bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Histopathologic Follow-up Findings With Vaginal Human Papillomavirus and Low-Grade Squamous Intraepithelial Lesion Papanicolaou Test Results
Authors: Bansal Mona , Austin R Marshall , Zhao Chengquan 
Published: December 2011

Context.—Data on high-risk human papillomavirus (hrHPV) DNA test results in vaginal, liquid-based cytology (LBC) specimens and corresponding cytologic and histopathologic correlation data are limited.Objective.—To analyze follow-up correlation data associated with vaginal (after hysterectomy) low-grade squamous intraepithelial lesion (LSIL) LBC and hrHPV test results.Design.—Hospital records were searched for vaginal LSIL LBC and hrHPV results between July 1, 2005, and July 30, 2009. Histopathologic and Papanicolaou test follow-up correlation data were analyzed.Results.—During the study period, 2892 patients with test results from both posthysterectomy vaginal LBC and hrHPV were identified: 148 (5.1%) of the patients had vaginal Papanicolaou test results reported as LSIL, with hrHPV detected in 113 of the 148 patients (76.4%). Of 148 patients, 59 of those with vaginal LSIL including 48 (81.4%) with positive HPV testing and 11 (18.6%) with negative HPV testing results had a follow-up vaginal biopsy. Histopathologic vaginal intraepithelial neoplasia (VAIN) 2/3 was diagnosed in 7 of 59 patients (11.9%) with biopsies. In all 7 patients who were diagnosed with VAIN 2/3, hrHPV was detected in the LBC vial. No VAIN 2/3 diagnoses were documented in the biopsy specimens from the 11 patients with hrHPV− LSIL Papanicolaou test results. Histopathologic VAIN 2/3 was diagnosed from vaginal biopsies in 7 of the 48 patients (14.6%) with vaginal hrHPV+ LSIL test results.Conclusions.—Sensitivity and specificity of hrHPV test results associated with histopathologic follow-up diagnoses of VAIN 2/3 in patients with vaginal LSIL results were 100% and 21.2%, respectively. The positive predictive value of a vaginal hrHPV+ LSIL result for a subsequent histopathologic VAIN 2/3 diagnosis was 14.6%. No cases of VAIN 2/3 were diagnosed in the 11 patients with vaginal hrHPV− LSIL results. Correlations of vaginal cytologic, histopathologic, and human papillomavirus findings were quite similar to correlation findings previously reported in older women with cervical LSIL test results.
Dye–Sensitized Solar Cells: An Overview
Authors: Andrade Luísa , Ribeiro Helena Aguilar , Mendes Adélio 
Published: December 2011

AbstractToday, a particular interest in the development of alternative energy sources arises, especially motivated by the need of decreasing the dependency on fossil‐fuel resources, and also for the prospect of reducing CO2emissions. An attractive strategy to overcome the present energy problem is using renewable energy sources, such as the solar radiation, for producing clean energy. This article describes the main features of dye‐sensitized solar cells (DSCs), explaining their structure and working principles, and highlighting the characteristics of the main materials for high‐performance DSCs. After this brief discussion, the fundamentals behind electrochemical impedance spectroscopy (EIS) are described in order to allow the interpretation of the charge‐transfer kinetics of the different phenomena occurring in a DSC under operation. A phenomenological model addressing the major charge‐transfer mechanisms and energy losses is presented for a better understanding of the factors that limit the performance of DSCs. While a steady‐state approach allows the construction of the current‐voltage characteristics of the cell, the transient approach model is an invaluable tool to relate the phenomenological behavior with certain dynamic techniques, such as EIS.
Synthesis of a new compatibilisant agent PVC‐g‐MA and its use in the PVC/alfa composites
Authors: Hammiche Dalila , Boukerrou Amar , Djidjelli Hocine , Beztout Meriama , Krim Salem 
Published: December 2011

AbstractThe main objective of this research was to synthesize a new compatibilisant agent (PVC‐g‐MA), which was grafted from the maleic anhydride on the PVC chains. The presence of maleic anhydride grafting on PVC was made evident by infrared analysis. PVC‐g‐MA was used like compatibilisant to solve the problem of the incompatibility between the hydrophobic polymeric matrix (PVC) and hydrophilic fiber (alfa). Composites samples were prepared with different alfa fiber loading (10, 20, and 30 wt %) and incorporating PVC‐g‐MA (1, 3, and 5 wt %) or PP‐g‐MA (3 wt %). The tensile properties, the thermal stability and the morphology of the composites were investigated. The result indicated that the PVC‐g‐MA increased the interfacial adhesion between the fibers and the polymer matrix and this effect was better than that obtained for the maleated‐polypropylene‐coupled composites. Microstructure analysis of the fractured surfaces of MAPP modified composites confirmed improved interfacial bonding. The addition of alfa and PVC‐g‐MA increased the thermal stability of the composites. The temperature of degradation of the polymer matrix increased about 16°C in comparison to the noncoupled composite, indicating that PVC‐g‐MA improved the thermal stability of the polymer. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Distribution and targets of the relaxin‐3 innervation of the septal area in the rat
Authors: Olucha‐Bordonau Francisco E. , Otero‐García Marcos , Sánchez‐Pérez Ana M. , Núñez Ángel , Ma Sherie , Gundlach Andrew L. 
Published: December 2011

AbstractNeural tracing studies have revealed that the rat medial and lateral septum are targeted by ascending projections from the nucleus incertus, a population of tegmental GABA neurons. These neurons express the relaxin‐family peptide, relaxin‐3, and pharmacological modulation of relaxin‐3 receptors in medial septum alters hippocampal theta rhythm and spatial memory. In an effort to better understand the basis of these interactions, we have characterized the distribution of relaxin‐3 fibers/terminals in relation to different septal neuron populations identified using established protein markers. Dense relaxin‐3 fiber plexuses were observed in regions of medial septum containing hippocampal‐projecting choline acetyltransferase (ChAT)‐, neuronal nitric oxide synthase (nNOS)‐, and parvalbumin (PV)‐positive neurons. In lateral septum (LS), relaxin‐3 fibers were concentrated in the ventrolateral nucleus of rostral LS and the ventral nucleus of caudal LS, with sparse labeling in the dorsolateral and medial nuclei of rostral LS, dorsal nucleus of caudal LS, and ventral portion nuclei. Relaxin‐3 fibers were also observed in the septofimbrial and triangular septal nuclei. In the medial septum, we observed relaxin‐3‐immunoreactive contacts with ChAT‐, PV‐, and glutamate decarboxylase‐67‐positive neurons that projected to hippocampus, and contacts between relaxin‐3 terminals and calbindin‐ and calretinin‐positive neurons. Relaxin‐3 colocalized with synaptophysin in nerve terminals in all septal areas, and ultrastructural analysis revealed these terminals were symmetrical and contacted spines, somata, dendritic shafts, and occasionally other axonal terminals. These data predict that this GABA/peptidergic projection modulates septohippocampal activity and hippocampal theta rhythm related to exploratory navigation, defensive and ingestive behaviors, and responses to neurogenic stressors. J. Comp. Neurol. 520:1903–1939, 2012. © 2011 Wiley Periodicals, Inc.
Direct Synthesis of ZnO Nanowires on Nanopatterned Surface by Magnetron Sputtering
Authors: El Mel Abdel‐Aziz , Buffière Marie , Massuyeau Florian , Gautron Eric , Xu Wei , Choi Chang‐Hwan , Wéry Jany , Faulques Eric , Barreau Nicolas , Tessier Pierre‐Yves 
Published: December 2011

AbstractZnO nanowire arrays parallel to the substrate are directly deposited by magnetron sputtering on the top of nanometric silicon line patterns prepared as a template. This method of synthesis is very simple and avoids the complicated steps of ZnO lithography. The nanoline template patterns are created by laser interference lithography combined with deep reactive ion etching. The assembly and the alignment of the nanowires after the deposition process are studied by scanning electron microscopy (SEM). The dimensions of the nanowires are regulated by those of the nanoline template patterns. The nanowires of 150 nm in width, 90 nm in height, 20 mm in length are fabricated especially for the study of their microstructure and photoluminescence effects. The microstructure is explored by X‐ray diffraction (XRD) and high‐resolution (HR) transmission electron microscopy (TEM). The nanowires show well‐crystallized ZnO nanograins in the hexagonal würtzite structure with a (002) preferential orientation on the (100) silicon surface. The nanowires exhibit a typical photoluminescence spectrum of ZnO.
Deletion of aquaporin‐4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier
Authors: Eilert‐Olsen Martine , Haj‐Yasein Nadia Nabil , Vindedal Gry Fluge , Enger Rune , Gundersen Georg Andreas , Hoddevik Eystein Hellstrøm , Petersen Pétur Henry , Haug Finn‐Mogens S. , Skare Øivind , Adams Marvin E. , Froehner Stanley C. , Burkhardt John Michael , Thoren Anna E. , Nagelhus Erlend A. 
Published: December 2011

AbstractExpression of the water channel aquaporin‐4 (AQP4) at the blood–brain interface is dependent upon the dystrophin associated protein complex. Here we investigated whether deletion of the Aqp4 gene affects the molecular composition of this protein scaffold and the integrity of the blood–brain barrier. High‐resolution immunogold cytochemistry revealed that perivascular expression of α‐syntrophin was reduced by 60% in Aqp4−/− mice. Additionally, perivascular AQP4 expression was reduced by 88% in α‐syn−/− mice, in accordance with earlier reports. Immunofluorescence showed that Aqp4 deletion also caused a modest reduction in perivascular dystrophin, whereas β‐dystroglycan labeling was unaltered. Perivascular microglia were devoid of AQP4 immunoreactivity. Deletion of Aqp4 did not alter the ultrastructure of capillary endothelial cells, the expression of tight junction proteins (claudin‐5, occludin, and zonula occludens 1), or the vascular permeability to horseradish peroxidase and Evans blue albumin dye. We conclude that Aqp4 deletion reduces the expression of perivascular glial scaffolding proteins without affecting the endothelial barrier. Our data also indicate that AQP4 and α‐syntrophin are mutually dependent upon each other for proper perivascular expression. © Wiley Periodicals, Inc.
The use of CO2 for reversible pH shifting, and the removal of succinic acid in a polymer‐based two‐phase partitioning bioreactor
Authors: Hepburn Adam J. , Daugulis Andrew J. 
Published: December 2011

AbstractBACKGROUND: Succinic acid (SA) is an intermediate in the production of commodity chemicals, but SA bioproduction has not yet been commercialized due to end product inhibition and high product separation costs. Two‐phase partitioning bioreactors (TPPBs) can increase volumetric productivity through in situ product removal, although SA uptake by polymers requires a pH below the pKA2 of SA (4.2). It was proposed to reversibly reduce the pH with CO2 sparging for absorption of SA, followed by nitrogen stripping to allow continued bioproduction after returning to metabolic pH levels.RESULTS: At 1 atm CO2 sparging lowered the pH of RO water to 3.8 but only to 4.75 in medium, requiring acid/base pH adjustment in subsequent experiments. Actinobacillus succinogenes was temporarily exposed to pH 4.2 for between 5 min and 4 h to observe the effect on subsequent growth; cells could grow after up to 4 h of low pH exposure, sufficient time for SA uptake. Because atmospheric CO2 could not adequately lower the pH of medium, a TPPB was operated with the pH being shifted using strong acid/base; SA was recovered in situ, however, the accumulation of salts hindered further cell growth.CONCLUSION: Several key elements of this novel processing strategy were successfully demonstrated, and work is continuing with high pressure CO2 to achieve the desired pH adjustment levels. Copyright © 2011 Society of Chemical Industry
Questionnaire for impulsive‐compulsive disorders in Parkinson's Disease–Rating Scale
Authors: Weintraub Daniel , Mamikonyan Eugenia , Papay Kimberly , Shea Judith A. , Xie Sharon X. , Siderowf Andrew 
Published: December 2011

AbstractImpulse control disorders and related disorders (hobbyism‐punding and dopamine dysregulation syndrome) occur in 15% to 20% of Parkinson's disease (PD) patients. We assessed the validity and reliability of the Questionnaire for Impulsive‐Compulsive Disorders in Parkinson's Disease–Rating Scale (QUIP‐RS), a rating scale designed to measure severity of symptoms and support a diagnosis of impulse control disorders and related disorders in PD. A convenience sample of PD patients at a movement disorders clinic self‐completed the QUIP‐RS and were administered a semistructured diagnostic interview by a blinded trained rater to assess discriminant validity for impulse control disorders (n = 104) and related disorders (n = 77). Subsets of patients were assessed to determine interrater reliability (n = 104), retest reliability (n = 63), and responsiveness to change (n = 29). Adequate cutoff points (both sensitivity and specificity values >80% plus acceptable likelihood ratios) were established for each impulse control disorder and hobbyism‐punding. Interrater and retest reliability (intraclass correlation coefficient r) were >0.60 for all disorders. Participants in an impulse control disorder treatment study who experienced full (t = 3.65, P = .004) or partial (t = 2.98, P = .01) response demonstrated significant improvement on the rating scale over time, while nonresponders did not (t = 0.12, P = .91). The QUIP‐RS appears to be valid and reliable as a rating scale for impulse control disorders and related disorders in PD. Preliminary results suggest that it can be used to support a diagnosis of these disorders, as well as to monitor changes in symptom severity over time. © 2011 Movement Disorder Society
Self model theory: learning from the future
Authors: Dowrick Peter W. 
Published: December 2011

AbstractThis paper synthesizes findings and theoretical propositions across behavioral, cognitive, and neuropsychological theories, with significant new conceptualizations bearing upon processes of learning and performance. There is a need to explain ultrarapid learning within the framework of cognitive science. In video self modeling and in challenging circumstances, the speed of behavior change appears to be derived from feedforward, in which component behaviors (in the repertoire) are reconfigured to produce a new skill or level of performance. It is argued that ‘self modeling’ is fundamental to learning, and peer/other modeling serves as an alternative. Learning in this way produces a cognitive self‐simulation which can be accessed to trigger a behavioral response in a future context. Related neurological processes are indicated by ‘mental time travel’ (MTT) and specific brain activity during the imagination (simulation) of future personal events. There is evidence that some brain mechanisms (mirror neurons), involved in immediate imitation, are differentially responsive to images of self versus other. MTT (to future events) in cognitive neuroscience has so far been discussed only in terms of prediction and planning not behavior change. These issues are brought together by self model theory. Conclusions drawn in this paper include discussions of the value in ‘learning from the future’ as a ubiquitous human ability. Overall, the propositions of this theory should stimulate diverse future research, linking neurological and behavioral contributions to cognitive science. WIREs Cogn Sci 2012, 3:215–230. doi: 10.1002/wcs.1156This article is categorized under:

Psychology > Learning
Propionic acidemia: neonatal versus selective metabolic screening
Authors: Grünert S. C. , Müllerleile S. , de Silva L. , Barth M. , Walter M. , Walter K. , Meissner T. , Lindner M. , Ensenauer R. , Santer R. , Bodamer O. A. , Baumgartner M. R. , Brunner‐Krainz M. , Karall D. , Haase C. , Knerr I. , Marquardt T. , Hennermann J. B. , Steinfeld R. , Beblo S. , Koch H. G. , Konstantopoulou V. , Scholl‐Bürgi S. , van Teeffelen‐Heithoff A. , Suormala T. , Sperl W. , Kraus J. P. , Superti‐Furga A. , Schwab K. O. , Sass J. O. 
Published: December 2011

AbstractBackgroundWhereas propionic acidemia (PA) is a target disease of newborn screening (NBS) in many countries, it is not in others. Data on the benefit of NBS for PA are sparse.Study designTwenty PA patients diagnosed through NBS were compared to 35 patients diagnosed by selective metabolic screening (SMS) prompted by clinical findings, family history, or routine laboratory test results. Clinical and biochemical data of patients from 16 metabolic centers in Germany, Austria, and Switzerland were evaluated retrospectively. Additionally, assessment of the intelligent quotient (IQ) was performed. In a second step, the number of PA patients who have died within the past 20 years was estimated based on information provided by the participating metabolic centers.ResultsPatients diagnosed through NBS had neither a milder clinical course regarding the number of metabolic crises nor a better neurological outcome. Among NBS patients, 63% were already symptomatic at the time of diagnosis, and <10% of all patients remained asymptomatic. Among all PA patients, 76% were found to be at least mildly mentally retarded, with an IQ <69. IQ was negatively correlated with the number of metabolic decompensations, but not simply with the patients’ age. Physical development was also impaired in the majority of patients. Mortality rates tended to be lower in NBS patients compared with patients diagnosed by SMS.ConclusionEarly diagnosis of PA through NBS seems to be associated with a lower mortality rate. However, no significant benefit could be shown for surviving patients with regard to their clinical course, including the number of metabolic crises, physical and neurocognitive development, and long‐term complications.
Mission-oriented middleware for sensor-driven scientific systems
Authors: Dearle Alan , Dobson Simon 
Published: December 2011

AbstractCoordinating the networks needed for modern scientific data collection and control presents a significant challenge: they are typically power- and resource-constrained, operating in noisy and hostile environments, and need to adapt their behaviour to match their operation to their sensed environment while maintaining the scientific integrity of their observations. In this paper, we explore several aspects of managing and coordinating sensor-driven systems. We draw some conclusions about how to design, structure, and implement programming and middleware abstractions for long-lived and adaptive sensor networks.
The association of parental fatal and non-fatal suicidal behaviour with offspring suicidal behaviour and depression: a systematic review and meta-analysis
Authors: Geulayov G. , Gunnell D. , Holmen T. L. , Metcalfe C. 
Published: December 2011

BackgroundChildren whose parents die by, or attempt, suicide are believed to be at greater risk of suicidal behaviours and affective disorders. We systematically reviewed the literature on these associations and, using meta-analysis, estimated the strength of associations as well as investigated potential effect modifiers (parental and offspring gender, offspring age).MethodWe comprehensively searched the literature (Medline, PsycINFO, EMBASE, Web of Science), finding 28 articles that met our inclusion criteria, 14 of which contributed to the meta-analysis. Crude odds ratio and adjusted odds ratio (aOR) were pooled using fixed-effects models.ResultsControlling for relevant confounders, offspring whose parents died by suicide were more likely than offspring of two living parents to die by suicide [aOR 1.94, 95% confidence interval (CI) 1.54–2.45] but there were heterogeneous findings in the two studies investigating the impact on offspring suicide attempt (aOR 1.31, 95% CI 0.73–2.35). Children whose parents attempted suicide were at increased risk of attempted suicide (aOR 1.95, 95% CI 1.48–2.57). Limited evidence indicated that exposure to parental death by suicide is associated with subsequent risk of affective disorders. Maternal suicidal behaviour and younger age at exposure were associated with larger effect estimates but there was no evidence that the association differed in sons versus daughters.ConclusionsParental suicidal behaviour is associated with increased risk of offspring suicidal behaviour. Findings suggest that maternal suicidal behaviour is a more potent risk factor than paternal, and that children are more vulnerable than adolescents and adults. However, there is no evidence of a stronger association in either male or female offspring.
Levinas's faithfulness to Husserl, phenomenology, and God
Authors: FINEGAN THOMAS 
Published: December 2011

AbstractThe contemporary debate in phenomenology concerning the ‘theological turn’ raises the issue of the relationship between faith and reason. One of the foremost statements on the theological turn, that of Dominique Janicaud, is an affirmation of the faith–reason dichotomy in the context of phenomenology, specifically in relation to how thinkers like Emmanuel Levinas have abused the phenomenological project of its founder, Edmund Husserl. This article challenges the faith–reason dichotomy and shows that the role of faith in Levinas need not mark him out as a deviant from Husserlian phenomenology.
Making crime pay in late eighteenth-century Bristol: stolen goods, the informal economy and the negotiation of risk
Authors: NEALE MATT 
Published: December 2011

ABSTRACTThis article examines the many ways that stolen goods were sold and circulated in late eighteenth-century Bristol. It argues that while historians have been correct to identify the contemporary importance of second-hand markets and the ‘informal economy’ to the sale of stolen property, some of the ways that stolen goods markets have been described and conceptualised are not fully supported by the evidence from Bristol. This raises questions about the extent to which models of crime based on London can be applied to cities in provincial England. The article also examines the influence that timing, appearance and location had on the way that stolen goods were sold.
Blue and green are frequently seen: responses of seeds to short- and mid-wavelength light
Authors: Goggin Danica E. , Steadman Kathryn J. 
Published: December 2011

AbstractSeeds have long been a model system for studying the intricacies of phytochrome-mediated light perception and signalling. However, very little is known about how they perceive blue and green light. Cryptochromes and phototropins, the major blue-light receptors in plants, are increasingly well-studied in vegetative tissues, but their role in light perception in seeds largely remains a mystery. Green light elicits a number of responses in plants that cannot be explained by the action of any of the known photoreceptors, and some seeds are apparently also capable of perceiving green light. Here, the responses of seeds to blue and green light are collated from a thorough examination of the literature and considered from the perspective of the potential photoreceptor(s) mediating them. Knowledge of how seeds perceive wavelengths that are suboptimal for phytochrome activation could help to improve germination and seedling establishment for both crop and native species.