bluuebunny/crossref_metadata_2025_split huggingface dataset:
Academic Stress and Attitudes Toward Seeking Professional Psychological Help among Vietnamese students: the mediating role of Emotional Intelligence
Authors: Nguyen-Thi Thanh-Thao , Nguyen Dat Tan , Le Huu Minh , Le Cong Minh , Hua Thuy Doan , Nguyen-Hoang Bao-Nhu , Tran-Chi Vinh-Long , Nguyen-Thi Kieu-Lan 
Published: June 2024

Abstract

Background: Emotional Intelligence is considered a noteworthy concept in the academic environment due to the theoretical significance and practical implications. The objectives of this research were to investigate (1) the correlation between academic stress and emotional intelligence, and (2) the mediating role of attitudes toward seeking professional psychological help.
Methods: An online questionnaire was administered to a random sample of 908 Vietnamese secondary school students from December 2023 to January 2024. Three scales were employed to gather demographic variables and self-reported data, including The Wong and Law Emotional Intelligence Scale, The Educational Stress Scale for Adolescents, and Attitudes Toward Seeking Professional Psychological Help.
Results: The findings indicated substantial differences across many variables, such as gender, grade, and academic performance ranking. The investigation identified substantial significant relationships, including emotional intelligence of others’ emotion appraisal positively affects self-expectation, while self-emotion appraisal negatively influences self-expectation. The analysis determined significant relationships, including others’ emotion appraisal positively affects self-expectation, while self-emotion appraisal negatively influences self-expectation. Use of emotion positively associates with the openness of seeking professional help. Moderation analyses revealed age moderating others’ emotion appraisal and despondency, self-emotion appraisal and the openness of seeking professional help.
Conclusion: Emotional intelligence exerts a substantial influence on both academic stress levels and attitudes toward seeking professional psychological assistance. The results are analysed in accordance with the guidelines for conducting mixed-methods research. Workshops and awareness sessions for educators and students on emotional intelligence can beconducted with the cooperation of all parties concerned because of the endorsement of all stakeholders.
Real-world efficacy of nanoliposomal irinotecan in patients with advanced pancreatic cancer
Authors: Decraecker Marie , Joncour Sophie Le , Aurillac Valérie , Sangnier Maïté , Ducerf Camille , Berroneau Aude , Rouleau Laetitia , Tougeron David , Laplace Christophe , Madau Magali , Dumon Camille , Perrier Herve , Blanc Jean-Frédéric 
Published: June 2024

Abstract

Background.
In the randomized NAPOLI-1 trial, nanoliposomal irinotecan (Nal-Iri) combined with fluorouracil and folinic acid provided considerable survival increase for patients with metastatic pancreatic ductal adenocarcinomas who had received gemcitabine-based therapy. However, patients included in clinical trials often differ from those encountered in practice. A real-world study was required to assess the efficacy and safety of Nal-Iri in patients with poor prognoses for whom quality of life preservation was essential.
Methods.
We conducted an observational, retrospective national multicenter phase 4 study of patients with advanced pancreatic cancers treated using Nal-Iri combined with fluorouracil and folinic acid in clinical practice. Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method. We used a nomogram validated from a concordance index of eight clinicobiological variables to predict OS.
Results
A total of 58 patients with advanced pancreatic adenocarcinomas who received Nal-Iri combined with fluorouracil and folinic acid in three medical centers between March 2020 and September 2022 were included. The median duration of Nal-Iri treatment was 3.6 (range 1.9–8.8) months. The median follow-up time from the start of first-line treatment was 26.2 (16.5–44.8) months. Of all patients, 20.7% received Nal-Iri in a second-line setting, but most (n = 37 patients; 63.8%) received Nal-Iri in a third-line setting. Forty-two patients (72.4%) had previously been treated with irinotecan. The median OS from the time of Nal-Iri initiation was 6.0 (2.6–13.1) months, and the median PFS was 5.8 (3.2–11.4) months. Patients who received Nal-Iri in a second-line setting exhibited significantly better OS than patients who received Nal-Iri in a third-line setting or later (p < 10− 3). Patients who had previously received irinotecan exhibited significantly lower OS compared with patients who were irinotecan-naïve (p < 10− 3).Our nomogram demonstrated excellent prediction of 6-month and 1-year survivals (p < 10 − 3).
Conclusions.
Nal-Iri combined with fluorouracil and folinic acid was particularly effective in second-line settings and irinotecan non-pre-treated patients. The nomogram demonstrated excellent prediction of survival under real-world conditions.
Visual imagination can influence visual perception – towards an experimental paradigm to measure imagination
Authors: Mozhdehfarahbakhsh Azadeh , Hecker Lukas , Joos Ellen , Kornmeier Jürgen 
Published: June 2024

Abstract

During visual imagination a perceptual representation is activated in the absence of sensory input. This is sometimes described as seeing with the mind’s eyes. A number of physiological studies indicate that the brain uses more or less the same neural resources for real visual perception and visual imagination. The intensity of visual imagination is typically assessed with questionnaires, while more objective measures are missing. Aim of the present study was, to test a new experimental paradigm that may allow to objectively quantify imagination. For this we used priming and adaptation effects during observation of ambiguous figures. Our perception of an ambiguous stimulus is unstable and alternates spontaneously between two possible interpretations. If we first observe an unambiguous stimulus variant (the conditioning stimulus), the subsequently presented ambiguous stimulus can either be perceived in the same way as the test stimulus (priming effect) or in the opposite way (adaptation effect) as a function of the conditioning time. We tested for these classical conditioning effects (priming and adaptation) using an ambiguous Necker Cube and Letter /Number stimuli as test stimuli and unambiguous variants thereof as conditioning stimuli. In a second experimental condition, we tested whether the previous imagination of an unambiguous conditioning stimulus variant – instead of its observation – can have similar conditioning effects on the subsequent test stimulus. We found no systematic classical conditioning effect on the group level, neither for the cube stimuli nor for the letter/number stimuli. However, highly significant correlations between effects of Real and Imaginary condition were observed for both stimulus types. The absence of classical condition effects at the group level may be explained by using only one conditioning time, which may fit with individual priming and adaptation constants of some of our participants but not of others. Our strong correlation results indicate that observers with clear classical conditioning effects have about the same type (priming or adaptation) and intensity of imaginary conditioning effects. As a consequence, not only past perceptual experiences but also past imaginations can influence our current percepts. This is further confirmation that the mechanisms underlying perception and imagination are similar. Our post-hoc qualitative observations from three self-defined aphantasic observers makes our paradigm a promising objective measure to identify aphantasia.
The impact of surgery on butterfly gliomas - A real-life study of biopsy vs. surgical resection
Authors: Picarelli Helder , Medeiros Vitor Macedo Brito , Castro Pedro Henrique Fonseca , Carneiro Guilherme Bezerra , Matsumura Bruno Massanori , Cordeiro Augusto Magno Tranquezi , Yamaki Vitor Nagai , Figueiredo Eberval Gadelha , Teixeira Manoel Jacobsen 
Published: June 2024

Abstract

Background
Despite the extent of resection affecting the overall survival of patients with gliomas, cytoreduction in patients with butterfly gliomas (BG) remains controversial. Contemporary studies suggest that wide removal is feasible, but there is a lack of controlled, randomized, multicenter studies on the subject. The aim of this study was to evaluate the impact of safe maximal surgical resection (SMSR) as a primary treatment strategy in patients with BG.
Methods
30 consecutive patients, primarily treated with neurosurgery, were categorized into Group-A when SMSR was equal to or greater than 50% and Group-B when it was less than 50% (biopsy). The groups were studied and compared for clinical, epidemiological, functionality, survival time (ST), and progression-free survival (PFS) characteristics. Results were analyzed by descriptive and inferential statistics.
Results
The most frequent tumors were glioblastoma IDH-wild type, WHO grade 4. Most patients (80%) had KPS < 70%, however, there was no significant worsening of functionality associated with interventions. Wider resection (Group-A) was associated with a better Kaplan-Meier curve and ST (68.35 versus 17.32 weeks, p = 0.014). PFS was also longer in this group (57.70 versus 4.77 weeks, p = 0.012). In multivariate analysis, resections > 50% were associated with reduced risk of recurrence (HR = 0.20, 95% CI 0.06–0.67, p = 0.009). Complication rates and functional decline were similar between groups.
Conclusion
Surgical resections (> 50%) in patients with BG improved ST and PFS without a significant increase in morbidity and dysfunction.
FAP-α is an effective tool to evaluate stroma invasion of lung adenocarcinoma
Authors: Xiong Siping , Fan Huan , Guo Yimin , Sun Ruixiang , Ma Hongmei , Xiang Yali , Zeng Chao 
Published: June 2024

Abstract

The main difficulty in the diagnosis of atypical in situ adenocarcinoma lies in the distinction between true and false stromal invasion. Moreover, how to identify local alveolar wall collapse in situ lung adenocarcinoma and how to identify whether the trapped adenoid structure around scar is an invasion component have become the key points for accurate diagnosis of lung adenocarcinoma. In the present study, we detected 40 cases of lung adenocarcinoma in situ and 40 cases of invasive adenocarcinoma by using immunohistochemical techniques. We found FAP-α had not immunreactivity in the stroma of adenocarcinoma in situ. However, it stained in the stroma of invasive areas in lung adenocarcinoma. FAP-α staining pattern could represent hyperplastic myofibroblast and demonstrated the true invasion of stroma. This study provides strong evidence that FAP-α is an effective tool to evaluate the presence or absence of stroma invasion of lung adenocarcinoma. Our findings will contribute to the accurate diagnosis of lung invasive adenocarcinoma.
Examining the Role of Peace of Mind, Gratitude, and Positive Reappraisal in Predicting Psychological Well-being Among College Students
Authors: Du Wei , Liu Limin 
Published: June 2024

Abstract

This study investigated the relationships between gratitude, positive reappraisal, peace of mind, and psychological well-being among Chinese college students using a cross-sectional design. Participants included 336 undergraduate students from various disciplines, recruited from four universities in mainland China. Self-reported measures assessed gratitude, positive reappraisal, peace of mind, and psychological well-being. Preliminary analyses ensured data quality and addressed potential common method bias. Confirmatory factor analysis supported the hypothesized measurement model, and structural equation modeling revealed significant direct effects of gratitude, positive reappraisal, and peace of mind on well-being. Additionally, gratitude and positive reappraisal demonstrated significant indirect effects on well-being mediated by peace of mind. Measurement invariance testing confirmed that the model operated equivalently across gender groups, supporting the robustness and generalizability of the findings. These results highlight the importance of gratitude, positive reappraisal, and peace of mind in promoting psychological well-being among college students, particularly in high-pressure academic environments.
An exploratory study:Cadonilimab(AK104) and Lenvatinib combined with stereotactic body radiotherapy in the conversion therapy of potentially resectable hepatocellular carcinoma
Authors: Fu Jiajia , 章 金丰 , Liu Dongen , Lin Zhenyu , Liu Hongli , Hu Jianli , Zhang Tao , Tang Jing , Xue Jun 
Published: June 2024

Abstract

Background
Surgery is one of the standard treatments for long-term survival in patients with hepatocellular carcinoma(HCC). However, the majority of HCC patients are initially diagnosed at an advanced stage, less than 30% of patients can undergo curative resection, and the risk of postoperative recurrence is usually more than 50%. Conversion therapy creates the opportunity for radical resection of potentially resectable HCC, but its exact protocol and effectiveness remain controversial. As a first-line systematic treatment for advanced HCC, immunocombined targeted therapy has shown good efficacy. Studies have shown that some patients can obtain surgical resection opportunities through radiotherapy, and radiotherapy combined with immunotherapy has also shown good clinical benefits in conversion therapy trials. Therefore, this study aims to explore the efficacy and safety of Cadonilimab(AK104) and Lenvatinib combined with Stereotactic body radiotherapy(SBRT) in HCC conversion therapy, which may provide a new therapeutic strategy for HCC patients in the future.
Methods/design:
An exploratory clinical study is planned to enroll 27 patients with potentially resectable HCC. Eligible patients underwent tumor evaluation before receiving Cadonilimab(AK104) and Lenvatinib combined with SBRT conversion therapy, after the second cycle of treatment, and before surgery, and were followed up every 6 weeks after surgery. The primary endpoint was objective response rate(ORR), and secondary endpoints were surgical resection rate, major pathological response(MPR), duration of response(DOR), disease control rate(DCR), progression-free survival(PFS), time to disease progression(TTP), and overall survival(OS), and adverse events(AEs).
Discussion
This trial will evaluate the efficacy and safety of Cadonilimab(AK104) and Lenvatinib combined with SBRT in the conversion therapy of potentially resectable HCC patients, providing clinical data for a new mode of conversion therapy for HCC, combining immune and targeted therapy with radiotherapy. At present, there is no consensus standard protocol for HCC conversion therapy, and more prospective studies are needed to further explore the treatment modalities and their effects.
Trial registration:
Chinese Clinical Trial Registry: ChiCTR2300068781, Registered on February 28, 2023.
Sewage digestate compost as a growing medium: implications for manganese uptake in tomato plants
Authors: Aurdal Siv Mari , Bakke Anders , Krogstad Tore , Haraldsen Trond Knapp , Remberg Siv Fagertun 
Published: June 2024

Abstract

Aims
Container-grown crops need reliable growing media that provide optimal conditions for plant growth. The traditional media peat and coconut coir are increasingly being replaced with sustainable alternatives. However, the availability of essential nutrients, such as manganese (Mn), in compost-based media remains a concern. This study therefore aimed to investigate Mn deficiencies in tomato seedlings grown in a compost consisting of 30% v/v sewage digestate and 70% v/v garden waste.
Methods
Tomato plants were cultivated from seeds under nursery conditions for eight weeks. The physical and chemical properties of the growing media, including bulk density, total pore space, air content, water retention, pH, electrical conductivity (EC), and essential nutrients, were assessed. Plant growth parameters such as height, leaf number, chlorophyll content, and fresh/dry weight were measured, alongside nutrient analysis.
Results
Despite the high Mn content in the compost, the tomato plants exhibited significant Mn deficiency. Factors contributing to this deficiency included high pH, abundant organic matter, and elevated iron and calcium levels, which likely formed insoluble compounds, reducing Mn availability. Additionally, the compost's low water retention and structural changes limited plant growth.
Conclusions
The findings emphasize the need to consider Mn availability in compost with a sewage-based component. This study highlights the complexities of nutrient availability in sustainable growing media and the importance of optimizing compost composition to support healthy plant growth.
Bioinformatics Analysis of the Cuprotosis Gene in Immune Infiltration of Chronic Kidney Disease
Authors: Liu Yu , Yang Mengfan , Huang Youqun , Ye Naijing , Zhang Caibin , Luo Yuechan , Zou Hequn 
Published: June 2024

Abstract

Background：Chronic kidney disease is currently a major public health challenge worldwide, and modeling based on gene expression profiling is essential to guide individualized treatment of the disease. According to recent studies, cuprotosis, one of the forms of death of cells, appears to contribute to the progression of various diseases. Therefore, the present study aims to explore clusters associated with cuprotosis genes in chronic kidney disease, delve into immune infiltration, and construct predictive models.
Methods：The GSE37171 (GPL570) dataset was downloaded from the Gene Expression Omnibus for analyzing expression profiling and immune characterization of cuprotosis regulators in CKD. Samples were classified into different clusters based on cuprotosis-related genes (CRGs) of kidney disease. Differential expression pathways and biological functions among clusters were identified through gene set variation analysis. The weighted gene co-expression network analysis algorithm was adopted to identify specific differentially expressed genes of clusters. A machine learning model was built to construct and validate nomogram risk prediction maps.
Results：A total of seven cuprotosis-related genes are differential genes between chronic kidney disease and control group, with differences in immune infiltration between the two groups. Two different clusters are identified based on the expression profiles of the cuprotosis-related genes. And according to the differences in immune infiltration, it is hypothesized that the prognosis of Cluster 2 may be worse. Cluster 1 may be associated with cellular lipid anabolism, fibrosis, signal reception, inflammation, and other processes, while Cluster 2 is more closely related to DNA replication and binding, cellular protein synthesis and transport, peroxisome, etc. The predictive performance of the four selected machine learning classifiers is compared and a prediction model is developed, which provides the highest predictive validity in the test cohort (AUC = 0.992), indicating satisfactory performance. The model is verified to exhibit good predictive efficacy.
Conclusion：The study systematically illustrates the complex relationship between cuprotosis and chronic kidney disease and develops a promising predictive model to assess cuprotosis subtypes in patients with the disease, revealing the underlying molecular mechanisms that lead to its
A single-cell eQTL atlas of the human cerebellum reveals vulnerability of oligodendrocytes in essential tremor
Authors: Rouleau Guy , Castonguay Charles-Etienne , Aboasali Farah , Medeiros Miranda , Becret Theodore , Schmilovich Zoe , Khayachi Anouar , Rajput Alex , Dion Patrick 
Published: June 2024

Abstract

Essential tremor (ET) is a movement disorder characterized by an upper-limb postural and action tremor. It is one of the most common neurological disorders, affecting 1% of the worldwide population. Despite strong evidence for genetic factors driving the aetiology of ET, the underlying pathophysiology remains poorly understood. To understand the effects of genetic risk factors in ET on the cerebellum, the brain region thought to be affected by the disease, we built a population-scale single-cell atlas of the human cerebellar cortex comprised of over 1 million cells from 109 individuals. Using single-cell expression quantitative trait loci and mendelian randomization, we found evidence of ET-associated variants in the BACE2 locus causally linked to its downregulation in cerebellar oligodendrocytes. We highlight a genetically vulnerable population of BACE2-expressing immature oligodendrocytes, suggestive of demyelination. We also find dysfunctional processes affecting interactions between Golgi cells, Purkinje layer interneurons, and oligodendrocytes in ET. Our study suggests a crucial role for cerebellar oligodendrocytes in the pathogenesis of ET.
UW Supplementation with AP39 Improves Liver Viability Following Static Cold Storage
Authors: McLean S Taggart , Holkup Saige , Tchir Alexandra , Mojoudi Mohammadreza , Hassan Madeeha , Taveras Christopher , Ozge S Ozgur , James F Markmann , Yeh Heidi , Uygun Korkut , Longchamp Alban 
Published: June 2024

Abstract

Static cold storage of donor livers at 4°C incompletely arrests metabolism, ultimately leading to decreases in ATP levels, oxidative stress, cell death, and organ failure. Hydrogen Sulfide (H2S) is an endogenously produced gas, previously demonstrated to reduce oxidative stress, reduce ATP depletion, and protect from ischemia and reperfusion injury. H2S is difficult to administer due to its rapid release curve, resulting in cellular death at high concentrations. AP39, a mitochondrially targeted, slow-release H2S donor, has been shown to reduce ischemia-reperfusion injury in hearts and kidneys. Thus, we investigated whether the addition of AP39 during 3-day static cold storage can improve liver graft viability. At the end of storage, livers underwent six hours of acellular normothermic machine perfusion, a model of transplantation. During simulated transplantation, livers stored with AP39 showed reduced resistance, reduced cellular damage (ALT and AST), and reduced apoptosis. Additionally, bile production and glucose, as well as energy charge were improved by the addition of AP39. These results indicate that AP39 supplementation improves liver viability during static cold storage.