bluuebunny/crossref_metadata_2025_split huggingface dataset:
DOMINANT RISK FACTORS FOR THE INCIDENCE OF “ACUTE RESPIRATORY INFECTION” “ARI” IN TODDLERS
Authors: Ginting Johannes Bastira , Anggraini Nazila , Syukriyah Syaputri Pasaribu Bella , Nur Rehan , Buenita Buenita 
Published: June 2024

Background: Acute Respiratory Infection (ARI) is a contagious illness affecting diverse age groups, including toddlers, and is among the top ten reasons for Community Health Center visits. Purpose: This study aims to analyze the influence of dominant risk factors on the incidence of ARI in toddlers. Methods: This study used an observational, analytic-cross sectional approach, at Puskesmas Kampung Lalang, Medan, in 2023. The total population was 394 toddlers (aged 0-59 months). In the determination of the number of samples using the sample size estimation formula, 198 samples were obtained by purposive sampling. Data analysis used Chi-Square test and Multiple Logistic Regression Enter Methods, with a significance level of 95%. Results: The results showed that the variables of Vitamin A administration (OR = 0.27, 95% CI: 0.10-0.77) and immunization status (OR = 0.36, 95% CI: 0.14-0.93) were associated with a decreased risk of ARI in toddlers. In contrast, exclusive breastfeeding (OR = 2.35, 95% CI: 1.11-5.01) was associated with increased risk, while the physical environment of the house (OR = 2.92, 95% CI: 1.28-6.64) was associated with increased risk of ARI. Conclusion: Vitamin A administration and immunization reduce the risk of respiratory tract infection among under-fives at Puskesmas Kampung Lalang. Exclusive breastfeeding and home conditions increased the same risk. Improving these risk factors is essential to reduce the prevalence of childhood respiratory infections in the area.
Immunotherapy in HIV-associated Kaposi Sarcoma: Challenges and
Prospects
Authors: Tawana Tiiso , du Plessis Julianne , Omar Aadilah 
Published: June 2024

Abstract:
Kaposi Sarcoma [KS] stems from malignant endothelial cells targeting the cutaneous and
lymphatic systems. The aetiological agent, human herpesvirus type 8, has been implicated in the induction
of KS. Of the four variants of KS that exist, HIV/AIDS associated KS remains one of the
leading cancers in people living with HIV in sub-Saharan Africa [SSA]. It is estimated that approximately
80% of KS cases were attributed to HIV in 2020. Although the introduction of anti-retroviral
therapy [ART] alleviated the burden in 1981, its prevalence on the continent remains significant in
comparison to the rest of the world. Traditional therapeutics such as chemotherapy continue to be the
most common form of managing HIV-associated KS; however, the incidence of this global cancer
continues to rise, predominantly in SSA. Furthermore, a significant number of HIV/AIDS-associated
KS patients had been observed with normal CD4+ count and low viral load levels. This necessitates
the development of other therapeutic strategies to collectively manage the continental crisis. Various
strategies, such as immunomodulatory agents, monoclonal antibodies and therapeutic cytokines, are
being investigated to be used as potential therapeutic strategies. One strategy highlights targeting the
signalling pathways and growth factors involved in angiogenesis, which is an important characteristic
of KS. The PD-1/PD-L1 immune checkpoint blockades are particularly interesting since cell cycle
inhibitors have shown promising results as a potential immunotherapeutic agent. Predictive biomarkers
and alternative vaccines will be discussed here while potential barriers which reduce the
impact of immunotherapy are discussed throughout the review.
Identification of Novel Inhibitors for ERα Target of Breast Cancer By In Silico Approach
Authors: Alagarsamy Veerachamy , Sulthana Mohaideen Thasthagir , Narendhar Bandi , Solomon Viswas Raja , Gobinath Manavalan , Satishchandra Aithamraju , Sangeetha Dubudam , Murugesan Sankaraanarayanan 
Published: June 2024

Background:
Estrogen alpha has been recognized as a perilous factor in breast cancer
cell proliferation and has been proficiently treated in breast cancer chemotherapy with the development
of selective estrogen receptor modulators (SERMs).

Objectives:
The major aim of this study was to identify the potential inhibitors against the most
influential target ERα receptor by in silico studies of 115 phytochemicals from 17 medicinal
plants using in silico molecular docking studies.

Methods:
The molecular docking investigation was carried out by a genetic algorithm using the
Auto Dock Vina program, and the validation of docking was also performed using molecular
dynamic (MD) simulation by the Desmond tool of Schrödinger molecular modeling. The ADME(
T) studies were performed by SWISS ADME and ProTox-II.

Results:
The top ten highest binding energy phytochemicals identified were amyrin acetate (-
10.7 kcal/mol), uscharine (-10.5 kcal/mol), voruscharin (-10.0 kcal/mol), cyclitols (-10.0
kcal/mol), taraxeryl acetate (-9.9 kcal/mol), amyrin (-9.9 kcal/mol), barringtogenol C (-9.9
kcal/mol), calactin (-9.9 kcal/mol), 3-beta taraxerol (-9.8 kcal/mol), and calotoxin (-9.8
kcal/mol). A molecular docking study revealed that these phytochemical constituents showed
higher binding affinity compared to the reference standard tamoxifen (-6.6 kcal/mol) towards
the target protein ERα. The results of MD studies showed that all four tested compounds possess
comparatively stable ligand-protein complexes with ERα target as compared to the tamoxifen-
ERα complex.

Conclusion:
Among the ten compounds, phytochemical amyrin acetate (triterpenoids) formed a
more stable complex as well as exhibited greater binding affinity than standard tamoxifen.
ADMET studies for the top ten phytochemicals showed a good safety profile. Additionally, these
compounds are being reported for the first time in this study as possible inhibitors of ERα for
the treatment of breast cancer by adopting the concept of drug repurposing. Hence, these phytochemicals
can be further studied and can be used as a parent core molecule to develop novel
lead molecules for breast cancer therapy.
Persuasive Systems Design Trends in Coronary Heart Disease Management: Scoping Review of Randomized Controlled Trials
Authors: Agyei Eunice Eno Yaa Frimponmaa , Ekpezu Akon , Oinas-Kukkonen Harri 
Published: June 2024

Background
Behavior change support systems (BCSSs) have the potential to help people maintain healthy lifestyles and aid in the self-management of coronary heart disease (CHD). The Persuasive Systems Design (PSD) model is a framework for designing and evaluating systems designed to support lifestyle modifications and health behavior change using information and communication technology. However, evidence for the underlying design principles behind BCSSs for CHD has not been extensively reported in the literature.

Objective
This scoping review aims to identify existing health BCSSs for CHD, report the characteristics of these systems, and describe the persuasion context and persuasive design principles of these systems based on the PSD framework.

Methods
Using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines, 3 digital databases (Scopus, Web of Science, and MEDLINE) were searched between 2010 to 2022. The major inclusion criteria for studies were in accordance with the PICO (Population, Intervention, Comparison, and Outcome) approach.

Results
Searches conducted in the databases identified 1195 papers, among which 30 were identified as eligible for the review. The most interesting characteristics of the BCSSs were the predominant use of primary task support principles, followed by dialogue support and credibility support and the sparing use of social support principles. Theories of behavior change such as the Social Cognitive Theory and Self-Efficacy Theory were used often to underpin these systems. However, significant trends in the use of persuasive system features on par with behavior change theories could not be established from the reviewed studies. This points to the fact that there is still no theoretical consensus on how best to design interventions to promote behavior change in patients with CHD.

Conclusions
Our results highlight key software features for designing BCSSs for the prevention and management of CHD. We encourage designers of behavior change interventions to evaluate the techniques that contributed to the success of the intervention. Future research should focus on evaluating the effectiveness of the interventions, persuasive design principles, and behavior change theories using research methodologies such as meta-analysis.
Pengaturan Tindak Pidana Aborsi, Studi Perbandingan Hukum Pidana Indonesia dan Jepang
Authors: Tri Saputra Kurniawan , Liyus Herry , Wahyudhi Dheny 
Published: June 2024

This article aims to find out and analyze the comparison of legal arrangements regarding the legality of the criminal act of abortion regulated in the laws of Indonesia and Japan. The research methode used in this research is normative juridicial, using statute, conceptual, and comparative law approaches. This research found several that there are a number of similarities and differences in the legality of abortion arrangements in the two countries, in Indonesia, abortion is only allowed on the basis of medical reasons, and pregnancy due to rape with a gestational age limit of 6 weeks, with the provisions of criminal liability which are thoroughly regulated in Undang-Undang Nomor 36 Tahun 2009 Tentang Kesehatan. Meanwhile in Japan, abortion can be carried out on the basis of socio-economic (financial) issues and can be performed up to 22 weeks of gestation with more varied provisions for criminal liability but which are regulated in various legal provisions, namely: Maternal Protection Act 1996, Japan Penal Code and Circular of the Deputy Minister of Health, Welfare and Employment of Japan Number 122 of 1996. It is hoped that with the legal reform regarding the gestational age limit for abortion in Indonesia, it can accommodate the better readiness of pregnant women who will carry out abortion procedures both psychologically, medically, and legally.
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Abstrak
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Artikel ini bertujuan untuk mengetahui dan menganalisis perbandingan pengaturan hukum tentang legalitas tindak pidana aborsi yang diatur dalam hukum negara Indonesia dan Negara Jepang. Metode penelitian yang digunakan dalam penelitian ini adalah yuridis normatif dengan menggunakan pendekatan perundang-undangan, konseptual dan perbandingan hukum.Â Hasil penelitian menunjukkan terdapat sejumlah persamaan maupun perbedaan pengaturan legalitas aborsi di kedua negara, di Indonesia perbuatan aborsi hanya diperbolehkan atas dasar alasan medis, dan kehamilan akibat perkosaan dengan batas waktu usia kehamilan 6 minggu, dengan ketentuan pertanggungjawaban pidana yang secara menyeluruh di atur dalam Undang-Undang Nomor 36 Tahun 2009 Tentang Kesehatan. Sedangkan di Jepang, aborsi dapat dilakukan atas dasar isu sosial-ekonomi (finansial) dan dapat dilakukan hingga usia kehamilan 22 minggu dengan ketentuan pertanggungjawaban pidana yang lebih variatif namun yang diatur dalam berbagai ketentuan hukum, yaitu: Maternal Protection Act 1996, Japan Penal Code dan Surat Edaran Wakil Menteri Kesehatan, Kesejahteraan dan Ketenagakerjaan Jepang Nomor 122 Tahun 1996. Diharapkan dengan adanya pembaruan hukum mengenai batas waktu usia kehamilan untuk melakukan aborsi di Indonesia dapat mengakomodir kesiapan ibu hamil yang akan melakukan prosedur aborsi baik secara psikis, medis, maupun hukum yang lebih baik.
Dasar Pertimbangan Hakim Dalam Menjatuhkan Pidana Terhadap Pelaku Tindak Pidana Korupsi Yang Dilakukan Bersama-Sama
Authors: Ar El Firsta Nopsiamti , Rakhmawati Dessy 
Published: June 2024

This article aims to find out the basic considerations of judges in convicting perpetrators of corruption jointly between Court Decision Number 5/Pid.Sus.Tpk/2021 PN.Jmb and Decision Number 6/Pid.Sus.TPK/2021. PN. Jmb. Corruption is classified as an extraordinary crime because of its extraordinary impact, not only damaging public finances and disrupting social stability and security, but also destroying democratic values and legal certainty. This paper uses a normative juridical research method. The results of this study are the Basis for Judges' Considerations in imposing criminal sanctions on perpetrators of Corruption Crimes which are committed jointly (Analysis of Court Decisions Number 5/Pid.Sus.Tpk/2021 PN.Jmb and Decision Number 6/Pid.Sus.TPK/ 2021. PN.Jmb, the Judge considered in Decision Numbers 05/PID.SUS-TPK/2021/PN.Jmb and 06/PID.SUS-TPK/2021/PN.Jmb namely juridical considerations; the prosecutor's indictment, the statements of the accused and witnesses, evidence, and articles Non-juridical considerations, namely the background to the defendant's actions, the defendant's personal condition, the things
Abstrak
Artikel ini bertujuan untuk mengetahui dasar pertimbangan hakim dalam menjatuhkan pidana terhadap pelaku tindak pidana korupsi secara Bersama-sama antara Putusan Pengadilan Nomor 5/Pid.Sus.Tpk/2021 PN.Jmb dan Putusan Nomor 6/Pid.Sus.TPK/2021. PN. Jmb. Korupsi digolongkan sebagai kejahatan luar biasa (extra ordinary crime) dikarenakan dampaknya yang luar biasa, tidak hanya merusak keuangan publik dan mengganggu stabilitas dan keamanan sosial, tetapi juga merusak nilai-nilai demokrasi dan kepastian hukum..Penulisan ini menggunakan metode penelitian yuridis normatif. Hasil penelitian ini adalah Dasar Pertimbangan Hakim dalam menjatuhkan sanksi pidana terhadap pelaku tindak pidana Korupsi Yang Dilakukan Secara Bersama-sama (Analisis Putusan Pengadilan Nomor 5/Pid.Sus.Tpk/2021 PN.Jmb dan Putusan Nomor 6/Pid.Sus.TPK/2021. PN. Jmb, Hakim mempertimbangkan dalam Putusan Nomor 05/PID.SUS-TPK/2021/PN.Jmb dan 06/PID.SUS-TPK/2021/PN.Jmb yaitu pertimbangan yuridis; dakwaan JPU, keterangan terdakwa dan saksi, barang bukti, dan pasal- pasal. Pertimbangan non yuridis yaitu yang melatar belakangi perbuatan terdakwa, kondisi diri terdakwa, hal-hal yang memberatkan terdakwa.
Tindak Pidana Penipuan Melalui Aplikasi Digital (Gagasan Pemikiran Pertanggungjawaban Oleh Bank)
Authors: Elisa Putri Dina , Sudarti Elly , Siregar Elizabeth 
Published: June 2024

The aim of this research is 1) to determine and analyze the regulations for criminal acts of fraud through digital applications, and 2) the form of bank criminal liability for criminal acts of fraud through digital applications. The type of research is normative juridical. The research results show that regulation of criminal acts of fraud through digital applications can be guided by Article 492 and Article 263 of the new Criminal Code as well as Article 28 paragraph (1) of the ITE Law. However, in the regulation there is still a blurring of norms because Article 378, Article 492 and Article 263 of the Criminal Code as well as Article 28 paragraph (1) of the ITE Law also do not specifically emphasize the proportion of "fraud", especially for fraud that is not related to buying and selling. The form of bank accountability for criminal acts of fraud through digital applications can be carried out by providing protection to customers by providing implicit protection through supervision and explicit protection through the establishment of an institution that guarantees public savings. Furthermore, the bank has the responsibility to provide compensation to customers who experience losses if technical errors or leakage of bank customer data occurs due to negligence on the part of the Bank.

ABSTRAKTujuan dari penelitian ini adalah 1) untuk mengetahui dan menganalisis pengaturan terhadap tindak pidana penipuan melalui aplikasi digital, dan 2) bentuk pertanggungjawaban pidana bank atas tindak pidana penipuan melalui aplikasi digital. Jenis penelitian adalah yuridis normative. Hasil penelitian menunjukkan bahwa pengaturan terhadap tindak pidana penipuan melalui aplikasi digital dapat berpedoman pada Pasal 492 dan Pasal 263 KUHP baru maupun dalam Pasal 28 ayat (1) UU ITE. Akan tetapi dalam pengaturannya masih terjadi kekaburan norma karena dalam Pasal 378, Pasal 492 dan Pasal 263 KUHP maupun dalam Pasal 28 ayat (1) UU ITE tersebut juga tidak menegaskan proporsi “penipuan” secara spesifik, terutama untuk penipuan yang tidak berkaitan dengan jual beli. Bentuk pertanggungjawaban bank atas tindak pidana penipuan melalui aplikasi digital dapat dilakukan dengan memberikan perlindungan terhadap nasabah dengan melakukan perlindungan secara implicit melalui pengawasan dan perlindungan secara eksplisit melalui pembentukan suatu lembaga yang menjamin simpanan masyarakat. Se;anjutnya pihak bank memilki tanggung jawab untuk melakukan ganti rugi terhadap nasabah yang mengalami kerugian jika kesalahan teknis atau bocornya data nasabah bank terjadi karena kelalaian dari pihak Bank.
Johann George Schreiber’s Atlas selectus: new findings
Authors: Paprotny Zbigniew 
Published: June 2024

Abstract
This update to the earlier paper on Schreiber’s Atlas selectus (Paprotny, 2020) presents new findings supplementing and specifying information about the Atlas, its editions, dating, and maps. Discussed are recently discovered prototype versions of the Atlas which preceded series of “canonical” editions, and status of post-1795 copies. An updated list of 32 Atlas editions known today has been compiled, together with catalogue of its maps, identifying their occurrence in the individual editions. Corrections to Jäger’s catalogue of maps from Schreiber’s workshop are proposed.
Factors that Influence Electric Vehicle Purchase Intention: an Evidence from Indonesia
Authors: Eryolanda Emiliana Indri , Sukanto Alim Gunadi , Teasari Indah , Mahyudi Andry , Purnomo Ariyadi Yudo , Istijanto Istijanto 
Published: June 2024

Electric vehicles (EV) are new products that will replace conventional vehicles. Previous studies on factors influencing EVs purchase intention rarely includes the impact of social media factors. This study aims to build a comprehensive model examining factors that influence consumer intention to purchase EVs. Based on the theory of reasoned action and risk-benefit model, this study incorporates social media relevance, vendor trustworthiness, vendor expertise, social influence, and perceptions of EV benefits and risks. Data is collected through online surveys. 295 data were obtained and analyzed by exploratory factor analysis and multiple regression using SPSS. The results show that perceived relevance to social media has the greatest influence on EV purchase intention, followed by perceived benefits and risks, social influence, and vendor expertise, while vendor trustworthiness didn’t have a significant impact. This study’s result contributes to the knowledge of EV buying factors and offers managerial implications for EV providers’ business strategy.
Keyword: factor, purchase intention, social media, theory of reasoned action, electric vehicle
Integrated Neuromuscular Inhibition Technique Lebih Efektif daripada Muscle Energy Technique pada Penderita Non-Specific Neck Pain
Authors: Sudaryanto Sudaryanto , Suharto Suharto , Hasbiah Hasbiah , Khaerah Ummatul 
Published: June 2024

Pendahuluan: Nyeri leher yang tidak spesifik biasanya disebabkan oleh kegiatan yang dilakukan mahasiswa, seperti menggunakan tas punggung, komputer, dan handphone dalam jangka waktu yang lama. Gejalanya sering kali muncul dari facet joint, otot upper trapezius, levator scapula, dan splenius capitis, yang menyebabkan terbatasnya gerakan lateral fleksi dan rotasi cervical.
Metode: Penelitian ini merupakan quasi eksperimen dengan desain randomized control group pre test-post test, yang bertujuan untuk mengevaluasi perbedaan efektivitas antara Teknik Inhibisi Neuromuskular Terintegrasi (INIT) dan Teknik Energi Otot (MET) terhadap perubahan rentang gerak sendi cervical pada individu yang mengalami nyeri leher non-spesifik. Dua kelompok sampel terbentuk: kelompok perlakuan menerima intervensi INIT dan kelompok kontrol menerima MET. Kedua kelompok juga diberi intervensi Ultrasound. Penelitian ini dilakukan di klinik Fisioterapi Mabbulosibatang dengan melibatkan 30 mahasiswa yang memenuhi kriteria inklusi melalui prosedur pemeriksaan non-spesifik neck pain, kemudian mereka diacak menjadi 2 kelompok. Pengumpulan data menggunakan inclinometer untuk mengukur Rentang Gerak (ROM) lateral fleksi dan rotasi cervical pada tahap pre-test awal dan post-test akhir penelitian.
Hasil: Analisis paired t-test menunjukkan nilai p=0,000 untuk gerakan lateral fleksi dan rotasi pada kelompok perlakuan dan kontrol, menunjukkan adanya pengaruh yang signifikan dari intervensi INIT dan MET terhadap perubahan rentang gerak sendi cervical. Hasil independent t-test menunjukkan nilai p=0,029 untuk lateral fleksi dan p=0,014 untuk rotasi, menunjukkan perbedaan efektivitas yang signifikan antara INIT dan MET.
Simpulan: Teknik Inhibisi Neuromuskular Terintegrasi (INIT) secara signifikan lebih efektif daripada Teknik Energi Otot (MET) terhadap perubahan rentang gerak sendi cervical pada individu yang mengalami nyeri leher non-spesifik.

Kata kunci : integrated neuromuscular inhibition technique, muscle energy technique, lingkup gerak sendi cervical, non-specific neck pain
Tingkat Intensitas Penggunaan Smartphone dengan Keluhan Carpal Tunnel Syndrome pada Remaja
Authors: Barani Made Donna Safira Pitaloka , Thanaya Sayu Aryantari Putri , Widnyana M. , Dewi Ni Nyoman Ayu 
Published: June 2024

Pendahuluan: Carpal Tunnel Syndrome (CTS) ialah kondisi yang timbul karena kompresi saraf median pada lorong karpal. Peningkatan intensitas penggunaan smartphone dapat mempengaruhi struktur terowongan karpal dikarenakan penggunaan jari berlebih saat menggunakan smartphone yang dapat membebani sendi atau otot tangan hingga berujung pada penekanan saraf median. Tujuan penelitian ini untuk membahas korelasi intensitas penggunaan smartphone dalam memicu keluhan carpal tunnel syndrome pada remaja di SMA Negeri 1 Semarapura.
Metode: Metode penelitian ini, yaitu analitik observasional dengan pendekatan potong lintang (cross-sectional). Teknik pengambilan sampel berupa purposive sampling. Jumlah sampel sebanyak 62 orang dengan rentang usia 15-17 tahun. Data penelitian yang dikumpulkan berupa penggunaan smartphone yang diukur menggunakan kuesioner intensitas penggunaan smartphone dan keluhan carpal tunnel syndrome yang diukur menggunakan carpal tunnel syndrome questionnaire.
Hasil: Hasil menunjukkan bahwa terdapat 61 (98,4%) sampel yang mengeluhkan CTS dengan keluhan ringan dan 1 (1,6%) sampel mengeluhkan keluhan sedang. Frekuensi penggunaan smartphone pada sampel digolongkan menjadi 12 orang (19,4%) dengan intensitas sedang dan 50 orang (80,6%) dengan intensitas tinggi. Uji hipotesis rank spearman digunakan untuk menganalisis hubungan intensitas penggunaan smartphone dengan keluhan CTS dan didapatkan nilai p sebesar 0,628 yang menunjukkan hubungan searah antara intensitas penggunaan smartphone dengan keluhan CTS.
Simpulan: Tidak terdapat hubungan yang signifikan antara intensitas penggunaan smartphone dengan keluhan CTS pada remaja di SMA Negeri 1 Semarapura namun terjadi keluhan CTS pada seluruh siswa yang menunjukkan perlunya perhatian khusus terkait penggunaan smartphone dengan kejadian CTS.

Kata Kunci: intensitas, smartphone, carpal tunnel syndrome