bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antimicrobial Properties and Cytotoxicity of an Antimicrobial Monomer for Application in Prosthodontics
Authors: Regis Rômulo Rocha , Vecchia Maria Paula Della , Pizzolitto Antônio Carlos , Compagnoni Marco Antonio , Souza Pedro Paulo Chaves , Souza Raphael Freitas de 
Published: February 2012

AbstractPurpose: This study aimed to investigate the antimicrobial properties and cytotoxicity of the monomer methacryloyloxyundecylpyridinium bromide (MUPB), an antiseptic agent capable of copolymerizing with denture base acrylic resins.Materials and Methods: The antimicrobial activity of MUPB was tested against the species Candida albicans, Candida dubliniensis, Candida glabrata, Lactobacillus casei, Staphylococcus aureus, and Streptococcus mutans. The minimum inhibitory and fungicidal/bactericidal concentrations (MIC, MFC/MBC) of MUPB were determined by serial dilutions in comparison with cetylpyridinium chloride (CPC). The cytotoxic effects of MUPB at concentrations ranging from 0.01 to 1 g/L were assessed by MTT test on L929 cells and compared with methyl methacrylate (MMA). The antimicrobial activity of copolymerized MUPB was tested by means of acrylic resin specimens containing three concentrations of the monomer (0, 0.3, 0.6% w/w). Activity was quantified by means of a disc diffusion test and a quantification of adhered planktonic cells. Statistical analysis employed the Mann‐Whitney test for MIC and MFC/MBC, and ANOVA for the microbial adherence test (α= 0.05).Results: MUBP presented lower MIC values when compared with CPC, although differences were significant for C. dubliniensis and S. mutans only (p= 0.046 and 0.043, respectively). MFC/MBC values were similar for all species except C. albicans; in that case, MUPB presented significantly higher values (p= 0.046). MUPB presented higher cytotoxicity than MMA for all tested concentrations (p < 0.001) except at 0.01 g/L. Irrespective of the concentration incorporated and species, there was no inhibition halo around the specimens. The incorporation of MUPB influenced the adhesion of C. albicans only (p= 0.003), with lower CFU counts for the 0.6% group.Conclusions: It was concluded that non‐polymerized MUPB has an antimicrobial capacity close to that of CPC and high cytotoxicity when compared with MMA. The antimicrobial activity of MUPB after incorporation within a denture base acrylic resin did not depend on its elution, but was shown to be restricted to C. albicans.
Surgical and Prosthetic Considerations to Rehabilitate an Ocular Defect Using Extraoral Implants: A Clinical Report
Authors: de Negreiros Wagner Araujo , Verde Marcus Aurelio Rabelo Lima , da Silva Antonio Materson , Pinto Lecio Pitombeira 
Published: February 2012

AbstractThis clinical report shows the use of extraoral implants to rehabilitate an ocular defect, focusing the surgical and prosthetic procedures. Using local anesthesia and a surgical template obtained from the diagnostic wax ocular pattern, two cylinder dental implants were strategically placed in the lateral aspect of the right infraorbital region. Four months later, an acrylic framework including two spherical magnets was made using plastic UCLA abutments. After casting laboratory steps, a customized silicon prosthetic appliance was fabricated from the diagnostic wax ocular pattern and attached to the Co–Cr framework, observing its profile and seating aspects. The patient was satisfied with the treatment result, due to the retention, esthetics, and adhesive‐free method to anchor his ocular prostheses.
Assessment of the Ability to Relate Anterior Tooth Form and Arrangement to Gender
Authors: Ferreira Jassé Fernanda , Vilhena Corrêa Josiane , Ferreira Santos da Cruz Andréa , José Pantoja Fontelles Mauro , Ribeiro Roberto Andiara , Roberto Cury Saad José , Alves de Campos Edson 
Published: February 2012

AbstractPurpose: This study evaluated the assumption that there are morphological differences between the natural anterior dentition of men and women. The goal of the study was to determine the gender of patients based on the appearance of the anterior teeth in photographs.Materials and Methods: Laymen and observers from different specialties were asked to determine the gender of individuals based on the shape and arrangement of anterior teeth. Forty anterior dentition photographs of dental students of both genders (20 women, 20 men) between 18 and 26 years old were selected, coded, and randomly arranged in an album. The albums were delivered to five groups of observers: general practitioners (recently graduated dentists), prosthodontists, orthodontists, restorative dentists (specialists in cosmetic and restorative dentistry), and laymen (control group). The observers evaluated the photographs twice at 1‐week intervals.Results: The average correctly identified values in women and men were 57.6% and 58.8%, respectively. There was no statistical difference between observers and between each group of professionals and the laymen group (p > 0.05). An intraobserver agreement was not observed between the evaluations (kappa =−0.01).Conclusion: The results of this limited study indicated that it was not possible to differentiate gender by viewing photographs of anterior teeth.
Retrievable Metal Ceramic Implant‐Supported Fixed Prostheses with Milled Titanium Frameworks and All‐Ceramic Crowns: Retrospective Clinical Study with up to 10 Years of Follow‐Up
Authors: Maló Paulo , de Araújo Nobre Miguel , Borges João , Almeida Ricardo 
Published: February 2012

AbstractPurpose: The purpose of this study was to report on the outcome of metal ceramic implant‐supported fixed prostheses with milled titanium frameworks and all‐ceramic crowns.Materials and Methods: The clinical study included 108 patients (67 women, 41 men), mean age of 58.6 years (range: 34–82), followed between 9 months and 10 years (post occlusal loading). The mean follow‐up time for all patients in the study was 5 years. A total of 125 prostheses were fabricated. The data were divided into 2 groups. Development group (DG): 52 patients with 66 prostheses (28 maxillary, 38 mandibular) fabricated with individual Procera crowns (Alumina copings, Nobel Biocare AB) and Allceram ceramics (Ducera Dental GmbH) cemented onto a CAD/CAM fabricated Ti framework (Nobel Biocare AB) with pink ceramic (Duceram, Ducera Dental GmbH) that replicated the missing gingival tissues. Routine group (RG): 56 patients with 59 prostheses (49 maxillary, 10 mandibular) fabricated with individual Procera crowns (Zirconia copings and Nobel Rondo Zirconia Ceramic; Nobel Biocare AB) cemented onto a CAD/CAM fabricated Ti framework (Nobel Biocare AB) with pink acrylic resin (PallaXpress Ultra, Heraeus Kulzer GmbH) that replicated the missing gingival tissues. Primary outcome measures were prosthetic survival and mechanical complications. Secondary outcome measures were biological complications testing the retrievability characteristic of the prosthesis. Survival estimates were calculated on the patient level with the Kaplan‐Meier product limit estimator (95% confidence intervals [CI]). Data were analyzed with descriptive and inferential analyses.Results: The cumulative survival rates for the implant‐supported fixed prostheses were 92.4% for the DG at 10 years and 100% for the RG at 5 years (overall 96%) (Kaplan‐Meier). Mechanical complications occurred in 44 patients (DG: 29 patients, 36 prostheses; RG: 15 patients, 16 prostheses); the large majority were crown fractures, occurring in 48 patients (DG: 33 patients, 36 prostheses; RG: 15 patients, 16 prostheses). In the DG, univariate analysis of logistic regression disclosed the presence of a metal ceramic implant‐supported fixed prosthesis opposing dentition as a risk factor for crown fracture (OR = 1.97). Biological complications occurred in 33 patients (DG: 18 patients; RG: 15 patients), the majority being peri‐implant pathologies in 19 patients (DG: 9 patients, RG: 10 patients). All situations were resolved except one in the DG that led to fixture and prosthesis loss.Conclusions: The results of this study indicated that, within the limitations of this study, the CAD/CAM protocol is acceptable for definitive prosthetic rehabilitation. This protocol provided these patients with a good prognosis on a middle‐ to long‐term basis (5 years).
Evaluation of Zirconium‐Oxide‐Based Ceramic Single‐Unit Posterior Fixed Dental Prostheses (FDPs) Generated with Two CAD/CAM Systems Compared to Porcelain‐Fused‐to‐Metal Single‐Unit Posterior FDPs: A 5‐Year Clinical Prospective Study
Authors: Vigolo Paolo , Mutinelli Sabrina 
Published: February 2012

AbstractPurpose: The purpose of this prospective clinical study was to determine the success rate of single‐unit posterior fixed dental prostheses (FDPs) with zirconia copings generated with two CAD/CAM systems, compared to porcelain‐fused‐to‐metal (PFM) single‐unit posterior FDPs after 5 years of function.Materials and Methods: From 2005 to 2006, 60 patients who needed a single‐unit FDP on a first molar in the mandibular jaw (left or right) in a private office setting were included in this study. The 60 first mandibular molars were randomly divided into three groups (n = 20): in the control group (group C), 20 PFM FDPs were included. In the other two groups CAD/CAM technology was used for the fabrication of the zirconium‐oxide copings: 20 single‐unit posterior FDPs with zirconia copings were generated with the Procera system (group P, Nobel Biocare); 20 single‐unit posterior FDPs with zirconia copings were generated with the Lava system (group L, 3M ESPE). For the ANOVA follow‐up data, the clinical life table method was applied. The statistical analysis was performed using two nonparametric tests, the log‐rank test for k‐groups and the Fisher exact test.Results: No statistically significant difference in the clinical outcome of zirconia–ceramic FDPs of both groups (P and L) evaluated together and metal–ceramic posterior single FDPs was found at 5 years of function; however, clinical data showed that technical problems, such as extended fracture of the veneering ceramic, tended to occur more frequently in the zirconia–ceramic FDP groups. The difference in the frequency of failure was statistically significant only in the comparison of groups C and P.Conclusions: Even if no statistically significant difference in the clinical outcome of zirconia–ceramic FDPs of both groups (P and L) considered together and metal–ceramic posterior single FDPs was found at 5 years of function, clinical data showed that the two zirconia–ceramic FDP groups tended to have more frequent clinical problems: for this reason all the clinical and technical variables related to the use of zirconia–ceramic FDPs generated with CAD/CAM systems should be carefully considered prior to all treatment procedures.
Comparative Evaluation of Fracture Resistance of Structurally Compromised Canals Restored with Different Dowel Methods
Authors: Aggarwal Vivek , Singla Mamta , Miglani Sanjay , Kohli Sarita 
Published: February 2012

AbstractPurpose: The objective of this in vitro study was to evaluate and compare the fracture resistance and fracture mode of endodontically treated teeth with wide root canals restored with various dowel methods.Materials and Methods: Fifty human uniradicular mandibular premolar teeth were decoronated and endodontically treated. The canals were widened with diamond points. The specimens were divided into five groups on the basis of type of dowel method used: conventional custom‐made cast metal dowel; single glass fiber‐reinforced resin dowel; glass fiber‐reinforced resin dowel with accessory fiber dowels; relined glass fiber‐reinforced resin dowel; and dowels formed with the help of polyethylene fiber ribbon‐reinforced resin composite. Specimens were restored with indirect composite crowns, and 150,000 cycles of cyclic loading were applied. The specimens were loaded to test the fracture resistance and fracture mode (repairable and nonrepairable).Results: The cast metal dowel groups had the highest fracture resistance but showed nonrepairable fracture in 90% of specimens.Conclusions: Cast metal dowels had the highest fracture resistance but led to nonrepairable fracture while restoring the wide root canals under cyclic loading. Specimens restored with fiber dowels, accessory dowels, relined dowels, and ribbon‐reinforced resin provided adequate fracture resistance with increased incidence of repairable fractures.
Transesophageal Evaluation of Asymptomatic Wolff‐Parkinson‐White Syndrome
Authors: TONI LOUAY , BLAUFOX ANDREW D. 
Published: February 2012

Background:

Risk stratification for Wolff‐Parkinson‐White (WPW) by intracardiac electrophysiology study (ICEPS) carries risks related to catheterization. We describe an alternative approach by using transesophageal electrophysiology study (TEEPS).
Methods:

The pediatric electrophysiology database was reviewed for patients with WPW and no documented clinical supraventricular tachycardia (SVT) who underwent risk stratification by TEEPS from October 2005 to November 2010. Of those who underwent subsequent ICEPS, only those with data available to compare accessory pathway (AP) conduction during ICEPS and TEEPS were included.
Results:

Of 65 patients who underwent TEEPS, 42 were found to have an indication for ablation. The most common indication for ICEPS was inducible SVT, which was induced in 67% of patients. Of 42 patients who underwent subsequent ICEPS, 23 had sufficient data for comparison of AP conduction between ICEPS and TEEPS. There was no difference between the baseline minimum 1:1 antegrade conduction through the accessory pathway found at TEEPS versus ICEPS (312 ± 51 ms vs 316 ± 66 ms, P = 0.5). There was no significant difference between the baseline antegrade AP‐effective refractory period found at TEEPS versus ICEPS (308 ± 34 ms vs 297 ± 37 ms, P = 0.07). There were no complications related to TEEPS or ICEPS.
Conclusion:

TEEPS is a safe and feasible alternative to ICEPS for risk stratification in patients with asymptomatic WPW and should be considered before ICEPS and ablation. (PACE 2012; 1–5)
Effect of a Pacing Mode Preserving Spontaneous AV Conduction on Ventricular Pacing Burden and Atrial Arrhythmias
Authors: REY JEAN‐LUC , QUENUM SERGE , HERO MARC 
Published: February 2012

Background:
Using dual‐chamber pacemakers with new algorithms: Manage Ventricular Pacing (MVP™), minimizes unnecessary ventricular pacing (VP). This function operates in AAI/R mode with backup VP during AV block.
Aim:
The aim of “Generation MVP” study was to assess the VP burden and atrial arrhythmias (AA) burden according to indication of pacing and MVP™ function programming of AdaptaDR implantable pacemaker (Medtronic Inc., Minneapolis, MN, USA).
Methods:
The multicenter observational “Generation MVP” study included 220 patients aged 75.9 ± 11 years (men = 52%) implanted for sinus node dysfunction (SND; n = 115) or atrio‐ventricular block (AVB; n = 105). Programming MVP function has been left to the physician's discretion. Percentage of VP and AA burden (percentage of time spent in AA) stored in memories were assessed at 2 and 10 months.
Results:
220 patients were followed at 2 months (174 MVP [On], 46 MVP [off]) and at 10 months (165 MVP [On], 55 MVP [off]). Median percentage of VP is significantly lower when MVP is programmed [On] versus [off] at 2 and 10 months follow‐up for SND and AVB indications of pacing (P < 0.001). Finally, programming MVP function is performed at middle term (10 months) for 84% of patients with SND and 65% of patients with AVB: median percentage of VP is as low as 0.6% for patients with SND and 12% for patients with AVB versus 95% for SND and 99% for AVB when MVP function is programmed [off](P < 0.001).Median AA burden was significantly lower when MVP function was programmed [On] versus [off] at 2 months (8.7% vs 28%; P < 0.001) and 10 months (1% vs 22%; P < 0.001).
Conclusion:
In this study programming MVP function decreases percentage of VP at 2 and 10 months for patients paced for SND or AVB. Moreover median AA burden is reduced when MVP function was programmed [On] vs [off] at two follow‐ups. (PACE 2012; 1–6)
One‐Year Clinical Outcomes after Sirolimus‐Eluting Coronary Stent Implantation for Acute Myocardial Infarction in the Worldwide e‐SELECT Registry
Authors: WORTHLEY STEPHEN G. , ABIZAID ALEXANDRE , BANNING ADRIAN , BARTORELLI ANTONIO , DŽAVÍk VLADIMÍR , ELLIS STEPHEN , GAO RUNLIN , LEGRAND VICTOR , URBAN PHILIP , SPAULDING CHRISTIAN ,   for the e‐SELECT investigators
Published: February 2012

Background:

The aim was to ascertain the 1‐year clinical outcomes of 1,234 patients who underwent implantations of sirolimus‐eluting stents (SES) for acute myocardial infarction (MI) in the multinational e‐SELECT registry.
Methods:

Fifteen thousand and one hundred and forty‐seven patients treated with SES were entered in the e‐SELECT registry, of whom 1,234 presented within <24 hours of onset of acute MI.
Results:

At 1 year, the rates of major adverse cardiac events (MACE) (5.5% vs. 4.8%; P = 0.28) were similarly low in the acute and no acute MI groups. The rates of definite/probable stent thrombosis (ST) were higher in the acute MI group (2.1%vs; 0.88%, P < 0.001). ST was a strong independent predictor of death at 1 year (HR 13.4; 95% CI 5.0, 36.0; P < 0.001) and MI (HR 58.9; 95% CI 26.9, 129.1; P < 0.001). Dual antiplatelet therapy (DAPT) compliance at 6 months was 96.0% in the acute MI versus 94.5% in the no acute MI group (P = 0.03).
Conclusion:

In selected patients presenting within <24 hours of acute MI onset and highly compliant with DAPT, SES implantation was associated with similar rates of MACE, though higher rates of ST, as compared to no acute MI patients.Condensed abstract  In the e‐SELECT registry which included 15,147 patients treated with sirolimus‐eluting stent (SES), we ascertained the 1‐year clinical outcomes of 1,234 patients who presented within <24 hours of acute MI onset. In acute MI patients SES implantation was associated with similar rates of MACE, though higher rates of ST, as compared to no acute MI patients (MACE: 5.5% vs. 4.8%; P = 0.28; ST: 2.1 vs. 0.88%, P < 0.001). (J Interven Cardiol 2012;25:253–261)
Up‐regulation of miR‐210 by vascular endothelial growth factor in ex vivo expanded CD34+ cells enhances cell‐mediated angiogenesis
Authors: Alaiti Mohamad Amer , Ishikawa Masakazu , Masuda Haruchika , Simon Daniel I. , Jain Mukesh K. , Asahara Takayuki , Costa Marco A. 
Published: February 2012

AbstractEx vivo culture has been proposed as a means to augment and repair autologous cells in patients with chronic diseases, but the mechanisms governing improvement in cell function are not well understood. Although microRNAs (miRs) are increasingly appreciated as key regulators of cellular function, a role for these factors in CD34+ cell‐mediated angiogenesis has not been elucidated. Vascular endothelial growth factor (VEGF) was previously shown to induce expression of certain miRs associated with angiogenesis in endothelial cells and promote survival and number of vascular colony forming units of haematopoietic stem cells (HSCs). We sought to evaluate the role of VEGF in expansion and angiogenic function of CD34+ cells and to identify specific miRs associated with angiogenic properties of expanded cells. Umbilical cord blood CD34+ cells were effectively expanded (18‐ to 22‐fold) in culture medium containing stem cell factor (SCF), Flt‐3 ligand (Flt‐3), thrombopoietin (TPO) and interleukin‐6 (IL‐6) with (postEX/+VEGF) and without VEGF (postEX/noVEGF). Tube formation in matrigel assay and tissue perfusion/capillary density in mice ischaemic hindlimb were significantly improved by postEX/+VEGF cells compared with fresh CD34+ and postEX/noVEGF cells. MiR‐210 expression was significantly up‐regulated in postEX/+VEGF cells. MiR‐210 inhibitor abrogated and 210 mimic recapitulated the pro‐angiogenic effects by treatment of postEX/+VEGF and postEX/noVEGF cells respectively. Collectively, these observations highlight a critical role for VEGF in enhancing the angiogenic property of expanded cells, and identify miR‐210 as a potential therapeutic target to enhance CD34+ stem cell function for the treatment of ischaemic vascular disease.
Predictive value of early radiological findings in inflicted traumatic brain injury
Authors: Tanoue Koji , Matsui Kiyoshi , Nozawa Kumiko , Aida Noriko 
Published: February 2012

AbstractAim:  The aim of this study was to evaluate the value of early radiological investigations in predicting the long‐term neurodevelopmental outcome of patients with inflicted traumatic brain injury (ITBI).Methods:  In 28 patients with ITBI, radiological investigations were performed during the acute phase of injury (0–3 days) and during the early post‐injury phase (4 days to 1 month). The clinical outcome in survivors (n = 24) was based on the Glasgow Outcome Score.Results:  Four of 28 infants died and five were severely disabled. Six infants had moderate disability. Detection of changes in the basal ganglia (p < 0.000005) or brainstem (p < 0.01), diffuse oedema (p < 0.005), transtentorial herniation (p < 0.01), subarachnoid haemorrhage (p < 0.05) or parenchymal injury (p < 0.05) by neuroimaging during the first 3 days, and detection of changes in the basal ganglia (p < 0.0005) or brainstem (p < 0.05) or parenchymal injury (p < 0.01) during 1 month were significantly associated with poor long‐term outcome.Conclusion:  Radiological findings during the first month were significantly associated with the long‐term outcome. Especially, basal ganglia lesions were associated with a poor outcome.
Chewing disability in older adults attributable to tooth loss and other oral conditions
Authors: Singh Kiran A. , Brennan David S. 
Published: February 2012

doi: 10.1111/j.1741‐2358.2010.00412.xChewing disability in older adults attributable to tooth loss and other oral conditionsBackground:  This study evaluates associations between oral health‐related factors and chewing ability, and quantifies the risk contributed by each factor.Materials and methods:  Chewing ability and information on number of teeth, dentures and dental problems over the last 12 months were collected by mailing questionnaires to a random sample of 60‐ to 71‐year‐olds from Adelaide, South Australia. Logistic regression was used to model oral status and oral symptoms as predictors of chewing disability, and to estimate the population‐attributable fraction.Results:  A total of 444 persons responded (response rate = 68.8%). Among dentate subjects, 10.3% were chewing‐deficient, with chewing disability more prevalent (p < 0.05) among those with <21 teeth (26.4%), dentures (20.4%), painful aching in the mouth (25.4%), pain in the face (16.7%), broken/chipped teeth (15.6%), sensitive teeth (14.1%), loose teeth (37.1%), and sore gums (18.0%). Adjusted Odds ratios (OR) showed inadequate dentition (OR = 4.20), painful aching in the mouth (OR = 4.88), and presence of loose teeth (OR = 4.70) were associated with chewing disability (p < 0.01), and their population attributable fractions were 18.5%, 15.1% and 7.8% respectively.Conclusions:  Loose teeth, number of teeth and pain in the mouth were associated with chewing disability, with an inadequate dentition and pain in the mouth contributing most to chewing disability in this population.