bluuebunny/crossref_metadata_2025_split huggingface dataset:
A phase 1 study of everolimus and sorafenib for metastatic clear cell renal cell carcinoma
Authors: Harzstark Andrea L. , Small Eric J. , Weinberg Vivian K. , Sun Janine , Ryan Charles J. , Lin Amy M. , Fong Lawrence , Brocks Dion R. , Rosenberg Jonathan E. 
Published: March 2011

AbstractBACKGROUND:The current study was conducted to assess the maximum tolerated dose (MTD), safety, pharmacokinetics, and preliminary antitumor effect of everolimus, a mammalian target of rapamycin inhibitor, in combination with sorafenib, a tyrosine kinase inhibitor, in patients with metastatic clear cell renal cell carcinoma.METHODS:Sequential cohorts of patients received escalating doses of everolimus and sorafenib in 28‐day cycles in the absence of a dose‐limiting toxicity (DLT) or disease progression were examined.RESULTS:Twenty patients with a median age of 65 years received therapy in 3 cohorts. Dose level 1 was comprised of everolimus at a dose of 2.5 mg daily and sorafenib at a dose of 400 mg twice daily (6 patients), dose level 2 was comprised of everolimus at a dose of 5 mg daily and sorafenib at a dose of 400 mg twice daily (8 patients), and dose level 3 was comprised of everolimus at a dose of 10 mg daily and sorafenib at a dose of 200 mg twice daily (6 patients). DLTs included grade 4 (according to National Cancer Institute Common Terminology Criteria for Adverse Events [version 3.0]) hyperuricemia with grade 2 gout and grade 3 lipase associated with grade 2 pancreatitis at dose level 2, and grade 3 rash in 2 patients at dose level 3. Dose level 2 (everolimus at a dose of 5 mg daily and sorafenib at a dose of 400 mg twice daily) was established as the maximum tolerated dose. Treatment‐related adverse events occurring in >20% of patients included diarrhea, hand‐foot syndrome, hypertension, hypophosphatemia, hypothyroidism, and rash. Five of 20 patients achieved Response Evaluation Criteria In Solid Tumors (RECIST)‐defined partial responses, all of which occurred in patients without a history of prior systemic therapy. Seven of 8 patients treated at dose level 2 experienced a partial response or stable disease. Pharmacokinetic analysis revealed no interaction between everolimus and sorafenib.CONCLUSIONS:The combination of everolimus and sorafenib was associated with acceptable toxicity and evidence of antitumor activity in previously untreated patients with metastatic renal cell carcinoma. Cancer 2011;. © 2011 American Cancer Society.
Impact of body mass index on clinical outcomes in triple‐negative breast cancer
Authors: Ademuyiwa Foluso O. , Groman Adrienne , O'Connor Tracey , Ambrosone Christine , Watroba Nancy , Edge Stephen B. 
Published: March 2011

AbstractBACKGROUND:Obesity is associated with poorer outcomes in patients with hormone receptor‐positive breast cancers. This association is not well established for women with triple‐negative breast cancers (TNBC). In this study, the prognostic effects of body mass index on clinical outcome were evaluated in patients with TNBC.METHODS:A retrospective study was conducted on 418 patients who were treated between July 1996 and July 2010 for TNBC. Recurrence‐free survival (RFS) and overall survival (OS) were evaluated in relation to body mass index (BMI) after controlling for clinically significant variables.RESULTS:One hundred twenty‐four patients (29.7%) were normal/underweight (BMI ≤24.9 kg/m2), 130 patients (31.1%) were overweight (BMI from 25 to 29.9 kg/m2), and 164 patients (39.2%) were obese (BMI ≥30 kg/m2). At a median follow‐up of 37.2 months, there were 105 recurrences (25.1%) and 87 deaths (20.8%). Compared with normal/underweight patients, the multivariate hazard ratio (HR) for RFS was 0.81 (95% confidence interval [CI], 0.49‐1.34) for obese patients. Similarly, OS was not associated with BMI category; obese patients had an HR of death of 0.94 (95% CI, 0.54‐1.64) compared with normal/underweight patients. A Cox regression analysis identified the receipt of chemotherapy (HR, 0.25; 95% CI, 0.12‐0.52), ductal histology (HR, 0.49; 95% CI, 0.25‐0.97), stage III disease (HR, 3.5; 95% CI, 1.35‐9.06), and increasing tumor size (HR, 1.19; 95% CI, 1.09‐1.3) as independent prognostic factors for OS.CONCLUSIONS:No significant relation between obesity and RFS or OS emerged in patients with TNBC after controlling for clinically significant factors. Cancer 2011;. © 2011 American Cancer Society.
Does the revised International Federation of Gynecology and Obstetrics staging system for endometrial cancer lead to increased discrimination in patient outcomes?
Authors: Cooke Ellen W. , Pappas Lisa , Gaffney David K. 
Published: March 2011

AbstractBACKGROUND:Recent changes were made to the International Federation of Gynecology and Obstetrics (FIGO) staging system for endometrial cancer. The objective of this study was to compare survival outcomes for patients who were staged according to the 1988 FIGO staging system versus the 2009 FIGO staging system.METHODS:Data were obtained from the Surveillance, Epidemiology, and End Results Program for the years 1998 to 2006. Patients who had a diagnosis of adenocarcinoma of the uterus with complete staging information were included. Patients were staged according to the 1988 and 2009 FIGO staging systems, and Kaplan‐Meier estimates were derived for cause‐specific survival (CSS). Univariate and multivariate analyses using Cox proportional hazards models were used to identify the factors associated with survival.RESULTS:In total, 47,284 patients were included. The median follow‐up was 37 months. The 5‐year CSS rates for patients who had 2009 FIGO stage IA and IB disease were 96.6% and 89.9%, respectively (P < .0001). After accounting for age, grade, and race, this survival difference remained significant (hazard ratio [HR], 1.97; 95% confidence interval [CI], 1.74‐2.24; P < .0001). Patients who had 1988 FIGO stage IIA disease had a 5‐year CSS rate similar to that of patients who had 1988 FIGO stage IC disease (88.6% vs 89.9%, respectively; P = .09). Patients who had positive pelvic washings had a 5‐year CSS rate similar to that of patients who had stage IIIA disease according to the 2009 FIGO system (74.2% vs 72.1%, respectively; P = .37). The 5‐year CSS rate for patients who had stage IIIC1 disease was significantly improved compared with that for patients who had stage IIIC2 disease (68.2% vs 57.3%, respectively; P < .0001). In the multivariate model, the survival difference remained (HR, 1.49; 95% CI, 1.26‐1.76; P < .0001).CONCLUSIONS:The 2009 staging system for endometrial cancer produced better discrimination in CSS outcomes compared with the 1988 system. Cancer 2011;. © 2011 American Cancer Society.
Print quality evaluation and applied colour management in coldset offset newspaper print
Authors: Nussbaum Peter , Hardeberg Jon Y. 
Published: March 2011

AbstractThis article aims to investigate print quality in newspaper print, by considering the appropriate calibration standard and applying colour management. In particular, this article examines the colorimetric properties of eight Norwegian newspaper printing presses, to evaluate the relevant colour separation approach, either by applying custom separation profiles or by using an industry standard profile. The key method underlying the work described here relies on obtaining colour measurements to determine the repeatability of each participant in terms of colour differences. Furthermore, the variation between the eight newspaper printing presses and the variation according to the colorimetric values of the ISO 12647‐3 standard are important parts of the quantitative evaluation. Based on the colour measurements two custom ICC profiles were generated and an industry standard profile “ISOnewspaper26v4.icc” was also used. The first custom profile was generated using averaged colour measurement data set from a test print run, and the second using a data set averaged between measured data and the characterization data set “IFRA26.txt” provided by IFRA. These three profiles were applied to four test images, which were then printed by the eight newspaper printing presses. A psychophysical experiment was carried out to determine the “pleasantness” of the reproductions, which were produced using the three profiles. The results of the study show the performance of the appropriate profile, which is applied to the eight newspaper printing presses to obtain significant best print quality. Eventually the results demonstrate the fact that the print variations in colours between the eight printing presses are larger thanthe difference between the custom and the standard profiles. Hence, the print variations and not the profile selection may have determined the visual print quality. Therefore the study reveals the importance of adopting international standards and methods instead of using insufficiently defined house standards to preserve equal results among different newspaper printing presses. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2011
Dual‐reader wireless protocols for dense active RFID identification
Authors: Sun Qunying , Zhang Hongjian , Mo Lingfei 
Published: March 2011

AbstractRadio Frequency Identification (RFID) becomes increasingly widespread in various applications. However, data collision is one of the most concerns in dense active RFID systems. Data collision will cause serious data loss, slow identification speed and high energy consumption. In this paper, data collision problem is addressed and two communication protocols are presented based on the dual‐reader structure. One is the master–slave dual‐reader (MSDR) protocol, and the other is called the dual‐reader DCMA (DRDCMA) protocol. Both protocols are implemented in the hardware platform and their performances are compared with other conventional anti‐collision protocols. Experimental results show that our proposed protocols outperform the conventional ones in terms of identification rate, identification speed and energy consumption. Compared to the Single‐reader (SR) protocol, the proposed MSDR protocol can improve the identification rate by 82.9%, reduce the access latency and energy consumption by 47.0%. Besides, the proposed DRDCMA protocol can reduce the access latency and energy consumption by 69.1 and 78.3%, respectively, in comparison with DCMA. Moreover, MSDR has the fastest identification speed and it can improve nearly 100% over SR when the communication load is large enough. DRDCMA presents the highest identification rate with nearly no data loss, while the identification rate in MSDR is 40.6% and decreases dramatically with the increment in communication load. Copyright © 2011 John Wiley & Sons, Ltd.
A new allele of Lyl1 confirms its important role in hematopoietic stem cell function
Authors: Souroullas George P. , Goodell Margaret A. 
Published: March 2011

AbstractLyl1 codes for a bHLH protein that is an important regulator of hematopoietic stem cell function. An existing mutant allele of Lyl1 features a lacZ gene inserted in‐frame into the fourth exon, leaving behind the N‐terminus and the DNA‐binding basic region, resulting in a translated chimeric protein. Here, we have generated a null allele, which allowed us to examine residual function of the N‐terminus in the absence of a bHLH region. The new Lyl1‐/‐ mouse model exhibited a reduced ability to generate lymphoid lineages and a somewhat more severe hematopoietic repopulation defect when transplanting purified hematopoietic stem cells. Our data show that in the absence of the HLH but presence of the N‐terminus, residual function of the Lyl1 is detectable but relatively minor. The new model may be of use for studies of Lyl1 in which a null allele is required, or for which presence of the LacZ may complicate the combined use of additional mouse models bearing the lacZ marker. genesis 49:441–448, 2011. © 2011 Wiley‐Liss, Inc.
Commentary on ‘Interventions for bone disease in children with chronic kidney disease’
Authors: Shroff Rukshana , Rees Lesley 
Published: March 2011

AbstractThis is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Geary DF, Hodson EM, Craig JC. Interventions for bone disease in children with chronic kidney disease. Cochrane Database of Systematic Reviews 2010, Issue 1. Art. No.: CD008327. DOI: 10.1002/14651858.CD008327.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Commentary on “Vaccines for preventing rotavirus diarrhoea: vaccines in use”
Authors: Sahni Leila C. , Boom Julie A. 
Published: March 2011

AbstractThis is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Soares‐Weiser K, MacLehose H, Ben‐Aharon I, Goldberg E, Pitan F, Cunliffe N. Vaccines for preventing rotavirus diarrhoea: vaccines in use. Cochrane Database of Systematic Reviews 2010, Issue 5. Art. No.: CD008521. DOI: 10.1002/14651858.CD008521.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Commentary on ‘Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children’
Authors: Lennon Diana , Al Tamimi Saleh A. 
Published: March 2011

AbstractThese are commentaries on a Cochrane review, published in this issue of EBCH, first published as: Altamimi S, Khalil A, Khalaiwi KA, Milner RA, Pusic MV, Al Othman MA. Short versus standard duration antibiotic therapy for acute streptococcal pharyngitis in children. Cochrane Database of Systematic Reviews 2009, Issue 1. Art. No.: CD004872. DOI: 10.1002/14651858.CD004872.pub2.Further information for this Cochrane review is available in this issue of EBCH in the accompanying Summary article. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
The Coughing Baby
Authors: Thomas Mike 
Published: March 2011

AbstractThis Dr Cochrane clinical vignette is based upon an overview of Cochrane Reviews that was published in the previous issue of Evidence‐Based Child Health: Bialy L, Foisy M, Smith M and Fernandes RM: The Cochrane Library and the Treatment of Bronchiolitis in Children: An Overview of Reviews. Evid‐Based Child Health 2011, 6: 258–275.Dr Cochrane is a unique self‐learning experience—the integration of Cochrane evidence with a quirky fictional story and multiple‐choice questions provides readers with the opportunity to explore and understand the applicability of a Cochrane Review or Overview in a new way.In this series of fictional clinical vignettes, Dr Cochrane travels across time from the past century to the present day, to solve clinical problems using evidence from Cochrane Reviews. Read the associated article and then test your knowledge with five multiple choice questions. You can find the answers to the questions on page 806. Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Aroma perception in dairy products: the roles of texture, aroma release and consumer physiology. A review.
Authors: Gierczynski Isabelle , Guichard Elisabeth , Laboure Helene 
Published: March 2011

AbstractAroma perception is a determinant factor in food choices and acceptability by consumers. To be perceived, aroma compounds must be released in the mouth during food breakdown, transferred into the nasal cavity to reach the olfactory receptor and then be perceived. So, in order to control aroma perception, knowledge of the main factors that can influence in‐mouth aroma release is of major importance. Focusing on dairy products, this review article investigates the factors due to: (i) food products, and mainly the influence of food composition and structure on aroma retention and release; (ii) the inter‐individual variability of subjects, mainly chewing behaviour, saliva rate and composition and their influence on aroma release; and (iii) the interactions between food products and subjects and their impact on aroma release and perception. We also discuss the various instrumental and sensory methodologies that are often used to study aroma–texture interactions in dairy products, with particular focus on articles that compare in vivo aroma release and perception in dairy products. This review emphasizes that the relationship existing between in vivo aroma release and perception in dairy products is strongly dependent on the type of texture relative to two mechanisms; physicochemical mechanisms based on the modification of aroma release and a cognitive mechanism based on aroma–taste–texture interactions. These two mechanisms exist simultaneously but have more or less impact on aroma perception, depending on the type of texture. Copyright © 2011 John Wiley & Sons, Ltd.
A method for estimating soil moisture storage in regions under water stress and storage depletion: a case study of Hai River Basin, North China
Authors: Moiwo Juana Paul , Yang Yonghui , Han Shumin , Lu Wenxi , Yan Nana , Wu Bingfang 
Published: March 2011

AbstractSoil moisture is a consideration for soil conservation, agricultural production and climate modelling. This article presents a simple method for estimating soil moisture storage under water stress and storage depletion conditions. The method is driven by the common agro‐hydrologic variables of precipitation (PPT), irrigation (IRR) and evapotranspiration (ET). The proposed method is successfully tested for the 152 000 km2 floodplain region of Hai River Basin using 48 consecutive months (2003–2006) of data. Soil moisture data from global land data assimilation system/Noah land surface model are validated with ground‐truth data from 102 soil moisture monitoring sites. The validated soil moisture is used in combination with in situ groundwater data to quantify total water storage change (TWSC) in the region. The estimated storage change is in turn compared with gravity recovery and climate experiment‐derived TWSC for the study area. The soil moisture and TWSC terms show favourable agreements, with discrepancies of < 10% on the average. While there is no consistent seasonal trend in soil moisture, TWSC shows a strong seasonality. It is low in spring and high in summer. This trend corresponds with the IRR–PPT season in the study area. Change in groundwater and total water storage indicates storage depletion in the basin. Storage depletion in the region is driven mainly by groundwater IRR and ET loss. Despite the low PPT and high ET, there is narrowing seasonal trend in soil moisture. This is achieved at the expense of groundwater storage. IRR pumping has induced extensive groundwater depletion in the basin. It is therefore vital to develop cultivation strategies that aim at limiting IRR pumping and ET loss. Water management practices that not only reduce waste but also ensure high productivity and ecological sustainability could also mitigate storage depletion in the region. These measures could reduce further not only the seasonal trend in soil moisture but also that in groundwater storage. Copyright © 2011 John Wiley & Sons, Ltd.
A coupled model for simulating surface water and groundwater interactions in coastal wetlands
Authors: Yuan Li‐Rong , Xin Pei , Kong Jun , Li Ling , Lockington David 
Published: March 2011

AbstractCoastal wetlands are characterized by strong, dynamic interactions between surface water and groundwater. This paper presents a coupled model that simulates interacting surface water and groundwater flow and solute transport processes in these wetlands. The coupled model is based on two existing (sub) models for surface water and groundwater, respectively: ELCIRC (a three‐dimensional (3‐D) finite‐volume/finite‐difference model for simulating shallow water flow and solute transport in rivers, estuaries and coastal seas) and SUTRA (a 3‐D finite‐element/finite‐difference model for simulating variably saturated, variable‐density fluid flow and solute transport in porous media). Both submodels, using compatible unstructured meshes, are coupled spatially at the common interface between the surface water and groundwater bodies. The surface water level and solute concentrations computed by the ELCIRC model are used to determine the boundary conditions of the SUTRA‐based groundwater model at the interface. In turn, the groundwater model provides water and solute fluxes as inputs for the continuity equations of surface water flow and solute transport to account for the mass exchange across the interface. Additionally, flux from the seepage face was routed instantaneously to the nearest surface water cell according to the local sediment surface slope. With an external coupling approach, these two submodels run in parallel using time steps of different sizes. The time step (Δtg) for the groundwater model is set to be larger than that (Δts) used by the surface water model for computational efficiency: Δtg = M × Δts where M is an integer greater than 1. Data exchange takes place between the two submodels through a common database at synchronized times (e.g. end of each Δtg). The coupled model was validated against two previously reported experiments on surface water and groundwater interactions in coastal lagoons. The results suggest that the model represents well the interacting surface water and groundwater flow and solute transport processes in the lagoons. Copyright © 2011 John Wiley & Sons, Ltd.
Evaluation of cervical cone biopsies for coexpression of p16INK4a and Ki‐67 in epithelial cells
Authors: Reuschenbach Miriam , Seiz Mirjam , Doeberitz Christina von Knebel , Vinokurova Svetlana , Duwe Alexander , Ridder Ruediger , Sartor Heike , Kommoss Friedrich , Schmidt Dietmar , Doeberitz Magnus von Knebel 
Published: March 2011

AbstractDiffuse overexpression of p16INK4a in basal and parabasal cells of cervical epithelium is a hallmark of human papillomavirus‐mediated transformation. Focal p16INK4a expression is occasionally observed in nondysplastic epithelium. In normal cells, expression of p16INK4a triggers cell cycle arrest. However, cells undergoing transformation in intraepithelial lesions actively proliferate. To prove that the different expression patterns of p16INK4a, i.e., focal versus diffuse, reflect biologically different entities, we hypothesized that p16INK4a‐positive cells in epithelia displaying focal p16INK4a expression pattern do not coexpress proliferation‐associated Ki‐67 protein, while p16INK4a‐positive cells in lesions with diffuse p16INK4a expression may do. A total of 138 cervical cone biopsies were stained for the expression of p16INK4a and Ki‐67 using a primary antibody cocktail. All metaplastic lesions (n = 21) displayed focal staining for p16INK4a, and in all of these lesions p16INK4a‐positive cells were found to be negative for Ki‐67 expression. Diffuse expression of p16INK4a was observed in 12/21 (57.1%) cervical intraepithelial neoplasia (CIN) 1 lesions, all of them simultaneously showed Ki‐67 immunoreactivity in a large proportion of p16INK4a‐positive cells. Seventeen of 23 (73.9%) CIN2 lesions and all 27 (100%) CIN3/carcinoma in situ (CIS) as well as all 46 (100%) carcinoma cases displayed diffuse and combined expression of p16INK4a and Ki‐67. Coexpression of Ki‐67 and p16INK4a in the same cell is entirely restricted to cervical lesions displaying diffuse p16INK4a expression, whereas in lesions with focal p16INK4a expression, p16INK4a‐expressing cells are negative for Ki‐67. Thus, diffuse expression of p16INK4a reflects lesions with proliferation‐competent cells, while p16INK4a‐expressing cells associated with focal expression patterns are cell cycle arrested.