bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunogenicity and Protective Capacity of Sugar ABC Transporter Substrate-Binding Protein against Streptococcus suis Serotype 2, 7 and 9 Infection in Mice
Authors: Yan Zujie , Pan Ruyi , Zhang Junjie , Sun Jianhe , Ma Xiaochun , Dong Nihua , Yao Xiaohui , Wei Jianchao , Liu Ke , Qiu Yafeng , Sealey Katie , Nichols Hester , Jarvis Michael A. , Upton Mathew , Li Xiangdong , Ma Zhiyong , Liu Juxiang , Li Beibei 
Published: May 2024

Background: Streptococcus suis (S. suis) is a Gram-positive bacterium that causes substantial disease in pigs. S. suis is also an emerging zoonoses in humans, primarily in Asia, through the consumption of undercooked pork and the handling of infected pig meat as well as carcasses. The complexity of S. suis epidemiology, characterized by the presence of multiple bacterial serotypes and strains with diverse sequence types, identifies a critical need for a universal vaccine with the ability to confer cross-protective immunity. Highly conserved immunogenic proteins are generally considered good candidate antigens for subunit universal vaccines. Methods: In this study, the cross-protection of the sugar ABC transporter substrate-binding protein (S-ABC), a surface-associated immunogenic protein of S. suis, was examined in mice for evaluation as a universal vaccine candidate. Results: S-ABC was shown to be highly conserved, with 97% amino acid sequence identity across 31 S. suis strains deposited in GenBank. Recombinantly expressed S-ABC (rS-ABC) was recognized via rabbit sera specific to S. suis serotype 2. The immunization of mice with rS-ABC induced antigen-specific antibody responses, as well as IFN-γ and IL-4, in multiple organs, including the lungs. rS-ABC immunization conferred high (87.5% and 100%) protection against challenges with S. suis serotypes 2 and 9, demonstrating high cross-protection against these serotypes. Protection, albeit lower (50%), was also observed in mice challenged with S. suis serotype 7. Conclusions: These data identify S-ABC as a promising antigenic target within a universal subunit vaccine against S. suis.
Inclusive Business and Its Contribution to Employing People with Disabilities
Authors: Felix* Antonius , Wijaya Felix Jonathan , Venita Erin , Melisa Melisa , Patricia Angel , Sidarta Eric , Athaliav Tania 
Published: May 2024

The purpose of this research is to investigate how Kopi Sunyi's unique approach to inclusive employment and education influences customer perceptions and fosters inclusivity. Utilizing a comprehensive research methodology, including analysis of online reviews, direct visits, and observational data, this study offers valuable insights into Kopi Sunyi's role in fostering inclusivity and challenging societal norms. Results reveal that Kopi Sunyi's commitment to providing employment opportunities and inclusive education through the Sunyi Academy program has positively influenced customer perceptions, fostering a welcoming atmosphere and friendly service. The cafe's efforts in challenging societal stigmas have led to increased awareness and support for individuals with disabilities in the workforce. The findings underscore the transformative potential of inclusive business practices in promoting social inclusion and empowerment.
Keyword: Workplace Disabilities; Inclusive Environment; Equality in Workplace; Social Inclusion; Job Opportunities
De la ville bleue à la métropole grise. Fondation, protection et destruction de Kökeqota (Huehaote)
Authors: Charleux Isabelle 
Published: May 2024

From the Blue City to the Grey Metropolis. Foundation, protection and destruction of Kökeqota (Huhehaote)
Kökeqota, the “Blue City”, capital of the Inner Mongolia Autonomous Region in China, had preserved an architectural heritage of great richness until the 1990s. In 1987 it merited inclusion among the “nationally famous historic and cultural cities” of China. Yet, faced with strong demographic, economic, and urban expansion, the architectural heritage, although “protected”, suffers irreversible degradation. The old city, except for a few temples, is being razed. After a presentation of the city’s history, of its transformations during the Communist period, of the heritage policy, and in particular of the restoration of the religious structures, the article considers their state in 2002, evaluating the extent of the destruction and seeking to understand what is currently at stake.
De l’Évangile à l’ours en Russie impériale : Comment faire prêter serment à des peuples animistes ?
Authors: Lambert Jean-Luc 
Published: May 2024

From the Gospel to the bear in Imperial Russia: how were animist peoples made to swear an oath?
In Imperial Russia, oaths were of considerable importance. Traditionally one would swear an oath by kissing the cross or placing ones hand on the Bible. All male subjects had to swear an oath of loyalty to the tsar, and oaths were a part of common judicial procedures. But, how did the non-Christian peoples of the Russian Empire, in particular members of the animistic minorities of Siberia, swear an oath? This case study shows how the form of a ritual may be adapted in order to guarantee its efficacy. The analysis shows that the Russian authorities created ‘bear’s oaths’, during which animists were supposed to kiss the skull or the paw of a bear when swearing an oath. In this way, the bear was construed as a divinity which could not be cheated and which could therefore serve as a guarantee for the validity of an oath. As a consequence, when Siberians killed a bear, they immediately deceived it by accusing the Russians of the death of the animal; furthermore, Siberian rituals organized to honour this ‘divine bear’ became increasingly complex.
Exploring the Impact of Online Teaching Environment on EFL Teachers’ Professional Identity
Authors: Fayyad Abuhussein Haya , Badah Amjad 
Published: May 2024

The impact of COVID-19 on the higher education sector has extended beyond using alternative technological methods. It has also influenced the professional identities of instructors themselves. This study aims to investigate EFL instructors’ perceptions of the impact of online teaching on identity transformation during the COVID-19 lockdown. It also investigates how online teaching has affected teachers’ professional identity in relevant aspects. The study was conducted during the first academic semester of 2022/ 2023. The researchers adopted a mixed research methodology that involved both quantitative and qualitative research techniques. A questionnaire was distributed to (44) EFL instructors, and semi-structured interviews were conducted with (8) EFL instructors at the Department of Languages and Translation at a Palestinian University, Palestine. Appropriate quantitative and qualitative analyses were utilized to figure out participants’ responses to the questionnaire and the interviews. The results of the survey revealed that online teaching positively influenced instructors’ social relations with their colleagues and students, enhanced the teaching process, and promoted instructors’ self-esteem. As for the interviews, the findings showed the substantial impact of online teaching on EFL instructors’ identity in terms of their professional needs, self-awareness and self-esteem, relationships with learners, relationships with colleagues, and their perspectives towards their institution. Hence, some recommendations were suggested.
Faktor-Faktor Yang Berhubungan Dengan Length of Stay di Instalasi Gawat Darurat
Authors: Roselita Windy , Kristi Layun Rining Marina , Abiyoga Aries , Rusdi Rusdi 
Published: May 2024

Latar Belakang: Emergency Department Length of Stay, bisa berarti interval waktu antara kedatangan pasien ke UGD dengan waktu pasien secara fisik meninggalkan UGD. LOS di Emergency Department, ditandai dengan waktu yang tidak tepat lama sebelum keberangkatan akhir untuk tempat tidur di rumah sakit, rumah, atau fasilitas lain diyakini mempengaruhi hasil klinis. Lamanya LOS tentu akan memicu risiko terjadinya hal yang tidak diinginkan, mempengaruhi tingkat keselamatan menurunkan mutu pelayanan rumah sakit dan kepuasan pasien. Tujuan: Tujuan dari studi ini guna mengetahui Faktor-faktor yang Berhubungan Dengan Length of Stay di Instalasi Gawat Darurat RSUD Akhmad Berahim Kabupaten Tana Tidung. Metode: Penelitian ini merupakan penelitian kuantitatif berjenis deskriptif analitik. Sampel pada penelitian ini berjumlah 85responden menggunakan metode purposive sampling dengan pendekatan cross sectional. Menggunakan lembar observasi Length of Stay. Hasil: Analisa data bivariat memakai uji chi square pada faktor Waktu Pemeriksaan Diagnostik adalah p 0.003 kurang 0.05 yang berarti ada hubungan antara Waktu Pemeriksaan Diagnostik dengan Length of Stay di Instalasi Gawat Darurat RSUD Akhmad Berahim Tana Tidung. Sedangkan faktor Waktu Triase p 1.000 lebih 0.05, faktor Waktu Konsultasi p 0.057 lebih 0.05, faktor Cara Kedatangan p 0.743 lebih 0.05 dan faktor Jenis Kasus p 0.388 lebih 0.05 keempatnya tidak ada hubungan dengan Length of Stay di Instalasi Gawat Darurat RSUD Akhmad Berahim Tana Tidung. Kesimpulan: Adanya Hubungan Waktu Pemeriksaan Diagnostik dengan Length of Stay di Instalasi Gawat Darurat RSUD Akhmad Berahim Tana Tidung. Tidak adanya hubungan antara Waktu Triase, Waktu Konsultasi, Cara Kedatangan, dan Jenis kasus dengan Length of Stay di Instalasi Gawat Darurat RSUD Akhmad Berahim Tana Tidung.
Factors Shaping Commitment and Resource Allocation in Managing Quality Tourism Destinations
Authors: Dewi Ike Janita , Ginting Ginta 
Published: May 2024

The research aims at analyzing factors affecting the implementation of the quality tourism paradigm by tourism villages. A tourism village is a community-based tourism which offers a rural tourism experience. The research was carried out in the context of strategy formulation post-COVID-19 pandemic. The research specifically portrays the shifting paradigm from quantity to quality tourism development which takes place partly in response to the pandemic. There are concepts and theories taken from the marketing and human resource management, that is, the branding concept, the Theory of Reasoned Action, and the commitment theory to enrich tourism study. The research is quantitative-causal research. This study selected the research locus in the three tourism villages in the Special Region of Yogyakarta, Indonesia. Data was collected through a survey. Data were analyzed using Structural Equation Modelling. The results of this study show that: 1) Level of awareness, Perceived importance, and Influence of other stakeholders positively affect commitment. 2) Level of awareness and Perceived importance positively affect Resource allocation, 3) Influence of other stakeholders has no effect on Resource allocation, and 4) Commitment positively affects Resource allocation. The research results lead to strategies for managing community-based tourism destinations to offer a quality tourism experience.
Systematic KMTNet Planetary Anomaly Search. XI. Complete Sample of 2016 Subprime Field Planets
Authors: Shin In-Gu , Yee Jennifer C. , Zang Weicheng , Han Cheongho , Yang Hongjing , Gould Andrew , Lee Chung-Uk , Udalski Andrzej , Sumi Takahiro ,   Leading authors, Albrow Michael D. , Chung Sun-Ju , Hwang Kyu-Ha , Jung Youn Kil , Ryu Yoon-Hyun , Shvartzvald Yossi , Cha Sang-Mok , Kim Dong-Jin , Kim Hyoun-Woo , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. ,   The KMTNet Collaboration, Mróz Przemek , Szymański Michał K. , Skowron Jan , Poleski Radosław , Soszyński Igor , Pietrukowicz Paweł , Kozłowski Szymon , Rybicki Krzysztof A. , Iwanek Patryk , Ulaczyk Krzysztof , Wrona Marcin , Gromadzki Mariusz ,   The OGLE Collaboration, Abe Fumio , Bando Ken , Barry Richard , Bennett David P. , Bhattacharya Aparna , Bond Ian A. , Fujii Hirosane , Fukui Akihiko , Hamada Ryusei , Hamada Shunya , Hamasaki Naoto , Hirao Yuki , Ishitani Silva Stela , Itow Yoshitaka , Kirikawa Rintaro , Koshimoto Naoki , Matsubara Yutaka , Miyazaki Shota , Muraki Yasushi , Nagai Tutumi , Nunota Kansuke , Olmschenk Greg , Ranc Clément , Rattenbury Nicholas J. , Satoh Yuki , Suzuki Daisuke , Tomoyoshi Mio , Tristram Paul. J. , Vandorou Aikaterini , Yama Hibiki , Yamashita Kansuke ,   The MOA Collaboration
Published: May 2024

Abstract
Following Shin et al. (2023b), which is a part of the “Systematic KMTNet Planetary Anomaly Search” series (i.e., a search for planets in the 2016 KMTNet prime fields), we conduct a systematic search of the 2016 KMTNet subprime fields using a semi-machine-based algorithm to identify hidden anomalous events missed by the conventional by-eye search. We find four new planets and seven planet candidates that were buried in the KMTNet archive. The new planets are OGLE-2016-BLG-1598Lb, OGLE-2016-BLG-1800Lb, MOA-2016-BLG-526Lb, and KMT-2016-BLG-2321Lb, which show typical properties of microlensing planets, i.e., giant planets orbit M-dwarf host stars beyond their snow lines. For the planet candidates, we find planet/binary or 2L1S/1L2S degeneracies, which are an obstacle to firmly claiming planet detections. By combining the results of Shin et al. (2023b) and this work, we find a total of nine hidden planets, which is about half the number of planets discovered by eye in 2016. With this work, we have met the goal of the systematic search series for 2016, which is to build a complete microlensing planet sample. We also show that our systematic searches significantly contribute to completing the planet sample, especially for planet/host mass ratios smaller than 10−3, which were incomplete in previous by-eye searches of the KMTNet archive.
Interaction between a Coronal Mass Ejection and Comet 67P/Churyumov–Gerasimenko
Authors: Huang Zhenguang , Tóth Gábor , Gombosi Tamas I. , Combi Michael R. , Jia Xianzhe , Shou Yinsi , Tenishev Valeriy , Altwegg Kathrin , Rubin Martin 
Published: May 2024

Abstract
The interaction between a coronal mass ejection (CME) and a comet has been observed several times by in situ observations from the Rosetta Plasma Consortium, which is designed to investigate the cometary magnetosphere of comet 67P/Churyumov–Gerasimenko (CG). Goetz et al. reported a magnetic field of up to 300 nT measured in the inner coma, which is among the largest interplanetary magnetic fields observed in the solar system. They suggested the large magnetic field observations in the inner coma come from magnetic field pileup regions, which are generated by the interaction between a CME and/or corotating interaction region and the cometary magnetosphere. However, the detailed interaction between a CME and the cometary magnetosphere of comet CG in the inner coma has not been investigated by numerical simulations yet. In this paper, we will use a numerical model to simulate the interaction between comet CG and a Halloween class CME and investigate its magnetospheric response to the CME. We find that the plasma structures change significantly during the CME event, and the maximum value of the magnetic field strength is more than 500 nT close to the nucleus. Virtual satellites at similar distances as Rosetta show that the magnetic field strength can be as large as 250 nT, which is slightly less than what Goetz et al. reported.
Outer Retinal Tubulation in Geographic Atrophy
Authors: Hatcher Kensington A. , Shah Birva K. , Burch Mark , Kondapalli Srinivas Sai A. , Baumal Caroline R. 
Published: May 2024

Background and Objective:
Outer retinal tubulation (ORT) is observed on optical coherence tomography images from patients with geographic atrophy (GA), but its clinical implications are unclear. The objective of this study was to investigate the prevalence of ORT and its association with GA lesion growth rates.

Materials and Methods:
This post hoc longitudinal analysis assessed 62 eyes randomized to sham treatment in the phase 2 FILLY trial. ORT prevalence was estimated at baseline, month 12, and month 18 and change in GA lesion growth from baseline to month 18 was calculated.

Results:
ORT prevalence rates were 24%, 43%, and 43% at baseline, month 12, and month 18, respectively. Slower mean GA lesion growth was observed in eyes with ORT present at baseline in the overall population as well as the subfoveal and nonsubfoveal GA subgroups.

Conclusion:
ORT presence may indicate a slower-growing GA lesion phenotype, independent of foveal involvement.

[
Ophthalmic Surg Lasers Imaging Retina
2024;55:448–451.]
Dystonia gravidarum
Authors: Lenka Abhishek , Prashanth L. K. 
Published: May 2024

Objectives:
To highlight the clinical significance of de novo dystonia and its spontaneous resolution during pregnancy.

Methods:
Two patients were evaluated in a movement disorder clinic during their first trimester of pregnancy and followed up longitudinally.

Results:
Our first patient developed severe right torticollis and laterocollis during the sixth week of pregnancy. No etiology could be identified by a series of laboratory and imaging investigations for dystonia. The patient had near-complete resolution of cervical dystonia, without any therapeutic interventions. The second patient developed cervical dystonia and severe neck spasms during the eighth week of pregnancy, and no identifiable etiologies were found. Because of the extreme severity of dystonia, the patient had to undergo medical termination of pregnancy, after which the dystonia subsided.

Discussion:
The literature on de novo dystonia in pregnancy or “dystonia gravidarum” is limited. To date, only three such cases have been reported. Our report expands the literature on this rare phenomenon. The cases in our study highlight that new movement disorders during pregnancy may indicate aberrant dopamine receptor sensitivity in a hyperestrogenic environment and that they are often self-limiting.
Analysis of dysgraphia in advanced Parkinson’s disease patients following bilateral STN-DBS
Authors: Kolpakwar Swapnil , Alugolu Rajesh , Mudumba Vijaya Saradhi , Kandadai Rukmini , Borgohain Rupam 
Published: May 2024

BACKGROUND:
Parkinson’s disease (PD) is characterized by varying intensities of bradykinesia, rigidity, and tremor leading to disturbances in writing skills of the patient. We undertook this study to evaluate dysgraphia features in advanced PD cases and changes in these features after bilateral subthalamic nucleus deep brain stimulation (DBS).

METHODS:
All idiopathic PD cases who underwent DBS at our center were included in this study. Patients were assessed preoperatively for dysgraphia by analysis of handwriting in “off” phase by a single investigator on bedside testing. For quantification of micrographia, vertical length of first letter and width of the word written were calculated. An analysis of legibility of handwriting was also done for all patients using Fahn-Tolosa-Marin Tremor Rating Scale (FTMTRS). Patients were analyzed for dysgraphia at 6 months post-surgery in drug ‘off’ phase, and outcomes were correlated with baseline parameters.

RESULTS:
There were a total of 51 patients who were included in our study. Significant reduction was noted in postoperative Unified Parkinson’s Disease Rating Scale part III (UPDRS III) scores (P = 0.0001). Age more than 65 years was associated with less improvement in FTMTRS grades. Prevalence of micrographia reduced in the postoperative period, but the difference was not statistically significant. Median FTMTRS grade in preoperative and postoperative “off” phase was 3 and 2, respectively. Difference in pre- and postsurgery FTMTRS grades was found to be statistically significant (P = 0.00001).

CONCLUSION:
Subthalamic nucleus DBS results in substantial improvement in legibility of handwriting of patients, particularly in cases with age less than 65 years.
Quantitative gait analysis in patients with spinocerebellar ataxia—An explorative analysis
Authors: James Tittu Thomas , SelvaGanapathy V. , Kamble Nitish , Dhargave Pradnya , Pal Pramod K. , Muralidharan Kesavan 
Published: May 2024

BACKGROUND:
Quantitative gait analysis is aimed at quantifying the degree of gait impairment in a patient. It helps to estimate the severity, track the prognosis, and identify the treatment effect in patients. There is a paucity of studies assessing gait characteristics in patients with spinocerebellar ataxia (SCA) using instrumental gait analysis. Here, we aim to identify the gait characteristics in patients with SCA and compare them with age-matched healthy individuals.

METHODS:
In this retrospective cross-sectional study, we analyzed the gait analysis data of patients with SCA from May 2018 to January 2020 in the gait and balance laboratory of the Physiotherapy Center in NIMHANS and compared them with age-matched controls from the existing database. The data were analyzed using an independent t-test.

RESULTS:
Each group consisted of 49 subjects. The SCA group had a mean age of 37.88 ± 13.25 years and the control group has a mean age of 40.88 ± 14.57 years, with a male to female ratio of 1:0.96 and 5:2, respectively. A significant difference was observed in all gait parameters (p < 0.001) between the SCA and control groups, except for swing time (p = 0.396). The SCA group demonstrated reduced velocity and cadence compared to the control group. The values of spatial parameters were reduced in the SCA group, with increased temporal parameters along with the base of support. The coefficient of variation was significantly increased in the SCA group, and the highest value was recorded for step length (10.45 ± 7.14).

CONCLUSION:
Patients with SCA demonstrated significant deviation in gait parameters from the normal values. The increased step-to-step variability in this patient population suggests an increased risk of falls. Identifying the changes in gait parameters at an early stage may help in planning the rehabilitation of patients with SCA, with focus on fall prevention strategies by targeting improvements in gait variability.
Learning from negative consequences is impaired by STN-DBS and levodopa in Parkinson’s disease
Authors: Raina Abhinav , Rajan Roopa , Sarma Gangadhara , Krishnan Syam , Kesavapisharady Krishnakumar , Kishore Asha 
Published: May 2024

CONTEXT:
Subthalamic nucleus deep brain stimulation (STN-DBS) and levodopa therapy are reported to produce impulsivity in PD. We tested the hypothesis that STN-DBS enhances impulsive decision-making and that this effect is masked by the beneficial influence of the concomitant reduction in levodopa therapy.

AIMS:
To compare learning from negative consequences in patients with PD receiving STN-DBS to those without surgery.

SETTINGS AND DESIGN:
We conducted a prospective study in the Movement Disorder Clinic of a tertiary care university hospital in India, recruiting 26 PD patients treated with STN-DBS (PD-DBS) and 25 matched control patients on medical therapy (PD-MED) alone.

METHODS:
Impulsivity and decision-making were assessed using the Iowa Gambling Task (IGT) at baseline and 3 months. Dopamine agonist dose was unchanged during the study period. IGT total and block scores were used to assess impulsive decision-making and task learning.

STATISTICAL ANALYSIS:
General linear mixed model involving repeated measures ANOVA was used to compare IGT total and block scores.

RESULTS:
There was no independent effect of STN-DBS on the IGT total score (P = 0.198). In the PD-DBS group, block scores worsened after surgery with a negative slope across blocks, suggesting a lack of task learning [TIME*BLOCK*INTERVENTION [F (4, 46) = 4.810, P = 0.003, partial Eta-squared = 0.095]. In the PD-MED group, block scores were seen to improve from baseline and across the blocks. These contrasting effects remained robust when tested in the Drug ON or OFF states. In the PD-DBS group, better task learning and higher block 5 scores were associated with greater post-operative reductions in total LEDD [TIME*BLOCK*LEDD [F (4, 46) = 3.818, P = 0.012, partial Eta-squared = 0.077].

CONCLUSIONS:
STN-DBS did not independently affect a global measure of decision making. However, STN-DBS and dopaminergic medications were shown to exert subtle yet significant opposing effects on the ability to learn from negative consequences.