bluuebunny/crossref_metadata_2025_split huggingface dataset:
Televisit with TytoHome™ device in medically complex child in long-term mechanical ventilation: a pilot study
Authors: Onofri Alessandro , Ullmann Nicola , Verrillo Elisabetta , Paglietti Maria Giovanna , Pavone Martino , Cutrera Renato 
Published: February 2025

Abstract

Background
During the pandemic, the pneumology team at Bambino Gesù Children’s Hospital highlighted that telemedicine was a valuable tool for remotely managing the medical needs of children with medical complexity (CMC). Following the telemedicine experience during the emergency phase, a telemedicine service was established, and new tools were tested to optimize televisits and the overall eHealth approach for patients. In this context, the TytoHome™ device was tested for performing objective examinations remotely. This pilot study, conducted at our hospital, explored the management of CMC patients on long-term mechanical ventilation via the telemedicine platform and the TytoHome™ device.

Methods
This study involved the treatment of 10 pediatric patients over one year using this approach. The patients were already receiving care at our hospital and were undergoing long-term mechanical ventilation (LTV) at home—4 on invasive mechanical ventilation (IMV) and 6 on non-invasive ventilation (NIV). A database was developed to collect patient data, including personal details, vital parameters, objective examinations, audio quality, and patient satisfaction. A descriptive analysis was subsequently performed using the data collected during the earlier stages of the study.

Results
The utility of the TytoCare device for medically complex children was evaluated. The families were “satisfied” with the remote follow-up visits, and healthcare personnel rated the audio quality of the visits as “good.”

Conclusions
In conclusion, the remote management of these patients using the Tyto device offered several advantages. In our experience, Tyto proved to be a useful tool for the remote medical management of complex patients.
A review of filarial nematodes parasitizing tick vectors: unraveling global patterns in species diversity, host associations, and interactions with tick-borne pathogens
Authors: Ajileye Oluwaseun D. , Verocai Guilherme G. , Light Jessica E. 
Published: February 2025

Abstract
Ticks are well-known vectors of pathogens, including filarial nematodes, which can affect animal and human health. This review synthesizes current knowledge of filarial nematodes that utilize ticks as vectors, focusing on the Onchocercidae. Five genera of onchocercid filarial nematodes (Cercopithifilaria, Cherylia, Cruorifilaria, Monanema, and Yatesia) have demonstrated vector–parasite relationships with ticks, while Acanthocheilonema has only demonstrated molecular detection without confirmed vector competence. Vector competence has been experimentally proven for several species through documented development to infective stages. However, our understanding of tick-borne filarial nematodes remains limited owing to insufficient detection efforts and methodological challenges. Detection methods include traditional dissection, advanced imaging techniques such as microcomputed tomography (micro-CT), and molecular approaches, each with distinct advantages and limitations. To address knowledge gaps, future research should focus on conducting large-scale surveys of tick populations and wildlife to investigate vector competence, health impacts, and coinfection dynamics. Multi-disciplinary collaboration and community involvement in tick surveillance will advance our understanding of tick-borne filarial nematode ecology and epidemiology. Future research priorities include confirming vector competence where only molecular detection exists, investigating natural transmission patterns, and understanding the mechanisms influencing successful development in tick vectors. By addressing these knowledge gaps through systematic surveillance and experimental studies, we can better understand these complex host–parasite–vector relationships and their implications for animal health.

Graphical Abstract
Screening and management of hospital hyperglycemia in non-critical patients: a position statement from the Brazilian Diabetes Society (SBD)
Authors: Marino Emerson Cestari , Momesso Denise , Toyoshima Marcos Tadashi Kakitani , de Almeida Maria Fernanda Ozorio , Schaan Beatriz D. , Negretto Leandra Anália Freitas , Santomauro Junior Augusto Cezar , Cukier Priscilla , Genestreti Paulo Roberto Rizzo , Feitosa Alina Coutinho Rodrigues , da Silva Soares Pinto Jorge Eduardo , Ribeiro Rogerio Silicani , Lamounier Rodrigo Nunes , Lyra Ruy , Bertoluci Marcello Casaccia 
Published: February 2025

Abstract

Background
Hospital Hyperglycemia (HH) is linked to poorer outcomes, including higher mortality rates, increased ICU admissions, and extended hospital stays, and occurs in both people living with diabetes or not. The prevalence of HH in non-critical patients ranges from 22 to 46%. This panel reviewed the evidence and made recommendations for the best care for hospitalized hyperglycemic patients, with or without diabetes mellitus.

Methods
The methodology was published previously and was defined by the internal institutional steering committee. The SBD Acute and Hospital Complications Department drafted the manuscript, selecting key clinical questions for a narrative review using MEDLINE via PubMed. The best available evidence was reviewed, including randomized clinical trials (RCTs), meta-analyses, and high-quality observational studies related to Hospital Hyperglycemia.

Results and conclusions
The department members and external experts developed 23 recommendations for the management of patients with HH, including screening, initial interventions, treatment adjustments, and care for potential complications. Based on the best available evidence, our article provides safe and effective management strategies for both public and private healthcare settings.
Food oral immunotherapy
Authors: McHenry Mary , Bégin Philippe , Chan Edmond S. , Latrous Meriem , Kim Harold 
Published: February 2025

Abstract
Food oral immunotherapy (OIT) is an option for the treatment of immunoglobin E (IgE)‐mediated food allergy that involves administering gradually increasing doses of an allergenic food over time (under medical supervision) with the goal of desensitizing an individual to the food allergen. Current Canadian clinical practice guidelines for OIT recommend this form of therapy as an option in patients with food allergy. The intervention should be prioritized in the infant and toddler population, in which it is particularly well tolerated and can lead to sustained unresponsiveness (also sometimes referred to as remission). In this article, we provide an overview of OIT and discuss the role non-allergist clinicians can play in caring for patients undergoing OIT.
Protocol for a single-arm feasibility trial of virtual family-centered rounds: increasing opportunities for family engagement among caregivers with language preference other than English
Authors: Hoyt-Austin Adrienne E. , Zerda Erika N. , Tancredi Daniel J. , Marcin James P. , Ketchersid Audriana , Horath Elva T. , Bushong Trevor R. , Merriott Daniel S. , Romano Patrick S. , Hoffman Kristin R. , Rosenthal Jennifer L. 
Published: February 2025

Abstract

Background
Telehealth use during family-centered rounds in the neonatal intensive care unit has been shown to shorten length of hospitalization and improve breastfeeding outcomes. For families who speak languages other than English, access to and use of telehealth technologies can be impeded by lack of interpreter services. We aim to evaluate the feasibility of telehealth use during family-centered rounds in the neonatal intensive care unit for families who speak languages other than English.

Methods
In this study proposal, we will conduct an intervention evaluation using the RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework to assess the feasibility of telehealth use during family-centered rounds among families who speak languages other than English in a single-arm feasibility trial. We will provide language-appropriate materials to assist parents with accessing the telehealth technology and bring interpreters into the telehealth encounter directly with neonatal providers. All eligible infants whose families speak languages other than English in a single-site level 4 neonatal intensive care unit during the study period will be included. These families can participate in hospital rounds via telehealth, in-person, or not participate in hospital rounds. We will examine feasibility objectives that assess parental uptake of telehealth for rounds, parental participation in rounds, presence of a certified medical interpreter, telehealth technical issues, and parental survey response rates. We will conduct a mixed methods implementation evaluation using the RE-AIM framework. Exploratory outcomes include parent attendance, length of hospitalization of the infant, human milk feeding, frequency of medical error, parent-reported experience, parental comfort with their child’s care, and parental quality of life will be collected.

Discussion
This study will aid in understanding gaps to telehealth care in languages other than English. We believe this approach will improve health outcomes for hospitalized premature infants, understanding of medical conditions, improve parental quality of life, and reduce inequities in access to healthcare via telehealth technologies.

Trial registration
NCT05917899 Limited English Proficiency Virtual Family-Centered Rounds, first posted June 26, 2023, last update posted November 11, 2024.
Susceptibility of Anopheles gambiae s.l. to the neonicotinoid insecticide clothianidin in eighteen sites located along the south–north transect of Benin
Authors: Hougbe Steve Zinsou , Sovi Arthur , Koumodji Koffi , Ahouandjinou Minassou Juvénal , Affolabi Zul-kifl , Towakinou Linda , Chitou Saïd , Agbo-Ola Andil , Tokponnon Filémon , Zoungbédji David Mahouton , Sagbohan Hermann , Kpanou Casimir , Padonou Germain Gil , Baba-Moussa Lamine , Ossé Razaki A. 
Published: February 2025

Abstract

Background
The widespread resistance of malaria vectors to traditional neurotoxic insecticides has stimulated the search for new insecticide classes with novel modes of action. For that, the present study was designed to collect data on the susceptibility of field-collected Anopheles gambiae sensu lato (s.l.) to clothianidin, a neonicotinoid insecticide used in agriculture and that recently received WHO approval for use in indoor residual spraying.

Methods

An. gambiae s.l. were collected as larvae and pupae from 18 sites located along the south–north transect of Benin, and reared to adulthood. Female mosquitoes aged 2–5 days were exposed to clothianidin-impregnated papers (2% weight by volume (w/v) of SumiShield™ 50WG dissolved in distilled water). Due to the delayed action of clothianidin, mortality was daily recorded over 7 days. Polymerase chain reaction was used to assess the molecular species composition in the An. gambiae s.l. complex and the frequency of knockdown resistance (kdr) and insensitive acetylcholinesterase (Ace-1

R
) mutations.

Results
Mortality rates of field-collected An. gambiae s.l. were very high (≥98%) between 2- and 7-day post-exposure, indicating full susceptibility to clothianidin. Molecular species identification revealed the presence of An. coluzzii (53.7%), An. gambiae sensu stricto (s.s.) (42.5%), and An. arabiensis (3.8%) in the An. gambiae s.l. complex. kdr and Ace-1

R
mean frequencies were 84% (95% CI 82–86) and 3% (95% CI 2–4) in An. coluzzii, and 88% (95% CI 87–90) and 4% (95% CI 3–6) in An. gambiae s.s., respectively.

Conclusions
Findings of the present study indicates that An. gambiae s.l. populations collected along the north–south transect of Benin remain susceptible to clothianidin. This broadens the portfolio of indoor residual spraying products that the national malaria control programme can deploy to better control pyrethroid-resistant populations of vectors.
Praziquantel plasma concentration and its metabolic ratio suboptimally predict schistosomiasis cure among infected children
Authors: Mnkugwe Rajabu Hussein 
Published: February 2025

Abstract

Background
In recent years, biomarkers or surrogate endpoints have been shown to be vital in predicting treatment response. In schistosomiasis treatment using praziquantel, it has been suggested that drug level quantified at 4 hours post drug intake is an optimal sampling time for monitoring of its systemic exposure. However, no studies have established whether it is the parent drug plasma concentration or its major metabolic ratio which better predict treatment outcome. In addition, the cutoff threshold values for these biomarkers in predicting cure have not been studied.

Results
A total of 287 participants were enrolled and followed up for 21 days. The median age of the study population was 12 years (range 7–16 years). The cutoff point for praziquantel concentration in predicting schistosomiasis cure was ≥ 222 ng/dL (Youden’s index = 0.341, AUC = 0.688), while for metabolic ratio was ≥ 0.038 ng/dL (Youden’s index = 0.276, AUC = 0.661). Praziquantel plasma concentration had a sensitivity of 63% (95% CI 56.5–69.2%), specificity of 71.2% (95% CI 56.9–82.9%) and diagnostic accuracy of 64.5% (95% CI 58.6–70.0%). While the positive and negative predictive values (PPV and NPV) were 90.8% (95% CI 83.5–94.8%) and 29.8% (95% CI 22.0–38.7%), respectively. The AUC for praziquantel plasma concentration was found to be 68.8% (95% CI 61.0–76.6%) (p < 0.001). Metabolic ratio had a sensitivity of 46.8% (95% CI 40.3–53.4%), specificity of 80.8% (95% CI 67.5–90.4%) and diagnostic accuracy of 53% (95% CI 47.0–58.9%). While the PPV and NPV were 91.7% (95% CI 85.2–95.9%) and 25.2% (95% CI 18.8–32.4%), respectively. The AUC for metabolic ratio was found to be 66.1% (95% CI 58.4–73.8%) (p = 0.0003). There was no statistically significant difference in the discriminatory power of praziquantel plasma concentration (AUC = 68.8%) and metabolic ratio (AUC = 66.1%) in predicting schistosomiasis cure (p = 0.25).

Conclusion
Despite praziquantel plasma concentration having significantly higher sensitivity and negative predictive value than the metabolic ratio, both biomarkers suboptimally predicted schistosomiasis cure at 21 days follow-up.
BIG: a framework integrating brain-inspired geometry cell for long-range exploration and navigation
Authors: Sun Zhen , Ma Kehui , Xia Songpengcheng , Wu Qi , Xiong Chaoran , Xiang Yan , Pei Ling 
Published: February 2025

Abstract
Recently, the brain-inspired mechanisms beneficial to efficient navigation in mammals have exhibited huge research potential. Specifically, the geometry cell model has shown significant insights into the ability of mammals, which is used to model the geometric information of their surroundings during movement. Meanwhile, the process of general exploration will consume large amounts of computing resources when agents with high-performance computing equipment accomplish autonomous tasks. This paper focuses on the long-range autonomous exploration and navigation tasks in which they are conducted by agents within complex indoor and outdoor environments. To reduce the computational demands, we propose a framework integrating the Brain-Inspired Geometry-awareness namely BIG for two autonomous tasks. The exploration task named BIG-Explorer involves efficiently searching untouched areas by embedding the geometry cell model. It identifies expanding frontiers using geometric assigners and takes into account relevant factors such as boundary information. The navigation task named BIG-Navigator builds upon insights gained during the exploration phase and guides agents to a predefined destination. We conduct comprehensive experimental assessments within third-party simulation environments. The evaluation metrics employed in this paper include the number of nodes, the length of a path, algorithm execution time, and the size of exploration space. Finally, the results of the evaluation demonstrate that the incorporation of geometry cell model increases the efficiency in both exploration and navigation processes by at least

$$20\%$$

20
%

, compared with four benchmark methods.
Exploring the effects of hemodialyzers on clinical outcomes in pediatric cardiac surgery during cardiopulmonary bypass: a retrospective cohort study
Authors: Abdelazim Ahmed M. , Amer Akram M. , Elsobky Yasmin , Shelbaya Khaled , Fadaly Ahmed S. 
Published: February 2025

Abstract

Background
Hemofiltration during and after cardiopulmonary bypass (CPB) reduces levels of proinflammatory cytokines and total interstitial body water. Because of economic causes, hemofilters became less available in low- and middle-income countries, which forced the perfusionists to use hemodialyzers instead. This study aimed to assess the clinical outcomes of pediatric patients who had hemodialyzers instead of hemofilters during CPB. We performed a retrospective cohort study of 46 pediatric patients who underwent cardiac surgery between January 1st, 2023, and September 30th, 2023. Patients included were those who required hemofiltration during CPB.

Results
The median age and weight were 0.95 years [0.28, 2.76] and 7.5 kg [5.2, 13.6], respectively. Tetralogy of Fallot repair represented 24% of cases. CPB and aorta cross-clamp times averaged 93.0 ± 32.6 min and 60.1 ± 24.2 min, respectively. The overall mortality rate was 6.5% (n = 3). Among the deceased, all had RACHS-1 (Risk Adjustment in Congenital Heart Surgery) score 4. Mortality in the deceased group was linked to several significant factors compared to the survivors, including, lower CPB temperature (28 °C vs. 32 °C), higher lactate levels (2.9 ± 0.9 vs. 1.9 ± 0.7 mmol/L), longer mechanical ventilation duration (288 vs. 21 h), and prolonged Intensive Care Unit stay (12 vs. 3 days). CPB time, aorta cross-clamp time, or post-CPB hematocrit did not significantly differ between survived and deceased patients.

Conclusions
In this retrospective analysis of 46 pediatric patients, the use of hemodialyzers for hemofiltration during CPB could be safe with acceptable mortality rate. While these preliminary findings are promising, the sample size and retrospective design limit generalizability. Further prospective studies with larger cohorts are warranted to more effectively evaluate the safety and efficacy of hemodialyzers as an alternative to hemofilters.
Investigation of multiple-vehicle scenarios to improve system identification for indirect health monitoring of bridge networks
Authors: Abuodeh Omar , Redmond Laura 
Published: February 2025

Abstract
Vibration data from passing vehicles can theoretically be leveraged for indirect health monitoring (IHM) of bridges. However, vibration data collected from vehicles on bridges are often tainted with noise, including vehicle harmonics, road conditions, and environmental factors. Researchers employ system identification (SI) techniques to extract pertinent bridge features from this noisy data yet face limitations due to user-defined parameters and validation with sparse datasets. This study leverages supercomputing and an automated postprocessing framework to identify testing protocols and vehicle parameters that enhance SI across the bridge network using Vehicle-Bridge Interaction (VBI) models. Vehicle properties for four vehicle classes are gathered from literature, while six bridge properties are derived from tested bridges and department of transportation records. Findings reveal that heavier and faster leading vehicles facilitate bridge frequency extraction. Challenges such as masking of bridge frequencies by road roughness and low-pass effects of vehicle suspension on bridges with higher natural frequencies are identified. Solutions include employing faster trailing vehicle speeds shift the road roughness frequency bands away from the bridge’s frequency and using heavier leading vehicles to enhance bridge response. In addition, an advanced signal processing technique, autonomous peak picking variational mode decomposition (APPVMD), successfully extracts bridge frequencies for problematic bridges.
Therapeutic Potential of 1,8-Cineole in Respiratory Diseases with a Focus on Asthma, Sinusitis, and Upper Respiratory Tract Infections: A Comprehensive Review
Authors: Hermanowicz Kamil , Oleksy Daria , Doman Katarzyna , Nowak Julia , Cioch Michał Jakub , Najdek Agnieszka , Komada Dawid , Kaczmarska Urszula , Woźniak Aleksandra , Mycyk Marcin 
Published: February 2025

IntroductionRespiratory diseases, such as chronic sinusitis, asthma, and URTIs, are among the leading global health burdens, affecting tens of millions of people every year. These conditions often involve chronic inflammation, impaired mucociliary function, and obstruction of the airways, leading to deteriorating respiratory health.
The natural compound 1,8-cineole is a monoterpene present in eucalyptus oil and has received attention in recent times as an alternative therapeutic agent for respiratory diseases. Its anti-inflammatory, antioxidant, mucolytic, bronchodilatory, antiviral, and antimicrobial effects may be beneficial in the management of these diseases. Clinical evidence has shown that 1,8-cineole provides symptom relief, improves lung function, and enhances quality of life, particularly in patients with COPD, asthma, and chronic sinusitis. Besides, due to its good safety profile and minimal side effects, it represents a very attractive adjunctive treatment option.
MethodsThis review synthesizes both classic and contemporary research findings on the mechanisms of action, clinical efficacy, and safety profile of 1,8-cineole. A comprehensive literature search was conducted across peer-reviewed journals to provide a balanced and evidence-based overview.
ResultsEvidence indicates that 1,8-cineole effectively modulates inflammatory pathways by inhibiting cytokine release and suppressing arachidonic acid metabolism. Clinical trials demonstrate its efficacy in reducing symptoms of chronic sinusitis, improving pulmonary function in asthma, and alleviating symptoms in URTIs. Safety data support its tolerability, with mild gastrointestinal discomfort reported in rare cases.
Conclusion1,8-Cineole represents a promising alternative or adjunctive treatment for inflammatory respiratory conditions. Future research should focus on optimizing delivery methods and investigating its synergistic potential with existing therapies.