bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi pengembangan konsep Green Tourism pada Kawasan Wisata Malioboro Kota Yogyakarta
Authors: Nugroho Wildan Wahyu , Putri Ari Ananda 
Published: February 2025

<p><span id="docs-internal-guid-84a5b314-7fff-7d67-9988-f4559a66defe"><span>Kota Yogyakarta dikenal sebagai salah satu destinasi wisata budaya dengan salah satu daya tarik wisatawan yaitu Kawasan Malioboro. Salah satu moda yang sering digunakan oleh wisatawan adalah bus pariwisata dengan 3 (tiga) titik lokasi parkir khusus bus pariwisata yaitu TKP Senopati, Abu Bakar Ali, dan Ngabean. Dalam rangka mengusung perwujudan program </span><span>Sustainable Development Goals</span><span>, maka peneliti melakukan penelitian dengan menyimulasikan beberapa konsep </span><span>green tourism</span><span> yang berfokus pada sisi transportasi berupa pemindahan area parkir bus pariwisata dari Kawasan Malioboro ke Terminal Giwangan dan perencanaan mobilitas wisatawan dari dan ke Terminal Giwangan - Kawasan Malioboro. Tujuan dari penelitian ini adalah untuk mengidentifikasi kinerja lalu lintas saat ini di Kawasan Malioboro, merencanakan moda transportasi berbasis listrik di Kawasan Malioboro, mengintegrasikan mobilitas wisatawan dari area parkir dengan pilihan moda tradisional sebagai bentuk pelestarian kearifan lokal, serta mengidentifikasi perubahan kinerja lalu lintas dengan adanya rencana penerapan konsep </span><span>green tourism</span><span> di Kawasan Malioboro. Penelitian ini menggunakan pendekatan kuantitatif dengan menganalisis usulan konsep </span><span>green tourism</span><span> di bidang transportasi antara lain terkait kinerja ruas jalan dan persimpangan wilayah kajian saat ini, perencanaan kebutuhan dan jenis moda transportasi berbasis listrik, perencanaan integrasi area parkir dengan moda tradisional, dan perubahan kinerja lalu lintas terhadap konsep usulan di Kawasan Malioboro. Hasil analisis terhadap simulasi penerapan konsep </span><span>green tourism</span><span> di Kawasan Malioboro menunjukkan adanya rata-rata penurunan volume kendaraan pada ruas jalan di area kajian sebesar 28%, pada persimpangan sebanyak 15%, serta rata-rata penurunan emisi Karbon Monoksida (CO) kendaraan sebesar 25%. </span></span></p><p> </p><p> </p>
CLIMATE CHANGE MITIGATION HADIṠ PERSPECTIVE: Thematic-Correlative Approach
Authors: Azhari Ainul 
Published: February 2025

<p>Climate change is a critical issue threatening life on earth, requiring active human efforts and support from religion to address it. This study analyzes the moral messages in hadiṡ related to climate change mitigation through a thematic-correlative approach. This research uses qualitative methods, library research, and takhrij al-hadis, data were examined using content analysis, al-jarh wa al-ta’dil, and tawarikh al-ruwat, along with internal and external hadīṡ criticism. The findings confirm that three hadīṡs addressing climate change mitigation are of high quality, making them valid references for Islamic teachings (maqbūl al-hujjah) and applicable in practice. Thematically, these hadīṡ align with efforts to combat climate change, emphasizing the importance of preserving water resources and preventing ecosystem damage. Islam highlights water conservation and responsible usage, recognizing water as vital for all living beings. Mitigation efforts include reforestation, rehabilitating degraded lands, and prohibiting the felling of wild trees to sustain ecosystems. These teachings affirm Islam’s proactive approach to environmental preservation through hadis, advocating for sustainable practices that align with the broader goal of mitigating climate change impacts.</p><p> </p><p>[Perubahan iklim adalam masalah krusial yang mengancam kehidupan di bumi, membutuhkan upaya aktif manusia dan dukungan agama untuk mengatasinya. Penelitian ini menganalisis pesan moral dalam hadis yang berkaitan dengan mitigasi perubahan iklim melalui pendekatan tematik-korelatif. Penelitian ini menggunakan metode kualitatif, penelitian kepustakaan, dan takhrij al-hadits. Teknik analisis data menggunakan analisis isi, al-jarh wa al-ta’dil, dan tawarikh al-ruwat, serta kritik hadis dari aspek internal dan eksternal. Hasil penelitian ini menunjukkan bahwa tiga hadis yang membahas mitigasi perubahan iklim memiliki kualitas tinggi, sehingga dapat dijadikan referensi yang sah dalam ajaran Islam (maqbūl al-hujjah) dan diterapkan dalam praktik. Secara tematik, hadis-hadis ini sejalan dengan upaya mengatasi perubahan iklim, menekankan pentingnya menjaga sumber daya air dan mencegah kerusakan ekosistem. Islam menekankan konservasi air dan penggunaannya secara bijak, mengingat air adalah kebutuhan esensial bagi semua makhluk hidup. Upaya mitigasi meliputi reboisasi, rehabilitasi lahan yang terdegradasi, dan larangan penebangan pohon liar untuk menjaga keberlanjutan ekosistem. Ajaran ini menegaskan pendekatan proaktif Islam melalui hadis terhadap pelestarian lingkungan, mendorong praktik berkelanjutan yang sejalan dengan tujuan mitigasi dampak perubahan Iklim.]</p>
REINTERPRETATION OF THE HADITH ON RECYCLED WATER WITH A SCIENTIFIC APPROACH
Authors: Syukron Tubagus Muhammad , Fudhaili Ahmad 
Published: February 2025

<p>The hadith concerning the well of Budhāʻah, known for its contaminated condition, raises intriguing questions regarding Prophet Muhammad’s use of its water for ablution. The contradiction between the well’s description and the prophet’s action has prompted scholarly interpretations about a possible natural purification process. However, existing explanations regarding this purification do not fully align with the well’s condition as described in the hadith. This study reinterprets the Budhāʻah well hadith to determine the legal status of recycled water using modern scientific findings. Collaborating with PT Rofis Jaya Perkasa, a wastewater treatment company, this research aims to scientifically reconstruct the well’s historical condition. Employing a qualitative approach with a case study on the Budhāʻah well hadith, this research gathers data through literature review, interviews, and field observations. Hadith analysis involves scrutiny of its chain of sanad, matan, and contextual understanding using scientific theories. The analysis reveals that the well’s water was a mixture of rainwater and periodically entering household wastewater. Natural mechanisms, including microbial activity, were capable of transforming the contaminated water into cleaner water. These findings offer a new perspective on the concept of water purity in Islam, particularly concerning recycled water and its relevance to modern water treatment practices.</p><p> </p><p>[Hadis tentang Sumur Budhāʻah, yang dikenal karena kondisinya yang tercemar, menimbulkan pertanyaan menarik terkait penggunaan airnya oleh Nabi Muhammad untuk berwudu. Kontradiksi antara deskripsi sumur dan tindakan Nabi memunculkan interpretasi ulama tentang kemungkinan adanya proses semacam daur ulang. Kendati demikian, penjelasan mengenai proses penyucian air ini tidak sesuai dengan kondisi Sumur Budhāʻah sebagaimana yang termaktub dalam hadis. Penelitian ini akan menginterpretasi ulang hadis Sumur Budhāʻah dalam menentukan status hukum air daur ulang menggunakan pendekatan temuan sains modern. Melalui kolaborasi dengan PT Rofis Jaya Perkasa, sebuah perusahaan yang bergerak di bidang pengolahan air limbah, penelitian ini berusaha merekonstruksi secara ilmiah kondisi Sumur Budhāʻah pada masa lalu. Penelitian ini menggunakan pendekatan kualitatif dengan studi kasus pada hadis Sumur Budhā‘ah. Metode pengumpulan data meliputi studi pustaka, wawancara, dan observasi lapangan. Hadis akan ditinjau menggunakan kritik sanad, kritik matan, dan pemahaman hadis kontekstual dengan pendekatan teori sains. Hasil analisis menunjukkan bahwa air di Sumur Budhāʻah merupakan campuran air hujan dan limbah rumah tangga yang masuk berkala. Mekanisme alami, termasuk aktivitas mikroorganisme, mampu mengubah kualitas air yang tercemar menjadi air yang lebih bersih. Temuan ini membuka perspektif baru dalam memahami konsep kesucian air dalam Islam, khususnya terkait dengan air hasil daur ulang.]</p>
A clinical drug candidate that triggers non-apoptotic cancer cell death
Authors: Dixon Scott , Leak Logan , Wang Ziwei , Lee Weaverly Colleen , Johnson Brianna , Millner Alec , Ko Pin-Joe , Decosto Cassandra , Magtanong Leslie , Ritho Joan , Skouta Rachid , Atilla-Gokcumen Ekin , Myers Chad , Moffat Jason , Boone Charles , Bensinger Steven , Moding Everett , Joseph Alby , Chan Alyssa , Chitkara Shweta , Salinas Jenny , Nathanson David 
Published: February 2025

Abstract

Small molecules that induce non-apoptotic cell death are of fundamental mechanistic interest and may be useful to treat certain cancers. Here, we report that tegavivint, a drug candidate undergoing human clinical trials, can activate a unique mechanism of non-apoptotic cell death in sarcomas and other cancer cells. This lethal mechanism is distinct from ferroptosis, necroptosis and pyroptosis and requires the lipid metabolic enzyme trans-2,3-enoyl-CoA reductase (TECR). TECR is canonically involved in the synthesis of very long chain fatty acids but appears to promote non-apoptotic cell death in response to CIL56 and tegavivint via the synthesis of the saturated long-chain fatty acid palmitate. These findings outline a lipid-dependent non-apoptotic cell death mechanism that can be induced by a drug candidate currently being tested in humans.
The Changing Character of Chinese Urbanization: 2000 - 2021
Authors: Chen Wei-Qiang , Song Lulu , Lobo Jose , Bettencourt Luis 
Published: February 2025

Abstract

The scale and pace of urbanization in China over the past few decades is one of the most significant transformations of any human society in history. However, studying urbanization in China encounters an empirical difficulty common to many urban systems: Are there spatial units corresponding to cities as spaces of socioeconomic interaction? To address this question and analyze the transformation of Chinese cities and China’s urban system over the last few decades, we analyze a rich set of data comprising of 297 Chinese Prefecture-level Cities (PLCs) from 2000 to 2021. Our analysis fills a number of important gaps by carefully considering the difference in scaling effects result from using total versus registered population, and full PLCs definitions compared to their restriction to Urban Districts (UDs). Our results show that PLCs as well as their UDs exhibit scaling effects when measured with resident population. PLCs have become better urban units of analysis, characterizing functional cities in similar ways to other urban systems, especially after 2015. Their scaling exponents for GDP are also somewhat closer to theory than those obtained in UDs. The substantial redistribution of the population, with a growing concentration in larger and coastal cities and urban districts resulting in the scaling behavior. The future of Chinese urbanization is that these trends will intensify, leading to continued stronger growth of larger cities and relative population decline of many small and more rural places.
Examining the interplay between air pollution, surface vegetation cover, and stroke prevalence in East Africa: An ecological perspective
Authors: Baharane Valérien , Borisovich Shatalov Andrey , Larionov Maxim Viktorovich , Igwe Emmanuel 
Published: February 2025

Abstract

This study examines the impact of PM2.5, SO2, O3, CO, and surface greenness on stroke-related mortality rates in East Africa. Results showed a positive correlation between air pollutants of PM2.5 and SO2 with stroke prevalence, and a negative association between Enhanced Vegetation Index (EVI) and stroke fatality prevalence. The linear regression model showed that an increase of 10% in EVI could lead to the reduction of stroke-related deaths by 845.57 ± 295.96 deaths per 100,000 persons. Also, a 1 µg/m3 increase of PM2.5 and SO2 concentrations predicted a corresponding increase of stroke-related death by 3.06 ± 1.25 and 139.28 ± 64.33 deaths per 100,000 persons, respectively. Furthermore, the analysis of the influence of these environmental variables on the prevalence of mortality attributable to stroke by age groups showed its rise with age, both in intensity and statistical significance. For instance, a rise of 10% in EVI predicted the reduction of the stroke-related death rate by 9.18 ± 6.45 and 2133.93 ± 701.07 deaths per 100,000 persons in the age groups of 20–29 and 70–79 years old, respectively. A rise in 1 µg/m3 of PM2.5 and SO2 is expected to trigger the mortality incident rise from 0.05 ± 0.03 to 7.77 ± 3.01 and 4.28 ± 1.40 to 426.21 ± 152.38 deaths per 100,000 persons in respective age groups of 20–29 and 70–79 years. The exposure to CO and O3 did not demonstrate a significant effect on the stroke-related death rate in the region for the period of the study.
SUANPAN: Scalable Photonic Linear Vector Machine
Authors: Feng Xue , Yang Ziyue , Li Chen , Ran Yuqia , Li Yongzhuo , Cui Kaiyu , Liu Fang , Sun Hao , Zhang Wei , Ye Yu , Qiao Fei , Wang Jiaxing , Ning Cun-Zheng , J.Chang-Hasnain Connie , Huang Yidong 
Published: February 2025

Abstract

Photonics is promising to handle extensive vector multiplications in artificial intelligence (AI) techniques due to natural bosonic parallelism and high-speed information transmission. However, the dimensionality of current photonic linear operation is limited and tough to improve due to the complex beam-interaction for implementing optical matrix operation and digital-analog conversions. Here, we propose a programmable and reconfigurable photonic linear vector machine with extreme scalability formed by a series of emitter-detector pairs as the independent basic computing units. The elemental values of two high-dimensional vectors are prepared on emitter-detector pairs by bit encoding and analog detecting method without requiring large-scale analog-to-digital converter or digital-to-analog converter arrays. Since there is no interaction among light beams inside, extreme scalability could be achieved by simply multiplicating the independent emitter-detector pair. The proposed architecture is inspired by the traditional Chinese Suanpan or abacus, and thus is denoted as photonic SUANPAN. Experimentally, the computing fidelities for vector inner products could achieve > 98% in our implemented SUANPAN with an 8×8 vertical cavity surface emission laser (VCSEL) array and an 8×8 MoTe2 two-dimensional material photodetector array. Furthermore, SUANPAN is applied on two typical AI tasks as 1024-dimensional optimization problem is successfully solved and competitive classification accuracy of 88% is achieved for handwritten digit dataset. We believe that the photonic SUANPAN could serve as a fundamental linear vector machine and enhance various future AI applications.
Clot formation, structure, and fibrinolysis of pancreatic cancer patients
Authors: Risman Rebecca A , Milman Noam , Sinan Hajer , Tutwiler Valerie 
Published: February 2025

Abstract

Background: Pancreatic cancer (PC) has the highest risk of venous thromboembolisms amongst all cancer types. If not degraded through a process known as fibrinolysis, thrombi will continue to restrict blood flow and the transport of nutrients to downstream organs, which can lead to heart attack or stroke. While PC patients are known to be hypercoagulable and thus have an elevated thrombosis risk, the mechanism behind this behavior is not fully understood.
Aims: We aimed to characterize alterations in clotting and fibrinolytic profiles in PC patients compared to healthy controls.
Methods: Human blood plasma was collected from PC patients and healthy donor controls following institutional review board approval. We used kinetic turbidity to define the rates/timing of blood clot formation/degradation. Confocal and scanning electron microscopy were used to probe the effect PC has on fibrin network structure. Concentrations of proteins for clotting/fibrinolytic pathways were measured using ELISAs.
Results: PC patients were hypercoagulable compared to healthy donors with heightened fibrinogen concentration. A subset of patients were hypofibrinolytic, while most had similar fibrinolytic profiles to healthy. A comprehensive analysis revealed that delayed lysis in this subset was only present in patients with diabetes and/or COVID-19 due delayed clotting and, notably, elevated plasminogen activator inhibitor (PAI-1). In the general PC population, an extended PTT correlated with thicker fiber diameters while faster clotting resulted in smaller network pore size but was not correlated with lysis rate. Healthy, pooled plasma spiked with relevant concentrations of PAI-1 showed no difference in clot structure and comparable delays in lysis to patients.
Conclusion: PAI-1, rather than network structure or other clotting/fibrinolytic factors, played a more significant role in hypofibrinolysis. PAI-1 inhibitors could be a prospective target for development of improved therapeutics to prevent restricted fibrinolysis.
How Interaction with Parents Affects Children's Mathematical Informal Learning and Verbal Skills
Authors: Lee Na-Eun , Sarkar Biswajit 
Published: February 2025

Abstract

Informal learning, characterized by unstructured, incidental, and everyday learning activities, shapes children's academic performance. This study leverages the Early Childhood Longitudinal Study, ECLS-K dataset, a nationally representative sample of U.S. kindergartners, to examine the relationship between parental engagement in informal learning activities and children's academic accomplishment. This study utilized data visualization to investigate tendencies of children’s scores based on each demographic and interaction factor. Further, the study attempts to apply XB-Boost which can analyze large-scale data and uncover complex, non-linear relationships. This study explores the potential of using AI methods to identify contributions of parental interaction with their children and demographic factors.
Papillary Thyroid Carcinoma Originated in Thyroglossal Duct Cyst: Case Report
Authors: García-Cabra Damaris Areli , Ortega-Roman Oscar Alejandro , Carreón-Nava Karla Pamela , Juan Erick Rueda-Don 
Published: February 2025

Abstract

Purpose: The Thyroglossal Duct Cyst (TDC) is the most prevalent congenital developmental anomaly in the neck, nevertheless, papillary carcinoma emerging from thyroglossal cyst (TGDC) represents an exceptional finding, and the associated appearance with Papillary Thyroid Carcinoma (PTC) is even more uncommon. The clinical presentation is usually almost identical from a benign lesion and the postoperative histopathological study defines the diagnosis. However, its surgical management and follow-up is still debatable because there is no standard consensus for this. The aim of this work is to describe a case of papillary thyroid carcinoma which arise in a histopathological confirmed thyroglossal duct cyst, associated with papillary thyroid carcinoma of different histological variant, an infrequent condition.
Methods and Results: This is a case report of papillary thyroid carcinoma emerging from thyroglossal duct cyst, with clinical and imaging attribute of thyroglossal duct cyst, offering surgical management with Sistrunk Procedure (SP) with histopathological result of classical variant of PTC, with invasion to capsule wall. Cabinet tests in the absence of abnormal anatomical findings in thyroid gland, being considered an aspirant for total thyroidectomy (TT) in a second stage, with result of follicular variant of PTC.
Conclusion: TGDC is unusual and is commonly detected after surgery. Due to its almost indistinguishable presentation from benign pathology, it constitutes a defiance for the surgeon, being SP the first therapeutic step, in some cases it is fulfill with TT and ablative therapy with radioiodine, nevertheless, there are no systematize recommendations concerning to the surgical therapeutic outcome and its follow-up.
Design, construction, and deployment of a multi-locus transcranial magnetic stimulation system for clinical use
Authors: Sinisalo Heikki , Kahilakoski Olli-Pekka , Souza Victor H. , Nieminen Jaakko O. , Rantala Robin , Tommila Timo , Usuga Isabel , Laine Mikael , Ahola Oskari , Gallegos Eva , Kozák Gábor , Vetter David Emanuel , Rissanen Ilkka , Jooß Andreas , Matsuda Renan , Soto Ana M. , Li Dezhou , Humaidan Dania , Stenroos Matti , Roine Timo , Kičić Dubravko , Ziemann Ulf , Ilmoniemi Risto J. 
Published: February 2025

Abstract

Background:Transcranial magnetic stimulation (TMS) is an established method for noninvasive brain stimulation, used for investigating and treating brain disorders. Recently, multi-locus TMS (mTMS) has expanded the capabilities of TMS by employing an array of overlapping stimulation coils, enabling delivery of stimulation pulses at different cortical locations without physical coil movement. We aimed to design, construct, and deploy an mTMS device and a five-coil array for clinical environment, emphasizing safety of the system.
Methods: Our mTMS device is controlled by a field-programmable gate array (FPGA). The power electronics comprises five stimulation channels, each consisting of a high-voltage capacitor connected to a pulse circuit, controlling a single coil in the array. The device contains custom-designed circuit boards, with functions such as monitoring the system state, reporting errors, and delivering pulses. Our design utilizes redundancy in both hardware and firmware to ensure robust operation and safety. We performed an automated motor mapping test to verify the electronic targeting capabilities of the device.
Results: We constructed the mTMS device and deployed it to the Hertie Institute for Clinical Brain Research (Tübingen, Germany). Compared to our earlier prototype, the new design improves patient and operator safety. The motor mapping test confirmed that our device can accurately target stimulation pulses in the cortex.
Significance:mTMS or other similar technologies are currently not available for hospital use. The present device and its installation are major steps toward establishing multicoil TMS as an accessible clinical tool for investigation and treatment of the brain.
Experimental investigation of effects of nano-fluid usage on cooling in machining
Authors: BİLEN Kemal , KIZILKAYA Hakan Zafer , GÜLDAŞ Abdulmecit 
Published: February 2025

Abstract

Usage of nano-fluids in machining is gaining popularity due to their improved thermo-physical properties. Studies show that adding nano-particles like Al2O3, MWCNT or TiO2 to fluids enhances their density, viscosity, and thermal conductivity. This experimental study examines the effects of adding these nano-particles in concentrations of 0.5%, 1%, and 1.5% to the boron oil-water mixture. This study was conducted in three stages: preparation of nano-fluids, measurement of their thermo-physical properties, and machining experiments with Ti-6Al-4V material. The findings of the study revealed that while increasing nano-particles concentration consistently raised the fluid density at 24.5°C but it did not have similar effect on dynamic viscosity and thermal conductivity, which decreased after 1% concentration due to non-conformity of fluid form such as precipitation and sedimentation. Moreover, using nano-fluids reduced tool-workpiece interface temperature notably. Adding MWCNT nano-particle with the concentration of 0.5% reduced the cutting tool-workpiece interface temperature by about 18%. However, higher concentrations led to increasing in interface temperature and deteriorating in surface roughness because of deposit formation. Using MWCNT nano-particle with the concentration of 0.5% improved surface roughness by approximately 25%. The study concluded that nano-fluids provide desired machining improvements only at optimal concentrations, while excessive nano-particle concentrations fail to obtain the expected benefits thanks to SEM images of used cutting inserts.