bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feline lung–digit syndrome
Authors: Goldfinch Nick , Argyle David 
Published: February 2012

Practical relevance Feline ‘lung–digit syndrome’ describes an unusual pattern of metastasis that is seen with various types of primary lung tumours, particularly bronchial and bronchioalveolar adenocarcinoma. Tumour metastases are found at atypical sites, notably the distal phalanges of the limbs; the weightbearing digits are most frequently affected, and multiple-digit and multiple-limb involvement is common. Often primary lung tumours in cats are not detected because of clinical signs referable to the primary tumour; rather, many cases present with signs referable to distant metastases. Other sites of metastases from feline primary lung tumours include the skin, eyes, skeletal muscle and bone, as well as multiple thoracic and abdominal organs. These lesions are thought to arise from direct arterial embolisation from the tumour. Indeed tumour embolisation to the aortic trifurcation is possible. Patient group Primary lung neoplasms are uncommon in the cat. Older animals are most affected (mean age at presentation 12 years, range 2–20 years). There is no apparent sex or breed predilection. Clinical challenges Feline lung–digit syndrome presents a diagnostic challenge. Typically there is swelling and reddening of the digit, purulent discharge from the nail bed, and dysplasia or fixed exsheathment of the associated nail. While these signs might be suggestive of infection, this could be secondary to a digital metastatic lesion, particularly in a middle-aged or elderly cat. Radiographic evidence of extensive bony lysis of the distal phalanx, which can be trans-articular to the second phalanx, raises the index of clinical suspicion for metastasis of a primary pulmonary tumour. Thoracic radiography is warranted prior to any surgery or digital amputation as the prognosis is generally grave for cats with this syndrome, with a mean survival time of only 58 days after presentation. Evidence base This article reviews the previous literature and case reports of feline lung–digit syndrome and feline primary pulmonary neoplasia in general, discussing the course of this disease and the varying clinical presentations associated with different sites of metastasis.
Feline demodicosis
Authors: Beale Karin 
Published: February 2012

Practical relevance In cats, three species of demodex mites have been identified as causes of demodicosis, which may manifest as pruritus, miliary dermatitis and/or self-induced alopecia. The condition has been recognized in various countries but does seem to show regional preferences. Clinical challenges Diagnosis of feline demodicosis can be a challenge as mites are not always readily found within scrapings of the skin examined microscopically. One or more species of demodex mite may be involved in an infestation. Furthermore, the condition can be difficult to treat effectively. Audience This review is intended as a clinical update for veterinary surgeons in practice who rarely encounter demodicosis.
Lung lobe torsion in association with a chronic diaphragmatic hernia and haemorrhagic pleural effusion in a cat
Authors: Hambrook Lydia E , Kudnig Simon T 
Published: February 2012

Clinical summary This report describes torsion of the right cranial lung lobe in a cat with haemorrhagic pleural effusion and a chronic diaphragmatic hernia. Surgical treatment comprising lung lobectomy without de-rotation, and repair of the diaphragmatic defect, led to an uneventful recovery. Practical relevance Lung lobe torsion is a rare condition in cats. While spontaneous lung lobe torsions may occur, a frequent association with underlying thoracic disease has been recognised in cats. However, neither haemorrhagic pleural effusion nor diaphragmatic hernia have been previously described in cats with lung lobe torsions, although they have been documented in dogs and humans. In a cat with suspected lung lobe torsion, a thorough search for an underlying disease should be undertaken.
Synthesis and structure of magnesium hydroxide fluoride, Mg(OH)F: a topological intermediate between brucite- and rutile-type structures
Authors: Crichton W. A. , Parise J. B. , Müller H. , Breger J. , Marshall W. G. , Welch M. D. 
Published: February 2012

AbstractMagnesium hydroxyfluoride, Mg(OH)F, has been synthesized by a subcritical hydrothermal route from a 1:1 molar mixture of brucite, Mg(OH)2, and sellaite, MgF2 with a rutile type structure, in excess water. Using a combination of synchrotron X-ray and time-of-flight neutron powder diffraction, the structure of Mg(OH)F has been solved in the diaspore space group Pnma with a = 10.116(3), b = 4.6888(10) and c = 3.0794(7) Å at ambient conditions. The most intense diffraction lines are [dobs (hkl) Iobs]: 2.291 (211) 10, 4.253 (101) 7, 1.747 (212) 7, 2.229 (401) 6 and 1.480 (610) (4) Å, with the largest d-spacing at 5.058 Å. Sharp infrared stretching bands are located at 3679 and 3645 cm–1, with a broader band at 3535 cm–1. The topology of the structure is intermediate between that of the OH and F endmembers, being derived through notional shearing nearly normal to the sheets of octahedra of the CdI2/Mg(OH)2-type structure. Further similar shearing at an interval 1/2a would lead to a Cd(OH)F-type structure, which is also related to the rutile structure type. The observations and model presented here indicate a close correlation between the structural properties of the endmembers and Mg(OH)F.
Natrotitanite, ideally (Na0.5Y0.5)Ti(SiO4)O, a new mineral from the Verkhnee Espe deposit, Akjailyautas mountains, Eastern Kazakhstan district, Kazakhstan: description and crystal structure
Authors: Stepanov A. V. , Bekenova G. K. , Levin V. L. , Hawthorne F. C. 
Published: February 2012

AbstractNatrotitanite, ideally (Na0.5Y0.5)Ti(SiO4)O, is a new mineral from the Verkhnee Espe rare-element deposit at the northern exo-contact of the Akjailyautas granite massif in the northern part of the Tarbagatai mountain range, Eastern Kazakhstan. Both the mineral and the name have been approved by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association (IMA 2010-033). Star-shaped aggregates of small short prisms of yellow or yellowish white (Na,Y,REE)-bearing titanite rimmed by thin (∼2 μm) rims of natrotitanite are embedded in yttrium-bearing fluorite and replace narsarsukite. Associated minerals are microcline, albite, quartz, riebeckite, aegirine, biotite, astrophyllite, rutile, zircon and elpidite. Natrotitanite is milky white to yellowish grey, transparent to translucent, and has a white streak and a vitreous lustre. It shows pale orange cathodoluminescence but does not fluoresce under ultraviolet light. It shows no cleavage or parting, and is brittle; the calculated density is 3.833 g cm–3. The indices of refraction, measured with the Bloss spindle stage for the wavelength 590 nm using a gel filter, are α = 1.904, γ = 2.030, and these values are in accord with the mean refractive index, 1.988, calculated from the Gladstone-Dale relation. Natrotitanite is monoclinic,C2/c,a= 6.5691(2),b= 8.6869(3),c= 7.0924(2) Å, β = 114.1269(4)°,V= 369.4(2) Å3,Z= 4,a:b:c= 0.7562:1: 0.8164. The seven strongest lines in the X-ray powder diffraction pattern [in the orderd(Å),I, (hkl)] are as follows: 2.597, 10, (130); 3.248, 8, (11); 2.994, 6, (200); 1.641, 4, (330); 4.941, 3, (110); 1.498, 3, (400); 2.273, 3, (11). Chemical analysis by electron microprobe gave Nb2O51.28, SiO227.83, TiO235.00, SnO20.57, V2O30.36, Fe2O30.23, Y2O37.87, Ce2O30.83, Sm2O30.26, Gd2O30.46, Tb2O30.17, Dy2O32.45, Ho2O30.16, Er2O32.24, Tm2O30.50, Yb2O32.53, Nd2O30.35, Lu2O30.28, MnO 0.33, CaO 8.16, Na2O 5.55, F 1.52 O ≡ F –0.64, sum 98.71 wt.%. The resulting empirical formula is (Na0.39Ca0.32Y0.15Dy0.03Yb0.03Er0.03Ce0.01Ho0.01Tm0.01Gd0.01Nd0.01)Σ1.00(Ti0.95Nb0.02Sn0.01Fe3+0.01Mn0.01V0.01)Σ1.01Si1.01O4.00(O0.83F0.17), calculated on the basis of 3 cations per formula unit. The general formula is written as (Na,Ca,Y,REE)TiSiO4(O,F), and the endmember formula is (Na0.5Y0.5)Ti(SiO4)O.The crystal structure of a composite optically continuous crystal of natrotitanite and (Na, Y)-bearing titanite was mounted on a Bruker D8 three-circle diffractometer equipped with a rotating anode generator (MoKα radiation), a multi-layer optics incident-beam path and an APEX-II CCD detector. The crystal structure was refined in space groupC2/cto a finalR1index of 1.8%. Natrotitanite is isostructural with titanite, (Na + Y +REE) replacing Ca at theCasite in the titanite structure.
Rickturnerite, Pb7O4[Mg(OH)4](OH)Cl3, a complex new lead oxychloride mineral
Authors: Rumsey M. S. , Krivovichev S. V. , Siidra O. I. , Kirk C. A. , Stanley C. J. , Spratt J. 
Published: February 2012

AbstractRickturnerite, which has the ideal formula Pb7O4[Mg(OH)4](OH)Cl3, is a new mineral from Torr Works (Merehead) quarry, near the village of Cranmore in Somerset, United Kingdom. It occurs as pale emerald green to grey porous aggregates of disordered interwoven minute fibrous crystals with mereheadite, cerussite, calcite, aragonite, mimetite, hydrocerussite, “plumbonacrite” and an uncharacterized lead oxychloride, in cavities inside a manganite and pyrolusite pod. The crystals are typically less than 5 μm wide and 200 μm long, but they can reach 40 × 100 μm in cross-section and over 1 mm in length. The mineral is translucent with a vitreous lustre and each needle is brittle with an indistinct cleavage, breaking with a splintery fracture. The streak is white, the Mohs hardness ∼3 and the density calculated using the empirical formula 6.886 g cm–3. Electron microprobe analyses yielded PbO 87.7, MgO 1.79, CuO 0.14, Cl 6.62 wt.%; H2O was calculated on the basis of structural considerations as 2.27 wt.% totalling 97.02 wt.%. A charge-balanced formula, based on 12 anions, is Pb7.16Mg0.81Cu0.03Cl3.40H4.60O8.60. Rickturnerite is orthorhombic Pnma, with a = 5.8024(6), b = 22.717(2), c = 25.879(3) Å, V = 3411.2(6) Å3 and Z = 8. The diffraction pattern contains strong reflections that define a subcell with a = 5.8034(5), b = 11.3574(9), c = 12.939(2) Å, V = 852.9(6) Å3 (space group Pmm2 which is related to the real unit cell by the transformation matrix [100/020/002]), and weak reflections that correspond to doubled b and c parameters. Since the difference between the large and small cells is only in a number of split and low-occupancy positions in the disordered region of the structure we provide the description of the subcell structure. The five strongest lines in the X-ray powder diffraction pattern [listed as dobs (Å), Iobs, (hkl)] are as follows: 6.474, 100, (400); 3.233, 73, (107); 2.867, 57, (705); 5.636, 44, (011); 3.112, 31, (802). The crystal structure was solved by direct methods and refined using 1318 unique reflections to R1 = 0.063. The structure is composed of a fully ordered part consisting of double [O2Pb3]2+ chains of oxocentred [OPb4] tetrahedra extended along the b-axis, which together with Cl– ions form 2-dimensional blocks parallel to (001). In between these blocks, there is a disordered region containing ordered [Mg(OH)6]4– octahedra and low-occupancy Pb and OH sites with a slight degree of ordering; these produce the weak supercell reflections.
Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria
Authors: Wood Robin , Racow Kimberly , Bekker Linda-Gail , Middelkoop Keren , Vogt Monica , Kreiswirth Barry N , Lawn Stephen D 
Published: February 2012

Abstract

Background
Detection of lipoarabinomannan (LAM), a Mycobacterium tuberculosis (Mtb) cell wall antigen, is a potentially attractive diagnostic. However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing TB in diverse clinical populations. We therefore explored pathogen and host factors potentially impacting LAM detection.

Methods
LAM-ELISA assay testing, sputum smear and culture status, HIV status, CD4 cell count, proteinuria and TB outcomes were prospectively determined in adults diagnosed with TB and commencing TB treatment at a South African township TB clinic. Sputum TB isolates were characterised by IS61110-based restriction fragment length polymorphism (RFLP) and urines were tested for mycobacteriuria by Xpert® MTB/RIF assay.

Results
32/199 (16.1%) of patients tested LAM-ELISA positive. Median optical density and proportion testing LAM positive remained unchanged during 2 weeks of treatment and then declined over 24 weeks. LAM was associated with positive sputum smear and culture status, HIV infection and low CD4 cell counts but not proteinuria, RFLP strain or TB treatment outcome. The sensitivity of LAM for TB in HIV-infected patients with CD4 counts of ≥ 200, 100-199, 50-99, and < 50 cells/μl, was 15.2%, 32%, 42.9%, and 69.2% respectively. Mycobacteriuria was found in 15/32 (46.9%) of LAM positive patients and in none of the LAM negative controls.

Conclusions
Urinary LAM was related to host immune factors, was unrelated to Mtb strain and declined steadily after an initial 2 weeks of TB treatment. The strong association of urine LAM with mycobacteriuria is a new finding, indicating frequent TB involvement of the renal tract in advanced HIV infection.
Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii
Authors: Mout Rubul , Xu Zhi-Dong , Wolf Angela K H , Jo Davisson Vincent , Jarori Gotam K 
Published: February 2012

Abstract

Background
Geldanamycin (GA), a benzoquinone ansamycin antibiotic has been shown in vitro to possess anti-plasmodial activity. Pharmacological activity of this drug is attributed to its ability to inhibit PfHSP90. The parasite growth arrest has been shown to be due to drug-induced blockage of the transition from ring to trophozoite stage. To further evaluate the consequences of this pharmacodyamic feature, the anti-malarial activity of GA analogs with enhanced drug properties in a Plasmodium-infected animal model have been evaluated for their capacity to induce clearance of the parasite. In the process, a hypothesis was subsequently tested regarding the susceptibility of the cured animals to malaria reflected in an attenuated parasite load that may be evoked by a protective immune response in the host.

Methods
Six weeks old Swiss mice were infected with a lethal Plasmodium yoelii (17XL) strain. On appearance of clinical symptoms of malaria, these animals were treated with two different GA derivatives and the parasite load was monitored over 15-16 days. Drug-treated animals cured of the parasite were then re-challenged with a lethal dose of P. yoelii 17XL. Serum samples from GA cured mice that were re-challenged with P. yoelii 17XL were examined for the presence of antibodies against the parasite proteins using western blot analysis.

Results
Treatment of P. yoelii 17XL infected mice with GA derivatives showed slow recovery from clinical symptoms of the disease. Blood smears from drug treated mice indicated a dominance of ring stage parasites when compared to controls. Although, P. yoelii preferentially invades normocytes (mature rbcs), in drug-treated animals there was an increased invasion of reticulocytes. Cured animals exhibited robust protection against subsequent infection and serum samples from these animals showed antibodies against a vast majority of parasite proteins.

Conclusions
Treatment with GA derivatives blocked the transition from ring to trophozoite stage presumably by the inhibition of HSP90 associated functions. Persistence of parasite in ring stage leads to robust humoral immune response as well as a shift in invasion specificity from normocytes to reticulocyte. It is likely that the treatment with the water-soluble GA derivative creates an attenuated state (less virulent with altered invasion specificity) that persists in the host system, allowing it to mount a robust immune response.
PDCD6 is an independent predictor of progression free survival in epithelial ovarian cancer
Authors: Su Dan , Xu Haiyan , Feng Jianguo , Gao Yun , Gu Linhui , Ying Lisha , Katsaros Dionyssios , Yu Herbert , Xu Shenhua , Qi Ming 
Published: February 2012

Abstract

Background
Programmed cell death 6 (PDCD6) beside its known proapoptotic functions may be a player in survival pathways in cancer. The purpose of this study is to further explore the roles of PDCD6 in epithelial ovarian cancer.

Methods
Lentiviral vector with shRNA for PDCD6 was used to investigate the effects of PDCD6 knockdown on cell growth, cell cycle, apoptosis and motility in ovarian cancer cells. Two hundred twelve epithelial ovarian cancer tissues were analyzed for mRNA expression of PDCD6 using RT-PCR. Associations of its expression with clinical pathological factors, progression free and overall survival were evaluated.

Results
PDCD6 is highly expressed in metastatic ovarian cancer cells and positively regulates cell migration and invasion. Significantly, the level of PDCD6 expression in epithelial ovarian cancer correlates with clinical progression. Patients with medium or high levels of PDCD6 mRNA were at higher risk for disease progression, compared to those with low levels (HR, 1.29; P = 0.024 for medium levels; and HR, 1.57; P = 0.045 for high levels) after adjusting for age, disease stage, tumor grade, histologic type and residual tumor size. Kaplan-Meier survival analysis demonstrated similar results. However, no association was found between PDCD6 expression and overall survival.

Conclusions
PDCD6 seems to play an important role in ovarian cancer progression and it may be an independent predictor of progression free survival in epithelial ovarian cancer. Further studies are needed to more completely elucidate the molecular mechanisms of PDCD6 involve in ovarian cancer progression.
Strong convergence of relaxed hybrid steepest-descent methods for triple hierarchical constrained optimization
Authors: Zeng L C , Wong M M , Yao J C 
Published: February 2012

Abstract
Up to now, a large number of practical problems such as signal processing and network resource allocation have been formulated as the monotone variational inequality over the fixed point set of a nonexpansive mapping, and iterative algorithms for solving these problems have been proposed. The purpose of this article is to investigate a monotone variational inequality with variational inequality constraint over the fixed point set of one or finitely many nonexpansive mappings, which is called the triple-hierarchical constrained optimization. Two relaxed hybrid steepest-descent algorithms for solving the triple-hierarchical constrained optimization are proposed. Strong convergence for them is proven. Applications of these results to constrained generalized pseudoinverse are included.

AMS Subject Classifications: 49J40; 65K05; 47H09.
Fibonacci sequences in groupoids
Authors: Han Jeong Soon , Kim Hee Sik , Neggers Joseph 
Published: February 2012

Abstract
In this article, we consider several properties of Fibonacci sequences in arbitrary groupoids (i.e., binary systems). Such sequences can be defined in a left-hand way and a right-hand way. Thus, it becomes a question of interest to decide when these two ways are equivalent, i.e., when they produce the same sequence for the same inputs. The problem has a simple solution when the groupoid is flexible. The Fibonacci sequences for several groupoids and for the class of groups as special cases are also discussed.

2000 Mathematics Subject Classification: 20N02; 11B39.
ABA signal in rice under stress conditions
Authors: Ye Nenghui , Jia Liguo , Zhang Jianhua 
Published: February 2012

AbstractEver since its discovery, abscisic acid (ABA) has been intensively studied due to its versatile functions in plant developmental and physiological processes. Many signaling details of ABA have been well elucidated and reviewed. The identification of ABA receptors is a great breakthrough in the field of ABA study, whereas the discovery of ABA transporter has changed our concept that ABA is delivered solely by passive transport. The intensity of ABA signaling pathway is well known to be controlled by multi-regulators. Nonetheless, the interaction and coordination among ABA biosynthesis, catabolism, conjugation and transportation are seldom discussed. Here, we summarize the biological functions of ABA in response to different stresses, especially the roles of ABA in plant defense to pathogen attack, and discuss the possible relationships of these determinants in controlling the specificity and intensity of ABA signaling pathway in the rice.
Ultimately Simple One-pot Synthesis of Spherical Mesoporous TiO2 Nanoparticles in Supercritical Methanol
Authors: Wang Pengyu , Kobiro Kazuya 
Published: February 2012

Abstract
Mesoporous TiO2 nanoparticles were synthesized using different carboxylic acids as organic additives in a very short reaction time (10 min) in supercritical methanol. Solid spherical mesoporous TiO2 nanoparticles were obtained using phthalic acid, whereas hollow spherical mesoporous TiO2 nanoparticles were obtained using formic acid.
Polymer-free Organic–Inorganic Hybrid Materials with High Refractive Indices and Thermoplastic Properties
Authors: Oda Shinya , Uchiyama Hiroaki , Kozuka Hiromitsu 
Published: February 2012

Abstract
We prepared a new class of organic–inorganic hybrid materials with high refractive indices and thermoplasticity. Titanium and zirconium alkoxides were hydrolyzed in the presence of β-diketones of high melting and boiling points, followed by concentration and heating over 100 °C. Transparent, glass-like solid materials were obtained, exhibiting softening or melting behavior on heating in spite of the absence of organic polymers. The refractive indices of the thermoplastic hybrid materials were as high as 1.7.
Arthroscopy of the hip for paediatric and adolescent disorders
Authors: Jayakumar P. , Ramachandran M. , Youm T. , Achan P. 
Published: February 2012

Hip arthroscopy is particularly attractive in children as it confers advantages over arthrotomy or open surgery, such as shorter recovery time and earlier return to activity. Developments in surgical technique and arthroscopic instrumentation have enabled extension of arthroscopy of the hip to this age group. Potential challenges in paediatric and adolescent hip arthroscopy include variability in size, normal developmental change from childhood to adolescence, and conditions specific to children and adolescents and their various consequences. Treatable disorders include the sequelae of traumatic and sports-related hip joint injuries, Legg–Calve–Perthes’ disease and slipped capital femoral epiphysis, and the arthritic and septic hip. Intra-articular abnormalities are rarely isolated and are often associated with underlying morphological changes.This review presents the current concepts of hip arthroscopy in the paediatric and adolescent patient, covering clinical assessment and investigation, indications and results of the experience to date, as well as technical challenges and future directions.