bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract 15410: ACE Gene Dosage Influences the Magnitude of Blood Pressure Increase After Chronic High Fructose Intake: Role of Resistance Arteries
Authors: Moraes-Silva Ivana C , de Souza Leandro E , Irigoyen Maria Claudia , Casarini Dulce E 
Published: April 2024

We investigated the mechanisms involved in blood pressure (BP) increase induced by chronic high fructose (F) intake and its association with angiotensin converting enzyme (ACE) dosage.
Male mice harbouring 1, 2 or 3 copies of the ACE gene received F (100g/l) or tap water (C) for 8 weeks. Glucose tolerance and BP were evaluated. BP variability was analyzed in frequency domain. Mesenteric resistance artery reactivity to noradrenaline (Nor; 0.1nM - 1μM), and acetylcholine (Ach; 1nM - 10μM, after or not L-NAME incubation, 100 μM) were studied in an isometric myograph (DMT, 620M).

Glucose intolerance was seen in all F groups vs. C (1 copy: 100+3 vs. F=198+5; 2 copies: 121+4 vs. F=201+8; 3 copies: 86+4 vs. F=212+5 mg/dl at the 120thmin after 1.5 g/Kg ip glucose overload). Systolic BP increased in all F-fed mice (mean C=112+2; F:1 copy=119+3, 2 copies=123+2, 3 copies=129+2 mmHg), with a significant augment in 3-copy group vs. 1 and 2-copy mice. Not only BP variability (1 copy: 39+3 vs. F=57+2; 2 copies: 38+2 vs. F=59+3; 3 copies: 40+3 vs. F=73+7 mmHg
2
) but also its sympathetic component (LF; 1 copy: 5+1 vs. F=12+3; 2 copies: 6+2 vs. F=19+3; 3 copies: 7+2 vs. F=31+5 %) increased in all F groups, with a more pronounced augment in 3-copy mice vs. 1 and 2. Moreover, F-fed 3-copy mice reactivity to Nor was superior than the other groups (1 copy: 170+5; 2 copies: 190+7; 3 copies: 214+10 %) while Ach-induced relaxation was more reduced in 3-copy mice than 1 and 2 (mean C: 76+5%; F: 1 copy=58+8, 2 copies=47+6, 3 copies=36+5 %). L-NAME in F-fed groups significantly blocked ~95% of Ach relaxation in 3-copy mice vs. 75 and 82% in 1 and 2-copy mice, respectively. Additionally, BP variability was negatively correlated to Ach maximal relaxation (r
2
=0.75) and positively correlated to Nor maximal constriction (r
2
=0.78) while glucose levels in the tolerance test were also negatively correlated to Ach maximal relaxation (r
2
=0.72) and positively correlated to Nor maximal constriction (r
2
=0.9).

In conclusion, F-induced BP increase is influenced by ACE levels in mice. Increased BP variability and glucose intolerance are highly associated with microvascular dysfunction.
Abstract 8864: Left Bundle Branch Area Pacing is Non-Inferior to His Bundle Pacing in Achieving Physiologic Repolarization and T-Wave Memory Resolution
Authors: Gupta Anshul , Pavri Behzad B 
Published: April 2024

Introduction:
We have previously reported that His bundle pacing (HBP) results in more physiologic ventricular repolarization as compared to conventional biventricular pacing. Left bundle branch area pacing (LBAP) is increasingly used as the preferred modality of physiologic pacing due to ease of implantation and low long-term pacing thresholds. LBAP and HBP are comparable in terms of achieving physiologic left ventricular (LV) depolarization. However, their effects on ventricular repolarization have not been assessed. Established ECG markers of arrhythmic risk can be used to compare ventricular repolarization across these two modalities of physiologic pacing.

Hypothesis:
LBAP is not inferior to HBP in its effects on ventricular repolarization and T-wave memory resolution.

Methods:
The following parameters were analyzed in patients with HBP (n = 34) and LBAP (n = 16) from post-implant ECGs:

1) QTc: QT corrected using Bazett’s formula in lead V5, and if not measurable, in V4 or V6
2) QTc Dispersion: Longest minus shortest QTc from precordial leads
3) Tp-Te Transmural: T-peak minus T-end in same lead as 1)
4) Tp-Te Total: Earliest T-peak minus latest T-end from all precordial leads
5) Tp Dispersion: Latest minus earliest T-peak from precordial leads
To analyze T-wave memory resolution, QRS-T angles were compared using ECGs within 10 days of and after ≥ 25 days post implant.

Results:
See tables. Median time from implant to 1st ECG for both groups was ≤1 day. None of the repolarization parameters were significantly different in HBP vs. LBAP groups.

Conclusion:
All repolarization markers of arrhythmic risk were similar in HBP vs. LBAP. Both modalities showed similar effects on T-wave memory resolution. These data suggest that LBAP, in addition to achieving physiologic LV depolarization, is not inferior to HBP in achieving physiologic ventricular repolarization. These observations further support the increasing use of LBAP as the preferred modality for physiologic pacing.
Abstract 9857: Epicardial Hdac3 Promotes Myocardial Growth Through a Novel MicroRNA Pathway
Authors: Jang Jihyun , Li Deqiang 
Published: April 2024

Growth cues from epicardium-derived cells (EPDCs) such as Insulin growth factors (IGFs) and Fibroblast Growth Factors (FGFs) are required for compact myocardial growth, although it is unclear whether/how their expression is regulated by chromatin modifications during this process. To understand the potential function of Histone deacetylase 3 (Hdac3) in the developing epicardium, we conditionally inactivated Hdac3 in the EPDCs. Strikingly, deletion of Hdac3 in the epicardium led to ventricular myocardial wall hypoplasia along with the reduction of EPDCs. To identify disrupted growth signals sending from epicardium to myocardium, we deleted Hdac3 in cultured mouse epicardial cells (MECs) by CRISPR/CAS9 and performed RNA Seq analyses. We found that IGF2 and FGF9 were significantly down regulated in Hdac3 knockout (KO) MECs, which can be rescued by re-expression of intact Hdac3 but not by catalytically dead Hdac3. Importantly, the proliferation of cultured primary embryonic cardiomyocytes was significantly decreased when treated with Hdac3 KO MEC supernatant as compared to those treated with control MEC supernatant, and this proliferation decrease was rescued by supplementation of IGF2 or FGF9. Next, we sought to understand how Hdac3 regulates the expression of IGF2 or FGF9. Interestingly, we found that miR-322/503 was significantly upregulated in Hdac3 KO MECs and Hdac3 epicardial KO hearts. Overexpression of miR-322/503 repressed the expression of IGF2 and FGF9, while knockdown of miR-322/503 restored the expression of IGF2 and FGF9 in
Hdac3 KO MECs. Altogether, our findings suggest that Hdac3 in the developing epicardium promotes compact myocardial growth by stimulating IGF2 expression through repressing miR-322/503. Our findings shed light on the potential novel mechanisms of congenital heart defects, and new strategies for myocardial regeneration.
Intrinsic functional connectivity among memory networks does not predict individual differences in narrative recall
Authors: Kurkela Kyle , Ritchey Maureen 
Published: April 2024

Abstract
Individuals differ greatly in their ability to remember the details of past events, yet little is known about the brain processes that explain such individual differences in a healthy young population. Previous research suggests that episodic memory relies on functional communication among ventral regions of the default mode network (“DMN-C”) that are strongly interconnected with the medial temporal lobes. In this study, we investigated whether the intrinsic functional connectivity of the DMN-C subnetwork is related to individual differences in memory ability, examining this relationship across 243 individuals (ages 18-50 years) from the openly available Cambridge Center for Aging and Neuroscience (Cam-CAN) dataset. We first estimated each participant’s whole-brain intrinsic functional brain connectivity by combining data from resting-state, movie-watching, and sensorimotor task scans to increase statistical power. We then examined whether intrinsic functional connectivity predicted performance on a narrative recall task. We found no evidence that functional connectivity of the DMN-C, with itself, with other related DMN subnetworks, or with the rest of the brain, was related to narrative recall. Exploratory connectome-based predictive modeling (CBPM) analyses of the entire connectome revealed a whole-brain multivariate pattern that predicted performance, although these changes were largely outside of known memory networks. These results add to emerging evidence suggesting that individual differences in memory cannot be easily explained by brain differences in areas typically associated with episodic memory function.
Speaker Competence Affects Prefrontal Theta and Occipital Alpha Power during Selective Word Learning in Preschoolers
Authors: Brehm Julia , Hoti Liridona , Sander Myriam C. , Werkle-Bergner Markus , Gampe Anja , Daum Moritz M. 
Published: April 2024

Abstract
In the present study, we investigated the cognitive processes underlying selective word learning in preschoolers. We measured rhythmic neural activity in the theta (4–8 Hz) and alpha frequency range (7–12 Hz) in 67 four-year-olds. EEG was recorded during anticipation and encoding of novel labeling events performed by a speaker who had previously shown either competence (correct) or incompetence (incorrect) in labeling familiar objects. In both groups, children selected the target object equally often upon recall. However, children observing the incompetent speaker revealed weaker representations of novel words indicated by an increased likelihood for selecting familiar but incorrect items upon recall. Modulations in theta and alpha power suggest differential processing of novel label–object pairs depending on the speakers' competence. In the incompetent, but not the competent, speaker condition, increases in prefrontal theta power during anticipation and encoding were related to increased recall success. Findings suggest that theta power in the present study reflects cognitive control. In both conditions, occipital alpha power—indicating attentional processes—reflected familiarity with novel items, but in opposite directions. In familiar item trials, alpha power was increased observing the incompetent and decreased observing the competent speaker. Thus, both cognitive control and attention processes during word learning are differentially affected by speaker characteristics.
Delta-band Activity Underlies Referential Meaning Representation during Pronoun Resolution
Authors: Ding Rong , Ten Oever Sanne , Martin Andrea E. 
Published: April 2024

Abstract
Human language offers a variety of ways to create meaning, one of which is referring to entities, objects, or events in the world. One such meaning maker is understanding to whom or to what a pronoun in a discourse refers to. To understand a pronoun, the brain must access matching entities or concepts that have been encoded in memory from previous linguistic context. Models of language processing propose that internally stored linguistic concepts, accessed via exogenous cues such as phonological input of a word, are represented as (a)synchronous activities across a population of neurons active at specific frequency bands. Converging evidence suggests that delta band activity (1–3 Hz) is involved in temporal and representational integration during sentence processing. Moreover, recent advances in the neurobiology of memory suggest that recollection engages neural dynamics similar to those which occurred during memory encoding. Integrating from these two research lines, we here tested the hypothesis that neural dynamic patterns, especially in delta frequency range, underlying referential meaning representation, would be reinstated during pronoun resolution. By leveraging neural decoding techniques (i.e., representational similarity analysis) on a magnetoencephalogram data set acquired during a naturalistic story-listening task, we provide evidence that delta-band activity underlies referential meaning representation. Our findings suggest that, during spoken language comprehension, endogenous linguistic representations such as referential concepts may be proactively retrieved and represented via activation of their underlying dynamic neural patterns.
The Longer Theology of Aristotle, Book X.14–17a: a Critical Edition and Translation
Authors: Treiger Alexander 
Published: April 2024

Abstract
The Longer Theology of Aristotle (LThA) is an interpolated version of the Theology of Aristotle (the latter being an Arabic adaptation of Plotinus’ Enneads IV–VI). LThA is preserved mainly in Judeo-Arabic manuscripts and a sixteenth-century Latin translation. Its importance lies in the fact that some non-Plotinian interpolations contained therein may be witnesses to lost Arabic philosophical sources (such as “Ibn Ḥasdāy’s Neoplatonist” postulated by Stern). The present study offers a critical edition and translation of LThA, Book X.14–17a. This passage contains several significant non-Plotinian interpolations. In particular, it exhibits a unique “Logos theology,” i.e., the idea that the divine “Logos” or “Word” (in Arabic: al-Kalima) constitutes an intermediary hypostasis between the Creator and His first creation, the Intellect. LThA shares this Logos theology with several Ismāʿīlī thinkers, notably the tenth-century Ismāʿīlī theologian Abū Yaʿqūb al-Sijistānī; in fact, the passage edited and translated herein (as well as the immediately preceding section: LThA, X.6–13) contains nearly-verbatim parallels to al-Sijistānī’s Kitāb al-Maqālīd. These parallels are presented in the Appendix.
ICESat-2 Shows Sea Ice Leads Have Little Overall Effects on the Arctic Cloudiness in Cold Months
Authors: Liu Zheng , Schweiger Axel 
Published: April 2024

Abstract
The effect of leads in Arctic sea ice on clouds is a potentially important climate feedback. We use observations of clouds and leads from the Ice, Cloud and Land Elevation Satellite-2 (ICESat-2) to study the effects of leads on clouds. Both leads and clouds are strongly forced by synoptic weather conditions, with more clouds over both leads and sea ice at lower sea level pressure. Contrary to previous studies, we find that the overall lead effect on low-level cloud cover is −0.02, a weak cloud dissipating effect in cold months, after the synoptic forcing influence is removed. This is due to compensating contributions from the cloud dissipating effect by newly frozen leads under high pressure systems and the cloud enhancing effect by newly open leads under low pressure system. The lack of proper representation of lead effect on clouds in current climate models and reanalyses may impact their performance in winter months, such as in sea ice growth and Arctic cyclone development.
Impact of Straight Stomach Reconstruction on Delayed Gastric Emptying and Nutritional Recovery After Pancreaticoduodenectomy
Authors: Iwanaga Naoki , Ito Yuzuru , Miyano Shozo , Machida Michio , Watanobe Ikuo , Sugo Hiroyuki 
Published: April 2024

Background The aim of this study was to evaluate the effectiveness of a modified reconstruction technique—anchored straight stomach reconstruction—in reducing the incidence of delayed gastric emptying (DGE) after pancreaticoduodenectomy (PD) and its impact on postoperative nutritional recovery. Methods A case series analysis of 125 consecutive PD patients was conducted: 104 of them had undergone anchored straight stomach reconstruction (SSR group) and the remaining 21 without (Non-SSR group). The incidence of DGE and the change in postoperative nutritional status (body weight and serum albumin level during 12 months post-surgery) were compared. Results The incidence of DGE in the SSR group (13%) was significantly lower than that in the Non-SSR group (33%) ( P = .018); further the significant DGE (grade B or C) was only 5%. Comparison of nutritional status showed that SSR facilitated a prompt recovery of body weight and serum albumin level at 6 months after PD. At 12 months after surgery, body weight gain was significantly better in the SSR group than in the Non-SSR group ( P = .006), and albumin level tended to be higher in the SSR group ( P = .071). Conclusion Straight stomach reconstruction is able to reduce DGE in patients after PD and also improves their postoperative nutritional recovery.
Rehabilitation for adult patients undergoing extracorporeal membrane oxygenation
Authors: Polastri Massimiliano , Eden Allaina , Swol Justyna 
Published: April 2024

Background and purpose Current information on the latest rehabilitative practices is limited, with previous reviews only covering data up to October 2021, and some considering only patients on awake ECMO or with COVID-19. This review aims to present a concise overview of the latest findings on rehabilitation and highlight emerging trends for patients undergoing ECMO support. Methods This integrative review was conducted by searching the National Library of Medicine – PubMed database. Two different search strings “extracorporeal membrane oxygenation” AND “rehabilitation” and “extracorporeal membrane oxygenation” AND “physiotherapy” were used to search the published literature. Articles that did not describe rehabilitation techniques, editorials, conference proceedings, letters to editor, reviews and research protocols were excluded. Studies conducted on pediatric populations were also excluded. The search process was completed in December 2023. Results Thirteen articles were included in the final analysis. Eight hundred and thirty-nine patients aged between 27 and 63 years were included; 428 were men (51%). In 31% of the included studies, patients had COVID-19; nevertheless, rehabilitative activities did not differ from non-COVID-19 patients. In most studies, rehabilitation commenced within the first 48–96 h and consisted of progressive exercise and out-of-bed activities such as sitting, standing and walking. Conclusion Current practice focuses on rehabilitative protocols that incorporate exercise routines with progressive intensity, greater emphasis on out-of-bed activities, and a multidisciplinary approach to patient mobilization.
Antibody drug conjugates: Design implications for clinicians
Authors: Pang Stephanie , Duong Arianne , Siu Chloe , Indorf Amy 
Published: April 2024

Objective There are currently 11 antibody-drug conjugates (ADC) that are FDA approved for use in oncologic disease states, with many more in the pipeline. The authors aim to review the pharmacokinetic profiles of the components of ADCs to engage pharmacist practitioners in practical considerations in the care of patients. This article provides an overview on the use of ADCs in the setting of organ dysfunction, drug–drug interactions, and management of on- and off-target adverse effects. Data Sources A systematic search of the literature on ADCs through September 2023 was conducted. Clinical trials as well as articles on ADC design and functional components, adverse effects, and pharmacokinetics were reviewed. Reviewed literature included prescribing information as well as tertiary sources and primary literature. Data Summary A total of 11 ADCs were reviewed for the purpose of this article. A description of the mechanism of action and structure of ADCs is outlined, and a table containing description of each currently FDA-approved ADC is included. Various mechanisms of ADC toxicity are reviewed, including how ADC structure may be implicated. Conclusion It is imperative that pharmacist clinicians understand the design and function of each component of an ADC to continue to assess new approvals for use in oncology patients. Understanding the design of the ADC can help a pharmacy practitioner compare and contrast adverse effect profiles to support their multidisciplinary teams and to engage patients in education and management of their care.
The Relationship Between Social Anxiety Disorder and ADHD in Adolescents and Adults: A Systematic Review
Authors: Jakobsson Støre Siri , Van Zalk Nejra , Granander Schwartz Wilma , Nilsson Victoria , Tillfors Maria 
Published: April 2024

Objective: This review aimed to systematically gather empirical data on the link between social anxiety disorder and ADHD in both clinical and non-clinical populations among adolescents and adults. Method: Literature searches were conducted in PsycInfo, PubMed, Scopus, and Web of Science, resulting in 1,739 articles. After screening, 41 articles were included. Results were summarized using a narrative approach. Results: The prevalence of ADHD in adolescents and adults with SAD ranged from 1.1% to 72.3%, while the prevalence of SAD in those with ADHD ranged from 0.04% to 49.5%. Studies indicate that individuals with both SAD and ADHD exhibit greater impairments. All studies were judged to be of weak quality, except for two studies which were rated moderate quality. Discussion: Individuals with SAD should be screened for ADHD and vice versa, to identify this common comorbidity earlier. Further research is needed to better understand the prevalence of comorbid ADHD and SAD in adolescents.
Risk factors of in-hospital mortality and discriminating capacity of NIVO score in exacerbations of COPD requiring noninvasive ventilation
Authors: Zhang Jiarui , Yi Qun , Zhou Chen , Luo Yuanming , Wei Hailong , Ge Huiqing , Liu Huiguo , Zhang Jianchu , Li Xianhua , Xie Xiufang , Pan Pinhua , Yi Mengqiu , Cheng Lina , Zhou Hui , Liu Liang , Aili Adila , Liu Yu , Peng Lige , Pu Jiaqi , Zhou Haixia ,   on behalf of the MAGNET AECOPD Registry Investigators
Published: April 2024

Background Noninvasive mechanical ventilation (NIV) is recommended as the initial mode of ventilation to treat acute respiratory failure in patients with AECOPD. The Noninvasive Ventilation Outcomes (NIVO) score has been proposed to evaluate the prognosis in patients with AECOPD requiring assisted NIV. However, it is not validated in Chinese patients. Methods We used data from the MAGNET AECOPD Registry study, which is a prospective, noninterventional, multicenter, real-world study conducted between September 2017 and July 2021 in China. Data for the potential risk factors of mortality were collected and the NIVO score was calculated, and the in-hospital mortality was evaluated using the NIVO risk score. Results A total of 1164 patients were included in the study, and 57 patients (4.9%) died during their hospital stay. Multiple logistic regression analysis revealed that age ≥75 years, DBP <60 mmHg, Glasgow Coma Scale ≤14, anemia and BUN >7 mmol/L were independent predictors of in-hospital mortality. The in-hospital mortality was associated with an increase in the risk level of NIVO score and the difference was statistically significant ( p < .001). The NIVO risk score showed an acceptable accuracy for predicting the in-hospital mortality in AECOPD requiring assisted NIV (AUC: 0.657, 95% CI: 0.584-0.729, p < .001). Conclusion Our findings identified predictors of mortality in patients with AECOPD receiving NIV, providing useful information to identify severe patients and guide the management of AECOPD. The NIVO score showed an acceptable predictive value for AECOPD receiving NIV in Chinese patients, and additional studies are needed to develop and validate predictive scores based on specific populations.