bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-eluting bead transarterial chemoembolization as neoadjuvant therapy pre-liver transplantation for advanced-stage hepatocellular carcinoma
Authors: Ye Zhao-Dan , Zhuang Li , Song Meng-Chen , Yang Zhe , Zhang Wu , Zhang Jing-Feng , Cao Guo-Hong 
Published: June 2024

BACKGROUND
The objectives of this study were to assess the safety and efficacy of drug-eluting bead transarterial chemoembolization (DEB-TACE) as neoadjuvant therapy before liver transplantation (LT) for advanced-stage hepatocellular carcinoma (HCC) and to analyze the prognostic factors.
AIM
To determine whether DEB-TACE before LT is superior to LT for advanced-stage HCC.
METHODS
A total of 99 individuals diagnosed with advanced HCC were studied retrospectively. The participants were categorized into the following two groups based on whether they had received DEB-TACE before LT: DEB-TACE group (n = 45) and control group (n = 54). The participants were further divided into two subgroups based on the presence or absence of segmental portal vein tumor thrombus (PVTT). The DEB-TACE group consisted of two subgroups: Group A (n = 31) without PVTT and group B (n = 14) with PVTT. The control group also had two subgroups: Group C (n = 37) without PVTT and group D (n = 17) with PVTT. Data on patient demographics, disease characteristics, therapy response, and adverse events (AEs) were collected. The overall survival (OS) and recurrence-free survival (RFS) rates were assessed using Kaplan-Meier curves. Univariate and multivariate Cox regression analyses were conducted to determine the parameters that were independently related to OS and RFS.
RESULTS
The DEB-TACE group exhibited an overall response rate of 86.6%. Following therapy, there was a significant decrease in the median alpha-fetoprotein (AFP) level (275.1 ng/mL vs 41.7 ng/mL, P < 0.001). The main AE was post-embolization syndrome. The 2-year rates of RFS and OS were significantly higher in the DEB-TACE group than in the control group (68.9% vs 38.9%, P = 0.003; 86.7% vs 63.0%, P = 0.008). Within the subgroups, group A had higher 2-year rates of RFS and OS compared to group C (71.0% vs 45.9%, P = 0.038; 83.8% vs 62.2%, P = 0.047). The 2-year RFS rate of group B was markedly superior to that of group D (64.3% vs 23.5%, P = 0.002). Results from multivariate analyses showed that pre-LT DEB-TACE [hazard ratio (HR) = 2.73, 95% confidence interval (CI): 1.44-5.14, P = 0.04], overall target tumor diameter ≤ 7 cm (HR = 1.98, 95%CI: 1.05-3.75, P = 0.035), and AFP level ≤ 400 ng/mL (HR = 2.34; 95%CI: 1.30-4.19, P = 0.009) were significant risk factors for RFS. Additionally, pre-LT DEB-TACE (HR = 3.15, 95%CI: 1.43-6.96, P = 0.004) was identified as a significant risk factor for OS.
CONCLUSION
DEB-TACE is a safe and efficient therapy for advanced-stage HCC and also enhances patient survival after LT.
Prediction of pathological complete response and prognosis in locally advanced rectal cancer
Authors: Xu Yi-Jun , Tao Dan , Qin Song-Bing , Xu Xiao-Yan , Yang Kai-Wen , Xing Zhong-Xu , Zhou Ju-Ying , Jiao Yang , Wang Li-Li 
Published: June 2024

BACKGROUND
Colorectal cancer is currently the third most common malignant tumor and the second leading cause of cancer-related death worldwide. Neoadjuvant chemoradiotherapy (nCRT) is standard for locally advanced rectal cancer (LARC). Except for pathological examination after resection, it is not known exactly whether LARC patients have achieved pathological complete response (pCR) before surgery. To date, there are no clear clinical indicators that can predict the efficacy of nCRT and patient outcomes.
AIM
To investigate the indicators that can predict pCR and long-term outcomes following nCRT in patients with LARC.
METHODS
Clinical data of 128 LARC patients admitted to our hospital between September 2013 and November 2022 were retrospectively analyzed. Patients were categorized into pCR and non-pCR groups. Univariate analysis (using the χ 2 test or Fisher’s exact test) and logistic multivariate regression analysis were used to study clinical predictors affecting pCR. The 5-year disease-free survival (DFS) and overall survival (OS) rates were calculated using Kaplan-Meier analysis, and differences in survival curves were assessed with the log-rank test.
RESULTS
Univariate analysis showed that pretreatment carcinoembryonic antigen (CEA) level, lymphocyte-monocyte ratio (LMR), time interval between neoadjuvant therapy completion and total mesorectal excision, and tumor size were correlated with pCR. Multivariate results showed that CEA ≤ 5 ng/mL (P = 0.039), LMR > 2.73 (P = 0.023), and time interval > 10 wk (P = 0.039) were independent predictors for pCR. Survival analysis demonstrated that patients in the pCR group had significantly higher 5-year DFS rates (94.7% vs 59.7%, P = 0.002) and 5-year OS rates (95.8% vs 80.1%, P = 0.019) compared to the non-pCR group. Tumor deposits (TDs) were significantly correlated with shorter DFS (P = 0.002) and OS (P < 0.001).
CONCLUSION
Pretreatment CEA, LMR, and time interval contribute to predicting nCRT efficacy in LARC patients. Achieving pCR demonstrates longer DFS and OS. TDs correlate with poor prognosis.
Epidemiology and prognostic nomogram for locally advanced gastric signet ring cell carcinoma: A population-based study
Authors: Yu Ze-Hao , Zhang Lei-Ming , Dai Zhi-Qi , Zhang Meng-Na , Zheng Si-Ming 
Published: June 2024

BACKGROUND
Gastric signet ring cell carcinoma (GSRC) represents a specific subtype of gastric cancer renowned for its contentious epidemiological features, treatment principles, and prognostic factors.
AIM
To investigate the epidemiology of GSRC and establish an improved model for predicting the prognosis of patients with locally advanced GSRC (LAGSRC) after surgery.
METHODS
The annual rates of GSRC incidence and mortality, covering the years 1975 to 2019, were extracted from the Surveillance, Epidemiology, and End Results (SEER) database to explore the temporal trends in both disease incidence and mortality rates using Joinpoint software. The clinical data of 3793 postoperative LAGSRC patients were collected from the SEER database for the analysis of survival rates. The Cox regression model was used to explore the independent prognostic factors for overall survival (OS). The risk factors extracted were used to establish a prognostic nomogram.
RESULTS
The overall incidence of GSRC increased dramatically between 1975 and 1998, followed by a significant downward trend in incidence after 1998. In recent years, there has been a similarly optimistic trend in GSRC mortality rates. The trend in GSRC showed discrepancies based on age and sex. Receiver operating characteristic curves, calibration curves, and decision curve analysis for 1-year, 3-year, and 5-year OS demonstrated the high discriminative ability and clinical utility of this nomogram. The area under the curve indicated that the performance of the new model outperformed that of the pathological staging system.
CONCLUSION
The model we established can aid clinicians in the early prognostication of LAGSRC patients, resulting in improved clinical outcomes by modifying management strategies and patient health care.
Visualization analysis of research hotspots and trends on gastrointestinal tumor organoids
Authors: Wang Gang , Liu Tao , He Wen-Ting 
Published: June 2024

BACKGROUND
Gastrointestinal tumor organoids serve as an effective model for simulating cancer in vitro and have been applied in basic biology and preclinical research. Despite over a decade of development and increasing research achievements in this field, a systematic and comprehensive analysis of the research hotspots and future trends is lacking.
AIM
To address this problem by employing bibliometric tools to explore the publication years, countries/regions, institutions, journals, authors, keywords, and references in this field.
METHODS
The literature was collected from Web of Science databases. CiteSpace-6.2R4, a widely used bibliometric analysis software package, was used for institutional analysis and reference burst analysis. VOSviewer 1.6.19 was used for journal co-citation analysis, author co-authorship and co-citation analysis. The ‘online platform for bibliometric analysis (https://bibliometric.com/app )’ was used to assess the total number of publications and the cooperation relationships between countries. Finally, we employed the bibliometric R software package (version R.4.3.1) in R-studio, for a comprehensive scientific analysis of the literature.
RESULTS
Our analysis included a total of 1466 publications, revealing a significant yearly increase in articles on the study of gastrointestinal tumor organoids. The United States (n = 393) and Helmholtz Association (n = 93) have emerged as the leading countries and institutions, respectively, in this field, with Hans Clevers and Toshiro Sato being the most contributing authors. The most influential journal in this field is Gastroenterology. The most impactful reference is "Long term expansion of epithelial organs from human colon, adenoma, adenocarcinoma, and Barrett's epithelium". Keywords analysis and citation burst analysis indicate that precision medicine, disease modeling, drug development and screening, and regenerative medicine are the most cutting-edge directions. These focal points were further detailed based on the literature.
CONCLUSION
This bibliometric study offers an objective and quantitative analysis of the research in this field, which can be considered as an important guide for next scientific research.
Impact of index admission cholecystectomy vs interval cholecystectomy on readmission rate in acute cholangitis: National Readmission Database survey
Authors: Sohail Abdullah , Shehadah Ahmed , Chaudhary Ammad , Naseem Khadija , Iqbal Amna , Khan Ahmad , Singh Shailendra 
Published: June 2024

BACKGROUND
Elective cholecystectomy (CCY) is recommended for patients with gallstone-related acute cholangitis (AC) following endoscopic decompression to prevent recurrent biliary events. However, the optimal timing and implications of CCY remain unclear.
AIM
To examine the impact of same-admission CCY compared to interval CCY on patients with gallstone-related AC using the National Readmission Database (NRD).
METHODS
We queried the NRD to identify all gallstone-related AC hospitalizations in adult patients with and without the same admission CCY between 2016 and 2020. Our primary outcome was all-cause 30-d readmission rates, and secondary outcomes included in-hospital mortality, length of stay (LOS), and hospitalization cost.
RESULTS
Among the 124964 gallstone-related AC hospitalizations, only 14.67% underwent the same admission CCY. The all-cause 30-d readmissions in the same admission CCY group were almost half that of the non-CCY group (5.56% vs 11.50%). Patients in the same admission CCY group had a longer mean LOS and higher hospitalization costs attributable to surgery. Although the most common reason for readmission was sepsis in both groups, the second most common reason was AC in the interval CCY group.
CONCLUSION
Our study suggests that patients with gallstone-related AC who do not undergo the same admission CCY have twice the risk of readmission compared to those who undergo CCY during the same admission. These readmissions can potentially be prevented by performing same-admission CCY in appropriate patients, which may reduce subsequent hospitalization costs secondary to readmissions.
Possibilities for Using E-Modules in Vocational High Schools to Facilitate Critical Thinking Skills
Authors: Fitriana Eka , Djono Djono , Sumaryati Sri 
Published: June 2024

Objective: Critical thinking as part of the competency tools for 21st-century positions has a strategy at the Vocational high school in preparing graduates who are competent, ready to work, and have communication and collaboration skills. However, learning media use still needs to be optimal for teachers to support classroom learning to increase students' understanding and facilitate critical thinking skills in the learning process. Therefore, it is necessary to improve the learning system because these problems must provide students with a better learning experience. The research aims to determine students' perceptions regarding opportunities for developing e-modules based on problem-based learning to facilitate critical thinking skills in accounting learning material. Method: Descriptive qualitative, using research instruments like interviews and questionnaires. The research participants were 45 students specializing in accounting. The research results showed that students are very familiar with using digital media, and most students said that learning with digital learning media gave an interesting learning impression. Results: are great opportunities for developing e-modules that students can use for independent learning flexibly. Novelty: E-modules integrated with problem-based learning models aim to empower students' critical thinking skills, especially in accounting material.
Neurotoxin-induced animal model of multiple sclerosis: Molecular mechanism focus
Authors: Permana Yandi , Siswanto Soni , Aziz Nur Hidayah Kaz Abdul , Wardhani Bantari Wisynu Kusuma 
Published: June 2024

Background: Neurotoxins can alter the central nervous system. They induce severe clinical symptoms such as encephalopathy, convulsions, muscle paralysis, and respiratory failure. Hence, the neurotoxin can mimic human central nervous system disorders such as Multiple Sclerosis (MS) to study pathophysiology and drugs of development.
Objective: This mini-review compared the neurotoxins for mimicking MS in animal models.
Method: This study was a narrative review using the scientific electronic databases Scopus, PubMed, and Google Scholar. All related articles by keywords animal models, multiple sclerosis, and neurotoxins were collected by YP and BW. All authors contributed to manuscript development.
Result: Cuprizone, ethidium bromide, lysolecithin, Myelin Oligodendrocyte Glycoprotein (MOG), and Myelin Essential Protein (MBP) are neurotoxins for MS animal models. Cuprizone is particularly relevant for use in studies addressing toxic mechanisms of the demyelination process and studies of therapeutic interventions. Ethidium bromide causes spinal cord demyelination with distinctive features in the oligodendrocytes and astrocytes. However, it is a carcinogen agent. Lysolecithin is suitable for old animal models because the duration for remyelination is relatively longer than others. MOG and MBP are preferable to resemble MS pathophysiology in humans.
Conclusion: MOG and MBP are appropriate for generating animal multiple sclerosis models for further in vivo experiments.
Isolation of Lactobacillus plantarum CMT1 from shrimp intestine and its effects on growth and survival of the whiteleg shrimp, Litopeneaus vannamei
Authors: Phan Thi Cam Tu , Nguyen Thi Thu , Nguyen Thi Kim Lien , Huynh Truong Giang , Tran Thi Thanh Hien 
Published: June 2024

Probiotics are widely applied in aquaculture, which can improve the growth, survival and health of aquatic animals. The aim of this study was to isolate and evaluate a Lactobacillus strain from the intestine of healthy whiteleg shrimp, Litopenaeus vannamei. A total of 20 Lactobacillus isolates showed rod-shaped morphology, gram-positive, non-motile, non-spore forming, and catalase and oxidase negative. Among the isolates, strain CMT1 exhibited the highest antibacterial activity against Vibrio parahaemolyticus and extracellular enzyme activity, which was selected and identified as Lactobacillus plantarum CMT1 based on 16S rDNA gene sequencing. This strain was also chosen to evaluate its effects on growth and survival of the whiteleg shrimp as a feed supplement. Four different diets were prepared, including the control (a commercial diet without L. plantarum CMT1) and three different concentrations of L. plantarum CMT1, viz. T1 (106 CFU kg diet-1), T2 (107 CFU kg diet-1), and T3 (108 CFU kg diet-1). After a 56-day feeding trial, the growth parameters in the T3 group had the highest values and showed a significant difference compared to the other groups. The survival rates of shrimp fed T2 and T3 diets were significantly higher than those in the control diet (p < 0.05). The lowest FCR value was recorded in the T3 group and showed a significant difference compared to the control group (p < 0.05). In addition, Lactobacillus counts in T2 and T3 groups increased significantly from day 28, which indicated that L. plantarum CMT1 could sustain its population in the intestine of shrimp. However, the total Vibrio sp. count in the T2 and T3 groups was significantly lower than that in the control group (p < 0.05). In conclusion, L. plantarum CMT1 could be used as a potential probiotic for shrimp aquaculture, and the recommended level of the probiotic strain CMT1 is 108 CFU kg diet-1.
JAMOVI COMO HERRAMIENTA PARA EL ANÁLISIS DE DATOS EN LA ASIGNATURA DE ESTADÍSTICA Y DISEÑO DE EXPERIMENTOS
Authors: Lino Victor , Carvajal Rivadeneira Daniel David , Muñoz Zambrano Jaime Leonel , Intriago Delgado Yandry Marcelo 
Published: June 2024

En la asignatura Estadística y Diseño de Experimentos de la Maestría en Planificación de Infraestructuras Física de Obras Civiles de la Universidad Estatal del Sur de Manabí (UNESUM), se pretende fomentar un enfoque holístico en donde se conjugan la parte teórica y la práctica. Este estudio, se realiza por la necesidad imperante de modernizar las prácticas educativas y profesionales en estadística y diseño de experimentos. La investigación tiene como objetivo evaluar la eficacia de Jamovi como herramienta para el análisis de datos. La metodología adoptada se configura como observacional, de corte transversal y analítica. En este trabajo se incluye la revisión de informes de investigación de los estudiantes de la primera cohorte, además se diseñó una lista de cotejo para evaluar aspectos claves del uso de Jamovi, y la aplicación de enfoques teóricos como el analítico-sintético e inductivo-deductivo. Los participantes destacan la capacidad de la herramienta para simplificar el análisis estadístico, mejorar la interpretación de resultados descriptivos y facilitar la aplicación de pruebas de hipótesis. En la conclusión, se destaca la importancia estratégica de adoptar herramientas modernas y accesibles, como Jamovi. Con ello se prepara a los estudiantes para enfrentar desafíos analíticos futuros en la planificación de infraestructuras físicas de obras civiles y responde a la creciente necesidad de adaptarse a un entorno tecnológico en constante evolución. La investigación aboga por la integración de herramientas de este tipo en el ámbito educativo, destacando su papel en la optimización de procesos analíticos y la formación de profesionales capacitados.
Peran International Civil Aviation Organization (ICAO) Dalam Penanganan Kasus-Kasus Penembakan Pesawat Sipil Di Wilayah Berkonflik
Authors: Simamora Rumla Yanti , Lestari Maria Maya 
Published: June 2024

Introduction: The International Civil Aviation Organization (ICAO) acts as an organization that notifies civilian aircraft that will pass in conflict areas and also cooperates with other countries in increasing ICAO supervision so that similar cases do not occur.
Purposes of the Research: To know the role of ICAO (International Civil Aviation Organization) in handling international aviation safety supervision and cases of shooting down civil aircraft in conflict areas.
Methods of the Research: This type of research can be classified as a normative research type, this research uses research methods on the principles of international law. This research is a descriptive analysis, namely describing and analyzing the problems that have been put forward to describe an overview of the International Civil Aviation Organization in handling cases of shooting down civil aircraft in conflict areas related to international air law.
Results of the Research: International civil aviation, especially when crossing conflict zones while the Civil Aviation Convention (known as the Chicago Convention) establishes a framework for civil aviation investigations, does not provide an appropriate legal and institutional framework for accountability, ICAO's role as a specialized agency of the United Nations which is required from time to time to refrain from violations. International political parameters in its diplomatic efforts
Kekuataan Hukum Perjanjian Lisan Antara Agen Kelapa Sawit Dengan Petani
Authors: Sihite Sri Rumada , Sinaga Roulinta Yesvery 
Published: June 2024

Introduction: Oral agreements that occur between oil palm farmers and oil palm agents where the agreement is buying and selling oil palm orally. However, there is a problem where the palm oil agent turns out to be in default. This writing is to examine the oral agreement between oil palm agents and oil palm farmers in Teluk Dalam Village.
Purposes of the Research: The purpose of this research is to know the legal force of oral agreements between oil palm agents and oil palm farmers in the village of Teluk Pulai.
Methods of the Research: The research method is normative juridical with the type of library research and field data.
Results Originality of the Research: The results of the oral agreement on the sale of oil palm between the oil palm agent and the oil palm grower which of course this is considered valid due to the fulfillment of the elements and conditions that have been determined. The agreement made must be serious, in good faith and know the provisions of the object, price and capacity between the parties, it is necessary for the parties to comply with these provisions to ensure the validity and enforceability of the sale and purchase agreement in the context of civil law in Indonesia.
Akibat Hukum Wanprestasi Atas Perjanjian Lisan Pinjam-Meminjam Oleh Pasangan Kekasih Yang Tidak Terikat Perkawinan
Authors: Panjaitan Wijaya Natalia 
Published: June 2024

Introduction: Verbal agreements to borrow stuff and/or money are often made by couples who are not bound by marriage in their daily relationship activities. The impact of this verbal agreement often causes legal problems, which is the breach of contract by one of the parties when the relationship between the couple does not continue to the level of marriage, causing material and immaterial losses to the other party.
Purposes of the Research: The purpose of this research is to find out the legal consequences of a breach of the verbal agreement of lending and borrowing by a spouse who is not bound by marriage.
Methods of the Research: The research method used is normative juridical research with the type of library research.
Results Originality of the Research: The legal consequences of a breach of the verbal lending and borrowing agreement are material and immaterial losses so that a claim for compensation can be filed by filing a lawsuit for breach of contract with the Civil Court.