bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERFIL LIPÍDICO DE MILITARES CONTROLADORAS DE TRÁFEGO AÉREO NO PERÍODO DE 2013 A 2018
Authors: Benedetto Pamella , Mancini Rodrigues S. de Paiva Valente Janiny , Geralda Ferreira Fabrícia , Aparecida Doimo Leonice 
Published: May 2024

Introdução: O trabalho de controladores de tráfego aéreo (CTA) tem como uma das principais características o constante estado de alerta. As condições e o ambiente de trabalho podem favorecer o aparecimento de agravos à saúde, dentre eles os indicadores de doenças cardiovasculares. Objetivo: Verificar o perfil lipídico de mulheres, todas militares da ativa da Força Aérea Brasileira, no período de 2013 a 2018. Métodos: Estudo retrospectivo, com dados secundários de 79 prontuários médicos. Considerou-se dados de idade, massa corporal, estatura e medidas do perfil lipídico: colesterol total (CT), Low-density lipoprotein cholesterol (LDL-c), High-density lipoprotein cholesterol (HDL-c) e triglicerídeo (TG). Calculou-se o índice de massa corporal (IMC) e as razões CT/ HDL-c, LDL-c/HDL-c e TG/HDL-c. Realizou-se verificação da normalidade e posteriormente análise descritiva e inferencial considerando como significante valores de p < 0,05. Resultados: Foram avaliadas 79 CTA, sendo 41 no ano de 2013, 35 em 2014, 48 em 2015, 54 em 2016, 27 em 2017 e 24 em 2018. De 2015 em diante, a maioria das CTA são classificadas com excesso de peso. Em relação ao perfil lipídico, observou-se que, ao longo dos seis anos, a maior parte das mulheres está com colesterol total alterado. Os valores de triglicerídeos apresentaram diferença estatística ao longo dos anos com prevalência de inadequação superior a 20%. Observou-se otimização da relação entre as concentrações de colesterol total, HDL-c e LDL-c. Quanto a razão TG/ HDL-c houve diferença significativa entre o ano de 2018 e os demais, sendo que, em 2018, mais de 30% da amostra apresentou razão elevada. Conclusão: As CTA apresentaram excesso de peso corporal e alterações negativas no perfil lipídico no período considerado. Sugere-se conduzir estudos com as CTA que atuam em diferentes locais no Brasil para melhor traçar o perfil lipídico deste grupo.
Participation of the defender according to 1864 Regulations of Criminal Procedure
Authors: Scherbakova A. A. 
Published: May 2024

In connection with the adoption of the Regulations of Criminal Proceedings, it became possible to study and study the procedural status of participants in criminal proceedings, including the defense lawyer. In this connection, the author examines his procedural status from the perspective of the rights and obligations available during the period under review, and also analyzes the possibility of him realizing his criminal procedural function. Examining the norms of the Regulations of Criminal Proceedings, the author comes to the conclusion that the defense attorney could enter into a criminal case by appointment or invitation, and had both his own rights and those granted to the parties as a whole. At the same time, the rights of the defense attorney, as a rule, correlate with the rights of the defendant, and the rules of law emphasize the simultaneous participation of the defense attorney and the defendant.The purpose of this article is to examine the position of the institution of defence during the period of duration of the significant document in the sphere of russian criminal procedure — Regulations of Criminal Proceedings. In this article the object of consideration is the legal rules of the Regulations of Criminal Proceedings, which the participation of the defender in criminal cases is subject to. As an example, the author gives legal practice of the Councils of Barristers, which could clarify the provisions of the Charter of Criminal Proceedings regarding the participation of a defense attorney in criminal cases
O ensino de ciências e a educação étnico-racial: uma revisão sistemática da literatura
Authors: Maria Bueno da Cunha Eliete , Maria Tavares Nunes Simara 
Published: May 2024

Neste trabalho, foi realizada uma Revisão Sistemática da Literatura (RSL) a respeito das produções científicas desenvolvidas entre 2011 a 2023 acerca da interface entre o Ensino de Ciências e a Educação Étnico-Racial no escopo da Educação Básica. Essa revisão se deu por compreender que o Ensino de Ciências deve promover uma formação crítica e emancipatória do sujeito, sendo assim papel do ensino de Ciências o combate ao racismo estruturado no âmbito escolar e social. Para a RSL, foi utilizada como fonte de dados a Plataforma de Pesquisa “Portal de Periódicos CAPES”, um dos maiores acervos científicos virtuais do Brasil. A pesquisa revelou uma defasagem de materiais com relação à associação das duas temáticas estudadas, uma vez que poucos resultados foram encontrados no que se refere à produção de estudos dos dois assuntos em evidência, demonstrando assim, um ponto crítico da investigação. Isso deixa claro a necessidade de se realizar mais trabalhos e investigações que contribuam para essa temática tão necessária de ser trabalhada na sala de aula, pois a escassez de estudos foi uma limitação encontrada no decorrer desta pesquisa.
Formation and analysis technical-economic model of transformation electricity with applying criterion method
Authors: Cherkashyna Veronika Viktorivna , Baklytskyi Vladyslav Mykolayovych 
Published: May 2024

The article presents the formation technical-economic model of electricity transformation in accordance with the strategy of development electric power industry in Ukraine. In connection with the renewal of the values included in the strategy of development of electric networks of Ukraine, there is a need to find the most optimal characteristics of power transformers. To implement this task, it is advisable to use a technical-economic model that has a minimum of objective function, which allows to make economically feasible and reasonable decisions about the parameters of transformers in the design of electrical networks. To fulfill this task, the process of forming a technical-economic model, which allows its analysis by the criterion method. The process of forming the technical-economic model is performed on the basis of technical characteristics of two-winding transformers with a higher voltage of 110 kV in the power range from 10 to 63 MVA. Given the initial technical-economic model, which simplified by approximating the main components by power functions using the least squares method. Given the main conditions used to find the approximation coefficients. Graphs are constructed on the basis of the found approximation coefficients, which allow to estimate the accuracy of the approximation, comparing the approximated values of the parameters of power transformers and the values of the parameters of existing power transformers. The graphs also indicate the key components that affect the overall cost of electricity transformation costs. Presented an algorithm for finding similarity criteria using indicators of the degree of basic approximable parameters. Transformations of the technical-economic model have been performed, which allow to analyse the costs of electricity transformation using the criterion method. Found indicators of similarity criteria on the basis of which the technical-economic model is presented in the criterion form. The reliability of the obtained similarity criteria was assessed by comparing the values of the ratios of the components in the technical-economic model and the ratio obtained on the basis of the similarity criteria. It is substantiated that the obtained similarity criteria, on the first approximation, can be considered close in values to the existing relations.
Single-cell transcriptomic landscape deciphers olfactory neuroblastoma subtypes and intra-tumoral heterogeneity
Authors: Yu Hongmeng 
Published: May 2024

Abstract

Olfactory neuroblastoma (ONB) is a rare malignancy known to originate from the olfactory epithelium. The complex tumor ecosystem of this pathology remains unclear. Here we explored the cellular components within 10 ONB tumors and 1 olfactory mucosa sample based on single cell RNA profiles. We showed the intra-tumoral heterogeneity by identifying five unique expression programs among malignant epithelial cells. A novel three-classification system (Neural/Basal/Mesenchymal) of ONB was established according to the distinguished gene expression patterns. Biomarkers for categorizing bulk tumors into the new subtypes were elucidated. Different responses towards certain chemotherapy regimens could be cautiously inferred according to the molecular features representing three tumor types,thus helping with precision chemotherapy. Herein, we also analyzed subclusters of tumor microenvironment (TME) and the interactions among different cell types in the TME. Relative abundance of immunosuppressive tumor associated macrophages indicated the benefits of immunotherapies targeting macrophages.
Prophages in the infant gut are induced and modulate the functionality of their hosts
Authors: Shah Shiraz , Redgwell Tamsin , Thorsen Jonathan , Petit Marie-Agnès , Deng Ling , Vestergaard Gisle , Russel Jakob , Chawes Bo , Bonnelykke Klaus , Bisgaard Hans , Nielsen Dennis , Sørensen Søren , Stokholm Jakob 
Published: May 2024

Abstract

Background
Gut microbiome (GM) composition and function plays a pivotal role in human health and disease. The gut virome is increasingly being recognised as an important GM player and has been implicated in disease states. However, these studies largely focus on free phages in adults. Here we identify prophages from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother-child cohort and investigate their potential functions.
Results
We identified 10645 putative prophages as viral Operational Taxonomic Units (vOTUs) from 662 assembled metagenomes. No core provirome was found: the most prevalent vOTU was identified in ~ 70% of the samples. The most abundant and second most prevalent group of vOTUs in the cohort was a novel cluster closely related to Bacteroides phage Hanky p00’. Functional annotation of this cluster revealed the presence of genes in the dTDP-L-rhamnose pathway, possibly involved in the production of capsular polysaccharides. We also found an abundance of diversity generating retroelements in this cluster. Additionally, paired shotgun virome data allowed us to show that most prophages are induced in at least one sample and that induction is not affected by antibiotics in the 4 weeks prior to sampling.
Conclusions
Prophages in the infant gut are largely unique to the individual and generally not shared. Most of them appear to be induced and so may be key drivers in shaping the bacterial microbiome. The most abundant cluster of prophages in the infant gut is novel and possesses elements that may allow maintaining differentially susceptible subpopulations of their host bacterium; whilst also containing diversity generating retroelements that could expand their host range. In summary, prophages are important components of the infant gut that may have far reaching influences on the composition and function of the microbiome.
Dermal adipogenesis protects against neutrophilic skin inflammation
Authors: Zhang Ling-juan , Zhang Ling-juan , Zhang Ling-juan , Xia Tian , Xia Tian , Xia Tian , Zhang Wenlu , Zhang Wenlu , Zhang Wenlu , Wu Rundong , Wu Rundong , Wu Rundong , Zhang Xiaowei , Zhang Xiaowei , Zhang Xiaowei , Xia Rongshuang , Xia Rongshuang , Xia Rongshuang , Hu Xiao , Hu Xiao , Hu Xiao , Wu Shuai , Wu Shuai , Wu Shuai , Liao Yanhang , Liao Yanhang , Liao Yanhang , Li Jiacheng , Li Jiacheng , Li Jiacheng , Liu Youxi , Liu Youxi , Liu Youxi , Liu Yiman , Liu Yiman , Liu Yiman , Guo Zhuolin , Guo Zhuolin , Guo Zhuolin , Zhang Chi , Zhang Chi , Zhang Chi , Chen Ming , Chen Ming , Chen Ming , Lu Jiajing , Lu Jiajing , Lu Jiajing , Shi Yuling , Shi Yuling , Shi Yuling 
Published: May 2024

Abstract

The skin’s immune response to danger signals involves rapid recruitment of neutrophils, but their excessive accumulation leads to inflammatory skin diseases, such as psoriasis, and how skin resident cells tolerate neutrophilic inflammation is poorly understood. Dermal white adipose tissue (dWAT) is an emerging component of the skin's immune barrier, but its role in controlling skin inflammation remains under-studied. Here, using an imiquimod-induced psoriasis mouse model, we observed a dynamic coupling between dermal adipogenesis, neutrophil infiltration and regression. During the early inflammatory phase, dWAT repopulates with PDGFRA+ preadipocytes that secrete CXCL1 and SAA3, attracting and activating CXCR2+ neutrophils. These neutrophils further activate preadipocytes through IL1β-IL1R signaling, establishing a self-sustaining inflammatory loop. Prolonged activation of pAds triggers PPARγ-dependent adipogenesis, leading to the formation of early adipocytes that secrete lipids exerting potent anti-inflammatory activity against myeloid cells, thereby aiding in inflammation resolution. Inhibition of adipogenesis, via targeted inhibition of PPARγ, through either pharmacological or genetic approaches, disrupts the formation of early adipocytes and prevents neutrophil regression and inflammation resolution. Analysis of human psoriatic cells identified a dFB subpopulation enriched with preadipocyte, IL1-pathway, and inflammatory gene signatures. Furthermore, transcriptomic analyses revealed a negative correlation between neutrophil-related inflammatory response with dermal adipogenesis response in generalized pustular psoriasis. Together, this study highlights the distinct roles of adipogenic fibroblasts and early adipocytes in initiating and resolving skin inflammation and suggests that promoting the differentiation of proinflammatory fibroblasts into anti-inflammatory early adipocytes could open avenues for the treatment of neutrophil-related inflammatory skin diseases, such as psoriasis and ulcers.
Comprehensive Assessment of Glaucoma in Patients with High Myopia: A Systematic Review and Meta-analysis with a Discussion on Structural and Functional Imaging Modalities
Authors: Quiroz-Reyes Miguel A. , Quiroz-Gonzalez Erick A. , Quiroz-Gonzalez Miguel A. , Lima-Gomez Virgilio 
Published: May 2024

Abstract

Purpose: The interplay between myopia and glaucoma has gained attention, with escalating myopia demonstrating a significant association with increased POAG rates, particularly in patients with severe myopia. This systematic review aimed to comprehensively analyze the relationship between myopia and glaucoma, focusing on the structural and functional implications, risk factors, and assessment modalities, particularly optical coherence tomography (OCT), in highly myopic populations.
Methods: According to the PRISMA guidelines, a meticulous search strategy was employed across multiple databases from 2012 to 2024. The inclusion criteria included individuals aged 18 years or older with myopia exceeding 6 diopters or an axial length > 26 mm who were diagnosed with chronic glaucoma. Various study designs, including randomized controlled trials (RCTs), prospective cohort studies, and observational studies, were incorporated. Quality assessment was performed using the Jadad Scale, and statistical analyses were performed to summarize the study characteristics and outcomes.
Results: Of the 350 initial articles, 15 met the inclusion criteria. OCT assessments revealed structural changes such as thinning of the retinal nerve fiber layer preceding functional losses. Meta-analyses demonstrated a heightened risk of POAG with increasing myopia severity, showing a significant nonlinear relationship. In this meta-analysis of six studies involving 3,040 patients, we demonstrated a relationship between myopia and glaucoma (OR = 12.0, 95% CI: 10.1–4.7, P <0.00001).
Conclusion: This comprehensive analysis consolidates the evidence of the relationship between myopia and glaucoma, emphasizing the pivotal role of OCT and other imaging modalities in early detection and monitoring.
Anomaly Detection Algorithm for Elliptical Clusters Based On Maximum Cluster Diameter Criteria
Authors: Bipin Pearl 
Published: May 2024

Abstract

Anomaly detection, a fundamental task in data analysis, requires robust mathematical frameworks. We present to you a pioneering anomaly detection algorithm poised to redefine the landscape of data analysis. Within this study, we introduce a novel approach meticulously tailored to the nuanced characteristics of elliptical clusters, showcasing an integration of sophisticated geometric and statistical methodologies. Leveraging robust mathematical frameworks, our algorithm transcends conventional boundaries, promising unprecedented levels of accuracy and efficiency in anomaly detection tasks. Through the convergence of theoretical insights and practical applications, our research heralds a paradigm shift in the domain of data analytics, offering a profound advancement in the identification and interpretation of anomalous data points within complex datasets.
Subject Descriptors: Anomaly Detection, Data Clustering
Categories: I.2.10 [Artificial Intelligence]: Vision and Scene Understanding—Statistical Methods
Network Pharmacology, Molecular Docking, and Experimental Validation on Guiluoshi Anzang Decoction Against Premature Ovarian Insufficiency
Authors: Wu Yuanyuan , Long Yunxia , Su Guangheng , Fan Xiangping , He Guozhen , Luo Zhijuan , Luo Songping 
Published: May 2024

Background and Objectives:
Premature Ovarian Insufficiency (POI) is a disease suffered
by women under the age of 40 when ovarian function has declined, seriously affecting both
the physical and mental health of women. Guiluoshi Anzang decoction (GLSAZD) has been
used for a long time and has a unique therapeutic effect on improving ovarian function. This
study aims to investigate the mechanism of GLSAZD in treating POI through network pharmacology,
molecular docking, and experimental verification.

Methods::
In this study, the active ingredients of Guiluoshi Anzang Decoction and the targets of
POI were obtained from TCMSP, BATMANN-TCM, Uniprot, GeneCards, and other databases,
and network pharmacology analysis was performed. Molecular docking was conducted to validate
the affinity of the main active ingredient of GLSAZD to key POI targets. A POI SD rat
model was established, and HE staining, ELISA, Real-time PCR, and Western blot experiments
were performed to verify the predicted core targets and the therapeutic effects.

Results::
10 core targets and the top 5 ingredients were screened out. Molecular docking showed
core targets AKT1, CASP3, TNF, TP53, and IL6 had stable binding with the core 5 ingredients
quercetin, kaempferol, beta-sitosterol, luteolin, and Stigmasterol. GO and KEGG enrichment
analysis demonstrated the mechanism involved in the positive regulation of gene expression,
PI3K-AKT signaling pathway, and apoptosis signaling pathways. Animal experiments indicated
GLSAZD could up-regulate the protein expression of p-PI3K and p-AKT1 and the mRNA expression
of STAT3 and VEGF, down-regulate TP53 and Cleaved Caspase-3 protein expression
in rat`s ovarian tissues and serum TNF-α and IL-6 protein levels, activate PI3K-AKT signaling
pathway and inhibit the apoptosis signaling pathway.

Conclusion::
GLSAZD treats POI through multi-component, multi-target, and multi-pathway approaches.
This study provided evidence for its clinical application in treating POI and shed light
on the study of traditional medicine of the Guangxi Zhuang Autonomous Region in China.
Environmental Efficiency of Monsoon Rice (Oryza sativa) Production between Transplanting and Broadcasting Sowing Methods in Myanmar
Authors: Moe Myint Myat , Bunyasiri Isriya , Sirisupluxna Prapinwadee 
Published: May 2024

Introduction
Myanmar relies on rice for its food security and economic significance, ranking seventh in the world for rice exports as of 2021. The most significant concern in rice production is exceeding the recommended nitrogen (N) fertilizer usage rate. Nitrogen is a crucial fertilizer for rice production, but it poses negative environmental consequences, such as nitrous oxide emissions. Therefore, this study intended to assess the technical (TE) and environmental efficiency (EE) of monsoon rice production in Myanmar and compare the efficiencies of broadcasting (BC) and transplanting (TP) sowing methods.

Methods
A translog stochastic frontier production function approach estimated the output-oriented technical efficiency and environmental efficiency of monsoon rice production. The study conducted face-to-face interviews with 317 farmers in Nay Pyi Taw Union Territory, Myanmar.

Results
The overall mean TE and EE were 81% and 23%, respectively. The average TE and EE for N fertilizer were 84% and 35% using the TP method and 80% and 20% using the BC method, respectively.

Conclusion
Our findings confirmed that the TP method was technically and environmentally superior to the BC method. The adoption of the TP method should be promoted by highlighting its positive impacts on achieving sustainable monsoon rice production in Myanmar.
Investigating the Professional Commitment and its Correlation with Patient Safety Culture and Patient Identification Errors: Evidence from a Cross-Sectional Study from Nurses' Perspectives
Authors: Mehralian Gholamhossein , Yusefi Ali Reza , Ahmadinejad Parvin , Bahmaei Jamshid , Bordbar Shima 
Published: May 2024

Introduction
Nurses' professional commitment is crucial to their qualifications, impacting patient safety. This study aims to explore the relationship between nurses' professional commitment and patient safety culture, specifically focusing on patient identification errors.

Methods
A cross-sectional study was conducted in 2022 involving 340 nurses working in educational medical hospitals in southern Iran. Data collection instruments included questionnaires on nurses' professional commitment, patient identification errors, and patient safety culture. Descriptive and inferential statistics, such as t-tests, ANOVA, Pearson's correlation coefficient, and multiple linear regression, were performed using SPSS software version 23, with a significance level set at p = 0.05.

Results
The mean scores for professional commitment, patient safety culture, and errors in patient identification, as perceived by the nurses, were 77.64 ± 14.32 (out of 130), 2.71 ± 0.78 (out of 5), and 16.41 ± 4.58 (out of 32), respectively. There was a statistically significant correlation between professional commitment and errors in patient identification (r = -0.577, p < 0.001) as well as patient safety culture (r = 0.456, p < 0.001). Regression analysis revealed that nursing job satisfaction, understanding of nursing, self-sacrifice for the nursing profession, and engagement with the nursing profession were predictors of patient safety culture and errors in patient identification (p < 0.05).

Conclusion
Nurses' professional commitment was found to be at a moderate level. Furthermore, the dimensions of professional commitment significantly influenced patient safety culture and errors in patient identification. To enhance nurses' professional commitment, and subsequently improve patient safety culture and reduce identification errors, it is recommended to implement management mechanisms that increase job satisfaction, understanding, engagement, and professional self-sacrifice among nurses.