bluuebunny/crossref_metadata_2025_split huggingface dataset:
Within‐ and across‐province agglomeration of LEED certifications in China
Authors: Ding Guanzu , Lin Wei , Wang Yanfei 
Published: June 2024

AbstractThis paper investigates the adoption patterns of Leadership in Energy and Environmental Design (LEED) certification in China, analyzing data from 2010 to 2021. We find that builders' choices of certification levels are positively correlated within each province. However, for commercial buildings, builders differentiate from each other in the choice of certification levels. The study also identifies spatial spillovers of LEED certification across nearby provinces. We propose potential explanations for these findings and discuss their policy implications. The results suggest that the design of certification schemes should account for the strategic behavior of firms. Additionally, regional policies promoting green building certifications may have spillover effects, encouraging adoption in neighboring regions.
Association between oral frailty and Prevotella percentage in the oral microbiota of community‐dwelling older adults who participated in the CHEER Iwamizawa project, Japan
Authors: Kimura Chizuru , Miura Kazuhito , Watanabe Yutaka , Baba Haruhisa , Ozaki Kimiya , Hasebe Akira , Ayabe Tokiyoshi , Nakamura Kiminori , Nakaoka Shinji , Ogasawara Katsuhiko , Suzuki Teppei , Saito Hiroshi , Kimura Takashi , Tamakoshi Akiko , Yamazaki Yutaka 
Published: June 2024

AbstractBackgroundPrevotella bacteria are associated with inherent diseases of the oral cavity, such as periodontal disease, and systemic diseases. Oral frailty (OF) has been associated with nursing necessity and death. However, the relationship between OF and oral microbiota has not been fully clarified.ObjectiveThis cross‐sectional study investigated the association between OF and Prevotella percentage in the oral microbiota of community‐dwelling older adults.MethodsOral bacteria species from saliva were identified in 208 community‐dwelling older individuals aged ≥60 years in Japan. The proportion of Prevotella in the oral microbiota was classified into three tertile groups, and its relationship with each test item for OF (number of remaining teeth, masticatory performance, oral diadochokinesis, tongue pressure, difficulties eating tough foods, difficulties swallowing tea or soup, number of applicable OF judgement items, and existence of OF) was examined using ordinal logistic regression analysis.ResultsThe Prevotella proportions were classified into lower, middle and upper groups, comprising 70, 69 and 69 participants, respectively. The three groups showed a significant relationship between the number of remaining teeth (odds ratio [OR]: 0.946, 95% confidence interval [CI]: 0.915–0.977), masticatory performance (OR: 0.897, 95% CI: 0.844–0.953), number of applicable OF judgement items (OR: 1.477, 95% CI: 1.14–1.915), and existence of OF (OR: 4.194, 95% CI: 1.519–11.576).ConclusionThe proportion of Prevotella in oral microbiota was high in individuals with OF. Among the older adults, the type of oral microbiota and systemic diseases may be related to the examination and management of oral function decline.
Advancing arteriovenous fistula needling: The role of physical exam and doppler ultrasound
Authors: Pinto Rui , Barros João , Ferreira Ricardo , Alves Pedro , Sousa Rui , Oliveira Liliana , Pereira Lénia , Correia Ana Luísa , Silva Ana Rita , Henriques Andreia , Magda Guerra  , Mata Fernando , Salgueiro Anabela , Fernandes Isabel , Alves Rui , Sousa Clemente 
Published: June 2024

AbstractBackgroundThe success of haemodialysis (HD) critically depends on the effective use of arteriovenous fistulas (AVFs). The precise needling technique is vital to minimise complications and ensure functional vascular access.ObjectiveThis study assesses the effectiveness of a nursing consultation protocol, which integrates physical examination (PE) with Doppler Ultrasound (DUS), in preparing patients for the first AVF needling.Design/ParticipantsA cross‐sectional analysis at a Portuguese National Health Service Hospital engaged thirty new HD patients, four HD needling experienced nurses and one HD vascular access nurse. This study examines the accuracy of PE in assessing the matured AVF by the four nurses compared to a trained vascular access nurse encompassing systematic PE and DUS.MeasurementsThe primary data incorporated AVF characteristics derived from PE (inspection, palpation, and auscultation) and DUS findings (vein depth, diameter, and blood flow). A secondary focus was evaluating the change in nurses' perceived needling complexity following the nursing consultation.ResultsThe nursing consultation significantly enhanced the identification of crucial AVF features, such as accessory veins (p = 0.002), and improved the accuracy of AVF morphology assessments. This led to identifying longer needling tracks (p = 0.031) and a higher number of safe needling points (p = 0.016). Nurses reported a notable reduction in perceived complexity and potential adverse events following this method (p = 0.027).ConclusionsIntegrating structured PE with DUS in a nursing consultation framework significantly improves the preparation for AVF needling. This approach enhances the efficiency and safety of AVF needling and boosts nurse confidence and patient care in HD settings.
Weather conditions at different spatial and temporal scales influence avian post‐breeding migration patterns on route
Authors: Benjumea R. , Astrain C. , Istúriz A. , Oria P. , Ibarrola I. , del Mar Delgado M. 
Published: June 2024

AbstractMigration plays a central role in many ecological and evolutionary processes. Global patterns of climatic variation are having a profound influence upon animal migration patterns. Even though regular counts of bird migrations at bottleneck sites can certainly offer insights into how natural populations of different species at different scales are responding to changes in weather conditions, they have not yet been widely used. By analysing a time series of regular counts, collected during autumn, of 126 species migrating during the daytime through one of the most important migratory bottlenecks in Western Europe, we found that an increase in temperature at the regional scale, as well as a decrease in precipitation level during the breeding period, may result not only in a decrease in the migration rate during autumn but also in a delay in the timing of fall migration. Furthermore, adverse weather conditions at the local scale interrupted bird migration through the bottleneck until favourable weather conditions returned. Importantly, temporal variation in the number of migratory birds followed a nonlinear pattern, something which might be partially due to the idiosyncratic responses of migratory species with different life‐history characteristics to changes in weather conditions. Our results highlight that migration is a nonlinear, multiscale and multi‐faceted process, suggesting that it will be difficult to predict the responses of idiosyncratic migratory species to the unpredictable effects of climate change.
When words are your scalpel, what and how information is exchanged may be differently salient to assessors
Authors: Li Melissa , Kurahashi Allison M. , Kawaguchi Sarah , Siemens Isaac , Sirianni Giovanna , Myers Jeff 
Published: June 2024

AbstractPurposeVariable assessments of learner performances can occur when different assessors determine different elements to be differently important or salient. How assessors determine the importance of performance elements has historically been thought to occur idiosyncratically and thus be amenable to assessor training interventions. More recently, a main source of variation found among assessors was two underlying factors that were differently emphasised: medical expertise and interpersonal skills. This gave legitimacy to the theory that different interpretations of the same performance may represent multiple truths. A faculty development activity introducing assessors to entrustable professional activities in which they estimated a learner's level of readiness for entrustment provided an opportunity to qualitatively explore assessor variation in the context of an interaction and in a setting in which interpersonal skills are highly valued.MethodsUsing a constructivist grounded theory approach, we explored variation in assessment processes among a group of palliative medicine assessors who completed a simulated direct observation and assessment of the same learner interaction.ResultsDespite identifying similar learner strengths and areas for improvement, the estimated level of readiness for entrustment varied substantially among assessors. Those who estimated the learner as not yet ready for entrustment seemed to prioritise what information was exchanged and viewed missed information as performance gaps. Those who estimated the learner as ready for entrustment seemed to prioritise how information was exchanged and viewed the same missed information as personal style differences or appropriate clinical judgement. When presented with a summary, assessors expressed surprise and concern about the variation.ConclusionA main source of variation among our assessors was the differential salience of performance elements that align with medical expertise and interpersonal skills. These data support the theory that when assessing an interaction, differential salience for these two factors may be an important and perhaps inevitable source of assessor variation.
Lateral kangaroo position for thermal stability of extremely preterm: Non‐inferiority randomized controlled trial
Authors: Jimenez‐Fernández Lucía , Serrano‐Gutierrez Ana , Martínez‐Pérez Patricia , Melchor‐Muñoz Patricia , Fernández‐Carvajal Amalia , Campos‐Martínez Belén , Piris‐Borregas Salvador , Pont‐Vilalta María , Collados‐Gómez Laura 
Published: June 2024

AbstractBackgroundKangaroo care (KC) is an evidence‐based best practice that can prevent major health complications in preterm infants. However, there is a lack of evidence on the feasibility and safety of placing extremely preterm infants under 28 weeks gestational age in KC position.AimTo compare thermal stability 60 min after the first KC session in the lateral versus prone position in extremely preterm infants under 28 weeks gestational age.Study DesignThis is a single‐centre, randomized, non‐inferiority, parallel clinical trial. The patients were extremely preterm infants during their first 5 days of life. Infants in the intervention group received KC in the lateral position while those in the control group received KC in the prone position. All infants receiving KC were inside their polyethylene bags but maintained skin‐to‐skin contact. The primary outcome was the axillary temperature of the infants, and the secondary outcome was the development of intraventricular haemorrhage.ResultsSeventy infants were randomized (35 per group). The mean gestational age was 26 +1(1+1) in both groups. In the first KC session, the infant temperature at 60 minutes was 36.79°C (0.43) in lateral KC position, and 36.78°C (0.38) in prone KC position (p = .022). In lateral KC position, 7.69% (2) of the children who, according to the cranial ultrasound performed before the first session, had no haemorrhage presented with intraventricular haemorrhage after the first session. In prone KC position, new haemorrhages appeared after the first session in 29.17% (7) (p = .08).ConclusionsThe lateral KC position is an alternative to the conventional prone KC position and maintains normothermia in infants under 28 weeks gestational age.Relevance to Clinical PracticeExtremely preterm infants are candidates for KC. Lateral KC position is an evidence‐based best practice that can be applied to preterm infants under 28 weeks GA. This evidence is particularly useful in performing umbilical catheterization on these patients.
RcOST1L phosphorylates RcPIF4 for proteasomal degradation to promote flowering in rose
Authors: Sun Jingjing , Liu Hongchi , Wang Weinan , Fan Chunguo , Yuan Guozhen , Zhou Rui , Lu Jun , Liu Jinyi , Wang Changquan 
Published: June 2024

Summary

Flowering is a vital agronomic trait that determines the economic value of most ornamental plants. The flowering time of rose (Rosa spp.) is photoperiod insensitive and is thought to be tightly controlled by light intensity, although the detailed molecular mechanism remains unclear.

Here, we showed that rose plants flower later under low‐light (LL) intensity than under high‐light (HL) intensity, which is mainly related to the stability of PHYTOCHROME‐INTERACTING FACTORs (RcPIFs) mediated by OPEN STOMATA 1‐Like (RcOST1L) under different light intensity regimes.

We determined that HL conditions trigger the rapid phosphorylation of RcPIFs before their degradation. A yeast two‐hybrid screen identified the kinase RcOST1L as interacting with RcPIF4. Moreover, RcOST1L positively regulated rose flowering and directly phosphorylated RcPIF4 on serine 198 to promote its degradation under HL conditions. Additionally, phytochrome B (RcphyB) enhanced RcOST1L‐mediated phosphorylation of RcPIF4 via interacting with the active phyB‐binding motif. RcphyB was activated upon HL and recruited RcOST1L to facilitate its nuclear accumulation, in turn leading to decreased stability of RcPIF4 and flowering acceleration.

Our findings illustrate how RcPIF abundance safeguards proper rose flowering under different light intensities, thus uncovering the essential role of RcOST1L in the RcphyB–RcPIF4 module in flowering.
A systematic review and qualitative synthesis of weight management interventions for people with spinal cord injury
Authors: Madigan Claire D. , King James A. , Taylor Carolyn , Hoekstra Sven P. , Graham Heneritta E. , Kirk Natasha , Fenton Jordan M. , Goosey‐Tolfrey Vicky L. 
Published: June 2024

SummaryPeople with spinal cord injury (SCI) are at greater risk of developing obesity and related co‐morbidities than those without SCI. The objectives of this systematic review were to examine the effectiveness of weight management interventions for people with SCI and to synthesize the experiences of people involved with SCI weight management (e.g., SCI healthcare professionals and caregivers). Five databases were searched (up to July 31, 2023) and 5,491 potentially eligible articles were identified. Following screening, 22 articles were included, comprising 562 adults. There was considerable heterogeneity in study design and weight loss interventions included behavioral nutritional and exercise education sessions, recalling food diaries, exercise interventions, and pharmaceuticals. The mean percentage change of the pooled body mass data equated to −4.0 ± 2.3%, with a range from −0.5 to −7.6%. In addition, 38% of the individuals with SCI who completed a weight loss intervention (N = 262) had a ≥5% reduction in body weight. Collectively, although on average the included interventions led to moderate weight loss, the finding that just over a third of individuals achieved clinically meaningful 5% weight loss suggests that available interventions for this population may need to be improved.
Closed loop stimulation in left bundle branch area pacing
Authors: Dell'Era Gabriele , Ghiglieno Chiara , De Vecchi Federica , Santagostino Matteo , Annunziata Lucia , Baldassarre Irene , Giacopelli Daniele , Patti Giuseppe 
Published: June 2024

AbstractIntroductionClosed Loop Stimulation (CLS) is a rate‐responsive algorithm that adjusts heart rate (HR) based on changes in intracardiac impedance measured from the right ventricle lead. However, the use of CLS in conduction system pacing has not been investigated. In this retrospective study, we aimed to assess whether CLS with left bundle branch area pacing (LBBAP) can generate an appropriate distribution of HR in daily life.Methods and ResultsOur study included 24 patients with CLS pacing and chronotropic incompetence, comparing them with 19 patients receiving DDD pacing, all with LBBAP. Cumulative HR distribution charts were generated using data from a single device interrogation with a minimum follow‐up period of 30 days. In DDD‐CLS mode, there was a higher percentage of atrial pacing compared to DDD mode (median 58% [interquartile range 29%‐83%] vs. 13% [10%‐26%], p = .001), and CLS‐paced beats were present across all frequency bins. The distribution of beats between the groups was similar (p = .643), resulting in comparable mean HR (72 bpm [70‐77] vs. 73 bpm [65‐75], p = .615).ConclusionsIn the context of LBBAP, CLS effectively modulates pacing rates over a wide frequency range. This lead position does not adversely affect the rate‐responsive performance of the algorithm.
Social Determinants of Health and Outcomes After Pediatric Ventricular Assist Device Implantation
Authors: West Caroline L. , Zhao Hong , Cantor Ryan , Sood Vikram , Lal Ashwin K. , Beaty Claude , Kirklin James K. , Peng David M. 
Published: June 2024

ABSTRACTBackgroundLimited research exists on the influence of social determinants of health (SDOH) on outcomes in pediatric patients with advanced heart failure receiving mechanical circulatory support.MethodsLinkage of the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) and Society of Thoracic Surgeon's Congenital Heart Surgery Database (STS‐CHSD) identified pediatric patients who underwent ventricular assist device (VAD) implantation from 2012 to 2022 with available residential zip codes. Utilizing the available zip codes, each patient was assigned a Childhood Opportunity Index (COI) score. Level of childhood opportunity, race, and insurance type were used as proxies for SDOH. Major outcomes included death, transplant, alive with device, and recovery. Secondary outcomes were adverse events. Statistical analyses were performed using the Kaplan–Meier survival, competing risk analyses, and multivariable Cox proportional hazards model.ResultsThree hundred seventeen patients were included in the study. Childhood opportunity level and insurance status did not significantly impact morbidity or mortality after VAD implantation. White race was associated with reduced 1‐year survival (71% in White vs. 87% in non‐White patients, p = 0.05) and increased risk of pump thrombosis (p = 0.02).ConclusionChildhood opportunity level and insurance status were not linked to morbidity and mortality in pediatric patients after VAD implantation. Notably, White race was associated with higher mortality rates. The study underscores the importance of considering SDOH in evaluating advanced therapies for pediatric heart failure and emphasizes the need for accurate socioeconomic data collection in future studies and national registries.
Clinical Course of Nonresponders With Recurrent Focal Segmental Glomerulosclerosis After Pediatric Kidney Transplantation: A Retrospective Multicenter Study
Authors: Ban Hideki , Miura Kenichiro , Ando Taro , Shirai Yoko , Kaneko Naoto , Ishizuka Kiyonobu , Hotta Kiyohiko , Hattori Motoshi 
Published: June 2024

ABSTRACTBackgroundPrimary focal segmental glomerulosclerosis (FSGS) frequently recurs after kidney transplantation and is associated with poor graft survival. Patients who do not achieve remission (nonresponders) have an especially poor graft survival. However, the characteristics that may affect graft survival in nonresponders are unknown. This study aimed to determine the clinical characteristics associated with graft survival in nonresponders.MethodsWe retrospectively collected the clinical records of patients with FSGS and an age at onset <16 years who experienced posttransplant recurrence of FSGS at six hospitals in Japan from 1993 to 2018.ResultsEight nonresponders with recurrent FSGS were enrolled in this study. The median time to recurrence after kidney transplantation was 1 day (interquartile range, 1–2 days). All patients received therapeutic plasma exchange and methylprednisolone pulse therapy. Rituximab was used as an add‐on therapy in three patients. Five patients lost their graft within 2 years after kidney transplantation (rapid group). In contrast, three patients had much longer graft survival (nonrapid group). We compared the clinical characteristics of the rapid and nonrapid groups. Proteinuria tended to be lower in the nonrapid group at the third and subsequent months of therapy. The rapid group had persistent nephrotic syndrome. The rate of reduction in proteinuria was lower in the rapid group than in the nonrapid group.ConclusionsOur study suggests that persistent nephrotic syndrome and a low rate of reduction in proteinuria may predict rapid progression to graft failure in nonresponders.
Overcoming the effects of fluid shear stress in ovarian cancer cell lines: Doxorubicin alone or photodynamic priming to target platinum resistance
Authors: Overchuk Marta , Rickard Brittany P. , Tulino Justin , Tan Xianming , Ligler Frances S. , Huang Huang‐Chiao , Rizvi Imran 
Published: June 2024

AbstractResistance to platinum‐based chemotherapies remains a significant challenge in advanced‐stage high‐grade serous ovarian carcinoma, and patients with malignant ascites face the poorest outcomes. It is, therefore, important to understand the effects of ascites, including the associated fluid shear stress (FSS), on phenotypic changes and therapy response, specifically FSS‐induced chemotherapy resistance and the underlying mechanisms in ovarian cancer. This study investigated the effects of FSS on response to cisplatin, a platinum‐based chemotherapy, and doxorubicin, an anthracycline, both of which are commonly used to manage advanced‐stage ovarian cancer. Consistent with prior research, OVCAR‐3 and Caov‐3 cells cultivated under FSS demonstrated significant resistance to cisplatin. Examination of the role of mitochondria revealed an increase in mitochondrial DNA copy number and intracellular ATP content in cultures grown under FSS, suggesting that changes in mitochondria number and metabolic activity may contribute to platinum resistance. Interestingly, no resistance to doxorubicin was observed under FSS, the first such observation of a lack of resistance under these conditions. Finally, this study demonstrated the potential of photodynamic priming using benzoporphyrin derivative, a clinically approved photosensitizer that localizes in part to mitochondria and endoplasmic reticula, to enhance the efficacy of cisplatin, but not doxorubicin, thereby overcoming FSS‐induced platinum resistance.