bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum concentrations of insulin‐like growth factor‐i and insulin‐like growth factor binding protein‐2 and ‐3 in eight hoofstock species
Authors: Govoni Kristen E. , Goodman Danielle , Maclure Rebecca M. , Penfold Linda M. , Zinn Steven A. 
Published: September 2010

AbstractThe somatotropic axis, which includes growth hormone, insulin‐like growth factor (IGF)‐I, and IGF binding proteins (IGFBP), is involved in the regulation of growth and metabolism. Measures of the somatotropic axis can be predictive of nutritional status and growth rate that can be utilized to identify nutritional status of individual animals. Before the somatotropic axis can be a predictive tool, concentrations of hormones of the somatotropic axis need to be established in healthy individuals. To begin to establish these data, we quantified IGF‐I, IGFBP‐2, and IGFBP‐3 in males and females of eight threatened hoofstock species at various ages. Opportunistic blood samples were collected from Bos javanicus (Java banteng), Tragelaphus eurycerus isaaci (bongo), Gazella dama ruficollis (addra gazelle), Taurotragus derbianus gigas (giant eland), Kobus megaceros (Nile lechwe), Hippotragus equines cottoni (roan antelope), Ceratotherium simum simum (white rhinoceros), and Elephas maximus (Asian elephant). Serum IGF‐I and IGFBPs were determined by radioimmunoassay and ligand blot, respectively. Generally, IGF‐I and IGFBP‐3 were greater in males, and IGFBP‐2 was greater in females. In banteng (P = 0.08) and male Nile lechwe (P<0.05), IGF‐I increased with age, but decreased in rhinoceros (P = 0.07) and female Nile lechwe (P<0.05). In banteng, IGFBP‐3 was greater (P<0.01) in males. In elephants (P<0.05) and antelope (P = 0.08), IGFBP‐2 were greater in females. Determination of concentrations of hormones in the somatotropic axis in healthy animals makes it possible to develop models that can identify the nutritional status of these threatened hoofstock species. Zoo Biol 30:275–284, 2011. © 2010 Wiley‐Liss, Inc.
Case report: long‐term outcome post‐heart transplantation in a woman with Fabry's disease
Authors: Verocai Flavia , Clarke Joe Thomas , Iwanochko Robert M. 
Published: September 2010

AbstractFabry's disease is an X‐linked recessive disorder that results from the deficiency of alpha‐galactosidase A and causes the accumulation of globotriaosylceramide (Gb3) in different tissues. It leads to a rare form of cardiomyopathy which may be complicated by end‐stage heart failure and need to heart transplant. Our group described the first case of heart transplant in a woman with cardiomyopathy secondary to Fabry's disease about 12 years ago. There was uncertainty in regards to the possibility of recurrence of the disease as previously documented in kidney transplant recipients and long‐term outcomes. In this report, 14 years after transplant, this woman is still alive and there is no evidence of Fabry's disease in any of the endomyocardial biopsies. Heart transplantation can be recommended for Fabry's patients with end‐stage cardiomyopathy.
Cerebrospinal fluid alterations of the serotonin product, 5‐hydroxyindolacetic acid, in neurological disorders
Authors: De Grandis Elisa , Serrano Mercedes , Pérez‐Dueñas Belén , Ormazábal Aida , Montero Raquel , Veneselli Edvige , Pineda Mercè , González Verónica , Sanmartí Francesc , Fons Carmen , Sans Anna , Cormand Bru , Puelles Luis , Alonso Antonia , Campistol Jaime , Artuch Rafael , García‐Cazorla Angels 
Published: September 2010

AbstractAlthough patients with low cerebrospinal fluid (CSF) serotonin metabolite levels have been reported, inborn errors of the rate‐limiting enzyme of serotonin synthesis (tryptophan hydroxylase, TPH) have not been described so far. In this study we aimed to evaluate CSF alterations of the serotonin metabolite 5‐hydroxyindolacetic acid (5‐HIAA) in patients with neurological disorders and to explore a possible TPH deficiency in some of them. A total of 606 patients (286 males, 320 females, mean age 4 years and 6 months, SD 5 years and 7 months) underwent CSF analysis of neurotransmitter metabolites by reverse phase high performance liquid chromatography. Results were compared with values established in a control population. Patients’ medical records were reviewed to determine diagnosis and clinical features. A primary defect of biogenic amines was genetically investigated in indicated patients. Low 5‐HIAA was seen in 19.3%. Of these, 22.2% showed inborn errors of metabolism (mitochondrial disorders being the most frequent at 10.2% of low 5‐HIAA patients) and neurogenetic conditions. Other relatively frequent conditions were pontocerebellar hypoplasia (4.3%), Rett syndrome (4.3%), and among congenital nonetiologically determined conditions, epilepsy including epileptic encephalopathies (26.4%), leukodystrophies (6.8%), and neuropsychiatric disturbances (4.2%). Mutational analysis of the TPH2 gene, performed in five candidate patients, was negative. Although frequency of secondary alteration of 5‐HIAA was relatively high in patients with neurological disorders, this finding was more frequently associated with some neurometabolic disorders, epileptic encephalopathies, and neuropsychiatric disturbances. No inborn errors of TPH were found. Due to serotonin's neurotrophic role and to ameliorate symptoms, a supplementary treatment with 5‐hydroxytriptophan would seem advisable in these patients.
Metabolic investigations prevent liver transplantation in two young children with citrullinemia type I
Authors: de Groot Martijn J. , Cuppen Marcel , Eling Marc , Verheijen Frans W. , Rings Edmond H. H. M. , Reijngoud Dirk‐Jan , de Vries Maaike M. C. , van Spronsen Francjan J. 
Published: September 2010

AbstractAcute liver failure may be caused by a variety of disorders including inborn errors of metabolism. In those cases, rapid metabolic investigations and adequate treatment may avoid the need for liver transplantation. We report two patients who presented with acute liver failure and were referred to our center for liver transplantation work‐up. Urgent metabolic investigations revealed citrullinemia type I. Treatment for citrullinemia type I avoided the need for liver transplantation. Acute liver failure as a presentation of citrullinemia type I has not previously been reported in young children. Although acute liver failure has occasionally been described in other urea cycle disorders, these disorders may be underestimated as a cause. Timely diagnosis and treatment of these disorders may avoid liver transplantation and improve clinical outcome. Therefore, urea cycle disorders should be included in the differential diagnosis in young children presenting with acute liver failure.
Copper and Iron Determination with [N,N′‐Bis(salicylidene)‐2,2′‐dimethyl‐1,3‐propanediaminato] in Edible Oils Without Digestion
Authors: Baran Eda Köse , Yaşar Sema Bağdat 
Published: September 2010

AbstractA new method for the determination of copper(II) and iron(III) in liquid edible oils which does not require a digestion step was developed. The suggested method involves extraction of metals with [N,N′‐bis(salicylidene)‐2,2′‐dimethyl‐1,3‐propanediaminato] (LDM) followed by flame atomic absorption spectrometry measurement. As a first step, metal complexes of copper(II) and iron(III) ions with LDM were investigated spectrophotometrically. After the analytical properties and experimental conditions of the complexation had been determined, these findings were used to determine the extraction period as a second step. Experimental conditions were optimized using a central composite design. Optimum conditions for Cu(II) and Fe(III) extractions from oil were found: the ratios of the volume of Schiff base solution used to the mass of oil (VLDM/moil; mL g−1) were 0.76 and 1.19 mL g−1, the stirring times were 73 and 67 min, and the temperatures were 31 and 28 °C, respectively. The developed extraction and determination method was tested on certified reference materials; the recovery percentages were found to be 99.4 ± 2.8 and 100.2 ± 5.6 for Cu(II) and Fe(III), respectively. The suggested method was performed on real samples such as olive oil, sunflower oil, corn oil, canola oil and recovery values between 97.2–102.1 for Cu(II) and 94.5–98.6 for Fe(III) were determined. It was concluded that the developed method has some advantages over the common traditional method including rapidity, sensitivity, accuracy, reduced risk and cost.
Capturing the peer context: The paradox of progress⋆
Authors: Laursen Brett 
Published: September 2010

ABSTRACTAdolescents lead enormously complicated social lives. Many youth find it difficult to keep track of their own relationships with friends and romantic interests. For the investigator, the task is exponentially more complex because overlapping and interlocking relationships and networks must be disentangled, dissected, and diagrammed. This special issue contains some important new findings about peers, but it is equally noteworthy because it illustrates several significant methodological changes in the way we do business. New ways of thinking about peers and new ways of analyzing data about peer relationships promise to simplify many aspects of our research enterprise. Pictograms occupying every bit of space on laboratory walls are rapidly becoming a thing of the past. By the same token, however, these advances have revealed the limits of our assumptions and the inadequacies of our practices, particularly when it comes to the depth and frequency of our data collection efforts. This is the paradox of progress. In this essay I will summarize some of the methodological developments highlighted in this special section and I will describe some important implications that these improvements hold for research in the future.
PERFECT COLOURINGS OF ISONEMAL FABRICS BY THIN STRIPING
Authors: THOMAS R. S. D. 
Published: September 2010

AbstractPerfect colouring of isonemal fabrics by thin striping of warp and weft and the closely related topic of isonemal prefabrics that fall apart are reconsidered and their relation further explored. The catalogue of isonemal prefabrics that fall apart is extended to order 20 for those of even genus.
The Economic Role of Jumps and Recovery Rates in the Market for Corporate Default Risk
Authors: Schneider Paul , Sögner Leopold , Veža Tanja 
Published: September 2010

AbstractUsing an extensive cross section of U.S. corporate credit default swaps (CDSs), this paper offers an economic understanding of implied loss given default (LGD) and jumps in default risk. We formulate and underpin empirical stylized facts about CDS spreads, which are then reproduced in our affine intensity-based jump-diffusion model. Implied LGD is well identified, with obligors possessing substantial tangible assets expected to recover more. Sudden increases in the default risk of investment-grade obligors are higher relative to speculative grade. The probability of structural migration to default is low for investment-grade and heavily regulated obligors because investors fear distress rather through rare but devastating events.
Promoting multi-disciplinary and inter-disciplinary ageing research in the United Kingdom
Authors: HENNESSY CATHERINE HAGAN , WALKER ALAN 
Published: September 2010

ABSTRACTMulti-disciplinary and inter-disciplinary working has for long been advocated in gerontology, and sometimes contested. Although collaboration between disciplines is common practice in many areas of ageing research, much remains to be done to develop and support such work. Internationally, funding agencies, scientific associations and other stakeholders in ageing research are actively involved in establishing the methods and means to promote cross-disciplinary co-operation in the field. In the United Kingdom (UK) since the late 1990s, the statutory Research Councils with key interests in ageing and older people have been actively pursuing research programmes that feature multi-disciplinarity and inter-disciplinarity. The National Collaboration on Ageing Research (NCAR), a partnership among four of the Research Councils to stimulate cross-disciplinary collaboration, worked with scientists, funding bodies, and research users to develop approaches to multi- and inter-disciplinary research, and their work informed the New Dynamics of Ageing (NDA) Programme, a major cross-Research Council programme of multi-disciplinary research which spans the social, medical, biological and engineering sciences and the arts and humanities. Drawing on the authors' participation in these activities, this article reviews key developments in the promotion of multi-disciplinary science on ageing in the UK and highlights how this is being pursued in the NDA Programme.
Why Do Captured Archives Go Home? Restitution Achievements under the Russian Law
Authors: Grimsted Patricia Kennedy 
Published: September 2010

AbstractThe return of captured French archives—not art—ignited debate in the Russian Duma in the spring of 1994, leading to the passage of the 1998 Federal Law “On Cultural Valuables Displaced to the USSR as a Result of the Second World War and Located on the Territory of the Russian Federation.” Yet, a decade since the law was signed, there have been five cases of captured archives from the Second World War returned to Western European countries, as explained in the recent book, Returned from Russia. The aim of this article is to examine major factors involved in the restitution of archives from Russia, and why amid the politics of restitution the return of archives has been more successful than art.The article first successively examines the major factors involved, namely, foreign political pressure; the underlying support of international law, both in specific instruments and historical archival practice; the circumstances and Soviet aims of archival plunder; the present contrast with Soviet political ideology and alignments; the fact that Russian archivists were more willing to return their loot than museum directors; and that archival returns were easier to conform to the 1998 law, because the receiving countries were willing to offer the “compensation” Russian archivists were demanding. Country by country, first in Western Europe starting with France and now Austria and Greece, archives have been going home, but so far only a few symbolic files from Germany have been returned. A final section of the article briefly singles out the captured records from several other countries remaining in Moscow, including many Jewish records, even some representing Holocaust losses.
Chabad v. Russian Federation:A Case Study in the Use of American Courts to Recover Looted Cultural Property
Authors: Bazyler Michael J. , Gerber Seth M. 
Published: September 2010

AbstractDisplaced and nationalized cultural property remains hidden in the vast holdings of museums, libraries, and archives around the world. Some governments holding these “trophies” of war and conquest refuse to return such cultural treasures to their rightful owners even when their provenance has been identified. They assert that the collections were obtained through expropriation and nationalization, and that divestiture of a museum, library, or archive would jeopardize the existence of these institutions and cause societal discord.This article discusses the struggle of an orthodox Jewish organization to recover from the Russian Federation a collection of sacred, irreplaceable books and manuscripts seized in the aftermath of the Bolshevik Revolution and during World War II. The story of Agudas Chasidei Chabad's efforts to recover these core religious texts of its spiritual leaders has involved appeals by U.S. presidents, congress, and the U.S. Helsinki Commission, as well as lawsuits in the Soviet Union/Russia and United States.After prolonged litigation in the United States, a federal court of appeals in Washington DC ruled in 2008 that American courts have jurisdiction over Chabad's suit against the Russian Federation to recover its religious texts. This ruling may pave the way for the resolution of this dispute and also lead to the filing of other suits in American courts seeking to recover looted cultural property, even if that property is located outside U.S. borders.
The 1995 UNIDROIT Convention on Stolen or Illegally Exported Cultural Objects: The Role of International Arbitration
Authors: Sidorsky Emily 
Published: September 2010

SummaryGreat efforts have been made by representatives of a multitude of countries to rectify the situation currently confronting parties, whether they be private individuals or states, that seek the return of stolen or illegally exported cultural objects. The organization UNIDROIT has been at the forefront of that effort. In June of 1995, representatives of over seventy states met in Rome and adopted the UNIDROIT Convention on Stolen or Illegally Exported Cultural Objects. The UNIDROIT Convention will enter into force as it is ratified by individual states.The UNIDROIT Convention provides a claimant of a Contracting State with the option of using arbitration to settle its dispute. Until now, there has been little discussion of the advantages that international arbitration can bring to this domain. This article focuses on the benefits of international arbitration in facilitating the resolution of cultural property disputes. It presents an in-depth analysis of the text of the UNIDROIT Convention in the context of existing regulations in this area. It then examines three different approaches to international arbitration. These models serve to highlight the particular characteristics of this dispute resolution mechanism that make it ideally suited to cultural property disputes.
Restitution of Archaeological Artifacts: The Arab-Israeli Aspects
Authors: Einhorn Talia 
Published: September 2010

SummarySince the second half of the last century, public international law has been developing rules regulating the restitution of cultural objects removed from occupied territories during armed conflict. Today it is generally recognized that customary international law forbids pillage. The Protocol to the 1954 Hague Convention for the Protection of Cultural Property in the Event of Armed Conflict further mandates that artifacts removed from an occupied territory must be returned to the competent authorities of that territory at the close of hostilities. The Arab-Israeli case highlights the problematic side of this solution. Following the Six Day War in 1967, the Sinai Peninsula, the Golan Heights, the Gaza strip and the territory known as the “West Bank” came under Israeli control. Israeli archaeologists carried out numerous excavations, and discovered artifacts of special importance to Jewish cultural heritage. It is regrettable that, as a result of the peace treaty with Egypt, these artifacts can no longer be exhibited and appreciated at the Israel Museum in Jerusalem, but had to be delivered to Egypt, where they now face an uncertain future. A similar fate may befall the artifacts excavated in the Golan Heights. The Palestinian claim for restitution cannot be based on the Protocol. The Problem is nevertheless the same in all cases; if the artifacts are to be preserved, properly appreciated and made available for purposes of study and research, it may be more appropriate to distribute them among the states by way of compromise and agreement, that will seek to enhance their cultural significance, rather than use the arbitrary sole criterion of the place of discovery.
Transcribing the Beneventan chant
Authors: Peattie Matthew G. 
Published: September 2010

ABSTRACTThe Beneventan Mass Propers are preserved in sources that are notated, for the most part, in campo aperto – without staff lines or clefs to indicate the pitch or placement of the semitone. Despite the absence of pitch-specific notation, it is possible to discern a great deal about the pitch of the Beneventan chant and to propose verifiable transcriptions. This article provides a systematic overview of the pitch placement of the Beneventan repertory through a study of the formulaic structure of the chant and through a comparative examination of the small number of exemplars of Beneventan chant notated on a staff line.
Reptile: representative tiling for short read error correction
Authors: Yang Xiao , Dorman Karin S. , Aluru Srinivas 
Published: September 2010

AbstractMotivation: Error correction is critical to the success of next-generation sequencing applications, such as resequencing and de novo genome sequencing. It is especially important for high-throughput short-read sequencing, where reads are much shorter and more abundant, and errors more frequent than in traditional Sanger sequencing. Processing massive numbers of short reads with existing error correction methods is both compute and memory intensive, yet the results are far from satisfactory when applied to real datasets.Results: We present a novel approach, termed Reptile, for error correction in short-read data from next-generation sequencing. Reptile works with the spectrum of k-mers from the input reads, and corrects errors by simultaneously examining: (i) Hamming distance-based correction possibilities for potentially erroneous k-mers; and (ii) neighboring k-mers from the same read for correct contextual information. By not needing to store input data, Reptile has the favorable property that it can handle data that does not fit in main memory. In addition to sequence data, Reptile can make use of available quality score information. Our experiments show that Reptile outperforms previous methods in the percentage of errors removed from the data and the accuracy in true base assignment. In addition, a significant reduction in run time and memory usage have been achieved compared with previous methods, making it more practical for short-read error correction when sampling larger genomes.Availability: Reptile is implemented in C++ and is available through the link: http://aluru-sun.ece.iastate.edu/doku.php?id=softwareContact: aluru@iastate.edu
Semi-supervised recursively partitioned mixture models for identifying cancer subtypes
Authors: Koestler Devin C. , Marsit Carmen J. , Christensen Brock C. , Karagas Margaret R. , Bueno Raphael , Sugarbaker David J. , Kelsey Karl T. , Houseman E. Andres 
Published: September 2010

AbstractMotivation: Patients with identical cancer diagnoses often progress differently. The disparity we see in disease progression and treatment response can be attributed to the idea that two histologically similar cancers may be completely different diseases on the molecular level. Methods for identifying cancer subtypes associated with patient survival have the capacity to be powerful instruments for understanding the biochemical processes that underlie disease progression as well as providing an initial step toward more personalized therapy for cancer patients. We propose a method called semi-supervised recursively partitioned mixture models (SS-RPMM) that utilizes array-based genetic and patient-level clinical data for finding cancer subtypes that are associated with patient survival.Results: In the proposed SS-RPMM, cancer subtypes are identified using a selected subset of genes that are associated with survival time. Since survival information is used in the gene selection step, this method is semi-supervised. Unlike other semi-supervised clustering classification methods, SS-RPMM does not require specification of the number of cancer subtypes, which is often unknown. In a simulation study, our proposed method compared favorably with other competing semi-supervised methods, including: semi-supervised clustering and supervised principal components analysis. Furthermore, an analysis of mesothelioma cancer data using SS-RPMM, revealed at least two distinct methylation profiles that are informative for survival.Availability: The analyses implemented in this article were carried out using R (http://www.r.project.org/).Contact: devin_koestler@brown.edu; e_andres_houseman@brown.eduSupplementary information: Supplementary data are available at Bioinformatics online.