bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized trial of collaborative support for opioid taper after trauma hospitalization
Authors: Sullivan Mark D. , Katers Laura , Wang Jin , Arbabi Sam , Tauben David , Baldwin Laura-Mae 
Published: June 2024

AbstractThe COTAT (Collaborative Opioid Taper After Trauma) Study was a randomized trial of an opioid taper support program using a physician assistant (PA) to provide pain and opioid treatment guidance to primary care providers assuming care for adult patients with moderate to severe trauma discharged from a Level I trauma center on opioid therapy. Patients were recruited, assessed, and randomized individually by a surgery research recruitment team one to two days prior to discharge to home. Participants randomized to the opioid taper support program were contacted by phone within a few days of discharge by the PA interventionist to confirm enrollment and their primary care provider (PCP). The intervention consisted of PA support as needed to the PCP concerning pain and opioid care at weeks 1, 2, 4, 8, 12, 16, and 20 after discharge or until the PCP office indicated they no longer needed support or the patient had tapered off opioids. The PA was supervised by a pain physician-psychiatrist, a family physician, and a trauma surgeon. Patients randomized to usual care received standard hospital discharge instructions and written information on managing opioid medications after discharge. Trial results were analyzed using repeated measures analysis. 37 participants were randomized to the intervention and 36 were randomized to usual care. The primary outcomes of the trial were pain, enjoyment, general activity (PEG score) and mean daily opioid dose at 3 and 6 months after hospital discharge. Treatment was unblinded but assessment was blinded. No significant differences in PEG or opioid outcomes were noted at either time point. Physical function at 3 and 6 months and pain interference at 6 months were significantly better in the usual care group. No significant harms of the intervention were noted. COVID-19 (corona virus 2019) limited recruitment of high-risk opioid tolerant subjects, and limited contact between the PA interventionist and the participants and the PCPs. Our opioid taper support program failed to improve opioid and pain outcomes, since both control and intervention groups tapered opioids and improved PEG scores after discharge. Future trials of post-trauma opioid taper support with populations at higher risk of persistent opioid use are needed. This trial is registered at clinicaltrials.gov under NCT04275258 19/02/2020. This trial was funded by a grant from the Centers for Disease Control and Prevention to the University of Washington Harborview Injury Prevention & Research Center (R49 CE003087, PI: Monica S. Vavilala, MD). The funder had no role in the analysis or interpretation of the data.
An exercise and patient education intervention to reduce pain and physical limitations in adults with acetabular dysplasia: study protocol for a process evaluation integrated within a randomised controlled trial (the MovetheHip trial)
Authors: Jacobsen Julie S. , Evans Rhiannon , Morgan Kelly , Thorborg Kristian , Oestergaard Lisa G. , Sørensen Dorthe 
Published: June 2024

Abstract
Background
The Movethehip trial investigates the effectiveness of an exercise and patient education intervention for adults with acetabular dysplasia. The intervention involves eight tailored one-to-one sessions with trained providers who employ supportive feedback tools. The present protocol reports a planned process evaluation, which aims to determine how the intervention functions by examining the implementation of the intervention (process, dose and reach), its acceptability, mechanisms of change and the influence of contextual factors.

Methods
Two hundred trial participants aged 18–50 years will be recruited from a University Hospital in Denmark and randomised to the intervention or control group. Approximately ten providers will deliver the intervention. The process evaluation adopts a concurrent mixed-methods design. The implementation will be assessed using self-report questionnaires (at baseline and 6-month follow-up), training records and semi-structured focus group interviews with intervention providers (n = 10) and healthcare managers (n = 4–6). The mechanisms of change will be explored through semi-structured one-to-one interviews (at baseline and 6-month follow-up) with 15–20 purposefully sampled participants and by measuring changes in health outcomes (self-reported pain, physical functioning and quality of life completed at baseline and at 3- and 6-month follow-up). Additionally, change will be measured through an explorative examination of associations between dose and change in health outcomes, applying simple linear regression models. The acceptability of the intervention and the influence of contextual factors will be explored through one-to-one participant interviews and focus group interviews with 4–6 healthcare managers. The interviews will focus on expectations, experiences, events, personal understandings and interaction with interpersonal and organisational aspects. Interview data will be analysed using theoretical thematic analyses, and findings will be merged with quantitative data and reported jointly on a theme-by-theme basis.

Discussion
The process evaluation conducted as part of the MovetheHip trial will illuminate how the intervention functions, and if the intervention is proven effective, the findings of the evaluation will contribute to pinpoint how the intervention may be optimised to facilitate future up-scaling and implementation.

Trial registration
The MovetheHip protocol was approved by the Committee on Health Research Ethics in the Central Denmark Region. ClinicalTrials, NCT04795843. Registered on 20 March 2021.
Bronchobiliary fistula after traumatic liver rupture: a case report
Authors: Zhou Teng , Wu Wenming , Cheng Chao , Wang Hui , Hu Xiaochuan , Jiang Zhenhui 
Published: June 2024

Abstract
Introduction
Bronchobiliary fistulas are rare and difficult to treat. Peacock first reported this entity in 1850 while treating a patient with hepatic encopresis.

Case presentation
A 67-year-old Chinese male patient presented to the outpatient clinic with a complaint of coughing up phlegm with chest tightness for 4 days with symptoms of intermittent bilirubin sputum with a sputum volume of about 500 ml per day but no symptoms of abdominal pain or jaundice and no yellow urine or steatorrhea. The examination revealed cyanosis of the lips and mouth, barrel chest, low breath sounds on the right side, and a large number of wet rales heard in both lungs. The imaging investigations were suggestive of bronchobiliary fistula. Therefore, the patient was operated on and discharged with no perioperative complications.

Conclusion
Bronchobiliary fistula should be considered diagnostically in patients with known liver disease who also experience trauma or medical treatment and cough up bile-colored sputum, regardless of the presence of concurrent infections, and in conjunction with radiological expertise to identify it. Here, we report a case of bronchobiliary fistula and a brief review of the literature on it.
Peer review trends in six fisheries science journals
Authors: Midway Stephen R. , Hendee Laura , Daugherty Daniel J. 
Published: June 2024

Abstract
Background
As the production of scientific manuscripts and journal options both increase, the peer review process remains at the center of quality control. Recent advances in understanding reviewer biases and behaviors along with electronic manuscript handling records have allowed unprecedented investigations into the peer review process.

Methods
We examined a sample of six journals within the field of fisheries science (and all published by the American Fisheries Society) specifically looking for changes in reviewer invitation rates, review time, patterns of reviewer agreements, and rejection rates relative to different forms of blinding.

Results
Data from 6,606 manuscripts from 2011–2021 showed significant increases in reviewer invitations. Specifically, four journals showed statistically significant increases in reviewer invitations while two showed no change. Review times changed relatively little (± 2 weeks), and we found no concerning patterns in reviewer agreement. However, we documented a consistently higher rejection rate—around 20% higher—of double-blinded manuscripts when compared to single-blinded manuscripts.

Conclusions
Our findings likely represent broader trends across fisheries science publications, and possibly extend to other life science disciplines. Because peer review remains a primary tool for scientific quality control, authors and editors are encouraged to understand the process and evaluate its performance at whatever level can help in the creation of trusted science. Minimally, our findings can help the six journals we investigated to better understand and improve their peer review processes.
Social deprivation and spatial clustering of childhood asthma in Australia
Authors: Khan Jahidur Rahman , Lingam Raghu , Owens Louisa , Chen Katherine , Shanthikumar Shivanthan , Oo Steve , Schultz Andre , Widger John , Bakar K. Shuvo , Jaffe Adam , Homaira Nusrat 
Published: June 2024

Abstract
Background
Asthma is the most common chronic respiratory illness among children in Australia. While childhood asthma prevalence varies by region, little is known about variations at the small geographic area level. Identifying small geographic area variations in asthma is critical for highlighting hotspots for targeted interventions. This study aimed to investigate small area-level variation, spatial clustering, and sociodemographic risk factors associated with childhood asthma prevalence in Australia.

Methods
Data on self-reported (by parent/carer) asthma prevalence in children aged 0–14 years at statistical area level 2 (SA2, small geographic area) and selected sociodemographic features were extracted from the national Australian Household and Population Census 2021. A spatial cluster analysis was used to detect hotspots (i.e., areas and their neighbours with higher asthma prevalence than the entire study area average) of asthma prevalence. We also used a spatial Bayesian Poisson model to examine the relationship between sociodemographic features and asthma prevalence. All analyses were performed at the SA2 level.

Results
Data were analysed from 4,621,716 children aged 0–14 years from 2,321 SA2s across the whole country. Overall, children’s asthma prevalence was 6.27%, ranging from 0 to 16.5%, with significant hotspots of asthma prevalence in areas of greater socioeconomic disadvantage. Socioeconomically disadvantaged areas had significantly higher asthma prevalence than advantaged areas (prevalence ratio [PR] = 1.10, 95% credible interval [CrI] 1.06–1.14). Higher asthma prevalence was observed in areas with a higher proportion of Indigenous individuals (PR = 1.13, 95% CrI 1.10–1.17).

Conclusions
We identified significant geographic variation in asthma prevalence and sociodemographic predictors associated with the variation, which may help in designing targeted asthma management strategies and considerations for service enhancement for children in socially deprived areas.
Assessment of peripheral dose as a function of distance and depth from cobalt-60 beam in water phantom using TLD-100
Authors: Ahmad Habib , Ali Javaid , Ahmad Khalil , Biradar Ghufran , Zaman Ashfaq , Uddin Yasir , Sohail Muhammad , Ali Shahid 
Published: June 2024

Abstract
Background
Innovations in cancer treatment have contributed to the improved survival rate of cancer patients. The cancer survival rates have been growing and nearly two third of those survivors have been exposed to clinical radiation during their treatment. The study of long-term radiation effects, especially secondary cancer induction, has become increasingly important. An accurate assessment of out-of-field/peripheral dose (PDs) is necessary to estimate the risk of second cancer after radiotherapy and the damage to the organs at risk surrounding the planning target volume. This study was designed to measure the PDs as a function of dose, distances, and depths from Telecobalt-60 (Co-60) beam in water phantom using thermoluminescent dosimeter-100 (TLD-100).

Methods
The PDs were measured for Co-60 beam at specified depths of 0 cm (surface), 5 cm, 10 cm, and 15 cm outside the radiation beam at distances of 5, 10, and 13 cm away from the radiation field edge using TLD-100 (G1 cards) as detectors. These calibrated cards were placed on the acrylic disc in circular tracks. The radiation dose of 2000 mGy of Co-60 beam was applied inside 10 × 10 cm2 field size at constant source to surface distance (SSD) of 80 cm.

Results
The results showed maximum and minimum PDs at surface and 5 cm depth respectively at all distances from the radiation field edge. Dose distributions out of the field edge with respect to distance were isotropic. The decrease in PDs at 5 cm depth was due to dominant forward scattering of Co-60 gamma rays. The increase in PDs beyond 5 cm depth was due to increase in the irradiated volume, increase in penumbra, increase in source to axis distance (SAD), and increase in field size due to inverse square factor.

Conclusion
It is concluded that the PDs depends upon depth and distance from the radiation field edge. All the measurements show PDs in the homogenous medium (water); therefore, it estimates absorbed dose to the organ at risk (OAR) adjacent to cancer tissues/planning target volume (PTV). It is suggested that PDs can be minimized by using the SAD technique, as this technique controls sources of scattered radiation like inverse square factor and effect of penumbra up-to some extent.
A Rare Cyclic Cushing Syndrome Mystery Illustrates Diagnostic Principles
Authors: Omotosho Yetunde Bernice , McGlotten Raven , Pacak Karel , Wierman Margaret E , Nieman Lynnette K 
Published: June 2024

Abstract
Pheochromocytomas predominantly produce catecholamines, and rarely also produce ACTH, causing Cushing syndrome (CS). Cyclic CS, an uncommon presentation of hypercortisolism, poses a diagnostic challenge. We report a 71-year-old woman who developed cyclic ectopic ACTH secretion from a pheochromocytoma. Previous evaluations showed intermittent elevations in cortisol and ACTH levels, normal pituitary magnetic resonance imaging, and an adrenal nodule. On admission, she was hypertensive and had cushingoid features. Bilateral inferior petrosal sinus sampling with desmopressin stimulation and an 8-mg dexamethasone suppression test suggested ectopic ACTH secretion, but ACTH increased during the peripheral desmopressin stimulation test. Plasma normetanephrines were about 2-fold above the upper reference limit. 18F-fluoro-dopa and 68Gallium-DOTATATE positron emission tomography/computed tomography scans, computed tomography, and magnetic resonance imaging identified an adrenal mass. After doxazosin adrenoceptor blockade, she underwent right adrenalectomy; histopathology and immunohistochemistry confirmed an ACTH-secreting pheochromocytoma. Postoperative blood pressure normalized and serum cortisol and plasma ACTH levels were suppressed, requiring physiologic hydrocortisone replacement. This case underscores the importance of considering pheochromocytoma in ACTH-dependent hypercortisolism with elevated metanephrines and an adrenal mass. Timely diagnosis and treatment can reduce morbidity and improve quality of life.
Performance and Feminist Collectivizing
Authors: Myers Sarah , Granet Ilona , Henes Donna , Wilson Martha 
Published: June 2024

Abstract
On November 23, 2022, three original core members of the all-woman art collective DISBAND—Ilona Granet, Donna Henes, and Martha Wilson—sat down to discuss the therapeutic effects of collaborative performance, the role of comedy in addressing traumatic topics, and the activist potential of feminist collectivizing. Between 1978 and 1982, DISBAND performed in a diverse cultural circuit in downtown New York City where the burgeoning performance art, no wave, and feminist art scenes collided. The multidisciplinary backgrounds of the women in DISBAND matched the hybridity of this cultural circuit; other members included Barbara Kruger, Ingrid Sischy (former editor in chief of Artforum), Diane Torr (performance artist, drag king, and gender activist), Barbara Ess (photographer and member of the no wave band Y Pants), and Daile Kaplan (photographer and drummer of The Gynecologists). The women of DISBAND approached the song format fluidly, combining hymn, anthem, cheer, and protest movement (stomping, chanting, clapping) with rapid-fire improvisation. DISBAND's songs reflected the members’ personal and collective political concerns, often focusing directly on female oppression. The women's use of costumes, role-playing, and DIY instruments brought levity and playfulness to what they describe as an apocalyptic moment.
Patients May Return to Work Sooner After Laminoplasty: Occupational Outcomes of the Cervical Spondylotic Myelopathy Surgical Trial
Authors: Miranda Stephen P. , Whitmore Robert G. , Kanter Adam , Mummaneni Praveen V. , Bisson Erica F. , Barker Fred G. , Harrop James , Magge Subu N. , Heary Robert F. , Fehlings Michael G. , Albert Todd J. , Arnold Paul M. , Riew K. Daniel , Steinmetz Michael P. , Wang Marjorie C. , Heller John G. , Benzel Edward C. , Ghogawala Zoher 
Published: June 2024

BACKGROUND AND OBJECTIVES:
Return-to-work (RTW) is an important outcome for employed patients considering surgery for cervical spondylotic myelopathy (CSM). We conducted a post hoc analysis of patients as-treated in the Cervical Spondylotic Myelopathy Surgical Trial, a prospective, randomized trial comparing surgical approaches for CSM to evaluate factors associated with RTW.

METHODS:
In the trial, patients were randomized (2:3) to either anterior surgery (anterior cervical decompression/fusion [ACDF]) or posterior surgery (laminoplasty [LP], or posterior cervical decompression/fusion [PCDF], at surgeon's discretion). Work status was recorded at 1, 3, 6, and 12 months postoperatively. For patients working full-time or part-time on enrollment, time to RTW was compared across as-treated surgical groups using discrete-time survival analysis. Multivariate logistic regression was used to assess predictors of RTW. Clinical outcomes were compared using a linear mixed-effects model.

RESULTS:
A total of 68 (42%) of 163 patients were working preoperatively and were analyzed. In total, 27 patients underwent ACDF, 29 underwent PCDF, and 12 underwent LP. 45 (66%) of 68 patients returned to work by 12 months. Median time to RTW differed by surgical approach (LP = 1 month, ACDF = 3 months, PCDF = 6 months; P = .02). Patients with longer length-of-stay were less likely to be working at 1 month (odds ratio 0.51; 95% CI, 0.29-0.91; P = .022) and 3 months (odds ratio 0.39; 95% CI, 0.16-0.96; P = .04). At 3 months, PCDF was associated with lower Short-Form 36 physical component summary scores than ACDF (estimated mean difference [EMD]: 6.42; 95% CI, 1.4-11.4; P = .007) and LP (EMD: 7.98; 95% CI, 2.7-13.3; P = .003), and higher Neck Disability Index scores than ACDF (EMD: 12.48; 95% CI, 2.3-22.7; P = .01) and LP (EMD: 15.22; 95% CI, 2.3-28.1; P = .014), indicating worse perceived physical functioning and greater disability, respectively.

CONCLUSION:
Most employed patients returned to work within 1 year. LP patients resumed employment earliest, while PCDF patients returned to work latest, with greater disability at follow-up, suggesting that choice of surgical intervention may influence occupational outcomes.
Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival
Authors: Krishnamurthy Anjana , Lee Andrew S. , Bayin N. Sumru , Stephen Daniel N. , Nasef Olivia , Lao Zhimin , Joyner Alexandra L. 
Published: June 2024

ABSTRACT
The neurons of the three cerebellar nuclei (CN) are the primary output neurons of the cerebellum. The excitatory neurons (e) of the medial (m) CN (eCNm) were recently divided into molecularly defined subdomains in the adult; however, how they are established during development is not known. We define molecular subdomains of the mouse embryonic eCNm using single-cell RNA-sequencing and spatial expression analysis, showing that they evolve during embryogenesis to prefigure the adult. Furthermore, eCNm are transcriptionally divergent from cells in the other nuclei by embryonic day 14.5. We previously showed that loss of the homeobox genes En1 and En2 leads to loss of approximately half of the embryonic eCNm. We demonstrate that mutation of En1/2 in the embryonic eCNm results in death of specific posterior eCNm molecular subdomains and downregulation of TBR2 (EOMES) in an anterior embryonic subdomain, as well as reduced synaptic gene expression. We further reveal a similar function for EN1/2 in mediating TBR2 expression, neuron differentiation and survival in the other excitatory neurons (granule and unipolar brush cells). Thus, our work defines embryonic eCNm molecular diversity and reveals conserved roles for EN1/2 in the cerebellar excitatory neuron lineage.
Blended training activities in on-line and on-site exploration of the urban structures
Authors: Michał Stangel  
Published: June 2024

Training activities at the Architecture Faculty of Silesian University of Technology have shown the success of extending educational forms beyond traditional classes, and have incorporated interactive and immersive methods, such as workshops, site trips, Project Based Learning, interdisciplinary seminars, etc. Such practices resulted in better engagement from the students and generally improvement of the quality educational experiences. However, the lock-down and imposing of distant learning since March 2020 have largely limited the innovative teaching forms and limited them to online interaction through various communication platforms. While the university seems to have adapted very well to the new situation in terms of lectures, design studios and drawing consultations; it proved quite challenging to realize engaging seminars and vivid discussions. The paper presents authors search and experiments with methods of extending beyond basic content to fruitful discussions and evoking interest and enthusiasm in the students, to find immersive educational methods in the new situation. These included testing various available online tools for communication, teamwork and urban analyses; deliberately blending online communication with traditional paper sketching and note taking; online workshops with invited guest speakers; as well as mixing online classes with real-life on-site activities and analyses performed by the students. An opposite situation was also tested, where the teacher was located in the urban space, lecturing and recording clips for the ArchéA online course. The evaluation of the course has shown that the students have highly appreciated the created training milieu, which resulted in their commitment, activeness, eagerness to both sharing own experiences and teamwork, and generally evoked the desired sensitivity and interest in urbanity and understanding the urban structures.
Il Teatro Shakespeariano di Danzica. L'Alato
Authors: Renato Rizzi  
Published: June 2024

Il 23 aprile, giorno della nascita e della morte di William Shakespeare, è stato inaugurato il tetto apribile del nuovo Teatro Elisabettiano, che sarà inaugurato il prossimo settembre a Danzica. L'evento diventa l'occasione per celebrare allo stesso tempo le potenze plastiche del simbolo, che, disseminate nella metafisica dei luoghi (e della memoria), guidano le forze alla 'forma' e i valori e gli ideali che hanno sostenuto il tormentato processo storico della città baltica e della nazione polacca.