bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation of hemodynamic flow patterns caused by aortic stenosis using a combined 4D Flow MRI-CFD framework
Authors: Wang Tianai , Quast Christine , Bönner Florian , Kelm Malte , Zeus Tobias , Lemainque Teresa , Steinseifer Ulrich , Neidlin Michael 
Published: June 2024

Abstract

Purpose
Aortic stenosis (AS) leads to alterations of supra-valvular flow patterns. These patterns might lead to, inter alia, an increased damage of red blood cell (RBC) membranes. The aim of this work was to elucidate these patient-specific patterns between a healthy subject and a patient suffering from severe AS through a 4D Flow MRI-based CFD methodology.
Material and methods
Computational models of subject-specific aortic geometries were created using in-vivo medical imaging data. Temporally and spatially resolved boundary conditions derived from 4D Flow MRI were implemented. After validation of the in-silico results with in-vivo data, the numerical flow fields were investigated regarding their blood flow characteristics, i.e. shear stresses on RBCs and helicity. These insights were used to determine the potential RBC damage in AS.
Results
The accuracy of the 4D Flow MRI-based CFD model was proven with excellent agreement between in-vivo and in-silico velocity fields and R² = 0.9. A pathological high shear stress region in the bulk flow was present during late systole with an increase of 125% compared to the healthy flow. The physiological bihelical structure with predominantly right-handed helices vanished for the pathological state. Instead, a left-handed helix appeared, accompanied by an overall increase in turbulent kinetic energy in areas of accumulated left-handed helicity. These alterations could cause RBC damage.
Conclusion
Validated 4D Flow MRI-based CFD models of healthy and AS patients suggest that altered turbulent and helical structures in the bulk flow are the cause for increased, potentially damaging forces acting upon RBCs in AS.
Case Report: Longitudinal Evaluation and Treatment of a Melanoma-Associated Retinopathy Patient
Authors: Mosavi-Hecht Ryan , Yang Paul , Heyer Barrett , Rosenberg Christopher R. , White Elizabeth , Berry Elizabeth G. , Duvoisin Robert M. , Morgans Catherine W. 
Published: June 2024

Abstract

Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome associated with cutaneous metastatic melanoma in which patients develop vision deficits that include reduced night vision, poor contrast sensitivity, and photopsia. MAR is caused by autoantibodies targeting TRPM1, an ion channel found in melanocytes and retinal ON-bipolar cells (ON-BCs). The visual symptoms arise when TRPM1 autoantibodies enter ON-BCs and block the function of TRPM1, thus detection of TRPM1 autoantibodies in patient serum is a key criterion in diagnosing MAR. Electroretinograms are used to measure the impact of TRPM1 autoantibodies on ON-BC function and represent another important diagnostic tool for MAR. To date, MAR case reports have included one or both diagnostic components, but only for a single time point in the course of a patient’s disease. Here, we report a case of MAR supported by longitudinal analysis of serum autoantibody detection, visual function, ocular inflammation, vascular integrity, and response to slow-release intraocular corticosteroids. Integrating these data with the patient’s oncological and ophthalmological records reveals novel insights regarding MAR pathogenesis, progression, and treatment, which may inform new research and expand our collective understanding of the disease. In brief, we find TRPM1 autoantibodies can disrupt vision even when serum levels are barely detectable by western blot and immunohistochemistry; intraocular dexamethasone treatment alleviates MAR visual symptoms despite high levels of circulating TRPM1 autoantibodies, implicating antibody access to the retina as a key factor in MAR pathogenesis. Elevated inflammatory cytokine levels in the patient’s eyes may be responsible for the observed damage to the blood-retinal barrier and subsequent entry of autoantibodies into the retina.
A New Attention-Based a convolutional neural network-gated recurrent unit Model for Spatial-Temporal PM2.5 Prediction
Authors: Haghbayan Sara , Momeni Mehdi , Tashayo Behnam 
Published: June 2024

Abstract

Accurately predicting the spatiotemporal distribution of PM2.5 using real data is a challenge, as missing data must be imputed and a suitable modeling method selected. When imputing missing data, the relationships between the variables must be taken into account while preserving their inherent variability and uncertainty. In this study, the imputation of missing data considering the relationships between meteorological variables and other pollutants was performed using different machine learning methods. After handling the missing data, the selection of an appropriate modeling method becomes imperative. In this paper, we attempt to present an innovative spatiotemporal hybrid model based on GRU that aims to obtain and extract spatiotemporal relationships. A dataset collected from 2017 to 2023 in Tehran metropolis was used for the study. The proposed model with (R2 = 0.84) can well determine the changes in PM2.5 concentration for each station and visualize the level of air pollution on a diffusion map.
Study of risk factors for sepsis among patients in the orthopedic department at Damascus Hospital
Authors: Alatrash Randa , Albouini Aseel , daher Nizar 
Published: June 2024

Abstract

Background: Surgical site infection (SSI) is one of the most important problems facing the orthopedic surgeon. Surgical site infection is an important prognostic factor that plays a major role in the progression of the case. This study was undertaken to evaluate the risk factors responsible for SSI and to determine the preventive measures for SSI.
Patients and Methods: This study compromised all the hospitalized patients in the Orthopedic Division in Tishreen University Hospital during 2018. This study analyzed 418 patients and studied the risk factors for the development of SSI and then categorized patients into two groups according to the development of infection (with and without).
Results: Infection has been developed in 42 patients (10%). In statistical analysis, we have found that open fractures were associated with infection (OR:10, 95% CI 4.8-20.9, p=0.0001), chronic kidney disease (OR:5.7, 95% CI 3.1-11.2, P=0.03), Internal fixation (OR:4.8, 95% CI 2.8-9.4, P=0.03), shaving in the patient room (OR:4.29, 95% CI 2.1-8.3, P=0.01), diabetes mellitus (OR:3.8, 95% CI 1.9-7.5, P=0.002), more than 2 hours surgery (OR:2.8, 95% CI 5.7-10.6, P=0.03), emergency stretcher (OR:2.4, 95% CI 1.2-4.6, P=0.02), Emergency Operating Room (OR:2.05, 95% CI 1.1-3.5, P=0.01), and lower limb (OR:2, 95% CI 1.1-3.2, P=0.04).
Conclusion: Open fractures, chronic kidney disease, Internal fixation, shaving in the patient room, diabetes mellitus, more than 2 hours’ surgery, emergency stretcher, Emergency Operating Room and lower limb each was an independent risk factor for the developing of SSI in the orthopedic division.
Wastewater surveillance of open drains for mapping the trajectory and succession of SARS-CoV-2 lineages in 23 class-I cities of Maharashtra State (India) during June 2022 to May 2023
Authors: Matra Sejal , Ghode Harshada , Rajput Vinay , Pramanik Rinka , Malik Vinita , Rathore Deepak , Kumar Shailendra , Kadam Pradnya , Tupekar Manisha , Kamble Sanjay , Dastager Syed , Bajaj Abhay , Qureshi Asifa , Kapley Atya , Karmodiya Krishanpal , Dharne Mahesh 
Published: June 2024

Abstract

The timely detection of SARS-CoV-2 is crucial for controlling its spread, especially in areas vulnerable to outbreaks. Leveraging Wastewater-Based Epidemiology (WBE), our study examined the proliferation, dissemination, and evolution of the virus across urban, suburban, and densely populated regions in Maharashtra state, India. Over the course of 12-months, from June 2022 to May 2023, SARS-CoV-2 RNA was consistently detected in wastewater samples collected from open drains across various regions of the state. Whole genome sequencing revealed the presence of 22 distinct SARS-CoV-2 lineages, with the Omicron variant dominating from July to September 2022, followed by the XBB variant from February to April 2023, along with other variants such as BF, BQ, CH, and BA.2.86, albeit with lower frequencies. Wastewater surveillance provided early insights into viral transmission, complementing clinical surveillance. Notably, our study detected emerging variants before clinical reporting, highlighting the potential of WBE for early detection. Our findings underscore the importance of WBE in tracking and managing the spread of COVID-19, especially in areas with limited clinical testing. This study highlights the significance of WBE in global infectious disease surveillance especially under low to middle-income countries (LMICs).
Manufacturer Encroachment with Consumer Digital Privacy
Authors: Li Hao , Lu Jizhou , Yan Nina , Lai Kin Keung 
Published: June 2024

Abstract

The rapid advancement of digital tools exacerbates privacy issues in the digital channel, despite providing enhanced media richness. This study distinguishes between consumers who prioritize privacy protection and those who prefer privacy disclosure, examining the impact of digital privacy on manufacturers’ channel strategy choices. Utilizing a game-theoretic model, we analyze manufacturers' decisions regarding the encroachment and retention of existing indirect channels. We explore three key strategies: no encroachment, encroachment, and shifting. Our findings indicate that when consumers favor privacy disclosure, manufacturers consistently opt for encroachment using the shifting strategy. Conversely, when consumers prioritize privacy protection, the optimal strategy for manufacturers varies according to the intensity of these preferences. Specifically, manufacturers tend to choose the encroachment strategy for weak preferences and the no-encroachment strategy for strong preferences. The potential for a win-win outcome between manufacturers and retailers is contingent upon the cost-efficiency of the manufacturer's channel construction. Furthermore, in scenarios where the manufacturer chooses to encroach, consumers consistently benefit. This study highlights the critical importance of assessing the type and degree of consumers' privacy preferences when establishing a direct-to-consumer digital channel. By understanding these nuances, firms can make informed decisions that maximize benefits for both themselves and consumers.
A Retrospective Analysis of Cases of Chronic Spontaneous Urticaria on Treatment with Oral Tofacitinib
Authors: Singh Rashmi , Kumar Rajnish , Bhaikhel Kamal Preet Kaur 
Published: June 2024

Background
The term chronic spontaneous urticaria (CSU) can be defined as urticaria lasting for more than 6 weeks with no established aetiology. Many newer molecules are being tried for managing the CSU cases not responding to conventional treatment as higher doses of antihistamines, oral steroids, oral methotrexate, oral cyclosporine, omalizumab, etc. One such oral agent is tofacitinib. Tofacitinib is known to inhibit the JAK -STAT pathway hence the release of many inflammatory cytokines and so target the pathophysiology of CSU and control symptoms of urticaria. Through this study, we have tried to bring out the efficacy and safety profile of this agent in resolving urticarial symptoms.

Methods
All cases of CSU who had not responded to higher recommended doses of anti-histamine (as per EACI guidelines) and on one or the other immunosuppressive agents were included in the study and based on baseline investigations and patients’ response to initial doses of tofacitinib and patient’s consent six patients were withdrawn from the study.

Results
Out of 15 patients of CSU included for final evaluation, 10 patients were completely cured of CSU at 6 months and 3 patients responded partially.

Conclusion
Tofacitinib is an innovative molecule for treating antihistamine non-responding cases of chronic spontaneous urticaria.
The Relationship between Quality of Work Life and Post-traumatic Stress Disorder in Nurses during the COVID-19 Pandemic: A Cross-sectional Study
Authors: Manzari Zahra Sadat , Mafi Mohammad Hossein , Nasiri Zahra Haji , Asgari Maryam , Ghaderi Mohammad Sajjad 
Published: June 2024

Introduction
In the midst of the global pandemic, nurses were confronted with numerous challenges that put them at risk of developing Post-Traumatic Stress Disorder. These challenges arise from the high mortality rates among patients and the diminished quality of life caused by overwhelming workloads.

Aim
The researchers conducted a study aimed at determining the relationship between the quality of work life and PTSD in nurses facing the healthcare crisis.

Methods
A cross-sectional study was conducted in Mashhad in 2021. The study sample consisted of 180 nurses working in hospitals admitting patients. The research instruments encompassed a demographic information form, the quality of work-life questionnaire with three sub-domains of compassion fatigue, burnout, and compassion satisfaction, and the post-traumatic stress disorder questionnaire. Data were analyzed using SPSS-25 software.

Results
Among the participating nurses, the mean and standard deviation of compassion fatigue, burnout, and compassion satisfaction scores in nurses were 24.16 ± 6.77, 25.26 ± 6.09, and 27.42 ± 6.51, respectively. Additionally, the mean score for stress following critical incidents was determined as 42.31 ± 8.71. Spearman's correlation test revealed a significant and positive relationship between the PTSD score and compassion fatigue within this sample.

Conclusion
The results indicated a positive correlation between the decrease in the quality of work life and PTSD. These findings contribute to a better understanding of effective strategies for promoting mental well-being and identifying key aspects to be measured in future interventions. Moreover, these results can guide the development of targeted mental health management interventions aimed at supporting nurses in their vital work during major health crises.
1827-LB: A Multilevel, mHealth-Based Culturally Tailored Diabetes Prevention Program for Chinese Immigrants—Preliminary Results from the INCLUDE Study
Authors: LIN NELSON , SHI YUN , YI STELLA S. , ANN SEVICK MARY , LI HUILIN , BEASLEY JEANNETTE , JIANG YULIN , ONG IRIS H. , BAI YUJIE , YANG XIMIN , SU LIWEN , HU LU 
Published: June 2024

Objective: Despite well-established evidence supporting the efficacy of the Diabetes Prevention Program (DPP), dissemination of the DPP to underserved communities is suboptimal. INCLUDE is an ADA-funded three year study to assess a multi-level mHealth intervention to provide a culturally tailored, language-concordant DPP and address food insecurity among Chinese immigrants. Here, we report feasibility data from Year 1 of the INCLUDE study.
Methods: INCLUDE is a randomized clinical trial with Chinese American adults with BMI ≥ 23 at risk for diabetes with a planned sample size of 150 and intervention duration of 3 months. In Year 1, 75 patients were randomized to intervention (n=38) or control (n=37) groups. Intervention participants received 2-3 culturally adapted in-language DPP videos a week for 12 weeks, biweekly calls from trained bilingual (Mandarin Chinese) study staff, and culturally appropriate produce weekly for 10 weeks at a local farm. The primary aim of the study is to evaluate weight loss at 3 and 6 months. This report presents feasibility data for intervention participants.
Results: Intervention participants (n=38, median age 48.5 [IQR 37.5-61.3]) were mostly female (84%), born outside the US (97%), and limited English proficient (82%). Participants reported an average video watch rate of 89% (SD 5.0%), a fresh produce pickup rate of 57% (SD 7.7%), a biweekly call completion rate of 81% (SD 15.5%). Overall retention rate was 95% at 3 months. Most (86%) participants agreed or strongly agreed that the program motivated weight loss, and all agreed or strongly agreed that the program increased confidence to prevent diabetes.
Conclusion: Initial results demonstrate feasibility of a culturally adapted multi-level DPP intervention for underserved Chinese immigrants. Additional research with a longer duration and larger sample size is warranted to examine intervention effectiveness with adequate power.

Disclosure
N. Lin: None. Y. Shi: None. M. Sevick: None. H. Li: None. J. Beasley: None. Y. Jiang: None. I.H. Ong: None. Y. Bai: None. X. Yang: None. L. Su: None. L. Hu: None.

Funding
American Diabetes Association (7-22-ICTSN-08)
Organization of the Detention of Prisoners of War of the German Army and Its Allies in the USSR (A Case Study of Cherepovets Camp no. 158)
Authors: Кузьминых А.Л. 
Published: June 2024

Предметом данной статьи является изучение практики содержания военнопленных германской армии и ее союзников в Череповецком лагере НКВД–МВД № 158. Особенностью данного лагеря было то, что он функционировал с 1942 по 1948 г., т.е. с начального периода Великой Отечественный войны до завершения репатриации основной массы военнопленных на родину. Это дает возможность, основываясь на историко-генетическом и историко-системном методах исследования, рассмотреть эволюцию политики советского государства по отношению к оказавшимся в его власти неприятельским военнослужащим и выявить механизмы ее реализации в отдельно взятом режимном учреждении. На основе анализа широкого комплекса источников автором проанализированы принципы внутреннего устройства лагеря и характеристики материально-бытового положения военнопленных, особенности медицинского обслуживания военнопленных; определена взаимосвязь между обеспечением военнопленных питанием, медицинской помощью, вещевым довольствием и их физическим состоянием, показателями заболеваемости и смертности; раскрыты содержание и динамика политико-пропагандистской работы среди военнопленных; показаны особенности репатриационного процесса.
The subject of this article is the study of the detention of prisoners of war of the German army and its allies in the Cherepovets NKVD–MVD Camp тo. 158. The specific feature of this camp was that it operated from 1942 to 1948, i.e. from the initial period of the Great Patriotic War until the completion of the repatriation of the majority of prisoners of war. That is why, the application of historical genetic and historical systemic methods, it is possible to consider the evolution of the policy of the Soviet state in relation to the enemy soldiers who found themselves at its mercy and to identify the mechanisms of its implementation in a single detention facility. Based on the analysis of a wide range of sources, the author considers the principles of the internal structure of the camp and the characteristics of the material and living situation of the prisoners of war detained there and the features of medical care for prisoners of war; the connection between the provision of prisoners of war with food, medical care, and clothing, on the one hand, and their physical condition, morbidity and mortality rates are determined; the content and dynamics of political propaganda among prisoners of war are revealed; the features of the repatriation process are shown.
EFEKTIFITAS INSTRUMEN MONETER SYARIAH TERHADAP PENYALURAN DANA KE SEKTOR USAHA MIKRO KECIL MENENGAH (UMKM) DI INDONESIA
Authors: Muhfiatun Muhfiatun , Syarifah Lailatis , Salam Annisa Nur 
Published: June 2024

Penelitian ini bertujuan untuk melihat sejauh mana instrumen moneter syariah bergerak mendorong perbankan syariah memberikan pembiayaan kepada sektor Usaha Mikro Kecil Menengah (UMKM) di Indonesia. Variabel dependen dalam penelitian ini adalah pembiayaan yang diberikan oleh perbankan syariah kepada sektor UKM/UMKM di Indonesia. Sedangkan variabel independen dalam penelitian ini yaitu instrumen moneter syariah: SBIS, SBSN, PUAS, Equivalent Rate Musyarakah, Equivalent Rate Mudharabah, dan Average Margin Murabahah. Menggunakan data sekunder berupa time series dari Januari 2010 sampai Desember 2018. Data yang digunakan adalah data bulanan bersumber dari Statistika Ekonomi dan Keuangan Indonesia pada Bank Indonesia (SEKI-BI), Statistik Perbankan Syariah Indonesia (SPSBI) dan Biro Pusat Statistik (BPS). Sedangkan teknis analisis data yang digunakan adalah Metode Vector Autoregression (VAR) atau Vector Error Correction Model (VECM). Hasilnya menunjukkan bahwa Instrumen Moneter Syariah seperti SBIS, SBSN, dan PUAS tidak efektif mendorong penyaluran dana ke sektor UMKM di Indonesia Keywords: Efektivitas, Instrumen Moneter Syariah, Penyaluran Dana, Sektor UMKM, VAR/VECM
ANALISIS SWOT FINANCIAL TECHNOLOGY (FINTECH) PERBANKAN SYARIAH DALAM OPTIMALISASI PENYALURAN PEMBIAYAAN DAN KUALITAS PELAYANAN BANK SYARIAH
Authors: Tiyan Lucky , Kurniawan Muhammad , Asriani Asriani , Syarif Hazas 
Published: June 2024

Penelitian ini bertujuan untuk melihat apakah penyaluran pembiayaan dan kualitas pelayanan berbasis Fintech telah optimal diimplementasikan oleh PT. Bank Mandiri Syariah KCP Kedaton Bandar Lampung dan PT. Bank BNI Syariah KC Tanjung Karang Bandar Lampung melalui metode analisis SWOT. Sampel dalam penelitian ini adalah pegawai pada dua Bank Syariah tersebut dan peneliti mengambil data dari penyebaran kuesioner untuk mengukur kondisi internal (kekuatan dan kelemahan) dan eksternal (peluang dan ancaman) serta melakukan wawancara dengan marketing finance untuk melihat implementasi pada penyaluran pembiayaan berbasis Fintech dan melakukan wawancara pada customer service untuk melihat implementasi pelayanan berbasis Fintech. Teknik analisis data yang digunakan adalah penghitungan manual dengan menggunakan pengukuran pada faktor internal (IFAS) dan eksternal (EFAS), kemudian dengan menghitung pada faktor internal-ekternal untuk mengetahui posisi kuadran SWOT Bank Syariah. Hasil analisis menunjukkan bahwa PT. Bank Mandiri Syariah KCP Kedaton Bandar Lampung dan PT. Bank BNI Syariah KC Tanjung Karang Bandar Lampung berada pada posisi kuadran 2 dimana ini berarti Bank Syariah harus menggunakan strategi diversifikasi. Kata kunci: Fintech, SWOT, Kuadran
ANALISIS SUSTAINABILITAS LEMBAGA KEUANGAN MIKRO SYARIAH DI KABUPATEN BANYUMAS
Authors: Ubaidillah Ubaidillah 
Published: June 2024

Sustainabilitas lembaga keuangan mikro syariah ini bermaksud untuk mengidentifikasi faktor-faktor yang menjadi penentu keberlanjutan Baitul Maal watTamwil (BMT) sebagai Lembaga Keuangan Mikro Syariah (LKMS). Kabupaten Banyumas dipilih menjadi objek penelitian didasarkan pada perkembangan BMT yang cukup baik di wilayah ini dan memiliki karakteristik yang menarik dan beragam dari segi permasalahan-permasalahan yang dihadapi, sehingga dimungkinkan untuk mendapatkan data-data yang dibutuhkan sesuai dengan permasalahan yang ada dalam penelitian ini. Kondisi di lapangan menunjukkan bahwa beberapa BMT berkembang pesat dan terus memperluas bisnisnya sementara beberapa BMT lain terancam bangkrut, merugi, dan tutup, tidak berjalan lagi sehingga mengancam keberlanjutan (sustainabilitas) dan perkembangan lembaga keuangan mikro syariah tersebut dalam jangka panjang.Penelitian ini menggunakan penelitian kuantitatif, subyek yang akan diteliti terletak pada masalah-masalah yang menjadi hambatan dalam pengelolaan Baitul maal wattamwil. Masalah-masalah tersebut diproksikan menjadiinternal dan eksternal. Masalah-masalah internal maupun eksternal tersebut meliputi kinerja lembaga yang belum optimal, kapasitas sumberdaya insani yang belum profesional, kinerja keuangan yang belum baik, permodalan yang lemah, dan infrastruktur yang kurang baik, regulasi yang tidak efektif dan pengawasan yang tidak maksimal. Faktor-faktor eksternal dan internal ini diolah menggunakan SPSS (Statistical Product and Service Solutions) 23. Kata kunci: Lembaga Keuangan Mikro Syariah (LKMS), Sustainabilitas, BMT.