bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Use of Serious Games for Cancer Control Among Children and Adolescents: Scoping Review
Authors: Kim Sunghak , Wilson Paije , Abraham Olufunmilola 
Published: May 2024

Background
Effective health care services that meet the diverse needs of children and adolescents with cancer are required to alleviate their physical, psychological, and social challenges and improve their quality of life. Previous studies showed that serious games help promote people’s health. However, the potential for serious games to be used for successful cancer control for children and adolescents has received less attention.

Objective
This scoping review aimed to map the use of serious games in cancer prevention and cancer care for children and adolescents, and provide future directions for serious games’ development and implementation within the context of cancer control for children and adolescents.

Methods
This study followed a combination of the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) and the JBI (Joanna Briggs Institute) framework for the conduct of scoping reviews. PubMed, CINAHL Plus Full Text, Scopus, Web of Science Core Collection, and American Psychological Association (APA) PsycINFO databases were used for the search.

Results
From the initial 2750 search results, 63 papers were included in the review, with 28 quantitative, 14 qualitative, and 21 mixed method studies. Most of the studies were cancer care serious game papers (55/63, 87%) and a small number of studies were cancer prevention serious game papers (8/63, 13%). The majority of the included studies were published between 2019 and 2023 (cancer prevention: 5/8, 63%; cancer care: 35/55, 64%). The majority of the studies were conducted in Europe (cancer prevention: 3/8, 38%; cancer care: 24/55, 44%) and North America (cancer prevention: 4/8, 50%; cancer care: 17/55, 31%). Adolescents were the most represented age group in the studies’ participants (cancer prevention: 8/8, 100%; cancer care: 46/55, 84%). All (8/8, 100%) cancer prevention serious game papers included healthy people as participants, and 45 out of 55 (82%) cancer care serious game papers included patients with cancer. The majority of cancer prevention serious game papers addressed game preference as a target outcome (4/8, 50%). The majority of cancer care serious game papers addressed symptom management as a target outcome (28/55, 51%). Of the cancer care studies examining serious games for symptom management, the majority of the studies were conducted to treat psychological (13/55, 24%) and physical symptoms (10/55, 18%).

Conclusions
This review shows both the growth of interest in the use of serious games for cancer control among children and adolescents and the potential for bias in the relevant literature. The diverse characteristics of the included papers suggest that serious games can be used in various ways for cancer control among children and adolescents while highlighting the need to develop and implement serious games in underrepresented areas.
Interspecies pregnancy between Ovis canadensis mexicana and Ovis aries with reduced placental P450scc expression and intrauterine growth restriction
Authors: García Araceli Chávez , Cabrera-Reyes Erika Alejandra , Molina-Salinas Gladys , Olvera-Sánchez Sofía , Mejía-Villanueva Octavio , Martínez Federico , Cerbón Marco 
Published: May 2024

The present study aimed to assess the steroidogenic process in the placenta of hybrids Ovis canadensis mexicana × Ovis aries, particularly, to determine the plasma lipid profile and the relative abundance of proteins related to the steroidogenesis, to elucidate in part the mechanism of progesterone deficiency in hybrids. Plasma lipoproteins and placental cholesterol were determined by dry chemical colorimetric assays. Steroidogenic acute regulatory protein (STARD1), StAR-related lipid transfer domain protein 3 (STARD3), cholesterol side-chain cleavage enzyme (P450ssc), and 3β-hydroxysteroid dehydrogenase (3β-HSD) were evaluated by Western blot. In addition, STARD3 was also investigated by immunohistochemical experiments in sheep placenta. Results indicated that cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very low-density lipoprotein (VLDL) plasma levels were similar between hybrid and control pregnancy groups. Conversely, intracellular cholesterol was increased (P ˂ 0.05) in the placenta tissue of hybrids. No significant differences in the relative abundance of both STARD3, STARD1, and 3β-HSD enzyme were observed in the placenta of hybrids compared to control animals, while the relative abundance of cytochrome P450scc was lower in hybrids than in control animals (P = 0.0279). The presence of STARD3 was observed in the cytoplasmic and perinuclear regions of mononucleate and binucleate cells of the trophoblast in the sheep placenta. The significant decrease in the abundance of P450scc in hybrids’ placenta may explain the decrease in progesterone biosynthesis, which has been related to intrauterine growth restriction (IUGR) in these animals previously.
The Effect of Noise and Light on Sedation in Critical Care Patients. A Cross-Sectional Study of Critical Care Nurses in Three Intensive Care Units in Norway
Authors: Nystrøm Vivian , Fosser Olsen Brita 
Published: May 2024

Background: International guidelines for pain, sedation, delirium, immobility, and sleep in critically ill patients recommend the use of noise and light reduction strategies to improve sleep. The aims of this study were: 1) to evaluate critical care nurses’ (CCNs) perceptions regarding sources of noise and light in the intensive care unit (ICU), and 2) to identify factors associated with critical care patients’ need for sedation when their sleep is disturbed by noise or light.
Methods: A cross-sectional study was conducted in three Norwegian ICUs (n = 193).
Results: A total of 87% of the CCNs stated that critical care patients were exposed to noise, and the most frequent sources were alarms from monitoring equipment (71%) and mechanical ventilators (70%), and nurses talking (65%). The results demonstrated higher odds for critical care patients needing sedation when sleep was disturbed by noise, if the CCNs reported that noise disturbed patients sleep (OR 3.05), and lower odds if the CCN was from ICU C (OR 0.39). Most CCNs (82%) answered that there was a difference in the level of light during day versus night, and that the most frequent source of light at night was from small lamps (46%). It was higher odds that the CCNs perceived that critical care patients needed sedation when sleep was disturbed by light if the light disturbed the patient’s sleep in the unit (OR 4.78). There were lower odds if the CCNs was from ICU A (OR 0.32) or ICU C (OR 0.34).
Conclusion: The findings from this study indicate that CCNs use sedatives to induce sleep for critical care patients to compensate for environmental factors such as noise and light. Variations between ICUs indicate different sedation practices between Norwegian ICUs.
KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA DITINJAU DARI MOTIVASI BERPRESTASI PESERTA DIDIK SMA
Authors: Nilawati  , Nursupiamin  , Badjeber Rafiq 
Published: May 2024

Tujuan penelitian ini adalah untuk mengetahui bagaimana kemampuan pemecahan masalah matematika ditinjau dari motivasi berprestasi peserta didik SMA.Penelitian ini menggunakan metode Kualitatif dengan menggunakan pendekatan deskriptif. Subjek dalam penelitian ini yaitu peserta didik kelas XI IPA SMA Negeri 1 Sindue Tombusabora. Subjek penelitian ini berjumlah 25 peserta didik, kemudian diambil 3 subjek untuk mewakili masing-masing kategorisasi tinggi, sedang dan rendah untuk dianalisis kesulitan dalam menyelesaiakan soal pemecahan masalah matematika. Instrument pada penelitian ini menggunakan angket, tes kemampuan pemecahan masalah mateatika dan pedoman wawancara. Analisis data pada penelitian ini adalah penyajian data, reduksi data, dan kesimpulan.Hasil penelitian ini menunjukkan bahwa Peserta didik yang memiliki Motivasi Berprestasi Tinggi (MBT) mampu memenuhi 4 indikator pemecahan masalah matematika yaitu, memahami masalah, menentukan rencana penyelesaian masalah, melaksanakan rencana penyelesaian masalah dan memeriksa kembali. Sedangkan peserta didik dengan Motivasi Berprestasi Sedang (MBS) mampu memenuhi 4 indikator yaitu memahami masalah, menentukan rencana penyelesaian masalah, melaksanakan rencana penyelesaian masalah dan memeriksa kembali, dan pada Subjek dengan Motivasi Berprestasi Rendah (MBR) mampu memenuhi 1 indikator pemecahan masalah yaitu memahami masalah.
Projeto lei n. 6.299/2002 “Lei Pacote Veneno” e a ofensa ao princípio da proibição do retrocesso ambiental
Authors: Steidel Milena , Guerber Patricia Minini Wechinewsky 
Published: May 2024

O uso desenfreado de agrotóxicos traz inúmeras consequências tanto para o meio ambiente quanto para a saúde e qualidade de vida da população. Com isso, busca-se apresentar neste artigo discussão em relação ao projeto de Lei 6.299 de 2002 que visa flexibilizar o registro e utilização de agrotóxicos no país. O problema de pesquisa questiona se pode-se vislumbrar retrocesso ambiental no projeto de Lei 6.299/2002. Como objetivo geral busca-se analisar se o projeto de Lei 6.299/2002 contém pontos que possam caracterizar o retrocesso ambiental. A hipótese de pesquisa aventada é de que o retrocesso ambiental será concretizado se o referido projeto for transformado em lei. Trata-se de pesquisa exploratória e bibliográfica com consulta à doutrina especializada. O método utilizado é o hipotético-dedutivo consistindo na construção de premissas baseadas na hipótese aventada. Em resposta ao problema de pesquisa, constatou-se que a hipótese aventada restou confirmada visto que o retrocesso ambiental fica evidenciado sendo demonstrado o grande impacto ambiental que será concretizado caso o projeto de Lei 6.299/2002 seja aprovado, implementando a retirada do poder de duas das agências regulamentares de agrotóxicos no Brasil, sendo estas a Agência Nacional de Vigilância Sanitária (Anvisa) e do Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais (Ibama), flexibilizando no país ainda mais o uso de tóxicos em plantações, trazendo consequências irreparáveis na saúde e meio ambiente afastando ainda mais uma realidade em que se tenta introduzir o desenvolvimento sustentável.
Mitral regurgitation carries greater prognostic significance than mitral stenosis in patients undergoing transcatheter aortic valve replacement
Authors: Polizzi Giovanni , Campos Karla , Coulter Stephanie Alyse 
Published: May 2024

Aims
This study assessed the outcomes of concomitant mitral valve disease and severe aortic stenosis in patients undergoing transcatheter aortic valve replacement (TAVR).

Methods
Echocardiographic data of 813 patients with severe aortic stenosis undergoing transfemoral TAVR were collected, and clinical outcomes were analyzed for individuals with mitral stenosis and mitral regurgitation.

Results
The final cohort includes 788 patients with severe calcific aortic stenosis. Among single parameters of mitral stenosis, a smaller baseline mitral valve area (MVA) by the continuity equation and higher postprocedural mean mitral gradients (MMG) were associated with an increased risk of death at 1 year (P-values 0.02 and <0.01, respectively), but no correlation with outcomes was demonstrated after multivariate adjustment for major prognosticators. Mitral stenosis (based on MVA + MMG) was not associated with complications or mortality. Mitral regurgitation was present in 94.6% of the population at baseline and regressed by at least one grade post-TAVR in 28% of the patients. The improvement in mitral regurgitation was associated with a greater prosthetic effective orifice area (P-value 0.03). Significant (at least moderate) residual mitral regurgitation was correlated with short-term complications and shown to be an independent predictor of 1-year mortality (P-value 0.02, odds ratio (OR) 5.37, confidence interval 1.34–21.5).

Conclusion
Mitral regurgitation has a greater impact on TAVR patients than mitral stenosis as assessed by functional methods.
Tourism Competitiveness and Mobile Data: A Grey Relational Analysis for European Entrepreneurship Pre & During Pandemic
Authors: Gabor Manuela Rozalia , Curta Petru Alexandru , Oltean Flavia Dana 
Published: May 2024

Abstract
The tourism country’s competitiveness is important especially when countries strive for bigger market shares as European countries are. The COVID-19 pandemic has had devastating effects on tourism and the entire tourism industry must be rethinking and reshaping given some opportunities and challenges to the entrepreneurs, local communities, local administrations, governments of competitiveness destinations. In this paper we measured if the Google and Apple mobility indices cand predict (or not) the movement of TTCI during pandemic compared with pre-pandemic TTCI ranks by using grey system theory and statistical methods. The aim of the paper is to validate the Grey Relational Analysis (GRA) as identifier of the good predictor (statistically significant for p-value< 0.05) for European tourism competitiveness (measured by TTCI) in particular conditions, especially before and during COVID-19 pandemic time by take into consideration the Google Mobility and Apple Mobility data and their relationship with overnight stays for 11 European countries. To validate the GRA as method for good and accurate predictor for tourism competitiveness for TTCI 2021 (during COVID-19 pandemic time) a GLM – General Linear Model ANOVA with interaction effects and Tukey HSD Post Hoc Multiple Comparisons was applied. Our results validated the powerful of GRA for tourism competitiveness, statistically significant according to GLM with interaction effects, and emphasis (especially for entrepreneurs) that the overnight stays will give the right rank on top of tourism competitiveness, prior to other ITC support as Google and Apple Mobility indices proved by reflection of overnights on TTCI 2021 – during pandemic.
English Financial Aid for the Reformed College of Debrecen in Light of Hungarian Archival Sources
Authors: Bozzay Réka 
Published: May 2024

Abstract
At the end of the seventeenth century, following the retreat of the Ottoman Empire from the region, the whole of the Kingdom of Hungary came under the jurisdiction of the Catholic Habsburgs, who introduced a number of measures that restricted the rights of Protestants. One of these measures affected the city ministers and the professors of the Reformed College in Debrecen, when they were forbidden by the Chamber of Szepes to have their salaries financed by the city. In such a situation, the leaders of the college had to seek financial help from Protestant-friendly countries such as Switzerland, the Netherlands, and England. Drawing on primary sources available in the Archives of the Reformed Church District of Tiszántúl, the aim of this paper is to present the history of the financial aid the Reformed College received mainly from England (and to some extent Ireland and Scotland) from the seventeenth century to the end of the twentieth century with a focus on how the money was collected and how it was transferred to Hungary. (RB)
Open Wounds and Physical Divisions: Pre-Brexit Visions of a Divided Kingdom
Authors: Funk Wolfgang 
Published: May 2024

Abstract
This article frames Brexit as the consequence of social and demographic fissures running through the United Kingdom, thereby arguing that Britain’s exit from the European Union is symptomatic of a specifically English rather than British crisis of national identification. It shows how such internal faultlines within the UK’s society intersect with the evocation and employment of various kinds of border imagery and border discourses in the run-up to the Brexit Referendum in 2016. For the main part of the analysis, the article sets out to broaden the by now well-established genre of “BrexLit” (Shaw, Everitt) by focusing on what could be called “Pre-BrexLit,” that is, novels written well before Brexit became a term, let alone political reality. By way of three exemplary texts—Julian Barnes’s England, England (1998), Tony Saint’s Refusal Shoes (2003), and Rupert Thomson’s Divided Kingdom (2005)—the analysis retraces how literary accounts of how to establish, maintain and control borders—both real and metaphorical, mental and physical, external and internal—prefigure some of the divisive issues around which the Brexit struggle would revolve, while at the same time avoiding the necessarily contentious and biased labels attached to post-fact Brexit literature. (WF)
Incidence of Student Participation in The Democratic Culture of School Municipalities
Authors: Gamio Lourdes Candelaria Moreno , Cueva Martha Alexandra Padilla , Carranza Julio Enrique Haro , Fernández José Roberto Barrionuevo , Gamio Analucia del Rosario Moreno , Azahuanche Manuel Angel Pérez 
Published: May 2024

Purpose: Determine to what extent student participation affects the democratic culture of School Municipalities.

Theoretical Framework: Focuses on the importance of developing a democratic culture through student participation in spaces such as school municipalities, based on the theories of John Dewey and Roger Hart.

Method: A quantitative approach was used with a causal correlational design and a sample of 230 students between 12 and 17 years old, selected from a population of 569 members of the school municipalities through probabilistic sampling.

Results and Discussion: It was found that 32.6% of students consider student participation positive, while 33.9% perceive it negatively. Furthermore, 68.3% report a regular perception of the democratic culture in school municipalities. Although there are spaces for participation, student involvement remains low on many occasions.

Research Implications: This study seeks to promote democratic culture through student participation in school, thus contributing to improving educational management and aligning with the objectives of sustainable development in education.

Originality: Offers a perspective on the role of educational institutions in building a democratic school community through student participation.

Conclusion: Student participation has a significant impact (82.5%) on the democratic culture of the School Municipalities, which supports the study hypothesis. It is crucial that students understand their role as citizens and actively participate in school life to build a strong democratic culture.
Relationship of Self-Efficacy to The Knowledge of Women of Childbearing Age in Early Detection of Cervical Cancer
Authors: Utami Sri , Yunitasari Esti , Triharini Mira , Nursalam  , Kurniawati Ninuk Dian , Efendi Ferry , Nihayati Hanik Endang 
Published: May 2024

Introduction: Cervical cancer, is well known in the world, and this disease is a malignant disease that attacks the reproductive organs of a woman that can no longer be tolerated and about which all women should be aware. Therefore, female self-efficacy is crucial for women of childbearing age to advance knowledge and particularly maximize the reproductive health of these women.

Aim: Search for data and results from this study, the author wants to determine the significance and the possible correlation between the effectiveness of women of childbearing age and their knowledge of the performance of cervical cancer screening using the VIA method, so that cervical cancer will not be affected.

Method: In this quantitative study, researchers used a correlational descriptive design where the approach used was cross-sectional. In this study, researchers used a sample of 97 respondents in the consultation area of the Harapan Raya Community Health Center in Riau Pekanbaru Province. Sampling is carried out by researchers with the greatest care, following predetermined inclusion criteria and using targeted sampling techniques. Likewise, data analysis is carried out using the chi-square test method.

Results: Demographic data from this study indicate that 53.6% of respondents were young adults. The majority of 43.3% of respondents have a college degree and the highest data, mothers are only housewives, accounting for 82.5% of respondents. Through the process of univariate analysis, it was determined that a majority of respondents, specifically 62.9%, had a significantly low level of self-efficacy. Furthermore, it was found that 55.7% of the respondents had a sufficient level of knowledge. The use of the chi-square test in data analysis revealed a notable association between self-efficacy and knowledge of women of childbearing age regarding cervical cancer screening using the VIA method, which is inexpensive, effective, and immediate results are known. This association was supported by a p-value of 0.002, indicating statistical significance.
Conclusion: Based on the research results, it was found by researchers that there is a remarkable correlation between self-efficacy and the level of knowledge of women of childbearing age regarding cervical cancer screening using the VIA method, which is a good result to recommend.

Recommendation: Researchers recommend that this study be used as a method to increase self-efficacy and knowledge of women of childbearing age in cervical cancer screening using the VIA method.
THE INFLUENCE OF INNOVATIVE BEHAVIOR AND REWARD SYSTEM ON EMPLOYEE PERFORMANCE WITH CREATIVE THINKING ABILITY AS A MODERATOR
Authors: Liman Ineh , Santamoko Ruby , Limajatini Limajatini , Anggraeni Dian 
Published: May 2024

In the effort to develop a company, having a strong human resource base is crucial. Good employee performance is the primary asset that can execute and influence various operational aspects of the company. Companies should be able to foster employee potential by encouraging innovative thinking and providing rewards to motivate them to improve their performance. This research aims to analyze the influence of innovative behavior, reward systems, and creative thinking ability on employee performance. The study employs a survey method with a quantitative approach, collecting data from 142 respondents who are employees of an organization. Data analysis was conducted using Smart PLS 3, and Hair's method was used to determine the sample size and respondent results. The research findings indicate that innovative behavior and the reward system positively affect employee performance. Creative thinking ability acts as a moderating variable that strengthens the impact of innovative behavior on employee performance. This research has significant implications for organizations, highlighting the need to enhance innovative behavior, reward systems, and creative thinking to improve employee performance. In the corporate context, if a company aims to boost employee performance, it should enhance innovative behavior and reward systems with the moderation of creative thinking ability.