bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and safety of a selective estrogen receptor β agonist, ERB‐041, in patients with rheumatoid arthritis: A 12‐week, randomized, placebo‐controlled, phase II study
Authors: Roman‐Blas Jorge A. , Castañeda Santos , Cutolo Maurizio , Herrero‐Beaumont Gabriel 
Published: June 2010

AbstractObjectiveSelective estrogen receptor β (ERβ) agonists have demonstrated relevant antiinflammatory effects in different animal models. This study aimed to compare the efficacy and safety of one of these agonists, ERB‐041, in subjects with rheumatoid arthritis (RA).MethodsA total of 291 patients with active RA receiving stable doses of methotrexate were randomized to receive 5, 25, or 75 mg of ERB‐041 or placebo for 12 weeks. The primary end point was the American College of Rheumatology 20% improvement criteria (ACR20) at 12 weeks. Secondary end points included the ACR 50% improvement criteria (ACR50) and the ACR 70% improvement criteria (ACR70) responses, health outcomes measures, C‐reactive protein (CRP) levels, and potential exposure‐response relationships. Medical history, physical examination, and laboratory values were obtained at screening, baseline, and weeks 2, 4, 8, and 12.ResultsNo statistically significant difference for the ACR20 was found between the ERB‐041 treatment and placebo groups (P = 0.518). Nor was a significant difference observed for ACR50 and ACR70 responses, health outcomes measures, CRP levels, and overall incidence of adverse events among all groups. Forty‐four subjects (15.1%) discontinued the study and the rate of discontinuation was similar among the treatment groups. The most commonly reported treatment‐emergent adverse events were headache (7.6%), nausea (6.2%), infection (4.8%), and bronchitis (4.1%). None of the adverse events was considered treatment related.ConclusionAlthough well tolerated and safe, ERB‐041 failed to demonstrate antiinflammatory efficacy in RA patients, despite evidence of strong activity in preclinical arthritis models. These results suggest that selective ERβ agonists would not have effects on regulating inflammatory response in RA. Nevertheless, further studies are warranted to establish their efficacy in inflammatory arthritis.
Patient‐reported outcome assessment in vasculitis may provide important data and a unique perspective
Authors: Herlyn Karen , Hellmich Bernhard , Seo Philip , Merkel Peter A. 
Published: June 2010

AbstractObjectiveTo assess patients' self‐estimates of the burden of disease in vasculitis and to compare data across patient populations from the US, Germany, and the UK. Outcome assessment in vasculitis primarily focuses on physician evaluations of disease activity and damage. Little is known about the patients' perspectives regarding the burden of disease.MethodsPatients ranked (scale 0–5) a list of vasculitis‐related items to estimate a combination of pain, interference with daily function, discomfort and/or annoyance, anxiety/psychological impact, and medical importance. Patients were also asked to list the 5 most troublesome aspects of the disease.ResultsData from 264 patients with vasculitis from 3 countries were collected. Wegener's granulomatosis was the predominant disease, comprising 63% of the cohort. Diagnoses were confirmed by physicians in 98% of cases. The most common item from the free‐text sections was fatigue (75%), followed by pain (31%), musculoskeletal symptoms (24%), difficulty breathing (19%), financial aspects (13%), nasal discharge/crusting (14%), and weight gain (10%). Rankings of individual items varied substantially: fatigue (3.5), loss of energy (3.4), weight gain (3.1), joint pain (3.0), and sinusitis (3.0) were the highest‐ranked symptoms among those manifestations experienced by at least 50% of patients. Several severe manifestations (e.g., dialysis, seizures, oxygen dependency) were ranked lower (<3.0).ConclusionFatigue and reduced energy level are considered the most important disease burdens by patients with vasculitis; manifestations associated with organ damage were rated lower. The patients' perspectives of the impact of vasculitis differ from the physicians' ratings. Future outcome assessment in vasculitis should include the patients' perspectives.
LMI solutions to the mixed ℋ︁−/ℋ︁∞fault detection observer design for linear parameter‐varying systems
Authors: Wei X. , Verhaegen M. 
Published: June 2010

AbstractThis paper addresses the mixed ℋ︁−/ℋ︁∞fault detection observer design issue for a class of linear parameter‐varying (LPV) systems. Analogous to the definition of the quadratic ℋ︁∞performance for LPV systems and the ℋ︁−index for linear time invariant (LTI) systems, the quadratic ℋ︁−index and the affine quadratic ℋ︁−index for LPV systems are defined in terms of linear matrix inequalities (LMIs). The first algorithm for designing the mixed ℋ︁−/H∞observer is proposed, which aims at minimizing the quadratic ℋ︁∞performance and maximizing the quadratic ℋ︁−index of the observer error dynamic systems. To reduce the conservativeness of this algorithm, the affine quadratic ℋ︁∞performance and the affine ℋ︁−index for LPV systems are utilized. The robustness conditions and affine ℋ︁−index conditions for the underlying observer optimization issue are formulated as parameter‐dependent LMIs. The Gridding technique and multi‐convexity concept are applied, respectively, for reducing the parameter‐dependent LMIs to finite LMI constraints. Correspondingly, two iterative algorithms are proposed. Furthermore, the threshold design and the estimation of the worst undetectable fault size are investigated. An example is studied to demonstrate the effectiveness of the proposed algorithms. Copyright © 2010 John Wiley & Sons, Ltd.
Stabilization of controlled positive discrete‐time T‐S fuzzy systems by state feedback control
Authors: Benzaouia Abdellah , Hmamed Abdelaziz , EL Hajjaji Ahmed 
Published: June 2010

AbstractThis paper deals with sufficient conditions of asymptotic stability and stabilization for nonlinear discrete‐time systems represented by a Takagi–Sugeno‐type fuzzy model whose state variables take only nonnegative values at all timestfor any nonnegative initial state. This class of systems is called positive systems. The conditions of stabilizability are obtained with state feedback control. This work is based on multiple Lyapunov functions. The results are presented in linear matrix inequalities form. A real plant is studied to illustrate this technique. Copyright © 2010 John Wiley & Sons, Ltd.
Integrative Approaches to Hybrid Multifunctional Materials: From Multidisciplinary Research to Applied Technologies
Authors: Nicole Lionel , Rozes Laurence , Sanchez Clément 
Published: June 2010

AbstractAchieving nanostructured or hierarchical hybrid architectures involves cross‐cutting synthetic strategies where all facettes of chemistry (organic, polymers, solid‐state, physical, materials chemistries, biochemistry, etc…︁), soft matter and ingenious processing are synergistically coupled. These cross‐cutting approaches are in the vein of bio‐inspired synthesis strategies where the integration of different areas of expertise allows the development of complex systems of various shapes with perfect mastery at different size scales, composition, porosity, functionality, and morphology. These strategies coined “Integrative Chemistry” open a land of opportunities to create advanced hybrid materials with organic‐inorganic or bio‐inorganic character. These hybrid materials represent not only a new field of basic research where creative chemists can express themselves, but also, via their remarkable new properties and multifunctional nature, hybrids are allowing the emergence of innovative industrial applications in extremely diverse fields.
Reproducibility of tricuspid regurgitant jet velocity measurements in children and young adults with sickle cell disease undergoing screening for pulmonary hypertension
Authors: Liem Robert I. , Young Luciana T. , Lay Amy S. , Pelligra Stephanie A. , Labotka Richard J. , Thompson Alexis A. 
Published: June 2010

AbstractThe reproducibility of tricuspid regurgitant jet velocity (TRJV) measurements by Doppler echocardiography has not been subjected to systematic evaluation among individuals with sickle cell disease (SCD) undergoing screening for pulmonary hypertension. We examined sources of disagreement associated with peak TRJV in children and young adults with SCD. Peak TRJV was independently measured and interpreted a week apart by separate sonographers and readers, respectively, in 30 subjects (mean age, 15.8 ± 3.3 years) who provided 120 observations. We assessed intra‐/inter‐reader, intra‐/inter‐sonographer, sonographer‐reader, and within subject agreement using Intraclass Correlation Coefficient (ICC) and Cohen's kappa (κ). Agreement was examined graphically using Bland‐Altman plots. Although sonographers could estimate and measure peak TRJV in all subjects, readers designated tricuspid regurgitation nonquantifiable in 10–17% of their final interpretations. Intra‐reader agreement was highest (ICC = 0.93 [95% CI 0.86, 0.97], P = 0.0001) and within subject agreement lowest (ICC = 0.36 [95% CI 0.02, 0.64], P = 0.021) for single TRJV measurements. Similarly, intra‐reader agreement was highest (κ = 0.74 [95% CI 0.53, 0.95], P = 0.0001) and within subject lowest (κ = 0.14 [95% CI −0.17, 0.46], P = 0.38) when sonographers and readers categorized TRJV measurements. On Bland‐Altman plots, absolute differences in observations increased with higher mean TRJV readings for intra‐/inter‐reader agreement. Peak TRJV measurements in individual children and young adults with SCD are affected by several sources of disagreement, underscoring the need for methodological improvements that ensure reproducibility of this screening modality for making clinical decisions in this population. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.
Use of parenteral iron products and serious anaphylactic‐type reactions
Authors: Wysowski Diane K. , Swartz Lynette , Vicky Borders‐Hemphill B. , Goulding Margie R. , Dormitzer Catherine 
Published: June 2010

AbstractControversy exists about the safety of the parenteral iron dextran products, Dexferrum and INFeD, which have been associated with rare, serious anaphylactic‐type reactions. In the United States, their product labels carry boxed warnings of this adverse event; some have called for the withdrawal from marketing of the higher molecular weight Dexferrum. Between 2002 and 2007, sales of Dexferrum, INFeD, and iron gluconate Ferrlecit declined 32.5%, 21%, and 4.8%, respectively, while sales of iron sucrose Venofer increased 160%. Voluntary reports submitted to the Food and Drug Administration show anaphylactic reactions and symptoms for the four parenteral iron products. Because of underreporting, possible differential reporting, absence of iron dextran brand names, and incomplete use (denominator) data, incidence rates and relative risk estimates cannot be calculated. U.S. death certificate data show that for most years from 1979 through 2006, no more than 3 deaths per year were coded to “adverse events in therapeutic use of iron preparations;” brand names were not consistently recorded. Emergency department data show small numbers of visits for treatment of allergic reactions with intravenous iron preparations. The data presented herein show that allergic reactions are possible with all four parenteral iron products, and it is difficult to determine which product has the largest risk based on sales data, voluntarily submitted adverse event reports, death certificates, ED visits, and observational studies performed to date. To help differentiate risk among the parenteral iron products, the brand name of the product always should be provided on medical records, death certificates, and adverse drug reaction reports. Am. J. Hematol., 2010. Published 2010 Wiley‐Liss, Inc.
The refinement of the critical region for the 2q31.2q32.3 deletion syndrome indicates candidate genes for mental retardation and speech impairment
Authors: Cocchella Alessandro , Malacarne Michela , Forzano Francesca , Marciano Carmela , Pierluigi Mauro , Perroni Lucia , Faravelli Francesca , Di Maria Emilio 
Published: June 2010

AbstractCurrent literature provides more than 30 patients with interstitial deletions in chromosome 2q31q33. Only a few of them were studied using high‐resolution methods. Among these, two patients had presented with a particular consistence of some clinical features associated to a deletion between bands q31.2 and q32.3 of chromosome 2. This clinical pattern, labeled as “2q31.2q32.3 syndrome,” consists of multiple dysmorphisms, developmental delay, mental retardation and behavioural disturbances. We report an adult female patient with a 4.4 Mb deletion in the 2q31.2q32.3 region, showing facial dysmorphisms, mental retardation and absence of speech. The region overlaps with the deletion found in the two cases previously reported. The critical region points to a few genes, namely NEUROD1, ZNF804A, PDE1A, and ITGA4, which are good candidates to explain the cognitive and behavioural phenotype, as well as the severe speech impairment associated with the 2q31.2q32.3 deletion. © 2010 Wiley‐Liss, Inc.This article was published online on 15 June 2010. One error was subsequently identified. Acknowledgement section has now been added. This notice is included in the online and print versions to indicate that both have been corrected 14 September 2010.
Quasi‐particle peak due to magnetic order in strongly correlated electron systems
Authors: Zaleski T.A. , Kopeć T.K. 
Published: June 2010

AbstractWe study the electron spectral function of the antiferromagnetically ordered phase of the three dimensional Hubbard model, using recently formulated low‐energy theory based on the 2D half‐filled Hubbard model which describes both collective spin and charge fluctuations for arbitrary value of the Coulomb repulsion U. The model then is solved by a saddle‐point approximation within the CP1 representation for the Neel field. The single‐particle properties are obtained by writing the fermion field in terms of a U(1) phase, Schwinger boson SU(2) fields and a pseudofermion variables. We demonstrate that the appearance of a sharp peak in the electron spectral function in the antiferromagnetic state points to the emergence of the bosonic mode, which is associated with spin ordering.
Alteration of sensory neurons and spinal response to an experimental osteoarthritis pain model
Authors: Im Hee‐Jeong , Kim Jae‐Sung , Li Xin , Kotwal Naomi , Sumner Dale R. , van Wijnen Andre J. , Davis Francesca J. , Yan Dongyao , Levine Brett , Henry James L. , Desevré Jacques , Kroin Jeffrey S. 
Published: June 2010

AbstractObjectiveTo verify the biologic links between progressive cellular and structural alterations within knee joint components and development of symptomatic chronic pain that are characteristic of osteoarthritis (OA), and to investigate the molecular basis of alterations in nociceptive pathways caused by OA‐induced pain.MethodsAn animal model of knee joint OA pain was generated by intraarticular injection of mono‐iodoacetate (MIA) in Sprague‐Dawley rats, and symptomatic pain behavior tests were performed. Relationships between development of OA with accompanying pain responses and gradual alterations in cellular and structural knee joint components (i.e., cartilage, synovium, meniscus, subchondral bone) were examined by histologic and immunohistologic analysis, microscopic examination, and microfocal computed tomography. Progressive changes in the dynamic interrelationships between peripheral knee joint tissue and central components of nociceptive pathways caused by OA‐induced pain were examined by investigating cytokine production and expression in sensory neurons of the dorsal root ganglion and spinal cord.ResultsWe observed that structural changes in components of the peripheral knee joint correlate with alterations in the central compartments (dorsal root ganglia and the spinal cord) and symptomatic pain assessed by behavioral hyperalgesia. Our comparative gene expression studies revealed that the pain pathways in MIA‐induced knee OA may overlap, at least in part, with neuropathic pain mechanisms. Similar results were also observed upon destabilization of the knee joint in the anterior cruciate ligament transection and destabilization of the medial meniscus models of OA.ConclusionOur results indicate that MIA‐induced joint degeneration in rats generates an animal model that is suitable for mechanistic and pharmacologic studies on nociceptive pain pathways caused by OA, and provide key in vivo evidence that OA pain is caused by central sensitization through communication between peripheral OA nociceptors and the central sensory system. Furthermore, our data suggest a mechanistic overlap between OA‐induced pain and neuropathic pain.
Extracting historical time periods from the Web
Authors: de Boer Viktor , van Someren Maarten , Wielinga Bob J. 
Published: June 2010

AbstractIn this work we present an automatic method for the extraction of time periods related to ontological concepts from the Web. The method consists of two parts: an Information Extraction phase and a Semantic Representation phase. In the Information Extraction phase, temporal information about events that are associated with the target instance are extracted from Web documents. The resulting distribution is normalized and a model is fit to it. This distribution is then converted into a Semantic Representation in the second phase. We present the method and describe experiments where time periods for four different types of concepts are extracted and converted to a time representation vocabulary, based on the TIMEX2 annotation standard.
ChemInform Abstract: Theoretical Studies of B2Lin (n = 1—4).
Authors: Srinivas Gantasala Naga , Hamilton Tracy P. , Boatz Jerry A. , Lammertsma Koop 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cationic Ordering in Tysonite Type Structures. Part 1. Crystal Structure of BaTeF6.
Authors: Ider A. , El Farissi M. , Laval J. P. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Channel Structure in the New BiCoPO5. Comparison with BiNiPO5. Crystal Structure, Lone Pair Localization and Infrared Characterization.
Authors: Ketatni M. , Abraham F. , Mentre O. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Silver‐Ion Conduction Pathways in Ag5IP2O7.
Authors: Adams Stefan , Preusser Andrea 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rb2MoS4.
Authors: Ellermeier Jan , Naether Christian , Bensch Wolfgang 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tl2MoO4 at 350 K.
Authors: Friese K. , Madariaga G. , Breczewski T. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Refinement of CaBa2(HPO4)2 (H2PO4)2.
Authors: Tahar Lotfi Ben , Smiri Leila , Driss Ahmed 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pulsed Sonoelectrochemical Synthesis of Cadmium Selenide Nanoparticles.
Authors: Mastai Y. , Polsky R. , Koltypin Yu. , Gedanken A. , Hodes G. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal Structure of ((NH3CH2CH2)3N) 2P6O18×6H2O.
Authors: Marouani H. , Rzaigui M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal Structure of the Cyclooctaphosphate K2Mn2P8O24.
Authors: Murashova E. V. , Chudinova N. N. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ruthenium Nitrosocompounds with Oxygen‐Containing Tetrahedral Anions of d0‐Metals. The Crystal Structure of Tetraamminehydroxonitrosoruthenium(IV) Chromate Monohydrate [Ru(NO)(OH)(NH3)4] (CrO4)×H2O.
Authors: Kokunova V. N. , Minacheva L. Kh. , Kokunov Yu. V. , Sergienko V. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Orbital Calculations for the Reactions of 2,5‐Dimethylpyrrole with Phenylsulfonyl Chloride.
Authors: Seo Mi‐Kyung , Kim Jin‐Beom , Seong Seeyearl , Shim Young‐key 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Alkylation and Phenylation of [60]‐ and [70]‐Fullerenes by the Reaction with Ketones in the Ionization Chamber of a Mass Spectrometer.
Authors: Shilova Elena A. , Lyakhovetsky Yury I. , Tumanskii Boris L. , Belokon' Alexander I. , Nekrasov Yurii S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.