bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seroepidemiological study of Q fever in domestic ruminants in semi-extensive grazing systems
Authors: Ruiz-Fons Francisco , Astobiza Ianire , Barandika Jesús F , Hurtado Ana , Atxaerandio Raquel , Juste Ramón A , García-Pérez Ana L 
Published: January 2010

AbstractBackgroundQ fever, a worldwide zoonotic disease caused byCoxiella burnetii, is endemic in northern Spain where it has been reported as responsible for large series of human pneumonia cases and domestic ruminants' reproductive disorders. To investigate pathogen exposure among domestic ruminants in semi-extensive grazing systems in northern Spain, a serosurvey was carried out in 1,379 sheep (42 flocks), 626 beef cattle (46 herds) and 115 goats (11 herds). Serum antibodies were analysed by ELISA and positive samples were retested by Complement Fixation test (CFT) to detect recent infections.ResultsELISA anti-C. burnetiiantibody prevalence was slightly higher in sheep (11.8 ± 2.0%) than in goats (8.7 ± 5.9%) and beef cattle (6.7 ± 2.0%). Herd prevalence was 74% for ovine, 45% for goat and 43% for bovine. Twenty-one percent of sheep flocks, 27% of goat and 14% of cattle herds had aC. burnetiiseroprevalence ≥ 20%. Only 15 out of 214 ELISA-positive animals reacted positive by CFT. Age-associated seroprevalence differed between ruminant species with a general increasing pattern with age. No evidence of correlation between abortion history and seroprevalence rates was observed despite the known abortifacient nature ofC. burnetiiin domestic ruminants.ConclusionsResults reported herein showed that sheep had the highest contact rate withC. burnetiiin the region but also that cattle and goats should not be neglected as part of the domestic cycle ofC. burnetii. This work reports basic epidemiologic patterns ofC. burnetiiin semi-extensive grazed domestic ruminants which, together with the relevant role ofC. burnetiias a zoonotic and abortifacient agent, makes these results to concern both Public and Animal Health Authorities.
Bortezomib With or Without Dexamethasone in Primary Systemic (Light Chain) Amyloidosis
Authors: Kastritis Efstathios , Wechalekar Ashutosh D. , Dimopoulos Meletios A. , Merlini Giampaolo , Hawkins Philip N. , Perfetti Vittorio , Gillmore Julian D. , Palladini Giovanni 
Published: January 2010

Purpose To assess the efficacy and tolerability of bortezomib with or without dexamethasone and to define prognostic factors for patients with primary systemic light chain (AL) amyloidosis treated with bortezomib or both. Patients and Methods Ninety-four patients from three centers were analyzed: 19% received the combination as first-line treatment, 81% had a median of two previous therapies, and 69% had refractory disease, while most patients had symptomatic heart involvement or elevated serum N-terminal pro-brain natriuretic peptide (NT-proBNP). Results A hematologic response was achieved in 71% within a median of 52 days, including 25% complete responses (CRs). Previously untreated patients had a 47% CR rate. Age 65 years or younger (P = .043) and twice weekly administration of bortezomib (P = .041) were associated with higher response rates. A cardiac response was documented in 29% of patients, in most as sustained improvement of functional class and less often as a decrease in wall thickness. Hematologic responses were associated with a cardiac response and NT-proBNP reduction. After a median follow-up of 12 months, 29% of patients had organ progression and 27% had hematologic progression. Median survival has not been reached and the 1-year survival rate is 76%. Baseline NT-proBNP was independently associated with survival (P = .001), while in a landmark analysis, survival was associated with NT-proBNP reduction of ≥ 30% (P = .006) and achievement of hematologic response (P = .001). Toxicity was manageable and mostly consisted of neuropathy, orthostasis, peripheral edema, and constipation or diarrhea. Conclusion Bortezomib with or without dexamethasone is active in AL amyloidosis and induces rapid responses and high rates of hematologic and organ responses. Serial measurement of cardiac biomarkers is a powerful predictor of outcome.
Association of Skeletal Muscle Wasting With Treatment With Sorafenib in Patients With Advanced Renal Cell Carcinoma: Results From a Placebo-Controlled Study
Authors: Antoun Sami , Birdsell Laura , Sawyer Michael B. , Venner Peter , Escudier Bernard , Baracos Vickie E. 
Published: January 2010

Purpose Effects of specific antineoplastic therapies on progression of cancer-associated wasting remain uncharacterized. We selected a targeted therapy, sorafenib, because of its reported association with weight loss. Patients and Methods Patients with metastatic renal cell cancer (RCC) who were resistant to standard therapy (N = 80) received sorafenib 400 mg twice daily or placebo in a randomized, double-blinded clinical trial. Computed tomography image analysis, which has high precision and specificity for evaluation of specific muscles and adipose tissues, was used to define change in total skeletal muscle and adipose tissue. Results At inclusion, 51% of patients were overweight or obese (ie, body mass index [BMI] > 25 kg/m2). Only 5% were underweight. Advanced muscle wasting (ie, sarcopenia) was present in 72% of patients with BMI less than 25 and in 34% of those with a BMI greater than 25. Patients received placebo for an average of 6 months and received sorafenib for 1 year. Patients in the placebo group had stable body weight during 6 months (0.8 kg ± 0.7 kg), with no significant alteration of muscle or fat. Patients who received sorafenib lost 2.1 kg ± 0.6 kg (P < .01) in 6 months and lost 4.2 kg ± 0.7 kg (P < .01) by 1 year. Sorafenib-treated patients lost skeletal muscle progressively at 6 months (decrease of 4.9%; P < .01) and 12 months (decrease of 8.0%; P < .01). Conclusion Sarcopenia is prevalent in patients with metastatic RCC and is an occult condition in patients with normal or high BMI. Muscle loss is specifically exacerbated by sorafenib, consistent with the evidence for a role of kinases in regulating muscle mass. Muscle loss is a sorafenib adverse effect that may relate to asthenia, fatigue, and physical disability.
Long-Term Follow-Up of Autotransplantation Trials for Multiple Myeloma: Update of Protocols Conducted by the Intergroupe Francophone du Myelome, Southwest Oncology Group, and University of Arkansas for Medical Sciences
Authors: Barlogie Bart , Attal Michel , Crowley John , van Rhee Frits , Szymonifka Jackie , Moreau Philippe , Durie Brian G.M. , Harousseau Jean-Luc 
Published: January 2010

PurposeThe purpose of this study was to update outcomes of autotransplantation trials for myeloma conducted by the Intergroupe Francophone du Myelome (IFM), the Southwest Oncology Group, and the University of Arkansas for Medical Sciences (Total Therapy [TT]).MethodsIFM90 (N = 194), IFM04 (N = 402), IFM9902 (N = 692), IFM9904 (N = 197), S9321 (N = 817), TT1 (N = 231), TT2 (N = 668), and TT3 (N = 303) were updated, and results were compared with original reports.ResultsSuperior survival with single transplantation versus standard therapy in IFM90 was confirmed (P = .004), and a trend in favor of tandem versus single transplantation was maintained in IFM94 (P = .08). S9321 data were validated, with comparable survival in single transplantation and standard treatment arms (P = .35). A survival benefit from thalidomide maintenance in IFM9902 was not confirmed (P = .39) but emerged for the thalidomide arm of TT2 (P = .04). On multivariate analysis, survival was superior in TT2, TT3, and IFM9902 (all P < .001); tandem transplantations were superior to both single transplantations and standard therapies (P < .001), as were tandem transplantations with added thalidomide versus trials without thalidomide (P < .001). Postrelapse survival (PRS) was superior when initial event-free survival (EFS) exceeded 1280 days and when tandem transplantations had been administered, whereas PRS was shorter when EFS lasted 803 days or less and when trials had included thalidomide and bortezomib.ConclusionThese long-term follow-up data of transplantation trials provide a crucial framework of reference for outcome reporting of novel agent–based trials reportedly exhibiting remarkable short-term efficacy approaching high-dose therapy results.
Case Study of Multistage Isolating Stimulation in High Temperature Deep Carbonate Horizontal Wells
Authors: Li Yongping , Wang Yonghui , Cheng Xingsheng , Che Mingguang , Zhang Fuxiang , Peng Jianxin , Zhu Raoyun 
Published: January 2010

Abstract
TZ-I carbonate reservoir in the Tarim Basin, Western China is deep buried (&gt;5000m), high temperature (&gt;130°C), low-permeability, and severely inhomogeneous, and the natural fractures, vug and huge cavity often densely distributed in it. Because the aquifer energy is poor, horizontal wells can be adopted as recovery method to expose the area of reservoir as much as possible and connect more naturally fractured formation. But the open-hole interval is too long to be effectively stimulated by un-isolated general stimulation, so the multistage isolation fracturing technique should be conducted to exert the advantage of horizontal well and maximize single-well productivity. A novel one-trip open-hole completion and stimulation system was implemented successfully to isolate the long horizontal interval with multistage packers and sliding sleeve. During the process of treatment, the characterization of opening sliding sleeve is clear, moreover, the ISIP and pressure decline after shut-in is different between every stimulation interval, which shows the system is able to effectively isolate and stimulate specified intervals. The wells productivity increased dramatically after the multistage isolation stimulation, and much higher than the vertical well or general acid fractured horizontal well in the same trap. This shows the horizontal isolating stimulation technique can enhance production and reduce rig time significantly.
ESP Application to De-bottleneck Gas Lift System Offshore
Authors: Shnaib Fathi , Nadar Manickam S. , Booth Steve , Otubaga Ademola 
Published: January 2010

AbstractThe Falah field offshore Dubai consists of four satellite platforms and is mostly produced by gas lift. High pressure lift gas is received from the main SWFateh field and the produced fluid and gas after a two-phase separation are returned to SWFateh through long sub-sea pipelines. The system is constrained both on the gas lift supply and surface production networks. The conversion of two of the major gas lift producers to electric submersible pump (ESP) has helped de-bottleneck the Falah system.The main objectives were to increase drawdown in these wells using ESP and to reduce the load on the gas lift and production systems. Both of these objectives have been successfully achieved. This paper will describe the system constraints, the options considered and the economics associated with each option. The modeling work that helped the justification for the ESP installation will also be described.The selection of well candidates was an important criterion for success. From a reservoir perspective the goal was to achieve improved oil recovery with increased drawdown. From a facility perspective the wells were selected at the farthest (FB) platform that had the minimum gas lift pressure in the field. Commissioning of the ESPs has reduced the gas load on the system and the production system pressures have decreased as a result. Gas lift operating depths would be deepened in some of the Falah wells, taking advantage of the increased gas lift header pressure now available.The use of ESP for de-bottlenecking a gas lifted field is an excellent example of production system optimization. This demonstrates how a different type of artificial lift can be effectively used to improve the productivity of a field that uses one type of artificial lift.
Rapid Assessment of Petroleum Potential of Bantumilli Marginal Oil Field by Using Infrasonic Passive Differential Spectrascopy (IPDS), an Indian Scenario
Authors: Rode E.D.. D. , Das S.R.. R. , Ravindran S.. , Mukherjee M.K.. K. , Bordoloi Amborish , Jinagam Pydiraju 
Published: January 2010

Abstract
Bantumilli oil field is located in the Krishna - Godavari Basin, in the east coast of India. The field is considered marginal. Quantifying potential in marginal fields involves several challenges like heterogeneous reservoir quality, incomplete reservoir data, production and completion practices. Perhaps the most effective way to establish potential is to conduct a detailed integrated reservoir study, which is often time consuming, expensive and applicable to fields with existing flowing wells. Hence, there is a need for rapid turn around methods that characterize and predict actual volume of oil. Infrasonic Passive Differential Spectroscopy (IPDS) is one such technology that quantifies the hydrocarbon content in a field.
The omni present infrasonic passive sound of the earth, transmitted through a reservoir containing differential media i.e., oil, gas and water, produces unique spectral signatures in the frequency range of 0 to 6 Hz. These signatures are used as direct hydrocarbon indicators. Bantumilli field contains hydrocarbons in multiple reservoirs. These reservoirs are thin and sporadic; their petrophysical characters vary conspicuously from one location to the other, do not indicate any specific trend and are not discernible in the seismic sections. IPDS technology was considered the apt solution as it would indicate the presence or absence of hydrocarbon accumulations in the combination traps of structure and stratigraphy. IPDS was executed for delineation of the oil field.
Measurements conducted after calibration of the existing wells, resulted in the identification of prospects. Additionally, IPDS reaffirmed the faults, earlier envisaged from the seismic data. The potential of the field was established through IPDS survey.
Application of the IPDS technology in marginal fields and by-passed oil in brown fields is significant as it eliminates the risk of drilling dry holes.
Practical Application of Flow Assurance and Production Chemistry Test Results
Authors: Robertson C.A. , Liem D.T. , Singh Probjot , Thomason W.H. 
Published: January 2010

Abstract
This paper describes the flow assurance and production chemistry test program implemented during the exploration and appraisal (E&A) phase of a new development area offshore Vietnam. The impact of the program on the facility design is described and program results are compared to operating experience. Fluid samples from several E&A wells were sent to the ConocoPhillips Production Assurance Technology Group in Bartlesville, Oklahoma for analysis. The analytical program consisted of the following groups of tests:
General Properties: API gravity, sulfur content and total acid number (TAN). Separation Properties: Emulsion and foaming characteristics and asphaltene deposition tendencies Flow Assurance: Viscosity, pour point, paraffin content/distribution, wax appearance temperature (WAT), wax deposition rate and gel strength.
The flow assurance test results had several positive impacts on facility and infrastructure design. Coordination between the Project Team, Operations and the Production Assurance Technology group led to significant insights which improved the facility design and operating procedures.
Rheological Properties of Polymer-Based In-Situ Gelled Acids: Experimental and Theoretical Studies
Authors: Gomaa A. M. , Nasr-El-Din H. A. 
Published: January 2010

Abstract
Polymer-based in-situ gelled acids have been used in the field for more than a decade. These acids are typically used for matrix applications at HCl concentrations of 3-5 wt%. Recent lab work and field data indicated that these acids are not fully understood, and that there is a need to better characterize and understand how these acid systems develop viscosity in-situ. This understanding will enhance the way these acids are used in the field. Therefore, the objective of this study is to determine the elastic and viscous properties of these acids as they react with the rock.
Experimental studies were conducted to measure the rheological properties for in-situ gelled acids using an oscillatory rheometer. To the best of our knowledge, this is the first time that the elastic properties were measured for these acid systems. Measuring the elastic modulus (G’) and viscous modulus (G") were done using two techniques: Dynamic sweep and Creep tests.
Based on experimental results obtained, two regimes were identified: a pure viscous behavior and a semisolid elastic behavior. A viscous regime was noted below pH 2 where G" was dominant. Yield stress, Young's modulus, G’, and G" values were relatively small in the viscous regime. A semisolid elastic behavior was observed at pH greater than 2. Yield stress, Young's modulus, G’, and G" significantly increased at pH 2, and reached their maximum values at pH 3.2. G’ increased by 3 orders of magnitude while G" increased only by an order of magnitude during acid reaction with carbonate rock.
Maxwell and Kelvin-Voigt models were able to predict the experimental data for the viscous regime only. However, for the semisolid elastic regime, these models didn't accurately predict experimental results. Three-parameter model was able to predict the semisolid elastic regime only. Therefore, a new model was developed to predict the rheological properties of these acids over a wide range of pH values. Model predictions were in good agreement with experimental results.
An Anisotropy Study: Integrated Interpretation of Shear Wave and Resistivity Anisotropy in an Offshore Field in India
Authors: Manescu A. , Tang X. , O'Sullivan T. , Pandian S. S. 
Published: January 2010

Abstract
Efficient development and production of hydrocarbon reservoirs depends on the accuracy of the geological and petrophysical models. Historically, these were all basic isotropic models where formation properties do not change with direction. With the recent advancement of measurement technology and processing technqiques, the models started incorporating and integrating variations of petrophysical properties with orientation: anisotropy. Anisotropic petrophysical properties include permeability, acoustic slowness, resistivity, etc. Complex models incorporating variations of petrophysical properties with orientation (anisotropy) are useful for well design and well placement for optimum reservoir drainage, borehole instability and sand production prediction, hydraulic fracturing, surface seismic migration or amplitude-versus-offset studies.
Cairn Energy India Pty. Ltd. recorded acoustic and resistivity anisotropy measurements in several of their offshore wells. Acoustic data was processed for azimuthal anisotropy estimation and resistivity data was processed for formation dip, azimuth, horizontal and vertical resistivity.
Whilst resistivity information has been used for accurate hydrocarbon saturation computation, the continuous dip and azimuth results provided a geological framework that was used for interpretation of acoustic azimuthal anisotropy results.
Integrating both datasets resolved potentially ambiguous interpretation of the azimuthal acoustic anisotropy source. We were able to determine the anisotropy cause (unbalanced stresses in the formation, dipping fracture/faults, highly dipping beds, and shale transverse isotropy with a vertical axis of symmetry [TIV] anisotropy).
This presentation shows how an integration of acoustic anisotropy results with resistivity anisotropy results can provide essential information for interpreting and resolving ambiguous causes of acoustic azimuthal anisotropy. This information could be used for avoiding mistakes in well placement and design, reducing sand production and avoiding borehole instability, for well completion planning and several other applications during the life of the field.
Horizontal Underbalanced Drilling Technology Successfully Applied in Sarir C- Main Field - Libya: Case Study
Authors: Qutob Hani , Ben Shatwan Mohamed , Vieira Paco 
Published: January 2010

Abstract
Recently, underbalanced drilling (UBD) has been used with increasing frequency to minimize problems associated with invasive formation damage which often greatly reduces the productivity of oil and gas reservoirs. When properly designed and executed, the benefits of underbalanced drilling (UBD) are well recognized by the industry and there is increasing raise in interest in this technology. The benefits from UBD generally fall into two categories:
Cost reduction- including mitigation of conventional drilling problems such as lost circulation, differential sticking, reduction in stimulation and cleanup costs, etc.
Value adding- including productivity improvement, increase in ultimate recovery, and real-time reservoir characterization while drilling.
Arabian Gulf oil Company (AGOCO), a major energy player in the Libyan oil industry, decided to pioneer the introduction of the new technology by embarking on a pilot project to drill 6 underbalanced horizontal wells in the Sarir C-Main field. Sarir C-Main Field is located in the Libyan Desert on the south east of Sirte basin. The reservoir consists of sandstone from the Early Cretaceous age. The field was first put on production in 1967. Since 1991 ESP pumps have been used for the production. The target reservoir, Member 5AC, is partly depleted oil bearing reservoir from the initial reservoir pressure of 3995 psi to about 2400 psi (5.3 ppg EMW). 3 out of the 6 well UBD campaign in the Sarir C have been drilled so far. The first two wells identified the technology as an effective method to improve penetration and production rates. The third well built on the experience of the previous wells by emphasizing on minimizing formation damage and maximizing the production of the well. Another objective was the evaluation of production while the well is being drilled, eliminating the need for expensive post drilling production testing.
This paper discusses the objectives, planning, problems encountered and lessons learned during the first application of UBD in the Sarir C Main Field for AGOCO Libya.
New Correlation for Z-Factor using Genetic Programming Technique
Authors: Al-Anazi B. D. , AlQuraishi A. A. 
Published: January 2010

Abstract
Compressibility factor is a measure of the deviation of a real gas from ideal behavior. Accurate information of z-factor values is necessary in engineering applications such as gas metering, pipeline design, reserves estimation, gas flow rate, and material balance calculations. In addition, z-factor is important in calculating gas properties such as gas formation volume factor, gas isothermal compressibility, viscosity, and density. The most common sources of z-factor values are experimental measurement, but if unavailable, equations of state and empirical correlations are utilized for the gas composition, and pressure and temperature conditions.
This paper presents a new model that allow accurate determination of z-factor values both for pure components and gas mixtures including significant amounts of non-hydrocarbon components and rich gas condensates at wide ranges of pressures and temperatures. Large database of experimental z-factor measurement are used. It includes more than 977 samples of worldwide sour and sweet gases. The database consists of gas composition, and z-factor experimental measurements at different pseudo-reduced properties of pressures and temperatures. The new model was developed and tested using linear genetic programming (GP) technique. The proposed model efficiency was compared to four commonly used equations of state (Van der-Walls, Redlech kwong, Peng-Robinson and Lawel-Lake-silberberg) in addition to six empirical correlations (Dranchuk-Purvis-Robinson, Dranchuk-Abu-Kassem, Hall-Yarborough, and Beggs and Brill). Several criteria are used to evaluate the proposed model including the average relative error (ARE), average absolute relative error (AARE), standard deviation (SD), and cross plots. The output of this work indicates the strength of the linear genetic programming technique and the good accuracy and simplicity of the developed model in comparison to the tested commonly utilized models.