bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strain engineering of electronic, mechanical, and optical properties of orthorhombic III–V group monolayers by first principles calculations
Authors: Jin Xuehu , Yao Can , Qi Yunxi , Zhao Jun , Zeng Hui 
Published: May 2024

Using first principles calculations, we systematically investigated the effects of strain engineering on the electronic, mechanical, and optical properties of two-dimensional (2D) orthorhombic III–V group materials, including BN, BP, BAs, AlN, AlP, and GaN. It is shown that all the III–V orthorhombic monolayers exhibit excellent mechanical anisotropy for Young’s modulus, Shear modulus, and Poisson’s ratio, especially for the AlN and GaN monolayers. AlN, AlP, and GaN are predicted to be indirect bandgap semiconductors, with their bandgap of 0.70, 0.15, and 0.53 eV, respectively. And BN is demonstrated to be a direct bandgap semiconductor (0.63 eV). Under uniaxial tensile strains, their electronic structures have non-monotonic anisotropic variations and these monolayers can be effectively modulated from metal to semiconductor, experiencing indirect–direct bandgap transitions. In addition, all the orthorhombic III–V materials exhibit highly anisotropic light-harvesting performances and the optical absorbance can be efficiently tailored with tensile strains applied along a- and b-directions. The strong optical absorptions in the visible light regions suggested that AlN, BN, and GaN may be optically tunable 2D materials for component absorbance layers for solar cell applications. The excellent anisotropic and tunable electronic, mechanical, and optical performances indicate that the orthorhombic III–V monolayers are promising candidates for potential applications of optoelectronics and photovoltaics.
Early On-Treatment Assessment of T Cells, Cytokines, and Tumor DNA with Adaptively Dosed Nivolumab + Ipilimumab: Final Results from the Phase 2 ADAPT-IT Study
Authors: Smithy James W. , Kalvin Hannah L. , Ehrich Fiona D. , Shah Ronak , Adamow Matthew , Raber Vladislav , Maher Collen A. , Kleman Jenna , McIntyre Deborah A.G. , Shoushtari Alexander N. , Betof Warner Allison , Callahan Margaret K. , Momtaz Parisa , Eton Omar , Nair Suresh , Wolchok Jedd D. , Chapman Paul B. , Berger Michael F. , Panageas Katherine S. , Postow Michael A. 
Published: May 2024

Abstract

Purpose:
The Adaptively Dosed ImmunoTherapy Trial (ADAPT-IT;NCT03122522) investigated adaptive ipilimumab discontinuation in melanoma based on early radiographic assessment. Initial findings indicated similar effectiveness compared with conventional nivolumab-ipilimumab (nivo-ipi). Exploratory biomarker analyses and final clinical results are now reported.

Patients and Methods:
Patients with unresectable melanoma received two doses of nivo-ipi. Radiographic assessment at Week 6 informed continuation of ipilimumab before nivolumab maintenance. The primary endpoint was overall response rate at Week 12. Plasma was assayed for circulating tumor DNA and 10 cytokines using a multiplex immunoassay. Flow cytometry of peripheral blood mononuclear cells was performed with an 11-color panel.

Results:
Among the treated patients, expansion of proliferating T-cell populations was observed in responders and nonresponders. Baseline IL6 levels were low in patients achieving an objective radiographic response (median 1.30 vs. 2.86 pg/mL; P = 0.025). High baseline IL6 levels were associated with short progression-free survival [PFS; HR = 1.24, 95% confidence interval (CI), 1.01–1.52; P = 0.041]. At Week 6, patients with response had lower average tumor variant allele fractions than nonresponders (median 0.000 vs. 0.019; P = 0.014). Greater increases in average variant allele fractions from baseline to Week 6 correlated with short PFS (HR = 1.11, 95% CI, 1.01–1.21; P = 0.023). Week 12 overall response rate was 47% (95% CI, 35%–59%) with a median follow-up of 34 months among survivors. Median PFS was 21 months (95% CI, 10–not reached); 76% of responses (95% CI, 64%–91%) persisted at 36 months.

Conclusions:
Adaptively dosed nivo-ipi responses are durable and resemble historical data for conventional nivo-ipi. Baseline IL6 and circulating tumor DNA changes during treatment warrant further study as biomarkers of nivo-ipi response.
Improvement of Tumor Neoantigen Detection by High-Field Asymmetric Waveform Ion Mobility Mass Spectrometry
Authors: Meng Wei , Takeuchi Yoshiko , Ward Jeffrey P. , Sultan Hussein , Arthur Cora D. , Mardis Elaine R. , Artyomov Maxim N. , Lichti Cheryl F. , Schreiber Robert D. 
Published: May 2024

Abstract
Cancer neoantigens have been shown to elicit cancer-specific T-cell responses and have garnered much attention for their roles in both spontaneous and therapeutically induced antitumor responses. Mass spectrometry (MS) profiling of tumor immunopeptidomes has been used, in part, to identify MHC-bound mutant neoantigen ligands. However, under standard conditions, MS-based detection of such rare but clinically relevant neoantigens is relatively insensitive, requiring 300 million cells or more. Here, to quantitatively define the minimum detectable amounts of therapeutically relevant MHC-I and MHC-II neoantigen peptides, we analyzed different dilutions of immunopeptidomes isolated from the well-characterized T3 mouse methylcholanthrene (MCA)-induced cell line by MS. Using either data-dependent acquisition or parallel reaction monitoring (PRM), we established the minimum amount of material required to detect the major T3 neoantigens in the presence or absence of high field asymmetric waveform ion mobility spectrometry (FAIMS). This analysis yielded a 14-fold enhancement of sensitivity in detecting the major T3 MHC-I neoantigen (mLama4) with FAIMS-PRM compared with PRM without FAIMS, allowing ex vivo detection of this neoantigen from an individual 100 mg T3 tumor. These findings were then extended to two other independent MCA-sarcoma lines (1956 and F244). This study demonstrates that FAIMS substantially increases the sensitivity of MS-based characterization of validated neoantigens from tumors.
Lifestyle modifications among older adults with prehypertension in primary care
Authors: Boonsaad Potsunee , Chompoopan Worawut 
Published: May 2024

In both global and Thai contexts, unhealthy behaviors such as alcohol consumption, smoking, excessive salt intake, and sedentary lifestyles contribute to hypertension. World Health Organization (WHO) recommends lifestyle adjustments for blood pressure control. This quasi-experimental study examined the impact of an intervention on elderly individuals with prehypertension. People living in two villages were selected, matching two others demographically and geographically. The intervention focused on a balanced diet, physical activity, stress management, and reduced tobacco/alcohol use with a low-sodium diet. Blood pressure and heart rate were measured three times after a 10-minute rest using a calibrated sphygmomanometer. The study showed significant improvements with p&lt;0.001. Systolic blood pressure decreased by 5.94 mmHg, diastolic blood pressure decreased by 3.37 mmHg, and heart rate decreased by 4.12 bpm. The findings emphasize the importance of comprehensive lifestyle modifications to manage prehypertension and reduce hypertension-related complications in older people. Further research and interventions are needed to address people with hypertension globally, including in Thailand.
Factors predicting on health behaviors among older adults with hypertension in community
Authors: Pholputta Ladda , Toemjai Thawatchai , Phenphol Nitchapanrawee , Sayuen Chanidawadee , Udobsat Sattawas , Wongpimoln Boonyada 
Published: May 2024

In Thailand the prevalence of hypertension continues to rise and health behavior of older adults is generally suboptimal. The purpose of this study was to identify the characteristics that can identify health behavior in older persons with hypertension. A cross-sectional design study was carried out on 123 hypertensive older persons in Koh Kaew Sub-District, Sela Phum District, Roi Et Province, who were chosen using a simple random selection procedure. In-person interviews with structured questionnaires were used for gathering data. This study utilized surveys to collect demographic information, health beliefs, and health habits. Percentage, mean, standard deviation, and stepwise multiple regression were used to evaluate the data. The results showed that there were four factors together predict and explain the variance of health behaviors among older adults with hypertension accounting R<sup>2</sup> and adjusted R<sup>2</sup> value were 44.10% and 42.20% with statistical significance including female (β=0.242, p=0.001), perceived susceptibility (β=0.419, p&lt;0.001), perceived barriers (β=0.239, p=0.001), and perceived benefits (β=0.181, p=0.013). To improve quality of life among older persons with hypertension, this research proposed involving healthcare providers, families, and health volunteers in promoting their health habits.
Groundwater and indoor air quality of urban village housing: study in Janturan, Warungboto, Yogyakarta
Authors: Mahfudh Nurkhasanah , Prasasti Dian , Ananda Anugrah Tri , Rahmawati Frida , Sulistyawati Sulistyawati , Muchlis Muchlis , Murtyas Solli Dwi , Hagishima Aya 
Published: May 2024

Water and air are important elements for life. The presence of pathogenic bacteria in the surrounding environment can cause health problems resulting from the low quality of water and air. The purpose of this study is to measure the quality of groundwater and air based on microbiological parameters in urban village housing. This research was conducted in a descriptive survey, and a purposive sampling technique was carried out. Groundwater and air samples were taken from six residents' houses located in the Janturan area. The water quality test used the most probable number (MPN) method and the air quality test used the agar filter method using a microbiological air sampler (MAS) to trap microbes. The results of the MPN test for total coliform bacteria from six samples of groundwater showed that three samples were positive for coliform bacteria which exceeded the threshold according to Indonesian standard&lt;50 MPN/100 ml. Assay of <em>E. coli</em> bacteria showed that all samples of groundwater positively contained <em>E. coli</em> bacteria which exceeded the threshold of 0 MPN/100 ml. The results of indoor air quality measurements from 6 residents' houses showed that five houses have air quality did not meet the standard for indoor air germ numbers based on Indonesian standard, less than 700 CFU/m3 (colony forming units per metres cubic) and 1 house that got the number of airborne germs, in the normal range, namely 356 CFU/m3. It was concluded that the water quality and air quality in the urban village did not meet health requirements.
Improving the Modeled Variability Estimates of Offshore Winds in Northern Europe by Nudging ASCAT-Derived Winds
Authors: Alonso-De-Linaje Nicolas G. , Hahmann Andrea N. , Karagali Ioanna , Dimitriadou Krystallia , Badger Merete 
Published: May 2024

Abstract
The paper aims to demonstrate how to enhance the accuracy of offshore wind resource estimation, specifically by incorporating near-surface satellite-derived wind observations into mesoscale models. We utilized the Weather Research and Forecasting (WRF) Model and applied observational nudging by integrating ASCAT data over offshore areas to achieve this. We then evaluated the accuracy of the nudged WRF Model simulations by comparing them with data from ocean oil platforms, tall masts, and a wind lidar mounted on a commercial ferry crossing the southern Baltic Sea. Our findings indicate that including satellite-derived ASCAT wind speeds through nudging enhances the correlation and reduces the error of the mesoscale simulations across all validation platforms. Moreover, it consistently outperforms the control and previously published WRF-based wind atlases. Using satellite-derived winds directly in the model simulations also solves the issue of lifting near-surface winds to wind turbine heights, which has been challenging in estimating wind resources at such heights. The comparison of the 1-yr-long simulations with and without nudging reveals intriguing differences in the sign and magnitude between the Baltic and North Seas, which vary seasonally. The pattern highlights a distinct regional pattern attributed to regional dynamics, sea surface temperature, atmospheric stability, and the number of available ASCAT samples.

Significance Statement
We aim to showcase a method for improving the precision of hub-height estimation of wind resources offshore. This involves integrating wind observations obtained from near-surface satellites into the model simulations. To assess the accuracy of the simulations, we compare the simulated winds to data gathered from multiple offshore sources, including oil platforms, tall masts, and a wind lidar installed on a commercial ferry.
Estimating Wind Speeds in Tornadoes Using Debris Trajectories of Large Compact Objects
Authors: Miller Connell S. , Kopp Gregory A. , Sills David M. L. , Butt Daniel G. 
Published: May 2024

Abstract
Currently, the enhanced Fujita scale does not consider the wind-induced movement of various large compact objects such as vehicles, construction equipment, and farming equipment/haybales that are often found in postevent damage surveys. One reason for this is that modeling debris in tornadoes comes with considerable uncertainties since there are many parameters to determine, leading to difficulties in using trajectories to analyze wind speeds of tornadoes. This paper aims to develop a forensic tool using analytical tornado models to estimate lofting wind speeds based on trajectories of large compact objects. This is accomplished by implementing a Monte Carlo simulation to randomly select the parameters and plotting cumulative distribution functions showing the likelihood of lofting at each wind speed. After analyzing the debris lofting from several documented tornadoes in Canada, the results indicate that the method provides threshold lofting wind speeds that are similar to the estimated speeds given by other methods. However, the introduction of trajectories produces estimated lofting wind speeds that are higher than the EF-scale rating given from the ground survey assessment based on structural damage. Further studies will be required to better understand these differences.
Rumination and Forgiveness in Emerging Adults: Mediating Role of Mindfulness and Humility
Authors: Uzun Kıvanç , Arslan Gökmen 
Published: May 2024

The objective of this study was to examine whether mindfulness and humility mediate the influence of rumination on forgiveness among emerging adults. The sample consisted of 392 individuals in the emerging adulthood stage, residing in Türkiye, with 69.10% females and 30.90% males, aged between 18 and 25 years ( M = 20.19, SD = 1.77). Data were collected through a demographic information form and four self-report scales. In addition to descriptive statistics, Pearson’s correlation coefficient and bootstrap analysis were employed for data analysis. According to the study’s findings, it can be inferred that ruminative thoughts among emerging adults hinder their ability to forgive. Furthermore, the study revealed that mindfulness and humility serve as mediators in the relationship between ruminative thoughts and forgiveness in emerging adults. In this context, it can be concluded that leveraging the positive effects of mindfulness and humility can mitigate the adverse impact of rumination on forgiveness among emerging adults, thus enhancing their inclination towards forgiveness.
Prevalence and risk factors for chronic kidney disease among older adult patients with schizophrenia in Taiwan
Authors: Chang Shu-Ting , Liou Jiunn-Ying , Wu Bo-Jian , Chen Hsing-Kang 
Published: May 2024

Objectives There is an increasing incidence and prevalence of patients with chronic kidney disease (CKD) worldwide. Little is known the prevalence of CKD among older patients with schizophrenia. The purpose of this study was to investigate the prevalence of CKD and its risk factors in older adults with schizophrenia. Methods In this cross-sectional study, a convenience sample of 240 patients with schizophrenia age 50 or older was recruited. In addition to demographic and clinical data, participants’ estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease equation based on age, sex, ethnicity, and serum creatinine level determined from a blood sample taken from participants. Results The overall prevalence of CKD was 11.3%. Those with CKD were older, had a longer duration of psychiatric illness, a higher body mass index (BMI), and diagnoses of hypertension compared to those in the non-CKD group. Independent of other risk factors, older age and BMI were significantly associated with CKD. Conclusions This study found that the overall prevalence of CKD in older patients with schizophrenia was 11.3%. Independent risk factors for CKD in this population were older age and higher BMI. In addition to early identification and early treatment of CKD in older patients with schizophrenia, clinicians should actively manage the risk factors identified in this study.
Can a low prime volume arterial filter be used as an alternative for a venous bubble trap in minimal extracorporeal circulation? An in vitro investigation
Authors: Stehouwer Marco , Legg Kristina , Vroege Roel de 
Published: May 2024

Background During cardiac surgery the use of a minimal extracorporeal circulation (MiECC) system may reduce the adverse effects for the patient. This is probably caused by reduced inflammation and hemodilution. For the use of a MiECC circuit, a venous bubble trap (VBT) is warranted for safety reasons. The aim of this study was to assess if an arterial filter with a small prime volume has the same (or better) air removal capacities as a VBT in a MiECC circuit and subsequentially may be used as an alternative. Methods In an in vitro study, air removal properties were compared between the arterial filter and three VBT’s on the market, VBT160 (Getinge), VBT 8 (LivaNova and VARD (Medtronic). In a MiECC circuit, the filter devices were placed in a venous position and challenged with massive and micro air. Gaseous microemboli (GME) were measured with a bubble counter proximal and distal of the VBT device. Results More than 99.9 % of the air was removed after a bolus air challenge by all VBT’s. Both the VARD and the AF100 showed better GME removal properties (not significant for the AF100) compared to the other devices. All filters showed GME generation after a challenge with massive air. Compared to the other filters, only the VARD showed no passing of larger bubbles when a volume of 50 mL of air was present in the filter. Conclusions The AF100 seems to be a safe and low prime alternative for use in a MiECC system as a venous air trap. A word of caution, placement of the AF100 arterial filter in the venous line is off label use.
Efficacy and safety of antegrade sclerotherapy for varicocele in pediatric patients: A systematic review
Authors: Aiello Giuseppe , Morlacco Alessandro , Motterle Giovanni , Bianco Marta , Mancini Mariangela , Beltrami Paolo , Zattoni Fabio , Iafrate Massimo , dal Moro Fabrizio 
Published: May 2024

Objectives: Antegrade sclerotherapy (Tauber’s) procedure has been extensively used for the minimally-invasive treatment of varicocele; however, the results in the pediatric population are less defined. This systematic review evaluates the efficacy and safety of antegrade sclerotherapy for varicocele in the pediatric population. Evidence acquisition: The review was conducted following the PRISMA guidelines. Systematic research of available literature in English language from 1980 until May 2022 was conducted through EMBASE, MEDLINE, Cochrane Library, and NIH Registry of Clinical Trials. For each study, information was gathered regarding the study design, the inclusion/exclusion criteria, the indications for treatment, the success rate and the complications. When available, the details about sperm analysis were reported. Evidence synthesis: The 10 studies were included in the final sample (564 patients). Median age of patients ranged 13.3–15.3 years. The indications for scleroembolization varied in the different studies, while most studies included patients with clinical G2-G3 varicocele and clinical symptoms or testicular asymmetry. The treatment was successful in 88%–98% of the patients, while the complication rate was <5%. Conclusion: Tauber’s sclerotherapy is a safe and effective treatment for varicocele also in the pediatric population. Further studies with standardized inclusion criteria are needed to provide higher level of evidence and compare the outcomes of antegrade sclerotherapy with the other available techniques.
Health-related quality of life after total knee arthroplasty and unicompartmental knee arthroplasty for unicompartmental osteoarthritis: A systematic review and meta-analysis
Authors: Song Ke , Qi Liping , Mu Zongyou , Sun Houyi , Zhai Shenhao , Liu Dehua , Li Shihao , Luo Yange , Liu Peilai 
Published: May 2024

Background While previous research has demonstrated potential advantages of unicompartmental knee arthroplasty (UKA) over total knee arthroplasty (TKA), particularly in terms of clinical outcomes such as function and pain relief, the specific impact on health-related quality of life (HRQOL) remains unclear. This systematic review and meta-analysis aim to address this gap by comparing HRQOL outcomes between UKA and TKA, providing valuable insights for clinical decision-making. Methods We conducted a literature search in the PubMed, Embase, Cochrane Controlled Register of Trials (CENTRAL), and Web of Science databases up to July 15, 2023. Eligible studies assessed HRQOL using EQ-5D, SF-36, or SF-12 and were assessed for methodological quality using the Newcastle-Ottawa Scale (NOS). Results Seven eligible studies were included, comprising a total of 64,585 patients with 35,809 undergoing TKA and 28,776 undergoing UKA. Patient age ranged from 52.0 to 67.7 years with an average BMI ranging from 27.2 to 31.0 kg/m2. Follow-up periods ranged from 6 months to 10 years. Five studies (63,829 patients) that evaluated HRQOL using EQ-5D showed significantly better outcomes for UKA compared to TKA (MD -0.04, 95% CI -0.05 to −0.02). Two studies (756 patients) that evaluated HRQOL using SF-36 showed no significant difference between TKA and UKA. Five studies (63,286 patients) that evaluated functional outcomes using Oxford Knee Score (OKS) showed significantly better functional scores for UKA compared to TKA (MD -1.29, 95% CI -1.86 to −0.72). Four studies (24,570 patients) that reported patient satisfaction showed no statistically significant difference between TKA and UKA (MD 0.97, 95% CI 0.90 to 1.05). Further subgroup analysis did not affect the conclusions. Conclusions Our meta-analysis suggests that UKA is associated with better HRQOL and knee function, as well as similar patient satisfaction, compared to TKA for patients with unicompartmental osteoarthritis.