bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Application of BOth Sides Up Ball Training Combined With Resistance Training in Joint Stability Improvement Following Anterior Cruciate Ligament Reconstruction Surgery in Teenage Athletes
Authors: Cao Xiaodong , Liu Junlian , Zhao Jinwei , Feng Shuolei , Zhao Zijian 
Published: February 2025

Adolescent athletes participating in sports involving sudden directional changes, pivoting, and jumping frequently sustain anterior cruciate ligament (ACL) ruptures. ACL reconstruction (ACLR) surgery is often required, followed by a lengthy rehabilitation period. This study aims to evaluate the effectiveness of combining BOth Sides Up (BOSU) ball exercises with conventional resistance training in the recovery of joint stability and function after ACLR in adolescent athletes. Thirty adolescent athletes (ages 14–18) who underwent ACLR were randomly allocated to either the control group receiving traditional postoperative rehabilitation (n = 15) or the intervention group combining BOSU ball training with resistance exercises (n = 15). Joint stability, proprioception, strength, and functional outcomes were assessed before the procedure, as well as 3, 6, and 12 months after the operation using the KT-1000 arthrometer, Y-balance test, isokinetic dynamometry, and the ACL-Return to Sport after Injury ACL-Return to Sport after Injury (ACL-RSI) scale. The intervention group demonstrated notably better anterior-posterior knee joint stability (P < .05) than the control group at the 6-month and 12-month follow-ups after the surgery, greater reach distances in the Star Excursion Balance Test (P < .05), higher quadriceps and hamstring strength ratios (P < .05), and superior ACL-RSI scores (P < .01). Incorporating BOSU ball training with resistance exercises appears to be more effective than traditional rehabilitation alone in enhancing joint stability and neuromuscular control after ACLR in adolescent athletes. These results provide evidence supporting the incorporation of unstable surfaces into a comprehensive rehabilitation program to optimize recovery and safe return to sports.
Successful posthospitalisation oncology workflow implementing LACE+ score to stratify and reduce readmissions within a safety-net hospital
Authors: Pabon Cindy M , Wong Janine , Perez Marcela , Jimenez-Abarca Jessica , Xiao Lianchun , Jackson Lymesia , Park Anne , Lankford Anjali , Akula Vinita , Datar Saumil , Hopper Taylor , Alkhatib Yaser , Earles Terri , Patel Tejal 
Published: February 2025

BackgroundPatients with advanced cancers visit the emergency room and get hospitalised frequently, with potentially half of these visits being avoidable. Our institution provides comprehensive, low-cost cancer treatment to a safety-net population in Texas. We performed a retrospective review of hospital readmission patterns amongst our oncology patients and developed a posthospitalisation workflow to reduce readmissions.MethodFollowing discharge, oncology patients were risk stratified based on their Length of stay, Acuity of admission, Charlson comorbidity index score and Emergency department visits+index in the past 6 months. The higher the score, the quicker the outpatient oncology follow-up. In addition to addressing acute issues related to hospitalisation, patients were also able to receive newly translated resources while in clinic.ResultsThe preintervention 30-day-readmission rate was 17.3% (June 2022–December 2022) (95% CI 13.4% to 21.8%). Meanwhile, the postintervention 30-day-readmission rate was 14.7% (June 2023–December 2023) (95% CI 10.9% to 19.2%). While a 2.6% reduction in readmissions was achieved, this decrease was not statistically significant (−2.6%; 95% CI −8.4% to 3.2%; p value=0.375). Emergency use utilisation decreased from 90% to 15%.ConclusionsOur team was able to facilitate and coordinate outpatient care for oncology patients following hospitalisation. The expedited care allowed providers to ensure that the care plan after hospitalisation was well understood and accessible to the patient. Furthermore, language-appropriate resources were provided to patients at that time. Our intervention was feasible, easy to implement and quick to produce tangible improvements in patient care. More time is needed to determine whether this will create a statistically significant impact on readmission rates.
Objective Assessment of the Cardiorespiratory Fitness Among Individuals With Lymphedema and Lipedema: A Systematic Review and Meta‐Analysis
Authors: Vanaki Amirparsa , Fallah Amirhossein , Rahimidanesh Negin , Ashnaei Arian , Naghadian Moghaddam Mohammad Mahdi , Shahrabi Farahani Mohammad , Soltanipur Masood , Yarmohammadi Hossein 
Published: February 2025

Background: One of the main challenges in managing lymphedema and lipedema is the lack of valid and reliable objective measures for diagnosis and follow‐up. This study was aimed at gathering evidence regarding the objective measures of cardiorespiratory fitness (CRF) among these populations.Methods: Scopus, PubMed, and Embase were searched for observational studies investigating the objective measures of CRF among individuals with lipedema and lymphedema. Both primary and secondary lymphedema were included. Different CRF measures reported by the included articles were determined, and the main outcomes regarding these measurements were extracted. The meta‐analysis was performed to compare the pooled mean 6‐min walk test (6MWT) between individuals with lower limb lymphedema and lipedema using STATA software (Version 17.0).Results: Eight articles were included, and the majority of participants were female. Four distinct objective measures of CRF were reported among the included articles, including hemodynamic indices, spirometry indices, VO2 peak, and 6MWT. The mean VO2 peak was significantly lower among women with breast cancer–related lymphedema; however, there was no correlation between affected limb volumes and the VO2 peak. The meta‐analysis revealed a lower mean 6MWT among individuals with lipedema compared to lymphedema (pooled difference: 37.71 [confidence interval (CI): 5.19–70.22], p value: 0.02, I2: 0%). Also, there was a significant relationship between 6MWT and subjective measures of CRF, such as the Short Form 36 (SF‐36) physical function score, in one included article.Conclusion: While limited evidence exists on the objective measures of CRF among individuals with lymphedema and lipedema, there might be a significant difference in 6MWT between these two groups.
Radiological Risk Factors for Osteochondral Fractures in Patients With First-Time and Recurrent Patellar Instability: Data From the JUPITER Cohort
Authors: McGinley James J. , Ellis Henry B. , Propp Bennett , Veerkamp Matthew W. , Wilson Philip L. , Kramer Dennis E. , Heyworth Benton E. , Strickland Sabrina , Wall Eric , Koh Jason , Yen Yi-Meng , Halsey Matthew , Magnussen Robert , Roberts David , Farr Jack , Green Daniel , Fabricant Peter , Brady Jacqueline , Tompkins Marc , Redler Lauren H. , Yanke Adam B. , Sherman Seth L. , Parikh Shital N. , Shubin Stein Beth E. 
Published: February 2025

Background: Radiological risk factors for an osteochondral fracture (OCF) associated with patellar instability are rarely studied, particularly in patients with recurrent instability. Purpose: To identify specific radiological characteristics that relate to the increased prevalence of OCFs associated with patellar instability. Study Design: Case-control study; Level of evidence, 3. Methods: Patient data (n = 730) from the Justifying Patellar Instability Treatment by Early Results (JUPITER) multicenter study were reviewed for radiological findings. Trochlear crossing sign, Caton-Deschamps index (CDI), tibial tubercle–trochlear groove (TT-TG) distance, patellar tilt, trochlear depth, trochlear bump, sulcus angle, and patellar subluxation were measured on radiography or magnetic resonance imaging and classified into 2 categories based on pathological thresholds for general patellar instability. Patients were grouped according to the presence or absence of an OCF and analyzed with the Mann-Whitney test, chi-square test, and multivariate regression. Results: A high CDI was associated with a 0.43 decreased odds of an OCF, while a high TT-TG distance was a risk factor for an OCF, with a 2.17 times increased odds. Although a first-time dislocation increased the odds of an OCF by 4.72 times, recurrent instability was found to have the same predictive relationship of CDI and TT-TG distance with fracture incidence. A lower CDI, a shallower trochlear depth, a smaller trochlear bump, and the presence of a patellar subluxation were more common in patients with OCFs. A lower CDI, positive trochlear crossing sign, and shallower trochlear depth were more common in the subset of patients with recurrent instability and associated OCFs. Conclusion: Patella alta was protective of OCFs in patients with first-time and recurrent instability, while a lateralized tibial tubercle was a risk factor. These radiological characteristics should guide health care professionals on the risk of future OCFs during treatment planning after a patellar instability event.
In Vitro and In Vivo Evaluation of Modulatory Effects of Lutein and Zeaxanthin Supplementation on Retinal Anti-oxidant and Lipofuscin Levels
Authors: Godavarthi Ashok , Seo Seul A. , Park Sang Hyun , Heo Soo-Hyeon , Shivaprasad H.N. 
Published: February 2025

Background Age-related macular degeneration (AMD) is one of the major leading irreversible reasons for severe blindness in the aged population. Oxidative stress is said to be a leading cause of AMD and is very progressive in the major areas of the retina. The anti-oxidant nature of the macular pigments (MPs) and their position in the retina is believed to be responsible for minimizing the effect of AMD. Purpose The aim of this study is to assess the efficacy of Gleamax/VividawnTM containing lutein and zeaxanthin for its protective role against ultraviolet (UV)-induced stress in retinal cells in vitro and evaluating the benefits of eye health by evaluating the cell proliferation, cytoprotection as well as the measurement of lipofuscin (LPF) levels. Methods Human ARPE-19 cell lines were cultured and tested for cytotoxicity with Gleamax/VividawnTM samples. The cytoprotective activity of the Gleamax/VividawnTM was measured by the absorbance value over 72 h in comparison to the absorbance of irradiated and non-irradiated cell control. LPF was estimated using the enzyme-linked immunosorbent assay (ELISA) method, and N-retinylidene- N-retinylethanolamine (A2E) levels were estimated by the Bradford method. In vivo studies in C57BL/6 mice, 14 animals were nurtured with a rich fat diet for 2 weeks to boost obesity, and other animals of the standard control group (G1) received a normal chow diet for 2 weeks. The first group served as a normal control, the second group functioned as a high-fat diet (HFD) control, and the third group was a treatment group that received Gleamax/VividawnTM at 6.2 mg/kg physique weight of the animals per orally daily for consecutive 60 days. Statistical Analysis Used The experimental data were analyzed by one-way analysis of variance (ANOVA) with Dunnett’s test between the treatment and control groups. Results Lutein, with a combination of zeaxanthin supplementation, improves the dysfunction in the central retina, obtaining benefits in terms of visual activity (VA) and glare sensitivity. In this study, standard control (G1) and HFD-fed animals (G2) were observed with below limit of quantification (BLOQ) levels of lutein and zeaxanthin in plasma. However, Gleamax/VividawnTM treated group (G3) animals were found to have significantly elevated levels of lutein and zeaxanthin levels. Conclusion Conclusion: Gleamax/VividawnTM is a unique formula comprising lutein and zeaxanthin, known for its defensive act against oxidative stress; it is also the only dietary carotenoid that can accumulate in the retina, especially in the macula region.
Diagnostic accuracy and radiographic interpretation of pre-eruptive intra-coronal resorption among dental practitioners using eye-tracking technology
Authors: Almashaikhi Jamila , Elkhodary Heba M. , Bhadila Ghalia Y. , Felemban Osama M. , Al Tuwirqi Amani A. 
Published: February 2025

Background Pre-eruptive intra-coronal resorption (PEIR) is a condition in which unerupted teeth exhibit coronal radiolucency consistent with resorptive loss of coronal tooth structure. These lesions are discovered incidentally on routine radiographs. Aim To measure the radiographic interpretation and diagnostic accuracy of PEIR among dental practitioners at King Abdulaziz University Dental Hospital using eye-tracking technology. Methods In this cross-sectional study, 125 interns, general dentists, and postgraduate residents examined five panoramic radiographs, including a case of impaction, and the rest were radiographs with PEIR of different severities. In this study, PEIR recognition was assessed using a validated questionnaire uploaded to an eye-tracking device (Sensomotoric Instruments SMI). Results The findings revealed an association between the severity of the PEIR lesion and the detection of the affected teeth. As the severity increased, the participants were more able to identify the affected teeth, and the percentage of overlooking decreased. The dentist's level of education and years of clinical experience influenced the diagnostic accuracy and radiographic interpretation of the PEIR lesions. Conclusions The diagnostic accuracy and radiographic interpretation of PEIR lesions were affected by participants’ level of education and years of clinical experience. Based on this study, PEIR lesions may remain undetected until they reach advanced stages.
A Novel Indication for 3D-Printed Titanium Total Talus Replacements in Isolated Talar Tumors
Authors: Wismayer Martina Galea , Branford-White Harriet , Davies Mark B. , Brown Rick 
Published: February 2025

Background: Intraosseous talar tumors are rare and usually require complex surgery such as tibiocalcaneal fusion with allograft, resulting in a poor functional outcome. Total talus replacement (TTR) has been primarily described predominantly after trauma for talar avascular necrosis in the absence of peri-talar arthrosis. We present our small initial case series of this novel indication for a TTR to treat a localized talus tumor with no associated osteoarthritis. Methods: Four patients underwent total talus replacement with a custom-made 3D-printed talar implant for an isolated intraosseous talar tumor between February 2021 and December 2022. The pathologies were fibrous dysplasia, a primary vascular tumor, and 2 cases each with an isolated metastatic endometrial carcinoma. All 4 cases were performed by the same surgical team. The Manchester-Oxford Foot Questionnaire (MOXFQ) and EuroQoL–5 Dimensions (EQ-5D) questionnaire were recorded pre- and postoperatively. Results: At a mean follow-up of 26 months (range, 14-37) all our patients showed an improvement in their MOXFQ and EQ-5D scores. Average MOXFQ scores decreased from 57.3 to 20.3. Three of the 4 patients showed an improvement in their function and ability to perform usual activities. One patient scored an improvement in their mobility. None had any intraoperative or postoperative complications. Conclusion: TTR is an alternative technique for the management of isolated talar tumors, which will maintain movement and provide better function than previous options.
Machine learning prediction of erosion resistance of laser-clad coatings on martensitic stainless steel for steam turbine blades
Authors: Mandal Indranil , Kumar Vidyapati , Saha Partha 
Published: February 2025

Steam turbine blades made of martensitic stainless steel (SS 420) are susceptible to erosion due to the impact from the water droplets. Laser-directed energy deposition (L-DED) process can enhance erosion resistance of steam turbine blades by laser-clad protective coatings, but the process intricacies arising from multiple parameters require some predictive modelling. This study developed machine learning models to predict surface roughness (SR), cumulative mean depth of erosion (CMDE) and hardness of SS 420 substrates coated by L-DED process with Ni-Al, Ni-Al-TiC and Stellite 6 powders. The input parameters were laser power, scanning speed, powder flow rate, energy density, time, initial temperature, feeding rate and distance from the surface. Seven algorithms, namely, Linear Regression, Decision Tree, Random Forest, Gradient Boosting (GB), K-Nearest Neighbours, AdaBoost and XGBoost, were trained on the experimental data. Cross-validation assessed the model accuracy. XGBoost model showed the lowest mean absolute error and the highest R 2 for predicting SR. GB was the most accurate for CMDE and hardness. By demonstrating accurate prediction of the properties of L-DED coating using machine learning, this study provides a framework to optimize the L-DED process for enhanced erosion resistance of steam turbine blades. Further research can assess model performance for new parameter combinations and materials.
Association of fibrotic-related extracellular vesicle microRNAs with lung involvement in systemic sclerosis
Authors: Guiot Julien , André Béatrice , Potjewijd Judith , Jacquerie Pierre , Cremers Sébastien , Henket Monique , Idoufkir Latifa , Remacle Claire , Tobal Rachid , Giltay Laurie , Moermans Catherine , Gester Fanny , Polese Barbara , Hamaïdia Malik , Struman Ingrid , Louis Edouard , Malaise Michel , de Seny Dominique , van Paassen Pieter , Louis Renaud , Ribbens Clio , Njock Makon-Sébastien 
Published: February 2025

BackgroundThere is a pressing need to identify early biomarkers of lung involvement in systemic sclerosis (SSc) to start as soon as possible antifibrotic therapy. We aimed to identify extracellular vesicle-derived microRNAs (EV-miRNAs) that are differentially expressed between SSc patients with and without interstitial lung disease (ILD), explore their diagnostic value and investigate their functional properties.MethodsSmall EVs (sEVs) derived from plasma were isolated from 91 well-characterised SSc patients with ILD (SSc-ILD, n=45), without ILD (SSc-no ILD, n=46) and 43 matched healthy subjects (HS). Small RNA sequencing followed by quantitative RT-PCR were used to identify and validate sEV-miRNAs associated to SSc-ILD. Correlations between SSc-ILD-associated miRNAs and clinical parameters were assessed, as well as the impact of related miRNAs/sEVs on fibrosis.ResultsWe identified a 4-miRNA signature associated with ILD in SSc context (miR-584-5p, miR-744-5p, miR-1307-3p and miR-10b-5p) (ROC AUC=0.85, 95% CI 0.76–0.94, p<0.0001). Deeper analysis revealed a correlation of these candidates with pulmonary function tests (DLCO and FVC), highlighting their capacity to monitor lung fibrosis progression in SSc patients. Furthermore, SSc-ILD-associated sEV miRNAs are positively correlated and enriched in circulating lymphocytes, suggesting that these immune cells are their cellular source. Finally, functional studies highlighted an alteration of functional properties of sEVs in SSc-ILD context mainly due to the transfer of profibrotic miR-584–5p in lung fibroblasts.ConclusionsOur sEV-based biomarker approach enabled to identify a promising 4-miRNA signature characteristic of ILD in SSc patients. Furthermore, the profibrotic properties of SSc-ILD-associated sEVs suggest a prominent role of these vesicles on SSc severity.
A stakeholder-driven approach to designing a peer recovery coach role for implementation in community-oriented primary care teams in South Africa
Authors: Myers Bronwyn , Regenauer Kristen S. , Johnson Kim , Brown Imani , Rose Alexandra L. , Ciya Nonceba , Ndamase Sibabalwe , Jacobs Yuche , Anvari Morgan S. , Hines Abigail , Dean Dwayne , Baskar Rithika , Magidson Jessica F. 
Published: February 2025

Abstract

Introduction
In South Africa, community-oriented primary care teams work to re-engage out-of-care people with HIV (PWH) in treatment, many of whom have substance use (SU) concerns. SU stigma is high among these teams, limiting care engagement efforts. Integrating peer recovery coaches into community-oriented primary care teams could shift SU stigma and improve patients’ engagement in care. The peer role does not exist in SA and represents a workforce innovation. To enhance acceptability, feasibility, and appropriateness for the local context, we engaged multiple stakeholder groups to co-design a peer role for community-oriented primary care team integration.

Methods
We used a five-step human-centered design process: (i) semi-structured interviews with healthcare worker (n = 25) and patient (n = 15) stakeholders to identify priorities for the role; (ii) development of an initial role overview; (iii) six ideation workshops with healthcare worker (n = 12) and patient (n = 12) stakeholders to adapt this overview; (iv) refinement of the role prototype via four co-design workshops with healthcare worker (n = 7) and patient (n = 9) stakeholders; and (v) consultation with HIV and SU service leaders to assess the acceptability and feasibility of integrating this prototype into community-oriented primary care teams.

Results
Although all stakeholders viewed the peer role as acceptable, patients and healthcare worker identified different priorities. Patients prioritized the care experience through sharing of lived experience and confidential SU support. Healthcare worker prioritized clarification of the peer role, working conditions, and processes to limit any impact on the community-oriented primary care team. A personal history of SU, minimum 1 year in SU recovery, and strong community knowledge were considered role prerequisites by all stakeholders. Through the iterative process, stakeholders clarified their preferences for peer session structure, location, and content and expanded proposed components of peer training to include therapeutic and professional work practice competencies. Service leaders endorsed the prototype after the addition of peer integration training for community-oriented primary care teams and peer mentoring to address community and team dynamics.

Conclusion
Stakeholder engagement in an iterative design process has been integral to co-designing a peer role that multiple stakeholder groups consider acceptable and that community-oriented primary care teams are willing to implement. This offers a methodological framework for other teams designing SU workforce innovations.