bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and radiological aspects of the forearm in children with congenital radioulnar synostosis: a cohort study
Authors: Fedorova Yu. A. , Vissarionov S. V. , Proshchenko Ya. N. , Zorin V. I. 
Published: April 2024

Introduction The upper limb functional limitations in congenital radioulnar synostosis may significantly affect the daily activities of patients. Classifications of the condition are descriptive and have limited practical application.Purpose Determine a functionally significant quantitative criterion for anatomical changes in the forearm.Material and methods 92 children (136 forearms) with congenital radioulnar synostosis were examined for limitations in activities of daily living (ADL), health-related quality of life measured with PedsQL questionnaire; pronation of the forearm and radiographic parameters. A comparative and correlation analysis, ROC analysis were performed to determine the relationship between the forearm pronation and limitations of ADL.Results Statistically significant correlations were revealed between symptoms and the forearm alignment (p < 0.01, rxy = 0.5); subluxation of the ulnar head and forearm alignment (p < 0.001, rxy = 0.6); bowing deformity of the radius, forearm alignment and subluxation of the ulnar head and between the length of the forearm bones and bowing deformity of the radius (p < 0.05, rxy = 0.4 and rxy = 0.5). A statistically significant inverse correlation was revealed between symptoms and PedsQL scores (p = 0.038, rxy = –0.4). Pronation of 45° was the threshold value of the forearm alignment with a high risk of ADL limitation. The area under the ROC curve corresponding to the relationship between symptoms and the forearm alignment was 0.955 ± 0.021 (95 % CI: 0.915–0.995). There was a statistically significant (p < 0.01) decrease in the lumen of the medullary canal in the middle third of the ulnar shaft with the radius lumen being unchanged. Dorsal subluxation of the ulnar head was detected In 30 % of cases.Discussion The characteristics identified demonstrated changes in the forearm bones with functional impairments being correlated with the forearm pronation.Conclusion The correlation between the patient’s symptoms and the forearm alignment must be taken into account in the classification and when determining indications for surgical treatment distinguishing between functional (< 45° pronation) and dysfunctional (≥ 45° pronation) options.
Impaction bone grafting as a method of choice in bone defect management in the revision hip arthroplasty: a cases series
Authors: Golnik V. N. , Peleganchuk V. A. , Dzhukhaev D. A. , Batrak Yu. M. , Pavlov V. V. 
Published: April 2024

Introduction Reconstruction of the acetabulum during revision arthroplasty is a challenging task in the setting of massive bone defects. Often the only effective method is impaction bone grafting (IBG). The purpose is to demonstrate the capabilities of the X-Change impaction bone grafting technology in replacing acetabular defects as a method of choice for revision hip arthroplasty.Materials and methods In the presented series of cases, the use (IBG) turned out to be the method of choice, allowing for high-quality reconstruction. In each presented case, revision hip arthroplasty was performed with augmentation with a reconstructive mesh or trabecular metal augment to create support and contain the defect to retain the osteoplastic material.Results During follow-up periods of 4.8 to 6.5 years there were no signs of resorption or loosening. According to the Harris hip score the results were 96, 97 and 89 points respectively.Discussion Impaction bone grafting technology is quite versatile. It can be used in various coditions of revision arthroplasty with contained defects of the acetabulum. In contrast to the use of modular revision augmentation systems and additive technologies it makes possible to achieve dense filling of the smallest defects and profile a bed congruent with the acetabular component. The use of cemented fixation makes it possible to further stabilize the impacted bone chips and use mechanotransduction mechanisms that stimulate the bone remodeling. The use of IBG has proven to be an effective technique for the reconstruction of medium-sized acetabular defects in combination with mesh and cement cup, as well as in combination with trabecular metal augments.Conclusion The use of IBG during revision hip arthroplasty can be especially effective for small acetabulum sizes. Combining IBG with trabecular metal augments significantly expands the application of this technology. The use of IBG makes it possible to create a bone reserve, which creates more favorable conditions for inevitable repeated revision interventions.
Soft-tissue origin joint contractures treated with the Ilizarov fixation method
Authors: Yadkikar S. V. , Grover R. , Kaur P. , Yadkikar V. S. , Ojha A. 
Published: April 2024

Introduction Soft-tissue origin joint contractures are a common orthopedic problem. It could be due to various etiologies. Treatment options are available from conservative to surgical methods. These joint contractures slowly become irreversible causing impairment in activities of daily routine. The Ilizarov method is a well established and time-tested method used for management of bone pathologies, but its use in the management of soft-tissue origin contractures is also possible. It has an established role in neoosteogenesis and histogenesis. Fixator assisted soft-tissue stretching done at sustained slow pace leads to histoneogenesis that avoids stretching of neurovascular structures and reduces the possibility of recurrence.Aims To determine usefulness of the Ilizarov method in management of joint contractures of soft tissue origin; to meet functional requirements of patients; to study complications of Ilizarov method in management joint contractures due to soft tissue origin.Material and methods A total of 6 cases of soft-tissue origin joint contractures due to tuberculosis, post‑traumatic stiffness, post-burn contracture, deformity due to a snake bite in the age group from 3 to 55 years were treated with gradual distraction of joint with the Ilizarov method from January 22 to October 23. Two cases were of triple knee deformity, two were post-traumatic elbow stiffness, one was post-burn great toe contracture and one was post snake bite valgus foot contracture. All cases were operated with transarticular Ilizarov frame application and gradual distraction of joints and soft tissue with the help of hinge- and rod distractor assembly done. All cases completed follow up of 1 year. Aggressive physiotherapy was given postoperatively.Results All cases obtained a reasonable functional outcome, with no recurrence of deformity. All patients walk independently.Conclusion The Ilizarov method can be used for treating joint contractures due to traumatic and non‑traumatic pathologies.
Promising osteoplastic materials and surgical technologies in reconstructive treatment of patients with bone nonunion and defects
Authors: Borzunov D. Yu. , Gilmanov R. T. 
Published: April 2024

Introduction Some progress has been made in the development of innovative implantation materials for osteoplastic surgery. However, the problem of bone defect management still remains relevant due to the continued high prevalence of injuries resulting from road accidents, catatrauma, man-made disasters and military operations.The purpose of the work was to analyze the relevant literature and to identify options for solving the problems of bone nonunion and defect management using materials developed on the principles of orthobiology and surgical technologies based on autologous repair.Materials and methods The search for sources was carried out with the ConnectedPapers analytical tool and the capabilities of the eLibrary electronic library using keywords and without restrictions on publication date.Results and discussion Recent publications contain information about the effectiveness of the combination of Masquelet technology and Ilizarov bone transport in patients with acquired and congenital defects, including in the conditions of active purulent infection. According to the literature, a promising autologous bone plastic material is the contents of the bone marrow cavity, containing osteogenic growth factors and bone morphogenetic proteins. Biomaterial is collected using the Reamer-Irrigator-Aspirator system (RIA) from the intramedullary canal of the femur or tibia. Currently, the effectiveness of bone morphogenetic proteins rhBMP-2 and rhBMP-7 in the restorative treatment of patients with bone defects and nonunion of various etiologies has actually been proven. The use of bone morphogenetic proteins has been introduced into foreign treatment protocols. Recent positive results of a combination of surgical technologies have proposed the combined use of the Ilizarov and Masquelet technologies, supplemented by PRP therapy. The basis for the expected effect from the combination of surgical technologies and orthobiological materials are the results of preclinical studies of the osteogenic potential of PRP therapy.Conclusion There are grounds for studying the clinical effect of the combined use of surgical technologies based on autologous reparative processes and materials developed on the principles of orthobiology. It is necessary and advisable to clinically implement the use of bone morphogenetic proteins rhBMP-2 and rhBMP-7 in the reconstructive treatment of patients with bone defects and nonunion of various etiologies. Multicenter clinical studies of a high level of evidence are needed to determine the effectiveness of PRP therapy in the reconstructive treatment of patients with bone nonunion and defects.
Process of Engaging Community and Scientific Partners in the Development of the CIRCL-Chicago Study Protocol
Authors: Smith Justin D. , Carroll Allison J. , Sanuade Olutobi A. , Johnson Rebecca , Abramsohn Emily M. , Abbas Hiba , Ahmad Faraz S. , Eggleston Alice , Lazar Danielle , Lindau Stacy Tessler , McHugh Megan , Mohanty Nivedita , Philbin Sarah , Pinkerton El A. , Rosul Linda L. , Merle James L. , Tedla Yacob G. , Walunas Theresa L. , Davis Paris , Kho Abel 
Published: April 2024

Objectives
Hypertension affects 1 in 3 adults in the United States and disproportionately affects African Americans. Kaiser Permanente demonstrated that a “bundle” of evidence-based interventions significantly increased blood pressure control rates. This paper describes a multiyear process of developing the protocol for a trial of the Kaiser bundle for implementation in under-resourced urban communities experiencing cardiovascular health disparities during the planning phase of this biphasic award (UG3/UH3).

Methods
The protocol was developed by a collaboration of faith-based community members, representatives from community health center practice-based research networks, and academic scientists with expertise in health disparities, implementation science, community-engaged research, social care interventions, and health informatics. Scientists from the National Institutes of Health and the other grantees of the Disparities Elimination through Coordinated Interventions to Prevent and Control Heart and Lung Disease Risk (DECIPHeR) Alliance also contributed to developing our protocol.

Results
The protocol is a hybrid type 3 effectiveness-implementation study using a parallel cluster randomized trial to test the impact of practice facilitation on implementation of the Kaiser bundle in community health centers compared with implementation without facilitation. A central strategy to the Kaiser bundle is to coordinate implementation via faith-based and other community organizations for recruitment and navigation of resources for health-related social risks.

Conclusions
The proposed research has the potential to improve identification, diagnosis, and control of blood pressure among under-resourced communities by connecting community entities and healthcare organizations in new ways. Faith-based organizations are a trusted voice in African American communities that could be instrumental for eliminating disparities.
Avaliação da produção científica das universidades federais brasileiras indexadas na Scopus (2013 – 2022)
Authors: Lopes Arleson Eduardo Monte Palma , Almeida Oriana Trindade de 
Published: April 2024

Introdução: A avaliação da produção científica em bases bibliográficas reconhecidas pela comunidade científica permite por meio de indicadores analisar as métricas de publicação de produtividade dos pesquisadores, universidades, países e citações. Objetivo: O artigo tem como objetivo avaliar o comportado da produção científica das universidades federais pertencentes à região Sudeste e Norte no período de 2013 a 2022 na base bibliográfica Scopus. Metodologia: A metodologia foi feita considerando o procedimento técnico de estudo bibliométrico e abordagem quantitativa por meio das informações bibliográficas coletadas na Scopus. O critério de seleção das universidades foi por meio do Ranking Universitário Folha da Folha de São Paulo, o que resultou na seleção da UFMG, UNIFESP (Sudeste), UFPA e UFAM (Norte). Resultados: Os resultados mostraram que a Universidade Federal de Minas Gerais e a UNIFESP apresentam números de publicações indexadas na Scopus superiores quando comparadas com as quantidades de publicações da UFPA e UFAM indexadas na Scopus. Dentre as universidades selecionadas, a UFMG apresentou em média 3.275,1 documentos indexados entre 2013 a 2022, enquanto a Universidade Federal do Amazonas obteve em média de 343 documentos indexados no período analisado. Em relação ao idioma dos documentos indexados na Scopus das universidades analisadas, observa-se uma concentração em inglês. Conclusão: Conclui-se que as discrepâncias do número de publicações indexadas na Scopus entre as universidades vinculam-se às disparidades da base técnica-científica entre as regiões brasileiras.
Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation (ARO-DECAMP): protocol for a multi-centre, randomized, placebo-controlled feasibility pilot trial
Authors: Yee Noelle , Kulikova Maria , MacFadden Derek , Daneman Nick , Konvalinka Ana , So Miranda , Hota Susy , Martinu Tereza , Kain Kevin , Johnstone Jennie , Walmsley Sharon , Coburn Bryan 
Published: April 2024

Abstract

Background: Antimicrobial resistance (AMR) is a threat to effective treatment of bacterial infections. Gastrointestinal colonization with an antimicrobial resistant organism (ARO) is a risk factor for subsequent systemic infection, and increasing resistance is associated with increased infection recurrence. Patient-level interventions to decrease or minimize antimicrobial harms and reduce gastrointestinal colonization and translocation without worsening selection for AMR have tremendous potential for clinical impact. Despite the prevalence and mortality associated with bloodstream infections, there are no effective therapies for decolonization of the gut microbiome in attempts to potentially decrease the risk of recurrence. Reconstituting the perturbed microbiome is a novel therapeutic modality with the potential to decrease ARO colonization and subsequent infection and combat AMR without additional selection pressure for further AMR. No clinical trial has yet assessed the potential of a therapeutic microbial consortium for ARO decolonization and infection prevention after antibiotic treatment.
Methods: Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation (ARO-DECAMP) is a multi-centre, placebo-controlled, pilot randomized controlled feasibility trial using the microbial consortium Microbial Ecosystem Therapeutic-2. Non-intensive care unit hospitalized patients >18 years of age receiving antibiotic treatment for a bloodstream infection caused by an ARO will be included. Participants will be randomized in a 1:1 ratio to receive either MET-2 or placebo for 10 days, with treatment initiation 2-3 days after completion of antibiotics. Participants will be followed for 180 days, and biological samples will be collected periodically for clinical, ecological, and biomarker outcomes. Recruitment rate and study intervention adherence will be evaluated for feasibility.
Discussion: This study is designed to determine if a trial of administration of microbial consortia after antibiotic treatment for bloodstream infections is feasible. Results of this pilot study will inform the design and sample size of a definitive trial powered to assess the effectiveness of the intervention as a therapeutic strategy for augmenting the microbiome and improving clinical outcomes.
Trial registration: ClinicalTrials.gov, NCT06214403. Registered 19 January 2024, https://clinicaltrials.gov/study/NCT06214403
Determination of nitrosamines in human bronchoalveolar lavage fluid and investigation of relationships with bronchoscopic diagnoses
Authors: çolak sinem , Akyüz Mehmet 
Published: April 2024

Abstract

In this study, the chemometrically optimized, simple and rapid isolation procedures combined with chromatographic techniques have been proposed for determination of volatile and tobacco specific nitrosamines in human bronchoalveolar lavage fluid (BALF) samples. Furthermore, these analyte concentrations were used to classify bronchoscopic diagnoses and their potential as biomarkers was investigated. The optimum conditions for the isolation of nitrosamines from BALF were chemometrically determined with central composite design (CCD).Validation parameters of nitrosamines obtained by Gas Chromatography- Mass Spectroscopy (GC-MS) method under optimum isolation conditions are; recovery: 95% -101%; dedection limit (LOD): 0.40-13.69 pg/mL; quantification limit (LOQ):2.67–78.07 pg/mL and relative standard deviation (RSD): 1.50%-5.60%. Lines and pages must be numbered in the whole document. The samples were divided into 3 groups: patients with bronchoscopic diagnosis of inflammation and polypoid mass and control group. With the function created as a result of discriminant analysis, the samples were classified 100% correctly. The statistical analyze results indicated that in BALF samples especially NNN, NNK and NPIP can be used as both biomarker and indicator of increasing risk for diagnosis of polypoid mass.
A Comprehensive Bibliometric Study of the Interaction Between Built Form, Solar Shading, and Human Behaviour in Warmer Cities
Authors: sakhri hadjira , Maharoof Nusrath , Nicolae Armenciu Daniel , Mamache Fateh Enouar , Emmanuel Rohinton 
Published: April 2024

Abstract

Shade plays a crucial role in creating liveable outdoor spaces in hot arid cities. Numerous studies have been conducted to understand the relationship between human behaviour and built form and how the physical environment responds to human needs and reflects social values. However, there have been limited reviews of the relationship between solar shading that results from built form and behaviour in hot and arid climates. This study aims to highlight the current state of knowledge of the built environment-induced solar shading through articles obtained from Web of Science (WOS), Scopus and Science Direct databases and published between 1 January 2012, and 31 December 2022. Following the PRISMA method and a bibliometrics analysis, from 679 a set of 60 relevant research papers was utilized in this study. The open-source statistical and visualisation software VOSviewer was used mainly for processing and analysing datasets. As a result of the clustering, three main research themes were offered in warmer cities: “thermal comfort and built form”, “built form and shadow”, and “shading and behaviours”. The findings are valuable in terms of mapping and provide a view to deriving usable knowledge relevant to sustainable design practice in warmer places.
Predictors of quality of life and resilience in patients with ovarian cancer during the COVID-19 pandemic: a cross-sectional study
Authors: Schilling Larissa , Toussaint Anne , Weigel Angelika , Lewitz Dorothea , Aust Golo , Töllner Jeanne , Oskay-Özcelik Gülten , Hasenburg Annette , Löwe Bernd , Schmalfeldt Barbara 
Published: April 2024

Abstract

Purpose
The aim of this cross-sectional study was to investigate the psychosocial burdens of patients with ovarian cancer during the COVID-19 pandemic.
Methods
Ninety-three patients diagnosed with ovarian cancer answered a quantitative survey during the COVID-19 pandemic assessing pandemic-related psychosocial impairment. The following domains, among others, were assessed: quality of life and therapy assessment (Functional Assessment of Cancer Therapy [FACT-G7]); anxiety (Generalized Anxiety Disorder Scale-7 [GAD7]); depression (Patient Health Questionnaire-2 [PHQ2]); global physical, mental, and social health (PROMIS items]); and resilience (Brief Resilience Scale [BRS]). Patient groups were compared via analyses of variance ([first-line treatment vs. second-line treatment vs. subsequent treatment] and [patients at younger age at start of treatment vs. older patients]) in terms of psychological impairment. Regression analyses were performed to predict preserved quality of life and resilience.
Results
Most patients rated their physical health, mental health, and satisfaction with social activities as good. Eighty-five patients (91.4%) were somewhat or very concerned about the pandemic. In general, patients on first-line therapy reported a better quality of life (p = 0.03) and better general health (p = 0.014) than those on at least second-line therapy. Patients who were younger at the start of treatment (< 65 years) reported significantly more concern about the pandemic than older patients (p = 0.008). Predictors of quality of life (FACT-7) were general health (global item), severity of depression (PHQ-2), and type of therapy. Predictors of resilience (BRS) were severity of anxiety (GAD-7) and mental health (global item).
Conclusions
Patients in the first line of treatment, and younger patients in particular, might benefit from support in coping with pandemic-related burdens. To ensure the highest possible resilience and quality of life in this patient group, attention should also be paid to potential psychological distress, which should be treated alongside the cancer.
Characteristics and Clinical Outcomes Associated with Appendix Location in Children with Acute Appendicitis
Authors: Echeverry Jhon M. Escobar , Valero Juan J. , Alfonso Natalia Guzmán , Fierro Fernando , Molina Iván D. 
Published: April 2024

Abstract

PURPOSE: To categorize appendix location with a modified classification system and describe the outcomes associated with each location.
METHODS: This was a prospective observational cohort study of children who underwent laparoscopic appendectomy at a reference children’s hospital. The diagnosis of acute appendicitis (AA) was confirmed by the pathology department, and clinical history data were obtained. The location of the appendix was classified as retrocecal (RA), pelvic (PEA), or right iliac fossa (RIF), and an intraoperative photograph was taken for confirmation.
RESULTS: The location of the appendix was divided into three groups (RIF 42%, PEA 33%, and RA 25%). Significant differences were found in the time of symptom onset (RA >48 hours in 54.5% of patients, p=0.001) and in the ultrasound diagnosis of appendicitis (RIF 49.3%, RA 25.9%, PEA 24.6%, p=0.01). The primary outcome assessed was appendix perforation, which also significantly differed between appendix locations (average 37.8%, PEA 46%, p=0.001).
CONCLUSIONS: The classification of the location of the appendix in RIF, PEA and RA was clear, simple, and reproducible, with RIF being the most common location. Pelvic localization was associated with the presence of perforation, possibly because signs of peritoneal irritation are less usual in these children, and perforation was less observed via ultrasound.