bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reforms and innovations in primary health care in different countries: scoping review
Authors: Azimzadeh Solmaz , Azami-Aghdash Saber , Tabrizi Jafar Sadegh , Gholipour Kamal 
Published: April 2024

Abstract

Introduction:
The World Health Organization (WHO) recommends focusing on primary health care (PHC) as the first strategy of countries to achieve the improvement of the health level of communities and has emphasized it again in 2021. Therefore, we intend to take a different look at the PHC system with reform, innovation, and initiative by using the experiences of leading countries and identify practical and evidence-based solutions to achieve greater health.

Methods:
This is a scoping review study that has identified innovations and reforms related to PHC since the beginning of 2000 to the end of 2022. In this study, Scopus, Web Of Science, and PubMed databases have been searched using appropriate keywords. This study is done in six steps using Arkesy and O’Malley framework. In this study, the framework of six building blocks of WHO was used to summarize and report the findings.

Results:
By searching in different databases, we identified 39426 studies related to reforms in primary care, and after the screening process, 106 studies were analyzed. Our findings were classified and reported into 9 categories (aims, stewardship/leadership, financing & payment, service delivery, health workforce, information, outcomes, policies/considerations, and limitations).

Conclusion:
The necessity and importance of strengthening PHC is obvious to everyone due to its great consequences, which requires a lot of will, effort, and coordination at the macro-level of the country, various organizations, and health teams, as well as the participation of people and society.
Evaluating the Role of Titanomagnetite in Bubble Nucleation: Novel Applications of Low Temperature Magnetic Analysis and Textural Characterization of Rhyolite Pumice and Obsidian From Glass Mountain, California
Authors: McCartney Kelly N. , Hammer Julia E. , Shea Thomas , Brachfeld Stefanie , Giachetti Thomas 
Published: April 2024

AbstractNucleation of H2O vapor bubbles in magma requires surpassing a chemical supersaturation threshold via decompression. The threshold is minimized in the presence of a nucleation substrate (heterogeneous nucleation, <50 MPa), and maximized when no nucleation substrate is present (homogeneous nucleation, >100 MPa). The existence of explosively erupted aphyric rhyolite magma staged from shallow (<100 MPa) depths represents an apparent paradox that hints at the presence of a cryptic nucleation substrate. In a pair of studies focusing on Glass Mountain eruptive units from Medicine Lake, California, we characterize titanomagnetite nanolites and ultrananolites in pumice, obsidian, and vesicular obsidian (Brachfeld et al., 2024, https://doi.org/10.1029/2023GC011336), calculate titanomagnetite crystal number densities, and compare titanomagnetite abundance with the physical properties of pumice to evaluate hypotheses on the timing of titanomagnetite crystallization. Titanomagnetite crystals with grain sizes of approximately 3–33 nm are identified in pumice samples from the thermal unblocking of low‐temperature thermoremanent magnetization. The titanomagnetite number densities for pumice are 1018 to 1020 m−3, comparable to number densities in pumice and obsidian obtained from room temperature methods (Brachfeld et al., 2024, https://doi.org/10.1029/2023GC011336). This range exceeds reported bubble number densities (BND) within the pumice from the same eruptive units (average BND ∼4 × 1014 m−3). The similar abundances of nm‐scale titanomagnetite crystals in the effusive and explosive products of the same eruption, together with the lack of correlation between pumice permeability and titanomagnetite content, are consistent with titanomagnetite formation having preceded the bubble formation. Results suggest sub‐micron titanomagnetite crystals are responsible for heterogeneous bubble nucleation in this nominally aphyric rhyolite magma.
Middle Neoproterozoic (Tonian) Polar Wander of South China: Paleomagnetism and ID‐TIMS U‐Pb Geochronology of the Laoshanya Formation
Authors: Tonti‐Filippini Justin A. D. , Robert Boris , Muller Élodie , Paul André N. , Dellefant Fabian , Wack Michael , Meng Jun , Zhao Xixi , Schaltegger Urs , Gilder Stuart A. 
Published: April 2024

AbstractPaleomagnetic records of middle Neoproterozoic (820 to 780 Ma) rocks display high amplitude directional variations that lead to large discrepancies in paleogeographic reconstructions. Hypotheses to explain these data include rapid true polar wander (TPW), a geomagnetic field geometry that deviates from a predominantly axial dipole field, a hyper‐reversing field (>10 reversals/Ma), and/or undiagnosed remagnetization. To test these hypotheses, we collected 1,057 oriented cores over a 85 m stratigraphic succession in the Laoshanya Formation (Yangjiaping, Hunan, China). High precision U‐Pb dating of two intercalated tuff layers constrain the age of the sediments between 809 and 804 Ma. Thermal demagnetization isolates three magnetization components residing in hematite which are not time‐progressive but conflated throughout the section. All samples possess a north and downward directed component in geographic coordinates at temperatures up to 660°C that is ascribed to a Cretaceous overprint. Two components isolated above 660°C reveal distinct directional clusters: one is interpreted as a depositional remanence, while the other appears to be the result of a mid‐Paleozoic (460 to 420 Ma) remagnetization, which is likely widespread throughout South China. The high‐temperature directions are subtly dependent on lithology; microscopic and rock magnetic analyses identify multiple generations of hematite that vary in concentration and distinguish the magnetization components. A comparison with other middle Neoproterozoic paleomagnetic studies in the region indicates that the sudden changes in paleomagnetic directions, used elsewhere to support the rapid TPW hypothesis (ca. 805 Ma), are better explained by mixtures of primary and remagnetized components, and/or vertical axis rotations.
Deciphering Clues Regarding Magma Composition Encoded in Quartz‐Hosted Embayments and Melt Inclusions Through Direct Numerical Simulations
Authors: Wei Zihan , Ruefer Anna C. , Pamukcu Ayla S. , Suckale Jenny 
Published: April 2024

AbstractCrystal‐hosted melt embayments and melt inclusions partially record magmatic processes at depth, but it is not always obvious how to interpret this record. One impediment is our incomplete understanding of how embayments and melt inclusions form. In this study, we investigate the formation mechanism of embayments and melt inclusions during quartz growth to quantify the relationship between the compositions of the entrapped and average melt. We study the growth of embayments and inclusions through direct numerical simulations that couple the growth of a crystal surface with the evolution of the concentrations of incompatible components in the surrounding melt. We find that H2O is more enriched in the interior of defects on crystal surface compared to the exterior. The resultant lower disequilibrium in the defect interior causes lower growth rate than in the exterior, elongating the defect into an embayment. If crystal growth stops, the composition in the embayment equilibrates with the average melt within days to months. If crystal growth continues until the embayment neck closes, a melt inclusion forms. The melt entrapped by both embayments and melt inclusions is enriched in incompatible components, such as H2O and CO2. In addition to inclusion size, the enrichment of incompatible components in melt inclusions also depends on component diffusivity and the crystal growth regime. High‐diffusivity components like H2O have similar enrichment levels in all scenarios, while lower‐diffusivity components like CO2 are more enriched in melt inclusions with smaller sizes or formed in continuous crystal growth.
Insights Into the Structure of the Mongol‐Okhotsk Suture Zone, Adaatsag Ophiolite, and Tectonic Boundaries of the Central Asian Orogenic Belt (Mongolia) From Electrical Resistivity Imaging and Seismic Velocity Models
Authors: Comeau Matthew J. , Rigaud Rafael , Batmagnai Erdenechimeg , Tserendug Shoovdor , Kuvshinov Alexey , Becken Michael , Demberel Sodnomsambuu 
Published: April 2024

AbstractThe Mongol‐Okhotsk suture and the Adaatsag ophiolite belt are associated with the closure of the Mongol‐Okhotsk paleo‐ocean and are located within the Central Asian Orogenic Belt (CAOB) and Mongolia. The suture zone is flanked by volcanic‐plutonic belts that host significant metallogenic zones, containing deposits of copper and gold. The tectonic evolution of this region is not fully understood and the lithospheric structure has been poorly studied. We analyze magnetotelluric data and generate a model of the electrical resistivity distribution across this region. Whereas the northern segment has a sharp transition from a high‐resistivity upper crust to a low‐resistivity lower crust, as observed beneath the Hangai Dome, the southern segment does not show this transition. A wide, low‐resistivity zone (1–100 Ωm) imaged in the crust and lithospheric mantle is coincident with the Mongol‐Okhotsk suture and ophiolite, revealing a clear and significant lithospheric‐scale feature. Across the profile, numerous narrow, vertically oriented, low‐resistivity features (1–100 Ωm) are spatially associated remarkably well with the proposed boundaries of tectonic domains. These results confirm ideas about the development of the CAOB. Some of these low‐resistivity features are beneath the surface locations of large mineral zones, and likely represent fossil fluid pathways. We show congruent seismic velocity models for comparison and the results show a large‐scale low‐velocity anomaly (decrease of 2%–3%) that correlates with the location of the low‐resistivity anomaly below the Mongol‐Okhotsk suture. The geophysical results, combined with geological and geochemical data, provide insights into the structure of this region and help shed light on unanswered questions.
Revisiting the Tianwen Yellow Pumice (TYP) Eruption of Changbaishan Volcano: Tephra Correlation, Eruption Timing and Its Climatostratigraphical Context
Authors: Chen Xuan‐Yu , Xu Yi‐Gang , Tarasov Pavel E. , Leipe Christian , Kim Ji‐Hoon , Yan Shuang , Park Myong‐Ho , Chun Jong‐Hwa , Chen Cong , He Peng‐Li , Blockley Simon P. E. 
Published: April 2024

AbstractChangbaishan volcano (China/North Korea) is one of the most active and hazardous volcanic centers in Northeast Asia. Despite decades of intensive research, the eruption history of this stratovolcano remains poorly constrained. One of the major puzzles is the timing of the eruption that produced the Tianwen Yellow Pumice (TYP) deposit at the caldera rim. Here we identify a new cryptotephra layer in sediment core 13PT‐P4 from the East Sea. Grain‐specific major, minor, and trace element analyses of glass shards allow a clear correlation of this distal tephra to the proximal TYP deposit of Changbaishan. Age‐depth modeling using radiocarbon (14C) dates of sediment bulk organic fractions and other tephrochronological markers from the sediment sequence constraints the age of the cryptotephra and thus the TYP eruption to 29,948–29,625 cal yr BP (95.4% confidence interval). Our findings lead to a revision of the history of Changbaishan explosive activity, and show that the volcano has been particularly active during ca. 51–24 ka BP in the last 100 ka. Using high resolution palaeo‐proxy records, we find the TYP tephra almost coeval with regional to hemispheric‐scale climatic changes known as Heinrich Event 3 (H3). With its precise age determination and wide geographic dispersion, the tephra offers a key isochron for dating records of past climatic changes and addressing the phasing relationships in environmental response to H3 across East Asia.
Three‐Dimensional Modeling of the O2(1∆) Dayglow: Dependence on Ozone and Temperatures
Authors: Diouf Mouhamadou Makhtar Ndiaga , Lefèvre Franck , Hauchecorne Alain , Bertaux Jean‐Loup 
Published: April 2024

AbstractFuture space missions dedicated to measuring CO2 on a global scale can make advantageous use of the O2 band at 1.27 μm to retrieve the air column. The 1.27 μm band is close to the CO2 absorption bands at 1.6 and 2.0 μm, which allows a better transfer of the aerosol properties than with the usual O2 band at 0.76 μm. However, the 1.27 μm band is polluted by the spontaneous dayglow of the excited state O2 (1∆), which must be removed from the observed signal. We investigate here our quantitative understanding of the O2(1∆) dayglow with a chemistry‐transport model. We show that the previously reported −13% deficit in O2(1∆) dayglow calculated with the same model is essentially due a −20% to −30% ozone deficit between 45 and 60 km. We find that this ozone deficit is due to excessively high temperatures (+15 K) of the meteorological analyses used to drive the model in the mesosphere. The use of lower analyzed temperatures (ERA5), in better agreement with the observations, slows down the hydrogen‐catalyzed and Chapman ozone loss cycles. This effect leads to an almost total elimination of the ozone and O2(1∆) deficits in the lower mesosphere. Once integrated vertically to simulate a nadir measurement, the deficit in modeled O2(1∆) brightness is reduced to −4.2 ± 2.8%. This illustrates the need for accurate mesospheric temperatures for a priori estimations of the O2(1∆) brightness in algorithms using the 1.27 μm band.
Empirical Models of foF2 and hmF2 Reconstituted by Global Ionosonde and Reanalysis Data and COSMIC Observations
Authors: Huang Fuqing , Ruan Haibing , Lei Jiuhou , Zhong Jiahao , Yue Xinan , Li Guozhu , Chen Yiding , He Jianhui , Li Na , Luan Xiaoli , Xiong Chao , Dou Xiankang 
Published: April 2024

AbstractThe F2‐peak plasma frequency (foF2) and the height of the F2 peak (hmF2) are two of the most important parameters for any ionospheric model, as well as radio propagation studies and applications. In this study, we have developed empirical models to capture the most significant variations of foF2 and hmF2. The derived empirical models (referred to as the USTC models within this study) are specified through global ionosonde and reanalysis data based on the International Reference Ionosphere (IRI) Consultative Committee on International Radio (CCIR) method and Constellation Observindg System for Meteorology, Ionosphere, and Climate (COSMIC) observations based on the empirical orthogonal function analysis, respectively. The USTC models are validated against the IRI CCIR model prediction. The comparison results revealed that the empirical foF2 model performs better in capturing the foF2 variations than the IRI CCIR model, which can overcome the underestimation of the IRI CCIR model at low latitudes. Although the IRI CCIR model overestimation at middle latitudes is addressed by the empirical hmF2 model, the visible differences between the model predictions and ionosonde observations still exist at low latitudes, which could be attributed to the significant difference between COSMIC and ionosonde hmF2 measures.
Developing a geographical–meteorological indicator system and evaluating prediction models for alveolar echinococcosis in China
Authors: Xue Chuizhao , Liu Baixue , Kui Yan , Wu Weiping , Zhou Xiaonong , Xiao Ning , Han Shuai , Zheng Canjun 
Published: April 2024

Abstract
Background
Geographical and meteorological factors have been reported to influence the prevalence of echinococcosis, but there’s a lack of indicator system and model.

Objective
To provide further insight into the impact of geographical and meteorological factors on AE prevalence and establish a theoretical basis for prevention and control.

Methods
Principal component and regression analysis were used to screen and establish a three-level indicator system. Relative weights were examined to determine the impact of each indicator, and five mathematical models were compared to identify the best predictive model for AE epidemic levels.

Results
By analyzing the data downloaded from the China Meteorological Data Service Center and Geospatial Data Cloud, we established the KCBIS, including 50 basic indicators which could be directly obtained online, 15 characteristic indicators which were linear combination of the basic indicators and showed a linear relationship with AE epidemic, and 8 key indicators which were characteristic indicators with a clearer relationships and fewer mixed effects. The relative weight analysis revealed that monthly precipitation, monthly cold days, the difference between negative and positive temperature anomalies, basic air temperature conditions, altitude, the difference between positive and negative atmospheric pressure anomalies, monthy extremely hot days, and monthly fresh breeze days were correlated with the natural logarithm of AE prevalence, with sequential decreases in their relative weights. The multinomial logistic regression model was the best predictor at epidemic levels 1, 3, 5, and 6, whereas the CART model was the best predictor at epidemic levels 2, 4, and 5.
Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia
Authors: Peng Hao , Xin Shan , Pfeiffer Susanne , Müller Constanze , Merl-Pham Juliane , Hauck Stefanie M. , Harter Patrick N. , Spitzer Daniel , Devraj Kavi , Varynskyi Borys , Arzberger Thomas , Momma Stefan , Schick Joel A. 
Published: April 2024

AbstractThe progression of human degenerative and hypoxic/ischemic diseases is accompanied by widespread cell death. One death process linking iron-catalyzed reactive species with lipid peroxidation is ferroptosis, which shows hallmarks of both programmed and necrotic death in vitro. While evidence of ferroptosis in neurodegenerative disease is indicated by iron accumulation and involvement of lipids, a stable marker for ferroptosis has not been identified. Its prevalence is thus undetermined in human pathophysiology, impeding recognition of disease areas and clinical investigations with candidate drugs. Here, we identified ferroptosis marker antigens by analyzing surface protein dynamics and discovered a single protein, Fatty Acid-Binding Protein 5 (FABP5), which was stabilized at the cell surface and specifically elevated in ferroptotic cell death. Ectopic expression and lipidomics assays demonstrated that FABP5 drives redistribution of redox-sensitive lipids and ferroptosis sensitivity in a positive-feedback loop, indicating a role as a functional biomarker. Notably, immunodetection of FABP5 in mouse stroke penumbra and in hypoxic postmortem patients was distinctly associated with hypoxically damaged neurons. Retrospective cell death characterized here by the novel ferroptosis biomarker FABP5 thus provides first evidence for a long-hypothesized intrinsic ferroptosis in hypoxia and inaugurates a means for pathological detection of ferroptosis in tissue.
An isolable, chelating bis[cyclic (alkyl)(amino)carbene] stabilizes a strongly bent, dicoordinate Ni(0) complex
Authors: Puerta Lombardi Braulio M. , Faas Morgan R. , West Daniel , Suvinen Roope A. , Tuononen Heikki M. , Roesler Roland 
Published: April 2024

AbstractChelating ligands have had a tremendous impact in coordination chemistry and catalysis. Notwithstanding their success as strongly σ-donating and π-accepting ligands, to date no chelating bis[cyclic (alkyl)(amino)carbenes] have been reported. Herein, we describe a chelating, C2-symmetric bis[cyclic (alkyl)(amino)carbene] ligand, which was isolated as a racemic mixture. The isolation and structural characterization of its isostructural, pseudotetrahedral complexes with iron, cobalt, nickel, and zinc dihalides featuring eight-membered metallacycles demonstrates the binding ability of the bis(carbene). Reduction of the nickel(II) dibromide with potassium graphite produces a dicoordinate nickel(0) complex that features one of the narrowest angles measured in any unsupported dicoordinate transition metal complexes.
Highly defective ultra-small tetravalent MOF nanocrystals
Authors: Dai Shan , Simms Charlotte , Patriarche Gilles , Daturi Marco , Tissot Antoine , Parac-Vogt Tatjana N. , Serre Christian 
Published: April 2024

AbstractThe size and defects in crystalline inorganic materials are of importance in many applications, particularly catalysis, as it often results in enhanced/emerging properties. So far, applying the strategy of modulation chemistry has been unable to afford high-quality functional Metal–Organic Frameworks (MOFs) nanocrystals with minimized size while exhibiting maximized defects. We report here a general sustainable strategy for the design of highly defective and ultra-small tetravalent MOFs (Zr, Hf) crystals (ca. 35% missing linker, 4–6 nm). Advanced characterizations have been performed to shed light on the main factors governing the crystallization mechanism and to identify the nature of the defects. The ultra-small nanoMOFs showed exceptional performance in peptide hydrolysis reaction, including high reactivity, selectivity, diffusion, stability, and show emerging tailorable reactivity and selectivity towards peptide bond formation simply by changing the reaction solvent. Therefore, these highly defective ultra-small M(IV)-MOFs particles open new perspectives for the development of heterogeneous MOF catalysts with dual functions.
Strong linkage between benthic oxygen uptake and bacterial tetraether lipids in deep-sea trench regions
Authors: Xiao Wenjie , Xu Yunping , Canfield Donald E. , Wenzhöfer Frank , Zhang Chuanlun , Glud Ronnie N. 
Published: April 2024

AbstractOxygen in marine sediments regulates many key biogeochemical processes, playing a crucial role in shaping Earth’s climate and benthic ecosystems. In this context, branched glycerol dialkyl glycerol tetraethers (brGDGTs), essential biomarkers in paleoenvironmental research, exhibit an as-yet-unresolved association with sediment oxygen conditions. Here, we investigated brGDGTs in sediments from three deep-sea regions (4045 to 10,100 m water depth) dominated by three respective trench systems and integrated the results with in situ oxygen microprofile data. Our results demonstrate robust correlations between diffusive oxygen uptake (DOU) obtained from microprofiles and brGDGT methylation and isomerization degrees, indicating their primary production within sediments and their strong linkage with microbial diagenetic activity. We establish a quantitative relationship between the Isomerization and Methylation index of Branched Tetraethers (IMBT) and DOU, suggesting its potential validity across deep-sea environments. Increased brGDGT methylation and isomerization likely enhance the fitness of source organisms in deep-sea habitats. Our study positions brGDGTs as a promising tool for quantifying benthic DOU in deep-sea settings, where DOU is a key metric for assessing sedimentary organic carbon degradation and microbial activity.