bluuebunny/crossref_metadata_2025_split huggingface dataset:
Active electronic skin: an interface towards ambient haptic feedback on physical surfaces
Authors: Guo Yuan , Wang Yun , Tong Qianqian , Shan Boxue , He Liwen , Zhang Yuru , Wang Dangxiao 
Published: May 2024

AbstractIn the era of ubiquitous computing with flourished visual displays in our surroundings, the application of haptic feedback technology still remains in its infancy. Bridging the gap between haptic technology and the real world to enable ambient haptic feedback on various physical surfaces is a grand challenge in the field of human-computer interaction. This paper presents the concept of an active electronic skin, characterized by three features: richness (multi-modal haptic stimuli), interactivity (bi-directional sensing and actuation capabilities), and invisibility (transparent, ultra-thin, flexible, and stretchable). By deploying this skin on physical surfaces, dynamic and versatile multi-modal haptic display, as well as tactile sensing, can be achieved. The potential applications of this skin include two categories: skin for the physical world (such as intelligent home, intelligent car, and intelligent museum), and skin for the digital world (such as haptic screen, wearable device, and bare-hand device). Furthermore, existing skin-based haptic display technologies including texture, thermal, and vibrotactile feedback are surveyed, as well as multidimensional tactile sensing techniques. By analyzing the gaps between current technologies and the goal of ambient haptics, future research topics are proposed, encompassing fundamental theoretical research on the physiological and psychological perception mechanisms of human skin, spatial-temporal registration among multimodal haptic stimuli, integration between sensing and actuation, and spatial-temporal registration between visual and haptic display. This concept of active electronic skin is promising for advancing the field of ambient haptics, enabling seamless integration of touch into our digital and physical surroundings.
An innovative molecular approach towards the cost-effective entomological authentication of honey
Authors: Zhang Guozhi , Zhang Yanzheng , Yuan Bin , Tiang En Ruth , Li Shanshan , Zheng Huoqing , Hu Fuliang 
Published: May 2024

AbstractHoney authentication and traceability are crucial not only for economic purposes but also for ensuring safety. However, the widespread adoption of cutting-edge technologies in practical applications has been hampered by complex, time-consuming sample pre-treatment processes, the need for skilled personnel, and substantial associated expenses. This study aimed to develop a simple and cost-effective molecular technique to verify the entomological source of honey. By utilizing newly designed primers, we successfully amplified the mitochondrial 16S ribosomal RNA gene of honey bees from honey, confirming the high quality of the extracted DNA. Employing RFLP analysis with AseI endonuclease, species-specific restriction patterns were generated for honey derived from six closely related honey bees of the Apis genus. Remarkably, this method was proven equally effective in identifying heat-treated and aged honey by presenting the same RFLP profiles as raw honey. As far as we know, this is the initial research of the simultaneous differentiation of honey from closely related honey bee species using the restriction endonuclease AseI and mitochondrial 16S rRNA gene fragments. As a result, it holds tremendous potential as a standardized guideline for regulatory agencies to ascertain the insect origins of honey and achieve comprehensive traceability.
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18
Authors: Wolfson David W. , Kim Nam Kyun , Lee Ki Hong , Beyersdorf Jared P. , Langberg Jonathan J. , Fernandez Natasha , Choi Dahim , Zureick Nadine , Kim Tae Yun , Bae Seongho , Gu Jin-Mo , Kirschman Jonathan L. , Fan Jinqi , Sheng Christina Y. , Gottlieb Sen Danielle , Mettler Bret , Sung Jung Hoon , Yoon Young-sup , Park Sung-Jin , Santangelo Philip J. , Cho Hee Cheol 
Published: May 2024

AbstractThe adenovirus-mediated somatic transfer of the embryonic T-box transcription factor 18 (TBX18) gene can convert chamber cardiomyocytes into induced pacemaker cells. However, the translation of therapeutic TBX18-induced cardiac pacing faces safety challenges. Here we show that the myocardial expression of synthetic TBX18 mRNA in animals generates de novo pacing and limits innate and inflammatory immune responses. In rats, intramyocardially injected mRNA remained localized, whereas direct myocardial injection of an adenovirus carrying a reporter gene resulted in diffuse expression and in substantial spillover to the liver, spleen and lungs. Transient expression of TBX18 mRNA in rats led to de novo automaticity and pacemaker properties and, compared with the injection of adenovirus, to substantial reductions in the expression of inflammatory genes and in activated macrophage populations. In rodent and clinically relevant porcine models of complete heart block, intramyocardially injected TBX18 mRNA provided rate-adaptive cardiac pacing for one month that strongly correlated with the animal’s sinus rhythm and physical activity. TBX18 mRNA may aid the development of biological pacemakers.
Decreasing the blood flow of non-compressible intra-abdominal organs with non-invasive transcutaneous electrical stimulation
Authors: Cakmak Yusuf O. , Khwaounjoo Prashanna , Pangilinan Joseph , Wise Innes K. , Burrows Chris , Kolakshyapati Pranish , Williams Zoe , Bannon Paul 
Published: May 2024

AbstractNon-invasive neuromodulation of non-compressible internal organs has significant potential for internal organ bleeding and blood-shift in aero/space medicine. The present study aims to investigate the potential influences of the non-invasive transcutaneous electrical nerve stimulation (TENS) on multiple non-compressible internal organs’ blood flow. Porcine animal model (n = 8) was randomized for a total of 48 neuromodulation sessions with two different TENS stimulation frequencies (80 Hz, 10 Hz) and a placebo stimulation. A combination of two different electrode configurations (Abdominal-only or Abdominal and hind limb) were also performed. Intraarterial blood flow measurements were taken during pre and post-stimulation periods at the left renal artery, common hepatic artery, and left coronary artery. Intracranial, and extracranial arterial blood flows were also assessed with digital subtraction angiography. TENS with abdominal-only electrode configurations at 10 Hz demonstrated significant reductions in average peak blood flow velocity (APV) of the common hepatic artery (p = 0.0233) and renal arteries (p = 0.0493). Arterial pressures (p = 0.0221) were also significantly lower when renal APV was reduced. The outcome of the present study emphasises the potential use of TENS in decreasing the blood flow of non-compressible internal organs when the correct combination of electrodes configuration and frequency is used.
Investigation of high-dose radiotherapy's effect on brain structure aggravated cognitive impairment and deteriorated patient psychological status in brain tumor treatment
Authors: Ma Jianpeng , Cao Hetao , Hou Dongmei , Wang Weiqi , Liu Tingting 
Published: May 2024

AbstractThis study aims to investigate the potential impact of high-dose radiotherapy (RT) on brain structure, cognitive impairment, and the psychological status of patients undergoing brain tumor treatment. We recruited and grouped 144 RT-treated patients with brain tumors into the Low dose group (N = 72) and the High dose group (N = 72) according to the RT dose applied. Patient data were collected by using the HADS and QLQ-BN20 system for subsequent analysis and comparison. Our analysis showed no significant correlation between the RT doses and the clinicopathological characteristics. We found that a high dose of RT could aggravate cognitive impairment and deteriorate patient role functioning, indicated by a higher MMSE and worsened role functioning in the High dose group. However, the depression status, social functioning, and global health status were comparable between the High dose group and the Low dose group at Month 0 and Month 1, while being worsened in the High dose group at Month 3, indicating the potential long-term deterioration of depression status in brain tumor patients induced by high-dose RT. By comparing patient data at Month 0, Month 1, Month 3, Month 6, and Month 9 after RT, we found that during RT treatment, RT at a high dose could aggravate cognitive impairment in the short term and lead to worsened patient role functioning, and even deteriorate the overall psychological health status of patients in the long term.
Floating body effect in indium–gallium–zinc–oxide (IGZO) thin-film transistor (TFT)
Authors: Park Jingyu , Go Seungwon , Chae Woojun , Ryoo Chang Il , Kim Changwook , Noh Hyungju , Kim Seonggeun , Du Ahn Byung , Cho In-Tak , Yun Pil Sang , Bae Jong Uk , Park Yoo Seok , Kim Sangwan , Kim Dae Hwan 
Published: May 2024

AbstractIn this paper, the floating body effect (FBE) in indium-gallium-zinc-oxide (IGZO) thin-film transistor (TFT) and the mechanism of device failure caused by that are reported for the first time. If the toggle AC pulses are applied to the gate and drain simultaneously for the switching operation, the drain current of IGZO TFT increases dramatically and cannot show the on/off switching characteristics. This phenomenon was not reported before, and our study reveals that the main cause is the formation of a conductive path between the source and drain: short failure. It is attributed in part to the donor creation at the drain region during the high voltage (Vhigh) condition and in part to the donor creation at the source region during the falling edge and low voltage (Vlow) conditions. Donor creation is attributed to the peroxide formation in the IGZO layer induced by the electrons under the high lateral field. Because the donor creation features positive charges, it lowers the threshold voltage of IGZO TFT. In detail, during the Vhigh condition, the donor creation is generated by accumulated electrons with a high lateral field at the drain region. On the other hand, the floating electrons remaining at the short falling edge (i.e., FBE of the IGZO TFT) are affected by the high lateral field at the source region during the Vlow condition. As a result, the donor creation is generated at the source region. Therefore, the short failure occurs because the donor creations are generated and expanded to channel from the drain and source region as the AC stress accumulates. In summary, the FBE in IGZO TFT is reported, and its effect on the electrical characteristics of IGZO TFT (i.e., the short failure) is rigorously analyzed for the first time.
Design of high-performance entangling logic in silicon quantum dot systems with Bayesian optimization
Authors: Kang Ji-Hoon , Yoon Taehyun , Lee Chanhui , Lim Sungbin , Ryu Hoon 
Published: May 2024

AbstractDevice engineering based on computer-aided simulations is essential to make silicon (Si) quantum bits (qubits) be competitive to commercial platforms based on superconductors and trapped ions. Combining device simulations with the Bayesian optimization (BO), here we propose a systematic design approach that is quite useful to procure fast and precise entangling operations of qubits encoded to electron spins in electrode-driven Si quantum dot (QD) systems. For a target problem of the controlled-X (CNOT) logic operation, we employ BO with the Gaussian process regression to evolve design factors of a Si double QD system to the ones that are optimal in terms of speed and fidelity of a CNOT logic driven by a single microwave pulse. The design framework not only clearly contributes to cost-efficient securing of solutions that enhance performance of the target quantum operation, but can be extended to implement more complicated logics with Si QD structures in experimentally unprecedented ways.
Short-term photovoltaic energy generation for solar powered high efficiency irrigation systems using LSTM with Spatio-temporal attention mechanism
Authors: Awais Muhammad , Mahum Rabbia , Zhang Hao , Zhang Wei , M. Metwally Ahmed Sayed , Hu Jiandong , Arshad Ifzan 
Published: May 2024

AbstractSolar irrigation systems should become more practical and efficient as technology advances. Automation and AI-based technologies can optimize solar energy use for irrigation while reducing environmental impacts and costs. These innovations have the potential to make agriculture more environmentally friendly and sustainable. Solar irrigation system implementation can be hampered by a lack of technical expertise in installation, operation, and maintenance. It must be technically and economically feasible to be practical and continuous. Due to weather and solar irradiation, photovoltaic power generation is difficult for high-efficiency irrigation systems. As a result, more precise photovoltaic output calculations could improve solar power systems. Customers should benefit from increased power plant versatility and high-quality electricity. As a result, an artificial intelligence-powered automated irrigation power-generation system may improve the existing efficiency. To predict high-efficiency irrigation system power outputs, this study proposed a spatial and temporal attention block-based long-short-term memory (LSTM) model. Using MSE, RMSE, and MAE, the results have been compared to pre-existing ML and a simple LSTM network. Moreover, it has been found that our model outperformed cutting-edge methods. MAPE was improved by 6–7% by increasing Look Back (LB) and Look Forward (LF). Future goals include adapting the technology for wind power production and improving the proposed model to harness customer behavior to improve forecasting accuracy.
Chemical composition and biological activities of essential oils of seven Cultivated Apiaceae species
Authors: Önder Sercan , Periz Çağdaş Deniz , Ulusoy Seyhan , Erbaş Sabri , Önder Damla , Tonguç Muhammet 
Published: May 2024

AbstractThe Apiaceae family contains many species used as food, spice and medicinal purposes. Different parts of plants including seeds could be used to obtain essential (EO) oils from members of the Apiaceae family. In the present study, EOs were components obtained through hydrodistillation from the seeds of anise (Pimpinella anisum), carrot (Daucus carota), celery (Apium graveolens), dill (Anethum graveolens), coriander (Coriandrum sativum), fennel (Foeniculum vulgare), and cumin (Cuminum cyminum). EO constituents were determined with Gas Chromatography/Mass Spectrometry (GC–MS) and Gas Chromatography/Flame Ionization Detector (GC-FID) and their antioxidant capacities were determined with the cupric reducing antioxidant capacity (CUPRAC) and 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) methods. The antimicrobial activity of EOs were tested against four pathogenic bacteria. Phenylpropanoids in anise (94.87%) and fennel (92.52%), oxygenated monoterpenes in dill (67.59%) and coriander (98.96%), monoterpene hydrocarbons in celery (75.42%), mono- (45.42%) and sesquiterpene- (43.25%) hydrocarbons in carrots, monoterpene hydrocarbon (34.30%) and aromatic hydrocarbons (32.92%) in cumin were the major compounds in the EOs. Anethole in anise and fennel, carotol in carrot, limonene in celery, carvone in dill, linalool in coriander, and cumin aldehyde in cumin were predominant compounds in these EOs. The high hydrocarbon content in cumin EO gave high CUPRAC activity (89.07 µmol Trolox g−1), and the moderate monoterpene hydrocarbon and oxygenated monoterpene content in dill EO resulted in higher DPPH activity (9.86 µmol Trolox g−1). The in vitro antibacterial activity of EOs against Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli was evaluated using the agar diffusion method and the minimum bactericidal concentration was determined. Coriander, cumin and dill EOs showed inhibitory effect against all tested strains except P. aeruginosa. While fennel and celery EOs were effective against E. coli and B. cereus strains, respectively, anise and carrot EOs did not show any antibacterial effect against the tested bacteria. Hierarchical Cluster Analysis (HCA) produced four groups based on EO constituents of seven species. The potential adoption of the cultivated Apiaceae species for EO extraction could be beneficial for the wild species that are endangered by over collection and consumption.
Serum exosomes miR-206 and miR-549a-3p as potential biomarkers of traumatic brain injury
Authors: Yang Yajun , Wang Yi , Li Panpan , Bai Feirong , Liu Cai , Huang Xintao 
Published: May 2024

AbstractTraumatic brain injury (TBI) is one of the leading causes of death and disability worldwide. However, effective diagnostic, therapeutic and prognostic biomarkers are still lacking. Our research group previously revealed through high-throughput sequencing that the serum exosomes miR-133a-3p, miR-206, and miR-549a-3p differ significantly in severe TBI (sTBI), mild or moderate TBI (mTBI), and control groups. However, convincing experimental evidence is lacking. To solve this problem, we used qPCR in this study to further verify the expression levels of serum exosomes miR-133a-3p, miR-206 and miR-549a-3p in TBI patients. The results showed that the serum exosomes miR-206 and miR-549a-3p showed good predictive value as biomarkers of TBI. In addition, in order to further verify whether serum exosomes miR-206 and miR-549a-3p can be used as potential biomarkers in patients with TBI and to understand the mechanism of their possible effects, we further determined the contents of SOD, BDNF, VEGF, VEGI, NSE and S100β in the serum of TBI patients. The results showed that, serum exosomes miR-206 and miR-549a-3p showed good correlation with BDNF, NSE and S100β. In conclusion, serum exosomes miR-206 and miR-549a-3p have the potential to serve as potential biomarkers in patients with TBI.
Magnetic integrated double-trap filter utilizing the mutual inductance for reducing current harmonics in high-speed railway traction inverters
Authors: Al-Barashi Maged , Wang Yongjun , Lan Bin , Bhutta Muhammad Shoaib 
Published: May 2024

AbstractCurrent harmonics are generated at the switching frequency and its multiples when the traction converters are modulated. To address this, multi-trap filters are introduced, which are capable of selectively eliminating these specific harmonics to the limits set by IEEE 519-2014. This targeted removal significantly reduces the need for high total inductance, thereby allowing for a more compact filter design. Comparatively, to traditional inductor-capacitor-inductor (LCL) filters, more magnetic cores are needed for trap inductors. Furthermore, the traction systems have not been examined in conjunction with multi-trap filters. To reduce the filter size and investigate its application in traction converters, this paper presents an integrated double-trap LCL (DTLCL) filter. A tiny capacitor is connected in parallel with the grid-side inductor to form one LC-trap. In addition, another LC-trap is formed by connecting the equivalent trap inductor, introduced through the magnetic coupling between inverter-side and grid-side inductors, in series with the filter capacitor. The presented filters' features are thoroughly analyzed, and the design method has been developed. Finally, the simulation and hardware-in-the-loop (HIL) experiment results validate the proposed method's viability and efficacy. Compared to the discrete windings, the integrated ones enable a size decrease of two cores. Furthermore, the proposed filters can meet IEEE 519-2014 criteria with 0.3% for all the current switching harmonics and total harmonic distortion (THD) of 2.36% of the grid‐side current.
Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
Authors: Wang Hu , Wang Jiaxing , Cui Hao , Fan Chenyu , Xue Yuzhou , Liu Huiying , Li Hui , Li Jianping , Li Houhua , Sun Ying , Wang Wengong , Song Jiangping , Jiang Changtao , Xu Ming 
Published: May 2024

AbstractDiabetic cardiomyopathy is characterized by myocardial lipid accumulation and cardiac dysfunction. Bile acid metabolism is known to play a crucial role in cardiovascular and metabolic diseases. Takeda G-protein-coupled receptor 5 (TGR5), a major bile acid receptor, has been implicated in metabolic regulation and myocardial protection. However, the precise involvement of the bile acid–TGR5 pathway in maintaining cardiometabolic homeostasis remains unclear. Here we show decreased plasma bile acid levels in both male and female participants with diabetic myocardial injury. Additionally, we observe increased myocardial lipid accumulation and cardiac dysfunction in cardiomyocyte-specific TGR5-deleted mice (both male and female) subjected to a high-fat diet and streptozotocin treatment or bred on the diabetic db/db genetic background. Further investigation reveals that TGR5 deletion enhances cardiac fatty acid uptake, resulting in lipid accumulation. Mechanistically, TGR5 deletion promotes localization of CD36 on the plasma membrane through the upregulation of CD36 palmitoylation mediated by the palmitoyl acyltransferase DHHC4. Our findings indicate that the TGR5–DHHC4 pathway regulates cardiac fatty acid uptake, which highlights the therapeutic potential of targeting TGR5 in the management of diabetic cardiomyopathy.
Human macrophages infected with Egyptian Rousette bat-isolated Marburg virus display inter-individual susceptibility and antiviral responsiveness
Authors: Yordanova Ivet A. , Lander Angelika , Wahlbrink Annette , Towner Jonathan S. , Albariño César G. , Ang Lay Teng , Prescott Joseph B. 
Published: May 2024

AbstractMarburg virus (MARV) is a highly pathogenic filovirus and a causative agent of sporadic zoonotic viral hemorrhagic fever outbreaks with high case fatality rates. In humans, filoviruses like MARV and Zaire Ebola virus (EBOV) target, among others, innate immune cells like dendritic cells and macrophages (MΦs). Filovirus-infected dendritic cells display impaired maturation and antigen presentation, while MΦs become hyper-activated and secrete proinflammatory cytokines and chemokines. Our current understanding of human macrophage responses to MARV remains limited. Here, we used human monocyte-derived macrophages (moMΦs) to address how their phenotype, transcriptional profile, and protein expression change upon an in vitro infection with a bat isolate of MARV. Confirming its tropism for macrophages, we show that MARV induces notable shifts in their transcription distinct from responses induced by lipopolysaccharide (LPS), marked by upregulated gene expression of several chemokines, type I interferons, and IFN-stimulated genes. MARV infection also elicited pronounced inter-individually different transcriptional programs in moMΦs, the induction of Wnt signaling-associated genes, and the downregulation of multiple biological processes and molecular pathways.