bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stereo-DIC Challenge 1.0 – Rigid Body Motion of a Complex Shape
Authors: Ahmad W. , Helm J. , Bossuyt S. , Reu P. , Turner D. , Luan L.K. , Lava P. , Siebert T. , Simonsen M. 
Published: May 2024

Abstract
Background
Stereo-DIC is a widely used optical measurement technique that provides a dense full-field 3D measurement of the shape, displacement, and strain of a solid sample. When compared with 2D-DIC, Stereo-DIC provides greater flexibility and expands its use beyond flat, planar specimens. Furthermore, the widespread availability of commercial systems has led to the adoption of the technique throughout industry, academia, and government research labs.

Objective
Even though some research has been done to understand the effects of different experimental and stereo-DIC parameters, no reference is available to benchmark and compare the performance of current stereo-DIC algorithms to each other.

Methods
This paper provides the description and analysis of a carefully controlled 3D experiment and associated images used to compare the results from five subset based DIC software packages. Both the images and analysis codes used in this paper to compare the results are described here and are available for download and use for continued research.

Results
We show that over a very large range of motion, the 3D errors are very small, less than 80$$\mu$$
μ
m over a travel of ±20 mm out-of-plane and ±20 mm in-plane. While all codes performed similarly, there are important differences noted in the paper.

Conclusion
The image sets and results comparison software are hosted by the International DIC Society (www.iDICs.org) and are freely available for download and analysis for comparison with results in this paper. Furthermore, it is hoped that this set of images can be used for future research in improving stereo-DIC by future authors.
Production of N-glycosylated alcohol dehydrogenase in Escherichia coli
Authors: Levarski Zdenko , Bírová Stanislava , Hriňová Kristina , Dlapová Johana , Struhárňanská Eva , Levarská Lenka , Turňa Ján , Stuchlík Stanislav 
Published: May 2024

AbstractN-glycosylation of recombinant proteins using bacterial glycosylation system has proven to be a valuable although developing tool ultimately applicable to various industries. When used for enzyme engineering, it offers the possibility of increased stability or immobilization route and thus increasing effectiveness of e.g. biotransformation or other biocatalysis procedures. One such promising enzyme is alcohol dehydrogenase (ADH) for use in redox biotransformation reactions. Given the current possibilities of recombinant enzyme production, including major advances in glycoengineering and glycoprotein production in bacterial organisms, the aim of this work was the production of thermotolerant ADH from Rhodococcus ruber (RrADH) in glycosylated form in Escherichia coli. We have successfully developed a dual plasmid expression system enabling glycosylation of target proteins utilizing a glyco-tag approach. We were able to produce RrADH in soluble form and at the same time we detected a bacterial glycan conjugated to RrADH as well as the activity of the enzyme. The glycan bound to recombinant enzyme can be used for oriented covalent immobilization of the enzyme, which would increase the potential for its practical application in biotransformation of various compounds.
The effect of occupational therapy services on hospital readmission for patients with cancer in acute care settings: a retrospective data analysis
Authors: McNichols Christine C. , Peterson Alicia K. , Reynolds Stacey 
Published: May 2024

Abstract
Purpose
This study examined how the use of occupational therapy services affected the likelihood of hospital readmission within 30 days for patients with cancer diagnoses.

Methodology
This was a retrospective observational study. Patient medical records were analyzed from a National Cancer Institute Hospital over a 5-year period with a sample size of 6614 patients included for analysis in an unadjusted logistic regression model and 1920 patients analyzed in an adjusted logistic regression model. Various factors, including the use of occupational therapy services as well as individual factors such as pain levels, cancer stage, and living environment, were considered in relation to readmission status. Logistic regression analyses were used to assess the provision of occupational therapy service’s association with 30-day hospital readmissions.

Results
Patients who received occupational therapy services had a statistically significant decrease in their risk of a 30-day hospital readmission compared to patients with cancer who did not receive occupational therapy services. In an unadjusted analysis, patients with cancer who had occupational therapy services were 33.5% (OR = 0.665) less likely to be readmitted within 30 days compared to a patient who did not have occupational therapy services (p < 0.001). In an analysis after adjusting for patient health–related factors, patients with cancer who had occupational therapy services were 22.2% (OR = 0.778) less likely to readmit to a hospital compared to a patient who did not have occupational therapy services (p < 0.046).

Conclusion
The results of the study are intended to contribute to the body of knowledge on the benefits of occupational therapy services on an individual as well as a health systems–based level for patients with cancer diagnoses while hospitalized.

Implications for Cancer Survivors
The knowledge of the utility of occupational therapy services for patients with cancer diagnoses while in the hospital can assist providers, patients, and hospital leadership in understanding some of the potential benefits for patient care and healthcare systems at large while seeking to avoid the deleterious effects from a hospital readmission.
Highlighting the role of CD44 in cervical cancer progression: immunotherapy’s potential in inhibiting metastasis and chemoresistance
Authors: de Sousa Cayleigh , Eksteen Carla , Riedemann Johann , Engelbrecht Anna-Mart 
Published: May 2024

AbstractCervical cancer affects thousands of women globally with recurring high-risk HPV infections being at the centre of cervical pathology. Oncological treatment strategies are continually challenged by both chemoresistance and metastasis within patients. Although both work hand-in-hand, targeting their individual mechanisms could prove highly beneficial for treatment outcomes. Such targets include the metastatic-promoting stem cell marker, CD44, which is abundant in cervical cancer cells and is common to both chemoresistance and metastatic mechanisms. Seeing that many existing advanced-stage cervical cancer treatment regimes, such as platinum-based chemotherapy regimens, remain limited and are rarely curative, alternative treatment options within the field of immunology are being considered. The use of immune checkpoint inhibition therapy, which targets immune checkpoints, CTLA-4 and PD-1/PD-L1, has shown promise as an alternate standard of care for patients suffering from advanced-stage cervical cancer. Therefore, this review aims to assess whether immune checkpoint inhibition can mitigate the pathological effects of CD44-induced EMT, metastasis, and chemoresistance in cervical cancer patients.
Circularly polarized light emission and detection by chiral inorganic semiconductors
Authors: Li Zha , Li Wancai , Li Dehui , Tang Wei , Liang Huageng , Song Huaibing , Chen Chao , Gao Liang , Tang Jiang 
Published: May 2024

AbstractChiral inorganic semiconductors with high dissymmetric factor are highly desirable, but it is generally difficult to induce chiral structure in inorganic semiconductors because of their structure rigidity and symmetry. In this study, we introduced chiral ZnO film as hard template to transfer chirality to CsPbBr3 film and PbS quantum dots (QDs) for circularly polarized light (CPL) emission and detection, respectively. The prepared CsPbBr3/ZnO thin film exhibited CPL emission at 520 nm and the PbS QDs/ZnO film realized CPL detection at 780 nm, featuring high dissymmetric factor up to around 0.4. The electron transition based mechanism is responsible for chirality transfer.
Graphical Abstract
Identification and validation of a prognostic signature based on six immune-related genes for colorectal cancer
Authors: Zheng Lifeng , Xu Ziyu , Zhang Wulou , Lin Hao , Zhang Yepeng , Zhou Shu , Liu Zonghang , Gu Xi 
Published: May 2024

Abstract
Background
Colorectal cancer (CRC) is a prevalent malignancy with high mortality and morbidity rates. Although the significant efficacy of immunotherapy is well established, it is only beneficial for a limited number of individuals with CRC.

Methods
Differentially expressed immune-related genes (DE-IRGs) were retrieved from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and ImmPort databases. A prognostic signature comprising DE-IRGs was developed using univariate, LASSO, and multivariate Cox regression analyses. A nomogram integrating the independent prognostic factors was also developed. CIBERSORT was used to assess immune cell infiltration (ICI). Furthermore, wound-healing, colony formation, migration, and invasion assays were performed to study the involvement of ACTG1 in CRC.

Results
A signature including six DE-IRGs was developed. The overall survival (OS) rate was accurately estimated for TCGA and GSE38832 cohorts. The risk score (RS) of the signature was an independent factor for OS. Moreover, a nomogram encompassing age, RS, and pathological T stage accurately predicted the long-term OS probability of individuals with CRC. The high-risk group had an elevated proportion of patients treated with ICIs, including native B cells, relative to the low-risk group. Additionally, ACTG1 expression was upregulated, which supported the proliferation, migration, and invasion abilities of CRC cells.

Conclusions
An immune-related prognostic signature was developed for predicting OS and for determining the immune status of individuals with CRC. The present study provides new insights into accurate immunotherapy for individuals with CRC. Moreover, ACTG1 may serve as a new immune biomarker.
A rare case report: multiple intrahepatic masses in a pediatric patient with citrin deficiency
Authors: Lin Hui , Jiang Hong , Chen Qiang , Pan Xiang , Deng Mei , Cai Xiang-Ran , Lu Yuan-Zhi , Song Yuan-Zong , Liu Jun-Cheng 
Published: May 2024

AbstractDeficiency of citrin, the liver-type aspartate-glutamate carrier, arises from biallelic mutations of the gene SLC25A13. Although citrin deficiency (CD) is associated with higher risk of hepatocellular carcinoma (HCC) in adult patients, this association remains inconclusive in pediatric cases. The patient in this paper had been diagnosed to have CD by SLC25A13 analysis at the age 10 months, and then in response to dietary therapy, her prolonged jaundice and marked hepatosplenomegaly resolved gradually. However, she was referred to the hospital once again due to recurrent abdominal distention for 2 weeks at her age 4 years and 9 months, when prominently enlarged liver and spleen were palpated, along with a strikingly elevated serum alpha-fetoprotein (AFP) level of 27605 ng/mL as well as a large mass in the right liver lobe and a suspected tumor thrombus within the portal vein on enhanced computed tomography. After 4 rounds of adjuvant chemotherapy, right hepatic lobectomy and portal venous embolectomy were performed at her age 5 years and 3 months, and metastatic hepatoblastoma was confirmed by histopathological analysis. Afterwards, the patient underwent 5 additional cycles of chemotherapy and her condition remained stable for 7 months after surgery. Unfortunately, hepatoblastoma recurred in the left lobe at the age 5 years and 10 months, which progressed rapidly into liver failure, and led to death at the age 6 years and 1 month. As far as we know, this is the the first case of hepatoblastoma in a patient with CD, raising the possibility of an association between these two conditions.
Foraging behavior and the nest architecture of a high-Andean stingless bee (Hymenoptera: Apidae: Meliponini) revealed by X-ray computerized tomography
Authors: Jacome-García Jesus C. , Gonzalez Victor H. , Riaño-Jimenez Diego A. , Herrera-Motta Andres F. , Cure Jose R. 
Published: May 2024

AbstractStingless bees (Hymenoptera: Apidae: Meliponini) are key pollinators of both cultivated and wild plants in tropical and subtropical areas of the world. While most species are found in lowland to mid-elevations, a few have adapted to high elevations, and their biology remains poorly understood. We assess the foraging pattern of Parapartamona zonata (Smith) in the central Andes of Colombia (2583 m.a.s.l.) and apply computer tomography to visualize and characterize its internal nest architecture. Bees foraged for pollen and nesting materials (resin and/or mud) from sunrise (5:40 h) to sunset (17:45), even at ambient temperatures as low as 11 °C. Foraging varied significantly throughout the day and temperature and sky condition explained 47% of its variance. Differences in the nest architecture, when compared with previous records, suggest that nesting behavior might be variable. These results are discussed in the context of behavioral adaptations in this unique environmental niche.
Nondestructive and active interrogation system for special nuclear material: proof of principle and initial results
Authors: Bakr Mahmoud , Masuda Kai , Takahashi Yoshiyuki , Misawa Tsuyoshi , Yamakawa Norio , Scott Tomas 
Published: May 2024

AbstractHerein, we employ the threshold energy neutron analysis (TENA) technique to introduce the world's first active interrogation system to detect special nuclear materials (SNMs), including U-235 and Pu-239. The system utilizes a DD neutron generator based on inertial electrostatic confinement (IEC) to interrogate suspicious objects. To detect secondary neutrons produced during fission reactions induced in SNMs, a tensioned metastable fluid detector (TMFD) is employed. The current status of the system's development is reported in this paper, accompanied by the results from experiments conducted to detect 10 g of highly enriched uranium (HEU). Notably, the experimental findings demonstrate a distinct difference in the count rates of measurements with and without HEU. This difference in count rates surpasses two times the standard deviation, indicating a confidence level of more than 96% for identifying the presence of HEU. The paper presents and extensively discusses the proof-of-principle experimental results, along with the system's planned trajectory.
Applications of microfluidics in biosensing
Authors: Sekhwama Masindi , Mpofu Kelvin , Sivarasu Sudesh , Mthunzi-Kufa Patience 
Published: May 2024

AbstractMicrofluidic devices have become a vastly popular technology, particularly because of the advantages they offer over their traditional counterparts. They have such a wide range of uses and can make complex tasks quite efficient. One area of research or work that has benefited greatly from the use of microfluidics is biosensing, where microfluidic chips are integrated into biosensor setups. There are growing numbers of applications of microfluidics in this area as researchers look for efficient ways to tackle disease diagnostics and drug discovery, which are critical in this era of recurring pandemics. In this work, the authors review the integration of microfluidic chips with biosensors, as well as microfluidic applications in biosensing, food security, molecular biology, cell diagnostics, and disease diagnostics, and look at some of the most recent research work in these areas. The work covers a wide range of applications including cellular diagnostics, life science research, agro-food processing, immunological diagnostics, molecular diagnostics, and veterinarian diagnostics. Microfluidics is a field which combines fundamental laws of physics and chemistry to solve miniaturization problems involving fluids at the nanoscale and microscale, and as such, the authors also examine some fundamental mathematical concepts in microfluidics and their applications to biosensing. Microfluidics has relatively new technologies with great potential in terms of applications.
The Concept of the Rule of Law and Global Economic Governance: Theoretical Remarks
Authors: Culot Henri 
Published: May 2024

AbstractThis article offers some general thoughts on the rule of law in international economic law. It begins by briefly defining the rule of law and indicating the legal sources on which it is based. It then shows that the TFEU, confirmed by the case law of the Court of Justice, requires the rule of law to be respected in the conduct of the Union’s commercial policy. However, although the rule of law may be favourable to international trade and investment, it is not indispensable to them. The rule of law is conducive, but not essential, to trade and investment. For businesses, the risks associated with a weak respect for the rule of law represent a cost, which they take into account when setting the price of their products. Finally, it should be remembered that the principles of the rule of law do not apply in the same way in the domestic sphere as in international law. This article is intended as a panoramic introduction to the relationship between the rule of law and international economic law. More specialised studies are published later in this issue, including analyses focusing on trade or investment or national perspectives, such as that of China.
Lowering the Age of Consent for Vaccination to Promote Pediatric Vaccination: It’s Worth a Shot
Authors: Irwin Margaret , Soled Derek R. , Cummings Christy L. 
Published: May 2024

AbstractThis paper challenges historically preconceived notions surrounding a minor’s ability to make medical decisions, arguing that federal health law should be reformed to allow minors with capacity as young as age 12 to consent to their own Centers for Diseases Control and Prevention (CDC)-approved COVID-19 vaccinations. This proposal aligns with and expands upon current exceptions to limitations on adolescent decision-making. This analysis reviews the historic and current anti-vaccination sentiment, examines legal precedence and rationale, outlines supporting ethical arguments regarding adolescent decision-making, and offers rebuttals to anticipated ethical counterarguments.
Diverting Data and Drugs: A Narrative Review of the Mallinckrodt Documents
Authors: Lentacker Antoine , Pham Kelly , Chernesky Jason M. 
Published: May 2024

AbstractU.S. law imposes strict recording and reporting requirements on all entities that manufacture and distribute controlled substances. As a result, the prescription opioid crisis has unfolded in a data-saturated environment. This article asks why the systematic documentation of opioid transactions failed to prevent or mitigate the crisis. Drawing on a recently disclosed trove of 1.4 million internal records from Mallinckrodt Pharmaceuticals, a leading manufacturer of prescription opioids, we highlight a phenomenon we propose to call data diversion, whereby data ostensibly generated or collected for the purpose of regulating the distribution of controlled substances were repurposed by the industry for the opposite aim of increasing sales at all costs. Systematic data diversion, we argue, contributed substantially to the scale of drug diversion seen with opioids and should become a focus of policy intervention.
Beyond stomatal development: SMF transcription factors as versatile toolkits for land plant evolution
Authors: Doll Yuki , Koga Hiroyuki , Tsukaya Hirokazu 
Published: May 2024

Abstract
As master transcription factors of stomatal development, SPEECHLESS, MUTE, and FAMA, collectively termed SMFs, are primary targets of molecular genetic analyses in the model plant Arabidopsis thaliana. Studies in other model systems identified SMF orthologs as key players in evolutionary developmental biology studies on stomata. However, recent studies on the astomatous liverwort Marchantia polymorpha revealed that the functions of these genes are not limited to the stomatal development, but extend to other types of tissues, namely sporophytic setal and gametophytic epidermal tissues. These studies provide insightful examples of gene-regulatory network co-opting, and highlight SMFs and related transcription factors as general toolkits for novel trait evolution in land plant lineages. Here, we critically review recent literature on the SMF-like gene in M. polymorpha and discuss their implications for plant evolutionary biology.
Barriers and facilitators to health-care access by older Chinese migrants in high-income countries: a mixed-methods systematic review
Authors: Guo Haoyue , AlSwayied Ghada , Frost Rachael , Rait Greta , Burns Fiona 
Published: May 2024

Abstract
International migrants face barriers when accessing health-care in their destination countries. For older migrants, there are additional difficulties due to their age and associated health conditions. Chinese migrants are an understudied group with culture-specific barriers in addition to those shared with other migrant groups. This review aims to understand the barriers and facilitators to health-care access faced by older Chinese migrants in high-income countries. Literature from MEDLINE, Web of Science, EMBASE, Scopus, CINAHL Plus and ProQuest (1 January 2000 to 6 October 2021) were retrieved. Quantitative, qualitative and mixed-methods studies focusing on older Chinese migrants' access to, utilisation of and satisfaction with health-care services in high-income countries were included. Studies were appraised using checklists from the Joanna Briggs Institute and the Critical Appraisal Skills Programme. Qualitative and quantitative data were extracted and analysed narratively to identify barriers and facilitators to accessing health-care, then applied to Levesque's five-step health-care access journey framework. We included 33 studies in the analysis. Qualitative evidence identified barriers and facilitators to health-care access in four categories: health-care system, social factors, personal factors and health-care interactions. Quantitative studies found that health status and having insurance were positively associated with using non-preventive care, while time of residence and physician's recommendations were positively associated with using preventive care. Factors that influence older Chinese migrants' access to health care include practical barriers (communication, time and cost), social support (family and community), perceptions of health and care needs (beliefs and knowledge) and interactions with health-care professionals (patient–physician trust and support from physicians). Efforts to overcome universal barriers, acknowledgement of cultural contexts, improvements in translation services, and involvement of Chinese families and communities in health-care outreach will benefit this population.