bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orotic acid quantification in dried blood spots and biological fluids by hydrophilic interaction liquid chromatography tandem mass spectrometry
Authors: D'Apolito Oceania , Garofalo Daniela , Paglia Giuseppe , Zuppaldi Alfredo , Corso Gaetano 
Published: March 2010

AbstractOrotic acid (ORA) is an intermediate metabolite in the pathway of pyrimidine nucleotides; its urinary excretion is useful to diagnose the hereditary orotic aciduria and some hyperammonemic inherited defects of urea cycle enzymes and amino acid transporters. ORA analysis is based on stable isotope dilution by GC‐MS or LC‐MS/MS methods. We developed a fast assay that measures the ORA in dried blood spots (DBS), plasma and urine using hydrophilic interaction LC‐MS/MS. Within‐ and between‐day analytical imprecision (CV%) of three quality control levels, in plasma, DBS and urine, ranged from 0.8 to 14.1%, while the inaccuracy ranged from −13.5 to 9.4%. In healthy children (n=20), ORA concentrations were less than 0.69 μM in plasma, less than 0.82 μM in DBS and from 0.2 to 1.4 mmol/mol of creatinine in urine. A patient with citrullinemia showed ORA levels of 133 μM in plasma and 39 μM in DBS. A patient with hyperammonemia‐hyperornithinemia‐homocitrullinemia (HHH) syndrome presented a urinary ORA level of 9.1 mmol/mol of creatinine. The method is potentially able to discriminate affected patients from reference subjects; the clinical validation should be expanded on a higher number of patients.
RP‐LC×RP‐LC analysis of a tryptic digest using a combination of totally porous and partially porous stationary phases
Authors: Mondello Luigi , Donato Paola , Cacciola Francesco , Fanali Chiara , Dugo Paola 
Published: March 2010

AbstractDifferent chromatographic separation modes have been combined, in off‐line and on‐line approaches, attempting to achieve enhanced separation power for the analysis of complex proteome samples. Among these, the use of RP‐LC × RP‐LC brings in the added advantages of high peak capacity in both dimensions, capability of full automation, and the likelihood of direct hyphenation to MS. In this contribution, we achieved enhanced resolution in the first dimension, by serially coupling Bio wide pore C18 columns at basic pH, at moderate pressure. Selectivity was tuned using one short (3 cm) C18 column packed with partially porous particles for fast second‐dimension analysis, operated at acidic pH. The comprehensive system was configured around electronically activated two‐position, ten‐port valve for within‐loop automated fraction collection/re‐injection. A theoretical peak capacity of 3796 was calculated for the set‐up employing one basic column in the first dimension, while a peak capacity of 10 686 was attained with four times the length of stationary phase, even at the expense of longer analysis time. The system showed very good reproducibility of retention times and chromatographic peak areas (RSD less than 1.2 and 4%, respectively).
Structure‐Based Approaches to Target Fishing and Ligand Profiling
Authors: Rognan Didier 
Published: March 2010

AbstractChemogenomics is an emerging interdisciplinary field aiming at identifying all possible ligands of all possible targets. If one groups targets in columns and ligands in rows, chemogenomic approaches to drug discovery just fill the interaction matrix. Since experimental data do not suffice, several computational methods are currently actively developed to supplement time‐consuming and costly experiments. They are either designed to fill rows and thus profile a ligand towards a heterogeneous set of targets (target profiling) or to fill columns and thus identify novel ligands for an existing target (standard virtual screening). At the interface of both strategies are now true chemogenomic computational methods filling well defined areas in the matrix. The present review will focus on (protein) structure‐based approaches and illustrates major advances in this novel exciting field which is supposed to massively impact rational drug design in the next decade.
Theoretical investigation of nanowaveguide‐based optical coupler using mode expansion transfer matrix
Authors: Wang G. H. , Shum P. , Ren G. B. , Yu X. , Hu J. J. , Lin C. 
Published: March 2010

AbstractWe report a mode expansion transfer matrix method to describe the nanowaveguide‐based strongly coupling waveguide directional couplers, including slab nanowaveguide coupler, silicon‐on‐insulator (SOI) nanowires coupler, and silica nanofibers coupler. We propose a general mode expansion description of coupler without the assumption of weakly guiding. For the slab nanowaveguide case, all the coefficients inside those matrices could be identified theoretically using mode expansion method. The analytical results of coupler show excellent agreement with the simulation results obtained by the finite‐difference time‐domain method. For the nanofiber coupler, with the mode profiles obtained numerically using finite element method, similar matrix equation could be used for the guideline of nanofiber coupler design, which is the key issue of coupler‐based nanofiber devices and SOI nanowires devices. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1123–1129, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25093
Use of retrodirective array phase conjugation circuitry for near‐ and far‐field position angle of arrival detection
Authors: Buchanan N.B. , Fusco V. 
Published: March 2010

AbstractIn this article, we present position indication functionality as obtained by using a retrodirective array, thereby allowing location information extraction of the position of the remote transmitter with which the retrodirective array is cooperating.This is carried out using straightforward circuitry with no requirement for complex angle of arrival algorithms, thereby giving a result in real time enabling tracking of fast moving transmitters. We show using a 10 × 1 element retrodirective array, operating at 2.4 GHz that accuracies of far‐field angle of arrival of within ±1° over the arrays ±30° azimuth field of view are possible. While in the near‐field for angles of arrival of ±10° it is possible to extract the position of a dipole source down to a resolution of 0.32λ. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1031–1034, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25097
Simulation and measurement of inset‐fed microstrip patch antennas on BiNbO4 substrates
Authors: Filho R. Carneiro , Araújo J. H. , Ginani M. F. , d'Assunção A. G. , Martins R. A. , d'Assunção A. G. , Mendonça L. M. 
Published: March 2010

AbstractThis work presents an experimental investigation of the properties of microstrip patch antennas on bismuth niobate ceramic substrates. The substrate fabrication process and characterization are described. Several prototypes were built and measured for wireless communication systems. A good agreement was observed between measured and simulated results. The very high electrical permittivity of the ceramic substrate provided a reduction of the antenna dimensions. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1034–1036, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25098
Potential of hollow Al2O3 nanoparticles for reducing dielectric properties of Al2O3‐epoxy matrix composites in microwave frequency range
Authors: Utsuno S. , Matsumura K. , Kagawa Y. 
Published: March 2010

AbstractDielectric properties of hollow Al2O3 nanoparticle‐dispersed epoxy matrix composites in a frequency range from 18 to 30 GHz have been studied. Hollow Al2O3 nanoparticle‐dispersed composites show lower dielectric properties compared with those of solid α‐Al2O3 nanoparticle‐dispersed ones. The hollow part inside the nanoparticle reduces the effective dielectric constant of Al2O3 nanoparticle‐dispersed composites. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1069–1072, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25099
Injection‐locked frequency tripler with series‐tuned resonator in 0.13 μm CMOS technology
Authors: Jang Sheng‐Lyang , Chen Jhao‐Jhang , Liu Cheng‐Chen , Juang Miin‐Horng 
Published: March 2010

AbstractThis article proposes a CMOS LC‐tank injection locked frequency tripler (ILFT) fabricated in 0.13 μm CMOS process and describes the circuit design, operation principle and measurement results of the ILFT.The differential input/output ILFT circuit is realized with a first‐harmonic injection‐locked oscillator (ILO) stacked in series on two transconductance amplifiers used as a third harmonic generator. The first‐harmonic ILO with a series‐tuned LC resonator amplifies the signal from the third harmonic generated transconductance amplifier. At the supply voltage of 0.75 V, the free‐running frequency of the ILO is from 9.14 GHz to 9.40 GHz. At the incident power of 0 dBm, the total locking range is from the incident frequency 2.95 GHz to 3.43 GHz. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1107–1110, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25101
UWB time‐domain antennas beam scanning
Authors: Zhang L.‐H. , Ruan C.‐L. , Liu G.‐Y. 
Published: March 2010

AbstractUltra‐wideband (UWB) antenna is indispensable in impulse radar that transmits and receives short electromagnetic pulse signals and preserves the waveform well. Phased array antenna systems cannot meet the demand of the system. Optical true‐time delay techniques open the possibility of ultra‐wide bandwidth antenna systems, while at the same time meeting the stringent weight and size requirements. Continuously tunable true‐time delay techniques can provide continuous beam scanning. With advanced optoelectronic technique, fast wavelength tuning speed is possible. To detect and track moving‐target [Bi and Ren, Prog Electomagn Res 87 (2008), 15–41)], UWB time‐domain antenna array beam scanning is studied in this article. First, the theory of time‐domain antenna array scanning is analyzed, some useful conclusions are achieved. Then, an experiment system of UWB time‐domain antenna array scanning is built, which includes an antenna array, fiber‐optic true‐time delay device, and other equipments. Finally, the theoretical and experimental results combined to are made to validate the theory of UWB time‐domain antenna array beam scanning. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1110–1112, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25102
A compact UWB antenna with dual band‐notched characteristics
Authors: Edalati Arezou , Denidni Tayeb A. 
Published: March 2010

AbstractIn this letter, the design, the analysis, and the measurement results of a new compact planar ultra‐wideband CPW‐fed antenna with dual‐notched characteristics are presented. The radiating element is a planar square monopole with a circular base. A dual‐notched bands characteristic is obtained by etching a half‐circle slot in the square monopole and two L‐shaped slots in the ground plane. The measurement results show stable radiation patterns with broadband matched impedance from 3 GHz to 11 GHz for VSWR < 2, except two dual‐notched bands at 3.3–4 GHz and 5.2–5.8 GHz for filtering the WiMAX and WLAN signals. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1183–1186, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25105
Novel design of multiplexed sensors using a dual FBGs scheme
Authors: Nafisah S. , Hairi H. M. , Saktioto T. , Ali J. , Yupapin P. P. 
Published: March 2010

AbstractWe propose a new system of the multiplexed sensors using a series of fiber Bragg gratings (FBGs), where the gratings separation lengths, Bragg wavelength, dip length, and birefringence can be configured as the sensing information.The transmission spectrum of a dual fiber Bragg gratings has been derived. Value of separation length between two FBGs, dL, is varied from 0.5 to 5.5 cm. The dip of separation length affects the transmission spectrum, which is indicated by the numbers of minimum dip values. Results show that the increasing in the separation length (dip length) between two FBGs leads to the formation of phase shift and increases the number of minimum transmission dip. For the dual FBGs to be used as a Fabry‐Perot interferometer, it must have the smallest possible separation length. The multiplexed sensing application of more than two physical parameters can be operated by using such effects, for instance, strain, temperature, and gas sensor is plausible, while the self calibration between them is also available. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1218–1221, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25106
Novel ultra‐wideband bow‐tie antenna with high front‐to‐back ratio and directivity
Authors: Midrio M. , Boscolo S. , Sacchetto F. , Pigozzo F. M. , Capobianco A. D. 
Published: March 2010

AbstractWe present a novel directional ultra‐wideband antenna based on the bow‐tie geometry. The proposed design, unlike the conventional bow‐tie radiator, has an inherently different radiation mechanism, which relies on magnetic currents excited in properly designed slots. This in turn allows to maintain good antenna performance even when a planar reflector is placed below the antenna that gives rise to high front‐to‐back ratio and directivity over a band extending from 4.8 to 6.1 GHz. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1016–1020, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25108
Erratum: A planar hybrid antenna for UWB application
Authors: Chen Wen‐Shan , Lin Chi‐Huang 
Published: March 2010

AbstractOriginally published in Microwave Opt Technol Lett 51: 1243–1246, 2009
. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1223, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25109
Wideband dual‐frequency right triangular microstrip antenna with parallel narrow slits
Authors: Sharma Vijay , Saxena V. K. , Saini J. S. , Bhatnagar D. , Sharma K.B. , Pal D. , Joshi L. M. 
Published: March 2010

AbstractThe radiation performance of a right triangular microstrip antenna (RTMA) having two parallel narrow slits is simulated using IE 3D software, and later this antenna is designed on glass epoxy FR‐4 substrate with an air gap and tested in free space. The slit length, width, and thickness of air gap are optimized to attain best performance from the modified RTMA structure. The designed antenna with an air gap of 1.0 mm resonates at two different frequencies and presents 29% bandwidth. The antenna matches well with the feed line for both the resonance frequencies. The simulated E‐ and H‐plane radiation patterns are presented at four frequencies with in the range of frequencies where broadband response is obtained. These four patterns are almost identical in shape and their direction of maximum radiation intensity is normal to the patch geometry. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1082–1087, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25113
A variable gain amplifier using a very‐high speed OTA
Authors: Zheng You , Saavedra Carlos E. 
Published: March 2010

AbstractA variable gain amplifier is demonstrated using only one fully‐differential operational transconductance amplifier (OTA) as the core circuit element.Gain control is achieved by varying the transconductance of the OTA and by using an output buffer circuit to sum the output signals of the OTA in the correct phase relationship. The circuit was designed and fabricated using 0.18 μm CMOS technology. Measured results show a gain control range of 15 dB between 1 GHz and 3 GHz and the input and output reflection coefficients are below −10 dB and −20 dB, respectively. The output power of the amplifier is +2.3 dBm at its 1‐dB compression point. The chip has a maximum DC power consumption 12.6 mW and it measures 0.25 mm2 including bonding pads. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1112–1116, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25114
An integrated compact coplanar waveguide high‐pass filter implemented on high resistivity silicon substrate
Authors: Hung Cheng‐Yuan , Weng Min‐Hang , Yang Ru‐Yuan , Wu Hung‐Wei 
Published: March 2010

AbstractIn this article, the fabrication of a compact and high performance semi‐lumped coplanar waveguide high‐pass filter (CPW‐HPF) implemented on high resistivity silicon (HRS) substrate is proposed.The design procedure and the equivalent circuit of the proposed semi‐lumped CPW‐HPF is discussed. The filter structure is simple, and the performances are fairly good. This designed filter at cutoff frequency fc of 21.6 GHz has very good measured characteristics including a balance passband of S21 of −0.5 ± 0.3 dB and a sharp band edge rejection. Experimental results of the fabricated filter show a good agreement with the predicted results. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1150–1153, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25116
Design of compact and wideband metamaterial balun based on closed‐form solutions
Authors: Jung Youn‐Kwon , Lee Bomson 
Published: March 2010

AbstractThis letter presents a very compact (17.5 mm × 24.2 mm or 0.18 λ0 × 0.24 λ0) and wideband balun at 3 GHz designed using the derived closed‐form solutions. The EM‐simulated difference of the transmitted signals at two ports is less than 0.6 dB from 2.45 to 6 GHz (118% at 3 GHz). Based on 180° ± 10° phase difference, the measured bandwidth of the proposed balun is 3.84 GHz from 2.16 to 6 GHz (or 128% at 3 GHz). © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1153–1156, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25117
Design of planar bandpass filters from tapered slot resonators
Authors: Abbosh Amin , Bialkowski Marek , Thiel David 
Published: March 2010

AbstractA compact planar bandpass filter is designed using a tapered slot resonator, which is formed using two tapered slot antennas connected in a face‐to‐face configuration. The tapering profile and dimensions of the resonator control the characteristics of the filter. The success of the method is demonstrated via full wave electromagnetic simulations and measurements. Passbands of 30–50% centred at about 6 GHz with an insertion loss of less than 1 dB and a peak‐to‐peak group delay of less than 0.5 ns are achieved in two filters having different tapering profiles and fabricated on RT6010 substrate with an overall dimension of 25 mm × 30 mm. The use of an open‐ended series stub within the coplanar waveguide feeder of the filters extends their high stopband beyond 15 GHz. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1190–1194, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25118
Dual‐band unequal Wilkinson power divider with reduced length
Authors: Kim TaeGyu , Lee Byungje , Park Myun‐Joo 
Published: March 2010

AbstractA new dual‐band Wilkinson divider structure is proposed for the arbitrary power division ratio and matched output ports.The compact dual‐band stubbed Π sections are employed in both the Wilkinson divider and the output matching section. It has simple structure based on the compact open stub topology and the overall divider length can be reduced in half as compared with similar works based on the two cascaded section transformers. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1187–1190, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25119
Coplanar stripline ultra‐wideband compact uniplanar bandpass filter with a notched band
Authors: Mandal Mrinal Kanti , Chen Zhi Ning 
Published: March 2010

AbstractIn this article, a coplanar stripline (CPS) coupling configuration is presented for a compact, ultra‐wideband (UWB), uniplanar bandpass filter with a notched band.The passband width of the filter is greatly increased by adding two parallel strips with a coupled‐CPS section. Furthermore, spur line is used to create a notched band in the UWB passband to reject the undesired wireless local‐area network radio signals in 5 GHz bands. The notched band can be tuned by varying the spur line length. One prototype bandpass filter is fabricated with overall size of 17 × 7.2 mm2on a 0.813‐mm thick substrate with dielectric constant of εr= 3.38. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1201–1203, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25124
The hybrid higher order MoM‐UTD formulation for electromagnetic radiation problems
Authors: Liu Zi‐Liang , Yang Juan , Liang Chang‐Hong 
Published: March 2010

AbstractThis article presents a new efficient hybrid higher order MoM‐UTD method. It overcomes the limitation of traditional MoM‐UTD method, which is difficult to be applied to the arbitrary structures because of complex ray tracing. Using the large quadrilateral patches and higher order basis functions, the hybrid method in this article can save much more computer memory than the traditional low‐order MoM with RWG basis functions. So, it is feasible for complex and electrically large structures. Good accuracy is achieved as the numerical results illustrated. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1087–1091, 2010; Published online in Wiley InterScience (www. interscience.wiley.com). DOI 10.1002/mop.25125
Develop compact dual‐band bandpass filters on the aluminum oxide
Authors: Yang Hung‐Chi , Yang Cheng‐Fu , Cheng Chien‐Ming 
Published: March 2010

AbstractFor the purpose of minimizing the dual‐band bandpass filters (2.4 and 5.7 GHz), two stepped impedance resonator structures are modified and involved in a pair of distorted coupled lines to form a compact structure.And because the designed filter is printed on the high quality factor and dielectric constant aluminum oxide ceramic substrate by the screen‐printing technique, the characteristics of the filters could be improved and the size of the filters could be minimized to only 22.2 × 12 mm2. Furthermore, the modified SIR structure can be used to tune the second resonant frequency (harmonic) for the applications of dual bands, and the modified coupled line structures can be used to excite additional transmission zeros and adjust its locations, which can improve the characteristics of the filters effectively. In this article, the optimum measured insertion loss and bandwidth for 2.4 GHz are −0.98 dB and 11.1%, respectively, and for 5.7 GHz are −1.05 dB and 10.1%, respectively. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1091–1094, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25126
Design of a new type of metamaterial radome for low frequencies
Authors: Latrach M. , Rmili H. , Sabatier C. , Seguenot E. , Toutain S. 
Published: March 2010

AbstractA new type of radome was designed around 2 GHz, comprising alternately layers with negative permeability and positive index of refraction materials.The negative permeability, obtained by the square ring resonators (SRRs) network and the thickness of the radome are optimized so that the radiated electromagnetic waves generated by the antenna are passing through with minimum reflection. The compact electrical size of the SRR structure (∼λ/20) was obtained by optimizing the geometrical and electrical parameters as increasing the coupling between the resonators. The effect of the radome on the antenna characteristics is evaluated by simulation and measurements with good agreement. Enhancements of the gain, directivity, and impedance bandwidth are also observed. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 1119–1123, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.25127