bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of CAD/CAM Technology in Fabricating Custom Post‐and‐Core Restorations: A Comparative Analysis
Authors: Mourouzis Petros , Dionysopoulos Dimitrios , Tolidis Kosmas 
Published: February 2025

ABSTRACTObjectiveThis study aims to compare the accuracy of various intraoral scanners and traditional analog impressions in scanning root canals for CAD/CAM post‐fabrication.MethodsA dental mannequin with a factory‐made #21 tooth root canal was used to simulate clinical settings. Three intraoral scanners were tested: CEREC Primescan, TRIOS 3, and CEREC Omnicam. The inEos X5 desktop scanner provided high‐resolution control images. The analog impression polyvinyl siloxane (PVS) material was used with custom trays, following standard protocols. The surface areas were measured with CAD software and compared with the desktop scanner's reference.ResultsPrimescan demonstrated the highest accuracy among the intraoral scanners, followed by Trios 3 and Omnicam. Significant differences were found between each scanner and the true surface area. The analog impression method demonstrated superior accuracy compared with intraoral scanners; however, this high precision is attributed to irregularities in the silicone material.ConclusionsThe analog impression method was more accurate in capturing the details of complex root canal anatomy; however, material irregularities can affect its clinical efficacy. Intraoral scanners showed high accuracy but had some limitations in capturing complex geometries. Further development of scanner technology will increase precision and, therefore, the clinical outcome.Clinical SignificanceThe use of CAD/CAM technology and intraoral scanners offers potential for precise, custom‐fit post‐and‐core restorations.
Ultra‐Processed Foods and Dietetic Practice: Findings From a Survey and Focus Group With UK Dietitians
Authors: Moran Veronica , Moore Sally G. , Ho Peter 
Published: February 2025

ABSTRACTBackgroundFood processing converts fresh food into products and is of interest to nutrition professionals including dietitians given emerging evidence linking consumption of 'ultra‐processed' products with health.ObjectiveTo explore dietitians' professional practice around the topic of processed foods and health, including their perceptions of individual food products.MethodsAn online survey was developed to evaluate professional involvement, confidence and views using a 5‐point scale (i.e., 1 = never, 5 = daily). Respondents' perceptions of three products were also obtained, including level of processing (LoP) (from 1 = unprocessed to 5 = ultra‐processed) and recommended frequency of consumption (FoC) (from 1 = avoid to 5 = several times/day). Eligible survey respondents (UK dietitians) were recruited via the British Dietetic Association and social media. Data were analysed descriptively. A focus group was held with five dietitians to discuss current practice around this topic. Verbal data were thematically analysed.ResultsSurvey respondents (n = 366) possessed an average of 13 ± 9.8 years practising across various specialisms. Most discussed (82%) and provided guidance on (77%) processed foods and health monthly or more frequently, with 'high' levels of confidence (61%–59%), and agreed that healthy diets may include processed (94%) or 'highly/ultra' processed (71%) foods. Perceptions of each individual food product varied, yet the largest proportion of respondents selected LoP and FoC options for Tinned tomatoes: 'minimally processed' (54%), 'several times/week' (69%); mycoprotein mince: 'highly/ultra‐processed' (57%), 'several times/month' (40%); and wholemeal bread: 'processed' (46%), 'several times/week' (58%). Focus group themes included uncertainties in definitions of ultra‐processed and negative consumer perceptions around processing.ConclusionThis first survey of UK dietitians on processed foods suggests that dietetic practice frequently involves this topic and that views on the role of these foods in healthy diets are varied. Respondents also possessed a range of perceptions on the LoP of individual products, and further work is now warranted to support future development for dietetic practice.
Ganaxolone Reverses the Effect of Amyloid β‐Induced Neurotoxicity by Regulating the Liver X Receptor Expression in APP Transfected SH‐SY5Y Cells and Murine Model of Alzheimer's Disease
Authors: Divya  , Faruq Mohammed , Nazir Sheikh Sana , Kaushik Pooja , Parvez Suhel , Vohora Divya 
Published: February 2025

ABSTRACTInhibiting β‐amyloid aggregation and enhancing its clearance are the key strategies in Alzheimer's disease (AD) treatment. Liver X receptors (LXRs) plays a crucial role in cholesterol homeostasis and inflammation, and their activation can clear Aβ aggregates in AD. Allopregnanolone, a neurosteroid, positively influences AD through LXR regulation, while ganaxolone, its synthetic analog, is known for its neuroprotective properties. This study explores the effect of ganaxolone on LXR activation and regulation of genes involved in mitigating Aβ toxicity and tauopathy in SH‐SY5Y cells transfected with APP695 Swe/Ind plasmid and an Aβ1–42 induced AD mouse model. Molecular docking stimulations indicated ganaxolone's binding and interaction with LXRβ. Subsequently, transfected neuronal cells exhibited increased mRNA levels of APP, TNF‐α and IL‐1β, decreased cell viability, reduced MMP and altered protein expression of Aβ, LXR, BCL‐2, APOE, ABCA1, along with increased levels of mROS, Bax, and caspase 3 activity. Ganaxolone treatment significantly abrogated Aβ‐induced effect in transfected neuronal cells by enhancing LXRβ expression, inducing LXR:RXR colocalization, thereby increasing APOE and ABCA1 expression. It also decreased tau mRNA levels in transfected cells. Importantly, in AD mice, ganaxolone ameliorated cognitive impairment, reduced Aβ toxicity, tau levels, and neuroinflammatory markers, restored mitochondrial function, and decreased neuronal apoptosis. Taken together, these novel results highlight the central role of LXR in mediating Aβ‐induced toxicity and provide preclinical evidence for ganaxolone as a potential agent to reduce toxicity in an LXR‐dependent manner. This may serve as a promising treatment strategy to slow or prevent neurodegeneration in AD patients.image
Climate Change Adaptation: New Vistas for Management Research
Authors: Benischke Mirko H. , D'Ippolito Beatrice , Sharma Garima , Wickert Christopher 
Published: February 2025

AbstractClimate change adaptation has for a long time been the neglected half of the climate equation, as most attention has been directed toward mitigation. Yet, the catastrophic effects of a changing climate are already occurring, unavoidable, and in many cases irreversible. Organizations need to identify ways of adapting to present and future climatic conditions. In this editorial, we make the case for climate change adaptation as a research topic on par with mitigation. We outline how and why management and organizational scholarship should work toward an integrated approach of mitigation and adaptation in responding to climate change, suggesting three key avenues of research for future inquiry. In so doing, we encourage more impactful and ecologically relevant management research that will make a difference to society at large.
A Study of Body Composition in Children Suffering From Infantile Vitamin B12 Deficiency
Authors: Vohra Viresh , Kaur Harvinder , Attri Savita Verma , Bharati Bhavneet , Kumar Pawan , Kesavan Shivan , Sankhyan Naveen 
Published: February 2025

ABSTRACTBackgroundInfantile tremor syndrome (ITS), or neurocutaneous infantile vitamin B12 deficiency syndrome (NIBS), is characterised by tremors, developmental delay, anaemia and skin hyperpigmentation. This study aimed to assess the body composition and serum lipids in children with ITS.MethodsChildren under 2 years of age with a clinical diagnosis of ITS were enrolled. Dietary history, developmental milestones and anthropometric data were recorded, along with blood tests for B12, homocysteine, lipid profile and blood counts.ResultsOf 50 children screened, 31 with a median age of 13 months were included. Most (80.6%) were from lower socio‐economic backgrounds. Limb tremors were observed in 51.6%, and all but one child had a developmental quotient (DQ) below 70, indicating significant developmental delays. Microcephaly was present in 35.4%, and moderate to severe anaemia was nearly universal. Growth parameters, including fat mass and fat‐free mass, were significantly lower in children with ITS compared to controls. Lipid profiles revealed consistently high triglycerides, low HDL and elevated LDL in most age groups, suggesting a pro‐atherogenic metabolic state.ConclusionSevere Infantile vitamin B12 deficiency significantly impairs head growth, overall development and body composition, with potential long‐term cardiovascular risks due to abnormal lipid profiles.
A Bottleneck Analysis of Iron and Folic Acid Supplementation Program in Pakistan
Authors: Ghur Anamta , Randhawa Soha , Shahid Namira , Ali Waffa , Ali Banafsha , Rashid Saroosh , Khan Ambreen , Babri Aman Akbar , Masood Khawaja , Shuja Saba , Fatima Maliha , Ali Noshad , Khan M. Imran , Turab Ali 
Published: February 2025

ABSTRACTIron and folic acid deficiency is a significant public health concern, especially in low and middle‐income countries, particularly among women of reproductive age, leading to adverse maternal and child health outcomes. In Pakistan, approximately 41.7% of women of reproductive age have iron deficiency. For this research, we conducted 33 key informant interviews and 32 focus group discussions with stakeholders from all four provinces and the two federally administered regions of Pakistan for in‐depth and representative bottleneck assessment. The modified Tanahashi model was used to inform the determinant codes and for coding reliability thematic analysis using NVivo 14. On the supply side, barriers relate to effective forecasting, procurement, and distribution of Iron Folic Acid supplements to the recipients. The demand–supply gap widened due to the supply bottlenecks, impacting the community's trust in the frontline health worker. These factors were gravely impacted by the governance challenges of ensuring sustainable funds, minimizing bureaucratic and procedural delays, and eliminating political pressure. Affordability of Iron Folic Acid and conservative social norms influenced the demand and awareness of Iron Folic Acid and nutritional knowledge among the target population. The stakeholder recommendations emphasize the need for intersectoral collaboration, mass media campaigns, frequent capacity building and incentivizing of healthcare workers, engagement of key community stakeholders, digitizing the health system, improvement in supply chain mechanism, and investment in small‐scale innovative solutions.
Epigenomic Changes in Ostrinia Moths Under Elevated Pupal and Adult Temperature
Authors: Velikaneye Brittany A. , Kozak Genevieve M. 
Published: February 2025

ABSTRACTEpigenetic changes in the methylation of DNA may occur in response to environmental stressors, including warming climates. DNA methylation may also play an important role in regulating gene expression during both male and female reproduction in many insect species. However, it is currently unknown how DNA methylation shifts when individuals are reproducing under warmer temperatures. We exposed European corn borer moths (Ostrinia nubilalis) to heat during the pupal and adult life stages then investigated changes in DNA methylation across the genome using enzymatic methyl‐seq (EM‐seq). We compared methylation patterns in reproductive males and females exposed to heat (28°C) to those that experienced an ambient temperature (23°C). We found that heat exposure led to a small but significant increase in the percentage of methylated CpG sites throughout the genome in both sexes. However, DNA methylation rates were higher in females and differential methylation following heat exposure localised to unique regions in each sex. In males, methylation shifted within genes belonging to pathways including Hippo signalling, ubiquitin‐mediated proteolysis, DNA damage repair and spermatogenesis. In females, differential methylation occurred in genes related to histone modification and oogenesis. Our results suggest that DNA methylation patterns respond to moderate heat exposure in Lepidoptera and provide insight into epigenetic responses to heatwaves, suggesting novel pathways that may be involved in responding to heat stress during metamorphosis and reproduction.
REIMAGINE: A central nervous system basket trial showing safety and efficacy of vafidemstat on aggression in different psychiatric disorders
Authors: Ferrer Marc , Richarte Vanesa , Gisbert Laura , Xaus Jordi , Gutierrez Sonia , Arevalo Maria Isabel , Ropacki Michael , Bullock Roger , Buesa Carlos , Ramos‐Quiroga Josep Antoni 
Published: February 2025

AimVafidemstat is a brain‐penetrant, orally bioavailable, small molecule irreversible inhibitor of the histone lysine‐specific demethylase KDM1A (also known as LSD1), which corrects memory deficits and behavior alterations including aggression and social interaction deficits in preclinical models.MethodsHere, we report the results of REIMAGINE, a phase IIa, single‐center, open‐label, one‐arm basket trial that evaluated the safety and efficacy of vafidemstat on aggression in adult patients with borderline personality disorder (BPD), attention‐deficit/hyperactivity disorder (ADHD), and autistic spectrum disorder (ASD). Participants received 1.2 mg/day of vafidemstat for 8 weeks.ResultsVafidemstat was shown to be safe and well tolerated, and no drug‐related clinically significant adverse events were observed. Furthermore, all neuropsychiatric scales assessed showed notable efficacy signals, whether assessing agitation/aggression (Clinical Global Impression for Severity [CGI‐S] and Clinical Global Impression for Improvement [CGI‐I] and Neuropsychiatric Inventory [NPI] questionnaire for Agitation‐Aggression [NPI‐AA]), overall patient functioning (total NPI), or disease‐specific features (Attention‐Deficit/Hyperactivity Disorder Rating Scale [ADHD‐RS] and Borderline Personality Disorder Checklist [BPDCL]). Statistically significant improvements were observed in the aggregated data (all participants) and for each of the three disease groups independently. Changes were evident within the first 2 weeks of treatment.ConclusionIn summary, the REIMAGINE study supports that vafidemstat is safe, well tolerated, and causes a significant and consistent reduction in agitation/aggression and nonaggression features in BPD, ADHD, and ASD. These data support continuing the development of vafidemstat as a new treatment option for these psychiatric disorders.
Evaluation of NANOG/HDAC1 Expression in Predicting Outcomes of BCG Therapy in Non‐Muscle Invasive Bladder Cancer
Authors: Yamashita Takahisa , Higashi Morihiro , Yamazaki Mami , Imada Hiroki , Takayanagi Natsuko , Shimizu Tomomi , Sawada Keisuke , Yamamoto Wataru , Murakami Chiaki , Nagata Marino , Kikuchi Yukina , Momose Shuji 
Published: February 2025

ABSTRACTUrinary bladder cancer includes non‐muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC). While patients with NMIBC have a better prognosis, NMIBC often recurs, requiring long‐term surveillance and repeated treatments. Intravesical Bacillus Calmette‐Guérin (BCG) therapy is standard for high‐grade or recurrent NMIBC; however, 30%–50% of patients failed to respond, and the mechanisms of resistance remain unclear. To identify predictive biomarkers for response to intravesical BCG therapy, we analyzed NANOG and Histone deacetylase 1 (HDAC1) expression in 90 bladder cancer specimens from NMIBC patients treated with BCG therapy using immunohistochemistry. The correlation between NANOG and HDAC1 expression and clinical outcomes, including response to BCG therapy, was assessed. High‐grade NMIBC cases showed significantly higher expression of NANOG and HDAC1 compared to low‐grade cases (p < 0.05). Additionally, elevated NANOG expression in combination with HDAC1, was associated with poor response to BCG therapy and decreased lymphocyte infiltration in the tumor‐microenvironment. NANOG is suggested to directly increases HDAC1 expression, which could suppress lymphocyte infiltration in the tumor microenvironment by altering immune‐related gene expression. These findings suggest that the NANOG/HDAC1 axis plays a key role in predicting resistance to intravesical BCG therapy in NMIBC.
Substitutability evaluation and resource utilization of non‐medicinal parts of Ardisia crenata Sims, a traditional ethnic medicine
Authors: Peng Jie , Liu Sha , Liu Fusong , Qin Lin , Wang Qian , He Yuqi , Zhang Delin , He Wenping , Ke Xinyue , Wu Faming , Wang Xiaoshuang 
Published: February 2025

AbstractThe severe scarcity of wild resources of Ardisia crenata Sims (AS) has greatly limited its current clinical and pharmaceutical applications. We aimed to demonstrate the substitutability of stems and leaves for AS roots. In this study, 28 local samples from the Guizhou Province of China were selected for a comprehensive comparison of quality markers, chemical composition and efficacy. HPLC analysis showed that both stems and leaves contained bergenin, the main active ingredient of AS. Metabolomics studies showed that the chemical composition of the three parts was 99% similar. Network pharmacology analysis showed that similar signalling targets including STAT3 and MAPK1, AKT1 and EP300, SRC and TP53, were targeted by three parts. Animal experiments further demonstrated that extracts from the three different parts of the plant relieved the pathological symptoms of acute pharyngitis, and decreased serum inflammatory factors, showing similar efficacy. In sum, these findings strongly proved that stems and leaves can be used as supplements or substitutes for roots, providing a powerful strategy to solve the problem of AS resource shortage and greatly promoting the optimal utilization of AS. The study also anticipated some additional benefits, including the expansion of natural sources of bergenin and the discovery of potential cancer‐related targets of AS.
Financial Inclusion, Digital Technology and Farmers' Well‐Being Nexus: Evidence From Rural of Xizang, China
Authors: Li Fanghua , Chandio Abbas Ali , Zang Dungang , Liu Haiyue 
Published: February 2025

ABSTRACTThe paper examines the impact of financial inclusion on farmers' well‐being and the moderating role of digital technology in this relationship in rural areas of Xizang, China. It relies on transaction cost theory to equate utility with well‐being, using 2021 micro‐survey data from the region to address its objectives. The findings reveal a positive impact of financial inclusion on farmers' well‐being. To examine the moderating role of digital technology, the paper explores both internal and external embedding of digital technology. The findings indicate that the impact of external embedding is greater than that of internal embedding. Additionally, the paper provides evidence that financial inclusion significantly improves the well‐being of farmers in poverty‐eradicated and non‐elite rural groups, showing no indication of “favoring the rich over the poor” or “elite capture.” These findings provide new evidence for research on farmers' well‐being in underdeveloped regions.
Asymptotic Behavior of a Degenerate Forest Kinematic Model With a Perturbation
Authors: LI Lu , Cantin Guillaume 
Published: February 2025

ABSTRACTIn this paper, we study the asymptotic behavior of the global solutions to a degenerate forest kinematic model, under the action of a perturbation modeling the impact of climate change. In the case where the main nonlinear term of the model is monotone, we prove that the global solutions converge to a stationary solution, by showing that the Lyapunov function derived from the system satisfies a Łojasiewicz–Simon gradient inequality. We also present an original algorithm, based on the Statistical Model Checking framework, to estimate the probability of convergence toward nonconstant equilibria. Furthermore, under suitable assumptions on the parameters, we prove the continuity of the flow and of the stationary solutions with respect to the perturbation parameter. Then, we succeed in proving the robustness of the weak attractors, by considering a weak topology phase space and establishing the existence of a family of positively invariant regions. At last, we present numerical simulations of the model and explore the behavior of the solutions under the effect of several types of perturbations. We also show that the forest kinematic model can lead to the emergence of chaotic patterns.
Holding It, Together: Beyond Bearing Witness and Burning Out
Authors: Sheese Kate 
Published: February 2025

ABSTRACTConcepts like vicarious trauma, burnout, compassion fatigue, and moral injury do important work in making suffering legible and enabling claims to recognition, acknowledgement, and care. Nonetheless, these conceptualizations have little to say about the nature of the suffering, the varied and ambiguous ways it is experienced, or the social, affective, political conditions that give rise to it. In this article I argue for taking up response‐ability as a lens for examining, understanding, and addressing the particular kinds of suffering experienced when registering and resisting violence, particularly in the face of complicity. Drawing on ethnographic work with activist volunteers in refugee camps, I explore what response‐ability, with its relational ontology, allows us to see, feel, understand about suffering that is otherwise out of view, obscured, or rendered unsayable, or even unfeelable. I discuss the ways in which response‐ability assumes complicity and requires grief/mourning and explore how these characteristics alter the possibilities and obligations for collective care and containment when intervening in crises and conflicts.
Characterisation of the Novel HLA‐DQB1*03:572 Allele by Next‐Generation Sequencing
Authors: Wanyan Zhang‐Xiang , Bian Cheng , Wang Xiao‐Hui , Zheng Zhong‐zheng , Yang Zhao‐Qing 
Published: February 2025

ABSTRACTHLA‐DQB1*03:572 differs from DQB1*03:01:01:01 by one nucleotide substitution at position 208G>T in exon 2.