bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of diabetics receiving bare‐metal stents versus drug‐eluting stents
Authors: Ramanath Vijay S. , Brown Jeremiah R. , Malenka David J. , DeVries James T. , Sidhu Mandeep S. , Robb John F. , Jayne John E. , Hettleman Bruce D. , Friedman Bruce J. , Niles Nathaniel W. , Kaplan Aaron V. , Thompson Craig A. 
Published: March 2010

AbstractObjectives: We sought to determine if differences existed in in‐hospital outcomes, long‐term rates of target vessel revascularization (TVR), and/or long‐term mortality trends between patients with diabetes mellitus undergoing percutaneous coronary intervention (PCI) with either a drug‐eluting stent(s) (DES) or a bare metal stent(s) (BMS). Background: Short‐ and long‐term clinical outcomes of patients with diabetes mellitus undergoing PCI with DES versus BMS remain inconsistent between randomized‐controlled trials (RCTs) and observational studies. Methods: Data were collected prospectively on diabetics undergoing PCI with either DES or BMS from January 2000 to June 2008. Demographic information, medical histories, in‐hospital outcomes, and long‐term TVR and mortality trends were obtained for all patients. Results: A total of 1,319 patients were included in the study. Diabetics receiving DES had a significant reduction in index admission MACE compared to diabetics receiving BMS. Using multivariable adjustment, after a mean follow‐up of 2.5 years (maximum 5 years), diabetics who received DES had a 38% decreased risk of TVR compared to diabetics with BMS [HR 0.62 (95% CI: 0.43–0.90)]; diabetics with DES had an insignificant adjusted improvement in long‐term survival compared to diabetics with BMS [HR 0.72 (95% CI: 0.52–1.00)]. These long‐term survival and TVR rates were confirmed using propensity scoring. Conclusions: The use of DES when compared with BMS among diabetics undergoing PCI is associated with significant improvement in long‐term TVR, with an insignificant similar trend in all‐cause mortality. The long‐term results of this observational study are consistent with prior RCTs after adjusting for confounding variables. © 2010 Wiley‐Liss, Inc.
Does on‐ versus off‐hours presentation impact in‐hospital outcomes of ST‐segment elevation myocardial infarction patients transferred to a tertiary care center?
Authors: Gonzalez Manuel A. , Ben‐Dor Itsik , Wakabayashi Kohei , Maluenda Gabriel , Gaglia Michael A. , Hanna Nicholas N. , Delhaye Cedric , Collins Sara D. , Syed Asmir I. , Mitulescu Lavinia P. , Torguson Rebecca , Suddath William O. , Lindsay Joseph , Pichard Augusto D. , Satler Lowell F. , Waksman Ron 
Published: March 2010

AbstractObjectives: To determine whether in‐hospital outcome differs for transferred patients with ST‐segment elevation myocardial infarction (STEMI) presenting during business (ON) hours vs. after (OFF) hours. Background: Door‐to‐device (DTD) time is a prognostic factor in patients with STEMI and is longer during OFF hours. However, the in‐hospital mortality is controversial. Methods: This registry study included 786 consecutive patients with STEMI referred for primary percutaneous coronary intervention to a tertiary care center with an on‐site cardiac catheterization team 24 hrs a day/7 days (24/7) a week. ON hours were defined as weekdays 8 a.m. to 5 p.m., while OFF hours were defined as all other times, including holidays. The primary outcomes were in‐hospital death, reinfarction, and length of stay (LOS). Results: ON hours (29.5%, n = 232) and OFF hours (70.5%, n = 554) groups had similar demographic and baseline characteristics. A significantly higher proportion of patients presenting ON hours had a DTD time ≤120 min compared to OFF hours patients (32.6% vs. 22.1%, P = 0.007). The rates of in‐hospital death (8.2% vs. 6%), reinfarction (0% vs. 1.1%), and mean LOS (5.7 ± 6 vs. 5.7 ± 5) were not significantly different in the ON vs. OFF hours groups, all P = nonsignificant. Conclusion: In a tertiary care center with an on‐site cardiac catheterization team 24/7, there are no differences in in‐hospital outcomes of transferred patients with STEMI during ON vs. OFF hours. © 2010 Wiley‐Liss, Inc.
The generalizability of the effects of retailer e‐service quality dimensions
Authors: Finn Adam 
Published: March 2010

AbstractResearch on the effects of e‐service quality dimensions on customer satisfaction and behavioural intentions has used cross‐sectional data from customer surveys. To draw managerial implications, such research assumes that model parameters estimated across service provider customers apply also to the service providers. The current study collects e‐service data that fully cross respondents with retailer websites. These crossed data are then used to compare the modelled effects of quality dimensions estimated on the confounded data with those estimated across customers and those estimated across websites. The results provide evidence of considerable inconsistency, suggesting that managers should not rely on conclusions drawn from an analysis of variation across customers. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
Important physical parameters of Bi2O3 thin films found by applying several models for optical data
Authors: Condurache‐Bota S. , Rusu G. I. , Tigau N. , Leontie L. 
Published: March 2010

AbstractDifferent optical parameters for thin solid films can be computed as functions of wavelength from the optical transmission and reflection spectra. Subsequently, several models can be tested on the obtained data, in order to check their validity with respect to the materials under study. Moreover, these models offer the possibility to estimate essential physical parameters. Such models are tested within this article for the refraction index and for the real part of the complex dielectric constant, for bismuth trioxide thin films deposited on glass substrates maintained at three different temperatures. Also, the model proposed by Tauc is applied for the absorption spectrum of the same films, in order to determine the type of electronic transition and to estimate the optical energy bandgap. It will be noticed that the optical parameters vary rather significantly with changing substrate temperature, while the structure of the films, as studied by means of X‐ray diffractometry is almost insensitive to this change of deposition parameter. (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Non‐Glycosidically Linked Pseudodisaccharides: Thioethers, Sulfoxides, Sulfones, Ethers, Selenoethers, and Their Binding to Lectins
Authors: Cumpstey Ian , Ramstadius Clinton , Akhtar Tashfeen , Goldstein Irwin J. , Winter Harry C. 
Published: March 2010

AbstractHydrolytically stable non‐glycosidically linked tail‐to‐tail pseudodisaccharides are linked by a single bridging atom remote from the anomeric centre of the constituent monosaccharides. Some such pseudodisaccharides with sulfur or oxygen bridges were found to act as disaccharide mimetics in their binding to the Banana Lectin and to Concanavalin A. A versatile synthetic route to a small library of such compounds is described.
CE‐ESI‐MS/MS as a rapid screening tool for the comparison of protein–ligand interactions
Authors: Hoffmann Thomas , Martin Markus M. 
Published: March 2010

AbstractIn drug development, the combinatorial synthesis of drug libraries is common use, therefore efficient tools for the characterization of drug candidates and the extent of interaction between a drug and its target protein is a central question of analytical interest. While biological activity is tested today by enzyme assays, MS techniques attract more and more attention as an alternative for a rapid comparison of drug–target interactions. CE enables the separation of proteins and drug–enzyme complexes preserving their physiological activity in aqueous media. By hyphenating CE with ESI‐MS/MS, the binding strength of enzyme inhibitors can be deduced from MS/MS experiments, which selectively release the inhibitor from the drug–target complex after CID. In this study, α‐chymotrypsin (CT), a serine protease, was chosen as a model compound. Chymostatin is a naturally occurring peptide aldehyde binding to CT through a hemiacetal bond and electrostatic interaction. First, a CE separation was developed, which allows the analysis of α‐CT and a chymotrypsin–chymostatin complex under MS‐compatible conditions. The use of neutral‐coated CE capillaries was mandatory to reduce analyte–wall interactions. ESI‐quadrupole ion trap‐MS was worked out to demonstrate the selective drug release after CID. Fragmentation of the drug–enzyme complex was monitored in dependence from the excitation energy in the ion trap, leading to the V50 voltage that enables 50% complex fragmentation as a reference value for chymotrypsin–chymostatin complex. A stable CE‐ESI‐MS/MS setup was established, which preserves the drug–enzyme complexes during ionization–desolvation processes. With this optimized setup, different CT inhibitors could be investigated and compared.
Simulation of oscillatory flow in an aortic bifurcation using FVM and FEM: A comparative study of implementation strategies
Authors: Gohil Trushar , McGregor Robert H. P. , Szczerba Dominik , Burckhardt Kathrin , Muralidhar Krishnamurthy , Székely Gábor 
Published: March 2010

AbstractCardiovascular diseases are one of the major causes of long‐term morbidity and mortality in human beings. The nearly epidemic increase in prevalence of such diseases poses a serious threat to public health and calls for efficient methods of diagnosis and treatment. Non‐invasive diagnostic procedures such as MRI are often used in this context; however, these are limited in terms of spatial and temporal resolution and do not provide information on time‐dependent pressures and wall shear stresses—key quantities considered to be partially responsible for the formation and development of related pathologies.The present study is concerned with the numerical simulation of oscillatory flow through the abdominal aortic bifurcation. Computational fluid dynamics simulation of oscillatory flow in a branched geometry at high Reynolds numbers poses considerable challenges. The present study reports a detailed comparison of simulations performed with a finite volume and a finite element method, two approaches with significant differences in their discretization strategy, treatment of boundary conditions and other numerical aspects. Both solvers were parallelized, using loop parallelization of the BiCGStab linear solver for the finite volume and domain decomposition based on the Schur complement method for the finite element technique. The experience gained with these two approaches for the solution of flow in a bifurcation forms the focus of this study. Although similar results were obtained for both methods, the computation time required for convergence was found to be significantly smaller for the finite element approach. Copyright © 2010 John Wiley & Sons, Ltd.
Quantitative cell bioimaging using gold‐nanoshell conjugates and phage antibodies
Authors: Khanadeev Vitaly A. , Khlebtsov Boris N. , Staroverov Sergey A. , Vidyasheva Irina V. , Skaptsov Alexander A. , Ileneva Ekaterina S. , Bogatyrev Vladimir A. , Dykman Lev A. , Khlebtsov Nikolai G. 
Published: March 2010

AbstractThe authors describe a quantitative evaluation of the efficacy of cell labeling with plasmon‐resonant light‐scattering nanoparticles used as contrast agents for dark‐field microscopy imaging. The experimental model is based on the biospecific labeling of pig embryo kidney (SPEV) cells with primary phage antibodies, followed by the dark‐field microscopic visualization using conjugates of silica/gold nanoshells with secondary rabbit antiphage antibodies. To quantify nanoparticle binding, the authors introduce the labeling‐efficacy factor (LEF) which is equal to the ratio of the bound‐particle pixels per cell to the total number of pixels occupied by the cell. The LEF is calculated by an imaging‐analysis algorithm based on the freely available ImageJ Java‐based processing code. In terms of the LEF, a distinct difference was found between intact, nonspecifically labeled, and biospecifically labeled cells. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Low‐temperature glycol methacrylate resin embedding method: A protocol suitable for bone marrow immunohistochemistry, PCR, and fish analysis
Authors: Zhang Qiguo , Wang Jing , Wu Hongyan , Zhang Le , Zhou Jinyong , Ye Qing , Shao Xiaoyan , Guan Chaoyang , Xu Jingyan , Yang Yonggong , Zhou Rongfu , Ouyang Jian 
Published: March 2010

AbstractMolecular analyses such as fluorescence in situ hybridization (FISH) and polymerase chain reaction (PCR) are demanded to improve diagnostic accuracy in addition to immunohistopathology of bone marrow (BM) trephine specimens. Conventional BM embedding method needs decalcification, and its procedure may impair tissue morphology and DNA quality. Here, we report an undecalcified method by which glycol methacrylate resin is polymerized at low temperature (4°C). Using this method, BM enzyme activity and antigenic determinants are well preserved, and moreover, DNA extracted from plastic embedding sections is suitable for PCR amplification and sequencing, FISH analysis can be well done because of the DNA integrity of BM sections. If working with BM trephine specimen, our protocol offers the possibility to combine superior morphology with modern molecular analysis. Microsc. Res. Tech. 73:1067–1071, 2010. © 2010 Wiley‐Liss, Inc.
Annual precipitation reconstruction since AD 775 based on tree rings from the Qilian Mountains, northwestern China
Authors: Zhang Yong , Tian Qinhua , Gou Xiaohua , Chen Fahu , Leavitt Steven W. , Wang Yousheng 
Published: March 2010

AbstractA millennium‐long tree‐ring‐width chronology from the middle Qilian Mountains in northwestern China has been used to reconstruct annual precipitation variation (from the prior August to current July) since AD 775. The reconstruction explains 37.8% of variance of the observed data. Based on the mean and standard deviation of the reconstructed series, several prolonged severe dry and wet periods were indentified: drought spells in AD 1144–1154 (11 years) and 1925–1932 (8 years) and wet spells in AD 985–999 (15 years), 1089–1097 (9 years) and 1979–1991 (12 years). Both multi‐taper spectral analysis (MTM) and wavelet analysis suggest that periods of the reconstructed precipitation are consistent with those associated with the Asian Summer Monsoon and perhaps solar activity. Copyright © 2010 Royal Meteorological Society
Electrostatic Assembly of Poly(ethylene glycol) Nanotubes
Authors: Jang Woo‐Sik , Saito Tomonori , Hickner Michael A. , Lutkenhaus Jodie L. 
Published: March 2010

AbstractPoly(ethylene glycol) (PEG)‐based films, nanotubes, and nanotube arrays were successfully made using layer‐by‐layer (LbL) assembly ion‐containing PEO derivatives on porous templates and planar substrates. PEG nanotubes are challenging to produce because PEG dissolves into solutions and solvents used during nanotube processing, but our techniques circumvent the issue. Nanotube dimensions were verified using microscopy and the average observed diameter was 155 nm. The PEG‐based structures showed remarkable stability in water, salt water, and sodium hydroxide solution.magnified image
Medizinische Chemie der GLP‐1‐Analoga und DPP‐IV‐Inhibitoren. Das Inkretinsystem als Wirkstoff‐Target
Authors: Zettl Heiko , Steinhilber Dieter 
Published: March 2010

AbstractDie mittlerweile als “Epidemie des 21. Jahrhunderts” bezeichnete Volkskrankheit Typ 2 Diabetes mellitus (T2DM) zählt mehr denn je zu den großen Herausforderungen bei der Entwicklung neuer Arzneistoffe. Die beiden jüngsten Arzneistoffklassen – Analoga des Glucagon‐like peptide‐1 (GLP‐1) und Inhibitoren der Dipeptidyl‐Peptidase IV (DPP IV) – sollen aufgrund ihres pharmakologischen Ansatzes klassische Antidiabetika‐assoziierte Nebenwirkungen wie Hypoglykämien und Gewichtszunahme umgehen.
Neue Wirkstoffklassen in der Pipeline. Neues in der Therapie des Diabetes mellitus
Authors: Steri Ramona , Schubert‐Zsilavecz Manfred 
Published: March 2010

AbstractDie Pharmakotherapie des Diabetes mellitus hat in der letzten Dekade kontinuierlich zugenommen. Die Insulinverordnungen haben sich in diesem Zeitraum verdoppelt. Die Metformin‐Verordnungen sind mehr als dreifach angestiegen, wohingegen die der Sulfonylharnstoffe seit 1999 in etwa konstant geblieben sind. Glitazone zeigen nur mehr geringfügige Zuwachsraten, da insbesondere neuere Studien Hinweise auf ein erhöhtes Herzinfarkt‐ und Frakturrisiko gezeigt haben.
Amadacyclin – ein neues Tetracyclin‐Antibiotikum in der Pipeline
Authors: Schmitz Jens , Holzgrabe Ulrike 
Published: March 2010

AbstractKürzlich gab Novartis bekannt, die weltweiten Distributionsrechte an dem Tetracyclin‐Derivat Amadacyclin (PTK0796) von Paratek Pharmaceuticals erworben zu haben. Amadacyclin ist ein partialsynthetisches Derivat von Minocyclin und aufgrund seiner Substitution in Position 9 in Ring D mit einer Dimethylpropylaminomethyl‐Gruppe der erste Vertreter einer vermeintlich neuen Gruppe von Tetracyclinen, den “Aminomethylcyclinen”.
Der Ball ist nicht immer rund. Gleiten, Rollen und Haften bei Ballreflexionen
Authors: Thaller Sigrid , Mathelitsch Leopold 
Published: March 2010

AbstractDas Reflexionsverhalten von Bällen ist physikalisch gesehen sehr unterschiedlich. Je nach Material, Spin und Einfallswinkel kommt es zu Gleit‐ oder Rollbewegungen. In vielen Fällen kann man auch ein teilweises oder vollständiges Haften des Balles beobachten. Durch die Verformung des Balles während der Stoßbewegung können Schwingungen auftreten. Sie verursachen eine mehrmalige Richtungsänderung der Reibungskräfte. Bei gleichem Einfallswinkel und gleichem Spin kann je nach Materialeigenschaften und Reflexionsart eine Verstärkung der Drehung oder sogar eine Umkehrung des Drehsinns auftreten.
Bewegte Bilder aus dem Nanokosmos. Der Freie‐Elektronen‐Laser European XFEL
Authors: Tschentscher Thomas , Schwarz Andreas S. , Rathje Dirk 
Published: March 2010

AbstractAm European XFEL in Hamburg sollen ultrakurze Röntgenlaserblitze erzeugt werden – 30000‐mal in der Sekunde und mit einer Leuchtstärke, die milliardenfach höher ist als die der besten Röntgenstrahlungsquellen herkömmlicher Art. Dazu werden in einem Linearbeschleuniger Elektronen in Paketen auf hohe Energien gebracht und anschließend durch spezielle Magnetanordnungen (Undulatoren) gelenkt. Dabei senden die Teilchen Licht aus, das sich immer mehr verstärkt, bis schließlich ein extrem kurzer und intensiver Röntgenblitz entsteht. Mehrere Experimentierstationen ermöglichen parallel verlaufende Untersuchungen. Der European XFEL wird von einer eigenständigen Forschungsorganisation, der European XFEL GmbH, realisiert, die eng mit DESY und internationalen Partnern zusammenarbeitet und soll 2014 in Betrieb gehen.
Photoredox reaction of functionalized polyelectrolytes
Authors: Morishima Yotaro , Nozakura Shun‐Ichi 
Published: March 2010

AbstractThe electron transfer reaction from excited phenanthrene to acceptors was shown to be modified markedly when the phenanthrene unit was covalently linked to polyelectrolytes. (1) Such functionalized polyelectrolytes were shown to form hydrophobic microdomains in aqueous solution. (2) Uptake of amphiphilic acceptor substrates by the microdomain was demonstrated and was shown to accelerate the forward electron transfer reaction. (3) The electrostatic effect of microdomain was shown to effect the photoinduced charge separation. (4) The electrostatic potential of the microdomain was estimated to be comparable with that of surfactant micelles.
Determination of the sequence distribution and ionization constant of poly(acrylic acid‐co‐vinylamine) by C‐13 NMR
Authors: Chang C. , Muccio D. D. , Pierre T. St. 
Published: March 2010

AbstractThree copolymers of poly(acrylic acid‐co‐vinylamine) containing 12% (SP12). 30% (SP30), and 52% (SP52) amino groups were synthesized from poly(acrylic acid) by means of the Schmidt reaction. These copolymers were analyzed by C‐13 NMR and the results compared wiih the previously analyzed homopolymers. The various comonomer sequence distributions were identified by means of peak areas. It was determined thai (1) the reactivity was not significantly influenced by the triad taciicity of the parent poly(acrylic acid), (2) the final copolymer is characterized by an essentially alternating sequence, and (3) there is extensive lactam formation between neighboring carboxyl and amino groups. In terms of nearest neighbor effects, the relative rales of amine formation are k1/k0 ≈ 0.3 and k2/k0 ≈ 0. A C‐13 NMR pH titration of SPI2 showed that the carboxyl group with a neighboring amino group is more acidic man a carboxyl group flanked by two carboxyl groups.
Determination of polymer‐polymer interaction parameters of incompatible monodisperse and polydisperse polymers in solution
Authors: Narasimhan Venkataraman , Huang Robert Y. M. , Burns Charles M. 
Published: March 2010

AbstractEquilibrium phase studies were carried out on the ternary system of polystyrene‐poly butadiene‐toluene at 23°C and 1 atm. Narrow and broad molecular weight distribution (MWD) samples of polystyrene and polybutadiene were employed, and their binodal curves were established. Expressions were derived to calculate X2i values for both monodisperse (narrow MWD) and polydisperse polymers. Typical interaction parameters determined from (lie experimental data are presented. It is concluded that monodisperse expressions can be used for polydisperse polymers using the number‐average molecular weight.
Synthesis and enhanced green photoluminescence emission from BCT ZnS nanocrystals
Authors: Tiwary C. S. , Kumbhakar P. , Mondal A. K. , Mitra A. K. 
Published: March 2010

AbstractBody‐centered‐tetragonal (BCT) ZnS nanocrystals have been synthesized, for the first time to the best of our knowledge, by using the chemical coprecipitation method at higher synthesis temperatures of 65 and 95 °C. It is confirmed from X‐ray diffraction (XRD) studies that in the high‐temperature‐synthesized samples, cubic and BCT phases coexist, in contrast to the room‐temperature‐synthesized sample, which consists of only cubic phase with sizes of the particles lying between 2 and 3 nm. The sizes of BCT phase nanocrystals are bigger than those of cubic phase of ZnS. The presence of BCT phase of ZnS in the samples is increased from 40 to 90% when the temperature of synthesis is increased from 65 to 95 °C. The nanocrystalline nature and UV–Vis absorption characteristics of the prepared samples have been studied with a transmission electron microscope (TEM) and a UV–Visible spectrophotometer, respectively. The room‐temperature‐synthesized ZnS sample shows photoluminescence (PL) emission in the blue region with multiple peaks, whereas the high‐temperature‐synthesized samples show PL emissions in the visible region. The Gaussian fittings of the measured PL spectra shows that three PL peaks at 429, 477, and 525 nm are appeared in the 65 °C sample and two peaks at 491 and 540 nm appear in the 95 °C sample with the enhanced PL intensity of the green peak at 540 nm.
Plasmonic resonances in nanostructured gold/polymer surfaces by colloidal lithography
Authors: Giudicatti Silvia , Valsesia Andrea , Marabelli Franco , Colpo Pascal , Rossi François 
Published: March 2010

AbstractWe investigate nanostructured surfaces consisting of a hexagonal lattice of polymeric pillars embedded in a gold matrix. These systems are prepared by a new fabrication technique based on plasma assisted deposition and colloidal lithography. A complete characterization of such surfaces is performed by angle resolved reflectance and transmittance measurements. Both delocalized and localized plasmonic modes can be identified: their reciprocal interplay allows to observe spectral features and to detect refractive index changes related to one of the sample interfaces by measurements performed with a light beam incident from the opposite side. This intriguing behaviour, together with ease of use and low cost of the deposition procedure, make this kind of nanostructures particularly interesting in biosensing applications.