bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baghdadi Jews in Hong Kong: converting cultural, social and economic capital among three transregional networks
Authors: PLÜSS CAROLINE 
Published: December 2010

AbstractThis article is an analysis of the attempts of Baghdadi Jewish traders in Hong Kong in the second half of the nineteenth century to construct and convert cultural, social and economic capital within and between the transregional networks of the Baghdadi diaspora, the Jewish diaspora and the British colonial elite. The analysis of the multiple and multi‐directional intersections between the cultural, social and economic characteristics of the three networks shows that Baghdadi social capital accounted for significant ruptures and disjunctures between the increasing cosmopolitanization, deterritorialization and hybridization of the Baghdadi traders' cultural identities and the definition of Baghdadi cultural capital. An understanding of the role of Baghdadi social capital in accounting for the construction and convertibility of cultural, social and economic capital among these three transregional networks helps to explain the reproduction of social inequalities under increasing conditions of globalization, that is, under conditions that potentially augmented the number of sources defining cultural capital.
Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques
Authors: De Meyer Inge , Martinet Wim , Van Hove Cor E , Schrijvers Dorien M , Hoymans Vicky Y , Van Vaeck Luc , Fransen Paul , Bult Hidde , De Meyer Guido RY 
Published: December 2010

BACKGROUND AND PURPOSE Lithium chloride (LiCl) inhibits inositol monophosphatase (IMPase) at therapeutic concentrations. Given that LiCl induces death in cultured macrophages and that macrophages play an active role in atherosclerotic plaque destabilization, we investigated whether LiCl would induce selective macrophage death to stabilize the structure of the plaque.EXPERIMENTAL APPROACH The effect of LiCl was assessed on macrophages and smooth muscle cells (SMCs) in culture, in isolated atherosclerotic carotid arteries from rabbits and after local in vivo treatment via osmotic minipumps to rabbits with collared atherosclerotic carotid arteries. In addition, in vitro experiments were performed to elucidate the mechanism of LiCl‐induced macrophage death.KEY RESULTS In vitro, whereas SMCs were highly resistant, LiCl induced macrophage death characterized by externalization of phosphatidylserine, caspase‐3 cleavage and DNA fragmentation, all indicative of apoptosis. LiCl reduced inositol‐1,4,5‐trisphosphate levels in macrophages. Moreover, the IMPase inhibitor L‐690 330 as well as IMPase gene silencing induced macrophage apoptosis. Both in vitro treatment of rabbit atherosclerotic carotid arteries with LiCl and local in vivo administration of LiCl to the plaques decreased plaque macrophages through apoptosis, as shown by terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick‐end labelling (TUNEL), without affecting SMCs. Vasomotor studies in vitro showed that LiCl did not affect the functionality of SMCs and endothelial cells.CONCLUSIONS AND IMPLICATIONS LiCl selectively decreased the macrophage load in rabbit atherosclerotic plaques via IMPase inhibition without affecting the viability or functionality of SMCs and endothelial cells. These data provide evidence for local administration of an IMPase inhibitor to stabilize atherosclerotic plaques.
Using enriched stable isotopes of barium and magnesium to batch mark otoliths of larval golden perch (Macquaria ambigua, Richardson)
Authors: Woodcock S. H. , Gillanders B. M. , Munro A. R. , McGovern F. , Crook D. A. , Sanger A. C. 
Published: December 2010

Woodcock SH, Gillanders BM, Munro AR, McGovern F, Crook DA, Sanger AC. Using enriched stable isotopes of barium and magnesium to batch mark otoliths of larval golden perch (Macquaria ambigua, Richardson). Ecology of Freshwater Fish 2011: 20: 157–165. © 2010 John Wiley & Sons A/SAbstract –  Enriched stable isotope immersion techniques were used to mark the otoliths of larval golden perch (Macquaria ambigua) immediately post‐hatch. Two experiments were undertaken: the first involved rearing larvae in water enriched with three concentrations of 137Ba for 1–5 days. Marks were produced in as little as 1 day; however, otolith isotope ratios reached equilibrium with the water in 5 days at 90 μg·l−1. The second experiment involved rearing larvae in isotope enriched water with combinations of stable isotopes of Ba and Mg for 4 days after hatching. Seven significantly different isotopic signatures were produced using three Ba isotopes, which were reflective of the water. Only slight differences were found in otoliths of larvae that were reared in combinations of Mg isotopes, which did not reflect the water chemistry. The length of golden perch at 3 weeks of age showed that isotope immersion did not negatively affect early growth.
Hepatoblastoma in a 4‐year‐old girl with Fanconi anaemia
Authors: Kopic Sascha , Eirich Katharina , Schuster Beatrice , Hanenberg Helmut , Varon‐Mateeva Raymonda , Rittinger Olaf , Schimpl Günther , Schindler Detlev , Jones Neil 
Published: December 2010

AbstractCase report:  Hepatoblastoma was diagnosed in a 4‐year‐old girl receiving growth hormone substitution therapy for short stature. Owing to multiple congenital malformations, VACTERL‐H (vertebral, anal, cardiac, tracheal, renal and limb anomalies with hydrocephalus) association had been suggested. Elevated chromosomal breakage rates and G2 phase arrest induced by DNA‐crosslinking agents in cellular assays confirmed the diagnosis of Fanconi anaemia (FA), a tumour susceptibility syndrome known to be associated with hepatocellular carcinoma following androgen therapy. Subsequent genotyping revealed biallelic mutations in the FANCD1/BRCA2 gene.Conclusion:  We describe the first case of hepatoblastoma in a patient with FA to raise awareness of this tumour type in the close clinical observation of early cancer‐prone forms of this condition, particularly in the presence of FANCD1/BRCA2 mutations. The present case also underscores the importance of FA testing in patients with VACTERL(‐H).
Post-Translational Inactivation of Endothelial Nitric Oxide Synthase in the Transgenic Sickle Cell Mouse Penis
Authors: Musicki Biljana , Champion Hunter C. , Hsu Lewis L. , Bivalacqua Trinity J. , Burnett Arthur L. 
Published: December 2010

ABSTRACT

Introduction
Sickle cell disease (SCD)-associated priapism is characterized by endothelial nitric oxide synthase (eNOS) dysfunction in the penis. However, the mechanism of decreased eNOS function/activation in the penis in association with SCD is not known.

Aims
Our hypothesis in the present study was that eNOS is functionally inactivated in the SCD penis in association with impairments in eNOS post-translational phosphorylation and the enzyme’s interactions with its regulatory proteins.

Methods
Sickle cell transgenic (sickle) mice were used as an animal model of SCD. Wild-type (WT) mice served as controls. Penes were excised at baseline for molecular studies. eNOS phosphorylation on Ser-1177 (positive regulatory site) and Thr-495 (negative regulatory site), total eNOS, and phosphorylated AKT (upstream mediator of eNOS phosphorylation on Ser-1177) expressions, and eNOS interactions with heat-shock protein 90 (HSP90) and caveolin-1 were measured by Western blot. Constitutive NOS catalytic activity was measured by conversion of L-[14C]arginine-to-L-[14C]citrulline in the presence of calcium.

Main Outcome Measures
Molecular mechanisms of eNOS dysfunction in the sickle mouse penis.

Results
eNOS phosphorylated on Ser-1177, an active portion of eNOS, was decreased in the sickle mouse penis compared with WT penis. eNOS interaction with its positive protein regulator HSP90, but not with its negative protein regulator caveolin-1, and phosphorylated AKT expression, as well as constitutive NOS activity, were also decreased in the sickle mouse penis compared with WT penis. eNOS phosphorylated on Thr-495, total eNOS, HSP90, and caveolin-1 protein expressions in the penis were not affected by SCD.

Conclusions
These findings provide a molecular basis for chronically reduced eNOS function in the penis by SCD, which involves decreased eNOS phosphorylation on Ser-1177 and decreased eNOS-HSP90 interaction.
Quality of Life and Sexual Function After Type c2/Type III Radical Hysterectomy for Locally Advanced Cervical Cancer: A Prospective Study
Authors: Plotti Francesco , Sansone Milena , Di Donato Violante , Antonelli Elena , Altavilla Tiziana , Angioli Roberto , Panici Pierluigi Benedetti 
Published: December 2010

ABSTRACT

Introduction
The introduction of screening programs have made cervical cancer detectable at earlier stages and in younger patients. Nevertheless, only a few studies have examined the QoL and sexual function in disease-free cervical cancer survivors.

Aim
The objective of this study is to evaluate the sexual function in a cervical cancer patient’s group treated with neoadjuvant chemotherapy (NACT) plus type C2/type III radical hysterectomy (RH).

Methods
We have enrolled in the oncologic group (OG) sexually active patients affected by cervical cancer (stage IB2 to IIIB) treated with NACT followed by RH.

Main Outcome Measures
Included subjects were interviewed with the European Organization for Research and Treatment of Cancer (EORTC) QLQ-CX24 Questionnaire. Two consecutive assessments were recorded: at the first evaluation postoperatively (T1) and at the 12-month follow-up visit (T2). Results were compared with a benign gynecological disease group (BG) and with a healthy control group (HG).

Results
A total of 33 patients for OG, 37 for BG, and 35 women for HG were recruited. After surgery, sexual activity has been resumed by 76% of the OG patients and 83.7% of the BG patients (P = not significant). Cancer survivors had clinically worse problems with symptom experience, body image, and sexual/vaginal functioning than controls (P &lt; 0.05). OG patients also reported more severe lymphedema, peripheral neuropathy, menopausal symptoms, and sexual worry. For sexual activity, the score difference between cancer survivors and women with benign gynecological disease is not statically significant. Concerning sexual enjoyment assessment, our study shows comparable results for OG and BG.

Conclusion
Nevertheless, the worsening of symptom experience, body image, and sexual/vaginal functioning, OG patients have same sexual activity and sexual enjoyment data compared with those of BG patients. Thus, NACT followed by RH could be a valid therapeutic strategy to treat and improve well-being especially in young cervical cancer patients.
Glycosylated Serum Protein May Improve Our Ability to Predict Endothelial and Erectile Dysfunction in Nonorganic Patients
Authors: Huang Yanping , Sun Xiangzhou , Liu Guihua , Yao Fengjuan , Zheng Fufu , Dai Yuping , Tu Xiangan , Xie Xiaoyan , Deng Liwen , Zhang Dingmei , Zhang Yadong , Bian Jun , Gao Yong , Ye Yunlin , Deng Chunhua , Zhang Yuanyuan 
Published: December 2010

ABSTRACT

Introduction
Early prediction of erectile dysfunction (ED) is critical in the treatment of impotence. Underlying pathogenesis may be the reason for ED without organic causes in young men.

Aim
We evaluated the early predictive value of glycosylated serum protein (GSP) in young patients whose ED was diagnosed as “nonorganic” in origin according to general criteria.

Methods
A total of 150 young men with ED and 27 healthy men without ED were evaluated, including International Index of Erectile Function-5 (IIEF-5), causes of ED, influential or risk factors for ED, vascular parameters, and serum biochemical markers. Fifty-two ED patients aged 20–40 years without known etiology and 22 age-matched normal subjects were enrolled. The further assessment of two groups focused on vascular endothelial function and glycometabolic state.

Main Outcome Measures
Relationships among the IIEF-5 scores, flow-mediated dilation (FMD), and GSP were analyzed in cases vs. controls, using Pearson’s correlation and multiple linear regression analysis.

Results
No significant differences in baseline characteristics, cardiovascular risks, and conventional biomarkers were found between testing and control groups, except fasting blood glucose level (4.69 ± 0.50 vs. 4.29 ± 0.48, P = 0.003). FMD values were significantly reduced in cases compared with controls and correlated positively with IIEF-5 scores (r = 0.629, P &lt; 0.001). GSP levels were significantly increased in the ED cases compared with controls and correlated negatively with IIEF-5 scores (r = −0.504, P &lt; 0.001) and FMD values (r = −0.469, P &lt; 0.001). These parameters independently predicted ED presence. The positive predictive value of FMD &gt; 11.55% for excluding ED and of GSP &gt; 210.50 mg/L for diagnosing ED were 86.4% (area under the curve [AUC]: 0.942, specificity: 88.4%) and 84.5% (AUC: 0.864, specificity: 72.7%), respectively.

Conclusions
Underlying glycometabolic disorder and subclinical endothelial dysfunction may be served as early markers for organic ED in young ED patients without well-known related risk factors. GSP level may improve our ability to predict endothelial dysfunction and erectile dysfunction.
Impact of Long-Term Gonadotropin Replacement Treatment on Sleep in Men with Idiopathic Hypogonadotropic Hypogonadism
Authors: Ismailogullari Sevda , Korkmaz Cuma , Peker Yüksel , Bayram Fahri , Karaca Züleyha , Aksu Murat 
Published: December 2010

Abstract

Introduction
Concern has been expressed in recently published literature that gonadotropin replacement therapy (GnRT) in hypogonadism may alter sleep architecture and induce, or worsen, obstructive sleep apnea (OSA).

Aim
To investigate the sleep stages and sleep-breathing parameters in young men with idiopathic hypogonadotropic hypogonadism (IHH)—a treatable form of male infertility and sexual dysfunction—before and 12 months following GnRT.

Methods
Sixteen male patients with IHH (mean age 27.5 ± 10.5 years, range 17–48 years) and 16 individually age-matched healthy men were included in the study. Human chorionic gonadotropin (HCG) was administered 1,500 U intramuscularly three times/week for 6 months, and then 75 U twice/week, recombinant follicle stimulating hormone (FSH) was added to HCG for the following 6 months. Polysomnography (PSG) recordings were performed at baseline in all and following the GnRT in the patient group.

Main Outcome Measures
Sleep stages and sleep-breathing parameters on PSG.

Results
Patients with IHH had a higher percentage of slow-wave-sleep (SWS) (22.3 ± 6.3%) compared to that in the healthy controls (14.5 ± 9.5%; P = 0.009). Four patients and one control subject had OSA (Apnea-Hypopnea Index [AHI] &gt; 5-h) at baseline (not significant). Following the GnRT in the patient group, there was a slight decrease in SWS (18.6 ± 6.4%; P = 0.05) without any significant changes regarding the sleep-breathing parameters in the whole patient group. However, of the four patients with OSA at baseline, the GnRT was associated with worsening of the AHI in three of them.

Conclusions
IHH in men is associated with a higher percentage of SWS. One-year GnRT slightly decreases SWS and does not induce OSA. However, in patients with OSA at baseline long-term GnRT should be exercised with caution.
Isolated Infection of a Decommissioned Penile Prosthesis Reservoir with Actinomyces neuii
Authors: Hsi Ryan S. , Hotaling James M. , Spencer Elysia S. , Bollyky Paul L. , Walsh Thomas J. 
Published: December 2010

ABSTRACT

Introduction
Inflatable penile prostheses (IPPs) are a well-established and reliable treatment for medication refractory erectile dysfunction. The most serious complication with IPPs is infection, with the reported incidence after primary placement 1% to 3% and after revision surgery 8% to 18%.

Aim
The aim of this report is to describe an infected decommissioned IPP reservoir with Actinomyces neuii with successful preservation of a functioning implant.

Methods
After 9 years of successful use with an IPP (AMS 700 CX) for Peyronie’s disease and organic erectile dysfunction, a 79-year-old man underwent replacement with an AMS 700 LGX. The decommissioned reservoir was kept in the right prevesical space, and the new reservoir was placed in the left prevesical space. Three months later, he presented with right inguinal pain and swelling.

Results
He was found to have an infected right reservoir with A. neuii, sparing his new IPP. After removal of the right reservoir, he had an uneventful recovery and has shown no evidence of infection in the new device.

Conclusion
Revision surgery for IPPs carries a higher risk for implant infection. This is the first report of a genitourinary implant infection with A. neuii. Aggressive surgical and medical treatment may allow preservation of the functioning implant, despite gross infection of the decommissioned reservoir.
The Diagnostic Value of the Premature Ejaculation Diagnostic Tool and its Association with Intravaginal Ejaculatory Latency Time
Authors: Kam Sung Chul , Han Deok Hyun , Lee Sung Won 
Published: December 2010

ABSTRACT

Introduction
Premature ejaculation (PE) is the most prevalent male ejaculation disorder. The premature ejaculation diagnostic tool (PEDT) was developed to systematically apply the DSM-IV-TR criteria in diagnostic PE.

Aims
To evaluate the diagnostic value of the PEDT and its association with intravaginal ejaculatory latency time (IELT).

Methods
(i) Korean validation of PEDT: data was collected from men interviewed by one of the two clinical experts, who made a diagnostic of present or absence of PE, using DSM-IV-TR criteria. A total of 103 patients with PE and 100 men without PE were enrolled into the study and requested to complete the PEDT; and (ii) The correlation between IELT and PEDT: 200 participants were enrolled and each participant was asked to make out PEDT. All participants were requested to measure IELT.

Main Outcome Measures
Validity and reliability of the PEDT and its association with IELT.

Results
The geometric mean IELT of the PE group was 115.37 ± 78.14 seconds. The number of men reporting IELTs of &lt;1, 1 to ≤2, and &gt;2 minutes were 28 (28.6%), 29 (29.6%), and 41 (41.8%), respectively. The Cronbach’s alpha score was calculated as 0.93, showing adequate internal consistency. The test–retest correlation coefficients of each item were higher than 0.72 and the correlation coefficients of the total score was 0.88. (P &lt; 0.001) Sensitivity and specificity analyses suggested a score of ≤8 indicated no PE, 9 and 10 probable PE, and ≥11 PE. The PEDT total score and IELT showed an adequate negative correlation. (ρ = −0.77, P &lt; 0.0001) also, the PEDT total score of the PE subgroup (IELT ≤ 2 minutes) and IELT showed a negative correlation. (ρ = −0.6, P &lt; 0.0001)

Conclusions
The PEDT was highly effective in detecting the presence of PE. The result of our study supports its validity as a diagnostic tool in the clinical setting.
Chronic Vardenafil Treatment Improves Erectile Function via Structural Maintenance of Penile Corpora Cavernosa in Rats with Acute Arteriogenic Erectile Dysfunction
Authors: Hotta Yuji , Hattori Mayuko , Kataoka Tomoya , Ohno Risa , Mikumo Mayumi , Maeda Yasuhiro , Kimura Kazunori 
Published: December 2010

ABSTRACT

Introduction
Chronic phosphodiesterase type 5 inhibitor treatment may be useful in reversing erectile dysfunction (ED). However, the mechanisms of this improvement remain unknown.

Aim
The aim of this article was to determine the mechanisms of the improvement by chronic vardenafil treatment for acute arteriogenic ED in rats.

Methods
Eight-week-old male Wistar-ST rats were divided into four groups: sham-operated rats (Control group) and rats with acute arteriogenic ED induced by ligating bilateral internal iliac arteries (Ligation group), subsequently treated with low-dose (0.4 mg/kg/day; VL group) or high-dose (4.0 mg/kg/day; VH group) vardenafil for 20 days from 1 week after ligature.

Main Outcome Measures
Erectile function was assessed based on changes of intracavernous pressure (ICP) followed by electrostimulation of the cavernous nerves and was evaluated by the area under the curve of ICP/area under the curve of mean arterial pressure (area of ICP/MAP). Transforming growth factor (TGF)-β1, vascular endothelial growth factor-A, endothelial nitric oxide synthase (eNOS), inducible NOS, and neuronal NOS mRNA expression levels in penile corpus cavernosum were determined by real-time PCR. Western blotting for TGF-β1 protein levels and Masson trichrome staining of penile tissues were performed in each at group 4 weeks after surgery.

Results
In the VH group, area of ICP/MAP was significantly improved when compared with the Ligation group (P &lt; 0.01). The smooth muscle (SM)/collagen ratio in the VH group was significantly higher than in the Ligation group (P &lt; 0.05), and was comparable with that in the Control group. TGF-β1 mRNA and protein levels in the VH group were significantly lower when compared with the Ligation group (P &lt; 0.05).

Conclusions
Chronic vardenafil administration ameliorates impairment of penile hemodynamics and maintains normal SM to collagen ratio in cavernous tissues after acute arterial injury in rats.
ANTIOXIDANT AND ANTIMICROBIAL EFFECTIVENESS OF CATECHIN‐IMPREGNATED PVA–STARCH FILM ON RED MEAT
Authors: WU JIH‐GUAN , WANG PEI‐JIN , CHEN SHAUN C. 
Published: December 2010

ABSTRACT A biodegradable polyvinyl alcohol (PVA)–starch film was fabricated for use as a packaging film with added antioxidant and antimicrobial properties. PVA–starch films were impregnated with catechins extracted from green tea. The catechins were identified and quantified by HPLC, and the antioxidant and antimicrobial characteristics of the packaging film were examined using thiobarbituric acid‐reactive substance values and cell count methods. The results showed that tensile strength and elongation decreased with increasing amounts of incorporated constituents. In a model study, the inclusion of catechins at a level of 1,000 ppm inhibited the growth of airborne microorganisms, and antioxidant capacity in cooking oil was clearly reached when 500 ppm catechins were incorporated into the film. In a feasibility test, a level of 1,000 ppm was found to be sufficient for effective antioxidant and antimicrobial activities of raw beef at refrigeration temperatures. The results suggest that a PVA–starch film with catechins incorporated may be beneficial for maintaining food quality through its antioxidant and antimicrobial activities. PRACTICAL APPLICATIONSCertain phytochemicals have both antioxidant and antimicrobial activities, and could be incorporated into packaging films for quality retention. Therefore, the use of catechin into a biodegradable film composed of polyvinyl alcohol and starch should be beneficial to assure quality and to be environment friendly. The active film developed in this study can be used as a home‐use wrap for fresh meat products, such as red meat, poultry or seafood, as these products are very susceptible to oxidation and microbial growth.