bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of multi-criteria decision analysis in evaluating the value of drug-oriented intervention: a literature review
Authors: Su Pengli , Zhi Kai , Xu Huanhuan , Xiao Jing , Liu Jun , Wang Zhong , Liu Qiong , Yu Yanan , Dang Haixia 
Published: April 2024

Objectives: Multi-Criteria Decision Analysis (MCDA) has gained increasing attention in supporting drug risk-benefit assessment, pricing and reimbursement, as well as optimization of clinical interventions. The objective of this study was to systematically collect and categorize evaluation criteria and techniques of weighting and scoring of MCDA for drug value assessment.Methods: A systematic review of the literature was conducted across seven databases to identify articles utilizing the MCDA frameworks for the evaluation of drug value. Evaluation criteria mentioned in the included studies were extracted and assigned to 5 dimensions including clinical, economic, innovative, societal and humanistic value. A descriptive statistical analysis was performed on the identified drug value evaluation criteria, as well as the weighting and scoring techniques employed. The more a criterion or technique were mentioned in articles, the more important we consider it.Results: Out of the 82 articles included, 111 unique criteria were identified to evaluate the value of drug. Among the 56 unique criteria (448 times) used to measure clinical value, the most frequently mentioned were “comparative safety/tolerability” (58 times), “comparative effectiveness/efficacy” (56 times), “comparative patient-perceived health/patient reported outcomes” (37 times), “disease severity” (34 times), and “unmet needs” (25 times). Regarding economic value measurement, out of the 20 unique criteria (124 times), the most frequently utilized criteria were “cost of intervention” (17 times), “comparative other medical costs” (16 times), and “comparative non-medical costs” (18 times). Out of the 10 criteria (18 times) for assessing innovative value, “a novel pharmacological mechanism” was the most frequently mentioned criterion (5 times). Among the 22 criteria (73 times) used to measure societal value, “system capacity and appropriate use of intervention” was the most frequently cited criterion (14 times). Out of the 3 criteria (15 times) utilized to measure humanistic value, “political/historical/cultural context” was the most frequently mentioned criterion (9 times). Furthermore, 11 scoring and 11 weighting techniques were found from various MCDA frameworks. “Swing weighting” and “a direct rating scale” were the most frequently used techniques in included articles.Conclusion: This study comprehensively presented the current evaluation dimensions, criteria, and techniques for scoring and weighting in drug-oriented MCDA articles. By highlighting the frequently cited evaluation criteria and techniques for scoring and weighting, this analysis will provide a foundation to reasonably select appropriate evaluation criteria and technique in constructing the MCDA framework that aligns with research objectives.
Modeling lexical abilities of heritage language and L2 speakers of Hebrew and English in Israel and the United States: a network approach
Authors: Fridman Clara , Livni Adina , Bar On Sagit , Meir Natalia 
Published: April 2024

IntroductionThis paper examines the productive vocabulary skills of five groups of English-Hebrew bilinguals in Israel and the United States. The juxtaposition of these five groups allows us to simultaneously compare performance across dominance profiles, acquisition contexts (L2 learned in school, HL maintained at home, immigration and immersion), and countries (Israel and the USA).MethodsA total of 185 participants took part in study: Hebrew-dominant heritage English speakers, Hebrew-dominant L2-English speakers, English-dominant heritage Hebrew speakers, and English-dominant L2-Hebrew speakers in the US and in Israel. They were all administered the MINT assessment in both languages, as well as background questionnaires. We then employ network modeling based on a secondary data analysis of background questionnaires to consider how each group’s lexical proficiency ties in to reported input factors.Results and discussionThe MINT results indicate clear language dominance in all the groups except Hebrew-dominant heritage English speakers, who show balanced proficiency in both their languages. The network models indicate key distinctions between the groups as a function of linguistic context, and we assess our findings in the context of recent work on quantifying the bilingual experience.
The mediating role of resilience and interaction anxiousness in the effects of physical activity on mobile phone addiction among Chinese college students
Authors: Wu Jinlong , Xiao Wen , Liu Bowen , Yu Jingxuan , Zheng Kangyong , Shi Qiuqiong , Ren Zhanbing 
Published: April 2024

BackgroundRecent studies have shown that regular physical activity (PA) can positively influence mobile phone addiction (MPA) behaviors in college students. However, it remains unknown whether this effect is mediated by other factors. Evidence suggests that resilience and interaction anxiousness may be candidate mediators that partly explain the positive effect of PA on MPA. This study aims to explore the impact of PA on MPA through a mediation model, and the role of resilience and interaction anxiousness in this relationship.MethodsThe participants were 590 college students (272 males; mean age = 19.67) who completed a psychosocial battery, including the international physical activity questionnaire—short form (IPAQ-SF), the connor - davidson resilience scale (CD-RISC), the interaction anxiousness scale (IAS), and the mobile phone addiction index (MPAI). Correlations of variables were computed using Pearson’s test. Mediation models were tested using SPSSS PROCESS macro with the regression bootstrapping method.ResultsPA were negatively associated with MPA behavior (r=-.21, p &lt; 0.01). Resilience and interaction anxiousness moderated the relationship between PA and MPA. More importantly, PA could also influence MPA through the chain-mediating effects of resilience and interaction anxiousness.ConclusionIt is essential to improve resilience and reduce interaction anxiousness to reduce MPA problems through regular engagement in PA among college students.
Promising directions for human-robot interactions defined by older adults
Authors: Ostrowski Anastasia K. , Zhang Jenny , Breazeal Cynthia , Park Hae Won 
Published: April 2024

Introduction: Older adults are engaging more and more with voice-based agent and social robot technologies, and roboticists are increasingly designing interactions for these systems with older adults in mind. Older adults are often not included in these design processes, yet there are many opportunities for older adults to collaborate with design teams to design future robot interactions and help guide directions for robot development.Methods: Through a year-long co-design project, we collaborated with 28 older adults to understand the key focus areas that older adults see promise in for older adult-robot interaction in their everyday lives and how they would like these interactions to be designed. This paper describes and explores the robot-interaction guidelines and future directions identified by older adults, specifically investigating the change and trajectory of these guidelines through the course of the co-design process from the initial interview to the design guideline generation session to the final interview. Results were analyzed through an adapted ethnographic decision tree modeling approach to understand older adults’ decision making surrounding the various focus areas and guidelines for social robots.Results: Overall, over the course of the co-design process between the beginning and end, older adults developed a better understanding of the robot that translated to them being more certain of their attitudes of how they would like a robot to engage with them in their lives. Older adults were more accepting of transactional functions such as reminders and scheduling and less open to functions that would involve sharing sensitive information and tracking and/or monitoring of them, expressing concerns around surveillance. There was some promise in robot interactions for connecting with others, body signal monitoring, and emotional wellness, though older adults brought up concerns around autonomy, privacy, and naturalness of the interaction with a robot that need to be further explored.Discussion: This work provides guidance for future interaction development for robots that are being designed to interact with older adults and highlights areas that need to be further investigated with older adults to understand how best to design for user concerns.
Determining the Public Health Impact of Climate Change: A National Study Using a Health Impact Assessment Approach in Wales
Authors: Green Liz , Ashton Kathryn , Edmonds Nerys , Fletcher Michael , Azam Sumina , Hughes Karen , Wheater Phil , Bellis Mark A. 
Published: April 2024

Objective: Climate change is recognised as the biggest threat to global health of the 21st century and impacts on health and wellbeing through a range of factors. Due to this, the need to take action in order to protect population health and wellbeing is becoming ever more urgent.Methods: In 2019, Public Health Wales carried out a comprehensive mixed-method Health Impact Assessment (HIA) of climate change. Unlike other risk assessments, it appraised the potential impact of climate change on health and inequalities in Wales through participatory workshops, stakeholder consultations, systematic literature reviews and case studies.Results: The HIA findings indicate potential impacts across the wider determinants of health and wellbeing. For example, air quality, excess heat/cold, flooding, economic productivity, infrastructure, and community resilience. A range of impacts were identified across population groups, settings, and geographical areas.Conclusion: These findings can inform decision-makers to prepare for climate change plans and policies using an evidence-informed approach. The work has demonstrated the value of a HIA approach by mobilising a range of evidence through a transparent process, resulting in transferrable learning for others.
The eTEP/eTEP-TAR Repair of Ventral Hernias a Study From One Center/ One Surgeon—The First Five Years of Experience
Authors: Radu Victor G. , Cucu Diana Teodora 
Published: April 2024

Objective: The objective of this study is analyze the outcomes of retro-muscular repair techniques for ventral hernias performed by a single surgeon in a renowned hernia surgery center.Method: This study involved 197 patients who underwent surgery between May 2016 and December 2021 under the care of a single surgeon (VR). Respecting the indication/contraindications of the eTEP procedure, 197 of 212 patients with ventral hernias underwent eTEP/eTEP-TAR surgery during this period. The cohort consisted of diverse hernia types, including median, lateral, and multiple-site defects. The safety of this approach was evaluated based on postoperative occurrences, where the number of complications accounted for 5% of the cases.Results of the study indicated that there was a significant improvement in the quality of life of patients following the procedure. The assessment, which measured postoperative pain, normal activity, and aesthetics on a 0–10 scale, showed improvement at 2 weeks and 3 months after surgery compared to the preoperative level. However, after a mean of 51.11 months, only one case of recurrence was reported. This recurrence occurred on top of the mesh, 18 months after the initial operation. The follow-up period lasted between 24 and 90 months. Patient monitoring was conducted either in person or over the phone, focusing on quality of life, postoperative pain, and the occurrence of recurrence. In conclusion, the laparo-endoscopic retro-muscular repair of ventral hernias, whether primary or incisional, has shown to yield excellent results in medium and long-term follow-up. The eTEP technique combines the benefits of the Rives-Stoppa technique (considered the gold standard in open ventral hernia repair) with the advantages of minimally invasive surgery.
Local C0,1-Regularity for the Parabolic p-Laplacian Equation on the Group SU(3)
Authors: He Yongming , Yu Chengwei , Wang Hongqing 
Published: April 2024

In this article, when 2≤p≤4, we establish the Cloc0,1-regularity of weak solutions to the degenerate parabolic p-Laplacian equation ∂tu=−∑i=16Xi*(|∇Hu|p−2Xiu) on the group SU(3) granted with horizontal vector fields X1, …, X6. Compared to the Heisenberg group, Hn, we obtained the optimal range of p; that is, 2≤p≤4.
Design and validation of a piezoelectric diaphragm micropump for drug delivery
Authors: Zamora Mauricio Calderon , Betanzo Claudia Reyes 
Published: April 2024

There is a common eye ailment called Dry Eye Disease (DED) that causes symptoms of discomfort, visual disturbance, and tear film instability, which cause damage to the ocular surface. For treatment of this illness, the application of artificial tear fluid is usually prescribed. This work presents the design process of a piezoelectric micropump to become part of an automatic pumping system for delivering artificial tear fluid to people suffering from DED. Low polarizing voltage, portability, and achieving a variable output flow rate in the range of 1 µl/min, which is the necessary range needed by a person suffering from DED, are the focus of this design. Standard microfabrication techniques widely used in the CMOS industry and for MEMS development will be used for manufacturing the proposed micropump. For this reason, the materials and manufacturing processes involved must be CMOS-compliant. For the piezoelectric actuator, zinc oxide (ZnO) was selected due to its compatibility with CMOS technology and because it is readily available in thin film form through a sputtering process. Other materials involved in the device are silicon and aluminum. The design was validated through finite element analysis software, COMSOL Multiphysics®. The maximum flow rate obtained by a single micropump device was 2.51µl/min operating at 20V peak with a frequency of 900Hz. Also, the flow rate is controllable through variations in frequency, thus making it suitable for the application previously described.
Da etiologia ao tratamento: uma revisão bibliográfica da puberdade precoce
Authors: Mancini Olga Parente , Siqueira Gisele Canela de , Silva Luciana Canela de Siqueira 
Published: April 2024

A puberdade precoce é marcada pelo desenvolvimento de caracteres sexuais secundários antes dos 8 anos em meninas e antes dos 9 anos em meninos, sendo mais prevalente em meninas. A puberdade precoce GnRH-dependente patológica (puberdade precoce central) cursa com progressão dos caracteres puberais, aumento significativo da velocidade de crescimento e avanço desproporcional da idade óssea, resultando na redução da estatura final prevista na vida adulta. O objetivo do trabalho foi analisar os principais fatores causadores, métodos de diagnóstico e o manejo da puberdade precoce, visando melhorar a compreensão clínica da patologia. Trata-se de uma pesquisa do tipo revisão bibliográfica, feita nas plataformas de busca avançada MEDLINE- PubMed (National Library of Medicine, National Institutes of Health) com os descritores selecionados por meio da plataforma DeCS: “Puberty, Precocious”, “Drug Therapy”, “Gonadotropin Releasing Hormone”, combinados pelo operador booleano AND. Como critérios de inclusão, foram considerados artigos em inglês, português ou espanhol, publicados de 2018 a 2023, com foco em ensaios clínicos randomizados e duplos cegos. Com a metodologia de busca aplicada, foram encontrados 22 artigos. Após realizar a exclusão de duplicatas e a análise criteriosa, 11 trabalhos foram selecionados, dos quais 6 abordaram sobre a epidemiologia e diagnóstico, enquanto os outros 5 discutiram as opções de tratamentos disponíveis para a puberdade precoce. A revisão da literatura revela que a puberdade precoce é um fenômeno multifatorial, com causas que podem variar desde anormalidades no eixo hipotálamo-hipofisário até influências genéticas e ambientais. A identificação precoce e precisa da etiologia subjacente é de suma importância para a elaboração de estratégias terapêuticas eficazes. Em casos de puberdade precoce central, a terapia com análogos do hormônio liberador de gonadotropina (GnRH) pode ser utilizada como uma abordagem eficaz para suprimir a atividade do eixo hipotálamo-hipofisário e retardar o desenvolvimento puberal, proporcionando tempo adicional para o crescimento linear e minimizando as consequências da puberdade precoce. No entanto, este tratamento possui muitos desafios, incluindo a necessidade de administração prolongada, efeitos colaterais potenciais e o impacto na qualidade de vida. Portanto, abordagens terapêuticas personalizadas, que levem em consideração as causas subjacentes e as necessidades individuais dos pacientes, representam uma área de pesquisa em evolução. Dessa forma, destaca-se a necessidade de pesquisas adicionais visando aperfeiçoar a compreensão clínica desta condição e desenvolver terapêuticas mais precisas.
Reflexões sobre o crescente número de cesáreas no Brasil: um chamado à consciência
Authors: Lourenço Amanda Mendes , Montandon Beatriz Soares , Abreu Camila Pereira , Gouvêa Clara Michele Madureira Yamim , Sotto-Maior Larissa Rodrigues , Braga Lucas Moreira , Azevedo Maria Claudia Ferreira Bezerra de , Diniz Rebecca Maria Campos , Marques Thâmera Petra Alfenas , Frade Victor Lauer 
Published: April 2024

INTRODUÇÃO: A incidência de cesarianas tem aumentado ao longo das décadas em escala global, e no Brasil, esse índice atingiu uma marca significativa de 56% - colocando-o substancialmente acima da média observada em nações em desenvolvimento. METODOLOGIA: Revisão narrativa da literatura realizada a partir da busca bibliográfica na base de dados PubMed, com os descritores “Cesarean”, “Prenatal care”, “Childbirth”. RESULTADOS: Os estudos pesquisados foram publicados em periódicos internacionais, sendo selecionados artigos de revisão, revisão sistemática e metanálise. DISCUSSÃO: No contexto obstétrico nacional, a tendência de aumento nas taxas de cesáreas começou a se manifestar em 2017 e foi exacerbada pela pandemia. Apesar dos esforços para reorganizar a rede de assistência pré-natal durante o período pandêmico, especialmente para pacientes com risco obstétrico, na prática, esses esforços foram limitados. Consequentemente, observou-se um influxo de gestantes em estágios avançados de complicações obstétricas nas unidades de maternidade, muitas das quais necessitando de cesariana para mitigar desfechos materno-perinatais desfavoráveis. CONCLUSÃO: Em conclusão, o aumento nas taxas de cesáreas no Brasil, que já vinha sendo observado há quase uma década e foi intensificado durante a pandemia, destaca a necessidade urgente de políticas e práticas que promovam uma abordagem mais equilibrada e baseada em evidências na assistência obstétrica.
Além dos números: uma análise da disparidade nos casos de suicídio entre os sexos no estado de Alagoas, no período de 2017 a 2021
Authors: Alves Darah Yasmim Moreira , Ribeiro Maria Victoria de Morais Born , Andrade Pedro Nogueira de , Euzébio Rayara Fernanda Duarte , Oliveira Victor Meneses , Souza Matheus José Nery de , Carvalho Viviane Targino , Vasconcelos Laynny da Trindade , Barbosa Arianna Gonçalves , Guedes Maria Victoria Nesso , Cotrim Gabriela Barbosa , Cavalcante Maria Eduarda de Araújo 
Published: April 2024

Introdução: Segundo a OMS, as mortes por suicídio aumentaram 60% em 50 anos. A taxa global é de cerca de 16 por 100 mil habitantes. Em 2000, aproximadamente 1 milhão de pessoas se suicidaram, uma a cada 40 segundos. As projeções indicam mais de 1,5 milhão de suicídios em 2020. Objetivo: analisar a disparidade da mortalidade por suicídio entre os sexos feminino e masculino no Estado de Alagoas, no período de 2017 a 2021. Metodologia: Trata-se de um estudo observacional transversal, descritivo, através do levantamento de dados epidemiológicos. As informações epidemiológicas e de morbidade, bem como as de estatísticas vitais e de mortalidade foram obtidas no Departamento de Informática do Sistema Único de Saúde (DATASUS). Resultados: Destaca-se a notável prevalência no gênero masculino, representando 75% das notificações, o enforcamento representa a principal causa, contribuindo com alarmantes 75,28% das mortes por suicídio. No que diz respeito ao estado civil, a maioria era composta por solteiros, totalizando 60,53%. Conclusão: Identificadas na pesquisa, as limitações incluem a falta de um sistema de vigilância adequado para o comportamento suicida e a subnotificação, especialmente no Estado de Alagoas. Familiares muitas vezes ocultam os casos por vergonha e estigma, resultando em taxas baixas relatadas ao sistema de saúde pública.
Educação ambiental na Escola Municipal Odete Maria de Almeida, Caravelas - BA
Authors: Araújo Willians Chaves de , Oliveira Gisele Lopes de 
Published: April 2024

A Educação Ambiental tem como um de seus objetivos a promoção de ações individuais e coletivas de conservação de recursos naturais, através de uma visão prática, estimulando o olhar crítico, a valorização do meio ambiente, propondo proximidade ao cotidiano do estudante ao longo de processo educativo. A escola é um lugar favorável à educação ambiental pois associa interdisciplinarmente à indispensável relação do ser humano com o ambiente. Sendo assim, o presente trabalho objetivou promover a sensibilização quanto à proteção ambiental, por meio de encontros e oficinas, com estudantes e professores da Escola Municipal Odete Maria de Almeida, Caravelas, BA. Para isso, foram realizadas discussões com os estudantes e quatro oficinas de caráter pedagógico, direcionadas para os Eixos Temáticos: Meio Ambiente, Resíduos, Solos e Água. O tema Meio Ambiente foi trabalhado com foco nas plantas medicinais, no de Resíduos trabalhou-se com a confecção de composteira, na temática Solos foi construído uma horta para cultivo de hortaliças e plantas medicinais e discutiu-se a última temática sobre Água, alertando sobre doenças e qualidade da água. Em todas as oficinas a participação de estudantes e professores foi efetiva, colaborativa e entusiasmada.
KONTRIBUSI PENDAPATAN BURUH USAHA PABRIK TAHU MAS GENDON TERHADAP PENDAPATAN KELUARGA DI KELURAHAN KAROMBASAN UTARA KECAMATAN WANEA KOTA MANADO
Authors: Palit Merry Claudia , Tangkere Ellen , Mandei Juliana R. 
Published: April 2024

This study aims to determine the contribution of the income of Mas Gendon's tofu factory workers to family income. This research was conducted in North Karombasan Village, North District, Manado City. The data used in this research are primary data and secondary data. Primary data were obtained from direct interviews with owners and workers of the tofu factory Mas Gendon by distributing questionnaires, secondary data obtained through monograph data and the internet. The Â number of respondents is 5 people. The method of taking respondents using the census method is to make the entire population. The variables measured were the characteristics of the respondents, the income of the workers' family members, the reasons for working, and the time spent by the workers. The data analysis method used is family income and contribution. Based on the results of the research, the contribution of the income of Mas Gendon's tofu factory workers to family income in the North Karombasan Village, Wanea District, Manado City, workers get a wage of 2,000,000/month, and get housing and eating facilities. The time spent by workers in domestic activities is 1.8 hours, productive activities are 16 hours, and other activities are 6.2 hours. Income from workers has a contribution of (76.92%) which is categorized as very large because the value is >50% of the contribution criteria, income from other family members is (23.08%) which is categorized as being in the contribution category.