bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Job Passion on Innovative Work Behaviors: Analytical Research in the Ministry of Higher Education and Scientific Research
Authors: Ghafil Jawad Al Issawi Hasan , Hassoon AlTaee Ali 
Published: April 2024

The current research aims to test the impact of Job passion on innovative work behaviors, and the idea of the research revolves around providing a job passion that contributes and supports the innovative work behaviors among the employees of the Ministry of Higher Education and Scientific Research, as the job passion variable includes four dimensions (enjoyment at work, self-motivation, self-identity, and a sense of learning). The innovative work behavior variable has addressed four dimensions (the ability to provide creative solutions to problems, the ability to new ideas and proposals, the ability to change as well as initiate, and the spirit of risk), A sample of the employees of the Ministry of Higher Education and Scientific Research, where a random stratified sample of 328 employees were selected from the study community (2229) relied on the questionnaire for collecting data, and the questionnaires valid for statistical analysis were 322 questionnaires. The research used a number of statistical methods to obtain the results of the questionnaire, especially the simple correlation coefficient (Pearson) and descriptive analysis methods using the SPSS.v23 and AMOS.v23). It has proved the validity of the hypotheses through which a set of results were reached, the most prominent of which is the existence of a relationship between the impact of job passion and its dimensions on innovative work behaviors. The dimensions of the variable of innovative work behaviors above are available, but they do not be at the required level, where the ability to change and generate creative solutions. This requires focusing on them in addressing problems and making appropriate decisions that are based on a correct scientific basis, and the management's view of employees is not limited because they represent essential capabilities and tools for implementing decisions and policies.
Paper type: Research paper.
Life Function Analysis of a Two-Parameter Exponential Distribution Using Robust Rank Regression
Authors: Samad Sedeeq* Bekhal 
Published: April 2024

In this research, a proposed method is presented to estimate the life function of the two-parameter exponential distribution by using the robust rank regression on the dependent variable, which depends on the robust variance-covariance matrix (the FMCD and OGK method) and the robust mean vector through which the rank regression coefficients are estimated using the method of ordinary least squares and employing it in estimating the scale and location parameters of the exponential distribution and thus analyzing the life function on its basis. A comparison was also made between the proposed method and the classical method of rank regression on the dependent variable of life data at different sample sizes (from 10 to 25) to show the efficiency of the proposed method based on the mean square error of the estimated parameters, through a program prepared by the researcher in MATLAB language dedicated to this purpose. The practical application results concluded that the proposed robust method of rank regression on the dependent variable in estimating the parameters of the exponential distribution was more efficient than the classical method.

Paper type: Research paper.
The Role Of Innovative Marketing In Enhancing Creativity Of Industrial Organizations
Authors: Ahmed Khalf Ghfran , Mohammad Ali Shifaa 
Published: April 2024

Innovative marketing has become a basic pillar that countries and industrial companies rely on to achieve creativity in their work, a true criterion for their success and failure, and an essential element for their profit or loss. Innovative marketing has become an urgent necessity and there is no way to ignore it, because of its vital therefore, industrial organizations must shift from traditional marketing to innovative marketing and think outside traditional frameworks by constantly keeping pace with development, encouraging innovation, generating modern ideas, and adopting the concept of creativity by following modern and innovative marketing means and methods based on distinction and superiority. Hence, this search aimed to know the influence of innovative marketing in developing creativity. Data were collected using a questionnaire survey. The questionnaire form was distributed to a sample of 84 employees at the General Company for Textile and Leather Industry, in addition to personal interviews conducted by the researchers. The study results indicated that there is a relationship between innovative marketing in developing creativity through the selected dimensions, as the company’s management seeks to provide better sustainable programs for developing creativity by enhancing activities related to understanding customers’ desires and providing more of those desires.

Paper type: Analytical research.
IDENTIFICATION OF CHANGES IN LAND USE IN THE KALASAN DISTRICT WITH A SPATIAL APPROACH
Authors: Mali Maria Gloria De Aroyo Tania , Kurniawati Amithya Irma , Ragil Candra 
Published: April 2024

Abstract - Land use change is the change from the previous land use function to another function, one of which is the change from agricultural land to non-agricultural land. Land use change in Kapanewon Kalasan is driven by various community activities. This is due to the rapid population growth and the location of Kapanewong Kalasan, which is the center of crowds near Yogyakarta city. It is in Central Java and is traversed by the Yogyakarta-Surakarta road. The purpose of the study on land use change in Kapanewon Kalasan by spatial approach is to (1) identify land use change from 2010 to 2020, and (2) identify land use change based on the type of spatial approach for a specific time. The research method is a quantitative method by used spatial process analysis with the overlay technique on ArcGIS ArcGIS. The findings show that over the past decade, Kapanewon Kalasan land use increased by 78.1%, land use designated for dry farming increased by 23.1%, paddy field use increased by 90.5%. Overlay results show that many agricultural drylands are being converted to paddy fields and residential areas, thus the increase in agricultural dryland use is small.
Keywords: Land use change, Spatial approach, Spatial process analysis, ArcGis, Overlays
Injectable temperature-sensitive hydrogel facilitating endoscopic submucosal dissection
Authors: Xu Ruifen , Yang Xiaoyu , Yi Tong , Tan Tao , Li Zhongqi , Feng Xuyang , Rao Jing , Zhou Pinghong , Hu Hao , Zhan Yonghua 
Published: April 2024

Purpose: Early gastrointestinal tumors can be removed by endoscopic procedures. Endoscopic mucosal dissection (ESD) requires submucosal fluid injection to provide mucosal elevation and prevent intraoperative perforation. However, the clinically applied normal saline mucosal elevation height is low for a short time, which often requires multiple intraoperative injections that increase the inconvenience and procedure time. In addition, recently researched submucosal injection materials (SIM) suffer from complex preparation, poor economy, and poor biocompatibility. Therefore, there is an urgent need for a new type of SIM that can provide long, safe and effective mucosal elevation in support of the endoscopic procedures.Methods: The FS hydrogel is based on polyethylene-polypropylene glycol (F-127) mixed with sodium alginate (SA). The different physicochemical properties of FS hydrogels were characterized through various experiments. Afterward, various biosafety assessments were carried out. Finally, the performance of FS hydrogels was evaluated by in vitro submucosal injection and in vivo swine ESD.Results: The experimental results show that the FS hydrogel is liquid at room temperature, making it easy to inject, and when injected under the mucosa, it undergoes temperature-induced cross-linking, transforming from a liquid to a solid state to provide long-lasting mucosal augmentation. At the same time, the FS hydrogel exhibits controllable gelation, stability, and biocompatibility. The results of in vitro submucosal injections and in vivo ESD procedures showed that FS achieves high mucosal augmentation and provides good submucosal cushioning in the long term.Conclusion: In summary, the F-127/SA hydrogel is simple to synthesize, cost-effective, safe, easy to store, and able to assist ESD well from the perspective of practical clinical problems, indicating that the FS hydrogel can be an ideal potent submucosal injection substitution.
Evaluation of IFNAR2 and TYK2 transcripts’ prognostic role in COVID-19 patients: a retrospective study
Authors: Razavi Alireza , Raei Maedeh , Hatami Yasin , Chokami Ghazal Saghi , Goudarzi Yasaman , Ghasemian Roya , Alizadeh-Navaei Reza , Yarmohammadi Hossein , Soltanipur Masood , Tabarestani Mohammad , Valadan Reza , Meshkinfam Haghighi Faranak , Tarsi Abbas Khonakdar , Razavi Bahar 
Published: April 2024

Background and objectivesThis study aimed to investigate the possible prognostic significance of interferon alpha–beta receptor subunit 2 (IFNAR2) and tyrosine kinase 2 (TYK2) expressions.MethodsWe conducted a retrospective study including COVID-19 adult patients. All blood samples were collected before any interventions. The expressions of IFNAR2 and TYK2 were assessed using real-time PCR in venous blood samples of 54 cases and 56 controls. The transcript quantities of IFNAR2 and TYK2 genes were assessed using a Delta-Ct method.ResultsOur findings show no significant differences in gene expression levels for IFNAR2 and TYK2 between patients who required oxygen (O2) therapy and those who did not (p-value = 0.732 and p-value = 0.629, respectively). Likewise, there were no significant differences in IFNAR2 and TYK2 expressions between patients hospitalized for less than 7 days and those hospitalized for 7 days or more (p-value = 0.455 and p-value = 0.626, respectively). We also observed a weak correlation between IFNAR2 expression and CRP (p-value = 0.045, r = 0.192). There was a negative correlation between the expression levels of IFNAR2 and TYK2 transcripts in COVID-19 patients (p-value = 0.044; partial correlation coefficient = -0.283). Additionally, IFNAR2 and TYK2 were significantly downregulated in the COVID-19 group compared to healthy subjects (p-value = 0.002 and p-value = 0.028, respectively). However, neither IFNAR2 nor TYK2 expression was significantly different between the case subgroups based on COVID-19 severity. The IFNAR2 ΔΔCt (B = -0.184, 95% CI: -0.524–0.157, p-value = 0.275) and the TYK2 ΔΔCt (B = 0.114, 95% CI: -0.268–0.496, p-value = 0.543) were not found to be significant predictors of hospitalization duration. The area under the curve (AUC) for IFNAR2 expression is 0.655 (p-value = 0.005, 95% CI: 0.554–0.757), suggesting its poor discriminative value.ConclusionWe were unable to comment definitively on the prognostic power of IFNAR2 and TYK2 expressions in COVID-19 patients, and larger-scale studies are needed. The principal limitations of this study included the lack of longitudinal analysis and limited sample size.
Hesperidin alleviates zinc-induced nephrotoxicity via the gut-kidney axis in swine
Authors: Yang Qingwen , Qian Lv , He Shanshan , Zhang Chuanshi 
Published: April 2024

IntroductionZinc (Zn) is an essential trace element in animals, but excessive intake can lead to renal toxicity damage. Thus, the exploration of effective natural antagonists to reduce the toxicity caused by Zn has become a major scientific problem.MethodsHere, we found that hesperidin could effectively alleviate the renal toxicity induced by Zn in pigs by using hematoxylin-eosin staining, transmission electron microscope, immunohistochemistry, fluorescence quantitative PCR, and microfloral DNA sequencing.ResultsThe results showed that hesperidin could effectively attenuate the pathological injury in kidney, and reduce autophagy and apoptosis induced by Zn, which evidenced by the downregulation of LC3, ATG5, Bak1, Bax, Caspase-3 and upregulation of p62 and Bcl2. Additionally, hesperidin could reverse colon injury and the decrease of ZO-1 protein expression. Interestingly, hesperidin restored the intestinal flora structure disturbed by Zn, and significantly reduced the abundance of Tenericutes (phylum level) and Christensenella (genus level).DiscussionThus, altered intestinal flora and intestinal barrier function constitute the gut-kidney axis, which is involved in hesperidin alleviating Zn-induced nephrotoxicity. Our study provides theoretical basis and practical significance of hesperidin for the prevention and treatment of Zn-induced nephrotoxicity through gut-kidney axis.
Evaluating the relative importance of different blood pressure indices in screening for NAFLD: a survey report based on a health examination population
Authors: Hu Chong , Yu Ziqi , Wei Changli , Sheng Guotai , Chen Jianyong , Zou Yang 
Published: April 2024

ObjectiveWhile hypertension is a well-recognized risk factor for non-alcoholic fatty liver disease (NAFLD), the specific roles of various common blood pressure measurements [diastolic blood pressure (DBP), systolic blood pressure (SBP), pulse pressure (PP), mean arterial pressure (MAP)] in detecting NAFLD and evaluating the associated risk in adults remain unclear.MethodsA retrospective analysis was conducted on 14,251 adult participants undergoing health screenings in the NAfld in the Gifu Area, Longitudinal Analysis project (NAGALA). Following the Z-transformation of the independent variables, we evaluated the relationships between the four blood pressure indices and NAFLD through multivariable logistic regression models. This analysis documented the odds ratio (OR) and 95% confidence interval (CI) for each standard deviation (SD) increase. Additionally, the effectiveness of these indices in identifying NAFLD was comparatively analyzed using receiver operating characteristic (ROC) curves.ResultsAfter adequately adjusting for confounders, all blood pressure indices except PP showed a positive correlation with NAFLD. For each SD increment, MAP had the strongest association with NAFLD compared to SBP and DBP. This finding was confirmed in populations without exercise habits, under 60 years of age, with normal blood pressure, and in non-obese groups. Furthermore, based on ROC analysis, MAP was found to have the highest accuracy in identifying NAFLD compared to the other three blood pressure indices.ConclusionAmong the four blood pressure indices evaluated, MAP demonstrates the greatest efficacy in identifying NAFLD and assessing its associated risk. These findings underscore the potential of MAP as the most promising blood pressure index for screening NAFLD.
Venous thromboembolism and severe COVID-19: a Mendelian randomization trial and transcriptomic analysis
Authors: Chen Liang , Dai Xiaoting 
Published: April 2024

IntroductionVenous thromboembolism (VTE) is known to be intricately linked to severe COVID-19 (sCOVID-19) occurrence. Herein, we employed univariable Mendelian randomization (MR) and transcriptome analysis to predict the causal association and associated signaling networks between VTE and sCOVID-19.MethodsPotential VTE and sCOVID-19 association was assessed using MR-Egger, weighted median, simple mode, weighted mode, and inverse variance weighted (IVW) regression. We conducted independent univariable analyses involving VTE and sCOVID-19. Using heterogeneity, pleiotropy, and the Leave-One-Out examinations, we performed sensitivity analyses. Thereafter, we performed transcriptome analysis of the GSE164805 dataset to identify differentially expressed genes (DEGs) linked to single nucleotide polymorphisms (SNPs). Lastly, we conducted immune analyses.ResultsBased on our univariable analysis, VTE was a strong indicator of sCOVID-19 development, and it was intricately linked to sCOVID-19. We further conducted sensitivity analysis to demonstrate the reliability of our results. Using differential analysis, we identified 15 major genes, namely, ACSS2, CEP250, CYP4V2, DDB2, EIF6, GBGT1, GSS, MADD, MAPK8IP1, MMP24, YBPC3, NT5DC3, PROCR, SURF6, and YIPF2, which were strongly connected to suppressive adaptive immune as well as augmented inflammatory cells. In addition, we uncovered strong associations with most differential immunologic gene sets, such as, the Major Histocompatibility Complex (MHC), immunoactivators, and immunosuppressors.ConclusionHerein, we demonstrated we strong association between VTE and enhanced sCOVID-19 risk. We also identified 15 DEGs which potentially contribute to the shared immunologic pathogenesis between VTE and sCOVID-19.
An inflammation-related subtype classification for analyzing tumor microenvironment and clinical prognosis in colorectal cancer
Authors: Pei Junpeng , Gao Yuye , Wu Aiwen 
Published: April 2024

BackgroundThe inflammatory response plays an essential role in the tumor microenvironment (TME) of colorectal cancer (CRC) by modulating tumor growth, progression, and response to therapy through the recruitment of immune cells, production of cytokines, and activation of signaling pathways. However, the molecular subtypes and risk score prognostic model based on inflammatory response remain to be further explored.MethodsInflammation-related genes were collected from the molecular signature database and molecular subtypes were identified using nonnegative matrix factorization based on the TCGA cohort. We compared the clinicopathological features, immune infiltration, somatic mutation profile, survival prognosis, and drug sensitivity between the subtypes. The risk score model was developed using LASSO and multivariate Cox regression in the TCGA cohort. The above results were independently validated in the GEO cohort. Moreover, we explored the biological functions of the hub gene, receptor interacting protein kinase 2 (RIPK2), leveraging proteomics data, in vivo, and in vitro experiments.ResultsWe identified two inflammation-related subtypes (inflammation-low and inflammation-high) and have excellent internal consistency and stability. Inflammation-high subtype showed higher immune cell infiltration and increased sensitivity to common chemotherapeutic drugs, while inflammation-low subtype may be more suitable for immunotherapy. Besides, the two subtypes differ significantly in pathway enrichment and biological functions. In addition, the 11-gene signature prognostic model constructed from inflammation-related genes showed strong prognostic assessment power and could serve as a novel prognostic marker to predict the survival of CRC patients. Finally, RIPK2 plays a crucial role in promoting malignant proliferation of CRC cell validated by experiment.ConclusionsThis study provides new insights into the heterogeneity of CRC and provides novel opportunities for treatment development and clinical decision making.
Exploring causal correlations between inflammatory cytokines and Ménière’s disease: a Mendelian randomization
Authors: Xie SongTao , Zhang RuoFeng , Tang YuRou , Dai QingQing 
Published: April 2024

ObjectivesPrevious studies have highlighted associations between certain inflammatory cytokines and Ménière’s Disease (MD), such as interleukin (IL) -13 and IL-1β. This Mendelian randomization aims to comprehensively evaluate the causal relationships between 91 inflammatory cytokines and MD.MethodsA comprehensive two-sample Mendelian randomization (MR) analysis was conducted to determine the causal association between inflammatory cytokines and MD. Utilizing publicly accessible genetic datasets, we explored causal links between 91 inflammatory cytokines and MD risk. Comprehensive sensitivity analyses were employed to assess the robustness, heterogeneity, and presence of horizontal pleiotropy in our findings.ResultsOur findings indicate that MD causally influences the levels of two cytokine types: IL-10 (P=0.048, OR=0.945, 95%CI =0.894~1.000) and Neurotrophin-3 (P=0.045, OR=0954, 95%CI =0.910~0.999). Furthermore, three cytokines exhibited significant causal effects on MD: CD40L receptor (P=0.008, OR=0.865, 95%CI =0.777-0.963), Delta and Notch-like epidermal growth factor-related receptor (DNER) (P=0.010, OR=1.216, 95%CI =1.048-1.412), and STAM binding protein (P=0.044, OR=0.776, 95%CI =0.606-0.993).ConclusionThis study suggests that the CD40L receptor, DNER, and STAM binding protein could potentially serve as upstream determinants of MD. Furthermore, our results imply that when MD is regarded as the exposure variable in MR analysis, it may causally correlate with elevated levels of IL-10 and Neurotrophin-3. Using these cytokines for MD diagnosis or as potential therapeutic targets holds great clinical significance.
Comprehensive analysis of human monocyte subsets using full-spectrum flow cytometry and hierarchical marker clustering
Authors: Li Chao , Xiao Maozhi , Geng Suxia , Wang Yulian , Zeng Lingji , Lai Peilong , Gong Ying , Chen Xiaomei 
Published: April 2024

IntroductionExploring monocytes’ roles within the tumor microenvironment is crucial for crafting targeted cancer treatments.MethodsThis study unveils a novel methodology utilizing four 20-color flow cytometry panels for comprehensive peripheral immune system phenotyping, specifically targeting classical, intermediate, and non-classical monocyte subsets. ResultsBy applying advanced dimensionality reduction techniques like t-distributed stochastic neighbor embedding (tSNE) and FlowSom analysis, we performed an extensive profiling of monocytes, assessing 50 unique cell surface markers related to a wide range of immunological functions, including activation, differentiation, and immune checkpoint regulation. DiscussionThis in-depth approach significantly refines the identification of monocyte subsets, directly supporting the development of personalized immunotherapies and enhancing diagnostic precision. Our pioneering panel for monocyte phenotyping marks a substantial leap in understanding monocyte biology, with profound implications for the accuracy of disease diagnostics and the success of checkpoint-inhibitor therapies. Key findings include revealing distinct marker expression patterns linked to tumor progression and providing new avenues for targeted therapeutic interventions.