bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bringing Employees Closer: The Effect of Proximity on Communication When Teams Function under Time Pressure
Authors: Chong Darrel S. F. , van Eerde Wendelien , Rutte Christel G. , Chai Kah Hin 
Published: January 2012

Some studies have assumed close proximity to improve team communication on the premise that reduced physical distance increases the chance of contact and information exchange. However, research showed that the relationship between team proximity and team communication is not always straightforward and may depend on some contextual conditions. Hence, this study was designed with the purpose of examining how a contextual condition like time pressure may influence the relationship between team proximity and team communication. In this study, time pressure was conceptualized as a two‐dimensional construct: challenge time pressure and hindrance time pressure, such that each has different moderating effects on the proximity–communication relationship.The research was conducted with 81 new product development (NPD) teams (437 respondents) inWesternEurope (Belgium,England,France,Germany, and theNetherlands). These teams functioned in short‐cycled industries and developed innovative products for the consumer, electronic, semiconductor, and medical sectors. The unit of analysis was a team, which could be from a single‐team or a multiteam project. Results showed that challenge time pressure moderates the relationship between team proximity and team communication such that this relationship improves for teams that experience high rather than low challenge time pressure. Hindrance time pressure moderates the relationship between team proximity and team communication such that this relationship improves for teams that experience low rather than high hindrance time pressure.Our findings contribute to theory in two ways. First, this study showed that challenge and hindrance time pressure differently influences the benefits of team proximity toward team communication in a particular work context. We found that teams under high hindrance time pressure do not benefit from close proximity, given the natural tendency for premature cognitive closure and the use of avoidance coping tactics when problems surface. Thus, simply reducing physical distances is unlikely to promote communication if motivational or human factors are neglected. Second, this study demonstrates the strength of the challenge–hindrance stressor framework in advancing theory and explaining inconsistencies. Past studies determined time pressure by considering only its levels without distinguishing the type of time pressure. We suggest that this study might not have been able to uncover the moderating effects of time pressure if we had conceptualized time pressure in the conventional way.
Strategic Alignment and New Product Development: Drivers and Performance Effects
Authors: Acur Nuran , Kandemir Destan , Boer Harry 
Published: January 2012

Strategic alignment is widely accepted as a prerequisite for a firm's success, but insight into the role of alignment in, and its impact on, the new product development (NPD) process and its performance is less well developed. Most publications on this topic either focus on one form of alignment or on one or a limited set of NPD performance indicators. Furthermore, different and occasionally contradictory findings have been reported.NPD scholars have long argued for the importance of fit between context and NPD activities. However, this body of literature suffers from the same weakness: most publications have a limited scope and the findings are not always consistent with results reported previously. This study addresses these deficiencies by examining (1) the effects of various internal and external factors on different forms of alignment, and (2) the effects of these forms of alignment on a set of NPD performance indicators.Strategic planning and innovativeness appear to affect technological, market, and NPD‐marketing alignment positively. Environmental munificence is negatively associated with NPD‐marketing alignment, but has no effect on the two other forms of alignment. Technological change has a positive effect on technological alignment, a negative effect on NPD‐marketing alignment, but no effect on market alignment. These findings suggest that internal capabilities are more likely to be associated with the development of strategic alignment than environmental factors are. Furthermore, technological and NPD‐marketing alignment affect NPD performance positively, while market alignment does not have any significant performance effects.
Perspective: Ranking of the World's Top Innovation Management Scholars and Universities
Authors: Yang Pianpian , Tao Lei 
Published: January 2012

This paper extends Jeffrey Thieme's article “The World's Top Innovation Management Scholars and Their Social Capital,” published in 2007 in J
P
I
M, in which he made a ranking of the world's top innovation managements scholars. This paper makes four contributions. First, this paper includes data on innovation management from articles published in two leading innovation management journals and eight top management and marketing journals during past 20 years (1991–2010). Second, this paper classifies 1229 articles into 29 categories, revealing hot topics and future research directions. Third, this paper ranks 1718 innovation management scholars over a period of 20 years from 1991 to 2010. Fourth, this is the first time that 625 universities have been ranked in terms of their current faculty research capabilities in the field of innovation management.The empirical data from the past 20 years show that the world's top 10 innovation management scholars are: Michael Song (University of Missouri‐Kansas City), Roger J. Calantone (Michigan State University), Erik Jan Hultink (Delft University of Technology), Mark E. Parry (University of Missouri‐Kansas City), Kwaku Atuahene‐Gima (China Europe International Business School), C. Anthony Di Benedetto (Temple University), Abbie Griffin (University of Utah), William E. Souder (Retired), Barry L. Bayus (University of North Carolina at Chapel Hill), and Christoph H. Loch (INSEAD).The world's top 10 innovation management universities are: University of Missouri‐Kansas City, Massachusetts Institute of Technology, Michigan State University, INSEAD, Harvard University, University of Pennsylvania, Northeastern University, Texas A&M University, Stanford University, and Delft University of Technology.
Eating disorders and oral health: a matched case–control study
Authors: Johansson Ann‐Katrin , Norring Claes , Unell Lennart , Johansson Anders 
Published: January 2012

Johansson A‐K, Norring C, Unell L, Johansson A. Eating disorders and oral health: a matched case–control study.

Eur J Oral Sci 2012; 120: 61–68. © 2012 Eur J Oral SciThe aim was to compare the oral health status of patients with eating disorders (EDs), with sex‐ and age‐matched controls, with a view to identify self‐reported and clinical parameters that might alert the dental healthcare professional to the possibility of EDs. All patients who entered outpatient treatment in an ED clinic during a 12‐month period were invited to participate. Of 65 ED patients who started psychiatric/medical treatment, 54 agreed to participate. Eating disorder patients and controls answered a questionnaire and underwent dental clinical examinations. Multivariate analysis identified significantly higher ORs for ED patients to present dental problems (OR = 4.1), burning tongue (OR = 14.2), dry/cracked lips (OR = 9.6), dental erosion (OR = 8.5), and less gingival bleeding (OR = 1.1) compared with healthy controls. Sensitivity and specificity for the correct classification of ED patients and controls using the five variables was 83% and 79%, respectively. The ED patients with vomiting/binge eating behaviors reported worse perceived oral health (OR = 6.0) and had more dental erosion (OR = 5.5) than those without such behavior. In ED patients with longer duration of the disease, dental erosion was significantly more common. In conclusion, oral health problems frequently affect ED patients, and this needs to be considered in patient assessment and treatment decisions.
Hypoxia triggers a HIF‐mediated differentiation of peripheral blood mononuclear cells into osteoclasts
Authors: Dandajena T. C. , Ihnat M. A. , Disch B. , Thorpe J. , Currier G. F. 
Published: January 2012

Dandajena T. C., Ihnat M. A., Disch B., Thorpe J., Currier G. F. Hypoxia triggers a HIF‐mediated differentiation of peripheral blood mononuclear cells into osteoclasts.  Orthod Craniofac Res 2012;15:1–9 © John Wiley & Sons A/SStructured AbstractBackground –  The source and mechanisms leading to osteoclast (OC) generation during tooth movement are not clearly understood. We hypothesized that during tooth movement, OC differentiate from peripheral blood mononuclear cells (PBMNC) downstream of the global hypoxia‐inducible transcription factor hypoxia‐inducible factor (HIF)‐1α.Objective –  The objective of this study was to demonstrate up‐regulation of OC growth factors from osteoblasts (OB) and subsequent conversion of PBMNC into functional OC under hypoxic stress.Material and Methods –  Human primary PBMNC were cocultured with/without OB and subjected to either hypoxia (2.5% O2) or normoxia (21% O2) over 14 days. Levels of HIF, vascular endothelial growth factor (VEGF) and receptor activator for nuclear factor kappa‐β ligand (RANKL) were measured. Conversion of PBMNC into OC was measured using resorption and TRAP assays.Results –  Functional OC were only observed in response to hypoxia during coculture of PBMNC and OB and only after up‐regulation of HIF, VEGF and RANKL in the hypoxic conditions. YC‐1, a HIF inhibitor, reduced OC formation in response to hypoxia.Conclusion –  Hypoxia triggers the differentiation of PBMNC into functional OC in the presence of OB in a HIF‐dependent manner as would occur during orthodontic loading of the periodontal ligament space.
Lycorine Derivatives Against Trichomonas vaginalis
Authors: Giordani Raquel B. , Junior Celso O. R. , de Andrade Jean P. , Bastida Jaume , Zuanazzi Jose A. S. , Tasca Tiana , de Almeida Mauro V. 
Published: January 2012

Six lycorine derivatives were prepared, characterized, and evaluated for their in vitro anti‐Trichomonas vaginalis activity. Compounds bearing an acetyl (2), lauroyl (3), benzoyl (4 and 5), and p‐nitrobenzoyl (6 and 7) groups were synthesized. The best activity was achieved with lycorine esterified at C‐2 position with lauroyl group. Preliminary structure–activity relationship points that unprotected OH group at C‐1 and C‐2 is not necessary to the antiparasitic activity, and none of the derivative was less active than lycorine. The lycorine structural requisites required to kill this amitochondriate cell seem to be different in comparison with the derivatives most active against other parasites and tumor cell lines, both mitochondriated cells. This result is an important contribution with our ongoing studies regarding the mechanism of action of the Amaryllidaceae alkaloids on T. vaginalis cell death opening a new perspective to optimize this innovative pharmacological potential.
The Association between Depression, Suicidal Ideation, and Stroke in a Population-Based Sample
Authors: Fuller-Thomson Esme , Tulipano Maressa J. , Song Michael 
Published: January 2012

Background Stroke survivors often experience poststroke depression and suicidal ideation. Purpose to determine the frequency and odds ratio of depression and suicidal ideation among stroke survivors, in comparison to those without stroke, and to identify demographic factors associated with elevated odds of depression and suicidal ideation among stroke survivors. Methods Secondary analysis of the Canadian Community Health Survey, a population-based sample. Logistic regressions of depression and suicidal ideation were conducted. Results Among those with stroke, 7.4% were depressed, in comparison to 5.2% of those without stroke ( P = 0.01). The cumulative lifetime frequency of suicidal ideation was 15.2% among stroke survivors in comparison to 9.4% of those without stroke ( P #< 0.001). After adjusting for sociodemographic factors, stroke survivors had twice the odds of depression and suicidal ideation in comparison to those without stroke (odds ratio = 2.21; 95% confidence interval = 1.61, 3.04 and odds ratio = 2.07; 95% confidence interval = 1.68, 2.55, respectively). When functional limitations and activities of daily living limitations were added to the analyses, there was a substantial decrease in the associations between stroke and depression (odds ratio = 1.29; confidence interval = 0.93, 1.80) and between stroke and suicidal ideation (odds ratio = 1.37; 95% confidence interval = 1.10, 1.69). Caucasians and younger individuals had higher odds of poststroke depression and suicidal ideation. Stroke survivors with functional limitations had much higher odds of suicidal ideation than those without such limitations. Conclusions Regular screening for depression and suicidal ideation is important for stroke survivors, particularly those with substantial physical limitations.
Effect of Flax Addition on the Flavor Profile and Acceptability of Bagels
Authors: Aliani Michel , Ryland Donna , Pierce Grant N. 
Published: January 2012

Abstract:  Bakery products containing flaxseed, a rich source of alpha linolenic acid (ALA), may provide health benefits. However, the effect of adding flaxseed, especially in the high amounts required for use as the food supplement in clinical trials (23% by weight of the raw ingredients), may affect the flavor characteristics and consumer acceptability. Sensory attributes of bagels containing 30 g of milled flaxseed were evaluated by a 9 member trained panel using a descriptive test and by 89 participants using a consumer test. Grain/flax aroma and flavor were significantly higher for the flax bagels compared to the nonflax bagels. The cinnamon raisin bagel had significantly lower grain/flax aroma and flavor and significantly higher sweet aroma and taste compared to the plain and sunflower sesame types. Older consumers rated the appearance, color, and flavor of the bagels significantly higher than the younger consumers possibly leading to higher compliance in clinical studies for this age group. Bagels with flax showed a significantly lower mean value for flavor acceptability, overall acceptability, and frequency of eating compared to bagels without flax. Appearance, color, and texture acceptability showed no significant differences. The cinnamon raisin bagel had significantly higher flavor acceptance compared to sunflower sesame and plain bagels. In conclusion, for bagels containing 6 g ALA in the form of milled flaxseed, cinnamon raisin appears to be a promising flavoring alternative for ALA fortification for use in clinical trials or as part of the daily diet.Practical Application:  Consumers are seeking functional foods that contain omega‐3 fatty acids. Bagels made with 23% milled flaxseed (approximately 2 times the amount in regular flax baked products) provided 6 g ALA, an amount high enough to test the efficacy of ALA in human subjects without causing gastrointestinal distress. This study showed that flaxseed aroma and flavor were detected in fortified compared to nonfortified bagels but bagels with this high flaxseed amount were still acceptable with the addition of cinnamon raisin flavoring. Commercial bakeries can use these results to formulate healthy, tasty, and convenient products.
Functional expression of voltage‐gated calcium channels in human melanoma
Authors: Das A. , Pushparaj C. , Bahí N. , Sorolla A. , Herreros J. , Pamplona R. , Vilella R. , Matias‐Guiu X. , Martí R. M. , Cantí C. 
Published: January 2012

SummaryThe expression of voltage‐gated calcium channels (VGCCs) has not been reported previously in melanoma cells in spite of increasing evidence of a role of VGCCs in tumorigenesis and tumour progression. To address this issue we have performed an extensive RT‐PCR analysis of VGCC expression in human melanocytes and a range of melanoma cell lines and biopsies. In addition, we have tested the functional expression of these channels using Ca2+ imaging techniques and examined their relevance for the viability and proliferation of the melanoma cells. Our results show that control melanocytes and melanoma cells express channel isoforms belonging to the Cav1 and Cav2 gene families. Importantly, the expression of low voltage‐activated Cav3 (T‐type) channels is restricted to melanoma. We have confirmed the function of T‐type channels as mediators of constitutive Ca2+ influx in melanoma cells. Finally, pharmacological and gene silencing approaches demonstrate a role for T‐type channels in melanoma viability and proliferation. These results encourage the analysis of T‐type VGCCs as targets for therapeutic intervention in melanoma tumorigenesis and/or tumour progression.
Key Issues in Foreign Language Writing
Authors: Reichelt Melinda , Lefkowitz Natalie , Rinnert Carol , Schultz Jean Marie 
Published: January 2012

AbstractIn this article, four second language writing specialists address the following significant questions related to foreign language (FL) writing instruction: (1) How is FL writing different from English as a second language writing? (2) How does the sociolin‐guistic role of a given FL influence how writing is employed in the overall curriculum for that FL? (3) What role should writing play in the FL classroom? (4) What are possible purposes for students writing in FLs, especially in contexts where students’ real‐life needs for FL writing are not immediately obvious? Drawing on their varying backgrounds, the authors provide insights into these issues and pose directions for future research.
Elucidating Prognosis and Biology of Breast Cancer Arising in Young Women Using Gene Expression Profiling
Authors: Azim Hatem A. , Michiels Stefan , Bedard Philippe L. , Singhal Sandeep K. , Criscitiello Carmen , Ignatiadis Michail , Haibe-Kains Benjamin , Piccart Martine J. , Sotiriou Christos , Loi Sherene 
Published: January 2012

AbstractPurpose: Breast cancer in young women is associated with poor prognosis. We aimed to define the role of gene expression signatures in predicting prognosis in young women and to understand biological differences according to age.Experimental Design: Patients were assigned to molecular subtypes [estrogen receptor (ER)+/HER2−; HER2+, ER−/HER2−)] using a three-gene classifier. We evaluated whether previously published proliferation, stroma, and immune-related gene signatures added prognostic information to Adjuvant! online and tested their interaction with age in a Cox model for relapse-free survival (RFS). Furthermore, we evaluated the association between candidate age-related genes or gene sets with age in an adjusted linear regression model.Results: A total of 3,522 patients (20 data sets) were eligible. Patients aged 40 years or less had a higher proportion of ER−/HER2− tumors (P &lt; 0.0001) and were associated with poorer RFS after adjustment for breast cancer subtype, tumor size, nodal status, and histologic grade and stratification for data set and treatment modality (HR = 1.34, 95% CI = 1.10–1.63, P = 0.004). The proliferation gene signatures showed no significant interaction with age in ER+/HER2− tumors after adjustment for Adjuvant! online. Further analyses suggested that breast cancer in the young is enriched with processes related to immature mammary epithelial cells (luminal progenitors, mammary stem, c-kit, RANKL) and growth factor signaling in two independent cohorts (n = 1,188 and 2,334).Conclusions: Proliferation-related prognostic gene signatures can aid treatment decision-making for young women. However, breast cancer arising at a young age seems to be biologically distinct beyond subtype distribution. Separate therapeutic approaches such as targeting RANKL or mammary stem cells could therefore be needed. Clin Cancer Res; 18(5); 1341–51. ©2012 AACR.
Human Prostate Cancer in a Clinically Relevant Xenograft Mouse Model: Identification of β(1,6)-Branched Oligosaccharides as a Marker of Tumor Progression
Authors: Lange Tobias , Ullrich Sebastian , Müller Imke , Nentwich Michael F. , Stübke Katrin , Feldhaus Susanne , Knies Christine , Hellwinkel Olaf J.C. , Vessella Robert L. , Abramjuk Claudia , Anders Mario , Schröder-Schwarz Jennifer , Schlomm Thorsten , Huland Hartwig , Sauter Guido , Schumacher Udo 
Published: January 2012

Abstract
Purpose: To establish xenograft mouse models of metastatic and nonmetastatic human prostate cancer and to apply these models to the search for aberrant glycosylation patterns associated with tumor progression in vivo and in patients.
Experimental Design: Prostate cancer cells (LNCaP, PC-3, LuCaP 23.1, and DU-145) were xenografted subcutaneously into immunodeficient pfp−/−/rag2−/− mice. Tumor growth and metastasis formation were quantified and as altered glycosylation patterns have been associated with metastasis formation in several other malignancies, prostate cancer cells were profiled by a quantitative real-time PCR (qRT-PCR) glycosylation array and compared with normal human prostate cells. The activity of upregulated glycosyltransferases was analyzed by their sugar residues end products using lectin histochemistry on primary tumors and metastases in the animal experiments and on 2,085 clinical samples.
Results: PC-3 cells produced the largest number of spontaneous lung metastases, followed by LNCaP and LuCaP 23.1, whereas DU-145 was nonmetastatic. qRT-PCR revealed an upregulation of β1,6-N-acetylglucosaminyltransferase-5b (Mgat5b) in all prostate cancer cell lines. Mgat5b products [β(1,6)-branched oligosaccharides] were predominantly detectable in metastatic xenografts as shown by increased binding of Phaseolus vulgaris leukoagglutinin (PHA-L). The percentage of prostate cancer patients who were PHA-L positive was 86.5. PHA-L intensity correlated with serum prostate-specific antigen and a cytoplasmic staining negatively affected disease-free survival.
Conclusion: We show a novel xenograft mouse model for human prostate cancer respecting the complete metastatic cascade. Specific glycosylation patterns reveal Mgat5b products as relevant markers of both metastatic competence in mice and disease-free survival in patients. This is the first description of Mgat5b in prostate cancer indicating a significant biologic importance of β(1,6)-branched oligosaccharides for prostate cancer progression. Clin Cancer Res; 18(5); 1364–73. ©2012 AACR.