bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancement of Ca2+release from store-operated Ca2+ entry by Coronavirus disease 2019 (COVID19) spike (S) protein.
Authors: Kang Sang Sun , Kim Kiwol , Lee Eun Jeong 
Published: April 2024

Abstract
Functions and viral infection mechanisms of coronavirus disease 2019 (COVID-19) have been recently investigated extensively, focusing on Spike (S) protein together with its receptor, ACE2. Although their relationships with COVID-19 are obvious, less attention has been paid to intracellular regulation of S protein-protein interaction.
Here, we identified STIM1 (stromal interaction molecule 1 precursor) as a novel binding protein of S protein for the first time. Their association was further characterized. We found that S [1259DD1260] acidic motif specifically interacted with STIM1 C-terminal basic motif [671RKKFPLKIFKKPLKK685]. Both motifs were demonstrated to be essential for STIM1 and S protein interaction using immunoprecipitation and immunoblotting and confocal co-localization. We also elucidated that the association between the acidic tail motif of S protein and the C-terminal basic motif of STIM1 promoted Ca2+cytoplasmic release from the store-operated Ca2+ ion entry (SOCE) by disrupting STIM1 function, suggesting that disrupting STIM1 function by S protein was one of its mode of actions for COVID-19 infection.
For the first time, we demonstrated that S protein played a role as a Ca2+ ion releasing enhancer for COVID-19 infection from SOCE through interrupting normal STIM1’s roles. Our findings may provide one of the new ways for curing or preventing COVID-19 pandemic recurrence.
The Determinants of Agriculture Total Factor Productivity Dynamics in Sub-Saharan Africa – Evidence From 44 Countries (1961-2019)
Authors: Baion Yagbasuah Maada , Jianmin Cao , Yunxia Wang 
Published: April 2024

Abstract

This work estimates agricultural total factor productivity (TFP) change in 44 countries in the Sub-Saharan African (SSA) region for a period of 59 years, (1961–2019). We measure TFP by calculating the Malmquist productivity index (MPI) which decomposes the changes into technological change (techch), efficiency change (effch), scale efficiency change (sech) and pure efficiency change (pech). The determinants of agricultural total productivity changes are identified and their effects on TFP measured. We discover average annual decline of 0.975 in agriculture TFP largely due to a 0.975 technological regression during the study period. Our analysis of the determinants of TFP changes establishes that factors like land policies, good governance, conflict/war and credit to agriculture, influence TFP changes.
CNT Aerogel film based Novel Approach for Development of Ultra-Sensitive electrochemical Sensor Platforms with glassy carbon, screen-printed, and interdigitated electrodes
Authors: Prakash Jyoti 
Published: April 2024

Abstract
In sensor applications, the introduction of CNTs onto sensing substrates currently entails intricate processes with concerns over stability. This study demonstrate the utilization of CNT aerogel electrode as an ultrasensitive platform. Further introducing a novel approach employing a cast and pull-back technique along with drop-casting for successful binder less deposition of CNTs onto sensing substrates, utilizing a CNT aerogel film to augment the sensitivity of conventional glassy carbon electrodes (GCEs), screen-printed electrodes (SPEs), and interdigitated electrodes (IDEs). Scanning electron microscopy validates the deposition of CNT forests on GCE, entangled CNT networks on SPE, and IDE. Comparative electrochemical analyses reveal superior performance of CNT-incorporated SPE and GCE sensors, with the CNT aerogel electrode standing out prominently. Notably, CNT-incorporated SPE and GCE sensors demonstrate a respective approximately 12- and 2-fold increase in electrochemical active surface area, whereas the CNT aerogel electrode displays remarkable ~ 40-fold enhancement. For IDE, a significant 1700-fold change in resistance of IDE-CNT in the presence of a redox solution surpasses the 200-fold change observed in bare IDE, underscoring a substantial sensitivity enhancement facilitated by CNT incorporation. The mechanical integrity of CNT aerogel electrode post-exposure to liquids and sonication attests to its robust nature. The preservation of the deposited CNT forest on the SPE and GCE sensor platforms after multiple measurements further underscores its stability. This study positions the CNT aerogel electrode as a resilient and highly sensitive platform, particularly well-suited for the transfer of CNT networks onto diverse sensing substrates, thereby showcasing its potential to advance biomedical sensor technology.
Numerical Estimation of the Weibull Distribution Parameters Using Adams’s Method
Authors: Maswadah M. 
Published: April 2024

Abstract
Recently, numerical analysis has been used effectively for estimating the lifetime distribution parameters in the literature. Therefore, the main objective of this paper is to introduce a new numerical estimation technique, such as Adams’s method. This method has been used for estimating the Weibull model parameters and compare to the Bayesian estimations based on different priors via Monte Carlo simulations. The simulation results indicated that Adams’s method is more efficient than Bayes’ method. Finally, two real data sets have been analyzed for illustrations and to compare the proposed methods based on the generalized progressive hybrid censoring data.
Properties of spruce wood fibers affected by rot
Authors: Коптев С.В. , Васькин С.А. , Севастьянова Ю.В. , Поташев А.В. , Медведев В.В. 
Published: April 2024

В условиях Архангельской области преобладают хвойные леса, в первую очередь насаждения ели европейской (Pícea ábies), которые подвергаются активному хозяйственному освоению. Одной из причин снижения товарности еловых древостоев является воздействие дереворазрушающих грибов. В еловых насаждениях района исследований наиболее распространены базидиальные грибы: корневая губка (Heterobasidion annosum (Fr) Bref), и еловая губка (Phellinus chrysoloma), вызывающие пеструю коррозионную ядровую комлевую и стволовую гнили. Болезнь приводит к потере части деловой древесины, вызывает образование бурелома и ветровала. В связи с этим представляет интерес изучение процесса гниения древесины и возможности использования поврежденной гнилью древесины в промышленных целях. В лабораторных условиях были выполнены варки образцов древесины ели, пораженной коррозионными гнилями различной степени развития. Установлено, что в производственных условиях возможно использование древесины ели, пораженной коррозионной гнилью не выше 1 стадии без значительного снижения показателей качества полуфабриката. Целлюлоза, полученная из древесины ели, поврежденной гнилью 2, 3 и 4 стадий, характеризуется более низким выходом целлюлозы по сравнению с образцом, полученным из здоровой древесины. Структурно-морфологические характеристики волокон целлюлозы из поврежденной древесины имеют специфические особенности. Многие вопросы в отношении патогенных грибов, вызывающих основные болезни хвойных пород, остаются недостаточно изученными.
In the conditions of the Arkhangelsk region, coniferous forests predominate, and first of all, stands of European spruce (Pícea ábies), which are undergoing active economic development. One of the main reasons for the decreasing of spruce stands merchantable structure is the impact of wood-destroying fungi. Basidial fungi are most common in the spruce stands of the research area: root rot (Heterobasidion annosum (Fr) Bref), and spruce rot (Phellinus chrysoloma), causing variegated corrosive root and stem rot. The disease leads to the loss of part of the commercial wood, causes the windbreak and a windblow formation. In this regard, it is of interest to study the process of rotting wood and the possibility of using rot-damaged wood. Coniferous wood was cooked under laboratory conditions. It is established that in production conditions it is possible to use spruce wood affected by corrosive rot no higher than stage 1 without a significant decrease in the quality of the semi-finished product. Cellulose obtained from spruce wood damaged by rot of stages 2, 3 and 4 is characterized by a lower yield of cellulose compared to a sample obtained from healthy wood. The structural and morphological characteristics of cellulose fibers from damaged wood have specific features. Many questions regarding pathogenic fungi that cause the main diseases of conifers remain insufficiently studied.
Domestic access to water in a decentralized truck-to-cistern system: a case study in the Northern Village of Kangiqsualujjuaq, Nunavik (Canada)
Authors: Cassivi Alexandra , Carabin Anne , Dorea Caetano , Rodriguez Manuel J. , Guilherme Stéphanie 
Published: April 2024

ABSTRACT
Municipal water supply through truck-to-cistern systems is common in northern Canada. Household satisfaction and concerns about water services likely impact user preferences and practices. This case study explores household perspectives and challenges with regard to domestic access to water in a decentralized truck-to-cistern system. A case study was conducted in the Northern Village of Kangiqsualujjuaq, Nunavik (Quebec, Canada). A paper-based questionnaire was completed by 65 households (one quarter of the population). Many households (37%) reported not drinking tap water from the truck-to-cistern system. Chlorine taste was a frequently reported concern, with those households being significantly less likely to drink water directly from the tap (p = 0.002). Similarly, households that reported a water shortage in the previous week (i.e., no water from the tap at least once) (33%) were more likely to express dissatisfaction with delivered water quantity (rs = 0.395, p = 0.004). Interestingly, 77% of households preferred using alternative drinking water sources for drinking purposes, such as public tap at the water treatment plant, natural sources or bottled water. The study underscores the importance of considering household perspectives to mitigate the risks associated with service disruptions and the use of alternative sources for drinking purposes.
Prediction of In-Hospital Cardiac Arrest in the Intensive Care Unit: Machine Learning–Based Multimodal Approach
Authors: Lee Hsin-Ying , Kuo Po-Chih , Qian Frank , Li Chien-Hung , Hu Jiun-Ruey , Hsu Wan-Ting , Jhou Hong-Jie , Chen Po-Huang , Lee Cho-Hao , Su Chin-Hua , Liao Po-Chun , Wu I-Ju , Lee Chien-Chang 
Published: April 2024

Abstract

Background
Early identification of impending in-hospital cardiac arrest (IHCA) improves clinical outcomes but remains elusive for practicing clinicians.

Objective
We aimed to develop a multimodal machine learning algorithm based on ensemble techniques to predict the occurrence of IHCA.

Methods
Our model was developed by the Multiparameter Intelligent Monitoring of Intensive Care (MIMIC)–IV database and validated in the Electronic Intensive Care Unit Collaborative Research Database (eICU-CRD). Baseline features consisting of patient demographics, presenting illness, and comorbidities were collected to train a random forest model. Next, vital signs were extracted to train a long short-term memory model. A support vector machine algorithm then stacked the results to form the final prediction model.

Results
Of 23,909 patients in the MIMIC-IV database and 10,049 patients in the eICU-CRD database, 452 and 85 patients, respectively, had IHCA. At 13 hours in advance of an IHCA event, our algorithm had already demonstrated an area under the receiver operating characteristic curve of 0.85 (95% CI 0.815‐0.885) in the MIMIC-IV database. External validation with the eICU-CRD and National Taiwan University Hospital databases also presented satisfactory results, showing area under the receiver operating characteristic curve values of 0.81 (95% CI 0.763-0.851) and 0.945 (95% CI 0.934-0.956), respectively.

Conclusions
Using only vital signs and information available in the electronic medical record, our model demonstrates it is possible to detect a trajectory of clinical deterioration up to 13 hours in advance. This predictive tool, which has undergone external validation, could forewarn and help clinicians identify patients in need of assessment to improve their overall prognosis.
PENGARUH TEKNIK ANESTESI KOMBINASI BLOK SKALP DENGAN LEVOBUPIVACAINE 0,5% TERHADAP PENGGUNAAN FENTANYL INTRAVENA UNTUK MENGATASI NYERI PASKA OPERASI KRANIOTOMI PENGANGKATAN TUMOR DI RSUP DR. SARDJITO
Authors: Akbar Shonnif , Sudadi  , Widodo Untung , Widodo Untung 
Published: April 2024

Latar Belakang. Pengunaan opioid dosis besar terbukti efektif untuk memblokade stimulasi pada insisi kepala namun memiliki efek yang tidak diinginkan. Blok skalp adalah salah satu pilihan alternatif yang dapat dikombinasikan dengan pembiusan umum. Blok skalp sendiri dapat menumpulkan respon stres pada kraniotomi dan dapat menjaga gejolak hemodinamik yang tidak diinginkan. Blok skalp menurunkan insiden dan skala nyeri paska operasi kraniotomi pengangkatan tumor.
Tujuan. Membandingkan jumlah konsumsi fentanyl paska operasi pada pasien yang menjalani operasi kraniotomi pengangkatan tumor dengan teknik pembiusan umum dan teknik pembiusan umum dengan kombinasi blok skalp menggunakan levobupivacaine 0,5%.
Metode. Dua puluh orang pasien dengan rentang usia 18-65 tahun dengan tumor intrakranial yang menjalani tindakan operasi kraniotomi pengangkatan tumor di RSUP Dr. Sardjito dikelompokkan menjadi 2 kelompok perlakuan dengan teknik pembiusan umum dengan kombinasi blok skalp menggunakan levobupivacaine 0,5% dan pembiusan umum dengan kombinasi blok skalp menggunakan normal saline. Pasien dievaluasi kebutuhan fentanyl dan skala nyeri 12 jam paska operasi di ICU. Pasien dengan riwayat alergi anestesi lokal, riwayat alergi fentanyl, BMI <18 kg/m2 dan BMI >35 kg/m2 dan durasi operasi >6 jam akan dieksklusi dari pengambilan data.
Hasil. Rerata penggunaan fentanyl 12 jam paska operasi pada pasien yang menjalani operasi kraniotomi pengangkatan tumor dengan teknik pembiusan umum dengan kombinasi blok skalp menggunakan levobupivacaine 0,5% sebesar 300,50 mcg dengan standar deviasi 68,65 mcg. Sedangkan pada pasien dengan teknik pembiusan umum dengan kombinasi blok skalp menggunakan normal salin sebesar 408,75 mcg dengan standar deviasi 84,02 mcg. Selisih rerata penggunaan fentanyl paska operasi pengangkatan tumor antara kedua kelompok sebesar 108,25 mcg menunjukkan perbedaan yang bermakna p=0,006 (p<0,05).
Kesimpulan. Pembiusan umum dengan kombinasi blok skalp menggunakan levobupivacaine 0,5% terbukti mengurangi kebutuhan fentanyl 12 jam paska operasi kraniotomi pengangkatan tumor dibandingkan pembiusan umum dengan kombinasi blok skalp menggunakan normal salin.
A Case report Myasthenia Gravis
Authors: Adhinugroho Sudjati 
Published: April 2024

Krisis miastenia, didefinisikan sebagai kegagalan pernafasan yang membutuhkan ventilasi mekanik, terjadi pada 15 hingga 20% pasien dengan miastenia gravis (MG). Infeksi (biasanya pneumonia atau infeksi virus pernapasan atas adalah pencetus yang paling umum (40%), diikuti oleh tidak ada penyebab yang jelas (30%) dan aspirasi (10%). Pada umumnya, 25% pasien berhasil diekstubasi setelah 1 minggu, 50% setelah 2 minggu, dan 75% setelah 1 bulan. Trakeostomi dilakukan setelah intubasi lebih dari 2 minggu, usia lebih dari 50 tahun, Penggunaan serum bikarbonat 30 mg / dL atau lebih besar, dan kapasitas vital dalam 6 hari intubasi kurang dari 25 mL / kg.
Manajemen perawatan intensif pasien miastenia harus fokus pada intubasi tepat waktu, pencegahan aspirasi dengan pemberian makan tabung, dan menghindari komplikasi, seperti atelektasis, yang dapat memperpanjang durasi krisis. Plasmaferesis mengarah ke perbaikan jangka pendek kelemahan pada 75% pasien, dan harus dilakukan pada semua pasien kecuali sebaliknya kontraindikasi. Kelemahan sisa menyebabkan ketergantungan fungsional pada 50% pasien pada saat keluar, dan sepertiga akan mengalami dua atau lebih episode krisis.
Acumulación de materia seca, rendimiento y calidad nutricional del forraje de híbridos de maíz cosechados a diferentes días después de la siembra
Authors: Ramírez Gutiérrez Diego Eduardo , Olmos Colmenero José Jesús , Peña Ramos Alfonso , Sánchez Duarte Juan Isidro , Medina Núñez Ernesto , Gallardo Ramírez Siliviano , Santana Omar Ivan 
Published: April 2024

El objetivo fue evaluar la acumulación de materia seca (MS) por componente, rendimiento y composición nutricional del forraje de cuatro híbridos de maíz cosechados a 121, 128, 135 y 142 días después de la siembra. En cada cosecha, se tomaron al azar cinco plantas y se separaron en sus componentes (tallo, hojas, grano, olote, brácteas y espiga) y se determinó la MS; en una muestra compuesta de planta completa se analizó la composición química y digestibilidad in situ. La acumulación de grano en la MS total se incrementó de 35.8 a 43.9 % de los 121 a 142 días a cosecha, respectivamente, y diluyó a los demás componentes, sobre todo la proporción de tallo y de hojas, que decrecieron inversamente proporcional a la acumulación de grano. El contenido de MS total difirió entre híbridos de 3.8 y hasta 8.3 unidades porcentuales a mismos días a cosecha. Sin embargo, el híbrido no afectó el rendimiento de MS ni la producción de grano incrementándose 2.1 y 1.4 t ha-1 entre cosecha, respectivamente. El contenido de FDN disminuyó y el almidón se incrementó (ambos linealmente), afectando la energía neta de lactancia que aumentó de 1.49 a 1.56 Mcal kg-1 de los 121 a 142 días a cosecha, respectivamente. La interacción entre días a cosecha e híbrido afectó el contenido de almidón, el cual fue 5.2 unidades superior en un híbrido con similar contenido de CNF y FDN que sus contrapartes. Las digestibilidades de la MS, de la FDN y del almidón fueron afectadas por el híbrido, pero no por los días a cosecha.
Common Auditors in the Supply Chain and the Supplier’s Performance
Authors: Su Lixin , Zhang Yue , Zhao Jing , Zhuang Lei 
Published: April 2024

ABSTRACT
We examine the effect of a common auditor within a supply chain, where the auditor serves both the supplier and its customer(s). This dual role allows auditors to leverage and disseminate crucial chain-specific knowledge. Considering that supplier firms are relatively smaller and at a disadvantage compared with their customers, such supply-chain knowledge is valuable for suppliers to make better demand forecasts and business plans. Consistent with this argument, we find that a supplier sharing a common auditor with its customer(s) has a higher ROA, a higher profit margin, a shorter receivable conversion period, and a smaller demand distortion from the bullwhip effect. Performance enhancement is more pronounced when the common auditor has more opportunities to collect and transfer information and when such information transfer is more valuable to the supplier. Our results are robust to alternative measures of common-auditor presence, alternative explanations, and potential endogeneity concerns.
Data Availability: The data that support the findings of this study are openly available.
JEL Classifications: D82; D83; L25; M42.
Maximum Likelihood Estimation Approach using the CB-SEM Method: Case Study of Service Quality
Authors: Oktavia Putri Meyla , Setiawan Eri , Nusyirwan Nusyirwan , Herawati Netti 
Published: April 2024

The purpose of this study to analyze the service level, satisfaction and loyalty of Sariringgung Beach visitors.Covarian based approach to estimatemaximum likelihood method in the service levelto the satisfaction and loyalty of visitorstourism area of Sariringgung Beach is used. The results of this study indicate that the direct effect of service level to satisfaction is 77%, service level to loyalty is 75%. Whereas the indirect effect of service level on loyalty through satisfaction is 38,5%. Then the total effect of service level on customer loyalty through satisfaction is 73,5%.
The Use of Products from Leonardite to Improve Soil Quality in Condition of Climate Change
Authors: Pikuła Dorota 
Published: April 2024

Abstract
The principle of sustainable fertilisation in modern agriculture, which ensures that the soil is maintained in a fertile state requires the search for alternatives to manure fertilisation for products based on humic substances to increase the organic matter content of soils.The advantage of leonardite over conventional natural and organic fertilisers is mainly due to its high content of organic matter and humic substances (humic and fulvic acids). Leonardite, due to the presence of humic acids in it, can be suitable for soil amendment and yield of barley. In the conducted studies, the yield increase after adding Rosahumus fertilizer to the soil at a rate of 6 kg.ha−1 + NPK (Nitrogen, Phosphorus, Potasssium) was found to be 11% compared to the control (NPK).There were no changes in the Corg. content of the soil as a result of the application of Rosahumus fertilizer with NPK. The fertilizer only slightly modified the fractional composition of humus. In the future, we should expect an increase in the use of leonardite-derived humic substances in fertilizers and soil conditioners to stabilize soil organic matter.
A Case Study of RNA-Silencing Resistance against Potato Virus (PVY) in Condition of Climate Change
Authors: Isakhanova Saltanat , Kravka Miroslav , Klíč Radek 
Published: April 2024

Abstract
Global environmental issues shift crop production to the new conditions. This increases all kinds of biotic and abiotic stresses, beside others also plant diseases. Such changes are also in Kazakhstan where potato production is dramatically increasing, and crop is growing in regions with continental climate. Problems with potato virus type Y (PVY) need cultivars with better resistance. Introduction of silencing small interfering RNA (siRNA) is new technology. In vitro experiment was done on potato (Solanium tuberosum L.) local cultivar Izolda. Results show significant effect of siRNA in decreasing mortality and occurrence of PVY symptoms and allow expansion of potato cultivation to continental climate conditions, where are faced with new virus problems.
Economic benefit analysis of enterprises from multi-dimensional perspective based on K-means clustering
Authors: Wang Shuang 
Published: April 2024

Abstract
Economic benefit is the basic starting point of all economic activities that further developing financial advantages is helpful for improve the market seriousness of companies. The development of enterprises lessens work utilisation and acquires greatest advantages with the base speculation. Therefore, in this paper, the evaluation indices of economic benefit in enterprises are classified and the analysis model of economic benefit based on K-means clustering is established. According to the principal component analysis method, multi-dimensional analysis is conducted on X Company’s orders, income and expenditure data, loan amount and other aspects, which can help the senior leaders to scientifically manage and control the economic situation of the company, and make a better scientific forecast for future development.