bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mooring Systems: A State-of-the-Art Review
Authors: Skop R. A. 
Published: November 2009

Abstract
A mooring system is any system of cables and anchors used to restrain the motion of a fixed or floating structure by transmitting the forces on the structure to the seafloor. Examples of mooring systems range from the simple single-anchor, single-line system used to restrain meteorological buoys to the complex systems used to restrain tension leg platforms and guyed towers for deepwater oil operations. In this paper, a state-of-the-art review regarding the behavior of cables as mooring system components, the types and selection of cables, and the various classes of anchors and their applications is presented.
Prediction of the Current Structure Under Drifting Pack
Ice
Authors: Myrhaug D. 
Published: November 2009

Abstract
A simple analytical theory which describes the motion in a turbulent planetary boundary layer near a rough sea bed by using a two-layer eddy viscosity model is presented. An inverted boundary layer similar to that at the sea bed is applicable under the pack ice. The vertical structure of the current in the boundary layer is presented, and comparisons are made with data from McPhee and Smith [1] obtained from measurements of the turbulent boundary layer under drifting Arctic pack ice. The present model predictions for the drag coefficient at the ice surface and the direction of the surface shear stress are also compared with corresponding formulas given in Davenport [2], which are obtained as fits to observations in atmospheric boundary layers.
Recovery of antimicrobial-resistantEscherichia coliafter storage of bovine feces in Cary–Blair medium
Authors: Alexander T. W. , Booker C. W. , Gow S. P. , Read R. R. , McAllister T. A. 
Published: November 2009

The effect of storing bovine feces in Cary–Blair medium on the recovery of antimicrobial-resistant Escherichia coli was investigated. Feces from cattle at a research feedlot (n = 50) and at a commercial feedlot (n = 46) were processed immediately or after storage in Cary–Blair medium for 8 days at 5 °C. Total, ampicillin-resistant, and tetracycline-resistant E. coli were isolated. The number of total E. coli decreased slightly after storage (0.19 log units; p < 0.001), but storage of feces in Cary–Blair medium did not affect recovery of ampicillin- or tetracycline-resistant E. coli.
The role of rpoS on the survival of a p-nitrophenol degrading Pseudomonas putida strain in planktonic and biofilm phases
Authors: Maki M. L. , Lawrence J. R. , Swerhone G. D.W. , Leung K. T. 
Published: November 2009

The survival of and interactions between a Pseudomonas putida strain labelled with a red fluorescent protein gene (WT-rfp) and its green fluorescent protein gene-labelled rpoS– mutant (KO-gfp) were examined. The generation times of the planktonic WT-rfp and KO-gfp in trypticase soy broth were not significantly different (i.e., p > 0.05) from each other at 30 °C. However, the biovolume of the KO-gfp biofilm was about 7 times larger than its WT-rfp counterpart after 48 h of growth. Furthermore, the presence of WT-rfp suppressed the biofilm development of KO-gfp significantly in co-culture biofilms. In planktonic conditions, the pre-carbon-starved WT-rfp achieved a 3-fold greater survival than the pre-carbon-starved KO-gfp in 0.85% saline after a 13-day incubation. In a 1:1 ratio co-culture, the pre-carbon-starved WT-rfp outcompeted the pre-carbon-starved KO-gfp by 20-fold. However, the survival of WT-rfp and KO-gfp were not significantly different from each other in biofilm conditions. Additionally, 11.4% and 61.2% of the WT-rfp and KO-gfp biofilms, respectively, remained intact after washing in 0.2% SDS for 60 min. In conclusion, the rpoS had a significant impact on survival and competitiveness of planktonic P. putida, and on biofilm development, being implicated in competitive suppression of biofilm development in co-culture biofilms and decreased biofilm cohesiveness.
Cryptanalysis of the random number generator of the Windows operating system
Authors: Dorrendorf Leo , Gutterman Zvi , Pinkas Benny 
Published: November 2009

The PseudoRandom Number Generator (PRNG) used by the Windows operating system is the most commonly used PRNG. The pseudorandomness of the output of this generator is crucial for the security of almost any application running in Windows. Nevertheless, its exact algorithm was never published.

We examined the binary code of a distribution of Windows 2000. This investigation was done without any help from Microsoft. We reconstructed the algorithm used by the pseudorandom number generator (namely, the function CryptGenRandom). We analyzed the security of the algorithm and found a nontrivial attack: Given the internal state of the generator, the previous state can be computed in 2
23
steps. This attack on forward security demonstrates that the design of the generator is flawed, since it is well known how to prevent such attacks. After our analysis was published, Microsoft acknowledged that Windows XP is vulnerable to the same attack.

We also analyzed the way in which the generator is used by the operating system and found that it amplifies the effect of the attack: The generator is run in user mode rather than in kernel mode; therefore, it is easy to access its state even without administrator privileges. The initial values of part of the state of the generator are not set explicitly, but rather are defined by whatever values are present on the stack when the generator is called. Furthermore, each process runs a different copy of the generator, and the state of the generator is refreshed with system-generated entropy only after generating 128KB of output for the process running it. The result of combining this observation with our attack is that learning a single state may reveal 128KB of the past and future output of the generator.
The implication of these findings is that a buffer overflow attack or a similar attack can be used to learn a single state of the generator, which can then be used to predict all random values, such as SSL keys, used by a process in all its past and future operations. This attack is more severe and more efficient than known attacks in which an attacker can only learn SSL keys if it is controlling the attacked machine at the time the keys are used.
Higher-order term indexing using substitution trees
Authors: Pientka Brigitte 
Published: November 2009

We present a higher-order term indexing strategy based on substitution trees for simply typed lambda-terms. There are mainly two problems in adapting first-order indexing techniques. First, many operations used in building an efficient term index and retrieving a set of candidate terms from a large collection are undecidable in general for higher-order terms. Second, the scoping of variables and binders in the higher-order case presents challenges.
The approach taken in this article is to reduce the problem to indexing linear higher-order patterns, a decidable fragment of higher-order terms, and delay solving terms outside of this fragment. We present insertion of terms into the index based on computing the most specific linear generalization of two linear higher-order patterns, and retrieval based on matching two linear higher-order patterns. Our theoretical framework maintains that terms are in βη-normal form, thereby eliminating the need to renormalize and raise terms during insertion and retrieval. Finally, we prove correctness of our presented algorithms. This indexing structure is implemented as part of the Twelf system to speed up the execution of the tabled higher-logic programming interpreter.
Guest editorial on cultural issues in global e-commerce diffusion, adoption and use
Authors: Dwivedi Yogesh K. , Singh Nitish , Williams Michael D. 
Published: November 2009

It gives us great pleasure to welcome you to this special issue of DATA BASE for Advances in Information Systems, the focus of which is on "Cultural Issues in Global E-commerce Diffusion, Adoption and Use."
Electronic (e)-commerce is expanding at a rapid rate, with the online population approaching almost one and a half billion, and global online revenues being measured in trillions of dollars. This global expansion of e-commerce represents growth opportunities for businesses worldwide. However, one of the obstacles for companies attempting to extend their e-business internationally is to understand global consumers and overcome cultural barriers and language differences on the web (Singh and Pereira, 20051; Violino, 20012). Many companies are realizing that building an e-commerce website to suit an international audience is a more complex endeavor than they expected (Sheldon and Strader, 20023). As companies set up their global e-businesses, it is important for them to understand, what global trends are facilitating the rise of the web, what cultural factors influence consumer use of international websites, what motivates global consumers to make purchases at international websites, and what cultural barriers exist to diffusion and adoption of e-commerce.
This Special Issue of DATA BASE aims to advance the knowledge on the role of national culture in global e-commerce expansion. More specifically, it aims to address issues related to the impact of national culture on macro-level issues related to diffusion and adoption of ecommerce, and micro-level issues related to web site localization, international web site usage, and global online consumer behavior. The Special Issue has solicited theoretical, conceptual, and empirical studies that are inter-disciplinary in nature, as global e-commerce research is not just emerging as an important area of study in the information systems domain, but also in marketing, international business, linguistics and other disciplines.
Epigenetic Repression of microRNA-129-2 Leads to Overexpression of SOX4 Oncogene in Endometrial Cancer
Authors: Huang Yi-Wen , Liu Joseph C. , Deatherage Daniel E. , Luo Jingqin , Mutch David G. , Goodfellow Paul J. , Miller David S. , Huang Tim H-M. 
Published: November 2009

Abstract
Genetic amplification, mutation, and translocation are known to play a causal role in the upregulation of an oncogene in cancer cells. Here, we report an emerging role of microRNA, the epigenetic deregulation of which may also lead to this oncogenic activation. SOX4, an oncogene belonging to the SRY-related high mobility group box family, was found to be overexpressed (P &lt; 0.005) in endometrial tumors (n = 74) compared with uninvolved controls (n = 20). This gene is computationally predicted to be the target of a microRNA, miR-129-2. When compared with the matched endometria, the expression of miR-129-2 was lost in 27 of 31 primary endometrial tumors that also showed a concomitant gain of SOX4 expression (P &lt; 0.001). This inverse relationship is associated with hypermethylation of the miR-129-2 CpG island, which was observed in endometrial cancer cell lines (n = 6) and 68% of 117 endometrioid endometrial tumors analyzed. Reactivation of miR-129-2 in cancer cells by pharmacologic induction of histone acetylation and DNA demethylation resulted in decreased SOX4 expression. In addition, restoration of miR-129-2 by cell transfection led to decreased SOX4 expression and reduced proliferation of cancer cells. Further analysis found a significant correlation of hypermethylated miR-129-2 with microsatellite instability and MLH1 methylation status (P &lt; 0.001) and poor overall survival (P &lt; 0.039) in patients. Therefore, these results imply that the aberrant expression of SOX4 is, in part, caused by epigenetic repression of miR-129-2 in endometrial cancer. Unlike the notion that promoter hypomethylation may upregulate an oncogene, we present a new paradigm in which hypermethylation-mediated silencing of a microRNA derepresses its oncogenic target in cancer cells. [Cancer Res 2009;69(23):9038–46]
Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung Adenocarcinoma
Authors: Goto Yasuhiro , Shinjo Keiko , Kondo Yutaka , Shen Lanlan , Toyota Minoru , Suzuki Hiromu , Gao Wentao , An Byonggu , Fujii Makiko , Murakami Hideki , Osada Hirotaka , Taniguchi Tetsuo , Usami Noriyasu , Kondo Masashi , Hasegawa Yoshinori , Shimokata Kaoru , Matsuo Keitaro , Hida Toyoaki , Fujimoto Nobukazu , Kishimoto Takumi , Issa Jean-Pierre J. , Sekido Yoshitaka 
Published: November 2009

Abstract
Malignant pleural mesothelioma (MPM) is a fatal thoracic malignancy, the epigenetics of which are poorly defined. We performed high-throughput methylation analysis covering 6,157 CpG islands in 20 MPMs and 20 lung adenocarcinomas. Newly identified genes were further analyzed in 50 MPMs and 56 adenocarcinomas via quantitative methylation-specific PCR. Targets of histone H3 lysine 27 trimethylation (H3K27me3) and genetic alterations were also assessed in MPM cells by chromatin immunoprecipitation arrays and comparative genomic hybridization arrays. An average of 387 genes (6.3%) and 544 genes (8.8%) were hypermethylated in MPM and adenocarcinoma, respectively. Hierarchical cluster analysis showed that the two malignancies have characteristic DNA methylation patterns, likely a result of different pathologic processes. In MPM, a separate subset of genes was silenced by H3K27me3 and could be reactivated by treatment with a histone deacetylase inhibitor alone. Integrated analysis of these epigenetic and genetic alterations revealed that only 11% of heterozygously deleted genes were affected by DNA methylation and/or H3K27me3 in MPMs. Among the DNA hypermethylated genes, three (TMEM30B, KAZALD1, and MAPK13) were specifically methylated only in MPM and could serve as potential diagnostic markers. Interestingly, a subset of MPM cases (4 cases, 20%) had very low levels of DNA methylation and substantially longer survival, suggesting that the epigenetic alterations are one mechanism affecting progression of this disease. Our findings show a characteristic epigenetic profile of MPM and uncover multiple distinct epigenetic abnormalities that lead to the silencing of tumor suppressor genes in MPM and could serve as diagnostic or prognostic targets. [Cancer Res 2009;69(23):9073–82]
Toll-like Receptors 3 and 7 Agonists Enhance Tumor Cell Lysis by Human γδ T Cells
Authors: Shojaei Hamed , Oberg Hans-Heinrich , Juricke Matthias , Marischen Lothar , Kunz Monika , Mundhenke Christoph , Gieseler Frank , Kabelitz Dieter , Wesch Daniela 
Published: November 2009

AbstractToll-like receptor (TLR) agonists are considered adjuvants in clinical trials of cancer immunotherapy. Here, we investigated the modulation of γδ T cell–mediated tumor cell lysis by TLR ligands. γδ T-cell cytotoxicity and granzyme A/B production were enhanced after pretreatment of tumor cells with TLR3 [poly(I:C)] or TLR7 ligand (imiquimod). We examined TLR3- and TLR7-expressing pancreatic adenocarcinomas, squamous cell carcinomas of head and neck and lung carcinomas. Poly(I:C) treatment of pancreatic adenocarcinomas followed by coculture with γδ T cells resulted in an upregulation of CD54 on the tumor cells. The interaction of CD54 and the corresponding ligand CD11a/CD18 expressed on γδ T cells is responsible for triggering effector function in γδ T cells. Moreover, treatment with imiquimod downregulated MHC class I molecules on tumor cells possibly resulting in a reduced binding affinity for inhibitory receptor NKG2A expressed on γδ T cells. These results indicate that TLR3 or TLR7 ligand stimulation of tumor cells enhances the cytotoxic activity of expanded γδ T cells of cancer patients in vitro. [Cancer Res 2009;69(22):8710–7]
Mammary Tumor Development in Dogs Is Associated with BRCA1 and BRCA2
Authors: Rivera Patricio , Melin Malin , Biagi Tara , Fall Tove , Häggström Jens , Lindblad-Toh Kerstin , von Euler Henrik 
Published: November 2009

Abstract
Breast cancer is a major contributor to overall morbidity and mortality in women. Several genes predisposing to breast cancer have been identified, but the majority of risk factors remain unknown. Even less is known about the inherited risk factors underlying canine mammary tumors (CMT). Clear breed predispositions exist, with 36% of English springer spaniels (ESS) in Sweden being affected. Here, we evaluate 10 human breast cancer genes (BRCA1, BRCA2, CHEK2, ERBB2, FGFR2, LSP1, MAP3K1, RCAS1, TOX3, and TP53) for association with CMTs. Sixty-three single-nucleotide polymorphisms (SNPs; four to nine SNPs per gene) were genotyped by iPLEX in female ESS dogs, 212 CMT cases and 143 controls. Two genes, BRCA1 and BRCA2, were significantly associated with CMT (Bonferroni corrected P = 0.005 and P = 0.0001, respectively). Borderline association was seen for FGFR2. Benign and malignant cases were also analyzed separately. Those findings supported the association to BRCA1 and BRCA2 but with a stronger association to BRCA1 in malignant cases. Both BRCA1 and BRCA2 showed odds ratios of ∼4. In conclusion, this study indicates that BRCA1 and BRCA2 contribute to the risk of CMT in ESS, suggesting that dogs may serve as a good model for human breast cancer. [Cancer Res 2009;69(22):8770–4]
Ubiquitination and Downregulation of BRCA1 by Ubiquitin-Conjugating Enzyme E2T Overexpression in Human Breast Cancer Cells
Authors: Ueki Tomomi , Park Jae-Hyun , Nishidate Toshihiko , Kijima Kyoko , Hirata Koichi , Nakamura Yusuke , Katagiri Toyomasa 
Published: November 2009

AbstractBreast cancer is generated through a multistep genetic and epigenetic process including activations of oncogenes and inactivations of tumor suppressor genes. Here, we report a critical role of ubiquitin-conjugating enzyme E2T (UBE2T), an E2 ubiquitin-conjugating enzyme, in mammary carcinogenesis. Immunocytochemical staining and in vitro binding assay revealed that UBE2T interacted and colocalized with the BRCA1/BRCA1-associated RING domain protein (BARD1) complex. Knocking down of UBE2T expression with small interfering RNA drastically suppressed the growth of breast cancer cells. Interestingly, in vivo ubiquitination assay indicated BRCA1 to be polyubiquitinated by incubation with wild-type UBE2T protein, but not with C86A-UBE2T protein, an E2 activity–dead mutant, in which the 86th residue of cysteine was replaced with alanine. Furthermore, knocking down of UBE2T protein induced upregulation of BRCA1 protein in breast cancer cells, whereas its overexpression caused the decrease of the BRCA1 protein. Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex. [Cancer Res 2009;69(22):8752–60]
Cell Fusion as a Hidden Force in Tumor Progression
Authors: Lu Xin , Kang Yibin 
Published: November 2009

Abstract
Cell fusion plays an essential role in fertilization, formation of placenta, bone and muscle tissues, immune response, tissue repair, and regeneration. Increasing recognition of cell fusion in somatic cell dynamics has revitalized the century-old hypothesis that cell fusion may contribute to the initiation and progression of cancer. In this review, we discuss findings from experimental and clinical studies that suggest a potentially multifaceted involvement of cell fusion in different stages of tumor progression, including aneuploidy and tumor initiation, origin of cancer stem cells, multidrug resistance, and the acquisition and diversification of metastatic abilities. [Cancer Res 2009;69(22):8536–9]
Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells
Authors: Yamaguchi Hideki , Takeo Yukiko , Yoshida Shuhei , Kouchi Zen , Nakamura Yoshikazu , Fukami Kiyoko 
Published: November 2009

Abstract
Invadopodia are ventral membrane protrusions through which invasive cancer cells degrade the extracellular matrix. They are thought to function in the migration of cancer cells through tissue barriers, which is necessary for cancer invasion and metastasis. Although many protein components of invadopodia have been identified, the organization and the role of membrane lipids in invadopodia are not well understood. In this study, the role of lipid rafts, which are cholesterol-enriched membrane microdomains, in the assembly and function of invadopodia in human breast cancer cells was investigated. Lipid rafts are enriched, internalized, and dynamically trafficked at invadopodia sites. Perturbation of lipid raft formation due to depleting or sequestering membrane cholesterol blocked the invadopodia-mediated degradation of the gelatin matrix. Caveolin-1 (Cav-1), a resident protein of lipid rafts and caveolae, accumulates at invadopodia and colocalizes with the internalized lipid raft membranes. Membrane type 1 matrix metalloproteinase (MT1-MMP), a matrix proteinase associated with invadopodia, is localized at lipid raft-enriched membrane fractions and cotrafficked and colocalized with Cav-1 at invadopodia. The small interfering RNA–mediated silencing of Cav-1 inhibited the invadopodia-mediated and MT1-MMP–dependent degradation of the gelatin matrix. Furthermore, Cav-1 and MT1-MMP are coexpressed in invasive human breast cancer cell lines that have an ability to form invadopodia. These results indicate that invadopodia are the sites where enrichment and trafficking of lipid rafts occur and that Cav-1 is an essential regulator of MT1-MMP function and invadopodia-mediated breast cancer cell invasion. [Cancer Res 2009;69(22):8594–602]
Functional Significance of Wnt Inhibitory Factor-1 Gene in Kidney Cancer
Authors: Kawakami Kazumori , Hirata Hiroshi , Yamamura Soichiro , Kikuno Nobuyuki , Saini Sharanjot , Majid Shahana , Tanaka Yuichiro , Kawamoto Ken , Enokida Hideki , Nakagawa Masayuki , Dahiya Rajvir 
Published: November 2009

AbstractWnt inhibitory factor-1 (WIF-1) has been identified as one of the secreted antagonists that bind Wnt protein. WIF-1 has been described as a tumor suppressor in various types of cancer. However, the molecular function of WIF-1 gene has never been examined in human renal cell carcinoma (RCC). Therefore, we hypothesized that WIF-1 functions as a tumor suppressor gene and overexpression of this gene may induce apoptosis and inhibit tumor growth in RCC cells. Immunohistochemistry and real-time reverse transcription-PCR revealed that WIF-1 was significantly downregulated in RCC samples and RCC cell lines, respectively. Bisulfite sequencing of the WIF-1 promoter region in RCC cell lines showed it to be densely methylated, whereas there was no methylation of WIF-1 promoter in normal kidney. Significant inhibition of cell growth and colony formation in WIF-1–transfected cells compared with controls were observed. WIF-1 transfection significantly induced apoptosis and suppressed in vivo tumor growth. Also, Wnt signaling activity and β-catenin expression were reduced by WIF-1 transfection. In conclusion, this is the first report documenting that the WIF-1 is downregulated by promoter methylation and functions as a tumor suppressor gene by inducing apoptosis in RCC cells. [Cancer Res 2009;69(22):8603–10]