bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mediating effect of self-efficacy on family functioning and psychological resilience in prostate cancer patients
Authors: Zhou Yao , Shan Honglan , Wu Cuigan , Chen Haiyan , Shen Yuanyuan , Shi Wenying , Wang Lina , Li Qinghe 
Published: May 2024

AimsProstate cancer patients face impaired body image and psychological distress during the diagnosis and treatment of the disease, which leads to changes in mood, cognition and behavior. Psychological resilience has been shown to buffer shocks and stresses from the disease. Therefore, this study investigates the relationship between family functioning and psychological resilience in prostate cancer patients and the mediating role of self-efficacy between family functioning and psychological resilience to provide a relevant theoretical basis for improving patients' psychological status by providing relevant theoretical basis.MethodUsing a cross-sectional design, participants were 215 patients with prostate cancer admitted to and treated in a tertiary hospital in Jiangsu province, China. Questionnaires were administered using the general information questionnaire, the Connor-Davidson Resilience Scale (CD-RISC), the Family Adaptation, Partnership, Growth, Affection, and Resolution Index (APGAR), and the General Self-efficacy Scale (GSES). Data were analyzed using descriptive and correlational analyses and the bootstrap mediation test was used to test the effect relationship between the variables.ResultsFamily functioning, self-efficacy and psychological resilience were significantly and positively correlated (r = 0.526, P &lt; 0.01; r = 0.378, P &lt; 0.01; r = 0.358, P &lt; 0.01). The mediating effect of psychological resilience between family functioning and psychological resilience was significant, accounting for 42.56%.ConclusionFamily function and self-efficacy have been shown to increase the level of psychological resilience in prostate cancer patients. Attention should be paid to the mental health problems of prostate cancer patients, early screening and intervention, and the use of patients' family resources to improve their confidence in recovering from the disease, thus increasing their psychological resilience and improving their mental health.
Explaining deep learning-based representations of resting state functional connectivity data: focusing on interpreting nonlinear patterns in autism spectrum disorder
Authors: Kim Young-geun , Ravid Orren , Zheng Xinyuan , Kim Yoojean , Neria Yuval , Lee Seonjoo , He Xiaofu , Zhu Xi 
Published: May 2024

BackgroundResting state Functional Magnetic Resonance Imaging fMRI (rs-fMRI) has been used extensively to study brain function in psychiatric disorders, yielding insights into brain organization. However, the high dimensionality of the rs-fMRI data presents significant challenges for data analysis. Variational autoencoders (VAEs), a type of neural network, have been instrumental in extracting low-dimensional latent representations of resting state functional connectivity (rsFC) patterns, thereby addressing the complex nonlinear structure of rs-fMRI data. Despite these advances, interpreting these latent representations remains a challenge. This paper aims to address this gap by developing explainable VAE models and testing their utility using rs-fMRI data in autism spectrum disorder (ASD).MethodsOne-thousand one hundred and fifty participants (601 healthy controls [HC] and 549 patients with ASD) were included in the analysis. RsFC correlation matrices were extracted from the preprocessed rs-fMRI data using the Power atlas, which includes 264 regions of interest (ROIs). Then VAEs were trained in an unsupervised manner. Lastly, we introduce our latent contribution scores to explain the relationship between estimated representations and the original rs-fMRI brain measures.ResultsWe quantified the latent contribution scores for both the ASD and HC groups at the network level. We found that both ASD and HC groups share the top network connectivitives contributing to all estimated latent components. For example, latent 0 was driven by rsFC within ventral attention network (VAN) in both the ASD and HC. However, we found significant differences in the latent contribution scores between the ASD and HC groups within the VAN for latent 0 and the sensory/somatomotor network for latent 2.ConclusionThis study introduced latent contribution scores to interpret nonlinear patterns identified by VAEs. These scores effectively capture changes in each observed rsFC feature as the estimated latent representation changes, enabling an explainable deep learning model that better understands the underlying neural mechanisms of ASD.
Examining associations between physical activity context and children meeting daily physical activity guidelines: the role of outdoor play, sports, and other organized activities
Authors: Pfledderer Christopher D. , Brown Denver M. Y. , Ranjit Nalini , Springer Andrew E. , Malkani Raja I. , Salvo Deborah , Hoelscher Deanna M. 
Published: May 2024

BackgroundLess than one-quarter of US children meet physical activity (PA) guidelines. Understanding the context in which PA occurs and how these contexts may play a role in meeting PA guidelines is an essential step toward developing effective behavioral interventions. The purpose of this study was to examine associations between PA context (sports participation, participation in other organized physical activities, active travel to school, and outdoor play) and the number of days children met PA guidelines in a representative sample of children living in Texas.MethodsWe analyzed cross-sectional data from a statewide sample of fourth-grade children in Texas who completed the 2019–2020 Texas School Physical Activity and Nutrition (Texas SPAN) survey. The Texas SPAN survey was designed to monitor the statewide prevalence of overweight/obesity among school children and assess habitual self-reported obesity-related behaviors, including diet and PA. Weighted Poisson regression models were employed to examine the associations between PA contexts (sports participation, participation in other organized physical activities, active travel to school, and outdoor play) and the number of days children met PA guidelines, adjusting for sex, race/ethnicity, overweight/obesity, urban–rural status, and economic disadvantage.ResultsA total of 16.7% of fourth-grade children met physical activity guidelines every day during the week (mean age = 9.4 ± 0.6 years; female = 48.7, 51.8% Hispanic, mean days meeting PA guideline = 3.6 ± 2.3 days). One in ten (11.2%) children did not meet daily PA guidelines on any day of the week, and 72.1% met them between 1 and 6 days. Participating in sports (b = 0.22, 95%CI:0.14, 0.30), any other organized physical activities (b=0.13, 95%CI:0.017, 0.19), and playing outdoors 1–3 days (b = 0.25, 95%CI:0.04, 0.46) and 4–7 days in the past week (b = 0.77, 95%CI:0.57, 0.97) was significantly and positively associated with the number of days children met PA guidelines.ConclusionParticipating in sports, participating in other organized physical activities, and playing outdoors may beneficially influence the number of days children meet PA guidelines. PA programs should consider these contextual factors and investigate how to promote organized activities and outdoor play effectively and appropriately among children.
Type 2 diabetes attributable to ambient particulate matter pollution: a global burden study from 1990 to 2019
Authors: Sha Yuyi , Wang Shuai 
Published: May 2024

BackgroundThis study assesses the changes over time and geographical locations in the disease burden of type 2 diabetes (T2D) attributed to ambient particulate matter pollution (APMP) from 1990 to 2019 in 204 countries and regions with different socio-demographic indexes (SDI).MethodsThe Global Burden of Diseases Study 2019 (GBD2019) database was used to analyze the global burden of T2D attributed to APMP. This study evaluated both the age-standardized death rate (ASDR) and disability-adjusted life years (DALYs) related to T2D, comparing data from 1990 to 2019. Estimated Annual Percentage Changes (EAPCs) were also utilized to investigate the trends over the 30-year study period.ResultsThe global age-standardized DALY rate and ASDR exhibited an increasing trend, with an EAPC of 2.21 (95% CI: 2.15 to 2.27) and 1.50 (95% CI: 1.43 to 1.58), respectively. This rise was most notable among older adult populations, men, regions in Africa and Asia, as well as low-middle SDI regions. In 2019, the ASDR for T2D caused by APMP was recorded at 2.47 per 100,000 population, while the DALY rate stood at 108.98 per 100,000 population. Males and countries with middle SDI levels displayed significantly high age-standardized death and DALY rates, particularly noticeable in Southern Sub-Saharan Africa. Conversely, regions with high SDI levels like High-income North America demonstrated decreasing trends.ConclusionThis study reveals a significant increase in T2D worldwide as a result of APMP from 1990 to 2019, with a particular emphasis on its impact on men, the older adult, and regions with low to middle SDI levels. These results underscore the urgent necessity for implementing policies aimed at addressing air pollution in order to reduce the prevalence of T2D, especially in the areas most heavily affected.
Meta-analysis and systematic review of gout prevalence in the heart/lung transplantation population
Authors: Chui Benedict , Day Richard , Umashankar Eshwar , Abdel Shaheed Christina , Keogh Anne , Girgis Laila , Penglase Ross 
Published: May 2024

IntroductionGout may complicate solid organ transplantation with potentially serious consequences. An accurate prevalence of gout in this population is unknown.ObjectivesThis study aimed to estimate the prevalence of gout in the heart and/or lung transplantation population through a systematic review and meta-analysis.MethodsMEDLINE, Embase, PsycINFO, CENTRAL and Cochrane Library (inception to February 2022) were searched for studies that reported the prevalence and/or incidence of gout in heart and/or lung transplant recipients. Two authors extracted outcomes data. Data were pooled using a random effects model. Overall quality of evidence was assessed using GRADE. Primary outcomes were the prevalence of pre- or post-transplant gout expressed as a prevalence rate (95% CI). Secondary outcomes included risk factors for gout, adverse events, and therapeutic complications of gout treatment.ResultsTen studies were included. Gout prevalence (PR) was 8% pre-transplant (PR = 0.08; 95% CI: 0.05–0.12; 4 studies n = 651) and 6% post-transplant (PR = 0.06; 95% CI: 0.06–0.06; 10 studies n = 45,298). Post-transplant gout prevalence in heart transplant recipients was almost three times higher than lung transplant recipients (PR = 0.16; 95% CI: 0.13–0.20 vs. PR = 0.06; 95% CI: 0.05–0.06 respectively). Patients with a pre-transplant history of gout had a higher risk of developing post-transplant gout than patients without (RR = 3.61; 95% CI: 2.19–5.95). Factors associated with gout and outcomes for heart and/or lung transplant recipients with gout were comprehensively reviewed from the included studies.ConclusionGout is highly prevalent in heart and/or lung transplant patients. Pre-transplant gout is predictive of developing symptomatic post-transplant gout. This has significant implications for management of heart/lung transplant patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO (CRD42020190632).
Kinematics but not kinetics alterations to single-leg drop jump movements following a subject-tailored fatiguing protocol suggest an increased risk of ACL injury
Authors: Nardon Mauro , Ferri Umberto , Caffi Giovanni , Bartesaghi Manuela , Perin Cecilia , Zaza Antonio , Alessandro Cristiano 
Published: May 2024

IntroductionNeuromuscular fatigue causes a transient reduction of muscle force, and alters the mechanisms of motor control. Whether these alterations increase the risk of anterior cruciate ligament (ACL) injury is still debated. Here we compare the biomechanics of single-leg drop jumps before and after the execution of a fatiguing exercise, evaluating whether this exercise causes biomechanical alterations typically associated with an increased risk of ACL lesion. The intensity of the fatiguing protocol was tailored to the aerobic capacity of each participant, minimizing potential differential effects due to inter-individual variability in fitness.MethodsTwenty-four healthy male volunteers performed single leg drop jumps, before and after a single-set fatiguing session on a cycle ergometer until exhaustion (cadence: 65–70 revolutions per minute). For each participant, the intensity of the fatiguing exercise was set to 110% of the power achieved at their anaerobic threshold, previously identified by means of a cardiopulmonary exercise test. Joint angles and moments, as well as ground reaction forces (GRF) before and after the fatiguing exercise were compared for both the dominant and the non-dominant leg.ResultsFollowing the fatiguing exercise, the hip joint was more extended (landing: Δ=−2.17°, p = 0.005; propulsion: Δ=−1.83°, p = 0.032) and more abducted (landing: Δ=−0.72°, p = 0.01; propulsion: Δ=−1.12°, p = 0.009). Similarly, the knee joint was more extended at landing (non-dominant leg: Δ=−2.67°, p &lt; 0.001; dominant: Δ=−1.4°, p = 0.023), and more abducted at propulsion (both legs: Δ=−0.99°, p &lt; 0.001) and stabilization (both legs: Δ=−1.71°, p &lt; 0.001) hence increasing knee valgus. Fatigue also caused a significant reduction of vertical GRF upon landing (Δ=−0.21 N/kg, p = 0.003), but not during propulsion. Fatigue did not affect joint moments significantly.ConclusionThe increased hip and knee extension, as well as the increased knee abduction we observed after the execution of the fatiguing exercise have been previously identified as risk factors for ACL injury. These results therefore suggest an increased risk of ACL injury after the execution of the participant-tailored fatiguing protocol proposed here. However, the reduced vertical GRF upon landing and the preservation of joint moments are intriguing, as they may suggest the adoption of protective strategies in the fatigued condition to be evaluated in future studied.
Donor Blood Tests do Not Predict Pancreas Graft Survival After Simultaneous Pancreas Kidney Transplantation; a National Cohort Study
Authors: Ho Ning Xuan , Tingle Samuel J. , Malik Abdullah K. , Thompson Emily R. , Kourounis Georgios , Amer Aimen , Pandanaboyana Sanjay , Wilson Colin , White Steve 
Published: May 2024

Simultaneous pancreas-kidney (SPK) transplantation improves quality of life and limits progression of diabetic complications. There is reluctance to accept pancreata from donors with abnormal blood tests, due to concern of inferior outcomes. We investigated whether donor amylase and liver blood tests (markers of visceral ischaemic injury) predict pancreas graft outcome using the UK Transplant Registry (2016-2021). 857 SPK recipients were included (619 following brainstem death, 238 following circulatory death). Peak donor amylase ranged from 8 to 3300 U/L (median = 70), and this had no impact on pancreas graft survival when adjusting for multiple confounders (aHR = 0.944, 95% CI = 0.754–1.81). Peak alanine transaminases also did not influence pancreas graft survival in multivariable models (aHR = 0.967, 95% CI = 0.848–1.102). Restricted cubic splines were used to assess associations between donor blood tests and pancreas graft survival without assuming linear relationships; these confirmed neither amylase, nor transaminases, significantly impact pancreas transplant outcome. This is the largest, most statistically robust study evaluating donor blood tests and transplant outcome. Provided other factors are acceptable, pancreata from donors with mild or moderately raised amylase and transaminases can be accepted with confidence. The use of pancreas grafts from such donors is therefore a safe, immediate, and simple approach to expand the donor pool to reach increasing demands.
Genome-Wide Identification and Expression Profiles of IMB Genes Reveal Their Potential Roles in the Gametophytic Sexual Reproduction Process of Camellia sinensis
Authors: Xu Xiaohan , Xing Anqi , Wu Zichen , Sun Yi , Xu Xuefeng , Liu Shujing , Zhao Zhen , Chen Xuan , Li Xinghui , Wang Yuhua 
Published: May 2024

It is of great significance to explore the molecular mechanism of gametophytic sexual reproduction in the genetic improvement and breeding of tea plants [Camellia sinensis (L.) O. Kuntze]. Imported beta family members (IMBs) are a class of widely distributed nucleoplasmic transport receptor proteins in eukaryotes, affecting plant development and reproduction, and participating in flowering time and sexual reproduction. Still missing, though, is a thorough examination of IMB members in tea plants. Here, seven members of the IMB gene family were screened by a genome-wide investigation in tea plants. These members were scattered unevenly throughout five chromosomes. All of them contained the conserved KAP95 and HEAT Repeat domains. Additionally, the promoter regions of CsIMBs harbored cis-acting elements associated with plant hormones, light, and abiotic stress responses. In order to further confirm the function of CsIMBs in the sexual reproduction of tea plants, the expression patterns of CsIMBs in different flower development stages and the ovary (before and after pollination) were analyzed. The expression results highlighted that CsIMBs were related to the fertility and fruiting of tea plants. Furthermore, five of the seven CsIMBs (CsIMB1a, CsIMB1b, CsIMB2, CsIMB3a, and CsIMB3b) were found to be localized in the nucleus revealed by subcellular localization analysis. These results offer a comprehensive characterization of IMB genes as well as insights into the potential roles of CsIMBs participating in the gametophytic sexual reproduction of C. sinensis.
Docking Proteins Upregulate IL-1β Expression in Lower Esophageal Sphincter Muscle in Esophageal Achalasia
Authors: Kanda Tsutomu , Saiki Karen , Kurumi Hiroki , Yoshida Akira , Ikebuchi Yuichiro , Sakaguchi Takuki , Urabe Shigetoshi , Minami Hitomi , Yamaguchi Naoyuki , Nakao Kazuhiko , Inoue Haruhiro , Isomoto Hajime 
Published: May 2024

Background/Objectives: Esophageal achalasia is an archetypal esophageal motility disorder characterized by abnormal peristalsis of the esophageal body and impaired lower esophageal sphincter (LES) relaxation. Methods: In this study, the mRNA expression of docking proteins 1 and 2 (DOK1 and DOK2, respectively) were analyzed and the mechanisms underlying achalasia onset were investigated. Results: DOK1 and DOK2 mRNA levels significantly increased in the LES of patients with achalasia. Moreover, significant correlations were observed between IL-1β and DOK1, IL-1β and DOK2, ATG16L1 and DOK1, and HSV1-miR-H1-3p and DOK2 expression levels. However, a correlation between ATG16L1 and DOK2 or between HSV-miR-H1-3p and DOK1 expression was not observed. In addition, a positive correlation was observed between patient age and DOK1 expression. Microarray analysis revealed a significant decrease in the expression of hsa-miR-377-3p and miR-376a-3p in the LES muscle of patients with achalasia. Conclusions: These miRNAs possessed sequences targeting DOK. The upregulation of DOK1 and DOK2 expression induces IL-1β expression in the LES of achalasia patients, which may contribute to the development of esophageal motility disorder.
Ansiedad, depresión y calidad del sueño en estudiantes de Odontología
Authors: Roque Huanca Edgar Octavio , Chui Betancur Heber Nehemias , Padilla Caceres Tania Carola , Aguilar Velasquez Roberto Anacleto , Mamani Roque Maribel 
Published: May 2024

La calidad del sueño en los estudiantes es un factor esencial que influye en el correcto desarrollo de los procesos cognitivos del aprendizaje, así como en la calidad de vida y la salud mental y física de los futuros profesionales. Objetivo: Evaluar la relación entre la ansiedad, la depresión y la calidad del sueño en estudiantes de la carrera de Odontología de la Universidad Nacional del Altiplano de Puno. Materiales y métodos: Estudio de tipo observacional de cohorte transversal con la participación de 78 estudiantes, con edad promedio de 22.63±2.87 años, con una distribución de género de 32 varones (41,0 %) y 46 mujeres (59,0 %). Se utilizó la escala de valoración de Hamilton para la evaluación de la ansiedad y la depresión, con una consistencia interna de ? = 0,88 y 0,86, respectivamente y el cuestionario de Pittsburgh para medir el índice de calidad del sueño (? = 0,87). Resultados: En el modelo predictivo los coeficientes estandarizados ? señalan que la ansiedad psíquica (? = -,870; p<0,001), la depresión (? = ,119; p<0,05) y el desarrollo de prácticas clínicas (? = -0,019; p<0,05) fueron los factores que más contribuyeron significativamente al índice de calidad del sueño de los estudiantes. Conclusión: Estos hallazgos subrayan la importancia de abordar los problemas del sueño como parte integral del tratamiento de la ansiedad y la depresión, además de resaltar la necesidad de tener en cuenta la salud mental en la evaluación y el manejo de los trastornos del sueño.
Experiencia laboral y percepción del personal sanitario de Perú durante la pandemia de COVID-19
Authors: Becerra Goicochea Lorena Judith , Alvarado Santos Alfonso Dedicación , Núñez Mejía Janner Alexis , Uriarte Torres Rosa Del Pilar 
Published: May 2024

La pandemia de COVID-19 representó un gran desafío para los profesionales de la salud de Perú, debido al riesgo elevado de contagio, la sobrecarga laboral y afectación de la salud mental. Objetivo: Describir las experiencias laborales y percepciones del personal sanitario de este país durante la pandemia de COVID-19. Materiales y Métodos: Se llevó a cabo un estudio cualitativo fenomenológico, en el que se realizaron ocho entrevistas semiestructuradas a profesionales de la salud pública en Perú entre mayo y diciembre del año 2020. Las mismas fueron grabadas y transcritas para la recolección de la información, las cuales se analizaron en categorías. Resultados: En las entrevistas realizadas se destacaron los desafíos organizativos y de recursos, como la escasez de equipos de protección personal y gestión burocrática. Se resaltó el impacto humano y social en términos de comunicación, empatía y reevaluación de valores personales. Se observó adaptaciones significativas en la práctica médica, con énfasis en el manejo de pacientes y la capacitación. Conclusiones: Las experiencias clínicas y emocionales reflejaron los retos y motivaciones del personal sanitario durante la pandemia; en el que se demostró la necesidad de una mayor adaptabilidad y preparación, así como la importancia del bienestar emocional y social.
PEMBINAAN DAN PELATIHAN TATA KELOLA ADMINISTRASI DAN KEUANGAN PADA BUMDES MULIA JAYA ABADI DESA RESAM LAPIS
Authors: Supriati Supriati , Nurhazana Nurhazana 
Published: May 2024

Tujuan kegiatan pengabdian ini adalah untuk memberikan pembinaan dan pelatihan tata kelola administrasi dan keuangan pada BumDes Resam Lapis. Kegiatan ini diusulkan atas permintaan dari Direktur BumDes Mulia Jaya Abadi yaitu Bapak Muhammad Fariz disampaikan pada Focus Group Discusssin (FGD) pada tanggal 28 April 2021 di kantor P3M Polbeng. Kegiatan ini diharapkan akan mendapatkan pengetahuan, pemahaman dan kemampuan mengelola dan mencatat laporan keuangan BumDes bagi pengurus operasionalnya. Target kegiatan ini adalah seluruh pengurus BumDes Mulia Jaya Abadi Resam Lapis. Metode yang digunakan adalah pembinaan dan pelatihan. Luaran kegiatan (Output) adalah terselenggaranya kegiatan pembinaan dan pelatihan tentang tata kelola administrasi dan laporan keuangan BumDes dan unit usahanya, serta sosialisasi hasil program dalam seminar atau media. Dampak (outcome) kegiatan ini adalah meningkatnya pengetahuan dan keterampilan dalam mengelola administrasi dan pencatatan laporan keuangan BumDes Mulia Jaya Abadi Resam Lapis, dan terjalinnya hubungan harmonis antara Polbeng dan masyarakat.Kata Kunci: Administrasi, Keuangan, BumDes