bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonpersistent Nanoarchitectures Enhance Concurrent Chemoradiotherapy in an Immunocompetent Orthotopic Model of HPV+ Head/Neck Carcinoma
Authors: Gonnelli Alessandra , Gerbé de Thoré Marine , Ermini Maria Laura , Frusca Valentina , Zamborlin Agata , Signolle Nicolas , Bawa Olivia , Clémenson Céline , Meziani Lydia , Bergeron Paul , El‐Azrak Ismail , Sarogni Patrizia , Mugnaioli Enrico , Giannini Noemi , Drava Giuliana , Deutsch Eric , Paiar Fabiola , Mondini Michele , Voliani Valerio 
Published: May 2024

AbstractCisplatin chemoradiotherapy (CRT) is the established standard of care for managing locally advanced human papillomavirus‐positive head/neck carcinoma. The typically young patients may suffer serious and long‐time side effects caused by the treatment, such as dysphagia, and hearing loss. Thus, ensuring a satisfactory post‐treatment quality of life is paramount. One potential replacing approach to the classical CRT involves the combination of standard‐dose radiotherapy and radiosensitizers such as noble metal nanoparticles (NPs). However, several concerns about size, shape, and biocompatibility limit the translation of metal nanomaterials to the clinical practice. Here, it is demonstrated that a new model of nonpersistent gold nanoarchitectures containing cisplatin (NAs‐Cluster‐CisPt) generates, in combination with radiotherapy, a significant in vivo tumor‐reducing effect compared to the standard CRT, achieving a complete tumor clearance in 25% of the immunocompetent models that persist for 60 days. These findings, together with the negligible amount of metals recognized in the excretory organs, highlight that the concurrent administration of NAs‐Cluster‐CisPt and radiotherapy has the potential to overcome some clinical limitations associated to NP‐based approaches while enhancing the treatment outcome with respect to standard CRT. Overall, despite further mechanistic investigations being essential, these data support the exploiting of nonpersistent metal‐nanomaterial‐mediated approaches for oral cancer management.
Revealing the Nature of Binary‐Phase on Structural Stability of Sodium Layered Oxide Cathodes
Authors: Liu Renbin , Huang Weiyuan , Liu Jie , Li Yuhao , Wang Jing , Liu Qingshan , Ma Lu , Kwon Gihan , Ehrlich Steven N. , Wu Yangyang , Liu Tongchao , Amine Khalil , Li Hongsen 
Published: May 2024

AbstractThe emergence of layered sodium transition metal oxides featuring a multiphase structure presents a promising approach for cathode materials in sodium‐ion batteries, showcasing notably improved energy storage capacity. However, the advancement of cathodes with multiphase structures faces obstacles due to the limited understanding of the integrated structural effects. Herein, the integrated structural effects by an in‐depth structure‐chemistry analysis in the developed layered cathode system NaxCu0.1Co0.1Ni0.25Mn0.4Ti0.15O2 with purposely designed P2/O3 phase integration, are comprehended. The results affirm that integrated phase ratio plays a pivotal role in electrochemical/structural stability, particularly at high voltage and with the incorporation of anionic redox. In contrast to previous reports advocating solely for the enhanced electrochemical performance in biphasic structures, it is demonstrated that an inappropriate composite structure is more destructive than a single‐phase design. The in situ X‐ray diffraction results, coupled with density functional theory computations further confirm that the biphasic structure with P2:O3 = 4:6 shows suppressed irreversible phase transition at high desodiated states and thus exhibits optimized electrochemical performance. These fundamental discoveries provide clues to the design of high‐performance layered oxide cathodes for next‐generation SIBs.
Thermal Annealing Impact on the Sensitivity of Piezomagnetic Surface Acoustic Waveguide to Applied Magnetic Field
Authors: Marbouh Othmane , Mazzamurro Aurélien , Matar Olivier Bou , Maurice Vincent , Boutghatin Mohamed , Dusch Yannick , Addad Ahmed , Viard Romain , Pernod Phillipe , Sbiaa Rachid , Tounzi Abdelmounaim , Benabou Abdelkader , Tiercelin Nicolas , Talbi Abdelkrim 
Published: May 2024

AbstractMagnetostrictive thin films, exhibit significant utility as functionalization materials for Surface acoustic wave sensors designed for magnetic field measurements. This research investigates the influence of annealing under vacuum and magnetic field at various temperatures on the magnetic properties of the FeCo/TbCo2 thin film and therefore on the sensitivity of shear and Rayleigh acoustic waveguides functionalized with these magnetic layers. The observed effects include a reduction in magnetic anisotropy field and an increase in magnetostriction. XPS and TEM coupled with EDS microanalysis provide insights into the variations in the properties of the nanostructured magnetic film. To safeguard the magnetic film, a thin layer of SiO2 is deposited on top, serving as a protective shield. The inclusion of this layer amplifies sensitivity to applied magnetic fields for modes with shear polarization while reducing sensitivity for Rayleigh mode. In ST‐cut Quartz, the shear waves become waveguided upon the incorporation of magnetic thin films, with further enhancement achieved by introducing a SiO2 layer. Rayleigh waves are evanescent modes, the penetration depth is in the order of wavelength, and the addition of SiO2 decrease the wave confinement and therefore the sensitivity. The findings are supported by a theoretical model and experimentally validated results.
C(sp3)−H Functionalization Using Chlorine Radicals
Authors: Sadeghi Masoud 
Published: May 2024

AbstractConverting any desired C−H bond to the intended C−Z bond in a given organic molecule could be the final peak of the C−H functionalization methodology. Among the three types of C−H bonds, the functionalization of the ubiquitous C(sp3)−H bond has gained particular attention, especially in the last two decades. There are different ways to transform C(sp3)−H bonds into desired C−Z bonds. The use of chlorine radicals is one of these methods with a promising future. The literature review shows that different sources have been used for chlorine, including chloride ions (HCl or chloride salts), coordinated chlorides (transition metal complexes), and organic chlorides (organochlorine compounds). However, HCl and FeCl3 have gained the most attention among these sources. There are three major ways to convert chlorine from these sources to chlorine radicals: 1) oxidation of hydrogen chloride or chloride salts, 2) photolysis of metal chloride, and 3) transition metal insertion into C−Cl bonds. This review summarizes published research papers on the use of chlorine radicals for C(sp3)−H bonds functionalization. Therefore, chlorination reactions of C(sp3)−H bonds and reactions in which chlorine radicals do not play a direct role in C(sp3)−H bond cleavage are not within the scope of this review.
A General Strategy for Food Traceability and Authentication Based on Assembly‐Tunable Fluorescence Sensor Arrays
Authors: Cheng He , Liu Tianyue , Tian Jingsheng , An Ruixuan , Shen Yao , Liu Mingxi , Yao Zhiyi 
Published: May 2024

AbstractFood traceability and authentication systems play an important role in ensuring food quality and safety. Current techniques mainly rely on direct measurement by instrumental analysis, which is usually designed for one or a group of specific foods, not available for various food categories. To develop a general strategy for food identification and discrimination, a novel method based on fluorescence sensor arrays is proposed, composed of supramolecular assemblies regulated by non‐covalent interactions as an information conversion system. The stimuli‐responsiveness and tunability of supramolecular assemblies provided an excellent platform for interacting with various molecules in different foods. In this work, five sensor arrays constructed by supramolecular assemblies composed of pyrene derivatives and perylene derivatives are designed and prepared. Assembly behavior and sensing mechanisms are investigated systematically by spectroscopy techniques. The traceability and authentication effects on several kinds of food from different origins or grades are evaluated and verified by linear discriminant analysis (LDA). It is confirmed that the cross‐reactive signals from different sensor units encompassing all molecular interactions can generate a unique fingerprint pattern for each food and can be used for traceability and authentication toward universal food categories with 100% accuracy.
Potassium and harvest time interaction effect on alfalfa production and profitability
Authors: Baidoo Michael M. , Islam M. Anowarul 
Published: May 2024

AbstractResearchers have extensively studied and documented the effects of potassium (K) fertility on alfalfa (Medicago sativa L.). Yet, additional research is needed to determine how interactions of K, cultivar, and harvest management influence the K needs of alfalfa. To explore these interactions, we conducted 5 years of field research at the University of Wyoming James C. Hageman Sustainable Agriculture Research and Extension Center in Lingle, WY. Treatments were (a) four K rates (0, 56, 112, and 168 kg K2O ha−1 year−1) applied before planting in the fall of 2016 and after the final harvest in the fall of 2017–2020, (b) two cultivars (Hi‐Gest 360 and AFX 457), and (c) two harvest times (early harvest, late bud to early [10%] bloom, and late harvest, 7 days after early harvest), arranged in a 4 × 2 × 2 factorial under random complete blocks with four replications. At 168 kg K2O ha−1 year−1 and early harvest, a consistently significant (p < 0.05) higher yield response was observed. The same response was seen at 112 kg K2O ha−1 year−1 and late harvest. This occurred at a site with moderate‐to‐high soil K levels throughout the study period. There was a linear (p < 0.001, R2 = 0.66) and quadratic (p = 0.006, R2 = 0.61) response of forage accumulation to K rate at early and late harvest, respectively. Similar trends were also seen for stem count, relative water content, root uptake of K, and tissue K. Time of harvest showed immense potential for optimizing K's effect for a consistent high‐yield response. However, fertilizing alfalfa with 112 kg K2O ha−1 year−1 gave the most profitable production under both harvest times. If K fertilizer prices drop over time, high profits could be attained with higher K fertilization rates. After 3 years of production, average forage accumulation increased under an early harvest system and decreased under a late harvest system. Growers in Wyoming and similar regions are encouraged to consider fertilizing alfalfa with moderate K rates (∼112 kg K2O ha−1 year−1) on soils testing moderate‐to‐high in soil test K, implement a late harvest system for the first 3 years after planting, and transition to an early harvest system after the initial 3 years to maximize alfalfa profits.
Linker aggregation engineering of TADF materials to tune carrier balance for highly efficient organic LEDs with long operational lifetime
Authors: Zhang Zhen , Xia Rongrong , Wang Ke , Wu Youjun , Zang Panpan , Gan Xuemin , Liao Zhangcheng , Wei Bin , Wu Peng , Bräse Stefan , Wang Zixing 
Published: May 2024

AbstractThermally activated delayed fluorescence (TADF) molecules are regarded as promising materials for realizing high‐performance organic light‐emitting diodes (OLEDs). The connecting groups between donor (D) and acceptor (A) units in D–A type TADF molecules could affect the charge transfer and luminescence performance of TADF materials in aggregated states. In this work, we design and synthesize four TADF molecules using planar and twisted linkers to connect the aza‐azulene donor (D) and triazine acceptor (A). Compared with planar linkers, the twisted ones (Az‐NP‐T and Az‐NN‐T) can enhance A–A aggregation interaction between adjacent molecules to balance hole and electron density. As a result, highly efficient and stable deep‐red top‐emission OLEDs with a high electroluminescence efficiency of 57.3% and an impressive long operational lifetime (LT95 ∼ 30,000 h, initial luminance of 1000  cd  m−2) are obtained. This study provides a new strategy for designing more efficient and stable electroluminescent devices through linker aggregation engineering in donor–acceptor molecules.
Variations in water economy traits in two Sphagnum species across their distribution boundaries
Authors: Campbell Charles , Granath Gustaf , Rydin Håkan 
Published: May 2024

AbstractPremiseWe assessed changes in traits associated with water economy across climatic gradients in the ecologically similar peat mosses Sphagnum cuspidatum and Sphagnum lindbergii. These species have parapatric distributions in Europe and have similar niches in bogs. Sphagnum species of bogs are closely related, with a large degree of microhabitat niche overlap between many species that can be functionally very similar. Despite this, ecologically similar species do have different distributional ranges along climatic gradients that partly overlap. These gradients may favor particular Sphagnum traits, especially in relation to water economy, which can be hypothesized to drive species divergence by character displacement.MethodsWe investigated traits relevant for water economy of two parapatric bryophytes (Sphagnum cuspidatum and S. lindbergii) across the border of their distributional limits. We included both shoot traits and canopy traits, i.e., collective traits of the moss surface, quantified by photogrammetry.ResultsThe two species are ecologically similar and occur at similar positions along the hydrological gradient in bogs. The biggest differences between the species were expressed in the variations of their canopy surfaces, particularly surface roughness and in the responses of important traits such as capitulum mass to climate. We did not find support for character displacement, because traits were not more dissimilar in sympatric than in allopatric populations.ConclusionsOur results suggest that parapatry within Sphagnum can be understood from just a few climatic variables and that climatic factors are stronger drivers than competition behind trait variation within these species of Sphagnum.
Long‐term clinical observation of patients with heterozygous KIF1A variants
Authors: Kawashima Aritomo , Kodama Kaori , Okubo Yukimune , Endo Wakaba , Inui Takehiko , Ikeda Miki , Katata Yu , Togashi Noriko , Ohba Chihiro , Imagawa Eri , Iwama Kazuhiro , Mizuguchi Takeshi , Kitami Masahiro , Aihara Yu , Takayama Jun , Tamiya Gen , Kikuchi Atsuo , Kure Shigeo , Saitsu Hirotomo , Matsumoto Naomichi , Haginoya Kazuhiro 
Published: May 2024

AbstractKIF1A‐related disorders (KRDs) encompass recessive and dominant variants with wide clinical variability. Recent genetic investigations have expanded the clinical phenotypes of heterozygous KIF1A variants. However, there have been a few long‐term observational studies of patients with heterozygous KIF1A variants. A retrospective chart review of consecutive patients diagnosed with spastic paraplegia at Miyagi Children's Hospital from 2016 to 2020 identified six patients with heterozygous KIF1A variants. To understand the long‐term changes in clinical symptoms, we examined these patients in terms of their characteristics, clinical symptoms, results of electrophysiological and neuroimaging studies, and genetic testing. The median follow‐up period was 30 years (4–44 years). This long‐term observational study showed that early developmental delay and equinus gait, or unsteady gait, are the first signs of disease onset, appearing with the commencement of independent walking. In addition, later age‐related progression was observed in spastic paraplegia, and the appearance of axonal neuropathy and reduced visual acuity were characteristic features of the late disease phenotype. Brain imaging showed age‐related progression of cerebellar atrophy and the appearance of hyperintensity of optic radiation on T2WI and FLAIR imaging. Long‐term follow‐up revealed a pattern of steady progression and a variety of clinical symptoms, including spastic paraplegia, peripheral neuropathy, reduced visual acuity, and some degree of cerebellar ataxia. Clinical variability between patients was observed to some extent, and therefore, further studies are required to determine the phenotype–genotype correlation.
Asymmetric 1,n‐Remote Aminoacetoxylation of Unactivated Internal Alkenes Enabled by Palladium Catalysis
Authors: Yang Xintuo , Chen Pinhong , Liu Guosheng 
Published: May 2024

AbstractA palladium‐catalyzed asymmetric 1,n‐remote aminoacetoxylation of cis‐alkenes has been developed using PhI(OAc)2 as an oxidant, providing the acetoxylated lactams with excellent enantioselectivities under mild reaction conditions. The sterically hindered pyridine‐oxazoline (Pyox) L3 with a tert‐butyl group in oxazoline ring and propyl group in C6 position of pyridinyl is vital for the reaction, where the former is good for asymmetric aminopalladation step and the latter for the chain walking process. The enantioenriched lactam products were proven to be good building blocks for the synthesis of azabicycles.
Mössbauer study of iron oxide nanoparticles
Authors: Karra Christina , Sarafidis Charalampos 
Published: May 2024

AbstractMagnetic nanoparticles have recently attracted attention for biochemical and medical applications like drug delivery and hyperthermia for a variety of reasons with most important being their stability, chemical compatibility, and suitable magnetic properties like moderate specific mass magnetization. Cobalt ferrites are a well‐studied family of materials and the partial substitution of Fe3+ cations by rare earth (RE) ones may be used to tune the magnetic properties. In the present work pure and substituted Co ferrite nanoparticles with nominal stoichiometry CoFe2−xRxO4 (R = Yb, Gd; x = 0.05, 0.1, 0.3) synthesized by the co‐precipitation method are studied with 57Fe Mössbauer spectroscopy to determine the incorporation of RE ions in the spinel lattice. The fitting procedure was based on the standard spinel model using two sextets for the octahedral and the tetrahedral coordinated positions of Fe atoms. All isomer shift values were found within the typical range of high spin ferric ions while quadrupole splitting values strongly suggest that there is a substitution preference; RE ions replace iron ones in octahedral sites. The inversion parameter was found to decrease with RE content (lowest value about 0.534 for CoFe1.90Yb0.10O4) and thermal treatment always results in changing the material toward normal spinel, while pure CoFe2O4 was inverse. Thermal treatment of substituted materials in ambient air at temperature range 1500–1700 K for 12 h increase crystallite size and changes the degree of inversion.
Theoretical insights toward a highly responsive AgInSe2 photodetector
Authors: Ebon Md. Islahur Rahman , Abir Ahnaf Tahmid , Pathak Dinesh , Hossain Jaker 
Published: May 2024

AbstractThis treatise showcases the design as well as modeling about a photodetector (PD) based on AgInSe2 (AISe), a direct bandgap chalcopyrite with a bandgap of 1.19 eV. The PD exhibits outstanding optical and electronic characteristics, showcasing remarkable performance. The PD has been systematically investigated by varying the width, carrier density, and defect densities of specific layers, as well as the interface defect density of specific interfaces. Various layers are optimized to enhance the overall performance of the PD and the impact of different device resistances is analyzed. The photocurrent (JSC) and voltage (VOC) of the heterostructure photodetector are determined to be 38.60 mA/cm2 and 1.0 V, in turn. The maximum responsivity (R) and detectivity (D*) are identified as 0.70 A/W and 4.60 × 1016 Jones, respectively at a wavelength of 940 nm. The spectral response exhibits significantly higher values in the range of 800–1000 nm, indicating the device's capability to detect near‐infrared (NIR) light. This research provides valuable insights for the manufacturing of AISe material‐based photodetectors with enhanced performance.
Black, indigenous, and people of color's experiences of discrimination in psychoanalytic professional organizations in the USA: Results of a thematic analysis of interview data
Authors: Carter Carter , Crath Rory , Tronnier Christine , Bhargava Harshita , Espinosa‐Setchko Alison , Galeota Julia , Garcia‐Geary Q. , Lasheen Tara , Sencherey Diana , Steindler Rachel 
Published: May 2024

AbstractThis article reviews the results of a qualitative study of Black, indigenous, and people of color (BIPOC)'s experiences of discrimination in psychoanalytic professional organizations (PPOs) in the USA. The authors used thematic analysis to analyze the transcripts of semi‐structured interviews with n = 10 self‐identified BIPOC with prior experience in PPOs, including psychoanalytically‐oriented graduate programs, psychoanalytic institutes and other training programs, and professional membership organizations across the United States. A key finding is that a significant majority of interviewees (n = 9) reported experiencing discrimination in these organizations, per their own definitions of the term “discrimination,” and described these experiences in considerable detail. The authors attempt to triangulate the findings of the present study in relation to the findings of the Holmes Commission and other existing literature on BIPOC experiences in psychoanalysis.
Patterns in abundance, size and space‐use of Giant Mud Crab (Scylla serrata) in a temperate marine protected area
Authors: Hewitt Daniel E. , Johnson Daniel D. , Erskine Luke , Harasti David , Suthers Iain M. , Taylor Matthew D. 
Published: May 2024

Abstract

Marine Protected Areas limit fishing to protect a broad range of species and enhance biodiversity. Consequently, closures may not benefit species equally and species‐specific assessments are required to determine the impact of closures.
Relative abundance and size of Giant Mud Crab (Scylla serrata) was compared across no‐take and fished zones in Port Stephens‐Great Lakes Marine Park, on the temperate east coast of Australia (32.45°S). In addition, passive acoustic telemetry was used to estimate daily space‐use areas.
Similar abundances were observed between no‐take and fished zones; however certain no‐take sites had higher abundances than others. In addition, crabs were 9.9 mm larger in no‐take zones on average. Daily crab space‐use varied widely (~4 to 1000 m2), and generally increased with water temperature and conductivity.
These patterns indicate that recruitment processes interact with marine park protection to shape crab abundances across estuaries. However no‐take zoning appears to primarily limit fishing mortality on legal size crabs (i.e., carapace length >85 mm) resulting in larger crabs within no‐take zones. This may mean no‐take zones enhance reproductive output of crab populations since larger individuals are likely to be more fecund.