bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceived need for a teacher education course on assessment literacy development: insights from EAP instructors
Authors: Estaji Masoomeh 
Published: May 2024

AbstractClassroom assessment, as a crucial element of the teaching journey, plays a significant part in enhancing student achievement, student learning, and teacher instruction. As such, teachers should possess a good grasp of assessment literacy. This study aimed to explore the EAP teachers’ perceptions regarding the demand for in-service training in various areas of language assessment, in particular, examining how a language testing and assessment (LTA) teacher education course would impact the EAP instructors’ Language Assessment Literacy (LAL). In this qualitative study, pursuing a descriptive narrative design, 60 EAP instructors were selected through purposive sampling from those who have been working in state universities in Tehran. From these participants, 30 EAP teachers were asked to write narratives regarding their needs for training on LAL, and the other 30 participants were involved in an online semi-structured interview to determine how such a course could promote or inhibit their perceptions and practices of LA and LAL. Using MAXQDA to do content and thematic analysis, the research findings revealed that EAP instructors highly perceived a need for further training especially a practice-based one. In particular, the instructors thought of teacher education courses as contributing to their theoretical and practical knowledge of LAL. Hence, teacher education courses with a specific focus on LAL are highly required, changing EAP teachers’ perspectives on LTA, from being taught solely in theory to being taught practically in real classroom environments.
GMP production of [18F]FE-PE2I on a TRACERLab FX2 N synthesis module, a radiotracer for in vivo PET imaging of the dopamine transport
Authors: Ferrat Mélodie , Moein Mohammad M. , Cananau Carmen , Tegnebratt Tetyana , Saliba Paul , Norman Fredrik , Steiger Carsten , Bratteby Klas , Samén Erik , Dahl Kenneth , Tran Thuy A. 
Published: May 2024

Abstract
Background
Parkinson's disease is a neurodegenerative disorder that is characterized by a degeneration of the dopaminergic system. Dopamine transporter (DAT) positron emission tomography (PET) imaging has emerged as a powerful and non-invasive method to quantify dopaminergic function in the living brain. The PET radioligand, [18F]FE-PE2I, a cocaine chemical derivative, has shown promising properties for in vivo PET imaging of DAT, including high affinity and selectivity for DAT, excellent brain permeability, and favorable metabolism. The aim of the current study was to scale up the production of [18F]FE-PE2I to fulfil the increasing clinical demand for this tracer.

Results
Thus, a fully automated and GMP-compliant production procedure has been developed using a commercially available radiosynthesis module GE TRACERLab FX2 N. [18F]FE-PE2I was produced with a radiochemical yield of 39 ± 8% (n = 4, relative [18F]F− delivered to the module). The synthesis time was 70 min, and the molar activity was 925.3 ± 763 GBq/µmol (250 ± 20 Ci/µmol). The produced [18F]FE-PE2I was stable over 6 h at room temperature.

Conclusion
The protocol reliably provides a sterile and pyrogen–free GMP-compliant product.
Beyond learning with cold machine: interpersonal communication skills as anthropomorphic cue of AI instructor
Authors: Zhang Shunan , Zhao Xiangying , Nan Dongyan , Kim Jang Hyun 
Published: May 2024

AbstractPrior research has explored the impact of diverse anthropomorphic interventions on the effectiveness of AI (artificial intelligence) instructors. However, the exploration of interpersonal communication skills (e.g., self-disclosure) as anthropomorphic conversational cues for AI instructors is rare. Considering the positive impact of the self-disclosure of human instructors and guided by the social penetration theory (Altman & Taylor, 1973) and computers are social actors (CASA) paradigm (Nass & Moon, 2000), this study explores the role of self-disclosure by AI instructors and the mediating role of emotional attachment between AI instructors’ self-disclosure and students’ learning experiences (learning interest and knowledge gain). Additionally, it examines the differences in students’ emotional attachment, learning interest, and knowledge gain between AI and human instructors. Through a 2 (AI instructor vs. human instructor) × 2 (self-disclosure: yes or no) experiment, this study concluded that 1) consistent with human instructors, self-disclosure by AI instructors led to higher emotional attachment, learning interest, and knowledge gain; 2) emotional attachment played an important mediating role in AI instructor self-disclosure and students’ learning interest and knowledge gain; and 3) in the context of self-disclosure, students exhibited similar levels of emotional attachment to both AI and human instructors, with no significant differences observed. Regarding learning outcomes, while students demonstrated a greater interest in learning during courses taught by AI instructors, the difference in knowledge gained from AI and human instructors was not significant. The results of this study contribute to the understanding of the anthropomorphic cues of AI instructors and provide recommendations and insights for the future use of AI instructors in educational settings.
Slips of the tongue in patients with Gilles de la Tourette syndrome
Authors: Robert Carina , Weiblen Ronja , Wagner-Altendorf Tobias A. , Paulus Theresa , Müller-Vahl Kirsten , Münchau Alexander , Krämer Ulrike M. , Heldmann Marcus , Roessner Veit , Münte Thomas F. 
Published: May 2024

Abstract
Background
Motor and vocal tics are the main symptom of Gilles de la Tourette-syndrome (GTS). A particular complex vocal tic comprises the utterance of swear words, termed coprolalia. Since taboo words are socially inappropriate, they are normally suppressed by people, which implies cognitive control processes.

Method
To investigate the control of the unintentional pronunciation of taboo words and the associated processes of conflict monitoring, we used the “Spoonerisms of Laboratory Induced Predisposition” (SLIP) paradigm. Participants read multiple inductor word pairs with the same phonemes, followed by pronouncing a target pair with inverse phonemes. This led to a conflict between two competing speech plans: the correct word pair and the word pair with inverted phonemes. Latter speech error, a spoonerism, could result in a neutral or taboo word. We investigated 19 patients with GTS and 23 typically developed controls (TDC) and measured participants’ electroencephalography (EEG) during the SLIP task.

Results
At the behavioral level less taboo than neutral word spoonerisms occurred in both groups without significant differences. Event-related brain potentials (ERP) revealed a difference between taboo and neutral word conditions in the GTS group at the midline electrodes in a time range of 250–400 ms after the speech prompt, which was not found in the TDC group. The extent of this effect depended on the number of inductor word pairs, suggesting an increasing level of cognitive control in the GTS group.

Conclusion
The differences between taboo and neutral word conditions in patients with GTS compared to TDC suggest an altered recruitment of cognitive control processes in GTS, likely enlisted to suppress taboo words.
Unicompartmental knee replacement: controversies and technical considerations
Authors: Albishi Waleed , AbuDujain Nasser M. , Aldhahri Mohammed , Alzeer Meshari 
Published: May 2024

Abstract
Background
Unicompartmental knee replacement (UKR) is one of the effective interventions for the treatment of symptomatic knee osteoarthritis. Moreover, it has multiple advantages over total knee arthroplasty (TKA), including reduced intraoperative blood loss, decreased risk of transfusion, and faster recovery. This study aimed to discuss critical technical considerations regarding UKR and some of the controversies and updates.

Methods
We conducted a review to provide an overview of the controversies and technical considerations about UKR in several aspects. Only peer-reviewed articles were included, up to December 2023 using PubMed, Google Scholar, ERIC, and Cochrane database for systematic reviews databases.

Result
UKR is associated with superior patient-reported clinical and functional outcomes, as well as shorter hospital stays, fewer postoperative complications, and revealed favorable outcomes in patients’ return to sport. The choice between mobile- and fixed-bearing prostheses depends, in part, on the surgeon’s preference. The mobile-bearing UKR is a less constrained prosthesis and can potentially result in less wear, but it is more technically demanding. While no significant difference between mobile-bearing versus fixed-bearing prostheses, cementless is superior to cemented design. Furthermore, UKR can be a good alternative for high tibial osteotomy (HTO) and still can be considered after a failed HTO. Lastly, recent reviews have shown a revision rate comparable to that of TKA. This is probably influenced by Improved comprehension of the best indications, patient selection criteria, as well as of the design, materials, and technological advances.

Conclusion
UKR treatment for unicompartmental knee osteoarthritis is secure and effective. Based on clinical and functional outcomes, decreased morbidity and mortality, and cost-effectiveness, long-term studies suggest that UKR is superior to TKA. Further investigation in this area is warranted.
Anatomo-physiological basis and applied techniques of electrical neuromodulation in chronic pain
Authors: Guzzi Giusy , Della Torre Attilio , Bruni Andrea , Lavano Angelo , Bosco Vincenzo , Garofalo Eugenio , La Torre Domenico , Longhini Federico 
Published: May 2024

AbstractChronic pain, a complex and debilitating condition, poses a significant challenge to both patients and healthcare providers worldwide. Conventional pharmacological interventions often prove inadequate in delivering satisfactory relief while carrying the risks of addiction and adverse reactions. In recent years, electric neuromodulation emerged as a promising alternative in chronic pain management. This method entails the precise administration of electrical stimulation to specific nerves or regions within the central nervous system to regulate pain signals. Through mechanisms that include the alteration of neural activity and the release of endogenous pain-relieving substances, electric neuromodulation can effectively alleviate pain and improve patients' quality of life. Several modalities of electric neuromodulation, with a different grade of invasiveness, provide tailored strategies to tackle various forms and origins of chronic pain. Through an exploration of the anatomical and physiological pathways of chronic pain, encompassing neurotransmitter involvement, this narrative review offers insights into electrical therapies’ mechanisms of action, clinical utility, and future perspectives in chronic pain management.
Pubertal Suppression in Early Puberty Followed by Testosterone Mildly Increases Final Height in Transmasculine Youth
Authors: Persky Rebecca W , Apple Danielle , Dowshen Nadia , Pine Elyse , Whitehead Jax , Barrera Ellis , Roberts Stephanie A , Carswell Jeremi , Stone Dana , Diez Sandra , Bost James , Dwivedi Pallavi , Gomez-Lobo Veronica 
Published: May 2024

Abstract

Context
Treatment for transmasculine youth (TMY) can involve testosterone treatment and is sometimes preceded by gonadotropin-releasing hormone agonist (GnRHa) treatment for puberty blockade. GnRHas can increase final height in birth-assigned females with central precocious puberty. Maximizing final adult height (FAH) is an important outcome for many TMY.

Objective
Our objective was to determine how GnRHa treatment before testosterone impacts FAH.

Methods
Retrospective cohort study at 5 US transgender health clinics. Participants were 32 TMY treated with GnRHas in early to midpuberty before testosterone (GnRHa + T group) and 62 late/postpubertal TMY treated with testosterone only (T-only group).

Results
The difference between FAH minus midparental target height (MPTH) was +2.3 ± 5.7 cm and −2.2 ± 5.6 cm in the GnRHa + T and T-only groups, respectively (P &lt; .01). In the GnRHa + T group, FAH was 1.8 ± 3.4 cm greater than predicted adult height (PAH) (P &lt; .05) and FAH vs initial height (IH) z-score was 0.5 ± 1.2 vs 0.16 ± 1.0 (P &lt; .05). After adjusting for patient characteristics, each additional month of GnRHa monotherapy increased FAH by 0.59 cm (95% CI 0.31, 0.9 cm), stage 3 breast development at start of GnRHa was associated with 6.5 cm lower FAH compared with stage 2 (95% CI −10.43, −2.55), and FAH was 7.95 cm greater in the GnRHa + T group than in T-only group (95% CI −10.85, −5.06).

Conclusion
Treatment with GnRHa in TMY in early puberty before testosterone increases FAH compared with MPTH, PAH, IH, and TMY who only received testosterone in late/postpuberty. TMY considering GnRHas should be counseled that GnRHas may mildly increase their FAH if started early.
Effects of music therapy in reducing falls among patients with dementia in a long-term facility: a cohort study
Authors: Odufuwa-Pelote Adedayo , Johnson Kelly , Jones Stacey , Carter Holly 
Published: May 2024

Background/Aims Music therapy as an intervention can reduce stress, pain, depression, isolation and anxiety without the risk of side effects associated with pharmacological interventions. Individuals with dementia are at a higher risk of falls compared to older adults with no dementia. The aim of this study was to evaluate the effect of music therapy in reducing the number of falls among patients with dementia in a long-term care facility. Methods The Morse Fall Scale was used pre-intervention and post-intervention to assess at-risk patients. Patient's attendance in music therapy and falls were tracked daily. The music sessions took place three times a week for 30 minutes. Two groups consisting of 13 patients each were included. Results There was a highly significantly higher numbers of falls reported pre-intervention (t(26)=4.108, P<0.001 at P=0.000, 95% confidence interval 0.78–2.33) compared to fall rates post-intervention (t(26)=2.842, P<0.01 at P=0.009, 95% confidence interval 0.08–0.51). A total of 80% reported no falls post-intervention compared to 62.9% reporting falls pre-intervention. Conclusions The study demonstrated that supervised music therapy is effective on fall reduction in people with dementia. Implications for practice Music sessions can be implemented in care homes for people with dementia to help reduce falls.
CLINICAL AND RADIOLOGICAL OUTCOMES OF A TAPERED FLUTED TITANIUM MONOBLOC REVISION STEM IN HIP ARTHROPLASTY AT SIX YEARS
Authors: Shaarani Shahril , Moriarty Peter , Vles Georges , Haddad Fares , Konan Sujith 
Published: May 2024

We had previously reported on early outcomes on a new fluted, titanium, monobloc stem with a three degree taper that has been designed for challenging femoral reconstruction in the setting of extensive bone loss. The aim of this study was to report its mid-term clinical and radiographic outcomes.This is a retrospective review of prospectively collected data carried out at a single institution between Jan 2017 and Dec 2019. 85 femoral revisions were performed using a new tapered, fluted, titanium, monobloc (TFTM) revision stem. Complications, clinical and radiographic data were obtained from medical records and a locally maintained database. Clinical outcomes were assessed using the Oxford Hip Score (OHS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). All post-operative radiographs were analysed for subsidence, osteolysis and femoral cortical bone remodelling.Mean follow-up was 60 months (range 28–84 months). Subsidence of 1.2 mm was noted in one patient. No cases of clinically significant subsidence (10 mm) were observed. At final follow-up, a statistically significant improvement was noted in functional outcome scores. The mean OHS preoperatively and at final follow-up were 24 (SD 13) and 42 (SD15). p = 0.04 mean difference 18 (95% CI 15–22). The mean WOMAC scores preoperatively and at final follow-up were 62 (SD23) and 88 (SD7) respectively (p < 0.001, mean difference 26; 95% CI 21–34). No stem fractures were noted within the follow-up period. Two patients had revision of the stem's one for infection and another for persistent pain.Positive mid-term clinical and radiological outcomes have been observed with this tapered, fluted, titanium, monobloc stem. Based on these results, this implant may be considered as a viable option in the majority of uncemented femoral revisions.
DOES AN INTRAOPERATIVE FEMORAL FRACTURE IMPACT ONE-YEAR PATIENT-REPORTED OUTCOME MEASURES WHEN USING A CEMENTLESS CORAIL STEM?
Authors: Robinson Mark , Wong Matthew Lynch , Cassidy Roslynn , Bryce Leeann , Lamb Jonathan , Diamond Owen , Beverland David 
Published: May 2024

The significance of periprosthetic fractures about a total hip arthroplasty (THA) is becoming increasingly important. Recent studies have demonstrated post-operative periprosthetic fracture rates are higher amongst cemented polished taper slip (PTS) stem designs compared to collared cementless (CC) designs.However, in the National Joint Registry, the rate of intra-operative periprosthetic femoral fractures (IOPFF) with cementless implant systems remains higher (0.87% vs 0.42%. p <0.001) potentially leading to more post-operative complications.This study identifies the incidence of IOPFF, the fracture subtype and compares functional outcomes and revision rates of CC femoral implants with an IOPFF to CC stems and PTS stems without a fracture.5376 consecutive CC stem THA, carried out through a posterior approach were reviewed for IOPFF. Each fracture was subdivided into calcar fracture, greater trochanter (GT) fracture or shaft fracture.1:1:1 matched analysis was carried out to compare Oxford scores at one year. Matching criteria included; sex (exact), age (± 1 year), American Society of Anaesthesiologists (ASA) grade (exact), and date of surgery (± 6 months).Electronic records were used to review revision rates.Following review of the CC stems, 44 (0.8%) were identified as having an IOPFF. Of these 30 (0.6%) were calcar fractures, 11 (0.2%) GT fractures and 3 (0.06%) were shaft fractures. There were no shaft penetrations.Overall, no significant difference in Oxford scores at one year were observed when comparing the CC IOPFF, CC non-IOPFF and PTS groups.There were no CC stems revised for any reason with either a calcar fracture or trochanteric fracture within the period of 8 years follow-up.IOPFF do occur more frequently in cementless systems than cemented. The majority are calcar and GT fractures. These fractures, when identified and managed intra-operatively, do not have worse functional outcomes or revision rates compared to matched non-IOPFF cases.
ENHANCING ELECTIVE SURGERY MANAGEMENT WITH OPENPREDICTOR: VALIDATION OF A CLINICAL DECISION AID FOR OPTIMIZING ELECTIVE PATHWAYS
Authors: Green Justin , Malviya Ajay , Reed Mike 
Published: May 2024

OpenPredictor, a machine learning-enabled clinical decision aid, has been developed to manage backlogs in elective surgeries. It aims to optimise the use of high volume, low complexity surgical pathways by accurately stratifying patient risk, thereby facilitating the allocation of patients to the most suitable surgical sites. The tool augments elective surgical pathways by providing automated secondary opinions for perioperative risk assessments, enhancing decision-making. Its primary application is in elective sites utilising lighter pre-assessment methods, identifying patients with minimal complication risks and those high-risk individuals who may benefit from early pre-assessment.The Phase 1 clinical evaluation of OpenPredictor entailed a prospective analysis of 156 patient records from elective hip and knee joint replacement surgeries. Using a polynomial logistic regression model, patients were categorised into high, moderate, and low-risk groups. This categorisation incorporated data from various sources, including patient demographics, co-morbidities, blood tests, and overall health status.In identifying patients at risk of postoperative complications, OpenPredictor demonstrated parity with consultant-led preoperative assessments. It accurately flagged 70% of patients who later experienced complications as moderate or high risk. The tool's efficiency in risk prediction was evidenced by its balanced accuracy (75.6%), sensitivity (70% with a 95% confidence interval of 62.05% to 76.91%), and a high negative predictive value (96.7%).OpenPredictor presents a scalable and consistent solution for managing elective surgery pathways, comparable in performance to secondary consultant opinions. Its integration into pre-assessment workflows assists in efficient patient categorisation, reduces late surgery cancellations, and optimises resource allocation. The Phase 1 evaluation of OpenPredictor underscores its potential for broader clinical application and highlights the need for ongoing data refinement and system integration to enhance its performance.
FROM THE TOP TO THE BOTTOM: UTILITY OF THE NOTTINGHAM HIP FRACTURE SCORE IN PREDICTING DISTAL FEMUR FRAGILITY FRACTURE MORTALITY
Authors: Vaghela Meet , Benson Daniel , Arbis Alexander , Selmon Guy , Roger Benedict , Chan Gareth 
Published: May 2024

The Nottingham Hip Fracture Score (NHFS) is validated to predict mortality after fragility neck of femur fractures (NOF). Risk stratification supports informed consent, peri-operative optimisation and case prioritisation.With the inclusion of fragility distal femur fractures (DFF) in the BPT, increasing attention is being placed on the outcome of these injuries. Developing on the lessons learnt over the past decades in NOF management is key.This study assesses the validity of the NHFS in predicting mortality after fragility DFFs.A multi-centre study of 3 high volume fragility fracture units was performed via a retrospective analysis of prospectively collected databases.Patients aged 60 years-of-age who presented with AO 33.A/B/C native DFF, or V.3.A/B periprosthetic DFF over an 86-month period between September 2014 and December 2021 and underwent surgical treatment were eligible for inclusion. Open and/or polytrauma (ISS >15) were excluded.All operations were performed or supervised by Consultant Orthopaedic Surgeons and were reviewed peri-operatively by a 7-day MDT.Patients with a NHFS of gt;=5 were stratified into a high-risk of 30-day mortality cohort, with all others being œlow-risk.285 patients were eligible for inclusion with 92 considered to be low-risk of 30-day mortality, these tended to be younger female patients admitted from their own homes.30-day mortality was 0% in the low-risk cohort and 6.2% (12/193) in the high-risk group. 1-year mortality was 8.7% (8/92) and 35.7% (69/193) in the low and high-risk groups respectively.Area Under the Curve (AUC) analyses of Receiver Operator Characteristic (ROC) curves demonstrated the greatest ability to predict mortality at 30-days for the high-risk cohort (0.714).The NHFS demonstrates a good ability to predict 30-day mortality in those patients with a NHFS =5 after a surgically managed fragility DFF. With comparable mortality outcomes to those documented from fragility NOF.