bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE COHORT STUDY OF ADIPOCYTES’ SECRETORY ACTIVITY, VITAMIN D, PARATHYROID HORMONE, LEPTIN RESISTANCE AND OBESITY IN HYPERTENSIVE PATIENTS
Authors: Sydorchuk Andrii , Tymkul Diana , Sydorchuk Larysa , Voronyuk Ksenia , Sokolenko Alina , Yarynych Yulia , Semianiv Marianna , Repchuk Yulia , Kazantseva Tania , Petrynych Oksana , Ivaschuk Serhii , Sydorchuk Ruslan 
Published: May 2024

Objective:
Obesity is a major risk factor of essential arterial hypertension (EAH). Therefore, we studied the dependence of 25-OH vitamin D (VitD), parathyroid hormone (PTH), Adiponectine, Leptin and ionized calcium blood values on Obesity degrees in EAH patients.

Design and method:
Study involves 100 EAH patients with hypertensive-mediated organ damage (moderate-very-high cardiovascular risks, aged 45-65). Obesity was determined by body mass index (BMI) >30 kg/m2: 1st obesity degree – 30-34.9 kg/m2, 2nd – 35-39.9 kg/m2, 3rd – >40 kg/m2. Serum levels of VitD and PTH studied by immunochemiluminescent method, Ca2+– by potentiometric method, Adiponectine and Leptin blood values – by ELISA. Leptin resistance (LR) index calculated by Leptin to Triglycerides Ratio (LTR). Adipocytes Secretory Activity (ASA) calculated by Leptin to BMI Ratio.

Results:
Adiponectin in EAH with obesity was lower, and leptin, on the contrary, was higher than in EAH without obesity – by 7.54-12.81% (p<0.001) and 1.75-2.63 times (p<0.001) respectively. LR and ASA indexes increased in presence of obesity 1.5-2.2 times (p<0.001) and 1.47-1.85 times (p<0.001), respectively. Adipocytokines concentration depended on the obesity: in 2nd and 3rd degrees EAH patients lower by 5.98% (p<0.001), and leptin, on the contrary, was higher by 50.18% (p<0.001), than in the case of 1st degree obesity, leading to LR and adipocytes’ secretory activity growth by 46.88% (p=0.018) and 26% (p=0.004). In EAH patients with 2nd and 3rd obesity degrees, concentration of 25(OH)VitD was lower by 18.48% (p=0.012), and PTH, was higher by 31.62% (p=0.017), than in obesity-free. Ionized calcium level did not depend on the obesity. Obesity risk in EAH elevated with blood adiponectin decrease (<75ng/ml) by 77 times [OR: 16.25-364.8; p<0.001], leptin augmentation (in women >21 ng/ml, in men >14 ng/ml) – 31 times [OR: 3.93-245.48; p<0.001], LR index increase (>15.0 U) – 5.27 times [OR: 2.04-13.60; p<0.001] and adipocytes’ secretory activity (>0.70 U) – 34.1 times [OR: 4.32-268.7; p<0.001].

Conclusions:
Low Adiponectine, Leptin elevation, LR and ASA augmentation increase the obesity risk in EAH 5-77 times (p<0.001). The 2nd and 3rd obesity degrees associate with lower 25(OH)VitD, higher PTH (p<0.05), independetly on ionized calcium.
CORRELATION OF BODY MASS INDEX (BMI) WITH SYSTOLIC AND DIASTOLIC BLOOD PRESSURE IN RURAL INDIAN PATIENTS
Authors: Inamdar Aniket 
Published: May 2024

Objective:
Body mass index (BMI) is positively and independently associated with morbidity and mortality from hypertension, cardiovascular disease, type II diabetes mellitus, and other chronic diseases. In Caucasian and Asian populations, a strong association has been depicted between BMI and mortality. Overweight and obesity increase the risks of high BP, coronary heart disease, ischemic stroke, type II diabetes mellitus, and certain cancers. Worldwide, about 58% of diabetes mellitus and 21% of ischemic heart disease are attributable to BMI above 21 kg/m2. The combination of blood pressure and Body Mass Index (BMI) contribute more than 60% cases of cardiovascular disease. The main objective was to determine the correlation between BMI and blood pressure of rural Indian patients.

Design and method:
This cross sectional study used 310 patients who visited our hospital in rural India from January 15,2021 to February 15,2021. Data were collected directly by measuring the blood pressure, weight and height to determine BMI. BMI was derived from booking weight (kilograms) and height (meters). Using this, the patients were categorized as underweight (<18.5 kg/m2), normal or lean BMI (18.5–22.9 kg/m2), overweight (23.0 –24.9 kg/m2) and obese (> 25 kg/m2) based on the revised consensus guidelines for India. Descriptive analysis and Spearman correlation test were used to analyze the data.

Results:
The results of the bivariate analysis using Spearman correlation test showed that there was significant relationship between BMI and systolic blood pressure (p < 0.001, r = 0.375) or diastolic blood pressure (p <0.001, r = 0.432). This study shows that higher BMI was associated with increase in systolic as well as diastolic blood pressure.

Conclusions:
This study shows statistically significant relationship between Body Mass Index (BMI) and systolic and diastolic blood pressure in rural Indian patients. Weight gain seems to be an important risk factor for development of hypertension. Weight loss has been recommended for obese hypertensive patients and has been shown to be most effective non pharmacological treatment approach. Physical activity and caloric restriction should be promoted to control the obesity epidemic which will significantly reduce global cardiovascular disease burden.
EFFECT OF GLP-1 RECEPTOR AGONISTS ON OFFICE BLOOD PRESSURE LEVELS AMONG OVERWEIGHT OR OBESE SUBJECTS TREATED WITH ANTIPSYCHOTIC DRUGS: A META-ANALYSIS
Authors: Patoulias Dimitrios , Imprialos Konstantinos , Stavropoulos Konstantinos , Koufakis Theocharis , Karakasis Paschalis , Varouktsi Anna , Zografou Ioanna , Katsimardou Alexandra , Petidis Konstantinos , Doumas Michael 
Published: May 2024

Objective:
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) constitute a drug class primarily developed for the treatment of subjects with type 2 diabetes. Subjects suffering from psychotic disorders and receiving antipsychotic drug treatment are prone to developing obesity, which is a major contributing factor to elevated blood pressure (BP) levels. Herein we sought to determine whether treatment with GLP-1RAs among overweight/obese subjects treated with antipsychotic drugs has any beneficial impact on BP levels.

Design and method:
We searched PubMed and the Cochrane Library from inception to 1 December 2022, for randomized controlled trials (RCTs) enrolling obese or overweight adult subjects with an underlying psychotic disorder treated with antipsychotic drugs, randomized either to GLP-1RAs or control. Effect of GLP-1RA treatment on office systolic and diastolic BP (SBP and DBP, respectively) levels was assessed.

Results:
We pooled data from 4 RCTs (2 utilizing liraglutide and 2 utilizing exenatide) in a total of 199 enrolled subjects. GLP-1RA treatment compared to control resulted in a non-significant effect on office SBP (p = 0.47). Similarly, GLP-1RA treatment compared to control failed to produce a significant decrease in office DBP (p = 0.53).

Conclusions:
Despite their significant weight loss properties in overweight or obese subjects, preliminary evidence suggests that GLP-1RAs do not confer a significant effect on BP levels among overweight/obese subjects treated with antipsychotic drug classes. Further, large-scale trials are required to clarify this interesting clinical aspect.
LEVELS OF MICRO RNA-21-3R IN THE BLOOD OF HYPERTENSIVE PATIENTS WITH NORMAL BODY WEIGHT AND WITH ABDOMINAL OBESITY
Authors: Koval Sergiy , Mysnychenko Olga , Penkova Marina , Lytvynov Vadim , Lytvynova Olga 
Published: May 2024

Objective:
The combination of arterial hypertension (AH) with abdominal obesity (AO) significantly increases the severity of hypertension and accelerates the development of hypertension-mediated organ damage, in particular, left ventricular hypertrophy (LVH). MicroRNAs are small non-coding RNA molecules that are involved in the regulation of post-transcriptional gene expression. A number of experimental studies have revealed the antihypertensive, antihypertrophic and antifibrosing properties of microRNA-21-3p. The goal is to study the plasma levels of microRNA-21-3p in hypertensive patients with normal body weight (NBW) and with abdominal obesity (AO).

Design and method:
27 patients (16 men) with stage 2-3 hypertension (13 with NBW and 14 with stage II AO) aged from 42 to 60 years were examined. The control group consisted of 12 practically healthy individuals. All patients underwent general clinical laboratory and instrumental examination. Circulating plasma microRNA-133a levels were obtained by polymerase chain reaction using the CFX96 Touch System, “TaqMan microRNA Assay” and “TaqMan® Universal PCR Master Mix” reagent kits.

Results:
A significant decrease in the levels of micoRNA-21-3p in the blood plasma was established in the whole group of patients with hypertension (with NBW and with AO) (1.43±0.08), p<0.05) in comparison with practically healthy individuals (3.24 ±0.07). At the same time, the levels of this miRNA in the blood plasma of patients with hypertension and AO (1.13±0.06) were significantly lower (p<0.05) than in patients with hypertension and NBW (1.67±0.07). A correlation analysis revealed negative correlations between the levels of micoRNA-21-3p in the blood plasma and the levels of “office” systolic blood pressure (R=-0.44; p=0.04), as well as the left ventricular myocardial mass index (LVMMI) (R= -0.38; p=0.03) in the whole group of patients with AH (with NBW and AO).

Conclusions:
The results of this study may indicate the presence of a significant deficiency in the production of mircRNA-21-3p in patients with hypertension, especially when it is combined with AO, as well as the involvement of this miRNA in the mechanisms of progression of hypertension and the development of LVH.
THE IMPACT OF TRANSCATHETER AORTIC VALVE REPLACEMENT ON THE DYNAMICS OF ARTERIAL HYPERTENSION IN THE ELDERLY
Authors: Moroz Simina Mariana , Nisulescu Daniel -Dumitru , Baba Mirela , Mozos Ioana , Feier Horea , Lighezan Daniel Florin , Paduraru Denisa Andreea 
Published: May 2024

Objective:
Aortic stenosis is a common heart condition characterized by the narrowing of the aortic valve, which obstructs blood flow from the heart to the rest of the body. Aortic stenosis patients undergo surgical aortic valve replacement, however, for patients at high surgical risk, transcatheter aortic valve replacement (TAVR), a minimally invasive procedure, has become an option. The present study aims to investigate the blood pressure (BP) response following transcatheter aortic valve replacement.

Design and method:
A retrospective analysis was conducted on a cohort of 90 patients (44 men and 46 women), who underwent TAVR between 2020-2023 in our Institute of Cardiovascular diseases. Statistical analysis was performed using MedCalc Statistical Software version 20.015 (MedCalc Software Ltd, Ostend. Belgium). BP was monitored in patients who underwent TAVR before the intervention and on the day of discharge. Clinical parameters and medical treatment were recorded during hospitalization. Patients were stratified according to their gender and post-procedural systolic and diastolic BP.

Results:
Mean systolic BP at admission in men was 130.56mmHg (95% C.I:125.0693 to 136.0671), versus post-procedural mean systolic BP of 124.00 mmHg (95% C.I: 118.6611 to 129.3389), p=0.0423; mean diastolic BP at admission in men was 75.29 mmHg (95% C.I: 71.5554 to 79.0355) versus post procedural mean diastolic BP of 70.34 mmHg (95% C.I: 66.8553 to 73.8265), p=0.0343. In female participants, mean systolic BP at admission was 135.19 mmHg (C.I: 127.9948 to 142.3965) and post-procedural mean systolic BP dropped to 126.34 mmHg (95% C.I: 121.4238 to 131.2719), p= 0.0094; mean diastolic BP at admission was 73.11 mmHg (95% C.I: 69.2552 to 77.0057), post-procedural mean diastolic BP was 67.73 mmHg (95% C.I: 64.1660 to 71.3123), p=0.0034. There were no statistically significant differences in the adjustment of the post-interventional medication, p=0.1823.

Conclusions:
TAVR is a revolutionary treatment for aortic stenosis demonstrating potential benefits in reducing blood pressure. By eliminating the obstruction caused by aortic stenosis, TAVR improves blood flow, enabling a potential decrease in blood pressure levels, regardless of gender.
CARDIOVASCULAR DISEASES AND CHRONIC PAIN SYNDROM CONCOMITANT IN OLDER PATIENTS: DO THEY PAY ATENTION TO SAFETY OR PRICE OF NSAIDS?
Authors: Mohammadi Reihaneh , Mohammadi Fatemmeh 
Published: May 2024

Objective:
cardiovascular diseases(CVD) such as hypertension or heart failure is a common condition in older patients which need chronic medical and non-medical treatment, lifestyle changes, and specific avoidance. older patients are suffering from different chronic diseases as osteoarthritis. NSAIDs usage have proved complications in CVD, while is a common choice for pain management in chronic pain syndrome. In this study we aimed to evaluate the prevalence of Non-steroidal anti-inflammatory drugs (NSAIDs) usage and their complications in older patients with CVD and osteoarthritis.

Design and method:
this was a cross-sectional study in older> 65 years old CVD patients in Kolur, Khalkhal, Iran. we selected CVD patients, their demographic data as age, literacy, and income from electronic health data services and made phone calls to seek about their NSAIDs or other analgesic drugs usage, other comorbidities as chronic pain syndromes, and effectiveness of drugs in pain reduction. There was a pre-designed checklist which used during phone call by a medical doctor. Also the price and insurance coverage of drugs were extracted.

Results:
the results showed 56% population or older patients with a rural lifestyle, 55% of them are hypertensive or having other CVD. 43.5% of them are using NSAIDs to relieve pain, chronically or intermittent. the most common NSAID is Diclofnac with 78.9% which is not recommended in congestive heart disease. it is a low price drug and could be sell without medical prescription in pharmacies.

Conclusions:
Diclofenac is a common NSAID used among CVD patients due to its low price than safer drugs as Naproxen. Having a happy and healthy life during older age with all these comorbidities needs education and policy adjustment. thus, patients training on over the counter drugs is important as always, specially in lower income people who will chose the most available option.
HYPERTENSION IN CARDIO-ONCOLOGY: SURVEY AMONG CARDIOLOGY FELLOWS IN TRAINING
Authors: Farhan Hasan Ali , Yaseen Israa Fadhil 
Published: May 2024

Objective:
To evaluate cardio-oncology knowledge among cardiology fellows in training (FIT).

Design and method:
A survey-based multiple choice questions study was conducted among cardiology FIT in June 2022 at a cardiology training center. The survey included five questions about management of cardiovascular diseases in patients with cancer. The questions and the correct answers are shown in Table 1. Google form was used for the survey and the link of the survey was shared with the cardiology FIT in a closed group on WhatsApp.

Results:
Total number of responses was 20, including 12 (60%) third year, 3 (15%) second year, and 5 (25%) first year cardiology FIT. The least correct answer was for question 4 which was about the cutoff value of blood pressure to re-initiate tyrosine kinase inhibitors (TKI) for patients with cancer who developed high blood pressure (>180/110 mmHg) related to TKI and for whom TKI was withheld. Most of the cardiology FIT (85%) chose the option (blood pressure <140/90 mmHg) and only (5%) chose the correct answer which is (<160/100 mmHg).

Conclusions:
Cardiology FIT need training and education in the field of cardio-oncology particularly for the management of hypertension related to cancer therapy. Identifying the cutoff value of blood pressure to re-initiate cancer therapy is one of the very important points as the delay in re-initiate cancer therapy can lead to metastasis of cancer.
SUBCLINICAL HYPERTENSION-MEDIATED ORGAN DAMAGE AND PROGNOSIS IN PATIENTS WITH HYPERTENSIVE EMERGENCIES AND URGENCIES: REPORT FROM THE ONGOING MULTICENTER ERIDANO STUDY
Authors: Cesareo Marco , Vallelonga Fabrizio , Sanapo Martina , Leone Dario , Lupia Enrico , Morello Fulvio , Totaro Silvia , Aggiusti Carlo , Salvetti Massimo , Ioverno Antonella , Maloberti Alessandro , Fucile Ilaria , Cipollini Franco , Nesti Nicola , Mancusi Costantino , Pende Aldo , Giannattasio Cristina , Muiesan Maria Lorenza , Milan Alberto 
Published: May 2024

Objective:
Acute hypertensive disorders (namely hypertensive urgencies [HU] and hypertensive emergencies [HE]) are challenges for the Emergency Department (ED) and hypertension experts. The ongoing prospective multicenter study Eridano aims to characterize patients with HE and HU, prevalence of subclinical hypertension-mediated organ damage (HMOD), and short- and long-term prognosis.

Design and method:
Patients admitted to the ED with symptomatic blood pressure (BP) > or = 180/110 mmHg were enrolled. They were managed by ED personnel according to their clinical presentations. They subsequently underwent clinical evaluation and subclinical HMOD assessment at a Hypertension Center within 72h from enrolment, and then clinical follow-up at 3 and 12 months. The endpoints considered were new HU and HE, acute coronary syndrome (ACS), acute aortic syndrome (AAS), stroke, and heart failure hospitalization.

Results:
258 patients were enrolled until October 2023. Mean age was 60±15 years, 130 (50%) were females. 28 (11%) and 230 (89%) patients were diagnosed with HE and HU, respectively. Mean systolic and diastolic BP at ED admission were 189±24 and 105±18 mmHg, respectively. BP values <180/110 mmHg were achieved in 57% and 91% of HE and HU patients, respectively. Mean systolic and diastolic BP at 72h visit were 148±22 and 87±15 mmHg, respectively, and 35% of patients were normotensive. The overall prevalence of subclinical HMOD in at least one site was 74%. The most frequent was cardiac HMOD (41%), followed by vascular (36%), cerebral (25%), and renal (13%) ones. HE patients had higher prevalence of cardiac, cerebral, and renal HMOD than HU patients (p<0.01 for all), while vascular HMOD was similar. 194 patients underwent 3 months follow-up and 113 patients completed 12 months follow-up. A total of 30 events occurred (12%), namely 21 HU, 4 ACS, 2 stroke, 1 HE, and 2 deaths. Five HE patients (18%) and 25 HU patients (11%) experienced at least one events.

Conclusions:
Subclinical hypertension-mediated organ damage is highly prevalent in patients with acute blood pressure disorders. The heart is the most frequent location involved in subclinical HMOD. Hypertensive emergencies and urgencies carry high risk of recurrent BP disorder and cardiovascular complications.
ARTERIAL HYPERTENSION IN PATIENTS LONG TERM AFTER LIVER TRANSPLANTATION
Authors: Adamczak Marcin , Romanowska Barbara , Sarna Dominika , Gojowy Damian , Karkoszka Henryk , Musialik Joanna , Wiecek Andrzej 
Published: May 2024

Objective:
Cardiovascular diseases are one of the most frequent causes of death of patients after liver transplantation (LTx). The aim of this retrospective clinical study was to estimate the prevalence of arterial hypertension among patients after successful LTx.

Design and method:
Two hundred forty three patients, aged 49.5±11.7 years (91 women, 152 men) after successful LTx who completed 24 months follow-up were studied. Diagnosis of hypertension was based on the following criteria: office blood pressure equal or higher thab 140/90 mmHg during two separate visit or use of antihypertensive pharmacotherapy. Results are presented as means with standard deviation.

Results:
The prevalence of hypertension in patients before LTx was 28.8%. Twenty four months after LTx the prevalence of hypertension increased significantly to 67.5% (p<0.001, Q Cochrane test). Therefore, annual incidence for arterial hypertension during 24 months after LTx was 18.5%. Systolic and diastolic blood pressure 24 months after LTx were 135.3 ± 18.1, and 86.4 ± 10.7 mmHg, respectively. Number of patients treated with immunosuppressive regimen based on tacrolimus or cyclosporine A or everolimus were 204 (84%), 22 (9%) and 17 (7%), respectively. Prevalence of arterial hypertension in patients treated with immunosuppressive regimen based on tacrolimus, cyclosporine A or everolimus was 63.7%, 86.4% and 88.2% respectively (p=0.01; tacrolimus vs cyclosporine p=0.03; tacrolimus vs everolimus p=0.04). Patients with arterial hypertension were treated with 1.7 ± 1.2 antihypertensive drugs. Beta-adrenergic antagonists were used by 52.2%, calcium channel antagonists by 40.9%, diuretics by 32.1%, angiotensin converting enzyme inhibitors by 28.3%, angiotensin 2 receptor antagonists 8.2% and alfa-adrenergic antagonists by 6.3% patients with arterial hypertension.

Conclusions:
1. Arterial hypertension occurs in nearly 70% of patients long term after LTx. 2. Immunosuppressive regimen might influence the prevalence of arterial hypertension in liver transplant recipients. 3. High prevalence of arterial hypertension in patients after LTx needs special attention and specific treatment in order to reduce increased cardiovascular morbidity and mortality observed in these patients.
A NOVEL METHOD FOR THE ANALYSIS OF RENAL SYMPATHETIC NERVE ACTIVITY FROM MULTI-FIBER NERVE RECORDINGS
Authors: Rodionova Kristina , Ditting Tilmann , Cordasic Nada , Hilgers Karl -Friedrich , Schiffer Mario , Amann Kerstin , Ditting Tilmann 
Published: May 2024

Objective:
Measurement of renal sympathetic nerve activity (RSNA) via bipolar electrodes from multi-fiber preparations in various species has been used for decades in the context of autonomic regulation research. Traditionally, raw neurograms are usually integrated over short time intervals and this approach works perfectly for the analysis of dynamic RSNA changes due to acute intervention. However, comparability of baseline activities between groups is limited. We present a novel analysis method, based on the raw neurogram sampled at rate of 25 kHz.

Design and method:
For RSNA-burst analysis a software based programmable algorithm was used. Continuous activities longer than three single spikes (i.e., >8ms) were defined as bursts, followed by silent periods with some single spikes. Approximately 10.000 bursts/rat were analyzed and burst amplitude, burst duration, burst area (i.e., duration integral), as well as the burst frequencies were analyzed.

Results:
In rats with myocardial infarction (n=11) we found no difference in integrated baseline RSNA as compared to controls ((n=10). However, the new method revealed higher higher burst rate per cardiac cycle [CC] (2.65 ± 0.39 vs. 1.61 ± 0.38 bursts/CC; P<0.001) and burst frequency (15.09 ± 2.42 vs. 8.52 ±1.54 Hz; P<0.001) compared to healthy controls, indicating increased RSNA.

Conclusions:
Our new method of RSNA baseline analysis was able to detect subtle differences between groups of animals that could not be detected by the traditional method of integrated RSNA analysis. Furthermore, this method has the potential to give further insights into RNSA patterns and synchronization to afferent regulatory input form the kidney itself or other organs.