bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial distribution and environmental correlations of Culex pipiens pallens (Diptera: Culicidae) in Haidian district, Beijing
Authors: Liu Meide , Zhang Yong , Li Qiuhong , Zhou Xiaojie , Yan Ting , Li Jing , Zhang Hongjiang , Wang Lei , Wang Guangwen , Li Ruoxi , Tong Ying , Zeng Xiaopeng 
Published: May 2024

Abstract
Culex pipiens pallens Coquillett, 1898 (Diptera: Culicidae) was the dominant health threat to mosquito species in Beijing, and it is important to unravel the spatial distribution and environmental correlations of Cx. pipiens pallens in Beijing. 3S technology methods and spatial statistics were used to clarify the distribution pattern. Subsequently, linear and spatial regression were performed to detect the environmental factors linked with the density of Cx. pipiens pallens. The same “middle peak” spatial distribution pattern was observed for Cx. pipiens pallens density at the community, subdistrict, and loop area levels in our study area. In addition, there were various correlated environmental factors at the community and subdistrict scales. At the community scale, the summary values of the Modified Normalized Difference Water Index (MNDWI) in 2 km buffer zone (MNDWI_2K) were negatively correlated, and the summary values of Normalized Difference Built-up Index (NDBI) in 800 m buffer zone (NDBI_800) was positively correlated to the Cx. pipiens pallens density. However, the summary values of Normalized Difference Vegetation Index and Nighttime Light Index significantly affected Cx. pipiens pallens density at the subdistrict scale. Our findings provide insight into the spatial distribution pattern of Cx. pipiens pallens density and its associated environmental risk factors at different spatial scales in the Haidian district of Beijing for the first time. The results could be used to predict the Cx. pipiens pallens density as well as the risk of lymphatic filariasis (LF) infection, which would help implement prevention and control measures to prevent future risks of biting and LF transmission in Beijing.
An antihalo void catalogue of the Local Super-Volume
Authors: Stopyra Stephen , Peiris Hiranya V , Pontzen Andrew , Jasche Jens , Lavaux Guilhem 
Published: May 2024

ABSTRACT
We construct an antihalo void catalogue of 150 voids with radii $R \gt 10\, h^{-1}\mathrm{\, Mpc}$ in the Local Super-Volume ($\lt 135\, h^{-1}\mathrm{\, Mpc}$ from the Milky Way), using posterior resimulation of initial conditions inferred by field-level inference with Bayesian Origin Reconstruction from Galaxies (borg). We describe and make use of a new algorithm for creating a single, unified void catalogue by combining different samples from the posterior. The catalogue is complete out to $135\, h^{-1}\mathrm{\, Mpc}$, with void abundances matching theoretical predictions. Finally, we compute stacked density profiles of those voids which are reliably identified across posterior samples, and show that these are compatible with Λ cold dark matter expectations once environmental selection (e.g. the estimated $\sim 4{{\ \rm per\ cent}}$ underdensity of the Local Super-Volume) is accounted for.
The first low-mass eclipsing binary within the fully convective zone from TMTS
Authors: Liu Cheng , Wang Xiaofeng , Zhang Xiaobing , Kovalev Mikhail , Lin Jie , Xi Gaobo , Mo Jun , Li Gaici , Peng Haowei , Li Xin , Xia Qiqi , Iskandar Abdusamatjan , Zeng Xiangyun , Wang Letian , Zhu Liying , Song Xuan , Guo Jincheng , Jiang Xiaojun , Yan Shengyu , Zhang Jicheng 
Published: May 2024

ABSTRACT
We present a comprehensive photometric and spectroscopic analysis of the short-period (∼5.32 h) and low-mass eclipsing binary TMTSJ0803 discovered by Tsinghua-Ma Huateng Telescope for Survey (TMTS). By fitting the light curves and radial velocity data with the Wilson–Devinney code, we find that the binary is composed of two late spotted active M dwarfs below the fully convective boundary. This is supported by the discovery of a significant Balmer emission lines in the LAMOST spectrum and prominent coronal X-ray emission. In comparison with the typical luminosity of rapidly rotating fully convective stars, the much brighter X-ray luminosity (LX/Lbol = 0.0159 ± 0.0059) suggests the stellar magnetic activity of fully convective stars could be enhanced in such a close binary system. Given the metallicity of [M/H] = − 0.35 dex as inferred from the LAMOST spectrum, we measure the masses and radii of both stars to be M1 = 0.169 ± 0.010 M⊙, M2 = 0.162 ± 0.016 M⊙, R1 = 0.170 ± 0.006 R⊙, and R2 = 0.156 ± 0.006 R⊙, respectively. Based on the luminosity ratio from the light-curve modelling, the effective temperatures of two components are also estimated. In comparison with the stellar evolution models, the radii, and effective temperatures of two components are all below the isochrones. The radius deflation might be mainly biased by a small radial velocity (RV) data or (and) a simple correction on RVs, while the discrepancy in effective temperature might be due to the enhanced magnetic activity in this binary.
Efficacy and safety of abatacept for systemic juvenile idiopathic arthritis: A systematic review
Authors: Nishimura Kenichi , Ishikawa Takashi , Okamoto Nami , Akamine Keiji , Inoue Natsumi , Irabu Hitoshi , Kato Kentaro , Keino Hiroshi , Kojima Masayo , Kubo Hiroshi , Maruyama Kazuichi , Mizuta Mao , Shabana Kosuke , Shimizu Masaki , Sugita Yuko , Takakuwa Yukiko , Takanashi Satoshi , Takase Hiroshi , Umebayashi Hiroaki , Umezawa Natsuka , Yamanishi Shingo , Yamazaki Kazuko , Yashiro Masato , Yasumi Takahiro , Mori Masaaki 
Published: May 2024

ABSTRACT

Objectives
This systematic review assessed the efficacy and safety of abatacept in patients with systemic juvenile idiopathic arthritis (JIA).

Methods
Studies published between 2000 and 2021 were searched using PubMed, Embase, Cochrane, Ichushi-Web, and clinical trial registries. The risk of bias was assessed according to the manual for development clinical practice guidelines by Minds, a project to promote evidence-based medicine in Japan.

Results
Seven observational studies were included. American College of Rheumatology pediatric 30/50/70 responses at 3, 6, and 12 months were 64.8%/50.3%/27.9%, 85.7%/71.4%/42.9%, and 80.0%/50.0%/40.0%, respectively. Outcomes on systemic symptoms, joint symptoms, and activities of daily living were not obtained. No macrophage activation syndrome or infusion reaction occurred. Serious infection occurred in 2.6% of cases.

Conclusions
Abatacept improved the disease activity index. In addition, abatacept was as safe as interleukin-6 (IL-6) and IL-1 inhibitors. However, both the efficacy and safety data in this systematic review should be reviewed with caution because their quality of evidence is low or very low. Further studies are needed to confirm the efficacy and safety of abatacept for systemic JIA, especially its efficacy on joint symptoms.
Next generation sequencing technologies to address aberrant mRNA translation in cancer
Authors: Román Ángel-Carlos , Benítez Dixan A , Díaz-Pizarro Alba , Del Valle-Del Pino Nuria , Olivera-Gómez Marcos , Cumplido-Laso Guadalupe , Carvajal-González Jose M , Mulero-Navarro Sonia 
Published: May 2024

Abstract
In this review, we explore the transformative impact of next generation sequencing technologies in the realm of translatomics (the study of how translational machinery acts on a genome-wide scale). Despite the expectation of a direct correlation between mRNA and protein content, the complex regulatory mechanisms that affect this relationship remark the limitations of standard RNA-seq approaches. Then, the review characterizes crucial techniques such as polysome profiling, ribo-seq, trap-seq, proximity-specific ribosome profiling, rnc-seq, tcp-seq, qti-seq and scRibo-seq. All these methods are summarized within the context of cancer research, shedding light on their applications in deciphering aberrant translation in cancer cells. In addition, we encompass databases and bioinformatic tools essential for researchers that want to address translatome analysis in the context of cancer biology.
Medulloblastomas with ELP1 pathogenic variants: A weakly penetrant syndrome with a restricted spectrum in a limited age window
Authors: Guerrini-Rousseau Léa , Masliah-Planchon Julien , Filser Mathilde , Tauziède-Espariat Arnault , Entz-Werle Natacha , Maugard Christine M , Hopman Saskia M J , Torrejon Jacob , Gauthier-Villars Marion , Simaga Fatoumata , Blauwblomme Thomas , Beccaria Kevin , Rouleau Etienne , Dimaria Marina , Grill Jacques , Abbou Samuel , Claret Béatrice , Brugières Laurence , Doz François , Bouchoucha Yassine , Faure-Conter Cécile , Bonadona Valerie , Mansuy Ludovic , de Carli Emilie , Ingster Olivier , Legrand Clémentine , Pagnier Anne , Berthet Pascaline , Bodet Damien , Julia Sophie , Bertozzi Anne-Isabelle , Wilems Marjolaine , Maurage Claude-Alain , Delattre Olivier , Ayrault Olivier , Dufour Christelle , Bourdeaut Franck 
Published: May 2024

Abstract

Background
ELP1 pathogenic variants (PV) have been recently identified as the most frequent variants predisposing to Sonic Hedgehog (SHH) medulloblastomas (MB); however, guidelines are still lacking for genetic counseling in this new syndrome.

Methods
We retrospectively reviewed clinical and genetic data of a French series of 29 ELP1-mutated MB.

Results
All patients developed SHH-MB, with a biallelic inactivation of PTCH1 found in 24 tumors. Other recurrent alterations encompassed the TP53 pathway and activation of MYCN/MYCL signaling. The median age at diagnosis was 7.3 years (range: 3–14). ELP1-mutated MB behave as sporadic cases, with similar distribution within clinical and molecular risk groups and similar outcomes (5 y – OS = 86%); no unusual side effect of treatments was noticed. Remarkably, a germline ELP1 PV was identified in all patients with available constitutional DNA (n = 26); moreover, all tested familial trio (n = 11) revealed that the PVs were inherited. Two of the 26 index cases from the French series had a family history of MB; pedigrees from these patients and from 1 additional Dutch family suggested a weak penetrance. Apart from MB, no cancer was associated with ELP1 PVs; second tumors reported in 4 patients occurred within the irradiation fields, in the usual time-lapse for expected radiotherapy-induced neoplasms.

Conclusions
The low penetrance, the “at risk’ age window limited to childhood and the narrow tumor spectrum, question the actual benefit of genetic screening in these patients and their family. Our results suggest restricting ELP1 germline sequencing to patients with SHH-MB, depending on the parents” request.
Comparison of Tobacco Product Prices at Fort Liberty Army Installation and Surrounding Community Areas, 2021
Authors: Elliott Alison M , Kong Amanda Y , McGuirt Jared , Prentice-Dunn Hannah , Gougler-Reeves Krysta M , Little Melissa A , Ribisl Kurt M 
Published: May 2024

Abstract

Introduction
High rates of tobacco use persist in the U.S. military, with 18.4% of service members smoking cigarettes in 2018. The Department of Defense’s (DoD) 2017 policy required that tobacco retailers on military installations set tobacco product prices equal to the most common community price, including tax, but there is limited evidence confirming whether local retailers are adhering to this policy. We examined tobacco product pricing in tobacco retailers on- and off-post at the largest U.S. Army installation, Fort Liberty, and Cumberland County, North Carolina.

Aims and Methods
Between June and August 2021, we collected data on tobacco product availability, price, and promotions from retailers on Fort Liberty (n = 14) and a random sample of off-post retailers within 10 miles of installation gates (n = 52). We calculated the mode, mean, and median price of each product, plus the difference in these prices at on- and off-post retailers. We used Welch’s t-test to test differences in mean prices between on- versus off-post retailers.

Results
The mode, mean, and median prices of cigarette packs and cartons were lower on-post than off-post (eg, $0.51–$0.55 cheaper for Marlboro cigarette packs on-post). However, the mode, mean, and median prices of smokeless tobacco products and little cigars were higher on-post than off-post (eg, $0.82–$0.89 more costly for Swisher Sweets 2-packs on-post).

Conclusions
Results highlight the need for continued enforcement to ensure compliance with the 2017 DoD policy. Comprehensive policy action to reduce tobacco price disparities on- and off-post is critical to reducing high rates of tobacco use among service members.

Implications
Despite the implementation of the 2017 DoD pricing policy, some tobacco products remain cheaper at tobacco retailers on-post compared to off-post retailers. Our results highlight the need for greater routine surveillance to increase implementation of the policy—particularly for cigarettes—to reduce high rates of tobacco use among service members.
Attitudes and Exposure to Illicit Tobacco in England, 2022
Authors: Davies Nathan , Langley Tessa , Jayes Leah , Bains Manpreet , Brown Jamie , Arnott Deborah , Bogdanovica Ilze 
Published: May 2024

Abstract

Introduction
The United Kingdom has achieved reductions in illicit tobacco (IT) market size and share. However, there remains a 17.7% tobacco duty gap, contributing to health inequalities. In January 2024, the UK government announced a new strategy to control IT, along with provision of new funding.

Methods
A representative cross-sectional survey of adults in England ran in April 2022 to evaluate attitudes and exposure to IT. Tobacco smokers were asked questions about encounters with IT, while all participants answered questions on knowledge and perspectives on IT.

Results
Of 262 tobacco smokers, 18.3% (95% CI 13.8% to 23.6%) had come across IT in the past year. Men had four times the odds of encountering IT recently than women. Among 1767 adults responding to questions on IT, two-thirds agreed IT harmed children, and more than half agreed IT was linked to organized crime. Younger adults, smokers, and those in lower socioeconomic groups were less likely to agree IT was harmful.

Conclusions
Exposure to IT, especially among younger males, remains a concern. While most of the public acknowledge its harm, this is not universal, and some population groups are less likely to do so.

Implications
The study highlights persistent exposure to IT in England, especially among younger males, and varying perceptions of IT harm across socioeconomic groups. Tackling IT requires collaboration between health and enforcement agencies, independent of the tobacco industry’s influence. Strategies should include components that shift demand for IT and denormalize its presence in communities, particularly in lower socioeconomic areas with higher smoking prevalence.
Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1
Authors: Diplock Nathan , Baudin Maël , Xiang Xincheng (Derek) , Liang Lung-Yu , Dai Weiwen , Murphy James M , Lucet Isabelle S , Hassan Jana A , Lewis Jennifer D 
Published: May 2024

Abstract
The highly conserved angiosperm immune receptor HOPZ-ACTIVATED RESISTANCE 1 (ZAR1) is a bacterial pathogen recognition hub that mediates resistance by guarding host kinases for modification by pathogen effectors. The pseudokinase HOPZ-ETI DEFICIENT 1 (ZED1) is the only known ZAR1-guarded protein that interacts directly with a pathogen effector, HopZ1a, from the bacterial pathogen Pseudomonas syringae, making it a promising system for rational design of effector recognition for plant immunity. Here, we conducted an in-depth molecular analysis of ZED1. We generated a library of 164 random ZED1 mutants and identified 50 mutants that could not recognize the effector HopZ1a when transiently expressed in Nicotiana benthamiana. Based on our random mutants, we generated a library of 27 point mutants and found evidence of minor functional divergence between Arabidopsis (Arabidopsis thaliana) and N. benthamiana ZAR1 orthologs. We leveraged our point mutant library to identify regions in ZED1 critical for ZAR1 and HopZ1a interactions and identified two likely ZED1-HopZ1a binding conformations. We explored ZED1 nucleotide and cation binding activity and showed that ZED1 is a catalytically dead pseudokinase, functioning solely as an allosteric regulator upon effector recognition. We used our library of ZED1 point mutants to identify the ZED1 activation loop regions as the most likely cause of interspecies ZAR1-ZED1 incompatibility. Finally, we identified a mutation that abolished ZAR1-ZED1 interspecies incompatibility while retaining the ability to mediate HopZ1a recognition, which enabled recognition of HopZ1a through tomato (Solanum lycopersicum) ZAR1. This provides an example of expanded effector recognition through a ZAR1 ortholog from a non-model species.
Who Can Tell Which Banks Will Fail?
Authors: Blickle Kristian , Brunnermeier Markus , Luck Stephan 
Published: May 2024

Abstract
We study the run on the German banking system in 1931 to understand whether depositors anticipate which banks will fail in a major financial crisis. We find that deposits decline by around 20% during the run. There is an equal outflow of retail and nonfinancial wholesale deposits from both failing and surviving banks. In contrast, we find that interbank deposits almost exclusively decline for failing banks. Our evidence suggests that banks are better informed about which fellow banks will fail. In turn, banks being informed allows the interbank market to continue providing liquidity even during times of severe financial distress.
Potential impact of European Medicines Agency measures to minimize risk of serious side effects on JAKi prescribing and utilization in the UK
Authors: Tian Zixing , Kearsley-Fleet Lianne , Galloway James , Watson Kath ,   BSRBR-RA Contributors Group, Lunt Mark , Hyrich Kimme L 
Published: May 2024

Abstract

Objective
Janus kinase inhibitors (JAKis) or targeted synthetic (ts) disease-modifying antirheumatic drugs (DMARDs) effectively treat rheumatoid arthritis (RA). However, due to safety concerns, the European Medicines Agency (EMA) published risk-minimization measures limiting JAKi prescription to certain at-risk patients unless no suitable alternative is available. This analysis included patients who had started their first-ever JAKi (before EMA measures were published) in a large national cohort study to investigate the potential impact of these measures on JAKi prescribing and utilization in the UK.

Method
RA patients starting first-ever JAKi therapy in BSRBR-RA between 13 February 2017 and 31 May 2022 were included. The percentages of patients meeting the EMA risk criteria were presented. For the at-risk patients, their previous numbers of distinct biologic (b) DMARD classes prescribed were described.

Result
A total of 1341 patients were included, and 80% (N = 1075) met ≥1 EMA risk criterion. Of those who met ≥1 risk criterion, 529 patients (49%) had received JAKi as their first or second b/tsDMARD class, whereas 299 (28%) had received ≥3 prior bDMARD classes.

Conclusion
Four-fifths of RA patients who had commenced a JAKi before the EMA advisory were considered ‘at-risk’, with prescribing only advised if there was no suitable alternative. Almost a third of those patients had already received ≥3 bDMARDs classes, and alternative therapies would be very limited for them; however, suitable alternatives might have existed for the remaining proportion, especially for those who received a JAKi as their first or second b/tsDMARD, and re-evaluation of the suitability of their treatment may be needed.
Legal Basis for the Application of the Principles of Legality and Justice in the System of Administrative Proceedings of the Republic of Kazakhstan
Authors: Abdrasulov Ermek , Akhmetov Yerik , Abdrasulova Aizhan , Tapakova Vilor , Mutalyapova Aiman 
Published: May 2024

Abstract
The purpose of the work is to study the principles of legality and justice in the practice of administrative proceedings of the Republic of Kazakhstan. For this, methods such as system and comparative analysis, logical analysis, deduction, induction, and formal-legal methods were used. During the implementation of the study, the significance, and role of legal principles in administrative justice in the Republic of Kazakhstan were investigated. After analysing the model of the transition of the countries of the former USSR to the system of administrative justice and the specifics of its implementation in Kazakhstan, it was concluded that the principles of legality and justice are legally fixed in the Administrative Procedure Code of the Republic of Kazakhstan. This article analyses the studies of both Kazakhstani and foreign scientists concerning the application of laws and principles in administrative proceedings. In addition, some aspects of improving the system of administrative justice in the context of legislative regulation of the application of legal principles are considered. The practical value of the results obtained is to provide recommendations that will have an impact on the activities of the administrative justice system of Kazakhstan and will allow it to be implemented more efficiently.
Effects of Trace Mineral Injections on Measures of Growth and Trace Mineral Status of Primiparous Cows and their Calves
Authors: Hernandez Gracia P , Ferreira Matheus F L , Santos Aline C R , Bohnert David , Ranches Juliana 
Published: May 2024

Abstract
The objective of this study was to evaluate the effects of injectable trace minerals (ITM) administrations at strategic moments in the beef cattle production cycle. At calving, 50 primiparous cows (Angus × Hereford) and their calves were randomly assigned to 1 of 2 treatments: 1) ITM: cattle assigned to the ITM treatment received an ITM injection at calving and a subsequent administration at breeding (cattle over 2 yr: 1.0 mL/90 kg body weight [BW]; calves: 1.0 mL/45 kg BW); or 2) Control: cattle assigned to the control treatment were administered with saline following the same procedure as the cattle assigned to the ITM treatment. Body weight, blood, and liver samples were collected from dams and calves at multiple time points to evaluate the growth and mineral status of cow–calf pairs. All variables were analyzed using the MIXED procedure of SAS. A treatment effect (P = 0.02) was observed for Cu liver concentration of primiparous cows at breeding. Cows assigned to ITM treatment had greater Cu status than cohorts assigned to Control treatment. No treatment effects were observed for the mineral status or growth of calves. The administration of ITM to primiparous cows enhanced Cu status when grazing Cu forages scarce of Cu.