bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prisonnier de guerre ? De l’armée italienne au goulag, l’itinéraire du jésuite Pietro Leoni (1941-1955)
Authors: Pettinaroli Laura 
Published: April 2024

L’itinéraire du jésuite Pietro Leoni permet d’aborder les longues captivités en URSS au lendemain de la guerre et la réversibilité des rôles en contexte de guerre et de sortie de guerre. Aumônier militaire puis missionnaire catholique à Odessa, Leoni est un acteur de l’assistance matérielle et spirituelle auprès de l’armée italienne et des populations ukrainiennes. Arrêté en avril 1945, il est interné en URSS et devient lui-même l’objet d’une assistance jusqu’à sa libération en 1955.
Littérature pour enfants et idéologie en URSS (1920-1935) : l’exemple de El reloj o las aventuras de Petika de Leonid Panteleev
Authors: Delanos Marie 
Published: April 2024

En 2021, la Contemporaine a acquis un conte pour enfants, El reloj , écrit par Léonid Panteleev. Bien qu’il s’agisse d’une traduction en espagnol, l’œuvre reste un témoin privilégié des années 1920-1935 en URSS. Son analyse permet de mettre en avant des traits distinctifs de l’époque, tant par le sujet traité (l’enfance abandonnée) que par le contenu idéologique. Deux particularités qui expliquent que l’œuvre soit rapidement tombée dans l’oubli dans son propre pays.
La docimocratie polytechnicienne. Le concours, contrôle méritocratique des carrières d’officiers des armes savantes en France après la Révolution (1794-1919)
Authors: Couqueberg Sam 
Published: April 2024

Cette étude retrace l’histoire du concours comme clé de voûte de la fonctionnarisation des officiers au xix e siècle. Ce système « docimocratique » met en pratique la révolution idéologique qui, à la charnière des deux siècles révolutionnaires, entend situer le mérite comme seul vecteur de distinction sociale. Le concours de l’École polytechnique, fondée en 1794, s’impose progressivement comme l’instrument étatique privilégié du contrôle des carrières d’officiers.
L’habitat lorrain du Néolithique moyen et final de Saint-Julien-lès-Metz en Moselle
Authors: Brunet Véronique , Auxiette Ginette , Berrio Laura , Bonnardin Sandrine , Cayol Nicolas , Cubas Miriam , Denaire Anthony , Hachem Lamys , Imbeaux Marie , Maréchal Denis , Monchablon Cécile , Rolet Joël , Pailler Yvan , Salavert Aurélie , Wiethold Julian 
Published: April 2024

La fouille de Saint-Julien-lès-Metz réalisée dans un cadre préventif s’est déroulée il y a une vingtaine d’années et sa publication a conduit à la reprise complète des études de mobiliers. Le site se caractérise par un état de conservation relativement bon. L’ensemble illustre trois périodes du Néolithique sous des angles parfois inédits et constitue un apport majeur pour la compréhension des communautés villageoises lorraines. Les trois occupations reconnues s’étendent du Ve au IIIe millénaire et sont séparées par des hiatus chronologiques. La première occupation attestée remonte à la première partie du Néolithique moyen. Deux bâtiments et une succession de fosses polylobées sont les éléments principaux de ce gisement. Ils sont caractéristiques des sites de la culture de Grossgartach et offrent une vision inédite d’un habitat structuré en plateau. La deuxième est datée de la seconde partie du Néolithique moyen. Une succession de fosses polylobées est le seul élément de ce qu’il reste d’un habitat Bischheim. Ces structures sont récurrentes sur les sites lorrains contemporains. La dernière occupation est datée du Néolithique final. Une structure de combustion et un silo sont les seuls éléments restants d’un probable habitat campaniforme.
Quality of patient-oriented online information on treatment of dementia: A comparative assessment of web pages in English and Hindi language
Authors: Das Subhash , Singh Swarndeep , Kaur Gurneet , Sharma Sanya 
Published: April 2024

Background:Management of dementia involves a multidisciplinary approach which also requires active participation from family members and caregivers. Thus, having easy access to information about dementia care is pertinent. Internet-based information is an emerging method for the same.Aim:To perform a comparative assessment of patient-oriented online information available on treatment of dementia over web pages in English and Hindi language.Methods:Observational study was conducted online through a general internet search engine (www.google.com). Web pages containing patient-oriented online information on treatment of dementia in English and Hindi were reviewed to assess their content and quality, esthetics, and interactivity. Appropriate descriptive and inferential statistics were conducted using the Statistical Package for the Social Sciences.Results:A total of 70 web pages met the eligibility criteria. Content quality assessed using the DISCERN score was significantly higher for English web pages compared to Hindi web pages (P< 0.01). About 72.4% (21/29) of English and only 9.8% (4/41) of Hindi web pages had a total DISCERN score of 40 or above, indicating good quality. For esthetics, the median score for English pages was significantly higher than for Hindi web pages (P< 0.01). The web pages with Health On Net (HON) certification had significantly better content quality.Conclusion:Our study revealed a scarcity of good quality online information about dementia and its treatment, especially in the Hindi language. English language websites showed better content quality than Hindi websites. HON Code label might be used as an indicator of better content quality for online resources informing on dementia treatment by lay people.
Female sexual dysfunction—knowledge, attitude, practices, and barriers encountered by medical fraternity across the country: A web-based cross-sectional study
Authors: Kaundal Asmita , Renjhen Prachi , Kumari Rajeshwari , Jha Ravi P. , Marwaha Poojan D. , Kaur Harpreet , Kaushal Sushruti , Malik Nisha , Gupta Jyoti 
Published: April 2024

ABSTRACT

Introduction:
Sexual dysfunction in women is common yet often remains underdiagnosed due to the lack of adequate training and experience of the doctors to manage female sexual dysfunctions. This study was done to assess the knowledge and attitude of medical professionals toward female sexual dysfunction and the various practices and barriers they encounter while managing women with sexual dysfunction.

Materials and Methods:
A web-based cross-sectional study was done using the snowball sampling method. A well-structured, self-administered, and pre-validated questionnaire containing 27 items was administered through social media. Data was collected and evaluated to assess their knowledge, practices they follow, and barriers encountered while managing female sexual dysfunction.

Results:
A total of 513 doctors participated in the study. Out of all, only 11.1% of the doctors were often seeing patients with sexual dysfunction. Loss of desire (44%), painful intercourse (33%), lack of lubrication (18%), and anorgasmia (5%) are common symptoms with which women present. The majority of doctors (78.9%) were comfortable in starting a conversation, over half (52.6%) were confident in making a diagnosis, and 51.3% were confident in providing sexual counseling. Yet, only 11.1% were routinely screening women for sexual dysfunctions, and 33.8% were providing counseling regarding sexual issues. Lack of time (31.6%), lack of adequate training (57.3%), unavailability of effective treatment (11.9%), patient discomfort (60.62%), and patient’s reluctance to seek treatment (15.8%) were the barriers encountered by doctors. When assessed for knowledge, around 30.9% had excellent knowledge (≥75th percentile) about female sexual dysfunction.

Conclusion:
Sexual dysfunction among women is an important health issue that significantly affects the social, mental, and physical well-being of those suffering from it. Screening for sexual dysfunction should be done routinely in day-to-day clinical practice to improve the overall quality of life of a couple.
Cyproheptadine in serotonin syndrome: A retrospective study
Authors: Prakash Sanjay , Patel Harsh , Kumar Sunil , Shah Chetsi S. 
Published: April 2024

ABSTRACT

Objective:
Serotonin syndrome (SS) is an iatrogenic life-threatening condition caused by serotonergic agents. The treatment for SS involves the administration of a serotonin antagonist (cyproheptadine). However, the dosing schedule for cyproheptadine is not uniform in the literature.

Methods:
We retrospectively evaluated 23 adult patients (>18 years) admitted to the Neurology Department and met the Hunter criteria for SS.

Results:
The mean age was 35.2 years, and 52% were female. Ten patients were managed in the intensive care unit (ICU), whereas thirteen patients were admitted to the ward. Hyperreflexia was the most common clinical feature (100%), followed by clonus (91%), tachycardia (83%), and tremor (83%). Other common clinical features were rigidity (65%), increased bowel sound (61%), diaphoresis (48%), fever (43%), hypertension (39%), and myoclonus (30%). All but one patient received two or more serotonergic drugs. Tramadol was the most common serotonergic agent (39%), followed by sodium valproate (21%), and amitriptyline (21%). Cyproheptadine was administered to all patients. All patients admitted in the ICU received a loading dose of 12 mg followed by 2 mg every 2 h for at least 24 h. All patients admitted to the ward were given 4 mg of cyproheptadine three times each day. Every patient showed at least some response to cyproheptadine within 24 h. The total doses of cyproheptadine and the length of treatment differed between patients.

Conclusion:
Any response to cyproheptadine at a therapeutic dose within 24 h, even a partial one, could be a diagnostic indicator of the existence of SS.
Mucormycosis and coronavirus disease 2019: Risk factors, clinical presentation and outcome in a tertiary care centre in North India – What have we learned
Authors: Ansari Ahmad Ghayas , Nasar Ariba , Ashraf Hamid , Mehdi Husaini Syed Haider 
Published: April 2024

Abstract

Aim:
The aim of this study is to determine clinical presentation, risk factors and outcome in patients with mucormycosis and coronavirus disease 2019 (COVID-19).

Introduction:
A wide range of opportunistic infections have been described in patients with COVID-19. Rhino-orbital-cerebral mucormycosis has been increasingly described in patients with COVID-19 disease, but the risk factors and outcomes of such patients are not well described.

Materials and Methods:
This observational study was conducted in Jawaharlal Nehru Medical College, Aligarh, from 1st May 2021 to 31st August 2021 in 50 patients diagnosed with mucormycosis. Clinical features and risk factors were determined and were correlated with the outcome.

Results:
Out of the 50 patients under study, male patients outnumbered female patients and 64% of patients were above 40 years of age. The mean delay before admission was 18 ± 16.9 days. Eighty-six percent of patients were discharged satisfactorily and 14% of patients expired. Eighty-two percent of patients had COVID-19 disease. Diabetes mellitus was present in 84% of the patients and 66% of patients had HbA1C levels above 7. Paranasal sinus involvement was the most common presenting feature (62%). On analysing the factors associated with mortality, serum creatinine (P = 0.001), total leucocyte count (TLC) (P < 0.001) and intracranial involvement of mucormycosis (P = 0.02) showed a statistically significant association. However, only TLC showed a significant association when multivariate logistic regression was performed to identify independent significant risk factors for mortality (P = 0.023 odds ratio 1.28 confidence interval 1.035–1.593).

Conclusion:
Mucormycosis adds to the increasing morbidity and mortality associated with COVID-19 and with early diagnosis and prompt treatment associated with better prognosis.
Quality of life after functional endoscopic sinus surgery for diffuse sinonasal polyposis
Authors: Elesawy Hadeer O B , Ebeid Kamal A H , Aglan Yasser I , Gamea Ahmed M M 
Published: April 2024

Abstract

Background
According to recent research, people with chronic rhinosinusitis and nasal polyposis may have considerable limits in their ability to engage in social, emotional, and physical activities.

Aim
This study’s major goal was to gauge how patients’ quality of life was affected by functional endoscopic sinus surgeries.

Patients and methods
Our prospective study included 30 patients (≥18 years) resistant to medical treatment for 6 months who underwent endoscopic surgery. Lund–Mackay score was done preoperatively. Endoscopic score was done for all patients, and they were asked to rate their symptoms using sinonasal outcome test 22 and rhinosinusitis disability index before surgery and 3, 6, and 12 months following the operation.

Results
At 3 months following the surgery, the test and the index revealed significant improvement of 93 and 55%, respectively, and then the percentage of improvement decreased to 31% for the test and 36% for the index at 12 months postoperatively. Preoperative Lund–Mackay scores were significantly high. Endoscopic scores showed marked improvement, with 82% reduction at 3 months postoperatively, but the reduction percentage deteriorated to 31% at 12 months, indicating relapse. Overall, 30% of patients experienced recurrence between six and 12 months of postoperative follow-up; 33% of them gave history of aspirin intolerance, 33% were asthmatics, and 22% were smokers.

Conclusion
There is evidence that endoscopic surgery may help individuals with nasal polyps achieve better long-term results. Smoking, asthma, and aspirin sensitivity were shown to be linked to a worse long-term result and a greater recurrence risk.
Midazolam infusion might preserve glucose and lipid homeostasis during surgery under general anesthesia: Placebo-controlled comparative study
Authors: Khashaba Mohamed A , Salman Samar A 
Published: April 2024

AbstractBackgroundAnesthesia and surgery each per se is a stressful condition that may affect the postoperative patients’ outcomes. Hyperglycemia is the commonest result of surgical stress response and must be adjusted not only in diabetics to improve outcomes.AimsTo determine changes in blood glucose (BG) and serum lipids and cortisol levels after intraoperative midazolam infusion for patients undergoing surgery under general anesthesia.Patients and Methods:160 ASA I or II non-diabetic patients were randomly divided as Control patients received placebo infusion and Study patients received midazolam infusion (0.35 µg/kg/min). All patients gave blood samples before (S1) and 30-min after the start (S2) and at the end of infusion (S3) for estimation of BG and serum lipids and cortisol levels. The study outcome was the change in the levels of estimated parameters in relation to their preoperative levels.ResultsBG levels estimated in S2 and S3 samples were significantly higher than S1 levels of all patients but were significantly lower in samples of study than control patients. Serum levels of triglycerides and very low-density lipoproteins (VLDL), and cortisol in S3 study samples were significantly lower than in S3 control samples.ConclusionIntraoperative midazolam infusion could minimize surgical stress response with a significant decrease in serum cortisol, triglycerides, and VLDL and significantly lower BG concentrations in comparison to placebo infusion.
Nine-year follow-up of patients receiving recombinant human hepatocyte growth factor nude plasmid DNA for critical limb ischemia: Updated safety and efficacy results
Authors: Gu Yongquan , Cui Shijun , Yu Tong , Liao Lianming , Guo Jianming 
Published: April 2024

Abstract:

CONTEXT:
NL003 is a plasmid engineered to simultaneously express two isoforms of hepatocyte growth factor. The Phase II clinical trial shows that intramuscular injection of NL003 in the affected limb of patients with critical limb ischemia (CLI) is safe and could alleviate pain and promote ulcer healing. The purpose of this study was to evaluate the long-term safety and efficacy of NL003.

METHODS:
A total of 108 participants were evaluated: 32 in the placebo group and 76 in the NL003 group. The primary endpoint was 5-year amputation-free survival and the secondary endpoints were pain, ulcer, and adverse reactions.

RESULTS:
During a mean follow-up period of 10.4 years, the 5-year amputation-free survival rate was 67.1% (51/76) in the NL003 group and 37.5% (12/32) in the placebo group (P < 0.05). The median amputation-free survival was 9.53 years in the NL003 group and 4.51 years in the placebo group. There was no significant difference in the rates of major amputation between the two groups (21.1% vs. 21.9%). Pain relief and ulcer healing tended to favor the NL003 group. No serious adverse reactions such as gene integration and tumor were found during the follow-up.

CONCLUSIONS:
NL003 has a favorable long-term safety profile and may provide long-term benefit for patients with CLI.
The cardiovascular system at high altitude: A bibliometric and visualization analysis
Authors: Zhao Mao-Lin , Lu Zhong-Jie , Yang Li , Ding Sheng , Gao Feng , Liu Yuan-Zhang , Yang Xue-Lin , Li Xia , He Si-Yi 
Published: April 2024

BACKGROUND
When exposed to high-altitude environments, the cardiovascular system undergoes various changes, the performance and mechanisms of which remain controversial.
AIM
To summarize the latest research advancements and hot research points in the cardiovascular system at high altitude by conducting a bibliometric and visualization analysis.
METHODS
The literature was systematically retrieved and filtered using the Web of Science Core Collection of Science Citation Index Expanded. A visualization analysis of the identified publications was conducted employing CiteSpace and VOSviewer.
RESULTS
A total of 1674 publications were included in the study, with an observed annual increase in the number of publications spanning from 1990 to 2022. The United States of America emerged as the predominant contributor, while Universidad Peruana Cayetano Heredia stood out as the institution with the highest publication output. Notably, Jean-Paul Richalet demonstrated the highest productivity among researchers focusing on the cardiovascular system at high altitude. Furthermore, Peter Bärtsch emerged as the author with the highest number of cited articles. Keyword analysis identified hypoxia, exercise, acclimatization, acute and chronic mountain sickness, pulmonary hypertension, metabolism, and echocardiography as the primary research hot research points and emerging directions in the study of the cardiovascular system at high altitude.
CONCLUSION
Over the past 32 years, research on the cardiovascular system in high-altitude regions has been steadily increasing. Future research in this field may focus on areas such as hypoxia adaptation, metabolism, and cardiopulmonary exercise. Strengthening interdisciplinary and multi-team collaborations will facilitate further exploration of the pathophysiological mechanisms underlying cardiovascular changes in high-altitude environments and provide a theoretical basis for standardized disease diagnosis and treatment.
Pengembangan Media Pembelajaran Berbasis Powtoon untuk Meningkatkan Hasil Belajar Siswa pada Materi Sistem Ekskresi Manusia
Authors: Hasugian Ronita , Siagian Gunaria , Silaban Winarto 
Published: April 2024

Penelitian ini bertujuan untuk mengetahui kelayakan media powtoon sebagai media pembelajaran, mengetahui pengaruh penggunaan media powtoon dan mengetahui respon siswa terhadap pengembangan powtoon dan meningkatkan hasil belajar siswa dalam pembelajaran biologi khususnya pada materi sistem ekskresi manusia. Model pengembangan yang digunakan adalah model ADDIE. Penelitian ini penelitian kuantitatif dengan menggunakan instrumen berupa angket dan tes dianalisis dengan uji statistik parametrik. Pengambilan sampel dipilih secara acak dua kelas yaitu kelas XI PMIA 5 dan XI PMIA 6 di SMA Negeri 4 Pematangsiantar. Teknik pengambilan sampel digunakan dengan cara “simple random sampling”, sebanyak 36 orang siswa di kelas XI PMIA 5 sebagai kelas eksperimen menggunakan media powtoon dan sebanyak 36 orang siswa kelas XI PMIA 6 sebagai kelas kontrol tidak menggunakan media powtoon. Jenis penelitian yang digunakan adalah penelitian dan pengembangan (Research & Development) dengan model pengembangan ADDIE. Adapun hasil penelitian ini menunjukkan: (1) Hasil uji kelayakan media pembelajaran powtoon oleh validator ahli materi 78%, ahli desain 84%, ahli bahasa 100% diperoleh persentase rata-rata 87,3% mendapat kategori sangat layak. (2) Hasil respon siswa terhadap media pembelajaran menggunakan powtoon dengan persentase nilai rata-rata 88,5% mendapat kategori sangat layak sedangkan respon guru biologi memperoleh persentase nilai rata-rata nilai 93% mendapat kategori sangat layak. (3) Rata-rata hasil belajar siswa meningkat setelah menggunakan media powtoon dari 42,77% menjadi 78,75% dan respon siswa baik. Dapat dilihat pada uji t nilai Sig.(2-tailed) 0,000<0,05 sehingga Ho ditolak dan Ha diterima. Dengan demikian, dapat disimpulkan bahwa pengaruh media powtoon terhadap hasil belajar siswa pada materi sistem ekskresi manusia baik.
ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ TỔN THƯƠNG MẠCH MÁU Ở BỆNH NHÂN HẸP TẮC ĐỘNG MẠCH ĐÙI-KHOEO
Authors: Hiến Nguyễn Đình , Trường Lê Văn , Anh Lương Tuấn , Chiến Nguyễn Mạnh 
Published: April 2024

Mục tiêu: Mô tả đặc điểm lâm sàng, cận lâm sàng và tổn thương mạch máu ở bệnh nhân hẹp tắc động mạch đùi-khoeo.
Đối tượng và phương pháp nghiên cứu: Phương pháp tiến cứu, theo dõi dọc theo thời gian nghiên cứu, trên 70 người bệnh với cỡ mẫu chân nghiên cứu là 80 chân, tại Bệnh viện Trung ương Quân đội 108 từ tháng 08/2017 – 08/2019.
Kết quả: Trong nghiên cứu, tỉ lệ nam giới chiếm 60,0%. Tuổi trung bình của bệnh nhân là 72,51 ± 10,41 tuổi. Giai đoạn lâm sàng hay gặp nhất là Rutherford 5 (tỉ lệ 43,8%). ABI trung bình trong nghiên cứu là 0,59 ± 0,23. Tổn thương ĐM đùi khoeo đa số là TASC D, với tỉ lệ 93,8%. Chiều dài tổn thương trung bình là 11,14 ± 3,71 cm. Tỷ lệ nhiễm khuẩn loét hoại tử là 8,8%. Tỷ lệ có hẹp động mạch ở ĐM đùi và ĐM khoeo lần lượt là 48,8% và 45%. Tỷ lệ có tắc động mạch ở ĐM đùi và ĐM khoeo lần lượt là 37,5% và 32,5%.
Kết luận: Nghiên cứu cắt ngang về hẹp tắc động mạch đùi-khoeo giúp cải thiện chẩn đoán và điều trị bệnh nhân, đồng thời đóng góp vào phát triển phương pháp can thiệp hiệu quả hơn.