bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Second-Opinion Delivery for Oncology Patients
Authors: Shah Aadit P. , Shi Siyu , Sun Thomas Y. , Patel Manali I. , Shah Sumit A. 
Published: February 2025

PURPOSE
Patients with cancer face increasing difficulty securing access to timely, quality oncologic care. A virtual consultation program at a tertiary academic center could eliminate physical barriers while providing treatment recommendations that could be executed locally.

METHODS

We evaluated an
Online Second Opinions Program
to increase access to expert care via a cloud-based platform through Included Health. This program was open to any patient globally who had a local treating physician. Patient records were compiled and sent to a disease expert at Stanford Healthcare. A report detailing an assessment and treatment recommendation was then returned within 3 days. We analyzed the characteristics of the patient base and the frequency with which treatment change was recommended.

RESULTS
Between November 2018 and August 2020, 657 patients participated in the program. The majority of patients were female (58.4%) with a mean age of 60 years. A majority lived out-of-state (62%, with 24.7% of total patients from outside the United States) and had advanced disease (77.2% diagnosed at stage III or IV). Breast cancer was the most common diagnosis (24.7%). Physicians providing the virtual service were primarily medical oncologists (67.6%) and reported to have recommended a treatment change in more than half of the cases reviewed (53.8%). A treatment change was most often recommended for patients with stage II disease (64%), and least often for stage I and III disease (both 45%).

CONCLUSION
To our knowledge, this is one of the first studies to describe patients who use virtual second-opinion programs for oncology, showing that more than half of the patients were recommended to have a treatment change. Although patients most often had advanced disease, those with stage II disease most often received a treatment change recommendation.
Entanglement signatures of the small world transition in Heisenberg type models across network topologies
Authors: Solanki Payal D. , Ramkarthik M. S. 
Published: February 2025

Abstract
This paper, investigates the Heisenberg model across diverse network topologies, and studying the variation of entanglement measures across these network topologies. Various network types are introduced along with their properties. An algorithm for generating networks using the Watts-Strogatz small world model is presented,focusing on the transition from regular to random networks via the small world regime. The objective is to explore the entanglement landscape of the Heisenberg model across these network conﬁgurations, using extensive numerics. Insights into entanglement behaviour using graph theoretic properties such as local average clustering coeﬃcient and the number of edge cuts during bipartitioning are provided. This opens up ways to analyze such complicated network topologies using entanglement.&#xD;
Jansen’s disease: bone abnormalities beyond chondrodysplasia
Authors: Pereira Renata C , Delany Anne M , Reyes Monica , Gales Barbara , Jüppner Harald , Salusky Isidro B 
Published: February 2025

Abstract

Objective
This study aimed to assess changes in bone microarchitecture, bone formation and bone protein expression in two pediatric patients with Jansen metaphyseal chondrodysplasia (JMC), harboring the H223R-PTHR1 mutation.

Methods
Bone histomorphometry, immunohistochemistry and histologic analyses were conducted on iliac crest biopsy samples from two male siblings affected by JMC (ages 6 and 8 years) and 9 healthy control males of similar age, with normal kidney function.

Results
Both JMC patients displayed irregular bone architecture, increased osteoid, and a prolonged osteoid maturation process. While trabecular volume remained normal, immunohistochemical analysis demonstrated increased in PTH1R expression in both osteoblasts and fibroblastic cells on the bone surface. Cortical bone displayed areas of intense osteoclast activity and scattered marrow fibrosis. Remarkably, osteocytes in JMC patient samples had osteoid buildup within their lacunae and canaliculi that were both shorter and less abundant. DMP1 immunohistochemistry highlighted the abnormal canalicular network in patients. FGF23 staining in osteocytes was enhanced while sclerostin was diminished.

Conclusion
The H223R-PTH1R mutation in JMC patients leads to bone structural irregularities, hypomineralization, abnormal osteocyte morphology, and altered expression of osteocyte-derived proteins. These findings underscore the multifaceted impact of the mutant PTH1R on bone physiology and focus attention on the osteocyte as a cellular target for therapeutic intervention. Whether normalizing gene expression in osteocytes is possible and can improve bone health in JMC patients remains to be seen. Assessment of osteocyte morphology and function may provide novel diagnostic endpoints for future clinical trials with JMC therapeutics.
The Role of Science in Democracy: John Dewey as a Foil to Frank Knight
Authors: Tauzin Dillon , Woltz Kaitlyn 
Published: February 2025

Abstract
Frank Knight—known primarily for his contributions to neoclassical economic theory—was, throughout his career, more concerned with expressing the boundaries of that theory. His preoccupation with democracy motivated his constant admonitions about the limitations of economic science for the purpose of social reform. It makes sense, then, that John Dewey's scientific conception of democracy elicited a strong reaction in Knight. Knight's foundational concerns, and some of his more enigmatic views, can be better understood with reference to his criticism of Dewey. The basic lesson Knight wanted to express to the economics profession, and to the public generally, is that the kind of intelligence that is relevant in addressing social problems is different from the kind embodied in the scientific method.
Older Women’s Health: Protocol for a Randomized Trial Involving Power Training and Resistance Training with Elastic Bands
Authors: Bavaresco Gambassi Bruno , Schwingel Paulo Adriano , Gomes Lucas Tavares , Rodrigues Cintia Sousa , Matos da Silva Antonio Ricardo , Filho Wellington Fernandes Maciel , Leite Thiago Gomes , Costa Chaves Luiz Filipe , Ramirez-Campillo Rodrigo 
Published: February 2025

ABSTRACT

Context
Despite the benefits of exercise for older people’s health, there is little research on exercise with elastic bands and arterial stiffness and hemodynamic markers, specifically for older women. Such research is important because women tend to live longer than men and comprise most of the older adult population.

Objective
The aim of this study is to investigate the effects of different protocols with elastic bands on older women’s arterial stiffness, hemodynamic markers, functional parameters, and body composition.

Design
The study will be a randomized controlled trial.

Setting
This study focuses on the possibilities of low-cost and easily accessible training to improve arterial stiffness and hemodynamic markers in older women.

Participants
Participants will be 30 older women (≥65 yr).

Intervention
The women will be randomly assigned to either a dynamic power training plus endurance training group (DPTG) (n = 15) or dynamic traditional resistance training plus endurance training group (DRTG) (n = 15). Training will be performed twice a week over 12 wk using moderate-intensity elastic bands. Sessions will include seven exercises performed continuously in a circuit-like format. DRTG will use 2 s of movement velocity for both the concentric and eccentric phases of each exercise, whereas DPTG will perform the concentric phase as quickly as possible. DRTG will also perform a squat exercise, whereas DPTG will perform a countermovement jump. Both intervention groups will perform the same volume of moderate-intensity endurance training.

Main Outcome Measures
The outcome measures will be arterial stiffness and hemodynamic markers (primary outcome), and functional parameters and body composition (secondary outcome).

Conclusion
Because the intervention requires only elastic bands and a chair, this study protocol can be easily applied. In addition to being low cost, the intervention can be utilized almost anywhere (e.g., in public spaces and rehabilitation centers).
EVALUATION OF THE CONTENT OF MACRO- AND MICROELEMENTS IN THE LEAVES OF GARDEN STRAWBERRY (FRAGARIA ANANASSA DUCH.) UNDER DIFFERENT MINERAL NUTRITION SYSTEMS
Authors: Kotelnikova Anna D. , Shishkin Mikhail A. , Bamatov Ibragim M. 
Published: February 2025

The use of mineral fertilizers is a necessary practice that contributes to realizing the yield potential of crops. However, the efficiency of nutrient utilization by plants remains low, which can lead to non-productive losses and negative environmental consequences. One of the possible solutions is the use of fertilizers of prolonged action, including modern Russian developments in the field of polymer-modified fertilizers (PMFs). In this work we evaluated the changes in the content of a number of elements (Ca, P, K, Mg, Cu, Zn, Mn, Fe) in the leaves of strawberry (Fragaria ananassa Duch.) cultivars Elizaveta-2, Profusion, Irma under the conditions of different nutrition systems – without fertilizers, with the application of traditional mineral fertilizers, the author's system with the use of PMF (with a polymer content of 5% and 10%) and with the use of a foreign analog of PMF. Strawberry plants were grown under greenhouse conditions, and leaf samples were taken at three vegetative stages – the stage of formation of white fruits, the stage of beginning of fruit ripening, and the stage of ripe fruits. Elemental analysis of the leaves was performed by inductively coupled plasma optical emission spectrometry (ICP-OES). Differences between strawberry cultivars and between nutrition systems for plants of the same cultivar were found. At the same time, according to the results of the evaluation of the changes in the content of a number of macro- and microelements in the leaves of strawberry plants at different stages of vegetation under different nutrition systems, no striking regularities were observed that would be characteristic of each variety used in the experiment. However, the increase in the content of Ca, Mg, Cu and Fe observed in a number of cases when using the author's nutrition system may indicate the improvement in the conditions for the uptake of these nutritional elements when using PMF.
Funding. This work was supported by Russian Science Foundation grant No. 22-16-00092.
IN VITRO RESPONSE OF COTINUS COGGYGRIA SCOP. TO THE SPETRAL RADIATION AND LEDS INTENSITY
Authors: Zholobova Olga O. , Mogilevskaya Irina V. 
Published: February 2025

Background. Modern wide-spectrum LED installations' application under strictly controlled conditions with the correct choice of the quantitative and qualitative light composition helps the microclonal propagation of species Cotinus coggygria Scop., used in agroforestry, landscaping, and pharmaceuticals.
Purpose. Choosing the best photomorphogenesis parameters in vitro on a hormone-free medium for C. coggygria as a perspective plant species for commercial uses.
Materials and methods. The effect of 15 lighting options, namely 6 ratios of red (R), blue (B), and green (G) spectra, on the composition of LEDs on C. coggygria explants in vitro by methods used in microclonal propagation was studied. The biochemical parameters’ content in the samples of the studied leaves was determined using the optical method. Statistical data processing was carried out using the Statistica 12.0 application package (StatSoft, USA).
Results. Determining the parameters of regenerants and leaf plates cultivated in vitro, as well as the pigment leaves’ composition, made it possible to select the optimal spectral ratio (1R:1B:0.5G) and PPFD values (40–70 µmol m-2 s-1) to obtain maximum results at cultivation on a hormone-free medium according to the Murashige and Scoog protocol. During the analysis of C. coggygria biochemical leaf composition, the maximum total chlorophyll amounts (17-21.5 μg cm2) and NBI (67.8-71.0 с.u.) and the minimum flavonoids and anthocyanins amounts were obtained, which confirms the normal photosynthetic’ apparatus work of the studied microshoots.
Conclusion. The results obtained can be recommended to be used for optimizing the micropropagation technology of C. coggygria.
Funding. The research was carried out within the framework of the state assignment of the Ministry of Science and Higher Education of the Russian Federation No.122020100427-1 To develop a scientific basis for the preservation and reproduction of valuable wood and shrubs genotypes in culture in vitro.
The Impact of Antibiotics on the Development of Colorectal Cancer – A Review of Current Insights and Directions for Future Research
Authors: Zagórski Karol , Kozik Mateusz , Skalska-Dziobek Nina , Małagocka Weronika , Chybowska Karolina , Naruszewicz Maria , Cetnarowski Przemysław 
Published: February 2025

Introduction and purpose: Colorectal cancer (CRC) is one of the most common neoplasms in the world. In Poland, CRC has a third place in incidence. There are numerous well-established risk factors for CRC, such as a western diet, low physical activity, alcohol consumption, and cigarettes smoking. Currently, the role of the colonic microbiome and the overuse of antibiotics is also highlighted in the pathogenesis of CRC. This review aims to assess the impact of antibiotic use on CRC risk, clinical characteristics, and pathological features.

Material and methods: A comprehensive literature search was conducted through the following databases: PubMed, Cochrane Library, Embase, and Google Scholar. Systematic reviews, meta-analyses, clinical trials and observational studies were included if they were relevant and provided data on the influence of antibiotics on CRC.

State of knowledge: This review identified several key systematic reviews with meta-analyses of observational studies indicating that antibiotics have an impact on the onset, time of development, and localisation of CRC. The classes and spectrum of antibiotics were found to differ in the risk of occurrence of CRC.

Summary: Recently, great progress has been made in understanding a variety of antibiotics-microbiota-cancer interactions. However, further research is needed to deepen our knowledge about the contribution of antibiotic use to CRC. Clinicians should carefully consider the benefits and risks of prescribing antibiotics, including possible long-term adverse events such as cancer onset.
A Study on the psychometric properties of the Chinese version of the Parent Tic Questionnaire
Authors: Ding Qiang , Woods Douglas W. , Barber Kathryn E. , Xu Wen , Zhao Ying , Shen Shuqin , Sun Jinhua 
Published: February 2025

Introduction
The Parent Tic Questionnaire (PTQ) is a tool for parents to assess their child’s tic severity, but its effectiveness in non-Western contexts like China has not been thoroughly examined. This study aimed to evaluate the psychometric properties of the PTQ in assessing motor and vocal tic severity among Chinese children diagnosed with tic disorders.

Method
Parents of 268 Chinese children and adolescents aged 6–17 years, diagnosed with tic disorders, completed the PTQ. The study assessed tic severity using the Yale Global Tic Severity Scale (YGTSS) and PTQ. Additionally, obsessive-compulsive symptoms were measured using the Children Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and other behavioral problems were evaluated using the Conners’ Parent Rating Scale (CPRS-48).

Results
The PTQ showed acceptable to good internal consistency (Cronbach’s alpha = 0.67 for motor, 0.77 for vocal, and 0.79 for total tic scores) and acceptable to good two-week test-retest reliability (intraclass correlations, ICC = 0.74 for motor, 0.81 for vocal, and 0.79 for total tic scores). It demonstrated good convergent validity with the YGTSS and effective discriminant validity from obsessive-compulsive and internalizing symptoms (i.e., anxiety and psychosomatic). Furthermore, our analysis revealed significant variability in item difficulty across the questionnaire, indicating differences in how various tics are perceived and reported by Chinese parents, which may influence the assessment’s accuracy and reliability.

Discussion
The findings indicate that the Chinese version of the PTQ is a reliable and valid tool for assessing tic severity in Chinese children with tic disorders, offering significant implications for clinical assessment in diverse cultural contexts. Additionally, our findings on item difficulty highlight the need for further cultural adaptations of the PTQ.
Quality of evidence in the oral health international data: Contributions for a global profile
Authors: Queiroz Marques dos Santos Sophia , Giuseppe Roncalli da Costa Oliveira Angelo 
Published: February 2025

Introduction
The Oral Health Country/Area Profile Project (CAPP) is the largest global database on oral health, compiling information from 205 countries, including 193 members of the World Health Organization (WHO). Although this database is a source of information and provides an overview of global oral health, the extent to which it accurately reflects oral health in specific countries is uncertain.

Objective
To analyze the quality of evidence underlying the global oral health profile provided by CAPP.

Methods
The Appraisal tool for Cross-Sectional Studies (AXIS) was adapted and used to assess data extracted from the methods section of included records. The results were then analyzed using the Item Response Theory (IRT) to establish the weightings of each dimension. The score was assessed in relation to variables of interest: age group, year of the record, and geographic region.

Results
The quality of oral health data showed polarization, with The quality of data from included documents varied according to age group analyzed, year of assessment, and geographic region. The Americas and Western Pacific regions demonstrated the highest quality of oral health data.

Conclusion
The global oral health profile depicted by CAPP may not accurately reflect reality. The process for including data in the database needs to be reviewed to ensure its reliability.
Caesarean section delivery and its associated factors in Ghana: A multilevel analysis
Authors: Tilahun Werkneh Melkie , Simegn Mulat Belay , Abate Alegntaw , Golla Eyasu Bamlaku , Ali Mohammed Ahmed , Kumbi Hawi , Wondie Smegnew Gichew , Geremew Habtamu 
Published: February 2025

Background
Even if the ideal rate for caesarean section (CS) is considered 10–15%, worldwide CS rates have been steadily increasing, without significant additional benefit to women’s health. Its overuse was associated with maternal and fetal complications. Therefore, this study aimed to determine the rate of CS delivery and associated factors among women delivered in health facilities in Ghana.

Methods
A cross-sectional study was conducted using the 2022 DHS datasets from Ghana. A total of 5231 weighted samples were included. STATA.16 was used for analysis. A multilevel logistic regression was applied. An adjusted odds ratio with a 95% CI and a p-value <  0.05 was used to declare significantly associated factors.

Result
The prevalence of CS in Ghana was 20.29% [95% CI = 19.23–21.41%]. Age 25-34 [AOR = 1.32, CI: 1.04, 1.68] and 35 + [AOR = 1.57, CI: 1.16, 2.11], primary [AOR = 1.58, CI: 1.21, 2.07], secondary [AOR = 1.36, CI: 1.07, 1.73], and higher [AOR = 2.24, CI: 1.58, 3.17] education, richer [AOR = 1.45, CI: 1.06, 1.99] and richest [AOR = 2.35, CI: 1.63, 3.39] wealth index, employment [AOR = 0.77, CI: 0.64, 0.92], primiparous [AOR = 1.33, CI: 1.07, 1.67], giving first birth after the age of 35 [AOR = 4.58, CI: 1.88, 11.19], multiple pregnancy [AOR = 5.53, CI: 4.02, 7.62], large birth size [AOR = 1.25, CI: 1.06, 1.48], 4–6 kg birth weight [AOR = 2.13, CI: 1.55, 2.92], as well as residing in Volta [AOR = 1.98, 95% CI: 1.22, 3.22] and Bono East [AOR = 2.02, 95% CI: 1.28, 3.19] regions were significant factors associated with CS delivery in Ghana.

Conclusion
The rate of CS was higher than previous studies in Ghana and the WHO recommended level, making it a public health concern. Age, education, wealth, employment, parity, age at first birth, pregnancy type, birth size, birth weight, and region were significantly associated with CS. Therefore, strategies aimed at examining guidelines for proper indications and uses of CS may lead to an improvement CS rate.
Understanding Fashion Scandals: Social Media, Identity, and Globalization, Annamari Vänskä and Olga Gurova (2024)
Authors: von Wachenfeldt Paula 
Published: February 2025

Review of: Understanding Fashion Scandals: Social Media, Identity, and Globalization, Annamari Vänskä and Olga Gurova (2024)
London: Bloomsbury Publishing, 235 pp.,
ISBN 978-1-35024-896-0, h/bk, £15.11
Reorienting Public Agriculture R&D to Achieve Resilient and Sustainable Food and Agriculture System in Indonesia
Authors: Sudaryanto Tahlim , Suryana Achmad , Purba Helena Juliani , Rafani Iqbal , Maghraby Wahida , Yofa Rangga Ditya , Savitri Sheila , Zhou Yuan , Kretschmer Alva 
Published: February 2025

<p>Indonesia's agriculture is evolving towards modern, high-value, and market-driven practices, aligning with Sustainable Development Goals (SDGs). Technological change, markets, institutions, climate change, and government policies influence the performance of agriculture. The government plays a major role in agricultural innovation through investment in agricultural Research and Development (R&amp;D), focusing on food and nutrition security, climate resilience and sustainability, and agricultural transformation. This paper aims to analyze the level and structure of agricultural R&amp;D funding in Indonesia and draw recommendations for reorienting future agriculture R&amp;D priorities. The analysis is based on a series of focused group discussions and secondary data from related stakeholders, enriched by information from the literature review. This study assesses Indonesia's agricultural R&amp;D funding, finding it minimal at less than 0.2% of agricultural GDP, mostly public-funded. Farmers are slow to adopt these innovations despite substantial spending on technology dissemination. Gaps exist in accelerating agricultural transformation and technology adoption. Based on the findings, we propose seven recommendations for reorienting the R&amp;D funding, including increasing the funding level of public research and better disseminating research results</p><p> </p>Keywords: agricultural R&amp;D, gaps, recommendation, reorienting, Indonesia