bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early feasibility study with an implantable near-infrared spectroscopy sensor for glucose, ketones, lactate and ethanol
Authors: De Ridder Francesca , Braspenning Rie , Ordonez Juan S. , Klarenbeek Gijs , Lauwers Patrick , Ledeganck Kristien J. , Delbeke Danaë , De Block Christophe 
Published: May 2024

Objective
To evaluate the safety and performance of an implantable near-infrared (NIR) spectroscopy sensor for multi-metabolite monitoring of glucose, ketones, lactate, and ethanol.

Research design and methods
This is an early feasibility study (GLOW, NCT04782934) including 7 participants (4 with type 1 diabetes (T1D), 3 healthy volunteers) in whom the YANG NIR spectroscopy sensor (Indigo) was implanted for 28 days. Metabolic challenges were used to vary glucose levels (40–400 mg/dL, 2.2–22.2 mmol/L) and/or induce increases in ketones (ketone drink, up to 3.5 mM), lactate (exercise bike, up to 13 mM) and ethanol (4–8 alcoholic beverages, 40-80g). NIR spectra for glucose, ketones, lactate, and ethanol levels analyzed with partial least squares regression were compared with blood values for glucose (Biosen EKF), ketones and lactate (GlucoMen LX Plus), and breath ethanol levels (ACE II Breathalyzer). The effect of potential confounders on glucose measurements (paracetamol, aspartame, acetylsalicylic acid, ibuprofen, sorbitol, caffeine, fructose, vitamin C) was investigated in T1D participants.

Results
The implanted YANG sensor was safe and well tolerated and did not cause any infectious or wound healing complications. Six out 7 sensors remained fully operational over the entire study period. Glucose measurements were sufficiently accurate (overall mean absolute (relative) difference MARD of 7.4%, MAD 8.8 mg/dl) without significant impact of confounders. MAD values were 0.12 mM for ketones, 0.16 mM for lactate, and 0.18 mM for ethanol.

Conclusions
The first implantable multi-biomarker sensor was shown to be well tolerated and produce accurate measurements of glucose, ketones, lactate, and ethanol.

Trial registration
Clinical trial identifier: NCT04782934.
Changes in mental distress among employees during the three years of the COVID-19 pandemic in Germany
Authors: Casjens Swaantje , Taeger Dirk , Brüning Thomas , Behrens Thomas 
Published: May 2024

Objectives
The COVID-19 pandemic changed the future of work sustainably and led to a general increase in mental stress. A study conducted during the second and third pandemic wave with a retrospective survey of the first wave among 1,545 non-healthcare workers confirmed an increase in anxiety and depression symptoms and showed a correlation with the occupational SARS-CoV-2 infection risk. This online follow-up survey aims to examine changes in mental distress as the pandemic progressed in Germany and to identify factors influencing potential changes.

Methods
Longitudinal data from 260 subjects were available for this analysis. Mental distress related to anxiety and depression symptoms, assessed by the Patient Health Questionnaire-4 (PHQ-4), and occupational risk factors were solicited at the end of 2022 and retrospectively at the fifth wave. Categorized PHQ-4 scores were modelled with mixed ordinal regression models and presented with odds ratios (OR) and 95% confidence intervals (95% CI).

Results
A previous diagnosis of a depressive or anxiety disorder was a strong risk factor for severe symptoms (OR 3.49, 95% CI 1.71–7.11). The impact of occupational SARS-CoV-2 infection risk on mental distress was increased, albeit failing to reach the formal level of statistical significance (high risk OR 1.83, 95% CI 0.59–5.63; probable risk OR 1.72, 95% CI 0.93–3.15). Mental distress was more pronounced in those with a previous diagnosis of anxiety and depression. Confirmed occupational risk factors were protective measures against occupational SARS-CoV-2 infection perceived as inadequate, chronic work-related stress, overcommitment, reduced interactions with fellow-workers, and work-privacy conflicts.

Conclusions
The pandemic had a negative impact on anxiety and depression symptoms among the studied non-healthcare workers, particularly early in the pandemic, although this effect does not appear to be permanent. There are modifiable risk factors that can protect workers’ mental health, including strengthening social interactions among employees and reducing work-privacy conflicts.
Prevalence of oral rehydration solution use and its determinants in the treatment of diarrhea among under-five children in sub-Saharan Africa
Authors: Adedokun Sulaimon T. , Yaya Sanni 
Published: May 2024

Background
Diarrhea is the second leading cause of under-five deaths claiming half a million children every year. Most of these deaths occurred in sub-Saharan Africa and South Asia. Oral rehydration solution (ORS) has been described as the most effective treatment of diarrhea. However, only 36% of children with diarrhea received ORS in sub-Saharan Africa. This study examined the factors associated with ORS use for children with diarrhea in the sub-region.

Methods
Demographic and Health Surveys (DHS) data sets of 31 countries in sub-Saharan Africa were used in this study. The data involved 30,102 under-five children with diarrhea. The multivariable analysis involved binary logistic regression.

Results
Prevalence of ORS use was 38% in sub-Saharan Africa with countries such as Namibia (71.8%), Zambia (66.4%) and Malawi (63.8%) having the highest rates. Use of ORS was most common among children whose mothers had secondary or higher education (45%), were exposed to media (41%) and attended antenatal care (41%). ORS use was significantly associated with secondary or higher education (OR = 1.63; 95%CI: [1.47–1.81]; p<0.001), exposure to media (OR = 1.17; 95%CI: [1.07–1.27]; p<0.001), antenatal care attendance (OR = 2.33; 95%CI: [1.08–1.27]; p<0.001), child’s age (OR = 1.46; 95%CI: [1.35–1.59]; p<0.001), child’s size at birth (OR = 1.08; 95%CI: [1.00–1.17]; p<0.05), household size (OR = 1.28; 95%CI:[1.06–1.54]; p<0.05) and source of drinking water (OR = 1.18; 95%CI: [1.09–1.29]; p<0.001).

Conclusion
This study revealed a 38% prevalence of ORS use during diarrhea episodes in sub-Saharan Africa. This is low as it is less than the 44% recorded for developing countries as a whole. While this study emphasises the need for a further study on effects of severity of diarrhea on ORS use and factors determining differences in ORS use among countries, it also calls for interventions that will increase use of ORS is sub-Saharan Africa. Such interventions should include increase in literacy rate among girls and women, increase in the proportion of women with access to media, involvement of health workers in programmes that would promote antenatal care utilization among women at community level and provision of social amenities like pipe-borne water.
Circulating extracellular vesicle characteristics differ between men and women following 12 weeks of concurrent exercise training
Authors: Kargl Christopher K. , Sterczala Adam J. , Santucci Daniella , Conkright William R. , Krajewski Kellen T. , Martin Brian J. , Greeves Julie P. , O'Leary Thomas J. , Wardle Sophie L. , Sahu Amrita , Ambrosio Fabrisia , Nindl Bradley C. 
Published: May 2024

AbstractConcurrent resistance and endurance exercise training (CET) has well‐studied benefits; however, inherent hormonal and genetic differences alter adaptive responses to exercise between sexes. Extracellular vesicles (EVs) are factors that contribute to adaptive signaling. Our purpose was to test if EV characteristics differ between men and women following CET. 18 young healthy participants underwent 12‐weeks of CET. Prior to and following CET, subjects performed an acute bout of heavy resistance exercise (AHRET) consisting of 6 × 10 back squats at 75% 1RM. At rest and following AHRET, EVs were isolated from plasma and characteristics and miRNA contents were analyzed. AHRET elevated EV abundance in trained men only (+51%) and AHRET‐induced changes were observed for muscle‐derived EVs and microvesicles. There were considerable sex‐specific effects of CET on EV miRNAs, highlighted by larger variation following the 12‐week program in men compared to women at rest. Pathway analysis based on differentially expressed EV miRNAs predicted that AHRET and 12 weeks of CET in men positively regulates hypertrophy and growth pathways more so than in women. This report highlights sex‐based differences in the EV response to resistance and concurrent exercise training and suggests that EVs may be important adaptive signaling factors altered by exercise training.
Reallabore in und für Bibliotheken – der Versuch einer Einordnung
Authors: Georgy Ursula 
Published: May 2024

Zusammenfassung
Das Thema Reallabore, auch vielfach bezeichnet als Living Labs, nimmt in den letzten Jahren an Fahrt auf. Auch Bibliotheken sind bereits auf den Trend aufgesprungen. Dieser Beitrag ordnet das Thema der Reallabore in das Innovationsmanagement ein und stellt dar, welche Möglichkeiten der Partizipation sich Bibliotheken durch Reallabore eröffnen.
Panel Technical Efficiency of Korean Companies in the Energy Sector based on Digital Capabilities
Authors: Choi Jong Woo , Park Chankook 
Published: May 2024

Abstract
Digitalization is a crucial driver of enhanced energy system efficiency, facilitating the energy transition and offering a gateway for technology companies to enter the sector. This study, employing stochastic frontier analysis as the chosen methodology, investigates the efficiency challenges faced by companies venturing into the energy industry with a digital technology focus. Our empirical analysis reveals a positive correlation between higher total assets and increased research and development expenditures, signifying the vital importance of talent acquisition and securing R&D funding. Additionally, it is noteworthy that smaller companies experienced a more pronounced negative impact of COVID-19 on their efficiency. These findings contribute to refining digitalization strategies in the energy industry, emphasizing the role of efficiency from a corporate perspective.
An optimal concentric circular antenna array design using atomic orbital search for communication systems
Authors: Durmus Ali , Yildirim Zafer , Kurban Rifat , Karakose Ercan 
Published: May 2024

Abstract
In this study, optimum radiation patterns of Concentric Circular Antenna Arrays (CCAAs) are obtained by using the Atomic Orbital Search (AOS) algorithm for communication spectrum. Communication systems stands as a nascent technological innovation poised to revolutionize the landscape of wireless communication systems. It distinguishes itself through its hallmark features, notably an exceptionally high data transmission rate, expanded network capacity, minimal latency, and a commendable quality of service. The most important issue in wireless communication is a precision antenna array design. The success of this design depends on suppressing the maximum sidelobe levels (MSLs) values of the antenna in the far-field radiation region as much as possible. The AOS, which is a rapid and flexible search algorithm, is a novel physics-based algorithm. The amplitudes and inter-element spacing of CCAAs are optimally determined by utilizing AOS to the reduction of the MSLs. In this study, CCAAs with three and four rings are considered. The number of elements of these CCAAs has been determined as 4–6–8, 8–10–12 and 6–12–18–24. The radiation patterns obtained with AOS are compared with the results available in the literature and it is seen that the results of the AOS method are better.
The role of digital technologies and Human-Computer Interaction for the future of education
Authors: Herczeg Michael 
Published: May 2024

Abstract
Over the last 50 years education has been transformed by digital technologies. Many efforts have been made to create and apply “digital” teaching and learning methods, tools and platforms. The last 25 years of computer-based education can be characterized by the availability of digital information sources and the implementation and operation of digital learning management platforms based on the Internet. The question about further meaningful and effective progress in the next decades is openly discussed. Many expect strong influences and changes from artificial intelligence systems that generate contextualized information from various sources. Some see interactive virtual worlds expanding and partially replacing the physical world. Many believe in the further development of learning management and communication platforms. Others do not expect much valuable change at all due to the slow pace of complex educational systems with recent studies even showing a decline in the quality of educational outcomes during the last five years as a result of even too much digitalization in education. This paper discusses these positions with an emphasis on the roles of humans and computers and their interfaces, i.e. Human-Computer Interaction, for future learning and teaching with rapidly changing information technologies in the next 25 and 50 years.
Palm oil amends serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation in favism-induced female rats
Authors: Koriem Khaled M. M. , Arbid Mahmoud S. S. 
Published: May 2024

Abstract

Background
Favism is a metabolic disease and this study evaluates the effectiveness of palm oil and its triacylglycerol constituent in favism-induced female rats to restore serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation.

Methods
Animals were 36 female albino rats. They classified to two equal (normal and favism) groups. The normal group was divided into three equal subgroups: the control, palm oil, and triacylglycerol subgroups. The normal rats were given 1 mL of saline, 1 mL of palm oil, and 1 mL of triacylglycerol orally, respectively. The Favism group was classified also into three equal subgroups: the favism group, the favism + palm oil, the Favism + triacylglycerol. The favism rats were given 1 mL of saline, 1 mL of palm oil, and 1 mL of triacylglycerol orally. For four weeks, all treatments were administered orally via oral gavage once daily.

Results
The hemoglobin, hematocrite, the blood cells, glucose and glucose-6-phosphate dehydrogenase, and liver function were decreased in favism. Female hormones such as serum luteinizing hormone, follicle stimulating hormone, Estrone, Estriol, 17α-Estradiol, 17β-Estradiol, and Estradiol-17-β-stearate were decreased in favism. Ovarian antioxidants were decreased while ovarian inflammatory markers were increased in favism. Favism induced ovarian DNA apoptosis. Furthermore, oral administration with palm oil or its triacylglycerol constituent in favism-induced female rats restored all these parameters to be approached the control levels.

Conclusions
Palm oil restored serum female hormones, ovarian antioxidants, inflammatory markers, and DNA fragmentation in favism-induced female rats and this effect related to oil triacylglycerol constituent.
Hamlet and Pure Object Revenge – The Matter of Life and Death
Authors: Watt Gary 
Published: May 2024

Abstract
Why do we strike intrinsically inoffensive objects when they intrude upon our lives? Why, for example, do we kick the car when it breaks down, or slap the chair that pinches our finger against the table, or strike the open door that collides with our head? In this essay, I ask whether this phenomenon, which I call the performance of “pure object revenge”, might arise from an impulse to execute vindicatory, and in that sense vengeful, justice upon the offending object. My new explanation for the phenomenon is that we strike the offending object because it has no life but has briefly acted as if it were alive. It therefore reminds us in the brief moment of its offence that our bodies are also inanimate dust and will return to dust and in the meantime are only briefly animated. In short, my argument is that we strike the object because it is a memento mori. To test and support this, I offer a reading of the “closet scene” at the centre of Shakespeare’s Hamlet to illustrate the performative impulse to banish inanimate objects at the threshold of the living and the dead.
Higher Education in Northern Cyprus: The Path from Isolation to Oversaturation
Authors: Hoch Tomáš , Heinz Viktor 
Published: May 2024

Abstract
This study explores the problems related to university teaching and academic research within de facto states in the context of their non-recognition via an analysis of the current situation in the higher education sector of Northern Cyprus. It reveals that although Northern Cyprus is a world leader in terms of the number of universities per capita, as well as the proportion of international students and the proportion of higher education students in its population, its higher education system nevertheless faces numerous problems. Among the most serious of these are the inconsistent and often very low quality of Northern Cyprus’s universities, the politicisation of and lack of confidence in the accreditation authorities responsible for the quality and sustainability of the higher education system, and the unregulated activities of “agents” who recruit new students.
Computational analysis of the scramjet mode of the RBCC inlet using micro vortex generators
Authors: Raj Ritul , Joshi Ganapati N. , Chandel Sunil , Mishra Ranjan Kumar 
Published: May 2024

Abstract
A computational study of a three ramped dual duct Rocket Based Combined Cycle (RBCC) engine inlet at scramjet mode using different types of MVG (micro vortex generator) arrays were conducted. The definite geometry of engine inlet was operated at hypersonic speeds of Mach 5 and 7 to study the effect of the arrays of delta ramp (DR), rectangular vane (RRV) and ramp vane (RV) on the pressure recovery, exit Mach number, the mass flow rate and Shock wave Boundary Layer interaction (SWBLI). The study was performed considering same heights for all the configurations of MVG array and were positioned at the point of shock impingement on the ramp which caused the separation bubble. The computational analysis was done using k-omega model in Fluent Workbench of Ansys.
Blood plasma proteins and the content of metabolites of carbohydrate and lipid metabolism in the hepatopancreas of fish during the action 19-nortestosterone
Authors: Zakharenko Mykola , Romanova Ella 
Published: May 2024

The aim: study the effect of the synthetic anabolic steroid 19-nortestosterone on the fractional composition of blood plasma proteins, as well as the total protein and albumin content, indicators of the metabolism of carbohydrates, lipids, macro- and microelements in the fish hepatopancreas.
Materials and methods. The experiments were conducted on two-year-old carp (Cyprinus carpio L.), which were kept for 24 hours in aquariums with a volume of 40 dm3 with different concentrations of 19-nortestosterone in water at optimal temperature, oxygen content, and pH. Spectrophotometric methods and an automatic biochemical analyzer were used to determine metabolic indicators in fish, and disk electrophoresis in PAGE was used to determine the fractional composition of proteins.
Results. It was established that the steroid hormone 19-nortestosterone, the concentration of which in the water of the fish of the experimental groups was 50 and 200 μg/dm3, respectively, increased the level of total protein and albumin, the concentration of glucose, triglycerides, creatinine, inorganic phosphorus and iron in the hepatopancreas and did not affect the calcium content . In the blood plasma of carp, kept in water with a concentration of 19-nortestosterone of 50 μg/dm3, the content of proteins with a molecular weight of 240-231 increases; 215-179; 169-146 and 105-95 kDa, decreases - 35-33 kDa, fractions of proteins with a molecular weight of 228-220 appear; 116-105 and 48-44 kDa. An increase in the concentration of 19-nortestosterone in water to 200 μg/dm3 increased the content of proteins with a molecular weight of 240-231 and 215-179 kDa in the blood plasma of fish, and decreased it by 35-33 kDa, causing the redistribution of individual protein fractions due to the appearance of proteins with a molecular weight of 240 -228; 116-105 and 48-44 kDa in the absence of proteins 42-41; 38-36 and 24-20 kDa.
Conclusions. Based on the obtained results, it was concluded that the anabolic synthetic steroid 19-nortestosterone stimulates the biosynthesis of proteins, the metabolism of carbohydrates and lipids, and its effect on the content of minerals in the hepatopancreas and the fractional composition of blood plasma proteins in carp fish was proven
ROSPECTS FOR THE USE OF WILD BERRY PROCESSING PRODUCTS AS FUNCTIONAL FOOD INGREDIENTS
Authors: Demidova E. , Samilyk M. 
Published: May 2024

The aim of this study is to substantiate the feasibility of processing wild berries (Viburnum opulus, Sorbus, Hippophae, Sambucus nigra) into functional food ingredients. The paper analyses the structure of powders from wild berries Viburnum opulus, Sorbus, Hippophae, Sambucus nigra, and investigates the content of micro- and macroelements in the powders; physicochemical parameters of wild berry powders (dry matter, mass fraction of moisture, dispersibility, mass fraction of reducing sugars, solubility, acidity) and dietary fibre content in Viburnum opulus, Sorbus, Hippophae, Sambucus nigra powders. The prototypes were made from high-quality fruit and berry raw materials not damaged by diseases and pests. To make the powders, the berries were dehydrated by osmotic dehydration, then dried in infrared dryers for 2 hours at 50°C to a mass fraction of moisture of 6–8 %. The dried berries were ground in a laboratory mill LZM-1. The structure of the berry powders was studied by electron microscopy. It was found that the powders have a crystalline porous structure and, accordingly, hydrophilic properties. This makes it possible to use them in food production as structure stabilisers, emulsifiers and moisture retainers. The content of some minerals in the samples was studied using a microscope-based SEM and EDS detector. It was found that the powders contain macronutrients (K, Ca, P, Cl, S, N), essential trace elements (Mg) and the conditionally vital trace element Si, which was found in powders from viburnum and sea buckthorn. The obtained powders from wild berries Hippophae rhamnoides L., Viburnum opulus, Sambucus nigra and Sorbus aucuparia contain a significant amount of vitamin C. According to all physicochemical parameters, the samples of plant powders from viburnum, elderberry, sea buckthorn, and mountain ash berries meet the requirements of DSTU 8498:2015. These results indicate the feasibility of processing Viburnum opulus, Sorbus, Hippophae, Sambucus nigra into functional food ingredients.