bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for early death in children with haemophagocytic lymphohistiocytosis
Authors: Trottestam Helena , Berglöf Elisabet , Horne AnnaCarin , Onelöv Erik , Beutel Karin , Lehmberg Kai , Sieni Elena , Silfverberg Thomas , Aricò Maurizio , Janka Gritta , Henter Jan‐Inge 
Published: October 2011

AbstractAim:  Haemophagocytic lymphohistiocytosis (HLH) is a life‐threatening disturbance of immunoregulation. HLH comprises primary and acquired forms with different disease severity. A large proportion of deaths occur early into treatment. We investigated association with early death for laboratory and clinical parameters before the start of and 2 weeks into therapy.Methods:  A total of 232 children from Scandinavia, Germany or Italy, fulfilling diagnostic criteria and/or with familial disease and/or HLH‐causing mutations, receiving HLH treatment 1994–2008 were included. The relation between clinical findings and early pre‐transplant death was examined using the Cox proportional hazards model, with a 4‐month right‐truncation of the outcome. Patients were censored at last follow‐up or transplant. Statistically significant predictors were adjusted for sex, age and each other.Results:  The following features were significantly associated with adverse outcome: hyperbilirubinaemia (>50 μmol/L; adjusted hazard ratio (aHR) 3.2; 95% confidence interval 1.3–8.1, p = 0.011), hyperferritinaemia (>2000 μg/L; aHR 3.2; 1.2–8.6, p = 0.019), cerebrospinal fluid pleocytosis (>100 × 106/L; aHR 5.1; 1.4–18.5, p = 0.012) at diagnosis, and thrombocytopenia (<40 × 109/L; aHR 3.4; 1.1–10.7, p = 0.033), and hyperferritinaemia (>2000 μg/L; aHR 10.6; 1.2–96.4, p = 0.037) 2 weeks into therapy. Non‐improvement of fever, anaemia and/or thrombocytopenia also had adverse impact.Conclusion:  There seem to be easily available clinical predictors of early mortality in HLH patients, which may help guide treatment decisions.
What difference can fathers make? Early paternal absence compromises Peruvian children's growth
Authors: Dearden Kirk , Crookston Benjamin , Madanat Hala , West Joshua , Penny Mary , Cueto Santiago 
Published: October 2011

AbstractConsiderable evidence suggests that fathers' absence from home has a negative short‐ and long‐term impact on children's health, psychosocial development, cognition and educational experience. We assessed the impact of father presence during infancy and childhood on children's height‐for‐age z‐score (HAZ) at 5 years old. We conducted secondary data analysis from a 15‐year cohort study (Young Lives) focusing on one of four Young Lives countries (Peru, n = 1821). When compared with children who saw their fathers on a daily or weekly basis during infancy and childhood, children who did not see their fathers regularly at either period had significantly lower HAZ scores (−0.23, P = 0.0094) after adjusting for maternal age, wealth and other contextual factors. Results also suggest that children who saw their fathers during childhood (but not infancy) had better HAZ scores than children who saw their fathers in infancy and childhood (0.23 z‐score, P = 0.0388). Findings from analyses of resilient children (those who did not see their fathers at either round but whose HAZ > −2) show that a child's chances of not being stunted in spite of paternal absence at 1 and 5 years old were considerably greater if he or she lived in an urban area [odds ratio (OR) = 9.3], was from the wealthiest quintile (OR = 8.7) and lived in a food secure environment (OR = 3.8). Interventions designed to reduce malnutrition must be based on a fuller understanding of how paternal absence puts children at risk of growth failure.
Evaluation of newly developed devices for denture placement and removal in the dependent elderly
Authors: Kawasaki Maiko , Nomura Shuichi , Okada Naoto , Nomura Akiko , Uoshima Katsumi 
Published: October 2011

doi: 10.1111/j.1741‐2358.2011.00547.xEvaluation of newly developed devices for denture placement and removal in the dependent elderlyObjective:  The purpose of this study was to subjectively evaluate the utility of newly developed denture placement and removal devices. Objective observations were also made to support the evidence.Materials and method:  Twenty‐one subjects were instructed to place and remove their dentures with and without the devices. We evaluated the device based on a questionnaire. Objective observations were based on a 2‐D image analysis. We analysed three factors: the time, the area and the circumference required to insert and remove the dentures.Results:  Image analysis showed that the effectiveness and ease with which the subject used the device significantly improved with practice. The questionnaire data showed that a majority of the subjects appreciated the device after the first and second time. While there was no significant decrease in time required to place and remove dentures even with the device, the area and circumference of the movement on 2‐D images were significantly reduced.Conclusion:  In this study, the utility of denture placement and removal devices was evaluated both subjectively and objectively. Our data reveal that the device is effective in the elderly. Further minor improvement in the device might be required to increase its effectiveness.
Influence of dental treatment on physical performance in community‐dwelling elderly persons
Authors: Moriya Shingo , Tei Kanchu , Murata Ayumi , Sumi Yasunori , Inoue Nobuo , Miura Hiroko 
Published: October 2011

doi: 10.1111/j.1741‐2358.2011.00563.x

Influence of dental treatment on physical performance in community‐dwelling elderly personsObjective:  The aim of the study was to investigate the influence of dental treatment on physical performance (muscle strength and balance function) among the elderly.Background:  Oral conditions have been associated with physical performance. We hypothesised that improved oral conditions by dental treatment would lead to improved physical performance.Methods:  A total of 154 persons aged 65 years or over were judged to be in need of dental treatment as a result of dental examination; of these, 121 persons underwent dental treatment. After 1 year, differences in each parameter of physical performance before and after the intervention were evaluated using the Wilcoxon signed rank sum test. The Spearman rank correlation coefficient was calculated to examine correlations between changes in self‐assessed masticatory ability (masticatory ability) and each parameter of physical performance, and multivariate logistic regression analysis was performed using changes in each parameter of physical performance as the dependent variable and changes in masticatory ability as the principal independent variable.Results:  Improved physical performance was not observed for the total study population with dental treatment; however, in subjects with improved masticatory ability, one‐leg standing times with eyes open increased significantly. A significant correlation was established between changes in masticatory ability and each parameter of physical performance. These relationships were not found in those without dental treatment. A significant relationship was also established for one‐leg standing time after adjusting for age, gender, dentition status and needs of dental treatments.Conclusion:  Chewing ability may be a positive contributing factor to balance function among the elderly.
Attitudes and usage of denture adhesives by complete denture wearers: a survey in Greece and the Netherlands
Authors: Polyzois Gregory L. , de Baat Cees 
Published: October 2011

doi: 10.1111/j.1741‐2358.2011.00566.x

Attitudes and usage of denture adhesives by complete denture wearers: a survey in Greece and the NetherlandsObjective:  To explore whether there are differences in usage of and attitudes towards denture adhesives among patients in two countries.Background:  There are no multi‐country surveys concerning usage of and attitudes towards denture adhesives from complete denture wearers.Materials and methods:  The survey took place in Greece and the Netherlands with a sample of 284 and 165 consecutive complete denture wearers, respectively, by using a 9‐item prepared questionnaire. Statistical analysis relied on chi‐square test at α = 0.05.Results:  In this survey, 26 and 20% of Greek and Dutch patients, respectively, had tried denture adhesive, but only 27% of them in Greece as well as in the Netherlands currently used it; 49% of the Greek and 45% of the Dutch participants rated the overall performance of adhesives as good. Between the two populations, no differences were identified in a majority of the research variables, except where 27% of Greeks answered that they did not know the existence of denture adhesives compared to none of the Dutch patients and when 90% of the Dutch contrary to 70% of Greeks reported that they did not need denture adhesives as they could manage their dentures well.Conclusion:  The usage of and attitudes towards denture adhesives between the Greek and Dutch sample were similar with only two exceptions concerning the knowledge of existence and the need of using denture adhesives.
Simultaneous Penile Lengthening and Penile Prosthesis Implantation in Patients with Peyronie’s Disease, Refractory Erectile Dysfunction, and Severe Penile Shortening
Authors: Sansalone Salvatore , Garaffa Giulio , Djinovic Rados , Egydio Paulo , Vespasiani Giuseppe , Miano Roberto , Loreto Carla , Ralph David J. 
Published: October 2011

ABSTRACT

Introduction
Due to loss of length, patients who had penile prosthesis implantation for Peyronie’s disease (PD) show a statistically significant reduction in their levels of satisfaction when compared with the general implant population.

Aim
The aim of this study is to report our experience of penile lengthening with circumferential graft during penile prosthesis implantation in patients with PD and severe penile shortening.

Methods
Between March 2006 and February 2008, 23 patients with PD, refractory erectile dysfunction, and severe penile shortening underwent penile lengthening with circumferential graft and concomitant implantation of an inflatable penile prosthesis.

Main Outcome Measures
Surgical outcome and complications have been recorded during postoperative follow-up. Patients’ satisfaction has been assessed 6 months postoperatively with the administration of the modified Erectile Dysfunction Index of Treatment Satisfaction (EDITS) questionnaire.

Results
After an average follow-up of 22 months (range 6–36), 20 patients attended all the postoperative follow-up visits and returned the EDITS questionnaire. An average length gain of 2.8 cm (range 2.2–4.5) was recorded, and all patients were able to cycle the device and engage in penetrative sexual intercourse. Patient recorded complications included diminished glans sensitivity in four (20%) and persistent dorsal curvature of less than 15° in three (15%). Overall, 18 patients (90%) were satisfied with the cosmetic and functional result of surgery.

Conclusion
Penile lengthening with circumferential graft during penile prosthesis implantation in patients with PD represents a safe and reproducible technique that yields higher satisfaction rates than penile prosthesis implantation alone in patients with severe penile shortening.
Psoriasis and the Risk of Erectile Dysfunction: A Population-Based Case-Control Study
Authors: Chung Shiu-Dong , Keller Joseph J. , Chu Thomas Waitao , Lin Herng-Ching 
Published: October 2011

ABSTRACT

Introduction
Psoriasis is associated with systemic metabolic and cardiovascular disorders, both of which share risk factors with erectile dysfunction (ED). However, few studies have investigated the association between ED and psoriasis.

Aim
This study set out to estimate the association between ED and having previously been diagnosed with psoriasis by using a population-based dataset with a case-control design.

Methods
This study used administrative claim data from the Taiwan National Health Insurance program. We identified 4,606 patients with ED as the study group and randomly selected 13,818 patients as the comparison group. Conditional logistic regression was used to examine the association between ED and having previously received a diagnosis of psoriasis.

Main Outcome Measure
The prevalence and risk of psoriasis between cases and controls were calculated.

Results
Of the sampled patients, 136 (0.7%) had been diagnosed with psoriasis before the index date: 77 (1.7% of the cases) were from the study group and 59 (0.4% of controls) were from the control group. Conditional logistic regression analysis revealed that after adjusting for the patient’s monthly income, geographic location, hypertension, diabetes, hyperlipidemia, coronary heart disease, obesity, and alcohol abuse/alcohol dependence syndrome status, patients with ED were more likely to have been diagnosed with psoriasis before the index date than controls (odds ratio = 3.85; 95% confidence interval = 2.72–5.44).

Conclusions
There was an association between ED and prior psoriasis. The results of this study highlight a need for clinicians dealing with psoriasis patients to be alert to the development of ED.
Sexual Functioning in Women and Men with Fibromyalgia
Authors: Rico-Villademoros Fernando , Calandre Elena P. , Rodríguez-López Carmen M. , García-Carrillo Jocelyne , Ballesteros Javier , Hidalgo-Tallón Javier , García-Leiva Juan M. 
Published: October 2011

ABSTRACT

Introduction
Sexual dysfunction has been associated with several chronic pain conditions, including fibromyalgia. However, the literature on sexual functioning in patients with fibromyalgia is limited and restricted to female patients.

Aim
The aim of our study was to evaluate sexual functioning in female and male patients with fibromyalgia compared with healthy controls.

Main Outcome Measure
Sexual functioning was evaluated using the Spanish validated version of the Changes in Sexual Functioning Questionnaire (CSFQ).

Methods
We used baseline data from several studies performed in adult patients with fibromyalgia (American College of Rheumatology criteria) of both sexes in which sexual functioning was included in the clinical evaluation. As a control group, we selected an age-matched group of healthy subjects. We calculated the proportion of patients exhibiting sexual dysfunction (i.e., a CSFQ total score equal to or lower than 41 in females and 47 in males). CSFQ scores for patients and controls were compared, and the effect sizes for the difference of means were calculated.

Results
Our sample comprised 293 patients with fibromyalgia (276 females and 17 males) and 86 healthy controls (72 females and 14 males). The frequency of sexual dysfunction was significantly higher in patients with fibromyalgia than in controls for both females (86.9% vs. 23.6%; relative risk [RR] 3.7, 95% confidence interval [CI], 2.4–5.6) and males (76.5% vs. 6.7%; RR 11.5, 95% CI, 1.7–77.6). We found significantly worse sexual functioning for all dimensions in both female and male patients with fibromyalgia. Effect sizes for the difference in mean scores of the CSFQ were large overall and for all dimensions in both females and males.

Conclusion
Our results show that sexual dysfunction is common in patients with fibromyalgia. The disease seems to deeply affect all dimensions of sexual functioning in both females and males.
Normal Inhibin B Levels Suggest Partial Preservation of Gonadal Function in Adult Male Patients with Anorexia Nervosa
Authors: Galusca Bogdan , Leca Viviane , Germain Natacha , Frere Delphine , Khalfallah Yadh , Lang Francois , Estour Bruno 
Published: October 2011

ABSTRACT

Introduction
The impact of undernutrition on endocrine and exocrine gonadatrope function is poorly known in male anorexia nervosa (AN) patients.

Aim
The aim of this study was to compare the pituitary–gonadal function of male AN subjects with that of healthy controls, Kallmann syndrome (KS) patients, and female AN subjects.

Methods
Observational monocentric cross-sectional study performed in 31 male and 25 female subjects with restrictive-type AN, 22 male and 20 female controls, and nine male KS patients.

Main Outcome Measures
Hormonal parameters are as follows: follicule stimulating hormone (FSH), luteinizing hormone (LH), sex hormone binding globulin, estradiol, testosterone, inhibin B, thyroid hormones, growth hormone (GH), insulin-like growth factor 1 (IGF-1), cortisol, adrenocorticotropic hormone (ACTH), dehydroepiandrosterone sulfate, and leptin.

Results
Similar abnormalities of free T3, GH, IGF-I, cortisol, and leptin were found in men as in AN women with equivalent undernutrition status when compared with corresponding controls. Low levels of LH, FSH were found in both male and female AN patients. In male AN, total testosterone was found lower than in controls but higher than in KS, while a lack of estradiol was noticed in AN women. Sex hormones variations were directly related to weight gain only in AN men. No relationship was found between sex hormones and leptin variation for both sexes. In AN men, inhibin B levels were similar to that of controls and did not correlate with testosterone levels.

Conclusions
Significant differences of undernutrition impact on gonadal status were noticed between male and female AN subjects, including partial preservation of testosterone release and probable preservation of exocrine function, according to the normal inhibin B levels.
Persistent Genital Arousal Disorder: Successful Treatment with Duloxetine and Pregabalin in Two Cases
Authors: Philippsohn Susanne , Kruger Tillmann H.C. 
Published: October 2011

ABSTRACT

Introduction
Persistent genital arousal disorder (PGAD) is a rare condition in women that causes a lot of suffering. The pathophysiology is not well understood and an approach promising effective treatment has not been established so far.

Aim
This study aims to make colleagues aware of two treatment options, which proved to be successful in one case each and which might be worth further investigation.

Main Outcome Measures
Subjective distress from unwanted sexual arousal, unwanted orgasms, and pain in the genital area.

Methods
Treatment of two women—36 and 41 years old—suffering from PGAD with duloxetine and pregabalin, respectively.

Results
In both women, the treatment proved to be very successful over a long period of time. One of them experienced full remission (duloxetine) and the other one experienced substantial improvement (pregabalin), over a period now lasting for more than a year.

Conclusion
Pregabalin and duloxetine, in particular, should be further investigated as possible medication for the treatment of PGAD.
Laparascopic Capsulotomy to Treat Autoinflation of Inflatable Penile Prostheses
Authors: Abbosh Phillip H. , Thom Matthew R. , Bullock Arnold 
Published: October 2011

ABSTRACT

Introduction
Inflatable penile prosthetic implants are a reliable treatment for erectile dysfunction. Mechanical failures now are the most common reason for revision of this type of device, and autoinflation is a common cause for device revision. There are currently no published surgical treatments for this malfunction.

Aim
To describe a simple outpatient surgical revision for an automatically inflating device using laparascopic dissection.

Main Outcome Measures
Complete deflation of penile prosthesis on follow-up visit, intraoperative and postsurgical complications, and length of procedure.

Methods
We performed a retrospective review of patients treated for inflatable penile prosthesis autoinflation with laparascopic capsulotomy to release constricting connective tissue rind surrounding the device reservoir at a single institution. We collected information about etiology of impotence, surgical procedures relating to implant and revision of prosthetic devices, and follow-up evaluations.

Results
Four patients underwent laparascopic capsulotomy to treat autoinflation. Mean operative time was 45 minutes, and no adverse surgical or perioperative outcomes occurred. All four patients had deflated corporal cylinders at the time of follow-up evaluation.

Conclusions
Laparascopic capsulotomy is an easy and reliable method of treating inflatable penile prosthesis autoinflation that can be performed in the outpatient setting.
Consultation and Treatment History and Causal Attributions in an Online Sample of Women with Lifelong and Acquired Vaginismus
Authors: Reissing Elke D. 
Published: October 2011

ABSTRACT

Introduction
Very little information is available on the consultation and treatment histories of women with lifelong and acquired vaginismus.

Aim
This study was conducted to address three areas of interest: first, to collect information on which health care professionals women with acquired and lifelong vaginismus consult and how helpful such consultation were; second, to examine which treatments were typically received and how helpful patients rate such interventions; and third, to explore participants’ causal attributions of the vaginal penetration problems as those are what appear to guide patients towards consulting specific health care professionals as well as affecting the openness towards different interventions.

Methods
An online survey was conducted with 212 participants. Data were analyzed using the responses of 93 women with acquired vaginismus and 75 women with lifelong vaginismus.

Main Outcome Measures
The main outcomes were the results of the online survey.

Results
Gynecologists and family doctors were most frequently consulted, but only gynecologists were rated as helpful. Psychologists and sex therapists were also frequently consulted and rated as helpful. Physiotherapists were consulted by fewer women but considered most helpful. Women with lifelong vaginismus were significantly more likely to have received vaginal dilatation, sex education, and Kegel exercises as treatment. Women with acquired vaginismus were more likely to have received pharmacological interventions and to have tried a greater range of interventions. Educational gynecological examinations, talking about the meaning of the penetration problem, vaginal dilatation, and sex education were rated as most helpful interventions. Causal attributions were pain and fear- and disgust-based attributions for women with lifelong vaginismus.

Conclusions
Results highlight the importance of a biopsychosocial conceptualization of and multidisciplinary treatment approach to lifelong and acquired vaginismus.