Mechanism of Ca2+Transport by Sarcoplasmic Reticulum
Authors: Martonosi Anthony N. , Beeler Troy J. 
Published: November 2010

AbstractThe sections in this article are:Structure of Sarcoplasmic Reticulum and Transverse TubulesStructure of Plasmalemma and T TubulesSarcoplasmic ReticulumJunction Between T Tubules andSRMechanism of Excitation‐Contraction CouplingIsolation ofSR, T Tubules, and Surface Membrane Elements from Skeletal MuscleSeparation of Membrane Fractions by Calcium Oxalate or Calcium Phosphate LoadingProtein Composition ofSRStructure of Ca2+‐TransportATPase and Its Disposition inSRMembraneFragmentation of Ca2+‐ATPase With Proteolytic EnzymesPrimary Sequence of Ca2+‐TransportATPase From RabbitSRStructure of ProteolipidsStructure and Distribution of Calsequestrin and High‐Affinity Ca2+‐Binding Protein inSRLipid Composition ofSRDistribution of Phospholipids in Membrane BilayerRole of Phospholipids in Atpase Activity andCA2+TransportBoundary Lipids and the Problem of Lipid AnnulusRate ofATPHydrolysis and Physical Properties of the Lipid PhaseMobility of Phospholipids and Ca2+‐TransportATPase inSRMechanism ofATPHydrolysis andCA2+TransportIntroduction of Reaction SequenceCa2+Binding toSRBinding of Ca2+to Ca2+‐TransportATPaseBinding of Mg2+to Ca2+‐ATPaseBinding ofATPto Ca2+‐ATPaseBinding of Various Substrates to Ca2+‐ATPaseInfluence ofATPon Mobility and Reactivity of Protein Side‐Chain GroupsFormation of Enzyme‐Substrate ComplexFormation and Properties of PhosphoproteinsKinetics of E∼P FormationRelationship Between Enzyme Phosphorylation and Translocation of CalciumChanges in Ca2+Affinity of Phosphoenzyme During Ca2+TranslocationADP‐Sensitive andADP‐insensitive Phosphoprotein IntermediatesEffect of Potassium onATPaseActivity and Ca2+TransportReversal of theCA2+PumpCa2+Release Induced byADP+PiCa2+Gradient‐Dependent Phosphorylation ofATPaseby PiArsenate‐Induced Ca2+ReleaseMechanism of Ca2+Release Induced byADP+PiCa2+Gradient‐Independent Phosphorylation of Ca2+‐ATPaseby PiRole of Ca2+‐Protein Interactions inATPSynthesisPiHOHExchangeNTPPiExchangePhysical Basis ofCA2+TranslocationProtein‐Protein Interactions inSRand Their Functional SignificanceElectron MicroscopyFluorescence‐Energy TransferElectron Spin Resonance StudiesATPase‐ATPase Interactions in Detergent SolutionsChemical Cross‐LinkingEffects of Inhibitors onATPaseActivityPossibility of Subunit HeterogeneityConclusionPermeability ofSRMonovalent‐Cation Channels inSRAnion Channels inSREffect of Membrane Proteins on Permeability ofSRMembranesRelationship Between Membrane Potential and Calcium Fluxes AcrossSRMembraneProbes as Indicators ofSRMembrane PotentialInfluence ofSRMembrane Potential on Calcium PermeabilityInfluence of Membrane Potential on Active Calcium TransportEffect of Calcium Uptake on Membrane Potential ofSRA Critical Analysis of Experimental Findings on Effects of Ca2+Transport on Membrane PotentialEffect of Calcium on Optical Response of Positive Cyanine DyesResponse of Negatively Charged Dyes to Calcium Transport bySRVesiclesMembrane Potential ofSRIn VivoEffect of Ca2+Release on Membrane Potential ofSRTransport ofCA2+by CardiacSRKinetic Differences BetweenSRof Fast‐Twitch and Slow‐Twitch Skeletal MusclesRegulation ofCA2+Transport by Membrane PhosphorylationRole of Protein Kinase‐Dependent Membrane Phosphorylation in Regulation of Ca2+Transport by Skeletal MuscleSRPhysiological Significance of Phospholamban PhosphorylationBiosynthesis ofSRStudies onSRDevelopment In VivoAssembly ofSRin Cultured Skeletal and Cardiac MuscleSynthesis of Ca2+‐TransportATPasein Cell‐Free Systems and Its Insertion into the MembraneSynthesis of CalsequestrinRegulation of Synthesis of Ca2+‐TransportATPaseMyogenic RegulationNeural Influence on Concentration of Ca2+‐ATPasein Muscle Cells