bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of predictors of recurrent acute cardiovascular events in patients with acute coronary syndrome
Authors: Usova E. I. , Malishevsky L. M. , Alieva A. S. , Makarova T. А. , Alieva M. S. , Yakovlev A. N. , Conradi A. O. 
Published: June 2024

Aim. To assess the prevalence of traditional risk factors and analyze the predictors of recurrent cardiovascular events in patients with acute coronary syndrome (ACS).Material and methods. A total of 482 patients with ACS were included. The follow-up lasted three years. The composite endpoint (CE) included recurrent unstable angina, nonfatal myocardial infarction, repeated percutaneous coronary intervention (PCI), nonfatal ischemic stroke, hospitalization for decompensated heart failure, and cardiovascular death.Results. A high prevalence of traditional risk factors was revealed (dyslipidemia — 467 (96,9%), hypertension — 464 (96,3%), consumption of junk food — 450 (93,4%), sedentary lifestyle — 416 (86,3%)). During the three-year follow-up period, 90 patients had CE. Compared with patients without CE (n=392), patients with CE were significantly more likely to have a long-term CAD (69 (76,7%) vs 241 (61,5%), p=0,007), ACS accompanied by shortness of breath (50 (55,6%) vs 160 (40,9%), p=0,013); they had previously undergone myocardial revascularization (38 (42,2%) vs 116 (29,6%), p=0,024), often by PCI (36 (40,0%) vs 100 (25,5%), p=0,009), especially in the left main coronary artery (LMCA) (6 (6,7%) vs 3 (0,8%), p=0,002); they were more likely to develop in-hospital acute left ventricular failure (11 (12,2%) vs 18 (4,6%), p=0,012), had a lower hemoglobin level and hematocrit (p<0,05 for all); they more often required intensification of lipid-lowering therapy (86 (100%) vs 334 (85,2%), p=0,002), compliance with which was lower (6 (6,7%) vs 105 (26,8%), p<0,001) than in patients without CE. Previous intervention on the left coronary artery, non-compliance with lipidlowering therapy, hematocrit level 3 months and hemoglobin level 1 year after ACS were predictors of recurrent events. The combination of surgery on left coronary artery and non-compliance with lipid-lowering therapy demonstrated significantly less freedom from CE compared with other patients (77,4% vs 94,6%, p<0,001).Conclusion. A high prevalence of traditional risk factors in the population of patients with ACS was revealed, and potential predictors of recurrent cardiovascular events were identified.
Results of the Russian Society of Cardiology survey "Chronic heart failure. Unsolved issues"
Authors: Irtyuga O. B. , Nedogoda S. V. , Sitnikova M.Yu. М. Yu. , Galyavich А. S. , Villevalde S. V. , Nedoshivin A. O. , Konradi A. O. , Shlyakhto E. V. 
Published: June 2024

Aim. To analyze the readiness of the professional medical community for changes in the classification and implementation of novel approaches to heart failure (HF) treatment based on an online survey.Material and methods. Anonymous online survey of physicians on the official website of the Russian Society of Cardiology (www.scardio.ru) "Chronic heart failure. Unsolved issues" was held from September 30 to October 4, 2023. The survey involved 1015 doctors with an average length of work >10 years, mainly cardiologists (n=810, 83,2%).Results. The majority (n=591, 58,2%) of respondents considered it necessary to identify the HF prestage in the classification, similar to prediabetes or prehypertension, while only 2,2% (n=22) of respondents did not consider it necessary to indicate the HF risk in the classification. Simplifying the HF classification based on the left ventricular ejection fraction (LVEF) values with the identification of only two gradations of LVEF <50% and LVEF ³50% was supported by 60,3% (n=612) of specialists.The majority (80,8%) of respondents supported increasing the time of admission of a patient with HF to 30 minutes to ensure the healthcare quality. According to the survey, only 32% of respondents have the ability to determine the brain natriuretic peptide level in patients with HF without restrictions, which indicates insufficient material security for the implementation of clinical guidelines in practice. Quadruple therapy is prescribed to every patient with HF by only 37% of respondents who took part in the survey, which may indicate clinical inertia regarding following the guidelines.Conclusion. In general, the survey demonstrated high awareness of physicians about the problem of HF and readiness to assess the risk and diagnose HF at preclinical stages, as well as a positive attitude towards changing the classification.
Angiotensin II–Type-1a Receptor and Renal K+ Wasting during Overnight Low-Na+ Intake
Authors: Duan Xin-Peng , Zheng Jun-Ya , Xiao Yu , Zhang Cheng-Biao , Lin Dao-Hong , Wang Wen-Hui 
Published: June 2024

Key Points

Angiotensin II–type-1a-receptor in the distal convoluted tubule (DCT) plays a role in regulating sodium transport in the DCT.Angiotensin II–type-1a-receptor in the DCT plays a role in maintaining potassium homeostasis during sodium restriction.

Background
Chronic angiotensin II perfusion stimulates Kir4.1/Kir5.1 of the distal convoluted tubule (DCT) via angiotensin II–type-1a-receptor (AT1aR), and low‐sodium intake also stimulates Kir4.1/Kir5.1. However, the role of AT1aR in mediating the effect of low salt on Kir4.1/Kir5.1 is not explored.

Methods
We used the patch-clamp technique to examine Kir4.1/Kir5.1 activity of the DCT, employed immunoblotting to examine Na-Cl cotransporter (NCC) expression/activity, and used the in vivo perfusion technique to measure renal Na+ and renal K+ excretion in control, kidney tubule–specific–AT1aR-knockout mice (Ks-AT1aR-KO) and DCT-specific–AT1aR-knockout mice (DCT-AT1aR-KO).

Results
Angiotensin II acutely stimulated the 40-pS-K+ channel (Kir4.1/Kir5.1-heterotetramer) and increased whole-cell Kir4.1/Kir5.1-mediated K+ currents and the negativity of DCT membrane potential only in late DCT2 but not in early DCT. Acute angiotensin II increased thiazide-induced renal Na+ excretion (ENa). The effect of angiotensin II on Kir4.1/Kir5.1 and hydrochlorothiazide-induced ENa was absent in Ks-AT1aR-KO mice. Overnight low-salt intake stimulated the expression of Agtr1a mRNA in DCT, increased whole-cell Kir4.1/Kir5.1-mediated K+ currents in late DCT, hyperpolarized late DCT membrane, augmented the expression of phosphor-Na-Cl-cotransporter, and enhanced thiazide-induced renal-ENa in the control mice. However, the effect of overnight low-salt intake on Kir4.1/Kir5.1 activity, DCT membrane potential, and NCC activity/expression was abolished in DCT-AT1aR-KO or Ks-AT1aR-KO mice. Overnight low-salt intake had no effect on baseline renal K+ excretion (EK) and plasma K+ concentrations in the control mice, but it increased baseline renal-EK and decreased plasma K+ concentrations in DCT-AT1aR-KO or in Ks-AT1aR-KO mice.

Conclusions
Acute angiotensin II or overnight low-salt intake stimulated Kir4.1/Kir5.1 in late DCT, and AT1aR was responsible for acute angiotensin II or overnight low-salt intake–induced stimulation of Kir4.1/Kir5.1 and NCC. AT1aR of the DCT plays a role in maintaining adequate baseline renal-EK and plasma K+ concentrations during overnight low-salt intake.
О смене технологических укладов и трансформации права
Authors: Arzamasov Yury , Nazaykinskaya Varvara 
Published: June 2024

В рецензии анализируется содержание монографии «Смена технологических укладов и правовое развитие России» (М.: Норма, 2021. 184 с.), авторы которой — Д.А. Пашенцев, М.В. Залоило, А.А. Дорская. В рецензируемой работе исследован процесс смены технологических укладов и связанные с этим трансформации в сфере российского права и законодательства. Выявлены закономерности и определена специфика каждого из технологических укладов. На основании анализа разнообразного теоретического и эмпирического материала авторы определили важные перспективы перехода к новому технологическому циклу, возможные риски и проблемы, связанные с этим. Комплексный подход, примененный авторами, изучение ими различных факторов при характеристике изменений, происходящих в правовой системе, делают рецензируемую монографию интересной и полезной широкому кругу читателей.Для цитирования: АрзамасовЮ.Г., НазайкинскаяВ.А. О смене технологических укладов и трансформации права // Право. Журнал Высшей школы экономики. 2022. № 3. С. 278–286. DOI:10.17323/2072-8166.2022.3.278.286.
Современные модели административнопроцессуального регулирования: опыт сравнительно-правового исследования
Authors: Zelentsov Aleksandr , Yastrebov Oleg 
Published: June 2024

В статье рассматриваются подходы к пониманию административного процесса и его структуры в России и ряде зарубежных стран. Выявляется возрастание в российской административно-процессуальной науке интереса к разработке «синтезирующей» общей теории административного процесса, в том числе на основе интегративной методологии. В этом контексте раскрывается специфика подходов к его пониманию в зарубежных странах и концептуализируются две основные кодификационные модели административно-процессуального регулирования: модель раздельной кодификации, предполагающая регулирование административных процедур и административного судебного процесса (административного судопроизводства) в двух самостоятельных актах, и модель общей (единой) кодификации, которая характеризуется объединением этих видов административного процесса в одном кодифицирующем акте. Особенное внимание уделяется реализации модели общей кодификации административных процедур и административного судопроизводства. В рамках этой модели административный процесс отождествляется исключительно с административным судопроизводством. В свою очередь, возрастает тенденция к использованию модели общей кодификации, объединяющей в одном кодексе принципы и нормы, которые регламентируют и административные процедуры, и административное судопроизводство. Выявляются особенности юридической техники при проведении такой кодификации,анализируется уровень системной целостности этих единых кодифицирующих актов с позиций интегративной методологии общей теории административного процесса. Логика исследования и практический интерес предопределили необходимость внимательного изучения опыта реализации модели единой кодификации в государствах постсоветского пространства и определения места производства по делам об административных правонарушениях в национальных административно-процессуальных системах. Исследование опыта использования моделей единой кодификации и его осмысление создают дополнительные стимулы и предпосылки для развития интегративной концепции административного процесса, понимаемого как целостное явление в единстве его юрисдикционной и не юрисдикционной (позитивной) составляющих. В статье раскрываются особенности применения интегративной методологии к пониманию и интерпретации административного процесса в российской науке и проблемные вопросы построения на ее основе общей теории административного процесса.Дляцитирования: ЗеленцовА.Б., Ястребов О.А. Современные модели административно-процессуального регулирования: опыт сравнительно-правового исследования // Право. Журнал Высшей школы экономики. 2022. № 3. С. 96–130. DOI:10.17323/2072- 8166.2022.3.96.130.
Interstitial electrical stimulation for middle-aged, and elderly adults with early stages of knee osteoarthritis
Authors: Burmatov N. A. , Sergeev K. S. , Luneva S. N. , Gerasimov A. A. , Kopylov S. A. , Spiridonova N. A. 
Published: June 2024

Introduction The adequate, pathogenetically substantiated pain management is essential for treatment of early stages of deforming osteoarthritis of the knee joint. There is a need to explore the effectiveness and mechanisms of modern methods of electrical therapy and their impact on the quality of life due to close cause-and-effect relationship between the pain, inflammatory and destructive components of osteoarthritis (OA) as one of the most common conditions.The objective was to evaluate the effect of interstitial electrical stimulation (IES) as a monotherapy in the course of conservative treatment of early stages of gonarthrosis based on clinical and biochemical findings.Materials and methods Radiographic findings, skin electrometry (objective parameters of pain intensity), limb weight-bearing capacity, biochemical parameters of connective tissue matrix degradation in blood serum and 24-hour urine samples, and treatment satisfaction were explored in 43 patients. Patients who received a course of IES were assigned to the treatment group (n = 22) and patients who received standard treatment without IES constituted the control group (n = 21).Results Electrometric analysis showed a higher effectiveness of pain relief in the treatment group compared to the controls with asymmetry coefficient measuring 3.2 ± 0.31 versus 1.9 ± 0.4 at p > 0.05. The weight‑bearing scored 3.59 ± 0.34 versus 3.26 ± 0.2 at p > 0.05. The treatment group showed shorter treatment length with 13.21 ± 1.2 days versus 18.3 ± 1.2 days in the control group at p > 0.05 and a higher degree of satisfaction with outcomes scored 96.2 ± 2.59 in the treatment group versus 86.2 ± 3.17 in the control group. A statistically significant difference (p > 0.05) was established in the levels of free and total hydroxyproline characterizing the different intensity of collagen breakdown in the groups at the end of treatment.Discussion The IES used as an analgesic and anti-inflammatory therapy was shown to be highly effective with changes in the hydroxyproline level in the media suggesting a chondroprotective effect. The analysis and comparison of objective parameters demonstrated high effectiveness of IES in the treatment of early stages of gonarthrosis in middle-aged and elderly adults.Conclusion The IES used for treatment of early stages of gonarthrosis helps pain reducing the intensity of collagen destruction and improving weight-bearing.
Total ankle arthroplasty in an adolescent who suffered hematogenous osteomyelitis of tibia
Authors: Zorin V. I. , Berdes A. I. , Glukhov D. A. , Mushkin A. Yu. 
Published: June 2024

Introduction Acute hematogenous osteomyelitis can persist as chronic infection in pediatric patients due to delayed diagnosis and treatment. An extended bone defect of the limb caused by osteomyelitic destruction is a rare clinical scenario in pediatric surgery. Metaepiphyseal and articular involvement suggests specific and long-term treatment with a high risk of disability.The objective was to report a clinical case of a teenager who suffered chronic hematogenous osteomyelitis of the tibial bones and raise awareness of primary diagnosis and treatment.Material and methods A clinical case of a teenager treated for extensive destruction of the tibial bones caused by chronic hematogenous osteomyelitis is reported. Clinical and functional evaluation of the effectiveness was produced at the stages of treatment.Results A positive functional result was achieved due to staged surgical treatment including radical debridement of the chronic infection nidus followed by total ankle arthroplasty.Discussion Acute hematogenous osteomyelitis persisting as chronic infection could be caused either by a wait-and-see strategy when the patient first sought medical help or a long-term follow-up. There is no consensus on the use of reconstruction or replacement of large long bone defects extended to the joints caused by chronic infection. Staged treatment including total joint replacement with custom-made endoprosthesis can be one of the options.Conclusion Staged surgical treatment including radical debridement followed by delayed total joint replacement with custom-made endoprosthesis provided satisfactory functionality for the limb without signs of infectious and inflammatory activity at a follow-up period of more than a year.
Comparative analysis of neural network and ARIMA models for time series forecasting: evaluation of efficiency and applicability
Authors: Раскатова М.В. , Терелецкова Е.Е. , Сало А.А. , Челышев Э.А. 
Published: June 2024

В статье проводится сравнительный анализ нейросетевых и ARIMA-моделей для прогнозирования временных рядов. Оценивается их эффективность и применимость в различных сценариях прогнозирования. Нейросетевые модели, такие как многослойные персептроны и сверточные нейронные сети, обладают высокой гибкостью и способностью улавливать сложные нелинейные взаимосвязи в данных. ARIMA-модели (авторегрессионные интегрированные скользящие средние) предназначены для прогнозирования стационарных временных рядов и часто используются для прогнозирования экономических и финансовых данных. В статье описаны теоретические понятия ARIMA-модели и нейросетевой модели, указаны виды нейросетевых моделей: персептрон, многослойный персептрон, рекуррентные нейронные сети, сверточные нейронные сети и глубокие нейронные сети. Также указаны иные модели прогнозирования: SARIMA и SARIMAX. Для сравнения этих двух моделей применена программа STATISTICA. Также в статье оценена точность двух моделей для различных сценариев прогнозирования с помощью ошибки MAPE.
This article provides a comparative analysis of neural network and ARIMA models for time series forecasting. Their effectiveness and applicability in various forecasting scenarios are assessed. Neural network models such as multilayer perceptrons and convolutional neural networks are highly flexible and capable of capturing complex nonlinear relationships in data. ARIMA (Autoregressive Integrated Moving Average) models are designed for forecasting stationary time series and are often used to forecast economic and financial data. The article describes the theoretical concepts of the ARIMA model and the neural network model, and indicates the types of neural network models: perceptron, multilayer perceptron, recurrent neural networks, convolutional neural networks and deep neural networks. Other forecasting models are also indicated: SARIMA and SARIMAX. To compare these two models, the STATISTICA program was used. Also, this paper evaluates the accuracy of two models for different forecasting scenarios using the MAPE error.
Analysis of the prospects of using the FPGA platform for the implementation of machine learning algorithms for the purpose of high-speed processing of information from the video stream
Authors: Смирнов А.В. , Власов Е.Е. , Пистун Е.Н. 
Published: June 2024

Статья посвящена исследованию перспективы применения платформы программируемых логических интегральных схем (ПЛИС) для реализации алгоритмов машинного обучения с целью высокоскоростной обработки информации из видеопотока. Обосновывается актуальность и значимость темы исследования. Дается краткое обоснование роли и значимости развития применения платформы ПЛИС для реализации алгоритмов машинного обучения. Постулируется, что в настоящее время ПЛИС в среднем более производительна в общих задачах, чем процессор специального назначения. Когда производительность процессора недостаточна и нет готовых схем для решения проблемы, используются ПЛИС, особенно когда речь идет о 100-процентной гарантированной обработке и гарантированной задержке. В отличие от мощного процессора, мощная ПЛИС не требует дополнительной памяти, потребляет меньше энергии и может быть реализована в компактном устройстве. ПЛИС более производительна, но менее гибка с точки зрения реализации некоторых задач. В то же время сфера применения технологии довольно широка. Анализ научной литературы позволил сделать заключение о ее эффективности в различных областях.
The article addresses the prospects of using the FPGA platform for the implementation of machine learning algorithms for the purpose of high-speed processing of information from a video stream. The authors substantiate the relevance and significance of the research topic. A brief justification of the role and significance of the development of the FPGA platform for the implementation of machine learning algorithms is given. It is stated that at present the FPGA is on average more productive in general tasks than a special-purpose processor. When the processor performance is insufficient and there are no ready-made circuits to solve the problem, FPGAs are used. Especially when it comes to 100-percent guaranteed processing and guaranteed latency. Unlike a powerful processor, a powerful FPGA does not require additional memory, consumes less energy and can be implemented in a compact device. FPGA is more productive, but less flexible in terms of implementing some tasks. At the same time, the scope of the technology is quite wide. The analysis of the scientific literature allowed us to conclude about its effectiveness in various fields.
SOCIABILIDADES E REFERÊNCIAS CULTURAIS EM SEDE DE SANTA LUZIA
Authors: Bastos Lis Katia Cunha 
Published: June 2024

Com este recorte da pesquisa de mestrado, Festa e Velório em Sede de Santa Luzia; imagem e imaginário de 1981 a 2022, pretendo demonstrar a relevância social e simbólica que o espaço de devoção e proteção, que é a Associação Beneficente de Santa Luzia - Classe Operária (Sede), tem para a comunidade. Para tanto, apresento análise de dois itens das entrevistas do Inventário Nacional das Referências Culturais, anexado ao dossiê da candidatura da cidade de Goiás como patrimônio mundial cultural da humanidade para a Organização das Nações Unidas para a Educação, a Ciência e a Cultura (UNESCO), especialmente a entrevista de Tia Fia, mulher preta, que foi presidente desta associação na década de 1990. Proponho, além disso, tecer algumas reflexões sobre o que liga as irmandades de Nossa Senhora do Rosário dos Homens Pretos e de Santa Luzia e a Sede de Santa Luzia.
EPISTEMICÍDIO À VALORIZAÇÃO HISTORIOGRÁFICA NEGRA: LUIZ GAMA E LUIZA MAHIN
Authors: Guimarães Vinícius Ferreira , Marinho Thais Alves 
Published: June 2024

O projeto de pesquisa contorna a vida e historia de Luiz Gama, abolicionista que viveu no século XIX e que teve sua vida e historia alvo de estudos e mistificações, até a valorização de sua figura, mediante a mobilização de movimentos negro que forem de relutar quanto as representações do negro, onde em momento fora não brasileiro e exótico e em outro brasileiro e simbolismo da nação brasileira. E para chegarmos a essas conclusões utilizamos como método a analise de discurso mediante a revisão biográfica e analise do filme Dr. Gama no intuito de identificarmos esses discurso exotizantes e problemáticos quanto a persona de Luiz Gama e sua mãe (Luiza Mahin).
ACERVO QUILOMBOLA MARIA ENILDA MARQUES BOEIRA: CONFLUÊNCIAS NA EDUCAÇÃO DAS RELAÇÕES ÉTNICO-RACIAIS
Authors: Meinerz Carla Beatriz , Fontoura Laryssa Flores 
Published: June 2024

Objetiva-se narrar e analisar o processo de criação e organização do acervo da professora quilombola Maria Enilda Marques Boeira, desde 2023 guardado no Arquivo da Faculdade de Educação da Universidade Federal do Rio Grande do Sul, como resultado da investigação intitulada “Faculdade de Educação e Movimento Negro Educador”. A professora quilombola pertence à Comunidade do Limoeiro, localizada em Bacupari/Palmares do Sul/RS, e a iniciativa do acervo surgiu da relação estabelecida em pesquisa com a Professora Doutora Petronilha Beatriz Gonçalves e Silva, na qualidade de pesquisadora do território quilombola e intelectual ativista do Movimento Negro Educador (GOMES, 2017). A metodologia é de abordagem qualitativa, com uso de aproximação por visitas aos territórios, entrevistas, organização e análise documental. Os resultados parciais apontam a potência das ações de confluências de saberes entre uma pesquisadora da educação superior e uma professora da educação básica, ambas forjadas na docência e na pesquisa comprometida com a emancipação das pessoas negras no Rio Grande do Sul, através do combate ao racismo e à supremacia branca. Utiliza-se a categoria afeto, a partir das leituras de bell hooks, como chave para pensar tais registros.