bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remdesivir in Severe Cases of COVID-19 Infection
Authors: Boretti Alberto 
Published: May 2024

Background:
Assessing the efficacy of remdesivir for COVID-19 infection holds historical
significance. Understanding its effectiveness from previous pandemic instances can enable
us to gain insights into its efficacy, informing our strategies for responding to future outbreaks or
variants.

Objective:
Gaining an insight into the historical efficacy of remdesivir can offer valuable data for
evaluating the advancement of COVID-19 treatments and the development of medical expertise in
handling the disease.

Method:
The historical data regarding the effectiveness of remdesivir can enrich the pool of
knowledge and evidence accessible for public health planning and decision-making. Understanding
whether remdesivir was efficacious in previous instances may aid in comprehending its real-world
impact on patient outcomes at those times. Such insights are crucial for evaluating treatment efficacy
and refining strategies based on past experiences.

Results:
In the late treatment of severe COVID-19 cases, which are particularly challenging,
remdesivir has demonstrated a 6% improvement.

Conclusion:
The 6% enhanced effect of remdesivir is not substantial, considering that it is an unweighted
average of works with varying degrees of importance and reliability. Additionally, there
are instances where conflicts of interest may have impacted the results. It is also possible that the
observed improvement could be attributed to better patient care in certain environments.
Comprehensive Allopathic Treatment and Retrospective Ayurvedic Regime
Post-snake Bite from Southern Russell’s Viper (Daboia russelii) for Wound
Healing and Joint Stiffness - A Case Report
Authors: Ramanna Kumar Jajur , Prasad Nagalambika , Hamse Vivek Kameshwar , Kullanakoppalu Lokesh Chandan , Balan Gurumurthy , Dugganaboyana Guru Kumar , Abdurahman Syed , Nagaraju Kumar Kiran Mudnakudu , Chikkamandagere Kumar Anusha , Fathima Noor , Venkatesh Chandavi 
Published: May 2024

Background:
In India and other tropical nations, snake bites are a serious public health issue that anti-snake venom may effectively treat.

Case Presentation:
The case report described here details the antivenom received to neutralize the toxins present in Russell’s viper venom, followed by Ayurveda treatment to remove the surgical wound and reduce joint stiffness by applying Ayurvedic paste prepared by Laportea aestuans (L.). The leaves, garlic, pepper, and lemon juice mixture was applied to the affected area twice daily for 10 days. Another thin paste consisting of Laportea aestuans (L.) leaves, Centella asiatica (L.), garlic, pepper, and lemon juice was applied every 30 minutes for 10 days. A dried medicated paste was prepared by heating coconut oil and dried neem tree peel and applied to the wound. The patient was also given a decoction of Randia dumetorum (Retz.) Poir nut extracted with milk to flush out the venom.

Conclusion:
The present results suggest combining conventional allopathic treatment to heal the surgical wound and Ayurvedic treatments to manage the symptoms of a juvenile Russell's viper bite as effective.
Elementary Teacher Leadership of Pioneer Teacher Program Alumnae in Yogyakarta City
Authors: Brilatin Ares , Wibowo Setiawan Edi 
Published: May 2024

This research examines the leadership of Pioneer Teacher Program (Guru Penggerak) graduates at the primary school level in Yogyakarta City. It is a descriptive qualitative research. This research applies educational sociology approach, particularly the role of teachers. Data was collected from interviews and literature reviews. The data analysis is based on the theory of teachers as leaders by Frank Crowther (1997). The results of this research: first, GP graduates of the Pioneer Teacher Program have successfully improved their quality and professionalism in the leadership. This improvement is manifested in proactive involvement in various leadership activities. Second, the Self-Efficacy of Prioneer Teacher is not prevalent. Some GP members face personal and casuistic issues, where their lack of confidence emerges when faced with strategic leadership positions, such as being a school principal. The research findings controvert the common narrative that the Pioneer Teacher Program produces successful teachers without any obstacles. These findings serve as a recommendation for the future Pioneer Taecher Program to emphasize and pay more attention to the self-confidence of its graduates in strategic leadership positions within their respective institutions.
Prediction of Hearing Help Seeking to Design a Recommendation Module of an mHealth Hearing App: Intensive Longitudinal Study of Feature Importance Assessment
Authors: Angonese Giulia , Buhl Mareike , Kuhlmann Inka , Kollmeier Birger , Hildebrandt Andrea 
Published: May 2024

Background
Mobile health (mHealth) solutions can improve the quality, accessibility, and equity of health services, fostering early rehabilitation. For individuals with hearing loss, mHealth apps might be designed to support the decision-making processes in auditory diagnostics and provide treatment recommendations to the user (eg, hearing aid need). For some individuals, such an mHealth app might be the first contact with a hearing diagnostic service and should motivate users with hearing loss to seek professional help in a targeted manner. However, personalizing treatment recommendations is only possible by knowing the individual’s profile regarding the outcome of interest.

Objective
This study aims to characterize individuals who are more or less prone to seeking professional help after the repeated use of an app-based hearing test. The goal was to derive relevant hearing-related traits and personality characteristics for personalized treatment recommendations for users of mHealth hearing solutions.

Methods
In total, 185 (n=106, 57.3% female) nonaided older individuals (mean age 63.8, SD 6.6 y) with subjective hearing loss participated in a mobile study. We collected cross-sectional and longitudinal data on a comprehensive set of 83 hearing-related and psychological measures among those previously found to predict hearing help seeking. Readiness to seek help was assessed as the outcome variable at study end and after 2 months. Participants were classified into help seekers and nonseekers using several supervised machine learning algorithms (random forest, naïve Bayes, and support vector machine). The most relevant features for prediction were identified using feature importance analysis.

Results
The algorithms correctly predicted action to seek help at study end in 65.9% (122/185) to 70.3% (130/185) of cases, reaching 74.8% (98/131) classification accuracy at follow-up. Among the most important features for classification beyond hearing performance were the perceived consequences of hearing loss in daily life, attitude toward hearing aids, motivation to seek help, physical health, sensory sensitivity personality trait, neuroticism, and income.

Conclusions
This study contributes to the identification of individual characteristics that predict help seeking in older individuals with self-reported hearing loss. Suggestions are made for their implementation in an individual-profiling algorithm and for deriving targeted recommendations in mHealth hearing apps.
Use of Transdermal Alcohol Sensors in Conjunction With Contingency Management to Reduce Alcohol Consumption in People With Alcohol Dependence Attending Alcohol Treatment Services: Protocol for a Pilot Feasibility Randomized Controlled Trial
Authors: Brobbin Eileen , Deluca Paolo , Parkin Stephen , Drummond Colin 
Published: May 2024

Background
Wearable technology for objective, continuous, and reliable alcohol monitoring has been developed. These are known as transdermal alcohol sensors (TASs). They can be worn on the wrist or ankle with the sensor pressed against the skin and can measure sweat vapors being emitted from the skin, to record transdermal alcohol concentration (TAC). Previous studies have investigated the accuracy and acceptability of the available TAS brands, but there has been little research into their use in people with alcohol use disorders (AUD).

Objective
This feasibility randomized controlled trial aims to explore the feasibility, strengths, and limitations of using a TAS to monitor alcohol consumption in individuals in treatment for AUD with or without contingency management (CM) to promote abstinence or low-level alcohol consumption.

Methods
The target sample size is 30 (15 randomized to each group). Participants will be recruited through poster adverts at alcohol services. Both groups (control and CM) will wear the TAS (BACtrack Skyn) for 2 weeks in the context of their usual treatment, meeting with the researcher every other weekday. In the last meeting, the participants will complete a postwear survey on their experience of wearing the TAS. The CM group will also receive small financial incentives for low or no alcohol consumption, as measured by the TAS. On days where the TAC peak is below a set threshold (<115.660 g/L), CM group participants will be rewarded with a £5 (US $6.38) voucher. There are financial bonuses if this target is achieved on consecutive days. The researcher will monitor TAC for each day of the study at each research visit and allocate financial incentives to participants according to a set reinforcement schedule.

Results
The first participant was enrolled in June 2023, and the last in December 2023. Data analysis is underway and is estimated to be completed by June 2024. A total of 32 participants were enrolled.

Conclusions
Most TAS brands have had limited application in clinical settings, and most studies have included healthy adults rather than people with AUD. TAS has the potential to enhance treatment outcomes in clinical alcohol treatment. The accuracy, acceptability, and feasibility of TAS for people with AUD in clinical settings need to be investigated. This is the first study to use TAS in specialized alcohol services with diagnosed AUD individuals currently receiving treatment from a south London alcohol service.

Trial Registration
ISRCTN Registry ISRCTN46845361; https://www.isrctn.com/ISRCTN46845361

International Registered Report Identifier (IRRID)
DERR1-10.2196/57653
Enhancing Anticancer Potential: Investigating the Synergistic Impact of Doxorubicin and Curcumin on HeLa and Vero Cells in Vitro
Authors: Aristiani Windy , Desvita Widea Rossi , Khayatulisma Dika , Edityaningrum Citra Ariani , Guntarti Any , Nurani Laela Hayu 
Published: May 2024

(1) Background: Cervical cancer ranks as the fourth most prevalent cancer globally and in Asia, standing as the second most common in Indonesia. Despite its efficacy, doxorubicin chemotherapy is associated with significant side effects. To mitigate these adverse effects, a promising approach involves combining conventional drugs with curcumin. Both curcumin and doxorubicin have demonstrated cytotoxic effects against cervical cancer (HeLa). This research aims to determine the synergistic effect of the combination of doxorubicin and curcumin on HeLa and safety in normal cells (Vero cells). (2) Methods: This study adopted an experimental design utilizing doxorubicin and curcumin samples with HeLa and Vero cells. The investigation was initiated with cytotoxic and combination tests using the MTT method. The obtained results included IC50 values and combination indices, and the analysis involved a comparative examination of outcomes between HeLa and Vero cells. (3) Results: Cytotoxic tests revealed IC50 values for doxorubicin and curcumin on HeLa cells, measured in 2,17 ± 0,06 and 26,37 ± 2,00 µg/mL, and 17,32 ± 1,99 and 181,88 ± 30,48 µg/mL on Vero cells. Combination test results were represented by combination index .(4) Conclusions: The synergistic effect is observed at the combination of curcumin at a concentration of 9 μg/mL and doxorubicin at a concentration of 0,125 μg/mL, resulting in a combination index of 0,50. These findings suggest a promising avenue for enhancing the therapeutic potential of doxorubicin in cervical cancer treatment while minimizing adverse effects.
Changes in CA 125 Level Pre and Post Ovarian Cancer Surgery
Authors: Aprivinta Sherlyana Mega , Pradjatmo Heru , Hadiati Diah Rumekti 
Published: May 2024

Background: Ovarian cancer is one of the gynecological cancers that has a fairly high mortality rate and has a poor prognosis. Ovarian cancer management includes optimal operation followed by chemotherapy, which at follow up will have an effect on decreasing CA 125 levels. But in fact there are several studies showing increased CA 125. Given these differences in findings, this study attempted to evaluate the pre and post operation changes in CA 125 levels in ovarian cancer patients.Objective: This study aims to determine the changes in pre and post operation CA 125 levels in ovarian cancer patients. And to find out the optimal relationship between CA 125 level post operation and post operation.Methods: The type of research is an analytic study with a prospective cohort design. The source comes from secondary data taken from Simetris dr. Sardjito Hospital within 6 months.Results: The distribution of the age < 40 years was 11 and 19 were 40 years old. There was a significant change in pre operation log CA 125 levels (mean = 2,53 or 902,03U/ml) and post operation log CA 125 levels (mean = 1,92 or 406,23 U/ml). With a difference or delta mean of 0,61 or 495,80 U/ml and p value = 0.001. There was a significant difference in post operation log CA 125 levels between optimal and non optimal operation. Based on risk factors, there was a significant change or decrease in log CA 125 levels pre and post operation, but there was no significant difference in log CA 125 levels pre and post operation.Conclusion: There was a significant decrease in log CA 125 levels pre and post operation in patients with ovarian cancer who underwent operation. The post operation log CA 125 level in optimal operation is lower than in non-optimal operation.Keywords: CA 125, Ovarian Cancer, Operation, Optimal
3D Reconstruction and Nuclear Analytical Investigations of Tropaeum Traiani Monument, Adamclisi
Authors: Ion Rodica-Mariana , Bakirov Bulat A. , Kichanov Sergey E. , Gheboianu Anca Irina , Slămnoiu-Teodorescu Sofia 
Published: May 2024

Abstract
The paper aims to conduct a novel investigation of ceramic samples from the Trophaeum Traiani Monument in Romania using various nuclear analytical techniques such as WDXRF, XRD, neutron diffraction, and neutron tomography, which will be complemented by FTIR and Raman spectroscopy data. The experimental data gathered revealed the mineral and chemical composition of the object’s surface, identifying quartz, hematite, calcite, and graphite. The employment of non-destructive techniques with high penetration capabilities is adequate in examining the spatial distribution and phase composition of the samples, providing valuable insights into their composition and structure without altering their integrity.
Silver Nanoparticles in Food Bio Packaging. A Short Review
Authors: Angelescu Nicolae , Grigorescu Daniela , Ungureanu Dan Nicolae 
Published: May 2024

Abstract
For human survival, the agri-food sector is fundamental, starting from the cultivation of the land to the production of food that ends up on our tables. Unfortunately, over time, this sector has faced numerous challenges, such as the appearance of pests, environmental pollution, short shelf life and, last but not least, inadequate packaging materials. All these challenges have led researchers from all over the world to find new alternatives to guarantee food safety. The application of nanomaterials, i.e. nanoparticles, could be the solution sought by all scientists. In recent years, nanotechnology has made remarkable progress, especially regarding the application of metallic nanoparticles and their synthesis methods. In particular, silver nanoparticles have attracted attention, due to their special antimicrobial, electrical and optical properties, but also to the fact that they can be combined with nondegradable, biodegradable and edible polymers. However, there are many concerns regarding the toxicity of these nanoparticles. This article aims to present some recent findings regarding the application of silver nanoparticles in food bio packaging.
Music in the mind and primitive sounds: «only differences in kind»
Authors: Candelieri Irene 
Published: May 2024

Summary
During his prolific career, the German Jewish scientist Franz Boas (Minden, 1858 - New York, 1942) recognized as the founding father of American Cultural Anthropology – maintained assiduous contacts with the European scientific community, in a privileged way with that of the German area. The contribution addresses the Boasian correspondence with the two directors of the Berliner Phonogramm-Archiv, the philosopher and psychologist Carl Stumpf, and the ethnomusicolo-gist Erich Moritz von Hornbostel. All three were united by a common scientific experimental training and a solid musical education, typical of their Bildungsbu
ü
rgertum. With them, Boas consistently shared his fieldwork findings regarding music, sound, and language among the Indians of British Columbia: indeed, their epistolary exchanges intertwine epistemological reflections centered on the study of «exotische Musik» in context with technical problems, derived from the use of phonographic recordings and the relative shipments of wax cylinders by Boas to the Phonographic Archive. So far, the critical literature has not paid particular attention to their correspondence, that offer instead a privileged look in observing the birth of Ethnomusicology, at the time still defined as comparative Musicology (vergleichende Musikwissenschaft). Starting from a biographical contextualization and following the micro-history of the scientific and personal relationship of these scientists, the contribution aims to explore the hypothesis that the emerging Ethnomusicology significantly contributed to the definition of Cultural Anthropology as a discipline. In his painstaking research devoted to the Native Indian sounds and languages, Boas observed indeed what happens if a mind is exposed to a new sound, musical or linguistic context; he had therefore to rigorously deal with the phenomena of mishearing, sound-blindness and biasing filter related to the perception of «new sounds». Thanks to his fieldwork, Boas would endorse a relativistic and “in context” approach to perception and mental representations of sounds, fostering his eventual lifelong, hectic concern about a broaden antiracist theory of human mental functions.
Monitoring the sensitivity of influenza viruses to oseltamivir, in Romania, from 2016 to 2023
Authors: Mihai Maria Elena , Ivanciuc Alina Elena , Cherciu Carmen Maria , Mihăescu Grigore , Lazăr Mihaela 
Published: May 2024

Abstract

Introduction: influenza is an acute viral disease caused by infection of the upper respiratory tract - difficult to control, which affects a large part of the population. Neuraminidase inhibitors (NAIs), such as oseltamivir and zanamivir, are the antiviral drugs utilized in Romania for the treatment of respiratory infections caused by the influenza viruses. The objective of the study is to monitor and analyze influenza viruses circulating in Romania, in terms of their susceptibility to oseltamivir, with the aim of signalling the emergence of viral strains resistant to antivirals.

Methods: The phenotypic method was performed to evaluate the inhibitory effect of oseltamivir on the neuraminidase enzyme activity of influenza viruses. Genotypic methods (SNP-based assays or sequencing of neuraminidase/whole genome) were used for detecting amino acid substitutions associated with influenza antiviral resistance. The study period is from 2016 to 2023.

Results: from the total number of influenza viruses isolated during the period (833 isolated), 670 strains were characterized antigenically and genetically, and the phenotypic susceptibility to antivirals was performed for 245 isolated viral strains. According to WHO criteria categories antiviral susceptibility based on IC50 data, none of the test results indicated reduced or highly reduced inhibition by oseltamivir.

Conclusion: This monitoring, carried out in the National Influenza Center Romania - Cantacuzino NMMIRD, is extremely important to maintain effective flu control and further development of other antiviral agents.
The New Paths of Environmental Management In Brazil: Reflections on Participatory Governance in the Environmental Permit Process
Authors: Silva Thaysa Sonale Almeida , Carneiro Ricardo , Brasil Flávia de Paula Duque 
Published: May 2024

Objective: The objective of this study is to investigate environmental management in Brazil, with the aim of recovering the trajectory of the legal landmarks that anchor it and highlight the regulatory proposals for licensing currently under discussion in the National Congress, which point in the direction of a greater flexibility of the process and greater rigor in the observance of deadlines, alongside the weakening of the role of public hearings.

Theoretical Reference: In this topic, the main concepts and theories that underpin the research are presented. Above all, the discussion on environmental governance is highlighted, which provides a solid basis for understanding the context of research.

Method: The methodology adopted for this research comprises a literature review on participatory governance and analysis of primary and secondary data. The data collection was carried out by means of documentary analysis.

Results and Discussion: The results obtained revealed the setback that is insinuated with the deconstruction of legal conquests that were supposed to be consolidated, which denotes a clear trend of reformulation of Brazilian environmental policy informed by the primacy of economic interests over the sustainable, and democratic, management of the environment. In the discussion section, these results are contextualized in the light of the theoretical benchmark, highlighting the implications and relationships identified. Possible discrepancies and limitations of the study are also considered in this section.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of environmental management in the country. These implications can cover the areas of sustainability, participatory management, socio-environmental justice, among others.

Originality/Value: This study contributes to the literature by critically addressing proposals for restructuring environmental licensing in the country. The relevance and value of this research is evidenced by helping to understand the trajectory of environmental legal milestones and the impacts that the proposed changes suggest.