bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐grade bladder cancer: Association of the apparent diffusion coefficient with metastatic disease: Preliminary results
Authors: Rosenkrantz Andrew B. , Mussi Thais C. , Spieler Bradley , Melamed Jonathan , Taneja Samir S. , Huang William C. 
Published: January 2012

AbstractPurpose:To assess the utility of apparent diffusion coefficient (ADC) values obtained from diffusion‐weighted imaging (DWI) in distinguishing high‐grade bladder cancer with and without metastatic disease.Materials and Methods:Seventeen patients with histologically confirmed high‐grade bladder cancer who underwent pelvic magnetic resonance imaging (MRI) at 1.5T including DWI using b‐values of 0, 400, and 800 sec/mm2 were assessed. Histologic findings and follow‐up imaging were used to establish the reference standard in terms of metastatic disease. Two radiologists independently recorded ADC of all lesions following a training session, with their results averaged. Mann–Whitney U‐test, receiver operating characteristic (ROC) curve analysis and intraclass correlation coefficient (ICC) were used for data analysis.Results:Metastatic disease was characterized as present or absent in eight and nine patients, respectively. ADC was significantly lower among cases with metastatic disease than among cases without metastatic disease, both within the entire cohort (1.07 ± 0.18 × 10−3 mm2/s vs. 1.45 ± 0.22 × 10−3 mm2/s; P = 0.002) and within the subset of patients with muscle‐invasive tumor (1.06 ± 0.19 × 10−3 mm2/s vs. 1.45 ± 0.23 × 10−3 mm2/s; P = 0.017). Area under the ROC curve for identifying metastatic disease using ADC was 0.944, with optimal threshold of 1.21 × 10−3 mm2/s, which was associated with a sensitivity of 87.5%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 90.0%. Interreader agreement for ADC was excellent (ICC = 0.91).Conclusion:In this preliminary study, ADC was significantly different between cases of high‐grade urothelial carcinoma of the bladder with and without metastatic disease. These results may have value in assessing the metastatic potential of patients with localized high‐grade tumors of the bladder. J. Magn. Reson. Imaging 2012;35:1478–1483. © 2012 Wiley Periodicals, Inc.
Contrast‐enhanced MRI index of diffuse myocardial fibrosis is increased in primary aldosteronism
Authors: Su Mao‐Yuan M. , Wu Vin‐Cent , Yu Hsi‐Yu , Lin Yen‐Hung , Kuo Chin‐Chi , Liu Kao‐Lang , Wang Shuo‐Meng , Chueh Shih‐Chieh , Lin Lian‐Yu , Wu Kwan‐Dun , Tseng Wen‐Yih I. 
Published: January 2012

AbstractPurpose:To assess the degree of myocardial fibrosis in patients with primary aldosteronism (PA).Materials and Methods:Twenty‐five patients with PA and 12 age‐matched healthy volunteers underwent cine and late gadolinium enhancement (LGE) magnetic resonance imaging (MRI) on a 1.5 T MR system. From volume–time curves of cine MRI, the time for deceleration (Tdec) was determined to assess the left ventricle (LV) chamber stiffness. Based on phase‐sensitive reconstructed LGE images, a fibrosis index called enhancement value (EV) was computed as the signal intensity change in the myocardium over blood before and after contrast. Both Tdec and EV were compared between patients and controls. The association between Tdec and EV was investigated.Results:Patients showed a significantly higher EV (0.43 ± 0.05 vs. 0.36 ± 0.07; P = 0.002) and a significantly shorter Tdec (11.5 ± 3.5 %RR vs. 15.3 ± 2.4 %RR; P = 0.004) than controls. Significant correlations between EV and Tdec were observed in patients (r = −0.46, P = 0.018), in controls (r = −0.68, P = 0.015) and in all subjects (r = −0.63, P < 0.001).Conclusion:The fibrosis index is increased in patients with PA and the increase imposes an adverse effect on LV diastolic function. J. Magn. Reson. Imaging 2012;35:1349–1355. © 2012 Wiley Periodicals, Inc.
3D‐liver perfusion MRI with the MS‐325 blood pool agent: A noninvasive protocol to asses liver fibrosis
Authors: Leporq Benjamin , Dumortier Jérôme , Pilleul Frank , Beuf Olivier 
Published: January 2012

AbstractPurpose:To evaluate a 1.5T magnetic resonance imaging (MRI) protocol, including a dedicated acquisition sequence and a postprocessing tool for the quantitative analysis of hepatic tissue perfusion. Estimated perfusion parameters and histological results based on the METAVIR classification were prospectively compared for hepatic fibrosis assessment.Materials and Methods:The study protocol was approved by the experimentation Ethics Committee and informed consent was obtained. Sixteen patients (6 women, 10 men; average age, 52.4 ± 14.8 years) with chronic liver diseases were prospectively enrolled after a liver biopsy. MS‐325 (paramagnetic blood pool agent)‐enhanced MRI was performed using a free‐breath 3D‐VIBE T1w sequence. Image volumes were registered by an automatic rigid method. Liver perfusion was modeled by a dual‐input‐one‐compartment model and quantitative perfusion parameters such as arterial, portal, and total perfusion mean transit time (MTT) and hepatic perfusion index (HPI) were obtained using in‐house developed software.Results:Arterial perfusion increased with METAVIR stage, whereas portal perfusion decreased leading to an HPI increase with fibrosis stage. MTT increased with F3, F4. A nonparametric Mann–Whitney test demonstrated that HPI and portal perfusion were relevant in discriminating between advanced and nonadvanced fibrosis, between fibrosis and cirrhosis, then between nonfibrosis and fibrosis (P < 0.01). A strong correlation was found between portal perfusion fall‐off and HPI increase (r = −0.97; P < 0.001). HPI and portal perfusion were strongly correlated with fibrosis stage (r = 0.83 and −0.88; P < 0.001, respectively).Conclusion:HPI and portal perfusion could be relevant indicators for the clinical follow‐up in patients with chronic liver diseases. J. Magn. Reson. Imaging 2012;35:1380–1387. © 2012 Wiley Periodicals, Inc.
Bridge building within the province of proactivity
Authors: Fuller Jerry Bryan , Marler Laura E. , Hester Kim 
Published: January 2012

SummaryThe research questions posed in this study highlight the importance of valuing proactivity in both prompting an individual to engage in proactive behavior and encouraging the expression of that behavior. We integrate a variety of constructs from the proactivity literature to gain a deeper understanding of proactive behavior as it relates to proactive motivation and supervisory performance evaluations. First, we draw upon self‐determination theory, expectancy–value theory, and the recent integration of the proactive motivation literature to hypothesize that proactive behavior is predicted by the interaction of “can do” and “reason to” proactive motivational states. Second, on the basis of performance theory, we hypothesize that the relationship between proactive behavior and performance depends upon the extent to which the supervisor values proactivity. Specifically, we argue that supervisors with proactive personalities are more likely to value and reward subordinate proactive behavior than passive supervisors. Results provide support for both of our hypotheses. Interestingly, results show that proactive behavior did not result in negative consequences but rather that there was a cost (i.e., lower performance rating) for not taking charge for employees with proactive supervisors. Copyright © 2012 John Wiley & Sons, Ltd.
Burnout, employee engagement, and coping in high‐risk occupations
Authors: Falkoski Jennifer 
Published: January 2012

AbstractThis study assessed whether there were any significant relationships among burnout, type of coping, and employee engagement in a population of employees actively working in the medical and mental health fields. It also evaluated preferred workplace motivators across two overarching job categories: medical and mental health caregivers and administrative and supporting roles. The results showed that as employee burnout increased, so did the use of more harmful coping mechanisms. The study also found an inverse relationship between emotional exhaustion and employee engagement. Additionally, employee engagement and personal accomplishment were positively related. Employee‐preferred workplace motivators across two job‐overarching job categories were also assessed. The highest‐ranking employee‐preferred workplace motivators identified in the participant sample were nature of the work itself, responsibility, salary, relationship with peers, and professional growth.
A model for femininity and military leadership
Authors: Walker Karen M. 
Published: January 2012

AbstractAlthough the concept of women as leaders is not a novelty, recent trends have women breaking through traditional “glass ceilings,” thus pioneering female leadership roles in the workplace and the military. Women in leadership is a movement, a paradigm shift. The author offers a unique leadership model calculated from an instrumental multiple case study analysis of female military officers leading in male‐dominated environments. The model proposes four principle dimensions: femininity, self‐efficacy, emotional intelligence, and teamwork (F‐SET). It has a feminist appeal, although it engages leadership theory from other innovative angles.
Evaluation of different methods of protein extraction and identification of differentially expressed proteins upon ethylene‐induced early‐ripening in banana peels
Authors: Zhang Li‐Li , Feng Ren‐Jun , Zhang Yin‐Dong 
Published: January 2012

AbstractBACKGROUND: Banana peels (Musa spp.) are a good example of a plant tissue where protein extraction is challenging due to the abundance of interfering metabolites. Sample preparation is a critical step in proteomic research and is critical for good results.RESULTS: We sought to evaluate three methods of protein extraction: trichloroacetic acid (TCA)‐acetone precipitation, phenol extraction, and TCA precipitation. We found that a modified phenol extraction protocol was the most optimal method. SDS‐PAGE and two‐dimensional gel electrophoresis (2‐DE) demonstrated good protein separation and distinct spots of high quality protein. Approximately 300 and 550 protein spots were detected on 2‐DE gels at pH values of 3–10 and 4–7, respectively. Several spots were excised from the 2‐DE gels and identified by mass spectrometry.CONCLUSIONS: The protein spots identified were found to be involved in glycolysis, the tricarboxylic acid cycle, and the biosynthesis of ethylene. Several of the identified proteins may play important roles in banana ripening. Copyright © 2012 Society of Chemical Industry
Simultaneous determination of non‐steroidal anti‐inflammatory drugs in river water by gas chromatography‐mass spectrometry
Authors: Shin Ho‐Sang , Oh Jin‐Aa 
Published: January 2012

AbstractThe gas chromatography/mass spectrometric assay method was developed for the determination of 13 non‐steroidal anti‐inflammatory drugs (NSAIDs) in river water. Extraction was achieved by a liquid‐phase extraction procedure using methylene chloride. The extract was reacted for 30 min at 80°C based on the formation of methyl ester with 1.0 M HCl in methanol and extraction of the derivative with ethyl acetate, which was then measured by gas chromatography‐mass spectrometry. The limit of quantification of NSAIDs was 1.0–60 ng/L and the calibration curve showed linearity being greater than r=0.997. The method was used to analyze ten river water samples from various regions in Korea. Diclofenac, indoprofen, ketoprofen and loxoprofen were detected at concentration of up to 1.29 μg/L in river water. The developed method may prove valuable for use in the national monitoring project of NSAIDs in surface water.
Preparation and evaluation of thermally stable nano‐structured self‐doped polythiophene coating for analysis of phthalate ester trace levels
Authors: Mehdinia Ali , Bashour Farzane , Roohi Fateme , Jabbari Ali , Saleh Abolfazl 
Published: January 2012

AbstractNano‐structured self‐doped polythiophene (SPT) electrodeposited in the presence of fluorinated organic acid was applied as a thermally stable conductive polymer‐based solid‐phase microextraction (SPME) fiber candidate. Quantitative determination of trace levels of phthalate esters including dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), and diethylhexyl phthalate (DEHP) was carried out using this novel fiber, coupling with gas chromatography‐flame ionization detector (GC‐FID). The SPT coating was proved to be stable at high temperatures (∼350°C) with a high extraction capacity and long lifetime (more than 60 times). Improved temperature resistance was obtained by the presence of sulfonated groups in the backbone of polymer. Thermal stability of novel SPT was superior to common polythiophene (synthesized in LiClO4). The extraction procedure was optimized by means of the Taguchi orthogonal array experimental design with an OA16 (45) matrix including extraction temperature, extraction time, salt concentration, stirring rate, and headspace volume. The good linearity was obtained for most compounds with correlation coefficients (R2) of between 0.993 and 0.995. The detection limits were lower than 0.12 ng/mL for dimethyl phthalate, DEP, dibutyl phthalate, and diethylhexyl phthalate. The method was successfully applied to the analysis of water samples with the recoveries from 90±1 to 107±1%.
Molecularly imprinted polymer surfaces as solid‐phase extraction sorbents for the extraction of 2‐nitrophenol and isomers from environmental water
Authors: Guan Wei , Han Changri , Wang Xue , Zou Xiaohua , Pan Jianming , Huo Pengwei , Li Chunxiang 
Published: January 2012

AbstractThe novel surface molecularly imprinted polymer (MIP) with 2‐nitrophenol (2‐NP) as the template has been prepared and used as the adsorbent for the solid‐phase extraction (SPE). The selectivity of the polymer was checked toward several selected nitrophenols (NPs) such as 2‐NP, 3‐nitrophenol (3‐NP), 4‐nitrophenol (4‐NP) and 2,4,6‐trichlorophenol (2,4,6‐TCP). Under the optimized conditions, high sensitivity (detection limits: 0.07–0.12 ng/mL) and good reproducibility of analytes (2.3–4.8% for four cycles) were achieved. Then, the method was applied for the analysis of selected phenols in spiked tap, lake and river water samples. High recoveries (>83.3%) for nitrophenols (NPs) were obtained, but lower recoveries (<63.4%) were achieved for 2,4,6‐TCP. The method was found to be linear in the range of 1–300 ng/mL with correlation coefficients (R2) greater than 0.99 and repeatability relative standard deviation (RSD) below 7.2% in all cases. For analysis of 120 mL water samples, the method detection limits (LODs) ranged from 0.10 to 0.22 ng/mL and the limit of quantification (LOQs) from 0.33 to 0.72 ng/mL. These results showed the suitability of the MIP‐SPE method for the selective extraction of a group of structurally related isomeric compounds.
Application of ultra‐performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription
Authors: Jiang Haiqiang , Nie Lei , Li Yunlun , Xie Jun 
Published: January 2012

AbstractThis study describes the metabonomic characters of the spontaneously hypertensive rats (SHR) and intervention effects of Ping Gan prescription. Ultra performance LC coupled with Q‐TOF MS (UPLC/MS‐Q‐TOF) was employed to develop a metabonomic method of the plasma of SHR. There was a significant difference in metabolic profiling observed between predose group of Wistar Kyoto rats and model group (SHR) by using the principal components analysis (PCA). Some significant changes in metabolites such as LysoPC(22:6), LysoPC(20:4), LysoPC(18:1), cholylglycine, PE(P‐16:0e/0:0), sphingosine‐1‐phosphate, and 2‐oxo‐4‐methylthio butanoic acid were identified. These biochemical changes were associated with the disturbance in sphingolipid metabolism and fat metabolism, which would be helpful to further understand the essence of hypertension and the therapeutic mechanism of Ping Gan prescription. This study suggests that the metabonomic method may be a valuable and feasible tool to explore the therapeutic effect and mechanism of traditional Chinese medicine (TCM).
Simultaneous determination of polyphenols and major purine alkaloids in Greek Sideritis species, herbal extracts, green tea, black tea, and coffee by high‐performance liquid chromatography‐diode array detection
Authors: Samanidou Victoria , Tsagiannidis Anastasios , Sarakatsianos Ioannis 
Published: January 2012

AbstractHerein, a high‐performance liquid chromatography‐diode array detection method has been developed for the simultaneous determination of 15 phenolic antioxidants: flavan‐3‐ols, (−)‐epigallocatechin, (+)‐catechin, (−)‐epigallocatechin gallate, (−)‐epicatechin, (−)‐epicatechin gallate, (−)‐gallocatechin, a phenolic acid (gallic acid), a hydroxycinnamic acid (chlorogenic acid), flavones (apigenin), flavonols (kaempferol, quercetin, and myricetin), and purine alkaloids (caffeine theophylline, theobromine) in different herb extracts, tea, and coffee varieties. The developed method was validated and successfully applied in order to determine the polyphenolic content to estimate the antioxidant activity of the Sideritis species commonly known as Greek mountain tea. To the best of our knowledge, this is the first report on the quantitative determination of catechins and other polyphenols in Greek mountain tea. Acidic hydrolysis was necessary for the simultaneous determination of the aglycones of the target analytes. According to our results, chlorogenic acid, myricetin, apigenin, catechin, and epicatechin gallate are found in the Sideritis species.
Quantitative structure–retention relationship of curcumin and its analogues
Authors: Zheng Xue‐Hua , Shao Yong‐Xian , Li Zhe , Liu Ming , Bu Xianzhang , Luo Hai‐Bin , Hu Xiaopeng 
Published: January 2012

AbstractThe natural product curcumin is widely used in Asian countries for the treatment of several diseases. However, the clinical potential of curcumins remains limited due to their relatively poor bioavailability and no experimental data about their lipophilicity for bioavailability prediction. To evaluate the retention and lipophilicity of curcumin and its 31 newly synthesized analogues, they were subjected to 3D quantitative structure–retention relationship studies by RP‐HPLC. Superior than the classical four‐variant quantitative structure–retention relationship model (conventional r2=0.734), the 3D comparative molecular similarity index analysis model with combined steric, electrostatic, and H‐bond donor fields, resulted in a robust structure–retention correlation (cross‐validated q2=0.613 and r2=0.979). The statistical analyses indicate that the electrostatic and H‐bond donor fields have a primary influence on the chromatographic retention of analytes. The predictive power and robustness of the derived comparative molecular similarity index analysis model was further confirmed by the test‐set validation (q2=0.702, r2=0.905, and the slope K=1.016) and Y‐randomization examination. Statistically significant and physically meaningful 3D‐quantitative structure–retention relationship provided better insight into understanding the retention behaviors of curcumin and its analogues, and their separation mechanism in a given RP‐HPLC system.
Micropatterns of Non‐Circular Droplets of Nanostructured PS‐b‐PEO Copolymer by Solvent‐Assisted Wetting on a Chemically Periodic Surface
Authors: Kim Tae Hee , Park Youn Jung , Song Giyoung , Kim Dong Ha , Huh June , Karthaus Olaf , Park Cheolmin 
Published: January 2012

AbstractA method to fabricate micropatterns of non‐circular droplets of a self‐assembled block copolymer by solvent‐assisted wetting on chemically periodic surface is presented. The block copolymer is dewetted on a topographic pre‐pattern to form an array of microdroplets with a sphere‐capped shape and circular contact line. The droplets are then transferred onto a chemically periodic Au line pattern microcontact‐printed with two types of self‐assembled monolayers (SAMs). Solvent vapor application provides sufficient mobility to the block copolymer molecules to induce spreading of the transferred droplets, resulting in two types of non‐circular microdroplet growth. The growth behavior depends on the size of initial droplets relative to periodic line width and on the initial registries of as‐transferred droplets.
Poly(disubstituted acetylene)s With Pendant Naphthalimide‐Based Fluorophore Groups
Authors: Sivkova Radoslava , Vohlídal Jiří , Bláha Michal , Svoboda Jan , Sedláček Jan , Zedník Jiří 
Published: January 2012

AbstractNew stable polyacetylenes whose quantum yield of fluorescence is increased up to 62% because of the presence of pendant 4‐(piperidine‐1‐yl)‐1,8‐naphtalimide groups are described. The polymers are prepared by two‐step modification of copolymers of 1‐(4‐tert‐butylphenyl)‐6‐chlorohex‐1‐yne and 1‐phenylhex‐1‐yne consisting of the exchange of chlorine atoms at side groups for azide groups and subsequent Huisgen click reaction of the azide groups with ethynyl groups of N‐(prop‐1‐yne‐3‐yl)‐4‐(piperidine‐1‐yl)‐1,8‐naphthalimide. Modification is evidenced by 1H NMR, IR, Raman and UV–vis spectroscopy. Modified polymers show the excitation energy transfer from their main chains on fluorophores and nearly preservation of fluorescence properties of fluorophores upon their binding to polymer chains.
Are the psychological needs of adolescent survivors of pediatric cancer adequately identified and treated?
Authors: Kahalley Lisa S. , Wilson Stephanie J. , Tyc Vida L. , Conklin Heather M. , Hudson Melissa M. , Wu Shengjie , Xiong Xiaoping , Stancel Heather H. , Hinds Pamela S. 
Published: January 2012

AbstractObjectivesTo describe the psychological needs of adolescent survivors of acute lymphoblastic leukemia (ALL) or brain tumor (BT), we examined the following: (i) the occurrence of cognitive, behavioral, and emotional concerns identified during a comprehensive psychological evaluation and (ii) the frequency of referrals for psychological follow‐up services to address identified concerns.MethodsPsychological concerns were identified on measures according to predetermined criteria for 100 adolescent survivors. Referrals for psychological follow‐up services were made for concerns previously unidentified in formal assessment or not adequately addressed by current services.ResultsMost survivors (82%) exhibited at least one concern across domains: behavioral (76%), cognitive (47%), and emotional (19%). Behavioral concerns emerged most often on scales associated with executive dysfunction, inattention, learning, and peer difficulties. Cranial radiation therapy was associated with cognitive concerns, χ2(1, N = 100) = 5.63, p < 0.05. Lower income was associated with more cognitive concerns for ALL survivors, t(47) = 3.28, p < 0.01, and more behavioral concerns for BT survivors, t(48) = 2.93, p < 0.01. Of the survivors with concerns, 38% were referred for psychological follow‐up services. Lower‐income ALL survivors received more referrals for follow‐up, χ2(1, N = 41) = 8.05, p < 0.01. Referred survivors had more concerns across domains than non‐referred survivors, ALL: t(39) = 2.96, p < 0.01; BT: t(39) = 3.52, p < 0.01. Trends suggest ALL survivors may be at risk for experiencing unaddressed cognitive needs.ConclusionsMany adolescent survivors of cancer experience psychological difficulties that are not adequately managed by current services, underscoring the need for long‐term surveillance. In addition to prescribing regular psychological evaluations, clinicians should closely monitor whether current support services appropriately meet survivors' needs, particularly for lower‐income survivors and those treated with cranial radiation therapy. Copyright © 2012 John Wiley & Sons, Ltd.