bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphor‐Loaded Triboelectric Film‐Based Multipurpose Triboelectric Nanogenerators for Highly‐Efficient Energy Harvesting, Sensing, and Self‐Illumination Applications
Authors: Paranjape Mandar Vasant , Lee Jun Kyu , Manchi Punnarao , Graham Sontyana Adonijah , Kurakula Anand , Kavarthapu Venkata Siva , Yu Jae Su 
Published: June 2024

AbstractA novel approach is proposed for combining phosphor materials with triboelectric nanogenerators (TENGs) for mechanical energy harvesting and illumination applications. For this purpose, strongly reddish‐orange‐emitting Ba0.5Sr0.5Nb2O6:0.25 mol Eu3+ (BSNb:0.25Eu) phosphor materials are synthesized. The photoluminescence properties of the synthesized BSNb:0.25Eu are analyzed. The synthesized BSNb:0.25Eu is utilized as a dielectric filler inside a polydimethylsiloxane polymeric film due to its high dielectric properties to improve the overall dielectric properties of the composite film (CF). TENG devices are fabricated using phosphor‐loaded CFs as the tribonegative layer, transparent polyvinyl alcohol as the tribopositive layer, and aluminum as the conductive electrode. All the TENGs operate in a contact‐separation mode, and the highest electrical output is attained by optimizing the phosphor filler concentration in the CF. The optimized TENG exhibits excellent stability in long‐term operational tests, under varying harsh ambient temperatures. Indium tin oxide sputtered on both triboelectric films as an electrode and combined with a transparent hard substrate to obtain a fully transparent TENG. A self‐illuminating TENG (SI‐TENG) is fabricated by integrating near‐ultraviolet light‐emitting diodes between two identical TENGs. The SI‐TENG can harvest the mechanical energy available in the surrounding environment and illuminate it as a light source. Additionally, the proposed phosphor‐loaded polymer films can be employed for optical thermometry and mechanical energy harvesting via SI‐TENG on a large scale.
In Situ Hybrid Crosslinking Polymerization of Nanoparticles for Composite Polymer Electrolytes to Achieve Highly‐Stable Solid Lithium–Metal Batteries
Authors: Mu Kexin , Dong Weiliang , Xu Weijian , Song Zhennuo , Wang Ruixue , Wu Liuyishun , Li Hong , Liu Qiang , Zhu Caizhen , Xu Jian , Tian Lei 
Published: June 2024

AbstractThe composite solid electrolyte, which combines the advantages of inorganic conductors and organic polymer electrolytes, has become a crucial strategy for the construction of solid‐state batteries. However, the physical deposition and agglomeration of traditional composite fillers seriously affect their structural uniformity and ion transport performance, and the construction of uniform and stable composite electrolytes is still an insurmountable challenge. Herein, a strategy of in situ hybrid crosslinking polymerization of TiO2 nanoparticles is proposed for highly stable polymer composite electrolytes (NHCPE) with an ultrahigh ionic conductivity of 1.74 × 10−3 S cm−1 at 25 °C, and a high lithium‐ion transference number of 0.725. These properties enable the composed lithium symmetric battery to be stably deposited/plating off at 0.5 mA cm−2 for more than 1000 h. Moreover, the assembled LFP|PDOL@nanoTiO2|Li battery exhibits a superior specific discharge capacity of 142.6 mAh g−1 at 1 C and 25 °C, and an ultrahigh capacity retention rate of 90% after 1000 cycles. The proposed PDOL@nanoTiO2 NHCPE greatly inhibits the defects of easy agglomeration of composite electrolytes, solves the problems of easy decomposition, low thermal stability, and poor safety of polyether electrolytes, and opens up a new way for the design and industrial application of high‐stability composite polymer electrolytes.
Solar Heating Modulated by Evaporative Cooling Provides Intermittent Temperature Gradients for Ionic Thermoelectric Supercapacitors
Authors: Liao Mingna , Zhao Dan , Jonsson Magnus P 
Published: June 2024

AbstractSolar heating is important for many applications but less attractive for concepts requiring intermittent heating, such as ionic thermoelectric supercapacitors (ITESCs). However, the heating process even at constant solar illumination can be converted to temperature oscillations through water infiltration and evaporation. Here, this process is demonstrated for a carbon nanotube‐cellulose membrane and used to induce temporally varying temperature gradients across an ITESC, which enables continuous operation through repeated charge and discharge cycles. A temperature variation of 10 K can be generated on the top electrode, which leads to a variation in the temperature difference across the ITESC of 7.5 K. Precise control over charge and discharge durations can be achieved by adjusting the volume and interval of the added water. The concept of temporarily adjusting temperatures by evaporative cooling may be extended to create intermittent heating also for other heat sources that are typically constant.
Mechanochemistry Drives Alkene Difunctionalization via Radical Ligand Transfer and Electron Catalysis
Authors: Patra Subrata , Nandasana Bhargav N. , Valsamidou Vasiliki , Katayev Dmitry 
Published: June 2024

AbstractA general and modular protocol is reported for olefin difunctionalization through mechanochemistry, facilitated by cooperative radical ligand transfer (RLT) and electron catalysis. Utilizing mechanochemical force and catalytic amounts of 2,2,6,6‐tetramethylpiperidinyloxyl (TEMPO), ferric nitrate can leverage nitryl radicals, transfer nitrooxy‐functional group via RLT, and mediate an electron catalysis cycle under room temperature. A diverse range of activated and unactivated alkenes exhibited chemo‐ and regioselective 1,2‐nitronitrooxylation under solvent‐free or solvent‐less conditions, showcasing excellent functional group tolerance. Mechanistic studies indicated a significant impact of mechanochemistry and highlighted the radical nature of this nitrative difunctionalization process.
Electrochemical Monitoring of Real‐Time Vesicle Dynamics Induced by Tau in a Confined Nanopipette
Authors: Chen Ke‐Le , Yu Ru‐Jia , Zhong Cheng‐Bing , Wang Ziyi , Xie Bao‐Kang , Ma Hui , Ao Mingjun , Zheng Peng , Ewing Andrew G. , Long Yi‐Tao 
Published: June 2024

AbstractThe microtubule‐associated protein tau participates in neurotransmission regulation via its interaction with synaptic vesicles (SVs). The precise nature and mechanics of tau‘s engagement with SVs, especially regarding alterations in vesicle dynamics, remain a matter of discussion. We report an electrochemical method using a synapse‐mimicking nanopipette to monitor vesicle dynamics induced by tau. A model vesicle of ~30 nm is confined within a lipid‐modified nanopipette orifice with a comparable diameter to mimic the synaptic lipid environment. Both tau and phosphorylated tau (p‐tau) present two‐state dynamic behavior in this biomimetic system, showing typical ionic current oscillation, induced by lipid‐tau interaction. The results indicate that p‐tau has a stronger affinity to the lipid vesicles in the confined environment, blocking the vesicle movement to a higher degree. Taken together, this method bridges a gap for sensing synaptic vesicle dynamics in a confined lipid environment, mimicking vesicle movement near the synaptic membrane. These findings contribute to understanding how different types of tau protein regulate synaptic vesicle motility and to underlying its functional and pathological behaviours in disease.
Effects of temperature and pressure on volatile compounds of black cumin seeds (Nigella sativa L.) oil extracted by supercritical carbon dioxide
Authors: Sakdasri Winatta , Sakulkittiyut Buntita , Ngamprasertsith Somkiat , Supang Wirasinee , Sawangkeaw Ruengwit 
Published: June 2024

AbstractThis study investigated the effects of temperature and pressure on the yield and volatile compound contents of black cumin seed oil (BCO) extracted from black cumin seeds using supercritical carbon dioxide (SCCO2). The solubility of BCO in SCCO2 increased 2.5‐fold as the pressure increased by 10 MPa. Major volatile compounds in BCO were identified using a static headspace gas chromatography–mass spectrometry (SH–GC–MS). Evidence indicated the main volatile components in SCCO2‐extracted BCO to be hexanal, p‐cymene, and thymoquinone. BCO extracted from China‐cultivated black cumin seed contained similar amounts of p‐cymene and thymoquinone. This black cumin seed is classified as the cymene/thymoquinone chemotype and is also found in Indian, Iranian, and Algerian black cumin seeds. Thymoquinone contents in BCO were more sensitive to the extraction temperature than hexanal and p‐cymene contents. The maximum oil yield of 36.28 ± 1.38 wt%, with approximately 2.0 mg of thymoquinone per milliliter of oil, was obtained at extraction temperatures of 50°C and pressures of 30 MPa. A SH–GC–MS could detect small molecules in black cumin seed oil such as hexanal. The results of this work reveal that temperature has more impact on the selectivity of volatile compounds than pressure in supercritical carbon dioxide extraction.
Autistic adults exhibit typical sensitivity to changes in interpersonal distance
Authors: Bunce Carl , Gehdu Bayparvah Kaur , Press Clare , Gray Katie L. H. , Cook Richard 
Published: June 2024

AbstractThe visual processing differences seen in autism often impede individuals' visual perception of the social world. In particular, many autistic people exhibit poor face recognition. Here, we sought to determine whether autistic adults also show impaired perception of dyadic social interactions—a class of stimulus thought to engage face‐like visual processing. Our focus was the perception of interpersonal distance. Participants completed distance change detection tasks, in which they had to make perceptual decisions about the distance between two actors. On half of the trials, participants judged whether the actors moved closer together; on the other half, whether they moved further apart. In a nonsocial control task, participants made similar judgments about two grandfather clocks. We also assessed participants' face recognition ability using standardized measures. The autistic and nonautistic observers showed similar levels of perceptual sensitivity to changes in interpersonal distance when viewing social interactions. As expected, however, the autistic observers showed clear signs of impaired face recognition. Despite putative similarities between the visual processing of faces and dyadic social interactions, our results suggest that these two facets of social vision may dissociate.
Comparison of SOX and CAPOX in patients with advanced gastric cancer after laparoscopic D2 gastrectomy: A randomized controlled trial
Authors: Liu Xin , Yan Yongjia , Lu Li , Liu Yang , Ma Jun , Wang Xi , Wang Daohan , Liu Bang , Liu Zhuo , Zhou Xueying , Cui He , Zhao Zhicheng , Li Chuan , Liu Jian , Li Weidong , Huang Qing‐Xing , Zhao Qun , Liu Tong , Fu Weihua 
Published: June 2024

AbstractBackground: Optimal adjuvant chemotherapy after laparoscopic surgery in gastric cancer (GC) patients is still undefined. We aimed to evaluate the efficacy of S‐1 plus oxaliplatin (SOX) and capecitabine plus oxaliplatin (CAPOX) in patients with GC after laparoscopic gastrectomy. Methods: A non‐inferiority randomized controlled clinical trial was performed in China. Patients with advanced GC who underwent laparoscopic D2 gastrectomy were randomly assigned to receive SOX and CAPOX regimens. Results: In total, 191 patients were screened between May 2018 and June 2019, and 140 (73.3%) were included in the modified intent‐to‐treat analysis (mITT), of whom 69 and 71 were assigned to the SOX and CAPOX groups, respectively. The SOX group had similar 3‐year overall survival (OS) and disease‐free survival to the CAPOX group. Subgroup analysis revealed significantly better OS in the SOX group for male patients ([HR] = 0.395; 95% [CI], 0.153–1.019; p = 0.045), age >60 (HR = 0.219; 95% [CI], 0.064–0.753; p = 0.016), tumors in the gastric antrum (HR = 0.273; 95% [CI], 0.076–0.981; p = 0.047), and moderately differentiated tumors (HR = 0.338; 95% [CI], 0.110–1.041; p = 0.041). There were no significant differences observed in terms of adverse events and recurrence patterns between the two groups. Conclusion: Adjuvant SOX was non‐inferior to CAPOX treatments for patients with GC who underwent curative laparoscopic D2 gastrectomy. For male patients, aged >60 years, tumors in the gastric antrum, and moderately differentiated tumors, adjuvant SOX may achieve an improvement compared with CAPOX.
Dereplication of 4‐Quinolone Alkaloids from Waltheria Indica (Malvaceae) Tissues Using Molecular Network Tools
Authors: de Medeiros Silva Raquel , de Castro Lima Murilo Marinho , Cotinguiba Fernando 
Published: June 2024

AbstractWaltheria indica (Malvaceae) is a plant popularly used in folk medicine by traditional African and indigenous communities, and in various countries worldwide, to treat general inflammation. Several biological activities of this plant have been reported, including acetylcholinesterase inhibition and potential anti‐human immunodeficiency virus (HIV), antinociceptive, analgesic, antifungal, anticancer, anti‐inflammatory, leishmanicidal, trypanocidal, antioxidant, and antibacterial activities. The chemical profile of Waltheria indica was assessed by dereplication analysis using UPLC‐MS/MS, and data acquisition was performed using chemoinformatics tools, such as Mass Spectrometry–Data Independent AnaLysis (MS‐DIAL) and MS‐FINDER softwares. The preprocessed data were sent to the GNPS to build a feature‐based molecular network (FBMN). Thirty‐three 4‐quinolone alkaloids were annotated in the extracts and fractions of stems and roots, whereas 12 were annotated in the extracts and fractions of flowers and leaves. This represents an inaugural chemical investigation study employing UPLC‐Q‐TOF‐MS/MS analysis, along with a molecular network approach, within this species and genus.
Harnessing Therapeutic Potentials of Biochanin A in Neurological Disorders: Pharmacokinetic and Pharmacodynamic Overview
Authors: Kumar Ankit , Angelopoulou Efthalia , Pyrgelis Efstratios‐Stylianos , Piperi Christina , Mishra Awanish 
Published: June 2024

AbstractBiochanin A, an isoflavone flavonoid with estrogenic activity, is naturally found in red clover and other legumes. It possesses a wide range of pharmacological properties, including antioxidant, anti‐inflammatory, anti‐apoptotic, neuroprotective, and anticancer effects. In recent years, a growing body of pre‐clinical research has focused on exploring the therapeutic potential of biochanin A in various neurological disorders, such as Alzheimer's and Parkinson's disease, multiple sclerosis, epilepsy, ischemic brain injury, gliomas, and neurotoxicity. This comprehensive review aims to shed light on the underlying molecular mechanisms that contribute to the neuroprotective role of biochanin A based on previous pre‐clinical studies. Furthermore, it provides a detailed overview of the protective effects of biochanin A in diverse neurological disorders. The review also addresses the limitations associated with biochanin A administration and discusses different approaches employed to overcome these challenges. Finally, it highlights the future opportunities for translating biochanin A from pre‐clinical research to clinical studies while also considering its commercial viability as a dietary supplement or a potential treatment for various diseases.
Asparagus officinalis Herb‐Derived Carbon Quantum Dots: Luminescent Probe for Medical Diagnostics
Authors: Yadav Nisha , Mudgal Deeksha , Mishra Manish , Mishra Vivek 
Published: June 2024

AbstractThe utilization of natural materials for the synthesis of highly fluorescent carbon quantum dots (CQDs) presents a sustainable approach to overcome the challenges associated with traditional chemical precursors. Here, we report the synthesis of novel S,N‐self‐doped CQDs (S,N@CQDs) derived from asparagus officinalis herb. These S,N@CQDs exhibit 16.7 % fluorescence quantum yield, demonstrating their potential in medical diagnostics. We demonstrate the efficacy of S,N@CQDs as luminescent probes for the detection of anti‐pathogenic medications metronidazole (MTZ) and nitazoxanide (NTZ) over concentration ranges of 0.0–180.0 μM (with a limit of detection (LOD) of 0.064 μM) and 0.25–40.0 μM (LOD of 0.05 μM), respectively. The probes were successfully applied to determine MTZ and NTZ in medicinal samples, real samples, and spiked human plasma, with excellent recovery rates ranging from 99.82 % to 103.03 %. Additionally, S,N@CQDs demonstrate exceptional efficacy as diagnostic luminescent probes for hemoglobin (Hb) detection over a concentration range of 0–900 nM, with a minimal detectability of 9.24 nM, comparable to commercially available medical laboratory diagnostic tests. The eco‐friendly synthesis and precise detection limits of S,N@CQDs meet necessary analytical requirements and hold promise for advancing diagnostic capabilities in clinical settings. This research signifies a significant step towards sustainable and efficient fluorescence‐based medical diagnostics.
Temperature Control of the Self‐Assembly Process of 4‐Aminoquinoline Amphiphile: Selective Construction of Perforated Vesicles and Nanofibers, and Structural Restoration Capability
Authors: Hisamatsu Yosuke , Toriyama Go , Yamamoto Katsuhiro , Takase Hiroshi , Higuchi Tsunehiko , Umezawa Naoki 
Published: June 2024

AbstractInvited for the cover of this issue is the group of Yosuke Hisamatsu, Naoki Umezawa, and co‐workers at Nagoya City University and Nagoya Institute of Technology. The image depicts the selective construction of perforated vesicles and nanofibers, influenced by the heating temperatures during the self‐assembly process of the 4‐aminoquinoline amphiphile. Read the full text of the article at 10.1002/chem.202400134.
Longitudinal prospective study of Sturge–Weber syndrome urine angiogenic factors and neurological outcome
Authors: Kimbrell Brooke , McKenney Kieran D. , Yeom SangEun , Iannotti Isabelle , Day Alyssa , Harmon Kelly , Sebold Alison , Smegal Lindsay , Kaplan Katherine , Daisy Cassie , Aldakhlallah Rama , Taylor Michael , Pinto Anna , Hammill Adrienne , Moses Marsha A. , Comi Anne 
Published: June 2024

AbstractObjectiveThis study identified biomarkers of neurological outcome in Sturge‐Weber syndrome (SWS) via urine angiogenic factors and captured longitudinally derived natural history data within an SWS cohort.MethodsThis longitudinal, prospective, multicentered study of 61 people with SWS aged 0.4–55 years reports port‐wine birthmark score, Neuroscore, Neuro‐Quality of Life, and urine angiogenic factors over a two‐year period.ResultsCognitive Neuroscore worsened over time for children aged 0–2 years. Male sex was associated with worsening Cognitive Function Neuroscore during the study. Age of seizure onset before 2 years was strongly associated with worse Neuroscore. Children with SWS had low Neuro‐Quality of Life related to cognitive function. Seizure severity, male sex, and earlier age of seizure onset were associated with worse Neuro‐Quality of Life in school‐aged children. Children with SWS have elevated basic fibroblast growth factor in their urine compared with controls, whereas higher vascular endothelial growth factor was associated with better Neuroscore.InterpretationThis study is the first multicenter, prospective, and longitudinal study of people with SWS. It identifies significant clinical prognostic factors such as age of seizure onset and male sex, informs symptom progression over time by age group, and suggests that further study of angiogenic mechanisms and potential biomarkers are needed.
SOMA: Observability, monitoring, and in situ analytics for exascale applications
Authors: Yokelson Dewi , Lappi Oskar , Ramesh Srinivasan , Väisälä Miikka S. , Huck Kevin , Puro Touko , Norris Boyana , Korpi‐Lagg Maarit , Heljanko Keijo , Malony Allen D. 
Published: June 2024

SummaryWith the rise of exascale systems and large, data‐centric workflows, the need to observe and analyze high performance computing (HPC) applications during their execution is becoming increasingly important. HPC applications are typically not designed with online monitoring in mind, therefore, the observability challenge lies in being able to access and analyze interesting events with low overhead while seamlessly integrating such capabilities into existing and new applications. We explore how our service‐based observation, monitoring, and analytics (SOMA) approach to collecting and aggregating both application‐specific diagnostic data and performance data addresses these needs. We present our SOMA framework and demonstrate its viability with LULESH, a hydrodynamics proxy application. Then we focus on Astaroth, a multi‐GPU library for stencil computations, highlighting the integration of the TAU and APEX performance tools and SOMA for application and performance data monitoring.
Research on the construction of multi objective coupling model and optimization method of ship form
Authors: Liu Jie , Zhang Baoji , Lai Yuyang , Fang Liqiao 
Published: June 2024

AbstractMulti‐objective optimization of ship form can effectively reduce ship energy consumption, and is one of the important research topics of green ships. However, the computational cost of numerical simulation based on computational fluid dynamics (CFD) theory is relatively high, which affects the efficiency of optimization. Traditional subjective weighting methods mostly rely on expert's experience, which affects the scientificity of optimization. This paper effectively integrates the CFD method, the improved multi‐objective optimization algorithm and the objective weighting method to build a ship form multi‐objective optimization framework. Conduct multi‐objective optimization research on resistance and seakeeping performance of a very large crude oil carrier (KVLCC) ship. The improved bare‐bones multi‐objective particle swarm optimization (IBBMOPSO) algorithm is used to obtain the pareto front, and the kernel principal component analysis (KPCA) method is used to objectively assign the weight of each target. Finally, the optimal ship form scheme with high satisfaction was obtained. The multi‐objective optimization framework constructed in this paper can provide a certain theoretical basis and technical support for the development of ship greening and digital transformation.
Is ‘too much medicine’ a guideline‐driven phenomenon? Ten years' report and reflections of the Guidelines International Network Multimorbidity Working Group
Authors: Scherer Martin , Burgers Jako S. ,   the Guidelines International Network Multimorbidity Working Group
Published: June 2024

Highlights
The Guidelines International Network Multimorbidity Working Group aims to explore how and to what extent multimorbidity can be reflected in guideline development.
Single disease guidelines contribute to ‘too much medicine’, including the abundance of diagnostic and therapeutic measures with potential harm to the patient.
The ‘less is more’ approach includes communication on patient outcomes, recommendations for deprescribing and awareness of climate impact.
Guidelines supporting person‐centred care could reduce the risk of low‐value care for multimorbid patients, which will benefit both individual and planetary health.