bluuebunny/crossref_metadata_2025_split huggingface dataset:
The predictors of response to neoadjuvant chemotherapy in advanced epithelial ovarian cancer
Authors: Yildirim Yusuf , Ertas Ibrahim Egemen , Dogan Askin , Gultekin Ozge Elmastas , Gultekin Emre 
Published: August 2011

AbstractObjectivesTo investigate the predictors of response to neoadjuvant chemotherapy (NACT) in advanced stage epithelial ovarian cancer (EOC).MethodsThirty‐five patients with nonoptimally cytoreductable at stage III–IV EOC who were treated with NACT and interval cytoreductive surgery in our center between January 2002 and February 2009 were enrolled into this retrospective pilot study. Response to NACT was evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST).ResultsAll patients received three courses platinum‐based chemotherapy [24 (69%) received pactitaxel plus carboplatin and 11 (31%) received paclitaxel plus cisplatin]. There were 12 (34%) partial response to and 23 (66%) stable disease after NACT. Optimal cytoreduction was subsequently achieved in 32 of 35 patients (91%). Among age, hystology, ovarian size, CA‐125 level, severity of pleural effusion, extensive omental disease, diaphragmatic implants, liver parenchyma metastasis, used chemotherapy regimen; only extensive omental disease was found to be predictive (P = 0.004).ConclusionsOvarian cancer patients with extensive omental disease were possibly better treated with primary cytoreductive surgery, since they were more likely to have less responsive to NACT. This finding can be used to identify patients who will get poor response to NACT and to design future tailored randomized clinical trials. J. Surg. Oncol. 2012; 105:200–205. © 2011 Wiley Periodicals, Inc.
The Formation of a Tourist Destination's Image via Information Sources: the Moderating Effect of Culture
Authors: Frías Dolores M. , Rodríguez Miguel A. , Alberto Castañeda J. , Sabiote Carmen M. , Buhalis Dimitrios 
Published: August 2011

ABSTRACTThe present study aims to outline the growing importance of culture in the field of tourism. More specifically, it highlights culture as a moderating variable in pre‐visit tourist destination image formation, through the information sources utilized by the tourist in the selection of a holiday destination (that is, travel agencies alone vs. travel agencies together with the Internet). For this purpose primary research used a multicultural sample of 371 tourists from different European countries. The results show that the formation of a destination's pre‐visit image amongst tourists, based on the information sources they use, is moderated by the level of uncertainty‐avoidance of their national cultures. Copyright © 2011 John Wiley & Sons, Ltd.
The course of mental health disorders after a disaster: Predictors and comorbidity
Authors: Meewisse Marie‐Louise , Olff Miranda , Kleber Rolf , Kitchiner Neil J. , Gersons Berthold P. R. 
Published: August 2011

AbstractCurrent longitudinal disaster studies usually focus only on posttraumatic stress disorder (PTSD), although some studies have shown that increased risks for other disorders and comorbidity is common. To obtain an insight into the course of postdisaster psychopathology, a community sample of survivors of the Enschede fireworks disaster was followed from 2–3 weeks to 4‐years postdisaster. Diagnostic interviews (Composite International Diagnostic Interview [CIDI]; World Health Organization, 1997) and childhood stressor interviews were administered at 2‐years postdisaster (n = 260); the CIDI was repeated at 4‐years postdisaster (n = 201, response rate 77.3%). At 2‐years postdisaster many survivors (40.6%) suffered from PTSD (21.8%), specific phobia (21.5%), and/or depression (16.1%). These disorders were highly comorbid. At 4‐years postdisaster, prevalence significantly diminished. Instead of full recovery, diagnostic classifications shifted in several survivors over time. This resulted in low rates of PTSD but still elevated rates of depression and specific phobia. The course of the 3 entangled disorders of PTSD, depression, and specific phobia was further studied by constructing 4 groups of survivors based on the diagnostic status at 2‐ and 4‐years postdisaster: healthy, recovered, chronic, and delayed‐onset. Initial depressive symptoms, maternal dysfunction, childhood physical abuse, and disaster exposure were found to discriminate between the groups and predict long‐term psychopathology.
LANDSAT IMAGES REVEAL TRENDS IN THE AEOLIAN DESERTIFICATION IN A SOURCE AREA FOR SAND AND DUST STORMS IN CHINA'S ALASHAN PLATEAU (1975–2007)
Authors: Wang T. , Yan C. Z. , Song X. , Li S. 
Published: August 2011

ABSTRACTThe development and reversal of aeolian desertification have been widely recognised as the dominant causes of changes in the source areas of dust storms. The Alashan Plateau, which is near China's Hexi Corridor, is one of the major dust storm source regions in northern China. To investigate the relationship between climatic and anthropogenic factors and the development of aeolian desertification, we reconstructed the temporal and spatial evolution of aeolian desertification and the underlying processes from 1975 to 2007 using Landsat images and analysed the driving forces. The results show that aeolian desertified land in the study area covered 32 847·79 km2 in 2007, amounting to 11·3 per cent of the total area, with an initial period of desertification expansion from 1975 to 2000 and a reversal of desertification from 2000 to 2007. On the basis of the analysis of effects of climate changes and human activities in the region, aeolian desertification was principally driven by human activities in this area; climatic variations had little effect on the area of severe desertification. Copyright © 2011 John Wiley & Sons, Ltd.
The long‐term effects of sales promotions on brand attitude across monetary and non‐monetary promotions
Authors: Yi Youjae , Yoo Jaemee 
Published: August 2011

AbstractThis study compares the influence of sales promotions on brand attitude across promotion types over time. An experiment is conducted with 154 subjects, who are exposed to test materials for 12 weeks. Evidence shows that the long‐term effects of sales promotions on brand attitude vary across deal types. Non‐monetary promotions seem to work better in eliciting consumers' favorable brand attitude than monetary promotions over time. However, such effects are moderated by consumers' deal proneness. Although monetary promotions may induce more negative effects than non‐monetary promotions, these effects are weaker for high deal‐prone consumers than for low deal‐prone consumers. © 2011 Wiley Periodicals, Inc.
The effect of consumer emotional disclosure on fairness perceptions
Authors: Lee‐Wingate Sooyeon Nikki , Corfman Kim P. 
Published: August 2011

AbstractOne way consumers cope with an unfair consumption experience is to express how they felt about it. Understandably, these disclosures are often rich with emotion. Does emotional disclosure in this context influence consumers' perceptions of fairness? Drawing hypotheses from the emotional disclosure literature, this research reveals that writing about emotions improves consumer fairness perceptions and satisfaction. However, the benefit of emotional disclosure disappears if the disclosure is solicited by the company perceived to be responsible for the unfairness and they do not offer redress. The findings lead to the recommendation that companies provide and facilitate opportunities for consumers to disclose to third parties the emotions arising from consumption experiences perceived as unfair. Implications for managing customer feedback, complaints, and negative word‐of‐mouth are discussed. © 2011 Wiley Periodicals, Inc.
Acrolein‐induced dyslipidemia and acute‐phase response are independent of HMG‐CoA reductase
Authors: Conklin Daniel J. , Prough Russell A. , Juvan Peter , Rezen Tadeja , Rozman Damjana , Haberzettl Petra , Srivastava Sanjay , Bhatnagar Aruni 
Published: August 2011

AbstractScope: Aldehydes are ubiquitous natural constituents of foods, water and beverages. Dietary intake represents the greatest source of exposure to acrolein and related aldehydes. Oral acrolein induces dyslipidemia acutely and chronically increases atherosclerosis in mice, yet the mechanisms are unknown. Because lipid synthesis and trafficking are largely under hepatic control, we examined hepatic genes in murine models of acute and chronic oral acrolein exposure.Methods and results: Changes in hepatic gene expression were examined using a Steroltalk microarray. Acute acrolein feeding modified plasma and hepatic proteins and increased plasma triglycerides within 15 min. By 6 h, acrolein altered hepatic gene expression including Insig1, Insig2 and Hmgcr genes and stimulated an acute‐phase response (APR) with up‐regulation of serum amyloid A genes (Saa) and systemic hypoalbuminemia. To test if decreased HMG‐CoA reductase activity could modify acrolein‐induced dyslipidemia or the APR, mice were pretreated with simvastatin. Statin treatment, however, did not alter acrolein‐induced dyslipidemia or hypoalbuminemia associated with an APR. Few hepatic genes were dysregulated by chronic acrolein feeding in apoE‐null mice. These studies confirmed that acute acrolein exposure altered expression of hepatic genes involved with lipid synthesis and trafficking and APR, and thus, indicated a hepatic locus of acrolein‐induced dyslipidemia and APR that was independent of HMG CoA‐reductase.Conclusion: Dietary intake of acrolein could contribute to cardiovascular disease risk by disturbing hepatic function.
Syndactyly in Pigs: A Review of Previous Research and the Presentation of Eight Archaeological Specimens
Authors: Madgwick R. , Forest V. , Beglane F. 
Published: August 2011

ABSTRACTThis paper reviews evidence for the rare condition of porcine syndactyly. It describes eight archaeological examples from Britain, Northern Ireland and France. Syndactyly refers to the partial or complete fusion of two or more adjacent phalanges on the medio‐lateral border. The degree and character of fusion are variable, but phalanges frequently unite to create a single skeletal element. This condition has been identified by veterinarians, zoologists and naturalists in individuals and populations in a range of species, but in spite of substantial research on the condition in humans and to a lesser extent cattle, it remains relatively poorly understood in other mammals. Syndactyly is generally agreed to be primarily congenital in origin, although factors affecting its incidence remain far from fully understood. In light of the general paucity of discussion of specific conditions of animal palaeopathology, this paper presents an analysis of these newly discovered syndactyle pig specimens, offers a review of research with particular reference to pigs and discusses the etiology of the condition. Copyright © 2011 John Wiley & Sons, Ltd.
Tumour necrosis factor‐α drives Alport glomerulosclerosis in mice by promoting podocyte apoptosis
Authors: Ryu Mi , Mulay Shrikant R , Miosge Nicolai , Gross Oliver , Anders Hans‐Joachim 
Published: August 2011

AbstractChronic renal failure involves the progressive loss of renal parenchymal cells. For example, Alport syndrome develops from mutated type IV collagen that fosters the digestion of glomerular basement membranes and podocyte loss, followed by progressive glomerulosclerosis, ie Alport nephropathy. Here we show that autosomal recessive Alport nephropathy in collagen 4a3‐deficient mice is associated with increased intrarenal expression of the pro‐apoptotic cytokine tumour necrosis factor‐alpha (TNF‐α) in glomerular cells including podocytes as well as in infiltrating leukocytes. We therefore hypothesized that TNF‐α contributes to Alport glomerulosclerosis by inducing podocyte apoptosis. To address this issue, we treated 4‐week‐old collagen 4a3‐deficient mice with either vehicle or the TNF‐α antagonist etanercept for a period of 5 weeks. Etanercept treatment prolonged mean survival from 68 to 81 days as compared to vehicle‐treated mice. The beneficial effect of etanercept on survival was associated with a significant improvement of the glomerulosclerosis score, proteinuria, and the glomerular filtration rate at 9 weeks of age. Etanercept treatment specifically reduced the numbers of apoptotic podocytes, increased total podocyte counts, and increased the renal mRNA expression of nephrin and podocin without affecting markers of renal inflammation. TNF‐α‐induced podocyte loss is a previously unrecognized pathological mechanism of Alport glomerulosclerosis, and TNF‐α blockade might be a therapeutic option to delay the progression of Alport nephropathy and potentially of other forms of glomerulosclerosis. Copyright © 2011 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Scaling‐up of the dispersion process of nanoparticle‐agglomerates in epoxy resin with an innovative continuous ultrasonic flow‐through‐cell dispersion system
Authors: Englert M. , Bittmann B. , Haupert F. , Schlarb A.K. 
Published: August 2011

AbstractThermosets reinforced with inorganic nanoparticles show numerous benefits over the unreinforced polymer. However, to achieve reinforcement the nanoparticles have to be well separated and distributed homogeneously within the matrix. In the present study the laboratory scale discontinuous ultrasonic dispersion process was scaled up to a continuous ultrasonic dispersion process of agglomerated nanoparticles in epoxy resin (EP). Exemplarily, the dispersion experiments were carried out for a 4‐l suspension volume consisting of epoxy resin and 14 vol% TiO2‐nanoparticles was carried out as a function of the dispersion time and the amplitude of the ultrasonic cell. Following, nanocomposites were manufactured with particle contents of 2, 5, and 10 vol%. For the verification of the manufactured nanocomposites quality, particle sizes analysis and mechanical characterization were undertaken. The obtained results were compared with those of the discontinuous dispersion at laboratory scale. It has been found that comparable particle sizes and mechanical properties could be achieved, although, the volume of the suspension was 10 times higher as that one of the batchwise dispersion. POLYM. ENG. SCI., 2012. © 2011 Society of Plastics Engineers
Influence of the sorption of polar and non‐polar solvents on the glass transition temperature of polyamide 6,6 amorphous phase
Authors: De Anda A. Rios , Fillot L.A. , Rossi S. , Long D. , Sotta P. 
Published: August 2011

AbstractThe effect of a series of polar, amphiphilic, and non‐polar solvents of various molecular weights on the glass transition (Tg) of polyamide 6,6 (PA66) amorphous phase was studied. The sorption at equilibrium was measured by immersing the polymer in each solvent. Differential scanning calorimetry (DSC) and broadband dielectric spectroscopy (BDS) were used to characterize the Tg of solvent‐saturated samples. It was observed that the solvent sorption provokes a drop on the polymer Tg, depending on the interactions between the polymer and the solvents. Polar molecules are absorbed in large amounts and decrease the Tg by more than 80°C, whereas non‐polar molecules are absorbed in very small quantities but have a large effect on Tg as well. The sorption equilibrium and Tg shift in the presence of the E10 mixture (10%vol ethanol, 45%vol toluene, and 45%vol isooctane) were also analyzed. A large E10 intake and a Tg drop close to that with pure ethanol are observed. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers
Morphology development of EPDM/PP uncross‐linked/dynamically cross‐linked blends
Authors: Shahbikian S. , Carreau P.J. , Heuzey M.‐C. , Ellul M.D. , Cheng J. , Shirodkar P. , Nadella H.P. 
Published: August 2011

AbstractEthylene‐propylene‐diene‐terpolymer (EPDM) and polypropylene (PP)‐based uncross‐linked and dynamically cross‐linked blends were prepared both in an internal mixer and in a corotating twin‐screw extruder. The effects of composition, plasticization and mixing equipment on the morphology development and the final viscoelastic properties were studied. In the uncross‐linked blends, the plasticization resulted in a coarser morphology. Furthermore, it was shown that the majority of the plasticizer resided in the EPDM phase, enabling its deformation in the flow direction. In addition, the intensive mixing conditions inside the twin‐screw extruder resulted in a finer morphology. In the dynamically cross‐linked blends, the twin‐screw extrusion process resulted in a higher level of gel content with larger EPDM domains. The plasticization showed again a coarsening effect, resulting in interconnected cross‐linked EPDM domains. An interesting interfacial phenomenon was observed especially in the plasticized vulcanized blends where nanometer size occluded PP domains were stripped off and eroded into the EPDM phase. With the exception of the nonplasticized uncross‐linked blends, the viscoelastic properties of all other blending systems were found to be directly affected by the morphology, gel content (in the case of cross‐linked blends), and the presence of the plasticizer. POLYM. ENG. SCI., 2012. © 2011 Society of Plastics Engineers
Crosslinked polyamide based on main‐chain type polybenzoxazines derived from a primary amine‐functionalized benzoxazine monomer
Authors: Agag Tarek , Arza Carlos R. , Maurer Frans H. J. , Ishida Hatsuo 
Published: August 2011

AbstractTwo types of main‐chain type polybenzoxazines with amide and benzoxazine groups as repeating units in the main chain, termed as poly(amide‐benzoxazine), have been synthesized. They have been prepared by polycondensation reaction of primary amine‐bifunctional benzoxazine with adipoyl and isophthaloyl dichloride using dimethylacetamide as solvent. Additionally, a model reaction is designed from the reaction of 3,3′‐(4,4′‐methylenebis(4,1‐phenylene))bis(3,4‐dihydro‐2H‐benzo[e][1,3]oxazin‐6‐amine) with benzoyl chloride. The structures of model compound and polyamides are confirmed by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR) spectroscopies. Differential scanning calorimetry and FTIR are also used to study crosslinking behavior of both the model compound and polymers. Thermal properties of the crosslinked polymers are also studied by thermogravimetric analysis. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Nonisothermal crystallization kinetics of in situ nylon 6/graphene composites by differential scanning calorimetry
Authors: Zhang Fan , Peng Xiaochun , Yan Wenbin , Peng Zhiyuan , Shen Yongqiang 
Published: August 2011

AbstractThe nonisothermal crystallization kinetics was investigated by differential scanning calorimetry for the nylon 6/graphene composites prepared by in situ polymerization. The Avrami theory modified by Jeziorny, Ozawa equation, and Mo equation was used to describe the nonisothermal crystallization kinetics. The analysis based on the Avrami theory modified by Jeziorny shows that, at lower cooling rates (at 5, 10, and 20 K/min), the nylon 6/graphene composites have lower crystallization rate than pure nylon 6. However, at higher cooling rates (at 40 K/min), the nylon 6/graphene composites have higher crystallization rate than pure nylon 6. The values of Avrami exponent m and the cooling crystallization function F(T) from Ozawa plots indicate that the mode of the nucleation and growth at initial stage of the nonisothermal crystallization may be as follows: two‐dimensional (2D), then one‐dimensional (1D) for all samples at 5–10 °C/min; three‐dimensional (3D) or complicated than 3D, then 2D and 1D at 10–20 and 20–40 °C/min. The good linearity of the Mo plots indicated that the combined approach could successfully describe the crystallization processes of the nylon 6 and nylon 6/graphene composites. The activation energies (ΔE) of the nylon 6/graphene composites, determined by Kissinger method, were lower than those of pure nylon 6. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 49: 1381–1388, 2011
Crystallization and stereocomplexation behavior of poly(D‐ and L‐lactide)‐b‐poly(N,N‐dimethylamino‐2‐ethyl methacrylate) block copolymers
Authors: Michell Rose Mary , Müller Alejandro J. , Spasova Mariya , Dubois Philippe , Burattini Stefano , Greenland Barnaby W. , Hamley Ian W. , Hermida‐Merino Daniel , Cheval Nicolas , Fahmi Amir 
Published: August 2011

AbstractThe thermal properties, crystallization, and morphology of amphiphilic poly(D‐lactide)‐b‐poly(N,N‐dimethylamino‐2‐ethyl methacrylate) (PDLA‐b‐PDMAEMA) and poly (L‐lactide)‐b‐poly(N,N‐dimethylamino‐2‐ethyl methacrylate) (PLLA‐b‐PDMAEMA) copolymers were studied and compared to those of the corresponding poly(lactide) homopolymers. Additionally, stereocomplexation of these copolymers was studied. The crystallization kinetics of the PLA blocks was retarded by the presence of the PDMAEMA block. The studied copolymers were found to be miscible in the melt and the glassy state. The Avrami theory was able to predict the entire crystallization range of the PLA isothermal overall crystallization. The melting points of PLDA/PLLA and PLA/PLA‐b‐PDMAEMA stereocomplexes were higher than those formed by copolymer mixtures. This indicates that the PDMAEMA block is influencing the stability of the stereocomplex structures. For the low molecular weight samples, the stereocomplexes particles exhibited a conventional disk‐shape structure and, for high molecular weight samples, the particles displayed unusual star‐like shape morphology. © 2011 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 49: 1397–1409, 2011
Anxiety and specific distress in women at intermediate and high risk of breast cancer before and after surveillance by magnetic resonance imaging and mammography versus standard mammography
Authors: Brédart Anne , Kop Jean‐Luc , Fall Mouhamadou , Pelissier Sandra , Simondi Cécile , Dolbeault Sylvie , Livartowski Alain , Tardivon Anne ,   for the Magnetic Resonance Imaging study group (STIC IRM 2005)
Published: August 2011

AbstractBackgroundIntensive surveillance in women at intermediate and high breast cancer risk is currently investigated in a French prospective, non‐randomized, multicentre study. Two surveillance modalities, standard imaging—mammography ± ultrasound (‘Mx’)—or standard imaging with magnetic resonance imaging (‘MRI’), provided according to the level of breast cancer risk, are compared on psychological distress.MethodsA total of 1561 women were invited to complete the State–Trait Anxiety Inventory (STAI), Impact of Event Scale (IES) Intrusion and Avoidance subscales and breast cancer‐risk perception items at T0 (before examination) and T2 (1 to 3 months later) and the STAI‐State anxiety at T1 (just after examination). Multiple regression analyses were performed.ResultsBaseline compliance was high (>91%). Between surveillance modalities, women differed significantly for age, education level, breast cancer‐risk objective estimates and subjective perception. Mean STAI‐State anxiety scores reflected low to moderate distress in both surveillance modalities. At baseline, MRI was associated with lower STAI‐State anxiety (p ≤ 0.001) and Avoidance scores (p = 0.02), but at T1 and T2, no difference between surveillance modalities was observed on psychological outcomes. Abnormal surveillance result was associated with a higher STAI‐State anxiety (p ≤ 0.01) and IES‐Intrusion (p ≤ 0.01) scores; a personal history of breast cancer and higher risk perception was associated with higher psychological distress at T1 and T2.ConclusionStandard breast imaging including MRI does not seem to convey more harmful psychological effects than standard imaging alone. Higher psychological distress observed in the case of history of breast cancer or higher breast cancer‐risk perception evidences women with needs for specific support and information. Copyright © 2011 John Wiley & Sons, Ltd.