bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions through modulating the homeostasis of protein-membrane association
Authors: Yao Jinyi , Fu Zhenli , Li Keying , Zheng Jingjing , Chen Zicong , Xu Jiahao , Lai Guoqing , Huang Yaomin , Huang Jinsheng , You Guanying , Han Shuangxue , He Zhijun , Liu Qiong , Li Nan 
Published: June 2024

SummaryThe neurofilaments formed by hyperphosphorylated tau is a hallmark of tau-related neurodegenerative disease, including Alzheimer’s disease, tau related FTDP-17, Pick’s disease, et al. However, the biological functions of tau and the physiological significance of its phosphorylation are still not fully understood. By using human tau (441 a.a.) transgenic (hTau) mice in which murine tau has been deleted simultaneously, murine tau knockout (Tau KO) mice and C57BL/6J (C57) mice, unexpectedly, we found that under acute hyperglycemia conditions, JNK but not previously reported GSK-3β mediated tau phosphorylation. Moreover, Akt, the upstream GSK-3β inhibitory kinase, was activated in a tau dependent manner. By comparing the membrane-associated proteome, we found that human tau influenced the homeostasis of protein-membrane association under acute hyperglycemia conditions. Of note, with respect to WT and Tau KO mice, the membrane-association of Krts, TFAM, TRAP1, mTOR et al, were strengthened by human tau. Whereas, the membrane-association of ribosomal proteins Rpls, proteasome proteins Psmds, and mitochondrial proteins, such as COXs, Ndufa1, Mtnt4, et al, were impeded by human tau. In vitro study showed that aerobic glycolysis was promoted in the presence of human tau, which maintained NAD+/NADH ratio. On the other hand, it restricted oxidative phosphorylation level, modulated the activity of SDH, and reduced ROS production upon challenging by high glucose. Furthermore, under acute high glucose conditions, the presence of human tau significantly augmented Akt activation, but inhibited 4EBP phosphorylation simultaneously, indicating that human tau is also involved in regulating the alternative activation of mTORC1/2. In summary, the current study revealed that human tau played an important role in regulating glycolytic metabolism under acute high hyperglycemia conditions, which is similar with the Warburg-effect, through influencing the homeostasis of protein-membrane association.
3D small-gain formula allowing strong focusing and harmonic lasing for a ring-based x-ray free electron laser oscillator
Authors: Yu Li Hua , Smaluk Victor , Shaftan Timur , Tiwari Ganesh , Yang Xi 
Published: June 2024

We present a detailed derivation of a formula for the small-gain calculation for an x-ray free electron laser oscillator (XFELO) based on a medium-energy (3–4 GeV) storage ring. We found harmonic lasing and strong focusing are essential for this beam energy range. Taking the small-signal low-gain formula developed by Kim and his colleagues, we modified it in such a way that the gain can be calculated without the “no focusing approximation,” and a strong focusing can be applied, as well as harmonic lasing. In this formula, the gain is represented as a product of two factors with one of them depending only on the harmonic number, undulator period, and gap. Using this factor, we show that it is favorable to use harmonic lasing to achieve hard x-ray FEL working in the small-signal low-gain regime with the medium-energy electron beam. Our formula also allows FEL optimization by varying the vertical gradient of the undulator, the vertical dispersion, and the horizontal and vertical focusing, independently. As an example, we applied this formula to study the feasibility of an XFELO option for the National Synchrotron Light Source II (NSLS-II) upgrade. Since a quite high peak current is required for the FEL, collective effects of beam dynamics in medium-energy synchrotrons significantly affect the electron beam parameters. We carried out a multiparameter optimization taking collective effects into account. Note, even though our example is for a ring-based XFELO at 3 to 4 GeV, the formula and, in particular, the approach developed here may be applied to other types of FELs.

Published by the American Physical Society
2024
Toward a conceptual framework characterizing the interplay of interest development, information search, and knowledge construction (ISK) in Children’s learning
Authors: Jung Yong Ju , Liu Jiqun 
Published: June 2024

PurposeThis conceptual paper aims to demonstrate a holistic, multifaceted framework of interest development, information search, and knowledge construction (ISK) on children’s diverse information search behaviors.Design/methodology/approachBy reviewing previous literature on children’s interest development, online information seeking and search, and knowledge construction, we propose the ISK framework. Then, we provide example case studies with pilot analyses using qualitative approaches (e.g. video-based interaction analysis, thematic analysis) showing how the framework can be applied to different types of authentic information-seeking situations for children.FindingsThe ISK framework demonstrates the multifaceted interplays between children’s information behavior and their cognitive and affective development. This framework was supported using previous studies and pilot empirical applications. We also included potential research questions that could be addressed using the framework.Originality/valueOur paper provides a conceptual grounding to an in-depth, multidimensional understanding of children’s information behavior, which have been limitedly addressed in previous studies. Considering that children begin to search from their early stage of development and their search behaviors are tightly associated with other developmental states, our paper highlights the importance of investigating children’s search and information seeking and provides theoretical and empirical implications.
Paths of knowledge sharing of core and periphery users in online health communities: social support perspective
Authors: Ye Binhua , Chen Chaoran , Zhang Jiantong 
Published: June 2024

PurposeWhat’s the flow path of knowledge sharing among members in online health community (OHC)? Exploration of this issue could shed light on mechanisms behind user knowledge sharing and interaction on OHC, but few studies have focused on it. This study is going to address this research gap and to provide richer support for subsequent knowledge management related research.Design/methodology/approachBased on the core-periphery effect, this study combines content analysis and social network analysis to portray the paths of different types of social support for core and periphery users from social support perspective.FindingsResults reveal that the core users follow a pattern of high-stage and low-stage users with distinct needs, while the path pattern of the edge user group mainly consists support from high-stage to low-stage users. Results show that there is apparent distinction between the paths of emotional and informational support between core and periphery users. For core users, emotional support flows from lower stage users to higher stage users, while informational support follows the opposite direction. For periphery users, the paths of emotional support and informational support are identical, with both flowing from higher stage users to lower stage users.Originality/valueThis study explores the flow paths of information support and emotional support for core and periphery users, and discovers the different patterns of these two types of users, providing theoretical guidance for platform administrators to manage users more efficiently and ensure the sustainable development of the platform.
The mediating role of career resilience on Gen Z’s emotional intelligence and career outcomes
Authors: Barhate Bhagyashree , Winton Bradley G , Maugh Funderburk Casey 
Published: June 2024

Purpose
This study aims to investigate the mediating effect of career resilience (CR) on Generation Z’s emotional intelligence (EI) and perceived career outcomes such as career satisfaction (CSAT), burnout and intention to leave a career. In its short organizational tenure, Gen Z has faced the adverse effects of global events affecting their views of career and, ultimately, CR.

Design/methodology/approach
A cross-sectional survey method was used to test the hypothesized relationship. A total sample of 160 respondents were assessed. Hypotheses in this study were tested by using Hayes’s (2018) PROCESS tool based on OLS regression and with a bootstrap method.

Findings
The most significant finding of this study concludes that although small, CR has a positive mediating indirect effect on Gen Z’s CSAT and burnout. However, contrary to past findings, we found a negative relationship between Gen Z’s EI and CR. Furthermore, although EI and CSAT have a positive relationship, CR and CSAT are negatively correlated. Meanwhile, Gen Z’s EI through CR positively affects Gen Z’s CSAT.

Research limitations/implications
The study has implications for how organizations can attract, retain and engage Gen Z.

Originality/value
Despite Gen Z being a part of the workforce for at least six years, limited empirical research on Gen Z has been published. Indeed, Gen Z’s workforce inexperience does not yield in-depth explanations of CR concepts; however, as we continue to learn more about Gen Z and their interactions with the work environment, the authors begin to get a peek into the future of the workforce.
A bibliometric analysis of global research on education in the Scopus database, 2013–2022
Authors: Maral Muammer 
Published: June 2024

Purpose
The purpose of this study is to provide a comprehensive analysis of scientific knowledge in educational research over the past decade. The analysis aims to identify contributions to the field of education and trends in the literature.

Design/methodology/approach
Bibliometric analysis was conducted on 117,870 publications from 335 education journals in the Scopus database between 2013 and 2022.

Findings
This study shows educational research has increased consistently over the past decade. The USA showed high productivity, while the Netherlands produced the most impactful publications. The USA, UK and Australia have the highest research collaboration. Country collaboration network is divided into two blocks, comprising Western and Eastern countries, with the USA and the UK acting as bridges between these country groups. The bibliographic coupling analysis revealed that educational research is categorized into 11 clusters. Recent educational research aims to address the challenges in education, adapt to the changing technological, economic and social landscape and capitalize on emerging opportunities.

Originality/value
This study analysed over 100 thousand publications to identify the latest trends in educational research and highlight current developments in the field.
Promoting equity and equality in student learning: principals as social justice leaders in Kuwaiti schools
Authors: Alajmi Munirah 
Published: June 2024

PurposeThis qualitative study aimed to explore school principals' perceptions of social justice in a centralized school setting in Kuwait, as well as the challenges they face when promoting equity and equality for students' learning in schools.Design/methodology/approachData were collected through in-depth interviews with 18 public school principals from Kuwait's six educational districts.FindingsThe results revealed that principals' experiences and unique perspectives shape their definitions of social justice within their schools. Some school principals see social justice as ensuring fairness and equal opportunities for every student regardless of their backgrounds. Others focus on creating an inclusive and supportive environment. The results also showed that limited resources, institutional barriers, limited autonomy, lack of training, and some ministerial laws are among the challenges that school principals face in promoting equity and equality.Research limitations/implicationsThe findings are informative to policymakers and other educational stakeholders. Practical suggestions are provided to improve school principals' social justice leadership practices.Originality/valueThis study adds to the empirical knowledge of school principals' role in promoting equity and equality for student learning in a centralized school setting and attempts to reduce the social justice leadership gap in schools.
Using a virtual patient system to improve medical students’ confidence in clinical diagnosis: a controlled study
Authors: Lee Yew Kong , Lee Ping Yein , Lau Yee Ling , Ng Chirk Jenn , Ng Wei Leik , Chiew Thiam Kian , Abdullah Adina , Vadivelu Jamuna , Amir Amirah , Tan Christina Phoay Lay , Chin Caroline Kwong Leng 
Published: June 2024

PurposeThis study aimed to evaluate the effectiveness of using a virtual patient (VP) software program in increasing clinical reasoning skills confidence among medical students.Design/methodology/approachA quasi-experimental design was used to compare the outcomes of students’ confidence levels on clinical reasoning between problem-based learning (PBL) and VP program with 122 pre-clinical Year 2 medical students. History taking, physical examination, clinical investigations and diagnosis was investigated using four PBL cases in the oncology block. Pre- and post-differences in mean confidence scores between the arms were compared, as well as mean difference by type of case and skill category.FindingsA total of 122/156 (78.2%) students participated; n = 55 were from 7 VP groups and n = 67 were from 13 control arm groups. For the primary outcome, the VP arm showed a statistically significant increase in confidence measures among 11/16 (4 cases × 4 skills) categories, compared to 4/16 for the control arm. The proportion of the students who indicated an improved confidence was statistically significant for the cervical cancer case for physical examination (60.0% improved in VP vs 12.5% in control), investigation (60.0% VP vs 18.8% control) and diagnosis (60.0% in VP vs 25.0% in control). Finally, analysis by case showed an increment in overall mean scores from the start to end of the case within the VP arm while the pattern was erratic in the control arm cases.Originality/valueThe study results showed that incorporating the VP into PBL was more effective in increasing students’ clinical reasoning confidence levels compared to the usual PBL. As the study utilized existing PBL cases, it demonstrates how medical schools can incorporate digital VP tools into pre-clinical years before students' transition to learning from actual patients in the clinical years.
Theoretical framework for carbon trading in the built environment
Authors: Kukah Augustine Senanu Komla , Jin Xiaohua , Osei-Kyei Robert , Perera Srinath 
Published: June 2024

Purpose
This conceptual paper aims to develop a theoretical framework for carbon trading in the built environment through theories to expand current knowledge on components of carbon trading systems.

Design/methodology/approach
This theoretical framework was developed and supported with existing theories and past empirical literature from built environment, economics and finance. Underlying theories used in the framework were selected due to their significance and applicability to carbon trading projects. Hypotheses set in the study summarise the propositions developed from the theories and past empirical literature.

Findings
The framework reveals four major components of carbon trading for the built environment. Six hypotheses were further proposed to unravel the resultant influence of their interactions on each component in the trading system.

Research limitations/implications
This paper sought to undertake a theoretical review of classical theories and past studies on carbon trading. Even though a systematic review was undertaken, the constructs in the theoretical framework may not be exhaustive.

Practical implications
This study contributes and advances the body of knowledge on the components that comprise the mechanism of how carbon trading operates in the built environment. Theoretically, the framework developed serves as a multi-dimensional guide on the operations of carbon trading in the built environment.

Originality/value
The theoretical framework developed endeavours to consolidate multi-faceted theories from varying disciplines on the components that comprise carbon trading in the built environment.
Determinants of purchase intention towards halalcertified cosmetic products among nonMuslims
Authors: Ibeabuchi Chukwuebuka , Ehido Amauche , Fawehinmi Olawole , Aigbogun Osaro 
Published: June 2024

Purpose
There is paucity of research on the significant criteria that non-Muslims consider when purchasing halal cosmetics. Consequently, this paper aims to apply the theory of planned behaviour (TPB) and the health belief model (HBM) to investigate the effects of subjective norms (SN), perceived behavioural control (PBC), halal certification and health consciousness on attitude; as well as the impact of attitude on promoting the intention to purchase halal cosmetic products among non-Muslims.

Design/methodology/approach
Data collection involved the use of a web-based survey of 238 non-Muslim respondents that are resident in Malaysia, a south east Asian country reputed for being the global hub for halal products. The proposed model was evaluated using Smart PLS 3.3.5.

Findings
According to the structural model results, halal certification, health consciousness and SN have significant relationships with attitude. In addition, there are significant relationships between attitude, health consciousness, SN and the intention to purchase halal cosmetic products. In contrast, there is no correlation between halal certification, PBC and intention to purchase halal cosmetics. Furthermore, attitude significantly mediates the relationships between halal certification, SN, health consciousness and intention to purchase halal cosmetics. However, attitude did not significantly fulfil the role of a mediator in the relationship between PBC and intention to purchase halal cosmetic products.

Originality/value
The study findings provide valuable insights to companies targeting non-Muslim markets. The study findings contend how halal cosmetic production/marketing companies may customize their marketing activities based on social and health perspectives, thereby increasing the consumers’ social expectations and confidence in halal cosmetics production standards and guaranteeing safety to influence their attitudes and quickly penetrate the new market for non-Muslim consumers who make a relatively unexplored population.
Modeling of barriers to digital transformations in Indian manufacturing small and medium-sized enterprises
Authors: Borana Nikita , Gaur Tejendra Singh , Yadav Vinod 
Published: June 2024

Purpose
In recent times, digital transformation (DT) has witnessed a surge in popularity, not only within large enterprises (LEs) but also among small and medium-sized enterprises (SMEs). Various sectors, including manufacturing, have shown a keen interest in embracing DT for their operational and supply chain needs. Beyond delivering benefits such as improved product quality, revenue growth, enhanced customer service and heightened safety measures, DT offers a range of advantages, including heightened productivity, risk mitigation and environmental protection. However, in developing countries like India, manufacturing SMEs encounter significant challenges when attempting to embrace DT. Therefore, this study aims to identify and model the obstacles that impede DT adoption within the context of Indian manufacturing SMEs.

Design/methodology/approach
The literature review was used to pinpoint the barriers to adopting DT. Subsequently, these identified barriers underwent validation within the specific context of Indian manufacturing SMEs through the assessment of an expert team. The expert team proceeded to model these barriers using the interpretive structural modeling approach.

Findings
This study shows that high investment, return on investment and multiskilled workforces are the most crucial barriers to DT adoption. The proposed study aids policy and decision-makers in identifying the connections and dependencies between the barriers.

Originality/value
It provides a guideline for practitioners to deal with DT adoption barriers in the Indian manufacturing SMEs.
Outsourcing or in-housing: remanufactured product warranty of independent remanufacturer
Authors: Meng Lijun , Xue Jingya , Zhang Baoyou , Xia Hongying 
Published: June 2024

PurposeThis study attempts to determine the optimal pricing and warranty strategies for remanufactured products offered by independent remanufacturers (IRs). Specifically, it takes into account price competition and warranty service competition between the original equipment manufacturer (OEM) and IR, ultimately providing recommendations on the selection of warranty service modes for IRs.Design/methodology/approachThis study considers two warranty modes for IRs: in-housing and outsourcing. Based on game theory, this study identifies the conditions under which the warranty service for remanufactured product is outsourced to retailers in IR-remanufacturing mode. Furthermore, this study investigates how this strategic decision affects closed-loop supply chain (CLSC) operations by comparing the two modes in terms of profit, consumer surplus (CS), quantity and overall social welfare (SW).FindingsFirstly, the provision strategy for IRs' warranty on remanufactured products depends mainly on the retailer’s warranty cost. If retailers have lower costs for warranties, IR opts to outsource the remanufactured product warranty to the retailer. Second, when retailers offer warranties at a lower cost, IRs prefer outsourcing remanufactured product warranty to retailers. In this way, it will maximize both the remanufacturer’s and retailer’s profits while achieving the optimal total profit for the entire supply chain. However, it’s not beneficial for the OEM. Third, the IR’s preference for warranty service provision strategy is influenced by customers’ acceptance of remanufactured product, customer sensitivity toward remanufactured product warranty and economies of scale in warranty service.Practical implicationsThe findings offer operational insights into IR decision-making in selecting warranty service provision strategies for remanufactured products.Originality/valueThis study is among the first to examine warranty provision strategy for IRs in CLSC.