bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring specific antibody responses against the hydrophilic domain of the 23 kDa membrane protein of Schistosoma japonicum for early detection of infection in sentinel mice
Authors: Wang Jie , Yu Chuan-Xin , Yin Xu-Ren , Zhang Wei , Qian Chun-Yan , Song Li-Jun , Ke Xue-Dan , Xu Yong-Liang , He Wei , Cao Guo-Qun 
Published: September 2011

AbstractBackgroundSchistosomiasis remains an important public health problem throughout tropical and subtropical countries. Humans are infected through contact with water contaminated with schistosome cercariae. Therefore, issuing early warnings on the risk of infection is an important preventive measure against schistosomiasis. Sentinel mice are used to monitor water body infestations, and identifying appropriate antibody responses to schistosome antigens for early detection of infection would help to improve the efficiency of this system. In this study we explored the potential of detecting antibodies to the hydrophilic domain (HD) of the 23-kDa membrane protein (Sj23HD) and soluble egg antigen (SEA) ofSchistosome japonicumfor early detection of schistosome infection in sentinel mice.ResultsDevelopment of IgM and IgG antibody levels against Sj23HD and SEA inS. japonicuminfected mice was evaluated over the course of 42 days post-infection by enzyme-linked immunosorbent assay (ELISA) and immunoblotting. The Sj23HD and SEA specific IgM and IgG levels in mice all increased gradually over the course of infection, but IgM and IgG antibodies against Sj23HD presented earlier than those against SEA. Furthermore, the rates of positive antibody responses against Sj23HD were higher than those against SEA in the early stage of schistosome infection, suggesting that the likelihood of detecting early infection using anti-Sj23HD responses would be higher than that with anti-SEA responses. The use of immunoblotting could further improve the early detection of schistosome infection due to its greater sensitivity and specificity compared to ELISA. Additionally, the levels of Sj23HD and SEA specific antibodies positively correlated with the load of cercariae challenge and the duration of schistosome infection.ConclusionsThis study demonstrated that antibody responses to the Sj23HD antigen could be monitored for early detection of schistosome infection in mice, especially by immunoblotting which demonstrated greater sensitivity and specificity than ELISA for detection Sj23HD antibodies.
Novel Alkyl Polyglucoside Surfactant Derivatives for Improving the Infiltration of Irrigation Water into Repellent Soil
Authors: Bially Paul T. 
Published: September 2011

Abstract
Soil water repellency causes several agronomic challenges for turfgrass managers, such as reduced color, quality, and playability of golf courses and sports fields. Surfactants are commonly applied as water and soil treatments in order to manage water conservation, irrigation efficiency, and overall plant health. There is an ongoing need within the current sustainability initiatives for advanced materials with superior environmental and performance profiles. This research is the first to demonstrate the efficacy of anionic alkyl polyglucoside esters (AGEs) and AGE-nonionic surfactant blends in increasing the wettability of naturally derived and artificially repellent mineral soils. Surfactant compositions were diluted in distilled water to concentrations ranging from 8000 mg l−1 to 500 mg l−1. A standardized water droplet penetration test was used to measure infiltration times into soils of varying degrees of repellency. AGEs were up to 10 times more effective than alternative surfactants at improving water movement into soil. Performance differences became more significant as the application rates decreased. Our results demonstrate that AGEs can be highly effective at delivering irrigation water and aqueous compositions into the root zone of turfgrass when applied alone and/or in concert with traditional wetting agent classes. Patent applications have been submitted for this discovery.
Incidence of hyperthyroidism in Sweden
Authors: Abraham-Nordling Mirna , Byström Kristina , Törring Ove , Lantz Mikael , Berg Gertrud , Calissendorff Jan , Nyström Helena Filipsson , Jansson Svante , Jörneskog Gun , Karlsson F Anders , Nyström Ernst , Ohrling Hans , Örn Thomas , Hallengren Bengt , Wallin Göran 
Published: September 2011

IntroductionThe incidence of hyperthyroidism has been reported in various countries to be 23–93/100 000 inhabitants per year. This extended study has evaluated the incidence for ∼40% of the Swedish population of 9 million inhabitants. Sweden is considered to be iodine sufficient country.MethodsAll patients including children, who were newly diagnosed with overt hyperthyroidism in the years 2003–2005, were prospectively registered in a multicenter study. The inclusion criteria are as follows: clinical symptoms and/or signs of hyperthyroidism with plasma TSH concentration below 0.2 mIE/l and increased plasma levels of free/total triiodothyronine and/or free/total thyroxine. Patients with relapse of hyperthyroidism or thyroiditis were not included. The diagnosis of Graves' disease (GD), toxic multinodular goiter (TMNG) and solitary toxic adenoma (STA), smoking, initial treatment, occurrence of thyroid-associated eye symptoms/signs, and demographic data were registered.ResultsA total of 2916 patients were diagnosed withde novohyperthyroidism showing the total incidence of 27.6/100 000 inhabitants per year. The incidence of GD was 21.0/100 000 and toxic nodular goiter (TNG=STA+TMNG) occurred in 692 patients, corresponding to an annual incidence of 6.5/100 000. The incidence was higher in women compared with men (4.2:1). Seventy-five percent of the patients were diagnosed with GD, in whom thyroid-associated eye symptoms/signs occurred during diagnosis in every fifth patient. Geographical differences were observed.ConclusionThe incidence of hyperthyroidism in Sweden is in a lower range compared with international reports. Seventy-five percent of patients with hyperthyroidism had GD and 20% of them had thyroid-associated eye symptoms/signs during diagnosis. The observed geographical differences require further studies.
Intensive management of electrical storm and incessant ventricular arrhythmias
Authors: Zima Endre 
Published: September 2011

Abstract
Electrical storm (ES) is defined as ventricular tachycardia or ventricular fibrillation occurring at least three times in 24 h leading to hemodynamic unstable state that needs cardioversion or defibrillation. ES may cause fast hemodynamic impairment, leading to “low-perfusion” or “no perfusion” state of the organs, a vicious circle pointing toward cardiogenic shock, multi-organ failure, and pulseless electrical activity. ES in ICD patients may be a strong predictor of arrhythmic and nonarrhythmic death, as well as of rehospitalization. The first step is to start cardiopulmonary resuscitation to achieve complete hemodynamic stabilization to prevent the low-flow or no-flow state. The patient has to be transported to an intensive care unit for further specific treatment. The arrhythmia should be treated with specific antiarrhythmic agents, for example, amiodarone, lidocain and bretylium, and then all the reversible causes have to be detected and treated as fast as possible. Underlying heart disease determines the specific treatment such as coronary revascularization, mechanical circulatory and respiratory support, and ablation of the arrhythmic foci.
Serotonin and hydroxyindolacetic acid levels in aqueous humor of patients with primary open-angle glaucoma
Authors: Ghanem Asaad A. , Mady Salah M. , Arafa Lamiaa F. , Elewa Ahmed M. 
Published: September 2011

AbstractPurposeTo investigate the levels of 5-HT (serotonin, 5-hydroxytryptamine) and 5-HIAA (5-hydroxyindolacetic acid) in the aqueous humor and plasma of subjects with primary open-angle glaucoma (POAG) and to correlate their concentrations with the severity of glaucoma.MethodsThirty-five patients with POAG and 30 patients with senile cataract (control group) of matched age and gender were included in the study prospectively. Aqueous humor samples were obtained by paracentesis from glaucoma and cataract patients who were undergoing elective surgery. Aqueous humor and corresponding plasma samples were analyzed for 5-HT and 5-HIAA levels by high performance liquid chromatography with electrochemical detection.Results5-HT and 5-HIAA levels were significantly higher in the aqueous humor of POAG patients than in that of the comparative group of cataract patients. There was no significant difference in the 5-HT and 5-HIAA levels in plasma of POAG and cataract patients. A positive correlation was found between 5-HT and 5-HIAA in the aqueous humor of POAG patients. The 5-HT turnover (5-HIAA/5-HT) was higher in POAG than in cataract patients, but the difference was not significant. No significant correlation was found between levels and severity of visual field loss.ConclusionIncreased levels of 5-HT and 5-HIAA aqueous humor may be associated with POAG.
Ruptured abdominal aortic aneurysm: Endovascular treatment
Authors: Ukovich Laura , Nikolakopoulos Konstantinos , Biasion Christian , Cera Chiara , Mucelli Fabio Pozzi , Chiarandini Stefano , Adovasio Roberto 
Published: September 2011

Abstract

Aim
The elective endovascular treatment of abdominal aortic aneurysm (AAA) is nowadays a daily routine practice in selected patients. The traditional treatment of ruptured abdominal aortic aneurysm (rAAA) has a peri-operative mortality of 40–50% that has not changed in the last 20 years. Nowadays, the endovascular repair may reduce mortality, hospitalization and sanitary costs.

Methods
The study included 14 patients affected by AAA who came to the Emergency Department because of hemodynamic shock (nine patients) or back pain (five patients). All patients underwent a CT angiography before surgery. Forty-two percent of the patients presented with shock (systolic pressure ≤70 mm Hg) in the operating room, and they underwent an endovascular aortic repair (EVAR) as an emergency procedure. Five bifurcated endoprotesis and nine uniliac protesis making a femoro-femoral bypass to revascularize the excluded limb were made. Patients underwent a follow up with CT angiography one month and then six months after surgery and if no problems were detected, patients underwent a follow-up every year.

Results
Two cases were immediately converted to open surgery because of failed EVAR. Four patients (28%) died after surgery because of multi-organ failure (MOF). The mean hospitalization was 12 days (range 3–21 days). We observed only one case of first-type endoleak at the 1-month follow up and we successfully treated it with a proximal cuff.

Conclusion
In our experience, the intention-to-treat protocol for rAAA offered acceptable results in terms of mortality rates. Multicenter studies are necessary to establish the role of endovascular treatment in patients with rAAA.
Characterization, comparative genomics, and evolutionary inferences of a human drug metabolizing (NAT2) gene
Authors: Khan Naazneen , Pande Veena , Das Aparup 
Published: September 2011

Abstract

Aim
The present-day genetic architecture of a species bears much significance to its closely related species. In recent availability of whole genome sequence data for closely related species, it is possible to detect genetic similarities/differences in specific lineages and infer the role of evolutionary forces in bringing such similarities/differences. In this respect, NAT2 gene, responsible for drug metabolism, is conserved across a few taxa and, thus, comparative genomic studies could be useful for better pharmacogenetic realization.

Methods
DNA sequences of human NAT2 gene were retrieved from NCBI and characterized. Comparative and evolutionary analyses were performed with sequences from four mammalian taxa and one avian taxon with different statistical algorithms.

Results
The observed genetic architecture of NAT2 gene was different across the taxa. Phylogenetic inferences revealed that human and chimpanzee are diverged recently and fowl was found to be diverged from rest of the taxa significantly. Also, gene length, microsatellites, Ka/Ks, secondary structure, and distribution of CpG islands were observed across taxa.

Conclusions
The detail architecture of NAT2 gene and its evolutionary history in different taxa show relationships with other taxa. Future population-based study in NAT2 would unravel the correlation between nucleotide changes and differential ability of drug metabolization in humans.
Radiofrequency ablation of multifocal bilateral renal oncocytomas
Authors: Krokidis Miltiadis , Sabharwal Tarun , Adam Andreas 
Published: September 2011

Abstract
Renal oncocytoma is a usually benign, typically solitary renal tumor, which cannot be reliably distinguished from other renal neoplasms on the basis of its imaging characteristics. Multifocality and/or bilaterality are very rare; to our knowledge only one case of multiple and/or bilateral oncocytomas is reported in the literature and was treated with partial nephrectomy. We report a case of a 72-year-old patient with multifocal and bilateral renal oncocytomas that were treated with radiofrequency ablation.
Atrial flutter in a newborn
Authors: Femitha P. , Joy Rojo , Bharathi B. , Adhisivam B. , Gane B. D. , Vishnu Bhat B. , Balachander J. 
Published: September 2011

Abstract
Fetal and neonatal arrhythmias present as diagnostic and therapeutic challenges to obstetricians and neonatologists. We present a case of antenatally detected atrial flutter in which the infant presented with congestive cardiac failure at birth and a short review of tachyarrhythmias in the perinatal period.
West Nile virus encephalitis in kidney transplanted patient, first case in Hungary: Case report
Authors: Smudla Anikó , Gerlei Zsuzsanna , Gergely Levente , Varga Marina , Toronyi Éva , Doros Attila , Mándli Tamás , Arányi Zsuzsanna , Bán Enikő , Sárváry Enikő , Kóbori László , Fazakas János 
Published: September 2011

Abstract
The complications caused by the rarely viral infections are more frequently treated in ICU (intensive care unit). The world paid attention to the WNV (West Nile virus) infections only in 1999, when 62 meningoencephalitis were registered in New York State. Six cases of WNV occur annually in Hungary. The authors present the first transplanted Hungarian patient with WNV encephalitis. The patient was hospitalized with epigastric pain, diarrhea, continuous fever, and decreasing amount of urine. The first checkup of infectious diseases was without any result. Although using of empirical antimicrobal therapy, the multiorgan failure patient remained febrile. On the basis of clinical signs, meningitis or encephalitis was suspected despite negative results of repeated cultures. On the 8th day, WNV infection was confirmed by serological examinations. With intravenous immunoglobulin therapy used within confines of supportive treatment, the patient became afebrile. After 21 days in ICU with good graft function, the patient was moved to the ward and he left the hospital after two more weeks. Until now, no prophylactic or etiological treatment has been developed for WNV. The early treatment is done with immunoglobulin or interferon; otherwise therapy has only supportive function. The disease caused by virus is more aggressive in transplanted patients and could be caused death.
Potential influence of the pericardial space on myocardial function: Cardiac interactions of adenosine and endothelin-1
Authors: Nagy Andrea 
Published: September 2011

Abstract
Adenosine (ADO) and endothelin-1 (ET-1) play an important role in the regulation of myocardial functions. The pericardial fluid accumulates these regulatory agents and reflects well their levels in the myocardial interstitium. The aim was to investigate the interaction and cardiovascular effects of ADO and ET-1 evoked from the pericardial space, determine the pericardial elimination of intrapericardially applied adenosine and its first metabolite, inosine (INO) and observe their effects on the cardiovascular function compared to their intravenous administration. The present studies were performed on in situ dog heart using the closed pericardium model. Significant increase of the pericardial concentrations of adenine nucleosides (adenosine and inosine) after intrapericardial administration of ET-1 has been found. Regarding the adenine nucleosides-ET-1 interaction, we have demonstrated ET-1 liberation after intrapericardial administration of adenine nucleosides. The present study confirmed significantly slower elimination of adenine nucleosides in the pericardial space than in the systemic circulation. In conclusion, characteristic cardiovascular effect and bidirectional interaction of adenine nucleosides and ET-1 could be provoked by and detected in the pericardial space, reflecting parallel changes in the myocardial interstitium. The low pericardial turnover rate of adenine nucleosides may offer the opportunity of utilizing their multiple beneficial effects for local pharmaco-therapeutic interventions.
La prolongation de la vie humaine selon Francis Bacon. Ou : quel Tithon voulons-nous être ?
Authors: Weber Dominique 
Published: September 2011

Afin de comprendre avec exactitude la manière dont Francis Bacon envisage la question de la prolongation de la vie humaine, il faut impérativement examiner l’assise théologique de la réflexion du philosophe à ce sujet. Il convient aussi de restituer l’intégration de cette réflexion dans les objectifs plus amples de la philosophie naturelle nouvelle. Enfin, il est nécessaire de comprendre les dimensions proprement morales de la question. Car la prolongation de la vie humaine n’est pas seulement, au sein de la philosophie naturelle nouvelle, un cas parmi d’autres des recherches qu’il faut désormais effectuer : en réalité, c’est elle qui lui donne et qui lui fixe son sens ; avec elle se joue l’effectivité de l’identité espérée entre science et puissance. Mais il faut encore préciser qu’il ne s’agit aucunement pour l’homme de vieillir pour vieillir : il s’agit pour lui de pouvoir vieillir bien. Les leçons que Bacon tire de la fable de Tithon sont ici véritablement décisives.
Stahl et les âges de la vie
Authors: Carvallo Sarah 
Published: September 2011

La vieillesse constitue une pierre de touche pour toute théorie médicale : elle oblige à rendre raison de la temporalité à l’œuvre dans la vie. Aux yeux de Stahl, les iatromécaniciens méconnaissent la dimension temporelle de l’organisme ; en particulier, ils en ignorent la périodicité. Comprendre la vieillesse suppose donc la critique de la représentation linéaire du temps organique, que développe la mécanique et qui réduit le vivant au seul composé physique et chimique. Il reste alors à trouver la cause de la périodicité organique : sur ce point, Georg Ernst Stahl critique Thomas Sydenham, qui reconnaît certes la périodicité du vivant mais nie la possibilité d’une médecine étiologique. Pour sa part, le médecin de Halle cherche à rendre compte du vieillissement en lien avec les actions organiques fondamentales : le tonus, la circulation, l’excrétion, la sécrétion.
Synthèse et conclusions sur la gestion durable des zones côtières et marines. Au-delà des discours, des enjeux opérationnels pour le développement durable ?
Authors: Michelot Agnès 
Published: September 2011

Le colloque de La Rochelle sur la « Gestion durable des zones côtières et marines : nouveaux discours, nouvelles durabilités, nouvelles frontières » des 10 et 11 juin 2010 permet d’aborder les enjeux du développement durable dans les zones côtières et maritimes. Les contributions de juristes, politistes, biologistes et géographes permettent d’établir une approche croisée du concept de gestion intégrée des zones côtières (GIZC) tournée vers la mer. Au gré des discours, des textes juridiques et de l’évolution des connaissances scientifiques, le concept connaît des adaptations qui ouvrent de nouvelles perspectives pour réaliser les objectifs de gestion durable dans une démarche intégrée responsable et ancrée dans des processus participatifs, à plusieurs échelles d’espaces et de temps. Le colloque de La Rochelle amène à découvrir les nouvelles « frontières » du concept de GIZC, c’est-à-dire ses potentialités, ses applications élargies ou redimensionnées, repensées en convergence avec des exigences décisionnelles et d’intervention garantissant son caractère opérationnel dans un contexte global, national ou local particulièrement évolutif.
Myeloma-Induced Alloreactive T Cells Arising in Myeloma-Infiltrated Bones Include Double-Positive CD8+CD4+ T Cells: Evidence from Myeloma-Bearing Mouse Model
Authors: Freeman Lisa M. , Lam Alfred , Petcu Eugene , Smith Robert , Salajegheh Ali , Diamond Peter , Zannettino Andrew , Evdokiou Andreas , Luff John , Wong Pooi-Fong , Khalil Dalia , Waterhouse Nigel , Vari Frank , Rice Alison M. , Catley Laurence , Hart Derek N. J. , Vuckovic Slavica 
Published: September 2011

Abstract
The graft-versus-myeloma (GVM) effect represents a powerful form of immune attack exerted by alloreactive T cells against multiple myeloma cells, which leads to clinical responses in multiple myeloma transplant recipients. Whether myeloma cells are themselves able to induce alloreactive T cells capable of the GVM effect is not defined. Using adoptive transfer of T naive cells into myeloma-bearing mice (established by transplantation of human RPMI8226-TGL myeloma cells into CD122+ cell-depleted NOD/SCID hosts), we found that myeloma cells induced alloreactive T cells that suppressed myeloma growth and prolonged survival of T cell recipients. Myeloma-induced alloreactive T cells arising in the myeloma-infiltrated bones exerted cytotoxic activity against resident myeloma cells, but limited activity against control myeloma cells obtained from myeloma-bearing mice that did not receive T naive cells. These myeloma-induced alloreactive T cells were derived through multiple CD8+ T cell divisions and enriched in double-positive (DP) T cells coexpressing the CD8αα and CD4 coreceptors. MHC class I expression on myeloma cells and contact with T cells were required for CD8+ T cell divisions and DP-T cell development. DP-T cells present in myeloma-infiltrated bones contained a higher proportion of cells expressing cytotoxic mediators IFN-γ and/or perforin compared with single-positive CD8+ T cells, acquired the capacity to degranulate as measured by CD107 expression, and contributed to an elevated perforin level seen in the myeloma-infiltrated bones. These observations suggest that myeloma-induced alloreactive T cells arising in myeloma-infiltrated bones are enriched with DP-T cells equipped with cytotoxic effector functions that are likely to be involved in the GVM effect.
Deletion 2p15–16.1 syndrome: Case report and review
Authors: Prontera Paolo , Bernardini Laura , Stangoni Gabriela , Capalbo Anna , Rogaia Daniela , Romani Rita , Ardisia Carmela , Dallapiccola Bruno , Donti Emilio 
Published: September 2011

AbstractWe report on a 9‐year‐old female patient with facial anomalies and developmental delay, heterozygous for three de novo rearrangements: a paracentric inversion of chromosome 7, an apparently balanced translocation between chromosome 1 and 7, involving the same inverted chromosome 7, detected by standard cytogenetic analysis [46,XX, der(7) inv(7)(q21.1q32.1)t(1;7)(q23q32.1)]; and a 2p16.1 deletion, spanning about 3.5 Mb of genomic DNA, shown by SNP‐array analysis [arr 2p16.1 (56,706,666–60,234,485)x1 dn]. Clinical features and cytogenetic imbalance in our patient were similar to those reported in five published cases, suggesting that this genomic region is prone to recombination and its hemizygosity results in a distinct although variable spectrum of clinical manifestations. © 2011 Wiley‐Liss, Inc.