bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison of early and delayed arthroscopically-assisted reconstruction of the anterior cruciate ligament using hamstring autograft
Authors: Raviraj A. , Anand A. , Kodikal G. , Chandrashekar M. , Pai S. 
Published: March 2010

Delayed rather than early reconstruction of the anterior cruciate ligament is the current recommended treatment for injury to this ligament since it is thought to give a better functional outcome. We randomised 105 consecutive patients with injury associated with chondral lesions no more severe than grades 1 and 2 and/or meniscal tears which only required trimming, to early (< two weeks) or delayed (> four to six weeks) reconstruction of the anterior cruciate ligament using a quadrupled hamstring graft. All operations were performed by a single surgeon and a standard rehabilitation regime was followed in both groups. The outcomes were assessed using the Lysholm score, the Tegner score and measurement of the range of movement. Stability was assessed by clinical tests and measurements taken with the KT-1000 arthrometer, with all testing performed by a blinded uninvolved experienced observer. A total of six patients were lost to follow-up, with 48 patients assigned to the delayed group and 51 to the early group. None was a competitive athlete. The mean interval between injury and the surgery was seven days (2 to 14) in the early group and 32 days (29 to 42) in the delayed group. The mean follow-up was 32 months (26 to 36). The results did not show a statistically significant difference for the Lysholm score (p = 0.86), Tegner activity score (p = 0.913) or the range of movement (p = 1). Similarly, no distinction could be made for stability testing by clinical examination (p = 0.56) and measurements with the KT-1000 arthrometer (p = 0.93). Reconstruction of the anterior cruciate ligament gave a similar clinical and functional outcome whether performed early (< two weeks) or late at four to six weeks after injury.
Effect of lumbar disc replacement on the height of the disc space and the geometry of the facet joints
Authors: Kafchitsas K. , Kokkinakis M. , Habermann B. , Rauschmann M. 
Published: March 2010

In a study on ten fresh human cadavers we examined the change in the height of the intervertebral disc space, the angle of lordosis and the geometry of the facet joints after insertion of intervertebral total disc replacements. SB III Charité prostheses were inserted at L3-4, L4-5, and L5-S1. The changes studied were measured using computer navigation sofware applied to CT scans before and after instrumentation. After disc replacement the mean lumbar disc height was doubled (p < 0.001). The mean angle of lordosis and the facet joint space increased by a statistically significant extent (p < 0.005 and p = 0.006, respectively). By contrast, the mean facet joint overlap was significantly reduced (p < 0.001). Our study indicates that the increase in the intervertebral disc height after disc replacement changes the geometry at the facet joints. This may have clinical relevance.
Complications associated with distraction osteogenesis for infected nonunion of the femoral shaft in the presence of a bone defect
Authors: Blum A. L. L. , Bongiovanni J. C. , Morgan S. J. , Flierl M. A. , dos Reis F. Baldy 
Published: March 2010

We undertook a retrospective study of 50 consecutive patients (41 male, 9 female) with an infected nonunion and bone defect of the femoral shaft who had been treated by radical debridement and distraction osteogenesis. Their mean age was 29.9 years (9 to 58) and they had a mean of 3.8 (2 to 19) previous operations. They were followed for a mean of 5.9 years (2.0 to 19.0). The mean duration of the distraction osteogenesis was 24.5 months (2 to 39). Pin-track infection was observed in all patients. The range of knee movement was reduced and there was a mean residual leg-length discrepancy of 1.9 cm (0 to 8) after treatment. One patient required hip disarticulation to manage intractable sepsis. In all, 13 patients had persistant pain. Bony union was achieved in 49 patients at a mean of 20.7 months (12 to 35). Although distraction osteogenesis is commonly used for the treatment of infected femoral nonunion with bone defects, it is associated with a high rate of complications.
Successful Treatment of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus Aureus Bacteremia with the Addition of Rifampin to Daptomycin
Authors: Ahmad Nasir M , Rojtman Albert D 
Published: March 2010

OBJECTIVE: To report a case in which daptomycin-nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA) bacteremia was successfully treated with the addition of rifampin to daptomycin. CASE SUMMARY: An 84-year-old male presented with fever and chills following cystoscopy. After culturing was conducted, the patient received single doses of vancomycin and gentamicin and then continued on vancomycin plus ceftazidime. Blood cultures grew MRSA, with vancomycin and daptomycin minimum inhibitory concentrations (MICs) of ≤1 μg/mL and 0.25 μg/mL, respectively. Vancomycin was continued, with trough concentrations maintained >15 pg/mL, but results of blood cultures remained positive. On day 10, therapy was switched to daptomycin 6 mg/kg/day, but culture results remained positive. On day 13, testing for vancomycin heteroresistance was negative, with the MIC unchanged. The vancomycin MIC remained unchanged on day 19, but the daptomycin MIC had increased to 2 μg/mL. Rifampin 300 mg orally twice daily was added on day 20; blood cultures obtained 2 days later were sterile. The patient was discharged to complete a 6-week course of antibiotics and was doing well 4 months following therapy. DISCUSSION: Analysis of MRSA isolates obtained on days 1 and 19 showed an increase in the daptomycin MIC from 0.25 to 2 μg/mL. Because intervening isolates were not available for susceptibility testing, it is not possible to associate this increase with exposure to either vancomycin or daptomycin. Although in vitro synergy was not seen in this case, addition of rifampin to daptomycin therapy resolved the bacteremia. CONCLUSIONS: In patients with persistent MRSA bacteremia, isolates should be retested for susceptibility to both daptomycin and vancomycin, including assessment for vancomycin heteroresistance. Addition of rifampin to daptomycin may be effective for persistent MRSA bacteremia, even if daptomycin MICs are elevated. Prospective studies are needed to define the role of combination therapy.
Reclaiming Revolution in Light of the “Mexican Miracle”:Celestino Gasca and the Federacionistas Leales Insurrection of 1961
Authors: Servín Elisa 
Published: March 2010

“If they want me to give my life in order to get their attention, I'll give it to them.”In the hours before dawn on September 15, 1961, various groups of men armed with machetes, pistols and rifles attempted to take over military posts, police stations and municipal offices throughout Mexico, proclaiming “justice for the poor.” The uprising of the so-calledFederacionistas Lealeswas part of a strategy coordinated by an old revolutionary general, Celestino Gasca Villaseñor, who planned to take power in order to carry out a new agrarian program to benefit the campesinos of Mexico.
Fragmente des Testamentum Domini in georgischer Übersetzung
Authors: Chronz Tinatin , Brakmann Heinzgerd 
Published: March 2010

ABSTRACT
Liturgical books of the oriental churches transmit not a few prayers of the Testamentum Domini. They echo its lost Greek text and its translation in nearly all languages of the Oriens Christianus. A Georgian translation is represented not only by the ordinale in Codex A-86 (10th/11th century) of the National Centre of Manuscripts, Tibilisi (Georgia) but also by the Prayer on healing oil and water in the Palestinian Codex Sinaiticus ibericus O.12 (10th century), here edited for the first time. A different Georgian redaction of this same prayer, used during a penitential celebration, is found in younger manuscripts and may represent the translation of a Greek model not yet identified.
Contradicit apostolus. A particular use of Rom 9,11 in Augustine's Sermo 165
Authors: Partoens Gert 
Published: March 2010

ZUSAMMENFASSUNG
Der Artikel befasst sich mit den §§ 6-8 aus Augustins Sermo 165, einer Predigt, die der Bischof von Hippo während der Pelagianischen Streitigkeiten in der Basilica Maiorum in Karthago gehalten hat (vermutlich im Jahre 417). Die Textpassage stellt einen lebhaften, fiktionalen Dialog zwischen Augustin und einigen Pelagianern dar, die die erstaunliche Auffassung vertreten, jeder Mensch werde unsterblich geboren und sterbe aufgrund der persönlich begangenen Sünde. Mittels einer reductio ad absurdum zeigt Augustin, dass aus dieser Annahme folge, dass Ungeborene bereits im Mutterleib zur Sünde fähig sein müssten. Mit dieser Idee, so Augustin, widersprächen die von ihm erfundenen Pelagianer der Aussage in Röm 9,11, wo die Möglichkeit vorgeburtlicher Sünde gerade verneint wird. Augustin vergleicht diese pelagianische Auffassung mit derjenigen der „Origenisten“, wonach die menschliche Seele vor der Geburt eines Menschen eine himmlische, körperlose Existenz besäße; die Einschließung in die körperliche Existenz durch Geburt sei erst die Folge von im Himmel begangenen Sünden. Diese Verbindung von Pelagianismus und der „origenistischen“ Theorie von den gefallenen Seelen findet sich auch im Dialogus aduersus Pelagianos des Hieronymus aus dem Jahr 415 – wenngleich dieser die Ansichten seiner Gegner mit Hilfe einer anderen reductio ad absurdum zu widerlegen versucht. Der vorliegende Beitrag versteht Augustin, Sermo 165,6-8 als einen rhetorisch durchwirkten Text, dem nicht an einer authentischen Wiedergabe pelagianischer Lehre gelegen ist. Augustin zielt hier nicht auf eine gründliche und ausgewogene Widerlegung verbreiteter pelagianischer Lehren, sondern auf die vollständige Vernichtung seiner Gegner.
Stroke prevention in patients with atrial fibrillation: Is the transcatheter occlusion of left atrial appendage already an alternative to anticoagulation?
Authors: Park Jai-Wun , Leithäuser Boris 
Published: March 2010

AbstractCardiac emboli in patients with atrial fibrillation are one of the major causes of ischemic stroke. Because the vast majority of these cardiac emboli descend from the left atrial appendage (LAA), the therapeutic strategy of percutaneous transcatheter occlusion of the LAA by means of a mechanical implant was a logical consequence. Three different devices have been developed and used in humans: PLAATO, WATCHMAN, and ACP. The PLAATO implant, a “soccer ball” shaped self-expanding nitinol cage has demonstrated stroke prevention capability in small, uncontrolled studies. The WATCHMAN implant, a “half rugby ball” shaped self-expanding nitinol cage, has demonstrated non inferiority compared to warfarin treatment in the randomized, controlled PROTECT AF trial. The ACP implant is also a self-expanding nitinol cage. However, its design is of fundamental difference compared to the other two implants. ACP consists of two parts connected by a short waist, which are an “ice-hockey puck” shaped body for the implant fixation in the appendage wall, and a flexible disc for sealing the appendage ostium. Due to the very flexible connecting waist between the two parts, ACP implant adapts itself to the LAA, which appears in significant individual structural variabilities. The currently unpublished initial experience with ACP in Europe is encouraging. Transcatheter occlusion of the LAA offers an appealing way to reduce the incidence of cardioembolic stroke in patients with atrial fibrillation. However, the concerns about procedural safety and the need for long-term follow up should be addressed before this potentially important technology is deployed widely. The transcatheter occlusion of left atrial appendage, therefore, has the potential to become, but is not yet a real alternative to anticoagulation.
Preoperative coronary revascularization for the reduction of perioperative ischemic complications in patients undergoing major vascular surgery
Authors: Kertai Miklós D. , Gál János 
Published: March 2010

AbstractPatients undergoing vascular surgery are at increased risk for perioperative cardiac complications related to the frequent prevalence of underlying coronary artery disease. Cardiac evaluation and noninvasive tests may often identify patients at increased cardiac risk in whom coronary angiography is often considered with subsequent coronary revascularization for the purpose of improving perioperative and long-term cardiac outcomes. However, there has been controversy as to the indications and efficacy for type of revascularization and how coronary revascularization may add to the effect of optimized medical therapy for the reduction of cardiac complications. The aim of this review is to summarize the role of preoperative coronary revascularization in the reduction of perioperative cardiac complications in patients with coronary artery disease undergoing major vascular surgery.
Combination of post mortem coronary angiography, corrosion cast method and multi-slice computed tomography (MSCT) for diagnostic improvement in pathology and forensics
Authors: Nemeskéri Á. , Matlakovics B. , Dudás I. , Molnár B. , Bartykowski A. , Kiss M. , Kristóf I. , Törő K. , Karlinger K. 
Published: March 2010

Abstract
In recent years, post mortem multi-slice computed tomography (MSCT) is increasingly applied for forensic and pathologic examination. However, classical dissection remains dominant in everyday practice. Lack of quantifiable data on the coronary system has become a disadvantageous attribute of traditional autopsy. Therefore, post mortem MSCT angiography was performed in 80 ex corpo hearts with the aim of improving the accuracy and quantitative documentation of pathologic and forensic diagnoses of coronary artery disease (CAD). Hearts were perfused by introducing a new oily or synthetic resin, or using both contrast materials successively. Then the perfused organs were processed for imaging. Detailed angiographic analysis enabled us to localize, map and quantify coronary calcifications, stenoses, and to characterize the types of atherosclerotic plaques. Significant early or late complications of widely used percutaneous coronary interventions (PCI) and coronary bypass surgery (CABS) could be revealed using CT analysis. Furthermore, by using our oily contrast material and CT imaging, we could identify and visualize the clinically important small caliber nodal arteries (diameter 0.4–2.0 mm). The present work suggests that post mortem CT angiography and post-processing of the data may improve the quality of pathologic and forensic diagnosis. Our collection of coronary casts including digital data are available for further analysis.
Expression pattern of molecular chaperones after liver transplantation in hepatitis C positive recipients. Relation to serum HCV-RNA titers
Authors: Nemes B. , Doros A. , Holczbauer Á. , Sárváry E. , Nagy P. , Lengyel G. , Kiss A. , Schaff Zs. 
Published: March 2010

Abstract
Hepatitis C (HCV) is one of the main causes of liver transplantation (OLT). Previously we have reported that high serum C RNA level correlates with the severity of histopathological signs and poor clinical outcome. The core antigen of virus C is known to interfere with chaperones in the hepatocytes, results in an endoplasmic reticulum (ER) stress. In this study HCV positive liver transplanted patients were evaluated, whether there are correlations among chaperone expression, recurrence and viral titer. Patients were enrolled after surviving the first month following OLT. Sera were collected regularly, and biopsies were taken on demand following OLT. The diagnosis of recurrent HCV was proven by Knodell-Ishak scoring. In this case ribavirin+interferon were initiated, and maintained for one year. All chaperones were upregulated in the transplanted liver graft showing recurrent hepatitis C disease. ATF6, GP96, GRP78, CNX and CLR chaperones were upregulated significantly compared to their levels in normal livers. Except for one chaperone, the level of upregulation did not correlate with the serum's HCV-RNA titre: the only difference between Group1 and 2 (RNA titre above and below 8.78 106 respectively) was that the level of ATF6 was 1.6 times higher in Group1 compared to Group2. The expression of all chaperones was reduced, and some even became downregulated after the interferon treatment. In accordance with the literature our results suggest that hepatitis C might induce apoptosis through ER-stress. Those cells exposed to a high C viral load, had a lower chance to be eliminated.
MR imaging FOLLOW UP after MR-guided Focused Ultrasound Surgery for uterine leiomyomas — Early and mid term results
Authors: Várallyay Csanád , Balázs György , Lénárd Zsuzsanna , Bérczi Viktor , Belics Zorán , Bajzik Gábor , Wragg Paul , Hüttl Kálmán , Jolesz Ferenc 
Published: March 2010

Abstract

Rationale and Objectives: MR-guided Focused Ultrasound Surgery (MRgFUS) is an evolving thermoablative technique for treatment of benign and malignant soft tissue tumors. The feasibility and effectiveness of this non-invasive method has been tested by several investigators by treating uterine fibroid. The aim of the present study was to evaluate early and mid-term efficacy of MRgFUS treatment using MR imaging follow-ups. Materials and Methods: 38 patients with uterine fibroids were enrolled and treated by MRgFUS in a single center. MRI follow-up exams were performed 3 and 6 months after the procedure. Total fibroid volumes (FV) and non-perfused volumes (NPV) were compared and evaluated over time. Results: There was a significant reduction of FV at 3- and 6-month follow-ups (10±19%, p=0.022 and 19±29%, p<0.001, respectively). In the subgroup of fibroids smaller than 5.4 cm in diameter a 35±18% volume reduction was found after 6 months. There was also a positive correlation found between the early NPV and the FV decrease at 3- and 6-months follow-ups. Conclusion: This study suggests that MRgFUS can effectively coagulate uterine fibroid tissue. Smaller UFs can be most effectively treated within reasonable time with the used equipment.
Determination of coronary in-stent restenosis using dual source computed tomography angiography
Authors: Szelid Zsolt , Kerecsen G. , Maurovich-Horvat P. , Lux Á. , Marosi E. , Kovács A. , Kiss R. G. , Préda I. , Merkely B. 
Published: March 2010

AbstractDiagnostic accuracy of 64-slice CT angiography in the evaluation of in-stent restenosis is improved compared to previous CT methods. The image quality and exact diagnostic performance is, however, limited by several method, stent and patient-related factors. In this retrospective multicenter study the first results with dual source 64-slice scanner are presented in a Hungarian post PCI patient population (n=99). Radiation dose was 11.3±5.2 mSv (average±STD) using a helical scan. In 5.6% of all (n=142) examined stents clinicians were not able to give a final diagnosis using CT scan. This limitation showed correlation with the stent diameter. Nondiagnostic stents were smaller compared to the diagnostic stents (diameter 2.4±0.2 mm versus 3.2±0.5 mm, average±STD, respectively,P<0.01). Despite its high negative predictive value in the detection of restenosis, positive predictive value of CTA is lower, than that of invasive angiography. CT was not powerful enough in our study to distinguish vessel occlusion from severe restenosis. Heart rate was decreased by administration of intravenous metoprolol and in 75.8% of the patients scan was performed at a heart rate over 70 beats/minute, which did not have a significant influence on the diagnostic value.
Influence of thiopental on MAPK and NF-κB activation in A549 cells
Authors: Bundy R. E. , Falusi B. , Marczin Nandor 
Published: March 2010

Abstract
Thiopental (TP) along with being an intravenous anaesthetic is frequently used in high doses to treat increased intracranial hypertension. Long-term treatments result in its accumulation in the lungs and an increased incidence of nosocomial infections. Since TP has been shown to modulate TNF-induced inflammatory pathways in lymphocytes, we hypothesised that TP may modulate pro-inflammatory events in human pulmonary epithelial cells. We investigated the potential influence of TP on MAPK and NF-κB signal transduction pathways in the absence and presence of TNF. TP at 1 mg/ml concentrations produced a 10-fold increase in p38 activation as assessed by Western blotting using monoclonal antibodies specific for double phosphorylated, thereby activated form of p38. This increase in p38 MAPK phosphorylation was evident as early as 10 minutes (4.5-fold), peaked at 60 minutes (11.3-fold) with return towards baseline (3.6-fold) in 2 hours. This response was specific for p38, since there was no evidence for activation of NF-κB pathway by TP as judged from Western blot analysis of steady-state IκB levels. TNF activated both p38 (2.4–11.4-fold increases) and depleted IκB (64–35% of control) in a concentration dependent manner (0.1–10 ng/ml). Interestingly, in the presence of TP, TNF did not produce a further increase in p38 activation. In addition, TP tended to attenuate TNF-induced NF-κB activation. These data suggest that high dose TP has the capacity to specifically alter p38MAPK activation and to modulate TNF signalling in epithelial cells, which might have implications to immunological responses in the lung.
Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood Lymphocytes
Authors: Acharya Santhosh , Sanjeev Ganesh , Bhat Nagesh , Narayana Yerol 
Published: March 2010

Dose Rate Effect of Pulsed Electron Beam on Micronucleus Frequency in Human Peripheral Blood LymphocytesThe micronucleus assay in human peripheral blood lymphocytes is a sensitive indicator of radiation damage and could serve as a biological dosimeter in evaluating suspected overexposure to ionising radiation. Micronucleus (MN) frequency as a measure of chromosomal damage has also extensively been employed to quantify the effects of radiation dose rate on biological systems. Here we studied the effects of 8 MeV pulsed electron beam emitted by Microtron electron accelerator on MN induction at dose rates between 35 Gy min-1 and 352.5 Gy min-1. These dose rates were achieved by varying the pulse repetition rate (PRR). Fricke dosimeter was employed to measure the absorbed dose at different PRR and to ensure uniform dose distribution of the electron beam. To study the dose rate effect, blood samples were irradiated to an absorbed dose of (4.7±0.2) Gy at different rates and cytogenetic damage was quantified using the micronucleus assay. The obtained MN frequency showed no dose rate dependence within the studied dose rate range. Our earlier dose effect study using 8 MeV electrons revealed that the response of MN was linear-quadratic. Therefore, in the event of an accident, dose estimation can be made using linear-quadratic dose response parameters, without adding dose rate as a correction factor.