bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repair of Critical-Sized Rat Calvarial Defects Using Genetically Engineered Bone Marrow-Derived Mesenchymal Stem Cells Overexpressing Hypoxia-Inducible Factor-1α
Authors: Zou Duohong , Zhang Zhiyuan , Ye Dongxia , Tang Aifa , Deng Lianfu , Han Wei , Zhao Jun , Wang Shuhong , Zhang Wenjie , Zhu Chao , Zhou Jian , He Jiacai , Wang Yuanyin , Xu Feng , Huang Yuanliang , Jiang Xinquan 
Published: July 2011

Abstract
The processes of angiogenesis and bone formation are coupled both temporally and spatially during bone repair. Bone marrow-derived mesenchymal stem cells (BMSCs) have been effectively used to heal critical-size bone defects. Enhancing their ability to undergo angiogenic and osteogenic differentiation will enhance their potential use in bone regeneration. Hypoxia-inducible factor-1α (HIF-1α) has recently been identified as a major regulator of angiogenic-osteogenic coupling. In this study, we tested the hypothesis that HIF-1α gene therapy could be used to promote the repair of critical-sized bone defects. Using lentivirus-mediated delivery of wild-type (HIF) or constitutively active HIF-1α (cHIF), we found that in cultured BMSCs in vitro, HIF and cHIF significantly enhanced osteogenic and angiogenic mRNA and protein expression when compared with the LacZ group. We found that HIF-1α-overexpressing BMSCs dramatically improved the repair of critical-sized calvarial defects, including increased bone volume, bone mineral density, blood vessel number, and blood vessel area in vivo. These data confirm the essential role of HIF-1α modified BMSCs in angiogenesis and osteogenesis in vitro and in vivo.
Crystal Structure, Solution and Solid‐state Photoluminescence of a 2D Zinc(II) Supramolecular Architecture
Authors: Ren Yi‐Xia , Jiao Bao‐Juan , Zhang Mei‐Li , Gao Xiao‐Ming , Wang Jiao 
Published: July 2011

AbstractA new 2D zinc(II) supramolecular complex [Zn(2,4‐D)(o‐phen)(H2O)2](NO3) (1) (2,4‐D = 2,4‐dichlorophenoxyacetic acid, o‐phen = 1,10‐phenanthroline), was synthesized and characterized by single‐crystal X‐ray diffraction, elemental analyses, TG analysis, IR, and luminescence spectroscopy. For complex 1, each ZnII ion lies in a pentacoordinate distorted quadrilateral pyramidal configuration. The 8‐member‐ring hydrogen bonds clusters result in 1D ladder‐like supramolecular chains, which further stack up by face‐to‐face π–π stacking interactions into 2D supramolecular layers. The TG analysis shows that complex 1 has high thermal stability. The solution and solid‐state photoluminescence of 1 are reported.
Visitor reaction to pacing behavior: influence on the perception of animal care and interest in supporting zoological institutions
Authors: Miller Lance J. 
Published: July 2011

AbstractMany publications within the field of zoo animal welfare have stated the importance of decreasing stereotypic behavior (e.g., pacing) to help ensure a positive visitor experience. The idea behind these statements is that visitors want to see animals engaged in natural behavior. Additionally, it is thought that watching an animal exhibit species‐appropriate behavior could help increase a visitor's connection to wildlife and ultimately their interest in conservation. However, until recently, no information was available to validate such statements. The purpose of this research was to examine people's reaction to viewing an animal engaged in pacing behavior. Participants were randomly selected to fill out a survey after watching a short video of either a tiger pacing or resting (control). Results indicate that having viewed a tiger pacing significantly decreases people's perception of the level of care animals receive at that facility. In addition, people's interest in supporting zoos decreased as a result of viewing this behavior. Results are discussed from an animal welfare, business, and conservation perspective. Zoo Biol 31: 242–248, 2012. © 2011 Wiley Periodicals, Inc.
Correlation of Vascular Endothelial Growth Factor Expression With Tumor Recurrence and Poor Prognosis in Patients With pN0 Gastric Cancer
Authors: Liu Yan‐feng , Guo Sen , Zhao Rui , Chen Yue‐guang , Wang Xian‐qiang , Xu Ke‐sen 
Published: July 2011

AbstractBackgroundVascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)‐9 play important roles in tumor angiogenesis, development, and progression. This study investigates the expression of VEGF combined with MMP‐9, their correlation with clinical characteristics, and their effect on the prognosis for patients with pN0 gastric cancer after curative surgery.MethodsA total of 55 patients were enrolled in the study. They were analyzed by immunohistochemistry, and their correlation with clinical characteristics was then investigated. Their relations and the survival time of patients were retrospectively analyzed.ResultsVEGF and MMP‐9 were positively expressed in 24 (43.6%) and 16 (29.1%) patients, respectively, and had a positive correlation (r = 0.324, p = 0.016) in the Spearman rank correlation analysis. Univariate analysis showed that VEGF, MMP‐9 expression, vascular invasion, T stage, and tumor size were associated with tumor recurrence as well as the disease‐specific (DSS) and overall (OS) survival rates. Patients with positive VEGF expression showed significantly higher recurrence and poorer DSS and OS rates compared with those with negative VEGF expression. Multivariate analysis showed that VEGF expression, vascular invasion, T stage (serosal invasion), and tumor size were significant independent prognostic factors for tumor recurrence, DSS, and OS in patients with pN0 gastric cancer with the exception that T stage was not for DSS.ConclusionsVEGF expression, vascular invasion, T stage (serosal invasion), and tumor size can be used as valuable prognosticators in predicting tumor recurrence and prognosis for patients with pN0 gastric cancer after curative surgery. VEGF may have a synergistic effect with MMP‐9 during tumor angiogenesis, development, and progression.
External Validation of Two Nomograms for Predicting Patient Survival After Hepatic Resection for Metastatic Colorectal Cancer
Authors: Takakura Yuji , Okajima Masazumi , Kanemitsu Yukihide , Kuroda Shintaro , Egi Hiroyuki , Hinoi Takao , Tashiro Hirotaka , Ohdan Hideki 
Published: July 2011

AbstractBackgroundTwo nomograms are available for predicting patient survival after hepatic resection for metastatic colorectal cancer (CRC). However, they have not been externally validated using other databases, and so their universal applicability has not been established. We aimed to examine the validity of these nomograms for predicting patient survival after hepatic resection for metastatic CRC in different institutions.MethodsWe analyzed the cases of 113 patients who underwent hepatic resection for metastatic CRC at Hiroshima University Hospital between 1995 and 2006. In this patient set, we assessed the predictive value of the Kattan nomogram of the Memorial Sloan‐Kettering Cancer Center (MSKCC) (United States) and the Kanemitsu nomogram from the Aichi Cancer Center (Japan). The concordance index was used as an accuracy measure for comparing these two nomograms. The predictive accuracy of these nomograms was compared with that of conventional predictive models.ResultsThe 3‐, 5‐, and 10‐year overall survival rates in our cohort were 66.3%, 52.4%, and 42.7%, respectively. The concordance indexes of the pre‐ and postoperative Kanemitsu nomogram and that of the Kattan nomogram were 0.70, 0.69, and 0.68, respectively. These values were higher than those obtained using other models for hepatic metastatic CRC, including the clinical risk score of the MSKCC and the grading system of the Japanese Society for Cancer of the Colon and Rectum.ConclusionsThe high predictive accuracy of both nomograms shows that these predictive tools can be used in different institutions. Patient counseling and adjuvant therapy decision‐making should benefit from use of these nomograms.
Reinventing Mpowerment for Black Men: Long‐Term Community Implementation of an Evidence‐Based Program
Authors: Miller Robin Lin , Forney Jason C. , Hubbard Peter , Camacho Lizeth M. 
Published: July 2011

AbstractAlthough research on the dissemination of evidence‐based programs to community providers has rapidly grown, research describing implementation of evidence‐based efforts remains a central need. Insight on implementation may aid in developing approaches to assisting organizations to use a variety of evidence‐based practices effectively and to improve the design of programs that can and will be used faithfully. This mixed‐method case study provides a descriptive account of the implementation of an evidence‐based program designed principally for white gay and bisexual young men, the Mpowerment Project, in the 4th and 5th years after its initial adoption by an organization serving black gay and bisexual men. We identify factors that have shaped how the program has evolved and is currently operated. The case study results highlight how the dynamic interaction of practice‐based experiences, skills, relationships, local context, and practitioner judgments about the relevance and credibility of evidence for specific actions propel the reinvention of evidence‐based program procedures. Implications for research and practice are provided.
Using a Family History Intervention to Improve Cancer Risk Perception in a Black Community
Authors: Murthy Vinaya S. , Garza Mary A. , Almario Donna A. , Vogel Kristen J. , Grubs Robin E. , Gettig Elizabeth A. , Wilson John W. , Thomas Stephen B. 
Published: July 2011

AbstractFew studies examine the use of family history to influence risk perceptions in the African American population. This study examined the influence of a family health history (FHH) intervention on risk perceptions for breast (BRCA), colon (CRC), and prostate cancers (PRCA) among African Americans in Pittsburgh, PA. Participants (n = 665) completed pre‐ and post‐surveys and FHHs. We compared their objective and perceived risks, classified as average, moderate, or high, and examined the accuracy of risk perceptions before and after the FHH intervention. The majority of participants had accurate risk perceptions post‐FHH. Of those participants who were inaccurate pre‐FHH, 43.3%, 43.8%, and 34.5% for BRCA, CRC, and PRCA, respectively, adopted accurate risk perceptions post‐FHH intervention. The intervention was successful in a community setting. It has the potential to lead to healthy behavior modifications because participants adopted accurate risk perceptions. We identified a substantial number of at‐risk individuals who could benefit from targeted prevention strategies, thus decreasing racial/ethnic cancer disparities.
The impact of cis-acting polymorphisms on the human phenotype
Authors: Jones Bryony L. , Swallow Dallas M. 
Published: July 2011

Abstract

Cis-acting polymorphisms that affect gene expression are now known to be frequent, although the extent and mechanisms by which such variation affects the human phenotype are, as yet, only poorly understood. Key signatures of cis-acting variation are differences in gene expression that are tightly associated with regulatory SNPs or expression Quantitative Trait Loci (eQTL) and an imbalance of allelic expression (AEI) in heterozygous samples. Such cis-acting sequence differences appear often to have been under selection within and between populations and are also thought to be important in speciation. Here we describe the example of lactase persistence. In medical research, variants that affect regulation in cis have been implicated in both monogenic and polygenic disorders, and in the metabolism of drugs. In this review we suggest that by further understanding common regulatory variations and how they interact with other genetic and environmental variables it will be possible to gain insight into important mechanisms behind complex disease, with the potential to lead to new methods of diagnosis and treatments.
Radiofrequency ablation of lung tumours
Authors: Bargellini Irene , Bozzi Elena , Cioni Roberto , Parentini Barbara , Bartolozzi Carlo 
Published: July 2011

AbstractPulmonary radiofrequency ablation (RFA) has become an increasingly adopted treatment option for primary and metastatic lung tumours. It is mainly performed in patients with unresectable or medically inoperable lung neoplasms. The immediate technical success rate is over 95%, with a low periprocedural mortality rate and 8–12% major complication rate. Pneumothorax represents the most frequent complication, but requires a chest tube drain in less than 10% of cases. Sustained complete tumour response has been reported in 85–90% of target lesions. Lesion size represents the most important risk factor for local recurrence. Survival data are still scarce, but initial results are very promising. In patients with stage I non-small-cell lung cancer, 1- and 2-year survival rates are within the ranges of 78–95% and 57–84%, respectively, with corresponding cancer-specific survival rates of 92% and 73%. In selected cases, the combination of RFA and radiotherapy could improve these results. In patients with colorectal lung metastasis, initial studies have reported survival data that compare favourably with the results of metastasectomy, with up to a 45% 5-year survival rate. Further studies are needed to understand the potential role of RFA as a palliative treatment in more advanced disease and the possible combination of RFA with other treatment options.
IV.—The Northfleet 50-foot Submergence later than the Coombe Rock of post-Early Mousterian times
Authors: Burchell J. P. T. 
Published: July 2011

Researches conducted during the past twenty years have definitely succeeded in establishing the sequence, both archaeological and geological, of the Boyn Hill or ‘100-foot’ terrace of the Lower Thames. The culture-stages there represented are set out hereunder in ascending order, beginning with the oldest:(1) Clactonian 1; these specimens, many of which are striated, have been derived from some earlier deposit not yet located :(2) Clactonian 2 and 3 :(3) Acheulian :(4) Early Mousterian (Levalloisian A of mid-Pleistocene times).
II.—The Jutish Style A. A Study of Germanic Animal Art in Southern England in the Fifth Century A.D
Authors: Hawkes Sonia Chadwick 
Published: July 2011

In 1915 Professor Baldwin Brown drew attention to a class of metalwork, found in Anglo-Saxon graves in the south of England, and decorated with examples of a distinctive animal style, more naturalistic than Anglo-Saxon style I. This style he considered to be a direct descendant of late Roman art forms, although produced, not in the years immediately following the Anglo-Saxon settlement, but after a considerable time lapse, towards the middle of the sixth century. A similar view was expressed in 1923 by Reginald Smith. Nils Åberg, writing in 1926, was noncommittal about dates, but saw the inspiration for the style in a blend of late Roman and Eastern Mediterranean tradition. It was not until 1936, however, that a more detailed critical estimate of the objects was published, this time by E. T. Leeds in his Early Anglo-Saxon Art and Archaeology. Leeds compared their decoration with that of examples of Gallo-Roman art in the late fourth and early fifth centuries and concluded that they came from the same style milieu. He wrote:All the pieces here noticed clearly belong to a cultural phase, presenting indeed many affinities to the Germanic style of the settlement period; but, in reality, they represent a continental style antecedent to that development in southern England. … There is every reason to believe that they are objects ante-dating the invasion, and, if it is desired to know what native women were wearing before or at the time of Hengist’s landing, this group supplies the information.
Hyperglycaemia is negatively associated with systemic and cerebral oxygen transport in neonates after the Norwood procedure
Authors: Zhang Gencheng , Cai Sally , Li Jia 
Published: July 2011

AbstractObjectiveHyperglycaemia has been identified as a risk factor for adverse outcomes in critically ill patients, including those who have undergone cardiopulmonary bypass. Tight glucose control with insulin therapy has been shown to improve outcomes, but is not common practice for children following cardiopulmonary bypass. We examined the relationship between blood glucose level and systemic and cerebral oxygen transport in a uniform group of neonates after the Norwood procedure.MethodsSystemic oxygen consumption was measured using respiratory mass spectrometry in 17 neonates for 72 hours postoperatively. Cardiac output, systemic and total pulmonary vascular resistances – including the Blalock–Taussig shunt, systemic oxygen delivery and oxygen extraction ratio, as well as arterial lactate and glucose, were measured at 2- to 4-hour intervals. Cerebral oxygen saturation was measured by near-infrared spectroscopy.ResultsBlood glucose levels ranged from 2.8 to 24.6 millimoles per litre. Elevated glucose level showed a significant negative correlation with cardiac output (p = 0.02) and cerebral oxygen saturation (p = 0.03), and a positive correlation with oxygen extraction ratio (p = 0.03). It tended to correlate positively with systemic vascular resistance (p = 0.09) and negatively with oxygen delivery (p = 0.09), but did not correlate with oxygen consumption (p = 0.13).ConclusionsHyperglycaemia is negatively associated with systemic haemodynamics, oxygen transport, and cerebral oxygenation status in neonates after the Norwood procedure. Further study is warranted to examine tight glucose control with insulin therapy on postoperative systemic and cerebral oxygen transport and functional outcomes in neonates after cardiopulmonary bypass.
Cardiovascular considerations of attention deficit hyperactivity disorder medications: a report of the European Network on Hyperactivity Disorders work group, European Attention Deficit Hyperactivity Disorder Guidelines Group on attention deficit hyperactivity disorder drug safety meeting
Authors: Hamilton Robert M. , Rosenthal Eric , Hulpke-Wette Martin , Graham John G. I. , Sergeant Joseph 
Published: July 2011

AbstractRegulatory decisions regarding attention deficit hyperactivity disorder drug licensing and labelling, along with recent statements from professional associations, raise questions of practice regarding the evaluation and treatment of patients with attention deficit hyperactivity disorder. To address these issues for the European community, the European Network for Hyperkinetic Disorders, through its European Attention Deficit Hyperactivity Disorder Guidelines Group, organised a meeting between attention deficit hyperactivity disorder specialists, paediatric cardiovascular specialists, and representatives of the major market authorisation holders for attention deficit hyperactivity disorder medications. This manuscript represents their consensus on cardiovascular aspects of attention deficit hyperactivity disorder medications. Although sudden death has been identified in multiple young individuals on attention deficit hyperactivity disorder medication causing regulatory concern, when analysed for exposure using currently available data, sudden death does not appear to exceed that of the general population. There is no current evidence to suggest an incremental benefit to electrocardiography assessment of the general attention deficit hyperactivity disorder patient. Congenital heart disease patients have an increased prevalence of attention deficit hyperactivity disorder, and can benefit from attention deficit hyperactivity disorder therapies, including medication. The attention deficit hyperactivity disorder specialist is the appropriate individual to evaluate benefit and risk and recommend therapy in all patients, although discussion with a heart specialist is reasonable for congenital heart disease patients. For attention deficit hyperactivity disorder patients with suspected heart disease or risk factor/s for sudden death, assessment by a heart specialist is recommended, as would also be the case for a non-attention deficit hyperactivity disorder patient. The identification of risk factors for sudden death should not automatically exclude the use of attention deficit hyperactivity disorder medication.
The sinister course of an intramural right coronary artery
Authors: Yim Deane L. S. , Hamilton Mark C. K. , Tulloh Robert M. R. 
Published: July 2011

AbstractWe report the case of an adolescent who was presented with long-standing exertional symptoms, and was diagnosed with an anomalous right coronary arterial origin arising above the commissural junction between the left and right aortic sinus, with inter-arterial and intramural compression. The precise origin of this lesion outside the aortic sinuses is unusual, and multi-detector computed tomography gave excellent definition and spatial resolution of the anomalous origin and course. It is crucial to have a high index of suspicion of exertional symptoms, as sudden death may be the first manifestation of an anomalous coronary artery.
INVARIANT EINSTEIN METRICS ON GENERALIZED FLAG MANIFOLDS WITH TWO ISOTROPY SUMMANDS
Authors: ARVANITOYEORGOS ANDREAS , CHRYSIKOS IOANNIS 
Published: July 2011

AbstractLet M=G/K be a generalized flag manifold, that is, an adjoint orbit of a compact, connected and semisimple Lie group G. We use a variational approach to find non-Kähler homogeneous Einstein metrics for flag manifolds with two isotropy summands. We also determine the nature of these Einstein metrics as critical points of the scalar curvature functional under fixed volume.