bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Musculoskeletal Pain on Sexuality of Male Adolescents and Adults with Juvenile Idiopathic Arthritis
Authors: de AVILA LIMA SOUZA LILIAN , GALLINARO ANDREA LOPES , ABDO CARMITA HELENA NAJJAR , KOWALSKI SÉRGIO CANDIDO , SUEHIRO RICARDO MAISSE , da SILVA CLÓVIS ARTUR ALMEIDA , GOLDENSTEIN-SCHAINBERG CLÁUDIA 
Published: May 2009

Objective.To develop a questionnaire for the evaluation of sexuality of male patients with juvenile idiopathic arthritis (JIA).Methods.A cohort of male patients with rheumatoid factor (RF)-negative polyarticular JIA according to the 2004 revised ILAR criteria and inactive disease was studied. The Health Assessment Questionnaire (HAQ) was applied to all patients. As a control group, 120 age-matched males of the same socioeconomic status were evaluated. A self-administered structured instrument, the Male Sexual Evaluation Questionnaire (MSEQ), was developed by multiprofessional experts to assess sexual life, including satisfaction, practice, and related functional aspects.Results.Thirty-two male patients with RF-negative polyarticular JIA [mean age 20.8 ± 3.8 yrs (range 16–26), mean disease duration 15.4 ± 3.6 yrs (range 13–20)] were studied. Mean HAQ score was 1.25 ± 0.67 (range 0.1–2.1). Masturbation was practiced similarly by patients and controls (87.5% vs 91%; p > 0.999), although joint pain was observed in only 2 (7%) patients. Regular sexual intercourse (≥ once/week) was reported by 78% of patients and 62% of controls (p = 0.86). Joint pain during intercourse was more frequent in patients (48% vs 3% in controls; p < 0.001). The mean HAQ score was higher in the 12 patients with joint pain (hips = 3, knees = 5, and hips + knees = 4) during intercourse compared to the 13 patients without joint pain (1.82 ± 0.27 vs 1.43 ± 0.32; p < 0.05). Preserved desire and satisfaction were universal findings for all JIA patients and controls.Conclusion.The MSEQ was applicable to this cohort of male patients with RF-negative polyarticular JIA and showed that sexual life is preserved despite longterm disease, morbidity/functional dysfunction, and joint pain.
Efficacy, Safety, and Tolerability of the Cyclooxygenase-Inhibiting Nitric Oxide Donator Naproxcinod in Treating Osteoarthritis of the Hip or Knee
Authors: KARLSSON JON , PIVODIC ALDINA , AGUIRRE DIANA , SCHNITZER THOMAS J. 
Published: May 2009

Objective.Naproxcinod, a cyclooxygenase-inhibiting nitric oxide donator antiinflammatory drug, was evaluated in this phase 2, double-blind, randomized, parallel group study to determine its optimal dose in patients with osteoarthritis (OA).Methods.In total 543 patients with OA of the hip or knee were randomized to receive naproxcinod 750 mg once daily (qd), 750 mg twice daily (bid), 1125 mg bid, rofecoxib 25 mg qd, or placebo for 6 weeks. The primary efficacy variable was the within-patient change from baseline to the average of Weeks 4 and 6 in WOMAC™ pain subscale score. Treatment-group differences were compared using ANCOVA with factors for treatment and country, and baseline pain subscale score as a covariate. Safety endpoints included vital signs and adverse events. Treatment-group differences in mean change from baseline to Week 6 in systolic blood pressure (SBP) were compared using an ANCOVA with treatment and country as fixed factors and baseline SBP as covariate.Results.All active treatments showed statistically significant reductions in WOMAC pain score compared to placebo (p ≤ 0.02). Naproxcinod was well tolerated. The 750 mg bid dose appeared to have the best balance of benefit versus safety. All 3 naproxcinod doses showed a reduction in SBP, while an increase was shown for rofecoxib. The changes for the naproxcinod groups were statistically significantly better compared to rofecoxib (p ≤ 0.02).Conclusion.This dose-finding study identified naproxcinod 750 mg bid as the upper dose for further therapeutic confirmatory clinical trials. Naproxcinod at all doses decreased mean SBP compared to an increase with rofecoxib.
MRI for breast cancer: Current indications
Authors: Ojeda-Fournier Haydee , Comstock Christopher E 
Published: May 2009

AbstractMammography is the only imaging study that has been proven in multiple large randomized trials to decrease breast cancer mortality. Mammography, however, has its limitations and, as such, other modalities that can complement it are being studied. One of these is dynamic contrast-enhanced breast MRI, which has emerged as an important adjunctive modality and is at present the most sensitive modality that we have to evaluate the breast. The American College of Radiology, in its 2004 practice guidelines, has outlined the 12 current indications for breast MRI. This manuscript reviews and provides examples of each of these.
Pictorial review of MRI/CT Scan in congenital temporal bone anomalies, in patients for cochlear implant
Authors: Gupta Santosh S , Maheshwari Shailendra R , Kirtane Milind V , Shrivastav Nitin 
Published: May 2009

AbstractHigh-resolution CT scan (HRCT) and MRI are routinely performed prior to cochlear implant surgery. These modalities help assess the status of the inner ear structures. A few patients have significant anomalies, which need to be assessed and understood in detail. We present a pictorial essay of these anomalies and described our HRCT and MRI techniques in patients being imaged prior to surgery.
Pictorial essay: B-scan ultrasonography in ocular abnormalities
Authors: Aironi VD , Gandage SG 
Published: May 2009

AbstractB-scan ultrasonography (USG) is a simple, noninvasive tool for diagnosing lesions of the posterior segment of the eyeball. Common conditions such as cataract, vitreous degeneration, retinal detachment, ocular trauma, choroidal melanoma, and retinoblastoma can be accurately evaluated with this modality. B-scan USG is cost-effective, which is an important consideration in the rural setting. In addition, it is noninvasive and easily available and the results are reproducible.
Papillary carcinoma arising from a thyroglossal duct cyst
Authors: Smiti S , Mahmood Nabil Sherif 
Published: May 2009

AbstractThis report describes a case of papillary carcinoma arising from a thyroglossal duct cyst (TDC) in a young woman. Imaging showed a heterogeneous cystic lesion at the level of the hyoid, with calcifications and enhancing septae. We compared the USG, CT scan, and MRI findings with those reported previously in literature and we conclude that the presence of a midline cystic lesion with calcification in a young adult should arouse suspicion of papillary carcinoma in a TDC.
Dynamic MRI of the vocal cords using phased-array coils: A feasibility study
Authors: Schlamann Marc , Lehnerdt Götz , Maderwald Stefan , Ladd Susanne 
Published: May 2009

Abstract
Objective: Endoscopy for evaluation of hoarseness is an invasive procedure and the result depends, to a large extent, on the patient′s cooperation. Successful laryngoscopy can also be hampered by unfavourable anatomic conditions, a severely impaired general condition, or severe coagulopathy. We evaluated the feasibility of doing ultra-fast magnetic resonance imaging (MRI), using a recent dedicated coil design and a sequence with inherently high signal-to-noise ratios (SNR), for the detection of motility disorders of the vocal cords. Materials and Methods: Twelve consecutive patients (eight males and four females) in the age range of 24-80 years (mean age 60 years) with persistent hoarseness and presumed vocal cord palsy were included in this blinded prospective study. Two two-element phased-array carotid coils were used for signal reception. The first coronal real-time steady-state free precession (SSFP) sequence was performed during silence (i.e., with no vocal cord motion) and the second while phonating ′heee.′ Qualitative MRI findings were compared with the results of the endoscopic examination. Results: The examination time for setup, patient instruction and positioning, localization scans, and real-time SSFP scans was less than 10 min. Seven patients with laryngoscopically-confirmed unilateral palsy of the vocal cord were correctly identified with MRI. The five remaining patients had hoarseness due to causes other than vocal cord palsy; they showed normal motion of the vocal cords on MRI and endoscopy. Conclusion: Compared to preceding studies, the image quality in this study is supported by excellent SNR (carotid phased-array coils and SSFP sequence with higher SNR if compared to a spoiled gradient-echo sequence or an EPI sequence). Further studies, with larger groups of patients, are necessary to show if this protocol can serve as an alternative to endoscopy in selected cases.
Extraosseous Ewing′s sarcoma / primitive neuroectodermal tumor of the sacral nerve plexus
Authors: Narula MK , Gupta Nishant , Anand Rama , Kapoor Sudhir 
Published: May 2009

AbstractWe report an unusual case of Ewing′s sarcoma / primitive neuroectodermal tumor (PNET) of the sacral nerve plexus in a 9-year-old boy who presented with a soft tissue swelling and severe piercing pain in the lower back region. MRI of the lumbosacral spine showed a lobulated soft tissue mass with clubbed finger-like projections along the path of the sacral nerves, which had caused widening of the spinal canal and the sacral foramina (S2-S4 level). There was presacral extension and posterior scalloping of the sacral vertebrae. Histopathology of the lesion confirmed Ewing′s sarcoma / PNET of the sacral spinal nerve plexus. The patient responded favorably to chemotherapy and radiotherapy, showing clinical and radiological improvement.
Novel lineup methods for improving the performance of older eyewitnesses
Authors: Wilcock Rachel , Bull Ray 
Published: May 2009

AbstractPrevious research shows that older witnesses demonstrate poorer lineup performance compared to younger adults. Two experiments are presented which investigated the effectiveness of pre‐identification procedures aimed to reduce false identifications made by older adults. In experiment one older adults' demonstrated poorer lineup performance compared to younger adults. However, older adults benefited from pre‐lineup questions and a practice lineup prior to viewing a target absent (TA) lineup. In a second experiment, participants in the practice lineup condition made significantly fewer false identifications and more correct rejections on two TA lineups compared to participants in the control condition. On both target present (TP) lineups there was no significant difference in lineup performance between the two conditions. The effect of pre‐identification procedure on self‐reported lineup decision strategy and memory for non‐biased lineup instructions are discussed, as well as future research directions. Copyright © 2009 John Wiley & Sons, Ltd.
Stereochemical Control by an Ester Group or Olefin Ligand in Platinum‐Catalyzed Carboalkoxylation of 6‐(1‐Alkoxyethoxy)‐ hex‐2‐ynoates
Authors: Nakamura Itaru , Chan Ching Siew , Araki Toshiharu , Terada Masahiro , Yamamoto Yoshinori 
Published: May 2009

Abstractmagnified imageThe cyclization of 6‐(1‐alkoxyethoxy)hex‐2‐ynoantes in the presence of the platinum‐olefin catalyst system gave the corresponding multisubstituted 2‐[dihydrofuran‐2(3H)‐ylidene]acetates in good to high yields. The Z/E selectivity is controlled by the electronic property of the ester group; the 2,2,2‐trichloroethyl ester yielded the Z isomer, while the phenyl ester gave the E isomer. Moreover, we found that the Z/E selectivities in the reaction of phenyl esters 1h, 1n, and 1o were controlled by the olefin ligand. For example, the platinum‐catalyzed reaction of 1h using 1,5‐hexadiene as the olefin ligand gave E‐2h as the major product, while that using 1,5‐cyclooctadiene produced mainly the Z isomer.
Congruence of individual cranial bone morphology and neutral molecular affinity patterns in modern humans
Authors: von Cramon‐Taubadel Noreen 
Published: May 2009

AbstractRecent studies have demonstrated that the shape of the human temporal bone is particularly strongly correlated with neutral genetic expectation, when compared against other cranial regions, such as the vault, face, and basicranium. In turn, this has led to suggestions that the temporal bone is particularly reliable in analyses of primate phylogeny and human population history. While several reasons have been suggested to explain the temporal bone's strong fit with neutral expectation, the temporal bone has never systematically been compared against other individual cranial bones defined using the same biological criteria. Therefore, it is currently unknown whether the shapes of all cranial bones possess reliable information regarding neutral genetic evolution, or whether the temporal bone is unique in this respect. This study tests the hypothesis that the human temporal bone is more congruent with neutral expectation than six other individual cranial bones by correlating population affinity matrices generated using neutral genetic and 3D craniometric data. The results demonstrate that while the temporal bone shows the absolute strongest correlation with neutral genetic data compared with all other bones, it is not statistically differentiated from the sphenoid, frontal, and parietal bones in this regard. Potential reasons for the temporal bone's consistently strong fit with neutral expectation, such as its overall anatomical complexity and/or its contribution to the architecture of the basicranium, are examined. The results suggest that future phylogenetic and taxonomic studies would benefit from considering the shape of the entire cranium minus those regions that deviate most from neutrality. Am J Phys Anthropol, 2009. © 2009 Wiley‐Liss, Inc.
Eagle's syndrome: A review of the literature
Authors: Piagkou Maria , Anagnostopoulou Sophia , Kouladouros Konstantinos , Piagkos Giannoulis 
Published: May 2009

AbstractEagle's syndrome represents symptoms brought on by compression of regional structures by elongation of the styloid process or ossification of the stylohyoid or stylomandibular ligaments. Watt Eagle described it for the first time in 1937, dividing it into two subtypes: the “classic syndrome” and the “stylo‐carotid artery syndrome.” Many theories have been put forth regarding its pathogenesis. Depending on the underlying pathogenetic mechanism and the anatomical structures compressed or irritated by the styloid process, symptoms vary greatly, ranging from cervicofacial pain to cerebral ischemia. The syndrome generally follows tonsillectomy or trauma. Diagnosis is confirmed by radiological findings. Palpation of the styloid process in the tonsillar fossa and infiltration with anesthesia are also used in making the diagnosis. The treatment is primarily surgical; however, some conservative treatments have also been used. The current literature on Eagle's syndrome is reviewed, highlighting its often underestimated frequency and its clinical importance. Clin. Anat. 22:545–558, 2009. © 2009 Wiley‐Liss, Inc.
Symmetric deformation of 3D face scans using facial features and curvatures
Authors: Kim Jeong‐Sik , Choi Soo‐Mi 
Published: May 2009

AbstractFacial symmetry is one of the number of aesthetic traits associated with health, physical attractiveness and beauty of a person. In this paper, we present a novel method for enhancing the symmetry of a scanned 3D face automatically. To handle detailed areas of the face, we developed a new local 3D shape descriptor based on facial features and surface curvatures. Our shape descriptor can improve the accuracy when deforming a 3D face towards a symmetric configuration, because it provides accurate point pairing with respect to the plane of symmetry. It can also reduce the computational complexity by dividing the given face into partitioned slices and facial feature regions. In addition, we use point‐based representation over all stages of symmetrization without generating a consistent triangle mesh or texture parameterization, which makes it much easier to support discrete processes such as symmetric deformation and to be combined with more sophisticated manipulations later such as cutting of surfaces. Finally, we performed a statistical analysis to assess subjects' preference for the symmetrized faces by our approach. Copyright © 2009 John Wiley & Sons, Ltd.
Facile Synthesis of Enantiomerically Pure 2‐ and 2,3‐Disubstituted Furans Catalysed by Mixed Lewis Acids: An Easy Route to 3‐Iodofurans and 3‐(Hydroxymethyl)furans
Authors: Saquib Mohammad , Husain Irfan , Kumar Brijesh , Shaw Arun K. 
Published: May 2009

AbstractEnantiopure furan synthesis: A synthesis, catalysed by mixed Lewis acids (ZrCl4/ZnI2), of enantiomerically pure 2‐ and 2,3‐disubstituted furan derivatives, including 3‐iodofuran and 3‐ (hydroxymethyl)furan derivatives, in good to very good yields from commercially available 3,4,6‐tri‐O‐acetyl‐D‐glucal is described. Key features of this method are the use of inexpensive reagents in catalytic amounts, mild reaction conditions and an easy workup procedure.magnified imageSimple and efficient syntheses, catalysed by a mixed Lewis acid system (ZrCl4/ZnI2), of enantiomerically pure 2‐ and 2,3‐disubstituted furan derivatives—including important synthons such as 3‐iodofuran and 3‐(hydroxymethyl)furan derivatives—from commercially available 3,4,6‐tri‐O‐acetyl‐D‐glucal are described. The transformation is achieved through a synergistic interaction between ZrCl4 and ZnI2 in catalytic amounts.
Efficient Preparation of Separable Pseudo[n]rotaxanes by Selective Threading of Oligoalkylammonium Salts with Cucurbit[7]uril
Authors: Yin Jun , Chi Chunyan , Wu Jishan 
Published: May 2009

AbstractA salty solution: Well‐defined pseudo[n]rotaxanes (n=2, 3, 4, 5) were prepared as pure compounds through threading of oligoalkylammonium salts with cucurbit[7]uril (CB[7]) and by subsequent counterion exchange. A unique self‐assembling mode was observed (see graphic).magnified imageWe describe the efficient preparation of well‐defined, homogeneous pseudo[n]rotaxanes (n=2, 3, 4, 5) by the selective threading of oligoalkylammonium salts with cucurbit[7]uril (CB[7]) and the subsequent simple separation of the pure pseudo[n]rotaxanes from the complicated system. A series of well‐defined oligoalkylammonium salts were prepared by stepwise synthesis and their molecular recognition and self‐assembly with a solution of CB[7] in CF3CO2D/D2O (1:1 v/v) were investigated. As a result of the high affinity of CB[7] to the p‐xylene diammonium units (‐NH2+CH2C6H4CH2NH2+‐) in the oligoalkylammonium salts, the CB[7] rings threaded onto these cationic threads to form pseudorotaxane structures. Interestingly, due to the repulsive dipole–dipole electrostatic interactions between the CB[7] units and steric hindrance, the threading process exhibited a high selectivity and a unique self‐assembling mode was discovered in which two CB[7] units cannot bind the same ammonium site. The as‐formed well‐defined pseudo[n]rotaxanes can be easily separated as pure compounds from the mixture by simple counterion exchange with NH4PF6 and the pure pseudo[n]rotaxanes are stable and partially soluble in normal organic solvents. Such facile preparation and separation are mainly ascribed to the high binding constant between CB[7] and the oligoalkylammonium salts and the unique solubility of CB[7] in protonic acid. As most pseudorotaxanes reported in the literature exist as a dynamic mixture and their separation is usually difficult, our research represents one good example in which pure pseudo[n]rotaxanes (n=2, 3, 4, 5) can be obtained by a simple “threading‐followed‐by‐precipitation” method.
Diels–Alder “Click” Chemistry in Designing Dendritic Macromolecules
Authors: Franc Grégory , Kakkar Ashok K. 
Published: May 2009

AbstractSimple, versatile and green: Diels–Alder “click” chemistry is a simple, versatile and “greener” approach in the design of a diverse range of dendritic macromolecules (see scheme).magnified imageIn the current decade, design of dendritic macromolecules including dendrimers and polymers has reached a new era, mainly due to the remarkably successful and elegant synthetic routes that have been developed recently. This survey aims at demonstrating the potential of the Diels–Alder “click” chemistry, a very effective, simple and versatile synthetic tool in the formation of complex and functional nanometer‐sized assemblies. The role of retro Diels‐Alder reaction is also explored to highlight the increasing competitive potential of this strategy in the design of dendritic macromolecules of topical interest. The potential “green” nature of this methodology in constructing macromolecular assemblies is also evaluated.
Alternative splicing, phylogenetic analysis, and craniofacial expression of zebrafishtbx22
Authors: Jezewski P. A. , Fang P.‐K. , Payne‐Ferreira T. L. , Yelick P. C. 
Published: May 2009

AbstractMutations in human TBX22 cause X‐linked cleft palate with ankyloglossia syndrome (CPX; OMIM 303400). Since the secondary palate was an adaptation to breathing on land, we characterized zebrafishtbx22to study molecular mechanisms regulating early vertebrate craniofacial patterning. Rapid Amplification of cDNA Ends (RACE) analyses revealed two zebrafishtbx22splice isoforms,tbx22‐1andtbx22‐2, encoding proteins of 444 and 400 amino acids, respectively.tbx22‐1resembles canonical Tbx22 orthologs, whiletbx22‐2lacks conserved N‐terminal sequence. Developmental RT‐PCR revealed thattbx22‐1is maternally and zygotically expressed, whiletbx22‐2is expressed zygotically. WISH analyses revealed strongtbx22mRNA expression in ectomesenchyme underlying the stomodeum, a bilaminar epithelial structure demarcating early mouth formation, and in early presumptive jaw joints. Zebrafishtbx22expression mirrored some aspects of mammalian Tbx22, consistent with roles in early vertebrate face patterning. These studies identify an early transcription factor governing vertebrate facial development, which may underlie common craniofacial birth disorders. Developmental Dynamics 238:1605–1612, 2009. © 2009 Wiley‐Liss, Inc.
Experimental study on water spray suppression on burning upholstered chair in an enclosure with different application times
Authors: Xie Q. Y. , Zhang L. , Zhang H. P. 
Published: May 2009

AbstractThe objective of this work is to investigate the effects of the application time of water spray on the burning upholstered chair in an enclosure. A series of experiments are conducted with the same water flow rate in an ISO 9705 fire test room in which a water spray system is installed. Several identical upholstered chairs are used in the experiments with the application times 20, 25, 30, 40 and 45 s after the ignition of upholstered chair, respectively. The results show that there is nearly an exponential relationship between the peak heat release rates and the relative application times of water spray. It is also shown that there is a polynomial relationship between the relative time for the peak heat release rate and the relative application time of water spray. However, there is an exponential relationship between the whole relative extinguishing time and the relative application time of water spray. A sudden increase is detected before the decreasing of CO generation rates after the water spray is applied on the burning upholstered chair. The average temperatures of the upper hot smoke layer under the ceiling will generally be lower with the earlier application of water spray. Copyright © 2009 John Wiley & Sons, Ltd.
A new catalytic method for ecofriendly synthesis of bis‐ and trisindolylmethanes by zirconyldodecylsulfate under mild conditions
Authors: Jafarpour Maasoumeh , Rezaeifard Abdolreza , Golshani Tayebeh 
Published: May 2009

Abstract
magnified imageZirconyldodecylsulfate (ZrO(DS)2) as a versatile Lewis acid‐surfactant‐combined (LASC) catalyzed ecofriendly synthesis of bis‐ and tris(indolyl)methanes via electrophilic substitution of indoles with carbonyl compounds in high yields at mild conditions. J. Heterocyclic Chem., (2009).