bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin of Distinct Insulating Domains in the Layered Charge Density Wave Material 1T‐TaS2
Authors: Yang Hyungryul , Lee Byeongin , Bang Junho , Kim Sunghun , Wulferding Dirk , Lee Sung‐Hoon , Cho Doohee 
Published: May 2024

AbstractVertical charge order shapes the electronic properties in layered charge density wave (CDW) materials. Various stacking orders inevitably create nanoscale domains with distinct electronic structures inaccessible to bulk probes. Here, the stacking characteristics of bulk 1T‐TaS2 are analyzed using scanning tunneling spectroscopy (STS) and density functional theory (DFT) calculations. It is observed that Mott‐insulating domains undergo a transition to band‐insulating domains restoring vertical dimerization of the CDWs. Furthermore, STS measurements covering a wide terrace reveal two distinct band insulating domains differentiated by band edge broadening. These DFT calculations reveal that the Mott insulating layers preferably reside on the subsurface, forming broader band edges in the neighboring band insulating layers. Ultimately, buried Mott insulating layers believed to harbor the quantum spin liquid phase are identified. These results resolve persistent issues regarding vertical charge order in 1T‐TaS2, providing a new perspective for investigating emergent quantum phenomena in layered CDW materials.
A Bioactive Injectable Hydrogel Regulates Tumor Metastasis and Wound Healing for Melanoma via NIR‐Light Triggered Hyperthermia
Authors: Liu Xueyi , Shen Meifang , Bing Tiejun , Zhang Xinyun , Li Yifan , Cai Qing , Yang Xiaoping , Yu Yingjie 
Published: May 2024

AbstractSurgical resection remains the mainstream treatment for malignant melanoma. However, challenges in wound healing and residual tumor metastasis pose significant hurdles, resulting in high recurrence rates in patients. Herein, a bioactive injectable hydrogel (BG‐Mngel) formed by crosslinking sodium alginate (SA) with manganese‐doped bioactive glass (BG‐Mn) is developed as a versatile platform for anti‐tumor immunotherapy and postoperative wound healing for melanoma. The incorporation of Mn2+ within bioactive glass (BG) can activate the cGAS‐STING immune pathway to elicit robust immune response for cancer immunotherapy. Furthermore, doping Mn2+ in BG endows system with excellent photothermal properties, hence facilitating STING activation and reversing the tumor immune‐suppressive microenvironment. BG exhibits favorable angiogenic capacity and tissue regenerative potential, and Mn2+ promotes cell migration in vitro. When combining BG‐Mngel with anti‐PD‐1 antibody (α‐PD‐1) for the treatment of malignant melanoma, it shows enhanced anti‐tumor immune response and long‐term immune memory response. Remarkably, BG‐Mngel can upregulate the expression of genes related to blood vessel formation and promote skin tissue regeneration when treating full‐thickness wounds. Overall, BG‐MnGel serves as an effective adjuvant therapy to regulate tumor metastasis and wound healing for malignant melanoma.
Logic‐Based Strategy for Spatiotemporal Release of Dual Extracellular Vesicles in Osteoarthritis Treatment
Authors: Li Shiyu , Zheng Weihan , Deng Wenfeng , Li Ziyue , Yang Jiaxin , Zhang Huihui , Dai Zhenning , Su Weiwei , Yan Zi , Xue Wanting , Yun Xinyi , Mi Siqi , Shen Jianlin , Luo Xiang , Wang Ling , Wu Yaobin , Huang Wenhua 
Published: May 2024

AbstractTo effectively treat osteoarthritis (OA), the existing inflammation must be reduced before the cartilage damage can be repaired; this cannot be achieved with a single type of extracellular vesicles (EVs). Here, a hydrogel complex with logic‐gates function is proposed that can spatiotemporally controlled release two types of EVs: interleukin 10 (IL‐10)+ EVs to promote M2 polarization of macrophage, and SRY‐box transcription factor 9 (SOX9)+ EVs to increase cartilage matrix synthesis. Following dose‐of‐action screening, the dual EVs are loaded into a matrix metalloporoteinase 13 (MMP13)‐sensitive self‐assembled peptide hydrogel (KM13E) and polyethylene glycol diacrylate/gelatin methacryloyl‐hydrogel microspheres (PGE), respectively. These materials are mixed to form a “microspheres‐in‐gel” KM13E@PGE system. In vitro, KM13E@PGE abruptly released IL‐10+ EVs after 3 days and slowly released SOX9+ EVs for more than 30 days. In vivo, KM13E@PGE increased the CD206+ M2 macrophage proportion in the synovial tissue and decreased the tumor necrosis factor‐α and IL‐1β levels. The aggrecan and SOX9 expressions in the cartilage tissues are significantly elevated following inflammation subsidence. This performance is not achieved using anti‐inflammatory or cartilage repair therapy alone. The present study provides an injectable, integrated delivery system with spatiotemporal control release of dual EVs, and may inspire logic‐gates strategies for OA treatment.
Memorizable Electro‐Birefringence Effect Exhibited by Transparent Liquid Crystal/Polymer Composite Materials
Authors: Yamaguchi Masaki , Okumura Yasushi , Nishikawa Hiroya , Matsukizono Hiroyuki , Kikuchi Hirotsugu 
Published: May 2024

AbstractPolymer‐dispersed liquid crystals (PDLCs) with nano‐phase‐separated structures, in which nanometer‐sized liquid crystal (LC) domains are dispersed within a polymer matrix (nano‐PDLCs), are transparent solid materials whose optical properties can be modulated by applying an electric field (E‐field). Because the proportion of LC that can respond to an electric field is small, the specific surface area of the phase‐separated interface of nano‐PDLCs is larger than that of conventional PDLCs, resulting in higher drive voltages than those of conventional PDLCs. To lower the driving voltage of nano‐PDLCs, highly polar LCs (C3DIO) are used with a large dielectric anisotropy (>10000), and prepared nano‐PDLCs using DIO mixtures obtained by mixing them with related compounds as the host LC. Nano‐PDLCs employing DIO mixtures exhibit higher E‐field responsivity than those using conventional LC. In addition, the electro‐optical Kerr coefficient at visible wavelength is significantly high, reaching 10−8 m V−2. Furthermore, nano‐PDLCs using the DIO mixture exhibit a memory effect in which the induced birefringence remains even after the removal of the in‐plane E‐field. Memorized birefringence can be erased by heating or applying an E‐field perpendicular to the substrate surface. Nano‐PDLCs using a DIO mixture can be rewritable electro‐birefringence‐responsive materials that can memorize arbitrary birefringence values.
Towards a species‐level phylogeny for Neotropical Myrtaceae: Notes on topology and resources for future studies
Authors:   The Neotropical Myrtaceae Working Group, Staggemeier Vanessa G. , Amorim Bruno , Bünger Mariana , Costa Itayguara R. , de Faria Jair Eustáquio Quintino , Flickinger Jonathan , Giaretta Augusto , Kubo Marcelo T. , Lima Duane Fernandes , dos Santos Leidiana Lima , Lourenço Ana Raquel , Lucas Eve , Mazine Fiorella Fernanda , Murillo‐A José , de Oliveira Marla Ibrahim Uehbe , Parra‐O Carlos , Proença Carolyn E. B. , Reginato Marcelo , Rosa Priscila Oliveira , Santos Matheus Fortes , Stadnik Aline , Tuler Amélia Carlos , Valdemarin Karinne Sampaio , Vasconcelos Thais 
Published: May 2024

AbstractPremiseIncreasingly complete phylogenies underpin studies in systematics, ecology, and evolution. Myrteae (Myrtaceae), with ~2700 species, is a key component of the exceptionally diverse Neotropical flora, but given its complicated taxonomy, automated assembling of molecular supermatrices from public databases often lead to unreliable topologies due to poor species identification.MethodsHere, we build a taxonomically verified molecular supermatrix of Neotropical Myrteae by assembling 3909 published and 1004 unpublished sequences from two nuclear and seven plastid molecular markers. We infer a time‐calibrated phylogenetic tree that covers 712 species of Myrteae (~28% of the total diversity in the clade) and evaluate geographic and taxonomic gaps in sampling.ResultsThe tree inferred from the fully concatenated matrix mostly reflects the topology of the plastid data set and there is a moderate to strong incongruence between trees inferred from nuclear and plastid partitions. Large, species‐rich genera are still the poorest sampled within the group. Eastern South America is the best‐represented area in proportion to its species diversity, while Western Amazon, Mesoamerica, and the Caribbean are the least represented.ConclusionsWe provide a time‐calibrated tree that can be more reliably used to address finer‐scale eco‐evolutionary questions that involve this group in the Neotropics. Gaps to be filled by future studies include improving representation of taxa and areas that remain poorly sampled, investigating causes of conflict between nuclear and plastid partitions, and the role of hybridization and incomplete lineage sorting in relationships that are poorly supported.
Ponatinib‐review of historical development, current status, and future research
Authors: Kantarjian Hagop M. , Chifotides Helen T. , Haddad Fadi G. , Short Nicholas J. , Loghavi Sanam , Jabbour Elias 
Published: May 2024

AbstractPonatinib is a third‐generation BCR::ABL1 tyrosine kinase inhibitor (TKI) with high potency against Philadelphia chromosome (Ph)‐positive leukemias, including T315I‐mutated disease, which is resistant to first‐ and second‐generation TKIs. Ponatinib was approved for T315I‐mutated chronic myeloid leukemia (CML), CML resistant/intolerant to ≥2 prior TKIs, advanced phase CML and Ph‐positive acute lymphoblastic leukemia (ALL) where no other TKIs are indicated, and T315I‐mutated CML and Ph‐positive ALL. The response‐based dosing of ponatinib in chronic phase CML (CP‐CML) improved treatment tolerance and reduced the risk of toxicities, including cardiovascular risks. Ponatinib‐based therapy also resulted in significantly better outcomes in frontline Ph‐positive ALL compared with prior TKIs and is becoming a new standard of care in this setting. As the clinical development of third‐generation TKIs and their rational combinations progresses, we envision further transformative changes in the treatment of CML and Ph‐positive ALL.
Next‐generation phenotyping in Nigerian children with Cornelia de Lange syndrome
Authors: Arlt Annabelle , Knaus Alexej , Hsieh Tzung‐Chien , Klinkhammer Hannah , Bhasin Meghna Ahuja , Hustinx Alexander , Moosa Shahida , Krawitz Peter , Ekure Ekanem 
Published: May 2024

AbstractNext‐generation phenotyping (NGP) can be used to compute the similarity of dysmorphic patients to known syndromic diseases. So far, the technology has been evaluated in variant prioritization and classification, providing evidence for pathogenicity if the phenotype matched with other patients with a confirmed molecular diagnosis. In a Nigerian cohort of individuals with facial dysmorphism, we used the NGP tool GestaltMatcher to screen portraits prior to genetic testing and subjected individuals with high similarity scores to exome sequencing (ES). Here, we report on two individuals with global developmental delay, pulmonary artery stenosis, and genital and limb malformations for whom GestaltMatcher yielded Cornelia de Lange syndrome (CdLS) as the top hit. ES revealed a known pathogenic nonsense variant, NM_133433.4: c.598C>T; p.(Gln200*), as well as a novel frameshift variant c.7948dup; p.(Ile2650Asnfs*11) in NIPBL. Our results suggest that NGP can be used as a screening tool and thresholds could be defined for achieving high diagnostic yields in ES. Training the artificial intelligence (AI) with additional cases of the same ethnicity might further increase the positive predictive value of GestaltMatcher.
Simultaneous sensing of carbidopa and levodopa by a novel strategy based on dual‐emission ratiometric assay of modified carbon dots
Authors: Abbasi Majd Sasan , Kashanian Soheila , Shekarbeygi Zahra , Babaei Mahsa 
Published: May 2024

AbstractRapid control of the content of Parkinson's drugs in biological fluids and pharmaceutical formulations is of great importance because changes in the concentration of these drugs affect their bioavailability and biopharmaceutical properties. Therefore, we presented a simple and convenient method for the ratiometric detection of carbidopa and levodopa for carbon dots (CDs) dual‐fluorescent emission. Dual‐emission CDs were prepared from chitosan using a microwave method, following which the surface was chemically modified with terephthalaldehyde. CDs had two strong well‐separated peaks at 445 and 510 nm. The relative measurement of carbidopa and levodopa was based on the static extinction of CDs at 445 nm and increase at 510 nm, respectively. The linear range for carbidopa measurement was 2.5–300 nM, with a limit of detection (LOD) of 2.1 nM, and a relative standard deviation (RSD) of 1.68%. Further, the linear range for levodopa measurement was equal to 3.0–400 nM, with LOD and RSD% of 2.8 nM and 3.5%, respectively. Also, selectivity of ratiometric sensor in the presence of interferences was investigated, which showed that the recovery of carbidopa and levodopa in serum and urine samples has changed between 96.80% and 116.24% with RSD% 0.11–0.77. CDs also provided good results for the determination of carbidopa and levodopa in real samples, and had high selectivity in the presence of possible interferences.
Influence of antioxidants from pequi leaves on the thermal and oxidative stability of biodiesel
Authors: Irineu Ranuir Lucas de Oliveira , Silva Victor Juan Rodrigues da , Nogueira Josiane da Rocha Ferreira , Merlo Thais Cardoso , Rial Rafael Cardoso 
Published: May 2024

AbstractIn this study, the efficacy of antioxidants found in pequi leaves was examined for safeguarding pequi biodiesel (EBP) against oxidation. The results reveal notable achievements. The antioxidant activity of AFP (a pequi leaf antioxidant additive) was assessed at various concentrations, demonstrating that as the concentration of AFP increases, the inhibition percentage significantly rises, reaching a remarkable inhibition of 99.12% at 100 mg L−1, with a calculated IC50 of 25.4 mg L−1. Additionally, the analysis of the AFP composition revealed the presence of terpenes and oxygenated compounds, which are well known for their antioxidant properties. Furthermore, the research emphasized the significance of thermogravimetric analysis in evaluating the thermal stability of additives, identifying critical temperatures at which AFP begins to protect biodiesel against oxidation (247.18°C) and the point at which its effectiveness may diminish (469.19°C). The EBP met quality standards regarding acidity, water content and density, but exhibited slightly lower oxidative stability compared with established standards. The correlation between the thermal degradation of biodiesel and the induction period highlighted the efficacy of AFP in mitigating thermal degradation. Nevertheless, it also indicated that maintaining biodiesel quality requires complementary approaches to minimize degradation over time.
Expression levels of tam receptors and ligands in the testes of rats exposed to short and middle‐term 2100 MHz radiofrequency radiation
Authors: Katirci Ertan , Kirimlioglu Esma , Oflamaz Asli O. , Hidisoglu Enis , Cernomorcenco Alexandra , Yargıcoğlu Piraye , Ozen Sukru , Demir Necdet 
Published: May 2024

AbstractWith advances in technology, the emission of radiofrequency radiation (RFR) into the environment, particularly from mobile devices, has become a growing concern. Tyro 3, Axl, and Mer (TAM) receptors and their ligands are essential for spermatogenesis and testosterone production. RFR has been shown to induce testicular cell apoptosis by causing inflammation and disrupting homeostasis. This study aimed to investigate the role of TAM receptors and ligands in the maintenance of homeostasis and elimination of apoptotic cells in the testes (weeks), short‐term sham exposure (sham/1 week), and middle‐term sham exposure (sham/10 weeks). Testicular morphology was assessed using hematoxylin‐eosin staining, while immunohistochemical staining was performed to assess expression levels of TAM receptors and ligands in the testes of all groups. The results showed that testicular morphology was normal in the control, sham/1 week, and sham/10 weeks groups. However, abnormal processes of spermatogenesis and seminiferous tubule morphology were observed in RFR exposure groups. Cleaved Caspase 3 immunoreactivity showed statistically significant difference in 1 and 10 weeks exposure groups compared to control group. Moreover, there was no significant difference in the immunoreactivity of Tyro 3, Axl, Mer, Gas 6, and Pros 1 between groups. Moreover, Tyro 3 expression in Sertoli cells was statistically significantly increased in RFR exposure groups compared to the control. Taken together, the results suggest that RFR exposure negatively affects TAM signalling, preventing the clearance of apoptotic cells, and this process may lead to infection and inflammation. As a result, rat testicular morphology and function may be impaired.
Anatomical study of the relationship between the lumbar intervertebral disc, nerves, and psoas major
Authors: Sun Hongqi , Fan Chaohui , Zhou Xinying , Zheng Zhiyang , Liu Zezheng , Li Qingchu , Zhao Qinghao 
Published: May 2024

AbstractCadaveric study; To describe the characteristics of the nerve and its relationship with the lumbar intervertebral disc and psoas major muscle. Nerve injury is an understudied complication of extreme lateral interbody fusion. A detailed description of the nerve anatomy would be helpful for surgeons to minimize the risk of this complication. The lumbar plexus and lumbar sympathetic nerve of 10 embalmed male cadavers were dissected, and the distribution, number, and spatial orientation of the nerves on the L1/2 to L4/5 intervertebral discs were examined. Metal wires were applied along nerve paths through the psoas major muscle. The position of the nerves was examined on CT. In zone III at L1/2 and L4/5, no nerves were found. In zone II and zone III at L2/3, no lumbar plexus was found, and only the ramus communicans passed through. At the L1‐L5 level, the density of nerves in the posterior half of the psoas major muscle was greater than that in the anterior half. The lumbar plexus was found in all of zone IV. The genitofemoral nerve emerges superficially and anteriorly from the medial border of the psoas major at the L3–4 level, but at the L1/2 level, the sympathetic trunk is located in zone II. The remaining disc‐level sympathetic trunks appear in zone I. No nerves were found in zone III of the L1/2 or L4/5 disc. In zones II and III of L2/3, the lumbar plexus appears safe. The genitofemoral nerve travels through zones II and III of L3/4. The distribution density of nerves in the posterior half of the psoas major muscle was greater than that in the anterior half of that muscle at the L1‐L5 level.
Predicting wheat flour quality for making Japanese sponge cake using flour pasting properties as measured by the Rapid Visco Analyzer
Authors: Mense Andrew L. , Ross Andrew S. , Bock Jayne E. 
Published: May 2024

AbstractBackground and ObjectivesThe objective of this study was to evaluate a series of Rapid Visco Analyzer (RVA) methods for their ability to produce results that were predictive of Japanese sponge cake (JSC) quality. Two solvents (water and 50% [w/w] sucrose in water) and two temperature profiles [Standard 1 (STD 1) and an internal cake temperature profile] were selected to run across a diverse set of flour samples from two crop years that possessed variable bake performance. The results were analyzed for predictive outcomes for JSC prepared using a mechanical fold method.FindingsThe solvent retention capacity (SRC) results did not show any significant trends with JSC quality. The RVA results from both profiles using water as the solvent did not show a significant correlation with JSC quality while the 50% (w/w) sucrose solvent was significantly correlated (p ≤ .01). The STD 1 and internal cake temperature profile batter pasting viscosity (BPV) using the sucrose solvent showed significant (p ≤ .01) correlations with mechanical folded JSC volume (r = .97), firmness (r = −.88), and overall score (r = .85).ConclusionsThe RVA BPV results showed that a 50% sucrose solvent could more accurately be used to predict and screen for JSC quality outcomes. Both RVA profiles could be used with a sucrose solvent to predict JSC quality. JSC volume and overall score showed significant positive correlations with BPV while firmness had a significant negative correlation.Significance and NoveltyThis research identified two RVA profiles that when paired with a 50% (w/w) sucrose solvent could be used to screen for JSC quality using less flour and taking less time than a bake test. This test could potentially assist breeders and millers in quicky screening flours for efficient decision making. This is the first time an RVA temperature profile that mimics the internal rise in temperature for a JSC during baking has been used to predict JSC quality. In addition, the STD 1 profile using the 50% (w/w) sucrose solvent has not been previously used to predict JSC quality.
Enzymatic Production of Glycerol from Glycolaldehyde and Formaldehyde
Authors: Seo Pil‐Won , Kim Ji‐Won , Kim Jeong‐Sun 
Published: May 2024

AbstractGlycerol is a simple and important polyol in both biological and industrial field. To produce glycerol in an eco‐friendly manner, we established a one‐pot cascade reaction by fructose‐6‐phosphate aldolase (FSA) and aldehyde reductase (ALR) from formaldehyde (FALD) and its dimerized form glycolaldehyde (GALD) via L‐glyceraldehyde. For this, we characterized two FSAs at various conditions. Among them, FSA from Gilliamella apicola (GaFSA) has shown the higher L‐glyceraldehyde production activity in the phosphate buffer than the well‐known FSA from Escherichia coli (EcFSA) by more than 2 times. We also characterized two ALRs (xylose reductase from Candida tenuis; CtXR, the annotated DL‐glyceraldehyde reductase from Hypocrea jecorina; HjGLD) that specifically reduce L‐glyceraldehyde into glycerol. Bioproduction of glycerol from FALD and GALD was performed using GaFSA and CtXR, which produced ~8.8 mM glycerol from 25 mM of FALD and GALD (conversion yield of ~35 %). This suggested that a simple process would help in designing a green production of glycerol from a wasteful one‐carbon chemicals.
Dimensionality reducing Gaussian mixture‐based reconstruction for fault detection in multimode processes
Authors: Cui Yanfeng , Fan Wei , Zhou Yongzan 
Published: May 2024

AbstractModern industrial processes increasingly prioritize demands for safety and reliability, spurring substantial research on process monitoring models. Among existing research subjects, concurrent multimode operating conditions are vital for effective process monitoring. This work proposes an efficient dimensionality‐reducing Gaussian mixture‐based reconstruction approach for multimode industrial process monitoring. The t‐SNE method is first employed to transform high‐dimensional data into a lower‐dimensional space that retains critical operational information. Using these reduced dimensions, a robust Gaussian mixture model is established to partition the operation data into different modes. Furthermore, the original data are assigned to the corresponding operating modes, and local variational autoencoder (VAE) reconstruction models are established, respectively. For each VAE model, two statistics are designed, termed and , to detect abnormalities. The proposed method is applied to a three‐phase flow facility, and the superiority over the comparison methods is proved.