bluuebunny/crossref_metadata_2025_split huggingface dataset:
Point-of-care potentials of lateral flow-based field screening for Mycoplasma bovis infections: a literature review
Authors: Fasogbon Ilemobayo V , Ondari Erick N , Deusdedit Tusubira , Rangasamy Loganathan , Krishnan Sasirekha , Aja Patrick M 
Published: May 2024

Abstract
Point-of-care (POC) field screening for tools for Mycoplasma bovis (M. bovis) is still lacking due to the requirement for a simple, robust field-applicable test that does not entail specialized laboratory equipment. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, this review identifies the methodologies that were retrieved based on our search strategy that have been reported for the diagnosis of m. bovis infection between 2014 and diagnostics. A search criterion was generated to curate 103 articles, which were reduced in number (to 46), following the screening guidelines of PRISMA. The 43 articles included in the study present 25 different assay methods. The assay methods were grouped as microbiological culture, serological assay, PCR-based assay, LAMP-based assay, NGS-based assay, or lateral flow assay. We, however, focus our discussion on the three lateral flow-based assays relative to others, highlighting the advantages they present above the other techniques and their potential applicability as a POC diagnostic test for M. bovis infections. We therefore call for further research on developing a lateral flow-based screening tool that could revolutionize the diagnosis of M. bovis infection.
Welfare Becomes Punishment: Penal Nationalism in Danish Social Policy
Authors: Bjerre Cecilie , Brinkgaard Lea Cecilie 
Published: May 2024

Abstract
In this article, we demonstrate how ‘penal nationalism’ came to influence Danish social policy during the 2000s. While critical evaluations of the Nordic Exceptionalism thesis have underscored the significance of immigration in shaping both penal and border policies of the Nordic welfare states, our analysis delves into the core of the Danish welfare state by examining the implementation of the social policy tool, Parenting and Youth Orders. Through this case study, we show how penal instruments were integrated into social policy to regulate citizens with immigrant backgrounds residing in Denmark. These political innovations encompass the reinforcement and legitimization of (1) the explicit targeting of citizens with ethnic minority background and (2) the utilization of new penal instruments within the social realm.
160 RETROPERITONEAL PARAGANGLIOMA: A SINGLE INSTITUTION SERIES OF 111 OPERATIONS
Authors: Knyazeva P , Buzanakov D , Walz M K 
Published: May 2024

Abstract

Background
Due to the extended variety in localization, the choice of surgical strategy in the treatment of retroperitoneal paragangliomas can be challenging. In this study, we collected and analyzed our experience on a large series of patients.

Methods
A total of 111 retroperitoneal paraganglioma operations were performed on 100 patients between January 2000 and December 2023 at our institution. There were 42 female and 58 male patients with a mean age of 39 ± 18. The genetic mutation was known in 62 cases at the time of surgery (VHL - 37, SDH gene mutations - 24, MEN 2B -1). The consecutive data were prospectively collected and retrospectively analyzed.

Results
Out of 111 paraganglioma surgeries, 32 were performed laparoscopically (median operating time: 102 min; range: 37-630), 65 retroperitoneoscopically (69 min; range: 18-510), seven combined laparo-retroperitoneoscopically (340 min; range: 60-630), and seven open (340 min; range: 245-745). The median tumor size for minimally invasive operations was 2.5 cm (range 0.5-9), while for open operations or those with conversion, it was 7 cm (range 2-15). Three conversions to open surgery occurred. Five patients had distant metastasis (four with SDHB and one with VHL mutation). Ten patients underwent more than one operation. Complications included isolated cases of postoperative hematoma, relaxation, and dysesthesia of the flank. Blood transfusions were needed in two cases. The median hospital stay was 4 days (2-30).

Conclusions
Minimally invasive surgery is the gold standard for paragangliomas; nevertheless, the operation can be challenging and requires extensive experience in laparoscopic surgery.
143 A PROLONGED VAGAL LATENCY AT THE BEGINNING OF THYROID RESECTIONS PREDICTS AN INCREASED RISK FOR TEMPORARY AND PERMANENT RECURRENT LARYNGEAL NERVE PARESIS
Authors: Wild F , Staubitz-Vernazza J I , Lederer A K , Musholt P B , Musholt T J 
Published: May 2024

Abstract

Background
We hypothesized that - using intraoperative neuromonitoring (IONM) - a “prolonged” vagal latency at the beginning of (hemi)thyroidectomy is associated with an increased risk of recurrent laryngeal nerve (RLN) dysfunction when the patient’s body height is taken into account.

Methods
A single center retrospective data analysis of 1188 datasets for left and 1203 datasets for right thyroid procedures in 1490 patients was carried out. IONM data was merged with the respective clinical datasets recorded in the EUROCRINE® registry. Onset latency of the vagus nerve at the beginning of a procedure (V1) was analyzed for a correlation with postoperative RLN paresis. The patient’s height and other factors with potential impact on the vagal latency were analyzed to determine the threshold of a “prolonged” latency as indicator of nerve pre-damage.

Results
A positive correlation between patient body height and the V1 latency was identified. A significant difference of the V1 latency for patients with recorded RLN damage in comparison to patients without nerve damage was discovered (left: p=0.0003951, right: p=0.018). A prolonged left V1 latency is about 2.9 ms longer than the height-adjusted “normal” latency (regression analysis) and is associated with a higher risk of RLN paresis.

Conclusions
For the first time, it was proven that IONM latency is one of the indicators of an increased risk of RLN paresis in thyroid surgery. A table of “prolonged” left/right vagal latencies in correlation to patient body height is provided, alerting the surgeon to use extra caution or to change the operative strategy.
267 PROPHYLACTIC CENTRAL COMPARTMENT LYMPH NODE DISSECTION IN CN0 PAPILLARY THYROID CANCER: NO IMPACT ON SURGICAL AND ONCOLOGICAL OUTCOMES AFTER 10 YEARS OF FOLLOW-UP – FINDINGS FROM A PROSPECTIVE RANDOMIZED CONTROLLED SINGLE INSTITUTION STUDY
Authors: Papini P , Rossi L , De Renzis A , Sacco L , Becucci C , Ambrosini C E , Matrone A , Elisei R , Materazzi G 
Published: May 2024

Abstract

Background
Papillary thyroid cancer (PTC) is the dominant histotype in thyroid tumors, with reported central compartment metastases in 65% of cases. Prophylactic central compartment dissection(pCCND) in cN0 patients is debated. This prospective randomized study aims to assess the clinical, surgical, and oncological benefits and drawbacks of pCCND over ten years of follow-up.

Methods
Between 2008 and 2010, 181 cN0 PTC patients were randomly assigned to two groups. Group A underwent total thyroidectomy(TT), and Group B underwent TT+pCCND. Post-surgery, following European guidelines, patients received low-dose radioiodine treatment(30 mCi), with additional doses(100-150 mCi) as needed. Monitoring, including serum Thyroglobulin(Tg), Tg Antibodies(AbTg), and neck ultrasounds, occurred every 12–18 months.

Results
At the end of the follow-up, 31 patients were lost, leaving 150 in the study (Group A: 70, Group B: 80). Both groups were comparable in age(p=0.641), BMI(p=0.113), nodule diameter(p=0.148), and tumor characteristics. After more than 10 years(mean follow-up: 12.9±2 years), no significant differences were observed in surgical and oncological outcomes. Mean Tg levels were 0.11±0.05 ng/ml(Group A) and 0.33±1.26 ng/ml (Group B)(p=0.146). Only one Group B patient had serum Tg antibody levels exceeding 15 IU/ml, with no variations. No significant differences in complication rates (permanent hypoparathyroidism, p=0.229; permanent vocal cord paralysis, p=0.640) and recurrence(p=0.640) were noted. Neither radioiodine dose(p=0.820) differed. The only observed distinction was more parathyroid removal in pCCND cases based on histological examination(p=0.005).

Conclusions
Patients with PTC without preoperative or intraoperative evidence of suspicious lymph nodes (cN0), whether treated with TT alone or TT+pCCND, exhibited similar outcomes in terms of recurrence, disease persistence, and complications.
87 THE ROLE OF LUGOL SOLUTION BEFORE TOTAL THYROIDECTOMY FOR BASEDOW DISEASE: A RANDOMIZED CLINICAL TRIAL
Authors: Schiavone D , Torresan F , Dughiero S , Lizarazo J L C , Crimì F , Pennelli G M , Sacchi D , Censi S , Mian C , Iacobone M 
Published: May 2024

Abstract

Background
Lugol solution (LS) is often administrated preoperatively in patient with Basedow disease (BD), aiming to reduce thyroid vascularization and surgical morbidity, but its real effectiveness remains controversial. This study was aimed to evaluate the effects of preoperative LS on thyroid vascularization and surgical morbidity in patients with BD.

Methods
Fifty-six patients undergoing total thyroidectomy for BD by a single experienced surgeon were enrolled in a prospective, monocentric, single-blinded cohort trial and randomly assigned to receive preoperative (7 days) LS treatment (LS+ Group, n=29) or no LS treatment (LS- Group, n=27). Preoperative hormonal, color-doppler ultrasonographic data (assessing thyroid vascularization), were assessed 7 days before surgery (T0) and the day of surgery (T1). Intra and post-operative blood loss, length of surgery, and morbidity were assessed. Histopathological findings (micro-vessel density at immunohistochemistry) were also assessed at final pathology.

Results
No differences in demographics, preoperative hormonal and ultrasonographic data were found between LS+ and LS- at T0. FT3 and FT4 were significantly reduced at T1 compared to T0 in LS+ (p=0.02) while no significant variations occurred in LS-. No differences between T0-T1 were found for ultrasonographic vascularization data in both groups. Histopathological finding did not differ between LS+ and LS-. No significant differences were found between LS+ and LS- concerning intra/postoperative blood loss (80.5 vs 94ml, respectively), length of surgery (75’ in both groups), and postoperative morbidity.

Conclusions
LS significantly reduces FT3, FT4 in patient undergoing surgery for BD but doesn’t decrease intra/postoperative blood loss, thyroid vascularization, length of surgery and morbidity.
165 PREDICTIVE MODEL OF THYROID SURGERY SUFFICIENCY IN PATIENTS WITH BETHESDA III AND IV: “THE RULE OF FOUR”
Authors: Guirao X , Barcons S , Pérez-Riverola V , Bella B , Molero-Cano C , Landa T , Albert Fàbregas L , Rigla M 
Published: May 2024

Abstract

Background
Thyroid lobectomy (TL) in patients with thyroid nodule (TN) Bethesda III (BIII) and IV (BIV) purports a totalization when pathology informs of high-risk malignancy (HRM: Cell high risk phenotype and/or widely invasive-angioinvasive thyroid carcinoma). Studies on predictive variables correlating with HRM are lacking.

Methods
Data on demographics, TIRADS, Bethesda, size of TN, extension of thyroidectomy of patients operated on for BIII and BIV TN have been retrieved from a prospective database and compared between low risk (LR: Benign, low risk neoplasm and malignancy, minimally invasive/non angioinvasive) and HRM groups. A predictive model has been constructed and sensitivity (SE), specificity (SP), positive (PPV) and negative predictive value (NPV) and area under curve (AUC), have been calculated. Quantitative data are summarized as a mean ± SD and analysis of qualitative variables have done with X2 test.

Results
One-hundred eight patients with a mean age of 53±25 years, 70.4% females and 70.4 and 29.6% of BIII and BIV were assessed. TL and TT were performed in 62 and 38%. Thyroid malignancy was reported in 28.9 and 56.3% in BIII and BIV. TN &gt;4 cm and TIRADS 4-5 correlated with final HRM pathology (p=0.004 and p=0.003). Elicited significant variables predicted model construct showed a SE, SP, PPV, NPV and AUC of 0.45, 0.94, 0.72, 0.82 and 0.77, respectively.

Conclusions
The predictive model construct to detect patients at risk for HRM thyroid nodules, may be useful in the shared decision of the extension of thyroid surgery.
71 DOES VIRTUAL REALITY IMPROVE PREOPERATIVE PATIENT INFORMATION IN PRIMARY HYPERPARATHYROIDISM?
Authors: Chorti A , Moysidis M , Vouchara A , Poulios E , Bakkar S , Ioannis P , Theodossis P 
Published: May 2024

Abstract

Background
Parathyroid adenoma is the most common cause of primary hyperparathyroidism. It is characterized by hypersecretion of parathormone and elevated serum concentration of ionized calcium. Patient preoperative information is of great importance and should include the explanation of hyperparathyroidism pathophysiology and clinical characteristics, the surgical procedure and its complications and effectiveness. The aim of the present study is to evaluate the effectiveness of virtual reality application in preoperative information of patients with parathyroid adenoma.

Methods
Patients with parathyroid adenoma who undergone surgery in our Surgical Department from 2016-2022 were enrolled in this study. They were divided in two groups: Group A underwent the standard preoperative information, whereas in Group B, a virtual reality video of parathyroidectomy was added to the standard preoperative information. Postoperatively, patients’ satisfaction was evaluated, applying a patients’ satisfaction questionnaire.

Results
Group A included 118 patients (2016-2018), while group B included 148 patients (2019-2022). Patients’ satisfaction questionnaire consisted of 10 questions, from which two had statistically significant difference between groups, referring to the effectiveness of virtual reality video parathyroidectomy in the understanding of the disease and surgical procedure. Group A patient’s percentage with score very good/excellent was 82%, while in group B the percentage was 93% (p&lt;0.05).

Conclusions
Patient comprehension of primary hyperparathyroidism, surgical management and possible complications are of great importance preoperatively. Virtual reality application has been proved beneficial in preoperative patient information.
214 US PATTERS AS A PROGNOSTIC FACTOR IN THYROID PAPILLARY MICROCARCINOMA: IS mETE STILL USEFUL FOR DECISION MAKING FOR FNAC AND SURGICAL STRATEGY?
Authors: Cossa A , Monti S , Bartolazzi A , Nigri G , Sbacco V , Bellotti C 
Published: May 2024

Abstract

Background
The 2015 ATA guidelines recommend FNAC only for nodules &gt; 1 cm, but report studies justifying FNAC also for nodules &lt; 1 cm but with suspicious ultrasound features. The 8th edition of the AJCC TNM eliminated capsular infiltration (CI) as a negative prognostic factor. These features leave wide margins of discretion in T1a and T1b patients.

Methods
According to guidelines, we treated T1a and T1b patients with ultrasound signs of suspicion for extrathyroidal extension (mETE), with a total or unilateral thyroidectomy, ipsilateral central-compartment neck dissection, and extemporaneous histological verification for possible extended surgery (completing lymphectomy and thyroidectomy). We enrolled 132 patients with the following characteristics: US positive for contact of nodule with the capsule and suspect of ETE according with TIRADS classification. Patients were divided into 3 groups according to the probability of having mETE according to the ultrasound examination.

Results
We calculated the correlation between the presence of mETE and N1a+, specificity and Sensitivity of US in predicting CI in the two groups. In pT1a patients 68% had CI and 55% of these were N1a+. In pT1b patients 61% had CI and 52% of these were N1a+. The sensitivity of the US was 77% and the specificity 55%.

Conclusions
Our results demonstrate a correlation between CI and metastasis in the central compartment in both T1a and T1b patients. Furthermore, ultrasound appears to be very sensitive and low specific in predicting CI. These data question the current trend of a decreased focus on microcarcinomas on the basis of a size cut-off alone.
A New Concept for Reference Change Values—Regression to the Population Mean
Authors: Jones Graham R D , Aarsand Aasne K , Carobene Anna , Coskun Abdurrahman , Fernandez-Calle Pilar , Bartlett Bill , Diaz-Garzon Jorge , Sandberg Sverre 
Published: May 2024

Abstract

Background
Reference change values (RCV) are used to indicate a change in analyte concentration that is unlikely to be due to random variation in the patient or the measurement. Current theory describes RCV relative to a first measurement result (X1). We investigate an alternative view predicting the starting point for RCV calculations from X1 and its location in the reference interval.

Methods
Data for serum sodium, calcium, and total protein from the European Biological Variation study and from routine clinical collections were analyzed for the effect of the position of X1 within the reference interval on the following result from the same patient. A model to describe the effect was determined, and an equation to predict the RCV for a sample in a population was developed.

Results
For all data sets, the midpoints of the RCVs were dependent on the position of X1 in the population. Values for X1 below the population mean were more likely to be followed by a higher result, and X1 results above the mean were more likely to be followed by lower results. A model using population mean, reference interval dispersion, and result diagnostic variation provided a good fit with the data sets, and the derived equation predicted the changes seen.

Conclusions
We have demonstrated that the position of X1 within the reference interval creates an asymmetrical RCV. This can be described as a regression to the population mean. Adding this concept to the theory of RCVs will be an important consideration in many cases.
Intermittent Fault Diagnosis Of Product Network Based On PMC Model
Authors: Feng Hao , Wu Jiong , Chen Lin 
Published: May 2024

Abstract
Fault diagnosis of processors plays a critical role in assessing the reliability of multiprocessor systems. The interconnection network’s diagnosability is an important metric for measuring its self-diagnostic capability which has been extensively studied in many novel mutiprocessor systems. Permanent fault diagnosability for many mutiprocessor systems has been determined; however intermittent fault diagnosability is hard to obtain due to its crypticity. In this paper, we focus on the problem pertaining to the diagnosability in the intermittent fault situation. First, by learning the characteristics of intermittent fault diagnosis in PMC model, we propose some theorems and lemmas for intermittent fault diagnosability. Secondly, we give the range of intermittent fault diagnosability of product network. Lastly, by adopting the theorems, we propose an Auto-IFD algorithm to find the intermittent faults of the hypercube network and conduct experiments to verify the theorems.
Collecting and managing in situ banana genetic resources information (Musa spp.) using online resources and citizen science
Authors: Jenny Christophe , Guignon Valentin , Manyer I Ballester Felip , Ruas Max , Rouard Mathieu 
Published: May 2024

Abstract
The Musa Germplasm Information System (MGIS) stands as a pivotal database for managing global banana genetic resources information. In our latest effort, we have expanded MGIS to incorporate in situ observations. We thus incorporated more than 3000 in situ observations from 133 countries primarily sourced from iNaturalist, GBIF, Flickr, Pl@ntNet, Google Street view and expert curation of the literature. This addition provides a more comprehensive and detailed view of banana diversity and its distribution. Additional graphical interfaces, supported by new Drupal modules, were developed, allowing users to compare banana accessions and explore them based on various filters including taxonomy and geographic location. The integrated maps present a unified view, showcasing both in situ observations and the collecting locations of accessions held in germplasm collections. This enhancement not only broadens the scope of MGIS but also promotes a collaborative and open approach in documenting banana diversity, to allow more effective conservation and use of banana germplasm. Furthermore, this work documents a citizen-science approach that could be relevant for other communities.
Database URL: https://www.crop-diversity.org/mgis/musa-in-situ
Vertical distribution and tissue selection of Helicoverpa zea (Lepidoptera: Noctuidae) adult oviposition and neonates on soybean with an indeterminate or determinate growth habit
Authors: Possebom Taynara , Reisig Dominic , Huseth Anders , Vann Rachel 
Published: May 2024

Abstract
Helicoverpa zea (Boddie) is a polyphagous pest that can cause serious damage to crops, including soybeans (Glycine max L.). In soybeans with both determinate and indeterminate growth habits, H. zea larvae are more commonly found on leaves compared to blooms, stems, and pods. Past research demonstrated that H. zea adults tend to oviposit near the upper part of the plant canopy in soybeans with a determinate growth habit. However, ovipositional selection on soybeans with an indeterminate growth habit is unknown. We hypothesized that H. zea would oviposit more uniformly throughout the canopy on indeterminate soybean growth habits due to more diffuse reproductive tissue. We planted field and greenhouse experiments with varieties sharing a similar relative maturity (2 maturity group [MG] 5.2 varieties and 2 MG 5.4/5.5 varieties) but with different growth habits. To test oviposition selection, adult H. zea females were allowed to oviposit under field and caged conditions. We counted the number of H. zea eggs and neonates on each plant tissue type from each of 3 equal parts in the plant canopy: upper, middle, and lower. In both experiments, eggs and neonates were most common on leaves at the top of the plant regardless of soybean growth habit. Consequently, ovipositional selection is likely independent of reproductive tissue availability, and patterns of oviposition through the canopy are similar in growth habits. An improved understanding of H. zea ecology in soybeans relative to indeterminate growth habits may improve recommendations for managing this significant pest of soybean.