bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and 1H NMR titration study of 7‐deoxycholic amide or cholane ionophores containing different ion‐recognizing groups at C3 and C12
Authors: Oh Hyunju , Han Sang Keun , Kim Byeong Hyo 
Published: January 2012

AbstractTweezer‐type ionophores containing C3‐carbamoylpropanamidoacetoxy and C12‐dithiocarbamoyl groups on a 7‐deoxycholic amide or cholane derivative were designed and synthesized. A representative 1H NMR titration study indicated that newly synthesized ionophores form 1:1 complexes with the Ca2 + ion. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 23:187–194, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21002
Efficient growth suppression and apoptosis in human laryngeal carcinoma cell line HEP‐2 induced by an adeno‐associated virus expressing human FAS ligand
Authors: Sun Haili , Liu Yuhe , Bu Dingfang , Liu Xiang , Norris James S. , Xiao Shuifang 
Published: January 2012

AbstractBackgroundApoptosis induced by Fas/FasL system has been proposed as a gene therapy methold for various cancers.MethodsWe used adeno‐associated virus–expressing enhanced green fluorescent protein (EGFP)‐human FasL (AAV‐EGFP‐hFasL) to deliver FasL into Hep‐2 cells, cytotoxicity was detected by MTS assay , apoptosis was confirmed by flow cytometry. We also treated the xenograft of Hep‐2 tumor in nude mice with intratumoral injection of AAV‐EGFP‐hFasL. The size of the xenograft, the apoptosis in the xenograft, and the survival rate of the inoculated mice were then evaluated.ResultsHep‐2 cells infected with AAV‐EGFP‐hFasL showed increased apoptosis rate and killing effect compared with AAV‐EGFP–infected cells. In addition intratumoral injections of AAV‐EGFP‐hFasL into Hep‐2 xenografts induced significant growth suppression of tumors.ConclusionOur findings suggest that the introduction of FasL into head and neck squamous cell carcinoma may induce significant apoptosis, and adeno‐associated virus may be a useful vehicle for gene therapy. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Plastic cordotomy in the treatment of bilateral vocal fold immobility
Authors: Yagudin Ramil K. , Demenkov Valentin R. , Yagudin Kamil F. 
Published: January 2012

AbstractBackgroundThe purpose of this study was to evaluate a new surgical method, plastic cordotomy for treatment of bilateral vocal fold immobility.MethodsWe used cadaver experiments on 20 larynges to measure the widening of the glottis after bilateral plastic cordotomy. We conducted a prospective study of 21 female patients operated on with bilateral plastic cordotomy.ResultsBilateral plastic cordotomy enlarged the width of glottis to 9.55 (range, 8.3–10) mm in men and 8.5 (range, 7.4–8.8) mm in women and the area of glottis to 110.5 mm2 (range, 88–149 mm2) in men and to 84.5 mm2 (range, 59–107 mm2) in women. Clinical study revealed that the mean of peak inspiratory flow increased from 1.09 (0.41) L/seconds before surgery to 2.85 (0.67) L/seconds in long‐term.ConclusionPlastic cordotomy is an effective, anatomically based method to alleviate obstruction in bilateral vocal fold immobility patients. The main advantage of plastic cordotomy is long‐term stability of results due to prevention of restenosis. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Epidemiology of sebaceous carcinoma of the head and neck: Implications for lymph node management
Authors: Tryggvason Geir , Bayon Rodrigo , Pagedar Nitin A. 
Published: January 2012

AbstractBackgroundThe purpose of this study was to describe the incidence of nodal disease in sebaceous carcinoma and its impact on survival.MethodsData from the 17 registries of the Surveillance, Epidemiology, and End Results (SEER) database was retrospectively collected for sebaceous carcinoma from 1973 to 2007. Information on location, histologic grade, stage of disease, and survival was gathered.ResultsOne thousand eight hundred thirty‐six sebaceous carcinomas were diagnosed during the time period: 633 (34.5%) in the eyelid and 786 (42.8%) in the extraocular head and neck skin. Eyelid sebaceous carcinomas had higher histologic grade compared with tumors in extraocular sites (p < .001). Ocular sebaceous carcinomas had a higher incidence of regional or distant metastases at presentation (4.4%) compared with extraocular head and neck sites (0.9%; p = .03). There was a high incidence of N+ disease in poorly differentiated ocular sebaceous carcinomas (15.2%).ConclusionThe incidence of nodal disease was higher with eyelid tumors. Sentinel lymph node biopsy can be considered for eyelid tumors, but not for non‐eyelid head and neck tumors. © 2012 Wiley Periodicals, Inc. Head Neck, 2012
Outcomes of combined oncologic resection and carotid endarterectomy in patients with head and neck cancer
Authors: Kroeker Teresa R. , O'Brien John C. 
Published: January 2012

AbstractBackgroundPatients with head and neck cancer have similar risk factors to patients with carotid disease. Patients with head and neck cancer should be screened with vascular consultations obtained as indicated. Identification of significant carotid artery disease before surgical treatment of head and neck cancer is important in order to prevent perioperative and future strokes.MethodsEleven patients underwent carotid duplex ultrasound followed by vascular consultation for significant asymptomatic and symptomatic carotid stenosis. Carotid endarterectomy was performed during an oncologic resection of head and neck cancer between the years of 1996 and 2011.ResultsThere were no local or regional recurrences. There were no perioperative deaths or strokes. Two‐year and 5‐year survival were 70% and 29%, respectively, with a median survival of 51 months.ConclusionCollaboration of head and neck surgeons with vascular surgeons provides the patient with an oncologic resection and revascularization with a low perioperative risk of stroke. This improves the patient's quality of life by lessening the possibility of a stroke postoperatively. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
Selective facilitation of LTP in the ventral hippocampus by calcium stores
Authors: Grigoryan Gayane , Korkotian Eduard , Segal Menahem 
Published: January 2012

AbstractThe effects of low concentrations of caffeine and ryanodine on field excitatory postsynaptic potentials (EPSPs) and long‐term potentiation (LTP) were studied in CA1 region of slices of dorsal and ventral hippocampus (DH and VH, respectively). There was a striking difference between the two regions in the magnitude of effect of both drugs, as well as the ability to interact with a tetanic stimulation to produce LTP. Low concentration of caffeine (1 mM) produced a postsynaptic increase in the slope of population EPSPs in VH, and facilitated LTP in this region. Low concentration of ryanodine (0.2 μM) was able to convert short‐term potentiation (STP) to LTP in VH only. These effects are postsynaptic and they reflect a higher concentration of ryanodine receptors (RyRs) in the VH compared to the DH. © 2012 Wiley Periodicals, Inc.
Tumour burden predicts treatment resistance in patients with early unfavourable or advanced stage Hodgkin lymphoma treated with ABVD and radiotherapy
Authors: Gobbi Paolo G , Bassi Emilio , Bergonzi Manuela , Merli Francesco , Coriani Chiara , Iannitto Emilio , Luminari Stefano , Polimeno Giuseppe , Federico Massimo 
Published: January 2012

AbstractThe purpose of the work was to investigate the factors predicting early resistance to treatment in Hodgkin lymphoma. Many staging parameters, including relative tumour burden (rTB), were analysed in 246 patients with Hodgkin lymphoma in relation to early failure, that is, less than complete remission (i.e. partial response, null response or progression) or occurrence of early relapse, as clinical expressions of resistance to treatment. Patients with early unfavourable disease were 129 and were treated with four to six cycles of ABVD + involved field radiotherapy; 117 patients with advanced stage disease received six cycles of ABVD + optional irradiation to no more than two sites. The rTB was volumetrically measured through the evaluation of staging computed tomography for all the lesions except bone marrow involvement, which was quantified by calculation. The relationship with early resistance was analysed with logistic regressions. The rTB demonstrated to be the best predictor of early failure in both patient subsets, being superior to the multiparameter International Prognostic Score. The rTB showed a significant exponential relationship with the relative risk of early failure, and with inclusion of the extranodal involvement into the model, a single equation became adequate to predict resistance in both early unfavourable and advanced stage patients. The conclusions are that the rTB is the best pretreatment factor related to the risk of resistance to combined ABVD + radiotherapy and that this relationship can be mathematically expressed in an easy way. A simplified assessment of rTB is highly desirable. Copyright © 2012 John Wiley & Sons, Ltd.
Self‐reported history of infections and the risk of non‐Hodgkin lymphoma: An InterLymph pooled analysis
Authors: Becker Nikolaus , Falster Michael O. , Vajdic Claire M. , de Sanjose Silvia , Martínez‐Maza Otoniel , Bracci Paige M. , Melbye Mads , Smedby Karin Ekström , Engels Eric A. , Turner Jennifer , Vineis Paolo , Costantini Adele Seniori , Holly Elizabeth A. , Spinelli John J. , Vecchia Carlo La , Zheng Tongzhang , Chiu Brian C.‐H. , Montella Maurizio , Cocco Pierluigi , Maynadié Marc , Foretova Lenka , Staines Anthony , Brennan Paul , Davis Scott , Severson Richard , Cerhan James R. , Breen Elizabeth C. , Birmann Brenda , Cozen Wendy , Grulich Andrew E. , Newton Robert 
Published: January 2012

AbstractWe performed a pooled analysis of data on self‐reported history of infections in relation to the risk of non‐Hodgkin lymphoma (NHL) from 17 case–control studies that included 12,585 cases and 15,416 controls aged 16–96 years at recruitment. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were estimated in two‐stage random‐effect or joint fixed‐effect models, adjusting for age, sex and study centre. Data from the 2 years before diagnosis (or date of interview for controls) were excluded. A self‐reported history of infectious mononucleosis was associated with an excess risk of NHL (OR = 1.26, 95% CI = 1.01–1.57 based on data from 16 studies); study‐specific results indicate significant (I2 = 51%, p = 0.01) heterogeneity. A self‐reported history of measles or whooping cough was associated with an approximate 15% reduction in risk. History of other infection was not associated with NHL. We find little clear evidence of an association between NHL risk and infection although the limitations of data based on self‐reported medical history (particularly of childhood illness reported by older people) are well recognized.
Childhood maltreatment and prospectively observed quality of early care as predictors of antisocial personality disorder features
Authors: Shi Zhenyu , Bureau Jean‐Francois , Easterbrooks M. Ann , Zhao Xudong , Lyons‐Ruth Karlen 
Published: January 2012

AbstractFew studies have evaluated the separate contributions of maltreatment and ongoing quality of parent–child interaction to the etiology of antisocial personality features using a prospective longitudinal design. One hundred twenty low‐income young adults (aged 18–23) were assessed for extent of antisocial personality disorder (ASPD) features on the Structured Clinical Interview for Diagnosis (M.B. First, R.L. Spitzer, M. Gibbon, & J.B.W. Williams, 1997) for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (American Psychiatric Association, 1994) Axis II, for presence of maltreatment on the Conflict Tactics Scale (M.A. Straus, S.L. Hamby, D. Finkelhor, D.W. Moore, & D. Runyan, 1998), Traumatic Experiences Scale (L. Dutra, J.F. Bureau, B. Holmes, A. Lyubchik, & K. Lyons‐Ruth, 2009), and Adult Attachment Interview (C. George, N. Kaplan, & M. Main, 1984), and for referral in infancy to parent–infant clinical services. Fifty‐six of these families had been studied longitudinally since the first year of life. In infancy, attachment disorganization and disrupted mother–infant interaction were assessed; in middle childhood, disorganized‐controlling attachment behaviors were reliably rated. In kindergarten and second grade, behavior problems were assessed by teacher report. In cross‐sectional analyses, maltreatment was significantly associated with ASPD features, but did not account for the independent effect of early referral to parent–infant services on ASPD features. In longitudinal analyses, maternal withdrawal in infancy predicted the extent of ASPD features 20 years later, independently of childhood abuse. In middle childhood, disorganized attachment behavior and maladaptive behavior at school added to prediction of later ASPD features. Antisocial features in young adulthood have precursors in the minute‐to‐minute process of parent–child interaction beginning in infancy.
Compliance, opposition, and behavior problems in toddlers born preterm or low birthweight
Authors: Poehlmann Julie , Miller Schwichtenberg AJ , Hahn Emily , Miller Kyle , Dilworth‐Bart Janean , Kaplan David , Maleck Sarah 
Published: January 2012

AbstractAlthough children born preterm or low birth weight (PT LBW) are more likely to exhibit behavior problems compared to children born at term, developmental and family processes associated with these problems are unclear. We examined trajectories of maternal depressive symptoms in relation to toddler compliance and behavior problems in families with PT LBW infants. A total of 177 infants (93 boys, 84 girls) and their mothers enrolled in the study during the infant's NICU stay. Data were collected at five time points across 2 years. Assessments of maternal depressive symptoms were conducted at all time points, and toddler compliance and opposition to maternal requests and behavior problems were assessed at 2 years. Toddlers born earlier with more health problems to mothers whose depressive symptoms increased over time exhibited the most opposition to maternal requests during a cleanup task at 24 months, consistent with multiple risk models. Mothers with elevated depression symptoms reported more behavior problems in their toddlers. The study has implications for family‐based early intervention programs seeking to identify PT LBW infants at highest risk for problem behaviors.
Behavior problems in young children from low‐income families: The development of a new screening tool
Authors: Holtz Casey A. , Fox Robert A. 
Published: January 2012

AbstractThe purpose of this study was to construct a screening tool, the Early Childhood Behavior Screen (ECBS), to identify behavior problems and prosocial behaviors in very young children (1–5 years old) from low‐income backgrounds. Field testing of the initial screening tool was conducted with a representative, diverse sample of 439 parents from a low‐income, urban community. The final 20‐item scale was written at a 3.9 grade reading level. Psychometric properties of the ECBS revealed that the items loaded on two factors, the Challenging Behavior factor and the Prosocial Behavior factor. Each factor demonstrated high levels of internal consistency (.87 and .92, respectively). The Challenging Behavior factor demonstrated adequate levels of concurrent validity (r = .75), sensitivity (r = .82), and specificity (r = .80) based on its relationship with the Eyberg Child Behavior Inventory (S.M. Eyberg & D. Pincus, 1999). The Prosocial Behavior factor is a clinically useful aspect of the ECBS, as it allows researchers and practitioners to identify the child's positive behaviors as part of a strength‐based approach to treatment. The results suggested that the ECBS has potential as a brief screening tool that is useful in pediatric, psychological, and educational settings that serve low‐income populations to aid in the identification of young children with challenging behaviors that may require intervention services
Substance‐abusing mothers in residential treatment with their babies: Importance of pre‐ and postnatal maternal reflective functioning
Authors: Pajulo Marjukka , Pyykkönen Nina , Kalland Mirjam , Sinkkonen Jari , Helenius Hans , Punamäki Raija‐Leena , Suchman Nancy 
Published: January 2012

AbstractA residential treatment program has been developed specifically for substance‐abusing pregnant and parenting women in Finland, focusing on simultaneously supporting maternal abstinence from substances and the mother–baby relationship. The aims of the study are to explore maternal pre‐ and postnatal reflective functioning and its association with background factors, maternal exposure to trauma, and psychiatric symptoms, postnatal interaction, child development, and later child foster care placement. Participants were 34 mother–baby pairs living in three residential program units during the pre‐ to postnatal period. We employed self‐report questionnaires on background, trauma history, and psychiatric symptoms (Brief Symptom Inventory: L.R. Derogatis, 1993; Edinburgh Postnatal Depression Scale: J.L. Cox, J.M. Holden, & R. Sagovsky, 1987; Traumatic Antecedents Questionnaire: B. Van der Kolk, 2003), videotaped mother–child interactions coded for sensitivity, control, and unresponsiveness (Care Index for Infants and Toddlers: P. Crittenden, 2003); a standardized test of child development (Bayley Scales of Infant Development‐II: N. Bayley, 1993); and semistructured interviews for maternal reflective functioning (Pregnancy Interview: A. Slade, E. Bernbach, J. Grienenberger, D.W. Levy, & A. Locker, 2002; Parent Development Interview: A. Slade et al., 2005). Pre‐ and postnatal maternal reflective functioning (RF) was on average low, but varied considerably across participants. Average RF increased significantly during the intervention. Increase in RF level was found to be associated with type of abused substance and maternal trauma history. Mothers who showed lower postnatal RF levels relapsed to substance use more often after completing a residential treatment period, and their children were more likely to be placed in foster care. The intensive focus on maternal RF is an important direction in the development of efficacious treatment for this very high risk population.
Nanomolar melatonin enhances nNOS expression and controls HaCaT‐cells bioenergetics
Authors: Arese Marzia , Magnifico Maria Chiara , Mastronicola Daniela , Altieri Fabio , Grillo Caterina , Blanck Thomas J. J. , Sarti Paolo 
Published: January 2012

AbstractA novel role of melatonin was unveiled, using immortalized human keratinocyte cells (HaCaT) as a model system. Within a time window compatible with its circadian rhythm, melatonin at nanomolar concentration raised both the expression level of the neuronal nitric oxide synthase mRNA and the nitric oxide oxidation products, nitrite and nitrate. On the same time scale, a depression of the mitochondrial membrane potential was detected together with a decrease of the oxidative phosphorylation efficiency, compensated by glycolysis as testified by an increased production of lactate. The melatonin concentration, ∼ nmolar, inducing the bioenergetic effects and their time dependence, both suggest that the observed nitric oxide‐induced mitochondrial changes might play a role in the metabolic pathways characterizing the circadian melatonin chemistry. © 2012 IUBMB IUBMB Life, 2012
STAT3 interacts directly with Hsp90
Authors: Prinsloo Earl , Kramer Adam H. , Edkins Adrienne L. , Blatch Gregory L. 
Published: January 2012

AbstractHeat shock protein 90 (Hsp90) functionally modulates signal transduction. The signal transducer and activator of transcription 3 (STAT3) mediates interleukin‐6 family cytokine signaling. Aberrant activation and mutation of STAT3 is associated with oncogenesis and immune disorders, respectively. Hsp90 and STAT3 have previously been shown to colocalize and coimmunoprecipitate in common complexes. Surface plasmon resonance spectroscopy revealed a direct, high affinity specific interaction between recombinant Hsp90β and STAT3β in the presence and absence of adenosine triphosphate (ATP) in molar excess. Furthermore, comparative analysis using a phosphomimetic mutation at tyrosine 705 showed that the direct interaction appeared to favor neither unactivated nor activated STAT3. Destabilizing mutation of STAT3 at arginine residues 414/417 to alanine in the DNA‐binding domain, previously shown to disrupt nuclear translocation in vivo, reduced interaction with a STAT3 DNA binding site oligonucleotide and Hsp90β in vitro, indicating that STAT3 requires a functional DNA‐binding domain for full direct interaction with Hsp90. Site‐directed mutagenesis of a mammalian STAT3–EGFP‐N1 fusion construct at RR414/417 and subsequent transfection into human MCF7 epithelial breast cancer cells showed no impaired nuclear translocation when observed by confocal laser scanning microscopy. However, costaining for Hsp90α/β isoforms and colocalization analysis revealed a defined decrease in pixel‐on‐pixel colocalization compared with the wild‐type confirming the requirement of the DNA‐binding domain for high‐affinity interaction. © 2012 IUBMB IUBMB Life, 2012
Lead inhibits paraoxonase 2 but not paraoxonase 1 activity in human hepatoma HepG2 cells
Authors: Sukketsiri Wanida , Porntadavity Sureerut , Phivthong‐ngam Laddawal , Lawanprasert Somsong 
Published: January 2012

ABSTRACTLead is an environmental toxicant of great concern for humans and animals. Lead‐induced liver damage and malfunction are partly due to a disturbance of the cellular antioxidant balance. Paraoxonase 1 (PON1) and PON2 are highly expressed in the liver and have been proposed as antioxidative enzymes. In this study, the effects of lead on PON1 and PON2 activities were investigated in human hepatoma HepG2 cells by exposing the cells to various concentrations of lead acetate for 24, 48, or 72 h. The results show that a significant increase in reactive oxygen species was observed even at the lowest concentration of lead treatment. However, only the highest concentration of lead significantly influenced cell viability. Lead had no influence on cell‐associated PON1 activity, but it significantly decreased cytoplasmic PON2 activity in a concentration‐ and time‐dependent manner. This reduction was rescued by the addition of calcium. A significant increase of PON2 transcript was observed by real‐time polymerase chain reaction, while PON2 protein expression did not change in the western blot analysis. Taken together, these results indicate that lead reduces PON2, but not PON1, activity and that this reduction is reversed by calcium. Lead‐induced oxidative stress and decreased PON2 activity lead to the upregulation of PON2 transcript. Copyright © 2012 John Wiley & Sons, Ltd.