bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and safety of belantamab mafodotin in patients with relapsed or refractory multiple myeloma in real‐world setting: The ALFA study
Authors: Roussel Murielle , Texier Nathalie , Nael Virginie , Bitetti Jacopo , Paka Prani , Kerbouche Naima , Sail Lynda , Colin Xavier , Leleu Xavier 
Published: May 2024

AbstractObjectivesThe aim of this noninterventional, retrospective ALFA study was to describe belantamab mafodotin effectiveness and safety in patients with relapsed/refractory multiple myeloma in a real‐world setting in France.MethodsResponse rate, progression‐free survival (PFS), overall survival (OS), and safety were assessed.ResultsAmong the 184 patients initiating belantamab mafodotin treatment, the overall response rate was 32.7% (≥very good partial response [VGPR] 20.4%, partial response [PR] 12.3%). The median PFS (mPFS) was 2.4 months (95% confidence interval [CI]: 1.9, 3.3), and median OS (mOS) was 8.8 months (95% CI: 6.3, 11.6). According to best response, mPFS was 20.6 months (95% CI: 12.1, not reached [NR]) in patients with ≥VGPR and 7.1 months (95% CI: 4.6, 9.4) in patients with PR; mOS was NR in patients with ≥VGPR and 17.5 months (95% CI: 7.7, NR) in patients with PR. For both OS and PFS, no differences were found in subgroups of interest. The adverse events (AEs) reported in 159 patients (86.4%) were mostly ocular AEs.ConclusionsALFA, the largest real‐world cohort conducted so far, confirms the results of belantamab mafodotin as reported in the DREAMM‐2 clinical trial. The clinical benefit is significant as long as the patient is a responder.
Reorganization of dopamine circuitry in the anterior corpus callosum between early adolescence and adulthood in the mouse
Authors: Caldwell Megan , Mendoza Josue Criollo , Jiang Xin Yan Zhu , Alarcon Colin , Ayo‐Jibunoh Vanessa , Louis Shelby , Maronna Daniel , Darwish Rania , Tomaio Jaquelyn , Mingote Susana , Yetnikoff Leora 
Published: May 2024

AbstractThe maturation of forebrain dopamine circuitry occurs over multiple developmental periods, extending from early postnatal life until adulthood, with the precise timing of maturation defined by the target region. We recently demonstrated in the adult mouse brain that axon terminals arising from midbrain dopamine neurons innervate the anterior corpus callosum and that oligodendrocyte lineage cells in this white matter tract express dopamine receptor transcripts. Whether corpus callosal dopamine circuitry undergoes maturational changes between early adolescence and adulthood is unknown but may be relevant to understanding the dramatic micro‐ and macro‐anatomical changes that occur in the corpus callosum of multiple species during early adolescence, including in the degree of myelination. Using quantitative neuroanatomy, we show that dopamine innervation in the forceps minor, but not the rostral genu, of the corpus callosum, is greater during early adolescence (P21) compared to adulthood (>P90) in wild‐type mice. We further demonstrate with RNAscope that, as in the adult, Drd1 and Drd2 transcripts are expressed at higher levels in oligodendrocyte precursor cells (OPCs) and decline as these cells differentiate into oligodendrocytes. In addition, the number of OPCs that express Drd1 transcripts during early adolescence is double the number of those expressing the transcript during early adulthood. These data further implicate dopamine in axon myelination and myelin regulation. Moreover, because developmental (activity‐independent) myelination peaks during early adolescence, with experience‐dependent (activity‐dependent) myelination greatest during early adulthood, our data suggest that potential roles of dopamine on callosal myelination shift between early adolescence and adulthood, from a developmental role to an experience‐dependent role.
Effects of rTMS to primary motor cortex and cerebellum on balance control in healthy adults
Authors: Parikh Vyoma , Medley Ann , Goh Hui‐Ting 
Published: May 2024

AbstractBoth the primary motor cortex (M1) and the cerebellum are crucial for postural stability and deemed as potential targets for non‐invasive brain stimulation (NIBS) to enhance balance performance. However, the optimal target remains unknown. The purpose of this study was to compare the role of M1 and the cerebellum in modulating balance performance in young healthy adults using facilitatory 5 Hz repetitive transcranial magnetic stimulation (rTMS). Twenty‐one healthy young adults (mean age = 27.95 ± 1.15 years) received a single session of 5 Hz rTMS on M1 and the cerebellum in a cross‐over order with a 7‐day washout period between the two sessions. Three balance assessments were performed on the Biodex Balance system SD: Limits of Stability (LOS), modified Clinical Test of Sensory Interaction on Balance (mCTSIB), and Balance Error Scoring System (BESS). No significant effect of rTMS was found on the LOS. The effect of rTMS on the mCTSIB was mediated by stimulation target, proprioception, and vision (p = .003, ηp2 = 0.37). Cerebellar rTMS improved the mCTSIB sway index under eyes closed‐foam surface condition (p = .02), whereas M1 rTMS did not result in improvement on the mCTSIB. The effect of rTMS on the BESS was mediated by stimulation target, posture, and proprioception (p = .049, ηp2 = 0.14). Cerebellar rTMS enhanced reactive balance performance during most sensory deprived conditions.
Depth versus surface: A critical review of subdural and depth electrodes in intracranial electroencephalographic studies
Authors: Wu Shasha , Issa Naoum P. , Rose Sandra L. , Haider Hiba A. , Nordli Douglas R. , Towle Vernon L. , Warnke Peter C. , Tao James X. 
Published: May 2024

AbstractIntracranial electroencephalographic (IEEG) recording, using subdural electrodes (SDEs) and stereoelectroencephalography (SEEG), plays a pivotal role in localizing the epileptogenic zone (EZ). SDEs, employed for superficial cortical seizure foci localization, provide information on two‐dimensional seizure onset and propagation. In contrast, SEEG, with its three‐dimensional sampling, allows exploration of deep brain structures, sulcal folds, and bihemispheric networks. SEEG offers the advantages of fewer complications, better tolerability, and coverage of sulci. Although both modalities allow electrical stimulation, SDE mapping can tessellate cortical gyri, providing the opportunity for a tailored resection. With SEEG, both superficial gyri and deep sulci can be stimulated, and there is a lower risk of afterdischarges and stimulation‐induced seizures. Most systematic reviews and meta‐analyses have addressed the comparative effectiveness of SDEs and SEEG in localizing the EZ and achieving seizure freedom, although discrepancies persist in the literature. The combination of SDEs and SEEG could potentially overcome the limitations inherent to each technique individually, better delineating seizure foci. This review describes the strengths and limitations of SDE and SEEG recordings, highlighting their unique indications in seizure localization, as evidenced by recent publications. Addressing controversies in the perceived usefulness of the two techniques offers insights that can aid in selecting the most suitable IEEG in clinical practice.
Influence mechanism of Ni2O3 doping on leakage current of SnO2 varistor ceramics
Authors: Sun Fei , Zhao Hongfeng , Miao Kui 
Published: May 2024

AbstractThe doping of Ni2O3 has significantly enhanced the electrical properties and density of SnO2–Co3O4–Cr2O3–Nb2O5 varistor ceramics. The leakage current density is reduced to 4.73 µA/cm2, the nonlinear coefficient is 37, and the voltage gradient is 549 V/mm. The undoped varistor ceramics exhibited a considerably higher leakage current of 48.04 µA/cm2. The performance improvement comes from alterations in grain boundary parameters. The doping of an appropriate amount of Ni improves the grain boundary barrier of SnO2 varistor ceramics and makes samples obtain higher grain boundary resistance, which hinders the leakage current path and results in excellent nonohmic characteristics. The stable grain boundary barrier structure dominated by Ni enables the sample to obtain stable power loss performance under long‐term direct current (DC) bias.
Mechanical properties and thermal shock resistance of TiB2‒B4C composite ceramic tool materials at microscopic scale
Authors: Wang Dong , Ding Zhengwei , Zhang Chao , Zhao Jianwen , Lei Yuyang , Zhang Geng , Zheng Guang 
Published: May 2024

AbstractA finite model incorporating microstructure was developed to investigate the thermal shock resistance of TiB2‒B4C composite ceramic cutting tool materials. Numerical simulations were conducted to analyze changes in the transient temperature field and thermal stress field during the thermal shock process. TiB2‒B4C composite ceramic tool materials were fabricated using discharge plasma sintering technology. With different B4C contents, different sintering temperatures and holding times as study variables, optimization of the sintering process parameters and ceramic material components was achieved through testing the mechanical and microscopic morphology of the ceramics. Thermal shock water quenching experiments were performed, and the strength‐decay method was employed to assess the thermal shock resistance of TiB2‒B4C ceramics. The findings indicate that the optimal sintering conditions are temperature of 1700°C and holding time of 5 min. The TiB2‒B4C ceramic material containing 20 vol% B4C exhibits superior comprehensive mechanical properties and thermal shock resistance, and its relative density, fracture toughness, hardness, and flexural strength were 99.3%, 6.8 MPa m1/2, 22.8 GPa, and 598 MPa, respectively. The critical thermal shock temperature difference falls within the range of 400°C‒500°C.
Nurse burnout: It is an urgent issue affecting the profession
Authors: Ginaldi Lia , Azzellino Gianluca , D'Olimpio Alessia , Grilli Vanessa , De Martinis Massimo 
Published: May 2024

AbstractThe nursing profession is going through a profound crisis, and staff burnout is a frequent and worrying aspect. As suggested by Xie et al., there are good prospects for undertaking improvement paths. We agree with the authors' suggestions and add further ideas for a change of direction and the renewal of the nursing profession.
Combining convolution neural networks with long‐short term memory layers to predict Parkinson's disease progression
Authors: Frasca Maria , Torre Davide La , Pravettoni Gabriella , Cutica Ilaria 
Published: May 2024

AbstractParkinson's disease (PD) is a neurological condition that occurs in nearly 1% of the world's population. The disease is manifested by a sharp drop in dopamine production, resulting from the death of the related producing cells in an area of the midbrain called the substantia nigra. Early diagnosis and accurate staging of the disease are essential to apply the appropriate therapeutic approaches to slow cognitive and motor decline. At present, there is not a singular blood test or biomarker accessible for diagnosing PD or monitoring the progression of its symptoms. Clinical professionals identify the disease by assessing the symptoms, which, however, may vary from case to case, as well as their progression speed. Magnetic resonance imaging (MRIs) have been used for the past three decades to diagnose and distinguish between PD and other neurological conditions.However, to the best of our knowledge, no neural network models have been designed to identify the disease stage. This paper aims to fill this gap. Using the “Parkinson's Progression Markers Initiative” dataset, which reports the patient's MRI and an indication of the disease stage, we developed a model to identify the level of progression. The images and the associated scores were used for training and assessing different deep learning models. Our analysis distinguished four distinct disease progression levels based on a standard scale (Hoehn and Yah scale). The final architecture consists of the cascading of a 3D‐CNN network, adopted to reduce and extract the spatial characteristics of the MRI for efficient training of the successive LSTM layers, aiming at modeling the temporal dependencies among the data. Before training the model, the patient's MRI is preprocessed to correct acquisition errors by applying image registration techniques, to extract irrelevant content from the image, such as nonbrain tissue (e.g., skull, neck, fat). We also adopted template‐based data augmentation techniques to obtain a balanced dataset about progression classes. Our results show that the proposed 3D‐CNN + LSTM model achieves state‐of‐the‐art results by classifying the elements with 91.90 as macro averaged OVR AUC on four classes.
Spillover effects of organizational support for patient and workplace safety on safety outcomes: The mediating role of safety compliance
Authors: Seo Ja Kyung , Lee Seung Eun 
Published: May 2024

AbstractAim(s)To investigate spillover effects of organizational support for patient and workplace safety on safety outcomes and to examine the mediating role of safety compliance in these relationships.DesignA cross‐sectional, correlational survey design.MethodsThis study analysed data from 1255 nurses in 34 Korean hospitals. A structured questionnaire was used including items from the Hospital Survey on Patient Safety Culture and Safety Compliance scales. Data were collected between February and June 2022. We employed structural equation modelling (SEM) for analysis with a significance level set at 0.05.ResultsOrganizational support for patient and workplace safety showed direct impacts on patient and workplace safety outcomes. Findings supported our hypotheses regarding spillover effects, as organizational support for patient safety was related to enhanced workplace safety and organizational support for workplace safety was associated with improved patient safety. SEM analysis showed safety compliance's mediating role. When the distribution of serial indirect effects was examined, three out of eight indirect pathways were statistically significant.ConclusionImproving organizational support for patient safety can lead to better workplace safety outcome, and enhancing support for workplace safety can result in better patient safety outcome. Given this mutually beneficial relationship, healthcare organizations should simultaneously promote safety in both areas rather than focusing on just one.Implications for the Profession and/or Patient CareStudy results highlight the need to recognize the interconnected nature of patient and workplace safety in order to achieve better overall safety outcomes.ImpactThis study shows that organizational safety efforts for patients and workers are interconnected and mutually beneficial. The study's results have both theoretical and practical implications in demonstrating that organizational support for both patient and workplace safety plays a strong role in promoting nurses' safety compliance and improving overall safety outcomes.Reporting MethodSTROBE checklist.Patient ContributionNo patient or public contribution.
3D printed kombucha biomaterial as a tissue scaffold and L929 cell cytotoxicity assay
Authors: Bağlan İlkyaz , Yanbakan Edagül , Tuncel Tuğba , Koçak Sezgin Ayşe , Bozoğlan Emirhan , Berikten Derya , Kar Fatih 
Published: May 2024

AbstractTissue engineering includes the construction of tissue‐organ scaffold. The advantage of three‐dimensional scaffolds over two‐dimensional scaffolds is that they provide homeostasis for a longer time. The microbial community in Symbiotic culture of bacteria and yeast (SCOBY) can be a source for kombucha (kombu tea) production. In this study, it was aimed to investigate the usage of SCOBY, which produces bacterial cellulose, as a biomaterial and 3D scaffold material. 3D printable biomaterial was obtained by partial hydrolysis of oolong tea and black tea kombucha biofilms. In order to investigate the usage of 3D kombucha biomaterial as a tissue scaffold, “L929 cell line 3D cell culture” was created and cell viability was tested in the biomaterial. At the end of the 21st day, black tea showed 51% and oolong tea 73% viability. The cytotoxicity of the materials prepared by lyophilizing oolong and black tea kombucha beverages in fibroblast cell culture was determined. Black tea IC50 value: 7.53 mg, oolong tea IC50 value is found as 6.05 mg. Fibroblast viability in 3D biomaterial + lyophilized oolong and black tea kombucha beverages, which were created using the amounts determined to these values, were investigated by cell culture Fibroblasts in lyophilized and 3D biomaterial showed viability of 58% in black tea and 78% in oolong tea at the end of the 7th day. In SEM analysis, it was concluded that fibroblast cells created adhesion to the biomaterial. 3D biomaterial from kombucha mushroom culture can be used as tissue scaffold and biomaterial.
Validation of MELD 3.0 in patients with alcoholic liver cirrhosis using prospective KACLiF cohort
Authors: Lim Jihye , Kim Jung Hee , Kim Sung‐Eun , Han Seul Ki , Kim Tae Hyung , Yim Hyung Joon , Jung Young Kul , Song Do Seon , Yoon Eileen L. , Kim Hee Yeon , Kang Seong Hee , Chang Young , Yoo Jeong‐Ju , Lee Sung Won , Park Jung Gil , Park Ji Won , Jeong Soung Won , Suk Ki Tae , Kim Moon Young , Kim Sang Gyune , Kim Won , Jang Jae Young , Yang Jin Mo , Kim Dong Joon ,   The Korean Acute on‐Chronic Liver Failure (KACLiF) Study Group
Published: May 2024

AbstractBackground and AimThe Model for End‐Stage Liver Disease (MELD) is a reliable prognostic tool for short‐term outcome prediction in patients with end‐stage liver disease. MELD 3.0 was introduced to enhance the predictive accuracy. This study assessed the performance of MELD 3.0, in comparison to MELD and MELD‐Na, in patients with alcoholic liver cirrhosis.MethodsThis multicenter prospective cohort study comprised patients with alcoholic cirrhosis admitted for acute deterioration of liver function in the Republic of Korea between 2015 and 2019. This study compared the predictive abilities of MELD, MELD‐Na, and MELD 3.0, for 30‐day and 90‐day outcomes, specifically death or liver transplantation, and explored the factors influencing these outcomes.ResultsA total of 1096 patients were included in the study, with a mean age of 53.3 ± 10.4 years, and 82.0% were male. The mean scores for MELD, MELD‐Na, and MELD 3.0 at the time of admission were 18.7 ± 7.2, 20.6 ± 7.7, and 21.0 ± 7.8, respectively. At 30 and 90 days, 7.2% and 14.1% of patients experienced mortality or liver transplantation. The areas under the receiver operating characteristic curves for MELD, MELD‐Na, and MELD 3.0 at 30 days were 0.823, 0.820, and 0.828; and at 90 days were 0.765, 0.772, and 0.776, respectively. Factors associated with the 90‐day outcome included concomitant chronic viral hepatitis, prolonged prothrombin time, elevated levels of aspartate transaminase, bilirubin, and creatinine, and low albumin levels.ConclusionMELD 3.0 demonstrated improved performance compared to previous models, although the differences were not statistically significant.
A geriatric game to strengthen older adult healthcare delivery and outcomes
Authors: Jurivich Donald A. , Van Eck Richard N. , Wood Joseph R. , Snustad Dakota , Holloway Jeremy , Langendoen David , Hughes Marc , Galynker Benjamin , Brewster Scott , Manocha Gunjan D. 
Published: May 2024

AbstractBackgroundSerious games enhance learner engagement and knowledge, yet few medical education games target older adults' healthcare. Addressing this gap, we developed Geri‐POP (Geriatrics Population Health), focusing on the Age‐Friendly Health System (AFHS) framework and Geriatric 4Ms.MethodsGeri‐POP, a healthcare game is aimed at educating health profession learners about the AFHS framework. Geri‐POP employs plan–do–study–act cycles of rapid improvement to apply AFHS principles and explore evidence‐based geriatric practices within the game environment while garnering points for insight, trust and outcomes. Faculty and medical students were surveyed for feedback on an alpha version of Geri‐POP.ResultsPlayers manage patient panels across three age groups (65–74, 75–84, and 85 years and older) while engaging in plan–do–study–act (PDSA) cycles, applying Geriatric 4Ms (What Matters, Medications, Mentation, and Mobility), and refining strategies based on resource utilization, health outcomes, and real‐time feedback. Alpha testing of the game received mixed perceptions on graphics, with faculty endorsing the game for training and integration into the curriculum, while students prioritize academic commitments. Suggestions include enhancing graphics and refining dialogue for a more professional tone.ConclusionsGeri‐POP demonstrates the potential of gamifying older adult population health and quality improvement around AFHS. Feedback on a prototype game revealed different attitudes between faculty and students, thus emphasizing the importance of game development as an iterative process that accounts for educator and learner‐centric needs. A future consideration is whether the game informs user's clinical practices and changes healthcare outcomes for older adults.
Initiative to deprescribe high‐risk drugs for older adults presenting to the emergency department after falls
Authors: Selman Katherine , Roberts Ellen , Niznik Joshua , Anton Greta , Kelley Casey , Northam Kalynn , Teresi Brittni B. , Casey Martin F. , Busby‐Whitehead Jan , Davenport Kathleen 
Published: May 2024

AbstractBackgroundOver 35 million falls occur in older adults annually and are associated with increased emergency department (ED) revisits and 1‐year mortality. Despite associations between medications and falls, the prevalence of fall risk‐increasing drugs remains high. Our objective was to implement an ED‐based medication reconciliation for patients presenting after falls and determine whether an intervention targeting high‐risk medications was related to decreased future falls.MethodsThis was an observational prospective cohort study at a single site in the United States. Adults 65 years and older presenting to the ED after falls had a pharmacist review their medicines. Pharmacists made recommendations to taper, stop, or discuss medications with the primary clinician. At 3, 6, and 12 months, we recorded the number of fall‐related return ED visits and determined if recommended medication changes had been implemented. We compared the rate of return visits of patients who had followed the medication change recommendations and those who received recommendations but had no change in their medications using chi‐square tests.ResultsA total of 577 patients (mean age 81 years, 63.6% female) were enrolled of 1509 potentially eligible patients. High‐risk medications were identified in 310 patients (53.7%) who received medication recommendations. High‐risk medications were associated with repeat fall‐related visits at 12 months (risk difference 8.1% [95% confidence interval 0.97–15.0]). A total of 134 (43%) patients on high‐risk medications had evidence of medication modification. At 12 months, there was no statistically significant difference in return fall visits between patients who had modifications to medications compared with those who had not implemented changes (p = 0.551).ConclusionsOur findings identified opportunities for medication optimization in over half of emergency visits for falls and demonstrated that medication counseling in the ED is feasible. However, evaluation of the effect on future falls was limited.
On the Welfare Costs of Perceptions Biases
Authors: MONTAG HUGH 
Published: May 2024

AbstractAre households harmed by inaccurate inflation beliefs? This paper analyzes two established inflation perceptions biases and evaluates their welfare effects. Using French survey data I study the frequency bias, where households overweight goods that they purchase frequently, and the level bias, where households consistently overestimate current inflation. To evaluate the associated welfare losses, I incorporate biased inflation perceptions into a model with a nominal bond subject to inflation risk. Only the level bias significantly reduces welfare and asset accumulation. Removing the perception bias reduces the welfare loss, suggesting that inaccurate perceptions can harm households beyond affecting expectations.