bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between depression and anxiety and use of oral health services and tooth loss
Authors: Okoro Catherine A. , Strine Tara W. , Eke Paul I. , Dhingra Satvinder S. , Balluz Lina S. 
Published: September 2011

Okoro CA, Strine TW, Eke PI, Dhingra SS, Balluz LS. The association between depression and anxiety and use of oral health services and tooth loss. Community Dent Oral Epidemiol 2012; 40: 134–144. © 2011 John Wiley & Sons A/SAbstract –  Objective:  The purpose of this study is to examine the associations among depression, anxiety, use of oral health services, and tooth loss.Methods:  Data were analysed for 80 486 noninstitutionalized adults in 16 states who participated in the 2008 Behavioral Risk Factor Surveillance System. Binomial and multinomial logistic regression analyses were used to estimate predicted marginals, adjusted prevalence ratios, adjusted odds ratios (AOR) and their 95% confidence intervals (CI).Results:  The unadjusted prevalence for use of oral health services in the past year was 73.1% [standard error (SE), 0.3%]. The unadjusted prevalence by level of tooth loss was 56.1% (SE, 0.4%) for no tooth loss, 29.6% (SE, 0.3%) for 1–5 missing teeth, 9.7% (SE, 0.2%) for 6–31 missing teeth and 4.6% (SE, 0.1%) for total tooth loss. Adults with current depression had a significantly higher prevalence of nonuse of oral health services in the past year than those without this disorder (P < 0.001), after adjustment for age, sex, race/ethnicity, education, marital status, employment status, adverse health behaviours, chronic conditions, body mass index, assistive technology use and perceived social support. In logistic regression analyses employing tooth loss as a dichotomous outcome (0 versus ≥1) and as a nominal outcome (0 versus 1–5, 6–31, or all), adults with depression and anxiety were more likely to have tooth loss. Adults with current depression, lifetime diagnosed depression and lifetime diagnosed anxiety were significantly more likely to have had at least one tooth removed than those without each of these disorders (P < 0.001 for all), after fully adjusting for evaluated confounders (including use of oral health services). The adjusted odds of being in the 1–5 teeth removed, 6–31 teeth removed, or all teeth removed categories versus 0 teeth removed category were increased for adults with current depression versus those without (AOR = 1.35; 95% CI = 1.14–1.59; AOR = 1.83; 95% CI = 1.51–2.22; and AOR = 1.44; 95% CI = 1.11–1.86, respectively). The adjusted odds of being in the 1–5 teeth removed and 6–31 teeth removed categories versus 0 teeth removed category were also increased for adults with lifetime diagnosed depression or anxiety versus those without each of these disorders.Conclusions:  Use of oral health services and tooth loss was associated with depression and anxiety after controlling for multiple confounders.
Head and neck amyloidosis: clinicopathological features and immunohistochemical analysis of 14 cases
Authors: Gouvêa Adriele Ferreira , Ribeiro Ana Carolina Prado , León Jorge Esquiche , Carlos Román , de Almeida Oslei Paes , Lopes Márcio Ajudarte 
Published: September 2011

J Oral Pathol Med (2012) 41: 178–185Background:  Amyloidosis is associated with or caused by amyloid deposition. These fibrillar proteins may be deposited extracellularly causing tissue damage or impairment.Objectives:  The aim of the study was to retrospectively review pathology archives in two oral diagnostic centers for cases fulfilling criteria of amyloidosis and to differentiate AA and AL types of amyloidosis.Methods:  The clinicopathological features, alkaline Congo red staining, with and without pretreatment with potassium permanganate, and immunohistochemical (IHC) staining with anti‐AA, anti‐kappa (κ), and anti‐lambda (λ) light chain antibodies were carried out and analyzed.Results:  The search identified 14 cases. Ten patients were women and four were men, with a mean age of 58 years. Eleven patients had systemic involvement by amyloidosis (associated either with multiple myeloma or plasma cell dyscrasia/monoclonal gammopathies), while three presented the localized type, one of them associated with plasmacytoma. All cases showed positivity for κ or λ light chains (AL‐amyloid) and presented resistance to the potassium permanganate pretreatment.Conclusions:  Our results show that the head and neck region is preferentially affected by systemic AL‐amyloidosis, usually associated with plasma cell dyscrasia. Interestingly, two cases affected by inflammatory rheumatic diseases presented AL‐amyloid deposition. Moreover, even after pretreatment with potassium permanganate, which was helpful in highlighting the presence of AL‐amyloid, in agreement with the IHC findings, clinical classifications should be carefully made in systemic amyloidosis.
A clinico‐demographic analysis of maxillofacial trauma in the elderly
Authors: Al‐Qamachi Laith Hussein , Laverick Sean , Jones D.C. 
Published: September 2011

doi: 10.1111/j.1741‐2358.2010.00431.xA clinico‐demographic analysis of maxillofacial trauma in the elderlyIntroduction:  The elderly represent an increasing proportion of society. Management of maxillofacial trauma in this population may be complicated by coexisting medical conditions, requiring multi‐disciplinary care.Methods:  This retrospective audit assesses the incidence and pattern of maxillofacial trauma in elderly patients (≥60 years) presented to the Merseyside Regional Maxillofacial Unit. Over the time period of 2003, 2004 and 2005, 7905 trauma patients presented to the accident and emergency department, of whom 757 were elderly (10%).Results:  Results indicated that the male to female ratio was 1:1.4. The commonest cause of injury was a fall (83%) followed by an assault (6%); the majority of falls occurring in the home.Conclusion:  Management of maxillofacial injuries in this population should focus on targeted prevention programmes, which address known risk factors for falling. We believe that this is a public health issue. Members of the maxillofacial team should be aware of common risk factors of falls in elderly. Better collaboration with the Medicine for Elderly team should be considered at an early stage on managing these patients.
Management of a post‐radiotherapy xerostomic patient – a case report
Authors: Singh Yashpal , Saini Monika , Siwach Amit , Mittal Rashmi 
Published: September 2011

doi: 10.1111/j.1741‐2358.2011.00519.xManagement of a post‐radiotherapy xerostomic patient – a case reportObjective:  The objective of the study was to fabricate complete denture with palatal reservoir filled with artificial saliva for a post radiotherapy edentulous patient.Background:  Xerostomia is a subjective complaint rather than a disease. It is caused by irradiation, medication, Sjogren's syndrome & neurological factors such as stress. Radiotherapeutic treatment of head and neck cancer patients often causes long term dysfunction involving their salivary function, swallowing capabilities & taste. All three of these domains are affected by radiation‐ induced damage to the salivary glands. This in turn results in poor retention of complete denture, frequent trauma to alveolar ridge & other oral infections. All these events drastically affects quality of life of ageing patients.Material and Method:  A complete denture in heat cure acrylic resin was fabricated in which a palatal reservoir was made on the palatal side.Results:  Problems arising due to xerostomia were reduced to a great extent.Conclusion:  Prosthodontic management of Xerostomic patient include several techniques. This paper presents a case report of post radiotherapy edentulous patient in which complete denture with palatal reservoir filled with artificial saliva was fabricated.
Exercise Training Improves the Defective Centrally Mediated Erectile Responses in Rats with Type I Diabetes
Authors: Zheng Hong , Mayhan William G. , Patel Kaushik P. 
Published: September 2011

ABSTRACTIntroductionErectile dysfunction is a serious and common complication of diabetes mellitus. Apart from the peripheral actions, central mechanisms are also responsible for the penile erection.AimThe goal of the present study was to determine the impact of exercise training (ExT) on the centrally mediated erectile dysfunction in streptozotocin (STZ)-induced type I diabetic (T1D) rats.MethodsMale Sprague–Dawley rats were injected with STZ to induce diabetes mellitus. Three weeks after STZ or vehicle injections, rats were assigned to either ExT (treadmill running for 3–4 weeks) or sedentary groups to produce four experimental groups: control + sedentary, T1D + sedentary, control + ExT, and T1D + ExT.Main Outcome MeasureAfter 3–4 weeks ExT, central N-methyl-D-aspartic acid (NMDA) or sodium nitroprusside (SNP)-induced penile erectile responses were measured. Neuronal nitric oxide synthase (nNOS) expression in the paraventricular nucleus (PVN) of the hypothalamus was measured by using histochemistry, real time polymerase chain reaction (PCR) and Western blot approaches.ResultsIn rats with T1D, ExT significantly improved the blunted erectile response, and the intracavernous pressure changes to NMDA (50 ng) microinjection within the PVN (T1D + ExT: 3.0 ± 0.6 penile erection/rat; T1D + sedentary: 0.5 ± 0.3 penile erection/rat within 20 minutes, P &lt; 0.05). ExT improved erectile dysfunction induced by central administration of exogenous nitric oxide (NO) donor, SNP in T1D rats. Other behavior responses including yawning and stretching, induced by central NMDA and SNP microinjection were also significantly increased in T1D rats after ExT. Furthermore, we found that ExT restored the nNOS mRNA and protein expression in the PVN in T1D rats.ConclusionThese results suggest that ExT may have beneficial effects on the erectile dysfunction in diabetes through improvement of NO bioavailability within the PVN. Thus, ExT may be used as therapeutic modality to up-regulate nNOS within the PVN and improve the central component of the erectile dysfunction in diabetes mellitus.
Neural Activation Toward Erotic Stimuli in Homosexual and Heterosexual Males
Authors: Kagerer Sabine , Klucken T.m. , Wehrum Sina , Zimmermann Mark , Schienle Anne , Walter Bertram , Vaitl Dieter , Stark Rudolf 
Published: September 2011

ABSTRACT

Introduction
Studies investigating sexual arousal exist, yet there are diverging findings on the underlying neural mechanisms with regard to sexual orientation. Moreover, sexual arousal effects have often been confounded with general arousal effects. Hence, it is still unclear which structures underlie the sexual arousal response in homosexual and heterosexual men.

Aim
Neural activity and subjective responses were investigated in order to disentangle sexual from general arousal. Considering sexual orientation, differential and conjoint neural activations were of interest.

Methods
The functional magnetic resonance imaging (fMRI) study focused on the neural networks involved in the processing of sexual stimuli in 21 male participants (11 homosexual, 10 heterosexual). Both groups viewed pictures with erotic content as well as aversive and neutral stimuli. The erotic pictures were subdivided into three categories (most sexually arousing, least sexually arousing, and rest) based on the individual subjective ratings of each participant.

Main Outcome Measures
Blood oxygen level-dependent responses measured by fMRI and subjective ratings.

Results
A conjunction analysis revealed conjoint neural activation related to sexual arousal in thalamus, hypothalamus, occipital cortex, and nucleus accumbens. Increased insula, amygdala, and anterior cingulate gyrus activation could be linked to general arousal. Group differences emerged neither when viewing the most sexually arousing pictures compared with highly arousing aversive pictures nor compared with neutral pictures.

Conclusion
Results suggest that a widespread neural network is activated by highly sexually arousing visual stimuli. A partly distinct network of structures underlies sexual and general arousal effects. The processing of preferred, highly sexually arousing stimuli recruited similar structures in homosexual and heterosexual males.
Time to Onset of Action of Vardenafil: A Retrospective Analysis of the Pivotal Trials for the Orodispersible and Film-Coated Tablet Formulations
Authors: Debruyne Frans M.J. , Gittelman Marc , Sperling Herbert , Börner Matthias , Beneke Manfred 
Published: September 2011

Abstract

Introduction
Patients and physicians consider a rapid onset of action to be an important attribute of oral pharmacotherapy for erectile dysfunction.

Aim
To investigate the time to onset of action of a new orodispersible tablet (ODT) formulation of vardenafil.

Methods
A post hoc integrated analysis was performed on data from two 12-week, double-blind, multicenter, randomized, parallel-group, placebo-controlled phase III trials of 10 mg vardenafil ODT. Data for the vardenafil film-coated tablet were generated from a retrospective integrated analysis at week 12 of four double-blind, multicenter, randomized, parallel-group, fixed-dose, placebo-controlled phase III trials. Time intervals (in 15-, 30-, and 60-minute increments, up to ≥6 hours after study medication intake) were determined for the period between dosing and start of sexual activity (with the intention of intercourse).

Main Outcome Measures
The total number of sexual intercourse attempts and Sexual Encounter Profile question 3 (SEP3) success rates were calculated per time interval.

Results
Within 15 minutes postdosing, mean per-patient SEP3 success rates were 62.5% (vardenafil ODT) vs. 29.4% (placebo), with corresponding overall SEP3 success rates of 59.8% and 38.2%. In this time interval, 5.3% vs. 2.8% of all sexual activity attempts were initiated by subjects taking vardenafil ODT (n = 89) or placebo (n = 62), respectively.
At 16–30 minutes postdosing, SEP3 success rates were 65.3% and 32.6% (mean per-patient) and 70.2% and 51.0% (overall) for vardenafil ODT vs. placebo, respectively, with a corresponding 10.4% and 8.7% of all sexual activity attempts being made by subjects taking vardenafil ODT (n = 170) or placebo (n = 118).
Comparable results were observed for vardenafil 10 and 20 mg film-coated tablet at corresponding time intervals.

Conclusions
Vardenafil ODT shows a rapid onset of action comparable with that of vardenafil film-coated tablet. In those men who begin sexual activity within 30 minutes after dosing, the majority of sexual attempts lead to successful intercourse.
The final parsec problem: aligning a binary with an external accretion disc
Authors: Nixon C. J. , King A. R. , Pringle J. E. 
Published: September 2011

Abstract
We consider the interaction between a binary system (e.g. two supermassive black holes or two stars) and an external accretion disc with misaligned angular momentum. This situation occurs in galaxy merger events involving supermassive black holes, and in the formation of stellar mass binaries in star clusters. We work out the gravitational torque between the binary and disc, and show that their angular momenta Jb, Jd stably counteralign if their initial orientation is sufficiently retrograde, specifically if the angle θ between them obeys cos θ &lt; −Jd/2Jb, on a time short compared with the mass gain time of the central accretor(s). The magnitude Jb remains unchanged in this process. Counteralignment can promote the rapid merger of supermassive black hole binaries, and possibly the formation of coplanar but retrograde planets around stars in binary systems.
Too small to succeed? Lighting up massive dark matter subhaloes of the Milky Way
Authors: Di Cintio Arianna , Knebe Alexander , Libeskind Noam I. , Yepes Gustavo , Gottlöber Stefan , Hoffman Yehuda 
Published: September 2011

Abstract
Using Constrained Local UniversE Simulations (CLUES) of the formation of the Local Group in a cosmological context, we investigate the recently highlighted problem that the majority of the most massive dark subhaloes of the Milky Way (MW) are too dense to host any of its bright satellites. In particular, we examine the influence of baryonic processes and find that they leave a twofold effect on the relation between the peak of the rotation curve and its position (Vmax and Rmax). Satellites with a large baryon fraction experience adiabatic contraction, thus decreasing Rmax while leaving Vmax more or less unchanged. Subhaloes with smaller baryon fractions undergo a decrease in Vmax possibly due to outflows of material. Furthermore, the situation of finding subhaloes in simulations that lie outside the confidence interval for possible hosts of the bright MW dwarf spheroidals appears to be far more prominent in cosmologies with a high σ8 normalization and depends on the mass of the host. We conclude that the problem cannot be simply solved by including baryonic processes and hence demands further investigations.
Scale-dependent bias from primordial non-Gaussianity with trispectrum
Authors: Gong Jinn-Ouk , Yokoyama Shuichiro 
Published: September 2011

Abstract
We study the scale-dependent bias of the halo power spectrum arising from primordial non-Gaussianity. We present an analytic result of the halo bias including up to the trispectrum contributions. We find that the scale-dependent bias opens a new possibility of probing the relation between the non-linearity parameters fNL and τNL.
The Effect of Increased Travel Reimbursement Rates on Health Care Utilization in the VA
Authors: Nelson Richard E. , Hicken Bret , West Alan , Rupper Randall 
Published: September 2011

AbstractPurpose: The reimbursement rate that eligible veterans receive for travel to Department of Veterans Affairs (VA) facilities increased from 11 to 28.5 cents per mile on February 1, 2008. We examined the effect of this policy change on utilization of outpatient, inpatient, and pharmacy services, stratifying veterans based on distance from a VA facility.Methods: We compared health care utilization and costs on a sample of VA patients in the 10.5 months before the reimbursement rate increase and the 10.5 months after the reimbursement rate increase. Using a difference‐in‐difference technique, we ran multivariable logistic and count regressions for utilization and generalized linear models (GLM) for cost outcomes. Regressions were stratified based on urban and rural residence, as well as by distance thresholds.Findings: Our cohort contained 250,958 veterans, 76.7% (n = 192,559) of whom were eligible to receive a travel reimbursement. After the reimbursement rate increase, eligible veterans at all distances were 6.8% more likely to have an outpatient encounter and had 2.6% more outpatient encounters in the VA compared to those not eligible for the reimbursement (P < .001). Similar results were found for prescription fills at all distances, but inpatient encounters remained generally unaffected.Conclusions: Our results suggest that this policy change was successful in increasing access to VA care for patients regardless of location of residence.
Differences in Late‐Stage Diagnosis, Treatment, and Colorectal Cancer‐Related Death Between Rural and Urban African Americans and Whites in Georgia
Authors: Hines Robert B. , Markossian Talar W. 
Published: September 2011

AbstractPurpose: Disparities in health outcomes due to a diagnosis of colorectal cancer (CRC) have been reported for a number of demographic groups. This study was conducted to examine the outcomes of late‐stage diagnosis, treatment, and cancer‐related death according to race and geographic residency status (rural vs urban).Methods: This study utilized cross‐sectional and follow‐up data from the Surveillance, Epidemiology, and End Results (SEER) Program for all incident colon and rectal tumors diagnosed for the Atlanta and Rural Georgia Cancer Registries for the years 1992‐2007.Findings: Compared to whites, African Americans had a 40% increased odds (OR, 1.40; 95% CI, 1.30‐1.51) of late‐stage diagnosis, a 50% decreased odds (OR, 0.50; 95% CI, 0.37‐0.68) of having surgery for colon cancer, and a 67% decreased odds (OR, 0.33; 95% CI, 0.25‐0.44) of receiving surgery for rectal cancer. Rural residence was not associated with late stage at diagnosis or receipt of treatment. African Americans had a slightly increased risk of death from colon cancer (HR, 1.11; 95% CI, 1.00‐1.24) and a larger increased risk of death due to rectal cancer (HR, 1.24; 95% CI, 1.14‐1.35). Rural residents experienced a 15% increased risk of death (HR, 1.15; 95% CI, 1.01‐1.32) due to colon cancer.Conclusions: Further investigations should target African Americans and rural residents to gain insight into the etiologic mechanisms responsible for the poorer CRC outcomes experienced by these 2 segments of the population.
Cell‐type Selective Phototoxicity Achieved with Chlorophyll‐a Derived Photosensitizers in a Co‐culture System of Primary Human Tumor and Normal Lung Cells
Authors: Tracy Erin C. , Bowman Mary J. , Pandey Ravindra K. , Henderson Barbara W. , Baumann Heinz 
Published: September 2011

AbstractThe ATP‐dependent transporter ABCG2 exports certain photosensitizers (PS) from cells, implying that the enhanced expression of ABCG2 by cancer cells may confer resistance to photodynamic therapy (PDT) mediated by those PS. In 35 patient‐derived primary cultures of lung epithelial and stromal cells, PS with different subcellular localization and affinity for ABCG2 displayed cell‐type specific retention both independent and dependent on ABCG2. In the majority of cases, the ABCG2 substrate 2‐[1‐hexyloxyethyl]‐2‐devinyl pyropheophorbide‐a (HPPH) was lost from fibroblastic cells more rapidly than from their epithelial counterparts, even in the absence of detectable ABCG2 expression, facilitating selective eradication by PDT of epithelial over fibroblastic cells in tumor/stroma co‐cultures. Pairwise comparison of normal and transformed epithelial cells also identified tumor cells with elevated or reduced retention of HPPH, depending on ABCG2. Enhanced ABCG2 expression led to the selective PDT survival of tumor cells in tumor/stroma co‐cultures. This survival pattern was reversible through HPPH derivatives that are not ABCG2 substrates or the ABCG2 inhibitor imatinib mesylate. PS retention, not differences in subcellular distribution or cell signaling responses, was determining cell type selective death by PDT. These data suggest that up‐front knowledge of tumor characteristics, specifically ABCG2 status, could be helpful in individualized PDT treatment design.
Nondrug Interventions for Treatment of Hypertension
Authors: Woolf Kevin J. , Bisognano John D. 
Published: September 2011

J Clin Hypertens (Greenwich). 2011;13:829–835. ©2011 Wiley Periodicals, Inc.The treatment of hypertension is no longer limited to the simple prescription of pharmaceuticals. For many patients, maximal medical therapy is insufficient to adequately treat refractory hypertension. In addition, some patients may prefer to explore therapies that do not involve drugs as an initial step. Utilizing our broadening understanding of the physiology of hypertension, new technology and interventions have been developed that allow for treatments that do not rely on medications. In addition, dietary supplements and modification, as well as herbal supplements, may be useful under the right circumstances. Lifestyle modification remains a necessary part of treatment for all patients with hypertension. This article will review the evidence behind some available nondrug interventions for the treatment of hypertension.