bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and characterization of poly[acrylamide‐co‐3‐(acryloylamino)propyldodecyldimethylammonium bromide]/polyoxometalate composite microspheres
Authors: Li Hong , Cui Xin'ai , Shen Shukun , Hu Daodao 
Published: April 2011

AbstractSurfmer [3‐(acryloylamino)propyl]dodecyldimethyl ammonium bromide (APDDAB) was synthesized and characterized. On the basis of the reverse emulsion polymerization technique, poly[acrylamide‐co‐3‐(acryloylamino)propyldodecyldimethylammonium bromide] [P(AM‐co‐APDDAB)] copolymer microgels were obtained with the copolymerization of acrylamide and APDDAB. The P(AM‐co‐APDDAB)/polyoxotungstates composite microspheres were prepared with the ion‐exchange reaction of the P(AM‐co‐APDDAB) microgels with phosphotungstic acid (H3PW12O40). The morphologies and components of the composite microspheres were characterized by scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, thermogravimetric analysis, and Fourier transform infrared spectroscopy. The results indicate that the P(AM‐co‐APDDAB)/PW12O40 composite microspheres all had a core–shell structure. For the composite microspheres, the hydrogel P(AM‐co‐APDDAB) was dominantly located in the core, and the complexes of PW12O403− with APDDAB were mainly located in the surface; these features made the composite microspheres amphiphilic and provided for potential catalysis in a two‐phase reaction. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
The mediastinal waltz – A representation of asymmetrical mediastinal anatomy
Authors: Chan Lap Ki 
Published: April 2011

AbstractThis article describes a representation formed by a waltzing couple of two students that can be used to teach the asymmetrical anatomical relationships among the trachea, bronchi, pulmonary trunk, and the pulmonary arteries in the mediastinum. Anat Sci Educ 4:174–175, 2011. © 2011 American Association of Anatomists.
Comparison of three separate antiadhesive barriers for intraperitoneal onlay mesh hernia repair in an experimental model (Br J Surg 2011; 98: 442–449)
Authors: Aellen S , Cotton M , Demartines N , Vuilleumier H 
Published: April 2011

Abstract
The Editors welcome topical correspondence from readers relating to articles published in the Journal. Responses should be sent electronically via the BJS website (www.bjs.co.uk). All letters will be reviewed and, if approved, appear on the website. A selection of these will be edited and published in the Journal. Letters must be no more than 250 words in length.
Integrated approach to produce a recombinant, his‐tagged human α‐galactosidase a in mammalian cells
Authors: Corchero José Luis , Mendoza Rosa , Lorenzo Julia , Rodríguez‐Sureda Victor , Domínguez Carmen , Vázquez Esther , Ferrer‐Miralles Neus , Villaverde Antonio 
Published: April 2011

AbstractSuccessful production of recombinant proteins (r‐proteins) by transient gene expression (TGE) depends on several parameters (including producer cells, culture conditions, transfection procedure, or expression vector) that should be optimized when producing any recombinant product. In this work, TGE‐based production of human α‐galactosidase A (GLA) is described. Producer cells, expression vectors, and parameters influencing cell metabolism after transfection have been tested. The enzyme is secreted, has the right molecular weight, and is enzymatically active. Productivities of up to 30–40 mg/L have been achieved, with a simple, fast procedure. A 6 × His tag allows enzyme purification in a single step, rendering a highly pure product. We propose a TGE‐based protocol able to produce up to several milligrams per liter of highly pure, active GLA in a time as short as a few days. By this, enough amounts of engineered versions of the enzyme can be easily produced to be tested in vitro or in preclinical trials. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Embolization of an amplatzer mVSD occluder device used for percutaneous closure of an ascending aortic pseudoaneurysm: Case report and literature review
Authors: Noble Stéphane , Ibrahim Réda 
Published: April 2011

AbstractPseudoaneurysm of the ascending aorta is a rare, but potentially dangerous condition. The high morbidity and mortality rate associated with its surgical management has led to the development of transcatheter approaches. We report a case of percutaneous closure of an ascending aortic pseudoaneurysm using an Amplatzer mVSD occluder device complicated by device embolization at day 27 and we review the literature of Amplatzer devices in this off‐label use. © 2011 Wiley Periodicals, Inc.
Endovascular treatment of mesenteric ischemia
Authors: Hawkins Beau M. , Khan Zeeshan , Abu‐Fadel Mazen S. , Exaire J. Emilio , Saucedo Jorge F. , Hennebry Thomas A. 
Published: April 2011

AbstractObjectives: Our goal was to describe a single‐center's experience in managing acute and chronic mesenteric ischemia with endovascular therapies.Background: Open surgical revascularization has been considered the historical gold standard treatment for mesenteric ischemia though it poses considerable morbidity and mortality risk. An aging population with increased comorbidities makes endovascular treatment a more attractive treatment option.Methods: Consecutive subjects receiving percutaneous mesenteric interventions for acute and chronic mesenteric ischemia from 2004 to 2010 were identified retrospectively. Information on comorbidities, symptoms, screening tests, procedural outcomes, and follow up was obtained.Results: Thirty‐one patients received percutaneous mesenteric interventions during this period. The mean age of the population was 65.0 years with roughly equal proportions of males (48.4%) and females (51.6%). Traditional cardiovascular risk factors were highly prevalent (hypertension 45.2%, diabetes 25.8%, dyslipidemia 38.7%, nicotine use 45.2%). Procedural success was 93.5%; no periprocedural complications were reported. During a mean follow up of 13 months, 16.1% required repeat revascularization and 22.6% died. Endovascular treatment of acute mesenteric ischemia was successful (n = 8) and no patient required open surgical revascularization acutely or during follow‐up.Conclusions: Endovascular treatment of mesenteric ischemia is a safe and effective therapy with acceptable long‐term results. Our experience with acute mesenteric ischemia suggests that percutaneous treatment may be an effective alternative to surgical revascularization in appropriately selected patients. © 2011 Wiley Periodicals, Inc.
Very late stent thrombosis due to DES fracture: Description of a case and review of potential causes
Authors: Lee Stephen W.L. , Tam Frankie C.C. , Chan Kelvin K.W. 
Published: April 2011

AbstractStent fracture and subsequent stent thrombosis are known complications after stent implantation, especially in stents with closed cell design like the first generation sirolimus drug eluting stents (DES). Late stent thrombosis is very rarely encountered in our patient population, majority Chinese. We report a case of non‐ST elevation myocardial infarction as a result of very late stent thrombosis (three years after implantation) due to stent fracture at the site of overlap of two first generation sirolimus DES. There were initial difficulties in restoring coronary flow by conventional reperfusion therapies but a successful outcome after implantation of an endothelial progenitor cell capture stent, with no further recurrence of ischemic event after 12 months. An attempt was made to analyze all existing factors present and contributing to the stent fracture and stent thrombosis in this case, as reported in the literature. © 2011 Wiley Periodicals, Inc.
Impella assisted transradial coronary intervention in patients with acute coronary syndromes and cardiogenic shock
Authors: Bell Brendan P. , Iqtidar Ali F. , Pyne Christopher T. 
Published: April 2011

AbstractOperators may feel apprehension when considering the transradial approach in patients with cardiogenic shock due to concerns of the need for femoral access for mechanical support. There is however potential benefit of transradial approach in this setting by reducing bleeding complications in patients on potent anticoagulant and antiplatelet agents. We report three cases of patients with cardiogenic shock with successful transradial intervention (TRI) whilst using unilateral femoral access for Impella (ABIOMED, Danvers, MA) mechanical support. In two cases, the need for mechanical support was not clear at the beginning of the procedure, and in the third there was a clear need to combine femoral and radial access due to pre‐existing anatomic issues. Two patients required transfusion of red blood cells but otherwise there were no vascular access complications. © 2011 Wiley Periodicals, Inc.
Intracoronary bolus‐only compared with intravenous bolus plus infusion of tirofiban application in patients with ST‐elevation myocardial infarction undergoing primary percutaneous coronary intervention
Authors: Kırma Cevat , Erkol Ayhan , Pala Selçuk , Oduncu Vecih , Dündar Cihan , İzgi Akın , Tigen Kürşat , Gibson C. Michael 
Published: April 2011

AbstractObjectives: The aim of this pilot study was to compare intracoronary bolus‐only with standard intravenous bolus plus maintenance infusion of tirofiban with respect to improvement in myocardial reperfusion after primary percutaneous coronary intervention (p‐PCI). Background: Changes in clinical practice may obviate the need for a maintenance infusion of small molecule glycoprotein IIb/IIIa inhibitors in current practice. Methods: Forty‐nine patients undergoing p‐PCI were randomized to either intracoronary bolus‐only (n = 25) or intravenous bolus plus infusion (n = 24) of tirofiban. The primary end point was coronary hemodynamic indices of microvascular perfusion measured 4–5 days after p‐PCI. The secondary end points were ST segment resolution at 90 min, the corrected TIMI frame count and myocardial blush grade. At 6 months, echocardiography and technetium‐99m single‐photon‐emission computed tomography were performed. Results: Microvascular perfusion did not differ significantly between the two treatment groups: index of microvascular resistance (27 ± 13 vs. 35 ± 15 U, P = 0.08) and coronary flow reserve (2.2 ± 0.7 vs. 1.9 ± 0.6, P = 0.25). The corrected TIMI frame counts assessed in the first (P = 0.13) and the second (P = 0.09) catheterization or the myocardial blush grades evaluated immediately (P = 0.23) and 4–5 days after MI (P = 1.00) were not significantly different between the two groups. At 6 months, there was no difference between the two groups in infarct size, left ventricular volumes, or ejection fraction. Conclusions: The standard intravenous bolus plus maintenance infusion of tirofiban in p‐PCI is not superior to intracoronary bolus‐only administration with respect to microvascular perfusion. Further, adequately powered randomized trials are warranted to evaluate the clinical outcomes associated with this strategy. © 2011 Wiley Periodicals, Inc.
Sustained clinical safety and efficacy of a biodegradable‐polymer coated sirolimus‐eluting stent in “real‐world” practice: Three‐year outcomes of the CREATE (multi‐center registry of EXCEL biodegradable polymer drug eluting stents) study
Authors: Han Yaling , Jing Quanmin , Li Yi , Yang Lixia , Liu Huiliang , Shang Xiaoming , Jiang Tiemin , Li Zhanquan , Zhang Hua , Yan Gaoliang ,   The Multi‐Center Registry of EXCEL BiodegrAdable Polymer Drug EluTing Stents (CREATE) investigators
Published: April 2011

AbstractBackground: The CREATE is a post‐marketing surveillance multicenter registry that demonstrated satisfactory angiographic and clinical (at 18 months) outcomes of a biodegradable polymer based sirolimus‐eluting stent (EXCEL, JW Medical System, Weihai, China) for the treatment of patients in routine clinical practice.Objectives: To evaluate the three‐year clinical safety and efficacy outcomes in patients enrolled in the CREATE study.Methods: A total of 2077 all comers have been enrolled in the CREATE study at 59 centers from four countries. Recommended antiplatelet regimen was clopidogrel and aspirin for six months followed by chronic aspirin therapy. The prespecified primary outcome was the rate of major adverse cardiac events (MACE) at 12, 18, and 36 months.Results: Clinical follow‐up was completed in 2025 (97.5%) patients at three years. The average duration of clopidogrel treatment was 199.8 ± 52.7 days and 80.5% of discharged patients discontinued clopidogrel at six months. The cumulative rate of MACE was 4.5% and the rate of stent thrombosis was 1.53% at three years. At six months to three years, prolonged clopidogrel therapy (>6 months) was not beneficial in reducing cumulative hazards of MACE (3.4% vs. 3.1%, log rank P = 0.725) or stent thrombosis (1.5% vs. 0.6%, log rank P = 0.053).Conclusions: This study demonstrates sustained three‐year clinical safety and efficacy of biodegradable polymer‐based sirolimus‐eluting stents when used with six months of dual antiplatelet therapy in a “real‐world” setting. © 2011 Wiley Periodicals, Inc.
Caking Behaviour of Spray‐Dried Powders – Using Scanning Probe Microscopy to Study Nanoscale Surface Properties and Material Composition
Authors: Prime D. C. , Leaper M. C. , Jones J. R. , Richardson D. J. , Rielly C. D. , Stapley A. G. F. 
Published: April 2011

AbstractSpray drying is widely used to manufacture many powdered products, with the drying process parameters having significant influence over the final powder's surface properties and propensity for unwanted caking. In most cases caking experiments are performed on bulk powders, but especially in multi‐component powders, it is often difficult to interpret these results, where interaction effects between particles can be complex. Here the technique of scanning probe microscopy is used to characterize the nanoscale properties of spray dried model milk powders in order to investigate the surface properties of the powders.
Prediction of the Behavior of a Liquid‐Fluidized Bed of Inert Particles Used for Separation by Density
Authors: Tatemoto Y. , Higashino T. , Suzuki Y. , Michikoshi T. , Maeda S. , Bando Y. 
Published: April 2011

AbstractA liquid‐fluidized bed of inert particles was used to separate a pure object from a mixture. One (binary solid‐liquid‐fluidized bed) or two (tertiary solid‐liquid‐fluidized bed) types of objects with relatively large‐sized particles were immersed in an inert‐particle bed, and the bed behavior was observed for different liquid velocities. The void fraction and apparent density of the inert‐particle suspension were predicted by considering the effect of the change in object position for different liquid velocities. The prediction method, which considers the change in the minimum fluidization velocity, accurately expressed the changes in the void fraction and the apparent density of the bed with the position of the objects in the bed. Using this method, the liquid velocity required to separate a certain kind of object from a mixture can be predicted.
Effects of Process Parameters on Gypsum Scale Formation in Pipes
Authors: Hoang T. A. , Ang M. , Rohl A. L. 
Published: April 2011

AbstractScaling often leads to a series of technical and economical problems in industrial plants and equipments by blocking water flow in pipes or limiting heat transfer in heat exchangers. While most contemporary studies are focusing on crystallization at heat‐exchanger surfaces and scaling on nanofilters in desalination plants, very little work has been done investigating scale formation on pipe and vessel walls. A comprehensive investigation of the effects of various process parameters in controlling the formation of calcium sulfate scale in pipes was undertaken. Supersaturation ratio, run time, and operational hydrodynamics were altered systematically to determine their influence on the scale growth rate. The results confirmed that the deposition of gypsum on pipe walls was significantly affected by these process parameters.
OnPLS—a novel multiblock method for the modelling of predictive and orthogonal variation
Authors: Löfstedt Tommy , Trygg Johan 
Published: April 2011

AbstractThis paper presents a new multiblock analysis method called OnPLS, a general extension of O2PLS to the multiblock case. The proposed method is equivalent to O2PLS in cases involving only two matrices, but generalises to cases involving more than two matrices without giving preference to any particular matrix: the method is fully symmetric. OnPLS extracts a minimal number of globally predictive components that exhibit maximal covariance and correlation. Furthermore, the method can be used to study orthogonal variation, i.e. local phenomena captured in the data that are specific to individual combinations of matrices or to individual matrices. The method's utility was demonstrated by its application to three synthetic data sets. It was shown that OnPLS affords a reduced number of globally predictive components and increased intercorrelations of scores, and that it greatly facilitates interpretation of the predictive model. Copyright © 2011 John Wiley & Sons, Ltd.
Dearomatisation of o‐Xylene by P450BM3 (CYP102A1)
Authors: Whitehouse Christopher J. C. , Rees Nicholas H. , Bell Stephen G. , Wong Luet‐Lok 
Published: April 2011

AbstractThe oxidation of o‐xylene by P450BM3 from Bacillus megaterium yields, in addition to the products formed by microsomal P450s, two metabolites containing an NIH‐shifted methyl group, one of which lacks the aromatic character of the substrate. The failure of the epoxide precursor of these two products to rearrange to the more stable 2,7‐dimethyloxepin suggests that ring opening is P450‐mediated. With m‐xylene, the principal metabolite is 2,4‐dimethylphenol. The partition between aromatic and benzylic hydroxylation is primarily governed by the steric prescriptions of the active site rather than by CH bond reactivity. It is also substrate‐dependent, o‐ and m‐xylene appearing to bind to the enzyme in different orientations. The product distributions given by variants containing the F87A mutation, which creates additional space in the active site, resemble those reported for microsomal systems.
Unexpected efficiency of non‐C2‐symmetric bis(hydroxyamide)‐based zinc‐chelate catalysts
Authors: Sánchez‐Carnerero Esther M. Márquez , de las Casas Engel Tomás , Lora Maroto Beatriz , de la Moya Cerero Santiago 
Published: April 2011

AbstractAsymmetric bis(hydroxyamide)‐based zinc‐chelate catalysts are able to promote the enantioselective addition of diethylzinc to benzaldehyde in the absence of titanium with yields and ees comparable, or inclusively superior, to their C2‐symmetric analogues. This unexpected fact demonstrates that the previously established assumption on the necessity of using C2‐symmetric bis(hydrdoxyamides) to generate C2‐symmetric zinc‐chelate catalysts can be discarded, which expand the possibilities for designing new ligands based on the interesting hydroxyl‐amide functional grouping. Chirality, 2011. © 2011 Wiley‐Liss, Inc.
Mechanical Properties of Ceramic Granules: Influence on Flow Behavior
Authors: Glöß Bianca , Fries Manfred , Nebelung Manfred 
Published: April 2011

AbstractKeramische Granulate weisen auf Grund ihres strukturellen Aufbaus duktile Eigenschaften auf. Diese im Vergleich zu primären Partikelsystemen besondere Eigenschaft hat Auswirkungen auf das Schüttgutverhalten. Im vorliegenden Beitrag werden erste Ergebnisse zum Einfluss der mechanischen Granulateigenschaften auf das Fließverhalten unter Berücksichtigung der Granulatgröße präsentiert.
Synthesis of Triazenoazaindoles: a New Class of Triazenes with Antitumor Activity
Authors: Diana Patrizia , Stagno Antonina , Barraja Paola , Carbone Anna , Parrino Barbara , Dall'Acqua Francesco , Vedaldi Daniela , Salvador Alessia , Brun Paola , Castagliuolo Ignazio , Issinger Olaf Georg , Cirrincione Girolamo 
Published: April 2011

AbstractDespite improvements in the treatment and prevention of cancer, the number of new diagnoses continues to rise; this has fuelled substantial interest in the development of new and effective chemotherapeutic agents. Compounds of the triazene class, such as dacarbazine, have been used in the clinical management of many cancer types including brain, leukemia, and melanoma. A new compound class bearing a triazenoazaindole scaffold was synthesized with the aim of identifying new antiproliferative agents. Compounds 5 a–g and 6 a–c were screened against a panel of human tumor cell lines, and two of them, 5 e and 5 f, showed cytotoxicity (GI50 range: 2.2–8.2 μM) in all cell lines. These two compounds even maintained their cytotoxicity in some multidrug‐resistant cell lines. Flow cytometry analysis demonstrated their ability to induce cell death by apoptosis with involvement of lysosomes.
Providing developmentally appropriate psychosocial care to adolescent and young adult cancer survivors
Authors: D'Agostino Norma M. , Penney Annette , Zebrack Brad 
Published: April 2011

AbstractTo deliver developmentally appropriate psychosocial care, the key developmental tasks facing adolescents and young adults (AYA) need to be taken into consideration. These include establishing autonomy from parents; a personal set of values and identity; strong peer relationships, including intimate and sexual relationships; and obtaining adequate preparation to join the workforce. To minimize the amount of disruption caused by the cancer experience and to maximize the health‐related quality of life of AYA patients, young individuals with cancer need opportunities to participate as much as possible in typical AYA activities and to master the developmental tasks of this life stage. Promoting a sense of normalcy is essential. To achieve this, the health care environment must be flexible and recognize the important role of peers. Informational and practical supports also are necessary for AYA to stay on track developmentally in the context of coping with cancer. Critical elements of effective AYA psychosocial services should include access to AYA‐specific information and support resources, fertility and sexuality counseling, programs to maximize academic and vocational functioning, and financial support. Cancer 2011;117(10 suppl):2329–34. © 2011 American Cancer Society..
Oncofertility and preservation of reproductive capacity in children and young adults
Authors: Wallace W. Hamish B. 
Published: April 2011

AbstractWith increasing numbers of survivors from cancer at a young age, the issue of fertility preservation has assumed greater importance. This review describes normal ovarian and testicular function and summarizes what is known about the effect of chemotherapy and radiotherapy on the gonads and uterus. All young patients with cancer or leukemia should have their fertility prognosis discussed before the initiation of treatment. Sperm and embryo cryopreservation should be considered standard practice and be widely available for those at significant risk of infertility. For prepubertal girls, ovarian tissue cryopreservation should be considered if the risk of premature menopause is high, but for the prepubertal boy there are no established techniques in current practice. Cancer 2011;117(10 suppl):2301–10. © 2011 American Cancer Society.