bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid-Derived Suppressor Cells Prevent Type 1 Diabetes in Murine Models
Authors: Yin Bingjiao , Ma Ge , Yen Chun-Yu , Zhou Zuping , Wang George X. , Divino Celia M. , Casares Sofia , Chen Shu-Hsia , Yang Wen-Chin , Pan Ping-Ying 
Published: October 2010

Abstract
Effective immunotherapy for type 1 diabetes (T1D) relies on active induction of peripheral tolerance. Myeloid-derived suppressor cells (MDSCs) play a critical role in suppressing immune responses in various pathologic settings via multiple mechanisms, including expansion of regulatory T cells (Tregs). In this study, we investigated whether MDSCs could act as APCs to induce expansion of Ag-specific Tregs, suppress T cell proliferation, and prevent autoimmune T1D development. We found that MDSC-mediated expansion of Tregs and T cell suppression required MHC-dependent Ag presentation. A murine T1D model was established in INS-HA/RAG−/− mice in which animals received CD4-HA-TCR transgenic T cells via adoptive transfer. We found a significant reduction in the incidence of diabetes in recipients receiving MDSC plus HA, but not OVA peptide, leading to 75% diabetes-free mice among the treated animals. To test further whether MDSCs could prevent diabetes onset in NOD mice, nondiabetic NOD/SCID mice were injected with inflammatory T cells from diabetic NOD mice. MDSCs significantly prevented diabetes onset, and 60% of MDSC-treated mice remained diabetes free. The pancreata of treated mice showed significantly lower levels of lymphocyte infiltration in islet and less insulitis compared with that of the control groups. The protective effects of MDSCs might be mediated by inducing anergy in autoreactive T cells and the development of CD4+CD25+Foxp3+ Tregs. Thist study demonstrates a remarkable capacity of transferred MDSCs to downregulate Ag-specific autoimmune responses and prevent diabetes onset, suggesting that MDSCs possess great potential as a novel cell-based tolerogenic therapy in the control of T1D and other autoimmune diseases.
Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis
Authors: Tonel Giulia , Conrad Curdin , Laggner Ute , Di Meglio Paola , Grys Katarzyna , McClanahan Terrill K. , Blumenschein Wendy M. , Qin Jian-Zhong , Xin Hong , Oldham Elizabeth , Kastelein Robert , Nickoloff Brian J. , Nestle Frank O. 
Published: October 2010

Abstract
Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23–dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders.
Store-Operated Ca2+ Entry through ORAI1 Is Critical for T Cell-Mediated Autoimmunity and Allograft Rejection
Authors: McCarl Christie-Ann , Khalil Sara , Ma Jian , Oh-hora Masatsugu , Yamashita Megumi , Roether Jens , Kawasaki Takumi , Jairaman Amit , Sasaki Yoshiteru , Prakriya Murali , Feske Stefan 
Published: October 2010

Abstract
ORAI1 is the pore-forming subunit of the Ca2+ release-activated Ca2+ (CRAC) channel, which is responsible for store-operated Ca2+ entry in lymphocytes. A role for ORAI1 in T cell function in vivo has been inferred from in vitro studies of T cells from human immunodeficient patients with mutations in ORAI1 and Orai1−/− mice, but a detailed analysis of T cell-mediated immune responses in vivo in mice lacking functional ORAI1 has been missing. We therefore generated Orai1 knock-in mice (Orai1KI/KI) expressing a nonfunctional ORAI1-R93W protein. Homozygosity for the equivalent ORAI1-R91W mutation abolishes CRAC channel function in human T cells resulting in severe immunodeficiency. Homozygous Orai1KI/KI mice die neonatally, but Orai1KI/KI fetal liver chimeric mice are viable and show normal lymphocyte development. T and B cells from Orai1KI/KI mice display severely impaired store-operated Ca2+ entry and CRAC channel function resulting in a strongly reduced expression of several key cytokines including IL-2, IL-4, IL-17, IFN-γ, and TNF-α in CD4+ and CD8+ T cells. Cell-mediated immune responses in vivo that depend on Th1, Th2, and Th17 cell function were severely attenuated in ORAI1-deficient mice. Orai1KI/KI mice lacked detectable contact hypersensitivity responses and tolerated skin allografts significantly longer than wild-type mice. In addition, T cells from Orai1KI/KI mice failed to induce colitis in an adoptive transfer model of inflammatory bowel disease. These findings reaffirm the critical role of ORAI1 for T cell function and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Domain V Peptides Inhibit β2-Glycoprotein I-Mediated Mesenteric Ischemia/Reperfusion-Induced Tissue Damage and Inflammation
Authors: Fleming Sherry D. , Pope Michael R. , Hoffman Sara M. , Moses Tiffany , Bukovnik Urska , Tomich John M. , Wagner Lynn M. , Woods Keith M. 
Published: October 2010

AbstractReperfusion of ischemic tissue induces significant tissue damage in multiple conditions, including myocardial infarctions, stroke, and transplantation. Although not as common, the mortality rate of mesenteric ischemia/reperfusion (IR) remains &gt;70%. Although complement and naturally occurring Abs are known to mediate significant damage during IR, the target Ags are intracellular molecules. We investigated the role of the serum protein, β2-glycoprotein I as an initiating Ag for Ab recognition and β2-glycoprotein I (β2-GPI) peptides as a therapeutic for mesenteric IR. The time course of β2-GPI binding to the tissue indicated binding and complement activation within 15 min postreperfusion. Treatment of wild-type mice with peptides corresponding to the lipid binding domain V of β2-GPI blocked intestinal injury and inflammation, including cellular influx and cytokine and eicosanoid production. The optimal therapeutic peptide (peptide 296) contained the lysine-rich region of domain V. In addition, damage and most inflammation were also blocked by peptide 305, which overlaps with peptide 296 but does not contain the lysine-rich, phospholipid-binding region. Importantly, peptide 296 retained efficacy after replacement of cysteine residues with serine. In addition, infusion of wild-type serum containing reduced levels of anti–β2-GPI Abs into Rag-1−/− mice prevented IR-induced intestinal damage and inflammation. Taken together, these data suggest that the serum protein β2-GPI initiates the IR-induced intestinal damage and inflammatory response and as such is a critical therapeutic target for IR-induced damage and inflammation.
Commentary on "Expansions for Eigenfunctions and Eigenvalues of large-$n$ Toeplitz Matrices"
Authors: Ehrhardt Torsten 
Published: October 2010

A Commentary on the paper by L. P. Kadanoff [Pap. Phys. 2, 020003 (2010)].Received: 29 September 2010, Accepted: 4 October 2010; Edited by: A. G. Green; DOI: 10.4279/PIP.020004
Prognostic Factors and Therapeutic Strategies of Thyroid Carcinomas Originating from Follicular Cells
Authors: Miyauchi Akira , Ito Yasuhiro 
Published: October 2010

AbstractThere are three types of thyroid carcinoma originating from follicular cells, papillary carcinoma (PTC), follicular carcinoma (FTC) and anaplastic carcinoma (ATC). PTC and FTC have generally indolent nature but ATC, which is believed to arise from PTC and FTC, are very progressive and display a dire prognosis. PTC and FTC are called differentiated carcinoma and regarded as a single group, but biological characteristics of these two types of carcinoma significantly differ. PTC frequently metastasizes to the regional lymph nodes and FTC generally metastasizes to distant organs such as the lung and bone. Most PTC can be diagnosed on preoperative imaging studies and fine needle aspiration biopsy (FNAB) and can be treated as malignancy. However, it is difficult to diagnose FTC preoperatively and most FTC are diagnosed on postoperative pathological examination. In this review, we describe prognostic factors of PTC and FTC and their therapeutic strategies. Furthermore, recent advances of treatment for ATC are also described.
Usefulness of Positron Emission Tomography for Characterization of the Indeterminate Adrenal Tumor
Authors: Elaraj Dina M , Sturgeon Cord 
Published: October 2010

Abstract
Incidental adrenal masses are common, with most representing benign, nonfunctional cortical adenomas. The diagnostic approach should consist of a biochemical evaluation for hormonal hypersecretion, as well as an assessment of the risk of malignancy (primary adrenal cancer vs metastasis from another site). The size and appearance of the adrenal tumor on imaging studies are critical to management decisions. Computed tomography (CT) or T1 weighted chemical shift magnetic resonance imaging (MRI) can usually diagnose a cortical adenoma based on characteristics related to intracellular lipid content. However, 30% of cortical adenomas are lipid-poor, and will be classified as indeterminate on CT or MRI. Fluorodeoxyglucose-positron emission tomography (FDG-PET) is a useful method of further characterizing an indeterminate adrenal mass, particularly in an oncology patient in whom identification of an adrenal metastasis will affect disease stage and therapy. FDG-PET has been found to have a sensitivity of 93 to 100% and a specificity of 70 to 100% for the identification of an adrenal malignancy in both oncology and non-oncology patient populations. Indications for adrenalectomy include all functional adrenal tumors, known or suspected primary adrenal cancers that appear resectable, adrenal tumors > 4 cm, and isolated adrenal metastases.
Tattooing as Alternative Therapy for Goiter
Authors: Chand Gyan , Reddy Sagili Vijaya Bhaskar , Bharani Tanmay , Singh Deependra 
Published: October 2010

Abstract
Goitre is an ancient art form being practiced world over for various reasons. We report a case where tattoo marking was used as a form of therapy for goitre. Tattoo therapy had failed to provide any benefit to the patient who later underwent total thyroidectomy with good post operative recovery
Endoscopic Dacryocystorhinostomy without Probing: Surgical Outcome
Authors: LNU Rijuneeta , Gupta Ashok K 
Published: October 2010

AbstractNinety-eight cases of nasolacrimal duct obstruction including 6 bilateral cases were included in the study done at Postgraduate Institute of Medical Research, Chandigarh. All the cases had been divided into three groups with Group I including cases in which 12 endoscopic dacryocystorhinostomy (DCR) with dilatation and probing and stent insertion were performed. In Group II, 23 Endo DCR performed with intraoperative dilatation and probing but no stent insertion. Group III included 69 cases of Endo DCR without dilatation and probing and no stent insertion. Overall success rate was found to be 94.3% with Group III cases having a success rate of 97.1% and was found statistically significant on comparing with that of Group II (p value: 0.03).
Four Cases of Ossifying Fibromas: A Rural Medical College Hospital Experience
Authors: Naik Sudhir 
Published: October 2010

ABSTRACT

Background
Ossifying fibroma is an uncommon tumor of the craniofacial skeleton presenting in several variant histopathological subtypes. Ossifying fibroma is a benign fibro-osseous lesion that commonly involves the maxilla.1 Ossifying fibromas occur predominantly in women, frequently during the 3rd and 4th decades of life.1 The overlapping clinical and histopathological features of these subtypes have led to diagnostic dilemma and confusion.1 Complete excision of this tumor has become a necessity since it is notorious for recurrence.1

Aims
To study and compare the clinical profiles of various types of ossifying fibroma and also the surgical approaches to the tumor. To discuss the diagnostic difficulties and controversies associated with the tumor.

Setting
Medical college referral hospital.

Design
Case reports of 4 patients presenting to our medical college OPD.

Methods
Planned surgical excision based on criteria.

Results
Four cases of different types of ossifying fibroma were successfully treated by various surgical approaches. 42 papers related to diagnostic and treatment aspects of ossifying fibroma were studied.

Conclusion
The diagnostic dilemma of ossifying fibroma can be overcome with a combination of clinical, radiological and pathological criteria. Complete surgical excision of the tumor is possible when surgery is based on preplanned criteria. Combination of 2 or more surgical approaches may be necessary in many cases in order to ensure complete clearance and prevent recurrence of the tumor.
Sino-orbital Lymphoma: Case Report and Review of Literature
Authors: Joshi Kusum , Kumar Narinder 
Published: October 2010

Abstract
The orbit is involved in 10% of all lymphomas. Paranasal sinuses and nose are other sites for extranodal lymphoma that are involved in upto 2.6 to 6.7% of lymphomas involving head and neck region and are second most common presentation of extranodal lymphoma. In nearly 22.5% of patients, sinonasal lymphoma and orbital lymphoma may coexist. The present report describes such patient with first presentation to an ophthalmologist with an attempt to review the present literature of coexistent orbital and paranasal sinuses lymphoma.
Capillary Hemangioma of the Maxillary Sinus: A Case Report and Review of Literature
Authors: Mohan Harsh , Singh Charanjit 
Published: October 2010

Abstract
Capillary hemangioma of the maxillary sinus is a rare entity. It commonly presents as a sinonasal mass with nasal obstruction, intermittent epistaxis and occasionally as a cheek swelling. Computed tomography and angiography assist in making a correct diagnosis. Biopsy is not usually recommended as it can cause profuse bleeding and may yield false results. Selective arterial embolization followed by surgical resection forms the mainstay of treatment.
Endoscopic Dacryocystorhinostomy: Our Experience
Authors: Suligavi Shashidhar S , Chougule SS , Doddamani SS , Hiremath CS 
Published: October 2010

Abstract
Endoscopic dacryocystorhinostomy is an established surgery for nasolacrimal duct block. We did a prospective study to evaluate the results and advantages. All the 90 patients underwent endoscopic DCR and 26 patients had septoplasty simultaneously. Postoperative evaluation of patency and relief of symptoms was done up to 6th month. Our study concludes that endoscopic. DCR is a safe, simple procedure with a better success rate and fewer complications along with review of literature.
Nasal Septal Abscess: A Retrospective Study of 20 Cases in KVG Medical College and Hospital, Sullia
Authors: Naik Sudhir , Naik Sudhir M 
Published: October 2010

ABSTRACT

Objective
Twenty patients who presented to the ENT, head and neck department with nasal septal abscess were retrospectively studied.

Design
Retrospective study.

Setting
KVG Medical College and Hospital, Sullia.

Study period
January 2006 to June 2010 (54 months)

Patients
Twenty patients (17 males and 3 females), aged between 7 to 45 years (average age 25.25 years), with nasal septal abscess were studied.

Intervention
All patients were admitted and posted for emergency incision and drainage under antibiotic cover. In 13 cases the destroyed septal cartilage was repaired with autologous conchal cartilage in the same sitting of incision and drainage. In two cases the same procedure was done in two different sittings.

Results
Sixteen patients were implanted autologous conchal cartilage at time of incision and drainage and most of them doing well at 6 months of follow-up.

Conclusion
Nasal septal abscess promptly treated under antibiotic cover total reconstruction of abscess-induced destruction of nasal septal cartilage with patients own conchal cartilage grafts so far, resulted in normal dorsum of the nose being retained during follow-up.
Bacteriological Study of Chronic Maxillary Sinusitis with Special Reference to Anaerobes
Authors: Suligavi Shashidhar S , Gokale Shilpa K 
Published: October 2010

AbstractAspirates from 50 chronically inflamed maxillary sinuses were processed for aerobic and anaerobic bacteria. Bacterial growth was present in 48 (96%) specimens. There were 110 bacterial isolates (2.2/specimen). Forty of the isolates were aerobic or facultative organisms (0.8/ specimen). The predominant aerobic or facultative organisms were Staphylococcus aureus, coagulase-negative staphylococcus (CNS),S. pneumoniae, E. coli, H. influenzae and P. aeruginosa. Seventy anaerobes were isolated (1.4/specimen), Prevotella spp, Peptostreptococcus spp., Porphyromonas spp. and bacteroides spp. being predominant. These findings illustrate the presence of polymicrobial aerobic-anaerobic flora in patients with chronic maxillary sinusitis.
Rhino-orbital Aspergillosis: Changing Trends in the Management?
Authors: Gupta Anuragini , Chopra Aditi , Raj Anoop 
Published: October 2010

Abstract

Purpose
To analyze the results of oral voriconazole following optimum management protocol for invasive sino-orbital aspergillosis.

Methods
It was a prospective study wherein all immunocompetent cases with a final histopathological diagnosis of invasive sino-orbital aspergillosis were included from a period between Jan 2007 till Dec 2009. All cases were evaluated clinically and radiologically for the condition and were classified into four groups on clinical and radiological basis. All cases were subjected to endonasal endoscopic biopsy and were subjected as per the optimum management protocol. These were then followed up for a period ranging from 6 months to 3 years clinically, endoscopically and radiologically.

Results
There were 15 cases enrolled for the study. There were 10 males and 5 females with age ranging from 14 to 43 years. The most common sign was proptosis. The cases in each group were subjected to the treatment protocol decided for the group. Residual disease was seen in 2 cases (13.34%) and recurrence was seen in 1 case (6.67%). One patient (6.67%) died of disease in our series.

Conclusion
Invasive sino-orbital aspergillosis is associated with significant morbidity and mortality. In our study, voriconazole was found to drastically improve the outcome of sino-orbital aspergillosis.
Treatment of Primary Scleral Maltoma: A Technical Challenge for Radiation Oncologist
Authors: Khosla Divya , Vasishta Rakesh Kumar , Sharma Suresh C 
Published: October 2010

Abstract
We present a case of 53 years old male who developed reddish thickening on sclera and was diagnosed as scleral maltoma after investigations. Primary scleral involvement remains only a theoretical possibility and has never been documented in literature except for one odd case report where orbital lymphoma was misdiagnosed as scleritis but later proved to be of conjunctival origin by histology.1 This case report has been brought up to highlight the technical challenges faced in planning and execution of external radiation therapy in primary scleral lymphoma.
Extranasopharyngeal Angiofibroma from the Nasal Septum: A Case Report and a Minireview
Authors: Singh PP , Gupta Neelima , Vaid Lakshmi , Chugh Neeru 
Published: October 2010

AbstractExtranasopharyngeal angiofibromas are rare tumors with only 65 cases being reported in the world literature. The most common sites involved are maxillary sinus, ethmoid sinus, sphenoid sinus, nasal septum, middle turbinate, inferior turbinate, cheek, conjunctiva, pterygomaxillary fissure, infratemporal fossa and laryngotracheal tree. We report on a case of 18 years old male patient of extranasopharyngeal angiofibroma of nasal septum.
Giant Cell Reparative Granuloma (Central) of Maxilla: Case Report and Review
Authors: Bist SS , Varshney Saurabh , Bhavna Kranti 
Published: October 2010

AbstractTerm Giant Cell Reparative Granuloma (GCRG) a non-neoplastic lesion characterized by a proliferation of granulation tissue containing numerous multinucleated giant cells was introduced by Jaffe in 1953 to describe an apparently reactive intraosseous lesion of the mandible and maxilla following trauma induced intraosseous hemorrhage. It is a disease of the young presenting as a painless swelling in the anterior jaw. It appears on radiology as a unilocular or multilocular radiolucency with a characteristic tendency of resorbing the root tips of adjacent unerupted teeth. A central giant cell granuloma of the maxilla is presented, which was diagnosed in a seventeen-year-old male and surgically treated.
A Comparison of Ukrainian Hospital Services and Functions Before and During the Russia-Ukraine War
Authors: Haque Ubydul , Bukhari Moeen Hamid , Fiedler Nancy , Wang Shanshan , Korzh Oleksii , Espinoza Juan , Ahmad Miraj , Holovanova Irina , Chumachenko Tetyana , Marchak Olga , Chumachenko Dmytro , Ulvi Osman , Sikder Ifthekar , Hubenko Hanna , Barrett Emily S. 
Published: May 2024

ImportanceSince the full-scale Russian invasion, hospitals in Ukraine have been compelled to close or operate at reduced capacity due to inadequate supplies, damage, or destruction caused by war.ObjectiveTo analyze hospital services in Ukraine during the period before and after the Russian invasion.Design, Setting, and ParticipantsOf the 450 hospitals currently functioning in Ukraine, a cross-sectional survey was carried out with the participation of 74 hospitals from 12 oblasts. Hospital administrators responded to an online survey with questions on the use of hospital services. Data were abstracted from hospital databases for the prewar period (before February 23, 2022) and during the war (February 23, 2022, to May 30, 2023).Main Outcomes and MeasuresHospital services (including emergency services, preventive services, screenings, laboratory tests, obstetrics, telehealth, pharmacy, and rehabilitation services) were compared during the prewar and war periods.ResultsOf 450 Ukrainian hospitals in operation, 74 hospitals (16.0%) across 12 oblasts provided data for the current analyses. During the war, daily emergency admissions increased to 2830, compared with 2773 before the war. At the same time, hospitals reported reduced laboratory testing (72 [97%] vs 63 [85%]), tobacco education (52 [70%] vs 36 [49%]), cancer screening (49 [66%] vs 37 [50%]), gynecological services (43 [58%] vs 32 [43%]), rehabilitation services (37 [50%] vs 27 [36%]), pharmacy services (36 [49%] vs 27 [36%]), and telehealth programs (33 [45%] vs 21 [28%]). Hospitals reported additional difficulties during the war, including disruptions in the supply chain for essential equipment and pharmaceuticals, shortages of laboratory test kits, delays in the delivery of crucial medications, and problems around appropriate medication storage due to power outages.Conclusions and RelevanceThe ongoing war has inflicted profound devastation on Ukraine’s hospitals. The findings of this cross-sectional survey offer valuable insights into the formidable challenges that hospitals confront in war-affected regions and underscore the pressing necessity for bolstering support to sustain and enhance hospital services during wartime.