bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revisiting the Efficacy of Sumatriptan Therapy During the Aura Phase of Migraine
Authors: Aurora Sheena K. , Barrodale Patricia M. , McDonald Susan A. , Jakubowski Moshe , Burstein Rami 
Published: April 2009

Objective.— To reexamine the efficacy of terminating migraine headache by administration of sumatriptan during the visual‐aura phase of the attack.Background.— Although the antimigraine action of triptans is most effective soon after onset of the headache, treatment during the aura phase has been found to be ineffective.Methods.— Nineteen subjects having migraine with aura were studied using a 4‐way crossover, open‐label design. Each patient was asked to treat 8 consecutive attacks with 100 mg of sumatriptan RT: 3 attacks treated at a timing of the patient's discretion (baseline); 1 attack treated 4 hours after onset of pain (late); 2 attacks treated within 1 hour of onset of pain (early); 2 attacks treated during the aura phase – before the onset of pain (aura). Pain level and cutaneous allodynia were reported by the patients at the onset of pain, at the time of treatment, and 2 and 24 hours after treatment.Results.— Sumatriptan treatment during the aura preempted the development of headache in 34/38 (89%) attacks. The same patients were rendered pain‐free in 30/38 (79%) of attacks treated within 1 hour of pain onset, and in 4/19 (21%) of attacks treated 4 hours after the onset of pain. The incidence of allodynia at the time of treatment was 2/38 (5%) in attacks treated during aura, 8/38 (21%) in attacks treated early, and 14/19 (74%) in attacks treated late.Conclusion.— Considering the discrepancy between the present and previous clinical studies, it is worthwhile revisiting the efficacy of preemptive triptan therapy during the aura phase of migraine attacks, using larger‐scale, 3‐way, crossover, placebo‐controlled studies.
Correlations of Headache Diary Parameters, Quality of Life and Disability Scales
Authors: Hoppe Andrea , Weidenhammer Wolfgang , Wagenpfeil Stefan , Melchart Dieter , Linde Klaus 
Published: April 2009

Objective.— We aimed to investigate (1) to which extent headache diary variables correlate among each other; (2) to which extent they correlate with generic measures of quality of life and disability; (3) and whether correlations vary over time.Methods.— We performed a secondary analysis of data from 301 patients suffering from migraine and 270 patients suffering from tension‐type headache collected in 2 randomized trials of acupuncture. We calculated product–moment correlation coefficients.Results.— Correlations between diary parameters varied to a great extent. Attack frequency, a measure recommended by the International Headache Society as a primary outcome measure for migraine prophylaxis trials, correlated only moderately with other diary outcomes. At baseline the parameters measured in the headache diary correlated only weakly with the generic outcome measures. After 12 weeks these correlations had increased considerably.Conclusion.— Our findings suggest that participants in headache trials “learn” to fill in diaries and generic instruments in a more consistent manner during the course of the study.
Current incidence and residual risk of hepatitis B infection among blood donors in the United States
Authors: Zou Shimian , Stramer Susan L. , Notari Edward P. , Kuhns Mary C , Krysztof David , Musavi Fatemeh , Fang Chyang T. , Dodd Roger Y. 
Published: April 2009

BACKGROUND: This study used two approaches to estimate the current incidence of hepatitis B virus (HBV) in a US donor population.METHODS: HBV incidence was estimated through the hepatitis B surface antigen (HBsAg) yield approach and the seroconversion method. Residual risk was estimated by the incidence–window period model. HBsAg yield refers to an HBsAg confirmed‐positive, antibody against hepatitis B core antigen (anti‐HBc)–nonreactive donation, adjusted for false‐positive neutralization results. The number of HBsAg‐seroconverting repeat donors divided by total number of person‐years of evaluation or the HBsAg yield rate divided by HBsAg yield window gave rise to incidence estimates.RESULTS: The seroconversion and the yield approach, respectively, gave an incidence estimate of 3.41 or 3.43 per 105 person‐years. Using a revised infectious window period of 38 or 30 days for current HBsAg assays, the current residual risk for HBV was respectively estimated for 2006 to 2008 at 1 in 282,000 or 1 in 357,000 donations from the seroconversion approach and 1 in 280,000 or 1 in 355,000 donations from the yield approach. With the same database and methods, this is a decrease from 1 in 86,000 to 1 in 110,000 observed in 1997 to 1999.CONCLUSIONS: Current HBV incidence and residual risk are lower than earlier estimates, especially in the youngest donors, but remain higher in the absence of HBV nucleic acid test than those for human immunodeficiency virus or hepatitis C virus (HCV). In addition to the exclusion of HBsAg false‐positive donors, the reduction could reflect shortened window periods and decreased incidence rates due to vaccination or other reasons.
Evaluation and comparison of coagulation factor activity in fresh‐frozen plasma and 24‐hour plasma at thaw and after 120 hours of 1 to 6°C storage
Authors: Scott Erik , Puca Kathleen , Heraly Jennifer , Gottschall Jerome , Friedman Kenneth 
Published: April 2009

BACKGROUND: Current transfusion‐related acute lung injury reduction strategies include avoiding transfusion of plasma products collected from female donors or female donors that have been pregnant to reduce transfusion of plasma‐containing HLA antibodies. Such a policy considerably decreases the number of donors available for generation of fresh‐frozen plasma (FFP). To increase the supply of FFP, substitution of 24‐hour plasma (FP24) and thawed plasma (TP) derived from either FFP or FP24 may be viable substitutes. To justify such a policy the coagulation factor content of FFP, FP24, and TP derived from both product types was assessed.STUDY DESIGN AND METHODS: Coagulation factor (F)II, FV, FVII, FVIII, F IX, and FX; protein C (PC) and protein S (PS); von Willebrand factor antigen and ristocetin cofactor; fibrinogen; and antithrombin activities were analyzed in nonpaired FFP and FP24 at the time of product thaw and again after 120 hours of 1 to 6°C storage.RESULTS: At thaw, mean FVIII and PC activities were lower in FP24 than FFP. Mean PC and PS activities were lower in FP24‐ than FFP‐derived 120‐hour‐old TP. No other differences in mean activity reached significance. Activity levels were generally lower in TP; FVIII, FV, and FVII showed the largest changes. However, prestorage leukoreduction appears to improve the stability of FV.CONCLUSION: FFP, FP24, and the derived TP all contain adequate coagulation factor activities to maintain hemostatic activity. As FFP becomes less available, increased use of FP24 and TP are viable alternatives for most clinical situations.
Delayed hemolytic transfusion reaction in sickle cell disease patients: evidence of an emerging syndrome with suicidal red blood cell death
Authors: Chadebech Philippe , Habibi Anoosha , Nzouakou Ruben , Bachir Dora , Meunier‐Costes Natacha , Bonin Philippe , Rodet Martine , Chami Btissam , Galacteros Frederic , Bierling Philippe , Noizat‐Pirenne France 
Published: April 2009

BACKGROUND: Delayed hemolytic transfusion reaction (DHTR) is a life‐threatening complication in sickle cell disease (SCD) characterized by recurrence of disease complications, recipient red blood cell (RBC) destruction, and frequently no detectable antibody. Phosphatidylserine (PS) exposure signs suicidal RBC death or eryptosis and is involved in vasoocclusive crisis (VOC).STUDY DESIGN AND METHODS: Transfusion was monitored in 48 SCD patients for up to 20 days. PS exposure was evaluated in vivo on patient RBCs (PS‐RBCs) at five time points and in vitro after incubation of donor RBCs with pretransfusion plasma.RESULTS: Three VOC patients displayed DHTR with recurrent SCD features and no detectable antibody in two cases. In vitro, PS‐RBC percentage was significantly increased by incubating donor RBCs with pretransfusion plasma samples from DHTR patients with no detectable antibody. No such increase was observed with samples from other patients. This result indicates that donor RBCs may be damaged by the environment of SCD patients, increasing the physiologic clearance of apoptotic RBCs. In vivo, PS‐RBC percentage increased in all three cases after destruction of transfused RBCs, indicating that DHTR induces PS‐RBCs and, possibly, subsequent VOC and autologous RBC destruction.CONCLUSION: This study clearly demonstrates that DHTR can occur in the absence of detectable antibody. In these cases, a mechanism of excessive eryptosis is proposed.
The spleen plays a central role in primary humoral alloimmunization to transfused mHEL red blood cells
Authors: Hendrickson Jeanne E. , Saakadze Natia , Cadwell Chantel M. , Upton Jason W. , Mocarski Edward S. , Hillyer Christopher D. , Zimring James C. 
Published: April 2009

BACKGROUND: Several differences exist between antigens on transfused red blood cells (RBCs) and other immunogens, including anatomical compartmentalization. Whereas antigens from microbial pathogens and solid organ transplants drain into local lymph nodes, circulating RBCs remain segregated in the peripheral circulation, where they are consumed by antigen‐presenting cells (APCs) in the spleen and liver. Accordingly, it was hypothesized that the splenic APCs play a central role in primary alloimmunization to transfused RBCs.STUDY DESIGN AND METHODS: Recipient mice were splenectomized and transfused with transgenic RBCs expressing the membrane‐bound hen egg lysozyme (mHEL) model RBC antigen. In some experiments, mHEL‐specific CD4+ T cells were adoptively transferred into recipient mice to allow investigation of helper T‐cell responses. Unmanipulated or sham‐splenectomized mice served as controls. Recombinant murine cytomegalovirus expressing mHEL (mHEL‐MCMV) was used as a control non‐RBC immunogen. Humoral responses were measured by mHEL‐specific enzyme‐linked immunosorbent assay and flow cytometric–based RBC cross‐match.RESULTS: Control animals synthesized detectable anti‐HEL immunoglobulin (Ig)G after a single mHEL RBC transfusion. mHEL‐specific CD4+ T cells underwent robust expansion, and adoptive transfer of CD4+ T cells resulted in a 1000‐fold increase in anti‐HEL IgG. In contrast, minimal anti‐HEL IgG was detectable in splenectomized mice, mHEL‐specific CD4+ T cells did not proliferate, and adoptive transfer did not increase anti‐HEL IgG. However, anti‐HEL IgG response after exposure to mHEL‐MCMV was equivalent in control and splenectomized mice.DISCUSSION: Together, these findings illustrate the distinct properties of transfused RBCs as immunologic stimuli, with the spleen playing a critical role in primary RBC alloimmunization at the level of CD4+ T‐cell activation.
Infantile colic, prolonged crying and maternal postnatal depression
Authors: Vik Torstein , Grote Veit , Escribano Joauqín , Socha Jerzy , Verduci Elvira , Fritsch Michaela , Carlier Clotilde , Kries Rüdiger von , Koletzko Berthold ,   for the European Childhood Obesity Trial Study Group
Published: April 2009

AbstractAim:  To study if infant crying is associated with maternal postnatal depression.Methods:  Data from 1015 mothers and their children participating in a prospective European multicentre study were analysed. Infantile colic and prolonged crying were defined as excessive crying as reported by the mothers 2 and 6 months after delivery, and at the same time the mothers completed the Edinburgh Postnatal Depression Scale (EPDS).Results:  In cross‐sectional analyses, infant crying was associated with high EPDS scores both 2 (OR: 4.4; 95% CI: 2.4–8.2) and 6 months postpartum (OR: 10.8; 95% CI: 4.3–26.9). More than one‐third of the others of infants with prolonged crying had high EPDS scores 6 months postpartum. Longitudinal analyses showed that mothers of infants with colic had increased odds of having high EPDS scores 6 months after delivery even if crying had resolved (OR: 3.7; 95% CI: 1.4–10.1).Conclusion: Both infantile colic and prolonged crying were associated with high maternal depression scores. Most noteworthy, infantile colic at 2 months of age was associated with high maternal depression scores  4 months later.
Relationship between endotracheal tube leakage and under‐reading of tidal volume in neonatal ventilators
Authors: Mahmoud RA , Fischer HS , Proquitté H , Shalaby HM Abudaif , Schmalisch G 
Published: April 2009

AbstractAim:  Protective ventilation in neonates requires careful volume monitoring to prevent ventilator‐induced lung injury caused by baro/volutrauma and hence chronic lung disease. This study investigated the effect of endotracheal tube (ET) leakage on the displayed tidal volume using an in vitro model.Methods:  A neonatal lung model was ventilated via a 3 mm ET using three ventilators [Babylog 8000 (BL), Leoni (LE) and Stephanie (ST)]. Tidal volume was measured by each ventilator at the Y‐piece and by a pneumotach (CO2SMO+) in the model. ET leaks were simulated by open tubes of different lengths. PIP (20 cmH2O) and PEEP (5 cmH2O) were kept constant, and the respiratory rate (RR) was varied between 20/min and 70/min (Ti:Te = 1:1).Results:  Tidal volume displayed by a ventilator decreased independently of RR with increasing leakage up to 21% (BL), 30% (LE) and 33% (ST). However, the volume delivered to the lung was nearly constant. The displayed leakage varied between 0 and 78% and was dependent on RR and leakage resistance. There were distinct differences between the three ventilators in the relationship between displayed leakage and volume error. Accepting a volume error <10% for RR between 20 and 70/min, ET leakage of up to 20% for BL, 12% for LE, but only <5% for ST, was acceptable.Conclusion:  Tidal volume underestimation arising from ET leakage depends on ventilator pressures, timing parameters and ventilator‐specific algorithms for signal processing. Therefore, neonatologists should be aware of these issues to prevent lung over‐inflation when adjusting target volume in the presence of ET leakage.
The Buccofacial Wall of Maxillary Sinus: An Anatomical Consideration for Sinus Augmentation
Authors: Yang Hun‐Mu , Kyong Bae Hanna Eun , Won Sung‐Yoon , Hu Kyung‐Seok , Song Woo‐Chul , Paik Doo‐Jin , Kim Hee‐Jin 
Published: April 2009

ABSTRACTPurpose: This study aimed to quantify the thickness of the buccofacial wall of the maxillary sinus where sinus augmentations are often performed.Materials and Methods: Fourteen sites located 15 and 20 mm superior to the anatomical cervical line (named as groups H15 and H20, respectively) and along the long axes of the mid and the interproximal of two premolars and two molars were measured from 74 Korean hemiface cadavers.Results: The buccofacial wall of the maxillary sinus was thinnest at the area between the maxillary second premolar and first molar in groups H15 and H20. The lowest mean thickness was 1.2 mm in both groups. The walls were thicker in males than in females, with statistically significant gender differences found at four and two sites on the anterior horizontal reference in groups H15 and H20, respectively. However, the thickness did not differ significantly with age or laterality. Incomplete septa were found in seven of the 74 specimens, and they were present in the area between the first and second molars in six (86%) of these cases.Conclusions: These observations indicate that anatomical characteristics of the buccofacial wall thickness of the maxillary sinus need to be considered when performing a window opening procedure for sinus augmentation.
Early Loading of Nonsubmerged Titanium Implants with a Chemically Modified Sand‐Blasted and Acid‐Etched Surface: 6‐Month Results of a Prospective Case Series Study in the Posterior Mandible Focusing on Peri‐Implant Crestal Bone Changes and Implant Stability Quotient (ISQ) Values
Authors: Bornstein Michael M. , Hart Christopher N. , Halbritter Sandro A. , Morton Dean , Buser Daniel 
Published: April 2009

ABSTRACTPurpose:The aim of this prospective case series study was to evaluate the short‐term success rates of titanium screw‐type implants with a chemically modified sand‐blasted and acid‐etched (mod SLA) surface after 3 weeks of healing.Material and Methods:A total of 56 implants were inserted in the posterior mandible of 40 partially edentulous patients exhibiting bone densities of class I to III. After a healing period of 3 weeks, all implants were functionally loaded with a screw‐retained crown or fixed dental prosthesis. The patients were recalled at weeks 4, 7, 12, and 26 for monitoring and assessment of clinical and radiological parameters, including implant stability quotient (ISQ) measurements.Results:None of the implants failed to integrate. However, two implants were considered “spinners” at day 21 and left unloaded for an extended period. Therefore, 96.4% of the inserted implants were loaded according to the protocol tested. All 56 implants including the “spinners” showed favorable clinical and radiographic findings at the 6‐month follow‐up examination. The ISQ values increased steadily throughout the follow‐up period. At the time of implant placement, the range of ISQ values exhibited a mean of 74.33, and by week 26, a mean value of 83.82 was recorded. Based on strict criteria, all 56 implants were considered successfully integrated, resulting in a 6‐month survival and success rate of 100.0%.Conclusion:This prospective study using an early‐loading protocol after 3 weeks of healing demonstrated that titanium implants with the modified SLA surface can achieve and maintain successful tissue integration over a period of at least 6 months. The ISQ method seems feasible to monitor implant stability during the initial wound‐healing period.
Implant Placement in Patients with Oral Bisphosphonate Therapy: A Case Series
Authors: Shabestari Ghasem Omati , Shayesteh Yadollah Soleimani , Khojasteh Arash , Alikhasi Marzieh , Moslemi Neda , Aminian Amin , Masaeli Reza , Eslami Behnam , Treister Nathaniel S. 
Published: April 2009

ABSTRACTBackground: Although the effect of bisphosphonates on dental implant osseointegration is not clear, dental implant failures attributable to oral bisphosphonate therapy have been reported in patients with osteoporosis.Purpose: The aim of this study was to evaluate implant survival in patients with a history of bisphosphonate therapy in a retrospective survey.Materials and Methods: A total of 46 ITI implants placed in 21 osteoporotic patients (females; average age 53 years, range 42–79 years) were evaluated with regard to probing depth, mobility, thread exposure, and bleeding on probing. All patients were under oral bisphosphonate therapy.Results: None of implants showed mobility and all patients could be considered free from peri‐implantitis. Time of bisphosphonate therapy before and after implant insertion showed no statistically significant influence on PD, BOP, and TE. Likewise, implant location, prosthetic type, and opposing dentition had no statistically significant influence on the clinical and radiological parameters of implants.Conclusion: Within the limitations of this study, it could be concluded that neither being on oral bisphosphonate treatment before implant placement nor starting bisphosphonate therapy after implant installation might jeopardize the successful osseointegration and clinical and radiographic condition of the implants.
Bone Structure Changes in Iliac Crest Grafts Combined with Implants
Authors: Verhoeven Jan Willem , Ruijter Jan M. , Koole Ronald , De Putter Cornelis , Cune Marco S. 
Published: April 2009

ABSTRACTBackground: Remodeling of onlay grafts combined with implants to the mandible results in predictable changes in the graft's radiographic density. We studied the relationship between changes in radiographic density and trabecular structure during the first year after onlay grafting with simultaneous implant placement to the mandible.Purpose: The aim of this study was to evaluate changes in bone structure after onlay grafting.Materials and Methods: Standardized extraoral radiographs were taken regularly of 16 mandibular sides. Bone structure was measured using the Carl Zeiss Vision KS 400 3.0 imaging system. The parameters studied were trabecular area and perimeter, cavity area and perimeter, end points, branching points, skeleton length, branch angle and direction, and texture.Results: No differences were found between measurements ventrally versus dorsally of the implant, nor close to versus away from the implant. Early cortical changes suggest partial resorption and formation of a more complex structure. In the fourth quarter after surgery, progressive resorption is seen in the graft's upper cortex. In the graft's upper spongiosa, most parameters indicate bone formation during the first postoperative year. Loading‐induced structure changes could not yet be found.Conclusion: The technique can be used to study changes in the architecture of bone grafts. Changes found in the graft's architecture are in accordance with changes in bone density.
Sexual Dysfunction and Symptom Impact in Men with Long-Standing Type 1 Diabetes in the DCCT/EDIC Cohort
Authors: Penson David F. , Wessells Hunter , Cleary Patricia , Rutledge Brandy N. 
Published: April 2009

ABSTRACT

Introduction
Male sexual dysfunction is a common complication of diabetes (DM), but the relative impact of erectile dysfunction (ED), orgasmic dysfunction (OD), and/or decreased libido (DL) on global sexual bother has not been assessed.

Aim
To assess the relationship between ED, OD, and DL and overall sexual satisfaction in men with type 1 DM, and determine which form of dysfunction causes the most bother.

Methods
The study cohort consisted of 713 men with type 1 DM who completed the Diabetes Control and Complication Trial and then participated in the follow-up Epidemiology of Diabetes Interventions and Complications Study. In year 10 of EDIC, 583 (83%) completed a validated instrument assessing ED, OD, and DL and the bother these conditions cause. Statistical tests determined the concordance of function and bother in each domain, and the impact of each domain on overall sexual satisfaction.

Main Outcome Measures
Patient-reported outcomes using responses to individual items of the International Index of Erectile Function (IIEF).

Results
ED was present in 34%, OD in 20%, and DL in 55%. When correlated with overall sexual satisfaction, ED had the highest weighted kappa (0.84, 95% confidence interval [CI] = 0.80–0.87), while OD (0.57, 95% CI = 0.51–0.63) and DL (0.55, 95%CI = 0.48–0.62) were considerably lower. Furthermore, the single item assessing confidence in getting and keeping an erection had the strongest correlation with overall sexual bother as well as specific erectile bother.

Conclusions
ED, OD, and DL are highly prevalent in men with long-standing type I diabetes. All three sexual dysfunctions cause bother in men with DM, but ED causes more general sexual bother and likely has a greater overall impact on quality of life. Our data underscore the importance of asking men with DM about their sexual function and point to the need for further research to investigate disorders of orgasm and desire.