bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Systemic Sclerosis Primary Heart Involvement and Chronic Heart Failure in the European Scleroderma Trials and Research Cohort
Authors: Györfi Andrea‐Hermina , Filla Tim , Polzin Amin , Tascilar Koray , Buch Maya , Tröbs Monique , Matei Alexandru‐Emil , Airo Paolo , Balbir‐Gurman Alexandra , Kuwert Frederic , Mihai Carina , Kabala Anna , Graßhoff Hanna , Callaghan Julia , Isomura Yohei , Mansour Jennifer , Spierings Julia , Tennoe Anders Heiervang , Selvi Enrico , Riccieri Valeria , Hoffmann‐Vold Anna‐Maria , Bergmann Christina , Schett Georg , Hunzelmann Nicolas , van Laar Jacob M. , Saketkoo Lesley Ann , Kuwana Masataka , Siegert Elise , Riemekasten Gabriela , Distler Oliver , du Four Tessa , Smith Vanessa , Truchetet Marie‐Elise , Distler Jörg H. W. ,   EUSTAR collaborators
Published: February 2025

Background
Systemic sclerosis (SSc) primary heart involvement (SSc‐pHI) is one of the leading causes of mortality in SSc. We aimed to evaluate risk factors for SSc‐pHI and its progression and the outcomes in the EUSTAR (European Scleroderma Trials and Research) cohort.

Methods
SSc‐pHI was defined according to the World Scleroderma Foundation/Heart Failure Association definition. Data from 5741 patients with SSc in the EUSTAR cohort were analyzed. Additional cardiovascular data were collected from a subcohort of 838 patients with SSc. Lasso regression was used for risk factor analyses. Kaplan–Meier estimator was used for survival analyses. Progression of SSc‐pHI was evaluated by a study definition developed by rheumatology and cardiology experts.

Results

Risk factors for the presence of SSc‐pHI comprised skeletal muscle atrophy (odds ratio [OR], 2.00 [95% CI, 1.00–2.68]), age (OR, 1.91 [95% CI, 1.73–2.03]), male sex (OR, 1.77 [95% CI, 1.42–2.05]), swollen joints (OR, 1.70 [95% CI, 1.47–1.98]), skeletal muscle weakness (OR, 1.38 [95% CI, 1.00–1.85]), and tendon friction rubs (OR, 1.46 [95% CI, 1.00–1.77]) (n=3276). Telangiectasia (OR, 2.10 [95% CI, 1.38–2.72]), intestinal symptoms (OR, 1.70 [95% CI, 1.04–2.42]), age (OR, 1.47 [95% CI, 1.21–1.62]), and antitopoisomerase I antibodies (OR, 1.37 [95% CI, 1.00–1.77]) were associated with an increased risk for new onset of SSc‐pHI (n=1000). Survival rate was significantly lower in patients with SSc‐pHI than in those without (
P
value <0.0001, n=3768). Patients with SSc‐pHI had a lower survival rate than patients with interstitial lung disease (n=3365). Swollen joints were associated with an increased risk of progressive SSc‐pHI (OR, 2.49 [95% CI, 1.79–3.52]) (n=595). Tendon friction rubs (OR, 1.21 [95% CI, 0.94–1.90]) increased the risk of heart failure with preserved ejection fraction in patients with SSc‐pHI.

Conclusions
We defined progressive SSc‐pHI and identified risk factors for new onset and progression of SSc‐pHI and for SSc‐pHI‐associated heart failure with preserved ejection fraction in the largest cohort with SSc. These findings may guide patient stratification for diagnostic workup and therapy.
Extracellular Matrix Proteins Improve Risk Prediction in Patients Undergoing Transcatheter Aortic Valve Replacement
Authors: Boeckling Felicitas , Rasper Tina , Zanders Lukas , Pergola Graziella , Cremer Sebastian , Mas‐Peiro Silvia , Vasa‐Nicotera Mariuca , Leistner David , Dimmeler Stefanie , Kattih Badder 
Published: February 2025

Background
Cardiac fibrosis is common in patients with severe aortic stenosis and an independent predictor of death. Therefore, we examined the additional value of circulating fibrosis markers as a putative biomarker platform to identify patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) who are at a higher risk of death.

Methods
In this study, 2‐year survival analyses were conducted in 378 consecutive patients undergoing TAVR to evaluate the association between fibrosis marker and risk of adverse long‐term outcome. Implementation of fibrosis marker into TAVR risk stratification was tested by a machine‐learning algorithm.

Results

Among 20 circulating fibrosis markers involved in pathological extracellular matrix remodeling, high tissue inhibitor of metalloproteinase‐1 (TIMP‐1) levels independently predicted risk of death in univariable (hazard ratio, 5.0 [95% CI, 2.6–9.7];
P
<0.001) and multivariable (adjusted hazard ratio, 2.2 [95% CI, 1.0–4.7];
P
=0.046) Cox regression analyses. Consequently, higher TIMP‐1 levels offered a significantly higher overall prediction of reduced survival compared with the conventional Society of Thoracic Surgeons Predicted Risk of Mortality score (area under the curve, 0.753 [95% CI, 0.682–0.824] versus area under the curve, 0.656 [95% CI, 0.578–0.734];
P
<0.05). Applying an independent machine‐learning algorithm allowed identification of a simple combination of 2 biomarkers (TIMP‐1 and high‐sensitivity cardiac troponin T) with superior prognostic value compared with Society of Thoracic Surgeons Predicted Risk of Mortality alone (area under the curve, 0.757 [95% CI, 0.686–0.828] versus 0.656 [95% CI, 0.578–0.34];
P
<0.05).

Conclusions
Circulating TIMP‐1 is an independent predictor of reduced 2‐year overall survival in patients undergoing TAVR. Combined with high‐sensitivity cardiac troponin T, circulating TIMP‐1 should be incorporated into risk stratification to identify patients undergoing TAVR who are at a higher risk of death.
Nicotinamide Riboside: A Promising Treatment for Type 1 Cardiorenal Syndrome in Myocardial Infarction‐Induced Acute Kidney Injury by Upregulating Nicotinamide Phosphoribosyltransferase‐Mediated Nicotinamide Dinucleotide Levels
Authors: Habeichi Nada J. , Amin Ghadir , Boitard Solene , Tannous Cynthia , Ghali Rana , Momken Iman , Diab Reine , Booz George W. , Mericskay Mathias , Zouein Fouad A. 
Published: February 2025

Background

Cardiorenal syndrome type 1 is characterized by the development of acute kidney injury following acute cardiac illness and notably acute myocardial infarction (MI). Acute kidney injury is considered an independent risk factor that increases mortality rate substantially. Nicotinamide adenine dinucleotide (NAD) is an important coenzyme in energy metabolism and oxidative phosphorylation, and in its oxidized form it is a substrate for multiple NAD
+
‐dependent enzymes such as sirtuins and poly‐ADP ribose polymerases. Decreased cardiac NAD levels, along with a downregulation of NAMPT (nicotinamide phosphoribosyl transferase), have been reported following MI. A compensatory upregulation in NMRK (nicotinamide riboside kinase) 2, an NAD
+
biosynthetic enzyme that uses nicotinamide riboside (NR) to generate NAD
+
, takes place in the heart after MI, but the impact on kidney NAD metabolism and function has not been addressed before.

Methods and Results
MI was induced by ligating the left anterior descending coronary artery in 2‐month‐old C57BL6/J mice, followed by the administration of NR (IP injection, 400 mg/kg per day) for 4 and 7 days. We hypothesized that NR treatment could be a potentially promising therapy for MI‐induced acute kidney injury. Our findings showed no significant improvement in cardiac ejection fraction following NR treatment at days 4 and 7 post‐MI, whereas kidney functions were enhanced and morphological alterations and cell death decreased. The observed renal protection seems to be mediated by an upregulation of NAMPT‐mediated increase in renal NAD levels, notably in the distal tubules.

Conclusions
Our findings indicate that NR could potentially be a promising therapy for acute kidney injury following an early stage of MI.
Molecular identification and expression pattern of three novel Aurora kinases in Macrobrachium rosenbergii (Decapoda, Caridea)
Authors: Ma Wen-Ming , Luo Jing-Yu , Xu Yu-Li 
Published: February 2025

Abstract
Aurora kinase is crucial in mitosis and meiosis. Three novel Aurora kinases were identified in Macrobrachium rosenbergii in the present study. There was a highly conserved serine/threonine domain within their C-terminal. Multiple sequence alignment of the serine/threonine domain in Mr-Aurora kinases revealed a high degree of similarity to other representative Aurora kinases. The phylogenetic analysis illustrated that Mr-Aurora A was clustered into a separate branch with the Aurora kinases of Armadillidium nasatum, and Mr-Aurora CA and Mr-Aurora CB were clustered together in a separate branch. Additionally, both Mr-Aurora A and Mr-Aurora CA genes were specifically expressed in the reproductive system. But, Mr-Aurora CB was expressed in a multi-tissue pattern. Furthermore, all Mr-Aurora kinases were expressed throughout embryonic development and showed various levels of expression in different periods. This study can possibly provide a novel highlight to the molecular mechanism of Aurora kinases’ involvement in cell division of reproduction and embryonic development of crustaceans.
Use of shell colour to infer colour and carotenoid content of the hepatopancreas of the giant river prawn, Macrobrachium rosenbergii (De Man, 1879) (Decapoda, Caridea, Palaemonidae)
Authors: Liu Junhui , Lu Qifeng , Zhang Huai , Wei Yong , Lin Li , Li Qingqing 
Published: February 2025

Abstract
Colour affects the quality and market price of crustaceans, and crustaceans with different hues vary in popularity. However, it is difficult to observe the colour of the internal tissues of live crustaceans with the naked eye. In this study, cooked shells of brown red and dark blue Macrobrachium rosenbergii (De Man, 1879) exhibited higher a*, for redness (20.66 ± 0.34 and 19.25 ± 0.38 vs. 16.82 ± 0.28) and b*, for yellowness (23.39 ± 0.50 and 23.61 ± 0.43 vs. 20.53 ± 0.31) values compared to those of light yellow M. rosenbergii, and the astaxanthin content of the shell showed a similar trend. Blue pigment cells are abundant in dark blue M. rosenbergii, whereas pigment cell development is restricted in light yellow specimens. In brown red individuals, both blue and red pigment cells are abundant. We detected a significant, positive correlation between the a* value of the raw shell and the b* value of the cooked hepatopancreas (, ); between the a* value of the raw shell and the α-carotene content in the shell (, ) and β-carotene content in the shell (, ); and between the b* value of the shell and the astaxanthin content of the hepatopancreas (, ). The a* (, ) and b* (, ) values of the cooked shell also were significantly correlated with astaxanthin content. These results contribute to a more comprehensive understanding of the relationship between shell colour and hepatopancreas coloration and carotenoid content, and they show that the colour of the hepatopancreas can be inferred from the shell colour of M. rosenbergii.
On Another Beginning: Thinking in the Anthropocene
Authors: Moreiras Alberto 
Published: February 2025

Abstract
This essay rehearses the notion that exiting the Anthropocene has as a condition leaving behind metaphysics as the dominant mode of thought. It dwells on Reiner Schürmann’s idea of the anarchic practical subject as the subject of antiphilosophy, and it posits antiphilosophy as the locus for a possible meontological thinking of another beginning, using the Heideggerian theme. It examines positions such as Bernard Stiegler’s and Jean-Luc Nancy’s on the possibility of an affirmative nihilism and considers Martin Heidegger’s determination of the “first inception” of philosophy in the West in the work of Heraclitus and Parmenides. It belabors infrapolitics as the pain or dis-turbance of the loss of the politics of modernity as a productive possibility. And it calls for a militant and belligerent practice of anarchic and antihybristic thought in our present.
‘Arriving in Strange Places’
Authors: Gulddal Jesper 
Published: February 2025

Abstract
This article explores the status and functionality of passport and border control practices in contemporary migration literature, analysing such interfacing with the global passport regime as a “chronotope of movement control”. As a first step, it outlines the history of this chronotope and shows how movement control practices have impacted on the genre of the novel in various ways at least since the mid-eighteenth century. Having established this historical context, the article goes on to analyse the representation and narrative utilisation of passports and borders in five migration novels, each focusing on a different continental setting and different border hot spot: Abdulrazak Gurnah’s By the Sea (2001), T.C. Boyle’s The Tortilla Curtain (1995), Herta Müller’s Der Mensch ist ein grosser Fasan auf der Welt (1986), Tahar Ben Jelloun’s Partir (2006) and Behrouz Boochani’s No Friend but the Mountains (2017). By way of conclusion, the article discusses how the chronotope of movement control establishes a link between migration literature and world literature – not only because it has become a staple of migration literature worldwide, but also because it highlights questions of exclusion, access and cross-border circulation that are central to both forms of literature.
Exophonic Literature in Japanese as New World Literature
Authors: Hein Ina 
Published: February 2025

Abstract
The dominant notion that modern Japanese literature is a national literature – written (only) by ethnic Japanese, whose mother tongue is Japanese, in the Japanese language, for a Japanese reading audience – is recently challenged by writers who are non-native speakers of Japanese, having been born and raised outside of Japan, and, after having migrated to Japan, deliberately chose Japanese as their literary language, thus becoming authors of literature in Japanese. This article shows how these writers decenter the Japanese language, Japanese literature, and ultimately ‘Japaneseness’ as such – on the plot-level of their texts as well as by stylistic and linguistic means. I argue that this kind of literature aims at de-nationalizing the understanding of ‘Japanese literature’, and in that sense can and should be read as new world literature.
كرسي محمود الغول لدراسات جزيرة العرب والكتابات ومساهمته في دراسة الكتابات القديمة في الأردن
Authors: الغول عمر 
Published: February 2025

الملخص
‫يتخذ هذا المقال من إعادة تنشيط كرسي محمود الغول لدراسات جزيرة العرب والكتابات، المُوطَّن بكلية الآثار والأنثروبولوجيا بجامعة اليرموك، منطلقًا لاستعراض تاريخ دراسة الكتابات في الأردن، العربية الشمالية القديمة خاصة. فيبدأ بضرب أمثلة على اشتغال الباحثين الغربيين بدراسة النقوش الصفوية والحسمائية منذ القرن التاسع عشر وحتى نهاية السبعينات من القرن العشرين. لينتقل بعدها إلى الحديث عن الوحدات البحثية والتدريسية التي تأسست بجامعة اليرموك لدراسة الكتابات القديمة في الأردن، وخاصة مشروع “مدونة نقوش الأردن”، وكرسي محمود الغول، وقسم النقوش. ويستعرض المقال مشاريع الكرسي المستقبلية، بما فيها إعادة إحياء مشروع “المدونة” التي ستعمل على نشر آلاف الكتابات العربية الشمالية المتوافرة في حوزة الكرسي، والتي تشمل أيضًا دعم النشر العلمي في الكتابات القديمة، وتعزيز التعاون مع المؤسسات العربية والدولية المشتغلة بهذا المجال.‬
The Epigraphy of the Tribe of ʿĀd
Authors: Al-Jallad Ahmad 
Published: February 2025

Abstract
This article surveys the pre-Islamic Arabian inscriptions produced by the tribe of ʿĀd, introducing a hitherto unpublished Safaitic text by an ʿĀdite. We demonstrate that a southern Arabian origin for this group is not supported by the epigraphic evidence; rather, the territory of ʿĀd appears to have spanned at least from the region of Wādī Ram (ancient ʾIram) in what is today southern Jordan to the Ḥarrah in the northeast. The group inhabited this country around the turn of the era, some two-thousand years ago. The article concludes with a discussion of Quran 53:50 and 89:6 in light of the archaeological and epigraphic evidence.
Annual Cycle Changes in the Vertical Structure of Ocean Temperature: A Fingerprint of Human Influence on Climate
Authors: Shi Jia-Rui , Santer Benjamin D. , Kwon Young-Oh , Wijffels Susan E. 
Published: February 2025

Abstract
We investigate changes in the vertical structure of the ocean temperature annual cycle amplitude (TEMPAC) down to a depth of 300 meters, providing important insights into the relative contributions of anthropogenic and natural influences. Using observations and CMIP6 model simulations, we perform a detection and attribution analysis by applying a standard pattern-based “fingerprint” method to zonal-mean TEMPAC anomalies for three major ocean basins. In all model historical simulations and observational datasets, TEMPAC increases significantly in the surface layer, except in the Southern Ocean, and weakens within the subsurface ocean. There is a decrease in TEMPAC below the annual-mean mixed layer depth, mainly due to a deep-reaching winter warming signal. The temporal evolution of signal-to-noise (S/N) ratios in observations indicates an identifiable anthropogenic fingerprint in both surface and interior ocean annual temperature cycles. These findings are consistent across three different observational datasets, with variations in fingerprint detection time likely related to differences in dataset coverage, interpolation method, and accuracy. Analysis of CMIP6 single-forcing simulations reveals the dominant influence of greenhouse gases and anthropogenic aerosols on TEMPAC changes. Our identification of an anthropogenic TEMPAC fingerprint is robust to the selection of different analysis periods. S/N ratios derived with model data only are consistently larger than ratios calculated with observational signals, primarily due to model-versus-observed TEMPAC differences in the Atlantic. Human influence on the seasonality of surface and subsurface ocean temperature may have profound consequences for fisheries, marine ecosystems, and ocean chemistry.
Physical characterization of PEGylated exosome constructs: Size, charge, and morphology changes in non-specific alkylating N-terminal reactions
Authors: Martínez-Santillán Andrés , González-Valdez José 
Published: February 2025

Small extracellular vesicles, commonly referred to as exosomes, withhold a promising future in the pharmaceutical industry as carriers for targeted drug delivery due to their high specificity and bioavailability when compared to synthetic-based vectors. They, however, present some limitations for systematic administration because of natural organism defenses and their high-water solubility, ultimately making it difficult for them to reach the intended target. To improve the delivery capacity of these nanoparticles, the possibility for the construction of PEGylated versions was explored in this work. This process was performed, analyzed, and characterized using N-terminal specific PEGylation reactions targeted to the protein contents in the exosomal membrane. For this, two different mono-methoxy polyethylene glycols (mPEG) of 5 and 20 kDa were reacted with exosomes under alkylating conditions. The resulting 5k and 20k PEGylated exosome constructs were characterized and compared with unmodified exosomes, using size, morphology, and zeta potential as comparison parameters. Results after analysis showed an absorbance reduction of approximately 65% and 34% (for the 5 and 20 kDa conjugates respectively), a reduction of 10 to 20% in peak resolution, particle size increase corresponding to the polymer sizes used, and a slight reduction in electric distribution of about 2 to 3 mV less than the unmodified vesicles. The data obtained may provide insights for the optimization of exosome PEGylation strategies for therapeutic use.
Clinical decision system for chronic kidney disease staging using machine learning
Authors: Chandralekha E. , Saravanan T. R. , Vijayaraj N. 
Published: February 2025

Background Chronic Kidney Disease (CKD) is a prevalent health condition that requires personalized treatment planning at each of its five stages. Machine Learning (ML) and Generative AI have shown promise in predicting CKD progression based on patient data. However, existing prediction models have limitations on generalizability, interpretability, and resource requirements. Objective This study aims to develop a clinical support system using ML models to classify CKD stages accurately. The research focuses on feature selection strategies and model performance evaluation to enhance prediction accuracy and guide personalized treatment planning for CKD patients. Methods The study utilizes ML algorithms, including Gradient Boosting, XGBoost, CatBoost, and GAN AML, to categorize CKD stages. Various feature selection techniques such as Recursive Feature Elimination, chi-square test, and SHAP are employed to identify relevant features for improved prediction accuracy. The models are evaluated based on precision, recall, F1-score, accuracy, and AUC-ROC metrics. Conclusions The findings demonstrate the effectiveness of CatBoost and GAN AML in accurately classifying CKD stages, highlighting the importance of expert knowledge in selecting feature selection strategies to enhance ML model performance. Future research directions include validating diverse datasets, integrating with clinical practice, and improving interpretability and explainability in CKD prediction models.
Relationship of influenza virus to inflammatory factors and immune function in elderly patients with COPD: A retrospective analysis
Authors: Chen Yanrong , Shi Yun , Dou Liyang , Liu Yan , Zhang Jing 
Published: February 2025

Objective The aim of this retrospective study was to investigate the relevance of influenza A virus (IAV) in acutely exacerbating airway inflammatory response and disrupting immune function in elderly COPD patients. Methods The group conducted a pre-test: using multiplex combined real-time PCR detection kits Multiple real⁃time PCR was used to detect twenty-four pathogens, 385 patients clinically diagnosed with COPD were tested for viral nucleic acid in throat swabs. At the same time, peripheral blood leukapheresis was collected from both groups of patients, and their IL-6, IL-8, IL-1β, and TNF-α levels were detected, along with the levels of T-cell differentiation markers CD4 and CD8, to assess the influence of influenza virus on the immune function of elderly COPD patients and its relevance to the acute exacerbation of airway inflammatory response in elderly COPD patients. Results Results showed that the expression of inflammatory cytokines IL-6, IL-8, IL-1β and TNF-α was significantly higher in the viral group compared with the non-infected group (P < 0.05, P < 0.01). The levels of T cell differentiation type markers CD4 and CD8 were significantly lower in the infected group compared with the uninfected group. Conclusion Influenza virus further exacerbated airway inflammatory response and decreased the immune function of T cells by activating intrinsic immune molecules such as IL-6, IL-8, IL-1β and TNF-α.