bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic analysis of Turner syndrome in Tunisian patients
Authors: Siala-Sahnoun Olfa , Laadhar Fatma , Mnif Mouna , Sefi Wajdi , Kacem Faten Hadj , Kessentini Mohamed A. , Abid Mohamed , Fakhfakh Faiza 
Published: May 2024

Background/aim
Turner syndrome (TS) is a rare sex chromosome abnormality in women, occurring in approximately one in 2500 live births, associated with a wide range of clinical stigmata of which short stature, ovarian dysgenesis, and dysmorphic features are the most frequent. Morbidity and mortality are clearly increased compared with the general population, and the average age at diagnosis is quite delayed. Even if the majority of females with TS have a non-mosaic 45,X karyotype, several karyotype variations exist, including short or long arm deletion, ring X isochromosome of the long arm, and 45,X 46,XX mosaicism. This explains the large phenotypic and genetic heterogeneities of TS, which make the diagnosis and especially the management increasingly difficult. We present in this work a genetic study of TS in the Tunisian population to establish a genotype–phenotype correlation, which would be of great help for the diagnosis and the care of patients.

Patients and methods
A total of 26 unrelated Tunisian girls were included in this study. All patients underwent a complete clinical and biochemical examination as well as karyotyping. The screening for the SRY gene was carried out by fluorescence in-situ hybridization or by PCR.

Results
Cytogenetic results showed a prevalence of the 45,X karyotype in 46% of patients and various proportions of the other karyotypes. However, genotype–phenotype correlation revealed several discrepancies regarding the major signs and the age at diagnosis. The comparison of the approaches used for the screening of the SRY gene showed that karyotyping is unable to detect low 45,X/46,XY mosaicism and that it is the PCR that would be able to do, eliciting its role to make a reliable diagnosis.

Conclusion
The karyotype alone is not sufficient to make a TS diagnosis in cases of weak mosaicism, and the great heterogeneity that reigns the syndrome elicits an epigenetic and transcriptomic exploration of several genes that recently seem to be involved in the disease.
Correlation of serum chitinase-3-like protein 1 level with cardiovascular complications in Egyptian patients with type 2 diabetes mellitus
Authors: El-Wakeel Mervat E. , Bazeed Mariam H. , Shrief Hala M. , Ghanem Ayat I. 
Published: May 2024

Background/aim
Diabetes mellitus (DM) represents a strong as well as independent risk factor toward cardiovascular diseases (CVDs), considered to be the primary reason for morbidity and mortality linked to type 2 diabetes mellitus (T2DM). DM may alter the production of many inflammatory cytokines, including chitinase-3-like protein 1 (CHI3L1). The present study aims to evaluate the correlation of serum level of CHI3L1 with cardiovascular complications in Egyptian patients with T2DM.

Participants and methods
A total of 90 participants were enrolled in this case–control study (age range 40–70 years). They were divided into three groups: Group 1, which included 30 T2DM patients with CVDs; group 2, which included 30 T2DM patients without CVDs; and group 3, which included 30 individuals as a control group. Comparison of groups in terms of demographic, laboratory, echocardiography, carotid intima-media thickness, and serum CH3L1 levels was carried out for all participants.

Results
CHI3L1 was statistically found to be highly statistically significant in group 1 over group 2 (P<0.001) and in group 2 over group 3 (P<0.001). CHI3L1 was positively correlated with the duration of DM (r=0.009; P=0.049), triglyceride (r=0.866; P=0.001), low-density lipoprotein cholesterol (r=0.950; P=0.001) and albumin/creatinine ratio (r=0.386; P=0.002), while a negative correlation existed with high-density lipoprotein cholesterol. (r=−0.408; P=0.024). On drawing an receiver operating characteristics curve between groups 1 and 2, the CHI3L1 cutoff point was less than or equal to 67.38 µg/l, and the area under the curve was 0.9193 (P=0.001) with 100% specificity and 60% sensitivity.

Conclusions
CH3L1 has better specificity and positive predictive value in the differentiation between T2DM patients with cardiovascular complications and those without cardiovascular complications, which may add a new diagnostic biomarker for early detection of CV complications, proposing new efficient therapies for such patients.
Prosthetic and biological complications of implant-retained fixed versus removable telescopic overdentures
Authors: El Naggar Shady M. , Helal Eman , Khalil Mai F.F. , Esmat El-Sisy Ahmed M. , Gouda Ayman 
Published: May 2024

Background/aim
Implant-supported prostheses proved to solve a lot of problems and difficulties associated with edentulism, yet some complications continued to appear after using the different modalities of implant-supported prostheses, so this study aimed to count and analyze the possible prosthetic and biological complications of implant-retained fixed versus removable overdentures.

Patients and methods
The study was conducted on 22 completely edentulous patients selected from the Outpatient Clinic of Prosthodontic Department, Faculty of Oral & Dental Medicine, Badr University, Egypt. They were distributed randomly into two groups: group I received implant telescopic overdentures, group II received fixed detachable screw-retained implant-supported prostheses, and prosthetic and biological complications were evaluated after 1, 3, and 6 months.

Results
The present results indicated that Χ
2 test was performed for significance evaluation between both groups in biological and prosthetic complications. In biological complications, it revealed a significant difference in relining after 6 months between both groups as P value less than 0.05. While for prosthetic complications, there was a significant difference between both groups in tooth wear and tooth separation after 6 months as P value less than 0.05.

Conclusion
Regarding prosthetic complications, telescopic overdenture showed a higher incidence than hybrid fixed screw-retained screw looseness and screw fracture. Regarding biological complications, telescopic overdenture showed the same incidence as hybrid fixed screw-retained implant looseness with a higher incidence of denture relining and lower incidence in peri-implant mucositis.
Pathological significance of fibroblast activation protein and its association with angiogenesis in colorectal carcinoma
Authors: Shabana Marwa E. , Abbas Naglaa F. , El-Sharkawy Sonia L. , Abouelfadl Dalia M. 
Published: May 2024

Background/aim
Fibroblast activation protein (FAP) as one of the complex tumor environment is expressed in activated fibroblasts and associated with poor prognosis in cancer. FAP expression in colon cancer lacks sufficient evidence to serve a significant role in angiogenesis. This study aimed to clarify the association of FAP expression with angiogenesis in the prognosis of colorectal carcinoma (CRC).

Materials and methods
A total of 50 biopsies of CRC were evaluated by immunohistochemistry for investigating FAP expression and microvascular density (MVD) using CD34 protein. In terms of FAP-positive cells and FAP staining intensity, tumors were classified as high and low expression. With respect to tumor vascularity, cases were classified into hypovascular tumors and hypervascular ones. Both of FAP expression and MVD were correlated with histological tumor grade, stage, and lymph node metastases and also with each other.

Results
FAP expression was significantly higher in malignant cases than normal nontumor tissue samples. The percentage of FAP-positive cells was significantly correlated with grade, T-stages, and lymph node metastases, while FAP intensity was significantly associated with high tumor stage only. Hypervascularity was significantly correlated with high T-stages and lymph nodes metastasis. A significant correlation was found between FAP expression percentage and MVD.

Conclusion
This study indicates that FAP is overexpressed in primary CRC and is associated with poor prognosis. The authors suggested that FAP may be used as a prognostic marker and could be reliable for predicting the angiogenic activity of CRC. Further studies are recommended applying FAP as a diagnostic marker for CRC and for evaluating its promising role as an excellent target for antitumor therapy.
Faktor Relationship Benefits yang Meningkatkan Positive Word of Mouth di Toko Buku Impor X
Authors: Witono Petrus Hepi , Fios Frederikus , Risqiani Renny 
Published: May 2024

This study aims to analyze the effect of relationship benefits on the creation of positive Word of Mouth (WOM) in imported bookstore X. In the context of increasingly competitive marketing, Word of Mouth has become a strategic focus for companies as an effective and economical alternative in influencing consumer behavior. The research method used Purposive Sampling with 200 respondents aged 18-45 years who had shopped at imported bookstore X. The majority of respondents were women (59.5%), aged 25-34 years (39.5%), and S1 graduates (56.5%). The analysis is carried out using the Structural Equation Modeling (SEM) method to examine the relationship between variables. The study involved 9 variables, including trust benefits, special treatment benefits, social benefits, information benefits, sharing benefits, functional quality, technical quality, relationship quality, and word of mouth. The results of the analysis show that Confidence Benefit and Sharing Benefit have a significant influence in increasing the sense of security and desire to share from store employees. Relationship Quality is also important to increase customer trust and satisfaction. Word of Mouth becomes a major factor in improving sales perception and reputation. This research provides a deep understanding of the role of Relationship Benefits in creating positive Word of Mouth in the retail environment, providing strategic implications for companies in designing effective WOM-based marketing programs to influence consumer preferences.
Educación ambiental en Ecozoológico San Martín cantón Baños para promover ecoturismo y conservación de especies de fauna silvestres
Authors: Cabrera Verdesoto Cesar Alberto , Espinoza Zambrano Cristian Ney , Moreno Vera Ana Noemi , Alcívar Cobeña José Luis , Bravo Paredes Diana Carolina 
Published: May 2024

The purpose of the research was to give the visitor a unique experience, in a special tour inside the facilities of the San Martín Ecozoological and certain cubiles selected by the guides, using attached tools that provide necessary information, making known the reality of the rescue centers for the care of wildlife species. In accordance with the objectives set, a tourism diagnosis of the Ecozoologico was carried out, which allowed obtaining information about the tourist facilities, physical support, supply and demand of the place, opening the way to continue with the implementation of tools for Environmental Education that raised awareness of the Ecozoologico tourists in the conservation of wildlife species, an environmental interpretation center was built and adapted to provide visual information for the visitor, also an informative script was restructured, turning it into a training manual for the guides who work at this site. Once the preparation of the program was completed, we began to make the tour a reality, randomly selecting the visitors that arrived at the Ecozoological and confirming that the program would effectively transmit environmental awareness to the tourist, The visitors participating in the Environmental Education Program were evaluated with two question tests, one at the beginning and the other at the end of the tour, to determine the level of knowledge acquired during their visit to the San Martín Ecozoological San Martín in Baños, province of Tungurahua-Ecuador.
Editorial
Authors: Lozano Zanelly Glenn Alberto 
Published: May 2024

The World Health Journal, launched in June 2020. It is an academic and scientific publication edited and fully sponsored by Professionals On Line, Peru. This publication is focused on health sciences worldwide, and publishes original articles and papers related to medical sciences, epidemiology, and public health. The thematic focus of the journal favors original and unpublished articles in the area of public health, nutrition, health policies, social security, health statistics, health education, mental health, medical ethics, epidemiological surveillance, epidemiology, administration in health, health promotion, health systems and services, and the various approaches to evidence-based medicine and medical education. The Editorial Committee values in a special way the presentation of cases, and the approach of updating topics. The purpose of the Journal is to promote and disseminate research carried out in the Health sector at an international level.
Well being in the work of a lawyer: a legal perspective
Authors: Раймбекова Ж.Е. 
Published: May 2024

Аннотация: В статье поднимается проблема well being в трудовой деятельности. В работе приведены примеры опыта зарубежных авторов по внедрению well-being программ в свою кадровую политику, которые являются собирательным элементом всех кадровых программ, используемых в организации, с подтверждением их эффективности. Внедрение в организациях подобных программ дает возможность улучшения благосостояния юристов при осуществлении ими профессиональной деятельности. По сути, благодаря благополучию на работе становится возможным пересмотреть логику и экономические соображения в свете гигиены труда. Призма благополучия на рабочем месте служит для гуманизации труда и учета при организации труда не только технических и экономических факторов, но и человеческих , которыми часто пренебрегают. Установление связи между экономикой, организацией труда и здравоохранением позволяет наладить междисциплинарный диалог. Авторами статьи сделаны выводы о непосредственном влиянии данной кадровой технологии на повышение производительности труда юристов, что благоприятно влияет на их профессиональные компетенции.
Abstract: The article raises the problem of well being in work. The paper provides examples of the experience of foreign authors on the implementation of well-being programs in their personnel policy, which are a collective element of all personnel programs used in the organization, with confirmation of their effectiveness. The introduction of such programs in organizations makes it possible to improve the welfare of lawyers in their professional activities. In fact, thanks to well-being at work, it becomes possible to revise logic and economic considerations in the light of occupational health. The prism of well-being in the workplace serves to humanize work and take into account not only technical and economic factors, but also human factors, which are often neglected, in the organization of work. The establishment of a link between the economy, labor organization and health care allows for an interdisciplinary dialogue. The authors of the article draw conclusions about the direct impact of this personnel technology on increasing the productivity of lawyers, which favorably affects their professional competencies.
Alash – the pride of the people
Authors: Ешпанов В.С. 
Published: May 2024

В статье рассмотрена Алашская идея, рожденная в начале ХХ столетия, которая продолжает служить интересам суверенного Казахстана. Раскрыто тяжелое время казахского народа ведущего борьбу за свою национальную независимость, проявляя героизм и жизнестойкость. Основной целью работы является анализ деятельности представителей национальной интеллигенции в формировании государственности. Алашская идея, рожденная в начале XX века, останется в памяти последующих поколений. В этом проявляется прямая преемственность вчерашнего и сегодняшнего дня политической истории суверенного Казахстана. С этой точки зрения можно оценивать Республику Казахстан как конкретное воплощение идеи Алаш.
The article examines the Alash idea, born at the beginning of the twentieth century, which continues to serve the interests of sovereign Kazakhstan. The difficult time of the Kazakh people fighting for their national independence, showing heroism and resilience, is revealed. The main goal of the work is to analyze the activities of representatives of the national intelligentsia in the formation of statehood. The Alash idea, born at the beginning of the 20th century, will remain in the memory of subsequent generations. This shows the direct continuity of yesterday and today in the political history of sovereign Kazakhstan. From this point of view, one can evaluate the Republic of Kazakhstan as a concrete embodiment of the Alash idea.
On problems of law enforcement (law draft support)
Authors: Канатов А.К. , Каражанов М.Д. , Қанатов А.А. 
Published: May 2024

В настоящей статье проанализированы проблемы правоохранительной сферы в аспекте законопроектного обеспечения. Авторы выделили проблемные вопросы которые требуют рассмотрения для дальнейшего совершенствования законотворческого процесса в правоохранительной сфере. Авторы привели законопроектные кейсы и пути решения данной проблемы путем консолидированного взаимодействия всех субъектов законотворческого процесса. Предлагается выработать комплексные подходы по их решению.
This article analyzes the problems of law enforcement in the aspect of legislative support. The authors identified problematic issues that require consideration for further improvement of the legislative process in the law enforcement sphere. The authors cited legislative cases and ways to solve this problem through consolidated interaction of all subjects of the legislative process. It is proposed to develop comprehensive approaches to solve them.
Grounds for setting aside court decisions based on jury verdicts
Authors: Ануфриева Е.А. 
Published: May 2024

Автором проведен анализ решений судов апелляционной и кассационной инстанций на предмет выявления типичных оснований для отмены судебных решений, постановленных на основании вердикта присяжных заседателей. В статье предлагается классификация типичных оснований отмены таких судебных решений.
The article analyzes the decisions of courts of appeal and cassation in order to identify the typical grounds for cancellation of court decisions based on the verdict of a jury. It proposes a classification system for these typical grounds.
Problems of methodological support of some forensic examinations types in Russia
Authors: Fursov V.V. 
Published: May 2024

Аннотация. В статье указывается на необходимость совершенствования и обновления методического обеспечения, разработки единого методического подхода для некоторых видов судебных экспертиз с целью исключения экспертных ошибок. Отмечено несоответствие ведомственных перечней родов и видов судебных экспертиз ввиду отсутствия единой классификации судебных экспертиз. Для совершенствования методического обеспечения судебных экспертов предлагается организовать, актуализировать и активизировать межведомственные взаимодействия, рассмотреть вопрос о внесении изменений в нормативные правовые акты России.
Annotation. The article points to the need to improve and update methodological support, to develop a unified methodological approach for some types of forensic examinations in order to exclude expert errors. The discrepancy between departmental lists of genera and types of forensic examinations was noted due to the lack of a unified classification of forensic examinations. In order to improve the methodological support of forensic experts, it is proposed to organize, update and intensify interdepartmental interactions, consider amendments to regulatory legal acts of Russia.
Authorization types that can ve used to provide access tp resources and data in mobile services
Authors: Жумадилова М.Б. , Орынбасар М.А. 
Published: May 2024

Безопасный и контролируемый доступ к ресурсам и данным в мобильных сервисах является одной из самых важных потребностей в современном мире. Постоянное развитие информационных технологий способствует их проникновению в повседневную жизнь человека, но необходимо ограничить доступ к важным и личным данным от посторонних и злоумышленников. Авторизация-это первый шаг пользователя к входу в информационную систему. В данной статье представлено сравнительное исследование наиболее распространенных и перспективных форм авторизации, а именно: доступ на основе имени и пароля, протокол OAuth, JSON Web Tokens (JWT), ключи API, биометрическая авторизация. В исследовании рассмотрен обзор ме
Мобильді қызметтердегі ресурстар мен деректерге қауіпсіз және бақыланатын түрде қол жеткізу қазіргі әлемдегі ең маңызды қажеттіліктердің бірі болып табылады. Ақпараттық технологиялардың үнемі дамуы олардың адамның күнделікті өміріне енуіне ықпал етеді, бірақ бөгде адамдар мен шабуылдаушылардан маңызды және жеке деректерге қол жеткізуді шектеу қажет. Авторизация пайдаланушының ақпараттық жүйеге кіру жолындағы алғашқы қадамы болып табылады. Бұл мақалада авторизацияның кең таралған және перспективалы түрлерін салыстырмалы зерттеу ұсынылған, атап айтқанда: есім пен парольге негізделген қол жетімділік, OAuth протоколы, JSON Web Tokens (JWT), API кілттері, биометриялық авторизация. Зерттеуде әдіске шолу, оның артықшылықтары мен кемшіліктері, сондай-ақ пайдалану шаралары мен қолдану аясы қарастырылған.
Secure and controlled access to resources and data in mobile services is one of the most important needs in the modern world. The constant development of information technologies contributes to their penetration into the daily life of a person, but it is necessary to restrict access to important and personal data from outsiders and intruders. Authorization is the first step of the user to log into the information system. This article presents a comparative study of the most common and promising forms of authorization, namely: username and password-based access, OAuth protocol, JSON Web Tokens (JWT), API keys, biometric authorization. The study provides an overview of the method, its advantages and disadvantages, as well as measures and scope of application.