bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updated chronology for Peoria Silt (loess) accumulation in Illinois and western Indiana from radiocarbon dating of terrestrial gastropod shells
Authors: Grimley David A. , Loope Henry M. , Jacobs Peter M. , Nash T. Andrew , Dendy Sarah N. , Conroy Jessica L. , Curry B. Brandon 
Published: May 2024

AbstractBased on calibrated radiocarbon ages of terrestrial gastropod shells (Succineidae,Discus,Stenotrema,Webbhelix), the chronology of Peoria Silt (loess) deposition in the Central Lowlands is updated. These taxa provide reliable ages (within ~0.2 ka), based on historical shell dating, shell-organic age comparisons, and stratigraphic consistency. A compilation of 53 new and 36 published Peoria Silt shell ages (calibrated), from 12 localities, date from 30.0 to 17.4 ka. Proximal (fossiliferous) loess from 10 sections had mean loess accumulation rates of 0.6–2.2 mm/yr. Study sites along the upper Mississippi, Illinois, to mid-Mississippi, and Ohio-Wabash Valleys suggest Peoria loess accumulated from ~27 to 15 ka, ~29 to 18 ka, and ~30 to 18 ka, respectively. The cessation age for Peoria Silt, based on surface extrapolations, is ~1–6 ka earlier than some prior Illinois estimates, even assuming slower loess accumulation in the modern solum. Younger loess in northwestern Illinois likely reflects, in part, Superior and Des Moines Lobe glacial-meltwater sediment, and Iowan Erosion Surface inputs to the upper Mississippi Valley, after the Lake Michigan Lobe receded. Furthermore, stronger winds, drier conditions, and reduced vegetation cover in valley deflation areas may have favored higher accumulation rates and later loess deposition in northwestern relative to southeastern areas.
IN PURSUIT OF A TREATY'S SOUL: A STUDY OF THE OBJECT AND PURPOSE OF THE FOURTH GENEVA CONVENTION
Authors: Mačák Kubo , Policinski Ellen 
Published: May 2024

AbstractThe Geneva Convention relative to the Protection of Civilian Persons in Time of War provides a practical and effective framework for the protection of civilians in international armed conflicts that has retained its relevance for 75 years since its adoption. As with all treaties, its ‘object and purpose’ has a concrete impact on how its terms are interpreted, giving insights into the ordinary meaning of the text and allowing the aim of the Convention to be fully realized. This article asks and answers a series of questions to elucidate the role of the object and purpose in treaty interpretation and how to identify the object and purpose of a given treaty before focusing on the specificities of international humanitarian law treaties. On that basis, it determines that the overall ‘object and purpose’ of the Convention is to protect civilians during armed conflict, including in circumstances where they are subject to permissible measures of control and security. The article then demonstrates how that ‘object and purpose’ assists with the resolution of specific, well-known interpretive dilemmas including the determination of protected status under the Convention and the application of provisions premised on the existence of a Protecting Power.
Chinese Immigrant Caregivers: Understanding Their Unmet Needs and the Co-Design of an mHealth App
Authors: Yu Kexin , Jiang Haojun , Liu Mandong , Wu Shinyi , Jordan-Marsh Maryalice , Chi Iris 
Published: May 2024

AbstractBackgroundImmigrant caregivers support the aging population, yet their own needs are often neglected. Mobile technology-facilitated interventions can promote caregiver health by providing easy access to self-care materials.ObjectiveThis study employed a design thinking framework to examine Chinese immigrant caregivers’ (CICs) unmet self-care needs and co-design an app for promoting self-care with CICs.MethodsNineteen semi-structured interviews were conducted in conceptual design and prototype co-design phases.FindingsParticipants reported unmet self-care needs influenced by psychological and social barriers, immigrant status, and caregiving tasks. They expressed the need to learn to keep healthy boundaries with the care recipient and respond to emergencies. Gaining knowledge was the main benefit that drew CICs’ interest in using the self-care app. However, potential barriers to use included issues of curriculum design, technology anxiety, limited free time, and caregiving burdens.DiscussionThe co-design process appears to be beneficial in having participants voice both barriers and preferences.
A novel intelligent fault diagnosis method of bearing based on multi-head self-attention convolutional neural network
Authors: Ren Hang , Liu Shaogang , Qiu Bo , Guo Hong , Zhao Dan 
Published: May 2024

Abstract
Deep learning (DL) has been widely used in bearing fault diagnosis. In particular, convolutional neural networks (CNNs) improve diagnosis accuracy by extracting excellent fault features. However, CNN lacks an explicit learning mechanism to distinguish between different fault characteristics in the input signal to the diagnosis results. This article presents a new end-to-end depth framework called multi-head self-attention convolution neural network (MSA-CNN) for bearing fault diagnosis. Firstly, we adopt a data pre-processing method that directly converts one-dimensional (1D) original signals into two-dimensional (2D) grayscale images, which is simple to implement and preserves the complete information of the original signal. Secondly, multi-head self-attention (MSA) is first constructed to aggregate the global information and adaptively assign weights to the input signal's features. Thirdly, the CNN with small-scale kernels extracted detailed local features. Finally, the learned high-level representations are fed into the full connect (FC) layer for fault diagnosis. The performance of the MSA-CNN is validated on different datasets. The results show that the proposed MSA-CNN can significantly improve fault diagnosis accuracy compared with the other state-of-the-art methods and has excellent noise immunity performance.
Lifetime alcohol use disorder and gambling disorder: clinical profile and treatment response
Authors: Chamberlain Samuel R. , Ioannidis Konstantinos , Grant Jon E. 
Published: May 2024

AbstractObjectivesGambling disorder affects 0.5–2.4% of the population and shows strong associations with lifetime alcohol use disorder. Very little is known regarding whether lifetime alcohol use disorder can impact the clinical presentation or outcome trajectory of gambling disorder.MethodsData were pooled from previous clinical trials conducted on people with gambling disorder, none of whom had current alcohol use disorder. Demographic and clinical variables were compared between those who did versus did not have lifetime alcohol use disorder.ResultsOf the 621 participants in the clinical trials, 103 (16.6%) had a lifetime history of alcohol use disorder. History of alcohol use disorder was significantly associated with male gender (relative risk [RR] = 1.42), greater body weight (Cohen’s D = 0.27), family history of alcohol use disorder in first-degree relative(s) (RR = 1.46), occurrence of previous hospitalization due to psychiatric illness (RR = 2.68), and higher gambling-related legal problems (RR = 1.50). History of alcohol use disorder was not significantly associated with other variables that were examined, such as severity of gambling disorder or extent of functional disability. Lifetime alcohol use disorder was not significantly associated with the extent of clinical improvement in gambling disorder symptoms during the subsequent clinical trials.ConclusionsThese data highlight that lifetime alcohol use disorder is an important clinical variable to be considered when assessing gambling disorder because it is associated with several untoward features (especially gambling-related legal problems and prior psychiatric hospitalization). The study design enabled these associations to be disambiguated from current or recent alcohol use disorder.
ARCHIMEDEAN NEWFORM THEORY FOR
$\operatorname {\mathrm {GL}}_n$
Authors: Humphries Peter 
Published: May 2024

AbstractWe introduce a new invariant, the conductor exponent, of a generic irreducible Casselman–Wallach representation of
$\operatorname {\mathrm {GL}}_n(F)$
, where F is an archimedean local field, that quantifies the extent to which this representation may be ramified. We also determine a distinguished vector, the newform, occurring with multiplicity one in this representation, with the complexity of this vector measured in a natural way by the conductor exponent. Finally, we show that the newform is a test vector for
$\operatorname {\mathrm {GL}}_n \times \operatorname {\mathrm {GL}}_n$
and
$\operatorname {\mathrm {GL}}_n \times \operatorname {\mathrm {GL}}_{n - 1}$
Rankin–Selberg integrals when the second representation is unramified. This theory parallels an analogous nonarchimedean theory due to Jacquet, Piatetski-Shapiro, and Shalika; combined, this completes a global theory of newforms for automorphic representations of
$\operatorname {\mathrm {GL}}_n$
over number fields. By-products of the proofs include new proofs of Stade’s formulæ and a new resolution of the test vector problem for archimedean Godement–Jacquet zeta integrals.
Why Do CO2 Quadrupling Simulations Warm More Than Twice as Much as CO2 Doubling Simulations in CMIP6?
Authors: Poletti A. N. , Frierson D. M. W. , Armour K. C. 
Published: May 2024

AbstractWe compare abrupt CO2‐quadrupling (abrupt‐4xCO2) and ‐doubling (abrupt‐2xCO2) simulations across 10 CMIP6 models. Two models (CESM2 and MRI‐ESM2‐0) warm substantially more than twice as much under abrupt‐4xCO2 than abrupt‐2xCO2, which cannot be explained by the non‐logarithmic scaling of CO2 forcing. Using an energy balance model, we show that increased warming rates within these two models are driven by both less‐negative radiative feedbacks and smaller global effective heat capacity under abrupt‐4xCO2. These differences are caused by a decrease in low cloud cover and shallower ocean heat storage, respectively; both are linked to smaller fractional declines in the Atlantic Meridional Overturning Circulation (AMOC) under abrupt‐4xCO2 (relative to abrupt‐2xCO2). On a global scale, higher climate sensitivity under larger forcing can be explained by a feedback‐temperature dependence; however, we find that forcing‐dependent spatial warming patterns due to AMOC decline are an important physical mechanism which reduces warming in a way that is not captured by a global‐mean framework.
Unveiling the Distinct Structure of the Upper Mantle Beneath the Canary and Madeira Hotspots, as Depicted by the 660, 410, and X Discontinuities
Authors: Bonatto Luciana , Schlaphorst David , Silveira Graça , Mata João , Civiero Chiara , Piromallo Claudia , Schimmel Martin 
Published: May 2024

AbstractThe Canary and Madeira Islands are two distinct hotspots in the Central‐East Atlantic that are close to each other. Their volcanism is generally attributed to underlying mantle plumes, but the detailed structure of these plumes is still not well understood. The thermal and compositional structure of the plume introduces complexities in the phase transitions of the mantle, which impact the depth and magnitude of seismic discontinuities. We use 1,268 high‐quality receiver functions from stations located at the two hotspots to detect P‐to‐s converted phases through a common‐conversion point stacking approach and conduct a detailed analysis of mantle seismic discontinuities. The results show that both hotspots are characterized by a thin mantle transition zone (MTZ), with sharp 410 and 660 discontinuities at depths of 428–421 km and 647–664 km, beneath the Canaries and Madeira respectively. The results indicate that the Canary plume crosses the MTZ, whereas the Madeira plume mainly influences the upper portion of the MTZ. Furthermore, we find reliable detections of a sharp X discontinuity beneath the Canaries at 287 km. Its presence suggests the accumulation of silica‐rich recycled eclogite at these depths. We also use the amplitudes of P410s and PXs to derive velocity jumps at corresponding discontinuities. Based on these measurements, we estimate that the basalt proportion is 60%–80%, with accumulation being more significant in the Canaries than in Madeira. The MTZ thickness, the presence of the X discontinuity, and the high basalt proportion provide compelling evidence for a deep‐rooted thermochemical plume beneath the study area.
Simultaneously Interactions of Ultra‐Low‐Frequency Waves and Whistler Waves, and Whistler Waves and Quasi‐Electrostatic Whistler Harmonics in the Earth's Magnetosheath
Authors: Xu S. B. , Huang S. Y. , Yuan Z. G. , Jiang K. , Wu H. H. , Deng D. , Xiong Q. Y. , Lin R. T. , Wang Z. , Zhang J. 
Published: May 2024

AbstractIdentifying how different wave modes interaction with each other is an important topic in space physics. Using measurements from the Magnetospheric Multiscale (MMS) mission, we report an event in the Earth's magnetosheath where ultra‐low‐frequency (ULF) waves, whistler waves, and quasi‐electrostatic whistler harmonics were observed simultaneously. Specifically, our analyses show that the parallel components of ULF waves modulate the electron butterfly distributions which provide the free energy to the excitation of the observed whistler waves. Meanwhile, quasi‐electrostatic waves sharing frequencies that are nearly integral multiples of the frequency of the observed whistlers are identified as nonlinear harmonics of whistler waves. The close correlations between the whistler waves and the electric field harmonics, as well as the high bicoherence indexes within the frequency ranges of the whistlers and harmonics, suggest the significant nonlinear couplings between the whistler waves and quasi‐electrostatic whistler harmonics. Our work provides new insights to the interactions between waves at different frequency bands.
Point-of-care human milk concentration by passive osmosis: comprehensive analysis of fresh human milk samples
Authors: Schinkel Elizabeth R. , Nelson Elizabeth R. , Kim Jae H. , Perrin Maryanne T. , Dyer Roger , Elango Rajavel , Bode Lars , Dallas David C. , Lueangsakulthai Jiraporn , Briere Carrie-Ellen , Taylor Sarah N. 
Published: May 2024

Abstract
Objective
Preterm infants need enrichment of human milk (HM) for optimal growth. This study evaluated a novel, point-of-care human milk concentration (HMC) process for water removal from fresh HM samples by passive osmotic concentration.

Study design
Nineteen fresh HM samples were concentrated by incubation with the HMC devices for 3 h at 4 °C. Pre- and post-concentration HM samples were compared by HM properties for: pH, osmolality, macronutrients, enzyme activity, bioactive, and total cell viability.

Results
Passive osmotic concentration reduced HM volume by an average of 16.3% ± 3.8% without a significant effect on pH or cell viability. Ten of the 41 HM components did not differ significantly (p > 0.05) between pre- and post-concentration samples. Twenty-three increased within the expected range by volume reduction. Six increased more than expected, two less than expected, and none decreased significantly.

Conclusion
Passive osmotic concentration of fresh HM can concentrate HM components by selective removal of water. HM osmolality and pH remained within neonatal feeding parameters.
The association between tumour heterogeneity and immune evasion mechanisms in hepatocellular carcinoma and its clinical implications
Authors: Chen Kaina , Shuen Timothy W. H. , Chow Pierce K. H. 
Published: May 2024

AbstractHepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. The emergence of combination therapy, atezolizumab (anti-PDL1, immune checkpoint inhibitor) and bevacizumab (anti-VEGF) has revolutionised the management of HCC. Despite this breakthrough, the best overall response rate with first-line systemic therapy is only about 30%, owing to intra-tumoural heterogeneity, complex tumour microenvironment and the lack of predictive biomarkers. Many groups have attempted to classify HCC based on the immune microenvironment and have consistently observed better outcomes in immunologically “hot” HCC. We summarised possible mechanisms of tumour immune evasion based on the latest literature and the rationale for combination/sequential therapy to improve treatment response. Lastly, we proposed future strategies and therapies to overcome HCC immune evasion to further improve treatment outcomes of HCC.
Ventricular Netrin-1 deficiency leads to defective pyramidal decussation and mirror movement in mice
Authors: Hu Ling , Liu Xi-Yue , Zhao Li , Hu Zhi-Bin , Li Ze-Xuan , Liu Wei-Tang , Song Ning-Ning , Hu Yun-Qing , Jiang Luo-Peng , Zhang Lei , Tao Yun-Chao , Zhang Qiong , Chen Jia-Yin , Lang Bing , Wang Yu-Bing , Yue Lei , Ding Yu-Qiang 
Published: May 2024

AbstractThe corticospinal tract (CST) is the principal neural pathway responsible for conducting voluntary movement in the vertebrate nervous system. Netrin-1 is a well-known guidance molecule for midline crossing of commissural axons during embryonic development. Families with inherited Netrin-1 mutations display congenital mirror movements (CMM), which are associated with malformations of pyramidal decussation in most cases. Here, we investigated the role of Netrin-1 in CST formation by generating conditional knockout (CKO) mice using a Gfap-driven Cre line. A large proportion of CST axons spread laterally in the ventral medulla oblongata, failed to decussate and descended in the ipsilateral spinal white matter of Ntn1Gfap CKO mice. Netrin-1 mRNA was expressed in the ventral ventricular zone (VZ) and midline, while Netrin-1 protein was transported by radial glial cells to the ventral medulla, through which CST axons pass. The level of transported Netrin-1 protein was significantly reduced in Ntn1Gfap CKO mice. In addition, Ntn1Gfap CKO mice displayed increased symmetric movements. Our findings indicate that VZ-derived Netrin-1 deletion leads to an abnormal trajectory of the CST in the spinal cord due to the failure of CST midline crossing and provides novel evidence supporting the idea that the Netrin-1 signalling pathway is involved in the pathogenesis of CMM.
Sustained-release drug delivery systems
Authors: Williams Rachel , Cauldbeck Helen , Kearns Victoria 
Published: May 2024

AbstractThe design and development of a sustained-release drug delivery system targeting the administration of active pharmaceutical ingredients (APIs) to the eye could overcome the limitations of topically administered eye drops. Understanding how to modify or design new materials with specific functional properties that promote the attachment and release of specific drugs over longer time periods, alongside understanding clinical needs, can lead to new strategic opportunities to improve treatment options. In this paper we discuss two approaches to the design or modification of materials to produce a sustained therapeutic effect. Firstly, we discuss how the synthesis of a peptide hydrogel from a naturally-derived antimicrobial material led to the design of a bandage contact lens which may be able to be used prophylactically to reduce post-surgery infection. Secondly, we discuss how silicone oil tamponade agents used to treat retinal detachments can have adjunctive behaviour to enhance the solubility of the anti-proliferative drug retinoic acid and produce a sustained release over several weeks. These studies are the result of close partnerships between clinical ophthalmologists, materials scientists, and chemists, and illustrate how these partnerships can lead to comprehensive understandings that have the potential to change patient outcomes.
Temporal trends in clinical features of patients with primary aldosteronism over 20 years
Authors: Park Seung Shin , Ahn Chang Ho , Kim Sang Wan , Koh Jung-Min , Lee Seung Hun , Kim Jung Hee 
Published: May 2024

AbstractPrimary aldosteronism (PA) accounts for approximately 5-10% of hypertension cases. Over the past 20 years, the reported incidence of PA has increased due to widespread screening for secondary hypertension and imaging studies. We aimed to evaluate the temporal trends in the clinical characteristics and subtypes of PA. A total of 1064 patients with PA in two tertiary hospitals between 2000 and 2021 were categorized into three groups according to the year of diagnosis: 2000–2009, 2010–2015, and 2016–2021. The clinical characteristics of the patients over the three time periods were compared using a trend analysis. The age at diagnosis and sex of patients with PA did not change over 20 years. The proportion of patients with bilateral hyperaldosteronism (BHA) increased (11%, 25%, and 40%, P for trend <0.001). The proportion of hypokalemia (87%, 61%, and 40%) and plasma aldosterone concentration (36.0, 30.8, and 26.6 ng/dL) decreased (all P for trend <0.001). There was a trend toward an increased proportion of incidentally detected patients compared to clinically symptomatic patients (36%, 55%, and 61%, P for trend <0.001). The concordance rate of imaging and adrenal venous sampling results decreased (91%, 70%, and 57% P for trend <0.001). However, the proportion of patients with resistant hypertension and comorbidities did not differ. In conclusion, among patients with PA, patients with BHA and incidental detection have increased over 20 years, and more patients are likely to present with milder clinical symptoms and biochemical profiles.
Pudendal nerve block decreases narcotic requirements and time spent in post-anesthesia care units in patients undergoing primary inflatable penile prosthesis implantation
Authors: Zhu Michael , Labagnara Kevin , Loloi Justin , Babar Mustufa , Harandi Arshia Aalami , Salami Azizou , Bernstein Ari , Davila Jonathan , Davuluri Meenakshi , Chalouhy Charbel , Maria Pedro 
Published: May 2024

AbstractEfforts to minimize narcotic usage following inflatable penile prosthesis (IPP) implantation are vital, considering the current opioid epidemic in the United States. We aimed to determine whether pudendal nerve block (PNB) utilization in a multiethnic population undergoing primary IPP implantation can decrease rates of post-operative opiate usage. A single-institution, retrospective study was conducted on patients who underwent primary IPP implantation between December 2015 and June 2022. PNB usage and intra- and post-operative outcomes were analyzed using multivariate binary logistic regression. 449 patients were included, with 373 (83.1%) in the PNB group. Median time (minutes) spent in the post-anesthesia care unit (PACU) (1499 [119–198] vs. 235 [169–322], p < 0.001) was significantly lower in the PNB group. There were no significant differences in intra-operative and PACU morphine milligram equivalents or post-operative safety outcomes between groups. However, fewer patients in the PNB group called for pain medications post-operatively (10.2% vs 19.7%, p = 0.019). Multivariate analysis revealed a significantly decreased operative time (B −6.23; 95%CI −11.28, −1.17; p = 0.016) and decreased time in recovery (B: −81.62; 95%CI: −106.49, −56.76, p < 0.001) in the PNB group. PNB decreases post-operative opioid analgesic requirements and time spent in PACU in patients undergoing a primary IPP implantation and thus may represent an attractive, non-opioid adjunct.