bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interstices entre sciences de gestion, sciences de l'ingénieur et psychanalyse
Authors: de Swarte Thibault 
Published: October 2011

Résumé Ce texte cherche tout d’abord à définir ce que peut être un interstice tant de manière générale que dans le champ des sciences de l’ingénieur, de gestion et en psychanalyse. On procède ensuite à une première étude portant sur la dimension fantasmatique et interstitielle de la recherche en informatique. Le point suivant traite des ana-logiques , des discontinuités tant en mathématiques qu’en sciences. Des applications sont données en sciences de l’ingénieur, de gestion et en psychanalyse. On réfléchit tout particulièrement au calcul analogique en sciences versus le dénombrement des analogies en psychanalyse. Le texte se conclut sur ce que les interstices entre ces trois disciplines peuvent apporter aux sciences de gestion : un espace de liberté supplémentaire et une certaine prédictibilité, notamment lorsqu’une organisation dénie de toute ses forces la question de l’imaginaire.
Minimal or No Residual Prostatic Adenocarcinoma on Radical Prostatectomy: A 5-Year Experience With “Vanishing Carcinoma Phenomenon”
Authors: Kosarac Ognjen , Zhai Qihui “Jim” , Shen Steven , Takei Hidehiro , Ro Jae Y. , Ayala Alberto G. 
Published: October 2011

Context.—“Vanishing carcinoma phenomenon” (VC) has been defined as the finding of minute or no cancer on radical prostatectomy specimens after a positive biopsy.Objective.—To discuss our experience with VC and to recommend guidelines for its detection.Design.—One thousand seven hundred forty-one radical prostatectomy specimens (2004–2009) processed by whole-mount section procedure yielded 21 (1.2%) cases with VC and 6 (0.34%) cases with minimal carcinoma (≤2 mm) in the radical prostatectomy specimen. To find the eluding carcinoma in VC cases or more carcinoma in minimal carcinoma cases, the following was done: 3 levels of all the paraffin blocks were obtained; if negative, the paraffin blocks were melted, the tissue was flipped, and 3 levels were prepared. The tumor bank frozen tissue was also processed for routine examination.Results.—Three deeper levels in the radical prostatectomy specimen of 21 VC cases failed to show malignancy; however, the flipping and recutting of the tissue yielded a focus of carcinoma (1–5 mm) in 16 of 21 cases and in 3 of 16 cases in the saved frozen tissue. In 1 of the 6 cases with minimal carcinoma, subsequent recuts of the flipped tissue displayed carcinoma (2 foci of tumor, &lt;1 mm each).Conclusions.—In VC we recommend: embed and process any remaining prostatic tissue including any saved fresh-frozen tissue; obtain 3 levels of each paraffin block; if results are negative, melt and flip the tissue and obtain 3 more levels. Following the above guidelines, a hidden carcinoma may be detected in the majority of the cases of VC.
Assuring Quality in Point-of-Care Testing: Evolution of Technologies, Informatics, and Program Management
Authors: Lewandrowski Kent , Gregory Kimberly , Macmillan Donna 
Published: October 2011

Context.—Managing the quality of point-of-care testing (POCT) is a continuing challenge. Advances in testing technologies and the development of specialized informatics for POCT have greatly improved the ability of hospitals to manage their POCT program.Objectives.—To present the evolving role of technology improvement, informatics, and program management as the key developments to ensure the quality of POCT.Data Sources.—This presentation is based on a review of the literature and on our experiences with POCT at the Massachusetts General Hospital (Boston).Conclusions.—Federal and state regulations, along with accreditation standards developed by the College of American Pathologists and The Joint Commission, have established guidelines for the performance of POCT and have provided a strong incentive to improve the quality of testing. Many instruments for POCT have incorporated advanced design features to prevent analytic and operator errors. This, along with the development of connectivity standards and specialized data management software, has enabled remote review of test data and electronic flow of information to hospital information systems. However, documentation of manually performed, visually read tests remains problematic and some POCT devices do not have adequate safeguards to prevent significant errors. In the past 2 decades the structure of a successful POCT management program has been defined, emphasizing the role of POCT managers working in conjunction with a pathology-based medical director. The critical skill set of POCT managers has also been identified. The POCT manager is now recognized as a true specialist in laboratory medicine.
Niedermolekulare Verbindungen aus Spinnen als chemische Sensoren
Authors: Olsen Christian A. , Kristensen Anders S. , Strømgaard Kristian 
Published: October 2011

AbstractSpinnen sind für viele Ökosysteme wichtig, und als Hauptfeinde von Insekten verfügen sie über eine Fülle von niedermolekularen Naturstoffen mit faszinierenden biologischen Wirkungen. Die Isolierung und die biologische Charakterisierung dieser Verbindungen sind wohlbekannt, aber erst kürzlich wurden sie als Leitstrukturen für die Entwicklung, Synthese und biologische Untersuchung synthetischer Analoga verwendet. Weit weniger erforscht sind hingegen Verbindungen, die der Kommunikation von Spinnen dienen. Vor kurzem wurden jedoch auf dem Gebiet der Pheromone und Allomone aus Spinnen neue Erkenntnisse erhalten, die wir hier zusammenfassen und mit früheren Ergebnissen in Zusammenhang bringen. Abschließend geben wir einen Ausblick auf künftige Untersuchungen an dieser Art von Verbindungen.
Small Molecules from Spiders Used as Chemical Probes
Authors: Olsen Christian A. , Kristensen Anders S. , Strømgaard Kristian 
Published: October 2011

AbstractSpiders are important species in ecological systems and as major predators of insects they are endowed with a plethora of low‐molecular‐weight natural products having intriguing biological activities. The isolation and biological characterization of these entities are well established, however, only very recently have these compounds been used as templates for the design, synthesis, and biological evaluation of synthetic analogues. In contrast, the investigation of compounds responsible for chemical communication between spiders is far less developed, but recently new light has been shed onto the area of pheromones and allomones from spiders. Herein, we recapitulate these recent results, put them into perspective with previous findings, and provide an outlook for future studies of these chemotypes.
An Improved Sliding‐Mode Repetitive Learning Control Scheme Using Wavelet Transform
Authors: Lu Yu‐Sheng , Wu Bing‐Xuan , Lien Shu‐Fen 
Published: October 2011

AbstractThis paper presents an enhanced sliding‐mode repetitive learning control (SMRLC) scheme using the wavelet transform. Distinct from previous wavelet transform‐based repetitive control schemes, the proposed SMRLC learns from a switching signal that is equivalent to the compensation error of the SMRLC, thereby speeding up the learning process. The wavelet analysis is employed to decompose the switching signal, capture its low‐frequency components effectively, and synthesize a de‐noised, high‐scale signal for the learning process. Experimental study on a directly driven Hoekens straight‐line mechanism is conducted, and the proposed wavelet transform‐based SMRLC is experimentally compared with a Fourier series‐based SMRLC.Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
Einsatz eines mobilen NMR‐Sensors als zerstörungsfreies Messsystem in der Bauwerkserhaltung
Authors: Keil Allessandra , Orlowsky Jeanette , Raupach Michael 
Published: October 2011

AbstractDas Potential der NMR‐MOUSE® als mobiles zerstörungsfreies Messsystem im Bereich der Bauwerkserhaltung wird anhand zweier Beispiele erläutert. Das erste Beispiel behandelt den Feuchtetransport in Feinbetonen während im zweiten die Bestimmung der Schichtdicken ausgewählter Oberflächenschutzsysteme dargestellt wird.Mit dem angewendeten Messsystem wurden aussagekräftige Feuchteprofile für Feinbetone bis in eine Messtiefe von 5 mm mit einer Ortsauflösung von 250 µm erstellt. Der zeitliche Verlauf der kapillaren Wasseraufnahme unterschiedlicher Feinbetone kann anhand dieser Feuchteprofile differenziert betrachtet und darüber der Einfluss von Polymerzugaben zum Bindemittel beurteilt werden.Anhand von Tiefenprofilen wurden die Schichtdicken eines Modellsystems und zweier OS 11a‐Beschichtungen zerstörungsfrei mit hoher Auflösung ermittelt. Die Messungen zeigen, dass Schichtdicken von ca. 50 bis 200 µm bei entsprechend gleichmäßigem Auftrag mit einer Standardabweichung von aufgerundet 5 µm bestimmbar sind.Application of a mobile NMR sensor as a non‐destructive measurement system in the field of maintenance. The potential to use the NMR‐MOUSE® as non‐destructive analytical tool in building maintenance is demonstrated on two examples. The first one covers moisture transport through fine grained concrete matrices, whereas in the second one the NMR‐MOUSE is used to determine the layer thickness of selected coating systems for concrete protection.In using this NMR technique, significant moisture profiles have been determined in fine grained concrete matrices with a maximum measuring depth of 5 mm and a depth‐resolution of 250 µm. The NMR technique also allows observing the time depended progress of capillary water uptake and evaluating the effects of polymer modifications of the concrete matrix.Furthermore, the layer thickness of one model coating system and two OS 11a‐coating systems were determined on the basis of depth profiles. The results show, that layer thickness between 50 and 200 µm can be determined with a standard deviation of about 5 µm.
Die Überprüfung von Spannbetonkonstruktionen auf Unversehrtheit der Spannglieder
Authors: Hillemeier Bernd , Walther Andrei 
Published: October 2011

AbstractBrückenbauwerke sind einer ständig steigenden Verkehrslast ausgesetzt. Die Altersstruktur, die Belastungssituation und der Zustand der Brücken sind verschieden. Mehr als 20000 Brücken in Deutschland bestehen aus Spannbeton, deren Stabilität wesentlich von der Unversehrtheit der Spannbewehrung abhängt. Korrosionsschäden an der Spannbewehrung sind von der Oberfläche her nicht sichtbar. An der Technischen Universität Berlin wurde ein mobiles Magnetmesssystem entwickelt, das speziell für Brücken den Zustand der Spanndrähte analysiert. Dazu müssen weder Brückenbereiche geöffnet noch der Fahrbahnbelag entfernt werden. In den letzten zehn Jahren wurden bisher mehr als 14 Spannbetonbrücken, fünf davon in den USA/Kanada, untersucht. Das Verfahren wurde an der Lehigh Universität in Bethlehem (USA) im Zuge einer weltweiten Vergleichsuntersuchung 2009 und 2010 als besonders qualifiziert evaluiert.The inspection of prestressed concrete structures to the integrity of the tendons. Bridges are exposed to an ever‐increasing traffic load. The age structure, the stress situation and the condition of the bridges are different. More than 20000 bridges in Germany are made of prestressed concrete, whose stability depends essentially on the integrity of the tension reinforcement. Corrosion damages to the tension reinforcement are not visible from the surface. At the Technical University of Berlin, a mobile magnetic measurement system has been developed specifically for bridges. It analyzes the state of the tension wires. This system areas not require any removal of the bridge pavement. In the past ten years 14 prestressed concrete bridges have been studied, five of them in the USA/Canada. The process was evaluated at Lehigh University in Bethlehem (USA), as part of a worldwide comparative study in 2009 and 2010.
Quantitation of glucosamine sulfate in plasma by HPLC‐MS/MS after administration of powder for oral solution formulation
Authors: César Isabela Costa , Byrro Ricardo Martins Duarte , de Santana e Silva Cardoso Fabiana Fernandes , Mundim Iram Moreira , de Souza Teixeira Leonardo , Rezende Kênnia Rocha , da Silva Enikson Pontes , Gomes Sandro Antônio , de Sousa Vilmar Alves , Bonfim Ricardo Rodrigues , Pianetti Gerson Antônio 
Published: October 2011

ABSTRACTA rapid method for the quantification of glucosamine in human plasma using high‐performance liquid chromatography coupled to tandem mass spectrometry was developed and validated. The sample preparation includes a simple deproteinization step, using d‐[1‐13C] glucosamine hydrochloride as an internal standard. Chromatographic separation was performed on an ACE Ciano column using isocratic elution with acetonitrile and aqueous 2 mm ammonium acetate containing 0.025% formic acid (80:20). Selected reaction monitoring was performed using the transitions m/z 180.1 → m/z 72.1 and m/z 181.0 → m/z 74.6 to quantify glucosamine and internal standard, respectively. The method was validated and proved to be linear, accurate and precise over the range 50–5000 ng/mL of glucosamine. Recovery rates higher than 90% were obtained for both glucosamine and internal standard. No matrix effect was detected in the samples. The validated method was successfully applied to a pharmacokinetic study after oral administration of a powder for oral solution formulation containing glucosamine sulfate. Copyright © 2011 John Wiley & Sons, Ltd.
In‐Depth Study of Mass Transfer in Nanoporous Materials by Micro‐Imaging
Authors: Hibbe Florian , van Baten Jasper M. , Krishna Rajamani , Chmelik Christian , Weitkamp Jens , Kärger Jörg 
Published: October 2011

AbstractThe first application of interference microscopy to monitoring mass transfer in nanoporous materials dates back to late 1970s when Caro and colleagues reported results of investigations of water uptake by LTA type zeolites. It was, however, not before the beginning of the new millennium that the developments in both the measuring technique and computational power have enabled the recording of transient guest profiles during molecular uptake and release under well‐defined conditions, leading to the establishment of a novel access to diffusion studies, now referred to as micro‐imaging. In the present contribution, the thus accessible novel type of information is illustrated by an in‐depth analysis of the uptake kinetics of methanol in an all‐silica ferrierite. In particular, two remarkable experimental findings are reported, which may be tracked back to their microstructural and/or microdynamic origin, namely a pronounced asymmetry in the transient concentration profiles and a slowing down of guest uptake with increasing temperature.
Detection of malondialdehyde in vivo using microdialysis sampling with CE‐fluorescence
Authors: Cooley Justin Carl , Lunte Craig Edward 
Published: October 2011

AbstractOxidative damage is a naturally occurring process where reactive oxygen species (ROS) attack and disrupt normal cellular function; however, these effects become elevated during a stress event, such as ischemia/reperfusion or seizure. One result of oxidative stress is lipid peroxidation, where ROS attack free unsaturated fatty acids forming lipid hydorperoxides, which then break down to form secondary products acrolein, 4‐hydroxynonenal, and malondialdehyde (MDA) resulting in irreversible membrane damage and ultimately cell death. Described here is a CE‐fluorescence method for the determination of MDA in conjunction with in vivo microdialysis sampling. MDA was derivatized with thiobarbituric acid under acidic conditions for 20 minutes and injected directly into the capillary without any pretreatment. This method provided a limit of detection of 25 nM (S/N=3) and a linear range of 25–2400 nM (1.8–174 ng/mL). This method was used to quantify MDA in rat heart, muscle, liver, and brain dialysate.
Native Chemical Ligation Combined with Desulfurization and Deselenization: A General Strategy for Chemical Protein Synthesis
Authors: Dawson Philip E. 
Published: October 2011

AbstractOf the many approaches proposed to generalize the native chemical ligation approach for protein synthesis, the simple procedure of global desulfurization of peptide thiols has become the most widely adopted. In this review, the development of the native ligation–desulfurization strategy is described, focusing on the conversion of Cys to Ala following ligation at N‐terminal Cys residues. Subsequent variations on this theme have broadened the scope to other natural amino acids including Phe, Leu, Val, and Lys, and even non‐native peptide linkages such as isopeptide bonds on lysine side chains. Using insights from both selenocysteine–peptide side reactions and radical initiated desulfurization procedures, a new method for the selective deselenization of peptides containing both selenocysteine and cysteine residues has been developed. Together, these approaches represent a robust and flexible methodology for the synthesis of complex polypeptides without the use of protecting groups.
New application of optical agent to image angiogenesis in hindlimb ischemia
Authors: Tekabe Yared , Klose Alex , Nizami Saqib , Luma Joane , Lee Francis Y. , Johnson Lynne 
Published: October 2011

AbstractOptical agents targeting αvβ3 are potential tools to image the angiogenic response to limb ischemia. The left (L) femoral artery was ligated in 17 mice and sham surgery performed on the contralateral right (R) hindlimb. Seven days later, IntegriSense (2 nmol) was injected into 11 mice and 6 were probe controls. Six hours later, mice underwent optical imaging. Ratios of photon flux in the L/R limbs were calculated. Tissue was stained for αv, CD31, and lectin. The signal was increased in the ischemic limbs compared to contralateral legs and ratio of photon flux in L/R limb averaged 2.37. Control probe showed no hindlimb signal. IntegriSense colocalized with CD 31 by dual fluorescent staining. Ratios for L/R hindlimbs correlated with quantitative lectin staining (r = 0.88, p = 0.003). Optical imaging can identify and quantify angiogenic response to hindlimb ischemia. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Defined benefit plan headache: Rule changes boost volatility of pension cash flow
Authors: Campbell John L. , Schwartz Jr. William C. 
Published: October 2011

AbstractRecent legislative changes dramatically increase the annual mandatory minimum pension contributions for firms sponsoring defined benefit pension plans. And the rules have also increased the volatility of firm cash flows.In recent years, many firms have made excess contributions to their pension plans—only to see those efforts erased when equity prices dramatically dropped. Companies were chagrined to again find their pension plans significantly underfunded.An unintended consequence of the new legislation is that managing defined benefit plans is now more difficult than ever.So what is the best strategy now?The authors of this article provide specific guidance to CEOs, CFOs, and treasurers‐to help them decide how best to respond to the new funding regulations. © 2011 Wiley Periodicals, Inc.
Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1
Authors: Kirov Aleksandr , Al‐Hashimi Huda , Solomon Phil , Mazur Courtney , Thorpe Philip E. , Sims Peter J. , Tarantini Francesca , Kumar Thallapuranam K. Suresh , Prudovsky Igor 
Published: October 2011

AbstractThe mechanisms of nonclassical export of signal peptide‐less proteins remain insufficiently understood. Here, we demonstrate that stress‐induced unconventional export of FGF1, a potent and ubiquitously expressed mitogenic and proangiogenic protein, is associated with and dependent on the formation of membrane blebs and localized cell surface exposure of phosphatidylserine (PS). In addition, we found that the differentiation of promonocytic cells results in massive FGF1 release, which also correlates with membrane blebbing and exposure of PS. These findings indicate that the externalization of acidic phospholipids could be used as a pharmacological target to regulate the availability of FGF1 in the organism. J. Cell. Biochem. 113: 956–966, 2012. © 2011 Wiley Periodicals, Inc.
MicroRNA‐21 represses human cystathionine gamma‐lyase expression by targeting at specificity protein‐1 in smooth muscle cells
Authors: Yang Guangdong , Pei Yanxi , Cao Qiuhui , Wang Rui 
Published: October 2011

AbstractCystathionine gamma‐lyase (CSE) is the major H2S‐generating enzyme in vascular smooth muscle cells (SMCs). CSE/H2S system contributes to the maintenance of SMC phenotype, and transcript factor specificity protein‐1 (SP1) is a critical regulator of CSE expression during SMC differentiation. The involvements of microRNA‐21 (miR‐21) in cardiovascular pathophysiology have been known, however miR‐21 regulation of CSE and SP1 as well as SMC phenotype are uncertain. Using quantitative real‐time PCR, we demonstrated that the expression of miR‐21 was upregulated in dedifferentiated human aorta SMCs (HASMCs) and injured mouse carotid arteries. To determine the potential roles of miR‐21 in SP1‐mediated CSE gene expression and SMC phenotypic change, we showed that miR‐21 expression was upregulated by miR‐21 precursor. Interestingly, miR‐21 overexpression significantly repressed the protein expressions of both CSE and SP1, inhibited H2S production, stimulated SMC proliferation, and reduced SMC differentiation marker gene expression, respectively. The mRNA expression of CSE but not SP1 was inhibited by miR‐21 precursor. Blockage of SP1 binding by mithramycin or inhibition of CSE activity by DL‐propargylglycine did not change miR‐21 expression. We further demonstrated that miR‐21 repressed SP1 protein expression by directly targeting at SP1 3′ untranslational regions, which in turn downregulated CSE mRNA expression and stimulated SMC proliferation. Take together, these results suggest that miR‐21 participates in CSE/H2S‐mediated‐SMC differentiation by targeting SP1. J. Cell. Physiol. 227: 3192–3200, 2012. © 2011 Wiley Periodicals, Inc.
MRI and “Tenderness Guided” transvaginal ultrasonography in the diagnosis of recto‐sigmoid endometriosis
Authors: Saba Luca , Guerriero Stefano , Sulcis Rosa , Pilloni Monica , Ajossa Silvia , Melis Gianbenedetto , Mallarini Giorgio 
Published: October 2011

AbstractPurpose:To compare the diagnostic accuracy of MRI and “tenderness‐guided” transvaginal ultrasonography (tg‐TVUS) in the identification of recto‐sigmoid endometriosis.Materials and Methods:Institutional Review Board approval for this study was obtained, and written informed consent was given by all patients. This study is compliant with the STARD (Standards for Reporting of Diagnostic Accuracy) method. Fifty‐nine patients (mean age, 33 years; range, 21–44 years) with clinical suspicion of deep pelvic endometriosis were prospectively enrolled. They underwent tg‐TVUS and MRI before surgery. The characteristics of the MRI signal were analyzed. Mapping of recto‐sigmoid endometriosis was performed and tg‐TVUS and MR imaging results were compared with surgical and pathological findings. Sensitivity, specificity, and the positive and negative likelihood ratio (LR+ and LR−) were calculated. Inter‐technique concordance was assessed using the Cohen statistic, and receiver operating characteristic (ROC) curves were obtained. Logistic regression analysis was performed.Results:The prevalence of recto‐sigmoid endometriosis was 51%. The specificity, sensitivity, and LR+ and LR− were 90%, 73%, 7.089 and 0.297, respectively, for MRI and 86%, 73%, 5.317 and 0.309, respectively, for tg‐TVUS. The presence of a high T1 signal spot was an excellent specific finding (100%) but was associated with a low sensitivity (30%). Inter‐technique concordance using the Cohen statistic indicated a kappa value of 0.658 (± 0.098 SD). According to the logistic regression equation obtained, the use of both tg‐TVUS and MRI allows optimal diagnostic performance.Conclusion:MRI and tg‐TVUS show similar results in the identification of recto‐sigmoid endometriosis. The Cohen kappa value suggests that these methods may have complementary roles in the identification of recto‐sigmoid endometriosis, depending on the site affected. J. Magn. Reson. Imaging 2012;352‐360. © 2011 Wiley Periodicals, Inc.