bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes from hematopoietic stem cell transplantation following treosulfan‐based conditioning: A clinical and pharmacokinetic analysis
Authors: Rosser Sebastian P. A. , Brewer Alice , Gabriel Melissa , Wong Melanie , Chung Jason , McLachlan Andrew J. , Nath Christa E. , Keogh Steven J. , Shaw Peter J. 
Published: May 2024

AbstractBackgroundThe aims of this study are to report our experience with treosulfan‐based conditioning regimens for patients with non‐malignant hematologic conditions, correlating clinical outcomes at different time points post‐transplant with treosulfan exposure (AUC).MethodsThis study was a single‐center observational study investigating overall survival (OS), disease‐free survival (DFS), and event‐free survival (EFS) end‐points post‐transplant. The consequences of treosulfan AUC with respect to toxicity, correction of underlying disease, and long‐term chimerism were also explored using pharmacokinetic analysis.ResultsForty‐six patients received 49 transplants with treosulfan and fludarabine‐based conditioning between 2005 and 2023. Twenty‐four patients also received thiotepa. Donor chimerism was assessed on either whole blood or sorted cell lines at different time points post‐transplant. Thirty‐nine patients received treosulfan pharmacokinetic assessment to evaluate cumulative AUC, with five infants receiving real‐time assessment to facilitate daily dose adjustment. OS, DFS, and EFS were 87%, 81%, and 69%, respectively. Median follow‐up was 32.1 months (range 0.82–160 months) following transplant. Lower EFS was associated with patient age (<1 year; p = .057) and lower cumulative treosulfan dose (<42 g/m2; p = .003). Stable donor chimerism in B‐cell, NK‐cell, and granulocyte lineages at 1‐year post‐transplant were more prevalent in patients receiving thiotepa conditioning. Two infants required daily dose adjustment to treosulfan to avoid high AUC.ConclusionsExcellent clinical outcomes and stable chimerism were observed in this patient series. The addition of thiotepa conferred no significant toxicity and trended toward sustained ongoing donor engraftment. Correlating treosulfan AUC with long‐term patient outcomes is required.
The response readiness tool: An instrument to measure knowledge, skills, and attitude after taking a stop the Bleed® course
Authors: Johnston Katheryn Courville , Deal Belinda , Estrada Samantha , Elizabeth Caulkins , Barnes Glenn , Swanberg Amanda 
Published: May 2024

AbstractStop the Bleed® is an emergency response course that offers a certificate of completion but no ending assessment. The purpose of this educational study was to develop and test the Response Readiness Tool (RRT) that measures learning of participants after taking Stop the Bleed®. The study used a pre‐/post‐test design to measure knowledge and attitudes, and a post‐test only for skills. Participants were recruited from existing Stop the Bleed® courses. Knowledge was measured with a 10‐item questionnaire, attitude was measured with five Likert‐style questions, and skills were measured by observing simulated tourniquet placement. Ninety‐five participants were recruited over two semesters. There was a significant difference in the knowledge and attitude scores indicating participants’ improvement in learning and attitude toward responding. Internal consistency reliability of scores showed moderate reliability with Cronbach's Alpha of 0.73 and McDonald's Omega of 0.75. A positive correlation was found between expected proficiency and pre‐test indicating the tool had construct validity. RRT provides Stop the Bleed® instructors with an instrument to measure knowledge, skills, and attitude of participants after taking Stop the Bleed®. Statistics show moderate reliability and validity; however, larger samples are needed for full psychometric testing. This publication presents the revised tool after the completion of this study.
Interleukin 17F Gene Polymorphism as a Potential Protective Factor in the Immunopathology of Ocular Toxoplasmosis
Authors: da Silva Danilo Donizete , Frederico Fábio Batista , Previato Mariana , Siqueira Rubens Camargo , Bonini‐Domingos Claudia Regina , de Souza Victor Hugo , Castiglioni Lilian , Brandão Cinara Cássia , de Mattos Luiz Carlos , Ayo Christiane Maria 
Published: May 2024

ABSTRACTOcular toxoplasmosis (OT) is characterised by intraocular inflammation due to Toxoplasma gondii infection. Studies have found that interleukin 17 (IL‐17) plays a central role in the pathology of OT. However, nucleotide variability in IL17 and interleukin 17 receptor (IL17R) genes has not been characterised in OT. As cytokine gene polymorphisms may influence the expression of these molecules, the aim of this study was to verify whether IL17A (rs2275913), IL17F (rs763780), IL17RA (rs4819554) and IL17RC (rs708567) polymorphisms are associated with OT in a Brazilian population. This study enrolled 214 patients seropositive for T. gondii (110 with OT and 104 without) and 107 controls. Polymorphisms were identified by PCR‐restriction fragment length polymorphism analysis, validated by DNA sequencing with chi‐square and multivariate analyses being used to assess possible associations between polymorphisms and OT. Logistic regression under the dominant model revealed a protection factor against OT of the C mutant allele of the IL17F (rs763780) polymorphism. The T/C‐C/C genotypes were significantly more common in patients without OT compared to those with OT (p value = 0.0066) and controls (p value = 0.014). Findings from this study suggest that the IL17F polymorphism may have an influence in the immunopathology of OT in Brazilian individuals.
Metabolic changes in tomato plants caused by psychrotolerant Antarctic endophytic bacteria might be implicated in cold stress mitigation
Authors: Licciardello Giorgio , Doppler Maria , Sicher Carmela , Bueschl Christoph , Ruso David , Schuhmacher Rainer , Perazzolli Michele 
Published: May 2024

AbstractClimate change is responsible for mild winters and warm springs that can induce premature plant development, increasing the risk of exposure to cold stress with a severe reduction in plant growth. Tomato plants are sensitive to cold stress and beneficial microorganisms can increase their tolerance. However, scarce information is available on mechanisms stimulated by bacterial endophytes in tomato plants against cold stress. This study aimed to clarify metabolic changes stimulated by psychrotolerant endophytic bacteria in tomato plants exposed to cold stress and annotate compounds possibly associated with cold stress mitigation. Tomato seeds were inoculated with two bacterial endophytes isolated from Antarctic Colobanthus quitensis plants (Ewingella sp. S1.OA.A_B6 and Pseudomonas sp. S2.OTC.A_B10) or with Paraburkholderia phytofirmans PsJN, while mock‐inoculated seeds were used as control. The metabolic composition of tomato plants was analyzed immediately after cold stress exposure (4°C for seven days) or after two and four days of recovery at 25°C. Under cold stress, the content of malondialdehyde, phenylalanine, ferulic acid, and p‐coumaric acid was lower in bacterium‐inoculated compared to mock‐inoculated plants, indicating a reduction of lipid peroxidation and the stimulation of phenolic compound metabolism. The content of two phenolic compounds, five putative phenylalanine‐derived dipeptides, and three further phenylalanine‐derived compounds was higher in bacterium‐inoculated compared to mock‐inoculated samples under cold stress. Thus, psychrotolerant endophytic bacteria can reprogram polyphenol metabolism and stimulate the accumulation of secondary metabolites, like 4‐hydroxybenzoic and salicylic acid, which are presumably involved in cold stress mitigation, and phenylalanine‐derived dipeptides possibly involved in plant stress responses.
Presidential attentiveness to international crises
Authors: Snyder Neil 
Published: May 2024

AbstractWhy, and under what conditions, do international crises make the president's national security agenda? I argue that international crises are opportunities for presidents to seek domestic political gains, but that presidents are likely to weigh anticipated political benefits against anticipated risk of political opposition. I analyze presidential National Security Council (NSC) meeting agendas from 1947 to 1993 to find that the War Powers Resolution (WPR) of 1973 reduced the likelihood of presidential crisis attentiveness, that low approval ratings are associated with increased crisis attentiveness, and that post‐WPR presidents under unified government are likely to be more crisis attentive. This article provides fresh analysis of the WPR by connecting presidential national security behavior with American domestic politics.
Metabolic Modernities: Digestion, Energy Transformations, and the Making and Unmaking of the World in Early Soviet Literature
Authors: Fratto Elena 
Published: May 2024

AbstractEarly Soviet society featured clear nutrition guidelines and a robust plan for streamlined logistics in food processing, distribution, and consumption, all of which was aimed at building a stronger state through a virtuous transformation of calories into labor power. Such rhetoric appeared even in children’s illustrated books, such as Vladimir Maiakovskii and Nikolai Kupreianov’s Story of Petia, Fat Boy, and of Sima, Who is Skinny (1926). This paper shows how in the 1920s authors such as Viktor Shklovskii and Iurii Olesha turned that rhetoric on its head and pushed back against the early Soviet obsession with planning and mastering nature and the human body by employing metaphors of food, digestion, and agriculture. In Shklovskii’s memoirs A Sentimental Journey (1923) and Knight’s Move (1923) and Olesha’s novel Envy (1927), the October Revolution itself emerges as a metabolic process on a vast scale: prerevolutionary aesthetic threads, motifs, and concepts are broken down and processed, reassembled, and repurposed into a seemingly new society and worldview, in which the individual original components are still recognizable.
Considering sociocultural contexts of racism in psychological research on black forgiveness
Authors: Perez Michael J. , Rivera Grace N. , Crist Jaren D. , Garcia Alejandro A. 
Published: May 2024

AbstractIn this paper, we argue that a cultural context of racism in the United States influences the representation and outcomes of Black forgiveness. Previous research in psychology has focused on the positive social and emotional benefits of forgiveness; however, the consequences of Black forgiveness are not always straightforward. We review prior research and highlight real‐world examples that suggest Black people are often pressured and expected to forgive racism. This pressure to forgive overshadows calls for justice and encourages forgiveness as a more palatable, less antagonistic response to racism. Furthermore, we argue that this expectation suppresses Black emotions by stigmatizing negative emotional reactions to racism in favor of forgiveness. We conclude by proposing future lines of research in social psychology that do not reinforce a pressure for Black forgiveness, that foster a study of forgiveness that incorporates social justice, and that considers new lines of forgiveness research that are culturally sensitive to Black experiences.
Internalizing the model minority myth: Dangers for Asian American mental health and attitudes towards other minorities
Authors: Rajagopal Shreya K. , Durkee Myles I. 
Published: May 2024

AbstractThe model minority myth (MMM) falsely portrays Asian Americans as the “model minority” racial group in the United States due to their perceived educational and professional success. The MMM also paints an overly positive picture of the Asian American experience by ascribing primarily positive racial stereotypes to this group and blatantly disregarding the social adversity they continue to face as a racially marginalized population in the U.S. Research has demonstrated that even positive racial stereotypes can cause psychological harm due to heightened pressure to achieve unrealistic expectations. However, less is known about the psychological process of how Asian Americans internalize the stereotypes associated with the MMM. This article seeks to fill this gap by providing a review of the existing research regarding the internalization of the MMM among Asian Americans. Further, this article contributes to the literature by specifying how MMM internalization (a) impacts the way that Asian Americans view themselves, (b) influences mental health outcomes among Asian Americans, and (c) impacts the attitudes that Asian Americans form about other racial minority groups in the U.S. This article highlights several key gaps in the existing literature that should be addressed in future research and provides strategic policy recommendations for practitioners who seek to reduce psychological consequences resulting from internalizing stereotypes that portray Asian Americans as a “model minority”.
Characteristics and significance of programmed cell death‐related gene expression signature in skin cutaneous melanoma
Authors: Wu Xiaoxia , Chen Suhong , Ji Qingfa , Chen Han , Chen Xiuxia 
Published: May 2024

AbstractBackgroundProgrammed cell death (PCD) pathways play crucial roles in the pathogenesis of skin cutaneous melanoma (SKCM). Understanding their prognostic significance and clinical implications is imperative for the development of personalized treatment strategies.MethodsA total of 1466 PCD‐related genes were analyzed using data from The Cancer Genome Atlas (TCGA)‐SKCM cohort (n = 353). Prognostic cell death index (CDI) was established and validated through survival analysis and predictive modeling. Functional enrichment, protein‐protein interaction (PPI), consensus clustering, and tumor microenvironment assessment and drug sensitivity analysis were performed to elucidate the biological and clinical relevance of CDI.ResultsCDI effectively stratified SKCM patients into high and low‐risk groups, demonstrating significant differences in survival outcomes. It exhibited predictive value for survival at 1, 3, and 5 years. The concordance index (C‐index) was 0.794 in the training set, and 0.792 and 0.821 in the internal and external validation sets, respectively. The corresponding area under curve (AUC) was all above 0.75 in these data sets. Functional enrichment analysis revealed significant associations with immune response and inflammatory processes. PPI analysis identified key molecular modules associated with apoptosis and chemokine signaling. Consensus clustering unveiled three discernible subtypes demonstrating notable disparities in survival outcomes based on CDI expression profiles. Assessment of the tumor microenvironment highlighted correlations with immune cell infiltration such as M1 macrophages and T cells. Drug sensitivity analysis indicated tight correlations between CDI levels and response to immunotherapy.ConclusionOur comprehensive analysis establishes the prognostic significance of PCD‐related genes in SKCM. CDI emerges as a promising prognostic biomarker, offering insights into tumor biology and potential implications for personalized treatment strategies. Further validation and clinical integration of CDI are warranted to improve SKCM management and patient outcomes.
The impact of surgery resident training on the duration of tibial plateau leveling osteotomy surgery
Authors: Niida Atsushi , Chou Po‐Yen , Filliquist Barbro , Marcellin‐Little Denis J. , Kapatkin Amy S. , Kass Philip H. 
Published: May 2024

AbstractObjectiveTo investigate the impact of surgery resident training on surgery duration in tibial plateau leveling osteotomy (TPLO) and evaluate whether surgery duration differs with each year of residency training.Study designRetrospective medical record review.AnimalsA total of 256 client‐owned dogs underwent TPLO.MethodsRecords of dogs that underwent TPLO between August 2019 and August 2022 were reviewed. The effects of the surgeon (faculty/resident) and the procedure (arthrotomy/arthroscopy) on TPLO surgery duration were examined with an analysis of variance, and geometric least squares means (GLSM) were compared. A linear mixed effects model (LMM) was fitted to quantify fixed and random effects.ResultsFour faculty surgeons performed 74 (29%) TPLOs, while 10 residents performed 182 (71%) TPLOs under the direct supervision of a faculty surgeon. All TPLOs were conducted with arthrotomy (109; 43%) or arthroscopy (147; 57%). Overall, residents (GLSM, 153 min) required 54% more surgery duration than faculty surgeons (GLSM, 99 min). Surgery duration among first‐year residents (GLSM, 170 min) was 15% longer than second‐ (GLSM, 148 min) and third‐year (GLSM, 147 min) residents, whereas the duration did not differ statistically between second‐ and third‐year residents. Arthroscopy, meniscal tear treatment, surgery on the right stifle, and increasing patient weight were also associated with longer surgery duration.ConclusionThe duration of TPLO surgery significantly decreased after the first year of residency, but did not decrease afterward.Clinical significanceThe results will aid with resource allocation, curricula planning, and cost management associated with resident training.
Large‐scale integrative taxonomy of Swedish grass flies (Diptera, Chloropidae) reveals hitherto unknown complexity of a dark taxon
Authors: Riccardi Paula Raile , Hartop Emily 
Published: May 2024

AbstractThe study of biodiversity is fundamental to preserving life on Earth but a challenging endeavour due to the taxonomic neglect associated with hyperdiverse lineages. To overcome this problem, we have implemented for the first time a Large‐scale integrative taxonomic (LIT) approach on the hyperdiverse insect family Chloropidae. This lineage of flies is a great fit for implementing emerging protocols such as LIT due to their ecological relevance, abundance and global distribution, poorly known genetic diversity and challenging taxonomy. In this study, we test cost‐effective barcoding workflows on nonoptimally preserved chloropid flies from Sweden and then apply targeted morphological validation to accelerate the species recognition process. Our dataset yielded DNA barcodes of 63 species that represent almost one‐third of the species diversity from Sweden and 15% of the European diversity. Applying LIT allowed us to uncover two new species and address for the first time three troublesome species complexes through a comprehensive framework. We also provide previously unknown DNA barcodes for 35% of the described species found and address distribution patterns with a focus on grassland environments. We have thus contributed significantly to overcoming the taxonomic neglect of this hyperdiverse lineage by tackling the diversity of chloropids using complementary sources of data, scalable techniques and quickly translating multiple sources of evidence into named species.
Improving Wind Power Forecast Accuracy for Optimal Hybrid System Energy Management
Authors: Rim Ben Ammar , Mohsen Ben Ammar , Oualha Abdelmajid 
Published: May 2024

Abstract
Due to its renewable and sustainable features, wind energy is growing around the world. However, the wind speed fluctuation induces the intermittent character of the generated wind power. Thus, wind power estimation, through wind speed forecasting, is very inherent to ensure effective power scheduling. Four wind speed predictors based on deep learning networks and optimization algorithms were developed. The designed topologies are the multilayer perceptron neural network, the long short-term memory network, the convolutional short-term memory network, and the bidirectional short-term neural network coupled with Bayesian optimization. The models' performance was evaluated through evaluation indicators mainly, the root mean squared error, the mean absolute error, and the mean absolute percentage. Based on the simulation results, all of them show considerable prediction results. Moreover, the combination of the long short-term memory network and the optimization algorithm is more robust in wind speed forecasting with a mean absolute error equal to 0.23 m/s. The estimated wind power was investigated for optimal Wind/Photovoltaic/Battery/Diesel energy management. The handling approach lies in the continuity of the load supply through the renewable sources as a priority, the batteries on the second order, and finally the diesel. The proposed management strategy respects the designed criteria with a satisfactory contribution percentage of renewable sources equal to 71%.
Influence of Injection Timing Variation on Combustion-Emission-Performance Aspects of Emulsified Plastic Oil-Run Compression Ignition Engine
Authors: Saha Dipankar , Roy Bidesh , Kundu Patit Paban 
Published: May 2024

Abstract
This study investigates the influence of injection timing (IT) on combustion-emission-performance aspects of the compression ignition (CI) engine, running with emulsified plastic oil (EPO). The IT was advanced to 25 deg before the top dead center (bTDC) as well as retarded to 21 deg bTDC for the EPO-run engine, and the obtained results were compared with EPO and neat diesel-run engine at standard IT (23 deg bTDC). At full load, the peak cylinder pressure increased to 64.7 bar when the IT was advanced to 25 deg bTDC. The corresponding peak heat release rate also increased to 40.29 J/crank angle due to the advancement of IT in comparison with the standard IT. The brake-specific fuel consumption also improved at all loading conditions. However, the advancement of IT increased the nitrogen oxides (NOx) and temperature of exhaust gas slightly. In addition, 25 deg bTDC for EPO also reduced the unburnt hydrocarbon (HC), carbon monoxide (CO), and smoke emissions with respect to the standard IT. Largely, the advanced IT improved the majority of the engine characteristics for EPO except for the NOx, but that is also lower than diesel-run operation. Thus, 25 deg bTDC (for EPO) exhibits promising potential to be implemented in CI engines.
Modeling of a Photovoltaic/Thermal Hybrid Panel for Residential Hot Water System
Authors: Odeh Saad , Aden Ilyas 
Published: May 2024

Abstract
Despite the extensive body of research on photovoltaic (PV)/thermal systems, a gap remains in evaluating their performance in residential settings. This study aims to bridge this gap by focusing on the energy modeling of a PV/Thermal (PVT) hybrid panel that incorporates heat pipe technology. The evaluation is conducted through MATLAB code to assess the system's capability to fulfill the electricity and heating demands of residential buildings. The model's reliability is affirmed by comparing it with experimental data from a PVT panel tested in Sydney, exploring the transient variations in both water heat gain rates and power generation. The model's precision is evident from the percentage of error in the estimated temperatures of the PV panel based on the test results under various weather conditions, which ranged from −8% to 6%. This method was also utilized to determine the overall energy efficiency of the PVT panel under different climatic conditions. The results reveal that the overall energy efficiency of the proposed PVT panel, on a typical day, is approximately 45%, significantly outperforming traditional PV panels by more than double. Furthermore, the payback period for a typical residential PVT system, providing both hot water and electricity, is found substantially shorter than that of installing separate PV and solar hot water systems, highlighting the economic and environmental benefits of the proposed hybrid system.