bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary sinonasal chondroid chordoma in a pediatric patient: a diagnostic challenge
Authors: Mann Prachi , Arya Ayush , Disawal Amit , Anand Aarti 
Published: June 2024

Abstract
Background
Chordomas are rare, malignant tumors typically centered in midline structures such as the clivus and sacrum, with peak prevalence in the fourth decade. Clival chordomas may secondarily extend to involve the nasopharynx and nasal cavity; however, primary extra-osseous chordomas are even more uncommon. We present an unusual case of a primary sinonasal chondroid chordoma arising from the maxillary sinus in a 5-year-old child. This is the second case of primary sinonasal chordoma reported in the literature so far, after Tao ZZ et al. and the first case of the chondroid variant.

Case presentation
A 5-year-old male presented with right-sided nasal obstruction, nasal congestion, and snoring for 2 months. Physical examination showed a reddish polypoidal mass in the right nasal cavity obstructing the choana with nasal septal deviation toward left side. Radiological examination with CT confirmed the presence of a well-defined, heterogeneously hyperdense lobulated mass in right maxillary sinus extending into right nasal cavity with intralesional coarse calcifications. MRI revealed expansile solid altered signal intensity mass, which appears to be isointense on T1-weighted imaging (T1WI) and heterogeneously hyperintense on T2-weighted imaging (T2WI) with a heterogeneous honeycomb pattern of enhancement. Differentials considered were rhabdomyosarcoma, nasopharyngeal carcinoma, and neuroblastoma metastasis. However, the lesion was pathologically proven as a chondroid chordoma. No association with skull base or clival lesion was found on review.

Conclusions
Primary sinonasal chordomas are rare in occurrence but should be considered a differential for sinonasal masses in the presence of characteristic MRI features, despite their uncommon location.
Mini-MEndR: a miniaturized 96-well predictive assay to evaluate muscle stem cell-mediated repair
Authors: Gulati Nitya , Davoudi Sadegh , Xu Bin , Rjaibi Saifedine T. , Jacques Erik , Pham Justin , Fard Amir , McGuigan Alison P. , Gilbert Penney M. 
Published: June 2024

Abstract
Background
Functional evaluation of molecules that are predicted to promote stem cell mediated endogenous repair often requires in vivo transplant studies that are low throughput and hinder the rate of discovery. To offer greater throughput for functional validation studies, we miniaturized, simplified and expanded the functionality of a previously developed muscle endogenous repair (MEndR) in vitro assay that was shown to capture significant events of in vivo muscle endogenous repair.

Methods
The mini-MEndR assay consists of miniaturized cellulose scaffolds designed to fit in 96-well plates, the pores of which are infiltrated with human myoblasts encapsulated in a fibrin-based hydrogel to form engineered skeletal muscle tissues. Pre-adsorbing thrombin to the cellulose scaffolds facilitates in situ tissue polymerization, a critical modification that enables new users to rapidly acquire assay expertise. Following the generation of the 3D myotube template, muscle stem cells (MuSCs), enriched from digested mouse skeletal muscle tissue using an improved magnetic-activated cell sorting protocol, are engrafted within the engineered template. Murine MuSCs are fluorescently labeled, enabling co-evaluation of human and mouse Pax7+ cell responses to drug treatments. A regenerative milieu is introduced by injuring the muscle tissue with a myotoxin to initiate endogenous repair “in a dish”. Phenotypic data is collected at endpoints with a high-content imaging system and is analyzed using ImageJ-based image analysis pipelines.

Results
The miniaturized format and modified manufacturing protocol cuts reagent costs in half and hands-on seeding time ~ threefold, while the image analysis pipelines save 40 h of labour. By evaluating multiple commercially available human primary myoblast lines in 2D and 3D culture, we establish quality assurance metrics for cell line selection that standardizes myotube template quality. In vivo outcomes (enhanced muscle production and Pax7+ cell expansion) to a known modulator of MuSC mediated repair (p38/β MAPK inhibition) are recapitulated in the miniaturized culture assay, but only in the presence of stem cells and the regenerative milieu.

Discussion
The miniaturized predictive assay offers a simple, scaled platform to co-investigate human and mouse skeletal muscle endogenous repair molecular modulators, and thus is a promising strategy to accelerate the muscle endogenous repair discovery pipeline.
A Hybrid Type III Effectiveness-Implementation Trial to Optimize Medication Safety With Oral Antitumor Therapy in Real-World: The AMBORA Competence and Consultation Center
Authors: Cuba Lisa , Dürr Pauline , Gessner Katja , Häcker Babette , Fietkau Rainer , Siebler Jürgen , Pavel Marianne , Neurath Markus F. , Berking Carola , Wullich Bernd , Brückl Valeska , Beckmann Matthias W. , Fromm Martin F. , Dörje Frank 
Published: June 2024

PURPOSE Implementation science endeavors to facilitate the translation of evidence-based research into clinical routine. The clinical pharmacological/pharmaceutical care program evaluated in the randomized AMBORA trial on medication safety with oral antitumor therapeutics (OAT) optimizes care delivery and provides significant benefits for patients, treatment teams, and health care systems. Thus, we aimed to investigate the implementation of this care program within the AMBORA Competence and Consultation Center (AMBORA Center). METHODS The AMBORA Center within a University Comprehensive Cancer Center offered several services (eg, patient consultations) and was evaluated according to the RE-AIM framework. This multicenter hybrid type III trial focused on implementation outcomes (eg, patient recruitment, referring units, evaluation of services) while concurrently investigating effectiveness (eg, side effects, medication errors). Quantitative and qualitative assessments were combined. RESULTS The AMBORA Center conducted over 800 consultations with 420 patients in seven institutions. The primary end point of counseling 70% of patients treated with OAT was not reached. Patients were referred by 15 treatment units compared with 11 units in the AMBORA trial. On the basis of heterogeneous referral rates and characteristics across the institutions, barriers and facilitators of the implementation process were derived. Several survey results (eg, stakeholder interviews, online/paper-based questionnaires) reflected a high appreciation of services by patients and health care professionals. The severity of 60.1% (178 of 296) of detected side effects improved, and 86.3% (297 of 344) of medication errors were resolved. CONCLUSION Despite not reaching the primary implementation outcome, the AMBORA Center included more treatment units and demonstrated patient benefit of the AMBORA care program by meeting all effectiveness outcomes. We outlined quantitative and qualitative implementation characteristics to enhance outreach and foster further dissemination of centers to optimize medication safety with OAT.
Predictive Impact of Tumor Mutational Burden on Real-World Outcomes of First-Line Immune Checkpoint Inhibition in Metastatic Melanoma
Authors: Andrews Miles C. , Li Gerald , Graf Ryon P. , Fisher Virginia A. , Mitchell Jerry , Aboosaiedi Ali , O'Rourke Harriet , Shackleton Mark , Iddawela Mahesh , Oxnard Geoffrey R. , Huang Richard S.P. 
Published: June 2024

PURPOSE The choice of threshold and reliability of high tumor mutational burden (TMB) to predict outcomes and guide treatment choice for patients with metastatic melanoma receiving first-line immune checkpoint inhibitor (ICI) therapy in the real world is not well known. METHODS Using a deidentified nationwide (US-based) melanoma clinicogenomic database, we identified a real-world cohort of patients with metastatic melanoma (N = 497) who received first-line monotherapy anti–PD-1 (n = 240) or dual anti–PD-1 and anti–CTLA-4 ICI (n = 257) and had a tissue-based comprehensive genomic profiling test TMB score. RESULTS TMB-high (TMB-H; ≥10 mutations per megabase [muts/Mb], n = 352, 71%) was independently predictive of superior real-world progression-free survival and overall survival versus TMB-low (<10 mut/Mb, n = 145, 29%) in both mono ICI (hazard ratio [HR], 0.45 [95% CI, 0.32 to 0.63]; P < .001; HR, 0.61 [95% CI, 0.41 to 0.90]; P = .01, respectively) and dual ICI (HR, 0.67 [95% CI, 0.49 to 0.90]; P = .009; HR, 0.61 [95% CI, 0.42 to 0.88]; P = .007, respectively) patients. Dual ICI offered no significant advantage in BRAFwt patients and unexpectedly demonstrated greatest benefit in the TMB 10-19 mut/Mb group, identifying a TMB-very high (≥20 mut/Mb, n = 247, 50%) BRAFmut patient subgroup for whom mono ICI may be preferable. CONCLUSION TMB-H predicts superior outcomes on ICI while coassessment of BRAF status and TMB may inform first-line regimen choice.
Serial Cell-Free DNA Sequencing in ROS1 Fusion–Positive Lung Cancers During Treatment With Entrectinib
Authors: Choudhury Noura J. , Jun Woo Hyung , Chen Monica , Shah Ronak , Donoghue Mark , Berger Michael , Drilon Alexander 
Published: June 2024

PURPOSE Patients with metastatic ROS1 fusion–positive non–small cell lung cancer (NSCLC) are effectively treated with entrectinib, a multikinase inhibitor. Whether serial targeted gene panel sequencing of cell-free DNA (cfDNA) can identify response and progression along with mechanisms of acquired resistance to entrectinib is underexplored. METHODS In patients with ROS1 fusion–positive NSCLC, coclinical trial plasma samples were collected before treatment, after two cycles, and after progression on entrectinib (global phase II clinical trial, ClinicalTrials.gov identifier: NCT02568267 ). Samples underwent cfDNA analysis using MSK-ACCESS. Variant allele frequencies of detectable alterations were correlated with objective response per RECIST v1.1 criteria. RESULTS Twelve patients were included, with best response as partial response (n = 9, 75%), stable disease (n = 2, 17%), and progressive disease (PD; n = 1, 8%). A ROS1 fusion was variably detected in cfDNA; however, patients without a ROS1 fusion in cfDNA had no other somatic alterations detected, indicative of possible low cfDNA shedding. Clearance of the enrolling ROS1 fusion or concurrent non- ROS1 alterations ( TP53, CDH1, NF1, or ARID1A mutations) was observed in response to entrectinib therapy. Radiologic PD was accompanied by redemonstration of a ROS1 fusion or non- ROS1 alterations. On-target resistance was rare; only one patient acquired ROS1 G2032R at the time of progression. Several patients acquired new off-target likely oncogenic alterations, including a truncating alteration in NF1. CONCLUSION Serial cfDNA monitoring may complement radiographic assessments as determinants of response and resistance to entrectinib in ROS1 fusion–positive lung cancers in addition to detecting putative resistance mechanisms on progression.
Perioperative Primary Care Utilization and Postoperative Readmission, Emergency Department Use, and Mortality in Older Surgical Patients
Authors: Ron Donna , Abess Alexander T. , Boone Myles D. , Martinez-Camblor Pablo , Deiner Stacie G. 
Published: June 2024

BACKGROUND:
Postdischarge primary care follow-up is associated with lower readmission rates after medical hospitalizations. However, the effect of primary care utilization on readmission has not been studied in surgical patients.

METHODS:
Retrospective cohort study of Medicare beneficiaries aged 65 and older undergoing major inpatient diagnostic or therapeutic procedures (n = 3,552,906) from 2017 through 2018, examining the association between postdischarge primary care visits within 14 days of discharge (primary exposure), and Annual Wellness Visits in the year prior (secondary exposure), with 30-day unplanned readmission (primary outcome), emergency department visits, and mortality (secondary outcomes).

RESULTS:
Overall, 9.5% (n = 336,837) had postdischarge visits within 14 days, 2.9% (n = 104,571) had Annual Wellness Visits in the year preceding the procedure, 9.5% (n = 336,401) were readmitted, 9% (n = 319,054) had emergency department visits, and 0.6% (n = 22,103) of the cohort died within 30 days. Our fully adjusted propensity-matched proportional hazards Cox regression analysis showed that postdischarge visits were associated with a 5% lower risk of readmission (hazard ratio [HR], 0.95, 95% confidence interval [CI], 0.93–0.97), 43% higher risk of emergency department use (HR, 1.43, 95% CI, 1.40–1.46) and no difference in mortality risk (HR, 0.98, 95% CI, 0.90–1.06), compared with not having a visit within 14 days of discharge. In a separate set of regression models, Annual Wellness Visits were associated with a 9% lower risk of readmission (HR, 0.91, 95% CI, 0.88–0.95), 45% higher risk of emergency department utilization (HR, 1.45, 95% CI, 1.40–1.49) and an 18% lower mortality risk (HR, 0.82, 95% CI, 0.75–0.89) compared with no Annual Wellness Visit in the year before the procedure.

CONCLUSIONS:
Both postdischarge visits and the Medicare Annual Wellness Visit appear to be extremely underutilized among the older surgical population. In those patients who do utilize primary care, compared with propensity-matched patients who do not, our study suggests primary care use is associated with modestly lower readmission rates. Prospective studies are needed to determine whether targeted primary care involvement can reduce readmission.
If “Everything Is Mapu”
Authors: Madarieta Ethan 
Published: June 2024

Abstract
Chile has created its national cohesion and territorial assertion of sovereignty through a colonial metonymic operation whereby the removal of the Indigenous body, or part of this body, is possession of the land; whereby the Black body is instrumentalized as an extension of settler occupation, inhabitation, and Indigenous elimination. This operation is based on the “associative matter” or qualifying characteristics of a metonymic relation within settler logics that performatively call into being both “territory” and “nation.” This essay argues that this is an ontoepistemological substitution and the foundation on which the current 1980 Chilean constitution is based, and on which the majority rejected the proposed 2022 constitution. The essay critiques both the 1980 and the recently rejected constitutions through consideration of what a Mapuche cosmological conception of land-as-mapu, of mapu as everything rather than as propertied resource, might mean for demolishing the land and body logics of the settler-colonial state that continue to devastate ecological relations through the dispossession and elimination of Indigenous and Black peoples.
A Buddhist Mindfulness View of Paradox: Silence and Skepticism of Language to Dismantle Paradoxes
Authors: Song Hee-Chan 
Published: June 2024

This study explores how Buddhist mindfulness as a self-reflective practice helps individuals respond to a paradox and ultimately dismantle it. To deeply immerse myself into this context, I conducted a nine-month ethnographic fieldwork in three Korean Buddhist temples that confront the paradox between the need for financial resources and spiritual values that disavow money. The findings show a series of cognitive mechanisms that reveal multiple roles of mindfulness, manifested as silence and skepticism of language. First, the monastic environment enables monks to become familiar with a life of silence that turns their attention to the inner mind from the external-empirical world. The silence serves as a mental buffer when monks switch between their sacred role and their business role. Over time, deep silence directs them to skepticism of language that triggers doubt on preexisting linguistic categories, boundaries, and separations. When the preexisting linguistic categories finally disappear in their mind, monks no longer rely on any differentiating or integrating tactic to navigate their paradox. In other words, they no longer perceive a paradox, which means the paradox has disappeared from their life. These cognitive mechanisms construct the monks’ worldview on contradictions, conflicts, and dualities, leading them from the experience of paradox to a unique mental state, the nonexperience of paradox. Integrating this mental state and the worldview of Buddhist monks with paradox research, this study theorizes a Buddhist mindfulness view of paradox. Funding: This work was supported by Chulalongkorn University.
Asset sharing in the healthcare sector: part one—impact on perceptions of service quality and intention to use the service again
Authors: Rothert-Schnell Caroline , Böddeker Sebastian , Walsh Gianfranco 
Published: June 2024

Background/Aims The sharing economy comprises three main actors: sharing platforms, asset providers and end users (consumers). These actors arguably possess decision-making autonomy and make sharing-related decisions on their own behalf, but the growing prevalence of asset sharing in the healthcare sector implies the possibility of heteronomous, provider-driven decisions. This article reports the findings of the first part of a two-part study providing insights into the unintended effects of sharing healthcare assets when the sharing decision is made by the healthcare service provider, not the service user. Methods Building on reactance theory, this study used an experimental scenario-based design. A total of 398 participants (all members of the general public) were randomly assigned to three groups and given a scenario involving a consultation with a physician. In one scenario, participants were told they would undergo an operation in a theatre used solely by the physician's practice, while in the other two scenarios the theatre was shared with either five or 10 other practices. Participants were asked about their perceptions of the physician and whether they would use their services again, ranking agreement to items on a 7-point Likert scale. Regression analyses were performed to assess the relationships between asset sharing conditions, participants’ perception of the quality of the service and the intention to use the service again. Results Healthcare asset sharing was significantly and negatively associated with perceived service quality (b=−0.54; P=0.000). While perceived service quality had a significant positive effect on intention to use the service again (b=0.91; P<0.001), none of the sharing or non-sharing conditions had a significant direct effect on intention to use the service again. This indicates that perceived service quality had a full mediating effect on the relationship between asset sharing and intention to use the service again. Conclusions Sharing healthcare assets could negatively affect patients’ intention to use the service again by reducing the perceived quality of the service. Healthcare organisations should work to reduce the impact of asset sharing on perceived quality in order to prevent a negative effect on patient-related outcomes, such as satisfaction and intention to use the service again.
Examining the causal relationship between sex hormone-binding globulin (SHBG) and infertility: A Mendelian randomization study
Authors: Ma Hanghao , Chen Yan 
Published: June 2024

Background
The causal relationship between sex hormone-binding globulin (SHBG) and infertility has remained unclear. Thus, we used Mendelian randomization (MR) to investigate this relationship.

Methods
Risk factors for SHBG were extracted from European individuals within the UK Biobank using single-nucleotide polymorphism (SNP) data. Summary-level data for infertility outcomes were obtained from the FinnGen dataset. The causal relationship between SHBG and infertility was examined using inverse variance weighted, weighted model, weighted median, and MR-Egger regression analyses. Additionally, Cochran’s Q test and Egger intercept tests were used to confirm the heterogeneity and pleiotropy of identified instrumental variables (IVs).

Results
Our findings revealed a significant negative association between sex hormone-binding globulin (SHBG) levels and infertility, particularly with anovulation, a specific form of female infertility. However, SHBG did not exert a causal impact on male infertility or on female infertility of tubal origin.

Conclusions
SHBG expression offers protection against the development of certain types of female infertility, suggesting it is a potential therapeutic target for infertility.
Strength assessment of fiberglass layer configurations in FRP ship materials from yard practices using a statistical approach
Authors: Ismail Abdi , Ma’ruf Buana , Zubaydi Achmad , Octavanny Made Ayu Dwi , Ginta Turnad Lenggo 
Published: June 2024

Abstract
Fiberglass Reinforced Polymer (FRP) is a type of composite extensively used in small boats in Indonesia. Most FRP research focuses on general applications and research on FRP materials is not aligned with actual yard practices in lamination. This study examined the mechanical characteristics of marine-grade FRP composites applied to ships, considering fiberglass layer configurations that conform to yard practices and their compliance analysis with several international classification rules. Samples from Bojonegara and Makassar 3 met the criteria of the Indonesian Classification Bureau, Korean Register, and American Bureau of Shipping rules for tensile and bending strength and have the best specific strength. Analysis of Variance showed that the differences in fiberglass layer configurations had a significant impact on tensile and bending strength. Grouping using Tukey Simultaneous Tests indicated that samples with four or five layers showed tensile and bending strength that were not significantly different statistically. The Unsaturated Polyester Resin brand had a considerable impact on tensile strength but a less pronounced effect on bending strength. Sample Bojonegara and Makassar 3 can be recommended for practitioners in FRP shipyards as they have met the requirements of international regulations.
Some new fixed point theorems of α-partially nonexpansive mappings
Authors: Shukla Rahul 
Published: June 2024

Abstract
In this paper, we introduce a new class of nonlinear mappings and compare it to other classes of nonlinear mappings that have appeared in the literature. We establish various existence and convergence theorems for this class of mappings under different assumptions in Banach spaces, particularly Banach spaces with a normal structure. In addition, we provide examples to substantiate the findings presented in this study. We prove the existence of a common fixed point for a family of commuting

α

\alpha

-partially nonexpansive self-mappings. Furthermore, we extend the results reported by Suzuki (Fixed point theorems and convergence theorems for some generalized nonexpansive mappings, J. Math. Anal. Appl. 340 (2008), no. 2, 1088–1095), Llorens-Fuster (Partially nonexpansive mappings, Adv. Theory Nonlinear Anal. Appl. 6 (2022), no. 4, 565–573), and Dhompongsa et al. (Edelstein’s method and fixed point theorems for some generalized nonexpansive mappings, J. Math. Anal. Appl. 350 (2009), no. 1, 12–17). Finally, we present an open problem concerning the existence of fixed points for

α

\alpha

-partially nonexpansive mappings in the context of uniformly nonsquare Banach spaces.