bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synergistic effect of HLA class II loci and cytokine gene polymorphisms on the risk of gastric cancer in Japanese patients with Helicobacter pylori infection
Authors: Ando Takashi , Ishikawa Takeshi , Kato Haruki , Yoshida Norimasa , Naito Yuji , Kokura Satoshi , Yagi Nobuaki , Takagi Tomohisa , Handa Osamu , Kitawaki Jo , Nakamura Naoto , Hasegawa Goji , Fukui Michiaki , Imamoto Eiko , Nakamura Chie , Oyamada Hirokazu , Isozaki Yutaka , Matsumoto Naohito , Nagao Yasuyuki , Okita Mika , Nakajima Yoshihiro , Kurokawa Manabu , Nukina Masafumi , Ohta Mitsuhiro , Mizuno Shigeto , Ogata Masakazu , Obayashi Hiroshi , Park Hyohun , Kitagawa Yoshihiro , Nakano Koji , Yoshikawa Toshikazu 
Published: June 2009

AbstractIt has been reported that polymorphisms of human leukocyte antigen (HLA) genes and several cytokine genes are associated with an increased risk of developing gastric cancer (GC). However, the results of studies from different geographic regions, ethnic groups and study groups are inconsistent. The aim of this study was to evaluate the influence of H. pylori infection and host genetic factors on GC susceptibility in Japanese patients with GC. We analyzed genotypes for HLA class I and II, tumor necrosis factor α, interleukin (IL)‐1β, IL‐1 receptor, IL‐4, IL‐4Rα and IL‐10 in 330 H. pylori‐infected noncardia patients with GC and 190 H. pylori‐infected nonulcer dyspeptic controls. Haplotype analyses indicated that the frequencies of the HLA DRB1*0405 and DQB1*0401 alleles were increased in the patients with intestinal‐type GC when compared with controls (both DRB1*0405 and DQB1*0401: p = 0.015, OR = 1.57, 95% CI = 1.09–2.26), but the changes were not statistically significant after correction for multiple comparisons. None of the cytokine gene polymorphisms were associated with GC susceptibility, whether patients with GC were analyzed as a group according to the histological subtype. Of interest was the comparison of controls and patients with intestinal‐type GC. The frequency of an IL‐10‐592AA homozygote showing concomitant carriage of the HLA DRB1*0405‐DQB1*0401 haplotype was significantly higher in patients with intestinal‐type GC (χ2 = 6.369, p = 0.0116, pc = 0.0464, OR = 2.43, 95% CI = 1.21–4.48). Our results suggest that the HLA class II and IL‐10‐592A/C polymorphisms synergistically affect the susceptibility to GC development of H. pylori‐infected individuals in the Japanese population. © 2009 UICC
Serum cholesterol levels in relation to the incidence of cancer: The JPHC study cohorts
Authors: Iso Hiroyasu , Ikeda Ai , Inoue Manami , Sato Shinichi , Tsugane Shoichiro 
Published: June 2009

AbstractAn inverse association between serum total cholesterol and cancer mortality cast a controversy for cause or result of low cholesterol on cancer risk. Therefore, we examined a total of 33,368 Japanese men and women aged 40–69 years, who were free of prior diagnosis of cancer and cardiovascular disease, undertook serum total cholesterol measurement and completed a food frequency questionnaire between 1990 and 1994. They were followed to ascertain incident total and major sites of cancer until the end of 2004 to examine sex‐specific associations between cholesterol and cancer risk by incident time, stage and virus infection. After 412,714 person‐years of follow‐up, 2,728 incident cancers were documented. Serum total cholesterol levels were inversely associated with risk of total cancer in men, with strong inverse associations with stomach cancer in men and liver cancer in both sexes. After exclusion for first 3‐year incident cases and advanced cases with metastasis, the inverse association diminished for total and stomach cancers but remained for liver cancer. The multivariable hazard ratios (95% CI) for serum total cholesterol <4.14 mmol/l versus 4.65–5.16 mmol/l were 1.15(0.92–1.43); p‐trend across the overall cholesterol categories = 0.25 for total cancer and 1.18(0.79–1.75), p‐trend = 0.04 for stomach cancer and 5.12(1.65–15.9), p‐trend = 0.0011 for liver cancer in men, and 5.73(1.57–20.9), p‐trend = 0.0007 for liver cancer in women. The sustained excess risk of liver cancer associated with low cholesterol was observed regardless of hepatitis‐C‐virus infection and drinking habits. Although the inverse association for liver cancer remained to be examined further, our findings do not support that low serum total cholesterol levels increase risks of total cancer and other major sites. © 2009 UICC
The human 1‐8D gene (IFITM2) is a novel p53 independent pro‐apoptotic gene
Authors: Daniel‐Carmi Vered , Makovitzki‐Avraham Efrat , Reuven Eliran‐Moshe , Goldstein Ido , Zilkha Noga , Rotter Varda , Tzehoval Esther , Eisenbach Lea 
Published: June 2009

AbstractThe human 1‐8 interferon inducible gene family consists of at least 3 functional genes; 9‐27, 1‐8D and 1‐8U, which are all linked on an 18‐kb fragment of chromosome 11 and are highly homologous. It has recently been shown by us and others that the 1‐8D gene is overexpressed in colon carcinoma. Here, we show, by sequence comparison of the 1‐8D in pairs of tumor/normal colon tissues, the existence of 6 different alleles, containing single‐nucleotide polymorphisms with no mutations. Transformation assays revealed a possible role for the 1‐8D gene as a transformation inhibitor. Further, transient expression of the human 1‐8D gene in multiple mammalian cell lines showed accumulation of cells in the G1 phase followed by elevation in the subG1 phase. SubG1 elevation was confirmed as apoptosis by Annexin‐V binding assays and transferase‐mediated dUTP nick end labeling assays. Moreover, knock‐down of 1‐8D provided partial protection from Etoposide and UV‐induced apoptosis. The induction of apoptosis by 1‐8D is dependent on caspase activities but not on p53 expression. Although 1‐8D induces apoptosis independently of p53, p53 expression downregulates 1‐8D protein expression. Our data suggest a role for the 1‐8D gene as a novel pro‐apoptotic gene that will provide new insights into the regulated cellular pathways to death. © 2009 UICC
Structural study of the salivary glands of Anocentor nitens (Acari: Ixodidae) during the feeding cycle
Authors: da Silva Vanderlei C. , Pinheiro Nadja L. , Ribeiro Vinícius R. , de Carvalho Raimundo W. , Scherer Paulo O. , dos Santos Marco Antônio J. , dos Santos‐Mallet Jacenir Reis 
Published: June 2009

AbstractThe salivary glands of Anocentor nitens (Neumann,1897) occur in pairs and are located in the anterolateral region of the general cavity, with milky white color and approximately equal sizes. They consist of a secretory portion and an excretion duct. In some glandular acini, all the cells had a basophilic appearance they were stained by hematoxylin, whereas others presented cells with different staining affinities. In this work, we describe the variations observed in these glands during the feeding cycle of ticks [after feeding (0 h) and successively at 24, 48, 72, 96, 120, and 144 h]. The cells stained by hematoxylin were shown to be more reactive to Alcian blue, thus demonstrating the presence of acid glycosaminoglycans, whereas those stained using eosin presented weak or no reaction. A strong reaction was found by the use of the periodic acid‐Schiff (PAS) technique, thereby suggesting the presence of glycogen and/or glycoconjugates containing hexose, confirmed by using salivary amylase before PAS, with partial destaining of the slides. Continuing presence of residual staining in these cells suggests the presence of glycoconjugates containing hexose. Cells with nuclei of circular outline and few granules (of different sizes) were found in type II acini, 72 h after collection. Type I acini presented wide lumina and walls composed of larger numbers of cells of cubic to cylindrical shape. The pronounced degranulation shown in this study over the course of the feeding cycle was associated with the release of substances for oviposition. Microsc. Res. Tech., 2009. © 2009 Wiley‐Liss, Inc.
Self‐assembled monolayers of DNA on cysteamine modified Au(111) surface: Atomic force microscopy study
Authors: Song Yonghai , Lian Wenping , Zhao Sucai , Wang Li , Li Zhuang 
Published: June 2009

AbstractThe λ‐DNA molecules self‐assemble on cysteamine‐modified gold (111) surface to form flat‐lying self‐assembled monolayers (SAMs). The formation kinetics of such DNA SAMs is studied by atomic force microscopy (AFM). AFM results show that DNA molecules do not arrange themselves on cysteamine‐modified gold (111) surface into a well‐ordered monolayer. It is also found that the surface density of DNA monolayer does not increase as the DNA concentration increases. The high temperature of DNA solution and the immersing in ultrapure water produce some obvious DNA bundles. Whereas divalent cations in DNA solution result in the formation of more compact DNA films. The obtained information may be useful for practical application of the DNA films and further theoretical studies. Microsc. Res. Tech., 2009. © 2009 Wiley‐Liss, Inc.
Ionic liquid catalyzed expeditious synthesis of 2‐aryl‐2,3‐dihydroquinolin‐4(1H)‐ones and 2‐aryl‐2,3‐dihydro‐4H‐chromen‐4‐ones under microwave irradiation
Authors: Kumar Dalip , Patel Gautam , Kumar Anil , K. Roy Ram 
Published: June 2009

Abstract
magnified imageA facile and convenient synthesis of 2‐aryl‐2,3‐dihydroquinolin‐4(1H)‐one and 2‐aryl‐2,3‐dihydro‐4H‐chromen‐4‐one has been described using ionic liquid catalyzed intramolecular cyclization of the corresponding 2′‐aminochalcones and 2′‐hydroxychalcones, respectively. The rapid and fairly general protocol affords product in good yield. Ionic liquid, 1‐butyl‐3‐methylimidazolium tetrafluoroborate, was recovered and reused without loosing its efficiency. J. Heterocyclic Chem., (2009)
Contribution of the trifluoroacetyl group in the thermodynamics of antigen–antibody binding
Authors: Oda Masayuki , Saito Minoru , Tsumuraya Takeshi , Fujii Ikuo 
Published: June 2009

AbstractWe analyzed the binding of the 7C8 antibody to the chloramphenicol phosphonate antigens—one containing a trifluoroacetyl group (CP‐F) and the other containing an acetyl group (CP‐H)—by using isothermal titration calorimetry (ITC). The thermodynamic difference due to the substitution of F by H was evaluated using free energy calculations based on molecular dynamics (MD) simulations. We have previously shown that another antibody, namely, 6D9, binds more weakly to CP‐H than to CP‐F, mainly due to the different hydration free energies of the dissociated state and not due to the unfavorable hydrophobic interactions with the antibody in the bound state. Unlike in the binding of the trifluoroacetyl group with 6D9, in its binding with 7C8, it is exposed to the solvent, as seen in the crystal structure of the complex of 7C8 with CP‐F. The thermodynamic analysis performed in this study showed that the binding affinity of 7C8 for CP‐H is similar to that for CP‐F, but this binding to CP‐H is accompanied with less favorable enthalpy and more favorable entropy changes. The free energy calculations indicated that, upon the substitution of F by H, enthalpy and entropy changes in the associated and dissociated states were decreased, but the magnitude of enthalpy and entropy changes in the dissociated state was larger than that in the associated state. The differences in binding free energy, enthalpy, and entropy changes determined by the free energy calculations for the substitution of F by H are in good agreement with the experimental results. Copyright © 2009 John Wiley & Sons, Ltd.
Land‐ocean contrasts in lightning activity over the Indian region
Authors: Kandalgaonkar S. S. , Kulkarni J. R. , Tinmaker M. I. R. , Kulkarni M. K. 
Published: June 2009

AbstractLand‐ocean contrasts in the lightning activity over Indian land and two surrounding oceanic regions viz. Arabian Sea and Bay of Bengal have been studied. Satellite‐based lightning flash data for 5‐year (1998–2002) period have been used. The study revealed that lightning activity over Bay of Bengal was three times higher than that over Arabian Sea and 9.3 times lower than that over land. The bimodal distribution is seen over Arabian Sea (peaks in April and November), and land (peaks in May and September). A unimodal distribution is observed over Bay of Bengal with peak in May. The maximum activity over Bay of Bengal occurs more at northern latitudes (28–30°N) compared with Arabian Sea (12–14°N). The land–ocean contrast is dominated by monsoon season. Comparison of lightning activity in the El Nino (2002) and La Nina year (1998–2001) shows that the lightning activity is increased by nearly 18% over the land region and it maybe attributed to in the increase in surface air temperature during the warm phase of El Nino, land sea breeze circulations and difference in the continental and the oceanic convection. Copyright © 2009 Royal Meteorological Society
Effects of site change and urbanisation in the Beijing temperature series 1977–2006
Authors: Yan Zhongwei , Li Zhen , li Qingxiang , Jones Phil 
Published: June 2009

AbstractDuring 1977–1981 the Beijing (BJ) meteorological station was at a suburban location. In 1981 it was moved to a more urban location, but in 1997 it was subsequently moved back to the same suburban location. The daily BJ temperature series, together with those from 18 nearby stations, form a unique database for studying how site‐change and possible urbanisation influences affect climate changes at a local scale. The site‐change‐induced biases were quantified, between 0.43 and 0.95 °C, based on comparisons between multi‐year‐mean seasonal temperature anomalies at BJ and the mean of those from a cluster of nearby stations. The annual mean urban‐suburban difference was 0.81 °C around 1981 and 0.69 °C around 1997, indicating a growing urbanisation effect in the suburban compared to the downtown area. The linear warming trend in the adjusted (for site moves only) BJ temperature series during 1977–2006 was 0.78 °C/decade. Comparing with several rural and less‐urban sites, we suggest that the BJ records include an urbanisation‐related warming bias between 0.20 and 0.54 °C/decade, likely about 0.30 °C/decade, for the recent few decades. The climatic warming at BJ between 1977 and 2006 is likely, therefore, to be about 0.48 °C/decade. Caveats for using these estimates were discussed. Copyright © 2009 Royal Meteorological Society
Effect of fiber distribution and realignment on the nonlinear and inhomogeneous mechanical properties of human supraspinatus tendon under longitudinal tensile loading
Authors: Lake Spencer P. , Miller Kristin S. , Elliott Dawn M. , Soslowsky Louis J. 
Published: June 2009

AbstractTendon exhibits nonlinear stress–strain behavior that may be partly due to movement of collagen fibers through the extracellular matrix. While a few techniques have been developed to evaluate the fiber architecture of other soft tissues, the organizational behavior of tendon under load has not been determined. The supraspinatus tendon (SST) of the rotator cuff is of particular interest for investigation due to its complex mechanical environment and corresponding inhomogeneity. In addition, SST injury occurs frequently with limited success in treatment strategies, illustrating the need for a better understanding of SST properties. Therefore, the objective of this study was to quantitatively evaluate the inhomogeneous tensile mechanical properties, fiber organization, and fiber realignment under load of human SST utilizing a novel polarized light technique. Fiber distributions were found to become more aligned under load, particularly during the low stiffness toe‐region, suggesting that fiber realignment may be partly responsible for observed nonlinear behavior. Fiber alignment was found to correlate significantly with mechanical parameters, providing evidence for strong structure–function relationships in tendon. Human SST exhibits complex, inhomogeneous mechanical properties and fiber distributions, perhaps due to its complex loading environment. Surprisingly, histological grade of degeneration did not correlate with mechanical properties. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:1596–1602, 2009
Erratum: Spherical representation of omnipotent Smith chart
Authors: Wu Yongle , Huang Haiyu , Liu Yuanan , Gao Zehua 
Published: June 2009

AbstractOriginally published Microwave Opt Technol Lett 50: 2452–2455, 2008. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2255, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24515
Erratum: Selective bandpass filter with concentrated impulse response
Authors: Potrebić Milka M. , Tošić Dejan V. 
Published: June 2009

AbstractOriginally published Microwave Opt Technol Lett 50: 2772–2777, 2008. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2255, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24516
Compact monopole antenna for dual ISM‐bands (2.4 and 5.8 GHz) operation
Authors: Jung Jinwoo , Lee Hyeonjin , Lim Yeongseog 
Published: June 2009

AbstractA compact monopole antenna for dual ISM band operation is demonstrated experimentally and numerically. An efficient method for dual band operation of an antenna is presented. Experimental results indicate that the achieved VSWR 2:1 bandwidths were 330 MHz (2.33 to 2.66 GHz) and 420 MHz (5.55 to 5.97 GHz), respectively. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2227–2229, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24519
Design and optimization of Fresnel zone plates using a genetic algorithm and a full‐electromagnetic simulator
Authors: Reid David R. , Smith Glenn S. 
Published: June 2009

AbstractThe optimization of Fresnel zone plates using a genetic algorithm and a the body‐of‐revolution, finite‐difference time‐domain simulator is studied. This technique is applied to zone plates for use in a free‐space, focused‐beam system to measure the electrical properties of materials. The results are compared with a traditionally designed zone plate and a doubly hyperbolic lens. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2223–2227, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24520
Multiband notebook computer antenna design by FDTD method for GSM/WCDMA system applications
Authors: Huang Jhin‐Fang , Wen Jiun‐Yu , Lin Sheng‐Chih 
Published: June 2009

AbstractIn this study, a simple structure designed antenna for 2G and 3G mobile communication applied to notebook computer (NB) is proposed and analyzed by finite difference time domain (FDTD). The proposed antenna has great characteristics of simple structure, easy production, low cost, good impedance matching, and wideband frequency. The antenna main structure is printed on 0.8 mm with permittivity 4.4 FR4 single‐sided PCB, which is bonded to metal bracket. This proposed antenna covers GSM 850/900/1800/1900 and WCDMA multibands and satisfies NB wireless wide area network system. Both FDTD simulation and measurement show that the antenna gain is 2.2 dB for 800 MHz band and 4.6 dB for 1800 MHz band. The 3‐dB passbands are about 136 (824–960 MHz) and 460 MHz (1710–2170 MHz), respectively. The bandwidth of each passband is matched with the desirable values for the NB multiband requirement. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2212–2216, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24521
A novel Gaussian interpolation formula‐based IE‐FFT algorithm for solving EM scattering problems
Authors: Lai Ben , An Xiang , Yuan Hao‐Bo , Chen Zeng‐Shuai , Huang Chun‐Ming , Liang Chang‐Hong 
Published: June 2009

AbstractThe fast Fourier transform‐based integral equation algorithm (IE‐FFT) is a recently developed fast algorithm to solve electrically large problems. The key of the IE‐FFT algorithm is to choose a proper interpolation method, since it not only determines the algorithm's accuracy but also influences the computational complexity and the memory requirement directly. In this article, a novel Gaussian interpolation formula is proposed to optimize the IE‐FFT algorithm for solving EM scattering problems. Compared with the Lagrange interpolation, it can bring with higher accuracy and less memory costs. Furthermore, this interpolation scheme is also well suited for the higher‐order hierarchical basis functions. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2233–2236, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24523
Theory and design of a tunable Quasi‐Lumped Quadrature Coupler
Authors: Ferrero Fabien , Luxey Cyril , Staraj Robert , Jacquemod Gilles , Yedlin Matthew , Fusco Vincent 
Published: June 2009

AbstractIn this article, we present the theory and a design methodology for a tunable Quasi‐Lumped Quadrature Coupler (QLQC). Because of its topology, the coupler is simply reconfigured by switching the bias of two varactor diodes via a very simple DC bias circuitry. No additional capacitors or inductors are required. A prototype at 3.5 GHz is etched on a 0.130‐mm‐thick layer substrate with a dielectric material of relative permittivity of 2.22. The simulated and measured scattering parameters are presented. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2219–2222, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24526
Effect of modulated frequency on ringdown spectrum of single‐mode fiber Fabry‐Perot cavity
Authors: Chen Haiyan 
Published: June 2009

AbstractThe effect of modulated signal frequency on ringdown spectrum of a single‐mode fiber Fabry‐Perot cavity is discussed experimentally. It demonstrates that the beat period is independent of modulated frequency, but the observed beat number is related to modulated frequency. The observed beat number decreases with the increase of modulated frequency. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2216–2219, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24527
Microwave characteristics of substrate integrated waveguide photodetector
Authors: Mortazy Ebrahim , Wu Ke 
Published: June 2009

AbstractIn this article, using a novel structure, simulated and measured microwave characteristics from substrate integrated waveguide photodetector (SIWPD) are obtained and compared with the conventional microstrip waveguide photodetector. A Ka‐band microstrip to rectangular waveguide multilayer transition for OC‐768/STM‐256 optical systems is designed and fabricated. Attenuation constant results shows that by replacing substrate integrated waveguide (SIW) instead of conventional microstrip in waveguide photodetectors, operation frequency can be increased. Microwave fields in the proposed structure show a good transition from quasi‐TEM mode to TE10 mode in multilayer structure. The multilayer structure is considered to separate SIW and DC bias of the photodetector. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2204–2207, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24528
Multiband loop antenna design for mobile devices
Authors: Sim Chow‐Yen‐Desmond , Cheng Po‐Chun , Lee Ching‐Her 
Published: June 2009

AbstractThe design of a novel microstrip‐fed planar antenna for mobile devices operating within the GSM/PCS/DCS/UMTS band is proposed. Besides covering the WLAN, WiBro, and WiMAX spectra, its multiband features are also capable of operating in the GPS/GLONASS and MSS bands if navigation and satellite telecommunication applications are required. Impedance matching for these cases are simply achieved by tuning the slit embedded in the ground plane directly beneath the microstrip feed line. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2242–2248, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24529