bluuebunny/crossref_metadata_2025_split huggingface dataset:
Controlled Regulation of N‐Involved TiO2 Nanoflowers in Size and Morphology via Solvothermal Synthesis for Enhanced Photocatalytic Performance
Authors: Wang Zhihui , Han Yandong , Xu Yongde , Guo Zilong , Han Mingyong , Yang Wenshang 
Published: June 2024

AbstractThe precise control of size and morphology of photocatalysts through solvothermal methods is a challenge in the basic research of 3‐D titanium dioxide (TiO2) hierarchical structures. This study utilizes the solvothermal method to synthesize N‐involved TiO2 nanoflowers with nanosheet‐assembled structures ranging from microscale (1.3 µm ± 0.2 µm) to nanoscale (200 nm ± 50 nm), achieved by varying the volume fraction (percentage by volume, vol%) of N‐N‐dimethylformamide (DMF) from 0% to 75% in a mixed solution of DMF and isopropanol (IPA). The synthesized TiO2:VFDMF = 0–75% catalyst exhibits good monodispersity and uniform particle size. With increasing DMF volume percentage, the size of TiO2:VFDMF = 0–75% decreased regularly, and the number of nanosheets constructed with a single TiO2:VFDMF = 0–75% particle decreased without any stacking or reassembly occurring. This study monitors the solvothermal processes of DMF 5% and DMF 75%, revealing the changing rules of nanoparticle size and morphology. Furthermore, the photocatalytic degradation of methyl orange shows that TiO2:VFDMF = 50% and TiO2:VFDMF = 75% are structurally stable and exhibit good photocatalytic activity without any noble metal doping. The degradation efficiency reaches 99.9%, and after repeated use, the catalysts demonstrate excellent degradation performance.
Symmetrical Design of Biphenazine Derivative Anode for Proton Ion Batteries with High Voltage and Long‐Term Cycle Stability
Authors: Wang Caixing , He Dunyong , Wang Huaizhu , Guo Jiandong , Bao Zhuoheng , Feng Yuge , Hu Linfeng , Zheng Chenxi , Zhao Mengfan , Wang Xuemei , Wang Yanrong 
Published: June 2024

AbstractOrganic anodes have emerged as a promising energy storage medium in proton ion batteries (PrIBs) due to their ability to reversibly accommodate non‐metallic proton ions. Nevertheless, the currently available organic electrodes often encounter dissolution issues, leading to a decrease in long‐cycle stability. In addition, the inherent potential of the organic anode is generally relatively high, resulting in low cell voltage of assembled PrIBs (<1.0 V). To address these challenges, a novel long‐period stable, low redox potential biphenylzine derivative, [2,2′‐biphenazine]‐7,7′‐tetraol (BPZT) is explored, from the perspective of molecular symmetry and solubility, in conjunction with the effect of the molecular frontier orbital energy levels on its redox potential. Specifically, BPZT exhibited a low potential of 0.29 V (vs SHE) and is virtually insoluble in 2 m H2SO4 electrolyte during cycling. When paired with MnO2@GF or PbO2 cathodes, the resulting PrIBs achieve cell voltages of 1.07 V or 1.44 V, respectively, and maintain a high capacity retention of 90% over 20000 cycles. Additionally, these full batteries can operate stably at a high mass loading of 10 mgBPZT cm−2, highlighting their potential toward long‐term energy storage applications.
Guideline for the cognitive assessment and follow‐up in the Guangdong‐Hong Kong‐Macao Greater Bay Area (2024 edition)
Authors: Peng Jialing , Mai Yingreng , Liu Jun 
Published: June 2024

AbstractThis practice guideline focuses on the cognitive assessment for mild cognitive impairment in the Guangdong‐Hong Kong‐Macao Greater Bay Area. To achieve the standardization and normalization of its clinical practice and generate individualized intervention, the National Core Cognitive Center of the Second Affiliated Hospital of Guangzhou Medical University, the Cognitive Disorders Branch of Chinese Geriatic Society, the Dementia Group of Neurology Branch of Guangdong Medical Association and specialists from Hong Kong and Macao developed guidelines based on China's actual conditions and efficiency, economic cost and accuracy. The article addresses the significance, background, and the process of the assessment and follow‐up to realize the promotion and dissemination of cognitive assessment.
Exploratory bibliometric analysis and text mining to reveal research trends in cardiac aging
Authors: Kamihara Takahiro , Tanaka Ken , Omura Takuya , Kaneko Shinji , Hirashiki Akihiro , Kokubo Manabu , Shimizu Atsuya 
Published: June 2024

AbstractObjectivesWe conducted a text mining analysis of 40 years of literature on cardiac aging from PubMed to investigate the current understanding on cardiac aging and its mechanisms. This study aimed to embody what most researchers consider cardiac aging to be.MethodsWe used multiple text mining and machine learning tools to extract important information from a large amount of text.ResultsAnalysis revealed that the terms most frequently associated with cardiac aging include “diastolic,” “hypertrophy,” “fibrosis,” “apoptosis,” “mitochondrial,” “oxidative,” and “autophagy.” These terms suggest that cardiac aging is characterized by mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. We also revealed an increase in the frequency of occurrence of “autophagy” in recent years, suggesting that research on autophagy has made a breakthrough in the field of cardiac aging. Additionally, the frequency of occurrence of “mitophagy” has increased significantly since 2019, suggesting that mitophagy is an important factor in cardiac aging.ConclusionsCardiac aging is a complex process that involves mitochondrial dysfunction, oxidative stress, and impairment of autophagy, especially mitophagy. Further research is warranted to elucidate the mechanisms of cardiac aging and develop strategies to mitigate its detrimental effects.
Association between advanced lung cancer inflammation index and in‐hospital mortality in ICU patients with community‐acquired pneumonia: A retrospective analysis of the MIMIC‐IV database
Authors: Yang Feng , Gao Lianjun , Xu Cuiping , Wang Qimin , Gao Wei 
Published: June 2024

AbstractObjectiveThe objective of the present study was to explore the correlation between the advanced lung cancer inflammation index (ALI) and in‐hospital mortality among patients diagnosed with community‐acquired pneumonia (CAP).MethodsData from the Medical Information Mart for Intensive Care‐IV database were adopted to analyze the in‐hospital mortality of ICU patients with CAP. Upon admission to the ICU, fundamental data including vital signs, critical illness scores, comorbidities, and laboratory results, were collected. The in‐hospital mortality of all CAP patients was documented. Multivariate logistic regression (MLR) models and restricted cubic spline (RCS) analysis together with subgroup analyses were conducted.ResultsThis study includes 311 CAP individuals, involving 218 survivors as well as 93 nonsurvivors. The participants had an average age of 63.57 years, and the females accounted for approximately 45.33%. The in‐hospital mortality was documented to be 29.90%. MLR analysis found that ALI was identified as an independent predictor for in‐hospital mortality among patients with CAP solely in the Q1 group with ALI ≤ 39.38 (HR: 2.227, 95% CI: 1.026–4.831, P = 0.043). RCS analysis showed a nonlinear relationship between the ALI and in‐hospital mortality, with a turning point at 81, and on the left side of the inflection point, a negative correlation was observed between ALI and in‐hospital mortality (HR: 0.984, 95% CI: 0.975–0.994, P = 0.002). The subgroup with high blood pressure showed significant interaction with the ALI.ConclusionThe present study demonstrated a nonlinear correlation of the ALI with in‐hospital mortality among individuals with CAP. Additional confirmation of these findings requires conducting larger prospective investigations.
Gut microbiota in centenarians: A potential metabolic and aging regulator in the study of extreme longevity
Authors: Lozada‐Martinez Ivan David , Lozada‐Martinez Luz Miryam , Anaya Juan‐Manuel 
Published: June 2024

AbstractCentenarians, those aged 100 years or older, are considered the most successful biological aging model in humans. This population is commonly characterized by a low prevalence of chronic diseases, with favorable maintenance of functionality and independence, thus determining a health phenotype of successful aging. There are many factors usually associated with extreme longevity: genetics, lifestyles, diet, among others. However, it is most likely a multifactorial condition where protective factors contribute individually to some extent. The gut microbiota (GM) has emerged as a potential factor associated with the establishment of a favorable health phenotype that allows for extreme longevity, as seen in centenarians. To understand the possible impact generated by the GM, its changes, and the probable causes for successful aging, the aim of this review was to synthesize evidence on the role of the GM as a potential protective factor for achieving extreme longevity, using its relationship with centenarians.
A clusteroluminescent supramolecular polymer network constructed by pillararene and its application in information encryption
Authors: Zhang Meiru , Cheng Yujie , Zhang Ting , Liang Bicong , Wei Xuehong , Wang Pi , Xia Danyu , Yan Xuzhou 
Published: June 2024

AbstractClusterization‐triggered emissive (CTE) materials have attracted great attention in recent years. The regulation of the emission property of materials with CTE property through supramolecular interactions is an excellent strategy for the construction of smart fluorescent materials. In this work, we have prepared a regulatable supramolecular polymer network with CTE properties through pillararene‐based host−guest interactions. The pillar[5]arene‐grafted poly(methyl methacrylate) (PMMA) showed a classic CTE character. After adding Brooker's merocyanine‐grafted polymer to the solution of the pillar[5]arene‐containing PMMA, the supramolecular polymer network gel formed by the host−guest interactions between pillararene and Brooker's merocyanine guest. This supramolecular network showed brighter fluorescence than the pillar[5]arene‐grafted PMMA in the solid state. In addition, the fluorescence emission of the supramolecular network can be further regulated by pH conditions. After adding an acid, the Brooker's merocyanine‐containing guest polymer was protonated, and the supramolecular network changed to a protonated network through host−guest interactions between protonated Brooker's merocyanine guest and pillararene. Interestingly, the fluorescence was quenched when the supramolecular network turned into the protonated network. After adding a base, the protonated network can convert back to the original network, along with recovery of the fluorescence. Therefore, the regulation of the fluorescence of the supramolecular polymer materials with CTE was successfully realized by pillararene‐based host−guest interactions. Furthermore, this tailorable fluorescent supramolecular polymer network system was applied as an information encryption material.
Expanding the phenotype of Harel‐Yoon syndrome: A case report suggesting a genotype/phenotype correlation
Authors: Abdul‐Raheem Jareatha , Nikkola Elina , Chen Zhenbin , Rohena Luis 
Published: June 2024

AbstractHarel‐Yoon syndrome (HAYOS) is a unique neurodevelopmental genetic disorder characterized by hypotonia, spasticity, intellectual disability, hypertrophic cardiomyopathy, and global developmental delay. It primarily results from mutations in the ATAD3A gene, pivotal for mitochondrial function. This report presents a 5‐year‐old girl with HAYOS harboring a de novo heterozygous variant c.1064G>A; (p.G355D) in ATAD3A. Her clinical profile includes delayed milestones, hypotonia, spastic quadriplegia, and ptosis. Notably, dermatologic anomalies such as hypopigmentation, café au lait macules, and freckling are observed, expanding the known phenotype of HAYOS. The inclusion of dermatologic features challenges our understanding of the syndrome and emphasizes the importance of further research to elucidate the molecular connections between ATAD3A mutations and dermatologic manifestations.
Mild behavioral impairment domains are longitudinally associated with pTAU and metabolic biomarkers in dementia‐free older adults
Authors: Gonzalez‐Bautista Emmanuel , Momméja Marie , de Mauléon Adelaïde , Ismail Zahinoor , Vellas Bruno , Delrieu Julien , Soto Martin Maria E. 
Published: June 2024

AbstractBACKGROUNDThe mechanisms linking mild behavioral impairment (MBI) and Alzheimer's disease (AD) have been insufficiently explored, with conflicting results regarding tau protein and few data on other metabolic markers. We aimed to evaluate the longitudinal association of the MBI domains and a spectrum of plasma biomarkers.METHODSOur study is a secondary analysis of data from NOLAN. The longitudinal association of the MBI domains with plasma biomarkers, including pTau181, was tested using adjusted linear mixed‐effects models.RESULTSThe sample comprised 359 participants (60% female, mean age: 78.3, standard deviation: 0.3 years). After 1 year, the MBI domain of abnormal perception was associated with steeper increases in plasma pTau181. Abnormal perception, decreased motivation, and impulse dyscontrol were associated with homocysteine or insulin dysregulation.DISCUSSIONApart from the association with plasma pTau181, our results suggest that MBI might also represent metabolic dysregulation, probably contributing to dementia transition among older adults with subjective cognitive decline or mild cognitive impairment.Highlights
Mild behavioral impairment (MBI) psychosis was associated with steeper increases in plasma p.
pTau could be a pharmacological target to treat agitation and psychosis symptoms.
MBI domains were linked to metabolic dysregulation involving insulin and homocysteine.
Mode of Onset Modifies the Effect of Time to Endovascular Reperfusion on Clinical Outcomes after Acute Ischemic Stroke: An Analysis of the DAWN Trial
Authors: Nogueira Raul G. , Doheim Mohamed F. , Jadhav Ashutosh P. , Aghaebrahim Amin , Frankel Michael R. , Jankowitz Brian T. , Budzik Ronald F. , Bonafe Alain , Bhuva Parita , Yavagal Dileep R. , Hanel Ricardo A. , Hassan Ameer E. , Ribo Marc , Cognard Christophe , Sila Cathy A. , Jenkins Paul , Smith Wade S. , Saver Jeffrey L. , Liebeskind David S. , Jovin Tudor G. , Haussen Diogo C. 
Published: June 2024

ObjectiveWe aimed to assess the impact of time to endovascular thrombectomy (EVT) on clinical outcomes in the DAWN trial, while also exploring the potential effect modification of mode of stroke onset on this relationship.MethodsThe association between every 1‐h treatment delay with 90‐day functional independence (modified Rankin Scale [mRS] score 0–2), symptomatic intracranial hemorrhage, and 90‐day mortality was explored in the overall population and in three modes of onset subgroups (wake‐up vs. witnessed vs. unwitnessed).ResultsOut of the 205 patients, 98 (47.8%) and 107 (52.2%) presented in the 6 to 12 hours and 12 to 24 hours time window, respectively. Considering all three modes of onset together, there was no statistically significant association between time last seen well to randomization with either functional independence or mortality at 90 days in either the endovascular thrombectomy (mRS 0–2 1‐hour delay OR 1.07; 95% CI 0.93–1.24; mRS 6 OR 0.84; 95% CI 0.65–1.03) or medical management (mRS 0–2 1‐hour delay OR 0.98; 95% CI 0.80–1.14; mRS 6 1‐hour delay OR 0.94; 95% CI 0.79–1.09) groups. Moreover, there was no significant interaction between treatment effect and time (p = 0.439 and p = 0.421 for mRS 0–2 and 6, respectively). However, within the thrombectomy group, the models that tested the association between time last seen well to successful reperfusion (modified Treatment in Cerebral Infarction ≥2b) and 90‐day functional independence showed a significant interaction with mode of presentation (p = 0.013). This appeared to be driven by a nominally positive slope for both witnessed and unwitnessed strokes versus a significantly (p = 0.018) negative slope in wake‐up patients. There was no association between treatment times and symptomatic intracranial hemorrhage.InterpretationMode of onset modifies the effect of time to reperfusion on thrombectomy outcomes, and should be considered when exploring different treatment paradigms in the extended window. ANN NEUROL 2024;96:356–364
Ambient Air Processed Inverted Inorganic Perovskite Solar Cells with over 21 % Efficiency Enabled by Multifunctional Ethacridine Lactate
Authors: Li Tianxiang , Li Wan , Wang Kun , Tong Yu , Wang Hao , Chen Yali , Qi Heng , Kang Ziyong , Wang Hongqiang 
Published: June 2024

AbstractAll‐inorganic cesium lead triiodide perovskites (CsPbI3) have attracted increasing attention due to their good thermal stability, remarkable optoelectronic properties, and adaptability in tandem solar cells. However, N2‐filled glovebox is generally required to strictly control the humidity during film fabrication due to the moisture‐induced black‐to‐yellow phase transition, which remains a great hinderance for further commercialization. Herein, we report an effective approach via incorporating multifunctional ethacridine lactate (EAL) to mitigate moisture invasion and enable the fabrication of efficient inverted (p‐i‐n) CsPbI3 perovskite solar cells (PSCs) under ambient condition. It is revealed that the lactate anions accelerate the crystallization of CsPbI3, shortening the exposure time to moisture during film fabrication. Meanwhile, the conjugated backbone and multiple functional groups in the ethacridine cations can interact with I− and Pb2+ to reduce the undesired defects, stabilize the perovskite structure and facilitate the charge transport in the film. Moreover, EAL incorporation also leads to better energy alignment, thus favoring charge extraction at both upper and bottom interfaces. Consequently, the device efficiency and stability are enormously enhanced, with the champion efficiency reaching 21.08 %. This even surpasses the highest value reported for the devices fabricated in glovebox, representing a record efficiency of inverted all‐inorganic PSCs.
Catalytic Asymmetric Synthesis of Unnatural Axially Chiral Biaryl δ‐Amino Acid Derivatives via a Chiral Phenanthroline‐Potassium Catalyst‐Enabled Dynamic Kinetic Resolution
Authors: Cen Shouyi , Li Shan‐Shan , Zhao Yin , Zhao Mei‐Xin , Zhang Zhipeng 
Published: June 2024

AbstractAxially chiral biaryl δ‐amino acids possess significantly different conformational properties and chiral environment from centrally chiral amino acids, therefore, have drawn considerable attention in the fields of synthetic and medicinal chemistry. Herein, a novel chiral phenanthroline‐potassium catalyst has been developed by constructing a well‐organized axially chiral ligand composed of one 1,10‐phenanthroline unit and two axially chiral 1,1′‐bi‐2‐naphthol (BINOL) units. In the presence of this catalyst, good to excellent yields and enantioselectivities (up to 99 % yield, 98 : 2 er) have been achieved in the ring‐opening alcoholytic dynamic kinetic resolution of a variety of biaryl lactams, thereby providing an efficient protocol for catalytic asymmetric synthesis of unnatural axially chiral biaryl δ‐amino acid derivatives.
Study on the synthesis and properties of a new fluorine‐containing copolyarylate
Authors: Wang Zhoufeng , Long Xiubo , Wang Bolin , Cheng Guojun , Ding Guoxin , Liu Yingying , Yao Wenlong 
Published: June 2024

AbstractA range of new fluorine‐containing copolyarylates were successfully produced through interfacial polymerization using hexafluorobisphenol A (BPAF) featuring a symmetric trifluoromethyl group structure, bisphenol B (BPB), and two acyl chloride monomers as raw materials. The results indicated that the synthesized amorphous copolyarylates exhibited good solubility, with number average molecular weights (Mn) of 19,000–44,000 g/mol, weight average molecular weights (Mw) of 66,000–159,000 g/mol, and intrinsic viscosities of 0.66–1.19 dL/g. The thermal stability of copolyarylates increased with the increase of BPAF monomer content (0~100%), which was manifested by the linear increase of glass transition temperature (Tg) from 201.6 to 237.1°C, and the increase of 5% thermogravimetric weight loss temperature (T5%) from 474.1 to 491.5°C. The tensile strength of copolyarylates ranged from 52.63 to 59.93 MPa, the tensile modulus ranged from 1102.08 to 1502.84 MPa, and the elongation at break ranged from 32.0 to 75.5%. In addition, the copolyarylates had good dielectric properties with a dielectric constant of 2.58–3.75 at 107 Hz and a dielectric loss tangent of 0.021–0.028.
Genome‐wide patterns of homoeologous gene flow in allotetraploid coffee
Authors: Ortiz Andre J. , Sharbrough Joel 
Published: June 2024

AbstractPremiseAllopolyploidy—a hybridization‐induced whole‐genome duplication event—has been a major driver of plant diversification. The extent to which chromosomes pair with their proper homolog vs. with their homoeolog in allopolyploids varies across taxa, and methods to detect homoeologous gene flow (HGF) are needed to understand how HGF has shaped polyploid lineages.MethodsThe ABBA‐BABA test represents a classic method for detecting introgression between closely related species, but here we developed a modified use of the ABBA‐BABA test to characterize the extent and direction of HGF in allotetraploid Coffea arabica.ResultsWe found that HGF is abundant in the C. arabica genome, with both subgenomes serving as donors and recipients of variation. We also found that HGF is highly maternally biased in plastid‐targeted—but not mitochondrial‐targeted—genes, as would be expected if plastid–nuclear incompatibilities exist between the two parent species.DiscussionTogether, our analyses provide a simple framework for detecting HGF and new evidence consistent with selection favoring overwriting of paternally derived alleles by maternally derived alleles to ameliorate plastid–nuclear incompatibilities. Natural selection therefore appears to shape the direction and intensity of HGF in allopolyploid coffee, indicating that cytoplasmic inheritance has long‐term consequences for polyploid lineages.