bluuebunny/crossref_metadata_2025_split huggingface dataset:
Postchemotherapy histological analysis of major intrahepatic vessels for reversal of attachment or invasion by colorectal liver metastases
Authors: Tanaka Kuniya , Kumamoto Takafumi , Nojiri Kazunori , Takeda Kazuhisa , Endo Itaru 
Published: September 2011

AbstractBACKGROUND:Although tumor reduction via present‐day prehepatectomy chemotherapy can render initially unresectable disease potentially resectable, little is known about the effects of such chemotherapy on liver metastases with known attachment to or invasion of major intrahepatic vessels. We histologically assessed the relationships of liver tumors to major intrahepatic vessels after chemotherapy.METHODS:In 45 patients who underwent chemotherapy and hepatectomy with pretreatment images showing metastases attached to or invading major intrahepatic vessels, 77 metastases showed attachment to or invasion of 96 vessels.RESULTS:Using postchemotherapy imaging, 11 of 77 metastases (14.3%) appeared separated from 12 of 96 major hepatic vessels (12.5%). Among 83 vessels later examined pathologically, 29 showed direct invasion (35%) and 10 showed attachment (12%). Tumors involved another 9 vessels (11%) that were separated surgically from the tumor and preserved during hepatectomy. Tumor attachment that exceeded 25% of vessel circumferences via imaging after chemotherapy was a factor associated with pathological vascular invasion or attachment according to multivariate analysis (relative risk, 8.449; 95% confidence interval, 1.961‐36.415; P = .0042).CONCLUSIONS:Liver metastasis attachment to or invasion of major intrahepatic vessels is difficult to eradicate even with otherwise effective chemotherapy. Cancer 2012;. © 2011 American Cancer Society.
Regional and subcellular distribution of the receptor‐targeting protein PIST in the rat central nervous system
Authors: Chen Annie , Göβling Enno K. , Witkowski Leora , Bhindi Amar , Bauch Carola , Roussy Geneviève , Sarret Philippe , Kreienkamp Hans‐Jürgen , Stroh Thomas 
Published: September 2011

AbstractProtein interacting specifically with Tc10, PIST, is a Golgi‐associated sorting protein involved in regulating cell‐surface targeting of plasma membrane receptors. The present study provides the first comprehensive description of PIST distribution in the mammalian central nervous system and of its subcellular localization by immunocytochemistry. PIST is distributed widely throughout the neuraxis, predominantly associated with neuronal cell bodies and dendrites. In hippocampal neurons, in vitro and in situ, PIST displayed a patchy subcellular distribution in an area surrounding the nucleus and extending into one of the major dendrites. By colocalization with the trans‐Golgi marker TGN38, we were able to show that PIST is associated largely but not exclusively with the trans‐Golgi network in central neurons. High or moderate to high levels of PIST‐like immunoreactivity were found in cortical areas, in particular in layer V of the neocortex. The motor cortex was most strongly labeled. Also, the piriform and insular cortices displayed strong PIST labeling. In the hippocampus, CA2 but not CA1 or CA3 pyramidal cells displayed strong PIST‐labeling, extending into their apical dendrites. In the thalamus, ventrolateral and laterodorsal nuclei were most strongly stained, whereas in the hypothalamus the supraoptic nucleus stood out with strong immunoreactivity. Strikingly, in the brainstem all cranial nerve motor nuclei were PIST‐positive at varying levels, which is in keeping with the prominent expression of PIST in forebrain motor areas. This selective distribution of PIST suggests that the protein serves distinctive roles in specific neuronal populations, establishing functionally distinct zones, for instance, in the hippocampus. J. Comp. Neurol. 520:889–913, 2012. © 2011 Wiley Periodicals, Inc.
Behavior of a periodic chromatic test with an achromatic Ronchi grating as a background
Authors: Montañana I. Tortajada , Colomer J. Montalvá , Rico M. Aguilar 
Published: September 2011

AbstractThe aim of this article is to study the influence of an achromatic Ronchi grating (white and black stripes) used as a background, over a periodic chromatic test (red or green). Depending on the grating frequency, two parameters were used to study this influence: modulation ratio and grating contrast. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2012
Dual cryptography authentication protocol and its security analysis for radio frequency identification systems
Authors: Ning Huansheng , Liu Hong , Yang Laurence T. , Zhang Yan 
Published: September 2011

SUMMARYThe open radio frequency identification (RFID) air interface may suffer from severe threats that make security problem become a critical issue for RFID systems and applications. This paper proposes a dual cryptography authentication protocol (DCAP) for RFID systems. DCAP partitions randomly the tag identifier into two partial identifiers that are used in the forward link and in the backward link, respectively. The protocol applies hash function and shared‐key encryption algorithm to safeguard both forward and backward links and provides a three‐round authentication mode on each tag and reader in a session. Then, authentication is carried out by the primary, secondary, and final verifications. For a formal analysis, a graphical method Colored Petri Nets is applied to model and analyze the correctness of DCAP. We prove that the protocol owns tag anonymity and forward security and has the capability to resist major attacks such as replay, reader forgery, and tag forgery. Finally, the performance in terms of storage, communication overhead, and computation load is evaluated to demonstrate that the protocol has modest complexity and high efficiency. Copyright © 2011 John Wiley & Sons, Ltd.
Multi‐level simultaneous multithreading scheduling to reduce the temperature of register files
Authors: Chen Chih‐Yuan , Ciou Jhong‐Yi , Chang Rong‐Guey 
Published: September 2011

SUMMARYSimultaneous multithreading (SMT) processors can exploit thread‐level parallelism and at the same time exploit instruction‐level parallelism for multiple‐issue, dynamically scheduled processors. As they have been widely used in embedded systems, reducing their highest temperature has become very important. According to our observation, the register file is always one of the hottest parts of an embedded system. Thus, we present a smart scheduling that can cool an SMT processor effectively by controlling the temperatures of its register files without causing significant performance loss. The proposed approach is fourfold, thus allowing an operating system to dynamically adjust the running workloads based on the temperature threshold and the real‐time constraint. Our experiment was performed on the M‐Sim and HotSpot simulators to evaluate the power of functional units and the temperature impact for SMT processors. In contrast with the round‐robin scheduling, the proposed approach can reduce thermal emergency time by 16.1 and 9.38% of the integer register file and the floating point register file, respectively. Moreover, the proposed approach only degrades performance by 8.8%, which is better than the 22.1% of the throttling approach. Copyright © 2011 John Wiley & Sons, Ltd.
Optimized composition of performance‐aware parallel components
Authors: Kessler C. , Löwe W. 
Published: September 2011

SUMMARYWe describe the principles of a novel framework for performance‐aware composition of sequential and explicitly parallel software components with implementation variants. Automatic composition results in a table‐driven implementation that, for each parallel call of a performance‐aware component, looks up the expected best implementation variant, processor allocation and schedule given the current problem, and processor group sizes. The dispatch tables are computed off‐line at component deployment time by an interleaved dynamic programming algorithm from time‐prediction meta‐code provided by the component supplier. Copyright © 2011 John Wiley & Sons, Ltd.
Agent‐based simulation of cooperative defence against botnets
Authors: Kotenko Igor , Konovalov Alexey , Shorov Andrey 
Published: September 2011

SUMMARYThe paper outlines a framework and software tool intended for simulation of cooperative defence mechanisms against botnets. These framework and software tool are based on agent‐oriented approach and packet‐level network simulation. They are intended to evaluate and compare different cooperative distributed attacks and defence mechanisms. Botnet and defence components are represented in the paper as a set of collaborating and counteracting agent teams. Agents are supposed to collect information from various network sources, operate different situational knowledge, and react to actions of other agents. The paper describes the results of experiments aimed to investigate botnets and distributed denial of service defence mechanisms. We explore various botnet attacks and counteraction against them on the example of defence against distributed denial of service attacks. Copyright © 2011 John Wiley & Sons, Ltd.
Thermodynamics of (Ga, In)‐Sb‐O‐Si and impact on dewetting process
Authors: Sylla L. , Duffar T. 
Published: September 2011

AbstractA thermodynamic study is performed for the systems (Ga or In)‐Sb‐O‐Si in order to better understand the difference observed during dewetting experiments of GaSb and InSb in silica ampoules. Results show that the melts can be considered as non reactive toward silica. When the atmosphere is clean (≤ 1 ppm O2), no oxide is formed, while, under oxidising atmosphere, oxides exist above the melting point of the antimonide and are known to increase the wetting angle of the melt on the crucible. However the temperature range for oxide stability is smaller in the case of InSb and this may explain why dewetting is easy for GaSb in presence of oxygen, while it is difficult for InSb. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Structural evolution of barite particles using a polymer with double hydrophilic ionic moieties as additive
Authors: Zhang Xiaohui , Yan Feng‐Wen , Guo Cun‐Yue , Li Fengbo , Yuan Guoqing 
Published: September 2011

AbstractBaSO4 particles with uniform size distribution were obtained using polymer with double hydrophilic ionic moieties as crystal growth modifier. Based on the difference of the dissociation constant pKa between both functional groups, structural evolution of barium sulfate from spherical aggregates to round tablets was conveniently achieved by merely adjusting the pH values of solution. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On the performance and fairness of dynamic channel allocation in wireless mesh networks
Authors: Bakhshi Bahador , Khorsandi Siavash 
Published: September 2011

SUMMARYChannel assignment in multichannel multiradio wireless mesh networks is a powerful resource management tool to exploit available multiple channels. Channels can be allocated either statically on the basis of long‐term steady state behavior of traffic or dynamically according to actual traffic demands. It is a common belief that dynamic schemes provide better performance; however, these two broad classes of channel allocation schemes have not been compared in detail. In this paper, we quantify the achievable performance gain and fairness improvement through anoptimaldynamic channel allocation scheme. We develop optimal algorithms for a dynamic and three static schemes using mixed integer linear programming and compare them in the context of QoS provisioning, where network performance is measured in terms of acceptance rate of QoS sensitive traffic demands.Our extensive simulations show that static schemes should optimize channel allocation for long‐term traffic pattern and maintain max–min fairness to achieve acceptable performances. Although the dynamic and max–min fair static schemes accomplish the same fairness, the dynamic channel allocation outperforms the static scheme about 10% in most cases. In heavily overloaded regimes, especially when network resources are scarce, both have comparable performances, and the max–min fair scheme is preferred because it incurs less overhead. Copyright © 2011 John Wiley & Sons, Ltd.
Gene induction in mature oligodendrocytes with a PLP‐tTA mouse line
Authors: Inamura Naoko , Sugio Shouta , Macklin Wendy B. , Tomita Koichi , Tanaka Kenji F. , Ikenaka Kazuhiro 
Published: September 2011

AbstractMature oligodendrocytes are critical for myelin maintenance. To understand the molecular basis for this, genetic manipulation of mature oligodendrocytes is needed. Here we generated a mature oligodendrocyte tTA (tetracycline‐controlled transcriptional activator) mouse line which, in combination with a tTA‐dependent promoter line driving the expression of the desired transgene, can be used for gain‐of‐function studies. We used an oligodendrocyte promoter, the mouse proteolipid protein (PLP) promoter, to express mammalianized tTA, and generated a PLP‐mtTA mouse line. In adults, mtTA mRNA was predominantly detected in brain white matter where it co‐localized with PLP mRNA. mtTA‐mediated gene induction was confirmed by crossing to mice with a tTA‐dependent promoter driving expression of yellow fluorescent protein (tetO‐YFP mice). YFP induction in PLP‐mtTA::tetO‐YFP mice was consistent with PLP expression in adult mature oligodendrocytes and premyelinating‐stage myelinating oligodendrocytes. This PLP‐mtTA mouse line is the first to enable gain‐of‐function studies in mature oligodendrocytes with the tet system. genesis 50:424–428, 2012. © 2011 Wiley Periodicals, Inc.
Development of fault point locating system for underground transmission lines using optical fiber current sensors
Authors: Kurosawa Kiyoshi , Kondo Reishi , Nasukawa Shinsuke , Yamaguchi Tatsushi , Amano Kazuo 
Published: September 2011

AbstractFault point locating systems based on surge current detection have recently been used for fast recovery of underground transmission lines from faults. Electromagnetic induction type sensors have mainly been used for the detection of surge current. However, they are susceptible to electromagnetic noise which causes unstable system operation. To solve this problem, Tokyo Electric Power Co., Toko Electric Corporation, and Fujikura Ltd. jointly developed a new system using optical fiber current sensors. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 178(1): 21–28, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.20981
A study on adaptive noise canceller using linear phase filter
Authors: Kobayashi Masaki , Wang Chi 
Published: September 2011

AbstractIn this paper, we propose a new adaptive noise canceller using a linear phase filter. The linear model in which an arbitrary signal is defined by the output signal of a linear system at the white signal input is used. The noise is suppressed by the estimated linear system and the signal‐to‐noise ratio is improved. At this point, to minimize the distortion of the signal due to the nonlinearity of the phase shift, the linear phase filter has been newly introduced. The transfer function of the linear system is an arbitrary minimum phase rational transfer function that has poles and zeros. It has the feature of not being specified for all pole models. The adaptive algorithm is a gradient‐based algorithm with few computational complexities. The features of the proposed adaptive noise canceller are that the inverse filter of the adaptive filter is stable, the convergence of the algorithm is guaranteed, the distortion of the signal is minimal, and there is no restriction on the transfer function of the linear system. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 178(1): 50–55, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21116
Cover Picture: Eur. J. Immunol. 10/11
Authors: Vérollet Christel , Charrière Guillaume M. , Labrousse Arnaud , Cougoule Céline , Le Cabec Véronique , Maridonneau‐Parini Isabelle 
Published: September 2011

AbstractThe cover shows human monocyte‐derived macrophages migrating into gelled collagen I using the mesenchymal migration mode as described by Maridonneau–Parini and colleagues in their review (pp. 2805–2813). At the tip of the cell protrusions, 3D podosomes form and there is an elongated and protrusive cell shape, which is characteristic of this migration mode. The macrophages were fixed, permeabilized and stained with phalloidin for F‐actin (green) and show accumulation of F‐actin at the 3D podosomes; DAPI staining identifies the nuclei (blue). The image is a projection of five z‐sections of 0.4 μm, obtained by confocal microscopy and was provided by Véronique Le Cabec.
Transition‐Metal‐Mediated Routes to 3,3‐Disubstituted Oxindoles through Anilide Cyclisation
Authors: Klein Johannes E. M. N. , Taylor Richard J. K. 
Published: September 2011

AbstractThis review describes transition‐metal‐catalysed and ‐mediated processes for the preparation of oxindoles from anilides through C(3)–C(3a) bond formation. Traditional methods, such as the Heck reaction, and recent developments, including direct Ar–H coupling processes, are presented, as are applications in natural product synthesis.
Stereoselective Total Synthesis of Polyrhacitides A and B
Authors: Yadav J. S. , Rajendar Goreti 
Published: September 2011

AbstractTwo aliphatic polyketide natural products, polyrhacitides A and B, have been synthesized in a concise and highly stereoselective manner. The synthesis involved an auxiliary‐based acetate aldol reaction to generate the initial stereogenic center and an iterative Wittig reaction, intramolecular oxa‐Michael addition, and chelation‐controlled reduction reaction as the key steps to generate additional stereocenters. One‐pot acid‐mediated global deprotection and cyclization reactions shape the final bicyclic lactone core.
Versatile Launch Pad for Facile Functionalization of Cavitands
Authors: Aakeröy Christer B. , Chopade Prashant D. , Schultheiss Nate , Desper John 
Published: September 2011

AbstractSuzuki–Miyaura cross‐coupling reactions have been utilized for the derivatization of the upper‐rim of cavitands, but unfortunately, only a relatively small number of suitable, inexpensive boronic acids are available. Herein, we report the synthesis and structure determination of a tetraboronic pinacolyl ester functionalized cavitand, which has been successfully employed in high‐yielding coupling reactions with iodoarenes covering a range of functional groups, thereby demonstrating the versatility and chemoselectivity of this platform.
Highly Enantioselective Michael Additions of Isobutyraldehyde to Nitroalkenes Promoted by Amphiphilic Bifunctional Primary Amine‐Thioureas in Organic or Aqueous Medium
Authors: Ma Zhi‐Wei , Liu Yu‐Xia , Zhang Wen‐Jing , Tao Yan , Zhu Yu , Tao Jing‐Chao , Tang Ming‐Sheng 
Published: September 2011

AbstractA novel class of chiral amphiphilic bifunctional thioureas based on a beyerane scaffold and each containing a primary amino group were designed and synthesized from the readily available natural product isosteviol. The thioureas were shown to be effective for catalyzing asymmetric Michael additions between isobutyraldehyde and nitroalkenes. The chiral thiourea 1a furnished S enantiomers, whereas 1b afforded R enantiomers, both with high yields (up to 92 %) and high to excellent enantioselectivities (up to 98 %). Furthermore, the reactions proceeded smoothly both in organic solvents and in water under mild conditions.
An Experimental Investigation of Verbal Expression of Emotion in Anorexia and Bulimia Nervosa
Authors: Davies Helen , Swan Nicola , Schmidt Ulrike , Tchanturia Kate 
Published: September 2011

AbstractObjectiveThis study aims to use an experimental design to investigate verbal expression of emotion in anorexia nervosa (AN) and bulimia nervosa (BN).MethodForty‐two patients with AN, 26 patients with BN and 34 healthy controls (HCs) were videoed talking about discrete emotional experiences. Talks were analysed using the Linguistic Inquiry and Word Count. Participants also completed the Emotion Regulation Questionnaire (ERQ).ResultsPeople with AN used fewer words when describing their emotional experiences and fewer positive affect words than HCs. People with BN were indistinguishable from HCs. Both ED groups had higher scores on the suppression subscale of the ERQ compared with HCs. Suppression was negatively correlated with negative verbal expression.DiscussionThis study highlights differences between AN and BN in emotion expression. It supports a model of AN, which highlights emotion inhibition as a maintaining factor of the illness. Methods of emotion regulation in EDs may contribute to increased negative mood and poorer social functioning. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.
A Short and Efficient Synthesis of a Novel Diarylheptanoid Isolated from Pleuranthodium Racemigerum
Authors: Chang Ching‐Yao 
Published: September 2011

AbstractThe first total synthesis of the linear diarylheptanoid 1‐(4″‐methoxyphenyl)‐7‐(4′‐hydroxyphenyl)‐(E)‐hept‐2‐ene, which has a uniquely nonconjugated olefin, was achieved. The synthetic route employed an olefin cross‐metathesis as a key step. Beginning with commercially available 3‐(4‐hydroxyphenyl)propan‐1‐ol, the final product was made in three steps with a 52% yield.
One‐pot New Barbituric Acid Derivatives Derived from the Reaction of Barbituric Acids with BrCN and Ketones
Authors: Hosseini Yaser , Rastgar Saeed , Heren Zerrin , Büyükgüngörc Orhan , Pesyan Nader Noroozi 
Published: September 2011

AbstractReaction of cyclic β‐dicarbonyl compounds such as pyrimidine‐(1H,3H,5H)‐2,4,6‐trione (BA), 1,3‐dimethyl pyrimidine‐(1H,3H,5H)‐2,4,6‐trione (DMBA) and 2‐thioxo‐pyrimidine‐(1H,3H,5H)‐4,6‐dione (TBA) with cyanogen bromide in acetone and 2‐butanone in the presence of triethylamine afforded a new class of stable heterocyclic spiro[furo[2,3‐d]pyrimidine‐6,5′‐pyrimidine]2,2′,4,4′,6′(3H,3′H,5H)‐pentaones (dimeric forms of barbiturate) at 0 °C and ambient temperature. Structure elucidation was carried out by X‐ray crystallographic, 1H NMR, 13C NMR, two dimensional NMR, FT‐IR spectra, mass spectrometry and elemental analysis. The mechanism of product formation is discussed. The reaction of DMBA with cyanogen bromide in the presence of triethylamine also afforded trimeric form of barbiturate of uracil derivatives in good yield. The reaction of selected acyclic β‐dicarbonyl compounds with cyanogen bromide in the presence of triethylamine in acetone and/or diethyl ether has also been investigated under the same condition. Diethyl malonate and ethyl cyanoacetate brominated and also ethyl acetocetate both brominated and cyanated on active methylene via cyanogen bromide.