bluuebunny/crossref_metadata_2025_split huggingface dataset:
Honoring the contract with our patients: outcome after repeated re‐transplantation of the liver
Authors: Eguchi Susumu , Soyama Akihiko , Mergental Hynek , van den Berg Aad P. , Scheenstra Rene , Porte Robert J. , Slooff Maarten J. H. 
Published: December 2010

Eguchi S, Soyama A, Mergental H, van den Berg AP, Scheenstra R, Porte RJ, Slooff MJH. Honoring the contract with our patients: outcome after repeated re‐transplantation of the liver.  Clin Transplant 2011: 25: E211–E218. © 2010 John Wiley & Sons A/S.Abstract:  The aim of this study was to describe the outcome after repeated orthotopic liver re‐transplantations (re‐OLT) in a population of adults and children, and to determine whether such repeated re‐transplantations are an effective treatment or should be considered futile. In a consecutive series of 867 patients, 628 adults and 239 children, who underwent OLT at the University Medical Center Groningen, 23 patients (2.7%), 10 adults and 13 children, underwent more than two re‐transplantations of the liver between March 1979 and October 2008. All 23 patients had a second re‐transplantation, and seven of them received a third transplant. The overall actuarial patient survival at 1, 5, and 10 yr after primary OLT was 96%, 87%, and 71%, respectively. The overall actuarial patient survival after the second re‐OLT was 78%, 73%, and 67%, respectively. Sixteen patients (70%) survived long term. However, for the 23 repeated re‐transplantation patients, 76 grafts were used. In a simulation calculation, it was shown that honoring the initial commitment to the 23 patients ultimately led to more surviving patients and less death than if treatment of the original patients was stopped after the first re‐transplantation and the remaining grafts were allocated to other primary graft recipients.
Ischemic preconditioning of the graft for intestinal transplantation in rats
Authors: Wang Zhe , Hernandez Francisco , Pederiva Federica , Andrés Ane M. , Leal Nuria , Burgos Emilio , Martínez Maria P. , Molina Manuel , Santamaría Manuel López , Tovar Juan A. 
Published: December 2010

Wang Z, Hernandez F, Pederiva F, Andrés AM, Leal N, Burgos E, Martínez MP, Molina M, Santamaría ML, Tovar JA. Ischemic preconditioning of the graft for intestinal transplantation in rats. Pediatr Transplantation 2011: 15:65–69. © 2010 John Wiley & Sons A/S.Abstract:  To test the hypothesis that two modalities of IPC should decrease acute rejection and BT after SBTx in rats. Orthotopic allogenic SBTx was performed from Wistar to BN. IPC was performed by 2 ′ and 5 ′ superior mesenteric artery clamping, following 2‐min and 5‐min reperfusion before graft cooling and retrieving. Donor–recipient sets were randomly allocated to five groups: IPC2m4d, IPC2m7d, IPC5min7d, and the control groups for the two end points; ctrl4d and ctrl7d. IRI, rejection, and BT were assessed after four or seven days depending on the groups. Measured variables included: histology, leukocyte activation by tissue MPO determination, and proinflammatory cytokines (IL‐b and TNF‐α) to assess inflammatory response. Leukocyte activation was significantly reduced in IPC2m7d in comparison with Ctrl and IPC5min7d. Rejection tended to be lower in IPC2min7d. Cytokine levels were contradictory and not consistent with histology. Finally, BT was less frequent in IPC2min4d group but this benefice was missed in animals with rejection (7d). Inflammatory response (MPO) was reduced and rejection tended to be lower after in IPC2m7d. Bacterial translocation was reduced in IPC2min4d but the benefice was missed at day 7.
Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient
Authors: Narayan Shoba , Tsai Eileen W. , Zhang Qiuheng , Wallace William D. , Reed Elaine F. , Ettenger Robert B. 
Published: December 2010

Narayan S, Tsai EW, Zhang Q, Wallace WD, Reed EF, Ettenger RB. Acute rejection associated with donor‐specific anti‐MICA antibody in a highly sensitized pediatric renal transplant recipient. Pediatr Transplantation 2011: 15:E1–E7. © 2010 John Wiley & Sons A/S.Abstract:  Allograft rejection in HLA identical transplant recipients and in patients without detectable donor‐specific anti‐HLA antibodies has lead to the identification of non‐HLA antigens as targets of the alloimmune response. MICA antigen has been recognized as an important non‐HLA target in renal transplantation. Recent studies have shown that anti‐MICA antibodies are associated with acute renal allograft rejection and failure. Current cross match procedures using donor lymphocytes fail to detect MICA antibodies. Transplant candidates are not routinely tested for pre‐sensitization to MICA antigens nor are transplant donors typed for MICA alleles. Optimal classification and treatment of acute rejection associated with MICA antibody remains unknown. In this case report, we are the first to describe the clinical course and treatment of donor‐specific MICA antibody associated with both Banff type II A ACR and AMR in a highly sensitized pediatric renal re‐transplant recipient. This case also emphasizes the importance of pre‐transplant screening for donor‐specific MICA antibody especially in highly sensitized renal transplant patients.
The role of cytomegalovirus infection and disease in pediatric bone marrow transplant recipients in Mexico City in the context of viral drug resistance
Authors: Arellano‐Galindo José , Vázquez‐Meraz Eugenio , Jiménez‐Hernández Elva , Velazquez‐Guadarrama Norma , Mikeler Elfriede , Hamprecht Klaus , Jahn Gerhard , Acosta‐Vázquez Francisco , Emma Mendoza‐García , Bello‐González Abel 
Published: December 2010

Arellano‐Galindo J, Vázquez‐Meraz E, Jiménez‐Hernández E, Velazquez‐Guadarrama N, Mikeler E, Hamprecht K, Jahn G, Acosta‐Vázquez F, Emma M‐G, Bello‐González A. The role of cytomegalovirus infection and disease in pediatric bone marrow transplant recipients in Mexico City in the context of viral drug resistance. Pediatr Transplantation 2011: 15:103–111. © 2010 John Wiley & Sons A/S.Abstract:  We aimed to identify those pediatric patients undergoing ABMT with CMV EOD who developed GCV resistance. Forty‐seven patients were analyzed following ABMT. Prospective post‐transplant CMV monitoring was performed weekly for the detection of viral leukocyte DNAaemia, viral plasma DNAaemia, and viral DNAuria by PCR. Plasma DNAaemia was confirmed from whole blood by the detection of CMV pp67 late mRNA using NASBA technology. In the cases of persistence of viral DNA in plasma, and positive viral RNA detection in blood, CMV drug resistance screening by comprehensive PCR‐based RFLP and sequencing of the viral UL97 gene were performed retrospectively. Thirty of the 47 (63.82%) patients showed active CMV infection with 27/30 (74.4%) patients belonging to the D+R+ group and 25/30 with proven viral replication. In total, 2/30 (6.6%) children developed CMV pneumonia proven by immunohistochemistry. Screening of the viral UL97 gene revealed in one of these two cases (1/30, 3.3%) the simultaneous presence of two point mutations in codon 460 (M460V, M460I) conferring GCV resistance. The CMV seroprevalence (81%) and the incidence of active infection (63.8%) in Mexican children undergoing ABMT are very high.
Brain‐type natriuretic peptide correlates with right heart pressures in a cross section of pediatric heart transplant patients
Authors: Hall E. K. , Glatz Andrew C. , Quartermain Michael D. , Ravishankar Chitra , Kaufman Beth , Cohen Meryl S. , Hanna Brian D. , Goldberg David J. 
Published: December 2010

Hall EK, Glatz AC, Quartermain MD, Ravishankar C, Kaufman B, Cohen MS, Hanna BD, Goldberg DJ. Brain‐type natriuretic peptide correlates with right heart pressures in a cross section of pediatric heart transplant patients. Pediatr Transplantation 2011: 15:70–74. © 2010 John Wiley & Sons A/S.Abstract:  Serum brain‐type natriuretic peptide level (BNP) correlates with hemodynamic parameters measured during cardiac catheterization in adult patients with heart failure. We sought to describe the relationship of BNP with invasive hemodynamic measurements and cellular rejection in children following OHT. Children undergoing catheterization for OHT surveillance had simultaneous measurement of BNP. A total of 62 subjects were studied. The median BNP was 171 pg/mL (range 19–1130). There were significant positive correlations between BNP and mean PAP (R = 0.33, p = 0.009), RVSP (R = 0.25, p = 0.05), RVEDP (R = 0.29, p = 0.02), and mean RAP (R = 0.39, p = 0.002). Rejection grade varied from 0 to 3A (58 patients < ISHLT 3A and four patients ≥ ISHLT 3A). There was no significant difference in BNP based on cellular rejection grade. In a cohort of pediatric patients after heart transplantation, BNP correlates with direct measurements of right‐sided pressures, but not with other hemodynamic measurements, time from transplant or rejection grade. This suggests that BNP may have a complimentary role in the monitoring of children following heart transplantation.
Non‐adherence in adolescent transplant recipients: The role of uncertainty in health care providers
Authors: Aujoulat Isabelle , Deccache Alain , Charles Anne‐Sophie , Janssen Magda , Struyf Catherine , Pélicand Julie , Ciccarelli Olga , Dobbels Fabienne , Reding Raymond 
Published: December 2010

Aujoulat I, Deccache A, Charles A‐S, Janssen M, Struyf C, Pélicand J, Ciccarelli O, Dobbels F, Reding R. Non‐adherence in adolescent transplant recipients: The role of uncertainty in health care providers. Pediatr Transplantation 2011: 15:148–156. © 2010 John Wiley & Sons A/S.Abstract:  To optimize self‐management and adherence in adolescent patients, HCPs need to discuss not only medical and treatment‐related issues, but also general health and psychosocial concerns. Our study aimed to explore how the members of the paediatric team in our programme understand NA in adolescents, and how they define their own role regarding self‐management education. We used a sequential mixed methods design and conducted a qualitative observational and in‐depth interview study (n = 22) and a quantitative descriptive study through self‐administered questionnaires (n = 31). Our results show a discrepancy between the HCPs’ understanding of the complex psychosocial factors impacting on long‐term adherence, and their current limited practice of patient education. A number of uncertainties were found to explain the HCPs’ perceived difficulty to engage in comprehensive patient education activities: uncertainty regarding (i) the health status of transplant recipients; (ii) a shared operational definition of adherence and the cause of organ rejection in some cases; (iii) the extent to which adherence is a shared responsibility which involves the HCPs as patient educators; (iv) the long‐term impact of a LRD. To avoid the risk of conveying incongruent messages, multidisciplinary health care teams need to explicitly acknowledge and discuss the various areas of uncertainty, some of which are inherent to transplantation.
Interventional radiology for hepatic artery complications soon after living donor liver transplantation in a neonate
Authors: Wakiya T. , Sanada Y. , Mizuta K. , Egami S. , Hishikawa S. , Nakata M. , Hakamada K. , Yasuda Y. , Kawarasaki H. 
Published: December 2010

Wakiya T, Sanada Y, Mizuta K, Egami S, Hishikawa S, Nakata M, Hakamada K, Yasuda Y, Kawarasaki H. Interventional radiology for hepatic artery complications soon after living donor liver transplantation in a neonate.Abstract:  Early hepatic artery complications after liver transplantation in children, having undergone LDLT, can directly affect graft and recipient outcomes, making early diagnosis and treatment essential. In the past, laparotomy (thrombectomy or reanastomosis) was generally employed to treat early hepatic artery complications. Recently, favorable outcomes of IR have been reported. In children, however, the number of such reports is small. To the best of our knowledge, there is no published report on IR applied to neonates with early hepatic artery complications. We recently succeeded in safely using IR for a neonate with early hepatic artery complications after LDLT and obtained a favorable outcome. This case is presented herein.
Donor‐specific HLA antibodies in paediatric cardiac transplant recipients are associated with poor graft survival
Authors: Irving Claire , Carter Vaughan , Parry Gareth , Hasan Asif , Kirk Richard 
Published: December 2010

Irving C, Carter V, Parry G, Hasan A, Kirk R. Donor‐specific HLA antibodies in paediatric cardiac transplant recipients are associated with poor graft survival. Pediatr Transplantation 2011: 15:193–197. © 2010 John Wiley & Sons A/S.Abstract:  There is increasing evidence that DSA are associated with poor graft survival, although there are little data in children. We aimed to describe the incidence of DSA in this group and to determine correlation with graft survival. HLA antibodies were analysed in 59 paediatric cardiac transplant recipients. Mean age 10.4 (0.7–18.5) yr, mean time post‐transplant 5.1 (0.3–17.3) yr. Antibody detection/identification was performed on the Luminex platform with subsequent identification using Lifescreen Identification kits/One‐Lambda Single antigen kits. Forty patients (69%) had no HLA antibodies. DSA were found in four (7%). One had transient Class I antibodies and normal cardiac function. The other three had persistent Class II antibodies (two subsequently required re‐transplantation, the third had cardiac failure due to CAV). Non‐DSA were found in 15 (25%), all with normal graft function and without rejection. There was no difference in function or CAV prevalence between those with non‐DSA and those without antibodies. HLA DSA is uncommon in paediatric cardiac allograft recipients but, if persistent, suggests poorer prognosis. In our series, antibodies to HLA class II on donor tissue were associated with increased graft loss. Routine screening and regular testing are recommended.
The utility of comprehensive assessment of donor specific anti‐HLA antibodies in the clinical management of pediatric kidney transplant recipients
Authors: Gloor James M. 
Published: December 2010

Gloor JM. The utility of comprehensive assessment of donor specific anti‐HLA antibodies in the clinical management of pediatric kidney transplant recipients. Pediatr Transplantation 2011: 15: 557–563. © 2010 John Wiley & Sons A/S.Abstract:  Advances in anti‐HLA antibody characterization have had a major impact on kidney transplantation. Comprehensive characterization of DSA has improved protocols for allosensitized transplant candidates, increasing access to acceptable donors. Sensitive and specific solid phase antibody detection assays have given important insight into the clinical characteristics of antibody‐mediated allograft injury, resulting in the development of a classification system for acute AMR. In addition, important insights into the nature of chronic antibody‐mediated allograft rejection have been achieved as a result of improvements in DSA characterization. Finally, assays initially developed as tools to detect DSA in the clinical setting have been employed in innovative research protocols, allowing the investigation of new therapeutic approaches.
Application of the HALF index obviates the need for liver biopsy in half of all patients with chronic hepatitis B
Authors: Lee Hyun Jung , Seo Yeon Seok , Kim Dong Jin , Kang Hyun Seok , An Hyonggin , Kim Ji Hoon , Cheong Jae Youn , Yim Hyung Joon , Yeon Jong Eun , Lee Hong Sik , Byun Kwan Soo , Cho Sung Won , Kim Dong Joon , Um Soon Ho , Kim Chang Duck , Ryu Ho Sang 
Published: December 2010

AbstractBackground and Aims:  Transient elastography (TE) is useful for predicting the fibrosis stage, but it is unsatisfactory as a substitute for liver biopsy, especially in patients with chronic hepatitis B (CHB). This study was performed to establish a reliable model for predicting significant fibrosis (SF) in patients with CHB.Methods:  All CHB patients who were admitted to undergo liver biopsy were enrolled. They were randomly classified into either a training set (n = 139) or a validation set (n = 69). A model for predicting SF was established in the training set and validated in the validation set. Low and high cutoff values (COVs) were chosen for sensitivity ≥ 99% and specificity ≥ 99%, respectively.Results:  A total of 208 patients were enrolled. Age was 39 ± 12 years and 149 (71.6%) were men. In the training set, liver stiffness values and serum haptoglobin, apolipoprotein A1, and α2‐macroglobulin levels were independent predictors of SF on multivariate analysis. These variables were used to construct a novel model, called the HALF index. The area under the receiver operating characteristics curve of the HALF index for predicting SF was significantly higher than that of TE alone (0.915 vs 0.877, P = 0.010). Using low and high COVs of the HALF index, it appears that approximately half (47.1%) of patients could avoid liver biopsy, with an associated accuracy of 99.0%.Conclusion:  A combination of liver stiffness and serum markers identified SF with a high degree of accuracy. Approximately half of all patients with CHB could avoid liver biopsy through the utilization of the HALF index.
NSAIDs are a significant risk factor for colonic diverticular hemorrhage in elder patients: Evaluation by a case‐control study
Authors: Tsuruoka Nanae , Iwakiri Ryuichi , Hara Megumi , Shirahama Natsuko , Sakata Yasuhisa , Miyahara Koichi , Eguchi Yuichiro , Shimoda Ryo , Ogata Shinichi , Tsunada Seiji , Sakata Hiroyuki , Fujimoto Kazuma 
Published: December 2010

AbstractBackground and Aim:  Diverticular bleeding is a common cause of lower gastrointestinal hemorrhage. Several factors, including use of non‐steroidal anti‐inflammatory drugs (NSAIDs), antithrombotic agents and arteriosclerosis, could be risk factors. The aim of this study is to identify these risk factors.Methods:  Between January 2000 and December 2008, 51 patients among 178 acute lower gastrointestinal hemorrhages who visited Saga Medical School were diagnosed as colonic diverticular hemorrhage, established by emergency endoscopy and diagnostic criteria. Gender and age matched control cases were selected from patients of other diseases hospitalized during the same period. We evaluated by using logistic regression analysis the influences of comorbidities such as cerebrovascular disease, ischemic heart disease, hypertension, hyperlipidemia, diabetes mellitus, chronic kidney disease, and osteoporosis, medications including NSAIDs and antithrombotic agents, and habits of smoking, alcohol, and chronic constipation.Results:  Fifty one patients out of 178 acute lower gastrointestinal bleeding (28.7%) were diagnosed as diverticular hemorrhage, which was the most common cause of lower gastrointestinal hemorrhage. Sex ratio of men versus women for colonic diverticular hemorrhage was 35:16. NSAIDs were a significant risk factor for colonic diverticular hemorrhage in elder patients (odds ratio [OR] = 7.492, 95% CI: 1.516–37.024, P = 0.0135). Hypertension and hyperlipidemia had significant association with diverticular hemorrhage among patients younger than 65 years old. This study also indicated that use of NSAIDs was a risk factor for re‐bleeding (OR = 5.4, 95% CI: 1.01–28.78, P = 0.048).Conclusion:  This case‐control study revealed that the use of NSAIDs was a significant risk factor for colonic diverticular hemorrhage in elder patients. In addition, use of NSAIDs is a risk factor for re‐bleeding from colonic diverticula.
Extended indication of endoscopic resection for mucosal early gastric cancer: Analysis of a single center experience
Authors: Chung Jun‐Won , Jung Hwoon‐Yong , Choi Kee Don , Song Ho June , Lee Gin Hyug , Jang Se Jin , Park Young‐Su , Yook Jeong Hwan , Oh Sung Tae , Kim Byung‐Sik , Kim Jin‐Ho 
Published: December 2010

AbstractBackground:  Endoscopic resection (ER) has become an important therapeutic option for early gastric cancer (EGC). Some investigators have suggested that this indication should be extended. We aimed to compare the extended indication of ER for intramucosal EGC based on data from a large, single‐center study.Methods:  We assessed lymph node metastasis (LNM) status in 1721 intramucosal EGC patients who underwent surgery to evaluate the potential of extension of the ER. We investigated LNM according to Japanese extended criteria; differentiated mucosal cancers irrespective of ulcer less than 30 mm (Criteria I); differentiated mucosal cancers without ulceration irrespective of tumor size (Criteria II), undifferentiated less than 20 mm without ulceration (Criteria III). We also tried to find the groups which have no and minimal risk of lymph node metastasis.Results:  The rate of LNM of mucosal cancer was 2.6% (45/1721). There was minimal lymph nodal metastasis risk for criteria I (0.28%, 2/726, 95% Confidence Interval [CI], 0–0.66%), and criteria II (0.23%, 2/882, 95% CI, 0–0.54%). For criteria III, there was significant lymph node metastasis risk (1.15%, 3/261, 95% CI, 0–2.44%). There was no lymph node metastasis in differentiated mucosal cancer less than 20 mm irrespective of ulcer (0%, 0/501, 95% CI 0–0.73%). The differentiated mucosal cancer group irrespective of ulcer and tumor size have a minimal risk of metastasis (0.43%, 4/941, 95% CI, 0–0.84%)Conclusion:  Our data support extension of the ER indication for the differentiated mucosal EGC. However, undifferentiated lesions without ulceration and smaller than 20 mm were associated with significant metastasis.
Effects of wave energy on the residence times of a fluorescent tracer in the canopy of the intertidal marine macroalgae, Sargassum fusiforme (Phaeophyceae)
Authors: Nishihara Gregory N. , Terada Ryuta , Shimabukuro Hiromori 
Published: December 2010

SUMMARYWe determined the relationship between the residence times of water within the canopy of the intertidal macroalgae, Sargassum fusiforme (Harvey) Setchell to the energy caused by hydrodynamic mixing. We measured the residence times (t) of fluorescein dye injected into the canopy (31 ± 9 ind/quadrat; canopy plan form area 6 × 1 m2) to estimate the length of time gametes persist within the canopy. The total kinetic energy (TKE) and wave energy (WE) was measured during dye dispersal, which ranged from 0.002 to 0.009 m2/s2 and 0.001 to 0.016 m2/s2, respectively. The experiments revealed that the canopy significantly (P < 0.0001) increased t, which was 56 ± 35 s inside of the canopy compared with 14 ± 4 s outside. Moreover, the relationship between t and energy could be statistically modeled with a power function, and for the results inside of the canopy, t = 3.67 TKE−0.50 for turbulent kinetic energy and t = 1.83 WE−0.38 for wave energy. Outside of the canopy, t = 0.98 TKE−0.50 and t = 1.83 WE−0.38 Based on the values of t determined for within the canopy, we developed a dispersion model to explore how gametes dispersed within the canopy. The estimated dispersion coefficient (D) with respect to WE, could be modeled as D = 403 WE0.55 and ranged from 10 to 42 cm2/s for the WE examined in the study. Areal gamete densities modeled in the canopy increased in density for increasing WE at short (0.5 h) durations of gamete discharge; however, the relationship reversed above 2 h of discharge.