Analysis of the Impact of Intensive Clinical Management of Cardiovascular Risk Factors in Patients With Type 1 Diabetes: Prevention of Micro and Macrovascular Complications
Authors: Barros Armando Lira , Silva Ana Kallynne de Araújo , Rangel Raiana Santos Chaves , Nascimento Ariele Renata Rodrigues , Gomes Caroline de Oliveira , Ramos Yasmin Bandeira , Tonial Maria Fernanda Haas , Bezerra Lucas Paulo , Oliveira Maria Fernanda Seixas , Oliveira Rebecca Maria Gomes , Carvalho Maria Gabriella Simas Aranha Teixeira de , Mafra Luiza Carmita Assunção , Sarmento Ana Carolina Gadelha , Medeiros José Vinícius Avelino de , Passos Marina de Queiroz , Trigueiro Júlia Emerenciano de Albuquerque Melo , Ramos Fernanda Luiza Soares , Costa Luiz Eduardo Staufackar Carlos , Alves Brenda Chaves , Rodrigues André Jereissati Melo , Moreira Filipe da Nóbrega Tomaz , Brito Artur Freire , Saldanha Luciano Victor Vasconcelos , Ramos Caio Gabriel Rocha , Souza José Lucas Silva de , Souza Paulo Mateus Barreto de , Sentinella Maurício Aparecido Terrani 
Published: February 2025

Objective: This study aims to systematically and quantitatively analyze the impact of intensive clinical management of cardiovascular risk factors in patients with Type 1 Diabetes Mellitus (T1DM), focusing on the prevention of micro and macrovascular complications.

Theoretical Framework: T1DM is an autoimmune disease associated with a high risk of vascular complications that significantly affect patients' quality of life and clinical outcomes. Intensive management strategies, including strict glycemic control, lifestyle modifications, and comorbidity treatment, have demonstrated efficacy in reducing adverse events. However, gaps remain regarding the durability of these benefits and the need for personalized approaches for different patient profiles.

Method: A systematic review was conducted using the PubMed, Scopus, and Web of Science databases, including studies published between 2015 and 2024. The inclusion criteria encompassed research evaluating the reduction of vascular complications, functional outcomes, efficacy of intensive management, and safety. The exclusion criteria eliminated studies without interventions related to cardiovascular risk factors or those without relevant outcome measures.

Results and Discussion: The findings indicate that intensive clinical management significantly reduces the incidence of micro and macrovascular complications, such as nephropathy, retinopathy, and cardiovascular events, particularly when combined with behavioral changes. However, treatment response varies according to factors such as age, disease duration, and genetic profile. Multidisciplinary strategies and personalized interventions emerge as the most effective approaches to optimize outcomes and minimize risks.
Research Implications: This study reinforces the importance of long-term and multicenter clinical trials to establish standardized protocols and assess the efficacy and safety of intensive management. Future research should explore cost-effectiveness and the impact on patients' quality of life.

Originality/Value: This systematic review provides valuable evidence on the efficacy of intensive clinical management in controlling cardiovascular risk factors in patients with T1DM, contributing to more informed clinical decisions and better patient outcomes. The results highlight the relevance of individualized strategies in treating patients with T1DM and a high risk of vascular complications.