bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse childhood experiences among people with schizophrenia at comprehensive specialized hospitals in Bahir Dar, Ethiopia: a comparative study
Authors: Assefa Fentahun Birhanu , Belete Mossie Tilahun , Damtew Hailu Rekik , Bete Tilahun , Moges Demeke Solomon 
Published: May 2024

BackgroundPeople who have encountered adverse childhood experiences (ACEs) are predisposed to developing schizophrenia, experiencing exacerbated symptoms, and facing an elevated risk of disease relapse. It is imperative to evaluate the prevalence of ACEs to comprehend the specific attributes of this condition and enable the implementation of suitable interventions.AimsThe aim of this study was to assess the prevalence of ACEs and its determinants among people with schizophrenia and the patient attendants in Bahir Dar, Ethiopia.MethodA comparative cross-sectional study was carried out at the Comprehensive Specialized Hospitals in Bahir Dar, Ethiopia, from April 26 to June 10, 2023. A total of 291 individuals with schizophrenia and 293 individuals from the patient attendants were selected using a systematic random sampling method. A proportional odds model ordinal logistic regression analysis was used to identify the factors associated with ACEs.ResultsThe occurrence of at least one ACE among individuals diagnosed with schizophrenia was 69.4%, while patient attendants had a 46.8%, as indicated by the Chi-square test, which showed a significant difference at p &lt;0.05. The study findings indicated that individuals with schizophrenia who have encountered four or more ACEs are more inclined to have lower educational attainment (AOR: 4.69 [1.94 - 11.61]), low resilient coping mechanisms (AOR: 2.07 [1.11 - 3.90]), and poor social support (AOR: 3.93 [2.13 - 7.32]). Conversely, factors such as rural residency, illiteracy, and heightened attachment-related anxiety were found to be notably associated with the patient attendants.ConclusionIn this study, the substantial prevalence of ACEs emphasized the necessity for ACE screening and the implementation of evidence-based interventions to address and alleviate the overall burden of ACEs.
Motor development-focused exercise training enhances gross motor skills more effectively than ordinary physical activity in healthy preschool children: an updated meta-analysis
Authors: Wang Xinchen , Zhou Bo 
Published: May 2024

PurposeThe growth of certain human brain structures peaks at early ages, and complex motor interventions could positively facilitate this process. This study aims to offer an updated meta-analysis regarding the effectiveness of motor development-focused exercise training on gross motor skills in preschool children.MethodsWe searched English- and Chinese-language electronic databases as of March 2024. The main eligibility criteria were as follows: participants were healthy children aged 3 to 6 years old, and the experimental design was a randomized controlled trial, with the control arm participating in either free play or ordinary physical education curriculum. We conducted a Hartung-Knapp random-effects meta-analysis of the standardized mean difference for locomotor, object control, or gross motor quotient.ResultsThe search identified 23 eligible studies, of which approximately 75% were considered to have a low risk of bias. Compared with active control, exercise training showed a large to very large effect size. Cohen’s d values were 1.13, 1.55, and 1.53 for locomotor, object control, and gross motor quotient, respectively. From a probabilistic viewpoint, these effect sizes correspond to events that are “very likely to occur” and “almost sure to occur.” Due to variations in intervention programs, all outcome measures showed high heterogeneity.ConclusionThis updated meta-analysis offers a realistic synthesis of the current evidence, leading to the conclusion that targeted motor skill exercise training can almost certainly enhance preschool children’s gross motor skills. Practical implications are discussed regarding the refinement of the instructional framework and the dissemination of these findings in preschool settings.
Genomic characterization of carbapenem and colistin-resistant Klebsiella pneumoniae isolates from humans and dogs
Authors: Pachanon Ruttana , Khine Nwai Oo , Phumthanakorn Nathita , Wongsurawat Thidathip , Niyomtham Waree , Chatsuwan Tanittha , Hampson David J. , Prapasarakul Nuvee 
Published: May 2024

IntroductionCarbapenem and colistin-resistant Enterobacteriaceae, including Klebsiella pneumoniae, have become a growing global concern, posing a significant threat to public health. Currently, there is limited information about the genetic background of carbapenem and colistin-resistant K. pneumoniae isolates infecting humans and dogs in Thailand. This study aimed to characterize carbapenem and colistin-resistant genes in six resistant K. pneumoniae clinical isolates (three from humans and three from dogs) which differed in their pulse field gel electrophoresis profiles.MethodsMatrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), antimicrobial susceptibility testing, and whole-genome sequencing were employed to identify and analyze the isolates.Results and discussionAll six isolates were carbapenemase-producing K. pneumoniae isolates with chromosomally carried blaSHV, fosA, oqxA and oqxB genes, as well as nine to 21 virulence genes. The isolates belonged to five multilocus sequence types (STs): one isolate from a human and one from a dog belonged to ST16, with the other two human isolates being from ST340 and ST1269 and the other two dog isolates were ST147 and ST15. One human isolate and two dog isolates harbored the same blaOXA-232 gene on the ColKP3 plasmid, and one dog isolate carried the blaOXA-48 gene on the IncFII plasmid. Notably, one human isolate exhibited resistance to colistin mediated by the mcr-3.5 gene carried on the IncFII plasmid, which co-existed with resistance determinants to other antibiotics, including aminoglycosides and quinolones. In conclusion, this study provides a comprehensive characterization of both chromosome- and plasmid-mediated carbapenem and colistin resistance in a set of K. pneumoniae clinical isolates from unrelated humans and dogs in Thailand. The similarities and differences found contribute to our understanding of the potential widescale dissemination of these important resistance genes among clinical isolates from humans and animals, which in turn may contribute to outbreaks of emerging resistant clones in hospital settings.
Research on the mechanism of Guanyu Zhixie Granule in intervening gastric ulcers in rats based on network pharmacology and multi-omics
Authors: Ma Ting , Ji Peng , Wu Fan-Lin , Li Chen-Chen , Dong Jia-Qi , Yang Hao-Chi , Wei Yan-Ming , Hua Yong-Li 
Published: May 2024

ObjectiveGuanyu Zhixie Granule (GYZXG) is a traditional Chinese medicine compound with definite efficacy in intervening in gastric ulcers (GUs). However, the effect mechanisms on GU are still unclear. This study aimed to explore its mechanism against GU based on amalgamated strategies.MethodsThe comprehensive chemical characterization of the active compounds of GYZXG was conducted using UHPLC-Q/TOF-MS. Based on these results, key targets and action mechanisms were predicted through network pharmacology. GU was then induced in rats using anhydrous ethanol (1 mL/200 g). The intervention effects of GYZXG on GU were evaluated by measuring the inhibition rate of GU, conducting HE staining, and assessing the levels of IL-6, TNF-α, IL-10, IL-4, Pepsin (PP), and epidermal growth factor (EGF). Real-time quantitative PCR (RT–qPCR) was used to verify the mRNA levels of key targets and pathways. Metabolomics, combined with 16S rRNA sequencing, was used to investigate and confirm the action mechanism of GYZXG on GU. The correlation analysis between differential gut microbiota and differential metabolites was conducted using the spearman method.ResultsFor the first time, the results showed that nine active ingredients and sixteen targets were confirmed to intervene in GU when using GYZXG. Compared with the model group, GYZXG was found to increase the ulcer inhibition rate in the GYZXG-M group (p &lt; 0.05), reduce the levels of IL-6, TNF-α, PP in gastric tissue, and increase the levels of IL-10, IL-4, and EGF. GYZXG could intervene in GU by regulating serum metabolites such as Glycocholic acid, Epinephrine, Ascorbic acid, and Linoleic acid, and by influencing bile secretion, the HIF-1 signaling pathway, and adipocyte catabolism. Additionally, GYZXG could intervene in GU by altering the gut microbiota diversity and modulating the relative abundance of Bacteroidetes, Bacteroides, Verrucomicrobia, Akkermansia, and Ruminococcus. The differential gut microbiota was strongly associated with serum differential metabolites. KEGG enrichment analysis indicated a significant role of the HIF-1 signaling pathway in GYZXG’s intervention on GU. The changes in metabolites within metabolic pathways and the alterations in RELA, HIF1A, and EGF mRNA levels in RT-qPCR experiments provide further confirmation of this result.ConclusionGYZXG can intervene in GU induced by anhydrous ethanol in rats by regulating gut microbiota and metabolic disorders, providing a theoretical basis for its use in GU intervention.
Australia’s states and territories Infection Prevention and Control programs – a comparison study
Authors: Dempsey Kathy , Jain Susan , Bradd Patricia , Clezy Kate , Greenfield David 
Published: May 2024

Background: Infection prevention and control (IPC) remains a critical component of delivering quality and safe care. However, clinician understanding of and engagement with IPC remain inconsistent (1–3). In addition, IPC governance, structure and organisation impact on clinician engagement are not well described. Available publications are limited to healthcare-associated infection (HAI) surveillance and do not reflect the broader IPC program (4–6). As Australia establishes a national coordinating body similar to a Centers for Disease Control and Prevention (CDC), a comparison of jurisdictional IPC provides essential contemporary information to inform the national body.
Method: This study examined the characteristics of jurisdictional (states and territories) IPC programs in Australia and was conducted in two phases. Phase one examined outward facing websites likely to be accessed by clinicians, and phase two surveyed jurisdictional programs using a qualitative questionnaire.
Results: Whilst each jurisdiction had accessible website content, this varied considerably in terms of governance, structure, content, ease of navigation, accessibility and visibility. There was a lack of national focus within jurisdictional programs and websites. Four of eight jurisdictions did not have a formal statewide IPC program at the time of the survey. Variance was reported in governance, structures, focus and program elements.
Conclusion: Inconsistent IPC governance and structure demonstrates poorly aligned Australian IPC programs that may contribute to poor clinician understanding and engagement with IPC. Implementing a coordinated and consistent approach to governance, website design and layout would facilitate a consolidated approach to IPC nationally, which may facilitate clinician understanding and engagement. Shaping IPC nationally would also provide solid IPC foundations to support an Australian CDC.
M2 Macrophage-Derived Small Extracellular Vesicles Ameliorate Pyroptosis and Intervertebral Disc Degeneration
Authors: Zhang Kaihui , Du Lilong , Li Zhenhua , Huo Zhenxin , Shen Li , Gao Shan , Jia Yiming , Zhu Meifeng , Xu Baoshan 
Published: May 2024

Intervertebral discs (IVDs) have a limited self-regenerative capacity and current strategies for IVD regeneration are unsatisfactory. Recent studies showed that small extracellular vesicles derived from M2 macrophage cells (M2-sEVs) inhibited inflammation by delivery of various bioactive molecules to recipient cells, which indicated that M2-sEVs may offer a therapeutic strategy for the repair of IVDs. Herein, we investigated the roles and mechanisms of M2-sEVs on IVD regeneration. The in vitro results demonstrated that M2-sEVs inhibited pyroptosis, preserved cellular viability, and promoted migration of nucleus pulposus cells (NPCs). Bioinformatics analysis and verification experiments of microRNA (miR) expression showed that miR-221-3p was highly expressed in M2-sEVs. The mechanism of action was explored and indicated that M2-sEVs inhibited pyroptosis of NPCs through transfer of miR-221-3p, which suppressed the expression levels of phosphatase and tensin homolog and NOD-, LRR-, and pyrin domain-containing protein 3. Moreover, we fabricated decellularized ECM-hydrogel (dECM) for sustained release of M2-sEVs, which exhibited biocompatibility and controlled release properties. The in vivo results revealed that dECM-hydrogel containing M2-sEVs (dECM/M2-sEVs) delayed the degeneration of intervertebral disc degeneration (IDD) models. In addition to demonstrating a promising therapeutic for IDD, this study provided valuable data for furthering the understanding of the roles and mechanisms of M2-sEVs in IVD regeneration.
Evaluasi dampak program keluarga berencana (KB) terhadap kemiskinan di Indonesia
Authors: Kurniawan Kurniawan - 
Published: May 2024

Pengentasan kemiskinan merupakan tujuan pertama dari Sustainable Development Goals (SDGs). Program keluarga berencana (KB) merupakan salah satu pilihan yang dilakukan pemerintah Indonesia untuk mengurangi angka kemiskinan. Keberhasilan program KB perlu dijelaskan untuk memberikan informasi yang dibutuhkan untuk mendukung program pengentasan kemiskinan. Penelitian komprehensif yang berfokus untuk menjelaskan dampak program KB terhadap pengentasan kemiskinan di Indonesia masih terbatas. Teknik analisis data oldinary least squere (OLS) menggunakan data agregat yang mencakup 34 provinsi di Indonesia pada tahun 2010-2021. Program keluarga berencana berdampak negatif terhadap kemiskinan di Indonesia. Pengendalian jumlah rumah tangga miskin keluar dari lingkaran setan kemiskinan. Ada bukti kuat yang mendorong pemerintah untuk mengevaluasi program KB menjadi prioritas investasi pemerintah dalam pengentasan kemiskinan di Indonesia.
Analisis Sistem Du Point Untuk Menilai Kinerja Keuangan Sebelum, Saat, dan Setelah Covid-19 (Studi Pada Perusahaan Saham JII dan Saham LQ45 yang Terdaftar di Bursa Efek Indonesia)
Authors: Kaujan Kaujan , Maratin Anggita Khusnul 
Published: May 2024

Penelitian ini bertujuan untuk menganalisis perbedaan Return On Equity (ROE) antara kelompok perusahaan indek saham JII dan LQ45 untuk periode sebelum, saat dan setelah pandemi Covid-19 serta menguji ada tidaknya perbedaan interaksi antara kelompokdan periode dalam mempengaruhi ROE.Â Sumber data yang digunakan merupakan data sekunder berupa laporan keuangan perusahaan khususnya neraca dan laporan laba rugi. Jenis dan pendekatan penelitian yang digunakan adalah deskriptif kuantitatif, dengan menggunakan kerangka analisis Du Pont System yang selanjutnya diuji dengan statika Univariate Repeated Measures/ANOVA. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan ROE sebelum, saat, dan setelah periode Covid-19 (p = 0.002 Î± = 0.05) baik pada kelompok indek JII maupunÂ kelompok indek LQ45. Artinya terjadi perubahan (fluktuatif) ROE baik pada kelompok indek saham JII dan indek saham JII antara sebelum, saat dan setelah Covid-19. Saat Covid-19 ROE menurun dibandingkan sebelum Covid-19 dan meningkat kembali setelah Covid-19 walaupun belum sebesar ROE sebelum Covid-19. Hal ini mencerminkan bagaimana perusahaan telah beradaptasi dan berevolusi dalam menanggapi perubahan lingkungan mereka, terutama saatÂ dan setelah melewati pandemi Covid-19. Sedangkan interaksi antara kelompok dan periode tidak berbeda dalam mempengaruhi ROE (p = 0.535 Î± = 0.05). Artinya kedua kelompok indek memiliki karakteristik yang sama dalam menghasilkan ROE baik sebelum, saat maupun setelah setelah pandemi Covid-19.
INTEGRANDO CIRURGIA E CLÍNICA MÉDICA NO TRATAMENTO DA COLELITÍASE
Authors: Pina Guilherme Cristovam , Zuza Maria Clara Alves Pinto , Silva Danillo Pedro Mendes da , Pedroso Aline Dantas Moreira , Baseman Guilherme Tambosi , Irrazabal Leandro Aparecido , Morais Joanna Cândida Costa , Garcia Ariane Simião , Silva Victor Borges da , Silva Tifany Bartolomeu  da , Souza Giovanna Alves de , Senedese Maria Silvia do Vale 
Published: May 2024

A colelitíase, caracterizada pela formação de cálculos na vesícula biliar, é uma condição comum que requer abordagens terapêuticas eficazes. O tratamento tradicional envolve a remoção cirúrgica da vesícula biliar (colecistectomia), mas cada vez mais, há uma tendência em integrar abordagens clínicas e cirúrgicas para otimizar os resultados. Esta integração visa não só tratar os sintomas agudos da colelitíase, mas também abordar as causas subjacentes e melhorar a qualidade de vida a longo prazo. Neste contexto, esta revisão explora a integração entre cirurgia e clínica médica no tratamento da colelitíase, avaliando sua eficácia, benefícios e impacto nos resultados clínicos dos pacientes. Objetivo: : Investigar a eficácia e os benefícios da integração entre cirurgia e clínica médica no tratamento da colelitíase, avaliando os resultados clínicos, a qualidade de vida dos pacientes e a redução de complicações. Metodologia: Foram utilizadas as bases de dados Cochrane, Scielo e Medline, buscando artigos publicados entre os anos de 2017 e 2024, nos idiomas Português ou Inglês. Considerações Finais: A integração entre cirurgia e clínica médica no tratamento da colelitíase representa uma abordagem promissora e eficaz. A combinação de tratamentos cirúrgicos e clínicos não só melhora os resultados clínicos, mas também reduz complicações e melhora a qualidade de vida dos pacientes. Esta abordagem integrada deve ser considerada como parte essencial do manejo da colelitíase, permitindo uma abordagem mais completa e individualizada para cada paciente.
THE INFLUENCE OF BURNOUT STUDY TOWARD STUDENTs ACHIEVEMENT
Authors: Syachrian Syahid Muh. Alief , Sahade Sahade , Rijal Abdul , Anwar Samsinar , Hasyim Sitti Hajerah 
Published: May 2024

This study aims toanalyze the effect of burnout study on the learning outcomes of students in the accounting expertise program at SMK Negeri 4 Makassar. The variables in this study are burnout studyas an independent variable and learning outcomes as a dependent variable. The population of this study is all students in the accounting expertise program at SMK Negeri 4 Makassar. The sampling technique uses theproportionate stratified random sampling technique, samples from the population are obtained from the entire population with a sample of 76 students. Data collection techniques used are questionnaires and documentation. Data analysis techniques used are percentage descriptive analysis, instrument test and hypothesis test. Based on the results of data analysis that has been carried out, the results of descriptive analysis of burnout study amounted to 44.78 percent which is classified as low and learning outcomes of 90.43 percent which are classified as very high. From the results of a simple linear regression analysis, a burnout study was obtained Ý = 84.602 + 0.094X which means that every addition of 1 burnout study value, the value of learning outcomes increased by 0.094. The results of the coefficient of determination analysis (r2) obtained the value (r2) = 0.024 which means that burnout study has a contribution to learning outcomes of 2.4 percent and the remaining 97.6 percent is influenced by other factors. While from the results of the t-test analysis obtained a significant value of 0.000<0.05 which means that burnout study has a significant positive effect on learning outcomes, thus the hypothesis is accepted. Keywords: Burnout Study, Learning Outcomes
ANALYSIS OF STUDENTS' MATHEMATICAL CRITICAL THINKING SKILLS ON STATISTICS MATERIAL IN MIDDLE SCHOOL
Authors: Dahlia Dahlia , Panjaitan Dedy Juliandri , Panjaitan Dedy Juliandri 
Published: May 2024

The purpose of the research conducted by the author was to describe the analysis of students' mathematical critical thinking skills conducted in class VIII-1 on statistics material. The type of research used in this research is qualitative research with a descriptive approach. In this study, data was collected by giving written tests of critical thinking skills and interviews. The results of this study were that subjects in the high category were able to correctly fulfill all indicators of mathematical critical thinking ability, subjects in the medium category were able to carry out 3 indicators of mathematical critical thinking ability, and subjects in the low category were only able to carry out 1 indicator. Based on the results of the analysis of data processing, the data processing of the results of student answers shows that the average acquisition of written test questions is 51.38%. The conclusion is that the mathematical critical thinking skills of class VIII-1 students of SMP Negeri 22 Medan are classified as low. Therefore, the mathematical critical thinking skills of class VIII-1 students of SMP Negeri 22 Medan still need further training so that they can be improved.Keywords: Critical Thinking Ability; StatisticsAbstrak Tujuan penelitian yang dilakukan penulis adalah untuk mendeskripsikan analisis kemampuan berpikir kritis matematis siswa yang dilakukan di kelas VIII-1 pada materi statistika. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan pendekatan deskriptif. Dalam penelitian ini data dikumpulkan melalui pemberian tes tertulis kemampuan berpikir kritis dan wawancara. Hasil penelitian ini adalah Subjek dalam kategori tinggi mampu memenuhi semua indikator kemampuan berpikir kritis matematis dengan benar, subjek dalam kategori sedang mampu melaksanakan 3 indikator kemampuan bepikir kritis matematis, dan subjek dalam kategori rendah hanya mampu melaksanakan 1 indikator saja. Berdasarkan hasil analisis pengolahan data, pengolahan data hasil jawaban siswa menunjukkan rata-rata perolehan hasil soal tes tertulis adalah 51,38%. Kesimpulannya adalah kemampuan berpikir kritis matematis siswa kelas VIII-1 SMP Negeri 22 Medan tergolong rendah. Oleh karena itu, kemampuan berpikir kritis matematis siswa kelas VIII-1 SMP Negeri 22 Medan masih perlu dilatih lebih lanjut agar dapat ditingkatkan.Kata Kunci: Kemampuan Berpikir Kritis; Statistika
Uma Experiência com Tarefas Matemáticas Abordando Paradoxos de Zenão no Ensino Médio
Authors: Pontarolo Mairon Carliel , Theodorovski Ronaldo , Trevisan André Luis , Franco Sebastião Romero 
Published: May 2024

Neste texto, relatamos uma prática de ensino no Ensino Médio, a partir do trabalho com duas tarefas matemáticas, envolvendo o tema “paradoxos”. Assumimos, que a partir deste contexto, é possível explorar intuitivamente o conceito de Progressão Geométrica e a soma dos seus infinitos termos. Contextualizamos os paradoxos no âmbito da Matemática, mais especificamente os Paradoxos de Zenão, e uma forma de incorporá-los às tarefas propostas. Relatamos, então, a experiência da aplicação da tarefa com alunos do 1º e 2º ano do Ensino Médio, concluindo que essa dinâmica envolvendo paradoxos e Progressões Geométricas fomentou o interesse, gerando debates e reflexões com profundidade, deixando indicativos de como este estudo pode contribuir para a Educação Matemática.
Keywords: Mathematics Education. Mathematical Tasks. High School. Geometric Progression. Zenon's Paradoxes.