bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic-assisted distal colon excision and proximal colon pull-through anorectoplasty for anorectal malformation
Authors: Li Siqi , Ye Shiru , Zhou Yan , Diao Mei , Li Long 
Published: May 2024

PurposeDuring the second stage surgery for anorectal malformations (ARM), patients whose distal intestine of the colostomy is particularly short underwent laparoscopic-assisted distal colon excision and proximal colon pull-through anorectoplasty (PCPARP). This study aimed to discuss the outcomes of PCPARP after colostomy in patients with ARM.MethodsThis is a single-center propensity score-matched (PSM) study which was retrospectively initiated patients with intermediate- or high-type ARM who underwent laparoscopic surgery from June 2007 to December 2018. These patients were divided into PCPARP group and conventional laparoscopic-assisted anorectoplasty (LAARP) group according to specific surgical methods. The general data, surgical data, postoperative complications, and functional results were evaluated.ResultsIn total, 216 patients were included in this study: 190 (88.0%) undergoing LAARP approach and 26 (12.0%) undergoing PCPARP approach. After PSM, two well-balanced groups of 26 patients were analyzed and showed the postoperative complications (P = 0.126) and bowel function (P = 0.809) were similiar between the two groups.ConclusionsThe curative effect of PCPARP after colostomy is similar to that of classic LAARP surgery, which can be used for ARM patients with a very short and abnormal distal intestine of the stoma.
Teriparatide: an innovative and promising strategy for protecting the blood-spinal cord barrier following spinal cord injury
Authors: Xiong Moliang , Feng Yun , Luo Caiguang , Guo Jia , Zeng Jihuan , Deng Liang , Xiao Qiang 
Published: May 2024

Graphical AbstractThis figure was generated using Figdraw software.
Population pharmacokinetics, dosing optimization and clinical outcomes of biapenem in patients with sepsis
Authors: Chen Dayu , Wu Xuanyu , Zhang Haixia , Yao Huimin , Jin Lu , Luo Xuemei , Liu Jinchun , Wu Zejun , Li Yuanchen , Xu Wei , Ge Weihong , Chen Xingkai , Zhu Huaijun 
Published: May 2024

Introduction: Biapenem is a carbapenem antibiotic widely used in Asia, can be used for the treatment of adults and children with infections due to susceptible bacteria. Although biapenem is utilized in the treatment of a diverse range of bacterial infections, current pharmacokinetic data in the context of septic populations remain limited. Consequently, our research aims to evaluate the pharmacokinetics and efficacy of biapenem within a septic population to optimize biapenem therapy.Methods: In this study, we characterized the pharmacokinetics of biapenem in septic patients using a population pharmacokinetic (PPK) approach. The clinical PK data to develop the PPK model were obtained from 317 septic patients admitted to Nanjing Drum Tower Hospital between 2018 and 2022. All patients were randomized to the modeling and validation cohorts at a 3:1 ratio, with PPK modeling and validation performed utilizing the NONMEM software.Results: The model found to best describe the available data was a two-compartment PPK model with first-order elimination characterized by the parameters clearance (CL), central volume (V1), peripheral volume (V2), and intercompartmental clearance (Q). A covariate analysis identified that creatinine clearance (CLCR) was a significant covariate influencing biapenem CL, while blood urea nitrogen (BUN) was a significant covariate influencing biapenem Q. Accoding to the clinical outcome analyses, 70% of the time that the free antimicrobial drug concentration exceeds the MIC (fT&gt;MIC) is associated with favourable clinical outcomes. The PPK model was then used to perform Monte Carlo simulations to evaluate the probability of attaining 70% fT&gt;MIC.Conclusions: A final PPK model of biapenem was established for patients with sepsis. The current daily dosage regimen of 1.2 g may insufficient to achieve 70% fT&gt;MIC in septic patients. The dosage regimen of 600 mg every 6 h appears to be the optimal choice.
Diagnostic accuracy and clinical utility of the PHQ-2 and GAD-2: a comparison with long-format measures for depression and anxiety
Authors: Hlynsson Jón Ingi , Carlbring Per 
Published: May 2024

BackgroundAnxiety and depression are highly prevalent and often comorbid mental disorders that are encompassed within the broad category of emotional disorders. The frequent comorbidity of anxiety and depression can pose challenges for accurate diagnosis and treatment which, in turn, highlights the need for reliable measurements that are simultaneously responsive to change and prevent non-response bias. Brief measures of anxiety and depression can potentially increase response rates due to their brevity and ease of administration. This study evaluates the psychometric characteristics, discriminative accuracy, and sensitivity to change of the Generalized Anxiety Disorder 2-item scale (GAD-2) and the Patient Health Questionnaire 2-item scale (PHQ-2) within a clinical population.MethodThe sample comprised treatment-seeking participants (n = 3,411), screened (n = 2,477) to receive an internet-based psychotherapeutic intervention (cognitive-behavioral, psychodynamic, or waitlist).ResultsBrief measures can effectively detect individuals who may be eligible for a diagnosis of depression and anxiety, not only prior to but also during and following the completion of psychological treatment. The discriminative ability of the GAD-2 was significantly greater during active treatment and at post-assessment compared with pre-treatment screening, although no such differences were found for the PHQ-2. Finally, endorsing the most severe response option on the GAD-2 and PHQ-2 was associated with a high probability of presenting with clinically relevant anxiety and depressive symptoms.ConclusionBrief measures of anxiety and depression are viable instruments to screen for and monitor anxiety and depressive symptoms.Clinical trial registrationClinicalTrials.gov, identifier NCT05016843.
Older adults coping with critical life events - results of the revised demoralization scale in a representative sample of older adulthood
Authors: Ramm Markus , Jedamzik Johanna , Lenz Philipp , Jürgens Lara , Heuft Gereon , Conrad Rupert 
Published: May 2024

BackgroundHigh suicide rates in older adults are a relevant public health concern. Social isolation or widowhood as well as physical decline play a crucial role for suicidality in older adulthood. Previous evidence suggested that demoralization is an important risk factor for suicide. Whether demoralization is a relevant phenomenon in older adulthood which possibly could account for high suicide rates remains unclear.MethodsDemoralization Scale II (DS-II) scores assessed in a survey of the German general population were investigated with respect to older adults (aged ≥ 65 years). DS-II scores were compared between older (≥ 65 years) and younger (&lt; 65 years) adulthood and between young-old (65–74y), middle-old (75–84y), and old-old (85+y) individuals. We tested the impact of sociodemographic factors on DS-II scores within older adults.ResultsThe sample comprised N = 545 adults ≥ 65 years and N = 1922 adults &lt; 65 years. DS-II scores increased in older compared to younger adults (F(1,2465) = 6.1; p = 0.013; d = 0.09) and further from young-old to old-old (Mdiff = 2.7; 95% CI 0.45, 5.46; p = 0.034). One-fourth of individuals ≥ 65 years and almost half of old-old individuals reported DS-II scores above the cut-off &gt; 5. Living with a partner protected from demoralization in old-old individuals.DiscussionThis study provides first evidence for an increased rate of demoralization in very old adults, in particular women, which is partly related to partnership status. We suggest that demoralization is considered as a crucial entity in older adulthood which can be missed by standard psychological screenings.
The influence of water safety knowledge on adolescents’ drowning risk behaviors: a framework of risk-protect integrated and KAP theory
Authors: Luo Shi , Luo Shulai , Ren Zhongyu , Zhang Hui , Li Xinyu , Liu Lian 
Published: May 2024

IntroductionAlthough previous research has examined the risk factors for drowning behavior among adolescents, it is unclear whether this association is influenced by water safety knowledge. This study aimed to examine whether water safety knowledge is associated with adolescents’ drowning risk behaviors and whether drowning risk perceptions and attitudes could have a chain mediating role in the association between water safety knowledge and adolescents’ drowning risk behaviors.MethodsThis study included 7,485 adolescents from five Chinese provinces and cities. We used the Drowning Risk Behaviors Scales (DRBS) to evaluate the risk of drowning behaviors. The Water Safety Knowledge Scale (WSKS) was used to evaluate the competence level of water safety knowledge. The Drowning Risk Perceptions Scale (DRPS) was used to evaluate the risk level of perceptions, and the Drowning Risk Attitudes Scale (DRAS) was used to evaluate the risk level of attitudes.ResultsThe results of the mediating effect test showed that water safety knowledge (WSK) affected drowning risk behaviors (DRB) through three indirect paths. Drowning risk perceptions (DRP) and attitudes (DRA) have significantly mediated the association between WSK and DRB. In conclusion, DRP and DRA can act as mediators between WSK and DRB, not only individually, but also as chain mediators, where the direct effect is-0.301, the total indirect effect is-0.214, and the total mediated indirect effect is 41.5%.DiscussionWater safety knowledge negatively predicts adolescents’ drowning risk behaviors; water safety knowledge has an inhibitory effect on drowning risk perceptions. Water safety knowledge can directly influence adolescents’ drowning risk perceptions and indirectly affect drowning risk behaviors through the mediation of drowning risk perceptions and attitudes comprising three paths: (1) the drowning risk perceptions mediation path, (2) the drowning risk attitudes mediation path, and (3) the drowning risk perceptions and attitudes mediation paths.
Effectiveness of hierarchical medical system and economic growth: based on China’s urban vs. rural health perspectives
Authors: Zhao Yongze , Qiao Qingyu , Xu Xian , Bian Ying 
Published: May 2024

BackgroundThe hierarchical medical system is an important measure to promote equitable healthcare and sustain economic development. As the population’s consumption level rises, the demand for healthcare services also increases. Based on urban and rural perspectives in China, this study aims to investigate the effectiveness of the hierarchical medical system and its relationship with economic development in China.Materials and methodsThe study analyses panel data collected from Chinese government authorities, covering the period from 2009 to 2022. According to China’s regional development policy, China is divided into the following regions: Eastern, Middle, Western, and Northeastern. Urban and rural component factors were downscaled using principal component analysis (PCA). The factor score formula combined with Urban–rural disparity rate (ΔD) were utilized to construct models for evaluating the effectiveness of the hierarchical medical system from an urban–rural perspective. A Vector Autoregression model is then constructed to analyze the dynamic relationship between the effects of the hierarchical medical system and economic growth, and to predict potential future changes.ResultsThree principal factors were extracted. The contributions of the three principal factors were 38.132, 27.662, and 23.028%. In 2021, the hierarchical medical systems worked well in Henan (F = 47245.887), Shandong (F = 45999.640), and Guangdong (F = 42856.163). The Northeast (ΔDmax = 18.77%) and Eastern region (ΔDmax = 26.04%) had smaller disparities than the Middle (ΔDmax = 49.25%) and Western region (ΔDmax = 56.70%). Vector autoregression model reveals a long-term cointegration relationship between economic development and the healthcare burden for both urban and rural residents (βurban = 3.09, βrural = 3.66), as well as the number of individuals receiving health education (β = −0.3492). Both the Granger causality test and impulse response analysis validate the existence of a substantial time lag between the impact of the hierarchical medical system and economic growth.ConclusionResidents in urban areas are more affected by economic factors, while those in rural areas are more influenced by time considerations. The urban rural disparity in the hierarchical medical system is associated with the level of economic development of the region. When formulating policies for economically relevant hierarchical medical systems, it is important to consider the impact of longer lags.
Technical efficiency and its convergence among village clinics in rural China: evidence from Shanxi Province
Authors: Ye Yun , Evans Richard , Huang Xiaojun , Xu Wei , Lu Wei 
Published: May 2024

IntroductionVillage clinics (VCs) are the foundation of the three-tiered health service system in China, delivering basic and routine outpatient services to citizens in rural China. VC technical efficiency and its convergence play a critical role in policy decisions regarding the distribution of health service resources in rural China.MethodsThis study measured VC technical efficiency (using the slacks-based measure model), its convergence (using the convergence model), and the factors that influence the convergence in Shanxi Province, China. Data were obtained from the Shanxi Rural Health Institute 2014–2018 Health Statistics Report, which involved 3,543 VCs.ResultsThe results showed that VC technical efficiency was low and differed by region. There was no α convergence in VC technical efficiency, but evidence of β convergence was found in Shanxi. The main factors that influence convergence were the building area of each VC (BA), proportion of government subsidies (PGS), and ratio of total expenditure to total income of each VC (RTETI).ConclusionThe government should increase investments in VCs and improve VC technical efficiency. Meanwhile, the government should be aware of and take measures to curb the inequity in VC technical efficiency among different regions and take suitable measures to curb this disparity.
Crizanlizumab in adult patients with sickle cell disease: a retrospective German analysis
Authors: Poppenborg Friederike , Röth Alexander , Yamamoto Raina , Reinhardt Hans Christian , Alashkar Ferras 
Published: May 2024

IntroductionThe marketing authorization for crizanlizumab (Adakveo®), indicated for the prevention of recurrent vaso-occlusive crises (VOCs) in sickle cell patients (pts) aged ≥16, was revoked by the European Medicines Agency (EMA) as the STAND study did not demonstrate a significant difference between crizanlizumab and placebo in annualized rates of VOCs.MethodsThis is a retrospective, monocentric analysis of adult pts with sickle cell disease (SCD) (age (median) 29 years, range 19-42, annual VOC rate 3, range 1-5, homozygous SCD (HbS/S) 50.0% (4/8)) receiving crizanlizumab as monotherapy at the University Hospital of Essen between Dec 2020 to May 2023 (observation time (median) 17.5 months, range 4.8-27.3). The results were compared to hydroxycarbamide (HC)-treated pts at maximum tolerated dose (MTD).ResultsAt 6, 9, and 12 months, mean VOC rate was 1.5 (range 0-3; N=6), 1.8 (range 0-3; N=5) and 4.0 (range 3-5; N=3), indicating a time-dependent increase in VOCs in crizanlizumab-treated pts (6-9 months: p=0.039; 6-12 months: p=0.008) (mean VOC rate in HC-treated pts: 6 months: 0.38, range 0-1 (N=8); 9 months: 0.50, range 0-2 (N=8); 12 months: 0.63, range 0-3 (N=8)). Serious adverse events were mandatory in 7 pts, resulting in 12 inpatient-admissions (acute chest syndrome (N=2), VOC-related pain crisis (N=9), infusion-related VOC (N=1)).ConclusionThese findings, together with the high economic burden of crizanlizumab in contrast to HC, do further support the revocation of crizanlizumab in Europe in our opinion. Physicians should consider the potential risks when making a therapeutic decision regarding the use of crizanlizumab outside of Europe.
Hubungan Orang Tua Sebagai Pendidik Dengan Pemberian Pendidikan Seks Pada Anak Usia Dini (4-6 Tahun) Di TK
Authors: Okvitasari Yenny 
Published: May 2024

Kurangnya pendidikan orang tua dalam pendidikan seks terhadap anak dan apabila tidak dimulai sejak dini akan menyebabkan anak mengetahui seks dari sumber yang salah. Wilayah Banjarmasin tercatatat perkara tahun 2017 kekerasan seksual terhadap anak dibawah umur dengan korban 30 kasus dan pelaku anak 11 kasus.Penelitian ini bertujuan untuk mengetahui Hubungan orang tua sebagai pendidik dengan pemberian pendidikan seks pada anak usia dini (4-6 tahun) di TK di Banjarmasin. Metode penelitian menggunakan analitik dengan pendekatan cross Sectional. Populasi penelitian ini seluruh orang tua anak berusia 4-6 tahun di TK Diberjumlah 20 murid. Teknik pengambilan sampel Accidental sampling dengan uji statistik menggunakan uji Spearman Rank. Hasil penelitian dari 20 responden, didapatkan dari 13 orang tua sebagai pendidik baik (65%) dengan pemberian pendidikan seks yang baik sebanyak 12 orang baik (60%). Ada Hubungan orang tua sebagai pendidik dengan pemberian pendidikan seks pada anak usia dini (4-6 tahun) di TK (ρ value 0,000 < α 0,05).
The Influence of Food Quality and Store Atmosphere on Consumer Satisfaction with Purchasing Decisions as an Intervening Variable
Authors: Huda Ferdian Hendrastama , Welsa Henny , Ningrum Nonik Kusuma 
Published: May 2024

This research aims to examine the influence of food quality and shop atmosphere on consumer satisfaction with purchasing decisions as an intervening variable (case study of Rocket Chicken in Kemusuk Sedayu Bantul). This research uses quantitative research methods. The variables in this research are food quality, store atmosphere, consumer satisfaction, and purchasing decisions. The respondents in this research were consumers at Rocket Chicken in Kemusuk Sedayu Bantul. The number of samples in this study was 200 people. The data source used is primary data. The data collection technique used was a questionnaire distributed via Google Form. Data analysis techniques use SPSS 23 which consists of validity and reliability tests, descriptive statistics, classical assumption tests, regression tests, hypothesis tests, coefficient of determination, and Sobel tests. The results of this research show that there is a positive and significant influence of food quality and shop atmosphere on consumer satisfaction with purchasing decisions as an intervening variable (Case Study of Rocket Chicken in Kemusuk Sedayu Bantul). Suggestions for future researchers to add other variables as intervening variables.
Pengungkapan Green Intellectual Capital: Studi Deskriptif
Authors: Dyna Rachmawati  , Paskalis Yosephien 
Published: May 2024

This study aims to describe the disclosure of green intellectual capital (GIC). GIC has not been widely explored in previous studies, especially in Indonesia. Therefore, this research will conduct a descriptive study of all public companies listed on the Indonesia Stock Exchange (IDX) with an observation period of 2020. The data collection method is documentation based on management letters in annual reports. The management letter used in this study consists of two reports, namely the report of the board of commissioners and the report of the board of directors. Management letters can be regarded as a new source of data used by companies to disclose GIC information. GIC disclosure is measured using the content analysis method on keywords that represent each GIC component. The results of the descriptive study show that, first, the financial (agriculture) is the sector that most (little) expresses GIC. Second, structural capital (environmental capital) is the most (little) GIC component disclosed in management letter. The results of this study contribute, first, practically; management in companies with GIC disclosure levels has special attention to the importance of sustainability through green innovation. Second, structural capital is the easiest component to disclose in a management letter because management’s main concern is capital expenditure. Third, academically; the results of this study can enrich the GIC literature in Indonesia
Keywords: environmental capital, green intellectual capital, human capital, relational capital, structural capital
Classification of Astronomical Spectra Based on Multiscale Partial Convolution
Authors: Wu Jingjing , He Yuchen , Wang Wenyu , Qu Meixia , Jiang Bin , Zhang Yanxia 
Published: May 2024

Abstract
The automated and efficient classification of astronomical spectra is an important research issue in the era of large sky surveys. Most current studies on automatic spectral classification primarily focus on specific data sets and demonstrate outstanding performance. However, the diversity in spectra poses formidable challenges for these classification models, as they exhibit limited capability to generalize across more comprehensive data sets. In response to these challenges, we pioneer a method called the multiscale partial convolution net (MSPC-Net), which amalgamates partial, large kernel, and grouped convolution to facilitate multilabel spectral classification. By harnessing the capabilities of partial convolution, MSPC-Net can effectively reduce the number of model parameters, accelerate the training process, and mitigate the overfitting issue. Integrating large kernel and grouped convolution empowers the model to capture local and global features simultaneously, enhancing its overall classification efficacy. To rigorously evaluate the model’s performance, we generate ten different data sets sourced from the Sloan Digital Sky Survey and Large Sky Area Multi-Object Spectroscopic Telescope. These data sets encompass stellar class, stellar subclass, and full classification, providing a comprehensive assessment across various application scenarios. The experimental results reveal that MSPC-Net consistently outperforms the other models across different data sets, especially demonstrating superior performance in the last two data sets with full classification. Consequently, MSPC-Net is poised to find extensive applications in the detailed classification for large-scale sky survey projects. This work not only addresses the challenges of generalization in spectral classification but also contributes significantly to the advancement of robust models for astronomical research.