bluuebunny/crossref_metadata_2025_split huggingface dataset:
Negotiating pace, focus and identities: Patient/public involvement/engagement in a palliative care study
Authors: Forbat Liz , Macgregor Aisha , Brown Talitha , McCormack Brendan , Spilsbury Karen , Rutherford Alasdair , Hanratty Barbara , Hockley Jo , McKenzie Maisie , Soulsby Irene , Ogden Margaret 
Published: May 2024

AbstractPatient and public involvement and engagement (PPIE) is an increasingly important component of research conduct to enhance processes and potential for impact, yet is rarely critically interrogated. This paper draws on Foucauldian analysis to highlight the disciplinary powers and tensions arising in PPIE. The paper draws on a nested evaluation interview study with three PPIE members and eight academics, who had been involved in an implementation science study focused on palliative care. PPIE members were involved in the whole study and are co‐authors of this article. Through shared values and commitments to the study, a team culture of equality was developed. Yet while power was dispersed and taken‐up by all team members, in so doing a self‐governance approach within the team was developed. The pace and focus of discussions was at times more subjugating than co‐production. Identities and positions were porous; the simplistic division of ‘academic’ and ‘PPIE’ did not stand up to scrutiny, with an increasing blurring of boundaries as people’s experiences and insights changed over time. Continual, subtle, negotiations of roles, inputs and identities were manifest throughout the project. PPIE in research involves subtle, complex and ongoing disciplinary practices enacted by all members of the team.
THE HOUSING‐WELFARE REGIME AND THIRD‐SECTOR HOUSING IN HONG KONG AND SOUTH KOREA: A Historical Institutionalist Perspective
Authors: Seo Bo Kyong , Kim Dayoon 
Published: May 2024

AbstractThe third sector has recently emerged, or re‐emerged, as a new housing provider for disadvantaged groups in Hong Kong and Korea, where affordable housing development has been predominantly directed by government. However, our knowledge of third‐sector housing in non‐Western contexts remains partial. In this article, we aim to provide, from a historical‐institutionalist perspective, a comparative account of the (re‐)emergence and implementation of third‐sector affordable housing delivery in Hong Kong and Korea. Based on the housing‐welfare regime framework, we discuss the socioeconomic and political contexts in which third‐sector housing has burgeoned in the two regions, and how the relationship between the government and the third sector has moulded the implementation of third‐sector housing. We highlight the significant power of the government in implementing third‐sector housing and third‐sector organizations’ continued complementary role to the government in supplying housing as welfare, which reflects the path‐dependent nature of housing and welfare policies in the two regions. Adopting a long view to understanding history and a broader framework that reflects the socioeconomic context contributes to advancing the comparative housing literature.
Psychology as a Science of the Soul: Evangelos Christou’s The Logos of the Soul (1963)
Authors: Kugelmann Robert 
Published: May 2024

AbstractAfter Evangelos Christou (1923–1956) studied philosophy at King’s College, Cambridge, with Wittgenstein and others, he earned a doctorate at the Jung Institute in Zürich. He then returned home to Alexandria, near which he died in a car crash. The Logos of the Soul, published posthumously, argued for a psychology that would be neither a natural scientific psychology, devoted to causal analyses, nor a philosophical discipline that analysed mental events. Psychology would be an autonomous science of the soul, an unknown distinct from body and mind. Science deals with bodies and behaviours; philosophy with the mental concepts and acts. Psychology deals with “psychological experience”. Dreams and fantasies can be sources of psychological experience, but so can perceptual acts and mental acts. Meaning occurs when something encounters an ego or self in a psychological experience. Observation in psychology is participant observation, akin to witnessing of a drama. Psychological methods, such as psychotherapy, are both means of discovery and means of becoming. Christou’s work brought together Jung’s analytical psychology and mid‐century British philosophy in order to stake out the ground for psychology that would be an empirical analysis of psychological experience and a logical analysis of the concepts used in that psychology.
Addressing the safety of new food sources and production systems
Authors: Tan Yong Quan , Ong How Chee , Yong Adeline Mei Hui , Fattori Vittorio , Mukherjee Keya 
Published: May 2024

AbstractNew food sources and production systems (NFPS) are garnering much attention, driven by international trade, changing consumer preferences, potential sustainability benefits, and innovations in climate‐resilient food production systems. However, NFPS can introduce new challenges for food safety agencies and food manufacturers. Most food safety hazards linked to new foods have been identified in traditional foods. However, there can be some food safety challenges that are unique to new foods. New food ingredients, inputs, and processes can introduce unexpected contaminants. To realize the full potential of NFPS, there is a need for stakeholders from governments, the food industry, and the research community to collectively work to address and communicate the safety of NFPS products. This review outlines known food safety hazards associated with select NFPS products on the market, namely, plant‐derived proteins, seaweeds, jellyfish, insects, microbial proteins, as well as foods derived from cell‐based food production, precision fermentation, vertical farming, and 3D food printing. We identify common elements in emerging NFPS regulatory frameworks in various countries/regions. Furthermore, we highlight current efforts in harmonization of terminologies, use of recent scientific tools to fill in food safety knowledge gaps, and international multi‐stakeholder collaborations to tackle safety challenges. Although there cannot be a one‐size‐fits‐all approach when it comes to the regulatory oversight for ensuring the safety of NFPS, there is a need to develop consensus‐based structured protocols or workflows among stakeholders to facilitate comprehensive, robust, and internationally harmonized approaches. These efforts increase consumers’ confidence in the safety of new foods and contribute toward fair practices in the international trade of such foods.
Rapid determination of starch and alcohol contents in fermented grains by hyperspectral imaging combined with data fusion techniques
Authors: Liang Yan , Tian Jianping , Hu Xinjun , Huang Yuexiang , He Kangling , Xie Liangliang , Yang Haili , Huang Dan , Zhou Yifei , Xia Yuanyuan 
Published: May 2024

AbstractStarch and alcohol serve as pivotal indicators in assessing the quality of lees fermentation. In this paper, two hyperspectral imaging (HSI) techniques (visible–near‐infrared (Vis–NIR) and NIR) were utilized to acquire separate HSI data, which were then fused and analyzed toforecast the starch and alcohol contents during the fermentation of lees. Five preprocessing methods were first used to preprocess the Vis–NIR, NIR, and the fused Vis–NIR and NIR data, after which partial least squares regression models were established to determine the best preprocessing method. Following, competitive adaptive reweighted sampling, successive projection algorithm, and principal component analysis algorithms were used to extract the characteristic wavelengths to accurately predict the starch and alcohol levels. Finally, support vector machine (SVM)‐AdaBoost and XGBoost models were built based on the low‐level fusion (LLF) and intermediate‐level fusion (ILF) of single Vis–NIR and NIR as well as the fused data. The results showed that the SVM‐AdaBoost model built using the LLF data afterpreprocessing by standard normalized variable was most accurate for predicting the starch content, with an of 0.9976 and a root mean square error of prediction (RMSEP) of 0.0992. The XGBoost model built using ILF data was most accurate for predicting the alcohol content, with an of 0.9969 and an RMSEP of 0.0605. In conclusion, the analysis of fused data from distinct HSI technologies facilitates rapid and precise determination of the starch and alcohol contents in fermented grains.
Diversity in Pyracantha fortuneana fruits maturity stages enables discrepancy in the phenolic compounds, antioxidant activity, and tyrosinase inhibitory activity
Authors: Wang Yan , Shao Qiju , Yang Xijin , Su Ke , Li Zhirong , Yang Yuyao , Yuan Xiaoyan , Chen Rongxiang 
Published: May 2024

AbstractPyracantha fortuneana (P. fortuneana) fruit is a wild fruit that is popular because of its delicious taste and numerous nutrients, and phenolic compounds are considered to be the main bioactive components in P. fortuneana fruits. However, the relationship between phenolic compounds and their antioxidant and tyrosinase (TYR) inhibitory activities during the ripening process is still unclear. The study compared the influence of the five developmental stages on the accumulation of phenolic compounds, antioxidant activity, and TYR inhibitory activity in the fruits of P. fortuneana. The compounds were identified by offline two‐dimensional liquid chromatography‐electrochemical detection (2D‐LC‐ECD) combined with liquid chromatography–tandem mass spectrometry, and the main active ingredients were quantified. The results showed that stage II had higher total phenolic and flavonoid content, as well as higher antioxidant and TYR inhibitory activity, but the total anthocyanin content was lowest at this stage. A total of 30 compounds were identified by 2D‐LC‐ECD. Orthogonal partial least squares discriminant analysis screened out six major potential markers, including phenolic acids, procyanidins, and flavonoids. In addition, it was found that caffeoylquinic acids, procyanidins, and flavonoids were higher in stage II than in stages I, III, IV, and V, whereas anthocyanins accumulated gradually from stages III to V. Therefore, this study suggests that the changes in antioxidant and TYR inhibitory activities of P. fortuneana during the five developmental stages may be due to the transformation of procyanidins, caffeoylquinic acids, and phenolic glycosides into other forms during the fruit maturation process.Practical Application: Differences in chemical constituents, antioxidant, and tyrosinase inhibitory activities in fruit maturity stages of P. fortuneana were elucidated to provide reference for rational harvesting and utilization of the fruits and their bioactive components. These findings are expected to provide a comprehensive assessment of the bioactive profile and guide the food industrial production.
Causal association between autoimmune liver disease and Sjögren's syndrome: A Mendelian randomization study
Authors: Li Yixuan , Wang Jing , Jiang Huan , Zhang Ju , Qi Jiaping , Jiang Zhaoyu , Chen Lin , Ying Zhenhua 
Published: May 2024

AbstractBackgroundObservational studies have found an association between autoimmune liver disease (AILD) and Sjögren's syndrome (SS). However, the causal relationship between the two remains unknown. Clinical guidelines indicate that the coexistence of AILD with other autoimmune diseases may impact prognosis and quality of life; hence, early recognition and management of extrahepatic autoimmune diseases is particularly crucial. Against this backdrop, this study aimed to utilize Mendelian randomization (MR) methods to investigate the potential causal relationship between AILD and SS.MethodsWe extracted summary statistics on AILD and SS from publicly available genome‐wide association studies (GWAS) databases to identify appropriate instrumental variables (IVs). The inverse‐variance weighted (IVW) method was utilized as the primary approach, with the weighted median (WM) method and MR‐Egger method employed as supplementary methods to evaluate the potential causal relationship between the two conditions. Sensitivity analyses, including Cochran's Q test, MR‐polynomial residuals and outliers (MR‐PRESSO), MR‐Egger intercept test, and the leave‐one‐out test, were performed to assess the stability of the results.ResultsThe MR study results indicate a significant causal relationship between PBC and PSC with the risk of SS in the European population (IVW: odds ratio [OR] = 1.155, 95% confidence interval [CI]: 1.092–1.222, p < .001; IVW: OR = 1.162, 95% CI: 1.051–1.284, p = .003). A series of sensitivity analyses have confirmed the reliability of the results.ConclusionsOur study indicates that the presence of both PBC and PSC increases the susceptibility to SS. However, no reliable causal relationship was found between SS and the risk of PBC or PSC. These findings contribute to elucidating the potential pathogenic mechanisms of the disease and are of significant importance for the management of patients with PBC and PSC.
Assessment and comparison of the 2023 ACR/EULAR APS criteria with the revised Sapporo criteria
Authors: Vasi İbrahim , Kardaş Rıza Can , Ekici Mustafa , Yıldırım Derya , Kaya Burcugül , Duran Rahime , Karadeniz Hazan , Güler Aslıhan Avanoğlu , Küçük Hamit , Göker Berna , Bilgen Şule Apraş , Tufan Abdurrahman , Öztürk Mehmet Akif , Erden Abdulsamet 
Published: May 2024

AbstractObjectiveTo analyze antiphospholipid antibody (aPL)‐positive patients using the 2023 American College of Rheumatology/The European Alliance of Associations for Rheumatology (ACR/EULAR) antiphospholipid syndrome (APS) classification criteria and compare the revised Sapporo criteria and the 2023 ACR/EULAR criteria and evaluate whether the 2023 ACR/EULAR criteria provide added value over the revised Sapporo criteria.MethodsIn this descriptive study, 94 aPL‐positive patients (with or without APS diagnosis) were identified from two hospital‐based registries (Gazi and Hacettepe University). Patients were classified into four groups to compare both criteria sets. These four groups are as follows: (1) patients classified with only the revised Sapporo criteria; (2) patients classified with only the 2023 ACR/EULAR APS criteria; (3) patients classified with both two criteria sets; and (4) patients classified with neither two criteria set.ResultsOf the 94 patients, 11 were classified with only the revised Sapporo criteria; one with only the 2023 ACR/EULAR APS criteria; 52 with both criteria sets; and 30 with neither set of criteria. For these 94 patients, the operating characteristics of the 2023 ACR/EULAR APS criteria, using the revised Sapporo criteria as the gold standard, the 2023 ACR/EULAR APS entry criteria demonstrated 100% sensitivity, and the 2023 ACR/EULAR APS classification criteria demonstrated 98% specificity and 82.5% sensitivity.ConclusionThe study emphasizes the importance of recognizing differences in clinical manifestations, such as early pregnancy loss without severe preeclampsia (PEC) and/or severe placental insufficiency (PI) and calls for a nuanced discussion on anticardiolipin (aCL) and anti‐beta 2‐glycoprotein‐I (anti‐β2GPI) immunoglobulin G (IgG) cutoff values.
Argentina and the Ukraine War: Between pragmatism and values
Authors: Binetti Bruno 
Published: May 2024

AbstractThis article examines Argentina's stance regarding Russia's invasion of Ukraine. During the administration of President Alberto Fernández (2019–2023), Argentina condemned the invasion at the United Nations but maintained a relatively low diplomatic profile and criticised Western sanctions against Russia. However, since President Javier Milei took office in late 2023, Argentina has shifted its foreign policy orientation towards greater alignment with Western powers, leading to a more unequivocal support of Ukraine. As a significant development, President Zelensky responded by attending Milei's inauguration. The evolution of Argentina's position results from a combination of strategic calculation and principles across administrations of different ideological orientations, contradicting simplistic views of the international stance of Global South countries.
Remimazolam for sedation and anesthesia in children: A scoping review
Authors: Kuklin Vladimir , Hansen Tom G. 
Published: May 2024

AbstractBackgroundRemimazolam, a novel intravenous benzodiazepine recently approved by both the European Medicines Agency and the Food and Drug Agency, shows considerable promise in clinical practice. Its pharmacodynamic profile closely resembles that of midazolam, while its pharmacokinetic properties are similar to those of remifentanil. While research in adult populations continues to accumulate, the pace of pediatric studies is not as significant.This scoping review aims to systematically examine published studies, clinical trials, observational research, case reports, and relevant literature to provide a comprehensive understanding of remimazolam in pediatric sedation and anesthesia. By synthesizing the gathered evidence, we aim to identify gaps in the literature, guide future research endeavors, and inform clinical practices.MethodsThe review follows the guidelines outlined by the Preferred Reporting Items for Systematic Review and Meta‐Analysis for Scoping Review. A thorough search strategy was implemented across prominent peer‐reviewed databases, with focused efforts to identify relevant grey literature. All primary studies involving the use of remimazolam in pediatric populations were included in this review.ResultsEighteen studies were included in this analysis, comprising 2 randomized controlled trials, 4 prospective cohort trials, 12 case reports, and 692 children in total.ConclusionThis scoping review highlights the increasing interest in using remimazolam as a sedative or anesthetic for children. Although initial evidence indicates its effectiveness and safety, more research is necessary to fill knowledge gaps, establish standard protocols, and optimize its use in pediatric anesthesia and sedation. Addressing these challenges will enable clinicians to improve the quality of care and outcomes for pediatric patients undergoing sedation and anesthesia.
Clinical features of individuals with laboratory values suggestive of advanced liver fibrosis when first treated for alcohol use disorder
Authors: Zuluaga Paola , Fuster Daniel , Blanes Rafael , Hernández‐Rubio Anna , Miquel Laia , Torrens Marta , Rubio Gabriel , Bolao Ferrán , Liangpunsakul Suthat , Abellí‐Deulofeu Enric , Rodriguez de Fonseca Fernando , Muga Robert ,   CohRTA
Published: May 2024

AbstractBackgroundEffective screening for alcohol‐associated liver disease is relevant in the context of chronic, excessive alcohol consumption. Patients with alcohol‐associated liver disease are often not diagnosed until their liver disease is decompensated. We analyzed the prevalence and associations of Fibrosis‐4 index (FIB‐4) values suggestive of advanced liver fibrosis in patients referred for their first treatment of alcohol use disorder (AUD).MethodsWe conducted a cross‐sectional, multicenter study of noncirrhotic individuals referred for their first AUD treatment between March 2013 and April 2021. We obtained sociodemographic data, substance use characteristics, and blood samples at admission. We considered a FIB‐4 value ≥2.67 suggestive of advanced liver fibrosis and used logistic regression analyses to identify features associated with this value.ResultsWe included 604 patients (67% male), with a median age at admission of 48 years [IQR: 41–56 years]. The median duration of regular alcohol consumption was 21 years [IQR: 18–30 years] and the median alcohol consumption was 105 standard drink units (SDU)/week [IQR: 63–160 SDU/week]. A FIB‐4 value ≥ 2.67 was present in 19.3% of cases. These patients reported more frequent binge drinking (75.4% vs. 66%, p = 0.05) than those with FIB‐4 values below 2.67. In multivariate analysis, a history of binge drinking (OR 1.9, 95% CI, 1.05–3.47), anemia (OR 2.95, 95% CI, 1.42–6.11), leukopenia (OR 7.46, 95% CI, 2.07–26.8), and total serum bilirubin >1 mg/dL (OR 6.46, 95% CI, 3.57–11.7) were independently associated with FIB‐4 values ≥2.67.ConclusionsOne in five patients admitted to treatment for AUD without evidence of decompensated liver disease have FIB‐4 values suggestive of advanced liver fibrosis. The presence of a binge drinking history, anemia, leukopenia, and elevated bilirubin levels is associated with high FIB‐4 values.
Association of systemic chronic inflammation during pregnancy in different periods and its trajectories with preterm birth
Authors: Cheng Haoyue , Zhu Zhe , Chi Peihan , Alifu Xialidan , Zhuang Yan , Si Shuting , Qiu Yiwen , Zhou Haibo , Peng Zhicheng , Yu Yunxian 
Published: May 2024

AbstractProblemSystemic chronic inflammation (SCI) is a prevalent characteristic observed in various diseases originating from different tissues, while the association of SCI with preterm birth (PTB) remains uncertain. This study aimed to analyze the association between a nonspecific biomarker of SCI and PTB, while also exploring the trajectories of SCI in pregnant women at risk of PTB.Method of studyThe study used data from the Electronic Medical Record System (EMRS) of a hospital in Zhejiang, China and 9226 pregnant women were included. The duration of pregnancy was categorized into four distinct periods: the first, early‐second, late‐second, and third trimester. Latent class trajectory modeling (LCTM) was used to identify the trajectories of SCI during pregnancy.ResultsThe elevated WBC counts in the late‐second (OR = 1.14, 95% CI: 1.06–1.23) and third (OR = 1.16, 95% CI: 1.09–1.24) trimester were both positively associated with an evaluated risk of PTB. Moreover, significant dose–response relationships were observed. There were three distinct SCI trajectories found: progressing SCI (2.89%), high SCI (7.13%), and low SCI (89.98%). Pregnant women with progressive SCI had the highest risk of PTB (OR = 3.03, 95% CI: 1.47–6.25).ConclusionsIn conclusion, elevated SCI after 23 weeks was a risk factor for PTB in healthy women, even if the SCI indicator was within normal range. Pregnant women with progressive SCI during pregnancy had the highest risk of PTB.
The costs of war: Lessons from a public scholarship project on the post‐9/11 wars
Authors: Savell Stephanie , Lutz Catherine 
Published: May 2024

AbstractThis article lays out the work of Costs of War, a project of scholars creating public‐facing knowledge toward the goal of challenging US militarism. Emerging from literature that critiques US imperial violence and deconstructs the commonplace understandings that support it, our efforts identify and confront pillars of belief about war that are shaped by the powerful military‐industrial complex and rooted in an underlying devaluation of the lives of Muslims, people of color, women, and oppressed groups who bear the brunt of militarization both at home and abroad. We use our research and associated website (costsofwar.org) to reach out to journalists, editors, Congress, policymakers, civic groups, social movements, and the US public. In contesting the soundbites about the post‐9/11 wars that allow these wars to be seen as inevitable and to continue uncontested, we hope to help avert the next war championed by those least likely to live with the horrific and decades‐long consequences. We describe our approach, its successes, and its stumbling blocks in hope of offering insights for scholars in the social sciences who wish to use their research in service of activist goals and social justice movements, antiwar and beyond.