bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salt repletion and diuretic response: The role of serum chloride. A post‐hoc analysis of the SALT‐HF trial on furosemide and hypertonic saline solution administration in ambulatory patients with worsening heart failure
Authors: Núñez Julio , Miñana Gema , de la Espriella Rafael , Zegrí‐Reiriz Isabel , Comín‐Colet Josep , Rubio Gracia Jorge , Morales‐Rull Jose Luis , Llàcer Pau , Diez‐Villanueva Pablo , de Juan Bagudá Javier , Ortiz Cortés Carolina , Goirigolzarri‐Artaza Josebe , García‐Pinilla Jose Manuel , Barrios Elvira , del Prado Díaz Susana , Jiménez‐Marrero Santiago , Restrepo‐Córdoba Maria Alejandra , Testani Jeffrey , Cobo Marcos Marta 
Published: February 2025

ABSTRACTAimsThe efficacy of combining hypertonic saline solution (HSS) with loop diuretics in worsening heart failure (WHF) remains uncertain. Hypochloraemia has been associated with reduced diuretic efficacy. Some authors propose that chloride repletion may enhance natriuretic and diuretic responses. This post‐hoc analysis of the SALT‐HF trial evaluated the effect of single‐dose administration of HSS plus intravenous (IV) furosemide versus IV furosemide, stratified by baseline serum chloride.Methods and resultsThe analysis included 148 ambulatory patients with WHF from the double‐blind, randomized SALT‐HF trial. Participants received either an IV single dose of HSS plus furosemide or IV furosemide. The endpoints were 3‐h urinary sodium excretion and diuresis, 7‐day congestion score, and 30‐day adverse events according to chloride levels. Multivariable linear and logistic regression models assessed the relationship between the intervention and the endpoints. The mean baseline serum chloride level was 100 ± 4 mmol/L. Sixteen patients (10.8%) were identified as hypochloraemic (serum chloride <96 mmol/L), balanced between treatment groups. Patients with hypochloraemia showed a lower natriuretic response (p < 0.05). Interaction analysis revealed a between‐treatment differential natriuretic effect based on the chloride levels (pinteraction = 0.008). HSS plus furosemide increased natriuresis compared to furosemide at lower chloride levels. No differential between‐treatment effect was found for 3‐h diuresis. Similar heterogeneous results were found for the 7‐day clinical congestion score and 30‐day heart failure events, with a benefit with HSS in patients with lower chloride levels.ConclusionIn ambulatory patients with WHF and hypochloraemia, adding HSS to furosemide may improve short‐term natriuretic response and outcomes. These findings suggest that chloride supplementation may help overcome diuretic resistance in these patients.
Journey toward affordable and modern energy: Role of income inequality and technological innovation
Authors: Adebayo Tomiwa Sunday , Olanrewaju Victoria Olushola 
Published: February 2025

AbstractPromoting the shift toward clean and sustainable energy sources has been a key policy priority for the United Kingdom, as it is recognized as a critical pathway towards achieving carbon neutrality targets. Based on this, the study explored the impact of technological innovations, financial development, and income inequality on renewable energy consumption using data from 1980Q1 to 2021Q4. Taking into account the nonlinear and non‐normal distribution of the variables, the study employed wavelet‐based quantile techniques. Specifically, wavelet quantile ADF and PP tests were utilized to examine the stationarity properties of the data across different time horizons and quantiles. Additionally, wavelet quantile‐on‐quantile regression was used which focuses on various time horizons and quantiles. As a robustness check, wavelet quantile regression and average wavelet quantile‐on‐quantile regression were applied. The results revealed that across all time‐scales (short, medium and long‐term) and quantiles (0.1–0.90), economic growth, income inequality, and financial development positively influence renewable energy consumption. In addition, technological innovations were found to have mixed effect on renewable energy consumption. The study proposed policies based on these findings.
Profiling Precursor microRNAs of Breast Cancer From Total RNA Sequencing Data to Gain Insights Into Their Roles and Prognostic Values
Authors: Wu Sen , Pan Jia‐Wern , Citartan Marimuthu , Tang Thean‐Hock ,   MyBrCa Collaborative Group, Teo Soo‐Hwang , Ch'ng Ewe Seng 
Published: February 2025

ABSTRACTBreast cancer, a molecularly heterogeneous disease, is classified into hormone receptor‐positive luminal breast cancer (LBC), human epidermal growth factor receptor 2‐positive breast cancer, and triple‐negative breast cancer (TNBC). Precursor microRNAs (pre‐miRNAs), typically form hairpin structures with a length from 65 to 80 bases, are shown to play crucial roles in breast cancer carcinogenesis. We hypothesized that these pre‐miRNAs could have been sequenced in total RNA sequencing (RNA‐seq) and developed a novel algorithm to profile pre‐miRNAs from raw total RNA‐seq data. A total of 907 breast cancer samples curated by Malaysian Breast Cancer Genetic Study (MyBrCa) were profiled using this algorithm and a comparison was made between pre‐miRNA profiles and mature miRNA profiles obtained from The Cancer Genome Atlas (TCGA) dataset. We explored differentially expressed pre‐miRNAs in TNBC in comparison to LBC and conducted downstream functional analyses of the target genes. A prognostic signature was built by LASSO–Cox regression on selected pre‐miRNAs and validated internally and externally by MyBrCa and TCGA datasets, respectively. As a result, 10 common differentially expressed pre‐miRNAs were identified. Functional analyses of these pre‐miRNAs captured certain aggressive TNBC behaviors. Importantly, a pre‐miRNA signature composed of 4 out of these 10 pre‐miRNAs significantly prognosticated the breast cancer patients in the MyBrCa cohort and TCGA cohort, independent of conventional prognostic factors. In conclusion, this novel algorithm allows profiling pre‐miRNAs from raw total RNA‐seq data, which could be cross‐validated with mature miRNA profiles for cross‐platform comparison. The findings of this study underscore the importance of pre‐miRNAs in breast cancer carcinogenesis and as prognostic factors.
Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross‐Sectional Datasets Across the Lifespan
Authors: Schilling Kurt G. , Ramadass Karthik , Sairanen Viljami , Kim Michael E. , Rheault Francois , Newlin Nancy , Nguyen Tin , Barquero Laura , D'archangel Micah , Gao Chenyu , Topolnjak Ema , Khairi Nazirah Mohd , Archer Derek , Beason‐Held Lori L. , Resnick Susan M. , Hohman Timothy , Cutting Laurie , Schneider Julie , Barnes Lisa L. , Bennett David A. , Arfanakis Konstantinos , Vinci‐Booher Sophia , Albert Marilyn ,   The BIOCARD Study Team,   The Alzheimer's Disease Neuroimaging Initiative (ADNI),   Aging Brain: Vasculature, Ischemia, and Behavior (ABVIB), Moyer Daniel , Landman Bennett A. 
Published: February 2025

ABSTRACTHead motion during diffusion magnetic resonance imaging (MRI) scans can cause numerous artifacts and biases subsequent quantification. However, a thorough characterization of motion across multiple scans, cohorts, and consortiums has not been performed. To address this, we designed a study with three aims. First, we aimed to characterize subject motion across several large cohorts, utilizing 13 cohorts comprised of 16,995 imaging sessions (age 0.1–100 years, mean age = 63 years; 7220 females; 3175 cognitively impaired adults; 471 developmentally delayed children) to describe the magnitude and directions of subject movement. Second, we aimed to investigate whether state‐of‐the‐art diffusion preprocessing pipelines mitigate biases in quantitative measures of microstructure and connectivity by taking advantage of datasets with scan‐rescan acquisitions and ask whether there are detectable differences between the same subjects when scans and rescans have differing levels of motion. Third, we aimed to investigate whether there are structural connectivity differences between movers and non‐movers. We found that (1) subjects typically move 1–2 mm/min with most motion as translation in the anterior–posterior direction and rotation around the right–left axis; (2) Modern preprocessing pipelines can effectively mitigate motion to the point where biases are not detectable with current analysis techniques; and (3) There are no apparent differences in microstructure or macrostructural connections in participants who exhibit high motion versus those that exhibit low motion. Overall, characterizing motion magnitude and directions, as well as motion correlates, informs and improves motion mitigation strategies and image processing pipelines.
Treatments and Outcomes of Newly Diagnosed CD5‐Positive Diffuse Large B‐Cell Lymphoma: A Multi‐Institutional Observational Study
Authors: Nato Yuma , Miyazaki Kana , Maruyama Dai , Takahashi Hiroyuki , Sunami Kazutaka , Murakami Satsuki , Negoro Eiju , Miyazawa Yuri , Choi Ilseung , Okada Takahiro , Takayama Nobuyuki , Tomita Naoto , Momose Shuji , Kaneda Yuto , Yoshida Masahiro , Gomyo Hiroshi , Toyama Kohtaro , Nishikori Momoko , Saito Akio , Hiraga Junji , Masunari Taro , Takahashi Naoki , Makiyama Junya , Suzuki Tomotaka , Tsunemine Hiroko , Takizawa Jun , Kato Takeharu , Masaki Yasufumi , Fukuhara Noriko , Okamoto Masataka , Tawara Isao , Asano Naoko , Ohshima Koichi , Izutsu Koji , Kato Koji , Suzuki Ritsuro , Yamaguchi Motoko 
Published: February 2025

ABSTRACTCD5‐positive diffuse large B‐cell lymphoma (CD5+ DLBCL) is characterized by a poor prognosis and frequent central nervous system (CNS) relapse. Sandwich therapy comprising dose‐adjusted (DA)‐EPOCH‐R (etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin, and rituximab) and high‐dose methotrexate (HD‐MTX) (DA‐EPOCH‐R/HD‐MTX) showed excellent efficacy and manageable safety in a phase II study of patients diagnosed with stage II–IV CD5+ DLBCL. To validate the results of that study and elucidate the current state of treatment for CD5+ DLBCL, we retrospectively analyzed the outcomes of patients with CD5+ DLBCL diagnosed between 2016 and 2021 who received anthracycline‐containing chemotherapy with rituximab. Among the 346 patients evaluated, 62 (18%) received DA‐EPOCH‐R/HD‐MTX. The median follow‐up time was 43 months. In 55 patients with stage II–IV disease treated with DA‐EPOCH‐R/HD‐MTX, the 2‐year overall survival (OS), progression‐free survival, and cumulative incidence of CNS relapse were 87% (95% CI, 73%–94%), 76% (95% CI, 61%–86%), and 7.3% (95% CI, 2.4%–16%), respectively. There were no treatment‐related deaths. Febrile neutropenia occurred in 18 (33%) patients. Multivariate analysis of the 346 patients identified elevated serum lactate dehydrogenase levels, multiple extranodal involvement, no intrathecal MTX (IT‐MTX), and no DA‐EPOCH‐R/HD‐MTX as independent risk factors for OS. Only one CNS relapse event was observed in 28 patients who received both HD‐MTX and IT‐MTX. Our study provides real‐world data on the treatments and outcomes of a large number of patients. The favorable survival and manageable toxicity of DA‐EPOCH‐R/HD‐MTX have been validated in clinical settings. The use of HD‐MTX and IT‐MTX might be effective for preventing CNS relapse in patients with CD5+ DLBCL.
Remote Sensing‐Based Ecohydrogeological Characterisation and Perceptual Model of the Bale Mountains, Ethiopia
Authors: Chignell Stephen M. , Kim Yeonuk , Johnson Mark S. 
Published: February 2025

ABSTRACTThe Bale Mountains are a volcanic region in south‐central Ethiopia comprising Africa's largest alpine plateau and its adjacent montane forest. The region is recognised biologically as a centre of endemism, and hydrologically as a ‘water tower’, being the source of several rivers of critical importance for East Africa. However, little formal hydrologic data exist, and land management decisions are being made based largely on a mental model that assumes high vulnerability to changes in land use and land cover. We questioned this model using remote sensing data via Google Earth Engine to map spatial and temporal patterns of key hydrologic variables over the 20‐year period spanning 2001–2020. We combined a quantitative water balance analysis with qualitative interpretation of the region's geologic and geomorphic features. Our results show that, on average, annual evapotranspiration in the forested area exceeds annual precipitation. Evapotranspiration for the forest was seen to increase throughout the long dry season, exceeding its equilibrium value, suggesting that forest vegetation is neither water‐limited nor energy‐limited, and may be subsidised by groundwater and/or soil moisture flow derived from upslope areas and thermal vents. These results confound assumed relationships among forests, wetlands, and human activity embedded in much of the region's scientific research and conservation policies. We conclude by offering a new model and set of working hypotheses from which future scientific studies and management policies can benefit.
Information Flows, Stock Market Volatility and the Systemic Risk in Global Finance
Authors: Chen Yen‐Hsiao , Wu Jiang , McManus Richard , Liu Yang 
Published: February 2025

ABSTRACTInformation flows are a theoretical explanation for stock market volatility, but controversy remains regarding how to measure them. Based on cross‐sectional and temporal properties of information flows, we decompose total trading volume into four types: cross‐country shocks and country‐specific shocks due to arrivals of private information, and trading volume shocks and stock volatility shocks due to public information. We then use a Structural Vector Autoregressive model to reconstruct historical trading volume resulted from the four types of information shocks. The evidence shows that the historical trading volumes due to private information flow can explain volatility clustering of stock markets. By analysing sources of information flow, we find private information flow reflects systemic risk in the global financial system. The result conforms to Mixture of Distribution Hypothesis and finds that quality of information content is what differentiates privately informed trading from public information trading. It further suggests the main drivers of stock market volatility are uncertainties about fundamental values of assets and about other investors' behaviours.
Re‐Investigating Ireland's Maximum Air Temperature Record—Kilkenny Castle, 26 June 1887
Authors: Kelly Ciarán , O'Sullivan John , McGovern Jonathan , Curley Mary 
Published: February 2025

ABSTRACTIn this study, data rescue and analysis of available station archives from the late 19th and the early 20th century were carried out to re‐investigate Ireland's maximum air temperature record of 33.3°C at Kilkenny Castle on 26 June 1887. In addition to analysing this data in detail, we also conducted a comprehensive investigation of newspaper archives and meteorological documents published at the time of the record. The year 1887—and the month of June in particular—was exceptional in Ireland, with unprecedented drought and heat conditions across the island. Many places saw high temperatures during this period, with several stations recording temperatures in excess of 30°C. We also investigated inspectors' reports and station metadata for Kilkenny Castle, which lend support to the record temperature. A thorough analysis of the rescued data showed that for some measures (such as the temperature spread across the island on the day of the record), the data support the record temperature; but for some other measures (such as the monthly mean of maximum temperatures), the difference between Kilkenny and the neighbouring stations appears to be anomalous. Following a careful consideration of all of the evidence from both the metadata and the data analysis, our recommendation is that the long‐standing record maximum air temperature value of 33.3°C for Kilkenny Castle on 26 June 1887 should continue to stand, but with some reservations noted.
Accomplishing the SDGs Through Green HRM Practices: Insights From Industrial Sustainability Experts
Authors: Zaidi Syed Yasir Abbas , Aslam Muhammad Faisal , Mahmood Faisal , Ahmad Bilal , Tasaddque Sadia 
Published: February 2025

ABSTRACTIn the contemporary global context, the imperative to simultaneously address environmental, social, and economic challenges has become a paramount global goal. The corporate sector, identified as a significant contributor to environmental crises, is under immense pressure from diverse stakeholders, including regulators, activists, consumers, and competitors, who express concerns about the sector's unsustainable practices. In response to these challenges, the United Nations introduced sustainable development goals (SDGs) in 2015, envisioning a planet that thrives for all by 2030. Although the achievement of SDGs has become a global agenda, the role of green human resource management practices (GHRMPs) in this pursuit remains inadequately understood. This qualitative study seeks to address the overarching question of how GHRMPs contribute to the actualization of the environmental, economic, and social SDGs. Drawing insights from semi‐structured interviews and focus group discussions with 20 sustainability experts, thematic analysis revealed that specific sub‐practices within six core GHRMPs are intricately linked to distinct SDGs. For instance, inclusive hiring practices and diversity programs are identified to contribute to reducing inequalities (SDG 10). Gender‐inclusive groups provide a platform for employees to voice concerns and ideas, encouraging equal participation of men and women in decision‐making processes, ensuring diverse perspectives are considered (SDG 5). Designing healthier workplaces reduces the risk of occupational illnesses and injuries, supports a healthy lifestyle, and contributes to improved overall well‐being (SDG 7). This study offers valuable guidance to business policymakers and civil society actors aiming to enhance the scope of sustainable corporate practices.
The prevalence of constipation in children with new diagnosis of inflammatory bowel disease (IBD): A retrospective study
Authors: Sabrina Cenni , Antonio Colucci , Salomone Simona , Daniela Pacella , Marianna Casertano , Pietro Buono , Massimo Martinelli , Erasmo Miele , Annamaria Staiano , Caterina Strisciuglio 
Published: February 2025

AbstractObjectivesFunctional constipation (FC) is a common problem in childhood and the first‐line therapy is macrogol. The role of FC in the onset of inflammatory bowel disease (IBD) is poorly understood. Our main aim was to investigate the prevalence of FC in children before the diagnosis of IBD.MethodsThis is a cross‐sectional observational study in pediatric IBD‐patients. We collected data on demographics, clinical and endoscopic characteristics at IBD diagnosis, and on the presence of FC and its treatment before IBD diagnosis.ResultsA total of 238 children with IBD, 104 (44%) with Crohn disease (CD), 130 (56%) with ulcerative colitis (UC) and 4 (0.016%) with IBD Unclassified (IBD‐U) were enrolled. The mean age was 174 ± 47 months, 56% were male. Forty‐seven out of 238 (19.7%) had a FC history before the IBD diagnosis and 31 out of these 47 patients (65%) received macrogol therapy. In the FC group, we found a delay in the diagnosis of IBD compared to the group with no FC [median (interquartile range [IQR]): 5 months (2.5–9.5) and 2 months (0–4), respectively, p ≤ 0.001]. The difference in terms of endoscopic localization was statistically significant in UC patients presenting FC (p = 0.026) with a prevalence of proctitis and left side colitis (30% and 15%, respectively).ConclusionIn conclusion our study highlighted a prevalence of constipation in pediatric IBD patients at diagnosis of 19.7%, which must be taken into account to avoid diagnostic delay and which is associated with limited extent of disease in UC pediatric patients.
Development and psychometric validation of a clinical instrument for infant feeding and lifestyle evaluation
Authors: Chan Daniel , Lin Jiaying , Zheng Ruther Teo , Ong Chengsi , Ku Chee Wai , Loo Benny Kai Guo , Chan Jerry Kok Yen , Chua Mei Chien , Yap Fabian , Loy See Ling 
Published: February 2025

AbstractObjectiveThere is an absence of a comprehensive clinical instrument to assess and track the development of non‐ideal feeding practices and lifestyle behaviours in early childhood. Our primary aim was to develop and validate an assessment instrument, called Feeding, Lifestyle, Activity Goals (FLAGs), designed to serve as a feeding, lifestyle and activity behaviour checklist for children aged 0–2 years.MethodsThis study took place between January and May 2023. Experts evaluated content validity using the criteria of relevance, clarity, simplicity and ambiguity, to calculate the item content validity index (I‐CVI) and scale CVI (S‐CVI) (acceptable cutoff ≥ 0.80). Face validity was assessed by caregivers. Repeated assessments were also performed to determine test‐retest reliability based on intra‐class correlation (ICC) (acceptable cutoff > 0.75). Construct validity was established through principal component analysis (PCA), and internal consistency was measured using Cronbach's α coefficient (acceptable cutoff ≥ 0.70).ResultsFLAGs consists of 19 items, with a I‐CVI of 1.00 in 12 out of 19 items, and S‐CVI average of >0.90 for relevance, simplicity and clarity. Among 198 caregivers, 99.0% responded ‘agree’ and ‘strongly agree’ in the criteria of clarity and ambiguity; 99.5% in criterion of relevance, and 100% in criterion of simplicity. PCA showed a two‐component structure (55.9% variance). Overall Cronbach's α was 0.71. Participants repeated FLAGs assessment on an average of 9 days apart, with ICC of 0.861 (p < 0.001) for the total FLAGs scores.ConclusionsWe have developed an instrument which assesses an infant's feeding and lifestyle behaviour from 0 to 2 years, and this has been assessed to have acceptable validity and reliability.