bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dynamics of communicative practices in transmigrational contexts: ‘insulting remarks’ and ‘stylized category animations’ in everyday interactions among male youth in Germany
Authors: Günthner Susanne 
Published: June 2011

AbstractThis paper examines “insulting remarks” and “stylized category animations” as communicative practices in interactions among young men with a migrant background living in Germany. On the basis of a detailed investigation of informal interactions among young men in various German youth centers, I will show how the participants make use of these communicative practices as interactional resources to contextualize “belonging”/“association” versus “otherness” in transmigrational contexts. As part of their communicative household, these practices are closely connected to the construction of a cultural identity among these young men. I will argue that focusing on the development and dynamics of communicative practices can provide new insight into the workings of social and cultural identities as well as into linguistic diversity in modern societies.
Image Analysis Technique for Monitoring Early Age Shrinkage Strains with Depth from the Top Surface of Monolithic Cementitious Prism Specimens
Authors: Ong K. C. G. , Chandra L. R. 
Published: June 2011

Abstract
This paper describes the use of the image analysis technique for monitoring the variation of early age shrinkage strains with respect to the depth from the top surface of ordinary Portland cement mortar and concrete prism specimens starting as early as 30 min after adding water to the mixture. The applicability of the image analysis technique was demonstrated on both sealed and unsealed cementitious prism specimens. As expected, in situations where the top trowelled surface is protected from moisture loss, the shrinkage strains are similar with depth from the top trowelled surface. On the other hand, magnitudes of shrinkage strains monitored vary with depth when the top trowelled surface is exposed to a dry environment from an early age. The results also showed that the effect of settlements on early age shrinkage strains monitored can be minimized by adopting the current image analysis testing arrangement. Furthermore, when the early age shrinkage strains monitored using the image analysis technique were benchmarked against the results obtained via laser sensors, comparable shrinkage strains values were observed on the sealed prism specimen. On the other hand, the laser sensors were found to provide an “average” value of shrinkage strains that develop across the whole cross section of the unsealed prism specimen.
A Meta-analysis of Interventions That Target Children's Screen Time for Reduction
Authors: Maniccia Dayna M. , Davison Kirsten K. , Marshall Simon J. , Manganello Jennifer A. , Dennison Barbara A. 
Published: June 2011

BACKGROUND:Screen time, especially television viewing, is associated with risk of overweight and obesity in children. Although several interventions have been developed to reduce children's screen time, no systematic review of these interventions exists to date.OBJECTIVE:This is a systematic review and meta-analysis of interventions targeting a reduction in children's screen time.METHODS:Effect sizes and associated 95% confidence intervals (CIs) were calculated by using a random-effects model. Heterogeneity tests, moderator analyses, assessment of bias, and sensitivity analyses were conducted. Reliability was assessed with Cohen's κ.RESULTS:The systematic search identified 3002 documents; 33 were eligible for inclusion, and 29 were included in analyses. Most reported preintervention and postintervention data and were published in peer-reviewed journals. Although heterogeneity was present, no moderators were identified. Overall Hedges g (−0.144 [95% CI: −0.217 to −0.072]) and standard mean difference (SMD) (−0.148 [95% CI: −0.224 to −0.071]) indicated that interventions were linked with small but statistically significant reductions in screen time in children. The results were robust; the failsafe N was large, and the funnel plot and trim-and-fill methods identified few missing studies.CONCLUSIONS:Results show that interventions to reduce children's screen time have a small but statistically significant effect. As the evidence base expands, and the number of screen-time interventions increases, future research can expand on these findings by examining the clinical relevance and sustainability of effects, conducting a more thorough analysis of effect modifiers, and identifying critical components of effective interventions.
Mevalonate Kinase Deficiency: A Survey of 50 Patients
Authors: Bader-Meunier Brigitte , Florkin Benoit , Sibilia Jean , Acquaviva Cécile , Hachulla Eric , Grateau Gilles , Richer Olivier , Farber Claire Michèle , Fischbach Michel , Hentgen Véronique , Jego Patrick , Laroche Cécile , Neven Bénédicte , Lequerré Thierry , Mathian Alexis , Pellier Isabelle , Touitou Isabelle , Rabier Daniel , Prieur Anne-Marie , Cuisset Laurence , Quartier Pierre ,   on behalf of the SOFREMIP (Société Francophone pour la Rhumatologie et les Maladies Inflammatoires en Pédiatrie) and CRI (Club Rhumatismes et Inflammations)
Published: June 2011

OBJECTIVE:
The goal of this study was to describe the spectrum of clinical signs of mevalonate kinase deficiency (MKD).

METHODS:
This was a retrospective French and Belgian study of patients identified on the basis of MKD gene mutations.

RESULTS:
Fifty patients from 38 different families were identified, including 1 asymptomatic patient. Symptoms began during the first 6 months of life in 30 patients (60%) and before the age of 5 years in 46 patients (92%). Symptoms consisted of febrile diarrhea and/or rash in 23 of 35 patients (66%). Febrile attacks were mostly associated with lymphadenopathy (71%), diarrhea (69%), joint pain (67%), skin lesions (67%), abdominal pain (63%), and splenomegaly (63%). In addition to febrile attacks, 27 patients presented with inflammatory bowel disease, erosive polyarthritis, Sjögren syndrome, and other chronic neurologic, renal, pulmonary, endocrine, cutaneous, hematologic, or ocular symptoms. Recurrent and/or severe infections were observed in 13 patients, hypogammaglobulinemia in 3 patients, and renal angiomyolipoma in 3 patients. Twenty-nine genomic mutations were identified; the p.Val377Ile mutation was the most frequently found (29 of 38 families). Three patients died of causes related to MKD. The disease remained highly active in 17 of the 31 surviving symptomatic patients followed up for &gt;5 years, whereas disease activity decreased over time in the other 14 patients. Interleukin 1 antagonists were the most effective biological agents tested, leading to complete or partial remission in 9 of 11 patients.

CONCLUSION:
MKD is not only an autoinflammatory syndrome but also a multisystemic inflammatory disorder, a possible immunodeficiency disorder, and a condition that predisposes patients to the development of renal angiomyolipoma.
Institutional Adaptation, Trust and Change in the German Political Economy
Authors: Allen Christopher S. 
Published: June 2011

Henry Farrell, The Political Economy of Trust: Institutions, Interests and Interfirm Cooperation in Italy and Germany (New York: Cambridge University Press, 2009).Jeremy Leaman, The Political Economy of Germany under Chancellors Kohl and Schroeder: Decline of the German Model? (New York: Berghahn, 2009)Wolfgang Streeck, Re-Forming Capitalism: Institutional Change in the German Political Economy (New York: Oxford University Press, 2009)
Le jeu dans la consultation pédopsychiatrique : média de rencontre et socle de parentalité
Authors: de Becker Emmanuel 
Published: June 2011

Résumé Si la place du jeu dans la vie de l’enfant relève de l’évidence sur le plan psychologique, il ne manque pas d’atouts par ailleurs. Levier d’apprentissage et de développement, le jeu assure un rôle non négligeable dans la découverte de soi et de l’autre. Il constitue aussi un média de communication universel, au-delà des barrières de langage, de culture ou de générations. Dans le cadre des consultations pédopsychiatriques, de plus en plus de cliniciens sont attentifs au déploiement des activités ludiques dès le plus jeune âge. Il ne s’agit pas d’offrir « simplement » des jeux, mais de construire une aire de rencontre spécifique entre adulte et enfant, propice au développement de la parentalité. L’article est construit en trois temps successifs : le premier s’attache à rappeler quelques considérations générales sur les définitions et significations du jeu. Les illustrations qui constituent le deuxième temps sont extraites de suivis thérapeutiques impliquant enfant et parent, où le clinicien établit l’alliance par le jeu. Le troisième temps développe les liens entre parentalité et qualités de la mise en jeu entre les protagonistes concernés. In fine, le jeu représente probablement un « outil » de prévention de troubles psychiques ultérieurs.
Psychothérapie des boulimiques et Rorschach
Authors: Gaudriault Pierre , Joly Vincent 
Published: June 2011

Résumé Notre recherche vise à explorer l’évolution psychothérapique de patientes boulimiques dans une perspective psychanalytique au moyen du Rorschach pratiqué avant et après thérapie. L’étude a porté sur 26 cas de boulimie pris en charge sur un mode multifocal, comprenant notamment une thérapie d’orientation psychanalytique. Le retest a été effectué au moins un an après le début du traitement. Des troubles narcissiques et objectaux peuvent être repérés chez les boulimiques à partir d’indices du Rorschach inspirés de la littérature concernant leur évolution avec la thérapie. Les résultats montrent que ces indices progressent d’une façon variable. L’analyse des protocoles au cas par cas, selon le fonctionnement psychique de chaque sujet, nous est apparue plus féconde. Plusieurs types d’évolution psychothérapique ont été repérés : les changements vont dans le sens d’un accroissement de la subjectivation, dans le sens d’une stratégie plus adaptative ou d’une meilleure différenciation par rapport à l’objet.
Les enjeux de l'agressivité dans la relation transféro-contre-transférentielle en milieu médical : l'exemple de l'hémodialyse
Authors: Roques Marjorie , Pommier François 
Published: June 2011

Résumé La maltraitance en milieu de soins, que nous envisageons sous un angle psychanalytique comme agressivité et violence, est généralement abordée du point de vue du soignant face au patient, l’amenant à repenser son rôle et ses conduites. Qu’en est-il lorsque, dans une situation « inverse » ou « inversée », lesdits patients sont susceptibles, par leurs comportements agressifs, de favoriser les contre-attitudes de la part des soignants et du médecin ? Dans ce contexte, le clinicien occupe diverses positions : « porte-parole » des uns et des autres, il examine leurs éprouvés, tente de maintenir un lien entre le médecin et son malade tous deux en proie à des mouvements transféro-contre-transférentiels, et tend, dans un même temps, à se dégager de ses propres éprouvés compassionnels et/ou sadiques envers son patient.
Implantable Collamer Posterior Chamber Intraocular Lenses: A Review of Potential Complications
Authors: Fernandes Paulo , González-Méijome José M. , Madrid-Costa David , Ferrer-Blasco Teresa , Jorge Jorge , Montés-Micó Robert 
Published: June 2011

PURPOSE:
To review the peer-reviewed literature reporting postoperative complications of the most recent models of Visian Implantable Collamer posterior chamber intraocular lenses (ICL, STAAR Surgical Co).

METHODS:
A literature search of the PubMed database was performed to identify all articles related to ICL complications. Articles were obtained and reviewed to identify those that reported complications using the latest ICL designs.

RESULTS:
Cataract was the major postoperative complication reported: 136 (5.2%) in 2592 eyes. Of those, 43.4% (n=59) were reported within 1 year, 15.4% (n=21) between 1 and 3 years, and 35.3% (n=48) ≥3 years after ICL implantation. Twenty-one (15.4%) cataracts were reported as surgically induced, 46 (33.8%) eyes had poor vault (<200 μm), and cataract surgery was carried out in 27.9% (n=38) of eyes. Early acute intraocular pressure increase was also reported to be relatively frequent, whereas acute pupillary block was less frequent and mostly resolved with additional iridotomies. A total of 42 ICLs were explanted due to cataract and IOP. Reported endothelial cell loss varied from 9.9% at 2 years to 3.7% 4 years postoperatively. This loss was reported to be more pronounced within the first 1 to 2 years, with stability or lower progression after that time.

CONCLUSIONS:
The majority of reported complications after ICL implantation are cataract formation. The improvements in lens geometry and more accurate nomograms applied to the selection of the lens to be implanted, in addition to the surgeon’s learning curve, might be factors in the decreased occurrence of postoperative complications reported currently.
La vraie vie est ailleurs... fonction métonymique des réseaux dans quelques publicités britanniques pour le téléphone
Authors: Fries-Verdeil Marie-Hélène 
Published: June 2011

Le but de cet article est d'analyser le rôle des métonymies dans les publicités britanniques sur le téléphone portable. L'hypothèse selon laquelle les réseaux de radiotéléphonie fonctionneraient de façon métonymique plutôt que métaphorique, bien que le mot réseau soit issu d'une métaphore textile, est appliquée à trois publicités britanniques sur le téléphone portable, datant de juin 1998. Avec la firme Orange, la métonymie apparaît comme constitutive de l'expérience téléphonique. La filiale de British Telecom spécialisée dans les téléphones mobiles, Cellnet, a choisi de jouer sur les tarifs, et d'énumérer toutes les économies que sa formule « First for Families » rend possible. La communication est alors métonymiquement représentée par son coût. L'entreprise Vodafone a clairement mis en valeur un glissement métonymique de la connexion physique au lien social dans sa publicité pour les conversations au tarif de deux pence par minute en faisant se succéder trois scènes riches, sans y inclure l'ombre d'un téléphone. On voit donc comment les publicités pour le téléphone portable fondent leur argumentaire sur différents niveaux de métonymies, du réseau de télécommunications aux réseaux sociaux, en passant par des réseaux économiques.
Activated Microglia Are Less Vulnerable to Hemin Toxicity due to Nitric Oxide-Dependent Inhibition of JNK and p38 MAPK Activation
Authors: Cai Ying , Cho Geum-Sil , Ju Chung , Wang Si-Ling , Ryu Jong Hoon , Shin Chan Young , Kim Hee-Sun , Nam Kung-Woo , Jalin Angela M. A. Anthony , Sun Woong , Choi In-Young , Kim Won-Ki 
Published: June 2011

Abstract
In intracerebral hemorrhage, microglia become rapidly activated and remove the deposited blood and cellular debris. To survive in a harmful hemorrhagic or posthemorrhagic condition, activated microglia must be equipped with appropriate self-defensive mechanism(s) to resist the toxicity of hemin, a component released from damaged RBCs. In the current study, we found that activation of microglia by pretreatment with LPS markedly reduced their vulnerability to hemin toxicity in vitro. Similarly, intracorpus callosum microinjection of LPS prior to hemin treatment reduced the brain tissue damage caused by hemin and increased microglial density in the penumbra in rats. LPS induced the expressions of inducible NO synthase (iNOS) and heme oxygenase (HO)-1, the rate-limiting enzyme in heme degradation in microglia. The preventive effect by LPS was significantly diminished by an iNOS inhibitor, L-N6-(1-iminoethyl)lysine, whereas it was mimicked by a NO donor, diethylamine-NONOate, both suggesting the crucial role of NO in the modulation of hemin-induced toxicity in activated microglia. We further found that NO reduced hemin toxicity via inhibition of hemin-induced activation of JNK and p38 MAPK pathways in microglia. Whereas HO-1 expression in LPS-stimulated microglia was markedly blocked by L-N6-(1-iminoethyl)lysine, the HO-1 inhibitor, tin protoporphyrin, increased iNOS expression and decreased the susceptibility of LPS-activated microglia to hemin toxicity. The data indicate that the mutual interaction between NO and HO-1 plays a critical role in modulating the adaptive response of activated microglia to hemin toxicity. Better understanding of the survival mechanism of activated microglia may provide a therapeutic strategy to attenuate the devastating intracerebral hemorrhagic injury.
Processing of HEBP1 by Cathepsin D Gives Rise to F2L, the Agonist of Formyl Peptide Receptor 3
Authors: Devosse Thalie , Dutoit Raphaël , Migeotte Isabelle , De Nadai Patricia , Imbault Virginie , Communi David , Salmon Isabelle , Parmentier Marc 
Published: June 2011

Abstract
The peptide F2L was previously characterized as a high-affinity natural agonist for the human formyl peptide receptor (FPR) 3. F2L is an acetylated 21-aa peptide corresponding with the N terminus of the intracellular heme-binding protein 1 (HEBP1). In the current work, we have investigated which proteases were able to generate the F2L peptide from its precursor HEBP1. Structure–function analysis of F2L identified three amino acids, G3, N7, and S8, as the most important for interaction of the peptide with FPR3. We expressed a C-terminally His-tagged form of human HEBP1 in yeast and purified it to homogeneity. The purified protein was used as substrate to identify proteases generating bioactive peptides for FPR3-expressing cells. A conditioned medium from human monocyte-derived macrophages was able to generate bioactivity from HEBP1, and this activity was inhibited by pepstatin A. Cathepsin D was characterized as the protease responsible for HEBP1 processing, and the bioactive product was identified as F2L. We have therefore determined how F2L, the specific agonist of FPR3, is generated from the intracellular protein HEBP1, although it is unknown in which compartment the processing by cathepsin D occurs in vivo.
The Tuberous Sclerosis Complex–Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells
Authors: Wu Qi , Liu Yu , Chen Chong , Ikenoue Tsuneo , Qiao Yu , Li Chi-Shan , Li Weiquan , Guan Kun-Liang , Liu Yang , Zheng Pan 
Published: June 2011

Abstract
Naive T cells receive stimulation from the positive selecting ligand in the periphery for their survival. This stimulation does not normally lead to overt activation of T cells, as the T cells remain largely quiescent until they receive either antigenic or lymphopenic stimuli. The underlying mechanism responsible for survival and quiescence of the naive T cells remains largely unknown. In this study, we report that T cell-specific deletion of Tsc1, a negative regulator of mammalian target of rapamycin, resulted in both spontaneous losses of quiescence and cellularity, especially within the CD8 subset. The Tsc1-deficient T cells have increased cell proliferation and apoptosis. Tsc1 deletion affects the survival and quiescence of T cells in the absence of antigenic stimulation. Loss of quiescence but not cellularity was inhibited by rapamycin. Our data demonstrate that tuberous sclerosis complex–mammalian target of rapamycin maintains quiescence and survival of T cells.
M2 Macrophages Induced by Prostaglandin E2 and IL-6 from Cervical Carcinoma Are Switched to Activated M1 Macrophages by CD4+ Th1 Cells
Authors: Heusinkveld Moniek , de Vos van Steenwijk Peggy J. , Goedemans Renske , Ramwadhdoebe Tamara H. , Gorter Arko , Welters Marij J. P. , van Hall Thorbald , van der Burg Sjoerd H. 
Published: June 2011

AbstractMonocytes attracted by tumor-induced chronic inflammation differentiate to APCs, the type of which depends on cues in the local tumor milieu. In this work, we studied the influence of human cervical cancer cells on monocyte differentiation and showed that the majority of cancer cells either hampered monocyte to dendritic cell differentiation or skewed their differentiation toward M2-like macrophages. Blocking studies revealed that M2 differentiation was caused by tumor-produced PGE2 and IL-6. TGF-β, IL-10, VEGF, and macrophage colony-stimulating factor did not play a role. Notably, these CD14+CD163+ M2 macrophages were also detected in situ. Activation of cancer cell-induced M2-like macrophages by several TLR-agonists revealed that compared with dendritic cells, these M2 macrophages displayed a tolerogenic phenotype reflected by a lower expression of costimulatory molecules, an altered balance in IL-12p70 and IL-10 production, and a poor capacity to stimulate T cell proliferation and IFN-γ production. Notably, upon cognate interaction with Th1 cells, these tumor-induced M2 macrophages could be switched to activated M1-like macrophages that expressed high levels of costimulatory molecules, produced high amounts of IL-12 and low amounts of IL-10, and acquired the lymphoid homing marker CCR7. The effects of the interaction between M2 macrophages and Th1 cells could partially be mimicked by activation of these APCs via CD40 in the presence of IFN-γ. Our data on the presence, induction, and plasticity of tumor-induced tolerogenic APCs in cervical cancer suggest that tumor-infiltrated Th1 cells can stimulate a tumor-rejecting environment by switching M2 macrophages to classical proinflammatory M1 macrophages.
Surfaces of Rotation with Constant Mean Curvature in the Direction of a Unitary Normal Vector Field in a Randers Space
Authors: Carvalho T. M. M. , Moreira H. N. , Tenenblat K. 
Published: June 2011

AbstractWe consider the Randers space (Vn, Fb) obtained by perturbing the Euclidean metric by a translation, Fb = α + β, where α is the Euclidean metric and β is a 1-form with norm b, 0 ≤ b < 1. We introduce the concept of a hypersurface with constant mean curvature in the direction of a unitary normal vector field. We obtain the ordinary differential equation that characterizes the rotational surfaces (V3, Fb) of constant mean curvature (cmc) in the direction of a unitary normal vector field. These equations reduce to the classical equation of the rotational cmc surfaces in Euclidean space, when b = 0. It also reduces to the equation that characterizes the minimal rotational surfaces in (V3, Fb) when H = 0, obtained by M. Souza and K. Tenenblat. Although the differential equation depends on the choice of the normal direction, we show that both equations determine the same rotational surface, up to a reflection. We also show that the round cylinders are cmc surfaces in the direction of the unitary normal field. They are generated by the constant solution of the differential equation. By considering the equation as a nonlinear dynamical system, we provide a qualitative analysis, for . Using the concept of stability and considering the linearization around the single equilibrium point (the constant solution), we verify that the solutions are locally asymptotically stable spirals. This is proved by constructing a Lyapunov function for the dynamical systemand by determining the basin of stability of the equilibrium point. The surfaces of rotation generated by such solutions tend asymptotically to one end of the cylinder.