bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational approaches to therapeutic peptide discovery
Authors: Kliger Yossef 
Published: July 2010

AbstractThe development of peptides with therapeutic activities can be based on naturally occurring peptides or alternatively on de novo design. The discovery of natural peptides is often a matter of serendipity. In part, this is because natural peptides are typically proteolytically cleaved out from precursor proteins, a feature that averts the direct benefits of the genomic revolution. The first part of this review describes attempts to create a more systematic identification of natural peptides relying on a two step process. In the initial step, an in silico peptidome is predicted through the use of machine learning. Then, various computational biology tools are tailored to focus on peptides predicted to have the desired biological activity; for example, activating a GPCR or modulating the cellular arm of the immune system. The second part of the review is devoted to de novo peptide design and focuses on arguably the simplest scenario in which the designed peptide corresponds to a contiguous protein subsequence. Amongst these peptides, those corresponding to helical segments are prominent, mainly due to their relative ability to fold independently. Inspired by the clinical success of viral entry inhibitors, which are peptides corresponding to helical segments in viral envelope proteins, a computational tool for the identification of intramolecular helix–helix interactions was developed. Using this approach, peptides having anti‐cancer, anti‐angiogenic, and anti‐inflammatory activities have been recently rationally designed and biologically characterized. © 2010 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 94: 701–710, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
ChemInform Abstract: Synthesis and Structural Characterization of Gadolinium—Calcium Ferrites Gd1‐xCaxFeO3‐y (0 ≤ x ≤ 2/3).
Authors: LI J. , SONG D. , WANG T. M. , SU Z. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thermodynamics of Aqueous Mixtures of Magnesium Chloride with Sodium Chloride from 298.15 to 573.15 K. New Measurements of the Enthalpies of Mixing and of Dilution.
Authors: WANG P. , OAKES C. S. , PITZER K. S. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mg Composites for Hydrogen Storage. The Dependence of Hydriding Properties on Composition.
Authors: GROSS K. J. , SPATZ P. , ZUETTEL A. , SCHLAPBACH L. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: In situ STM Investigation of Metal Hydride Electrodes in Alkaline Electrolyte During Electrochemical Cycles.
Authors: CHARTOUNI D. , ZUETTEL A. , NUETZENADEL C. , SCHLAPBACH L. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Mass Spectral Studies of Some 1,2,4‐Oxa(thia)diazol‐5(4H)‐ones(thiones).
Authors: DUERUEST Y. , FAGGI C. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dendritic Styryl TADDOLs as Novel Polymer Cross‐Linkers: First Application in an Enantioselective Et2Zn Addition Mediated by a Polymer‐Incorporated Titanate
Authors: RHEINER P. B. , SELLNER H. , SEEBACH D. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spiro‐λ4‐sulfanes with a N—SIV—O Axial Bond System. A Kinetic Study on the Mechanism of Hydrolysis
Authors: VASS E. , RUFF F. , KAPOVITS I. , SZABO D. , KUCSMAN A. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: X=Y‐ZH Systems as Potential 1,3‐Dipoles. Part 48. Enantiopure Cycloadducts from Oxime—Nitrone—Isoxazolidine Cascades.
Authors: DONDAS H. A. , FREDERICKSON M. , GRIGG R. , MARKANDU J. , THORNTON‐PETT M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Diverse Cycloaddition Chemistry Leading to Overall Michael Addition in the Reactions of 1,1‐Bis(dimethylamino)‐2,2‐difluoroethene with α,β‐Unsaturated Aldehydes, Ketones, Esters, and Nitriles.
Authors: XU Y. , DOLBIER W. R. JUN. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical and Biochemical Properties of 2‐Hydroxypentadienoic Acid, a Homologue of Enolpyruvic Acid.
Authors: POLLARD J. R. , HENDERSON I. M. J. , BUGG T. D. H. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Coupling Reactions. Part 18. Synthesis of Triafulvalene Precursors by “Carbene‐Dimerization” of 1‐Halogeno‐1‐lithiocyclopropanes.
Authors: LAENG C. , MUEHLEBACH M. , NEUENSCHWANDER M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Baeyer—Villiger Oxidation of 6‐Oxotricyclo[3.2.1.02,7]octanes. Regioselective Opening of Push—Pull Substituted Cyclopropanes.
Authors: BRAUN N. A. , STUMPF N. , SPITZNER D. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cationic Aqua Complexes of the C2‐Symmetric trans‐Chelating Ligand (R,R)‐4,6‐Dibenzofurandiyl‐2,2′‐bis(4‐phenyloxazoline). Absolute Chiral Induction in Diels—Alder Reactions Catalyzed by Water‐Tolerant Enantiopure Lewis Acids.
Authors: KANEMASA S. , ODERAOTOSHI Y. , YAMAMOTO H. , TANAKA J. , WADA E. , CURRAN D. P. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Mono‐Fluorinated Quinones by an Unusual SRN1 Reaction: Difluoromethyl Quinones as Substrates.
Authors: GIRAUD A. , GIRAUD L. , CROZET M. P. , VANELLE P. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Fluorinated Biphenyls from Aromatic Arylations with Pentafluorobenzenediazonium and Related Cations. Competition Between Arylation and Azo Coupling.
Authors: KOSYNKIN D. , BOCKMAN T. M. , KOCHI J. K. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enhanced Nucleophilic Reactivity of a 4‐Lithiophenoxide Ion (II) and Its Application to the Synthesis of a Bis(4‐hydroxyphenyl)methylenecyclopentadiene (IV) and Its Dianion, a Novel Extended Trimethylenemethane Dianion.
Authors: KURATA H. , TANAKA T. , SAUCHI T. , KAWASE T. , ODA M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transformations of Cumulated Aza‐ortho‐xylylenes Generated from 3‐Arylmethylene‐2,1‐benzisothiazoline 2,2‐Dioxides.
Authors: WOJCIECHOWSKI K. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Synthesis of Episulfides and Their Conversion into Alkenes.
Authors: DYBOWSKI P. , SKOWRONSKA A. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Conjugate Addition of Allylic and Prop‐2‐ynylic Alcohols to 3‐Halogeno‐1‐phenylsulfonylprop‐1‐enes; Synthesis and Radical‐Induced Cyclization of 2‐Alkenyloxy‐3‐halogenopropylphenyl Sulfones.
Authors: GIOVANNINI R. , PETRINI M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,6‐Conjugate Addition to o‐Vinylphenyloxazolines, Syntheses of Chuangxinol and 3‐n‐Butylphthalide.
Authors: MARTINEZ M. M. , ONEGA M. G. , TELLADO M. F. , SEIJAS J. A. , VAZQUEZ‐TATO M. P. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Induction in Intramolecular SN2′ Reaction. Enantioselective Synthesis of Cyclopenta[b]benzofuran with Chiral Lithium Alkoxides.
Authors: NISHIYAMA H. , SAKATA N. , MOTOYAMA Y. , WAKITA H. , NAGASE H. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Halogen Atom Transfer Radical Cyclization of N‐Allyl‐N‐benzyl‐2,2‐dihaloamides to 2‐Pyrrolidinones, Promoted by Fe0—FeCl3 or CuCl—TMEDA.
Authors: BENEDETTI M. , FORTI L. , GHELFI F. , PAGNONI U. M. , RONZONI R. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of N‐α‐Styrylcyclopropane‐5‐phenylamino‐1,2,4‐triazoles and Their Conversion to γ‐Butyrolactones.
Authors: LEE K.‐J. , KIM D.‐W. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Synthesis of Chromans for the Preparation of Enantiopure Vitamin E and Analogues.
Authors: TIETZE L. F. , GOERLITZER J. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of 4‐Hydroxy‐3‐substituted, 2H‐1‐Benzopyran‐2‐ones and 2H‐1‐Benzothiopyran‐2‐ones from Carboxylic Esters and Methyl Salicylates or Methyl Thiosalicylate.
Authors: DAVIS S. E. , CHURCH A. C. , TUMMONS R. C. , BEAM C. F. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Spectroscopy of Phosphonate Derivatives of Uracil and Thymine. X‐Ray Crystal Structure of Diethyl 6‐Uracilmethylphosphonate.
Authors: OCHOCKI J. , ERXLEBEN A. , LIPPERT B. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Synthesis of Quinoxaline‐2,3‐diones as NMDA Receptor Antagonists.
Authors: LIN S.‐K. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Macrocyclic Bis(dithiocarbonic ester)s and Bis(thiocarbamate)s from Diethylene, Triethylene, and Tetraethylene Glycols
Authors: FUKUDA N. , TANAKA T. , FUKUYA T. , TAKEDA Y. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of Seven‐Membered Oxacycles Through Ring Expansion of Cyclopropanated Carbohydrates.
Authors: HOBERG J. O. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Application of the Horner—Wadsworth—Emmons Reaction to the Functionalization of Dendrimers: Synthesis of Amino Acid Terminated Dendrimers
Authors: PREVOTE D. , LE ROY‐GOURVENNEC S. , CAMINADE A.‐M. , MASSON S. , MAJORAL J.‐P. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Bis(2,6‐dimesityl‐4‐methylphenyl)phosphaarsene and EPR of Its Radical Anion.
Authors: TSUJI K. , FUJII Y. , SASAKI S. , YOSHIFUJI M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Tin‐Mediated Pummerer Synthesis of Vinyl Stannanes.
Authors: O'NEIL I. A. , SOUTHERN J. M. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Specific C—C Bond Construction by Remote C—H Activation: Synthesis of (‐)‐trans‐Cembranolide.
Authors: TABER. D. F. TABER. D. F. , SONG Y. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Amide Surrogates of Matrix Metalloproteinase Inhibitors: Urea and Sulfonamide Mimics.
Authors: DECICCO C. P. , SENG J. L. , KENNEDY K. E. , COVINGTON M. B. , WELCH P. K. , ARNER E. C. , MAGOLDA R. L. , NELSON D. J. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Conagenin Analogues Modified at 3′‐Carbon Atom.
Authors: KOVACS‐KULYASSA A. , HERCZEGH P. , SZTARICSKAI F. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enzymic Hydrolysis of Methyl 2,3‐Di‐O‐acetyl‐5‐deoxy‐α and β‐D‐xylofuranosides — An Active‐Site Model of Pig Liver Esterase.
Authors: MORAVCOVA J. , VANCLOVA Z. , CAPKOVA J. , KEFURT K. , STANEK J. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: UDP‐N‐Acetyl‐5‐thio‐galactosamine is a Substrate of Lactose Synthase.
Authors: TSURUTA O. , SHINOHARA G. , YUASA H. , HASHIMOTO H. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Addition of Malonates to Glycals: A General and Convenient Method for the Synthesis of 2‐C‐Branched Carbohydrates.
Authors: LINKER T. , SOMMERMANN T. , KAHLENBERG F. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regiospecific Synthesis of 6‐Alkyltropan‐2‐ones.
Authors: LOMENZO S. A. , BRADLEY A. L. , ZHU N. , KLEIN C. L. , TRUDELL M. L. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of 2,6‐Dimethylergolin‐8α‐amines.
Authors: WALDVOGEL E. , ENGELI P. , KUESTERS E. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Design and Implementation of an Efficient Synthetic Approach to Pyranosylated Indolocarbazoles: Total Synthesis of (+)‐RK286c, (+)‐MLR‐52, (+)‐Staurosporine, and (‐)‐TAN‐1030a.
Authors: WOOD J. L. , STOLTZ B. M. , GOODMAN S. N. , ONWUEME K. 
Published: July 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.