bluuebunny/crossref_metadata_2025_split huggingface dataset:
MS-GWaM: A Three-Dimensional Transient Gravity Wave Parametrization for Atmospheric Models
Authors: Voelker Georg S. , Bölöni Gergely , Kim Young-Ha , Zängl Günther , Achatz Ulrich 
Published: April 2024

Abstract
Parameterizations for internal gravity waves in atmospheric models are traditionally subject to a number of simplifications. Most notably, they rely on both neglecting wave propagation and advection in the horizontal direction (single-column assumption) and an instantaneous balance in the vertical direction (steady-state assumption). While these simplifications are well justified to cover some essential dynamic effects and keep the computational effort small, it has been shown that both mechanisms are potentially significant. In particular, the recently introduced Multiscale Gravity Wave Model (MS-GWaM) successfully applied ray-tracing methods in a novel type of transient but columnar internal gravity wave parameterization (MS-GWaM-1D). We extend this concept to a three-dimensional version of the parameterization (MS-GWaM-3D) to simulate subgrid-scale nonorographic internal gravity waves. The resulting global wave model—implemented into the weather forecast and climate code Icosahedral Nonhydrostatic (ICON)—contains three-dimensional transient propagation with accurate flux calculations, a latitude-dependent background source, and convectively generated waves. MS-GWaM-3D helps reproduce expected temperature and wind patterns in the mesopause region in the climatological zonal mean state and thus proves a viable internal gravity wave (IGW) parameterization. Analyzing the global wave action budget, we find that horizontal wave propagation is as important as vertical wave propagation. The corresponding wave refraction includes previously missing but well-known effects such as wave refraction into the polar jet streams. On a global scale, three-dimensional wave refraction leads to a horizontal flow-dependent redistribution of waves such that the structures of the zonal mean wave drag and consequently the zonal mean winds are modified.
An Analysis of K–12 Climate Change Science Standards in the United States
Authors: Beaver Breanna C. , Navy Shannon L. , Heisler Jennifer L. 
Published: April 2024

Abstract
To produce a climate-literate society willing to take action, students must be educated on the causes, changes, impacts, and solutions of climate change. One way to ensure students are educated on climate change is to have robust science standards. However, little is known about the collective climate change standards in the United States. Therefore, the purpose of this study is to conduct an analysis of the U.S. K–12 science standards to uncover where the climate change standards are located in different grade levels and the extent to which the collective U.S. curriculum covers topics of climate change. This study was a qualitative content analysis of the U.S. K–12 climate change standards. The results show that most U.S. climate change standards are found within the high school grade levels and Earth and space science domains. All U.S. states address topics of climate change within their standards; however, general mentions of climate change were cited most often. Finally, the majority of states address both natural and anthropogenic causes of climate change. Implications for policymakers and educators are included.
Programme de soins psychiatriques : Etude de l’expérience de jeunes patients par une méthode qualitative: Psychiatric care program: A qualitative study of the experience of young patients
Authors: Jiguet Sarah , Michel Thibault , Capdevielle Delphine 
Published: April 2024

RésuméObjectifLes dispositifs de soins ambulatoires sans consentement sont largement utilisés, mais ils sont controversés et leur efficacité n’est pas prouvée à ce jour. L’expérience des patients concernés reste très peu étudiée en France, et notamment celui des jeunes patients, or leur adhésion aux soins en début de maladie est complexe et a un impact sur le pronostic futur. L’objectif est d’étudier l’expérience de jeunes patients suivis en programme de soins (PDS) afin de proposer des perspectives pour optimiser leur prise en charge et d’enrichir la réflexion sur l’utilisation des PDS.MéthodeDes entretiens semi-directifs ont été réalisés auprès de 11 patients de 20 à 32 ans suivis en PDS ou l’ayant été dans les 5 dernières années, puis une analyse phénoménologique de type sémio-pragmatique a été réalisée sur les verbatims obtenus.Résultats(1) L’expérience de la contrainte en ambulatoire est contrastée avec un vécu de privation de libertés et d’intrusion, mais aussi de soutien et de protection. (2) Le PDS est représenté comme un cadre permettant l’évolution de la conscience des troubles et de l’acceptation des soins. (3) Les patients rapportent un manque d’information sur les modalités de soins sous contrainte, pouvant aller jusqu’à la méconnaissance de l’existence de cette mesure. Les interactions patient-psychiatre au sein du PDS sont complexifiées par la contrainte mais restent perçues comme une relation de soin. (4) Ils rapportent des contraintes dans la vie quotidienne liées au PDS et qui peuvent compliquer l’insertion professionnelle.ConclusionLes résultats soutiennent l’importance de soigner la relation thérapeutique au sein du PDS et d’impliquer davantage le patient dans sa prise en charge, en commençant par une meilleure information. Ils soutiennent une utilisation du PDS comme un outil temporaire à associer à un travail sur l’adhésion aux soins et à un accompagnement à la réinsertion sociale et professionnelle.SpécialitéPsychiatrie
Psychiatrists can save lives with naloxone
Authors: Branchflower Antigone , Lundin Robert M , Harvey Craig , Hill Harry 
Published: April 2024

Objectives Naloxone is an effective medication used to reverse opioid overdoses. Distributing naloxone directly to those at risk, therefore, reduces the risk of opioid-related deaths. New legislation in Australia means a prescription is no longer required to access naloxone. Whilst acknowledging the benefits of increased access, we aim to evaluate the impact psychiatrists can have on naloxone provision due to their unique position as doctors often working with those who may be at risk. Methods Data was recorded on those accessing naloxone from a co-located addiction and mental health service. Descriptive statistics were generated to establish the cohort characteristics, prior knowledge of naloxone and outcome of previously supplied naloxone. Results Naloxone was dispensed 488 times from 2021 to 2023. 267 people had previously been prescribed naloxone from these sites where 137 (51.3%) were reportedly used in an opioid reversal. Conclusions Our findings highlight the importance of community access to naloxone in reducing opioid-related harm. Whilst removing the need for a prescription makes naloxone more accessible, it remains vital that doctors remain involved in this process to broaden the reach of supply to those at risk.
The “Bundle Wire” Technique: A Novel Approach to Cannulating Challenging Target Vessels Using Multiple Fine Atraumatic Guidewires That Together Serve as a Stiff Guidewire
Authors: Ali Ahmed A. , Stana Jan , Bruno Salvatore , Joseph George , Eleshra Ahmed , Tsilimparis Nikolaos 
Published: April 2024

Purpose: To present a novel technique that enables safe and effective cannulation of target vessels with challenging anatomy during fenestrated/branched endovascular aortic repair (F/B-EVAR). Technique: Following deployment of the F/B-EVAR endograft, the target vessels (TVs) are cannulated. The bundle wire technique provides a solution to challenging TVs and uses multiple fine atraumatic guidewires that together serve as a stiff guidewire. The technique can be executed in 2 ways using: (1) one 0.018 inch and one 0.014 inch guidewire or (2) three 0.014 inch guidewires. We demonstrate the technique in a case of a complex abdominal aortic aneurysm treated using branched EVAR in which the left renal artery with severe ostial stenosis was catheterized using the bundle wire technique. Conclusions: The bundle wire technique offers a technically feasible and economically viable solution for facilitating catheter and bridging stent delivery in anatomically challenging TVs during F/B-EVAR. It is a useful addition to the therapeutic armamentarium available to physicians for accessing demanding TVs.
The ‘demographic winter’ in Italy: Crisis factors, problematic issues and policy actions
Authors: Blangiardo Gian Carlo 
Published: April 2024

Demographic issues are becoming key to the debate on the future of Europe, and of Italy in particular, which has the lowest birth rate in Europe but is among the top-ranked countries for demographic ageing. The general improvement of living conditions and the ageing of large cohorts cannot be supported by the economic activity of the younger generations, which calls into question the security of certain aspects of the social pact, such as the provision of pensions and health care. While encouraging an awareness among Italians of the trends and problems they will have to deal with, all national actors must cooperate to ensure the recovery of the birth rate, and to harness the economic benefits of incoming migrants and the experiences of older people. It is equally necessary to meet the needs of young people and enhance their social role. Only through such cooperation will it be possible to create a favourable climate for actions that will allow us to control and direct these demographic phenomena and not to suffer from them.
Behavioral Therapy for People With Diabetes Who Smoke: A Scoping Review
Authors: Sammut Roberta , Grech Joseph , Polosa Riccardo , Campagna Davide , Di Ciaula Agostino , Dugal Tabinda , Kenge Andre , Misra Anoop , Abbas Raza Syed , Russo Cristina , Somasundaram Noel , Walicka Magdalena , Phoung Le Dinh , Prezzavento Graziella Chiara , Casu Mirko , La Rosa Giusy Rita Maria , Caponnetto Pasquale 
Published: April 2024

Background: Tobacco smoking exacerbates diabetes-related complications; its prevalence is notwithstanding substantial. Persons with diabetes face a number of barriers and challenges to quitting such as multiple lifestyle restrictions; tailored interventions are required for smoking cessation. Objective: To identify research on behavioral interventions for smoking cessation in diabetes. Methods: Studies had to be randomized controlled trials, quasiexperimental or systematic reviews. The behavioral interventions included were: the 5As, Cognitive-Behavioral Therapy, Motivational Interviewing, Contingency Management, Health Coaching and Counselling, as compared to standard care. The outcomes were self-reported and/or biochemically verified smoking cessation. CINAHL Complete, MEDLINE Complete, the Cochrane databases of systematic reviews and randomized controlled trials, PsychInfo and PubMed Central were searched until July, 2023. Keywords used included diabetes, smoking cessation and each of the behavioral interventions included. Results: 1615 papers were identified. Three studies on the 5As/brief advice, 4 on Motivational Intervention and 1 on counseling were retained. The results on the 5As and Motivational Interviewing were conflicting. More intensive interventions appear to be more successful in achieving smoking cessation in smokers with diabetes. Conclusions: Future research should focus on the continued development and evaluation of structured smoking cessation interventions based on the 5As, Motivational interviewing and Cognitive Behavioral Therapy.
Escalation on Kihon Checklist Scores Preceding the Certification of Long-Term Care Need in the Older Population in Japan. A 9-Year Retrospective Study
Authors: Kitazawa Kazuki , Tsuchiya Kenji , Hirao Kazuki , Furukawa Tomomi , Tozato Fusae , Iwaya Tsutomu , Mitsui Shinichi 
Published: April 2024

Objectives The Kihon Checklist (KCL) is valuable for predicting long-term care (LTC) certification. However, the precise association between KCL scores and the temporal dynamics of LTC need certification remains unclear. This study clarified the characteristic trajectory of KCL scores in individuals certified for LTC need. Methods The KCL scores spanning from 2011 to 2019 were obtained from 5630 older individuals, including those certified for LTC need in November 2020, in Iiyama City, Nagano, Japan. We analyzed the KCL score trajectories using a linear mixed model, both before and after propensity score matching. Results Throughout the 9-year observation period, the KCL scores consistently remained higher in the certified group compared to the non-certified group. Notably, a significant score increase occurred within the 3 years preceding LTC certification. Discussion Our findings highlight the effectiveness of continuous surveillance using the KCL in identifying individuals likely to require LTC within a few years.
Regional Inequalities in Oral Frailty and Social Capital
Authors: Yamamoto T. , Mochida Y. , Irie K. , Altanbagana N. U. , Fuchida S. , Aida J. , Takeuchi K. , Fujita M. , Kondo K. 
Published: April 2024

Introduction: Oral frailty leads to poor nutritional status, which, in turn, leads to frailty. This cross-sectional study aimed to determine regional differences in the prevalence of oral frailty and to identify factors associated with oral frailty using 3-level multilevel models. Methods: This study comprised 165,164 participants aged ≥65 y without long-term care requirements in the Japan Gerontological Evaluation Study. The dependent variable was oral frailty, which was calculated based on age, number of teeth, difficulty in eating tough foods, and choking. The individual-level independent variables included sociodemographics, present illness, social participation, frequency of meeting friends, and social capital. The local district-level independent variable was social capital (n = 1,008) derived from exploratory factor analyses. The municipality-level independent variable was population density (n = 62). Three-level multilevel Poisson regression analysis was performed to calculate the prevalence ratios (PRs). Results: The prevalence of oral frailty in municipalities ranged from 39.9% to 77.6%. Regarding district-level factors, higher civic participation was significantly associated with a lower probability of oral frailty. At the municipality level, the PR of the rural-agricultural area was 1.17 (95% confidence interval, 1.11–1.23) (reference: metropolitan). Conclusion: These results highlight the usefulness of oral frailty prevention measures in encouraging social participation in rural areas. Knowledge Transfer Statement: The results of the present study showed regional differences in oral frailty. In particular, rural-agricultural areas show higher prevalence rates of oral frailty than those in metropolitan cities. Promoting measures of social participation among older adults may help prevent oral frailty in rural areas.
Compressed earthen blocks using alluvial clays from Mbam: performance comparison using statistical analysis of cement vs heat-stabilized blocks
Authors: Enock Embom Christophe , Nyemb Bayamack Joël Fabrice , Ngo'o Ze Arnaud , Mache Jacques Richard , Mbey Jean Aimé , Onana Vincent Laurent 
Published: April 2024

AbstractIn the present study, a comparison of the thermal-insulation and mechanical performances of cement and heat-stabilized compressed earthen blocks (CEBs) was carried out to determine the factors which influence those properties. The raw clays used consist mainly of kaolinite, orthoclase and quartz. The mechanical strength increased with increase in both the amount of cement added and the firing temperature. However, the responses are better for cement-stabilized CEBs. The thermal insulation of fired bricks is greater than that of cement-stabilized bricks. This difference was related to the decrease in porosity and the formation of continuous-surface. The decrease in thermal insulation is mainly related to the formation of continuous-surface in cement-stabilized CEBs, whereas in the fired CEBs, it is due to the modification of pore volume. The mineralogy of the raw clays is statistically correlated to porosity and continuous-surface development that were confirmed as the main factors in the modification of both the mechanical strength and the thermal insulation. In cement-stabilization, the decrease in insulation is due to the development of continuous surface, while for heat-stabilization, mineral transformations during the sintering reduced continuous-surface formation and the insulation was controlled by both radiation and reduced surface conduction. The influence of the mineralogy of the raw material shows that clay content favours the insulation in fired bricks obtained at T ≤ 1000°C, while sand contents favour densification. In contrast, clay contents reduce the mechanical response of cement-stabilized material due to limited cement–clay interactions. In general, the mechanical response is more favourable in cement stabilization, while thermal insulation is better in fired bricks.
An unexpected case of tetanus in a fully immunized 20-year-old female: a case report
Authors: Okuda Mitsutoshi , Morizane Atsushi , Asaba Sunao , Tsurui Saika , Tsuno Ryutaro , Hatakenaka Mariko , Sugimura Tomoko , Saisaka Yuichi 
Published: April 2024

Abstract
Background
Widespread vaccinations have significantly decreased the number of tetanus cases in developed countries. Today, most cases of tetanus affect the elderly and those with inadequate immunization in developed countries such as Japan. As vaccinations were believed to be nearly 100% effective in preventing tetanus, tetanus in young, immunized individuals were considered unlikely. However, unexpected tetanus infection has been reported in young adequately immunized individuals.

Case
We herein describe a 20-year-old immunized female who visited our emergency department with trismus and painful muscle spasms that started after receiving a puncture wound to her right foot. A physical examination revealed an elevated body temperature (38°C), trismus, muscle spasms in her right leg and neck, and a puncture wound at the sole of her right foot. Following the development of dyspnea after admission to the intensive care unit, the patient was intubated and mechanically ventilated. She fully recovered after six days in intensive care.

Conclusion
The present case serves as a stark reminder that tetanus may still occur in young, immunized individuals. Patients with a history of immunization may have a better prognosis than those with no immunizations.
Constructed Rice Tracers Identify the Major Virulent Transcription Activator-Like Effectors of the Bacterial Leaf Blight Pathogen
Authors: Liu Linlin , Li Ying , Wang Qi , Xu Xiameng , Yan Jiali , Wang Yong , Wang Yijie , Shah Syed Mashab Ali , Peng Yongzheng , Zhu Zhangfei , Xu Zhengyin , Chen Gongyou 
Published: April 2024

AbstractXanthomonas oryzae pv. oryzae (Xoo) injects major transcription activator-like effectors (TALEs) into plant cells to activate susceptibility (S) genes for promoting bacterial leaf blight in rice. Numerous resistance (R) genes have been used to construct differential cultivars of rice to identify races of Xoo, but the S genes were rarely considered. Different edited lines of rice cv. Kitaake were constructed using CRISPR/Cas9 gene-editing, including single, double and triple edits in the effector-binding elements (EBEs) located in the promoters of rice S genes OsSWEET11a, OsSWEET13 and OsSWEET14. The near-isogenic lines (NILs) were used as tracers to detect major TALEs (PthXo1, PthXo2, PthXo3 and their variants) in 50 Xoo strains. The pathotypes produced on the tracers determined six major TALE types in the 50 Xoo strains. The presence of the major TALEs in Xoo strains was consistent with the expression of S genes in the tracers, and it was also by known genome sequences. The EBE editing had little effect on agronomic traits, which was conducive to balancing yield and resistance. The rice-tracers generated here provide a valuable tool to track major TALEs of Xoo in Asia which then shows what rice cultivars are needed to combat Xoo in the field.
Assessment of neuropathic pain management knowledge, attitudes, and practices among urology trainees and consultants in prostate cancer care: a survey-based study
Authors: Sinkila O. , Matjomane N. , Cronje T. , Mathabe K. 
Published: April 2024

Abstract
Background
Effective neuropathic pain management is crucial in improving the quality of life for patients with prostate cancer. There is an abundance of research about cancer pain and guidelines that have been developed by World Health Organization including the analgesia stepladder, yet patients with cancer pain are still sub optimally analgesed. This is due to a variety of both patient and physician factors which include: lack of knowledge on the use of adjuvant medication, fear of addiction and poor characterization of the type of pain. This study intended to assess the knowledge, attitudes, and practices of urology trainees and consultants in the the context of neuropathic pain in prostatecancer care.

Methods
The study involved 91 urologists, comprising of junior registrars, medical officers and experienced specialists who are members of the South African Urological Association (SAUA). Data was collected through a 25-question web-based survey. The survey covered: demographic information, knowledge, attitudes, and practices related to cancer pain management.

Results
The study revealed that a significant proportion of urologists assessed neuropathic pain reactively, with only 8% of respondents being familiar with screening scales. Approximately, one-third preferred referrals, and 74% expressed confidence in self-treatment. Concerns regarding opioid prescription were observed in 40.4% of respondents. Furthermore, the usage of adjuvant medications was limited, with only 35% proficiently combining analgesia and adjuvants. Notably, 65% continued to escalate analgesic monotherapy.

Conclusion
Effective neuropathic pain management in prostate cancer care necessitates a multidisciplinary approach, comprehensive assessment and expertise in adjuvant medication usage. The discrepancies observed among urologists are likely due to variations in experience levels. The study identifies knowledge gaps and suboptimal practices in neuropathic pain management among urologists. Addressing these issues through education, awareness, and interdisciplinary collaboration is imperative to enhance patient outcomes and improve the quality of life for individuals with prostate cancer. This study underscores the need for improved education and interdisciplinary collaboration among urologists in managing neuropathic pain among prostate cancer patients. Enhancing these aspects is essential to achieve better patient outcomes and overall quality of life.
PPanG: a precision pangenome browser enabling nucleotide-level analysis of genomic variations in individual genomes and their graph-based pangenome
Authors: Liu Mingwei , Zhang Fan , Lu Huimin , Xue Hongzhang , Dong Xiaorui , Li Zhikang , Xu Jianlong , Wang Wensheng , Wei Chaochun 
Published: April 2024

AbstractGraph-based pangenome is gaining more popularity than linear pangenome because it stores more comprehensive information of variations. However, traditional linear genome browser has its own advantages, especially the tremendous resources accumulated historically. With the fast-growing number of individual genomes and their annotations available, the demand for a genome browser to visualize genome annotation for many individuals together with a graph-based pangenome is getting higher and higher. Here we report a new pangenome browser PPanG, a precise pangenome browser enabling nucleotide-level comparison of individual genome annotations together with a graph-based pangenome. Nine rice genomes with annotations were provided by default as potential references, and any individual genome can be selected as the reference. Our pangenome browser provides unprecedented insights on genome variations at different levels from base to gene, and reveals how the structures of a gene could differ for individuals. PPanG can be applied to any species with multiple individual genomes available and it is available at https://cgm.sjtu.edu.cn/PPanG.