bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nocturia Overview: a survey from General Practitioners in Indonesia
Authors: Indraswari Madhyra Tri , Rahardjo Harrina Erlianti 
Published: May 2024

Link Video Abstract: https://youtu.be/5cvWJq-8s0w

Background: Nocturia is the need or the number of waking up at night to urinate, with each void preceded and followed by sleep. It is included in lower urinary tract symptoms and reported as the most bothersome and common. Nocturia causes long term sleep deprivation and lowers someone's quality of life. Thus, they need to know how to diagnose and treat nocturia, including time to refer to a specialist. This study aims to review the management and diagnosis of nocturia among Indonesian general practitioners.
Methods: This study used cross sectional design. The data was collected by distributing a self-made online survey with Google Forms about the overview of nocturia among general practitioners in Indonesia, taken from October 2021 to March 2022. Data were analyzed using SPSS version 20.0 for Windows.
Results: There were 252 participants in this study that filled in the questionnaire from October 2021 to March 2022. Most patients (57.8%) were between 50 and 65 years old. Different approaches for nocturia were made, with mainly chose education and lifestyle change (88.1%) and medication such as alpha blocker (19.8%) compared to desmopressin (13.5%). Only 65.5% of respondents referred their patients to urologists for further therapy.
Conclusion: General practitioners in Indonesia face difficulty in dealing with nocturia. It is better to refer these patients to a urologist or other related specialist after they perform the diagnostic examinations and standard therapy.
Workplace interventions to overcome stigma and depression in patients with Multiple drug-resistant tuberculosis (MDR TB)
Authors: Mawey Feytie Magda , Karimah Azimatul , Kusmiati Tutik 
Published: May 2024

Introduction: MDR-TB is an infectious disease that can cause death and stigma for those infected. MDR-TB patients with depression are at risk for LTFU, which will worsen their condition and strengthen the stigma they receive.
Case report: A 52-year-old female psychiatric interview and assessment using the Beck Depression Inventory (BDI) found that BDI score of 4 (no depression), and the patient adhered to TB treatment. She was found to be laid off, and an assessment using the BDI to detect depression in the patient found potential stigma in the patient, such as being laid off from work, prohibited from teaching face-to-face, and shunned by colleagues. Interventions given were prescribing Fluoxetine 20 mg per day and Clobazam 10 mg per day, a brief intervention using the FRAMES technique, psychoeducation about disease and drug effects and the duration of treatment, and an office visit. A worksite intervention was performed by the patient's husband. Antituberculosis drugs were monitored by both a pulmonologist and a psychiatrist. Her work-related problems were resolved through interventions at the school with psychoeducation about drug-resistant tuberculosis, the transmission method, the duration of treatment, and the side effects of the treatment. The results of the last sputum examination after one month of treatment showed drug resistance, and the patient was advised to undergo 18 months of treatment. The patient could finally work offline with fewer responsibilities after getting negative laboratory test results twice in a row.
Conclusion Work-related psychosocial interventions are required to address rejection at work, which results in depression and nonadherence to treatment. Liaison services with social interventions at work in drug-resistant tuberculosis-infected patients are necessary to improve their quality of life and maintain their treatment adherence.
The effect of bisphosphonate and platelet-rich plasma in anterior cruciate ligament reconstruction: an article review
Authors: Sibarani Tangkas , Purwanto Bambang , Mudigdo Ambar , Wasita Brian 
Published: May 2024

Link of Video Abstract: https://youtu.be/fn9kA601YVo
ACL rupture is a common injury often resulting from previously healthy individuals' non-contact knee injuries. ACL rupture in young adults and teenagers are becoming more common, contrary to earlier theories that suggested ACL damage was uncommon in skeletally immature people. This risk is significantly raised by concomitant meniscal injury whether or not an ACL reconstruction is undertaken. Although surgical management with allograft or autograft reconstruction can be achieved successfully, there are some serious complications following ACL reconstruction. The supply of autografts is limited, especially in situations with numerous ligament injuries or re-ruptures, which might result in morbidity at the donor site. Allografts can increase the spread of illness and trigger an inflammatory response, which is a drawback. There has been much interest in a tissue-engineered ACL graft because of these issues and current developments in bioengineering and regenerative medicine. According to recent research, following an ACL repair, the bone marrow density surrounding the knee area diminishes. Platelet Rich Plasma (PRP) and Bisphosphonate are the substrates that could ameliorate this phenomenon. Therefore, this review aims to compile evidence of PRP and bisphosphonate and its effect on the tendon-bone interface in ACL reconstruction.
A review of fit to work assessment program on the work performance of heavy equipment operators during the pandemic covid-19 at Indonesia
Authors: Ayu Friska , Nourma Muslikha , Sahri Moch , Hutapea Octavianus , Winarno Bondan 
Published: May 2024

Introduction: Fit-to-work assessment is one of the health examination efforts to assess the physical function and occupational health of workers before starting work. This fit-to-work assessment is very important during the current pandemic because the workplace is a place that is at risk of transmitting the COVID-19 virus, especially a workplace that continues to operate during the pandemic. Thus, this study aims to analyze the influence of fit-to-work assessment on the work performance of Heavy Equipment Operators at a port service terminal in Indonesia during the COVID-19 pandemic.
Methods: The type of research used descriptive analytics with the cross-sectional study. The sample was collected with a simple random sampling technique. The population in this study is heavy equipment operators in one of the sub-holding of PT. Pelindo Terminal Petikemas Surabaya- Indonesia with a sample of 54 operators who can represent each work shift. Each participant was given a questionnaire and needed to fulfill it. The data will be analyzed using SPSS 25. The data analyzed was descriptive only.
Results: According to the study of the characteristics, mostly the ages were 31-40 (46.30%), with a high prevalence of high school (76%). The work shift schedule was classified into three parts. Shift two from 3.30 pm until 11.40. The length of work was also more than five years or greater than others (59.25%), with the work performance from 54 respondents, we found that they had a high work performance (72%), and all of the respondents were mostly in a reasonable condition (94.04%).
Conclusion: Fit-to-work assessment is carried out before work to determine whether the worker is fit or unfit to work according to the level of health required. The work performance we found that mostly they have a high work performance. It was also in line with the fit-to-work assessment results that most respondents were in a reasonable condition.
The role of Platelet Rich Fibrin (PRF) membrane and conjunctival autograft on TGF-β and collagen type 1 expression in conjunctival wound healing: a literature review
Authors: Karisma I Nyoman Ananta , Sasono Wimbo , Fatmariyanti Susy 
Published: May 2024

Link of Video Abstract: https://youtu.be/8w4jBvx0pJc

Background: Plasma-rich fibrine (PRF) membrane is a new biomembrane useful in ocular surface reconstruction technique. Since its development, PRF membrane has been used successfully in many studies; however, some controversies maintained. This literature study aims to evaluate the role of Platelet Rich Fibrin (PRF) membrane and conjunctival autograft on TGF-β and collagen type 1 expression in conjunctival wound healing.
Methods: This literature review compiles and elaborates on previous studies from many authors to support future experimental studies, which will be conducted to compare the effect of PRF membrane and conjunctival autograft on TGF-β and type 1 collagen expression.
Results: PRF has many advantages, such as the ability to reduce inflammation, rich in growth factors, and can be a temporary scaffold for fibroblast migration. However, despite its advantages, PRF is not widely used, unlike its counterpart techniques, such as conjunctival autograft. Conjunctival autograft has long been used as an option for ocular surface reconstruction techniques, but it has some limitations. The conjunctival autograft technique cannot be performed in large or bilateral conjunctival damage. Thus, the PRF membrane technique can become a perfect solution for such a case. This literature review will provide more information on how PRF can regulate inflammation and support the conjunctival wound healing process.
Conclusion: Some impacts of PRF membrane and conjunctival autograft are still unclear, especially their effect on TGF-β and type 1 collagen expression. This literature review is expected to encourage and support future experimental studies about the impact of PRF and conjunctival autograft on TGF-β and type 1 collagen expression.
The bcl-2 and caspase-3 expression after purple sweet potato treatment on isoniazid and rifampicin-induced liver injury
Authors: Artini I Gusti Ayu , Astuti Ketut Widyani , Trapika I Gusti Made Gede Surya Chandra , Indrayani Agung Wiwiek 
Published: May 2024

Link of Video Abstract: https://youtu.be/9chL7pTn3bA

Backgrounds: Liver injury induced by antituberculosis drugs showed high proportions in many countries and might result in serious effects. Previous studies had proved the increase of reactive oxygen species formation and induction of apoptosis related to antituberculosis treatment. There has been no standard therapy for protecting the liver from damage related to antituberculosis. Purple sweet potato extract is one of natural sources that possess hepatoprotector action regarding its antioxidant activity. This research aimed to prove the action of purple sweet potato ethanol extract on apoptosis related to liver injury caused by antituberculosis.
Method: This research was an experimental study with randomized post-test only control group design. The samples were male rats (Rattus norvegicus) strain Wistar, age 8-12 weeks, weight 150-200 grams (divided into two groups: control and experimental group). Purple sweet potato ethanol extract was prepared with maceration technique. The measurement of bcl-2 and caspase-3 expression was conducted with ELISA method. Data analysis was performed using independent t-test.
Results: Our study result revealed that the liver expression of bcl-2 in treatment group was significantly higher than control group (15.83 ± 3.14 vs. 12.11 ± 1.53), whereas the liver expression of caspase-3 in treatment group was significantly lower than control group (1.96 ± 0.38 vs. 2.41 ± 0.30; p < 0.05).
Conclusion: Purple sweet potato extract potentially protects the liver from apoptosis induced by antituberculosis.
A rare case surgery repair for pediatric sphenoethmoidal encephalocele with single-step transfrontobasal approach
Authors: Rangkuti Dicky Lukman , Parenrengi Muhammad Arifin , Suryaningtyas Wihasto 
Published: May 2024

Link of Vidio Abstract: https://youtu.be/nsnfWQ81oRU
Background: Basal encephalocele (BEC) is the rarest type of all encephaloceles. Several methods were used to close and repair the bony defect and prevent CSF leakage. Here we present a case of a 1-month-old pediatric patient who presented with a sphenoethmoidal basal encephalocele with a single transfrontobasal approach.
Case Presentation: A female infant one-month-old with diagnosed large sphenoethmoid encephalocele (basal encephalocele). From the 3D CT scan reconstruction, we found a defect in the planum sellae and ethmoid region with a maximum line of 2.84 cm x 2.89 cm. We performed a transfrontobasal approach by using titanium mesh/plate. After follow-up, we did not find CSF leakage.
Conclusion: Uncertainty persists on the best way to restore BEC. In this instance, we used single TBF approaches to seal and repair the basal encephalocele. There are no signs of infection or CSF leakage throughout the follow-up.
Psychiatric aspects of healthcare workers during COVID-19 pandemic in Surabaya, Indonesia: prevalence of anxiety, resilience, burnout, and their correlations to stress markers
Authors: Maramis Margarita M. , Soetjipto  , Setiawati Yunias , Konginan Agustina , Muhdi Nalini , Chuanardi Winson , Ibrahim Yusuf , Malika Rosalia A. , Tang Sandra C.N. , Chandita Kadek D. , Tayibnapis Natasha A. , Hayyan Abdul J.A. , Chafid Adde M.P. , Hanindito Elizeus , Rehatta Nancy M. , Pandin Moses G.R. , Tarmono  , Tinduh Damayanti , Prakoeswa Cita R.S. , Munawaroh Fitriah 
Published: May 2024

Link of Video Abstract: https://youtu.be/nI_6kXZ0cSw

Introduction: The coronavirus disease (COVID-19) pandemic severely affected healthcare services, including causing negative impacts on healthcare workers’ mental health. An observational study was conducted at Dr. Soetomo General Hospital aimed to measure the prevalence of anxiety, resilience, burnout and their correlations to stress biomarkers amongst healthcare workers in Surabaya, Indonesia, during the COVID-19 pandemic.
Methods: Participants were residents who managed COVID-19 patients, chosen using random sampling. All participants had a 1-week shift working with COVID-19 patients in an isolation ward. The study used online questionnaires and laboratory data at the shift’s beginning and end. Along with collecting sociodemographic characteristics, State-Trait Anxiety Inventory (STAI), Brief Resiliency Scale (BRS), and Maslach Burnout Inventory (MBI) scales were administered online. At the same time, laboratory markers such as Neutrophil to lymphocyte ratio (NLR), Interleukin-6 (IL-6), cortisol, and CD4 values were studied.
Results: 61 participants were included in the study. At the beginning of the shift, 59% of participants had moderate to severe anxiety, and 83.62% had normal to high resilience. The early proportion of the participants having burnout from combined MBI measures was 88.52%. MBI-EE median scores were lower in the married group (6.50 vs. 9.50, p-value=0.030). NLR value was significantly related to STAI-S and BRS (p-value=0.007 and 0.049, respectively).
Conclusions: Most healthcare workers had anxiety and burnout, with normal levels of resilience. Our study found that NLR might be useful as a marker for anxiety and resilience.
Brunner’s gland hyperplasia as a cause of gastric outlet obstruction in a seven year old boy
Authors: Nesa Ni Nyoman Metriani , Darma Andy , Athiyyah Alpha Fardah , Ranuh IGM Reza , Sumitro Khadijah Rizky , Sudarmo Subijanto Marto 
Published: May 2024

Link of Video Abstract: https://youtu.be/9-ynkRS_wo8
Introduction: Brunner’s glands are acinotubular glands which are located mostly in the deep mucosal or submocosal layers of the proximal duodenum. Hyperplasia of these glands is reported in almost 1 in 50 upper gastrointestinal endoscopies and accounts for approximately 5 to 10 percent of all benign duodenal tumors. Brunner’s gland hyperplasia is usually asymptomatic. It can take form of polypoid or mass lesions and precipitate pyloric obstruction, gastrointestinal hemorrhage, and intussusception in children. Due to its rarity in pediatric population, it tends to be misdiagnosed.
Case Description: This case report presents a case of seven year old boy with Brunner’s gland hyperplasia presented with recurrent vomiting. A seven year-old boy was admitted to the hospital due to of worsening of intractable vomiting since five months prior to admission. He also felt abdominal discomfort, bloating, and early satiety since he was 3 years old. The patient had been treated with several medications without significant improvement. Epigastric pain was observed on abdominal palpation. Gastroscopy showed partial gastric outlet obstruction (pyloric obstruction), erosive gastritis, multiple ulcers, and erosive esophagitis. Histopatologic results from biopsy revealed chronic gastritis and positive for Helicobacter pylori. Abdominal CT scan showed protrusion solid lesion intraluminal with diameter 1.18 x 1 x 1.25 cm in part II duodenum. Patient was consulted to pediatric surgeon for laparotomy exploration and duodeno-duodenostomy. Excision of Brunner’s gland dan biopsy were performed. Surgical report showed gastric dilatation with duodenal wall hypertrophy on part I-II of duodenum. Histopathological from biopsy revealed Brunner’s gland hyperplasia with lymphoid tissue. Post surgery patient recovered well and eventually discharged without any complains. The prognosis was good.
Conclusion: Generally, Brunner’s gland hypertrophy is benign and has a good prognosis. However, with the growth of benign proliferative lesions of Brunner’s glands, mucosal ulcers may develop, thereby leading to the repair of gastric foveolar metaplasia with papillary architecture and then malignant transformation.
Diagnosis of high-grade prostate cancer in patients with unexpectedly low prostate specific antigen levels: a rare case series
Authors: Fauzan Ahmad , Djatisoesanto Wahjoe 
Published: May 2024

Link of Video Abstract: https://youtu.be/PfhZ7H4kszQ

Background: Prostate cancer is regarded as one of the most common leading causes of male cancer-related death worldwide. Clinicians agree that prostate specific antigen (PSA) is the best prostate cancer predictor. High PSA levels increase prostate cancer risk in most men. However, other research suggests that prostate cancer with low PSA levels is aggressive. In this uncommon case series, we present three high-grade prostate cancer patients with low PSA.
Case Description: Between 2018 and 2019, three patients were referred for further therapeutic management after initial evaluation and treatment from secondary hospitals. All patients underwent complete diagnostic procedures including Laboratory examination, Pathological examination, and Radiologic imaging. PSA levels were 0.67 ng/mL, 4.0 ng/ml, and 4.93 ng/mL in the first, second, and third patients, respectively. The first two of three patients had a Gleason score (GS) of 9 (5+4), and one patient presented with GS of 8 (5+3). Distant metastatic disease was not found in our series. All of the patients underwent hormonal therapy, and none of them underwent radical prostatectomy. Follow-ups were completed in all patients, with the survival of 3 months, 4 months, and 12 months respectively.
Conclusion: High-grade prostate cancer in patients with low PSA levels emphasizes the need for rigorous history taking and physical examination and quick investigation of new biomarkers and criteria for prostate cancer detection. These patients' prognosis and optimal therapy are unknown. These patients have a worse prognosis than those with high PSA values, according to multiple studies.
Diagnostic accuracy of hyponatremia as a biomarker of perforated appendicitis in pediatrics in Dr. Soetomo General Hospital, Surabaya
Authors: Rachman Bela Mayvani , Hasriastawa I Gusti Bagus Adria , Setiawan Ariandi 
Published: May 2024

Link of Video Abstract: https://youtu.be/BXu-DkOsh0k

Introduction: Acute appendicitis is the most common acute abdomen in pediatrics. The diagnosis is challenging because of the various symptoms and characteristics of children with difficulty expressing pain. This condition makes perforated appendicitis high in pediatrics. This study aimed to investigate the potential role of hyponatremia as a biochemical predictor of complicated appendicitis.
Methods: An analytical-observational study in Soetomo General Hospital was performed from 2017-2021. The natrium level of patients, particularly those under 18 years of age diagnosed with appendicitis, was examined.
Results: There were 102 pediatric patients with appendicitis. In this study, 32 subjects (31%) were diagnosed with acute appendicitis, and 70 (69%) had perforated appendicitis. It was found that there was a correlation between hyponatremia and appendicitis perforation, indicated by a sensitivity of 58.5% and specificity of 65.6%. The mean serum of natrium level in patients with perforated appendicitis, 131.1 ± 3.8 mEq/L, is lower than in patients with acute appendicitis, 136.6 ± 3.9 mEq/L. The prevalence risk value of patients diagnosed with perforated appendicitis and hyponatremia was approximately 2,69. The area under the ROC curve was 0.721, with a 95% confidence interval of 62.3% to 80.5%. With the cut-off natrium value set to ≤ 133 mEq/L, the sensitivity and specificity values were estimated at 50% and 81.25%, respectively.
Conclusions: There was a correlation between hyponatremia and appendix perforation. Hyponatremia can be potentially used as a biomarker predictor in pediatric perforated appendicitis.
Interobserver agreement and the role of smoothelin immunostain in the evaluation of Muscularis Propria (MP) invasion of Bladder Urothelial Carcinoma (BUC)
Authors: Winarti Ni Wayan , Sriwidyani Ni Putu , Maker Luh Putu Iin Indrayani , Gotra I Made , Mahastuti Ni Made , Tanaka  , Kosashi Silvia , Yudiana I Wayan 
Published: May 2024

Link of Video Abstract: https://youtu.be/KymxBUAr9eIBackground: Bladder Urothelial Carcinoma (BUC) is common cancer in the genitourinary organs. One important determinant for its therapy modality is the presence of tumor invasion into Muscularis Propria (MP). Assessing MP invasion in routine Hematoxylin-Eosin (HE) slides of Transurethral Resection of Bladder (TUR-B) specimens is not always easy due to tissue fragmentation and morphological similarities of MP to muscularis mucosa (MM) and myofibroblasts. This study was done to determine the interobserver agreement in evaluating MP invasion and to find alternatives to overcome this diagnostic problem.
Methods: This cross-sectional observational analytic study was conducted in the Pathology Laboratory of the Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G. Ngoerah Hospital, Bali, in 2022. As many as 72 HE slides of TUR-B specimens of BUC patients were examined separately by five experienced pathologists. Smoothelin immunostaining, a marker to identify MP, was also examined as a comparison. Data were processed and statistically tested using the SPSS version 20.0 program for Windows.
Results: The interobserver agreement of those five pathologists was found to be low to moderate, with an average = 0.48, ranging between 0.18-0.69. One pathologist had a low agreement with four others (<0.4) and indicated diagnostic uncertainty in 41% of the samples examined. Among four other pathologists, the agreements were moderate, with = 0.40-0.69. The proportion of concordant examination results was only 45.8%. When the outcome of each HE slide was concluded by consensus, it was found that there was no statistically significant difference with smoothelin immunostaining results.
Conclusion: Evaluation of MP invasion of BUC in TUR-B specimens had low to moderate interobserver agreement, which indicated that this examination was subjective. However, the consensus of several pathologists seems to lead to better accuracy, close to the result of smoothelin immunostaining.