bluuebunny/crossref_metadata_2025_split huggingface dataset:
The pathologic characteristics of breast cancer in China and its shift during 1999–2008: A national‐wide multicenter cross‐sectional image over 10 years
Authors: Zheng Shan , Bai Jing‐Qiao , Li Jing , Fan Jin‐Hu , Pang Yi , Song Qing‐Kun , Huang Rong , Yang Hong‐Jian , Xu Feng , Lu Ning , Qiao You‐Lin 
Published: February 2012

AbstractIn China, breast cancer is currently the most common malignancy and the sixth leading cause of cancer death in women. But, the characteristics of breast cancer in the whole population are not determined. The aim of this study was to perform a detailed study on pathologic characteristics of breast cancer representing the whole population in China during 1999–2008 and to compare the difference in invasive breast cancer between the Western and Chinese. We randomly collected 4,211 inpatient at seven hospitals in representative geographical regions of China during 1999–2008. All the hospitals had the ability of comprehensive cancer treatment. The pathologic characters including estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status were surveyed. The shift of pathologic characters was evaluated and the data from China were also compared with those of the Western, both using Chi‐square test. We found as follow. (i) The median age of the patients was 48 years and showed the similar characters of Asia. (ii) Breast cancer in China showed more invasive ductal carcinoma with larger tumor size, later stage, lower ER and PR expression and higher HER2 overexpression than those in the Western (p < 0.001). (iii) Both tumor size and stage at diagnosis decreased year by year (p < 0.001). Breast cancer in China showed more aggressive behavior than those in western countries, although tumor size and stage at diagnosis decreased by year during 1999–2008. We addressed the urgent needs for employ race‐specific breast cancer screen, diagnosis methods, and therapeutic models in China.
Artesunate induces apoptosis via a Bak‐mediated caspase‐independent intrinsic pathway in human lung adenocarcinoma cells
Authors: Zhou Chenjuan , Pan Wenliang , Wang Xiao Ping , Chen Tong Sheng 
Published: February 2012

AbstractThis report is designed to explore the exact molecular mechanism by which artesunate (ART), a semisynthetic derivative of the herbal antimalaria drug artemisinin, induces apoptosis in human lung adenocarcinoma (ASTC‐a‐1 and A549) cell lines. ART treatment induced ROS‐mediated apoptosis in a concentration‐ and time‐dependent fashion accompanying the loss of mitochondrial potential and subsequent release of Smac and AIF indicative of intrinsic apoptosis pathway. Blockage of casapse‐8 and ‐9 did not show any inhibitory effect on the ART‐induced apoptosis, but which was remarkably prevented by silencing AIF. Of the utmost importance, ART treatment induced the activation of Bak but not Bax, and silencing Bak but not Bax remarkably inhibited ART‐induced apoptosis and AIF release. Furthermore, although ART treatment did not induced a significant down‐regulation of voltage‐dependent anion channel 2 (VDAC2) expression and up‐regulation of Bim expression, silencing VDAC2 potently enhanced the ART‐induced Bak activation and apoptosis which were significantly prevented by silencing Bim. Collectively, our data firstly demonstrate that ART induces Bak‐mediated caspase‐independent intrinsic apoptosis in which Bim and VDAC2 as well as AIF play important roles in both ASTC‐a‐1 and A549 cell lines, indicating a potential therapeutic effect of ART for lung cancer. J. Cell. Physiol. 227: 3778–3786, 2012. © 2012 Wiley Periodicals, Inc.
Laser ablation in titanium implants followed by biomimetic hydroxyapatite coating: Histomorphometric study in rabbits
Authors: Faeda Rafael Silveira , Spin‐Neto Rubens , Marcantonio Elcio , Guastaldi Antonio Carlos , Marcantonio Elcio 
Published: March 2012

AbstractTitanium surface texture and chemistry modification successfully improves the host response and consequently the bone‐to‐implant contact surrounding dental implants. The aim of the present study was to investigate, using histomorphometrical‐analysis, the effects of titanium surface modification by laser‐ablation (Nd:YAG) followed by thin chemical deposition of HA. Forty‐eight rabbits received one implant by tibiae of AS‐machined (MS), laser‐modified (LMS), or biomimetic hydroxyapatite‐coated (HA) surface. Bone‐to‐implant contact (BIC) and bone area (BBT) were evaluated after 4, 8, and 12 weeks, at cortical and cancellous regions. Average BIC in the cortical region was higher (P< 0.001) on the LMS and HA implants for all periods, with no differences between LMS and HA. For the cancellous area, the LMS and HA implants showed higher (P< 0.01) BIC than MS at the initial periods. The LMS and HA showed similar values in the cortical region, but a tendency of higher values for HA in the cancellous region was observed in all periods. For the BBT, the differences were found only between HA and MS after 4 weeks in the cortical region (P< 0.05), and after 12 weeks in the cancellous area (P< 0.05). Our results showed that HA biomimetic coating preceded by laser treatment induced the contact osteogenesis and allowed the formation of a more stable bone–implant interface, even in earlier periods. Microsc. Res. Tech., 2012. © 2012 Wiley Periodicals, Inc.
Exploring the behaviour of atmospheric temperatures under dry conditions in Europe: evolution since the mid‐20th century and projections for the end of the 21st century
Authors: Beniston Martin 
Published: February 2012

AbstractIn a changing climate, it is likely that precipitation patterns will experience shifts in amount and seasonality, with a tendency towards increased drought in many parts of Europe. In order to investigate what could be some of the feedbacks of dry conditions on temperature, this paper has investigated close to 30 European locations to assess the influence of observed dry summer days on daily maximum temperature (Tmax) as well as a clustering of rainless days, and finally the temperature impact related to drought conditions as defined by the Standardized Precipitation Index. The results show that for the three main European climatic regions investigated (‘Mediterranean’, ‘Maritime’, ‘Continental’), the influence of rainless days is discernible, with an average difference between mean summer Tmax and Tmax during rainless days only of up to 1.5 °C. A further aim of the study is to determine whether recent shifts in the occurrence of rainless days during the summer have a bearing on temperature trends. Results show that shifts in rainless days explain only a fraction of the observed temperature change at the locations studied, thereby hinting that the enhanced greenhouse effect remains the dominant mechanism for temperature change. Finally, using a regional climate model, very preliminary insight into a ‘greenhouse climate’ highlights the fact that changes in dry conditions seem to confirm the findings for current climate, i.e. they account for only a fraction of the increase in temperatures. Copyright © 2012 Royal Meteorological Society
Differential analysis of peripheral blood‐ and bone marrow‐derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering
Authors: Amini Ami R. , Laurencin Cato T. , Nukavarapu Syam P. 
Published: February 2012

AbstractFor tissue engineering applications, effective bone regeneration requires rapid neo‐vascularization of implanted grafts to ensure the survival of cells in the early post‐implantation phase. Incorporation of autologous endothelial progenitor cells (EPCs) for the promotion of primitive vascular network formation ex vivo has offered great promise for improved graft survival, enhanced rate of vascularization and bone regeneration in vivo. For clinical usage, identification of an optimal EPC isolation source from the patient is critical. We have, for the first time, characterized and directly compared EPCs from rabbit peripheral blood and bone marrow (PB‐EPCs and BM‐EPCs, respectively). PB‐EPCs outperformed BM‐EPCs on all measures. PB‐EPCs displayed typical endothelial cell markers, such as CD31, as well as high angiogenic potential in three‐dimensional extracellular matrix in vitro. Furthermore, PB‐EPCs cultured simultaneously with mesenchymal stem cells, displayed significantly enhanced expression levels of key osteogenic and vascular markers, including alkaline phosphatase, bone morphogenetic protein 2, and vascular endothelial growth factor. On the contrary, putative BM‐EPCs did not express CD31, and instead, expressed key smooth muscle markers. BM‐EPCs further failed to display vasculogenic activity. Hence, the highly angiogenic PB‐derived EPCs may serve as an ideal cell population for enhanced vascularization and success of engineered bone tissue. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:1507–1515, 2012
Cervical lymph node metastasis and papillary thyroid carcinoma: Does the compartment involved affect survival? Experience from the SEER database
Authors: Smith Valerie A. , Sessions Roy B. , Lentsch Eric J. 
Published: March 2012

AbstractPurposeDetermine how the location of cervical lymph node metastases affects survival in papillary thyroid carcinoma (PTC) patients.MethodsThe Surveillance, Epidemiology, and End Results (SEER) database was queried for patients diagnosed with PTC. Disease specific survival (DSS) was estimated according to node status and extent of cervical involvement by Kaplan–Meier analysis. Hazard ratios with 95% confidence intervals to estimate the risk of death were calculated using Cox multivariable regression analysis.ResultsWe identified 11,453 PTC cases in the SEER database with complete data describing the absence or location of positive nodes. Of these, 40.1% were node‐positive; 56.6%, 34.1%, and 9.3% of node‐positive patients had metastasis to the central, lateral, and mediastinal compartments, respectively. DSS was worse for node‐positive patients age ≥45 with lateral/mediastinal involvement relative to those with central metastasis (P < 0.001). Node metastasis did not significantly affect survival for patients age <45, regardless of location.ConclusionsPatients age ≥45 with lateral/mediastinal cervical involvement have an increased risk of death from PTC in the initial years after diagnosis. Future studies are needed to elucidate optimal treatment and surveillance protocols for these patients, and also to ascertain the effect of cervical node location on long‐term survival and disease‐recurrence. J. Surg. Oncol. 2012; 106:357–362. © 2012 Wiley Periodicals, Inc.
Stereocomplexes from Biosourced Lactide/Butylene Succinate‐Based Copolymers and Their Role as Crystallization Accelerating Agent
Authors: Mincheva Rosica , Raquez Jean‐Marie , Lison Valérie , Duquesne Emmanuel , Talon Olivier , Dubois Philippe 
Published: February 2012

AbstractBiosourced co(polyester urethane)s containing different ratios of enantiomeric oligo(L‐ or D‐ lactide) (OLLA/ODLA) sequences and oligo(butylene succinate) (OBS) blocks (P(OD(L)LA‐b‐OBS)) are synthesized. Their stereocomplexation is confirmed by differential scanning calorimetry and X‐ray diffraction. The process is efficient independently on the OLA/OBS ratio and for OLLA/ODLA ratios from 2:3 to 3:2. The preformed stereocomplexes show remarkable crystallization accelerating efficiency when melt‐blended with a commercial PLLA in amounts from 2.5 to 10 wt%. Spectacular increase in the polyester matrix crystallinity (from 2 up to 42%) and crystallization rate (half‐time of ca. 3 min compared to ca. 30 min for the neat PLLA) is observed.
Matrix Order Influence on the Non‐Linear Optical Properties of Dispersed Chromophore‐Azopolymer Systems
Authors: Alicante Raquel , Cases Rafael , Villacampa Belén , Blasco Eva 
Published: March 2012

AbstractAzopolymers with moderate non‐linear optical (NLO) response are used as host matrices for a highly efficient molecule. The second harmonic intensity generated at room temperature by these binary systems increases noticeably by adding an irradiation step (406 nm) to the corona poling process. The free volume increase due to “trans‐cis” photoisomerization of the side‐chain azo moieties allows to align the NLO chromophores and causes, at least partially, this enhancement. In order to investigate the role of guest–host interactions on the NLO response, different matrix arrangements have been induced and different d33/d.
New Trends in the Optical and Electronic Applications of Polymers Containing Transition‐Metal Complexes
Authors: Liu Shu‐Juan , Chen Yang , Xu Wen‐Juan , Zhao Qiang , Huang Wei 
Published: March 2012

AbstractPolymers containing transition‐metal complexes exhibit excellent optical and electronic properties, which are different from those of polymers with a pure organic skeleton and combine the advantages of both polymers and metal complexes. Hence, research about this class of polymers has attracted more and more interest in recent years. Up to now, a number of novel polymers containing transition‐metal complexes have been exploited, and significant advances in their optical and electronic applications have been achieved. In this article, we summarize some new research trends in the applications of this important class of optoelectronic polymers, such as chemo/biosensors, electronic memory devices and photovoltaic devices.
IR TrueFISP with a golden‐ratio‐based radial readout: Fast quantification of T1, T2, and proton density
Authors: Ehses Philipp , Seiberlich Nicole , Ma Dan , Breuer Felix A. , Jakob Peter M. , Griswold Mark A. , Gulani Vikas 
Published: February 2012

AbstractA promising approach for the simultaneous quantification of relative proton density (M0), T1, and T2 is the inversion‐recovery TrueFISP sequence, consisting of an inversion pulse followed by a series of balanced steady‐state free precession acquisitions. Parameters can then be obtained from a mono‐exponential fit to the series of images. However, a segmented acquisition is usually necessary, which increases the total acquisition time considerably. The goal of this study is to obtain M0, T1, and T2 maps using a single‐shot acquisition, with T1 and T2 measurements in brain that are consistent with the published literature, with a 20‐fold speed improvement over the segmented approach, and at a clinically relevant spatial resolution. To this end, a single‐shot inversion‐recovery TrueFISP sequence was combined with a radial view‐sharing technique. The parameters M0, T1, and T2 were then obtained on a pixel‐wise basis from a three fit parameter to the signal evolution. The accuracy of this method for quantifying these parameters is demonstrated in vivo. In addition, further corrections to the quantification necessary owing to other experimental factors, namely magnetization transfer and imperfect slice profiles, were developed. Including additional scans necessary for these corrections in the measurement protocol, the required scan time is increased from approximately 6 to 18‐28 s per slice. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Compressed sensing reconstruction for whole‐heart imaging with 3D radial trajectories: A graphics processing unit implementation
Authors: Nam Seunghoon , Akçakaya Mehmet , Basha Tamer , Stehning Christian , Manning Warren J. , Tarokh Vahid , Nezafat Reza 
Published: March 2012

AbstractA disadvantage of three‐dimensional (3D) isotropic acquisition in whole‐heart coronary MRI is the prolonged data acquisition time. Isotropic 3D radial trajectories allow undersampling of k‐space data in all three spatial dimensions, enabling accelerated acquisition of the volumetric data. Compressed sensing (CS) reconstruction can provide further acceleration in the acquisition by removing the incoherent artifacts due to undersampling and improving the image quality. However, the heavy computational overhead of the CS reconstruction has been a limiting factor for its application. In this article, a parallelized implementation of an iterative CS reconstruction method for 3D radial acquisitions using a commercial graphics processing unit is presented. The execution time of the graphics processing unit‐implemented CS reconstruction was compared with that of the C++ implementation, and the efficacy of the undersampled 3D radial acquisition with CS reconstruction was investigated in both phantom and whole‐heart coronary data sets. Subsequently, the efficacy of CS in suppressing streaking artifacts in 3D whole‐heart coronary MRI with 3D radial imaging and its convergence properties were studied. The CS reconstruction provides improved image quality (in terms of vessel sharpness and suppression of noise‐like artifacts) compared with the conventional 3D gridding algorithm, and the graphics processing unit implementation greatly reduces the execution time of CS reconstruction yielding 34–54 times speed‐up compared with C++ implementation. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Prospective self‐gated nonenhanced magnetic resonance angiography of the peripheral arteries
Authors: Offerman Erik J. , Koktzoglou Ioannis , Glielmi Christopher , Sen Anindya , Edelman Robert R. 
Published: March 2012

AbstractMost nonenhanced MRA techniques for evaluating peripheral artery disease (PAD) require cardiac synchronization through physiological gating. Electrocardiographic gating is the most popular method for cardiac synchronization; however, it is subject to interference from switching magnetic field gradients and radiofrequency pulses. A method is described for self‐gated nonenhanced MRA that does not require the use of electrocardiographic gating. Imaging was prospectively triggered by detecting the acceleration of blood flow during systole with a reference‐less phase contrast navigator. The technique was implemented for nonsubtractive nonenhanced MRA using quiescent‐interval single‐shot MRA. The lower extremity peripheral arteries of eight healthy subjects were imaged using electrocardiographic‐, pulse‐, and self‐gated quiescent‐interval single‐shot. Self‐gated quiescent‐interval single‐shot triggered with 99% accuracy. There were no significant differences in relative contrast, contrast‐to‐noise ratio, or image quality between self‐gated and electrocardiographic‐gated quiescent‐interval single‐shot MRA (P > 0.05). Image quality with pulse gating was inferior. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Do the urinary bladder and large bowel interact, in sickness or in health?: ICI‐RS 2011
Authors: Malykhina Anna P. , Wyndaele Jean‐Jacques , Andersson Karl‐Erik , De Wachter Stefan , Dmochowski Roger R. 
Published: February 2012

AbstractNormal functioning of the urinary bladder and the distal gut is an essential part of daily physiological activity coordinated by the peripheral and central nervous systems. Pathological changes in one of these organs may induce the development of cross‐organ sensitization in the pelvis and underlie clinical co‐morbidity of genitourinary and GI dysfunctions. Experimental human and animal data suggest that the bladder and distal colon interact under both normal and pathological conditions, however, the directions of these interactions can change dramatically depending on the nature and duration of the applied stimuli. This review article aimed to summarize the clinical data on colon–bladder cross‐reflexes in healthy individuals, as well as in patients with co‐morbid disorders. It also discusses currently used animal models, experimental approaches, and suggested mechanisms of colon–bladder cross‐talk. Additionally, it provides an overview of the potential pharmacological targets to develop treatment options for patients with co‐morbid disorders. Presented work resulted from the discussion of colon/bladder interactions during “Think Tank 9” presentations at the International Consultation on Incontinence Research Society meeting held in Bristol, UK, 2011. Neurourol. Urodynam. 31:352–358, 2012. © 2012 Wiley Periodicals, Inc.
A consistent numerical scheme for self‐gravitating fluid dynamics
Authors: Colombeau M. 
Published: March 2012

AbstractIn this article, we present a numerical scheme for the 3‐D system of self‐gravitating fluid dynamics in the collisional case as well as in the non‐collisional case. Consistency in the sense of distributions is proved in 1‐D and in absence of pressure. In the other cases consistency is proved under the numerical assumptions of boundedness of the velocity field in the CFL condition and of boundedness of the gradient of the gravitation potential. In 2‐D and 3‐D, concentrations of matter in strings and points can cause a theoretical difficulty in the pressureless case although one observes that the scheme still works. The initial data are L∞ functions in velocity and L1 functions in density. Applications are given to numerical simulations of the role of dark matter and gravitational collapse in cosmology as well as Jeans theory. © 2012 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2013
Improved stability and error analysis for a class of local projection stabilizations applied to the Oseen problem
Authors: Knobloch Petr , Tobiska Lutz 
Published: March 2012

AbstractWe consider a class of local projection stabilizations with projection spaces defined on (possibly) overlapping sets applied to the Oseen problem. We prove that the underlying bilinear form satisfies an inf–sup condition with respect to a stronger norm than coercivity suggests. A modification of the stabilization of the convection allows an optimal estimation of the consistency error. A priori estimates in the stronger norm and in the L2 norm for the pressure are established. Discontinuous pressure approximations are included in the analysis. © 2012 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2013
Demographic diversity, value congruence, and workplace outcomes in acute care
Authors: Gates Michael G. , Mark Barbara A. 
Published: February 2012

AbstractNursing scholars and healthcare administrators often assume that a more diverse nursing workforce will lead to better patient and nurse outcomes, but this assumption has not been subject to rigorous empirical testing. In a study of nursing units in acute care hospitals, the influence of age, gender, education, race/ethnicity, and perceived value diversity on nurse job satisfaction, nurse intent to stay, and patient satisfaction were examined. Support was found for a negative relationship between perceived value diversity and all outcomes and for a negative relationship between education diversity and intent to stay. Additionally, positive relationships were found between race/ethnicity diversity and nurse job satisfaction as well as between age diversity and intent to stay. From a practice perspective, the findings suggest that implementing retention, recruitment, and management practices that foster a strong shared value system among nurses may lead to better workplace outcomes. © 2012 Wiley Periodicals, Inc. Res Nurs Health 35:265–276, 2012
Levetiracetam for busulfan‐induced seizure prophylaxis in children undergoing hematopoietic stem cell transplantation
Authors: Soni Sandeep , Skeens Micah , Termuhlen Amanda M. , Bajwa Rajinder P.S. , Gross Thomas G. , Pai Vinita 
Published: February 2012

AbstractAnti‐seizure prophylaxis is routinely utilized during busulfan administration for HSCT. We evaluated the feasibility and efficacy of levetiracetam in children undergoing HSCT. A total of 28 children and young adults received levetiracetam during HSCT and the outcomes and costs were compared to a historical, but similar cohort of 25 patients who had received fosphenytoin. Levetiracetam was well tolerated and was efficacious in preventing seizures. Cost of drug, administration, and monitoring were also similar among the two groups. Due to non‐induction of the hepatic cytochrome P450 enzymes, levetiracetam may lead to better dose assurance of busulfan in targeted dose regimens for HSCT. Pediatr Blood Cancer 2012;59:762–764. © 2012 Wiley Periodicals, Inc.