bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attenuated responses to emotional expressions in women with generalized anxiety disorder
Authors: Palm M. E. , Elliott R. , McKie S. , Deakin J. F. W. , Anderson I. M. 
Published: August 2010

BackgroundGeneralized anxiety disorder (GAD) is under-researched despite its high prevalence and large impact on the healthcare system. There is a paucity of functional magnetic resonance imaging (fMRI) studies that explore the neural correlates of emotional processing in GAD. The present study investigated the blood oxygen level dependent (BOLD) response to processing positive and negative facial emotions in patients with GAD.MethodA total of 15 female GAD patients and 16 female controls undertook an implicit face emotion task during fMRI scanning. They also performed a face emotion recognition task outside the scanner.ResultsThe only behavioural difference observed in GAD patients was less accurate detection of sad facial expressions compared with control participants. However, GAD patients showed an attenuated BOLD signal in the prefrontal cortex to fearful, sad, angry and happy facial expressions and an attenuated signal in the anterior cingulate cortex to happy and fearful facial expressions. No differences were found in amygdala response.ConclusionsIn contrast with previous research, this study found BOLD signal attenuation in the ventrolateral and medial prefrontal cortex and the anterior cingulate cortex during face emotion processing, consistent with a hypothesis of hypo-responsivity to external emotional stimuli in GAD. These decreases were in areas that have been implicated in emotion and cognition and may reflect an altered balance between internally and externally directed attentional processes.
Universal prevention of depression in women postnatally: cluster randomized trial evidence in primary care
Authors: Brugha T. S. , Morrell C. J. , Slade P. , Walters S. J. 
Published: August 2010

BackgroundTo test whether receiving care from a health visitor (HV) trained in identification and psychological intervention methods prevents depression 6–18 months postnatally in women who are not depressed 6 weeks postnatally.MethodThe study was a prospective cluster trial, randomized by GP practice, with follow-up for 18 months in 101 primary care teams in the Trent area of England. The participants were women scoring <12 on the postal Edinburgh Postnatal Depression Scale (EPDS) at 6 weeks postnatally (1474 intervention and 767 control women). Intervention HVs (n=89, 63 clusters) were trained in identifying depressive symptoms using the EPDS and face-to-face clinical assessment and in providing psychologically orientated sessions based on cognitive behavioral or person-centered principles. The control group comprised HVs (n=49, 37 clusters) providing care as usual (CAU). The primary outcome measure was the proportion of women scoring ⩾12 on the EPDS at 6 months postnatally. Secondary outcomes were mean EPDS score, Clinical Outcomes in Routine Evaluation – Outcome Measure (CORE-OM) score, State–Trait Anxiety Inventory (STAI), 12-item Short Form Health Survey (SF-12) and Parenting Stress Index Short Form (PSI-SF) scores at 6, 12 and 18 months.ResultsAfter adjusting for individual-level covariates, living alone, previous postnatal depression (PND), the presence of one or more adverse life events and the 6-week EPDS score, the odds ratio (OR) for EPDS ⩾12 at 6 months was 0.71 [95% confidence interval (CI) 0.53–0.97, p=0.031] for the intervention group (IG) women compared with the control (CAU) group women. Two subgroups were formed by baseline severity: a ‘subthreshold’ subgroup with a 6-week EPDS score of 6–11 (n=999) and a ‘lowest severity’ subgroup with a 6-week EPDS score of 0–5 (n=1242). There was no difference in psychological effectiveness by subgroup (interaction term: z=−0.28, p=0.782).ConclusionsThis study provides new evidence of a universal, enduring preventive effect for depression in women who screen negative for depression postnatally.
Enregistering internet language
Authors: Squires Lauren 
Published: August 2010

AbstractThis article investigates the enregisterment of an internet-specific language variety and its features. The enregisterment of internet language is explored through several sites of metadiscourse: academic scholarship about computer-mediated communication, uses of the metalinguistic termsnetspeakandchatspeakin print media, and online comment threads about language and the internet. This metadiscourse provides evidence of a shared concept of internet language as comprising distinctive written features, primarily acronyms, abbreviations, and respellings. Internet language's enregisterment emerges from standard language ideology and deterministic views of technology, where the construal of these features as both nonstandard and internet-specific articulates the perceived distinctiveness of internet interactions. Yet empirical evidence shows that these features are relatively rare in instant messaging conversations, one form of interaction to which internet language is attributed; this discrepancy has implications for the application of indexical order to enregisterment. (Enregisterment, language ideology, computer-mediated communication, internet, metadiscourse, indexical order, Standard English, technological determinism, mass media)*
Five centuries of Latin American income inequality
Authors: Williamson Jeffrey G. 
Published: August 2010

AbstractMost analysts of the modern Latin American economy believe that it has always had very high levels of inequality. Indeed, some have argued that high inequality appeared very early in the post-conquest Americas, and that this fact supported rent-seeking and anti-growth institutions that help explain the disappointing growth performance we observe there even today. This paper argues to the contrary. Compared with the rest of the world, Latin American inequality wasnothigh either in pre-conquest 1491 or in the post-conquest decades following 1492. Indeed, it wasnoteven high in the mid-19thcentury just before Latin America’sbelle époque. It only became high thereafter. Historical persistence in Latin American inequality is a myth.
Colonial Origins of Inequality in Hispanic America? Some Reflections Based on New Empirical Evidence
Authors: Dobado González Rafael , García Montero Héctor 
Published: August 2010

AbstractThis paper attempts to contribute to the ongoing debate on the historical roots of the high economic inequality of contemporary Iberian America. Our approach, which is basically empirical, departs from the mainstream scholarship. We show new data on wages and heights in several viceroyalties that (1) suggest relatively medium-to-high levels of material welfare among the commoners in Bourbon Hispanic America; and (2) allow us to build indexes of economic inequality. An international comparison of those indexes casts some doubts on the widely accepted view that Viceroyal America’s economy was exclusively based on extremely unequal or extractive institutions, as it has been popularized by the influential works by Engerman and Sokoloff and Acemogluet al.
Between the colonial heritage and the first globalization boom: on income inequality in the Southern Cone
Authors: Bértola Luis , Castelnovo Cecilia , Rodríguez Javier , Willebald Henry 
Published: August 2010

AbstractThis paper presents a first estimate of income inequality in the Southern Cone of South America (Brazil 1872 and 1920, Chile 1870 and 1920, Uruguay 1920) and some assumptions with regard to Argentina (1870 and 1920) and Uruguay (1870). We find that income distribution was relatively high on the eve of the first globalization boom. Thus, inequality is not only the result of globalization, but also a structural feature. Inequality increased between 1870 and 1920, both within individual countries and between countries. Globalization forces do not result in obvious outcomes. Rather, the effect of globalization on inequality depends on the expansion of the frontier and institutional persistence and change in old and new areas. Inequality was clearly high in the wake of the globalization process. This was a particular kind of inequality, which was part of a set of institutions closely linked to the exports of primary goods, sluggish technological change and limited human capital formation.
The Presumption of Guilt and the English Law of Theft, 1750–1850
Authors: Smith Bruce P. 
Published: August 2010

When it is said that a defendant to a criminal charge is presumed to be innocent, what is really meant is that the burden of proving his guilt is upon the prosecution. This golden thread…runs through the web of the English criminal law. Unhappily Parliament regards the principle with indifference—one might almost say with contempt. The statute book contains many offences in which the burden of proving his innocence is cast on the accused.No principle in Anglo-American criminal law is more vaunted than the so-called “presumption of innocence”: the doctrine that the prosecution must bothproduceevidence of guilt andpersuadethe fact-finder “beyond a reasonable doubt.” The claim that “every man is presumed to be innocent until he is proved guilty” has been described as “dear to the hearts of Englishmen” and as an omnipresent feature of English criminal law. In 1895, the United States Supreme Court declared the “presumption of innocence in favor of the accused” to be “the undoubted law, axiomatic and elementary”—a protection that “lies at the foundation of the administration of our criminal law.” Befitting its lofty stature in Anglo-American legal culture, the presumption has become associated, over time, with that most famous of Blackstonean maxims: “[I]t is better that ten guilty persons escape, than that one innocent suffer.”
Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII
Authors: Llácer José L. , Espinosa Javier , Castells Miguel A. , Contreras Asunción , Forchhammer Karl , Rubio Vicente 
Published: August 2010

PII, an ancient and widespread signaling protein, transduces nitrogen/carbon/energy abundance signals through interactions with target proteins. We clarify structurally how PII regulates gene expression mediated by the transcription factor NtcA, the global nitrogen regulator of cyanobacteria, shedding light on NtcA structure and function and on how NtcA is activated by 2-oxoglutarate (2OG) and coactivated by the nonenzymatic PII target, protein PipX. We determine for the cyanobacteria
Synechococcus elongatus
the crystal structures of the PII–PipX and PipX–NtcA complexes and of NtcA in active and inactive conformations (respective resolutions, 3.2, 2.25, 2.3, and 3.05 Å). The structures and the conclusions derived from them are consistent with the results of present and prior site-directed mutagenesis and functional studies. A tudor-like domain (TLD) makes up most of the PipX structure and mediates virtually all the contacts of PipX with PII and NtcA. In the PII–PipX complex, one PII trimer sequesters the TLDs of three PipX molecules between its body and its extended T loops, preventing PipX activation of NtcA. Changes in T loop conformation triggered by 2OG explain PII–PipX dissociation when 2OG is bound. The structure of active dimeric NtcA closely resembles that of the active cAMP receptor protein (CRP). This strongly suggests that with these proteins DNA binding, transcription activation, and allosteric regulation occur by common mechanisms, although the effectors are different. The PipX–NtcA complex consists of one active NtcA dimer and two PipX monomers. PipX coactivates NtcA by stabilizing its active conformation and by possibly helping recruit RNA polymerase but not by providing extra DNA contacts.
Assessment of individual anaerobic threshold and stroking parameters in swimmers aged 10–11 years
Authors: Fernandes Ricardo J. , Sousa Marisa , Pinheiro Armindo , Vilar Sonia , Colaço Paulo , Vilas‐Boas J. Paulo 
Published: August 2010

AbstractThe assessment of blood lactate concentration is considered essential for the physiological diagnosis of swimming performance. But for a more detailed and complete analysis of a swimmer's strengths and weaknesses, it is also important to examine his or her technical characteristics. However, few studies have combined physiological and technical evaluation in child swimmers. The aim of the present study was to assess the metabolic anaerobic threshold (blood lactate concentration and corresponding swimming velocity) of 10‐ to 11‐year‐old swimmers (n=15) using an individualized intermittent incremental protocol. Comparison was made with the traditionally used 4 mmol · l−1 lactate threshold. In addition, stroke rate, stroke length, and stroke index were measured throughout the experimental protocol for assessment of the anaerobic threshold. Each swimmer performed a front crawl 5×200 m test, in which the swimming velocity was controlled by an acoustic signal each 50 m. Blood samples were collected from the ear lobe (Lactate Pro, Arkay, Inc., Kyoto, Japan), at rest and after each step. Stroke rate was registered by a Seiko base 3 chronofrequencemeter; stroke length, stroke index, and velocity were calculated at the end of each 200 m. The individual anaerobic threshold occurred at 2.3 mmol · l−1 (s=0.59), and the corresponding velocity was 1.026 m · s−1 (s=0.053), much lower than the traditionally used 4 mmol · l−1 value (or even 3.5 mmol · l−1). The velocity corresponding to 4 mmol · l−1 and 3.5 mmol · l−1 was 1.081 m · s−1 (s=0.056) and 1.067 m · s−1 (s=0.055), respectively. Stroke rate increased and stroke length decreased throughout the incremental protocol (i.e. with increasing velocity). The stroke index showed a tendency to increase throughout the protocol, with a significant difference from the first to the second step. The velocity corresponding to 4 mmol · l−1 (and 3.5 mmol · l−1) does not represent the metabolic individual anaerobic threshold in trained swimmers, independently of their age, and age‐group swimmers prefer to increase their velocity through an increase in stroke rate. Thus, given the importance of developing swimming technique in age‐group swimmers, coaches should implement the lengthening of swimmers' stroke cycles in their training practice routines, so that they limit the effects of reduced stroke length when velocity increases.
Redox Regulation of the NPR1-TGA1 System of Arabidopsis thaliana by Nitric Oxide
Authors: Lindermayr Christian , Sell Simone , Müller Bernd , Leister Dario , Durner Jörg 
Published: August 2010

Abstract
The role of reactive oxygen and nitrogen species in local and systemic defense reactions is well documented. NPR1 and TGA1 are key redox-controlled regulators of systemic acquired resistance in plants. NPR1 monomers interact with the reduced form of TGA1, which targets the activation sequence-1 (as-1) element of the promoter region of defense proteins. Here, we report the effect of the physiological nitric oxide donor S-nitrosoglutathione on the NPR1/TGA1 regulation system in Arabidopsis thaliana. Using the biotin switch method, we demonstrate that both NPR1 and TGA1 are S-nitrosylated after treatment with S-nitrosoglutathione. Mass spectrometry analyses revealed that the Cys residues 260 and 266 of TGA1 are S-nitrosylated and S-glutathionylated even at GSNO concentrations in the low micromolar range. Furthermore, we showed that S-nitrosoglutathione protects TGA1 from oxygen-mediated modifications and enhances the DNA binding activity of TGA1 to the as-1 element in the presence of NPR1. In addition, we observed that the translocation of NPR1 into the nucleus is promoted by nitric oxide. Taken together, our results suggest that nitric oxide is a redox regulator of the NPR1/TGA1 system and that they underline the importance of nitric oxide in the plant defense response.
Recrystallization of Cu–In–S thin films studiedin situby energy-dispersive X-ray diffraction
Authors: Rodriguez-Alvarez Humberto , Mainz Roland , Marsen Björn , Abou-Ras Daniel , Schock Hans Werner 
Published: August 2010

The recrystallization of Cu–In–S thin films has been monitored in real time by means of synchrotron-based energy-dispersive X-ray diffraction. To trigger recrystallization, nanocrystalline Cu–In–S layers with [Cu]/[In] < 1 were covered with layers of CuS or pure Cu, so that the overall ratio [Cu]/[In] > 1. The bilayer films were heated to 773 K and the evolution of the microstructure was monitoredin situ viadiffraction spectra. In the first step of the analysis, the diffraction data were used to identify solid-state phase transitions as a function of temperature. In a further step, single-line profile analysis of the 112 CuInS2reflection was used to study grain growth in this material system. The recrystallization was investigated under two sulfur pressure conditions and for different [Cu]/[In] ratios. The recrystallization is composed of three steps: consumption of the CuIn5S8phase, grain growth, and a transition from the Cu–Au-type to the chalcopyrite-type structure of CuInS2. Increasing the sulfur pressure during heating systematically reduces the temperature at which grain growth sets in. Various paths to control the recrystallization of Cu–In–S thin films are proposed.
Hands and Knees Posture in Late Pregnancy or Labour for Fetal Malposition  (Lateral or Posterior)
Authors: Hofmeyr G.J. , Kulier R. 
Published: August 2010

ABSTRACTBackground:  Lateral and posterior position of the baby's head (the back of the baby's head facing to the side or the mother's back) may be associated with more painful, prolonged or obstructed labour and difficult delivery. It is possible that certain positions adopted by the mother may influence the baby's position.Objectives:  The objective of this review is to assess the effects of adopting a hands and knees maternal posture in late pregnancy or during labour when the presenting part of the fetus is in a lateral or posterior position, compared with no intervention.Search strategy:  We searched the Cochrane Pregnancy and Childbirth Group Trials Register (November 2004) and the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 4, 2004).Selection criteria:  Randomised trials of hands and knees maternal posture compared to other postures or controls.Data collection and analysis:  Both review authors assessed trial eligibility and quality.Main results:  Two trials of hands and knees posture during pregnancy were included. In one trial involving 100 women, four different postures (four groups of 20 women) were combined for the comparison with the control group of 20 women. Lateral or posterior position of the presenting part of the fetus was less likely to persist following 10 minutes in the hands and knees position compared to a sitting position (one trial, 100 women, relative risk (RR) 0.25, 95% confidence interval (CI) 0.17 to 0.37). In a second trial including 2547 women, advice to assume the hands and knees posture for 10 minutes twice daily in the last weeks of pregnancy had no effect on the baby's position at delivery or any of the other pregnancy outcomes measured. No trials of hands and knees posture during labour were included.Authors’ conclusions:  Use of hands and knees position for 10 minutes twice daily to correct occipitoposterior position of the fetus in late pregnancy cannot be recommended as an intervention. This is not to suggest that women should not adopt this position if they find it comfortable. The use of this position during labour has not been addressed in this review. In view of the promising short‐term effects of the technique and its simplicity, further trials are justified to determine whether encouraging the use of hands and knees posture during rather than before labour, has any effect on substantive outcomes.
T‐DNA tagging reveals a novel cDNA triggering cytokinin‐ and auxin‐independent protoplast division
Authors: Miklashevichs Edvins , Czaja Inge , Cordeiro Alexandra , Prinsen Els , Schell Jeff , Walden Richard 
Published: August 2010

SummaryActivation T‐DNA tagging was used to generate four cytokinin‐independent (cyi1–4) tobacco cell lines. Plants regenerated from the mutant lines displayed similar phenotypes: reduced apical dominance, poorly developed roots, delayed growth and flowering, and male and female sterility. Tissue culture experiments demonstrated that the mutations in the different lines uncouple cell proliferation from the effects of both cytokinin and auxin. No significant increase of cytokinin or auxin was found in transgenic calli in comparison with untransformed callus. The functional plant sequence tagged in one of the mutant lines, cyi1, was used to isolate an active cDNA, cyi1a, that was able to trigger cytokinin‐ and auxin‐independent protoplast division. Northern analysis shows that the transcript corresponding to cyi1a accumulates to high levels in the untransformed protoplasts shortly before the onset of cell division, and that these levels decrease when protoplasts reach maximum rates of cell division. A small putative open reading frame, starting with the first ATG in cyi1a and encoding a 22 amino acid peptide, has the same activity in tobacco protoplasts as the whole cDNA. This activity is destroyed by a frame shift mutation. Apparently cyi1a encodes a peptide which participates in the events downstream of a joint point of cytokinin and auxin action leading to cell division.
Movement and subcellular localization of a tobamovirus in Arabidopsis
Authors: Lartey Robert , Ghoshroy Soumitra , Ho Joe , Citovsky Vitaly 
Published: August 2010

SummaryTobamoviruses represent a well‐characterized system used to examine viral infection, whereas Arabidopsis is a choice plant for most genetic experiments. It would be useful to combine both approaches into one experimental system for virus‐plant interaction. Most tobamoviruses, however, are not pathogenic in Arabidopsis. Here, we describe infection of Arabidopsis by a recently discovered crucifer‐infecting turnip vein clearing tobamovirus (TVCV). Using this system, we determined patterns and kinetics of viral local and systemic movement within Arabidopsis plants. Localization studies showed that the virus infects both vegetative and reproductive plant tissues. However, there may be a transport barrier between the seed coat and the embryo which virions cannot cross, preventing seed transmission of TVCV. The ability to move both locally and systemically in Arabidopsis, causing mild and fast‐developing symptoms but allowing survival and fertility of the infected plants, distinguish TVCV infection of Arabidopsis as a model system to study virus‐plant interaction.