bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sedimentary and metamorphic processes priming black shale for magmatic assimilation of sulfur: an example from the Virginia Formation, Minnesota, United States
Authors: Virtanen Ville J. , Heinonen Jussi S. , Märki Lena , Galvez Matthieu E. , Molnár Ferenc 
Published: April 2024

Abstract
The copper-nickel(-platinum-group element) sulfide resources of the Duluth Complex, Minnesota, USA, formed by assimilation of sulfur from the Virginia Formation black shale. In the normal black shale of the Virginia Formation, sulfur is mainly hosted in disseminated pyrite, whereas mm-scale pyrrhotite laminae dominate in the sulfur-rich Bedded Pyrrhotite Unit. The Bedded Pyrrhotite Unit was the main supply of sulfur in some of the magmatic sulfide deposits but its origin has not been studied in detail. Using Raman spectroscopy, we show that the carbonaceous material within the regionally metamorphosed normal black shale is graphitized biogenic material. The Bedded Pyrrhotite Unit contains pyrobitumen that represents residues of oil that accumulated to porous horizons, which formed due to dissolution of precursor sedimentary clasts. Replacement of the clasts by quartz and sulfides facilitated the formation of the pyrrhotite laminae of the Bedded Pyrrhotite Unit, which likely occurred during regional metamorphism.
The pyrite-bearing normal black shale experienced loss of H2O, Corg, and sulfur during devolatilization caused by the Duluth Complex. The contact-metamorphosed Bedded Pyrrhotite Unit shows no systematic depletion of volatiles and is the most Corg and sulfur-rich part of the Virginia Formation. During devolatilization, sulfur was preserved because unlike pyrite, pyrrhotite was stable. Consequently, magmatic assimilation of sulfur from the Bedded Pyrrhotite Unit required partial melting. Retrograde hydration introduced H2O, and possibly Corg, and sulfur, to the contact-metamorphosed Bedded Pyrrhotite Unit, which further affected the volatile budget. Our findings highlight why constraining diagenetic and regional metamorphic processes is important to understand magma-sediment interaction processes.
Axiomatic characterizations of the core and the Shapley value of the broadcasting game
Authors: Bergantiños Gustavo , Moreno-Ternero Juan D. 
Published: April 2024

AbstractWe study the cooperative game associated with a broadcasting problem (the allocation of revenues raised from the collective sale of broadcasting rights for a sports tournament). We show that the set of core allocations can be characterized with three axioms: additivity, null team and monotonicity. We also show that the Shapley value can be characterized with additivity, equal treatment of equals and core selection.
Gluing Small Black Holes into Initial Data Sets
Authors: Hintz Peter 
Published: April 2024

AbstractWe prove a strong localized gluing result for the general relativistic constraint equations (with or without cosmological constant) in $$n\ge 3$$

n
≥
3

spatial dimensions. We glue an $$\epsilon $$
ϵ
-rescaling of an asymptotically flat data set $$({\hat{\gamma }},{\hat{k}})$$

(

γ
^

,

k
^

)

into the neighborhood of a point $$\mathfrak {p}\in X$$

p
∈
X

inside of another initial data set $$(X,\gamma ,k)$$

(
X
,
γ
,
k
)

, under a local genericity condition (non-existence of KIDs) near $$\mathfrak {p}$$
p
. As the scaling parameter $$\epsilon $$
ϵ
tends to 0, the rescalings $$\frac{x}{\epsilon }$$

x
ϵ

of normal coordinates x on X around $$\mathfrak {p}$$
p
become asymptotically flat coordinates on the asymptotically flat data set; outside of any neighborhood of $$\mathfrak {p}$$
p
on the other hand, the glued initial data converge back to $$(\gamma ,k)$$

(
γ
,
k
)

. The initial data we construct enjoy polyhomogeneous regularity jointly in $$\epsilon $$
ϵ
and the (rescaled) spatial coordinates. Applying our construction to unit mass black hole data sets $$(X,\gamma ,k)$$

(
X
,
γ
,
k
)

and appropriate boosted Kerr initial data sets $$({\hat{\gamma }},{\hat{k}})$$

(

γ
^

,

k
^

)

produces initial data which conjecturally evolve into the extreme mass ratio inspiral of a unit mass and a mass $$\epsilon $$
ϵ
black hole. The proof combines a variant of the gluing method introduced by Corvino and Schoen with geometric singular analysis techniques originating in Melrose’s work. On a technical level, we present a fully geometric microlocal treatment of the solvability theory for the linearized constraints map.
Sphingomonas lacusdianchii sp. nov., an attached bacterium inhibited by metabolites from its symbiotic cyanobacterium
Authors: Wang Xin , Xiao Yao , Deng Yang , Sang Xue , Deng Qing-Lin , Wang Le , Yang Yi-Wen , Zhang Bing-Huo , Zhang Yu-Qin 
Published: April 2024

Abstract
An alpha-proteobacterial strain JXJ CY 53 T was isolated from the cyanosphere of Microcystis sp. FACHB-905 (MF-905) collected from Lake Dianchi, China. JXJ CY 53 T was observed to be an aerobic, Gram-stain-negative, oval shaped, and mucus-secreting bacterium. It had C18:1ω7c and C16:0 as the major cellular fatty acids, Q-10 as the predominant ubiquinone, and sphingoglycolipid, diphosphatidylglycerol, phosphatidylcholine, and phosphatidylmethylethanolamine as the polar lipids. The G + C content of DNA was 65.85%. The bacterium had 16S rRNA gene sequence identities of 98.9% and 98.7% with Sphingomonas panni DSM 15761 T and Sphingomonas hankookensis KCTC 22579 T, respectively, while less than 97.4% identities with other members of the genus. Further taxonomic analysis indicated that JXJ CY 53 T represented a new member of Sphingomonas, and the species epithet was proposed as Sphingomonas lacusdianchii sp. nov. (type strain JXJ CY 53 T = KCTC 72813 T = CGMCC 1.17657 T). JXJ CY 53 T promoted the growth of MF-905 by providing bio-available phosphorus and nitrogen, plant hormones, vitamins, and carotenoids. It could modulate the relative abundances of nonculturable bacteria associated with MF-905 and influence the interactions of MF-905 and other bacteria isolated from the cyanobacterium, in addition to microcystin production characteristics. Meanwhile, MF-905 could provide JXJ CY 53 T dissolved organic carbon for growth, and control the growth of JXJ CY 53 T by secreting specific chemicals other than microcystins. Overall, these results suggest that the interactions between Microcystis and its attached bacteria are complex and dynamic, and may influence the growth characteristics of the cyanobacterium. This study provided new ideas to understand the interactions between Microcystis and its attached bacteria.

Key points
• A novel bacterium (JXJCY 53T) was isolated from the cyanosphere of Microcystis sp. FACHB-905 (MF-905)
• JXJCY 53Tmodulated the growth and microcystin production of MF-905
• MF-905 could control the attached bacteria by specific chemicals other than microcystins (MCs)
Impacts of preoperative anxiety and depression on pain and range of motion after arthroscopic frozen shoulder release: a cohort study
Authors: Haroun Yahia , Younis Ahmed Saeed , Ebied Wessam Fakhery , Hemida Mohamed Amr , Khater Ahmed H. 
Published: April 2024

Abstract
Purpose
We aimed to evaluate the impact of preoperative anxiety and depression levels on baseline and postoperative pain in patients who underwent arthroscopic frozen shoulder release.

Methods
The study included 59 patients with more than three months of idiopathic frozen shoulder. All patients had arthroscopic frozen shoulder release. Two patients were excluded from statistical analysis. Therefore, the statistical analysis was performed on the remaining 57 patients. The patients were divided into two groups according to HADS scores: group 1 which included 28 patients with a healthy psychological status (anxiety ≤ 7 and depression ≤ 7), and Group 2, which included 29 patients with psychological distress ( anxiety ≥ 8 or depression ≥ 8).

Results
The hallmark finding of this study is that patients complaining of frozen shoulder symptoms and having psychological distress (HADS ≥ 8) experienced higher pain scores preoperatively and at one-year follow-up after arthroscopic release. All patients showed significant improvement between the preoperative period and the one year follow-up regarding the abduction, forward flexion, external rotation at the side and the VAS pain score with a P value of 0.001.

Conclusions
Arthroscopic frozen shoulder release significantly lowers the VAS pain score over the 12-month.
Condition dependence in the sexual communication system of the túngara frog
Authors: Wilhite Kyle O. , Ryan Michael J. 
Published: April 2024

AbstractSexual selection can result in the evolution of extreme armaments and ornaments, and the development and maintenance of these traits can come at a considerable cost. These costs have been implicated in enforcing an upper limit on trait divergence and promoting condition-dependent traits, such that only individuals in sufficiently high condition can effectively wield these armaments and advertise these ornaments. Numerous studies demonstrate the condition-dependence of sexually selected traits, especially those used by males to advertise to females. In this study, we investigated condition-dependent mating calls in the túngara frog Physalaemus (= Engystomops) pustulosus. We manipulated male condition in the laboratory over a nine-day period by restricting food availability. We then documented: the relationship between male condition (the relative change in body mass from night 1 to night 9) and acoustic parameters of his mating call; how male condition influenced the male’s responses to call playbacks; and finally, how male condition influenced the attractiveness of the male’s calls to females. Males who were not fed during this period showed significant changes in call frequency, duration, and amplitude. In response to playbacks, unfed males called less, and made fewer complex calls. Finally, in phonotaxis experiments, females were more attracted to the calls of unfed males on night 1 to the calls of the same males on night 9. Fed males, on the other hand, showed no significant differences between nights 1 and 9 in call parameters, calling effort, and call attractiveness. This study shows the pervasive effects of condition on three aspects of sexual communication: signal parameters, behavioral response to vocal competition, and mating call attractiveness.
The survival benefit of metastasectomy for metastatic non-clear cell renal cell carcinoma: a retrospective cohort study
Authors: Dai Jindong , He Ben , Zhang Yaowen , Zhang Haoran , Hu Xu , Xu Lijing , Ni Yuchao , Zhang Xingming , Sun Guangxi , Zeng Hao , Shen Pengfei , Liu Zhenhua 
Published: April 2024

Abstract
Purpose
The aim of this study was to explore the benefit the metastasectomy for patients with metastatic non-clear cell carcinoma (non-ccRCC).

Methods
This study enrolled 120 patients with confirmed metastatic non-ccRCC from the RCC database of our center from 2008 to 2021. Patients without metastasectomy were grouped as radical nephrectomy without metastasectomy patients. The clinical outcomes included overall survival (OS) and progression-free survival (PFS). Cox regression and Kaplan–Meier analyses were used to assess potential factors that predict clinical benefits from metastasectomy.

Results
A total of 100 patients received radical nephrectomy alone, while the remaining 20 patients underwent both radical nephrectomy and metastasectomy. There was no significant difference in age between the two groups. Out of 100 patients who underwent radical nephrectomy, 60 were male, and out of 20 patients who had both radical nephrectomy and metastasectomy, 12 were male. Patients who underwent systemic therapy plus radical nephrectomy and metastasectomy had significantly better PFS (27.1 vs. 14.0, p = 0.032) and OS (67.3 vs. 24.0, p = 0.043) than those who underwent systemic therapy plus radical nephrectomy alone. Furthermore, for patients without liver metastasis (n = 54), systemic therapy plus radical nephrectomy and metastasectomy improved both PFS (p = 0.028) and OS (p = 0.043). Similarly, for patients with metachronous metastasis, systemic therapy plus radical nephrectomy and metastasectomy improved both PFS (p = 0.043) and OS (p = 0.032). None of the patients experienced serious perioperative complications (Clavien–Dindo Classification ≥ III grade).

Conclusion
Metastasectomy in patients with metastatic non-ccRCC may provide clinical benefits in terms of improved PFS and OS, especially in patients without liver metastasis and those with metachronous metastasis.
Predictive role of ureteral wall thickness and patient characteristics in endoscopic treatment outcomes for ureteral stricture disease following stone surgery
Authors: Sahin Cahit , Sinanoglu Orhun , Sobay Resul , Arikan Ozgur , Uslu Mehmet , Bicaklioglu Fatih , Sahinler Emre Burak , Yildirim Salih , Bayraktar Zeki , Sarica Kemal 
Published: April 2024

Abstract
Purpose
To evaluate the role of certain radiological parameters and patient characteristics in predicting the success of endoscopic treatment in ureteral stricture disease.

Methods
Fifty one adult patients with ureteral stricture disease (< 1 cm) after developing due to upper ureteral stones with ureteroscopic laser disintegration were included and in addition to stone and patient parameters, radiological parameters including ureteral wall thickness (UWT) at the impacted stone site were also measured on computed tomography (CT) images. Patients were divided into two groups: Group 1: Patients with endoscopic treatment success and Group 2: Patients with endoscopic treatment failure. The possible relationship between the UWT values and other radiological parameter was comparatively evaluated.

Results
Mean UWT value assessed at the treated stone site was significantly higher in cases unresponsive to endoscopic treatment with values of 2.77 ± 1.03 mm and 4.25 ± 1.32 mm in Group 1 and 2 respectively. A cut off value 3.55 mm for UWT was found to be highly predictive for endoscopic treatment failure.

Conclusions
Our current results indicated that assessment of UWT value at the obstructing stone could be helpful enough to predict the likelihood of failure following endoscopic management of strictures with high sensitivity and specificity. Evaluation of this particular parameter could let the endourologists to look for more rational treatment alternatives with necessary measures taken on time.
Systematic evaluation of Merkel cell carcinoma clinical practice guidelines using the AGREE II instrument
Authors: Lakshmipathy Deepak , Fritz Christian , Harris Jacob , Athni Tejas , Go Beatrice , Moreira Alvaro , Giordano Cerrene , Rajasekaran Karthik 
Published: April 2024

AbstractMerkel cell carcinoma (MCC) is a rare type of skin cancer that requires a multidisciplinary approach with a variety of specialists for management and treatment. Clinical practice guidelines (CPGs) have recently been established to standardize management algorithms. The objective of this study was to appraise such CPGs via the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument. Eight CPGs were identified via systematic literature search following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. Four appraisers trained in AGREE II protocols evaluated each CPG and deemed two CPGs as high quality, five as moderate quality, and one as low quality. Intraclass correlation coefficients (ICCs) were calculated to verify reviewer consistency as excellent, good, and moderate across four, one, and one domain, respectively. The majority of MCC CPGs are lacking in specifying stakeholder involvement, applicability, and rigor of development. The two high quality CPGs are from the Alberta Health Services (AHS) and the collaboration between the European Dermatology Forum, the European Association of Dermato-Oncology, and the European Organization of Research and Treatment of Cancer (EDF/EADO/EORTC). The EDF/EADO/EORTC CPG had the highest overall score with no significant deficiencies across any domain. An important limitation is that the AGREE II instrument is not designed to evaluate the validity of each CPG’s recommendations; conclusions therefore can only be drawn about each CPG’s developmental quality. Future MCC CPGs may benefit from garnering public perspectives, inviting external expert review, and considering available resources and implementation barriers during their developmental stages.
Effectiveness of atopic dermatitis patient education programs – a systematic review and meta-analysis
Authors: Andrade Luis F. , Abdi Parsa , Mashoudy Kayla D. , Kooner Amritpal , Egler Ashley , Urbonas Rebecca , Smith Aaron , Yosipovitch Gil 
Published: April 2024

AbstractPatient education in atopic dermatitis (AD) has worked in parallel to the gold standard of pharmacological treatment as a foundational component of therapeutic regimens. In addition to improving patient education, past investigations of educational interventions have demonstrated profound reductions in disease severity for patients living with AD. However, prior meta-analytical work has focused mostly on comparing in-person interventions, and thus the need to determine the effectiveness of virtual methodologies in the current post-COVID era remains. In this study, we conducted a systematic review of the literature to determine the effectiveness of online programming in AD education compared to in-person interventions. A comprehensive search was conducted in accordance with the Cochrane Handbook for Systematic Reviews of Interventions 2019. Studies were retrieved based on articles published up to 04 April 2023. Adherence to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement guided the reportage process for this systematic review and meta-analysis. The primary outcome of our meta-analysis was the effect of various educational modalities on atopic dermatitis severity as measured by multiple scales across the studies, the most common including SCORAD, Dermatology Life Quality Index (DLQI), Patient Oriented Eczema Measure (POEM), and Eczema Area and Severity Index (EASI). Most studies were randomized controlled trials, primarily from North America and Western Europe and focused on patient and/or caregiver education about disease management, self-care techniques, avoidance of triggers, and comprehensive understanding of the disease process. Our pooled analyses showed that targeted educational programs in understudied adult populations can be as impactful as those in pediatric groups. Moreover, virtual interventions can be employed as constructive tools for reducing barriers of access to patient education. Future research on educational interventions should utilize various methodologies to encourage individual learning preferences with a focus on adult cohorts.
Gynecologic perivascular epithelioid cell tumors (PEComas): a review of recent evidence
Authors: Levin Gabriel , Capella Mariana Pilon , Meyer Raanan , Brezinov Yoav , Gotlieb Walter H 
Published: April 2024

AbstractGynecologic perivascular epithelioid cell (PEC) tumors, or 'PEComas,' represent a rare and intriguing subset of tumors within the female reproductive tract. This systematic literature review aims to provide an updated understanding of gynecologic PEComas based on available literature and data. Although PEComa is rare, there are varied tumor-site presentations across gynecologic organs, with uterine PEComas being the most prevalent. There is scarce high-quality literature regarding gynecologic PEComa, and studies on malignant PEComa underscore the challenges in diagnosis. Among the diverse mutations, mTOR alterations are the most prominent. Survival analysis reveals a high rate of local recurrence and metastatic disease, which commonly affects the lungs. Treatment strategies are limited, however mTOR inhibitors have pivotal role when indicated and chemotherapy may also be used. with some cases demonstrating promising responses. The paucity of data underscores the need for multicentric studies, an international registry for PEComas, and standardized reporting in case series to enhance clinical and pathological data.
Clinical and genetic studies for a cohort of patients with Leber congenital amaurosis
Authors: Zhou Yunyu , Huang Lijuan , Xie Yan , Liu Wen , Zhang Shasha , Liu Lili , Lin Ping , Li Ningdong 
Published: April 2024

Abstract
Purpose
Leber congenital amaurosis (LCA) is a group of early-onset retinal degenerative disorders, resulting in blindness in children. This study aimed to describe the clinical and genetic characteristics of a cohort of patients with LCA and to investigate the retinal vascular characteristics in LCA patients.

Methods
Fifty-two children with LCA were included in the study. All patients underwent detailed ocular examinations. Electroretinography (ERG) was used to evaluate the retinal function. Optical coherence tomography (OCT) was used to assess the structure change of the retina for those patients who were able to cooperate very well. Panel-based next-generation sequencing was performed to identify pathogenic variants in genes associated with LCA. Diameters of the retinal vessels were measured using the EVision AI screening system with an artificial intelligence (AI) technique. An ultrasound Doppler was used to evaluate hemodynamic parameters, including peak systolic velocity (PSV), resistive index (RI), and pulsatility index (PI), in the ophthalmic, central retinal, posterior ciliary, carotid, and internal carotid as well as external carotid arteries in 12 patients aged from 3 to 14 years.

Results
We detected 75 pathogenic variants from ten genes of RPGRIP1, CEP290, GUCY2D, LCA5, AIPL1, CRB1, RPE65, CRX, RDH12, and TULP1, including 29 novel and 36 previously reported variants in 52 affected children with LCA, with the highest detective rate in RPGRIP1 (26.9%). Fundus appearance is diverse in patients with LCA, ranging from normal to severe peripheral or central retinopathy. Retinal vasculature was evaluated in 12 patients with different gene variants, showing narrowed arteries with an average diameter of 43.6 ± 3.8 μm compared to that of 51.7 ± 2.6 μm in the normal controls (P < 0.001, n = 12). Meanwhile, their hemodynamic parameters were changed as well in the ophthalmic artery (OA), with a decreased PSV (P = 0.0132, n = 12) and slightly increased PI (P = 0.0488, n = 12) compared to the normal controls. However, the hemodynamic parameters did not change significantly in the other vessels.

Conclusions
Blood supply to the eyeball is predicted to be reduced in patients with LCA, presumably due to photoreceptor cell degeneration. The novel identified variants will expand the spectrum of variants in LCA-related genes and be useful for studying the molecular mechanisms of LCA.