bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcirculation retrograde placement of a Pipeline embolization device for treatment of a vertebrobasilar junction aneurysm
Authors: Srinivasan Visish M , Graffeo Christopher S , Scherschinski Lea , Majmundar Neil , Catapano Joshua S , Winkler Ethan A , Jadhav Ashutosh P , Ducruet Andrew F , Lawton Michael T , Albuquerque Felipe C 
Published: June 2024

Transcirculation catheterization, also known as the retrograde approach, involves the navigation of a catheter or other endovascular device from one arterial circulation to the other (right to left, or anterior to posterior).1–4 We present a case of a complex vertebrobasilar junction aneurysm previously treated by bilateral vertebral artery deconstruction, precluding antegrade access (video 1). Following the creation of a protective occipital artery to posterior inferior cerebellar artery (PICA) bypass, the patient was treated with transcirculation placement of a Pipeline embolization device (PED).5–9 The right internal carotid artery was accessed with a guide catheter using a transradial approach. The microwire–microcatheter combination was then tracked through the right posterior communicating artery, down the basilar trunk, and to the left PICA. The PED was successfully deployed from the left vertebral artery to the mid-basilar artery. At 3-month follow-up, the aneurysm was completely obliterated. The nuances of transcirculation technique, especially for flow diversion, are discussed. (Used with permission from Barrow Neurological Institute, Phoenix, Arizona, USA.)Video 1Transcirculation retrograde placement of a Pipeline embolization device for treatment of a vertebrobasilar junction aneurysm previously treated by bilateral vertebral artery deconstruction, precluding antegrade access
Lipoprotein(a), Oxidized Phospholipids, and Progression to Symptomatic Heart Failure: The CASABLANCA Study
Authors: Januzzi James L. , van Kimmenade Roland R. J. , Liu Yuxi , Hu Xingdi , Browne Auris , Plutzky Jorge , Tsimikas Sotirios , Blankstein Ron , Natarajan Pradeep 
Published: June 2024

Background
Higher lipoprotein(a) and oxidized phospholipid concentrations are associated with increased risk for coronary artery disease and valvular heart disease. The role of lipoprotein(a) or oxidized phospholipid as a risk factor for incident heart failure (HF) or its complications remains uncertain.

Methods and Results

A total of 1251 individuals referred for coronary angiography in the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study were stratified on the basis of universal definition of HF stage; those in stage A/B (N=714) were followed up for an average 3.7 years for incident stage C/D HF or the composite of HF/cardiovascular death. During follow‐up, 105 (14.7%) study participants in stage A/B progressed to symptomatic HF and 57 (8.0%) had cardiovascular death. In models adjusted for multiple HF risk factors, including severe coronary artery disease and aortic stenosis, individuals with lipoprotein(a) ≥150 nmol/L were at higher risk for progression to symptomatic HF (hazard ratio [HR], 1.90 [95% CI, 1.15–3.13];
P
=0.01) or the composite of HF/cardiovascular death (HR, 1.71 [95% CI, 1.10–2.67];
P
=0.02). These results remained significant after further adjustment of the model to include prior myocardial infarction (HF: HR, 1.89,
P=
0.01; HF/cardiovascular death: HR, 1.68,
P
=0.02). Elevated oxidized phospholipid concentrations were similarly associated with risk, particularly when added to higher lipoprotein(a). In Kaplan‐Meier analyses, individuals with stage A/B HF and elevated lipoprotein(a) had shorter time to progression to stage C/D HF or HF/cardiovascular death (both log‐rank
P
<0.001).

Conclusions
Among individuals with stage A or B HF, higher lipoprotein(a) and oxidized phospholipid concentrations are independent risk factors for progression to symptomatic HF or cardiovascular death.

Registration

URL:
https://wwwclinicaltrials.gov
; Unique identifier: NCT00842868.
The dynamics of dynamic time warping in fMRI data: A method to capture inter-network stretching and shrinking via warp elasticity
Authors: Wiafe Sir-Lord , Faghiri Ashkan , Fu Zening , Miller Robyn , Preda Adrian , Calhoun Vince D. 
Published: June 2024

Abstract
In neuroimaging research, understanding the intricate dynamics of brain networks over time is paramount for unraveling the complexities of brain function. One approach commonly used to explore the dynamic nature of brain networks is functional connectivity analysis. However, while functional connectivity offers valuable insights, it fails to consider the diverse timescales of coupling between different brain regions. This gap in understanding leaves a significant aspect of brain dynamics unexplored in neuroimaging research. We propose an innovative approach that delves into the dynamic coupling/connectivity timescales of brain regions relative to one another, focusing on how brain region couplings stretch or shrink over time, rather than relying solely on functional connectivity measures. Our method introduces a novel metric called “warping elasticity,” which utilizes dynamic time warping (DTW) to capture the temporal nuances of connectivity. Unlike traditional methods, our approach allows for (potentially nonlinear) dynamic compression and expansion of the time series, offering a more intricate understanding of how coupling between brain regions evolves. Through the adaptive windows employed by the DTW method, we can effectively capture transient couplings within varying connectivity timescales of brain network pairs. In extensive evaluations, our method exhibits high replicability across subjects and diverse datasets, showcasing robustness against noise. More importantly, it uncovers statistically significant distinctions between healthy control (HC) and schizophrenia (SZ) groups through the identification of warp elasticity states. These states are cluster centroids, representing the warp elasticity across subjects and time, offering a novel perspective on the dynamic nature of brain connectivity, distinct from conventional metrics focused solely on functional connectivity. For instance, controls spend more time in a warp elasticity state characterized by timescale stretching of the visual domain relative to other domains, suggesting disruptions in the visual cortex. Conversely, patients show increased time spent in a warp elasticity state with stretching timescales in higher cognitive areas relative to sensory regions, indicative of prolonged cognitive processing of sensory input. Overall, our approach presents a promising avenue for investigating the temporal dynamics of brain network interactions in functional magnetic resonance imaging (fMRI) data. By focusing on the elasticity of connectivity timescales, rather than adhering to functional connectivity metrics, we pave the way for a deeper understanding of neuropsychiatric disorders in neuroscience research.
Increasing hub disruption parallels dementia severity in autosomal
dominant Alzheimer’s disease
Authors: Tu Jiaxin Cindy , Millar Peter R. , Strain Jeremy F. , Eck Andrew , Adeyemo Babatunde , Snyder Abraham Z. , Daniels Alisha , Karch Celeste , Huey Edward D. , McDade Eric , Day Gregory S. , Yakushev Igor , Hassenstab Jason , Morris John , Llibre-Guerra Jorge J. , Ibanez Laura , Jucker Mathias , Mendez Patricio Chrem , Perrin Richard J. , Benzinger Tammie L. S. , Jack Clifford R. , Betzel Richard , Ances Beau M. , Eggebrecht Adam T. , Gordon Brian A. , Wheelock Muriah D. ,   the Dominantly Inherited Alzheimer Network
Published: June 2024

Abstract
Hub regions in the brain, recognized for their roles in ensuring efficient information transfer, are vulnerable to pathological alterations in neurodegenerative conditions, including Alzheimer’s disease (AD). Computational simulations and animal experiments have hinted at the theory of activity-dependent degeneration as the cause of this hub vulnerability. However, two critical issues remain unresolved. First, past research has not clearly distinguished between two scenarios: hub regions facing a higher risk of connectivity disruption (targeted attack) and all regions having an equal risk (random attack). Second, human studies offering support for activity-dependent explanations remain scarce. We refined the hub disruption index to demonstrate a hub disruption pattern in functional connectivity in autosomal dominant AD that aligned with targeted attacks. This hub disruption is detectable even in preclinical stages, 12 years before the expected symptom onset and is amplified alongside symptomatic progression. Moreover, hub disruption was primarily tied to regional differences in global connectivity and sequentially followed changes observed in amyloid-beta positron emission tomography cortical markers, consistent with the activity-dependent degeneration explanation. Taken together, our findings deepen the understanding of brain network organization in neurodegenerative diseases and could be instrumental in refining diagnostic and targeted therapeutic strategies for AD in the future.
The Openness of Death: (Re)constructing Indigenous Identity in Post–martial Law Taiwan
Authors: Beswick Billy 
Published: June 2024

Abstract
This article presents a set of interrelated close readings of works by four Indigenous Taiwanese cultural producers—the Puyuma writer Sun Dachuan, the Atayal painter Anli Genu, the Truku sculptor Labay Eyong, and the Atayal director Laha Mebow. I discuss the important symbolic role Taiwan’s Indigenous population has played in the development of a Taiwanese national imaginary and how this has affected Indigenous cultural expression. I argue that rather than trying to root out the improper intrusion of this ‘outside’ force into Indigenous cultural life, the works of these four cultural producers instead show how Indigenous identity can flourish through an honest navigation of the relationship brought about by that intrusion. They present an understanding of Indigenous identity in Taiwan as convoluted and changing, never fully in possession of itself but not any less authentic for that. My theorisation of this builds on Sun Dachuan’s notion of ‘the openness of death’, which he uses to highlight the need for Indigenous culture to transform itself in dynamic relation to the wider context in which it is embedded.
The Instruction of a Man for His Son in Finland (O. SES 23)
Authors: Christiansen Thomas , Autere Kaisa , Bueno Guardia Miriam , Salmenkivi Erja , Sola Hanna , Tambs Lena , Wasmuth Melanie 
Published: June 2024

This short article is the publication of a hieratic ostracon (O. SES 23) from the Ramesside Period in the collection of the Finnish Egyptological Society that preserves parts of the title, the exordium, and the first paragraph of The Instruction of a Man for His Son. The provenance and the exact acquisition history of the ostracon are unknown, but indirect evidence suggests that it derives from Deir el-Medina and was acquired in Luxor by the late Professor of Egyptology in Finland, Rostislav Holthoer, in the early 1970s. A textual variant in line three, also attested in another ostracon from Deir el-Medina, suggests that the first paragraph of the composition does not juxtapose the life of a scribe with that of a farmer, as is commonly believed, but instead with that of a soldier. [Formula: see text]
A current comprehensive role of immune-checkpoint inhibitors in resectable non-small cell lung cancer: A narrative review
Authors: Efil Safa Can , Bilgin Burak , Ceylan Furkan , Karakaş Hilal , Karahan İrfan , Özsan Sema Nur , Kosku Hakan , Yaman Şebnem , Bülent Akıncı Muhammed , Dede Didem Şener , Yalçın Bülent , Nahit Şendur Mehmet Ali 
Published: June 2024

Objective The objective of this article is to review the efficacy, safety, and evidence for current use and potential future uses of immune-checkpoint inhibitors (ICIs) in the management of resectable non-small cell lung cancer (NSCLC). Data sources A literature review was carried out through PubMed to identify completed and ongoing clinical trials evaluating the use, efficacy, and safety of ICIs in the management of resectable NSCLC. Data summary To date, four phase 3 trials have emerged that have changed our treatment practice concerning the utilization of ICIs during the adjuvant and neoadjuvant settings. The IMpower010 and KEYNOTE-091 trials examined the application of adjuvant atezolizumab and pembrolizumab, respectively, following surgical resection and adjuvant chemotherapy. In the CheckMate 816 trial, the combination of nivolumab and chemotherapy as a neoadjuvant therapy received approval for patients with resectable NSCLC. Also, for patients with resectable NSCLC, the use of a pembrolizumab and chemotherapy combination as a perioperative therapy received approval based on the results of the KEYNOTE-671 trial. Apart from these trials, there are numerous phase 2 and phase 3 trials, some of which have been published while others are still in progress. Conclusion Despite the promising outcomes from these trials there remain several unanswered questions. In this review, we will assess clinical trials involving adjuvant, neoadjuvant, and perioperative ICIs, aiming to address the unresolved questions related to these therapeutic approaches.
Must The Show Go On? A Qualitative Study Exploring Barriers And Enablers To Manual Therapists’ Care Of Dancers
Authors: Andrade Paula , Thomson Oliver P. 
Published: June 2024

Introduction: Dance Medicine is a growing discipline, and healthcare for dancers requires appreciating particularities of their artistic craft. Manual therapists (MTs) are often dancers’ first choice when seeking care. Whilst dancers’ experiences of injury and healthcare have been extensively researched, little is known of MTs’ perspectives of caring for them. Aim: This study aimed to gain an understanding of MTs’ perspectives of caring for dancers. Communication, treatment strategies and obstacles to a successful therapeutic alliance were examined to broaden knowledge and improve care. Methods: This was a qualitative study using Grounded Theory as a framework for data collection and analysis. A purposive sample of 8 participants was recruited—physiotherapists, chiropractors, and osteopaths with 2+ years’ experience of treating dancers. Data collection was conducted via semi-structured interviews, which were transcribed verbatim, anonymized, member checked, and later analyzed. Results: Data analysis constructed 3 categories which described the range of participants’ experiences. Two categories were identified—(i) A Strangled Industry and (ii) Be-all End-all Patients—and found to culminate in a core category: (iii) Beyond Hands-on, which exemplified MTs’ attempts to address clinical challenges. Conclusions: MTs experience several challenges when providing healthcare to dancers. These encompass psychosocial aspects relating to dancers’ internal world and the dance industry environment. It suggests that caring for dancers demands comprehensive, collaborative, and psychologically informed approaches. Emphasis should also be given to developing and implementing dance-specific pain science for all stakeholders.
Radius-Maumenee syndrome-associated glaucoma, a therapeutic challenge: A case report
Authors: Lavaris Anastasios , Petrushkin Harry , Nikita Eleni 
Published: June 2024

Introduction Radius-Maumenee syndrome is a rare cause of open-angle glaucoma, secondary to elevated episcleral venous pressure (EVP) without any orbital or systemic abnormalities. Case presentation We present a case of a male patient in his mid-sixties, who presented with bilateral dilated episcleral vessels, bilateral glaucoma, chorioretinal folds in both maculae and choroidal effusion in his left eye. Our case highlights the differentials that should be considered and the systematic investigations that should be performed. We describe the clinical, optical coherence tomography and angiography findings of this patient and propose a potential pathophysiological mechanism leading to the propensity for perioperative complications. Conclusion Radius-Maumenee syndrome should be a diagnosis of exclusion. Secondary glaucoma can remain refractory to medical treatment and filtering surgery carries the risk intra-operative or post-operative uveal effusions.
Psychological behavioral therapies to improve autistic children’s behaviors during dental visits: A systematic review and meta-analysis
Authors: Pui Ying Lam Phoebe , Hoi Wan Fok Elise , Tung Megan Chan Yuen , Ming Leung Chung , McGrath Colman Patrick , Kar Yung Yiu Cynthia 
Published: June 2024

This systematic review aimed to evaluate the effectiveness of psychological behavioral therapies to improve behaviors of autistic children during dental visits. Screening, data extraction, risk-of-bias assessment, and evaluation of certainty of evidence were performed by two independent reviewers. Eighteen studies were ultimately included. On average 56% (95% confidence interval, 33.95–78.29) and 64% (95% confidence interval 47.24–81.80) of autistic children can cooperate with dental examination with an oral mirror in the first and second visits, respectively. Visual pedagogy did not improve the proportion of autistic children who can accept dental examinations. Inconsistent results were also identified for Treatment and Education of Autistic and related Communication-handicapped CHildren, Picture Exchange Communication System, Applied Behavior Analysis, video modeling, distractions, and other conventional behavioral management techniques. Many studies were of small sample size, lacked a control group, did not account for autism spectrum disorder severity, comorbidities, previous dental experience or other confounders, and had a high risk of bias. The evidence supporting the use of psychoeducation techniques to improve the dental experience of autistic children is limited and of very low certainty. Further research with larger scale studies and appropriate control groups is needed to enhance the certainty of evidence in this field. Lay abstract This research review looked at how well different psychological behavioral therapies help improve the behavior of autistic children during dental visits. The researchers studied 18 different studies and found that, on average, about 56% of autistic children were able to cooperate with a dental exam using an oral mirror during their first visit. The number increased to about 64% during their second visit. However, using visual pedagogies or teaching aids did not seem to make a big difference in how many children could accept the dental exams. The results for other psychological behavioral techniques were also inconsistent, including Treatment and Education of Autistic and related Communication-handicapped CHildren, Picture Exchange Communication System, Applied Behavior Analysis, video modeling, and distractions. Many of the studies were small and did not include a comparison group. They also did not consider factors like how severe the autism was, other conditions the children had, or their previous dental experiences. Because of these limitations, the evidence supporting the use of psychological behavioral techniques to improve dental visits for autistic children is limited and uncertain. More research with larger studies and proper control groups is needed to better understand this topic.
Occlusive dressing versus local flap coverage for the treatment of fingertip amputations with exposed bone: a comparative study
Authors: Randazzo Laetitia , Muller Claire , Piessat Colin , Dap François , Athlani Lionel 
Published: June 2024

We retrospectively reviewed the outcomes of 54 patients treated with occlusive dressings (OD) (27 patients) or local flap (LF) coverage (28 patients) for fingertip amputations with bone exposure. All patients healed completely within a mean of 5 weeks in the OD group and 3.5 weeks in the LF group. At a mean follow-up of 26 months (range 12–38), 2-point discrimination was significantly better in the OD group (4 mm) than the LF group (6 mm). Proximal interphalangeal joint (PIP) stiffness was more common in the LF group, affecting one-third of patients. A cost analysis showed that ODs were 6.5 times less expensive than LFs performed in the operating theatre. OD appears to be a reliable and more cost-effective alternative to LF for treating zone 2 and 3 fingertip amputations with exposed bone, with similar healing time, better tactile discrimination and a lower rate of PIP joint stiffness. Level of evidence: IV
Machine Learning in Spine Oncology: A Narrative Review
Authors: Wilson Seth B. , Ward Jacob , Munjal Vikas , Lam Chi Shing Adrian , Patel Mayur , Zhang Ping , Xu David S. , Chakravarthy Vikram B. 
Published: June 2024

Study Design Narrative Review. Objective Machine learning (ML) is one of the latest advancements in artificial intelligence used in medicine and surgery with the potential to significantly impact the way physicians diagnose, prognose, and treat spine tumors. In the realm of spine oncology, ML is utilized to analyze and interpret medical imaging and classify tumors with incredible accuracy. The authors present a narrative review that specifically addresses the use of machine learning in spine oncology. Methods This study was conducted in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-Analysis (PRISMA) methodology. A systematic review of the literature in the PubMed, EMBASE, Web of Science, Scopus, and Cochrane Library databases since inception was performed to present all clinical studies with the search terms ‘[[Machine Learning] OR [Artificial Intelligence]] AND [[Spine Oncology] OR [Spine Cancer]]’. Data included studies that were extracted and included algorithms, training and test size, outcomes reported. Studies were separated based on the type of tumor investigated using the machine learning algorithms into primary, metastatic, both, and intradural. A minimum of 2 independent reviewers conducted the study appraisal, data abstraction, and quality assessments of the studies. Results Forty-five studies met inclusion criteria out of 480 references screened from the initial search results. Studies were grouped by metastatic, primary, and intradural tumors. The majority of ML studies relevant to spine oncology focused on utilizing a mixture of clinical and imaging features to risk stratify mortality and frailty. Overall, these studies showed that ML is a helpful tool in tumor detection, differentiation, segmentation, predicting survival, predicting readmission rates of patients with either primary, metastatic, or intradural spine tumors. Conclusion Specialized neural networks and deep learning algorithms have shown to be highly effective at predicting malignant probability and aid in diagnosis. ML algorithms can predict the risk of tumor recurrence or progression based on imaging and clinical features. Additionally, ML can optimize treatment planning, such as predicting radiotherapy dose distribution to the tumor and surrounding normal tissue or in surgical resection planning. It has the potential to significantly enhance the accuracy and efficiency of health care delivery, leading to improved patient outcomes.