bluuebunny/crossref_metadata_2025_split huggingface dataset:
Client-centered detached modular housing: natural language processing-enabled design recommender system
Authors: Kim Inhan , Shin Jihye , Shah Syed Haseeb , Rehman Saddiq Ur 
Published: April 2024

AbstractDesigning modular housing is a complex task that necessitates a thorough understanding of the diverse needs of clients in terms of both design aesthetics and floor plan layout. Furthermore, adhering to design for manufacture and assembly (DfMA) principles adds to the complexity, as these are essential modular home requirements. Traditional construction methods frequently fail to meet the specific needs of both clients and DfMA, potentially resulting in suboptimal design solutions. Incorporating client requirements during the design phase necessitates the use of an effective system and framework to reduce changes in subsequent project stages. Existing literature lacks a suitable approach, particularly in the context of modular housing. To address this gap, this paper introduces an artificial intelligence–building information modeling recommender system (RS) for detached modular housing design. The system processes client requirements entered as text utilizing the Word2vec algorithm with the GloVe dataset, refined through transfer learning using surveyed client data of housing needs. The system recommends three distinct modular building design alternatives sourced from a building information modeling models database using cosine and Euclidean similarity functions. A sensitivity analysis ensures that client needs are considered fairly, increasing the robustness of the RS. By incorporating natural language processing, this system transforms the construction industry by making initial designs more client-centric compared with traditional methods. Furthermore, it promotes improved collaboration among clients, design, and construction teams, reducing modifications to design in later stages of construction.
Availability and utilization of molecular testing for primary central nervous system tumors among US hospitals
Authors: Parker Megan , Kazemi Foad , Krishnakumar Asha , Horowitz Melanie A , Myneni Saket , Liu Abby , Schreck Karisa C , Lucas Calixto-Hope G , Mukherjee Debraj 
Published: April 2024

Abstract
Advanced molecular testing has increasingly become an integral component for accurate diagnosis of central nervous system (CNS) tumors. We sought to establish the current state of molecular testing availability and approaches for the diagnosis of CNS tumors in US hospitals that conduct high volumes of CNS tumor resections. We distributed a 16-item survey inquiring about molecular testing approaches for CNS tumors to 115 neuropathologists at US hospitals with neurosurgery residency programs. Thirty-five neuropathologists (30.4%) responded to the survey, all of whom indicated their institutions perform molecular testing on CNS tumor tissue. The most commonly offered tests were MGMT methylation profiling and next-generation sequencing. Fourteen respondents (40%) indicated that their institution is able to test for and report all of the molecular alterations included in our survey. Nine (25.7%) respondents indicated that molecular testing is performed as standard of care for all patients with resected CNS tumors. Our results suggest that even in academic hospitals with a high volume of CNS tumor resections, molecular testing for these tumors is limited. Continued initiatives are necessary to expand the availability of molecular testing for CNS tumors to ensure diagnostic accuracy and guide targeted therapy.
SMARCA4-deficient central nervous system metastases: A case series and systematic review
Authors: Morris Meaghan , Ararat Kerime , Cutshall Hannah , Gokden Murat , Rodriguez Analiz , Rooper Lisa , Lindberg Matthew , Nix James Stephen 
Published: April 2024

AbstractSMARCA4 alterations can be encountered in a variety of human neoplasms, and metastases to the central nervous system (CNS) are rare, offering a challenge to neuropathologists despite not representing a distinct diagnostic entity. To better understand the clinical and histologic presentation of such neoplasms, we report an observational case series and systematic review of 178 unique articles that yielded 15 published cases and 7 cases from institutional files. In the systematic review, the median age was 58 years, the male-to-female ratio was 2:1, and the most common diagnosis was lung adenocarcinoma; all CNS metastases were discovered within 1 year of presentation. In the case series, the median age was 58 years, the male-to-female ratio was 6:1, and all known metastases originated from the lung. Most patients had a smoking history and died of disease. GATA-3 positivity was seen in most case series examples. Concurrent TP53 mutations (83.3%) and a high tumor mutation rate (60%) were common. To our knowledge, this is the only case series and systematic review in the English literature aimed at assessing SMARCA4-altered metastases in the CNS and vertebral column. We highlight the challenges of neuropathologic evaluation of such tumors and provide observational evidence of early metastases, histologic appearances, and immunohistochemical findings, including previously unreported GATA-3 positivity.
The genus Oxytropis DC: application, phytochemistry, pharmacology, and toxicity
Authors: Wang Bingkang , Tian Zhenhua , Lang Shiyue , Kong Qinghe , Liu Xue , Chen Yueru , Hua Min , Zhou Qian , Yu Xiaofei , Feng Hao , Wang Fulin , Zhou Honglei 
Published: April 2024

Abstract

Objectives
Oxytropis DC is a perennial plant of Fabaceae family, which is widely distributed in the northern temperate zone. It is known as “locoweed” because of its toxic component swainsonine. However, it is widely used in Tibetan medicine and Mongolian medicine, mainly for the treatment of heat-clearing and detoxifying, pain-relieving, anti-inflammatory, hemostasis, and other diseases. To provide a basis for the further development and utilization of Oxytropis DC, the pieces of literature about the application, phytochemistry, pharmacological action, and toxicity of Oxytropis DC were reviewed and analyzed.

Key findings
A total of 373 chemical constituents were found from Oxytropis DC, including flavonoids, alkaloids, steroids, terpenoids, and others. Pharmacological actions mainly include antitumor, antioxidation, anti-inflammatory, analgesic, antibacterial, antifibrosis, and other pharmacological actions, among them, the antitumor effect is particularly prominent.

Summary
At present, studies on its pharmacological effects are mainly concentrated on the extracts, some flavonoids, and alkaloids. In the follow-up studies, research on the pharmacological activities of the other chemical constituents in Oxytropis should be strengthened. It has the potential to pave the way for research and development of novel Oxytropis medicines.
Bactericidal effect of bacteria isolated from the marine sponges Hymeniacidon perlevis and Halichondria panicea against carbapenem-resistant Acinetobacter baumannii
Authors: Rodriguez Jimenez Ana , Breine Anke , Whiteway Clemence , Dechamps Etienne , George Isabelle F , Van der Henst Charles 
Published: April 2024

Abstract
In this study, we evaluated the antimicrobial activity of bacteria isolated from the marine sponges Hymeniacidon perlevis and Halichondria panicea against seven Acinetobacter baumannii strains, the majority of which were clinically relevant carbapenem-resistant A. baumannii strains. We observed the inhibitory activity of 18 (out of 114) sponge-isolated bacterial strains against all A. baumannii strains using medium-throughput solid agar overlay assays. These inhibitory strains belonged to the genera Lactococcus, Pseudomonas, and Vagococcus. In addition, this antimicrobial activity was validated through a liquid co-cultivation challenge using an inhibitory strain of each genus and a green fluorescent protein-tagged A. baumannii strain. Fluorescence measurements indicated that the growth of A. baumannii was inhibited by the sponge isolates. In addition, the inability of A. baumannii to grow after spreading the co-cultures on solid medium allowed us to characterize the activity of the sponge isolates as bactericidal. In conclusion, this study demonstrates that marine sponges are a reservoir of bacteria that deserves to be tapped for antibiotic discovery against A. baumannii.
Rising rates of paracoccidioidomycosis-related hospitalizations and in-hospital deaths, Rio de Janeiro, Brazil (2010–2019)
Authors: Falcão Eduardo Mastrangelo Marinho , de Macedo Priscila Marques , Coutinho Ziadir Francisco , Bastos Francisco Inacio , do Valle Antonio Carlos Francesconi 
Published: April 2024

Abstract
The epidemiological dynamics of paracoccidioidomycosis (PCM) has been changing over the years. We analyzed secondary public data from the Hospital Information System of the Brazilian Unified Health System (SIH/SUS), focusing on PCM-related hospitalizations and in-hospital deaths. In the period between 2010 and 2019, 396 hospitalizations and 30 deaths were related to PCM among 7 073 334 hospitalizations registered in Rio de Janeiro. We highlight the rising rates, reflecting the increase in the number of acute forms previously reported. Urgent public health policies are essential to prevent poor outcomes related to this neglected mycosis.
RING 4.0: faster residue interaction networks with novel interaction types across over 35,000 different chemical structures
Authors: Del Conte Alessio , Camagni Giorgia F , Clementel Damiano , Minervini Giovanni , Monzon Alexander Miguel , Ferrari Carlo , Piovesan Damiano , Tosatto Silvio C E 
Published: April 2024

Abstract
Residue interaction networks (RINs) are a valuable approach for representing contacts in protein structures. RINs have been widely used in various research areas, including the analysis of mutation effects, domain-domain communication, catalytic activity, and molecular dynamics simulations. The RING server is a powerful tool to calculate non-covalent molecular interactions based on geometrical parameters, providing high-quality and reliable results. Here, we introduce RING 4.0, which includes significant enhancements for identifying both covalent and non-covalent bonds in protein structures. It now encompasses seven different interaction types, with the addition of π-hydrogen, halogen bonds and metal ion coordination sites. The definitions of all available bond types have also been refined and RING can now process the complete PDB chemical component dictionary (over 35000 different molecules) which provides atom names and covalent connectivity information for all known ligands. Optimization of the software has improved execution time by an order of magnitude. The RING web server has been redesigned to provide a more engaging and interactive user experience, incorporating new visualization tools. Users can now visualize all types of interactions simultaneously in the structure viewer and network component. The web server, including extensive help and tutorials, is available from URL: https://ring.biocomputingup.it/.
From the gut to the brain: the long journey of phenolic compounds with neurocognitive effects
Authors: Domínguez-López Inés , López-Yerena Anallely , Vallverdú-Queralt Anna , Pallàs Mercè , Lamuela-Raventós Rosa M , Pérez Maria 
Published: April 2024

Abstract
The human gut microbiota is a complex community of micro-organisms that play a crucial role in maintaining overall health. Recent research has shown that gut microbes also have a profound impact on brain function and cognition, leading to the concept of the gut–brain axis. One way in which the gut microbiota can influence the brain is through the bioconversion of polyphenols to other bioactive molecules. Phenolic compounds are a group of natural plant metabolites widely available in the human diet, which have anti-inflammatory and other positive effects on health. Recent studies have also suggested that some gut microbiota–derived phenolic metabolites may have neurocognitive effects, such as improving memory and cognitive function. The specific mechanisms involved are still being studied, but it is believed that phenolic metabolites may modulate neurotransmitter signaling, reduce inflammation, and enhance neural plasticity. Therefore, to exert a protective effect on neurocognition, dietary polyphenols or their metabolites must reach the brain, or act indirectly by producing an increase in bioactive molecules such as neurotransmitters. Once ingested, phenolic compounds are subjected to various processes (eg, metabolization by gut microbiota, absorption, distribution) before they cross the blood–brain barrier, perhaps the most challenging stage of their trajectory. Understanding the role of phenolic compounds in the gut–brain axis has important implications for the development of new therapeutic strategies for neurological and psychiatric disorders. By targeting the gut microbiota and its production of phenolic metabolites, it may be possible to improve brain function and prevent cognitive decline. In this article, the current state of knowledge on the endogenous generation of phenolic metabolites by the gut microbiota and how these compounds can reach the brain and exert neurocognitive effects was reviewed.
The Perils of Occupation
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
As McClellan was driven off the Peninsula in Virginia, dramas of deliverance played out in Tennessee, Louisiana, and Maryland. Andrew Johnson and Benjamin Butler, installed as occupiers in Nashville and New Orleans, learned the hard way that white Southerners would not follow their script, and that elite women in particular scorned Federal “protection.” Hoping to press his advantage, Lee for his part set his sights on Maryland, determined to disenthrall it from the Yankee yoke, only to have Marylanders turn their backs on his army. A new standard for battlefield horror was set on September 17, 1862, at Antietam Creek, near Sharpsburg, Maryland, where the two armies inflicted 23,000 casualties in twelve hours of savage combat, making it the bloodiest single day in American history. For Union soldiers and the Northern public, Antietam furnished yet more proof of the power that falsehood and despotism exerted over the Confederates. For Lincoln, Antietam was an “indication of Divine will,” as he told his cabinet—a sign that “it was his duty to move forward in the cause of emancipation.”
Fire in the Rear
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
In March 1863 the Milwaukee Sentinel published a revealing letter from a soldier in the 66th Illinois Volunteers (also known as the “Western Sharpshooters”) who was manning a stockade near Corinth, Mississippi. “Another year of victories for us, and the C.S.A. will pass away ‘and there will be a new heaven and a new earth,’ ” the correspondent predicted. He professed his great faith both in Lincoln’s “saving ordinance” of emancipation and in white Southern Unionism. “Refugees come to our lines frequently seeking protection from the power of Davis, the Southern tyrant and dictator,” he observed, noting that none other than the Honorable John W. Wood, one of only two delegates to the Mississippi secession convention to reject secession, was among the recently arrived refugees. “He is now in our camp and tells many wonderful tales of tyranny, oppression, suffering in the South. He states that even the most sanguine supporters of rebellion have no faith in their ultimate success and their only hope seems to be derived from expectations of foreign intervention of a division of the North,” the letter explained. “The treasury is without credit and many poor families are starving throughout the country.
Under a Scorching Sun
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
“A few hot-headed demagogues have dragged the State of Virginia almost into beggary and turned their once beautiful country into a desert,” Private John Haley lamented to his diary on June 15, 1863, as the Army of the Potomac geared up to take on Robert E. Lee again. “There was never anything so near akin to despotism in this country as is now being enacted in the so-called Southern Confederacy.” A week later, Philip Hamlin of the 1st Minnesota struck a similar chord in a letter home. Deploring how the Old Dominion had been “marred by the hand of war,” he added that no state “possesses more numerous or varied resources than Virginia and it would be a glorious sight to see a young and free civilization springing up here where slavery has wrought ruin.” Haley, a millworker from Saco, Maine, who joined his regiment in August 1862, at age twenty-two, had fought at Fredericksburg and Chancellorsville.
Malice Toward None
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
“It will be impossible for me to send sufficient troops from this army to oppose Sherman’s and at the same time resist Grant,” Robert E. Lee wrote Confederate congressman William Porcher Miles of South Carolina on January 19, 1865, in response to requests that Lee’s men rally to the defense of Charleston. “If the people in South Carolina & Georgia would turn out in all their strength,” Lee advised, “the advance of Sherman ought to be checked.” A month later, Charleston fell at last to Federal forces, in the culmination of siege operations on its harbor defense that dated back to July 1863.
Conclusion
Authors: Varon Elizabeth R 
Published: April 2024

Abstract
On September 30, 1865, Kentucky Unionist Robert J. Breckinridge gave an address at Union College in upstate New York entitled “The Great Deliverance and the New Career.” The address reprised themes Breckinridge had developed in countless speeches over the course of the war: the argument that the Southern masses had been deluded and misled into treason by scheming conspirators; that the Confederacy had been a “relentless military despotism”; that emancipation was a military necessity for defeating the rebellion; that Lincoln had shown Americans the path of righteousness; and that America, delivered from the scourge of war, was poised to fulfill her destiny of greatness. In Breckinridge’s view, the mutual duties of the vanquished and the victors were clear. Confederates must “accept the overthrow of their insurrection as an everlasting finality.” The victors must be careful not “to wound, to exasperate, to afflict, nor even to punish” the Southern masses but instead must “accept their restoration as fully and completely as we require them to renounce their hostility.”
Inevitable Resistance
Authors: Barrett Ron , Zuckerman Molly K. , Dudgeon Matthew R. , Armelagos George J. 
Published: April 2024

Abstract
Pathogens are evolving drug resistance at a faster rate than humans can develop new medicines. At these rates, it is quite possible that the human species may be moving toward a post-antimicrobial era. This chapter begins by examining the evolution of antibiosis and its countermeasures as well as the parallel histories of antimicrobial drug development among human hosts and the accelerated evolution of antimicrobial resistance among pathogens. The latter trends are certainly driven by prescription and consumption practices, which are further challenged by issues of aging and poverty. However, the rise of resistance is even more impacted by the misuse of these drugs as growth factors in commercial agriculture. At the level of international policy, a One Health approach may help to mitigate the problem or possibly reverse these trends. Examples include MRSA, malaria, VRSE, and MDR/XDRTB as well as lessons drawn from the history of smallpox vaccination.
Prologue
Authors: Baggott Jim , Heilbron John L. 
Published: April 2024

Abstract
Our drama deals with the distinctly human compulsion to divide the world into domains of experience, like religion and physics, defined by rules and expectations. Fundamentalists pursue the illusory goal of a final theory of everything belonging to a domain. Their aim is closure – to declare that no plausible alternatives are possible. Neils Bohr sought to close the domain of quantum mechanics within a few years of its discovery. Albert Einstein objected to this hasty surrender of the possibility of alternatives more in keeping with classical intuition. Bohr’s efforts to achieve closure in the face of Einstein’s attempts to prise it open framed one of the most dramatic debates of twentieth-century science, and led to experimental discoveries that deepened the mystery and may yet profoundly impact our lives.
New Ways to Calculate
Authors: Baggott Jim , Heilbron John L. 
Published: April 2024

Abstract
In June 1925 Heisenberg made the breakthrough that would lead to matrix mechanics. The theory was abstract, offered no means for visualizing the mechanics of the atom, and its application required a lot of heavy lifting. Erwin Schrödinger subsequently made the breakthrough that would lead to wave mechanics, building on Louis de Broglie’s association of a wave with an electron. In Schrödinger’s wave equation the quantum numbers of the hydrogen atom arise naturally. He argued that his ‘wavefunction’ offered a realistic description of the electron in an atom, and sought to eliminate Bohr’s discontinuous quantum jumps. But in the spring of 1926, Max Born offered an enduring alternative. The modulus-square of the wavefunction is a measure of probability in an unvisualizable microphysics. In an intense debate with Bohr, Schrödinger demanded a theory based on logical concepts free from contradictions. Bohr was left to ponder what this might mean.
Incompatible Conceptions
Authors: Baggott Jim , Heilbron John L. 
Published: April 2024

Abstract
Einstein was not in the audience at Bohr’s Como lecture, and their debate was joined in earnest at the fifth Solvay conference in Brussels in October 1927. All of quantum theory’s founders were present. Einstein excused himself for not having mastered the theory, and introduced a simple electron diffraction thought experiment for which he offered two conceptions. In the first, the wavefunction does not describe individual events and is purely statistical. In the second, the wavefunction does describe individual events, its modulus-square giving the probability of detecting the next diffracted electron at a specific position. In his view, the second conception could not stand, as it implies a ‘very peculiar mechanism of action at a distance’. Outside the conference room Einstein peppered Bohr with thought experiments devised to reveal the theory’s confusions or contradictions. The exchanges between them went on like a game of chess, with Bohr emerging the victor.
Postwar Hostilities
Authors: Baggott Jim , Heilbron John L. 
Published: April 2024

Abstract
World War II drove several of the founders to Britain or the US. Foundational questions returned with renewed energy in the early postwar years when significant anniversaries came due. The usual suspects rejoined the debate. In the volume celebrating his 70th birthday, Einstein returned to the EPR paper. To its main point, which had been ‘buried alive, so to speak, by erudition’, he now brought exceptional clarity. If the two entangled particles are considered separable and ‘locally real’, then they must communicate via some peculiar mechanism of action at a distance. If they cannot be considered as separable a gaping explanatory hole opens. Either way, quantum theory is not up to the task. But the world of physics, now dominated by America, had moved on. Physicists ‘had no interest in understanding Bohr, and thought that Einstein’s distaste for [quantum mechanics] was just silly . . . It was a very unphilosophical time’.