bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic Resonance Imaging of Kidney and Cyst Volume in Children with ADPKD
Authors: Cadnapaphornchai Melissa A. , Masoumi Amirali , Strain John D. , McFann Kim , Schrier Robert W. 
Published: November 2010

Summary

Background and objectives
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and has important clinical manifestations in childhood. Numerous studies have documented the superiority of magnetic resonance imaging (MRI) for serial monitoring of kidney and cyst volume in this condition in adults. However, no studies have examined the utility of MRI for serial assessment of kidney and cyst volume in children with ADPKD.

Design, setting, participants, & measurements
Subjects 4 to 21 years of age with ADPKD underwent abdominal MRI on an annual basis for 5 years. Subjects were grouped according to BP as hypertensive (HBP; BP ≥ 95th percentile for age, height, and gender) or as normotensive (NBP; BP < 95th percentile). Total kidney volume (TKV), cyst volume, and cyst number were assessed by stereology.

Results
MRI studies (n = 302) were obtained in 77 children with ADPKD. TKV and cyst volume were significantly increased in HBP versus NBP subjects. HBP subjects demonstrated a greater increase in fractional cyst volume over time versus NBP subjects. Cyst number increased more rapidly in HBP ADPKD children.

Conclusions
This is the first large-scale clinical study examining the utility of MRI for serial assessment of TKV, cyst volume, and cyst number in children with ADPKD. These results demonstrate that MRI is an acceptable means to follow these parameters in children with ADPKD. Because of the embryonic occurrence of cysts, interventional trials are needed in ADPKD children and MRI may be the preferred renal imaging approach.
Implications of the CKD-EPI GFR Estimation Equation in Clinical Practice
Authors: Schold Jesse D. , Navaneethan Sankar D. , Jolly Stacey E. , Poggio Emilio D. , Arrigain Susana , Saupe Welf , Jain Anil , Sharp John W. , Simon James F. , Schreiber Martin J. , Nally Joseph V. 
Published: November 2010

Summary

Background and objectives
Chronic kidney disease (CKD) is a significant public health problem whose diagnosis and staging relies upon GFR-estimating equations, including the new CKD-EPI equation. CKD-EPI demonstrated superior performance compared with the existing MDRD equation but has not been applied to a healthcare system.

Design, setting, participants, & measurements
We identified 53,759 patients with stages 3 to 5 CKD on the basis of either MDRD or CKD-EPI equations using two eGFR values <60 ml/min per 1.73 m2 >90 days apart from an outpatient setting. We compared patient characteristics, presence of related diagnosis codes, and time CKD classification between equations.

Results
The number of patients identified with CKD decreased 10% applying CKD-EPI versus MDRD. Changes varied substantially by patient characteristics including a 35% decrease among patients <60 years and a 10% increase among patients >90 years. Women, non-African Americans, nondiabetics, and obese patients were less likely to be classified on the basis of CKD-EPI. Time to CKD classification was significantly longer with CKD-EPI among younger patients. 14% of patients identified with CKD on the basis of either estimating equation also had a related ICD-9 diagnosis, ranging from 19% among patients <60 years to 7% among patients >90 years.

Conclusions
Consistent with findings in the general population, CKD-EPI resulted in substantial declines in equation-based CKD diagnoses in a large healthcare system. Further research is needed to determine whether widespread use of CKD-EPI with current guidelines could lead to delayed needed care among younger patients or excessive referrals among older patients.
Blood Pressure Control and Left Ventricular Mass in Children with Chronic Kidney Disease
Authors: Sinha Manish D. , Tibby Shane M. , Rasmussen Pernille , Rawlins Debbie , Turner Charles , Dalton R. Neil , Reid Christopher J.D. , Rigden Susan P.A. , Booth Caroline J. , Simpson John M. 
Published: November 2010

Summary

Background and objectives
Heart disease is a major cause of death in young adults with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) is common and is associated with hypertension. The aims of this study were to evaluate whether there is a relationship between LVH and BP in children with CKD and whether current targets for BP control are appropriate.

Design, setting, participants, & measurements
In this single-center cross-sectional study, 49 nonhypertensive children, (12.6 ± 3.0 years, mean GFR 26.1 ± 12.9 ml/min per 1.73 m2) underwent echocardiographic evaluation and clinic and 24-hour ambulatory BP monitoring. LVH was defined using age-specific reference intervals for left ventricular mass index (LVMI). Biochemical data and clinic BP for 18 months preceding study entry were also analyzed.

Results
The mean LVMI was 37.8 ± 9.1 g/m2.7, with 24 children (49%) exhibiting LVH. Clinic BP values were stable over the 18 months preceding echocardiography. Patients with LVH had consistently higher BP values than those without, although none were overtly hypertensive (>95th percentile). Multiple linear regression demonstrated a strong relationship between systolic BP and LVMI. Clinic systolic BP showed a stronger relationship than ambulatory measures. Of the confounders evaluated, only elemental calcium intake yielded a consistent, positive relationship with LVMI.

Conclusions
LVMI was associated with systolic BP in the absence of overt hypertension, suggesting that current targets for BP control should be re-evaluated. The association of LVMI with elemental calcium intake questions the appropriateness of calcium-based phosphate binders in this population.
Neutrophil Gelatinase-Associated Lipocalin in the Diagnosis of Type 1 Cardio-Renal Syndrome in the General Ward
Authors: Alvelos Margarida , Pimentel Rodrigo , Pinho Elika , Gomes André , Lourenço Patricia , Teles Maria José , Almeida Pedro , Guimarães João Tiago , Bettencourt Paulo 
Published: November 2010

Summary

Background and objectives
The early identification of acute heart failure (HF) patients with type 1 cardio-renal syndrome should be the first step for developing prevention and treatment strategies for these patients. This study aimed to assess the performance of neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C in the early detection of type 1 cardio-renal syndrome in patients with acute HF.

Design, setting, participants, & measurements
One-hundred nineteen patients admitted with acute HF were studied. NGAL and creatinine were measured in the first hospitalization morning; creatinine was also measured at least after 48 to 72 hours. Physicians were blinded to NGAL and cystatin C levels. Type 1 cardio-renal syndrome was defined as an increase in the creatinine level of at least 0.3 mg/dl or 50% of basal creatinine.

Results
Type 1 cardio-renal syndrome developed within 48 to 72 hours in 14 patients (11.8%). Admission NGAL levels were higher in these patients: 212 versus 83 ng/dl. At a cutoff value of 170 ng/L, NGAL determined type 1 cardio-renal syndrome with a sensitivity of 100% and a specificity of 86.7%. The area under the receiver-operating characteristic curve of NGAL was 0.93 and that of cystatin C was 0.68.

Conclusions
Above a cutoff value of 170 ng/L, NGAL predicts 48- to 72-hour development of type 1 cardio-renal syndrome with a negative predictive value of 100% and a positive predictive value of 50%. NGAL independently associates with type 1 cardio-renal syndrome and might be a useful biomarker in the early recognition of these patients.
Wound Healing in the Paranasal Sinuses after Coblation, Part II: Evaluation for Endoscopic Sinus Surgery using a Sheep Model
Authors: Swibel-Rosenthal Laura H. , Benninger Michael S. , Stone Chad H. , Zacharek Mark A. 
Published: November 2010

Background A previous study on wound healing with a rabbit model showed thermal injury to sinus mucosa with complete respiratory re-epithelialization by postoperative day (POD) 29. This study was designed to further understand the pattern of injury using the bipolar radiofrequency plasma process used by the Coblator and evaluate postprocedure healing. Methods Based on experience with our rabbit model, three sheep underwent endoscopic sinus surgery. Coblation was applied to inferior turbinate mucosa in three areas for 2, 4, or 6 seconds. After resection of the contralateral middle turbinate and ethmoidectomy, Coblation was applied to the lateral wall or lamina papyracea for 2 seconds. The ethmoid and turbinate specimens were resected en bloc during necropsy immediately for the first sheep and on POD 14 for the others. Results Coblation resulted in immediate loss of surface respiratory epithelium and thermal-type injury to the underlying seromucinous glands. On POD 14, the Coblation site showed re-epithelialization with respiratory epithelium. The underlying seromucinous glands were replaced by mild fibrosis. A small, well-defined zone of injury was shown. Longer use did not result in a deeper injury. Rather, the depth of injury was dependent on the type of submucosal tissue present. Underlying bone was associated with reactive, regenerative changes. No histological changes were shown in the orbit. Conclusion The effects of Coblation on sheep mucosa show a similar injury and healing pattern to that shown on rabbit mucosa. Based on this work and the previous rabbit study, the Coblator may be an additional tool for use in endoscopic sinus surgery.
Review of Patients Admitted to a Specialist Inpatient Parent-Infant Psychiatric Service
Authors: Nair Revi , Bilszta Justin , Shafira Nadia , Salam Nilam , Buist Anne 
Published: November 2010

Objective: The aim of this paper is to review the clinical, demographic and psychosocial characteristics of consecutive admissions to a specialist inpatient parent-infant psychiatric service during a 2-year period. Methods: Data from consecutive admissions between January 2006 and December 2007 were evaluated in terms of primary and secondary diagnosis, demographics and psychosocial risk, psychiatric history, referral source, inpatient care and child protection involvement. Results: The majority of admissions (n = 149) recorded during the audit period were for a major depressive disorder (n = 69; 46%), schizophrenia (n = 29; 19%) or postnatal psychosis (n = 19; 13%); the most common comorbidities were a physical health problem (35%), substance abuse (24%) or borderline personality disorder (15%). The average length-of-stay was 23.8 ± 15.5 days; the average baby's age at admission was 15.1 ± 11.6 weeks. There were no statistically significant differences between women with a history of a mood disorder and those with no such history, in any of the demographic or psychosocial variables evaluated. Conclusion: This paper provides a unique appraisal of those individuals actively seeking psychiatric assessment and treatment through a specialist perinatal psychiatric service. Such information is useful in promoting better understanding of this population and the complex treatment and management needs of this patient group.
La passion du dire
Authors: Stitou Rajaa 
Published: November 2010

Résumé La pensée gorienne est à la fois animée et habitée par la passion du dire et l’amour de la langue. Deux grandes étapes peuvent se distinguer dans son trajet. La première porte sur l’épistémologie. En effet, l’une de ses préoccupations majeures était d’abord la validité de la psychanalyse comme méthode et comme théorie. Il va ensuite orienter son regard vers ce qu’il en est du sujet en proie au politique et vers les montages anthropologiques par lesquels transite ce qui lie le singulier et le collectif, la subjectivité et le fait culturel. C’est ce qui retiendra alors toute son attention afin d’ouvrir les questions cruciales qui se posent à nous, dans une actualité brûlante, face aux « mutations anthropologiques » et à « la recomposition » des dispositifs permettant aux hommes de se soutenir dans le monde et de réguler les liens entre eux. Mais dans les deux approches, le langage et la parole occupent une place fondamentale. Ils tiennent lieu de boussole.
La médecine, la psychanalyse et les surprises du psychologue
Authors: Keller Pascal-Henri 
Published: November 2010

Résumé Spécialité médicale dont la psychanalyse est issue, la neurologie fait mine aujourd’hui d’ignorer cette filiation. Diverses recherches actuelles en neurobiologie laissent entrevoir les conséquences redoutables d’une telle ignorance. En effet, agir sur les circuits neuronaux du consommateur sans en passer par la parole correspond à leur ambition affichée. L’asservissement de l’humain, dénoncé sous toutes ses formes par Roland Gori, triompherait-il sous le masque de la « neuroéconomie » ? Loin d’être définies une fois pour toutes, les relations entre psychique et organique sont l’enjeu d’un questionnement incessant. Il y va du respect qu’elle se doit à elle-même que la psychanalyse apporte ici sa contribution, loin de tout conformisme et se situant hors de portée de la pensée unique.
Entre le commensurable et l'érotique
Authors: Bonnet Christian 
Published: November 2010

Résumé Le texte de Roland Gori est un dispositif rhétorique. Approcher ce dispositif est possible par un autre dispositif : celui de l’Annonciation tel qu’analysé par Daniel Arasse. Les trois composantes de la « perspective » sont rapprochées des trois caractéristiques du texte gorien. Les notions de commensurable et d’incommensurable permettent enfin de lier le dispositif rhétorique à des mouvements transférentiels.
L'évaluation d'un parcours
Authors: Sauret Marie-Jean 
Published: November 2010

Résumé Après un bref rappel de la façon dont la route de l’auteur et celle de Roland Gori se sont croisées, l’article récapitule quelques-unes des thèses qui orientent ou découlent des travaux portant sur l’articulation du sujet et du lien social – non sans indiquer en quoi elles participent, à l’occasion du travail de Roland Gori et Marie-José Del Volgo. L’énumération prend son départ dans la conception que la psychanalyse fournit du sujet de la parole, du lien social comme relevant d’un certain usage du discours pour faire tenir lesdits sujets ensemble, et de la distinction avec d’autres modalités du social… Elle situe l’enjeu de la place accordée à l’indétermination du sujet comme condition de l’acte, ainsi que la fonction du symptôme comme solution subjective pour lier la singularité dans un « vivre ensemble ». Elle invite à prendre la mesure de la mutation anthropologique qu’entraînent les changements imposés par les transformations du savoir – et notamment l’avènement du scientisme et de sa collusion néolibérale avec le marché. L’objectif étant, à terme, de contribuer à la discussion des moyens à notre disposition comme à mettre en œuvre – véritable politique qui requiert une logique collective – pour un renouvellement viable du lien social.
Être victime
Authors: Jacobi Benjamin 
Published: November 2010

Résumé La victime n’est pas le sujet. Cette assertion vive est développée à partir de deux situations cliniques : l’une concerne une maladie grave, l’autre un abus sexuel. La compassion et l’identification massive sont notamment repérées dans leur effet de délaissement du sujet. Le silence consécutif à l’expérience traumatisante est associé à l’irruption brutale du Réel, il est également envisagé dans une dimension socio-historique. Enfin la mise en exil de l’intime (R. Gori et M.-J. Del Volgo) et la pratique du debriefing sont confrontées aux risques d’atteinte narcissique renouvelés.
Biometry of the Cornea in Myopic Chinese Patients
Authors: Bao Fang-Jun , Yu A-Yong , Kassem Wael , Wang Qin-Mei , Elsheikh Ahmed 
Published: November 2010

Purpose:
To develop a close-fit mathematical model of corneal anterior and posterior topography and investigate the variation of corneal topography with biometric parameters in a group of young adult myopic Chinese patients.

Methods:
Corneal topography data were acquired from 112 eyes of 61 myopic patients (mean age: 24.10±3.66 years). Videokeratoscopic images were recorded for anterior and posterior corneal surfaces using an Orbscan IIz topography system (Bausch & Lomb), and elevation data were fit to ellipsoid, hyperboloid, and paraboloid equations. Axial length, anterior chamber depth, refractive error, corneal curvature, central corneal thickness, and white-to-white distance were also measured and statistically analyzed.

Results:

The ellipsoid equation provided the best fit for the anterior and posterior corneal surfaces in all patients. Corneal asymmetry slightly improved the accuracy of the mathematical model and reduced errors of fit with the clinical data. Strong evidence of right and left corneal symmetry was obtained in the form of similar corneal curvature, shape factor, and thickness values. The refractive error showed strong correlation with axial length (r=−0.586,
P
<.001) but not with corneal curvature or anterior chamber depth, indicating that myopia may be related to scleral stretching and globe elongation rather than changes in corneal curvature or anterior chamber depth.

Conclusions:
Axial length appears to be the main morphological parameter related to myopia. Myopic corneas took the form of a rotationally asymmetric prolate ellipsoid that gradually flattened towards the periphery. The study also provided evidence of symmetry between an individual’s right and left corneas.
Quantification of Change in Axonal Birefringence Following Surgical Reduction in Intraocular Pressure
Authors: Sehi Mitra , Grewal Dilraj S. , Zhu Haogang , Feuer William J. , Greenfield David S. 
Published: November 2010

Background and Objective:
The purpose of this study was to examine the hypothesis that retinal nerve fiber layer (RNFL) birefringence increases following surgical reduction of intraocular pressure (IOP).

Patients and Methods:
Twenty-six glaucomatous eyes requiring trabeculectomy or drainage implant were enrolled. Optical coherence tomography (OCT), scanning laser polarimetry (SLP), and IOP measurements were performed preoperatively and 3 months postoperatively. The OCT and SLP images were aligned using a new algorithm that aligns the vessels in an OCT image to those in the corresponding SLP reflectance image. The SLP retardance values at the location of the OCT scan circle were then extracted using the OCT scan circle position inferred by the algorithm. Sixty-four corresponding RNFL segments were extracted from SLP and OCT to calculate RNFL birefringence. A significant birefringence change was defined as 1.96 times the weighted test–retest standard deviation in four contiguous segments.

Results:

Preoperative IOP (19.3 ± 6.1 mm Hg) was significantly (
P
< .001) lower than postoperative IOP (10.4 ± 3.7 mm Hg). Average birefringence magnitude did not change (
P
= .19) postoperatively. Localized birefringence magnitude increased significantly in 6 (23%) eyes and decreased significantly in 7 (27%) eyes.

Conclusion:
In this cohort, variable changes in localized birefringence were observed following surgical reduction of IOP.
Antiplatelet Activity of Valproic Acid Contributes to Decreased Soluble CD40 Ligand Production in HIV Type 1-Infected Individuals
Authors: Davidson Donna C. , Hirschman Michael P. , Spinelli Sherry L. , Morrell Craig N. , Schifitto Giovanni , Phipps Richard P. , Maggirwar Sanjay B. 
Published: November 2010

Abstract
CD40L is a type II membrane glycoprotein of the TNF family that is found on activated T cells, B cells, and platelets. We previously reported that the soluble form of this inflammatory mediator (sCD40L) is elevated in the plasma and cerebrospinal fluid of HIV-1–infected, cognitively impaired individuals. In this study, we demonstrate that the mood-stabilizing drug valproic acid (VPA) reduces sCD40L levels in plasma samples of HIV-1–infected patients (n = 23) and in washed human platelets, which are the main source of circulating sCD40L. VPA also inhibited HIV-1 transactivator of transcription-induced release of sCD40L and platelet factor 4 in C57BL/6 mice. The mechanism by which VPA was able to do so was investigated, and we demonstrate that VPA, a known glycogen synthase kinase 3β inhibitor, blocks platelet activating factor-induced activation of glycogen synthase kinase 3β in platelets in a manner that alters sCD40L release from platelets. These data reveal that VPA has antiplatelet activity, and they convey important implications for the potential of VPA as an adjunct therapy not only for cognitively impaired patients with HIV-1 infection, but also numerous inflammatory diseases for which such antiplatelet therapies are currently lacking.
Treatment of epidural spinal cord involvement from germ cell tumors with chemotherapy
Authors: Grommes Christian , Bosl George J. , DeAngelis Lisa M. 
Published: November 2010

AbstractBACKGROUND:Germ cell tumors (GCTs) are chemosensitive, and epidural spinal cord compression (ESCC) from GCT may be amenable to treatment with chemotherapy (CT) only. This retrospective study compares the clinical outcome of GCT patients with ESCC treated with CT or radiotherapy (RT) + CT.METHODS:All patients with a histologic diagnosis of GCT from 1984 to 2009 were included in this study. Patients with ESCC were identified. Age, clinical features, histology, treatment, and outcome were analyzed.RESULTS:The authors identified 1734 patients with GCT, of whom 29 (1.7%) had ESCC. The median age of these 29 patients was 32 years. The ESCC was treated with CT only in 16, RT + CT in 11, and 2 patients received palliative care only. The ESCC was more extensive in the RT + CT than the CT group. Patients who received RT + CT had a higher proportion of failed prior CT regimens, a higher percentage of nonseminomatous GCT, T‐spine involvement, multilevel epidural disease, and bony vertebral metastases. Median overall survival after diagnosis of ESCC was not reached for those treated with CT alone versus 15 months for those receiving RT + CT (P = .02). There was also a significant difference in survival in patients receiving first‐line therapy (n = 15), where median overall survival was not reached in the CT group (n = 11), compared with 22 months in the RT group (n = 4) (P = .04).CONCLUSIONS:GCTs rarely involve the epidural compartment. Patients with ESCC who are likely to have chemosensitive disease can receive CT alone as definitive treatment. Cancer 2011. © 2010 American Cancer Society.
Synthesis and Characterization of Unusual Oxidorhenium(V) Cores
Authors: Nguyen Hung Huy , Hazin Khatera , Abram Ulrich 
Published: November 2010

AbstractReactions of (NBu4)[ReOCl4] with N‐(N″,N″‐dialkylaminothiocarbonyl)‐N′‐(2‐hydroxyphenyl)benzamidines (H2L1) give complexes of the compositions [ReOCl(L1)] (1), cis‐[ReO(L1)(OMe)] (2), or cis,cis‐[{ReO(L1)}2O] (3) depending on the conditions applied. Compound 3 contains a bridging oxygen atom in the cis position to the terminal oxido ligands of both rhenium atoms. The analogous dimeric, sulfur‐bridged compound [{ReO(L1)}2S] (4) was obtained by the reaction of 1 with Na2S.