bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete remission after first-line radio-chemotherapy as predictor of survival in extranodal NK/T cell lymphoma
Authors: Chauchet Adrien , Michallet Anne-Sophie , Berger Françoise , Bedgedjian Isabelle , Deconinck Eric , Sebban Catherine , Antal Daciana , Orfeuvre Hubert , Corront Bernadette , Petrella Tony , Hacini Maya , Bouteloup Marie , Salles Gilles , Coiffier Bertrand 
Published: June 2012

AbstractBackgroundExtranodal nasal-type NK/T-cell lymphoma is a rare and severe disease. Considering the rarity of this lymphoma in Europe, we conducted a multicentric retrospective study on nasal-type NK/T cell lymphoma to determine the optimal induction strategy and identify prognostic factors.MethodsThirty-six adult patients with nasal-type NK/T-cell lymphoma were recruited and assessed. In total, 80 % of patients were classified as having upper aerodigestive tract NK/T-cell lymphoma (UNKTL) and 20 % extra-upper aerodigestive tract NK/T-cell lymphoma (EUNKTL).ResultsFor advanced-stage disease, chemotherapy alone (CT) was the primary treatment (84 %vs.10 % for combined CT + radiation therapy (RT), respectively), while for early-stage disease, 50 % of patients received the combination of CT + RT and 50 % CT alone. Five-year overall survival (OS) and progression-free survival (PFS) rates were 39 % and 33 %. Complete remission (CR) rates were significantly higher when using CT + RT (90 %)versusCT alone (33 %) (p < 0.0001). For early-stage disease, CR rates were 37 % for CT aloneversus100 % for CT + RT. Quality of response was significantly associated with survival, with 5-year OS being 80 % for CR patientsversus0 % for progressive disease patients (p < 0.01).ConclusionEarly RT concomitantly or sequentially with CT led to improved patient outcomes, with quality of initial response being the most important prognosticator for 5-year OS.
The role of vitamin D in children with recurrent Tonsillopharyngitis
Authors: Yildiz Ismail , Unuvar Emin , Zeybek Umit , Toptas Bahar , Cacina Canan , Toprak Sadık , Kilic Ayse , Aydin Salih 
Published: June 2012

AbstractBackgroundThe exact etiology of recurrent tonsillopharyngitis in children is not clear. Recurrent tonsillitis in children has multifactorial etiology like most of the diseases in childhood. In this study, our aim was to determine the potential role of vitamin D in recurrent tonsillitis by measuring serum 25-OH vitamin D levels and determining the vitamin D receptor polymorphism among children with recurrent tonsillitis.MethodsEighty-four children with recurrent tonsillitis and seventy-one healthy children aging between 2 and 10 years were enrolled in this study. Serum 25-OH vitamin D level was measured with ELISA and vitamin D receptor gene polymorphism (Apa1, Taq 1, Fok1) was determined by PCR. Serum 25-OH vitamin D level below 50 nmol/L was accepted as deficiency. The vitamin D receptor gene polymorphism in each group was compared.ResultsThe mean age was 5.6 ± 2.4 and 6.1 ± 2.7 years in study and control group, respectively. The average serum 25-OH vitamin D level was 142.7 ± 68.1 nmol/L in study group and 192.3 ± 56.1 nmol/L in control group. There was significant difference between the groups (p < 0.01). In study group, 4.7% (n = 4) of children had serum 25 OH vitamin D levels below 50 nmol/L. None of the children in control group had serum 25-OH vitamin D level below 50 nmol/L. There was no significant differences in vitamin D receptor gene polymorphisms between groups.ConclusionSerum 25-OH vitamin D levels in recurrent tonsillitis group were lower than those in healthy children. But, there was no difference in the incidence of vitamin D receptor gene polymorphism between the two groups.
IFN-γ-independent intraocular tumor rejection is mediated by a macrophage-dependent process that leaves the eye intact
Authors: Coursey Terry G , Chen Peter W , Niederkorn Jerry Y 
Published: June 2012

Abstract
Intraocular tumors can undergo rejection by an IFN-γ-independent process that requires macrophages, leaving the eye in pristine condition.
Intraocular tumors reside in an immune-privileged site, yet in certain circumstances, they can undergo immune rejection. Ocular tumor rejection can follow one of two pathways. One pathway is CD4+ T cell-dependent and culminates in ischemic necrosis of the tumor and phthisis (atrophy) of the eye. A second pathway is also CD4+ T cell-dependent but does not inflict collateral injury to ocular tissues, and the eye is preserved. We isolated two clones of a murine tumor, Ad5E1 that undergo profoundly different forms of immune rejection in the eye. Clone 2.1 tumors undergo an ischemic necrotizing form of rejection that requires IFN-γ, T cells, and ocular macrophages and culminates in destruction of the eye. By contrast, the second clone of Ad5E1, clone 4, undergoes rejection that also requires T cells and ocular macrophages, but leaves the eye in pristine condition (nonphthisical rejection). Here, we demonstrate that nonphthisical tumor rejection of clone 4 tumors is IFN-γ-independent but requires an ocular macrophage population that contains M1 and M2 macrophages. Clone 4 tumor-bearing eyes displayed ten- and 15-fold increases in M2- and M1-associated markers Arg1 and NO2, respectively. This is in sharp contrast to previous results with clone 2.1 tumor rejection, in which M2 markers were undetectable, and the eye was destroyed. These results suggest that the presence of M2 macrophages tempers the immune rejection of intraocular tumors and promotes immune effectors that inflict minimal injury to innocent bystander cells and thereby preserve the integrity and function of the eye.
Multi-functional foot use during running in the zebra-tailed lizard (Callisaurus draconoides)
Authors: Li Chen , Hsieh S. Tonia , Goldman Daniel I. 
Published: June 2012

SummaryA diversity of animals that run on solid, level, flat, non-slip surfaces appear to bounce on their legs; elastic elements in the limbs can store and return energy during each step. The mechanics and energetics of running in natural terrain, particularly on surfaces that can yield and flow under stress, is less understood. The zebra-tailed lizard (Callisaurus draconoides), a small desert generalist with a large, elongate, tendinous hind foot, runs rapidly across a variety of natural substrates. We use high speed video to obtain detailed three-dimensional running kinematics on solid and granular surfaces to reveal how leg, foot, and substrate mechanics contribute to its high locomotor performance. Running at ~10 body length/s (~1 m/s), the center of mass oscillates like a spring-mass system on both substrates, with only 15% reduction in stride length on the granular surface. On the solid surface, a strut-spring model of the hind limb reveals that the hind foot saves about 40% of the mechanical work needed per step, significant for the lizard's small size. On the granular surface, a penetration force model and hypothesized subsurface foot rotation indicates that the hind foot paddles through fluidized granular medium, and that the energy lost during irreversible deformation of the substrate does not differ from the reduction in the mechanical energy of the center of mass. The upper hind leg muscles must perform three times as much mechanical work on the granular surface as on the solid surface to compensate for the greater energy lost within the foot and to the substrate.
Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes inDrosophila melanogaster
Authors: Lye Jessica C , Richards Christopher D , Dechen Kesang , Paterson David , de Jonge Martin D , Howard Daryl L , Warr Coral G , Burke Richard 
Published: June 2012

SummaryThe heavy metal zinc is an essential component of the human diet and is incorporated as a structural component in up to 10% of all mammalian proteins. The physiological importance of zinc homeostasis at the cellular level and the molecular mechanisms involved in this process have become topics of increasing interest in recent years. We have performed a systematic functional characterization of the majority of the predicted Drosophila Zip (Zinc/iron regulated transporter-related protein) and ZnT genes, using the Gal4-UAS system to carry out both ubiquitous and targeted over expression and suppression studies for thirteen of the seventeen putative zinc transport genes identified to date. We find that six of these thirteen genes may be essential for fly viability and that three of the remaining seven demonstrate over expression phenotypes. Our findings reaffirm the previously proposed function of dZnT63C (CG17723: FBgn005432) as an important zinc efflux protein and indicate that the fly homolog of hZip1, dZip42C.1 (CG9428: FBgn0033096), is a strong zinc importer in Drosophila. By combining over expression of dZip42C.1 with suppression of dZnT63C we were able to produce easily identifiable zinc toxicosis phenotypes which can be rescued or worsened by modifying dietary zinc content. Our findings show that a genetically based zinc toxicosis situation can be therapeutically treated or exacerbated by modifications to the diet, providing a sensitized background for future, more detailed studies of Zip / ZNT function.
Temperature compensation of aerobic capacity and performance in the Antarctic pteropod,Clione antarctica, compared to its northern congener,C. limacina
Authors: Dymowska Agnieszka K. , Manfredi Thomas , Rosenthal Joshua J. C. , Seibel Brad A. 
Published: June 2012

SummaryIn ectotherms living in cold waters, locomotory performance is constrained by a slower generation of the ATP that is needed to fuel muscle contraction. Both polar and temperate pteropods of the genus Clione, however, are able to swim continuously by flapping their parapodia (wings) at comparable frequencies, despite the latitudinal temperature gradient. Therefore, we expected polar species to have increased aerobic capacities in their wing muscles. We investigated muscle and mitochondrial ultrastructure of Clione antarctica from the Southern Ocean (-1.8ºC) and populations of a sister species, Clione limacina, from the Arctic (-0.5-3ºC) and from the N. Atlantic (10ºC). We also measured oxygen consumption and the activity of the mitochondrial enzyme citrate synthase (CS), in isolated wings of the two species. The Antarctic species showed a substantial up-regulation of the density of oxidative muscle fibers, but at the expense of fast-twitch muscle fibers. Mitochondrial capacity was also substantially increased in the Antarctic species, with the cristae surface density (58.2±1.3 µm2/µm3) more than twice that found in temperate species (34.3±0.8 µm2/µm3). Arctic C. limacina was intermediate between these two populations (43.7±0.5 µm2/µm3). The values for cold adapted populations are on par with those found in high-performance vertebrates. As a result of oxidative muscle proliferation, CS activity was 4-fold greater in C. antarctica wings than in temperate C. limacina when measured at a common temperature (20°C). Oxygen consumption of isolated wing preparations was comparable in the two species when measured at their respective habitat temperatures. These findings indicate complete compensation of ATP generation in wing muscles across a 10°C temperature range, which supports similar wing-beat frequencies during locomotion at each species' respective temperature. The elevated capacity in the wing muscles is reflected in whole-animal oxygen consumption and feeding rates.
Augmented Renal Clearance in the Critically Ill: How to Assess Kidney Function
Authors: Grootaert Veerle , Willems Ludo , Debaveye Yves , Meyfroidt Geert , Spriet Isabel 
Published: June 2012

BACKGROUND: Augmented renal clearance in critically ill patients can result in underdosing of life-saving drugs, potentially leading to therapeutic failure. To detect this phenomenon, correct assessment of the kidney function is essential. Currently, little is known about the validity of mathematical formulas to estimate renal function in this subset of patients. OBJECTIVE: To evaluate the validity of different methods to estimate kidney function in critically ill patients with augmented renal clearance by comparing measured renal clearance with estimated clearance using different formulas. METHODS: An observational, retrospective, single-center study was conducted in a 34-bed surgical intensive care unit (SICU) of the University Hospitals Leuven, Leuven, Belgium. Adults admitted to the SICU in 2010 with a measured creatinine clearance (CrCl) of 120 mL/min or more (based on 24-hour urinary collection) were included. The measured clearance values were compared with estimated clearance values as calculated by the Cockcroft-Gault (CrClCG) method and the re-expressed 4-variable Modification of Diet in Renal Disease estimated glomerular filtration rate (eGFR) formula. Spearman rank order correlation was performed to determine the relationship between measured and estimated clearances. Bland-Altman plots were evaluated to assess bias and limits of agreement between the 2 methods. RESULTS: Records on 1317 patients were screened. Augmented renal clearance was present in 390 patients. Spearman correlation showed fair correlation between measured and estimated clearances (rs = 0.343; p < 0.001 [CrClCG] and rs = 0.290; p < 0.001 [eGFR]). Bias was −11.2 mL/min with limits of agreement (–131.7; 109.3 mL/min [CrClCG]) and −19.9 mL/min with limits of agreement (–170.4; 130.7 mL/min [eGFR]). CONCLUSIONS: Estimated renal clearances, such as the eGFR estimated by the MDRD formula or CrCl estimated by CG, showed poor agreement with measured CrCl values in our critically ill population displaying augmented renal clearance. Clinicians should be cautious when interpreting kidney function based on estimating equations in this subset of patients. Instead, measured CrCl using urinary collection is recommended in patients suspected of displaying augmented renal clearance.
Effect of Cd(II) on the Ripening of Ferrihydrite in Alkaline Media
Authors: Alvarez Mariana , Horst María Fernanda , Sileo Elsa E. , Rueda Elsa H. 
Published: June 2012

AbstractTo acquire a better understanding of the influence exerted by the presence of Cd2+ during the process of transforming ferrihydrite to goethite, the morphological and structural changes of several samples obtained by the addition of Cd2+ to a suspension of nascent goethite were explored, and their chemical reactivity in acid media assessed. The samples (series Gi) were obtained by adding, at different times during the synthesis process, Cd2+ ions to ferrihydrite (Fe5HO8.4H2O) formed in alkaline media. The suspensions were aged for 5 days at 70°C, and the amorphous materials were extracted using a HCl solution (series GHCl-i). The X-ray diffraction (XRD) patterns showed that a goethite-like phase was formed, and chemical analyses indicated that the Cd content, xCd, increased with the earlier addition of the Cd2+ ions to the Fe oxyhydroxide suspension. Lattice parameters and cell volume, obtained by the Rietveld simulation of XRD data, indicated an enlargement of the cell parameters of goethite in line with the Cd-for-Fe substitution. In order to determine the influence of oxalate ions on the non-extracted solids, a second set of samples was also prepared that was kept in contact with an ammonium oxalate solution for 4 h (series Gox-i). The dissolution behavior of two series of Cd goethites and of a third series, obtained from coprecipitation of Fe3+ and Cd2+ ions in alkaline media, was observed. Kinetics measurements in 4 M HCl showed that the initial dissolution rate of samples Gox-i decreased with aging time, while the opposite effect was observed for series GHCl-i. Dissolution–time curves were well described by the Kabai equation, and activation energies were calculated using the Arrhenius equation. The results indicate that the presence of Cd during the crystallization process of goethite leads to the formation of a Cd goethite with modified morphology, structural parameters, and chemical reactivity.
The Effects of Salinity and Shear History on The Rheological Characteristics of Illite-Rich and Na-Montmorillonite-Rich Clays
Authors: Jeong Sueng Won , Locat Jacques , Leroueil Serge 
Published: June 2012

AbstractParticle–particle interactions in natural clays can be evaluated by their rheological behavior, but the results are often affected by the physicochemical properties of the clays. The behaviors of two fundamentally different types of clays (low-activity and high-activity) differ with respect to salinity and a time factor (duration of shearing at a given shear rate): illite-rich Jonquiere clay (low-activity clay, Canada) and montmorillonite-rich Wyoming bentonite (high-activity clay, USA). The purpose of the present study was to investigate these different behaviors. Most natural clays exhibit shear-thinning and thixotropic behavior with respect to salinity and the volumetric concentration of the solids. Natural clays also exhibit time-dependent non-Newtonian behavior. In terms of index value and shear strength, lowactivity and high-activity clays are known to exhibit contrasting responses to salinity. The geotechnical and rheological characteristics as a function of salinity and the shearing time for the given materials are compared here. The clay minerals were compared to estimate the inherent shear strengths, such as remolded shear strength (which is similar to the yield strength). Low-activity clay exhibits thixotropic behavior in a time-dependent manner. High-activity clay is also thixotropic for a short period of shearing, although rare cases of rheopectic behavior have been measured for long periods of shearing at high shear rates. The change from thixotropic to rheopectic behavior by bentonite clay has little effect at low shearing speeds, but appears to have a significant effect at higher speeds.
Ni Enrichment and Stability of Al-Free Garnierite Solid-Solutions: A Thermodynamic Approach
Authors: Galí S. , Soler J. M. , Proenza J. A. , Lewis J. F. , Cama J. , Tauler E. 
Published: June 2012

AbstractGarnierites represent significant Ni ore minerals in the many Ni-laterite deposits worldwide. The occurrence of a variety of garnierite minerals with variable Ni content poses questions about the conditions of their formation. From an aqueous-solution equilibrium thermodynamic point of view, the present study examines the conditions that favor the precipitation of a particular garnierite phase and the mechanism of Ni-enrichment, and gives an explanation to the temporal and spatial succession of different garnierite minerals in Ni-laterite deposits. The chemical and structural characterization of garnierite minerals from many nickel laterite deposits around the world show that this group of minerals is formed essentially by an intimate intermixing of three Mg-Ni phyllosilicate solid solutions: serpentine-népouite, kerolite-pimelite, and sepiolite-falcondoite, without or with very small amounts of Al in their composition. The present study deals with garnierites which are essentially Al-free. The published experimental dissolution constants for Mg end-members of the above solid solutions and the calculated constants for pure Ni end-members were used to calculate Lippmann diagrams for the three solid solutions, on the assumption that they are ideal. With the help of these diagrams, congruent dissolution of Ni-poor primary minerals, followed by equilibrium precipitation of Ni-rich secondary phyllosilicates, is proposed as an efficient mechanism for Ni supergene enrichment in the laterite profile. The stability fields of the solid solutions were constructed using [log aSiO2(aq), log ((aMg2+aNi2+)/(aH+)2)] (predominance) diagrams. These, combined with Lippmann diagrams, give an almost complete chemical characterization of the solution and the precipitating phase(s) in equilibrium. The temporal and spatial succession of hydrous Mg- Ni phyllosilicates encountered in Ni-laterite deposits is explained by the small mobility of silica and the increase in its activity.
Sorption of Naringin from Aqueous Solution by Modified Clay
Authors: Arellano-Cardenas Sofia , Gallardo-Velazquez Tzayhri , Poumian-Gamboa Gloria V. , Osorio-Revilla Guillermo , Lopez-Cortez Socorro , Rivera-Espinoza Yadira 
Published: June 2012

AbstractThe flavonoid naringin is the main source of the undesirable bitter taste in some citrus juices. In commercial debittering processes, the naringin is adsorbed on non-ionic polymeric resins. Organo-clays (OCs), which have been used as sorbents for organic pollutants, could also have affinity for the naringin molecule, and thus potentially could serve as a debittering agent. The objective of the present study was to characterize the sorption capacity of a prepared OC to evaluate its ability to remove naringin from aqueous solutions, investigating the effect of adsorbent dose, initial concentration of naringin, temperature, contact time, and pH. The OC was prepared by the intercalation of cationic surfactant hexadecyltrimethylammonium bromide in a Mexican bentonite. The host clay and the OC were characterized by X-ray diffraction, Fourier-transform infrared, and nitrogen gas adsorption. The OC showed a surface area of 9.3 m2 g-1, 11.35 nm average pore diameter, and a basal spacing, d001, of 2.01 nm. The adsorbent removed naringin at the rate of 60-72% at 25°C and pH 3. The sorption capacity increased with pH and temperature. Experimental data were well fitted by both Langmuir and Freundlich adsorption models. Most of the sorption took place during the first 10 min and the equilibrium time was reached within 720 min. The rate of sorption was adjusted to pseudo second-order kinetics.
Interlaboratory CEC and Exchangeable Cation Study of Bentonite Buffer Materials: I. Cu(II)-Triethylenetetramine Method
Authors: Dohrmann Reiner , Genske Dieter , Karnland Ola , Kaufhold Stephan , Kiviranta Leena , Olsson Siv , Plötze Michael , Sandén Torbjörn , Sellin Patrik , Svensson Daniel , Valter Martin 
Published: June 2012

AbstractBentonites are candidate materials for encapsulation of radioactive waste. The cation exchange capacity (CEC) has proved to be one of the most sensitive parameters for detecting changes of mineral properties such as swelling capacity and illitization in alteration experiments. Whether measured differences in CEC values of bentonite buffer samples before and after an experiment are (1) actual differences caused by clay structural changes such as illitization or (2) simply data scatter due to the different methods used by international research teams is an open question. The aim of this study was to measure the CEC of clay samples in five different laboratories using the same method and to evaluate the precision of the values measured. The Cu-trien method and four reference materials of the Alternative Buffer Material (ABM) test project in Äspö, Sweden, were chosen for this interlaboratory study. The precision of the Cu-trien method, which uses visible spectroscopy, was very good with a standard deviation of ±0.7–2.1 meq/100 g for CECs that ranged from 11 to 87 meq/100 g. For the same CEC range, analysis of Cu-trien index cations using inductively coupled plasma (mass spectrometry) and atomic absorption spectroscopy were less precise with a standard deviation of ±2.8–3.9 meq/100 g. Based on the measured precision, greater measured differences in Cu-trien CEC and exchangeable cation values of bentonite buffer samples, before and after an experiment, might be actual differences. Great care must be taken when interpreting measured CEC differences, and analytical characterization of any structural changes may be needed. Compared with results from the ‘International Soil-Analytical Exchange’ (iSE) program for soils, most absolute concentrations were much larger for the clays studied; however, for the two parameters exchangeable Ca2+ and CEC the range was similar to the iSE ring test and, most importantly, the precision was comparable. Future studies should discuss the accuracy of CEC and exchangeable cation values and compare them to alternative CEC methods in which care is taken to prevent dissolution of soluble minerals, such as calcite and gypsum.