bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perception of quality of life in school-age children born before 32 weeks of gestational age
Authors: Merino-Hernández Amaia , Muñoz-Cutillas Agustin , Ramos-Navarro Cristina , Bellón-Alonso Sara , Rodríguez-Cimadevilla Juan Luis , González-Pacheco Noelia , Sánchez-Luna Manuel 
Published: June 2024

Abstract

Background: Preterm infants with bronchopulmonary dysplasia (BPD) are at increased risk of disruptions in their quality of life (QoL) at school age, often associated with respiratory morbidity and the need for ongoing hospital care.
Objective: To assess the impact of BPD on perceived quality of life in preterm infants at school age.
Methods: We conducted a prospective observational study of infants less than 32 weeks' gestation admitted to our neonatal unit between January 2012 and December 2014. Quality of life was assessed at school age using the Pediatric Quality of Life (PedsQL) questionnaire, with higher scores indicating poorer quality of life.
Results: The study included 102 patients with a mean gestational age of 29.42 weeks (SD 1.87) and a mean birth weight of 1221.36 g (SD 347.25), with an average age of 8.59 years (SD 0.90) at the time of the survey. Patients with BPD 2-3 exhibited a significantly poorer perception of “total quality of life” (p=0.03) and in the “social activities” domain (p=0.02) compared to those without BPD or with BPD 1; even after adjusting for gestational age in a multivariate model. No significant differences were observed for “health & activities” domain (p=0.31), “emotional state” domain (p=0.58), or “school activities” domain (p=0.33). No significant differences were found between patients without a diagnosis of BPD and those with grade 1 BPD. Similarly, no significant differences were observed when comparing patients of less than 28 weeks' gestational age and more than 28 weeks of gestational age.
Conclusion: In our study of preterm infants, those diagnosed with grade 2-3 BPD exhibited lower perceived quality of life compared to preterm infants without BPD or with grade 1 BPD. No differences in quality of life were observed between patients without BPD diagnosis and those with grade 1 BPD. No significant differences in QoL were found between infants born before and after 28 weeks' gestation.
Could the presence of ferrihydrite identified in a riverbed impacted by mining leachates be linked to the reduction in the Heavy Metals Contamination Index?
Authors: Morales-Mendoza Asunción Guadalupe , Flores-Trujillo Ana Karen Ivanna , Razo-Jiménez Luz María Del , Peña-Ocaña Betsy Anaid , Missirlis Fanis , Rodríguez-Vázquez Refugio 
Published: June 2024

Abstract

Water bodies have suffered degradation due to the discharge of pollutants, including potentially toxic elements (PTEs), primarily from mining operations. One such instance is the extraction of metallic elements in Taxco de Alarcón, Mexico. In this study, elements were analysed by Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) in 11 points of Acamixtla, Taxco, and San Juan Rivers. The data analysis included principal components analysis (PCA) and determination of Heavy-Metals and Metalloids Pollution Index (HMPI), as well as their Health Risk Assessment. Additionally, solid samples from RSJMG S2.3 were characterized by Fourier Transform-Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). The elements (As, Cr, Ni, Zn, Fe, Mn, Cu, Cd, Pb, Se, and Li) were identified in the water samples. PCA revealed that component one, accounted for 82.8% of the variability data, and Pearson correlation analysis showed a significant (p < 0.05) correlation of Fe with As, Cu, Pb, and Zn. The highest HMPI (8491.52) was detected at RSJMG S2.3 point. Other points exhibited a 96.45 % to 100% lower exposure than RSJMG S2.3 point, that could be due to metal complexation with naturally occurring mineral ferrihydrite (Fe10 O14(OH)2), that was identified by SEM and FTIR in solids collected at the RSJMG S2.3 point. For Health Risk Assessment, the chronic oral daily intake and dermal exposure were predominant in all points impacted by leachates downstream of the San Juan River. Likewise, for the elements Cd, As and Zn were highest values and all sites presented high hazard index.
Apoptotic vesicles rescue impaired mesenchymal stem cells and their therapeutic capacity for osteoporosis by restoring miR-145a-5p deficiency
Authors: Zhang Rong , Mu Xiaodan , Liu Dawei , Chen Chider , Meng Bowen , Qu Yan , Liu Jin , Wang Runci , Li Chuanjie , Mao Xueli , Wang Qintao , Zhang Qingbin 
Published: June 2024

Abstract

Apoptotic vesicles (apoVs) play a vital role in various pathological conditions; however, we have yet to fully understand their precise biological effects in rescuing impaired mesenchymal stem cells (MSCs) and regulating tissue homeostasis. Here, we proved that systemic infusion of bone marrow MSCs derived from wild-type (WT) mice effectively improved the osteopenia phenotype and hyperimmune state in ovariectomized (OVX) mice. Importantly, the WT MSCs rescued the impairment of OVX MSCs both in vivo and in vitro, whereas OVX MSCs did not show the same efficacy. Interestingly, treatment with apoVs derived from WT MSCs (WT apoVs) restored the impaired biological function of OVX MSCs and their ability to improve osteoporosis. This effect was not observed with OVX MSCs-derived apoVs (OVX apoVs) treatment. Mechanistically, the reduced miR-145a-5p expression hindered the osteogenic differentiation and immunomodulatory capacity of OVX MSCs by affecting the TGF-β/Smad 2/3-Wnt/β-catenin signaling axis, resulting in the development of osteoporosis. WT apoVs directly transferred miR-145a-5p to OVX MSCs, which were then reused to restore their impaired biological functions. Conversely, treatment with OVX apoVs did not produce significant effects due to their limited expression of miR-145a-5p. Overall, our findings unveil the remarkable potential of apoVs in rescuing the biological function and therapeutic capability of MSCs derived from individuals with diseases. This discovery offers a new avenue for exploring apoVs-based MSC engineering and expands the application scope of stem cell therapy, contributing to the maintenance of bone homeostasis through a previously unrecognized mechanism.
The psychoeducational interventions: a valuable communication tool to support the caregiver of people with dementia
Authors: Cintoli Simona , Tommasini Luca , Prete Eleonora Del , Cerri Matilde , Ceravolo Roberto , Tognoni Gloria 
Published: June 2024

Abstract

Background
informal caregivers of people with dementia are at greater risk of developing physical and mental health problems when compared to the general population: they often experience high levels of stress which can lead to a lowered sense of well-being, feelings of being burdened, depression and compromised physical health. The significant beneficial effects of Psychoeducational Interventions on the critical outcomes of caregiver burden and strain were considered sufficient to warrant a recommendation in favour of the intervention. The emergence of the COVID-19 pandemic has significantly increased the use internet-based interventions: this study describes the effectiveness of support program for informal caregivers of people with dementia internet-based and on-site conditions.
Methods
A Psychoeducational Interventions program, consisting of 5 meetings every 2 weeks, has been structured. It aims to provide information and strategies for managing cognitive and psycho-behavioral symptoms in neurodegenerative diseases, as well as to develop effective communication skills and understanding of the caregiver's experience. Intervention formats include slides, video, group discussions and are always led by a psychologist. We assessed in 73 caregivers (33 internet-based and 40 on-site conditions) level of Behavioural and Psychological Symptoms of Dementia management, dementia awareness, social support, find leisure time, harmony with relative, stress, with Visual-Analogue Scale at the beginning of PI and at the end. During the pandemic period the protocol was adapted to be available online and subsequently proposed to caregivers belonging to the Cognitive Disorders and Dementia Centre.
Results
in both modalities, internet-based and on-site condition, a statistically significant improvement was highlighted in all aspects (p < 0.05, for all p-value). Questionnaire on basic dementia knowledge was successfully completed at 100%. Also, participants reported a medium to high level of satisfaction with very limited dropouts (< 3%).
Conclusions
The evidence from this pilot study indicated that caregiver support interventions in both conditions significantly improved several and important outcomes: they showed a significant effect in reducing caregiver strain and improving ability and knowledge. Indeed, Psychoeducational Interventions contribute to effective coping strategies to mitigate caregiver burden so they can continue to provide care for loved ones.
Circulating pre- and postprandial extracellular vesicle proteomic profiles
Authors: Garza Alejandra P. , Wider-Eberspächer Elisa , Morton Lorena , Ham Marco van , Pállinger Éva , Buzás Edit I. , Jänsch Lothar , Dunay Ildiko Rita 
Published: June 2024

Abstract

Extracellular vesicles (EVs) are key in intercellular communication, carrying biomolecules like nucleic acids, lipids, and proteins. This study investigated postprandial characteristics and proteomic profiles of circulating large extracellular vesicles (lEVs) in healthy individuals. Twelve participants fasted overnight before baseline assessments. After consuming a controlled isocaloric meal, lEVs were isolated for proteomic and flow cytometric analysis. Plasma triacylglyceride (TAG) levels confirmed fasting completion, while protein concentrations in plasma and lEVs were monitored for postprandial stability. Proteomic analysis identified upregulated proteins related to transport mechanisms and epithelial/endothelial functions postprandially, indicating potential roles in physiological responses to nutritional intake. Enrichment analyses revealed vesicle-related pathways and immune system processes. Flow cytometry showed increased expression of CD324 on medium-sized CD9+CD63+CD81+ EVs postprandially, suggesting an epithelial origin. These findings offer insights into postprandial lEV dynamics and their physiological significance, highlighting the need for stringent fasting guidelines in EV studies to account for postprandial effects on EV composition and function.
Introduction of nirsevimab in Catalonia, Spain: description of bronchiolitis and the Respiratory Syncytial Virus incidence in the 2023/24 season
Authors: Perramon-Malavez Aida , de Rioja Victor López , Coma Ermengol , Hermosilla Eduardo , Fina Francesc , Martínez Montserrat , Mendioroz Jacobo , Cabezas Carmen , Montañola-Sales Cristina , Prats Clara , Soriano-Arandes Antoni 
Published: June 2024

Abstract

Purpose
Respiratory Syncytial Virus (RSV) causes most of the bronchiolitis and thousands of deaths annually, particularly in infants less than 6 months. In Catalonia (Spain), infants born between April 2023 and March 2024 aged 0–6 months during their first RSV season have been candidates to receive nirsevimab, the novel monoclonal antibody against RSV, since October 2023. We aimed to analyse the dynamics of all-causes bronchiolitis diagnoses and RSV community infections in the current season and compare them to pre-nirsevimab epidemics.
Methods
We collected epidemiological data from the Information System for Surveillance of Infections (SIVIC) in Catalonia on daily all-causes bronchiolitis clinical diagnoses and RSV-confirmed cases provided by rapid antigen tests in Primary Care Practices. We calculated the rate ratio (RR) for the incidence of all-causes bronchiolitis for children aged 0-11m-old concerning 12-35m-old between September 2014 and January 2024. We analysed the RR of the incidence of RSV-confirmed infection for 0-11m-old and 12-35m-old concerning the > 35m-old, from January 2021 to January 2024. We then computed the relative difference of the RR, named percentage of reduction of risk, between season 2023/24 and former epidemics.
Results
With a global coverage rate for nirsevimab of 82.2% in January 2024, the age-specific 0-11m-old RR (95%CI) of RSV infection incidence regarding > 35m-old was 1.7 (1.5-2.0) in last season 2023/24. The RR (95%CI) had been 7.4 (5.6–9.9), 8.8 (6.9–11.3), and 7.1 (5.7–8.9) in 2020/21, 2021/22 and 2022/23 seasons. Regarding the incidence of all-causes bronchiolitis for 0-11m-old group compared to the 12-35m-old, the pre-pandemic (2014/15-2019/20) and 2022/23 RR (95%CI) were 9.4 (9.2–9.6) and 6.0 (5.7–6.2) respectively, significantly higher than the RR of 3.6 (3.4–3.8) for the last season 2023/24.
Conclusions
Coinciding with the introduction of nirsevimab, the risk of RSV infection for infants aged 0-11m-old regarding > 35m-old has been reduced by 75.6% (73.4–77.5) from last season, and the risk for all-cause bronchiolitis regarding 12-35m-old by 61.9% (60.9–62.9) from the pre-pandemic period and by 39.8% (39.3–40.2) from 2022/23 epidemic, despite a high RSV community transmission, especially in older infants.
The Impact of Childhood Psychological Abuse on Internet Altruistic Behavior: The Chain Mediating Role of Dark Triad and Negative Cognitive Emotional Regulation
Authors: Zheng Xianliang , Song Zijia , Zhou Xiangsen , Xie Jiawen 
Published: June 2024

Abstract

Under the Chinese culture of filial piety, parents have absolute authority, and many of their behaviors are actually psychological abuse of their children, but the parents themselves are not aware of it. A questionnaire survey was conducted on 567 Chinese college students (Mage = 19.56, SD = 0.49, 40.21% males) to explore the relationship between childhood psychological abuse (CPA) and Internet altruistic behavior (IAB), as well as the role of dark triad and negative cognitive emotion regulation (NCER). Results indicated that: (1) There was a significant negative correlation between CPA and IAB; (2) NCER played a partially mediating role between CPA and IAB, whereas the mediating role of dark triad between CPA and IAB was insignificant; (3) Dark triad and NCER played a chain mediating role between CPA and IAB. The present study provides a new perspective on IAB from the perspective of family functioning and positive psychological interventions.
All Together Now: Activity Synchrony and Social Cohesion in Group-Living Animals
Authors: Schaposnik Laura P. , Hsu Sheryl , Dunbar Robin I.M. 
Published: June 2024

Abstract

A central problem all group-living animals face is how to maintain group cohesion during the course of the day in the face of forces that drive animals apart. When activity schedules become desynchronised, groups will inevitably fragment as animals drift apart. To explore the impact that individual differences in activity scheduling might have for group cohesion, we here explore the consequences having different activity schedules has for social cohesion. By modeling a group as a set of semi-coupled oscillators, we show that, all else equal, the members of the group will become less and less coupled across the active day until the group devolves and breaks apart, setting an upper limit on the size of group that can be maintained as a coherent entity given a particular level of correlation in members' activity schedules. We then show that when social bonding creates a stickiness, or gravitational pull, between pairs of individuals, fragmentation is reduced. We argue that large, stable social groups are only possible when some form of social bonding has evolved.
Students’ Self-Efficacy in Senior Secondary School Mathematics: Academic Engagement as Predictor Variable
Authors: Asanre Akorede Ayoola , Chinaka T. W 
Published: June 2024

Abstract

Students who lack confidence believe that they cannot accomplish a work, view the activity as pointless, and as a consequence, don't want to put any time or effort into it but when properly engage brings about traits that are needed in a student, hence academic engagement is seen as a potential antidote to the issue of students’ self-efficacy in mathematics. Therefore, this paper investigated student’s self-efficacy in senior secondary school mathematics as being predicted using academic engagement. Ex-post facto correlational research design was used. 1680 students from Senior Secondary School II made up the study's sample from the twenty-one randomly selected schools in the three Local Government Areas of Remo division of Ogun State. Mathematics Student Academic Engagement Scale (MSAES) with and Mathematics Self Efficacy Scale (MSES) with . Findings showed that cognitive engagement significantly predicts self-efficacy of students in Mathematics (F = 527.320, p<0.05). Also, behavioural engagement significantly contributes to the variance in students’ self-efficacy in Mathematics (F = 759.251, p<0.05). Further more emotional engagement significantly contributes to the variance in students’ self-efficacy in Mathematics (F = 667.409, p<0.05). Result also revealed that the predictor variables cognitive, behavioural and emotional engagement when taken together significantly contribute to the variance in students’ self-efficacy in Mathematics (F = 380.151, p<0.05). This study concluded that cognitive, emotional and behavioural engagements are good predictors of senior secondary school students’ mathematics self-efficacy. To increase students' self-efficacy in mathematics, stakeholders in Nigerian education are advised to ensure that students are engaged cognitively, emotionally, and behaviourally.
Barriers, and predictors of seeking mental health care among adults in Oman,2023: Across sectional study
Authors: Badi Moza Al , Aamri Sumaiya Al , Dhuhli Khalid Al , Alghafri Asaad , Elsayed Eman 
Published: June 2024

Abstract

Mental Health problems are causing disability among adults globally. They can be managed and controlled effectively if patients seek help early. Therefore, studying help-seeking attitudes and barriers is essential to improve mental health in public. This study aims to determine help-seeking predictors and barriers and their associated factors that affect access to mental health services. It is a cross-sectional study, that involved willing Omani adults aged 18- 64 years old from the 18 primary health centers of Al Dahera governorate from August to September 2023. Data was collected using the Barriers to Access to Care Evaluation (BACE-III) questionnaire. The total participants were 357. It has been found that major stigma and attitudinal barriers were 42.9% and 41.5%, respectively. Participants with current mental health problems responded with 64% major stigma barriers and 69% major attitudinal barriers (P value= 0.001 & 0.023, respectively). The independent predictor for seeking mental health care was government workers (p-value = 0.014). In the Al Dahera governorate, seeking help attempts were found to be low. Stigma and attitudinal barriers affect seeking help significantly in the governorate. Increasing awareness to overcome these barriers will improve access to mental health services.
Comparing activation typicality and sparsity in a deep CNN to predict facial beauty
Authors: Tieo Sonia , Bardin Melvin , Bertin-Johannet Roland , Dibot Nicolas , Mendelson Tamra C. , Puech William , Renoult Julien P. 
Published: June 2024

Abstract

Processing fluency, which describes the subjective sensation of ease with which information is processed by the sensory systems and the brain, has become one of the most popular explanations of aesthetic appreciation and beauty. Two metrics have recently been proposed to model fluency: the sparsity of neuronal activation, characterizing the extent to which neurons in the brain are unequally activated by a stimulus, and the statistical typicality of activations, describing how well the encoding of a stimulus matches a reference representation of stimuli of the category to which it belongs. Using Convolutional Neural Networks (CNNs) as a model for the human visual system, this study compares the ability of these metrics to explain variation in facial attractiveness. Our findings show that the sparsity of neuronal activations is a more robust predictor of facial beauty than statistical typicality. Refining the reference representation to a single ethnicity or gender does not increase the explanatory power of statistical typicality. However, statistical typicality and sparsity predict facial beauty based on different layers of the CNNs, suggesting that they describe different neural mechanisms underlying fluency.
Investigation of the usability of black locust (Robinia pseudoacacia L.) cultivars for feed purpose in Hungary
Authors: LENGYEL-KÓNYA Éva , BERKI Mária , ZALÁN Zsolt , TAKÁCS Krisztina , SZERDAHELYI Emőke , TÖMÖSKÖZI-FARKAS Rita , ADÁNYI Nóra , BOROVICS Attila , RÁSÓ János , CSEKE Klára , MOLNÁR Tamás , KESERŰ Zsolt 
Published: June 2024

Abstract

Nowadays, one of the major challenges in the field of agricultural production is an increasing demand for protein in farm animal husbandry. The main source of protein today is still soybean meal, but there is an urgent need to involve alternative protein sources and assess areas of application. Leaf and fruit of black locust (Robinia pseudoacacia L.) could be a possible source of protein, therefore the main composition of different varieties was examined. Black locust is the most widespread tree species in Hungary occupying approximately 24% of the forested land (465,000 ha) and providing 25% of the annual timber output of the country. The mean wood volume of all black locust forests is 125 m3/ha, with a mean volume of 190 m3/ha at the final cutting age (31 years on average). Black locust foliage could be an important, complementary feed, as it plays the role of rumen filler and during grazing, animals can access other useful plants among the trees. Foliage samples were collected from individuals of black locust cultivars, and subsequent content analyses were carried out. With the help of satellite images, photosynthetic activity and health conditions were investigated in the experimental areas using vegetation and moisture indices on the basis of content values and digestibility studies.
HLA-G High-expressor 3’UTR Markers Are Linked to Gastric Cancer Development and Survival
Authors: Vaquero-Yuste Christian , Juarez Ignacio , Molina-Alejandre Marta , Molanes-López Elisa María , Gutiérrez-Calvo Alberto , López-García Adela , Lasa Inmaculada , Gómez Remedios , Arnaiz-Villena Antonio , Martin-Villa Jose Manuel 
Published: June 2024

Abstract

Gastric cancer ranks fifth in both world prevalence and lethality, with a 5-year survival of less than 30%. HLA-G, a non-classical class I HLA gene, has emerged as a potential marker for cancer susceptibility and prognosis due to its immunomodulatory properties. Its level of expression is regulated by polymorphisms in the 3’ untranslated region (3’UTR) polymorphisms, which form various combined haplotypes (UTR-1 to -9). In this study, we examined HLA-G 3’UTR polymorphisms in paired tissue samples from 111 patients with gastric adenocarcinoma and 119 healthy controls. Polymorphism analysis was performed using PCR and Sanger sequencing, followed by statistical analysis using SNPStats software. Survival analysis was conducted using Kaplan-Meier curves and multivariate Cox regression models. High-expressor HLA-G 3’UTR haplotypes (UTR-1 and UTR-6) were significantly associated with gastric cancer susceptibility, indicating a potential role in tumor immune evasion. Additionally, the 14 base pair insertion/deletion polymorphism (14bp I/D) emerged as a prognostic marker, with D/D genotype carriers showing lower survival rates compared to I/D and I/I genotype carriers. Our study highlights the clinical relevance of HLA-G polymorphisms in gastric cancer, suggesting their potential as prognostic markers and therapeutic targets. Further elucidation of HLA-G-related pathways could lead to personalized treatment strategies and improved patient outcomes in gastric cancer.