bluuebunny/crossref_metadata_2025_split huggingface dataset:
Physical and Unphysical Causes of Nonstationarity in the Relationship Between Barents‐Kara Sea Ice and the North Atlantic Oscillation
Authors: Strommen Kristian , Cooper Fenwick C. 
Published: June 2024

AbstractThe role of internal variability in generating an apparent link between autumn Barents‐Kara sea (BKS) ice and the winter North Atlantic Oscillation (NAO) has been intensely debated. In particular, the robustness and causality of the link has been questioned by showing that BKS‐NAO correlations exhibit nonstationarity in both reanalysis and climate model simulations. We show that the lack of ice observations means nonstationarity cannot be confidently assessed using reanalysis prior to 1961. Model simulations are used to corroborate an argument that forced nonstationarity could result from ice edge changes due to global warming. Consequently, the observed change in BKS‐NAO correlations since 1960 might not be purely a result of internal variability and may also reflect that the ice edge has moved. The change could also reflect the availability of more accurate ice observations. We discuss potential implications for analysis based on coupled climate models, which exhibit large ice edge biases.
Rapid Ice‐Wedge Collapse and Permafrost Carbon Loss Triggered by Increased Snow Depth and Surface Runoff
Authors: Parmentier Frans‐Jan W. , Nilsen Lennart , Tømmervik Hans , Meisel Ove H. , Bröder Lisa , Vonk Jorien E. , Westermann Sebastian , Semenchuk Philipp R. , Cooper Elisabeth J. 
Published: June 2024

AbstractThicker snow cover in permafrost areas causes deeper active layers and thaw subsidence, which alter local hydrology and may amplify the loss of soil carbon. However, the potential for changes in snow cover and surface runoff to mobilize permafrost carbon remains poorly quantified. In this study, we show that a snow fence experiment on High‐Arctic Svalbard inadvertently led to surface subsidence through warming, and extensive downstream erosion due to increased surface runoff. Within a decade of artificially raised snow depths, several ice wedges collapsed, forming a 50 m long and 1.5 m deep thermo‐erosion gully in the landscape. We estimate that 1.1–3.3 tons C may have eroded, and that the gully is a hotspot for processing of mobilized aquatic carbon. Our results show that interactions among snow, runoff and permafrost thaw form an important driver of soil carbon loss, highlighting the need for improved model representation.
Combining Neural Networks and CMIP6 Simulations to Learn Windows of Opportunity for Skillful Prediction of Multiyear Sea Surface Temperature Variability
Authors: Davenport Frances V. , Barnes Elizabeth A. , Gordon Emily M. 
Published: June 2024

AbstractWe use neural networks and large climate model ensembles to explore predictability of internal variability in sea surface temperature (SST) anomalies on interannual (1–3 years) and decadal (1–5 and 3–7 years) timescales. We find that neural networks can skillfully predict SST anomalies at these lead times, especially in the North Atlantic, North Pacific, Tropical Pacific, Tropical Atlantic and Southern Ocean. The spatial patterns of SST predictability vary across the nine climate models studied. The neural networks identify “windows of opportunity” where future SST anomalies can be predicted with more certainty. Neural networks trained on climate models also make skillful SST predictions in reconstructed observations, although the skill varies depending on which climate model the network was trained. Our results highlight that neural networks can identify predictable internal variability within existing climate data sets and show important differences in how well patterns of SST predictability in climate models translate to the real world.
Improving Diurnal Precipitation Forecasts Through Coherent Coupling of Cumulus and Planetary Boundary Layer Parameterizations
Authors: Mei Haixia , Liang Xin‐Zhong , Zeng Mingjian , Yang Yang , Sun Chao , Li Xin 
Published: June 2024

AbstractThis study explores the impact of coupling cumulus and planetary boundary layer (PBL) parameterizations on diurnal precipitation forecasting during the plum rainy season in Jiangsu Province, China, using a double grid‐nesting approach. Results show that coherent coupling of cumulus (only in the 15 km grid outer domain [O]) and PBL parameterizations leads to improved forecasting of diurnal variations in the morning, afternoon, and the evening. Increasing the frequency of the Kain‐Fritsch (KF) cumulus scheme in [O] enhances subgrid precipitation while reducing grid‐scale precipitation, resulting in a more accurate representation of daytime convective activities and a reduction in over‐forecasting of evening valley and early‐morning precipitation. Additionally, coupling a suitable PBL scheme mitigates the overpredicted afternoon peak by facilitating turbulent mixing to penetrate higher altitudes with a thicker layer, thereby reducing instability energy accumulation. A higher KF frequency in [O] retains less low tropospheric moisture, reducing moisture convergence into the 1 km grid inner domain [I] and decreasing overpredicted daytime precipitation in [I]. Various PBL schemes produce distinct vertical distributions of turbulent moisture and heat transport, impacting convection and precipitation in [I] resolved by cloud microphysics processes. The coherent coupling of these parameterizations maintains a balanced supply of convective energy and water vapor, significantly improving diurnal precipitation forecasts in [I]. Isolating these parameterizations between nested grids may undermine this improvement.
Polar Low Circulation Enhances Greenland's West Coast Cloud Surface Warming
Authors: Lac Jean , Chepfer Hélène , Arouf Assia , Shupe Matthew D. , Gallagher Michael R. 
Published: June 2024

AbstractMass loss of the Greenland Ice Sheet (GrIS) plays a major role in the global sea level rise. The west coast of the GrIS has contributed 1,000 Gt of the 4,488 Gt GrIS mass loss between 2002 and 2021, making it a hotspot for GrIS mass loss. Surface melting is driven by changes in the radiative budget at the surface, which are modulated by clouds. Previous works have shown the impact of North Atlantic transport for influencing cloudiness over the GrIS. Here we used space‐based lidar cloud profile observations to show that a polar low circulation promotes the presence of low clouds over the GrIS west coast that warm radiatively the GrIS surface during the melt season. Polar low circulation transports moisture and low clouds from the sea to the west of Greenland up over the GrIS west coast through the melt season. The concomitance of the increasing presence of low cloud in fall over the Baffin Sea due to seasonal sea‐ice retreat and a maximum occurrence of Polar low circulation in September results in a maximum of low cloud fraction (∼14% at 2.5 km above sea level) over the GrIS west coast in September. These low clouds warm radiatively the GrIS west coast surface up to 80 W/m2 locally. This warming contributes to an average increase of 10 W/m2 of cloud surface warming in September compared to July on the GrIS west coast. Overall, this study suggests that regional atmospheric processes independent from North Atlantic transport may also influence the GrIS melt.
Multi‐Task Learning for Tornado Identification Using Doppler Radar Data
Authors: Xie Jinyang , Zhou Kanghui , Chen Haonan , Han Lei , Guan Liang , Wang Maoyu , Zheng Yongguang , Chen Hongjin , Mao Jiaqi 
Published: June 2024

AbstractTornadoes, as highly destructive weather events, require accurate detection for effective decision‐making. Traditional radar‐based tornado detection algorithms (TDA) face challenges with limited tornado feature extraction capabilities, leading to high false alarm rates and low detection probabilities. This study introduces the Multi‐Task Identification Network (MTI‐Net), leveraging Doppler radar data to enhance tornado recognition. MTI‐Net integrates tornado detection and estimation tasks to acquire comprehensive spatial and locational information. As part of MTI‐Net, we introduce a novel backbone network of Multi‐Head Convolutional Block (MHCB), which incorporates Spatial and Channel Attention Units (SAU and CAU). SAU optimizes local tornado feature extraction, while CAU reduces false alarms by enhancing dependencies among input variables. Experiments demonstrate the superiority of MTI‐Net over TDA, with a decrease in false alarm rates from 0.94 to 0.46 and an increase in hit rates from 0.23 to 0.81, highlighting the effectiveness of MTI‐Net in handling small‐scale tornado events.
A systematic review of recruitment and retention of ethnic minorities and migrants in obesity prevention randomised controlled trials
Authors: Wali Nidhi , Huda Md. Nazmul , Gill Timothy , Green Julie , Renzaho Andre M. N. 
Published: June 2024

Abstract
Background
Participants’ recruitment and retention into community-based interventions can be challenging, especially in research involving ethnic minorities and migrants. Despite known challenges, there are limited reviews that probe recruitment and retention strategies involving ethnic minorities and migrants in the Organisation for Economic Cooperation and Development (OECD) countries. This systematic review aimed to measure recruitment and retention rates and identify the barriers and facilitators to effective recruitment and retention of ethnic minorities and migrants in community-based obesity prevention Randomised Control Trials (RCTs) in OECD countries.

Methods
This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Five databases (CINAHL, Cochrane, Embase, Medline and PsychInfo) were searched from January 2000 to March 2022, in addition to Google and Google Scholar. Methodological quality and risk of bias were assessed, and pooled analysis and meta-ethnographic analysis were conducted on the included studies.

Results
Twenty-five studies were included in the review. The pooled analysis found a 64% rate of recruitment of ethnic minorities in RCTs, with a retention rate of 71%. Key facilitators identified were—use of multiple communication channels, incentives, recruiting community champions, participant convenience and employing culturally sensitive strategies. Key barriers to participation were limited access to study sites, time constraints, limited trust, perceived fear, and anxiety.

Conclusion
Findings suggest the importance of undertaking culturally appropriate recruitment and retention strategies to minimise barriers and facilitate effective recruitment and retention of low-income ethnic minorities and migrants in community-based research.
FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation
Authors: Zhang Pengfei , Yang Ju , Liu Xiong , Huang Congshu , Tao Yuandong , Shen Pan , Bai Zhijie , Xiao Chengrong , Zhou Lei , Li Gaofu , Zhang Li , Zhou Wei , Gao Yue 
Published: June 2024

AbstractKeratinocyte proliferation and differentiation in epidermis are well-controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a characteristic feature of major human skin diseases such as psoriasis and squamous cell carcinoma. However, the effect of keratinocyte metabolism on proliferation and differentiation remains largely elusive. We show here that the gluconeogenic enzyme fructose-1,6-bisphosphatase 1 (FBP1) promotes differentiation while inhibits proliferation of keratinocyte and suppresses psoriasis development. FBP1 is identified among the most upregulated genes induced by UVB using transcriptome sequencing and is elevated especially in upper epidermis. Fbp1 heterozygous mice exhibit aberrant epidermis phenotypes with local hyperplasia and dedifferentiation. Loss of FBP1 promotes proliferation and inhibits differentiation of keratinocytes in vitro. Mechanistically, FBP1 loss facilitates glycolysis-mediated acetyl-CoA production, which increases histone H3 acetylation at lysine 9, resulting in enhanced transcription of proliferation genes. We further find that the expression of FBP1 is dramatically reduced in human psoriatic lesions and in skin of mouse imiquimod psoriasis model. Fbp1 deficiency in mice facilitates psoriasis-like skin lesions development through glycolysis and acetyl-CoA production. Collectively, our findings reveal a previously unrecognized role of FBP1 in epidermal homeostasis and provide evidence for FBP1 as a metabolic psoriasis suppressor.
The structure of the TH/INS locus and the parental allele expressed are not conserved between mammals
Authors: Newman Trent , Ishihara Teruhito , Shaw Geoff , Renfree Marilyn B. 
Published: June 2024

AbstractParent-of-origin-specific expression of imprinted genes is critical for successful mammalian growth and development. Insulin, coded by the INS gene, is an important growth factor expressed from the paternal allele in the yolk sac placenta of therian mammals. The tyrosine hydroxylase gene TH encodes an enzyme involved in dopamine synthesis. TH and INS are closely associated in most vertebrates, but the mouse orthologues, Th and Ins2, are separated by repeated DNA. In mice, Th is expressed from the maternal allele, but the parental origin of expression is not known for any other mammal so it is unclear whether the maternal expression observed in the mouse represents an evolutionary divergence or an ancestral condition. We compared the length of the DNA segment between TH and INS across species and show that separation of these genes occurred in the rodent lineage with an accumulation of repeated DNA. We found that the region containing TH and INS in the tammar wallaby produces at least five distinct RNA transcripts: TH, TH-INS1, TH-INS2, lncINS and INS. Using allele-specific expression analysis, we show that the TH/INS locus is expressed from the paternal allele in pre- and postnatal tammar wallaby tissues. Determining the imprinting pattern of TH/INS in other mammals might clarify if paternal expression is the ancestral condition which has been flipped to maternal expression in rodents by the accumulation of repeat sequences.
Microorganism-mediated denitrogenation of aquaculture systems provoked by poly-β-hydroxybutyrate (PHB)
Authors: Xia Yun , Liu Yarong , Zhang Kai , Sun Jinhui , Wang Guangjun , Li Zhifei , Tian Jingjing , Gong Wangbao , Li Hongyan , Xie Wenping , Kaneko Gen , Xie Jun , Yu Ermeng 
Published: June 2024

AbstractThe biodegradable polymer poly-β-hydroxybutyrate (PHB) is a promising carbon source for biological mitigation of nitrogen pollution, a significant problem in aquaculture that physical and chemical methods have not provided a comprehensive solution. Here we investigated the impact of PHB on the zero-water-change largemouth bass culture by 30- and 40-day experiments. PHB loaded into the filter circulation pump at 4 g L−1, optimum value determined by the first experiment, significantly reduced the levels of nitrate by 99.65%, nitrite by 95.96%, and total nitrogen by 85.22% compared to the control without PHB. PHB also significantly increased denitrifying bacteria (e.g., Proteobacteria and Fusobacteria) and expression of denitrification genes (e.g., nirK and nirS) in the microbial community, improving growth and health parameters of largemouth bass. While the impact may vary in other culture systems, PHB thus demonstrated its remarkable utility in aquaculture, highlighting ecological assessment and application to larger aquaculture operations as future considerations.
Non-literacy biased, culturally fair cognitive detection tool in primary care patients with cognitive concerns: a randomized controlled trial
Authors: Verghese Joe , Chalmer Rachel , Stimmel Marnina , Weiss Erica , Zwerling Jessica , Malik Rubina , Rasekh David , Ansari Asif , Corriveau Roderick A. , Ehrlich Amy R. , Wang Cuiling , Ayers Emmeline 
Published: June 2024

AbstractDementia is often undiagnosed in primary care, and even when diagnosed, untreated. The 5-Cog paradigm, a brief, culturally adept, cognitive detection tool paired with a clinical decision support may reduce barriers to improving dementia diagnosis and care. We performed a randomized controlled trial in primary care patients experiencing health disparities (racial/ethnic minorities and socioeconomically disadvantaged). Older adults with cognitive concerns were assigned in a 1:1 ratio to the 5-Cog paradigm or control. Primary outcome was improved dementia care actions defined as any of the following endpoints within 90 days: new mild cognitive impairment syndrome or dementia diagnoses as well as investigations, medications or specialist referrals ordered for cognitive indications. Groups were compared using intention-to-treat principles with multivariable logistic regression. Overall, 1,201 patients (mean age 72.8 years, 72% women and 94% Black, Hispanic or Latino) were enrolled and 599 were assigned to 5-Cog and 602 to the control. The 5-Cog paradigm demonstrated threefold odds of improvement in dementia care actions over control (odds ratio 3.43, 95% confidence interval 2.32–5.07). No serious intervention-related adverse events were reported. The 5-Cog paradigm improved diagnosis and management in patients with cognitive concerns and provides evidence to promote practice change to improve dementia care actions in primary care.ClinicalTrials.gov: NCT03816644.
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease
Authors: Horváth Vivien , Garza Raquel , Jönsson Marie E. , Johansson Pia A. , Adami Anita , Christoforidou Georgia , Karlsson Ofelia , Castilla Vallmanya Laura , Koutounidou Symela , Gerdes Patricia , Pandiloski Ninoslav , Douse Christopher H. , Jakobsson Johan 
Published: June 2024

AbstractSVA (SINE (short interspersed nuclear element)–VNTR (variable number of tandem repeats)–Alu) retrotransposons remain active in humans and contribute to individual genetic variation. Polymorphic SVA alleles harbor gene regulatory potential and can cause genetic disease. However, how SVA insertions are controlled and functionally impact human disease is unknown. Here we dissect the epigenetic regulation and influence of SVAs in cellular models of X-linked dystonia parkinsonism (XDP), a neurodegenerative disorder caused by an SVA insertion at the TAF1 locus. We demonstrate that the KRAB zinc finger protein ZNF91 establishes H3K9me3 and DNA methylation over SVAs, including polymorphic alleles, in human neural progenitor cells. The resulting mini-heterochromatin domains attenuate the cis-regulatory impact of SVAs. This is critical for XDP pathology; removal of local heterochromatin severely aggravates the XDP molecular phenotype, resulting in increased TAF1 intron retention and reduced expression. Our results provide unique mechanistic insights into how human polymorphic transposon insertions are recognized and how their regulatory impact is constrained by an innate epigenetic defense system.
Allosteric competition and inhibition in AMPA receptors
Authors: Hale W. Dylan , Montaño Romero Alejandra , Gonzalez Cuauhtemoc U. , Jayaraman Vasanthi , Lau Albert Y. , Huganir Richard L. , Twomey Edward C. 
Published: June 2024

AbstractExcitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through unresolved mechanisms. Here we show that allosteric inhibition pushes AMPARs into a distinct state that prevents both activation and positive allosteric modulation. We used cryo-electron microscopy to capture AMPARs bound to glutamate, while a negative allosteric modulator, GYKI-52466, and positive allosteric modulator, cyclothiazide, compete for control of the AMPARs. GYKI-52466 binds in the ion channel collar and inhibits AMPARs by decoupling the ligand-binding domains from the ion channel. The rearrangement of the ligand-binding domains ruptures the cyclothiazide site, preventing positive modulation. Our data provide a framework for understanding allostery of AMPARs and for rational design of therapeutics targeting AMPARs in neurological diseases.
Raman scattering owing to magneto-polaron states in monolayer transition metal dichalcogenides
Authors: Trallero-Giner C. , Santiago-Pérez D. G. , Tkachenko D. V. , Marques G. E. , Fomin V. M. 
Published: June 2024

AbstractMagneto-optical measurements are fundamental research tools that allow for studying the hitherto unexplored optical transitions and the related applications of topological two-dimensional (2D) transition metal dichalcogenides (TMDs). A theoretical model is developed for the first-order magneto-resonant Raman scattering in a monolayer of TMD. A significant number of avoided crossing points involving optical phonons in the magneto-polaron (MP) spectrum, a superposition of the electron and hole states in the excitation branches, and their manifestations in optical transitions at various light scattering configurations are unique features for these 2D structures. The Raman intensity reveals three resonant splittings of double avoided-crossing levels. The three excitation branches are present in the MP spectrum provoked by the coupling of the Landau levels in the conduction and valence bands via an out-of-plane $$A_1$$

A
1

-optical phonon mode. The energy gaps at the anticrossing points in the MP scattering spectrum are revealed as a function of the electron and hole optical deformation potential constants. The resonant MP Raman scattering efficiency profile allows for quantifying the relative contribution of the conduction and valence bands in the formation of MPs. The results obtained are a guideline for controlling MP effects on the magneto-optical properties of TMD semiconductors, which open pathways to novel optoelectronic devices based on 2D TMDs.
Comprehensive analysis of the editing window of C-to-T TALE base editors
Authors: Feola Maria , Pulicani Sylvain , Tkach Diane , Boyne Alex , Hong Robert , Mayer Louisa , Duclert Aymeric , Duchateau Philippe , Juillerat Alexandre 
Published: June 2024

AbstractOne of the most recent advances in the genome editing field has been the addition of “TALE Base Editors”, an innovative platform for cell therapy that relies on the deamination of cytidines within double strand DNA, leading to the formation of an uracil (U) intermediate. These molecular tools are fusions of transcription activator-like effector domains (TALE) for specific DNA sequence binding, split-DddA deaminase halves that will, upon catalytic domain reconstitution, initiate the conversion of a cytosine (C) to a thymine (T), and an uracil glycosylase inhibitor (UGI). We developed a high throughput screening strategy capable to probe key editing parameters in a precisely defined genomic context in cellulo, excluding or minimizing biases arising from different microenvironmental and/or epigenetic contexts. Here we aimed to further explore how target composition and TALEB architecture will impact the editing outcomes. We demonstrated how the nature of the linker between TALE array and split DddAtox head allows us to fine tune the editing window, also controlling possible bystander activity. Furthermore, we showed that both the TALEB architecture and spacer length separating the two TALE DNA binding regions impact the target TC editing dependence by the surrounding bases, leading to more restrictive or permissive editing profiles.