bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colic in competing endurance horses presenting to referral centres: 36 cases
Authors: FIELDING C. L. , DECHANT J. E. 
Published: November 2011

SummaryReasons for performing study:Colic is a common reason for elimination from equine endurance competitions and has recently been identified as the leading cause of mortality in this group of horses. Hydration and electrolyte derangements are often severe, but are probably related to endurance exercise and not necessarily the episode of colic. Better understanding of the causes of colic and the expected outcome is needed to guide treatment decisions in endurance horses.Objectives:To describe the history, case details, clinical examination, laboratory, treatment and outcomes for horses presenting to equine referral centres for treatment of colic associated with endurance competition and to identify variables associated with prolonged hospitalisation.Methods:Thirty‐six horses from 2 equine referral centres were included in the analysis. In addition to descriptive statistics, Cox proportional hazards models were used to evaluate factors associated with length of hospitalisation.Results:A diagnosis of open or ileus was made in the majority of horses (56%). Salmonellosis and enteritis (Salmonellanegative) were also recognised (16%). Exploratory abdominal surgery was performed in 5 of the horses. Only one of 36 horses did not survive to discharge. Previous eliminations from competition (negative association) and total i.v. fluids within the first 24 h (positive association) of admission were both associated with length of hospitalisation.Conclusions:Endurance horses with colic typically respond to medical treatment but in some cases hospitalisation may be prolonged. The role ofSalmonellainfections in endurance horses with colic requires further research.Potential relevance:Despite potentially severe clinical and laboratory derangements, equine practitioners should make owners aware that the prognosis for competing endurance horses with colic is good when treated appropriately.
Effect of rating scales on scores given to junior doctors in multi-source feedback
Authors: Hassell Andrew , Bullock Alison , Whitehouse Andrew , Wood Lawrence , Jones Peter , Wall David 
Published: November 2011

Abstract

Background
Multi-source feedback (MSF) has an established role in the workplace based assessment of doctors in training. Different models of MSF are currently used in different training programmes and settings. One important way in which these models differ is the rating scale on which assessors score the trainee. The aim of this study was to explore the effect of rating scale on MSF scores.

Methods
Foundation Year 2 trainees in hospitals in the West Midlands underwent MSF using the validated MSF tool, team assessment of behaviour (TAB) in autumn 2005. Trainees were scored with TAB using one of four different rating scales, ranging from 3- to 9-point scales. Each participating hospital used only one rating scale. The proportions of trainees scored as having potential problems were related to the different rating scale used. Similarly, the proportions scored as ‘above expectations’ were compared. Assessors also completed a short questionnaire regarding the assessment.

Results
245 trainees underwent 2594 assessments. Longer rating scales were associated with a lower proportion of trainees awarded ‘problem’ scores and higher proportions of trainees scored as ‘above expectations’. Assessors generally reported no difficulties whichever rating scale they had used.

Conclusion
Careful consideration, recognising its potential impact on assessment score, should be given to the rating scale used when instituting MSF within a system of workplace based assessment.
Primary IgA nephropathy in north India: is it different?
Authors: Mittal Neha , Joshi Kusum , Rane Swapnil , Nada Ritambhra , Sakhuja Vinay 
Published: November 2011

AbstractBackgroundImmunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide, but has a variable geographic distribution. The bulk of the disease burden is borne by Asian countries. However, its exact prevalence or clinicopathologic spectrum in India is not well documented.MethodsThis cross sectional study analysed the renal biopsy findings and clinical features at presentation in 66 patients of primary IgA nephropathy diagnosed over a period of 2 years (2007–2008). The results were compared with studies from other centres in the country and elsewhere.ResultsIgA nephropathy comprised 8.1% of all native kidney biopsies. The mean age of the patients was 29.9 years with a male:female ratio of 4.4:1. Most patients presented with renal failure and a significant percentage (23%) also had nephrotic range proteinuria. Renal biopsies were classified by the Haas classification and were further scored by the MEST scoring system of the Oxford classification. By Haas classification, 41 cases (62%) showed advanced sclerotic lesions of class V. Active crescents (cellular or fibrocellular) were seen in 42% of cases, and 26% of cases showed endocapillary proliferation. Serum creatinine values were highest in the presence of proliferative lesions. MEST scoring of the Oxford classification was not applicable in approximately 18% of cases because of the presence of advanced sclerotic lesions. On immunofluorescence, the majority of the cases showed both mesangial and membranous positivity for IgA antisera. Electron microscopy revealed para-mesangial location of immune complex deposition in the majority of the cases. It also showed glomerular basement membrane abnormalities in two cases.ConclusionComparison of clinical and pathological features revealed that this disease presents as an advanced disease in much younger individuals in this study compared to other studies. Elucidation of the underlying factors may have immense therapeutic implications.
Expression of autophagy-related genes in the anterior silk gland of the silkworm (Bombyx mori) during metamorphosis
Authors: Li Qingrong , Deng Xiaojuan , Huang Zhijun , Zheng Sichun , Tettamanti Gianluca , Cao Yang , Feng Qili 
Published: November 2011

Programmed cell death (PCD) is a genetically regulated process of cell elimination and is evolutionarily conserved in eukaryotes. Degeneration of larval tissues during metamorphosis in insects is a result of PCD triggered by ecdysteroids and autophagic process has been shown to be involved in the degeneration of silk gland of the silkworm ( Bombyx mori L., 1758). However, experimental evidence for the expression of autophagy marker genes remains insufficient. In this study, expression of the autophagy-related genes BmAtg5, BmAtg6, BmAtg8, and BmAtg12 was determined in the anterior silk glands of larvae and pupae during larval to pupal transformation by using reverse-transcription PCR, quantitative real-time PCR, and Western blot analyses. The results indicated that BmAtg5, BmAtg6, BmAtg8, and BmAtg12 had the highest expression levels on the 3rd day of the wandering stage or at the prepupal stage, and the time frame of the expression of these genes was coincident with the morphological characteristics of autophagy in the silk gland during the larval to pupal transformation. This study demonstrated that the autophagy-related genes are involved in the degeneration of the anterior silk gland of B. mori.
Drifting away: implications of changes in ice conditions for a pack-ice-breeding phocid, the harp seal (Pagophilus groenlandicus)
Authors: Bajzak C.E. , Hammill M.O. , Stenson G.B. , Prinsenberg S. 
Published: November 2011

Harp seals ( Pagophilus groenlandicus (Erxleben, 1777)) required drifting pack-ice for birth, nursing, and as a resting platform for neonates after weaning. Data on the yearly location of whelping patches in the Gulf of St. Lawrence collected between 1977 and 2011 were combined with ice cover data (thickness and duration) to examine whether female harp seals actively select particular ice features as a breeding platform and to describe how these ice features have varied over the last 40 years at three spatial scales: the entire Gulf of St. Lawrence, the southern gulf, and the “traditional whelping area” within the southern Gulf. From our analyses, harp seals prefer the thickest ice stages available in the Gulf: grey–white and first-year ice. Lower than normal ice coverage years were more frequent for the required grey–white and first-year ice than for the total ice cover and less frequent at the “traditional whelping area” scale close to the northwestern coast of the Magdalen Islands than at the Gulf of St. Lawrence scale. The frequency of light ice years increased and the duration of the ice season decreased throughout the last decade. Our study showed that the temporal availability and the spatial distribution of the suitable ice are important when evaluating the effect of changes in ice conditions rather than overall ice extent.
CXCR4 Activation Defines a New Subgroup of Sonic Hedgehog–Driven Medulloblastoma
Authors: Sengupta Rajarshi , Dubuc Adrian , Ward Stacey , Yang Lihua , Northcott Paul , Woerner B. Mark , Kroll Kirsten , Luo Jingqin , Taylor Michael D. , Wechsler-Reya Robert J. , Rubin Joshua B. 
Published: November 2011

Abstract
Medulloblastoma prognosis tends to be poor, despite aggressive therapy, but defining molecular subgroups may identify patients who could benefit from targeted therapies. This study used human gene array and associated clinical data to identify a new molecular subgroup of medulloblastoma characterized by coactivation of the Sonic hedgehog (SHH) and CXCR4 pathways. SHH–CXCR4 tumors were more common in the youngest patients where they were associated with desmoplastic histology. In contrast to tumors activating SHH but not CXCR4, coactivated tumors exhibited greater expression of Math1 and cyclin D1. Treatment with the CXCR4 antagonist AMD3100 inhibited cyclin D1 expression and maximal tumor growth in vivo. Mechanistic investigations revealed that SHH activation stimulated CXCR4 cell surface localization and effector signaling activity, whereas SHH absence caused CXCR4 to assume an intracellular localization. Taken together, our findings define a new medulloblastoma subgroup characterized by a functional interaction between the SHH and CXCR4 pathways, and they provide a rationale to clinically evaluate combined inhibition of SHH and CXCR4 for medulloblastoma treatment. Cancer Res; 72(1); 122–32. ©2011 AACR.
5-Hydroxymethylcytosine Is Strongly Depleted in Human Cancers but Its Levels Do Not Correlate with IDH1 Mutations
Authors: Jin Seung-Gi , Jiang Yong , Qiu Runxiang , Rauch Tibor A. , Wang Yinsheng , Schackert Gabriele , Krex Dietmar , Lu Qiang , Pfeifer Gerd P. 
Published: November 2011

Abstract
The base 5-hydroxymethylcytosine (5hmC) was recently identified as an oxidation product of 5-methylcytosine in mammalian DNA. Here, using sensitive and quantitative methods to assess levels of 5-hydroxymethyl-2′-deoxycytidine (5hmdC) and 5-methyl-2′-deoxycytidine (5mdC) in genomic DNA, we investigated whether levels of 5hmC can distinguish normal tissue from tumor tissue. In squamous cell lung cancers, levels of 5hmdC were depleted substantially with up to 5-fold reduction compared with normal lung tissue. In brain tumors, 5hmdC showed an even more drastic reduction with levels up to more than 30-fold lower than in normal brain, but 5hmdC levels were independent of mutations in isocitrate dehydrogenase-1. Furthermore, immunohistochemical analysis indicated that 5hmC is remarkably depleted in many types of human cancer. Importantly, an inverse relationship between 5hmC levels and cell proliferation was observed with lack of 5hmC in proliferating cells. The data therefore suggest that 5hmdC is strongly depleted in human malignant tumors, a finding that adds another layer of complexity to the aberrant epigenome found in cancer tissue. In addition, a lack of 5hmC may become a useful biomarker for cancer diagnosis. Cancer Res; 71(24); 7360–5. ©2011 AACR.
Sorcin Induces a Drug-Resistant Phenotype in Human Colorectal Cancer by Modulating Ca2+ Homeostasis
Authors: Maddalena Francesca , Laudiero Gabriella , Piscazzi Annamaria , Secondo Agnese , Scorziello Antonella , Lombardi Valentina , Matassa Danilo Swann , Fersini Alberto , Neri Vincenzo , Esposito Franca , Landriscina Matteo 
Published: November 2011

Abstract
The Ca2+-binding protein sorcin regulates intracellular calcium homeostasis and plays a role in the induction of drug resistance in human cancers. Recently, an 18 kDa mitochondrial isoform of sorcin was reported to participate in antiapoptosis in human colorectal cancer (CRC), but information remains lacking about the functional role of the more abundant 22 kDa isoform of sorcin expressed in CRC. We found the 22 kDa isoform to be widely expressed in human CRC cells, whether or not they were drug resistant. Its upregulation in drug-sensitive cells induced resistance to 5-fluorouracil, oxaliplatin, and irinotecan, whereas its downregulation sensitized CRC cells to these chemotherapeutic agents. Sorcin enhances the accumulation of Ca2+ in the endoplasmic reticulum (ER), preventing ER stress, and, in support of this function, we found that the 22 kDa isoform of sorcin was upregulated under conditions of ER stress. In contrast, RNAi-mediated silencing of sorcin activated caspase-3, caspase-12, and GRP78/BiP, triggering apoptosis through the mitochondrial pathway. Our findings establish that CRC cells overexpress sorcin as an adaptive mechanism to prevent ER stress and escape apoptosis triggered by chemotherapeutic agents, prompting its further investigation as a novel molecular target to overcome MDR. Cancer Res; 71(24); 7659–69. ©2011 AACR.
Iron Deprivation Suppresses Hepatocellular Carcinoma Growth in Experimental Studies
Authors: Ba Qian , Hao Miao , Huang He , Hou Junmei , Ge Shichao , Zhang Zhuzhen , Yin Jun , Chu Ruiai , Jiang Hualiang , Wang Fudi , Chen Kaixian , Liu Hong , Wang Hui 
Published: November 2011

Abstract
Purpose: Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death, and iron overload is a significant risk factor in the development of HCC. In this study, we investigated the potential application of depriving iron by a novel iron chelator, thiosemicarbazone-24 (TSC24), in HCC treatment.
Experimental Design: Two HCC cell lines and HFE knockout (HFE−/−) mice were used to determine iron chelation efficiency of TSC24. The anticancer effects of TSC24 on HCC were analyzed in vitro and in athymic xenograft mouse models.
Results: Treatment with TSC24 significantly decreased the cellular iron concentration in hepatoma cells and the serum iron concentration in HFE−/− mice by blocking iron uptake and interfering with normal regulation of iron levels. Moreover, the viability of HCC cell lines was reduced by TSC24. Confirming the mechanism of the agent, this decrease in viability could be partially rescued by addition of exogenous iron. TSC24 also suppressed tumor growth in athymic mice bearing human HCC xenografts in a concentration-dependent manner, without apparent toxicity in parallel with a decrease in the serum iron level. Further studies revealed that TSC24 efficiently triggered cell-cycle arrest and apoptosis in Hep3B and HepG2 cell lines.
Conclusions: TSC24 is a potent iron chelator that suppresses human HCC tumor growth by disrupting iron homeostasis, reducing available iron, and triggering cell-cycle arrest and apoptosis, without apparent host toxicity at effective doses. Thus, TSC24 shows great potential for the treatment of HCC. Clin Cancer Res; 17(24); 7625–33. ©2011 AACR.
Smoking Cessation 1 Year Poststroke and Damage to the Insular Cortex
Authors: Suñer-Soler Rosa , Grau Armando , Gras Maria Eugenia , Font-Mayolas Sílvia , Silva Yolanda , Dávalos Antonio , Cruz Verónica , Rodrigo Joana , Serena Joaquín 
Published: November 2011

Background and Purpose—
Hospitalization as a result of stroke provides an opportunity to stop smoking that is often not taken up. The present study analyzes sociodemographic, psychological, and lesion-related variables to identify associated factors for smoking cessation during the first year after stroke.

Methods—
We conducted a prospective longitudinal study with a 1-year follow-up of a cohort of 110 patients with acute stroke who were smokers at the time of diagnosis and were admitted consecutively between January 2005 and July 2007.

Results—

On hospital release, 69.1% had given up smoking but at 1 year, only 40% had stopped smoking. Of the 110 patients, 27 (24.5%) had an acute stroke lesion in the insular cortex, of which 19 (70.3%) were nonsmokers at 1 year. Strongly associated factors in giving up smoking were the location of the lesion in the insular cortex (OR, 5.42; 95% CI, 1.95–15.01;
P
=0.001) and having the intention of giving up before the stroke, comparing precontemplating patients (without intention of giving up in the near future) with contemplating and prepared patients (intention of stopping in the near future; OR, 7.29; 95% CI, 1.89–28.07;
P
=0.004).

Conclusions—
Of patients with stroke who were smokers, only 4 of 10 patients had stopped smoking 1 year after admission. Our results show that the variables best predicting smoking cessation in patients with a stroke diagnosis 1 year after hospital discharge are insular damage and the prestroke intention to stop.
National Mosaic and Multi-Sensor QPE (NMQ) System: Description, Results, and Future Plans
Authors: Zhang Jian , Howard Kenneth , Langston Carrie , Vasiloff Steve , Kaney Brian , Arthur Ami , Van Cooten Suzanne , Kelleher Kevin , Kitzmiller David , Ding Feng , Seo Dong-Jun , Wells Ernie , Dempsey Chuck 
Published: November 2011

The National Mosaic and Multi-sensor QPE (Quantitative Precipitation Estimation), or “NMQ”, system was initially developed from a joint initiative between the National Oceanic and Atmospheric Administration's National Severe Storms Laboratory, the Federal Aviation Administration's Aviation Weather Research Program, and the Salt River Project. Further development has continued with additional support from the National Weather Service (NWS) Office of Hydrologic Development, the NWS Office of Climate, Water, and Weather Services, and the Central Weather Bureau of Taiwan. The objectives of NMQ research and development (R&D) are 1) to develop a hydrometeorological platform for assimilating different observational networks toward creating high spatial and temporal resolution multisensor QPEs for f lood warnings and water resource management and 2) to develop a seamless high-resolution national 3D grid of radar reflectivity for severe weather detection, data assimilation, numerical weather prediction model verification, and aviation product development.
Through about ten years of R&D, a real-time NMQ system has been implemented (http://nmq.ou.edu). Since June 2006, the system has been generating high-resolution 3D reflectivity mosaic grids (31 vertical levels) and a suite of severe weather and QPE products in real-time for the conterminous United States at a 1-km horizontal resolution and 2.5 minute update cycle. The experimental products are provided in real-time to end users ranging from government agencies, universities, research institutes, and the private sector and have been utilized in various meteorological, aviation, and hydrological applications. Further, a number of operational QPE products generated from different sensors (radar, gauge, satellite) and by human experts are ingested in the NMQ system and the experimental products are evaluated against the operational products as well as independent gauge observations in real time.
The NMQ is a fully automated system. It facilitates systematic evaluations and advances of hydrometeorological sciences and technologies in a real-time environment and serves as a test bed for rapid science-to-operation infusions. This paper describes scientific components of the NMQ system and presents initial evaluation results and future development plans of the system.
(Re) Considering Cattle Farming in Southern Africa under a Changing Climate
Authors: Archer van Garderen E. R. M. 
Published: November 2011

AbstractScientists in southern Africa and elsewhere focusing on climate change and agriculture are increasingly demonstrating how livestock, as a highly climate sensitive sector, may be affected by climate change. The Fourth Assessment Report (AR4) of the Intergovernmental Panel on Climate Change (IPCC) observes, for example, that “Projected increased temperature, combined with reduced precipitation in some regions (e.g., Southern Africa) would lead to increased loss of domestic herbivores during extreme events in drought-prone areas” (Easterling et al.). Response and policy discussions around climate change and agriculture in the Southern African Development Community (SADC) region have, however, thus far tended to focus far more on staple crops. The latest projected future temperatures for southern Africa show a clear increase across most models. Further, temperatures in exceedance of tested livestock comfort thresholds are indicated for the future, particularly for those months of most concern to cattle farmers. Enabling adaptation in the livestock sector should thus be a significant focus of a country’s response to climate change, particularly in countries where the livestock sector is a critical component of the formal and informal economy. Although innovations are often a primary component of livestock adaptation plans under design, it is now recognized that longstanding approaches to the management of livestock may well have valuable lessons for future adaptation. Such approaches include the reintroduction of genetically diverse and resilient breeds, as well as increased support and incentives for those farmers planning and undertaking such approaches.
Gender differences in the psychological impact of tsunami
Authors: Viswanath Biju , Maroky Ami S. , Math Suresh B. , John John P. , Cherian Anish V. , Girimaji Satish C. , Benegal Vivek , Hamza Ameer , Chaturvedi Santosh K. 
Published: November 2011

Aim: The aim of this observational study was to explore gender-related differences in psychiatric morbidity during the initial three months following the December 2004 earthquake and tsunami involving the Andaman and Nicobar Islands, India. Methods: There were 12,784 survivors sheltered across 74 relief camps with 4,684 displaced survivors in Port Blair and 8,100 non-displaced survivors in Car-Nicobar Island. All persons who accessed mental health assistance within the camps constituted the study sample. Diagnoses were made by qualified psychiatrists using the ICD-10. There were 475 patients: 188 (40%) men and 287 (60%) women. Results: There were significant gender differences in terms of displacement. There were significantly higher levels of panic disorder, unspecified anxiety disorder and somatic complaints in the displaced women while the non-displaced population showed more adjustment disorder. Conclusions: Displacement was a significant factor in the manifestations of observed pathology. Displaced women had greater psychiatric morbidity. In addition, the fact that adjustment disorder (a self-limiting disorder form of psychopathology) was more prevalent in the non-displaced group may be a reflection of the findings of overall lesser morbidity in non-displaced women. Hence, women may have to be rehabilitated in their own habitats after major disasters.