bluuebunny/crossref_metadata_2025_split huggingface dataset:
The comparison of GNRI versus HALP score as an outcome predictor in geriatric rectal cancer patients
Authors: Fuadhi Singgih Annas , Handaya Adeodatus Yuda , Setyawan Nurcahya , Barmawi Agus , Sofii Imam 
Published: May 2024

Link of Video Abstract: https://youtu.be/mBRqppCkDcM

Background: Colorectal cancer is the third most common cancer worldwide. Along with the development of science and technology, life expectancy has also increased, but the number of geriatric patients with colorectal cancer and undergoing surgery has also increased. Geriatric patients have many factors that can affect the patient's prognosis. Thus, a screening tool to predict the outcome of rectal cancer geriatric is needed.
Methods: An observational analytic study with a retrospective cohort study design. This research was conducted by taking medical record data and laboratory results of patients with rectal cancer treated at Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Data were analyzed using SPSS version 20.0 for Windows.
Results: Patients with malnutrition, decreased hemoglobin levels, albumin, and increased platelets affect mortality and postoperative complications of rectal cancer patients. There was a significant association between the Geriatric Nutritional Risk Index (GNRI) and preoperative Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) scores on mortality and postoperative complications in geriatric patients with rectal cancer (p<0.05). GNRI associated with length of stay in geriatric patients with rectal cancer. However, there is no significant relationship between Hemoglobin, Albumin, Lymphocyte, and Platelet (HALP) preoperative scores on length of stay in geriatric patients with rectal cancer (p>0.05).
Conclusion: Both screening predictors of rectal cancer outcome, namely GNRI and HALP, have a significant relationship with patient mortality and complications.
Telerehabilitation of spinal cord injury in limited resources setting during COVID-19 pandemic: A case report
Authors: Azharuddin  , Novera Diaz 
Published: May 2024

Link of Video Abstract: https://youtu.be/f6IaLnu3sz8

Introduction: Spinal cord injury (SCI) rehabilitation is a resource-intensive and time-consuming process and this is problem in particular for patients from a rural, remote areas, or low socioeconomic backgrounds. This problem is further exacerbated by social restriction policies in place due to coronavirus disease 2019 (COVID-19). This case report aimed to describe how telerehabilitation could overcome these challenges
Case presentation: A 20-year-old female involved in a motor vehicle accident. Preoperative magnetic resonance imaging (MRI) indicated a complete burst fracture of the L1 vertebral body. The patient experiences paraplegia and loss of autonomic control. Long spine fusion was performed. After being discharged, the patient could only visit the hospital once one-month post-surgery due to personal financial reasons and COVID-19-related social distancing policy. Telerehabilitation was used for the remaining follow-ups and rehabilitation programs were monitored through instant messaging platform between the patient, the operating surgeon, and the rehabilitation specialist. Telerehabilitation using instant messaging was an affordable and practical platform of communication for patient self-reporting and monitoring of progress. With intensive telerehabilitation program, the patient’s functional abilities recovered from Frankel B to D after 6 months of following the domiciliary telerehabilitation plan.
Conclusion: We report a case of satisfactory functional outcome of SCI rehabilitation following the use of instant messaging to assist the rehabilitation. This highlights that instant messaging may be utilized to guide the rehabilitation process with the consideration of other factors such as the patient's engagement and the healthcare provider’s commitment. We recommend for further refinements in the adoption and use of telerehabilitation for orthopaedic and traumatology cases that need long-term rehabilitation.
Correlation of serum D-dimer level and the event microvessel cardiac thrombosis observed on core biopsy in post mortem COVID-19 Patients in Dr. Soetomo Hospital Surabaya, Indonesia
Authors: Lefi Achmad , Rinjani Lalu Galih Pratama , Alsagaff Muhammad Yusuf , Budiarto Raden Mohammad , Wiratama Priangga Adi , Kusumastuti Etty Hary , Marhana Isnin Anang , Rosyid Alfian Nur , Wahyu Dwi , Semedi Bambang Pujo , Nugraha Ricardo Adrian , Intan Ryan Ernast , Ramadhan Muhammad , Caesarina Ika , Fadila Asiyah Nurul , Tiyantara Muhammad Surya , Nugroho Gilang Muhammad Setyo , Maimunah Ummi , Suyanto Edi , Anggoro Adhitri , Yandi I Komang Rusgi , Lilihata Jilieanastasia Godrace 
Published: May 2024

Link of Video Abstract: https://youtu.be/ivpwfj9PxWQ

Background: Microvascular coronary thrombosis is an emerging risk factor that worsens the prognosis of COVID-19 patients. This study aims to show for the first time a descriptive of histopathologic findings from post-mortem COVID-19 patients and to analyze whether D-Dimer serum level, a marker of hyper-coagulopathy, correlates with coronary microvascular thrombosis from the cardiac core biopsy.
Method: This was an observational analytic study with a retrospective cohort design from July-December 2020. Cardiac core biopsy was taken from patients who died while treated at the isolation ICU at Dr. Soetomo due to severe COVID-19. The samples were taken in 1-hour post-mortem and then analyzed histopathologically with Hematoxylin-eosin staining under a light microscope to evaluate the presence of coronary microvascular thrombosis and other pathological findings from the cardiac biopsy. Clinical information and D-Dimer levels from medical records and analyzed for coronary microvascular thrombosis using Man-Whitney and C-statistic analysis using SPSS 22 software.
Result: There were 39 samples of post-mortem patients in this study. The majority were men (71.8%), with a mean age of 48.9 years old. Focal microvessel coronary thrombosis was found in 28%). The median D-Dimer level was increased from the average baseline (3460 mg/dl). However, there was no significant difference in D-dimer levels between focal microvessel coronary thrombosis incidents (p-value 0.827, C statistic AUC 0.523). The lack of focal necrosis in the surrounding tissue suggests that the thrombosis resulted from proximal embolization to distal capillary coronary, which already happened before, rather than the primary in-situ process in microvascular, hence may explain why D-Dimer was not correlated with the finding of coronary microvascular thrombosis in this study.
Conclusion: D-dimer serum levels were not associated with focal microvessel thrombi in post-mortem COVID-19 patients. This result supports previous studies that showed D-Dimer was not specific to detect thrombosis in microvascular.
The impact of social media marketing efforts on visit intention: a case study in Flodova Clinic, Dili, Timor Leste
Authors: Gomes Florindo Cardoso , Antonio Ferdi , Laot Perpetua Ana Mery Estela , Gomes Eva Estrelita Cardoso 
Published: May 2024

Link of Video Abstract: https://youtu.be/iDWJ07s4En8

Background: The utilization of social media in digital marketing offers various benefits, notably improved accessibility and the ability to disseminate information widely among diverse populations. Notably, social media has emerged as the leading marketing strategy to generate interest among people visiting healthcare facilities in Timor Leste. This study examines the impact of Social Media Marketing Efforts (SMME) on visit intentions through Flodova Clinic's Facebook page in Timor Leste. The mediating factors of brand image and online trust are investigated while controlling for health threats and gender.
Methods: The study collects data from visitors and Facebook followers of Flodova Clinic. A cross-sectional data collection was done through an online survey. The analysis includes 184 samples that meet the inclusion criteria, employing Partial Least Squares Structural Equation Modeling (PLS-SEM).
Results: The findings demonstrate a significant influence of SMME on visit intentions, indicating its efficacy in attracting potential visitors. However, no direct or mediating effects are observed on brand image and online trust. The study identifies the most influential domains of SMME, with electronic word of mouth (EWOM) having the most substantial impact, followed by entertainment and interaction. Additionally, health threats and gender are found to affect visit intentions significantly. Health threats positively influence patients' intent to visit, while females show comparatively lower interest in visiting the Flodova clinic.
Conclusions: These results have managerial implications for developing SMME strategies in marketing health clinics, mainly through social media platforms like Facebook. The study underscores the importance of leveraging electronic word of mouth, entertainment, and interactive elements to maximize the effectiveness of SMME strategies. Additionally, it emphasizes the need for tailored approaches considering health threats and gender differences to optimize visit intentions and enhance engagement.
Predictor of Mortality in Complicated Intraabdominal Infection Patients at Dr. Soetomo General Hospital Surabaya
Authors: Kurniawan Erwin , Wibowo Marjono Dwi , Danardono Edwin 
Published: May 2024

Link of Video Abstract: https://youtu.be/g_ys7cQCuDYBackground: Complicated intraabdominal infection (cIAI) is a surgical emergency reported to be a major contributor to non-traumatic mortality worldwide. Identifying the mortality risk before any operation is important in guiding clinical decision-making and informed patient consent about the risk of complicated intraabdominal infection (cIAI). The study aimed to develop a novel scoring system for predicting postoperative mortality in cIAI.
Methods: Data were collected retrospectively from all consecutive patients 396 patients met the inclusion criteria after excluding missing data undergoing cIAI surgery in Dr. Soetomo Hospital 2020 - 2022. Multivariate logistic regression analysis was performed to correlate the explanatory variable postoperative mortality. Data were analyzed using SPSS version 20.0 for Windows and MedCalc.
Results: Postoperative mortality rate cIAI was 32,2% (128 of 396), and variables identified as the strongest predictors of postoperative mortality were age > 60 y.o (OR 3,196), systolic blood pressure < 100 mmHg (OR 5,894), thrombocyte < 100.000 /uL (OR 5,593), albumin ≤ 2,9 g/dL (OR 6,764), total bilirubin > 1,8 mg/dL (OR 2,180), creatinine serum ≥ 1,58 mg/dL (OR 4,290), cancer comorbidity (OR 3,578), and appendix perforation as negative predictor (OR 5,853). These parameters were included in the prediction model of the novel simplified Airlangga Scoring System.
Conclusion: Despite the relatively low number of risk factors, the Airlangga score has been shown as a good predictor of postoperative mortality after cIAI. External validation is required in hospitals different from those in which the novel scoring system was developed.
Effect of human granulosa cells vitrification on the expression of oocyte secreted factors
Authors: Batara Sirait  , Budi Wiweko  , R. Muharram  , Ahmad Aulia Jusuf  , Ichramsjah A. Rachman  , Arief Boediono  
Published: May 2024

Background: Oocyte vitrification is a helpful fertility preservation technique for women at risk of losing their ovarian functions. Meanwhile, its application extends with the emerging trend of delayed childbearing, postponed marriage, and further diverse ethical, medical, legal, and social implications. Whereas its effect on oocytes has been widely elucidated, the potential impact of this procedure on the biological functions of granulosa cells remains poorly understood. The present study aimed to assess vitrification’s effect on the granulosa cells (GCs).
Methods: 35 women with polycystic ovary syndromes who underwent in vitro fertilization (IVF) in Morula IVF Jakarta Clinic were recruited. The expression of prominent oocytes secreted factors (OSFs), including GDF-9 and BMP-15, were measured at messenger RNA (mRNA) levels. GCs from mature and immature oocytes were collected and calculated separately. Relative expression of GDF-9 and BMP-15 was quantified by a real-time quantitative PCR (RT-qPCR). All of the data was analyzed by using SPSS. Bivariate analysis used the Mann-Whitney test at a 95% confidence level. A significant p-value was ≤ 0.05.
Results: The mean age of subjects was 32,39 ± 3,33 years old, with the mean duration of infertility being six years. The mean BMI, anti-Mullerian hormone (AMH) level, and antral follicle count (AFC) were 24.04 kg/m2, 3.43 ng/mL, and 15 follicles, respectively. The basal FSH, LH, estradiol, and progesterone were at the normal level. The expression of GDF-9 decreased significantly (0.5-fold, p < 0.01) in the immature vitrified GC group but was not in the mature-vitrified GC group. Meanwhile, the expression of BMP-15 was stable in all examined groups (P>0.05).
Conclusion: Our results suggest that vitrification may alter oocyte maturation, as demonstrated by reduced GDF-9 expression in the immature vitrified GC group.
Eucalyptus oil as adjuvant therapy for coronavirus disease 19 (covid-19): a randomized clinical trial
Authors: Santoso Arif , Rasiha  , Afifah Muthiah Nur , Muhammad Munawir , Sultan Andi Rofian , Juni Muhammad Rezky , Prasetia Priady Wira , Andreza  , Idrus Idrianti , Munawirah Andi , Widaningsih Yuyun , Hamid Firdaus , Paturusi Idrus A. , Massi M. Nasrum , Azis Asrul Abdul , Dharmayanti Niluh Putu Indi , Nuradji Harimurti , Nurjanah Diana , Djufry Fadjry , Safitri Evie 
Published: May 2024

Link of Video Abstract: https://youtu.be/WzYiDQR2RvA

Introduction: The coronavirus disease 19 (COVID-19) vaccination scheme is still being implemented worldwide, but problems with stock availability and other factors are still impeding this endeavor, especially in developing nations like Indonesia. Ethnopharmacology is known to provide a good source of a cheap candidate for anti-inflammation drugs. This study was conducted to determine the effectiveness of affordable adjuvant therapy, Eucalyptus oil, which has been used as a household remedy for respiratory tract infections in Indonesia.
Methods: 52 mild-moderate COVID-19 patients were randomly assigned for a prospective clinical trial. A group of 26 patients was given standard COVID-19 treatment as a control group, while another 26 patients as the treated group were given standard therapy and use Eucalyptus oil as an adjuvant. The clinical sign and symptoms, cytokines interleukin (IL) 6, IL-10, and transforming growth factor-beta (TGF-β) profiles were recorded during the study period.
Result: There was a trend of better improvement of clinical symptoms among patients who received adjuvant treatment than the control group. Altered smell (p = 0.003) and cough (p = 0.641) recovered faster in the treated group. While there was no marked difference in IL-10 and TGF-β levels among both groups, IL-6 level in the treated group was significantly lower and the neutrophil-to-lymphocyte ratio (NLR) was significantly decreased (p < .05) than the control.
Conclusion: Using Eucalyptus oil as an adjuvant of COVID-19 treatment promotes faster recovery of mild-moderate COVID-19 patients, probably via inhibition of the IL-6-mediated inflammation process.
Umbilical cord-derived mesenchymal stem cell for reducing neointimal hyperplasia: a literature review – exploring possible therapeutic use on arteriovenous fistula patient
Authors: Habibie Yopie Afriandi , Emril Dessy Rakhmawati , Azharuddin  , Syahrizal Dedy 
Published: May 2024

Link of Video Abstract: https://youtu.be/2uoN5ciMk14

Umbilical cord mesenchymal stem cells have been shown to reduce neointimal hyperplasia in animal models. However, current studies about therapeutic use to reduce neointimal hyperplasia mainly utilized bone-marrow and adipose tissue-derived mesenchymal stem cells and lack of in vivo testing from umbilical cord mesenchymal stem cells. Herein, we explore the potential of the therapeutic use of umbilical cord-derived mesenchymal stem cells to reduce neointimal hyperplasia in patients with arteriovenous fistula. Studies were identified from Scopus, Pubmed, and Google Scholar published between 2000 and 2022. The inclusion criteria for the articles were: (1) written in English, (2) focused on the use of mesenchymal stem cells (MSCs) for the treatment of neointimal hyperplasia, and (3) animal-controlled studies. Exosome-derived from mesenchymal stem cell studies were excluded. A total of 9 articles were included. Overall, the available evidence suggests that UC-MSCs may be a promising therapeutic option for reducing neointimal hyperplasia in arteriovenous fistula (AVF) patients. However, more research is needed to confirm these findings and to determine the optimal dosing and administration for their use in clinical practice. Additionally, further studies are required to fully understand the standardization in isolating and characterizing UC-MSCs and their effects on neointimal hyperplasia.
Chiari Malformation (CM) type III surgical management in infant: a case report
Authors: Baktir Yusuf , Suryaningtyas Wihasto , Parenrengi Muhammad Arifin 
Published: May 2024

Background: Chiari Malformations (CM) is a collection of hindbrain abnormalities ranging from simple to complete agenesis of the cerebellum. Type III CM (CM III) is the rarest CM, with herniation of the cerebellum and brainstem into a posterior encephalocele and other intracranial anomalies. Reduction of the viable herniated brain, along with providing intracranial space and inadequate closure, often presents as the main problem. This case study aims to evaluate the Chiari malformation type III surgical management in infants.
Case Presentation: A 16-day-old male infant with an intact congenital mass in the occipital, with no neurological deficit. Radiological examination shows a defect in the occipital skull consisting of cystic non-contrast enhancing lesion and parenchymal tissue herniated through the defect. The cele excision and defect closure were performed, and viable neural tissue was found inside the sac. Blossom flower-like trim expanded the fossa posterior space and put the viable neural tissue inside the intracranial room. The defect was then closed with a dura, periosteal patch, and tension-free two-layered scalp closure. Post-operative follow-up presented a good outcome, and 1-year follow-up showed good recovery, with developmental delay, following developmental rehabilitation.
Conclusion: CM III is rare and has poor outcomes because neurological deficits and respiratory problems usually follow it. Operative management patient with CM III was presented with occipital encephalocele with no post-operative complication. Occipital bone reconstruction using a blossomed-flower-like technique could be considered to create adequate room for viable neural tissue.
Idiopathic giant scrotal calcinosis: a rare case report and literature review
Authors: Wyckmell Octof Ingratoeboen  , Gerhard Reinaldi Situmorang  , Riesye Arisanty  , Madhyra Tri Indraswari  , Ponco Birowo  
Published: May 2024

Link of Video Abstract: https://youtu.be/HwWU4JYsovA

Background: Scrotal calcinosis is a rare abnormality of external genitalia. To date, the pathogenesis of this con is still debated. However, reconstructive surgical therapy is still the treatment of choice in managing this disease. This case report presents our experience in performing extensive excision followed by reconstruction of scrotal defects in patients diagnosed with scrotal calcinosis.
Case Presentation: A 62-year-old healthy man was referred to our department with multiple nodules on the testicular sac that did not cause symptoms but began to disrupt his quality of life. The diagnosis was made by physical examination, and anatomic pathology examination results from a needle biopsy that had been done before. Extensive excision of the scrotum lesion was followed by defect closure. There were no significant intraoperative or postoperative. The procedure was uneventful, and the reconstruction results showed satisfying results.
Conclusion: Scrotal calcinosis is an uncommon skin disease caused by insoluble calcium salts accumulated in scrotal skin tissue. Although the origin and etiology of scrotal calcinosis are debatable, surgical excision is the preferred treatment with a low recurrence rate and good cosmetic results.
The relationship between AQP1 expression in the subventricular zone and severity of hydrocephalus in Rattus Norvegicus strain Sprague-Dawley rats
Authors: Januarman  , Parenrengi Muhammad Arifin , Suryaningtyas Wihasto , Utomo Budi , Bajamal Abdul Hafid , Subagio Eko Agus 
Published: May 2024

Link of Video Abstract: https://youtu.be/pWRyUuqXX7g

Background: Hydrocephalus is a condition of dilation of the ventricles caused by disturbances production, distribution, or absorption of cerebrospinal fluid (CSF). One of the integral membrane proteins identified in facilitating water transport across the plasma membrane is aquaporin-1 (AQP1), which is frequently found in the plexus choroid. However, theoretically also transports water to the subventricular zone (SVZ) with an unknown mechanism. AQP1 expression will be raised in SVZ under hydrocephalus conditions. This study aims to evaluate the relationship between the severity of hydrocephalus and AQP1 levels in SVZ.
Methods: This research was conducted in an experimental design using Rattus Norvegicus rats of the Sprague-Dawley strain, which were injected with kaolin to create a hydrocephalus model. The study included 24 rats, divided into four groups of six each: the control group and the hydrocephalus induction group on day 7, day 14, and day 21. AQP1 expression was observed using immunohistochemical staining and counted semi-quantitatively.
Results: The average AQP1 expression increased with observation time in the rat model in each group. The ANOVA test showed a significant difference between the four study groups (p=0.001). The correlation showed a statistically significant difference (p=0.000). The results showed an increased expression of the SVZ with a higher severity of hydrocephalus.
Conclusion: The severity of hydrocephalus and AQP1 levels in SVZ are correlated, with the latter being higher, the more severe the degree of hydrocephalus.