bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences in the Associations Among Parenting, Socioeconomic Status, and Error Monitoring Among Adolescents
Authors: Pirzada Saad , Valadez Emilio A. 
Published: February 2025

ABSTRACTThe error‐related negativity (ERN) is a frontocentral deflection in the human EEG that is sensitive to error commission. Past research indicates that the ERN is modulated by individual differences in socioeconomic status (SES) and parenting style; however, there is limited research examining sex‐differences in how these factors influence the ERN. The present study aimed to elucidate the relations among SES, parenting style, sex, and the ERN. In this study, 176 participants from a relatively large longitudinal study performed a Flanker task at age 15 years to measure the ERN. At the same assessment time, parenting style was assessed via parent report using the Parenting Styles and Dimension Questionnaire (PSDQ). Parents reported on their highest level of education which was used as an indicator of household SES. Authoritarian and permissive parenting scores each significantly moderated the relation between maternal education and ERN amplitudes, but in both cases this moderation differed by child sex. There were no significant direct associations between maternal education and ERN amplitude or between parenting scores and ERN amplitude. Overall, findings may suggest sex differences in the impact of social context on error monitoring development. This study highlights (1) that parenting behaviors may modulate the impact of SES on cognitive control and and (2) the importance of considering sex differences when examining the interplay between SES, parenting, and cognitive control.
Stress analysis of crack characteristic of anthracite under dynamic loading
Authors: Bai Yun , Gao Feng , Luo Ning , Zhang Zhizhen , Niu Yue , Su Shanjie 
Published: February 2025

AbstractThe coal dynamic characteristic stress identification under dynamic load is important for guiding underground mineral mining and predicting underground dynamic disasters. In this article, the dynamic compression test of anthracite under five strain rates is carried out, the evolution law of three kinds of crack characteristic stress is analyzed, and a prediction model of the crack characteristic stress threshold considering the strain rate effect is established. Then, the rationality of crack characteristic stress under dynamic loading is discussed from the damage evolution standpoint, and the crack extension response mechanism during dynamic compression of anthracite is discussed. The result shows that the crack characteristic stress threshold is significantly influenced by the strain rate. The three characteristic stress thresholds are positively correlated with the strain rate, but the ratios to the crest stress gradually decrease. The increase in the strain rate strongly contributes to the crack extension behavior of anthracite. In the crack unstable extension phase, because of the increase of the strain rate, anthracite shows more energy dissipation under the same deformation in association with the stress concentration effect and the dynamic strength enhancement effect. The crack propagation rate is increased, the crack propagation path of the section is more complex, and more severe damage occurs before the dynamic failure of anthracite, which leads to even more severe damage.
Next Steps in Use of the Eating Disorder Examination and Related Eating Disorder Assessments: A Call for Consensus
Authors: Reilly Erin E. , Gorrell Sasha , Chapa Danielle A. N. , Drury Catherine R. , Stalvey Erin , Goldschmidt Andrea B. , Le Grange Daniel 
Published: February 2025

ABSTRACTObjectiveSince its publication almost 35 years ago, the Eating Disorder Examination (EDE) and its companion paper‐and‐pencil self‐report—the Eating Disorder Examination‐Questionnaire (EDE‐Q)—have remained some of the most widely used and studied tools for the assessment of eating disorder symptoms. Widespread use of the EDE has persisted despite notable limitations of the measure, while other assessment tools developed in the decades since have been inconsistently adopted, both of which may have consequences for accumulation and replication of knowledge within the field.MethodIn the current forum, we propose that common critiques of the EDE are representative of larger issues that face the subfield of ED assessment. Therefore, we propose that larger efforts focused on (a) developing decision‐making frameworks for assessment evaluation and selection, (b) alignment in flexibly adapting measurements for use in different contexts, and (c) consensus in reporting on assessment implementation and alteration should be paired with and could effectively inform more pragmatic revision of tools like the EDE.ResultsWe outline a range of recommendations through which the field can address issues related to lack of consensus in assessment‐related decision‐making, inconsistency in measure administration and scoring, and inadequate reporting on assessment practices in peer‐reviewed journals.DiscussionIn sum, we propose that undertaking planful research regarding current use of the EDE and facilitating field‐wide discussion regarding innovation in measure selection and administration can facilitate needed improvement in assessment rigor, data sharing, and inclusiveness within the field.
Colony Site Selection of Gray Heron (Ardea cinerea) During the Breeding Period at Multiple Spatial Scales
Authors: Tian Ran , Li Donghong , Zhang Shiyu , Zhao Yongbin , Yi Guodong 
Published: February 2025

ABSTRACTThe colony site selection of birds reflects their adaptability to the ecological environment. As one of the most common and widely distributed heron species, the gray heron (Ardea cinerea) serves as an interesting study case for ornithologists. Researchers often study their colony site selection characteristics to understand how they adapt to different ecological environments and how these adaptation strategies affect their survival and reproduction. However, the majority of research has focused solely on studying the gray heron in a single region at scales. To maintain the model's generalization ability and ensure accurate predictions of gray heron colony preferences, we avoided using excessively similar landscapes within a single landscape mode. This study utilizes geographic information systems (GIS) and random forest (RM) models to examine the colony site selection during the breeding period of gray herons across various regions and spatial scales, providing insights into their adaptability and the environmental factors influencing their colony site selection. By conducting research across most regions of China, we gain valuable insights into gray heron adaptability and colony strategies across various environments. The results indicate that potentially suitable foraging habitats are the primary determinant of gray heron colony site selection. When habitat requirements are met, gray heron exhibit a degree of flexibility in colony site choice, highlighting their adaptive behaviors and potentially offering new insights into their widespread distribution. By employing this approach, our findings offer new insights into wildlife conservation, emphasizing the importance of interdisciplinary collaboration in shaping conservation strategies. Additionally, the methods used in this study may be applicable to other bird species and colony groups, providing valuable insights into habitat preferences across diverse ecological contexts.
Droplet Digital PCR Provides Highly Sensitive and Accurate Opsin Gene SNP Detection From Wild Primate Fecal Samples
Authors: Fernandes Arthur G. , Hernández Saúl Cheves , Navaro Ronald López , Kawamura Shoji , Melin Amanda D. 
Published: February 2025

ABSTRACTEvaluating field‐sourced samples with poor‐quality and low‐quantity DNA, like animal feces, presents significant challenges in the field of molecular biology. Nonetheless, recent innovations in PCR technology are promoted as effective tools to overcome many of these issues. Here, we evaluate the efficiency of droplet digital PCR (ddPCR) as a method for color vision assessment from feces of white‐faced capuchins (Cebus imitator) and report frequencies of alleles and genotypes in a wild population. The sex‐linked color vision polymorphism of monkeys in the Americas is driven by single nucleotide polymorphisms (SNPs) in opsin genes at up to three tuning sites. DNA was extracted from fecal samples collected from 211 wild capuchins (53.1% males) in Sector Santa Rosa, Costa Rica: 56 were evaluated with ddPCR, 24 with both ddPCR and Sanger sequencing, and 141 with Sanger sequencing (historical dataset). The same opsins and genotypes were derived for each monkey using Sanger and ddPCR; however, the latter method was far more sensitive and required far fewer samples to reach a definitive genotype. Overall, the most frequent phenotypes were red and green/red. The distribution of genotypes was: Females (N = 99): green/red (35.4%), red/red (33.3%), green/yellow (14.1%), yellow/red (12.1%), yellow/yellow (4.0%), and green/green (1.0%); Males (N = 112): red (60.7%), yellow (23.2%), and green (16.1%). Overall, ddPCR was a reliable method for evaluating color vision noninvasively in wild capuchins with the advantage of excellent sensitivity and high‐throughput. ddPCR is highly robust to PCR inhibitors and can be potentially used to identify other disease‐related SNP mutations noninvasively in wild animals.
5‐Substituted 1,2‐Dihydroxyindolizidines and ‐Pyrrolizidines Related to Swainsonine: Synthesis and Inhibition Study
Authors: Gabko Peter , Šesták Sergej , Moncoľ Ján , Bella Maroš 
Published: February 2025

AbstractDevelopment of selective Golgi α‐mannosidase II inhibitors possessing a modified swainsonine skeleton has recently become a popular field of study due to their great potential in suppressing metastasis. However, most of the studied modifications involve addition of a substituent on the bicycle which makes the synthesis rather complex as five stereogenic centres have to be generated. Inspired by our previously developed synthesis of (5S)‐5‐benzylswainsonines utilizing a fully stereoselective intramolecular reductive amination, we decided to further investigate the versatility of this strategy by preparing a small collection of simplified analogues bearing only two hydroxy groups, thus eliminating one of the stereogenic centres. This contribution reports a concise synthesis of 5‐substituted 1,2‐dihydroxyindolizidines and ‐pyrrolizidines whose key features include small number of steps, high yields and excellent stereoselectivity. The title compounds were also tested for inhibitory activity against a Golgi and a lysosomal α‐mannosidase to assess the effects of the substituents, ring size and missing C8‐hydroxyl on potency and selectivity.
The use of steroids in adult epilepsy: A systematic review
Authors: Walsh Ruth , Doherty Colin P. , Doran Elisabeth 
Published: February 2025

AbstractObjectiveThe objective of this study is to systematically review the clinical studies investigating the use of steroids in adult epilepsy.MethodsThis systematic review utilized Preferred Reporting Items for Systematic Review and Meta‐analysis Protocols (PRISMA‐P) to examine literature on the use of steroids in adult epilepsy. Three databases, Embase, PubMed and Medline, were searched and clinical studies fitting the inclusion and exclusion criteria were included for review.ResultsThere were 4333 articles retrieved after duplicates were removed and 16 met the inclusion criteria. Three of these studied corticosteroid use in seronegative autoimmune epilepsies. There was one study that examined the use of corticosteroids in adult‐onset Rasmussen's Encephalitis. There were three studies which described the use of neurosteroids in various forms of adult epilepsy. The remaining 9 studies were pertaining to the use of corticosteroids in refractory status epilepticus.SignificanceSteroids show favorable outcomes in many forms of adult epilepsy. Yet, there is a paucity of data supporting implementation of this treatment in practice. High‐level evidence such as Randomized‐Controlled Trials investigating the use of corticosteroids in adult epilepsy are required, particularly those examining seronegative autoimmune epilepsy and refractory status epilepticus given the prevalence of these conditions and lack of treatment options.Plain Language SummaryEpilepsy, characterized by repeated seizures often without a known cause, is initially treated with anti‐seizure medications. However, about one third of patients do not become seizure‐free with medication. Steroids, known for their anti‐inflammatory effect, are now being trialed as a seizure treatment for difficult to control seizures because uncontrolled seizures are thought to cause inflammation in the brain. However, the use of steroids as a treatment for uncontrolled seizures has not been researched widely. This article reviews studies exploring the use of steroids in adult epilepsy and finds that there is some evidence that steroids may be able to improve seizures in some cases. Yet, further research is needed to better understand the effect and benefits of steroids in managing epilepsy.
Omalizumab Treated Urticaria Patients Display T Cell and Thrombocyte‐Associated Gene Regulation
Authors: Smola Anna , Hawerkamp Heike C. , Oláh Péter , Kislat Andreas , Duschner Nicole , Homey Bernhard , Meller Stephan 
Published: February 2025

ABSTRACTBackgroundChronic spontaneous urticaria (CSU) is a debilitating inflammatory skin disease with a prevalence of approximately 1% of the population. It is characterized by recurrent itchy wheals and/or angioedema for more than 6 weeks without known triggers leading to a high quality of life impairment. The pathogenesis of CSU remains not fully understood.ObjectiveThis study aimed to explore the pathomechanism of CSU beyond mast cells and IgE‐dependent histamine release and to identify possible biomarkers for the disease and its treatment.MethodsWe investigated a patient cohort in the first month of omalizumab treatment regarding the IgE levels and changes in gene and miRNA expression in peripheral blood. The cohort was divided into responders and nonresponders (depending on the score of the urticaria control test) and compared to a group of healthy controls.ResultsOur messenger RNA and microRNA microarray analyses revealed the greatest changes in expression levels on Day 2 after the first omalizumab dose.ConclusionWe identified several genes and miRNAs of interest, most of which have not been described to be linked to CSU so far, underlining, for example, to T cell involvement or even suggesting platelet involvement.
Geriatric Nutritional Risk Index is a risk factor for long‐term decreases in patient‐reported outcome measures following total knee arthroplasty
Authors: Kokubu Yasuhiko , Kawahara Shinya , Hamai Satoshi , Akasaki Yukio , Sato Taishi , Konishi Toshiki , Inoue Takahiro , Nakashima Yasuharu 
Published: February 2025

AbstractPurposeTotal knee arthroplasty (TKA) is an effective treatment for alleviating pain and improving function in patients with end‐stage knee osteoarthritis. However, factors influencing long‐term patient‐reported outcome measures (PROMs) remain underexplored. This study aimed to evaluate the relationship between preoperative nutritional status, specifically the Geriatric Nutritional Risk Index (GNRI), and the long‐term decline in PROMs following TKA.MethodsWe conducted a retrospective cohort study including patients who underwent TKA between 2000 and 2009. PROMs were assessed using the Knee Society Score (KSS) at two time points: an initial evaluation in 2012 (median postoperative 4 years) and a follow‐up in 2023 (median 13 years). Preoperative GNRI, body mass index (BMI), and other demographic and clinical data were collected from medical records. Statistical analysis included paired t‐tests and multivariate logistic regression to identify independent risk factors for long‐term decline in KSS scores.ResultsA total of 75 patients completed follow‐up assessments. Over the 11‐year follow‐up period, there was a significant decrease in the KSS functional activity scores (p < 0.001), with 47 patients experiencing a decline exceeding the minimal clinically important difference. A multivariate analysis revealed low preoperative GNRI (p = 0.0043) as a significant risk factor for long‐term decline in PROMs.ConclusionPreoperative malnutrition, as indicated by a low GNRI, is a significant risk factor for long‐term decline in functional outcomes following TKA. These findings highlight the importance of preoperative nutritional interventions and rehabilitation for improving the long‐term outcomes of patients undergoing TKA.Level of EvidenceLevel III, retrospective cohort study.
An Economic Evaluation of the TROG 99.03 Trial: Systemic Therapy After Radiotherapy in Early‐Stage Follicular Lymphoma
Authors: Erku Daniel , Tobin Joshua W. D. , Seymour John F. , MacManus Michael , Scuffham Paul , Hapgood Greg 
Published: February 2025

ABSTRACTBackgroundThe TROG 99.03 trial demonstrated improved progression‐free survival for patients with early‐stage follicular lymphoma (FL) treated with systemic therapy using rituximab‐cyclophosphamide, vincristine, prednisolone (R‐CVP) after involved‐field radiotherapy (RT) versus RT. As systemic therapy was associated with more acute toxicity, the possibility of long‐term toxicity, and no survival benefit yet, the cost‐effectiveness of RT+R‐CVP is important.AimWe performed a cost‐effectiveness analysis of RT (reference), RT+CVP, and RT+R‐CVP from the TROG 99.03 trial.MethodsWe constructed a Markov model (15‐year horizon) to compare treatments: RT (reference), RT+CVP and RT+R‐CVP from the 150 patients in the TROG 99.03 trial. Median follow‐up was 11.3 years (range: 4.4–17.8). Lifetime direct health care costs, quality‐adjusted life‐years (QALYs) and incremental cost‐effectiveness ratios (ICERs) were calculated. Australian dollars AUD$50,000 was defined as the proposed willingness‐to‐pay threshold (WTP).ResultsRT+R‐CVP was associated with an improvement of 0.711 QALYs compared to RT, 0.532 QALYs compared to RT+CVP, and was the dominant strategy. The costs of adverse events or retreatment for relapses or transformation had a minimal influence on the ICERs. Sensitivity analyses resulted in ICER values below the WTP with RT+R‐CVP remaining the dominant strategy.ConclusionRT+R‐CVP is clearly cost‐effective and was the dominant strategy in early‐stage FL compared to RT or RT+CVP as it delivers superior outcomes at a lower cost from the Australian tax‐payer's perspective.Trial RegistrationThe authors have confirmed clinical trial registration is not needed for this submission
A Tale of Two Job Searches: An Integrative Review of How Job Seeker Characteristics Shape Informal Job Search Effectiveness
Authors: Porter Caitlin M. , Solanelles Pol , Cullen‐Lester Kristin L. , Pearson Ashley Howell , Du Juan 
Published: February 2025

ABSTRACTInformal job search—the use of personal and professional networks for job search—is a popular job search method. Yet, answers to the questions of whether informal job search is effective (relative to formal job search) and why have not been clearly articulated, hindering research progress and limiting practical recommendations for job seekers and institutions. We endeavored to address these questions via an integrative, interdisciplinary review of how job search methods (i.e., formal vs. informal) and forms of social capital (i.e., types of contacts and tie strength) relate to job search outcomes (i.e., finding a job vs. finding quality employment), and we summarize evidence for the role of job seeker characteristics as key contingencies on this process. In doing so, we uncover “a tale of two job searches,” wherein informal job search effectiveness is dependent upon job seeker characteristics that impart status within the labor market and/or society. Collectively, our review provides much‐needed clarity regarding whether an informal job search is better than a formal job search and why, revealing that answers to these questions depend on who is searching for a job. Considering these insights, we outline an agenda for future research focused on enhancing job seekers' access to social networks and integrating job search and social network perspectives to extend knowledge of how different types of job seekers can more effectively utilize their networks for job search.
Associations among sleep quality, cognitive processing therapy, and posttraumatic stress disorder symptoms in a primary care setting
Authors: Park Nicola , Rouvere Julien , Chase Erin , Blanchard Brittany E. , Kaysen Debra L. , Hendrickson Rebecca C. , Fortney John C. , Cerimele Joseph M. 
Published: February 2025

AbstractEvidence describing the association between sleep quality and trauma‐focused therapy is mixed. This secondary analysis of a primary care sample examined whether (a) baseline sleep quality moderated posttraumatic stress disorder (PTSD) symptom severity over time across groups receiving different doses of cognitive processing therapy (CPT) and (b) sleep quality improved over time with CPT. Participants were 227 adults who screened positive for PTSD and were participating in a clinical trial comparing two models of PTSD treatment delivery in primary care. The Pittsburgh Sleep Quality Index (PSQI) and PTSD Checklist for DSM‐5 (PCL‐5) were used to assess sleep disturbance and PTSD symptom severity, respectively. Multiple linear regression was used to assess whether baseline PSQI scores moderated 12‐month PCL‐5 scores across CPT dosage groups (0 sessions: 51.1%, 1–7 sessions: 31.7%; ≥ 8 sessions [adequate dose]: 17.2%) and whether PSQI scores differed by group at 12‐month follow‐up. Post hoc analyses examined changes in PCL‐5 sleep disturbance items. Baseline sleep disturbance did not moderate the effect of CPT on PTSD severity among participants with an adequate CPT dose, p > .112. Sleep quality improved with adequate dose, B = ‐2.63, SE = 0.75, p < .001. Differences in change scores across groups for PCL‐5 Item 2, F(2, 435) = 11.34, and Item 20, H(2) = 32.04, indicated that participants with an adequate CPT dose had greater reductions in trauma‐related sleep symptoms than those who received 0–7 sessions, ps < .001. Residual post‐CPT sleep impairment despite adequate PTSD improvement warrants further interventions.