bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dielectric Properties of a Printed Sol–Gel Matrix Composite
Authors: Lehnert Tobias , Herbeck‐Engel Petra , Adam Jens , Klein Gabi , Kololuoma Terho , Veith Michael 
Published: May 2010

AbstractLow temperature processable materials with high dielectric constants are required for application on flexible organic substrates, for example, in printed electronics. To date, mainly organic polymers with embedded functional particles have been investigated for this purpose. For the first time, we present a printable dielectric composite material composed of ferroelectric high permittivity particles (BaTiO3) bonded by a mainly inorganic sol–gel derived network. The exemplary optimization of the properties by varying the sol–gel precursor illustrates the potential of sol–gel chemistry for printable functional materials. An operational gravure printed capacitor including printed silver electrodes is presented. The measured dielectric constants are among the highest reported in literature for low temperature cured films with moderate dissipation factors. Besides these promising dielectric properties, this composite film shows a ferroelectric response.
Silver Nanoparticles with Controlled Dispersity and Their Assembly into Superstructures
Authors: Moh Karsten , Werner Ulf , Koch Marcus , Veith Michael 
Published: May 2010

AbstractIn this paper we report on the influence of particle size distribution, particle substrate interaction, and drying behavior on the self‐assembly process using ligand stabilized silver particles. Two‐dimensional particle arrays were characterized using transmission electron microscopy and extensive image analysis. The formation of such structures was observed in situ using an environmental scanning electron microscope in WET‐STEM mode. The results confirm that a small particle size distribution is crucial for the formation of regular particle patterns with long range order, but also the particle substrate interaction and the particle density have an influence on the degree of ordering. Additionally, we find that separated binary particle assemblies keep the orientation of their two‐dimensional hexagonal lattices over alternating domains of small and big particles. This is probably enabled due to the formation of dislocations and a small change of the course of the lattice lines within the respective boundary.
High Quality Factor Metallodielectric Hybrid Plasmonic–Photonic Crystals
Authors: Yu Xindi , Shi Lei , Han Dezhuan , Zi Jian , Braun Paul V. 
Published: May 2010

AbstractA 2D polystyrene colloidal crystal self‐assembled on a flat gold surface supports multiple photonic and plasmonic propagating resonance modes. For both classes of modes, the quality factors can exceed 100, higher than the quality factor of surface plasmons (SP) at a polymer–gold interface. The spatial energy distribution of those resonance modes are carefully studied by measuring the optical response of the hybrid plasmonic–photonic crystal after coating with dielectric materials under different coating profiles. Computer simulations with results closely matching those of experiments provide a clear picture of the field distribution of each resonance mode. For the SP modes, there is strong confinement of electromagnetic energy near the metal surface, while for optical modes, the field is confined inside the spherical particles, far away from the metal. Coating of dielectric material on the crystal results in a large shift in optical features. A surface sensor based on the hybrid plasmonic–photonic crystal is proposed, and it is shown to have atomic layer sensitivity. An example of ethanol vapor sensing based on physisorption of ethanol onto the sensor surface is demonstrated.
Fourth case of cerebral, ocular, dental, auricular, skeletal syndrome (CODAS), description of new features and molecular analysis
Authors: Marlin S. , Ducou Le Pointe H. , Le Merrer M. , Portnoi M.F. , Chantot S. , Jonard L. , Mantel‐Guiochon A. , Siffroi J.P. , Garabedian E.N. , Denoyelle F. 
Published: May 2010

AbstractCerebral, ocular, dental, auricular, skeletal syndrome (CODAS, OMIM 600373) is a very rare congenital malformation syndrome. This clinical entity is highly distinctive and associates mental retardation, cataract, enamel abnormalities, malformations of the helix, epiphyseal and vertebral malformations, and characteristic dysmorphic features. Since 1991, only three affected children have been reported. The etiology and pattern of inheritance of CODAS syndrome still remain unknown. We describe a new sporadic case presenting with all the characteristic features of CODAS syndrome associated with previously unreported malformations of the heart, larynx, and liver. All investigations such as karyotype, metabolic screening and array CGH were normal. © 2010 Wiley‐Liss, Inc.
Clinical variability and novel neurodevelopmental findings in 49, XXXXY syndrome
Authors: Gropman Andrea L. , Rogol Alan , Fennoy Ilene , Sadeghin Teresa , Sinn Stephanie , Jameson Robert , Mitchell Francine , Clabaugh Jaye , Lutz‐Armstrong Margaret , Samango‐Sprouse Carole A. 
Published: May 2010

Abstract49, XXXXY is a rare chromosomal syndrome due to double nondisjunction of the replicating X chromosome. Considered a severe variant of XXY or Klinefelter syndrome, boys with this chromosome constitution are assumed to have severe mental retardation (MR) in addition to craniofacial, genital, endocrine, and heart abnormalities. Here, we present a multidisciplinary analysis including the clinical and neurobehavioral aspects of this condition in 20 boys with 49, XXXXY who share a common phenotype and neurobehavioral profile. The phenotypic presentation of the boys with 49, XXXXY shares some characteristics with 47, XXY, but there are also other unique and distinctive features. Previously unappreciated intact nonverbal skills are evident in conjunction with moderate to severe developmental dyspraxia. Variability in clinical and cognitive functioning may reflect skewed X inactivation, mosaicism, or other factors that warrant further investigation. © 2010 Wiley‐Liss, Inc.
Facioaudiosymphalangism syndrome and growth acceleration associated with a heterozygous NOG mutation
Authors: Rudnik‐Schöneborn Sabine , Takahashi Tsutomu , Busse Sabine , Schmidt Thorsten , Senderek Jan , Eggermann Thomas , Zerres Klaus 
Published: May 2010

AbstractWe report on a father and son with facioaudiosymphalangism syndrome, an alternative designation for multiple synostoses syndrome, type I. This syndrome includes synostosis, brachydactyly, craniofacial dysmorphic features, stapes fixation, hyperopia, and growth retardation. In contrast to the typical presentation, the height of the 10‐year‐old son was above the 97th centile from the age of 3.5 years and he had markers of an activated bone metabolism. The father and son had a novel heterozygous missense mutation c.696C > G, p.Cys232Trp, in the NOG gene. While not yet described in human NOG‐related disorders, there is experimental evidence that suppression of noggin might accelerate osteogenesis, which could explain the phenotype in the family reported here. © 2010 Wiley‐Liss, Inc.
Kabuki syndrome and cancer in two patients
Authors: Tumino Manuela , Licciardello Maria , Sorge Giovanni , Cutrupi Maria Concetta , Di Benedetto Fabrizio , Amoroso Loredana , Catania Roberta , Pennisi Monica , D'Amico Salvatore , Di Cataldo Andrea 
Published: May 2010

AbstractBoth hepatoblastoma and neuroblastoma are occasionally associated with congenital syndromes such as Beckwith–Wiedemann syndrome and trisomy 18. There have been no reports of hepatoblastoma in patients with Kabuki syndrome, whereas one patient with neuroblastoma and this syndrome has been reported. In this paper we present two patients with Kabuki syndrome and a neoplasm: a child of 6 years with hepatoblastoma and an infant, of 6 months affected by neuroblastoma. © 2010 Wiley‐Liss, Inc.
Spondylo‐epiphyseal dysplasia, Maroteaux type (pseudo‐Morquio syndrome type 2), and parastremmatic dysplasia are caused by TRPV4 mutations
Authors: Nishimura Gen , Dai Jin , Lausch Ekkehart , Unger Sheila , Megarbané André , Kitoh Hiroshi , Kim Ok Hwa , Cho Tae‐Joon , Bedeschi Francesca , Benedicenti Francesco , Mendoza‐Londono Roberto , Silengo Margherita , Schmidt‐Rimpler Maren , Spranger Jurgen , Zabel Bernhard , Ikegawa Shiro , Superti‐Furga Andrea 
Published: May 2010

AbstractRecent discoveries have established the existence of a family of skeletal dysplasias caused by dominant mutations in TRPV4. This family comprises, in order of increasing severity, dominant brachyolmia, spondylo‐metaphyseal dysplasia Kozlowski type, and metatropic dysplasia. We tested the hypothesis that a further condition, Spondylo‐epiphyseal dysplasia (SED), Maroteaux type (MIM 184095; also known as pseudo‐Morquio syndrome type 2), could be caused by TRPV4 mutations. We analyzed six individuals with Maroteaux type SED, including three who had previously been reported. All six patients were found to have heterozygous TRPV4 mutations; three patients had unreported mutations, while three patients had mutations previously described in association with metatropic dysplasia. In addition, we tested one individual with a distinct rare disorder, parastremmatic dysplasia (MIM 168400). This patient had a common, recurrent mutation seen in several patients with Kozlowski type spondylo‐metaphyseal dysplasia. We conclude that SED Maroteaux type and parastremmatic dysplasia are part of the TRPV4 dysplasia family and that TRPV4 mutations show considerable variability in phenotypic expression resulting in distinct clinical‐radiographic phenotypes. © 2010 Wiley‐Liss, Inc.
The phylogenetic affinities of the Pondaung tali
Authors: Dagosto Marian , Marivaux Laurent , Gebo Daniel L. , Beard K. Christopher , Chaimanee Yaowalak , Jaeger Jean‐Jacques , Marandat Bernard , Soe Aung Naing , Kyaw Aung Aung 
Published: May 2010

AbstractThe phylogenetic affinities of the primates of the late middle Eocene Pondaung Formation of Myanmar have long been disputed. The discovery of the NMMP 39 talus (Marivaux et al.: Proc Natl Acad Sci USA 100 (2003) 13173–13178) provided the first clear evidence from the postcranium that a relatively large‐bodied haplorhine primate is represented in the Pondaung fauna. Another talus (NMMP 82; Marivaux et al., 2010). Talar morphology, phylogenetic affinities and locomotor adaptation of a large‐bodied amphipithecid primate from the late middle Eocene of Myanmar, Am J Phys Anthropol DOI: 10.1002/ajpa.21307) has been recently recovered which also pertains to Haplorhini. The metric and nonmetric features supporting the hypothesis of anthropoid affinities for NMMP 39 have been criticized by Gunnell and Ciochon (Gunnell GF, Ciochon RL. 2008. Revisiting primate postcrania from the Pondaung Formation of Myanmar. In: Fleagle JG, Gilbert CC, editors. Elwyn Simons: a search for origins. New York: Springer. p 211–228). Their analysis, however, was based on a very limited choice of variables, taxa, and individuals. Based on an extended sample, we are able to produce both principal components and discriminant functions that yield a rather clear separation of extant haplorhine and strepsirhine tali. Both principal components and discriminant function scores of the Pondaung tali fall with those of haplorhine primates. In addition, the Pondaung tali lack all the derived nonmetric features characteristic of strepsirhine primates, but exhibit all the features characteristic of haplorhine primates. We dispute the features Gunnell and Ciochon (2008) claim are uniquely shared by the Pondaung tali and adapiforms. Their rejection of the phylogenetic significance of the features shared by these tali and haplorhines is unwarranted by the evidence. Based on both metric and nonmetric features, the Pondaung tali are structurally most similar to the tali of haplorhines, particularly anthropoids. Am J Phys Anthropol 143:223–234, 2010. © 2010 Wiley‐Liss, Inc.
Melt spun microporous fibers using poly(lactic acid) and sulfonated copolyester blends for tissue engineering applications
Authors: Sumanasinghe Ruwan D. , Haslauer Carla M. , Pourdeyhimi Behnam , Loboa Elizabeth G. 
Published: May 2010

AbstractMicroporous fibers can potentially increase diffusional properties of three‐dimensional nonwoven scaffolds used for tissue engineering applications. We have investigated the use of a water‐dispersible copolyester, sulfonated copolyester (SP), to create micropores in composite fibers containing a blend of SP and poly(lactic acid) (PLA) at 1, 3, 5, and 10% SP content. PLA and SP were blended at 175°C in a microcompounder followed by extrusion of composite fibers and removal of SP from composite fibers by using hydrodispersion to form micropores in the composite fibers. Differential scanning calorimetric studies on unhydrolysed composite fibers showed that SP was partially miscible in PLA. Fourier transform infrared mapping of composite fiber cross sections revealed that SP was randomly dispersed throughout the cross section where the degree of dispersion depended on the SP content. As revealed by the scanning electron micrographs, the size of the micropores was dependent on the SP content. Micropores on fiber cross sections were observed in fibers above 3% SP indicating that at least 3% SP content is needed to produce droplet morphology of SP in these fibers. These results show that SP can be successfully used in a blend with PLA to produce microporous fibers to fabricate three‐dimensional nonwoven scaffolds for tissue engineering applications. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Preparation of chitosan nanoparticles and their application to Antheraea pernyi silk
Authors: Lu Yan‐Hua , Chen Yu‐Yue , Lin Hong , Wang Cheng , Yang Zhao‐Dan 
Published: May 2010

AbstractIn this study, a chitosan nanoparticle dispersion solution as a novel multifunctional agent was developed to modify Antheraea pernyi silk. An ionization gelation methodology with chitosan and sodium tripolyphosphate (STPP) was used to prepare the chitosan nanoparticle solution, and then, Fourier transform infrared spectra, laser particle size analysis, and transmission electron microscopy (TEM) were used to characterize the structure and size distribution of the chitosan nanoparticles. The peaks at 3390.7, 1633.7, 1538.2, and 1258.1 cm−1 revealed the reaction between the chitosan and STPP molecules in the chitosan nanoparticles. The average size of the nanoparticles in the aqueous dispersion solution was approximately 20 nm. TEM images clearly showed the round spherical morphology and the distribution of the particles in the solid state. The obtained chitosan nanoparticle dispersion solution was then applied to treat silk filaments and fabric. The results indicate that the surface of the chitosan‐nanoparticle‐treated A. pernyi silk fiber was rougher than that of the chitosan‐treated and untreated ones, and a higher specific surface was achieved. In addition, the antibacterial activity, breaking strength, and wrinkle‐resistance properties of the chitosan‐nanoparticle‐treated A. pernyi silk fabric were also enhanced. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
Geophysical Archaeology Research Agendas for the Future: Some Ground‐penetrating Radar Examples
Authors: Conyers Lawrence B. , Leckebusch Juerg 
Published: May 2010

AbstractArchaeological geophysics research and its applications to archaeology are today positioned to move in a number of directions, building on successes in the past few decades. The basics of data acquisition, processing and interpretation are now commonplace, and along with a variety of new geophysical tools and software, readily available to most dedicated practitioners. It is now time to move beyond the basics to develop new areas of research for the coming decades. Here, we propose some future avenues that can be followed, using ground‐penetrating radar (GPR) as an example. One avenue is the application of these techniques to test ideas about culture and history in ways not possible using traditional archaeological methods. Another is the application of sophisticated new equipment and three‐dimensional processing methods that can produce greater precision in the products produced, while simplifying data acquisition and revealing more information about buried archaeological features. While we discuss below our ideas with regard to the future of GPR, these basic concepts and future pathways are potentially applicable to the other commonly used near‐surface geophysical methods. Copyright © 2010 John Wiley & Sons, Ltd.
Affective motivations to help others: A two‐stage model of donation decisions
Authors: Dickert Stephan , Sagara Namika , Slovic Paul 
Published: May 2010

AbstractEmotional reactions are an important element in the motivation to help others. Our research examined the role of affective vs. deliberative information processing in the genesis and use of emotional reactions in decisions to provide financial aid to people in distress. In two studies, we investigated whether information processing mode influenced participants' donations, affective reactions, and the relationship between the two. Information processing was manipulated by a priming procedure and a cognitive load paradigm. Participants' empathic emotions were assessed by self‐reported sympathy, compassion, and distress. Additionally, we measured how much better a donation would make participants feel and their anticipated regret for not donating, which were taken as indicators of their motivation to donate as a form of mood management. Results suggest that different mechanisms govern the initial decision to donate money (Stage 1) compared to later decisions on how much money to donate (Stage 2). Motivations for mood management were primarily predictive of donation decisions, whereas empathic feelings were predictive of the donation amount. The potentially disruptive effects of deliberative processing on prosocial behavior are discussed in light of a two‐stage processing model of donations. Copyright © 2010 John Wiley & Sons, Ltd.
Model Based Quantification of Internal Flow Distributions from Breakthrough Curves of Flat Sheet Membrane Chromatography Modules
Authors: von Lieres E. , Wang J. , Ulbricht M. 
Published: May 2010

AbstractA novel model for quantifying radial flow distributions in flat sheet membrane chromatography modules under non‐binding conditions is presented and applied for the practical analysis of two modules. The proposed model partitions the total void volume of the chromatography module into zones that are considered homogeneous with respect to flow velocity. The corresponding solute concentrations are time variant, but also spatially homogeneous within each zone. The model is mathematically represented and analytically solved as a network of continuously stirred tank reactors (CSTR). An additional plug flow reactor (PFR) is connected in series with the CSTR network in order to account for a time‐lag that is not associated with the system dispersion. The capability of the model to describe experimental breakthrough data is compared to the frequently applied standard model for extra‐membrane system dispersion, which consists of a single CSTR in series with a PFR. Non‐binding conditions are deliberately chosen for studying the impact of module geometries on breakthrough curves separately from chromatographic membrane performance. The commercial CIM module and a custom designed cell (Scell) are studied with acetone and lysozyme as test tracers at varied flow rates and for various membrane pore sizes under non‐binding conditions. In all studied cases, the proposed model fits the measured breakthrough curves better than the standard model. Moreover, the minimal number of radial flow zones that are required to accurately describe observed breakthrough curves and the estimated flow fractions through these zones provide valuable information for the analysis and optimization of internal module designs.
Overexpressed epidermal growth factor receptor (EGFR)‐induced progestin insensitivity in human endometrial carcinoma cells by the EGFR/mitogen‐activated protein kinase signaling pathway
Authors: Ai Zhihong , Wang Juan , Wang Yudong , Lu Lihua , Tong Jianqian , Teng Yincheng 
Published: May 2010

AbstractBACKGROUND:Fertility‐sparing management is an important treatment for young women who have endometrial carcinoma (EC). Many patients with EC exhibit insensitivity or resistance to progestin therapy, and the molecular mechanisms of that insensitivity and resistance have been elusive. Epidermal growth factor receptor (EGFR) overexpression has been observed in EC, but the roles of EGFR in progestin resistance have not been investigated.METHODS:EGFR and progesterone receptor isotype B (PR‐B) messenger RNA and protein levels were determined in EC tissue samples and cell lines by immunohistochemical, real‐time reverse transcriptase‐polymerase chain reaction and Western blot analyses. The biologic function of EGFR in the regulation of PR‐B expression and induced progestin resistance was investigated by transfecting recombinant plasmids that expressed EGFR into Ishikawa EC cells. In addition, the role of the mitogen‐activated protein kinase (MAPK) signal pathway was investigated by Western blot analysis.RESULTS:EGFR was detected in 60% of PR‐B–positive samples and in 90.5% of PR‐B–negative samples (P = .015). EGFR expression was higher in progestin‐resistant KLE EC cells than in progestin‐sensitive Ishikawa EC cells. In contrast, PR‐B expression was higher in Ishikawa cells than KLE cells. Higher EGFR expression reduced sensitivity to progestin and decreased PR‐B expression in Ishikawa cells; it also abnormally activated the MAPK signaling pathway and inhibited cell apoptosis. The EGFR tyrosine kinase‐specific inhibitor AG1478 effectively inhibited the proliferation of EC cells that overexpressed EGFR.CONCLUSIONS:The current results indicated that EGFR overexpression may play an important role in reducing sensitivity to progestin treatment in EC. An EGFR tyrosine kinase‐specific inhibitor may be useful in the treatment of EC. Cancer 2010. © 2010 American Cancer Society.
Recent Advances in Gyrokinetic Full‐f Particle Simulation of Medium Sized Tokamaks with ELMFIRE
Authors: Janhunen S.J. , Kiviniemi T.P. , Heikkinen J.A. , Korpio T. , Leerink S. , Nora M. , Ogando F. 
Published: May 2010

AbstractLarge‐scale kinetic simulations of toroidal plasmas based on first principles are called for in studies of transition from low to high confinement mode and internal transport barrier formation in the core plasma. Such processes are best observed and diagnosed in detached plasma conditions in mid‐sized tokamaks, so gyrokinetic simulations for these conditions are warranted. A first principles test‐particle based kinetic model ELMFIRE [1] has been developed and used in interpretation [1, 2] of FT‐2 and DIII‐D experiments. In this work we summarize progress in Cyclone (DIII‐D core) and ASDEX Upgrade pedestal region simulations, and show that in simulations the choice of adiabatic electrons results in quenching of turbulence (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A Statistical Approach to Neutral Transport in Turbulent Plasmas
Authors: Marandet Y. , Mekkaoui A. , Reiter D. , Börner P. , Genesio P. , Rosato J. , Capes H. , Koubiti M. , Godbert‐Mouret L. , Stamm R. 
Published: May 2010

AbstractIn this work we present a statistical model aimed at retaining edge turbulence fluctuations in the EIRENE neutral transport code. The model relies on sampling a large number of plasma backgrounds, using a given 1 point PDF and a 2 points correlation function, and computing the corresponding average quantities (neutral density profile, …). Its implementation is validated using a simplified case for which the calculations can be carried out analytically. An intuitive picture of neutral transport in turbulent plasmas is presented (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)