bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shaking table test and numerical analyses of a multi‐story traditional tower‐style building
Authors: Ling Huaiquan , Xue Jianyang , Qi Liangjie 
Published: May 2024

AbstractThe traditional tower‐style building (TTSB) is an innovative structural form constructed in modern cities imitating the overall appearance of ancient timber pagodas, and it is an extraordinarily cultured high‐rise construction. The limited stipulations for high‐rise TTSBs in the seismic design code pose challenges in assessing the reliable performance of the unique structure subjected to severe earthquakes. This paper presents the shaking table test and numerical analyses of a 1/15‐scale 13‐story TTSB specimen with an integral tower height of 5.36 m, which is a steel frame‐braced core‐tube structure consisting of seven bright floors (built‐out stories evident from the outside, BF) and six dim floors (built‐in stories not apparent from the outside, DF), with transition columns and stiffening trusses around the exterior perimeter. The experimental results showed that the tested tower‐style building had excellent seismic performance and reliable structural integrity. It only experienced minor damage when subjected to extremely high‐intensity motions. The interstory drift, dynamic strain, and floor acceleration response of the core‐tube region with eccentric steel braces were more significant under severe excitation than those with cross‐centered symmetric steel braces. The vertical reaction increased at the upper floor of the tower under vertical acceleration, and differences in the dynamic response of the middle and upper floors were much more apparent after the test. Moreover, 3D numerical simulation models of the tested tower were established and validated against the test responses. Successively, the validated numerical model was used to investigate the influence of the transition column at different floors on the peak interstory drift response and the relevant strain distribution, and the proposal for a proper position of the transition column was recommended at the end.
Feldversuch zum Rüttelstopfsäuleneinbau und Betrachtungen zur Hohlraumaufweitung
Authors: Mugele Luis , Knittel Lukas , Osinov Vladimir , Pandrea Paul , Stutz Hans Henning 
Published: May 2024

AbstractDie Rüttelstopfverdichtung kommt als Baugrundverbesserung weltweit in fein‐ und grobkörnigen Böden zum Einsatz. Jedoch sind die Zustandsänderungen des anstehenden Bodens infolge des vollverdrängenden Säuleneinbaus und der induzierten Vibration noch nicht ausreichend untersucht. Im ersten Teil dieses Beitrags werden daher in einem Feldversuch die Auswirkungen der Rüttelstopfsäulenherstellung auf den Zustand des anstehenden Bodens untersucht. Dabei zeigt sich, dass der Rüttelstopfsäuleneinbau in grobkörnigen Böden zu einer Verbesserung der bautechnischen Eigenschaften des anstehenden Bodens führen kann. Motiviert durch den Feldversuch betrachtet der zweite Teil der Arbeit anhand von simplifizierten Beispielen einen grundsätzlichen Vergleich verschiedener Hohlraumaufweitungsprozesse. Mithilfe eines hypoplastischen Stoffmodells wird dabei die Aufweitung eines Hohlraums infolge (1) einer monotonen und infolge (2) einer zyklischen Belastung betrachtet. Beide Fälle werden im Hinblick auf eine qualitative Übertragbarkeit auf die Modellierung der Säuleninstallation verglichen. Es zeigt sich ein qualitativ unterschiedliches Bodenverhalten: Eine monotone Aufweitung führt zum kritischen Zustand im Boden, während eine zyklische Aufweitung in Abhängigkeit von der Durchlässigkeit zu einer Verdichtung und/oder einer Spannungsrelaxation führt. Eine vollständige Vernachlässigung der Rüttlervibration in entsprechenden numerischen Modellen erscheint daher nicht zutreffend.
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Authors: Yu Yue , Sun Fei‐Ji 
Published: May 2024

AbstractEpilepsy is an abnormal neurologic disorder distinguished by the recurrent manifestation of seizures, and the precise underlying mechanisms for its development and progression remain uncertain. In recent years, the hypothesis that inflammatory mediators and corresponding pathways contribute to seizures has been supported by experimental results. The potential involvement of neuroinflammation in the development of epilepsy has garnered growing interest. This review centers attention on the involvement of inflammatory mediators in the emergence and progression of epilepsy within recent years, focusing on both clinical research and animal models, to enhance comprehension of the intricate interplay between brain inflammation and epileptogenesis.
Extracellular vesicles in skin health, diseases, and aging
Authors: Wang Juan , Yuan Siqi , Tu Yidong , Lv Zhi , Cheng Hua , Ding Xiaolei 
Published: May 2024

AbstractThe skin interfaces with the external environment, acting as both a physical barrier and an immunologic defense. The dynamic interactions between various cell types are essential for skin homeostasis and function. Emerging research has unveiled the significant role of extracellular vesicles (EVs) as key mediators of cell communication in regulating many aspects of skin physiological and pathological processes. In this review, we provide an overview of recent advances in understanding the physiological and pathological roles of EVs in skin health, aging, and diseases, and discuss natural and engineered EVs in skin disease treatment along with the potential challenges. The burgeoning area of EVs may expand new therapeutic approaches for various skin disorders and open new avenues for personalized skincare treatments.
Exploring the interplay between triple‐negative breast cancer stem cells and tumor microenvironment for effective therapeutic strategies
Authors: Zou Zhuoling , Luo Tinglan , Wang Xinyuan , Wang Bin , Li Qing 
Published: May 2024

AbstractTriple‐negative breast cancer (TNBC) is a highly aggressive and metastatic malignancy with poor treatment outcomes. The interaction between the tumor microenvironment (TME) and breast cancer stem cells (BCSCs) plays an important role in the development of TNBC. Owing to their ability of self‐renewal and multidirectional differentiation, BCSCs maintain tumor growth, drive metastatic colonization, and facilitate the development of drug resistance. TME is the main factor regulating the phenotype and metastasis of BCSCs. Immune cells, cancer‐related fibroblasts (CAFs), cytokines, mesenchymal cells, endothelial cells, and extracellular matrix within the TME form a complex communication network, exert highly selective pressure on the tumor, and provide a conducive environment for the formation of BCSC niches. Tumor growth and metastasis can be controlled by targeting the TME to eliminate BCSC niches or targeting BCSCs to modify the TME. These approaches may improve the treatment outcomes and possess great application potential in clinical settings. In this review, we summarized the relationship between BCSCs and the progression and drug resistance of TNBC, especially focusing on the interaction between BCSCs and TME. In addition, we discussed therapeutic strategies that target the TME to inhibit or eliminate BCSCs, providing valuable insights into the clinical treatment of TNBC.
Forecasting fish mortality from water and air quality data using deep learning models
Authors: Ting Chia‐Ching , Chen Ying‐Chu 
Published: May 2024

AbstractThe high rate of aquatic mortality incidents recorded in Taiwan and worldwide is creating an urgent demand for more accurate fish mortality prediction. Present study innovatively integrated air and water quality data to measure water quality degradation, and utilized deep learning methods to predict accidental fish mortality from the data. Keras library was used to build multilayer perceptron and long short‐term memory models for training purposes, and the models’ accuracies in fish mortality prediction were compared with that of the naïve Bayesian classifier. Environmental data from the 5 days before a fish mortality event proved to be the most important data for effective model training. Multilayer perceptron model reached an accuracy of 93.4%, with a loss function of 0.01, when meteorological and water quality data were jointly considered. It was found that meteorological conditions were not the sole contributors to fish mortality. Predicted fish mortality rate of 4.7% closely corresponded to the true number of fish mortality events during the study period, that is, four. A significant surge in fish mortality, from 20% to 50%, was noted when the river pollution index increased from 5.36 to 6.5. Moreover, the probability of fish mortality increased when the concentration of dissolved oxygen dropped below 2 mg/L. To mitigate fish mortality, ammonia nitrogen concentrations should be capped at 5 mg/L. Dissolved oxygen concentration was found to be the paramount factor influencing fish mortality, followed by the river pollution index and meteorological data. Results of the present study are expected to aid progress toward achieving the Sustainable Development Goals and to increase the profitability of water resources.
Prognostic Value of MRI Assessment of Residual Peritumoral Edema in Breast Cancer Treated With Neoadjuvant Chemotherapy
Authors: Shigematsu Hideo , Fujimoto Mutsumi , Kobayashi Yoshie , Yasui Daisuke , Komoto Daisuke , Matsuura Noriaki , Kuraoka Kazuya , Yoshiyama Tomoyuki 
Published: May 2024

BackgroundPeritumoral edema (PE) identified on T2‐weighted breast MRI is a factor for poor prognosis in breast cancer.PurposeTo assess the prognostic value of residual PE (rPE) in patients with PE positive breast cancer prior to neoadjuvant chemotherapy (NACT) who subsequently underwent curative surgery.Study TypeRetrospective.PopulationIn total, 128 patients with nonmetastatic invasive breast cancer who underwent breast MRI before and after NACT.Field Strength/SequenceAxial precontrast 2D fast spin echo T2W fat‐suppressed sequence. Axial dynamic 3D gradient echo T1W fat‐suppressed sequence.AssessmentPE was diagnosed when a signal intensity as high as water was detected surrounding the tumor on a T2‐weighted breast MRI. PE was qualitatively evaluated by three readers with more than 20 years of experience in interpreting breast field imaging findings. Residual cancer burden (RCB) were assessed post‐NACT. Recurrence‐free survival (RFS) and overall survival (OS) were evaluated as the endpoints of this study.Statistical TestsChi‐square test; Kaplan–Meier method, log‐rank test, and Cox proportional hazard model. A P‐value <0.05 was considered statistically significant.ResultsPre‐PE was observed in 64 out of 128 patients. Of these, rPE was observed in 21. In the log‐rank test, breast cancer with rPE had significantly worse RFS and OS than that without rPE. Cox proportional hazard analysis identified rPE as a significant prognostic factor for recurrence (hazard ratio, 11.6; 95% confidence interval [CI], 3.05–43.8) and death (hazard ratio, 17.8; 95% CI, 3.30–96.3). Breast cancer with rPE had significant worse RFS and OS than that without rPE in RCB class II, and significant worse OS in pathological complete response, class I and class II in the log‐rank test.Data ConclusionrPE on a T2‐weighted breast MRI was a significant factor for breast cancer recurrence and death in patients with pre‐PE‐positive breast cancer treated with NACT.Level of Evidence3.Technical EfficacyStage 2.
Meaning in life among emerging adults: An examination of gender, relationship status, and social media use
Authors: Karayigit Cebrail , Ozier Michaela , Bloom Amber , Weaver Mark , Wiltz Samantha 
Published: May 2024

AbstractUsing a sample of 450 emerging adult university students, this study examined the effects of relationship status and gender on meaning in life (MIL) dimensions and the relationship between social media use and MIL dimensions among participants. The MIL Questionnaire (MLQ) and a subscale of the Sources of Meaning and MLQ (SoMe) were used to measure three different life meaning dimensions (presence of meaning, search for meaning, and crises of meaning). Findings suggested that being in a romantic relationship is positively associated with the presence of MIL. Findings also revealed that the time spent on social media and social media satisfaction affects MIL dimensions. Implications for counselors and other mental health professionals are presented and have the potential to impact college students’ MIL issues.
Percutaneous radiologic gastrostomy versus percutaneous endoscopic gastrostomy for enteral feeding: A systematic review and meta‐analysis
Authors: Meine Matheus Coelho , Tusato Isabela Ho , Hoffmeister Nathalia , Meine Gilmara Coelho 
Published: May 2024

AbstractBackgroundPercutaneous radiological gastrostomy (PRG) and percutaneous endoscopic gastrostomy (PEG) are minimally invasive gastrostomy techniques for individuals requiring prolonged enteral feeding. Recent meta‐analyses concerning their efficacy and safety mainly included retrospective studies and yielded conflicting results. This meta‐analysis of randomized controlled trials (RCTs) aimed to compare efficacy, safety, and procedure time between PRG and PEG for enteral feeding.MethodsMEDLINE, Embase, and the Cochrane Library were searched for eligible RCTs comparing PRG and PEG for enteral feeding through February 23, 2024. The primary outcome was technical success. The secondary outcomes were (1) adverse events (AEs), (2) mortality, and (3) procedure time. We used the random‐effects model to calculate pooled risk ratio (RR) and mean difference (MD) with corresponding 95% CIs for dichotomous and continuous outcomes, respectively.ResultsFive RCTs with 544 patients (268 PRG and 276 PEG) were included. There was similar technical success (RR = 1.02; 95% CI = 0.98–1.05; I² = 35%; moderate certainty of evidence because of inconsistency), overall mortality (RR = 1.25; 95% CI = 0.63–2.47; I² = 47%; very low certainty of evidence because of inconsistency, indirectness, and imprecision), and overall AEs risk (RR = 1.06; 95% CI = 0.63–1.76; I² = 81%; low certainty of evidence because of inconsistency and imprecision) between the two groups. However, compared with PEG, the procedure time was longer in the PRG group (MD = 19.35 min; 95% CI = 0.95–37.75 min; I² = 98%; very low certainty of evidence because of inconsistency and imprecision).ConclusionPRG and PEG demonstrate similar efficacy and safety; however, the endoscopic technique may boast a shorter procedure time.
Growth charts for use at birth and in the neonatal period: Recommendations of the French Neonatal Society
Authors: Guellec Isabelle , Simon Laure , Vayssiere Christophe , Senat Marie‐Victoire , Ego Anne , Zeitlin Jennifer , Subtil Damien , Verspyck Eric , Lapillonne Alexandre , Roze Jean‐Christophe , Claris Olivier , Picaud Jean‐Charles , Monier Isabelle , Geraldine Gascoin 
Published: May 2024

AbstractIntroductionThe use of different growth charts can lead to confusion in discussions between professionals. There are obstetric charts (of fetal growth) and neonatal charts (of measurements at birth and of postnatal growth). These charts can be descriptive (derived from an unselected population) or prescriptive (derived from of a population at low risk and with optimal conditions for growth).Objectives(1) To describe available charts for infants at birth and in the neonatal period and compare them, and (2) to recommend one or more charts for use in neonatology in France.MethodsBibliographic research was conducted on MEDLINE and completed by the guidelines of professional societies.ResultsAntenatal information about fetal growth restriction or fetuses identified as small‐for‐gestational‐age using Intrauterine charts must be integrated into the identification of newborns at risk, but the use of Intrauterine charts to evaluate birthweight is not recommended to allow consistency with postnatal charts used in neonatal practice. Z‐score variations using the updated Fenton postnatal charts are the most appropriate for the assessment of birthweight and postnatal growth for infants born preterm. These charts are sex‐specific, include the three measurements (length, weight, and head circumference) and enable longitudinal follow‐up of growth up to 50 weeks of corrected age and are linked to the World Health Organization charts at term. The French Audipog charts, although are individualized, accessible online and can be used in maternity units to evaluate birthweight for term infants, but do not allow the follow‐up of postnatal growth, while Fenton charts may be used to evaluate birthweight and postnatal growth in the first month for hospitalized term infants.ConclusionThe updated Fenton charts are the neonatal charts that best suit the objectives of pediatricians in France for monitoring the growth of preterm newborns. The use of the Audipog charts at term remains an alternative in maternity wards, while Fenton charts can be used for hospitalized term newborns.
Natural History of Untreated Idiopathic Sudden Sensorineural Hearing Loss
Authors: Ying Yu‐Lan Mary , Tseng Christopher C. , Shin Jennifer , Rauch Steven 
Published: May 2024

ObjectiveAlthough corticosteroids and other treatments for idiopathic sudden sensorineural hearing loss (ISSNHL) have been described, understanding its prognosis without intervention provides valuable information for patient management. The objective of this study is to provide a comprehensive, quantitative statistical analysis of the natural history of untreated idiopathic sudden sensorineural hearing loss (ISSNHL).Study Type and DesignA systematic review and meta‐analyses.MethodsTwo independent searches of PubMed, Scopus, Web of Science, and Cochrane Library databases up to June 30, 2022, were performed. Adults with idiopathic sudden sensorineural hearing loss who received placebo or were untreated and had audiometric outcome measures in all study types were reviewed. These data indicative of the natural history of ISSNHL were analyzed, as were study characteristics related to risk of bias. Heterogeneity as assessed viaI2and random effects analyses were performed.ResultsSix studies meeting the inclusion criteria yielded 319 untreated patients whose natural history could be assessed. Heterogeneity among studies was moderate, with a variety of reported outcomes. A hearing improvement of at least 30 dB HL was observed in 36% (95% CI 0.28–0.44) of untreated patients, and of at least 10 dB HL was observed in 70% (95% CI 0.57–0.82) of untreated patients at 3 months. The mean hearing gain among untreated patients was 24.0 dB HL (95% CI 2.65–45.37) at 2–3 months.ConclusionsThe observed natural history of ISSNHL suggests that patients can regain some hearing without active treatment. In the absence of future studies collecting prospective natural history data from untreated or placebo‐treated ISSNHL patients, the data presented here provide the best available historical control data for reconsideration of results in past ISSNHL studies, as well as a roadmap for design and interpretation of future ISSNHL treatment clinical trials. Furthermore, knowing there is a statistically significant mean hearing gain of 24.0 dB HL in the untreated/placebo group provides an ethical basis for future placebo study of ISSNHL. The current status on ISSNHL management calls for a multi‐institutional, randomized, double‐blind placebo‐controlled trial with validated outcome measures to provide science‐based treatment guidance.Laryngoscope, 134:S1–S15, 2024
Microenvironment‐Responsive Hydrogel Reduces Seizures After Traumatic Brain Injury in Juvenile Rats by Reducing Oxidative Stress and Hippocampal Inflammation
Authors: Han Zhengzhong , Zhao Zeqi , Yu Hao , Wang Lansheng , Yue Chenglong , Zhu Bingxin , Zhu Yongqi , Li Zhengwei , Sha Zhuang 
Published: May 2024

AbstractTraumatic brain injury (TBI) is the primary cause of child mortality and disability worldwide. It can result in severe complications that significantly impact children's quality of life, including post‐traumatic epilepsy (PTE). An increasing number of studies suggest that TBI‐induced oxidative stress and neuroinflammatory sequelae (especially, inflammation in the hippocampus region) may lead to the development of PTE. Due to the blood–brain barrier (BBB), typical systemic pharmacological therapy for TBI cannot deliver berberine (BBR) to the targeted location in the early stages of the injury, although BBR has strong anti‐inflammatory properties. To break through this limitation, a microenvironment‐responsive gelatin methacrylate (GM) hydrogel to deliver poly(propylene sulfide)60 (PPS60) and BBR (GM/PB) is developed for regulating neuroinflammatory reactions and removing reactive oxygen species (ROS) in the brain trauma microenvironment through PPS60. In situ injection of the GM/PB hydrogel efficiently bypasses the BBB and is administered directly to the surface of brain tissue. In post‐traumatic brain injury models, GM/PB has the potential to mitigate oxidative stress and neuroinflammatory responses, facilitate functional recovery, and lessen seizing. These findings can lead to a new treatment for brain injuries, which minimizes complications and improves the quality of life.
3D Porous Binary Composites of Collagen, Elastin, and Fibrin Proteins Orchestrate Adipose Tissue Regeneration
Authors: Sawadkar Prasad , Mandakhbayar Nandin , Patel Kapil D , Owji Nazanin , Rajasekar Poojitha , Sarama Roudin , Lee Jung‐Hwan , Kim Hae‐Won , Knowles Jonathan , García‐Gareta Elena 
Published: May 2024

AbstractThe objective for this study is to advance the development of a specialized biomaterial that can effectively facilitate the regeneration of adipose tissue. In prior studies, the assessment of collagen (Col), elastin (Ela), and fibrin (Fib) unary scaffolds has been conducted. However, it is important to note that native adipose tissue is comprised of a diverse array of extracellular matrix (ECM) constituents. To mimic this behavior, binary compositions of collagen, elastin, and fibrin are fabricated in a 1:1 ratio, resulting in the formation of Col/Ela, Col/Fib, and Ela/Fib composites through a customized fabrication procedure. The physical properties of these scaffolds are comprehensively analyzed using a range of material characterization techniques. Additionally, the biological properties of the scaffolds are investigated by examining the survival, proliferation, and phenotype of adipose‐derived stem cells. Subsequently, the aforementioned binary scaffolds are implanted into a rodent model for 28 days. the explants are analysed through X‐ray microtomography, histology, and immunohistochemistry. The findings of the study demonstrate that the utilization of binary combinations of Col/Ela, Col/Fib, and Ela/Fib has a discernible impact on the physical and biological characteristics of the scaffolds. Nevertheless, Ela/Fib exhibits characteristics that make it a suitable candidate for adipogenesis due to its notable upregulation of caveolin‐1 expression in both acellular and cellular cohorts. The combination of two natural polymers in this cell–material interaction has significantly enhanced the comprehension of adipogenesis.