bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term administration of morphine specifically alters the level of protein expression in different brain regions and affects the redox state
Authors: Hejnova Lucie , Hronova Anna , Drastichova Zdenka , Novotny Jiri 
Published: April 2024

Abstract
We investigated the changes in redox state and protein expression in selected parts of the rat brain induced by a 4 week administration of morphine (10 mg/kg/day). We found a significant reduction in lipid peroxidation that mostly persisted for 1 week after morphine withdrawal. Morphine treatment led to a significant increase in complex II in the cerebral cortex (Crt), which was accompanied by increased protein carbonylation, in contrast to the other brain regions studied. Glutathione levels were altered differently in the different brain regions after morphine treatment. Using label-free quantitative proteomic analysis, we found some specific changes in protein expression profiles in the Crt, hippocampus, striatum, and cerebellum on the day after morphine withdrawal and 1 week later. A common feature was the upregulation of anti-apoptotic proteins and dysregulation of the extracellular matrix. Our results indicate that the tested protocol of morphine administration has no significant toxic effect on the rat brain. On the contrary, it led to a decrease in lipid peroxidation and activation of anti-apoptotic proteins. Furthermore, our data suggest that long-term treatment with morphine acts specifically on different brain regions and that a 1 week drug withdrawal is not sufficient to normalize cellular redox state and protein levels.
VSP-2 attenuates secretion of inflammatory cytokines induced by LPS in BV2 cells by mediating the PPARγ/NF-κB signaling pathway
Authors: Cui Jingxin , Xu Liwei , Sun Yimeng , Dai Lingfei , Mo Yuxiu , Yun Keli , Chen Yifei , Chen Linglin 
Published: April 2024

Abstract
Neuroinflammation, characterized by microglial activation and the subsequent secretion of inflammatory cytokines, plays a pivotal role in neurodegenerative diseases and brain injuries, often leading to neuronal damage and death. Alleviating neuroinflammation has thus emerged as a promising strategy to protect neurons and ameliorate neurodegenerative disorders. While peroxisome proliferator-activated receptor gamma (PPARγ) agonists have demonstrated potential therapeutic actions on neuroinflammation, their prolonged use, such as with rosiglitazone, can lead to cardiac risks and lipid differentiation disorders. In this study, we investigated the effects of a newly synthesized PPARγ agonist, VSP-2, on secretion of inflammatory cytokines in BV2 cells. Treatment with VSP-2 significantly reduced the mRNA and protein levels of proinflammatory cytokines such as interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α). Furthermore, VSP-2 attenuated the phosphorylation of nuclear factor kappa B (NF-κB) (65 kD) and IκBα, as well as the nuclear translocation of NF-κB (65 kD). Additionally, the use of PPARγ small interfering RNA was able to attenuate the effects of VSP-2 on proinflammatory cytokines and the NF-κB pathway. In conclusion, our findings suggest that VSP-2 effectively suppressed the expressions of IL-1β, IL-6, and TNF-α via the PPARγ/NF-κB signaling pathway. Given its potential therapeutic benefits, VSP-2 may emerge as a promising candidate for the treatment of neurodegenerative diseases or brain injuries associated with neuroinflammation.
Factors influencing spontaneous hypothermia after emergency trauma and the construction of a predictive model
Authors: Feng Xia , Zhu Fangxiang , Qiao Anhua , Li Wenfang , Jiang Ying , Han Zengtao , Dong Lan 
Published: April 2024

Abstract
This study aimed to investigate spontaneous hypothermia among emergency trauma patients and develop a predictive model. A cohort of 162 emergency trauma patients was categorized into hypothermic (n = 61) and control (n = 101) groups, with trauma severity assessed using the modified Glasgow Coma Scale (GCS). Univariate analysis revealed significant differences between the groups in trauma severity, posture, garment wetness, warming measures, pre-hospital fluid resuscitation, and modified GCS scores (P < 0.05). The hypothermic group exhibited lower prothrombin time compared to the control group (P < 0.05). A logistic regression model was constructed, expressed as Y = 25.76 − 1.030X
1 + 0.725X
2 + 0.922X
3 − 0.750X
4 − 0.57X
6, and its fit was evaluated using the Hosmer–Lemeshow test. The receiver operating characteristic curve demonstrated an area under the curve of 0.871, with 81.2% sensitivity and 79.5% specificity. The Youden index identified the optimal predictive cut-off at its highest (0.58). Validation results included 86.21% sensitivity, 82.93% specificity, and 84.29% accuracy. Risk factors for spontaneous hypothermia after emergency trauma encompassed trauma severity, posture during consultation, clothing dampness upon admission, warming measures during transfer, pre-hospital fluid resuscitation, and modified GCS scores. The risk prediction model demonstrated high accuracy, enabling effective assessment of spontaneous hypothermia risk in emergency trauma patients and facilitating preventive measures.
Reference values for plasma and urine trace elements in a Swiss population-based cohort
Authors: Perrais Maïwenn , Trächsel Bastien , Lenglet Sébastien , Pruijm Menno , Ponte Belen , Vogt Bruno , Augsburger Marc , Rousson Valentin , Bochud Murielle , Thomas Aurélien 
Published: April 2024

Abstract

Objectives
Trace elements (TEs) are ubiquitous. TE concentrations vary among individuals and countries, depending on factors such as living area, workplaces and diet. Deficit or excessive TEs concentrations have consequences on the proper functioning of human organism so their biomonitoring is important. The aim of this project was to provide reference values for TEs concentrations in the Swiss population.

Methods
The 1,078 participants to the SKiPOGH cohort included in this study were aged 18–90 years. Their 24-h urine and/or plasma samples were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) to determine 24 TEs concentrations: Ag, Al, As, Be, Bi, Cd, Co, Cr, Cu, Hg, I, Li, Mn, Mo, Ni, Pb, Pd, Pt, Sb, Se, Sn, Tl, V and Zn. Statistical tests were performed to evaluate the influence of covariates (sex, age, BMI, smoking) on these results. Reference intervals for the Swiss adult population were also defined.

Results
TEs concentrations were obtained for respectively 994 and 903 persons in plasma and urine matrices. It was possible to define percentiles of interest (P50 and P95) for almost all the TEs. Differences in TEs distribution between men and women were noticed in both matrices; age was also a cofactor.

Conclusions
This first Swiss biomonitoring of a large TEs-panel offers reference values in plasma and in urine for the Swiss population. The results obtained in this study were generally in line with clinical recommendations and comparable to levels reported in other population-based surveys.
Confounding factors of the expression of mTBI biomarkers, S100B, GFAP and UCH-L1 in an aging population
Authors: Calluy Emma , Beaudart Charlotte , Alokail Majed S. , Al-Daghri Nasser M. , Bruyère Olivier , Reginster Jean-Yves , Cavalier Etienne , Ladang Aurélie 
Published: April 2024

Abstract

Objectives
To evaluate some confounding factors that influence the concentrations of S100 calcium binding protein B (S100B), glial fibrillary acidic protein (GFAP), and ubiquitin carboxyl-terminal hydrolase L-1 (UCH-L1) in older individuals. Indeed, recent guidelines have proposed the combined use of S100B and the “GFAP-UCH-L1” mTBI test to rule out mild traumatic brain injuries (mTBI). As older adults are the most at risk of mTBI, it is particularly important to understand the confounding factors of those mTBI rule-out biomarkers in aging population.

Methods
The protein S100B and the “GFAP and UCH-L1” mTBI test were measured using Liaison XL (Diasorin) and Alinity I (Abbott), respectively, in 330 and 341 individuals with non-suspected mTBI from the SarcoPhAge cohort.

Results
S100B, GFAP and UCH-L1 were all significantly correlated with renal function whereas alcohol consumption, Geriatric Depression Score (GDS), smoking habits and anticoagulant intake were not associated with any of these three biomarkers. Body mass index (BMI) and age were associated with GFAP and UCH-L1 expression while sex and mini-mental state examination (MMSE) were only associated with GFAP. According to the manufacturer’s cut-offs for mTBI rule-out, only 5.5 % of participants were positive for S100B whereas 66.9 % were positive for the “GFAP-UCH-L1” mTBI test. All positive “GFAP-UCH-L1” mTBI tests were GFAP+/UCH-L1-. Among individuals with cystatin C>1.55 mg/L, 25 % were positive for S100B while 90 % were positive for the mTBI test.

Conclusions
Our data show that confounding factors have different impacts on the positivity rate of the “GFAP-UCH-L1” mTBI test compared to S100B.
Development of a disease-based hospital-level diagnostic intensity index
Authors: Ellenbogen Michael I. , Feldman Leonard S. , Prichett Laura , Zhou Junyi , Brotman Daniel J. 
Published: April 2024

Abstract

Objectives
Low-value care is associated with increased healthcare costs and direct harm to patients. We sought to develop and validate a simple diagnostic intensity index (DII) to quantify hospital-level diagnostic intensity, defined by the prevalence of advanced imaging among patients with selected clinical diagnoses that may not require imaging, and to describe hospital characteristics associated with high diagnostic intensity.

Methods
We utilized State Inpatient Database data for inpatient hospitalizations with one or more pre-defined discharge diagnoses at acute care hospitals. We measured receipt of advanced imaging for an associated diagnosis. Candidate metrics were defined by the proportion of inpatients at a hospital with a given diagnosis who underwent associated imaging. Candidate metrics exhibiting temporal stability and internal consistency were included in the final DII. Hospitals were stratified according to the DII, and the relationship between hospital characteristics and DII score was described. Multilevel regression was used to externally validate the index using pre-specified Medicare county-level cost measures, a Dartmouth Atlas measure, and a previously developed hospital-level utilization index.

Results
This novel DII, comprised of eight metrics, correlated in a dose-dependent fashion with four of these five measures. The strongest relationship was with imaging costs (odds ratio of 3.41 of being in a higher DII tertile when comparing tertiles three and one of imaging costs (95 % CI 2.02–5.75)).

Conclusions
A small set of medical conditions and related imaging can be used to draw meaningful inferences more broadly on hospital diagnostic intensity. This could be used to better understand hospital characteristics associated with low-value care.
Two Tales of the Energy Commons Through the Lens of Complexity
Authors: Hoops Björn 
Published: April 2024

Abstract
The Energy Commons embody the small-scale generation of renewable energy by groups of citizens. Existing scholarship and the European Union’s rules on the internal governance of citizen and renewable energy communities envision the Energy Commons as making the energy transition more democratic, equitable, inclusive, and local. Based on empirical research on citizen-led energy generation in Germany, this contribution examines the extent to which Energy Commons in practice live up to these normative ideals, why they partially fail to do so and how regulatory change can enable Energy Commons to converge to these ideals. This contribution sets out different types of Energy Commons and assesses how each type performs against scholarly expectations and the EU rules on their internal governance. It identifies the complexity of the energy sector as the main obstacle to achieving said normative ideals and sketches guidelines for regulatory change to reduce this complexity.
Dysmenorrhea in Tunisian high school adolescent girls: frequency, effects, and absence from school
Authors: Bannour Badra , Rouis Nour , Bannour Rania , Alouane Chourouk , Saadouli Souhir , Bannour Imen 
Published: April 2024

Abstract

Objectives
Dysmenorrhea is a known phenomenon and not just recently, and investigations conducted recently have shown that female adolescents are very susceptible to this condition. Our goal is to determine the prevalence of dysmenorrhea in Tunisia, its risk factors, its impact on truancy rates, and the therapeutic attitudes of girls attending high school about this illness using an epidemiological survey.

Methods
This eight-month study, which spans from October 2022 to May 2023, focuses on 160 high school girls between the ages of 13 and 21. It is a transversal descriptive study. The required data is gathered through the distribution of a self-administered questionnaire.

Results
The mean age of female adolescent participants is 16.44 years and 68 % of them reported dysmenorrhea. The most common symptoms of the pain were headaches (40.0 %). There is a notable prevalence of absenteeism during the menstrual cycle. There seems to be a trend toward self-medication.

Conclusions
In Tunisia, primary dysmenorrhea is a common cause of school absenteeism among female adolescents. Girls’ attitudes toward dysmenorrhea indicate a lack of knowledge, which is why it is crucial for midwives and physicians to educate teenage girls about the condition.
From Below, to Inclusion, Through Transformation: Urban Theology in the Twenty-First Century
Authors: Huotari Rosa , Grönlund Henrietta 
Published: April 2024

Abstract
Urban theology is an enduring theme in scholarly literature, yet to our knowledge, no comprehensive reviews have been carried out on its recent developments. To answer this shortcoming, we present a systematic literature review on the following question: “How is urban theology understood in Western academic literature published in English in the twenty-first century?” We present the 29 research outputs yielded from our review and findings of a thematic content analysis. The findings propose three main themes: 1) Theological rootedness, 2) Societal rootedness, and 3) Reforming urban theology. Through these themes, urban theology emerges as an intertwining research of theology and society that includes both reflection and praxis. It aims to understand and diagnose the city as a place and space through theological reflection and doing theology, and vice versa; to transform the way and content of (doing) theology through the engaged analysis of urban society. Urban theology is done for, by, and within individuals and communities of the urbanized planet holistically, whereby it emerges as theology “from below.” It distinguishes itself from the urban theology of the last century, highlighting the critical need for inclusion and reflexivity in the emerging context and the positionality of the researcher.
A decade development of lipase catalysed synthesis of acylglycerols using reactors: a systematic review
Authors: Abd Razak Nurul Nadiah , Cognet Patrick , Pérès Yolande , Aroua Mohamed Kheireddine , Gew Lai Ti 
Published: April 2024

Abstract
Glycerol esterification produces a variety of valuable chemicals and has been a subject of great interest in recent years. Lipase-catalysed synthesis of acylglycerols reactions have many potential applications, including in the production of structured lipids, biofuels and pharmaceuticals. It offers several benefits over traditional chemical methods, including higher selectivity, milder reaction conditions and increased sustainability. In this systematic review, we summarize 52 primary research of lipase catalysed synthesis of acylglycerol published from 2012 to 2022. Different types of reactions employed in the synthesis of acylglycerols using various lipases are thoroughly discussed. The use of lipase in as biocatalyst in the synthesis of acylglycerols is safe for consumption and sustainable as it can reduce the utilization of toxic and hazardous organic solvents and chemicals that cause harm to human health and the environment. This review serves as a reference for the research and development of acylglycerols using biocatalysts and reactors. It could be an interest to the food and pharmaceutical industries or individuals who are interested to explore this field. Several limitations associated with the overall research on production of acylglycerols are presented in the conclusion section.
The Impact of Remittance Inflows on Inflation: The Case of Lebanon
Authors: Kassab Sara 
Published: April 2024

Abstract
This paper investigates the impact of workers’ remittance inflows on inflation in Lebanon. The data used is monthly data spanning the period from December 2007 to May 2019. I estimate a structural vector autoregressive model using 24 monthly lags and find that a one-time remittance growth shock leads to a statistically significant increase in the inflation rate in the short run in Lebanon. Also, the results show that a remittance growth shock makes a considerable contribution to the forecast error variance for the inflation rate in Lebanon.
narración deconstruida: un contexto de investigación para el aprendizaje artístico a partir de técnicas de simulacro
Authors: González Agudo Iluminada , García Roldán Ángel 
Published: April 2024

Este artículo se centra en la contribución de nuevas estrategias para la descodificación de la información visual. Puesto que las circunstancias actuales comprenden una democratización de la imagen y su problemático dogmatismo como documento informativo, planteamos el trabajo en torno a un medio de alfabetización visual, extensamente explotado a mediados del siglo XX por su implementación narrativo-visual en el ámbito de la industria cultural del momento (la fotonovela) y recuperando con ello este formato editorial para su tratamiento didáctico en torno a la creación de narrativas visuales con distintos fines educativos.

Desde nuestro enfoque, las aplicaciones de los nuevos dispositivos telefónicos son también un instrumento competente que ha de incluirse en el contexto de una educación artística contemporánea. Este planteamiento supera el propio medio y nos aproxima a nuevas consideraciones artístico-sociales, entre otras el fenómeno de la posfotografía, que nos obliga a analizar nuevos espacios de interrelación y mediación educativa y aprendizaje artístico.
Por lo tanto, este trabajo recapitula una experiencia educativa que plantea una re-interpretación de la identidad a través del hecho fotográfico actual, ante la exposición a las diversas formas de simulacro, subyacente en la cultura contemporánea, con el objetivo de activar nuevas estrategias para la deconstrucción de la iconosfera, personal y colectiva.
Diyabetik ayak yarası iyileşmeside plantago majör flovonoidlerin etkinliğinin in-silico olarak araştırılması
Authors: Keleş İsmail , Bayrakdar Alpaslan , Olgun Nermin 
Published: April 2024

ÖZET
Diyabet, insülin eksikliğine bağlı olarak tüm dünyada hızla artan kronik bir hastalıktır. Diyabetik ayak ülserleri diyabetin en önemli komplikasyonlarından biridir. Bu yaralar için birçok sentetik ve doğal tedavi yöntemi bulunmaktadır. Sentetik ilaçların olası yan etkileri arasında quercetin gibi doğal flavonoidlerin kullanımı diyabetik yaraların tedavisinde tercih edilmektedir. Bu çalışmada quercetin'e alternatif olabilecek Plantago major flavonoidleri in-silico olarak araştırılmıştır. Plantago major ve flavonoidlerinin quercetin ile benzer özellikler gösterip göstermediği AutoDockTools yazılımı yardımıyla in-silico olarak araştırılmıştır. Flavonoidlerin ADME çalışması, açık erişimli bir web aracı olan SwissAdme yardımıyla araştırılmıştır. Plantago major flavonoidleri ve quercetin'in diyabetik yara iyileşmesinde rol oynayan SIRT 1 reseptörlerinden biri olan 4ZZJ'nin in-silico çalışmasının sonuçları, Plantago major flovonoidleri luteolin (-4.81 kcal/mol), apigenin (-4.74 kcal/mol) ve hispidulin'in (-4.58 kcal/mol) quarcetin'den (-4.56 kcal/mol) daha iyi olduğunu göstermiştir. Sonuç olarak, bu in-silico çalışma Plantago major flavonoidleriden luteolin, apigenin ve hispidulinin diyabetik yara iyileşmesi için quercetin’e doğal alternatifler olabileceğini göstermiştir.
Effectiveness Counseling Technique Applied Thinking, Feeling, and Acting on Anxiety in Appendicitis Pre-Operating Patients
Authors: Wahyu Purwanza Sena , Priantoro Cesario Tesa , Putra Fetreo Negeo , Rofi'i Muhammad , Erman Wicaksono Kurniawan 
Published: April 2024

Introduction: Anxiety has been studied as the common finding in preoperative patients. For the most recent, nursing interventions aim to reduce anxiety were rely on counseling method. This study aims to determine the effectiveness of counseling applied thinking, feeling dan acting (TFA) on the level of anxiety in appendicitis pre-operative patients.
Method: This study was a Pre experimental one Group Pre-Test and Post Test Design. An Accidental Sampling, was applied to recruit 34 respondents. Data collection using the Anxiety Questionnaire The-Amsterdam Preoperative Anxiety and Information Scale (APAIS) for pretest before treatment with TFA and Post Test after the TFA approach counseling treatment. Data analysis using Statistical Test Paired Sample T-Test to determine the effectiveness of counseling with the TFA approach on reducing anxiety in appendicitis pre-operative patients.

Results: Counseling by approach TFA on the level of anxiety in patients with pre-operation appendicitis with value p=0.000 or p < 0.05 which means it effectively reduces anxiety levels. Counseling applied thinking, feeling, and acting (TFA) effectively reduced the anxiety level of appendicitis pre-operative patients.
Conclusions: Counseling with approach TFA on the level of anxiety in preoperative patients with appendicitis. Patients were able to express their feelings properly, have more rational thinking and prioritize useful actions so that anxiety can be reduced or even eliminated. Further studies should provide a comprehensive assessment of mechanisms anxiety realising in appendicitis pre-operative patients.
An Overview of Quality of Nursing Work-Life In The Inpatient Ward
Authors: Fioren Gabriela , Mustamu Nathania Aurelya , Sahertian Viona Fransin , Patrisia Ineke , Pramusita Santa Maya 
Published: April 2024

Introduction: Quality of nursing work life (QNWL) is the satisfaction of nurses with personal and organizational life, which is gained through working experience to achieve organizational goals. Low QNWL might result in a high willingness to move to another ward or other departments. This study aimed to identify the dimension and quality of nursing work life in the inpatient ward.
Methods: This study was quantitative descriptive, and the population in this study were nurses who worked in the inpatient ward, as much 146 respondents. Total sampling technique used in this study. The data were self-reported and analyzed using univariate tests.
Results: The results also showed that most respondents (96.6%) had a good quality of nursing work life. The dimensions of work life/ home life have a good category (97.9% of respondents). Most of the work design dimension respondents are in a good category (79.7% of respondents). In the work context dimension, almost all respondents were in a good category as much as 97.9%. Meanwhile, in the work world dimension, 85.6% of respondents were in the good category.
Conclusions: The results of the study obtained an overview of the QNWL in a private hospital in western Indonesia. Almost all respondents reported the QNWL was in a good category. This study underlines the highest dimension of QNWL, the strongest impact on job satisfaction. Future researchers can identify the quality of work life of nurses in a wider scope in other clinical settings.