bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angina Pectoris, Intermittent Claudication and Congestive Heart Failure in Middle‐aged Male Hypertensives
Authors: SAMUELSSON OLA , WILHELMSEN LARS , PENNERT KJELL , BERGLUND GÖRAN 
Published: August 2010

ABSTRACT.Samuelsson O, Wilhelmsen L, Pennert K, Berglund G (Section of Preventive Cardiology, Department of Internal Medicine I, Sahlgrenska and Östra Hospitals, University of Göteborg, Göteborg, Sweden). Angina pectoris, intermittent claudication and congestive heart failure in middle‐aged male hypertensives. Acta Med Scand 1987; 221:23–32.A group of middle‐aged male hypertensives, derived from a random sample of a Swedish urban population, has been treated and followed for 10 years. The development of angina pectoris, intermittent claudication and congestive heart failure have been analysed. The initial prevalence and the average yearly incidence of angina pectoris was 3.9% and 1.3% p.a., of intermittent claudication 1.7% and 0.6% p.a. and of heart failure 1.0% and 0.8% p.a. ECG signs indicating subclinical heart disease (major Q wave, STdepression, T wave inversion) were risk factors for development of angina pectoris and congestive heart failure. Heart enlargement on chest X‐ray was also a risk factor for development of congestive heart failure, as were a high serum creatinine, body mass index, serum uric acid and proteinuria. Smoking was found to be a strong and independent risk factor for any one of these cardiovascular disorders. After 10 years about one fourth of all patients, still attending the clinic, had at least one cardiovascular complication. Hence, the risk of developing cardiovascular disorders is substantial and seems to be potentiated by the same risk factors known to operate in the general population.
The Clinical Picture of the Painful Diabetic Shoulder—Natural History, Social Consequences and Analysis of Concomitant Hand Syndrome
Authors: MORÉN‐HYBBINETTE INGALILL , MORITZ ULRICH , SCHERSTÉN BENGT 
Published: August 2010

ABSTRACT.Morén‐Hybbinette I, Moritz U, Scherstén B (Department of Physical Medicine, University Hospital, Lund and Department of Community Health Sciences, University of Lund, Dalby, Sweden). The clinical picture of the painful diabetic shoulder—natural history, social consequences and analysis of concomitant hand syndrome. Acta Med Scand 1987; 221:73–82.Sixty diabetic patients with shoulder pain were followed in order to trace the natural history of the disease. The triad of painful shoulder, hand syndrome and restricted hip joint mobility was strongly correlated to the duration of diabetes and retinopathy. Painful shoulder with restricted mobility (58%) and tendinitis (28%) predominated. Hand syndrome was found in 62% and restricted hip joint mobility in 42%. Ninety percent of painful shoulders with restricted mobility had difficulties in the activities of daily living in the acute phase. There was functional limitation of shoulder mobility in 17% of painful shoulders with restricted mobility at the end of the study. The duration of diabetes and the duration of shoulder symptoms were correlated. In 25%, working capacity was affected by the painful shoulder. A serious risk of developing shoulder symptoms persisting for more than 2 years was associated with insulin treatment, diabetes lasting more than 10 years, proliferative retinopathy and painful shoulder with restricted mobility.
Localized Primary Amyloidosis of the Stomach Presenting with Gastric Hemorrhage
Authors: BJÖRNSSON SIGURDUR , JÓHANNSSON JÓHANN HEIDAR , SIGURJÓNSSON FROSTI 
Published: August 2010

ABSTRACT. Bjdrnsson S, Jóhannsson JH, Sigurjónsson F (Departments of Internal Medicine and Surgery, Reykjavik City Hospital, and Department of Pathology, University of Iceland, Reykjavik, Iceland). Localized primary amyloidosis of the stomach presenting with gastric hemorrhage. Acta Med Scand 1987; 221:115–9.We report a patient with localized, primary gastric amyloidosis, who presented with recurrent hematemesis, a rare presentation for an unusual disease. The patient was initially thought to have stomach cancer because of the X‐ray and gastroscopic appearance of the gastric mucosa, but was eventually found to have primary amyloidosis confined to the stomach and regional lymph nodes. The amyloid was found to be of immunoglobulin origin, AL amyloid. Other reports of localized gastric amyloidosis are reviewed and compared with the present case. Most of the patients were clinically suspected of gastric carcinoma, and only one had hematemesis. We propose that amyloidosis should be considered in the differential diagnosis of hematemesis and gastric tumors.
Amiodarone for Refractory Supraventricular Tachycardias
Authors: EMMERTSEN K. , BJERREGAARD P. , ANDREASEN F. 
Published: August 2010

ABSTRACT. Emmertsen K, Bjerregaard P, Andreasen F (Department of Cardiology, Aarhus Kommunehospital and Institute of Pharmacology, University of Aarhus, Aarhus, Denmark). Amiodarone for refractory supraventricular tachycardias. Acta Med Scand 1987; 221:435–9.Amiodarone was administered to 53 patients with otherwise drug‐refractory supraventricular tachycardias. Therapy was effective in 35 patients and partially effective in nine patients for a median duration of 35 months. The median maintenance dose was 200 mg/day in both groups, whereas the median serum amiodarone concentrations were 1.1 mg/l and 0.7 mg/l, respectively. Amiodarone was ineffective in nine patients despite higher dosage (median 400 mg/day) and insignificantly higher serum concentrations (median 2.0 mg/l). Neither the age of the patients, the duration or type of arrhythmia, the cardio‐thoracic index, nor the type of underlying heart disease were predictive of the efficacy of amiodarone. Side‐effects occurred in 28 patients, leading to withdrawal of therapy in 12 patients. Side‐effects were not associated with higher serum amiodarone concentrations. Despite its efficacy, amiodarone should be reserved for otherwise drug‐resistant supraventricular tachyarrhythmias.
Changes in Plasma Atrial Natriuretic Peptide during Exercise in Healthy Volunteers
Authors: THAMSBORG GORM , STORM TOMMY , KELLER NIELS , SYKULSKI ROMAN , LARSEN JOHN 
Published: August 2010

ABSTRACT.Thamsborg G, Storm T, Keller N, Sykulski R, Larsen J (Departments of Clinical Chemistry and Internal Medicine, Sundby Hospital, Copenhagen, and Department of Cardiology, Hvidovre Hospital, Hvidovre, Denmark). Changes in plasma atrial natriuretic peptide during exercise in healthy volunteers. Acta Med Scand 1987; 221:441–4.Graded exercise was performed in three healthy volunteers. Plasma levels of immunoreactive atrial natriuretic peptide (iANP) were determined at different workloads. Unchanged or slightly decreased plasma levels of iANP were observed during light exercise, whereas at medium to high workloads a considerable increase in plasma levels of iANP was found. Factors responsible for the increase in plasma levels of iANP might include elevated right atrial pressure and increased plasma levels of epinephrine and norepinephrine.
Spontaneous Regression of Budd‐Chiari Syndrome (Hepatic Venous Occlusion) in a Young Female
Authors: HULTCRANTZ ROLF , ANGELIN BO , EINARSSON KURT , FRIMAN LEIF 
Published: August 2010

ABSTRACT. Hultcrantz R, Angelin B, Einarsson K, Friman L (Departments of Internal Medicine and Roentgenology, Serafimer Hospital, and Department of Internal Medicine, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden). Spontaneous regression of Budd‐Chiari syndrome (hepatic venous occlusion) in a young female. Acta Med Scand 1987; 221:503–7.A case of occlusion of the hepatic veins in an 18‐year‐old girl is presented. The onset was sudden with massive ascites and markedly impaired general condition. The diagnosis was based on liver biopsy and angiograms of the caval and hepatic veins as well as of the celiac artery. No predisposing factors could be found. The patient was treated conservatively with laparo‐centesis and diuretics. Clear improvement was seen after two weeks, and after four weeks she had no ascites and could be discharged. All liver function tests were then normalized. After three months, all diuretics could be withdrawn, and in the following 11 years she has remained completely recovered. The case illustrates that also widespread thrombi of the hepatic veins may sometimes rapidly dissolve spontaneously, with apparent total reconstitution of hepatic function. This case is unusual since previously reported cases have had high mortality rates and, in surviving cases, operative procedures or large doses of diuretics have been required to control the ascites.
Ibuprofen‐induced Meningitis in a Male with Systemic Lupus Erythematosus
Authors: JENSEN SØREN , GLUD TORBEN K. , BACHER THEIS , ERSGAARD HANS 
Published: August 2010

ABSTRACT. Jensen S, Glud TK, Bacher T, Ersgaard H (Departments of Endocrinology, Clinical Immunology and Anaesthetics, Aalborg Hospital, Aalborg, Denmark). Ibuprofen‐induced meningitis in a male with systemic lupus erythematosus. Acta Med Scand 1987; 221:509–11.A 36‐year‐old male with systemic lupus erythematosus developed aseptic meningitis after in‐gestion of ibuprofen. He was unconscious, had a universal rash, high fever and a pathological CSF. Being severely ill he was treated with high doses of corticosteroids and plasmapheresis and recovered within a week.Ibuprofen, a non‐steroidal anti‐inflammatory drug of the propionic acid group, is frequently used in patients with connective tissue disorders. Within the past eight years a few reports have been published on aseptic meningitis following ingestion of ibuprofen in patients with systemic lupus erythematosus (SLE) (1–5) and mixed connective tissue disease (6–8). All of these patients were women. We report a serious case of aseptic meningitis in a male subject with SLE.
Determinants of Long‐term Mortality after Stroke
Authors: VIITANEN M. , ERIKSSON S. , ASPLUND K. , WESTER P. O. , WINBLAD B. 
Published: August 2010

ABSTRACT.Viitanen M, Eriksson S, Asplund K, Wester PO, Winblad B (Departments of Internal Medicine and Geriatric Medicine, University of Umeå, Umeå, Sweden). Determinants of long‐term mortality after stroke.Risk factors of death for a population of 409 patients with well‐defined cerebrovascular disease (patients with subarachnoidal hemorrhage excluded) admitted to the Stroke Unit were studied with the aid of the life table technique, log rank test, and multivariate analysis with BMDP's program for regression on the survival curves with Cox's proportional hazard model. The estimated proportion of survivors was 77% after three months, 69% after one year, and 32% after five years. Patients with intracerebral hemorrhage and embolic cerebral infarction had the worst outcome. Impaired consciousness on admission was the most important risk factor of death followed by high age, previous cardiac failure, diabetes mellitus and male sex.
Increase in Hepatic Lipase Activity after Testosterone Substitution in Men with Hypogonadism of Pituitary Origin
Authors: VALDEMARSSON STIG , HEDNER PAVO , NILSSON‐EHLE PETER 
Published: August 2010

ABSTRACT. Valdemarsson S, Hedner P, Nilsson‐Ehle P (Departments of Internal Medicine and Clinical Chemistry, University Hospital, Lund, Sweden). Increase in hepatic lipase activity after testosterone substitution in men with hypogonadism of pituitary origin.Ten men with hypogonadism of pituitary origin were studied before and during testosterone substitution therapy with regard to effects on the activities of hepatic lipase (HL) and lipoprotein lipase (LPL) in postheparin plasma, and on plasma lipoprotein concentrations. The mean (±SEM) testosterone level increased from 1.8±0.5 to 16.3±2.4 nmol/l). The mean activity of HL rose from 327.1 ±35.2 to 432.8±57.2 mU/ml (p<0.02), while the activity of LPL did not change significantly, 71.0+9.1 mU/ml before and 62.2±3.8 mU/ml after treatment. No significant alterations in lipoprotein concentrations were recorded. These results indicate that a normal testosterone level is of importance for maintaining the activity of HL in men, thereby contributing to the sex difference previously recorded for HL activity.
Use of Computerized Databases to Survey Drug Utilization in Relation to Diagnoses
Authors: STROM BRIAN L. , MORSE M. LEE 
Published: August 2010

ABSTRACTMany studies of drug utilization have suffered from the absence of information on the indications for therapy. A few data sets on drug utilization are available which include indication information. In addition, a number of computerized collections of medical billing data now exist in North America which can be used for such studies. These include data from the Kaiser Permanente Medical Plan; the Group Health Cooperative of Puget Sound; the Commission on Professional and Hospital Activities' Professional Activity Study; the U.S. state of Rhode Island; the Saskatchewan Health Plan in Canada; and Medicaid, the state run but federally financed health insurance plan for economically or medically needy individuals in the United States. These databases have a number of general advantages and disadvantages, which are reviewed. In addition, the differences among these databases are also explored. Finally, examples are presented demonstrating how these databases can be used for: 1) descriptive research on drug utilization, 2) evaluating the appropriateness of drug utilization, and 3) interventions designed to improve the appropriateness of prescribing.
Reversibility of alcohol‐related brain damage: Clinical and experimental observations
Authors: Carlen Peter L , Wilkinson D Adrian 
Published: August 2010

AbstractChronic alcoholics who maintain abstinence often demonstrate remarkable improvement of neurological and mental dysfunction. This paper presents an overview of the clinical and laboratory work of our group. Reversible clinical manifestations include psychometric scores, ataxia, tremor, Parkinsonism, dyskinesia, cerebral atrophy, EEG parameters, and a CSF acidosis. Electrophysiological investigations showed that in the in vitro hippocampus of rats fed ethanol for several months there was evidence for diminished long‐term potentiation, impaired neuronal inhibitory mechanisms (diminished inhibitory postsynaptic potentials and post‐spike after hyperpolarisations), decreased neuronal specific membrane capacitance and increased specific membrane resistance. Golgi stains sho wed attenuation of hippocampal CA1neuronal dendrites in rats fed ethanol for five months, which reverted to control size in rats permitted two months of alcohol withdrawal.
Brain lesions in alcoholics: Neuropathological observations
Authors: Torvik Ansgar 
Published: August 2010

AbstractExamination of the autopsy material from a city hospital in Oslo gave the following results:

The brain weight of male alcoholics was significantly lower than that of age‐matched controls in all 10‐year age groups from 40 to 69 years. The mean weight reduction was 31 g.
Combined morphometric and histologic studies demonstrated atrophy of the anterior vermis in 42 per cent of all male alcoholics under 70 years of age. In cases over 70 years, 33 per cent of the non‐alcoholic controls showed atrophy of the anterior vermis. This is assumed to be a consequence of physiologic ageing. The prevalence of alcoholic cerebellar atrophy could therefore not be determined in this age group.
Wernicke's encephalopathy was found in 12.5 per cent of all alcoholics and in 0.8 per cent of all autopsies. One third of the Wernicke cases had acute and subacute lesions while two thirds were chronic. Most of the acute lesions were widespread and severe. The chronic lesions were more restricted but showed great variations in extent and severity within the affected areas. There were corresponding variations in the severity of the clinical symptoms.
Experimental models for studying the effects of ethanol on the myocardium
Authors: Regan Timothy J , Morvai Veronika 
Published: August 2010

AbstractThe ability to induce alcoholic cardiomyopathy has been tested in a variety of animal species. Myocardial alterations consistent with subclinical heart disease have been produced in many of these studies through a direct effect of ethanol or its metabolites upon the heart or a neurohumoral mechanism. In the rat most studies have, however, failed to finding diminished contractility in the basal state. In long‐term animals the acute left ventricular responses to isoproterenol and calcium as well as pacing were reduced. Long‐term studies in mongrel dogs fed 36 per cent of calories as ethanol produced an early decrease in left ventricular diastolic compliance related to interstitial collagen accumulation. Diminished contractility developed by four years. In addition to the morphologic evidence of distorted sarcoplasmic reticulum, in vitro experiments suggest important acute effects. Each mole of ethanol is bound tightly to each mole of protein comprising the Ca‐ATPase pump, which is inhibited. Impaired uptake and binding of calcium by the sarcoplasmic reticulum has been observed in chronic alcohol models at one to two day intervals following the last exposure to ethanol. In addition, the flux of calcium ion does not appear normal in terms of access to contractile protein, where the calcium regulated inhibition of the troponin interaction with myosin is impaired. Experimental studies in a canine model of alcoholism revealed that the ventricular fibrillation threshold was moderately reduced in the basal state after 18 months and was diminished further after acute exposure.
Atrial Natriuretic Peptide during Exercise in Patients with Coronary Heart Disease before and after Single Dose Atenolol and Acebutolol
Authors: KELLER NIELS , SYKULSKI ROMAN , THAMSBORG GORM , STORM TOMMY , LARSEN JOHN 
Published: August 2010

ABSTRACT.Plasma atrial natriuretic peptide (ANP) was measured during dynamic exercise in 10 patients with coronary heart disease before and after single dose atenolol 50 mg and acebutolol 200 mg, respectively. Systolic blood pressure, heart rate and the rate‐pressure product increased during exercise before and after β‐blockade, but levels were lower after β‐blockade. Plasma ANP levels at rest were unchanged after atenolol, but rose after acebutolol (p<0.01). During exercise plasma ANP increased significantly both before and after β‐blockade, but plasma ANP levels were higher after acebutolol at all workloads (p<0.05), whereas plasma ANP levels after atenolol were higher at 125 W exclusively (p<0.05). The augmented ANP levels during exercise after β‐blockade probably reflect catecholamine‐stimulated ANP release, whereas the elevated plasma ANP levels after acebutolol at rest might be a β‐adrenoceptor‐mediated ANP release due to the intrinsic sympathomimetic effect of acebutolol.
Long‐term Results in 64 Patients Operated Upon for Pheochromocytoma
Authors: STENSTRÖM GUNNAR , ERNEST INGRID , TISELL LARS‐ERIK 
Published: August 2010

ABSTRACT.During the years 1956–1982, 64 pheochromocytoma patients were operated upon without mortality. Twenty‐eight patients had sustained hypertension and 29 paroxysmal hypertension only. In two patients high blood pressure was not related to pheochromocytoma and five subjects were normotensive. In two women the pheochromocytoma demonstrated malignancy by widespread metastases. Sixteen patients also had neuroectodermal manifestations other than pheochromocytoma. Preoperatively, heart disease was found in most of the hypertensive patients aged 50 years or more at operation, but was uncommon in the others. In these subjects, heart disease persisted after surgery. Young subjects with sustained hypertension were not less affected by preoperative cerebrovascular accidents than older subjects. After surgery, hypertension persisted in 12 patients, and was easily controlled by drug therapy in eight. Nine patients died 7 months‐18 years after surgery. In no case was the death directly associated with the pheochromocytoma disease. Three died from other neuroectodermal abnormalities. The 55 surviving patients have been followed up for a mean of 12 years after surgery. During the observation time the survival of the pheochromocytoma patients was similar to that of the normal population. At the end of the study, 44 out of the 55 surviving patients were free from symptoms.
Responsiveness to Diving Reflex after Acute Myocardial Infarction: Influence of Early β‐Adrenoceptor Blocker Therapy
Authors: OLSSON GUNNAR , REHNQVIST NINA , EKMAN ANNE‐MARIE 
Published: August 2010

ABSTRACT.We studied the influence of β‐adrenoceptor blockade on heart rate responses to facial immersion in ice‐cooled water after acute myocardial infarction. Forty patients with acute myocardial infarction were randomized to the double‐blind therapy with metoprolol 200 mg daily or matching placebo. Therapy was started as soon as possible after admission to hospital and continued for 15 days. After this initial period all patients were treated with β‐blockade during the subsequent 6 months. Repeated investigations of heart rate responses to facial immersion in ice‐cooled water and 24‐hour ECG‐recordings were performed on day 15 (while patients were on study therapy), after 6 weeks, 3 and 6 months. Throughout the 6‐month period, facial immersion elicited significant heart rate reductions in both treatment groups. No differences were found between the two groups or between different examinations during follow‐up. There was no correlation between heart rate response to facial immersion and frequency of ventricular arrhythmia on a 24‐hour monitoring. In conclusion, acute administration of metoprolol in myocardial infarction does not influence the bradycardial response to facial immersion either in the early postinfarction phase or during 6 months' follow‐up. There is no relation between bradycardial response to face immersion and frequency of ventricular arrhythmias.
One or Three Weeks' Treatment of Acute Pyelonephritis?: A Double‐blind Comparison, Using a Fixed Combination of Pivampicillin Plus Pivmecillinam
Authors: JERNELIUS HANS , ZBORNIK JAN , BAUER CARL‐AXEL 
Published: August 2010

ABSTRACT.The clinical and bacteriological effects of 1 and 3 weeks' pivampicillin plus pivmecillinam treatment were compared in a double‐blind, randomized study of patients with acute pyelonephritis. Three weeks after the end of active treatment, clinical success was seen in 29 (91 %) of the 32 patients on 1‐week treatment, compared with 28 (97%) of the 29 patients treated for 3 weeks. Bacteriological success was seen in only nine (28%) patients in the 1‐week group vs. 20 (69%) in the 3‐week group (p=0.004). This difference was mainly due to a large number of relapses of lower urinary tract infection in the 1‐week group. Even in uncomplicated cases, the bacteriological result of the 1‐week treatment was unsatisfactory. Side‐effects were more common in the 3‐week treatment group. In conclusion, 1‐week treatment of patients with acute pyelonephritis is too short. Three weeks' treatment is effective in uncomplicated cases, but even longer treatment or low‐dose prophylaxis is indicated in certain patients with predisposing factors.