bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Domain Mutations in FAT4 Cadherin 21-34 Predicts Improved Prognosis in Gastric Cancer Patients: A Retrospective Study
Authors: Wang Shu , Duan Weiming , Zhao Yan , Zhao Feilong , Ma Yuxuan , Wang Yuhao , Wang Haoyuan , Peng Chaosheng , Yang Jianjun 
Published: April 2024

Abstract

Background: Gastric cancer is characterized by high incidence and mortality rates. Survival improvement relies on the identification of novel prognostic factors and the implementation of stratified precision therapy. FAT4, a crucial tumor suppressor gene, has been shown to be mutated in various tumor types. However, our understanding of the association between FAT4 mutations and the prognosis of patients with gastric cancer is limited.
Methods: In this study, the impact of the FAT4 gene on prognosis was investigated using data from the TCGA database. NGS was performed on real-world gastric adenocarcinoma patients receiving different types of treatment. The conclusions from the public database were further validated. Multivariate Cox regression analysis was conducted to ascertain the prognostic significance of the FAT4 gene in the real-world cohort. Lollipop plots were generated to analyze the mutation sites in the FAT4 gene in the two cohorts, and survival disparities among distinct mutation sites were assessed using Kaplan‒Meier curves. Moreover, GSEA and immune infiltration analysis, based on the XCELL and CIBERSORT databases, were applied to explore the associations between different FAT4 mutation sites and immune infiltration.
Results: The mutational profile of FAT4 has been shown to be associated with increased survival and has been further validated by real-world next-generation sequencing (NGS) in patients with gastric adenocarcinoma. Specifically, mutations in the FAT4 cadherin 21-34 site were linked to even greater survival benefits than were mutations in cadherin 1-20 or wild-type FAT4. Patients with cadherin 21-34 mutations showed increased infiltration of immune cells, including CD4+ and CD8+ T cells, as well as M1 tumor-associated macrophages (TAMs), suggesting a potential connection between FAT4 mutations and enhanced immune infiltration.
Conclusions: This study highlights the importance of the FAT4 gene in predicting gastric cancer prognosis. Further research is needed to explore its comprehensive genetic landscape and impact on patient outcomes. These findings have implications for clinical practice, informing treatment decisions based on FAT4 gene mutations.
Trace mineral source influences trace mineral solubility in water and mineral binding strength to ruminal digesta
Authors: Loh Huey Yi , Spears Jerry W. , Guimaraes Octavio , Miller Alexandra C. , Thorndyke Meghan P. , Thomas Tyler A. , Engle Terry E. 
Published: April 2024

Abstract

Two experiments were conducted to examine the impact of trace mineral (TM) source on in vitro and in vivo solubility characteristics. Experiment 1: Hydroxy TM (HTM) and sulfate TM (STM) sources of Cu, Mn, and Zn were incubated separately in water for 24 h. Immediately after mixing, initial pH of each solution was greater (P < 0.03) for HTM compared to STM for all elements. Final pH tended to be greater for Cu (P = 0.09) and Zn (P = 0.07) from HTM compared to STM. Water solubility of Cu, Mn, and Zn from STM was greater (P < 0.01) than HTM sources. Experiment 2: Eight steers fitted with rumen cannula were blocked by body weight and randomly assigned to treatments. Treatments consisted of 10 mg Cu, 40 mg Mn, and 60 mg Zn/kg DM from either STM or HTM sources. Steers were individually fed a cracked corn-corn silage-based diet. Treatments were top-dressed daily. Rumen contents were collected at 0, 2, and 4 h post-feeding on d 1 and 14. On d 15, strained ruminal fluid and particle-associated microorganisms were obtained. Zinc was more tightly bound (P = 0.01) to the digesta in HTM-supplemented steers compared to STM on d 14. These data indicate that TM source influences pH and solubility of Cu, Mn, and Zn in water and may affect rumen soluble Cu concentrations and binding strength of Zn to solid digesta.
Perception, benefits and barriers to community pharmacy vaccination services in Nigeria; a cross-sectional study of two south-western states
Authors: Oseni Yejide Olukemi , Okafor Ukamaka Gladys , Odukoya Taofik Oladipupo , Oluyedun Hamidu Adediran , Ajibade Abiodun Abdulah , Azeez Yusuff Olanrewaju , Okonu Abigail Isaac , Adetunji Oladapo Adewale 
Published: April 2024

Abstract

Perception, benefits and barriers to community pharmacy vaccination services in Nigeria; a cross-sectional study of two south-western states
Background:
The pharmacy association in Nigeria is working assiduously to ensure that community pharmacists and pharmacies are included in national database as vaccinators and vaccination centres for routine immunisation but no study had assessed community pharmacists’ opinions on the expanded scope to their practice. This study assesses the perception of community pharmacists, perceived benefits and potential barriers to these services to determine their readiness.
Methods:
Semi-structured, self-administered questionnaire on a 5-point Likert scale was distributed to 474 selected community pharmacists through hard copies and Google forms in Year 2023, to assess their perception, perceived benefits and potential barriers to community pharmacy vaccination services. Data were analysed with descriptive and inferential statistics where p-value was set at <0.05.
Results:
Respondents agreed that community pharmacies should be involved in administration of vaccines (98.8%), their inclusion into the national data as vaccinator is a welcomed development (98.5%), and community pharmacists should be given the authority to administer vaccines (96.6%). Total mean score of 27.93 (SD +2.768) from a total score of 30 was obtained. Respondent further agreed and strongly agreed that this will improve vaccination coverage (99.5%), increase accessibility to vaccines (99.3%), improve the provision of pharmaceutical care service and rational use of medicines (98.5%), among others with total mean score of 51.12 (SD + 4.281) from a total score of 55. Lack of authorization by the government and existing policy not in support of the service was the highest potential barrier (85.6%) with total mean score of 39.96 (SD + 7.325) from a total score of 55. In overall, perceived benefits and perception are strongly and positively correlated (r=0.645, p<0.001) and there was a significant difference between the two (t410 =143.669, p<0.001).
Conclusion:
The study concluded that most of the respondents had positive perception about community pharmacies vaccination services and using community pharmacies and pharmacists as vaccination centres and vaccinators respectively will improve vaccination coverage. Despite potential barriers noted which could be overcome by the community pharmacists themselves, lack of government authorisation needs to be handled at policy making level.
Acceptability and effectiveness of stationary bike intervention on health outcomes among older adults: a systematic review of intervention studies
Authors: Akter Taiyeba , Moneruzzaman Md. , Maduray Kellina , Kader Manzur 
Published: April 2024

Abstract

Background: A systematic search was conducted across seven databases - PubMed, Web of Science, Scopus, Cochrane Library, SportDiscus, CINAHL, and PsychInfo - following PRISMA guidelines until June 18, 2023, with no year limitations. After excluding duplicates, studies were screened by two independent reviewers in a two-stage process. This review included all original intervention studies with baseline and post-intervention outcomes involving SB as a health assessment tool, and/or a part of an intervention method among people aged 60 years or over.
Methods: Using PRISMA guidelines, seven databases were searched until June 18, 2023, without year limitations. After removing duplicates, two reviewers independently screened studies in two stages. This review included original intervention studies with baseline and post-intervention outcomes involving SB as a health assessment tool or intervention method among individuals aged 60 years, or older.
Results: Out of 8,022 citations, 47 English-language articles were included: 28 Randomized Controlled Trials (RCTs) and 19 (40.43%) Non-RCTs, including Pretest-posttest and Quasi-Experimental studies. The most common focus points of the included studies were Cognitive function, Motor and Balance, Physiological and Psychological changes, Cardiovascular, and Executive function. The most common study populations had neurological problems (15/47, 31.91% studies). Among the 47 included studies, the highest participants' acceptance rate was 38% (18/47 studies), while the retention rate was 15% (07/47 studies), the adherence rate was 6% (3/47 studies), and the lowest dropout rate was 13% (06/47 studies). Significant health outcomes after SBI included aerobic capacity (VO2 max), cognition, executive function, cycling efficiency, quality of life (QOL), and mobility (Timed up and Go test), mentioned in at least 5 studies. Virtual reality (VR)-assisted SBI showed better improvement in executive function compared to non-VR groups.
Conclusion: This review reveals varying rates of acceptability, retention, adherence, and dropout in SBI, highlighting challenges in participant engagement. However, despite these challenges, SBI shows promise in enhancing physical activity among seniors, with potential benefits across various health domains. Particularly noteworthy is the effectiveness of VR-assisted SBI in improving executive function among older adults, suggesting promising avenues for intervention. These results stress the significance of incorporating SBI into health interventions for older adults.
Cyclic Behavior of Concrete-Filled Double Steel Tubular Column with New Reinforced Circular Cross-Section
Authors: Faramarzzadeh Vahid , Ferdousi Adel , Zandi Yousf 
Published: April 2024

Abstract

The concrete-filled double tubular steel column (CFDST) is a composite column that shows remarkable potential for the construction of tall buildings and bridge piers. When this type of column is exposed to external forces such as collisions with ships or cargo vehicles, explosions or fires, it loses strength. The outer steel tube of the column is affected, resulting in the loss of the concrete inclusion between the two layers of steel. As a consequence, a significant drop in column strength becomes evident. The aim of this study is to investigate the effects of cyclic loading on CFDST columns with a new reinforced circular cross-section, which have a constant number of stiffeners and stirrups over the entire column. Two specimens were subjected to constant axial compression and lateral cyclic loading to compare the behavior of a proposed reinforced cross-section (new reinforced cross-section) with that of a simple cross-section. The data from the test was used to validate a finite element analysis (FEA). Subsequently, the validated numerical models were used to evaluate the effects of various parameters, including the thickness of the pipes and the compressive strength of the concrete, on both cross-sections. In summary, the results show a significant improvement in the cyclic behavior of the column with a reinforced cross-section compared to a simple cross-section. The recommended reinforced cross-section thus prevents a sudden drop in column strength after the outer steel tube has been damaged.
Spotting A Phony Attack by Concealing the Deception of The Web
Authors: Rao M Venkateswara , Naik Anjaiah Harshitha , Vineetha Budida , Priya Chiliveru Vishnu 
Published: April 2024

Abstract

In the current digital environment, phishing assaults pose a serious risk since malevolent actors are always coming up with new strategies to trick people. Artificial intelligence and machine learning are examples of cutting-edge technology that can be used to identify fake URLs and evaluate web content in order to combat this. Sentiment analysis tools are useful for detecting fraudulent reviews and unethical behavior. Blockchain technology can be used to confirm the legitimacy of products and stop the sale of fake items. The fraud payment can be predicted using logistic regression and random forest. Smooth front-end and back-end system integration facilitates real-time monitoring and analysis, allowing for prompt detection and handling of fraudulent assaults within a single web page. We can more effectively identify and counteract false assaults by leveraging cutting-edge technology, blockchain, and sentiment analysis on the internet, eventually safeguarding users and promoting a safer digital ecosystem.
A case of paroxetine-induced lower gastrointestinal bleeding: A multifaceted approach to healing
Authors: Jasassi Bushra Hamed Al , Shuhoumi Mohammed Abdullah Al 
Published: April 2024

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are a mainstay treatment for panic disorder, however a potential link to lower gastrointestinal bleeding (LGIB), particularly with Paroxetine, is unknown. We present a rare case of LGIB possibly caused by Paroxetine in a 35-year-old female with panic disorder. LGIB resolved after SSRI cessation, implying a possible causative relationship. We conducted a thorough clinical evaluation, including medical history, medication review, and endoscopic investigations. The patient complained of hematochezia, dizziness, and shortness of breath, which coincided with the start of Paroxetine for panic disorder. A colonoscopy indicated non-specific colitis, while an upper GI endoscopy revealed no abnormalities. LGIB resolved within a week of discontinuing Paroxetine, with no recurrence during following follow-up. This example adds to the little evidence pointing to a possible link between Paroxetine and LGIB in panic disorder. More research is required to understand the underlying mechanisms and confirm causality. While initially mysterious, this case eventually revealed the complicated connection between mental health, medicine, and physical manifestations. It emphasized the significance of alertness in monitoring potential side effects, the efficacy of alternative therapies such as CBT, and the importance of patient awareness in managing complex medical problems.
Empowering local communities with strategies for monitoring and eliminating poverty in urban areas (Case study, District 9 of Tehran)
Authors: Isazade Esmail , Abdelkhair Farah Yasin Farah , Isazade Vahid , Alavi Seyyed Ali , Ray Samrat , Kaplan Gordana , Qasimi Abdul Baser 
Published: April 2024

Abstract

Usually, developing countries use the capacity of governments and municipalities to provide appropriate services to the population. This category will increase poverty in cities and urban areas. This article aims to empower local communities with strategies to monitor and eliminate poverty in the neighborhoods of District 9 of Tehran. In this paper, we used the four geographic models in ArcGIS 10.3 for the spatial analysis and assessment of poverty, which includes Getis-OrdGi* (G-i-star) statistics (hot and cold spots), Moran's spatial autocorrelation, Vikor model and SWOT. First, from the economic, sociocultural, and physical indicators, urban poverty was identified at the neighborhood level in District 9 of Tehran. A quantitative model (Vikor) was used to rank the indicators. Getis-OrdGi* (G-i-star) (hot and cold spots) was used to display and spatially analyze urban poverty at the locality level of District 9. In addition, using the QSPM model, internal and external strategies of urban areas were identified. Moran's spatial autocorrelation was used to correlate the indicators. After placing the target locations, the SWOT technique was used to present the strengths and weaknesses of the target locations. The results showed the highest correlation between sociocultural indicators and urban poverty is in the southern neighborhoods of District 9 of Tehran, which corresponds to South Mehrabad, Shamshiry, South Sarasiab, and part of the Imamzadeh Abdullah neighborhood. In addition, due to high population density, immigration, and low land prices, the impact of the socio-cultural index on urban poverty in the north of District 9 has increased with a confidence level of 99%. While the hot spots of the economic dimension of poverty are at the level of districts of District 9 of Tehran, the southern and southeastern districts due to unemployment, high rent, and low household income, economic poverty clusters have been formed in terms of spatial autocorrelation, Moran's Index is 0/026180 showed. However, in the spatial distribution of poverty in terms of the physical dimension at the level of neighborhoods in District 9 of Tehran, nearly 10% of the neighborhoods have the worst poverty level. Only the Shamshiry neighborhood has the lowest per capita commercial, sports, and health facilities among the neighborhoods. Regarding Moran's spatial autocorrelation pattern, Moran's index and Z-score in the Shamshiri neighborhood showed 0.007270 and 4/224861, respectively. In addition, people's and non-governmental organizations are essential and effective strategies for monitoring and eliminating poverty at the level of target neighborhoods.
Robustification of Structural Equation Modelling via Global Sensitivity Analysis
Authors: Lachi Alessio , Llach Josep , Perramon Jordi , Baccini Michela , Saltelli Andrea 
Published: April 2024

Abstract

We propose a method for enhancing the robustness of structural equation modelling, a mul- tivariate statistical analysis technique employed for analyzing causal relationships among different aspects of given phenomena. This enhancement is achieved through the integra- tion of global sensitivity analysis, which assesses how uncertainties in model output can be attributed to various sources of input uncertainty. The robustification process involves several key steps, including bootstrapping evidence, error propagation, and uncertainty quantification. This method introduces a novel approach termed “modelling of the mod- elling process”. To illustrate this approach, we apply it to a previously published test case where structural equation modelling is used to relate the impact of artificial intelligence adoption on employee engagement. By quantifying the uncertainty inherent in the infer- ence from our test case, this procedure generates a more robust and defensible inference. The performed procedure significantly enhances the robustness of the results derived from the test case.
Cross-Domain Knowledge Transfer without Retraining to Facilitating Seamless Knowledge Application in Large Language Models
Authors: Kim Jae Hoon , Kim Hye Rin 
Published: April 2024

Abstract

Cross-domain knowledge transfer in large language models (LLMs) presents significant challenges, particularly regarding the extensive resources required for retraining. This research introduces innovative embedding adaptation and context adjustment techniques that enable LLMs to efficiently transfer knowledge across diverse domains without the need for comprehensive retraining. Experimental results demonstrate improved model flexibility and reduced computational demands, highlighting the potential for rapid deployment and scalability. These findings suggest a sustainable approach to deploying adaptive AI across various sectors, significantly impacting future developments in artificial intelligence.
Study on Different Sources of Wastewater in the Korotoa River: Focus on Medical Wastewater.
Authors: Mahmud Sheikh Hayath 
Published: April 2024

Abstract

Wastewater originating from various sources has been gradually polluting the Korotoa River. Notably, medical wastewater contains hazardous chemicals, including harmful substances that may be used in treatment. In this study, it identifies the composition of waste present in medical wastewater, which is indiscriminately disposed of into the Korotoa River. Unfortunately, people who bathe or fish in the Korotoa River face serious health risks due to exposure to this contaminated water. Skin diseases are prevalent among those who come into contact with it. Additionally, several hospitals situated near the Korotoa River discharge chemical-laden wastewater directly into the river on a daily basis. To address this issue, it assesses the water quality of the Korotoa River and compare it against the standard values provided by the Bangladesh Environment Conservation Rules (BECR 1997). Different parameters such as PH, BOD, COD, DO, Turbidity, color, TS, TSS, TDS and Alkalinity are tested for the water sample collected from different hospitals effluent. All parameters exceed the standard value which is very much alarming. Furthermore, it proposes potential measures to mitigate pollution in the Korotoa River, which are detailed in this paper.
Air Pollution Exposure and Olfactory Health: A Systematic Review
Authors: Shehab Maryam , Xia Xi , Chan Ka Hung , Lam Kin Bong Hubert , Kalantzi Olga-Ioanna , Arvaniti Olga S. , Tekeli Hakan 
Published: April 2024

Abstract

Exposure to air pollution can affect the olfactory system, causing disorders such as anosmia (partial or total loss of smell) and hypogeusia (reduced ability to taste). The objective of this study is to systematically review air pollution exposure and associated olfactory health disorders. The systematic review included air pollutant types, types of exposure, testing methods, and study limitations. Specific keywords related to air pollution and olfactory and/or gustatory functions were employed to search electronic databases (PubMed, Google Scholar, MEDLINE, Highwire, ResearchGate, and the Cochrane Library) for studies and reviews on exposure to air pollution that assess and measure smell and taste and published up to the year 2021. Non-English studies, studies on animals, plants, and exposure to pollutants other than air pollutants were excluded. Out of 1,100 identified studies, only 52 studies met the selection criteria. Forty-nine studies were related to olfactory health (sense of smell) associated with air pollution exposure, and three studies were related to gustatory health (sense of taste). Most studies reviewed had a small sample size and were subject to substantial confounding, making it implausible to determine a significant association between air pollution exposure and olfactory health. The review shows the study limitations and gaps that should be considered in future research related to olfactory/gustatory health and air pollution. To our knowledge, this is the first systematic review of the olfactory health studies related to air pollution exposure.