bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response of a manganite-based magnetic tunnel structure to microwave radiation
Authors: Volkov N V , Rautskiy M V , Eremin E V , Patrin G S , Kim P D , Lee C G 
Published: June 2012

Abstract
We demonstrate that a magnetic tunnel structure irradiated by microwaves can generate a typical voltage signal due to the rectification effect. We performed measurements in current-in-plane geometry when a current flows parallel to the interfaces in the structure. The value of the microwave-induced voltage strongly depends on the bias current and can be driven by a magnetic field. The rectification effect is discussed both in classical terms of nonlinearity of the current–voltage characteristics and within the mechanism involving the interplay between the spin-polarized current and the magnetization dynamics in the magnetic tunnel structure.
Long-range Rydberg–Rydberg interactions in calcium, strontium and ytterbium
Authors: Vaillant C L , Jones M P A , Potvliege R M 
Published: June 2012

Abstract
Long-range dipole–dipole and quadrupole–quadrupole interactions between pairs of Rydberg atoms are calculated perturbatively for calcium, strontium and ytterbium within the Coulomb approximation. Quantum defects, obtained by fitting existing laser spectroscopic data, are provided for all S, P, D and F series of strontium and for the 3P2 series of calcium. The results show qualitative differences with the alkali metal atoms, including isotropically attractive interactions of the strontium 1S0 states and a greater rarity of Förster resonances. Only two such resonances are identified, both in triplet series of strontium. The angular dependence of the long-range interaction is briefly discussed.
In vivo imaging of proteasome inhibition using a proteasome‐sensitive fluorescent reporter
Authors: Momose Isao , Tatsuda Daisuke , Ohba Shun‐ichi , Masuda Tohru , Ikeda Daishiro , Nomoto Akio 
Published: June 2012

A proteasome degrades numerous regulatory proteins that are critical for tumor growth and is therefore recognized as a promising anticancer target. Determining proteasome activity in the tumors of mice bearing xenografts is essential for the development of novel proteasome inhibitors. We developed a system for in vivo imaging of proteasome inhibition in the tumors of living mice, using a proteasome‐sensitive fluorescent reporter, ZsProSensor‐1. This reporter consists of a green fluorescent protein, ZsGreen, fused to mouse ornithine decarboxylase, which is degraded by the proteasome without being ubiquitinated. In stably transfected cells expressing ZsProSensor‐1, the fluorescent reporter was rapidly degraded under steady‐state conditions, whereas it was stabilized in the presence of proteasome inhibitors. Subcutaneous inoculation of the transfected cells into nude mice resulted in tumor formation. When the proteasome inhibitor bortezomib was intravenously administered to mice bearing these tumors, the ZsProSensor‐1 protein accumulated in the tumors and emitted a fluorescent signal in a dose‐dependent manner. Robust fluorescence was sustained for 3 days and then gradually decreased to baseline levels within 15 days. Intravenous administration of bortezomib also showed potent antitumor activity. In contrast, oral administration of bortezomib did not result in fluorescent protein accumulation in tumors or exhibit any antitumor activity. These results indicate that in vivo imaging using the ZsProSensor‐1 fluorescent protein can be used as an indicator of antitumor activity and will be a powerful tool for the development of novel proteasome inhibitors.
Randomized phase II study of three doses of oral TAS‐108 in postmenopausal patients with metastatic breast cancer
Authors: Inaji Hideo , Iwata Hiroji , Nakayama Takahiro , Yamamoto Naohito , Sato Yasuyuki , Tokuda Yutaka , Aogi Kenjiro , Saji Shigehira , Watanabe Kenichi , Saito Tsuyoshi , Yoshida Masayuki , Sato Nobuaki , Saeki Toshiaki , Takatsuka Yuichi , Kuranami Masaru , Yamashita Hiroko , Kikuchi Atsushi , Tabei Toshio , Ikeda Tadashi , Noguchi Shinzaburo 
Published: June 2012

This randomized phase II study was intended to identify the optimal dose of TAS‐108, a novel steroidal antiestrogen, for the treatment of breast cancer in postmenopausal Japanese women. The potential clinical effects of TAS‐108 on the uterus, bone, serum lipids, and hormones were also investigated. Postmenopausal women with hormone receptor‐positive metastatic breast cancer who had previously received one or two endocrine therapies were randomly assigned to one of the three possible dose levels of TAS‐108 (40, 80 or 120 mg/day). Oral TAS‐108 was given daily, and the efficacy and safety of the three doses were evaluated. A total of 97 patients (33, 32, and 32 in the 40‐, 80‐, and 120‐mg groups, respectively) were treated with TAS‐108. The clinical benefit rate was 30.3% for the 40‐mg, 25.0% for the 80‐mg, and 25.0% for the 120‐mg group. The 40‐mg group achieved the prespecified target threshold. TAS‐108 at all dose levels was well tolerated and appeared to have no harmful effects in terms of the variables examined in this study. We conclude that the optimal dose of TAS‐108 among the three doses is 40 mg, once daily, for further studies. JAPIC Clinical Trials Information number: Japic CTI – 121754.
Cancer‐testis antigen BORIS is a novel prognostic marker for patients with esophageal cancer
Authors: Okabayashi Koji , Fujita Tomonobu , Miyazaki Junichiro , Okada Tsutomu , Iwata Takashi , Hirao Nobumaru , Noji Shinobu , Tsukamoto Nobuo , Goshima Naoki , Hasegawa Hirotoshi , Takeuchi Hiroya , Ueda Masakazu , Kitagawa Yuko , Kawakami Yutaka 
Published: June 2012

Esophageal squamous cell cancer (ESCC) is one of the most common lethal tumors in the world, and development of new diagnostic and therapeutic methods is needed. In this study, cancer‐testis antigen, BORIS, was isolated by functional cDNA expression cloning using screening technique with serum IgG Abs from ESCC patients. BORIS was previously reported to show cancer‐testis antigen like expression, but its immunogenicity has remained unclear in cancer patients. BORIS was considered to be an immunogenic antigen capable of inducing IgG Abs in patients with various cancers, including four of 11 ESCC patients. Immunohistochemical study showed that the BORIS protein was expressed in 28 of 50 (56%) ESCC tissues. The BORIS expression was significantly associated with lymph node metastasis in ESCC patients with pT1 disease (P = 0.036). Furthermore, the patients with BORIS‐positive tumors had a poor overall survival (5‐year survival rate: BORIS‐negative 70.0% vs BORIS‐positive 29.9%, log‐rank P = 0.028) in Kaplan–Meier survival analysis and log‐rank test. Multivariate Cox proportional hazard model demonstrated that BORIS expression was an independent poor prognostic factor (hazard ratio = 4.158 [95% confidence interval 1.494–11.57], P = 0.006). Downregulation of BORIS with specific siRNAs resulted in decreased cell proliferation and invasion ability of ESCC cell lines. BORIS may be a useful biomarker for prognostic diagnosis of ESCC patients and a potential target for treatment including by BORIS‐specific immunotherapy and molecular target therapy.
Potentially curative treatment in patients with hepatocellular cancer—results from the liver cancer research network
Authors: Kanwal F. , Befeler A. , Chari R. S. , Marrero J. , Kahn J. , Afdhal N. , Morgan T. , Roberts L. , Mohanty S. R. , Schwartz J. , VanThiel D. , Li J. , Zeringue A. , Di'Bisceglie A. 
Published: June 2012

SummaryBackgroundThe extent to which potentially curative therapies are used in patients with hepatocellular cancer (HCC) and their related outcomes are unknown in the US.AimTo determine the rate and outcomes of potentially curative treatment in patients with HCC.MethodsEleven US centers followed patients with HCC between 2001 and 2007. We determined rates of liver transplantation, surgical resection, or tumour ablation during follow‐up, examined differences in adjusted survival of patients receiving these treatments, and determined the factors associated with receipt of potentially curative treatment.ResultsOf the 267 patients, 76 (28%) patients had early HCC, defined as Child A or B cirrhosis, with a solitary HCC or ≤3 nodules, each ≤3 cm. Of these, 53 (69.7%) received curative treatment. Thirty six percent of patients with non‐early HCC received curative treatment. Compared to patients with non‐early HCC who did not receive curative treatment, patients with early HCC and curative treatment had the best survival [hazard ratio, HR = 0.19 (95% CI, 0.08–0.42)] followed by patients with advanced HCC who received curative treatment [HR = 0.37 (95% CI, 0.22–0.64)]. Baseline performance status was significantly associated with receipt of curative treatment as well as survival after adjusting for demographics, clinical characteristics, and HCC stage.ConclusionsIn this multicenter database, most of the patients with early HCC received potentially curative treatment. However, only 28% of patients had early HCC. One‐third of patients with non‐early HCC also underwent curative therapy. Potentially curative treatment improved survival and this effect was seen in patients with early as well as non‐early HCC.
Ursodeoxycholic acid therapy in cystic fibrosis liver disease – a retrospective long‐term follow‐up case‐control study
Authors: Kappler M. , Espach C. , Schweiger‐Kabesch A. , Lang T. , Hartl D. , Hector A. , Glasmacher C. , Griese M. 
Published: June 2012

SummaryBackgroundThe prevention and treatment of liver disease associated with cystic fibrosis remain a significant unresolved problem.AimTo assess the long‐term effects of continuous ursodeoxycholic acid (UDCA) therapy in cystic fibrosis patients with constantly elevated serum liver enzymes.MethodsThe primary endpoint was the incidence of overt liver disease. Between 1989 and 2005, UDCA treatment was started in 98 subjects from a cohort of 382 cystic fibrosis patients. These subjects were compared with a historic control group of 352 subjects who attended our centre between 1975 and 1989 before UDCA became standard treatment. For the long‐term comparison of liver function and lung function tests, a group of 98 matched contemporary cystic fibrosis patients were compared with the 98 subjects treated with UDCA.ResultsOvert liver disease developed in only one of the 382 patients who was treated with UDCA for increased serum liver enzymes compared with nine patients in the historic control group (P < 0.05). Serum liver enzyme levels declined in most patients receiving UDCA treatment during the 17‐year follow‐up (87/98, P < 0.05). No difference was seen in lung function between subjects with cystic fibrosis‐related liver disease and the matched controls.ConclusionsRegular and systematic screening for liver involvement enables early introduction of UDCA therapy in affected cystic fibrosis patients, reduces the development of severe liver disease and leads to a significant and persistent improvement in serum liver tests, without impairing long‐term pulmonary outcome.
Identification of single nucleotide polymorphisms in the bovine follicle‐stimulating hormone receptor and effects of genotypes on superovulatory response traits
Authors: Cory Aron T. , Price Christopher A. , Lefebvre Rejean , Palin Marie‐France 
Published: June 2012

SummaryIn dairy cows, there is evidence that failure to respond to superovulation protocols is a heritable trait. In women, genotyping for the p.N680S single nucleotide polymorphism (SNP) in the follicle‐stimulating hormone receptor (FSHR) gene may help identify poor responders before ovarian stimulation is initiated. Our objectives were to identify SNPs in the coding region of the bovine FSHR gene and to investigate the effect of FSHR genotypes on superovulatory response in Holstein cattle. Sequencing of FSHR exons 1–10 revealed seven SNPs. Three were non‐synonymous mutations (c.337C>G, c.871A>G and c.1973C>G). SNP c.337C>G encodes for a proline‐to‐alanine (p.Pro113Ala) amino acid replacement in the extracellular ligand‐binding domain of the receptor. PCR‐RFLP analyses showed that homozygous GG Holstein cows present a higher percentage of viable embryos, whereas GG and CG animals have less unfertilised oocytes. SNP c.871A>G results in an isoleucine‐to‐valine (p.Ile291Val) modification, and homozygous AA animals present lower embryo yield after superovulatory treatments. SNP c.1973C>G corresponds to a threonine‐to‐serine (p.The658Ser) modification in the intracellular carboxyl‐terminal domain of the FSHR protein, and homozygous GG Holstein cows were associated with a lower embryo yield and a higher percentage of unfertilised oocytes. Our results suggest that specific alleles of the bovine FSHR gene are associated with variations in embryo yield and in the number of unfertilised oocytes.
Dynamic macroecology and the future for biodiversity
Authors: Mokany Karel , Harwood Thomas D. , Williams Kristen J. , Ferrier Simon 
Published: June 2012

AbstractReliable projections of climate‐change impacts on biodiversity are vital in formulating conservation and management strategies that best retain biodiversity into the future. While recent modelling has focussed largely on individual species, macroecology has the potential to add significant value to these efforts, by incorporating important community‐level constraints and processes. Here we show how a new dynamic macroecological approach can project climate‐change impacts collectively across all species in a diverse taxonomic group, overcoming shortfalls in our knowledge of biodiversity, while incorporating the key processes of dispersal and community assembly. Our approach applies a recently published technique (DynamicFOAM) to predict the present composition of every community, which form the initial conditions for a new metacommunity model (M‐SET) that projects changes in composition over time, under specified climate and habitat scenarios. Applying this approach at fine resolution to plant biodiversity in Tasmania (2,051 species; 1,157,587 communities), we project high average turnover in community composition from 2010 to 2100 (mean Sorensen's dissimilarity = 0.71 (±7.0 × 10−5)), with major reductions in species richness (32.9 (±0.02) species lost per community) and no plant species benefitting from climate change in the long term. We also demonstrate how our modelling approach can identify habitat likely to be of high value for retaining rare and poorly reserved species under climate change. Our analyses highlight the potential value of this dynamic macroecological approach, that incorporates key ecological processes in projecting climate change impacts for all species simultaneously and uses simple macroecological inputs that can be derived even for highly diverse and poorly studied taxa.
The (dis)placement of women in the IT workforce: an investigation of individual career values and organisational interventions
Authors: Quesenberry Jeria L , Trauth Eileen M 
Published: June 2012

AbstractThis paper reports on an investigation of career anchors of women in the information technology (IT) workforce that was directed at enhancing within‐gender theorising about career motivations of women in the IT profession. Our theoretical lens, the individual differences theory of gender and IT, enabled us to look more critically at how the effects of interventions are embedded in the range of women's career anchors that takes within‐gender variation into account. The analysis demonstrates that organisational interventions must be flexible enough to account for the diversity and variation among women. Further, the analysis shows that it is necessary to move away from ‘one size fits all’ organisational interventions that often reflect stereotypes about women in the IT workforce.
Factors influencing burden among non‐professional immigrant caregivers: a case–control study
Authors: Gallart Albert , Cruz Félix , Zabalegui Adelaida 
Published: June 2012

gallart a., cruz f. & zabalegui a. (2013) Factors influencing burden among non‐professional immigrant caregivers: a case–control study. Journal of Advanced Nursing69(3), 642–654. doi: 10.1111/j.1365‐2648.2012.06049.xAbstractAim.  To identify factors related to the burden that is experienced by untrained immigrant caregivers.Background.  There is growing concern about how to provide the care required by an ageing population. Although elder care has usually been provided by family members, this role is increasingly being fulfilled by immigrant caregivers with no formal training.Design.  Case–control study (burdened/non‐burdened according to the Zarit Burden Interview).Methods.  The study took place between May 2005–October 2009. Anonymous questionnaires were distributed to 110 immigrant caregivers and their corresponding older care recipients (n = 110), who were receiving care in their homes in Barcelona (Spain). The questionnaires included measures of burden, social support, quality of life and social integration, and items about the physical/psychological status of the care recipient and the nature of the care tasks. Two groups of immigrant caregivers were defined according to their scores on the Zarit Burden Interview: burdened (n = 55) and non‐burdened (n = 55).Results.  Burdened caregivers reported less social support, a poorer quality of life, and problems with social integration. Furthermore, 48% said that they lacked knowledge about the care task, while 44% had difficulty performing certain care tasks, which constitutes a risk situation.Conclusion.  Burden among untrained immigrant caregivers may be reduced by improving their social support systems and quality of life, thereby helping to ensure the availability of the caregiver services, which society increasingly needs.
Control in childbirth: a concept analysis and synthesis
Authors: Meyer Shaunette 
Published: June 2012

AbstractAim.  To report a concept analysis of control in childbirth.Background.  Control has a variety of definitions from a wide range of disciplines. In childbirth, however, the concept is more tenuous and depends on the context. It can be viewed in relationship to a woman’s body and labour progression, pain, environment and the ability to request her method of birth.Data sources.  Medline, CINAHL and PsycINFO databases were searched between 1970–2011 using the keywords, ‘control’, ‘childbirth’, ‘labour’ and ‘delivery’.Review methods.  Walker and Avant’s method of concept analysis was used for this review. In addition, cases were placed before defining attributes as recommended by Risjord.Results.  Four attributes of control were identified: decision‐making, access to information, personal security and physical functioning. Antecedents include pregnancy and expectations of the birth. Consequences include childbirth satisfaction, childbirth experience, emotional well‐being, fulfilment and the transition into motherhood. A model case, contrary case and borderline case are described.Conclusion.  Clarifying the definition of control in childbirth and defining its attributes can help inform women and maternity providers throughout the world. This analysis provides clarity to a previously tenuous concept and allows practitioners to better understand the critical relationship between control in childbirth and satisfaction with the childbirth experience. It also has the potential to affect perinatal outcomes and subsequently healthcare costs.
The appropriateness of, and compliance with, telephone triage decisions: a systematic review and narrative synthesis
Authors: Blank Lindsay , Coster Joanne , O’Cathain Alicia , Knowles Emma , Tosh Jonathan , Turner Janette , Nicholl Jon 
Published: June 2012

AbstractAim.  This paper is a report of the synthesis of evidence on the appropriateness of, and compliance with, telephone triage decisions.Background.  Telephone triage plays an important role in managing demand for health care. Important questions are whether triage decisions are appropriate and patients comply with them.Data sources.  CINAHL, Cochrane Clinical Trials Database, Medline, Embase, Web of Science, and Psyc Info were searched between 1980–June 2010.Design.  Literature review: Rapid Evidence Synthesis.Review methods.  The principles of rapid evidence assessment were followed.Results.  We identified 54 relevant papers: 26 papers reported appropriateness of triage decision, 26 papers reported compliance with triage decision, and 2 papers reported both. Nurses triaged calls in most of the studies (n = 49). Triage decisions rated as appropriate varied between 44–98% and compliance ranged from 56–98%. Variation could not be explained by type of service or method of assessing appropriateness. However, inconsistent definitions of appropriateness may explain some variation. Triage decisions to contact primary care may have lower compliance than decisions to contact emergency services or self care.Conclusion.  Telephone triage services can offer appropriate decisions and decisions that callers comply with. However, the association between the appropriateness of a decision and subsequent compliance requires further investigation and further consideration needs to be given to the minority of calls which are inappropriately managed. We suggest that a definition of appropriateness incorporating both accuracy and adequacy of triage decision should be encouraged.
Peer‐led diabetes self‐management programme for community‐dwelling older people in China: study protocol for a quasi‐experimental design
Authors: Shen Huixia , Edwards Helen , Courtney Mary , McDowell Jan , Wu Ming 
Published: June 2012

AbstractAim.  A protocol for a new peer‐led self‐management programme for community‐dwelling older people with diabetes in Shanghai, China.Background.  The increasing prevalence of type 2 diabetes poses major public health challenges. Appropriate education programmes could help people with diabetes to achieve self‐management and better health outcomes. Providing education programmes to the fast growing number of people with diabetes present a real challenge to Chinese healthcare system, which is strained for personnel and funding shortages. Empirical literature and expert opinions suggest that peer education programmes are promising.Design.  Quasi‐experimental.Methods.  This study is a non‐equivalent control group design (protocol approved in January, 2008). A total of 190 people, with 95 participants in each group, will be recruited from two different, but similar, communities. The programme, based on Social Cognitive Theory, will consist of basic diabetes instruction and social support and self‐efficacy enhancing group activities. Basic diabetes instruction sessions will be delivered by health professionals, whereas social support and self‐efficacy enhancing group activities will be led by peer leaders. Outcome variables include: self‐efficacy, social support, self‐management behaviours, depressive status, quality of life and healthcare utilization, which will be measured at baseline, 4 and 12 weeks.Discussion.  This theory‐based programme tailored to Chinese patients has potential for improving diabetes self‐management and subsequent health outcomes. In addition, the delivery mode, through involvement of peer leaders and existing community networks, is especially promising considering healthcare resource shortage in China.