bluuebunny/crossref_metadata_2025_split huggingface dataset:
A quantum sensing metrology for magnetic memories
Authors: Borràs Vicent J. , Carpenter Robert , Žaper Liza , Rao Siddharth , Couet Sebastien , Munsch Mathieu , Maletinsky Patrick , Rickhaus Peter 
Published: June 2024

AbstractMagnetic random access memory (MRAM) is a leading emergent memory technology that is poised to replace current non-volatile memory technologies such as eFlash. However, controlling and improving distributions of device properties becomes a key enabler of new applications at this stage of technology development. Here, we introduce a non-contact metrology technique deploying scanning NV magnetometry (SNVM) to investigate MRAM performance at the individual bit level. We demonstrate magnetic reversal characterization in individual, <60 nm-sized bits, to extract key magnetic properties, thermal stability, and switching statistics, and thereby gauge bit-to-bit uniformity. We showcase the performance of our method by benchmarking two distinct bit etching processes immediately after pattern formation. In contrast to ensemble averaging methods such as perpendicular magneto-optical Kerr effect, we show that it is possible to identify out of distribution (tail-bits) bits that seem associated to the edges of the array, enabling failure analysis of tail bits. Our findings highlight the potential of nanoscale quantum sensing of MRAM devices for early-stage screening in the processing line, paving the way for future incorporation of this nanoscale characterization tool in the semiconductor industry.
Perspective: There is plenty of room for magnetic straintronics in the analog domain
Authors: Bandyopadhyay Supriyo 
Published: June 2024

AbstractMagnetic straintronics made its debut more than a decade ago as an extremely energy-efficient paradigm for implementing a digital switch for digital information processing. The switch consists of a slightly elliptical nano-sized magnetostrictive disk in elastic contact with a poled ultrathin piezoelectric layer (forming a two-phase multiferroic system). Because of the elliptical shape, the nanomagnet’s magnetization has two stable (mutually antiparallel) orientations along the major axis, which can encode the binary bits 0 and 1. A voltage pulse of sub-ns duration and amplitude few to few tens of mV applied across the piezoelectric generates enough strain in the nanomagnet to switch its magnetization from one stable state to the other by virtue of the inverse magnetostriction (or Villari) effect, with an energy expenditure that is roughly an order of magnitude smaller than what it takes to switch a modern-day electronic transistor. That possibility, along with the fact that such a switch is non-volatile unlike the conventional transistor, generated significant excitement. However, it was later tempered by the realization that straintronic switching is also extremely error-prone, which may preclude many digital applications, particularly in Boolean logic. In this perspective, we offer the view that there is plenty of room for magnetic straintronics in the analog domain, which is much more forgiving of switching errors, and where the excellent energy-efficiency and non-volatility are a boon. Analog straintronics can have intriguing applications in many areas, such as a new genre of aggressively miniaturized electromagnetic antennas that defy the Harrington limits on the gain and radiation efficiency of conventional antennas, analog arithmetic multipliers (and ultimately vector matrix multipliers) for non-volatile deep learning networks with very small footprint and excellent energy-efficiency, and relatively high-power microwave oscillators with output frequency in the X-band. When combined with spintronics, analog straintronics can also implement a new type of spin field effect transistor employing quantum materials such as topological insulators, and they have unusual transfer characteristics which can be exploited for analog tasks such as frequency multiplication using just a single transistor. All this hints at a world of new possibilities in the analog domain that deserves serious attention.
Low-coherence semiconductor light sources: devices and applications
Authors: Lu Hang , Alkhazragi Omar , Wang Yue , Almaymoni Nawal , Yan Wenbo , Gunawan Wahyu Hendra , Lin Heming , Park Tae-Yong , Ng Tien Khee , Ooi Boon S. 
Published: June 2024

AbstractSince the invention of the laser, there have been countless applications that were made possible or improved through exploiting its multitude of unique advantages. Most of these advantages are mainly due to the high degree of coherence of the laser light, which makes it directional and spectrally pure. Nevertheless, many fields require a moderate degree of temporal or spatial coherence, making conventional lasers unsuitable for these applications. This has brought about a great interest in partially coherent light sources, especially those based on semiconductor devices, given their efficiency, compactness, and high-speed operation. Here, we review the development of low-coherence semiconductor light sources, including superluminescent diodes, highly multimode lasers, and random lasers, and the wide range of applications in which they have been deployed. We highlight how each of these applications benefsits from a lower degree of coherence in space and/or time. We then discuss future potential applications that can be enabled using new types of low-coherence light.
Power-modulated reconfigurable nonlinear plasmonic devices without DC power supply and feed circuit
Authors: Cui Wen Yi , Gao Xinxin , Zhang Jingjing , Luo Yu , Cui Tie Jun 
Published: June 2024

AbstractHigh-power electromagnetic (EM) waves can directly modulate the parameters of nonlinear varactor diodes through the rectification and Kerr effects without relying on external sources. Based on this principle, we propose a power-modulated reconfigurable nonlinear device based on spoof surface plasmon polariton (SSPP) waveguide loaded by varactor diodes, without applying DC power supply or feed circuit. Increasing the input power level reduces the effective capacitance of the varactor diode, leading to a blueshift in the cutoff frequency of the SSPP waveguide. This feature can be employed to realize the switching on/off of the input signal depending on the signal power. On the other hand, the transmission state of a low-power signal can be controlled by inputting another independent high-power EM wave simultaneously. Increasing the power of the control wave will enable the low-power signal within a wider bandwidth switched from off to on states. Experimental results are presented to show the excellent performance of the power-modulated reconfigurable SSPP device. This method can reduce the system complexity and provide inspiration for reconfigurable all-passive multifunctional devices and systems.
A multispectral 3D live organoid imaging platform to screen probes for fluorescence guided surgery
Authors: Jeremiasse Bernadette , van Ineveld Ravian L , Bok Veerle , Kleinnijenhuis Michiel , de Blank Sam , Alieva Maria , Johnson Hannah R , van Vliet Esmée J , Zeeman Amber L , Wellens Lianne M , Llibre-Palomar Gerard , Barrera Román Mario , Di Maggio Alessia , Dekkers Johanna F , Oliveira Sabrina , Vahrmeijer Alexander L , Molenaar Jan J , Wijnen Marc HWA , van der Steeg Alida FW , Wehrens Ellen J , Rios Anne C 
Published: June 2024

AbstractAchieving complete tumor resection is challenging and can be improved by real-time fluorescence-guided surgery with molecular-targeted probes. However, pre-clinical identification and validation of probes presents a lengthy process that is traditionally performed in animal models and further hampered by inter- and intra-tumoral heterogeneity in target expression. To screen multiple probes at patient scale, we developed a multispectral real-time 3D imaging platform that implements organoid technology to effectively model patient tumor heterogeneity and, importantly, healthy human tissue binding.
The role of microglia in the development of diabetic retinopathy
Authors: Quiriconi Pialuisa , Hristov Vanco , Aburaya Mayu , Greferath Una , Jobling Andrew I. , Fletcher Erica L. 
Published: June 2024

AbstractDiabetic retinopathy is a vision-threatening disease and remains the most feared complication for those living with diabetes. Historically, the disease has been considered primarily vascular in nature, based on clinically detectable vascular pathology. Nonetheless, it is now recognized that the retina undergoes a variety of cellular changes from the early onset of diabetes. In fact, one of the earliest changes to occur is a loss in vasoregulation, yet our understanding of the underlying mechanisms is lacking. Microglia, the resident immune cells of the central nervous system, perform a range of physiological, non-inflammatory functions to maintain retinal homeostasis which includes surveying the microenvironment to constantly monitor tissue health, neuronal surveillance to maintain synaptic integrity and vasoregulation, a recently discovered role that these cells additionally perform. The role of microglia in the development of diabetic retinopathy is well-established, centered around their contribution to inflammation which remains an integral component in disease pathogenesis, particularly in later stages of disease. However, recent findings reveal that early in the development of diabetes the vasoregulatory function of microglia is dysfunctional, leading to early vascular compromise. This review summarizes recent work to highlight how microglia are affected by diabetes and the implications of these changes in the development of diabetic retinopathy from pre-clinical to advanced stages of disease.
Gut microbiota metabolism disturbance is associated with postoperative atrial fibrillation after coronary artery bypass grafting
Authors: Liu Yuhua , Du Zhiyong , Lu Yingyuan , Ma Ying , Yang Yunxiao , Osmanaj Florian , Zhang Yifan , Guo Xiaoyu , Qin Yanwen , Yang Xiubin , Hua Kun 
Published: June 2024

AbstractPostoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) surgery. Gut microbiota and its metabolites have been implicated in the development of AF. However, whether the gut–host metabolic interaction contributes to POAF is still unknown. This study aimed to investigate the POAF-associated gut microbiota metabolism biomarkers and related risk model. The POAF (N = 30) patients and non-POAF (N = 60) patients from the discovery cohort exhibited significantly different microbiome and metabolome profiles. The differentiated features were mainly implicated in the bile acids (BAs) and short-chain fatty acids metabolism, inflammation, and oxidative stress. Random forest analysis identified the combination of five secondary BAs showed a powerful performance on predicting POAF in the discovery cohort, highlighting significant values of area under the curve (AUC = 0.954) and correct classification rate (CCR, 93.3%). In addition, the five secondary BAs-based risk model also exhibited good performance in differentiating the POAF (N = 114) and non-POAF individuals (N = 253) in an independent validation cohort (AUC = 0.872; CCR = 90.4%). This work revealed perturbed microbial and metabolic traits in POAF, providing potential avenues for the prediction and prevention of POAF after CABG.
Revisiting the role of cosmic-ray driven Alfvén waves in pre-existing magnetohydrodynamic turbulence
Authors: Sergio Cerri Silvio 
Published: June 2024

Context. Alfvén waves (AWs) excited by the cosmic-ray (CR) streaming instability (CRSI) are a fundamental ingredient for CR confinement. The effectiveness of such self-confinement relies on a balance between the CRSI growth rate and the damping mechanisms acting on quasi-parallel AWs excited by CRs. One relevant mechanism is called turbulent damping, in which an AW packet injected in pre-existing turbulence undergoes a cascade process due to its nonlinear interaction with fluctuations of the background.
Aims. The turbulent damping of an AW packet in pre-existing magnetohydrodynamic (MHD) turbulence is re-examined, revised, and extended to include the most recent theories of MHD turbulence that account for dynamic alignment and reconnection-mediated regimes. The case in which the role of feedback of CR-driven AWs on pre-existing turbulence is important is also discussed.
Methods. The Elsässer formalism is employed. Particular attention is given to the role of a nonlinearity parameter χw that estimates the strength of the nonlinear interaction between CR-driven AW packets and the background fluctuations. We point out the difference between χw and the parameter χz that instead describes the intrinsic strength of nonlinear interactions between pre-existing fluctuations. Turbulent damping rates of quasi-parallel AW packets and cosmic-ray feedback (CRF) are derived within this formalism.
Results. When the strength of the nonlinear interaction is properly taken into account, we find that (i) the turbulent damping rate of quasi-parallel AWs in sub-Alfvénic turbulence depends on the background-fluctuation amplitude to the third power, and hence is strongly suppressed; (ii) the dependence on the AW’s wavelength (and thus on the CR gyro-radius from which it is excited) is different from what has been previously obtained; and (iii) when dynamic alignment of cascading fluctuations and the possibility of a reconnection-mediated range is included in the picture, the turbulent damping rate exhibits novel regimes and breaks. Finally, a criterion for CRF is derived and a simple phenomenological model of CR-modified scaling of background fluctuations is provided.
Nodale Metastasierung und Stellenwert der Neck Dissection bei T1/2-Oro- und Hypopharynxkarzinomen
Authors: Deuß Eric , Kürten Cornelius H.L. , Meyer Moritz , Buhr Christoph Raphael , Künzel Julian , Ernst Benjamin , Mattheis Stefan , Lang Stephan , Hussain Timon 
Published: June 2024

Zusammenfassung
Hintergrund Die Indikation zur elektiven Neck Dissection (END) bei Patienten mit T1/2-Plattenepithelkarzinomen des Hypopharynx (HPSCC) und Oropharynx (OPSCC) wird nicht einheitlich gestellt. In der vorliegenden Studie erfolgte daher eine detaillierte Analyse des Metastasierungsverhaltens von HPSCC und OPSCC.
Material und Methoden Es erfolgte eine multizentrische retrospektive Analyse des nodalen Metastasierungsverhaltens und der onkologischen Parameter von 262 chirurgisch therapierten HPSCC- und OPSCC-Patienten. Zudem erfolgte eine systematische Literaturrecherche.
Ergebnisse Bei HPSCC-Patienten lag in 62,1% der Fälle eine Diskrepanz zwischen klinischem und pathologischem N-Status vor, bei OPSCC in 52,4% (p16-) bzw. 43,6% (p16+). Die okkulte Metastasierungsrate in den Primärtumorstadien T1/2 lag dabei bei 38,9% für HPSCC und bei 17,8% (p16-) und 11,1% (p16+) für OPSCC. Bei HPSCC traten in den Stadien cT1/2cN0 in 22,2% der Fälle kontralaterale Metastasen auf; die Rate bei OPSCC lag bei lediglich 9,1% (p16-) bzw. 0% (p16+). Patienten mit p16-positiven OPSCC wiesen ein besseres rezidivfreies und Gesamtüberleben auf als p16-negative OPSCC- und HPSCC-Patienten. Ein direkter Zusammenhang zwischen Patientenüberleben und Ausmaß der chirurgischen Therapie des Halses ließ sich nicht nachweisen.
Schlussfolgerung Patienten mit HPSCC weisen ab Stadium cT1/2cN0 ein hohes Risiko für okkulte Halslymphknotenmetastasen auf, welches die Durchführung einer beidseitigen END rechtfertigt. Bei Patienten mit T1/2cN0-OPSCC manifestieren sich ipsilateral in >20% der Fälle okkulte Metastasen; das Risiko für eine kontralaterale okkulte Metastasierung liegt jedoch bei <10%, sodass bei streng lateralisierten Tumoren ein Verzicht auf die kontralaterale Neck Dissection erwogen werden kann.
His-Tagging: Exploring Precise Chemical Modification of Histidine-Containing Bioactive Peptide Sequences
Authors: Chatterjee Sourav , Paul Bishwajit , Shanker Govindaswamy 
Published: June 2024

AbstractThe modification of biomolecules, particularly peptides, has garnered considerable attention from researchers, effectively serving as a connection between chemistry and biology. The modification of peptides can facilitate, among others, the generation of peptide drugs, antibody–drug conjugates, and probes for molecular imaging. Herein, we have carefully curated reactions and chemical transformations of bioactive peptide sequences equipped with histidine amino acids that are conducive for biological applications. This Account also highlights strategies for the chemical modification of histidine that might capture the imagination of both peptide researchers and synthetic chemists.1	Introduction2	Histidine Modification in Bioactive Peptides and Proteins3	Remote Bioactive Peptides and Protein Modification Adjacent to Histidine4	Conclusions and Future Directions
Comparison of Optic Nerve Sheath Diameter (ONSD) Measurements Obtained from USG Before and After Placement of Ventriculoperitoneal Shunt in Obstructive Hydrocephalus as a Surrogate Marker for Adequacy of Shunt Function: A Prospective Observational Study
Authors: Salih M. S. Mohamed , Sethuramachandran Adinarayanan , Bidkar Prasanna Udupi , Dey Ankita , R. Gopikrishnan , Gunasekaran Adethen , Chandar Vivek 
Published: June 2024

Abstract
Introduction Optic nerve sheath diameter (ONSD) measured using ultrasonography has been widely used as a surrogate marker of elevated intracranial pressure. However, literature is sparse on the correlation between ONSD and ventriculoperitoneal (VP) shunt function, especially in adults with hydrocephalus. Our study was designed to assess the correlation between ONSD measured using ultrasonography before and 12 hours after VP shunt placement and the success of VP shunt placement assessed using computed tomography (CT) of the brain.
Materials and Methods Fifty-one patients between 16 and 60 years of age, with obstructive hydrocephalus scheduled for VP shunt surgery were included in this prospective, observational study. ONSD measurements were obtained from both eyes prior to induction of anesthesia, immediately after the surgery, and at 6, 12, and 24 hours after the surgery. An average of three readings was obtained from each eye. Cerebrospinal fluid (CSF) opening pressure was noted after entry into the lateral ventricle. Noncontrast CT (NCCT) brain was obtained 12 hours after the surgery and was interpreted by the same neurosurgeon for signs of successful VP shunt placement.
Results There was a significant reduction in ONSD in the postoperative period compared to ONSD measured preoperatively. The average ONSD (mean ± standard deviation) measured prior to induction of anesthesia, immediately after the surgery, and at 6, 12, and 24 hours after the surgery was 5.71 ± 0.95, 5.20 ± 0.84, 5.06 ± 0.79, 4.90 ± 0.79, and 4.76 ± 0.75 mm, respectively. The mean CSF opening pressure was 19.6 ± 6.9 mm Hg. Postoperative NCCT brain revealed misplacement of the shunt tip in only one patient.
Conclusion ONSD measured using ultrasonography may be used as a reliable indicator of VP shunt function in adults with obstructive hydrocephalus.
Dynamic Interplay of Age and Protein Malnutrition on the Pharmacokinetic Profile of Acetaminophen in Wistar Rats
Authors: Augustin Varsha , D'Souza Vinitha , J. Madhura R. , Badanthadka Murali , Mamatha B.S. , Vijayanarayana K. 
Published: June 2024

Abstract
Objectives Age and protein malnutrition (PMN) are well-known determinants of drug pharmacokinetics. The combined influence of age and nutrition on the pharmacokinetics of acetaminophen (APAP) remains insufficiently explored; therefore, this study investigates the role of age and PMN on APAP pharmacokinetics.
Materials and Methods Wistar rat weanlings were divided into four groups. Groups ND-5 (n = 6) and ND-18 (n = 6) were fed with normal diet (ND, 18% protein) and groups LPD-5 (n = 6) and LPD-18 (n = 6) were fed with low-protein diet (LPD, 10%) for 5 and 18 months, respectively. Blood samples were collected at different time intervals (0, 0.5, 1, 3, 6, 24, 36, and 48 hours), and plasma was separated and analyzed for APAP using high-performance liquid chromatography. Pharmacokinetic data was analyzed by the noncompartmental model using Phoenix WinNonlin 8.3 software.
Results The pharmacokinetic parameters of APAP were elevated in both LPD groups compared with their age-matched controls. The average area under the curve was increased by approximately 131% (LPD-5) and 17.57% (LPD-18), and the average maximum plasma concentrations (Cmax) was increased by 33.5% (LPD-5) and 26.3% (LPD-18) compared with their respective age-matched controls. The average mean retention time was approximately 114% (LPD-5) and 17.4% (LPD-18) higher than their respective age-matched controls, whereas the clearance rate (Cl/F) and volume distribution (Vz/F) of the drug were significantly lower. Consequently, there was a 68.5% (ND-5) and 4.73% (ND-18) prolongation in the mean half-life of APAP.
Conclusion The altered pharmacokinetics may arise from the intricate interplay of dietary and age influences on physiology, protein binding, and cytochrome P450enzyme activity/expression. However, the exact reason requires further investigation for a better understanding of vulnerable populations.
Endoscopic Evacuation of Acute Subdural Hematomas: A New Selection Criterion
Authors: Sam Jo Ee , Komatsu Fuminari , Yamada Yasuhiro , Tanaka Riki , Sasaki Kento , Tamura Takamitsu , Kato Yoko 
Published: June 2024

Abstract
Introduction Acute subdural hematomas (ASDHs) have a high mortality rate and unfavorable outcomes especially in the elderly population even after surgery is performed. The conventional recommended surgeries by the Brain Trauma Foundation in 2006 were craniotomies or craniectomies for ASDH. As the world population ages, and endoscopic techniques improve, endoscopic surgery should be utilized to improve the outcomes in elderly patients with ASDH.
Materials and Methods This was a single-center retrospective report on our series of six patients that underwent endoscopic ASDH evacuation (EASE). Demographic data, the contralateral global cortical atrophy (GCA) score, evacuation rates, and outcomes were analyzed.
Results All patients' symptoms and Glasgow Coma Scale improved or were similar after EASE with no complications. Good outcome was seen in 4 (66.7%) patients. Patients with poor outcome had initial low Glasgow Coma Scale scores on admission. The higher the contralateral GCA score, the higher the evacuation rate (r = 0.825, p ≤ 0.043). All the patients had a GCA score of ≥7.
Conclusion EASE is at least not inferior to craniotomy for the elderly population in terms of functional outcome for now. Using the contralateral GCA score may help identify suitable patients for this technique instead of just using a cut-off age as a criteria.