bluuebunny/crossref_metadata_2025_split huggingface dataset:
NIK Prevents the Development of Hypereosinophilic Syndrome-like Disease in Mice Independent of IKKα Activation
Authors: Häcker Hans , Chi Liying , Rehg Jerold E. , Redecke Vanessa 
Published: April 2012

Abstract
Immune cell-mediated tissue injury is a common feature of different inflammatory diseases, yet the pathogenetic mechanisms and cell types involved vary significantly. Hypereosinophilic syndrome (HES) represents a group of inflammatory diseases that is characterized by increased numbers of pathogenic eosinophilic granulocytes in the peripheral blood and diverse organs. On the basis of clinical and laboratory findings, various forms of HES have been defined, yet the molecular mechanism and potential signaling pathways that drive eosinophil expansion remain largely unknown. In this study, we show that mice deficient of the serine/threonine-specific protein kinase NF-κB–inducing kinase (NIK) develop a HES-like disease, reflected by progressive blood and tissue eosinophilia, tissue injury, and premature death at around 25–30 wk of age. Similar to the lymphocytic form of HES, CD4+ T cells from NIK-deficient mice express increased levels of Th2-associated cytokines, and eosinophilia and survival of NIK-deficient mice could be prevented completely by genetic ablation of CD4+ T cells. Experiments based on bone marrow chimeric mice, however, demonstrated that inflammation in NIK-deficient mice depended on radiation-resistant tissues, implicating that NIK-deficient immune cells mediate inflammation in a nonautonomous manner. Surprisingly, disease development was independent of NIK’s known function as an IκB kinase α (IKKα) kinase, because mice carrying a mutation in the activation loop of IKKα, which is phosphorylated by NIK, did not develop inflammatory disease. Our data show that NIK activity in nonhematopoietic cells controls Th2 cell development and prevents eosinophil-driven inflammatory disease, most likely using a signaling pathway that operates independent of the known NIK substrate IKKα.
Coordination intraorganisationnelle : une approche conventionnelle des pratiques de stock dans la banque de détail
Authors: Maymo Vincent 
Published: April 2012

Dans les organisations bancaires, la pratique de stockage des dossiers pose deux questions principales : la performance du management dans les sociétés de services d’une part et l’efficacité des mécanismes de coordination intra-organisationnelle d’autre part. Le concept de convention est mobilisé pour répondre au besoin de cohérence entre les dimensions cognitives et socio-techniques de la coordination et ses objectifs. Nous utilisons une grille de lecture pour analyser le processus de prêts immobiliers en banque de détail. L’opérationnalisation de cette grille met en évidence la contribution de la théorie des conventions à la performance organisationnelle et initie une typologie des conventions de comprendre l’origine des défaillances potentielles de coordination.
Quand l’édition devient terroriste : solidarité intellectuelle chez Jean Grave et Octave Mirbeau à la fin du xixe siècle en France
Authors: Moisan Justin 
Published: April 2012

Le réseautage qui s’effectue dans les différents milieux anarchistes de la fin du xixe siècle fait montre de la structuration du mouvement libertaire de l’époque. À ce titre, les liens qui se tissent entre les anarchistes militants et les milieux littéraires et artistiques présentent des formes d’organisation anarchiste. La collaboration entre l’éditeur du journal anarchiste La Révolte Jean Grave et l’écrivain et journaliste de renom Octave Mirbeau représente un bon exemple du réseau qui s’élabore ainsi.
À travers divers moments marquants de leur coopération autour des pratiques éditoriales (journaux et livres), cet article montre de quelle manière leur engagement anarchiste participe au déploiement du mouvement libertaire, qui connaît, au cours de cette période, de nombreux bouleversements. À partir de ce cas, il s’agit de cerner la signification et le rôle de la solidarité, particulièrement chez les artisans du journal et du livre, qui se manifeste dans le développement de l’anarchisme.
Le voyage de Dionysos dans la Grèce après 1975 ou Les épigones modernes de la dramaturgie grecque ancienne
Authors: Diamantakou-Agathou Kaiti 
Published: April 2012

L’intérêt se focalise sur les pièces grecques modernes qui « dialoguent » avec des drames antiques, tragiques ou comiques, à thématique correspondante, à travers une « mémoire généalogique » qui semble survivre, manifeste ou latente, dans l’écriture théâtrale depuis l’antiquité jusqu’à nos jours. Ce « dialogue homogène », maintenu entre les traitements dramatiques grecs anciens et modernes des mythes communs, nous permettra de constater à plusieurs niveaux (formes, contenus, motivations, modes, fonctions, etc.) la tension et l’extension de l’« influence » et de l’« envergure » diachronique du mythe ancien, sous toutes ses formes esthétiques et codifications théâtrales possibles.
Molière en Grèce
Authors: Stasinopoulou Maria 
Published: April 2012

Dans le cas des comédies de Molière représentées par des troupes helléniques, nous pourrons constater deux grandes tendances : les représentations d’avant-garde et classiques. Les unes focalisent sur le conflit intérieur du personnage ; les autres soit sur le jeu corporel, soit sur les aspects politiques et idéologiques de l’intrigue. Par ailleurs, le point commun des mises en scène ci-dessus est le respect du texte théâtral par les concepteurs de la représentation. Cette caractéristique nous permet de classifier les pièces étudiées selon la typologie proposée par Patrice Pavis. Ladite typologie a comme point de départ la fidélité au texte théâtral. Notre objectif est de constater de quelle façon la théâtralisation des personnages et des situations de ces pièces contribue à la transformation du texte en spectacle.
Dramaturgies marionnettiques
Authors: Sermon Julie 
Published: April 2012

Depuis le tournant du XXe siècle, la marionnette n’est plus seulement un instrument théâtral spécifique, mais un modèle ou un idéal esthétique, un régime d’énonciation et de représentation alternatif qui, de façon explicite ou latente, continue d’inspirer les auteurs quelle que soit la nature des interprètes auxquels ils destinent officiellement leurs textes. Cet article se propose de déterminer quelles sont les caractéristiques du « marionnettique » et quelles sont leurs conséquences pour la dramaturgie et le jeu de l’acteur.
Adeno‐Associated Viral Vectors for Anterograde Axonal Tracing with Fluorescent Proteins in Nontransgenic and Cre Driver Mice
Authors: Harris Julie A. , Wook Oh Seung , Zeng Hongkui 
Published: April 2012

AbstractHarnessing the natural ability of viruses to infect post‐mitotic cells such as neurons has provided an explosion of new methods to manipulate and reconstruct neural circuits in vivo. Here we describe the use of recombinant adeno‐associated viral vectors (rAAV) for axonal tract tracing in nontransgenic and transgenic Cre driver mice. Two protocols are presented for stereotactic‐guided placement of rAAV vectors into the live mouse brain using iontophoretic or nanoliter pressure injections. The methods discussed here will result in expression of fluorescent proteins in cell bodies, dendrites, and axons in targeted neurons, and can be easily adapted to address various experimental questions. Curr. Protoc. Neurosci. 59:1.20.1‐1.20.18. © 2012 by John Wiley & Sons, Inc.
Thermal Treatment Optimization of Electrodeposited Hydroxyapatite Coatings on Ti6Al4V Substrate
Authors: Drevet Richard , Fauré Joël , Benhayoune Hicham 
Published: April 2012

AbstractThermal behavior of electrodeposited hydroxyapatite (HAP) coating on a titanium alloy (Ti6Al4V) is investigated in order to optimize the heat treatment conditions for this prosthetic material. The synthesized coatings are annealed in air atmosphere at 400, 600, 800, and 1000 °C, and then characterized by X‐ray diffraction (XRD) and selected area electron diffraction (SAED) for structure and phases analysis. Scanning and transmission electron microscopy associated to energy dispersive X‐ray microanalysis (SEM‐EDXS and STEM) are used for morphology and composition analysis. The results show that when the electrodeposited coating is annealed at temperatures greater than 600 °C, a well‐crystallized HAP is obtained with a notable change of its morphology. However, at these temperatures the surface of Ti6Al4V alloy (uncoated zones of the implant) is deteriorated by the formation of a thick surface oxide layer. Therefore, we limit the heat treatment temperature for the electrodeposited coatings on a Ti6Al4V alloy at 550 °C. At this optimized temperature it is demonstrated that the link between the coating and the substrate is improved and the crystallinity of the coating is controlled which make it well bioactive.
Synthesis and characterization of polyethylene oxide and nylon‐6 copolymer in a fiber form
Authors: Rwei Syang‐Peng , Tseng Yu‐Chi , Lin Wei‐Peng 
Published: April 2012

AbstractA series of poly(ethylene oxide) (PEO) and nylon‐6 copolymers were synthesized through condensation reactions. The rheology of the prepared copolymers was tested using a capillary flow rheometer. The molar mass was investigated by performing basic analyses such as relative viscosity, gel permeation chromatograph, and amino‐end group analysis. Their thermal properties were examined by differential scanning calorimetry, and the crystalline structure was determined using wide‐angle X‐ray diffraction. The results obtained from partially oriented yarn indicated a dramatically conversion from the γ form to the α form. Following the draw texture process, the α form dominated all draw textured yarn. Once the segments of PEO were introduced into the nylon‐6 backbone, the moisture regain and qmax (warm/cool feeling) of the fabrics was enhanced remarkably. The surface resistivity of fabrics improved with increasing PEO content, which is mainly due to water absorption. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Thermal conductivity and morphology of silver‐filled multiwalled carbon nanotubes/polyimide nanocomposite films
Authors: Tseng I‐Hsiang , Lin Hsin‐Chuan , Tsai Mei‐Hui , Chen Dong‐Sen 
Published: April 2012

AbstractA facile methodology has been developed to synthesize silver‐filled multiwalled carbon nanotubes (S‐MWNTs)‐polyimide (PI) nanocomposites with high thermal conductivity for applications in flexible printed circuits or buried film capacitors, requiring efficient heat dissipation. MWNTs functioned as modules to facilitate the distribution of Ag particles within PI matrix. The intercalation of Ag within MWNTs was performed using capillary action upon mixing AgNO3 solution with PI precursor and followed by calcinations to reduce the ionic silver to Ag. The existence of Ag in the PI nanocomposites was observed from transmission electron microscope images and verified with the energy‐dispersive X‐ray spectrometer. Homogeneous dispersion of SMWNTs in PI matrix and strong interaction between S‐MWNTs and PI were also suggested by SEM cross‐section images. The thermal conductivity of S‐MWNT/PI nanocomposite was a function of the content of S‐MWNTs in PI matrix. The PI nanocomposite containing 1.5 wt % of S‐MWNTs (S‐MWNT/PI‐1.5) exhibited the highest thermal conductivity, 0.37 W/mK. A decrease in thermal conductivity was observed while the surface roughness of the nanocomposite was higher than 1 μm owing to the high content of S‐MWNT in PI. In addition, the modified MWNTs improved flexibility of the PI matrix. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Study on properties of gel polymer electrolytes based on ionic liquid and amine‐terminated butadiene‐acrylonitrile copolymer chemically crosslinked by polyhedral oligomeric silsesquioxane
Authors: Li Ming , Ren Wentan , Zhang Yong , Zhang Yinxi 
Published: April 2012

AbstractBased on amine‐terminated butadiene‐acrylonitrile copolymer chemically crosslinked by epoxycyclohexyl polyhedral oligomeric silsesquioxane (POSS), a novel gel polymer electrolyte (GPE) were prepared by introducing one ionic liquid and LiClO4 into the polymer framework. Fourier transform infrared spectroscopy, field emission scanning electron microscopy, and X‐ray diffraction analysis confirmed the interaction between the ionic liquid and LiClO4, and this interaction contributes to dissolving LiClO4 salt and increasing the ionic conductivity of GPE. Less content of POSS leads to higher ionic conductivities but lower gel content and modulus. The maximum ionic conductivity of 2.0 × 10−4 S cm−1 (30°C) was achieved and an Arrhenius‐type relationship between ionic conductivities and temperatures could be detected over the investigated temperature range. The generated GPE exhibited good electrochemical stability to 4 V from cyclic voltammogram tests, which made this kind of GPE a promising candidate for rechargeable lithium batteries. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Effect of temperature on dynamic rheological properties of uncured rubber materials in both the linear and the nonlinear viscoelastic domains
Authors: Leblanc Jean L. 
Published: April 2012

AbstractInvestigating how rubber materials are affected by strain and strain rate (or frequency) in the room‐to‐curing temperature range allows to fully characterize them not only with respect to their processing behavior but also in view of their likely performances after vulcanization. Using a closed cavity dynamic rheometer, the adequate test protocols and data treatment, three gum elastomers, and three carbon black filled compounds were investigated in the 60–180°C range. The article describes the test protocol and the associated data treatment that were developed to document the effects of strain and temperature in both the linear and the nonlinear domains. Complex modulus G* and third relative torque harmonic variations with strain amplitude and temperature are reported and discussed in details. A set of relatively simple mathematical equations are demonstrated to offer the possibility to summarize large quantities of experimental data through a limited number of parameters whose physical meaning can be explained with respect to known aspects of polymer and rubber sciences. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Vestigial Tooth Anatomy and Tusk Nomenclature for Monodon Monoceros
Authors: Nweeia Martin T. , Eichmiller Frederick C. , Hauschka Peter V. , Tyler Ethan , Mead James G. , Potter Charles W. , Angnatsiak David P. , Richard Pierre R. , Orr Jack R. , Black Sandie R. 
Published: April 2012

AbstractNarwhal tusks, although well described and characterized within publications, are clouded by contradictory references, which refer to them as both incisors and canines. Vestigial teeth are briefly mentioned in the scientific literature with limited descriptions and no image renderings. This study first examines narwhal maxillary osteoanatomy to determine whether the erupted tusks are best described as incisiform or caniniform teeth. The study also offers evidence to support the evolutionary obsolescence of the vestigial teeth through anatomic, morphologic, and histologic descriptions. Examination of 131 skull samples, including 110 museum skull specimens and 21 harvested skulls, revealed the erupted tusks surrounded by maxillary bone over the entire length of their bone socket insertion, and are thus more accurately termed caniniform or canine teeth. The anatomy, morphology, and development of vestigial teeth in five skull samples are more fully described and documented. Vestigial tooth samples included 14 embedded pairs or individual teeth that were partially exposed or removed from the maxillary bone. Their location was posterior, ventral, and lateral to the tusks, although male vestigial teeth often exfoliate in the mouth lodging between the palatal tissue and underlying maxillary bone. Their myriad morphologies, sizes, and eruption patterns suggest that these teeth are no longer guided by function but rather by random germ cell differentiation and may eventually cease expression entirely. The conclusions reached are that the narwhal tusks are the expression of canine teeth and that vestigial teeth have no apparent functional characteristics and are following a pattern consistent with evolutionary obsolescence. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
Positron Emission Tomography Molecular Imaging of Dopaminergic System in Drug Addiction
Authors: Hou Haifeng , Tian Mei , Zhang Hong 
Published: April 2012

AbstractDopamine (DA) is involved in drug reinforcement, but its role in drug addiction remains unclear. Positron emission tomography (PET) is the first technology used for the direct measurement of components of the dopaminergic system in the living human brain. In this article, we reviewed the major findings of PET imaging studies on the involvement of DA in drug addiction, especially in heroin addiction. Furthermore, we summarized PET radiotracers that have been used to study the role of DA in drug addiction. To investigate presynaptic function in drug addiction, PET tracers have been developed to measure DA synthesis and transport. For the investigation of postsynaptic function, several radioligands targeting dopamine one (D1) receptor and dopamine two (D2) receptor are extensively used in PET imaging studies. Moreover, we also summarized the PET imaging findings of heroin addiction studies, including heroin‐induced DA increases and the reinforcement, role of DA in the long‐term effects of heroin abuse, DA and vulnerability to heroin abuse and the treatment implications. PET imaging studies have corroborated the role of DA in drug addiction and increase our understanding the mechanism of drug addiction. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
2′‐Chloro‐4′‐aminoflavone Derivatives Selectively Targeting Hepatocarcinoma Cells: Convenient Synthetic Process, G2/M Cell Cycle Arrest and Apoptosis Triggers
Authors: Jin Feng , Zhang Nannan , Tan Chunyan , Gao Dan , Zhang Cunlong , Liu Feng , Chen Zhe , Gao Chunmei , Liu Hongxia , Li Shangfu , Jiang Yuyang 
Published: April 2012

AbstractA series of 2′‐chloro‐4′‐nitroflavone and 2′‐chloro‐4′‐aminoflavone derivatives were synthesized by a convenient synthetic process. The in vitro anti‐proliferation ability of these compounds was evaluated against hepatocarcinoma cells (HepG2), breast adenocarcinoma cells (MCF‐7), and human chronic myelogenous leukemia cells (K562). Most of synthetic compounds possessed notable anti‐proliferation activity against HepG2 cells and little activity against MCF‐7 cells and K562 cells. In particular, compounds 4c and 4e exhibited high anti‐proliferation activity against HepG2 cells with IC50 at about 2.0 µM. Further toxicity screening toward normal human hepatocytes indicated that some compounds had low toxicity against normal liver cells, among which 4e displayed very weak effects on QSG7701 and HL7702 cells, with IC50 values >100 and 50 µM, respectively. Compound 4c, with the best anti‐proliferation activity in amino‐substituted flavones (IC50 = 2.0 µM), was selected for further evaluation of its effects on apoptosis and the cell cycle. HepG2 cells were exposed to this compound at 10 µM, which induced nuclear disassembly and DNA fragmentation. Flow cytometry analysis suggested that the population of apoptotic cells greatly increased in the 4c‐treated HepG2 cells, and the cell cycle was arrested at the G2/M phase.
Design and One‐Pot and Microwave‐Assisted Synthesis of 2‐Amino/5‐Aryl‐1,3,4‐oxadiazoles Bearing a Benzimidazole Moiety as Antioxidants
Authors: Kerimov İlgar , Ayhan‐Kılcıgil Gülgün , Özdamar Elçin Deniz , Can‐Eke Benay , Çoban Tülay , Özbey Süheyla , Kazak Canan 
Published: April 2012

AbstractIn this study, two new series of 2‐amino‐1,3,4‐oxadiazoles and 5‐aryl‐1,3,4‐oxadiazoles carrying a benzimidazole moiety were synthesized. The antioxidant properties of these compounds were investigatedin vitroby the determination of the microsomal NADPH‐dependent inhibition of lipid peroxidation levels (LP), the microsomal ethoxyresorufinO‐deethylase activity (EROD), and DPPH radical scavenger effects. Among the tested compounds, 2‐[(2‐(4‐chlorophenyl)‐1H‐benzo[d]imidazole‐1‐yl)methyl]‐5‐(4‐fluorophenyl)‐1,3,4‐oxadiazole (9) was found to be the most active compound in all threein vitrosystems.
Comparative performance analysis of European airports by means of extended data envelopment analysis
Authors: Suzuki Soushi , Nijkamp Peter , Pels Eric , Rietveld Piet 
Published: April 2012

SUMMARYData envelopment analysis (DEA) has become an established approach for analyzing and comparing efficiency results of corporate organizations or economic agents. It has also found wide application in comparative studies on airport efficiency. The standard DEA approach to comparative airport efficiency analysis has two feeble elements, viz. a methodological weakness and a substantive weakness. The methodological weakness originates from the choice of uniform efficiency improvement assessment, whereas the substantive weakness in airport efficiency analysis concerns the insufficient attention for short‐term and long‐term adjustment possibilities in the production inputs determining airport efficiency.The present paper aims to address both flaws by doing the following: (i) designing a data‐instigated distance friction minimization (DFM) model as a generalization of the standard Banker–Charnes–Cooper model with a view to the development of a more appropriate efficiency improvement projection model in the Banker–Charnes–Cooper version of DEA and (ii) including as factor inputs also lumpy or rigid factors that are characterized by short‐term indivisibility or inertia (and hence not suitable for short‐run flexible adjustment in new efficiency stages), as is the case for runways of airports. This so‐called fixed factor case will be included in the DFM submodel of the DEA. This extended DEA—with a DFM and a fixed factor component—will be applied to a comparative performance analysis of several major airports in Europe. Finally, our comparative study on airport efficiency analysis will be extended by incorporating also the added value of the presence of shopping facilities at airports for their relative economic performance. Copyright © 2012 John Wiley & Sons, Ltd.
Untersuchungen zum Einfluss der Klebstoffart auf den Diffusionswiderstand von Holzverklebungen
Authors: Volkmer Thomas , Schmidt Jon‐Anton , Kranitz Katalin , Niemz Peter 
Published: April 2012

AbstractAn reinen Klebstofffilmen aus verschiedenen Klebstoffen (PVA, PUR, UF, MUF, EPI, Knochenleim) und an verklebten Holzlamellen mit einer mittigen Klebefuge wurde der Diffusionswiderstand im Dry‐ und im Wet‐Cup‐Verfahren nach DIN EN ISO 12572 bestimmt. Es wurden deutliche Unterschiede im Diffusionswiderstand zwischen den einzelnen Klebstoffarten gemessen. Der Diffusionswiderstand der Klebstofffilme war wesentlich höher als der der Verklebungen, was auf die entsprechenden Abbindemechanismen und die Eindringung der Klebstoffe in das Substrat zurückzuführen ist. Die Klebefugen der geprüften Systeme PVAc, EPI und 1K‐PUR erwiesen sich im Vergleich als sehr diffusionsdicht, was bei einer bauphysikalischen Bewertung von verklebten Holzelementen zu berücksichtigen ist.Investigations of the water vapor resistance of glued wood joints depending on the type of adhesive. The water vapor resistance was measured at pure adhesive layers (PVA, PUR, UF, MUF, EPI, bone glue) and at glued wood lamellas according to DIN EN ISO 12572 using the dry‐cup and the wet‐cup‐procedure. Clear differences of the water vapor resistance between the different adhesive variants could be analyzed. The resistance of the pure adhesive layers was considerable higher than the resistance of the glued elements, what is due to the hardening principles and penetration of the adhesive into the substrate. The gluelines of the tested systems PVAc, EPI and 1K‐PUR within the jointed wood lamellas was very vapor tight, which has to be considered for a building physical evaluation of glued wood elements.