bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does involvement in food preparation track from adolescence to young adulthood and is it associated with better dietary quality? Findings from a 10-year longitudinal study
Authors: Laska Melissa N , Larson Nicole I , Neumark-Sztainer Dianne , Story Mary 
Published: November 2011

AbstractObjectivesTo examine whether involvement in food preparation tracks over time, between adolescence (15–18 years), emerging adulthood (19–23 years) and the mid-to-late twenties (24–28 years), as well as 10-year longitudinal associations between home food preparation, dietary quality and meal patterning.DesignPopulation-based, longitudinal cohort study.SettingParticipants were originally sampled from Minnesota public secondary schools (USA).SubjectsParticipants enrolled in Project EAT (Eating Among Teens and Young Adults)-I, EAT-II and EAT-III (n 1321).ResultsMost participants in their mid-to-late twenties reported an enjoyment of cooking (73 % of males, 80 % of females); however, few prepared meals including vegetables most days of the week (24 % of males, 41 % of females). Participants in their mid-to-late twenties who enjoyed cooking were more likely to have engaged in food preparation as adolescents and emerging adults (P < 0·01); those who frequently prepared meals including vegetables were more likely to have engaged in food preparation as emerging adults (P < 0·001), but not as adolescents. Emerging adult food preparation predicted better dietary quality five years later in the mid-to-late twenties, including higher intakes of fruit, vegetables and dark green/orange vegetables, and less sugar-sweetened beverage and fast-food consumption. Associations between adolescent food preparation and later dietary quality yielded few significant results.ConclusionsFood preparation behaviours appeared to track over time and engagement in food preparation during emerging adulthood, but not adolescence, was associated with healthier dietary intake during the mid-to-late twenties. Intervention studies are needed to understand whether promoting healthy food preparation results in improvements in eating patterns during the transition to adulthood.
Impact of technological synchronicity on prospects for CETI
Authors: Horvat Marko , Nakić Anamari , Otočan Ivana 
Published: November 2011

AbstractFor over 50 years, astronomers have searched the skies for evidence of electromagnetic signals from extraterrestrial (ET) civilizations that have reached or surpassed our level of technological development. Although often overlooked or given as granted, the parallel use of an equivalent communication technology is a necessary prerequisite for establishing contact in both leakage and deliberate messaging strategies. Civilization advancements, especially accelerating change and exponential growth, lessen the perspective for a simultaneous technological status of civilizations thus putting hard constraints on the likelihood of a dialogue. In this paper, we consider the mathematical probability of technological synchronicity of our own and a number of other hypothetical ET civilizations and explore the most likely scenarios for their concurrency. If Search for Extraterrestrial Intelligence (SETI) projects rely on a fortuitous detection of leaked interstellar signals (so-called ‘eavesdropping’) then with minimum prior assumptions N⩾138–4991 Earth-like civilizations have to exist at this moment in the Galaxy for the technological usage synchronicity probability p⩾0.95 in the next 20 years. We also show that since the emergence of complex life, coherent with the hypothesis of the Galactic habitable zone (GHZ), N⩾1497 ET civilizations had to be created in the Galaxy in order to achieve the same estimated probability in the technological possession synchronicity that corresponds to the deliberate signalling scenario.
Sound and Writing: Complementary Facets of the Anglo-Scottish Ballad
Authors: ATKINSON DAVID 
Published: November 2011

AbstractThe Anglo-Scottish ‘traditional’ ballad has coexisted in the different media of sound and writing from the early modern period to the present day. Nevertheless, it became the orthodoxy in the twentieth century that the ballad should be conceptually tied to its vocal performance. This essay seeks to argue that in fact a hierarchy of documentation that privileges sound is misleading. Rather, the ballad has always been, and remains, accessible through complementary media, fulfilling different purposes and following different conventions.It considers different levels of music-writing (‘prescriptive’ and ‘descriptive’) and the non-indexical relationship between sound and writing in the ontology of music. It goes on to relate the privileging of sound over writing to the ‘metaphysics of presence’, and offers theoretical reasons as to why both sound and writing can in fact be divorced from the metaphysics of presence. A further analogy is offered with the work of the text and music editor in establishing a ‘set of instructions’ for the reconstruction of the ‘work’. Some pragmatic examples and theoretical principles are considered in relation to how ballad words might be transcribed, leading to the conclusion that different and complementary sets of instructions facilitate access to the intangible ballad, without the need to posit any hierarchical relationship between sound and writing.
Involvement of α2‐ and β2‐adrenoceptors on breast cancer cell proliferation and tumour growth regulation
Authors: Pérez Piñero C , Bruzzone A , Sarappa MG , Castillo LF , Lüthy IA 
Published: November 2011

BACKGROUND AND PURPOSE β‐Adrenoceptors are expressed in human and experimental animal breast cancer cells. However, the effect of the agonists and antagonists reported on cell proliferation and tumour growth was paradoxical, precluding their utilization as possible adjuvant therapy, mainly in the cases of refractory tumours.EXPERIMENTAL APPROACH β‐Adrenoceptor expression was analysed by immunofluorescence and RT‐PCR. Cell proliferation was assessed by [3H]‐thymidine incorporation, tumour growth by measuring with a calliper and ERK 1/2 phosphorylation by Western blotting.KEY RESULTS β2‐Adrenoceptor expression was confirmed in the mouse and human cells tested. Cell proliferation was increased by adrenaline (by α2‐adrenoceptor action) and decreased in every tested cell line by the β‐adrenoceptor agonist isoprenaline and the β2‐adrenoceptor agonist salbutamol. Isoprenaline and salbutamol reduced tumour growth in every tumour tested (mouse C4‐HD and CC4‐3‐HI and human IBH‐4, IBH‐6 and MDA‐MB‐231 cell lines growing as xenografts in nude mice). These effects were reversed by the β‐adrenoceptor antagonist propranolol. The α2‐adrenoceptor antagonist rauwolscine and the β2‐adrenoceptor agonist salbutamol were equally effective in diminishing tumour growth. ERK 1/2 activation analysed in IBH‐4 tumours correlated with tumour growth, with the β‐adrenoceptor agonists decreasing its activation. Inhibition of ERK 1/2 phosphorylation in vitro was mainly mediated by the PKA pathway.CONCLUSIONS AND IMPLICATIONS In our experimental models, the β‐adrenoceptor agonists inhibited breast cancer cell proliferation and tumour growth, probably mediated by inhibition of ERK 1/2 phosphorylation. The β‐adrenoceptor agonists were as effective as the α2‐adrenoceptor antagonist rauwolscine, providing possible novel adjuvant treatments for breast cancer.
Correlations among Lower Urinary Tract Symptoms, Bother, and Quality of Life in Patients with Benign Prostatic Hyperplasia and Associated Fluctuations with Tamsulosin Administration
Authors: GOTOH Momokazu , MATSUKAWA Yoshihisa , FUNAHASHI Yasuhito , KATO Masashi , MASEKI Yoshiro , NARITA Harunori , KAMIHIRA Osamu , HATTORI Ryohei 
Published: November 2011

Objectives: To estimate correlations among lower urinary tract symptoms (LUTS), bother, and quality of life (QOL) and assess fluctuations in these parameters after α1‐blocker administration in patients with benign prostatic hyperplasia (BPH).Methods: Untreated BPH patients with international prostate symptom scores (IPSS) ≥ 8 and IPSS‐QOL scores ≥ 2 were administered tamsulosin at 0.2 mg/day for 4 weeks in a prospective multicenter study. We subsequently estimated the IPSS, bother score for each IPSS item, BPH impact index (BII), and IPSS‐QOL score before and 4 weeks after tamsulosin administration. We also analyzed the LUTS that might strongly influence QOL by using a path analysis model.Results: Analyzable data were obtained from 198 of the 257 patients enrolled. The IPSS were highest for LUTS such as slow stream, followed by increased daytime frequency and nocturia. The bother score was highest for slow stream, followed by nocturia. We observed dissociations between IPSS and bother scores for both urgency and nocturia. After tamsulosin administration, total and individual IPSS, total and individual bother scores, total and individual BII scores, and IPSS‐QOL score demonstrated significant improvements. Path analysis showed that physical discomfort and bothersomeness were BII items that strongly influenced QOL. Furthermore, feeling of incomplete emptying, urgency, and slow stream were LUTS that strongly influenced QOL.Conclusion: Tamsulosin administration improved patient QOL by possible mechanisms via improvement in subjective symptoms and bother. The LUTS that strongly influenced QOL comprised feeling of incomplete emptying, urgency, and slow stream.
Tradition as Impulse for Renewal and Witness: Introducing Orthodox Missiology in the IRM
Authors: Papathanasiou Athanasios N. 
Published: November 2011

AbstractAt the dawn of the 20th century the Orthodox churches found themselves in a strange, even contradictory situation. On the one hand, they had a rich missionary past (the Byzantine and the Russian missions) and a dynamic theology which accepted local cultures and stressed the importance of trinitarianism and pneumatology. Yet on the other hand, the Orthodox churches had turned inwards, locked in with the national identities of the traditionally Orthodox countries. Thus Orthodox theology was almost completely absent during the first two decades of the International Review of Missions. Then some Orthodox voices began to appear. The most important Orthodox contributions to the IRM have been the holistic understanding of mission as martyria and diakonia, an inclusive approach to Christ's cosmic work, and the understanding of the church as the foretaste of the kingdom and the servant of the missionary God.
An Organoselenium Compound Inhibits Staphylococcus aureus Biofilms on Hemodialysis Catheters
In Vivo
Authors: Tran Phat L. , Lowry Nathan , Campbell Thomas , Reid Ted W. , Webster Daniel R. , Tobin Eric , Aslani Arash , Mosley Thomas , Dertien Janet , Colmer-Hamood Jane A. , Hamood Abdul N. 
Published: November 2011

ABSTRACT

Colonization of central venous catheters (CVCs) by pathogenic bacteria leads to catheter-related bloodstream infections (CRBSIs). These colonizing bacteria form highly antibiotic-resistant biofilms.
Staphylococcus aureus
is one of the most frequently isolated pathogens in CRBSIs. Impregnating CVC surfaces with antimicrobial agents has various degrees of effectiveness in reducing the incidence of CRBSIs. We recently showed that organoselenium covalently attached to disks as an antibiofilm agent inhibited the development of
S. aureus
biofilms. In this study, we investigated the ability of an organoselenium coating on hemodialysis catheters (HDCs) to inhibit
S. aureus
biofilms
in vitro
and
in vivo
.
S. aureus
failed to develop biofilms on HDCs coated with selenocyanatodiacetic acid (SCAA) in either static or flowthrough continuous-culture systems. The SCAA coating also inhibited the development of
S. aureus
biofilms on HDCs
in vivo
for 3 days. The SCAA coating was stable and nontoxic to cell culture or animals. This new method for coating the internal and external surfaces of HDCs with SCAA has the potential to prevent catheter-related infections due to
S. aureus
.
Fracture characterization in the Chalk and the evolution of the Thanet monocline, Kent, southern England
Authors: Ameen Mohammed S. 
Published: November 2011

Abstract

Systematic studies of fractures in the exposed Upper Cretaceous Chalk and from seismic data are used to establish the evolution of the regional structure and the related fractures on the Isle of Thanet, Kent. The results show that the main structure developed as an easterly trending, south facing, monoclinal forced fold with a WNW-ESE trending cross forced fold along a basement grain (Pegwell Bay-Minnis Bay transtension/transpression zone). The folding started during the deposition of the Chalk in the Upper Cretaceous due to an extensional tectonic phase accompanied by differential sedimentation and compaction [vertical (
σ
1
) and horizontal (
σ
3
)] which induced vertical and steep macrofractures (mainly joints and some extensional faults) in the Chalk. This was followed late in the Upper Cretaceous by a horizontal, N-S compression (
σ
1
) which continued in the Tertiary and caused inversion of movement on the basement faults and the occurrence of the final stages in the forced folding. The latter phase led to the rejuvenation of the pre-existing fractures in the cover (mainly by faulting) and the development of new fractures (mostly faults and joints). An uplifting/unloading phase started late in the deformation history and caused the occurrence of near horizontal (bedding-parallel) fractures (joints) and bedding-perpendicular or steep mesofractures parallel to, and perpendicular to, the burial/tectonic macrofractures. These have particularly developed at the top several metres of the exposed Chalk where a rapid increase in frequency of fractures is clear.

The fracture characterization of the Chalk varies significantly in different parts of the monocline. Based on such variation a minimum of four domains (zones) have been identified. The heterogeneity in the fracture development is most probably controlled by the variation in orientation and type of the causative basement faults and the amount and type of displacement on them.
Single view reflectance capture using multiplexed scattering and time-of-flight imaging
Authors: Naik Nikhil , Zhao Shuang , Velten Andreas , Raskar Ramesh , Bala Kavita 
Published: November 2011

This paper introduces the concept of time-of-flight reflectance estimation, and demonstrates a new technique that allows a camera to rapidly acquire reflectance properties of objects from a single view-point, over relatively long distances and without encircling equipment. We measure material properties by indirectly illuminating an object by a laser source, and observing its reflected light indirectly using a time-of-flight camera. The configuration collectively acquires dense angular, but low spatial sampling, within a limited solid angle range - all from a single viewpoint. Our ultra-fast imaging approach captures space-time "streak images" that can separate out different bounces of light based on path length. Entanglements arise in the streak images mixing signals from multiple paths if they have the same total path length. We show how reflectances can be recovered by solving for a linear system of equations and assuming parametric material models; fitting to lower dimensional reflectance models enables us to disentangle measurements.
We demonstrate proof-of-concept results of parametric reflectance models for homogeneous and discretized heterogeneous patches, both using simulation and experimental hardware. As compared to lengthy or highly calibrated BRDF acquisition techniques, we demonstrate a device that can rapidly, on the order of seconds, capture meaningful reflectance information. We expect hardware advances to improve the portability and speed of this device.
Semantic annotation of biological concepts interplaying microbial cellular responses
Authors: Carreira Rafael , Carneiro Sónia , Pereira Rui , Rocha Miguel , Rocha Isabel , Ferreira Eugénio C , Lourenço Anália 
Published: November 2011

Abstract

Background
Automated extraction systems have become a time saving necessity in Systems Biology. Considerable human effort is needed to model, analyse and simulate biological networks. Thus, one of the challenges posed to Biomedical Text Mining tools is that of learning to recognise a wide variety of biological concepts with different functional roles to assist in these processes.

Results
Here, we present a novel corpus concerning the integrated cellular responses to nutrient starvation in the model-organism Escherichia coli. Our corpus is a unique resource in that it annotates biomedical concepts that play a functional role in expression, regulation and metabolism. Namely, it includes annotations for genetic information carriers (genes and DNA, RNA molecules), proteins (transcription factors, enzymes and transporters), small metabolites, physiological states and laboratory techniques. The corpus consists of 130 full-text papers with a total of 59043 annotations for 3649 different biomedical concepts; the two dominant classes are genes (highest number of unique concepts) and compounds (most frequently annotated concepts), whereas other important cellular concepts such as proteins account for no more than 10% of the annotated concepts.

Conclusions
To the best of our knowledge, a corpus that details such a wide range of biological concepts has never been presented to the text mining community. The inter-annotator agreement statistics provide evidence of the importance of a consolidated background when dealing with such complex descriptions, the ambiguities naturally arising from the terminology and their impact for modelling purposes.
Availability is granted for the full-text corpora of 130 freely accessible documents, the annotation scheme and the annotation guidelines. Also, we include a corpus of 340 abstracts.
Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
Authors: Lo Bernice , Swafford Austin DE , Shafer-Weaver Kimberly A , Jerome Lawrence F , Rakhlin Luba , Mathern Douglas R , Callahan Conor A , Jiang Ping , Davison Lucy J , Stevens Helen E , Lucas Carrie L , White Jill , von Borstel Reid , Todd John A , Lenardo Michael J 
Published: November 2011

AbstractBackgroundThe detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard125I-insulin radiobinding assay (RBA) has low reproducibility between laboratories, long sample processing times and requires the use of newly synthesized radiolabeled insulin for each set of assays. Therefore, a rapid, non-radioactive, and reproducible assay is highly desirable.MethodsWe have developed electrochemiluminescence (ECL)-based assays that fulfill these criteria in the measurement of IAA and anti-insulin antibodies (IA) in non-obese diabetic (NOD) mice and in type 1 diabetic individuals, respectively. Using the murine IAA ECL assay, we examined the correlation between IAA, histopathological insulitis, and blood glucose in a cohort of female NOD mice from 4 up to 36 weeks of age. We developed a human IA ECL assay that we compared to conventional RBA and validated using samples from 34 diabetic and 59 non-diabetic individuals in three independent laboratories.ResultsOur ECL assays were rapid and sensitive with a broad dynamic range and low background. In the NOD mouse model, IAA levels measured by ECL were positively correlated with insulitis severity, and the values measured at 8-10 weeks of age were predictive of diabetes onset. Using human serum and plasma samples, our IA ECL assay yielded reproducible and accurate results with an average sensitivity of 84% at 95% specificity with no statistically significant difference between laboratories.ConclusionsThese novel, non-radioactive ECL-based assays should facilitate reliable and fast detection of antibodies to insulin and its precursors sera and plasma in a standardized manner between laboratories in both research and clinical settings. Our next step is to evaluate the human IA assay in the detection of IAA in prediabetic subjects or those at risk of type 1 diabetes and to develop similar assays for other autoantibodies that together are predictive for the diagnosis of this common disorder, in order to improve prediction and facilitate future therapeutic trials.
The Dipeptide Phe-Phe Amide Attenuates Signs of Hyperalgesia, Allodynia and Nociception in Diabetic Mice Using a Mechanism Involving the Sigma Receptor System
Authors: Ohsawa Masahiro , Carlsson Anna , Asato Megumi , Koizumi Takayuki , Nakanishi Yuki , Fransson Rebecca , Sandström Anja , Hallberg Mathias , Nyberg Fred , Kamei Junzo 
Published: November 2011

Background: Previous studies have demonstrated that intrathecal administration of the substance P amino-terminal metabolite substance P1-7 (SP1-7) and its C-terminal amidated congener induced antihyperalgesic effects in diabetic mice. In this study, we studied a small synthetic dipeptide related to SP1-7 and endomorphin-2, i.e. Phe-Phe amide, using the tail-flick test and von Frey filament test in diabetic and non-diabetic mice. Results: Intrathecal treatment with the dipeptide increased the tail-flick latency in both diabetic and non-diabetic mice. This effect of Phe-Phe amide was significantly greater in diabetic mice than non-diabetic mice. The Phe-Phe amide-induced antinociceptive effect in both diabetic and non-diabetic mice was reversed by the σ1 receptor agonist (+)-pentazocine. Moreover, Phe-Phe amide attenuated mechanical allodynia in diabetic mice, which was reversible by (+)-pentazocine. The expression of spinal σ1 receptor mRNA and protein did not differ between diabetic mice and non-diabetic mice. On the other hand, the expression of phosphorylated extracellular signal-regulated protein kinase 1 (ERK1) and ERK2 proteins was enhanced in diabetic mice. (+)-Pentazocine caused phosphorylation of ERK1 and ERK2 proteins in non-diabetic mice, but not in diabetic mice. Conclusions: These results suggest that the spinal σ1 receptor system might contribute to diabetic mechanical allodynia and thermal hyperalgesia, which could be potently attenuated by Phe-Phe amide.
Fractionation and characterization of lignin carbohydrate complexes (LCCs) of Eucalyptus globulus in residues left after MWL isolation. Part I: Analyses of hemicellulose-lignin fraction (HC-L)
Authors: Miyagawa Yasuyuki , Takemoto Ooki , Takano Toshiyuki , Kamitakahara Hiroshi , Nakatsubo Fumiaki 
Published: November 2011

Abstract
The residual wood meal left after milled wood lignin (MWL) isolation (MWR) was extracted with the cellulose solvent lithium chloride/N,N-dimethylacetamide (LiCl/DMAc) to obtain a soluble fraction (C-L) and an insoluble fraction (C-L-residue). The C-L-residue was further extracted with the hemicellulose solvent 3 M NaOH to give a soluble fraction named hemicellulose-lignin fraction (HC-L) with 21.3% yield based on MWR. It was found that HC-L was composed of xylan, cellulose and lignin with abundant S-type β-O-4 substructures. HC-L lignin was bonded to HC-L cellulose or HC-L hemicelluloses or both. The method, which comprised acetylation for hardwood xylan (by acetic anhydride/pyridine/formamide) and extraction with chloroform, was found to be effective for selective xylan acetate fractionation. HC-L was further fractionated by the same method and subsequent deacetylation to give a xylan-lignin fraction (X-L) in 11.3% yield based on HC-L. X-L was composed mainly of xylan and lignin with abundant S-type β-O-4 substructures, and bonded to X-L xylan. X-L is considered as a promising fraction for elucidation of the structure of lignin-carbohydrate linkages.