bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosis of Gleason score 8 prostatic adenocarcinoma in needle biopsies: a nationwide population-based study
Authors: Egevad Lars , Micoli Chiara , Delahunt Brett , Samaratunga Hemamali , Orrason Andri Wilberg , Garmo Hans , Stattin Pär , Eklund Martin 
Published: April 2024

AbstractA 5-tier grouping of Gleason scores has recently been proposed. Studies have indicated prognostic heterogeneity within these groups. We assessed prostate cancer-specific mortality (PCSM) and all-cause mortality (ACM) for men diagnosed with Gleason score 3 + 5 = 8, 4 + 4 = 8 and 5 + 3 = 8 acinar adenocarcinoma on needle biopsy in a population-based national cohort. The Prostate Cancer data Base Sweden 5.0 was used for survival analysis with PCSM and ACM at 5 and 10 years as endpoints. Multivariable Cox regression models controlling for socioeconomic factors, stage and primary treatment type were used for PCSM and ACM. Among 199,620 men reported with prostate cancer in 2000–2020, 172,112 were diagnosed on needle biopsy. In 18,281 (11%), there was a Gleason score of 8 in needle biopsies, including a Gleason score of 3 + 5, 4 + 4 and 5 + 3 in 11%, 86% and 2.3%, respectively. The primary treatment was androgen deprivation therapy (55%), deferred treatment (8%), radical prostatectomy (16%) or radical radiotherapy (21%). PCSM in men with Gleason scores of 3 + 5, 4 + 4 and 5 + 3 at 5 years of follow-up was 0.10 (95% CI 0.09–0.12), 0.22 (0.22–0.23) and 0.32 (0.27–0.36), respectively, and at 10 years 0.19 (0.17–0.22), 0.34 (0.33–0.35) and 0.44 (0.39–0.49), respectively. There was a significantly higher PCSM after 5 and 10 years in men with Gleason score 5 + 3 cancers than in those with 4 + 4 and in Gleason score 4 + 4 cancers than in those with 3 + 5. Grouping of Gleason scores will eliminate the prognostic granularity of Gleason scoring, thus diminishing the prognostic significance of this proposed grading system.
Posterior reversible encephalopathy syndrome associated with antibiotic therapy: a case report and systematic review
Authors: Barba Lorenzo , Carrubba Carmelo , Spindler Kai , Weise Christopher M. , Sachs Torben , Foschi Matteo , D’Anna Lucio , Sehm Bernhard , Ibe Richard , Elolf Erck , Strauss Christian , Otto Markus , Mensch Alexander , Abu-Rumeileh Samir 
Published: April 2024

AbstractPosterior reversible encephalopathy syndrome (PRES) is an acute neurological condition associated with different etiologies, including antibiotic therapy. To date, most data regarding antibiotic-related PRES are limited to case reports and small case series. Here, we report a novel case description and provide a systematic review of the clinico-radiological characteristics and prognosis of available cases of PRES associated with antibiotic therapy. We performed a systematic literature search in PubMed and Scopus from inception to 10 January 2024, following PRISMA guidelines and a predefined protocol. The database search yielded 12 subjects (including our case). We described the case of a 55-year-old female patient with PRES occurring one day after administration of metronidazole and showing elevated serum neurofilament light chain protein levels and favorable outcome. In our systematic review, antibiotic-associated PRES was more frequent in female patients (83.3%). Metronidazole and fluoroquinolones were the most reported antibiotics (33.3% each). Clinical and radiological features were comparable to those of PRES due to other causes. Regarding the prognosis, about one third of the cases were admitted to the intensive care unit, but almost all subjects (90.0%) had a complete or almost complete clinical and radiological recovery after prompt cessation of the causative drug. Antibiotic-associated PRES appears to share most of the characteristics of classic PRES. Given the overall good prognosis of the disease, it is important to promptly diagnose antibiotic-associated PRES and discontinue the causative drug.
Cascadic degradation of selected polyolefin grades in a simulated closed-loop recycling process
Authors: Akhras Mohamad Hassan , Langwieser Johanna , Czaker Sandra , Felgel-Farnholz Alexander , Fischer Joerg 
Published: April 2024

AbstractReintroducing recycled plastics into production processes can lead to irreversible degradation and changes in their properties, thereby limiting their recycling potential to a finite number of loops. This study investigates the impact of process-induced degradation resulting from multiple reprocessing cycles on specific material properties and aims to establish structure–property relationships. Four different polyolefins, including two polypropylenes, high-density polyethylene, and low-density polyethylene, were selected for the study. The materials underwent extrusion, pelletizing, injection molding, and milling before being reintroduced into the reprocessing cycle. This sequence of processing steps was repeated six times on each material. Various characterization techniques, including high-temperature gel permeation chromatography, melt mass flow rate, parallel-plate rheology, differential scanning calorimetry, gas chromatography–mass spectrometry, and optical defect control system, were performed to evaluate the molecular structure, rheological behavior, thermal stability, and the resulting contaminants and defects after each reprocessing step. The reprocessing of polypropylene resulted in a gradual decrease in the average molecular weights accompanied by a shift to lower viscosities and higher melt mass flow rates, whereas the polyethylene grades showed the opposite trend with a less pronounced effect in high-density polyethylene. The volatile organic compounds rose in polypropylene and sank in polyethylene after reprocessing. Additionally, all four materials exhibited an increase in degradation-related defects based on optical defect analysis.
Graphical abstract
Disentangled Variational Autoencoder for Social Recommendation
Authors: Zhang Yongshuai , Huang Jiajin , Yang Jian 
Published: April 2024

AbstractSocial recommendation aims to improve the recommendation performance by learning user interest and social representations from users’ interaction records and social relations. Intuitively, these learned representations entangle user interest factors with social factors because users’ interaction behaviors and social relations affect each other. A high-quality recommender system should provide items to a user according to his/her interest factors. However, most existing social recommendation models aggregate the two kinds of representations indiscriminately, and this kind of aggregation limits their recommendation performance. In this paper, we develop a model called Disentangled Variational autoencoder for Social Recommendation (DVSR) to disentangle interest and social factors from the two kinds of user representations. Firstly, we perform a preliminary analysis of the entangled information on three popular social recommendation datasets. Then, we present the model architecture of DVSR, which is based on the Variational AutoEncoder (VAE) framework. Besides the traditional method of training VAE, we also use contrastive estimation to penalize the mutual information between interest and social factors. Extensive experiments are conducted on three benchmark datasets to evaluate the effectiveness of our model.
Examining characteristics and sampling methods of phosphor dynamics in lowland catchments
Authors: Risch Henrike T. , Wagner Paul D. , Hörmann Georg , Fohrer Nicola 
Published: April 2024

AbstractDespite over two decades since the EU Water Framework Directive have passed, achieving the desired water quality in German surface waters remains challenging, regardless of efforts to reduce phosphorus inputs and associated environmental impacts. This study aims at analyzing the characteristics governing the concentrations of four key water quality parameters (total phosphorus, orthophosphate, particulate phosphate, and suspended solids) in two lowland catchments: the 50 km2 catchment of the Kielstau, Germany, and its 7 km2 tributary, the Moorau, which are dominated by agricultural land use. To this end, different sampling methods, particularly high-resolution precipitation event-based sampling and daily mixed samples, are conducted and evaluated, and their effectiveness is compared. The identification of sources and characteristics that affect phosphorus and suspended sediment dynamics, both in general and specifically during heavy precipitation events, is one focus of the study. Over a 15-year period, increasing concentrations of these parameters were observed in daily mixed samples, exhibiting distinct seasonal patterns—higher in summer and lower in winter—consistent with lowland catchment behavior. Particularly during heavy precipitation events, the smaller catchment exhibits a more complex and less predictable response to chemical concentrations compared with the dilution effect observed in the larger catchment. The results underline the complexity of phosphorus dynamics in small catchments and emphasize the importance of event-based sampling for capturing short-term concentration peaks for all four parameters, particularly beneficial regarding measuring suspended solids. While daily mixed samples capture average phosphorus concentrations, event-based sampling is crucial for detecting short-term spikes, providing a more comprehensive understanding of phosphorus dynamics.
The development of intent-based trust in moral testimony
Authors: Margoni Francesco , Nava Elena 
Published: April 2024

AbstractResearch has shown that by age 5–6 years, children fully integrate information about agents’ mental states into their verbal moral judgments: When asked to say whether an agent is morally good or bad, they rely on the agent’s intentions more than on its action’s outcomes. Research has also shown that from an early age, children use a plethora of social and moral cues when deciding whom to trust in learning and testimony situations. Here, for the first time, we asked if and how children’s trust in informants who relay information about the moral character of a novel agent is influenced by the valence of the intentions underlying the informants’ prior actions. Italian children aged 6 to 10 years (n = 219, 112 female) were first presented with two puppets and asked to judge them. One puppet accidentally caused harm (neutral intention, negative outcome), the other attempted but failed to do so (negative intention, neutral outcome). Next, the puppets gave contrasting testimonies about whether a novel agent was good or bad. Findings revealed that the tendency to trust the assessment of the well-intentioned puppet concerning the novel agent emerged at age 8, whereas younger children simply showed to believe that the novel agent was good, regardless of the testimonies they received. These results suggest that despite the ability to generate intent-based moral judgments emerges at age 5–6, the tendency to rely on intentions underlying past actions of informants when assessing informants’ testimonies about the moral character of a third party undergoes significant change in childhood.
Integrative Analysis of Site-Specific Parameters with Nuisance Parameters on the Common Support
Authors: Ho Ho Yi Alexis , Xu Shuoxun , Guo Xinzhou 
Published: April 2024

AbstractHigh-throughput technologies in bioscience have pushed us into an era with high dimensionality. Swamped by thousands of predictors, detecting the valuable signal from the noise in clinical studies becomes challenging. As a common strategy, integrative analysis utilizing similarities across multiple studies might help lift the curse of dimensionality and enhance statistical power. However, due to the growing concern about individual data privacy, data-sharing constraints are often imposed in integrative analysis. These might lead to results inequivalent to ones without sharing constraints and reduce statistical power in integrative analyses. In this paper, built on Abess, we propose an integrative analysis method to estimate the site-specific parameters in the presence of high dimensional nuisance parameters in multi-site studies. Implemented with a carefully designed $$L_{2,0}$$

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penalization on nuisance parameters, the proposed method satisfies both the DataSHIELD constraint, which only allows the transmission of summary statistics from sites, and the equivalence property that the solution is exactly the same as the solution merging all datasets into one on a single location. Assuming the nuisance parameters share a common support, the proposed method has support recovery and selection consistency with high probability and exhibits improved estimation accuracy on the site-specific parameters and low computational cost in numerical experiments. We demonstrate the merit of the proposed method by investigating the relationship between the CD8 T cell count and the treatment effect of zidovudine-incorporated therapy in the AIDS Clinical Trials Group Study 175.
Sustainable coffee: A review of the diverse initiatives and governance dimensions of global coffee supply chains
Authors: Wright Dale R. , Bekessy Sarah A. , Lentini Pia E. , Garrard Georgia E. , Gordon Ascelin , Rodewald Amanda D. , Bennett Ruth E. , Selinske Matthew J. 
Published: April 2024

AbstractWith a global footprint of 10 million hectares across 12.5 million farms, coffee is among the world’s most traded commodities. The coffee industry has launched a variety of initiatives designed to reduce coffee’s contribution to climate change and biodiversity loss and enhance the socio-economic conditions of coffee producers. We systematically reviewed the literature on the sustainability and governance of coffee production and developed a typology of eleven sustainability initiatives. Our review shows that coffee sustainability research has focused primarily on the economic outcomes of certification schemes. The typology expands our knowledge of novel sustainability initiatives being led by coffee farming communities themselves, allowing for an improved consideration of power dynamics in sustainability governance. Sustainability initiatives governed by local actors can improve sustainability outcomes by empowering local decision makers to assess direct risks and benefits of sustainable practices to the local environment, economy, and culture.
Case report. Scrotaal maligne mesothelioom
Authors: Straten Frederika J. , Alberts Arnout R. , Zuiverloon Tahlita C. M. , van den Broeke Pieter J. 
Published: April 2024

SamenvattingHet scrotaal maligne mesothelioom is een agressieve tumor die uitgaat van de tunica vaginalis. Het zeldzame karakter en de atypische presentatie maken dat deze tumor vaak pas bij de histologische beoordeling wordt ontdekt en dat er geen richtlijnen bestaan voor een behandelbeleid. Aan de hand van drie casus willen we de kennis over deze zeldzame ziekte vergroten en het belang van het verwijzen van deze patiënten naar een tertiair centrum benadrukken.
Modification of electro gas weld metal microstructure reflecting mechanical property specifications in cruise vessel shipbuilding
Authors: Banaschik Richard , Brätz Oliver , Gericke Andreas , Henkel Knuth-Michael 
Published: April 2024

AbstractTo identify the microstructural factors effecting the electro gas welding (EGW) weld metal properties, this study investigated the influence of different prototype welding consumables and shielding gases on the microstructural composition and mechanical-technological properties. The aim was to adjust the weld metal properties as a trade-off between strength, ductility, and impact toughness to fulfill typical weld metal material specifications in cruise vessel shipbuilding under consideration of the manufacturing conditions at European shipyards. The microstructure is analyzed by quantitative metallography of the ferritic matrix, martensite-retained austenite (M/A) constituents, and non-metallic inclusions (NMI). The influence of the Ni content, the deoxidation concept by variation of Si and Ti contents, and different shielding gas activity by variation of the Ar proportions is discussed. The interaction of ferritic matrix with high acicular ferrite content of about 70 ± 10%, the existence of larger grain boundary ferrite formations, and the M/A morphology plus distribution are considered as the determining factors for the material properties.
Evaluation of antioxidant activity and fermentation properties of potential probiotic strain Lactiplantibacillus plantarum HY7720 in plant-based materials
Authors: Kim Ju-Yeon , Choi Eun Jung , Jang Woo Young , Kim Soo A. , Heo Kyeong , Kang Heerim , Kang Jeanne , Kim Yong-Tae , Shim Jae-Jung , Lee Jung-Lyoul , Lee Jae-Hwan 
Published: April 2024

AbstractPeople on vegan diets are at risk of being deficient in varied nutrients such as vitamin B12 and certain amino acids. In this study, we investigated vitamin B12-producing lactic acid bacteria (LAB) as well as the probiotic and antioxidant properties. Lactiplantibacillus plantarum HY7720 was screened from 22 strains of LAB that were isolated from different plant foods, and its growth ability and extracellular vitamin B12-producing capacity in vitamin B12-deficient medium were investigated. To determine whether HY7720 functions as a probiotic, survival rate in the simulated gastrointestinal tract and adhesion property to human intestinal epithelial cells of HY7720 were compared with positive control, Lacticaseibacillus rhamnosus GG (LGG). Moreover, the results showed that HY7720 recovered the gene expression levels of tight junction-associated proteins (TJPs), including TJP1, TJP2, occludin (OCLN), and claudin-1 (CLDN1) and inhibited the secretion levels of pro-inflammatory cytokines, including interleukin (IL)-6 and IL-8, in tumor necrosis factor (TNF)-α-stimulated Caco-2 cells. Furthermore, we verified that HY7720 exhibit the antioxidant potential, by showing its intracellular reactive oxygen species (ROS) scavenging ability in hydrogen peroxide (H2O2)-stimulated Caco-2 cells. The ability of HY7720 to ameliorate H2O2-induced cytotoxicity in Caco-2 cells was inhibited by mitogen-activated protein kinase (MAPK) inhibitors, indicating that its antioxidant responses are related to extracellular signal-regulated kinase (ERK) and c-JUN N-terminal kinase (JNK). This study also investigated the nutritional qualities of three plant-based materials (brown rice, white rice, and soy milk) fermented using HY7720. Collectively, HY7720 could be used as a promising probiotic strain for the prevention of nutritional deficiencies among people on vegetarian diets.
Close-to-nature forest management effects on soil nematodes and microbial activity in pine plantations on aeolian sands
Authors: Renčo Marek , Gömöryová Erika , Čerevková Andrea 
Published: April 2024

AbstractClose-to-nature forest management combines the economic use of forests with nature conservation in forest, aiming promote stability, productivity, diversity and continuity within forest ecosystems. While close-to-nature management is expected to positively impact the tree growth, its effect on the belowground micro-biota has been poorly investigated. Nematodes and microbes are species-rich and abundant soil microorganisms that have long been used as ecological indicators of soil health. In this study, was assessed the impact of close-to-nature forest management on soil nematode communities and microbial activity in the pine plantations on aeolian sands in Southern Slovakia, 10 years after the introduction of this management approach. Fifteen stands in close-to-nature forest managed and fifteen stands with applying standard forest management were chosen. Our findings revealed that close-to-nature forest management significantly increased the abundance of soil nematodes and nematode biomass in each of the plots. Moreover, close-to-nature forest management significantly increased the mean abundance of omnivores and predators as stress sensitive nematodes (c–p4, c–p5). Additionally, close-to-nature forest management reduces the proportion of stress tolerant nematodes (c–p1) and enrichment opportunists (c–p2), increased all maturity and structure indices as well as composite, structure, predator and omnivore footprints. Furthermore, close-to-nature forest management significantly increased soil moisture, soil carbon content, microbial biomass carbon, basal respiration and N-mineralization, and understory vegetation diversity. These findings suggest that close-to-nature management practice, resulting in forest of different ages, positively influenced nematode communities and microbial activity by changing the quantity and quality of resources associated with increased understory cover and diversity.
Rescue cervical cerclage in twin pregnancy with spontaneous cervical dilatation at 8-week gestation
Authors: Sharma Gaurav , Pradhan Samir , Zaidi Sara , Shreedharan Rinoy , Chandra Vipin , Bhoi Nihar Ranjan 
Published: April 2024

AbstractPremature spontaneous cervical dilatation can happen among pregnant women leading to miscarriage, preterm labor, or premature delivery. We present a case of twin pregnancy with spontaneous cervical dilatation and membranes bulging into the vagina at 8-week gestation. A 34-year-old primigravida presented to our clinic with complaints of cramping pain in the lower abdomen. Her per speculum pelvic examination showed evidence of dilated cervical os and amniotic membranes bulging through the cervix into the vagina. Her sonogram suggested a dichorionic diamniotic pregnancy of 8-week gestation. Her TVS examination revealed that the internal os was dilated. Both fetuses were alive with regular fetal heart rate. Rescue cervical cerclage by modified Shirodkar’s technique was done under general anesthesia. She was administered prophylactic antibiotics and tocolytic. She was closely followed up at regular intervals and observed for signs of chorioamnionitis. She delivered at 35 weeks of gestation with two female children with birth weights 2.3 kg and 2.1 kg, respectively.