bluuebunny/crossref_metadata_2025_split huggingface dataset:
“You go in heavy and you come out light”: An interpretative phenomenological analysis of reflective practice experiences in an Irish infant mental health setting
Authors: Tobin Mary , O'Sullivan Nicola , Rogers Elaine 
Published: May 2024

AbstractReflective practice (RP) is a core component of infant mental health (IMH); however, there is limited published empirical research on IMH practitioner experiences of RP. This two‐stage, qualitative, multimodal study explored Irish IMH practitioners’ experiences of RP spaces. Visual and verbal data from seven individual interviews and a participatory arts‐based focus group with seven participants (eight participants in total, all white Irish females) were analyzed using Interpretative Phenomenological Analysis. Five group experiential themes (Just get on with it; What should I be bringing to this space?; Who are my “hands”?; Taking a step back; and You go in heavy and you come out light) were generated by the analysis. These were used to construct a developmental and experiential model of learning in an RP space. The themes portray how a practitioner's RP experience can change over time: influenced by prior experiences and practice development stage, practitioners move from initial uncertainty, anxiety, and perceived pressure in a busy workload to developing the trust and ability to be vulnerable in an RP space. Through relationships (supervisor/facilitator or group members), a shared safe space can be created, which addresses practitioners’ needs for containment, allowing for experiential learning through a process of transformational moments.
News or animal spirits? Consumer confidence and economic activity: Redux
Authors: Choi Sangyup , Jeong Jaehun , Park Dohyeon , Yoo Donghoon 
Published: May 2024

SummaryBarsky and Sims (2012, AER) demonstrated, via indirect inference, that confidence innovations can be viewed as noisy signals about medium‐term economic growth. They highlighted that the connection between confidence and subsequent activity, such as consumption and output, is primarily driven by news shocks about the future. We expand upon their research by incorporating the Great Recession and ZLB episodes, during which animal spirits have a greater potential to influence economic activity. Nevertheless, we confirm the main finding of Barsky and Sims (2012) that this relationship is predominantly driven by news about the future rather than animal spirits.
Ononin: A comprehensive review of anticancer potential of natural isoflavone glycoside
Authors: Sharma Ujjawal , Sharma Bunty , Mishra Ambrish , Sahu Anidrisha , Mathkor Darin M. , Haque Shafiul , Raina Deepika , Ramniwas Seema , Gupta Madhu , Tuli Hardeep S. 
Published: May 2024

AbstractCancer is one of the major causes of death worldwide, with more than 10 million deaths annually. Despite tremendous advances in the health sciences, cancer continues to be a substantial global contributor to mortality. The current treatment methods demand a paradigm shift that not only improves therapeutic efficacy but also minimizes the side effects of conventional medications. Recently, an increased interest in the potential of natural bioactive compounds in the treatment of several types of cancer has been observed. Ononin, also referred to as formononetin‐7‐O‐β‐d‐glucoside, is a natural isoflavone glycoside, derived from the roots, stems, and rhizomes of various plants. It exhibits a variety of pharmacological effects, including Antiangiogenic, anti‐inflammatory, antiproliferative, proapoptotic, and antimetastatic activities. The current review presents a thorough overview of sources, chemistry, pharmacokinetics, and the role of ononin in affecting various mechanisms involved in cancer. The review also discusses potential synergistic interactions with other compounds and therapies. The combined synergistic effect of ononin with other compounds increased the efficacy of treatment methods. Finally, the safety studies, comprising both in vitro and in vivo assessments of ononin's anticancer activities, are described.
Impact of varying maternal dietary folate intake on cerebellar cortex histomorphology and cell density in offspring rats
Authors: Mwachaka Philip Maseghe , Gichangi Peter , Abdelmalek Adel , Odula Paul , Ogeng'o Julius 
Published: May 2024

AbstractThe cerebellum has a long, protracted developmental period that spans from the embryonic to postnatal periods; as a result, it is more sensitive to intrauterine and postnatal insults like nutritional deficiencies. Folate is crucial for foetal and early postnatal brain development; however, its effects on cerebellar growth and development are unknown. The aim of this study was to examine the effects of maternal folate intake on the histomorphology and cell density of the developing cerebellum. Twelve adult female rats (rattus norvegicus) were randomly assigned to one of four premixed diet groups: standard (2 mg/kg), folate‐deficient (0 mg/kg), folate‐supplemented (8 mg/kg) or folate supra‐supplemented (40 mg/kg). The rats started their diets 14 days before mating and consumed them throughout pregnancy and lactation. On postnatal days 1, 7, 21 and 35, five pups from each group were sacrificed, and their brains were processed for light microscopic analysis. Histomorphology and cell density of the external granule, molecular, Purkinje and internal granule layers were obtained. The folate‐deficient diet group had smaller, dysmorphic cells and significantly lower densities of external granule, molecular, Purkinje and internal granule cells. Although the folate‐enriched groups had greater cell densities than the controls, the folate‐supplemented group had considerably higher cell densities than the supra‐supplemented group. The folate supra‐supplemented group had ectopic Purkinje cells in the internal granule cell layer. These findings imply that a folate‐deficient diet impairs cellular growth and reduces cell density in the cerebellar cortex. On the other hand, folate supplementation increases cell densities, but there appears to be an optimal dose of supplementation since excessive folate levels may be detrimental.
Exploring free amino acid profiles in Crimean‐Congo hemorrhagic fever patients: Implications for disease progression
Authors: Büyüktuna Seyit Ali , Yerlitaş Serra İlayda , Zararsız Gözde Ertük , Doğan Kübra , Kablan Demet , Bağcı Gökhan , Özer Selda , Baysal Cihad , Çakır Yasemin , Cephe Ahu , Koçhan Necla , Zararız Gökmen , Doğan Halef Okan 
Published: May 2024

AbstractThis study investigated the intricate interplay between Crimean‐Congo hemorrhagic fever virus infection and alterations in amino acid metabolism. The primary aim is to elucidate the impact of Crimean‐Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography‐tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease.
Rotavirus trends and distribution of genotypes before and during COVID‐19 pandemic era: Bangladesh, 2017–2021
Authors: Haque Warda , Talha Muhammad , Rahman Sezanur , Hasan Mehedi , Alam Shaheen , Hassan Zahid , Moni Sayra , Khan Sadia H. , Hossain Mohammad E. , Faruque Abu S. G. , Hasan S. M. Tafsir , Khan Soroar H. , Ahmed Tahmeed , Zaman Khalequz , Rahman Mustafizur 
Published: May 2024

AbstractRotavirus gastroenteritis is accountable for an estimated 128 500 deaths among children younger than 5 years worldwide, and the majority occur in low‐income countries. Although the clinical trials of rotavirus vaccines in Bangladesh revealed a significant reduction of severe rotavirus disease by around 50%, the vaccines are not yet included in the routine immunization program. The present study was designed to provide data on rotavirus diarrhea with clinical profiles and genotypes before (2017–2019) and during the COVID‐19 pandemic period (2020–2021). Fecal samples were collected from 2% of the diarrheal patients at icddr,b Dhaka hospital of all ages between January 2017 and December 2021 and were tested for VP6 rotavirus antigen using ELISA. The clinical manifestations such as fever, duration of diarrhea and hospitalization, number of stools, and dehydration and so on were collected from the surveillance database (n = 3127). Of the positive samples, 10% were randomly selected for genotyping using Sanger sequencing method. A total of 12 705 fecal samples were screened for rotavirus A antigen by enzyme immunoassay. Overall, 3369 (27%) were rotavirus antigen‐positive, of whom children <2 years had the highest prevalence (88.6%). The risk of rotavirus A infection was 4.2 times higher in winter than in summer. Overall, G3P[8] was the most prominent genotype (45.3%), followed by G1P[8] (32.1%), G9P[8] (6.8%), and G2P[4] (6.1%). The other unusual combinations, such as G1P[4], G1P[6], G2P[6], G3P[4], G3P[6], and G9P[6], were also present. Genetic analysis on Bangladeshi strains revealed that the selection pressure (dN/dS) was estimated as <1. The number of hospital visits showed a 37% drop during the COVID‐19 pandemic relative to the years before the pandemic. Conversely, there was a notable increase in the rate of rotavirus positivity during the pandemic (34%, p < 0.00) compared to the period before COVID‐19 (23%). Among the various clinical symptoms, only the occurrence of watery stool significantly increased during the pandemic. The G2P[4] strain showed a sudden rise (19%) in 2020, which then declined in 2021. In the same year, G1P[8] was more prevalent than G3P[8] (40% vs. 38%, respectively). The remaining genotypes were negligible and did not exhibit much fluctuation. This study reveals that the rotavirus burden remained high during the COVID‐19 prepandemic and pandemic in Bangladesh. Considering the lack of antigenic variations between the circulating and vaccine‐targeted strains, integrating the vaccine into the national immunization program could reduce the prevalence of the disease, the number of hospitalizations, and the severity of cases.
Unveiling the role of KSHV‐infected human mesenchymal stem cells in Kaposi's sarcoma initiation
Authors: Lacunza Ezequiel , Ahuja Anuj , Coso Omar A. , Abba Martin , Ramos Juan Carlos , Cesarman Ethel , Mesri Enrique A. , Naipauer Julian 
Published: May 2024

AbstractKaposi's sarcoma (KS) may derive from Kaposi's sarcoma herpesvirus (KSHV)‐infected human mesenchymal stem cells (hMSCs) that migrate to sites characterized by inflammation and angiogenesis, promoting the initiation of KS. By analyzing the RNA sequences of KSHV‐infected primary hMSCs, we have identified specific cell subpopulations, mechanisms, and conditions involved in the initial stages of KSHV‐induced transformation and reprogramming of hMSCs into KS progenitor cells. Under proangiogenic environmental conditions, KSHV can reprogram hMSCs to exhibit gene expression profiles more similar to KS tumors, activating cell cycle progression, cytokine signaling pathways, endothelial differentiation, and upregulating KSHV oncogenes indicating the involvement of KSHV infection in inducing the mesenchymal‐to‐endothelial (MEndT) transition of hMSCs. This finding underscores the significance of this condition in facilitating KSHV‐induced proliferation and reprogramming of hMSCs towards MEndT and closer to KS gene expression profiles, providing further evidence of these cell subpopulations as precursors of KS cells that thrive in a proangiogenic environment.
A pharmacokinetic model for hyperpolarized 13C‐pyruvate MRI when using metabolite‐specific bSSFP sequences
Authors: Sahin Sule , Garnæs Marie Frederikke , Bennett Anna , Dwork Nicholas , Tang Shuyu , Liu Xiaoxi , Vaidya Manushka , Wang Zhen Jane , Larson Peder E. Z. 
Published: May 2024

AbstractPurposeMetabolite‐specific balanced SSFP (MS‐bSSFP) sequences are increasingly used in hyperpolarized [1‐13C]Pyruvate (HP 13C) MRI studies as they improve SNR by refocusing the magnetization each TR. Currently, pharmacokinetic models used to fit conversion rate constants, kPL and kPB, and rate constant maps do not account for differences in the signal evolution of MS‐bSSFP acquisitions.MethodsIn this work, a flexible MS‐bSSFP model was built that can be used to fit conversion rate constants for these experiments. The model was validated in vivo using paired animal (healthy rat kidneys n = 8, transgenic adenocarcinoma of the mouse prostate n = 3) and human renal cell carcinoma (n = 3) datasets. Gradient echo (GRE) acquisitions were used with a previous GRE model to compare to the results of the proposed GRE‐bSSFP model.ResultsWithin simulations, the proposed GRE‐bSSFP model fits the simulated data well, whereas a GRE model shows bias because of model mismatch. For the in vivo datasets, the estimated conversion rate constants using the proposed GRE‐bSSFP model are consistent with a previous GRE model. Jointly fitting the lactate T2 with kPL resulted in less precise kPL estimates.ConclusionThe proposed GRE‐bSSFP model provides a method to estimate conversion rate constants, kPL and kPB, for MS‐bSSFP HP 13C experiments. This model may also be modified and used for other applications, for example, estimating rate constants with other hyperpolarized reagents or multi‐echo bSSFP.
Investigating the emigration intention of health care workers: A cross‐sectional study
Authors: Badru Oluwaseun Abdulganiyu , Alabi Tunde Adeyemo , Okerinde Samuel Sijibomi , Kabir Muhammad Auwal , Abdulrazaq Aisha , Adeagbo Oluwafemi Atanda , Badru Fatai Adesina 
Published: May 2024

AbstractAimsTo (1) explore the intramigration experience of HCWs within Nigeria, (2) explore the migration intention of health care workers (HCWs) in Nigeria and (3) identify the predictors of migration intention among HCWs in Nigeria.DesignCross‐sectional study.MethodsThe online survey was used to collect data from 513 HCWs in Nigeria between May and June 2023. Crude and adjusted logistic regression were used to identify factors associated with emigration intention. Analyses were performed on SPSS version 26 at a 95% confidence interval.ResultsThe study found that 34.4% had intramigration experience, and the rate of intention to emigrate to work in another country was 80.1%. The United Kingdom was the most preferred destination (109 HCWs), followed by Canada (92 HCWs) and the United States (82 HCWs). At the multivariate level, emigration intention was associated with the experience of burnout and duration of practice as a HCW. Nurses had higher emigration intentions than medical doctors.ConclusionsMany HCWs in Nigeria appear to have emigration intent, and nurses are more likely to be willing to migrate than doctors. The Nigerian government may want to explore strategies to reverse the emigration intent of the HCWs in Nigeria.
Hyalinizing clear cell carcinoma of the base of tongue: A case report with distant metastasis
Authors: Hiraga Chiho , Ishikawa Saki , Hashimoto Kazuhiko , Suzuki Taiki , Sato Kazumichi , Nomura Takeshi 
Published: May 2024

AbstractBackgroundHyalinizing clear cell carcinoma (HCCC) is a rare, typically low‐grade malignant salivary gland tumor. We present a case of HCCC with multiple metastasis.Case PresentationThe patient was a 34‐year‐old woman with a tumor at the base of tongue. HCCC was diagnosed by FISH analysis for EWSR1‐ATF1 rearrangement after surgery. Systematic metastasis was identified at a three‐year follow‐up. Signs of Rouviere lymph metastasis and distant metastases (i.e., pleura, mediastinum, and gluteus maximus) were identified. The patient died because her condition deteriorated with multiple metastases.ConclusionThe potential for aggressive HCCC should be considered while offering treatment.
Hesperidin reduces systolic blood pressure in diabetic patients and has no effect on blood pressure in healthy individuals: A systematic review and meta‐analysis
Authors: Gao Haifeng , Chen Fang , Wang Shuo 
Published: May 2024

AbstractIn recent years, there have been a number of studies where hesperidin was administered to modify arterial blood pressure, but the conclusions of each study are contradictory. In order to investigate the effect of hesperidin on blood pressure, we searched the CNKI, Wanfang Database, the VIP database, Sinomed database, Pubmed, Embase and The Cochrane Library databases, and searched the literature on hesperidin and blood pressure published in Chinese and English journals, mainly focusing on patients' systolic blood pressure and diastolic blood pressure. The search time frame was from the inception of the databases until December 2023. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to assess the overall quality and used Cohen's kappa coefficient (κ) to measure agreement. We did preliminary screening of the retrieved literature through Notexpress, 14 articles with a total of 656 patients were included. Cochrance data conversion tool was used for data conversion, and RevMan 5.3 was used for meta‐analysis, and finally Stata was used to make the Egger's test for the included study. The results of total population blood pressure showed that hesperidin had no antihypertensive effect on the population, but the conclusions changed when the population was divided into groups. The results of different populations showed that hesperidin had no effect on systolic blood pressure (weighted mean difference [WMD] = −0.50, 95% CI: −3.25 ~ 2.26, Z = 0.35, p = 0.72) and diastolic blood pressure (WMD = −0.51, 95% CI: −2.53 ~ 1.51, Z = 0.50, p = 0.62) in healthy individuals. However, hesperidin reduced systolic blood pressure in patients with type 2 diabetes (WMD = −4.32, 95% CI: − 7.77 ~ − 0.87, Z = 2.45, p = 0.01), and had a tendency to reduce diastolic blood pressure in diabetic patients (WMD = −3.72, 95% CI: −7.63 ~ 0.18, Z = 1.87, p = 0.06). The results in patients with type 2 diabetes needed to be further supported by future research focusing on individuals with diabetes.
Synergetic Electrostatic and Steric Effects in α‐FAPbI3 Single Crystals For X‐Ray Detection and Imaging
Authors: Jiang Wei , Li Haibin , Liu Dan , Ren Jiwei , Zhao Yingying , Wu Jiarui , Chen Jun , Zhou Linsen , Wang Feng , Zhao Yiying 
Published: May 2024

AbstractIt is still challenging to stabilize α‐FAPbI3 perovskite for high performance optoelectrical devices. Herein, a novel strategy is proposed utilizing the synergetic electrostatic and steric effect to stabilize the α‐FAPbI3 phase and suppress the ion migration. Dimethylamine (DMA+) cations are chosen as the dopant to fabricate FA0.96DMA0.04PbI3 single crystals (SCs). DFT calculations reveal that DMA+ cations can improve the stability of α‐FAPbI3 phase in both thermodynamics (lower Gibbs free energy) and kinetics (higher defect formation and migration energy). The resulting SCs exhibit an environmental stability over 100 days and an extraordinary low dark current drift of 3.7 × 10−7 nA cm−1 s−1 V−1, comparable to 2D perovskite SCs. The X‐ray detectors have also achieved the‐state‐of‐the‐art performance in X‐ray detection and imaging. This work demonstrates the significance of electrostatic and steric effects in improving the phase and operational stability of perovskites.
Versorgung und Krankheitskosten der Urtikaria bei Kindern in Deutschland
Authors: Staubach Petra , Mann Caroline , Hagenström Kristina , Augustin Matthias 
Published: May 2024

Zusammenfassung
Hintergrund
Daten zu den Verlaufsformen der Urtikaria bei Kindern existieren, es mangelt jedoch an fundierten Daten, um eine qualitativ hochwertige Versorgung zu gewährleisten.

Methode
Es erfolgte eine retrospektive Sekundärdatenanalyse bei Kindern mit Urtikaria in den Routinedaten einer deutschen Krankenversicherung (DAK-Gesundheit). Eingeschlossen wurden Versicherte unter 18 Jahren, die 2010 bis 2015 ambulant oder stationär mit Urtikariadiagnose (gemäß ICD-10-Klassifikation) behandelt wurden. Statistische Vergleiche wurden nach Adjustierung von Alter und Geschlecht gegenüber Personen ohne Urtikariadiagnose vorgenommen.

Ergebnisse
Im Jahr 2015 wiesen unter 151.248 minderjährigen Versicherten 1904 (1,3 %) eine Urtikariadiagnose auf; 70,9 % der Kinder mit Urtikaria besuchten mindestens einen ambulanten Arzt, von diesen Visiten fanden 70,9 % beim Kinderarzt, 52,5 % beim Allgemeinmediziner und 33,0 % beim Dermatologen statt; 11 % wurden stationär behandelt; 72,9 % der Kinder und Jugendlichen mit Urtikaria vs. 28,9 % ohne wurden topisch oder systemisch behandelt, darunter 10,5 % vs. 2,6 % mit topischen Therapien und 70,0 % vs. 27,5 % mit Systemtherapien. Die am häufigsten eingesetzten oralen Medikamente bei Urtikaria waren Cetirizin (44,2 %), Prednisolon (9,8 %) und Dimetinden (2,0 %). Topisch wurde am häufigsten Methylprednisolonaceponat (49,8 %) verordnet. Die Therapiekosten für systemische Arzneimittel betrugen 24,00 € pro Patient, die für topische 1,58 € pro Patient.

Diskussion
Die Versorgung der chronischen Urtikaria im Kindes- und Jugendalter wird im Wesentlichen durch Kinder‑, Haus- und Hautärzte getragen. Systemische und topische Arzneimittel sowie stationäre Leistungen stellen die wichtigsten Kostenfaktoren dar.
A visual foreign object detection system for wireless charging of electric vehicles
Authors: Shahbaz Nejad Bijan , Roch Peter , Handte Marcus , Marrón Pedro José 
Published: May 2024

AbstractWireless charging of electric vehicles can be achieved by installing a transmitter coil into the ground and a receiver coil at the underbody of a vehicle. In order to charge efficiently, accurate alignment of the charging components must be accomplished, which can be achieved with a camera-based positioning system. Due to an air gap between both charging components, foreign objects can interfere with the charging process and pose potential hazards to the environment. Various foreign object detection systems have been developed with the motivation to increase the safety of wireless charging. In this paper, we propose a foreign object detection technique that utilizes the integrated camera of an embedded positioning system. Due to operation in an outdoor environment, we cannot determine the types of objects that may occur in advance. Accordingly, our approach achieves object-type independence by learning the features of the charging surface, to then classify anomalous regions as foreign objects. To examine the capability of detecting foreign objects, we evaluate our approach by conducting experiments with images depicting known and unknown object types. For the experiments, we use an image dataset recorded by a positioning camera of an operating wireless charging station in an outdoor environment, which we published alongside our research. As a benchmark system, we employ YOLOv8 (Jocher et al. in Ultralytics YOLO, 2023), a state-of-the-art neural network that has been used in various contexts for foreign object detection. While we acknowledge the performance of YOLOv8 for known object types, our approach achieves up to 18% higher precision and 46% higher detection success for unknown objects.