bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of an in-hospital medication self-management intervention (SelfMED) on medication adherence in polypharmacy patients postdischarge: protocol of a pre–post intervention study
Authors: Mortelmans Laura , Goossens Eva , Dilles Tinne 
Published: May 2024

IntroductionHealthcare providers usually manage medication for patients during hospitalisation, although patients are expected to self-manage their medication after discharge. A lack of self-management competencies is found to be associated with low adherence levels and medication errors harming patients’ health. Currently, patients seldom receive support or education in medication self-management. When self-management is allowed during hospitalisation, it is rarely provided using a structured, evidence-based format. Therefore, an in-hospital medication self-management intervention (ie, SelfMED) was developed based on current evidence. To date, empirical data demonstrating the effect of SelfMED on medication adherence are lacking. This study primarily aims to evaluate the effect of the SelfMED intervention on medication adherence 2 months postdischarge in polypharmacy patients, as compared with usual care.Methods and analysisA multicentre pre–post intervention study will be conducted. The study will start with a control phase investigating usual care (ie, medication management entirely provided by healthcare providers), followed by an intervention period, investigating the effects of the SelfMED intervention. SelfMED consists of multiple components: (1) a stepped assessment evaluating patients’ eligibility for in-hospital medication self-management, (2) a monitoring system allowing healthcare providers to follow up medication management and detect problems and (3) a supportive tool providing healthcare providers with a resource to act on observed problems with medication self-management. Polymedicated patients recruited during the control and intervention periods will be monitored for 2 months postdischarge. A total of 225 participants with polypharmacy should be included in each group. Medication adherence 2 months postdischarge, measured by pill counts, will be the primary outcome. Secondary outcomes include self-management, medication knowledge, patient and staff satisfaction, perceived workload and healthcare service utilisation.Ethics and disseminationThe ethics committee of the Antwerp University Hospital approved the study (reference no: B3002023000176). Study findings will be disseminated through peer-reviewed publications, conference presentations and summaries in layman’s terms.Trial registration numberISRCTN15132085.
Influence of paternal preconception health on pregnancy, intrapartum, postpartum and early childhood outcomes: protocol for a parallel scoping review
Authors: Dennis Cindy-Lee , Abbass-Dick Jennifer , Birken Catherine , Dennis-Grantham Alistair , Goyal Deepika , Singla Daisy , Letourneau Nicole , McQueen Karen , Shorey Shefaly , Dol Justine 
Published: May 2024

IntroductionPreconception care is the provision of behavioural, social or biomedical interventions to women and couples prior to conception. To date, preconception research has primarily focused on maternal health, despite the male partner’s contribution before birth to both short-term and long-term child outcomes. The objectives of the reviews are: (1) to identify, consolidate and analyse the literature on paternal preconception health on pregnancy and intrapartum outcomes, and (2) to identify, consolidate and analyse the literature on paternal preconception health on postpartum and early childhood outcomes.Methods and analysisA scoping review will be conducted following the Joanna Briggs Institute methodology. MEDLINE, PsycINFO, Embase, Scopus and CINAHL databases will be searched for articles published in English. Two independent reviewers will screen titles and abstracts and then full text using Covidence, with conflicts resolved by a third reviewer. Data extraction will be performed using Covidence.Ethics and disseminationEthics approval is not required for this scoping review. Results will be published in peer-reviewed journals as well as presented at relevant national and international conferences and meetings.
Preventing postnatal depression in new mothers using telephone peer support: protocol for the DAISY (Depression and AnxIety peer Support studY) multi-centre randomised controlled trial
Authors: Shafiei Touran , McLachlan Helen L , Dennis Cindy-Lee , Nicholson Jan M , Nguyen Tram , Shiell Alan , Nguyen Cattram D , Grimes Heather , Bee Jessica , Adams Catina , Callander Emily , Forster Della A 
Published: May 2024

IntroductionPostnatal depression affects up to one in six new mothers in Australia each year, with significant impacts on the woman and her family. Prevention strategies can be complicated by a woman’s reluctance to seek professional help. Peer support is a promising but inadequately tested early intervention. Very few trials have reported on the efficacy of peer support in the perinatal period and no study has been undertaken in Australia. We will explore if proactive telephone-based peer (mother-to-mother) support, provided to women identified as being at high risk of postnatal depression, impacts on clinically significant depressive symptomatology at 6 months postpartum.Methods and analysisThis is a protocol for a single-blinded, multi-centre, randomised controlled trial conducted in Melbourne, Australia. Eligible women will be recruited from either the postnatal units of two maternity hospitals, or around 4 weeks postpartum at maternal and child health centres within two metropolitan council areas. A total of 1060 (530/group) women will be recruited and randomly allocated (1:1 ratio) to either—usual care, to receive the standard community postpartum services available to them, or the intervention group, to receive proactive telephone-based support from a peer volunteer for 6 months, in addition to standard community services. Primary outcome: clinically significant depressive symptomatology at 6 months postpartum as measured using the Edinburgh Postnatal Depression Scale. Secondary outcomes: symptoms of anxiety and/or stress, health-related quality of life, loneliness, perception of partner support, self-rated parenting, child health and development, infant feeding and health service use. The cost-effectiveness of the intervention relative to standard care will also be assessed.Ethics and disseminationEthics approval has been obtained from La Trobe University, St. Vincent’s Hospital, the Royal Women’s Hospital, Northern Health, Victorian Department of Health and Human Services and Victorian Department of Education and Training. Written informed consent will be obtained from all participants before randomisation. Trial results will be disseminated through peer-reviewed publications, conference presentations and a higher degree thesis.Trial registration numberACTRN12619000684123; Australian New Zealand Clinical Trials Registry.
Pharmacists in Trauma: a randomised controlled trial of emergency medicine pharmacists in trauma response teams
Authors: Roman Cristina , Dooley Michael , Fitzgerald Mark , Smit De Villiers , Cameron Peter , Mitra Biswadev 
Published: May 2024

BackgroundAnalgesia is an important component for patient well-being, but commonly delayed during trauma resuscitation. The Pharmacists in Trauma trial assessed the effects of integrating pharmacists into trauma response teams to improve analgesia delivery and medication management.MethodsThis unblinded randomised trial compared emergency medicine (EM) pharmacist involvement in trauma callouts versus standard care at an Australian level 1 trauma centre. Randomisation was performed via an online single sequence randomisation service. Eligible patients included those managed with a trauma callout during working hours of an EM pharmacist. Pharmacists were able to prescribe medications using a Partnered Pharmacist Medication Charting model. The primary outcome was the proportion of patients who had first dose analgesia within 30 min compared using the χ2test.ResultsFrom 15 July 2021 until 31 January 2022, there were 119 patients randomised with 37 patients excluded as no analgesia was required. There were 82 patients included for analysis, 39 in the control arm and 43 in the intervention arm. The primary outcome was achieved in 25 (64.1%) patients in the control arm and 36 (83.7%) patients in the pharmacist arm (relative risk 1.31; 95% CI 1.0 to 1.71; p=0.042). Time to analgesia in the control arm was 28 (22–35) mins and 20 (15–26 mins) with pharmacist involvement; p=0.025. In the pharmacist arm, the initial dose of analgesia was prescribed by the pharmacist for 38 (88.4%) patients. There were 27 other medications prescribed by the pharmacist for the management of these patients. There were no differences in emergency and trauma centre or hospital length of stay.ConclusionAddition of the EM pharmacist in trauma response teams improved time to analgesia. Involvement of an EM pharmacist in trauma reception and resuscitation may assist by optimising medication management, with members of the team more available to focus on other life-saving interventions.Trial registration numberACTRN12621000338864.
Combined analysis of albumin in situ hybridisation and C reactive protein immunohistochemistry for the diagnosis of intrahepatic cholangiocarcinoma: towards a molecular classification paradigm
Authors: Albrecht Thomas , Rossberg Annik , Rose Fabian , Breuhahn Kai , Baumann Eva-Marie , Tóth Marcell , Brinkmann Fritz , Charbel Alphonse , Vogel Monika Nadja , Köhler Bruno , Mehrabi Arianeb , Büchler Markus Wolfgang , Singer Stephan , Solass Wiebke , Straub Beate , Schirmacher Peter , Roessler Stephanie , Goeppert Benjamin 
Published: May 2024

AimsIntrahepatic cholangiocarcinoma (iCCA) is a diagnosis of exclusion that can pose a challenge to the pathologist despite thorough clinical workup. Although several immunohistochemical markers have been proposed for iCCA, none of them reached clinical practice. We here assessed the combined usage of two promising diagnostic approaches, albumin in situ hybridisation (Alb-ISH) and C reactive protein (CRP) immunohistochemistry, for distinguishing iCCA from other adenocarcinoma primaries.MethodsWe conducted Alb-ISH and CRP immunohistochemistry in a large European iCCA cohort (n=153) and compared the results with a spectrum of other glandular adenocarcinomas of different origin (n=885). In addition, we correlated expression patterns with clinicopathological information and mutation data.ResultsAlb-ISH was highly specific for iCCA (specificity 98.8%) with almost complete negativity in perihilar CCA and only rare positives among other adenocarcinomas (sensitivity 69.5%). CRP identified the vast majority of iCCA cases (sensitivity 84.1%) at a lower specificity of 86.4%. Strikingly, the combination of CRP and Alb-ISH boosted the diagnostic sensitivity to 88.0% while retaining a considerable specificity of 86.1%. Alb-ISH significantly correlated with CRP expression, specific tumour morphologies and small or large duct iCCA subtypes. Neither Alb-ISH nor CRP was associated with iCCA patient survival. 16 of 17 recurrent mutations in either IDH1, IDH2 and FGFR2 affected Alb-ISH positive cases, while the only KRAS mutation corresponded to an Alb-ISH negative case.ConclusionsIn conclusion, we propose a sequential diagnostic approach for iCCA, integrating CRP immunohistochemistry and Alb-ISH. This may improve the accuracy of CCA classification and pave the way towards a molecular-guided CCA classification.
Investigating somatic variants and pathways in mismatch repair-deficient (dMMR) colorectal carcinoma in South Africa
Authors: Aldera Alessandro Pietro , van der Westhuizen Jana , Tsai Wan-Jung , Krause May J , Yildiz Safiye , Pillay Komala , Boutall Adam , Ramesar Raj 
Published: May 2024

AimsColorectal carcinoma (CRC) is a common cause of morbidity and mortality worldwide, and an emerging public health problem in sub-Saharan Africa. Several authors have described an increased frequency of mismatch repair-deficient (dMMR) CRC in sub-Saharan Africa, but these tumours remain poorly characterised molecularly. We sought to interrogate the somatic molecular genetic landscape of dMMR CRC in a cohort of young patients to better inform Lynch syndrome (LS) screening strategies and personalised medicine approaches in our setting.Methods32 patients (aged <60 years) were identified with dMMR CRC. DNA was extracted from selected formalin-fixed paraffin-embedded (FFPE) tissue resection samples and subjected to amplicon-based next-generation sequencing (NGS).ResultsPathogenic or likely pathogenic variants were detected in the corresponding MMR gene in 14 of 18 (78%) MLH1/PMS2-deficient tumours, 5 of 8 (63%) MSH2/MSH6-deficient tumours, 1 of 4 (25%) tumours with isolated MSH6 loss and 0 of 2 tumours with isolated PMS2 loss. Previously unreported variants were identified inMLH1(three) andMSH2(one). Cases with a variant allele frequency suggesting a germline mutation were identified inMLH1(eight),MSH2(two) andMSH6(one). Only one MMR gene variant was detected in more than one patient (MLH1p.Q510*). FourPOLE/POLD1exonuclease domain variants were identified, one of which was previously unreported.ConclusionThe spectrum of disease-causing MMR gene variants in our population necessitates NGS testing for LS screening. This study also highlights the role of somatic testing on readily available FFPE samples to generate data on the epidemiology of CRC in different settings.
Immediate response in markers of inflammation and angiogenesis during exercise: a randomised cross-over study in heart transplant recipients
Authors: Yardley Marianne , Ueland Thor , Aukrust Pål , Michelsen Annika , Bjørkelund Elisabeth , Gullestad Lars , Nytrøen Kari 
Published: May 2024

BackgroundThe present study explored and compared the immediate responses in markers of inflammation and angiogenesis in maintenance heart transplant (HTx) recipients before, during and after sessions of high-intensity interval training (HIT) versus moderate-intensity continuous training (MICT). The study aimed to explain some of the trigger mechanisms behind HIT in HTx recipients.MethodsThis cross-over study included 14 HTx patients (mean±SD age: 53±13 years; time since HTx, 3±2 years). All participants underwent baseline blood samples and a cardiopulmonary exercise test during their first visit. The next two visits included one HIT session and one MICT session, in randomised order. Blood samples were taken during and after each exercise session. Myokines and inflammatory markers related to vascular inflammation, blood-platelet activation and modulation of angiogenesis were analysed.ResultsThe main findings in this study were (1) exercise, regardless of intensity, induced a significant immediate response in several vascular, angiogenetic and in particular platelet-derived inflammatory mediators in HTx recipients. (2) HIT showed trends to induce an increased response in von Willebrand factor, vascular endothelial growth factor-1 and angiopoetin-2, and a decreased response in growth differentiation factor-15, compared with MICT.ConclusionsThis pattern and in particular the trend towards an increased angiogenetic mediator response could contribute to the beneficial effects of HIT in HTx recipients.Trial registration numberNCT02602834.
US adolescents’ response to nicotine warning labels in influencer e-cigarette marketing social media posts: a survey-based randomised between-subject experiment
Authors: Vassey Julia , Vogel Erin A , Unger Jennifer B 
Published: May 2024

BackgroundE-cigarette promotional posts with misleading nicotine warning labels on social media may lower adolescents’ risk perceptions of e-cigarettes. A between-subject experiment assessed effects of influencers’ e-cigarette promotional posts with different nicotine warning labels on adolescents’ e-cigarette harm perceptions, susceptibility to e-cigarette use and perceptions of influencer credibility.MethodsIn 2022, adolescents (N=1864, Mage=17 (SD=0.6)) were randomised to view six images and videos featuring influencers promoting e-cigarettes in one of five experimental conditions: two conditions with a ‘tobacco-free nicotine’ warning label (placed on an e-cigarette in the post or at the top of the post), two conditions with the US Food and Drug Administration (FDA) nicotine warning label (on an e-cigarette in the post or at the top of the post (control)) and one no-label condition. Participants rated influencers’ credibility (eg, honesty). Harm perceptions of, and susceptibility to use, e-cigarettes were then assessed.ResultsParticipants who viewed posts with the FDA warning label at the top of the post perceived influencers as more honest, trustworthy and informed than in all the other conditions. E-cigarette never-users who viewed posts with a ‘tobacco-free nicotine’ warning label pictured on an e-cigarette (compared with the FDA label at the top of a post) were more likely to report susceptibility to e-cigarette use (adjusted OR 1.79, 95% CI 1.17 to 2.73).ConclusionsAlterations of the required nicotine warning labels can make them less effective in deterring e-cigarette use behaviour. Tobacco control authorities could increase enforcement of the FDA-required nicotine warning labels and harness influencers for antitobacco messaging.
Robert Millikan, Japanese internment, and eugenics
Authors: Hales Thomas 
Published: May 2024

AbstractRobert A. Millikan (1868–1953) was the second American to win the Nobel Prize in physics. At the peak of his influence, no scientist save Einstein was more admired by the American public. Millikan, the head of the California Institute of Technology (Caltech) during its first 24 years, oversaw its rapid growth into one of the leading scientific institutions of the world. However, in response to demands for social justice following the murder of George Floyd, Caltech launched an investigation into Millikan. Caltech reached a decision to strip Millikan of honors (such as the library named after him), following accusations from various sources that he was a sexist, racist, xenophobic, antisemitic, pro-eugenic Nazi sympathizer. In short, Caltech threw the book at him. This article analyzes two accusations against Millikan. The first of these accusations was published in Nature: that he collaborated to deprive Japanese Americans of their rights during their forced relocation to internment camps during the Second World War. An examination of original historical sources will show that this accusation is false. On the contrary, Millikan actively campaigned during the war to promote the rights of Japanese Americans. This article traces the stages of misrepresentation that led to current false beliefs about Millikan. In view of Millikan’s extraordinary position in American science, this misrepresentation is a cautionary tale. The article also treats Caltech’s central accusation against Millikan: he lent his name to “a morally reprehensible eugenics movement” that had been scientifically discredited in his time. The article considers the statements purporting to show that eugenics movement had been denounced by the scientific community by 1938. In a reversal of Caltech’s claims, all three of Caltech’s scientific witnesses against eugenics—including two Nobel laureates—were actually pro-eugenic to varying degrees. This article concludes that Millikan’s beliefs fell within acceptable scientific norms of his day.
Gyrotactic bio-magneto-convective combined impacts on magnetorheological hybrid nanoflow: Microbial life on surfaces’ application
Authors: Sreenivasulu P. , Poornima T. , Souayeh Basma 
Published: May 2024

Magnetorheological fluid with self-driven ubiquitous motile organisms was affected by various physical factors such as hydrodynamics, dispersion, and distribution of organisms. These fascinating properties attracted us to work on this paper, a Casson hybrid nanoflow model exploring the dynamic behavior of microorganisms along spongy extensible surfaces taking Ohmic heating and chemical reaction into account. Further, the heat transfer phenomena are analyzed in the presence of thermal radiation and space and time-dependent energy sources/sinks. The nanoflow has its base methanol and a mixture of iron and aluminum oxides is suspended. Flow obeying mathematical model is solved numerically using the Runge–Kutta–Fehlberg technique along with the shooting method after imposing self-similarity transformation. Results of various pertinent parameters on the flow characteristic quantities and engineering quantities are portrayed and presented through graphs and tables. Iron oxide methanol nanofluid shows supremacy over hybrid nanoflows as speed is considered, whilst the opposite phenomenon is observed in the case of energy. Hybrid nanoflow makes the surface friction-free. Microorganism concentration difference improvement also helps in the intensification of motile organism growth.
AACR Cancer Disparities Progress Report 2024: Achieving the Bold Vision of Health Equity
Authors: Williams Patrick A. , Zaidi Sayyed K. , Ramian Haleh , Sengupta Rajarshi 
Published: May 2024

Abstract
Advances in cancer prevention, early detection, and treatments have led to unprecedented progress against cancer. However, these advances have not benefited everyone equally. Because of a long history of structural inequities and systemic injustices in the United States, many segments of the US population continue to shoulder a disproportionate burden of cancer. The American Association for Cancer Research (AACR) Cancer Disparities Progress Report 2024 (CancerDisparitiesProgressReport.org) outlines the recent progress against cancer disparities, the ongoing challenges faced by medically underserved populations, and emphasizes the vital need for further advances in cancer research and patient care to benefit all populations.
HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity
Authors: Rana Priyanka S. , Ignatz-Hoover James J. , Kim Byung-Gyu , Malek Ehsan , Federov Yuriy , Adams Drew , Chan Timothy , Driscoll James J. 
Published: May 2024

Abstract

Proteasomes degrade intracellular proteins to generate antigenic peptides that are recognized by the adaptive immune system and promote anticancer immunity. However, tumors subvert the antigen presentation machinery to escape immunosurveillance. We hypothesized that proteasome activation could concomitantly increase antigen abundance and diversity in multiple myeloma cells. High-throughput screens revealed that histone deacetylase 6 (HDAC6) inhibitors activated proteasomes to unmask neoantigens and amplify the tumor-specific antigenic landscape. Treatment of patient CD138+ cells with HDAC6 inhibitors significantly promoted the antimyeloma activity of autologous CD8+ T cells. Pharmacologic blockade and genetic ablation of the HDAC6 ubiquitin-binding domain released HR23B, which shuttles ubiquitinylated cargo to proteasomes, while silencing HDAC6 or HR23B in multiple myeloma cells abolished the effect of HDAC6 inhibitors on proteasomes, antigen presentation, and T-cell cytotoxicity. Taken together, our results demonstrate the paradigm-shifting translational impact of proteasome activators to expand the myeloma immunopeptidome and have revealed novel, actionable antigenic targets for T cell–directed immunotherapy.

Significance:
The elimination of therapy-resistant tumor cells remains a major challenge in the treatment of multiple myeloma. Our study identifies and functionally validates agents that amplify MHC class I–presented antigens and pave the way for the development of proteasome activators as immune adjuvants to enhance immunotherapeutic responses in patients with multiple myeloma.