bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological mechanism of action of Lianhua Qingwen in the treatment of COVID‐19 and facial neuritis
Authors: Li Guang‐Jin , Hao Zhi‐Hong , Wang Han‐Jing , Wang Chen , Liu Da‐Wei , Chen Liang , Sun Yan 
Published: May 2024

AbstractObjectiveCoronavirus disease‐2019 (COVID‐19) can cause not only respiratory symptoms but also facial paralysis. Lianhua Qingwen (LHQW) has been reported to have therapeutic effects on COVID‐19 and facial neuritis (FN). We explored the potential mechanism of LHQW in the treatment of COVID‐19 and FN through a network‐pharmacology approach.MethodsActive compounds and relevant targets of LHQW were obtained from the databases of Traditional Chinese Medicine Systems Pharmacology Database, HERB, UniProt Knowledge Base, SwissADME, and Swiss Target Prediction. Disease targets of COVID‐19 and FN were acquired from Gene Cards. Database For Annotation, Visualization And Integrated Discovery and Metascape were used to search the biological functions of intersecting targets. After identifying the core targets and their corresponding ingredients, KEGG Mapper analyzes the localization of core targets in key pathways. AutoDock were employed to conduct molecular docking of the core targets and their corresponding ingredients.ResultsWe obtained four core genes: interleukin (IL)‐8, IL‐1B, IL‐6, and tumor necrosis factor (TNF)‐α. Database searching revealed the anti‐inflammatory and antiviral effects of LHQW may be related to the action of aleo‐emodin, hyperforin, kaempferol, luteolin, and quercetin on these four genes by regulating the pathways of IL‐17 and NOD‐like receptor. The molecular‐docking results of the four core targets and their corresponding active ingredients showed good binding activity between receptors and ligands.ConclusionsWe uncovered the active ingredients, potential targets, and biological pathways of LHQW for COVID‐19 and FN coinfection. Our data provide a theoretical basis for further exploration of the mechanism of action of LHQW in treatment of COVID‐19 and FN.
Evaluating satellite‐transmitter backpack‐harness effects on greater sage‐grouse survival and device retention in the Great Basin
Authors: Lundblad Carl G. , Anthony Christopher R. , Dungannon Tyler , Haab Kimberly A. , Schuyler Elizabeth M. , Sink Chelsea E. , Dugger Katie M. , Hagen Christian A. 
Published: May 2024

AbstractWildlife tracking studies have become ubiquitous in ecology and now provide previously unobtainable data regarding individual movement, vital rates, and population demographics. However, tracking devices can potentially reduce survival of study subjects, generating biases in the vital rates they seek to measure. Previous studies have found that greater sage‐grouse (Centrocercus urophasianus) fitted with Global Positioning System (GPS) tracking devices may experience reduced survival, relative to those tracked with traditional radio transmitters, and have documented skin abrasions and lacerations associated with typical backpack‐style GPS harnesses. We implemented an experimental study comparing survival and harness retention between 2 different backpack‐style GPS transmitter harnesses. We captured female sage‐grouse at 3 study sites in the northwest Great Basin of Oregon, Nevada, and California during 2019–2021. We fit each individual, following previously published recommendations, with either a standard backpack harness or a modified harness hypothesized to reduce skin abrasion and laceration. We used known‐fate models in Program MARK to model variation in survival and harness retention separately as a function of harness type, year, age, a linear effect of time, and the ratio of the device to individual body mass. Neither survival nor retention varied systematically by harness type, however retention decreased as a function of body mass ratio. We echo previous recommendations for standardized harness attachment protocols and studies designed to isolate and test potential mechanisms by which tracking devices and attachment methods might affect survival and well‐being of sage‐grouse and other tracked species.
Investigating Effort Estimation in a Large-Scale Agile ERP Transformation Program
Authors: Tobisch Franziska , Weigelt Karla , Philipp Pascal , Matthes Florian 
Published: May 2024

AbstractAdaptability is vital in today’s rapidly changing business environment, especially within IT. Agile methodologies have emerged to meet this demand and have thereby gained widespread adoption. While successful in smaller, co-located teams and low-criticality projects, applying agile methods in broader contexts poses challenges. Nevertheless, many organizations have started implementing agile methodologies in various areas, including large-scale Enterprise Resource Planning (ERP) projects. In contrast to traditional development, ERP projects involve deploying extensive integrated systems, are substantial in scale, and entail high risks and costs. Accurate predictions, like effort estimations, are crucial to meet customer satisfaction and deliver within plan and budget. However, estimating effort in an agile environment poses its own set of challenges. For instance, coordination efforts and dependencies among teams must be considered. While effort estimation is well-explored in classical software development and small-scale agile contexts, limited research exists in large-scale agile settings, particularly in projects rolling out and customizing standard ERP solutions. To address this gap, we conducted a case study on effort estimation in a large agile ERP transformation program, describing the estimation process, highlighting challenges, and proposing and evaluating mitigations.
Kaizen: Why is It so Difficult to Understand?
Authors: Shimada Go 
Published: May 2024

AbstractMuch existing research demonstrates the effectiveness of introducing kaizen to developing countries. The Japanese word “kaizen” is commonly translated into English as “continuous improvement” or simply “improvement.” However, its literal translation obscures important connotations that are difficult to translate. This chapter discusses the meaning of kaizen and why this seemingly simple term is challenging to comprehend not only for non-native speakers but also for Japanese readers. This chapter identified three reasons why kaizen is challenging to understand. First, there are two different origins of kaizen. One focuses on quality and productivity, and the other focuses on worker protection. In many cases, people often mix these two and make it difficult to understand. Second, the worker protection aspect of kaizen cannot be transferred directly to other countries as the management–labor relationship is different. Third, as the nature of kaizen is context specific, the entire logic is difficult to grasp. Improving the living standard of developing countries may require supplementing the implementation of the kaizen with additional assistance focused on safeguarding the well-being of workers.
Gauge SU(2)f flavour transfers
Authors: Darmé Luc , Deandrea Aldo , Mahmoudi Farvah 
Published: May 2024

Abstract
We introduce the idea of flavour transfer from a non-abelian horizontal SU(2)f flavour gauge group embedded in the Standard Model flavour structure. The new flavour vector bosons, in the mass range from the tens of GeV to multi-TeV, do not induce large flavour-changing neutral currents and meson oscillations, which usually provide the dominant constraints on this type of structure. Instead, the main constraints arise from “flavour-transfer” operators that we will study in detail. Several explicit models are presented and their prospects are thoroughly explored, including their phenomenology in the lepton and quark sectors at colliders and lower energy experiments. We perform a complete numerical fit in one such scenario, showing that LHC-based lepton-flavour violating searches are competitive with intensity frontier observables.
Die Behandlung der proximalen Humerusfraktur im Kindes- und im Jugendalter
Authors: Rüther Hauke , Strohm Peter C. , Schmittenbecher Peter , Schneidmüller Dorien ,   Sektion Kindertraumatologie (SKT) in der Deutschen Gesellschaft für Unfallchirurgie (DGU), Zwingmann Jörn 
Published: May 2024

Zusammenfassung
Hintergrund
Die proximale Humerusfraktur ist mit 0,45–2 % aller Frakturen eine relativ häufige Verletzung im Kindes- und im Jugendalter [2, 18]. Die Behandlung ist meistens konservativ, aber immer noch Gegenstand der wissenschaftlichen Diskussion [9, 12]. Neben der S1-LL gibt es unterschiedliche Empfehlungen zu Diagnostik und Behandlung dieser Fraktur in der Literatur.

Methodik
Im Rahmen des 10. Wissenschaftstreffens der SKT in der DGU wurden die vorhandenen Empfehlungen und die relevante bzw. aktuelle Literatur kritisch von einem Expertengremium diskutiert und ein Konsens formuliert. In diesen wurde ein Algorithmus zu Diagnostik, Therapie und Behandlung integriert.

Ergebnisse
Die Messung der Achsabweichung und Abkippung ist nicht „interobserver“ und „intraobserver reliable“ [3]. Die Altersgrenze, bis zu der eine vollständige Korrektur möglich ist, wurde auf 10 Jahre festgelegt, da sich ca. um dieses Alter das Korrekturpotenzial ändert. Zur Diagnostik wird die gut zentrierte Röntgenaufnahme in 2 Ebenen (true a.-p.- und Y‑Aufnahme ohne Thoraxanteile) als Standard festgelegt. Im Alter unter 10 Jahren kann jegliche Fehlstellung konservativ mittels Gilchrist-Verband für 2 bis 3 Wochen behandelt werden. Nur in Einzelfällen kann eine Operation z. B. bei starken Schmerzen oder notwendiger rascher Belastbarkeit indiziert sein. Über 10 Jahren sollte ein Ad-latus-Versatz über halbe Schaftbreite nicht toleriert werden. Aufgrund der Varianz der Messergebnisse kann eine Empfehlung zur operativen Versorgung in Abhängigkeit vom Ausmaß der Ad-axim-Dislokation nicht benannt werden. Orientierend gilt: Je größer die Dislokation und je näher das Kind am Fugenschluss ist, desto eher ist die operative Therapie indiziert. Die Entwicklung ist hier einzubeziehen. Den Goldstandard stellt die retrograde, radiale und unilaterale ESIN-Osteosynthese mittels 2 intramedullären Nägeln dar. Die Osteosynthese erfordert keine Ruhigstellung. Ein Verlaufsröntgen ist bei instabilen Frakturen ohne Osteosynthese nach einer Woche, sonst optional zur Dokumentation der Konsolidierung nach 4 (bis 6) Wochen, wenn z. B. die Sportfreigabe erteilt werden soll, sowie vor der Metallentfernung (12 Wochen) vorgesehen.

Schlussfolgerung
Empfehlungen zur Operationsindikation auf der Grundlage des Ausmaßes der Abkippung sind nicht reproduzierbar und erscheinen in Anbetracht der aktuellen Literatur schwierig [3, 9, 12]. Sinnvoller ist ein pragmatisches Vorgehen. Die Prognose der Fraktur erscheint unter Beachtung des erstellten Algorithmus so gut zu sein, dass in den meisten Fällen die Restitutio ad integrum erwartet werden kann.
Population pharmacokinetic, pharmacodynamic and efficacy modeling of SB12 (proposed eculizumab biosimilar) and reference eculizumab
Authors: Lee Hyuna , Park Jihye , Jang Hyerin , Lee So Jin , Kim Jungryul 
Published: May 2024

Abstract
Purpose
To describe, compare similarity of pharmacokinetic (PK), pharmacodynamic (PD) and efficacy of SB12 and reference eculizumab (ECU) and find clinically significant covariate relationships.

Methods
The PK, PD (terminal complement activity) and efficacy (LDH) data of SB12 and ECU were obtained from 289 subjects from phase I and phase III studies. One- and two-compartment PK models with first-order elimination were evaluated for SB12 and ECU. For PD and efficacy, both direct and indirect models were tested. The impact of covariates on PK, PD and efficacy parameters was assessed. Relationship between PK/PD and PD/efficacy was characterized. This modeling was performed using NONMEM version 7.4 (Icon Development Solutions, Ellicott City, MD, USA).

Results
The two-compartment model adequately described the PK of SB12 and ECU, and the subject’s weight was chosen as a clinically significant covariate affecting drugs’ clearance and central volume of distribution. Treatment group was not a significant covariate affecting clearance. The direct response model using inhibitory sigmoid Emax and sigmoid Emax relationship well described the PK/PD relationship and PD/efficacy relationship of SB12 and ECU, respectively. Through this modeling, the relationships between PK, PD and efficacy were characterized. There were no differences in PK, PD and efficacy parameters between SB12 and ECU in pooled populations of healthy subjects and paroxysmal nocturnal haemoglobinuria (PNH) patients.

Conclusion
The population modeling showed PK, PD and efficacy similarities between SB12 and ECU in pooled population of healthy subjects and PNH patients, supporting the totality of evidence on biosimilarity for SB12.
ZLR: a fast online authenticated encryption scheme achieving full security
Authors: Choi Wonseok , Hwang Seongha , Lee Byeonghak , Lee Jooyoung 
Published: May 2024

AbstractOnline authenticated encryption has been considered of practical relevance in light-weight environments due to low latency and constant memory usage. In this paper, we propose a new tweakable block cipher-based online authenticated encryption scheme, dubbed , and its domain separation variant, dubbed . and follow the Encrypt-Mix-Encrypt paradigm. However, in contrast to existing schemes using the same paradigm such as and , and enjoy n-bit security by using larger internal states with an efficient -like hashing algorithm. In this way, 2n-bit blocks are processed with only a single primitive call for hashing and two primitive calls for encryption and decryption, when they are based on an n-bit tweakable block cipher using n-bit (resp. 2n-bit) tweaks for (resp. ). Furthermore, they support pipelined computation as well as online nonce-misuse resistance. To the best of our knowledge, and are the first pipelineable tweakable block cipher-based online authenticated encryption schemes of rate-2/3 that provide n-bit security with online nonce-misuse resistance.
Gum Arabic-incorporated thymol/salicylic acid composite coatings control grey mould and brown rot in ‘Angeleno’ plums
Authors: Jenneker N. , Silué Y. , Julia Meitz-Hopkins J. C. , Lennox C. L. , Opara U. L. , Fawole O.A. 
Published: May 2024

AbstractThis study explores the antifungal efficacy of salicylic acid and thymol against Botrytis cinerea and Monilinia laxa, the main pathogens affecting stone fruit in South Africa. Antifungal properties of thymol and salicylic acid and their influence on the shelf life of “Angeleno” plums were investigated. Gum Arabic composite coatings infused with salicylic acid and thymol were further investigated, with fludioxonil as a positive control. In vitro, results showed complete inhibition (100%) of M. laxa and B. cinerea by thymol at 0.25 mM and 1 mM, respectively. Salicylic acid did not achieve complete pathogen inhibition The highest inhibition percentage, 38%, was recorded at 2 mM. In vivo assessments showed that while fludioxonil was highly effective, Gum Arabic coatings containing 2 mM and 4 mM salicylic acid closely matched its performance in decay prevention, reducing decay rates to 8%. Furthermore, Gum Arabic coatings significantly reduced shrivel incidence and maintained firmness of the plums over a 15 d shelf-life period. This study highlights thymol as a potent antimicrobial agent, especially against grey mould and brown rot in plums, while incorporating salicylic acid into GA coatings effectively reduces disease incidence without compromising fruit quality. These findings suggest a promising alternative to conventional fungicides in managing grey mould and brown rot in plums.
Free scalar field theory on a Sobolev space over a bounded interval
Authors: Barbero G. J. Fernando 
Published: May 2024

AbstractThis paper discusses several functional analytic issues relevant for field theories in the context of the Hamiltonian formulation for a free, massless, scalar field defined on a closed interval of the real line. The fields that we use belong to a Sobolev space with a scalar product. As we show this choice is useful because it leads to an explicit representation of the points in the fibers of the phase space (the cotangent bundle of the configuration space). The dynamical role of the boundary of the spatial manifold where the fields are defined is analyzed.
Epigenetic Insights Into Necrotizing Enterocolitis: Unraveling Methylation-Regulated Biomarkers
Authors: Tian Bowen , Xu Xiaogang , Li Lin , Tian Yan , Liu Yanqing , Mu Yide , Lu Jieting , Song Kai , lv Junjian , He Qiuming , Zhong Wei , Xia Huimin , Lan Chaoting 
Published: May 2024

Abstract
Necrotizing enterocolitis (NEC) is a multifactorial gastrointestinal disease with high morbidity and mortality among premature infants. This study aimed to identify novel methylation-regulated biomarkers in NEC intestinal tissue through multiomics analysis. We analyzed DNA methylation and transcriptome datasets from ileum and colon tissues of patients with NEC. We identify methylation-related differential genes (MrDEGs) based on the rule that the degree of methylation in the promoter region is inversely proportional to RNA transcription. These MrDEGs included ADAP1, GUCA2A, BCL2L14, FUT3, MISP, USH1C, ITGA3, UNC93A and IL22RA1. Single-cell data revealed that MrDEGs were mainly located in the intestinal epithelial part of intestinal tissue. These MrDEGs were verified through Target gene bisulfite sequencing and RT-qPCR. We successfully identified and verified the ADAP1, GUCA2A, IL22RA1 and MISP, primarily expressed in intestinal epithelial villus cells through single-cell data. Through single-gene gene set enrichment analysis, we found that these genes participate mainly in the pathological process of T-cell differentiation and the suppression of intestinal inflammation in NEC. This study enhances our understanding of the pathogenesis of NEC and may promote the development of new precision medicine methods for NEC prediction and diagnosis.
Evaluation of the Psychometric Properties of the Social Communication Questionnaire in Rural Kenya
Authors: Kipkemoi Patricia , Savage Jeanne E. , Gona Joseph , Rimba Kenneth , Kombe Martha , Mwangi Paul , Kipkoech Collins , Posthuma Danielle , Newton Charles R. J. C. , Abubakar Amina 
Published: May 2024

AbstractChildren can be reliably diagnosed with autism as early as 3 years of age, and early interventions are initiated. There is often a significant gap between the age of onset of symptoms (2–3 years) and diagnosis (8–10 years) in Africa. We conducted a study to validate the Social Communication Questionnaire (SCQ) as a screening instrument in a rural setting in Kenya. The study was conducted along the Kenyan Coast. Study participants included 172 children with a neurodevelopmental disorder (NDD) diagnosis (84 of which were autism) and 112 controls. Internal consistency was evaluated through the use of Cronbach’s alpha, confirmatory factor analysis (CFA) with maximum likelihood procedure to assess the conceptual model for the SCQ. Additionally, the sensitivity and specificity of cut-off scores using ROC analysis and item difficulties and discrimination quality using an IRT framework were also assessed. Factor analysis revealed an adequate fitting model for the three-factor DSM-IV-TR (root mean squared error of approximation (RMSEA) = 0.050; Comparative Fit Index (CFI) = 0.974; Tucker-Lewis Index (TLI) = 0.973) and two-factor DSM-5 factor structure (RMSEA = 0.050; CFI = 0.972; TLI = 0.974). The reliability coefficient alphas for the whole group for all items (Cronbach’s α = 0.90) and all three domains (Cronbach’s α = 0.68–0.84) were acceptable to excellent. The recommended cut-off score of 15 yielded 72% sensitivity and 100% specificity in the ASD group compared to the typically developing group. We provide early evidence of the adequate factor structure and good internal consistency of the SCQ. We also note that the recommended cut-off yielded sufficient predictive validity.
User-centric design of a 3D search interface for protein-ligand complexes
Authors: Diedrich Konrad , Ehrt Christiane , Graef Joel , Poppinga Martin , Ritter Norbert , Rarey Matthias 
Published: May 2024

AbstractIn this work, we present the frontend of GeoMine and showcase its application, focusing on the new features of its latest version. GeoMine is a search engine for ligand-bound and predicted empty binding sites in the Protein Data Bank. In addition to its basic text-based search functionalities, GeoMine offers a geometric query type for searching binding sites with a specific relative spatial arrangement of chemical features such as heavy atoms and intermolecular interactions. In contrast to a text search that requires simple and easy-to-formulate user input, a 3D input is more complex, and its specification can be challenging for users. GeoMine’s new version aims to address this issue from the graphical user interface perspective by introducing an additional visualization concept and a new query template type. In its latest version, GeoMine extends its query-building capabilities primarily through input formulation in 2D. The 2D editor is fully synchronized with GeoMine’s 3D editor and provides the same functionality. It enables template-free query generation and template-based query selection directly in 2D pose diagrams. In addition, the query generation with the 3D editor now supports predicted empty binding sites for AlphaFold structures as query templates. GeoMine is freely accessible on the ProteinsPlus web server (https://proteins.plus).
The Pursuit of Subjective Well-Being Through Financial Well-Being, Relationship Quality, and Spiritual Well-Being: A Configuration Approach with Fuzzy-Set Qualitative Comparative Analysis (fsQCA)
Authors: Jalal Ahamed A. F. M. 
Published: May 2024

AbstractIndividuals’ subjective well-being is influenced by their financial well-being, family relationship quality, spiritual well-being, gender, and age. However, our knowledge of potential associations between these factors is limited, especially in non-western developing countries. Further, human thinking’s complexity, interconnectedness, and asymmetry fit nicely with subjective well-being conceptualizations. Therefore, this research is one of the very first studies from a typical Asian country that conceptualizes subjective well-being asymmetrically. The primary objective of this study was to determine which combinations of these factors resulted in higher or lower subjective well-being. We used a self-administered questionnaire to survey 250 married working people in Bangladesh’s capital city. The factor combinations are identified with a fuzzy-set qualitative comparative analysis (fsQCA). Despite not finding any necessary condition for high or low subjective well-being, the analysis identifies two equifinal combinations of high subjective well-being and four combinations of low subjective well-being. In Asian cultures, where family bonds and spiritual well-being are feared to be declining, the combination of identified configurations re-emphasizes the importance of family relationship quality and spiritual well-being. Using a configurational approach, the findings contribute to the literature on subjective well-being and family relationships by explaining how different combinations of factors determine an individual's well-being. Additionally, this has important implications for policymakers and society as a whole.