bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Reactions of Nitroxides. Part 12. 2,2,6,6‐Tetramethyl‐1‐oxyl‐4‐piperidyl Chloroformate — A New Reactive Nitroxyl Radical. A One‐Pot Synthesis of 2,2,6,6‐Tetramethyl‐1‐oxyl‐4‐piperidyl N,N‐Dialkyl‐carbamates.
Authors: Zakrzewski Jerzy , Krawczyk Maria 
Published: September 2011

AbstractA series of 10 nitroxide derivatives of type (V) is prepared via the chloroformates or chlorothioformates (III).
ChemInform Abstract: Ruthenium‐Catalyzed Conversion of sp3 C—O Bonds in Ethers to C—C Bonds Using Triarylboroxines.
Authors: Ogiwara Yohei , Kochi Takuya , Kakiuchi Fumitoshi 
Published: September 2011

AbstractThe reaction is applied to alkyl ethers bearing 2‐ or 4‐pyridyl groups and various triarylboroxines.
ChemInform Abstract: N‐(2‐Aminobenzoyl)‐N‐methylhydrazones of Aldehydes and Aldoses and Their Cyclization to Benzo‐1,3,4‐triazepine Derivatives.
Authors: Ershov A. Yu. , Chernitsa B. V. , Doroshenko V. A. , Yakimovich S. I. , Alekseyev V. V. , Lagoda I. V. , Pakal'nis V. V. , Zerova I. V. , Shamanin V. V. 
Published: September 2011

AbstractCondensation products of title hydrazone with aliphatic and aromatic aldehydes as well as aldoses are synthesized.
ChemInform Abstract: Asymmetric Synthesis of α‐Alkyl α‐Selenocarbonyl Compounds Catalyzed by Bifunctional Organocatalysts.
Authors: Marcos Vanesa , Aleman Jose , Garcia Ruano Jose L. , Marini Francesca , Tiecco Marcello 
Published: September 2011

AbstractA wide scope of arylsubstituted nitroalkenes can be converted with good yields.
ChemInform Abstract: New Monoterpene Glycosides and Phenolic Compounds from Distylium racemosum and Their Inhibitory Activity Against Ribonuclease H.
Authors: Kim Jeong Ah , Yang Seo Young , Wamiru Anthony , McMahon James B. , Le Grice Stuart F. J. , Beutler John A. , Kim Young Ho 
Published: September 2011

AbstractThe novel monoterpene glycosides distyloside A (I) and B (II) and the new megastigmane glucoside iso‐dihydrodendranthemoside A (III) are isolated from twigs and leaves of Distylium racemosum together with five known phenolic compounds.
ChemInform Abstract: Antiplasmodial and Antitumor Activity of Dihydroartemisinin Analogues Derived via the Aza‐Michael Addition Reaction.
Authors: Feng Tzu‐Shean , Guantai Eric M. , Nell Margo J. , van Rensburg Constance E. J. , Hoppe Heinrich C. , Chibale Kelly 
Published: September 2011

AbstractThe aza‐Michael reaction of 10α‐ and 10β‐dihydroartemisinin acrylates, respectively with amines and chloroquinoline amines gives access to novel artemisinin analogues (I) and (II) whose antiplasmodial and antitumor activity is evaluated.
ChemInform Abstract: Cyclopropenium Cation Promoted Dehydrative Glycosylations Using 2‐Deoxy‐ and 2,6‐Dideoxy‐Sugar Donors.
Authors: Nogueira Jason M. , Nguyen Son Hong , Bennett Clay S. 
Published: September 2011

Abstractα‐Selectivity is observed for both donors (I) and (VIII).
ChemInform Abstract: Synthesis and Biological Evaluation of Novel 7‐Acyl Homocamptothecins as Toposiomerase I Inhibitors.
Authors: Zhang Wannian , et al. et al. 
Published: September 2011

AbstractA series of novel 7‐substituted homocamptothecin derivatives are synthesized using the reaction of 10‐methoxyhomocamptothecin (III) with aldehydes under Minisci free‐radical reaction conditions.
ChemInform Abstract: Three‐Step Synthesis of Ethyl Canthinone‐3‐carboxylates from Ethyl 4‐Bromo‐6‐methoxy‐1,5‐naphthyridine‐3‐carboxylate via a Pd‐Catalyzed Suzuki—Miyaura Coupling and a Cu‐Catalyzed Amidation Reaction.
Authors: Ioannidou Heraklidia A. , Martin Aaron , Gollner Andreas , Koutentis Panayiotis A. 
Published: September 2011

AbstractThe aza analogues (IX) are also available.
ChemInform Abstract: 4β‐[(4‐Alkyl)‐1,2,3‐triazol‐1‐yl] Podophyllotoxins as Anticancer Compounds: Design, Synthesis and Biological Evaluation.
Authors: Reddy Doma Mahendhar , Srinivas Jada , Chashoo Gousia , Saxena Ajit K. , Kumar H. M. Sampath 
Published: September 2011

AbstractThe title compounds (III) are evaluated for their cytotoxicity against the human cancer cell lines SF‐295, A‐549, PC‐3, Hep‐2, HCT‐15 and MCF‐7.
Optimization of Production Systems Using Material Flow Networks
Authors: Lambrecht Hendrik 
Published: September 2011

AbstractStoffstromnetzbasierte Softwaretools werden heute von zahlreichen Unternehmen eingesetzt, um komplexe Produktionssysteme zu analysieren und zu verbessern. Stoffstromnetze sind eine spezielle Technik der Stoffstromanalyse, deren intuitiver Modellierungsansatz die Identifizierung von Optimierungspotenzialen begünstigt. Eine automatische Modelloptimierung ist dagegen bislang nicht möglich. Hier werden der Prototyp eines stoffstromnetzbasierten Optimierungswerkzeugs sowie numerische Ergebnisse zur Konvergenzgeschwindigkeit der implementierten Optimierungsalgorithmen vorgestellt. Durch die Anwendung des Optimierungswerkzeugs auf ein Planungsproblem aus der Abfallwirtschaft werden die Vorteile einer Integration von Stoffstromanalyse und Optimierung illustriert.
CO2‐Triggered Metal Catalyst‐ and Solvent‐free Aminochlorination of Methylenecyclopropanes
Authors: Qi Minghui , Shao Lixiong , Shi Min 
Published: September 2011

AbstractAminochlorination of methylenecyclopropanes (MCPs) 1 can be achieved under CO2 atmosphere using N,N‐dichlorotoluenesulfonamine (TsNCl2) as the nitrogen and halogen sources at room temperature to give the corresponding normal ring‐remaining aminochlorinated products 2 along with/without the ring‐opened aminochlorinated products 3 in moderate to good total yields. The present process takes the advantage of the green benign reaction conditions in the absence of any metal catalyst and solvent.
Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids
Authors: Biswas Souvik , Knipp Ralph J. , Gordon Laura E. , Nandula Seshagiri R. , Gorr Sven‐Ulrik , Clark Geoffrey J. , Nantz Michael H. 
Published: September 2011

AbstractThe manipulation of the cationic lipid structures to increase polynucleotide binding and delivery properties, while also minimizing associated cytotoxicity, has been a principal strategy for developing next‐generation transfection agents. The polar (DNA binding) and hydrophobic domains of transfection lipids have been extensively studied; however, the linking domain comprising the substructure used to tether the polar and hydrophobic domains has attracted considerably less attention as an optimization variable. Here, we examine the use of an oxime ether as the linking domain. Hydrophobic oxime ethers were readily assembled via click chemistry by oximation of hydrophobic aldehydes using an aminooxy salt. A facile ligation reaction delivered the desired compounds with hydrophobic domain asymmetry. Using the MCF‐7 breast cancer, H1792 lung cancer and PAR C10 salivary epithelial cell lines, our findings show that lipoplexes derived from oxime ether lipids transfect in the presence of serum at higher levels than commonly used liposome formulations, based on both luciferase and green fluorescent protein (GFP) assays. Given the biological compatibility of oxime ethers and their ease of formation, this functional group should find significant application as a linking domain in future designs of transfection vectors.
Molecular classification of nonsmall cell lung cancer using a 4‐protein quantitative assay
Authors: Anagnostou Valsamo K. , Dimou Anastasios T. , Botsis Taxiarchis , Killiam Elizabeth J. , Gustavson Mark D. , Homer Robert J. , Boffa Daniel , Zolota Vassiliki , Dougenis Dimitrios , Tanoue Lynn , Gettinger Scott N. , Detterbeck Frank C. , Syrigos Konstantinos N. , Bepler Gerold , Rimm David L. 
Published: September 2011

AbstractBACKGROUND:The importance of definitive histological subclassification has increased as drug trials have shown benefit associated with histology in nonsmall‐cell lung cancer (NSCLC). The acuity of this problem is further exacerbated by the use of minimally invasive cytology samples. Here we describe the development and validation of a 4‐protein classifier that differentiates primary lung adenocarcinomas (AC) from squamous cell carcinomas (SCC).METHODS:Quantitative immunofluorescence (AQUA) was employed to measure proteins differentially expressed between AC and SCC followed by logistic regression analysis. An objective 4‐protein classifier was generated to define likelihood of AC in a training set of 343 patients followed by validation in 2 independent cohorts (n = 197 and n = 235). The assay was then tested on 11 cytology specimens.RESULTS:Statistical modeling selected thyroid transcription factor 1 (TTF1), CK5, CK13, and epidermal growth factor receptor (EGFR) to generate a weighted classifier and to identify the optimal cutpoint for differentiating AC from SCC. Using the pathologist's final diagnosis as the criterion standard, the molecular test showed a sensitivity of 96% and specificity of 93%. Blinded analysis of the validation sets yielded sensitivity and specificity of 96% and 97%, respectively. Our assay classified the cytology specimens with a specificity of 100% and sensitivity of 87.5%.CONCLUSIONS:Molecular classification of NSCLC using an objective quantitative test can be highly accurate and could be translated into a diagnostic platform for broad clinical application. Cancer 2011;. © 2011 American Cancer Society.
Pretreatment fertility counseling and fertility preservation improve quality of life in reproductive age women with cancer
Authors: Letourneau Joseph M. , Ebbel Erin E. , Katz Patricia P. , Katz Audra , Ai Wei Z. , Chien A. Jo , Melisko Michelle E. , Cedars Marcelle I. , Rosen Mitchell P. 
Published: September 2011

AbstractBACKGROUND:The post‐treatment quality of life (QOL) impacts of receiving precancer‐treatment infertility counseling and of pursuing fertility preservation have not been described in large‐scale studies of reproductive age women with cancer.METHODS:In total, 1041 women who were diagnosed between ages 18 and 40 years responded to a retrospective survey and reported whether they received infertility counseling before cancer treatment and whether they took action to preserve fertility. Five cancer types were included: leukemia, Hodgkin disease, non‐Hodgkin lymphoma, breast cancer, and gastrointestinal cancer. Validated QOL scales were used: the Decision Regret Score, the Satisfaction with Life Scale (SWLS), and the brief World Health Organization QOL questionnaire.RESULTS:Overall, 560 women (61%) who received treatment that potentially could affect fertility were counseled by the oncology team, 45 (5%) were counseled by fertility specialists, and 36 (4%) took action to preserve fertility. Pretreatment infertility counseling by a fertility specialist and an oncologist resulted in lower regret than counseling by an oncologist alone (8.4 vs 11.0; P < .0001). The addition of fertility preservation (6.6 vs 11.0; P < .0001) also was associated with even lower regret scores than counseling by an oncologist alone. Further improvements also were observed in SWLS scores with the addition of fertility specialist counseling (23.0 vs 19.8; P = .09) or preserving fertility (24.0 vs 19.0; P = .05).CONCLUSIONS:Receiving specialized counseling about reproductive loss and pursuing fertility preservation is associated with less regret and greater QOL for survivors, yet few patients are exposed to this potential benefit. Women of reproductive age should have expert counseling and should be given the opportunity to make active decisions about preserving fertility. Cancer 2011;. © 2011 American Cancer Society.
Stereotactic body radiotherapy using a radiobiology‐based regimen for stage I nonsmall cell lung cancer
Authors: Shibamoto Yuta , Hashizume Chisa , Baba Fumiya , Ayakawa Shiho , Manabe Yoshihiko , Nagai Aiko , Miyakawa Akifumi , Murai Taro , Iwata, Hiromitsu , Mori Yoshimasa , Mimura Mikio , Ishikura Satoshi 
Published: September 2011

AbstractBACKGROUND:The most common regimen of stereotactic body radiotherapy (SBRT) for stage I nonsmall cell lung cancer in Japan is 48 grays (Gy) in 4 fractions over 4 days. Radiobiologically, however, higher doses are necessary to control larger tumors, and interfraction intervals should be >24 hours to take advantage of reoxygenation. In this study, the authors tested the following regimen: For tumors that measured <1.5 cm, 1.5 to 3.0 cm, and >3.0 cm in greatest dimension, radiation doses of 44 Gy, 48 Gy, and 52 Gy, respectively, were given in 4 fractions with interfraction intervals of ≥3 days.METHODS:Among 180 patients with histologically proven disease who entered the study, 120 were medically inoperable, and 60 were operable. The median patient age was 77 years (range, 29‐92 years). SBRT was performed with 6‐megavolt photons using 4 noncoplanar beams and 3 coplanar beams. Isocenter doses of 44 Gy, 48 Gy, and 52 Gy were received by 4 patients, 124 patients, and 52 patients, respectively.RESULTS:The overall survival rate for all 180 patients was 69% at 3 years and 52% at 5 years. The 3‐year survival rate was 74% for operable patients and 59% for medically inoperable patients (P = .080). The 3‐year local control rate was 86% for tumors ≤3 cm (44/48 Gy) and 73% for tumors >3 cm (52 Gy; P = .050). Grade ≥2 radiation pneumonitis developed in 13% of patients (10% of the 44‐Gy/48‐Gy group and 21% of the 52‐Gy group; P = .056). All other grade 2 toxicities developed in <4% of patients.CONCLUSIONS:The SBRT protocol used in this study yielded reasonable local control and overall survival rates and acceptable toxicity. Dose escalation is being investigated. Cancer 2012;. © 2011 American Cancer Society.
Cancer‐testis antigens expressed in osteosarcoma identified by gene microarray correlate with a poor patient prognosis
Authors: Zou Changye , Shen Jingnan , Tang Qinglian , Yang Zheng , Yin Junqiang , Li Zhibin , Xie Xianbiao , Huang Gang , Lev Dina , Wang Jin 
Published: September 2011

AbstractBACKGROUND:From 30% to 40% patients with osteosarcoma eventually experience medical failure; and few biomarkers of prognostic significance have been established. High‐throughput methods like gene microarray analysis can help to identify molecular biomarkers that are useful for diagnosing osteosarcoma and targeting its treatment.METHODS:Oligonucleotide microarrays were used to compare expression profiles of osteosarcoma cell lines and osteoblasts. Differentially expressed genes were confirmed by real‐time polymerase chain reaction (PCR) analysis. Corresponding proteins were evaluated by flow cytometry and Western blot analysis in osteosarcoma cell lines and by immunohistochemistry in osteosarcoma tissues. The association between staining intensity and clinical outcome was analyzed further.RESULTS:Cancer‐testis antigens, including melanoma antigen family A (MAGEA), chondrosarcoma‐associated gene family, member 2 (CSAG2), and preferentially expressed antigen in melanoma (PRAME), were increased significantly in all osteosarcoma cell lines that were analyzed. Real‐time PCR examinations indicated that cancer‐testis antigen expression was frequent and coordinated in patients with osteosarcoma. The expression of MAGEA was confirmed by Western blot and flow cytometry analyses in osteosarcoma cell lines. Furthermore, immunohistochemical staining analysis suggested that MAGEA expression may be used to predict distant metastasis and poor survival. The adjusted relative risk for lung metastasis was 2.79 (95% confidence interval, 1.12‐6.93; P = .028) for MAGEA‐positive patients. Five‐year survival rates for patients with and without MAGEA expression were 39.6% ± 8.4% and 80% ± 8.9%, respectively (log‐rank test; P = .01).CONCLUSIONS:The combined use of an oligonucleotide microarray, a clinical database, and a tissue bank was useful for identifying molecular tumor markers. The frequent expression of MAGEA and other cancer‐testis antigens in osteosarcoma indicates that they may be useful as diagnostic markers and targets of immunotherapy that warrant further investigation. Cancer 2012. © 2011 American Cancer Society.
Optical fiber‐based in vivo quantification of growth factor receptors
Authors: Thomas Thommey P. , Chang Yu‐Chung , Ye Jing Yong , Kotlyar Alina , Cao Zhengyi , Shukla Rameshwer , Qin Suyang , Norris Theodore B. , Baker James R. 
Published: September 2011

AbstractBACKGROUND:Growth factor receptors such as epidermal growth factor receptor 1 and human epidermal growth receptor 2 (HER2) are overexpressed in certain cancer cells. Antibodies against these receptors (eg. cetuximab and transtuzumab [Herceptin]) have shown therapeutic value in cancer treatment. The existing methods for the quantification of these receptors in tumors involve immunohistochemistry or DNA quantification, both in extracted tissue samples. The goal of the study was to evaluate whether an optical fiber‐based technique can be used to quantify the expression of multiple growth factor receptors simultaneously.METHODS:The authors examined HER2 expression using the monoclonal antibody trastuzumab as a targeting ligand to test their system. They conjugated trastuzumab to 2 different Alexa Fluor dyes with different excitation and emission wavelengths. Two of the dye conjugates were subsequently injected intravenously into mice bearing HER2‐expressing subcutaneous tumors. An optical fiber was then inserted into the tumor through a 30‐gauge needle, and using a single laser beam as the excitation source, the fluorescence emitted by the 2 conjugates was identified and quantified by 2‐photon optical fiber fluorescence.RESULTS:The 2 conjugates bound to the HER2‐expressing tumor competitively in a receptor‐specific fashion, but they failed to bind to a similar cell tumor that did not express HER2. The concentration of the conjugate present in the tumor as determined by 2‐photon optical fiber fluorescence was shown to serve as an index of the HER2 expression levels.CONCLUSIONS:These studies offer a minimally invasive technique for the quantification of tumor receptors simultaneously. Cancer 2012;. © 2011 American Cancer Society.
The association of the BRAFV600E mutation with prognostic factors and poor clinical outcome in papillary thyroid cancer
Authors: Kim Tae Hyuk , Park Young Joo , Lim Jung Ah , Ahn Hwa Young , Lee Eun Kyung , Lee You Jin , Kim Kyung Won , Hahn Seo Kyung , Youn Yeo Kyu , Kim Kwang Hyun , Cho Bo Youn , Park Do Joon 
Published: September 2011

AbstractBACKGROUND:The effects of the BRAFV600E mutation on prognostic factors and poor clinical outcomes in papillary thyroid cancer (PTC) have not been fully quantified. The authors performed comprehensive meta‐analysis to assess the strength of associations between these conditions and the BRAFV600E mutation.METHODS:The authors identified the clinical studies that examined the association of the BRAFV600E mutation in surgical specimens with clinicopathologic outcomes between January 2003 and October 2010 using the Medline database. One hundred thirty‐one relevant studies were hand‐searched. The authors selected 27 studies that included 5655 PTC patients. They calculated the pooled odds ratios (ORs) or risk ratios with 95% confidence intervals (CIs) for each study using a random effect model.RESULTS:The average prevalence rate of the BRAFV600E mutation was 49.4%. In 26 studies, compared with the patients who had the wild‐type BRAF genes, the PTC patients with the BRAFV600E mutation had increased ORs of an extrathyroidal invasion (OR, 2.14; 95% CI, 1.68‐2.73), a lymph node metastasis (OR, 1.54; 95% CI, 1.21‐1.97), and an advanced TNM stage (OR, 2.00; 95% CI, 1.61‐2.49). In 8 studies, patients with the mutation had 2.14‐fold increased risk of recurrent and persistent disease (95% CI, 1.67‐2.74). The associations were generally consistent across the different study populations.CONCLUSIONS:This meta‐analysis demonstrates that the BRAFV600E mutation is closely related to the high‐risk clinicopathological factors and poorer outcome of PTC. The results obtained here suggest that the BRAFV600E mutation should be considered as a poor prognostic marker in PTC and may lead to better management for individual patients. Cancer 2012;. © 2011 American Cancer Society.
A meta‐analysis evaluating stereotactic radiosurgery, whole‐brain radiotherapy, or both for patients presenting with a limited number of brain metastases
Authors: Tsao May , Xu Wei , Sahgal Arjun 
Published: September 2011

AbstractBACKGROUND:To perform a meta‐analysis on newly diagnosed brain metastases patients treated with whole‐brain radiotherapy (WBRT) and stereotactic radiosurgery (SRS) boost versus WBRT alone, or in patients treated with SRS alone versus WBRT and SRS boost.METHODS:The meta‐analysis primary outcomes were overall survival (OS), local control (LC), and distant brain control (DBC). Secondary outcomes were neurocognition, quality of life (QOL), and toxicity. Using published Kaplan‐Meier curves, results were pooled using hazard ratios (HR).RESULTS:Two RCTs reported on WBRT and SRS boost versus WBRT alone. For multiple brain metastases (2‐4 tumors) we conclude no difference in OS, and LC significantly favored WBRT plus SRS boost. Three RCTs reported on SRS alone versus WBRT plus SRS boost (1‐4 tumors). There was no difference in OS despite both LC and DBC significantly favoring WBRT plus SRS boost. Although secondary endpoints could not be pooled for meta‐analysis, those RCTs evaluating SRS alone conclude better neurocognition using the validated Hopkins Verbal Learning Test, no adverse risk in deteriorating Mini‐Mental Status Exam scores or in maintaining performance status, and fewer late toxicities. We conclude insufficient data for QOL outcomes.CONCLUSIONS:For selected patients, we conclude no OS benefit for WBRT plus SRS boost compared with SRS alone. Although additional WBRT improves DBC and LC, SRS alone should be considered a routine treatment option due to favorable neurocognitive outcomes, less risk of late side effects, and does not adversely affect the patients performance status. Cancer 2012. © 2011 American Cancer Society.
Theoretical Study of the Photochemistry of a Reversible Three‐State Bis‐Thiaxanthylidene Molecular Switch
Authors: Filatov Michael 
Published: September 2011

AbstractThe ground‐ and the lowest singlet excited‐state potential energy surfaces of the bis‐thiaxanthylidene (3) molecular switch are investigated using a density functional method specifically designed to treat molecular systems typified by strong non‐dynamic electron correlation. The results of the theoretical calculations suggest that the unique ability of substituted bis‐thiaxanthylidenes to switch between three states of luminescence—non‐fluorescent state, blue fluorescent state, and red fluorescent state—can be explained by specific features on the excited state potential energy surface: the potential barrier around the Franck–Condon point of the anti‐folded conformer and the existence of conical intersection in the vicinity of the syn‐folded conformer. It is suggested that the twisted conformer, if made more stable via chemical modification, should fluoresce in the near‐infrared region (λ≈740–760 nm), thus offering a possibility for a four‐state switching of luminescence in a single‐component molecular system.