bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilient forests for the future
Authors: Perry Annika , Aravanopoulos Filippos A. , Budde Katharina Birgit , Hansen Ole Kim , Rellstab Christian , Schroeder Hilke , Curtu Alexandru Lucian 
Published: May 2024

AbstractForest ecosystems are of global importance, ecologically, economically and culturally. However, despite their fundamental role in mitigating the worst effects of climate change, to date there have been surprisingly few resources devoted to defining, conserving and planning resilient forests for the future. Progress in this field of research, which requires international and interdisciplinary cooperation, collaboration and communication, was presented and discussed at the second biannual conference of the European Research Group, Evoltree (https://www.evoltree.eu). Over four days more than 140 scientists met to share developments and to discuss forest ecology, genetics, genomics and evolution with a focus on realising “Resilient Forests for the Future”. From examining evolutionary dynamics and using the past to understand future responses, to evaluating breeding approaches and the sustainable use of forest genetic resources, the conference addressed critical themes with relevance to this topic. The role of genomics in conservation, investigation of biotic interactions and identifying climate resilient forests were also explored. Finally, innovative methods and approaches which promise to increase the scale and speed with which forest evolutionary research can progress were introduced and evaluated. The Evoltree network and conference series provides invaluable opportunities to share knowledge and increase collaboration on forest genetic research, the need for which has never been greater or more urgent.
Systematic underestimation of polycyclic aromatic hydrocarbon aqueous concentrations in rivers
Authors: Zoboli Ottavia , Weber Nikolaus , Braun Katharina , Krampe Jörg , Zessner Matthias 
Published: May 2024

AbstractPolycyclic aromatic hydrocarbons (PAHs) are a widespread group of organic contaminants whose presence in water bodies is cause of severe concern. With few exceptions, the majority of PAHs is hydrophobic, presents a high adsorption affinity, and is thus primarily transported within river systems during high-flow events together with suspended particulate matter (SPM). Evidence exists of analytical challenges related to the incomplete extraction of PAHs adsorbed to solids and thus to a potential negative bias in the chemical analysis of PAHs in bulk water samples with high SPM content. Despite this, partly due to the elevated efforts required to collect representative samples containing sufficient SPM for the separate PAH analysis in this matrix, several investigations rely on the analysis of aqueous samples. This study tests the hypothesis that surveys based exclusively on bulk water may lead to a systematic underestimation of the real contamination level and transport of PAHs in rivers. Six high-turbidity events were examined in three Austrian rivers applying time-integrated sampling and simultaneously analyzing PAHs in total bulk water, filtered water, SPM, and supernatant. Despite an unavoidable degree of uncertainty in such challenging sampling scheme, the results indicate that measurements performed with best available standard methods in bulk water samples determined in average only about 40% of the theoretically expected total PAHs concentrations derived from the analyses in SPM. Such deviation has important implications for the reliable assessment of the compliance with environmental quality standards as well as for surveys aimed to estimate riverine loads, validate emission models, and understand the transport dynamics of PAHs in rivers. Whereas the first objective, e.g., in European countries, is alternatively achieved via monitoring in biota, the latter ones require efforts directed to complement monitoring campaigns with separate sampling of SPM, with monitoring of suspended solids transport to appropriately select and interpret the results of water samples and to improve the chemical analysis of PAHs in bulk water samples with high solids content.
Parental Migration and Fear of Crime Among Left-Behind Children in Rural China
Authors: Qu Jia , Lin Kai 
Published: May 2024

AbstractUtilizing a probability sample of 1,985 middle school students from Guizhou Province, China, this study aims to explore the association between different patterns of parental migration and fear of crime among adolescents in rural China. Nested OLS regression analyses revealed that compared to adolescents who live with both parents, adolescents experiencing dual-parent migration reported a heightened fear of crime. However, adolescents with only their mother or father migrating did not exhibit any difference in fear of crime compared to those who lived with their parents. Being female, younger, having experienced crime victimization, perceiving greater family economic pressure, and perceiving greater neighborhood disorder and weaker collective efficacy also elevated crime fear. Findings from this study highlight the acute vulnerability of adolescents experiencing dual-parent migration and urge more targeted social support for this group.
Assessing agricultural adaptation to changing climatic conditions during the English agricultural revolution (1645–1740)
Authors: Martínez-González José Luis 
Published: May 2024

AbstractThis article examines the impact of climatic variability on the English Agricultural Revolution using Allen’s Nitrogen Hypothesis. While half of the variation in yields can be attributed to nitrogen-fixing plants, better cultivation, and improved seeds, the remainder can be attributed to changing climatic conditions during the relatively cold period from c. 1645–1715 and the subsequent warmer phase. The study finds that farmers made even greater efforts than observed yields during the colder and more humid climate of the second half of the seventeenth century and the early eighteenth. Conversely, increasing temperatures in the following period had a positive effect on agricultural productivity, indicating that farmers' role during this phase have been overrated.
The Role of Sleep in Cardiovascular Disease
Authors: Jaspan Vita N. , Greenberg Garred S. , Parihar Siddhant , Park Christine M. , Somers Virend K. , Shapiro Michael D. , Lavie Carl J. , Virani Salim S. , Slipczuk Leandro 
Published: May 2024

Abstract
Purpose of Review
Sleep is an important component of cardiovascular (CV) health. This review summarizes the complex relationship between sleep and CV disease (CVD). Additionally, we describe the data supporting the treatment of sleep disturbances in preventing and treating CVD.

Recent Findings
Recent guidelines recommend screening for obstructive sleep apnea in patients with atrial fibrillation. New data continues to demonstrate the importance of sleep quality and duration for CV health.

Summary
There is a complex bidirectional relationship between sleep health and CVD. Sleep disturbances have systemic effects that contribute to the development of CVD, including hypertension, coronary artery disease, heart failure, and arrhythmias. Additionally, CVD contributes to the development of sleep disturbances. However, more data are needed to support the role of screening for and treatment of sleep disorders for the prevention of CVD.
Effect of hafnium and molybdenum addition on inclusion characteristics in Co-based dual-phase high-entropy alloys
Authors: Wang Yong , Wang Wei , Park Joo Hyun , Mu Wangzhong 
Published: May 2024

AbstractSpecific grades of high-entropy alloys (HEAs) can provide opportunities for optimizing properties toward high-temperature applications. In this work, the Co-based HEA with a chemical composition of Co47.5Cr30Fe7.5Mn7.5Ni7.5 (at%) was chosen. The refractory metallic elements hafnium (Hf) and molybdenum (Mo) were added in small amounts (1.5at%) because of their well-known positive effects on high-temperature properties. Inclusion characteristics were comprehensively explored by using a two-dimensional cross-sectional method and extracted by using a three-dimensional electrolytic extraction method. The results revealed that the addition of Hf can reduce Al2O3 inclusions and lead to the formation of more stable Hf-rich inclusions as the main phase. Mo addition cannot influence the inclusion type but could influence the inclusion characteristics by affecting the physical parameters of the HEA melt. The calculated coagulation coefficient and collision rate of Al2O3 inclusions were higher than those of HfO2 inclusions, but the inclusion amount played a larger role in the agglomeration behavior of HfO2 and Al2O3 inclusions. The impurity level and active elements in HEAs were the crucial factors affecting inclusion formation.
Advances in the molecular regulation mechanism of tumor dormancy and its therapeutic strategy
Authors: Wang Yuan , Wang Linlin , Wei Yaojun , Wei Chuang , Yang Haohang , Chen Qiurui , Zhang Rongxin , Shen Han 
Published: May 2024

AbstractTumor dormancy is a stage in the growth and development of malignant cells and is one of the biological characteristics of malignant cells. Complex transitions involving dormant tumor cells between quiescent and proliferative states pose challenges for tumor eradication. This paper explores the biological features and molecular mechanisms of tumor dormancy and highlights emerging therapies. The strategies discussed promise innovative clinical potential against malignant tumors. Understanding the mechanisms of dormancy can help provide valuable insights into the diagnosis and treatment of malignant tumors to advance the fight against this world problem.
Unraveling progression subtypes in people with Huntington’s disease
Authors: Raschka Tamara , Li Zexin , Gaßner Heiko , Kohl Zacharias , Jukic Jelena , Marxreiter Franz , Fröhlich Holger 
Published: May 2024

Abstract
Background
Huntington’s disease (HD) is a progressive neurodegenerative disease caused by a CAG trinucleotide expansion in the huntingtin gene. The length of the CAG repeat is inversely correlated with disease onset. HD is characterized by hyperkinetic movement disorder, psychiatric symptoms, and cognitive deficits, which greatly impact patient’s quality of life. Despite this clear genetic course, high variability of HD patients’ symptoms can be observed. Current clinical diagnosis of HD solely relies on the presence of motor signs, disregarding the other important aspects of the disease. By incorporating a broader approach that encompasses motor as well as non-motor aspects of HD, predictive, preventive, and personalized (3P) medicine can enhance diagnostic accuracy and improve patient care.

Methods
Multisymptom disease trajectories of HD patients collected from the Enroll-HD study were first aligned on a common disease timescale to account for heterogeneity in disease symptom onset and diagnosis. Following this, the aligned disease trajectories were clustered using the previously published Variational Deep Embedding with Recurrence (VaDER) algorithm and resulting progression subtypes were clinically characterized. Lastly, an AI/ML model was learned to predict the progression subtype from only first visit data or with data from additional follow-up visits.

Results
Results demonstrate two distinct subtypes, one large cluster (n = 7122) showing a relative stable disease progression and a second, smaller cluster (n = 411) showing a dramatically more progressive disease trajectory. Clinical characterization of the two subtypes correlates with CAG repeat length, as well as several neurobehavioral, psychiatric, and cognitive scores. In fact, cognitive impairment was found to be the major difference between the two subtypes. Additionally, a prognostic model shows the ability to predict HD subtypes from patients’ first visit only.

Conclusion
In summary, this study aims towards the paradigm shift from reactive to preventive and personalized medicine by showing that non-motor symptoms are of vital importance for predicting and categorizing each patients’ disease progression pattern, as cognitive decline is oftentimes more reflective of HD progression than its motor aspects. Considering these aspects while counseling and therapy definition will personalize each individuals’ treatment. The ability to provide patients with an objective assessment of their disease progression and thus a perspective for their life with HD is the key to improving their quality of life. By conducting additional analysis on biological data from both subtypes, it is possible to gain a deeper understanding of these subtypes and uncover the underlying biological factors of the disease. This greatly aligns with the goal of shifting towards 3P medicine.
Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer
Authors: Lee Seong Yun , Park Junyoung , Seo Sang Beom 
Published: May 2024

Abstract
Background
Colon cancer is the third most common cancer globally. The expression of histone deacetylase 3 (HDAC3) is upregulated, whereas the expression of tat interactive protein, 60 kDa (TIP60) is downregulated in colon cancer. However, the relationship between HDAC3 and TIP60 in colon cancer has not been clearly elucidated.

Objective
We investigated whether TIP60 could regulate the expression of HDAC3 and suppress colon cancer cell proliferation.

Methods
RNA sequencing data (GSE108834) showed that HDAC3 expression was regulated by TIP60. Subsequently, we generated TIP60-knockdown HCT116 cells and examined the expression of HDAC3 by western blotting and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). We examined the expression pattern of HDAC3 in various cancers using publicly available datasets. The promoter activity of HDAC3 was validated using a dual-luciferase assay, and transcription factors binding to HDAC3 were identified using GeneCards and Promo databases, followed by validation using chromatin immunoprecipitation-quantitative polymerase chain reaction. Cell proliferation and apoptosis were assessed using colony formation assays and fluorescence-activated cell sorting analysis of HCT116 cell lines.

Results
In response to TIP60 knockdown, the expression level and promoter activity of HDAC3 increased. Conversely, when HDAC3 was downregulated by overexpression of TIP60, proliferation of HCT116 cells was inhibited and apoptosis was promoted.

Conclusion
TIP60 plays a crucial role in the regulation of HDAC3 transcription, thereby influencing cell proliferation and apoptosis in colon cancer. Consequently, TIP60 may function as a tumor suppressor by inhibiting HDAC3 expression in colon cancer cells.
Interacting impacts of hydrological changes and air temperature warming on lake temperatures highlight the potential for adaptive management
Authors: Olsson Freya , Mackay Eleanor B. , Spears Bryan M. , Barker Philip , Jones Ian D. 
Published: May 2024

Abstract
Globally, climate warming is increasing air temperatures and changing river flows, but few studies have explicitly considered the consequences for lake temperatures of these dual effects, or the potential to manage lake inflows to mitigate climate warming impacts. Using a one-dimensional model, we tested the sensitivity of lake temperatures to the separate and interacting effects of changes in air temperature and inflow on a small, short-residence time (annual average ≈ 20 days), temperate lake. Reducing inflow by 70% increased summer lake surface temperatures 1.0–1.2 °C and water column stability by 11–19%, equivalent to the effect of 1.2 °C air temperature warming. Conversely, similar increases in inflow could result in lake summer cooling, sufficient to mitigate 0.75 °C air temperature rise, increasing to more than 1.1 °C if inflow temperature does not rise. We discuss how altering lake inflow volume and temperature could be added to the suite of adaptation measures for lakes.
Revisional surgery for malnutrition after SADI-S: prevalence, indications, techniques and outcomes
Authors: Sánchez-Pernaute Andrés , Lasses Bibiana , Antoñanzas Leyre López , Rubio Miguel Ángel , Marcuello Clara , Ferré Natalia Pérez , Torres Antonio , Pérez-Aguirre Elia 
Published: May 2024

Abstract
Key points
SADIS with short common limb (< 250 cm) is a malabsorptive operation.
Reoperation is advised in patients requiring admission for severe malnutrition.
Elongation of the common channel is the preferred revisional technique
Introduction: Single-Anastomosis Duodeno-Ileal bypass with Sleeve gastrectomy (SADI-S) is a modification of the duodenal switch. Initial common channel’s length was 200, and after malnutrition was detected in some patients, it was elongated to 250 or 300 cm. The present study analyzes presentation and treatment of malnutrition after SADI-S. Materials: Three hundred and thirty-three consecutive patients undergoing SADI-S between May 2007 and February 2019 were included. The common limb length was 200 cm in 50 cases, 250 cm in 211, 300 in 71 and 350 in 1. Thirty-one patients were admitted for severe hypoalbuminemia and 17 patients were submitted to revisional surgery, and constitute the series of our study. Mean weight before reoperation was 57 kg and mean body mass index (BMI) was 21 kg/m2. Mean number of daily bowel movements was 5,6. Results: Mean time to reoperation was 56 months. The limb was found shorter than expected in 6 cases. Revisional surgery was conversion into a Roux en Y duodenal switch in 3 cases, elongation of the common limb in 11 patients, duodeno-duodenostomy in 1 and duodeno-jejunostomy to the first jejunal loop in 2. Mean weight regain was 14 kg, and mean final BMI 26 kg/m2. Daily bowel movements were reduced to 1,3. Factors related to hypoalbuminemia were hypertension, poor-controlled diabetes, shorter common limb and liver-test alterations. Conclusion: SADI-S is expected to be less malabsorptive than previous biliopancreatic diversions. However, caution must be taken with certain patients to avoid postoperative malnutrition. Adequate follow up with long-term supplementation is required.
A journey through the history of PEGylated drug delivery nanocarriers
Authors: López-Estevez Ana M. , Gref Ruxandra , Alonso Maria J. 
Published: May 2024

AbstractThis note aims to inspire through providing a personal view of the development and potential Drug Delivery Nanocarriers functionalized with polythyleneglycol (PEG). This polymer has been used extensively in Pharmaceutical Technology in a variety of compositions, including polyethylene oxide (PEO)-based surfactants. However, the concept of PEGylation, which started in the 70’s, differs from the functionality of a surfactant, already discloses in the 50’s. Here, we strictly adhere to the biological functionality of PEGylated nanocarriers intended to have a reduced interaction with proteins and, therefore, modify their biodistribution as well as facilitate their diffusion across mucus and other biological barriers. We analyze how this concept has evolved over the years and the benefit obtained so far in terms of marketed nanomedicines and provide the readers with a prospect view of the topic.
Tight Closure, Coherence, and Localization at Single Elements
Authors: Epstein Neil 
Published: May 2024

AbstractIn this note, a condition (open persistence) is presented under which a (pre)closure operation on submodules (resp. ideals) over rings of global sections over a scheme X can be extended to a (pre)closure operation on sheaves of submodules of a coherent $$\mathcal {O}_X$$

O
X

-module (resp. sheaves of ideals in $$\mathcal {O}_X$$

O
X

). A second condition (glueability) is given for such an operation to behave nicely. It is shown that for an operation that satisfies both conditions, the question of whether the operation commutes with localization at single elements is equivalent to the question of whether the new operation preserves quasi-coherence. It is shown that both conditions hold for tight closure and some of its important variants, thus yielding a geometric reframing of the open question of whether tight closure localizes at single elements. A new singularity type (semi F-regularity) arises, which sits between F-regularity and weak F-regularity. The paper ends with (1) a case where semi F-regularity and weak F-regularity coincide, and (2) a case where they cannot coincide without implying a solution to a major conjecture.
Dental treatment outcomes in Thai children treated for severe early-childhood caries under general anaesthesia and non-pharmacological behaviour management: a retrospective study
Authors: Pratyaprateep N. , Jirarattanasopha V. , Smutkeeree A. 
Published: May 2024

Abstract
Purpose
The aim of this study was to compare dental-treatment outcomes, oral-hygiene improvement, and patient co-operation during follow-up visits between children treated under general anaesthesia (GA) and non-pharmacological behaviour management (NP).

Methods
This retrospective study reviewed the dental chart records of healthy patients less than 71-month-old with severe early childhood caries (S-ECC) from 2008 to 2020 with at least a 6-month follow-up. The demographical data, dental-treatment outcomes, oral-hygiene status, and patient behaviour at the follow-up visits were analysed by the Mann–Whitney U test, Pearson’s Chi-square, Fisher’s exact test, Friedman test, and Wilcoxon test with a significance level of 0.05.

Results
This study included 210 GA cases and 210 age-matched control NP cases. The GA group had a significantly higher caries experience, lower patient co-operation, poorer oral hygiene, and higher number of complex dental treatment than the NP group at baseline (p < 0.001). The number of children who had incomplete dental treatment under non-pharmacological behaviour management was higher than the GA group. After treatment, the number of new carious teeth in the NP group was significantly higher than in the GA group only at the 6-month follow-up. However, there was no significant difference in treatment failure, oral-hygiene improvement, and patient behaviour between groups.

Conclusion
Although patients in the GA group had higher dental and behaviour problems than the NP group, the overall dental-treatment outcomes, including oral hygiene and behaviour improvement, were not significantly different between groups Therefore, regular follow-up and preventive treatment in the maintenance phase are essential for children with severe early-childhood caries.
Endowments, patience types, and uniqueness in two-good HARA utility economies
Authors: Loi Andrea , Matta Stefano 
Published: May 2024

AbstractThis paper establishes a link between endowments, patience types, and the parameters of the HARA Bernoulli utility function that ensure equilibrium uniqueness in an economy with two goods and two impatience types with additive separable preferences. We provide sufficient conditions that guarantee uniqueness of equilibrium for any possible value of $$\gamma $$
γ
in the HARA utility function $$\frac{\gamma }{1-\gamma }\left( b+\frac{a}{\gamma }x\right) ^{1-\gamma }$$

γ

1
-
γ

b
+

a
γ

x

1
-
γ

. The analysis contributes to the literature on uniqueness in pure exchange economies with two-goods and two agent types and extends the result in Loi and Matta (2022).
Approximate expressions for the capillary force and the surface area of a liquid bridge between identical spheres
Authors: Bagheri Meysam , Roy Sudeshna , Pöschel Thorsten 
Published: May 2024

AbstractWe consider a liquid bridge between identical spheres and present approximate expressions for the capillary force and the exposed surface area of the liquid bridge as functions of the liquid bridge’s total volume and the sphere separation distance. The radius of the spheres and the solid–liquid contact angle are parameters that enter the expressions. These expressions are needed for efficient numerical simulations of drying suspensions and other systems involving liquid bridges whose volume or shape vary in time.