bluuebunny/crossref_metadata_2025_split huggingface dataset:
Salmonella osteomyelitis in pregnancy
Authors: AGUSTSSON AGUST INGI , OLAFSSON KARL , THORISDOTTIR ANNA S. 
Published: August 2009

AbstractSalmonella osteomyelitis is rare in the immunocompetent host, even though Salmonella is not an infrequent public health problem. Invasive salmonellosis has in general a poor outcome in pregnancy with regard to fetal survival. We report the case of a healthy woman who developed Salmonella osteomyelitis of the iliac bone four weeks after a febrile gastroenteritis in the first trimester of pregnancy. Diagnosis was confirmed by magnetic resonance imaging scanning of the iliac bone and a growth of Salmonella enteritidis in blood culture. The patient recovered fully after six weeks treatment with intravenous antibiotics and delivered a healthy infant at 40 weeks.
Correlation of triple repeats on the FMR1 (fragile X) gene to ovarian reserve: A new infertility test?
Authors: GLEICHER NORBERT , WEGHOFER ANDREA , OKTAY KUTLUK , BARAD DAVID H. 
Published: August 2009

AbstractObjective. To determine to what degree the number of triple Cytosine/Guanine/Guanine (CGG) repeats on the FMR1 (fragile X) gene correlate with specific ovarian reserve parameters, and potentially facilitate infertility diagnosis. Design. Retrospective cohort study. Setting. Academically affiliated, private infertility center in New York City. Population. One hundred fifty‐eight consecutive women, presenting to an infertility center. Methods. Triple CGG repeat counts on the FMR1 gene were correlated with baseline follicle stimulating hormone (FSH) and anti‐Müllerian hormone (AMH), and compared to the distribution reported in the literature for general populations. Main outcome measures. Distribution of CGG counts in infertile vs. general populations and correlation between CGG counts and ovarian reserve parameters. Results. Infertile women demonstrated in both FMR1 alleles a mild shift toward higher CGG counts. In the investigated range up to 55 CGG repeats, counts inversely correlated with AMH (R2 = 0.21; p<0.001), though not with FSH, attributable to women <38 years (R2 = 0.26; p<0.001). Up to age 40, women with <35 triple repeats demonstrated higher AMH levels than those with 35–50 repeats [F (1, 87) = 5.3, p = 0.025]. Counts between 35 and 50 repeats correlated inversely to AMH (R2 = 0.41; p<0.013). Conclusions. Premature ovarian senescence and infertility in ranges up to 55 triple CGG repeats are associated with increasing triple CGG numbers on the FMR1 gene. The number of CGG repeats on the FMR1 gene appears to represent a potentially useful new test in diagnosing risk toward diminished ovarian reserve and female infertility.
Term life birth after late abortion of the first twin
Authors: WOUTERS KARLIJN A. , GIANOTTEN JUDITH , BAYRAM NERIMAN , DOORNBOS JOHANNES P.R. 
Published: August 2009

AbstractThe incidence of multiple pregnancy has increased significantly in recent years as a result of assisted reproductive therapy. The most important complication of these pregnancies remains preterm delivery. We report an extraordinary case of delayed delivery after late abortion of the first twin. Tocolysis successfully prolonged the pregnancy for more than three months, and combined with antibiotics and corticosteroids resulted in a term delivery of a second healthy sibling. A total of 37 reports that describe 145 cases of intentional delayed delivery are available. Delay of delivery may offer significant improvement in survival and outcome for the remaining fetus. Delay of delivery beyond 37 weeks is uncommon with only eight reports. A protocol for the procedure of delayed delivery of the second twin is suggested.
Low molecular weight heparin stimulates myometrial contractility and cervical remodeling in vitro
Authors: EKMAN‐ORDEBERG GUNVOR , HELLGREN MARGARETA , ÅKERUD ANNA , ANDERSSON EVA , DUBICKE AURELIJA , SENNSTRÖM MARIA , BYSTRÖM BIRGITTA , TZORTZATOS GERASIMOS , GOMEZ MARIA F. , EDLUND MÅNS , LINDAHL ULF , MALMSTRÖM ANDERS 
Published: August 2009

AbstractObjectives. The low molecular weight heparin, Dalteparin, shortens human labor time. The aim of this study was to investigate if the mechanism behind this effect involves myometrial contractility and cervical ripening and if the anticoagulative activity is necessary for its effect. Design. Experimental in vitro study. Setting. Lund University and Karolinska Institute, Sweden. Methods. The effect of low molecular weight heparins with or without anticoagulative properties on myometrial contractility was measured in vitro on smooth muscle strips from biopsies obtained at elective cesarean sections. The effects on cervical ripening were assessed in cervical fibroblasts cultured from explants of cervical biopsies obtained at delivery. Main outcome measures. Mean force and number of contractions in uterine smooth muscle strips and interleukin‐8 (IL‐8) secretion in cervical fibroblasts. Results. Myometrial smooth muscle strips pretreated with low molecular weight heparins showed increased contractile activity compared to untreated smooth muscle strips. Secretion of IL‐8 from cultured cervical fibroblasts was significantly increased after treatment with low molecular weight heparin. Both these effects were independent of anticoagulative activity of the low molecular weight heparin. Conclusions. A possible underlying mechanism for the shortened labor time after low molecular weight heparin treatment is enhanced myometrial contractility and an increased IL‐8 secretion in cervical fibroblast, mimicking the final cervical ripening in vivo. Our data support the notion that anticoagulant activity is not required to promote labor.
Endometriosis‐associated nerve fibers and pain
Authors: MEDINA MELISSA G. , LEBOVIC DAN I. 
Published: August 2009

AbstractThe assessment and diagnosis of endometriosis remain elusive targets. Patient and medical‐related factors add to delays in the detection and treatment. Recently, investigators have revealed specific nerve fibers present in endometriotic tissue, with existing parallels between density and pain severity. The aim of this review is to compile a comprehensive review of existing literature on endometriosis‐related nerve fiber detection, and the effects of medical therapy on these neural fibers. We performed a systematic literature‐based review using Medline and PubMed of nerve fibers detected in eutopic endometrium, endometriotic lesions, and the peritoneum. Various arrangements of significant medical terms and phrases consisting of endometriosis, pelvic pain, nerve fiber detection/density in endometriosis, and diagnoses methodology, including treatment and detection were applied in the search. Subsequent references used were cross‐matched with existing sources to compile all additional similar reports. Similar nerve fibers were detected within lesions, endometrium, and myometrium, though at varying degrees of density. Hormonal therapy is widely used to treat endometriosis and was shown to be related to a reduction in fiber density. A direct result of specific nerve fiber detection within eutopic endometrial layers points to the use of a minimally invasive endometrial biopsy technique in reducing delay in diagnosis and subsequent possible preservation of fertility.
Telephone Case Management Reduces Both Distress and Psychiatric Hospitalization
Authors: Andrews Gavin , Sunderland Matthew 
Published: August 2009

Objective: The aim of the present study was to improve the health care of people repeatedly admitted to private hospitals. Method: An open trial in which frequent utilizers were offered telephone case management over a 12 month period, was conducted. Results: An average of 24 phone calls were made to the 99 who remained in the programme for the 12 months. Psychological distress declined significantly over the 12 months, and the number of days in hospital was reduced compared to the previous year. The cost benefit ratio was 1:8.4. Conclusions: The changes in well-being and hospitalization over the 12 months were substantial and are unlikely to be due to regression to the mean. A prospective randomized controlled trial comparing telephone case management with treatment as usual is indicated.
Randomized Controlled Trial of Interventions for Young People at Ultra-High Risk of Psychosis: Study Design and Baseline Characteristics
Authors: Phillips Lisa J. , Nelson Barnaby , Yuen Hok Pan , Francey Shona M. , Simmons Magenta , Stanford Carrie , Ross Margaret , Kelly Daniel , Baker Kathryn , Conus Philippe , Amminger Paul , Trumpler Francois , Yun Yang , Lim Michelle , McNab Catharine , Yung Alison R. , McGorry Patrick D. 
Published: August 2009

Objective: Intervention during the pre-psychotic period of illness holds the potential of delaying or even preventing the onset of a full-threshold disorder, or at least of reducing the impact of such a disorder if it does develop. The first step in realizing this aim was achieved more than 10 years ago with the development and validation of criteria for the identification of young people at ultra-high risk (UHR) of psychosis. Results of three clinical trials have been published that provide mixed support for the effectiveness of psychological and pharmacological interventions in preventing the onset of psychotic disorder. Method: The present paper describes a fourth study that has now been undertaken in which young people who met UHR criteria were randomized to one of three treatment groups: cognitive therapy plus risperidone (CogTher + Risp: n = 43); cognitive therapy plus placebo (CogTher + Placebo: n = 44); and supportive counselling + placebo (Supp + Placebo; n = 28). A fourth group of young people who did not agree to randomization were also followed up (monitoring: n = 78). Baseline characteristics of participants are provided. Results and conclusion: The present study improves on the previous studies because treatment was provided for 12 months and the independent contributions of psychological and pharmacological treatments in preventing transition to psychosis in the UHR cohort and on levels of psychopathology and functioning can be directly compared. Issues associated with recruitment and randomization are discussed.
Evaluation of factors relating to tumor recurrence and survival after resection of lung cancer
Authors: Kim Eun Soo , Lee In Jae , Bae Young-A , Lee Jae-Woong , Im Hyoung June , Jeon Yong Hwan 
Published: August 2009

Background: Most patients whose lung cancers are resected have a local or distant recurrence, as determined postoperatively, or show residual or local disease at the time of autopsy. There are few reports that have described a relationship between tumor recurrence and variable factors such as stage, pathology, surgical method, and mode of recurrence. Purpose: To determine factors associated with tumor recurrence after resection of lung cancer. Material and Methods: A total of 124 patients who underwent surgical resection of lung cancer also underwent follow-up with computed tomography (CT) imaging (6, 12, and 24 months after surgery) for the surveillance of tumor recurrence. The CT images were retrospectively reviewed, focusing on the hilar or mediastinal lymph nodes, surgical margin, lung parenchyma, pleura, chest wall, and the presence of distant metastasis. The rate, mode, and time to recurrence after surgery were compared with the tumor stage, pathology, and operative method to identify factors associated with tumor recurrence. The correlation between survival and tumor stage was also evaluated. Results: For 112 cases, a tumor recurred in 52 (41.0%) cases. The recurrence rate was lower for patients with stage IA ( n=5, 9.6%) as compared to patients with stage IB ( n=18, 34.6%), stage II ( n=11, 21.1%), or stage IIIA ( n=18, 34.6%). The differences in the recurrence rate between patients with stage IA and stage IB, stage IA and stage II, and stage IA and stage IIIA were statistically significant ( P<0.05). The mode of recurrence in the 52 cases was local recurrence ( n=31, 59.6%), distant metastasis ( n=17, 32.7%), and combined lesions ( n=4, 7.7%). The variations in survival rate were statistically significant between patients with stage IA and stage IB ( P<0.05) and between patients with stage IA and stage IIIA ( P<0.01). Other factors such as pathology and operative method did not correlate with tumor recurrence or patient survival. Conclusion: The tumor stage was the only factor associated with tumor recurrence and survival after resection of lung cancer.
Effect of clinical experience of chest tomosynthesis on detection of pulmonary nodules
Authors: Zachrisson S. , Vikgren J. , Svalkvist A. , Johnsson Å. A. , Boijsen M. , Flinck A. , Månsson L. G. , Kheddache S. , Båth M. 
Published: August 2009

Background: The new technique chest tomosynthesis refers to the principle of collecting low-dose projections of the chest at different angles and using these projections to reconstruct section images of the chest at a radiation dose comparable to that of chest radiography. Purpose: To investigate if, for experienced thoracic radiologists, the detectability of pulmonary nodules obtained after only a short initial learning period of chest tomosynthesis improves with additional clinical experience of the new technique. Material and Methods: Two readings of the same clinical chest tomosynthesis cases, the first performed after 6 months of clinical experience and the second after an additional period of 1 year, were conducted. Three senior thoracic radiologists, with more than 20 years of experience of chest radiography, acted as observers, with the task of detecting pulmonary nodules in a jackknife free-response receiver operating characteristics (JAFROC1) study. The image material consisted of 42 patients with and 47 patients without pulmonary nodules examined with chest tomosynthesis. Multidetector computed tomography (MDCT) was used as a reference. The total number of nodules was 131. The JAFROC1 figure of merit (FOM) was used as the principal measure of detectability. Results: The difference in the observer-averaged JAFROC1 FOM of the two readings was 0.004 (95% confidence interval: -0.11, 0.12; F-statistic: 0.01 on 1 and 2.65 df; P=0.91). Thus, no significant improvement in detectability was found after the additional clinical experience of tomosynthesis. Conclusion: The study indicates that experienced thoracic radiologists already within the first months of clinical use of chest tomosynthesis are able to take advantage of the new technique in the task of detecting pulmonary nodules.
PerM: efficient mapping of short sequencing reads with periodic full sensitive spaced seeds
Authors: Chen Yangho , Souaiaia Tade , Chen Ting 
Published: August 2009

Abstract
Motivation: The explosion of next-generation sequencing data has spawned the design of new algorithms and software tools to provide efficient mapping for different read lengths and sequencing technologies. In particular, ABI's sequencer (SOLiD system) poses a big computational challenge with its capacity to produce very large amounts of data, and its unique strategy of encoding sequence data into color signals.
Results: We present the mapping software, named PerM (Periodic Seed Mapping) that uses periodic spaced seeds to significantly improve mapping efficiency for large reference genomes when compared with state-of-the-art programs. The data structure in PerM requires only 4.5 bytes per base to index the human genome, allowing entire genomes to be loaded to memory, while multiple processors simultaneously map reads to the reference. Weight maximized periodic seeds offer full sensitivity for up to three mismatches and high sensitivity for four and five mismatches while minimizing the number random hits per query, significantly speeding up the running time. Such sensitivity makes PerM a valuable mapping tool for SOLiD and Solexa reads.
Availability: http://code.google.com/p/perm/
Contact: tingchen@usc.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Average seasonal changes in chlorophyll a in Icelandic waters
Authors: Guðmundsson Kristinn , Heath Mike R. , Clarke Elizabeth D. 
Published: August 2009

Abstract
Guðmundsson, K., Heath, M. R., and Clarke, E. D. 2009. Average seasonal changes in chlorophyll a in Icelandic waters. – ICES Journal of Marine Science, 66: 2133–2140. The standard algorithms used to derive sea surface chlorophyll a concentration from remotely sensed ocean colour data are based almost entirely on the measurements of surface water samples collected in open sea (case 1) waters which cover ∼60% of the worlds oceans, where strong correlations between reflectance and chlorophyll concentration have been found. However, satellite chlorophyll data for waters outside the defined case 1 areas, but derived using standard calibrations, are frequently used without reference to local in situ measurements and despite well-known factors likely to lead to inaccuracy. In Icelandic waters, multiannual averages of 8-d composites of SeaWiFS chlorophyll concentration accounted for just 20% of the variance in a multiannual dataset of in situ chlorophyll a measurements. Nevertheless, applying penalized regression spline methodology to model the spatial and temporal patterns of in situ measurements, using satellite chlorophyll as one of the predictor variables, improved the correlation considerably. Day number, representing seasonal variation, accounted for substantial deviation between SeaWiFS and in situ estimates of surface chlorophyll. The final model, using bottom depth and bearing to the sampling location as well as the two variables mentioned above, explained 49% of the variance in the fitting dataset.
Growth of European hake (Merluccius merluccius) in the Gulf of Lions based on conventional tagging
Authors: Mellon-Duval Capucine , de Pontual Hélène , Métral Luisa , Quemener Loic 
Published: August 2009

Abstract
Mellon-Duval, C., de Pontual, H., Métral, L., and Quemener, L. 2010. Growth of European hake (Merluccius merluccius) in the Gulf of Lions based on conventional tagging. – ICES Journal of Marine Science, 67: 62–70. Growth of European hake was estimated from the results of a conventional tagging study in the Gulf of Lions, the first tagging experiment to have been undertaken on the species in Mediterranean waters. In all, 4277 hake 15–40 cm long were tagged and released on the inshore fishing grounds during spring 2006. The overall recapture rate was 6.5% and times-at-liberty ranged from 1 to 717 d. Growth rate in hake varied with size and sex. The estimated growth parameter (von Bertalanffy k) was estimated as double previously published values based on size frequency distribution in the area. Compared with recent growth parameters derived from the tagging experiments in the Bay of Biscay, k was estimated to be slightly lower in the Gulf of Lions. With this faster growth, hake would mature earlier than previously thought: at age 2 for both sexes, instead of at age 3 or 4 as currently accepted for the Mediterranean. Growth rate by sex decreased to a similar level once fish had attained sexual maturity.
Estimating ocean wave directional spreading from an Eulerian surface elevation time history
Authors: Adcock T. A. A. , Taylor P. H. 
Published: August 2009

The directional spreading of sea states is an important design parameter in offshore engineering. Wave directionality affects the resulting wave kinematics, which affects the forces exerted on offshore structures. In this paper, we develop a method for estimating the amount of spreading, when the only information available is the time history of free surface elevation at a single point in space.
We do this by predicting the second-order bound waves that occur at the difference in frequency of two freely propagating waves. The magnitude of these second-order bound waves is a function of the angle between the interacting waves. Thus, it is possible to infer some information about spreading from a single-point time history.
We demonstrate that this approach works for wave groups in a fully nonlinear numerical wave tank. We create a synthetic random sea state and introduce noise into the analysis and thus show that our approach is robust and insensitive to noise, even with a signal-to-noise ratio of unity in the difference waves. This approach is also applied to random waves in a physical wave tank where spreading was directly measured and also to a storm recorded in the North Sea. In all cases, we find our estimate of spreading is in good agreement with other measurements.
Unraveling the Evolution of Cytokinin Signaling
Authors: Pils Birgit , Heyl Alexander 
Published: August 2009

AbstractThe conquest of the land by plants required dramatic morphological and metabolic adaptations. Complex developmental programs under tight regulation evolved during this process. Key regulators of plant development are phytohormones, such as cytokinins. Cytokinins are adenine derivatives that affect various processes in plants. The cytokinin signal transduction system, which is mediated via a multistep variant of the bacterial two-component signaling system, is well characterized in the model plant Arabidopsis (Arabidopsis thaliana). To understand the origin and evolutionary pattern of this signaling pathway, we surveyed the genomes of several sequenced key plant species ranging from unicellular algae, moss, and lycophytes, to higher land plants, including Arabidopsis and rice (Oryza sativa), for proteins involved in cytokinin signal transduction. Phylogenetic analysis revealed that the hormone-binding receptor and a class of negative regulators first appeared in land plants. Other components of the signaling pathway were present in all species investigated. Furthermore, we found that the receptors evolved under different evolutionary constraints from the other components of the pathway: The number of receptors remained fairly constant, while the other protein families expanded.
In Folio Respiratory Fluxomics Revealed by 13C Isotopic Labeling and H/D Isotope Effects Highlight the Noncyclic Nature of the Tricarboxylic Acid “Cycle” in Illuminated Leaves
Authors: Tcherkez Guillaume , Mahé Aline , Gauthier Paul , Mauve Caroline , Gout Elizabeth , Bligny Richard , Cornic Gabriel , Hodges Michael 
Published: August 2009

Abstract
While the possible importance of the tricarboxylic acid (TCA) cycle reactions for leaf photosynthesis operation has been recognized, many uncertainties remain on whether TCA cycle biochemistry is similar in the light compared with the dark. It is widely accepted that leaf day respiration and the metabolic commitment to TCA decarboxylation are down-regulated in illuminated leaves. However, the metabolic basis (i.e. the limiting steps involved in such a down-regulation) is not well known. Here, we investigated the in vivo metabolic fluxes of individual reactions of the TCA cycle by developing two isotopic methods, 13C tracing and fluxomics and the use of H/D isotope effects, with Xanthium strumarium leaves. We provide evidence that the TCA “cycle” does not work in the forward direction like a proper cycle but, rather, operates in both the reverse and forward directions to produce fumarate and glutamate, respectively. Such a functional division of the cycle plausibly reflects the compromise between two contrasted forces: (1) the feedback inhibition by NADH and ATP on TCA enzymes in the light, and (2) the need to provide pH-buffering organic acids and carbon skeletons for nitrate absorption and assimilation.