bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Ion–Proton Differential Speed between Interplanetary Coronal Mass Ejections and Solar Wind near 1 au
Authors: Zhang Xuechao , Song Hongqiang , Zhang Chengxiao , Fu Hui , Li Leping , Li Jinrong , Wang Xiaoqian , Wang Rui , Chen Yao 
Published: May 2024

Abstract
The elemental abundance of interplanetary coronal mass ejections (ICMEs) and solar wind near 1 au is often adopted to represent the abundance in the corresponding coronal sources. However, the absolute abundance of heavy ions (relative to hydrogen) near 1 au might be different from the coronal abundance due to the ion–proton differential speed (V

ip
). To illustrate the V

ip
characteristics and explore whether it influences the absolute abundance analysis for ICMEs and solar wind, we perform a statistical study on the V

ip
for He2+, C5+, O6+, and Fe10+ in both ICMEs and solar wind based on measurements of Advanced Composition Explorer. The results show that the V

ip
is negligible within ICMEs and slow solar wind (< 400 km s−1), while obvious in the intermediate (400–600 km s−1) and fast wind (> 600 km s−1). Previous studies showed that the V

ip
in ICMEs keeps negligible during propagation from 0.3 to 5 au, but in solar wind it increases with the decreasing heliocentric distance. Therefore, it might be questionable to infer the absolute abundance of coronal sources through in situ abundance near 1 au for solar wind. Fortunately, the ion–oxygen (O6+) differential speed (V

io
) is negligible for He2+, C5+, and Fe10+ within both ICMEs and solar wind, and previous studies suggested that the V

io
does not vary significantly with the heliocentric distance. This indicates that various heavy ions always flow at the same bulk speed and their relative abundance (relative to oxygen) near 1 au can represent the coronal abundance for both ICMEs and solar wind.
CANE, a Component of the NLRP3 Inflammasome, Promotes Inflammasome Activation
Authors: Kaneko Naoe , Kurata Mie , Yamamoto Toshihiro , Sakamoto Akimasa , Takada Yasutsugu , Kosako Hidetaka , Takeda Hiroyuki , Sawasaki Tatsuya , Masumoto Junya 
Published: May 2024

Abstract
The nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3, also called cryopyrin) inflammasome is an intracellular innate immune complex, which consists of the pattern-recognition receptor NLRP3, the adaptor apoptosis-assciated speck-like protein containing a caspase recruitment domain, and procaspase-1. Aberrant activation of the NLRP3 inflammasome causes an autoinflammatory disease called cryopyrin-associated periodic syndrome (CAPS). CAPS is caused by gain-of-function mutations in the NLRP3-encoding gene CIAS1; however, the mechanism of CAPS pathogenesis has not been fully understood. Thus, unknown regulators of the NLRP3 inflammasome, which are associated with CAPS development, are being investigated. To identify novel components of the NLRP3 inflammasome, we performed a high-throughput screen using a human protein array, with NLRP3 as the bait. We identified a NLRP3-binding protein, which we called the cryopyrin-associated nano enhancer (CANE). We demonstrated that CANE increased IL-1β secretion after NLRP3 inflammasome reconstitution in human embryonic kidney 293T cells and formed a “speck” in the cytosol, a hallmark of NLRP3 inflammasome activity. Reduced expression of endogenous CANE decreased IL-1β secretion upon stimulation with the NLRP3 agonist nigericin. To investigate the role of CANE in vivo, we developed CANE-transgenic mice. The PBMCs and bone marrow–derived macrophages of CANE-transgenic mice exhibited increased IL-1β secretion. Moreover, increased autoinflammatory neutrophil infiltration was observed in the s.c. tissue of CANE-transgenic versus wild-type mice; these phenotypes were consistent with those of CAPS model mice. These findings suggest that CANE, a component of the NLRP3 inflammasome, is a potential modulator of the inflammasome and a contributor to CAPS pathogenesis.
Value of cognitive fusion targeted and standard systematic transrectal prostate biopsy for prostate cancer diagnosis
Authors: Yu Lu-Ping , Du Yi-Qing , Sun Yi-Ran , Qin Cai-Peng , Yang Wen-Bo , Huang Zi-Xiong , Xu Tao 
Published: May 2024

Abstract
The aim of this study was to compare the accuracies of cognitive fusion-guided targeted biopsy (TB), systematic biopsy (SB), and combined TB+SB for the detection of prostate cancer (PCa) and clinically significant PCa (csPCa) in males with lesions detected by magnetic resonance imaging (MRI). We conducted a retrospective analysis of individuals who underwent prostate biopsy at Peking University People’s Hospital (Beijing, China), with an emphasis on patients with both transrectal TB and SB. The main objective was to determine the precisions of SB, TB, and TB+SB for diagnosing PCa and csPCa. We also evaluated the detection rates of TB, SB, TB+ipsilateral-SB (ipsi-SB), TB+contralateral-SB (contra-SB), and TB+SB for PCa and csPCa in patients with unilateral MRI lesions. We compared the diagnostic yields of the various biopsy schemes using the McNemar’s test. A total of 180 patients were enrolled. The rates of PCa detection using TB, SB, and TB+SB were 52.8%, 62.2%, and 66.7%, respectively, and the corresponding rates for csPCa were 46.1%, 56.7%, and 58.3%, respectively. Among patients with unilateral MRI lesions, the PCa detection rates for TB, SB, TB+ipsi-SB, TB+contra-SB, and TB+SB were 53.3%, 64.8%, 65.6%, 61.5%, and 68.0%, respectively. TB+ipsi-SB detected 96.4% of PCa and 95.9% of csPCa cases. These findings suggest that the combination of TB+SB has better diagnostic accuracy compared with SB or TB alone. For patients with unilateral MRI lesions, the combination of TB+ipsi-SB may be suitable in clinical settings.
Predictive parameters of the efficacy of varicocele repair: a review
Authors: Crafa Andrea , Cannarella Rossella , Condorelli Rosita A , Mongioì Laura M , Vignera Sandro La , Calogero Aldo E 
Published: May 2024

Abstract
Varicocele has a prevalence of 15% in the population and represents a primary cause of infertility in 40% of cases and a secondary cause in approximately 80% of cases. It is considered the major correctable cause of male infertility. Despite its high prevalence in the infertile population, a large number of patients with varicocele do not experience reproductive difficulties. For this reason, it is still highly debated which parameters could be used to predict which patients with varicocele will be most likely to benefit from its repair. The main international and European guidelines state that treatment should only be considered in infertile patients with abnormal sperm quality. However, these guidelines do not help physicians to identify which of these patients may benefit from the treatment. Therefore, this narrative review collects the evidence in the literature on the usefulness of some factors as predictors of improvement, highlighting how some of them may be effective in an initial selection of patients to be treated, while others are promising but further studies are needed. Finally, a brief consideration on the possible role of artificial intelligence is proposed.
Developing Porcine Acellular Dermal Matrix by Using Sodium Dodecyl Sulfate and Biomechanical Property Testing
Authors: Primasari Medisa , Saputro Iswinarno Doso , Hariani Lynda , Velusamy Glorian Paul Bosco 
Published: May 2024

ABSTRACT

Introduction:
An alternative for supporting wound closure is acellular dermal matrix (ADM), which serves as a scaffold. Humans and porcine possess a similar biochemical makeup. Using sodium dodecyl sulfate (SDS), a decellularization technique was developed and its biomechanical properties were assessed.

Methods:
This work uses a pig dermis layer for an in vitro experimental investigation with a posttest-only control group. Using SDS 0.5% for 14 days, the decellularization procedure compares the biomechanical properties and cellular components of the ADM with control. The Mann–Whitney U-test for data with a nonnormal distribution or the t-test for continuous variables with a normal distribution was used for the study.

Results:
Histological analysis revealed that none of the cells were detected in four fields of analysis in the treatment group; however, 48.00 ± 4.86 cells were observed in the control group (P < 0.001); the collagen organization in the control group appeared to be identical. The variables elastic modulus (MPa) (136.78 vs. 129.19; P = 0.556), thickness (mm) (3.27 vs. 3.15; P = 0.397), and width (mm) (8.50 vs. 8.56; P = 0.40) did not differ statistically. The following data showed significant differences between the treatment group and the control group: break strain (%) (108.46 vs. 67.48; P < 0.001) and tensile strength stress (MPa) (19.916 vs. 22.1; P = 0.030).

Conclusions:
SDS decellularization is an efficient method for creating an ADM. Although the break strain was considerably lower, the treatment group’s tensile strength was higher. Elastic modulus changes were not observed.
Intrachromosomal amplification of chromosome 21 in Egyptian pediatric B-lineage acute lymphoblastic leukemia: a hospital-based observational study
Authors: Elhameed Amal Abd , El-Gamal Rasha , Hasan Esraa , Mohamed Nagy Reham 
Published: May 2024

Abstract

Objective
This study was conducted to evaluate the clinicopathologic features as well as the association between the intrachromosomal amplification of chromosome 21 (iAMP21) and the clinical outcome in Egyptian patients with B-cell acute lymphoblastic leukemia (B-ALL) attending/admitted in the Department of Pediatric Oncology of our university hospital.

Patients and methods
This was a prospective study conducted on 25 newly diagnosed and five relapsed pediatric patients with B-ALL (23 males and seven females), with a mean age of 7.76 ± 5.11 years. Bone marrow aspiration was done to diagnose and evaluate remission of participants, and fluorescence in situ hybridization (FISH) analysis using the ETV6-RUNX1 probes was used to detect RUNX1 amplification.

Results
iAMP21 was identified in 28% of newly diagnosed patients with B-ALL and in 80% of relapsed cases with B-ALL. There was a significant association between positive iAMP21 cases and failure to attain complete remission at day 28 (P=0.004). A significant relationship among the 14 patients monitored for disease outcome was found between the presence of iAMP21 and occurrence of relapse or death in newly diagnosed, or failure to achieve complete remission or death in relapsed cases (P=0.036).

Conclusion
There was a higher incidence of iAMP21 among our Egyptian pediatric B-ALL cases and unfavorable effect of iAMP21 on patients’ prognosis even with coexistence of ETV6-RUNX1.
Does platelet aggregation differ among chronic myeloid leukemia-chronic phase (CML-CP) patients on tyrosine kinase inhibitors (TKIs)? A tertiary center experience
Authors: Moeen Sawsan M , Afifi Ola A , Thabet Ahmad F , Saleh Medhat A , Morad Mohamed A 
Published: May 2024

Abstract

Background
Tyrosine kinase inhibitors (TKIs) have improved the prognosis of chronic myeloid leukemia (CML) by inhibiting the BCR-ABL kinase. There are concerns regarding the effect of TKI on hemostasis by inhibiting platelet aggregation; the possible reason for this is yet unclear.

Objectives
To study platelet aggregation response to different agonists [(adenosine diphosphate (ADP), collagen, and arachidonic acid (AA)] using platelet aggregometry in 75 CML-chronic phase (CML-CP) patients on TKI therapy, in complete hematologic response (CHR).

Patients and methods
This study included 75 CML patients of both sexes of age 32–66 years. A detailed medical history, clinical examination, and platelet aggregation by PAP-4 platelet aggregometer were done for all patients.

Results
Imatinib-treated CML patients had a lower platelet aggregation response to AA (less than 50% aggregation) than those on nilotinib either first- or second-line treatment, in a statistically significant manner (P=0.001, P=0.025) for both comparisons. But there was no statistically significant difference in platelet aggregation between patients on nilotinib either first- or second-line therapy (P=0.073).

Conclusion
Platelet aggregation response to collagen and ADP was normal in all CML-CP patients, but it had an impaired response to AA<AQ: Pls check whether the change is appropriate>. Further studies are needed to establish the particular mechanism of this inhibition.
Patent Ductus Arteriosus Device Closure in Interrupted Inferior Vena Cava
Authors: Rajan Palanivel , Barwad Parag , Aggarwal Pankaj , Rohit Manoj Kumar 
Published: May 2024

Interrupted inferior vena cava (IVC) with azygous continuation provides technical challenge in many percutaneous cardiac interventions. They are performed via the femoral venous access route. We describe four such cases in whom, patent ductus arteriosus (PDA) device closure was done in interrupted IVC. All the four cases were done using the femoral route. Two cases were done via retrograde approach through femoral artery access, in which one was closed with a muscular VSD device and the other with a Gianturco coil.
The introduction of newer closure devices helps in the retrograde approach. Two cases were done via anterograde approach through the femoral venous route, with a loop through the azygous vein. One child had transient bradycardia due to cardiac stretch which normalized after the device deployment and introducer system removal.
Thus, we describe different femoral approaches in interrupted IVC patients for PDA closure, with the difficulties faced and the complications managed.
Out-of-Hospital Cardiac Arrest in the Young
Authors: Albizreh Bassim , Arabi Abdulrahman , Al Suwaidi Jassim , Patel Ashfaq , Singh Rajvir , Albinali Hajar 
Published: May 2024

Background:
Worldwide, limited data are available about young patients (≤40 years) who present with out-of-hospital cardiac arrest (OHCA). We compared demographic characteristics, clinical presentation, and outcome in younger patients (≤40 years) versus older patients (>40 years) with OHCA.

Materials and Methods:
This was a retrospective analysis of a registry of patients hospitalized with OHCA over a 23-year period (1991–2013) in Hamad Medical Corporation, Doha, Qatar.

Results:
Of 1146 patients admitted to our institution with OHCA, 159 patients (13.9%) were 40 years of age or younger. Compared to the older group (>40 years), younger group patients were more likely to be males (84.9% vs. 71.5%; P = 0.001) and to be smokers (27.7% vs. 19.7%; P = 0.012). They are less likely to have diabetes (6.3% vs. 49.2%; P = 0.001), hypertension (8.3% vs. 49.9%; P = 0.001), prior myocardial infarction (3.1% vs. 23.4%; P = 0.001), or chronic renal disease (0% vs. 8.5%; P = 0.001). There was no significant difference in ejection fraction, ST-elevation myocardial infarction (13.2% vs. 15.7%; P = 0.41), utilization of inotropes (36.5% vs. 44%; P = 0.08), or utilization of reperfusion therapy (thrombolytic: 16.4% vs. 12.2%, P = 0.14, and percutaneous intervention: 6.3% vs. 5.3%, P = 0.60, for the younger and older groups, respectively); on the other hand, younger patients were more likely to receive antiarrhythmic medications (33.3% vs. 21.2%; P = 0.001). Inhospital mortality was lower in the younger group (52.1% vs. 68.3%; P = 0.001) even after adjustment for baseline variables.

Conclusion:
In the Middle East it is not uncommon to present with OHCA in young age. These patients are predominantly males, more likely to present with arrhythmia and they have a better survival rate.
COVID-19 Pandemic and Volume of Cardiac Catheterization Procedures in Jordan
Authors: Alhaddad Imad A. , Tabbalat Ramzi , Hammoudeh Ayman 
Published: May 2024

Introduction:
Global surge of COVID-19 forced most countries to impose variable measures to curb the disease. Jordan imposed one of the strictest lockdowns from mid-March through April 2020. Hospitals deferred elective cardiac catheterization procedures and most of those performed during that period were limited to urgent presentations. Our purpose is to evaluate the impact of strict lockdown on cardiac catheterization procedural volume.

Methods and Results:
We collected data about the numbers of all coronary angiography (CA) and percutaneous coronary intervention (PCI) procedures performed in 5 tertiary care hospitals in Amman, Jordan, from January through June 2020. We compared the volume of procedures performed in April 2020 (the strict lockdown month) to the corresponding period of prior year (April 2019) and to volumes performed prior to the lockdown in January–February 2020.
There was a 64% decline in CA and PCI volumes in April 2020 compared to April 2019. Comparing number of procedures performed in April 2020 to those in January–February 2020, there was 59% decline in CA and a 60% decline in PCI volumes. Following partial lifting of lockdown in May–June 2020, procedural volumes increased gradually.

Conclusion:
Strict COVID-19-related lockdown in Jordan was associated with drastic declines in cardiac catheterization procedural volumes.
Complications of White-coat Hypertension Compared to a Normotensive and Hypertensive Population
Authors: Taher Ziad Abdullah , Khayyat Waleed W. , Balubaid Marwan M. , Tashkandi Mohamed Y. , Alamoudi Saeed M. , Kinsara Abdulhalim Jamal 
Published: May 2024

Background:
Accumulating evidence demonstrates that white-coat hypertension (WCH) are associated with several risks and complications. In this study, we aimed to investigate the adverse effects of WCH compared with hypertensive and normotensive patients.

Methods:
A retrospective cohort study was conducted over five years. Blood pressure (BP) data was collected from both clinic visits and 24-h ambulatory blood pressure monitoring (ABPM) reports. Epidemiological data and complications, cardiac and noncardiac, were also recorded.

Results:
In total, 286 participants who were followed up for at least three years were included. The sample was divided into 99 normotensive patients (as a control group), 94 patients with clinically diagnosed hypertension (HTN), and 93 patients with WCH. Ischemic heart disease (IHD) was the most noted complication in the WCH group with a relative risk of 9.58 (1.23–74.16) (P = 0.008). Acute coronary syndrome (ACS) was significantly correlated with a relative risk of 2.06 (0.52–13.38). No significant correlation was noted with noncardiac complications. Both HTN and WCH groups showed a significant association with blood pressure variability (BPV). WCH was associated with an increased BPV in ambulatory daytime systolic measurements (P = 0.031) and a unique increase in diastolic measurement variability in office BP measurements (P = 0.020).

Conclusion:
WCH should be managed as HTN. WCH is associated with cardiac complications, particularly IHD, specifically in patients 55 years and older. WCH was significantly associated with a higher BPV in both ABPM and office-based measurements.
Probiotics in Dermatology: An Evidence-based Approach
Authors: Gowda Vaishnavi , Sarkar Rashmi , Verma Damini , Das Anupam 
Published: May 2024

Abstract
Probiotics are viable microorganisms that confer health benefits when administered to the host in adequate amounts. Over the past decade, there has been a growing demand for the use of oral and topical probiotics in several inflammatory conditions such as atopic dermatitis, psoriasis, acne vulgaris, etc., although their role in a few areas still remains controversial. The objective of this article is to shed light on understanding the origin and implications of microbiota in the pathophysiology of these dermatological conditions and the effect of probiotic usage. We have conducted a comprehensive search of the literature across multiple databases (PubMed, EMBASE, MEDLINE, and Google Scholar) on the role of probiotics in dermatological disorders. Commensal microbes of the skin and gastrointestinal tract play an important role in both health and disease. Increased use of probiotics has asserted a good safety profile, especially in this era of antibiotic resistance. With the advent of new products in the market, the indications, mechanism of action, efficacy, and safety profile of these agents need to be validated. Further studies are required. Oral and topical probiotics may be tried as a treatment or prevention modality in cutaneous inflammatory disorders, thus facilitating decreased requirement for topical or systemic steroids and antimicrobial agents. Tempering microbiota with probiotics is a safe and well-tolerated approach in this era of antimicrobial resistance.
Vascular Endothelial Growth Factor Expression by Immunohistochemistry as a Possible Indicator of Prognosis in Invasive Breast Carcinoma of No Special Type
Authors: Sindhura Nugala , Kaumudi Konkay 
Published: May 2024

Context:
Angiogenesis, the formation of new blood vessels from preexisting vascular network, is essential for tumor growth and spread. Vascular endothelial growth factor (VEGF) is a potent angiogenic growth factor.

Aims:
To assess the expression of VEGF in invasive carcinoma of no special type and its correlation with all the known prognostic factors of breast carcinoma.

Settings and Design:
Descriptive.

Materials and Methods:
Mastectomy specimens were studied noting the clinical details. The formalin-fixed tissues were subjected to routine processing and hematoxylin and eosin sections and studied extensively for all the histological prognostic factors. Representative sections from each case with the tumor were subjected to immunohistochemistry (IHC) staining with VEGF, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/neu) antibodies.

Statistical Analysis Used:
Descriptive statistics, Chi-square tests, contingency table analysis using SPSS for Windows.

Results:
One hundred and twelve cases of invasive carcinoma of special type were studied to evaluate various clinicopathological parameters. The association of VEGF with clinicopathological parameters and all the known prognostic factors was studied to note its significance. VEGF overexpression was observed in 69% of the cases. It was noted that larger tumor size, higher histological grade, lymphovascular invasion, nodal involvement, tumor necrosis, high microvessel density, ER negativity, PR negativity, and HER2/neu positivity had a significant statistical association with VEGF overexpression.

Conclusions:
We conclude that incorporating VEGF as a biomarker along with the known factors into a prognostic index will not only help predict clinical outcome more accurately, but also determines the patient who can be benefited with combinational therapy including anti-VEGF factors.