bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partner Conflict among a Cohort of Women during the Index Pregnancy as measured in the Extended Postpartum Six Weeks Period and its correlates in Ethiopia: Community Based Longitudinal Data; A Multilevel Logistics Regression Analysis
Authors: Damtew Solomon Abrha , Atinafu Niguse Tadele , Gidey Mahari Yihdego , Awoke Tesfamichael 
Published: May 2024

Abstract

Introduction:
Current intimate partner violence (IPV) in Ethiopia is considerably high which pronounced during pregnancy. Recent evidences showed that sexual violence is exceeding physical violence. This study aimed at determining the prevalence of the IPV during the index pregnancy as measured in six weeks postpartum among women in the extended six weeks postpartum period and identify its correlates. Documenting the magnitude of six weeks postpartum IPV during the index pregnancy as measured six weeks in the postpartum period and identifying factors affecting it contributes its share for the ministry and other relevant partners in tracking progress towards eliminating all forms of violence against women and girls by 2030.
Methods
This study used PMA merged cohort 1 baseline and six week postpartum data which enrolled and collected data from currently pregnant women. Frequency was computed to describe the study participant’s characteristics, and chi-square statistics was used to assess cell sample size adequacy. Multilevel binary logistics regression was employed to identify correlates of IPV at the extended six weeks postpartum period. Results were presented in the form percentages and odds ratio with 95% Confidence Intervals. Candidate variables were selected using p-value of 0.25. Statistical significance was declared at p-value of 0.05.
Results
The proportion of experiencing at least one for of physical and/or sexual IPV during the index pregnancy as measured in the extended six weeks postpartum period was 12.14% (10.66%, 13.79%). Over the same period a slightly higher but statistically non-significant 8.09% (6.91%, 9.44%) percentage of women reported that they have experienced at least of form of sexual IPV than the percentage 6.02% (4.94%, 7.31%) of women who reported experiencing at least one form of physical IPV. After controlling confounders, the likelihood of experiencing at least one form of physical and/or sexual IPV during the index pregnancy as measured in the extended six weeks postpartum was 2.14 (1.04, 4.38) times higher among women whose husband had other wife’s compared to those who do not have. On the contrary, women who were residents of Afar region had 86% 0.14 (0.03, 0.79) lower odds of experiencing one form of physical and/or sexual IPV during the index pregnancy as measured in the extended six weeks postpartum. The Ministry of health and developmental partners need to plan and implement Activities and efforts which are specific to regions and that address the problem of polygamy are hoped to address the problem IPV. Such activities should be tailored along the maternal and new born care continuum to be effective.
Spatial transcriptomics uncover coordinated cellular responses to heat stress in developing wheat grains
Authors: WANG JIRUI , Fu Yuxin , Guo Xiaojiang , Cheng MengPing , LI HUIGEN , Liu Zehou , Li Maolian , CHEN QIAN , DONG HUIXUE , YUAN ZHONGWEI , Jiang Qiantao , Chen Guoyue , Qi Pengfei , Pu Zhien , Li Wei , Li Jun , Wei Yuming , Zheng Youliang , Liu Dengcai , Wu Yongrui , Wang Wenqin , Yang Wuyun 
Published: May 2024

Abstract

The grain-filling stage is highly sensitive to heat, impacting wheat yield and quality. This study uncovered Chuanmai104's grain spatial transcriptome atlas under heat stress, identifying over 120 specifically expressed genes crucial for cell sorting and subsequent spatial sequencing across twelve cell types. The cell differentiation trajectory of endosperm indicated high expression of genes for cell development and programmed cell death at early stages, and the subsequent expressed genes enable grains accumulate nutrients. At 15 DAP, recovery grains under heat stress showed significant gene expression changes, especially in the nucellar projection, endosperm near the scutellum, and embryo. Heat stress reduced starch and ABA synthesis gene expression, shortening grain-filling time, reducing grain weight by 28.9%, and raising germination rates from 7.9% to 52.0%. Spatial transcriptomics revealed unexpected shifts in the major expression domains for 189 genes due to heat stress, featuring three major spatial shifts: AL-SCU, ENC-PR, and EXC-NP.
Effective xanthine oxidase inhibitor urate lowering therapy in gout is linked to an emergent serum protein interactome of complement activation and inflammation modulators
Authors: Sanchez Concepcion , Campeau Anaamika , Liu-Bryan Ru , Mikuls Ted R , O'Dell James R , Gonzalez David J , Terkeltaub Robert 
Published: May 2024

Abstract

Background
Urate-lowering treatment (ULT) to target with xanthine oxidase inhibitors (XOIs) paradoxically causes early increase in gouty arthritis flares. Because delayed reduction in flare burden is mechanistically unclear, we tested for ULT inflammation responsiveness markers.
Methods
Unbiased proteomics analyzed blood samples (baseline, 48 weeks ULT) in two, independent ULT out trial cohorts (n = 19, n = 30). STRING-db and multivariate analyses supplemented determinations of altered proteins via Wilcoxon matched pairs signed rank testing in XOI ULT responders. Mechanistic studies characterized proteomes of cultured XOI-treated murine bone marrow macrophages (BMDMs).
Results
At 48 weeks ULT, serum urate normalized in all gout patients, and flares declined, with significantly altered proteins (p < 0.05) in clustering and proteome networks in sera and peripheral blood mononuclear cells. Serum proteome changes included decreased complement C8 heterotrimer C8A and C8G chains and chemokine PPBP/CXCL7, and increased urate crystal phagocytosis inhibitor sCD44. In both cohorts, a treatment-emergent serum interactome included key gouty inflammation mediators (C5, IL-1B, CXCL8, IL6). Last, febuxostat inhibited complement activation pathway proteins in cultured BMDMs.
Conclusions
Reduced gout flares are kinked with a XOI-treatment emergent complement- and inflammation-regulatory serum protein interactome. Serum and leukocyte proteomes could help identify onset of anti-inflammatory responsiveness to ULT in gout.
Trial Registration
ClinicalTrials.gov Identifier: NCT02579096, posted October 19, 2015
Development of a nomogram to predict recurrence scores obtained using Oncotype DX in Japanese patients with breast cancer
Authors: SHIBATA AKIO , Tamura Nobuko , Kinowaki Keiichi , Nishikawa Aya , Tanaka Kiyo , Kobayashi Yoko , Ogura Takuya , Tanabe Yuko , Kawabata Hidetaka 
Published: May 2024

Abstract

Background Chemotherapy is crucial for hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, and its survival benefit may outweigh adverse events. Oncotype DX (ODX) assesses this balance; however, it is expensive. Using nomograms to identify cases requiring ODX may be economically beneficial. We aimed to identify clinicopathological variables that correlated with the recurrence score (RS) and develop a nomogram that predicted the RS.
Methods We included 457 patients with estrogen receptor-positive, HER2-negative breast cancer with metastases in less than four axillary lymph nodes who underwent surgery and ODX at our hospital between 2007 and 2023. We developed nomograms and internally validated them in 310 patients who underwent surgery between 2007 and 2021 and validated the model’s performance in 147 patients who underwent surgery between 2022 and 2023.
Results Logistic regression analysis revealed that progesterone receptor (PgR) level, histological grade (HG), and Ki67 index independently predicted the RS. A nomogram was developed using these variables to predict the RS (area under the curve [AUC], 0.870; 95% confidence interval [CI], 0.82–0.92). The nomogram was applied to the model validation group (AUC, 0.877; 95% CI, 0.80–0.95). When the sensitivity of the nomogram was 90%, the model was able to identify 52.3% low-RS and 41.2% high-RS cases not requiring ODX.
Conclusions This was the first nomogram model developed based on data from a cohort of Japanese women. It may help determine the indications for ODX and the use of nomogram to identify cases requiring ODX may be economically beneficial.
OsPPR8-1 is essential for early chloroplast development at 30 ℃
Authors: Chen Luo , Li Xuezhong , Han Mingzhen , Liu Qingjian , Xie Guowei , Nie Shuai , Ma Yamei , Wang Jian , Yang Wu , Zhou Lian , Li Wenhui , Chen Jiansong , Zhao Junliang , Zhou Lingyan , Dong Jingfang 
Published: May 2024

Abstract

Pentatricopeptide repeat (PPR) proteins regulate the expression of organelle genes in plants by participating in RNA metabolism. In this study, we identified a PPR gene OsPPR8-1 which encodes a typical P subfamily PPR protein with 9 PPR motifs. Compared to dicots, the OsPPR8-1 has a more closer relationship with monocots, such as brachypodium, sorghum, maize, and so on. Expression specificity analysis shows that OsPPR8-1 is highly expressed in green tissues and OsPPR8-1 was localized in chloroplasts. Phenotypic observation revealed that when the OsPPR8-1 gene undergone heterozygous mutations or lacking the one hundred and third (103rd) and one hundred and fourth (104th) amino acids, no significant phenotypic changes were observed. However, when the homozygous deletion of 1 bp, 2 bps or 38 bps in the CDS region of OsPPR8-1 which caused frameshift mutations, the rice seedlings show an albino phenotype from germination to the third-leaf stage, and then gradually died at 30 ℃. All chlorophyll a (Chla), chlorophyll b (Chlb), carotenoid (Car) and total chlorophyll (Chl) significantly decreased in osppr8-1 homozygous mutants, and ultrathin section shows that OsPPR8-1 participates in regulating the generation of chloroplasts. Loss-of-function of OsPPR8-1 resulted in severe defects in the intron splicing of PetB, atpF, trnG and rps12. These results indicate that OsPPR8-1 is indispensable for early chloroplast development and seedling growth in rice by influencing the intron splicing of multiple chloroplast group II introns at 30 ℃.
WITHDRAWN: Lab-on-paper platform for disposable molecular testing with USB-powered isothermal amplification and fluidic control
Authors: Kim Hyun Pyo , Park Ji-Ho , Seok Youngung , Kim Min-Gon 
Published: May 2024

Abstract

The global healthcare market increasingly demands affordable molecular diagnostics for field testing. We introduce a Lab-on-paper (LOP) platform, integrating isothermal amplification with a specially designed paper strip for molecular testing through automated microfluidics process, to meet these unmet needs in point-of-care testing technology. The LOP system has been designed for rapid, cost-effective, and highly sensitive detection, using USB-powered thermal management with a wax valve mechanism. It provides an accessible solution for rapid and accurate detection of various microorganisms, proving particularly beneficial for point-of-care testing in resource-limited environments. Experiments in this study have demonstrated efficacy of the LOP platform in colorimetric detection of foodborne pathogens in spiked samples, identifying Vibrio vulnificus in oysters and Salmonella typhimurium in meat at as few as 60 and 120 CFU per reaction respectively. Portability, ease of use, and affordability of the LOP make it a promising alternative for diverse diagnostic needs, including infectious disease monitoring and ensuring food safety.
Undergarment Needs and Challenges for Breast Cancer Survivors: A Qualitative Study
Authors: Liu Yen-Tung , Khan Novera H. , Nicklaus Krista M. , Moix Marie Karen Bravo , Liu Chi , Reece Gregory P. , Francis Ashleigh M. , Roubaud Margaret J. , Markey Mia K. 
Published: May 2024

Abstract

Purpose
Breast cancer surgery, even with reconstruction, can make it difficult for patients to find a bra that fits properly, is comfortable, and meets their aesthetic standards. We explored breast cancer survivors’ experiences with bras over time to identify preferences, needs, and challenges throughout their journeys.
Methods
Fifteen women who had undergone mastectomy and either delayed or immediate breast reconstruction participated in the study. Focus groups were conducted to explore the participants’ current experiences with bras. They were also prompted to recall their experiences before mastectomy and immediately after reconstruction. The discussion included bra materials, styles, construction techniques, color, quality, and price.
Results
Thematic analysis generated five major themes: “Sense of normalcy and personal well-being,” “Struggles immediately following surgery,” “Transitions in bra experiences and preference,” “Practicality with outfit,” and “Association between quality and price”.
Conclusion
Breast cancer survivors' well-being is linked to their experiences with bras and the associated purchasing process, and bra needs change throughout the cancer care journey. Survivors’ experiences with bras impact their sense of normalcy and sense of control over significant bodily changes arising from cancer and its treatment. The study underscores the importance of future research on examining the relationship between survivors' quality of life and garment experiences, including factors such as color choices, closure options, and adjustability for individual needs.
Revelation method of unmeasured phenomena in Wheeler's "Delayed-Choice" Double-Slit Experiment
Authors: Liu XinHua , Liu ChuangRui , Liu HanRui 
Published: May 2024

Abstract

Wheeler proposed the "Delayed-Choice" Double-Slit Experiment. Some scholars believe that the quantum delayed eraser experiments reveals Wheeler's unmeasurable phenomenon. However, all quantum delayed eraser experiments involve non-locality between entangled photon pairs, causing the timing relationship between events on the idler path and events on the signal path to not necessarily represent the timing relationship between the correspond events on the signal path. In the quantum delayed eraser experiments, the time distinguishing the path passing through the double-slit on the signal path is when they pass through the slits. Therefore, the quantum delayed eraser experimentsdoes not adhere to the condition in Wheeler's "Delayed-Choice" Double-Slit Experiment, which need the distinction of the photons passing through the double-slit is done after the formation of the fringe pattern. The results of the quantum delayed eraser experimentsdo not exhibit the unmeasured phenomenon of Wheeler's "Delayed-Choice" Double-Slit Experiment.This paper proposes a method that eliminates the non-locality effects of entangled photons without using entangled photon pairs. By dividing the route of photons passing through the double-slit into two routes and verifying the fringe pattern based on the number of photons on the two routes, Wheeler's notion of an unmeasured phenomenon becomes measurable, thus providing a revelation method of the unmeasured phenomenon in Wheeler's "Delayed-Choice" Double-Slit Experiment.
Investigation of Cortical Activity during Online Motor Control in Children with Developmental Coordination Disorder: A Functional Near-Infrared Spectroscopy Study
Authors: Huang Quting , Yeung Michael , Fong Kenneth , Chien Chi-Wen 
Published: May 2024

Abstract

Background:
Children with developmental coordination disorder (DCD) have impaired online motor control. Researchers posit that this impairment could be due to a deficit in unitizing the internal model for motor control. However, there is little neurological evidence to support this view because few neuroimaging studies have focused specifically on tasks involving online motor control. Therefore, the aim of this study was to investigate brain activation during an online movement adjustment task in children with DCD.
Methods:
Twenty children with DCD and twenty age-and-gender matched children with typical development were recruited via convenience sampling. Participants performed reaching movement under two conditions (with and without online adjustment of reaching). Children’s cortical activity during movement was recorded using functional near-infrared spectroscopy.
Results:
Outcome showed that children with DCD required significantly more time to correct their reaching movements compared to the control group (t = 3.948, p < 0.001). Furthermore, they exhibited a significantly lower increase in the change in oxygenated hemoglobin concentration (ΔHbO) in the left superior parietal cortex during movement correction (F = 4.482, p = 0.041). Additionally, a significant negative correlation (r = -0.598, P < 0.001) was observed between the difference in movement time of reaching and the difference in ΔHbO between conditions in the left superior parietal cortex.
Conclusions:
Given the function of the superior parietal cortex, it is supposed that deficiencies in processing real-time sensory feedback during the internal model control process could be a crucial factor contributing to the impaired online motor control of DCD. Further intervention may address this issue to enhance DCD’s online motor control.
Contezolid Use for Treating Vancomycin-Resistant Enterococcus Biliary Tract Infections in a Centenarian Patient: A Case Report
Authors: Lv Pu , Liu Lu , Chen Xin 
Published: May 2024

Abstract

In this case, contezolid was successfully used to treat a centenarian male patient with a Vancomycin-resistant Enterococci induced biliary tract infection. Treatment was initiated with contezolid 800 mg every 12 hours for 14 days instead of linezolid due to a significant decrease in platelet count. After treatment, the patient's temperature normalized, the infection was effectively controlled, and organ function improved. There were no reports of infection recurrence or drug-related adverse reactions during a three-month follow-up period. This experience demonstrates the effectiveness and safety of contezolid in managing biliary tract infections.
The Role of Ultrasonography in Monitoring Chemotherapeutic Effects for Primary Thyroid Lymphoma: A Single-center Retrospective Study
Authors: Liu Shi-rong , Fu Ying , Cui Li-gang , Wang Shu-min , Tan Shi 
Published: May 2024

Abstract

Background: This study aimed to assess the utility of ultrasonography in monitoring the chemotherapeutic effects in primary thyroid lymphoma (PTL).
Methods: This retrospective analysis included 17 patients with PTL who underwent chemotherapy from 2012–2022 (>10 years). Sonographic features were examined pre- and post-treatment using ultrasound to monitor treatment response at 2, 4, and end cycles of chemotherapy along with follow-up. Progression-free survival (PFS) and overall survival (OS) were analyzed.
Results: Sonographic findings in all patients indicated diffuse or nodular infiltration with markedly hypoechoic masses. “Strip-shaped” high echoes and posterior acoustic enhancement were observed. In the diffuse group, complete response (CR) rates were 0%, 80%, and 80%, while partial response (PR) rates were 100%, 20%, and 0% at 2, 4, and end cycles post-chemotherapy, respectively. For the nodular group, CR rates were 0%, 20%, and 66.7%, with PR rates of 86.7%, 53.3%, and 13.3% at the same corresponding time points. After the end cycle of chemotherapy, the lesion sizes had significantly decreased compared to baseline (p <0.05). Post-chemotherapy, Adler’s blood flow grades decreased significantly, with 80% graded as 0–1. Among the 10 patients with cervical lymph node enlargement, 70% showed reduced lesion sizes and blood flow signals. The cumulative 5-year PFS and OS rates were 80% and 80% for the diffuse type, and 82.5% and 78.8% for the nodular type, respectively (p >0.05).
Conclusions: Ultrasound examination can be used to monitor PTL treatment response post-chemotherapy, especially for efficacy evaluation after 2 cycles.
Trial registration: retrospectively registered
Comprehensive genetic analysis by targeted sequencing identifies risk factors and predicts patient outcome in Mantle Cell Lymphoma: results from the EU-MCL network trials
Authors: Pott Christiane , Khouja Mouhamad , Jiang Linmiao , Pal Karol , Stewart James , Regmi Binaya , Schwarz Martin , Klapper Wolfram , Alig Stefan , Darzentas Nikos , Kluin-Nelemans Hanneke , Hermine Olivier , Dreyling Martin , Gonzalez David , Hoster Eva 
Published: May 2024

Abstract

Recent studies highlighted genetic aberrations associated with prognosis in Mantle Cell lymphoma (MCL), yet, comprehensive testing is not implemented in clinical routine. We conducted a comprehensive genomic characterization of 180 patients from European MCL network trials by targeted sequencing of peripheral blood DNA using the EuroClonality(EC)-NDC assay. The IGH::CCND1 fusion was identified in 94% of patients, clonal IGH-V-(D)-J rearrangements in all, while 79% had ≥ 1 somatic gene mutation. The top mutated genes were ATM, TP53, KMT2D, SAMHD1, BIRC3 and NFKBIE. Copy number variations (CNVs) were detected in 83% of patients with RB1, ATM, CDKN2A/B and TP53 being the most deleted and KLF2, CXCR4, CCND1, MAP2K1 and MYC the top amplified genes. CNVs and mutations were more frequently observed in older patients with adverse impact on prognosis. TP53mut, NOTCH1mut, FAT1mut TRAF2del, CDKN2A/Bdel and MAP2K1amp associated with inferior failure-free and overall survival (OS), while TRAF2mut, EGR2del and BCL2amp associated with inferior OS only. Genetic complexity (≥ 3 CNVs) observed in 51% of analysed patients associated significantly with impaired FFS and OS. We demonstrate that targeted sequencing from peripheral blood and bone marrow detects diagnostically and prognostically important genetic factors of MCL in patients treated in prospective trials, facilitating genetic characterization in clinical routine.
Don’t Wait, Vaccinate: Evaluation of Routine Immunization Administration and Reactogenecity in Preterm Infants
Authors: Bashqoy Ferras , Abdelmessih Emily , Desai Purnahamsi , Tracy Joanna , Papadopoulos John 
Published: May 2024

Abstract

Objective: To evaluate the incidence of cardiorespiratory events in preterm infants when administering the 2-month vaccine series all at once compared to spreading vaccines over multiple days.
Study Design: This single-center, retrospective cohort study from 2019-2022 included preterm neonates receiving 2-month immunizations. The primary outcome was incidence of cardiorespiratory events from time of initial vaccine administration up to 48 hours after final administration. Univariate analysis performed to identify predictors of primary outcome.
Results: There were 127 patients (n1=52, n2=75) included. There was no difference in the number of cardiorespiratory events between groups. Predictors of severe event included younger gestational age, smaller birth weight, smaller birth length, and higher baseline apnea or bradycardia events at baseline. Vaccine schedule interruptions occur more often when administration is spread over multiple days.
Conclusion: Administration of routine 2-month vaccinations all at once was not associated with increased cardiorespiratory events and prevents interruptions to vaccine schedule.