bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Sikap Cinta Tanah Air Siswa Kelas IV Pada Mata Pelajaran Pendidikan Pancasila di Sekolah Dasar
Authors: Lavita Fera , Awiria  
Published: June 2024

Penelitian ini memiliki tujuan ganda, yaitu (1) mendeskripsikan peran guru SD dalam menerapkan proses pembelajaran PKN untuk mengembangkan sikap cinta tanah air pada siswa kelas IV D di SDN Bahagia 04, dan (2) mendeskripsikan faktor penghambat yang dihadapi siswa kelas IV D dalam mengadopsi sikap cinta tanah air pada mata pelajaran PKN di SDN Bahagia 04. Metode yang digunakan dalam penelitian ini adalah kualitatif, dengan teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Analisis data dilakukan melalui tahap reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa guru di kelas telah berhasil menerapkan indikator sikap cinta tanah air dalam pembelajaran Pendidikan Pancasila. Mereka mengaitkan pembahasan dan contoh dari materi dengan situasi kehidupan sehari-hari siswa, dan menjadikan diri mereka sebagai panutan yang mencerminkan sikap cinta tanah air. Namun, terdapat faktor penghambat yang dihadapi siswa dalam menerapkan sikap cinta tanah air, yaitu kurangnya hafalan lagu-lagu daerah dan nasional. Hafalan lagu-lagu tersebut dijadikan sebagai praktik pembiasan yang dinyanyikan sebelum dan sesudah sesi pembelajaran.
ЕФЕКТИВНІСТЬ УДОБРЕННЯ ПШЕНИЦІ ОЗИМОЇ НА РІЗНИХ ФОНАХ ХІМІЧНИХ МЕЛІОРАНТІВ В УМОВАХ ЗАХІДНОГО ПОЛІССЯ
Authors: Польовий В. М. , Ювчик Н. О. 
Published: June 2024

Наводяться результати економічної та енергетичної оцінки застосування під пшеницю озиму в умовах Західного Полісся на дерново-підзолистому зв'язнопіщаному ґрунті встановлених різними методами доз мінеральних добрив на фоні різних видів і доз хімічних меліорантів. На підставі проведених у 2021–2023 роках польових досліджень встановлено, що на фоні 1,0 ГК дози доломітового борошна без застосування мінеральних добрив зібрано 2,68 т/га зерна, тобто приріст порівняно з контролем склав 31,4 відсотка. Внесення на фоні доломітового борошна рекомендованої для пшениці озимої в зоні Західного Полісся дози мінеральних добрив (N120Р60К90) у комплексі з мікродобривом сприяло підвищенню врожайності до 4,52 т/га, або на 68,6 відсотка порівняно з фоном і 121,6 відсотка порівняно з контролем. Встановлена за нормативами виносу елементів живлення більшим врожаєм зерна 5,00 т/га, яка склала N130Р25К35, збільшувала врожайність по відношенню до фону і контролю відповідно на 63,4 і 114,7 відсотка. За внесення N120Р60К90+мікродобриво на фоні полуторної дози СаMg(СО3)2 порівняно з їх застосуванням на фоні одинарної дози такого ж меліоранта врожайність зерна підвищилась з 4,52 до 4,64 або на 0,12 т/га. Найвищий приріст врожаю зерна – 2,93 т/га порівняно з контролем (2,04), забезпечило внесення розрахованої за нормативами виносу запрограмованого врожаю зерна і відповідної кількості соломи дози мінеральних добрив N150Р50К150+мікродобриво, але самий високий умовно чистий прибуток – 4306,4 грн/га за приросту врожайності по відношенню до контролю 2,34 т/га, отримано на варіанті з внесенням N130Р25К35+мікродобриво. Комплексне застосування азотних, фосфорних, калійних добрив та мікродобрива на фоні вапнування підвищувало коефіцієнт енергетичної ефективності до 4,21–4,37 од. за 3,88 од. на контролі.
Kesulitan Belajar Siswa SMP mengenai Kemampuan Koneksi Matematis pada Materi Statistika
Authors: Permatasari Rani , Nuraeni Reni 
Published: June 2024

Penelitian ini untuk menganalisis kesulitan belajar siswa SMP mengenai kemampuan koneksi matematis pada materi Statistika, menganalisis kesalahan siswa dalam menyelesaikan soal dan mengetahui faktor penyebab siswa mengalami kesulitan belajar. Subjek penelitian adalah siswa SMP kelas IX sebanyak 7 orang. Jenis penelitiannya deskriptif kualitatif. Data diperoleh dari tes tertulis dan wawancara. Hasil penelitian yaitu siswa dengan kemampuan koneksi matematis tinggi tidak mengalami kesulitan belajar konsep, prinsip dan masalah verbal hanya terdapat kesalahan encoding error dalam mengerjakan soal, siswa dengan kemampuan koneksi matematis sedang sedikit mengalami kesulitan belajar konsep dan prinsip serta melakukan kesalahan transformation error, process skills error, dan encoding error; siswa dengan kemampuan koneksi matematis rendah mengalami kesulitan belajar konsep, prinsip dan masalah verbal serta melakukan kesalahan di semua aspek. Penyebab kesulitan belajar dan kesalahan siswa saat mengerjakan soal yaitu tidak menyukai matematika, malas belajar, guru mengajar terlalu cepat, kelas tidak kondusif, perhatian keluarga, teman pergaulan yang tidak mendukung.
This study is to analyze the learning difficulties of junior high school students regarding the mathematical connection ability of the statistics material, to analyze students' errors in solving questions and to find out the factors that cause students to experience learning difficulties. The research subjects were 7 students of grade IX in junior high school. This type of research is descriptive qualitative. Data obtained from written tests and interviews. The results showed that students with high mathematical connection skills did not have difficulty learning concepts, principles and verbal problems, there were only encoding errors in working on questions, students with moderate mathematical connection skills had a little difficulty learning concepts and principles and made transformation errors, process skills errors. , and encoding errors; students with low mathematical connection skills have difficulty learning concepts, principles and verbal problems and make mistakes in all aspects. The causes of learning difficulties and mistakes of students when working on questions are disliking mathematics, lazy learning, teachers teaching too fast, class is not conducive, family attention, unsupportive friends.
The use of portable abdominal bioimpedance analyzer Yscope in the assessment of abdominal obesity
Authors: Gažarová Martina , Lenártová Petra , Ondreičková Monika , Hačková Laura 
Published: June 2024

BackgroundObesity, especially abdominal obesity, is strongly correlated with metabolic and other health risks. Diagnosis and assessment of obesity is important in clinical and routine preventive practice. From the point of view of risk, it is necessary to distinguish not only the area of fat tissue accumulation, but also its type.ObjectiveThe aim of the study was to use a new portable abdominal bioimpedance analyzer, which is intended for the area of abdominal adipose tissue, as part of the evaluation of the body structure of a selected group of volunteers with a focus on the differentiation of subcutaneous and visceral adipose tissue and to assess its usefulness in practice.Material and MethodsBody composition was analyzed using a portable abdominal bioimpedance analyzer Yscope
(PA-BIA) in combination with a bioimpedance device InBody 970 (high-frequency bioelectrical impedance/HF-BIA). Eighty-three volunteers at the age of 24.92±7.24 years with representation of both sexes participated in the study.ResultsAbdominal fat did not differ significantly between the sexes, women reached an average value of 2.01±1.14 kg, men 2.22±1.60 kg (p>0.05). Gender differentiation was manifested in the case of visceral fat (p<0.01) and visceral fat area (p<0.01), the values of which were lower in women than in men. In the case of subcutaneous fat, we found the opposite trend of values in relation to gender, where lower values were achieved by men, but there were no significant differences (p>0.05). Visceral fat was most correlated with abdominal fat (r=0.86) and waist circumference (r=0.85), subcutaneous fat had the strongest positive correlations with abdominal fat (r=0.93) and with body fat mass (r=0.93).ConclusionsPA-BIA in combination with HF-BIA makes it possible to determine the representation of subcutaneous and visceral fat in the abdominal area, which the conventional MFS-BIA method does not allow. When evaluating body composition, significant gender differentiation is confirmed, which is an important factor affecting different health risks related to gender and the representation of different types of fat tissue localized and accumulated in different parts of the body.
Reproductive toxicology of environmental endocrine-disrupting chemicals in women: a cohort study protocol
Authors: Zhang Shuyi , Gao Fumei , Fu Min , Zhang Qiuxiang , Guan Jing , Shen Huan 
Published: June 2024

Introduction: Epidemiological evidence over the last few decades has consistently shown that exposure to endocrine-disrupting chemicals (EDCs) is associated with adverse reproductive health outcomes, including male and female infertility, poor-pregnancy outcomes, and increased risk of diseases in childhood and beyond. To investigate the effects of EDCs and lifestyle on all aspects of reproduction (including early oocyte development, fertilization, embryo development, embryo implantation, abortion, and preterm birth).Methods: We performed this cohort study on patients receiving in vitro fertilization (IVF) treatment. Biological samples including urine, serum, follicular fluid, semen, fetal tissue, decidua, and placenta, were obtained.Results: By studying the correlations between reproductive outcomes and environmental pollutant exposure and lifestyle, we determined the toxicological mechanisms and health effects of EDCs on female reproductive health. We found that higher concentrations of per- and polyfluoroalkyl substances were correlated with polycystic ovary syndrome (PCOS). Using specific biomarkers, we also detected the concentrations of organophosphorus flame retardants (OPFRs) in urine and found that OPFRs may disrupt hormone homeostasis.Discussion: All of these results reveal EDCs may disrupt female reproduction.
Integrating scRNA-seq and bulk RNA-seq to explore the differentiation mechanism of human nail stem cells mediated by onychofibroblasts
Authors: Fang Xia , Zhou Jiateng , Yang Yating , Li Dawei , Wang Bin 
Published: June 2024

Introduction: Nail stem cell (NSC) differentiation plays a vital role in maintaining nail homeostasis and facilitating digit regeneration. Recently, onychofibroblasts (OFs), specialized mesenchymal cells beneath the nail matrix, have emerged as potential regulators of NSC differentiation. However, limited understanding of OFs’ cellular properties and transcriptomic profiles hinders our comprehension of their role. This study aims to characterize human OFs and investigate their involvement in NSC differentiation.Methods: Human OFs were isolated and characterized for their mesenchymal stem cell (MSC)-like phenotype through flow cytometry and multilineage differentiation assays. Bulk RNA-seq analysis was conducted on three samples of OFs and control fibroblasts from human nail units to delineate their molecular features. Integrated analysis with scRNA-seq data was performed to identify key signaling pathways involved in OF-induced NSC differentiation. Co-culture experiments, siRNA transfection, RT-qPCR, and immunocytochemistry were employed to investigate the effect of OF-derived soluble proteins on NSC differentiation. Drug treatments, RT-qPCR, western blotting, and immunocytochemistry were used to verify the regulation of candidate signaling pathways on NSC differentiation in vitro.Results: Human OFs exhibited slow cell cycle kinetics, expressed typical MSC markers, and demonstrated multilineage differentiation potential. Bulk RNA-seq analysis revealed differential gene expression in OFs compared to control fibroblasts, highlighting their role in coordinating nail development. Integrated analysis identified BMP4 as a pivotal signal for OFs to participate in NSC differentiation through mesenchymal-epithelial interactions, with the TGF-beta pathway possibly mediating this signal. OFs synthesized and secreted more BMP4 than control fibroblasts, and BMP4 derived from OFs induced NSC differentiation in a co-culture model. Recombinant human BMP4 activated the TGF-beta pathway in NSCs, leading to cell differentiation, while the BMP type I receptor inhibitor LDN193189 attenuated this effect.Discussion: This study characterizes the cellular and molecular features of human OFs, demonstrating their ability to regulate NSC differentiation via the TGF-beta signaling pathway. These findings establish a connection between the dermal microenvironment and NSC differentiation, suggesting the potential of OFs, in conjunction with NSCs, for developing novel therapies targeting nail and digit defects, even severe limb amputation.
Graphene/ chitosan tubes inoculated with dental pulp stem cells promotes repair of facial nerve injury
Authors: Sun Jingxuan , He Lina , An Qi , Ye Xu , Ma Jinjie , Yan Jing , Xie Xiaoqi , Sun Xiangyu , Niu Yumei , Cao Wenxin 
Published: June 2024

Introduction: Facial nerve injury significantly impacts both the physical and psychological] wellbeing of patients. Despite advancements, there are still limitations associated with autografts transplantation. Consequently, there is an urgent need for effective artificial grafts to address these limitations and repair injuries. Recent years have witnessed the recognition of the beneficial effects of chitosan (CS) and graphene in the realm of nerve repair. Dental pulp stem cells (DPSCs) hold great promise due to their high proliferative and multi-directional differentiation capabilities.Methods: In this study, Graphene/CS (G/CST) composite tubes were synthesized and their physical, chemical and biological properties were evaluated, then DPSCs were employed as seed cells and G/CST as a scaffold to investigate their combined effect on promoting facial nerve injury repair.Results and Disscussion: The experimental results indicate that G/CST possesses favorable physical and chemical properties, along with good cyto-compatibility. making it suitable for repairing facial nerve transection injuries. Furthermore, the synergistic application of G/CST and DPSCs significantly enhanced the repair process for a 10 mm facial nerve defect in rabbits, highlighting the efficacy of graphene as a reinforcement material and DPSCs as a functional material in facial nerve injury repair. This approach offers an effective treatment strategy and introduces a novel concept for clinically managing facial nerve injuries.
Presence of Group A streptococcus frequently assayed virulence genes in invasive disease: a systematic review and meta-analysis
Authors: Rampersadh Kimona , Salie M. Taariq , Engel Kelin C. , Moodley Clinton , Zühlke Liesl J. , Engel Mark E. 
Published: June 2024

IntroductionIt is currently unclear what the role of Group A streptococcus (GAS) virulence factors (VFs) is in contributing to the invasive potential of GAS. This work investigated the evidence for the association of GAS VFs with invasive disease.MethodsWe employed a broad search strategy for studies reporting the presence of GAS VFs in invasive and non-invasive GAS disease. Data were independently extracted by two reviewers, quality assessed, and meta-analyzed using Stata®.ResultsA total of 32 studies reported on 45 putative virulence factors [invasive (n = 3,236); non-invasive (n = 5,218)], characterized by polymerase chain reaction (PCR) (n = 30) and whole-genome sequencing (WGS) (n = 2). The risk of bias was rated as low and moderate, in 23 and 9 studies, respectively. Meta-,analyses of high-quality studies (n = 23) revealed a significant association of speM [OR, 1.64 (95%CI, 1.06; 2.52)] with invasive infection. Meta-analysis of WGS studies demonstrated a significant association of hasA [OR, 1.91 (95%CI, 1.36; 2.67)] and speG [OR, 2.83 (95%CI, 1.63; 4.92)] with invasive GAS (iGAS). Meta-analysis of PCR studies indicated a significant association of speA [OR, 1.59 (95%CI, 1.10; 2.30)] and speK [OR, 2.95 (95%CI, 1.81; 4.80)] with invasive infection. A significant inverse association was observed between prtf1 [OR, 0.42 (95%CI, 0.20; 0.87)] and invasive infection.ConclusionThis systematic review and genomic meta-analysis provides evidence of a statistically significant association with invasive infection for the hasA gene, while smeZ, ssa, pnga3, sda1, sic, and NaDase show statistically significantly inverse associations with invasive infection. SpeA, speK, and speG are associated with GAS virulence; however, it is unclear if they are markers of invasive infection. This work could possibly aid in developing preventative strategies.
Geospatial analysis of cardiovascular mortality before and during the COVID-19 pandemic in Peru: analysis of the national death registry to support emergency management in Peru
Authors: Moya-Salazar Jeel , Marín Eileen A. , Palomino-Leyva Camila B. , Rivera Jhonny , Torre Rosario La , Cañari Betsy , Pardo-Villarroel Claudio , Contreras-Pulache Hans 
Published: June 2024

BackgroundCOVID-19 has led to significant global mortality, with Peru being among the countries most affected. While pre-existing comorbidities have been linked to most cases, the exact distribution of fatalities within the country remains unclear. We aimed to assess deaths attributed to cardiovascular diseases (CVD) before and during the COVID-19 pandemic across various regions and provinces in Peru.MethodsAn observational georeferencing study was designed. Peru faced four waves of COVID-19 over three years, with variable impacts across its three regions (Coast, Highlands, and Jungle). Deaths related to cardiovascular diseases, such as heart failure (HF), arrhythmia, acute myocardial infarction (AMI), strokes, and acute coronary syndrome, were examined as primary variables. The study period spanned pre-pandemic years (2017–2019) and pandemic years (2020–2021), utilizing death data from the National Death Information System (SINADEF). The georeferencing analysis was conducted using ArcGIS v10.3.ResultsA total of 28,197 deaths were recorded during the study period, with significant increases during the pandemic (2020–2021). Cardiovascular deaths were disproportionately higher during the pandemic, totaling 19,376 compared to 8,821 in the pre-pandemic period (p &lt; 0.001). AMI and HF were the leading causes of mortality, showing significant increases from the pre-pandemic (5,573 and 2,584 deaths) to the pandemic period (12,579 and 5,628 deaths), respectively. Deaths due to CVD predominantly affected individuals aged over 60, with significant increases between the two study periods (7,245 vs. 16,497 deaths, p = 0.002). Geospatial analysis revealed regional disparities in CVD mortality, highlighting provinces like Lima and Callao as COVID-19 critical areas. The substantial increase in cardiovascular deaths during the COVID-19 pandemic in Peru showed distinctive patterns across regions and provinces.ConclusionsGeospatial analysis identified higher-risk areas and can guide specific interventions to mitigate the impact of future health crises. Understanding the dynamic relationship between pandemics and cardiovascular health is crucial for effective public health strategies.
Global trends and research hotspots of PCSK9 and cardiovascular disease: a bibliometric and visual analysis
Authors: Tang Masong , Yang Sen , Zou Junying , Li Meng , Sun Yan , Wang Mengqi , Li Wanhan , He Junhui , Chen Ying , Tang Zhanyou 
Published: June 2024

BackgroundCardiovascular disease (CVD) is a prevalent non-communicable disease globally and holds the position of being the primary cause of mortality worldwide. Consequently, considerable focus has been directed towards the prevention and management of CVD. PCSK9, a frequently targeted element in the treatment and prevention of CVD, can reduce cardiovascular risk by effectively lowering lipid levels even in the context of statin therapy. It also exhibits substantial potential in the diagnosis and treatment of familial hypercholesterolemia from genetic aspects. This bibliometric study aims to analyze and visualize the global trends and emerging hotspots of PCSK9 and CVD researches and provide researchers with new perspectives in further studies.MethodsThe data was obtained from the Web of Science Core Collection database. A total of 2,474 publications related to PCSK9 and CVD published between January 2006 and July 2023 were included. The VOSviewer was used to analyze most-cited references, co-authorship, co-citation, co-occurrence and generate a collaborative network map of authors, countries, and institutions. CiteSpace was used to analyze author and institution centroids, keyword bursts, and timeline graphs.ResultA total of 2,474 articles related to CVD and PCSK9 were included. The number of articles and citations show an increasing trend from year to year. Publications were mainly from the United States. The most active institution was Amgen Inc. Watts, Gerald F. was the most prolific author. Atherosclerosis was the most published journal. Literature co-citation and keyword co-occurrence revealed that early studies focused on the lipid-lowering effects of PCSK9 inhibitors in the context of statins therapy, long-term efficacy, adverse effects, LDLR, diagnosis and treatment of familial hypercholesterolemia. In recent years, myocardial ischemic protection, CRISPR-based editing, and new therapeutic strategies for arteriosclerotic cardiovascular disease have gotten wide attention. The protein convertase, inflammation, beta-polyacetate, and inclisiran may be the important future research directions.ConclusionThis study analyses the current status and global trends in the CVD and PCSK9 studies comprehensively, which may provide researchers and policymakers with new and comprehensive perspectives on in this field of research.