bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atypical antipsychotic use and risk of fracture in persons with Parkinsonism
Authors: Dore David D. , Trivedi Amal N. , Mor Vincent , Friedman Joseph H. , Lapane Kate L. 
Published: July 2009

AbstractOur objective was to estimate the effect of atypical antipsychotics (AAs) on the rate of fractures in a parkinsonism population. We conducted an age‐ and state‐matched nested case‐control study in five states (CA, FL, NY, OH, IL) using the Medicaid analytic extract from 2001 to 2002. Eligible participants had a diagnosis of parkinsonism, excluding persons with secondary parkinsonism, bone cancer, bone infections, schizophrenia, schizoaffective disorder, and those who used conventional antipsychotics. The primary outcome was the occurrence of a fracture of the femur, ankle, fibula, tibia, humerus, radius, or ulna (N = 851). Risk‐set sampling defined controls (N = 4220). We used conditional‐logistic regression to derive adjusted odds ratios (AOR) and 95% confidence intervals of the association between fracture and use of quetiapine, risperidone, or olanzapine in the 60 days before the index date compared to nonuse. After adjustment for confounding, use of quetiapine (AOR 2.4; 95% CI 1.5–3.8), risperidone (AOR 1.2; 95% CI 0.9–1.7), or olanzapine (AOR 1.7; 95% CI 1.2–2.4) was associated with a higher rate of fracture. Use of an AA was associated with a higher rate of fracture in persons with parkinsonism. Prescribers must be cautious when using these agents in elderly persons with parkinsonism. © 2009 Movement Disorder Society
Metabolic characterization of primary and metastatic ovarian cancer by 1H‐MRS in vivo at 3T
Authors: McLean Mary A. , Priest Andrew N. , Joubert Ilse , Lomas David J. , Kataoka Masako Y. , Earl Helena , Crawford Robin , Brenton James D. , Griffiths John R. , Sala Evis 
Published: July 2009

Abstract1H‐MRS was performed on 12 women (age range 45–72) with ovarian cancer of FIGO stage 3 or above using a 3T MRI system with an 8‐channel cardiac receive coil. Respiratory‐triggered PRESS‐localized spectra (TE = 144 ms) were obtained separately from an ovarian mass and from metastatic disease. Peak areas were quantified relative to unsuppressed water using LCModel and spectra were discarded if LCModel reported signal‐to‐noise ratio (SNR) < 3 or if no metabolites were reported with standard deviation (SD) < 30%. The cystic fraction of each voxel was estimated by thresholding T2‐weighted images, and this was used both to correct the reported metabolite concentrations and to calculate an expected SNR of choline using the measured SNR of water. Choline was detected in 10/12 primary tumors and 5/11 metastatic lesions (range 2.0–16.6 mM). Of the 8/23 failures, 7 had a predicted choline SNR < 2, confirming that the failure to detect choline could be explained by technical problems. Glycine was observed in one benign lesion. 1H‐MRS can be used to quantify choline in primary and metastatic masses in ovarian cancer, but the moderately high rate of failure to detect choline necessitates careful recording of data quality parameters to discriminate true from false negatives. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
Automatic high‐order shimming using parallel columns mapping (PACMAP)
Authors: Zhang Yan , Li Shizhe , Shen Jun 
Published: July 2009

AbstractThis work presents a new automatic high‐order shimming method that maps the B0 field using a group of parallel columns. We found that a pair of four columns in two separate slices could determine an optimal correction field comprising the spherical harmonic terms up to the third‐order. The technique of multiple stimulated echoes was incorporated into the method, allowing the use of at least eight shots to accomplish field mapping. The shim currents were first determined in the logic frame by assuming that the slices were in axial planes, and then uniquely converted into the physical frame where the slices could be at any oblique angle, by using a spherical harmonics rotation transformation. This method thus works regardless of slice orientation. It was demonstrated on a 3T scanner equipped with a complete set of second‐order harmonic shim coils. Both phantom and in vivo experiments showed that this newly introduced high‐order shimming method is an effective and efficient way to reduce field inhomogeneity for a region of imaging slices. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.
A RYR1 mutation associated with recessive congenital myopathy and dominant malignant hyperthermia in Asian families
Authors: Carpenter Danielle , Ismail Azzam , Robinson Rachel L. , Ringrose Christopher , Booms Patrick , Iles David E. , Halsall P. Jane , Steele Derek , Shaw Marie‐Anne , Hopkins Philip M. 
Published: July 2009

AbstractIn this study we present 3 families with malignant hyperthermia (MH), all of Indian subcontinent descent. One individual from each of these families was fully sequenced for RYR1 and presented with the non‐synonymous change c.11315G>A/p.R3772Q. When present in the homozygous state c.11315*A is associated with myopathic symptoms. Muscle Nerve, 2009
Survey of SNMP performance analysis studies
Authors: Andrey Laurent , Festor Olivier , Lahmadi Abdelkader , Pras Aiko , Schönwälder Jürgen 
Published: July 2009

AbstractThis paper provides a survey of Simple Network Management Protocol (SNMP)‐related performance studies. Over the last 10 years, a variety of such studies have been published. Performance benchmarking of SNMP, like all benchmarking studies, is a non‐trivial task that requires substantial effort to be performed well and achieve its purpose. In many cases, existing studies have employed different techniques, metrics, scenarios and parameters. The reason for this diversity is the absence of a common framework for SNMP performance analysis. Without such a framework, results of SNMP‐related performance studies cannot easily be compared, extended or reused. It is therefore important to start a research activity to define such a framework. Such research activity should start from analysing previous studies on this topic to reveal their employed methods. In this survey we examine these studies by classifying and discussing them. We present techniques, approaches and metrics employed by these studies to quantify the performance of SNMP‐based applications. Copyright © 2009 John Wiley & Sons, Ltd.
The mechanism for fracture resistance in β‐nucleated isotactic polypropylene
Authors: Xu Linli , Xu Kai , Zhang Xiuju , Liu Feiyue , Chen Mingcai 
Published: July 2009

AbstractThe effects of molecular weight (MW) of isotactic polypropylene (iPP), the content of β‐PP, the size of its spherulites and the morphology of its α‐phase and β‐phase (α‐ and β‐PP) on the impact strength, with different contents of β‐nucleating agent, were investigated by two ways. The results show that the impact strength of iPPs increased initially, and then decreased with the content of β‐nucleating agent (maximum at 0.1 wt%). The impact strength was related to the size of β‐spherulites and had no apparent correlation with the content of β‐PP. The morphology of the bundle shape and intercrossing boundaries of β‐spherulites were dominant in improving impact strength with low content of β‐nucleating agent, while the MW of iPP was dominant with high content of β‐nucleating agent. Copyright © 2009 John Wiley & Sons, Ltd.
Antibody microarray analysis of serum glycans in esophageal squamous cell carcinoma cases and controls
Authors: Shao Changxia , Chen Songming , Chen Lixia , Cobos Everardo , Wang Jia‐Sheng , Haab Brian B. , Gao Weimin 
Published: July 2009

AbstractThe objective of this study was to characterize specific serum glycan profile in esophageal squamous cell carcinoma (ESCC) cases and matched controls. A recently developed lectin‐based antibody array was applied to detect various cancer‐associated glycotopes in sera from 23 cases and 23 controls. Glycan levels were highly expressed in sera of ESCC patients as compared with controls. These included fucosylation level on interleukin (IL) 8; mannose level on haptoglobin; N‐acetylglucosamine levels on IL6, mucin (MUC)1, and von Willebrand factor (vWf); sialyl Lewis a (sLea) levels on blood group Lewis X, IL6, IL10, MUC1, and serum amyloid A (SAA); sialyl Tn antigen (sTn) levels on cathepsin D, gelsolin, IL10, and vWf; T antigen levels on IL8, IL10, blood group Lewis X, vitronectin, and vWf (p<0.05). In addition, receiver‐operating characteristics (ROC) analysis showed significantly discriminal improvement between cases and controls as measured by area under ROC curve. The highest sum of sensitivity and specificity was 1.52 for carbohydrate antigen 19‐9 detection on both MUC1 and SAA, with area under ROC curves of 0.73 and 0.71, respectively. Taken together, this lectin‐based antibody microarray allows efficient profiling of variations in specific glycans on proteins in ESCC cases as compared with controls, some of which might be useful for clinical diagnosis, early detection, and/or treatment.
Selectivity in radical alkylation of substituted pyrroles
Authors: Iuga Cristina , Uribe Simón Olguín , Miranda Luis D. , Vivier‐Bunge Annik 
Published: July 2009

AbstractThe theoretical study of a highly regioselective intermolecular oxidative free‐radical substitution of 2‐ and 3‐formylpyrroles that yields 2,5‐ and 2,3‐disubstituted pyrroles, respectively, is described. A mechanistic and kinetic study was carried out using quantum chemical methods and classical transition state theory. Rate constants were obtained at 298 K and atmospheric pressure. All possible channels were considered and branching ratios were obtained. The selectivity predicted using theoretical methods agrees very‐well with experimental results. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
CHAMBER: Comprehensive support for CHARMM force fields within the AMBER software
Authors: Crowley Michael F. , Williamson Mark J. , Walker Ross C. 
Published: July 2009

AbstractThe similarity of the AMBER force field's energy functional form with that of the CHARMM force field, gives the potential for direct translation of common bonding and nonbonding terms, along with their parameters, present in CHARMM topology and parameter files, with the intent of evaluation within the AMBER software; specifically the SANDER and PMEMD dynamics engines. To this extent, we have created a tool, CHAMBER, which can take a CHARMM protein structure file (PSF), coordinate file (COR) and associated forcefield files, and convert these to an AMBER topology file (prmtop) and associated coordinate file (inpcrd). CHAMBER opens a conversion route which enables the simulation of CHARMM parameterized models using AMBER's PMEMD engine; thus providing improved serial efficiency as well as parallel efficiency over large numbers of CPUs. Significant effort has been expended in ensuring a true representation of the CHARMM force field in AMBER providing energies and forces that are the same to the limits of machine precision. This software will be released in the upcoming version 1.3 of the free AMBERTools suite.1© 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2009
Estimation of effective exchange integral value of polyradical systems based on the band calculation
Authors: Nakanishi Yasuyuki , Kitagawa Yasutaka , Saito Toru , Kataoka Yusuke , Matsui Toru , Kawakami Takashi , Okumura Mitsutaka , Yamaguchi Kizashi 
Published: July 2009

AbstractEffective exchange integral (Jab) values calculated by cluster models were compared with values calculated under the periodic boundary conditions. So far, to estimate the Jab value of a macro system, we have considered that of the corresponding to cluster one. However, they will get absolutely nothing out of it if a cluster model and the periodic boundary conditions method give different results to us. The main aim of this report is to give an opinion to this issue using a one‐dimensional polyhydrogen system as example. © 2009 Wiley Periodicals, Inc. Int J Quantum Chem, 2009
Consensus of multiple double‐integrator agents with intermittent measurement
Authors: Gao Yanping , Wang Long 
Published: July 2009

AbstractThis paper is concerned with consensus problems in directed networks of multiple agents with double‐integrator dynamics. It is assumed that each agent adjusts its state based on the information of its states relative to its neighbors at discrete times and the interaction topology among agents is time‐varying. Both synchronous and asynchronous cases are considered. The synchrony means that each agent's update times, at which it obtains new control signals, are the same as the others', and the asynchrony implies that each agent's update times are independent of the others'. In the synchronous case, the consensus problem is proved to be equivalent to the asymptotic stability problem of a discrete‐time switched system. By analyzing the asymptotic stability of the discrete‐time switched system, it is shown that consensus can be reached if the update time intervals are small sufficiently, and an allowable upper bound of update time intervals is obtained. In the asynchronous case, the consensus problem is transformed into the global asymptotic stability problem of a continuous‐time switched system with time‐varying delays. In virtue of a linear matrix inequality method, it is proved that consensus can be reached if the delays are small enough, and an admissible upper bound of delays is derived. Simulations are provided to illustrate the effectiveness of the theoretical results. Copyright © 2009 John Wiley & Sons, Ltd.
Disturbance and riverine benthic communities: What has it contributed to general ecological theory?
Authors: Death Russell G. 
Published: July 2009

AbstractDisturbance from floods and/or low flows is a pervading force in almost all benthic riverine communities around the world. As such the study of disturbance effects on benthic communities has been a dominant theme of research in benthic river ecology. Many of these studies have been phenomenological or have evaluated hypotheses developed in other areas of ecology. These studies have provided considerable weight to move the common view of ecological communities in general as deterministically structured, to one where stochastic disturbances can be the dominant structuring force in many communities. Benthic river studies investigating the link between disturbance and diversity have generally failed to find support for single variable hypotheses, such as the intermediate disturbance hypothesis, from other areas of ecology, however, river ecologists have been among the first to embrace multivariate models of diversity. The highly mobile, larval life history stage of many riverine invertebrates makes many of the hypotheses generated in general ecology inappropriate for benthic river communities; however, the recently popularized neutral models may prove to be good descriptors of these communities. Food web structure studies indicate riverine webs respond differently to disturbance from the way predicted by ecological theory. The contribution of studies of disturbance in benthic ecology to general ecology has to date been rather limited with some notable exceptions. However, the ubiquity of floods in rivers worldwide offers fertile ground for future contributions that could substantially advance this area of ecology. Benthic river ecologists need to resist the temptation to simply show general ecological models often do not work in streams, and need to develop their own models, which in turn may feed back to wider ecology. Copyright © 2009 John Wiley & Sons, Ltd.
Controlled Intracellular Release of Peptides from Microcapsules Enhances Antigen Presentation on MHC Class I Molecules
Authors: Palankar Raghavendra , Skirtach André G. , Kreft Oliver , Bédard Matthieu , Garstka Malgorzata , Gould Keith , Möhwald Helmuth , Sukhorukov Gleb B. , Winterhalter Matthias , Springer Sebastian 
Published: July 2009

AbstractTo understand the time course of action of any small molecule inside a single cell, one would deposit a defined amount inside the cell and initiate its activity at a defined moment. An elegant way to achieve this is to encapsulate the molecule in a micrometer‐sized reservoir, introduce it into a cell, remotely open its wall by a laser pulse, and then follow the biological response by microscopy. The validity of this approach is validated here using microcapsules with defined walls that are doped with metallic nanoparticles so as to enable them to be opened with an infrared laser. The capsules are loaded with a fluorescent antigenic peptide and introduced into mammalian cultured cells where, upon laser‐induced release, the peptide binds to major histocompatibility complex (MHC) class I proteins and elicits their cell surface transport. The concept of releasing a drug inside a cell and following its action is applicable to many problems in cell biology and medicine.
User‐level operating system transactions
Authors: Spinellis Diomidis 
Published: July 2009

AbstractUser‐level operating system transactions allow system administrators and ordinary users to perform a sequence of file operations and then commit them as a group, or abort them without leaving any trace behind. Such a facility can aid many system administration and software development tasks. The snapshot isolation concurrency control mechanism allows transactions to be implemented without locking individual system calls; conflicts are detected when the transaction is ready to commit. Along these lines we have implemented a user‐space transaction monitor that is based on ZFS snapshots and a file system event monitor. Transactions are committed through a robust and efficient algorithm that merges the operations performed on a file system's clone back to its parent. Both the performance impact and the implementation cost of the transaction monitor we describe are fairly small. Copyright © 2009 John Wiley & Sons, Ltd.
Effects of infill walls on base responses and roof drift of reinforced concrete buildings under time‐history loading
Authors: Kose M. Metin , Karslioglu Ozge 
Published: July 2009

AbstractIn this study, the effects of infill walls on base reaction and roof drift of reinforced concrete frames were investigated. These effects were studied using 3D finite element method on 216 building models. Number of floors, number of bays, ratio of shear walls and ratio of infilled bays were selected as parameters. Sensitivity analysis was performed to determine the effect of each parameter on base shear, normal base reaction and roof drift. Based on the sensitivity analysis, the percentage of shear walls was the most important parameter affecting base shear, normal base reaction and roof drift. The effect of infill walls on base shear, normal base reaction and roof drift decreased when the percentage of the shear walls increased. The models without any infill walls had minimal normal base reaction under time‐history loading. However, an increase in the percentage of infill walls led to an increase in normal base reaction. The roof drift of the models was not critical. Copyright © 2009 John Wiley & Sons, Ltd.
Perineural (Tarlov) cysts mimicking adnexal masses: a report of three cases
Authors: H'ng M. W. C. , Wanigasiri U. I. D. K. , Ong C. L. 
Published: July 2009

AbstractPerineural (Tarlov) cysts are usually incidental findings during magnetic resonance imaging (MRI) performed for low back pain. However, in a tertiary women's hospital, they may present as incidental findings on gynecological ultrasound imaging. Approximately 40 000 pelvic scans are performed annually in our department. Tarlov cysts were identified in three women between August 2007 and September 2008. In two patients (Cases 1 and 3), these cysts were initially misdiagnosed as hydrosalpinges on ultrasound examination, the latter having a differential diagnosis of an ovarian cyst. Two patients (Cases 1 and 2) were symptomatic, although Case 2 had symptoms that could not entirely be accounted for by the location of the cyst. Although asymptomatic, Case 3 underwent laparoscopy with a view to salpingectomy/cystectomy. In these patients, confirmation of Tarlov cysts was subsequently made on either computed tomography (CT) or MRI. All three patients were managed conservatively. Here we describe their clinical presentation, the appearance of the cysts on ultrasound imaging and on CT or MRI, and their eventual outcomes. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.
Hypertensive disorders in pregnancy: screening by uterine artery Doppler at 11–13 weeks
Authors: Poon L. C. Y. , Staboulidou I. , Maiz N. , Plasencia W. , Nicolaides K. H. 
Published: July 2009

AbstractObjectivesTo examine the performance of screening for hypertensive disorders in pregnancy by a combination of the maternal factor‐derived a‐priori risk with the uterine artery (UtA) pulsatility index (PI) and to determine whether it is best in such screening to use the mean PI of the two arteries, the highest PI or the lowest PI.MethodsThis was a prospective screening study for pre‐eclampsia (PE) requiring delivery before 34 weeks (early PE), late PE and gestational hypertension (GH) in women attending their routine first hospital visit in pregnancy at 11 + 0 to 13 + 6 weeks of gestation. Maternal history was recorded and color flow Doppler imaging was used to measure the left and right UtA‐PI. The performance of screening for PE and GH by a combination of the maternal factor‐derived a‐priori risks determined in a previous study and the UtA‐PI was assessed.ResultsThere were 8061 (96.4%) cases unaffected by PE or GH, 37 (0.4%) that developed early PE, 128 (1.5%) with late PE and 140 (1.7%) with GH. The lowest, mean and highest UtA‐PI were significantly higher in early PE and late PE than in the controls (P < 0.0001) and in early PE than late PE (P < 0.0001). The lowest UtA‐PI was higher in GH than in controls (P = 0.014). The best performance in screening was provided by the lowest PI. The detection rate of early PE at a 10% false‐positive rate increased from 47% in screening by maternal factors alone to 81% in screening by maternal factors and the lowest UtA‐PI. The respective detection rates for late PE increased from 41% to 45% and those for GH increased from 31% to 35%.ConclusionsThe patient‐specific risk for PE and GH can be derived by combining the disease‐specific maternal factor‐derived a‐priori risk with the measurement of the lowest UtA‐PI in a multivariate regression model. Copyright © 2009 ISUOG. Published by John Wiley & Sons, Ltd.