bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations
Authors: Deng Kui , Pan Xiong‐Fei , Voehler Markus W. , Cai Qiuyin , Cai Hui , Shu Xiao‐Ou , Gupta Deepak K. , Lipworth Loren , Zheng Wei , Yu Danxia 
Published: May 2024

Background
Comprehensive blood lipoprotein profiles and their association with incident coronary heart disease (CHD) among racially and geographically diverse populations remain understudied.

Methods and Results
We conducted nested case–control studies of CHD among 3438 individuals (1719 pairs), including 1084 White Americans (542 pairs), 1244 Black Americans (622 pairs), and 1110 Chinese adults (555 pairs). We examined 36 plasma lipids, lipoproteins, and apolipoproteins, measured by nuclear magnetic resonance spectroscopy, with incident CHD among all participants and subgroups by demographics, lifestyle, and metabolic health status using conditional or unconditional logistic regression adjusted for potential confounders. Conventionally measured blood lipids, that is, total cholesterol, triglycerides, low‐density lipoprotein‐cholesterol, and high‐density lipoprotein‐cholesterol, were each associated with incident CHD, with odds ratios (ORs) being 1.33, 1.32, 1.24, and 0.79 per 1‐SD increase among all participants. Seventeen lipoprotein biomarkers showed numerically stronger associations than conventional lipids, with ORs per 1‐SD among all participants ranging from 1.35 to 1.57 and a negative OR of 0.78 (all false discovery rate <0.05), including apolipoprotein B100 to apolipoprotein A1 ratio (OR, 1.57 [95% CI, 1.45–1.7]), low‐density lipoprotein‐triglycerides (OR, 1.55 [95% CI, 1.43–1.69]), and apolipoprotein B (OR, 1.49 [95% CI, 1.37–1.62]). All these associations were significant and consistent across racial groups and other subgroups defined by age, sex, smoking, obesity, and metabolic health status, including individuals with normal levels of conventionally measured lipids.

Conclusions
Our study highlighted several lipoprotein biomarkers, including apolipoprotein B/ apolipoprotein A1 ratio, apolipoprotein B, and low‐density lipoprotein‐triglycerides, strongly and consistently associated with incident CHD. Our results suggest that comprehensive lipoprotein measures may complement the standard lipid panel to inform CHD risk among diverse populations.
A Critique of Chinese Loans in Sub-Saharan Africa: A fruitful Prospect or Neo-Colonisation
Authors: Muruko-Jaezuruka Veundjua , Birks Rubina 
Published: May 2024

Abstract
Economic development has been on Sub Sahara Africa’s (SSA) agenda for the past two decades. However, the stark reality is that it has been sporadic, slack and slow. One can argue that these nations had a late start due to their economies being controlled by conquerors until the late 20th century. Others might reinforce the idea that the late blooming of SSA was due to their economic development being stifled by the punitive interests levied by the IMF under the guise of reconstruction loans following decolonisation. Thus, in a bid to egress of that vicious circle of debt, another beacon has lit for SSA in the form of Chinese loans. Albeit, an acceptable macro reality that growth can be achieved through loans, this stance has raised moot questions: Is this financial help a strategy that will make SSA beholden to the Chinese government akin to a re-colonisation, or will it propel SSA nations into developed nations by alleviating poverty, creating jobs and promoting growth? The critical lesson of this paper is that confiscation of resources, in the event of non-payment of loans, should be solved with other measures of debt repayment to ensure the continent is not exposed to neo-colonisation.
Effects of core geometry, silica nanoparticles, and polyurethane foam on the mechanical properties of a novel circular-shaped core sandwich panels under compression test: Experimental study
Authors: Shaki Mohammad Hassan , Rostamiyan Yasser , Seyedi Seyed Masuod 
Published: May 2024

For the first time in this paper, a composite sandwich panel with a novel circular-shaped core reinforced with silica nanoparticles (SNPs) is designed and fabricated using the vacuum-assisted resin transfer molding (VARTM) method. Carbon fibers and epoxy resin are utilized to construct the composite sandwich panels, followed by polyurethane foam injection. After fabrication, the sandwich panels undergo uniform compression testing to examine their mechanical behavior and properties. In this study, the effects of various parameters, such as core length, core height, weight percentage (wt.%) of SNPs, and polyurethane foam, on the compressive strength of the structure are evaluated. To validate the results, a finite element simulation of the sandwich panel compression test is performed using ABAQUS software, and the results obtained are compared with experimental data, showing good agreement. The results of this research demonstrate that adding SNPs within a specific range results in a considerable enhancement of the structural strength. Adding SNPs up to 3% leads to approximately a 19% increase in the compressive strength of the structure. However, adding 4 wt.% SNPs results in a decrease of about 12% in the strength of the sandwich panel. Additionally, the core’s geometry significantly influences the control of compressive strength and rigidity of the sandwich panel. In other words, by increasing the core length, the compressive strength increases by 38%, while increasing the core height decreases compressive strength by about 30%. Also, it is found that adding polyurethane foam to the sandwich panel, despite a slight increase in weight, leads to a significant increase in compressive strength by about 32% and postpones its ultimate failure. Eventually, the hybrid specimen exhibits a strength approximately 57% greater than that of the pure foamless sandwich panel.
Tracking the 3-year trajectory of referrals to an early psychosis intervention service
Authors: Pitigala Nirupamal , Zeng Irene , Narayanan Nishanth , Cullum Sarah , Ng Lillian 
Published: May 2024

Aim To review the baseline and clinical characteristics of patients referred to a New Zealand Early Psychosis Intervention (EPI) service across a 4-year timeframe. Method We compared two cohorts, and identified variables associated with being accepted or declined, and reasons for decline, by an EPI service between 2013 and 2017. Results There were 576 people with suspected psychosis referred to the EPI service for assessment: 300 (52%) were accepted, 221 (38%) declined and 55 (10%) were not processed. Reasons for being declined by EPI services were a long duration of psychosis (DUP, 48%) and no evidence of psychosis (47%). There were no significant differences between the accepted and declined group in Emergency Department presentations for self-harm or suicide attempts and acute admissions to a psychiatric inpatient unit over the 3-year follow-up period. Conclusion To optimise the identification of true positive cases, EPI services require clear entry criteria. Replicating this study in other EPI services with different entry criteria may provide evidence to develop a more uniform screening process. Improved outcomes may be enhanced by measuring effectiveness and liaising with other EPI services.
Dynamic behavior of rack vehicle-track(rack) coupled system on super-large-slope bridges
Authors: Chen Zhaowei , Wang Lang , Zhang Mengqi 
Published: May 2024

Rack railways are mainly used in mountainous areas, where inevitably, super-large-slope bridge structures appear. The dynamic behavior of the rack vehicle-track(rack) coupled system on super-large-slope bridge is rarely studied. To address this issue, a dynamic interaction model for rack vehicle-track(rack)-bridge system is established by considering the detailed dynamic meshing behavior of gear-rack and the dynamic contact behavior of the wheel-rail. On this basis, the gear-rack meshing force and the wheel-rail contact force of rack vehicles are studied under lines with varying slopes, and the dynamic behavior of the rack vehicle and the track-bridge system with a slope of 250‰ is further analyzed. Research results show that as the slope line increases, the gear and rack meshing force increases, but the wheel-rail vertical force decreases. Concurrently, the stability index of the vehicle changed considerably, and the stability of the vehicle decreases substantially. The maximum values of the vibration acceleration of the vehicle body and bridge are 0.4 m/s2 and 0.5 m/s2, respectively, meeting the requirements of the relevant standards for the vibration acceleration of the vehicle body and bridge. Further analysis reveals that the vibration of rack is mainly affected by the meshing force, and the vibration of the bridge is mainly affected by the wheel-rail force. These research results can offer a theoretical basis for the pre-design, post-operation, and maintenance of rack railways.
A study of multi-acoustic black holes considering suitability of attachment positions for suppressing low-frequency vibrations on large motor
Authors: Choi Hyun-Gyu , Hong Suk-Yoon , Song Jee-Hun , Lee Chan-Hui , Choi Yo-Seb 
Published: May 2024

Vibrations generated from machinery in various industries, such as the automotive, aerospace, and shipbuilding industries, must be suppressed for developing low-vibration and low-noise systems. High-frequency vibrations can be easily controlled via damping treatments; however, controlling vibrations in the low-frequency range generated from large machinery is a major challenge. In general, a substantial amount of damping material is required for suppressing low-frequency vibrations. This is unsuitable when developing low-cost, lightweight, and eco-friendly systems. To overcome the limitations, effective methods are required for suppressing these low-frequency vibrations. In this study, an effective method was proposed for suppressing vibrations in the low-frequency range using multiple acoustic black holes (multi-ABHs) considering the suitability values of the attachment positions, which were determined by flexural wave propagation and interactions between the multi-ABHs and structures. The suitability values of the attachment positions are proposed as non-dimensional parameters that are calculated using the structural intensity and mode superposition methods. For validating the proposed method, the vibration suppression characteristics were analyzed using a steel plate. The analyzed cases were categorized into six groups according to the suitability values of the attachment positions of the multi-ABHs. The largest reduction in vibrations was observed when the multi-ABHs were attached to the location with the highest suitability in the six cases. Finally, the multi-ABHs were applied to a large 2-pole motor considering the suitability values of the attachment positions, and the dominant vibrations at 60, 120, and 180 Hz frequencies were suppressed.
Telehealth-delivered parent-based sleep-focused intervention for insomnia in preschool children with autism spectrum disorder: A randomized controlled study
Authors: Ip Brian Yee Ting , Lee So-Lun , Li Shirley Xin 
Published: May 2024

Sleep problems are common in children with autism spectrum disorder. Although previous research has shown the positive effects of parent-based sleep intervention, it was mainly focused on face-to-face modality, which might limit accessibility. This study aimed to examine the efficacy of a telehealth-delivered parent-based sleep-focused intervention in treating insomnia in preschool children with autism spectrum disorder. A total of 62 parents/caregivers with a child with autism spectrum disorder and comorbid insomnia (aged 3–6 years) were randomized to receive either three weekly group sessions of sleep-focused intervention via Zoom with telephone support ( n = 30) or treatment as usual ( n = 32). The intervention group had significantly greater improvements in overall sleep problems (Children’s Sleep Habit Questionnaire total score; p < 0.05), bedtime resistance ( p < 0.05), and sleep-onset delay ( p < 0.05) at post-treatment as compared to the treatment as usual group. The intervention group also showed significant improvements in overall behavioral and emotional problems ( p < 0.05), especially externalizing problems ( p < 0.05) as measured by Strengths and Difficulties Questionnaire, and parental stress level ( p < 0.05) as measured by Depression, Anxiety and Stress Scale-21 as compared to the treatment as usual group (partial η2 = 0.081–0.101). The findings supported the feasibility and promising effects of a brief parent-based sleep intervention delivered via telehealth. Lay abstract Sleep problems are common in children with autism spectrum disorder. Although the effects of parent-based sleep intervention were shown to be promising, previous research was limited to the face-to-face service model, which might limit accessibility. This study examined a sleep-focused parent training group delivered via telehealth for treating insomnia in preschool children with autism spectrum disorder, which allowed parents to join the intervention remotely. Results showed that children in the intervention group had greater improvements in sleep and insomnia symptoms after treatment, as compared to those who only received care as usual. This sleep-focused treatment also led to improved daytime behaviors, especially externalizing problems such as hyperactivity and conduct problems, in children with autism spectrum disorder. Parents who had attended the training also reported reduced parental stress level after treatment. The findings supported the feasibility and promising effects of a brief parent-based sleep intervention delivered via telehealth for preschooler with autism spectrum disorder.
Does the Subtalar or Tibiotalar Joint Need Fused in Primary Retrograde Tibiotalocalcaneal Nailing for Fragility Ankle Fractures?
Authors: DeGenova Daniel T. , Hill Zachary P. , Hoffman Adam D. , Taylor Avery R. , Dues Boston , Faherty Mallory , Taylor Benjamin C. 
Published: May 2024

Background. As an alternative to traditional open reduction internal fixation of ankle fragility fractures, primary retrograde tibiotalocalcaneal (TTC) nailing has been investigated as a treatment option. These results suggest that this treatment is an acceptable alternative treatment option for these injuries. There are still questions about the need for formal joint preparation at the subtalar or tibiotalar joint when performing primary TTC nailing for fragility fractures. Methods. In this study, we retrospectively evaluated 32 patients treated with primary retrograde TTC nail without subtalar or tibiotalar joint preparation for a mean of 2.4 years postoperatively. We specifically reviewed the charts for nail breakages at either joint, patients developing subtalar or tibiotalar joint pathology requiring additional treatment, including return to the operating room for formal joint preparation. Results. Fracture union occurred in 100% of patients. There were 3 cases (10.0%) of hardware failure, and 2 of these cases were asymptomatic and did not require any treatment. One patient (3.3%) developed hardware failure with nail breakage at the subtalar joint. This patient developed progressive pain and symptoms requiring revision surgery with formal arthrodesis of the subtalar and tibiotalar joint. Conclusions. This study shows that retrograde hindfoot nailing without formal subtalar or tibiotalar joint preparation is an acceptable potential treatment option in ankle fragility fractures. Mid-term follow-up demonstrates favorable outcomes without the need for formal joint preparation in this high-risk population. Comparative studies with higher patient numbers and long-term follow-up are needed to confirm the results of this study. Levels of Evidence: Level IV.
Willingness to support neighbours practically or emotionally: a cross-sectional survey among the general public
Authors: Quintiens Bert , Smets Tinne , Chambaere Kenneth , Van den Block Lieve , Deliens Luc , Cohen Joachim 
Published: May 2024

Background: Wider social networks are increasingly recognized for supporting people with care needs. Health-promoting initiatives around the end of life aim to foster these social connections but currently provide little insight into how willing people are to help neighbours facing support needs. Objectives: This study describes how willing people are to help neighbours who need support practically or emotionally, whether there is a difference in willingness depending on the type of support needed and what determines this willingness. Design: We applied a cross-sectional survey design. Methods: We distributed 4400 questionnaires to a random sample of people aged >15 across four municipalities in Flanders, Belgium. These surveys included attitudinal and experiential questions related to serious illness, caregiving and dying. Respondents rated their willingness (scale of 1–5) to provide support to different neighbours in hypothetical scenarios: (1) an older person in need of assistance and (2) a caregiver of a dying partner. Results: A total of 2008 questionnaires were returned (45.6%). The average willingness to support neighbours was 3.41 (case 1) and 3.85 (case 2). Helping with groceries scored highest; cooking and keeping company scored lowest. Factors associated with higher willingness included an optimistic outlook about receiving support from others, family caregiving experience and prior volunteering around serious illness or dying. Conclusion: People are generally willing to support their neighbours who need help practically or emotionally, especially when they have prior experience with illness, death or dying and when they felt supported by different groups of people. Community-based models that build support around people with care needs could explore to what extent this willingness translates into durable community support. Initiatives promoting social connection and cohesion around serious illness, caregiving and dying may harness this potential through experiential learning.
A practical approach to the modern diagnosis and classification of T- and NK-cell lymphomas
Authors: de Leval Laurence , Gaulard Philippe , Dogan Ahmet 
Published: May 2024

Abstract
T- and natural killer (NK)-cell lymphomas are neoplasms derived from immature T cells (lymphoblastic lymphomas), or more commonly, from mature T and NK cells (peripheral T-cell lymphomas, PTCLs). PTCLs are rare but show marked biological and clinical diversity. They are usually aggressive and may present in lymph nodes, blood, bone marrow, or other organs. More than 30 T/NK-cell–derived neoplastic entities are recognized in the International Consensus Classification and the classification of the World Health Organization (fifth edition), both published in 2022, which integrate the most recent knowledge in hematology, immunology, pathology, and genetics. In both proposals, disease definition aims to integrate clinical features, etiology, implied cell of origin, morphology, phenotype, and genetic features into biologically and clinically relevant clinicopathologic entities. Cell derivation from innate immune cells or specific functional subsets of CD4+ T cells such as follicular helper T cells is a major determinant delineating entities. Accurate diagnosis of T/NK-cell lymphoma is essential for clinical management and mostly relies on tissue biopsies. Because the histological presentation may be heterogeneous and overlaps with that of many benign lymphoid proliferations and B-cell lymphomas, the diagnosis is often challenging. Disease location, morphology, and immunophenotyping remain the main features guiding the diagnosis, often complemented by genetic analysis including clonality and high-throughput sequencing mutational studies. This review provides a comprehensive overview of the classification and diagnosis of T-cell lymphoma in the context of current concepts and scientific knowledge.
Hot under the clot: venous thrombogenesis is an inflammatory process
Authors: Rayes Julie , Brill Alexander 
Published: May 2024

Abstract
Venous thrombosis (VT) is a serious medical condition in which a blood clot forms in deep veins, often causing limb swelling and pain. Current antithrombotic therapies carry significant bleeding risks resulting from targeting essential coagulation factors. Recent advances in this field have revealed that the cross talk between the innate immune system and coagulation cascade is a key driver of VT pathogenesis, offering new opportunities for potential therapeutic interventions without inducing bleeding complications. This review summarizes and discusses recent evidence from preclinical models on the role of inflammation in VT development. We highlight the major mechanisms by which endothelial cell activation, Weibel-Palade body release, hypoxia, reactive oxygen species, inflammasome, neutrophil extracellular traps, and other immune factors cooperate to initiate and propagate VT. We also review emerging clinical data describing anti-inflammatory approaches as adjuncts to anticoagulation in VT treatment. Finally, we identify key knowledge gaps and future directions that could maximize the benefit of anti-inflammatory therapies in VT. Identifying and targeting the inflammatory factors driving VT, either at the endothelial cell level or within the clot, may pave the way for new therapeutic possibilities for improving VT treatment and reducing thromboembolic complications without increasing bleeding risk.
How I use next-generation sequencing–MRD to plan approach and prevent relapse after HCT for children and adults with ALL
Authors: Muffly Lori , Liang Emily C. , Dolan J. Gregory , Pulsipher Michael A. 
Published: May 2024

Abstract
Measurable residual disease (MRD) evaluation by multiparameter flow cytometry (MFC) or quantitative polymerase chain reaction methods is an established standard of care for assessing risk of relapse before or after hematopoietic cell transplantation (HCT) for acute lymphoblastic leukemia (ALL). Next-generation sequencing (NGS)–MRD has emerged as a highly effective approach that allows for the detection of lymphoblasts at a level of &lt;1 in 106 nucleated cells, increasing sensitivity of ALL detection by 2 to 3 logs. Early studies have shown superior results compared with MFC and suggest that NGS-MRD may allow for the determination of patients in whom reduced toxicity transplant preparative approaches could be deployed without sacrificing outcomes. Many centers/study groups have implemented immune modulation approaches based on MRD measurements that have resulted in improved outcomes. Challenges remain with NGS-MRD, because it is not commercially available in many countries, and interpretation of results can be complex. Through patient case review, discussion of relevant studies, and detailed expert opinion, we share our approach to NGS-MRD testing before and after HCT in pediatric and adult ALL. Improved pre-HCT risk classification and post-HCT monitoring for relapse in bone marrow and less invasive peripheral blood monitoring by NGS-MRD may lead to alternative approaches to prevent relapse in patients undergoing this challenging procedure.