bluuebunny/crossref_metadata_2025_split huggingface dataset:
In silico screening of pomegranate (Punica granatum) and celery (Apium graveolens) metabolites for potential anti-type 2 diabetes activity
Authors: Auli Winni Nur , Aziz Syaikhul , Karim Dewi Damayanti Abdul , Evanggeulista Arnanda , Jannah Aryn Fatkhul , Mendrofa Alexander Yoel Harazachi 
Published: May 2024

Background: Alpha (α)-amylase is a popular pharmacological target for controlling postprandial blood glucose levels. The exploration of natural ingredients for drug development is particularly promising. Notably, pomegranate (Punica granatum) and celery (Apium graveolens) are rich in phenols and flavonoids, making them potential candidates for anti-type 2 diabetes treatments.
Objective: This study aims to identify the most promising derivatives from pomegranate and celery using a combined metabolomic and in silico approach.
Methods: The study began by identifying metabolites from the KnapSack database, selecting based on primary and secondary metabolites also selecting them based on their pharmacokinetic profile. The selected metabolites were then docked with alpha-amylase (PDB ID: 2QV4). Furthermore, the interactions were analyzed using Discovery Studio, and toxicity profiles were assessed in silico using ECOSAR and Toxtree software.
Results: The analysis identified punicaflavone and 2-deoxybrassinolide as the compounds with the highest binding affinity, at -10.06 kcal/mol and -10.89 kcal/mol respectively, both surpassing acarbose’s -9.33 kcal/mol. These compounds interacted with 11 common residues in alpha-amylase, mirroring acarbose’s interactions. In silico toxicity analysis revealed that punicaflavone might pose risks to aquatic organisms but does not exhibit potential as a genotoxic or non-genotoxic carcinogen. Conversely, 2-deoxybrassinolide displayed moderate toxicity to aquatic organisms but was also free from genotoxic and non-genotoxic carcinogenic potential.
Conclusion: Punicaflavone and 2-deoxybrassinolide emerged as the most promising compounds, demonstrating strong binding affinities and similar interaction patterns with α-amylase as acarbose. Although both compounds may pose risks to aquatic environments, they do not show potential as genotoxic or non-genotoxic carcinogens, supporting their further exploration as anti-diabetic agents.
CERAI GUGAT KARENA KEKERASAN DALAM RUMAH TANGGA (Tinjauan Yuridis Putusan Pengadilan Agama Malang Nomor: 1172/Pdt.G/2017/PA.Mlg)
Authors: Aulia Sendy Ayu , Muflichah Siti , Faradz Haedah 
Published: May 2024

Salah satu alasan perceraian adalah perselisihan dan pertengkaran dimana biasanya perselisihan dan pertengkaran diakibatkan adanya Kekerasan Dalam Rumah Tangga. Kekerasan Dalam Rumah Tangga ada 4 macam yaitu kekerasan fisik, kekerasan psikis, kekerasan seksual dan penelantaran ekonomi, dalam hal ini terjadi Kekerasan Dalam Rumah Tangga khususnya kekerasan seksual, sehingga memicu salah satu pihak yaitu isteri memutuskan untuk mengajukan perceraian ke Pengadilan Agama. Permasalahan dalam penelitian ini yaitu pertimbangan hukum Hakim dalam memutus perkara cerai gugat karena Kekerasan Dalam Rumah Tangga yang terjadi di Pengadilan Agama Malang pada putusan nomor 1172/Pdt.G/2017/PA.Mlg. Metode penelitian yang digunakan dalam penulisan hukum ini adalah yuridis normatif. Hasil penelitian menunjukan bahwa pertimbangan hukum yang dipakai hakim Pengadilan Agama Malang pada putusan nomor 1172/Pdt.G/2017/PA.Mlg hanya mengacu pada ketentuan alasan perceraian Pasal 70 Undang-Undang Nomor 7 Tahun 1989 tentang Peradilan Agama Jo Pasal 19 huruf (f) dan Pasal 22 ayat (2) Peraturan Pemerintah Nomor 9 Tahun 1975 serta Pasal 116 huruf (d) dan huruf (f) KHI. Menurut Peneliti pertimbangan Hakim dalam memberikan pertimbangan dapat dilengkapi Pasal 39 ayat(2) huruf d Undang-Undang Nomor 1 Tahun 1974 Jo Pasal 19 Peraturan Pemerintah Nomor 9 Tahun 1975 Jo Pasal 116 (f) Kompilasi Hukum Islam dan Pasal 8 huruf b Undang-Undang Nomor 23 tahun 2004 tentang Penghapusan Kekerasan dalam Rumah Tangga.Kata Kunci: Perceraian; Kekerasan Dalam Rumah Tangga (KDRT)
PERLINDUNGAN HAK PRIVASI ATAS DATA PRIBADI ANAK MENURUT HUKUM INTERNASIONAL DAN HUKUM NASIONAL INDONESIA
Authors: Lazuardiansyah Azriel Fatahillah , Indriati Noer 
Published: May 2024

Penggunaan teknologi informasi di kalangan pelajar dan anak-anak bukanlah merupakan hal baru. Penggunaan platform layanan digital turut melahirkan berbagai tantangan yang berpotensi mengancam hak privasi atas data pribadi anak. Penelitian ini bertujuan untuk mengetahui pengaturan perlindungan hak privasi atas data pribadi anak menurut hukum internasional dan hukum nasional Indonesia, serta untuk menganalisis perlindungan hukum hak privasi atas data pribadi anak oleh Pemerintah Indonesia. Penelitian ini merupakan penelitian hukum normatif dengan metode pendekatan perundang-undangan dan pendekatan konseptual. Data yang digunakan adalah data sekunder dengan metode pengumpulan data berdasarkan studi kepustakaan kemudian disajikan dalam bentuk uraian sistematis dan logis serta menggunakan metode analisis kualitatif. Hasil penelitian dan pembahasan menunjukkan bahwa pengaturan secara umum menurut hukum internasional dapat ditemukan dalam: Pasal 12 Universal Declaration of Human Rights 1948 dan Pasal 17 International Covenant on Civil and Political Rights 1966. Pengaturan secara khusus: Pasal 16 Convention on the Rights of the Child 1989, OECD Council Recommendation on The Protection of Children Online 2012, APEC Privacy Framework 2015, Pasal 6, 8, & Pasal 38 General Data Protection Regulations 2018. Menurut hukum nasional Indonesia secara umum dapat ditemukan dalam: Pasal 28F & 28G UUD 1945; Pasal 14 UU No. 39 Tahun 1999 tentang Hak Asasi Manusia; Pasal 26 UU No. 19 Tahun 2016 tentang Informasi dan Transaksi Elektronik serta Pasal 3 dan Pasal 25 UU No. 27 Tahun 2022 tentang Perlindungan Data Pribadi. Pemerintah Indonesia turut berupaya memberikan perlindungan hukum mengesahkan UU No. 27 Tahun 2022 tentang Perlindungan Data Pribadi didukung dengan program Gerakan Nasional Literasi Digital. Perlindungan data pribadi anak dalam GNLD termasuk salah satu dari fokus kerja program GNLD untuk mendukung transformasi digital di Indonesia.
Elections: Between The Realization Of The People's Will And The Threat Of Oligarchy
Authors: Prasojo Hermawan 
Published: May 2024

General elections are one means to realize the people's will in a democratic country. However, realizing the people's will takes work, one of which is the threat of oligarchy in the political process through elections. This research examines the extent to which the people's will has been realized through existing laws and regulations and how the threat of oligarchy occurs in the political process. This research uses a normative, legislative, and conceptual method. Based on the results of the research, it is found that the election arrangements in the existing laws and regulations have generally supported the realization of the will of the people. However, gaps in the regulation of political party recruitment and political party funding can lead to oligarchic practices. Therefore, further study is needed to find a model for regulating political recruitment and funding of political parties.
Pembaharuan Hukum Pidana Tentang Penghapusan Kekerasan Seksual Terhadap Perempuan (Tinjauan Terhadap Undang-Undang No.12 Tahun 2022 Tentang Tindak Pidana Kekerasan Seksual)
Authors: Setiawati Yasinta 
Published: May 2024

Pemberantasan kekerasan seksual melalui sarana pidana telah mengalami pembaharuan melalui Undang-Undang Nomor 12 Tahun 2022 tentang Tindak Pidana Kekerasan Seksual. Artikel ini hendak mengungkap kriteria kekerasan seksual terhadap perempuan dan ruang lingkup perlindungan dalam Undang-Undang Tindak Pidana Kekerasan Seksual. Artikel ini merupakan penelitian normatif dengan berfokus pada data sekunder yang meliputi bahan hukum primer (regulasi) dan bahan hukum sekunder (referensi). Kriteria kekerasan seksual terhadap perempuan dalam Undang-Undang Tindak Pidana Kekerasan Seksual adalah pelecehan seksual, eksploitasi seksual, pemaksaan kontrasepsi, pemaksaan aborsi, pemerkosaan, pemaksaan perkawinan, pemaksaan pelacuran, perbudakan seksual, dan penyiksaan seksual. Ruang lingkup perlindungan dalam undang-undangan tersebut sesuai dengan Konvensi CEDAW sebagai acuannya dengan tujuan mereduksi potensi diskriminasi terhadap perempuan.
Peningkatan Kualitas Emping Melinjo melalui Proses Pengepresan dan Penurunan Kadar Purin di UKM Emping Jago
Authors: Nuary Rizky Brisha , Afiah Rahmania Nur , Asmediana Anis , Maghfira Lativa Lisya , Anandito R. Baskara Katri 
Published: May 2024

<em><em><strong>Quality Improvement of Emping Melinjo through Pressing Process and Reduction of Purin Level at SME Emping Jago.</strong> </em>Emping melinjo is one of the popular foods among Indonesians. Kartasura is one of the districts in Sukoharjo that has potential in the production of emping melinjo. This study aimed to improve the quality of emping melinjo by using a mechanical pressing machine and reducing the purin level. The method used was a literature review based on scientific journals, books, and others. The results were to substitute the pressing process using mechanical machinery and by soaking treatment to reduce the purin levels. The improvement on pressing process were performed as an innovation so the process will not depend on human workers. Then, the soaking in a 4% acetic acid solution (vinegar) varied for 0; 10; 20; and 40 minutes.The hypoxanthine and adenine levels (in micrograms per gram), according to the soaking duration, showed 46,43; 41,50; 41,05; 36,71; and 124,74; 110,90; 109,83; 108,82 respectively. <em>The 40 minutes soaking process could decrease the purin level by 20%.</em></em>
STUDY OF THERMAL COEFFICIENT OF LINEAR EXPANSION OF BIOCOMPATIBLE GLASS CRYSTALLINE MATERIALS BASED ON THE SYSTEM Li2O–СaO–ZrO2–TiO2–MgO–ZnO–Al2O3–B2O3–P2O5–SiO2
Authors: Babich Olena , Savvova Oksana , Fesenko Oleksii , Hopko Andrii 
Published: May 2024

The prospect of using biocompatible scaffolds with bone tissue architecture to replace large areas of bone tissue has been established. The necessity of creating reinforced porous bioactive glass-crystalline materials, which are operated under conditions of variable loads and characterized by high osteoconductive and osteoinductive properties, has been established. The main criteria for the formation of a reinforced hierarchical porous structure of bioactive glass-crystalline materials under the conditions of heat treatment have been determined. The choice of the system is justified Li2O–СaO–ZrO2–TiO2–MgO–ZnO–Al2O3–B2O3–P2O5–SiO2, within which the compositions of the OS series glasses with the content of the main components and modifying additives are selected, wt. %. %: CaF2 0,5–2,5; CeO2 0,01–0,05; SrO 0,01–0,05; Nb2O3 0,01–0,1; SrO 0,01–0,1 and with the ratio Са:P = 1,67 and SiO2:Li2O = 4,0 and glass-crystalline materials were developed, which are characterized by the content of crystalline phases of hydroxyapatite and lithium disilicate for the formation of a bioactive reinforced structure. The influence of the chemical and phase composition of model glasses on the crystallization ability and thermal properties of glass-crystalline materials based on them was analyzed. It was determined that the indicator TСLЕ indicator for experimental glass materials in the temperature range of 25–600 °С is 78–130,2·10-7°С-1 and is recognized by the type and content of crystalline phases and the composition of the glass phase. It was established that the formation of a sytalized interconnected structure with the presence of 50 vol. % hydroxyapatite and 10 об. % lithium with TСLЕ about 100·10-7°С-1, determines the possibility of obtaining high-quality durable and defect-free porous biocompatible materials and coatings on titanium alloys based on calcium-silicophosphate glass-crystalline materials for creating a single endoprosthesis design. The creation of reinforced nanostructured glass-crystalline materials with a hierarchical porous structure, the ability to withstand thermal loads and the formation of a strong connection with titanium alloys will allow solving the urgent problems of replacing significant areas of bone tissue.
INFLUENCE OF NATURAL FACTORS OF SUPPORTING RESERVOIR PRESSURE AT THE LATE STAGE OF DEVELOPMENT OF GAS CONDENSATE FIELDS
Authors: Fyk Illia , Rymchuk Danylo 
Published: May 2024

The object of the research is natural factors that can affect both the maintenance of reservoir pressure in the process of developing gas condensate fields and the recovery of depleted deposits. Such factors include: waterflooding of deposits, subsidence of the surface, elasticity of rocks, water and gas, initial gradients of reservoir pressure in deposits, capillary forces. When studying the recovery of reserves in depleted gas condensate fields, it is necessary to take into account the influence of the above factors on the maintenance of reservoir pressure in order to identify the volumes of gas that flow from deep horizons (external sources).
The paper shows the dynamics of waterflooding volumes and average reservoir pressures over the years. It is emphasized that waterflooding does not significantly affect the maintenance of reservoir pressure. Correlation dependencies of waterflooding volumes over time and the dependence of waterflooding volumes on reservoir pressure are given. An original system for calculating the volume of the water pressure system is proposed for the purpose of forecasting further waterflooding of deposits. The influences of all the above factors on the process of maintaining reservoir pressure are taken into account. It is shown that for the Shebelinsky GCF, all these factors do not significantly affect the recovery of reserves. The influence of capillary forces and evaporation of water in deposits on the development processes from the point of view of maintaining reservoir pressure at the late stage of GCF operation is studied.
WITHDRAWN: Green Credit, Green Reputation, and Risk-taking of Commercial Banks: Evidence from China
Authors: Liu Renzhong , Zheng Yanming , Huang Wenyao , Madsen Dag Øivind , Kuang Jinsong , Fan Xianyang 
Published: May 2024

Abstract

The full text of this preprint has been withdrawn by the authors as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
A cross-sectional study of the association of serum uric acid levels and sarcopenia in Chinese adults using the China Health and Retirement Longitudinal Study
Authors: Luo Kang , Xia Wenjing , Zhang Yingxiao , Yu Jing , Shu Yue , Yang Hong , Zhou Min , Chen Pan , Xiao Qian 
Published: May 2024

Abstract

Purpose
Previous research has yielded inconsistent findings concerning the relationship between serum uric acid levels and sarcopenia. However, there is currently no research that comprehensively examines this relationship within the broader Chinese population. This study aims to explore the relationship between serum uric acid levels and sarcopenia in Chinese adults aged 45 and above, focusing specifically on age-related variations.
Methods
The present study involved 10,938 participants of the 2015 China Health and Retirement Longitudinal Study (CHARLS). The associations between sarcopenia (including its components) and serum uric acid levels were evaluated using Weighted logistic and Weighted linear regression models. After categorizing participants by age groups, the subgroup analysis conducted allowed for a more detailed examination of age-related changes.
Results
Participants were stratified into quartiles based on their UA levels. Adjusted analyses revealed that a higher serum uric acid level was negatively associated with sarcopenia only in individuals aged 65 and older. Results from weighted linear regression analysis indicated a statistically significant positive correlation between serum uric acid levels and both handgrip strength (HGS) and skeletal muscle index (SMI). Moreover, the Q4 group (≥5.70 mg/dL) sustained this positive correlation across all ages.
Conclusion
The results indicated a noteworthy correlation between higher UA levels and elevated skeletal muscle index (SMI) and handgrip strength(HGS) among Chinese individuals aged 45 years and above. Elevated levels of blood uric acid may potentially exert a safeguarding influence against the onset of sarcopenia, particularly in individuals aged 65 years and above.
Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s disease
Authors: Howe Matthew D. , Britton Karysa J. , Joyce Hannah E. , Menard William , Emrani Sheina , Kunicki Zachary J. , Faust Melanie A. , Dawson Brittany C. , Riddle Meghan C. , Huey Edward D. , Janelidze Shorena , Hansson Oskar , Salloway Stephen P. 
Published: May 2024

Abstract

Background
With the approval of disease-modifying treatments (DMTs) for early Alzheimer’s disease (AD), there is an increased need for efficient and non-invasive detection methods for cerebral amyloid-β (Aβ) pathology. Current methods, including positron emission tomography (PET) and cerebrospinal fluid (CSF) analysis, are costly and invasive methods that may limit access to new treatments. Plasma tau phosphorylated at threonine-217 (P-tau217) presents a promising alternative, yet optimal cutoffs for treatment eligibility with DMTs like aducanumab require further investigation. This study evaluates the efficacy of one- and two-cutoff strategies for determining DMT eligibility at the Butler Hospital Memory & Aging Program (MAP).
Methods
In this retrospective, cross-sectional diagnostic cohort study, we first developed P-tau217 cutoffs using site-specific training data and BioFINDER-2, which were then tested in potential DMT candidates from Butler MAP (total n = 150). ROC analysis was used to calculate the area under the curve (AUC) and accuracy of P-tau217 interpretation strategies, using Aβ-PET/CSF testing as the standard of truth.
Results
Potential DMT candidates at Butler MAP (n = 50), primarily diagnosed with mild cognitive impairment (n = 29 [58%]) or mild dementia (21 [42%]), were predominantly Aβ-positive (38 [76%]), and half (25 [50%]) were subsequently treated with aducanumab. Elevated P-tau217 predicted cerebral Aβ positivity in potential DMT candidates (AUC = 0.97 [0.92-1]), with diagnostic accuracy ranging from 0.88 (0.76–0.95, p = 0.028) to 0.96 (0.86-1, p < .001). When using site-specific cutoffs, a subset of DMT candidates (10%) exhibited borderline P-tau217 (between 0.273 and 0.399 pg/mL) that would have potentially required from confirmatory testing.
Conclusions
This study, which included participants treated with aducanumab, confirms the utility of one- and two-cutoff strategies for interpreting plasma P-tau217 in assessing DMT eligibility. Using P-tau217 could potentially replace more invasive diagnostic methods, and all aducanumab-treated participants would have been deemed eligible based on P-tau217. However, false positives remain a concern, particularly when applying externally derived cutoffs that exhibited lower specificity which could have led to inappropriate treatment of Aβ-negative participants. Future research should focus on prospective validation of P-tau217 cutoffs to enhance their generalizability and inform standardized treatment decision-making across diverse populations.
Metal(loid) tolerance, accumulation, and phytoremediation potential of wetland macrophytes for multi-metal(loid)s polluted water.
Authors: Khan Aqib Hassan Ali , Velasco-Arroyo Blanca , Rad Carlos , Curiel-Alegre Sandra , Rumbo Carlos , De Wilde Herwig , Pérez-de-Mora Alfredo , Martel-Martín Sonia , Barros Rocío 
Published: May 2024

Abstract

Natural based solutions, notably constructed/artificial wetland treatment systems, rely heavily on identification and use of macrophytes with the ability to tolerate multiple contaminants and grow for an extended period to reduce contamination. The potential to tolerate and remediate metal(loid) contaminated groundwater from an industrial site located in Flanders (Belgium) was assessed for 10 wetland macrophytes (including Carex riparia, Cyperus longus, Cyperus rotundus, Iris pseudacorus, Juncus effusus, Lythrum salicaria, Menta aquatica, Phragmites australis, Scirpus holoschoenus, and Typha angustifolia). The experiment was conducted under static conditions, where plants were exposed to polluted acidic (pH~4)water, having high level of metal(loid)s for 15 days. Plant biomass, morphology, and metal uptake by roots and shoots were analysed every 5 days for all species. T. angustifolia and S. holoschoenus produced ~3 and ~1.1 times more dried biomass than the controls, respectively. For S. holoschoenus, P. australis, and T. angustifolia, no apparent morphological stress symptoms were observed, and plant heights were similar between control and plants exposed to polluted groundwater. Higher concentrations of all metal(loid)s were detected in the roots indicating a potential for phytostabilization of metal(loid)s below the water column. For J. effusus and T. angustifolia, Cd, Ni, and Zn accumulation was observed higher in the shoots. S. holoschoenus, P. australis, and T. angustifolia are proposed for restoration and phytostabilization strategies in natural and/or constructed wetland and aquatic ecosystems affected by metal(loid) inputs.
Lecturers’ perceptions of evidence-based practice training among undergraduate healthcare students in developing countries at Makerere University College of Health Sciences in Uganda
Authors: Nalweyiso Dorothy Irene , Kabanda Joseph , Mbabazi Johnson , Breckon Jeff , Nnyanzi Lawrence Achilles , Kawooya Michael Grace , Mubuuke Aloysius Gonzaga , Saltikov Josette Bettany , Sanderson Katherine 
Published: May 2024

Abstract

Background
Evidence-based practice (EBP) has been promoted for the last 40 years to enhance health outcomes, which has led developing countries like the United Kingdom (UK) to engage in EBP. However, EBP is relatively new in developing countries, so it is critical to maximise the scarce healthcare resources. EBP training improves the use of evidence in healthcare practice, but the differences between countries necessitate specific interventions.
Methods
In this study, semi-structured in-depth interviews were used, and twelve participants were a sufficient sample size to achieve rich data saturation [24].
Results
Using thematic analysis, seven themes were generated from the study, although four themes are presented here. These include EBP is a new concept at Mak-CHS. The importance of EBP in healthcare delivery involves working with stakeholders in EBP education and teaching EBP. The results also showed that there are several institutional and individual constraints that prevent lecturers and students from using EBP. These include, but are not limited to, a lack of EBP skills and resources. To increase EBP knowledge, skills, attitude, and behaviour among lecturers and healthcare students, it is essential to incorporate EBP into the curricula of undergraduate healthcare students, train lecturers, and work with all stakeholders at all levels of management so that the required resources are available for EBP implementation.
Conclusion
This study suggests that putting EBP into practice necessitates institutional and interdisciplinary collaboration as well as personal commitment.