bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of a diagnostic model of endometriosis based on disulfidptosis‐related genes
Authors: Shi Hongyan , Zhou Caixia , Zhao Yaoyao 
Published: April 2024

AbstractObjectivesWe aimed to establish a diagnostic model of endometriosis (EM) based on disulfidptosis‐related genes (DRGs).Materials and MethodsThe mRNA expression data of EM were downloaded from the gene expression omnibus database and subjected to differential analysis, and co‐expression analysis was performed based on 10 disulfidptosis genes to acquire DRGs. The differentially expressed DRGs were subjected to biofunctional analysis. Lasso analysis and support vector machine‐recursive feature elimination (SVM‐RFE) analysis were employed to extract the intersection of feature genes as biomarkers, and the diagnostic values of biomarkers for EM were evaluated based on receiver operating characteristic curves. The correlations between biomarkers and the immune microenvironment were assessed by Pearson analysis of biomarkers and immune cell infiltration levels.ResultsTransforming growth factor β stimulated protein clone 22 domain family member 4 (TSC22D4), and F‐box/SPRY domain‐containing protein 1 (FBXO45) worked as the diagnostic classifiers in EM, with an obvious decrease in FBXO45 expression and an evident increase in TSC22D4 expression. The areas under the curves of FBXO45 and TSC22D4 were 0.752 and 0.706, respectively, and the area of FBXO45 combined with TSC22D4 reached 0.865, suggesting that TSC22D4 and FBXO45 had high predictive values. The diagnostic markers were closely correlated with immune cell infiltration.ConclusionThe diagnostic markers constructed based on disulfidptosis are good predictors for EM, which have close correlations with EM.
Hand to Face: A Phenomenological View of Body Image Development in Infants
Authors: Tanaka Shogo 
Published: April 2024

AbstractThis paper attempts to theoretically reconsider body image development in infants from a phenomenological viewpoint of the body. Because body image is defined as the mental picture of one's whole body, our main question is how we obtain the perspective to view our own body as a whole in constituting body image. First, focusing on the development of mirror self‐cognition in the first 2 years of life, we find that this perspective derives from that of others in embodied interactions with infants. We then trace the process whereby others' perspectives appear in dyadic interactions between infants and caregivers. Since joint attention is established around 9 months, this dyadic interaction is transformed into a triadic relationship between the infant, caregiver, and object, which is experienced as “secondary intersubjectivity.” Infant body image is constituted gradually within this intersubjective context. Based on phenomenological descriptions, we propose that the hands are the first organ and the face the last organ to be incorporated into one's body image. We conclude that the constitution of body image is not merely a sensory task of integrating proprioceptive and visual images of the body, but a social task of internalizing others' perspectives regarding one's own body.
A new giant Jurassic lacewing larva reveals a particular aquatic habit and its significance to the palaeoecology
Authors: Kong Bowen , Shih Chungkun , Ren Dong , Wang Yongjie 
Published: April 2024

AbstractNeuroptera, as a small relic group of Insecta undergoing a rapid species diversification during the Mesozoic Era, is known by diverse extinct endemic lineages preserved as impression fossils and in amber. The current understanding of Mesozoic neuropterans′ diversity has mainly focused on the adults, because the contemporaneous larvae have been fairly rare especially for the Jurassic lacewings. Herein, a new giant lacewing larva, Natator giganteus gen. et sp. nov., is described from the Middle Jurassic Daohugou Beds of China. The remarkable larva is characterized by its impressively large body size, distinctively elongated cervix, and presence of swimming hairs on legs, which provide direct evidence to reveal an aquatic habit for the Jurassic lacewing larva. The morphological analysis indicates this giant larva would have probably inhabited the benthic environments of Jurassic montane rivers and streams. In addition, its morphological specialization suggests that it might have adopted an ambush predation strategy to catch its prey. The finding enhances our knowledge of the species diversity and morphological plasticity for the Jurassic lacewing larvae, and reveals that the aquatic lineages of Neuroptera exhibited dramatically structural and ecological convergence across the evolutionary process.
Cytosolic ABA Receptor Kinases phosphorylate the D6 PROTEIN KINASE leading to its stabilization which promotes Arabidopsis growth
Authors: He Juan , Li Xiaoyi , Yu Qin , Peng Lu , Chen Li , Liu Jiajia , Wang Jianmei , Li Xufeng , Yang Yi 
Published: April 2024

AbstractThe polar auxin transport is required for proper plant growth and development. D6 PROTEIN KINASE (D6PK) is required for the phosphorylation of PIN‐FORMED (PIN) auxin efflux carriers to regulate auxin transport, while the regulation of D6PK stabilization is still poorly understood. Here, we found that Cytosolic ABA Receptor Kinases (CARKs) redundantly interact with D6PK, and the interactions are dependent on CARKs' kinase activities. Similarly, CARK3 also could interact with paralogs of D6PK, including D6PKL1, D6PKL2, and D6PKL3. The genetic analysis shows that D6PK acts the downstream of CARKs to regulate Arabidopsis growth, including hypocotyl, leaf area, vein formation, and the length of silique. Loss‐of‐function of CARK3 in overexpressing GFP‐D6PK plants leads to reduce the level of D6PK protein, thereby rescues plant growth. In addition, the cell‐free degradation assays indicate that D6PK is degraded through 26 S proteasome pathway, while the phosphorylation by CARK3 represses this process in cells. In summary, D6PK stabilization by the CARK family is required for auxin‐mediated plant growth and development.
Mechanistic studies on protective effects of total flavonoids from Ilex latifolia Thunb. on UVB‐radiated human keratinocyte cell line (HaCaT cells) based on network pharmacology and molecular docking technique
Authors: Ma Yunge , Li Yingyan , Yao Yike , Huang Tao , Lan Chong , Li Liyan 
Published: April 2024

AbstractThe aim of the present research is to investigate anti‐UVB radiation activity of total flavonoids from Ilex latifolia Thunb. (namely large‐leaved Kuding tea) on human keratinocyte cell line (HaCaT cells) based on network pharmacology and molecular docking technique. Network pharmacology was used to screen target genes of active ingredients from Ilex latifolia Thunb. associated with UVB irradiation. The possible signaling pathways were analyzed by KEGG enrichment and verified by cellular experiments. Molecular docking was used to assess the affinity between the active ingredients and the core targets. The prediction of network pharmacology and molecular docking was identified by series experiment in UVB‐irradiated HaCaT cells. Network pharmacology results showed that the active ingredients of Ilex latifolia Thunb. for anti‐UVB irradiation were mainly flavonoids, and the possible signaling pathways were involved in PI3K‐AKT, apoptosis, MAPKs, NF‐κB, and JAK‐STAT3. Molecular docking indicated key binding activity between AKT1‐Glycitein, STAT3‐Formononetin, CASP3‐Formononetin, TNF‐Kaempferol, CASP3‐Luteolin, and AKT1‐Quercetin. The total flavonoid pretreatment (0.25–1.0 mg/mL) down‐regulated the expression of IL‐6, IL‐1β, and TNF‐α in the cells determined by ELISA. The expression of phosphor PI3K, phosphor AKT, phosphor JAK, phosphor STAT3, phosphor JNK, and phosphor p38 MAPKs and COX‐2 proteins in cytosolic and NF‐κB p65 protein in nucleus were down‐regulated and determined by western blot. It also protected UVB‐irradiated cells from apoptosis by reducing apoptosis rate and down‐regulating active‐caspase 3. In a word, the total flavonoid treatment protected HaCaT cells from UVB injuries effectively, and the potential mechanism involves PI3K‐AKT, JAK‐STAT3, MAPK, and NF‐κB pathway by anti‐inflammatory and apoptosis action in cells. The mechanism in vivo experiment needs to be further confirmed in future.
Effects of gait retraining using minimalist shoes on the medial gastrocnemius muscle‐tendon unit behavior and dynamics during running
Authors: Deng Liqin , Dai Boyi , Zhang Xini , Xiao Songlin , Fu Weijie 
Published: April 2024

AbstractThe effects of a 12‐week gait retraining program on the adaptation of the medial gastrocnemius (MG) and muscle‐tendon unit (MTU) were investigated. 26 runners with a rearfoot strike pattern (RFS) were randomly assigned to one of two groups: gait retraining (GR) or control group (CON). MG ultrasound images, marker positions, and ground reaction forces (GRF) were collected twice during 9 km/h of treadmill running before and after the intervention. Ankle kinetics and the MG and MTU behavior and dynamics were quantified. Runners in the GR performed gradual 12‐week gait retraining transitioning to a forefoot strike pattern. After 12‐week, (1) ten participants in each group completed the training; eight participants in GR transitioned to non‐RFS with reduced foot strike angles; (2) MG fascicle contraction length and velocity significantly decreased after the intervention for both groups, whereas MG forces increased after intervention for both groups; (3) significant increases in MTU stretching length for GR and peak MTU recoiling velocity for both groups were observed after the intervention, respectively; (4) no significant difference was found for all parameters of the series elastic element. Gait retraining might potentially influence the MG to operate at lower fascicle contraction lengths and velocities and produce greater peak forces. The gait retraining had no effect on SEE behavior and dynamics but did impact MTU, suggesting that the training was insufficient to induce mechanical loading changes on SEE behavior and dynamics.
“I never planned for it”—Exploration of expectations about caring for older parents
Authors: De Poli Chiara , Wittenberg Raphael , Rehill Amritpal , Stevens Madeleine , Brimblecombe Nicola 
Published: April 2024

AbstractThe projected increase in older dependent adults will continue straining formal care services whilst increasing the reliance on unpaid carers, in England and internationally. While motivations and willingness to care among unpaid carers have been explored, expectations around the caregiving role remain under‐researched. This article delves into expectations of middle‐aged individuals around providing care to an older parent in the future. Data collected through six focus groups with 35 mid‐life individuals, a mix of individuals with and without caring experience, were analysed thematically, cross‐sectionally, and with reference to different phases in the caregiving trajectory. Participants showed predicted, in some cases normative, expectations about taking on the role of carer for an older parent. Such expectations were rooted in emotional and socio‐cultural factors and influenced how people self‐identified as a carer. Expectations about what the role would entail were unformed: they were described as conditional on the uncertain and changing care needs of the older parents (‘caregiving creep’). Those with caring experience highlighted that, in hindsight, their prior expectations did not match their actual experience of the role, requiring greater time commitment and impacting their life in ways they had not anticipated. When thinking about the future, participants envisaged stepped changes in care arrangements to meet increasing, albeit uncertain, care needs, but acknowledged their lack of awareness around the care options available to them. Policies aiming to improve general awareness about caregiving, support early identification of carers, and address their information need throughout their caregiving journey should be a priority.
Efficacy of antibiotic prophylaxis to preventing brucellosis in accidental exposure: A systematic review
Authors: Nascimento Silva Sarah , Cota Glaucia , Souza Kathiaja Miranda , de Freitas Marina Gonçalves , Carvalho Janaína de Pina , Galvão Endi Lanza 
Published: April 2024

AbstractBackgroundAntibiotic prophylaxis to prevent brucellosis after accidental exposure to Brucella is an important topic in public health. This study aimed to systematically review the efficacy of antibiotic prophylaxis following accidental exposure to Brucella in preventing human brucellosis disease.MethodsThe study protocol was registered in PROSPERO (CRD42023456812). The outcomes included the incidence of brucellosis disease, adverse events rate, and antibiotic prophylaxis adherence. A comprehensive literature search, conducted until 20 November, 2023, involved Medline, Embase, Cochrane Library, and LILACS databases. Descriptive analysis and meta‐analysis using R software were performed, risk of bias was assessed using JBI Critical appraisal tools, and certainty of evidence was assessed using the GRADE tool.ResultsAmong 3102 initially identified records, eight studies involving 97 individuals accidentally exposed, all focused on high‐risk accidental exposure to Brucella in laboratory settings, were included in the review. All studies reported the prophylactic treatment comprising doxycycline at a dosage of 100 mg twice daily, combined with rifampicin at 600 mg, both administered over 21 days. Prophylaxis adherence was reported in 86% of cases, and incidence of brucellosis post‐treatment was 0.01. Adverse events, mainly gastrointestinal, occurred in 26% of cases. Critical appraisal revealed limitations in reporting demographics and clinical information. The certainty of evidence was rated as ‘very low,’ emphasising the need for caution in interpreting the observed outcomes due to study design constraints and the absence of comparative groups.ConclusionsPEP is an alternative practice reported in the literature, used in accidents with high‐risk exposure to Brucella. The currently available evidence of the efficacy of antibiotic prophylaxis is insufficient to support a recommendation for or against the widespread use of antibiotic prophylaxis, so caution is needed in interpreting results due to the very low certainty of evidence, primarily stemming from case series and lack of comparative groups.
Chlorine Solubility in Silicate Melts: New Experiments and Thermodynamic Mixing Model
Authors: Aranovich L. Y. , Golunova M. A. , Connolly J. A. D. , Ivanov M. V. 
Published: April 2024

Abstract
We present new experimental data on Cl solubility in model basalt melts of eutectic compositions diopside (Di)–albite (Ab) and Di–anorthite ± quartz (Qtz). The starting glasses were equilibrated with aqueous NaCl–CaCl2 fluid at 4 kbar in the temperature range of 900–1200°C. The experiments show that Cl solubility decreases with increasing NaCl in the fluid. Ca–Na partitioning between melts and fluid is weekly temperature dependent and resembles that of the plagioclase–fluid system. The newly obtained experimental data, along with previously published results on the model granite melting in the presence of (Na,K)Cl brines (Aranovich et al., 2013), are used to calibrate an empirical thermodynamic model for salt species (NaCl, KCl, and CaCl2) in silicate melt. Calculations show that Cl solubility in haplogranite melt decreases with increasing K/Na ratio in the fluid (and correspondingly, melt). The data acquired on Ca and Na partitioning between melt and fluid make it possible to model the evolution of the Ca/Na ratio in the crystallization course of basalt melts. At a high pressure (10 kbar), Cl solubility in model granite increases with increasing Н2О content. The calculated phase diagram for a simple pseudo-ternary system Ab–H2O–NaCl demonstrates complex phase relations and, correspondingly, evolution of the Н2О and NaCl concentrations in the melt. This complex evolution is illustrated by data on the composition of quartz-hosted melt and fluid inclusions from granites in the Verkhneurmisskii massif in the Badzhal volcano-plutonic zone.
Paleoproterozoic Dacite Dikes of the Vorontsovka Terrane, Volga–Don Orogen: Geochemistry, Age, and Petrogenesis
Authors: Savko K. A. , Samsonov A. V. , Korish E. Kh. , Bazikov N. S. , Larionov A. N. 
Published: April 2024

Abstract
Metamorphosed dacitic porphyry dikes were first found in the western part of the Vorontsovka terrane, which is located in the Paleoproterozoic Volga–Don orogen at the margin of Archean Sarmatia and Volga–Ural cratons. The magmatic protolith age for the metadacites is ca. 2.07 Ga. These are ferrous, metaluminous calc-alkali I-type granitoids. The sodium specialization of the rocks and their low concentrations of Mg, Cr, Ni, and incompatible elements, with significant REE fractionation, the absence of Eu* anomalies, high Sr/Y ratio, remarkably high (Gd/Yb)n values (>10), and the radiogenic Nd isotopic composition indicate that the dacitic melts were derived from a juvenile mafic source. According to petrogenetic estimations, such conditions could be caused by the partial melting of depleted N-MORB basites in equilibrium with an eclogitic residue. The dacitic magmas were likely generated by the partial melting of mafic rocks at lower levels of the significantly thickened crust (>60 km) in relation to collision processes.
Malignant tumour in pregnancy: Ewing-like sarcoma of the gluteal region
Authors: Gouveia Inês , Xavier Marta , Silva Joana , Martins Pedro 
Published: April 2024

We report a case of an Ewing-like sarcoma of the gluteal region with ongoing growth during the second trimester of pregnancy and noted during the third trimester. This lesion was consequently studied to infer its malignant potential. Several examinations were conducted to characterise this lesion, such as ultrasound and MR, which showed signs of tumourous invasion of the deep tissues of the gluteal region.Given that the pregnancy was at the end of the third trimester, the decision was made to schedule the delivery at 37 weeks of gestation and treat the tumour afterwards to balance maternal and fetal health.This case illustrates the need for a detailed investigation and guidance by a multidisciplinary team to provide prenatal counselling regarding a malignant tumour during pregnancy.
National capacity strengthening within the context of an international vector control partnership: findings from a qualitative study conducted within the Ugandan ‘Tiny Targets’ programme
Authors: Aggrey Siya , Pulford Justin , Bahungirehe John Bosco , Wamboga Charles , Hope Andrew 
Published: April 2024

IntroductionThe Ugandan Tiny Target programme is an example of an international vector control partnership that held specific capacity strengthening objectives in support of a disease elimination goal. Drawing on this experience, we sought to derive transferable lessons that may inform capacity strengthening approaches within other partnership-based vector control programmes.MethodsA longitudinal qualitative study encompassing semistructured interviews conducted with Ugandan partners working on the Tiny Target programme. Data analysis was informed by a general inductive approach.ResultsCapacity strengthening priorities evolved over time initially focusing on the immediate capacities needed to perform roles and responsibilities assigned within the partnership and then shifting towards more advanced, transferable knowledge and skills. A distinction between operational and systemic priorities was observed: the former was necessary to support successful programme implementation whereas the latter reflected fundamental limitations or complexities within the Ugandan context that were bypassed by including an international partner. Systemic priorities were fewer in number than their operational counterparts, although substantially harder to resolve. The largest apparent threat to the long-term sustainability of reported capacity gains was their concentration within a small number of individuals.ConclusionOur study highlights three key lessons that may inform the design of national capacity strengthening activities conducted within the context of international vector control partnerships, including (1) Multiple approaches to strengthen capacity are needed and that can adapt to changing capacity strengthening priorities over time; (2) Balancing operational and systemic capacity strengthening priorities, the latter becoming increasingly important within longer-term partnerships and (3) Partnership members in focal country/ies should be supported to actively facilitate the transfer of newly acquired knowledge and skills to relevant colleagues/communities outside of the partnership. The generic nature of these recommendations suggests they are likely to be of benefit to many and diverse international partnerships within the wider global health space.
Trends in motives for trying to stop smoking: a population study in England, 2018–2023
Authors: Jackson Sarah E , Cox Sharon , Buss Vera , Brown Jamie 
Published: April 2024

IntroductionSince 2020, people in England have lived through a global pandemic and national cost-of-living and healthcare crises, each of which might have affected motivations to stop smoking.ObjectiveTo examine changes in the factors motivating people to stop smoking over this period.MethodsData were drawn from a nationally representative monthly cross-sectional survey in England, 2018–2023. Participants were 5777 past-year smokers who made one or more serious attempt to quit in the past year. Participants reported factors contributing to their most recent attempt to quit. We estimated time trends in the proportion of attempts to quit that were motivated by (i) health concerns, (ii) cost, (iii) social factors and (iv) health professional advice, and calculated prevalence ratios (PRs) for the change in prevalence across the whole time series (May 2023 vs March 2018).ResultsUp to 2020, one in two attempts to quit were motivated by health concerns (mean monthly proportion 51.0%), one in five by social factors (20.2%) and cost (19.9%) and one in six by health professional advice (16.5%). In 2020, the proportion of attempts to quit motivated by health concerns, social factors and cost increased—to high levels of 56.2%, 23.9% and 25.8%, respectively—and those motivated by health professional advice fell to 8.0%. Rises in health-related and social motives soon returned to baseline levels (52.0% in May 2023 vs 52.5% in March 2018; PR=0.99, 95% CI 0.86 to 1.14) or below baseline (16.0% vs 21.6%; PR=0.74, 95% CI 0.54 to 1.01), respectively. However, attempts to quit motivated by cost increased further during 2022–2023 (reaching 25.4% in May 2023 vs 19.1% in March 2019; PR=1.33, 95% CI 1.01 to 1.76) and those motivated by health professional advice remained suppressed (8.5% vs 14.2%; PR=0.60, 95% CI 0.40 to 0.89).ConclusionsHealth concerns are the most common motive for trying to stop smoking. The relative importance of other motives has shifted since 2020, with cost motivating a greater proportion of attempts to quit, and social factors and health professional advice motivating a smaller proportion.
A medicina na Guerra do Paraguai (IV): Mato-Grosso
Authors: Souza Luiz de Castro 
Published: April 2024

IX ASSALTO E RETOMADA DE CORUMBÁ. O presidente Dr. J. V. Couto de Magalhães, que havia assumido o govêrno da província de Mato Grosso, em 2 de fevereiro de 1867, organiza um batalhão provisório de infantaria, apronta o 19, 59 e 6. da Guarda Nacional e forma uma esquadrilha de pequenos vapores.