bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research of technological processing of semi-finished products in the manufacture of profile products from composite materials
Authors: Ihnatieva Viktoriia 
Published: June 2024

This article examines the process of technological processing of semi-finished product in the manufacture of rod profile products from fibrous composite materials, in particular - round. The purpose is to determine the theoretical value of the parameter which ensures the necessary impregnation of the winding layer during the final moulding of profile products.
It is mentioned that in order to ensure a defined structure and degree of filling during the production of rod profile products from spirally reinforced semi-finished products, they are compacted. Compaction can take place in one of two methods: by pressing in a spinneret, crimping with winding. The second method is used in the production of round cross-section rods. In this case, the spirally reinforced structural elements, which initially have a circular cross-sectional shape, deform and acquire an elliptical shape. At the same time, the degree of reinforcement filling of the central part of the structural element changes.
The volume of binder removed during deformation per unit time is presented as a function of the ellipse parameter.The displacement of the binder at steady-state mode of moulding is considered.Law of change of pressure gradient along the length of formed element before molding front is defined. The volume of binder removed during bundle formation per unit time is determined. Required molding pressure necessary to ensure a given degree of filling has been determined.
It is shown that it is possible to calculate the parameters of a deformed element that will ensure that the binder fills the space between the elements. An equation for determining the value of the parameter of the degree of crimping of an element, depending on the diameter of the used semi-finished product and the thickness of the winding layer is obtained. Data on critical values of a parameter of a degree of crimping of element, depending on diameter of a half-finished product and thickness of a layer of a winding is resulted. A method of determining the parameter of the degree of crimping of the element, which ensures the necessary impregnation of the winding layer during the forming of the profiled products, is proposed.
Mechanisms of Action of Toxins Released by Clostridium perfringens
Authors: Raza Ali , Sumaira Goshi  , Khan Ali , Mahmood Saher , Goshi Sumaira , Khalid Rmisha , Ijaz Minahil , Shaheen Muqaddas , Noor Aqsa , Bano Shaher , Asghar Sabahat , Afzal Tania , Akbar Zahra 
Published: June 2024

Clostridium perfringens, a rod-shaped anaerobe, is a Gram-positive bacterium that causes foodborne diseases. Its generation time is less than ten minutes and it can divide at 45°C. This aerotolerant bacterium has some toxigenic types (A, B, C, D, and E) that can cause diseases in human beings. Two of its newly discovered toxin types are F and G. Histotoxic, neurological, and intestinal illnesses in both people and animals are instigated by C. perfringens due to its wide range of protein toxins. Alpha or CPA, beta or CPB, epsilon or ETX, iota or ITX, and enterotoxin or CPE are the primary toxins that contribute toward diseases. CPA is the primary pathogenicity factor in gas poisoning in human beings, despite its limited and debatable involvement in animal illnesses. Necrotizing intestinal inflammation and enterotoxaemia in infants of various vertebrate species, particularly humans, are caused by CPB. Some other types cause illnesses in livestock. Necrotic and apoptotic traits are present in the molecular pathways of cell damage linked to C. perfringens toxins.
Prospects for Development of Forensic Methods for Investigation of Criminal Offenses Related to Raiding
Authors: Tiulieniev Serhii 
Published: June 2024

Formation and development of economic security of the State requires taking effective measures to counteract and minimize negative impact of criminal offenses that encroach on economic and social relations, legal activities of economic entities, rights of public administration employees, etc. Among the latter, those that demonstrate signs of raiding deserve close attention, i.e., related to the illegal takeover and seizure of property, assets of enterprises, institutions, organizations, corporate rights to them and other resources, encroachment on the rights of owners or authorized persons of entities management of various forms of ownership, etc. In this regard, the article purpose is defined as outlining prospects for construction of forensic methods of investigation of criminal offenses in which signs of raiding can be detected. In order to achieve the specified goal, a complex of general scientific, philosophical and special research methods was applied. According to performed research results, it was determined that in modern sense, a separate forensic investigation method (in a broad sense) should be understood as an integrated product of scientific knowledge in the field of law, formed on the basis of a generalization of investigative and judicial practice, which in its essence is a set of forensic recommendations, proven tactics methods of conducting investigative (search) and covert investigative (search) actions, methods and techniques of optimal and effective use of forensic techniques during pre-trial investigation developed in accordance with procedural requirements in order to optimize the model of conducting pre-trial investigation of a separate criminal offense, their groups, etc. Based on the generalization of certain elements of the criminal law and forensic characteristics of criminal offenses related to raiding, varieties of individual forensic methods of investigation have been determined, including interspecies, special, subspecies, species, etc.
Research, verification and evaluation of forensic expert conclusion: forensic veterinary aspect
Authors: Ivan Yatsenko 
Published: June 2024

The author aimed to outline the grounds and criteria, to single out methods and characterize procedural of research specifics, verification and evaluation of forensic veterinary expert conclusion . In order to achieve this goal, a set of interrelated research methods (dialectical, systemic-structural, systemic-functional, comparative-legal, formal logic (analysis, synthesis, deduction, induction, analogy), modeling, statistical) was applied. The grounds, criteria, methods and procedural specifics of the research, verification and assessment of forensic expert conclusion are considered. Attention is focused on forensic and veterinary aspect of this issue. It is claimed that during verification of forensic expert conclusion, it is necessary to assess its comprehensiveness, completeness and objectivity, as well as scientific validity, reliability, correctness, admissibility of using methods and techniques, means and methods of conducting expert research, as well as adequacy and relationship with other evidence collected within the framework of a criminal proceeding (case) with the aim of making a correct procedural decision (for evidence of factual data and circumstances proven by expert research). The criteria for completeness and reasonableness of the expert’s conclusion are proposed, as well as the algorithm for evaluating such a conclusion by the investigator, prosecutor, defense attorney, investigative judge, and court. The application of a set of these criteria to the assessment of a forensic expert’s opinion will guarantee the reliability of the verification and assessment of such conclusion, as well as create reliable conditions for making procedural decisions in legal proceedings.
WUWUNGAN SEBAGAI SUMBER IDE PENCIPTAAN LAMPU DUDUK KERAMIK
Authors: Yustana Prima 
Published: June 2024

Wuwungan which was originally functioned as part of the roof of a building will be transformed into another form, namely a sitting lamp. The transformation of the wuwungan into a sitting lamp raises several problem formulations related to how the process is made, how the technical completion of the innovation of roof decoration products into functional objects in the form of a sitting lamp, and whether the character of the sitting lamp inspired by the shape of the wuwungan can increase the atmosphere of beauty of a room.The purpose of this research itself is to find out how the difficulty level of making a sitting lamp is by taking ideas from wuwungan, knowing the process of creating functional works of art in detail step by step, knowing how to innovate sitting lamp products by deforming the real shape of the wuwungan, and creating works of art that are pleasing to the eye. innovative sourced from the strength of local genius.The expected benefits can be a guide for craftsmen or artists who will make innovative ceramic works, provide development in the form and type of product, in order to stimulate the creativity of artists and craftsmen in responding to traditional culture so that they can become innovative and interesting works. The research method used is the method of creating works of art by SP Gustami, namely three stages and six steps in the creation of craft works including exploration, design and embodiment. Keywords: Wuwungan, Ceramics, Sitting lamp
Karya Tari Dewaruci Sebagai Tari Sesaji Dalam Rangka Dies Natalis Isi Surakarta
Authors: Nuryanto Nuryanto 
Published: June 2024

The dance work Dewaruci is a new work inspired by Bima's attitude and character in wayang so that it is danced in the dashing male dance of the Surakarta style. The make-up and fashion design refer to the wayang orang characters in the Surakarta style. The purpose of the research entitled Dewaruci Dance Work is to describe the dashing Surakarta style dance used as offering dance at the Surakarta Indonesian Institute of the Arts (ISI) Anniversary ceremony in 2015. The research method of the Surakarta Style Dewaruci Dance Work is a type of qualitative research. Narrative data sources. Data analysis techniques use form and content. Data obtained from observation studies, interviews and documentation. The results of the research, the Dewaruci Dance Work is a themed group dance danced by seven dashing male dancers, as a symbol of the attitude and behavior of the academic community who have reached the age of 51. The gallant movements reflect valor, perseverance, honesty, firmness in studying and practice knowledge so that it is beneficial to society. The movement begins with offerings accompanied by Yogyan Pelog Nem Sieve.Keywords: dashing, dance, offerings, anniversary
PERBANDINGAN SAJIAN MAKANAN DALAM UPACARA BESAR SUKU TENGGER: ANALISIS NILAI BUDAYA
Authors: Lestari Dwi Indah 
Published: June 2024

The Tengger tribe is one of the majority Hindus, the sect they profess is mostly Mahayana Hinduism, but not a few are also Muslims. The spread of the Tengger tribe community has expanded not only in the Lumajang argosari area, but also to the Malang area. The Tengger tribe is the tribe best known for the least criminal acts in Indonesia, not only that the Tengger tribe is famous for a tribe that has a very strong tolerance value both in religious life and in community life. This research uses research methods of literature studies or literature reviews, data taken from various references ranging from articles, websites, journals, theses and theses. From the various data that the author has collected, the author can provide conclusions about the differences in presentation in each traditional ceremony. Because the Tengger people beieve that with the dishes they give every time there is a major religious event they do, they always have special dishes as a thanksgiving, the Tengger tribe people believe that by giving symbolic food offerings to the spirits that have left, making them more docile and not disturbing living creatures. The dishes given do not have to be luxurious food but complete according to the provisions of each traditional event. Keywords: tolerance, serving, custom
Ideological motivation and economic policy on examples of high-ranking bureaucracy’s actions (part 1)
Authors: Selishchev Nikolay 
Published: June 2024

It is considered interdependence of ideological motivation and pursuing economic policy, role of high-ranking bureaucracy in the decision-making process, significance of mentality and of historical-juridical heritage on Russia’s, Cuba’s, Venezuela’s, Serb Republic in Bosnia and Herzegovina’s examples. It is analyzed the deliberate renunciation of mercantilist and protectionist traditions in modern France and Germany, genuine motives of Euro-commission’s strategy, role of so called «the economic establishment» in dismissals of the British Prime-Ministers without to hold an general election.
How effective are prescriptive governance tools? Results from the application of AIFA notes
Authors: Moretti Giaele , Dal Canto Benedetta , Attanasio Francesco , Martelli Alma , Ferrè Francesca 
Published: June 2024

Introduction: Prescription appropriateness is crucial for healthcare, balancing scientific evidence, optimal benefit/risk ratios and cost-effectiveness in alignment with the National Health System (NHS) sustainability. In Italy, various governance tools, including Notes AIFA, regulate drug reimbursements. This research aims to evaluate the impact of the introduction of Notes AIFA in curbing consumption and expenditures and assessing their lasting effects. We evaluate the effect generated by the Notes in terms of prescriptive appropriateness by assessing their effect on reducing overprescribing phenomena for drugs covered by the Notes. Note 96, focused on the prevention and treatment of vitamin D deficiency in adults, is used as a case study to evaluate the short- and long-term effectiveness of these tools on prescribing behaviors.
Methods: Using a quasi-experimental approach, administrative data on pharmaceutical consumption in Tuscany over 60 months (22 pre- and 38 post-Note) were analyzed. Interrupted Time Series (ITS) analysis at regional, and local health authorities (LHAs), and primary care group practices (AFTs) was performed.
Results and conclusions: The ITS analysis showed an immediate reduction in consumption rates and spending post-Note 96. This real-world study highlights short-term effectiveness and suggests a positive long-term impact, despite recognizing a physiological increase in consumption at the regional level. The findings emphasize that ongoing continual monitoring of its effectiveness is imperative to promptly identify failures in implementation and mitigate the risk of consumption escalation, potentially reverting to pre-intervention levels.
Risk factors for poor treatment outcomes among opioid-dependent clients taking methadone in Mombasa, Kenya
Authors: Mwanyalu Nassoro , Nunga Maria , Mwanyamawi Raphael , Abdallah Saade , Owiny Maurice 
Published: June 2024

Background: The Methadone Maintenance Treatment (MMT) program has been proven to be beneficial in reducing illicit opioid use, increasing access to and retention of HIV treatment and other therapies, and reducing HIV transmission, and other drug-related morbidities and mortalities. However, determinants of treatment retention and outcomes for opioid-dependent persons accessing MMT in Kenya are limited. We sought to identify factors contributing to poor treatment outcomes among opioid-dependent persons enrolled in the Mombasa MMT program, between 2017 and 2019.Method: We conducted a retrospective records review for opioid-dependent persons receiving Methadone treatment in the Kisauni MAT clinic enrolled during 2017–2019. We defined poor clinical or health-related treatment outcome as any client Lost-To-Follow-Up (LTFU), turned HIV or Viral hepatitis positive, and/or missed two or more antiretroviral therapy (ART) appointments intake during MMT. Variables abstracted from clinical and pharmacological MMT service delivery tools included socio-demographic characteristics, clinical history, risk factors, and MMT outcomes. Data were analyzed using Epi Info7. We calculated Prevalence Odds Ratios (POR) and 95% Confidence Intervals (CI) to identify factors associated with adverse health outcomes.Results: Of the total 443 eligible records, the mean age was 37 years (SD ± 7.2) and males comprised 90.7%. The majority of females clients, 79.1% (34/43), were aged ≤35 years, 7.0% (3/43) had no education, 32.6% (14/43) were employed, 39.5% (17/43) were HIV positive and 18.6% (8/43) were HCV-positive. Overall, adverse treatment outcomes were at 27.5% (122/443), namely: LTFU at 22.8% (101/443), new HIV cases at 1.0% (4/391), HCV at 1.2% (5/405), and Hepatitis B Virus (HBV) at 1.2% (5/411), and 1.1% (5/443) died. Of HIV-infected clients linked to Comprehensive Care Clinic (CCC), 3.6% (2/56) defaulted from ART, and 25% (2/8) had detectable Viral Load of those retested. Lack of formal education (POR: 2.7, 95% CI: 1.3–5.7), unemployment (POR: 2.4, 95% CI: 1.4–4.0), and being a Non-Injector (POR: 1.7, 95% CI: 1.0–2.9) were negatively associated with treatment retention.Conclusion: Females were younger, and more educated with higher HIV and HCV prevalence. Being a Non-injector, unemployment, and lack of formal education may increase the likelihood of poor treatment outcomes among MMT clients. Closer monitoring of MMT clients with these characteristics is recommended with the integration of CCC into MMT services.
Long-term sensorimotor changes after a sciatic nerve block with bupivacaine and liposomal bupivacaine in a high-fat diet/low-dose streptozotocin rodent model of diabetes
Authors: Byram Susanna C. , Lotesto Krista M. , Volyanyuk Michael , Exline Jacob E. , Sager Elizabeth A. , Foecking Eileen M. 
Published: June 2024

IntroductionIt is unclear whether patients with diabetes are more susceptible to nerve toxicity of local anesthetics or whether nerve blocks can accelerate the progression of diabetic peripheral neuropathy. Bupivacaine is one of the most widely used local anesthetics for regional anesthesia despite many pre-clinical studies demonstrating neurotoxicity. Herein, we report the long-term functional consequences of sciatic nerve block with bupivacaine and liposomal bupivacaine (Exparel®) in an animal model of diabetes.MethodsMale Sprague Dawley rats were subject to standard chow/vehicle or high-fat diet/low-dose streptozotocin to induce a diabetic phenotype. Animals were then subdivided into groups that received repeated sciatic nerve blocks of saline, bupivacaine, or liposomal bupivacaine. Mechanical allodynia and thermal hyperalgesia were assessed prior to and 12 weeks following nerve blocks utilizing the von Frey and Hargreaves tests, respectively. Exploratory and locomotor activity were assessed with open field testing, and nerve conduction velocity testing was conducted prior to the termination of the study at 28 weeks.ResultsAnimals in the diabetic group developed sustained hyperglycemia &gt;200 mg/dl and signs of peripheral neuropathy six weeks after treatment with streptozotocin, which persisted until the end of the study. Twelve weeks after a repeated sciatic nerve block with saline, bupivacaine, or liposomal bupivacaine, results indicate significant interaction effects of the disease group (control vs. diabetic) and local anesthetic treatment. Overall, diabetic status resulted in worse sensorimotor function compared to control animals. Treatment with perineural bupivacaine resulted in worse sensorimotor functions in both control and diabetic animals. Furthermore, bupivacaine treatment in diabetic animals with pre-existing neuropathy exacerbated sensorimotor function in some measures. In contrast, liposomal bupivacaine did not appear to cause any negative effects on functional outcomes for control or diabetic animals.ConclusionOur data indicate that bupivacaine, and not liposomal bupivacaine, causes long-term changes in tactile allodynia, thermal hyperalgesia, locomotor behaviors, and nerve conduction velocity in control as well as a high-fat diet/low-dose streptozotocin rodent model of diabetes. These results highlight the necessity to investigate safe peripheral nerve block strategies to preserve long-term functional independence in patients with or at risk for diabetic peripheral neuropathy.
Unveiling interactions between intervertebral disc morphologies and mechanical behavior through personalized finite element modeling
Authors: Muñoz-Moya Estefano , Rasouligandomani Morteza , Ruiz Wills Carlos , Chemorion Francis Kiptengwer , Piella Gemma , Noailly Jérôme 
Published: June 2024

Introduction: Intervertebral Disc (IVD) Degeneration (IDD) is a significant health concern, potentially influenced by mechanotransduction. However, the relationship between the IVD phenotypes and mechanical behavior has not been thoroughly explored in local morphologies where IDD originates. This work unveils the interplays among morphological and mechanical features potentially relevant to IDD through Abaqus UMAT simulations.Methods: A groundbreaking automated method is introduced to transform a calibrated, structured IVD finite element (FE) model into 169 patient-personalized (PP) models through a mesh morphing process. Our approach accurately replicates the real shapes of the patient's Annulus Fibrosus (AF) and Nucleus Pulposus (NP) while maintaining the same topology for all models. Using segmented magnetic resonance images from the former project MySpine, 169 models with structured hexahedral meshes were created employing the Bayesian Coherent Point Drift++ technique, generating a unique cohort of PP FE models under the Disc4All initiative. Machine learning methods, including Linear Regression, Support Vector Regression, and eXtreme Gradient Boosting Regression, were used to explore correlations between IVD morphology and mechanics.Results: We achieved PP models with AF and NP similarity scores of 92.06\% and 92.10\% compared to the segmented images. The models maintained good quality and integrity of the mesh. The cartilage endplate (CEP) shape was represented at the IVD-vertebra interfaces, ensuring personalized meshes. Validation of the constitutive model against literature data showed a minor relative error of 5.20%.Discussion: Analysis revealed the influential impact of local morphologies on indirect mechanotransduction responses, highlighting the roles of heights, sagittal areas, and volumes. While the maximum principal stress was influenced by morphologies such as heights, the disc's ellipticity influenced the minimum principal stress. Results suggest the CEPs are not influenced by their local morphologies but by those of the AF and NP. The generated free-access repository of individual disc characteristics is anticipated to be a valuable resource for the scientific community with a broad application spectrum.
Impact of ionizing radiation on cell-ECM mechanical crosstalk in breast cancer
Authors: Mottareale Rocco , Frascogna Crescenzo , La Verde Giuseppe , Arrichiello Cecilia , Muto Paolo , Netti Paolo A. , Fusco Sabato , Panzetta Valeria , Pugliese Mariagabriella 
Published: June 2024

The stiffness of the extracellular matrix plays a crucial role in cell motility and spreading, influencing cell morphology through cytoskeleton organization and transmembrane proteins’ expression. In this context, mechanical characterization of both cells and the extracellular matrix gains prominence for enhanced diagnostics and clinical decision-making. Here, we investigate the combined effect of mechanotransduction and ionizing radiations on altering cells’ mechanical properties, analysing mammary cell lines (MCF10A and MDA-MB-231) after X-ray radiotherapy (2 and 10 Gy). We found that ionizing radiations sensitively affect adenocarcinoma cells cultured on substrates mimicking cancerous tissue stiffness (15 kPa), inducing an increased structuration of paxillin-rich focal adhesions and cytoskeleton: this process translates in the augmentation of tension at the actin filaments level, causing cellular stiffness and consequently affecting cytoplasmatic/nuclear morphologies. Deeper exploration of the intricate interplay between mechanical factors and radiation should provide novel strategies to orient clinical outcomes.