bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquired growth hormone deficiency in a girl with chronic myelogenous leukemia treated with tyrosine kinase inhibitor therapy
Authors: Hobernicht Susan L. , Schweiger Bahareh , Zeitler Philip , Wang Michael , Hunger Stephen P. 
Published: December 2010

AbstractChronic myelogenous leukemia (CML) is caused by the BCR‐ABL1 fusion gene that encodes for a constitutively‐active tyrosine kinase. Adults and children with CML are typically treated with imatinib mesylate, a BCR‐ABL1 tyrosine kinase inhibitor (TKI), or a second‐generation TKI. Several case reports have documented growth delay of unknown mechanism in children with CML treated with imatinib. We report a seven‐year‐old identical twin with CML who developed significant growth delay, as compared to her twin, during five years of TKI therapy. Detailed endocrine evaluation showed acquired growth hormone deficiency, a pathway potentially inhibited by TKIs. Pediatr Blood Cancer 2011;56:671–673. © 2010 Wiley‐Liss, Inc.
Treatment efficiency, outcome and surgical treatment problems in patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma: A report from the cooperative soft tissue sarcoma trial CWS‐96
Authors: Seitz Guido , Dantonello Tobias M. , Int‐Veen Christoph , Blumenstock Gunnar , Godzinski Jan , Klingebiel Thomas , Schuck Andreas , Leuschner Ivo , Koscielniak Ewa , Fuchs Jörg ,   on behalf of the CWS‐96 Study Group
Published: December 2010

AbstractBackgroundTo analyze the clinical course, treatment modalities, complications and outcome of patients suffering from localized embryonal bladder/prostate rhabdomyosarcoma (BPRMS) treated on the CWS‐96 trial.ProcedureThere were 85 patients with BPRMS enrolled and 63 patients with embryonal non‐metastatic BPRMS were analyzed. Fifty‐six patients received neoadjuvant chemotherapy and response was assessed radiographically after 9 weeks. Local therapy with radiation and or surgery was performed based on age, tumor size, and response. Patients were treated with adjuvant chemotherapy following local control.ResultsPatient's age ranged from 0 to 16 years with a median follow up of 5.3 years. Eighty nine percent of the patients had IRS group III disease. The 5‐year overall survival (OS) for the whole group was 76.3 ± 5.6% and the 5‐year event‐free survival (EFS) 69.8 ± 6.2%. Seventeen patients underwent preoperative radiochemotherapy followed by tumor resection (5‐year‐OS: 87.8 ± 8.1%). Eight patients were treated with solely radiochemotherapy (87.5 ± 11.7%). Twenty‐five patients received chemotherapy and tumor resection (OS: 83.6 ± 7.5%). Thirteen patients underwent incomplete tumor resection and were treated with radiochemotherapy postoperatively (OS: 39.9 ± 14.8%, P < 0.05 vs. other groups).ConclusionsLocal therapy is an important factor for prognosis of localized embryonal BPRMS. Inadequate primary or secondary surgery compromises the outcome and should be avoided. Radiotherapy alone, complete surgical tumor resection or combined preoperative radiotherapy with surgical resection lead to similar good local control rates and prognosis. Pediatr Blood Cancer 2011;56:718–724. © 2010 Wiley‐Liss, Inc.
Effect of transfusion therapy on transcranial doppler ultrasonography velocities in children with sickle cell disease
Authors: Kwiatkowski Janet L. , Yim Eunsil , Miller Scott , Adams Robert J. ,   for the STOP 2 Study Investigators
Published: December 2010

AbstractBackgroundChildren with sickle cell disease (SCD) and abnormal transcranial Doppler (TCD) ultrasonography have a high risk of stroke, but this risk is greatly reduced when chronic transfusion therapy is administered. The change in TCD velocities during chronic transfusion therapy and rate and frequency of normalization of TCD findings have not been studied extensively.ProceduresUsing data from children with SCD enrolled as potential subjects in the Optimizing Primary Stroke Prevention in Sickle Cell Anemia (STOP 2) trial, we characterized the change in TCD velocities on transfusion therapy and identified predictors of developing a normal TCD.ResultsAmong 88 children with serial TCD data after starting transfusions for abnormal TCD 46 (52%) converted to normal TCD after a mean of 4.3 months (median 3.0; range 0.85–14.3 months) of transfusions. TCD studies remained abnormal in 19/88 (21.6%) after a mean of 2.4 years of transfusion. The median TCD velocity was lowered by 38 cm/sec within 3 months of initiating transfusions, followed by a more gradual decline then stabilization of velocities, although with significant individual variation. Factors associated with conversion to normal TCD included lower initial TCD velocity, younger age, and higher pre‐transfusion hemoglobin level during transfusion therapy.ConclusionYounger children with higher pre‐transfusion hemoglobin levels and lower abnormal TCD velocities are most likely to have rapid normalization of TCD on transfusions. Long‐term follow‐up of children with persistently abnormal exams or worsening velocities on transfusion is needed to determine if these children are at higher risk of stroke. Pediatr Blood Cancer 2011;56:777–782. © 2010 Wiley‐Liss, Inc.
Impact of serum acetaminophen concentration on changes in serum potassium, creatinine and urea concentrations among patients with acetaminophen overdose
Authors: Zyoud Sa'ed H. , Awang Rahmat , Sulaiman Syed Azhar Syed , Al‐Jabi Samah W. 
Published: December 2010

AbstractBackgroundAcetaminophen overdose may be accompanied by electrolyte disturbances. The basis for electrolyte change appears to be due to increased fractional urinary electrolyte excretion.PurposeThis study investigated the impact of serum acetaminophen concentration on changes in serum potassium, creatinine and urea concentrations in patients with acetaminophen overdose.MethodsThis was a retrospective cohort study which included patients admitted to the emergency department and hospital within 24 h of acetaminophen ingestion. The study was conducted over a period of 5 years from 1 January 2004 to 31 December 2008. Data are presented as mean ± SD and as medians (interquartile range) and groups were compared using independent two‐tailed Student t‐test. Statistical Package for Social Sciences (SPSS) 15 was used for data analysis.ResultsTwo hundred and eighty‐three patients were studied (44 males and 239 females), mean age 23 ± 7.5 years. Patients who had a serum acetaminophen concentration above a ‘possible toxicity’ treatment line were associated with an elevation in serum creatinine concentration (p = 0.044) and a reduction in the serum potassium concentration (p < 0.001) but were not associated with a reduction in serum urea concentration (p > 0.99). During the study period, 63.3% (179 patients) had serum potassium concentrations less than the normal concentration (3.5 mmol/l) and 31.4% (89 patients) had serum urea concentrations less than the normal concentration (2.5 mmol/l). The serum creatinine concentration in all patients was within the normal range.ConclusionsAcetaminophen appears to cause a concentration‐dependent reduction of potassium concentrations and an elevation of creatinine concentrations of short duration (<24 h) after overdose. Copyright © 2010 John Wiley & Sons, Ltd.
Enhanced physician adherence to antibiotic use guidelines through increased availability of guidelines at the time of drug ordering in hospital setting
Authors: Westphal Jean‐Frederic , Jehl Francois , Javelot Herve , Nonnenmacher Cathy 
Published: December 2010

AbstractPurposeSome studies have shown that making practice guidelines accessible to physicians when they are making clinical decisions could improve prescribing practices. The aim of the study was to assess the benefit of impact on physician adherence of the intervention that consisted of embedding previously paper‐based antibiotic guidelines in the computerized physician drug order entry system of a teaching hospital in order to make these guidelines available to physician at the time of antibiotic ordering. Before the intervention, these guidelines were available in booklet form in all the wards of the hospital.MethodsAdherence to guidelines was evaluated in 471 consecutive antibiotic orders for pneumonia, 104 just before and 367 just after the intervention. The evaluation criteria were: the choice of the antibiotic relative to the context of acquisition of pneumonia, the daily dose, the planned duration of treatment. Evaluation of antibiotic orders was performed at the initiation of antibiotic treatment.ResultsThe intervention was followed by a significant decrease in the proportion of antibiotic orders containing at least one criterion of non‐conformity to the guidelines, respectively, 33% after vs. 51% (p < 0.001) before the intervention. Proportion of non‐conform orders decreased in the post‐ vs. pre‐intervention period for the daily dosage of antibiotics, respectively, 12.2% vs. 26.9% (p < 0.001), for the planned duration of treatment, respectively, 7.3% vs. 18.3% (p < 0.001), whereas for the choice of antibiotics relative to the context of acquisition of pneumonia, the improvement failed to reach statistical significance, respectively, 18.2% vs. 25% (p = 0.12).ConclusionIn this study, the increased availability of antibiotic guidelines at the time of drug ordering, combined with a periodical reinforcement educational round, was associated with an enhanced physician adherence to these guidelines. Copyright © 2010 John Wiley & Sons, Ltd.
Knowledge, attitudes and beliefs of Arabic‐Australians concerning cancer
Authors: Saleh Mona , Barlow‐Stewart Kristine , Meiser Bettina , Tucker Kathy , Eisenbruch Maurice , Kirk Judy 
Published: December 2010

AbstractObjectives: To explore with Arabic‐Australian patients and their communities, the cultural context of cancer, both sporadic and inherited, by examining their beliefs about its causes and the modes of communication about cancer with family, friends and the community.Method: The design is an ethnographic and qualitative interview study with thematic analysis. Arabic‐Australian participants were recruited in two stages. First, patients who had attended a family cancer clinic in Sydney, Australia, were invited to participate. Second, participants from the general community in Sydney were recruited with the aim of either verifying or challenging the reported findings from the clinic sample.Results: A total of 38 interviews with 26 females and 12 males provided cultural descriptions of illnesses, including cancer, and its causes. The terminologies around cancer and a cancer diagnosis were believed to have more impact and generate greater fear in people in the Arabic community living in Australia than the terms used to describe a diagnosis of other illnesses. Despite this, those interviewed were aware of screening and community programs and were open to discuss their views about cancer with the research team.Conclusion: Arabic‐Australians are an important group in the community with unique culture‐specific attributes that can affect communication about cancer in the clinical setting. Barriers to communication such as the negative feelings associated with the word cancer and the stigma it arouses must be acknowledged. Culturally competent clinical practices with this group include the incorporation of these belief systems into the communication process and avoidance of stereotyping. Copyright © 2010 John Wiley & Sons, Ltd.
Role of telehealth/videoconferencing in managing cancer pain in rural American Indian communities
Authors: Haozous Emily , Doorenbos Ardith Z. , Demiris George , Eaton Linda H. , Towle Cara , Kundu Anjana , Buchwald Dedra 
Published: December 2010

AbstractObjectives: This project is aimed at determining the feasibility and effect of using videoconferencing to deliver cancer‐related pain management education and case consultation to health care providers in rural AI/AN communities.Methods: The project provided four educational sessions and nine case conferences to health care providers at tribal clinics in Washington State and Alaska using videoconferencing with pain experts at the University of Washington. A cross‐sectional, descriptive study design was used to survey the participating providers. Measures included satisfaction with the telehealth system and self‐perceived competence in pain management.Results: Fifty‐two providers from 11 sites attended the educational sessions. Ninety‐three providers from 16 sites participated in the case conferences. Case conference participants scored significantly higher on perceived competence in treating pain compared with clinic providers who did not attend. Educational session participants and case conference participants both reported a high level of satisfaction with videoconferencing.Conclusions: Telehealth is a feasible and effective way to deliver cancer‐related pain management education and increase competence among rural health care providers. Copyright © 2010 John Wiley & Sons, Ltd.
Flutter valve improves respiratory mechanics and sputum production in patients with bronchiectasis
Authors: Figueiredo Pedro H. S. , Zin Walter A. , Guimarães Fernando S. 
Published: December 2010

AbstractBackground and Purpose. Although the application of airway clearance techniques is considered an important component in the treatment of several obstructive pulmonary diseases, there is no scientific evidence supporting the use of Flutter Valve™ in the management of patients with bronchiectasis. Moreover, the consequences of respiratory physiotherapy techniques on respiratory mechanics have not been fully studied. Therefore, we investigated the acute, short‐term effects of Flutter Valve™ on respiratory mechanics and sputum production in bronchiectatic patients. Methods. Eight patients were evaluated in a randomized, blinded, cross‐over trial. Impedance at 5 Hz (R5), resistance as a function of oscillation frequency (dR/dF), reactance at 5 Hz (X5), resonant frequency (f0) and integral of reactance between 5 Hz and resonant frequency (AX) were recorded. Results. Flutter Valve™ cleared 8.4 mL more secretions than the Sham Flutter intervention (95% confidence interval [95% CI], 3.4–13.4). There was a higher percentage decrease in R5 (−11.2%; 95% CI, −4.4 to −18.2), dR/dF (−20.8%; 95% CI, −32.4 to −9) and AX (−7.8%; 95% CI, −11.9 to −3.7) under Flutter Valve™. X5 and f0 variation did not differ between interventions. Conclusions. Flutter Valve™ increases sputum removal during treatment and diminishes total and peripheral airway resistance in hypersecretive patients with bronchiectasis. Impulse oscillometry is a user‐friendly tool to evaluate the effects of airway clearance techniques on respiratory mechanics. Copyright © 2010 John Wiley & Sons, Ltd.
Hot‐electron drift velocity and hot‐phonon decay in AlInN/AlN/GaN
Authors: Ardaravicˇius L. , Liberis J. , Kiprijanovicˇ O. , Matulionis A. , Wu M. , Morkoç H. 
Published: December 2010

AbstractA nanosecond‐pulsed current–voltage technique was applied to study hot‐electron transport along the two‐dimensional electron gas channel confined at a nominally undoped AlInN/AlN/GaN heterointerface. Hot‐electron drift velocity was deduced under the assumptions of uniform longitudinal electric field and field‐independent electron sheet density. At a fixed electric field strength, a resonance‐type non‐monotonous dependence of the velocity on the electron density was found in the investigated range from 1 to When the electric field increased from 20 kV/cm to 80 kV/cm, the peak velocity increased from ∼1.1 to cm/s, and the position of the resonance shifted from ∼1.1 to ∼1.2 respectively. The resonance position correlates with that for the fastest decay of hot phonons known from independent experiment. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Computation of the maximum torque of a cap liner using a power‐law friction and finite element analysis
Authors: Lajmi Abdelmajid , Champliaud Henri , Lê Van Ngan 
Published: December 2010

AbstractIn the ‘filled closed’ containers, the cap removal torque and the sealing of the contents are two crucial criteria in the closing quality, and the consumer perceives these two parameters as constituting a guarantee of packaging integrity. This work looks at the experimental study and the finite element analysis of the maximum torque of a metal cap with a liner over a glass bottle. For studying parameters influencing the cap removal torque (twist‐off torque), several experiments and simulations were conducted in order to evaluate the maximum torque of a loose crown cap. A test bench was built to measure the torque required to slide a cap liner on the top of a glass bottle, and the result of the experiment is compared with the predicted torque given by an axisymmetric finite element (FE) analysis. Since the behaviour of the cap liner is hyperelastic, compression and friction tests were conducted to evaluate the elastic properties and the non‐linear static friction behaviour of the elastomer seal. Contact regions, material non‐linear elasticity for the liner and large displacement options are included in the FE model in order to describe the evolution of the contact area and the distribution of contact pressure as a function of the applied force. The predicted maximum torque is then calculated by a numerical integration scheme over the contact surface, using an experimental coefficient of static friction as a function of the normal pressure. The predicted torque shows good agreement with that measured through experiments, thereby making it possible to understand the influence of the liner on the cap removal torque of a glass bottle. Copyright © 2010 John Wiley & Sons, Ltd.
Best management practices for environmental restoration programs
Authors: Gibbs James T. , Santillan Javier , Callier Mozella , Porter Ronald 
Published: December 2010

AbstractBased on a review of hundreds of environmental restoration program optimization reviews, this article describes management tools found in successful and efficient remediation programs. Projects that consistently struggled to achieve their objectives were observed to be missing certain, or to have inadequately used, these tools. The tools are articulated as best practices because when they are present and actively used, project shortcomings were minimal. Priority objectives for site owners and project managers include improving efficiency and effectiveness through performance management, reducing resource usage and energy consumption, ensuring protectiveness, and reducing uncertainty in management decision making.Restoring environmental resources damaged by historic waste management practices began in earnest in the late 1960s and early 1970s with the broad recognition of the problems caused by environmental discharges and spills when wastes are not managed appropriately. Under new regulations, soil and groundwater remediation projects could be, and were, conducted within a defined framework.The number and variety of restoration projects that were launched resulted in a slew of projects progressing through the stages of characterization, decision, and cleanup, and more were added to the cleanup process each year. In the 1990s, the Department of Defense noted that many cleanup efforts were projected to incur substantial operational, maintenance, and monitoring costs for decades into the future. This was correctly perceived as an opportunity to optimize those systems and programs, minimize costs, and reduce health and environmental risks. The best practices outlined in this article address management tools that were identified in optimization efforts that led to effective and efficient environmental remediation projects. © 2010 Wiley Periodicals, Inc.
Advanced site diagnostic tool 3D‐CSIA for in situ remediation
Authors: Wang Yi , Smith Gregory J. 
Published: December 2010

AbstractIn situ remediation is inherently considered “green remediation.” The mechanisms of destruction by in situ technologies, however, are often unseen and not well understood. Further, physical effects of amendment application affect concentration data in an identical manner as the desired reactive mechanism. These uncertainties have led to the weight‐of‐evidence approach when proving viability: multiple rounds of data collection, bench studies, pilot studies, and so on. Skipping these steps has resulted in many failed in situ applications. Traditional assessment data are often tangential to the desired information (e.g., “Is contaminant being destroyed or just being pushed around and diluted?” and “What is the mechanism of the destruction and can it be monitored directly?”). An advanced site diagnostic tool, “Three‐Dimensional Compound Specific Stable Isotope Analysis” (3D‐CSIA), can assess the viability of in situ technologies by providing definitive data on contaminant destruction that are not concentration‐related. The 3D‐CSIA tool can also locate source zones and apportion remediation cost by identifying plumes of different isotope signatures and fractionation trends. Further, use of the 3D‐CSIA tool allows remediation professionals to evaluate effectiveness of treatment and make better decisions to expedite site closure and minimize costs. This article outlines the fundamentals of advanced site diagnostic tool 3D‐CSIA in detail, and its benefit is highlighted through a series of case studies at chlorinated solvent–contaminated sites. © 2010 Wiley Periodicals, Inc.
Successful application of monitored natural attenuation in a surficial aquifer
Authors: Crouch Dylan , White Jay D. , Butler‐Veytia Belinda , Medler Robert 
Published: December 2010

AbstractGroundwater investigations conducted since 1988 at a Tennessee Department of Environment and Conservation (TDEC) Voluntary Oversight and Assistance Program (VOAP) site located in Millington, Tennessee, have defined the lateral and vertical extent of site chemicals of concern (COCs) consisting of tetrachloroethene (PCE), trichloroethene (TCE), and associated degradation products. Results of a groundwater remedial investigation determined that aquifer conditions were favorable for anaerobic degradation of COCs through reductive dechlorination. A subsequent groundwater feasibility study determined that monitored natural attenuation (MNA) coupled with long‐term groundwater monitoring was the most effective and suitable remedial option for the site. A Record of Decision was issued by the TDEC VOAP approving MNA and long‐term groundwater monitoring as the remedial option for the site, a first for such a site in Tennessee involving chlorinated organics. A groundwater fate and transport model (the 1998 model) developed during the RI was used as the basis for the MNA remedy. Analytical data from 1998 to 2008 indicate COCs in former high‐concentration areas continue to degrade at rates consistent with or ahead of the 1998 model predictions. Evidence of reductive dechlorination is also supported by the continued presence of breakdown products—specifically, vinyl chloride and ethene (terminal endpoint of PCE breakdown through reductive dechlorination). The continued detection of breakdown products along the flow‐path wells also confirms the effectiveness of the MNA remedy at the site. Current analytical data indicate that COC plumes beneath the site are not migrating and are actually retracting. © 2010 Wiley Periodicals, Inc.