bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authentication and differentiation of Morinda citrifolia and Morinda coreia fruits and their commercial products
Authors: West Brett J. , Deng Shixin 
Published: May 2024

Abstract

Morinda citrifolia fruit juice, commonly known as noni juice, has become a globally popular health supplement. We have discovered, however, that Morinda coreia (syn. Morinda tinctoria) is frequently misidentified as noni in some regions. Phytochemical analyses of M. citrifolia fruit, M. officinalis root and M. coreia fruit were performed, during which specific iridoids had been identified in the latter for the first time. Comparison of results revealed that distinct phytochemical profiles may be used to identify commercial products containing authentic noni fruit powder versus the other two Morinda species. All authentic noni fruit products contain scopoletin, but those from M. coreia fruit and M. officinalis root do not. Asperuloside is absent in ripe noni fruit and in M. officinalis root, despite the presence of other iridoids. As such, a tell-tale indicator of M. coreia fruit powder is the absence of scopoletin accompanied by the presence of asperuloside. Using this information, a phytochemical survey of commercial powdered “noni” products purchased from major online retailers revealed that a high percentage of these were mislabeled and contained M. coreia fruit instead of authentic noni. As such, many consumers are not receiving what they believe they have purchased. Further, this presents potential risks as the safety and efficacy of these mislabeled products has not been evaluated in human studies.
Numerical Study on the Influence of heat generation and absorption on an incompressible hybrid nanofluid's magnetohydrodynamic (MHD) flow in a thermal system
Authors: Bauchi. Abubakar Tafawa Balewa , Hussaini Abubakar Assidiq 
Published: May 2024

Abstract

Hybrid nanofluids have been regarded as among the supreme and sophisticated nanofluids, just as demonstrated through their heat transfer characteristics as well as emerging advantages which support the determination to accelerate the rate of heat transfer. Discussion of the dual effects of heat generation/absorption in addition to thermal radiation over hybrid nanofluid is the main goal of the current paper. Using water (H2O) as the base fluid, metal (Cu) in addition to metal oxide (Al2O3) nanoparticles are combined. The purpose of heat generation and absorption is to improve the efficiency of the heat transport sensation. The necessary controlling partial differential equations are converted into dimensionless forms of ordinary differential equations using the appropriate similarity modifications. The transformed differential equations are solved using the fourth order Runge-Kutta in addition to shooting technique to find solutions to the problem. For the effect of different shape factors on the solution profiles of momentum, temperature and Nusselt quantity, the numerical results are presented as tabulated data and graphical system. The results revealed that momentum is a decreasing function with Radiation Parameter Rd, Temperature is also a decreasing functions with Eckert number Ec and Radiation Parameter Rd, likewise Nusselt number is also decreasing with Prandtl number Pr and Suction/ injection Parameter S. momentum profile fluctuates in case of Heat generation/ absorption parameter, Suction/ injection Parameter, as well as Radiation and Heat generation/ absorption parameters simultaneously.
Effect of some medicinal oil with adjuvant on maize, sunflower and sorghum productivity and associated weeds
Authors: Kamel Enas Mohamed , Elain Hesham Mohamad Ali , Ahmed Al-Badr saad , Mekky Mohammed Shams 
Published: May 2024

Abstract

The aim of this study is to evaluate the applied basil and camphor oils for weed control and phytotoxic effects on some field crops compared to chemical and mechanical weed control as well as un-weeded check. Wire house and field experiments were conducted during the period from 2020 to 2023 in the experimental farm and wire house of the Weed Research Central Laboratory at Giza Research Station, Agricultural Research Center (ARC), Egypt, in a Randomized Complete Block Design (RCBD) in four replicates. The statistical analysis of the data revealed that weed control treatments were significantly reduced the number and fresh weight of some weed species across all experiments. Improvement of maize, sunflower, and sorghum without any phytotoxic effect of essential oils or herbicides under study, except sorghum crop was sensitive to the herbicides used in the study. Camphor and basil oils were more effective on Ipomea eriocarpa, Setaria virids, Trianthema portulacastrum, Cyperus rotundus, and Cynodon dactylon. The reduction in fresh weight of weed species is about 80–100% under the low weed seed bank of the soil and sensitive weed species, and less effect under the high soil weed seed bank, especially by I. eriocarpa and S. virids, due to the emergence of these weed species after applying these oils. Finley camphor and sweet basil oil can be used for weed control under low infestation by weeds and supplemented by one hand hoeing in the case of high infestation by I. eriocarpa.
Economic Resilience: Evidence for African economies Application of a panel VAR model
Authors: Sandambi Nerhum 
Published: May 2024

Abstract

A panel VAR model was applied to analyse the economic resilience of 54 African countries from 1990–2022. Realising how exogenous shocks influence countries' ability to respond from the outset is naturally the aim of the study. Thus, the results suggest that there is a significant presence of economies based on international market expectations, which are significantly explained by the presence of exogenous shocks. On the other hand, the Impulse Response Functions help to explain the fact that 90% of African countries have economies controlled by international market expectations, which, in the presence of exogenous international market shocks, end up determining the path and behaviour of economies in the medium term. On the other hand, the results show that countries such as Botswana, South Africa, Namibia and Ghana have a greater capacity to respond in a context of uncertainty, and there are strong reasons to suggest that these countries are able to control their economies, unlike, for example, the results for Angola in a context of uncertainty, Democratic Congo and Brazzaville, Equatorial Guinea and Sierra Leone, the evidence nevertheless shows that in a context of uncertainty, exogenous shocks control and determine the economic path in the long term. These results also suggest that these economies should be characterised as economies without control by the authorities. Thus, as exogenous shocks increase, there are significant increases in the destructive capacity of these economies.
Jel Classification: c01; c21; c23; c33; F10.
A simple lysimeter soil retriever for mini lysimeters.
Authors: Gunaratnam Abhiram , McCurdy Murray , Grafton Miles , Jeyakumar Paramsothy , Davies Clive E. , Bishop Peter 
Published: May 2024

Abstract

A lysimeter-soil retriever (LSR) is a device used to retrieve the soil with minimum disturbance from lysimeters. This device makes the process of sampling intact soil layers from lysimeters easier and faster especially when a large number of lysimeters are being sampled. In this study, mini lysimeters (200 mm diameter and 25 kg weight) were used to test fertilizers. A low-cost LSR was designed to aid the accurate removal of the soil from these lysimeters. This paper describes the design and testing of the suitability of a linear actuator for this application. This study investigates the influence of soil moisture on the retrieval and structural stability of lysimeter and LSR. It was found the selected linear actuator is suitable for soil retrieving from lysimeters packed with sandy-clay loam and sand. It showed consistent performance (stroke time and maximum force) after retrieval of 400 soil blocks. Soil with a high-moisture level was more suitable as it showed lower disturbance for retrieved block, lower soil losses, minimal disturbance for roots and lower variation of soil block height and weight. The retrieval time was influenced by soil moisture level and were 48 and 52 seconds for low and high-moisture soil, respectively.
A complete overview of Puffed rice quality deterioration at Market places, usually bad smell across Bangladesh under conditions relevant to product packaging, ageing and storage.
Authors: Haque Azizul 
Published: May 2024

Abstract

Puffed rice is a popular snack product due to its taste, texture and nutritional profile. It is mainly appreciated for its crispness, lightness and qualities related to its cellular structures. Traditionally puffed rice is prepared by parboiling the paddy under the specified conditions. This is an expanded breakfast cereal obtained by high temperature short time heat treatment of salt-treated parboiled rice. This intense heat results in deformation and phase transition within the grain and delivers an expanded porous structure. Such transformations essentially govern the final puffed rice quality and its physicochemical attributes. The optimized range of microwave power level, heating lime and salt content in rice for obtaining puffed rice with maximum percentage of puffing and expansion ratio is found as 780 - 942W, 26.2 - 33.65 s and 4.6 %, respectively. Water absorption index and water solubility index were significantly affected on process of puffing. Let cool completely (rice should be dry and hard before frying). Pour enough oil into large saucepan to come 2 inches up side; heat over medium-high heat until instant-read thermometer reaches 425°F. Add a few grains of cooked rice; if oil is hot enough it will start to puff up instantly. Rice is adulterated with urea for whitening. Puffed rice (muri) is adulterated with hydrose (sodium hydrosulfite) and urea to make it whiter and bigger. Urea is also harmful to the liver and kidney. It was also obtained that both sodium chloride and potassium chloride has positive effect on expansion ratio and percentage puffing of puffed rice and the effect of sodium chloride is more than that of potassium chloride. However, in case of sensory perception, the effect of potassium chloride is more than that of sodium chloride. Hence potassium based salt substitute can be applied to parboiled rice which can significantly reduce the percentage of NaCl maintaining similar taste without affecting the puffing quality. The lighter colored puffed rice with the enhanced level of resistant starch associated with puffed rice improves the functionality of the developed puffed rice to consume directly as ready-to-eat or to be used as ready to use item in the preparation of various functional foods thereof. This is proven that under ideal storage conditions, puffed rice can retain its quality for months, although it does not have an indefinite shelf life. Overall, this research paper demonstrates the significantly impacting sources of bad smell of puffed rice inside the poly pack as well as actual category standards and improving factors of quality & usability of puffed rice.
Advanced Control Models for Glioblastoma Multiforme Management: Optimizing Drug Therapies and Adaptive Tumor Volume Regulation with Fractional-Order Mathematical Modeling
Authors: Amilo David , Sadri khadijeh , Hincal Evren 
Published: May 2024

Abstract

Glioblastoma Multiforme (GBM) is a highly aggressive and lethal form of brain tumor, presenting significant challenges in treatment and management. In this study, we propose advanced control models for the management of GBM, focusing on the optimization of drug therapies and adaptive regulation of tumor volume. Leveraging fractional-order mathematical modeling, our approach integrates mathematical modeling techniques with control theory to develop comprehensive strategies for GBM management. The proposed control models aim to optimize drug therapies by dynamically adjusting treatment parameters based on real-time tumor volume monitoring. This adaptive approach allows for personalized treatment regimens tailored to the specific characteristics of the tumor, enhancing therapeutic efficacy while minimizing adverse effects. By harnessing the capabilities of fractional-order modeling, our research provides a novel framework for advancing the management of GBM, offering new insights and strategies for combating this formidable disease
MSC Classification: 92C55, 93C95, 92B05, 35R11, 35A22, 92C50, 35Q53, 49N90.
FATORES ASSOCIADOS À DEFICIÊNCIA DE VITAMINA D EM GESTANTES E LACTANTES
Authors: Lucena Luanna Kássia Sousa de , Bezerra Danielle Soares 
Published: May 2024

Introdução: A deficiência de vitamina D (DVD) durante a gestação e a lactação pode repercutir negativamente no desenvolvimento fetal e infantil. Devido seu papel fundamental nos sistemas imunológico, cardíaco, ósseo, muscular e neural. Objetivo: Realizar uma revisão de literatura para integrar estudos que evidenciam a DVD em gestantes e lactantes, e os fatores de risco associados a essa carência. Metodologia: Foi realizado um levantamento bibliográfico entre agosto e outubro de 2021, com atualização entre outubro e novembro de 2022 através de pesquisas às bases Pubmed e Scielo, bem como às listas de referências dos artigos selecionados. Foram empregados os descritores consumo alimentar, vitamina D, deficiência de vitamina D, gestantes e lactantes, usando-se o operador booleano AND para a associação entre eles. Como critérios de inclusão foram adotados o tipo de estudo (epidemiológicos, ensaios clínicos e revisões integrativa e sistemática), o idioma (espanhol, inglês e português) e o período de publicação (2010 a 2022). Resultados: : Evidenciou-se que existem vários fatores de riscos para a inadequação do status de vitamina D em gestantes e lactantes como a baixa exposição da pele à luz solar e fatores relacionados (uso excessivo de protetor solar, menor tempo de atividades ao ar livre, clima, religião e hábitos culturais, maior escolaridade), a pigmentação mais escura da pele, o baixo consumo alimentar de vitamina D e variáveis associadas menor idade materna, primeiro trimestre gestacional, primiparidade e o excesso de tecido adiposo. Conclusões: Em gestantes e lactantes, a carência de vitamina D associa-se a distintos fatores, com destaque principalmente a baixa exposição à luz solar, a pigmentação mais escura da pele, e o excesso de tecido adiposo, sendo de extrema importância que sejam abordados com cautela, influenciando na redução da hipovitaminose D nestes grupos.
Resveratrol in the Treatment of Gynecological Cancer: Mechanisms and Therapeutic Potential
Authors: Mozafaryan Mohammad Javad , Rezaei Pouria , Masoudpoor Fardin , Bahri Amirmohammad , Samini Mohammad , Farkhondeh Tahere , Pourhanifeh Mohammad Hossein , Samarghandian Saeed 
Published: May 2024

Abstract:
Gynecological cancers, encompassing endometrial, ovarian, and cervical cancer,
pose significant challenges in clinical practice, often marked by high mortality rates
and treatment resistance. Despite advances in standard therapies, including chemoradiation
and surgery, tumor recurrence and metastasis remain formidable obstacles. In this
context, there is a pressing need to explore novel therapeutic strategies that offer improved
efficacy and reduced side effects. Herbal medicine, particularly compounds like
resveratrol, has garnered attention for its diverse biological properties, including anticancer
effects. Resveratrol, a multipotential nutraceutical, holds promise in gynecological
cancer therapy through its modulation of key cellular and molecular processes. This
review aims to provide an overview of the current status, challenges, and opportunities
in utilizing resveratrol for gynecological cancer treatment. We discuss its role in miRNA
regulation, clinical trial findings, and the development of effective formulations. By elucidating
the underlying mechanisms of resveratrol's anticancer effects and exploring innovative
delivery systems, we aim to shed light on the potential avenues for optimizing
its therapeutic benefits in gynecological cancers.
Potential Molecular Markers for Cholecystic Inflammation-Induced
Carcinogenesis Based on RNA-Seq Gene Screening
Authors: Yu Henghai , Chen Peng , Hu Ying , Liu Feng , Wei Xiaoping , Hu Mingdao 
Published: May 2024

Background::
Uncontrolled inflammation plays an important role in the initiation and
progression of tumors. The repeated circulation and continuous stimulation of gallbladder epithelium
caused by gallstones is an important risk factor for gallbladder cancer.

Methods::
To study pathogenesis, samples were collected for chronic cholecystitis caused by
gallstones and early and advanced gallbladder cancer with gallstones and subjected to RNA-seq
analysis. Gene Ontology and Kyoto Gene and Genome Encyclopedia analyses were used to elucidate
the protein–protein interaction network and identify differentially expressed genes.

Results::
Nine potential molecular markers, VTN, CHAD, AKR1C4, ABCC2, AOX1, ADH1A,
ADH1C, PLA2G2A, and CYP4F3, with elevated expression gradients in cholecystitis and early
and advanced gallbladder cancer, were identified. Using qPCR and immunohistochemistry on
clinical tissues, we confirmed three factors, VTN, CYP4F3, and AOX1, to be worthy of further
research. To demonstrate that these three genes are potential molecular markers for gallbladder
cancer, their cellular biological functions were confirmed in gallbladder cancer cell lines through
siRNA transfection.

Conclusion::
The potential molecular markers CYP4F3, VTN, and AOX1 for cholecystitis and
different stages of gallbladder cancer were identified. Further studies on differentially expressed
genes vital in gallbladder cancer progression can help provide potential targets for the early diagnosis
and treatment of gallbladder cancer.
Tuina Inhibits Chondrocyte Apoptosis by Regulating the FAK/PI3K/Akt Pathway in Rabbits with IVDD
Authors: Liu Jiayi , Liu Tong , Qian Xin , Ma Dongyang , Chen Lili , Li Ailin , Liang Xurong , Hu Zhe , Qi Chenxi , Qi Wei 
Published: May 2024

Background:
Intervertebral disc degeneration (IVDD), a key contributor to degenerative
spinal diseases such as cervical spondylosis, significantly influences the quality of life of
patients. Tuina, historically employed in the clinical management of cervical spondylosis, has
demonstrated positive therapeutic outcomes; however, the mechanism of Tuina remains unclear.

Objective:
This study examined the efficacy of Tuina in correcting the imbalanced structure of the
cervical spine and its impact on apoptotic chondrocytes within the cervical disc. The underlying
mechanisms were explored using a rabbit model of IVDD induced by dynamic and static imbalances.

Methods:
The IVDD rabbit model was established by restraining the head in a downward position
for 12 weeks (Model group). In the Tuina1 group, treatment was performed on the posterior
cervical trapezius muscle daily for 2 weeks, whereas in the Tuina2 group, treatment was performed
on both the posterior cervical trapezius and anterior sternocleidomastoid muscles daily
for 2 weeks. After treatment, X-ray, micro-computed tomography (CT), histological staining,
qRT-PCR, and western blotting were used to evaluate the mechanism by which Tuina inhibits
chondrocyte apoptosis.

Results:
The results demonstrated that Tuina treatment inhibited chondrocyte apoptosis in cervical
discs by adjusting the neck structure balance, and a more significant therapeutic effect was
observed in the Tuina2 group. Lateral cervical spine X-ray and CT scans in rabbits revealed notable
improvements in cervical spine curvature and vertebral structure in the treatment groups
compared with those in the Model group. Hematoxylin and eosin staining and TUNEL staining
further confirmed the positive impact of Tuina treatment on intervertebral disc tissue morphology
and chondrocyte apoptosis. Additionally, western blotting and immunohistochemical analysis
showed that Tuina treatment suppressed chondrocyte apoptosis by downregulating Bax and
caspase-3 while upregulating Bcl-2. Western blotting results further indicated that Tuina could
activate the FAK/PI3K/Akt signaling pathway by mediating integrin-β1.

Conclusion:
Tuina treatment inhibited chondrocyte apoptosis in cervical discs by activating the
FAK/PI3K/Akt signaling pathway, providing convincing evidence to support Tuina treatment as
a promising method for IVDD.
Integrating Network Pharmacology, Quantitative Metabolic Network
Analysis, In Vitro Experiments, and Molecular Dynamics to Explore the
Mechanism of Angelica Sinensis for Regulating Bone Metabolism
Authors: Yuan Anlei , Liu Chaoqun , Feng Wenqing , Li Beiyan , Zheng Lulu , Tian Jiaye , Yu Bin , Zhang Yanling 
Published: May 2024

Background:
Bone metabolic diseases are serious health issues worldwide. Angelica
sinensis (AS) is traditionally used in Chinese medicine for treating bone metabolism diseases
clinically. However, the mechanism of AS in regulating bone metabolism remains uncertain.

Objective:
The current investigation was structured to elucidate the potential mechanisms of AS
for modulating bone metabolism

Methods:
Firstly, targets of AS regulating bone metabolism were collected by network pharmacology. Then, the transcriptional regulation of RUNX2 was enriched as one of the key pathways
for AS to regulate bone metabolism, constructing its metabolic network. Secondly, combining
molecular docking, network efficiency, and network flux analyses, we conducted a quantitative
evaluation of the metabolic network to reveal the potential mechanisms and components of AS
regulating bone metabolism. Finally, we explored the effect of AS on the differentiation of osteoclasts from M-CSF and RANKL-induced RAW264.7 cells, as well as its impact on the osteogenic induction of MC3T3-E1 cells. We verified the mechanism and key targets of AS on bone
metabolism using qRT-PCR. Furthermore, the key component was preliminarily validated
through molecular dynamics simulation.

Results:
Quantitative metabolic network of the transcriptional regulation of RUNX2 was constructed to illustrate the potential mechanism of AS for regulating bone metabolism, indicating
that ferulic acid may be a pharmacological component of AS that interferes with bone metabolism. AS suppressed osteoclast differentiation in M-CSF and RANKL-induced RAW264.7 cells
and reversed the expressions of osteoclastic differentiation markers, including RUNX2 and SRC.
Additionally, AS induced osteogenic generation in MC3T3-E1 cells and reversed the expressions of markers associated with osteoblastic generation, such as RUNX2 and HDAC4. Molecular dynamics simulation displayed a strong binding affinity among ferulic acid, HDAC4 and
SRC.

Conclusion:
This study reveals a systematic perspective on the intervention bone mechanism of
AS by transcriptive regulation by RUNX2, guiding the clinical use of AS in treating diseases of
the skeletal system.