bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Asymmetric Three‐Component Inverse Electron‐Demand Aza‐Diels—Alder Reaction: Efficient Synthesis of Ring‐Fused Tetrahydroquinolines.
Authors: Xie Mingsheng , Chen Xiaohong , Zhu Yin , Gao Bo , Lin Lili , Liu Xiaohua , Feng Xiaoming 
Published: September 2010

AbstractThe reaction of aromatic and aliphatic aldehydes, 2‐aminophenols and cyclopentadiene (III) is catalyzed by Sc(OTf)3 and a chiral N,N′‐dioxide catalysts to afford the target tricyclic products with high yields and selectivities.
ChemInform Abstract: Synthesis and Spectral Properties of 4‐Amino‐ and 4‐Acetylamino‐N‐arylnaphthalimides Containing Electron‐Donating Groups in the N‐Aryl Substituent.
Authors: Panchenko P. A. , Fedorov Yu. V. , Fedorova O. A. , Perevalov V. P. , Jonusauskas G. 
Published: September 2010

AbstractIt is shown that introduction of electron‐donating alkoxy groups into the benzene ring of the N‐aryl fragment leads to fluorescence quenching of the naphthalimide chromophore.
ChemInform Abstract: Bicyclic Compounds Obtained by the Biginelli Reaction.
Authors: Kurbanova M. M. 
Published: September 2010

AbstractThree‐component reaction of 5‐bromosalicylaldehyde (I) with 1,3‐dicarbonyl compounds (II) and urea derivatives (III) gives the expected pyrimidine derivatives (IV) or bicyclic compounds (V) depending on the reaction conditions.
ChemInform Abstract: Fluorine‐Containing Quinazolines Annulated at the Pyrimidine Ring.
Authors: Nosova E. V. , Laeva A. A. , Trashakhova T. V. , Lipunova G. N. , Slepukhin P. A. , Charushin V. N. 
Published: September 2010

AbstractThe title compounds are synthesized by the reaction of 2‐ and 4‐hydrazino‐substituted quinazolines with aldehydes and subsequent oxidative cyclization or by alkylation of 2‐alkylthio‐4(3H)‐quinazolinones with bromoethanol and ipso‐substitution of the alkylthio group.
ChemInform Abstract: The Asymmetric Synthesis of Sitagliptin, a Selective Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes.
Authors: Liu Feng , Yu Wansheng , Ou Wenhua , Wang Xiaoke , Ruan Libo , Li Yiming , Peng Xijiang , Tao Xiaohu , Pan Xianhua 
Published: September 2010

AbstractKey step in the improved synthetic pathway to sitagliptin (VII), a new DPP‐IV inhibitor for the treatment of type 2 diabetes mellitus, is an asymmetric Michael addition to give intermediate (IV).
ChemInform Abstract: Synthesis and Antiproliferative Activity of Oxazinocarbazole and N,N‐Bis(carbazolylmethyl)amine Derivatives.
Authors: Issa Samar , Walchshofer Nadia , Kassab Issam , Termoss Hussein , Chamat Soulaima , Geahchan Aziz , Bouaziz Zouhair 
Published: September 2010

AbstractTwentyfour oxazinocarbazoles (IV) are prepared by a Mannich type condensation of N‐substituted hydroxycarbazoles (I) with formaldehyde (II) and primary amines (III).
ChemInform Abstract: Silver‐Catalyzed Tandem Ammonolysis—Cyclization of 2‐Alkynylbenzenamines with Tetraalkylthiuram Disulfides to 4‐Methylene‐4H‐benzo[d][1,3]thiazin‐2‐amines.
Authors: Tang Ri‐Yuan , Luo Pei‐Song , Zhang Xing‐Guo , Zhong Ping , Li Jin‐Heng 
Published: September 2010

AbstractDisulfides (IIa) and (IIb) afford exclusively the (Z)‐products on reaction with substrate (Ia/Ib).
ChemInform Abstract: Synthesis and Biological Evaluation of New [1,2,4]Triazino[5,6‐b]indol‐3‐ylthio‐1,3,5‐triazines and [1,2,4]Triazino[5,6‐b]indol‐3‐ylthio‐pyrimidines Against Leishmania donovani.
Authors: Gupta Leena , Sunduru Naresh , Verma Aditya , Srivastava Saumya , Gupta Suman , Goyal Neena , Chauhan Prem M. S. 
Published: September 2010

AbstractTriazinoindoletriazine derivatives (VII) and triazinopyrimidine derivatives (X) are synthesized via cyclization of protected isatin (I) with thiosemicarbazide (II) and nucleophilic substitution of intermediates (V) and (IX) with amines, e.g. (VI).
ChemInform Abstract: Ester‐Directed Regioselective Borylation of Heteroarenes Catalyzed by a Silica‐Supported Iridium Complex.
Authors: Kawamorita Soichiro , Ohmiya Hirohisa , Sawamura Masaya 
Published: September 2010

AbstractHeteroarenes bearing an ester substituent undergo regioselective borylation at the position adjacent to the ester group.
ChemInform Abstract: Polyfused Nitrogen‐Containing Heterocycles. Part 23. Methyl 4‐Hydroxy‐3‐phenyl‐5‐phenyl (alkyl)‐2‐phenyliminoselenazolidine‐4‐carboxylates and Selenazolo[3,4‐a]quinoxalin‐4(5H)‐one Derivatives on Their Basis.
Authors: Mamedov V. A. , Zhukova N. A. , Gubaidullin A. T. , Beschastnova T. N. , Rizvanov I. Kh. , Levin Ya. A. , Litvinov I. A. 
Published: September 2010

AbstractThe condensation of halopyrotartrates (I) with N,N′‐diphenylselenourea (II) leads to carboxylates (III) which undergo reaction with various 1,2‐phenylenediamines giving selenazolo[3,4‐a]quinoxalin‐4(5H)‐one derivatives.
ChemInform Abstract: Synthesis and Evaluation of 9‐Benzylideneamino Derivatives of Homocamptothecin as Potent Inhibitors of DNA Topoisomerase I.
Authors: Miao Zhenyuan , et al. et al. 
Published: September 2010

AbstractFriedlaender cyclization of the previously described key intermediate (II) with acetamide (I) and reaction of (IV) with substituted benzaldehydes (V) afford thirteen novel benzylideneamino derivatives of homocamptothecin.
ChemInform Abstract: Concise Formal Synthesis of (‐)‐Salinosporamide A (Marizomib) (IV) Using a Regio‐ and Stereoselective Epoxidation and Reductive Oxirane Ring‐Opening Strategy.
Authors: Ling Taotao , Potts Barbara C. , Macherla Venkat R. 
Published: September 2010

AbstractThe key steps are stereoselective epoxidation of the alkene (I) and subsequent regio‐ and stereoselective oxirane ring‐opening.
ChemInform Abstract: Efficient Total Synthesis of (S)‐14‐Azacamptothecin.
Authors: Liu Guan‐Sai , Yao Yuan‐Shan , Xu Peng , Wang Shaozhong , Yao Zhu‐Jun 
Published: September 2010

AbstractA mild Hendrickson reagent triggered intramolecular cascade cyclization, a highly enantioselective dihydroxylation, and an efficient palladium‐catalyzed migration of O‐allyl to N‐allyl are employed as the key steps in this work.
ChemInform Abstract: (—)‐Carbodine: Enantiomeric Synthesis and in vitro Antiviral Activity Against Various Strains of Influenza Virus Including H5N1 (Avian Influenza) and Novel 2009 H1N1 (Swine Flu).
Authors: Rao Jagadeeshwar R. , Jha Ashok K. , Rawal Ravindra K. , Sharon Ashoke , Day Craig W. , Barnard Dale L. , Smee Donald F. , Chu Chung K. 
Published: September 2010

AbstractThe enantiomerically pure cyclopentyl cytosine, (‐)‐carbodine (VI), is synthesized and evaluated for its in vitro antiinfluenza activity in comparison to its racemate and (+)‐enantiomer.
ChemInform Abstract: Synthesis of 1H‐Indole‐2,3‐dione‐3‐thiosemicarbazone Ribonucleosides as Antibacterial Agents.
Authors: Kassab Shaymaa E. , Hegazy Gehan H. , Eid Nahed M. , Amin Kamelia M. , El‐Gendy Adel A. 
Published: September 2010

AbstractAll synthesized compounds exhibit slight inhibitory activity against some bacterial strains.
ChemInform Abstract: Efficient Synthesis of Clofarabine and Gemcitabine from 2‐Deoxyribonolactone.
Authors: Cen Yana , Sauve Anthony A. 
Published: September 2010

AbstractNew syntheses of clofarabine (VI) and gemcitabine (X) based on a previously described electrophilic fluorination method for the synthesis of 2‐fluoro furanose derivatives are described.
ChemInform Abstract: Pyrimidine‐Purine and Pyrimidine Heterodinucleosides Synthesis Containing a Triazole Linkage.
Authors: Lucas R. , Elchinger P. H. , Faugeras P. A. , Zerrouki R. 
Published: September 2010

AbstractThe triazole heterodimers (V) and (VIII) are synthesized involving a click chemistry reaction and microwave irradiation.
ChemInform Abstract: Synthesis and Molecular Docking Studies of 1‐Phenyl‐4‐glycosyl‐dihydropyridines as Potent Antileishmanial Agents.
Authors: Pandey Vivek Parashar , Bisht Surendra Singh , Mishra Mridul , Kumar Ashutosh , Siddiqi Mohammad Imran , Verma Aditya , Mittal Monika , Sane Shraddha A. , Gupta Suman , Tripathi Rama P. 
Published: September 2010

AbstractThe one‐pot multicomponent reaction of xylofuranosyl dialdoses (I) with β‐keto compounds (II) and anilines (III) affords the pentofuranosyldihydropyridines (IV) in good yields.
ChemInform Abstract: Enantioselective Synthesis of (1E,3S)‐1‐Iodoundec‐1‐en‐5‐yn‐3‐ol (III), the Eicosanoid Synthon
Authors: Lapitskaya M. A. , Vasiljeva L. L. , Pivnitsky K. K. 
Published: September 2010

Abstractbased on the S‐enantiodirected dihydroxylation of enyne (I)
ChemInform Abstract: Formal Total Syntheses of (+)‐Prelaureatin (IV) and (+)‐Laurallene (V) by Diastereoselective Brook Rearrangement Mediated [3 + 4] Annulation.
Authors: Sasaki Michiko , Oyamada Kazuhisa , Takeda Kei 
Published: September 2010

AbstractThe synthesis of the title compounds is achieved via highly stereoselective cycloaddition of the silane (II) to the cyclic enone (I).
ChemInform Abstract: Enantioselective Synthesis of Iclaprim Enantiomers — A Versatile Approach to 2‐Substituted Chiral Chromenes.
Authors: Tahtaoui Chouaib , Demailly Arnold , Guidemann Carole , Joyeux Cecile , Schneider Peter 
Published: September 2010

AbstractThe synthesis of (R)‐iclaprim (VI) and its (S) enantiomer is achieved via Mitsunobu reaction of alcohols (I) with the phenol (II) and novel cyclization of the aldehydes (IV).
ChemInform Abstract: Spectacular Modification of Gambogic Acid on Microwave Irradiation in Methanol: Isolation and Structure Identification of Two Products with Potent Antitumor Activity.
Authors: Wang Xiaojian , Lu Na , Yang Qian , Dai Qinsheng , Tao Lei , Guo Xiaoke , Guo Qinglong , You Qidong 
Published: September 2010

AbstractBoth the reaction products (III) and (IV) can significantly inhibit the growth of various tumor cell lines in vitro.
ChemInform Abstract: Allantopyrone A, a New α‐Pyrone Metabolite with Potent Cytotoxicity from an Endophytic Fungus, Allantophomopsis lycopodina KS‐97.
Authors: Shiono Yoshihito , Yokoi Miwa , Koseki Takuya , Murayama Tetsuya , Aburai Nobuhiro , Kimura Ken‐ichi 
Published: September 2010

AbstractCytotoxicity, and the preliminary apoptosis‐inducing activity of the new natural compound allantopyrone A (I) are described.
ChemInform Abstract: Phellinins B and C, New Styrylpyrones from the Culture Broth of Phellinus sp.
Authors: Lee In‐Kyoung , Jung Jin‐Young , Kim Young‐Ho , Yun Bong‐Sik 
Published: September 2010

AbstractTwo new antioxidants, phellinin B, a mixture of (I) and (IIa), and C (IIb), are isolated from the culture broth of the title wood fungus.
ChemInform Abstract: Endothelial Modulation of Agonist‐Induced Vasoconstriction in Mesenteric Microcirculation
Authors: Jin Xin , Otonashi‐Satoh Yukiko , Zamami Yoshito , Koyama Toshihiro , Sun Pengyuan , Kitamura Yoshihisa , Kawasaki Hiromu 
Published: September 2010

AbstractReview: 28 refs.
ChemInform Abstract: Beginning of Open Use of a New Biological Neutron Diffractometer (iBIX) in J‐PARC
Authors: Tanaka Ichiro , Kusaka Katsuhiro , Hosoya Takaaki , Ohhara Takashi , Kurihara Kazuo , Niimura Nobuo 
Published: September 2010

AbstractReview: 13 refs.
ChemInform Abstract: Pharmaceutical Food Science: Search for anti‐Obese Constituents from Medicinal Foods — anti‐Hyperlipidemic Saponin Constituents from the Flowers of Bellis perennis
Authors: Morikawa Toshio , Muraoka Osamu , Yoshikawa Masayuki 
Published: September 2010

AbstractReview: 29 refs.
Rotational strength sign and normal modes description: A theoretical and experimental comparative study in bicyclic terpenes
Authors: Partal Ureña Francisco , Avilés Moreno Juan Ramón , López González Juan Jesús 
Published: September 2010

AbstractA comparative study of the Vibrational circular dichroism (VCD) patterns in three bicyclic terpenes with related molecular structures, (+)‐(R)‐α‐pinene, (−)‐(S)‐β‐pinene, and (−)‐(S)‐verbenone, is carried out. The study is done in the light of normal mode descriptions from a previous vibrational analysis. Although normal modes corresponding to identical molecular moieties shown the same description, rotational strength does not follow the Cahn‐Ingold‐Prelog descriptor‐related sign in some cases, i.e., they do not present opposite signs depending on stereochemical description of the molecule. Chirality, 2010. © 2010 Wiley‐Liss, Inc.
Cytochrome p450‐dependent disposition of the enantiomers of citalopram and its metabolites: In vivo studies in Sprague‐Dawley and Dark Agouti rats
Authors: Kingbäck Maria , Carlsson Björn , Ahlner Johan , Bengtsson Finn , Kugelberg Fredrik C. 
Published: September 2010

AbstractThe female Sprague‐Dawley (SD) and Dark Agouti (DA) rats are considered the animal counterparts of the human extensive and poor metabolizer cytochrome P450 (CYP) 2D6 phenotypes, respectively. The aim of this work was to study possible rat strain differences in the steady‐state pharmacokinetics of the (+)‐(S)‐ and (−)‐(R)‐enantiomers of citalopram and its demethylated metabolites. A chronic drug treatment regimen (15 mg/kg daily) was implemented for 13 days in separate groups of SD (n= 9) and DA (n= 9) rats by using osmotic pumps. The concentrations of citalopram and two major metabolites in serum and two brain regions were analyzed by an enantioselective high‐performance liquid chromatography assay. Higher serum and brain levels of citalopram and demethylcitalopram, but lower levels of didemethylcitalopram, were observed in DA rats when compared with SD rats. The enantiomeric (S/R) concentrations ratios of citalopram were lower in the DA rats when compared with the SD rats (0.53 ± 0.05 vs. 0.80 ± 0.03,P< 0.001), indicating a possibly decreased capacity in the metabolism of the (−)‐(R)‐enantiomer in the DA rats. This study shows that CYP2D deficiency results in steady‐state pharmacokinetic differences of the enantiomers of citalopram and its metabolites. Chirality, 2011. © 2010 Wiley‐Liss, Inc.
Pressure Loss – Educational Experiments for Microreaction Technology using an Universal Experiment Platform
Authors: Groß A. , Schneider S. , Abahmane L. , Köhler J. M. 
Published: September 2010

AbstractDuring the recent decade, microreaction technologies became an established technique for research and development purposes as well as industrial production. The superior advantages in terms of process intensification by enhanced heat and mass transfer as well as process control and safety issues lead to a growing need for scientists with microreaction technology experiences. The pressure loss and energy dissipation of fluids flowing in microdevices are the most important procedural basis. Pressure loss effects have to be taken into account for the layout of microsystems as well as the assembly of different microfluidic devices. Furthermore, the pressure loss is a quite sensitive parameter for changes in the hydrodynamic diameter of the used microdevices which may vary by production tolerances or fouling processes. Here, some educational experiments for experimental teaching of basic pressure loss principles in microdevices are presented.
Organization of somatosensory cortex in the Northern grasshopper mouse (Onychomys leucogaster), a predatory rodent
Authors: Sarko Diana K. , Leitch Duncan B. , Girard Isabelle , Sikes Robert S. , Catania Kenneth C. 
Published: September 2010

AbstractNorthern grasshopper mice (Onychomys leucogaster) are among the most highly carnivorous rodents in North America. Because predatory mammals may have specialization of senses used to detect prey, we investigated the organization of sensory areas within grasshopper mouse neocortex and quantified the number of myelinated axons in grasshopper mouse trigeminal, cochlear, and optic nerves. Multiunit electrophysiological recordings combined with analysis of flattened sections of neocortex processed for cytochrome oxidase were used to determine the topography of primary somatosensory cortex (S1) and the location and size of both the visual and auditory cortex in adult animals. These findings were then related to the distinctive chemoarchitecture of layer IV visible in flattened cortical sections of juvenile grasshopper mice labeled with the serotonin transporter (SERT) antibody, revealing a striking correspondence between electrophysiological maps and cortical anatomy. J. Comp. Neurol. 519:64‐74, 2011. © 2010 Wiley‐Liss, Inc.
Characterization of the dopaminergic system in the brain of an African cichlid fish,Astatotilapia burtoni
Authors: O'Connell Lauren A. , Fontenot Miles R. , Hofmann Hans A. 
Published: September 2010

AbstractCatecholamines, such as dopamine, are evolutionarily ancient neurotransmitters that play an essential role in mediating behavior. In vertebrates, dopamine is central to the nigrostriatal motor and mesolimbic reward systems. Despite its importance, the distribution of the dopaminergic system has not been well studied in the teleost brain. The African cichlid fishAstatotilapia burtonihas become an important model system in social neuroscience and lends itself to uncovering how social decisions are implemented in the brain. To understand better where dopamine acts to regulate social behavior in this species, we have determined the distribution of putative dopaminergic cells and fibers (by tyrosine hydroxylase immunohistochemistry) and dopamine receptors (by in situ hybridization for the D1Aand D2dopamine receptor subtypes) throughout the forebrain and part of the mesencephalon ofA. burtoni. Tyrosine hydroxylase immunoreactivity was evident in several regions of the fore‐ and midbrain, in support of putative homologies to tetrapods. Additionally, the D1Aand D2receptors were identified in brain regions known to modulate social behavior in other vertebrates, including the proposed teleost homologues of the mammalian amygdalar complex, hippocampus, striatum, preoptic area, anterior hypothalamus, ventromedial hypothalamus, and ventral tegmental area/substantia nigra pars compacta. Tyrosine hydroxylase‐immunoreactive fibers as well as D1Aand D2receptor expression overlap almost completely in their distribution. These results significantly extend our understanding of the distribution of the dopaminergic system in the teleost brain and suggest a conserved role of dopamine in modulating behavior across vertebrates. J. Comp. Neurol. 519:75‐92, 2011. © 2010 Wiley‐Liss, Inc.
Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane
Authors: Verpy Elisabeth , Leibovici Michel , Michalski Nicolas , Goodyear Richard J. , Houdon Carine , Weil Dominique , Richardson Guy P. , Petit Christine 
Published: September 2010

AbstractStereocilin is defective in a recessive form of deafness, DFNB16. We studied the distribution of stereocilin in the developing and mature mouse inner ear and analyzed the consequences of its absence in stereocilin‐null (Strc−/−) mice that suffer hearing loss starting at postnatal day 15 (P15) and progressing until P60. Using immunofluorescence and immunogold electron microscopy, stereocilin was detected in association with two cell surface specializations specific to outer hair cells (OHCs) in the mature cochlea: the horizontal top connectors that join the apical regions of adjacent stereocilia within the hair bundle, and the attachment links that attach the tallest stereocilia to the overlying tectorial membrane. Stereocilin was also detected around the kinocilium of vestibular hair cells and immature OHCs. In Strc−/− mice the OHC hair bundle was structurally and functionally normal until P9. Top connectors, however, did not form and the cohesiveness of the OHC hair bundle progressively deteriorated from P10. The stereocilia were still interconnected by tip links at P14, but these progressively disappeared from P15. By P60 the stereocilia, still arranged in a V‐shaped bundle, were fully disconnected from each other. Stereocilia imprints on the lower surface of the tectorial membrane were also not observed in Strc−/− mice, thus indicating that the tips of the tallest stereocilia failed to be embedded in this gel. We conclude that stereocilin is essential to the formation of horizontal top connectors. We propose that these links, which maintain the cohesiveness of the mature OHC hair bundle, are required for tip‐link turnover. J. Comp. Neurol. 519:194‐210, 2011. © 2010 Wiley‐Liss, Inc.
Brain expression and song regulation of the cholecystokinin gene in the zebra finch (Taeniopygia guttata)
Authors: Lovell Peter V. , Mello Claudio V. 
Published: September 2010

AbstractThe gene encoding cholecystokinin (Cck) is abundantly expressed in the mammalian brain and has been associated with such functions as feeding termination and satiety, locomotion and self‐stimulation, the modulation of anxiety‐like behaviors, and learning and memory. Here we describe the brain expression and song regulation of Cck in the brain of the adult male zebra finch (Taeniopygia guttata), a songbird species. Using in situ hybridization we demonstrate that Cck is highly expressed in several discrete brain regions, most prominently the caudalmost portion of the hippocampal formation, the caudodorsal nidopallial shelf and the caudomedial nidopallium (NCM), the core or shell regions of dorsal thalamic nuclei, dopaminergic cell groups in the mesencephalon and pons, the principal nucleus of the trigeminal nerve, and the dorsal raphe. Cck was largely absent in song control system, a group of nuclei required for vocal learning and song production in songbirds, although sparse labeling was detected throughout the striatum, including song nucleus area X. We also show that levels of Cck mRNA and the number of labeled cells increase in the NCM of males and females following auditory stimulation with conspecific song. Double labeling further reveals that the majority of Cck cells, excluding those in the reticular nucleus of the thalamus, are non‐GABAergic. Together, these data provide the first comprehensive characterization of Cck expression in a songbird, and suggest a possible involvement of Cck regulation in important aspects of birdsong biology, such as perceptual processing, auditory memorization, and/or vocal‐motor control of song production. J. Comp. Neurol. 519:211‐237, 2011. © 2010 Wiley‐Liss, Inc.
Well‐posedness in smooth function spaces for moving‐boundary 1‐D compressible euler equations in physical vacuum
Authors: Coutand Daniel , Shkoller Steve 
Published: September 2010

AbstractThe free‐boundary compressible one‐dimensional Euler equations with moving physical vacuum boundary are a system of hyperbolic conservation laws that are both characteristic and degenerate. The physical vacuum singularity (or rate of degeneracy) requires the sound speed
$c^2= \gamma \rho^{ \gamma -1}$
to scale as the square root of the distance to the vacuum boundary and has attracted a great deal of attention in recent years. We establish the existence of unique solutions to this system on a short time interval, which are smooth (in Sobolev spaces) all the way to the moving boundary. The proof is founded on a new higher‐order, Hardy‐type inequality in conjunction with an approximation of the Euler equations consisting of a particular degenerate parabolic regularization. Our regular solutions can be viewed as degenerate viscosity solutions. © 2010 Wiley Periodicals, Inc.