bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances in the prerequisite and consequence of STING downstream signalosomes
Authors: Lu Xinliang , Li Xiaobing , Li Lili , Han Chuanhui , Li Sirui 
Published: May 2024

Abstract
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an evolving DNA-sensing mechanism involved in innate immunity and pathogen defense that has been optimized while remaining conserved. Aside from recognizing pathogens through conserved motifs, these receptors also detect aberrant or misplaced self-molecules as possible signs of perturbed homeostasis. Upon binding external or self-derived DNA, a mobile secondary messenger 2′3′-cyclic GMP-AMP (cGAMP) is produced by cGAS and in turn activates its adapter STING in the endoplasmic reticulum (ER). Resting-state or activated STING protein is finely restricted by multiple degradation machineries. The post-translational changes of the STING protein, along with the regulatory machinery of the secret routes, limit the onset, strength and sustention of STING signal. STING experiences a conformational shift and relocates with TBK1 from the ER to perinuclear vesicles containing transcription factors, provoking the transcription activity of IRF3/IFN-I and NF-κB pathways, as well as to initiate a number of cellular processes that have been shown to alter the immune landscape in cancer, such as autophagy, NLRP3 inflammasome, ER stress, and cell death. STING signal thus serves as a potent activator for immune mobilization yet also triggers immune-mediated pathology in tissues. Recent advances have established the vital role of STING in immune surveillance as well as tumorigenic process. This review provides an overview of the disparate outcomes of cancer attributed to the actions of pleiotropic and coordinated STING downstream signalosomes, along with the underlying mechanisms of STING function in pathologies, providing therapeutic implications for new approaches in hunt for the next generation of cancer immunotherapy base on STING.
Comment on “Fast and accurate electromagnetic field calculation for substrate-supported metasurfaces using the discrete dipole approximation”
Authors: Chaumet Patrick C. 
Published: May 2024

Abstract
The article entitled “Fast and accurate electromagnetic field calculation for substrate-supported metasurfaces using the discrete dipole approximation (DDA)” written by W. Liu and E. McLeod presents a method for computing the Green function in presence of a substrate or multilayer in an efficient way. Unfortunately, the proposed method has been known for more than twenty years and significantly ameliorated. It can be found in its optimized version in some open-source DDA codes. In this comment, we recall the different approaches (and related papers) addressing the computation of the Green function of a multilayered system. We show that they address all the points raised by Liu and McLeod in their paper and provide more efficient solutions to their computational issues.
The preterite of Spanishandar: An “unbiased” history of non-standard vs. standard forms
Authors: Rini Joel 
Published: May 2024

AbstractAlongside the standard irregular preterite of Sp.andar(anduve‘I walked’) there exist non-standard regular forms (andé‘I walked’). Scholars have assumed that the non-standard regular forms have resulted from analogy with the preterite of regular-arverbs, agree that the irregular preterite ofandarwas formed by analogy with the etymological irregular preterite ofestar, and have assumed that the earliest forms were the irregular ones. But if the preterite ofandarwas formed by analogy with that ofestar, what were the etymological forms of the preterite ofandarinherited from Latin? This question has not been raised hitherto because of “standard language bias”, a phenomenon recently introduced by Maiden (2022). It will be revealed here that non-standard forms inand-appear by the early thirteenth century. Their early appearance, together with comparative Romance evidence, points to the likelihood that they were not formed by later processes of analogy and regularization, but that they were, and are, direct descendants of one of a number of possible Latin etyma. Finally, it will be explained why forms inanduv-eclipsed the original forms inand-, eventually becoming the standard, as well as why they have persisted as such to date.
Integración y asociatividad territorial colombiana: perspectiva comparada desde el contexto internacional
Authors: López Marín July Alejandra , Rodriguez Bonilla Clarivel 
Published: May 2024

El artículo presenta un recorrido sobre la asociatividad territorial colombiana desde una perspectiva comparada con América Latina y otros contextos del continente europeo. El objetivo es identificar formas asociativas territoriales en diferentes entornos internacionales con el fin de contrastarlas con la implementación que se ha tenido de esta estrategia en Colombia. El análisis se soportó en una revisión documental y normativa de los tres contextos para profundizar en posibles razones que expliquen las deficiencias que se encuentran en el modelo colombiano. Se concluye que la asociatividad territorial es un instrumento con alto potencial para la gestión del desarrollo, no obstante, se hace necesario precisar su alcance y redefinir fuentes de financiación e incentivos.* * Este artículo se elaboró en el marco del proyecto de investigación Una visión de la asociatividad territorial y sus efectos en las capacidades del municipio, esquemas: RAP Eje Cafetero, Área Metropolitana Centro Occidente y Asocentro Sur de Caldas, el cual fue avalado por la Facultad de Investigaciones de la Escuela Superior de Administración Pública (ESAP).
Spaces for contemporary education in engineering: É81 and G56
Authors: Greg András , Medvegy Gabriella , Veres Gábor , Bachmann Bálint , Kokas Balázs , Paári Péter 
Published: May 2024

AbstractThe article represents a case study of the realization of changing engineering education in two new contemporary educational buildings of the University of Pécs, the impact of these buildings on educational methods, and the impact of community-based education on these buildings. As part of the university development program launched in 2016, the University of Pécs, Faculty of Engineering and Information Technology's campus has been expanded with new architectural education buildings. The task of the new buildings was to adapt to the directions of the new engineering education and the representation of education of its faculty. The engineering education influences the object of architecture and determines its operation and its layout.
Experimental investigation of RTS method to calculate heat gain on walls and flat roof
Authors: Hassan Khalil Khalil , Danışmaz Merdin , Al-Bayati Omer Adil Zainal 
Published: May 2024

AbstractMulti-layered walls are commonly used building elements that have the potential to reduce cooling loads by improving thermal insulation. This paper investigates the potential of reducing cooling load using different types of multi-layered. For this purpose, a model of a small room (1.15 × 1 × 1 m) was constructed. A software code based on the radiant time series method was developed using MATLAB to extract heat gain results. The results were verified with other researchers, and there was a 0.89% error. Overall, the results show that using solid or hollow bricks in construction can be an effective way to reduce heat gain, where Wall-C achieved the minimum heat gain of 60.8 W m−2 compared to 66.207 and 71.225 W m−2 for Wall-A and Wall-B respectively. The reasons for this could be due to the insulation hollow area provided by the bricks, which tends to reduce heat transfer through the wall.
Serendipity in psychotropic drugs: Unearthing the origins
Authors: Imran Mehreen , Semira  
Published: May 2024

This is a dive into the history of several groundbreaking psychiatric drugs and their discoveries. The article begins by exploring the curious origin of the word “serendipity” following Horace Walpole’s encounter with a fairytale. This captivating emergence of “serendipity” is followed by an account of lithium discovered in 1817. About a century and a half later, lithium would receive FDA approval, becoming a cornerstone in the treatment of mania.The narrative meanders to other drugs that have a similar thread of serendipity woven into their beginnings— chlordiazepoxide, meprobamate, chlorpromazine, finally halting at iproniazid, an anti-tubercular agent that unexpectedly revealed its mood-enhancing potential and paved the way for the development of monoamine oxidase inhibitors as antidepressants.The authors navigate through the intricacies of chance and discovery that have influenced the trajectory of psychiatric drug development, leading to unexpected breakthroughs that have forever left their mark on the undeniably vast landscape that is mental health.
The Problem of Understanding the Integrity and Ontological Differentiation of Technology
Authors: Rosin V.M. 
Published: May 2024

The article poses two questions. First, how should we think about the integrity of technology, given that it consists of very different entities (phenomena)? What, for example, do tools, technical structures, mechanisms, machines, the technical environment, and technology have in common? The answer that all these phenomena are artifacts created by man, who spied and enhanced the effects of nature, is clearly insufficient. Secondly, what relationships connect the listed types of technology? To answer, the author analyzes several cases (the formation of the ancient Egyptian pyramids, the prerequisites of the first industrial revolution, the formation of engineering, technology, A. Bogdanov’s theory “Tektology”), using the methodology of cultural and historical reconstruction developed by him, which in turn relies on the means of a number of humanitarian and social sciences. Sci. He shows that the implementation of this methodology makes it possible to characterize not only the patterns of formation of different types and essences of technology, but also to describe their unique features (singular aspect), as well as to understand the relationships they have.
Geopolitics as a Dangerous Pathology of Political Consciousness
Authors: Obolonsky A.V. 
Published: May 2024

The article is analytical and does not connected with questions of current politics. The radical difference between politics in genuine, Aristotelian meaning od word and political manipulations for solution of current political issues od day is emphasized. The historical, moral and sociological aspects of geopolitical paradigm in terms of imminent defectiveness of it and caused multiple negative consequences are considered. Among the topics of analysis are historical origin and evolution of geopolitical ideology from ancient China till European version of it – Machiavellianiism, and also a modern definition and understanding of geopolitics. The imminent pathologies of geopolitical consciousness are connected with mythology on national exclusiveness, ostensible uniqueness of different countries’ “special path”, etc. It was burdened in addition in several European states by post imperial political syndrome. Special sections of article are devoted to key crossroads in the history of Russia and also to condition of public political consciousness in the post Soviet period. It is characterized by deformations of value system, complex of social inferiority, fear of changes and deep socio psychological trauma. That usual for transit periods and finds a sort of compensation in vulgar pseudo patriotism. On the other side, the author is disagree and argues against of pessimistic, fatalistic judgements of Russian national political consciousness and culture and against of conclusion on supposed unpreparedness of us to democratic development.
évaluation aux Archives cantonales vaudoises
Authors: Visconti Simone 
Published: May 2024

À travers l’analyse de l’évaluation aux Archives cantonales vaudoises, cet article questionne le lien entre production théorique et pratique. L’évaluation des ACV est d’abord replacée dans un contexte archivistique plus large, théorique, normatif et méthodologique. Des éléments problématiques sont questionnés, tels que la répartition des rôles dans l’évaluation entre archivistes (valeur historique) et représentants de l’administration (valeur juridico-administrative). La deuxième partie de l’article se concentre sur la pratique de l’évaluation aux ACV et souligne un manque de « transparence » malgré les efforts consentis pour rendre le processus décisionnel moins aléatoire. L’article se termine avec la présentation d’outils de travail destinés à améliorer la visibilité et la réflexivité de l’évaluation.
Da autoria literária
Authors: Granja Lúcia 
Published: May 2024

O dossiê “Da autoria literária”, que chega agora ao seu segundo volume, é uma ação do grupo de pesquisa CNPq “Da autoria literária: história atualidade e perspectivas”, o qual tem, desde 2021, o objetivo de aprofundar a reflexão sobre a autoria literária no Brasil, desde o século XIX até a contemporaneidade. Como propusemos na chamada de trabalhos, a noção de “autoria/autoria literária” foi definida por meio de debates acerca de (novos) conceitos estéticos, jurídicos, bem como de novas práticas literárias, editoriais e institucionais ao longo do século XVIII. A “autoria” modificou-se também por meio dos paradigmas da modernidade, do surgimento de novas mídias e suportes, da crise em torno da representação, de novas ideias estéticas. As respostas à proposta de dossiê criada para a revista Remate de Males foram vastas e variadas, de modo que a publicação prevista se multiplicou e deu origem a dois volumes, um no primeiro semestre de 2023 e outro, no segundo.
Development of future elementary school teachers' professional self-education readiness through interactive teaching methods
Authors: Kenesbekova Saltanat , Mukhametzhanova Aigul , Kussainova Marzhangul , Zhanbyrbayeva Sayan , Alipbayeva Laura 
Published: May 2024

A modern specialist's ability to self-educate is a valuable professional quality. Education has been given the essential responsibility to develop the learners' readiness for self-education (RSE). However, university students experience difficulties organizing and implementing self-educational activities. The study's goal is to investigate the development of students' RSE and the impact of interactive training methods (ITMs) on ensuring the development of self-education skills in future elementary school (FES) teachers. The study used a pre- and post-test design for FES teachers' readiness for self-education (RSE). The study involved 240 learners at E. Buketov Karaganda University, Karaganda, Kazakhstan. The study found that university students experienced difficulties in organizing and implementing self-educational activities. The findings revealed that using integrative teaching methods increased students' readiness for self-education which is a significant improvement over traditional methods. This paper contributes to the methodological potential of university education by providing an innovative approach to improve university students' self-education preparation.
Global Inquiry Reveals PBL's Impact on Junior High Ecoliteracy
Authors: Amelia Dita , Wulandari Fitria Eka 
Published: May 2024

This study investigates the impact of Problem-Based Learning (PBL) on the ecoliteracy abilities of grade VII junior high school students compared to conventional lecture-based instruction. Conducted at SMP Muhammadiyah 6 Krian, the quasi-experimental research involved 40 students divided into experimental and control groups. Pre-test and post-test assessments using ecoliteracy indicators were conducted. Results from T-tests showed no significant difference in ecoliteracy abilities between the two groups (experimental group: p = 0.090, control group: p = 0.270), suggesting that PBL did not significantly improve ecoliteracy skills among grade VII students. These findings underscore the need for further exploration of instructional methods to enhance ecoliteracy in junior high school settings. Highlight: PBL's Effect on Ecoliteracy: Assessing PBL's impact on junior high ecoliteracy. Quasi-Experimental Design: Non-equivalent control group method in research design. Call for Further Research: Identifying effective environmental education strategies. Keyword: Problem-Based Learning, Ecoliteracy, Junior High School, Quasi-Experimental Research, Environmental Education
Berbagi Foto Digital: Motif, Faktor Kepribadian, dan Komunikasi Termediasi
Authors: Hidayanto Syahrul , Zahra Fina 
Published: May 2024

Media sosial saat ini menjadi platform berbagi foto digital yang diminati mayoritas pengguna internet di dunia. Tujuan diciptakannya media sosial adalah mulai dari sarana komunikasi hingga menjadi wadah untuk berbagi foto. Di media sosial, berbagi foto digital dianggap lebih efektif dalam mengekspresikan diri pengguna dibanding berbagi status lewat teks. Daya tangkap audiens media sosial lebih cepat ketika informasi disampaikan melalui foto digital. Penelitian ini bertujuan untuk memahami bagaimana motivasi pengguna membagikan foto digitalnya di media sosial dan faktor kepribadian yang melatar belakanginya. Berdasarkan kajian literatur, masih jarang dijumpai penelitian yang menghubungkan motivasi berbagi foto digital dengan kepribadian pengguna media sosial. Total empat informan terpilih setelah melalui proses pencarian dan seleksi berdasarkan kriteria. Penelitian ini menggunakan tiga metode pengumpulan data yaitu obeservasi tidak langsung, wawancara semi terstruktur, dan studi literatur. Data penelitian yang sudah terkumpul kemudian diberikan kode dengan tiga tahapan pengkodean yaitu open, axial, dan selective coding. Data hasil pengkodean selanjutnya dianalisis menggunakan analisis tematik. Berdasarkan hasil penelitian, motivasi memori, ekspresi diri, dan pemeliharaan hubungan adalah tiga motivasi teratas seseorang berbagi foto digitalnya di media sosial. Temuan lainnya adalah seseorang yang melakukan aktivitas berbagi foto digital biasanya memiliki karakteristik kepribadian extraversion, openness to experience, dan agreeableness dengan derajat yang cukup tinggi.
Decoding the Digital Revolution Critical Success Factors for Digitization in The Oil and Gas Industry
Authors: Ziadat Wael , Kirkham Richard 
Published: May 2024

Abstract
The dawn of the digital era has brought about a paradigm shift across various industrial sectors, with the Oil and Gas industry being no exception. The rapid progression of technology offers transformative potential to this traditionally capital-intensive industry. This paper delves into the heart of this digital revolution, exploring the critical success factors that drive the successful digitization of the Oil and Gas industry. Advanced technologies like Artificial Intelligence, Big Data, the Internet of Things (IoT), and Blockchain are currently reshaping this industry's contours. We will mainly focus on leveraging these technologies to improve operational efficiency, enhance safety measures, reduce environmental impact, and ultimately drive profitability in the Oil and Gas sector.
However, the journey towards comprehensive digitization is fraught with challenges. From data security issues to the need for significant investments and workforce upskilling, there are numerous hurdles that need to be addressed. Hence, we will also shed light on these potential roadblocks and propose viable strategies to overcome them.
This paper aims to provide a roadmap for navigating the digitization journey effectively and efficiently by decoding the digital revolution in the Oil and Gas industry. Through an in-depth analysis of the critical success factors for digitization, we hope to offer valuable insights that can fuel the industry's transition towards a more sustainable and profitable future.
Optimizing Surfactant Additives and Nanosheet to Increase Oil Recovery in High Temperature and High Salinity Reservoirs
Authors: Cao D. , Alotaibi M. , Huang T. , Fahmi M. 
Published: May 2024

Abstract
Amphiphilic molybdenum disulfide (AMD) nanosheet is a novel flake type nanomaterial with unique behaviors on oil/water interfaces compared with particulate nanomaterials for increasing oil production. Surfactant additives are the key enabler for the nanosheet injection to solve the compatibility problem in high temperature and high salinity reservoirs. This study optimized some surfactant additives for the nanosheet to demonstrate some synergism effects at target reservoir conditions. Nanosheet/surfactant candidates with similar interfacial tension (IFT) performance but different emulsification abilities were compared.
Original AMD nanosheet solution was a concentrated black liquid with the flake size about 80*60*1.2 nanometer (nm). The performances in a high salinity water (HSW) and high temperature up to 95°C were characterized by compatibility test, IFT measurement, and emulsification evaluation. The dynamic adsorption and oil production potential in porous media were evaluated by coreflooding tests. Indiana limestones with similar permeability were used. Performances of the nanosheet with different surfactant additives were evaluated.
The AMD nanosheet was not compatible with HSW at 95°C. Two surfactants, named as S1 and S2, out of 20 samples showed significant compatibility improvements to nanosheet solution at a very low dosage concentration. IFTs of two nanosheet/surfactant mixtures with a light oil were both at magnitude of 10-2 mN/m, which were much lower than the values of nanosheet alone and surfactant alone. However, the emulsification abilities of the two nanosheet/surfactant systems with crude oil were quite different. S1 surfactant improved the emulsification ability of nanosheet, while S2 surfactant weakened the emulsion stability compared with nanosheet alone case. Accordingly, nanosheet/surfactant S1 injection produced a long-lasted emulsified oil and nanosheet/surfactant S2 injection formed a large oil bank at early stage in the oil displacement tests. But the ultimate oil recoveries of the two systems were almost the same.
This study provides some insights of interaction between AMD nanosheet and surfactants and its effect on oil production performance. Improved nanosheet systems were developed to increase oil production under harsh conditions.