bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engaging patient and community stakeholders in the optimization of the Compassionate And Loving Mindset towards heart health risk (CALM Hearts) physical activity intervention: a description of initial work and protocol for future engagement activities
Authors: Chudyk Anna Maria , Kullman Sasha , Pool Donna , Duhamel Todd Ashley , Ashe Maureen , Strachan Shaelyn 
Published: May 2024

Abstract
Background
Participatory research approaches systematically integrate the perspectives of individuals, organizations, or communities that have a direct interest in a study’s processes and outcomes (i.e., stakeholders) in research design and implementation. This supports interventions that are developed “by, not for” end-users, thereby increasing acceptability, uptake, and adherence. However, participatory approaches are relatively under-utilized in intervention development and behavioral change intervention research, in part, due to inadequate reporting of methodology. Therefore, to improve transparency in planning and reporting, we (a) describe how we engaged patients and community organizations (i.e., patient and community partners) in grant development for a self-compassion and physical activity behaviour change intervention for women with cardiovascular risk factors and (b) present a protocol for engaging patient and community partners in the optimization and implementation of the intervention moving forward.

Methods
Our participatory research approach was guided by the Strategy for Patient-Oriented Research patient engagement framework and our prior stakeholder engagement work. Four patients and three community partners were engaged at the level of Involve, meaning their perspectives informed directions, processes, and decisions at major project milestones. Specifically, patient and community partners engaged in three separate meetings during grant development wherein they: (a) established a Terms of Reference to guide engagement activities and expectations; (b) shaped the grant through guided conversations about research priorities, outcomes, and intervention delivery components that could be targeted for optimization and (c) co-developed a protocol that specifies how relationships will be initiated with future patient partners, proposes engagement activities across the research cycle, and includes plans for formal evaluation of engagement processes.

Conclusions
Participatory research approaches provide valuable insights into the development of behavioural interventions, especially when stakeholders can partner early and have a meaningful impact. By detailing our engagement activities to date, we hope to model an approach to engaging stakeholders in behavioral intervention development and demonstrate the impacts of doing so.
A multi-agent adaptive deep learning framework for online intrusion detection
Authors: Soltani Mahdi , Khajavi Khashayar , Jafari Siavoshani Mahdi , Jahangir Amir Hossein 
Published: May 2024

AbstractThe network security analyzers use intrusion detection systems (IDSes) to distinguish malicious traffic from benign ones. The deep learning-based (DL-based) IDSes are proposed to auto-extract high-level features and eliminate the time-consuming and costly signature extraction process. However, this new generation of IDSes still needs to overcome a number of challenges to be employed in practical environments. One of the main issues of an applicable IDS is facing traffic concept drift, which manifests itself as new (i.e. , zero-day) attacks, in addition to the changing behavior of benign users/applications. Furthermore, a practical DL-based IDS needs to be conformed to a distributed (i.e. , multi-sensor) architecture in order to yield more accurate detections, create a collective attack knowledge based on the observations of different sensors, and also handle big data challenges for supporting high throughput networks. This paper proposes a novel multi-agent network intrusion detection framework to address the above shortcomings, considering a more practical scenario (i.e., online adaptable IDSes). This framework employs continual deep anomaly detectors for adapting each agent to the changing attack/benign patterns in its local traffic. In addition, a federated learning approach is proposed for sharing and exchanging local knowledge between different agents. Furthermore, the proposed framework implements sequential packet labeling for each flow, which provides an attack probability score for the flow by gradually observing each flow packet and updating its estimation. We evaluate the proposed framework by employing different deep models (including CNN-based and LSTM-based) over the CIC-IDS2017 and CSE-CIC-IDS2018 datasets. Through extensive evaluations and experiments, we show that the proposed distributed framework is well adapted to the traffic concept drift. More precisely, our results indicate that the CNN-based models are well suited for continually adapting to the traffic concept drift (i.e. , achieving an average detection rate of above 95% while needing just 128 new flows for the updating phase), and the LSTM-based models are a good candidate for sequential packet labeling in practical online IDSes (i.e. , detecting intrusions by just observing their first 15 packets).
Challenges faced by a hospital administrator
Authors: Sarla Gurmeet Singh 
Published: May 2024

AbstractA hospital is a very complex organization because it works on all days, at all hours uninterruptedly. The people visiting a hospital are in pain, and the people working in a hospital are diverse ranging from highly skilled medical, paramedical, and technical staff to unskilled employees working as runners, female attendants, and house-keeping staff making it a unique place to be or work in. Hence, a hospital administrator who is at the helm of affairs needs to be mature and tactful in dealing with the staff. A hospital administrator is a professional who oversees the daily operations of a hospital by planning, directing, and coordinating health services. In view of the peculiar nature of the hospital as an organization, the hospital administrator needs to have a multidisciplinary approach applying the principles of public administration, behavioral science, and management skills. He needs to have a balanced approach and find a middle path for multiple issues which are likely to crop up almost daily while working in a hospital. Hospital managers need to possess expertise in the form of strategic skills, perceptive skills, human relation skills, work experience, and personal characteristics in the form of motivation, self-confidence, and courage of decision-making. Hospital administrators should be capable to solve any number of problems quickly and efficiently and must know the best ways to approach a conflict so as not to escalate the situation. The primary focus of hospital administrator is on ensuring high-quality patient care and efficient hospital services and use their administrative skills to manage budgets, funding, and resources.
Digital sleep clinic: assessing efficacy of continuous positive airway pressure through sleep staging via connected devices: a study protocol
Authors: Ben Messaoud Raoua , Baillieul Sébastien , Tamisier Renaud , Terrail Robin , Bailly Sébastien , Joyeux-Faure Marie , Pépin Jean-Louis 
Published: May 2024

Abstract
Background
Obstructive sleep apnea (OSA) is a multisystemic chronic disease with disabling symptoms, cardiometabolic comorbidities and reduction in physical activity. Continuous positive airway pressure (CPAP) is the standard treatment for OSA. Only a few studies have characterized trajectories of sleep parameters upon initiation of CPAP and these are limited to one or two nights of polysomnographic recording in a sleep laboratory. This is due to the cost of carrying out these studies and poor tolerance by patients of multiple nights of polysomnographic recordings. No study has characterized sleep over multiple nights before and after CPAP initiation, assessing the multidimensional efficacy of CPAP on patient reported outcomes, objective and subjective sleep quality, oximetry, glucose control and physical activity.
New digital technologies enable overnight sleep studies over several nights in the patient’s home, with a reliability of sleep characterization equivalent to polysomnographic recording.
The primary aim of this study is to investigate objective slow wave sleep (SWS or N3) quality before CPAP and during the first month of the treatment.
Secondary objectives are to assess changes in the following parameters before CPAP and during the first month of the treatment: other objective sleep parameters and sleep stages evolution (W, N1, N2 and REM), nocturnal oxygen desaturations, 24-h blood glucose profile, daily physical activity (the daily steps count), and patient reported outcomes.

Methods
Seventy patients prescribed CPAP for OSA will be recruited at Grenoble Alpes University Hospital (France) and monitored for 5 weeks using validated innovative wearable connected devices (the Dreem 3 headband, a pedometer, an oximeter, and a continuous glucose sensor) enabling them to track their own sleep and physiological parameters at home before and after CPAP initiation.

Discussion
By pooling data from the CPAP telemonitoring and other connected devices we should be able to follow the multidimensional trajectories of patients after the initiation of CPAP. This will enable us to determine whether objective changes in sleep parameters in the first few weeks of CPAP treatment are associated with improvements in daytime sleepiness, quality of life, treatment adherence, glucose control and physical activity. The data will provide integrated markers of treatment efficacy and will allow adapted personalized management of OSA in the short and long-term.

Trial registration
Clinicaltrials (NCT05197855).
Prognostic Implications of Small Cell Lung Cancer Transcriptional Subtyping for CNS Metastases
Authors: Tringale Kathryn R. , Skakodub Anna , Egger Jacklynn , Eichholz Jordan , Yu Yao , Gomez Daniel , Rimner Andreas , Li Bob , Yamada Yoshiya , Wilcox Jessica , Moss Nelson , Imber Brandon S. , Rekhtman Natasha , Baine Marina K. , Rudin Charles M. , Pike Luke R.G. 
Published: May 2024

PURPOSE Small cell lung cancer (SCLC) often metastasizes to the brain and has poor prognosis. SCLC subtypes distinguished by expressing transcriptional factors ASCL1 or NEUROD1 have been identified. This study investigates the impact of transcription factor–defined SCLC subtype on incidence and outcomes of brain metastases (BMs). METHODS Patients with SCLC with ASCL1 (A) and NEUROD1 (N) immunohistochemical expression status were identified and classified: (1) A+/N–, (2) A+/N+, (3) A–/N+, and (4) A–/N–. Cumulative incidence competing risk analyses were used to assess incidence of CNS progression. Cox proportional hazards models were used for multivariable analyses of overall survival (OS) and CNS progression-free survival (CNS-PFS). RESULTS Of 164 patients, most were either A+/N– or A+/N+ (n = 62, n = 63, respectively). BMs were present at diagnosis in 24 patients (15%). Among them, the 12-month cumulative incidence of subsequent CNS progression was numerically highest for A+/N– (50% [95% CI, 10.5 to 74.7]; P = .47). Among those BM-free at diagnosis, the 12-month cumulative incidence of CNS progression was numerically the highest for A+/N– (16% [95% CI, 7.5 to 27.9]) and A–/N+ (9.1% [95% CI, 0.0 to 34.8]; P = .20). Both subtypes, A+/N– and A–/N+, had worse OS compared with A+/N+ (A+/N–: hazard ratio [HR], 1.62 [95% CI, 1.01 to 2.51]; P < .05; A–/N+: HR, 3.02 [95% CI, 1.35 to 6.76]; P = .007). Excellent response rates (28, 65% CR/PR) across subtypes were seen in patients who had CNS-directed radiotherapy versus systemic therapy alone (9, 36% CR/PR). CONCLUSION To our knowledge, this report is the first to investigate CNS-specific outcomes based on transcription factor subtypes in patients with SCLC. BM-free patients at diagnosis with A+/N– or A–/N+ subtypes had worse outcomes compared with those with transcriptional factor coexpression. Further investigation into the mechanisms and implications of SCLC subtyping on CNS-specific outcomes is warranted to ultimately guide personalized care.
Molecular functions of ANKLE2 and its implications in human disease
Authors: Fishburn Adam T. , Florio Cole J. , Lopez Nick J. , Link Nichole L. , Shah Priya S. 
Published: May 2024

ABSTRACTAnkyrin repeat and LEM domain-containing 2 (ANKLE2) is a scaffolding protein with established roles in cell division and development, the dysfunction of which is increasingly implicated in human disease. ANKLE2 regulates nuclear envelope disassembly at the onset of mitosis and its reassembly after chromosome segregation. ANKLE2 dysfunction is associated with abnormal nuclear morphology and cell division. It regulates the nuclear envelope by mediating protein-protein interactions with barrier to autointegration factor (BANF1; also known as BAF) and with the kinase and phosphatase that modulate the phosphorylation state of BAF. In brain development, ANKLE2 is crucial for proper asymmetric division of neural progenitor cells. In humans, pathogenic loss-of-function mutations in ANKLE2 are associated with primary congenital microcephaly, a condition in which the brain is not properly developed at birth. ANKLE2 is also linked to other disease pathologies, including congenital Zika syndrome, cancer and tauopathy. Here, we review the molecular roles of ANKLE2 and the recent literature on human diseases caused by its dysfunction.
Neuromodulatory Contribution to Muscle Force Production after Short-Term Unloading and Active Recovery
Authors: MARTINO GIOVANNI , VALLI GIACOMO , SARTO FABIO , FRANCHI MARTINO V. , NARICI MARCO V. , DE VITO GIUSEPPE 
Published: May 2024

ABSTRACT

Purpose
Prior evidence has shown that neural factors contribute to the loss of muscle force after skeletal muscle disuse. However, little is known about the specific neural mechanisms altered by disuse. Persistent inward current (PIC) is an intrinsic property of motoneurons responsible for prolonging and amplifying the synaptic input, proportionally to the level of neuromodulation, thus influencing motoneuron discharge rate and force production. Here, we hypothesized that short-term unilateral lower limb suspension (ULLS) would reduce the neuromodulatory input associated with PIC, contributing to the reduction of force generation capacity. In addition, we tested whether physical exercise would restore the force generation capacity by reestablishing the initial level of neuromodulatory input.

Methods
In 12 young adults, we assessed maximal voluntary contraction pre- and post-10 d of ULLS and after 21 d of active recovery (AR) based on resistance exercise. PIC was estimated from high-density surface electromyograms of the vastus lateralis muscle as the delta frequency (ΔF) of paired motor units calculated during isometric ramped contractions.

Results
The values of ΔF were reduced after 10 d of ULLS (−33%, P < 0.001), but were fully reestablished after the AR (+29.4%, P < 0.001). The changes in estimated PIC values were correlated (r = 0.63, P = 0.004) with the reduction in maximal voluntary contraction after ULLS (−29%, P = 0.002) and its recovery after the AR (+28.5%, P = 0.003).

Conclusions
Our findings suggest that PIC estimates are reduced by muscle disuse and may contribute to the loss of force production and its recovery with exercise. Overall, this is the first study demonstrating that, in addition to peripheral neuromuscular changes, central neuromodulation is a major contributor to the loss of force generation capacity after disuse, and can be recovered after resistance exercise.
A 30-year follow-up study of rotational acetabular osteotomy for pre- and early-stage osteoarthritis secondary to dysplasia of the hip
Authors: Yasunaga Yuji , Oshima Seigo , Shoji Takeshi , Adachi Nobou , Ochi Mitsuo 
Published: May 2024

AimsThe objective of this study was to present the outcomes of rotational acetabular osteotomy (RAO) over a 30-year period for osteoarthritis (OA) secondary to dysplasia of the hip in pre- or early-stage OA.MethodsBetween September 1987 and December 1994, we provided treatment to 47 patients (55 hips) with RAO for the management of pre- or early-stage OA due to developmental hip dysplasia. Of those, eight patients (11 hips) with pre-OA (follow-up rate 79%) and 27 patients (32 hips) with early-stage OA (follow-up rate 78%), totalling 35 patients (43 hips) (follow-up rate 78%), were available at a minimum of 28 years after surgery.ResultsIn the pre-OA group, the mean Merle d'Aubigné score improved significantly from 14.5 points (SD 0.7) preoperatively to 17.4 points at final follow-up (SD 1.2; p = 0.004) and in the early-stage group, the mean score did not improve significantly from 14.0 (SD 0.3) to 14.6 (SD 2.4; p = 0.280). Radiologically, the centre-edge angle, acetabular roof angle, and head lateralization index were significantly improved postoperatively in both groups. Radiological progression of OA was observed in two patients (two hips) in the pre-OA group and 17 patients (18 hips) in the early-stage group. Kaplan-Meier survival analysis, with radiological progression of OA as the primary outcome, projected a 30-year survival rate of 81.8% (95% confidence interval (CI) 0.59 to 1.00) for the pre-OA group and 42.2% (95% CI 0.244 to 0.600) for the early-stage group. In all cases, the overall survival rate stood at 51.5% (95% CI 0.365 to 0.674) over a 30-year period, and when the endpoint was conversion to total hip arthroplasty, the survival rate was 74.0% (95% CI 0.608 to 0.873).ConclusionFor younger patients with pre-OA, joint preservation of over 30 years can be expected after RAO.Cite this article: Bone Joint J 2024;106-B(5 Supple B):25–31.
Acetabular component liner exchange with highly crosslinked polyethylene for wear and osteolysis
Authors: Liu Wai K. T. , Cheung Amy , Fu Henry , Chan Ping K. , Chiu Kwong Y. 
Published: May 2024

AimsIsolated acetabular liner exchange with a highly crosslinked polyethylene (HXLPE) component is an option to address polyethylene wear and osteolysis following total hip arthroplasty (THA) in the presence of a well-fixed acetabular shell. The liner can be fixed either with the original locking mechanism or by being cemented within the acetabular component. Whether the method used for fixation of the HXLPE liner has any bearing on the long-term outcomes is still unclear.MethodsData were retrieved for all patients who underwent isolated acetabular component liner exchange surgery with a HXLPE component in our institute between August 2000 and January 2015. Patients were classified according to the fixation method used (original locking mechanism (n = 36) or cemented (n = 50)). Survival and revision rates were compared. A total of 86 revisions were performed and the mean duration of follow-up was 13 years.ResultsA total of 20 patients (23.3%) had complications, with dislocation alone being the most common (8.1%; 7/86). Ten patients (11.6%) required re-revision surgery. Cementing the HXLPE liner (8.0%; 4/50) had a higher incidence of re-revision due to acetabular component liner-related complications than using the original locking mechanism (0%; 0/36; p = 0.082). Fixation using the original locking mechanism was associated with re-revision due to acetabular component loosening (8.3%; 3/36), compared to cementing (0%; 0/50; p = 0.038). Overall estimated mean survival was 19.2 years. There was no significant difference in the re-revision rate between the original locking mechanism (11.1%; 4/36) and cementing (12.0%; 6/50; p = 0.899). Using Kaplan-Meier survival analysis, the revision-free survival of HXLPE fixed with the original locking mechanism and cementing was 94.1% and 93.2%, respectively, at ten years, and 84.7% and 81.3%, respectively, at 20 years (p = 0.840).ConclusionThe re-revision rate and the revision-free survival following acetabular component liner exchange revision surgery using the HXLPE liner were not influenced by the fixation technique used. Both techniques were associated with good survival at a mean follow-up of 13 years. Careful patient selection is necessary for isolated acetabular component liner exchange revision surgery in order to achieve the best outcomes.Cite this article: Bone Joint J 2024;106-B(5 Supple B):59–65.
Preliminary Evaluation of Bending Properties in Dimension Lumber of Paulownia tomentosa as a Fast-Growing Tree Species in Japan
Authors: Ishiguri Futoshi , Nezu Ikumi , Nihei Masashi , Kato Shigeru , Otani Naoki , Ohshima Jyunichi , Yokota Shinso 
Published: May 2024

Abstract
The aim of this study is to evaluate the possibility of re-establishment of the Paulownia tomentosa (Thunb.) Steud. forestry and wood industry for sustainable wood production in Japan. Bending properties were preliminarily investigated for dimension lumber (2 by 4, 38 by 89 mm in transverse section) and small-clear specimens of this species. The severe slope of grain in lumber reduced the modulus of rupture (MOR) and disturbed the relationship between the modulus of elasticity (MOE) and MOR. Preliminary studies determined a 5 percent lower tolerance limit with a 75 percent confidence level in MOR of lumber was 12.1 MPa. The value exceeded the characteristic value of MOR of 2 by 4 lumber in structural grade Western redcedar (Thuja plicata).
ASPEK HAK KEKAYAAN INTELEKTUAL DALAM PENGEMBANGAN POTENSI 12 DESTINASI WISATA PESISIR DI JAKARTA UTARA
Authors: Mahatmi Dini 
Published: May 2024

Upaya pengembangan dan penciptaan nilai tambah secara berkelanjutan bagi berbagai potensi kepariwisataan diperlukan perlindungan hukum atas berbagai karya, baik untuk yang telah ada maupun yang akan dihasilkan nantinya. Berkaitan dengan ini Pemerintah Kota Jakarta Utara bermaksud memberikan perlindungan hukum atas kekayaan intelektual sehingga dapat menjaga orisinalitas, serta menghindari pemalsuan atau persaingan usaha yang tidak sehat. Tujuan dari penyusunan tesis ini adalah melakukan audit atas potensi perlindungan hukum bagi berbagai atribut produk yang ada dapat diidentifikasi, berbagai atribut produk yang dipandang perlu untuk mendapatkan perlindungan HKI. Pendekatan penelitian yang digunakan adalah yuridis empiris karena penelitian hukum ini menggunakan data dari bahan-bahan pustaka (data sekunder), dan data yang diperoleh langsung dari masyarakat (data primer). Hasil penelitian ini memberikan kesimpulan bahwa dengan keragaman yang ada, jenis atribut produk yang memerlukan perlindungan tersebut dapat dibagi dalam 2 kelompok, yaitu : (1) obyek perlindungan yang bersifat umum, dapat diimplementasikan pada 12 Destinasi Wisata, dan (2) obyek perlidungan yang bersifat spesifik berkaitan dengan identitas masing-masing destinasi. Hal yang memerlukan perhatian lebih lanjut bila proses perlindungan tersebut dilakukan adalah, bahwa kepemilikan atau penguasaan pelaksanaan pengelolaan atas masing-masing destinasi dilakukan oleh berbagai pihak, baik yang dikuasai atau dikelola oleh badan hukum maupun oleh masyarakat.