bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Significance of a Novel Vasculogenic Mimicry-Based Prognostic Model in Hepatocellular Carcinoma
Authors: Zeng Yifan , Jiang Shuwen , Lou Zhuoqi , Chen Lin , Zhang Yongtao , Pan Liya , Shi Qingmiao , Ruan Bing 
Published: May 2024

Background:
Vasculogenic mimicry, a novel neovascularization pattern of
aggressive tumors, is associated with poor clinical outcomes.

Objective:
The aim of this research was to establish a new model, termed VC score, to
predict the prognosis, Tumor Microenvironment (TME) components, and immunotherapeutic
response in Hepatocellular Carcinoma (HCC).

Methods:
The expression data of the public databases were used to develop the prognostic
model. Consensus clustering was performed to confirm the molecular subtypes with
ideal clustering efficacy. The high- and low-risk groups were stratified utilizing the VC
score. Various methodologies, including survival analysis, single-sample Gene Set Enrichment
Analysis (ssGSEA), Tumor Immune Dysfunction and Exclusion scores
(TIDE), Immunophenoscore (IPS), and nomogram, were utilized for verification of the
model performance and to characterize the immune status of HCC tissues. GSEA was
performed to mine functional pathway information.

Results:
The survival and immune characteristics varied between the three molecular
subtypes. A five-gene signature (TPX2, CDC20, CFHR4, SPP1, and NQO1) was verified
to function as an independent predictive factor for the prognosis of patients with
HCC. The high-risk group exhibited lower Overall Survival (OS) rates and higher mortality
rates in comparison to the low-risk group. Patients in the low-risk group were predicted
to benefit from immune checkpoint inhibitor therapy and exhibit increased sensitivity
to immunotherapy. Enrichment analysis revealed that signaling pathways linked to
the cell cycle and DNA replication processes exhibited enrichment in the high-risk
group.

Conclusions:
The VC score holds the potential to establish individualized treatment
plans and clinical management strategies for patients with HCC.
Curcumin Mitigates Streptozotocin-Induced Genotoxicity In Vivo by Activating P53 Protein and Inhibiting Oxidative Stress and Chromosomal
Aberration
Authors: Saha Alik , Chakrovorty Arnob , Bhattacharjee Banani , Nandi Sisir , Samadder Asmita 
Published: May 2024

Background:
Genotoxins are chemical constituents that damage DNA or chromosomal
architecture, leading to alterations in the genetic level. Streptozotocin, a monofunctional nitrosourea
derivative, is often utilized to induce diabetes mellitus in laboratory animals because
of its detrimental effects on pancreatic cells. The purpose of this work was to investigate possible
protective efficacy against the genotoxic effects of Streptozotocin.

Objective:
This study examines the potentiality of curcumin, a phytoproduct with anti-genotoxic
and anti-diabetic qualities, against streptozotocin-induced chromosomal abnormalities and DNA
damage. The study evaluates the possible protective efficacy of curcumin, exploring a variety of
biochemical and molecular biology techniques in murine models.

objective:
This study investigates the potential of curcumin, a phytoproduct having anti-genotoxic and anti-diabetic qualities, against streptozotocin-induced chromosomal abnormalities and DNA damage. The study evaluates the possible protective effects of curcumin using a variety of biochemical and molecular biology techniques in murine model.

Methods:
The experiment involves a control group, the administration of Streptozotocin (Group
S), and a curcumin-pretreated STZ group (Group SC) in mice. The effects of curcumin on DNA
damage and chromosomal aberrations were investigated by histopathology, immunofluorescence,
evaluation of chromosomal aberrations, detection of Reactive oxygen species, cell viability
analysis, and DNA laddering assay.

Results:
The results demonstrated a significant reduction in DNA damage, chromosomal anomalies,
and a decrease in the expression of the p53 protein in the curcumin-treated animals compared
to that of STZ-treated mice.

Conclusion:
The overall results show that curcumin can reduce chromosomal aberrations and
DNA damage by altering the expression of p53 repair proteins. This suggests that curcumin has
a promising future as a therapeutic agent, especially when it comes to drug-induced toxicity and
the development of novel therapeutics.

other:
NA
Current Developments in the Prevention and Improvement of Intestinal
Disorders: A Mini-Review
Authors: Santa Kazuki , Ohsawa Tomonori 
Published: May 2024

Background:
Recently, the number of patients who manifest intestinal disorders has
increased. Particularly, Irritable Bowel Syndrome (IBS) patients and Inflammatory Bowel Disease
(IBD) patients, which include Ulcerative Colitis (UC) and Crohn’s Disease (CD), are on
the rise, especially in the young generation. Behcet’s disease (an autoimmune disease) and bowel
obstruction are also common intestinal disorders. Furthermore, colorectal cancer, including
colon and rectum cancer and small intestinal cancer, are the typical disorders in the intestine.
Other disorders in the digestive tract are infectious diseases like Helicobacter pylori infection.
Even though symptomatic treatments have been increasing for the treatment of intestinal disorders,
the ways of improving and preventing these diseases are still controversial.

Objective:
The progress of medicine and treatment is rapid. However, recent approaches to the
prevention and improvement of these intestinal disorders are suppressing dysbiosis and preventing
chronic inflammation. This mini-review discusses the hypothesis of whether the improvement
of the diet is a preferable choice for the prevention of these intestinal disorders. Dietary
interventions are beneficial for the prevention and improvement of intestinal disorders since the
first approach to intestinal disorders is dietary intervention. The Mediterranean diet, the diet
from the 5-a-day campaign, and the Japanese diet are well-known healthy dietary strategies. A
healthy diet regimen is not only beneficial for the prevention of intestinal disorders but also a
useful strategy to reduce stress and ameliorate mental illness. In addition, the intake of phytochemicals
is good for keeping healthy gut microbiota and preventing intestinal disorders. Furthermore,
vitamin D3 intake with these phytochemicals works as an adjuvant to improve gut
microbiota and upregulate immune responses. As a result, the decreasing production of TNF-α
ameliorates chronic inflammation and intestinal disorders at an early stage.

Conclusion:
In recent years, prevention of the non-disease condition “ME-BYO” has been a
popular approach for healthy and long living in Japan. This idea prevents the manifestation of
diseases before the onset and is also applicable to intestinal disorders. This mini-review discusses
ways of preventing and ameliorating intestinal disorders.
Research Status and Development Trend of Multi-arm Collaborative
Robots
Authors: Han Lu , Yan Farui , Xie Xuedong , Yang Yongqi , Xie Baocheng 
Published: May 2024

Abstract:
Industrial robots are mainly used in metal forming, automotive, and electrical and electronics
industries. After decades of unremitting efforts, industrial robots have achieved great success.
However, problems such as low safety, weak environmental adaptability, and insufficient humancomputer
interaction ability of industrial robots have greatly limited the application of industrial
robots, and multi-arm collaborative robots came into being in this case. Multi-arm collaborative robots
offer high flexibility and precision. Over the years, the application and development of multiarm
collaborative robots have been paid more and more attention. This paper aims to summarize the
patents related to multi-arm cooperative robots, including their principles, classification, latest progress
and future development, in order to meet the needs of the real world. According to the structural
characteristics of multi-arm collaborative robots and the requirements of multi-arm collaborative
robots application field, the most typical mobile collaborative robots and stationary dual-arm collaborative
robots in multi-arm collaborative robots are summarized. By investigating various patents of
multi-arm collaborative robots the main problems of multi-arm collaborative robots are summarized
and analyzed, such as collisions or conflicts between robotic arms, low power-to-weight ratio, loose
structures, and heavy weight of the robot body. In addition, the development trend of multi-arm collaborative
robots is also discussed. Multi-arm robots have broad prospects and potential in future
applications and development. With the advancement of new technologies, multi-arm collaborative
robots will become more efficient, intelligent, safe, and flexible. More relevant patents are expected
to be invented in the future.
Herbal Medicine Use among Adult Lebanese Patients with Chronic Diseases: A Descriptive Cross-sectional Study
Authors: Assi Mohammad , Fahs Iqbal , Lteif Rebecca , Hallal Zahraa , Hdaib Fadi 
Published: May 2024

Introduction
Herbal products are used for the management of various chronic diseases. This study sought to determine the frequency of herbal medicines use among Lebanese patients diagnosed with chronic diseases, their patterns, underlying causes and perceived efficacy.

Methods
This is a descriptive cross-sectional study that enrolled Lebanese adult patients from the six governorates of Lebanon between February and December 2020. Those who had hypertension, diabetes mellitus, dyslipidemia, chronic constipation, or rheumatoid arthritis were eligible for enrollment.

Results
A total of 300 patients participated in this study. Around 123 participants (41%) reported using herbs. The majority purchased the herbs based on a suggestion (47.2%) from a friend or a family member. The most commonly used herbs were Pimpinella anisum, and Garlic (15.8%) for hypertension, Sage (26.9%) and Stevia (23.1%) for diabetes mellitus, Red Yeast Rice (27%) and Hawthorn (23%) for dyslipidemia, and Senna (43.6%) and Artichoke (25.8%) for chronic constipation, and Curcumin (46.2%) and Allium sativum (30.8%) for rheumatoid arthritis. The majority did not have an idea about the side effects (87.8%), drug-herbal interactions (95.1%), or drug-disease interactions (96.8%) of herbs. Most of the patients (65%) were satisfied with the herbal product use.

Conclusion
The use of herbal medicines is common among adult Lebanese patients diagnosed with hypertension, diabetes, dyslipidemia, arthritis, and constipation. However, herbal products are not risk-free. Hence, further research in this area is warranted.
Analysis of Associated Factors Contributing to Type 2 Diabetes Mellitus in the Coastal Community of Bahari Village, Southeast Sulawesi, Indonesia: A Cross-Sectional Study
Authors: Muhammadong Jumadi , Yuyun Wa , Muriman Laode Yusman , Azis Waode Azfari , Subhan Muhamad 
Published: May 2024

Background
Type 2 diabetes mellitus (T2DM) has become a major lifestyle disease that threatens communities in the world. The lifestyles of undiagnosed T2DM are a major issue in Indonesia.

Objective
This study aims to analyze the contribution of associated factors to T2DM in Bahari Village.

Methods
The study was conducted by cross-sectional study. Respondents included 113 men and 157 women were established through simple randomized sampling from March to May 2023. Data analysis using chi-square and logistic regression at p<0.05 using SPSS 25.

Results
The prevalence of T2DM for women (74.2%), 45-65 years (90.9%), no education (58.7%), overweight (38.2%), heavy drinking sweet tea/coffee (77.5%), never physical activity (87.1%), diabetic father and mother (40.3%), and father’s OR 1.42 (CI 95%:0.73-2.75), significantly associated with T2DM. Gender, age, education, BMI, and occupation simultaneously influence (72.7%), and age partially affects T2DM.

Discussion
Decreased insulin sensitivity and increased risk of developing diabetes can be influenced by various factors, such as genetics, lifestyle, physical activity, and the environment, either partially or simultaneously.

Conclusion
The respondents' advanced age, obesity, lack of education, preference for sweet foods, and inactivity all contributed to their type 2 diabetes. These coastal communities need to make lifestyle changes to reduce the burden of diabetes.

Classification
Epidemiology; Environmental Health; Science of Nutrition MeSH.
Students’ preparation in IELTS Writing Task 1: How to write a summary of visual information
Authors: Fitria Tira Nur 
Published: May 2024

The International English Language Testing System (IELTS) Writing Task 1 is used to test participants' ability to select and report main ideas, describe and compare data, identify trends in factual information, or describe a process. This research describes the types of questions in IELTS Writing Task 1 and how to write a summary of visual information usually in the form of a graph, chart, or diagram in IELTS Writing Task 1. This research uses a descriptive qualitative approach. The analysis shows that IELTS Academic Writing Task 1 emphasizes graph interpretation and analysis. In this activity, verbal proficiency must be multiplied by the ability to comprehend and represent information as graphs (graphicacy). The provided information may be directly reflective of what we see (as in pictures or drawings) or more abstract, such as spatial (maps, plans, and diagrams) or numerical (charts, graphs, and tables) information (as in tables and graphs. There are several types of IELTS Writing Task 1, for example, pie charts, bar charts, bar graphs, line graphs, tables, maps, diagram processes, line and bar charts, also pie and bar charts. Each form of data visualization has its way of describing it. To complete the IELTS Writing Task 1, participants are required to write a minimum of 150 words of writing or an essay. We can divide the number of words into 3 paragraphs (introduction, body, and conclusion) to make it easier to write an essay according to the data presented. The IELTS Writing Task 1 can be fairly challenging, particularly if we have not prepared. Overcoming these challenges requires good preparation, consistent practice, and a deep understanding of the IELTS format, structure, and requirements.
Constructivism-based pathways: Revolutionizing EFL writing instruction for adult learners
Authors: Fitrianingsih Ihtiara 
Published: May 2024

In the ongoing pursuit of continuous pedagogical improvement, eclectic teachers find themselves inundated with a multitude of engaging approaches, methods, and techniques. The selection of these should ideally be based on informed pedagogy, with due consideration given to the particular needs of the learners. Through reflective self-inquiry , this paper aims to reveal how a thoughtful teacher reflects on her everyday teaching practices in order to transform them into a more constructivist model of instruction by the stages of initiation, focus on the self, data collection, taking accountability, iterative reflection, and information generation. A description is provided of how the EFL writing classes taught by the author at Universitas Negeri Yogyakarta were managed. This is then confronted with some literature about andragogy and constructivist learning, providing a proposed model for improving future constructivist-based EFL writing instruction for adult learners. The constructivist approach to EFL writing proposed involves several key steps, from conditioning, collaborative inquiry, engaging feedback, work display, to reflective exam, all of which become comprehensive stages within one semester learning in writing courses.
Prevalence, Mortality, and Access to Care for Chronic Kidney Disease in Medicaid-Enrolled Adults With Sickle Cell Disease in California: Retrospective Cohort Study
Authors: Valle Jhaqueline , Lebensburger Jeffrey D , Garimella Pranav S , Gopal Srila 
Published: May 2024

Background
Chronic kidney disease (CKD) is a significant complication in patients with sickle cell disease (SCD), leading to increased mortality.

Objective
This study aims to investigate the burden of CKD in Medicaid-enrolled adults with SCD in California, examine differences in disease burden between male and female individuals, and assess mortality rates and access to specialized care.

Methods
This retrospective cohort study used the California Sickle Cell Data Collection program to identify and monitor individuals with SCD. Medicaid claims, vital records, emergency department, and hospitalization data from 2011 to 2020 were analyzed. CKD prevalence was assessed based on ICD (International Classification of Diseases) codes, and mortality rates were calculated. Access to specialized care was examined through outpatient encounter rates with hematologists and nephrologists.

Results
Among the 2345 adults with SCD, 24.4% (n=572) met the case definition for CKD. The SCD-CKD group was older at the beginning of this study (average age 44, SD 14 vs 34, SD 12.6 years) than the group without CKD. CKD prevalence increased with age, revealing significant disparities by sex. While the youngest (18-29 years) and oldest (>65 years) groups showed similar CKD prevalences between sexes (female: 12/111, 10.8% and male: 12/101, 11.9%; female: 74/147, 50.3% and male: 34/66, 51.5%, respectively), male individuals in the aged 30-59 years bracket exhibited significantly higher rates than female individuals (30-39 years: 49/294, 16.7%, P=.01; 40-49 years: 52/182, 28.6%, P=.02; and 50-59 years: 76/157,48.4%, P<.001). During this study, of the 2345 adults, 435 (18.5%) deaths occurred, predominantly within the SCD-CKD cohort (226/435, 39.5%). The median age at death was 53 (IQR 61-44) years for the SCD-CKD group compared to 43 (IQR 33-56) years for the SCD group, with male individuals in the SCD-CKD group showing significantly higher mortality rates (111/242, 45.9%; P=.009) than female individuals (115/330, 34.9%). Access to specialist care was notably limited: approximately half (281/572, 49.1%) of the SCD-CKD cohort had no hematologist visits, and 61.9% (354/572) did not see a nephrologist during this study’s period.

Conclusions
This study provides robust estimates of CKD prevalence and mortality among Medicaid-enrolled adults with SCD in California. The findings highlight the need for improved access to specialized care for this population and increased awareness of the high mortality risk and progression associated with CKD.
Radiologic diagnosis of pneumothorax in combat trauma
Authors: Grechanik О.I. , Аbdullaiev R.R. , Nikonov V.V. , Voronzhev І.О. , Аbdullaiev R.Ya. , Davidy М.М. 
Published: May 2024

Background. Chest injuries during combat operations occupy a prominent place and often become the cause of mortality. Before the widespread introduction of imaging methods into clinical practice, the mortality rate for chest combat injuries exceeded 50 %. Objective: a comparative assessment of radiography and ultrasonography options in the diagnosis of pneumothorax that occurred as a result of combat trauma. Materials and methods. A comparative analysis of the radiography and ultrasonography results was carried out in 76 patients with pneumothorax due to chest combat trauma. Results. During X-ray in the supine position, the sensitivity of the method was 58.1 %, specificity — 72.7 %, accuracy — 64.5 %, positive predictive value — 73.5 %, negative predictive value — 57.1 %. The sensitivity of the method in the sitting position of patients was 71.9 %, specificity — 89.5 %, accuracy — 76.3 %, positive predictive value — 95.3 %, negative predictive value — 51.5 %. Ultrasound diagnosis of pneumothorax was based on identifying the “barcode” sign due to the lack of sliding of the visceral pleura during the patient’s inspiration. The sensitivity of ultrasonography in B-mode was 90.8 %, specificity — 81.8 %, accuracy — 89.5 %, positive predictive value — 96.7 %, negative predictive value — 60.0 %, and in combined B + M modes — 94.0, 88.9, 93.4, 98.4, 66.7 %, respectively. In the diagnosis of large pneumothorax, the sensitivity of radiography was 96.8 %, specificity — 100.0 %, accuracy — 96.9 %, positive predictive value — 100.0 %, negative predictive value — 50.0 %, respectively, and of ultrasonography — 96.7, 100.0, 96.9, 100.0, 66.7 %, respectively. Conclusions. Ultrasonography has greater sensitivity for diagnosing small pneumothorax than conventional radiography, especially in bedridden patients. Ultrasonography in combined B + M modes can be both a primary and a clarifying method for diagnosing pneumothorax in combat trauma.
ANALISIS MANAJEMEN PEMBIAYAAN PADA LEMBAGA KSPPS BMT AR-ROHMAH BANDONGAN MAGELANG
Authors: Rochison Muhammad , Fitriyani Yeny , Purwanto Purwanto , Rifki Muhammad , Hidayat Yahya Nur 
Published: May 2024

Shariah Savings and Credit and Finance Cooperatives (KSPPS) are microfinance institutions that collect and distribute assets to people who need these funds. This research aims to find out the financial management and internal and external systems in KSPPS BMT Ar-Rohmah Bandongan Magelang; this research uses a descriptive qualitative approach with interview techniques, primary and secondary data collection, and documentation. Using SWOT analysis, we can find the weaknesses, strengths, threats, and opportunities in KSPPS Ar-rohmah institution. The results of this study show that the management system in KSPPS BMT Ar-rohmah institution uses a Sharia financing system and has Sharia principles, as well as having several opportunities and weaknesses and threats for institutions; KSPPS BMT Ar-rohmah mitigates risks by paying attention to character, capacity, capital, collateral and economic conditions in customers.
TINGKAH LAKU INGESTIF KAMBING SABURAI INDUKAN BERANAK DUA PADA LAKTASI PERTAMA DAN KEDUA DI GISTING ATAS KECAMATAN GISTING KABUPATEN TANGGAMUS
Authors: Yamartha Yamartha , Adhianto Kusuma , Liman Liman , Qisthon Arif 
Published: May 2024

Tujuan dari penelitian ini untuk mengetahui tingkah laku ingestif dari kambing Saburai Indukan beranak dua dengan laktasi pertama dan kedua berdasarkan Tingkah Laku Makan Penelitian ini dilaksanakan pada bulan November 2021 yang bertempat di Kelompok Tani Makmur II di Desa Gisting Atas, Kecamatan Gisting, Kabupaten Tanggamus, Lampung. Penelitian ini menggunakan metode deskriptif kuantitatif dengan pengambilan data secara pengamatan dan di analisis menggunakan analisis deskriptif. Hasil dari penelitian ini menunjukkan bahwa rata – rata lama waktu makan kambing Saburai indukan laktasi pertama yaitu 395,71 menit/ hari atau 6,60 jam/hari, dan pada kambing Saburai indukan beranak dua yaitu 342,78 menit/hari atau 5,71 jam/hari. Rata -rata lama waktu istirahat pada kambing indukan laktasi pertama yaitu 1.057,73 menit/hari atau 17,63 jam/hari, dan pada kambing Saburai indukan laktasi kedua yaitu 1.054,40 menit/hari atau 17,57 jam/hari. Rata – rata lama waktu ruminasi pada kambing indukan laktasi pertama yaitu 419,77 menit/hari atau 7,00 jam/hari, dan pada kambing indukan laktasi kedua yaitu 467,39 menit/hari atau 7,79 jam/hari.