bluuebunny/crossref_metadata_2025_split huggingface dataset:
Course of brain damage following malignant hypertension
Authors: Liegey Jean Sebastien , cremer antoine , Lucas Ludovic , Gosse Philippe , Debeugny Stephane , Rubin Sebastien , Doublet julien , Sibon Igor , BOULESTREAU ROMAIN 
Published: June 2024

Abstract

Background Malignant hypertension (MHT) crisis is characterized by acute and diffuse microvascular damages, and the brain is a primary target organ. While a recent MRI study has revealed extensive and frequent cerebral injuries during the acute phase of MHT crisis, there is a scarcity of follow-up data. This study aims to address this gap by investigating the evolution of brain MRI markers following the management of the acute phase of malignant hypertension.Methods In this retrospective analysis, we examined brain MRI data from patients admitted for acute MHT between 2008 and 2022 at Bordeaux University Hospital. Eligible patients had at least one follow-up brain MRI available. A skilled operator conducted a comprehensive analysis of each brain MRI, searching for posterior reversible encephalopathy syndrome (PRES), acute stroke or cerebral hemorrhage and microangiopathy markers, blinded for clinical and demographical data.Results Among 149 patients enrolled, 104 had a brain MRI at inclusion, 47 individuals had at least one follow-up brain MRI and were included in the analysis. 72.3% were male, mean age was 48.2 ± 10.8 years and 46.8% presented blood pressure control at the time of the follow-up brain MRI. Median interval between initial and follow-up brain MRI was 228 (84–726) days. Five (10.6%) new recent strokes, 2 (4.3%) cerebral hemorrhage and 0 PRES were recorded during follow-up. On the follow-up brain MRI, more patients presented chronic lacunar infarct and/or microbleeds, in higher numbers. On the contrary, overall Fazekas score was stable in 31 patients (66.0%), improved in 15 patients (31.9%) and worsened in 1 patients (2.1%). Comparison of subgroups dichotomized according to blood pressure control or follow up duration showed no difference in brain MRI markers.Conclusion This study offers valuable insights into the risk of new cerebrovascular events and the evolution of brain MRI markers after managing the acute phase of malignant hypertension. Our findings emphasize the dynamic nature of cerebral microvascular burden and the potential for regression of white matter hyperintensities. A better understanding of these phenomena might contribute to improved diagnosis, tailored treatment, and proactive patient care in the context of malignant hypertension.
Deciphering the genetic battle: How Argentine Creole cattle challenge Rhipicephalus (Boophilus) microplus through their genome
Authors: Masagué María Florencia Ortega , Bonamy Martín , Cutullé Christian , Giovambattista Guillermo 
Published: June 2024

Abstract

The common cattle tick Rhipicephalus (Boophilus) microplus causes severe limitations to livestock production. Bovine genetics could be a decisive component for the success or failure of control programs for ticks and diseases transmitted. The objective of this work was to detect chromosomal regions associated with host resistance to R. (B.) microplus through an associative mapping study using medium and high density microarrays in a population of Argentine Creole cattle. The phenotypic record of the number of ticks that completed their development on the host, after artificial infestations, was obtained in 231 animals during 2015 to 2020. Genomic DNA was extracted for genotyping from 192 animals using Affymetrix high (Axiom™ Bos 1) and medium density (ArBos1) microarrays. In an exploratory study, chromosomal regions containing putative quantitative trait loci (QTLs) were recognized on chromosomes 27, 11, 10, 9, 16, 13, 3, 19, 8 and 18, associated with the variation of R. (B.) microplus load. Gene ontology based on genes located on these regions revealed an enrichment of terms and pathways for the immune system, blood coagulation, tissue regeneration, endopeptidase activity and protein phosphorylation. The information obtained in this work constitutes a first report of QTLs for tick count in the Argentine Creole cattle, and establishes the basis for additional analyzes that would contribute to the identification of biomarkers related to resistance to the common bovine tick in Argentina.
Application of Ultrasonic Shear Wave Elastography in Anal Fistula and Construction of Reference Model Values in Perianal Tissue
Authors: Tao Xiaochun , Yin Haoqiang , Hu Meng , Li Jing , Si Jichun , Liang Hongtao , Wang Chen , Cao Yongqing 
Published: June 2024

Abstract

Background
In China, ultrasound equipment is widely used, with shear wave elastography (SWE) being a popular method for assessing muscle stiffness. This study aims to establish a reference model value for perianal tissue using SWE, enhancing diagnostic capabilities for perianal conditions.
Method
Between 1st January, 2022 and 30th April, 2023, 92 patients with single-site simple anal fistula who underwent anal fistulectomy were assessed using ultrasonic SWE. Statistical methods including kernel density function, logistic regression, and ROC curve and AUC analysis were employed to establish reference values of ultrasonic SWE for perianal tissues.
Result
92 patients completed perianal normal tissue and fistula tissue detection, while 91 completed scar tissue detection. Specific critical values were identified for differentiating between perianal normal tissue and fistula tissue, with ranges varying by anatomical position. Specifically, it was 23.09 kPa (1 o'clock, 2 o'clock, 3 o'clock, 9 o'clock, 10 o'clock, and 12 o'clock positions), 38.41 kPa (5 o'clock position), 45.57 kPa (6 o'clock position), 52.99 kPa (7 o'clock position), and 41.56 kPa (11 o'clock position), respectively. The initial critical value for distinguishing scar tissue from fistula tissue was 87.28 kPa. And a range from 52.99 kPa to 87.28 kPa was deemed clinically significant for indicating fistula recurrence or residue.
Conclusion
Establishing a reference model value for perianal ultrasonic SWE enhances the diagnosis and evaluation of anal fistulae and contributes to understanding perianal tissue physiology and pathology.
Enhancing Fraud Detection: Leveraging Amazon SageMaker and Machine Learning Algorithms
Authors: Rajashekaran Karthik , Gupta Gaurav Kumar , Jain Rahul 
Published: June 2024

Abstract

Fraud detection in the financial transactions is critical challenge faced by the organizations worldwide. With advent of machine learning techniques, there has been surge in research aimed for developing robust as well as efficient fraud detection systems. This paper presents novel approach to fraud detection by using Amazon SageMaker, cloud based machine learning platform. The proposed methodology utilizes auto encoder based anomaly detection techniques in order to identify fraudulent activities in the credit card transactions. We utilize dataset comprising transactions by the European cardholders, featuring highly imbalanced class distribution with small fraction of the fraudulent instances. Through extensive experimentation along with evaluation, we demonstrate effectiveness of autoencoder model in accurately detecting the fraudulent transactions while minimizing the false positives. In addition to this, we analyzed performance of model in terms of key metrics like precision, recall, and F1-score. Our results showcased potential of Amazon SageMaker as versatile platform for developing along with deploying machine learning solutions for the fraud detection. The findings of this study contributed towards advancing field of the fraud detection along with providing valuable insights for organizations seeking towards enhancement in their security measures in terms of financial transactions.
Novel Oral Adjuvant to Enhance Cytotoxic Memory-Like NK Cell Responses in an HIV Vaccine Platform
Authors: Liyanage Namal , Alles Mario , Gunasena Manuja , Isckarus Christina , De Silva Ilmini , Board Sarah , Mulhern Will , Collins Patrick , Demberg Thorsten Demberg Thorsten 
Published: June 2024

Abstract

Antibody-dependent cell-mediated cytotoxicity, mediated by natural killer (NK) cells and antibodies, emerged as a secondary correlate of protection in the RV144 HIV vaccine clinical trial, the only vaccine thus far demonstrating some efficacy in human. Therefore, leveraging NK cells with enhanced cytotoxic effector responses may bolster vaccine induced protection against HIV. Here, we investigated the effect of orally administering indole-3-carbinol (I3C), an aryl hydrocarbon receptor (AHR) agonist, as an adjuvant to an RV144-like vaccine platform in a mouse model. We demonstrate the expansion of KLRG1-expressing NK cells induced by the vaccine together with I3C. This NK cell subset exhibited enhanced vaccine antigen-specific cytotoxic memory-like features. Our study underscores the potential of incorporating I3C as an oral adjuvant to HIV vaccine platforms to enhance antigen-specific (memory-like) cytotoxicity of NK cells against HIV-infected cells. This approach may contribute to enhancing the protective efficacy of HIV preventive vaccines against HIV acquisition.
Quantitative assessment of the governing factors of the long-term dynamics of geographically isolated wetlands: A case study within the Nenjiang River Basin, Northeast China
Authors: Ma Qiusheng , Wu Yanfeng , Zhang Guangxin , Rousseau Alain N. , Zhang Wenguang 
Published: June 2024

Abstract

Geographically isolated wetlands (GIWs) provide a portfolio of ecosystem services and contribute largely to landscape functions. Several studies have found that increasing pressure induced by climate change and anthropogenic activities on wetlands ecosystems have been significant around the world. Yet few studies have quantified the impact of natural changes and anthropogenic activities on GIWs. This paper introduces the assessment of the spatiotemporal dynamics of GIWs in the downstream portion of the Nenjiang River Basin, Northeast China. The contribution of anthropogenic activities and natural change were quantitatively evaluated for different periods over the past 38 years (1978–2015). Using a five-stage wetland dataset and four-stage land use datasets, we found that 86% of the GIWs in the study area had disappeared and mainly been replaced by unused land (28.39%) and farmland (54.90%). Anthropogenic activities were deemed responsible for this remarkable loss of wetlands from 1978 to 2008, while in recent years naturally-induced changes contributed more to the decrease of GIWs. Given the current warming and drying trends in the regional climate, efforts should be made to conserve and restore GIWs in order to foster wetland services for a multitude of beneficiaries.
The Healthcare Burden of Isolated Aortic Valve Insufficiency (AI): Analysis of a Large Health Insurance Database
Authors: Sultan Ibrahim , Ryan Michael , Gunnarsson Candace , Heidrich Natalie , Vallabhajosyula Prashanth 
Published: June 2024

Abstract

Objective
To analyze and compare the differences in mortality, healthcare utilization, and costs between patients with symptomatic and asymptomatic isolated aortic insufficiency (AI).
Methods
We utilized Optum® United Health Care database for US patients who had an AI claim between 2017 and 2022, with 12 months of continuous enrollment (baseline period) prior to diagnosis. Exclusion criteria were AVR during the baseline period or a diagnosis of aortic stenosis. Patients were split into two cohorts: those with symptoms (SAI) and those without (AAI). SAI patients had ≥ 2 visits for heart failure, angina, dyspnea, or syncope at baseline. Outcomes of interest were all-cause mortality, time to home health, time to SNF, annualized healthcare utilization, and annualized costs. We used the Cox proportional model to estimate mortality and general linear models to estimate healthcare utilization and costs. Outcomes were modeled separately.
Results
Of 249,660 patients, 58.23% were symptomatic; they were generally older and sicker than the AAI cohort, and less than 1% received AVR. Almost half of AAI patients were estimated to develop symptoms within 5 years post-diagnosis. SAI outcomes were consistently higher across all measured outcomes.
Conclusions
SAI patients have higher mortality, healthcare utilization, and costs than AAI. However, AI can progress quickly from asymptomatic to symptomatic. Early detection and timely interventions to slow the progression or address it surgically should be emphasized to limit the impact of AI.
The 18S rRNA Methyltransferase DIMT-1 Regulates Lifespan in the Germline Later in Life
Authors: Greer Eric , Rothi M. Hafiz , Alhaddad Joseph , Sarkar Gautam , Mitchell Wayne , Ying Kejun , Pohl Nancy , Sotomayor Roberto , Natale Julia , Dellacono Scarlett , Gladyshev Vadim 
Published: June 2024

Abstract

Ribosome heterogeneity has emerged as an important regulatory control feature for determining which proteins are synthesized, however, the influence of age on ribosome heterogeneity is not fully understood. Whether mRNA transcripts are selectively translated in young versus old cells and whether dysregulation of this process drives organismal aging is unknown. Here we examined the role of ribosomal RNA (rRNA) methylation in maintaining appropriate translation as organisms age. In a directed RNAi screen, we identified the 18S rRNA N6’-dimethyl adenosine (m6,2A) methyltransferase, dimt-1, as a regulator of C. elegans lifespan and stress resistance. Lifespan extension induced by dimt-1 deficiency required a functional germline and was dependent on the known regulator of protein translation, the Rag GTPase, raga-1, which links amino acid sensing to the mechanistic target of rapamycin complex (mTORC)1. Using an auxin-inducible degron tagged version of dimt-1, we demonstrate that DIMT-1 functions in the germline after mid-life to regulate lifespan. We further found that knock-down of dimt-1 leads to selective translation of transcripts important for stress resistance and lifespan regulation in the C. elegans germline in mid-life including the cytochrome P450 daf-9, which synthesizes a steroid that signals from the germline to the soma to regulate lifespan. We found that dimt-1 induced lifespan extension was dependent on the daf-9 signaling pathway. This finding reveals a new layer of proteome dysfunction, beyond protein synthesis and degradation, as an important regulator of aging. Our findings highlight a new role for ribosome heterogeneity, and specific rRNA modifications, in maintaining appropriate translation later in life to promote healthy aging.
Case Report Primary lymphoma of mucosa associated lymphoid tissue (MALT lymphoma) in the urinary bladder mimicking recurrent urinary tract infection: a case report and literature review
Authors: Liang Po-Sung , Shih Hung-Jen , Huang Sheng-Hsien , Chen Yi-Zhong 
Published: June 2024

Abstract

We report the case of a 79-year-old woman with primary lymphoma of the mucosa-associated lymphoid tissue (MALT) in the urinary bladder. The patient with urinary frequency, urgency and suprapubic pain had several emergency room visits due to recurrent urinary tract infection. Both sonogram and cystoscopy identified bladder tumors near the bladder neck. An abdominal contrast-enhanced computed tomography scan revealed a polypoid lesion on the inferior bladder wall without enlarged lymph nodes. Transurethral resection of the bladder tumor was conducted. The pathology report confirmed extranodal marginal zone MALT lymphoma. The clinical stage was IEA. Follow-up imaging reported residual bladder tumors, prompting adjuvant radiotherapy. Primary lymphoma is an uncommon pathological subtype. Its clinical and radiological differentiation from urothelial carcinoma (UC) can be challenging, but treatment strategies differ significantly. A definitive diagnosis relies on histopathology and immunohistochemistry. Typically, bladder lymphoma has a favorable prognosis, but further research is required to identify the optimal treatment.
Modeling and Mitigation Measures for Flood Inundation During the Mocha Cyclone
Authors: Singh Vikram Pratap , Sridh B. , Kuiry S.N. 
Published: June 2024

Abstract

Coastal inundation resulting from unusual sea level rise triggered by extreme weather events such as tropical cyclones or intense storms bears significant implications for coastal populations, infrastructure, and socio-economic activities. The conditions are further exacerbated when a cyclone brings heavy rainfall over the land area. To manage such disasters and foster resilient coastal communities, it's crucial to conduct comprehensive analyses of storm surges and resulting inland inundations. This study examines the combined effects of storm surge and inland flooding during a cyclone and proposes mitigation measures. Cyclone Mocha made landfall on the Myanmar coast bordering the Bay of Bengal (BoB) in 2023, resulting in significant storm surge and widespread inland flooding. This potentially impacted around 670,000 ha of land of which 327,000 ha is cropland. A detailed analysis of satellite imageries of this event revealed inundation resulting from storm surges extending over 70 km inland, a dimension often overlooked in previous research. Evaluating such events during a cyclone requires a modeling framework capable of simulating surge propagation in both ocean and inland areas. The Integrated River and Ocean Modelling System (IROMS) model is utilized for this purpose. The model outputs are validated using buoy water levels and satellite imageries of inundation extent. The results highlight the substantial risk of extensive coastal and inland flooding, evident from surge heights reaching 3.5 meters near Sittwe Port. The surge propagation patterns further illustrate the risk when water breaches onto floodplains. In addition, potential worst-case scenarios are evaluated, and mitigation measures are proposed. This study underscores the significance of proactive strategies in mitigating vulnerability and bolstering resilience in flood-prone regions of Myanmar.
Defect-assisted reversible phase transition in
mono- and few-layer ReS2
Authors: Shegai Timur , Zograf George , Yankovich Andrew , Kucukoz Betul , Agrawal Abhay , Polyakov Alexander , Ciers Joachim , Eriksson Fredrik , Haglund Åsa , Erhart Paul , Antosiewicz Tomasz , Olsson Eva 
Published: June 2024

Abstract

Transition metal dichalcogenide (TMD) materials have attracted substantial
interest due to their remarkable excitonic, optical, electrical, and mechanical
properties, which are highly dependent on their crystal structure. Controlling the
crystal structure of these materials is essential for fine-tuning their performance,
e.g., linear and nonlinear optical, as well as charge transport properties. While
various phase-switching TMD materials, like molybdenum telluride (MoTe2),
are available, their transitions are often irreversible. Here, we investigate the
mechanism of a light-induced reversible phase transition in mono- and bilayer
flakes of rhenium disulfide (ReS2). Our observations, based on scanning transmission
electron microscopy, nonlinear spectroscopy, and density functional theory
calculations, reveal a transition from the ground T′′ (double distorted T) to
the metastable H′ (distorted H) phase under femtosecond laser irradiation or
influence of highly-energetic electrons. We show that the formation of sulfur
vacancies facilitates this phenomenon. Our findings pave the way towards actively
manipulating the crystal structure of ReS2 and possibly its heterostructures.
Construction and application of copper ion and amino acid probe based on functionalized metal–organic framework probe
Authors: Liu Xinyi , Hong Dilong , Zhang Qian , Jiang Yuliang 
Published: June 2024

Abstract

The rapid development of fluorescence probe technology has promoted in-depth research in fields such as environment and life medicine. Traditional single channel fluorescent probes can achieve highly sensitive detection of targets, but they appear powerless in complex environments. In addition, in today's deteriorating resource environment, implementing multi-target detection with one probe can effectively save preparation resources, which is in line with the development direction of fluorescent probes. To achieve this goal, designing and preparing multi-site probes is undoubtedly the first choice, but its complex preparation process is daunting. Herein, a novel functional Metal Organic Framework (MOF) was obtained through post modification used UiO-66 was selected as basic skeleton. The novel MOF showed ultra sensitive detection effect on copper ions through coordination. Further, the MOF-Cu2+ can be used to detect the three types of amino acids (cysteine, homocysteine, glutathione) based on the special response between copper and sulfur. Finally, the detection application of probes for Cu2+ in the environment and amino acids in biological systems were researched respectively and achieved good results.
Characteristics in patients with very early therapeutic response of condoliase chemonucleolysis for lumbar disc herniation
Authors: Kamatani Takashi , Kitaguchi Kazuma , Kashii Masafumi 
Published: June 2024

Abstract

Introduction:
Treatment of lumbar disc herniation (LDH) using condoliase chemonucleolysis (CC) requires more time than surgery to demonstrate therapeutic effects. This study aimed to identify patients who show significant improvement in leg pain very early after CC and to determine pretreatment factors that can predict a very early therapeutic response.
Methods
The study included 52 patients who underwent CC for treatment-resistant LDH. Scores for low back and leg pain measured by a numerical rating scale were assessed at four time points (1 day, 1 week, 1 month, and 3 months after CC). Patients who reported subjective pain relief the day after treatment and further exhibited an improved straight leg raising (SLR) angle compared to pretreatment were classified as “very early responders (VER).”
Results
Of the 52 patients, 39 (75%) were VER, and 13 (25%) were non-VER. The VER showed earlier improvement in leg pain. The VER had a significantly higher proportion of positive SLR test patients (p = 0.01) and a significantly smaller pretreatment SLR angle compared to the non-VER (VER vs. non-VER: 40.6 ± 19.0 vs. 63.1 ± 16.9, p < 0.001). There were no significant differences in the level, type, and size of LDH and the disc regression rate between the two groups.
Conclusions
Patients with a smaller pretreatment SLR angle are more likely to experience very early or early symptomatic relief, with a significant and sustained reduction in leg pain up to 3 months after CC treatment.