bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testudodinium gen. nov. (Dinophyceae), a new genus of sand‐dwelling dinoflagellates formerly classified in the genus Amphidinium
Authors: Horiguchi Takeo , Tamura Maiko , Katsumata Kazuhito , Yamaguchi Aika 
Published: May 2012

SUMMARYA new genus of sand‐dwelling photosynthetic dinoflagellate, Testudodinium Horiguchi, Tamura, Katsumata et A. Yamaguchi is proposed based on Testudodinium testudo (Herdman) Horiguchi, Tamura, Katsumata, et A. Yamaguchi comb. nov. (Basionym: Amphidinium testudo Herdman) and a new species in this new genus, Testudodinium maedaense Katsumata et Horiguchi sp. nov. is described. Amphidinium corrugatum is also transferred to this genus, making a new combination T. corrugatum (Larsen et Patterson) Horiguchi, Tamura et A. Yamaguchi. These three species are similar to the members of the genus Amphidinium in having an extremely small episome and a dorsoventrally flattened cell body. They are, however, distinguished from the genus Amphidinium seusu stricto by the possession of a distinct longitudinal furrow in the middle of ventral side of the episome. Phylogenetic trees based on small subunit (SSU) rDNA revealed that all three of these Testudodinium species formed a robust clade and, although statistical support is not high, the tree suggests Testudodinium clade is not closely related to Amphidinium seusu stricto clade. The morphological differences together with molecular data support the establishment of a new genus for A. testudo and its related species.
Clients' perceptions of opioid substitution treatment: An input to improving the quality of treatment
Authors: Deering Daryle , Horn Jacqueline , Frampton Christopher M. A. 
Published: May 2012

ABSTRACTDespite the emphasis on providing high quality mental health and addiction treatment, there has been relatively little consideration given to examining clients' perceptions of addiction treatment (consumer satisfaction) as a quality improvement strategy. The present article reports on a survey of a representative sample of 93 clients receiving opioid substitution treatment (OST). Employed participants reported higher treatment satisfaction and a pattern of positive associations was found between satisfaction and general health, mental health, social functioning, lower methadone doses, and participants' ratings of their treatment progress. Lower satisfaction was associated with higher frequency of benzodiazepine use, and, for women, longer treatment duration. Māori participants rated their treatment progress as lower than that of non‐Māori. Results strongly endorse recording participants' comments to provide a deeper understanding of survey item ratings. The study findings highlight the need for a research focus on the roles of mental health and other registered nurses who work with people receiving OST in specialist service and primary care settings, and endorse a partnership approach to future research in this area. The pattern of findings arising from this study suggests key strategies for improving the flexibility and client responsiveness of OST.
Mortality rates for extremely low‐birthweight infants: A regional, population‐based study in Japan during 2005–2009
Authors: Kaneko Masatoki , Sameshima Hiroshi , Kai Katsuhide , Urabe Hirotoshi , Kodama Yuki , Ikenoue Tsuyomu 
Published: May 2012

AbstractAim:  We investigated neonatal and infant mortality rates for extremely low‐birthweight infants and clarified clinical factors associated with death.Material and Methods:  A population‐based study was conducted for 195 infants born from 2005 to 2009.Results:  The infant mortality rate was 28.6%, 21.7%, 34.2%, 6.7%, 6.3%, 13%, and 4.8% at 22, 23, 24, 25, 26, 28, and ≥28 weeks, respectively. The infant mortality rate according to birthweight was 50%, 9%, 31%, 16.7%, 19.4%, 7.5%, and 2.9% for <400 g, 400–499 g, 500–599 g, 600–699 g, 700–799 g, 800–899 g, and 900–999 g, respectively. Log–rank tests revealed a significant difference in the cumulative survival rates according to gestational age (P < 0.001). In the 24‐week group, this rate in a tertiary center was higher than in a non‐tertiary center (P = 0.001). The mortality of infants born by cesarean section (73%) was lower than that of infants born vaginally (P < 0.05). Multiple regression analyses show that the significant factors associated with death were 22–24 weeks of gestational age, management at non‐tertiary centers, and multiple births.Conclusion:  Survival of infants (<1000 g) depends on gestational age, centralization and multiple births.
Vaginal myomectomy is a safe and feasible procedure: A retrospective study of 46 cases
Authors: Rolli Riccardo , Favilli Alessandro , Acanfora Marta Maddalena , Scuderi Gaetano , Di Renzo Gian Carlo , Gerli Sandro 
Published: May 2012

AbstractAim:  The aim of this study was to establish the feasibility and safety of vaginal myomectomy via posterior colpotomy in a series of consecutive procedures performed by one surgeon.Material and Methods:  We conducted a retrospective study in a tertiary care university hospital, involving 46 patients with symptomatic myomas and uteruses smaller than 16 gestational weeks and with no signs of pelvic disease. After a presurgical study, the patients underwent vaginal myomectomy. Characteristics of patients, position and size of myomas, operative data, intraoperative and postoperative complications, and length of hospital stay were recorded.Results:  Forty‐four women underwent vaginal myomectomy and conversion to laparotomy was required in two cases (4.3%). Two patients suffered from infertility and one of these achieved pregnancy after the procedure. The median size of myomas was 50 mm (range 16–81). In two cases a culdoscopy was performed with a flexible fiberoptic gastroscope to better evaluate size and localization of myomas. Thirty‐two patients underwent vaginal myomectomy under general anesthesia and 12 under locoregional anesthesia. The median vaginal operating time was 70 min (range 30–120). The estimated hemoglobin loss was 0.70 g/dL (range 0.40–3.35 g/dL). No severe intraoperative complications occurred. The median duration of hospital stay was 1 day (range 1–6).Conclusions:  Vaginal myomectomy is a safe and feasible surgical procedure if performed by a well‐trained, experienced surgeon.
Pilot study of CD147 protein expression in epithelial ovarian cancer using monoclonal antibody 12C3
Authors: Ueda Kazu , Yamada Kyosuke , Kiyokawa Takako , Iida Yasushi , Nagata Chie , Hamada Tomomi , Saito Misato , Aoki Katsuhiko , Yanaihara Nozomu , Takakura Satoshi , Okamoto Aikou , Ochiai Kazunori , Ohkawa Kiyoshi , Tanaka Tadao 
Published: May 2012

AbstractAim:  CD147 is a membrane glycoprotein that is expressed in various cancer cells and is involved in tumor invasion and metastasis by inducing stromal fibroblastic cells to produce matrix metalloproteinases. This study was carried out to evaluate the correlation between CD147 expression and various clinicopathologic parameters, including histological grade and prognosis in a small sample set of human ovarian cancer patients.Material and Methods:  Paraffin‐embedded surgical tissue samples from 25 patients with ovarian serous and endometrioid adenocarcinoma were stained with anti‐CD147 antibody (monoclonal antibody 12C3: MoAb 12C3) for immunohistochemical analysis.Results:  CD147 protein was expressed in 84.0% (21 of 25 cases) of cancerous lesions, but not in normal lesions. CD147 expression by ovarian cancer cells was inversely correlated with overall survival. There was no correlation between CD147 expression and histological grade.Conclusions:  These results suggest that measurement of CD147 expression may enhance the understanding of the pathophysiology of epithelial ovarian cancer.
Diagnosis and treatment of postpartum Candida endophthalmitis
Authors: Lee Jae Hyung , Kim Jung Sub , Park Young‐Hoon 
Published: May 2012

AbstractThe occurrence of endogenous Candida endophthalmitis is rare in immunocompetent patients. We report a case of a 29‐year‐old healthy woman who developed endogenous Candida endophthalmitis after normal spontaneous vaginal delivery. The patient was diagnosed with Candida endophthalmitis by positive vitreous culture obtained by diagnostic vitrectomy. After vitrectomy, she was treated with systemic and intravitreal antifungal therapy, and subsequently, her visual acuity recovered to 20/20 without other complications. Normal spontaneous vaginal delivery may cause endogenous Candida endophthalmitis in young healthy women. Diagnostic vitrectomy with systemic and intravitreal antifungal treatment can be useful in diagnosis and treatment of Candida endophthalmitis.
Tuberculosis in pregnancy: The challenges for South Asian countries
Authors: Jana Narayan , Barik Sukumar , Arora Nalini , Singh Arun Kumarendu 
Published: May 2012

AbstractAim:  Despite tuberculosis (TB) being a global problem, maternal TB remains an unrecognized and underestimated tragedy, especially in South Asian countries. Therefore, we performed a non‐systematic review regarding implications of maternal TB on obstetric and perinatal outcomes in the South Asian context.Material and Methods:  We reviewed original studies, both descriptive and analytical, that originated from South Asian countries following an electronic search supplemented by a manual search. Although relevant studies from developed countries were reviewed, they were not included in the tabulation process because those studies had different socioeconomic/epidemiological background.Results:  Diagnosis of TB is often delayed during pregnancy, because of its non‐specific symptoms, and overlapping presentation with other infectious diseases. Poverty, undernutrition, lack of social support and poor health infrastructure along with complications of TB and need for prolonged medications lead to increased maternal morbidity and mortality. Maternal TB in general (except lymphadenitis), is associated with an increased risk of small‐for‐gestational age, preterm and low‐birthweight neonates, and high perinatal mortality. These adverse perinatal outcomes are even more pronounced in women with advanced disease, late diagnosis, and incomplete or irregular drug treatment. There could be a synergy of TB, socioeconomic and nutritional factors, which might have contributed to adverse perinatal effects, especially in low‐income countries.Conclusions:  As active TB poses grave maternal and perinatal risks, early, appropriate and adequate anti‐TB treatment is a mainstay for successful pregnancy outcome. The current knowledge gaps in perinatal implications of maternal TB can be addressed by a multicenter comparative cohort study.
Association between self‐reported questionnaire data on fertility and results of hormone analyses in women after childhood cancer: A cross‐sectional study
Authors: Jantke Andreas , Rendtorff Rosa , Dittrich Ralf , Müller Andreas , Pfitzer Constanze , Hohmann Cynthia , Keil Thomas , Borgmann‐Staudt Anja 
Published: May 2012

AbstractAim:  The aim of this study was to compare self‐reported questionnaire‐based information on fertility impairment with results from hormone analyses in women who underwent chemoradiotherapy during childhood and adolescence.Material and Methods:  In a cross‐sectional study, questionnaires and hormone analyses (anti‐Müllerian hormone [AMH], follicle‐stimulating hormone, luteinizing hormone, estradiol, progesterone) were evaluated in 86 female former pediatric oncology patients in Berlin in 2009.Results:  Eighty‐six women (median age 23 years, range 19–41) participated in the study with a median follow up of 14 years (range 2–30) after diagnosis. Among women with information on permanent and transient amenorrhea, 9% (5/55) of the women stated that they were permanently amenorrheic. Among women not taking oral contraceptives and giving information on the regularity of their menstrual cycle, 18% (4/22) had an irregular menstrual cycle and 82% (18/22) had a regular menstrual cycle. The median AMH values for women who were categorized as infertile by questionnaire‐based information were significantly lower than the AMH values of women who were categorized as fertile by questionnaire (0.05 vs 2.2 ng/mL, P = 0.004). Questionnaire‐based categories on the regularity of the menstrual cycle and categories based on AMH values showed a satisfying percentage agreement (66.7%) and were moderately correlated (r = 0.42, P = 0.002).Conclusion:  Self‐reported questionnaire data used to detect fertility impairment has limited correspondence with objectively measured AMH values.
Combination of squamous cell carcinoma‐antigen, carcinoembryonic antigen, and carbohydrate antigen 19‐9 predicts positive pelvic lymph nodes and parametrial involvement in early stage squamous cell carcinoma of the uterine cervix
Authors: Ikeda Shun‐ichi , Yoshimura Kenichi , Onda Takashi , Kasamatsu Takahiro , Kato Tomoyasu , Ishikawa Mitsuya , Sasajima Yuko , Tsuda Hitoshi 
Published: May 2012

AbstractAim:  We examined the correlations between the pretreatment values of four tumor markers (squamous cell carcinoma [SCC]‐antigen, carcinoembryonic antigen [CEA], carbohydrate antigen [CA]19‐9, and CA125) and postsurgical high‐risk factors (parametrial involvement and positive pelvic lymph nodes) in women with SCC of the uterine cervix who had International Federation of Gynecology and Obstetrics clinical stage IB and IIA disease and underwent radical hysterectomy.Material and Methods:  In this retrospective study, we reviewed 291 patients between April 1989 and December 2008. The first 200 subjects, studied between 1989 and 2001, served as the training set, and another 91 subjects, studied between 2002 and 2008, comprised the test set. To evaluate the correlations between pretreatment tumor markers and postsurgical high‐risk factors, the χ2‐test and logistic regression analysis were used for univariate and multivariate analysis, respectively.Results:  Multivariate analysis with receiver–operator curves showed that the combination of SCC‐antigen, CEA, and CA19‐9 strongly predicted postsurgical high‐risk factors. Analysis of the training set showed that 66.7% (95% confidence interval, 52.6–84.8%) of patients who tested positive for at least two of these three tumor markers had postsurgical high‐risk factors. Similar results were obtained with the test set.Conclusions:  Preoperative levels of SCC‐antigen, CEA, and CA19‐9 are useful for predicting the status of postsurgical high‐risk factors in women with SCC of the uterine cervix who undergo radical hysterectomy.
Photoperiodic modulation of the hepatic clock by the suprachiasmatic nucleus and feeding regime in mice
Authors: Parkanová Daniela , Nováková Marta , Sosniyenko Serhiy , Sumová Alena 
Published: May 2012

AbstractChanges in photoperiod modulate the central circadian clock in the suprachiasmatic nucleus (SCN) as well as the peripheral clocks. Consequently, the SCN‐driven output rhythms in activity and feeding are also modulated by the photoperiod. The aim of the present study was to elucidate whether photoperiodic modulation of the hepatic clock is mediated by changes in feeding or by another SCN‐driven pathway. Five days after the change from short photoperiod (SP) to long photoperiod (LP), the profiles of Per2 and Rev‐erbα expression in the rostral, middle and caudal regions of the SCN were desynchronized and those in the liver were modulated as in mice fully entrained to LP. The SCN profiles were not affected in mice left under SP and subjected to the 6‐h night‐time feeding regime for 5 days. In the liver, the profiles were shifted to the same phase, but their waveforms were not modulated compared with those under LP. In mice subjected to the change from SP to LP and fed twice daily during the daytime, the profiles in the SCN were not affected, whereas the waveforms and phases of those in the liver were affected. The data demonstrate that the adjustment of gene expression profiles in the rostral, middle and caudal SCN to the change from SP to LP proceeds within 5 days and is not affected by changes in the feeding regime. The results also suggest that the photoperiod‐modulated SCN affects waveforms of gene expression profiles in the liver by food‐independent signals.
Dispersal and spatial distribution of western corn rootworm larvae in relation to root phenology
Authors: Schumann Mario , Vidal Stefan 
Published: May 2012

Despite the increasing economic importance of root feeding pests such as the western corn rootworm (WCR) Diabrotica virgifera virgifera, basic parameters about their below ground biology are only partly understood. The present study investigated the dispersal and distribution of WCR larvae in the maize root system during their development at two growth stages of maize (BBCH 13–14 and BBCH 17–18).
Dispersal of the WCR larvae increased as they developed; the larvae moved off their original place of emergence and into deeper soil layers. Overall, changes in the horizontal distribution of the larvae were more extensive than changes in the vertical distribution.
The spatial analysis of distance indices revealed that the larvae had an aggregative distribution throughout their development. The feeding site of larvae in the root system was determined by the stage of larval development. Initially, WCR larvae started feeding in close proximity to their emergence location and moved to more developed root tissue towards the end of their development.
Differences in root phenology mainly influenced the distribution of the larvae at the end of their development, when larvae exhibited increased vertical movement at a later growth stage of maize.
The mechanisms of these distributional changes and the implications for the management of WCR larvae are discussed, especially with regard to chemical control, because fewer larvae are expected to be targeted at a later growth stage of maize.
Randomized, double‐blind, placebo‐controlled trial of the once‐daily GLP‐1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal‐L‐Asia)
Authors: Seino Y. , Min K. W. , Niemoeller E. , Takami A. ,   on behalf of the EFC10887 GETGOAL‐L Asia Study Investigators
Published: May 2012

AimsTo assess the efficacy and safety of once‐daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea.MethodsIn this 24‐week, randomized, double‐blind, placebo‐controlled, parallel‐group, multicentre study, participants (mean baseline HbA1c 8.53%) from Japan, Republic of Korea, Taiwan and the Philippines received lixisenatide (n = 154) or placebo (n = 157) in a stepwise dose increase to 20 µg once daily. The primary endpoint was HbA1c change from baseline to week 24.ResultsOnce‐daily lixisenatide significantly improved HbA1c versus placebo (LS mean difference vs. placebo = −0.88% [95%CI= −1.116, −0.650]; p < 0.0001), and allowed more patients to achieve HbA1c <7.0% (35.6 vs. 5.2%) and ≤6.5% (17.8 vs. 1.3%). Lixisenatide also significantly improved 2‐h postprandial plasma glucose and glucose excursion, average 7‐point self‐monitored blood glucose and fasting plasma glucose. Lixisenatide was well tolerated; 86% of patients on lixisenatide completed the study versus 92% on placebo. Ten (6.5%) lixisenatide and 9 (5.7%) placebo patients experienced serious adverse events. More lixisenatide patients [14 (9.1%)] discontinued for adverse events versus placebo [5 (3.2%)], mainly with gastrointestinal causes. Nausea and vomiting were reported in 39.6 and 18.2% of patients on lixisenatide versus 4.5 and 1.9% on placebo. Symptomatic hypoglycaemia was more frequent with lixisenatide (42.9%) versus placebo (23.6%), but was similar between groups (32.6 vs. 28.3%, respectively), in those not receiving sulfonylureas. No severe hypoglycaemia was reported.ConclusionsIn an Asian type 2 diabetes population insufficiently controlled by basal insulin ± sulfonylurea, once‐daily lixisenatide significantly improved glycaemic control, with a pronounced postprandial effect, and was well tolerated.
TMT Potency and Strategic Decision‐Making in High Technology Firms
Authors: Clark Kevin D. , Maggitti Patrick G. 
Published: May 2012

abstractConfidence is necessary for effective top management team (TMT) functioning, however overconfidence or hubris has been associated with poor outcomes. Researchers have struggled to untangle questions of how much confidence is functional and whether there are different forms of confidence. Using data from a field study of 54 public high‐technology firms we provide a richer understanding of the complex influence of one type of confidence, TMT potency on strategic decision‐making. Specifically, using a field study of TMTs of 54 public high technology firms we find potency at least partially mediates the relationship between TMT experience and knowledge, TMT interaction process, and strategic decision speed. Post‐hoc analysis of high potency teams suggests that potency may be either functional – leading to high performance, or dysfunctional – resulting in low performance. Potency appears to be a multi‐faceted construct consisting of both level and domain boundedness. We offer propositions that begin to untangle the origins of functional versus dysfunctional potency or hubris.
Sexual abuse in bariatric surgery candidates – impact on weight loss after surgery: a systematic review
Authors: Steinig J. , Wagner B. , Shang E. , Dölemeyer R. , Kersting A. 
Published: May 2012

SummaryBariatric surgery is becoming more and more influential as efficient weight loss therapy for the morbidly obese. As many studies propose a relationship between sexual abuse and obesity in general, but especially with regard to weight regain after successful weight loss, sexual abuse might also have a crucial impact on the outcome of the surgical procedures. This review examines the literature comparing weight loss after bariatric surgery in sexually abused and non‐abused individuals. We conducted a systematic electronic literature search covering PubMed/Medline, ScienceDirect, PsychInfo and Web of Science. While 13 studies examined prevalence rates of sexual abuse among bariatric patients, eight studies explicitly investigated the effect of sexual abuse on surgery outcome. We hypothesized that individuals with a history of sexual abuse lose less weight compared to individuals with no such abuse history. At first glance, only three out of eight studies demonstrated significantly reduced weight loss in the sexually abused patients. However, a closer investigation of all studies revealed that patients with abuse experiences may indeed tend to lose less weight initially. Still, this sub‐population apparently benefits from the surgical procedure, as revealed by increased weight loss over time. Reasons for these mixed results are discussed, as well as the clinical implications that can be drawn from these studies.