bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tough, Waterproofing, and Sustainable Bio‐Adhesive Inspired by the Dragonfly Wing
Authors: Zhou Ying , Luo Jing , Jing Qiumei , Ge Shengbo , Chen Sherry , Guo Zhanhu , Li Jianzhang , Liu Zixiao , He Ping , He Ximin , Xu Ben Bin 
Published: May 2024

AbstractThe development of multifunctional bio‐adhesive plays a critical role in achieving a sustainable society, where the intrinsic sensitivity to water and poor dynamics severely bottlenecks its scale‐up application. Inspired by the microstructure of dragonfly wings, a strong and tough adhesive with excellent reprocessability is designed and developed by creating a dynamic network consisting of a lignin polyurea (LPU) framework with soybean protein (SP). The LPU framework act as the rigid nervures to slow crack propagation and transfer stress, while the SP dissipate the strain energy through the interplay from the graded hydrogen and imine bonds generated between LPU and SP. The bio‐adhesive achieves significant enhancements in fracture toughness and water resistance by ≈7 and 23 folds, respectively, compared with SP. Furthermore, the capacity for diffusion and restoration of dynamic network endows the adhesive with superior reprocessability, enabling recycled particleboard to achieve high retention of modules (over 80%). This sustainable bio‐adhesive approach offers a promising eco‐friendly alternative to the conventional petrochemical adhesive.
Targeting HIF‐1α with Specific DNA Yokes for Effective Anticancer Therapy
Authors: Zhang Ying , Wu Bing , Liu Danqing , Chen Yue , Xu Yanfang , Fu Lengxi , Lin Zhenyu , Wu Gui , Huang Fei 
Published: May 2024

AbstractHypoxia, a ubiquitous hallmark in cancer, underscores the significance of targeting HIF‐1α, the principal transcriptional factor of hypoxic responses, for effective cancer therapy. Herein, DNA yokes, a novel class of DNA nanomaterials harboring specific HIF‐1α binding sequences (hypoxia response elements, HREs), are introduced as nanopharmaceuticals for cancer treatment. Comprising a basal tetrahedral DNA nanostructure and four HRE‐bearing overhanging chains, DNA yokes exhibit exceptional stability and prolonged intracellular retention. The investigation reveals their capacity to bind HIF‐1α, thereby disrupting its interaction with the downstream genomic DNAs and impeding transcriptional activity. Moreover, DNA yokes facilitate HIF‐1α degradation via the ubiquitination pathway, thereby sequestering it from downstream targets and ultimately promoting its degradation. In addition, DNA yokes attenuate cancer cell proliferation, migration, and invasion under hypoxic conditions, while also displaying preferential accumulation within tumors, thereby inhibiting tumor growth and metastasis in vivo. This study pioneers a novel approach to cancer therapy through the development of DNA‐based drugs characterized by high stability and low toxicity to normal cells, positioning DNA yokes as promising candidates for cancer treatment.
Efficient Large‐Area (81 cm2) Ternary Copper Halides Light‐Emitting Diodes with External Quantum Efficiency Exceeding 13% via Host‐Guest Strategy
Authors: Lin Shuailing , Ma Zhuangzhuang , Ji Xinzhen , Zhou Qicong , Chu Weihong , Zhang Jibin , Liu Ying , Han Yanbing , Lian Linyuan , Jia Mochen , Chen Xu , Wu Di , Li Xinjian , Zhang Yu , Shan Chongxin , Shi Zhifeng 
Published: May 2024

AbstractTernary copper (Cu) halides are promising candidates for replacing toxic lead halides in the field of perovskite light‐emitting diodes (LEDs) toward practical applications. However, the electroluminescent performance of Cu halide‐based LEDs remains a great challenge due to the presence of serious nonradiative recombination and inefficient charge transport in Cu halide emitters. Here, the rational design of host‐guest [dppb]2Cu2I2 (dppb denotes 1,2‐bis[diphenylphosphino]benzene) emitters and its utility in fabricating efficient Cu halide‐based green LEDs that show a high external quantum efficiency (EQE) of 13.39% are reported. The host‐guest [dppb]2Cu2I2 emitters with mCP (1,3‐bis(N‐carbazolyl)benzene) host demonstrate a significant improvement of carrier radiative recombination efficiency, with the photoluminescence quantum yield increased by nearly ten times, which is rooted in the efficient energy transfer and type‐I energy level alignment between [dppb]2Cu2I2 and mCP. Moreover, the charge‐transporting mCP host can raise the carrier mobility of [dppb]2Cu2I2 films, thereby enhancing the charge transport and recombination. More importantly, this strategy enables a large‐area prototype LED with a record‐breaking area up to 81 cm2, along with a decent EQE of 10.02% and uniform luminance. It is believed these results represent an encouraging stepping stone to bring Cu halide‐based LEDs from the laboratory toward commercial lighting and display panels.
Solar‐Driven Conversion of CO2 to C2 Products by the 3d Transition Metal Intercalates of Layered Lead Iodides
Authors: Yin Jinlin , Li Dongyang , Sun Chen , Jiang Yilin , Li Yukong , Fei Honghan 
Published: May 2024

AbstractPhotocatalytic CO2 reduction to high‐value‐added C2+ products presents significant challenges, which is attributed to the slow kinetics of multi‐e− CO2 photoreduction and the high thermodynamic barrier for C–C coupling. Incorporating redox‐active Co2+/Ni2+ cations into lead halide photocatalysts has high potentials to improve carrier transport and introduce charge polarized bimetallic sites, addressing the kinetic and thermodynamic issues, respectively. In this study, a coordination‐driven synthetic strategy is developed to introduce 3d transition metals into the interlamellar region of layered organolead iodides with atomic precision. The resultant bimetallic halide hybrids exhibit selective photoreduction of CO2 to C2H5OH using H2O vapor at the evolution rates of 24.9–31.4 µmol g−1 h−1 and high selectivity of 89.5–93.6%, while pristine layered lead iodide yields only C1 products. Band structure calculations and photoluminescence studies indicate that the interlayer Co2+/Ni2+ species greatly contribute to the frontier orbitals and enhance exciton dissociation into free carriers, facilitating carrier transport between adjacent lead iodide layers. In addition, Bader charge distribution calculations and in situ experimental spectroscopic studies reveal that the asymmetric Ni–O–Pb bimetallic catalytic sites exhibit intrinsic charge polarization, promoting C–C coupling and leading to the formation of the key *OC–CHO intermediate.
Tailor‐Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication
Authors: Ahola Ilari , Raijada Dhara , Cornett Claus , Bøtker Johan , Rantanen Jukka , Genina Natalja 
Published: May 2024

AbstractAn abrupt cessation of antidepressant medication can be challenging due to the appearance of withdrawal symptoms. A slow hyperbolic tapering of an antidepressant, such as citalopram hydrobromide (CHB), can mitigate the withdrawal syndrome. However, there are no viable dosage forms on the market to implement the tapering scheme. A solution using a tunable modular design (TMD) approach to produce flexible and accurate doses of CHB is proposed. This design consists of two parts: 1) a module with a fixed amount of preloaded CHB in a freeze‐dried polymer matrix, and 2) fine‐tuning the CHB dose by inkjet printing. A noncontact food‐grade printer, used for the first time for printing pharmaceuticals, is modified to allow for accurate printing of the highly concentrated CHB ink on the porous CHB‐free or CHB‐preloaded modules. The produced modules with submilligram precision are bench‐marked with commercially available CHB tablets that are manually divided. The TMD covers the entire range of doses needed for the tapering (0.5–23.8 mg). The greatest variance is 13% and 88% when comparing the TMD and self‐tapering, respectively. Self‐tapering is proven inaccurate and showcases the need for the TMD to make available accurate and personalized doses to wean off treatment with CHB.
Thermally Stable 3D‐Metamaterial Designs with Advanced Hyperbolic Dispersion Manipulation and Magnetic Anisotropy
Authors: Song Jiawei , Zhang Di , Moceri Matteo , Dou Hongyi , Zhang Xinghang , Wang Haiyan 
Published: May 2024

AbstractHybrid metamaterials (HMs) have attracted significant research interests owing to their unique optical properties and their ability to manipulate light‐matter interaction in a novel and controlled fashion beyond what any single material offers. Especially 3D HMs are of great interest due to their potential to provide advanced and precise control of such light‐matter interaction in nanoscale. In this study, a set of 3D HM nanocomposite films are designed by integrating three phases, i.e., vertically aligned CoFe2 nanosheets within the matrix of TiN/TaN multilayers. By increasing the number of TiN/TaN multilayers from 2 to 19, a high degree of tunability in optical property has been demonstrated, including well‐tailored optical permittivity, and tunable hyperbolic dispersion from Type‐II to Type‐I. Ferromagnetic CoFe2 nanosheets introduces novel magnetic responses, such as magnetic anisotropy and enhanced coercivity. Furthermore, in situ heating X‐ray diffraction (XRD) suggests good thermal stability of the 3D nanocomposite films up to the measured temperature of 600 °C. This three‐phase 3D nanocomposite design offers more flexibility in HM designs, multifunctionalities, and phase stability, compared with the typical two‐phase HMs toward future metamaterials by design.
Stability of Immobilized Chemosensor‐Filled Vesicles on Anti‐Fouling Polymer Brush Surfaces
Authors: Yang Wenwu , Xiao Jiangxiong , Yang Bingquan , Mathew George , Schäfer Andreas H. , Hirtz Michael 
Published: May 2024

AbstractThe characterization of phospholipid membrane permeability for small molecules is crucial for many applications in drug discovery and biomedical research in general. Here, chemosensor‐laden vesicles offer an attractive platform for permeability assays. In this work, the stability of immobilized chemosensor‐filled vesicles is explored on anti‐fouling polymer brush surfaces for potential use in monitoring small molecule membrane permeability. The study focuses on the development of a method for immobilizing sensor‐loaded vesicles into arbitrary patterns on surfaces and characterizing their stability under changing temperatures and compositions. As substrate to enable intact, long‐term stable vesicle immobilization reactive polymer brushes with anti‐fouling properties are used. Utilizing microchannel cantilever spotting, biotin moieties are introduced on the polymer brush surface, enabling stable tethering of vesicles through streptavidin‐biotin interactions. The immobilized vesicles are monitored through fluorescence microscopy for their response to analytes under changing environmental parameters and vesicle composition. A higher stability of immobilized vesicles compared to free‐floating ones is observed, with permeability only at elevated temperatures. By tuning vesicle compositions, permeability at lower temperatures can be raised again. Overall, the study provides insights into a novel approach for vesicle immobilization, showcasing the potential of surface‐bound vesicles for applications in microfluidic systems and as biosensors in various assays.
Pure Tunable Emissions from Cesium Manganese Bromide by Monitoring the Crystal Fields Through a Sustainable Approach
Authors: Dutta Subhajit , Panchanan Swagata , Kumar Surjeet , Jaafreh Russlan , Yoo Jung Hyeon , Kwon Seok Bin , Hamad Kotiba , Dastgeer Ghulam , Yoon Dae Ho 
Published: May 2024

AbstractResearch on manganese (Mn) halide perovskite derivatives with tunable emissions and high color purity have gathered a significant amount of attention for display technology. Despite of mesmerizing optical properties, the synthesis of these all‐inorganic Mn halide compounds is followed by complex and toxic processes. Second, a precise control over the synthesis parameters is mandatory to achieve their pure emissions. Therefore, an ecologically sustainable water‐based solution approach is adapted here to tailor the phases and emissions of cesium manganese bromide (Cs‐Mn‐Br) perovskite derivatives. It is observed that a controlled injection of solution stabilizer plays a pivotal role in engineering the intrinsic properties of Mn halide perovskites. This solution stabilizer interacts with the Mn‐ions of those perovskite derivatives influencing their surrounding coordination environment and pure emission from then. A pure green emission with PLQY of 82% is achieved from as prepared Cs3MnBr5, whereas CsMnBr3 showed a red emission with PLQY of ≈20%. Encouraged by these properties phosphor‐driven light emitting diodes (LED) are designed that show a steady electroluminescence intensity. The CIE coordinates of the Cs3MnBr5 and CsMnBr3 LED prototypes are at (0.224, 0.659) and (0.688, 0.316). This study showcases simple, eco‐friendly tactics for developing green and red LED prototypes contributing toward sustainable device design.
Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7
Authors: Zhou Xinyi , Yang Xiaoyu , Huang Shenzhen , Lin Guifeng , Lei Kexin , Wang Qian , Lin Weimin , Li Hanwen , Qi Xingying , Seriwatanachai Dutmanee , Yang Shengyong , Shao Bin , Yuan Quan 
Published: May 2024

AbstractN6‐methyladenosine (m6A) modification, installed by METTL3‐METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role in oral mucosal immunity remains ambiguous. Periodontitis is a special but prevalent infectious disease characterized as hyperinflammation of oral mucosa and bone resorption. Here, it is reported that genetic deletion of Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation. Mechanistically, the stability of TNFAIP3 (also known as A20) transcript is significantly attenuated upon m6A modification. When silencing METTL3, accumulated TNFAIP3 functioning as a ubiquitin‐editing enzyme facilitates the ubiquitination of NEK7 [NIMA (never in mitosis gene a)‐related kinase 7], and subsequently impairs NLRP3 inflammasome assembly. Furtherly, Coptisine chloride, a natural small‐molecule, is discovered as a novel METTL3 inhibitor and performs therapeutic effect on periodontitis. The study unveils a previously unknown pathogenic mechanism of METTL3‐mediated m6A modifications in periodontitis and indicates METTL3 as a potential therapeutic target.
Transmural Flow Upregulates PD‐L1 Expression in Microvascular Networks
Authors: Wan Zhengpeng , Zhang Shun , Zhong Amy X. , Xu Liling , Coughlin Mark F. , Pavlou Georgios , Shelton Sarah E. , Nguyen Huu Tuan , Hirose Satomi , Kim Seunggyu , Floryan Marie A. , Barbie David A. , Hodi F. Stephen , Kamm Roger D. 
Published: May 2024

AbstractEndothelial programmed death‐ligand 1 (PD‐L1) expression is higher in tumors than in normal tissues. Also, tumoral vasculatures tend to be leakier than normal vessels leading to a higher trans‐endothelial or transmural fluid flow. However, it is not clear whether such elevated transmural flow can control endothelial PD‐L1 expression. Here, a new microfluidic device is developed to investigate the relationship between transmural flow and PD‐L1 expression in microvascular networks (MVNs). After treating the MVNs with transmural flow for 24 h, the expression of PD‐L1 in endothelial cells is upregulated. Additionally, CD8 T cell activation by phytohemagglutinin (PHA) is suppressed when cultured in the MVNs pre‐conditioned with transmural flow. Moreover, transmural flow is able to further increase PD‐L1 expression in the vessels formed in the tumor microenvironment. Finally, by utilizing blocking antibodies and knock‐out assays, it is found that transmural flow‐driven PD‐L1 upregulation is controlled by integrin αVβ3. Overall, this study provides a new biophysical explanation for high PD‐L1 expression in tumoral vasculatures.
Bi Nanospheres Embedded in N‐Doped Carbon Nanowires Facilitate Ultrafast and Ultrastable Sodium Storage
Authors: Yao Qian , Zheng Cheng , Liu Kejun , Wang Mingyue , Song Jinmei , Cui Lifeng , Huang Di , Wang Nana , Dou Shi Xue , Bai Zhongchao , Yang Jian 
Published: May 2024

AbstractSodium ion batteries (SIBs) are considered as the ideal candidates for the next generation of electrochemical energy storage devices. The major challenges of anode lie in poor cycling stability and the sluggish kinetics attributed to the inherent large Na+ size. In this work, Bi nanosphere encapsulated in N‐doped carbon nanowires (Bi@N‐C) is assembled by facile electrospinning and carbonization. N‐doped carbon mitigates the structure stress/strain during alloying/dealloying, optimizes the ionic/electronic diffusion, and provides fast electron transfer and structural stability. Due to the excellent structure, Bi@N‐C shows excellent Na storage performance in SIBs in terms of good cycling stability and rate capacity in half cells and full cells. The fundamental mechanism of the outstanding electrochemical performance of Bi@N‐C has been demonstrated through synchrotron in‐situ XRD, atomic force microscopy, ex‐situ scanning electron microscopy (SEM) and density functional theory (DFT) calculation. Importantly, a deeper understanding of the underlying reasons of the performance improvement is elucidated, which is vital for providing the theoretical basis for application of SIBs.
SMAD4 mosaicism in juvenile polyposis: Essential contribution of somatic analysis in diagnosis
Authors: Vautier Sabine , Mauillon Jacques , Parodi Nathalie , Bou Jacqueline , Kasper Edwige , Manase Sandrine , Houdayer Claude , Baert‐Desurmont Stéphanie 
Published: May 2024

AbstractJuvenile polyposis syndrome (JPS) is a rare disease characterized by multiple hamartomatous polyps in the gastrointestinal tract, associated with pathogenic variants of BMPR1A and SMAD4. We present the description of SMAD4 mosaicism in a 30‐year‐old man who had caecum adenocarcinoma, 11 juvenile colon polyps and epistaxis since childhood. We conducted NGS polyposis and CRC panel analysis on DNA extracted from two polyps, revealing a likely pathogenic SMAD4 variant: NM_005359.5:c. 1600C>T, p.(Gln534*). This variant was then identified at a very low frequency on blood and normal colonic tissue, by targeted visualization of previously obtained NGS data. These findings support the presence of a likely pathogenic mosaic SMAD4 variant that aligns with the patient's phenotype. Given the relatively frequent occurrence of de novo SMAD4 mutations, somatic mosaicism could account for a significant proportion of sporadic JPS patients with unidentified pathogenic variants. This case underscores the diagnosis challenge of detecting mosaicism and emphasizes the importance of somatic analyses.
Acute alcohol intoxication presenting acquired lesion of the corpus callosum in a young healthy woman: A case of possible Marchiafava–Bignami disease
Authors: Watanabe Makoto , Atagi Nobuhito , Makino Yosuke , Kooguchi Kunihiko , Ohta Bon 
Published: May 2024

AbstractBackgroundMarchiafava–Bignami disease is a rare neurological disease characterized by acquired lesions of the corpus callosum. Although the major causative etiology is chronic alcoholism, a case caused by acute alcohol intoxication has not yet been reported.Case PresentationA 19‐year‐old female with no known medical history or a history of chronic alcohol consumption was brought to the emergency department in a coma after binge alcohol consumption. Even after an overnight observation, she remained comatose. After a thorough examination including magnetic resonance imaging, which showed lesions of the corpus callosum, she was treated with thiamine for Marchiafava–Bignami disease. She recovered completely and at the follow‐up, the callosum lesion had resolved.ConclusionThis is a rare case within the spectrum of Marchiafava–Bignami disease caused by acute consumption of alcohol. Clinicians should be aware of this potentially devastating critical condition among patients with severe alcohol intoxication, which might have been overlooked.
Gold‐Catalysed Heck Reaction: Fact or Fiction? Correspondence on “Unlocking the Chain Walking Process in Gold Catalysis”
Authors: Budzelaar Peter H. M. , Bochmann Manfred , Landrini Martina , Rocchigiani Luca 
Published: May 2024

AbstractTwo recent high‐profile publications reported the formation of Heck‐type arylated alkenes catalysed by MeDalPhosAuCl/AgOTf (J. Am. Chem. Soc. 2023, 145, 8810) and their cyclisation to tetralines (Angew. Chem. Int. Ed. 2023, e202312786). It was claimed that these were the first demonstrations in gold catalysis of alkene insertion into Au‐aryl bonds, β‐H elimination and chain‐walking by Au−H dications. We show here that in fact this chemistry is a two‐stage process. Only the first step, the production of an alkyl triflate ester as the primary organic product by the well‐known alkene heteroarylation sequence, involves gold. The subsequent formation of Heck‐type olefins and their cyclisation to tetralines represent classical H+‐triggered carbocationic chemistry. These steps proceed in the absence of gold with identical results. Literature claims of new gold reactivity such as chain walking by the putative [LAuH]2+ dication have no basis in fact.
Solvation Properties of Neutral Gold Species in Supercritical Water Studied By THz Spectroscopy
Authors: Noetzel Jan , Schienbein Philipp , Forbert Harald , Marx Dominik 
Published: May 2024

AbstractSupercritical water provides distinctly different solvation properties compared to what is known from liquid water. Despite its prevalence deep in the Earth's crust and its role in chemosynthetic ecosystems in the vicinity of hydrothermal vents, molecular insights into its solvation mechanisms are still very scarce compared to what is known for liquid water. Recently, neutral metal particles have been detected in hydrothermal fluids and proposed to explain the transport of gold species to ore deposits on Earth. Using ab initio molecular dynamics, we elucidate the solvation properties of small gold species at supercritical conditions. The neutral metal clusters themselves contribute enormous THz intensity not because of their intramolecular vibrations, but due to their pronounced electronic polarization coupling to the dynamical supercritical solvent, leading to a continuum absorption up to about 1000 cm−1. On top, long‐lived interactions between the gold clusters and solvation water leads at these supercritical conditions to a sharp THz resonance that happens to be close to the one due to H‐bonding in liquid water at ambient conditions. The resulting distinct resonances can be used to analyse the solvation properties of neutral metal particles in supercritical aqueous solutions.
Total Synthesis of Lissodendoric Acid A
Authors: Ippoliti Francesca M. , Wonilowicz Laura G. , Adamson Nathan J. , Darzi Evan R. , Donaldson Joyann S. , Nasrallah Daniel J. , Mehta Milauni M. , Kelleghan Andrew V. , Houk K. N. , Garg Neil K. 
Published: May 2024

AbstractWe describe a full account of our synthetic strategy leading to the first total synthesis of the manzamine alkaloid lissodendoric acid A . These efforts demonstrate that strained cyclic allenes are valuable synthetic building blocks and can be employed efficiently in total synthesis.