bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Same-Sex Marriage Laws on Health Care Use and Expenditures in Sexual Minority Men: A Quasi-Natural Experiment
Authors: Hatzenbuehler Mark L. , O'Cleirigh Conall , Grasso Chris , Mayer Kenneth , Safren Steven , Bradford Judith 
Published: December 2011

Objectives. We sought to determine whether health care use and expenditures among gay and bisexual men were reduced following the enactment of same-sex marriage laws in Massachusetts in 2003. Methods. We used quasi-experimental, prospective data from 1211 sexual minority male patients in a community-based health center in Massachusetts. Results. In the 12 months after the legalization of same-sex marriage, sexual minority men had a statistically significant decrease in medical care visits (mean = 5.00 vs mean = 4.67; P = .05; Cohen's d = 0.17), mental health care visits (mean = 24.72 vs mean = 22.20; P = .03; Cohen's d = 0.35), and mental health care costs (mean = $2442.28 vs mean = $2137.38; P = .01; Cohen's d = 0.41), compared with the 12 months before the law change. These effects were not modified by partnership status, indicating that the health effect of same-sex marriage laws was similar for partnered and nonpartnered men. Conclusions. Policies that confer protections to same-sex couples may be effective in reducing health care use and costs among sexual minority men.
The Late Cenozoic evolution of the Aksu basin (Isparta Angle; SW Turkey). New insights
Authors: Poisson André , Orszag-Sperber Fabienne , Kosun Erdal , Bassetti Maria-Angella , Müller Carla , Wernli Roland , Rouchy Jean-Marie 
Published: December 2011

Abstract
The Mio-Pliocene basins around the Antalya gulf in SW Turkey developed above the Tauric Mesozoic platforms on which the Antalya nappes had been thrusted (in Late Cretaceous-Paleocene times). The closure of the initial Isparta Angle during these events (E-W compression) initiated the N-S orientation of the main structural lines, which persisted later and explains the orientation of the Aksu basin in contrast with the E-W orientation of the eastern Neo-gene Mediterranean basins. The area, and all southwestern Turkey, became emergent at the end of the Oligocene and were the site of shallow-marine carbonate deposits in the Chattian-Aquitanian, giving way to the wide Lycian basin in Burdigalian-Langhian times. The progressive emplacement of the Lycian nappes from the north over this basin provoked first its subsidence and then its emersion when the nappes attained their final position over the Bey Daglari platform in Langhian times. Coinciding, or in response to the Lycian nappes emplacement, the Aksu basin was initiated as an elongated N-S graben which was filled by thick accumulations of terrestrial and marine deposits(including coral reefs), which derived from the erosion of the Lycian allochton and its basement (Langhian?, Serravallian and Tortonian times). The syn-sedimentary tectonics : reactivation of the normal faults along the west margin of the basin, the continuous uplift of the neighbouring continental areas (beginning of the Aksu thrust), governed the geometry of the basin. As a result and due to the uplift of its northern margin, the Aksu basin migrated towards the south and in Messinian times it was reduced to a narrow gulf along the eastern margin of which the Gebiz limestones were deposited as fringing coral reefs. The age of these limestones has been debated. Our new data allow us to attribute them to the Messinian. The drastic retreat of the sea at the end of this period, provoked the erosion of large parts of the Messinian deposits and the formation of deep canyons on land and under the sea down to the Antalya abyssal plain, in which evaporites were deposited. During the Zanclean transgression, the Eskiköy-Kargi canyon was filled by coarse clastics of a Gilbert delta derived from the northern continental area following a model well known elsewhere in the Mediterranean basins. Southward, shallow-marine sands and marls unconformably cover the remnants of the Messinian deposits and the emergent areas of the southern Antalya gulf. After Zanclean times (end of Pliocene?), the Aksu basin was deformed, due to the west-directed Aksu compressional event (end of the Aksu thrust). Quaternary terraces of the Aksu river at various altitudes, as well as the terraces of the Antalya tufa can be related to sea level fluctuations.
Refining our knowledge of the Messinian salinity crisis records in the offshore domain through multi-site seismic analysis
Authors: Lofi Johanna , Sage Françoise , Déverchère Jacques , Loncke Lies , Maillard Agnès , Gaullier Virginie , Thinon Isabelle , Gillet Hervé , Guennoc Pol , Gorini Christian 
Published: December 2011

AbstractThe Messinian salinity crisis (MSC) [Hsü et al., 1973] has deeply shaped the Mediterranean landscape and triggered large sedimentary deposits (evaporites and clastics) in the deep basins within a short time span. Until recently, the MSC has mainly been analyzed independently, either through outcrops located onshore (e.g. Morocco, Cyprus, Spain, Sardinia, Italy) or through marine seismic profiles in the deep offshore. Each approach bears its own limitations: (1) on the one hand, land outcrops refer to incomplete Messinian successions that are geometrically disconnected from the offshore Messinian deposits owing to tectonics (e.g. Apennines) and/or because they accumulated at an early stage of the crisis in shallow marginal basins (e.g. Spain); (2) on the other hand, seismic profiles from the upper margins down to the deep basins allow to image and explore the entire MSC event as a continuous process, but with a lower resolution and with a lack of stratigraphical and lithological control, in the absence of full recovery of scientific boreholes.We present here a synthesis of a set of modern geophysical data over the Mediterranean and Black seas allowing to image the Messinian markers (erosion surfaces, depositional units and their bounding surfaces) much better than previously and to study the spatio-temporal organisation of these markers from the inner-shelves down to the bathyal plains. The results from thirteen areas located offshore are compared, with common charts and nomenclatures. The comparative and multi-site approach developed here allows to analyse the record of the MSC on margin segments and basins that depict various structural, geodynamical and geological settings, to fix a number of local influencing factors (tectonics, subsidence, inherited topography, sedimentary fluxes...) and to partly assess their influence in facies and geometrical variations of the MSC units. We are thus able to extract from our analysis some recurrent signals related to the MSC ss., allowing us to discuss: (1) the amplitude and modalities of base-level changes during the MSC; (2) the depositional modalities of the MSC units in the deep basins; (3) the location of the erosion product of the margins and to emphasise (4) the major differences between the eastern and western Mediterranean basins.
A Different Model for Doctoral Education in Accounting and Auditing: Student and Faculty Reflections
Authors: Bishop Carol C. , Boyle Douglas M. , Clune Richard R. , Hermanson Dana R. 
Published: December 2011

SUMMARY
One proposed solution to the accounting and auditing faculty shortage is to expand the supply of AACSB-accredited professional or executive accounting doctoral programs (AACSB 2003; Trapnell et al. 2009), programs that are more flexible than traditional Ph.D. programs and are targeted to experienced professionals. This paper provides information about non-traditional doctoral programs and discusses the four co-authors' personal experiences in such programs. We believe that the insights will be useful both to prospective doctoral students (i.e., current practitioners and executives seeking to transition into academic careers) and to academics considering the development of such programs, or even hiring graduates from such programs.
Palliative ultrasound-guided endoscopic diode laser ablation of transitional cell carcinomas of the lower urinary tract in dogs
Authors: Cerf Dean J. , Lindquist Eric C. 
Published: December 2011

Abstract
Objective—To describe the development of ultrasound-guided endoscopic diode laser ablation for palliative management of urinary tract obstruction due to transitional cell carcinoma (TCC).
Design—Prospective case series.
Animals—38 dogs with urinary tract obstruction or potential obstruction caused by TCC.
Procedures—Diagnosis of TCC of the urinary bladder and urethra was made by means of transabdominal ultrasonography and transurethral endoscopic biopsy. Transurethral endoscopic near-infrared diode laser ablation was performed to debulk and remove obstructive and potentially obstructive TCC lesions. Transabdominal ultrasonography permitted proper alignment of the endoscope and laser fiber for monitoring laser fiber penetration and subsequent tissue alteration or ablation. The primary outcome measured was median survival time.
Results—Median survival time for all dogs was 380 days, with a range of 11 to 1,906 days. There was no significant difference in survival time between dogs that had TCCs with urethral involvement versus dogs that had TCCs without urethral involvement. Complications were stranguria, hematuria, stenosis at the cystourethral junction, spread of TCC within the lower urinary tract, spread to the urethrostomy site, urethral perforation, and bacterial cystitis.
Conclusions and Clinical Relevance—Results suggested that ultrasound-guided endoscopic diode laser ablation holds promise as a palliative treatment for dogs with TCC of the urinary tract. Ultrasonographic guidance and monitoring during laser irradiation was a useful addition to endoscopically applied transurethral diode laser ablation.
Comparison of short-term complication rates between dogs and cats undergoing appositional single-layer or inverting double-layer cystotomy closure: 144 cases (1993–2010)
Authors: Thieman-Mankin Kelley M. , Ellison Gary W. , Jeyapaul Cynthia J. , Glotfelty-Ortiz Carmen S. 
Published: December 2011

Abstract
Objective—To compare short-term complication rates in dogs and cats undergoing cystotomy closure by use of an inverting double-layer pattern (group I) versus cystotomy closure by use of an appositional single-layer pattern (group A).
Design—Retrospective case series.
Animals—144 client-owned dogs and cats that underwent cystotomy between 1993 and 2010.
Procedures—Information on signalment, reason for cystotomy, method of cystotomy closure, complications that developed during hospitalization, and duration of hospitalization were obtained from the medical record. The effect of closure technique on short-term complication rate and duration of hospitalization was examined.
Results—2 of the 144 animals developed dehiscence and uroabdomen following cystotomy closure: 1 from group A and 1 from group I. Of group A animals, 29 of 79 (37%) developed minor complications such as hematuria and dysuria. Of group I animals, 33 of 65 (50%) developed the same complications. Group A and group I animals did not differ significantly with regard to prevalence of minor or major complications. The mean duration of hospitalization was 4.1 days and did not differ significantly between groups.
Conclusions and Clinical Relevance—An appositional single-layer suture pattern for cystotomy closure was a safe and effective procedure with minimal risk of urine leakage and a short-term complication rate of 37%. The appositional single-layer suture pattern for cystotomy closure may be recommended for clinical use because the inverting double-layer suture pattern offered no clear advantage.
Use of magnetic resonance imaging and histopathologic findings for diagnosis of an aneurysmal bone cyst in the scapula of a cat
Authors: Benamou Jérôme , Lussier Bertrand , Alexander Kate , Gains Malcolm J. , Savard Claudine 
Published: December 2011

Abstract
Case Description—An 18-month-old spayed female domestic shorthair cat was evaluated because of left thoracic limb lameness.
Clinical Findings—A firm mass was palpable in the left scapular region. On the basis of clinical signs; results of radiographic, ultrasonographic, and cytologic evaluations; and findings on magnetic resonance imaging, an aneurysmal bone cyst (ABC) of the scapula was strongly suspected.
Treatment and Outcome—Considering the large size of the mass and the poor prognosis for return to function of the left thoracic limb, amputation was elected. Histologic evaluation ruled out a malignant process and was diagnostic for ABC originating from the left scapula. The patient recovered well and was ambulatory the day after surgery. Three years after surgery, the cat was healthy.
Clinical Relevance—The combination of radiography, regional ultrasonography, and magnetic resonance imaging enabled lesion structure and cavity content evaluation. However, final diagnosis was confirmed by histologic evaluation. To our knowledge, this is the first veterinary report of the use of magnetic resonance imaging in the characterization and diagnosis of an ABC.
Antivirals for Management of Herpes Zoster Including Ophthalmicus: A Systematic Review of High-Quality Randomized Controlled Trials
Authors: McDonald Elissa M , de Kock Johannes , Ram Felix SF 
Published: December 2011

Background There is lack of consensus from randomized controlled trials on the efficacy of antivirals in the management of herpes zoster. Therefore, a systematic review and meta-analysis was undertaken to provide better understanding of effectiveness of antivirals in management of herpes zoster. Methods A total of 12 randomized controlled trials with 7,277 patients were included in the review. Trials compared one antiviral to another (aciclovir, valaciclovir, famciclovir or brivudin) for a minimum of 7 days in immunocompetent patients presenting with herpes zoster diagnosed within 72 h of symptom onset. Primary outcome was reduction in pain. Results Compared with aciclovir, valaciclovir showed significant reduction in herpes-zoster-associated pain up to 112 days. The largest risk reduction in pain (36%) was seen at 21–30 days (relative risk [RR] 0.64, 95% CI 0.59, 0.70) with number needed to treat to benefit (NNT) of 3 (95% CI 2.7, 3.8). Famciclovir was also superior to aciclovir with a 46% reduction in risk of pain at 28–30 days (RR 0.54, 95% CI 0.48, 0.68) with NNT of 3 (95% CI 2, 5). Time to lesion healing and adverse effect profile was comparable. Conclusions Evidence from quality trials have shown significant reduction in risk of pain with valaciclovir and famciclovir for management of herpes zoster including ophthalmicus. Valaciclovir or famciclovir should be preferred treatment options in patients with herpes zoster as they both provide significant reduction in risk of herpes-zoster-associated pain. Furthermore, the superior pharmacokinetics and more convenient dosing regimens with the use of valaciclovir and famciclovir clearly make them the preferred treatment option.
Recurrent Corneal Erosion following Uneventful IntraLASIK Treated by Phototherapeutic Keratectomy
Authors: Kremer Israel 
Published: December 2011

Purpose To report on phototherapeutic keratectomy (PTK) in myopic patients who developed spontaneous recurrent corneal erosions (RCE) following IntraLASIK. Methods Recurrent corneal erosions developed spontaneously 3-6 months following IntraLASIK in 4 eyes of 4 myopic patients. Diffuse lamellar keratitis (DLK) subsequently developed. Initially, all patients underwent mechanical scraping of the loose epithelium. The erosion healed but recurred after 2-4 months. Phototherapeutic keratectomy was performed following scraping of the whole loose flap epithelium. The ablation diameter was 6.5 mm, transition zone was 2.7 mm, and the depth was 12 μm. This program was followed by a refractive laser treatment to correct +0.75 diopter at a zone of 6.0-9.0 mm. Results Recurrent corneal erosions healed completely following PTK within 8-10 days and DLK disappeared gradually within 9-12 days. Steroid drops were continued for 6-10 weeks according to degree of stromal haze. Final refraction revealed no significant change. Visual rehabilitation was noted to be slow. No patient lost best-corrected visual acuity. A +1-degree reticular haze was noted in all patients 4.5 years following treatment. The patients remained asymptomatic and corneal erosion did not recur during the follow-up period. Conclusions Phototherapeutic keratectomy was found to be an effective treatment for late spontaneous RCE after IntraLASIK and prevented recurrences. A mild stromal haze remained after laser treatment without loss of best-corrected visual acuity.
Pediatric Respiratory Syncytial Virus Hospitalizations, 2017-2023
Authors: Fitzpatrick Tiffany , Buchan Sarah A. , Mahant Sanjay , Fu Longdi , Kwong Jeffrey C. , Stukel Therese A. , Guttmann Astrid 
Published: June 2024

ImportanceRespiratory syncytial virus (RSV) transmission was disrupted worldwide following the COVID-19 pandemic, and further study is required to better understand these changes.ObjectiveTo compare observed and expected RSV hospital and intensive care unit (ICU) admission rates and characteristics of admitted children during the 2021-2022 and 2022-2023 seasons.Design, Setting, and ParticipantsA population-based cohort study of all children aged younger than 5 years in Ontario, Canada, July 1, 2017, through March 31, 2023, was conducted.ExposuresIndividual and neighborhood-level sociodemographic and clinical characteristics were identified from administrative data, including age, palivizumab eligibility, complex medical conditions, rurality, and living in a marginalized neighborhood.Main Outcomes and MeasuresThe main outcome was RSV-associated hospitalization. Secondary outcomes included ICU admissions, mechanical ventilation, extracorporeal membrane oxygenation, and in-hospital death. Poisson generalized estimating equations were used to model weekly age- and sex-specific hospitalization rates and estimate expected rates in the postpandemic era; adjusted rate ratios (RRs) and 95% CIs are reported.ResultsThis cohort study included approximately 700 000 children per study year. Compared with prepandemic years (2017-2018, 2018-2019, and 2019-2020), the 2021-2022 RSV season peaked slightly earlier, but overall admission rates were comparable (289.1 vs 281.4-334.6 per 100 000, or approximately 2000 admissions). The 2022-2023 season peaked a month earlier and resulted in more than twice as many hospitalizations (770.0 per 100 000; n = 4977 admissions). The proportion of children admitted to an ICU in 2022-2023 (13.9%) was slightly higher than prepandemic (9.6%-11.4%); however, the population-based rate was triple the prepandemic levels (106.9 vs 27.6-36.6 per 100 000 children in Ontario). With the exception of palivizumab-eligible children, all sociodemographic and health status characteristics were associated with lower-than-expected RSV hospitalization rates in 2021-2022. In contrast, older age of patients was associated with higher-than-expected rates in 2022-2023 (ie, 24-59 months: RR, 1.90; 95% CI, 1.35-2.66).Conclusions and RelevanceThere were notable differences in RSV epidemiologic characteristics in Ontario following the COVID-19 pandemic. It is not yet clear whether and how long atypical RSV epidemics may persist. Clinicians and program planners should consider the potential for ongoing impacts to health care capacity and RSV immunization programs.
Open‐Shelled Covalent–Organic Frameworks Based on Organic Mixed‐Valence Systems with NIR‐II Absorption for Solar‐Heating Activation
Authors: He Mingxu , Hu Yuan , Song Qiuyan , Wang Wenjing , Xu Weiquan , Zhao Jie , Ma Mingjun , Zhao Shuai , Fan Kaijie , Nie Jun , Chang Yincheng 
Published: June 2024

AbstractA novel kind of open‐shelled covalent–organic framework (TPAPL‐COF‐OX) is fabricated based on organic mixed‐valence (MV) systems, which is used for aromatic volatile organic compounds (VOCs) adsorption and activation without the artificial energy consumption. The triphenylamine nucleus endow TPAPL‐COF with an abundance of nitrogen‐active sites. A mild oxidation process on TPAPL‐COF results in the generation of MV structures (TPAPL‐COF‐OX), enhancing its absorption capacity into the NIR‐II region. The nitrogen‐rich TPAPL‐COF‐OX exhibits exceptional adsorption capabilities for VOCs. Its broad light absorption spanning from UV to NIR‐II regions endow it with remarkable photothermal properties, enabling it to attain activation temperatures under sunlight without artificial energy consumption. It is expected that this study may present a novel strategy for managing VOCs by solar‐heating activation with energy‐efficient advantages.
An Antioxidant, Reusable Laser Printed and Recycled Cork Paper Packaging
Authors: Zhai Wenxiang , Zhong Yijing , Xu Min , Wei Xinli , Cai Liping , Xia Changlei , Wei Yunzhao 
Published: June 2024

AbstractIn the realm of food waste recycling, industrial suberoligneous by‐products like cork and peels, pose a challenge for value‐added conversion, primarily due to their intricate structures. This study introduces an innovative approach by utilizing recycled cork as a prime example of repurposing food waste to create a reusable and durable packaging paper. Notably, the manufacturing process of this cork‐based paper avoids the generation of waste liquids from lignin removal, effectively alleviating concerns related to liquid waste pollution. The resulting packaging paper demonstrates remarkable printability, readability, and erasability while offering reusability. Its performance can be fine‐tuned through pH value adjustments. Moreover, this packaging paper exhibits outstanding antioxidative properties and barrier properties, seamlessly integrating superb UV‐blocking proficiency and heightened visible transparency, rendering it highly appealing for sustainable food packaging applications.
Engineered‐Doping Strategy for Self‐Sufficient Reactive Oxygen Species Blossom to Amplify Ferroptosis/Cuproptosis Sensibilization in Hepatocellular Carcinoma Treatment
Authors: Hu Jiahe , Zhu Jiuxin , Wang Kuan , Yan Xiuwei , Xu Lei , Zhang Xiaoling , Ding He , Yang Piaoping , Hu Shaoshan , Xie Rui 
Published: June 2024

AbstractFerroptosis and cuproptosis are emerging modes of programmed cell death and have been increasingly used to eliminate tumor cells. However, converting ferroptosis/cuproptosis into effective treatments is challenging because of the inherent antioxidant and plasma membrane repair systems and inefficient copper ion delivery. Herein, an engineered doping method is developed to encapsulate ZnO2 with Cu2+‐doped ZIF‐8 and modify the surface by transferrin (Tf). In the resulting ZnO2@Cu/ZIF‐8‐Tf nanosystem, Tf specifically binds to transferrin receptors for targeting and aggregation. In the tumor microenvironment, Cu2+/Fe3+ is released from the nanosystem and reacted with glutathione (GSH) to produce Cu+/Fe2+. Excessive accumulation of Cu+ interfered with the tricarboxylic acid cycle and induced coproptosis. Furthermore, the additional Fe2+ caused iron overload and enhanced ferroptosis. ZnO2 supplied hydrogen peroxide to mediate the overproduction of reactive oxygen species (ROS). Moreover, the depletion of GSH deactivated glutathione peroxidase 4 (GPX4) and inhibited the system Xc−‐GSH‐GPX4 pathway, and the amplified ROS triggered lipid peroxidation and reprogrammed lipid metabolism, causing malfunctioning of both antioxidant and membrane repair systems. In summary, the ferroptosis/cuproptosis pathways are activated at multiple levels in the ZnO2@Cu/ZIF‐8‐Tf nanosystem, which ensures its outstanding antitumor effect.