bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomic survival prediction with liver metastases in colorectal cancer.
Authors: Park Inae , Lee Misuk , Shivakumar Jeevan , Park Sungjae 
Published: June 2024

e15584 Background: The survival outcome of colorectal cancer depends upon staging and the presence of metastases. Nonetheless, there isn’t a reliable prediction model for overall survival (OS) specifically tailored to patients with colorectal cancer who have liver metastases. Consequently, this study aims to find radiomic features that can be utilized to predict OS of colorectal cancer with liver metastases. Methods: We utilized the Colorectal Liver Metastases data set in The Cancer Imaging Archive (TCIA). Overall, 197 patients with colorectal cancer metastatic to the liver were identified. Semi-automatic segmentation of liver metastases was used to extract radiomic features including Gray-Level Co-occurrence (glcm), Gray-Level Run Length Matrix (glrlm), Gray-Level Size Zone Matrix (glszm), Gray-Level Dependence Matrix (gldm), and Neighborhood Gray-Tone Difference Matrix (ngtdm). 3D Slicer was used to extract radiomic features. We tested a Cox proportional hazards model in each radiomics feature to predict OS. Results: Total 107 radiomic features were extracted from pre-segmented liver metastases on patients’ Computed Tomography images. Among them, original shape sphericity, original glcm correlation, original gldm DependenceEntropy, and original glrlm RunEntropy were statistically significant for the prediction of OS, with a hazard ratio of -2.16 (CI 0.01-0.92; p value 0.04), 1.54 (CI 1.5-14.0; p value 0.006), 0.51 (CI 1.0-2.5; p value 0.02), and 0.52 (CI 1.0-2.6; p value 0.03), respectively. Conclusions: Our data analysis indicates crucial radiomic features that hold promise for predicting the clinical outcome of patients with colorectal cancer who have liver metastases. Future research with a larger sample size is warranted for the external validation of our results.
A phase 1 trial evaluating the safety, tolerability, PK, and preliminary efficacy of QTX3034, an oral G12D-preferring multi-KRAS inhibitor, in patients with solid tumors with KRASG12D mutation.
Authors: Patnaik Amita , Pelster Meredith , Hong David S. , Strickler John H , Garrido-Laguna Ignacio , Aguirre Andrew , Curran Dominic , Woo Tina , Spira Alexander I. 
Published: June 2024

TPS3172 Background: KRAS is one of the most mutated driver oncogenes across solid tumors, and KRAS G12D missense mutations have high prevalence in pancreatic, colorectal (CRC), and endometrial cancers. QTX3034 is a highly-selective, non-covalent, orally bioavailable, multi-KRAS inhibitor with potent activity across several KRAS variants, particularly G12D. QTX3034 binds to GDP-bound forms of mutant and wild-type KRAS with (sub)nanomolar affinities, allosterically inhibiting its conversion to the active state. QTX3034 inhibits KRAS signaling in in vitro studies and displays synergy with EGFR inhibitors. In vivo evaluation of QTX3034 resulted in significant tumor growth inhibition across various tumor models, with tumor regressions observed in 100% of animals in both HPAC pancreatic and GP2D colorectal KRAS G12D xenograft models. QTX3034 exhibits brain penetration in preclinical studies, including an orthotopic model of intracranial efficacy. This clinical trial is now enrolling patients with advanced solid tumors harboring a KRASG12D mutation. Methods: This is a first-in-human, multicenter, open-label phase 1 study in adult patients with advanced solid tumors with KRASG12D mutations, without prior direct KRAS inhibitor treatment (NCT06227377). The primary objectives are to evaluate the safety and tolerability and to determine maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of QTX3034 alone, and in combination with cetuximab. Secondary objectives are characterization of the PK profile and preliminary antitumor activity. Part 1 consists of two dose-escalation arms: QTX3034 monotherapy (advanced solid tumors) and QTX3034 plus cetuximab (CRC) and will enroll 3-4 subjects per cohort in a Bayesian Logistic Regression Model (BLRM) design. QTX3034 will be administered orally in 21-day cycles until disease progression, intolerable toxicity, or withdrawal from treatment. Exploratory paired biopsies will be collected in Cycle 2 in a group of patients in the dose-escalation phase. Serial ctDNA will be collected in all patients. Following identification of a RP2D, QTX3034 will be evaluated in dose-expansion cohorts of up to 30 patients with various KRASG12D mutated tumor types to determine preliminary activity: pancreatic cancer, CRC, non-small cell lung cancer and endometrial cancer. To further optimize the recommended dose, patients will be randomized between two dose levels in the pancreatic cancer cohort. QTX3034 plus cetuximab will be explored following identification of a recommended combination dose in patients with CRC. Clinical trial information: NCT06227377 .
Keyhole Fenestration for Cerebrospinal Fluid Leaks in the Thoracic Spine: Quantification of Bone Removal and Microsurgical Anatomy
Authors: Volz Florian , Doria-Medina Roberto , Fung Christian , Wolf Katharina , El Rahal Amir , Lützen Niklas , Urbach Horst , Loidl Theresa Bettina , Hubbe Ulrich , Klingler Jan-Helge , Beck Jürgen 
Published: June 2024

BACKGROUND AND OBJECTIVE:
A safe working trajectory is mandatory for spinal pathologies, especially in the midline, anterior to the spinal cord. For thoracic cerebrospinal fluid (CSF) leaks, we developed a minimally invasive keyhole fenestration. This study investigates the necessary bone removal for sufficient exposure of different leak types particularly regarding weight-bearing structures.

METHODS:
In this retrospective case series between January 2022 and June 2023, the volume of bone resection and the axial and sagittal diameter of hemilamina defects after closure through keyhole fenestration were quantified. The involvement of facet joints and pedicles was qualitatively rated. Demographic (age, sex, body mass index, leak type) and surgical data (blood loss, surgery time, discharge after surgery) and complications were analyzed.

RESULTS:
Thirty-three patients with 34 approaches were included. The volume of resected bone was 1.5 cm3, and the diameter of the hemilamina defect was 17.8 mm in the sagittal and 15.1 mm in the axial plane. Facet joints were uninvolved in 24% and partly resected in 74%, and one facet joint was resected completely. Pedicles remained intact in 71% and were minimally involved in 29%. The median surgery time was 93 minutes, blood loss was 45 mL, and discharge was 4 days after surgery. Three patients (9%) needed revision surgery. No relevant and persisting morbidity occurred. Within the median follow-up period of 10 months, no stabilizing surgery was necessary. No permanent neurological deficit occurred.

CONCLUSION:
The keyhole fenestration leaves weight-bearing structures like facet joints and pedicles intact in most cases. The limited, penny-sized bone resection is sufficient to reach and close thoracic CSF leaks Type 1, 2, and 3 from the anterior midline to the ganglion. For experienced centers, it is a universal minimally invasive approach for treating all CSF leaks.
Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1−/− mice.
Authors: Atkins Richard Matthew , Pantalia Meghan , Skaggs Christopher , Lau Alexander Ku , Mahmood Muhammad Bilal , Anwar Muhammad Mubeen , Barron Lindsay , Eby Bonnie , Khan Usman , Tsiokas Leo , Lau Kai 
Published: June 2024

ABSTRACT
Metabolic syndrome has become a global epidemic, affecting all developed countries and communities with growing economies. Worldwide, increasing efforts have been directed at curbing this growing problem. Mice deleted of the gene encoding Type 1 Transient Receptor Potential Canonical Channel (Trpc1) were found to weigh heavier than controls. They had fasting hyperglycemia and impaired glucose tolerance compared with wild-type controls. Beyond 1 year of age, plasma triglyceride level in Trpc1−/− mice was elevated. Plasma cholesterol levels tended to be higher than in controls. The livers of Trpc1−/− mice were heavier, richer in triglyceride, and more echogenic than those of controls on ultrasound evaluation. Hematocrit was lower in Trpc1−/− mice of both genders beginning at the second to third months of age in the absence of bleeding or hemolysis. Measured by the indirect tail-cuff method or by the direct arterial cannulation, blood pressures in null mice were lower than controls. We conclude that TRPC1 gene regulates body metabolism and that except for hypertension, phenotypes of mice after deletion of the Trpc1 gene resemble mice with metabolic syndrome, suggesting that this could be a good experimental model for future investigation of the pathogenesis and management of this disorder.
Flavonols do not affect aphid load in green or senescing birch leaves but coincide with a decrease in Photosystem II functionality
Authors: Mattila Heta , Khorobrykh Sergey , Tyystjärvi Esa 
Published: June 2024

ABSTRACT
Instead of red anthocyanins, birches synthesise colourless (to human eye), UV-absorbing flavonols during autumn senescence. To test if flavonols protect against insects, and if leaves with high or low amounts of flavonols differ in their photosynthetic functions, aphid-free and aphid-infested green and senescing birch leaves were collected from outdoor-grown trees and analysed. Photosynthetic parameters were greatly affected by the leaf chlorophyll content (i.e. the phase of senescence). Photochemical quenching and the amount of functional Photosystem I decreased linearly with chlorophyll content, while FV/FM (Photosystem II functionality) decreased strongly only at the end of senescence. Non-photochemical quenching of excitation energy (NPQ) increased towards the end of senescence. However, no significant differences in the total flavonol amounts, nor in individual flavonol species, were found between aphid-free and aphid-infested leaves, suggesting that flavonols play no role in defence against aphid herbivory. Interestingly, both green and senescing leaves with a high flavonol content showed low FV/FM values. High flavonol content slowed down PSII photoinhibition and improved recovery, but only in green leaves. Previously, we proposed that anthocyanins provide an additional sink for photosynthates at the nitrogen resorption phase during autumn senescence, and the present data may suggest that flavonol synthesis plays a similar role.
Antibiotic treatment to prevent pediatric acute otitis media infectious complications: A meta-analysis
Authors: Smolinski Nicole E. , Djabali Emma J. , Al-Bahou Julie , Pomputius Ariel , Antonelli Patrick J. , Winterstein Almut G. 
Published: June 2024

Background
Most US children with acute otitis media [AOM] receive prompt antibiotic treatment, though guidelines encourage watchful waiting. Previous systematic reviews of antibiotics versus watchful waiting have focused on symptom resolution and RCTs, limiting the assessment of serious, rare complications. We sought to evaluate these complications by including observational studies.

Methods
RCTs and observational studies that compared antibiotics to placebo or watchful waiting for pediatric clinician diagnosed AOM were identified [PubMed/MEDLINE, Embase, Cochrane Database of Systematic Reviews, Central Register of Controlled Trials, and Web of Science] and reviewed for meta-analysis. Two reviewers independently extracted study characteristics, patient characteristics, and outcomes. We assessed publication bias, study bias with ROBINS-1 and RoB-2 and used random-effects models to assess treatment effects.

Results
24 studies were included. Antibiotics decreased the risk of acute mastoiditis [incidence 0.02%, RR 0.48, 95% CI 0.40–0.59; NNT 5,368]. This protective effect may be underestimated because of misclassification of non-suppurative conditions as AOM. Intracranial complications remained too rare to assess. Antibiotics markedly increased the risk of adverse effects [incidence 10.5%, RR 1.49, 1.27–1.73; NNH 23]. Studies used non-specific criteria for acute mastoiditis, potentially underestimating treatment effects.

Conclusions
Prompt antibiotic therapy reduces the risk for some AOM complications. The NNT to prevent serious, rare complications is high, while the NNH is relatively low. Large-scale population-based observational studies using real-world datasets with validated measures of severe complications are needed to improve understanding of risk factors for serious AOM complications, facilitate more selective antibiotic therapy, and optimize individual outcomes and public health.
Understanding the burden of poor mental health and wellbeing among persons affected by leprosy or Buruli ulcer in Nigeria: A community based cross-sectional study
Authors: Ossai Edmund Ndudi , Ekeke Ngozi , Esmai-Onyima Amaka , Eze Chinwe , Chinawa Francis , Iteke Obiora , Henry Precious , Chukwu Joseph N. , Nwafor Charles , Murphy-Okpala Ngozi , Njoku Martin , Meka Anthony O. , Anyaike Chukwuma 
Published: June 2024

Background
Skin neglected tropical diseases including leprosy and Buruli ulcer (BU)are a group of stigmatizing and disability-inducing conditions and these aspects of the diseases could lead to poor mental health. The study was designed to assess the burden of poor mental health and wellbeing among persons affected by leprosy or BU in Nigeria

Methods
A community based cross-sectional study design was employed. The study involved persons affected by leprosy or BU. Ten local government areas with the highest number of notified leprosy or BU cases between 2014 and 2018 in southern Nigeria were purposively selected. Information were obtained using Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorders-7 (GAD-7), Warwick-Edinburgh Mental Well-being Scale (WEMWBS) and OSLO Social Support Scale. Outcome measure was poor mental health/wellbeing and was determined by proportion of respondents who had depressive symptoms, anxiety disorder and poor mental wellbeing.

Results
A total of 635 persons affected by leprosy or BU participated in the study. The mean age of respondents was 43.8±17.0 years and highest proportion, 22.2% were in age group, 40–49 years. Majority of respondents, 50.7% were males. A higher proportion of respondents, 89.9% had depressive symptoms, 79.4% had anxiety disorders and 66.1% had poor mental wellbeing. Majority, 57.2% had poor mental health/wellbeing. Among the respondents, there was a strong positive correlation between depression and anxiety scores, (r = 0.772, p<0.001). There was a weak negative correlation between depression score and WEMWBS score, (r = -0.457, p<0.001); anxiety score and WEMWBS score, (r = -0.483, p<0.001). Predictors of poor mental health/wellbeing included having no formal education, (AOR = 1.9, 95%CI: 1.1–3.3), being unemployed, (AOR = 3.4, 95%CI: 2.2–5.3), being affected by leprosy, (AOR = 0.2, 95%CI: 0.1–0.4) and having poor social support, (AOR = 6.6, 95%CI: 3.7–11.8).

Conclusions
The burden of poor mental health/wellbeing among persons affected by leprosy or BU is very high. There is need to include mental health interventions in the management of persons affected with leprosy or BU. Equally important is finding a feasible, cost-effective and sustainable approach to delivering mental health care for persons affected with leprosy or BU at the community level. Improving educational status and social support of persons affected by leprosy or BU are essential. Engaging them in productive activities will be of essence.
Estudo comparativo entre a sustentabilidade de habitações de interesse social com foco nos materiais de três sistemas construtivos diferentes
Authors: Souza Cristian Moreira de , Recio María Ángeles Lobo 
Published: June 2024

Construir habitações de interesse social sustentáveis para uma população crescente desafia as políticas públicas e a indústria da construção civil. O governo federal visa zerar o déficit habitacional até 2026, fornecendo dois milhões de unidades habitacionais. Nesse contexto, uma pesquisa bibliográfica em bases de dados foi planejada para propor, do ponto de vista da sustentabilidade, o sistema construtivo mais adequado para a construção das habitações de interesse social: Wood-Frame, Paredes de Concreto ou Alvenaria Convencional. Foram estudados parâmetros sociais, ambientais e econômicos. Os parâmetros sociais foram estudados qualiquantitativamente, onde foram levados em consideração a limitação geográfica, aceitação social, durabilidade, manutenção, conforto térmico e acústico, segurança contra o fogo e tempo de execução. Entre os aspectos ambientais, foram quantitativamente calculados o CO2 emitido e a energia incorporada para cada material, e qualitativamente a renovabilidade, desperdício, resíduos, descarte, reciclagem e impactos ambientais. Em seguida foram elaboradas tabelas de score dos parâmetros estudados numa tentativa de estabelecer a sustentabilidade. O estudo econômico foi quantitativo. Por fim, o sistema construtivo mais sustentável foi o Alvenaria Convencional. Com o custo de 2 milhões de habitações em Alvenaria Convencional, poderiam ser atendidas apenas 1.051.490 famílias com habitações em Wood-Frame (53%). Também foi possível concluir em quais parâmetros cada material destaca-se menos, para o possível desenvolvimento futuro de soluções para melhorar o atendimento dessa elevada demanda de materiais.

Palavras-chave: sustentabilidade; habitação de interesse social; sistemas construtivos
Human Ontogeny in Aristotle and Theophrastus
Authors: Roreitner Robert 
Published: June 2024

Abstract
This paper presents a detailed reconstruction of Theophrastus’ account of human ontogeny, which is built around Aristotle’s notoriously difficult claim in Generation of Animals II 3 that “νοῦς alone enters from without.” I argue that this account (which is known to us via quotes from Theophrastus’ de Anima II and On Motion I) provides a viable alternative to the traditional trilemma between naturalist traducianism, creationism, and pre-existence, as well as offering an attractive but so far unappreciated interpretation of Aristotle’s account of human ontogeny. More specifically, I argue that the extant evidence poses a challenge to the two dominant interpretations of “νοῦς from without” in the last decades: a dialectical one, according to which Aristotle ultimately rejects this claim, and a naturalizing one (often inspired by Alexander of Aphrodisias) that obliterates the essential difference between νοῦς and the other parts of the soul.
Industry Impacts of US Unconventional Monetary Policy
Authors: Goto Eiji 
Published: June 2024

Abstract
Conventional monetary policy has been shown to create differential impacts on industry output. This paper looks at unconventional monetary policy to see its differential impacts on industries in the United States. Identification is achieved with zero and sign restrictions within a structural global vector autoregressive framework. The effects of unconventional monetary policy on output have substantial heterogeneity across industries. Furthermore, the effects on output and monetary policy transmission mechanisms are qualitatively similar to that of conventional monetary policy previously reported in the literature. These findings suggest a substitutability between conventional and unconventional monetary policies. Importantly, policymakers can use unconventional monetary policy and be reassured that impacts on specific industries are similar to those using conventional monetary policy.
What is counter-Versailles literature? – At the intersection of humblebrag, irony, and humor
Authors: Zuo Baiyao 
Published: June 2024

Abstract
The counter-Versailles literature (counter-VL) is born out of the resistance to Versailles literature (VL). The latter is in essence the same as humblebrags. Authors of counter-VL pretend to post VL but are essentially making up jokes or expressing ironies and self-mockeries. Based on the samples gathered from Weibo, this study divides counter-VL into two types according to how their non-VL nature is revealed. By identifying the echoed VL strategies, we investigate how the irony of VL and self-mockery are incarnated in counter-VL and result in humorous effects. This study also highlights the social and psychological factors that influence the creation and effects of counter-VL.
Usefulness of neutrophil-to-lymphocyte count ratio, procalcitonin, and interleukin-6 for severity assessment of bacterial sepsis
Authors: Cai Shu-Qian , Xia Tingting , Xu Xiao-Ping 
Published: June 2024

Abstract

Objectives
To explore the usefulness of neutrophil-to-lymphocyte count ratio (NLR), procalcitonin (PCT), and interleukin-6 (IL-6) for the severity assessment of bacterial sepsis.

Methods
This study enrolled 100 patients with bacterial sepsis (disease group) who presented to Jinhua Central Hospital between March 2022 and March 2023 and 90 healthy individuals (control group). The patients were categorized into sepsis (64 cases), severe sepsis (18 cases), and septic shock (18 cases) groups according to the disease severity. The groups were compared in terms of the NLR, PCT, and IL-6, as well as the usefulness of these parameters, both alone and in combination, for the severity assessment of bacterial sepsis.

Results
The NLR, PCT, and IL-6 levels were significantly different among the three groups, with increasing values corresponding with disease aggravation. The area under the curve (AUC) values of the combinations of NLR, PCT, and IL-6 levels were higher than those of single markers. The sensitivity and AUC value of the combination of PCT and IL-6 levels were the highest (0.87), with a similar AUC value of the combination of NLR, PCT, and IL-6 (0.865); however, the specificity was significantly improved with the latter (0.938 vs. 0.859).

Conclusions
NLR, PCT, and IL-6 levels are significantly increased in bacterial sepsis, and the combination of PCT, and IL-6 levels can improve the sensitivity of the evaluation ability for severe sepsis, and is more economical.
A Digital Preservation for the Indonesian First Terminus
Authors: Sulistyani Harmilyanti 
Published: June 2024

Abstract
The presence of modernization in Indonesia is supported by several factors, one of which is the railway network. Unfortunately, despite its importance in Indonesian history, the first terminus in Indonesia – namely, Semarang Station – has almost been forgotten. Conservation efforts are needed to describe the architectural evolution of Semarang Station, which can provide a lens to see the adaptation efforts in the development process and the global impact of the establishment of a railway network in the colony. Moreover, digital reconstruction as architectural preservation is necessary to convey the station’s historical value. Given the limited access and scarcity of architectural drawings for Semarang Station, textual sources were used to validate the information from the visual sources. The digitalization of visual data produced 2D objects that were used as the basis for making 3D models; these 2D objects were identified using textual data to see the relationship between their architectural transformation and the events related to the building. The findings of the architectural morphology analysis were then used as data to produce the 3D models, which were the main target of the digital reconstruction. The result of this process is a reconstruction of the morphology of the Semarang Station that demonstrates its historical value.
Egy kiváló muzeológus, limnológus emlékére : Dr. Forró László (1954–2023)
Authors: Zsuga Katalin , Korponai János 
Published: June 2024

Dr. Forró László nemzetközileg elismert muzeológus, hidrobiológus, a világ planktonikus kisrákfaunájának elkötelezett kutatója (Forró et al. 2008, Forró et al. 2013). Taxonómiai, faunisztikai, ökológiai munkássága nagy jelentőségű mind a hazai, mind a nemzetközi limnológia számára.