Safety of the PCSK9 inhibitor alirocumab: insights from 47 296 patient-years of observation
Authors: Goodman Shaun G , Steg Philippe Gabriel , Szarek Michael , Bhatt Deepak L , Bittner Vera A , Diaz Rafael , Harrington Robert A , Jukema J Wouter , White Harvey D , Zeiher Andreas M , Manvelian Garen , Pordy Robert , Poulouin Yann , Stipek Wanda , Garon Genevieve , Schwartz Gregory G ,   ODYSSEY OUTCOMES Investigators, Schwartz Gregory G , Steg Ph Gabriel , Bhatt Deepak L , Bittner Vera A , Diaz Rafael , Goodman Shaun G , Harrington Robert A , Jukema J Wouter , Szarek Michael , White Harvey D , Zeiher Andreas M , Tricoci Pierluigi , Roe Matthew T , Mahaffey Kenneth W , Edelberg Jay M , Hanotin Corinne , Lecorps Guillaume , Moryusef Angèle , Pordy Robert , Sasiela William J , Tamby Jean-François , Diaz Rafael , Aylward Philip E , Drexel Heinz , Sinnaeve Peter , Dilic Mirza , Lopes Renato D , Gotcheva Nina N , Goodman Shaun G , Prieto Juan-Carlos , Yong Huo , López-Jaramillo Patricio , Pećin Ivan , Reiner Zeljko , Ostadal Petr , Poulsen Steen Hvitfeldt , Viigimaa Margus , Nieminen Markku S , Danchin Nicolas , Chumburidze Vakhtang , Marx Nikolaus , Liberopoulos Evangelos , Valdovinos Pablo Carlos Montenegro , Tse Hung-Fat , Kiss Robert Gabor , Xavier Denis , Zahger Doron , Valgimigli Marco , Kimura Takeshi , Kim Hyo Soo , Kim Sang-Hyun , Erglis Andrejs , Laucevicius Aleksandras , Kedev Sasko , Yusoff Khalid , López Gabriel Arturo Ramos , Alings Marco , White Harvey D , Halvorsen Sigrun , Flores Roger M Correa , Sy Rody G , Budaj Andrzej , Morais Joao , Dorobantu Maria , Karpov Yuri , Ristic Arsen D , Chua Terrance , Murin Jan , Fras Zlatko , Dalby Anthony J , Tuñón José , de Silva H Asita , Hagström Emil , Landmesser Ulf , Chiang Chern-En , Sritara Piyamitr , Guneri Sema , Parkhomenko Alexander , Ray Kausik K , Moriarty Patrick M , Chaitman Bernard , Kelsey Sheryl F , Olsson Anders G , Rouleau Jean-Lucien , Simoons Maarten L , Alexander Karen , Meloni Chiara , Rosenson Robert , Sijbrands Eric J G , Tricoci Pierluigi , Alexander John H , Armaganijan Luciana , Bagai Akshay , Bahit Maria Cecilia , Brennan J Matthew , Clifton Shaun , DeVore Adam D , Deloatch Shalonda , Dickey Sheila , Dombrowski Keith , Ducrocq Grégory , Eapen Zubin , Endsley Patricia , Eppinger Arleen , Harrison Robert W , Hess Connie Ng , Hlatky Mark A , Jordan Joseph Dedrick , Knowles Joshua W , Kolls Bradley J , Kong David F , Leonardi Sergio , Lillis Linda , Lopes Renato D , Maron David J , Mahaffey Kenneth W , Marcus Jill , Mathews Robin , Mehta Rajendra H , Mentz Robert J , Patel Chetan B , Pereira Sabrina Bernardez , Perkins Lynn , Povsic Thomas J , Puymirat Etienne , Roe Matthew T , Jones William Schuyler , Shah Bimal R , Sherwood Matthew W , Stringfellow Kenya , Sujjavanich Darin , Toma Mustafa , Trotter Charlene , van Diepen Sean F P , Wilson Matthew D , Yan Andrew Tze-Kay , Schiavi Lilia B , Garrido Marcelo , Alvarisqueta Andrés F , Sassone Sonia A , Bordonava Anselmo P , De Lima Alberto E Alves , Schmidberg Jorge M , Duronto Ernesto A , Caruso Orlando C , Novaretto Leonardo P , Hominal Miguel Angel , Montaña Oscar R , Caccavo Alberto , Vilamajo Oscar A Gomez , Lorenzatti Alberto J , Cartasegna Luis R , Paterlini Gustavo A , Mackinnon Ignacio J , Caime Guillermo D , Amuchastegui Marcos , Salomone Oscar , Codutti Oscar R , Jure Horacio O , Bono Julio O E , Hrabar Adrian D , Vallejos Julio A , Guerrero Rodolfo A Ahuad , Novoa Federico , Patocchi Cristian A , Zaidman Cesar J , Giuliano Maria E , Dran Ricardo D , Vico Marisa L , Carnero Gabriela S , Guzman Pablo N , Allende Juan C Medrano , Brasca Daniela F Garcia , Labarta Miguel H Bustamante , Nani Sebastian , Blumberg Eduardo D S , Colombo Hugo R , Liberman Alberto , Fuentealba Victorino , Luciardi Hector L , Waisman Gabriel D , Berli Mario A , Garcia Duran Ruben O , Cestari Horacio G , Luquez Hugo A , Giordano Jorge A , Saavedra Silvia S , Zapata Gerardo , Costamagna Osvaldo , Llois Susana , Waites Jonathon H , Collins Nicholas , Soward Allan , Aylward Philip E , Hii Chris L S , Aylward Philip E , Shaw James , Arstall Margaret A , Horowitz John , Ninio Daniel , Rogers James F , Colquhoun David , Flores Romulo E Oqueli , Roberts-Thomson Philip , Raffel Owen , Lehman Sam J , Aroney Constantine , Coverdale Steven G M , Garrahy Paul J , Starmer Gregory , Sader Mark , Carroll Patrick A , Dick Ronald , Zweiker Robert , Hoppe Uta , Drexel Heinz , Huber Kurt , Berger Rudolf , Delle-Karth Georg , Frey Bernhard , Faes Dirk , Hermans Kurt , Pirenne Bruno , Leone Attilio , Hoffer Etienne , Sinnaeve Peter , Vrolix Mathias C M , De Wolf Luc , Wollaert Bart , Castadot Marc , Dujardin Karl , Beauloye Christophe , Vervoort Geert , Striekwold Harry , Convens Carl , Roosen John , Barbato Emanuele , Claeys Marc , Cools Frank , Terzic Ibrahim , Barakovic Fahir , Midzic Zlatko , Pojskic Belma , Fazlibegovic Emir , Dilic Mirza , Durak-Nalbantic Azra , Kulić Mehmed , Vulic Dusko , Muslibegovic Adis , Goronja Boris , Reis Gilmar , Sousa Luciano , Nicolau Jose C , Giorgeto Flavio E , Silva Ricardo P , Maia Lilia Nigro , Rech Rafael , Rossi Paulo R F , Cerqueira Maria José A G , Duda Norberto , Kalil Renato , Kormann Adrian , Abrantes José Antonio M , Filho Pedro Pimentel , Soggia Ana Priscila , de Santos Mayler O N , Neuenschwander Fernando , Bodanese Luiz C , Michalaros Yorghos L , Eliaschewitz Freddy G , Vidotti Maria H , Leaes Paulo E , Botelho Roberto V , Kaiser Sergio , Manenti Euler Roberto F Fernandes , Precoma Dalton B , Jorge Jose C Moura , Silva Pedro , Silveira Jose A , Saporito Wladmir , Neto Jose A Marin , Feitosa Gilson S , Ritt Luiz Eduardo F , de Souza Juliana A , Costa Fernando , Souza Weimar K S B , Reis Helder J L , Lopes Renato D , Machado Leandro , Ayoub José Carlos Aidar , Todorov Georgi V , Nikolov Fedya P , Velcheva Elena S , Tzekova Maria L , Benov Haralambi O , Petranov Stanislav L , Tumbev Haralin S , Shehova-Yankova Nina S , Markov Dimitar T , Raev Dimitar H , Mollov Mihail N , Kichukov Kostadin N , Ilieva-Pandeva Katya A , Gotcheva Nina N , Ivanova Raya , Gospodinov Maryana , Mincheva Valentina M , Lazov Petar V , Dimov Bojidar I , Senaratne Manohara , Stone James , Kornder Jan , Dion Danielle , Savard Daniel , Pesant Yves , Pandey Amritanshu , Robinson Simon , Gosselin Gilbert , Vizel Saul , Hoag Gordon , Bourgeois Ronald , Morisset Anne , Sabbah Eric , Sussex Bruce , Kouz Simon , MacDonald Paul , Diaz Ariel , Michaud Nicolas , Fell David , Vuurmans Tycho , Lai Christopher , Nigro Frank , Davies Richard , Nogareda Gustavo , Vijayaraghavan Ram , Ducas John , Lepage Serge , Mehta Shamir , Cha James , Dupuis Robert , Fong Peter , Lutchmedial Sohrab , Rodes-Cabau Josep , Fadlallah Hussein , Cleveland David , Huynh Thao , Bata Iqbal , Hameed Adnan , Pincetti Cristian , Potthoff Sergio , Prieto Juan C , Acevedo Monica , Aguirre Arnoldo , Vejar Margarita , Yañez Mario , Araneda Guillermo , Fernandez Mauricio , Perez Luis , Varleta Paola , Florenzano Fernando , Huidobro Laura , Raffo Carlos A , Olivares Claudia , Nahuelpan Leonardo , Montecinos Humberto , Chen Jiyan , Dong Yugang , Huang Weijian , Wang Jianzhong , Huang Shi'An , Yao Zhuhua , Li Xiang , Cui Lan , Lin Wenhua , Sun Yuemin , Wang Jingfeng , Li Jianping , Zhang Xuelian , Zhu Hong , Chen Dandan , Huang Lan , Dong Shaohong , Su Guohai , Xu Biao , Su Xi , Cheng Xiaoshu , Lin Jinxiu , Zong Wenxia , Li Huanming , Feng Yi , Xu Dingli , Yang Xinchun , Ke Yuannan , Lin Xuefeng , Zhang Zheng , Zheng Zeqi , Luo Zhurong , Chen Yundai , Ding Chunhua , Zhong Yi , Zheng Yang , Li Xiaodong , Peng Daoquan , Zhao Shuiping , Li Ying , Liu Xuebo , Wei Meng , Liu Shaowen , Yu Yihua , Qu Baiming , Jiang Weihong , Zhou Yujie , Zhao Xingsheng , Yuan Zuyi , Guo Ying , Xu Xiping , Shi Xubo , Ge Junbo , Fu Guosheng , Bai Feng , Fang Weiyi , Shou Xiling , Yang Xiangjun , Wang Jian'An , Xiang Meixiang , Sun Yingxian , Lu Qinghua , Zhang Ruiyan , Zhu Jianhua , Xu Yizhou , Fan Zhongcai , Li Tianchang , Wu Chun , Jaramillo Nicolas , Vallejo Gregorio Sanchez , Luna Botia Diana C , Lopez Rodrigo Botero , Molina De Salazar Dora I , Cadena Bonfanti Alberto J , Aroca Carlos Cotes , Higuera Juan Diego , Blanquicett Marco , Barrera Silva Sandra I , Lozada Henry J Garcia , Coronel Arroyo Julian A , Accini Mendoza Jose L , Ruiz Ricardo L Fernandez , Quintero Ossa Alvaro M , Manzur Jatin Fernando G , Herazo Aristides Sotomayor , Parada Jeffrey Castellanos , Arambula Rafael Suarez , Triana Miguel A Urina , Fernandez Trujillo Angela M , Strozzi Maja , Car Siniša , Jerić Melita , Benčić Martina Lovrić , Pintarić Hrvoje , Prvulović Đeiti , Šikić Jozica , Peršić Viktor , Mileta Dean , Štambuk Kresimir , Babić Zdravko , Tomulic Vjekoslav , Lukenda Josip , Mejic-Krstulovic Stanka , Starcevic Boris , Spinar Jindrich , Horak David , Velicka Zdenek , Stasek Josef , Alan David , Machova Vilma , Linhart Ales , Novotny Vojtech , Kaucak Vladimir , Rokyta Richard , Naplava Robert , Coufal Zdenek , Adamkova Vera , Podpera Ivo , Zizka Jiri , Motovska Zuzana , Marusincova Ivana , Svab Premysl , Ostadal Petr , Heinc Petr , Kuchar Jiri , Povolny Petr , Matuska Jiri , Poulsen Steen H , Raungaard Bent , Clemmensen Peter , Bang Lia E , May Ole , Bøttcher Morten , Hove Jens D , Frost Lars , Gislason Gunnar , Larsen John , Johansen Peter Betton , Hald Flemming , Johansen Peter , Jeppesen Jørgen , Nielsen Tonny , Kristensen Kjeld S , Walichiewicz Piotr Maria , Lomholdt Jens D , Klausen Ib C , Nielsen Peter Kaiser , Davidsen Flemming , Videbaek Lars , Viigimaa Margus , Soots Mai , Vahula Veiko , Hedman Anu , Soopõld Üllar , Märtsin Kaja , Jurgenson Tiina , Kristjan Arved , Nieminen Markku S , Huikuri Heikki , Coste Pierre , Ferrari Emile , Danchin Nicolas , Morel Olivier , Montalescot Gilles , Machecourt Jacques , Barone-Rochette Gilles , Mansourati Jacques , Cottin Yves , Steg Ph Gabriel , Leclercq Florence , Belhassane Abdelkader , Delarche Nicolas , Boccara Franck , Paganelli Franck , Clerc Jérôme , Schiele Francois , Aboyans Victor , Probst Vincent , Berland 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Uwe , Killat Holger , Rieker Werner , Patsilinakos Sotiris , Kartalis Athanasios , Manolis Athanassios , Sionis Dimitrios , Chachalis Geargios , Liberopoulos Evangelos , Skoumas Ioannis , Athyros Vasilios , Vardas Panagiotis , Parthenakis Frangkiskos , Alexopoulos Dimitrios , Hahalis Georgios , Lekakis John , Hatzitolios Apostolos , Ovando Sergio R Fausto , Valdovinos Pablo Carlos Montenegro , Arango Benecke Juan L , Rodriguez De Leon Edgar R , Yan Bryan P Y , Siu David C W , Turi Tibor , Merkely Bela , Kiss Robert Gabor , Ungi Imre , Lupkovics Geza , Nagy Lajos , Katona András , Édes István , Müller Gábor , Horvath Iván , Kapin Tibor , Szigeti Zsolt , Faluközy József , Kumbla Mukund , Sandhu Manjinder , Annam Sharath , Proddutur Naveen Reddy , Regella Reddy , Premchand Rajendra K , Mahajan Ajaykumar , Pawar Sudhir , Abhyanakar Atul D , Kerkar Prafulla , Govinda Ravishankar A , Oomman Abraham , Sinha Dhurjati , Patil Sachin N , Kahali Dhiman , Sawhney Jitendra , Joshi Abhijeet B , Chaudhary Sanjeev , Harkut Pankaj , Guha Santanu , Porwal Sanjay , Jujjuru Srimannarayana , Pothineni Ramesh B , Monteiro Minguel R , Khan Aziz , Iyengar Shamanna S , Grewal Jasprakash Singh , Chopda Manoj , Fulwani Mahesh C , Patange Dr Aparna , Sachin Patil , Chopra Vijay K , Goyal Naresh K , Shinde Rituparna , Manakshe Gajendra V , Patki Nitin , Sethi Sumeet , Munusamy Vengatesh , Thanvi Sunil Karnaand Sunil , Adhyapak Srilakshmi , Patil Chandrakant , Pandurangi Ulhas , Mathur Rishabh , Gupta Jugal , Kalashetti Suhas , Bhagwat Ajit , Raghuraman Bagirath , Yerra Shiv Kumar , Bhansali Prasant , Borse Rohidas , Rahul Patil , Das Srihari , Kumar Vinay , Abdullakutty Jabir , Saathe Shireesh , Palimkar Priya , Abdullkutty Jabir , Sathe Shireesh , Atar Shaul , Shechter Michael , Mosseri Morris , Arbel Yaron , Ehud Chorin , Ofer Havakuk , Lotan Chaim , Rosenschein Uri , Katz Amos , Henkin Yaakov , Francis Adi , Klutstein Marc , Nikolsky Eugenia , Zukermann Robert , Turgeman Yoav , Halabi 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Borger-Van Der Burg Alida , Hoogslag Pieter A M , Suryapranata Harry , Oomen Antonius , Van Haelst Paulus , Feenema-Aradema Margriet , Wiersma Jacobijne J , Basart Dirk , Van Der Wal Ruud M A , Zwart Peter , Monraats Pascalle , Van Kesteren Henricus , Karalis Ioannis , Jukema Johan , Verdel Gerardus J E , Brueren Bart R G , Troquay Roland P T h , Viergever Eric P , Al-Windy Nadea Y Y , Bartels Gerard L , Cornel Jan H , Hermans Walter R M , Herrman Johannes P R , Bos Robert J , Groutars Reginald G E J , Van Der Zwaan Coenraad C , Kaplan Refik , Lionarons Raymond , Ronner Eelko , Groenemeijer Bjorn E , Bronzwaer Patrick N A , Liem Anho A H , Rensing Bernard J W M , Bokern Marcel J J A , Nijmeijer Remco , Hersbach Ferry M R J , Willems Frank F , Gosselink Antonius T M , Rasoul Saman , Elliott John , Wilkins Gerard , Fisher Raewyn , Scott Douglas , Hart Hamish , Stewart Ralph , Harding Scott , Ternouth Ian , Fisher Nicholas , Wilson Samuel , Aitken Denise , Anscombe Russell , Davidson Laura , Tomala Tadeusz , Nygård Ottar , Sparby Jon Arne , Andersen Kjell , Gullestad Lars , Jortveit Jarle , Munk Peter S , Singsaas Erlend gyllensten , Halvorsen Sigrun , Hurtig Ulf , Correa Flores Roger M , Calderon Ticona Jorge R , Velasquez Julio R Durand , Miguel Sandra A Negron , Perez Enrique S Sanabria , Carrion Chambilla Jesus M , Chavez Ayala Carlos A , Leon Reynaldo P Castillo , Vargas Gonzales Rolando J , Hernandez Zuniga Jose D , Cosavalente Luis A Camacho , Bravo Mannucci Jorge E , Landeo Javier Heredia , Llerena Navarro Nassip C , Concha Yudy M Roldan , Rodriguez Chavez Víctor E , Anchante Hernandez Henry A , Zea Nunez Carlos A , Ramos Walter Mogrovejo , Ferrolino Arthur , Sy Rosa Allyn G , Tirador Louie , Sy Rody G , Matiga Generoso , Coching Raul Martin , Bernan Alisa , Rogelio Gregorio , Morales Dante D , Tan Edgar , Sulit Dennis Jose , Wlodarczak Adrian , Jaworska Krystyna , Skonieczny Grzegorz , Pawlowicz Lidia , Wojewoda Pawel , Busz-Papiez Benita , Bednarski Janusz , Goch Aleksander , Staneta Pawel , Dulak Elzbieta , Budaj Andrzej , Saminski Krzysztof , Krasowski Wlodzimierz , Sudnik Wanda , Zurakowski Aleksander , Skorski Marcin , Lysek Roman , Miklaszewicz Beata , Kubica Jacek , Lipko Jan Andrzej , Kostarska-Srokosz Edyta , Piepiorka Marek , Drzewiecka Anna , Sciborski Ryszard , Stasiewski Arkadiusz , Blicharski Tomasz , Bystryk Leszek , Szpajer Michal , Korol Marek , Czerski Tomasz , Mirek-Bryniarska Ewa , Gniot Jacek , Lubinski Andrzej , Gorny Jerzy , Franek Edward , Raczak Grzegorz , Szwed Hanna , Monteiro Pedro , Bastos Jose Mesquita , Pereira Helder H , Martins Dinis , Morais Joao , Seixo Filipe , Mendonça Carlos , Botelho Ana , Caetano Francisca , Minescu Bogdan , Istratoaie Octavian , Tesloianu Dan N , Dorobantu Maria , Cristian Gabriel , Dumitrescu Silviu , Podoleanu Cristian G C , Constantinescu Mircea C A , Bengus Cristina M , Militaru Constantin , Rosu Doina , Parepa Irinel R , Matei Adrian V , Alexandru Tom M , Malis Mihaela , Coman Ioan , Stanescu-Cioranu Rodica , Dimulescu Doina , Shvarts Yury , Orlikova Olga , Kobalava Zhanna , Barbarash Olga L , Markov Valentin , Lyamina Nadezhda , Gordienko Alexander , Zrazhevsky Konstantin , Vishnevsky Alexander Y , Gurevich Victor , Stryuk Raisa , Lomakin Nikita V , Bokarev Igor , Khlevchuk Tatiana , Shalaev Sergey , Khaisheva Larisa , Chizhov Petr , Viktorova Inna , Osokina Natalya , Shchekotov Vladimir , Akatova Evgenia , Chumakova Galina , Libov Igor , Voevoda Mikhail I , Tretyakova Tatyana V , Baranov Evgeny , Shustov Sergey , Yakushin Sergey , Gordeev Ivan , Khasanov Niiaz , Reshetko Olga , Sotnikova Tatiana , Molchanova Olga , Nikolaev Konstantin , Gapon Liudmila , Baranova Elena , Shogenov Zaur , Kosmachova Elena , Karpov Yuriy , Karpov Yuri , Povzun Anton , Egorova Liudmila , Tyrenko Vadim V , Ivanov Igor G , Ilya Masterov , Kanorsky Sergey , Simic Dragan , Ivanovic Nikola , Davidovic Goran , Tasic Nebojsa , Asanin Milika R , Stojic Stevo , Apostolovic 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Commerford Patrick J , Cassimjee Soraya , Riaz Garda , Ebrahim Iftikhar O , Sarvan Mahomed , Mynhardt Joseph H , Dalby Anthony J , Reuter Helmuth , Moodley Rajendran , Vida Manuel , Cequier Fillat Angel R , Peris Vicente Bodí , Jimenez Francisco Fuentes , Marín Francisco , Fernández Jose M Cruz , Urbano Rafael Jesus Hidalgo , Gil-Extremera Blas , Toledo Pablo , Diz Fernando Worner , Garcia-Dorado David , Iñiguez Andres , Fernández José Tuñón , Gonzalez-Juanatey Jose R , Portales Javier Fernandez , Murillo Fernando Civeira , Pericas Laia Matas , Zamorano Jose Luis , Martin Manuel De Mora , Cortada Jordi Bruguera , Alonso Martin Joaquin J , Antolin Jose Maria Serrano , De Berrazueta Fernández José R , de Prada José Antonio Vázquez , Fernández Jose Francisco Díaz , Lledó José Alberto García , Sales Juan Cosín , Rodriguez Javier Botas , Tragant Gabriel Gusi , Benedicto Amparo , Gonzalez-Juanatey Carlos , Potau Mercedes Camprubí , Perez Ignacio Plaza , De La Tassa César Morís , Rincon Pablo Loma-Osorio , Recena Javier Balaguer , Escudier Juan M , Payeras Antonio Coca , Orcajo Norberto Alonso , Valdivielso Pedro , Constantine Godwin , Haniffa Ruvaiz , Tissera Nirmali , Amarasekera Stanley , Ponnamperuma Chandrike , Fernando Nimali , Fernando Kaputella , Jayawardena Jayanthimala , Wijeyasingam Santharaj , Ranasinghe Gotabhaya , Ekanayaka Ruvan , Mendis Sepalika , Senaratne Vajira , Mayurathan Gnanamoorthy , Rajapaksha Ajantha , Sirisena Thilak , Herath Jagath I , Amarasena Naomali , Berglund Stefan , Rasmanis Gundars , Hagström Emil , Vedin Ola , Witt Nils , Mourtzinis Georgios , Nicol Peter , Hansen Ole , Romeo Stefano , Jensen Steen Agergaard , Torstensson Ingemar , Ahremark Ulf , Sundelin Torbjörn , Moccetti Tiziano , Müller Christian , Mach Francois , Binde Ronald , Landmesser Ulf , Gämperli Oliver , Chiang Chern-En , Tsai Wei-Chuan , Ueng Kwo-Chang , Lai Wen-Ter , Liu Ming-En , Hwang Juey-Jen , Yin Wei-Hsian , Hsieh I-Chang , Hsieh Ming-Jer , Lin Wei Hsiang , Kuo Jen-Yuan , Huang Tsuei-Yuan , Fang Chih-Yuan , Kaewsuwanna Pinij , Soonfuang Wasant , Jintapakorn Woravut , Sukonthasarn Apichard , Sritara Piyamitr , Wongpraparut Nattawut , Sastravaha Krisada , Sansanayudh Nakarin , Kehasukcharoen Wirash , Piyayotai Dilok , Chotnoparatpat Paiboon , Camsari Ahmet , Kultursay Hakan , Guneri Sema , Mutlu Bulent , Ersanli Murat , Demirtas Mustafa , Kirma Cevat , Ural Ertan , Koldas Lale , Karpenko Oleksandr , Prokhorov Alexander , Vakaluyk Ihor , Myshanych Halyna , Reshotko Dmytro , Batushkin Valeriy , Rudenko Leonid , Kovalskyi Ihor , Kushnir Mykola , Tseluyko Vira , Mostovoy Yuriy , Stanislavchuk Mykola , Kyiak Yulian , Karpenko Yuriy , Malynovsky Yaroslav , Klantsa Andriy , Kutniy Oles , Amosova Ekaterina , Tashchuk Viktor , Leshchuk Oleh , Parkhomenko Alexander , Rishko Mykola , Kopytsya Mykola , Yagensky Andriy , Vatutin Mykola , Bagriy Andriy , Barna Olga M , Ushakov Olexiy , Dzyak Georgiy , Goloborodko Borys , Rudenko Anatolii , Zheleznyy Volodymyr , Trevelyan Jasper , Zaman Azfar , Lee Kaeng , Moriarty Andrew , Aggarwal Rajesh K , Clifford Piers , Wong Yuk-Ki , Iqbal Syed M R , Subkovas Eduardas , Braganza Denise , Sarkar David , Storey Robert , Griffiths Huw , Mcclure Sam , Muthusamy Rangasamy , Smith Simon , Kurian John , Levy Terry , Barr Craig , Kadr Honer , Gerber Robert , Simaitis Audrius , Soran Handrean , Mathur Anthony , Brodison Adrian , Ayaz Mohammad , Cheema Muhammad , Oliver Richard , Thackray Simon , Mudawi Telal , Rahman Gohar , Sultan Ayyaz , Reynolds Timothy , Sharman David , Sprigings david , Butler Rob , Wilkinson Peter , Lip Gregory Y H , Halcox Julian , Gallagher Sean , Ossei-Gerning Nicholas , Vardi Gil , Baldari Duccio , Brabham David , Treasure Charles , Dahl Charles , Palmer Bruce , Wiseman Alan , Khan Abul , Puri Sanjeev , Mohart Ann Elizabeth , Ince Carlos , Flores Enrique , Wright Scott , Cheng Shi-Chi , Rosenberg Michael , Rogers William , Kosinski Edward , Forgosh Les , Waltman Jonathan , Khan Misal , Shoukfeh Mohammad , Dagher Georges , Cambier Patrick , Lieber Ira , Kumar Priya , East Cara , Krichmar Perry , Hasan Mian , White Lindsey , Knickelbine Thomas , Haldis Thomas , Gillespie Eve , Amidon Thomas , Suh David , Arif Imran , Abdallah mouhamad , Akhter Faiq , Carlson Eric , D'Urso Michael , El-Ahdab Fadi , Nelson William , Moriarty Katie , Harris Barry , Cohen Steven , Carter Luther , Doty Daniel , Sabatino Kenneth , Haddad Tariq , Malik Amir , Rao Sunder , Mulkay Angel , Jovin Ion , Klancke Kim , Malhotra Vinay , Devarapalli Sai K , Koren Michael , Chandna Harish , Dodds George , Goraya Tauqir , Bengston James , Janik Matthew , Moran Joseph , Sumner Andrew , Kobayashi John , Davis William , Yazdani Shahram , Pasquini John , Thakkar Maitreya , Vedere Amarnath , Leimbach Wayne , Rider James , fenton Sarah , Singh Narendra , Shah Anil V , Moriarty Patrick M , Janosik Denise , Pepine Carl , Berman Brett , Gelormini Joseph , Daniels Christopher , Richard Kerensky , Keating Friederike , Kondo Nicholas I , Shetty Sanjay , Levite Howard , Waider Winfried , Takata Theodore , Abu-Fadel Mazen , Shah Vipul , Aggarwal Rahul , Izzo Mark , Kumar Anil , Hattler Brack , Do Rose , Link Chad , Bortnick Anna , Kinzfogl George , Ghitis Arnold , Larry John , Teufel Edward , Kuhlman Peter , Mclaurin Brent , Zhang Wenwu , Thew Stephen , Abbas Jalal , White Matthew , Islam Othman , Subherwal Sumeet , Ranadive Nandkishore , Vakili Babak , Gring Christian , Henderson David , Schuchard Timothy , Farhat Naim , Kline Geoffrey , Mahal Sharan , Whitaker Jack , Speirs Shawn , Andersen Rolf , Daboul Nizar , Horwitz Phillip , Zahr Firas , Ponce George , Jafar Zubair , Mcgarvey Joseph , Panchal Vipul , Voyce Stephen , Blok Thomas , Sheldon William , Azizad Masoud M , Schmalfuss Carsten , Picone Mark , Pederson Robert , Herzog William , Friedman Keith , Lindsey Jason , Nowins Rosemary , Timothy Eichenlaub , Leonard Parilak , Lepor Norman , El Shahawy Mahfouz , Weintraub Howard , Irimpen Anand , Alonso Alvaro , May Wade , Christopher Daniels , Galski Thomas , Chu Alan , Mody Freny , Ramin Ebrahimi , Hodes Zachary , Rossi Joseph , Rose Gregory , Fairlamb James , Lambert Charles , Raisinghani Ajit , Abbate Antonio , Vetrovec George , King Marilyn , Carey Charles , Gerber Jaime , Younis Liwa , Park Hyeun (Tom) , Vidovich Mladen , Knutson Thomas , Friedman Dennis , Chaleff Fred , Loussararian Arthur , Rozeman Phillip , Kimmelstiel Carey , Kuvin Jeffrey , Silver Kevin , Foster Malcolm , Tonnessen Glen , Espinoza Andrey , Amlani Mohamadali , Wali Andreas , Malozzi Christopher , Jong Geert T , Massey Clara , Wattanakit Keattiyoat , O'Donnell Philip J , Singal Dinesh , Jaffrani Naseem , Banuru Sridhar , Fisher Daniel , Xenakis Mark , Perlmutter Neal , Bhagwat Ravi , Strader James , Blonder Ronald , Akyea-Djamson Ayim , Labroo Ajay , Lee Kwan , Marais H John , Claxton Edmund , Weiss Robert , Kathryn Rohr , Berk Martin , Rossi Peter , Joshi Parag , Khera Amit , Khaira Ajit S , Kumkumian Greg , Lupovitch Steven , Purow Joshua , Welka Stephen , Hoffman David , Fischer Stuart , Soroka Eugene , Eagerton Donald , Pancholy Samir , Ray Michael , Erenrich Norman , Farrar Michael , Pollock Stewart , French William J , Diamantis Steve , Guy Douglas , Gimple Lawrence , Neustel Mark , Schwartz Steven , Pereira Edward , Albert Seals , Spriggs Douglas , Strain Janet , Mittal Suneet , Vo Anthony , Chane Majed , Hall Jason , Vijay Nampalli , Lotun Kapildeo , Lester F Martin , Nahhas Ahed , Pope Theodore , Nager Paul , Vohra Rakesh , Sharma Mukesh , Bashir Riyaz , Ahmed Hinan , Berlowitz Michael , Fishberg Robert , Barrucco Robert , Yang Eric , Radin Michael , Sporn Daniel , Stapleton Dwight , Eisenberg Steven , Landzberg Joel , Mcgough Martin , Turk Samir , Schwartz Michael , Sundram P Sandy , Jain Diwakar , Zainea Mark , Bayron Carlos , Karlsberg Ronald , Dohad Suhail , Lui Henry , Keen William , Westerhausen Donald , Khurana Sandeep , Agarwal Himanshu , Birchem Jessica , Penny William , Chang Mark , Murphy Sherrill , Henry John , Schifferdecker Branislav , Gilbert John M , Chalavarya Gopal , Eaton Charles , Schmedtje John F , Christenson Stuart , Dotani Imran , Denham Douglas , Macdonell Alexander , Gibson Paul , Rahman Aref , Joundi Tammam Al , Assi Nizar , Conrad Gary , Kotha Purushotham , Love Michael , Giesler Gregory , Rubenstein Howard , Gamil Dawood , Akright Laura , Krawczyk Justine , Cobler Joanne , Wells Terry , Welker James , Foster Robert , Gilmore Richard , Anderson Jay , Jacoby Douglas , Harris Bill , Gardner Geraldine , Dandillaya Ramprasad , Vora Kishor , Kostis John , Hunter John , Laxson David , Ball Eric , Anderson Jay , Wells Terry , Vora Kishor , Ball Eric , Welker James , Lopes Renato D , Egydio Flavia , Kawakami Anelise , Oliveira Janaina , Goodman Shaun G , Wozniak Julianna , Matthews Alexander , Ratky Caroline , Valiris Janine , Berdan Lisa , Hepditch Anita , Quintero Kirby , Roe Matthew T , Rorick Tyrus , Westbrook Melissa , Diaz Rafael , Pascual Andrea , Rovito Carla , Danchin Nicolas , Bezault Madeleine , Drouet Elodie , Simon Tabassome , White Harvey D , Alsweiler Caroline , Sinnaeve Peter , Luyten Anne , Aylward Philip E , Butters Julie , Griffith Liddy , Shaw Michelle , Hagström Emil , Grunberg Lena , Szarek Michael , Islam Shahidul , Brégeault Marie-France , Bougon Nathalie , Faustino Douglas , Fontecave Sylvie , Murphy Judith , Tamby Jean-Francois , Verrier Melanie , Agnetti Veronique , Andersen Dorthe , Badreddine Emmy , Bekkouche Mhamed , Bouancheau Cecile , Brigui Imane , Brocklehurst Maddy , Cianciarulo Joseph , Devaul Dawn , Domokos Szilvia , Gache Cecile , Gobillot Caroline , Guillou Severine , Healy Jan , Heath Megan , Jaiwal Gayatri , Javierre Carine , Labeirie Julien , Monier Myriam , Morales Ulises , Mrabti Asmaa , Mthombeni Bicky , Okan Betim , Smith Lucile , Sheller Jennifer , Sopena Sebastien , Pellan Valerie , Benbernou Fadela , Bengrait Nafissa , Lamoureux Maud , Kralova Katarina , Scemama Michel , Bejuit Raphael , Coulange Anthony , Berthou Christelle , Repincay Jérôme , Lorenzato Christelle , Etienne Alexis , Gouet Valerie , Lecorps Guillaume , Loizeau Virginie , Normand Mickael , Ourliac Anne , Rondel Christelle , Adamo Antony , Beltran Pascale , Barraud Pauline , Dubois-Gache Helene , Halle Benjamin , Metwally Lamia , Mourgues Maxime , Sotty Marc , Vincendet Marion , Cotruta Raluca , Chengyue Zhu , Fournie-Lloret Dominique , Morrello Christine , Perthuis Aurelie , Picault Patrick , Zobouyan Isabelle , Colhoun Helen M , Dempsey Michael A , McClanahan Mark A 
Published: April 2024

Abstract
The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety profile of alirocumab was indistinguishable from matching placebo except for a ∼1.7% absolute increase in local injection site reactions. Further, the safety of alirocumab compared with placebo was evident in vulnerable groups identified before randomization, such as the elderly and those with diabetes mellitus, previous ischaemic stroke, or chronic kidney disease. The frequency of adverse events and laboratory-based abnormalities was generally similar to that in placebo-treated patients. Thus, alirocumab appears to be a safe and effective lipid-modifying treatment over a duration of at least 5 years.