bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamebrics: Design, implementation and practical evaluation of analytical rubrics in serious game play
Authors: Hummel Hans G. K. , Nadolski Rob , Huurdeman Hugo , van Lankveld Giel , Georgiadis Konstantinos , Slootmaker Aad , Kurvers Hub , Hummel Mick , Neessen Petra , van den Boomen Johan , Pat‐El Ron , Fischmann Julia 
Published: May 2024

AbstractBackgroundComplex skills, like analytical thinking, are essential in preparing students for future professions. Serious games hold potential to stimulate the online acquisition of such professional skills in an active and experiential way.ObjectiveRubrics are proven assessment and evaluation instruments, but were never directly integrated into actual gameplay. We present our approach towards the integration of analytical rubrics into gameplay, the implementation into existing (scenario‐based) serious games, and main findings from a study on learning effects and appreciation of the tooling (dashboard with progress information and reflective feedback).MethodOur experimental research setup randomly allocated 84 participating students into either a control group or an experimental group. The intervention for the control group consisted of an existing serious game with natural feedback as part of the scenario, supporting the gameplay itself. The intervention for the experimental group also provided an additional dashboard with reflective feedback, monitoring the acquisition of analytical skills through gameplay. Learning growth through gameplay was measured by pre‐/post‐test scores on a knowledge test, in‐game performance by means of computer logging, and appreciation of the dashboard and feedback by means of a questionnaire.Results and ConclusionsParticipants receiving reflective feedback show higher learning increases (on a pre‐/post‐knowledge test), and more efficient gameplay behaviour (on performance scores). Participants receiving reflective feedback feel more confident about competence development. These findings appear promising for this approach on integrating formative assessment in serious gameplay to support the acquisition of complex skills.
Mechanism of Astragalus membranaceus (Huangqi, HQ) for treatment of heart failure based on network pharmacology and molecular docking
Authors: Chen Qiuxiang , Wang Juan , Sun Lihua , Ba Bayinsilema , Shen Difei 
Published: May 2024

AbstractHeart failure is a leading cause of death in the elderly. Traditional Chinese medicine, a verified alternative therapeutic regimen, has been used to treat heart failure, which is less expensive and has fewer adverse effects. In this study, a total of 15 active ingredients of Astragalus membranaceus (Huangqi, HQ) were obtained; among them, Isorhamnetin, Quercetin, Calycosin, Formononetin, and Kaempferol were found to be linked to heart failure. Ang II significantly enlarged the cell size of cardiomyocytes, which could be partially reduced by Quercetin, Isorhamnetin, Calycosin, Kaempferol, or Formononetin. Ang II significantly up‐regulated ANP, BNP, β‐MHC, and CTGF expressions, whereas Quercetin, Isorhamnetin, Calycosin, Kaempferol or Formononetin treatment partially downregulated ANP, BNP, β‐MHC and CTGF expressions. Five active ingredients of HQ attenuated inflammation in Ang II‐induced cardiomyocytes by inhibiting the levels of TNF‐α, IL‐1β, IL‐18 and IL‐6. Molecular docking shows Isorhamnetin, Quercetin, Calycosin, Formononetin and Kaempferol can bind with its target protein ESR1 in a good bond by intermolecular force. Quercetin, Calycosin, Kaempferol or Formononetin treatment promoted the expression levels of ESR1 and phosphorylated ESR1 in Ang II‐stimulated cardiomyocytes; however, Isorhamnetin treatment had no effect on ESR1 and phosphorylated ESR1 expression levels. In conclusion, our results comprehensively illustrated the bioactives, potential targets, and molecular mechanism of HQ against heart failure. Isorhamnetin, Quercetin, Calycosin, Formononetin and Kaempferol might be the primary active ingredients of HQ, dominating its cardioprotective effects against heart failure through regulating ESR1 expression, which provided a basis for the clinical application of HQ to regulate cardiac hypertrophy and heart failure.
Short‐chain fatty acids: bridges between diet, gut microbiota, and health
Authors: Wang Ling‐Yun , He Li‐Hong , Xu Li‐Jun , Li Shi‐Bo 
Published: May 2024

AbstractIn recent years, gut microbiota has become a hot topic in the fields of medicine and life sciences. Short‐chain fatty acids (SCFAs), the main metabolites of gut microbiota produced by microbial fermentation of dietary fiber, play a vital role in healthy and ill hosts. SCFAs regulate the process of metabolism, immune, and inflammation and have therapeutic effects on gastrointestinal and neurological disorders, as well as antitumor properties. This review summarized the production, distribution, and molecular mechanism of SCFAs, as well as their mechanisms of action in healthy and ill hosts. In addition, we also emphasized the negative effects of SCFAs, aiming to provide the public with a more comprehensive understanding of SCFAs.
Nephrologists' perspectives and experiences with hospice among older adults with end‐stage kidney disease
Authors: Wachterman Melissa W. , Sinha Anupallavi , Leveille Tarikwa , Waikar Sushrut S. , Widera Eric , Romero Kai , Bokhour Barbara 
Published: May 2024

AbstractBackgroundHospice care leads to improved patient and family outcomes. Hospice use among older adults with end‐stage kidney disease (ESKD) is markedly lower than among older adults with other serious illnesses, and the majority of those with ESKD who use hospice enroll in the last days of life. Here, our aim was to explore barriers to timely receipt of high‐quality hospice care for older adults with ESKD.MethodsUtilizing a qualitative study design, we conducted a secondary analysis focused on hospice, a theme that we identified in our larger overarching study that involved semi‐structured interviews with 20 nephrologists in the United States focused on treatment decision‐making in older adults with advanced chronic kidney disease. We analyzed the interview transcripts using emergent thematic analysis to develop an understanding of barriers to high‐quality hospice.ResultsWith a couple notable exceptions, nephrologists voiced general support for the concept of hospice, but few recalled patients of theirs who had received hospice. Nephrologists' interviews revealed two interrelated contributors to the lack of timely access to high‐quality hospice care for seriously ill older adults with ESKD: (1) nephrologists view dialysis and hospice as mutually exclusive models of care; (2) nephrologists feel unsure who should manage hospice care for patients with ESKD. The first contributor was rooted in nephrologists' narrow vision of when to consider hospice (informed, in part, by policy barriers) and, in a couple of cases, strong discomfort with hospice. The second stemmed from nephrologists' belief that neither they nor hospice are adequately prepared to provide hospice care for ESKD.ConclusionsOur findings suggest that, in addition to Medicare policy change, nephrologists need to receive more training in primary palliative care skills including in indications for hospice, initiating conversations about hospice with patients, and collaborating with hospice clinicians to care for these vulnerable patients.
‘There is just nothing to hold on to in this case’: legal technicalities and the use of psychological reports in Chilean domestic violence procedures
Authors: RIQUELME ESPINOSA IGNACIO 
Published: May 2024

AbstractThis ethnographic study examines how Chilean family courts adjudicate domestic violence (DV) cases, highlighting a paradoxical shift away from their intended flexibility towards rigid bureaucratic procedure by examining the undue influence of psychological reports, which are expensive and difficult‐to‐obtain documents, on case outcomes. This research explores the role of these reports as ‘legal technicalities’, serving as both products and catalysts of specific social relations and tensions, and reveals an earnest yet unsuccessful effort to establish judicial authority amid poorly conceived DV reform. The article contributes to an empirical, bottom‐up analysis of authority construction techniques used in recent widespread judicial reforms in Chile, providing fresh insights into the complexities of institutional changes within these contexts.
Gastroschisis and septo‐optic‐pituitary dysplasia: Is there an association?
Authors: Salman Michael S , Ruth Chelsea A , Yogendran Marina S , Zrinyi Anna , Morris Melanie 
Published: May 2024

AimThere are several case reports describing patients with both optic nerve hypoplasia/septo‐optic‐pituitary dysplasia (ONH/SOD) and gastroschisis (GS). Our aim was to investigate whether ONH/SOD is associated with GS.MethodsA retrospective population‐based study was undertaken using the Population Research Data Repository at the Manitoba Center for Health Policy in Manitoba, Canada to investigate if any patient with ONH/SOD also had GS. In addition, Winnipeg's Surgical Database of Outcomes and Management (WiSDOM), a hospital‐based paediatric surgical database, was searched to ascertain if any of the patients with GS also have ONH/SOD.ResultsCases were 124 patients with ONH/SOD diagnosed during 1990–2019. None had GS. The surgical database had 188 patients from Manitoba with GS during 1991–2019. None had ONH/SOD.ConclusionThere does not appear to be an association between ONH/SOD and GS in our cohorts of patients with these two disorders.
Melatonin restores hepatic lipid metabolic homeostasis disrupted by blue light at night in high‐fat diet‐fed mice
Authors: Guan Qingyun , Wang Zixu , Cao Jing , Dong Yulan , Tang Shusheng , Chen Yaoxing 
Published: May 2024

AbstractArtificial light at night (ALAN) is an emerging environmental pollutant that threatens public health. Recently, ALAN has been identified as a risk factor for obesity; however, the role of ALAN and its light wavelength in hepatic lipid metabolic homeostasis remains undetermined. We showed that chronic dim (~5 lx) ALAN (dLAN) exposure significantly promoted hepatic lipid accumulation in obese or diabetic mice, with the most severe effect of blue light and little effect of green or red light. These metabolic phenotypes were attributed to blue rather than green or red dLAN interfering with hepatic lipid metabolism, especially lipogenesis and lipolysis. Further studies found that blue dLAN disrupted hepatic lipogenesis and lipolysis processes by inhibiting hepatic REV‐ERBs. Mechanistically, feeding behavior mediated the regulation of dLAN on hepatic REV‐ERBs. In addition, different effects of light wavelengths at night on liver REV‐ERBs depended on the activation of the corticosterone (CORT)/glucocorticoid receptor (GR) axis. Blue dLAN could activate the CORT/GR axis significantly while other wavelengths could not. Notably, we demonstrated that exogenous melatonin could effectively inhibit hepatic lipid accumulation and restore the hepatic GR/REV‐ERBs axis disrupted by blue dLAN. These findings demonstrate that dLAN promotes hepatic lipid accumulation in mice via a short‐wavelength‐dependent manner, and exogenous melatonin is a potential therapeutic approach. This study strengthens the relationship between ALAN and hepatic lipid metabolism and provides insights into directing ambient light.
Specialist nurse's health promotion work with the national childhood immunization programme: A qualitative study
Authors: Aradottir Louis , Wellman Linnea , Göransson Carina 
Published: May 2024

AbstractPurposeChildhood immunizations have proven to be one of the most beneficial interventions to promote public health and prevent childhood deaths due to disease. However, global coverage of childhood immunization has decreased throughout the world due to guardians' growing hesitancy towards immunizations. This study aims to describe how specialist nurses promote legal guardians to adhere to national childhood immunization programmes.Design and MethodsThis study had a qualitative design. Semistructured interviews with 11 specialist nurses, who were paediatric primary care nurses or nurse practitioners, were conducted. Data were analysed using qualitative content analysis.ResultsThe findings, with four main categories including four subcategories, showed nurses using both local guidelines and national guidelines to promote guardians to adhere to the childhood immunization programme. The main intervention the nurses did to promote childhood immunization coverage was giving legal guardians general information about the programme. With hesitant guardians, adopting a person‐centred approach towards the legal guardian improved adherence.Practice ImplicationsFurther research should focus on how specialist nurses can respond to guardians who decline immunization for their children, as this study identified difficulties in this area. Furthermore, research on guardians' perspectives towards childhood immunization may also help generate further effective guidance on how to promote immunization coverage among children.
ACVIM consensus statement on the treatment of immune thrombocytopenia in dogs and cats
Authors: LeVine Dana N. , Goggs Robert , Kohn Barbara , Mackin Andrew J. , Kidd Linda , Garden Oliver A. , Brooks Marjory B. , Eldermire Erin R. B. , Abrams‐Ogg Anthony , Appleman Elizabeth H. , Archer Todd M. , Bianco Domenico , Blois Shauna L. , Brainard Benjamin M. , Callan Mary Beth , Fellman Claire L. , Haines Jillian M. , Hale Anne S. , Huang Alice A. , Lucy John M. , O'Marra Shana K. , Rozanski Elizabeth A. , Thomason John M. , Walton Jenny E. , Wilson Helen E. 
Published: May 2024

AbstractManagement of immune thrombocytopenia (ITP) in dogs and cats is evolving, but there are no evidence‐based guidelines to assist clinicians with treatment decisions. Likewise, the overall goals for treatment of ITP have not been established. Immunosuppressive doses of glucocorticoids are the first line treatment, but optimal treatment regimens beyond glucocorticoids remain uncertain. Additional options include secondary immunosuppressive drugs such as azathioprine, modified cyclosporine, and mycophenolate mofetil, usually selected based on clinician preference. Vincristine, human IV immunoglobulin (hIVIg), and transfusion of platelet or red blood cell–containing products are often used in more severe cases. Splenectomy and thrombopoietin receptor agonists are usually reserved for refractory cases, but when and in which patient these modalities should be employed is under debate. To develop evidence‐based guidelines for individualized treatment of ITP patients, we asked 20 Population Intervention Comparison Outcome (PICO) format questions. These were addressed by 17 evidence evaluators using a literature pool of 288 articles identified by a structured search strategy. Evidence evaluators, using panel‐designed templates and data extraction tools, summarized evidence and created guideline recommendations. These were integrated by treatment domain chairs and then refined by iterative Delphi survey review to reach consensus on the final guidelines. In addition, 19 non‐PICO questions covering scenarios in which evidence was lacking or of low quality were answered by expert opinion using iterative Delphi surveys with panelist integration and refinement. Commentary was solicited from multiple relevant professional organizations before finalizing the consensus. The rigorous consensus process identified few comparative treatment studies, highlighting many areas of ITP treatment requiring additional studies. This statement is a companion manuscript to the ACVIM Consensus Statement on the Diagnosis of Immune Thrombocytopenia in Dogs and Cats.
Understanding mesopredator responses to changes in apex predator populations in Europe: implications for the mesopredator release hypothesis
Authors: van Schaik Thomas , van Kuijk Marijke , Sterck Elisabeth H. M. 
Published: May 2024

Abstract

Conservation successes in Europe have sparked the recovery of apex predators, which may affect the populations of mesopredators. The mesopredator release hypothesis (MRH) predicts that a decline in apex predators triggers a ‘release’ of mesopredators from suppression.
We expanded the MRH to include predictions of inverse responses following increases in apex predator abundance or distribution. We examined European mesopredator responses to changes in apex predator populations and evaluated the extended MRH's explanatory power.
We examined the results of 47 studies on European predators for supporting evidence, mixed evidence, no evidence, or contrasting evidence for the extended MRH.
Out of 38 apex predator – mesopredator pairings, 10 predominantly supported the extended MRH, while others provided limited or no support. In 23 instances across 17 pairings, mesopredator responses contradicted predictions. Initial findings suggest the extended MRH better predicts mesopredator responses in pairings with intermediate to large body size differences and in pairings where mesopredators primarily hunt.
Our results reveal non‐uniform mesopredator responses to changing apex predator populations. This emphasises the complexity of predator interactions, which extends beyond suppression. We suggest the MRH's scope is more restricted than previously thought, cautioning against overreliance on the MRH as a default expectation for European mesopredator responses to apex predator population changes.
Compositional evidence for chondrule origins of low‐Ca pyroxenes in comet Wild 2 and a giant cluster IDP
Authors: Joswiak D. J. , Brownlee D. E. , Westphal A. J. , Gainsforth Z. , Zhang M. , Kita N. T. 
Published: May 2024

AbstractA literature compilation of 1136 low‐Ca pyroxene compositions from chondrules from 12 primitive type 2–3 carbonaceous, ordinary and enstatite chondrite groups define unique regions on an Al2O3 and Cr2O3 diagram when compared to low‐Ca pyroxenes from equilibrated type 4‐6 chondrites. Measured compositions of 100 low‐Ca pyroxenes from comet Wild 2 and a giant cluster IDP of probable cometary origin are similar to each other and fall in the type 2–3 chondrite chondrule region suggesting that most of the pyroxenes likely formed in the solar nebula like conventional chondrules. The data imply that most low Ca‐pyroxenes from comet Wild 2 and the giant cluster IDP formed from igneous crystallization processes and did not experience significant thermal metamorphism, indicating that the low‐Ca pyroxenes were unlikely incorporated into large parent bodies prior to accretion in their respective comet bodies. An intriguing group of nine low‐Ca pyroxenes from comet Wild 2 with low Cr and Al that fall where type 4–6 chondrites are located are interpreted as products of condensation. The compositional data combined with previously measured oxygen isotopes on 17 low‐Ca pyroxenes support earlier conclusions that comet samples have links with carbonaceous, ordinary, and possibly enstatite chondrite groups. Our results provide additional evidence that comets accreted materials from multiple chondrule reservoirs throughout the solar nebula.
Understanding adherence to continuous positive airway pressure in patients with obstructive sleep apnea post‐stroke: A prospective study based on the Andersen model
Authors: Yang Hua‐Lu , Wang Mian , Xu Yan‐Fei , Mo Bei‐Rong , Liu Xian‐Liang , Redding Sharon R. 
Published: May 2024

AbstractAdherence to continuous positive airway pressure (CPAP) in patients with obstructive sleep apnea (OSA) post‐stroke is often problematic, despite potential benefits. This study aimed to evaluate CPAP adherence in patients with OSA post‐stroke based on the Andersen behavioral model of health services utilization. A total of 227 eligible participants were recruited from a Chinese hospital. After baseline assessment, participants were followed for 6 months to determine short‐term CPAP adherence. Those with good short‐term adherence were followed for an additional 6 months to explore long‐term adherence and influencing factors. Short‐term CPAP adherence rate was 33%. Being married or living with a partner, having an associate degree or baccalaureate degree or higher, and stronger health beliefs independently predicted short‐term CPAP adherence. Only 25% of participants from the adherent group showed good long‐term adherence. The factor associated with long‐term CPAP adherence was participants not using alcohol. Adherence to CPAP is suboptimal among patients having OSA post‐stroke. Addressing unfavorable predisposing factors and modifying health beliefs are suggested.
‘I didn't know it was you’: The impersonal grounds of relational normativity
Authors: Lewinsohn Jed 
Published: May 2024

AbstractA notable feature of our moral and legal practices is the recognition of privileges, powers, and entitlements belonging to a select group of individuals in virtue of their status as victims of wrongful conduct. A philosophical literature on relational normativity purports to account for this status in terms of such notions as interests, rights, and attitudes of disregard. This paper argues that such individualistic notions cannot account for prevailing and intuitive ways of demarcating the class of victims. The paper is focused on the wrongful infliction of harm, and centers on the mediating role played by impersonal “danger‐making properties” in the determination of the class of victims. The paper begins with an analysis of one of the most well‐ known discussions of negligently‐inflicted harm — from the most famous case of the American common law tradition, Palsgraf v. Long Island Railroad Co. — and the analysis is then extended to the morality of harm‐doing more broadly, negligent and intentional alike. The paper's chief targets are interest theories of rights — including contractualist theories of moral claim‐rights of the kind defended by R. Jay Wallace — and neo‐Strawsonian Quality of Will theories of “moral injury”.
A qualitative, multi‐perspective study on causal beliefs about adolescent depression
Authors: Wentholt Wilma G. M. , Janssen Loes H. C. , van Houtum Lisanne A. E. M. , Wever Mirjam C. M. , Tollenaar Marieke S. , Alink Lenneke R. A. , Elzinga Bernet M. 
Published: May 2024

AbstractObjectivesThe current study aimed to examine: (1.1) causal beliefs about adolescent depression in a sample of adolescents with a clinical depression and their mothers and fathers; (1.2) within‐family overlap of causal beliefs; (2.1) mothers' and fathers' reflected causal beliefs about their child's perspective; (2.2) the accuracy of mothers' and fathers' reflected causal beliefs as related to their child's causal beliefs.DesignQualitative study using a within‐family approach.MethodsAdolescents with a current clinical depression (MDD/dysthymia; N = 34) and their parents (N = 34 mothers, N = 26 fathers) were independently interviewed about their causal beliefs about the adolescents' depression. Parents were additionally interviewed about their perception of their child's causal beliefs (i.e., reflected causal beliefs).ResultsThe causal beliefs most frequently mentioned by adolescents, mothers and fathers are: characteristics of the child, social factors, school and various stressful experiences. Parent–child overlap was relatively low, specifically for the themes of bewilderment, cumulative effect and stressful life events, whereas overlap was relatively high for themes of social factors, school and stressful experiences outside of the family. Parents were relatively accurate in their reflected causal beliefs, but tended to underestimate their child's insights into possible causes of their depression. Accuracy of parents' reflected causal beliefs was particularly low for the theme cumulative effect and high for social factors.ConclusionsThe various causal beliefs of adolescents and their parents could be used in therapeutic setting. Future research could examine whether (guided) conversations may promote alignment within families and treatment efficacy.