bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions between soil, rainfall, and wildlife drive surface water quality across a savanna ecosystem
Authors: Strauch Ayron M. 
Published: January 2012

ABSTRACTSurface water resources play an important role in the transportation of nutrients within and between regions. Water quality varies spatially across landscapes, but the extent of this variability and the interaction between water quality and wildlife are not well‐known. In some savannas, heterogeneous climatic and geologic patterns result in gradients of precipitation and soil nutrients, leading to temporal and regional differences in soil and vegetation quality. Wildlife utilise these seasonal patterns, influencing soil nutrient dynamics and vegetation. However, the impact of seasonally abundant wildlife, climate, and soils on surface water quality is unknown in savannas. Fluctuations in surface water quality were measured across the Serengeti ecosystem at 6‐month intervals, and the influence of rainfall, watershed, and seasonal wildlife migration were then modelled. The results suggest that although soil composition in watersheds influences the concentration of soil‐derived nutrients in rivers, rainfall and wildlife have a significant effect on the seasonal concentrations of most nutrients. The role of migratory wildlife in surface water quality in some watersheds is likely dampened by the large influence of resident species across seasons and habitats. The alteration of rainfall patterns by climate change is expected to influence nutrient transport into savanna rivers. Copyright © 2012 John Wiley & Sons, Ltd.
Highly Enantioselective Synthesis of Spiro[cyclohexanone‐oxindoles] and Spiro[cyclohexanone‐pyrazolones] by Asymmetric Cascade [5+1] Double Michael Reactions
Authors: Wu Bin , Chen Jian , Li Mei‐Qiu , Zhang Jin‐Xin , Xu Xiao‐Ping , Ji Shun‐Jun , Wang Xing‐Wang 
Published: January 2012

AbstractThe asymmetric catalytic synthesis of naturally occurring and biologically active spiro compounds is a challenge for modern chemical methodology. Here we report the construction of spiro compounds through cascade [5+1] double Michael reactions between divinyl ketones and N‐unprotectedoxindoles or N‐phenyl‐protected pyrazolones catalyzed by a combination of the easily available 9‐amino‐9‐deoxy‐epi‐quinine with N‐Boc‐D‐phenylglycine. The desired multistereogenic spiro[cyclohexanone‐oxindoles and ‐pyrazolones] were obtained with high yields (up to 98 %) andstereoselectivities (up to >20:1 dr, 99 % ee).
Seeking good peer review in geomorphology
Authors: Lane Stuart N. 
Published: January 2012

ABSTRACTThis paper provides an extended guide to reviewing for ESPL in particular and geomorphology in general. After a brief consideration of both how we choose reviewers and why we hope that reviewers will accept, I consider what makes a fair and constructive review. I note that we aim to publish papers with the rigour (r) necessary to sustain an original and significant contribution (q). I note that judging q is increasingly difficult because of the ever‐growing size of the discipline (the Q). This is the sense in which we rarely have a full appreciation of Q, and our reviews are inevitably going to contain some bias. It is this bias that cannot be avoided (cf. Nicholas and Gordon, 2011) and makes the job of ESPL's Editors of critical importance. With this in mind, I identify six elements of a good review: (1) an introductory statement that explains your assessment of your competences in relation to the manuscript (r and Q); (2) a summative view of the originality and significance of the manuscript (q) in relation to Q: (3) a summative view of the methodological rigour of the manuscript (r); (4) identification and justification of any major concerns; (5) identification of any minor issues to be corrected if you think the manuscript merits eventual publication; and (6) note of any typographical or presentation issues to be addressed although this latter activity is also an editorial responsibility. In addition, I note the importance of a constructive review, grounded in what is written in the manuscript, justified where appropriate and avoiding reference to personal views as far as is possible. I conclude with a discussion of whether or not you should sign your review openly and the importance of reviewer confidentiality. Copyright © 2012 John Wiley & Sons, Ltd.
Asenapine: novel antipsychotic for treatment of bipolar I disorder
Authors: Bishara Delia , Whiskey Eromona , Taylor David 
Published: January 2012

AbstractAsenapine is a new antipsychotic agent with activity for multiple receptors. It is administered sublingually for the treatment of moderate to severe manic episodes associated with bipolar I disorder in adults. In this Drug profile the authors review the pharmacodynamic and pharmacokinetic properties of asenapine, and discuss its efficacy in bipolar I disorder and its likely positioning in clinical practice. Copyright © 2011 John Wiley & Sons, Ltd.
Lean Production—An Evaluation of the Possibilities for an Employee Supportive Lean Practice
Authors: Hasle Peter 
Published: January 2012

AbstractLean is a contested concept. It has been praised for empowering employees, and it has been criticized for intensifying work and impairing the health and well‐being of employees. This article is reviewing the literature on the relations between lean and employees, and suggests ways for the development of an employee‐supportive lean practice. There is good evidence of lean's adverse consequences for low‐skilled employees in the auto industry and other assembly type manufacturing work, but there are also examples of more positive outcomes. It is important to emphasize that, not only lean thinking, but also the context and implementation of lean have consequences for employee outcomes. Research is still needed to demonstrate it in real life, but this analysis of lean thinking, context, and implementation suggests possibilities for developing a lean practice that is genuinely employee‐supportive. © 2011 Wiley Periodicals, Inc.
Aquifer system for potential groundwater resources in Hanoi, Vietnam
Authors: Bui Duong Du , Kawamura Akira , Tong Thanh Ngoc , Amaguchi Hideo , Trinh Thu Minh 
Published: January 2012

AbstractPredictions in Ungauged Basins (PUB) mainly focus on surface water, but there are much higher prediction uncertainties inherent in groundwater. Hanoi depends entirely on groundwater for its domestic water supply. However, the characteristics of the entire Hanoi aquifer system remain poorly understood due to the lack of available data. Recently, we were nominated to construct a hydrogeological database. Using the valuable data contained in this database, this paper comprehensively analyzed the best number of 240 boreholes including well logs and their hydrogeological parameters obtained from pumping tests for the first time in order to identify the entire Hanoi aquifer system and characterize the hydrogeological conditions for potential groundwater resources. Great efforts have been made to establish and analyze the hydrogeological maps, cross sections and the isopach maps of main aquifers’ thickness and transmissibility. As for the results, we found that groundwater mainly exists in the topmost Holocene unconfined aquifer and the shallow Pleistocene confined aquifer (PCA), while cleft and karst water exists in the Neogene water bearing layer and the Mesozoic fractured zones. These aquifers are adequately, quantitatively characterized and evaluated from the viewpoint of potential groundwater resources. We found the PCA serving as the highest groundwater potential and the most important aquifer for the water supply. The findings are indispensable for further groundwater analyses contributing to ensuring the sustainable groundwater development not only in Hanoi but also in poorly gauged or ungauged neighboring basins. Copyright © 2012 John Wiley & Sons, Ltd.
Etcetera
Authors: Sinick Daniel 
Published: January 2012

New Roles for Educators by Rita E. Weath‐ersby, Patricia R. Allen, and Alan R. Blackmer, Jr.Rehabilitation and the Culturally Disadvantaged edited by Joseph T. Kunce and Corrine S. Cope.Job Opportunities for Young Negroes by Adrian A. Paradis. David McKayGuidelines for the Collection, Maintenance, and Dissemination of Pupil RecordsTo Nurture Humaneness: Commitment for the ‘70's edited by Mary‐Margaret Scobey and Grace Graham.A Handbook for Job RestructuringMen in Mid‐Career: A Study of British Managers and Technical Specialists by Cyril Sofer.Measures of Social Psychological Attitudes by John P. Robinson and Phillip R. Shaver.
Re: Views
Authors: Weinrach Stephen G. 
Published: January 2012

Birth Control Methods: A Simplified Presentation for the Mentally Retarded. Produced by Planned Parenthood of Northern New York. Filmstrip with script, flipchart, and 140‐page monograph entitled Sexuality and the Mentally Retarded. Northfield, Ill.: Perennial Education, 1975, $75. (Monograph available separately for $7.50.)Your Changing Body: A Guided Self Exploration. Pat Allen and Lee Ann Lipke. Two cassette tapes and 16‐page guide for parents and teachers. North‐field, Ill.: Perennial Education, 1974, $40.Sex Education and Counseling of Special Groups. The Mentally and Physically Handicapped, Ill and Elderly. Warren J. Johnson. Springfield, Ill.: Charles C Thomas, 1975, 213 pp. $12.50.Sex Education for Disabled Persons, #531, Irving R. Dickman, Public Affairs Pamphlets, 1975, 28 pp. 35¢Developmental Disorders: Assessment, Treatment, Education. Robert B. Johnston and Phyllis R. Magreb, Editors. Baltimore: University Park Press, 1976. 532 pp. $14.50.Diagnosing Learning Disabilities. Wilma Jo Bush and Kenneth W. Waugh, (Second Edition). Columbus, Ohio: Charles E. Merrill, 1976. 357 pp. $10.95.Psychology of Deafness for Rehabilitation Counselors Brian Bolton, Editor. Baltimore: University Park Press, 1976. 156 pp. $14.50.The Diagnosis and Treatment of Alcoholism. Gary G. Forrest. Springfield, Ill.: Charles C Thomas, 1975. 272 pp.The Physically Handicapped Child in Your Classroom. Dorothy Edgington. Springfield, Ill.: Charles C Thomas, 1976. 75 pp. $4.50.Teaching the Learning Disabled: A Combined Task‐Process Approach. Bill R. Gearheart. St. Louis: C. V. Mosby, 1976. 246 pp. $10.50.An Evaluation of Policy‐Related Rehabilitation Research. Monroe Berkowitz, Valerie Englander, Jeffrey Rubin, and John D. Worrall. New York: Praeger, 1975. 221 pp. $16.50.Contemporary Vocational Rehabilitation. Herbert Rusalem and David Malikin, Editors. New York: New York University Press, 1976. 250 pp. $13.50.
Re:Views
Authors: Weinrach Stephen G. 
Published: January 2012

Adventures in Therapy Part I: Actualizing Therapy: Foundations for a Scientific Ethic. Everett L. Shostrom, Lila Knapp, and Robert Knapp.Adventures in Therapy Part I: Handbook for the Personal Orientation Inventory. Robert Knapp.Adventures in Therapy Part I: Individual Psychology in Counseling and Education, Parts I and II, (Distinguished Contributors to Psychology series).Adventures in Therapy Part I: Psychotherapy: The Hazardous Cure. Dorothy Tennov.Adventures in Therapy Part I: R. D. Laing: The Man and His Ideas. Richard I. Evans.Adventures in Therapy Part I: Four Psychologies Applied to Education: Freudian, Behavioral, Humanistic, Transpersonal. Thomas B. Roberts, Editor.Adventures in Therapy Part I: A Complete Guide to Therapy From Psychoanalysis to Behavior Modification. Joel Kovel.Adventures in Therapy Part I: Evaluation of Psychological Therapies—Psychotherapies, Behavior Therapies, Drug Therapies and Their Interactions. Robert L. Spitzer & Donald F. Klein, Editors.Adventures in Therapy Part I: Primer for the Nonmedical Psychotherapist. Joyce A. Bockar.Adventures in Therapy Part I: Cognitive Therapy and the Emotional Disorders. Aaron T. Beck.Adventures in Therapy Part I: Biofeedback Applications in Counseling and Education. David G. Danskin and Timothy J. Lowenstein.
Feminism and Psychological Autonomy: A Study in Decision Making
Authors: Sacks Susan Riemer , Eisenstein Hester 
Published: January 2012

Women seeking to realize the feminist goal of autonomy, defined as self‐interested decision making, encounter conflict and anxiety. This study reports a group experience that used life‐space drawings and force‐field analyses to reduce anxiety and foster autonomous decision making. The 15 women participants in the yearlong study reported at least one action in the area originally designated for decision making. Among the components in the process, participants cited identification with, and support and information from, other group members. The results suggest that for the women in this study, group participation enhanced individual autonomy.Autonomy for me is believing in my own ability to do what I want to do, … then taking productive, creative steps toward fulfilling my own goals. … Autonomy for me is a personal thing, an internal thing, feeling that I have power.*
Systems Techniques in Family Therapy: Two Pragmatic Approaches
Authors: Gladding Samuel T. 
Published: January 2012

Duhl, F.J. The Use of the Chronological Chart in General Systems Family Therapy. Journal of Marital and Family Therapy, 1981, 7, 361–373.Resnikoff, R.R. Teaching Family Therapy: Ten Key Questions for Understanding the Family as Patient. Journal of Marital and Family Therapy, 1981, 7, 135–142.
Empiric antibiotic selection strategies for healthcare‐associated pneumonia, intra‐abdominal infections, and catheter‐associated bacteremia
Authors: Snydman David R. 
Published: January 2012

AbstractInitial selection and early deployment of appropriate/adequate empiric antimicrobial therapy is critical to minimize the significant morbidity and mortality associated with hospital‐ or healthcare‐associated infections (HAIs). Initial empiric therapy that inadequately covers the pathogen(s) causing a serious HAI has been associated with increased mortality, longer hospital stay, and elevated healthcare costs. Moreover, subsequent modification of initial inadequate therapy, later in the disease process when culture results become available, may not remedy the impact of the initial choice. Because of this, it is important that initial empiric therapy covers the most likely pathogens associated with infection in a particular patient, even if this initial regimen turns out to be unnecessarily broad, based on subsequent culture results. The current paradigm for management of serious HAIs is to initiate empiric therapy with a broad‐spectrum regimen covering likely pathogens, based on local surveillance and susceptibility data, and presence of risk factors for involvement of a resistant microorganism. Subsequent modification (de‐escalation) of the initial regimen becomes possible later, when culture results are available and clinical status can be better assessed, 2 to 4 days after initiation of empiric therapy. When possible, de‐escalation and other steps to modify antimicrobial exposure are important for minimizing risk of antimicrobial resistance development. This article examines the general process for selection of initial empiric antibiotic therapy for patients with HAIs, illustrated through 3 case studies dealing with healthcare‐associated pneumonia, complicated intra‐abdominal infection, and catheter‐associated bacteremia, respectively. Journal of Hospital Medicine 2012;7:S2–S12. © 2012 Society of Hospital Medicine
Fullerol antagonizes dexamethasone‐induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell
Authors: Liu Hongjian , Yang Xinlin , Zhang Yi , Dighe Abhijit , Li Xudong , Cui Quanjun 
Published: January 2012

AbstractIncreased oxidative stress is currently considered as a crucial cause of corticosteroid‐induced osteonecrosis. The aim of this study was to evaluate the effect of fullerol, a powerful antioxidant, on adipogenic and osteogenic differentiation of a mouse bone marrow derived multipotent cell line, D1. Upon treatment with dexamethasone, D1 cells containing lipid vesicles were distinguishable from the surrounding cells by Oil Red O staining at day 21. Simultaneous treatment of dexamethasone with antioxidant glutathione or fullerol decreased the number of cells containing lipid vesicles. Treatment with dexamethasone for 7 days resulted in a significant increase in adipogenic markers peroxisome proliferator‐activated receptor gamma and adipocyte protein 2 gene expression and decrease in expression of osteogenic markers runt‐related transcription factor 2 and osteocalcin and antioxidative enzymes superoxide dismutase and catalase as revealed by quantitative real‐time PCR. While glutathione and fullerol both were able to antagonize the effects of dexamethasone, fullerol had a greater effect than glutathione. Staining with a fluorescent dye CM‐H2DCFDA as indicator of cellular reactive oxygen species revealed that the percentage of positively stained cells increased after dexamethasone treatment, and addition of fullerol attenuated this activity. These results indicated that fullerol inhibited adipogenesis and simultaneously enhanced osteogenesis by marrow mesenchymal stem cells possibly through elimination of cellular reactive oxygen species. The results indicated that fullerol can potentially be used for prevention and treatment of corticosteroid‐induced osteonecrosis. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1051–1057, 2012
Determination of δ‐[L‐α‐aminoadipyl]‐L‐cysteinyl‐D‐valine in cell extracts of Penicillium chrysogenum using ion pair‐RP‐UPLC‐MS/MS
Authors: Seifar Reza Maleki , Deshmukh Amit T. , Heijnen Joseph J. , van Gulik Walter M. 
Published: January 2012

Abstractδ‐[L‐α‐Aminoadipyl]‐L‐cysteinyl‐D‐valine (ACV) is a key intermediate in the biosynthesis pathway of penicillins and cephalosporins. Therefore, the accurate quantification of ACV is relevant, e.g. for kinetic studies on the production of these β‐lactam antibiotics. However, accurate quantification of ACV is a challenge, because it is an active thiol compound which, upon exposure to air, can easily react with other thiol compounds to form oxidized disulfides. We have found that, during exposure to air, the oxidation of ACV occurs both in aqueous standard solutions as well as in biological samples. Qualitative and quantitative determinations of ACV and the oxidized dimer bis‐δ‐[L‐α‐aminoadipyl]‐L‐cysteinyl‐D‐valine have been carried out using ion pair reversed‐phase ultra high‐performance liquid chromatography, hyphenated with tandem mass spectrometry (IP‐RP‐UPLC‐MS/MS) as the analytical platform. We show that by application of tris(2‐carboxy‐ethyl)phosphine hydrochloride (TCEP) as the reducing reagent, the total amount of ACV can be determined, while using maleimide as derivatizing reagent enables to quantify the free reduced form only.
Residents' Perception of the 2008 Beijing Olympics: Comparison of Pre‐ and Post‐Impacts
Authors: Lee Soo‐Bum , Lee Choong‐Ki , Kang Jae‐shik , Lee Eun‐Yong , Jeon Yu Jung Jennifer 
Published: January 2012

ABSTRACTThe purpose of this study is to explore any significant differences in residents' perception of the impacts before and after the 2008 Beijing Olympics. The findings of this study revealed that residents' perception of the positive impacts (community investment and improvement of city infrastructure) varied over two points in time, while two negative factors (inflation and tax increase) demonstrated little perceptual change. Residents had high expectations of the benefits that the Olympics would bring to the community, yet those expectations were not met. In fact, the problems caused by the Olympics were neither greater nor lesser than they expected. Copyright © 2012 John Wiley & Sons, Ltd.
Non‐junctional human desmoglein 3 acts as an upstream regulator of Src in E‐cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris
Authors: Tsang Siu Man , Brown Louise , Lin Kuang , Liu Li , Piper Kim , O'Toole Edel A , Grose Richard , Hart Ian R , Garrod David R , Fortune Farida , Wan Hong 
Published: January 2012

AbstractE‐cadherin, a classical cadherin, is an adhesion receptor in adherens junctions and has important functions in cell–cell adhesion and cell signalling. Recently we reported that a desmosomal cadherin, desmoglein 3 (Dsg3), an autoantigen in pemphigus vulgaris (PV), associates with E‐cadherin and activates Src, which results in tyrosine phosphorylation of adherens junction proteins. However, the nature of such an interaction and its role in cell–cell adhesion remain unclear. In this report, we provide direct evidence that it is the detergent‐soluble, non‐desmosomal Dsg3 that regulates the activity of Src and its association with E‐cadherin in adherens junction formation. Modulation of Dsg3 levels, either by Dsg3 silencing or over‐expression, alters Src activity and its association with E‐cadherin. Dsg3 silencing caused retardation of calcium‐induced E‐cadherin junction assembly and a reduction of desmosomal protein expression. Furthermore, we provide evidence that this signalling pathway is involved, at least in part, in the pathophysiology of pemphigus. Along with the reduced expression of Dsg3, loss and disruption of E‐cadherin and a concomitant decreased pSrc signalling was identified in the basal keratinocytes surrounding the blisters in PV. These findings suggest a novel function for Dsg3 in the control of E‐cadherin–Src signalling and cell–cell adhesion. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Robotic‐assisted laparoscopic radical cystectomy in the octogenarian
Authors: Lau Clayton S. , Talug John , Williams Stephen B. , Josephson David Y. , Ruel Nora H. , Chan Kevin G. , Wilson Timothy G. 
Published: January 2012

AbstractBackgroundThe advanced age and comorbidities often associated with bladder cancer patients creates a difficult scenario regarding further management. Robotic‐assisted laparoscopic radical cystectomy (RALRC) has had favorable results as a minimally invasive treatment option. We studied perioperative outcomes of RALRC in octogenarians to discern if there is any added benefit in this patient population.MethodsOne hundred and sixty robotic cystectomies have been performed between October 2003 and June 2010. We identified 24 octogenarians who underwent RALRC and form the cohort of the study.ResultsMean patient age was 84.7 years and mean BMI was 24 kg/m2. Most of the patients in the study had serious medical comorbidities, as 82.6% of them had an ASA classification ≥3 and 95.6% had Charlson scores ≥3. There was one open conversion and two patients had positive surgical margins. There were a total of 45 complications in the study, with 14 major complications observed in the 90‐day period after surgery. There were five patients who had no complications, and two patients expired as a result of multiple organ failure. At 24 months the overall, disease‐free and disease‐specific survivals were 51.1%, 64.3%, and 79%, respectively. The 90‐day mortality rate was 8.7%.ConclusionsOctogenarians undergoing RALRC have a significant risk of morbidity and mortality. The relationship between advanced age and oncologic outcomes or complications needs to be discerned further as it relates to the octogenarian. Further study is needed to delineate the safety and efficacy of this approach. Copyright © 2012 John Wiley & Sons, Ltd.