bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective clinical trial evaluating the safety and efficacy of the combination of rituximab and plerixafor as a mobilization regimen for patients with lymphoma
Authors: Kaufman Jonathan L. , Flowers Christopher R. , Rados Karen D. , Calandra Gary B. , Vose Julie M. , Hewes L. Becker , Lonial Sagar , Langston Amelia A. , Khoury H. Jean , Lechowicz Mary Jo , Waller Edmund K. 
Published: May 2012

BACKGROUND: Previous reports suggested that rituximab may impair stem cell collection and posttransplant engraftment in lymphoma patients undergoing autologous hematopoietic progenitor cell transplantation.STUDY DESIGN AND METHODS: A prospective biologic allocation study examined the effect of adding rituximab to a mobilization regimen of plerixafor and granulocyte–colony‐stimulating factor (G‐CSF) for patients with CD20+ lymphoma compared with CD20− lymphoma patients mobilized without rituximab. The primary endpoint was safety of the rituximab‐containing regimen; secondary endpoints compared the efficiency of stem cell collection, posttransplant engraftment, graft characteristics, mobilization kinetics, immune reconstitution, and engraftment durability between the cohorts of patients with CD20+ and CD20− lymphoma.RESULTS: Fifteen subjects assigned to each treatment arm were accrued. Both mobilization regimens had similar toxicities. The median number of CD34+ cells collected (7.4 × 106/kg vs. 6.4 × 106/kg) and the median numbers of days of apheresis needed to collect stem cells were not different between the CD20+ and CD20− cohorts. No significant differences in neutrophil engraftment (median, 13.5 days vs. 13 days) or platelet engraftment (22 vs. 21 days) or in graft durability were seen comparing patients with CD20+ versus CD20− lymphoma. There were no significant differences in the kinetics of blood T‐cell or natural killer–cell reconstitution comparing the two groups. B‐cell reconstitution was delayed in the CD20+ lymphoma group, but this did not translate into a significant increase in infectious complications.CONCLUSION: Rituximab can be safely added to the combination of plerixafor and G‐CSF as a mobilization strategy without excess toxicity or posttransplant engraftment delays for patients with chemosensitive lymphoma undergoing autologous hematopoietic progenitor cell transplantation.
Risk Factors for Drug‐resistant Streptococcus pneumoniae and Antibiotic Prescribing Practices in Outpatient Community‐acquired Pneumonia
Authors: Jenkins Timothy C. , Sakai Joy , Knepper Bryan C. , Swartwood Claire J. , Haukoos Jason S. , Long Jeremy A. , Price Connie S. , Burman William J. 
Published: May 2012

ACADEMIC EMERGENCY MEDICINE 2012; 19:703–706 © 2012 by the Society for Academic Emergency MedicineAbstractObjectives:  Due to antimicrobial resistance in Streptococcus pneumoniae, national guidelines recommend a respiratory fluoroquinolone or combination antimicrobial therapy for outpatient treatment of community‐acquired pneumonia (CAP) associated with risk factors for drug‐resistant S. pneumoniae (DRSP). The objectives of this study were to assess the prevalence of these risk factors and antibiotic prescribing practices in cases of outpatient CAP treated in the acute care setting.Methods:  This was a retrospective cohort study of adult outpatients treated for CAP in the emergency department (ED) or urgent care center of an urban, academic medical center from May 1, 2009, through October 31, 2009, and comparison of antibiotic therapy in cases with and without DRSP risk factors.Results:  Of 175 patients, 90 (51%) had at least one DRSP risk factor, most commonly asthma (n = 28, 16%), alcohol abuse (n = 24, 14%), diabetes mellitus (n = 18, 10%), chronic obstructive pulmonary disease (n = 16, 9%), age > 65 years (n = 16, 9%), and use of antibiotics within 3 months (15, 9%). Antibiotic prescriptions were similar among cases with and without DRSP risk factors: a macrolide (62% vs. 59%, respectively, p = 0.65), doxycycline (27% vs. 28%, p = 0.82), or a respiratory fluoroquinolone (9% vs. 9%, p = 0.90). Concordance with national guideline treatment recommendations was significantly lower in cases with DRSP risk factors (9% vs. 87%, p < 0.0001).Conclusions:  DRSP risk factors were present in approximately half of outpatient CAP cases treated in the acute care setting; however, guideline‐concordant antibiotic therapy was infrequent. Strict adherence to current guidelines would substantially increase use of fluoroquinolones or combination therapy. Whether the potential risks associated with these broad‐spectrum regimens are justified by improved clinical outcomes requires further study.
Emergency Department Patients With Diabetes Have Better Glycemic Control When They Have Identifiable Primary Care Providers
Authors: Horwitz David A. , Schwarz Evan S. , Scott Mitchell G. , Lewis Lawrence M. 
Published: May 2012

ACADEMIC EMERGENCY MEDICINE 2012; 19:00–00 © 2012 by the Society for Academic Emergency MedicineAbstractObjectives:  The objective was to determine if emergency department (ED) patients with diabetes mellitus (DM) who have primary care providers (PCPs) have better control of their DM than patients with no PCPs.Methods:  This was a prospective, cross‐sectional, observation study at a large, adult, urban, academic ED with 85,000 annual visits. ED patients with a history of DM were eligible. Patients with severe systemic disease, diabetic ketoacidosis (DKA), sepsis, active steroid use, pregnancy, or cognitive impairment were excluded. Consenting patients had hemoglobin A1c (HgbA1c) analysis and completed a questionnaire regarding demographics, lifestyle, medication usage, educational level attained, and health care access, including whether or not they had PCPs. HgbA1c levels were compared between subjects with and without PCPs using medians with interquartile ranges (IQRs). A continuous plot was developed to demonstrate the proportion of patients without PCPs (PCP−) compared to those with PCPs (PCP+) at every level of %HgbA1c across the entire measured range. Multivariate logistic regression analysis was used to determine which clinical and demographic factors obtained from the questionnaire were associated with improved glycemic control (increased relative risk [RR] of having a %HgbA1c < 8%).Results:  A total of 284 patients were screened; 227 were enrolled, had HgbA1c analysis performed, and had complete PCP, race, and sex information. Complete demographic data (insurance status, employment status, etc.) were available on 209 subjects. Sixty‐four of the 227 patients (28.2%) denied having PCPs. Median HgbA1c was 7.7% (IQR = 6.5% to 9.68%) in PCP+ versus 8.9% (IQR = 6.8% to 11.3%) in PCP− patients (p = 0.01). Ninety‐one of 163 (55.8%) PCP+ subjects had a median HgbA1c < 8% versus 25 of 64 (39.1%) in the PCP− group (p = 0.02). After adjusting for multiple clinical and demographic variables, having a PCP remained significantly associated with a median HgbA1c value less than 8% (RR = 1.43; p = 0.04).Conclusions:  Diabetes control was significantly better in patients with PCPs, even after adjusting for a number of potentially confounding social and demographic factors.
PTH [1‐34] enhances bone response around titanium implants in a rabbit model of osteoporosis
Authors: Almagro M. Isabel , Roman‐Blas Jorge A. , Bellido Miriam , Castañeda Santos , Cortez Raul , Herrero‐Beaumont Gabriel 
Published: May 2012

AbstractIntroductionDental implant osseointegration can be impaired in medical conditions with low bone mass, such as glucocorticoid‐induced osteoporosis. Intermittent human parathyroid hormone (PTH) [1‐34] administration has shown relevant anabolic bone activity in various animal models of osteoporosis. Therefore, we studied the effects of intermittent PTH [1‐34] on bone response around titanium implants in experimental osteoporosis induced by ovariectomy and glucocorticoid administration.MethodsTitanium dental implants were placed in the proximal tibia metaphysis in 38 animals. Twenty‐eight rabbits had undergone bilateral ovariectomy and further methylprednisolone administration for 4 weeks to induce osteoporosis. Ten healthy rabbits were used as controls. At week 8, osteoporotic rabbits started saline vehicle or intermittent PTH administration for 12 weeks. Bone mineral density (BMD) was assessed in peri‐implant area, lumbar spine, and global and subchondral knee bone at baseline, and weeks 6 and 20. Animal sacrifice was carried out at week 21. Afterward, tibiae were removed for μCT morphometry and undecalcified sections were evaluated by light and scanning electron microscopy.ResultsPTH increased bone‐to‐implant contact compared with control rabbits or vehicle administration in osteoporotic rabbits (P < 0.005). PTH‐induced new bone formation around external and internal surfaces of titanium implants led to a significant increase of BMD at peri‐implant area in osteoporotic rabbits at week 20, when compared with vehicle (P < 0.005). Likewise, PTH increased BMD in other analysed regions.ConclusionsIntermittent administration of PTH [1‐34] enhances the bone response around titanium implants in a rabbit model of ovariectomy and glucocorticoid‐induced osteoporosis.
Patch testing with the textile dyes Disperse Orange 1 and Disperse Yellow 3 and some of their potential metabolites, and simultaneous reactions to para‐amino compounds
Authors: Malinauskiene Laura , Zimerson Erik , Bruze Magnus , Ryberg Kristina , Isaksson Marlene 
Published: May 2012

Background. It is known that, in vitro, human skin bacteria are able to split disperse azo dyes into the corresponding aromatic amines, some of which are sensitizers in the local lymph node assay. We hypothesize that the molecules of disperse dyes migrate onto the skin while garments are worn, and are metabolized and degraded by commensal skin bacteria. These molecules penetrate the skin and induce sensitization.Objectives. To evaluate the elicitation capacities of the possible azo‐degradation products of the selected azo disperse dyes in patients allergic to them and to compare it with the elicitation capacities of other para‐compunds.Methods. Ten patients allergic to Disperse Yellow 3 (DY3) and/or Disperse Orange 1 (DO1) were patch tested with a dilution series of the purified dyes 4‐nitroaniline and p‐aminodiphenylamine in concentrations equimolar to those of purified DO1 in the dilution series, as well as 4‐aminoacetanilide and 2‐amino‐p‐cresol in concentrations equimolar to those of purified DY3 in the dilution series.Results. Three patterns of patch test reactions could be seen. The 6 patients who were positive to DO1 and DY3 also reacted to p‐aminodiphenylamine and 2‐amino‐p‐cresol. Two patients were positive to DO1 only, and both reacted to p‐aminodiphenylamine, but to neither 4‐aminoacetanilide or 2‐amino‐p‐cresol. Two patients did not react to DO1 or DY3 on this occasion.Conclusion. We show that it is possible that the major sensitizers in contact allergy to DO1 and DY3 are their metabolites, p‐aminodiphenylamine and 2‐amino‐p‐cresol, respectively, which might be formed by the azoreductase pathway of skin bacteria.
Emerging Themes in Uterine Natural Killer Cell Heterogeneity and Function
Authors: Hatta Kota , MacLeod R. John , Gerber Scott A. , Croy B. Anne 
Published: May 2012

ProblemUnderstanding of uterine natural killer (uNK) cell functions during normal pregnancy remains incomplete.Method of studyCloud tag analysis of literature was used to document themes addressed experimentally for uNK cells. Immunohistochemistry, including whole‐mount staining of early implantation sites, separation of uNK cells into molecularly distinct subsets, and physiologic measurements in normal and mutant mice, are further advancing understanding of uNK cell biology.ResultsLiterature analyses revealed three key, current uNK cell research themes: angiogenesis, spiral arterial remodeling/pre‐eclampsia/hypertension and infertility. UNK cells are being defined as cells potentially regulated by Wnt signaling that are heterogeneous in progenitor source and function and make unique contributions to implantation site development prior to spiral arterial remodeling.ConclusionFuture studies are poised to define uNK cell progenitor cells, identify the signaling pathways supporting established uNK cell functions and move current understanding of mouse uNK cells to clinical research questions.
‘Rati Viparite’: Gitagovinda and Erotic (Trans)migrations in Nineteenth Century Bengal I
Authors: Sengupta Rangeet 
Published: May 2012

AbstractThe paper deals with some of the translations and adaptations of Gitagovinda, a 12th century Sanskrit text, in the late 18th and 19th century Bengal. These translations and derivative adaptations were shaped by the colonial experience in Bengal and reveal important strands of colonial discourse and exchange. The English translation of the text by William Jones (in 1789), the famed philologist and the founder of the Asiatic Society of Bengal, served as one of the seminal texts of Orientalist exploration in South Asia. Also discussed in the paper are Rasamaya Dasa’s Bengali translation of Gitagovinda (published in 1817) and the several adaptations of the text published by the Battala printers. The ambivalence about eroticism in the text has been discussed, along with the subsequent histories of the text as a cultural commodity in colonial Bengal.
Covered removable self‐expandable metal stents for the treatment of refractory benign biliary disease
Authors: MANGIAVILLANO Benedetto , LUIGIANO Carmelo , VIAGGI Paolo , FABBRI Carlo , D'IMPERIO Nicola , SANTORO Tara , MASCI Enzo 
Published: May 2012

OBJECTIVE:  The aim of the study was to verify the use of covered removable self‐expandable metal stents (CRSEMS) in benign biliary disease after a failure of traditional endoscopic treatment.METHODS:  A total of 23 patients who failed traditional endoscopic therapy were enrolled in the study and treated with CRSEMS.RESULTS:  Among all the patients, 11 had a bile leak and 12 suffered benign biliary stenosis. Technical success and immediate clinical success were achieved in all the patients. The overall long‐term clinical success rate after stent removal was 100%. The CRSEMS were left in place for a median of 47 days (range 30–240 days). Immediate complications occurred in one patient, stent migration in two and overgrowth of inflammatory tissue in the stent in two.CONCLUSION:  CRSEMS is an excellent treatment option for patients with benign biliary disease.
Magnetic resonance imaging (MRI) of articular cartilage of the knee using ultrashort echo time (uTE) sequences with spiral acquisition
Authors: Goto Hajimu , Fujii Masahiko , Iwama Yuki , Aoyama Nobukazu , Ohno Yoshiharu , Sugimura Kazuro 
Published: May 2012

SummaryThe objective of this study was to evaluate the sensitivity of ultrashort echo time (uTE) sequence for visualisation of calcified deep layers of articular cartilage. MRI with a uTE sequence was performed on five healthy volunteers. Signals from the calcified deep layers of the articular knee cartilage were evaluated on uTE subtraction images and computed tomography images. The calcified deep layers of the articular cartilage changed from having a low to a high signal when imaged with a uTE sequence. The reported uTE sequence was effective in imaging the deep layers of the knee cartilage.
Real Polymer‐Free Sirolimus‐ and Probucol‐Eluting Versus Biodegradable Polymer Sirolimus‐Eluting Stents for Obstructive Coronary Artery Disease: DKPLUS‐Wave 1, a Multicenter, Randomized, Prospective Trial
Authors: Chen Shao‐Liang , Ye Fei , Zhang Jun‐Jie , Zou Jian‐Jun , Qian Xue‐Song , Li Feng , Yang Song , Ge Zhen , Shan Shou‐Jie , Li Xiao‐Bo , Xu Tian , Kan Jing , Lin Ling , Han Ya‐Ling 
Published: May 2012

SummaryBackgroundPolymer‐free sirolimus‐ and probucol‐eluting stents (Real Dual drug‐eluting stents [DES]) is as effective as first‐generation DES in treating coronary artery stenosis. It is unknown whether sirolimus‐eluting stents containing biodegradable polymer (Excel) would be superior to real Dual DES. This study aimed to investigate the difference in target vessel revascularization (TVR) at 12 months in patients with coronary artery disease treated by the implantation of Dual DES or Excel stents.MethodsThree hundred and forty‐six patients with de novo coronary artery disease were recruited from six centers in China and randomly assigned to either the Dual DES or the Excel group. The primary endpoint was the occurrence of TVR at 12 months. The secondary endpoint was angiographic in‐stent restenosis and late lumen loss at 13 months. Stent thrombosis (ST) served as the safety endpoint. Dual anti‐platelet therapy (DAPT) was prescribed for 6 months.ResultsClinical follow‐up for 12 months and repeat angiography at 13 months were available in 100% and >90% of patients, respectively. The ISR and in‐stent late loss were significantly different between the Excel (3.1%, 0.09 ± 0.11 mm) and the Dual DES (19.5%, 0.36 ± 0.32 mm, P < 0.001, P < 0.001, respectively) groups. The TVR (3.5%) in the Excel group was significantly less than in the Dual DES group (13.9%, P = 0.001). The ST rate beyond 12 months in the Dual DES group was 0%, and this was 1.2% in the Excel group (P = 0.499).ConclusionsThe Excel stent was statistically superior to the Dual DES in terms of restenosis, late loss, and TVR for long lesions.
Validation of micro‐CT against the section method regarding the assessment of marginal leakage of sealants
Authors: Chen X , Cuijpers VMJI , Fan MW , Frencken JE 
Published: May 2012

AbstractBackground:  The aim of this study was to validate the micro‐CT and related software against the section method using the stereomicroscope for marginal leakage assessment along the sealant‐enamel interface.Methods:  Pits and fissures of the occlusal surface of 10 teeth were sealed with a resin‐fissure sealant material without acid etching, thermocycled for 5000 cycles, immersed in 50% silver nitrate for three hours and scanned using micro‐CT. Teeth were embedded in epoxy resin and cut in three sections. The middle section was subjected to micro‐CT and stereomicroscopy. Images were taken from the left and right sides of the sealant‐enamel interface at both the left and the right site of the section. Two experienced evaluators assessed marginal leakage.Results:  Both assessment instruments observed no leakage in 37 out of the 40 images evaluated. Leakage at the sealant‐enamel interface was observed in three stereomicroscopy images only. A fracture line in the sealant was seen on eight stereomicroscopy images and observed in only two micro‐CT images.Conclusions:  The quality of the micro‐CT and related software used in the present study does not qualify it to replace the section method as the gold standard for marginal leakage assessment at the sealant‐enamel interface of permanent teeth.
Laparoscopic cauterisation of the testicular arteries to manage haemoperitoneum in a gelding
Authors: Holmes J. M. , Nath L. C. , Muurlink M. A. 
Published: May 2012

SummaryA Thoroughbred gelding had chronic episodic intra‐abdominal haemorrhage following standing castration, presumed to originate from a testicular artery. No coagulopathy could be detected and resolution of haemorrhage was achieved by laparoscopic electrocoagulation of both testicular arteries 6 weeks after castration. Blood drained from the abdomen during surgery was filtered then auto‐transfused. Post operative complications included pigmenturia, incisional pain and large colon impaction.
Community pharmacists' perceptions of the skin conditions they encounter and how they view their role in dermatological care
Authors: Tucker Rod 
Published: May 2012

Abstract

Objectives
To explore pharmacists' perceptions of the skin conditions they encounter, sources of postgraduate dermatological training and views of their role in the management of patients with skin problems.

Method
A self-completion questionnaire was sent to a random sample of 3500 community pharmacists in England and Wales.

Key findings
Seventy-eight per cent of pharmacists felt that patients sought their advice on problems about dry skin on a weekly basis. A total of 64.8% had undertaken postgraduate training in dermatology and the majority agreed that they played an important role in managing patients with skin problems.

Conclusion
Pharmacists routinely encounter a small number of skin conditions and believe they can contribute towards the care of patients with skin diseases.
Genome Sequences of Two Plant Growth-Promoting Fluorescent Pseudomonas Strains, R62 and R81
Authors: Mathimaran N. , Srivastava R. , Wiemken A. , Sharma A. K. , Boller T. 
Published: May 2012

ABSTRACT
Plant growth-promoting rhizobacterial (PGPR) strains R62 and R81 have previously been isolated and characterized as part of the Indo-Swiss Collaboration in Biotechnology. Here we present the draft genome sequences of these two PGPR strains, with the aim of unraveling the mechanisms behind their ability to promote wheat growth.
Genome Sequences of Five Salmonella enterica Serovar Heidelberg Isolates Associated with a 2011 Multistate Outbreak in the United States
Authors: Hoffmann Maria , Zhao Shaohua , Luo Yan , Li Cong , Folster Jason P. , Whichard Jean , Allard Marc W. , Brown Eric W. , McDermott Patrick F. 
Published: May 2012

ABSTRACT

Salmonella enterica
serovar Heidelberg has caused numerous outbreaks in humans. Here, we report draft genomes of five isolates of serovar Heidelberg associated with the recent (2011) multistate outbreak linked to ground turkey in the United States. Isolates 2011K-1110 and 2011K-1132 were recovered from humans, while isolates 2011K-1138, 2011K-1224, and 2011K-1225 were recovered from ground turkey. Whole-genome sequence analysis of these isolates provides a tool for studying the short-term evolution of these epidemic clones.
Genome Sequence of Diplorickettsia massiliensis, an Emerging Ixodes ricinus-Associated Human Pathogen
Authors: Mathew Mano J. , Subramanian Geetha , Nguyen Thi-Tien , Robert Catherine , Mediannikov Oleg , Fournier Pierre-Edouard , Raoult Didier 
Published: May 2012

ABSTRACT

Diplorickettsia massiliensis
is a gammaproteobacterium in the order
Legionellales
and an agent of tick-borne infection. We sequenced the genome from strain 20B, isolated from an
Ixodes ricinus
tick. The genome consists of a 1,727,973-bp chromosome but no plasmid and includes 2,269 protein-coding genes and 42 RNA genes, including 3 rRNA genes.
Draft Genome Sequence for Microbacterium laevaniformans Strain OR221, a Bacterium Tolerant to Metals, Nitrate, and Low pH
Authors: Brown Steven D. , Palumbo Anthony V. , Panikov Nicolai , Ariyawansa Thilini , Klingeman Dawn M. , Johnson Courtney M. , Land Miriam L. , Utturkar Sagar M. , Epstein Slava S. 
Published: May 2012

ABSTRACT

Microbacterium laevaniformans
strain OR221 was isolated from subsurface sediments obtained from the Field Research Center (FRC) in Oak Ridge, TN. It was characterized as a bacterium tolerant to heavy metals, such as uranium, nickel, cobalt, and cadmium, as well as nitrate and low pH. We present its draft genome sequence.
Complete Genome Sequence of Mycobacterium phlei Type Strain RIVM601174
Authors: Abdallah Abdallah M. , Rashid Mamoon , Adroub Sabir A. , Arnoux Marc , Ali Shahjahan , van Soolingen Dick , Bitter Wilbert , Pain Arnab 
Published: May 2012

ABSTRACT

Mycobacterium phlei
is a rapidly growing nontuberculous
Mycobacterium
species that is typically nonpathogenic, with few reported cases of human disease. Here we report the whole genome sequence of
M. phlei
type strain RIVM601174.
Draft Genome Sequence of Rubrivivax gelatinosus CBS
Authors: Hu Pingsha , Lang Juan , Wawrousek Karen , Yu Jianping , Maness Pin-Ching , Chen Jin 
Published: May 2012

ABSTRACT

Rubrivivax gelatinosus
CBS, a purple nonsulfur photosynthetic bacterium, can grow photosynthetically using CO and N
2
as the sole carbon and nitrogen nutrients, respectively.
R. gelatinosus
CBS is of particular interest due to its ability to metabolize CO and yield H
2
. We present the 5-Mb draft genome sequence of
R. gelatinosus
CBS with the goal of providing genetic insight into the metabolic properties of this bacterium.