bluuebunny/crossref_metadata_2025_split huggingface dataset:
DOES HOMO SAPIENS NEED A RECIPE FOR SURVIVAL? DO WE HAVE ONE?
Authors: Rosenberg Alexander 
Published: May 2024

AbstractIt is argued that the natural and human vicissitudes of the Northern Hemisphere—or at least western European history between 1315 and 1648—provide a preview of the sort of consequences for humanity and its demography that will result from the serious if not catastrophic climate change that is now anticipated by the Intergovernmental Panel on Climate Change (IPCC). Game theory suggests that at least some nation-state players in the strategic problem that climate change raises will not choose Nash equilibria that mitigate the problem. The only feasible solution will be the discovery or invention of some non-greenhouse-gas-emitting energy source so cheap that its owner will be indifferent to free-riding by all other users of energy. Recent efforts to develop fusion reactors do not provide much hope for this eventuality.
Unjust equal relations
Authors: Bengtson Andreas 
Published: May 2024

AbstractAccording to relational egalitarianism, justice requires equal relations. In this paper, I ask the question: can equal relations be unjust according to relational egalitarianism? I argue that while on some conceptions of relational egalitarianism, equal relations cannot be unjust, there are conceptions in which equal relations can be unjust. Surprisingly, whether equal relations can be unjust cuts across the distinction between responsibility-sensitive and non-responsibility-sensitive conceptions of relational egalitarianism. I then show what follows if one accepts a conception in which equal relations can be unjust, including why it provides a reason to grant some people less political power than others.
Anthropology and the Study of Dance: A Report
Authors: Hanna Judith Lynne 
Published: May 2024

ICAES provides an opportunity for anthropologists from throughout the world to assemble every five years. This year, a number of pre-congress conferences were organized to provide settings for intensive interaction among small groups of specialists preparatory to the general Congress sessions. The report I was asked to present to the general ICAES section drew heavily upon discussions by pre-Congress participants in dance, music, oral literature, and visual arts, as well as comments at other contemporaneous formal and informal meetings with dance anthropologists (including two active CORD members, Joann Kealiinohomoku and Anya P. Royce) and two participants from the 1972 CORD conference on Dance and Anthropology (Alan P. Merriam and Beryl Bellman). The report was, of course, also shaped by my own perspectives on the anthropological study of dance. The paragraphs which follow include what is essentially an abstract of my report to the Congress.The importance of dance as a phenomenon for anthropological study derives from its near universality, its possible biological and evolutionary significance as innate behavior with survival value (Norbeck, ICAES 1973, Blacking, ICAES 1973), its stylistic endurance, episodic nature which is in some sense repeated by other actors, malleability, apparent record in antiquity, interrelation with other behavioral phenomena, accessibility to empirical observation and film recording (Collier 1967, Sorenson 1967, Prost, ICAES 1973, Sorenson and Jablonko, ICAES 1973) and relative lack of systematic study by any of the social science disciplines (see Royce 1973 and Merriam 1973 on approaches to the study of dance). Dance as recurring human behavior thus constitutes a legitimate cultural field of inquiry.
What makes a cognate? Implications for research on bilingualism
Authors: Roembke Tanja C. , Koch Iring , Philipp Andrea M. 
Published: May 2024

Abstract
Cognates are studied in many psychological studies of bilingual language processing. Despite their frequent use, there is no clear operationalized definition of what constitutes a cognate. We conducted a literature search in three major journals to better understand how cognate status is typically defined and operationalized. In these journals, we analyzed similarity of cognate and non-cognate stimuli. We found that approximately 60% of the reviewed studies operationalized cognate status empirically. Stimulus analyses revealed a similarity continuum between cognates and non-cognates without a consistent cut-off. Based on these results, we make recommendations for future research.
Alienated Twins – The Overlooked Private Law Dimension of Global Trade and Investment Governance
Authors: Basedow J. Robert 
Published: May 2024

AbstractTwo scholarly communities work on global trade and investment governance yet communicate little with each other. On the one hand, classic trade and investment scholarship focuses on states' foreign economic policies, trade and investment treaty programs, and participation in the World Trade Organisation. On the other hand, scholars of private and commercial law study how businesses draft and enforce the international contracts of a private law nature that ultimately constitute international trade and investment transactions. This research note seeks to raise awareness for this bifurcation of research on global trade and investment, develops a conceptual framework to better understand the role of private law in shaping trade and investment flows, and proposes a research agenda anchored in economics, political economy, and political science to advance our understanding of the role of private law in global trade and investment transactions and governance.
Risk analysis of a multivariate aggregate loss model with dependence
Authors: Gao Dechen , Ren Jiandong 
Published: May 2024

AbstractThis paper studies a hierarchical risk model where an accident can cause a combination of different types of claims, whose sizes could be dependent. In addition, the frequencies of accidents that cause the different combinations of claims are dependent. We first derive formulas for computing risk measures, such as the Tail Conditional Expectation and Tail Variance of the aggregate losses for a portfolio of businesses. Then, we present formulas for performing the associated capital allocation to different types of claims in the portfolio. The main tool we used is the moment (or size-biased) transform of the multivariate distributions.
A Social‐Ecological Framework to Enhance Sustainable Reforestation Under Geological Constraints
Authors: Yue Yuemin , Wang Lu , Brandt Martin , Zhang Xinbao , Wang Kelin 
Published: May 2024

AbstractSouth China Karst faces the challenge of balancing ecological conservation and regional development, a task made more intricate by the geological limitations of carbonate formations. Large‐scale conservation and restoration initiatives have mitigated rocky desertification and positioned South China Karst as a global hotspot for vegetation regrowth over the past two decades. However, challenges stemming from geological constraints and oversights in recognizing the synergies within social‐ecological systems remain. Here, we propose a social‐ecological framework that integrates the extended timescale of both historical and recent human impacts with the corresponding processes of forest evolution. The framework elucidates the enduring and continuous progression of “forest‐deforestation‐reforestation,” offering applicability for optimizing ecological space across diverse social‐ecological contexts. Moreover, it serves to enhance the sustainability of reforestation efforts when faced with geological constraints.
Delamination Magmatism in Eastern Anatolia: A Geochemical Perspective
Authors: Aktağ Alican , Sayit Kaan , Furman Tanya , Peters Bradley J. 
Published: May 2024

AbstractThe Sr‐Nd‐Hf‐Pb isotope geochemistry of the Late Miocene Tunceli Volcanics suggests that they are the products of mixed asthenospheric and lithospheric mantle melts. The combined elemental and mineral chemistry data additionally indicate that a pyroxenite component of lithospheric origin is involved in their genesis. Calculations favor melting depths of ∼2 GPa for the Tunceli lavas, that is, deeper than the current lithosphere‐asthenosphere boundary beneath Eastern Anatolia. Geochemical data suggest that during regional Neo‐Tethyan subduction, dense (i.e., pyroxenite‐bearing) domains formed by progressive melt intrusion into the lower lithosphere resulted in gravitational instabilities. This unstable density configuration eventually led to the foundering of the eastern Anatolian lithosphere in the Late Miocene, resulting in progressive melting of fusible pyroxenite‐bearing domains at asthenospheric depths. We demonstrate that these pyroxenitic melts mixed with ambient asthenospheric melts and generated the Tunceli lavas.
Quantitative EEG features during the first day correlate to clinical outcome in perinatal asphyxia
Authors: Tuiskula Anna , Pospelov Alexey S. , Nevalainen Päivi , Montazeri Saeed , Metsäranta Marjo , Haataja Leena , Stevenson Nathan , Tokariev Anton , Vanhatalo Sampsa 
Published: May 2024

Abstract

Objective
To assess whether computational electroencephalogram (EEG) measures during the first day of life correlate to clinical outcomes in infants with perinatal asphyxia with or without hypoxic-ischemic encephalopathy (HIE).

Methods
We analyzed four-channel EEG monitoring data from 91 newborn infants after perinatal asphyxia. Altogether 42 automatically computed amplitude- and synchrony-related EEG features were extracted as 2-hourly average at very early (6 h) and early (24 h) postnatal age; they were correlated to the severity of HIE in all infants, and to four clinical outcomes available in a subcohort of 40 newborns: time to full oral feeding (nasogastric tube NGT), neonatal brain MRI, Hammersmith Infant Neurological Examination (HINE) at three months, and Griffiths Scales at two years.

Results
At 6 h, altogether 14 (33%) EEG features correlated significantly to the HIE grade ([r]= 0.39−0.61, p < 0.05), and one feature correlated to NGT ([r]= 0.50). At 24 h, altogether 13 (31%) EEG features correlated significantly to the HIE grade ([r]= 0.39−0.56), six features correlated to NGT ([r]= 0.36−0.49) and HINE ([r]= 0.39−0.61), while no features correlated to MRI or Griffiths Scales.

Conclusions
Our results show that the automatically computed measures of early cortical activity may provide outcome biomarkers for clinical and research purposes.

Impact

The early EEG background and its recovery after perinatal asphyxia reflect initial severity of encephalopathy and its clinical recovery, respectively.

Computational EEG features from the early hours of life show robust correlations to HIE grades and to early clinical outcomes.

Computational EEG features may have potential to be used as cortical activity biomarkers in early hours after perinatal asphyxia.
Accuracy, readability, and understandability of large language models for prostate cancer information to the public
Authors: Hershenhouse Jacob S. , Mokhtar Daniel , Eppler Michael B. , Rodler Severin , Storino Ramacciotti Lorenzo , Ganjavi Conner , Hom Brian , Davis Ryan J. , Tran John , Russo Giorgio Ivan , Cocci Andrea , Abreu Andre , Gill Inderbir , Desai Mihir , Cacciamani Giovanni E. 
Published: May 2024

AbstractBackgroundGenerative Pretrained Model (GPT) chatbots have gained popularity since the public release of ChatGPT. Studies have evaluated the ability of different GPT models to provide information about medical conditions. To date, no study has assessed the quality of ChatGPT outputs to prostate cancer related questions from both the physician and public perspective while optimizing outputs for patient consumption.MethodsNine prostate cancer-related questions, identified through Google Trends (Global), were categorized into diagnosis, treatment, and postoperative follow-up. These questions were processed using ChatGPT 3.5, and the responses were recorded. Subsequently, these responses were re-inputted into ChatGPT to create simplified summaries understandable at a sixth-grade level. Readability of both the original ChatGPT responses and the layperson summaries was evaluated using validated readability tools. A survey was conducted among urology providers (urologists and urologists in training) to rate the original ChatGPT responses for accuracy, completeness, and clarity using a 5-point Likert scale. Furthermore, two independent reviewers evaluated the layperson summaries on correctness trifecta: accuracy, completeness, and decision-making sufficiency. Public assessment of the simplified summaries’ clarity and understandability was carried out through Amazon Mechanical Turk (MTurk). Participants rated the clarity and demonstrated their understanding through a multiple-choice question.ResultsGPT-generated output was deemed correct by 71.7% to 94.3% of raters (36 urologists, 17 urology residents) across 9 scenarios. GPT-generated simplified layperson summaries of this output was rated as accurate in 8 of 9 (88.9%) scenarios and sufficient for a patient to make a decision in 8 of 9 (88.9%) scenarios. Mean readability of layperson summaries was higher than original GPT outputs ([original ChatGPT v. simplified ChatGPT, mean (SD),p-value] Flesch Reading Ease: 36.5(9.1) v. 70.2(11.2), <0.0001; Gunning Fog: 15.8(1.7) v. 9.5(2.0),p < 0.0001; Flesch Grade Level: 12.8(1.2) v. 7.4(1.7),p < 0.0001; Coleman Liau: 13.7(2.1) v. 8.6(2.4), 0.0002; Smog index: 11.8(1.2) v. 6.7(1.8), <0.0001; Automated Readability Index: 13.1(1.4) v. 7.5(2.1),p < 0.0001). MTurk workers (n = 514) rated the layperson summaries as correct (89.5–95.7%) and correctly understood the content (63.0–87.4%).ConclusionGPT shows promise for correct patient education for prostate cancer-related contents, but the technology is not designed for delivering patients information. Prompting the model to respond with accuracy, completeness, clarity and readability may enhance its utility when used for GPT-powered medical chatbots.
Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts
Authors: Agarwal Himanshi , Tal Perry , Goldfinger Naomi , Chattopadhyay Esita , Malkin David , Rotter Varda , Attery Ayush 
Published: May 2024

AbstractThe p53 tumor suppressor, encoded by the TP53 gene, serves as a major barrier against malignant transformation. Patients with Li-Fraumeni syndrome (LFS) inherit a mutated TP53 allele from one parent and a wild-type TP53 allele from the other. Subsequently, the wild-type allele is lost and only the mutant TP53 allele remains. This process, which is termed loss of heterozygosity (LOH), results in only mutant p53 protein expression. We used primary dermal fibroblasts from LFS patients carrying the hotspot p53 gain-of-function pathogenic variant, R248Q to study the LOH process and characterize alterations in various pathways before and after LOH. We previously described the derivation of mutant p53 reactivating peptides, designated pCAPs (p53 Conformation Activating Peptides). In this study, we tested the effect of lead peptide pCAP-250 on LOH and on its associated cellular changes. We report that treatment of LFS fibroblasts with pCAP-250 prevents the accumulation of mutant p53 protein, inhibits LOH, and alleviates its cellular consequences. Furthermore, prolonged treatment with pCAP-250 significantly reduces DNA damage and restores long-term genomic stability. pCAPs may thus be contemplated as a potential preventive treatment to prevent or delay early onset cancer in carriers of mutant p53.
Inspiration4 data access through the NASA Open Science Data Repository
Authors: Sanders Lauren M. , Grigorev Kirill A. , Scott Ryan T. , Saravia-Butler Amanda M. , Polo San-huei Lai , Gilbert Rachel , Overbey Eliah G. , Kim JangKeun , Mason Christopher E. , Costes Sylvain V. 
Published: May 2024

AbstractThe increasing accessibility of commercial and private space travel necessitates a profound understanding of its impact on human health. The NASA Open Science Data Repository (OSDR) provides transparent and FAIR access to biological studies, notably the SpaceX Inspiration4 (I4) mission, which amassed extensive data from civilian astronauts. This dataset encompasses omics and clinical assays, facilitating comprehensive research on space-induced biological responses. These data allow for multi-modal, longitudinal assessments, bridging the gap between human and model organism studies. Crucially, community-driven data standards established by NASA’s OSDR Analysis Working Groups empower artificial intelligence and machine learning to glean invaluable insights, guiding future mission planning and health risk mitigation. This article presents a concise guide to access and analyze I4 data in OSDR, including programmatic access through GLOpenAPI. This pioneering effort establishes a precedent for post-mission health monitoring programs within space agencies, propelling research in the burgeoning field of commercial space travel’s impact on human physiology.
Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method
Authors: Li Yan-Ruide , Zhou Yang , Yu Jiaji , Kim Yu Jeong , Li Miao , Lee Derek , Zhou Kuangyi , Chen Yuning , Zhu Yichen , Wang Yu-Chen , Li Zhe , Yu Yanqi , Dunn Zachary Spencer , Guo Wenbin , Cen Xinjian , Husman Tiffany , Bajpai Aarushi , Kramer Adam , Wilson Matthew , Fang Ying , Huang Jie , Li Shuo , Zhou Yonggang , Zhang Yuchong , Hahn Zoe , Zhu Enbo , Ma Feiyang , Pan Calvin , Lusis Aldons J. , Zhou Jin J. , Seet Christopher S. , Kohn Donald B. , Wang Pin , Zhou Xianghong Jasmine , Pellegrini Matteo , Puliafito Benjamin R. , Larson Sarah M. , Yang Lili 
Published: May 2024

Abstract
Cancer immunotherapy with autologous chimeric antigen receptor (CAR) T cells faces challenges in manufacturing and patient selection that could be avoided by using ‘off-the-shelf’ products, such as allogeneic CAR natural killer T (AlloCAR-NKT) cells. Previously, we reported a system for differentiating human hematopoietic stem and progenitor cells into AlloCAR-NKT cells, but the use of three-dimensional culture and xenogeneic feeders precluded its clinical application. Here we describe a clinically guided method to differentiate and expand IL-15-enhanced AlloCAR-NKT cells with high yield and purity. We generated AlloCAR-NKT cells targeting seven cancers and, in a multiple myeloma model, demonstrated their antitumor efficacy, expansion and persistence. The cells also selectively depleted immunosuppressive cells in the tumor microenviroment and antagonized tumor immune evasion via triple targeting of CAR, TCR and NK receptors. They exhibited a stable hypoimmunogenic phenotype associated with epigenetic and signaling regulation and did not induce detectable graft versus host disease or cytokine release syndrome. These properties of AlloCAR-NKT cells support their potential for clinical translation.
Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis
Authors: Bernstein Nicholas , Spencer Chapman Michael , Nyamondo Kudzai , Chen Zhenghao , Williams Nicholas , Mitchell Emily , Campbell Peter J. , Cohen Robert L. , Nangalia Jyoti 
Published: May 2024

AbstractHuman aging is marked by the emergence of a tapestry of clonal expansions in dividing tissues, particularly evident in blood as clonal hematopoiesis (CH). CH, linked to cancer risk and aging-related phenotypes, often stems from somatic mutations in a set of established genes. However, the majority of clones lack known drivers. Here we infer gene-level positive selection in whole blood exomes from 200,618 individuals in UK Biobank. We identify 17 additional genes, ZBTB33, ZNF318, ZNF234, SPRED2, SH2B3, SRCAP, SIK3, SRSF1, CHEK2, CCDC115, CCL22, BAX, YLPM1, MYD88, MTA2, MAGEC3 and IGLL5, under positive selection at a population level, and validate this selection pattern in 10,837 whole genomes from single-cell-derived hematopoietic colonies. Clones with mutations in these genes grow in frequency and size with age, comparable to classical CH drivers. They correlate with heightened risk of infection, death and hematological malignancy, highlighting the significance of these additional genes in the aging process.
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results
Authors: Sevigny Jeffrey , Uspenskaya Olga , Heckman Laura Dean , Wong Li Chin , Hatch Daniel A. , Tewari Ambika , Vandenberghe Rik , Irwin David J. , Saracino Dario , Le Ber Isabelle , Ahmed Rebekah , Rohrer Jonathan D. , Boxer Adam L. , Boland Sebastian , Sheehan Patricia , Brandes Alissa , Burstein Suzanne R. , Shykind Benjamin M. , Kamalakaran Sitharthan , Daniels Carter W. , David Litwack E. , Mahoney Erin , Velaga Jenny , McNamara Ilan , Sondergaard Patricia , Sajjad Syed A. , Kobayashi Yvonne M. , Abeliovich Asa , Hefti Franz 
Published: May 2024

AbstractGRN mutations cause progranulin haploinsufficiency, which eventually leads to frontotemporal dementia (FTD-GRN). PR006 is an investigational gene therapy delivering the granulin gene (GRN) using an adeno-associated virus serotype 9 (AAV9) vector. In non-clinical studies, PR006 transduced neurons derived from induced pluripotent stem cells of patients with FTD-GRN, resulted in progranulin expression and improvement of lipofuscin, lysosomal and neuroinflammation pathologies in Grn-knockout mice, and was well tolerated except for minimal, asymptomatic dorsal root ganglionopathy in non-human primates. We initiated a first-in-human phase 1/2 open-label trial. Here we report results of a pre-specified interim analysis triggered with the last treated patient of the low-dose cohort (n = 6) reaching the 12-month follow-up timepoint. We also include preliminary data from the mid-dose cohort (n = 7). Primary endpoints were safety, immunogenicity and change in progranulin levels in cerebrospinal fluid (CSF) and blood. Secondary endpoints were Clinical Dementia Rating (CDR) plus National Alzheimer’s Disease Coordinating Center (NACC) Frontotemporal Lobar Degeneration (FTLD) rating scale and levels of neurofilament light chain (NfL). One-time administration of PR006 into the cisterna magna was generally safe and well tolerated. All patients developed treatment-emergent anti-AAV9 antibodies in the CSF, but none developed anti-progranulin antibodies. CSF pleocytosis was the most common PR006-related adverse event. Twelve serious adverse events occurred, mostly unrelated to PR006. Deep vein thrombosis developed in three patients. There was one death (unrelated) occurring 18 months after treatment. CSF progranulin increased after PR006 treatment in all patients; blood progranulin increased in most patients but only transiently. NfL levels transiently increased after PR006 treatment, likely reflecting dorsal root ganglia toxicity. Progression rates, based on the CDR scale, were within the broad ranges reported for patients with FTD. These data provide preliminary insights into the safety and bioactivity of PR006. Longer follow-up and additional studies are needed to confirm the safety and potential efficacy of PR006. ClinicalTrials.gov identifier: NCT04408625.