bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Affecting Management of Acute Ischaemic Stroke with Reference to Intravenous Thrombolysis and Its Impact on Short-term Outcome
Authors: Ramnani Juhi , Gadani Zalak 
Published: May 2024

Background: Stroke is a major global health concern, ranking second in terms of fatality worldwide, following ischaemic heart disease. However, few stroke patients arrive at the hospital within the optimal time for thrombolysis, and even among those who do, not all receive this therapy. Therefore, the objective of the study was to examine the factors that influence the treatment of acute ischaemic stroke (AIS), particularly with intravenous thrombolysis and to evaluate the short-term outcomes. Methods: This prospective observational study was carried out between August 2019 and August 2021 in the emergency department of a tertiary care hospital. Patients with AIS who were eligible for intravenous thrombolysis within 4.5 hours of the beginning of symptoms were included in the study. Comprehensive assessments, including history, examinations and blood investigations, were conducted. Thrombolytic treatment was administered within the specified time frame, while antiplatelets were given in other cases. Follow-up evaluations were conducted at discharge and 90 days. Results: The age distribution, comorbidities and CT-MRI findings were similar between individuals who received thrombolysis and those who did not. Among the thrombolysis group, 84% had no complications, while 8% experienced intracerebral haemorrhage and 8% had an extension of the infarction. The overall mortality rate was 13.33% for non-thrombolysis patients and 12% for thrombolysis recipients, with no statistically significant difference between the two groups. Conclusion: The results highlight the need for careful consideration when deciding to use thrombolysis for AIS cases. Additionally, they emphasise the importance of actively monitoring and effectively managing any potential treatment complications.
Influence of Isolated Talonavicular and Subtalar Joint Arthrodesis on Hindfoot Kinematics and Range of Motion During Cadaveric Gait Simulation
Authors: Palma Joaquin , Kim Jaeyoung , Hoffman Jeffrey W. , Ellis Scott J. , Deland Jonathan T. , Demetracopoulos Constantine A. , Steineman Brett D. 
Published: May 2024

Background: Isolated subtalar and talonavicular joint arthrodeses have been associated with adjacent joint arthritis and altered hindfoot kinematics during simplified loading scenarios. However, the effect on kinematics during dynamic activity is unknown. This study assessed changes in subtalar and talonavicular kinematics after isolated talonavicular (TNiso) and subtalar (STiso) arthrodesis, respectively, during stance simulations. Methods: Fourteen midtibia specimens received either a TNiso or STiso arthrodesis, with 7 randomized to each group. A 6-degree-of-freedom robot sequentially simulated the stance phase for the intact and arthrodesis conditions. Bootstrapped bias-corrected 95% CIs of the talonavicular and subtalar joint kinematics were calculated and compared between conditions. Results: The TNiso decreased subtalar inversion, adduction, and plantarflexion in late stance ( P < .05). The subtalar range of motion in the sagittal and coronal planes decreased by 40% ( P = .009) and 46% ( P = .002), respectively. No significant changes in talonavicular joint kinematics were observed after isolated subtalar arthrodesis; however, the range of motion was reduced by 61% ( P = .007) and 50% ( P = .003) in the coronal and axial planes, respectively. Conclusion: In this model for arthrodesis, changes in subtalar kinematics and motion restriction were observed after isolated talonavicular arthrodesis, and motion restriction was observed after isolated subtalar arthrodesis. Surprisingly, talonavicular kinematics did not appear to change after isolated subtalar arthrodesis. Clinical Relevance: Both joint fusions substantially decrease the motion of the reciprocal adjacent joint. Surgeons should be aware that the collateral costs with talonavicular fusion appear higher, and it has a significant effect on subtalar kinematics during the toe-off phase of gait.
Natural History and Prognostic Model of Untreated Papillary Thyroid Cancer: A SEER Database Analysis
Authors: Wang Dasong , Yang Yan , He Yu , Yang Hongwei , Yang Lei 
Published: May 2024

Purpose This investigation leveraged the SEER database to delve into the progression patterns of PTC when left untreated. Furthermore, it aimed to devise and authenticate a nomogram for prognosis prediction for such patients. Methods We extracted data from the SEER database, focusing on PTC-diagnosed individuals from 2004-2020. To discern disease progression intervals, median survival times across stages were gauged, and the disease progression time was estimated by subtracting the median survival time of a more severe stage from its preceding stage. Prognostic determinants in the training set were pinpointed using both univariate and multivariate Cox regression. Using these determinants, a prognostic nomogram was crafted. Results In untreated PTC patients, those in stages I and II had a favorable prognosis, with 10-year overall survival rates of 86.34% and 66.03%, respectively. Patients in stages III and IV had a relatively poorer prognosis. The median survival time of stage III, stage IVA, stage IVB and stage IVC patients was 108months, 43 months, 20 months and 8 months, respectively. The deduced progression intervals from stages III-IVC were 65, 23, and 12 months. In the training set, age, tumor stage, gender, and marital status were identified as independent risk factors influencing the prognosis of untreated PTC, and a nomogram was constructed using these variables. Conclusion In the absence of treatment intervention, early-stage PTC progressed slowly with an overall favorable prognosis. However, in mid to advanced-stage PTC, as tumor stage increased, disease progression accelerated, and prognosis gradually worsened. Age, tumor stage, marital status, and gender were independent risk factors influencing the prognosis of untreated PTC, and the nomogram based on these factors demonstrated good prognostic capability.
Do you feel me? Autism, empathic accuracy and the double empathy problem
Authors: Cheang Rachael TS , Skjevling Maya , Blakemore Alexandra IF , Kumari Veena , Puzzo Ignazio 
Published: May 2024

Empathy deficits in autism, particularly cognitive empathy, have been a long-held, but much debated assumption. An alternative perspective challenging this deficit model is the ‘double empathy problem’, proposing that empathy difficulties are bidirectional between autistic and non-autistic people. Despite this view gaining popularity, there has been limited research examining whether non-autistic people can empathise accurately, cognitively and affectively with autistic people. Addressing this gap, 81 adults from the general population, divided into groups based on how likely they are to share personality traits common in autistic people, were examined using an empathic accuracy task, modified to include autistic and non-autistic narrators and combined with a body mapping tool. Results showed participants had significantly lower empathic accuracy scores when viewing autobiographical accounts of emotional events from autistic narrators, compared to non-autistic narrators, especially for happy and sad emotions. However, participants also experienced significantly higher intensity in the body when viewing autistic narrators compared to non-autistic narrators, especially for anger and fear emotions. These findings support the double empathy problem and have strong implications for therapeutic and interpersonal relationships with autistic people. Lay Abstract The assumption that autistic people lack empathy, particularly imagining how others feel, has been much debated and is now being challenged by an alternative view: the ‘double empathy problem’. This suggests that non-autistic people may find it equally difficult to imagine how autistic people feel. Although this perspective is gaining popularity, research testing whether non-autistic people can accurately imagine and feel an autistic person’s emotions is still limited. Our study used video clips of autistic and non-autistic people recounting emotional events to test if participants from the general population could: track the intensity of the narrators’ emotions; name and feel the same emotion; match where the narrator felt the emotion and indicate how intensely they felt the emotion using a body map. Our results show that participants found it significantly harder to track autistic narrators’ emotions compared to non-autistic narrator’s emotions, especially when viewing clips of narrators feeling happy and sad. We also found that participants felt emotions more intensely in the body when viewing clips of autistic narrators compared to non-autistic narrators, especially when describing anger and fear. These findings support the double empathy problem and have strong implications for therapeutic and interpersonal relationships with autistic people.
Experimental study on filtration performance of geotextile filter used in emergency rescue of dike piping
Authors: Feng Di , Jiang Shi Lai , Liu Sheng 
Published: May 2024

Geotextiles, as a type of common filtration material, have broad prospects in emergency rescue of dike backward erosion piping (BEP). To investigate the filtration performance of geotextile in BEP emergency rescue, several experiments were conducted using nonwoven and woven geotextiles to simulate the process of rescuing BEP with geotextiles. The influence of geotextile specifications and types on hydraulic compatibility of the filter system was analyzed, and the clogging mechanism of geotextile during dealing with BEP was revealed at a microscopic level. The results showed that the nonwoven geotextile filter with an equivalent pore size of 0.103 mm had a gradient ratio value of less than 3, and it had a highest flow rate of 260 mL/min. Increasing the thickness and pore size of nonwoven geotextiles within a certain range helped enhance their anti-clogging ability. The main mechanism of clogging in nonwoven geotextiles was the deposition of fine sand particles on their surface, forming a layer of low permeability soil. Plain woven geotextiles experienced severe clogging with a 42% reduction in flow rate, and it was not suitable for rescuing BEP. The clogging mechanism of woven geotextile involved the blocking of horizontal water passages by fine sand particles.
Examining workplace behaviors in adult women with urinary incontinence: A pilot study
Authors: Brock Catherine , Elliott Samantha , Miller Sarah , Polomsky Riley , Shoemaker Brooke , Sullivan Megan 
Published: May 2024

Background: Urinary incontinence is a growing issue among adult women globally. Limited data exist examining the impact of occupational, environmental, and behavioral factors on urinary incontinence. Objective: This quantitative, cross-sectional pilot study examined the workplace behaviors of adult women experiencing urinary incontinence. It was hypothesized that specific jobs and work environments would be associated with increased urinary incontinence and urgency based on identified behaviors and work-related conditions. Design: This study is a quantitative, cross-sectional survey. Methods: Adult women (18 years and older) with a history of urinary incontinence were recruited from August 2022 to February 2023 to complete a one-time survey consisting of multiple-choice and short answer questions identifying specific workplace behaviors and symptoms of urinary incontinence. Descriptive statistics and data categorization were used to observe outcomes and examine relationships between urinary incontinence and particular professions. Results: Urinary incontinence and urgency-related symptoms affected healthcare and business professionals at a higher prevalence. The most commonly reported behaviors across all professions consisted of withholding urine and utilizing absorbance products. Conclusion: The results of this study will help guide women’s health practitioners in exploring current workplace behaviors that may contribute to urinary incontinence in adult women. With this knowledge, practitioners can provide meaningful education to employers and employees to prioritize toileting behaviors in the workplace.
Temporary hemi-epiphysiodesis with tension band plates in skeletally immature patients with genu valgum: Faster correction in patients with more than 2 years of expected time of growth remaining
Authors: Salvato Damiano , Chipman Danielle E. , Cirrincione Peter , Hawes Joseph , Lijesen Emilie , Green Daniel W. 
Published: May 2024

Purpose: Hemi-epiphysiodesis procedures in skeletally immature patients are commonly done to correct genu valgum over time. This study seeks to demonstrate the average rate of deformity correction for genu valgum using hinged tension band plates, while examining different age groups and sex-related differences. Methods: A retrospective chart review of patients who underwent hemi-epiphysiodesis with hinged tension band plates for valgus knee deformity from 2012 to 2022 by one pediatric orthopaedic surgeon was performed. Expected time of growth remaining was calculated as the difference between age of skeletal maturity and bone age at time of surgery. The mechanical lateral distal femoral angle, mechanical medial proximal tibial angle, mechanical femoral tibia angle, screw divergence angle, and hinge angle were measured immediately after implant placement and prior to implant removal. Results: 54 skeletally immature patients were treated for pathologic genu valgum. The mean age at time of surgery was 12.5 ± 1.9 years. The radiographic measurement of the valgus deformity between the beginning and end of treatment showed significant correction ( p = 0.002). The lower limb axis of the younger cohort corrected significantly faster (7.5 ± 4.6°/year) than the older cohort (5.3 ± 2.8°/year) ( p = 0.030). The mechanical lateral distal femoral angle correction rate was also significantly different between the two cohorts (7.0 ± 4.7°/year vs. 4.8 ± 2.8°/year, respectively ( p = 0.002)). The group with greater expected time of growth remaining demonstrated a significantly faster rate of correction than the group with less than 2 years of growth remaining ( p < 0.001). Conclusion: This study reaffirms the finding that timing is essential when performing temporary hemi-epiphysiodesis for valgus knee deformity in skeletally immature patients.
Quality of Life After Head and Neck Cancer Surgery and Free Flap Reconstruction: A Systematic Review
Authors: Gosselin Laura-Elisabeth , Villemure-Poliquin Noémie , Audet Nathalie 
Published: May 2024

Background Different factors can affect the quality of life of patients treated for head and neck cancer undergoing major surgical intervention. However, it remains unclear which specific factors and what possible interventions could have the greatest influence on quality of life postoperatively for patients undergoing surgical resection with free flap reconstruction. The objective of our systematic review was to identify which factors, at the time of surgical treatment, are associated with a worse postoperative quality of life for patients undergoing surgical resection with free flap reconstruction for head and neck cancer. Methods We performed a systematic review of MEDLINE, Embase, CINAHL, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL), from their inception through November 2021. We included peer reviewed studies that evaluated the impact of specific factors on quality of life for adult patients who underwent surgery with free flap reconstruction for head and neck cancer. Two reviewers independently screened citations for eligibility and extracted data. Risk of bias of each study was evaluated using the New-Castle Ottawa Scale. Vote counting and qualitative review were used to synthesize results. All relevant findings were reported. Results We initially identified 1971 articles. We included 22 articles in our systematic review, totaling 1398 patients. There was a high level of variability for factors evaluated throughout studies and many studies presented small sample sizes. However, some factors were associated with worse long-term quality of life, including older age, radiotherapy, higher tumor stage, dysphagia, anxiety as well as depressive symptoms. Very few articles analyzed their data for specific tumor subsites and the impact of psychosocial factors was rarely evaluated throughout studies. Conclusions For patients with head and neck cancer requiring free flap reconstruction, some specific factors may correlate with changes in quality of life. However, these findings are based on very few and mostly underpowered studies. A better understanding of factors affecting quality of life could allow a more personalized and overall better quality of care for patients.
Mechanistic Evaluation of Antiarthritic Effects of Eupatilin in CFA-Induced Arthritic Rats: An in Vivo and in Silico Study
Authors: Wang Lichun , Liu Jie , Zhang HongLi , Cheng Guangyu 
Published: May 2024

Objectives In the present study, we explored the antiarthritic potential of Eupatilin on complete Freund's adjuvant (CFA)-induced arthritis rats. Materials and Methods In order to induce arthritis in the Sprague-Dawley rats, CFA vaccination was used, and Eupatilin was given to the rats at dose of 5, 10, and 20 mg/kg. Various biochemical and other parameters were studied to define the pharmacological benefit of Eupatilin. Results The study's findings revealed that Eupatilin increases rats’ body weight and significantly reduces hind paw volume. It also improves the antioxidant status of CFA rats by lowering malondialdehyde levels and increasing the concentration of endogenous antioxidants superoxide dismutase and GPx. Eupatilin also improved hematological markers, which were demonstrated to be altered in CFA rats as compared to the control. In the Eupatilin-treated group, the level of pro-inflammatory cytokines was found to be reduced as compared to CFA rats. In a molecular docking analysis, it showed favorable interaction with the active site of cyclooxygenase-2 (COX-2) by the formation of numerous nonbonded interactions by interacting with Cys32, Leu138, Pro 139, Val141, Ala142, and Cys145. It also showed a Vina score of −9.4 and interacts with the cavity volume of 4435 Å3. Conclusion Eupatilin showed favorable antiarthritic benefits in the CFA-induced arthritis model, as evidenced by reductions in paw volume, significant weight loss prevention, and maintenance of the healthy hematological and biochemical profile may be through inhibiting COX-2.
Feasibility of a Hospital-Based Kitchen Garden
Authors: Carroll Chloe , McCray Sally , Utter Jennifer 
Published: May 2024

Aim: To explore the chef’s experience with a newly implemented indoor hospital-based kitchen garden designed to supplement herbs ordered for patient meals and improve staff engagement. Background: Hospital-based therapeutic and kitchen gardens have emerged as effective health-promoting tools in hospital healthcare environments. They promote emotional, mental, and physical well-being for patients, visitors, and staff. However, formal evaluations are limited, and studies focusing on indoor hospital kitchen gardens are noticeably absent in the literature. Methods: Qualitative evaluation of a hospital-based kitchen garden. Open-ended interviews were conducted approximately 6 months after garden implementation and explored key informants ( n = 6) overall experience, engagement with the garden, perceived benefits, and opportunities for improvement. Interview data was analyzed using a thematic approach. Results: The implementation of the kitchen gardens was met with overall acceptance among staff. However, the project’s feasibility faced challenges related to local food service leadership, communication, and certain aspects of the garden setup. Despite these obstacles, the gardens contributed positively to the quality of meals by including fresh herbs and fostering greater staff engagement. Conclusions: The chefs viewed the concept of the hospital-based kitchen garden favorably, noting that it closely aligned with their mission of providing nutritious meals to patients. However, consideration of the broader issues facing hospital food services may be required to seamlessly integrate this task into the kitchen staff’s daily routine. Further research is warranted to investigate the effective implementation and feasibility of indoor kitchen gardens in hospitals and their impact on patient menus, food service staff, and the workforce.
Survey of radiologists on work from home: Using the results to plan a hybrid work model
Authors: Lee Emma Choon Hwee , Hou Wenlu , Karande Gita Yashwantrao , Chan Lai Peng , Lai Keefe Yusheng 
Published: May 2024

Background The COVID-19 pandemic saw many radiology departments worldwide adopting work from home (WFH) practices for social distancing and operational resilience. This paper explores the attitudes and perceptions of radiologists on WFH in Singapore. Methods A survey was conducted amongst radiologists at a large tertiary hospital in Singapore from 1 August 2022 to 1 September 2022. Topics included whether they met pre-requisites for WFH, the preferred frequency of WFH, equitability, and perceived impact on joy at work, resident training, and talent recruitment and retention. Results were analysed for significant associations with respondent demographics. Results There was an 88% response rate (49/56). 78% met pre-requisites for WFH. Most radiologists preferred a hybrid arrangement of WFH up to 2 days a week (70%) with 15-20% of their team WFH at any one time. Majority of radiologists wished to WFH when providing out-of-hours coverage (76%). There was perceived positive impact of WFH on individual joy at work (mean rating: 4.1), team joy at work (mean rating: 3.5) and talent recruitment and retention (mean rating: 4.0). Perceived impact on radiology resident training was negative to neutral (mean rating: 2.8). Free-text responses revealed concerns about equitability, WFH setup, training, and collegial relationships. Statistically significant differences in responses were found between genders and radiologists who met pre-requisites versus those who didn’t. Conclusion Our radiologists prefer a hybrid WFH model and anticipate it will increase joy at work and talent recruitment and retention. A hybrid WFH model may help address and mitigate some of the potential negative effects of WFH.