management. This makes modern cyber-physical battery systems vulnerable to cyber threats where an adversary can manipulate sensing and actuation signals to satisfy certain malicious objectives. In this work, we present a machine learning-based approach to enable resilience to adversarial attacks by detecting and estimating the attack and subsequently taking corrective action to mitigate the attack. In particular, we focus on false data injection type attacks on battery systems. The overall diagnostic algorithm consists of an adaptive boosting-based attack detector, a long short-term memory (LSTM) neural network-based attack estimator, and a corrective controller. The proposed algorithm is trained and tested by utilizing data from a complex battery electrochemical battery simulator. Simulation results are presented to verify the effectiveness of the approach.
A Dynamic Discrete Model of Ventilated Concrete Floor Integrated With Solar Air Collector Under the Effect of Uneven Direct Solar Radiation
Authors: Luo Xiujing , Yu Tao , Liu Xicheng , Lei Bo , Zheng Jiacheng 
Published: June 2024

Abstract
A system combining the ventilated concrete floor (VCF) with solar air collector (SAC) in buildings has been applied in the western Sichuan Plateau for nighttime heating. However, the dynamic model coupled with uneven solar radiation of SAC-VCF is absent, thus the thermal behavior of the system is difficult to predict in practice. In this research, a coupled model is built to predict the thermal characteristics of the room with the SAC-VCF system under uneven solar radiation. The calculation model of VCF considers the uneven distribution of solar radiation on the floor surface, established by combining the resistance–capacitance (RC) network model and the number of transfer unit (NTU) model using the discrete method and validated by experimental data. A 3R2C model is utilized to model envelopes, validated by simulation results. The calculation error of surface temperature and room air temperature is within 5%. Then a case study is conducted with the validated model to predict the thermal performance of the SAC-VCF system with even and uneven solar radiation. Results indicate that under uneven solar radiation, the local surface temperature significantly increases to 35.1 °C, 9.1 °C higher than even solar radiation. Meanwhile, under uneven solar radiation, the heat transfer of supply air and surface of VCF is increased by 14% and 6%, respectively. Besides, the room air temperature is almost equal of two cases, while the operative temperature is 0.4 °C lower under uneven solar radiation. The model is beneficial to further study the influencing factors of this system.
Treatment exit options for non-infectious uveitis registry: participant characteristics at 3 years
Authors: Fink David Julian , Dell Jennifer , Heinz Carsten , Wintergerst Maximilian W M , Höller Tobias , Berger Moritz , Schmid Matthias , Boden Karl Thomas , Pleyer Uwe , Reitsamer Herbert , Deuter Christoph M E , Lohmann Tibor K , Finger Robert P 
Published: June 2024

Purpose
The Treatment exit Options For non-infectious Uveitis (TOFU) registry documents disease courses for non-anterior non-infectious uveitis entities with and without treatment to generate more evidence for clinical management recommendations including treatment exit strategies. In this article, we present the participants’ baseline characteristics after the first 3 years.

Methods
TOFU is an observational, prospective registry and recruits patients ≥18 years of age with non-anterior non-infectious uveitis with or without a history of previous disease-modifying antirheumatic drugs (DMARDs) treatment. The data are collected in the electronic data capture software REDCap and include ophthalmological and general medical history as well as clinical findings.

Results
Between 24.10.2019 and 27.12.2022, 628 patients were enrolled at 25 clinical sites in Germany and Austria. Patients with intermediate uveitis were most frequently included (n=252; 40.1%) followed by posterior uveitis (181; 28.8%), panuveitis (n=154; 24.5%) and retinal vasculitis (n=41, 6.5%). At baseline, 39.6% were treated with systemic corticosteroids, 22.3% with conventional synthetic (cs) DMARDs, 20.5% with biological (b) DMARDs and 3.6% with other systemic treatments. Average best corrected visual acuity (BCVA) was 0.69 decimal. Patients with panuveitis had the worst BCVA with 0.63 decimal. Overall, only 8 patients (1.3%) suffered from severe visual impairment.

Conclusions
Less than half of participants required DMARD treatment at baseline, with csDMARDs used more frequently than bDMARDs. The presence of severe visual impairment was low, mostly affecting patients with panuveitis. These findings are in line with comparable monocentric cross-sectional studies of tertiary uveitis centres in Germany and will allow us to generate generalisable evidence in TOFU.
Clinical decision aids and computed tomography coronary angiography in patients with suspected acute coronary syndrome
Authors: Wang Kang-Ling , Taggart Caelan , McDermott Michael , O'Brien Rachel , Oatey Katherine , Keating Liza , Storey Robert F , Felmeden Dirk , Curzen Nick , Kardos Attila , Roobottom Carl , Smith Jason , Goodacre Steve , Newby David E , Gray Alasdair J 
Published: June 2024

Background
The HEART score, the T-MACS model and the GRACE score support early decision-making for acute chest pain, which could be complemented by CT coronary angiography (CTCA). However, their performance has not been directly compared.

Methods
In this secondary analysis of a multicentre randomised controlled trial of early CTCA in intermediate-risk patients with suspected acute coronary syndrome, C-statistics and performance metrics (using the predefined cut-offs) of clinical decision aids and CTCA, alone and then in combination, for the index hospital diagnosis of acute coronary syndrome and for 30-day coronary revascularisation were assessed in those who underwent CTCA and had complete data.

Results
Among 699 patients, 358 (51%) had an index hospital diagnosis of acute coronary syndrome, for which the C-statistic was higher for CTCA (0.80), followed by the T-MACS model (0.78), the HEART score (0.74) and the GRACE score (0.60). The negative predictive value was higher for the absence of coronary artery disease on CTCA (0.90) or a T-MACS estimate of <0.05 (0.83) than a HEART score of <4 (0.81) and a GRACE score of <109 (0.55). For 30-day coronary revascularisation, CTCA had the greatest C-statistic (0.80) with a negative predictive value of 0.96 and 0.92 in the absence of coronary artery disease and obstructive coronary artery disease, respectively. The combination of the T-MACS estimates and the CTCA findings was most discriminative for the index hospital diagnosis of acute coronary syndrome (C-statistic, 0.88) and predictive of 30-day coronary revascularisation (C-statistic, 0.85). No patients with a T-MACS estimate of <0.05 and normal coronary arteries had acute coronary syndrome during index hospitalisation or underwent coronary revascularisation within 30 days.

Conclusions
In intermediate-risk patients with suspected acute coronary syndrome, the T-MACS model combined with CTCA improved discrimination of the index hospital diagnosis of acute coronary syndrome and prediction of 30-day coronary revascularisation.

Trial registration number

NCT02284191
.
PARP-1 selectively impairsKRAS-driven phenotypic and molecular features in intrahepatic cholangiocarcinoma
Authors: Keggenhoff Friederike L , Castven Darko , Becker Diana , Stojkovic Stojan , Castven Jovana , Zimpel Carolin , Straub Beate K , Gerber Tiemo , Langer Harald , Hähnel Patricia , Kindler Thomas , Fahrer Jörg , O'Rourke Colm J , Ehmer Ursula , Saborowski Anna , Ma Lichun , Wang Xin Wei , Gaiser Timo , Matter Matthias S , Sina Christian , Derer Stefanie , Lee Ju-Seog , Roessler Stephanie , Kaina Bernd , Andersen Jesper B , Galle Peter R , Marquardt Jens U 
Published: June 2024

ObjectiveIntrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer with limited therapeutic options.KRASmutations are among the most abundant genetic alterations in iCCA associated with poor clinical outcome and treatment response. Recent findings indicate that Poly(ADP-ribose)polymerase1 (PARP-1) is implicated inKRAS-driven cancers, but its exact role in cholangiocarcinogenesis remains undefined.DesignPARP-1inhibition was performed in patient-derived and established iCCA cells using RNAi, CRISPR/Cas9 and pharmacological inhibition inKRAS-mutant, non-mutant cells. In addition,Parp-1knockout mice were combined with iCCA induction by hydrodynamic tail vein injection to evaluate an impact on phenotypic and molecular features ofKras-driven andKras-wildtype iCCA. Clinical implications were confirmed in authentic human iCCA.ResultsPARP-1 was significantly enhanced inKRAS-mutant human iCCA. PARP-1-based interventions preferentially impaired cell viability and tumourigenicity in humanKRAS-mutant cell lines. Consistently, loss ofParp-1provoked distinct phenotype inKras/Tp53-induced versusAkt/Nicd-induced iCCA and abolishedKras-dependent cholangiocarcinogenesis. Transcriptome analyses confirmed preferential impairment of DNA damage response pathways and replicative stress response mediated by CHK1. Consistently, inhibition of CHK1 effectively reversed PARP-1 mediated effects. Finally,Parp-1depletion induced molecular switch ofKRAS-mutant iCCA recapitulating good prognostic human iCCA patients.ConclusionOur findings identify the novel prognostic and therapeutic role ofPARP-1in iCCA patients with activation of oncogenicKRASsignalling.
Association of childhood food consumption and dietary pattern with cardiometabolic risk factors and metabolomics in late adolescence: prospective evidence from ‘Children of 1997’ birth cohort
Authors: He Baoting , Lam Hugh Simon , Sun Yangbo , Kwok Man Ki , Leung Gabriel M , Schooling C Mary , Au Yeung Shiu Lun 
Published: June 2024

Background
Healthy diet might protect against cardiometabolic diseases, but uncertainty exists about its definition and role in adolescence.

Method
In a subset of Hong Kong’s ‘Children of 1997’ birth cohort (n=2844 out of 8327), we prospectively examined sex-specific associations of food consumption and dietary pattern, proxied by the Global Diet Quality Score (GDQS) at~12.0 years, with cardiometabolic risk factors and metabolomics at~17.6 years.

Result
Higher vegetable (−0.04 SD, 95% CIs: −0.09 to 0.00) and soy consumption (−0.05 SD, 95% CI: −0.09 to −0.01) were associated with lower waist-to-hip ratio. Higher fruit and vegetable consumption were associated with lower fasting glucose (p<0.05). Higher fish consumption was associated with 0.06 SD (95% CI: 0.01 to 0.10) high-density lipoprotein cholesterol and −0.07 SD (95% CI: −0.11 to −0.02) triglycerides. After correcting for multiple comparisons (p<0.001), higher fish, fruit and vegetable consumption were associated with higher fatty acid unsaturation, higher concentration and percentage of omega-3 and a lower ratio of omega-6/omega-3. At nominal significance (p<0.05), higher fish consumption was associated with lower very-low-density lipoprotein and triglycerides relevant metabolomics. Higher vegetable and fruit consumption were associated with lower glycolysis-related metabolomics. Lower sugar-sweetened beverages (SSBs) consumption was associated with lower branched-chain amino acids. Similar associations with adiposity and metabolomics biomarkers were observed for GDQS.

Conclusions
Higher consumption of fruit, vegetables and fish and lower ice cream and SSBs consumption were associated with lower cardiometabolic risk in adolescents.
Abstract A001: KIF18A inhibition, via ATX020, leads to mitotic arrest and robust anti-tumor activity through a synthetic lethal interaction with chromosome instability
Authors: Lynes* Maureen S. , Ghisolfi† Laura , Khan Sanjoy , Hotz Taylor , Sparling Brian A. , Zablocki Mary-Margaret , Gotur Deepali , Boriack-Sjodin P. Ann , Duncan Kenneth W. , Blakemore Stephen J. , Silver Serena J. , Copeland Robert A 
Published: June 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR001) of the Conference Program/Proceedings.
Citation Format: Maureen S. Lynes, Laura Ghisolfi, Sanjoy Khan, Taylor Hotz, Brian A. Sparling, Mary-Margaret Zablocki, Deepali Gotur, P. Ann Boriack-Sjodin, Kenneth W. Duncan, Stephen J. Blakemore, Serena J. Silver, Robert A Copeland. KIF18A inhibition, via ATX020, leads to mitotic arrest and robust anti-tumor activity through a synthetic lethal interaction with chromosome instability [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr A001.
Abstract A005: A live cell PRMT5 NanoBRET™ target engagement assay querying competitive and uncompetitive modes of inhibition
Authors: Teske Kelly A. , Michaud Ani , Rothweiler Elisabeth , Corona Cesear , Hoffman Kaitlin Dunn , Wilkinson Jennifer , Beck Michael , Vasta James , Huber Kilian , Robers Matthew 
Published: June 2024

Abstract
PRMT5 is an essential arginine methyltransferase that regulates a wide spectrum of cellular processes through the methylation of histone and non-histone substrates. In PRMT5 catalysis, SAM serves as the cofactor and methyl group donor, generating a methylated guanidinium moiety on the target substrate. In normal cells, the SAM pools are maintained through the methionine salvage pathway. In 15% of cancers, a key enzyme in this pathway (MTAP) is deleted, leading to an accumulation of the intermediate MTA, which inhibits PRMT5 activity. This genetic loss of function has therefore been pursued as a collateral vulnerability in MTAP deleted cancers. To exploit this synthetic lethality, a number of novel inhibitors (such as MRTX1719) have been developed that bind cooperatively at the PRMT5/MTA complex, offering a compelling pathway to precision medicine. Here we describe a novel, live cell NanoBRET™ Target Engagement assay that enables mechanistic studies on a variety of PRMT5 inhibitors. Using a cell-permeable NanoBRET probe directed to the substrate pocket of PRMT5, both substrate- and cofactor-competitive engagement can be quantified in cells. Moreover, this method can be used to quantify MTA-uncompetitive target engagement in cells, providing a platform to measure the potency of PRMT5-MTA-drug ternary complex formation. This method serves as a first-in-class method to quantify uncompetitive target engagement in live cells, which can be applied to other model systems.
Citation Format: Kelly A. Teske, Ani Michaud, Elisabeth Rothweiler, Cesear Corona, Kaitlin Dunn Hoffman, Jennifer Wilkinson, Michael Beck, James Vasta, Kilian Huber, Matthew Robers. A live cell PRMT5 NanoBRET™ target engagement assay querying competitive and uncompetitive modes of inhibition [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr A005.
Abstract A011: Enhancing chaperone-mediated autophagy to impede glioblastoma growth
Authors: Tang Wanjun , Yee Kiang Karrie Mei , Kit Leung Gilberto Ka 
Published: June 2024

Abstract
Chaperone-mediated autophagy (CMA) is a selective form of autophagy that targets proteins with the KFERQ-like motif for lysosomal degradation. This process involves the binding of substrate proteins to the chaperone HSC70 and their subsequent transport to the receptor LAMP2A on the lysosome membrane for degradation. Previous studies have shown a significant increase in the expression level of LAMP2A and the CMA activity in glioblastoma (GBM). However, the comprehensive role of CMA in GBM pathogenesis remains unclear. In this study, we observed a progressive elevation in LAMP2A expression with increasing GBM cell confluence. Notably, inhibition of CMA through LAMP2A knockdown markedly promoted GBM growth in orthotopic mouse models, accompanied by upregulation of positive cell cycle regulators. Conversely, overexpression of LAMP2A delayed GBM cell growth and increased sub-G1 cell percentages. Treatment with CMA activators induced cell death in GBM cells while preserving normal astrocyte viability at equivalent concentrations. Our results suggest that the upregulated expression of LAMP2A in GBM cells may be influenced by the tumor microenvironment rather than being a primary driver of GBM aggressiveness. Furthermore, activating CMA could serve as a potential therapeutic strategy to inhibit GBM growth while safeguarding normal cell viability.
Citation Format: Wanjun Tang, Karrie Mei Yee Kiang, Gilberto Ka Kit Leung. Enhancing chaperone-mediated autophagy to impede glioblastoma growth [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr A011.
Abstract A016: Companion Diagnostics (CDx) to identify hallmarks of Alternative Lengthening of Telomeres (ALT)
Authors: Kadamur Ganesh , Tarantino Dalia , Grogono Freddie , Von Morgen Patrick , Tammaccaro Salvina , Zatreanu Diana , Canova Donata Federici , Wolf Jana , van den Kieboom Corne , Chapman Katie , Schuurmans Joris , Moll Jurgen 
Published: June 2024

Abstract
Maintenance of telomeres in the absence of telomerase is known as Alternative Lengthening of Telomeres (ALT), which is prevalent in 10-15% of all cancers. Tessellate BIO targets ALT mechanisms to drive cell death by synthetic lethality. To identify patients who will benefit from our therapy, we are developing companion diagnostics (CDx). In this study, established hallmarks of ALT are investigated as CDx target in tissue-derived samples. In fresh and FFPE tumor tissue, presence and abundance of different ALT hallmarks were measured, including RPA phosphorylation, C-circles and telomeric single stranded DNA. While not all markers pass the stringent requirements of a CDx, C-circles prove to be a reliable biomarker. To measure C-circles, a robust and scalable PCR-based protocol was developed, facilitating easy implementation in the clinic. Utilizing this protocol, C-circles were successfully measured across different tissue types. Further, the protocol allowed for C-circle quantification in cell lines, showcasing its utility across matrices of varying complexity. Successful development of the C-circle CDx enables patients selection based on ALT mechanisms herewith improving the response rate of targeted therapies in patients and accelerating new discoveries in the ALT space.
Citation Format: Ganesh Kadamur, Dalia Tarantino, Freddie Grogono, Patrick Von Morgen, Salvina Tammaccaro, Diana Zatreanu, Donata Federici Canova, Jana Wolf, Corne van den Kieboom, Katie Chapman, Joris Schuurmans, Jurgen Moll. Companion Diagnostics (CDx) to identify hallmarks of Alternative Lengthening of Telomeres (ALT) [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr A016.
Abstract A026: Single-cell landscape deciphering cancer Single-cell landscape deciphering cancer cell-of-origin and cellular heterogeneity in malignant transformation of 13 major tissues
Authors: Luo Ruihan 
Published: June 2024

Abstract
Deciphering disease progression and the sophisticated tumor ecosystems is imperative for exploring tumorigenesis mechanisms and developing novel prevention strategies. Here, we dissected heterogeneous tissue microenvironments during malignant transitions by leveraging data from 4,972,145 single cells in 1396 samples from 62 datasets spanning 13 major tissue types. Within transitional stem-like subpopulations highly enriched in precancerous lesions and cancers, we identified 30 recurring cellular states, including hypoxia and epithelial senescence, revealing a high degree of plasticity in epithelial stem cells. By characterizing the dynamics of stem-cell crosstalk with the microenvironment along the pseudotime axis, we uncovered distinct roles of ANXA1 at different stages of tumor development. ANXA1 expression levels in stem cells were decreased from the healthy to the precancerous stages, which promoted inflammatory responses by recruiting neutrophils and regulating monocyte differentiation towards M1 macrophages. In contrast, during malignant progression, upregulated ANXA1 fostered M2 macrophage polarization and cancer-associated fibroblast transformation. Our spatiotemporal analysis further provided insights into mechanisms responsible for immunosuppression. Collectively, this study provided a systematic view of cancer origins, and suggested that restoring and maintaining the balance of inflammation and their mediators (e.g., AnxA1/FPRs signaling) may represent a novel approach to control the evolution of precancerous lesions and mitigate the risk for cancer development.
Citation Format: Ruihan Luo. Single-cell landscape deciphering cancer cell-of-origin and cellular heterogeneity in malignant transformation of 13 major tissues [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr A026.
Abstract B023: Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer
Authors: Li Peng , Zhen Yuanli , Kim Chiho , Liu Zhengshuai , Hao Jianwei , Deng Heping , Deng Hejun , Zhou Min , Wang Xu-Dong , Qin Tian , Yu Yonghao 
Published: June 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR002) of the Conference Program/Proceedings.
Citation Format: Peng Li, Yuanli Zhen, Chiho Kim, Zhengshuai Liu, Jianwei Hao, Heping Deng, Hejun Deng, Min Zhou, Xu-Dong Wang, Tian Qin, Yonghao Yu. Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr B023.