bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case Report and Literature Review of a Giant Parathyroid Adenoma with Digestive System Symptoms and Brown Tumor
Authors: Pan Wen-ting , Zhao Zhi-Hong , Wang Kun , Ou Liang 
Published: May 2024

Abstract

Background: A parathyroid adenoma stands as the primary cause of primary hyperparathyroidism, and clinically it often presents with symptoms such as elevated blood calcium levels and recurrent kidney stones. Parathyroid adenoma discovered due to symptoms such as nausea and vomiting is relatively rare.
Case presentation: A 59-year-old woman was hospitalized due to symptoms of nausea and vomiting. Imaging studies unveiled a solid mass located on the posterior aspect of the left thyroid lobe, potentially of parathyroid origin, along with multiple bone destruction throughout the body. Laboratory tests showed elevated serum total calcium, low potassium, and increased parathyroid hormone levels. The final diagnosis was primary hyperparathyroidism complicated by the brown tumor. Symptomatic treatment, including calcium reduction, fluid replacement, and electrolyte supplementation, was initiated. Subsequently, parathyroid adenoma resection was performed. Postoperatively, the patient developed hungry bone syndrome, which was treated with calcium supplementation, and follow-up showed normalization of blood calcium levels.
Conclusions: Unexplained nausea accompanied by electrolyte disturbances should raise suspicion of rare causes such as primary hyperparathyroidism. When there are multiple systemic osteolytic changes, brown tumor should be considered, along with assessment of serum calcium and parathyroid hormone levels for diagnosis.
A Child-Friendly Approach: Leveraging Illusory Motion Designs for Early Dyslexia Diagnosis
Authors: Rasouli Zahra , Rasouli Saifollah , Salehi Javad 
Published: May 2024

Abstract

Dyslexia, a prevalent learning disorder, poses significant challenges for affected children, impacting their educational, social, and psychological well-being. Visual perception and processing difficulties are common among children with dyslexia. Leveraging illusory motions, we investigated the neurobiology of vision indirectly and non-invasively. In this research, we present a pattern-driven approach by leveraging illusory motion designs for early dyslexia diagnosis in preschool children. Our descriptive study focused on dyslexic and normal students aged six to nine years in Zanjan city during the 2020-2021 academic year. The dyslexic group (n = 19) comprised students from four learning disorder centers, while the normal group (n = 35) included students from selected schools in districts 1 and 2. We employed 11 illusory motion designs as research tools. Data analysis revealed significantly lower illusory motion perception in dyslexic children compared to their normal peers. Notably, our study introduces an illusory motion stimulus with high potential for early dyslexia diagnosis. It successfully identified illusory movement in 94% of healthy children and 32% of dyslexic children. This innovative approach holds promise for predicting reading disorders during education and serves as a valuable screening tool for vulnerable children before entering school.
Use of short single-balloon enteroscopy in patients with surgically altered anatomy: A single-center experience
Authors: Ding Songming , Dong Shanjie , Zhu Hengkai , Hu Yiting , Zheng Shusen , Li Qiyong 
Published: May 2024

Abstract

Conventional duodenoscopy is challenging to perform in patients with a surgically altered anatomy (SAA). Short single-balloon enteroscopy (SBE) is an innovative alternative. We investigated the performance of short SBE in patients with SAA and explored risk factors for unsuccessful intubation. Patients who underwent short SBE from October 2019 to October 2023 were retrospectively analyzed. Successful enteroscopic intubation was defined as endoscope reaching the target site of the afferent limb and identification of the papilla of Vater or pancreaticobiliary-enteric anastomosis. In total, 99 short SBE procedures were performed in 64 patients (40 men, 24 women) with a mean age of 61 years (range, 36–86 years). The patients had a history of choledochoduodenostomy (n = 1), Billroth II gastrojejunostomy (n = 11), pancreaticoduodenectomy (n = 17), Roux-en-Y reconstruction with hepaticojejunostomy (n = 31), and Roux-en-Y reconstruction with total gastrectomy (n = 4). Successful enteroscopic intubation occurred in 57 of 99 (57.6%) procedures. No perforation or severe pancreatitis occurred. Multivariable analysis showed that Roux-en-Y reconstruction was a risk factor for intubation failure (hazard ratio, 4.2; 95% confidence interval, 1.1–15.8; p = 0.033). Short SBE is efficacious and safe in patients with postsurgical anatomy. Roux-en-Y reconstruction adversely affects the success of short SBE intubation.
Dual role of the ∆Np63-miR-141-3p-YAP1 axis in regulating proliferation, migration, and EMT in different cervical carcinoma cell lines
Authors: Panahi-Moghadam Somayeh , Sadeghizadeh Majid , Farivar Shirin , Vakhshiteh Faezeh 
Published: May 2024

Abstract

Cervical cancer (CC) represents a substantial public health burden, requiring the development of inventive therapeutic approaches. This study explored the functional relationship between the p63 isoform (ΔNp63) and miR-141-3p in modulating migration, invasion, and epithelial–mesenchymal transition (EMT) in two CC cell lines, CaSki, which are human cervical squamous carcinoma cells, and HeLa, which are human cervical adenocarcinoma cells. Our findings revealed dual functions of the ΔNp63-miR-141-3p-YAP1 axis, demonstrating its prometastatic role in HeLa cells through the upregulation of YAP1 and the promotion of proliferation, migration, invasion, and EMT. Conversely, the same axis demonstrated an antimetastatic function in CaSki cells by downregulating YAP1. Notably, YAP1 expression is significantly greater in ADC than in SCC, highlighting its contribution to the aggressive nature of ADC. These data indicate that targeting the ΔNp63-miR-141-3p-YAP1 axis can offer subtype-specific therapeutic options for managing CC.
Can we rely on the orocecal transit time measured by the lactulose breath test? Simultaneous measurement of Tc99m colloid scintigraphy and lactulose breath hydrogen test in asymptomatic volunteers
Authors: von Muhlenbrock Christian , Landskron Glauben , Massardo Teresa , Muñoz Pablo , Herrera Karin , Madrid Ana Maria 
Published: May 2024

Abstract

INTRODUCTION: The measurement of orofecal transit time (OCTT) has various challenges; its calculation through the detection of hydrogen in exhaled air with lactulose (H2 breath test), a non-invasive and widely used technique, is controversial and not validated in the local population.
AIM: To demonstrate the correlation between techniques for measuring OCTT through the simultaneous use of intestinal scintigraphy with radiolabeled colloid (OCTT-R) and lactulose breath hydrogen test (OCTT-H2).
METHOD: Healthy volunteers over 18 years old underwent a 12-hour fast, followed by oral administration of colloid sulfur mixed with lactulose. Simultaneously, abdominal images were obtained using a gamma camera, and breath samples were collected every 10 minutes for 180 minutes. The lactulose orocecal transit time (OCTT-H2) was considered when the curve elevation exceeded 20 ppm above the baseline value, after the first 60 minutes of the study. The orocecal transit time with radioisotopes (OCTT-R) corresponding to 50% activity of the tracer administered in the cecum was quantified.
RESULTS: Seventeen patients aged between 22 and 77 years (82% women) were included. OCTT-R varied between 73 and 180 minutes and OCTT-H2 between 60 and 130 minutes. OCTT-R with radioisotopes and OCTT-H2 showed a good correlation (r: 0.794; 95% CI: 0.508 - 0.923). Results of orocecal transit time with radioisotopes versus H2 did not have significant differences (p= 0.959).
CONCLUSION: OCTT-H2 is feasible to measure using lactulose as a substrate with a good correlation and no difference with isotopic technique.­­­
A Novel Polyp Retrieval Bag Reduces the Polyp Fragmentation Rate in Colon Polypectomy : A Single-Blind Randomized Controlled Study
Authors: Chu Jindong , Ma Cuiyun , Min Min , Bi Qian , Shen Wei , Zhang Xueting , Zhang Hanqing , Li Aitong , Liu Yan , Lu Zheng 
Published: May 2024

Abstract

Purpose
The fragmentation of polyps affects complete resection confirmation. The primary aim of this study was to assess the feasibility of a novel polyp retrieval bag for reducing the fragmentation rate of colon polyps.
Methods
Patients with a 5–15 mm colon polyp were recruited and randomized to two groups at a 1:1 ratio. After polyp resection, polyps obtained from patients in the treatment group were extracted using a novel polyp retrieval bag without traversing the instrument channel, while polyps obtained from patients in the control group were collected by traversing the instrument channel, attaching the polyp trap to the instrument channel port and applying suction.
Results
From January to July, 2022, a total of 225 patients were assessed for study eligibility. A total of 204 patients were enrolled in the study, and seven patients with specimen retrieval failure were excluded from the analysis. The polyp fragmentation rate in the treatment group was significantly lower than that in the control group (3.0% [3/100] vs. 17.5% [17/97], P = 0.001). There was no significant difference in the retrieval failure rates between the treatment group and control group (2.0% [2/102] vs. 4.9% [5/102], P = 0.442). There were fewer colonoscope insertions in the treatment group than in the control group (102 vs. 110), but a significant difference was not present (P = 0.065). No significant adverse events were observed in the follow-up.
Conclusions
This study demonstrated that the polyp retrieval bag was safe and feasible for reducing the fragmentation rate of retrieved polyps.
Trial registration:
The study was registered at ClinicalTrials.gov ( NCT05189912, 1/12/2021).
Applying Metabolomics and Aptamer-based Proteomics to Determine Pathophysiologic Differences in Decompensated Cirrhosis Patients Hospitalized with Acute Kidney Injury
Authors: Cullaro Giuseppe , Allegretti Andrew S. , Patidar Kavish R. , Verna Elizabeth C. , Lai Jennifer C. 
Published: May 2024

Abstract

Methods
A case-control study of 97 patients hospitalized at our institution. We performed aptamer-based proteomics and metabolomics on serum biospecimens obtained within 72 hours of admission. We compared the proteome and metabolome by the AKI phenotype (i.e., HRS-AKI, ATN) and by AKI recovery (decrease in sCr within 0.3 mg/dL of baseline) using ANCOVA analyses adjusting for demographics and clinical characteristics. We completed Random Forest (RF) analyses to identify metabolites and proteins associated with AKI phenotype and recovery. Lasso regression models were developed to highlight metabolites and proteins could improve diagnostic accuracy. Results: ANCOVA analyses showed no metabolomic or proteomic differences by AKI phenotype while identifying differences by AKI recovery status. Our RF and Lasso analyses showed that metabolomics can improve the diagnostic accuracy of both AKI diagnosis and recovery, and aptamer-based proteomics can enhance the diagnostic accuracy of AKI recovery. Discussion: Our analyses provide novel insight into pathophysiologic pathways, highlighting the metabolomic and proteomic similarities between patients with cirrhosis with HRS-AKI and ATN while also identifying differences between those with and without AKI recovery.
Microsurgical treatment for superior petrosal sinus dural arteriovenous fistulas
Authors: Sun Liyong , Su Xin , Ma Yongjie , Ye Ming , Hong Tao , Zhang Peng , Zhang Hongqi 
Published: May 2024

Abstract

Background and Objectives:
Superior petrosal sinus (SPS) dural arteriovenous fistulas (DAVFs), is a relatively common type of tentorial DAVF that sometimes need to be treated microsurgically. The purpose of this study is to analyze the superior petrosal vein (SPV) tributaries observed during surgery, as well as their relationship with clinical symptoms and venous drainage patterns.
Methods
This retrospective study examined a consecutive series of 34 patients with SPS DAVFs who underwent microsurgical treatment at a single institution from 2014 to 2022.
Expected Outcomes:
34 patients had an average age of 52.8 ± 11.8 years (range, 25–73), with 85.3% (29/34) being men. The most common symptoms were venous hypertensive myelopathy (VHM) (55.9%, 19/34) and intracranial hemorrhage or subarachnoid hemorrhage (23.5%, 8/34). 94.1% (32/34) of the lesions were ligated using the standard retrosigmoid approach. Immediate complete occlusion of the fistulas was achieved in all patients. A higher frequency of subarachnoid hemorrhage or intracerebral haemorrhage and venous varix was observed in supratentorial venous drainage pattern (P = 0.047). VHM-related symptoms are more common in infratentorial venous drainage patterns (P<0.001). 90% of SPS DAVFs drained supratentorially via the pontotrigeminal vein. 61.5% of SPS DAVFs drained infratentorially via the vein of the cerebellopontine fissure (VCPF). 90% of cases drained into the perimedullary venous system via the VCPF or TPV, and lateral anterior medullary veins, while the remaining cases drained infratentorially into cerebellar cortical veins.
Discusssion:
Endovascular treatment for SPS DAVFs can be risky, even though most tentorial DAVFs can be effectively treated via TAE. SPS DAVFs can be managed through a standard retrosigmoid craniotomy, leading to favorable clinical outcomes and high cure rates. In cases with supratentorial venous drainage, the most common arterialized tributary of the SPV is the VCPF, whereas in cases with infratentorial venous drainage, the most common arterialized SPV tributary is the PTV.
A retrospective investigation of the effects of chromosome aneuploidy on preimplantation embryos’ development: base on time-lapse
Authors: Chen Zhihui , Yao Yufei , Ma Yanlin , Zhong Qingfei , Zhang Yu , Huang Yuanhua 
Published: May 2024

Abstract

Purpose To investigate the effects of chromosomal aneuploidy on preimplantation embryos’ development by analyzing the morphological and morphokinetic parameters between euploid embryos and aneuploid embryos.Methods Conducted a retrospective analysis of the morphological and morphokinetic parameters of embryos cultured in the Embryo Scope Plus time-lapse incubator and underwent trophectoderm cell sampling for preimplantation genetic testing (PGT) at the Reproductive Center of the First Affiliated Hospital of Hainan Medical University from June 2019 to September 2022. Statistical methods, including the Mann-Whitney U test and Chi-Square test, were used to analyze the data.Results 1. A total of 1888 embryos from 487 cycles were included, with 724 being euploid embryos (38.30%) and 1164 being aneuploid embryos (61.70%). 2.In embryos that has become blastocysts, aneuploidy of embryonic genome had no effect on morphology of D1 and D2 embryos, had moderate effect on D3 embryos but significantly affects blastocysts, the worse the Gardner score, the higher the aneuploidy rate. 3. The influence of aneuploidy on the morphokinetic of the embryo becomes apparent at t5, with euploid embryos exhibiting faster development compared to aneuploid embryos. 4.There is no evidence to suggest that single chromosome aneuploidies, such as chr-3, chr-7, chr-8, chr-10, chr-11, chr-12, chr-13, chr-15, chr-18, chr-20, and chr-21, has any influence on the morphokinetic of embryos.Conclusion Genomic aneuploidy has an impact on embryo development, but not every stage is affected. Additionally, certain specific single chromosome aneuploidies does not influence embryo development during the preimplantation stage.
Efficient Implementation of AI Algorithms on an FPGA-based System for Enhancing Blood Vessel Segmentation
Authors: Alsharari Majed , Mai Son Thai , Garnier Romain , Reano Carlos , Woods Roger 
Published: May 2024

Abstract

Machine learning offers the potential to enhance real-time image analysis in surgical operations. This paper presents results from the implementation of machine learning algorithms targeted for an intelligent image processing system comprising a custom CMOS image sensor and field programmable gate array (FPGA). A novel method is presented for efficient image segmentation and minimises energy usage and requires low memory resources, which makes it suitable for implementation. Using two eigenvalues of the enhanced Hessian image, simplified traditional machine learning and deep learning methods are employed to learn the prediction of blood vessels. Quantitative comparisons are provided between different machine learning models based on accuracy, resource utilisation, throughput, and power usage. It is shown how a gradient boosting decision tree with 1000 times fewer parameters can achieve comparable state-of-the-art performance whilst only using a much smaller proportion of the resources and producing a 200 MHz design that operates at 1,779 frames per second at 3.85 W, making it highly suitable for the proposed system. A methodology for implementing the AI algorithms onto FPGA is presented and then used to provide additional results by extending the original work to a 512 × 512 image size along with more detailed analysis.
Unveiling ECRAM Switching Mechanism Using Variable Temperature Hall Measurements for Accelerated AI Computation
Authors: Kim Seyoung , Kwak Hyunjeong , Choi Junyoung , Kim Eun , Kim Chaeyoun , Solomon Paul , Lee Junyong , Kim Doyoon , Shin Byungha , Lee Donghwa , Gunawan Oki 
Published: May 2024

Abstract

Electrochemical random-access memory (ECRAM) devices are promising cross-point elements for implementing analog cross-point array-based AI computation accelerators due to their remarkable programmability and high-stability driven by ion movement. However, efforts to investigate the fundamental physical parameters governing switching have been limited by the complexity of ECRAM multilayer film structure and the low mobility and high-resistivity of the oxide material. Additionally, tracking the movement of oxygen vacancies within metal oxides has been challenging compared to other active ions. Herein, we fabricate ECRAM devices with multi-terminal Hall-bar structures and conduct AC magnetic parallel dipole line (PDL) Hall measurements. Using two rotating DC magnets and lock-in technique, we extract key transport parameters such as mobility and carrier density of high-resistivity WO3-x channel layer. Through variable-temperature Hall measurements at 50 - 300 K, we experimentally measure, for the first time, the oxygen donor level at approximately 0.1 eV in WO3-x thin film. In addition, we characterize the resistive switching of ECRAM at low temperatures, for the first time, and reveal that the conductance potentiation is caused by increase in both mobility and carrier density. This phenomenon can be attributed to the reversible changes in electronic and atomic structure supported by density functional theory calculation result. Overall, our experimental study on ECRAM switching mechanism contributes to a deep understanding of the operational principles of ECRAM and provides valuable insights for enabling high-performance and energy-efficient AI computation in analog hardware.
Greedy Minimum-Energy Scheduling
Authors: Bidlingmaier Gunther 
Published: May 2024

Abstract

We consider the problem of energy-efficient scheduling across multiple processors with a power-down mechanism. In this setting a set of $n$ jobs with individual release times, deadlines, and processing volumes must be scheduled across $m$ parallel processors while minimizing the consumed energy.When idle, each processor can be turned off to save energy, while turning it on requires a fixed amount of energy.For the special case of a single processor, the greedy Left-to-Right algorithm \cite{irani_left_to_right_soda_2003} guarantees an approximation factor of $2$.We generalize this simple greedy policy to the case of $m \geq 1$ processors running in parallel and show that the energy costs are still bounded by $2 \OPT + P$, where $\OPT$ is the energy consumed by an optimal solution and $P < \OPT$ is the total processing volume.Our algorithm has a running time of $\mathcal{O}(n f \log d)$, where $d$ is the difference between the last deadline and the earliest release time, and $f$ is the running time of a maximum flow calculation in a network of $\mathcal{O}(n)$ nodes.
Experimental study of the seismic performance of pile groups with integrated building-bridge structure in liquefiable soils: a case study
Authors: KONG Chao , ZHOU Chunjiang , GU Song , DAI Yong , DAI Zhenyang , DU Yixiang 
Published: May 2024

Abstract

The integrated building-bridge structure system exemplifies integrated railway stations in China and has emerged as a new structural approach in recent years. This paper presents a case study on large shaking table tests that explore various seismic responses of a pile group system based on the Kunming South Railway Station. The study focused on the dynamic characteristics of the soil and pile-superstructure. Findings indicate that the pile damage is primarily on the side facing the direction of vibration, with the middle pile experiencing greater damage than the corner pile. Hysteresis is observed in the growth of pore pressure ratio during the liquefaction of saturated soils. Both the bending moment and ground pressure on the pile increase with the degree of liquefaction. The greatest pile bending moment occurs at the interface between liquefied and non-liquefied soil layers. During seismic activity, side piles facing the vibration direction experience increased seismic surcharge loads, while the center piles experience smaller loads due to the isolation effect of the side piles.
The Role of Ethnic Enclaves and Neighborhood Socioeconomic Status in Invasive Breast Cancer Incidence Rates Among Asian American, Native Hawaiian, and Pacific Islander Females in California
Authors: Truong Alya , McKinley Meg , Gomez Scarlett Lin , Kim Mi-Ok , Shariff-Marco Salma , Cheng Iona 
Published: May 2024

Abstract

Purpose
Few studies have examined whether the incidence rates of invasive breast cancer among Asian American, Native Hawaiian, and Pacific Islander (AANHPI) populations differ by the neighborhood social environment. Thus, we examined associations of ethnic enclave and neighborhood socioeconomic status (nSES) with breast cancer incidence rates among AANHPI females in California.
Methods
A total of 14,738 AANHPI females diagnosed with invasive breast cancer in 2008–2012 were identified from the California Cancer Registry. AANHPI ethnic enclaves (culturally distinct neighborhoods) and nSES were assessed at the census tract level using 2007–2011 American Community Survey data. Breast cancer age-adjusted incidence rates and incidence rate ratios (IRRs) were estimated for AANHPI ethnic enclave, nSES, and their joint effects. Subgroup analyses were conducted by stage of disease.
Results
The incidence rate of breast cancer among AANHPI females living in lowest ethnic enclave neighborhoods (quintile (Q)1) were 1.21 times (95% Confidence Interval (CI) 1.11, 1.32) that of AANHPI females living highest ethnic enclave neighborhoods (Q5). In addition, AANHPI females living in highest vs. lowest SES neighborhoods had higher incidence rates of breast cancer (Q5 vs. Q1 IRR = 1.30, 95% CI 1.22 to 1.40). The incidence rate of breast cancer among AANHPI females living in low ethnic enclave + high SES neighborhoods was 1.32 times (95% CI 1.25, 1.39) that of AANHPI females living in high ethnic enclave + low SES neighborhoods. Similar patterns of associations were observed for localized and advanced stage disease.
Conclusion
For AANHPI females in California, incidence rates of breast cancer differed by nSES, ethnic enclave, when considered independently and jointly. Future studies should examine whether the impact of these neighborhood-level factors on breast cancer incidence rates differ across specific AANHPI ethnic groups and investigate the pathways through which they contribute to breast cancer incidence.