bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent vestibular paroxysms associated with systemic hypertension in a dog
Authors: Bentley R. Timothy , March Philip A. 
Published: September 2011

Abstract
Case Description—A 9-year-old 19.7-kg (43.3-lb) spayed female Australian Shepherd was examined for an increase in frequency of episodic neurologic signs, often occurring upon exercise.
Clinical Findings—Between episodes of neurologic signs, the dog was considered clinically normal on the basis of findings on physical and neurologic examinations. An episode of ataxia with central vestibular signs was induced by exercising the patient in the hospital. All clinicopathologic values were within reference ranges, as were findings on magnetic resonance imaging of the brain and peripheral vestibular system. Systolic blood pressures of 180 to 200 mm Hg were recorded, and systemic hypertension was diagnosed.
Treatment and Outcome—While the dog received amlodipine and enalapril, blood pressure returned to within reference range, and episodes of neurologic signs no longer occurred. When clinical signs later recurred, systolic blood pressure was again found to be high. Following an increase in medication dosage, blood pressure normalized, and only 4 further episodes of neurologic signs were observed during a follow-up period totaling 30 months.
Clinical Relevance—Transient ischemic attack is a common diagnosis in humans but has not been described for dogs. In humans, it is defined as focal brain dysfunction caused by vascular disease that resolves completely in less than 24 hours and is often recurrent. Systemic hypertension is one of the most common preexisting conditions. We propose that the dog in the present report had clinical signs and diagnostic test results supportive of a diagnosis of transient ischemic attack.
Reliability of a Brief Scale for Assessment of Coronary-Prone Behavior and Standard Measures of Type a Behavior
Authors: Young Laurens D. , Barboriak Joseph J. 
Published: September 2011

45 male volunteers were classified by the Structured Interview for Type A behavior and also by the Jenkins Activity Survey. Each subject also responded to a series of 10 questions taken from the Milwaukee Cardiovascular Life Quality Questionnaire. 10 items of the questionnaire were tested to form a scale, the Milwaukee questionnaire—10 for the classification of Type A and B coronary-prone behavior. Each response was rated as one if it was in the previously defined direction of Type A or as zero if in Type B direction. The mean response in this population was 3.56. Subjects scoring 0 to 3 were then classified as Type B and those scoring 4 and more as Type A. Subjects were also given two standard measures of Type A behavior, the Jenkins survey and the structured interview. Comparisons of Type A vs B classes were made between the Milwaukee questionnaire and the interview and the Jenkins survey. High agreement rating Type A behavior was found among instruments. The 10 items appear to provide a reliable and brief scale for rating Type A coronary-prone behavior.
Role of LPXRFamide peptide in the neuroendocrine regulation of reproduction in fish
Authors: Shahjahan Md. , Ando Hironori 
Published: September 2011

Abstract
The decapeptide gonadotropin-releasing hormone (GnRH) is the primary factor responsible for the hypothalamic control of gonadotropin (GTH) secretion. This review focuses on a family of neuropeptides, LPXRFamide (LPXRFa) peptides, which have been implicated in the regulation of GTH secretion. LPXRFa acts on the pituitary via a G protein-coupled receptor, LPXRFa-R, to enhance gonadal development and maintenance by increasing gonadotropin release and synthesis. Because LPXRFa exists and functions in several fish species, LPXRFa is considered to be a key neurohormone in fish reproduction control. The precursors to LPXRFamide peptides encoded plural LPXRFamide peptides and were highly divergent in vertebrates, particularly in lower vertebrates. Tissue distribution analyses indicated that LPXRFamide peptides were highly concentrated in the hypothalamus and other brainstem regions. In view of the localization and expression of LPXRFamide peptides in the hypothalamo-hypophysial system, LPXRFamide peptide in fish increase GTH release in vitro and in vivo. This review summarizes the advances made in our understanding of the biosynthesis, mode of action and functional significance of LPXRFa, a newly discovered key neurohormone.
Formulation: A Proposal for a More Structured, Longitudinal Approach
Authors: Reilly John , Newton Richard 
Published: September 2011

Objective: The aim of this study was to consider formulation enabling a longitudinal perspective to improve the quality of clinical information. Method: An overview of RANZCP guidelines for formulation, our observations of formulation in practice, and consideration of the requirements of current clinical documentation systems were employed. Results: A five paragraph structured approach to formulation, with an example, is proposed. Conclusion: A structured schema for longitudinal formulation offers advantages for mental health services working over time with consumers with severe and enduring illnesses and should be considered in the development of clinical information systems.
Fixed Point for Weakly Compatible Maps Satisfying Generalized Contraction Principle
Authors: Mehta J. , Joshi M. L. 
Published: September 2011

We prove common fixed point theorems for a pair of weakly compatible mappings satisfying a generalized contraction principle by using a control function and implicit relation. We also establish invariant approximation result as an application of the result.Keywords: Common fixed point; Weakly compatible maps; Control function; Invariant approximation.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i3.6476 J. Sci. Res. 3 (3), 549-555 (2011)
Ring Opening of Spiroepoxides Dithianedioxide with Bis-nucleophiles
Authors: Ritmaleni R. , Aggarwal V. K. 
Published: September 2011

This research was aimed to apply the spiroepoxide dithianedioxide for the synthesis of amino acid via ring opening of the spiroepoxide by bis-nucleophiles. First attempt was made to synthesize the bis-nucleophiles, amino alcohol, which was eventually used to the ring opening reaction of the spiroepoxide to produce the morpholine ring compound. The reaction was carried out in racemic and asymmetric method with moderate yield and high 99%. The last step produced amino acid that was still remained unsuccessful. However, it cannot be concluded yet whether the spiroepoxide dithianedioxide is the right intermediate for the synthesis of amino acid.Keywords: Amino alcohol; Morpholine ring; Spiroepoxide dithianedioxide; Amino acid.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: 10.3329/jsr.v3i3.6746 J. Sci. Res. 3 (3), 585-596 (2011)
<i>In vitro</i> Transdermal Delivery of Metformin from a HPMC/ PVA Based TDS-patch at Different pH
Authors: Jahan L. , Ferdaus R. , Shaheen S. M. , Sultan M. Z. , Mazid M. A. 
Published: September 2011

In order to evaluate the pHs effect on the transdermal drug delivery, HPMC/PVA based TDS-patch was prepared. In vitro transdermal dissolution was performed at 32 oC at different pHs. Comparatively higher release rate was found in case of pH 7.4 than those of others. pHs 5.4 and 8 showed almost the same release pattern. The release fashion was Higuchi type of diffusion controlled release. This result showed that neutral pH would accumulate the maximum drug from such a TDS patch, where the skin pH (around 5.4) does not support such a release. Sustained release of drug from such a patch prefers skin pH rather than neutral pH.Keywords: Transdermal drug delivery; Higuchi diffusion; Release rate; Metformin.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i3.7422 J. Sci. Res. 3 (3), 661-667 (2011)
Elastic Behavior of <i>&gamma;</i>-Li<sub>3</sub>N under Pressure
Authors: Hossain M. A. , Islam A. K. M. A. 
Published: September 2011

The elastic properties of gamma-Li3N have been studied for the first time by first-principles method. Three independent elastic constants, aggregate elastic moduli (B, G, E), Poissons ratio and Debye temperature are calculated as a function of pressure from 37.12 (beta to gamma transition value) to 200 GPa and the implications of the results are discussed.Keywords: Li3N; Gamma-phase; Elastic properties; Debye temperature.© 2011 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi:10.3329/jsr.v3i3.7832 J. Sci. Res. 3 (3), 579-584 (2011)
L'équité dans le modèle de "concurrence organisée" pour la régulation d'un système de santé
Authors: Gadreau Maryse , Schneider-Bunner Claude 
Published: September 2011

Equity in the "Planned Competition" Model of Regulating a Health System by Maryse Gadreau and Claude Schneider-Bunner
The distributive logic of European health systems (contribution depending on income and use depending on need) is indicative of the importance attached to the principle of equal access to health-care. However, reforms introducing competition are arousing interest in Europe and have been piloted in the United Kingdom and the Netherlands. To what extent is equity still maintained? This paper uses a threefold typology of justice theories (egalitarian, liberal and Rawlsian) to analyse the "planned competition" model and its European pilots. The underlying conception of equity is ambiguous: all three dimensions are present, indicating the hesitations of equity policy and reflecting the pluralism of the principles in whose name the health system players are acting.
Mesurer l'influence de la fiscalité sur la localisation des entreprises
Authors: Houdebine Michel , Schneider Jean-Luc 
Published: September 2011

Measuring the Influence of Taxation on Business Location Choices by Michel Houdebine and Jean-Luc Schneider
The paper attempts to model business location choices and the choice of tax rates by local authorities. Methods for estimating the sensitivity of business location choices to taxation are derived and then applied to the 36,000 local business tax rates observed in French communes and the actual location of businesses. The various estimators of sensitivity to taxation derived all provide the same relatively small order of magnitude. The results may be used to assess the cost effectiveness of local tax incentives.
Pertes de bien-être et pouvoir de marché dans l'agro-alimentaire français
Authors: Lavergne Pascal , Réquilllart Vincent , Simioni Michel 
Published: September 2011

Losses of Welfare and Market Power in the French Food Industry by Pascal Lavergne, Vincent Réquillart and Michel Simioni
We study the practical problems of estimating losses of welfare resulting from market power. Particular attention is paid to the specification of demand functions, the evaluation of deviations between marginal costs and prices and the calculation of Hicksian losses of welfare. We evaluate the losses of welfare for 31 French food sectors and show that the Marshallian consumers' surplus measurement is a good approximation of the Hicksian surplus measurement. However, the Marshallian loss of welfare measurement does not provide a good approximation of the corresponding Hicksian measurement. Lastly, the different approximations of the marginal cost-price deviation produce considerably different sector rankings by extent of losses of welfare.
Cycles de la production industrielle : une analyse historique dans le domaine des fréquences
Authors: Villa Pierre 
Published: September 2011

Cycles de la production industrielle : une analyse historique dans le domaine des fréquences
par Pierre Villa
Nous étudions les cycles par la méthode ARFIMA. Nous calculons des séries mensuelles de taux de chômage et de production industrielle, puis nous les filtrons par Holt et Winters puis par de Geweke et Porter-Husak pour retirer la tendance à mémoire longue correspondant à un processus d'intégration fractionnaire. Nous estimons les fluctuations mesurées par la différence entre la série corrigée des variations saisonnières et la tendance longue mesurée par la Fourier inverse du processus fractionnaire. Il n'y a pas de cycle régulier Selon la première interprétation, il y un effet de " cliquet ". Selon la deuxième, l'État a depuis la seconde guerre mondiale réduit les fluctuations de forte amplitude enregistrées auparavant par sa gestion de l'activité. Selon la troisième, les chocs aléatoires observés correspondent à une théorie des cycles réels.
Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System
Authors: ØSTERGAARD MIKKEL , BØYESEN PERNILLE , ESHED IRIS , GANDJBAKHCH FRÉDÉRIQUE , LILLEGRAVEN SIRI , BIRD PAUL , FOLTZ VIOLAINE , BOONEN ANNELIES , LASSERE MARISSA , HERMANN KAY-GEERT , ANANDARAJAH ALLEN , DØHN UFFE MØLLER , FREESTON JANE , PETERFY CHARLES G. , GENANT HARRY K. , HAAVARDSHOLM ESPEN A. , McQUEEN FIONA M. , CONAGHAN PHILIP G. 
Published: September 2011

Objective.To develop and validate a magnetic resonance imaging (MRI) method of assessment of joint space narrowing (JSN) in rheumatoid arthritis (RA).Methods.Phase A: JSN was scored 0–4 on MR images of 5 RA patients and 3 controls at 15 wrist sites and 2nd–5th metacarpophalangeal (MCP) joints by 8 readers (7 once, one twice), using a preliminary scoring system. Phase B: Image review, discussion, and consensus on JSN definition, and revised scoring system. Phase C: MR images of 15 RA patients and 4 controls were scored using revised system by 5 readers (4 once, one twice), and results compared with radiographs [Sharp-van der Heijde (SvdH) method].Results.Phase A: Intraobserver agreement: intraclass correlation coefficient (ICC) = 0.99; smallest detectable difference (SDD, for mean of readings) = 2.8 JSN units (4.9% of observed maximal score). Interobserver agreement: ICC = 0.93; SDD = 6.4 JSN units (9.9%). Phase B: Agreement was reached on JSN definition (reduced joint space width compared to normal, as assessed in a slice perpendicular to the joint surface), and revised scoring system (0–4 at 17 wrist sites and 2nd–5th MCP; 0: none; 1: 1–33%; 2: 34–66%; 3: 67–99%; 4: ankylosis). Phase C: Intraobserver agreement: ICC = 0.90; SDD = 6.8 JSN units (11.0%). Interobserver agreement: ICC = 0.92 and SDD = 6.2 JSN units (8.7%). The correlation (ICC) with the SvdH radiographic JSN score of the wrist/hand was 0.77. Simplified approaches evaluating fewer joint spaces demonstrated similar reliability and correlation with radiographic scores.Conclusion.An MRI scoring system of JSN in RA wrist and MCP joints was developed and showed construct validity and good intra- and interreader agreements. The system may, after further validation in longitudinal data sets, be useful as an outcome measure in RA.
Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index-50 Enhances the Ability of SLE Responder Index to Identify Responders in Clinical Trials
Authors: TOUMA ZAHI , GLADMAN DAFNA D. , IBAÑEZ DOMINIQUE , TAGHAVI-ZADEH SHAHRZAD , UROWITZ MURRAY B. 
Published: September 2011

Objective.To evaluate the performance of the Systemic Lupus Erythematosus (SLE) Responder Index (SRI) when the SLE Disease Activity Index 2000 (SLEDAI-2K) is substituted with SLEDAI-2K Responder Index-50 (SRI-50), a valid and reliable index of disease activity improvement. Also, to determine whether the SRI-50 will enhance the ability of SRI in detecting responders.Methods.Our study was conducted on patients who attended the Lupus Clinic from September 2009 to September 2010. SLEDAI-2K, SRI-50, the British Isles Lupus Assessment Group measure, and the Physician’s Global Assessment were determined initially and at followup. SRI was determined at the followup visit according to its original definition using the SLEDAI-2K score and by substituting SLEDAI-2K with SRI-50.Results.A total of 117 patients with SLEDAI-2K ≥ 4 at baseline were studied. Patients had 1 followup visit over a 3-month period. Twenty-nine percent of patients met the original definition of SRI and 35% of patients met the definition of SRI when SLEDAI-2K was substituted with SRI-50. The use of SRI-50 allowed determination of significant improvement in 7 additional patients. This improvement could not be discerned with the use of SLEDAI-2K as a component of SRI. At followup visits that showed improvement, SRI-50 scores decreased to a greater extent than SLEDAI-2K scores (p < 0.0001).Conclusion.SRI-50 enhances the ability of SRI to identify patients with clinically important improvement in disease activity. SRI-50 was superior to SLEDAI-2K in detecting partial clinical improvement, ≥ 50%, between visits. These properties of the SRI-50 enable it to be used as an independent outcome measure of improvement or as a component of SRI in clinical trials.
Une vérité au cœur du délire : Créativité et deuil
Authors: Laufer Laurie 
Published: September 2011

Freud a laissé entendre une « contre-indication » concernant l’expérience analytique auprès des personnes très âgées, considérant que la plasticité et la créativité psychiques étaient moindres et que le patient ne pouvait se livrer à un jeu régressif nécessaire à l’élaboration et aux réaménagements psychiques. À partir du récit d’une expérience clinique avec une femme âgée et hospitalisée qui n’avait pu faire l’épreuve du deuil de son fils, il s’agit de déplier que, malgré les dispositifs lourds ou avec eux, l’aventure de l’inconscient reste possible, si la plasticité et la créativité du praticien et de la patiente ne sont pas soumises à trop rude épreuve.
Inverse Semigroups and Sheu's Groupoid for Odd Dimensional Quantum Spheres
Authors: Sundar S. 
Published: September 2011

Abstract.In this paper, we give a different proof of the fact that the odd dimensional quantum spheres are groupoid C*-algebras. We show that the C*-algebra is generated by an inverse semigroup T of partial isometries. We show that the groupoid 𝓖tight associated with the inverse semigroup T by Exel is exactly the same as the groupoid considered by Sheu.
An Immunohistochemical Panel to Differentiate Metastatic Breast Carcinoma to Skin From Primary Sweat Gland Carcinomas With a Review of the Literature
Authors: Rollins-Raval Marian , Chivukula Mamatha , Tseng George C , Jukic Drazen , Dabbs David J 
Published: September 2011

Context.—Approximately 25% of patients with breast cancer develop cutaneous metastases. Sweat gland carcinomas (SGCs) account for about 0.05% of all cutaneous neoplasms. Cutaneous metastases of breast carcinoma (CMBCs) (especially the ductal type) can be difficult to distinguish from SGCs. Treatment and prognoses for these 2 types of tumors differ radically, making accurate histologic diagnosis crucial. Although a few studies attempt to differentiate these entities employing immunohistochemical (IHC) studies (some of which we review here), to date, no panel of IHC stains exists, to our knowledge, to distinguish these entities.
Objective.—To devise a panel of IHC stains to distinguish CMBC from SGC.
Design.—Twelve cases of ductal CMBCs (11 not otherwise specified type, and 1 basal phenotype), 11 cases of SGCs (5 eccrine carcinomas, 3 porocarcinomas, and 3 microcystic adnexal carcinomas), 2 benign sweat gland neoplasm cases, and 2 primary breast cancer cases were retrieved and analyzed with the following IHC panel: mammaglobin, gross cystic disease fluid protein (GCDFP) 15, p63, basal cytokeratins (CK5, CK14, and CK17), androgen receptor, and PAX5.
Results.—The p63 was only weakly expressed in 1 of 12 CMBC cases (8.3%), whereas it was strongly expressed in 10 of 11 SGC cases (90.9%) (P &lt; .001). Basal cytokeratins demonstrated a similar immunoprofile in the SGC group, with 10 of 11 cases (90.9%) expressing all 3 markers, and a variable immunoprofile in the CMBC group with 0% (CK14) (P &lt; .001) to 16.7% (2 of 12 cases; CK5 and CK17) (P &lt; .001) expression. Mammaglobin was expressed in 8 of 12 cases (66.7%) of CMBC.
Conclusions.—Together, these 5 IHC stains were combined to make a panel that was 100% sensitive and 91% specific in distinguishing between CMBC and SGC.
A Study of Pathologic Risk Factors in Postchemoreduced, Enucleated Specimens of Advanced Retinoblastomas in a Developing Country
Authors: Suryawanshi Pallavi , Ramadwar Mukta , Dikshit Rajesh , Kane Shubhada V , Kurkure Purna , Banavali Shripad , Viswanathan Seethalakshmi 
Published: September 2011

Context.—Advanced cases of retinoblastoma are treated with chemoreduction followed by enucleation. Further adjuvant therapy is recommended in patients with known pathologic risk factors (PRFs).Objectives.—To determine the PRFs in enucleated specimens after chemoreduction and their association for adverse events of recurrence, metastasis, or death.Design.—This was a retrospective study of 77 enucleation specimens from patients treated between January 2000 and September 2008 with prior chemoreduction that were accessioned in the pathology department of a tertiary referral cancer center with an average follow-up of 24 months. Various PRFs were noted and their association with the development of an adverse event was recorded.Results.—Of 77 patients, (male to female ratio, 51∶26), the incidence of overall PRF was 51.9%, and retrolaminar optic nerve invasion (32.5%), optic nerve cut margin (12.9%), massive choroidal invasion (26%), scleral invasion (23.4%), vitreous seedings (44.2%), and anterior segment invasion (20.8%). Undifferentiated tumor (&gt;60%) was seen in 60.3% of cases (41 of 68 patients with differentiation available). Adverse event occurred in 18 of 72 patients with available follow-up (25%). Retrolaminar optic nerve invasion, optic nerve cut margin involvement, and scleral invasion were independent prognostic factors predicting the occurrence of an adverse event. Undifferentiated tumor (&gt;60%) was a significant risk factor in univariate analysis, which is the unique feature in this study.Conclusions.—Classic PRF with the addition of a predominant presence from the undifferentiated component were associated with adverse outcomes in retinoblastoma treated with anterior chemotherapy. The latter may represent chemoresistant clones and more intensive adjuvant chemotherapy may be warranted in these patients.