bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Polyacrylic Acid as a Universal Aqueous Binder for Ni‐Rich Cathodes NMC811 and Si Anodes in Full Cell Lithium‐ion Batteries
Authors: Boz Buket , Fröhlich Katja , Neidhart Lukas , Molaiyan Palanivel , Bertoni Giovanni , Ricci Marco , De Boni Francesco , Vuksanovic Miljana , Romio Martina , Whitmore Karin , Jahn Marcus 
Published: April 2024

AbstractSilicon (Si) and silicon/graphite (Si/Gr) composite anodes are promising candidates due to their high theoretical capacity, low operating potential and natural abundance for high energy density Li‐ion batteries. Green electrode production, eliminating organic volatile solvents require advancement of aqueous electrodes. Engineering the binder plays a critical role for improving waterborne electrodes. Lithium substituted polyacrylic acid LiPAA has been demonstrated as a promising binder for Si/Gr anodes and for Ni‐rich cathodes in different cell configurations. LiPAA is utilized to minimize the volume expansion during cycling for Si/Gr anodes. LiPAA is formed in situ during cathode slurry preparation to regulate the pH and dimmish the Li loss. Using advanced characterization techniques, we investigated the slurries, electrodes, and active material reaction with LiPAA and its effect to the cycling performance. Our results indicate that the performance of high Si containing anode is limited by the amount of Si in the electrode. The failure mechanism with respect to high Si content was studied thoroughly. Aqueous processed cathodes with LiPAA binder in combination with Si anodes outperformed NMP based cathodes. Hence, LiPAA was successfully utilized as an active binder for both a high Si containing anode and for a Ni rich cathode.
How PBPK Can Help to Understand Old Drugs and Inform their Dosing in Elderly: Amantadine Case Study
Authors: Shuklinova Olha , Neuhoff Sibylle , Polak Sebastian 
Published: April 2024

Amantadine, despite being on the market for 55 years, has several unknown aspects of its pharmacokinetics especially related to the influence of covariates such as age, disease, or interactions linked to amantadine's renal elimination. As amantadine is used in Parkinson's disease and is considered a potential candidate in COVID treatment and other diseases, there is an unmet need for thorough understanding of its pharmacokinetic in special populations, such as the elderly. We aimed to mechanistically describe amantadine pharmacokinetics in healthy subjects and shed some light on the differences in drug behavior between healthy volunteers (18–65 years) and an elderly/geriatric population (65–98 years) using PBPK modeling and simulation. The middle‐out PBPK model includes mechanistic description of drug renal elimination, specifically an organic cation transporter (OCT)2‐mediated electrogenic bidirectional transport (basolateral) and multidrug and toxic compound extrusion (MATE)1‐mediated efflux (apical). The model performance was verified against plasma and urine data reported after single and multiple dose administration in healthy volunteers and elderly patients from 18 independent studies. The ratios of predicted vs. observed maximal plasma concentration and area under the concentration–time curve values were within 1.25‐fold. The model illustrates that renal transporter activity is expected to decrease in healthy elderly compared to healthy volunteers, which is in line with literature proteomic data for OCT2. The model was applied to assess the potential of reaching toxicity‐related plasma concentrations in different age groups of geriatric subjects.
Approaches for Mapping and Analysis of R‐loops
Authors: Mukhopadhyay Pramiti , Miller Henry , Stoja Aiola , Bishop Alexander J. R. 
Published: April 2024

AbstractR‐loops are nucleic acid structures composed of a DNA:RNA hybrid with a displaced non‐template single‐stranded DNA. Current approaches to identify and map R‐loop formation across the genome employ either an antibody targeted against R‐loops (S9.6) or a catalytically inactivated form of RNase H1 (dRNH1), a nuclease that can bind and resolve DNA:RNA hybrids via RNA exonuclease activity. This overview article outlines several ways to map R‐loops using either methodology, explaining the differences and similarities among the approaches. Bioinformatic analysis of R‐loops involves several layers of quality control and processing before visualizing the data. This article provides resources and tools that can be used to accurately process R‐loop mapping data and explains the advantages and disadvantages of the resources as compared to one another. © 2024 Wiley Periodicals LLC.
Fine mapping and targeted genomic analyses of photoperiod‐sensitive gene (GB_PPD1) in Pima cotton (Gossypium barbadense L.)
Authors: Zhu Linglong , Gowda S. Anjan , Kuraparthy Vasu 
Published: April 2024

AbstractCotton grown in the United States are day‐length insensitive annuals and are grown under long‐day summers. Photoperiod sensitivity, present in tropical wild and landraces endemic to the center of origin and diversity, is a major barrier for the introgression of tropical gene pool into the US cotton. Previously, we mapped the major photoperiod response locus Gb_Ppd1 on chromosome D06 of Pima cotton (Gossypium barbadense L.). In the current study, an F2 population of 2112 gametes was used to fine map the Gb_Ppd1 locus. Two sequence‐tagged‐site and nine kompetitive allele‐specific polymerase chain reaction (KASP) markers were developed and the Gb_Ppd1 locus was fine mapped to 1.1 cM region flanked by novel markers 17‐KASP‐8, 17‐KASP‐10, and 15‐PR‐10A. The closely linked markers identified 2.10 Mb region in the G. barbadense genome that contained 18 putative gene sequences. A candidate gene Gbar_D06G014560 showed high homology to VASCULAR PLANT ONE ZINC FINGER PROTEIN 1 involved in photoperiodism in Arabidopsis. We evaluated the diagnostic polymorphisms for the flanking markers on a diversity panel of 91 Pima accessions. These markers would be useful in marker‐assisted selection of photoperiod response in cotton breeding. Further, quantitative gene expression analysis indicated that the CONSTANS (CO)/FLOWERING LOCUS T (FT) system is conserved in the photoperiod response pathway in Pima cotton, while CO and FT are likely not the causal genes underlying flowering time at the Gb_Ppd1 locus. The Gb_Ppd1 gene may be an upstream regulatory sequence in the FT gene pathway that controls photoperiodism in photoperiod‐sensitive cotton by affecting the CO/FT interaction under long‐day‐length conditions.
Perspective on Lignin Conversion Strategies That Enable Next Generation Biorefineries
Authors: Shrestha Shilva , Goswami Shubhasish , Banerjee Deepanwita , Garcia Valentina , Zhou Elizabeth , Olmsted Charles N. , Majumder Erica L.‐W. , Kumar Deepak , Awasthi Deepika , Mukhopadhyay Aindrila , Singer Steven W. , Gladden John M. , Simmons Blake A. , Choudhary Hemant 
Published: April 2024

AbstractThe valorization of lignin, a currently underutilized component of lignocellulosic biomass, has attracted attention to promote a stable and circular bioeconomy. Successful approaches including thermochemical, biological, and catalytic lignin depolymerization have been demonstrated, enabling opportunities for lignino‐refineries and lignocellulosic biorefineries. Although significant progress in lignin valorization has been made, this review describes unexplored opportunities in chemical and biological routes for lignin depolymerization and thereby contributes to economically and environmentally sustainable lignin‐utilizing biorefineries. This review also highlights the integration of chemical and biological lignin depolymerization and identifies research gaps while also recommending future directions for scaling processes to establish a lignino‐chemical industry.
Bursting oscillation characteristics and adaptive high‐order differential feedback controller of doubly fed induction generator system
Authors: Wang Kun , Chen Wei , Wei Zhanhong 
Published: April 2024

SummaryTo address the problem of bursting oscillations in doubly fed induction generator (DFIG) systems under external disturbances, an analysis method based on fast‐slow dynamics and a control strategy based on an adaptive high‐order differential feedback controller (AHODFC) is proposed. The fast‐slow dynamics analysis method was adopted to reveal the formation mechanism of bursting oscillations from the DFIG system owing to the multi‐timescale coupling effect of perturbation, that is, the oscillation is in the form of a bursting oscillation with alternating large‐amplitude oscillation and micro‐amplitude oscillation. A control strategy based on the AHODFC with a high‐order differentiator (HOD) was proposed to address the problem of bursting oscillations in the DFIG system. The control strategy of the AHODFC has smooth control‐rate characteristics, does not depend on the exact mathematical model of the controlled system, and has good applicability and robustness to various types of bursting oscillations caused by different disturbance amplitudes and system parameters. Our simulations verified the feasibility and effectiveness of the proposed method.
Uniplanar printed four‐port MIMO antenna with self‐coupling‐self‐decoupling mechanism
Authors: Swain Jyotiprakash , Mohanty Asutosh , Behera Subhrakanta , Bhowmik Wriddhi 
Published: April 2024

SummaryThe proposed research is primarily investigated with a new methodology of utilizing parasitic constrictors (PCs) as self‐coupling‐self‐decoupling (SCSD) mechanism which has been strategically implemented in multiple‐input multiple‐output (MIMO) antenna design. The design asserts an uniplanar printed four‐port MIMO antenna configuration in a confined footprint of 0.6

0.6

0.015
(
= lowest operating wavelength at 2.9 GHz), where the radiator and reflector act as an effective SCSD invoking spatial diversity. The orthogonally oriented radiators are composed of 4
circular disc with a 45° tilt and cutaway for reducing near‐field condensed currents and improve 10‐dB impedance matching. The antennas are assisted with a uniquely designed coplanar wave guides as SCSD, with rotationally symmetric PC. The PC has coplanar slots and a thin metallic strip that connects to a center‐fed annular disc as intrinsic current neturalizer. A pair of inverted L‐shaped symmetric strips is introduced in the coplanar slots to effectively couple the near‐field currents for self‐induced resonance mechanism as well as self‐decoupled for isolation improvement. To validate the rational counterparts, a prototype antenna has been simulated, fabricated, and experimented to operate from (2.9–5.45) GHz. The potential outcomes show good convergence in simulated and experimental results, with effective 10‐dB IBW, isolation, and diversity parameters, and demonstrate its prospective in C‐band (5G) applications.
Potential impacts of climate change on the geographic distribution of Achillea eriophora DC., a medicinal species endemic to Iran in southwestern Asia
Authors: Noedoost Fariba , Behroozian Maryam , Karami Sahar , Joharchi Mohammad Reza 
Published: April 2024

AbstractClimate change is considered to rank among the most important global issues affecting species' geographic distributions and biodiversity. Understanding effects of climate change on species can enhance conservation efficacy. In this study, we applied ecological niche modeling (ENM) using maximum entropy (MaxEnt) approaches to predict the potential geographic distribution of Achillea eriophora DC., a medicinal plant species to Iran in southwestern Asia, under current and future climate scenarios. We evaluated potential distributional areas of the species, under two shared socioeconomic pathways (SSP2‐4.5 and SSP5‐8.5) for the period 2041–2060. Most current potential suitable areas were identified for A. eriophora in montane regions. Our results anticipated that the potential distribution of A. eriophora will expand geographically toward higher elevations and northward. However, the species is expected to experience relatively high losses of suitability in its actual habitats under future climate scenarios. Consequently, we recommend regional‐to‐national conservation action plans for A. eriophora in its natural habitats.
Phylogeography and population structure of Lagocephalus spadiceus (Richardson, 1845) (Tetraodontiformes, Tetraodontidae) in the South China Sea
Authors: Xu Hao , Huang Liangliang , Chen Tao , Wang Caiguang , Wu Zhiqiang , Cheng Yanan , Su Qiongyuan , Kang Bin , Yan Yunrong , Zhang Xiuguo 
Published: April 2024

AbstractThe climate fluctuations during the Late Pleistocene significantly influenced the phylogeographic structure and historical dynamics of marine fishes in the marginal seas of the western Pacific Ocean. The puffer fish, Lagocephalus spadiceus, holds substantial nutritional and economic value in the South China Sea. To investigate the demographic history and population structure of the L. spadiceus, the mitochondrial DNA COI and Cyt b gene datasets from 300 individuals across eight populations in the South China Sea were sequenced. Our findings revealed high haplotype diversity (0.874 ± 0.013) and low nucleotide diversity (0.00075 ± 0.00058). The phylogenetic tree and haplotype networks revealed no significant genetic differentiation along the northern coast of South China Sea. Neutrality tests, mismatch distribution analyses, and Bayesian skyline plots suggested that L. spadiceus underwent population expansion during the Late Pleistocene. Both ocean currents and climate change significantly influenced the geographical distribution and genetic population structure of L. spadiceus.
Nickel‐Catalysed syn‐Selective Arylnickelation and Cyclisation of Ketone/Imine‐Tethered Terminal Alkynes with Arylboronic Acids
Authors: Morgan Dáiríne M. , Lam Hon Wai , Guiry Patrick J. 
Published: April 2024

AbstractHerein we report a syn‐arylnickelative cyclisation with ketone‐ and imine‐tethered terminal alkynes (16 examples) in yields of up to 89 %. The reaction proceeds via a syn‐aryl nickelation of a terminal alkyne followed by cyclisation of the resulting alkenylnickel species onto the ketone or imine. The enantioselective version of this transformation has also been explored with enantioselectivities of up to 83 : 17 er observed.
Advances in triboelectric nanogenerators for self‐powered wearable respiratory monitoring
Authors: Kwak William , Yin Junyi , Wang Shaolei , Chen Jun 
Published: April 2024

AbstractTriboelectric nanogenerators (TENGs) have recently gained attention as a compelling platform technology for building wearable bioelectronics. Aside from being self‐powered, TENGs are lightweight, low in cost, rich in material choice, comfortable to wear, and increasingly versatile with advances in sensitivity and efficiency. Due to these features, TENGs have become appealing in biomedical sensing applications, especially for human respiration monitoring. A wealth of information can be collected by breath‐induced electrical signals, which are crucial in the analysis of a patient's respiratory condition and the early detection of harmful respiratory‐linked diseases. TENGs have thus been used to continuously collect important respiratory data, from the breathing patterns, flow rate, and intensity of an individual's respiratory cycle to the chemicals that may be present in their breath. This review paper provides an overview of recent developments in TENG‐based wearable respiratory monitoring as well as future opportunities and challenges for respiratory healthcare.
3D printing of hydrogels for flexible micro‐supercapacitors
Authors: Baig Mutawara Mahmood , Khan Suhail Ayoub , Ahmad Hamza , Liang Jin , Zhu Guoyin , Pang Huan , Zhang Yizhou 
Published: April 2024

AbstractAdvances in hydrogel technology have paved the way for novel and valuable capabilities that are being applied to a diverse spectrum of energy storage applications. Hydrogels, originally renowned for their biomedical applications, are now finding translation into the energy storage domain. These versatile materials exhibit promising potential for various energy‐related applications, including but not limited to acting as highly flexible electrolytes, facilitating the development of flexible supercapacitors, and contributing to advancements in energy conversion devices. The tunable properties of hydrogels, their high ion accessibility, and desirable mechanical characteristics position them as promising candidates for enhancing the performance and efficiency of energy storage systems. In this review, we emphasize the integration of hydrogels into flexible micro‐supercapacitors through 3D printing technology, unraveling the charge transport mechanisms inherent in hydrogels. We discuss methods for developing hydrogels with enhanced physicochemical properties, such as improved mechanical strength, flexibility, and charge transport, offering new prospects for next‐generation energy storage devices. With a deeper understanding of gelation chemistry, we showcase significant progress in fabricating stimuli‐responsive, self‐healing, and highly stretchable hydrogels. Furthermore, we present compelling examples highlighting the versatility of hydrogels, including tailorable architectures, conductive nanostructures, 3D frameworks, and multifunctionalities. The application of innovative 3D printing techniques in hydrogel design is poised to yield materials with immense potential in the realm of energy storage.
Understanding and modulating the horizontal orientations and short‐range charge transfer excited states for high‐performance narrowband emitters
Authors: Du Mingxu , Chen Yang , Mai Minqiang , Fan Tianjiao , Jin Qian , Zhang Yuewei , Duan Lian 
Published: April 2024

AbstractRecently, a novel paradigm of boron‐ and nitrogen‐embedded polycyclic nanographites featuring multiple resonance thermally activated delayed fluorescence (MR‐TADF) has garnered substantial interest due to their extraordinary attributes of efficient narrowband emissions with small full width at half maxima (FWHMs). Despite an array of diverse color tuning strategies, it remains elusive how to effectively manipulate device efficiencies without altering the materials' intrinsic MR‐TADF characteristics. Here, an advanced ‘non‐conjugate fusion’ design methodology was proposed, aimed at dramatically amplifying the horizontal orientations of MR‐TADF emitters while preserving the short‐range charge‐transfer properties. As envisioned, when compared to the classical BCz‐BN mother core, the proof‐of‐concept emitter mICz‐BN achieved an impressively enhanced horizontal dipole ratio (83% vs. 75%) at analogous emission wavelengths (∼486 nm), FWHMs (∼26 nm) and photoluminescence quantum yields (∼93%). Consequently, the external quantum efficiency of the optimized device yielded a performance enhancement of 1.2‐fold (30.5% vs. 25.3%) whilst keeping the spectrum almost unchanged.
Effect on blood lipids and body composition of a high‐fat (MUFA) and high‐fiber diet: A case–control study
Authors: Romero‐Marco Patricia , Chicharro Celia , Verde Zoraida , Miguel‐Tobal Francisco , Fernández‐Araque Ana 
Published: April 2024

AbstractMetabolic Syndrome (MetS) is a constellation of risk factors including abdominal obesity, high triglycerides, low HDL cholesterol (HDL‐C), elevated blood pressure, and elevated fasting glucose. In Spain, according to WHO criteria, the MetS prevalence is shown to be 32% in men and 29% in women. The role of dietary habits is one of the main therapeutic strategies for the management of MetS but the most effective dietary pattern has not been established yet. This study aimed to analyze the effect of on body composition, serum lipids, and MetS components of a high‐MUFA and high‐fiber diet (HMFD). A case–control study was performed considering 40 cohabiting women. Participants were randomly assigned to HMFD group or high mono‐unsaturated diet (HMD) group to receive one of the two proposed dietary interventions. All data (serum lipids, blood pressure, height, weight, body composition, and waist circumference) were collected fasting at baseline, 55, 98, and 132 days. The HMFD group showed higher decrease in waist circumference than in the HMD group. LDL‐C dropped in both groups. Triglycerides in the HMFD group dropped during the intervention, but once the intervention was over, they returned to baseline values. The mean systolic blood pressure was lower in HMFD group. A HMFD from a weekly consumption of processed meat (Torrezno de Soria) deeply fried in extra virgin olive oil in combination with vegetables logged in a Mediterranean diet can improve MetS risk factors in healthy overweight women.
Costs of care trajectories of people with dementia compared with matched controls. Longitudinal analysis of linked health and administrative data
Authors: Bosmans Judith E. , van der Heide Iris , van Hout Hein P. J. , Joling Karlijn J. 
Published: April 2024

AbstractObjectivesTo provide insight into the health and social care costs during the disease trajectory in persons with dementia and the impact of institutionalization and death on healthcare costs compared with matched persons without dementia.MethodsElectronic health record data from family physicians were linked with national administrative databases to estimate costs of primary care, medication, secondary care, mental care, home care and institutional care for people with dementia and matched persons from the year before the recorded dementia diagnosis until death or a maximum of 4 years after the diagnosis.ResultsTotal mean health and social care costs among persons with dementia increased substantially during the disease trajectory, mainly due to institutional care costs. For people who remained living in the community, mean health and social care costs are higher for people with dementia than for those without dementia, while for those who are admitted to a long‐term care facility, mean health and social care costs are higher for people without dementia than for those with dementia.ConclusionsThe steep rise in health and social care costs across the dementia care trajectory is mainly due to increasing costs for institutional care. For those remaining in the community, home care costs and hospital care costs were the main cost drivers. Future research should adopt a societal perspective to investigate the influence of including social costs.
Unraveling the RNA Tapestry: A Symphony of Innovations in m6A Research Technology
Authors: Fei Shengyi , Fang Zheng William , Zhao Boxuan Simen 
Published: April 2024

AbstractThis review navigates the evolving landscape of N6‐methyladenosine (m6A) research approaches, emphasizing the importance of advanced technology in understanding RNA epigenetics. Beginning with the fundamentals of m6A and the need for high‐ throughput methods, the investigation progresses from low‐throughput approaches to high‐throughput technologies, encompassing antibody‐dependent and antibody‐free sequencing methods, as well as nanopore‐based direct mRNA sequencing and computation methods for m6A detection. Spatial techniques and imaging tools for m6A are also introduced in addition. The discussion of their special applications emphasizes the biological significance of absolute quantification, single‐nucleotide resolution, single‐molecule detection, and single‐cell profiling. The review concludes with a vision of ideal approaches that combine current technologies for comprehensive m6A sequencing, with the potential to further our understanding of gene regulation, cellular diversity, and their roles in health and disease.