bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Chronic Hyperplastic Candidiasis in the Tongue using Machine Learning: A Study of 186 Cases
Authors: Liskova Veronika , Liska Jan , Moztarzadeh Omid , Posta Petr , Topolcan Ondrej , Jamshidi Alireza , Hauer Lukas 
Published: May 2024

Introduction
This study examines the distribution of 186 Chronic Hyperplastic Candidiasis (CHC) cases verified by biopsy within the oral cavity, focusing on the prevalence in the tongue (72 cases) versus other oral locations (114 cases).

Methods
Utilizing the Random Forest Regressor (RFR), a robust machine learning algorithm, we analyze 16 unique risk factors to predict CHC incidence in the tongue. Linear regression is employed to evaluate the model's performance.

Results
The RFR demonstrates high accuracy in predicting CHC presence in various oral sites. The study highlights the impact of risk factors on CHC prevalence and the importance of CHC's location in the oral cavity for tailored diagnostic and treatment approaches. The findings suggest the Random Forest Regressor's potential as a tool for healthcare professionals in the early identification and diagnosis of CHC, enhancing disease understanding and improving patient care.

Conclusion
The RFR proves effective in predicting CHC occurrence in different oral areas. The clinical significance of Machine Learning method usage lies in the optimal evaluation of true pathogenetic factors and their relation patterns for CHC development in the tongue. Notably, most tongue CHC patients were non-smokers (63.9%), and female patients slightly outnumbered males (54.2%), challenging the common association of CHC with male smokers. A significant association exists between gastroesophageal reflux and tongue CHC (p=0.01), and a similar trend is noted for thyropathy in lingual lesions compared to other CHC locations (p=0.09). These findings underscore the necessity for clinicians to consider negative cultivations in lingual CHC cases (20.8% of cases), ensuring comprehensive evaluation and treatment.
Book Review: Applications of Ion Exchange Materials in Biomedical
Industries
Authors: Sasikumar G. Kausalya , Thangadurai T. Daniel , Balla Putrakumar , Gangadharan T.K. Anusree , Pothu Ramya Krishna , Boddula Rajender 
Published: May 2024

Abstract::
The book titled “Applications of Ion Exchange Materials in Biomedical Industries,” edited by Inamuddin, was published by Springer in 2019. The book has 235 pages, and the print version has ISBN 978-3-030-06081-7. The eBook version has ISBN 978-3-030-06082-4 and is available at https://doi.org/10.1007/978-3-030-06082-4. Ion exchange chromatography has be-come increasingly popular in recent years due to its use in various industries, including biotech-nology, pharmaceuticals, agriculture, and the environment. The book "Applications of Ion Ex-change Materials in Biomedical Industries," edited by Inamuddin and published by Springer in 2019, covers the use of ion exchange materials in biomedical applications. The book outlines the principles of ion exchange chromatography (IEC), a crucial technology used to separate ionic chemicals through ion exclusion and partition. It also covers IEC in separating, purifying, identi-fying, and extracting substances, such as amino acids, morphine, nucleotides, nucleosides, sorbi-tol, vitamins, purines, and pyrimidines. This book review will be useful to researchers, industrial-ists, medical professionals, and engineers in understanding the concept and applications of ion exchange materials.
Pharmaceutical Market Access in Latin America: Analyzing Approval
Requirements in Three Key Nations: Ecuador, Dominican Republic and
Nicaragua
Authors: Thakkar Jhanvi , Patel Ayush , Desai Jagruti , Patel Mehul , Shah Umang , Patel Ashish , Patel Krishi , Patel Swayamprakash 
Published: May 2024

:
This article presents a comprehensive and comparative analysis of the regulatory frameworks governing the approval of pharmaceuticals in the Dominican Republic, Ecuador, and Nicaragua. It delves into the intricate scientific terminology and complex procedures inher-ent in these regulatory systems, shedding light on the demanding requirements that pharmaceu-tical companies must fulfil to secure market access in these countries. Employing a comparative approach, the article explores both the analogy and differences in the approval processes, focus-ing on factors such as safety standards, efficacy assessments, clinical trial prerequisites, post-marketing surveillance, and overall transparency. The findings contribute to a deeper under-standing of the scientific accuracy and ongoing efforts towards regulatory harmonisation within the pharmaceutical industry across these countries. Furthermore, this study aims to define the regulatory requirements for drug approval in the LATAM region, explicitly emphasising the Dominican Republic, Ecuador, and Nicaragua. It provides insights into the current pharmaceuti-cal market landscape in Latin America, compares the regulatory requirements for drug approval in these three countries, and offers guidance on preparing dossiers for obtaining authorisation of pharmaceutical drug products. By examining the similarities and differences in regulatory stand-ards, this article facilitates a comprehensive understanding of the stringency ratios between these countries and assists companies in navigating the specific regulatory landscapes to achieve suc-cessful drug approvals
The differences between static stretching and proprioceptive neuromuscular facilitation stretching on flexibility: a gender review
Authors: Fenanlampir Albertus , Lumba Andreas J. F , Mutohir Toho Cholik , Jiménez José Vicente García 
Published: May 2024

Proprioceptive neuromuscular facilitation (PNF) is the latest method used in flexibility training. This study shows something different from other studies. The purpose of this study was whether there were differences in flexibility in male and female students as a result of the static stretching training method and the PNF stretching training method. The samples in this study were 80 male and female students, which were taken randomly from the male population of 56 people and the female population of 45 people, so that a total of 101 people. The results showed that the two methods showed a significant improvement. However, the PNF stretching training method was more effective than the static stretching training method in increasing flexibility. Both applied to male students and female students. Although the PNF stretching training method has been proven to increase flexibility in both males and females, students and physical education teachers need to pay attention to this training method and do it regularly and continuously by considering the advantages and disadvantages of each method. The suggestions for further research are to carry out further, complete research, which is related to this research, by taking into account the essential differences between males and females, such as physical and physiological growth and development.
Legal Custom in Russian Law: the Genesis of Conceptual Foundations and Modern Status
Authors: Minina N. V. , Pyltcina M. V. 
Published: May 2024

Relevance. The role of legal custom in the Russian system of sources of law is ambiguous even today, although historically it has long acted as the main regulator of public relations. If in ancient times the custom was used everywhere, now it is widespread in private law and some complex branches of Russian law, and its application in the public legal sphere still requires scientific argumentation.Purpose: to study the genesis of the conceptual foundations and the current status of legal custom in Russia.Objectives: to study the origin, essence and meaning of legal custom in the Russian system of sources of law.Methodology. On the basis of the dialectical method of scientific cognition, as well as a combination of methods of analysis and synthesis, a set of general scientific research methods, as well as private scientific and special legal ones, such as: historical, system-structural, formal-logical, formal-legal, comparative-legal, etc.The results of the study are of a theoretical and applied nature, as they allow us to recognize legal custom as the original source of law, which historically gave rise to the entire existing system of forms of law. The signs of legal custom are revealed, its place and role in the system of sources of law are determined. The issues of the application of legal custom in civil, business and international private law are studied.Conclusions. The study of the genesis of the conceptual foundations and the modern status of legal custom has shown that it is rightfully recognized as an integral fundamental part of the system of sources of Russian law, has a subsidiary law-enforcement character and should be inferior in legal force to a normative act and a contract.
Violent Crime Against Persons in Modern Russia: State and Problems of Criminological Characteristics
Authors: Yakhontova Y. S. 
Published: May 2024

Relevance. Violent crimes that infringe on unshakable human values, namely life and health, are an integral part of society's life. The rapid change in social, economic and political conditions leads to the intensification of social tension of the population and can provoke an increase in the level of violent crime. Modern realities make it necessary to study and analyze up-to-date information about the state of violent crime, as well as to identify existing shortcomings of the accounting system for the crimes under consideration.The purpose of the study is to improve the efficiency of law enforcement agencies based on a systematic study of the criminological characteristics of violent crime against the individual, its state and dynamics in modern Russia, including identifying existing shortcomings in the system of accounting for violent crimes by internal affairs agencies and developing ways to overcome them.The objectives of the study are to identify the real state of violent crime against the individual in modern Russia; to identify changes in its state in the period from 2018 to 2022; to establish the main factors that can have a significant impact on official statistics and accounting and registration discipline in the system of the Ministry of Internal Affairs of Russia, and their accounting.Methodology. The methodological basis of the research consists of general scientific and private scientific methods of cognition: analysis, synthesis, formal-logical, systematic, statistical.Results. The article provides an analysis of the main criminological indicators of violent crime in modern Russia. Particular factors affecting the effectiveness of the crime accounting system are considered, ways of entering information by employees of the Ministry of Internal Affairs of Russia that may affect the reliability of official statistical data are considered and classified.Conclusion. Within the framework of the study, the range of crimes classified as violent was determined, the validity of attributing crimes committed with the use of instrumental violence to the category of violent crimes against the person was considered. The necessity of introducing separate statistical forms aimed at collecting information about violent crime is substantiated.Factors that may have an impact on the reliability and accuracy of official data are considered, special attention was paid to such a phenomenon as artificial latency of crimes. The interrelation of the method of assessing the effectiveness of the activities of territorial internal affairs bodies with the phenomenon of artificial latency of crimes is analyzed. In our opinion, a real reduction in the level of artificial latent crime could be influenced by a change in the accounting system for evaluating the effectiveness of the activities of territorial internal affairs bodies.
The Religiosity of Soviet youth in the Mirror of Domestic Social Studies of the 1920-1970s.
Authors: Apanasenok A. V. 
Published: May 2024

The relevance of the work is related to the heuristic significance of clarifying the religious values place in the life of Soviet society, as well as the need for a historiographical understanding of the process of relaying confessional traditions in the Soviet Union.The purpose of the research: a critical analysis of information on religiosity level of Soviet youth, published by Russian authors in the 1920–1970s.Objectives: to study the statistical data of domestic social scientists regarding the religiosity of Soviet youth in the 1920–1970s; to consider the factors that influenced such statistics; to assess the correspondence of the published statistics to the real picture of the younger generations of Soviet citizens attitude to confessional values.Methods. During the preparation of the paper the author relied on the traditional methodology of historical and sociological research: historical-statistical, comparative-historical methods, as well as the method of historical induction.Results. The paper examines the dynamics of changes in data on the religiosity of young USSR citizens obtained by Soviet social scientists during surveys of the 1920–1970s, examines the causes of a sharp drop in the declared level of religiosity of schoolchildren and students since the 1930s, compares published and unpublished information about the attitude of representatives of these social categories to confessional culture.Conclusions. The research shows that the level of youth religiosity demonstrated by Soviet social studies has decreased tenfold over the past five decades. It is concluded that the data on the relevant issues were published by voters, reflecting only the results of the polls acceptable from an ideological point of view. To obtain such results, social scientists were usually helped by the interviewees themselves, who sought to remain "conscious" citizens in the eyes of the observing authorities. At the same time, the outwardly demonstrated skepticism of religion by young people often hid doubts about the atheistic picture of the world or interest in confessional traditions as one of the foundations of culture.
Analysis of the Fulfillment of the Tasks of the X Five-Year Plan (1976-1980) Industrial Enterprises of the Kursk Regionviziltir
Authors: Irmakova D. A. 
Published: May 2024

Relevance. In the years of the X five-year plan the country's industry was faced with the task of improving the efficiency and quality of production at minimal cost by introducing new technologies, mechanizing production and reducing manual labor. But the administrative and command management system turned out to be unable to respond quickly, new technologies were poorly implemented, and existing equipment was outdated. Using the example of the implementation of the tasks of the X five-year plan at the industrial enterprises of the Kursk region, it is possible to assess the positive and negative sides of the Soviet production management system.Purpose. To investigate the results of the X five-year plan in the industrial production of the Kursk region and identify the results of the main directions of industrial development set by the XXV Congress of the CPSU at the regional level.Objectives: to analyze the reports of industrial enterprises of the region to assess the results of production activities based on the results of the X five-year plan.Methodology. Scientific methods were used in the research: synthesis, analysis, comparison, analogy, generalization, induction, deduction.Results. The tasks of the X five-year plan at the industrial enterprises of the region were not fulfilled in full. In the food industry, there was a failure to meet targets for the volume of products produced. The introduction of new technologies and automation were carried out at a slow pace, as a result of which labor productivity increased slightly. Mechanical engineering turned out to be the most promising industry in the region.Conclusion. The all-Union trends aimed at fulfilling the ten-year plan have found expression in the Kursk region. But the efforts made by the management of enterprises did not always give a positive result. Almost all the studied enterprises in the region slightly exceeded the planned indicators. The most promising enterprises turned out to be in the machine-building industry, where new equipment was introduced, production processes were mechanized, there was an influx of labor and labor productivity increased.
Legal Regulation of Entrepreneurial Activity in Special Economic Zones: Problems and Prospects
Authors: Konstantin G. Balashov K. G. , Kravchenko N. V. 
Published: May 2024

Relevance.The development of territories defined as special economic zones in the Russian Federation continues to be in the focus of the state policy aimed at attracting investments of both domestic and international nature in various sectors of economic activity: from manufacturing to tourism and innovative technologies. Under these conditions, the task of quality legal regulation of entrepreneurial initiatives and ensuring conditions for the successful operation and protection of business assistants in SEZ territories becomes more relevant.The purposeof the study is to assess the existing regulatory mechanisms, identify problems in the sphere of SEZ residents' activities, and determine promising directions for further development of legal relations that contribute to the increase of investment potential in the territory of the country.Objectives.Analysis of the existing mechanisms of control and legal regulation of the activities of economic entities with the status of SEZ residents, the study of shortcomings in the legal framework concerning the procedures for depriving business structures of the SEZ resident status, which directly affects the stability of their functioning.Methodology. To achieve the set objectives, we used various methodological approaches, in particular, deductive, system-analytical, formal-logical, which allowed us to review the current mechanisms of regulating the activities of economic entities-residents of SEZs, and from the general theoretical provisions to draw specific conclusions about the prospects for the development of the legal environment for the regulation of entrepreneurial activity in SEZs.Resultsof the study are a critical understanding of the existing approaches to legal regulation and support of SEZ activities, as well as the adjustment of the regulatory framework taking into account the identified shortcomings, which will improve the effectiveness of the SEZ institution and contribute to a balanced economic development of regions and stabilisation of the investment environment at the macro level.Conclusion.The article presents proposals for amendments aimed at eliminating the identified problems concerning the clarification of the legal status of residents and mechanisms for controlling their activities, which should contribute to improving the effectiveness of legal regulation and ensuring the stability of entrepreneurial structures in SEZs.
The Effect of a Novel Video Game on Young Soccer Players' Sports Performance and Attention: Randomized Controlled Trial
Authors: Feria-Madueño Adrian , Monterrubio-Fernández Germán , Mateo Cortes Jesus , Carnero-Diaz Angel 
Published: May 2024

Abstract

Background
Currently, the fusion of technology and sports is inevitable. The integration of various systems and devices has brought about significant transformations in established sports practices, impacting not only the rules but also physiological, biomechanical, and even psychological aspects.

Objective
The purpose of this study was to analyze the effect of an attention intervention through a video game on young soccer players.

Methods
Twelve young male soccer players (age: mean 8.5, SD 1 years) were divided into 2 groups: a control group (CG; n=10) and an experimental group (EG; n=10). During the 6-week training program, the EG received attention training through a video game twice a week for 15 minutes per session. Pre- and postintervention measurements included a specific decision-making soccer test and interviews with coaching staff. Additionally, success in the video game, muscular activity, and sweat levels were monitored.

Results
The EG demonstrated a significant improvement in video game success following the intervention program, as indicated by the achieved level (P<.001). However, no significant differences were found between groups regarding electromyographic (EMG) activity (P=.21) and sweating (P=.20). Prior to implementing the attention training program, both groups exhibited similar data for variables related to decision-making and execution mechanisms (≤10%). Only 2 decision-making variables exceeded 10% but remained below 15% (Shot_D=13.35%; Marking_with_Ball_D=−12.64%). Furthermore, changes in attacking action variables were more pronounced in execution-related variables, except for dribbling and fixing. Conversely, in defensive action variables, changes were greater in decision-related variables, except for marking with the ball and marking without the ball.

Conclusions
Our findings reveal that incorporating a specific attentional video game into a soccer training program enhances decision-making compared to a program without the video game. Therefore, it is advisable for practitioners to consider using this tool due to its high efficiency in terms of economic and temporal costs, particularly in improving a key psychological variable.
Pengaruh Asfiksia Terhadap Kejadian Kematian Neonatal Di Provinsi Jawa Timur
Authors: Rahmawati Delia 
Published: May 2024

ABSTRAK
Kejadian kematian neonatal masih menjadi salah satu permasalahan utama di Provinsi Jawa Timur. Angka kematian neonatal di Provinsi Jawa Timur pada tahun 2019 mencapai 5,2/1.000 kelahiran hidup. Tujuan penelitian ini untuk menganalisis pengaruh antara asfiksia terhadap kematian neonatal di Provinsi jawa Timur tahun 2019. Jenis penelitian ini adalah observasi analitik dengan desain cross sectional. Data yang digunakan bersumber dari profil kesehatan Provinsi Jawa Timur tahun 2019. Teknik analisis data menggunakan uji regresi linier dan uji kolmogorov-smirnov. Hasil penelitian angka kematian neonatal di Provinsi Jawa Timur tahun 2019 mengalami penurunan dibandingkan angka kematian neonatal ditahun sebelumnya. Kasus Asfiksia mengalami peningkatan pada tahun 2019 dibandingkan pada tahun 2018. Penelitian ini menunjukkan terdapat pengaruh antara asfiksia (p=0,04) terhadap kejadian kematian neonatal di Provinsi Jawa Timur. Kesimpulan dari penelitian ini kematian neonatal di Provinsi Jawa Timur pada tahun 2019 mengalami penurunan dibandingkan tahun sebelumnya dan terdapat pengaruh antara asfiksia dengan kejadian kematian neonatal di Provinsi Jawa Timur.

Kata Kunci: Kematian Neonatal, Pengaruh, Asfiksia