bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the uterine bleeding profile in women using a subcutaneous contraceptive implant containing etonogestrel: Real-life clinical practice
Authors: Mezhevitinova E. A. , Prilepskaya V. N. , Kepsha M. A. , Ilyasova N. A. , Mgeryan A. N. , Dovletkhanova E. R. , Abakarova P. R. , Nazarova N. M. 
Published: May 2024

Introduction. Pregnancy planning is one of the leading areas in the population reproductive health care, in particular preventing and reducing the number of abortions.Aim. To evaluate the uterine bleeding profile and other adverse events associated with the use of an etonogestrel subcutaneous contraceptive implant (Implanon NXT®). Materials and methods. We analysed medical records of female patients (n = 153) who used Implanon NXT® in the period from 2013 to 2023, records of adverse events, uterine bleeding, bleeding management techniques and reasons given by women for discontinuing the use of implants.Results. The median duration of uterine bleeding episodes ranged from 7 to 13 days within a three-year period of use of Implanon NXT®. During the first 3 months, the proportion of women with prolonged bleeding was higher as compared to all other observation periods and gradually decreased during the first year of use of the drug from 41.2 to 15.8%. 40 patients with complaints of unsatisfactory uterine bleeding patterns required adjustment of drug dosages; 14 women continued to use Implanon NXT® after adjustment of drug dosages and repeated visits. 17.0% (n = 26) of patients required early removal of the implant. Due to pregnancy planning, the implant was removed early in 13% (n = 20) of patients. The most common adverse events included functional ovarian cysts, mastalgia, increased appetite, decreased libido, dizziness, acne; most of them were transient and did not require any management, and were not considered the reason for implant removal.Conclusion. The number of uterine bleeding episodes in patients using the etonogestrel implant was comparable to the normal menstrual cycle. Some women had changes in the uterine bleeding patterns, such as amenorrhea, frequent and prolonged bleeding, which reduced the duration of use of this contraception method. At the same time, combined oral contraceptives were the most effective as compared to other drugs used in correction regimens.
Pregravid preparation for women with bacterial vaginosis and a history of early pregnancy loss
Authors: Gerasimova O. P. , Solovyeva A. V. , Chegus L. A. , Vinokurova E. А. , Doronina O. K. , Spitsyna M. A. , Aleynikova E. Yu. , Rudenko D. B. 
Published: May 2024

Introduction. Statistics show that about 13 to 15 in 100 pregnancies end in early miscarriage. This represents both a medical and social issue, as such outcome may be associated with maternal depression and anxiety, which inevitably affects women’s activities, performance efficiency and social inclusion. Restoration of normobiocenosis and lactobacilli pool dominance is one of the key challenges for women planning pregnancy.Aim. To evaluate the effectiveness of probiotics at the pregravid preparation stage in women with a history of early pregnancy loss and bacterial vaginosis (BV).Materials and methods. We selected 46 patients of reproductive age (24–39 years) who applied for early pregnancy loss, with complaints of vaginal discharge with an unpleasant odour, pruritus, burning, and dyspareunia, using databases of 5 medical clinics in Moscow, Tyumen and Stavropol. To treat bacterial vaginosis, two-stage therapy aimed at eliminating the increased number of anaerobic microorganisms and restoring the vaginal microbiocenosis was used.Results. The effectiveness of combination therapy was assessed at 1 month. All patients on therapy experienced clinical improvement, normalization of vaginal microbiocenosis parameters based on Femoflor-16 test findings after the end of treatment. Physiological microbiocenosis of Lactobacillus spp. > 107 was detected in 43 (94.5%). In all patients, the average vaginal pH after two-stage therapy was 4.3 ± 0.7. The safety of Acilact Duo therapy was assessed in all study participants. No negative trends were recorded.Conclusion. Superlimflife (Acilact Duo), acidophilus bacteria + vitamin-mineral protein-peptide complex, quickly restores optimal vaginal acidity (pH), stimulates the growth of lactobacilli, and reduces the incidence of BV relapses.
Pregnancy outcomes and complications after renal transplantation
Authors: Kirsanova T. V. , Kravchenko N. F. , Piliya Z. A. , Khodzhaeva Z. S. , Fedorova T. A. , Rozina N. A. , Kolobov E. P. 
Published: May 2024

Introduction. Chronic kidney disease (CKD) in pregnancy poses certain risks of both gestational complications and adverse perinatal outcomes, which increase with the decline of renal function.Aim to access pregnancy outcomes in patients who underwent nephrotransplantation.Materials and methods. Retrospective study of pregnant women who gave birth at Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology in the period from 2005 to 2021: 102 pregnancies in 97 patients were analyzed: five recipients had two successful pregnancies.Results. The average age of pregnant women was 31 ± 4.03 years. In equal proportions, patients underwent related or cadaveric kidney transplantation – 52% (n = 53) and 48% (n = 49) of cases, respectively. The average delivery time was 35.5 ± 2.7 weeks. The average weight of newborns was 2545 ± 655 grams. Premature birth (PB) occurred in 47.1%, the average period of birth was 33.4 ± 2.87 weeks, of which early birth (<32 weeks) was 22.5%. The average period of pregnancy after transplantation was 5 ± 3.31 (1–18) years, this period was not associated with obstetric complications or deterioration of graft function. A significant increase in the following parameters was noted during pregnancy: serum creatinine level (p = 0.006), proteinuria (p = 0.003). The glomerular filtration rate also decreased significantly by the end of pregnancy (p = 0.011). Preeclampsia was the leading cause of decreased graft function during pregnancy (32.4%).Conclusions. In general, pregnancy outcomes after nephrotransplantation are favorable, but there is an increased risk of preeclampsia, preterm birth, including operative delivery, urinary tract infection and anemia.
Awareness Regarding Cancer Cachexia and its Nutritional Management Among Practising Dietetic Professionals in India
Authors: Eranpurwala Arwa , Gokhale Devaki 
Published: May 2024

Aim:
The present study aimed to investigate the awareness of practicing dietetic professionals
regarding the nutritional management of cancer cachexia

Background:
Due to the rising rates of cancer cachexia-related mortality, dietetic professionals
have taken on an essential role in identifying and managing its associated symptoms through nutrition
to reduce its escalating side effects.

Objective:
To assess knowledge and awareness of nutritional management of cancer cachexia and
understand the factors influencing them.

Methods:
This cross-sectional survey among dietetic professionals was conducted using an online
questionnaire. Both descriptive and parametric were used to analyze the data.

Results:
A total of 211 dietetic professionals were included in the study. Within the domain of
awareness, the participants who scored more than the median (> 3.5) scores were considered to
have good knowledge (36%, n= 76), and those less than the median (≤3.5) scores were considered
to have poor knowledge (64%, n=135). Notably, knowledge scores were significantly influenced
by the highest qualification attained (Ph.D. / Registered Dietitian), years of experience, the monthly
caseload of cancer patients, level of confidence, and adherence to evidence-based guidelines for
managing cancer cachectic patients (p-values all significant, ≤0.05). Dietetic Professionals suggested
knowledge upgradation, mandatory dietitian referrals, and team optimization, among other
strategies to raise awareness.

Conclusion:
A high rate of incorrect responses was observed, with most participants demonstrating
poor knowledge. Hence, there is an urgent need for training dietetic practitioners to improve
specific knowledge about cancer cachexia and develop expertise in its nutritional care through designing
different awareness programs.
Updated COVID-19 Pharmacotherapy in Different Diseases Such as Cancer
Authors: Tolou-Ghamari Zahra 
Published: May 2024

Background:
Studies suggest that cancer is a main complication regarding life expectancy
and a foremost reason for death worldwide. For the treatment of COVID-19 infected 703,525,337
cases with 6,984,801 deaths worldwide up to February 21, 2024, well-designed pharmacotherapy
management in different diseases, such as cancer, is respected. This investigation aims to review the
current accessible medical treatment for patients with different diseases, cancer, and COVID-19.

Methods:
The appropriate documents for this review were achieved by searching databases such as
Web of Science, Scopus, and PUBMED. Relevant studies included in review articles, clinical trials,
and case reports that were evaluated and used (n=109 articles).

Results:
In those with cancer and COVID-19, publications reported worsened clinical conditions
with a considerably higher risk of death. The result of existing regular antitumor management could
be a basis of debate. In the general population, asymptomatic patients with positive nasopharyngeal
swabs are recommended to receive antibiotic prophylaxis, and in those with symptomatic signs, adjustment
of angiotensin-converting enzyme based on anti-hypertensive therapy should be considered.
In patients with liver disease, nitazoxanide plus sofosbuvir, ivermectin, tocilizumab, convalescent
plasma, and low molecular weight heparin in certain situations is recommended. Furthermore, favipiravir,
chloroquine, and hydroxychloroquine could also be recommended, but with caution regarding
to polypharmacy interactions. For those with moderate disease, hydroxychloroquine or chloroquine/
azithromycin was recommended. In the patients with respiratory failure, convalescent plasma
was suggested. In the populations where those symptoms progress to the sign of a cytokine storm,
the antagonists of interleukin-6 (IL-6) were suggested. To reduce fever, however, ibuprofen showed
more potent efficacy compared to acetaminophen, but it may delay the benefits of a fever response.

Conclusion:
Owing to the immune suppression that could be caused by anti-cancer drugs and deterioration
of lung functions due to COVID-19, for proposed management regarding pharmacotherapy
strategies, further evidence-based studies seem to be advantageous.
Accuracy of the Apple Watch Series 4 and Fitbit Versa for Assessing Energy Expenditure and Heart Rate of Wheelchair Users During Treadmill Wheelchair Propulsion: Cross-sectional Study
Authors: Danielsson Marius Lyng , Vergeer Melanie , Plasqui Guy , Baumgart Julia Kathrin 
Published: May 2024

Background
The Apple Watch (AW) Series 1 provides energy expenditure (EE) for wheelchair users but was found to be inaccurate with an error of approximately 30%, and the corresponding error for heart rate (HR) provided by the Fitbit Charge 2 was approximately 10% to 20%. Improved accuracy of estimated EE and HR is expected with newer editions of these smart watches (SWs).

Objective
This study aims to assess the accuracy of the AW Series 4 (wheelchair-specific setting) and the Fitbit Versa (treadmill running mode) for estimating EE and HR during wheelchair propulsion at different intensities.

Methods
Data from 20 manual wheelchair users (male: n=11, female: n=9; body mass: mean 75, SD 19 kg) and 20 people without a disability (male: n=11, female: n=9; body mass: mean 75, SD 11 kg) were included. Three 4-minute wheelchair propulsion stages at increasing speed were performed on 3 separate test days (0.5%, 2.5%, or 5% incline), while EE and HR were collected by criterion devices and the AW or Fitbit. The mean absolute percentage error (MAPE) was used to indicate the absolute agreement between the criterion device and SWs for EE and HR. Additionally, linear mixed model analyses assessed the effect of exercise intensity, sex, and group on the SW error. Interclass correlation coefficients were used to assess relative agreement between criterion devices and SWs.

Results
The AW underestimated EE with MAPEs of 29.2% (SD 22%) in wheelchair users and 30% (SD 12%) in people without a disability. The Fitbit overestimated EE with MAPEs of 73.9% (SD 7%) in wheelchair users and 44.7% (SD 38%) in people without a disability. Both SWs underestimated HR. The device error for EE and HR increased with intensity for both SWs (all comparisons: P<.001), and the only significant difference between groups was found for HR in the AW (–5.27 beats/min for wheelchair users; P=.02). There was a significant effect of sex on the estimation error in EE, with worse accuracy for the AW (–0.69 kcal/min; P<.001) and better accuracy for the Fitbit (–2.08 kcal/min; P<.001) in female participants. For HR, sex differences were found only for the AW, with a smaller error in female participants (5.23 beats/min; P=.02). Interclass correlation coefficients showed poor to moderate relative agreement for both SWs apart from 2 stage-incline combinations (AW: 0.12-0.57 for EE and 0.11-0.86 for HR; Fitbit: 0.06-0.85 for EE and 0.03-0.29 for HR).

Conclusions
Neither the AW nor Fitbit were sufficiently accurate for estimating EE or HR during wheelchair propulsion. The AW underestimated EE and the Fitbit overestimated EE, and both SWs underestimated HR. Caution is hence required when using SWs as a tool for training intensity regulation and energy balance or imbalance in wheelchair users.
Pulmonary Tuberculosis Notification Rate Within Shenzhen, China, 2010-2019: Spatial-Temporal Analysis
Authors: Lai Peixuan , Cai Weicong , Qu Lin , Hong Chuangyue , Lin Kaihao , Tan Weiguo , Zhao Zhiguang 
Published: May 2024

Background
Pulmonary tuberculosis (PTB) is a chronic communicable disease of major public health and social concern. Although spatial-temporal analysis has been widely used to describe distribution characteristics and transmission patterns, few studies have revealed the changes in the small-scale clustering of PTB at the street level.

Objective
The aim of this study was to analyze the temporal and spatial distribution characteristics and clusters of PTB at the street level in the Shenzhen municipality of China to provide a reference for PTB prevention and control.

Methods
Data of reported PTB cases in Shenzhen from January 2010 to December 2019 were extracted from the China Information System for Disease Control and Prevention to describe the epidemiological characteristics. Time-series, spatial-autocorrelation, and spatial-temporal scanning analyses were performed to identify the spatial and temporal patterns and high-risk areas at the street level.

Results
A total of 58,122 PTB cases from 2010 to 2019 were notified in Shenzhen. The annual notification rate of PTB decreased significantly from 64.97 per 100,000 population in 2010 to 43.43 per 100,000 population in 2019. PTB cases exhibited seasonal variations with peaks in late spring and summer each year. The PTB notification rate was nonrandomly distributed and spatially clustered with a Moran I value of 0.134 (P=.02). One most-likely cluster and 10 secondary clusters were detected, and the most-likely clustering area was centered at Nanshan Street of Nanshan District covering 6 streets, with the clustering time spanning from January 2010 to November 2012.

Conclusions
This study identified seasonal patterns and spatial-temporal clusters of PTB cases at the street level in the Shenzhen municipality of China. Resources should be prioritized to the identified high-risk areas for PTB prevention and control.
Literature Spaces problematizations in Uma Jornada Como Tantas, of Francisco Dantas and Essa Gente, of Chico Buarque
Authors: Pinto Maria Gabriele Silva , Brito Herasmo Braga de Oliveira 
Published: May 2024

The aim of this study is to discuss aspects of Brazilian neoregionalism in contemporary literature, problematize the literary space based on Brazilian neoregionalism, which emerges as a new trend in literature, and finally analyze how fictional and subjective spaces are configured and singularized in neoregionalist works: Uma Jornada como Tantas (2019) by Francisco Dantas and Essa Gente (2019) by Chico Buarque. The research is categorized as bibliographic and is based on the theoretical perspective of the following authors: Braga (2017), Bachelard (1993), Ozíres (2007), Brandão (2013), and Tuan (2015). First, the necessary foundation was sought to characterize how fictional and subjective spaces directly influence the characters’ identity formation, influencing their emotions, decisions, conflicts, and constitutions. Next, na attempt was made to understand how the characters’ subjectivities are directly linked to the space in which they are inserted. Finally, analyses of spaces in neoregionalist works were conducted, meticulously observing their composition in the characters’ identity formation, as well as how they act not only in the physical environment but also in the narrative construction, since the space is constructed through dialogues among the characters, their memories, experiences, and subjectivities, characterizing a certain place based on their experiences.
Chemistry Learning Innovation in Household Level Entrepreneurship Product Training for The Community of Tidung Island
Authors: Simanjuntak Familia Novita , Simatupang Nova Irawati , Azzahra St Fatimah , Sumiyati Sumiyati , Harefa Nelius , Sormin Elferida , Purba Leony Sanga Lamsari 
Published: May 2024

This community service aims to provide support and training to PKK women on Tidung Island. Service implementation is carried out using presentations, interactive discussions, and direct practice to improve the village's capacity and creativity. The objectives to be achieved by this activity are to increase knowledge about the effects of careless disposal of used cooking oil waste and to improve skills in handling used cooking oil so that it is a valuable useful treatment. Used cooking oil is waste cooking oil that has been used many times and contains carcinogenic compounds that are difficult to decompose. Both of these properties are dangerous to health and the environment if used cooking oil is consumed and discharged into the environment without change. To achieve this goal, the method that will be used in this activity is to provide health education on the effects of careless disposal of used cooking oil waste and subsequent processing practices using cooking oil into candles. The outcome of undertaking this activity is an increased understanding of the impact of used cooking oil waste on health and the environment. In addition, you can also take advantage of used cooking oil scraps to make candles.
The Zinc-Copper Connection In Autism Spectrum Disorder: Pioneering Work Of Dr. Geir Bjørklund
Authors: Semenova Yuliya 
Published: May 2024

Abstract
This interview delves into the relationship between zinc (Zn) and copper (Cu) in autism spectrum disorder (ASD), featuring insights from Dr. Geir Bjørklund, MD, a Norwegian researcher. Collaborative studies conducted across diverse countries, including China, Slovenia, Romania, Russia, Brazil, and Egypt, consistently reveal altered Zn and Cu levels in individuals with ASD. These findings suggest a potential correlation between elevated Cu levels and increased severity of ASD symptoms. Dr. Bjørklund emphasizes the multifaceted dynamics of metallothioneins (MTs), essential proteins for metal binding and detoxification, and their potential association with Zn deficiency in ASD individuals. The interview illuminates the balance between Zn and Cu within the GABAergic system, implicating these trace elements in synaptic modulation and broader neurobiological functions. Future research directions proposed by Dr. Bjørklund encompass exploring multiple biological mediums for accurate trace element assessment, investigating interactions between different trace elements, and exploring factors influencing trace element levels in various tissues. The significance of Zn supplementation in treating ASD, the implications of MT dysfunction, and the importance of dual monitoring of Cu and Zn during therapy are thoroughly discussed. The conclusion expresses gratitude for Dr. Bjørklund’s invaluable contributions to comprehending the role of Zn and Cu in ASD, highlighting the global relevance of his research and the need for a comprehensive approach to understanding trace element dynamics in this complex neurodevelopmental disorder.
FAKTOR YANG MEMPENGARUHI PROFITABILITAS PERBANKAN DENGAN MENGGUNAKAN ECONOMIC VALUE ADDED BANK
Authors: Sharon Sharon , Salim Susanto 
Published: May 2024

The research that has been conducted aims to obtain empirical evidence related to the effect of Bank Size, Capital Adequacy Ratio, Non Performing Loan, Loan to Deposit Ratio, and Board Size on Economic Value Added Bank in banking companies listed on the Indonesia Stock Exchange in the period 2017 to 2020. The research design used in this study was from the independent variable to the dependent variable to test the effect of the independent variable on the dependent variable used in the study. Purposive sampling method was used in this study. A total of 41 banks were used as research samples. In this study, the processing of data that has been collected using multiple linear regression analysis techniques is processed with SPSS version 26.0 software.The findings in this study showed that Bank Size had a significant positive effect on banking profitability (EVA). CAR and Board Size have a significant negative effect on banking profitability (EVA). NPL and LDR have no significant negative effect on banking profitability (EVA).
PENGARUH LEVERAGE, ACCOUNTING CONSERVATISM TERHADAP EARNINGS QUALITY DENGAN FIRM SIZE SEBAGAI MODERASI
Authors: Metta S Irene , Viriany Viriany 
Published: May 2024

The aim of this research to show empirical evidence the effect of leverage, accounting conservatism on earnings quality and to obtain that firm size moderates the effect of leverage on earnings quality in manufacturing companies listed on the Indonesia Stock Exchange. This research used 70 manufacturing companies selected by using purposive sampling and total of data are 280 for four years. The application for processed the research data by using Eviews application version 12 and Microsoft Excel 2019. The results of this research showed that all independent variables have a simultaneous effect on earnings quality and the partial test showed that leverage has positive and significant effect on earnings quality, accounting conservatism has positive and significant effect on earnings quality, and firm size is able to moderate the effect of leverage on earnings quality.
FAKTOR – FAKTOR YANG MEMPENGARUHI TAX AVOIDANCE PADA PERUSAHAAN MANUFAKTUR DI BEI
Authors: Devana Thasya , Sudirgo Tony 
Published: May 2024

This research aims to find out how the value of profitability, leverage and sales growth on tax avoidance in manufacturing companies listed on Indonesia Stock Exchange during 2018-2020. This research uses a purposive sampling method based on data that matches the criteria are 49 companies. The data processing technique uses multiple regression analysis assisted by the SPSS (Statistical Product and Service Solution) for windows released 16 and Microsoft Excel 2007. The results of this research indicate that there is a significant influence between profitability, leverage and sales growth on tax avoidance. The implication of this research is that there is a tendency for companies to take tax avoidance actions which are caused by high levels of profitability, leverage and sales growth. This is done to maximize the company’s net profit.