bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mean full‐depth summer circulation and transports at the northern periphery of the Atlantic Ocean in the 2000s
Authors: Sarafanov Artem , Falina Anastasia , Mercier Herlé , Sokov Alexey , Lherminier Pascale , Gourcuff Claire , Gladyshev Sergey , Gaillard Fabienne , Daniault Nathalie 
Published: November 2011

A mean state of the full‐depth summer circulation in the Atlantic Ocean in the region in between Cape Farewell (Greenland), Scotland and the Greenland‐Scotland Ridge (GSR) is assessed by combining 2002–2008 yearly hydrographic measurements at 59.5°N, mean dynamic topography, satellite altimetry data and available estimates of the Atlantic–Nordic Seas exchange. The mean absolute transports by the upper‐ocean, mid‐depth and deep currents and the Meridional Overturning Circulation (MOCσ = 16.5 ± 2.2 Sv, at σ0= 27.55) at 59.5°N are quantified in the density space. Inter‐basin and diapycnal volume fluxes in between the 59.5°N section and the GSR are then estimated from a box model. The dominant components of the meridional exchange across 59.5°N are the North Atlantic Current (NAC, 15.5 ± 0.8 Sv,σ0 < 27.55) east of the Reykjanes Ridge, the northward Irminger Current (IC, 12.0 ± 3.0 Sv) and southward Western Boundary Current (WBC, 32.1 ± 5.9 Sv) in the Irminger Sea and the deep water export from the northern Iceland Basin (3.7 ± 0.8 Sv, σ0 > 27.80). About 60% (12.7 ± 1.4 Sv) of waters carried in the MOCσ upper limb (σ0< 27.55) by the NAC/IC across 59.5°N (21.1 ± 1.0 Sv) recirculates westward south of the GSR and feeds the WBC. 80% (10.2 ± 1.7 Sv) of the recirculating NAC/IC‐derived upper‐ocean waters gains density ofσ0 > 27.55 and contributes to the MOCσlower limb. Accordingly, the contribution of light‐to‐dense water conversion south of the GSR (∼10 Sv) to the MOCσ lower limb at 59.5°N is one and a half times larger than the contribution of dense water production in the Nordic Seas (∼6 Sv).
Preventing hereditary cancers caused by opportunistic carcinogens
Authors: Friedenson Bernard 
Published: November 2011

Abstract
Objectives
Previous studies reported inherited BRCA1/2 deficits appear to cause cancer by impairing normal protective responses to some carcinogens. Opportunistic carcinogens can exploit these deficits by causing chronic inflammation, constant cell death and replacement in a mutagenic environment, DNA crosslinking or double strand breaks. Some of the resulting cancers may be prevented if BRCA1/2 specific carcinogens are identified.

Methods
The literature was systematically searched for carcinogens capable of exploiting deficits in BRCA1/2 pathways. Search criteria were common exposure, available information, required BRCA1/2 pathway repairs, increased risks for any cancer, and effects on stem cells.

Results
Formaldehyde and acetaldehyde are closely related carcinogens and common pollutants that are everywhere. Alcohol metabolism also produces acetaldehyde. High levels of either carcinogen overwhelm normal detoxification systems, cause inflammation, inhibit DNA repair and produce DNA cross links as critical carcinogenic lesions. Searching model system studies revealed both carcinogens activate stem cells, BRCA1/2 pathways and connected BRCA1/2 pathways to myeloid leukemia. For example, the BRCA1-BARD1 complex is required for proper nucleophosmin functions. Nucleophosmin prevents a major subset of acute myeloid leukemia (AML). Next, these concepts were independently tested against risks for myeloid leukemia. Epidemiologic results showed that BRCA2 gene defects inherited on both chromosomes increased risks so dramatically that AML occurs in most children. Using data from 14 studies, known/potential heterozygous BRCA1/BRCA2 mutations increased risks for myeloid leukemias by at least 3 fold in 7 studies and by at least 50% in 12.Acetaldehyde occurs in breast milk. In model studies, excessive acetaldehyde/alcohol exposure affects estrogen metabolism and stimulates alternate alcohol detoxification pathways.These pathways can cause DNA cross linking by releasing oxygen species and activating procarcinogens. Acetaldehyde in rats’ drinking water increased incidence of leukemias, lymphomas,pancreatic cancers and fibroadenomas. Human epidemiologic studies showed increased premenopausal breast cancer risks associated with persistent/high acetaldehyde levels related to alcohol metabolism genotype.

Conclusions
Although it is difficult to prove direct causation, BRCA1/2 mutation carriers may reduce cancer risks by avoiding excessive formaldehyde and acetaldehyde
Oxidation of Met1606 in von Willebrand factor is a risk factor for thrombotic and septic complications in chronic renal failure
Authors: De Filippis Vincenzo , Lancellotti Stefano , Maset Fabio , Spolaore Barbara , Pozzi Nicola , Gambaro Giovanni , Oggianu Laura , Calò Lorenzo A. , De Cristofaro Raimondo 
Published: November 2011

CKD (chronic kidney disease) is a life-threatening pathology, often requiring HD (haemodialysis) and characterized by high OS (oxidative stress), inflammation and perturbation of vascular endothelium. HD patients have increased levels of vWF (von Willebrand factor), a large protein (~240 kDa) released as UL-vWF (ultra large-vWF polymers, molecular mass ~20000–50000 kDa) from vascular endothelial cells and megakaryocytes, and responsible for the initiation of primary haemostasis. The pro-haemostatic potential of vWF increases with its length, which is proteolytically regulated by ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin motifs 13), a zinc-protease cleaving vWF at the single Tyr1605–Met1606 bond, and by LSPs (leucocyte serine proteases), released by activated PMNs (polymorphonuclear cells) during bacterial infections. Previous studies have shown that in vitro oxidation of Met1606 hinders vWF cleavage by ADAMTS-13, resulting in the accumulation of UL-vWF that are not only more pro-thrombotic than shorter vWF oligomers, but also more efficient in binding to bacterial adhesins during sepsis. Notably, HD patients have increased risk of developing dramatic cardiovascular and septic complications, whose underlying mechanisms are largely unknown. In the present study, we first purified vWF from HD patients and then chemically characterized its oxidative state. Interestingly, HD-vWF contains high carbonyl levels and increased proportion of UL-vWF polymers that are also more resistant to ADAMTS-13. Using TMS (targeted MS) techniques, we estimated that HD-vWF contains &gt;10% of Met1606 in the sulfoxide form. We conclude that oxidation of Met1606, impairing ADAMTS-13 cleavage, results in the accumulation of UL-vWF polymers, which recruit and activate platelets more efficiently and bind more tightly to bacterial adhesins, thus contributing to the development of thrombotic and septic complications in CKD.
Role of Fur on cyanide tolerance of Pseudomonas pseudoalcaligenes CECT5344
Authors: Becerra Gracia , Blasco Rafael , Quesada Alberto , Merchán Faustino , Igeño M. Isabel 
Published: November 2011

Pseudomonas pseudoalcaligenes CECT5344 can be used in cyanide bioremediation processes because it grows at pH 9.5 using 2.0 mM cyanide at the sole nitrogen source. Cyanide strongly binds to metals creating iron-deprivation conditions. The bacterium responds to the presence of cyanide by inducing several processes such as siderophore synthesis for iron capture, cyanide-insensitive respiration system and defence mechanisms against oxidative stress. Since high concentrations of cyanide cause iron deficiency and because iron is an essential nutrient, bacterial growth in the presence of cyanide requires an efficient iron uptake. Fur is a global transcription factor that regulates a diversity of biological processes such as iron homoeostasis, TCA (tricarboxylic acid) cycle metabolism and oxidative stress response. Fur's regulation of iron uptake and storage genes should play a significant role in the lives of these bacteria. In the present review, current knowledge of Fur is summarized.
Mutation-induced fold switching among lattice proteins
Authors: Holzgräfe Christian , Irbäck Anders , Troein Carl 
Published: November 2011

Recent experiments uncovered a mutational pathway between two proteins, along which a single mutation causes a switch in fold. Searching for such paths between real proteins remains, despite this achievement, a true challenge. Here, we analyze fold switching in the minimalistic hydrophobic/polar model on a square lattice. For this analysis, we generate a comprehensive sequence-structure database for chains of length ⩽ 30, which exceeds previous work by five units. Single-mutation-induced fold switching turns out to be quite common in the model. The switches define a fold network, whose topology is roughly similar to what one would expect for a set of randomly connected nodes. In the combinatorially challenging search for fold switches between two proteins, a tempting strategy is to only consider paths containing the minimum number of mutations. Such a restricted search fails to correctly identify 40% of the single-mutation-linked fold pairs that we observe. The thermodynamic stability is correlated with mutational stability and is, on average, markedly reduced at the observed fold switches.
Statistical Analysis and the OPEA Model of the White-Light Flares Occurring on Krüger 60B (DO Cep)
Authors: Dal Hasan Ali 
Published: November 2011

AbstractIn this study, new observations and some results of statistical analyses are presented. The largest flare data set of DO Cep in the literature has been obtained with 89 flares detected in 67.61 hours ofU-band flare patrol. First of all, the observations demonstrated that the star is one of the most active flare stars in respect to the computed flare frequency. Secondly, using the independent samplest-test, the detected flares were classified into two subtypes, and then they were modelled. Analysing the models demonstrated that the fast and slow flares occurring on the star can be separated with a critical value of the ratio of their decay time to rise time. The critical value was computed as 3.40. According to this value, the fast flare rate is 20.22%, while the slow flare rate is 79.78%. Besides, there is a 39.282 times difference between the energies of these two types of flares. However, the flare equivalent durations versus the flare rise times increase in similar ways for both groups. In addition, all the flares were modelled with the one-phase exponential association function. Analysing this model, theplateauvalue was found to be 2.810. Moreover, thehalf-lifevalue was computed as 433.1 s from the model. The maximum flare rise time was found to be 1164 s, while the maximum flare total duration was found to be 3472 s. The results of the flare timescales indicate that the geometry of the flaring loop on the surface of the star might be similar to those seen on analogues of DO Cep. Consequently, considering both the half-life value and flare timescales, the flares detected on the surface of DO Cep get maximum energy in longer times, while the geometries of the flaring loops or areas get smaller.
Living U.S. Capitalism: The Normalization of Credit/Debt
Authors: Peñaloza Lisa , Barnhart Michelle 
Published: November 2011

Abstract
This research develops a theoretical account of cultural meanings as integral mechanisms in the normalization of credit/debt. Analysis derives these meanings from the credit/debt discourses and practices of 27 white middle-class consumers in the United States and tracks their negotiation in patterns and trajectories in social and market domains. Discussion elaborates the ways informants normalize credit/debt in transposing their categories, in improvising meaning combinations, and in suturing the meaning patterns to particular subject positions in constituting themselves as consumers. Theoretical contributions (1) distinguish consumers’ collaborative production of cultural meanings with friends, family, and others in the social domain and with financial agents and institutions in the market domain and (2) document the productive capacities of these meanings in patterns and trajectories in configuring people as consuming subjects. Implications situate such cultural reproduction processes in the United States in discussing how the national legacy of abundance informs the normalization of credit/debt.
The Effect of Aging on the Chaperone Concentrations in the Hepatic, Endoplasmic Reticulum of Male Rats: The Possible Role of Protein Misfolding Due to the Loss of Chaperones in the Decline in Physiological Function Seen With Age
Authors: Erickson Richard R. , Dunning Lisa M. , Holtzman Jordan L. 
Published: November 2011

Abstract
The endoplasmic reticulum (ER) chaperones are highly conserved proteins that catalyze the posttranslational processing of all secretory and membrane proteins. Our studies suggest that chaperone declines are one of the two central defects in Alzheimer's disease. We propose that similar declines in other organ systems underlie the physiological deficits of aging. Rats were maintained in a colony from age 21 days to death. Animals were killed at regular intervals, and hepatic, ER chaperone contents were determined by immunoblotting. ERp55, ERp57, ERp72, BiP, and calnexin constitutive levels declined 30%–50% with age. Calreticulin was unaffected. BiP (also known as GRP78), ERp55, and ERp57 showed marked swings with peaks occurring in midwinter and midsummer. This cyclics declined 73% with age. Considering the role of the ER chaperones in membrane and secretory protein posttranslational processing, these data support the concept that their loss could lead to many of the physiological declines associated with aging.
Handgrip Strength Among Nonagenarians and Centenarians in Three European Regions
Authors: Jeune Bernard , Skytthe Axel , Cournil Amandine , Greco Valentina , Gampe Jutta , Berardelli Maurizio , Andersen-Ranberg Karen , Passarino Giuseppe , DeBenedictis Giovanna , Robine Jean-Marie 
Published: November 2011

Abstract
Background. Handgrip strength is an important predictor of disability and mortality among old people. The aim was to compare the grip strength among very old people in three regions of Europe.
Methods. In this substudy of the European Challenge for Healthy Aging project, only the long-lived probands were included. The maximum value of three measurements of handgrip strength was selected for the analysis. Adjustment for factors known to be correlated with grip strength was made by linear regression.
Results. Among 598 very old people (median age = 98 years) a clear North–South gradient was observed: For men, handgrip strength dropped from 24.2 kg in Southern Denmark to 20.8 kg in Languedoc-Roussillon, France and 14.2 kg in Calabria, Italy (p &lt;.0001), whereas for women the drop was smaller (from 12.2 to 9.2 kg; p =.0021). The difference remains significant after adjustment for age, gender, housing, knee height, Activities of Daily Living (ADL) scale score, score on the Six-Item Mini-Mental State Examination, chair stand, and number of age-related diseases, although these factors explain two thirds of the variation in handgrip strength.
Conclusions. Among nonagenarians and centenarians in three different European regions, we found a significant North–South gradient in handgrip strength with substantially lower values in Calabria. This finding may be due both to population background differences (e.g., genetic variations, birth weight, childhood growth) and to sociocultural differences (e.g., lifestyle, health care).
An Analysis of the Relationship Between Metabolism, Developmental Schedules, and Longevity Using Phylogenetic Independent Contrasts
Authors: Magalhães João Pedro de , Costa Joana , Church George M. 
Published: November 2011

AbstractComparative studies of aging are often difficult to interpret because of the different factors that tend to correlate with longevity. We used the AnAge database to study these factors, particularly metabolism and developmental schedules, previously associated with longevity in vertebrate species. Our results show that, after correcting for body mass and phylogeny, basal metabolic rate does not correlate with longevity in eutherians or birds, although it negatively correlates with marsupial longevity and time to maturity. We confirm the idea that age at maturity is typically proportional to adult life span, and show that mammals that live longer for their body size, such as bats and primates, also tend to have a longer developmental time for their body size. Lastly, postnatal growth rates were negatively correlated with adult life span in mammals but not in birds. Our work provides a detailed view of factors related to species longevity with implications for how comparative studies of aging are interpreted.
Stability of Sex Differences in Cognition in Advanced Old Age: The Role of Education and Attrition
Authors: Gerstorf Denis , Herlitz Agneta , Smith Jacqui 
Published: November 2011

Abstract
We examined whether patterns of sex differences on tasks of perceptual speed, episodic memory, verbal fluency, and verbal knowledge are maintained during advanced old age. Using incomplete 13-year longitudinal data from participants in the Berlin Aging Study screened for dementia (N = 368; M = 83 years; range 70–100 years at baseline assessment), we estimated sex-specific age trajectories of cognitive change and explored the contributing role of education and attrition. We found that women and men declined virtually in parallel, with no evidence of differential change. After we controlled for age cohort-related differences in education, women outperformed men on tasks in the four cognitive domains. Findings also provide initial evidence that sex differences might be masked by differential patterns of sample attrition.
Coping, Affect, and the Metabolic Syndrome in Older Men: How Does Coping Get Under the Skin?
Authors: Yancura Loriena A. , Aldwin Carolyn M. , Levenson Michael R. , Spiro Avron 
Published: November 2011

AbstractThe metabolic syndrome is a complex construct with interrelated factors of obesity, blood pressure, lipids, and glucose. It is a risk factor for a number of chronic diseases in late life. This study tested a model in which the relationship between stress and the metabolic syndrome was mediated by appraisal, coping, and affect. Data were collected from 518 male participants in the Normative Aging Study (X age = 68.17 years). The model was partially confirmed. Relationships among stress, appraisal, coping, and affect were valenced along positive and negative pathways. However, affect was not directly related to the metabolic syndrome. The metabolic syndrome was related to positive coping as operationalized by self-regulatory strategies. The results of this study suggest that the influence of coping on physical health may occur through emotional regulation.
Personality and Perceived Health in Older Adults: The Five Factor Model in Primary Care
Authors: Chapman Benjamin P. , Duberstein Paul R. , Sörensen Silvia , Lyness Jeffrey M. 
Published: November 2011

Abstract
Responses to specific questions tapping perceived health are associated with morbidity, mortality, and the use of health services, yet there has been little research on their personality correlates. We examined the associations between Five Factor Model personality traits and responses to four items extracted from the Medical Outcomes Study Short Form-36 in 266 primary care patients who were 65 years of age or older. Multivariate analyses controlling for age, gender, depressive symptoms, and physical disease burden showed that having a higher Neuroticism score was associated with worse perceived health in response to all items except “I am as healthy as anybody I know.” Having a lower Extraversion score was associated with worse perceived health in response to the item “I expect my health to get worse.” We discuss implications for understanding personality influences on morbidity, mortality, and health services utilization.
Effects of Balance Status and Age on Muscle Activation While Walking Under Divided Attention
Authors: Fraser Sarah A. , Li Karen Z. H. , DeMont Richard G. , Penhune Virginia B. 
Published: November 2011

Abstract
We examined the role of attention during different phases of the gait cycle by using a dual-task paradigm. Younger and older adults performed a self-paced treadmill walking task, a semantic judgment task, and both tasks simultaneously. We recorded vocal reaction time for the judgment task, and we recorded muscle activity by the use of electromyography. We derived dual-task costs from difference scores (single vs dual task). Our analysis of the judgment task showed that both groups responded more quickly during dual-task conditions than during single-task conditions. In five of eight muscle groups, stance-phase muscle activity decreased significantly from dual to single task. For older adults, individuals with poor balance increased their muscle activity during dual-task performance. These results suggest that, during moderately demanding walking and cognitive performance, poor balancers can compensate successfully for their motoric vulnerability.
Primary cicatricial alopecia: Recent advances in understanding and management
Authors: OHYAMA Manabu 
Published: November 2011

AbstractPrimary cicatricial alopecias (PCA) are a rare group of disorders, in which the hair follicle is the main target of destructive inflammation resulting in irreversible hair loss with scarring of affected lesions. The most typical clinical manifestation of PCA is the loss of visible follicular ostia. The histopathological hallmark of a fully developed lesion is the replacement of the hair follicle structure by fibrous tissue. PCA could share similar clinical manifestations and eventually lead to “burn‐out” alopecia. Some subsets are hardly distinguishable histopathologically and the mechanisms that elicit such a destructive reaction have not been fully elucidated. Thus, the management of PCA represents one of the most challenging clinical problems for dermatologists. The aim of this review is to provide a concise and comprehensive summary of recent advances in PCA management, especially focusing on novel methodologies to aid diagnosis, and updates on our understanding of the etiopathogenesis. Dermoscopy, a new pathological preparation technique and direct immunofluorescence analysis enable more accurate clinicopathological diagnosis of PCA. Microarray analysis may be beneficial to distinguish PCA subtypes. Currently suggested mechanisms underlying PCA include loss of immune protection of stem cells, impaired stem cell self‐maintenance, enhanced autoimmunity by pro‐inflammatory cytokines and environmental/genetic predispositions. Interestingly, recent data indicates the association between lipid metabolism dysregulation and PCA development, implying an important role of the sebaceous gland dysfunction in the etiopathogenesis. Based on that hypothesis and observations, novel therapeutic approaches have been proposed, including the use of peroxisome proliferator‐activated receptor‐γ agonist for lichen planopilaris.