bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of political party affiliation as a means to enhance gender equality and women’s political participation in Kazakhstan
Authors: Nurbayev Zhaslan Yesseyevich , Sultangazy Gulmira Zholmagambetovna , Serikbayev Bauyrzhan Serikovich 
Published: May 2024

PurposeThe article aims to identify the main mechanisms for promoting more Kazakhstani women participation in the legislative authorities based on a study of the competition of political parties in 2023.Design/methodology/approachUtilizing the structural-biographical method, the article investigates the ways of increasing women’s participation in the political life of Kazakhstan. This empirical study comprises a total of 18 biographies of women deputies / candidates on party lists who were elected to the legislative body. Content analysis was also conducted to investigate the pre-election programs of the political parties.FindingsThis study has identified that political party is the main resource for promoting gender equality and involving women in the decision-making process. All 18 women deputies of the Mazhilis, the lower house of parliament, are members of political parties. The findings show that women candidates without party affiliation were unable to get into representative body. The results of the election campaign of 2023 provided evidence for determining the gender order in the Kazakhstani political space. The party has become an effective channel for promoting women participations in the parliament of the country. By comparison, in single-mandate constituencies no woman was able to pass to the elected body.Originality/valueThis study contributes to the literature of gender equality and women’s political participation in Kazakhstan and may be relevant for other countries. It also has practical significance and policy implications for the government and political parties.
Developments and implications of tourism information technology: a horizon 2050 paper
Authors: Law Rob , Chen Sirong 
Published: May 2024

Purpose
This study aims to provide an overview of the development of tourism information technology from a macro perspective of the chronological lineage of tourism and information technology from its origins to the present. This study also explores the progression of tourism information technology, its implications and its future directions based on a macro environmental analysis framework comprising political, economic, social, technological, environmental and legal perspectives.

Design/methodology/approach
This study serves as a valuable connection between theoretical knowledge and practical application, combining the experiences of academic researchers and industry practitioners to thoroughly examine the progress and developments in tourism information technology. This research also identifies critical points in the domain to provide a unified and comprehensive explanation that aligns with the current research findings.

Findings
This research reveals the continuous timeline of tourism and information technology development. It discusses the origins, progress and interactions of tourism and information technology, revealing the structural political, economic, social, technological, environmental and legal drivers of tourism information technology. This paper also presents suggestions for future agendas on the basis of a compendium and outlook of influences and implications for the domain.

Originality/value
Findings of this study set the foundation for a comprehensive analysis of the transformative influence of information technology on tourism and provide a contextual framework and insightful future agenda guide for subsequent academic and industry exploration and analysis of tourism information technology.
The capacity of sentinel species to detect changes in environmental conditions and ecosystem structure
Authors: Clark‐Wolf T. J. , Holt Katie A. , Johansson Erik , Nisi Anna C. , Rafiq Kasim , West Leigh , Boersma P. Dee , Hazen Elliott L. , Moore Sue E. , Abrahms Briana 
Published: May 2024

Abstract

A major obstacle to preventing and reversing biodiversity loss in the Anthropocene lies in the scarcity of tools and data for monitoring the health and trajectory of ecosystems. Sentinel species can provide insight into unobserved ecosystem change, but it is unclear how effective sentinels are due to the local, context‐dependent nature of past research.

Here, we present the first global evaluation on the effectiveness of sentinel species as indicators of ecosystem change. We conducted a meta‐analysis on 372 case studies to identify the ecological and methodological factors that correlate with the most effective sentinel species.

Sentinel performance did not vary consistently across taxa or system; instead, sentinels that were more directly linked to ecosystem change due to their trophic role as predators were more effective. In addition, sentinel responses that were measured on a shorter timescale were more effective at indicating ecosystem change.

Policy Implications. These results contribute to the longstanding debate on “what makes a good sentinel” and demonstrate the importance of both ecological and methodological factors when selecting sentinels to detect ecosystem change. For example, sentinel species which are trophically linked and measured on short timescales may be more effective for managers seeking to monitor ecosystem change than other species. By identifying effective traits for the use of sentinel species, scientists and policymakers will be able to develop rapid and adaptable management plans in response to global change.
Intragenic MFSD8 duplication and histopathological findings in a rabbit with neuronal ceroid lipofuscinosis
Authors: Christen Matthias , Gregor Katharina M. , Böttcher‐Künneke Ariane , Lombardo Mara S. , Baumgärtner Wolfgang , Jagannathan Vidhya , Puff Christina , Leeb Tosso 
Published: May 2024

AbstractNeuronal ceroid lipofuscinoses (NCL) are among the most prevalent neurodegenerative disorders of early life in humans. Disease‐causing variants have been described for 13 different NCL genes. In this study, a refined pathological characterization of a female rabbit with progressive neurological signs reminiscent of NCL was performed. Cytoplasmic pigment present in neurons was weakly positive with Sudan black B and autofluorescent. Immunohistology revealed astrogliosis, microgliosis and axonal degeneration. During the subsequent genetic investigation, the genome of the affected rabbit was sequenced and examined for private variants in NCL candidate genes. The analysis revealed a homozygous ~10.7 kb genomic duplication on chromosome 15 comprising parts of the MFSD8 gene, NC_013683.1:g.103,727,963_103,738,667dup. The duplication harbors two internal protein coding exons and is predicted to introduce a premature stop codon into the transcript, truncating ~50% of the wild‐type MFSD8 open reading frame encoding the major facilitator superfamily domain containing protein 8, XP_002717309.2:p.(Glu235Leufs*23). Biallelic loss‐of‐function variants in MFSD8 have been described to cause NCL7 in human patients, dogs and a single cat. The available clinical and pathological data, together with current knowledge about MFSD8 variants and their functional impact in other species, point to the MFSD8 duplication as a likely causative defect for the observed phenotype in the affected rabbit.
Morphometric and histopathological evaluation of modified Elnady's plastinated tissue compared to non‐plastinated tissue: Highlighting its relevance for teaching and research
Authors: Ahmed Osama , Gaballa Mohamed M. S. , Abumandour Mohamed M. A. , Al‐Otaibi Aljohara M. , Choudhary Priyanka , El‐Shafey Anwar A. 
Published: May 2024

AbstractThe present study aims to evaluate the morphometric and histopathological properties of Modified Elnady's plastinated tissue after a period compared to non‐plastinated tissue. The plastination technique is utilized in research and teaching due to the potential health risks associated with prolonged exposure to formalin. The tissues and organs are permanently dried during plastination and can be used for further anatomical, histopathological and surgical educational purposes. This method involves drying tissue and allowing synthetic materials like glycerin to permeate it. The study compared non‐plastinated and plastinated tissue post‐plastination to determine if structural alterations differed from those linked to plastination. The study examined the histopathological examination of dogs' skin, muscles, liver, lung, and intestine using formalin‐fixed organs for paraffin embedding and previously plastinated organs for a plastinated group. The study examined non‐plastinated and plastinated tissues, their histological composition and biometric parameters revealing typical structures in the non‐plastinated group. Plasmodiumted tissues exhibited a compacted appearance, volume changes, nuclear clarity, and cytoplasmic hypereosinophilia, with statistical differences between the two groups. The study reveals that plastinated tissues, after 5 years of plastination, maintain their histological architecture well, with some exceptions. Plastinated tissues can be utilized in future microscopic and immunological studies and will be beneficial for teaching and research.
Editorial: Hepatitis C virus eradication improves skeletal muscle mass
Authors: Tian Catherine Jia Lin , Ngu Jing Hieng 
Published: May 2024

LINKED CONTENTThis article is linked to Coelho et al papers. To view these articles, visit https://doi.org/10.1111/apt.17950 and https://doi.org/10.1111/apt.18005
Specialized ovipositor sensilla of Cretaceous wasps (Insecta: Hymenoptera) possibly reveal a unique way of host detection
Authors: Wang Zhen , Vilhelmsen Lars , Rasnitsyn Alexandr P. , Viertler Alexandra , Shih Chungkun , Wen Shanshan , Yang Hongru , Wu Qiong , Zhang Yanjie , Ren Dong , Gao Taiping 
Published: May 2024

AbstractInsects have evolved complex sensory systems that are important for feeding, defence and reproduction. Parasitoid wasps often spend much time and effort in searching for concealed hosts with the help of specialized sensilla. However, the early evolution of such behaviour and sensilla is poorly known. We describe two fossil female wasps, †Tichostephanus kachinensis sp. nov. and †Tichostephanus longus sp. nov., from mid‐Cretaceous Kachin amber. Phylogenetic analyses based on morphological data retrieved †Tichostephanus as deeply nested within Evanioidea and closely related to extant Gasteruptiidae and Evaniidae. Both of these Cretaceous wasps possess features, e.g. coronal tubercles and flexible ovipositor sheaths, that indicate that they might have laid eggs in wood where their larvae possibly parasitized insect larvae. They have a peculiar and unique ‘bottle brush’ of sensilla close to the apex of their ovipositor sheaths, which has not been observed in any extant parasitoid wasps. These sensilla comprise many regularly arranged plate‐shaped setae, attached in relatively large sockets and with rows of longitudinal ridges. Such specialized sensilla perhaps served to enhance the ability to detect hosts inside wood.
Granulomatous dermatitis in the context of chronic myelomonocytic leukemia: More than just reactive infiltrates. An illustrative case report with literature review
Authors: García‐García Mar , Elbaile Julia Jiménez , Azaceta Gemma , Lorda Marta , Prieto‐Torres Lucía 
Published: May 2024

AbstractTraditionally, skin involvement in chronic myelomonocytic leukemia (CMML) has been considered to be either specific (leukemia cutis) or non‐specific, with granulomatous dermatitis included in the latter group. More recently, the true nature of the myeloid cells present in the cutaneous infiltrates of this theoretically reactive dermatitis is being clarified with the use of new molecular techniques such as next‐generation sequencing. The same mutations in bone marrow (BM) myeloid neoplastic cells and in the cells of cutaneous infiltrates have been found. We present the case of a 77‐year‐old man who presented with spread and treatment‐resistant skin granulomatous lesions previous to the diagnosis of CMML. The same clonal mutations in SRSF2, IDH1, and RUNX1 were found in both skin and BM with resolution of the lesions after the initiation of azacytidine. In conclusion, we report an exceptional case in which specific granulomatous cutaneous lesions have preceded and allowed the earlier diagnosis of an underlying CMML and a review of all previous similar cases in the literature, including molecular alterations.
Effect of Pelargonium graveolens essential oil and cyantraniliprole on the feeding behavior of Bemisia tabaciMED
Authors: dos Santos Maria Clezia , Lima Ana Paula , Farias Adriano Pimentel , Santana Alisson Silva , Prado Maluta Nathalie , Lourenção André Luiz , Antônio Bernardes Wagner , Baldin Edson Luiz Lopes , Lopes João Roberto Spotti 
Published: May 2024

AbstractThe sweet potato whitefly, Bemisia tabaci MED (Gennadius) (Hemiptera: Aleyrodidae), is highly harmful to solanaceous crops. The use of essential oils (EOs) is promising for the management of several insect pests, promoting both lethal and sublethal effects. This study aimed to evaluate the effects of sublethal concentrations of Pelargonium graveolens L'Her (Geraniaceae) EO on the feeding behavior of B. tabaci MED on tomato plants (Solanum lycopersicum L., Solanaceae). For this research, the electrical penetration graph (EPG) technique was used to monitor whitefly stylet activities on their host plants. Two sets of plants were previously sprayed with two concentrations of EO (the LC25 and LC50, which were determined in a mortality test), a third set was treated with the insecticide cyantraniliprole, and a fourth set received a control treatment. Our results indicate that the insecticide cyantraniliprole and the EO could both reduce the stylet feeding activity of B. tabaci MED, as well as reduce the number and duration of phloem sap ingestion events (waveform E2), which could avoid or reduce the transmission of viruses. Thus, the application of sublethal concentrations of P. graveolens EO, as well as exposure to cyantraniliprole, negatively affected the feeding behavior of B. tabaci MED. This information may contribute to the management of this pest and the reduction of the incidence of viruses in tomato production.
Resistance training and combined resistance and aerobic training as a treatment of depression and anxiety symptoms in young people: A systematic review and meta‐analysis
Authors: Marinelli Ryan , Parker Alexandra G. , Levinger Itamar , Bourke Matthew , Patten Rhiannon , Woessner Mary N. 
Published: May 2024

AbstractAimTo determine the treatment effect of resistance training in reducing symptoms of anxiety and depression in young people.MethodsWe searched MEDLINE, PsychINFO, and PubMed for articles published in English from January 1980 to September 2023 for randomized controlled trials (RCT) that included at least 4 weeks of resistance training, with participants aged 26 years or younger with clinically elevated anxiety and depression symptoms. A random‐effects meta‐analysis was used to calculate a pooled effect size of resistance training pre‐and post‐intervention compared to control groups. The quality of evidence was assessed using the Cochrane risk‐of‐bias 2 (RoB 2) and Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) criteria.ResultsTen RCTs involving 376 participants (209 females and 127 males) across educational, clinical, and community based setting were eligible for inclusion in the analysis. Resistance training was associated with a significant reduction in depressive (Hedge's g = −1.06, 95% CI −1.61 to −0.51, p < .001) and anxiety (Hedge's g = −1.02, 95% CI −1.50 to −0.54, p < .001) symptoms. Substantial heterogeneity was observed in the analysis of depression symptoms (I2 = 79%) and anxiety symptoms (I2 = 66%). Six trials had a low risk of bias, four trials showed some concerns. The GRADE analysis demonstrated a high level of certainty for depressive symptoms and a moderate level for anxiety symptoms.ConclusionResistance training is an effective intervention in reducing depression and anxiety symptoms in young people, delivered across a range of settings. Future trials exploring the effect resistance training interventions with long‐term follow up are warranted to understand the outcomes.
Gastrodin regulates the expression of renin‐angiotensin system–SIRT3 and proinflammatory mediators in reactive astrocytes via activated microglia
Authors: Zuo Han‐Jun , Ren Xue‐Qi , Shi Jin‐Sha , Shi Hao‐Long , Guo Kun , Wang Peng‐Xiang , Zhao Min , Li Juan‐Juan 
Published: May 2024

AbstractGastrodin, an anti‐inflammatory herbal agent, is known to suppress microglia activation. Here, we investigated whether it would exert a similar effect in reactive astrocytes and whether it might act through the renin‐angiotensin system (RAS) and sirtuin 3 (SIRT3). Angiotensinogen (ATO), angiotensin‐converting enzyme (ACE), angiotensin II type 1 (AT1) and type 2 (AT2) receptor and SIRT3 expression was detected in TNC‐1 astrocytes treated with BV‐2 microglia conditioned medium (CM) with or without gastrodin and lipopolysaccharide (LPS) pre‐treatment by RT‐PCR, immunofluorescence and western blotting analysis. Expression of C3 (A1 astrocyte marker), S100A10 (A2 astrocyte marker), proinflammatory cytokines and neurotrophic factors was then evaluated. The results showed a significant increase of ATO, ACE, AT1, SIRT3, C3, proinflammatory cytokines and neurotrophic factors expression in TNC‐1 astrocytes incubated in CM + LPS when compared with cells incubated in the CM, but AT2 and S100A10 expression was reduced. TNC‐1 astrocytes responded vigorously to BV‐2 CM treated with gastrodin + LPS as compared with the control. This was evident by the decreased expression of the abovementioned protein markers, except for AT2 and S100A10. Interestingly, SIRT3, IGF‐1 and BDNF expression was enhanced, suggesting that gastrodin inhibited the expression of RAS and proinflammatory mediators but promoted the expression of neurotrophic factors. And gastrodin regulated the phenotypic changes of astrocytes through AT1. Additionally, azilsartan (a specific inhibitor of AT1) inhibited the expression of C3 and S100A10, which remained unaffected in gastrodin and azilsartan combination treatment. These findings provide evidence that gastrodin may have a therapeutic effect via regulating RAS–SIRT3.
It's time to broaden what we consider a ‘blue carbon ecosystem’
Authors: James Kelly , Macreadie Peter I. , Burdett Heidi L. , Davies Ian , Kamenos Nicholas A. 
Published: May 2024

AbstractPhotoautotrophic marine ecosystems can lock up organic carbon in their biomass and the associated organic sediments they trap over millennia and are thus regarded as blue carbon ecosystems. Because of the ability of marine ecosystems to lock up organic carbon for millennia, blue carbon is receiving much attention within the United Nations' 2030 Agenda for Sustainable Development as a nature‐based solution (NBS) to climate change, but classically still focuses on seagrass meadows, mangrove forests, and tidal marshes. However, other coastal ecosystems could also be important for blue carbon storage, but remain largely neglected in both carbon cycling budgets and NBS strategic planning. Using a meta‐analysis of 253 research publications, we identify other coastal ecosystems—including mud flats, fjords, coralline algal (rhodolith) beds, and some components or coral reef systems—with a strong capacity to act as blue carbon sinks in certain situations. Features that promote blue carbon burial within these ‘non‐classical’ blue carbon ecosystems included: (1) balancing of carbon release by calcification via carbon uptake at the individual and ecosystem levels; (2) high rates of allochthonous organic carbon supply because of high particle trapping capacity; (3) high rates of carbon preservation and low remineralization rates; and (4) location in depositional environments. Some of these features are context‐dependent, meaning that these ecosystems were blue carbon sinks in some locations, but not others. Therefore, we provide a universal framework that can evaluate the likelihood of a given ecosystem to behave as a blue carbon sink for a given context. Overall, this paper seeks to encourage consideration of non‐classical blue carbon ecosystems within NBS strategies, allowing more complete blue carbon accounting.
Is celebration of New Year and other festivals worth their environmental impact?
Authors: Islam Md. Ziaul 
Published: May 2024

AbstractThe global tradition of fireworks at festivals causes significant environmental harm, including air, water, noise and light pollution, and impacts on human health. Diwali and the Chinese New Year fireworks can spike the Air Quality Index and elevate particulate matter (PM2.5) concentrations in capitals during and after celebrations. This commentary examines evidence for the detrimental effects of fireworks on the environment, human health and wildlife. Alternatives like drone displays, laser shows and eco‐friendly decorations are proposed, along with stricter regulations to curb firework impacts.
Characterising bioactive components of green‐lipped mussel via two extraction methods: in vitro assessment of antioxidant and immunomodulatory effects
Authors: Cardim Lessa Roberta , Ebrahimi Belgheis , Jury Jenn , Sewell Mary , Xie Yiqi , Li Yan , Lu Jun 
Published: May 2024

SummaryThis study investigates the benefits of green‐lipped mussels containing bioavailable PUFAs and inflammation‐modulating oil extracts. The goal is to find the best method for extracting lipids from two types of raw materials with strong immunomodulatory, anti‐inflammatory and antioxidant properties using organic solvents and supercritical carbon dioxide (CO2) techniques. The lipid classes are analysed using TLC‐FID and GC–MS to detect FFAs, while DPPH determines antioxidant levels. The cytokine production of IL‐6 and TNF‐α in LPS‐stimulated mouse macrophages is measured using ELISA. The results show that while supercritical CO2 is the most effective method for extracting lipids, the content can vary depending on the source and technique. The major FFAs found include EPA, Palmitic acid, DHA, and Palmitoleic acid, with PUFAs, particularly omega 3, being the most dominant. Samples exhibit potent radical scavenging in 2000 μg mL−1, similar to ascorbic acid at 62.5 μg mL−1 (62.2 ± 15.36%). The cells release more TNF‐α than IL‐6, and solvent extraction was found to regulate the immune response more effectively. In conclusion, the extracts contain significant amounts of EPA/DHA and variable FFAs, suggesting potential anti‐inflammatory effects. However, further validation in alternative in vitro models is necessary.