bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congenital heart defect case ascertainment by the Alberta Congenital Anomalies Surveillance System
Authors: Bedard Tanya , Lowry R. Brian , Sibbald Barbara , Harder Joyce R. , Trevenen Cynthia , Horobec Vera , Dyck John D. 
Published: April 2012

AbstractBACKGROUNDCongenital heart defects (CHDs) are the most common type of congenital anomaly, with a wide range of reported birth prevalence estimates. This quality assurance study describes CHD case ascertainment by the Alberta Congenital Anomalies Surveillance System (ACASS).METHODSACASS data for CHD cases were compared with additional sources including the two Pediatric Cardiology clinics in Alberta, the Alberta Children's Hospital Department of Pathology, and hospital records. Cases included live births, stillbirths, and fetal deaths at less than 20 weeks' gestation born in Alberta, Canada, between 1995 and 2002. The birth prevalence of cases and chi‐square linear trend analyses were calculated for specific types of heart defects for the total study period.RESULTSThe ascertainment of CHD cases by ACASS was 45%. The total prevalence of CHD cases was 5.59 per 1000 total births (TBs; 95% confidence interval [CI], 5.32–5.86) when ACASS was the only data source and increased to 12.42 per 1000 TBs (95% CI, 12.03–12.83) when all data sources were used. Although the total prevalence of CHD cases remained stable during 1995 to 2002, the prevalence of atrial septal defect (ASD) and cases with an ASD and ventricular septal defect (VSD) significantly increased. The prevalence of left ventricular outflow tract obstruction cases significantly decreased during the study period.CONCLUSIONSPediatric cardiology clinics are worth including as additional ascertainment sources to contribute to more accurate prevalence estimates. The significant increases of ASD and cases with both an ASD and VSD may reflect differences in diagnostic and ascertainment practices. Birth Defects Research (Part A) 2012. © 2012 Wiley Periodicals, Inc.
Hybridanker aus UHPC – Erstanwendung bei der Verstärkung der Rheinschleuse Iffezheim mit Dauerlitzenankern
Authors: Weiher Hermann , Tritschler Christian , Glassl Michael , Hock Sebastian 
Published: April 2012

AbstractHybridankerplatten stellen eine vorgefertigte Verankerungslösung für Zugglieder (Spannglieder, Verpressanker) dar, bei der die Werkstoffe ultrahochfester Beton (UHPC) und Stahl oder Kohlefaser entsprechend ihrer Eigenschaften kombiniert werden. Sie wurden erstmals im Juli 2011 bei der Verstärkung des Hauptdrempels der Rheinschleuse in Iffezheim als aufgesetzte Verankerungsplatten für Dauerlitzenanker eingesetzt. Mit den dauerhaften Hybridankerplatten konnte der Ankerkopf bei beengten Verhältnissen äußerst kompakt auf den unbewehrten Altbeton aufgesetzt werden.First application of composite anchor plates (“Hybridanker”) for strengthening a Rhine lock with permanent ground anchorsPrefabricated composite anchor plates are using high performance concrete and steel or carbon fibres for load transfer of tendon forces (post‐tensioning tendons, ground anchors). First application of the Hybridanker‐type has been realized at the Rhine lock in Iffezheim, where permanent multistrand ground anchors had been installed. The prefabricated Hybridanker‐solution allowed a durable and compact load transfer to old, unreinforced concrete.
Weltstadthaus Peek & Cloppenburg Wien
Authors: Akkermannn Jan , Golonka Krzysztof 
Published: April 2012

AbstractBeim Neubau eines Kaufhauses in der Wiener Innenstadt wurde bereits im Rohbau eine mögliche Teilung des kompletten Gebäudetragwerks in Einzelbauwerke berücksichtigt. Es werden die Teilungsoptionen sowie die hierfür bereits umgesetzten konstruktiven Maßnahmen beschrieben.
Continuous microalgae cultivation in a photobioreactor
Authors: Tang Haiying , Chen Meng , Simon Ng K.Y. , Salley Steven O. 
Published: April 2012

AbstractNew biomass sources for alternative fuels has become a subject of increasing importance as the nation strives to resolve the economic and strategic impacts of limited fossil fuel resources on our national security, environment, and global climate. Algae are among the most promising non‐food‐crop‐based biomass feedstocks. However, there are currently no commercially viable microalgae‐based production systems for biofuel production that have been developed, as limitations include less‐than optimal oil content, growth rates, and cultivation techniques. While batch studies are critical for determining basic growth phases and characteristics of the algal species, steady‐state studies are necessary to better understand and measure the specific growth parameters. This study evaluated the effects of dilution rate on microalgal biomass productivity, lipid content, and fatty acid profile under steady‐state conditions with continuous illumination and carbon dioxide supplemention for two types of algae. Continuous cultures were conducted for more that 3 months. Our results show that the productivity of Chlorella minutissima varied from 39 to 137 mg/L/day (dry mass) when the dilution rate varied from 0.08 to 0.64 day−1. The biomass productivity of C. minutissima reached a maximum value (137 mg/L/day) at a dilution rate of 0.33 day−1, while the productivity of Dunaliella tertiolecta varied from 46 to 91 mg/L/day at a dilution rate of 0.17 to 0.74 day−1. The biomass productivity of D. tertiolecta reached a maximum value of 91 mg/L/day at a dilution rate of 0.42 day−1. Moreover, the lipid content had no significant change with various dilution rates. Biotechnol. Bioeng. 2012; 109: 2468–2474. © 2012 Wiley Periodicals, Inc.
Bestimmung des Reinheitsgrades von Flüssigkeiten mit dem Refraktometer
Authors: Schrödel Andrea 
Published: April 2012

AbstractMit Hilfe eines Refraktometers kann grob der Reinheitsgrad von Flüssigkeiten bestimmt werden. Der hierbei zu bestimmende Brechungsindex ist konzentrationsabhängig. Daher wird diese Methode auch zur Konzentrationsbestimmung von Lösungen und zur Kontrolle von Trennprozessen (z. B. analytischer Destillationen) angewandt. Die Methode ist zwar nicht ganz einfach zu verstehen, dafür ist die Handhabung des Gerätes aber umso einfacher.
Multicentre observational study of the natural history of left-sided acute diverticulitis (Br J Surg 2012; 99: 276–285) (Br J Surg 2012; 99: 285–286)
Authors: Binda G A , Serventi A , Altomare D F 
Published: April 2012

Abstract
The Editors welcome topical correspondence from readers relating to articles published in the Journal. Responses should be sent electronically via the BJS website (http://www.bjs.co.uk). All letters will be reviewed and, if approved, appear on the website. A selection of these will be edited and published in the Journal. Letters must be no more than 250 words in length.
Luminescent Blooming of Dendronic Carbon Nanotubes through Ion‐Pairing Interactions with an EuIII Complex
Authors: Maggini Laura , Toma Francesca Maria , Feruglio Luigi , Malicka Joanna M. , Da Ros Tatiana , Armaroli Nicola , Prato Maurizio , Bonifazi Davide 
Published: April 2012

AbstractA multiwalled carbon nanotube (MWCNT) scaffold was covalently functionalized with a second‐generation polyamidoamine (PAMAM) dendron, presenting four terminal amino groups per grafted aryl moiety. These reactive functions were alkylated to obtain a positively charged polycationic dendron/carbon nanotube system (d‐MWCNTs⋅Cl), which eventually underwent anion exchange reaction with a negatively charged and highly luminescent EuIII complex ([EuL4]⋅NEt4, in which L=(2‐naphtoyltrifluoroacetonate)). This process afforded the target material d‐MWCNTs⋅[EuL4], in which MWCNTs are combined with red‐emitting EuIII centers through electrostatic interactions with the dendronic branches. Characterization of the novel MWCNT materials was accomplished by means of TGA and TEM, whereas d‐MWCNTs⋅Cl and d‐MWCNTs⋅ [EuL4] further underwent XPS, SEM and Raman analyses. These studies demonstrate the integrity of the luminescent [EuL4]− center in the luminescent hybrid, the massive load of the cationic binding sites, and the virtually complete anion‐exchange into the final hybrid material. The occurrence of the ion‐pairing interaction with MWCNTs was unambiguously demonstrated through DOSY NMR diffusion studies. Photophysical investigations show that MWCNTs⋅[EuL4] is a highly soluble and brightly luminescent red hybrid material in which MWCNTs act as photochemically inert scaffolds with negligible UV/Vis absorption, compared with the grafted Eu complex, and with no quenching activity. The high dispersibility of MWCNTs⋅[EuL4] in a polymer matrix makes it a promising luminophore for applications in material science.
Ion‐Pair Recognition by a Heteroditopic Triazole‐Containing Receptor
Authors: Picot Simon C. , Mullaney Benjamin R. , Beer Paul D. 
Published: April 2012

AbstractA new heteroditopic calix[4]diquinone triazole containing receptor capable of recognising both cations and anions through Lewis base and CH hydrogen‐bonding modes, respectively, of the triazole motif has been prepared. This ion‐pair receptor cooperatively binds halide/monovalent‐cation combinations in an aqueous mixture, with selectivity trends being established by 1H NMR and UV/Vis spectroscopy. Cation binding by the calix[4]diquinone oxygen and triazole nitrogen donors enhances the strength of the halide complexation at the isophthalamide recognition site of the receptor. Conversely, anions bound in the receptor’s isophthalamide cavity enhance cation recognition. 1H NMR investigations in solution suggest that the receptor’s triazole motifs are capable of coordinating simultaneously to both cation and anion guest species. Solid‐state X‐ray crystallographic structural analysis of a variety of receptor ion‐pair adducts further demonstrates the dual cation–anion binding role of the triazole group.
Kommentar zu: H. Mustroph, S. Ernst “Das Franck‐Condon‐Prinzip”
Authors: Köhn A. , Diezemann G. , Berger R. , Basché Th. 
Published: April 2012

AbstractDie Zeitschrift “Chemie in unserer Zeit” wendet sich an ein breites Leserspektrum. Sie will zuverlässig über neue Entwicklungen in der Chemie und verwandten Gebieten berichten sowie komplexe Sachverhalte auch für den Nichtfachmann verständlich aufbereiten. Mit großem Bedauern kommen wir jedoch zu der Einschätzung, dass der Beitrag “Wer kennt es noch? Das Franck‐Condon‐Prinzip” von H. Mustroph und S. Ernst (im Folgenden als Ref. 1 bezeichnet) nach unserem Ermessen diesem Anspruch nicht gerecht wird. Der Beitrag enthält einige erhebliche fachliche Fehler sowie sachlich unbegründete und zum Teil irreführende Kritik an Lehrbuchinhalten und wissenschaftlichen Arbeiten. Wir sehen es daher geboten, in einem Kommentar auf einige wesentliche Punkte hinzuweisen. Für den interessierten Leser stellen wir in einer Langversion dieses Kommentars (zugänglich in der Online‐Version der Zeitschrift) eine kurze weitergehende Darstellung des Themas zur Verfügung.
Das Franck‐Condon‐Prinzip – eine Antwort der Autoren
Authors: Mustroph Heinz , Ernst Steffen 
Published: April 2012

AbstractAuf unseren Beitrag zum Franck‐Condon‐Prinzip erhielten wir überraschend viele Reaktionen. Da das Franck‐Condon‐Prinzip unserer Meinung nach in den meisten Lehrbüchern falsch dargestellt ist, verwundert es nicht, dass es neben vielen zustimmenden und dankbaren auch kritische Bemerkungen gibt. Es ist sehr anerkennenswert, dass sich unsere Kritiker der öffentlichen Diskussion stellen. Wir gehen davon aus, dass die von ihnen vertretenen Ansichten weit verbreitet sind und hoffen, dass die Leser durch den Disput angeregt werden, sich mit beiden unterschiedlichen Positionen aktiv auseinanderzusetzen. Dazu stellen auch wir eine ausführliche Erwiderung auf der Webseite dieser Zeitschrift zur Verfügung und würden uns über weitere Kommentare freuen.
Ackerböden im Stickstoffkreislauf
Authors: Feil Sylvia 
Published: April 2012

AbstractStickstoff‐fixierende Bakterien, die symbiontisch mit Leguminosen leben, sind weitläufig bekannt. Ihr Pendant, die Stickstoff‐freisetzenden Bakterien, rücken bei den steigenden Emissionen des Treibhausgases Lachgas ins Blickfeld.
“Warum wird mein Apfel braun?”
Authors: Hein Susanne 
Published: April 2012

AbstractDas “Haus der kleinen Forscher” ist Deutschlands größte Initiative zur frühkindlichen Bildung. Mädchen und Jungen sollen bereits ab dem Kindergartenalter ihr Interesse für Naturwissenschaften, Technik und Mathematik entdecken können. Bundesweit erreicht das Bildungsangebot bereits über 20.000 Kindertagesstätten und Grundschulhorte; bis 2015 will die gemeinnützige Stiftung “Haus der kleinen Forscher” ihr Netzwerk soweit ausgebaut haben, dass jede Kita in Deutschland von dem Angebot profitieren kann.
Wissenschaft und Kunst der Materie
Authors: Mahler Stefanie 
Published: April 2012

Abstract“Die großen Herausforderungen, die wir vor uns haben, betreffen die Energiefrage, die Umwelt und das Klima – dabei sind stets chemische Prozesse im Spiel, die wir besser verstehen müssen.” Das Zitat des Nobelpreisträgers Gerhard Ertl könnte als Motto der Ausstellung “Bildende Kunst: Chemie im 21. Jahrhundert” gelten. Denn die Themen ebenso wie das Design der Max Planck Science Gallery sind zukunftsgerichtet. Alles dreht sich um Chemie – und welche chemische Grundlagenforschung in mehr als 20 Max‐Planck‐Instituten heute betrieben wird.
Hydroxamic Acids as Potent Inhibitors of FeII and MnIIE. coli Methionine Aminopeptidase: Biological Activities and X‐ray Structures of Oxazole Hydroxamate–EcMetAP‐Mn Complexes
Authors: Huguet Florian , Melet Armelle , Alves de Sousa Rodolphe , Lieutaud Aurélie , Chevalier Jacqueline , Maigre Laure , Deschamps Patrick , Tomas Alain , Leulliot Nicolas , Pages Jean‐Marie , Artaud Isabelle 
Published: April 2012

AbstractNew series of acids and hydroxamic acids linked to five‐membered heterocycles including furan, oxazole, 1,2,4‐ or 1,3,4‐oxadiazole, and imidazole were synthesized and tested as inhibitors against the FeII, CoII, and MnII forms of E. coli methionine aminopeptidase (MetAP) and as antibacterial agents against wild‐type and acrAB E. coli strains. 2‐Aryloxazol‐4‐ylcarboxylic acids appeared as potent and selective inhibitors of the CoII MetAP form, with IC50 values in the micromolar range, whereas 5‐aryloxazol‐2‐ylcarboxylic acid regioisomers and 5‐aryl‐1,2,4‐oxadiazol‐3‐ylcarboxylic acids were shown to be inefficient against all forms of EcMetAP. Regardless of the heterocycle, all the hydroxamic acids are highly potent inhibitors and are selective for the MnII and FeII forms, with IC50 values between 1 and 2 μM. One indole hydroxamic acid that we previously reported as a potent inhibitor of E. coli peptide deformylase also demonstrated efficiency against EcMetAP. To gain insight into the positioning of the oxazole heterocycle with reversed substitutions at positions 2 and 5, X‐ray crystal structures of EcMetAP‐Mn complexed with two such oxazole hydroxamic acids were solved. Irrespective of the [metal]/[apo‐MetAP] ratio, the active site consistently contains a dinuclear manganese center, with the hydroxamate as bridging ligand. Asp 97, which adopts a bidentate binding mode to the Mn2 site in the holoenzyme, is twisted in both structures toward the hydroxamate bridging ligand to favor the formation of a strong hydrogen bond. Most of the compounds show weak antibacterial activity against a wild‐type E. coli strain. However, increased antibacterial activity was observed mainly for compounds with a 2‐substituted phenyl group in the presence of the nonapeptide polymyxin B and phenylalanine–arginine–β‐naphthylamide as permeabilizer and efflux pump blocker, respectively, which boost the intracellular uptake of the inhibitors.
Psychiatric Comorbidity is Associated with Increased Skill Deficits
Authors: Stenzel Nikola , Krumm Stefan , Hartwich‐Tersek Jens , Beisel Sylvia , Rief Winfried 
Published: April 2012

Recent research on psychotherapy has focused on the development and evaluation of disorder‐specific treatments. Even though much progress has been made, treatments have not yet reached an ideal level of effectiveness. One reason for this could be the systematic overlap and high comorbidity between mental disorders. Consequently, a new trend has been the examination of transdiagnostic factors in order to conceptualize psychopathology and develop treatment tools. One approach is to strengthen skills (e.g., emotion regulation) that are relevant in different mental disorders. The unique feature of this study is the simultaneous examination of several skills and their relation to psychopathology. Therefore, the current study investigated the skill levels of different groups of inpatients (tinnitus, tinnitus/unipolar mood disorder and anxiety/unipolar mood disorder) and normal controls (n = 124). Participants were evaluated with the ‘operationalized assessment of skills interview’. This interview allows the simultaneous assessment of seven skills (problem solving, social competence, stress management, emotion regulation, relaxation ability, self‐efficacy and self‐esteem) that are relevant for treatment planning. The results confirm negative correlations between skills and the number of comorbid diagnoses. Multivariate analyses identified significant differences in skill levels between clinical sample and normal controls. Furthermore, within the clinical sample, there were significant differences in skill levels and skill profiles between the different clinical subsamples. To conclude, the improvement of skills that can support recovery from mental disorders is especially relevant for patients with multiple diagnoses. The authors suggest assessing the different skills prior to treatment and considering the skill profiles when planning interventions. Copyright © 2012 John Wiley & Sons, Ltd.Key Practitioner Message

Lower skill levels are associated with higher comorbidity and higher level of psychopathology of patients.
There is evidence for specific skill profiles within different clinical subsamples.
The improvement of skills that can impact recovery from mental disorders is especially relevant for patients with multiple diagnoses.
It makes sense to assess the different skills independently and consider them separately when planning interventions.
Praktische Umsetzung von DIN EN 1996/NA – D in Bemessungssoftware
Authors: Hoffmann Jens 
Published: April 2012

AbstractDurch den softwaregestützten Nachweis von Mauerwerk ist die Einführung einer neuen Bemessungsnorm für den Endanwender auch ohne detaillierte Kenntnis der Norm möglich. Dennoch müssen für die korrekte Anwendung der neuen Norm teils zusätzliche Vorgaben gemacht werden, die einer Erläuterung bedürfen, und es sollten die Auswirkungen neuer Regelungen und Inhalte bekannt sein. Der vorliegende Artikel soll anhand der Erfahrungen, die bei der Umsetzung von DIN EN 1996 für unbewehrtes Mauerwerk in den Mauerwerksprogrammen der Firma Friedrich Lochner GmbH gemacht wurden, einige Hintergründe zu diesen Änderungen beleuchten und somit einen Beitrag zur möglichst reibungslosen Einführung des Eurocodes für den Mauerwerksbau in Deutschland leisten.Implementation of DIN EN 1996/NA – D in design software. Due to the software‐based design of masonry walls switching to new design standards is not compulsorily associated with the acquisition of a complete knowledge of the new standards. However, the correct application of the new design standards in design software often demands the specification of previously uncommon input parameters and the effects on the results of the design checks and demands should be understood. This paper aims to provide findings and conclusions made during the process of implementation of DIN EN 1996 by the Friedrich Lochner company in their design software for unreinforced masonry, and thus to support the unobstructed introduction of the Eurocodes for masonry in Germany.
Zum methodischen Vorgehen bei der weiteren Entwicklung und Vereinfachung des EC 6 mit seinen Nationalen Anhängen
Authors: Jäger Wolfram 
Published: April 2012

AbstractDas Jahr 2012 markiert eine wichtige Station in der Geschichte der Eurocodes für Deutschland: Für den 01. 07. 2012 ist die bauaufsichtliche Einführung des ersten Paketes der Eurocodes zusammen mit den entsprechenden Nationalen Anhängen und somit der Beginn der praktischen Anwendung der Eurocodes geplant. Die weiteren, nicht in diesem ersten Paket enthaltenen Eurocodes – wozu auch der Mauerwerksbau gehört – werden wenig später folgen. Bereits vor der offiziellen Einführung gibt es den allgemeinen Ruf nach Vereinfachung sowie Einkürzung der neuen Normen. Obwohl andere Eurocodes zum Teil viel umfangreicher und komplizierter sind, steht auch vor dem EC 6 die Frage der Überprüfung und Weiterentwicklung; schließlich hat er den Stand von ca. 2002. Die Überarbeitung soll 2013 beginnen und wird erfahrungsgemäß einen gewissen Zeitraum in Anspruch nehmen. Es ergibt sich dabei die Chance, neue Erkenntnisse – wie sie etwa von deutscher Seite in den Nationalen Anhang aufgenommen worden sind – einzubringen und das Gesamtpaket einschließlich national festzulegender Parameter und zusätzlicher Ergänzungen zu reduzieren.Im Beitrag werden Aufgabenkategorien, die im Mauerwerksbau für die Phase der Überarbeitung anstehen, beleuchtet sowie methodische Lösungs‐ und Bearbeitungswege aufgezeigt.Methodology for the further development and simplification of the EC 6 with its National Annex. The year 2012 is an important point for Germany in the history of Eurocodes. On July 1 2012 the building authority plans the introduction of the most important Eurocodes together with the German annex as mandatory design standards for construction. The remaining Eurocodes – among them the masonry code EC 6 – will follow as soon as possible. Already before the officially introduction the general call for simplification and reduction of extend of the current codes exists. Other Eurocodes than EC 6 are more complex and have a bigger extend. But also the EC 6 will be confronted with the revision and further development, because it has mostly the stage of the year 2002. The start of the revision is foreseen for the year 2013 and will last a specified time according to previous experience. With this revision exists the chance to introduce latest findings like in the German annex as well as to reduce the National Determined Parameters and the additional information.Task categories for the revision will be shown in the paper as well as ways for solutions and working steps.
The influences of perinatal challenge persist into the adolescent period in socially housed bonnet macaques (Macaca radiata)
Authors: Laudenslager Mark L. , Natvig Crystal , Corcoran Christopher A. , Blevins Maria W. , Pierre Peter J. , Bennett Allyson J. 
Published: April 2012

AbstractSocial challenges during the perinatal period influence the mother–infant relationship in nonhuman primates and may affect the offspring's response to later social challenge(s). Relocation of a breeding colony of monkeys (Macaca radiata) created two groups of infants: one group experienced social group relocation to a new housing facility during the perinatal period (ATYPICAL) and the second group developed within a constant environment (TYPICAL). At a mean age of 25 months, all animals were removed from their natal group and placed in same sex adolescent social groups. Behavioral observations were collected after group formation or introduction to a new group. ATYPICAL subjects showed increased aggression and reduced affiliation compared to TYPICAL subjects. Hair cortisol in male subjects collected 6 months after introduction was elevated in the ATYPICAL subjects compared to TYPICAL subjects. These findings demonstrate that early life challenges affect behavior as well as stress hormone responses to social challenge in adolescence. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 55: 316–322, 2013