bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interdiffusion in the formation of thin niobium films on singlecrystal silicon under vacuum annealing conditions
Authors: Afonin Nikolay N. , Logachova Vera A. 
Published: June 2024

For the design of technological process for creating device structures based on niobium and single-crystal silicon with thedesired properties, empirical and theoretical knowledge about the solid-phase interaction process in the system of a thin niobium film is required. The purpose of the research was a comprehensive study of the redistribution of components during the formation of thin niobium films on single-crystal silicon obtained by magnetron-assisted sputtering followed by vacuum annealing. The structure and phase composition were studied by X-ray phase analysis, scanning electron microscopy, and atomic force microscopy. Distribution of components along the depth was determined using the Rutherford backscattering spectrometry. The traditional experimental method for studying the process of interdiffusion of components in binary macroscopic systems is the placing of inert marks. However, the use of this method in systems containing thin films is hindered by the comparable thicknesses of the films and marks. This circumstance makes the mathematical modelling the most convenient method for the analysis of the interdiffusion process in thin-film systems. The interdiffusion model during the formation of polycrystalline niobium film – single-crystal silicon systems, developing the Darken’s theory for the limited solubility components was proposed. Grain boundary diffusion of silicon in the intergrain space of a polycrystalline niobium film was proposed. Numerical analysis of the experimental distribution of concentrations within the model established that silicon is the dominant diffusant in the studied system. The temperature dependence of the individual diffusion coefficient of silicon DSi = 3.0 10-12exp(-0.216 eV/(kT)) cm2/s in the temperature range 423–773 K was determined. The model is applicable to the description of the redistribution of components in the thin niobium film – single-crystal silicon system prior to synthesis conditions providing the chemical interaction of the metal with silicon and the formation of silicides. It illustrates the mechanism of the possible formation of silicide phases not by layer-by-layer growth at the Nb/Si grain boundary, but in its vicinity due to deep mutual diffusion of the components
Evaluation of the inhibitory effect of some derivatives of salts of long-chain carboxylic acids in relation to pitting corrosion of reinforcing steel in concrete
Authors: Kozaderov Oleg A. , Shevtsov Dmitry S. , Potapov Mikhail A. , Zartsyn Iliya D. , Grushevskaya Svetlana N. , Kruzhilin Alexey A. , Ilina Evgeniia A. , Tkachenko Kirill A. , Shikhaliev Khidmet S. 
Published: June 2024

Derivatives of salts of long chain carboxylic acids and dimethylaminopropylamine, including those similar in composition to vegetable oils were synthesized. The structure of the molecules of new substances was reliably confirmed using physical methods of IR-Fourier spectroscopy, NMR spectroscopy, and HPLC. The inhibitory effect of the synthesized substances on 35GS grade reinforcing steel was assessed using voltammetry. Experiments were carried out in an aqueous extract from a mortar, simulating the concrete pore solution, in the presence of chlorides as activators of pitting corrosion, as well as in samples of fine-grained concrete with periodic immersion in a chloride solution. It was found that 3-(dimethylamino)propyl-1-ammonium stearate did not exhibit an inhibitory effect. The introduction of salts of fatty acids of coconut and sunflower oils increased the anti-corrosion properties. The degree of protection was 40-44% in aqueous solutions and 30-32% for concrete samples. The time before the onset of corrosion in concrete samples was found to increase by 1.75 times compared to the control composition without additives
Natural ferromagnetic resonance in microwires and its applications. Brief review
Authors: Baranov Serghei A. 
Published: June 2024

The paper analyzes technological aspects of the Taylor–Ulitovsky method used to produce microwires of various structures. Natural ferromagnetic resonance (NFMR) in cast glass-coated amorphous magnetic micro- and nanowires was theoretically and experimentally studied. The NFMR phenomenon is due to the large residual stresses appearing in the core of the microwire during the casting process. These stresses, along with magnetostriction, determine magnetoelastic anisotropy. Besides residual stresses, the NFMR frequency is influenced by externally applied stresses on the microwire or the composite containing the so-called stress effect (SE). The dependence of the NFMR frequency on the deformation of microwires and the external stresses on them is proposed to be used for remote diagnostics in medicine
Isolation of partial coupled processes of anodic oxidation of OH– ion on gold using a combination of a graph-kinetic analysis method and linear voltammetry data
Authors: Zartsyn Ilya D. , Vvedenskii Alexander V. , Bobrinskaya Elena V. , Kozaderov Oleg A. 
Published: June 2024

The presence of several interconnected electrochemical processes occurring on the surface of an electrode, strictly speaking, does not allow the use of the principle of independent reactions. Often, partial reactions of a complex multi-stage electrochemical process are coupled both through common intermediates and through the competitive adsorption of electroactive species. The presence of conjugation leads either to a change in the potential at which the corresponding electrochemical process becomes possible or to a change in the rate of partial processes. The latter is called kinetic coupling. This does not allow the simple calculation of the rate of each partial reaction as the difference between the current density of the target and background processes. The method of kinetic diagrams can be used to establish the kinetic patterns ofsuch processes. This study shows that this method is applicable not only for the analysis of coupled electrochemical processes of various types, but can also be used in obtaining partial currents of the stages of a separate complex electrode reaction occurring in a background solution. As an example, options for the kinetic modelling of the total voltammogram of the anodic process on an Au electrode in an aqueous alkaline medium in the mode of linear potential change are considered.
The stationary degrees of covering of the gold surface with various surface-active forms of oxygen are calculated depending on the electrode potential. It was established that the change in concentration of ОН- ions mainly affects the region of their adsorption potentials. A detailed analysis of stationary partial anodic processes in the Au|OH-,H2O system was carried out and the shape of the general stationary voltammogram was determined by calculation. The latter is in qualitative agreement with the experimental polarization dependence.
It was shown that the type of calculated polarization dependence is determined by the degree of reversibility of individual stages and the rate of their occurrence. The performed analysis is necessary not only for the detailed scheme of the background anodic reaction on gold in an alkaline solution, but also for the ubsequent kinetic description of the electrooxidation process of organic substances on a gold electrode
Hubungan Asupan Energi dan Zat Gizi Makro dengan Status Gizi Anak Sekolah Dasar (SD) Muhammadiyah di Kabupaten Gresik
Authors: Sholikhah Desty Muzarofatus , Rahma Amalia 
Published: June 2024

Latar Belakang: Anak usia sekolah merupakan salah satu golongan yang rentan terhadap permasalahan gizi dan kesehatan. Faktor yang dapat mempengaruhi status gizi anak sekolah adalah asupan energi dan zat gizi makro.
Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara asupan energi dan zat gizi makro dengan status gizi pada anak Sekolah Dasar (SD) Muhammadiyah di Kabupaten Gresik.
Metode: Penelitian ini adalah observasional analitik dengan rancangan studi cross sectional. Sebanyak 231 anak dari 5 sekolah dasar Muhammadiyah di Kabupaten Gresik diambil sebagai sampel penelitian dengan cara purposive sampling. Penelitian telah dilakukan pada bulan Mei-Juni 2023. Variabel penelitian meliputi asupan energi, asupan zat gizi makro, dan status gizi. Pengumpulan data menggunakan metode wawancara dengan recall 2x24 jam, food frequency questionnaire (FFQ), serta pengukuran berat badan dan tinggi badan untuk menilai status gizi berdasarkan IMT/U. Seluruh data penelitian dianalisis menggunakan uji Spearman.
Hasil: Hasil menunjukkan terdapat hubungan antara asupan energi (p=0,000) dan protein (p=0,000) dengan status gizi, namun tidak terdapat hubungan antara asupan lemak (p=0,253) dan karbohidrat (p=0,821) dengan status gizi pada anak Sekolah Dasar (SD) Muhammadiyah di Kabupaten Gresik.
Kesimpulan: Asupan energi dan zat gizi makro terutama protein berhubungan dengan status gizi anak sekolah di Kabupaten Gresik. Membutuhkan peran serta orang tua dan guru dalam mengawasi asupan gizi pada anak sekolah agar tercapai status gizi yang baik.

Kata kunci: Asupan Energi, Zat Gizi Makro, Status Gizi, Anak Sekolah, Kabupaten Gresik
Analisis Betakaroten, Gula Total, dan Organoleptik Selai Variasi Ubi Ungu (Ipomoea batatas L. Poir) dengan Gula Singkong (Manihot esculenta)
Authors: Handayani Septy , Hidayati Khusnul 
Published: June 2024

ABSTRAK
Latar Belakang: Produktivitas ubi ungu di Indonesia cukup tinggi, salah satunya di Bondowoso yang mencapai 213,84 kuintal/ha. Ubi ungu merupakan salah satu jenis ubi jalar di Indonesia dan mengandung betakaroten sebesar 4237 µg/100 yang mampu menjaga sel dari radikal bebas dan menurunkan risiko diabetes mellitus bagi penderita prediabetes. Prevalensi prediabetes di Indonesia termasuk kategori tertinggi ketiga di dunia sebesar 27,7 juta jiwa. Prevalensi prediabetes pada tahun 2022 di Kecamatan Tapen, Bondowoso berdasarkan data Puskesmas Tapen ditemukan sebesar 12,36%.
Tujuan: Menganalisis betakaroten, gula total, dan organoleptik selai variasi ubi ungu dengan gula singkong.
Metode: Quasi experimental dengan post-test only control group design untuk mengetahui kadar betakaroten, gula total, dan organoleptik selai setelah perlakuan. Selai ubi ungu dibuat dengan mengukus ubi ungu pada suhu 95˚C selama 30 menit, lalu diblender, perbandingan air dan ubi ungu sebesar 2:1, pektin 1%, dan gula singkong lalu dipanaskan pada suhu 90˚C berturut-turut selama 3 menit dan 17 menit. Variasi perbandingan gula singkong dan ubi ungu antara lain 0%:100%; 15%:85%; 30%:70%; 45%:55%. Kadar betakaroten dianalisis dengan metode Spektrofotometri UV-Vis, gula total dengan metode Luff Schoorl, organoleptik dengan metode uji hedonik. Analisis data kadar betakaroten dan gula total mengggunakan uji One Way Anova dan uji lanjut Duncan, sedangkan analisis data uji organoleptik menggunakan uji Kruskall Wallis dan uji lanjut Dunn.
Hasil: Hasil rata-rata kadar betakaroten pada perlakuan X0, X1, X2, dan X3 berturut-turut adalah 4230,3 µg/100 gram.; 3464 µg/100 gram.; 2955,6 µg/100 gram.; dan 2257,3 µg/100 gram. Selain itu, rata-rata kadar gula total pada perlakuan X0, X1, X2, dan X3 berturut-turut adalah 2,2%; 13,7%; 27,5%; dan 39,2%. Selai yang paling disukai panelis adalah sampel X3 atau selai dengan variasi 45% gula singkong dan 55% ubi ungu.
Kesimpulan: Terdapat perbedaan yang signifikan pada kadar betakaroten, gula total, dan organoleptik selai variasi ubi ungu dengan gula singkong. Selai variasi ubi ungu dengan gula singkong dapat diterima panelis dari aspek warna, aroma, rasa, tekstur, dan keseluruhan.
NUGGET BERBASIS SUSU KERBAU DENGAN PENAMBAHAN IKAN BILIH (Mystacoleucus padangensis) SEBAGAI MAKANAN TAMBAHAN TUMBUH KEMBANG BALITA
Authors: Yahdillah Honey , Diana Fivi Melva , Helmizar Helmizar 
Published: June 2024

Ikan bilih berpotensi yang diolah menjadi salah satu produk olahan pangan dapat berfungsi sebagai penunjang dalam penanganan penurunan stunting pada balita. Penelitian ini bertujuan untuk mengembangkan produk Nugget susu kerbau dengan penambahan ikan bilih (Mystacoleucus padangensis) terhadap uji organoleptik dan kandungan zat gizi sebagai makanan tambahan untuk mendukung tumbuh kembang balita (usia 1-3 tahun). Metode penelitian ini dilakukan secara true experiment yang dilakukan di laboratorium berupa percobaan penambahan ikan bilih dalam pembuatan produk Nugget susu kerbau. Produk dibuat dengan 4 perlakuan yang terdiri dari F0 (formula standar), F1, F2, dan F3 dengan penambahan tepung ikan bilih berturut-turut sebesar 0%, 5%, 15%, dan 25%. Percobaan dilakukan dengan dua kali ulangan menggunakan Rancangan Acak Lengkap (RAL). Uji organoleptik dilakukan menggunakan lembar pengujian berdasarkan SNI 01-2346- 2006 tentang petunjuk pengujian organoleptik atau sensori yang dimodifikasi sesuai kebutuhan penelitian dan melibatkan 25 orang panelis agak terlatih. Analisis data dilakukan menggunakan uji Kruskal Wallis dengan taraf pengujian 5% dan dilanjutkan dengan uji Mann Whitney sebagai uji lanjut. Hasil penelitian menyatakan bahwa berdasarkan uji organoleptik, formula yang paling disukai oleh panelis adalah F1 dengan karakteristik mutu warna kuning cerah, gurih, harum, dan tekstur empuk. Tidak ada perbedaan nyata antara keempat formula (p-value >0,05). Berdasarkan uji kandungan zat gizi, F1 juga menjadi formula terbaik dengan kandungan gizi berupa kadar air 46,90%, kadar abu 2,32%, protein 11,77%, lemak 7,60%, kalsium 5,52 mg/100 gr dan zink 16,63 mg/100 gr. Kesimpulan dari penelitian ini adalah pada ketiga perlakuan, formula terpilih adalah F1 dengan penambahan ikan bilih sebanyak 5%.
Nineteen-Year-Old Woman with Symptomatic Intramuscular Thigh Hemangioma—Radiographic Changes and Management
Authors: Puleo James M. , Acosta Ernesto M. , Crowley Stephen G. , DiCaprio Matthew R. 
Published: June 2024

Case:
We report a case of an intramuscular thigh hemangioma in a 19-year-old woman with a several year history of atraumatic thigh pain. Radiographs obtained by her primary care physician demonstrated periosteal bone reaction, prompting referral to Orthopaedic Oncology department. The patient had successful symptomatic management with propranolol.

Conclusion:
The case highlights the diagnosis and potential treatments. In a stepwise approach to care for symptomatic benign vascular lesions, propranolol has been a proven therapeutic option and may be a useful first-line therapy for symptomatic hemangiomas.
Educational attainment polygenic risk score and symptom severity change after Internet-delivered cognitive behaviour therapy for depression and anxiety
Authors: Bäckman Julia , Wallert John , Halvorsen Matthew , Crowley James , Mataix-Cols David , Rück Christian 
Published: June 2024

Abstract

Depressive and anxiety disorders are among the leading causes of disability worldwide. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom change from clinical variables alone is challenging. Genetic data could potentially add predictive power and help us understand who will benefit most from ICBT. We conducted a study including 2668 adults (62% women, mean age 35.6 years) from the Swedish MULTI-PSYCH cohort to investigate the association between polygenic risk scores (PRS) from eight psychiatric and cognitive phenotypes and symptom change after ICBT. All participants had been diagnosed with depression, panic disorder or social anxiety disorder and treated with ICBT. The primary clinical outcome was a harmonised score across three different diagnosis-specific symptom rating instruments and measured weekly throughout ICBT. PRS were computed for attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder and schizophrenia, cross-disorder psychopathology, educational attainment, and intelligence, using large discovery data sets. Linear mixed-effects models identified a significant association between the PRS for educational attainment (PRS-EDU) and symptom change (B = -0.73, p = .03), suggesting that a higher PRS-EDU was associated with lower symptom severity. This remained significant after additional covariate adjustment. No other PRS were significant. In the adjusted model, there was a significant PRS-EDU*time interaction, indicating that PRS-EDU also influenced the symptom change rate during treatment. When excluding outliers, the interaction effect was significant in both the crude and adjusted model. While these results await replication, they could have important implications for how the ICBT could be adapted to suit a wider portion of the population.
Gut Microbiome in Tendinopathy: Mendelian Randomization and Bioinformatics Therapeutic Targets Study
Authors: Abdou Ihab Elsayed Mohamed Ali , Thein-Win Min , Ming Hao 
Published: June 2024

Abstract

Objective: To explore the relationship between the gut microbiome (GM) and tendinopathy, examining possible shared pathogenic pathways and relevant genes of significant importance.
Design:This study employed a two-sample bidirectional and multivariable Mendelian Randomization (MR) approach, supplemented by bioinformatics analysis.
Patients: The MR analysis utilized summary statistics from the genome-wide association studies of gut microbial taxa (Dutch Microbiome Project, n=7738). Data on five different tendinopathy phenotypes were sourced from the FinnGen database, encompassing Achilles tendinitis (AT, n_cases=3113), bicipital tendinitis (BT, n_cases=1317), tendinitis of the shoulder (ST, n_cases=1646), gluteal tendinitis (GT, n_cases=854), and patellar tendinitis (PT, n_cases=439). Genetic data for tendinopathy used in the bioinformatics analysis were derived from 23 patients.
Intervention (s): None.
Mains Outcome Measure: Incidences of Achilles tendinitis (AT), tendinitis of the shoulder (ST), bicipital tendinitis (BT), gluteal tendinitis (GT), and patellar tendinitis (PT).
Result(s): We identified 33 causal relationships between specific gut microbiota (GM) and various forms of tendinitis. Key findings include eight GMs causally related to AT and nine to BT. Five GMs showed significant associations with GT, and another nine with PT. Three specific GMs were significantly associated with ST. Bioinformatics analysis of tendinopathy samples revealed 682 differentially expressed genes (DEGs). We identified 711 genes associated with 28 gut microbiotas after excluding five due to pleiotropy, reverse causality, and unspecified reasons. The analysis identified 682 DEGs and 711 GMs-associated genes, with an overlap of 28 common gene sets (CGS). Enrichment analysis of the 13 CGS identified four major gene pathways. Using a Protein-Protein Interaction (PPI) network, we targeted the key gene FN1.
Conclusion (s): Our findings suggest a genetic correlation between 33 GMs and various tendinopathies, potentially mediated by the overexpression of the FN1 gene and the regulation of four gene pathways.
Comprehensive analysis of the metabolomics and transcriptomics uncovers the dysregulated network and potential biomarkers of Triple Negative Breast Cancer
Authors: Gong Sisi , Liao Zhijun , Wang Meie , Lian Fen , Tong Ruirui , Huang Rongfu , Fan Chun mei 
Published: June 2024

Abstract

Triple-negative breast cancer (TNBC) is recognized for its aggressive nature, lack of effective diagnosis and treatment, and generally poor prognosis. The objective of this study was to investigate the metabolic changes in TNBC using metabolomics approaches and to explore underlying mechanisms through integrated analysis with transcriptomics. In this study, serum untargeted metabolic profiles were firstly explored between 18 TNBC and 21 healthy controls (HC) by liquid chromatography-mass spectrometry (LC-MS), identifying a total of 22 significantly altered metabolites (DMs). Subsequently, the receiver operating characteristic analysis revealed that 7-methylguanine could serve as a potential biomarker for TNBC in both the discovery and validation sets. Additionally, transcriptomic datasets were retrieved from the GEO database to identify differentially expressed genes (DEGs) between TNBC and normal tissues. An integrative analysis of the DMs and DEGs was subsequently conducted, uncovering potential molecular mechanisms underlying TNBC. Notably, three pathways—tyrosine metabolism, phenylalanine metabolism, and glycolysis/gluconeogenesis—were enriched, explaining the energy metabolism disorders in TNBC. Within these pathways, two DMs (4-hydroxyphenylacetaldehyde and oxaloacetic acid) and six DEGs (MAOA, ADH1B, ADH1C, AOC3, TAT, and PCK1) were identified as critical components. In summary, this study highlights metabolic biomarkers that could potentially be utilized for the diagnosis and screening of TNBC. The comprehensive analysis of metabolomics and transcriptomics data provides a validated and in-depth understanding of TNBC metabolism.
Simultaneous therapeutic and diagnostic applications of magnetic PLGA nanoparticles loaded with doxorubicin in rabbit
Authors: Salmasi Zahra , Kamali Hossein , Rezaee Hanieh , Nazeran Faezeh , Jafari Zahra , Eisvand Farhad , Teymouri Manoocher , Khordad Elnaz , Mosafer Jafar 
Published: June 2024

Abstract

In this study, DOX[1] and Fe3O4 magnetic nanocrystals (SPIONs[2]) were encapsulated in the PLGA-PEG[3] nanoparticles for theranostic purposes. The final prepared formulation which is called NPs[4] exhibited a particle size with a mean diameter of ~209 nm and a sufficient saturation magnetization value of 1.65 emu/g. The NPs showed faster DOX release at pH 5.5 compared to pH 7.4. Also, the cytotoxicity effect of NPs increased compared to Free-DOX alone in C6 glioma cancer cells. For in vivo investigations, the 2.2 Kg rabbits were injected with NPs formulations via a central articular anterior vein in their ears. Furthermore, the images of rabbit organs were depicted via MR[5] and fluorescent imaging techniques. A negative contrast (dark signal) was observed in T2[6] weighted MR images of IV[7]-injected rabbits with NPs compared to the control ones. The organ’s florescent images of NPs-injected rabbits showed a high density of red color related to the accumulation of DOX in liver and kidney organs. These data showed that the NPs have no cytotoxicity effect on the heart. Also, the results of histopathological tests of different organs showed that the groups receiving NPs and Free-DOX were almost similar and no significant difference was seen, except for the cardiac tissue in which the pathological effects of NPs were significantly less than the Free-DOX. Additionally, pharmacokinetic studies were also conducted at the sera and whole bloods of IV-injected rabbits with NPs and Free-DOX. The pharmacokinetic parameters showed that NPs could enhance the DOX retention in the serum compared to the Free-DOX. Altogether, we aimed to produce a powerful delivery nanosystem for its potential in dual therapeutic and diagnostic applications which are called theranostic agents.