bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving wound infection management: education and evaluation of an infection management pathway
Authors: Woo Kevin , Coca Pere , Moura Anabela , Woodmansey Emma , Styche Tim , Polignano Roberto 
Published: April 2024

Objective: To assess the clinical impact and acceptance of an infection management (IM) pathway, designed to improve the consistency of care of wound infection when introduced, and supported by an educational programme. Method: An education and evaluation programme (T3 programme) was-conducted in Portugal, Spain and Italy. This consisted of a two-hour educational, virtual seminar, followed by a four-week evaluation of an IM pathway during which survey data were collected on the impact of this pathway on clinician-selected patients. Finally, all participants reconvened for a virtual meeting during which the combined results were disseminated. The pathway provided guidance to clinicians regarding the targeted use of antimicrobial wound dressings according to the presence and absence of signs and symptoms of wound infection. Results: Responses relating to 259 patients treated according to the IM pathway, 139 (53.7%) of whom had received previous antimicrobial treatment, were captured. Signs and symptoms of infection resolved within four weeks of treatment in >90% of patients. All 25 patients who had received prior antimicrobial treatment for ≥3 months experienced a resolution in the signs and symptoms of infection within four weeks. The majority of participating clinicians agreed that the IM pathway improved decision-making (94.9%) and confidence (97.3%), and helped to determine the correct antimicrobial treatment (91.4%) in the context of wound infection. Conclusion: The T3 programme was an efficient way to deliver a structured educational programme. The use of the IM pathway resulted in >90% of patients achieving resolution of their signs and symptoms of wound infection.
Safety and effectiveness of an antiseptic wound cleansing and irrigation solution containing polyhexamethylene biguanide
Authors: Rippon Mark G , Daly Kristian , Rogers Alan A , Westgate Samantha 
Published: April 2024

Objective: There is currently a wide range of cleansing and irrigation solutions available for wounds, many of which contain antimicrobial agents. The aim of this study was to assess the safety of HydroClean Solution (HARTMANN, Germany), a polyhexamethylene biguanide (PHMB)-containing irrigation solution, in a standard cytotoxicity assay, and to assess its effect in a three-dimensional (3D) full-thickness model of human skin. Method: A number of commercially available wound cleansing and irrigation solutions, including the PHMB-containing irrigation solution, were tested in a cytotoxicity assay using L929 mouse fibroblasts (ISO 10993-5:2009). The PHMB-containing irrigation solution was then assessed in an in vitro human keratinocyte–fibroblast 3D full-thickness wounded skin model to determine its effect on wound healing over six days. The effect of the PHMB-containing irrigation solution on tissue viability was measured using a lactate dehydrogenase (LDH) assay, and proinflammatory effects were measured using an interleukin-6 (IL-6) production assay. Results: The PHMB-containing irrigation solution was shown to be equivalent to other commercially available cleansing and irrigation solutions when tested in the L929 fibroblast cytotoxicity assay. When assessed in the in vitro 3D human full-thickness wound healing model, the PHMB-containing irrigation solution treatment resulted in no difference in levels of LDH or IL-6 when compared with levels produced in control Dulbecco's phosphate-buffered saline cultures. There was, however, a pronounced tissue thickening of the skin model in the periwound region. Conclusion: The experimental data presented in this study support the conclusion that the PHMB-containing irrigation solution has a safety profile similar to other commercially available cleansing and irrigation solutions. Evidence also suggests that the PHMB-containing irrigation solution does not affect tissue viability or proinflammatory cytokine production, as evidenced by LDH levels or the production of IL-6 in a 3D human full-thickness wound healing model. The PHMB-containing irrigation solution stimulated new tissue growth in the periwound region of the skin model.
Clinicopathological characteristics and typing of multilocular cystic renal neoplasm of low malignant potential
Authors: Gao Wen-Long , Li Gang , Zhu Dong-Sheng , Niu Yuan-Jie 
Published: April 2024

BACKGROUND
Up until now, no research has been reported on the association between the clinical growth rate of multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) and computed tomography (CT) imaging characteristics. Our study sought to examine the correlation between them, with the objective of distinguishing unique features of MCRNLMP from renal cysts and exploring effective management strategies.
AIM
To investigate optimal management strategies of MCRNLMP.
METHODS
We retrospectively collected and analyzed data from 1520 patients, comprising 1444 with renal cysts and 76 with MCRNLMP, who underwent renal cyst decompression, radical nephrectomy, or nephron-sparing surgery for renal cystic disease between January 2013 and December 2021 at our institution. Detection of MCRNLMP utilized the Bosniak classification for imaging and the 2016 World Health Organization criteria for clinical pathology.
RESULTS
Our meticulous exploration has revealed compelling findings on the occurrence of MCRNLMP. Precisely, it comprises 1.48% of all cases involving simple renal cysts, 5.26% of those with complex renal cysts, and a noteworthy 12.11% of renal tumors coexisting with renal cysts, indicating a statistically significant difference (P = 0.001). Moreover, MCRNLMP constituted a significant 22.37% of the patient population whose cysts demonstrated a rapid growth rate of ≥ 2.0 cm/year, whereas it only represented 0.66% among those with a growth rate below 2.0 cm/year. Of the 76 MCRNLMP cases studied, none of the nine patients who underwent subsequent nephron-sparing surgery or radical nephrectomy following renal cyst decompression experienced recurrence or metastasis. In the remaining 67 patients, who were actively monitored over a 3-year postoperative period, only one showed suspicious recurrence on CT scans.
CONCLUSION
MCRNLMP can be tentatively identified and categorized into three types based on CT scanning and growth rate indicators. In treating MCRNLMP, partial nephrectomy is preferred, while radical nephrectomy should be minimized. After surgery, active monitoring is advisable to prevent unnecessary nephrectomy.
Type one autoimmune pancreatitis based on clinical diagnosis: A case report
Authors: Zhang Bi-Yu , Liang Mou-Wang , Zhang Shuang-Xi 
Published: April 2024

BACKGROUND
Autoimmune pancreatitis (AIP) is a rare form of autoimmune-mediated pancreatitis, which is easily misdiagnosed as pancreatic cancer and thus treated surgically. We studied the diagnosis and treatment of a patient with type 1 AIP recently admitted to our hospital, and reviewed the literature to provide a reference for clinical diagnosis of AIP.
CASE SUMMARY
The chief complaint was yellowing of the body, eyes and urine for 21 d. The patient's clinical presentation was obstructive jaundice and imaging suggested pancreatic swelling. It was difficult to distinguish between inflammation and tumor. Serum immunoglobulin G4 (IgG4) was markedly elevated. IgG4 is an important serological marker for type 1 AIP. The patient was diagnosed with AIP, IgG4-related cholangitis, acute cholecystitis and hepatic impairment. After applying hormonal therapy, the patient's symptoms improved significantly. At the same time, imaging suggested that pancreatic swelling subsided, and liver function and other biochemical indicators decreased. The treatment was effective.
CONCLUSION
In patients with pancreatic swelling, the possibility of AIP should be considered.
Ultrasound-guided sphenopalatine ganglion block for effective analgesia during awake fiberoptic nasotracheal intubation: A case report
Authors: Kang Hangil , Park Seongjae , Jin Yehun 
Published: April 2024

BACKGROUND
Awake fiberoptic nasotracheal intubation (AFNI) is the preferred airway management strategy for patients with difficult airways. However, this procedure can cause significant physical and psychological distress. This case report explores the application of a sphenopalatine ganglion (SPG) block as an alternative analgesic modality to mitigate the discomfort associated with AFNI.
CASE SUMMARY
A 63-year-old female with a history of right maxillary osteosarcoma underwent craniotomy for a suspected malignant brain lesion. The patient’s medical history included prior surgery, chemotherapy, and radiation therapy, resulting in significant jaw impairment and limited neck mobility. Considering the anticipated airway challenges, AFNI was planned. A SPG block was performed under real-time ultrasound guidance, providing effective analgesia during nasotracheal intubation.
CONCLUSION
The SPG block represents a promising analgesic approach in AFNI, offering potential benefits in alleviating pain involving the nasal and nasopharyngeal regions as well as improving patient cooperation.
Appendiceal bleeding caused by vascular malformation: A case report
Authors: Ma Qin , Du Jin-Jie 
Published: April 2024

BACKGROUND
Acute lower gastrointestinal bleeding (LGIB) is a common occurrence in clinical practice. However, appendiceal bleeding is an extremely rare condition that can easily be overlooked and misdiagnosed. The preoperative detection of appendiceal bleeding often poses challenges due to the lack of related guidelines and consensus, resulting in controversial treatment approaches.
CASE SUMMARY
We presented a case of a 33-year-old female who complained of hematochezia that had lasted for 1 d. Colonoscopy revealed continuous bleeding in the appendiceal orifice. A laparoscopic appendectomy was performed immediately, and a pulsating blood vessel was observed in the mesangium of the appendix, accordingly, active bleeding into the appendicular lumen was considered. Pathological examination revealed numerous hyperplastic vessels in the appendiceal mucosa and dilated capillary vessels.
CONCLUSION
The preoperative detection of appendiceal bleeding is often challenging, colonoscopy is extremely important, bowel preparation is not routinely recommended for patients with acute LGIB or only low-dose bowel preparation is recommended. Laparoscopic appendectomy is the most appropriate treatment for appendiceal bleeding.
Can life events predict first-time suicide attempts? A nationwide longitudinal study
Authors: Christoffersen Mogens Nygaard , Khan Lorraine 
Published: April 2024

The prevention paradox describes circumstances in which the majority of cases with a suicide attempt come from a population of low or moderate risk, and only a few from a ‘high-risk’ group. The assumption is that a low base rate in combination with multiple causes makes it impossible to identify a high-risk group with all suicide attempts.
The best way to study events such as first-time suicide attempts and their causes is to collect event history data. Administrative registers were used to identify a group at higher risk of suicidal behaviour within a population of six national birth cohorts (N = 300,000) born between 1980 and 1985 and followed from age 15 to 29 years. Estimation of risk parameters is based on the discrete-time logistic odds-ratio model.
Lifetime prevalence was 4.5% for first-time suicide attempts. Family background and family child-rearing factors were predicative of later first-time suicide attempts. A young person’s diagnosis with psychiatric or neurodevelopmental disorders (ADHD, anxiety, depression, PTSD), and being a victim of violence or sex offences contributed to the explanatory model. Contrary to the prevention paradox, results suggest that it is possible to identify a discrete high-risk group (<12%) among the population from whom two thirds of all first-time suicide attempts occur, but one third of observed suicide attempts derived from low- to moderate-risk groups.
Findings confirm the need for a combined strategy of universal, targeted and indicated prevention approaches in policy development and in strategic and practice responses, and some promising prevention strategies are presented.
CT findings and clinical effects of high grade pancreatic intraepithelial neoplasia in patients with intraductal papillary mucinous neoplasms
Authors: Kim Min Cheol , Kim Jung Hoon , Jeon Sun Kyung , Kang Hyo-Jin 
Published: April 2024

Purpose
To investigate the common CT findings of high-grade (HG) PanIN and clinical effects in the remnant pancreas in patients with intraductal papillary mucinous neoplasm (IPMN) of the pancreas.

Materials and methods
Two hundred fifty-one patients with surgically confirmed IPMNs (118 malignant [invasive carcinoma/high-grade dysplasia] and 133 benign [low-grade dysplasia]) were retrospectively enrolled. The grade of PanIN (233 absent/low-grade and 18 high-grade) was recorded, and all patients underwent serial CT follow-up before and after surgery. Two radiologists analyzed CT findings of high-risk stigmata or worrisome features according to 2017 international consensus guidelines. They also analyzed tumor recurrence on serial follow-up CT after surgery. Statistical analyses were performed to identify significant predictors and clinical impact on postoperative outcomes of HG PanIN.

Results
PanIN grade showed a significant association with IPMN grade (p = 0.012). Enhancing mural nodules ≥5 mm, abrupt main pancreatic duct (MPD) changes with distal pancreatic atrophy, increased mural nodule size and MPD diameter were common findings in HG PanIN (P<0.05). In multivariate analysis, abrupt MPD change with distal pancreatic atrophy (odds ratio (OR) 6.59, 95% CI: 2.32–18.72, <0.001) and mural nodule size (OR, 1.05; 95% CI, 1.02–1.08, 0.004) were important predictors for HG PanIN. During postoperative follow-up, HG PanIN (OR, 4.98; 95% CI, 1.22–20.33, 0.025) was significantly associated with cancer recurrence in the remnant pancreas.

Conclusion
CT can be useful for predicting HG PanIN using common features, such as abrupt MPD changes and mural nodules. In HG PanIN, extra caution is needed to monitor postoperative recurrence during follow-up.
The Genes of Culture: Towards a Theory of Symbols, Meaning, and Media, Caroline Wiebe and Susan Maushart (eds), Christine L. Nystrom (2021–22)
Authors: Rose Phil 
Published: April 2024

Review of: The Genes of Culture: Towards a Theory of Symbols, Meaning, and Media, Vols 1&2, Caroline Wiebe and Susan Maushart (eds), Christine L. Nystrom (2021–22)
New York: Peter Lang Publishing Inc., 402 pp.,
ISBN 978-1-4331-7660-9, h/bk
ISBN 978-1-4331-8261-7, h/bk
Ærotomania: The Book of Lumenations, Adeena Karasick (2023)
Authors: Hicks Steven 
Published: April 2024

Review of: Ærotomania: The Book of Lumenations, Adeena Karasick (2023)
New Orleans, LA: Lavender Ink, 106 pp.,
ISBN 978-1-95692-112-0, p/bk, $25.95

Ouvert, Oeuvre: Openings & Touching in the Wake of the Virus, Adeena Karasick (2023)
New Orleans, LA: Lavender Ink, 96 pp.,
ISBN 978-1-95692-113-7, h/bk, $28.95
imbróglios da prestação regionalizada de serviços públicos de saneamento básico dos pequenos e médios municípios das Bacias dos Rios Piracicaba, Capivari e Jundiaí (PCJ), São Paulo
Authors: Inácio da Silva Elisa , De Carvalho Teixeira Branco Filho Thelmo , Malheiros Tadeu Fabrício 
Published: April 2024

O presente artigo advém de um relatório final de pesquisa de Iniciação Científica, oriundo da parceria entre a Universidade de São Paulo, a Universidade Federal do Rio Grande, o Convênio de Pesquisa Aplicada - firmado entre a FUSP/EESC/USP - e o Consórcio Intermunicipal das Bacias dos Rios Piracicaba, Capivari e Jundiaí (PCJ). Sendo o relato conclusivo do projeto de pesquisa, sua pertinência decorre da evidente notoriedade da temática do Saneamento Básico no Brasil com as recentes legislações que tem buscado pela universalização desse conjunto de serviços tão renegados ao longo da história do país. Com isso, o texto propôs-se ao estudo, por meio de uma análise comparativa, da situação dos pequenos e médios municípios inseridos na Bacia dos Rios Piracicaba, Jundiaí e Capivari, frente à Lei de Regionalização dos Serviços de Abastecimento de Água e Esgotamento Sanitário. Com esse intuito, foi realizada pesquisa do tipo análise comparativa, organizando e interpretando dados dos pequenos e dos médios municípios que compõem, por intermédio da coleta de dados e da revisão de literatura. Como resultado, observou-se que os municípios estudados se encontram em situação de precariedade, principalmente, em relação a efetividade de ações públicas que visem, de fato, à universalização do saneamento básico aos seus cidadãos.
Exploring The Gradual Islamization of Tana Toraja In South Sulawesi
Authors: Michael Anthonius , Masruri Siswanto , Husein Fatimah 
Published: April 2024

The profound journey of Islam's expansion in South Sulawesi during the 15th century resulted in a gradual uptake of Islam within the Toraja region. This delayed acceptance, compared to other areas in South Sulawesi, is frequently attributed to the use of force during Islam's expansion. This perception highlights the challenge of promoting tolerance between the Muslim minority and Christian majority in the region. To understand the complexities of this phenomenon, this study seeks to explore factors beyond violence that contributed to the slow pace of Islamization. Employing a qualitative approach based in anthropology, the research delves into historical and cultural contexts. It finds that forceful Islamization efforts by figures like the Bone Kingdom, Kahar Muzakkar, and Andi Sose, actually hampered the spread of Islam due to the negative cultural impacts they created. Instead, it was the migration of Muslims to Toraja for trade that played a key role in introducing Islam to the region. Intermarriages further altered the dynamics, shifting Islamization from a conversion-focused approach to one based on family connections. This had consequences for how Islamic communities developed, depending on the choices of second-generation Muslims. The slow pace of Islamization also influenced various aspects of social and religious life, leading the Toraja people to develop nuanced responses. They managed change by emphasizing positive aspects of Islam while minimizing negative ones, aiming to maintain peace within their religiously diverse society. Thus, the Toraja actively engaged in managing the evolving religious landscape, adapting their practices to maintain communal harmony.
The Characteristics of Urease Enzyme of Green Bean Seeds (Vigna radiata L.) and Its Activity as An Antifungal Against Candida albicans
Authors: Muslihah Niken Istikhari , Zusfahair Zusfahair , Ningsih Dian Riana , Nuradha Fajar 
Published: April 2024

Urease is an enzyme responsible for catalyzing the hydrolysis reaction of urea into CO2 and NH3. The urease isolated in this study came from green bean seeds. The urease enzyme was then tested for its antifungal activity against Candida albicans. The research aims to extract and characterize the urease enzyme from green bean seeds and explore its potential use as an antifungal agent. Green bean seeds were smoothed with a mortar and pestle, followed by homogenization using a stirrer and cold centrifugation. The crude extract of the urease enzyme was assessed for its activity through the Nessler method and measured by employing a UV-Vis spectrophotometer at a wavelength of 500 nm. The well-diffusion method was conducted to determine the antifungal activity of rough enzyme extracts against C. albicans. Positive controls were 100% ketoconazole, and negative controls used a pH buffer of 7. The characterization of the urease enzyme from green bean seeds revealed the optimum urease activity at a concentration of 0.25 M, pH level of 7, and an incubation temperature of 35°C with a value of 32.115 U/mL. Maximum reaction rate (Vmax) and Michaelis-Menten constant value (KM) were obtained at 56.497 U/mL and 0.215 M, respectively. Antifungal tests of C. albicans resulted in strong inhibitory activity at a concentration of 100% crude urease extract of 12 mm inhibition zone. The inhibitory concentration value grows at least 0.5% by 0.25 mm and positive control of 19.802 mm.
A Novel Fully Decoupled Scheme for the MHD System with Variable Density
Authors: Wang Zhaowei , Wang Danxia , Jia Hongen 
Published: April 2024

Abstract
In this paper, we first establish a novel first-order, fully decoupled, unconditionally stable time discretization scheme for the MHD system with variable density.
This scheme successfully decouples all the coupling terms by combining the gauge-Uzawa method and the scalar auxiliary variable (SAV) method.
And we prove its unconditional energy stability.
Then we give the first-order finite element scheme and its implementation.
Furthermore, we perform a rigorous error analysis of the proposed numerical scheme.
Finally, we perform some numerical experiments to demonstrate the effectiveness of the decoupling scheme.
Influence of Q&P-Parameters and Al-Content on the Microstructural Evolution of Lean-Medium-Mn-Steels
Authors: Höger K. , Kaar-Schickinger S. , Wallner M. , Schneider R. 
Published: April 2024

Abstract
This report investigates the impact of different heat treatment parameters and varying Al-contents on the microstructure of Quenching & Partitioning (Q&P) steels. Therefore, three lean-medium-Mn-steels with Al-contents between 0.3 and 0.9 wt-% underwent heat treatments according to Quenching & Partitioning regimes. For comparison, the steels were subjected to a transformation induced plasticity (TRIP) aided-bainitic-ferrite (TBF) process. In both cases, the samples were fully austenitized at 900 °C for 120 s, using dilatometry. For the Quenching & Partitioning process, the quenching temperature (TQ) ranged from 210 °C to 330 °C, while the transformation induced plasticity (TRIP) aided-bainitic-ferrite samples were cooled to 360 °C. Afterwards, the specimen were re-heated to the partitioning temperature (TP) of 400 °C and isothermally held for partitioning times (tp) of 40, 120 and 200 s. Subsequently, these steels were analyzed with regard to their phase fractions and hardness. The results indicated that in the Quenching & Partitioning process, the microstructure was primarily influenced by the partitioning temperature (TQ), while partitioning times (tp) played a minor role due to the time-independent martensitic transformation during quenching. In general, rising quenching temperature (TQ) led to an increase in retained austenite (RA) fraction. In the transformation induced plasticity (TRIP) aided-bainitic-ferrite (TBF) process, a substantial influence of partitioning times (tp) was found, which can be explained by the kinetics of the isothermal bainitic transformation. Regardless of the heat treatment concept, an increasing Al-content contributed to elevated retained austenite contents.