bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered kinematics and coordination patterns of adjacent joints after anterior cruciate ligament injury
Authors: Wu Danni , Hu Mengling , Li Zhuman , Deng Qian , Zhang Ling , Luo Ye , Li Jian , Wang Shaobai 
Published: June 2024

Abstract

Purpose
Anterior cruciate ligament (ACL) injuries typically demonstrate abnormal motion in multiple planes of the joints. The objective of this study is to investigate the kinematic properties of the knee and ankle joints in patients who have suffered ACL injuries. The alterations in knee-ankle coordination patterns after ACL injury will alsobe evaluated.
Methods
Thirty participants diagnosed with unilateral complete ACL rupture through MRI were included in the study. An optical tracking device was used to measure each joint's kinematics during treadmill gait. Kinematic parameters and joint ranges of motion of participants' knees and ankles were compared. The mean absolute relative phase (MARP) and deviation phase (DP) were further calculated for comparison.
Results
(1) Knee kinematics: The flexion, external rotation , abductionand lateral translation of the ACL injured knee joint increased during the stance phase. The abduction increased during the swing phase, while the anterior translation and proximal translation decreased. (2) Ankle kinematics: The ankle joints of patients with ACL injuries showed increased external rotation during the stance phase and increased plantarflexion and external rotation during the swing phase. (3) The MARP and DP of ACL-injured patients decreased during the stance phase and increased in the swing phase.
Conclusion
The findings suggest that ACL injury may alter ankle kinematics in addition to knee kinematics. This leads to adaptive alterations in knee-ankle coordination as well as coordination variability.
Dynamic Object Recognition and Robot Grasping using CNN-BiLSTM with integration of Double-DQN
Authors: Soumyashree Soumyashree , Singh Gurmeet , Gill Harjot Singh 
Published: June 2024

Abstract

This study introduces a novel object recognition algorithm employing the CNN-BiLSTM technique. Through the integration of advanced sensory technologies and deep reinforcement learning approaches, the proposed system dynamically adjusts its detection parameters to accommodate diverse object geometries, sizes, and surface properties. The approach entails training a neural network agent to discern, from an image window, which objects within a predetermined region warrant focused attention. To effectively handle high-dimensional and time-series data, a Double DQN framework is utilized. The proposed approach amalgamates object recognition algorithms with sophisticated reinforcement learning techniques, notably Double DQN, enabling robots to dynamically perceive and grasp items in varied environments. The outcomes were obtained by conducting comparative research to evaluate the effectiveness of current approaches in comparison to the proposed method. The Q-network is trained to execute two distinct motions, namely "twist" and "push," with the intended motion provided as an assigned parameter (+1 for "push" and-1 for "twist"). Moreover, the network can generate intermediate movements between the learned motions when the task parameter falls between-1 and +1. The findings reveal notable enhancements in grasping success rates and adaptability across diverse item sizes, shapes, and conditions. Notably, the study reports a significant increase in the task completion rate for grasping, achieving a success rate of 90%.
TNF-α and RPLP0 driving apoptosis of endothelial cells as the shared molecular mechanism of high altitude pulmonary edema in sojourners and natives: bioinformatic analysis and experimental validation
Authors: Ge Yi-Ling , Li Pei-Jie , Bu Ying-Rui , Zhang Bin , Xu Jin , He Si-Yuan , Cao Qing-Lin , Bai Yun-Gang , Ma Jin , Zhang Lin , Liu Yong , Xie Man-Jiang 
Published: June 2024

Abstract

High altitude pulmonary edema (HAPE) is a fatal threat for those sojourners who ascend rapidly without sufficient acclimatization. High altitude natives are insusceptible to HAPE resulting from evolved genetic specializations of adaption. In this study, based on GSE52209, the gene expression profile of HAPE patients was compared with acclimatized sojourners and adapted natives, with the common and divergent differential expressed genes (DEGs) and their hub genes being identified, respectively. Bioinformatic methodologies of functional enrichment analysis, immune infiltration, diagnostic model constructing, ceRNAs and drugs predicting, were performed to detect the potential biological functions and molecular mechanisms. Next, an array of in-vivo experiments in HAPE rat model and in-vitro experiments in HUVECs were conducted to verify the results of bioinformatic analysis. Enriched pathways of DEGs and immune landscapes for HAPE exhibited significant differences between sojourners and natives, and the common DEGs were mainly enriched in the pathways of development and immunity. Nomograms found the upregulation of TNF-α and downregulation of RPLP0 exhibited high diagnostic efficiency for HAPE both in sojourners and natives, which was furtherly validated in the HAPE rat model. Treatment of TNF-α and knock-down of RPLP0 activated apoptosis signaling in endothelial cells (ECs) and enhanced endothelial permeability. Conclusively, TNF-α and RPLP0 are identified as the shared biomarkers and molecular basis for HAPE during the acclimatization/adaption/maladaptation processes in sojourners and natives, which inspire new ideas for the prediction and treatment of HAPE.
CFIR Model for Exploring the Role of Co-creation in the Implementation of Electronic Community Health Information System (eCHIS) in Kenya
Authors: Anindo Michael , Waiganjo Peter , Orwa Daniel , Kagiri Michael , Ireri Salome , Adoyo Maureen , Wanjiru Rachael , Kirui Joan , Pundo Raphael , Kimani Maureen 
Published: June 2024

Abstract

The successful implementation of an Electronic Community Health Information System (eCHIS) in Kenya is pivotal for enhancing healthcare delivery. This study explores the role of co-creation in the implementation of eCHIS, focusing on achieving adaptability, interoperability, and standardization. We employed semi-structured interviews with key informants, including policymakers, implementing partners, and end users. The Consolidated Framework for Implementation Research (CFIR) guided our thematic analysis. Key findings indicate that co-creation facilitated consensus and synergy among stakeholders. The construct of adaptability was highlighted through the customization of eCHIS to meet diverse needs, as reflected in the stakeholders' emphasis on real-time data access and policy-driven evidence. Interoperability was achieved through collaborative efforts to integrate eCHIS with existing health systems, supported by unified standards and protocols. Standardization efforts were underscored by the establishment of uniform data collection and reporting practices across all counties. Stakeholders perceived strong political support and leadership as critical to overcoming implementation challenges. Effective collaboration, continuous training, and capacity building were identified as essential for sustaining the system. The study also revealed that end users, including community health assistants and promoters, felt confident in their ability to utilize eCHIS, attributing this to comprehensive training and support structures. The co-creation approach significantly contributed to the successful implementation of eCHIS in Kenya by fostering adaptability, interoperability, and standardization. These findings underscore the importance of collaborative frameworks in health information system deployments, aligning with broader literature on co-creation and health systems strengthening.
Food consumption patterns and cardiovascular risk among shift workers: A NOVA-based approach
Authors: Silva Andressa Santana Serra , Ribeiro Silvana Mara Luz Turbino , de Freitas Sílvia Nascimento , Pimenta Fausto Aloisio Pedrosa , Machado-Coelho George Luiz Lins , de Oliveira Fernando Luiz Pereira , Neto Raimundo Marques do Nascimento , de Menezes-Júnior Luiz Antônio Alves 
Published: June 2024

Abstract

Objective: To evaluate the association between food consumption, by extent and purpose of processing, and cardiovascular disease (CVD) risk among rotating shift workers.
Methods: The cross-sectional study included 213 male shift workers. Dietary intake was assessed using a 24-hour recall method conducted by trained interviewers. Food items were classified using two approaches: the first was based on the quantity consumed from each food group. Fruits and vegetables (FV) intake, is classified as recommended at 400g per day by WHO guidelines. Ultraprocessed foods (UPFs) were analyzed based on tertiles of daily caloric contribution. The second approach, the NOVA dietary diversity score (DDS-NOVA) assessed the variety of consumed items within each food group, assigning points for each unique item consumed, irrespective of quantity or frequency. The CVD risk was evaluated using the Framingham coronary heart disease risk score (FCRS), categorizing participants as low risk (<5%) or intermediate to high risk (>5%). Descriptive, univariate, and multivariate logistic regression were used.
Results: CVD-risk was classified as high in 43.7%. In the multivariate model, the recommended consumption of FV was associated with a lower chance of high CVD-risk (OR:0.47;95%CI:0.23-0.98), and there was no association between the amount of UPF consumption and CVD-risk. In terms of variety, fresh-food consumption was associated with a lower chance of high CVD-risk (OR:0.67;95%CI:0.23-0.98), and UPF consumption was associated with higher CVD-risk (OR:1.30;95%CI:1.12-1.87).
Conclusion: Consumption of both variety and quantity of fresh-foods was associated with a lower chance of CVD-risk, while a variety of consumption of UPF items increased this chance.
Closing the internal opening with a rectal advancement flap increases the efficacy of mesenchymal stem-cell injection for complex Crohn's disease anal fistulas
Authors: Fathallah Nadia , Haouari Mohamed Amine , Alam Amine , Barré Amélie , Roland Déborah , Spindler Lucas , Far Eric Saf , de Parades Vincent 
Published: June 2024

Abstract

Background
The efficacy of injections of mesenchymal stem cells (MSC) for anal fistula treatment may be impaired by the persistence of stools passing into the fistula, causing bacterial contamination and a local inflammatory reaction. We aimed to compare remission rates between patients treated by MSC injection with simple sutures and those treated with a rectal advancement flap.
Methods
This single-center prospective study compared the first patients who underwent internal opening closure with sutures, with the subsequent patients treated with a flap. Complete clinical remission was defined as complete closure of the external opening(s) without pain or discharge, and complete radiological remission was defined as a Magnifi-CD score of 0.
Results
We compared the first 42 patients who had sutures with the 20 subsequent patients who had an advancement flap. The median follow-up was 15.5 months [8.8–24.9 months]. The cumulative incidence of complete clinical response at M12 was 53.8% [38.1–69.6%] in the suture group versus 93.3% [77.4–100.0] in the flap group (p < 0.001). The Magnifi-CD score was 0 for 72.7% [39.0%-63.9%]) of patients treated with a flap versus 41.7% [25.5%-59.2%]) of patients treated with sutures (p = 0.093). Anal incontinence score did not differ between the 2 groups. Practicing an advancement flap was the only significant factor associated with complete clinical remission over time (adjusted HR [95% CI] of 2.6 [1.4–4.9], p = 0.003).
Conclusions
Complete clinical remission rates following MSC injection are significantly higher for the closure of the internal opening with a rectal flap than for closure with sutures, with no consequences for anal continence.
Seasonal Prevalence and Risk Factors of canine Leishmania Infection in Beijing, China
Authors: Chen Yujuan , Tang Han , Yu Yonglan 
Published: June 2024

Abstract

Background
Leishmaniasis, a severe zoonotic disease where dogs act as the main reservoir for Leishmania infantum (L. infantum), poses a significant public health threat. Despite recent cases in Beijing, China, there is a lack of comprehensive studies on canine leishmaniasis (CanL) in this region. This study aimed to determine the prevalence of CanL in Beijing and identify associated risk factors.
Methods
Enzyme-linked immunosorbent assay (ELISA) was used to detect anti-L. infantum antibodies, and quantitative real-time PCR (qPCR) was used to identify Leishmania DNA. The study included 737 dogs: 575 were tested with both ELISA using serum samples and qPCR using whole blood samples, while the remaining 162 were tested only with qPCR. Variables related to the dogs were collected and evaluated through univariate analysis (the Chi-square test) and multivariate logistical regression analysis. For dogs that tested positive on ELISA or qPCR and exhibited suspicious clinical symptoms, we collected lymph node punctures and skin scrape material to reconfirm Leishmania infection by qPCR.
Results
ELISA and qPCR prevalence rates were 4.87% (28/575) and 3.26% (24/737), respectively, with all qPCR-positive samples confirmed as L. infantum by PCR amplification of the internal transcribed spacer (ITS) gene. QPCR and ELISA demonstrated strong consistency (P = 0.00) in detecting Leishmania among the 575 dogs subjected to both tests. Multivariate analysis revealed a higher prevalence of CanL during springtime in Beijing (ELISA: OR = 9.31, 95% CI = 2.75–31.47; qPCR: OR = 7.22, 95% CI = 2.49–20.94), and among younger dogs (0-2Y) (ELISA: OR = 5.49, 95% CI = 1.70–17.80; qPCR: OR = 4.51, 95% CI = 1.25–16.24). Univariate analysis identified suburban areas (P = 0.02) and medium to large-sized dogs (P = 0.00) as secondary risk factors. Among the dogs that tested positive on ELISA or qPCR, 16 were subsequently confirmed to have CanL through qPCR test of lymph node aspirates and skin scrapings. The majority of these cases were found in suburban areas (68.75%), with 43.75% detected during springtime. Additionally, 50% of the cases involved medium-sized dogs.
Conclusion
Seroprevalence and molecular prevalence of CanL in Beijing was 4.87% and 3.26% respectively, with a higher prevalence observed in spring and among younger dogs (0-2Y), emphasizing the importance of comprehensive studies to address public health threats.
Elucidation of the mechanism of c-Myc expression in invasive ductal breast cancer using fluorescence in situ hybridization
Authors: Takishita Mariko Nagai , Koike Junki , Saito Kanna , Ito Kazuki , Yamada Miyako , Sugiyama Runa , Arihara Taku , Sakamaki Kaori , Kakimoto Sayoko , Kitajima Mina , Tazo Mizuho , Nakano Mari Hara , Kuroda Takako , Motoyoshi Ai , Nishikawa Toru , Kawamoto Hisanori , Fukuda Mamoru , Tsugawa Koichiro 
Published: June 2024

Abstract

Certain breast cancer treatments are ineffective and develop drug resistance in some cases. In various cancers, the c-Myc protein plays a critical role in cell proliferation regulation and cell cycle control, promoting carcinogenesis and treatment resistance. High c-Myc protein expression is in 30–50% of high-grade breast tumors. This study focused on examining the relationship between c-Myc protein expression and c-myc gene amplification in triple-negative breast cancer (TNBC) compared with other invasive ductal carcinomas. We performed c-Myc immunohistochemistry and c-myc fluorescence in situ hybridization on 108 invasive ductal carcinoma cases, which had not received preoperative treatment and were resected between January 2019 and December 2021. The proportion of TNBC increased in the group with high c-Myc expression within invasive ductal carcinoma. Fluorescence in situ hybridization divided cases with high c-Myc protein expression into those with and without c-myc gene amplification, suggesting that c-Myc protein expression in breast cancer is induced by c-myc gene amplification. Additionally, cases of high c-Myc protein expression might result from tumor cell polyploidization and epigenomic factors. Given that c-Myc protein is associated with breast cancer malignancy and treatment resistance, determining gene amplification presence or absence can be crucial in developing breast cancer prognostic and treatment strategies.
Continuous-variable Quantum Boltzmann Machine
Authors: Bangar Shikha , Sunny Leanto , Yeter-Aydeniz Kubra , Siopsis George 
Published: June 2024

Abstract

We propose a continuous-variable quantum Boltzmann machine (CVQBM) using a powerful energy-based neural network. It can be realized experimentally on a continuous-variable (CV) photonic quantum computer. We used a CV quantum imaginary time evolution (QITE) algorithm to prepare the essential thermal state and then designed the CVQBM to proficiently generate continuous probability distributions. We applied our method to both classical and quantum data. Using real-world classical data, such as synthetic aperture radar (SAR) images, we generated probability distributions. For quantum data, we used the output of CV quantum circuits. We obtained high fidelity and low Kuller-Leibler (KL) divergence showing that our CVQBM learns distributions from given data well and generates data sampling from that distribution efficiently. We also discussed the experimental feasibility of our proposed CVQBM. Our method can be applied to a wide range of real-world problems by choosing an appropriate target distribution (corresponding to, e.g., SAR images, medical images, and risk management in finance). Moreover, our CVQBM is versatile and could be programmed to perform tasks beyond generation, such as anomaly detection.
Bilateral exudative retinal detachment with subretinal light-chain protein in a patient with multiple myeloma
Authors: Gruben Arved Rikus , Ehlken Christoph , Roider Johann 
Published: June 2024

Abstract

Background: Exudative retinal detachment in patients with multiple myeloma is exceedingly rare. Only two Cases are known to us. We successfully identified light-chain proteins in subretinal fluid, allowing for a more precise understanding of the pathogenesis of this complication.
Case presentation: A 68-year-old patient presented with bilateral exudative retinal detachment. The visual impairment was reported one day after stem cell mobilization by granulocyte-conlony stimulating factor (G-CSF) and the additional administration of Plerixafor. The symptoms began during stem cell apheresis. The patient underwent surgical treatment for both eyes through vitrectomy and silicone oil tamponade. Light-chain proteins were detected in the collected subretinal fluid through electrophoresis in one eye.
Conclusions: We successfully identified light-chain proteins in subretinal fluid, allowing for a more precise understanding of the pathogenesis of this complication. The pathomechanism likely involves damage to the outer blood-retina barrier due to the deposition of light-chain proteins. Whether mobilization of bone marrow cells with Plerixafor led to a breakdown of the outer blood-retina barrier in these patients is a topic for discussion and has to be considered in the use of Plerixafor.
Evaluation of the efficacy of a brief mindfulness-based intervention on state-rumination and stress response of medical students following an exam: A randomized controlled study
Authors: Guillaumée Théodore , Lutz Antoine , Duclos Antoine , Rimmelé Thomas , Barret Noémie , Berland Alexandre , Rode Gilles , Lilot Marc , Schlatter Sophie 
Published: June 2024

Abstract

Background:
To prevent the medical students from a deleterious psychophysiological activation, it is necessary to provide them a large variety of stress management techniques. The primary aim was to assess the efficacy of a short Mindfulness-Based Intervention (MBI) to reduce state-rumination following an exam (Objective Structured Clinical Examination: OSCE). The second aims were to assess the efficacy of the short MBI to reduce stress-response and to identify the determinants of state-rumination.
Methods:
Students were randomly allocated to two parallel groups: 6-minute MBI or 6-minute control video. Levels of state-rumination (Brief State-Rumination Inventory) and stress-response (psychological and physiological markers) were assessed. Feelings during the video were reported. OSCE performance, gender, sleep quality, and sport practice were assessed. Participants were blinded to the group assignment, but the administrators and outcome assessors were not. NCT05390879.
Results:
Four hundred eighty-two students participated (n = 239 in MBI and n = 243 in Control). Rumination did not differ between the groups (∆BSRIMBI -5 ± 12, ∆BSRIControl -5 ± 13, ∆BSRI t-test − 0.38 95% CI [-2.61:1.86], p = 0.740). The same applies to psychological stress (all p < 0.05). However, MBI students presented a lower physiological stress and reported more positive feelings during the video (all p < 0.05). Poor exam performance, female gender, poor sleep quality, and no sport practice were positively associated with state-rumination (all p < 0.05).
Conclusions:
MBI following an OSCE led to positive feelings and reduced physiological stress but neither psychological stress nor state-rumination. Performance, gender, sleep quality, and sport practice are determinants of state-rumination. This study offers insights that can inform the future development of specific interventions to reduce rumination in medical students.
A Volume Rendering Visualization Method Oriented to Explosion Field Features
Authors: Ning Jianguo , Zhao Haitao , Xu Xiangzhao 
Published: June 2024

Abstract

To observe the deformation and the failure process of solid objects in explosion and impact simulations, the clarity and accuracy of simulation image representations should be ensured. However, in the results of three-dimensional (3D) explosion field rendering, surface confusion and blurred images of the microstructure often lead to misunderstandings of the simulation results. In this work, based on the ray casting method and the Blinn-Phong lighting model, a volume rendering method is proposed that can adapt to the characteristics of step changes in the explosion field data and satisfies the requirements of observing the microstructure. The Blinn-Phong lighting model is applied to the light and shade calculation of the resampling point, and the gradient of the resampling point is obtained via interpolation calculations; then, it is normalized to obtain the normal vector. When calculating the material color of the resampling point, the transfer function calculation is performed first; then, the interpolation calculation is performed. Finally, the opacity of the resampling point and the associated material color are substituted into the ray casting synthesis formula.In addition, several groups of examples of visual effects are analyzed from the subjective point of view of human visual effects and the objective points of view of image entropy, the meangradient, image mean and standard deviation. The results show that the new method addresses the problem of interface color confusion, improves the accuracy of microstructure rendering in solid media, increases the spatial sense of visual images, and satisfies the visualization requirements for explosion products and shock waves. At the same time, this approach effectively shortens the time for volume rendering of the explosion field.