bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of hippocampal long‐term potentiation and long‐term depression by diacylglycerol kinaseζ
Authors: Seo Jinsoo , Kim Karam , Jang Seil , Han Seungnam , Choi Se‐Young , Kim Eunjoon 
Published: November 2010

AbstractDiacylglycerol (DAG) is an important signaling molecule at neuronal synapses. Generation of synaptic DAG is triggered by the activation of diverse surface receptors including N‐methyl‐D‐aspartate (NMDA) receptors and metabotropic glutamate receptors. The action of DAG is terminated by enzymatic conversion of DAG to phosphatidic acid (PA) by DAG kinases (DGKs). DGKζ, one of many mammalian DGKs, is localized to synapses through direct interaction with the postsynaptic scaffolding protein PSD‐95, and regulates dendritic spine maintenance by promoting DAG‐to‐PA conversion. However, a role for DGKζ in the regulation of synaptic plasticity has not been explored. We report here that Schaffer collateral‐CA1 pyramidal synapses in the hippocampus of DGKζ‐knockout (DGKζ−/−) mice show enhanced long‐term potentiation (LTP) and attenuated long‐term depression (LTD). The attenuated LTD at DGKζ−/− synapses involves both NMDA receptors and metabotropic glutamate receptors. These changes in LTP and LTD were reversed by phospholipase C inhibition, which blocks DAG production. Similar reversals in both LTP and LTD were also induced by inhibition of protein kinase C, which acts downstream of DAG. These results suggest that DGKζ regulates hippocampal LTP and LTD by promoting DAG‐to‐PA conversion, and establish that phospholipase C and protein kinase C lie upstream and downstream, respectively, of DGKζ‐dependent regulation of hippocampal LTP and LTD. © 2010 Wiley Periodicals, Inc.
Trends in rainfall and runoff in the Blue Nile Basin: 1964–2003
Authors: Tesemma Zelalem K. , Mohamed Yasir A. , Steenhuis Tammo S. 
Published: November 2010

AbstractMost of the water from the Nile originates in Ethiopia but there is no agreement on how land degradation or climate change affects the future flow in downstream countries. The objective of this paper is to improve the understanding of future conditions by analysing historical trends. During the period 1964–2003, the average monthly basin‐wide precipitation and monthly discharge data were collected and analysed statistically for two stations in the upper 30% of the Blue Nile Basin and monthly and 10‐day discharge data of one station at the Sudan–Ethiopia border. A rainfall–runoff model examined the causes for observed trends. The results show that, while there was no significant trend in the seasonal and annual basin‐wide average rainfall, significant increases in discharge during the long rainy season (June to September) were observed at all three stations. In the upper Blue Nile, the short rainy season flow (March to May) increased, while the dry season flow (October to February) stayed the same. At the Sudan border, the dry season flow decreased significantly with no change in the short rainy season flow. The difference in response was likely due to the construction of weir in the 1990s at the Lake Tana outlet that affected the upper Blue Nile discharge significantly but affected less than 10% of the discharge at the Sudan border. The rainfall–runoff model reproduced the observed trends, assuming that an additional 10% of the hillsides were eroded in the 40‐year time span and generated overland flow instead of interflow and base flow. Models concerning future trends in the Nile cannot assume that the landscape runoff processes will remain static. Copyright © 2010 John Wiley & Sons, Ltd.
Low‐income parents' warmth and parent–child activities for children with disabilities, suspected delays and biological risks
Authors: Eshbaugh Elaine M. , Peterson Carla A. , Wall Shavaun , Carta Judith J. , Luze Gayle , Swanson Mark , Jeon Hyun‐Joo 
Published: November 2010

AbstractWarm and responsive parenting is optimal for child development, but this style of parenting may be difficult for some parents to achieve. This study examines how parents' observed warmth and their reported frequency of parent–child activities were related to children's classifications as having biological risks or a range of disability indicators. Children were low‐income prekindergarteners who participated in the Early Head Start Research and Evaluation Project Longitudinal Follow‐up. Data from parent, early care and education staff reports, and direct child assessments were used to classify children into the following groups: disabilities, suspected delays, biological risks, disabilities and biological risk, suspected delays and biological risk, and no disability indicator. Socioeconomic status (ethnicity, maternal education and poverty level) and maternal depression were controlled in the analyses. The parents of children with disabilities and suspected delays evidenced significantly lower levels of warmth and less frequent parent–child activities compared with other parents. The parents of children with biological risk factors who did not also have disabilities or suspected delays did not exhibit decreased warmth and less frequent parent–child activities. Copyright © 2010 John Wiley & Sons, Ltd.
Modification of proteins secreted by endothelial cells during modeled low gravity exposure
Authors: Griffoni Cristiana , Di Molfetta Serena , Fantozzi Luca , Zanetti Cristiana , Pippia Proto , Tomasi Vittorio , Spisni Enzo 
Published: November 2010

AbstractThe exposure of the human body to microgravity, conditions that occurs during space flights, causes significant changes in the cardiovascular system. Many cell types have been involved in these changes, and the endothelium seems to play a major role. In endothelial cells (EC), it has been shown that modeled low gravity impairs nitric oxide synthesis, cell adhesion, extracellular matrix composition, cytoskeleton organization, cytokines, and growth factors secretion. Nevertheless, detailed analysis of EC physiological changes induced by microgravity exposure is still lacking. Secretome analysis is one of the most promising approaches for the identification of biomarkers directly related to the physiopathological cellular state. In this study, we analyzed in details the modifications of EC secretome by using umbilical vein endothelial (HUVE) cells exposed to modeled low gravity conditions. By adopting a two‐dimensional (2‐D) proteomic approach, in conjunction with a technique for the compression of the dynamic range of proteins, we observed that modeled low gravity exposure of HUVE cells affected the secretion of proteins involved in the regulation of cytoskeleton assembly. Moreover, by using Luminex® suspension array systems, we found that the low gravity condition decreased in ECs the secretion of some key pro‐inflammatory cytokines, including IL‐1α and IL‐8, and of the pro‐angiogenic factor bFGF. On the contrary, microgravity increase the secretion of two chemokines (Rantes and Eotaxin), involved in leukocytes recruitment. J. Cell. Biochem. 112: 265–272, 2011. © 2010 Wiley‐Liss, Inc.
Activating transcription factor 2 targets c‐Fos, but not c‐Jun, in growth plate chondrocytes
Authors: Li Xinying , LuValle Phyllis 
Published: November 2010

AbstractActivating transcription factor 2 (ATF‐2), c‐Fos, and c‐Jun belong to the bZIP family of transcription factors. Promoters of c‐Fos, c‐Jun, cyclin D1, and cyclin A are targets of ATF‐2 in primary mouse chondrocytes. An ATF‐2 expression vector was co‐transfected with either c‐Fos or c‐Jun promoters in mutant ATF‐2 chondrocytes in order to show by luciferase assay that ATF‐2 increased promoter activity of c‐Fos, but not c‐Jun. Chromatin immunoprecipitation (ChIP) assays revealed that ATF‐2 bound with the c‐Fos promoter at the −294 cyclic AMP response element (CRE) site, but did not bind to the TPA responsive element (TRE) or activating protein‐1 (AP1) sites of the c‐Jun promoter. Dominant‐negative (dn) c‐Fos inhibited cyclin D1 promoter activity. However, dn c‐Jun had minimal effect on this same promoter activity. c‐Fos was capable of interactions with both the cyclin D1 CRE and AP1 sites, while c‐Jun co‐operated specifically with the cyclin D1 CRE site. Neither c‐Fos nor c‐Jun had any effect on cyclin A promoter activity. c‐Fos was unable to bind to the cyclin A AP1 or CRE sites. In contrast c‐Jun was competent in interactions with cyclin A AP1‐2 as well as the CRE. J. Cell. Biochem. 112: 211–216, 2011. © 2010 Wiley‐Liss, Inc.
Parthenolide sensitizes hepatocellular carcinoma cells to trail by inducing the expression of death receptors through inhibition of STAT3 activation
Authors: Carlisi Daniela , D'Anneo Antonella , Angileri Liliana , Lauricella Marianna , Emanuele Sonia , Santulli Andrea , Vento Renza , Tesoriere Giovanni 
Published: November 2010

AbstractThis article shows that HepG2, Hep3B, and SK‐Hep1 cells, three lines of human hepatocellular carcinoma (HCC) cells, are resistant to apoptosis induced by tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL). Parthenolide, a sesquiterpene lactone found in European feverfew, has been shown to exert both anti‐inflammatory and anti‐cancer activities. This article demonstrates that co‐treatment with parthenolide and TRAIL‐induced apoptosis with synergistic interactions in the three lines of HCC cells. In order to explain these effects we ascertained that parthenolide increased either at protein or mRNA level the total content of death receptors TRAIL‐R1 and ‐R2 as well as their surface expression. These effects were found in the three cell lines in the case of TRAIL‐R2, while for TRAIL‐R1 they were observed in HepG2 and SK‐Hep1 cells, but not in Hep3B cells. We suggest that the effects of parthenolide on death receptors depend on the decrease in the level of phosphorylated and active forms of STAT proteins, an event which could be a consequence of the inhibitory effect exerted by parthenolide on the activation of JAK proteins. In agreement with this hypothesis treatment with STAT3 siRNA increased in HCC cells the effect of parthenolide on the expression of death receptors. Sensitization by parthenolide to TRAIL stimulated in the three cell lines the extrinsic mechanism of apoptosis with the activation of both caspases 8 and 3, whereas mitochondria were not involved in the process. Our results suggest that co‐treatment with parthenolide and TRAIL could represent a new important therapeutic strategy for hepatic tumors. J. Cell. Physiol. 226: 1632–1641, 2011. © 2010 Wiley‐Liss, Inc.
High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BKCa channel
Authors: Chang Hui , Ma Yu‐Guang , Wang Yun‐Ying , Song Zhen , Li Quan , Yang Ning , Zhao Hua‐Zhou , Feng Han‐Zhong , Chang Yao‐Ming , Ma Jin , Yu Zhi‐Bin , Xie Man‐Jiang 
Published: November 2010

AbstractIt has been reported that diabetic vascular dysfunction is associated with impaired function of large conductance Ca2+‐activated K+ (BKCa) channels. However, it is unclear whether impaired BKCa channel directly participates in regulating diabetic vascular remodeling by altering cell growth in response to hyperglycemia. In the present study, we investigated the specific role of BKCa channel in controlling apoptosis and proliferation under high glucose concentration (25 mM). The cDNA encoding the α+β1 subunit of BKCa channel, hSloα+β1, was transiently transfected into human embryonic kidney 293 (HEK293) cells. Cloned BKCa currents were recorded by both whole‐cell and cell‐attached patch clamp techniques. Cell apoptosis was assessed with immunocytochemistry and analysis of fragmented DNA by agarose gel electrophoresis. Cell proliferation was investigated by flow cytometry assays, MTT test, and immunocytochemistry. In addition, the expression of anti‐apoptotic protein Bcl‐2, intracellular Ca2+, and mitochondrial membrane potential (Δψm) were also examined to investigate the possible mechanisms. Our results indicate that inhibition of cloned BKCa channels might be responsible for hyperglycemia‐altered apoptosis and proliferation in HEK‐hSloα+β1 cells. However, activation of BKCa channel by NS1619 or Tamoxifen significantly induced apoptosis and suppressed proliferation in HEK‐hSloα+β1 cells under hyperglycemia condition. When rat cerebral smooth muscle cells were cultured in hyperglycemia, similar findings were observed. Moreover, the possible mechanisms underlying the activation of BKCa channel were associated with decreased expression of Bcl‐2, elevation of intracellular Ca2+, and a concomitant depolarization of Δψm in HEK‐hSloα+β1 cells. In conclusion, cloned BKCa channel directly regulated apoptosis and proliferation of HEK293 cell under hyperglycemia condition. J. Cell. Physiol. 226: 1660–1675, 2011. © 2010 Wiley‐Liss, Inc.
Ultrasound‐guided gadolinium joint injections for magnetic resonance arthrography
Authors: Choudur Hema Nalini , Ellins Mary Lou 
Published: November 2010

AbstractPurposeTo determine the feasibility and accuracy of ultrasound (US) ‐guided gadolinium injection for MR arthrography of shoulders, wrists, hips, and knee joints as an alternate technique to fluoroscopy.MethodsOne hundred patients referred to our center for an MR arthrogram of shoulders, wrists, hips, and knees were included in the study. There were 53 males and 47 females and ages ranged from 17 to 63 years (mean age, 37). US was used to guide the needle tip into the joint. The intra‐articular location of the needle tip was confirmed by fluoroscopic visualization of injected iodinated contrast medium, prior to gadolinium injection. The patients then proceeded for the MRI examination.ResultsNinety‐nine of the 100 patients were successfully injected with gadolinium under US guidance. One patient had a vasovagal reaction after local anesthetic injection and the procedure was aborted.ConclusionUS is an effective alternate guidance technique for the injection of gadolinium into shoulder, hip, knee, and wrist joints for MR arthrography. Its advantages are cost effectiveness, ease of performance, and lack of radiation. © 2010 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Sonographic features of intravascular papillary endothelial hyperplasia (Masson's tumor) in the forearm
Authors: Lysyy Oleg , Schwartz Ignat , Kolander Yehuda , Strauss Simon 
Published: November 2010

AbstractIntravascular papillary endothelial hyperplasia, also known as Masson's tumor, is a benign, vascular lesion in which there is papillary proliferation of endothelial cells. The lesion presents as a palpable soft‐tissue mass, often located within normal or dilated vascular spaces, and may be mistaken for a sarcomatous tumor on imaging. We present the case of an intravascular papillary endothelial hyperplasia in the forearm, with a remarkable appearance on color Doppler sonography, and suggest that this entity will be encountered more frequently by sonologists in the future. © 2010 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Prevalence and disease burden of primary restless legs syndrome: Results of a general population survey in the United States
Authors: Allen Richard P. , Bharmal Murtuza , Calloway Michael 
Published: November 2010

AbstractTo assess prevalence, disease burden, and costs of primary Restless Legs Syndrome (RLS) in the US. In 2007, 61,792 (20%) of 313,000 subjects from a representative US panel completed an online “global opinions” survey identifying respondents reporting all four diagnostic features of RLS. 4,484 met all criteria. 1,400 were randomly selected to complete a questionnaire to exclude those with diagnoses indicating possible secondary RLS. Those that did not have diagnoses associated with secondary RLS were asked to complete the Cambridge‐Hopkins RLS questionnaire to exclude RLS mimics. Prevalence was estimated for the following groups: (1) RLS symptomatic, (2) primary RLS, and (3) primary RLS sufferers (symptoms ≥2/wk with moderate‐to‐severe distress). The primary RLS completed a larger online survey including the IRLS, EuroQol, Work Productivity and Activity Impairment questionnaire, and questions about healthcare resource use. The validated diagnostic tools and exclusion of medical conditions likely to cause RLS provide a very conservative estimate of US census‐weighted prevalence of 2.4% for primary RLS and 1.5% for primary RLS sufferers. About 33% of respondents had a physician diagnosis of RLS. Primary RLS sufferers had a mean productivity loss of 1 day/wk. All RLS‐related costs increased with RLS symptom severity, with increasingly significant decrements in health status, sleep disturbance, and work productivity. Even this very conservative approach finds RLS in this cohort to be common, under‐diagnosed, and carried a significant personal and social burden. © 2010 Movement Disorder Society
Clinical correlates of quality of life in Tourette syndrome
Authors: Eddy Clare M. , Cavanna Andrea E. , Gulisano Mariangela , Agodi Antonella , Barchitta Martina , Calì Paola , Robertson Mary M. , Rizzo Renata 
Published: November 2010

AbstractTourette syndrome (TS) is a neurodevelopmental disorder involving tics, which is frequently accompanied by comorbid obsessive compulsive (OCD) or attention deficit hyperactivity disorder (ADHD). Individuals with TS often report poor quality of life (QoL) in comparison with the general population. This study investigated the clinical correlates of QoL in young people with TS using a self‐report multidimensional QoL measure, and a range of clinical scales used to assess tic severity and the symptoms of anxiety, depression, OCD, ADHD and other emotional and behavioral symptoms. Symptoms of depression, OCD, and ADHD appeared to have a widespread negative impact on QoL, but poorer QoL was not associated with increased tic severity. Greater emotional and behavioral difficulties, including symptoms of OCD, were among the best predictors of poor QoL in young people with TS. © 2010 Movement Disorder Society
Regulating Australia's lobbyists: coming full circle to promote democracy?
Authors: Hogan John , Chari Raj , Murphy Gary 
Published: November 2010

Abstract

This paper initially examines the history and evolution of lobbying regulations in Australia at both the federal and state levels. This examination is conducted in a comparative context, setting the codes of conduct in place in various Australian jurisdictions against each other, as well as against the lobbying regulations in place in other countries around the world. Based upon this approach, the regulations in each Australian jurisdiction are classified according to their characteristics, providing insights into their commonalities and differences. Thereafter, we examine the attitudes of Australian politicians, administrators and lobbyists, at both the federal and state levels, towards the regulations they have to abide by.
Copyright © 2010 John Wiley & Sons, Ltd.
Ultrasound probe pressure but not maternal Valsalva maneuver alters Doppler parameters during fetal middle cerebral artery Doppler ultrasonography
Authors: Su Yi‐Ming , Lv Guo‐Rong , Chen Xiao‐Kang , Li Shao‐Hui , Lin Hui‐Tong 
Published: November 2010

AbstractObjectiveTo determine the effects of increased ultrasound probe pressure and maternal Valsalva maneuver (VM) on the middle cerebral artery (MCA) Doppler ultrasonography in fetuses.MethodsA total of 120 healthy pregnant women in second and third trimesters were enrolled in the study. MCA blood flow was measured by pulsed Doppler sonography in 60 fetuses (24 and 40 weeks' gestation) before and after the application of increased ultrasound probe pressure. In the other 60 fetuses (32 and 36 weeks' gestation), sonography was performed before and after maternal VM. Statistical analysis was performed by pairedt‐test.ResultsThe pressure induced by the ultrasound probe induced a significant increase in the pulsatility index (PI), resistance index (RI), and peak systolic velocity (PSV); however, a significant decrease was found in the end‐diastolic velocity (EDV) (p< 0.05). No statistically significant difference was found in the mean flow velocity (MFV). Moreover, maternal VM did not have any effect on the PI, RI, EDV, or MFV.ConclusionFetal MCA Doppler assessment is affected by increased probe pressure but not by maternal VM. Thus, the application of the MCA Doppler sonography should be undertaken in the head of fetuses without any probe pressure and without maternal VM. Copyright © 2010 John Wiley & Sons, Ltd.
The phase transition and elastic property of osmium carbide under pressure
Authors: Peng Feng , Chen Dong , Fu Hongzhi , Gao Tao 
Published: November 2010

AbstractFirst‐principles calculations of the stabilities, the mechanical properties, and the elastic properties of osmium carbide (OsC) in tungsten carbide (WC) and nickel arsenide (NiAs) structures have been carried out with the plane‐wave pseudopotential density functional theory method. WC‐OsC is stable in the ground state. The phase‐transition pressure from WC structure to NiAs structure is about 7.2 GPa. The pressure dependence of the elastic constants, the aggregate elastic moduli (B, G and E), Poisson's ratio, the Lamè constants, the compressibility, and the elastic anisotropy of these two structures are calculated and compared; many differences can be found in the two structures.
Anticomplement activity of polyacetylenes from leaves of Dendropanax morbifera Leveille
Authors: Chung Ill‐Min , Song Hong‐Keun , Kim Sun‐Jin , Moon Hyung‐In 
Published: November 2010

AbstractThe present study evaluated the anticomplement effect of polyacetylenes from Dendropanax morbifera (Araliaceae) in the classical pathway complement system. The leaves of D. morbifera were evaluated with regard to its anticomplement activity, and its active principles identified following activity‐guided isolation. An aqueous CCl4 fraction of the leaves of D. morbifera exhibited significant anticomplement activity on the classical pathway complement system, which was expressed as total hemolytic activity. Three polyacetylenes isolated from the leaves of D. morbifera, namely (3S)‐falcarinol (1), (3S,8S)‐falcarindiol (2) and (3S)‐diynene (3). Compounds 1, 2 and 3 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC50) values of 87.3 µm, 15.2 µm and 39.8 µm. Among the compounds tested, 2 showed the most potent anticomplement activity (IC50, 15.2 µm). Copyright © 2010 John Wiley & Sons, Ltd.
The role of technical expertise in firm governance structure: evidence from chief financial officer contractual incentives
Authors: Gore Angela K. , Matsunaga Steve , Eric Yeung P. 
Published: November 2010

AbstractWe provide evidence that the presence of technical expertise in firm governance structure reduces reliance on contractual incentives to control the potential agency problem for executives whose responsibilities require specialized knowledge. Specifically, we find that firms with financial expertise in the form of a board finance committee, or a chief executive officer with a financial background, tend to use lower levels of incentive‐based compensation for their chief financial officers. Our findings suggest financial experts provide stronger oversight and/or direction with regard to firm financial policies and strategies, thereby allowing firms to reduce reliance on incentive compensation. Our study provides insight into the role of technical expertise and board committees in firm governance, and into the benefits of common functional expertise within top management teams. Copyright © 2010 John Wiley & Sons, Ltd.