bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical polarized orthogonal matrix
Authors: Tan Xiaodi , Zheng Shujun , Tan Jiaren , Xu Xianmiao , Liu Hongjie , Yang Yi , Lin Xiao 
Published: May 2024

Abstract

Orthogonal matrices have become indispensable tools in various fields, including coding, signal processing, and light field regulation. Traditionally, it has been assumed that orthogonal matrices consist of one-dimensional elements capable of modulating only amplitude or phase information. However, light waves have another critical dimension-polarization. Existing polarization orthogonal combinations have faced limitations, with a maximum pairwise orthogonal combination of 2 mapped to the basic Poincaré Sphere, hindering the regulation of polarization. Despite these challenges, we demonstrate the feasibility of constructing Optical Polarized Orthogonal Matrices (OPOMs) without restricted orthogonal numbers. This non-square matrix composed of polarization unit vectors, shows promise for multi-channel information retrieval and dynamic image display. The versatility of OPOM can be extended to various fields such as optical communication, optical storage, logic devices, anti-counterfeiting, and optical encryption.
Porcine parvovirus infection induces necroptosis of porcine placental trophoblast cells via a ZBP1-mediated pathway
Authors: Xu Ning , Du Qian , Cheng Yijiao , Nie Lichen , Ma Peipei , Feng Dingwen , Huang Yong , Tong Dewen 
Published: May 2024

Abstract

Porcine parvovirus (PPV) infection induces germ cell death, leading to reproductive disorders in first-pregnant sows. Porcine placental trophoblast cells (PTCs) are the major target of PPV, and we have previously found that PPV infection leads to the death of PTCs by a non-apoptotic process, which may be related to PPV pathogenicity. The Z-nucleic acid-binding protein 1 (ZBP1) is often activated after virus invasion and mediates subsequent cell death. Here, we found that PPV infection induced ZBP1-mediated necroptosis of porcine PTCs in the presence of the apoptosis inhibitor, AC-DEVD-CHO. ZBP1 expression was upregulated during PPV infection, and ZBP1 knockout or RNA interference significantly reduced its expression along with the PPV-induced necroptosis. We discovered that RIPK3 and MLKL, but not Caspase-8, were involved in downstream signaling of ZBP1 during PPV infection; the phosphorylation levels of RIPK3 and MLKL were enhanced, but Caspase-8 was not significantly cleaved. The knockout of RIPK3 and MLKL significantly reduced the PPV infection-induced necroptosis of porcine PTCs. RIPK3 knockout did not affect the PPV infection-induced upregulation of ZBP1 expression, but blocked the activation of MLKL. MLKL knockout did not affect the upregulation of ZBP1 expression and RIPK3 phosphorylation during PPV infection. UV-inactivated PPV induced significantly less necroptosis of porcine PTCs than non-irradiated PPV. A PPV strain with a mutation in the translation initiation codon was still able to induce necroptosis of PTCs through the ZBP1/RIPK3/MLKL pathway. These results provide new insights into the pathogenic mechanism of PPV infection and suggest that PPV infection of porcine PTCs induces necroptosis through the viral DNA-dependent ZBP1/RIPK3/MLKL pathway.
Bidirectional Mendelian randomization explores the causal relationship between arthritis and cerebral cortical volume
Authors: Xu Wantong , Ouyang Minghe , Jiang Zhongbiao 
Published: May 2024

Abstract

Background
Mendelian randomization method was used to explore the causal relationship between the occurrence of arthritis disease and volume changes in specific cerebral cortical regions.
Methods
By analyzing the GWAS summary data,SNP data related to arthritis and cerebral cortex volume were selected.Using the inverse variance weighted (IVW) method as the preferred method, MR Egger, Simple Mode, Weighted Median, and Weighted Mode were used as auxiliary analysis to conduct a two-sample bidirectional Mendelian randomization analysis.
Result
IVW analysis showed that Arthrosis was positively correlated with the volume of Left Crus I Cerebellum (OR = 1.18, 95%CI: 1.09 ~ 1.28, P = 9×10− 5).Gout was negatively correlated with the volume of Left Frontal Operculum Cortex (OR = 0.97, 95% CI: 0.95 ~ 0.98, P = 5×10− 5).Gout was positively correlated with Left Precentral Gyrus volume (OR = 1.05, 95%CI: 1.04 ~ 1.07, P = 1.9×10− 11).No positive results were obtained by reverse MR analysis.
Conclusion
Arthrosis promotes increased volume of the Left Crus I Cerebellum.Gout promotes decreased volume of the Left Frontal Operculum Cortex.Gout promotes increased volume of the Left Precentral Gyrus.
Modelling pressure dynamics of oil-gas two-phase flow in double-porosity media formation with permeability-stress sensitivity
Authors: Zhang Chunyu , Chen Shijia , Zhu Songbai , Yan Xue , Wang Hui , Wang Yanli , Li Jing-Shun , Nie Ren-Shi 
Published: May 2024

Abstract

In this research, the oil-gas two-phase flow model for a double-porosity media formation with permeability-stress sensitivity was first established for three kinds of outer boundaries. The unified governing equation was deduced by utilizing the H function. The nonlinear mathematical model in consideration of permeability-stress sensitivity was linearized by implementing the canonical perturbation transformation and then solved by using the Laplace transformation. After that, a sequence of typical log-log curves of pressure dynamics influenced by various model parameters were plotted and analyzed. These curves reflect the typical characteristic of a V shape caused by the inter-porosity fluid flow from matrix toward natural fractures. Oil saturation and permeability-stress sensitivity coefficient have much influence on the pressure dynamics. Ultimately, the established model of oil-gas two-phase flow was validated through a well-test fitting interpretation for a real condensate gas well in a sandstone formation. This research can offer insights into the pressure dynamics dominated by the oil-gas two-phase flow in naturally fractured formations and the permeability-stress sensitivity effect.
A Systematic Review of the Influence of Anorexic Voice on the Recovery of Anorexia Nervosa
Authors: Dev Athulya Thankamoney , Williams Claire 
Published: May 2024

Abstract

BACKGROUND: Anorexia nervosa (AN) caused increased mortality, and high readmissions or relapse rates indicates a lack of psychological focus on current AN intervention. Pugh and Waller (2017) thematically analyzed the high frequency of inner-voice prevalent in the AN population, similar to voice hallucinations in other psychological disorders. These remained stigmatized and non-disclosed due to correlations with Schizophrenia. The emotional and psychological AV assisting novel AN intervention is needed.
AIM: To review the relationship of AV with self and AN globally, with its influence on recovery using combined research methods.
DESIGN: Inductive thematic analysis of qualitative evidence from included studies. The methodological quality and risk of bias assessments of different studies equipped with appropriate tools.
SEARCH STRATEGY: Cochrane review, Ovid via MEDLINE, Embase, PubMed, CINAHL, Web of Science, PsychINFO, and ProQuest electronic databases searched for relevant studies selection.
REVIEW METHODS: Nine studies (one cross-sectional, one systematic review, four qualitative, and three mixed methods) met the inclusion criterion set. The methodology quality and bias risk assessments employed selective appraisal tool for included combined research methods. All appraisal tools were carefully selected and followed for robust evidence synthesis.
RESULTS: The thematic analysis concluded ‘Not one size fits all' and non-generalizable AV for different AN case. The fluctuating AV was studied subjectively since AN onset. The dissociation of AV in AN case significantly assures recovery.
CONCLUSION: This review demonstrated improved recovery with better insights in AV’s relationship with patient and AV-inclusive therapies. The need for a novel AV-inclusive psychological therapeutic framework was analysed. The improved motivation, hope, support, and empathy assures treatment success. However, AV standardized framework for unidentified AV in AN patients can possibly trigger and worsen illness.
Plasma and CSF neurofilament light chain are stabilized in response to mutant huntingtin lowering in the brain of Huntington disease mice
Authors: Caron Nicholas S. , Byrne Lauren M. , Lemarié Fanny L. , Bone Jeffrey N. , Aly Amirah E.-E. , Ko Seunghyun , Anderson Christine , Casal Lorenzo , Hill Austin M. , Hawellek David J. , McColgan Peter , Wild Edward J. , Leavitt Blair R. , Hayden Michael R 
Published: May 2024

Abstract

Background
Therapeutic approaches aimed at lowering levels of toxic mutant huntingtin (mHTT) in the brain can reverse disease phenotypes in animal models of Huntington disease (HD) and are currently being evaluated in clinical trials. Sensitive and dynamic response biomarkers are needed to assess the efficacy of such candidate therapies. Neurofilament light chain (NfL) is a biomarker of neurodegeneration that increases in cerebrospinal fluid (CSF) and blood with HD progression. However, it remains unknown whether NfL in biofluids may be useful as a response biomarker for assessing the efficacy of disease-modifying therapies for HD.
Methods
Longitudinal plasma and cross-sectional CSF samples were collected from the YAC128 transgenic mouse model of HD and wild type littermate control mice throughout the natural history of disease. Additionally, biofluids were collected from YAC128 mice following intracerebroventricular administration of an antisense oligonucleotide targeting the mutant HTT transgene (HTT ASO) at ages either before or after the onset of disease phenotypes. NfL concentrations in plasma and CSF were quantified using ultrasensitive single-molecule array technology.
Results
Plasma and CSF NfL concentrations were significantly elevated in YAC128 compared to wild type littermate control mice from 9 months of age. Treatment of YAC128 mice with either 15 or 50 µg HTT ASO resulted in dose-dependent, allele-selective reduction of mHTT throughout the brain at a 3-month interval, which was sustained with high dose HTT ASO treatment up 6 months. Lowering of mHTT in the brain with HTT ASO initiated prior to the onset of regional brain atrophy and HD-like motor deficits in YAC128 mice had minimal effect on plasma NfL at either dose but resulted in a dose-dependent reduction of CSF NfL. In contrast, initiating mHTT lowering in the brain after the onset of neuropathological and behavioural phenotypes in YAC128 mice resulted in a dose-dependent stabilization of NfL increases in both plasma and CSF.
Conclusions
Our data provides evidence that the response of NfL in biofluids is influenced by the magnitude of mHTT lowering in the brain and the timing of intervention, suggesting that NfL may represent a promising exploratory response biomarker for HD.
Coordinating Children's Palliative Care in Municipalities: A Qualitative Study
Authors: Trae Gro , Winger Anette , Nordstrøm Marianne 
Published: May 2024

Abstract

Background: Children with palliative care conditions and their families have complex care needs. In Norwegian municipalities, designated coordinators facilitate cooperation between health and social care services to ensure a holistic approach to meeting these needs. However, information is limited concerning how coordinators perform their duties and the factors influencing their work performance.
Aim: To explore the factors influencing coordinators’ motivations and work performance regarding children’s palliative care (CPC) in municipalities.
Methods: Semi-structured interviews were conducted with 11 coordinators for children in palliative care and analysed using a reflexive thematic analysis approach.
Results: Both internal and external factors influenced the coordinator's work performance, and they experienced a range of barriers in their efforts to achieve holistic care. Four themes were generated: ‘random knowledge on children’s palliative care’, ‘the abstract concept of coordination’, ‘striving to unite the fragmented whole’ and ‘aiming for tailored coordination’. A lack of training and experience in CPC is widespread among the coordinators. Additionally, the municipal systems seem inadequately developed to address the needs of children in palliative care and their families.
Conclusion: Strengthening coordination in municipalities for children in palliative care and their families requires that coordinators receive systematic training in CPC and further development of their support systems.
Deciphering the Protective Effects of Carvacrol Against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
Authors: Retnosari Rini , Ghani Muhamad Adib Abdul , Alkharji Munirah Majed , Nawi Wan Nur Izzah Shazana Wan , Rushdan Ahmad Syafi Ahmad , Mahadi Mohd Kaisan , Ugusman Azizah , Oka Natsuhisa , Zainalabidin Satirah , Latip Jalifah 
Published: May 2024

Abstract

Doxorubicin (DOX), a widely used chemotherapy, extends its impact beyond cancer cells, notably affecting the heart, leading to substantial concerns about DOX-induced cardiotoxicity (DIC). However, subclinical DIC remains unresolved, necessitating advanced cardio-protection strategies in cancer therapy. Recent research explores carvacrol (CAR), a natural substance with antioxidant and anti-inflammatory properties, as a potential shield against DIC. However, further exploration is warranted, particularly concerning hypertrophy and cardiac fibrosis. This study investigated CAR’s potential cardioprotective properties against DIC in H9c2 cardiomyocytes and rats. Induction with DOX reduced cardiomyocyte viability, while pretreatment with 0.01 µg/mL CAR enhanced the viability of DOX-induced cardiomyocytes. Meanwhile, administration of DOX induced adverse effects in rats, causing decreased total heart weight and left ventricular mass, and lowered blood pressure. DOX also caused cardiac dysfunction, lipid peroxidation, hypertrophy, and fibrosis. In rat models, CAR pretreatment effectively mitigated DOX-induced reductions in blood pressure, hypertrophy, and cardiac fibrosis. However, the pretreatment kept the heart function, oxidative stress, and antioxidant enzymes unaltered. In conclusion, the results show that CAR could be an adjuvant to reduce DIC by ameliorating cardiac fibrosis and hypertrophy.
Pharmaceutical Retail Store Performance Enhancement: The Impact of Digital Usage, 3PL Performance and Customer Orientation
Authors: GM Divakar , U Bhojanna , BM Avinash , Tantry Ansarullah 
Published: May 2024

Abstract

In the dynamic landscape of the pharmaceutical retail industry, staying competitive is important for survival and growth. Digital technologies have significantly altered consumer behavior, making incorporating technology a fundamental aspect of retail operations. In this context, the role of third-party logistics (3PL) providers becomes paramount in ensuring a seamless and efficient supply chain. This study investigated the impact of a store’s digital usage on its business performance and how the 3PL’s performance and the customer orientation of the store can change the effect. Additionally, a store inventory model was employed as a control variable to account for inventory management practices’ potential influence on the outcomes.
Using a quantitative approach, a structured survey was conducted to gather data on 568 respondents from various pharmaceutical retail stores, capturing crucial insights into their operational dynamics. The data analysis employed correlation, regression, and mediation analysis to assess the impact of digital usage on business performance within the dynamics of 3PL’s performance and customer orientation.
The results highlighted that digital integration positively influences overall business performance, indicating that adopting digital solutions enhances customer experiences and operational efficiencies. Further, customer orientation and 3PL’s performance were found to mediate the association between digital usage and store performance. Retail stores with a customer-centric focus demonstrated greater digital adoption, emphasizing the importance of aligning digital strategies with customer preferences and demands. Moreover, the store inventory management style did not modify the overall effect.
The implications of this research extended to pharmaceutical retail industry stakeholders, 3PL providers, and policymakers. The findings provided valuable insights into leveraging digital technologies for competitive advantage. The study also comprehensively explained customer orientation and 3PL performance towards the business performance. The findings contributed to the growing knowledge of supply chain management, digital transformation, and business performance in the pharmaceutical retail sector. By bridging gaps in the existing literature, the study enabled stakeholders to make informed decisions in navigating the dynamic landscape of the pharmaceutical retail industry effectively.
Calculations of the depth and dynamic frictional resistance upon drilling with a simultaneous casing based on the energy method
Authors: Pan Deyuan , Wang Jie , Fang Guoqing , Xiong Liang 
Published: May 2024

Abstract

Drilling with simultaneous casings of pneumatic DTH (down-the-hole) hammers has been extensively used in various complex formations because it can rapidly, safely and economically drill holes. The maximum depth and the skin friction associated with air DTH hammer drilling with a casing are very important parameters for project design and construction. By analyzing the conversion of impact energy and strain energy based on the energy method during the drilling process with a casing, we focused on the final stage of casing drilling and proposed a theoretical calculation method for the maximum depth and skin friction. At the same time, combined with the relevant technical specifications, the value of skin friction is improved and supplemented by analogy and induction. Finally, the theory was analyzed and validated through relevant construction examples with high accuracy, and then, the strain of the casing string under the action of a double impactor was analyzed with the concept of a neutral point. This distinguishes it from the stress wave method for calculation; its advantage is that both the strain energy and impact energy are incremental parameters at a certain time, without considering the influence of other forces during the construction process, which can greatly reduce the computational difficulty. The important calculation parameters include the casing wall thickness, casing outer diameter, and impactor power, which are exponentially related to the maximum depth and have a relatively small impact on the calculation results. The way to significantly increase the depth of drilling with a casing is to install multiple impactors on the casing string to change the force mode of the pipe string.
Causal effect of the gut microbiota and metabolites on venous thromboembolism: A Mendelian randomization analysis
Authors: Wang Xiang , Hou Xinran , Luo Hui 
Published: May 2024

Abstract

Background
The gut microbiome plays a significant role in a wide range of diseases, and its regulation is a feasible treatment option for these conditions. Emerging evidence suggests that alterations in the gut microbiota and metabolites may be associated with venous thromboembolism. However, it has yet to be definitively established whether these associations imply a causal relationship.
Methods
To explore the causal effects of the gut microbiota and metabolites on venous thromboembolism, we conducted two-sample Mendelian randomization (MR) studies using large-scale genome-wide association studies (GWASs).
Results
We identified five protective causes between the gut microbiota affected by host genetics and venous thromboembolism. These genera included LachnospiraceaeUCG10 ID:11330 (p = 0.036), RuminococcaceaeNK4A214 ID:11358 (p = 0.006), RuminococcaceaeUCG002 ID:11360 (p = 0.007), Sutterella ID:2896 (p = 0.013), and the family Erysipelotrichaceae ID:2149 (p = 0.003). Furthermore, we detected a greater abundance of gut microbiota traits in the phylum Lentisphaerae ID:2238 (p = 0.012), which is a risk factor for venous thromboembolism. We also found twelve positive and fourteen negative relationships between genetic liability in metabolites and venous thromboembolism (all p < 0.05) in terms of plasma metabolites. We did not find any evidence of pleiotropy or heterogeneity in a series of sensitivity analyses.
Conclusion
our MR analyses revealed a causal connection between the gut microbiota, metabolites, and venous thromboembolism. This finding has significant potential for shedding light on the early detection and diagnosis of venous thromboembolism, offering valuable insights into prevention and treatment in this area of research.
Engineering an Artificial Catch Bond with DNA
Authors: Li Isaac , Yang Micah , Bakker David 
Published: May 2024

Abstract

Biological catch bonds exhibit unique mechanical properties that strengthen with tension. This characteristic in selected receptor-ligand interactions underpins vital biological functions, including adhesion dynamics, cell communication, and mechanosensing. Despite decades of discoveries and modelling, an artificial catch bond has yet to be created. We present the “fish-hook”, the first rationally designed catch bond using DNA. Two mechanically distinct dissociation pathways were designed such that the weak pathway is favoured at low forces and the strong one at high forces. We developed models to design these DNA structures and experimentally validated the catch bond behaviour by single-molecule force spectroscopy. The fish-hook architecture supports a vast sequence and behaviour space, making this a valuable tool for reprogramming biological interactions and engineering novel materials.