bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Facial Tactics on Anxiety Levels in Postpartum Mothers
Authors: Dinengsih Sri , Allen Lesta , Kundaryanti Rini 
Published: June 2024

The prevalence of mental disorders such as depression and anxiety disorders in mothers is recorded to have a weighted average of 15.6% during pregnancy and 19.8% after childbirth from around 14 million people from the Indonesian population, mothers experience anxiety after childbirth is recorded as much as 22.4%, anxiety in postpartum mothers that cannot be resolved can cause postpartum depression and other mental disorders that interfere with health. Knowing the effect of facial massage on the anxiety level of postpartum mothers in TPMB P West Jakarta in 2023. The study use quasi experimental type of research with pretest posstest with control two group research design, Taking sample done use technique total sampling amounted to 30 postpartum mother consisting of 15 responden group intervention and 15 responden groups control. The instrument used was Hamilton Rate Scale- measurement questionnaire (HRS-A). data analysis use desriptive statistic and paired T Test to know difference level anxiety before and after intervention. The average value of the level of anxiety before facial massage (18.60) and after facial massage (13.30) and in the control group the results of the average value of the level of anxiety before the positive affirmations (17.27) and after the positive affirmations (16.13) with P-value of 0.000 < 0.05, means ada the effect facial massage on the level of anxiety in postpartum mothers. There is an effect of facial totok on anxiety levels in postpartum women. but facial totok is more significant in reducing anxiety levels than positive affirmations. for adding additional services and new entrepreneurs as complementary midwifery services by adding a facial totok treatment package along with the delivery package to overcome anxiety in postpartum women.
Особливості розвитку компетентностей вчителів початкової школи в умовах методичної роботи закладів загальної середньої освіти
Authors: Митник Олександр 
Published: June 2024

У статті зазначено, що розвиток компетентності вчителів у початковій школі є ключовим аспектом у забезпеченні якісної освіти для молодших школярів. Компетентний вчитель здатний не лише передати знання, але й виховати в учнів критичне мислення, творчі здібності та соціальні навички.
Проаналізовано та визначено форми інформаційних технологій інноваційного методичного супроводу розвитку методичної компетентності учителів початкової школи (колективні та індивідуальні). Проаналізовано нетрадиційні форми науково-методичної роботи, які відповідають завданням підвищення професійної майстерності за умов реформування освітньої галузі.
Встановлено, що процеси модернізації змісту освіти, нові пріоритети освітньої політики, зміна концептуальних орієнтирів стимулює пошук нових підходів до методичної діяльності; розробку системи методичної роботи в умовах інформатизації суспільства; визначення, апробацію та обґрунтування комплексу педагогічних умов підвищення ефективності методичної роботи у сучасних умовах.
Визначено, що широке коло завдань методичної діяльності, характер її постійно обновлюваного змісту, а також рівень компетентності педагогічних кадрів, який також зазнає змін, потребують різноманітних інноваційних форм роботи. У процесі організації методичного супроводу розвитку науково- методичної компетентності вчителів початкової школи ефективними технологіями можуть бути: особистісно-орієнтовані; контрольно-оцінні; кваліметричні; інформаційні.
Зазначено, що творчість в педагогічній роботі багато в чому залежить від тієї психологічної атмосфери, яка склалась у колективі, ставлення адміністрації до творчих педагогів і, безперечно, системи методичної роботи в освітньому закладі; розвиток компетентності вчителів початкової школи є фундаментом для створення якісної та сучасної системи освіти. Тільки через постійне навчання, взаємодію та підтримку можна забезпечити високий рівень викладання, що сприятиме формуванню успішних, творчих та соціально активних громадян.
Доведено, що науково-методична компетентність вчителів початкової школи є ключовим елементом, який забезпечує високу якість освіти, сприяє всебічному розвитку учнів та професійному зростанню педагогів.
Impact of buried versus exposed flexible intramedullary nails osteosynthesis on pediatric forearm fractures
Authors: Dündar Abdulrahim , Kaya Şehmuz 
Published: June 2024

En el uso de clavos intramedulares elásticos estables (ESIN) existen diferentes opiniones entre los cirujanos sobre dejar el clavo introducido en el mismo brazo o bien dejarlo expuesto.Objetivo: Determinar el riesgo de re-fractura en pacientes con clavo intramedular cubierto versus expuesto como tratamiento de las fracturas de antebrazo, e investigar las complicaciones postoperatorias.Pacientes y Método: El estudio incluyó un total de 113 pacientes pediátricos con fractura de ambas diáfisis del antebrazo. Se formaron dos grupos en función del dispositivo introducido en el mismo brazo (Grupo B, n: 53) o dejado al descubierto (Grupo E, n: 60). Se realizaron análisis con respecto al número de reducciones abiertas, el tiempo transcurrido hasta la retirada del implante, el tipo de anestesia utilizado para esta ocasión, el número de refracturas, la infección cutánea y la irritación del lugar de entrada del clavo. Resultados: Los tiempos promedio de fusión entre los grupos no fueron muy diferentes (P = 0,371). El tiempo promedio de retirada del implante en el grupo B (16,02 ± 1,29 sem) fue muy superior en comparación con el del grupo E (6,65 ± 0,95 sem) (P < 0,001). Las tasas de reducción de aperturas fueron similares entre los grupos (P = 0,401). La tasa de anestesia general para la extracción de implantes en el grupo B (77,4%) fue muy superior a la del grupo E (11,7%) (P < 0,001). La tasa de refractura fue mayor en los pacientes sometidos a reducción abierta en ambos grupos (P < 0,001).Conclusión: Los resultados de este estudio demostraron que, a pesar de la mayor tasa de infección, dejar el clavo expuesto no aumentaba la tasa de refractura, que se veía más asociada a la reducción abierta.
Single-colour, visible light activation and excitation of the luminescence of a ‘switch-on’ dye and enhancement by silver nanoparticles
Authors: Trifoi Lavinia A. , Dogantzis Nicholas P. , Hodgson Gregory
K. , Ortiz Pedro D. , Soha Sumaiya A. , Antonescu Costin N. , Botelho Roberto , Wylie R. Stephen , Impellizzeri Stefania 
Published: June 2024

<p>We synthesized a fluorogenic methylated dihydrofluorescein derivative in two convenient steps from commercial <a href="https://www.sciencedirect.com/topics/chemistry/fluorescein" target="_blank">fluorescein</a>. This species can switch to the corresponding oxidized form upon visible-light illumination at an activating wavelength of 455 nm, where the photoinduced transformation culminates in the activation (‘switch on’) of the fluorescence, which can be observed by exciting the photoproduct at the same wavelength of activation. Thus, a single wavelength can be used to simultaneously activate and excite fluorescence. Mechanistic investigations suggest that singlet oxygen does not contribute to the formation of the fluorescent oxidation product. The single-colour activation/excitation mode of this model structure can effectively mimic a pseudo two-colour system and can find broad application in the development of photonic materials operated with simple optical setups. The activated fluorescence can be concomitantly enhanced by triangular silver nanoparticles according to the principles of metal-enhanced fluorescence (MEF).</p>
Periodic Paralysis and the Emergency Department: A Case Series of Thyrotoxicosis Periodic Paralysis with Literature Review
Authors: Ahmed ElKholi  , Haider Ali , Maryam Mahmood Ali  
Published: June 2024

Thyrotoxic periodic paralysis is a rare but serious complication of thyrotoxic. It is an uncommon form of hypokalemic periodic paralysis characterized by proximal muscle weakness that may progress to involve distal muscle and respiratory muscle. Thyrotoxic periodic paralysis is commonly reported among Asian descent; especially the male population, between the ages of 20 and 40 years. The actual pathophysiology of Thyrotoxic periodic paralysis is unclear. However, hyperthyroidism, channelopathies, high-carbohydrate food, and hyperandrogenism are the most common predisposing factors associated with this condition. Hypokalemia and muscle weakness in Thyrotoxicosis patients result from increased shifting of K+ intracellularly. This is known to be related to increased sodium-potassium-a adenosine triphosphatase (Na/K-ATPase) pump number and activity. The proper aim of treatment in Thyrotoxicosis patients is to reach the euthyroid state. Management of Thyrotoxic periodic paralysis at the Emergency department includes establishing Intravenous potassium replacement, starting non-selective beta-blockers to reduce the phosphate and potassium intracellular shifting, and normalizing the underlying hyperthyroid state. Here, we present two cases of Thyrotoxic Periodic Paralysis. These cases reiterate the need to consider all the complications of Thyrotoxicosis, even rare ones, to treat the condition and reverse the effect of periodic hypokalemia within the Emergency Department, to prevent any inevitable complication.
Justicia consensual: una apuesta por lo funcional y los resultados prácticos
Authors: Moreno Rojas Jorge Alberto , Rubiano Medina Alfonso 
Published: June 2024

La ley penal de nuestro país, se caracterizaba por su corte inquisitivo materializado con la Ley 600 (2000), y es con la entrada en vigencia de la Ley 906 (2004) donde este paradigma cambia para hacerla de carácter acusatorio, siguiendo como ejemplo el sistema anglosajón e introduciendo una herramienta novedosa y por algunos cuestionables como lo son los preacuerdos y negociaciones entre el ente acusador y el acusado que busca impactar con un cambio de paradigma que traslada lo jurídico a lo sociológico, humanizando así el proceso penal siendo está acorde con el preámbulo de nuestra constitución, y lo que busca en sí es dar solución rápida y eficaz al proceso, descongestionar los despachos judiciales, garantizar verdad y reparación a la víctima y en cuanto al indiciado asegurar rebaja de la pena o beneficios por su aceptación de cargos.
Outdoor cultivation of Picochlorum sp. in a novel V-shaped photobioreactor on the Caribbean island Bonaire
Authors: Chin-On Rocca , de Boer Mila , van de Voort Cas , Camstra Juliëtte , Barbosa Maria , Wijffels René H. , Janssen Marcel 
Published: June 2024

Microalgae are a promising renewable feedstock that can be produced on non-arable land using seawater. Their biomass contains proteins, lipids, carbohydrates, and pigments, and can be used for various biobased products, such as food, feed, biochemicals, and biofuels. For such applications, the production costs need to be reduced, for example, by improving biomass productivity in photobioreactors. In this study, Picochlorum sp. (BPE23) was cultivated in a prototype of a novel outdoor V-shaped photobioreactor on Bonaire (12°N, 68°W). The novel photobioreactor design was previously proposed for the capture and dilution of sunlight at low-latitude locations. During several months, the biomass productivity of the local thermotolerant microalgae was determined at different dilution rates in continuous dilution and batch dilution experiments, without any form of temperature control. Reactor temperatures increased to 35°C–45°C at midday. In the continuous dilution experiments, high average biomass productivities of 28–31 g m−2 d−1 and photosynthetic efficiencies of 3.5%–4.3% were achieved. In the batch dilution experiments, biomass productivities were lower (17–23 g m−2 d−1), as microalgal cells likely experienced sudden light and temperature stress after daily reactor dilution. Nonetheless, dense cultures were characterized by high maximum photosynthetic rates, illustrating the potential of Picochlorum sp. for fast growth under outdoor conditions.
Association between total cholesterol and all-cause mortality in oldest old: a national longitudinal study
Authors: Hu Fan , Wang Zhiqiang , Liu Yujie , Gao Ying , Liu Shangbin , Xu Chen , Wang Ying , Cai Yong 
Published: June 2024

BackgroundA common sense is that lower serum cholesterol levels are better. However, a growing number of researches have questioned this especially for the oldest old. The current study was to assess the association between total cholesterol and all-cause mortality in a group of people aged 85 years old and over.MethodsWe selected 903 Chinese old participants who aged ≥85 years from the Chinese Longitudinal Healthy Longevity Survey(CLHLS) at baseline in 2012. The participants were followed up until death or until December 31, 2014. The outcome was all-cause mortality. The univariate and multivariate Cox regression analyses were used to estimate risk levels of all-cause mortality. We stratified the participants into three groups (&lt;3.40, 3.40–4.39, ≥4.39 mmol/L) based on the restricted cubic splines methods. The survival probability according to total cholesterol category was calculated using the Kaplan-Meier curves, and the log-rank test was performed to analyze differences between the groups.ResultsDuring the follow-up of three years, 282 participants died, 497 survived and 124 lost to follow-up. There was significant relationship between the total cholesterol and lower risk of all-cause mortality in the multivariable Cox regression analysis (HR=0.88, 95% CI: 0.78–1.00). Based on the restricted cubic splines methods, the total cholesterol was converted from a continuous variable to a categorical variable. The populations were divided into three groups (&lt;3.40, 3.40–4.39, ≥4.39 mmol/L) according to the total cholesterol categorized by cutoff values. Compared to the total cholesterol level of &lt;3.40 mmol/L, populations in the total cholesterol level of 3.40–4.39 mmol/L (HR = 0.72, 95% CI: 0.53–0.97) and ≥4.39 mmol/L (HR = 0.71, 95% CI: 0.52–0.96) groups had lower all-cause mortality in multivariate Cox regression analysis and higher survival probability in survival analysis. When two groups were divided, similar results were found among the populations in the total cholesterol level of ≥3.40 mmol/L compared to the populations in the total cholesterol level of &lt;3.40 mmol/L groups.ConclusionIn oldest old aged 85 and older, serum total cholesterol levels are inversely associated with all-cause mortality. This study suggested that total cholesterol should be maintained to acceptable levels (≥ 3.40 mmol/L) in oldest old to achieve longevity.
Air non-thermal plasma, a green approach for the treatment of contaminated water: the case of sulfamethoxazole
Authors: Giardina Agata , Lofrano Giusy , Libralato Giovanni , Siciliano Antonietta , Marotta Ester , Paradisi Cristina 
Published: June 2024

Non-thermal plasma (NTP) is gaining increasing attention as a promising approach for advanced water treatment to degrade persistent organic pollutants. Aqueous solutions of sulfamethoxazole (4-amino-N-(5-methylisoxazol-3-yl)-benzensulfonamide, SMZ), an antibiotic largely employed for humans and animals and a widespread persistent pollutant of waters and wastewaters, were subjected to air NTP treatment in a dielectric barrier discharge (DBD) reactor. The effects of SMZ initial concentration and of the solution pH on SMZ decomposition kinetics and transformation products were investigated. Efficient degradation was achieved, resulting in the complete removal of SMZ (10 μM initial concentration) in less than 25 min treatments, in the exhaustive mineralization (a result never reported before in plasma treatments and seldom reached also with other advanced oxidation processes) of all organic carbon in 6 h and in an energy efficiency of 6.4 g/kWh at 50% conversion. By means of HPLC-UV/Vis and LC-ESI-MSn analyses, a number of organic transformation products was identified along the path to SMZ mineralization, all present always in very small amounts and in turn decomposed at short treatment times. The effect of the solution pH on the genesis and decay of transformation products was also investigated. Based on comparisons with literature data and on previous findings obtained with the DBD reactor used in this work, it is concluded that the major reactive species involved in the degradation of SMZ are the hydroxyl radical and ozone. Finally, toxicological analyses of water initially containing 0.5 mM SMZ and subjected to 4 h NTP treatment showed that the by-products are not toxic to Raphidocelis subcapitata and Daphnia magna, while residual toxicity was detected by Aliivibrio fischeri.
Inflammatory bowel disease and rheumatoid arthritis share a common genetic structure
Authors: Cao Guoling , Luo Qinghua , Wu Yunxiang , Chen Guanghua 
Published: June 2024

BackgroundThe comorbidity rate of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is high; nevertheless, the reasons behind this high rate remain unclear. Their similar genetic makeup probably contributes to this comorbidity.MethodsBased on data obtained from the genome-wide association study of IBD and RA, we first assessed an overall genetic association by performing the linkage disequilibrium score regression (LDSC) analysis. Further, a local correlation analysis was performed by estimating the heritability in summary statistics. Next, the causality between the two diseases was analyzed by two-sample Mendelian randomization (MR). A genetic overlap was analyzed by the conditional/conjoint false discovery rate (cond/conjFDR) method.LDSC with specific expression of gene analysis was performed to identify related tissues between the two diseases. Finally, GWAS multi-trait analysis (MTAG) was also carried out.ResultsIBD and RA are correlated at the genomic level, both overall and locally. The MR results suggested that IBD induced RA. We identified 20 shared loci between IBD and RA on the basis of a conjFDR of &lt;0.01. Additionally, we identified two tissues, namely spleen and small intestine terminal ileum, which were commonly associated with both IBD and RA.ConclusionHerein, we proved the presence of a polygenic overlap between the genetic makeup of IBD and RA and provided new insights into the genetic architecture and mechanisms underlying the high comorbidity between these two diseases.
Association of serum ferritin and all-cause mortality in AKI patients: a retrospective cohort study
Authors: Ren Xiaoxu , Jiang Zhiming , Liu Fen , Wang Quanzhen , Chen Hairong , Yu Lifeng , Ma Chaoqun , Wang Rong 
Published: June 2024

BackgroundSerum ferritin (SF) is clinically found to be elevated in many disease conditions, and our research examines serum ferritin in patients with acute kidney injury (AKI) and its implication on the risk of short-term mortality in AKI.MethodsData were extracted from the Medical Information Mart for Intensive Care IV 2.2 (MIMIC-IV 2.2) database. Adult patients with AKI who had serum ferritin tested on the first day of ICU admission were included. The primary outcome was 28-day mortality. Kaplan–Meier survival curves and Cox proportional hazards models were used to test the relationship between SF and clinical outcomes. Subgroup analyses based on the Cox model were further conducted.ResultsKaplan–Meier survival curves showed that a higher SF value was significantly associated with an enhanced risk of 28-day mortality, 90-day mortality, ICU mortality and hospital mortality (log-rank test: p &lt; 0.001 for all clinical outcomes). In multivariate Cox regression analysis, high level of SF with mortality was significantly positive in all four outcome events (all p &lt; 0.001). This result remains robust after adjusting for all variables. Subgroup analysis of SF with 28-day mortality based on Cox model-4 showed that high level of SF was associated with high risk of 28-day mortality in patients regardless of the presence or absence of sepsis (p for interaction = 0.730). Positive correlations of SF and 28-day mortality were confirmed in all other subgroups (p for interaction&gt;0.05).ConclusionHigh level of SF is an independent prognostic predictor of 28-day mortality in patients with AKI.
Bioinformatic meta-analysis reveals novel differentially expressed genes and pathways in sarcoidosis
Authors: van Wijck Rogier T. A. , Sharma Hari S. , Swagemakers Sigrid M. A. , Dik Willem A. , IJspeert Hanna , Dalm Virgil A. S. H. , van Daele Paul L. A. , van Hagen P. Martin , van der Spek Peter J. 
Published: June 2024

IntroductionSarcoidosis is a multi-system inflammatory disease of unknown origin with heterogeneous clinical manifestations varying from a single organ non-caseating granuloma site to chronic systemic inflammation and fibrosis. Gene expression studies have suggested several genes and pathways implicated in the pathogenesis of sarcoidosis, however, due to differences in study design and variable statistical approaches, results were frequently not reproducible or concordant. Therefore, meta-analysis of sarcoidosis gene-expression datasets is of great importance to robustly establish differentially expressed genes and signalling pathways.MethodsWe performed meta-analysis on 22 published gene-expression studies on sarcoidosis. Datasets were analysed systematically using same statistical cut-offs. Differentially expressed genes were identified by pooling of p-values using Edgington’s method and analysed for pathways using Ingenuity Pathway Analysis software.ResultsA consistent and significant signature of novel and well-known genes was identified, those collectively implicated both type I and type II interferon mediated signalling pathways in sarcoidosis. In silico functional analysis showed consistent downregulation of eukaryotic initiation factor 2 signalling, whereas cytokines like interferons and transcription factor STAT1 were upregulated. Furthermore, we analysed affected tissues to detect differentially expressed genes likely to be involved in granuloma biology. This revealed that matrix metallopeptidase 12 was exclusively upregulated in affected tissues, suggesting a crucial role in disease pathogenesis.DiscussionOur analysis provides a concise gene signature in sarcoidosis and expands our knowledge about the pathogenesis. Our results are of importance to improve current diagnostic approaches and monitoring strategies as well as in the development of targeted therapeutics.