bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical Coherence Tomography Predictors of Retinal Pigment Epithelial Tear Following Intravitreal Bevacizumab Injection
Authors: Moroz Iris , Moisseiev Joseph , Alhalel Amir 
Published: November 2009

Background and Objective:
To evaluate the ability of optical coherence tomography (OCT) to predict the risk of retinal pigment epithelium (RPE) tear in patients with choroidal neovascular membrane associated with pigment epithelium detachment treated with bevacizumab.

Patients and Methods:
Retrospective observational case series of 24 consecutive patients treated with bevacizumab. All patients had sequential OCT scans performed before treatment and during follow-up. Six patients developed an RPE tear. Eighteen patients served as the non-tear group.

Results:

Wavy RPE indentations or small interruptions and breaks in the elevated RPE were evident in all six patients who developed an RPE tear, whereas only two of the remaining 18 patients had such findings (
P
< .001).

Conclusion:
Indentations or minute interruptions and breaks in the RPE layer seen on OCT were correlated with increased risk of developing an RPE tear in patients with pigment epithelium detachment following treatment with bevacizumab.

[Ophthalmic Surg Lasers Imaging 2009;40:570–575.]
Polypoidal Choroidal Vasculopathy in Taiwanese Patients
Authors: Chang Yo-Chen , Wu Wen-Chuan 
Published: November 2009

Background and Objective:
To investigate the incidence of polypoidal choroidal vasculopathy (PCV) in patients with presumed neovascular age-related macular degeneration (AMD) using indocyanine green angiography (ICGA). The efficacy of photodynamic therapy (PDT) with verteporfin in eyes with PCV and neovascular AMD was also evaluated.

Patients and Methods:
The medical records of 100 patients with neovascular AMD diagnosed according to ICGA findings were reviewed. Patients who underwent PDT were scheduled for follow-up appointments every 2 months.

Results:

Forty-nine (49.0%) and 51 (51.0%) patients were diagnosed as having PCV and neovascular AMD, respectively. The mean age of presentation was younger in the PCV group than in the neovascular AMD group (63.6 vs 69.7 years, respectively;
P
= .002). There were 35 men (71.4%) in the PCV group and 37 men (72.5%) in the neovascular AMD group. Seventeen patients (33.3%) with neovascular AMD had bilateral involvement compared with only 4 patients (8.2%) with PCV (
P
= .004). Twenty eyes with PCV and 22 eyes with neovascular AMD received one PDT treatment. After PDT, 10 eyes (50%) with PCV and 11 eyes (50%) with neovascular AMD experienced visual improvement.

Conclusion:
PCV is not uncommon in Taiwanese patients diagnosed as having neovascular AMD by ICGA and these patients have a younger age of onset, male predominance, unilateral involvement, and macular polyps. Both PCV and neovascular AMD can achieve favorable visual improvement following PDT with verteporfin.

[Ophthalmic Surg Lasers Imaging 2009;40:576–581.]
Polycythemia vera and essential thombocythemia - A single institution experience
Authors: Ross Cecil , Rameshkumar Karuna ,   Navya,   Vanamala
Published: November 2009

Abstract
Background: In myeloproliferative disorders, occurrence of Janus kinase 2 [JAK2] mutation is a significant factor in pathogenesis in polycythemia rubra vera (PRV) and Essential thrombocythemia (ET). We studied the frequency of JAK2 mutation in patients with PRV and ET and to compare clinical and laboratory features of patients positive and negative for mutation. Patients and Methods: Clinical and laboratory features of PRV and ET patients (WHO criteria) from 1997 to 2004 were included. After morphological diagnosis, presence or absence of JAK 2 mutation was done during follow up and follow up details were recorded. Results: A cohort of 39 patients (ET-17, PRV -14, ET- PRV-8) were identified .The mean age of entire cohort was 55.5+14.5 years. Comparison of clinical and laboratory features showed JAK2 positive patients were older by a decade, had higher frequency of splenomegaly and higher values for hemoglobin (16.5+2.6 gm/dl) and neutrophil counts (14.5+4.8 thousand/μl).During the course of follow up (6 to 106 months; mean 25.5+28.6 months) frequency of thrombotic events in both groups (p value >0.05) was same, though time for occurrence for thrombotic event was shorter in JAK 2 positive patients, which is noteworthy. Conclusions: The identification of JAK 2 mutation probably defines a sub entity in ET with aggressive behavior as evidenced by splenomegaly, higher total counts and transformation to PRV (n=6/8). The onset of JAK2 V617F mutation probably heralds progression to PRV.
Chemoradiation in locally advanced cervical cancer : A randomized trial
Authors: Kundu Sayan , Basu S , Acharya S , Dastidar A , Roy A G 
Published: November 2009

Abstract
Background: Radiation with concurrent chemotherapy (weekly cisplatin) is currently standard of care for locally advanced cervical cancer. Gemcitabine, a pyrimidine analogue is a potentially radio-sensitizing drug. We compared cisplatin and gemcitabine in the treatment of locally advanced cervical cancer. Methods: 90 patients with locally advanced squamous cell cancer of the cervix (stage IIB-IVA) were randomized to receive either cisplatin 40mg/m2 weekly or gemcitabine 150 mg/m2 weekly (45 patients in each arm) along with external beam radiation (50Gy in 25# over 5 weeks). This was followed by three insertions of high dose radiation (HDR) intracavitary brachytherapy one week apart. Results: At a median follow up of 13months, 25 (55.56%) patients were in complete response (CR) in the cisplatin arm compared to 22 patients (48.89%) [p=0.67] in gemcitabine arm. 10 patients (22.22%) in cisplatin arm had either died or lost to follow up compared to 11 patients in gemcitabine (24.44%) arm. Nausea/vomiting was higher in cisplatin arm. Diarrhea, skin reaction and hematological toxicity were more in gemcitabine arm. Conclusion: Cisplatin seems to be a better option than gemcitabine when used concurrently with radiation for locally advanced cervical cancer both in terms of response and toxicity.
Squamous cell carcinoma in bladder extrophy
Authors: Haji Altaf Gauhar , Chitrathara K , Sharma Shekhar , Vijaykumar D , Gangadharan V 
Published: November 2009

AbstractExtrophy of the bladder is a rare congenital anomaly with an incidence of about 1/50000 newborn. Malignant potential of ectopic mucosa is high. Sixty percent of cancers in ectopic bladder occur during fourth and fifth decade of life, majority being adenocarcinoma (95%). Here we report a case of squamous cell carcinoma of ectopic urinary bladder in a 74-year-old male patient. In view of locally advanced disease, he received neoadjuvant chemotherapy with poor response. He underwent total cystectomy with ileal conduit diversion and continues to be alive and disease free at 36 months interval. The case is being reported on account of its rarity. Pertinent literature is being reviewed.
Merkel cell carcinoma of skin
Authors: Janaki M , Koushik Kirthi , Baby Rekha , Kempiah Venkatesh 
Published: November 2009

AbstractMerkel cell carcinoma is a rare neuroendocrinal tumour of the skin. It is noted for its typical aggressive nature unlike other skin tumours. Because of the rarity, the treatment is not standardised. Radiotherapy in the postoperative setting is effective in improving the loco regional control. A case of merkel cell carcinoma treated with postoperative radiotherapy is reported. Pertinent literature is reviewed.
Uncommon manifestations of acute lymphoblastic leukaemia (ALL)
Authors: Gomber Sunil , Narang Manish , Dhaliwal Upreet 
Published: November 2009

AbstractUnusual manifestations often lead to misdiagnosis of patients with acute lymphoblastic leukemia (ALL). We describe two children with ALL having unusual associations. The first case presented with pseudohypopyon after 18 months into her maintenance therapy whereas the other case masqueraded as juvenile rheumatoid arthritis at presentation.
Epstein-barr virus in gastric lymphoma- An Indian perspective
Authors: Sood Abhay , Braganza Abhita , Rajalakshmi T 
Published: November 2009

AbstractBackground: Primary Gastric Non- Hodgkin′s Lymphomas (NHL) are being increasingly encountered in the recent years. While the role of Helicobacter pylori (H. pylori) has been explored in its causation, some studies have suggested the role of the Epstein - Barr virus (EBV). However data from India is not readily available and this prompted us to study the morphology of primary gastric NHL, the prevalence of EBV infection in primary Gastric NHL and study its association with H. pylori infection. Materials& Methods: A retrospective study. Sixteen biopsy proven cases of primary gastric NHL were studied. Histologic features were reviewed. Immunohistochemistry for EBV LMP-1 and Modified Giemsa stain to identify Helicobacter pylori were done. Results: There were 10 low-grade and 6 highgrade lymphomas, 15 of them classifiable as Mucosa-associated lymphoid tissue (MALT) type, owing to the presence of lymphoepithelial lesions. 36% of the cases were EBV positive. Only one case showed H. pylori. 4 patients succumbed to the disease, of which 3 were seropositive for HIV. Conclusion: Our pilot study suggests that EBV may have an important role in the pathogenesis of gastric MALT lymphomas. The significance of this association and its prognostic value need to be explored in larger number of patients.
An unusual penile spindle cell malignancy
Authors: Francis Anju , Rajalakshmi T , Garg Isha , Mohanty Suravi , Anuradha A , Rout Pritilata , Mohan A 
Published: November 2009

AbstractPrimary non-epithelial malignancies of the penis are rare. We report a patient with an unusual presentation of an unexpected spindle cell malignancy at this site. A 35- year-old man presented with a mass in the shaft of the penis with inguinal lymphadenopathy. A malignant spindle cell neoplasm was seen involving the corpora, consistent with leiomyosarcoma. Immunohistochemically, the tumour was positive for S100, HMB-45 and negative for SMA. A final diagnosis of amelanotic spindle cell melanoma was made. This case is being presented to reiterate the importance of including melanoma in the differential diagnosis of spindle cell sarcomas at uncommon sites.
Significance of haemostatic markers in ovarian carcinoma
Authors: Sitalakshmi S , Rameshkumar Karuna , Damodar Prema 
Published: November 2009

Abstract
Background: Most cancer patients with metastatic disease have abnormal coagulation parameters. Although many abnormal blood coagulation tests have been reported in malignancies, there is little agreement regarding which tests are most useful to predict disease progression and hence this study was undertaken. Methods: In this prospective study, baseline and special coagulation tests were performed on 23 patients with ovarian adenocarcinoma. The baseline tests were PT, APTT, TT and platelet count. The special tests included factor VIII, factor IX and fibrinogen assay and semiquantitative measurement of D-dimer and FDP levels The cases were grouped into early and advanced disease groups. The results of the coagulation tests were analysed using suitable statistical methods. The results were compared between limited and advanced disease by chi square and Mann Whitney U test Results: The percentage of cases with increased D-dimer and fibrin degradation products (FDP) values were higher in the advanced disease compared to early disease. Two cases in stage IV had DIC. The PT, APTT, TT and platelet count did not show any statistically significant differences between the early and advanced disease groups. Factor VIII, factor IX and fibrinogen levels were not significantly different between two groups. Conclusion: Elevated D dimer& FDP are associated with advanced stage ovarian adenocarcinoma.
An ayurvedic herbal compound to reduce toxicity to cancer chemotherapy: A randomized controlled trial
Authors: Saxena Abha , Dixit Smita , Aggarwal Sandeep , Seenu Vuthaluru , Prashad Rajinder , Bhushan S , Tranikanti Varna , Misra M , Srivastava Anurag 
Published: November 2009

Abstract
Background: Maharishi Amrit Kalash (MAK) is an ayurvedic compound containing many herbs rich in antioxidants. We evaluated its role in reduction of chemotherapy toxicity among women with breast cancer. Patient and Methods:We recruited 214 patients with breast carcinoma receiving cyclophosphamide, methotrexate and 5- flourouracil (CMF) or cyclophosphamide, adriamycine,& 5-flourouracil (CAF), adjuvant or neo-adjuvant chemotherapy. The toxicity of chemotherapy was assessed according to WHO criteria. Statistical analysis was carried out on Epi-info 6 and STATA-7. All patients received same antiemetic therapy with ondensetron and dexamethasone. Results:There was a significant reduction in toxicities observed in MAK group throughout chemotherapy cycles: Poor performance status was prevented by concomitant administration of MAK along with chemotherapy.(Prevented Fraction (PF)=60.6% (95% confidence interval 22.1 to 80.1 ; p value =0.005 ). Vomiting was prevented by MAK {PF=40.3%, (95% confidence interval 15.1 to 58.1; p value=0.002)}. Similarly anorexia was reduced with PF= 35.6%. (95% confidence interval 17.6 to 49.7, p value = 0.0001) in MAK group. No improvement occurred in stomatitis, diarrhea, alopecia and leucopenia. No overgrowth of tumours occurred in the group treated with Neoadjuvant chemotherapy receiving MAK. Conclusion:MAK may be used as a supplement along with chemotherapeutic drugs for reducing chemotherapy induced vomiting, anorexia and improving general well being of patients.
Triple negative breast cancer with isolated leptomeningeal metastasis
Authors: Sampathkumar N , Sambasivaiah K , Naga M ,   Ramakrishna
Published: November 2009

AbstractIsolated Leptomeningeal metastasis in breast cancer is rare. The diagnosis requires T1W MR scan of brain with gadolinium enhancement and demonstration of malignant cells in CSF. The treatment is palliative, which includes whole brain radiotherapy and chemotherapy.
Papillary carcinoma of thyroid in a 11 months old child
Authors: Poddar Soumita , Basu Siddhartha , Majumder Anup ,   Devleena
Published: November 2009

AbstractCarcinoma of thyroid gland is rare in pediatric age group before the age of 15 years. A 11 months old child presented with swelling in midline of neck which showed cold nodule on thyroid scan. On fine needle aspiration biopsy (FNAC) papillary carcinoma of thyroid was detected and the patient underwent subtotal thyroidectomy followed by radioiodine ablation and thyroid supplementation. The case is being reported on account of its rarity.
Childhood follicular non-hodgkin′s lymphoma: A case report and review of literature
Authors: Agarwal Shipra , Das Prasenjit , Karak A , Kumar Lalit , Ray Ruma 
Published: November 2009

AbstractThe majorities of non-Hodgkin′s lymphomas in children are lymphoblastic lymphoma, Burkitt′s lymphoma, anaplastic large cell lymphoma and diffuse large B-cell lymphoma. Follicular lymphoma is primarily a disease of adulthood with a median age of 59 years. It is rare in pediatric patients. Childhood follicular lymphoma differs from its adult counterpart in several aspects. We report a rare case of childhood low grade mature B-cell non- Hodgkin′s lymphoma wherein the tumour cells were CD20 +, focally bcl-6 +, CD3 -, CD5 -, CD10 -, CD23 -, Cyclin D1 -, bcl-2 -, and had a low ki-67 proliferation index. A diagnosis of follicular lymphoma was made on the basis of the focal bcl-6 positivity. Despite non-intervention in the form of chemotherapy or radiotherapy, the patient remained symptom free even after a followup of 39 months. This case is being reported for its rarity. This is one of the initial case reports on follicular lymphoma in pediatric age group from the Indian subcontinent.
Supraglottic carcinoma with skeletal muscle and multiple bone secondaries
Authors: Gupta Surabhi , Arya A , Kumar Anuj , Chaudhary Sandeep , Chauhan Bhupendra , Gupta Anurag 
Published: November 2009

AbstractSoft tissue and bone secondaries in supraglottic carcinoma are extremely rare. A 55 year old male presented with history of hoarseness of voice, lump in left side of neck and pain in right shoulder region. Patient underwent Radiotherapy to primary as well as metastatic sites. After 10 months of follow-up, patient presented with distant metastasis to left shoulder, lumbar vertebra and sacrum. This case is being reported on account of its rarity.
Risk factors for gallbladder cancer : A population based case-control study in Delhi
Authors: Tyagi B B , Manoharan N , Raina V 
Published: November 2009

Abstract
Background : Gallbladder (GB) cancer ranks among the first five common cancers in females in Delhi, India. The incidence rate of GB carcinoma is higher in North India compared to South India. Methods : A population based case-control study on 333 GB incident cases was carried out in Delhi to identify the risk factors. Cases were matched with two controls based on age (± 5 years), sex and marital status (in case of females) Results : Smoking and alcohol consumption increase the risk of GB cancer. The risk among those who smoke cigarette (OR=3.05, CI=1.33-6.98) was higher than that seen among bidi smokers (OR=2.25, CI=1.38-3.69). History of typhoid in the past and cholelithiasis increased the risk of GB cancer. Post menopausal women had a significant risk of GB cancer than the menstruating women. Consumption of urad dhal, moong dhal, milk, cottage cheese and butter also increased the risk of GB cancer. Conclusion : Smoking, alcohol consumption, typhoid in the past, cholelithiasis and certain dietary items are the some of the most important risk factors for gallbladder cancer.
Multiple myeloma mimicking bone metastasis in a patient of carcinoma breast
Authors: Hingmire Sheetal , Hingmire Sachin , Bakshi Ashish , Gujaral Sumeet , Badwe Rajan , Nair Reena 
Published: November 2009

AbstractSecond malignancies or co-existing malignancies like ovarian, endometrial, lung carcinomas, soft tissue sarcomas have been reported to be associated with breast carcinoma. The commonest cause of bone pain in a patient of breast cancer is metastasis to bone. We present a rare case of multiple myeloma mimicking bony metastasis in a patient of breast carcinoma.
Large granular lymphocytic leukemia
Authors: Rasool Javid , Jeelani Samoon , Geelani Sajad , Lone Abdul , Shaban Mohd 
Published: November 2009

AbstractLarge granular lymphocytic leukemia (LGL) affects adults and is rare in children, etiology being unknown. We describe a case of a fourteen year old boy who presented with symptomatic anemia with lymphocytosis and atypical lymphocytes. Bone marrow revealed hypocellularity with marked erythroid hypoplasia, lymphocytosis and increased eosinophils. Immunohistochemistry confirmed the diagnosis of LGL.
Recombinant Protein Purification by Self‐Cleaving Elastin‐like Polypeptide Fusion Tag
Authors: Wu Wan‐Yi , Fong Baley A. , Gilles Allison G. , Wood David W. 
Published: November 2009

AbstractThis unit presents a rapid and simple method for the nonchromatographic purification of recombinant proteins expressed in E. coli. This method relies on a thermally responsive elastin‐like polypeptide (ELP) tag, where the tagged protein is precipitated using a mild temperature shift. The tag is then induced to self‐cleave by a mild pH shift and is subsequently removed by a final thermal precipitation. The result is a purified native protein target, without the requirement for affinity apparatus or protease removal of the tag. This protocol describes the required cloning methods to insert a given target into the expression vector, as well as the general method for purifying the resulting expressed protein. Curr. Protoc. Protein Sci. 58:26.4.1‐26.4.18. © 2009 by John Wiley & Sons, Inc.
Faceted Surface Grain Morphology of Rapidly Solidified Alumina: Characterization and Potential Applications
Authors: Harimkar Sandip P. , Kenik Edward A. , Shim Sanghoon , Dahotre Narendra B. 
Published: November 2009

AbstractThe study reports on the formation of regular multi‐faceted surface grains during laser surface modification of alumina ceramics. The formation of such faceted morphology of the grains can be strongly correlated with the formation of crystallographic texture. Such evolution of crystallographically‐textured, multi‐faceted grains opens up new avenues for laser surface modification, where regular three dimensional surface features are formed through solidification processing.
Highly Stable Au Nanoparticles with Tunable Spacing and Their Potential Application in Surface Plasmon Resonance Biosensors
Authors: Gao Shuyan , Koshizaki Naoto , Tokuhisa Hideo , Koyama Emiko , Sasaki Takeshi , Kim Jae‐Kwan , Ryu Joonghyun , Kim Deok‐Soo , Shimizu Yoshiki 
Published: November 2009

AbstractColloidal Au‐amplified surface plasmon resonance (SPR), like traditional SPR, is typically used to detect binding events on a thin noble metal film. The two major concerns in developing colloidal Au‐amplified SPR lie in 1) the instability, manifested as a change in morphology following immersion in organic solvents and aqueous solutions, and 2) the uncontrollable interparticle distance, determining probe spacing and inducing steric hindrance between neighboring probe molecules. This may introduce uncertainties into such detecting techniques, degrade the sensitivity, and become the barricade hampering colloidal Au‐based transducers from applications in sensing. In this paper, colloidal Au‐amplified SPR transducers are produced by using ultrathin Au/Al2O3 nanocomposite films via a radio frequency magnetron co‐sputtering method. Deposited Au/Al2O3 nanocomposite films exhibit superior stability, and average interparticle distances between Au nanoparticles with similar average sizes can be tuned by changing surface coverage. These characteristics are ascribed to the spacer function and rim confinement of dielectric Al2O3 and highlight their advantages for application in optimal nanoparticle‐amplified SPR, especially when the probe size is smaller than the target molecule size. This importance is demonstrated here for the binding of protein (streptavidin) targets to the probe (biotin) surface. In this case, the dielectric matrix Al2O3 is a main contributor, behaving as a spacer, tuning the concentration of Au nanoparticles, and manipulating the average interparticle distance, and thus guaranteeing an appropriate number of biotin molecules and expected near‐field coupling to obtain optimal sensing performance.
Palladium‐Catalyzed Sequential Reactions via Allene Intermediates for the Rapid Synthesis of Fused Polycyclic Pyrrole Derivatives
Authors: Huang Xian , Zhu Shugao , Shen Ruwei 
Published: November 2009

AbstractIn this paper, we report a novel sequential reaction sequence consisting of a series of processes including Sonogashira coupling, propargyl‐allenyl isomerization, [3+2] cycloaddition, denitrogenation, and highly selective biradical coupling reaction, providing an efficient synthesis of fused polycyclic pyrrole derivatives. The reaction features one CC bond and two CN bonds formed to construct the pyrrole unit, together with two rings efficiently assembled in one stroke.
Amelia, cleft lip, and holoprosencephaly: A distinct entity
Authors: Kariminejad Ariana , Goodarzi Payman , Asghari‐Roodsari Alaleh , Kariminejad Mohamad Hasan 
Published: November 2009

AbstractWe report on a male fetus with amelia, cleft lip, and holoprosencephaly. We compare the clinical findings in our patient with those of previously reported cases with the most clinical overlap. To date only four cases with bilateral limb amelia, CNS anomalies, and facial clefts have been described. Our report appears to represent the fifth case with such a combination of anomalies. © 2009 Wiley‐Liss, Inc.