bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Stretchable, Sweat‐Resistant Electrophoretic Display Device Driven by Human‐Safe Voltage for Smart E‐Textile Application
Authors: Zhu Simu , Xiong Feng , Gu Yifan , Wang Ting , Lu Hao , Qiu Zhiguang , Yang Bo‐Ru , Deng Shaozhi 
Published: June 2024

AbstractThe demand for wearable display devices capable of real‐time information collection is growing rapidly. Among them, electrophoretic display (EPD) shows features of ultra‐low power consumption and high readability in sunlight, making them particularly suitable for wearable applications. However, due to high driving voltage and susceptibility to salt, few wearable EPD devices are reported so far. To address this, a stretchable EPD compatible with textiles is fabricated based on waterborne polyurethane. The device exhibits great performance to resist water and sweat, achieving a whiteness of 35 (Y in CIE XYZ) and a contrast ratio of 13.5 at a driving voltage of 30 V. Benefit from the device's excellent bistability and flexibility, there is no degrading to its optoelectronic performance after bending, twisting or stretching. For demonstration, an 8 × 8 matrix display is realized, showcasing that this process is suitable for wearable textile display applications.
CH3NH3SnI3${\mathrm{CH}}_{\mathrm{3}}{\mathrm{NH}}_{\mathrm{3}}{\mathrm{SnI}}_{\mathrm{3}}$: Superior Light Absorption and Optimized Device Architecture with 31.93% Efficiency
Authors: Hajjami M. , Chabri I. , Oubelkacem A. , Benhouria Y. , Kaiba A. , Essaoudi I. , Ainane A. 
Published: June 2024

AbstractThis research investigates and optimizes the perovskite solar cells. Initially, optoelectronic parameters of perovskite absorber materials, including , , and , are estimated using Density Functional Theory (DFT) principles implemented in the Quantum Espresso software. The absorption of light energy is examined, detailing electron transitions between the highest p energy states of halogens (I, Br, and Cl) in the VB and the lowest 5p energy states of tin in the CB. shows superior optical characteristics, surpassing and , and demonstrating more effective absorption within the visible spectrum than . Subsequently, a numerical analysis is conducted for a P–I–N configuration Fluorine doped Tin Oxide (FTO)////Anode using SCAPS‐1D software. The optimization process focuses on absorber thickness, defect density, acceptor density, and the work function (WF) of the anode materials. Simulation findings recommend a defect density () of for optimal performance, coupled with an absorber thickness of 1 µm. Examining the transformation from to through oxidation reveals that reducing the concentration of acceptors in the absorber layer (NA) significantly enhances device performance. Superior performance is achieved by a high WF anode material. This study not only contributes to advancing our understanding of lead‐free perovskite optoelectronics but also provides valuable insights for the development of highly efficient and stable solar cells.
Targeting Rab7‐Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy
Authors: Ke Jiahan , Pan Jianan , Lin Hao , Huang Shuying , Zhang Junfeng , Wang Changqian , Chang Alex Chia Yu , Gu Jun 
Published: June 2024

AbstractDiabetic cardiomyopathy (DbCM) is characterized by diastolic dysfunction, which progresses into heart failure and aberrant electrophysiology in diabetic patients. Dyslipidemia in type 2 diabetic patients leads to the accumulation of lipid droplets (LDs) in cardiomyocytes and results in lipid toxicity which has been suggested to drive DbCM. It is aimed to explore potential pathways that may boost LDs degradation in DbCM and restore cardiac function. LDs accumulation resulted in an increase in lipid toxicity in DbCM hearts is confirmed. Microlipophagy pathway, rather than traditional macrolipophagy, is activated in DbCM hearts. RNA‐Seq data and Rab7‐CKO mice implicate that Rab7 is a major modulator of the microlipophagy pathway. Mechanistically, Rab7 is phosphorylated at Tyrosine 183, which allows the recruitment of Rab‐interacting lysosome protein (Rilp) to proceed LDs degradation by lysosome. Treating DbCM mice with Rab7 activator ML‐098 enhanced Rilp level and rescued the observed cardiac dysfunction. Overall, Rab7‐Rilp‐mediated microlipophagy may be a promising target in the treatment of lipid toxicity in DbCM is suggested.
Regulation of Interface Ion Transport by Electron Ionic Conductor Construction toward High‐Voltage and High‐Rate LiNi0.5Co0.2Mn0.3O2 Cathodes in Lithium Ion Battery
Authors: Tian Yunan , Li Yuyu , Shen Huasen , Cheng Xiangxin , Cheng Yiming , Zhang Wen , Yu Peng , Yang Zehui , Xue Lixing , Fan Yameng , Zhao Lingfei , Peng Jian , Wang Jiazhao , Li Zhaohuai , Xie Ming , Liu Huakun , Dou Shixue 
Published: June 2024

AbstractSimultaneously achieving high‐energy‐density and high‐power‐density is a crucial yet challenging objective in the pursuit of commercialized power batteries. In this study, atomic layer deposition (ALD) is employed combined with a coordinated thermal treatment strategy to construct a densely packed, electron‐ion dual conductor (EIC) protective coating on the surface of commercial LiNi0.5Co0.2Mn0.3O2 (NCM523) cathode material, further enhanced by gradient Al doping (Al@EIC‐NCM523). The ultra‐thin EIC effectively suppresses side reactions, thereby enhancing the stability of the cathode‐electrolyte interphase (CEI) at high‐voltages. The EIC's dual conduction capability provides a potent driving force for Li+ transport at the interface, promoting the formation of rapid ion deintercalation pathways within the Al@EIC‐NCM523 bulk phase. Moreover, the strategic gradient doping of Al serves to anchor the atomic spacing of Ni and O within the structure of Al@EIC‐NCM523, curbing irreversible phase transitions at high‐voltages and preserving the integrity of its layered structure. Remarkably, Al@EIC‐NCM523 displays an unprecedented rate capability (114.7 mAh g−1 at 20 C), and a sustained cycling performance (capacity retention of 74.72% after 800 cycles at 10 C) at 4.6 V. These findings demonstrate that the proposed EIC and doping strategy holds a significant promise for developing high‐energy‐density and high‐power‐density lithium‐ion batteries (LIBs).
Tailoring rectal cancer surgery: Surgical approaches and anatomical insights during deep pelvic dissection for optimal outcomes in low‐lying rectal cancer
Authors: Park Youn Young , Kim Nam Kyu 
Published: June 2024

AbstractThis review article explores advanced surgical approaches and anatomical insights for tailoring rectal cancer surgery, particularly focusing on low‐lying rectal cancer. With the evolution of imaging technologies, precise preoperative planning has become possible, enhancing the visualization of anatomy surrounding the rectum and enabling more accurate assessments of circumferential resection margin (CRM) involvement. The article emphasizes the dynamic nature of rectal cancer treatment, advocating for individualized surgical planning based on comprehensive preoperative imaging and intraoperative assessment. This approach aims to optimize patient care by integrating recent advancements and anatomical insights into clinical practice for the management of low‐lying rectal cancer. Particularly, the article discusses the importance of customizing the excision of Denonvilliers' fascia (DVF) based on tumor characteristics for optimal oncologic and functional outcomes, especially for anteriorly located tumors. It highlights the need for precise dissection techniques to ensure a negative CRM while preserving critical anatomical structures. Additionally, the review addresses the surgical management of tumors at the anorectal ring and introduces the Gate Approach for deep anterolateral pelvic dissection. Special attention is given to tumors impacting the membranous and prostate urethra, emphasizing tailored surgical approaches to balance complete tumor resection with the preservation of urogenital functions.
Metal‐ and Photocatalyst‐Free Aerobic Photoinduced Benzyl C(sp3)−H Bonds Oxidation
Authors: Wang Peng , Gao Wei , Chen Maoqiang , Ge Yuyang , Ma Li , Wang Ling , Guo Bingpeng , Zhao Zhengfeng , Zhou Jianhua , Tan Xuejie , Li Yuehui , Liu Zunqi , Chen Jianbin 
Published: June 2024

AbstractPhotoinduced the direct oxidation of benzyl C(sp3)−H bonds provides an attractive strategy for producing high‐value chemicals or intermediates. Unlike the conventional approaches that typically require transition‐metal catalysts, semiconductors, and organic photosensitizers as the photocatalysts, herein we report a bromine salt‐promoted photoinduced aerobic oxidation protocol for methylarenes. By applying NH4Br as both the bromine radical source and hydrogen atom transfer agent, photoinduced oxidation of methylarenes to the corresponding carboxylic products exhibits high conversion and selectivity. Furthermore, control experiments confirm that reactive oxygen species are proved to be essential for the success of this transformation. This strategy provides a metal‐/strong oxidant‐/photocatalyst‐free paradigm for the direct deep oxidation of methylarenes.
A Radical Activation Strategy for Versatile and Stereoselective N‐Glycosylation
Authors: Ding Wenyan , Chen Xinyu , Sun Zuyao , Luo Jiaxin , Wang Shiping , Lu Qingqing , Ma Jialu , Zhao Chongxin , Chen Fen‐Er , Xu Chunfa 
Published: June 2024

AbstractPrevious N‐glycosylation approaches have predominately involved acidic conditions, facing challenges of low stereoselectivity and limited scope. Herein, we introduce a radical activation strategy that enables versatile and stereoselective N‐glycosylation using readily accessible glycosyl sulfinate donors under basic conditions and exhibits exceptional tolerance towards various N‐aglycones containing alkyl, aryl, heteroaryl and nucleobase functionalities. Preliminary mechanistic studies indicate a pivotal role of iodide, which orchestrates the formation of a glycosyl radical from the glycosyl sulfinate and subsequent generation of the key intermediate, a configurationally well‐defined glycosyl iodide, which is subsequently attacked by an N‐aglycone in a stereospecific SN2 manner to give the desired N‐glycosides. An alternative route involving the coupling of a glycosyl radical and a nitrogen‐centered radical is also proposed, affording the exclusive 1,2‐trans product. This novel approach promises to broaden the synthetic landscape of N‐glycosides, offering a powerful tool for the construction of complex glycosidic structures under mild conditions.
Peripheral (E)‐2‐[(4‐hydroxybenzylidene)‐3,4‐dihydronaphthalen‐1(2H)‐one)]‐coordinated phthalocyanines with improved enzyme inhibition properties and photophysicochemical behaviors
Authors: Güleç Özcan , Bilgiçli Ahmet T. , Tüzün Burak , Taslimi Parham , Günsel Armağan , Gülçin İlhami , Arslan Mustafa , Yarasir M. Nilüfer 
Published: June 2024

AbstractIn this study, (E)‐4‐{4‐[(1‐oxo‐3,4‐dihydronaphthalen‐2(1H)‐ylidene)methyl]phenoxy}phthalonitrile (4) and its phthalocyanine derivatives (5–8) were synthesized for the first time. Aggregation behaviors of the novel soluble phthalocyanines in organic solvents were investigated. In addition, the efficiency of 1O2 production of (5) and ZnPc (6) was investigated. The singlet oxygen quantum yields (ΦΔ) for 2HPc (5) and ZnPc (6) were found to be 0.58 and 0.83, respectively. Additionally, novel phthalocyanines (5–8) were investigated for their ability to inhibit enzymes. They exhibited a highly potent inhibition effect on human carbonic anhydrase I and II (hCA I and II) and α‐glycosidase (α‐Gly) enzymes. Ki values are in the range of 2.60 ± 9.87 to 11.53 ± 6.92 µM, 3.35 ± 0.53 to 15.47 ± 1.20 µM, and 28.60 ± 4.82 to 40.58 ± 7.37 nM, respectively. The calculations of the studied molecule at the B3LYP, HF, and M062X levels in the 6–31G basis sets were made using the Gaussian package program. Afterward, the interactions occurring in the docking calculation against a protein that is the crystal structure of hCA I (PDB ID: 2CAB), the crystal structure of hCA II (PDB ID: 5AML), and the crystal structure of α‐Gly (PDB ID: 1R47), were examined. Following that, Protein–Ligand Interaction Profiler (PLIP) analysis was used to look at the interactions that occurred during the docking calculation in further detail.
Unlocking nitrogen compounds’ promise against malaria: A comprehensive review
Authors: Kuthe Pranali Vijaykumar , Muzaffar‐Ur‐Rehman Mohammad , Chandu Ala , Prashant Kirad Shivani , Sankarnarayanan Murugesan 
Published: June 2024

AbstractPlasmodium parasites are the primary cause of malaria, leading to high mortality rates, which require clinical attention. Many of the medications used in the treatment have resulted in resistance over time. Artemisinin combination therapy (ACT) has shown significant results for the treatment. However, mutations in the parasite have resulted in resistance, leading to decreased efficiency of the medications that are currently being used. Therefore, there is a critical need to find novel scaffolds that are safe, effective, and of economic advantage. Literature has reported several potent molecules with diverse scaffolds designed, synthesized, and evaluated against different strains of Plasmodium. With this growing list of compounds, it is essential to collect the data in one place to gain a concise overview of the emerging scaffolds in recent years. For this purpose, nitrogen‐containing heterocycles such as β‐carboline, imidazole, quinazoline, quinoline, thiazole, and thiophene have been highly explored due to their wide biological applications. Besides these, another scaffold, benzodiazepine, which is majorly used as a central nervous system depressant, is emerging as an anti‐malarial agent. Hence, this review centers on the latest medication advancements designed to combat malaria, emphasizing special attention to 1,4‐benzodiazepines as a novel scaffold for antimalarial drug discovery.
A novel standard‐free detection of adulteration method for sildenafil derivatives in dietary supplements
Authors: Lv Diya , Wang Dongyao , Li Dan , Guo Dandan , Qi Minyu , Zhang Ying , Chai Yifeng , Chen Xiaofei , Cao Yan 
Published: June 2024

AbstractThe rapid and accurate detection of illegal adulteration of chemical drugs into dietary supplements is a big challenge in the food chemistry field. Detection of compounds without a standard reference is even more difficult; however, this is a common situation. Here in this study, a novel “standard‐free detection of adulteration” (SFDA) method was proposed and phosphodiesterase‐5 inhibitor derivatives were used as an example to figure out the possibility and reliability of this SFDA method. After analysis by quadrupole coupled time of flight–tandem mass spectrometry detection and multivariable statistics, six common fragment ions were chosen to indicate whether adulteration was present or not, while 20 characteristic fragment ions indicated whether adulteration was by nitrogen‐containing heterocycles or by anilines. Furthermore, the quantitative methods were conducted by high‐performance liquid chromatography–tandem mass spectrometry. In a word, this strategy allows for a quick determination of dietary supplement adulteration without any need for standard materials, improving the efficacy of food safety testing.
A language‐directed virtual human motion generation approach based on musculoskeletal models
Authors: Sun Libo , Wang Yongxiang , Qin Wenhu 
Published: June 2024

AbstractThe development of the systems capable of synthesizing natural and life‐like motions for virtual characters has long been a central focus in computer animation. It needs to generate high‐quality motions for characters and provide users with a convenient and flexible interface for guiding character motions. In this work, we propose a language‐directed virtual human motion generation approach based on musculoskeletal models to achieve interactive and higher‐fidelity virtual human motion, which lays the foundation for the development of language‐directed controllers in physics‐based character animation. First, we construct a simplified model of musculoskeletal dynamics for the virtual character. Subsequently, we propose a hierarchical control framework consisting of a trajectory tracking layer and a muscle control layer, obtaining the optimal control policy for imitating the reference motions through the training. We design a multi‐policy aggregation controller based on large language models, which selects the motion policy with the highest similarity to user text commands from the action‐caption data pool, facilitating natural language‐based control of virtual character motions. Experimental results demonstrate that the proposed approach not only generates high‐quality motions highly resembling reference motions but also enables users to effectively guide virtual characters to perform various motions via natural language instructions.
Diagnostic, predictive and prognostic molecular biomarkers in clear cell renal cell carcinoma: A retrospective study
Authors: Deng Jian , Tu ShengYuan , Li Lin , Li GangLi , Zhang YinHui 
Published: June 2024

AbstractClear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of kidney cancer. Many patients are diagnosed at advanced stages, making early detection crucial. Unfortunately, there are currently no noninvasive tests for ccRCC, emphasizing the need for new biomarkers. Additionally, ccRCC often develops resistance to treatments like radiotherapy and chemotherapy. Identifying biomarkers that predict treatment outcomes is vital for personalized care. The integration of artificial intelligence (AI), multi‐omics analysis, and computational biology holds promise in bolstering detection precision and resilience, opening avenues for future investigations. The amalgamation of radiogenomics and biomaterial‐basedimmunomodulation signifies a revolutionary breakthrough in diagnostic medicine. This review summarizes existing literature and highlights emerging biomarkers that enhance diagnostic, predictive, and prognostic capabilities for ccRCC, setting the stage for future clinical research.
Teaching Green Chemistry and Engineering through the Epoxidation of Poly‐β‐myrcene
Authors: Anastasiou Dimitrios E. 
Published: June 2024

AbstractThis study explores the application of the epoxidation process of poly‐β‐myrcene, a constituent of the natural resin from Chios Mastic trees (Pistacia Lentiscus L.), as an educational instrument for teaching Green Chemistry and Engineering to students at various academic levels. The study provides a comprehensive presentation of foundational knowledge essential for interpreting the subsequent experimental data. Consequently, the production process that leads to the production of Mastic Epoxide (MASTEP) stands as an invaluable pedagogical resource, enabling educators to impart crucial principles of Green Chemistry and Engineering to both pre‐graduate and post‐graduate students. By employing MASTEP as a case study, this educational approach actively involves students in a dynamic learning environment. Through this methodology, learners develop a profound comprehension of sustainability, innovation, and good practices. The integration of the MASTEP concept into the curriculum would foster a deeper understanding of responsible methodologies among aspiring chemical engineers and scientists, equipping them to make substantial contributions towards a more sustainable global landscape. This educational model aims to contribute to preparing future generations for a pivotal role in fostering a sustainable world through their professional endeavors.
A Scale for Measuring Positive and Negative Experiences of Psychotherapy (PNEP): First Psychometric Findings of a New Instrument for Monitoring Clients' Experiences
Authors: Dandachi‐FitzGerald Brechje , Houben Sanne T. L. , Broers Nick J. , Merckelbach Harald 
Published: June 2024

ABSTRACTBackgroundClients' adverse experiences during psychotherapy are rarely monitored in clinical practice or research trials. One obstacle here is the lack of a measure to gauge both positive and negative experiences during psychotherapy. We developed and evaluated a new instrument for measuring such experiences.MethodThe Positive and Negative Experiences of Psychotherapy (PNEP) questionnaire was developed based on pilot data, a literature review, and two existing scales for measuring primarily adverse experiences during psychotherapy. Mental healthcare clients (N = 200) anonymously completed and evaluated the PNEP. Subsequently, a sample of professionals (N = 34) who underwent psychotherapy in the context of their training filled in the PNEP twice, with a 2‐week interval in between.ResultsThe positive and negative experiences subscales of the PNEP were found to possess excellent internal consistencies (αs ≥ 0.90). The PNEP test–retest reliability was 0.93 for the positive experiences subscale and 0.78 for the negative experiences subscale. For the positive subscale, four factors were extracted: symptom reduction and positive well‐being, high quality of therapy and therapeutic relation, personal growth and acceptance and interpersonal functioning. For the negative subscale, exploratory factor analysis suggested a three‐factor solution: escalation of symptoms and emotional distress, low quality of therapy and therapeutic relation and (self‐)stigmatization and dependency. Participants related a median of 13 positive and six negative therapy experiences to their most recent treatment. The most frequently endorsed negative experiences were having more negative thoughts and memories, feeling emotionally overwhelmed and an increase in stress due to the therapy. A minority of participants (10.5%) reported no negative treatment experiences.ConclusionsIn the field of psychotherapy, the evaluation of risks and benefits is crucial for assessing safety and effectiveness. The PNEP could be a promising instrument for achieving this objective, although further research is needed to replicate and expand upon the current findings.
A C‐terminal motif containing a PKC phosphorylation site regulates γ‐Protocadherin‐mediated dendrite arborization in the cerebral cortex in vivo
Authors: Hanes Camille M. , Mah Kar Men , Steffen David M. , McLeod Cathy M. , Marcucci Charles G. , Fuller Leah C. , Burgess Robert W. , Garrett Andrew M. , Weiner Joshua A. 
Published: June 2024

AbstractThe Pcdhg gene cluster encodes 22 γ‐Protocadherin (γ‐Pcdh) cell adhesion molecules that critically regulate multiple aspects of neural development, including neuronal survival, dendritic and axonal arborization, and synapse formation and maturation. Each γ‐Pcdh isoform has unique protein domains—a homophilically interacting extracellular domain and a juxtamembrane cytoplasmic domain—as well as a C‐terminal cytoplasmic domain shared by all isoforms. The extent to which isoform‐specific versus shared domains regulate distinct γ‐Pcdh functions remains incompletely understood. Our previous in vitro studies identified protein kinase C (PKC) phosphorylation of a serine residue within a shared C‐terminal motif as a mechanism through which γ‐Pcdh promotion of dendrite arborization via myristoylated alanine‐rich C‐kinase substrate (MARCKS) is abrogated. Here, we used CRISPR/Cas9 genome editing to generate two new mouse lines expressing only non‐phosphorylatable γ‐Pcdhs, due either to a serine‐to‐alanine mutation (PcdhgS/A) or to a 15‐amino acid C‐terminal deletion resulting from insertion of an early stop codon (PcdhgCTD). Both lines are viable and fertile, and the density and maturation of dendritic spines remain unchanged in both PcdhgS/A and PcdhgCTD cortex. Dendrite arborization of cortical pyramidal neurons, however, is significantly increased in both lines, as are levels of active MARCKS. Intriguingly, despite having significantly reduced levels of γ‐Pcdh proteins, the PcdhgCTD mutation yields the strongest phenotype, with even heterozygous mutants exhibiting increased arborization. The present study confirms that phosphorylation of a shared C‐terminal motif is a key γ‐Pcdh negative regulation point and contributes to a converging understanding of γ‐Pcdh family function in which distinct roles are played by both individual isoforms and discrete protein domains.