bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wavelet–ANN hybrid model evaluation in seepage prediction in nonhomogeneous earthen dams
Authors: Fatehi-Nobarian Bahador , Fard Moradinia Sina 
Published: June 2024

ABSTRACT

In this study, novel methods such as wavelet–artificial neural network hybrid models and artificial neural network models were used to predict seepage from the Zonouz earthen dam. The dataset consisted of 972 piezometric data points. Statistical fitting methods such as root mean squared error, determination coefficient, scatter plots, and data distribution diagrams were used to evaluate the results. The findings indicated that the wavelet–artificial neural network hybrid model was more accurate than the artificial neural network model. Specifically, during training, the wavelet–artificial neural network hybrid model had determination coefficients and root mean squared errors of 0.820, 0.680, 743.39, and 792.52, while the artificial neural network model had 0.700, 0.600, 426.39, and 131.45. Similarly, during validation, the wavelet–artificial neural network hybrid model had determination coefficients and root mean squared errors of 0.700, 0.600, 426.39, and 131.45, while the artificial neural network model had 0.823, 0.680, 743.39, and 792.52. Therefore, the wavelet–artificial neural network hybrid model can be proposed as a precise method for predicting seepage in earthen dams and is more accurate than the artificial neural network model. This study highlights the importance of preventing dam failures and using advanced modeling techniques for better predictions and preventive measures.
Numerical simulation of flow characteristics in nonprismatic compound channels
Authors: Kaushik Vijay , Kumar Munendra , Naik Bandita 
Published: June 2024

ABSTRACT

The assessment of the flow characteristics of river systems is a very intricate undertaking in the development of hydraulic models for the purposes of flood control and floodplain management. Therefore, it is essential to use simulation models in order to calibrate and verify the experimental results. In this study, the Hydrologic Engineering Centre's – River Analysis System (HEC-RAS) is used to calibrate and validate the distribution of velocity and shear stress for different converging compound channels. Two separate flow regimes were assessed for validation based on experimental data obtained from converging compound channels with angles of θ = 5°, 9°, and 12.38°. The projected values for two relative depths (β = 0.15 and 0.20) exhibit a similar pattern of variation as the empirical observations and are marginally lower than the recorded values. This suggests that the HEC-RAS model accurately estimates the velocity and shear stress values. The disparity between the simulated and experimental outcomes shows a discrepancy of less than 10%. Hence, the implications of our results suggest that while dealing with nonprismatic rivers, it is advisable to take into account lower values. The used methodology and the outcomes focused on problem-solving might potentially inform the development of flood control infrastructure for nonprismatic watercourses.
Treatment of tetracycline in an aqueous solution with an iron–biochar/periodate system: Influencing factors and mechanisms
Authors: Xu Shuo , Wei Hongyan , Li Xuejiao , Chen Lizhu , Song Tiehong 
Published: June 2024

ABSTRACT

In this study, a potassium ferrate (K2FeO4)-modified biochar (Fe–BC) was prepared and characterized. Afterwards, Fe–BC was applied to activated periodate (PI) to degrade tetracycline (TC), an antibiotic widely used in animal farming. The degradation effects of different systems on TC were compared and the influencing factors were investigated. In addition, several reactive oxygen species (ROS) generated by the Fe–BC/PI system were identified, and TC degradation pathways were analyzed. Moreover, the reuse performance of Fe–BC was evaluated. The results exhibited that the Fe–BC/PI system could remove almost 100% of TC under optimal conditions of [BC] = 1.09 g/L, initial [PI] = 3.29 g/L, and initial [TC] = 20.3 mg/L. Cl−, HCO3−, NO3−, and humic acid inhibited TC degradation to varying degrees in the Fe–BC/PI system due to their quenching effects on ROS. TC was degraded into intermediates and even water and carbon dioxide by the synergistic effect of ROS generated and Fe on the BC surface. Fe–BC was reused four times, and the removal rate of TC was still maintained above 80%, indicating the stable nature of Fe–BC.
Computational Investigation of Novel Compounds as Dual Inhibitors of
AChE and GSK-3β for the Treatment of Alzheimer's Disease
Authors: Londhe Saurabh G. , Shenoy Mangala , Kini Suvarna G. , Walhekar Vinayak , Kumar Dileep 
Published: June 2024

Background:
Alzheimer's disease (AD) stands out as one of the most devastating and
prevalent neurodegenerative disorders known today. Researchers have identified several enzymatic
targets associated with AD among which Glycogen synthase kinase-3β (GSK-3β) and Acetylcholinesterase
(AChE) are prominent ones. Unfortunately, the market offers very few drugs for
treating or managing AD, and none have shown significant efficacy against it.

Objectives:
To address this critical issue, the design and discovery of dual inhibitors will represent
a potential breakthrough in the fight against AD. In the pursuit of designing novel dual inhibitors,
we explored molecular docking and dynamics analyses of tacrine and amantadine uredio-linked
amide analogs such as GSK-3β and AChE dual inhibitors for curtailing AD. Tacrine and adamantine
are the FDA-approved drugs that were structurally modified to design and develop novel drug
candidates that may demonstrate concurrently dual selectivity towards GSK-3β and AChE.

Methods:
In the following study, molecular docking was executed by employing AutoDock Vina,
and molecular dynamics and ADMET predictions were made using Desmond, Qikprop modules
of Schrödinger.

Results:
Our findings revealed that compounds DST2 and DST11 exhibited remarkable molecular
interactions with active sites of GSK-3β and AChE, respectively. These compounds effectively interacted
with key amino acids, namely Lys85, Val135, Asp200, and Phe295, resulting in highly
favourable docking energies of -9.7 and -12.7 kcal/mol. Furthermore, through molecular dynamics
simulations spanning a trajectory of 100 ns, we confirmed the stability of ligands DST2 and
DST11 within the active cavities of GSK-3β and AChE. The compounds exhibiting the most
promising docking results also demonstrated excellent ADMET profiles. Notably, DST21 displayed
an outstanding human oral absorption rate of 76.358%, surpassing the absorption rates of
other molecules.

Conclusion:
Overall, our in-silico studies revealed that the designed molecules showed potential
as novel anti-Alzheimer agents capable of inhibiting both GSK-3β and AChE simultaneously. So,
in the future, the designing and development of dual inhibitors will harbinger a new era of drug design
in AD treatment.
A Narrative Overview of Coronavirus Infection: Clinical Signs and Symptoms, Viral Entry and Replication, Treatment Modalities, and Management
Authors: Chavda Vishal , Yadav Dhananjay , Parmar Harisinh , Brahmbhatt Raxit , Patel Bipin , Madhwani Kajal , Jain Meenu , Song Minseok , Patel Snehal 
Published: June 2024

:
The global pandemic known as coronavirus disease (COVID-19) is causing morbidity
and mortality on a daily basis. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-
-2) virus has been around since December 2019 and has infected a high number of patients due to
its idiopathic pathophysiology and rapid transmission. COVID-19 is now deemed a newly identified
“syndrome” condition since it causes a variety of unpleasant symptoms and systemic side effects
following the pandemic. Simultaneously, it always becomes potentially hazardous when new
variants develop during evolution. Its random viral etiology prevents accurate and suitable therapy.
Despite the fact that multiple preclinical and research studies have been conducted to combat
this lethal virus, and various therapeutic targets have been identified, the precise course of therapy
remains uncertain. However, just a few drugs have shown efficacy in treating this viral infection
in its early stages. Currently, several medicines and vaccinations have been licensed following
clinical trial research, and many countries are competing to find the most potent and effective immunizations
against this highly transmissible illness. For this narrative review, we used PubMed,
Google Scholar, and Scopus to obtain epidemiological data, pre-clinical and clinical trial outcomes,
and recent therapeutic alternatives for treating COVID-19 viral infection. In this study, we
discussed the disease's origin, etiology, transmission, current advances in clinical diagnostic technologies,
different new therapeutic targets, pathophysiology, and future therapy options for this devastating
virus. Finally, this review delves further into the hype surrounding the SARS-CoV-2 illness,
as well as present and potential COVID-19 therapies.
Evaluating the Preliminary Effectiveness of the Person-Centered Care Assessment Tool (PCC-AT) in Zambian Health Facilities: Protocol for a Mixed Methods Cross-Sectional Study
Authors: Posner Jessica , Ndhlovu Adamson Paxon , Musangulule Jemmy Mushinka , Duffy Malia , Casella Amy , Madevu-Matson Caitlin , Davis Nicole , Sharer Melissa 
Published: June 2024

Background
Person-centered care (PCC) within HIV treatment services has demonstrated potential to overcome inequities in HIV service access while improving treatment outcomes. Despite PCC being widely considered a best practice, no consensus exists on its assessment and measurement. This study in Zambia builds upon previous research that informed development of a framework for PCC and a PCC assessment tool (PCC-AT).

Objective
This mixed methods study aims to examine the preliminary effectiveness of the PCC-AT through assessing the association between client HIV service delivery indicators and facility PCC-AT scores. We hypothesize that facilities with higher PCC-AT scores will demonstrate more favorable HIV treatment continuity, viral load (VL) coverage, and viral suppression in comparison to those of facilities with lower PCC-AT scores.

Methods
We will implement the PCC-AT at 30 randomly selected health facilities in the Copperbelt and Central provinces of Zambia. For each study facility, data will be gathered from 3 sources: (1) PCC-AT scores, (2) PCC-AT action plans, and (3) facility characteristics, along with service delivery data. Quantitative analysis, using STATA, will include descriptive statistics on the PCC-AT results stratified by facility characteristics. Cross-tabulations and/or regression analysis will be used to determine associations between scores and treatment continuity, VL coverage, and/or viral suppression. Qualitative data will be collected via action planning, with detailed notes collected and recorded into an action plan template. Descriptive coding and emerging themes will be analyzed with NVivo software.

Results
As of May 2024, we enrolled 29 facilities in the study and data analysis from the key informant interviews is currently underway. Results are expected to be published by September 2024.

Conclusions
Assessment and measurement of PCC within HIV treatment settings is a novel approach that offers HIV treatment practitioners the opportunity to examine their services and identify actions to improve PCC performance. Study results and the PCC-AT will be broadly disseminated for use among all project sites in Zambia as well as other HIV treatment programs, in addition to making the PCC-AT publicly available to global HIV practitioners.

International Registered Report Identifier (IRRID)
DERR1-10.2196/54129
Aprendizaje-Servicio como instrumento para incorporar la Agenda 2030 en las universidades
Authors: Amiano Iratxe , Gezuraga Monike , Alonso-Sáez Israel 
Published: June 2024

Existe consenso en afirmar que las instituciones de educación superior deben participar como agentes activos en la consecución de la Agenda 2030, poniendo todas sus misiones al servicio de la sociedad. Esto requiere una transformación de la política universitaria en el marco de su responsabilidad social, que afecta de manera significativa al ámbito de la formación y exige un mayor compromiso con la satisfacción de las necesidades sociales. El objetivo de esta investigación consiste en demostrar que el Aprendizaje-Servicio es una propuesta que aporta valor a la sociedad por su alto potencial formador y por promover la construcción de conocimiento de forma colaborativa entre agentes educativos y sociales. La metodología utilizada consistió en la revisión sistemática, de la literatura académica contenida en bases de datos de referencia y de los proyectos llevados a cabo en Europa y América Latina en el ámbito universitario. Como resultado, se presentan evidencias de que el Aprendizaje-Servicio es una metodología válida para que las universidades participen en la consecución de cada uno de los Objetivos de Desarrollo Sostenible.
Pengaruh penggunaan model pembelajaran PjBL terhadap keterampilan kolaborasi siswa pada pembelajaran IPA di kelas VI SD Inpres 1 Tanamodindi
Authors: Pendit Sinta Satria Dewi , Zulnuraini  , Azizah  , Handayani Ni Putu Devi 
Published: June 2024

Tujuan penelitian ini yaitu untuk mengetahui ada tidaknya pengaruh penggunaan model pembelajaran Project Based Learning terhadap keterampilan kolaborasi siswa pada pembelajaran IPA di kelas VI SD Inpres 1 Tanamodindi. Jenis penelitian yang digunakan adalah quasi eksperimen dengan nonequivalent control group design. Sampel dalam penelitian ini yaitu siswa kelas VI SD Inpres 1 Tanamodindi yang berjumlah 52 orang. Siswa kelas eksperimen berjumlah 26 orang dan siswa kelas kontrol berjumlah 26 orang. Pengambilan data yang dilakukan menggunakan angket kolaborasi siswa. Analisis data yang dilakukan terdiri atas uji normalitas, uji homogenitas dan uji hipotesis dengan berbantuan program IBM SPSS Statistics 23. Berdasarkan pengujian hipotesis menggunakan uji paired sample T test pada taraf nyata 5% (0,05) diperoleh nilai signifikan 0,000 maka hasil penelitian ini menunjukkan hasil nilai signifikan 0,000 < 0,05 maka Ho (hipotesis nol) ditolak dan Ha (hipotesis alternatif) diterima. Sehingga dapat disimpulkan bahwa ada pengaruh penggunaan model pembelajaran Project Based Learning terhadap keterampilan kolaborasi siswa pada pembelajaran IPA di kelas VI SD Inpres 1 Tanamodindi.
Learning Text Analytics: An Analysis of MD&A Disclosures during the Pandemic
Authors: Cheng Christine , Jones Lynn Comer , Mohapatra Partha 
Published: June 2024

ABSTRACT
Not all relevant data come in structured formats. We created this teaching case to introduce students to an important data analysis technique that can be used on unstructured data: text analytics. This case focuses on why MD&A disclosures may provide auditors, regulators, and investors with decision-relevant information during the global pandemic. There are a wide variety of tools that can be used to introduce accounting students to text analytics. In the Teaching Notes, we provide instructions for Alteryx, a technology that offers a low-code solution to text analytics. Low-code solutions allow faculty and students to focus on critical thinking and applying text analytics to accounting. The learning objectives are (1) expand students’ understanding of text analytics in an accounting setting, (2) develop students’ skills necessary for performing text analytics, and (3) expand students’ critical thinking skills as they apply text analytics in accounting or business contexts.
Data Availability: Data are available from public sources cited in the text and materials that are available for download.
Navigating Unprecedented Times: How Managers’ Empathetic Adjustments in a Crisis Influence Employee Effort in a Competitive Environment
Authors: Berger Leslie , Guo Lan , Wick Sara 
Published: June 2024

ABSTRACT
When organizational crises arise, one way that managers can help employees cope is to provide empathetic adjustments, where managers adjust downward performance expectations for all employees while communicating the adjustment with empathy. In a competitive environment, we explore whether providing an empathetic adjustment to employees during a crisis affects their postcrisis effort. We conduct an experiment and observe that an empathetic adjustment significantly improves the postcrisis effort of top and bottom performers. The increase in postcrisis effort of top performers can be attributed to the effect of the adjustment, whereas the increase in postcrisis effort of bottom performers can be attributed to the effect of empathy. In a supplemental survey, we find a range of positive effects of empathetic adjustment, including increased engagement, reduced burnout, and lower turnover intentions.
Data Availability: Data are available from the authors upon request.
JEL Classifications: G31; G32; G33; M21.
Improving Supply Security: Guidelines and Policy Proposals
Authors: Felbermayr Gabriel , Janeba Eckhard 
Published: June 2024

Abstract
Supply security is threatened by technical, business, natural and policy shocks, as well as geopolitical tensions. Is there a rationale for policy intervention? If yes, what are efficient and effective measures that achieve de-risking? This article first explains why private incentives do not generally lead to an optimal diversification of supply sources, and then discusses measures that strengthen protection against and resilience in the face of shocks. Governments should refrain from policies that further disincentivise diversification such as the ex post skimming of excess profits when adverse shocks force the halt of production and should work on framework conditions that facilitate diversification. Importantly, most measures are best taken at the EU level.
Climate Change in the EU’s Macroeconomic Imbalance Procedure
Authors: Hungerland Wolf-Fabian , Altmeppen Christoph 
Published: June 2024

Abstract
EU member states observe an elaborate process to preserve macroeconomic stability: the macroeconomic imbalance procedure (MIP). The MIP is supposed to monitor and prevent macroeconomic imbalances – and if necessary, correct them. It considers a variety of variables to determine the existence of imbalances, e.g. the current account balance or unit labour costs. However, the macroeconomic impact of climate change is ignored. In light of the growing economic risks due to climate change, this article argues that the MIP should consider climate-related risks explicitly to maintain relevance.
Constitutional Rights and Obligations of Citizens Towards the Environment Under the Conditions of Sustainable Development
Authors: Zębek Elżbieta 
Published: June 2024

Abstract
The aim of this article is to determine the status of citizen’s rights to ‘a clean environment’ and their obligations towards the environment under sustainable development conditions, considering international and domestic regulations. It analyses three interlinked aspects: human rights to a clean environment, obligations of citizens and public authorities towards the environment, and environmental protection in accordance with the principle of sustainable development. Human rights to ‘a clean environment’ are enshrined in the Constitution, drawing on the Universal Declaration of Human Rights and the Rio de Janeiro ‘Environment and Development’ Declaration. These rights are implemented by public authorities through ensuring ecological safety and the use and protection of environmental resources, adhering to the sustainable development principle. In addition every citizen has obligations towards the environment, because he should take care of environmental resources and use them in accordance with the principles of environmental protection law. The analysis of legal doctrine and legislation highlights a clear relationship between the necessity for public authorities to ensure constitutional rights to a ‘clean environment’ and their obligations towards the environment through the protection of environmental resources in line with the sustainable development principle. This entails balancing the human right to a ‘clean environment’ against the environmental right to the continuity and sustainability of resources (natural balance), while also ensuring economic growth. An example of these principles in action is Agenda 2030, currently being implemented in Poland and other EU Member States.
Gloss on the Judgement of the Supreme Administrative Court of 21 October 2022, III OSK 4468/211 (Concerning the Provision of Public Information by a Foundation)
Authors: Szustakiewicz Przemysław 
Published: June 2024

Abstract
In its judgment of 21 October 2022, III OSK 4468/21, the Supreme Administrative Court considered that a foundation is obliged to provide public information because, in accordance with Article 1 of the Act on Foundations, it should accomplish socially and economically useful objectives that comply with the interests of the Republic of Poland. These are objectives that should also be accomplished by public administration; thus, they are, in fact, the State’s objectives. In such a situation, the Court decided that the informative obligation of foundations that are not public law entities applies, in fact, to every aspect of their activities. This should be recognised as correct, because the constitution-maker specified in Article 61(1) of the Constitution of the Republic of Poland a very broad range of entities obliged to provide public information, ensuring that every field of the State’s activity is transparent.
Communities and Partnerships of Independent Management Consultants - The Path to Professional Success
Authors: Lobanova Tatiana 
Published: June 2024

Abstract
The paper presents an analysis of the possibilities for developing a community of independent management consultants and forming partnerships in conditions of global uncertainty. The purpose of the study was to show the core of activity, level of competencies and uniqueness of knowledge of the management consultants’ community; determine its growth points. Individual consultants from the National Institute of Certified Management Consultants of Russia (NICMC), Fifty eight consultants took part in the study as a sample. Using the author’s questionnaire, it was possible to identify perspective areas of community development strategies and partnerships for consultants that allow them to achieve greater success in consulting.
The anticoagulant treatment dilemma in pulmonary embolism associated to cancer
Authors: Nemtut Daniela Maria , Petreanu Cornel Adrian , Ulmeanu Ruxandra 
Published: June 2024

Abstract
Pulmonary embolism (PE) is defined by the obstruction of pulmonary arteries by thrombi or emboli (malignant, grease, air). Most frequently, thrombi arise from deep veins of lower limbs. Pulmonary embolism is a medical emergency with a high death risk. Early mortality is high, sudden death occurs in about a quarter of the patients. On long term, it can lead to post-embolic pulmonary hypertension and recurrent pulmonary embolia. The high risk of death in acute phase and on long-term depends on the severity of the acute phase, on the recurrence, and on the co-morbidities. PE can be the first manifestation of on occult malignancy, or it may complicate an already diagnosed cancer.
We present a retrospective analysis on PE associated to malignancy, on 106 patients, with classic anticoagulant treatment (low weight molecule heparin and/or antivitamin K agents) or novel oral anticoagulants (NOAC) and compare the early and late mortality associated to PE and anticoagulant treatment. Our observations note a higher percentage of recurrences but significantly lower mortality in patients treated with NOAC as compared to classic treatments.