bluuebunny/crossref_metadata_2025_split huggingface dataset:
GENDER DIFFERENCES ON CLINICAL OUTCOMES IN PATIENTS UNDERGOING TRANSCATHETER PULMONARY VALVE IMPLANTATION
Authors: Marzullo R , Laudadio R , Solimene A , Giordano M , Gaio G , Cappelli Bigazzi M , Palladino T , Sarubbi B , Russo M 
Published: May 2024

Abstract

Background
The impact of gender on clinical outcomes after Transcatheter Pulmonary Valve Implantation (TPVI) in patients with Congenital Heart Diseases (CHDs) is not well investigated.

Objectives
This is a retrospective single center study including 54 consecutive patients with CHDs referred to TPVI between 2010 and 2023 in our cardiac catheterization laboratory. Differences in–hospital, short– and medium–term outcomes between male and female were examined.

Methods and Results
Women comprised 43% of the cohort. The mean age did not differ among the groups (female: 26 +14 yrs vs male: 27+14 yrs). No significant difference in the type of implanted valve was found according the gender (Melody Valve: 31% in females vs 40% in males, p= 0.92; Sapien 11% in females vs 16.6% in males, p= 0.85). Despite women had higher rates of peri–procedural complications (60% vs 40%, p–value =0.05), in hospital events were similar in both groups (45% in females vs 55% in males, p value =0.9). The only exitus occurred in a woman. Median medium–term follow–up was 4,1 years (range 1 months–12.2 years). Out of total 37 MACEs, 19 occured in males and 18 females, (p–value=0.18). There was no significant differences in the rate of endocarditis (33% in females vs 64% males; p–value = 0.53); re–hospitalization (48% females vs 52% in males, p–value = 0.36), arrhythmias (46% in females vs 54% in males, p–value =0.76) and re–intervention (56% females vs 44% males, p–value = 0.18) between women and men.

Conclusions
Women with CHDs undergoing TPVI present higher rate of peri– operative complications compared to men but showed comparable outcomes at medium term follow up .
TRANSCATHETER BICAVAL VALVES SYSTEM IMPLANTATION FOR SEVERE TRICUSPID REGURGITATION. IMPORTANCE OF THE LOAD
Authors: Serra W , Vignali L 
Published: May 2024

Abstract
The management of patients with severe symptomatic tricuspid regurgitation (TR) remains extremely challenging for Cardiac Heart Team. Studying the load on the right ventricle and the interaction between among the ventricle, valve and pulmonary artery could be the key to detecting such patients. . The systolic pulmonary artery pressure (sPAP)/ pulmonary artery acceleration time (PAAT) ratio could be used as an indicator a marker of pulmonary vascular load, to identify patients who could benefit from transcatheter tricuspid valve repair (TTVR). In this case report we describe a patients with severe tricuspid regurgitation and mild pre–capillary pulmonary hypertension. . sPAP/PAP ratio was 0.6. After extensive discussion inside of the ‘Parma Heart Team’,cardiac surgery was ruled out. Other percutaneous device were excluded for the dilatation of tricuspid annulus and the retraction of the flaps. The choice of the device was directed toward a bicaval device called ‘TricValve’. Device implantation:The two fully pre–mounted devices are implanted via femoral access with fluoroscopy and transesophageal echo guidance under monitored anesthesia care.At the ECO– CT control, the dimensions of the IVC were reduced (30mm from 41mm) while the hepatic vein backflow was absent . In this case device placement prevents regurgitant flow in the IVC and SVC, reduced liver congestion and right ventricle stroke volume into the pulmonary system and cardiac output was improved.The patient’s selection, the ventricular–arterial coupling and the type of device depending on the anatomic functional conditions are the challenges. sPAP/PAP ratio &lt; 0.6 could be a good predictor of the success of the procedure,but will have to be validated in a larger study.
Defects in diffusion barrier function of ciliary transition zone caused by ciliopathy variations of TMEM218
Authors: Fujii Taiju , Liang Luxiaoxue , Nakayama Kazuhisa , Katoh Yohei 
Published: May 2024

Abstract
Primary cilia are antenna-like structures protruding from the surface of various eukaryotic cells, and have distinct protein compositions in their membranes. This distinct protein composition is maintained by the presence of the transition zone (TZ) at the ciliary base, which acts as a diffusion barrier between the ciliary and plasma membranes. Defects in cilia and the TZ are known to cause a group of disorders collectively called the ciliopathies, which demonstrate a broad spectrum of clinical features, such as perinatally lethal Meckel syndrome (MKS), relatively mild Joubert syndrome (JBTS), and nonsyndromic nephronophthisis (NPHP). Proteins constituting the TZ can be grouped into the MKS and NPHP modules. The MKS module is composed of several transmembrane proteins and three soluble proteins. TMEM218 was recently reported to be mutated in individuals diagnosed as MKS and JBTS. However, little is known about how TMEM218 mutations found in MKS and JBTS affect the functions of cilia. In this study, we found that ciliary membrane proteins were not localized to cilia in TMEM218-knockout cells, indicating impaired barrier function of the TZ. Furthermore, the exogenous expression of JBTS-associated TMEM218 variants but not MKS-associated variants in TMEM218-knockout cells restored the localization of ciliary membrane proteins. In particular, when expressed in TMEM218-knockout cells, the TMEM218(R115H) variant found in JBTS was able to restore the barrier function of cells, whereas the MKS variant TMEM218(R115C) could not. Thus, the severity of symptoms of MKS and JBTS individuals appears to correlate with the degree of their ciliary defects at the cellular level.
An endogenous retrovirus regulates tumor-specific expression of the immune transcriptional regulator SP140
Authors: Dziulko Adam K , Allen Holly , Chuong Edward B 
Published: May 2024

Abstract
Speckled Protein 140 (SP140) is a chromatin reader with critical roles regulating immune cell transcriptional programs, and SP140 splice variants are associated with immune diseases including Crohn’s disease, multiple sclerosis, and chronic lymphocytic leukemia. SP140 expression is currently thought to be restricted to immune cells. However, by analyzing human transcriptomic datasets from a wide range of normal and cancer cell types, we found recurrent cancer-specific expression of SP140, driven by an alternative intronic promoter derived from an intronic endogenous retrovirus (ERV). The ERV belongs to the primate-specific LTR8B family and is regulated by oncogenic mitogen-activated protein kinase (MAPK) signaling. The ERV drives expression of multiple cancer-specific isoforms, including a nearly full-length isoform that retains all the functional domains of the full-length canonical isoform and is also localized within the nucleus, consistent with a role in chromatin regulation. In a fibrosarcoma cell line, silencing the cancer-specific ERV promoter of SP140 resulted in increased sensitivity to interferon-mediated cytotoxicity and dysregulation of multiple genes. Our findings implicate aberrant ERV-mediated SP140 expression as a novel mechanism contributing to immune gene dysregulation in a wide range of cancer cells.
Postoperative quality of life and pain after upper hemisternotomy and conventional median sternotomy for aortic valve replacement: results of a randomized clinical trial
Authors: Klop Idserd D G , Van Putte Bart P , Kloppenburg Geoffrey T L , Klautz Robert J M , Sprangers Mirjam A G , Nieuwkerk Pythia T , Klein Patrick 
Published: May 2024

Abstract

OBJECTIVES
Surgical aortic valve replacement through conventional sternotomy yields excellent results. Minimally invasive techniques are deemed equally safe and serve as a viable and less traumatic alternative. However, it is unclear how both surgical techniques affect patient-reported outcomes. The objective of this trial is to compare postoperative cardiac-related quality of life and postoperative pain after upper hemisternotomy and conventional surgical aortic valve replacement.

METHODS
In this single-centre, open-label, investigator-initiated randomized clinical trial, patients were randomized to upper hemisternotomy or conventional full median sternotomy. Patients unable to undergo randomization were monitored prospectively (registry group). Primary outcome was cardiac-specific quality of life, measured with the Kansas City Cardiomyopathy Questionnaire up to 1 year postoperatively.

RESULTS
Patients undergoing upper hemisternotomy had a significantly higher physical limitation domain score across all postoperative time points than patients undergoing conventional surgical aortic valve replacement (estimated mean difference 2.12 points; P = 0.014). Patients undergoing upper hemisternotomy were more likely to have a pain score &lt;30 the first 2 days postoperatively than patients undergoing conventional surgical aortic valve replacement (odds ratio 2.63; P = 0.007). This was associated with reduced opioid analgesic intake. Postoperative surgical outcome did not differ between both groups.

CONCLUSIONS
Surgical aortic valve replacement through both conventional sternotomy and upper hemisternotomy resulted in clinically similar and important improvements in quality of life, with a small advantage for upper hemisternotomy, while there was no compromise in safety.
Modeling the growth of Aspergillus brasiliensis affected by a nonthermal plasma
Authors: Zdeňková Kamila , Jirešová Jana , Lokajová Eliška , Klenivskyi Myron , Julák Jaroslav , Marin Marco Antonio Lopez , Tichá Petra , Domonkos Mária , Demo Pavel , Scholtz Vladimír 
Published: May 2024

Abstract

Aim
The main objective of the study was to develop and validate a model for the growth of Aspergillus brasiliensis on surfaces, specifically on agar culture medium. An additional aim was to determine conditions for complete growth inhibition of this micromycete using two different nonthermal plasma (NTP) sources.

Methods and results
The developed model uses two key parameters, namely the growth rate and growth delay, which depend on the cultivation temperature and the amount of inoculum. These parameters well describe the growth of A. brasiliensis and the effect of NTP on it. For complete fungus inactivation, a single 10-minute exposure to a diffuse coplanar surface barrier discharge was sufficient, while a point-to-ring corona discharge required several repeated 10-minute exposures at 24-h intervals.

Conclusions
The article presents a model for simulating the surface growth of A. brasiliensis and evaluates the effectiveness of two NTP sources in deactivating fungi on agar media.
Picturing the flora of China
Authors: Coulton Richard 
Published: May 2024

Abstract
This paper traces the provenance of some 2,400 plant paintings obtained by early British commercial travellers to Xiamen 廈門, long pre-dating the later ‘export trade’ in Chinese botanical art. Nine principal sets of paintings form five ‘assemblages’ across the British Library and Oak Spring Garden Foundation in Upperville, Virginia. Each painting, in one of two styles, depicts a single plant labelled with its Chinese name. The first style (‘boneless’) either deploys limited outlines to denote form or lacks outlines altogether, and incorporates resemblances to traditions of bencao 本草 (materia medica) illustration and huaniaohua 花鳥畫 (flower-and-bird) painting. The second uses prominent inked outlines and more firmly resembles bencao illustrations. Two merchants, James Cuninghame and Christopher Brewster, are identified as purchasers of some paintings, and their acquisitions entered the metropolitan collections of James Petiver and Sir Hans Sloane. A single Chinese actor, ‘Dr Bun-ko’, is named in an annotation on 309 ‘Bunko–Brewster Paintings’ which have newly been shown to encompass holdings at the British Library and Oak Spring.
CP factor model for dynamic tensors
Authors: Han Yuefeng , Yang Dan , Zhang Cun-Hui , Chen Rong 
Published: May 2024

Abstract
Observations in various applications are frequently represented as a time series of multidimensional arrays, called tensor time series, preserving the inherent multidimensional structure. In this paper, we present a factor model approach, in a form similar to tensor CANDECOMP/PARAFAC (CP) decomposition, to the analysis of high-dimensional dynamic tensor time series. As the loading vectors are uniquely defined but not necessarily orthogonal, it is significantly different from the existing tensor factor models based on Tucker-type tensor decomposition. The model structure allows for a set of uncorrelated one-dimensional latent dynamic factor processes, making it much more convenient to study the underlying dynamics of the time series. A new high-order projection estimator is proposed for such a factor model, utilizing the special structure and the idea of the higher order orthogonal iteration procedures commonly used in Tucker-type tensor factor model and general tensor CP decomposition procedures. Theoretical investigation provides statistical error bounds for the proposed methods, which shows the significant advantage of utilizing the special model structure. Simulation study is conducted to further demonstrate the finite sample properties of the estimators. Real data application is used to illustrate the model and its interpretations.
The Human Being as the Image of God
Authors: Greenberg Irving (Yitz) 
Published: May 2024

Abstract
This is a theological exposition of the biblical statement that the human being is created in the image of God (Genesis 1:26). The treatment concludes that this affirmation is the clal gadol, the foundational principle of the whole Torah (as Ben Azzai says, Talmud Yerushalmi, Nedarim, ch. 9, h. 4). There are four dimensions to the image of God: (1) Intrinsic dignities—that all human beings (no matter gender, skin color, race, religion) are endowed by their Creator with three intrinsic dignities: infinite value, equality, and uniqueness; (2) Capabilities—God has infinite consciousness, power, relationship (=love), freedom, and life. Humans have these capabilities in a finite but remarkable, i.e., Godlike, form. According to Rabbi Joseph B. Soloveitchik, humans fulfill the commandment of Imitatio Dei (v’halachta b’drachav) by developing these capabilities. God bestows these capabilities on humans to use in fulfilling a mission to perfect God’s Creation in partnership with the Divine (=covenant); (3) These dignities are rooted in love. That all humans possess these dignities reflects the fact that God loves all life, especially humans (the most advanced form of life); (4) Prophetic messianism envisions this planet turned into a Garden of Eden (paradise). This is a reality worthy of an image of God, i.e., the enemies of life (poverty, hunger, oppression, war, sickness) are overcome and the fullness of human dignity (infinite value, equality, uniqueness) is honored, in actual practice, in daily life.
Continuum emission from within the plunging region of black hole discs
Authors: Mummery Andrew , Ingram Adam , Davis Shane , Fabian Andrew 
Published: May 2024

ABSTRACT
The thermal continuum emission observed from accreting black holes across X-ray bands has the potential to be leveraged as a powerful probe of the mass and spin of the central black hole. The vast majority of existing ‘continuum fitting’ models neglect emission sourced at and within the innermost stable circular orbit (ISCO) of the black hole. Numerical simulations, however, find non-zero emission sourced from these regions. In this work, we extend existing techniques by including the emission sourced from within the plunging region, utilizing new analytical models that reproduce the properties of numerical accretion simulations. We show that in general the neglected intra-ISCO emission produces a hot-and-small quasi-blackbody component, but can also produce a weak power-law tail for more extreme parameter regions. A similar hot-and-small blackbody component has been added in by hand in an ad hoc manner to previous analyses of X-ray binary spectra. We show that the X-ray spectrum of MAXI J1820+070 in a soft-state outburst is extremely well described by a full Kerr black hole disc, while conventional models that neglect intra-ISCO emission are unable to reproduce the data. We believe this represents the first robust detection of intra-ISCO emission in the literature, and allows additional constraints to be placed on the MAXI J1820 + 070 black hole spin which must be low a• &lt; 0.5 to allow a detectable intra-ISCO region. Emission from within the ISCO is the dominant emission component in the MAXI J1820 + 070 spectrum between 6 and 10 keV, highlighting the necessity of including this region. Our continuum fitting model is made publicly available.
An evaluation of the BALROG and RoboBA algorithms for determining the position of Fermi/GBM GRBs
Authors: López K Ocelotl C , Watson Alan M , Lee William H , Becerra R L , Pereyra Margarita 
Published: May 2024

ABSTRACT
The Fermi/GBM instrument is a vital source of detections of gamma-ray bursts and has an increasingly important role to play in understanding gravitational-wave transients. In both cases, its impact is increased by accurate positions with reliable uncertainties. We evaluate the RoboBA and BALROG algorithms for determining the position of gamma-ray bursts detected by the Fermi/GBM instrument. We construct a sample of 54 bursts with detections both by Swift/BAT and by Fermi/GBM. We then compare the positions predicted by RoboBA and BALROG with the positions measured by BAT, which we can assume to be the true position. We find that RoboBA and BALROG are similarly precise for bright bursts whose uncertainties are dominated by systematic errors, but RoboBA performs better for faint bursts whose uncertainties are dominated by statistical noise. We further find that the uncertainties in the positions predicted by RoboBA are consistent with the distribution of position errors, whereas BALROG seems to be underestimating the uncertainties by a factor of about 2. Additionally, we consider the implications of these results for the follow-up of the optical afterglows of Fermi/GBM bursts. In particular, for the DDOTI wide-field imager we conclude that a single pointing is best. Our sample would allow a similar study to be carried out for other telescopes.
Fast emulation of two-point angular statistics for photometric galaxy surveys
Authors: Bonici Marco , Biggio Luca , Carbone Carmelita , Guzzo Luigi 
Published: May 2024

ABSTRACT
We develop a set of machine-learning-based cosmological emulators, to obtain fast model predictions for the C(ℓ) angular power spectrum coefficients, characterizing tomographic observations of galaxy clustering and weak gravitational lensing from multiband photometric surveys (and their cross-correlation). A set of neural networks are trained to map cosmological parameters into the coefficients, achieving, with respect to standard Boltzmann solvers, a speed-up of $\mathcal {O}(10^3)$ in computing the required statistics for a given set of cosmological parameters, with an accuracy better than 0.175 per cent (&lt;0.1 per cent for the weak lensing case). This corresponds to $\lesssim 2~{{\ \rm per\ cent}}$ of the statistical error bars expected from a typical Stage IV photometric surveys. Such overall improvement in speed and accuracy is obtained through (i) a specific pre-processing optimization, ahead of the training phase, and (ii) an effective neural network architecture. Compared to previous implementations in the literature, we achieve an improvement of a factor of 5 in terms of accuracy, while training a considerably lower amount of neural networks. This results in a cheaper training procedure and a higher computational performance. Finally, we show that our emulators can recover unbiased posteriors when analysing synthetic Stage-IV galaxy survey data sets.
Annotation and visualization of parasite, fungi and arthropod genomes with Companion
Authors: Haese-Hill William , Crouch Kathryn , Otto Thomas D 
Published: May 2024

Abstract
As sequencing genomes has become increasingly popular, the need for annotation of the resulting assemblies is growing. Structural and functional annotation is still challenging as it includes finding the correct gene sequences, annotating other elements such as RNA and being able to submit those data to databases to share it with the community. Compared to de novo assembly where contiguous chromosomes are a sign of high quality, it is difficult to visualize and assess the quality of annotation. We developed the Companion web server to allow non-experts to annotate their genome using a reference-based method, enabling them to assess the output before submitting to public databases. In this update paper, we describe how we have included novel methods for gene finding and made the Companion server more efficient for annotation of genomes of up to 1 Gb in size. The reference set was increased to include genomes of interest for human and animal health from the fungi and arthropod kingdoms. We show that Companion outperforms existing comparable tools where closely related references are available.
Effector Cs02526 from Ciboria shiraiana induces cell death and modulates plant immunity
Authors: Zhang Shuai , Li Ruolan , Fan Wei , Chen Xuefei , Liu Shuman , Zhu Panpan , Gu Xiaohui , Wang Shuchang , Zhao Aichun 
Published: May 2024

Abstract
Sclerotinia disease is one of the most devastating fungal diseases worldwide, as it reduces the yields of many economically important crops. Pathogen-secreted effectors play crucial roles in infection processes. However, key effectors of Ciboria shiraiana, the pathogen primarily responsible for sclerotinia disease in mulberry (Morus spp.), remain poorly understood. In this study, we identified and functionally characterized the effector Cs02526 in C. shiraiana and found that Cs02526 could induce cell death in a variety of plants. Moreover, Cs02526-induced cell death was mediated by the central immune regulator brassinosteroid insensitive 1-associated receptor kinase 1, dependent on a 67-amino acid fragment. Notably, Cs02526 homologs were widely distributed in hemibiotrophic and necrotrophic phytopathogenic fungi, but the homologs failed to induce cell death in plants. Pretreatment of plants with recombinant Cs02526 protein enhanced resistance against both C. shiraiana and Sclerotinia sclerotiorum. Furthermore, the pathogenicity of C. shiraiana was diminished upon spraying plants with synthetic dsRNA-Cs02526. In conclusion, our findings highlight the cell death-inducing effector Cs02526 as a potential target for future biological control strategies against plant diseases.
Luxury brand cars, racial profiling, and citations: Testing the social conditioning model and illusory correlation
Authors: Jackson Leah , Vito Anthony G 
Published: May 2024

Abstract
This study considers the issue of racial profiling in traffic stop citations for young Hispanic male citizens (YHM), young Black male citizens (YBM), and young White male (YWM) citizens stopped while driving a luxury brand car in either majority white cities or majority Hispanic cities. The current study utilized two different datasets: the Illinois traffic stop data (2016–18) and the 2016 LEMAS. The authors used the social conditioning model and illusory correlation as a theoretical explanation for police officer decision-making. The current findings show evidence of racial profiling only for stops involving YHM drivers stopped in majority white cities while driving a luxury brand car for either a safety stop or an investigatory stop ending in a citation. No evidence of racial profiling was found for either YBM drivers stopped in majority white cities or for either YBM drivers or YWM drivers stopped in majority Hispanic cities.