bluuebunny/crossref_metadata_2025_split huggingface dataset:
Percutaneous treatment of facial venous malformations: A matched comparison of alcohol and bleomycin sclerotherapy
Authors: Spence Jessica , Krings Timo , TerBrugge Karel G. , Agid Ronit 
Published: April 2010

AbstractBackgroundVenous malformations (VMs) are common vascular anomalies; 40% are found in the head and neck. Percutaneous sclerotherapy is 1 treatment of choice.MethodsIn all, 17 patients with facial VMs were treated by percutaneous sclerotherapy using alcohol and individually matched to lesions treated with bleomycin. Treatment details and outcomes were compared. The average numbers of sessions were 1.7 for alcohol and 3.4 for bleomycin. Average dose administered was 8.1 cm3 alcohol and 9.1 units bleomycin.ResultsOf those treated with alcohol, 2 developed adverse effects and 7 developed complications. None treated with bleomycin developed adverse effects or complications. All patients treated with alcohol improved clinically. In all, 15 patients treated with bleomycin improved after treatment and 2 were unchanged.ConclusionsAlcohol has a slightly higher success rate and requires fewer treatment sessions. Bleomycin has a lower complication rate and less postprocedural swelling. Bleomycin treatment may be better tolerated and is thus preferred over alcohol sclerotherapy. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Genomic profiling of sinonasal squamous cell carcinoma
Authors: López Fernando , Llorente José L. , García‐Inclán Cristina , Alonso‐Guervós Marta , Cuesta‐Albalad Mari Paz , Fresno Manuel Florentino , Álvarez‐Marcos César , Suárez Carlos , Hermsen Mario A. 
Published: April 2010

AbstractBackgroundSinonasal squamous cell carcinomas (SCCs) are rare tumors with no etiologic link to tobacco and alcohol, as opposed to other SCCs of the head and neck (HNSCC). Little is known about the genetic changes in sinonasal SCC.MethodsDNA copy number changes of sinonasal SCC were analyzed by multiplex ligation‐dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features.ResultsCopy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11–q13.ConclusionThe genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Association between bisphosphonates and jaw osteonecrosis: A study in Wistar rats
Authors: Maahs Marcia P. , Azambuja Alan A. , Campos Maria M. , Salum Fernanda G. , Cherubini Karen 
Published: April 2010

AbstractBackgroundThis work aimed at determining whether bisphosphonate therapy produces a sufficient condition for jaw osteonecrosis after tooth extraction.MethodsRats were allocated into 3 groups: (1) 11 rats treated with alendronate, (2) 10 rats treated with zoledronic acid, and (3) 10 control rats. The animals were subjected to tooth extractions, and at the end of bisphosphonate therapy, they were humanely killed. Histologic sections of the surgical site were processed and analyzed.ResultsThe zoledronic acid group showed higher incidences of osteonecrosis, inflammatory infiltrate, and microorganisms. There was no significant difference for epithelial or connective tissue, root fragments, vital bone, and positive staining for vascular endothelial growth factor (VEGF) among the groups.ConclusionZoledronic acid is associated with jaw osteonecrosis, whereas alendronate did not produce a condition sufficient for osteonecrosis after tooth extraction. Neither zoledronic acid nor alendronate was associated with a reduced immunohistochemical expression of VEGF in vital bone at the tooth extraction site. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Meeting the challenge of identifying persistent pollutants at the state level
Authors: Hope Bruce K , Stone David , Fuji Taku , Gensemer Robert W , Jenkins Jeffrey 
Published: April 2010

Abstract
In 2007, the State of Oregon enacted legislation aimed at identifying persistent pollutants that could pose a threat to waters of the State and then reducing their discharge by means of a comprehensive pollution prevention program. This legislation defined a persistent pollutant as one that is toxic and persistent or bioaccumulative; a broad definition that required evaluation of an extensive number and variety of chemicals. The Oregon Department of Environmental Quality, in consultation with a science workgroup, implemented a 12-step process for identifying and prioritizing persistent pollutants consistent with this definition. This process is characterized by (a) maximum overall transparency in its conduct, including extensive public involvement, (b) 3 levels of objective and predefined criteria for categorization of a chemical as a persistent pollutant, (c) full disclosure of values and sources for all physicochemical data used for comparison with these criteria, and (d) clear acknowledgement when a chemical was identified as a persistent pollutant for reasons other than these criteria alone. This process was used to identify those chemicals relevant as persistent pollutants and to then prioritize them in terms of their relative ability to adversely impact waters of the state, with special emphasis on impacts to aquatic receptors. An initial list of 2130 chemicals was compiled from existing lists. Criteria for toxicity, persistence, and bioaccumulative potential were defined and then used with 2 different chemical property evaluation models (PBT Profiler and EPISuite) to produce a final list of 118 chemicals. The final list includes several legacy pollutants but also contains numerous current-use pharmaceuticals, personal care products, and pesticides, approximately half of which appear only once or not at all on lists compiled by others. Although it drew from the experience of others, assembling this list proved to be an exemplar of science in the service of policy. Integr Environ Assess Manag 2010;6:735–748. © 2010 SETAC
Acute atrazine exposure disrupts matrix metalloproteinases and retinoid signaling during organ morphogenesis in Xenopus laevis
Authors: Lenkowski Jenny R. , McLaughlin Kelly A. 
Published: April 2010

AbstractExposure to the herbicide atrazine disrupts many developmental processes in non‐target animals. Atrazine exposure during organ morphogenesis in amphibians results in dramatic malformations; the mechanism by which this happens has not been described. We have taken a candidate gene approach to explore two possible mechanisms by which acute atrazine exposure causes extensive malformations in several tissues in Xenopus laevis tadpoles. Using a static renewal system, we exposed tadpoles to atrazine for 6–48 h during organ morphogenesis (Nieuwkoop and Faber stage 42). We observed degradation of cranial cartilage and differentiated muscle in the head, gut and somites of exposed tadpoles. Additionally, transcript levels of matrix metalloproteinases (MMPs), specifically both MMP9TH and MMP18, increased in atrazine‐exposed tadpoles in a dose–response test, and MMP18 increased as early as 6 h after exposure began. Gelatinase MMP activity was also altered by atrazine exposure, indicating that atrazine disrupts gene function at the level of transcription and protein activity. Furthermore, transcript levels of the enzyme Xcyp26, an enzyme in the retinoic acid signaling pathway, significantly decreased in the intestines of tadpoles exposed to 10 or 35 mg l−1 atrazine for 48 h. Our results suggest two mechanisms by which atrazine can disrupt tissue morphogenesis: through misregulation of MMPs that are critical in extracellular matrix remodeling throughout development and the disruption of retinoic acid signaling. This study begins to describe conserved vertebrate developmental processes that are disrupted by atrazine exposure. Copyright © 2010 John Wiley & Sons, Ltd.
Effects of orthopedic polymer particles on chemotaxis of macrophages and mesenchymal stem cells
Authors: Huang Zhinong , Ma Ting , Ren Pei‐Gen , Smith R. Lane , Goodman Stuart B. 
Published: April 2010

AbstractWear particles generated from total joint arthroplasty (TJA) stimulate macrophages to release chemokines. The role of chemokines released from wear particle‐stimulated macrophages on the migration of macrophages and osteoprogenitor cells in vitro has not been elucidated. In this study, we challenged murine macrophages (RAW 264.7) with clinically relevant polymethyl methacrylate (PMMA, 1‐10 μm) and ultra high molecular weight polyethylene (UHMWPE, 2‐3 μm) particles. The chemotactic effects of the conditioned media (CM) were tested in vitro using human macrophages (THP‐1) and human mesenchymal stem cells (MSCs) as the migrating cells. CM collected from both particle types had a chemotactic effect on human macrophages, which could be eliminated by monocyte chemotactic protein‐1 (MCP‐1) neutralizing antibody. Blocking the CCR1 receptor eliminated the chemotactic effect, while CCR2 antibody only partially decreased THP‐1 cell migration. CM from PMMA but not UHMWPE‐exposed macrophages led to chemotaxis of MSCs; this effect could be eliminated by macrophage inflammatory protein‐1 alpha (MIP‐1α) neutralizing antibody. Neither CCR1 nor CCR2 blocking antibodies showed an effect on the migration of MSCs. Chemokines released by macrophages stimulated by wear particles can have an effect on the migration of macrophages and MSCs. This effect seems to be dependent on the particle type, and may be modulated by MCP‐1 and MIP‐1α, however, more than one chemokine may be necessary for chemotaxis. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.
PML down‐regulation in soft tissue sarcomas
Authors: Vincenzi Bruno , Perrone Giuseppe , Santini Daniele , Grosso Federica , Silletta Marianna , Frezza Annamaria , Rossi Sabrina , Russo Antonio , Rabitti Carla , Gebbia Nicola , Badalamenti Giuseppe , Casali Paolo , Muda Andrea Onetti , dei Tos Angelo Paolo , Tonini Giuseppe 
Published: April 2010

AbstractTo date, little is known concerning the promyelocytic leukemia gene (PML) status in tumors of different origin, and its expression has never been evaluated in soft tissue sarcoma. The aim of the present study is focused on the identification of differences in terms of PML protein expression between different types of soft tissue sarcoma and the corresponding normal surrounding tissue. PML protein expression has been assessed by immunohistochemistry in six different histologic types of soft tissue sarcoma (synovial sarcoma, myofibroblastic sarcoma, angiosarcoma, liposarcoma, pleomorphic sarcoma, and leiomyosarcoma) and in the corresponding normal surrounding tissue. PML resulted significantly down‐regulated in synovial sarcoma and in myofibroblastic sarcoma specimens. Also in angiosarcoma samples a significative difference in PML expression in comparison with normal specimens has been detected. Interestingly PML protein detection showed a different pattern of expression in the three liposarcoma histology types compared with corresponding nontumoral tissues. In particular PML protein resulted significantly down‐regulated in myxoid liposarcoma and in dedifferentiated liposarcoma. On the contrary no statistically significant difference was observed in pleomorphic liposarcoma compared to normal tissue specimens. Further investigations are needed to confirm these data and to assess the possible value of PML expression as a prognostic factor in these extremely aggressive diseases. J. Cell. Physiol. 224: 644–648, 2010. © 2010 Wiley‐Liss, Inc.
Eco‐friendly, solvent‐free novel one‐pot, three‐component synthesis of quinazolinones at ambient temperature catalyzed by silica gel‐supported phosphomolybdic acid
Authors: Sabitha Gowravaram , Reddy N. Mallikarjuna , Prasad M. Nagendra , Raja G. S. K. , Yadav J. S. 
Published: April 2010

Abstract
magnified image Silica gel supported Phosphomolybdic acid (PMA.SiO2) catalyzes efficiently the one‐pot three‐component coupling reaction of anthranilic acid, orthoesters, and amines at room temperature to afford 4(3H)‐Quinazolinones in high to excellent yields under solvent‐free conditions. The supported catalyst can be recovered and reused. J. Heterocyclic Chem., (2010).
A facile automated synthesis of N‐succinimidyl 4‐[18F]fluorobenzoate ([18F]SFB) for 18F‐labeled cell‐penetrating peptide as PET tracer
Authors: Tang Ganghua , Tang Xiaolan , Wang Xinlu 
Published: April 2010

AbstractA fully automated synthesis of N‐succinimidyl 4‐[18F]fluorobenzoate ([18F]SFB) was carried out by a convenient three‐step, one‐pot procedure on the modified TRACERlab FXFN synthesizer, including [18F]fluorination of ethyl 4‐(trimethylammonium triflate)benzoate as the precursor, saponification of the ethyl 4‐[18F]fluorobenzoate with aqueous tetrapropylammonium hydroxide instead of sodium hydroxide, and conversion of 4‐[18F]fluorobenzoate salt ([18F]FBA) to [18F]SFB treated with N,N,N′,N′‐tetramethyl‐O‐(N‐succinimidyl)uranium tetrafluoroborate (TSTU). The purified [18F]SFB was used for the labeling of Tat membrane‐penetrating peptide (containing the Arg‐Lys‐Lys‐Arg‐Arg‐Arg‐Arg‐Arg‐Arg‐Arg‐Arg‐Pro‐Leu‐Gly‐Leu‐Ala‐Gly‐Glu‐Glu‐Glu‐Glu‐Glu‐Glu‐Glu sequence, [18F]CPP) through radiofluorination of lysine amino groups. The uncorrected radiochemical yields of [18F]SFB were as high as 25–35% (based on [18F]fluoride) (n=10) with a synthesis time of∼40 min. [18F]CPP was produced in an uncorrected radiochemical yields of 10–20% (n=5) within 30 min (based on [18F]SFB). The radiochemical purities of [18F]SFB and [18F]CPP were greater than 95%. Copyright © 2010 John Wiley & Sons, Ltd.
The identification of synthetic homopolymer end groups and verification of their transformations using MALDI‐TOF mass spectrometry
Authors: Li Yejia , Hoskins Jessica N. , Sreerama Subramanya G. , Grayson Michael A. , Grayson Scott M. 
Published: April 2010

AbstractRecent advances in the resolving power of matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) enable the detailed characterization of linear homopolymers, and in particular provide invaluable data for the determination of their end‐group functionalities. With the growing importance of macromolecular coupling reactions in building complex polymer architectures, the ability to accurately monitor end‐group transformations is becoming increasingly important for synthetic polymer chemists. This tutorial demonstrates the application of MALDI‐TOF MS in determining both end‐group functionalities and their transformations for linear homopolymers. Examples of both polycaprolactone and polystyrene are examined, and the strengths and weaknesses of various approaches to data analysis are given. Copyright © 2010 John Wiley & Sons, Ltd.
Will snow‐abundant winters still exist in the Swiss Alps in an enhanced greenhouse climate?
Authors: Beniston Martin , Uhlmann Bastienne , Goyette Stéphane , Lopez‐Moreno Juan Ignacio 
Published: April 2010

AbstractSnow cover and duration are very variable components of the alpine environment and are often poorly reproduced in climate models. Using joint probability temperature/precipitation distributions to categorize cold/dry, cold/moist, warm/dry (WD) and warm/moist situations in winter, this study demonstrates that one particular mode (WD) exerts the strongest influence on snow. When the number of WD days is low, snow in the Swiss Alps is abundant, and vice versa. Since the 1950s, there has been an increase in the WD events and a subsequent reduction in snow cover. Snow‐abundant winters have nevertheless occurred in recent years, when WD days are low, despite winter temperatures that are more than 1 °C higher than those in the mid‐1900s. The WD mode thus represents a form of proxy to snow amount and duration; its evolution in an enhanced greenhouse climate can help identify whether snow‐abundant winters may still occur in a much warmer world. Copyright © 2010 Royal Meteorological Society
Oxidative stress in subsynovial connective tissue of idiopathic carpal tunnel syndrome
Authors: Kim Jae Kwang , Koh Young Do , Kim Jeong Suk , Hann Hoo Jae , Kim Mi Jin 
Published: April 2010

AbstractIschemic‐reperfusion injury is thought to be a cause of idiopathic carpal tunnel syndrome (CTS). The purpose of this study was to determine whether oxidative stress caused by ischemia‐reperfusion injury in subsynovial connective tissue is associated with idiopathic CTS and its symptoms. Bioptic samples of tenosynovial tissue were collected from 20 idiopathic CTS patients during surgery. Control specimens of tenosynovial tissue were collected from eight non‐CTS patients. Analysis included histological and immunohistochemical examination for the distribution of endothelial nitric oxide synthase (eNOS), nuclear factor (NF)‐κβ, and transforming growth factor (TGF)‐β RI in subsynovial connective tissues. Histological examinations showed a marked increase in fibroblast density and vascular proliferation in specimens from CTS patients. The expressions of eNOS, NF‐κβ, and TGF‐β RI in fibroblasts and vascular endothelial cells of subsynovial connective tissues of patients were significantly higher than in those of controls. A significant positive correlation was found between the subjective symptom severity of CTS, and the immunoreactivities of eNOS and NF‐κβ. This study suggests that oxidative stress in subsynovial connective tissue is related to CTS and its symptoms. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1463–1468, 2010
Plasma brominated polymer particles as grafting substrate for thiol‐terminated telomers
Authors: Byström Emil , Nordborg Anna , Limé Fredrik , Dinh Ngoc Phuoc , Irgum Knut 
Published: April 2010

AbstractA combined surface activation and “grafting to” strategy was developed to convert divinylbenzene particles into weak cation exchangers suitable for protein separation. The initial activation step was based on plasma modification with bromoform, which rendered the particles amenable to further reaction with nucleophiles by introducing Br to a surface content of 11.2 atom‐%, as determined by X‐ray photoelectron spectroscopy. Grafting of thiol‐terminated glydicyl methacrylate telomers to freshly plasma activated surfaces was accomplished without the use of added initiator, and the grafting was verified both by reduction in bromine content and the appearance of sulfur‐carbon linkages, showing that the surface grafts were covalently bonded. Following grafting the attached glydicyl methacrylate telomer tentacles were further modified by a two‐step procedure involving hydrolysis to 2,3‐hydroxypropyl groups and conversion of hydroxyl groups to carboxylate functionality by succinic anhydride. The final material was capable of baseline separating four model proteins in 3 min by gradient cation exchange chromatography in a fully aqueous eluent.
A Novel Route for Fabricating Metal‐Polymer Composite Nanoparticles with Phase‐Separated Structures
Authors: Yabu Hiroshi , Koike Kazutaka , Motoyoshi Kiwamu , Higuchi Takeshi , Shimomura Masatsugu 
Published: April 2010

AbstractAu nanoparticles (NPs) and polymer composite particles with phase‐separation structures were prepared based on phase separation structures. Au NPs were successfully synthesized in amphiphilic block‐copolymer micelles, and then composite particles were formed by a simple solvent evaporation process from Au NPs and polymer solution. The phase separated structures (Janus and Core‐shell) were controlled by changing the combination of polymers having differing hydrophobicity.magnified image
Tragfähigkeit von Aluminiumschrauben Teil 1 – Statische Tragfähigkeit
Authors: Arz U. , Weber J. O. , Marx T. , Berger C. 
Published: April 2010

AbstractDer vorliegende Beitrag gibt eine Übersicht über die statische Tragfähigkeit von hochfesten Aluminiumschrauben aus den Knetwerkstoffen EN AW 6056 und EN AW 7075, wobei am Rande noch Schrauben aus den Werkstoffen EN AW 6013 und EN AW 6082 betrachtet werden. Die zurzeit erreichbaren mechanischen und zyklischen Eigenschaften, sowie verschiedene Einflüsse hierauf werden beschrieben. In Teil 2 wird auf die zyklische Tragfähigkeit eingegangen.In this paper an overview of the mechanical behaviour of high strength screws made of aluminum is given. The investigated wrought alloys are AA 6056 and AA 7075. In some cases there is look to the wrought alloys AA 6013 and AA 6082. In part 2 a description of the cyclic behaviour of these alloys will be given.
New procedure for preparation of highly stable and well separated carbon nanotubes in an aqueous modified polyacrylonitrile
Authors: Bagheri B. , Abdouss M. , Shoushtari A. M. 
Published: April 2010

AbstractCarbon nanotubes (CNTs) due to their nonreactive surface can not effectively disperse in polymeric matrix. Efficient exploitation of CNTs properties to improve material performance is generally related to the degree of dispersion, saturation by the matrix and interfacial adhesion. In order to obtain a suitable dispersion, the CNTs usually need treatment before they can be utilized. In this work, an easy procedure for preparation a stable dispersion of well separated and individual CNTs in an aqueous polymeric solution by using of Gum Arabic (GA) and modified polymer has been described. The applied polymer was a modified water soluble acrylonitrile polymer. The modification was carried out through functionalizing polyacrylonitrile by 2‐aminoethanol. Individual dispersion of the CNTs in the aqueous GA solution after two month can be observed. By incorporating the modified polyacrylonitrile to the solution, the stability of the individual CNTs dispersion several times was increased in such a way that after six month, the CNTs were still kept at their individual positions. According to the suggested mechanism of dispersion, hydrogen bonds between GA/CNTs and the modified polyacrylonitrile chains can be formed that increasing the dispersion ability. The effects of salts and temperature on dispersion ability of GA were also studied.
Rapid harvesting both kidneys from one donor rat for transplantation with a technique of sharp dissection after irrigation
Authors: Daqiang Zhao , Jun Li , Jiang Qiu , Changxi Wang , Lizhong Chen 
Published: April 2010

AbstractThe comparisons of two different methods of donor nephrectomy were performed in this study. Fisher inbred rats were used as donors and recipients of kidneys. In method A (the conventional technique), meticulous blunt dissection of the abdominal aorta, inferior vena cava, and renal arteries/veins, was followed by ligating and cutting the superior mesenteric artery and small vessels entering the above vessels. Both donor kidneys were irrigated after the suprarenal aorta and inferior vena cava were cross‐clamped (n = 10). In method B, donor rats were systematically irrigated by infrarenal aorta catheterization following laparotomy, then the vessels were sharply mobilized using a pair of microscissors to directly cut the fat and adherent connective tissues away from the edge of the vessels (n = 10). Isotransplantation was performed by end‐to‐side anastomosis of the blood vessels and end‐to‐end anastomosis of the ureters. Irrigating the donor kidney before dissection provided a clear visual field, reduced the operation time (37.50 ± 6.84 versus 68.30 ± 11.53 minutes, p < 0.001), facilitated the dissection of vessels, and reduced the risk of vasospasm (5 out of 19 versus 0 out of 18, p < 0.05). This study has demonstrated the proposed technique is fast and safe, and may be useful in research of renal transplantation in the rat model. © 2010 Wiley‐Liss, Inc. Microsurgery 30:569–573, 2010.