bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operate for the Harmony: The Relationship Between Emerging Technologies and Legal System
Authors: Fan Zhuohao 
Published: February 2025

ABSTRACTThe innovation of emerging technologies has raised more demands on the law. In order to explore the relationship between emerging technologies and the legal system, this paper is based on Luhmann's systems theory, considering emerging technologies as products of scientific system. It constructs a static structural relationship between ‘scientific systems–social environment–legal systems.’ Additionally, it incorporates Prigogine's dissipative structure theory, supplementing the dynamic interaction process of energy among the three by redefining fluctuations and entropy values. There are actually two types of relationships between emerging technologies and the legal system: direct and indirect. The direct relationship involves the social environment as an intermediary. Emerging technologies participate in the operation of the legal system through social response, being outputted to the social environment. It forms the total energy of the environmental input system together with social expectations and then participates in the operation after being filtered by the screening diaphragm within the legal system. The indirect relationship operates through the structural coupling between the two systems. Emerging technologies themselves, as self‐referential entities within the legal system, participate in the operation. They indirectly influence the operation of the legal system through the entropy of their own operation in the scientific system.
Assessing the clinical meaningfulness of slowing CDR‐SB progression with disease‐modifying therapies for Alzheimer's disease
Authors: Hartz Sarah M. , Schindler Suzanne E. , Streitz Marissa L. , Moulder Krista L. , Mozersky Jessica , Wang Guoqiao , Xiong Chengjie , Morris John C. 
Published: February 2025

AbstractINTRODUCTIONFor many patients and caregivers, a major goal of disease‐modifying treatments (DMTs) for Alzheimer's disease (AD) dementia is to extend independence in instrumental and basic activities of daily living (IADLs and BADLs). The goal of this study was to estimate the effect of treatments on the time remaining independent in IADLs and BADLs.METHODSParticipants at the Knight Alzheimer Disease Research Center (Knight ADRC) who met eligibility criteria for recent DMT trials were studied: age ≥60 years at baseline, clinical diagnosis of very mild or mild AD dementia (global Clinical Dementia Rating [CDR] score 0.5 or 1), biomarker confirmation of amyloid pathology, and at least one follow‐up CDR assessment within 5 years. For IADLs, a subset of the Functional Assessment Questionnaire (FAQ) was examined that rated the degree of independence in the following: paying bills, driving, remembering medications and appointments, and preparing meals. For BADLs, the Personal Care domain of the CDR was used. Mixed‐effects logistic and ordinal regression models were used to examine the relationship between CDR Sum of Boxes (CDR‐SB) and the individual functional outcomes and their components. The change in CDR‐SB over time was estimated with linear mixed‐effects models.RESULTSA total of 282 participants were followed for an average of 2.9 years (standard deviation [SD] 1.3 years). For 50% of individuals, loss of independence in IADLs occurred at CDR‐SB >4.5 and in BADLs at CDR‐SB >11.5. For individuals with a baseline CDR‐SB = 2, treatment with lecanemab would extend independence in IADLs for 10 months (95% confidence interval [CI] 4–18 months) and treatment with donanemab in the low/medium tau group would extend independence in IADLs by 13 months (95% CI 6–24 months).DISCUSSIONIndependence in ADLs can be related to CDR‐SB and used to demonstrate the effect of AD treatments in extending the time of independent function, a meaningful outcome for patients and their families.Highlights
We estimated time to loss of independence for people with AD dementia
Estimating time to loss of independence can help with clinical decision‐making
Disease‐modifying treatments for AD dementia can extend independence
Video Killed the Radio Star—A Meta‐Analysis on Video‐Based Coaching to Improve Surgical Skill
Authors: Anderson Steven Mark , Gillanders Sarahlouise , Hickey Anne , Offiah Gozie , Davis Niall 
Published: February 2025

ABSTRACTBackgroundThe surgical trainee of today completes their postgraduate training with significantly less exposure than their mentors. The enforced reduced working hours, along with other factors, have created a gap in surgical training. Video‐based coaching (VBC) provides an opportunity to improve the surgical technical skill without needing to increase surgical volume. The aim on this study is to investigate the effect of VBC on the surgical technical skill.MethodsA systematic review of randomized controlled trials was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Bias was assessed for using The Cochrane Collaboration's tool for assessing risk of bias. The study was prospectively registered in the Open Science Framework (https://osf.io/sp8rb). Multiple subgroup analyses and meta‐analyses were carried out, with results reported as standardized mean differences (SMDs) in performance scores and presented as forest plots.ResultsA total of 15 studies comprising 382 participants were included in the final analysis. From these 15 studies, 201 participants received VBC following a range of surgical procedures. On meta‐analyses, the average performance scores for VBC were significantly higher than the controls (SMD 0.71, 95% CI 0.37, 1.04, Z = 4.15, and p < 0.0001) as were the average change scores from baseline to final performance (SMD 0.98 [95% CI 0.61, 1.35, Z = 5.19, and p < 0.0001]). Furthermore, the overwhelming majority of VBC participants across the studies found VBC to a be useful training tool.ConclusionsThis review represents the most comprehensive assessment of the impact of VBC in surgery and demonstrates it to be an effective training tool in improving surgical technical skill acquisition. Training bodies around the world should now look at how best to formally integrate VBC into conventional surgical training.
Local Decay Estimates
Authors: Soffer Avy , Wu Xiaoxu 
Published: February 2025

Abstract
We give a proof of local decay estimates for Schrödinger-type equations, which is based on the knowledge of Asymptotic Completeness. This approach extends to time dependent potential perturbations, as it does not rely on Resolvent Estimates or related methods. Global in time Strichartz estimates follow for quasi-periodic time-dependent potentials from our results.
HS-SPME–GC–MS analysis and consumer acceptance of blackcurrant juices made with innovative and conventional dejuicing systems
Authors: Wagner Annette , Zimmermann Lisa , Nagypál Jelena , Kiene Florian , Schuessler Christoph , Tarasov Andrii , Jung Rainer , Will Frank , Schweiggert Ralf , Steingass Christof Björn 
Published: February 2025

Abstract
Due to their importance for sensory perception, volatiles of blackcurrant (Ribes nigrum L.) juices obtained using three pressing systems in two subsequent years were assessed by HS-SPME–GC–MS. The 35 volatiles assigned comprised 15 terpenes, 10 terpenoids, six esters, two aldehydes and each one alcohol and norterpenoid. The aroma impact compound 4-methoxy-2-methyl-2-butanethiol (4MMB) was additionally quantitated by GC–SIM-MS after derivatization and solid phase extraction. Spiral filter press processing under exclusion of oxygen resulted in higher total concentrations of volatiles in the juices (3022 and 4865 μg/100 mL in 2019 and 2020, respectively) compared to those obtained using the conventional systems horizontal filter press and decanter (860–2122 μg/100 mL). Multivariate statistics permitted the clustering of the samples according to both, the pressing systems and year of processing and to deduce tentative marker compounds mostly contributing to their differentiation. Spiral filter pressed juices stood out for elevated levels of especially oxidation-sensitive terpenes. Levels of 4MMB ranged between 3.6 and 4.8 ng/100 mL among all samples. However, descriptive sensory analyses (n = 15 trained panelists) found only insignificant differences among the descriptor intensities comparing blackcurrant juices and nectars produced thereof for sensory analyses, each produced with the aforementioned three technologies. By contrast, consumer acceptance and preference tests (n = 51 consumers) showed a significant preference of the decanter made juice and the nectar derived thereof, accompanied by low ratings for the spiral filter pressed juices.
Assessment of chemical composition and in vitro and in silico anticarcinogenic activity of bee bread samples from Eastern Anatolia (Kars)
Authors: Gülbaz Güven , Akbaba Giray Buğra , Öztürkkan Füreya Elif 
Published: February 2025

Abstract
In this study, aqueous extracts of bee bread samples collected from five different regions in Eastern Anatolia (Kars, Turkey) were obtained by ultrasonic wave-assisted extraction method. Moisture, ash, acidity and pH values of bee bread samples were measured. Phenolic components of aqueous extracts were determined by LC-HRMS method. The cytotoxicity of these extracts on colon (DLD-1), breast (MCF-7), cervix (HeLa) and prostate cancer (PC-3) cells was determined by the MTT method. The interactions of genistein, naringenin and vitamin C, which are major components of the extracts, with important cancer targets such as human thymidylate synthase, c-MYC transcription factor, cyclin-dependent kinase and androgen receptor prostate cancer targets were investigated by Molecular Docking method. According to the findings, all extracts caused higher cytotoxicity on MCF-7 cancer cells compared to other cell lines, while they caused low cytotoxicity on PC-3 cells. Molecular Docking results show that the naringenin compound, whose anticarcinogenic effects have been supported by previous studies, may be a successful agent in inhibiting the active sites of selected cancer cell targets. When all these results are evaluated, it is recommended that the antitumoral effect of bee bread for the treatment of cancer disease be supported by further studies.
Convergence of the Stochastic Navier–Stokes-$$\alpha $$ Solutions Toward the Stochastic Navier–Stokes Solutions
Authors: Doghman Jad , Goudenège Ludovic 
Published: February 2025

Abstract
Loosely speaking, the Navier–Stokes-

$$\alpha $$

α

model and the Navier–Stokes equations differ by a spatial filtration parametrized by a scale denoted

$$\alpha $$

α

. Starting from a strong two-dimensional solution to the Navier–Stokes-

$$\alpha $$

α

model driven by a multiplicative noise, we demonstrate that it generates a strong solution to the stochastic Navier–Stokes equations under the condition

$$\alpha \rightarrow 0$$

α
→
0

. The initially introduced probability space and the Wiener process are maintained throughout the investigation, thanks to a local monotonicity property that abolishes the use of Skorokhod’s theorem. High spatial regularity a priori estimates for the fluid velocity vector field are carried out within periodic boundary conditions.
Associations between female sex hormones, estrous cycle, ischemic preconditioning and myocardial infarct size after ischemia–reperfusion injury
Authors: Pylova Tetiana , Elmahdy Ahmed , Krasnikova Maryna , Jha Abhishek , Andersson Erik Axel , Kakaei Yalda , Shekka Espinosa Aaron , Al-Awar Amin , Zulfaj Ermir , Nejat Amirali , Sevastianova Valentyna , Kalani Mana , Ryberg Henrik , Tivesten Åsa , Omerovic Elmir , Redfors Björn 
Published: February 2025

Abstract
Studies on sex differences in myocardial infarction (MI) typically focus on males versus females, the exploration of hormonal physiologic variations and their impact on the infarct size remains limited. The objective of this study was to examine whether infarct size after myocardial ischemia/reperfusion injury in female rats differs in different phases of the estrous cycle, and according to the levels of sex hormones; and to assess whether the effect of ischemic preconditioning on infarct size varies in different phases of the estrous cycle and between sexes. Female rats were divided into three groups based on the estrous cycle: proestrus, estrus, and diestrus. A fourth group consisted of ovariectomized female rats. Male rats were included as a fifth group, and orchiectomized males as a sixth group. Each group underwent ischemia/reperfusion injury, with or without prior ischemic preconditioning (IPC). Plasma sex hormone levels were measured with gas chromatography-tandem mass spectrometry. Females in the proestrus showed significantly smaller infarct size compared to all other groups. Multivariable analyses identified proestrus, IPC, and estradiol as independent predictors of smaller infarct size while male sex and gonadectomy as independent predictors of larger infarct size. There was a statistical interaction between IPC and both sex and hormonal status, with a greater protective effect of IPC on infarct size in males and gonadectomized rats. After ischemia–reperfusion, proestrus female rats developed the smallest while male and gonadectomized rats the largest infarct size. Conversely, IPC conferred greater cardioprotection in male and gonadectomized rats than females in proestrus.
Isolated Kalman filtering: theory and decoupled estimator design
Authors: Jung Roland , Luft Lukas , Weiss Stephan 
Published: February 2025

Abstract
In this paper, we propose a state decoupling strategy for Kalman filtering problems, when the dynamics of individual estimates are decoupled and their outputs are sparsely coupled. The algorithm is termed Isolated Kalman Filtering (IsoKF) and exploits the sparsity in the output coupling by applying approximations that mitigate the need for non-involved estimates. We prove that the approximations made during the isolated coupling of estimates are based on an implicit maximum determinant completion of the incomplete a priori covariance matrix. The steady state behavior is studied on eleven different observation graphs and a buffering scheme to support delayed (i.e. out-of-order) measurements is proposed. We discussed handling of delayed measurements in both, an optimal or a suboptimal way. The credibility of the isolated estimates are evaluated on a linear and nonlinear toy example in Monte Carlo simulations. The presented paradigm is made available online to the community within a generic C++ estimation framework supporting both, modular sensor fusion and collaborative state estimation.
Dynamics of pesticide residues in soils during the growing season: a case study in peach orchards, east-central Portugal
Authors: Veloso Abel , Silva Vera , Osman Rima , Simões Maria Paula , do Carmo Horta Maria , Geissen Violette 
Published: February 2025

Abstract
Permanent crops rely heavily on pesticides. Their short-term behaviour has already been characterised under laboratory conditions. However, their degradation in the field is still poorly understood. Furthermore, studies that relate pesticide residues in soil with their application history are still scarce, despite their relevance for inferring the historical and diffuse dimensions of pollution. This work explores the spatial and temporal dynamics of pesticide residues in soil under the light of their application records and the accuracy of the predicted environmental concentrations (PEC). To achieve these purposes, 270 soil samples were collected at 5 sampling times over the 2022 growing season, in 18 peach orchards from east-central Portugal. Moreover, the data extracted from the application records was used to obtain predicted levels which were compared with the measured results. A total of 37 residues were analysed. Overall, 32 of these were detected back in, at least, one sample. Glyphosate and AMPA were the most frequently found and had the highest median concentrations. The comparison between predicted and measured environmental concentrations (MEC) suggests that pesticide decay was generally slower than expected. Glyphosate, AMPA, fluopyram and tebuconazole showed a high potential for resulting in background concentrations in soil. Our results highlight the need for regular and comprehensive monitoring, being recommended long-term assessments of the persistence and fate of pesticides under realistic conditions. Furthermore, our results also stress the necessity of more studies on reasons for PEC-MEC mismatch, a factor of concern considering the regulatory relevance of PEC values.
Influence of feeding time on daily rhythms of locomotor activity, clock genes, and epigenetic mechanisms in the liver and hypothalamus of the European sea bass (Dicentrarchus labrax)
Authors: Samorì Elisa , Rodríguez Inmaculada , Oliver José Antonio , Sánchez-Vázquez Francisco Javier , López-Olmeda José Fernando 
Published: February 2025

Abstract
The circadian system plays a crucial role in most physiological processes. The molecular clock is linked to epigenetic mechanisms, both of which are influenced by nutrient status and, consequently, to feeding. This research investigated how feeding times (mid-light, ML, vs. mid-dark, MD) synchronize daily rhythms of behavior, clock genes, and epigenetic mechanisms in the European sea bass (Dicentrarchus labrax), focusing on hypothalamus and liver to assess the impact on central and peripheral pacemakers. Feeding at MD influenced the molecular clock of the hypothalamus, causing shifts in acrophases (peaks) for genes of the negative loop (per1b, per2, cry1a). In the liver, the ML fed group showed rhythmic expression for all clock genes, whereas only per2 maintained the rhythms in the MD group. Epigenetic genes related to methylation (dnmt1, dnmt3a) and demethylation (tet2, gadd45aa, mbd4) in the liver displayed rhythmic expression in the ML group, but only dnmt3a maintained the rhythm in the MD group. Nutrient-related factors (SAM and SAH) showed differences between day and night, suggesting a different utilization based on feeding times. Finally, sirt1, a gene involved in deacetylation, displayed a clear daily rhythm in the ML group. All epigenetic genes peaked during the night (resting phase). Overall, these findings indicated feeding time serves as a potent zeitgeber, synchronizing circadian clock and epigenetic rhythms in the liver, with peaks during the resting phase, suggesting this phase represents the adequate time for epigenetic modifications.
Tricuspid regurgitation after heart transplantation: where innovation and intervention are in hibernation
Authors: Alyaydin Emyal , Gotschy Alexander , Parianos Danaë , Nägele Matthias P. , Tudorache Igor , Flammer Andreas J. , Stehli Julia 
Published: February 2025

Abstract
Tricuspid regurgitation (TR) is a common valvular dysfunction following heart transplantation (HT), with reported prevalence rates ranging from 19 to 84%, primarily depending on the duration of follow-up. Its etiology is multifactorial and includes surgical technique, ischemic time, primary graft dysfunction, pulmonary hypertension, pacemaker leads, and endomyocardial biopsies. Severe TR can significantly impair graft function, exercise capacity, and patient survival. This mini-review explores current management strategies, including surgical techniques such as annuloplasty and tricuspid valve replacement. HT patients are often high-risk surgical candidates due to factors such as immunosuppressive therapy, prior surgeries, and various comorbidities. Therefore, we primarily focus on the evidence regarding emerging interventional methods, such as transcatheter edge-to-edge repair. Although these interventions show promising early results, they remain relatively novel in HT recipients, and the current evidence is based on case reports and small studies. Further research is essential to evaluate the long-term efficacy and safety of these management strategies to enhance outcomes for HT recipients with TR.

Graphical Abstract
Cloud-based semi-quantum money
Authors: Zhang Yichi , Jin Siyuan , Huang Yuhan , Zeng Bei , Shao Qiming 
Published: February 2025

Abstract
In the 1970s, Wiesner introduced the concept of quantum money, where quantum states serve as currency, offering physical-level unforgeability through quantum mechanics. Yet, traditional proposals often unrealistically assume personal quantum computing access for each user. To address these issues, we propose a cloud-based semi-quantum money (CSQM) scheme. This approach only requires semi-honest third-party quantum clouds, while the rest of the system, including transactions and banks, remains fully classical. We also estimate the computational power required by the quantum cloud and provide a thorough security analysis. Our approach significantly reduces the quantum resource demands on local users and facilitates seamless integration with current classical systems.
Reading subtyping of Arabic-speaking university students: a contribution to the accuracy vs. rate model of dyslexia
Authors: Tarabya Bahaa Madi , Andria Samer , Khateb Asaid 
Published: February 2025

Abstract
The current study sought to examine the existence of reading subtypes based on specific accuracy and rate criteria in dyslexia among a non-clinical sample of 120 Arabic-speaking University students and to characterize their reading-related and linguistic skills. For this aim, we relied on a conventional practice in reading disability literature based on a 25th percentile low achievement cut-offs. All students were examined using a battery of reading, linguistic, and cognitive tasks. The analysis conducted here provided partial support for the validity of the subtyping approach based on the accuracy and rate achievements and showed that ~ 12.5% of the sample could be defined as low accuracy (LA), ~ 10.8% as low rate (LR), and ~ 10.8% as a combined doubly low subtype (DL). The results showed that the combined DL group exhibited the lowest scores in all reading-related and linguistic tasks. Also, specific response patterns were found for LA and LR subtypes in reading-related pseudowords’ decoding and phonological awareness measures. These findings, the first to provide insights into the question of adult dyslexia through analysis of reading subtypes among Arabic-speaking students, are discussed in relation to previous findings in the literature among speakers of other languages. The data presented here provide new support for the adequacy of the accuracy vs. rate model of dyslexia among adults and stress the need for developing different interventions for the different reading subtypes.