bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Minimal Clinically Important Difference for the Oswestry Disability Index Substantially Varies Based on Calculation Method
Authors: Solomito Matthew J. , Kia Cameron , Makanji Heeren 
Published: June 2024

Study Design.
Retrospective study.

Objective.
Evaluate differences in the minimal clinically important difference (MCID) threshold value based on various acceptable statistical methods, and how these differences may influence the interpretation of surgical benefit following elective 1 and 2 level lumbar fusion.

Summary of Background Data.
The MCID is a statistically determined threshold value to evaluate if a patient has received benefit from a medical procedure. In the era of value based medicine, the MCID has become increasingly important. However, there is substantial ambiguity surrounding the interpretation of this value given that it can be influenced by both demographic and methodological factors.

Methods.
371 patients that underwent one or two level elective lumbar fusion between June 2021 and June 2023 were included in this study. All patients completed both their preoperative and 6 month post-operative Oswestry Disability Index (ODI), as well as two anchor questions concerning satisfaction with their surgical procedure. The MCID values were calculated using 16 accepted statistical methods, and the resulting MCID values were applied to the cohort to determine how many patients reached MCID by 6 months post fusion.

Results.
Results demonstrated significant variability in the MCID value. The average MCID value for all 16 methods was 10.5±7.0 points range (0.8 to 25). Distribution methods provided lower threshold MCID values but had greater variability while the Anchor methods resulted in higher threshold values but had lower variability. Depending on the method used 30 to 83% of the cohort reached MCID by 6 months.

Conclusion.
The statistical method used to calculate the MCID resulted in significantly different threshold values, and greatly affected the number of patients meeting MCID. The results demonstrates the complexity surrounding the interpretation of MCID values, and calls into question the utility of a single statistically determined value to assess surgical success.
Comparing Collagenase and Tissue Subcision for Cellulite Treatment of the Buttock and Thigh Regions: A Systematic Review and Meta-analysis
Authors: Foppiani Jose A. , Raska Otakar , Galinaud Cécilia , Stearns Stephen , Hernandez Alvarez Angelica , Taritsa Iulianna C. , Schuster Kirsten A. , Ho Olivia A. , TerKonda Sarvam , Lee Bernard T. , Lin Samuel J. 
Published: June 2024

Background:
In this systematic review, we assessed the therapeutic efficacy and safety of Clostridium histolyticum collagenase (CCH) and tissue subcision (TS) for treating cellulite, which ranges from subtle to pronounced lesions.

Methods:
A systematic review was performed following PRISMA guidelines for CCH and TS treatment to the thigh and gluteal regions. A proportion meta-analysis was then conducted using Stata statistical software.

Results:
A total of 14 studies were incorporated into the final analysis. Nine focused on TS and five on CCH injection, collectively reporting outcomes for 1254 patients. Of these, 465 received CCH injection and 789 underwent subcision. For bruising, rates were 89% [95% confidence interval (CI), 71%–96%] with CCH injection and 99% (95% CI, 85%–99%) for subcision; pain requiring analgesic was reported at 74% (95% CI, 55%–87%) for CCH and 60% (95% CI, 43%–76%) for subcision; both showed induration at 7% (95% CI, 5%–11% for CCH, 95% CI, 2%–25% for subcision), whereas skin discoloration was higher post-CCH injection at 16% (95% CI, 10%–26%) compared with 7% (95% CI, 5%–10%) postsubcision.

Conclusions:
Both CCH and TS seem effective treatments for cellulite. However, upon evaluating the adverse outcomes between the two modalities, subcision demonstrated a higher incidence of bruising, albeit similar rates of induration compared with CCH injection. Conversely, the CCH injection group manifested a higher propensity for pain requiring analgesia and notably exhibited increased instances of skin discoloration compared with their subcision patient group. Further standardized research is crucial for more informed cellulite treatment decisions and for comparing efficacy, safety, and cost-effectiveness between TS and CCH.
Aldosterone-independent regulation of K+ secretion in the distal nephron
Authors: Demko John , Weber Robert , Pearce David , Saha Bidisha 
Published: June 2024

Purpose of review
Maintenance of plasma K+ concentration within a narrow range is critical to all cellular functions. The kidneys are the central organ for K+ excretion, and robust renal excretory responses to dietary K+ loads are essential for survival. Recent advances in the field have challenged the view that aldosterone is at the center of K+ regulation. This review will examine recent findings and propose a new mechanism for regulating K+ secretion.

Recent findings
Local aldosterone-independent response systems in the distal nephron are increasingly recognized as key components of the rapid response to an acute K+ load, as well as playing an essential role in sustained responses to increased dietary K+. The master kinase mTOR, best known for its role in mediating the effects of growth factors and insulin on growth and cellular metabolism, is central to these aldosterone-independent responses. Recent studies have shown that mTOR, particularly in the context of the “type 2” complex (mTORC2), is regulated by K+ in a cell-autonomous fashion.

Summary
New concepts related to cell-autonomous K+ signaling and how it interfaces with aldosterone-dependent regulation are emerging. The underlying signaling pathways and effectors of regulated K+ secretion, as well as implications for the aldosterone paradox and disease pathogenesis are discussed.
Combined Efficacy of Nimotuzumab and Gemcitabine on the Treatment of Advanced Pancreatic cancer
Authors: Li Yi , Li Dan , Liu Qianqian , Li Jun 
Published: June 2024

Objective
We sought to investigate whether the addition of nimotuzumab to gemcitabine would improve the treatment efficacy of advanced pancreatic cancer.

Methods
This retrospective analysis involved a total of 98 hospitalized patients harboring advanced pancreatic cancer. Depending on the specific treatment, patients were divided into study groups and control groups. The clinical efficacy, adverse reactions, and follow-up results of the 2 groups were compared, and the physical status, CA724, CA19-9, and CEA levels before and after treatment were monitored and recorded.

Results
After treatment, PR ratio, SD ratio, ORR, and DCR in the study group were significantly higher than those in the control group, and PD ratio was significantly lower than that in the control group (P < 0.05) the KPS score after treatment in the study group was markedly higher than that of the control group (P < 0.05). After treatment, however, significantly lower levels of the 3 indicators were observed when compared with the control group (P < 0.05).

Conclusion
Our study highlights a more superior combined efficacy of nimotuzumab and gemcitabine than the control regimen, exhibiting improved survival and reduced levels of CA724, CA19-9, and CEA in patients with advanced pancreatic cancer.
Simulation-Based Training Program for Peripherally Inserted Central Catheter Placement
Authors: Corvetto Marcia A. , Kattan Eduardo , Ramírez Gaspar , Besa Pablo , Abbott Eduardo , Zamorano Elga , Contreras Víctor , Altermatt Fernando R. 
Published: June 2024

Introduction
Simulation training that includes deliberate practice is effective for procedural skill training. Delivering feedback remotely and asynchronously has been examined for more cost-efficient training. This prospective randomized study aimed to compare 2 feedback techniques for simulation training: synchronous direct feedback versus asynchronous distance feedback (ASYNC).

Methods
Forty anesthesia and internal medicine residents were recruited after study approval by the institutional ethics committee. Residents reviewed instructional material on an online platform and performed a pretraining assessment (PRE) for peripherally inserted central catheter (PICC) placement. Each resident was then randomly assigned to 1 of 2 training types, practice with synchronous direct feedback (SYNC) or practice with ASYNC. Training consisted of four, 1-hour practice sessions; each was conducted once per week. Both groups underwent posttraining evaluation (POST). The PRE and POST assessments were videotaped and evaluated by 2 independent, blinded reviewers using a global rating scale.

Results
Thirty-five residents completed the training program and both evaluations. Both groups had significantly improved global rating scale scores after 4 sessions. The SYNC group improved from 28 to 45 points (P < 0.01); the ASYNC group improved from 26.5 to 46 points (P < 0.01). We found no significant between-group differences for the PRE (P = 0.42) or POST assessments (P = 0.13).

Conclusion
This simulation-based training program significantly improved residents' peripherally inserted central venous catheter placement skills using either modality. With these results, we are unable to demonstrate the superiority of synchronous feedback over ASYNC. Asynchronous feedback training modality represents a new, innovative approach for health care procedural skills training.
CODI: Enhancing machine learning-based molecular profiling through contextual out-of-distribution integration
Authors: Eissa Tarek , Huber Marinus , Obermayer-Pietsch Barbara , Linkohr Birgit , Peters Annette , Fleischmann Frank , Žigman Mihaela 
Published: June 2024

ABSTRACTMolecular analytics increasingly utilize machine learning (ML) for predictive modeling based on data acquired through molecular profiling technologies. However, developing robust models that accurately capture physiological phenotypes is challenged by a multitude of factors. These include the dynamics inherent to biological systems, variability stemming from analytical procedures, and the resource-intensive nature of obtaining sufficiently representative datasets. Here, we propose and evaluate a new method: Contextual Out-of-Distribution Integration (CODI). Based on experimental observations, CODI generates synthetic data that integrate unrepresented sources of variation encountered in real-world applications into a given molecular fingerprint dataset. By augmenting a dataset with out-of-distribution variance, CODI enables an ML model to better generalize to samples beyond the initial training data. Using three independent longitudinal clinical studies and a case-control study, we demonstrate CODI’s application to several classification scenarios involving vibrational spectroscopy of human blood. We showcase our approach’s ability to enable personalized fingerprinting for multi-year longitudinal molecular monitoring and enhance the robustness of trained ML models for improved disease detection. Our comparative analyses revealed that incorporating CODI into the classification workflow consistently led to significantly improved classification accuracy while minimizing the requirement of collecting extensive experimental observations.SIGNIFICANCE STATEMENTAnalyzing molecular fingerprint data is challenging due to multiple sources of biological and analytical variability. This variability hinders the capacity to collect sufficiently large and representative datasets that encompass realistic data distributions. Consequently, the development of machine learning models that generalize to unseen, independently collected samples is often compromised. Here, we introduce CODI, a versatile framework that enhances traditional classifier training methodologies. CODI is a general framework that incorporates information about possible out-of-distribution variations into a given training dataset, augmenting it with simulated samples that better capture the true distribution of the data. This allows the classification to achieve improved predictive performance on samples beyond the original distribution of the training data.
CLIENT SATISFACTION ON CERVICAL CANCER SCEENING AND ITS ASSOCIATED FACTORS AMONG SCREENED WOMEN IN NORTH WOLLO PUBLIC HOSPITALS, ETHIOPIA
Authors: Ejigu Betelhem , Dilnesa Tenagnwork , Ebrahim Toyba , Mulugeta Chaile , Susu Belay , Emagneh Tadele 
Published: June 2024

AbstractBackgroundCervical cancer is one of the very few cancers where pre-cancer lasts many years before becoming invasive cancer providing an opportunity for detection and treatment. It is leading cause cancer death where less attention is given for screening programs in sub-Saharan Africa. For this satisfaction of cervical cancer screening have a role in increasing utilization and quality of serviceMethodsA facility based cross-sectional study design was used to assess client satisfaction and its associated factor towards cervical cancer screening. Data was collected from 397 samples using a face to face interview in women who take cervical screening test in the selected health facilities. Data was entered to Epi info version 4.6 and bivariable and multivariable logistic analysis was done using SPSS version 25 and p value <0.05 was considered to be significant factors associated with cervical cancer screening serviceResultfrom 397 interviewed women, 59% (236) were satisfied with cervical cancer screening services. One-hundred fourty five (36.5%) women had good comprehensive knowledge of cervical cancer screening. Satisfaction with cervical cancer screening service was statistically associated with Being house wife (AOR= 0.42(0.19-0.95), who attend Primary and secondary secondary (AOR =0.35(0.12-0.99) waiting time 31-60 min (AOR=0.14(0.06-0.33) and who went 1-5 km to the facility (AOR=0.41(0.19-0.90)ConclusionThe study findings indicated that greater than half of women were satisfied with cervical cancer screening service in North wollo public hospitals. Less than half of women had good knowledge about cervical cancer. The study revealed occupational status, educational status, waiting time, and distance to the facility were found to be significantly associated with cervical cancer screening satisfaction
Experienced inclusion and recognition amongst people with spinal cord injury: A comparative study in Norway, The Netherlands, and Australia
Authors: Leiulfsrud Annelie Schedin , Ellinggard Kristian Bernhof , Post Marcel W.M. , Arora Mohit , Leiulfsrud Håkon 
Published: June 2024

AbstractBackgroundThe aim of this article is to study inclusion and recognition experienced amongst people with a Spinal Cord Injury (SCI) in Norway, The Netherlands, and Australia. This is approached both from the perspectives of an interest in the impact of mobility limitations versus social attitudes, and from a consideration of differences between societies.MethodsThe data derive from the core questionnaire of International Spinal Cord Injury Community Survey with extended national modules on the attitudes and values of respondents from Norway, The Netherlands, and Australia. The data gathered in 2017-18 include 2,450 participants aged 18 years or older. The data are analysed and presented with descriptive statistics and OLS regression analyses. In order to explore our main questions, we run regression controlling for country effects in addition exploring within country effects.ResultsMobility limitations are a substantially weaker predictor of self-perceived inclusion and recognition than experiences of negative attitudes towards disabled people. Stereotypical attitudes and norms in society are shown to have various impacts on inclusion in the three countries. The Norwegian respondents report overall better results on inclusion and recognition than respondents in Australia and The Netherlands, illustrating the importance of national contexts.ConclusionsChallenges associated with inclusion, recognition, and respect after SCI need to be defined in a language broader than mobility limitations and stereotypical attitudes towards people with an SCI. The main road to both inclusion and recognition in society is primarily linked to job and educational status, in addition to family and friends. The results are of particular interest as measures to support reintegration into society, including a strengthening of labour market integration programs.
THE USE OF AN OBJECTIVE METHOD (CONTINUOUS EXOSOMATIC ELECTRODERMAL ACTIVITY WITHOUT EXTERNAL STIMULI) TO EVALUATE PATIENTS WITH HYPERHIDROSIS UNDERGOING VIDEO-ASSISTED SYMPATHECTOMY
Authors: Silveira Rafael José , Sorbello Carolina Carvalho Jansen , Wolosker Nelson , de Campos José Ribas Milanez , Cardoso João José de Deus , Onofre Alexandre Sherlley Casimiro 
Published: June 2024

2.ABSTRACTObjectiveTo objectively assess continuous exosomatic electrodermal activity without external stimuli in primary hyperhidrosis patients, before and after sympathectomy and compare it with responses to clinical investigation questionnaires.MethodIn a prospective study, 28 participants were divided into two groups. The first group consisted of 18 patients with palmoplantar hyperhidrosis who underwent sympathectomy on the fourth and fifth costal arches, bilaterally and sequentially. The second group, serving as a control, consisted of 10 patients. The assessment involved 2 self-explanatory questionnaires; the control group completed the questionnaires once, while the sympathectomy group completed them before surgery, one day and 30 days later. Sweating was objectively evaluated by measuring electrodermal activity (EDA) using the MP36R biosensor from Biopac Systems Inc. USA. This was done by carrying out measurements before surgery, on the first postoperative and on the thirtieth postoperative using an exosomatic technique and a constant electrical flow. Measurements were taken sequentially from the hands and feet, for 5 uninterrupted minutes at each site, after 10 minutes of rest, in a comfortable sitting position, without external stimuli, and in an air-conditioned environment. The study also collected anthropometric, clinical, and surgical data, and no significant sociodemographic differences were observed between the groups.ResultsIn the group that underwent thoracic sympathectomy, there was a significant improvement in quality of life and a reduction in palmar and plantar sweating, as assessed by the questionnaires. Electrodermal activity showed significantly higher levels in the hands and feet of patients with hyperhidrosis compared to the control group during the preoperative assessment. After surgery, there was a reduction in electrodermal activity in the hands, and 100% of the sample analyzed showed a decrease in sweating. As for the evaluation of the feet, 67% of the patients reported a reduction in sweating, and 44% showed a statistically significant decline in EDA.ConclusionContinuous exosomatic electrodermal activity without external stimuli is a suitable method for assessing patients with palmoplantar hyperhidrosis, with appropriate clinical correlation compared to the questionnaire’s answers quantifying sweating and quality of life.
Recurrent stroke prediction by applying a stroke polygenic risk score in the Japanese population
Authors: Kojima Naoki , Koido Masaru , He Yunye , Shimmori Yuka , Hachiya Tsuyoshi ,   BioBank Japan, Debette Stéphanie , Kamatani Yoichiro 
Published: June 2024

AbstractBackgroundRecently, various polygenic risk score (PRS)-based methods were developed to improve stroke prediction. However, current PRSs (including cross-ancestry PRS) poorly predict recurrent stroke. Here, we aimed to determine whether the best PRS for Japanese individuals can also predict stroke recurrence in this population by extensively comparing the methods and maximizing the predictive performance for stroke onset.MethodsWe used data from the BioBank Japan (BBJ) 1stcohort (n=179,938) to derive and optimize the PRSs using a 10-fold cross-validation. We integrated the optimized PRSs for multiple traits, such as vascular risk factors and stroke subtypes to generate a single PRS using the meta-scoring approach (metaGRS). We used an independent BBJ 2ndcohort (n=41,929) as a test sample to evaluate the association of the metaGRS with stroke and recurrent stroke.ResultsWe analyzed recurrent stroke cases (n=174) and non-recurrent stroke controls (n=1,153) among subjects within the BBJ 2ndcohort. After adjusting for known risk factors, metaGRS was associated with stroke recurrence (adjusted OR per SD 1.18 [95% CI: 1.00–1.39, p=0.044]), although no significant correlation was observed with the published PRSs. We administered three distinct tests to consider the potential index event bias; however, the outcomes derived from these examinations did not provide any significant indication of the influence of index event bias. The high metaGRS group without a history of hypertension had a higher risk of stroke recurrence than that of the low metaGRS group (adjusted OR 2.24 [95% CI: 1.07–4.66, p=0.032]). However, this association was weak in the hypertension group (adjusted OR 1.21 [95% CI: 0.69–2.13, p=0.50]).ConclusionsThe metaGRS developed in a Japanese cohort predicted stroke recurrence in an independent cohort of patients. In particular, it predicted an increased risk of recurrence among stroke patients without hypertension. These findings provide clues for additional genetic risk stratification and help in developing personalized strategies for stroke recurrence prevention.
Temporal dynamics of gene expression during metamorphosis in two distantDrosophila species
Authors: Ozerova AM , Kulikova DA , Evgen’ev MB , Gelfand MS 
Published: June 2024

AbstractComplete metamorphosis of holometabolous insects is a complex biological process characterized by profound morphological, physiological, and transcriptional changes. To reveal the temporal dynamics of gene expression during this critical developmental transition, a detailed analysis of the developmental transcriptomes of two Drosophila species,Drosophila melanogasterandDrosophila virilis, was conducted. We confirm partial recapitulation of the embryonic transcriptional program in pupae, but instead of the traditional hourglass model, which posits maximal conservation at mid-embryonic stages, at different stages of pupae we observe a more complicated pattern of alternating low and high diversity, resembling an inverted hourglass, or "spindle", that underscores the complexity of developmental processes during complete metamorphosis. Notably, recently formed genes (specific to insects) exhibit pronounced expression peaks during mid-pupal development, indicating their potential role in developmental transitions.Significance StatementThis study describes the transcriptomic dynamics of complete metamorphosis in holometabolous insects. By analyzing developmental transcriptomes ofDrosophila melanogasterandDrosophila virilis, we characterize the spindle pattern of gene expression during pupal stages, contrasting with the classical hourglass model of embryogenesis. This alternating pattern of low and high transcriptional diversity highlights the unique complexity of metamorphose processes.