bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerometer‐based swimming metabolism of smallmouth bass (Micropterus dolomieu)
Authors: Brownscombe Jacob W. , Smith Kurtis , Bzonek Paul A. 
Published: May 2024

AbstractBioenergetics is informative for a range of fundamental and applied resource management questions, but findings are often constrained by a lack of ecological realism due to the challenges of remotely estimating key parameters such as metabolic rate. To enable field applications, we conducted a calibration study with smallmouth bass (Micropterus dolomieu, 0.7–2 kg) surgically implanted with accelerometer transmitters and exposed to a ramp‐Ucrit swimming protocol in a swim tunnel respirometer across a range of water temperatures (6, 12, 18, and 24°C). There was an exponential increase in fish acceleration with swimming speed, and acceleration per speed was higher in smaller fish and female fish, and at colder temperatures. Mass‐specific fish metabolic rate (MO2; mg O2 kg−1 h−1) increased with swimming speed, acceleration, and temperature, and decreased with fish mass, which when combined were strong predictors of MO2. Maximum metabolic rate (MMR) was estimated to peak at 22°C, but maximum sustained swimming speed (Ucrit) remained high at c. 90–100 m s−1 above 20°C, based on second‐order polynomial functions. Aerobic scope (AS) estimates peaked at 20°C (>90% AS at 17–24°C; >50% AS at 11–28°C). Males exhibited marginally higher MMR, AS, and Ucrit than females at higher temperatures. Larger fish generally exhibited higher Ucrit, but smaller fish had a marginally broader performance range (AS, Ucrit) among temperatures, benefiting from higher MMR despite a steeper increase in resting metabolic rate with temperature. These findings enable field studies to estimate metabolic metrics of smallmouth bass in situ to characterize their ecological energetics and inform bioenergetics models.
Marine predators segregate interspecifically by space and time in a sheltered coastal bay
Authors: Murray Taryn S. , Elston Chantel , Smale Malcolm J. , Childs Amber‐Robyn , Dicken Matthew L. , Cowley Paul D. 
Published: May 2024

AbstractMarine predators are vital to the healthy functioning of coastal ecosystems, but to understand their roles, it is necessary to elucidate their movement ecology, particularly in relation to one another. A decade's worth of acoustic telemetry data (2011–2020) from Algoa Bay, South Africa, was investigated to determine how two mesopredatory species (teleosts: dusky kob Argyrosomus japonicus, n = 11, and leervis Lichia amia, n = 16) and two top predatory species (sharks: ragged‐tooth sharks Carcharias taurus, n = 45, and white sharks Carcharodon carcharias, n = 31) used and shared this bay ecosystem. Multi‐annual seasonal fidelity to the bay was exhibited by all species, but differences in residency were observed among species. Similarly, species used space in the bay differently—the teleosts moved less and had movements restricted to the central and western inshore regions of the bay. Conversely, the sharks roamed more, but detections were concentrated in the western part of the bay for C. taurus and in the eastern part of the bay for C. carcharias. Social network analysis showed that species segregated in space and time on a fine scale. However, there was some interaction observed between C. taurus, L. amia, and A. japonicus, but to varying degrees. This is likely because of strong habitat preferences exhibited by each species and predator–prey relationships between these predatory guilds. Results highlight that the sheltered marine Algoa Bay is a resource‐rich environment, supporting multiple predators with different hunting strategies albeit similar prey preferences. Finally, these species are likely afforded some protection by the current Greater Addo Elephant National Park Marine Protected Area in the bay but are vulnerable to fishing pressure when they leave this ecosystem.
Bile acid–microbiota crosstalk in hepatitis B virus infection
Authors: Wang Jiaxin , Xu Huimin , Liu Zixin , Cao Yutong , Chen Siyu , Hou Ruifang , Zhou Yun , Wang Yandong 
Published: May 2024

AbstractHepatitis B virus (HBV) is a hepatotropic non‐cytopathic virus characterized by liver‐specific gene expression. HBV infection highjacks bile acid metabolism, notably impairing bile acid uptake via sodium taurocholate cotransporting polypeptide (NTCP), which is a functional receptor for HBV entry. Concurrently, HBV infection induces changes in bile acid synthesis and the size of the bile acid pool. Conversely, bile acid facilitates HBV replication and expression through the signaling molecule farnesoid X receptor (FXR), a nuclear receptor activated by bile acid. However, in HepaRG cells and primary hepatocytes, FXR agonists suppress HBV RNA expression and the synthesis and secretion of DNA. In the gut, the size and composition of the bile acid pool significantly influence the gut microbiota. In turn, the gut microbiota impacts bile acid metabolism and innate immunity, potentially promoting HBV clearance. Thus, the bile acid–gut microbiota axis represents a complex and evolving relationship in the context of HBV infection. This review explores the interplay between bile acid and gut microbiota in HBV infection and discusses the development of HBV entry inhibitors targeting NTCP.
The role of visuomotor synchrony on virtual full‐body illusions in children and adults
Authors: Dewe Hayley , Sill Oscar , Thurlbeck Simon , Kentridge Robert W. , Cowie Dorothy 
Published: May 2024

AbstractThe present study explored the effects of visuomotor synchrony in virtual reality during the embodiment of a full human avatar in children (aged 5–6 years) and adults. Participants viewed their virtual bodies from a first‐person perspective while they moved the body during self‐generated and structured movement. Embodiment was measured via questions and psychophysiological responses (skin conductance) to a virtual body‐threat and during both movement conditions. Both children and adults had increased feelings of ownership and agency over a virtual body during synchronous visuomotor feedback (compared to asynchronous visuomotor feedback). Children had greater ownership compared to adults during synchronous movement but did not differ from adults on agency. There were no differences in SCRs (frequency or magnitude) between children and adults, between conditions (i.e., baseline or movement conditions) or visuomotor feedback. Collectively, the study highlights the importance of visuomotor synchrony for children's ratings of embodiment for a virtual avatar from at least 5 years old, and suggests adults and children are comparable in terms of psychophysiological arousal when moving (or receiving a threat to) a virtual body. This has important implications for our understanding of the development of embodied cognition and highlights the considerable promise of exploring visuomotor VR experiences in children.
Study of the soothing effects of troxerutin in alleviating skin sensitivity
Authors: Kim Tae‐Yoon , Myoung Joonoh , Lee Youn Jung , Lee Jinyong , Kim Jongwook , Kim Seungeun , Kim Mi‐Sun , Beck Bo Ram , Hwang Seung Jin , Kang Nae‐Gyu , Jeong Eui Taek 
Published: May 2024

AbstractBackgroundTransient receptor potential vanilloid 1 (TRPV1) is associated with skin sensitivity and mainly activated by capsaicin and heat. Interestingly, troxerutin can inhibit TRPV1 activation. However, its efficacy in reducing skin sensitivity remains undetermined.AimsWe evaluated the efficacy of troxerutin in alleviating skin sensitivity using clinical tests and in vitro experiments.MethodsFor the in vitro experiment, HaCaT keratinocytes were pretreated with different concentrations of troxerutin, followed by incubation with 50 μM capsaicin for 1, 24, or 48 h. The gene and protein expressions of four inflammatory cytokines involved in skin irritation were determined. Among 35 Korean women with sensitive skin recruited for the clinical trial, 13 were involved in assessing the immediate soothing effects of 0.1% and 0.0095% troxerutin following capsaicin irritation, whereas 22 participated in evaluating the preventive soothing effect of 10% and 1% troxerutin over 4 weeks against capsaicin‐ and heat‐induced irritation. We evaluated the soothing rate using skin redness, visual analog scale, and high temperature sensitive index as evaluation indices.ResultsTroxerutin inhibited the mRNA and protein expressions of cytokines in capsaicin‐treated keratinocytes. In the clinical study, 0.1% and 0.0095% troxerutin promptly alleviated capsaicin‐induced skin redness, whereas 10% troxerutin notably decreased both the visual analog scale and high temperature sensitive index for capsaicin‐ and heat‐related irritation. However, 1% troxerutin was only effective in reducing the visual analog scale in response to capsaicin irritation.ConclusionsTroxerutin can inhibit TRPV1 activation in clinical and in vitro tests.
Marketing innovations and digital technologies: A systematic review, proposed framework, and future research agenda
Authors: Athaide Gerard A. , Jeon Jaihyun , Raj S. P. , Sivakumar K. , Xiong Guiyang 
Published: May 2024

AbstractIn recent years, scholars and practitioners have increasingly recognized the profound impact of digital technologies (DTs) on reshaping organizations' value propositions and their ability to create, communicate, and deliver value to stakeholders. Given this heightened attention, it is imperative to comprehensively examine how DTs affect marketing innovations. This study reports the results of a systematic review of empirical research on DTs' role in marketing innovations. Specifically, it identifies a comprehensive list of technologies and investigates their relevance in enabling innovative approaches within marketing research, strategy formulation (segmentation, targeting, and positioning), and implementation (product, promotion, place, and price). The study synthesizes emerging themes in the literature, pinpoints research gaps, proposes a 3As framework for classifying DTs in marketing, and delineates future research directions in this pivotal domain.
Rethinking eco‐evo studies of gene expression for non‐model organisms in the genomic era
Authors: Freedman Adam H. , Sackton Timothy B. 
Published: May 2024

AbstractRecent advances in genomic technology, including the rapid development of long‐read sequencing technology and single‐cell RNA‐sequencing methods, are poised to significantly expand the kinds of studies that are feasible in ecological genomics. In this perspective, we review these new technologies and discuss their potential impact on gene expression studies in non‐model organisms. Although traditional RNA‐sequencing methods have been an extraordinarily powerful tool to apply functional genomics in an ecological context, bulk RNA‐seq approaches often rely on de novo transcriptome assembly, and cannot capture expression changes in rare cell populations or distinguish shifts in cell type abundance. Advancements in genome assembly technology, particularly long‐read sequencing, and improvements in the scalability of single‐cell RNA‐sequencing (scRNA‐seq) offer unprecedented resolution in understanding cellular heterogeneity and gene regulation. We discuss the potential of these technologies to enable disentangling differential gene regulation from cell type composition differences and uncovering subtle expression patterns masked by bulk RNA‐seq. The integration of these approaches provides a more nuanced understanding of the ecological and evolutionary dynamics of gene expression, paving the way for refined models and deeper insights into the generation of biodiversity.
Druzification from below: The case of Arameans in the north Israel
Authors: Woźniak‐Bobińska Marta 
Published: May 2024

AbstractThis article sheds new light on the Aramean movement in northern Israel, drawing from studies on nationalism, racialisation, ethnic conflict and minority mobilisation. In 2014, Israel allowed members of several churches to identify as Aramean. The pivotal role in the Aramean minority's distancing of itself from the Arab identity was played by the Israeli Christian Aramaic Association (ICAA). Specifying and partially adapting Yusri Hazran's concept of ‘Druzification’, meaning the Israelis' conscious policy of minoritising indigenous populations and encouraging their conscription to the army, the term ‘Druzification from below’ is proposed to stress the bottom‐up character of the Aramean movement in the north of the country as well as the agency of Middle Eastern Christians. My general standpoint is that ‘Druzification from below’ can be perceived as an adaptive strategy—a survival response to structural political conditions and urbicidal practices of the ethnocratic state and adaptation to external threats.
Efficacy of prasugrel versus clopidogrel for early neurological deterioration in branch atheromatous disease: An exploratory study
Authors: Inoue Hiroyasu , Oomura Masahiro , Madokoro Yuta , Taniguchi Yoko , Suzuki Kengo , Sato Toyohiro , Fujioka Teppei , Mizuno Masayuki , Kawashima Shoji , Okita Kenji , Yoshimura Kenichi , Matsukawa Noriyuki 
Published: May 2024

AbstractBackgroundDual antiplatelet therapy (DAPT) with clopidogrel is one of the initial treatment regimens for early neurological deterioration (END) in branch atheromatous disease (BAD). However, its effectiveness is affected by cytochrome P450 2C19 polymorphism. Prasugrel, with reduced cytochrome P450 2C19 interactions, has been approved for cerebrovascular diseases in Japan.AimTo explore the efficacy of DAPT with prasugrel and with clopidogrel in preventing END.MethodsPatients with BAD, admitted within 48 h of symptom onset between June 2022 and September 2023, were enrolled. The primary endpoint was the proportion of patients with END within 7 days, which was defined as an increase of 1 point or more on the National Institutes of Health Stroke Scale (NIHSS). Patients meeting specific magnetic resonance imaging (MRI) criteria, including lesions of ≥15 mm in the lenticulostriate artery (LSA) region or infarcts extending to the ventral side of the paramedian pontine region, were included. The patients were randomly assigned to the clopidogrel with loading and prasugrel without loading groups and administered common medications.ResultsThe study included 9 and 10 patients in clopidogrel and prasugrel groups, of whom 56% and 50% had END, respectively. The prasugrel group had earlier exacerbations after admission (days 0–1) than that of the clopidogrel group (days 1–2). The bleeding complications of both groups were not significantly different.ConclusionThe two groups had similar proportions of patients with END, suggesting comparable efficacies of both drugs for patients with BAD.
Staphylococcus warneri, an unconventional plant pathogen involved in canker disease of almond and other Prunus species
Authors: Asadi Esmaeil , Rahimian Heshmatollah , Babaeizad Valiollah , Basavand Esmaeil 
Published: May 2024

AbstractBacterial canker disease of stone fruits is a major concern in stone fruit‐growing countries worldwide. Pseudomonas spp. and Xanthomonas arboricola pv. pruni (Xap) are the primary pathogens involved in this disease. In spring, summer and autumn 2016, symptoms like those produced by Pseudomonas spp. and Xap were observed in almond, apricot, peach and nectarine orchards in central provinces of Iran (Qom, Isfahan, and Chaharmahal and Bakhtiari). Gram‐positive cocci bacterial isolates were obtained from symptomatic trees. Following hypersensitivity and pathogenicity tests, isolates were divided into pathogenic and nonpathogenic groups, demonstrating the pathogenicity of some isolates on saplings of almond, peach and apricot. Multilocus sequence analysis was performed using the partial sequence of 16S rRNA region and four housekeeping genes, namely tuf, gap, dnaJ and rpoB, to determine the taxonomic classification of isolates, and revealed that pathogenic isolates identified as Staphylococcus warneri, while nonpathogenic isolates identified as S. warneri, S. epidermidis, S. hominis and S. saprophyticus. The isolates were further characterized by phenotypic and biochemical tests as well as by antibiotics assays. The unusual nature of the identified microorganism in the present study lies in the fact that, unlike most plant‐pathogenic agents, S. warneri is recognized worldwide as a cause of bacterial infections in humans and animals. Taken together, the bacterial canker disease caused by S. warneri appears to be a newly emerging disease of apricot, peach and almond trees.
On the Exclusionary Scope of Razian Reasons
Authors: Moreso J. J. 
Published: May 2024

AbstractThis article attempts to illustrate the originality, depth, and farsightedness of Joseph Raz's conception, especially his idea that legal norms provide us with protected reasons to act, that is, with first‐order reasons to behave as they prescribe, and with second‐order, exclusionary reasons not to act for reasons against what they prescribe. But the article also highlights some aspects that raise doubts in my mind, especially with regard to the scope of these exclusionary reasons. This in two ways: by asking, on the one hand, in what sense and subject to what limits legal norms provide exclusionary reasons for the organs entrusted with applying the law, especially for judges, and on the other hand, how and to what extent legal norms provide citizens with exclusionary reasons. So, in recognizing the strength of the Razian conception, the article also points to some of the difficulties it faces.
Partisanship is why people vote in person in a pandemic
Authors: Kim Seo‐Young Silvia , Bandreddi Akhil , Alvarez R. Michael 
Published: May 2024

AbstractObjectiveThe choice of voting methods has increasingly become a politicized, partisan issue. We ask: Can a nationalized partisan rhetoric cast doubt on vote‐by‐mail (VBM) despite years of experience and a raging pandemic?MethodUsing 2020 general election records in Colorado, an established all‐mail voting state, we analyze first the general choice of voting methods using supervised machine learning and then the choice to switch to in‐person voting despite having used VBM in previous cycles.ResultsThe choice of voting modes is mainly habitual; local variations of COVID‐19 hardly mattered. Republican partisanship played an important role in predicting “switchers” to in‐person voting; the probability was 5.2 percent conditional on being a Republican as opposed to 1.9 percent for a Democrat.ConclusionsThe results suggest that voting in person can be heavily polarized by partisan communication, despite being a health behavior in a pandemic and voters having experience with mail voting.
A chromosome‐scale assembly of Brassica carinata (BBCC) accession HC20 containing resistance to multiple pathogens and an early generation assessment of introgressions into B. juncea (AABB)
Authors: Paritosh Kumar , Rajarammohan Sivasubramanian , Yadava Satish Kumar , Sharma Sarita , Verma Rashmi , Mathur Shikha , Mukhopadhyay Arundhati , Gupta Vibha , Pradhan Akshay K. , Kaur Jagreet , Pental Deepak 
Published: May 2024

SUMMARYBrassica carinata (BBCC) commonly referred to as Ethiopian mustard is a natural allotetraploid containing the genomes of Brassica nigra (BB) and Brassica oleracea (CC). It is an oilseed crop endemic to the northeastern regions of Africa. Although it is under limited cultivation, B. carinata is valuable as it is resistant/highly tolerant to most of the pathogens affecting widely cultivated Brassica species of the U's triangle. We report a chromosome‐scale genome assembly of B. carinata accession HC20 using long‐read Oxford Nanopore sequencing and Bionano optical maps. The assembly has a scaffold N50 of ~39.8 Mb and covers ~1.11 Gb of the genome. We compared the long‐read genome assemblies of the U's triangle species and found extensive gene collinearity between the diploids and allopolyploids with no evidence of major gene losses. Therefore, B. juncea (AABB), B. napus (AACC), and B. carinata can be regarded as strict allopolyploids. We cataloged the nucleotide‐binding and leucine‐rich repeat immune receptor (NLR) repertoire of B. carinata and, identified 465 NLRs, and compared these with the NLRs in the other Brassica species. We investigated the extent and nature of early‐generation genomic interactions between the constituent genomes of B. carinata and B. juncea in interspecific crosses between the two species. Besides the expected recombination between the constituent B genomes, extensive homoeologous exchanges were observed between the A and C genomes. Interspecific crosses, therefore, can be used for transferring disease resistance from B. carinata to B. juncea and broadening the genetic base of the two allotetraploid species.
Otherness and cultural conceptualisations of Gender and Social Class in Nigerian English
Authors: Taiwo Rotimi 
Published: May 2024

AbstractStudies of varieties of English have focused on cultural conceptualisations in different varieties, showing how these are deeply rooted in culture. Likewise, several other studies have reported discourses of otherness. This study is an exploration of the intersection of these two concepts – otherness and conceptualisations. Using data from Nigerian English, the study demonstrates how othering and categorisations could derive from cultural conceptualisations of Gender and Social Class. The study discusses selected Nigerian English expressions from the data and offers explanations on how their construction and usage for otherness can be said to derive from cultural conceptualisations. The findings reveal an antipodal portrayal of women as agents with capacity to control men, deprive other women of their husbands, nurture and provide for the society. Cultural conceptualisations of social class based on possessions, diet, experience, locations and how these variables serve as the bases for otherness are equally discussed.
Stem cell‐derived cardiomyocyte heterogeneity confounds electrophysiological insights
Authors: Clark Alexander P. , Krogh‐Madsen Trine , Christini David J. 
Published: May 2024

AbstractHuman induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) offer potential as an in vitro model for studying drug cardiotoxicity and patient‐specific cardiovascular disease. The inherent electrophysiological heterogeneity of these cells limits the depth of insights that can be drawn from well‐designed experiments. In this review, we provide our perspective on some sources and the consequences of iPSC‐CM heterogeneity. We demonstrate the extent of heterogeneity in the literature and explain how such heterogeneity is exacerbated by patch‐clamp experimental artifacts in the manual and automated set‐up. Finally, we discuss how this heterogeneity, caused by both intrinsic and extrinsic factors, limits our ability to build digital twins of patient‐derived cardiomyocytes.
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Adolescentes con personalidad: estudio de caso y propuestas de mejora de una experiencia de transmisión de valores a través del cine
Authors: Ahedo Ruiz Josu , Fuentes Juan Luis , Millán Ghisleri Elda María 
Published: May 2024

Resumen: El cine es un recurso de narrativa audiovisual que puede ser utilizado pedagógicamente para la transmisión de valores en la formación ético-cívica de los adolescentes. Despierta sentimientos y emociones, facilitando conectar con el mundo interior del espectador, quien es interpelado por los diferentes personajes. Las experiencias didácticas fundamentadas en el uso del cine son cada vez más frecuentes en cuanto que facilitan el análisis de modelos y promueven el diálogo y la reflexión sobre valores éticos. Adolescentes con Personalidad es un proyecto de educación en valores a través de películas y textos para jóvenes entre 12 y 17 años, que ha tenido una rápida y significativa expansión tanto en el contexto español como en el latinoamericano, encontrándose en la actualidad en 17 países.