bluuebunny/crossref_metadata_2025_split huggingface dataset:
Women at Work: An International Perspective on the Interconnected Forces of Human Development, Female Education, and Labour Force Participation
Authors: Silva Malsha , Jayathilaka Ruwan , Peter Suren 
Published: June 2024

Abstract

The purpose of this study was to investigate the effects of the Human Development Index (HDI) and Tertiary School Enrolment Rate of Female (TSEF) on Female Labour Force Participation (FLPR) globally and by continent. Secondary data on sixty countries, including nine African countries, 18 Asian countries, 27 European countries, two North American countries, and four South American countries, were examined between 2000 and 2020. The Panel regression model was used to investigate the regional impact, and the Multiple Linear regression model was used to investigate the country-specific impact. The study found that HDI and TSEF are two significant factors influencing FLPR. When country-specific results were considered, the effect of each variable on FLPR revealed mixed results, with positive and negative impacts based on the characteristics of the selected country. The findings offer an in-depth understanding of how HDI and TSEF affect FLPR, which will aid policy makers in establishing and amending strategies to accelerate women's employment and, consequently, economics growth. This study focused on the HDI and TSEF variables that were rarely used in existing literature together on FLPR.
Clinical efficacy of CRN’s three-stage approach for the treatment of infected neuropathic diabetic foot：a retrospective study
Authors: Dong Qiang , Zuo Zhicheng , Li Qing , Zhu Zhenhua , Zhou Kailong 
Published: June 2024

Abstract

Background
Currently, clearing infections and repairing wounds are the main treatment for diabetic foot. However, statistics indicate that most cases of diabetic foot are caused by neuropathy alone or combined with vascular disease. In such cases, follow-up Neurotherapy plays a crucial role in managing diabetic foot patients. This study aimed to investigate the efficacy of using the CRN’s (Control infection, C; Repair wound, R; Neurolysis, N) three-stage approach in treating infected neuropathic diabetic foot.
Methods
A retrospective analysis was conducted on 84 diabetic foot patients with infection, ulceration, local gangrene, and neuropathy who were admitted to the Second Affiliated Hospital of Soochow University between March 2019 and March 2022. The treatment protocol involved complete surgical debridement in the first stage, wound repair surgery in the second stage, and the performance of Dellon triple neurolysis treatment three months after complete wound healing. The rate of foot sensory relief and the change of two-point discernment were compared before and after the operation.
Results
Following the operations, out of the 84 diabetic foot patients, 3 patients were treated with amputation due to progressive aggravation of infection and necrotizing fasciitis, while 81 underwent stages 2 and 3 of the treatment. Over an 8–18 months follow-up period, 3 patients were lost to follow-up, leaving 78 patients for analysis. Among them, 70 patients experienced successful wound healing without diabetic foot recurrence after the three-stage treatment, leading to successful limb preservation. 6 patients had diabetic foot recurrence but were readmitted for further treatment, resulting in successful wound repair and limb preservation. 2 patients passed away due to complications. Post-operation, neurologic symptoms improved in 76 patients who were followed up successfully, with a 95.9% foot sensory relief rate three months after the surgery, indicating positive outcomes. Additionally, two-point discrimination significantly improved three months post-surgery compared to pre-surgery levels, with statistical significance (P < 0.01).
Conclusion
The CRN’s three-stage surgical approach proves to be an effective method for treating infected neuropathic diabetic foot. It can shorten the hospital stay, regulate the treatment course, improve the limb-saving rate, and reduce the recurrence of diabetic foot.
Joint action over Zoom: Assessing corepresentation with remote task partners using the joint Simon task
Authors: Sobel Briana M , Sims Valerie K 
Published: June 2024

Abstract

Joint action, or multiple people working together to achieve a shared goal, is a common part of everyday life. Due to an advancing workplace and accelerated in part due to the COVID-19 pandemic, more collaborative work is being conducted remotely. To help investigate the differences in joint action between in-person and remote settings, the current study used a perceptual cognitive reaction time task known as the joint Simon task. The joint Simon task assesses spatial compatibility effects, such that partners sitting side-by-side respond faster to targets that appear on the side compatible to their response (e.g., left participant/left target) than on the side incompatible to their response (e.g., left participant/right target). The spatial compatibility effect is commonly used to measure self-other integration and corepresentation between task partners. Participants completed a joint Simon task and a go/no-go task (i.e., a joint Simon task with no partner) remotely online via the videoconferencing application Zoom. The remote task partner was either the experimenter (Experiment 1) or a confederate participant (Experiment 2). Both experiments found no spatial compatibility effect when completing a task remotely with a partner but did show social facilitation through faster reaction times when completing the task with a partner vs alone. Additionally, both experiments found a spatial compatibility effect when completing the go/no-go task alone, a finding contradictory to previous literature. Overall, these findings indicate that working remotely with a partner can influence performance, but self-other integration and corepresentation of partners’ actions may be impaired when collaborating remotely.
Feasibility of a Home-Base Home Videogaming Intervention with a Family-Centered Approach for Children with Cerebral Palsy: A Randomized Multiple Baseline Single-Case Experimental Design
Authors: Chan-Víquez Daniela , Fernández-Huertas Heilyn , Montserrat-Gonzalez Carles , Khan Ajmal , Fehlings Darcy , Munce Sarah , Wright F. Virginia , Biddiss Elaine 
Published: June 2024

Abstract

Background
Worldwide, children with cerebral palsy (CP) living in underserved communities face barriers to accessing motor therapy services. This study assessed the implementation and effectiveness of an 8-week, upper limb (UL) home-based intervention with a movement-tracking videogame (Bootle Blast) in Costa Rican children with CP.
Methods
Children established a weekly playtime goal and two UL activities of daily living (ADLs) that they would like to improve on. A multiple-baseline, single-case experimental design, was used with the Performance Quality Rating Scale (PQRS) as the repeated measure to track changes in performance of the selected ADLs between the baseline (usual care) and intervention (Bootle Blast) phases. The Canadian Occupational Performance Measure (COPM), the Box and Blocks Test (BBT) and the Children’s Hand-use Experience Questionnaire (CHEQ) were collected before and after the intervention. Technical barriers were documented during weekly video calls with a monitoring therapist. Treatment effect size, slope changes and percentage of non-overlapping data were identified for the PQRS. Descriptive statistics summarized results for the BBT, CHEQ, videogame logs (e.g., playtime) and technical barriers.
Results
Fifteen children participated and 13 completed the intervention. Both participants who dropped out did so after completing baseline assessments, but before experiencing Bootle Blast. Children’s mean active playtime (i.e., mini-games targeting the UL) across the 8-weeks was 377 minutes, while mean total time spent engaging with Bootle Blast (active + passive play time [e.g., time navigating menus, reviewing rewards]) was 728 minutes. In total, eight technical issues (from 5 children) were reported, and all but three were resolved within 48 hours. Partial effectiveness was associated with the intervention. Specifically, 85% of participants improved on the PQRS and 69% achieved clinically important improvements ≥ 2 points in performance on the COPM. Children improved by 1.8 blocks on average on the BBT, while on the CHEQ, five children had a clinically important increase of 10% of the total number of UL activities performed with both hands.
Conclusion
Bootle Blast is a feasible and effective option to facilitate access and engage children with cerebral palsy in UL home rehabilitation.
Trial registration number
NCT05403567.
Olaparib enhancing radiosensitization and anti-metastatic effect of oral cancer by targeting IL-17A signal
Authors: Yu Chih-Chia , Lin Hon-Yi , Chan Michael W.Y. , Wu Shu-Fen , Chiou Wen-Yen , Lee Moon-Sing , Chi Chen-Lin , Lin Ru-Inn , Hsu Feng-Chun , Yang Hsuan-Ju , Chen Liang-Cheng , Chew Chia-Hui , Hung Shih-Kai 
Published: June 2024

Abstract

Purpose
We tested whether the PARP inhibitor, Olaparib, can effectively enhance radiosensitivity while inhibiting OSCC growth and metastasis in vitro and in vivo. Patient samples were used for survival validation.
Methods
The present study investigated the effect of Olaparib and ionizing radiation (IR) on clonogenic, migratory, and invasive ability in human IR-sensitive (OML1) and IR-resistant (OML1-R) OSCC cell lines. We next explored the underlying mechanism with ELISA and a Western blotting assay. Two in vivo mouse models were established to investigate the efficacy of Olaparib combined with radiotherapy (RT) on local tumor growth and lung metastasis. IL-17A expression was confirmed in tissue specimens of OSCC patients by immunohistochemistry.
Results
We found that Olaparib, in combination with IR, substantially inhibited cell growth, migration, and invasion in vitro. Mechanistically, the Olaparib treatment significantly reduced the secretion of IL-17A in irradiated OSCC cells by attenuating NF-κB and p38 activity. Consistently, Olaparib enhanced the radiosensitivity and, with RT, synergistically reduced both tumor growth and lung metastasis in mice. In addition, OSCC patients with high IL-17A expression were substantially associated with an increased risk of lymph node involvement and worse survival.
Conclusions
This study has highlighted that Olaparib displays radiosensitizing and antimetastatic effects by inhibiting the IL-17A-dependent signal. Remarkably, Olaparib could provide a remarkable anticancer efficacy to improve treatment response in OSCC patients with recurrent/metastatic disease after RT.
Construction of a Logistic-regression risk-based prediction model for hospital infection in obstetric inpatients
Authors: Huang Lei , Wu Jielong , Huang Huiping , Chen Houzhi , Ran Jing 
Published: June 2024

Abstract

Objective
This study aimed to establish a risk prediction model for hospital infection among hospitalized pregnant women in the obstetrics department of a general hospital, providing a theoretical basis for predicting and reducing infection risks.
Methods
Inpatients from a General hospital from January 2017 to December 2021 served as the training dataset. The dataset included 273 cases with nosocomial infections and 24,182 without. Logistic regression was used to analyze infection risk factors and construct the prediction model. An external validation dataset consisted of 4,153 pregnant women admitted in 2022, with predictive efficiency analyzed using a receiver operating characteristic curve.
Results
Logistic regression identified several factors increasing nosocomial infection risks: cesarean section, gestational week < 37, long hospital stays, prenatal anemia, prenatal hypoproteinemia, adverse birth outcomes, surgery, and intubation (central vein and urinary). The constructed column graph, based on the logistic model, predicted infection risks. ROC curve analysis showed that the area under the curve (AUC) for the prediction model was 0.827 (0.805, 0.849) in the training set and 0.841 (0.768, 0.913) in the validation set.
Conclusion
The study constructed and validated a nosocomial infection risk prediction model for hospitalized pregnant women in obstetrics. Its clinical application can facilitate early identification of high-risk groups, enabling timely infection prevention and control measures. And also provides a reference for screening and effective nursing interventions.
Spatial analysis of the potential impact of contaminated areas on wells and aquifers in the Upper Tietê Basin, São Paulo, Brazil
Authors: de Camargo Ana Carolina Medeiros , Moreira Rodrigo Nehara , Leite Claudio Baptista  Benedito , Vasconcelos Vitor Vieira 
Published: June 2024

Abstract

Upper Tietê stands out as the basin with the highest concentration of contaminated areas in São Paulo, Brazil, thereby exerting a pronounced impact on the quality of groundwater and directly affecting the resident population. Recognizing the importance of developing indicators for effective aquifer management, this study proposed to identify and assess the degree of risk, vulnerability, and contamination of aquifers and wells in the Upper Tietê Basin. Were applied the Aquifer Vulnerability Index method to evaluate the aquifer vulnerability in the region; the delimitation of safety perimeters and identification of wells at risk; and the integrated risk index, unifying information on social and aquifer vulnerabilities, hazards and exposure. The results reveal that the aquifers have a high vulnerability, mainly due to the thickness of their unsaturated layer. Furthermore, there were 7,958 wells at risk around the basin (77.15%), and the most vulnerable municipalities are on the outskirts of the basin. This study provides important insights, mainly due to the holistic approach, serving as a basis for identifying the regions with the highest risks, which can be prevented and mitigated with appropriate actions.
Serum Copper to Zinc Ratio and Risk of Endometriosis: Insights from a Case-Control Study
Authors: Liu Yanping , Cheng Guihong , Li Hong , Meng Qingxia 
Published: June 2024

Abstract

The significance of trace metal elements in the development of endometriosis has garnered increasing interest. We aimed to investigate the relationship between serum copper (Cu), zinc (Zn), iron (Fe), magnesium (Mg) levels, and the Cu/Zn ratio with the risk of endometriosis. This study involved 568 infertile patients diagnosed with endometriosis, compared to 819 infertile patients without endometriosis (Control group). Basic characteristics, hormonal parameters, and essential trace elements of the patients were measured and analyzed. The findings indicated a notable decrease in serum Zn levels in the endometriosis group compared to controls, alongside a significant increase in the Cu/Zn ratio (P < 0.001). Restricted cubic spline analysis (RCS) revealed a linear relationship between Zn levels and the Cu/Zn ratio with the risk of endometriosis. Moreover, Zn levels exhibited a negative correlation with endometriosis risk (P trend = 0.005), while the Cu/Zn ratio displayed a positive correlation with endometriosis risk, even after adjusting for age, body mass index (BMI), and baseline hormones (P trend < 0.001). Compared to the first quartile of Cu/Zn ratio after adjustment, the odds ratios (ORs) with 95% confidence intervals (CIs) for the second and fourth quartiles were 1.97 (1.37, 2.83) and 2.63 (1.80, 3.84), respectively. This study provided evidence of decreased serum Zn levels and increased Cu/Zn ratio being associated with an elevated risk of endometriosis among infertile patients.
Enhancing Educational and Tourism Applications through Predictive Modeling of Cultural Heritage Site Visitation: use of Arima and autoregressive models
Authors: Rosser Pablo , Soler Seila 
Published: June 2024

Abstract

This study focuses on the use of ARIMA and Autoregressive (AR) models to predict visitor flow to Civil War shelters in Alicante, highlighting seasonal patterns and differences among various visitor groups, with an enriching approach towards educational and tourism applications. Through a retrospective longitudinal design covering from August 2023 to January 2024, it analyzes the time series of visits, differentiating between the general public and school groups, as well as examining geographical demand. The research emphasizes the effectiveness and simplicity of the ARIMA(0, 0, 0) model with Logarithmic Transformation in modeling time series, while the AR(6) model proves indispensable for capturing short-term temporal dependencies. Despite the usefulness of these forecasts for future planning, the existence of uncertainties highlights the importance of adopting flexible management approaches and incorporating additional variables to refine predictions. This approach not only improves the management of visitor flows but also significantly contributes to the creation of more effective educational and tourism strategies, promoting the sustainability and appreciation of cultural heritage.
Introducing accessible digestion methods that best capture the macro-, micro- and toxic element contents of some almond kernels
Authors: Ahmed Isam Ali Mohamed , Al-Juhaimi Fahad , Özcan Mehmet Musa , Uslu Nurhan , Albakry Zainab 
Published: June 2024

Abstract

The highest K and S were detected in almond samples burned with HCL acid. In addition, the highest levels of Ca (5162.43 mg/kg), Mg (4568.75 mg/kg) and P (7.02 mg/kg) were detected in the samples burned in the muffle furnace and by the wet burning method, respectively. Macro element contents of almond samples obtained as a result of burning in HCL and muffle furnace were high. Depending on the almond varieties and burning methods, the microelement detected in the highest levels was Mn, followed by Zn, Fe, B and Cu in decreasing order. The highest Fe content was detected in the almonds burned by the wet burning method, followed by muffle furnace, HCL burning and microwave burning in decreasing order. The highest Mn was detected in almonds burned by the wet burning method, followed by burning in a muffle furnace (dry ash), burning with HCl and burning in a microwave in decreasing order. The overall average As content of almond samples burned with different burning methods was highest in the sample burned with HCL (2110.68 mg/kg), and followed by muffle furnace (1455.12 mg/kg), microwave (729.16 mg/kg) and wet burning (481.85 mg/kg) methods in decreasing order. As a result, according to the combustion methods, the highest amounts of elements were detected in the samples combusted with HCL, followed by wet combustion, muffle furnace and microwave combustion methods in decreasing order.
Stability of Homomorphisms, Coverings and Cocycles I: Equivalence
Authors: Chapman Michael , Lubotzky Alexander 
Published: June 2024

Abstract

This paper is motivated by recent developments in group stability, high dimensional expansion, local testability of error correcting codes and topological property testing. In Part I, we formulate and motivate three stability problems:
• Homomorphism stability: Are almost homomorphisms close to homomorphisms?
• Covering stability: Are almost coverings of a cell complex close to genuine coverings of it?
• Cocycle stability: Are 1-cochains whose coboundary is small close to 1-cocycles?
We then prove that these three problems are equivalent.
In Part II of this paper [CL23], we present examples of stable (and unstable) complexes, discuss various applications of our new perspective, and provide a plethora of open problems and further research directions. In another companion paper [CP23], we study the stability rates of random simplicial complexes in the Linial–Meshulam model.
Ferrocyanide Surface Ligands to Quantum Dots for Prussian Blue Composites Showing Efficient and Reversible Electrochemical Response
Authors: Ha Taeyong , Sung Yunmo , Kwon Yongju , Choi Sukyung , Jin Ho , Kim Sungjee 
Published: June 2024

Abstract

We employed a novel approach to fabricate quantum dot-in-Prussian blue analogue (QD-in-PBA) composites, encapsulating colloidal QDs into the electrical conducting metal organic framework PBA, which could provide a robust platform for efficient photochemical modulation of photoluminescence (PL) intensity. To achieve this, the surface of the QDs was engineered by attaching ferrocyanide ligands. This surface modification enabled the QDs to be seamlessly and uniformly incorporated into the PBA matrix. The ferrocyanide ligands on the QD surfaces played a pivotal role in initiating the in-situ formation of PBA, facilitated by the introduction of additional ferrocyanide ions and iron (III) ions as the building blocks of PBA. Alternatively applied external voltages to the QD-in-PBA electrode within an electrochemical cell demonstrated the reversible quenching and recovery of the PL intensity of the QDs embedded within the QD-in-PBA composite. Notably, we achieved the on/off modulation ratio over 7, which could be consistently repeated across multiple cycles. In contrast, the control sample, comprising a mixture of QDs and PBA, exhibited poor stability in terms of electrochemical performance, with a reduced modulation degree observed over repeating cycles. This diminished stability can be attributed to the fact that in the control sample, the QDs were merely attached to the surface of the PBA rather than being fully incorporated within the matrix and became redispersed into the electrolyte solution during the electrochemical reactions.
Overcoming N-glycosylation challenges through multiplex CRISPR/Cas9-mediated editing of seven glycosyltransferase homologs in Nicotiana benthamiana
Authors: Kaur Chetan , Song Hayoung , Lee Myungjin , Kim Seo-Young , Seo Dong-Hoon , Kang Hyangju , Sohn Eun-Ju , Ran Yidong , Koo Okjae , Lee Geung-Joo 
Published: June 2024

Abstract

Utilizing plants for the manufacturing of therapeutic drugs for human and animal disease treatment faces technical and regulatory challenges because of disparities in the N-glycosylation pathway between animals and plants. The key challenge involves differences in the post-translational modification machinery in the N-glycosylation pathway. We used multiplex CRISPR/Cas9 genome editing to target five α-1,3-fucosyltransferase and two β-1,2-xylosyltransferase genes to modify N-glycosylation in Nicotiana benthamiana. We obtained two T0 transformants, HL40 and HL64, which exhibited successful mutagenesis in all seven target genes. Mutations in these genes resulted from deletions ranging from a single base to up to 26 bases, and single-base insertions. In subsequent generations, stable Cas9-free homozygous lines exhibiting mutations in all seven genes were identified. Three Cas9-free T1 transformants with the highest number of homozygous mutations were selected to generate T2 transformants. Heterozygous alleles in the T1 transformants segregated into homozygous genotypes in the T2 generation with a confirmed loss of enzyme activity. The morphology and growth rate of the T2 transformants showed no notable variations compared to those of the wild type throughout germination, flowering, and seed production, indicating the absence of discernible side effects from the mutations. Our experiment yielded 12 Cas9-free, glycoengineered, homozygous plants suitable for plant-based recombinant protein production in molecular farming systems, eliminating regulatory and immunogenic concerns.