bluuebunny/crossref_metadata_2025_split huggingface dataset:
INVESTMENT POTENTIAL OF CITIES IN THE CONDITIONS OF WAR
Authors: Denysenko Nataliia , Bondarenko Oleksandr 
Published: April 2024

The investment potential of Ukrainian cities during the war is analysed in this article. It defines the concept of 'investment potential of a city' and analyses its key components and interrelationships, including economic stability, infrastructure and logistics, market potential, level of innovation, education, and labour force. Research has shown that the investment potential of a city is closely linked to its level of economic stability. Therefore, effective risk reduction and sound financial management are crucial in attracting long-term investments. It has been revealed that transport connections, communication networks, and other logistical aspects contribute to the growth of a city's investment potential. However, the war has significantly impacted urban infrastructure and logistics in Ukraine, creating serious challenges for the functioning and development of cities. The military situation in Ukraine has had a significant impact on the economic environment and business infrastructure, challenging the market potential of cities. The level of innovation in cities is affected by the situation of war, which brings many challenges and limitations. However, innovation can be an important factor in post-conflict adaptation and reconstruction. Challenges that can affect a city's investment potential include the impact of military conflict on education and the workforce. Therefore, it is crucial to focus on restoring and supporting educational initiatives, creating conditions to attract the best talent, and stimulating innovation in education and human resource development to overcome the challenges posed by war. The investment potential of cities is a multi-faceted indicator that reflects economic, socio-cultural and technological dynamics and helps to make informed decisions about investment and urban infrastructure development.
CHESS AS A SUBJECT OF SOCIAL AND SPIRITUAL CREATIVITY OF HUMANITY: PHILOSOPHICAL REFLECTION
Authors: Stavroyany Serhii , Spiridonov Mykola 
Published: April 2024

The research highlights the key paradigms of social and spiritual background of chess; the profound philosophical insight into chess as a distinct social and cultural phenomenon has been provided. Chess was proved to be the result of collective creativity of many generations and to be initially endowed with ritual, religious and educational functions. A set of rules and core values of chess suggest that the game pinpointed the existing social relations, applying military strategies and tactics, and embraced the influence of religious, cultural and gender factors; primarily it represented the structure of the Indian army, subsequently encompassing the European reality and principles of social hierarchy: the sanctity and supremacy of the monarchy and class system. The alteration of social relations, military strategy and gender roles determined the paradigm shift in chess as well (considering a showcase of the Renaissance Western-European innovations).
An Investigation into the Relationship between Transformational Leadership Style and Organizational Commitment in a College of Administration and Economics: An Empirical Research
Authors: Fakhrulddin Mahmood* Maryam 
Published: April 2024

The current research aims to demonstrate the relationship and impact between transformational leadership and its dimensions (Idealized Influence Behaviour, Idealized Influence Attributed, Intellectual Stimulation, Inspiring Motivation, and Individual Consideration) on organizational commitment and its dimensions (continuous organizational commitment, emotional organizational commitment, and normative organizational commitment) at the College of Administration and Economics. Descriptive-analytical approach used to achieve the core object of the research. The research adopted the questionnaire as the core tool for this purpose. A research sample included various administrative levels (director, chief inspector, supervisor, and assistant supervisor). The questionnaire distributed randomly, and 70 valid questionnaires collected for statistical analysis. The research adapted a set of statistical methods such as arithmetic mean, coefficient of variation, standard deviation, and simple regression coefficient by the statistical program (SPSS V26) to analyze data and test hypotheses. The research reached a set of essential results, the most important of which was that transformational leadership is the main factor for building an organization's culture to achieve growth and success and motivate individuals.

Paper type: Research paper
Estimation of the Regression Model Using M-Estimation Method and Artificial Neural Networks in the Presence of Outliers
Authors: Talib Jawad Hussein , Abdul-Ridha Saleh Rabab 
Published: April 2024

This study aimed to predict using regression models in the presence of outliers in the study data. The research delved into outliers, their detection, and model estimation through robust methods, represented by the M estimator and multilayer artificial neural networks. A comparison between these methods was conducted, and they were applied to real data representing a survey of private-sector power generators for 2021. Model evaluation was performed using Mean Squared Error (MSE) and the determination coefficient. The results indicated that the M-estimator with the Huber function outperformed its counterpart with the Tukey function. The best-performing architecture for the artificial neural network was ML-FF (5, 16, 32, 46, 128, 1) with the relu activation function. This network effectively handled extreme values and exhibited strong predictive capabilities. The choice of activation function and the number of hidden layers significantly impacted the neural network's performance, with the results showing the superiority of this artificial neural network over the robust estimators.

Paper type Research paper
PERENCANAAN PENGEMBANGAN ASET FASILITAS HUTAN KOTA PATRIOT BINA BANGSA BEKASI BERDASARKAN PLACEMAKING
Authors: Melati Realita  , Angestiwi Tiafahmi 
Published: April 2024

Hutan Kota Bekasi merupakan salah satu Ruang Terbuka Hijau (RTH) dengan luas 42.673 m2. Di Hutan Kota Patriot Bina Bangsa Bekasi, aset fasilitas yang tersedia berkualitas buruk. Pengembangan aset fasilitas dilaksanakan berdasarkan konsep Placemaking berdasarkan kriteria Access and Linkages, Comfort and Image, Uses and Activities, dan Sociability. Tujuan proyek ini adalah untuk menghasilkan rencana pengembangan aset fasilitas dan besarnya estimasi biaya. Metode analisis menggunakan analisis deskriptif dengan pendekatan kualitatif dan kuantitatif. Teknik pengumpulan data meliputi observasi dan wawancara. Proyek ini menghasilkan desain berdasarkan kriteria Access and Linkages meliputi jalur pejalan kaki dengan luas 1040 m2 dan area parkir dengan luas 587,08 m2. Rencana Comfort and Image dengan menyediakan mushola 49,5 m2, toilet 71,58 m2, bangku taman 26 unit, tempat sampah 26 unit, lampu taman 52 unit, pos jaga 4 m2 dan CCTV 4 unit. Kriteria Uses and Activities direncanakan ruang bermain anak dengan 3 unit fasilitas jungkat-jungkit, 2 unit ayunan, dan 1 set taman bermain anak. Ruang olahraga direncanakan dengan fasilitas jogging track 500 m2, outdoor fitness, dan lapangan basket 420 m2. Dan ruang rekreasi direncanakan fasilitas paintball berukuran 50 x 20 m. Sedangkan sebagai kriteria Sociability direncanakan fasilitas ampiteater dengan luas 225 m2. Estimasi biaya pembongkaran, pembangunan, dan biaya pengadaan jika terealisasi pada tahun 2023 adalah Rp5.538.640.885.
Kata kunci: Aset Hutan Kota, Kualitas RTH, Placemaking, Perencanaan, Pengembangan
Balance recovery for lower limb exoskeleton in standing posture based on orbit energy analysis
Authors: Li Mengze , Zhang Bi , Liu Ligang , Tan Xiaowei , Li Ning , Zhao Xingang 
Published: April 2024

Introduction: The need for effective balance control in lower limb rehabilitation exoskeletons is critical for ensuring stability and safety during rehabilitation training. Current research into specialized balance recovery strategies is limited, highlighting a gap in biomechanics-inspired control methods.Methods: We introduce a new metric called “Orbit Energy” (OE), which assesses the balance state of the human-exoskeleton system based on the dynamics of the overall center of mass. Our control framework utilizes OE to choose appropriate balance recovery strategies, including torque controls at the ankle and hip joints.Results: The efficacy of our control algorithm was confirmed through Matlab Simulink simulations, which analyzed the recovery of balance under various disturbance forces and conditions. Further validation came from physical experiments with human subjects wearing the exoskeleton, where a significant reduction in muscle activation was observed during balance maintenance under external disturbances.Discussion: Our findings underscore the potential of biomechanics-inspired metrics like OE in enhancing exoskeleton functionality for rehabilitation purposes. The introduction of such metrics could lead to more targeted and effective balance recovery strategies, ultimately improving the safety and stability of exoskeleton use in rehabilitation settings.
Interactions between circulating inflammatory factors and autism spectrum disorder: a bidirectional Mendelian randomization study in European population
Authors: Long Junzi , Dang Hui , Su Wenlong , Moneruzzaman Md. , Zhang Hao 
Published: April 2024

BackgroundExtensive observational studies have reported an association between inflammatory factors and autism spectrum disorder (ASD), but their causal relationships remain unclear. This study aims to offer deeper insight into causal relationships between circulating inflammatory factors and ASD.MethodsTwo-sample bidirectional Mendelian randomization (MR) analysis method was used in this study. The genetic variation of 91 circulating inflammatory factors was obtained from the genome-wide association study (GWAS) database of European ancestry. The germline GWAS summary data for ASD were also obtained (18,381 ASD cases and 27,969 controls). Single nucleotide polymorphisms robustly associated with the 91 inflammatory factors were used as instrumental variables. The random-effects inverse-variance weighted method was used as the primary analysis, and the Bonferroni correction for multiple comparisons was applied. Sensitivity tests were carried out to assess the validity of the causal relationship.ResultsThe forward MR analysis results suggest that levels of sulfotransferase 1A1, natural killer cell receptor 2B4, T-cell surface glycoprotein CD5, Fms-related tyrosine kinase 3 ligand, and tumor necrosis factor-related apoptosis-inducing ligand are positively associated with the occurrence of ASD, while levels of interleukin-7, interleukin-2 receptor subunit beta, and interleukin-2 are inversely associated with the occurrence of ASD. In addition, matrix metalloproteinase-10, caspase 8, tumor necrosis factor-related activation-induced cytokine, and C-C motif chemokine 19 were considered downstream consequences of ASD.ConclusionThis MR study identified additional inflammatory factors in patients with ASD relative to previous studies, and raised a possibility of ASD-caused immune abnormalities. These identified inflammatory factors may be potential biomarkers of immunologic dysfunction in ASD.
Relationship between age and remimazolam dose required for inducing loss of consciousness in older surgical patients
Authors: Song Jin-Chao , Wang Xiao-xi , Fu Xiang , Chen Wei , Tang Shu-heng , Deng Fang , Yang Hua , Liu Wen 
Published: April 2024

BackgroundRemimazolam is a new ultra-short-acting benzodiazepine for procedural sedation and general anaesthesia, characterised by rapid onset of action, quick recovery, and organ-independent metabolism. Older patients tend to sustain more treatment-emergent adverse events (TEAEs) and worse perioperative prognoses after receiving remimazolam. However, few studies have investigated the appropriate dose of remimazolam for loss of consciousness (LOC) in geriatric patients. We designed this study to provide evidence for dose references and elucidate the relationship between age and remimazolam requirement for inducing LOC during anaesthesia induction.MethodsExactly 120 patients scheduled for general surgery under general anaesthesia were included and divided into two groups: Group A (60 patients, 18–64 years) and Group B (60 patients, ≥ 65 years). LOC, defined as a Modified Observer’s Assessment of Alertness and Sedation score at 1 had been reached, emerged after all participants received a continuous infusion of remimazolam at a rate of 0.05 mg/kg/min.ResultsThe remimazolam required for inducing LOC was 0.26 and 0.19 mg/kg in groups A and B, respectively, and the remimazolam dose in group B decreased by 26.9% compared to group A. According to the bivariate linear correlation analysis, remimazolam requirement was negatively correlated with age. Multivariable linear regression models and further adjustments for potential impact factors indicated that age was an independent factor for the remimazolam dose required for LOC.ConclusionThis study demonstrated that age was significantly and independently correlated with the remimazolam requirement for inducing LOC. To obtain haemodynamic stability during the induction of general anaesthesia, appropriately reducing the remimazolam dose is recommended for geriatric patients.
Topographic organization across foveal visual areas in macaques
Authors: Li Hangqi , Hu Danling , Tanigawa Hisashi , Takahata Toru 
Published: April 2024

IntroductionWhile the fovea on the retina covers only a small region of the visual field, a significant portion of the visual cortex is dedicated to processing information from the fovea being a critical center for object recognition, motion control, and visually guided attention. Despite its importance, prior functional imaging studies in awake monkeys often focused on the parafoveal visual field, potentially leading to inaccuracies in understanding the brain structure underlying function.MethodsIn this study, our aim is to unveil the neuronal connectivity and topography in the foveal visual cortex in comparison to the parafoveal visual cortex. Using four different types of retrograde tracers, we selectively injected them into the striate cortex (V1) or V4, encompassing the regions between the fovea and parafovea.ResultsV1 and V4 exhibited intense mutual connectivity in the foveal visual field, in contrast to the parafoveal visual field, possibly due to the absence of V3 in the foveal visual field. While previous live brain imaging studies failed to reveal retinotopy in the foveal visual fields, our results indicate that the foveal visual fields have continuous topographic connectivity across V1 through V4, as well as the parafoveal visual fields. Although a simple extension of the retinotopic isoeccentricity maps from V1 to V4 has been suggested from previous fMRI studies, our study demonstrated that V3 and V4 possess gradually smaller topographic maps compared to V1 and V2. Feedback projections to foveal V1 primarily originate from the infragranular layers of foveal V2 and V4, while feedforward projections to foveal V4 arise from both supragranular and infragranular layers of foveal V1 and V2, consistent with previous findings in the parafoveal visual fields.DiscussionThis study provides valuable insights into the connectivity of the foveal visual cortex, which was ambiguous in previous imaging studies.
The impact of tumor budding and single-cell invasion on survival in patients with stage III/IV locally advanced oral squamous cell carcinoma- results from a prospective cohort study
Authors: Hakim Samer G. , Alsharif Ubai , Falougy Mohamed , Tharun Lars , Rades Dirk , Jensen Justus 
Published: April 2024

IntroductionTumor budding (TB) refers to the presence of small clusters of tumor cells at the invasive front of a malignant tumor. Single tumor cell invasion (SCI) is an extreme variant of TB, in which individual loose tumor cells are present at the invasive front. Both TB and SCI are important histomorphologic risk factors postulated to indicate loss of cellular cohesion. In this study, we investigated the influence of TB and SCI on different survival outcomes in patients with locally advanced oral squamous cell carcinoma (OSCC).MethodsWe included 129 patients with locally advanced OSCC (pT3-4) from a single-center, prospectively maintained cohort. We examined the association of TB and SCI with the presence of occult lymph node metastasis using a logistic regression model. Survival probabilities were estimated using the Kaplan-Meier method and cumulative incidence functions. The association of TB and SCI on overall survival (OS), oral cancer-specific survival (OCSS), and local recurrence-free survival (LRFS) was investigated using Cox’s proportional hazards regression models. ResultsTB was detected in 98 (76%) of the tumors, while SCI was observed in 66 (51%) patients. There was a significant association between TB and the occurrence of occult lymph node metastasis (OR=3.33, CI: 1.21-10.0). On multivariate analysis, TB had no detectable impact on survival outcomes. However, SCI showed a higher risk for local recurrence (Hazards ratio (HR): 3.33, CI: 1.19 – 9.27). DiscussionThis study demonstrates that TB and SCI in locally advanced OSCC function as an independent risk factor for occult lymph node metastases, as well as local recurrences. Both histomorphologic risk factors could serve as an additional parameter for stratifying therapy and escalating multimodal treatment approaches.
Anti-rheumatoid arthritis effects of traditional Chinese medicine Fufang Xiaohuoluo pill on collagen-induced arthritis rats and MH7A cells
Authors: Yin Qiong , Huang Qian , Zhang Hantao , Zhang Xiaodi , Fan Chunlan , Wang Hongping 
Published: April 2024

BackgroundFufang Xiaohuoluo pill (FFXHL) is a commonly used prescription in clinical practice for treating rheumatoid arthritis in China, yet its specific mechanism remains unclear. This study aims to elucidate the pharmacological mechanisms of FFXHL using both in vivo and in vitro experiments.MethodsThe collagen-induced arthritis (CIA) rat model was established to evaluate FFXHL’s therapeutic impact. Parameters that include paw swelling, arthritis scores, and inflammatory markers were examined to assess the anti-inflammatory and analgesic effects of FFXHL. Human fibroblast-like synoviocytes (MH7A cells) is activated by tumour necrosis factor-alpha (TNF-α) were used to explore the anti-inflammatory mechanism on FFXHL.ResultsOur findings indicate that FFXHL effectively reduced paw swelling, joint pain, arthritis scores, and synovial pannus hyperplasia. It also lowered serum levels of TNF-α, interleukin-1β (IL1β), and interleukin-6 (IL-6). Immunohistochemical analysis revealed decreased expression of nuclear factor-kappa B (NF-κB) p65 in FFXHL-treated CIA rat joints. In vitro experiments demonstrated FFXHL’s ability to decrease protein secretion of IL-1β and IL-6, suppress mRNA expression of matrix metalloproteinases (MMP) −3, −9, and −13, reduce reactive oxygen species (ROS) levels, and inhibit NF-κB p65 translocation in TNF-α stimulated MH7A cells. FFXHL also suppressed protein levels of extracellular signal-regulated kinase (ERK), c-Jun Nterminal kinase (JNK), p38 MAP kinase (p38), protein kinase B (Akt), p65, inhibitor of kappa B kinase α/β (IKKα/β), Toll-like receptor 4 (TLR4), and myeloid differentiation primary response 88 (MyD88) induced by TNF-α in MH7A cells.ConclusionThe findings imply that FFXHL exhibits significant anti-inflammatory and antiarthritic effects in both CIA rat models and TNF-α-induced MH7A cells. The potential mechanism involves the inactivation of TLR4/MyD88, mitogen-activated protein kinases (MAPKs), NF-κB, and Akt pathways by FFXHL.
Genome-wide analysis of UDP-glycosyltransferases family and identification of UGT genes involved in drought stress of Platycodon grandiflorus
Authors: Chen Bowen , Wang Xinrui , Yu Hanwen , Dong Nan , Li Jing , Chang Xiangwei , Wang Jutao , Jiang Chao , Liu Juan , Chi Xiulian , Zha Liangping , Gui Shuangying 
Published: April 2024

IntroductionThe uridine diphosphate (UDP)-glycosyltransferase (UGT) family is the largest glycosyltransferase family, which is involved in the biosynthesis of natural plant products and response to abiotic stress. UGT has been studied in many medicinal plants, but there are few reports on Platycodon grandiflorus. This study is devoted to genome-wide analysis of UGT family and identification of UGT genes involved in drought stress of Platycodon grandiflorus (PgUGTs).MethodsThe genome data of Platycodon grandiflorus was used for genome-wide identification of PgUGTs, online website and bioinformatics analysis software was used to conduct bioinformatics analysis of PgUGT genes and the genes highly responsive to drought stress were screened out by qRT-PCR, these genes were cloned and conducted bioinformatics analysis.ResultsA total of 75 PgUGT genes were identified in P.grandiflorus genome and clustered into 14 subgroups. The PgUGTs were distributed on nine chromosomes, containing multiple cis-acting elements and 22 pairs of duplicate genes were identified. Protein-protein interaction analysis was performed to predict the interaction between PgUGT proteins. Additionally, six genes were upregulated after 3d under drought stress and three genes (PGrchr09G0563, PGrchr06G0523, PGrchr06G1266) responded significantly to drought stress, as confirmed by qRT-PCR. This was especially true for PGrchr06G1266, the expression of which increased 16.21-fold after 3d of treatment. We cloned and conducted bioinformatics analysis of three candidate genes, both of which contained conserved motifs and several cis-acting elements related to stress response, PGrchr06G1266 contained the most elements.DiscussionPgGT1 was confirmed to catalyze the C-3 position of platycodin D and only eight amino acids showed differences between gene PGr008G1527 and PgGT1, which means PGr008G1527 may be able to catalyze the C-3 position of platycodin D in the same manner as PgGT1. Seven genes were highly expressed in the roots, stems, and leaves, these genes may play important roles in the development of the roots, stems, and leaves of P. grandiflorus. Three genes were highly responsive to drought stress, among which the expression of PGrchr06G1266 was increased 16.21-fold after 3d of drought stress treatment, indicating that PGrchr06G1266 plays an important role in drought stress tolerance. To summarize, this study laied the foundation to better understand the molecular bases of responses to drought stress and the biosynthesis of platycodin.