bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relying on Runaways
Authors: Kaelin Kelly 
Published: April 2024

Abstract
In her 1772 memoir, Sarah Chapman relays an exciting tale of daring escape from her parent’s home in December 1752. She was seventeen, single, and determined to join the Moravian Church, a new group originating in eastern Saxony. Women like Sarah—usually young and single—saw in the Moravians an alternative to settled life. This article explores the place of the Moravian Church as a disruptive organization which built congregations of young people who separated themselves from home and family, often dramatically retold in spiritual memoirs. Their Hussite proto-Reformation influences, combined with the charismatic leadership of the Saxon Count Zinzendorf, provided space for diverse forms of female participation. Through tales of run-away women, I argue that studying Moravian women disrupts the traditional conception of church creation as predominantly male and instead reconceives the religious fracturing of eighteenth-century Protestantism as something intimately experienced by women, even those young and single.
Responding to the COVID-19 Care Home Crisis
Authors: Ó Fathaigh Cillian 
Published: April 2024

Abstract
This article attends to Beauvoir’s concept of the image in The Coming of Age, Les Belles Images, and A Walk through the Land of Old Age. The author argues that the experience of being an older adult emerges primarily from the available social images of old age rather than from the aging body. This view reveals problems with the discourse around older people that fueled the COVID-19 care home crisis and that persist in our response to the crisis.
Self-Translation and Comics: Practices, Attitudes, and Publishing
Authors: Van Dijk Floriane 
Published: April 2024

Abstract
This article is the first attempt to identify comics self-translators and analyze their practices, taking into account the multimodality of the medium. Based on this corpus of comics authors who have translated their own work, this article addresses the contexts (sedentary or migratory) in which they work, the languages they use, and the way they publish their works. It discusses the attitudes that comics self-translators have toward self-translation, especially in terms of their own perceived freedom, before analyzing the authors’ translation choices, while considering how authors collaborate with other parties, including the illustrators. Finally, attention is paid to the publishing choices, including avenues, timelines, and editing choices related to the comic book covers. These reflections open a new topic of research around the specificities of self-translated comics and of comics self-translators themselves.
Nonnormative Self-Translation and Code-Switching in Argentina ’s New Feminist and Queer Poetry
Authors: Stocco Melisa 
Published: April 2024

Abstract
This article examines the poetry of feminist writer Dolo Trenzadora (b. 1985, Buenos Aires) and queer author Franco Rivero (b. 1981, Corrientes), two new voices in Argentine poetry who write in both Spanish and Guarani and reflect multilingual experiences emerging against the backdrop of a monolingual imaginary of nationhood. The analysis seeks to identify, within these writers’ most recent works, particular forms of “fragmentary intratextual self-translation” and to observe how, along with code-switching, these expressions of self-translation: (1) develop a nonnormative heterolingual discourse that defies monolingualism and troubles notions of national, gender, and sexual identity; and (2) resist monolingual models of Translation Studies.
In the Vanguard of the 1930s Reformed Resurgence
Authors: Stewart Kenneth J. 
Published: April 2024

Abstract
The first two decades of the twenty-first century have manifested a large-scale revival of interest in John Calvin, Reformed Theology and popular forms of Calvinism. Journalists have scrambled to grasp the parentage of a movement which had so long been out of the public view. Sympathetic Christian writers have developed a range of hypotheses about the roots of this resurgence, with most concentrating on developments unfolding since the mid-twentieth century. This essay maintains that the actual roots of the contemporary Calvinist resurgence lie in the period following the Great War (1914–1918), when three distinguishable streams of Protestant thought found common ground and for a period of at least a quarter-century collaborated to draw attention to the resources offered in the broadly Reformed theological tradition.
Efficacy of fat quantification methods used in MRI to distinguish between normal, benign, and malignant bone marrow pathologies in children
Authors: Erkal Tonkaz Duygu , Ozpar Rifat , Tonkaz Mehmet , Yazici Zeynep 
Published: April 2024

Background Fat quantification methods in magnetic resonance imaging (MRI) have been studied to differentiate bone marrow pathologies in adult patients; however, scarce literature is available in pediatric patients. Purpose To evaluate the efficacy of the T1 signal intensity value (T1-SIV), out-of-phase/in-phase signal ratio (OP/IP SR), and fat fraction (FF) to differentiate between normal, benign, and malignant pathological processes. Material and Methods A total of 48 pediatric patients with lumbar and pelvic MRI were classified into three groups according to bone marrow pathology (group 1, normal; group 2, benign pathology/reconversion; group 3, malignant). The efficacy of T1-SIV, OP/IP SR, and FF values in differentiating these pathologies was evaluated using Kruskal–Wallis or analysis of variance and followed by Bonferroni or Dunn–Bonferroni tests. Cutoff values for malignant infiltration were defined using ROC analysis. Results Although these values were significantly different in all three groups ( P = 0.001–0.008), this difference was not sufficient to discriminate between all groups. Subgroup analyses showed significant differences in T1-SIV between groups 1–3, in OP/IP SR between groups 1–3, 2–3, and 1–2, in FF between groups 1–2 and 1–3 in various regions ( P = 0.001–0.049). Cutoff values had a sensitivity and specificity of 90%–100% for OP/IP SR and FF. Conclusion T1-SIV, OP/IP SR, and FF may potentially distinguish normal from pathological bone marrow. OP/IP SR and FF values detected malignant infiltration with high sensitivity and specificity in this study. However, only OP/IP SR may significantly differentiate benign and malignant bone marrow pathologies which needs to be confirmed in the future study with a larger patient population.
Aqueous Extract of Pinellia ternata Breitenbach Tuber Ameliorates Bilateral Common Carotid Artery Stenosis-Induced Cognitive Deficit in Mice by Suppressing the Activation of Astrocytes
Authors: Kim Kyong-Lim , Lim Chiyeon , Lim Sehyun , Cho Suin , Kim Kyung-Min 
Published: April 2024

Background The proportion of dementia patients in Asian countries is rapidly increasing, and because vascular dementia is more common than in the West, it is recognized as important as Alzheimer’s disease. Purpose The aim of this study was to verify the benefits of Pinellia ternata Breitenbach tuber aqueous extract (PTex) in improving cognitive function and reducing inflammation in brain damage resulting from bilateral common carotid artery stenosis (BCAS). Materials and Methods Four groups of five C57BL/6 male mice each were randomly assigned (a sham group, a BCAS surgery group, and two experimental groups that received PTex concentrations of 25 and 50 mL/kg, respectively). Measuring behavioral learning and memory, the two concentrations of the extract were given orally three times a week for six weeks following BCAS surgery. Furthermore, the inflammatory response in the cerebral cortex was observed, and RNA sequencing analysis was carried out. Results The novel object recognition test revealed that the PTex-50-treated group had improved cognitive function, and the anti-inflammatory effect was confirmed by immunofluorescence staining of brain tissue. Proteins such as Apob, Shh, Dscc1, Cdc45, and Cdc6 were identified through protein-protein interaction network analysis as having a beneficial effect on BCAS-induced cognitive deficit. Conclusion Results show that PTex-50 was found to have a beneficial effect on BCAS-induced cognitive deficit.
Montelukast as a repurposable additive drug for standard-efficacy multiple sclerosis treatment: Emulating clinical trials with retrospective administrative health claims data
Authors: Manuel Astrid M , Gottlieb Assaf , Freeman Leorah , Zhao Zhongming 
Published: April 2024

Background: Effective and safe treatment options for multiple sclerosis (MS) are still needed. Montelukast, a leukotriene receptor antagonist (LTRA) currently indicated for asthma or allergic rhinitis, may provide an additional therapeutic approach. Objective: The study aimed to evaluate the effects of montelukast on the relapses of people with MS (pwMS). Methods: In this retrospective case–control study, two independent longitudinal claims datasets were used to emulate randomized clinical trials (RCTs). We identified pwMS aged 18–65 years, on MS disease-modifying therapies concomitantly, in de-identified claims from Optum’s Clinformatics® Data Mart (CDM) and IQVIA PharMetrics® Plus for Academics. Cases included 483 pwMS on montelukast and with medication adherence in CDM and 208 in PharMetrics Plus for Academics. We randomly sampled controls from 35,330 pwMS without montelukast prescriptions in CDM and 10,128 in PharMetrics Plus for Academics. Relapses were measured over a 2-year period through inpatient hospitalization and corticosteroid claims. A doubly robust causal inference model estimated the effects of montelukast, adjusting for confounders and censored patients. Results: pwMS treated with montelukast demonstrated a statistically significant 23.6% reduction in relapses compared to non-users in 67.3% of emulated RCTs. Conclusion: Real-world evidence suggested that montelukast reduces MS relapses, warranting future clinical trials and further research on LTRAs’ potential mechanism in MS.
Agreement of synchronous remote and in-person application of the Alberta Infant Motor Scale: Cohort study
Authors: Passamani Rafaela S , Shigihara Carolina K , Gomes Paula G , dos Santos Adriana N 
Published: April 2024

Introduction Using standardized scales to assess motor development via telemedicine can increase access for low-income populations. Our aim was to verify the agreement and feasibility between remotely and synchronously applying the Alberta Infant Motor Scale (AIMS) and the in-person format. Methods This was a concordance study, with 77 typical infants aged 4–18 months (mean = 13 months). The AIMS was applied remote via video calls and face-to-face. We applied a questionnaire to caregivers to verify feasibility. Results There was a high level of agreement between the remote and in-person assessments, with intraclass correlation coefficients above 0.98 and low standard error measure values (<1 item for each posture, <2 items for the total raw score, and =5% for the normative score). The smallest detectable change was between 1.67 and 2.45 for each posture, 3 for the total raw score, and 6% for the normative score. The Bland–Altman analysis showed low bias with the mean difference close to zero (<0.80) and low error with little dispersion of the difference points around the mean. Caregivers’ perspectives on the synchronous remote assessment were positive, with good quality, clear information during the assessment, and comfort with the method. Discussion The synchronous remote application of the AIMS may be an alternative for families without access to in-person services that assess motor development.
In-stent restenosis estimation following carotid artery stenting: The robust predictive value of atherogenic index of plasma and other non-traditional lipid profiles
Authors: Yılmaz Cemalettin , Güvendi Şengör Büşra , Zehir Regayip , Kaya Ahmet Ferhat , Özdil Mehmet Hasan , Karaduman Ahmet , Kültürsay Barkın 
Published: April 2024

Objective Atherosclerotic carotid artery stenosis is a significant contributor to ischemic strokes, and carotid artery stenting (CAS) has emerged as a pivotal treatment option. However, in-stent restenosis (ISR) remains a concern, impacting the long-term patency of CAS. This study aimed to investigate the predictive value of non-traditional lipid profiles, including the atherogenic index of plasma (AIP), in ISR development. Methods This retrospective single-center study involved patients presenting at a tertiary healthcare facility with severe carotid artery disease between 2016 and 2020 who subsequently underwent CAS. A total of 719 patients were included in the study. The study cohort was divided into ISR and non-ISR groups based on restenosis presence, confirmed by angiography following ultrasonographic follow-up assessments. Non-traditional lipid indices, such as AIP, atherogenic index (AI), and lipoprotein combined index (LCI), were evaluated along with traditional risk factors. Results During a 24-month follow-up, ISR occurred in 4.03% of patients. To determine the predictors of restenosis, three different models were constructed in multivariate analysis for non-traditional lipid indices. Multivariate analysis revealed AIP as a robust independent predictor of ISR (OR: 4.83 (CI 95 % 3.05–6.63, p < .001). Notably, AIP demonstrated superior predictive accuracy compared to AI and LCI, with a higher Area Under the Curve (AUC) of 0.971. Conclusion Non-traditional lipid profiles, especially AIP, were found to be associated with an increased risk of ISR and may serve as predictors of ISR in patients undergoing CAS.
Radiofrequency ablation for the treatment of great saphenous venous insufficiency using a newly developed VENISTAR catheter: A preliminary study
Authors: Min Jeeyoung , Hwang Jin Ho , Park Sang Woo , Hwang Jae Joon , Kim Jun Seok , Lee Song Am , Chee Hyun Keun 
Published: April 2024

Objectives This study was aimed to assess the preliminary outcomes of radiofrequency ablation (RFA) using a newly developed catheter (VENISTAR) for the treatment of incompetent great saphenous veins (GSVs). Methods In this prospective observational study, endovenous RFA using a VENISTAR catheter was performed on 16 saphenous veins in 12 patients between August and November 2019. Patients’ pre- and post-procedural data were recorded. Doppler ultrasound imaging and clinical evaluation were performed at 1 week and 1, 3, and 6 months to determine the efficacy and safety of the treatment. Results Technical success and complete closure of the targeted GSVs immediately after the procedure were observed in all 16 limbs (100%). However, one patient (one limb) was found to have partial occlusion without significant reflux after 1 week of follow-up. Kaplan–Meier analysis yielded a complete occlusion rate of 93% at 6 months of follow-up. The Venous Clinical Severity Scores at the time of all follow-up were significantly lower than those at baseline (3.3 ± 1.1 at baseline to 0.6 ± 0.6, 0.3 ± 0.6, 0.1 ± 0.4, and 0.2 ± 0.4 at 1 week and 1, 3, and 6 months, respectively) ( p < .001). Mild post-procedural pain was noted in 7 and 4 limbs at 1 week and 1 month, respectively. Grade 1 ecchymosis over the ablated segment was noted in 5 (35.7%) of 14 limbs at 1-week follow-up. Conclusions Endovenous treatment of GSV insufficiency using a new VENISTAR radiofrequency catheter has been shown to be feasible, effective, and safe throughout the 6-month follow-up.
Body Mass Index, Sex, and Age Are Predictors of Discharge to a Post-acute Care Facility Following Total Ankle Arthroplasty
Authors: Bakaes Yianni , Gonzalez Tyler , Hardin James W. , Jackson J. Benjamin 
Published: April 2024

Background The utilization of total ankle arthroplasty (TAA) continues to increase. Discharge to a post-acute care (PAC) facility can increase patient morbidity and postoperative costs. The purpose of this study is to investigate the effects of age and body mass index (BMI) on discharge to a PAC facility and hospital length of stay (LOS) following TAA. Methods A retrospective review of patients who underwent TAA from the National Surgical Quality Improvement Program (NSQIP) database was performed. Using overweight patients as the reference BMI group, sex- and age-adjusted log-binomial regression models were utilized to estimate risk ratios of BMI categories for being discharged to a PAC facility. A linear regression was utilized to estimate the effect of BMI category on hospital LOS. Results Obese patients had 1.36 times the risk of overweight patients (P = .040), and morbidly obese patients had 2 times risk of overweight patients (P = .001) of being discharged to a PAC facility after TAA. Men had 0.48 times the risk of women (P < .001). Compared with patients aged 18 to 44 years, patients aged ≥65 years had 4.13 times the risk (P = .012) of being discharged to a PAC facility after TAA. Relative to overweight patients, on average there was no difference in hospital LOS for underweight patients, but healthy weight patients stayed an additional 0.30 days (P=.003), obese patients stayed an additional 0.18 days (P = .011), and morbidly obese patients stayed an additional 0.33 days (P = .009). Men stayed 0.29 fewer hospital days than women (P < .001) on average. Conclusion Women and patients who are obese or morbidly obese have a longer hospital LOS and an increased chance of being discharged to a PAC facility. Increasing age is also associated with an increased risk of being discharged to a PAC. These may be important factors when developing and discussing the postoperative plan with patients prior to TAA. Levels of Evidence: Level III
Endoscopic Dacryocystorhinostomy Following Nasolacrimal Drainage System Trauma and Medial Orbital Wall Reconstruction
Authors: Turner Laura Drayer , Gounder Pav A. , Dobson Randolph , Rajak Saul N. 
Published: April 2024

Study Design Case series. Objective To describe the assessment and surgical approach to dacryocystorhinostomy (DCR) for patients with nasolacrimal duct obstruction (NLDO) in the presence of orbital wall hardware. Methods The pre-operative assessment, management and outcomes of two patients with secondary acquired NLDO following medial orbital wall fracture repair treated by nasal endoscopic DCR. Results Anatomical and functional success was achieved in both cases at 6 weeks post operatively without disruption of the orbital plate. There was persistent success at 1 and 3 years’ post-operatively. Conclusions Endoscopic DCR is a good option for the treatment of NLDO in patients with previous medial orbital wall fracture repair where the location of the plate may complicate the external approach.
The Functional Integrity of the Anterior Cruciate Ligament Can Be Objectively Assessed With the Use of Stress Radiographs: A Systematic Review
Authors: Schwartz Jake , Rodriguez Ariel N. , Banovetz Mark T. , Braaten Jacob A. , Larson Christopher M. , Wulf Corey A. , Kennedy Nicholas I. , LaPrade Robert F. 
Published: April 2024

Background: Stress radiography is a viable imaging modality that can also be used to assess the integrity of the anterior cruciate ligament (ACL) after primary or secondary injury. Because conventional radiography is relatively easy, affordable, and available worldwide, the diagnostic efficacy of ACL standing, lateral decubitus, and supine stress radiography should be evaluated. Purpose: To examine the existing literature regarding the application of stress radiography in evaluating the integrity of the ACL. Study Design: Systematic review; Level of evidence, 3. Methods: Using the PubMed and MEDLINE databases for relevant articles published between 1980 and the present, a systematic review was conducted to identify evidence related to the radiographic diagnosis or assessment of ACL tears. The literature search was conducted in September 2022. Results: Of 495 studies, 16 (1823 patients) were included. Four studies examined standing stress radiography, and 12 investigated lateral decubitus or supine stress radiography. Significant heterogeneity in imaging technique and recorded anterior tibial translation was identified. Anterior tibial translation for ACL-injured knees ranged from 1.2 to 10.6 mm for standing stress radiographs and 2.7 to 11.2 mm for supine stress radiographs, with high sensitivities and specificities for both. Conclusion: Stress radiography was a dependable diagnostic method for identifying ACL rupture. Further research is necessary to determine the ideal anatomic landmarks, optimal patient positioning, and appropriate applied stresses to establish a standardized protocol for both assessing ACL tears and evaluating the postoperative integrity of ACL reconstruction using stress radiography.
Clinical implications of innate immune exhaustion in cystic fibrosis
Authors: Møller Rikke , Uhre Nielsen Bibi , Rossi Elio , Lausen Mads , Skov Marianne , Pressler Tacjana , Ostrowski Sisse Rye , Johansen Helle Krogh 
Published: April 2024

ObjectivesLung disease progression in people with cystic fibrosis (pwCF) varies from one individual to another. Different immunological characteristics have been suggested to explain this variation, and we hypothesised that lung capacity may be associated with the innate immune response in pwCF. In an exploratory study, we aimed to investigate potential links between the innate immune response and lung function in pwCF using the standardised immune function assay TruCulture.MethodsIn a single-centre study with combined cross-sectional and longitudinal data before and after intravenous antibiotics, blood was sampled fromPseudomonas aeruginosa-infected pwCF. Whole blood was analysed by TruCulture to reveal the unstimulated and stimulated cytokine release. Tobit regressions and Spearman's correlations were used to estimate the associations between lung function and cytokine release.ResultsWe included 52 pwCF in the cross-sectional study and 24 in the longitudinal study. In the cross-sectional study, we found that compared to a healthy population, the release of toll-like receptor (TLR)3, TLR4- and TLR7/8-stimulated interferon-γ, and interleukin (IL)-12p40 was reduced. Although TLR3-stimulated IL-1β and IL-6 release increased with lung function, overall, cytokine release did not correlate well with lung function. In the longitudinal study, the cytokine release was modified by antibiotic treatment, but the cytokine release before antibiotic treatment did not associate with changes in lung function after treatment.ConclusionThe stimulated cytokine release could not predict lung function levels or changes in pwCF, but our data indicate that pwCF experience exhaustion in the innate immune response after years of chronic bacterial infection.