bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistent feline coronavirus infection in a cat with cardiac and gastrointestinal signs
Authors: Licitra Beth N , Olarte-Castillo Ximena A , Whit-taker Gary R 
Published: May 2024

Background Feline coronavirus infection causes feline infectious peritonitis in a subset of cats, but can also result in persistent infection. The tissue reservoirs of feline coronavirus and the role of viral persistence in pathogenesis are poorly understood. Aims This study aimed to identify sites of feline coronavirus persistence in a naturally infected cat, identify disease correlates and characterise within-host viral evolution. Methods The study followed a 5-year-old Bengal cat for 6 years and collected non-invasive samples, including faeces and conjunctival, oropharyngeal and saliva swabs. At 11-years-old, the patient was euthanised as a result of respiratory distress, and tissue samples were collected. The authors used hybridisation capture and next-generation sequencing methodologies focused on the feline coronavirus S gene, along with RNA in-situ hybridisation. Results During the study, the patient was diagnosed with inflammatory bowel disease, alimentary small cell lymphoma, chronic rhinitis and mitral valve regurgitation. Feline coronavirus was detected in the nasal cavity, intestine, faeces and conjunctiva in 2017, and in the intestine, faeces and heart in 2022. Sequence analysis showed that the virus adapted to tissue reservoirs over time. Conclusions This study identifies potential feline coronavirus reservoirs. The relationship of persistent feline coronavirus infection to chronic conditions warrants further investigation.
Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial
Authors: Lin Yu-Hao , Zhang Zhi-Jun , Zhong Jin-Qing , Wang Zhi-Yi , Peng Yi-Ting , Lin Yan-Mei , Zhang Huo-Ping , Tian Jian-Qing 
Published: May 2024

Background
Nonalcoholic fatty liver disease (NAFLD) is strongly associated with type 2 diabetes mellitus (T2DM). Lifestyle intervention remains a preferred treatment modality for NAFLD. The glucagon-like peptide (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors have been developed as new glucose-lowering drugs, which can improve fatty liver via an insulin-independent glucose-lowering effect. However, studies exploring the efficacy of GLP-1 receptor agonists combined with SGLT-2 inhibitors in patients with NAFLD and T2DM are scanty. Thus, the present randomised controlled trial aims at comparing the efficacy and safety of semaglutide plus empagliflozin with each treatment alone in patients with NAFLD and T2DM.

Methods
This 52-week double-blinded, randomised, parallel-group, active-controlled trial evaluates the effects of semaglutide, empagliflozin and semaglutide + empagliflozin in 105 eligible overweight/obese subjects with NAFLD and T2DM. The primary outcome will be a change from baseline to week 52 in the controlled attenuation parameter, free fatty acid and glucagon. Secondary endpoints include changes in liver stiffness measurement, liver enzymes, blood glucose, lipid levels, renal function, electrolyte balances, minerals and bone metabolism, cytokines, high-sensitivity C-reactive protein, ferritin, anthropometric indicators, nonalcoholic fatty liver fibrosis score, fibrosis 4 score and homeostatic model assessment for insulin resistance. In addition, intention-to-treat, interim analysis and safety analysis will be performed.

Discussion
This double-blinded, randomised, clinical trial involves a multi-disciplinary approach and aims to explore the synergistic effects of the combination of semaglutide and empagliflozin. The results can provide important insights into mechanisms of GLP-1 receptor agonists and/or SGLT-2 inhibitors in patients with NAFLD and T2DM.

Trial registration
This study has been registered with Chinese Clinical Trial Registry (ChiCTR2300070674).
Investigating the nature of open science practices across complementary, alternative, and integrative medicine journals: An audit
Authors: Ng Jeremy Y. , Lin Brenda , Parikh Tisha , Cramer Holger , Moher David 
Published: May 2024

Background
Open science practices are implemented across many scientific fields to improve transparency and reproducibility in research. Complementary, alternative, and integrative medicine (CAIM) is a growing field that may benefit from adoption of open science practices. The efficacy and safety of CAIM practices, a popular concern with the field, can be validated or refuted through transparent and reliable research. Investigating open science practices across CAIM journals by using the Transparency and Openness Promotion (TOP) guidelines can potentially promote open science practices across CAIM journals. The purpose of this study is to conduct an audit that compares and ranks open science practices adopted by CAIM journals against TOP guidelines laid out by the Center for Open Science (COS).

Methods
CAIM-specific journals with titles containing the words “complementary”, “alternative” and/or “integrative” were included in this audit. Each of the eight TOP criteria were used to extract open science practices from each of the CAIM journals. Data was summarized by the TOP guideline and ranked using the TOP Factor to identify commonalities and differences in practices across the included journals.

Results
A total of 19 CAIM journals were included in this audit. Across all journals, the mean TOP Factor was 2.95 with a median score of 2. The findings of this study reveal high variability among the open science practices required by journals in this field. Four journals (21%) had a final TOP score of 0, while the total scores of the remaining 15 (79%) ranged from 1 to 8.

Conclusion
While several studies have audited open science practices across discipline-specific journals, none have focused on CAIM journals. The results of this study indicate that CAIM journals provide minimal guidelines to encourage or require authors to adhere to open science practices and there is an opportunity to improve the use of open science practices in the field.
Barriers and facilitators of adherence to low-dose aspirin during pregnancy: A co-produced systematic review and COM-B framework synthesis of qualitative evidence
Authors: Vinogradov Raya , Holden Eleanor , Patel Mehali , Grigg Rowan , Errington Linda , Araújo-Soares Vera , Rankin Judith 
Published: May 2024

Introduction
Women at increased risk of developing pre-eclampsia are advised to take a daily low-dose of aspirin from 12 weeks of pregnancy to reduce their risks. Despite the well-established prophylactic effect of aspirin, adherence to this therapy is low. This systematic review aimed to summarise evidence on the barriers and facilitators of adherence to low-dose aspirin to inform intervention development to support decision making and persistence with aspirin use for pre-eclampsia prevention.

Materials and methods
A systematic review and meta-synthesis of qualitative research was co-produced by representatives from charities, and public, clinical and academic members. Eight electronic databases (MEDLINE, PsycINFO, CINAHL, Web of Science, Scopus, EMBASE, Prospero, OpenGrey), archives of charities and professional organisations were searched (between October and November 2023 and re-run in August 2023) using predefined search terms. Studies containing qualitative components related to barriers and facilitators of adherence to low-dose aspirin during pregnancy were included. Quality assessment was performed using the Critical Appraisal Skills Programme checklist for qualitative research. A combination of the COM-B framework with phases of adherence process as defined by international taxonomy was used as the coding framework. Co-production activities were facilitated by use of ‘Zoom’ and ‘Linoit’.

Results
From a total of 3377 papers identified through our searches, five published studies and one dissertation met our inclusion criteria. Studies were published from 2019 to 2022 covering research conducted in the USA, Canada, UK, Netherlands and Australia. Barriers and facilitators to adherence were mapped to six categories of the COM-B for three phases of adherence: initiation, implementation, and discontinuation. The discontinuation phase of adherence was only mentioned by one author. Four key themes were identified relating to pregnancy: ‘Insufficient knowledge’, ‘Necessity concerns balance’, ‘Access to medicine’, ‘Social influences’, and ‘Lack of Habit’.

Conclusions
The COM-B framework allowed for detailed mapping of key factors shaping different phases of adherence in behavioural change terms and now provides a solid foundation for the development of a behavioural intervention. Although potential intervention elements could be suggested based on the results of this synthesis, additional co-production work is needed to define elements and plan for the delivery of the future intervention.

Trial registration
PROSPERO CRD42022359718. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022359718.
The effects of neck exercise in comparison to passive or no intervention on quantitative sensory testing measurements in adults with chronic neck pain: A systematic review
Authors: Osborne Daniel , Jadhakhan Ferozkhan , Falla Deborah 
Published: May 2024

Background
Previous systematic reviews have identified the benefits of exercise for chronic neck pain on subjective reports of pain, but not with objective measures such as quantitative sensory testing (QST). A systematic review was conducted to identify the effects of neck specific exercise on QST measures in adults with chronic neck pain to synthesise existing literature and provide clinical recommendations.

Methods
The study protocol was registered prospectively with PROSPERO (PROSPERO CRD42021297383). For both randomised and non-randomised trials, the following databases and trial registries were searched: AMED, CINAHL, Embase, Google Scholar, Medline, PEDro, PubMed, Scopus, SPORTDiscus, Science Citation Index and Social Science Citation Index from Web of Science Core Collection, clinicaltrials.gov, GreyOpen, and ISRCTN registry. These searches were conducted from inception to February 2022 and were updated until September 2023. Reference lists of eligible studies were screened. Study selection was performed independently by two reviewers, with data extraction and quality appraisal completed by one reviewer and independently ratified by a second reviewer. Due to high heterogeneity, narrative synthesis was performed with results grouped by exercise type.

Findings
Three trials were included. Risk of bias was rated as moderate and the certainty of evidence as low or moderate for all studies. All exercise groups demonstrated statistically significant improvement at an intermediate-term follow-up, with progressive resistance training combined with graded physical training demonstrating the highest certainty of evidence. Fixed resistance training demonstrated statistically significant improvement in QST measures at a short-term assessment.

Interpretation
Fixed resistance training is effective for short-term changes in pain sensitivity based on low-quality evidence, whilst moderate-quality evidence supports progressive resistance training combined with graded physical training for intermediate-term changes in pain sensitivity.
Predictors for seizure relapse in children with epilepsy after antiepileptic drug withdrawal: case-control study
Authors: Triono Agung , Herini Elisabeth Siti , Mangunatmaja Irawan 
Published: May 2024

Background Epilepsy is defined as a neurologic condition caused by a pathological brain condition. Epilepsy patients who have stopped treatment and are seizure-free for two years are considered to have achieved complete remission. Relapse occurs when seizures return after anti-epileptic drug (AED) withdrawal. Several studies reported that frequent seizures, prolonged duration to control seizures, number of AEDs consumed, and abnormal electroencephalography (EEG) found during AEDs tapered, were reported as predictors of relapse.
Methods This retrospective, case-control study was carried out from 2012 – 2016 using multisite medical record evaluation, followed by interviews and EEG examinations. The case group included children with epilepsy who had seizure relapse, while the control group included children with complete remission of epilepsy. Bivariate and multivariate analyses were performed to identify predictors of relapse.
Results Relapse predictors in bivariate analysis were symptomatic etiology epilepsy (OR 5.000; 95%CI 2.345 to 10.660; P<0.001), time to seizure control ?1 year (OR 3.689; 95%CI 1.493 to 9.116; P=0.003), and worsened EEG evolution at pre-withdrawal compared to EEG at the time of diagnosis (OR 2.310; 95%CI 1.132 to 4.717; P=0.021). Statistically significant relapse predictors in multivariate analysis were symptomatic etiology epilepsy (OR 4.384; 95%CI 1.985 to 9.681; P<0.001) and slow (?1 year) time to seizure control (OR 4.355; 95%CI 1.753 to 10.817; P 0.002).
Conclusion Symptomatic etiology epilepsy and time to seizure control ?1 year are independent predictive factors for seizure relapse in children with epilepsy. Therefore, children with these conditions require a longer period and careful, gradual dose reduction before antiepileptic drugs withdrawal.
Occurence and risk factors of tuberculosis infection in orphanage children in Bali
Authors: Clearesta Kartika Eda , Mayangsari Ayu Setyorini Mestika , Wati Dyah Kanya , Purniti Ni Putu Siadi , Suwarba I Gusti Ngurah Made , Artana I Wayan Dharma 
Published: May 2024

Background Tuberculosis (TB) is an infectious disease that is still a common threat worldwide, especially in pediatric populations. TB transmission occurs particularly when the transmitter has no obvious manifestation of the disease. There is a higher incidence of TB infection in children than in the general population, especially in high risk populations such as children in orphanages. However, the incidence of TB infection in orphaned children in Indonesia, including Bali, is unknown.
Objective To describe the incidence and risk factors for TB infection in children in orphanages in Bali.
Methods This case-control study was conducted in 12 orphanages in Bali. Subjects were divided into a case group comprised of children with TB infection, and a control group comprised of those without TB infection. TB infection was diagnosed by positive tuberculin test without clinically confirmed TB.
Results A total of 175 children were recruited as subjects. There were 49 (28.0%) children with TB infection. Bivariate analysis revealed significant associations between density, humidity, ventilation/room area ratio, and area of ??origin with TB infection. Multivariate analysis showed that ventilation/room area ratio and room humidity of ?73% were independently positive correlated with TB infection. Natural lighting and BCG scar were not significantly different between groups.
Conclusion The occurence of TB infection in children residing in orphanages in Bali is high (28%). The risk factors identified independently are lower ventilation and higher room humidity.
Comparative assessment of cognitive function of asthmatic and non-asthmatic children in Ilorin, Nigeria
Authors: Mohammed Salihu Sheni , Ibraheem Rasheedat Mobolaji , Abdulkadir Mohammed Baba , Adeboye Muhammed Akanbi Nurudeen , Gobir Aishatu Ahmed , Johnson Wahab Babatunde Rotimi 
Published: May 2024

Background The presence of asthma in children may negatively impact their cognitive function, possibly due to intermittent hypoxia from repeated acute exacerbations, sleep deprivation, and school absenteeism. However, conflicting reports abound on cognitive performance among children with asthma.
Objective To assess and compare the cognitive function of asthmatic and non-asthmatic children in Ilorin, Nigeria.
Methods This cross-sectional study compared the cognitive performance scores of 66 children with asthma aged 6-17 years, and the corresponding scores of 66 healthy age- and gender-matched children without asthma. Data obtained included sociodemographic, anthropometric, and clinical details. Cognitive function was assessed with the Raven's Progressive Matrices (RPM) psychometric test.
Results The male: female ratio was 1.3:1. The median RPM score of 50.0 [interquartile range (IQR) 25.0-75.0] in children with asthma was significantly higher than that of non-asthmatic children [32.5 (IQR 10.0-50.0)]; (P=0.016). A significantly higher proportion of asthmatic subjects (74.2%) were in the high grade RPM score category compared to the non-asthmatic children’s concomitant proportion (57.6%). Asthmatic subjects were twice as likely to belong to the high grade RPM score category than their non-asthmatic counterparts (OR=2.12; 95%CI 1.02 to 4.44; P=0.043). There was no significant association between RPM score grade and clinical severity of asthma in the subject population (P=0.554).
Conclusion Children with asthma perform better in cognitive function assessment, using RPM test, compared to their non-asthmatic counterparts in Ilorin, Nigeria.
Nilai-Nilai Maqāṣid Dibalik Pertemuan Dengan Allah (Liqāallah) dalam QS. al-Kahfi [18]: 110 Perspektif Tafsir Maqāṣidi
Authors: Awwaliyyah Saadah , Ismail  
Published: May 2024

Mayoritas manusia yang hidup saat ini menganggap pertemuan dengan Allah hanyalah fiktif belaka, belum tentu dirasakan oleh setiap manusia, juga hanya dapat di nikmati setelah adanya hari kebangkitan. Sehingga sangat mudah mengabaikan keberadaan Allah dengan menafikan nilai-nilai kebaikan menuju Allah. Tujuan tulisan ini untuk menggali makna Liqāallah denga mengangkat nilai-nilai maqāṣid al-Qur’an dan maqāṣid alsharia’ah dalam QS. Al-Kahfi[18]:110. Artikel ini termasuk jenis penelitian kepustakaan dengan metode analisis deskriptif yang diteliti menggunakan pendekatan tafsir maqashidi. Hasil penelitian ini menunjukkan bahwa lafadz Liqāallah tidak hanya bermakna pertemuan dengan Allah setelah hari akhir, tetapi juga bermakna ganjaran kebaikan dari Allah yang dapat diterima semasa hidup di dunia. Penulis juga menemukan nilai-nilai maqāṣid al-Qur’an dan maqāṣid al-sharia’ah dalam QS. AlKahfi[18]:110 yang dapat diterapkan dalam kehidupan seharihari. Hasil penelitian ini diharapkan dapat mengembalikan keyakinan manusia akan keberadaaan Allah dengan menanamkankembali nilai-nilai kebaikan menuju Allah.
[The majority of people living today think that meeting God is just a fiction, not necessarily felt by every human being, and can only be enjoyed after the resurrection day. So it is very easy to ignore the existence of Allah by denying the values of goodness towards Allah. The aim of this article to explore the meaning of Liqāallah by highlighting the values of maqāṣid al-Qur’an and maqāṣid alsharia’ah in the QS. Al-Kahfi[18]:110. This article is a type of library research with a descriptive analysis method that is researched using the maqāṣidi interpretation approach. The result of this research show that Liqāallah does not only mean meeting with Allah after thelast day, but it also of goodness from Allah can be received during life in the world. The author also finds the values of maqāṣid al-Qur’an and maqāṣid al-sharia’ah in the QS. Al-Kahfi[18]:110 which can be applied in everyday life. The result of this research are expetected to restore human belief in the exsistence of God by re-instilling good values toward Allah].
RTScan: Efficient Scan with Ray Tracing Cores
Authors: Lv Yangming , Zhang Kai , Wang Ziming , Zhang Xiaodong , Lee Rubao , He Zhenying , Jing Yinan , Wang X. Sean 
Published: May 2024

Indexing is a core technique for accelerating predicate evaluation in databases. After many years of effort, the indexing performance has reached its peak on the existing hardware infrastructure. We propose to use ray tracing (RT) cores to move the indexing performance and efficiency to another level by addressing the following technical challenges: (1) the lack of an efficient mapping of predicate evaluation to a ray tracing job and (2) the poor performance by the heavy and imbalanced ray load when processing skewed datasets. These challenges set obstacles to effectively exploiting RT cores for predicate evaluation.
In this paper, we propose RTScan, an approach that leverages RT cores to accelerate index scans. RTScan transforms the evaluation of conjunctive predicates into an efficient ray tracing job in a three-dimensional space. A set of techniques are designed in RTScan, i.e., Uniform Encoding, Data Sieving, and Matrix RT Refine, which significantly enhances the parallelism of scans on RT cores while lightening and balancing the ray load. With the proposed techniques, RTScan achieves high performance for datasets with either uniform or skewed distributions and queries with different selectivities. Extensive evaluations demonstrate that RTScan enhances the scan performance on RT cores by five orders of magnitude and outperforms the state-of-the-art approach on CPU by up to 4.6×.
Subthalamic nucleus synchronization between beta band local field potential and single‐unit activity in Parkinson's disease
Authors: Bayman Eric , Chee Keanu , Mendlen Madelyn , Denman Daniel J. , Tien Rex N. , Ojemann Steven , Kramer Daniel R. , Thompson John A. 
Published: May 2024

AbstractLocal field potential (LFP) oscillations in the beta band (13–30 Hz) in the subthalamic nucleus (STN) of Parkinson's disease patients have been implicated in disease severity and treatment response. The relationship between single‐neuron activity in the STN and regional beta power changes remains unclear. We used spike‐triggered average (STA) to assess beta synchronization in STN. Beta power and STA magnitude at the beta frequency range were compared in three conditions: STN versus other subcortical structures, dorsal versus ventral STN, and high versus low beta power STN recordings. Magnitude of STA‐LFP was greater within the STN compared to extra‐STN structures along the trajectory path, despite no difference in percentage of the total power. Within the STN, there was a higher percent beta power in dorsal compared to ventral STN but no difference in STA‐LFP magnitude. Further refining the comparison to high versus low beta peak power recordings inside the STN to evaluate if single‐unit activity synchronized more strongly with beta band activity in areas of high beta power resulted in a significantly higher STA magnitude for areas of high beta power. Overall, these results suggest that STN single units strongly synchronize to beta activity, particularly units in areas of high beta power.
Zur Bedeutung der Hintergrundbelastung bei toxikologischen Untersuchungen an historischem Schriftgut
Authors: Arndt Torsten , Stemmerich Karsten 
Published: May 2024

Zusammenfassung
Im 19. Jahrhundert wurden zur Gestaltung von Büchern oft prächtige schwermetallhaltige Pigmente verwendet. Ist das in unseren Bibliotheken und Museen bewahrte historische Schriftgut dadurch „Gefährlich Schön“ (Hawksley)? Geht von den auf den Buchschnitten und -einbänden aufgelagerten und zum Teil auch im Staub enthaltenen arsenhaltigen Pigmenten eine Gesundheitsgefährdung aus? Wir gehen diesen Fragen nach, indem wir die an der Universitätsbibliothek Kiel erhobenen Daten in Bezug zur natürlichen Arsen-Hintergrundkonzentration sowie zur täglichen obligaten Arsenaufnahme setzen.