bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene expression profiling from leukocytes of horses affected by osteochondrosis
Authors: Serteyn Didier , Piquemal David , Vanderheyden Laurent , Lejeune Jean‐Philippe , Verwilghen Denis , Sandersen Charlotte 
Published: January 2010

AbstractOsteochondrosis (OC) is a developmental disease that affects growing horses and that severely affects their ability to perform. The genetic basis of its pathogenesis is poorly understood. The aim of the study was to analyze the transcript profile of leukocytes from horses affected with OC. Two transcriptome libraries were constructed from leukocytes of OC‐affected and non–OC‐affected horses using digital gene expression analysis (DGE) and real‐time PCR. Statistical analysis allowed selection of 1,008 tags upregulated in the non–OC‐affected group and 1,545 tags upregulated in the OC‐affected group. Among these genes, 16 regulated genes and 5 housekeeping genes were selected. Metabolic pathways analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation or cartilage repair, including Wnt, Indian hedgehog, and TGF‐beta signaling. Other genes, including ISG, ApoB, MGAT4, and TBC1D9, showed a significantly different expression between groups. These genes may play a role in high carbohydrate diet, abnormal insulin metabolism, or inflammation, mechanisms suspected to be involved in OC. This DGE analysis of the transcript profile of leukocytes from OC‐affected horses demonstrated significant differences in comparison to the control library. These results open new perspectives for the understanding of equine OC. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:965–970, 2010
Correlating femoral shape with patellar kinematics in patients with patellofemoral pain
Authors: Harbaugh Calista M. , Wilson Nicole A. , Sheehan Frances T. 
Published: January 2010

AbstractThe etiology of patellofemoral pain is likely related to pathological femoral shape and soft‐tissue restraints imbalance. These factors may result in various maltracking patterns in patients with patellofemoral pain. Thus, we hypothesized that femoral shape influences patellofemoral kinematics, but that this influence differs between kinematically unique subgroups of patients with patellofemoral pain. 3D MRIs of 30 knees with patellofemoral pain and maltracking (“maltrackers”) and 33 knees of asymptomatic subjects were evaluated, retrospectively. Dynamic MRI was acquired during a flexion‐extension task. Maltrackers were divided into two subgroups (nonlateral and lateral maltrackers) based on previously defined kinematic criteria. Nine measures of femoral trochlear shape and two measures of patellar shape were quantified. These measures were correlated with patellofemoral kinematics. Differences were found in femoral shape between the maltracking and asymptomatic cohorts. Femoral shape parameters were associated with patellar kinematics in patients with patellofemoral pain and maltracking, but the correlations were unique across subgroups within this population. The ability to better categorize patients with patellofemoral pain will likely improve treatment by providing a more specific etiology of maltracking in individual patients. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:865–872, 2010
Temperature‐dependent low wavenumber Raman scattering studies in LiCsSO4 crystal
Authors: Kaczmarski M. , Wiesner M. 
Published: January 2010

AbstractThe Raman lattice modes in the LiCsSO4 crystal were measured in the temperature range of 17–303 K. Two right‐angle scattering geometries were used: z(xx)y and z(xz)y, to observe Ag and Bg (or B2g) modes, respectively. Critical phenomena were observed in the spectra at temperatures of about 200, 180 and 100 K. They correspond to structural phase transitions in the crystal from D2h to C2h at 200 K and to Cs symmetry at 100 K. The nature of the transition at 180 K is supposed to be of a lock‐in type, but it needs further investigation. Copyright © 2010 John Wiley & Sons, Ltd.
Dussertite BaFe3+3(AsO4)2(OH)5—a Raman spectroscopic study of a hydroxy‐arsenate mineral
Authors: Frost Ray L. , Bahfenne Silmarilly , Čejka Jiří , Sejkora Jiří , Plášil Jakub , Palmer Sara J. , Keeffe Eloise C. , Němec Ivan 
Published: January 2010

AbstractThe mineral dussertite, a hydroxy‐arsenate mineral with formula BaFe3+3(AsO4)2(OH)5, has been studied by Raman spectroscopy complemented with infrared spectroscopy. The spectra of three minerals from different origins were investigated and proved to be quite similar, although some minor differences were observed. In the Raman spectra of the Czech dussertite, four bands are observed in the 800–950 cm−1 region. The bands are assigned as follows: the band at 902 cm−1 is assigned to the (AsO4)3−ν3 antisymmetric stretching mode, the one at 870 cm−1 to the (AsO4)3−ν1 symmetric stretching mode, and those at 859 and 825 cm−1 to the As‐OM2 + /3+ stretching modes and/or hydroxyl bending modes. Raman bands at 372 and 409 cm−1 are attributed to the ν2 (AsO4)3− bending mode and the two bands at 429 and 474 cm−1 are assigned to the ν4 (AsO4)3− bending mode. An intense band at 3446 cm−1 in the infrared spectrum and a complex set of bands centred upon 3453 cm−1 in the Raman spectrum are attributed to the stretching vibrations of the hydrogen‐bonded (OH)− units and/or water units in the mineral structure. The broad infrared band at 3223 cm−1 is assigned to the vibrations of hydrogen‐bonded water molecules. Raman spectroscopy identified Raman bands attributable to (AsO4)3− and (AsO3OH)2− units. Copyright © 2010 John Wiley & Sons, Ltd.
The Montreal Cognitive Assessment as a screening tool for cognitive dysfunction in Huntington's disease
Authors: Videnovic Aleksandar , Bernard Bryan , Fan Wenqing , Jaglin Jeana , Leurgans Sue , Shannon Kathleen M. 
Published: January 2010

AbstractCognitive dysfunction is one of the hallmarks of Huntington's disease (HD) and may precede the onset of motor symptoms. The Montreal Cognitive Assessment (MoCA), a brief cognitive screening instrument with high specificity and sensitivity for detecting early cognitive impairments, has not been studied in the HD population. In this study, we compare the MoCA with the mini‐mental state examination (MMSE) as a screening tool for cognitive dysfunction among 53 patients with HD. The mean MMSE score was 26 ± 2.4, and mean MoCA score was 21 ± 4.4. Twenty‐one patients (81%) of those who scored ≥26 on the MMSE had the MoCA score <26. Thirty‐two patients (78%) of those who scored ≥24 on the MMSE had the MoCA score <24. The MoCA may be a more sensitive screening tool for cognitive impairments in HD relative to the MMSE. © 2010 Movement Disorder Society
Table tennis dystonia
Authors: Le Floch Anne , Vidailhet Marie , Flamand‐Rouvière Constance , Grabli David , Mayer Jean‐Michel , Gonce Michel , Broussolle Emmanuel , Roze Emmanuel 
Published: January 2010

AbstractFocal task‐specific dystonia (FTSD) occurs exclusively during a specific activity that usually involves a highly skilled movement. Classical FTSD dystonias include writer's cramp and musician's dystonia. Few cases of sport‐related dystonia have been reported. We describe the first four cases of FTSD related to table tennis (TT), two involving professional international competitors. We also systematically analyzed the literature for reports of sport‐related dystonia including detailed clinical descriptions. We collected a total of 13 cases of sport‐related dystonia, including our four TT players. Before onset, all the patients had trained for many years, for a large number of hours per week. Practice time had frequently increased significantly in the year preceding onset. As TT is characterized by highly skilled hand/forearm movements acquired through repetitive exercises, it may carry a higher risk of FTSD than other sports. Intensive training may result in maladaptive responses and overwhelm homeostatic mechanisms that regulate cortical plasticity in vulnerable individuals. Our findings support the importance of environmental risk factors in sport‐related FTSD, as also suggested in classical FTSD, and have important implications for clinical practice. © 2010 Movement Disorder Society
GCH1 mutation and clinical study of Chinese patients with dopa‐responsive dystonia
Authors: Liu Xin , Zhang Shu‐Shan , Fang Deng‐Fu , Ma Ming‐Yi , Guo Xiao‐Yan , Yang Yuan , Shang Hui‐Fang 
Published: January 2010

AbstractDopa‐responsive dystonia (DRD) is typically caused by heterozygous mutations in GTP cyclohydrolase 1 gene (GCH1). Our aim was to investigate the clinical and genetic features of Chinese DRD patients. We analyzed a cohort of Chinese DRD patients' clinical data. Mutation of the GCH1 gene was screened by direct sequencing. Additionally, multiplex ligation‐dependent probe amplification (MLPA) assay targeting the GCH1 and the TH gene to evaluate large exon deletion or duplicate mutation of the genes were performed in point mutation‐negative patients. Ten sporadic DRD patients and two pedigrees including six patients were included in the study. The onset age ranged from 3 to 15 years old. All patients initially presented with walking problems due to lower limb dystonia. The delay between onset and diagnosis ranged from 1 to 42 years old. The symptoms were completely or near‐completely abolished with low dose levodopa treatment (dosages ranged from 25 mg to 400 mg/day). Direct sequencing in 14 patients found two known mutations (Gly203Arg in exon 5 in four unrelated patients and Met102Lys in exon 1 in one patient) and one new mutation (Thr186Ile mutation in exon 5 in two unrelated pedigrees). A heterozygous exon 2 deletion in the GCH1 gene was found in one of three point mutation‐negative patients by MLPA analysis. Our clinical findings in DRD patients were consistent with other studies. GCH1 gene mutations were quite common in Chinese patients. MPLA should be performed in routine deletion analysis of GCH1 in point mutation‐negative DRD patients. © 2010 Movement Disorder Society
Incidence of Parkinson's disease and parkinsonism in northern Sweden: A population‐based study
Authors: Linder Jan , Stenlund Hans , Forsgren Lars 
Published: January 2010

AbstractThe differential diagnosis of parkinsonian disorders is difficult, especially early in the course of the diseases. The clinical subtypes of Parkinson's disease (PD) have not so far been described in newly diagnosed patients. We present a prospective incidence cohort study of patients with idiopathic parkinsonian syndromes in the Umeå region in northern Sweden identified over a 4‐year period. The clinical diagnoses were re‐evaluated at follow‐up visits at 12 months. We found 138 patients with parkinsonism: 112 PD, 12 multiple system atrophy with predominant parkinsonism (MSA‐P), six progressive supranuclear palsy (PSP) and eight unclassifiable patients. The crude incidences for all age ranges per 100,000 were: PD 19.7 (95% confidence interval 16.1–23.3); MSA‐P 2.1 (1.1–3.7); PSP 1.1 (0.4–2.4); idiopathic parkinsonism 24.3 (20.2–28.4). Age‐standardized to the average Swedish population 2004–2007: PD 22.5 (18.3–26.7); MSA‐P 2.4 (1.2–4.2); PSP 1.2 (0.4–2.6); idiopathic parkinsonism 27.5 (22.9–32.1). The crude annual incidence rate for PD, with exclusion of patients with normal dopamine receptor uptake (FP‐CIT‐SPECT), was 18.8 per 100,000 (95% confidence interval 15.2–22.4), age‐adjusted to the average Swedish population 2004 to 2007: 21.5 (17.4–25.6). The incidence rates did not differ significantly between men and women. The cumulative incidence of PD up to 89 years of age was for men 3.4%, for women 2.6%, and for both sexes combined 2.9%. The annual incidence rates found for PD, idiopathic parkinsonism, MSA‐P and PSP are among the highest reported. © 2010 Movement Disorder Society
The phenomenology of the geste antagoniste in primary blepharospasm and cervical dystonia
Authors: Martino Davide , Liuzzi Daniele , Macerollo Antonella , Aniello Maria Stella , Livrea Paolo , Defazio Giovanni 
Published: January 2010

AbstractThe geste antagoniste (GA), a relatively common feature of adult‐onset primary dystonia, has been systematically evaluated only in cervical dystonia, but it is still unclear whether its frequency and phenomenology differ among the various forms of focal dystonia. We analysed the frequency, phenomenology, effectiveness, and relationship of the GA with demographic/clinical features of dystonia in a representative clinical series of patients with the two most common forms of adult‐onset primary dystonia, blepharospasm (BSP) and cervical dystonia (CD). Clinical data were gathered using a standardized questionnaire, which showed substantial test‐retest reliability (κ = 0.79, P < 0.00001). The frequency of GA was similar among patients with BSP (42/59, 71.2%) and patients with CD (27/32, 84.4%), and in both groups GA showed similar effectiveness in reducing dystonia. The repertoire of GA was heterogenous in both BSP and CD patients, in whom seven BSP‐related and five CD‐related types of GA were recorded, and a “forcible” type of GA was present in 69% of BSP patients and in 48.1% of CD patients. In our whole patient population, age at dystonia onset was significantly lower among patients reporting a GA compared to those without GA (P = 0.01). GA features shared by BSP and CD predominate over differences, suggesting common mechanisms underlying this phenomenon in the two forms of primary adult‐onset dystonia. © 2010 Movement Disorder Society
Dynamic interactions between cells and their extracellular matrix mediate embryonic development
Authors: Goody Michelle F. , Henry Clarissa A. 
Published: January 2010

AbstractCells and their surrounding extracellular matrix microenvironment interact throughout all stages of life. Understanding the continuously changing scope of cell‐matrix interactions in vivo is crucial to garner insights into both congenital birth defects and disease progression. A current challenge in the field of developmental biology is to adapt in vitro tools and rapidly evolving imaging technology to study cell‐matrix interactions in a complex 4‐D environment. In this review, we highlight the dynamic modulation of cell‐matrix interactions during development. We propose that individual cell‐matrix adhesion proteins are best considered as complex proteins that can play multiple, often seemingly contradictory roles, depending upon the context of the microenvironment. In addition, cell‐matrix proteins can also exert different short versus long term effects. It is thus important to consider cell behavior in light of the microenvironment because of the constant and dynamic reciprocal interactions occurring between them. Finally, we suggest that analysis of cell‐matrix interactions at multiple levels (molecules, cells, tissues) in vivo is critical for an integrated understanding because different information can be acquired from all size scales. Mol. Reprod. Dev. 77: 475–488, 2010. © 2010 Wiley‐Liss, Inc.
Multiscale investigation of shear bands in sand: Physical and numerical experiments
Authors: Evans T. Matthew , Frost J. David 
Published: January 2010

AbstractIn many geotechnical systems, it is not uncommon to observe failure in zones of high localized strain called shear bands. The existing models predict the existence and the extent of these localizations, but provide little insight into the micromechanics within the shear bands. This research captures and compares the variation in microstructure both inside and outside of shear bands that formed in physical laboratory plane strain and companion numerical two‐dimensional discrete element method (DEM) biaxial compression experiments. Unsheared and sheared laboratory specimens of Ottawa 20–30 sand of varying dilatancy were solidified using a two‐stage resin impregnation procedure. The solidified specimens were sectioned and the resulting surfaces were prepared for microstructure observation using optical bright‐field microscopy and stereological analysis. Statistical properties of microstructural parameters for sub‐regions in a grid pattern and along predefined inclined zones were determined. Similar measurements were performed on 2D DEM simulation specimens at varying strain levels to characterize the evolution of microstructure with increasing strain. The results showed how differences evolved in the mean, standard deviation, and entropy of void distributions with increasing global strain levels. The results indicate how disorder increases and that the material within the shear band does not adhere to the classical concept of critical state, but reaches a terminal void ratio that is largely a function of initial void ratio. Furthermore, there appears to be a transition zone between the far field and the fully formed shear block, as opposed to an abrupt delineation as is traditionally inferred. Copyright © 2010 John Wiley & Sons, Ltd.
Micromechanical parameters in bonded particle method for modelling of brittle material failure
Authors: Kazerani T. , Zhao J. 
Published: January 2010

AbstractBonded particle modelling (BPM) is nowadays being extensively used for simulating brittle material failure. In BPM, material is modelled as a dense assemblage of particles (grains) connected together by contacts (cement). This sort of modelling seriously depends on the mechanical properties of particle and contact, which are named here as micro‐parameters. However, a definite calibration methodology to obtain micro‐parameters has not been so far established; and many have reported some serious problems. In this research, a calibration procedure to find a unique set of micro‐parameters is established. To attain this purpose, discrete element code of UDEC is used to perform BPM. This code can be conveniently developed by the user. The proposed BPM is composed of rigid polygonal particles interacting at their contact points. These contacts can undergo a certain amount of tension, and their shear resistance is provided by cohesion and friction angle. The results demonstrate that each material macro‐property (i.e. Young's modulus, Poisson's ratio, internal friction angel, internal cohesion, and tensile strength) is directly originated from and distinctly related to the contact properties (i.e. normal and shear stiffness, friction angel, cohesion, and tensile strength). Copyright © 2010 John Wiley & Sons, Ltd.
Parental perceptions of the outcome and meaning of normalization
Authors: Knafl Kathleen A. , Darney Blair G. , Gallo Agatha M. , Angst Denise B. 
Published: January 2010

AbstractThe purpose of this secondary analysis was to identify the meaning of normalization for parents of a child with a chronic genetic condition. The sample was comprised of 28 families (48 parents), selected to reflect two groups: Normalization Present (NP) and Normalization Absent (NA). Constant comparison analysis was used to identify themes characterizing parents' perceptions of the meaning of normalization. The meanings parents attributed to normalization reflected their evaluation of condition management, parenting role, and condition impact, with parents in the NP and NA groups demonstrating distinct patterns of meaning. These meaning patterns are discussed as an outcome of normalization. Providers can play a pivotal role in helping families achieve normalization by providing guidance on how to balance condition management with normal family life. © 2010 Wiley Periodicals, Inc. Res Nurs Health 33:87–98, 2010
Therapeutic drug monitoring of asparaginase in the ALL‐BFM 2000 protocol between 2000 and 2007
Authors: Schrey Dominik , Borghorst Stephan , Lanvers‐Kaminsky Claudia , Hempel Georg , Gerß Joachim , Möricke Anja , Schrappe Martin , Boos Joachim 
Published: January 2010

AbstractBackgroundOn a voluntary basis therapeutic drug monitoring (TDM) was implemented in the ALL‐BFM 2000 protocol for the three currently used asparaginase (ASNase) preparations (first line: native Escherichia coli ASNase; second line: pegylated ASNase and third line: Erwinia chrysanthemi ASNase).ProcedureBetween 2000 and 2007, 2,074 ASNase samples from 763 patients out of 114 hospitals were evaluated (5,000 U/m2 E. coli ASNase (n = 318), 1,000 U/m2 pegylated ASNase (n = 416) and 10,000 U/m2 Erwinia chrysanthemi ASNase (n = 29)).ResultsFirst‐line therapy with 5,000 U/m2 E. coli ASNase resulted in an ASNase activity of <100 U/L in 10% of all samples from day +3 after administration. Second‐line treatment with 1,000 U/m2 PEG ASNase led to activity values below 100 U/L in approximately 30% of all samples taken +7 days. Relating ASNase activity to route of administration, 10,000 U/m2 Erwinia ASNase IM compared to IV as third‐line treatment, led to a higher median activity (IM: median 151.5 U/L, range (0–750 U/L); IV: median 115 U/L, range (0–884 U/L), P = 0.3) and fewer samples below 100 U/L (IM: 15% vs. IV: 45%) at day +2.ConclusionThe reduced dose of 5,000 U/m2 E. coli ASNase for induction treatment succeeded to achieve an activity level above 100 U/L in more than 90% of all samples. They confirm that dose reduction is reasonable and provide the basis for future treatment strategies employing ASNase. Pediatr Blood Cancer 2010;54:952–958 © 2010 Wiley‐Liss, Inc.
Hypertensive disorders in pregnancy: combined screening by uterine artery Doppler, blood pressure and serum PAPP‐A at 11–13 weeks
Authors: Poon Leona C. Y. , Stratieva Violeta , Piras Silvia , Piri Solmaz , Nicolaides Kypros H. 
Published: January 2010

AbstractObjectiveTo explore if the addition of pregnancy‐associated plasma protein‐A (PAPP‐A) to maternal factors and biophysical markers yields a significant improvement in the detection of hypertensive disorders before the clinical onset of disease.MethodsProspective screening study for early preeclampsia (PE), late PE and gestational hypertension (GH) in women attending their first hospital visit at 11+0–13+6 weeks of gestation. The performance of screening for PE and GH by combinations of maternal factors, uterine artery with the lowest pulsatility index (L‐PI), mean arterial pressure (MAP) and serum PAPP‐A was determined.ResultsThere were 8061 unaffected controls, 37 of whom developed early PE, 128 with late PE and 140 with GH. Compared to the controls, in early PE and late PE MAP and uterine artery L‐PI were increased and PAPP‐A was decreased. In GH PAPP‐A was not significantly different from controls. In screening for a combination of maternal factors, uterine artery L‐PI, MAP and PAPP‐A the detection rate of early PE was 83.8%, at a 5% false‐positive rate. In the prediction of late PE and GH there was no significant improvement from the addition of PAPP‐A to the combination of maternal factors, MAP and uterine artery L‐PI.ConclusionMeasurement of PAPP‐A improves the performance of screening for early PE provided by a combination of maternal factors and biophysical tests at 11–13 weeks. Copyright © 2010 John Wiley & Sons, Ltd.
Component failure rate data sources for probabilistic safety and reliability
Authors: Cadwallader L.C. , Eide S.A. 
Published: January 2010

AbstractProbabilistic safety methods, which are being used in the chemical, manufacturing, and energy industries, create a basic need for input data on failure rates of the mechanical, electrical, instrumentation and control, and other components that comprise the engineering systems in a facility. Some companies have data stored and easy to retrieve. Other companies hire consultants who use their own databases to perform safety assessments. For analysts who do not have either of these options available, this article presents data sources that are retrievable from the literature. The accessibility of data documents via the internet is also described. © 2010 American Institute of Chemical Engineers Process Saf Prog, 2010