bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of overlaps between GERD, FD and IBS and impact on health‐related quality of life
Authors: Kaji Makiko , Fujiwara Yasuhiro , Shiba Masatsugu , Kohata Yukie , Yamagami Hirokazu , Tanigawa Tetsuya , Watanabe Kenji , Watanabe Toshio , Tominaga Kazunari , Arakawa Tetsuo 
Published: May 2010

AbstractObjective:  Gastroesophageal reflux disease (GERD), functional dyspepsia (FD), and irritable bowel syndrome (IBS) are common, and have negative impacts on health‐related quality of life (HR‐QOL). Several studies demonstrated a significant overlap between two of these three diseases. The purpose of this study was to examine the prevalence of GERD, FD, and IBS, their overlap rates, and HR‐QOL for each disease and each overlap compared with healthy controls in the Japanese general population.Methods:  We performed a cross‐sectional study of Japanese workers who visited a clinic for a routine health check‐up, and asked them to fill out a self‐report questionnaire. Prevalence and overlap rate of GERD defined as heartburn and/or acid regurgitation at least weekly, FD and IBS based on Rome III criteria, and HR‐QOL by SF‐8 were examined.Results:  Of the 2680 eligible subjects, 207 (7.7%) were diagnosed as having GERD, 269 (10.0%) as FD, and 381 (14.2%) as IBS. Overlaps were found in 46.9% in GERD, 47.6% in FD, and 34.4% in IBS. Prevalence of overlaps in subjects with IBS was significantly lower compared with those among GERD or FD. Sufferers from GERD, FD, or IBS reported significantly poorer HR‐QOL across all domains compared with controls. Overlaps significantly worsened HR‐QOL in most domains except in the ‘role emotional’ domain. HR‐QOL was particularly poor in the physical component summary for overlapping GERD and in the mental component summary for overlapping IBS.Conclusion:  Overlaps among GERD, FD and IBS were common and worsened HR‐QOL in Japanese general population.
Efficacy of Intracervicovaginal Misoprostol in Second‐Trimester Pregnancy Termination: A Comparison between Live and Dead Fetuses
Authors: Srisomboon Jatupol , Pongpisuttinun Sureeratana 
Published: May 2010

AbstractObjective: To study the complications and compare the success rate and abortion time between the live and the dead fetuses in second‐trimester pregnancy termination with intracervicovaginal misoprostol.Design: A prospective comparative study.Subjects and methods: A total of 89 pregnant women between 14 and 28 weeks of gestation with obstetric, medical, or genetic reasons for termination of pregnancy were recruited to receive 200 μg misoprostol inserted intracervicovagi‐nally every 12 hours.Results: The rates of successful abortions within 12, 24 and 48 hours in live fetuses were 15.1%, 54.7% and 92.5%, respectively, while in dead fetuses were 50.0%, 83.3% and 97.2%, respectively. The success rates within 12 and 24 hours in live‐fetus group were significantly lower than those of the dead‐fetus group (p = 0.0009 and p = 0.01, respectively). The mean abortion time of the live‐fetus group (27.1 hours) was significantly more than that of the dead‐fetus group (15 hours, p = 0.001). No serious complications occurred in terms of hemorrhage, febrile morbidity diarrhea, nausea and vomitingConclusion: Intracervicovaginal misoprostol is an effective and safe method for second‐trimester pregnancy termination. The success rate is higher and the abortion time is less in dead‐fetus pregnancy than those in the live‐fetus pregnancy.
A Case of a Malignant Mixed Tumor in the Vagina
Authors: Takehara Masaki , Hayakawa Osamu , Itoh Eiki , Sagae Satoru , Suzuki Takahiro , Kudo Ryuichi 
Published: May 2010

AbstractMalignant mixed tumors in the vagina are extremely rare. We experienced a case of a malignant mixed tumor (synovioid variant). Surgical treatment was performed, followed by 3 courses of chemotherapy. Up to the present time, 4 years after the first treatment, no signs of recurrence have been observed.
A Case of Concurrent Uterine Cervical Adenocarcinoma and Renal‐Cell Carcinoma, and Subsequent Vaginal Metastasis from the Renal‐Cell Carcinoma
Authors: Yokoyama Yoshihito , Sato Shigemi , Kawaguchi Toshiaki , Saito Yoshiharu 
Published: May 2010

AbstractWe report a case of concurrent uterine cervical adenocarcinoma and renal‐cell carcinoma and a subsequent vaginal metastasis from the renal‐cell carcinoma. The renal‐cell carcinoma, which was located in the upper pole of the right kidney, was detected incidentally by preoperative CT scanning. We simultaneously performed in a timely manner radical hysterectomy, pelvic and paraaortic lymphadenectomies, and a right nephrectomy. Subsequently, however, the patient suffered from vaginal metastasis arising from the renal‐cell carcinoma. As a result of this case, we emphasize the importance of making a thorough preoperative assessment prior to performing any definitive surgery for a gynecologic malignancy.
Ovarian Pregnancy Associated with Microscopic Decidualized Endometriosis of the Ovary: Report of a Case
Authors: Toki Toshihiko , Obinata Miyuki , Nakayama Kuniaki , Oguchi Osamu , Fujii Shingo 
Published: May 2010

AbstractA case of ovarian pregnancy associated with microscopic endometriosis is described. The case satisfied Spiegelberg's four criteria. The associated endometriotic lesion histologically showed prominent decidual change.
The Relationship between Maternity Blues and Thyroid Dysfunction
Authors: Ijuin Tomu , Douchi Tsutomu , Yamamoto Shinichi , Ijuin Yasuhiro , Nagata Yukihiro 
Published: May 2010

AbstractObjective: To investigate whether there is evidence of thyroid dysfunction in women with maternity blues.Methods: Twenty women with maternity blues and 20 age‐matched normal controls were enrolled in our study. The serum levels of 6 kinds of thyroid hormones, cortisol, and prolactin (PRL) of the 2 groups were compared, and obstetric variables were recorded for each subject. In addition, significant variables correlating with the development of maternity blues were determined by stepwise regression analysis.Results: The serum‐free triiodothyronine (FT3) level at 5 days puerperium was lower in the maternity blues group (p < 0.05) than in the control group. In the maternity blues group, the FT3 level at 5 days puerperium was lower than that at 37 weeks of pregnancy and at 1 month puerperium (p < 0.05). The reverse T3 levels and TSH levels at 5 days postpartum were higher in women with maternity blues than among the controls (p < 0.05). The proportion of primiparous women was higher in the maternity blues group (p < 0.01). Stepwise regression analysis revealed that the low FT3 level and primiparity were significantly correlated with the development of maternity blues (R2 = 0.281, p < 0.001).Conclusion: Thyroid dysfunction might be associated with the development of maternity blues.
Vertical Transmission of Hepatitis C Virus: Risk Factors and Infantile Prognosis*
Authors: Xiong Shu Kang , Okajima Yuko , Ishikawa Kazuaki , Watanabe Hiroshi , Inaba Noriyuki 
Published: May 2010

AbstractObjectives: To clarify the incidence and risk factors of the vertical transmission of hepatitis C virus (HCV) and to determine the prognosis of the carrier infants.Methods: At our hospital, 1,941 non‐pathological (non‐HIV carriers) Japanese pregnant women were screened for anti‐HCV antibodies. Sera of the antibody‐positive women were examined by the reverse transcription polymerase chain reaction (RT‐PCR) method, and the positive women and their infants were followed by testing HCV‐related markers.Results: The HCV carrier rate among the pregnant women was 3.5% (68/ 1,941). Four among the 65 infants (6.2%) who were successfully followed for more than 6 months developed the HCV carrier‐state. Of all the risk factors examined, only the elevation (≤ 110 IU/l of maternal serum alanine aminotransferase (ALT) was found to be significant for HCV vertical transmission. Seventy‐five and 50% of the carrier infants manifested chemical hepatitis and seroconverted to an HCV‐RNA‐negative status, respectively, during the follow‐up period.Conclusions: The frequency of HCV vertical transmission was 6.2%. Half of the carrier infants became seronegative for HCV‐RNA. HCV vertical transmission was significantly affected by the maternal serum ALT level prior to delivery.
Seroprevalence of Toxoplasma Antibodies among the Antenatal Population in Bangladesh*
Authors: Dr. Ashrafunnessa  , Khatun Shahla , Islam M. Nazrul , Huq Tahmina 
Published: May 2010

AbstractObjective: To determine the seroprevalence of toxoplasma antibodies (toxoplasma IgG and toxoplasma IgM) among an antenatal population in a hospital of Bangladesh.Methods:Sera from 286 pregnant women were tested for toxoplasma IgG antibody by applying enzyme linked immunosorbent assay (ELISA) technique. Among the 286 sera, 88 sera were randomly selected and tested for toxoplasma IgM applying ELISA.Results:Among 286 patients 110 (38.5%) were positive for toxoplasma IgG antibody and among 88 patients only one (1.1%) was positive for toxoplasma IgM. The seroprevalence gradually increased with age and parity. The seroprevalence of antibody was higher among the women in poor (53.0%) than the upper socio‐economic class (22.0%) and among the women with jobs (55.0%) than the housewife group (35.0%).Conclusion:This study shows that toxoplasmosis is endemic in Bangladesh and also affecting pregnant women. There is need for further detailed studies on toxoplasmosis and its influence on perinatal morbidity and mortality.
Vaginal Birth after Cesarean Delivery: Results in 310 Pregnancies
Authors: Obara Hiromi , Minakami Hisanori , Koike Toshimitsu , Takamizawa Satoru , Matsubar Shigeki , Sato Ikuo 
Published: May 2010

AbstractObjective: To assess and compare the risk associated with a trial of vaginal birth after cesarean section (VBAC) with the risk of an elective repeat cesarean section.Methods:A retrospective review of the records of 310 consecutive women who, at the Jichi Medical School Hospital in the 6‐year period of 1990 through 1995, had previously undergone a primary cesarean section and gave birth to a singleton infant weighing ≥ 2,000 g at ≥ 36 weeks of gestation in a subsequent pregnancy.Results:Elective cesarean sections were performed on 96 (31%) of 310 women, and VBACs were attempted by 214 women (69%). Vaginal deliveries were successful in 132 (43%) of the 310 pregnancies. No maternal deaths or perinatal deaths occurred in either group. A uterine rupture occurred in 2 (0.9%) of the 214 women who attempted a VBAC, and 5 women (2.3%) gave birth to neonates with a 1‐minute Apgar score ≤ 6. None of the 96 women who underwent an elective cesarean section had such complications, although the difference in these complication rates did not reach a significant level.Conclusions: A trial of a VBAC significantly reduced the rate of cesarean sections. Although the rates of uterine rupture and neonatal asphyxia were slightly higher in women who attempted a VBAC than in women who underwent an elective cesarean section, obstetricians should offer the option of a trial of labor, because more than one‐half of the women with a previous cesarean delivery might have successful vaginal deliveries, and the VBAC‐related maternal mortality rate does not reportedly differ between women undergoing a trial of labor and women undergoing an elective repeat cesarean section.
Ovarian Endometrioid Adenocarcinoma Coexistent with Benign and Borderline Endometrioid Adenofibroma: A Case Report
Authors: Ushijima Kimio , Nishida Takashi , Muraoka Yasunori , Sugiyama Torn , Okura Naofumi , Shinagawa Atsuhiko , Imaishi Kiyohisa , Yakushiji Michiaki 
Published: May 2010

AbstractA well‐differentiated endometrioid adenocarcinoma coexistent with benign and borderline‐malignant endometrioid adenofibroma was found in the ovary of a 64‐year‐old woman. She had vaginal bleeding caused by simple hyperplasia of the endo‐metrium due to high levels of sex steroid hormones. A FIGO stage la solid ovarian tumor was identified. It was composed of irregularly shaped endometriotic glands with benign and borderline malignant cytologic features embedded in abundant fibromatous stroma. Well‐differentiated malignant epithelium was adjacent to these areas, but fibromatous stroma was not predominant. She was treated by surgery and three cycles of chemotherapy. This paper describes this unusual tumor and reviews the literature.
Sarcoma Botryoides of the Uterine Cervix: A Case Report
Authors: Qiang Ji Xin , Takahashi Osamu , Hatazawa Junichi , Karube Akihiro , Ohyama Noriaki , Sato Hirokazu , Ota Hirotaka , Sageshima Masato , Tanaka Toshinobu 
Published: May 2010

AbstractRhabdomyosarcoma of the uterine cervix is a very rare disease. We present a case of rhabdomyosarcoma (botryoide type) arising from the introitus of the uterine cervix, and make a discussion on the diagnosis, treatment and involving factors of prognosis.
Spontaneous Rupture of the Uterus Caused by Placenta Percreta at 28 Weeks of Gestation: A Case Report
Authors: Moriya Mitsuhiko , Kusaka Hideto , Shimizu Katsuhiko , Toyoda Nagayasu 
Published: May 2010

AbstractPlacenta percreta is a rare complication of pregnancy. Rupture of the uterus due to placenta percreta is one of the most urgent obstetrical catastrophes. Recently, we observed a patient who developed placenta percreta accompanied by spontaneous uterine rupture at 28 weeks of gestation. A 29‐year‐old gravida 3, para 1, who had a history of one cesarean section and one miscarriage with dilatation and curetage, was seen at 28 weeks of gestation. An acute abdomen and shock were diagnosed. Immediate laparotomy revealed a transverse rupture on the fundus of the uterus. A hysterectomy was performed. Pathological examination of the uterus showed placenta percreta. Rupture of the uterus due to placenta percreta before the onset of labor is extremely rare.
Maternal Sociocultural Status: A Novel Assessment of Risk for the Birth of Small for Gestational Age, Low Birth Weight Infants
Authors: Arif Manzoor A. , Qureshi Aslam H. , Jafarey Sadiqa N. , Alam Syed E. , Arif Khuram 
Published: May 2010

AbstractObjectives: We assessed the significance of maternal sociocultural status within the family as a risk factor for low birth weight‐small for gestational age (LBW‐SGA) births using a novel scoring system and also isolated related medical risk factors.Methods: A prospective matched pairs case control study of 396 LBW‐SGA infants (cases) and 396 term, appropriate for gestational age infants (controls) was set up.Results: Low maternal sociocultural status (p = 0.02) was significantly associated with LBW‐SGA births as were nonregistration for antenatal care (p < 0.001), maternal weight at delivery < 50 kg (p < 0.0001), antepartum hemorrhage/ preeclampsia (p < 0.01), primigravidity and previous small baby (p < 0.001). Other risk factors included birth interval < 24 m (p < 0.001) and poor maternal or paternal education (p < 0.05).Conditional logistic regression identified maternal weight at delivery < 50 kg (OR 4.8, 95% C.I. 3.0–7.6), lack of antenatal care (OR 2.0, 95% C.I. 1.4‐2.9), antepartum hemorrhage/preeclampsia (OR 4.3, 95% C.I. 1.7–10.8) and previous small baby (OR 4.3, 95% C.I. 2.1–8.9) as independent risk factors.Conclusions: Low sociocultural status of the mother within the family is significantly associated with having a LBW‐SGA baby. Further studies are warranted to study this risk factor.
Case Report: A Mixed Tumor of the Vagina
Authors: Kawauchi Shigeto , Fukuda Toshiro , Tsuneyoshi Masazumi 
Published: May 2010

AbstractWe report a case of a mixed tumor arising in the vagina of a 64‐year‐old woman. Microscopically, the tumor was composed of stromal‐type spindle cells and nests of mature squamous cells embedded in myxomatous stroma. We examined the tumor immunohistochemically, ultrastructurally, and cytogenetically. Based on the results, we discuss the histogenesis of this rare tumor.
Use of Transvaginal Color Doppler Ultrasound in the Diagnosis of Ovarian Bleeding: A Report of 10 Cases
Authors: Emoto Makoto , Tamura Riko , Kawarabayashi Tatsuhiko 
Published: May 2010

AbstractTen patients with ovarian bleeding, who were surgically treated, had been preoperatively evaluated using transvaginal color Doppler ultrasound. The blood‐flow velocity waveforms of the bleeding also were analyzed. The bleeding artery of the ovary was clearly detected in 9 of 10 (90%) patients by transvaginal color Doppler ultrasound and was later confirmed by either a laparotomy or laparoscopic surgery. Either a corpus luteum cyst or a ruptured corpus luteum was associated with the bleeding in the 9 of the 10 patients. The resistance‐index value in each bleeding artery examined in the 9 cases was relatively low, ranging from 0.46 to 0.59 (mean: 0.51). Based on our findings, transvaginal color Doppler ultrasound is useful for preoperatively detecting bleeding arteries in clinically severe cases of ovarian bleeding.
Admission Test: A Predictive Test for Fetal Distress in High Risk Labour
Authors: Kulkarni Ashwini Achyut , Shrotri Aparna Nishikant 
Published: May 2010

AbstractObjective: To study predictive utility of admission test (AT) for perinatal outcome in high risk labours.Method: A hundred patients at risk of fetal jeopardy due to uteroplacental insufficiency were screened by admission test. The traces were classified as per the criteria suggested by Ingemarsson and Arulkumaran (1986). The perinatal outcome was correlated with the initial FHR pattern and Chi square test was applied to the results.Results: Fifty‐eight patients had reactive, 35 had equivocal and 7 had ominous tracing. The incidence of operative delivery for fetal distress showed a progressive rise from reactive (5.17%) to ominous (28.5%) pattern group. The perinatal morbidity also showed a rise from 6.89% in the reactive to 31.42% in the equivocal (p < 0.01) and 85.71% in the ominous group (p < 0.02). The reactive pattern was assuring of the fetal well being for next 5 hours. Presence of late decelerations and decelerations of 60 beats or more below the baseline were additional ominous characteristics, associated with a significant increase in perinatal morbidity.Conclusion: Reactive AT appears to be predictive of fetal well being in high risk labours also. Repeat tracing 4 to 5 hours apart may improve the predictive accuracy. Equivocal and ominous patterns require vigilant monitoring.
The Pregnancy Outcome of Acyanotic Heart Disease
Authors: Chig Patrick , Raman Subramaniam , Tham Seng Woh 
Published: May 2010

AbstractObjective: To study the pregnancy outcome of women with acyanotic heart disease.Method: This is a retrospective study from a tertiary referral centre in a developing country over a period of 3 years.Results: There were a total of 19,151 deliveries where 143 cases had heart disease in pregnancy, all of which were acyanotic, giving an incidence of 0.7%. Fifty‐one (38.4%) of these were congenital whereas 82 (61.6%) were acquired. There was no cyanotic heart lesion during this study period. The fetal and maternal outcome of the women with heart disease (study group) was compared with the general obstetric population in the Unit (control group) using the Chi‐squared test. Ninety‐two percent in the study group were asymptomatic (NYHA Class I). The age distribution were no different except in the < 20 years interval where there were significantly fewer in the study group. More women with heart disease were primiparous and fewer were multiparous as compared with the controls. There was no significant difference in the rate of induction of labour (9.8% vs 11.8%). The use of epidural analgesia was significantly higher in the study group (49% vs 13%) as was the instrumental delivery rates (35.7% vs 5.7%) when compared with the controls. The cae‐sarean section rate was no different. The mean gestation of babies born to mothers with heart disease was 38.2 weeks. Significantly fewer babies were in the 3.0–3.5 kg weight interval and more in the 2.5‐3.0 kg interval. However, this did not alter the perinatal mortality rates which was not significantly different (15.3 vs 14.0 per thousand).Conclusion: The fetal and maternal outcome in women with acyanotic heart disease was favourable. It is advocated that the management of these cases should be multidisciplinary to optimise care for these patients.
Effect of Daily Vaginal Disinfection on Duration of Gestation after Premature Rupture of the Membranes and on Infant Outcome
Authors: Watanabe Takashi , Minakami Hisanori , Matsubara Shigeki , Honma Yoko , Uchida Akira , Sato Ikuo 
Published: May 2010

AbstractObjectives: We examined the effects of daily vaginal disinfection on the interval between premature rupture of the membranes (PROM) and delivery and on infant outcome.Methods: Daily vaginal disinfection with povidone iodine was performed on 43 women with PROM. The control group consisted of 59 women with PROM who did not undergo vaginal disinfection. In both groups, the infants born to these women were followed until 1 year of corrected age.Results: The degree of cervical dilatation, the leukocyte count, and the serum C‐reactive protein level on admission did not differ between the 2 groups. Although there was no difference in the gestational week at delivery between the groups, the interval between PROM and delivery was significantly longer in the disinfectant group than among the control subjects (9.5 ±14.9 days vs. 3.9 ±5.1 days, p < 0.01). There was no difference in infant outcome between the 2 groups.Conclusions: These findings suggest that daily vaginal disinfection with povidone iodine prolongs the duration of gestation in women with PROM and dose not have an adverse effect on the fetus.
13‐cis‐Retinoic Acid and Interferon‐α2a Therapy in Locally Advanced Squamous Cell Carcinoma of the Cervix: p53 Alteration, Proliferating Cell Nuclear Antigen Expression and Angiogenesis Response*
Authors: Charuruks Navapun , Voravud Narin , Termrungruanglert Wichai , Lertsanguansinchai Prasert , Tresukosol Damrong , Niruthisard Somchai , Sirisabya Nakorn 
Published: May 2010

AbstractObjective:To evaluate prognostic importance of p53, PCNA and vasculariza‐tion alteration in patients with locally advanced cervical squamous cell carcinoma (SCC) after combination therapy with 13‐cis‐retinoic acid (13cRA) and interferon‐α2a (IFN‐α2a).Methods: 13cRA and IFN‐α2a were administered to patients with locally advanced cervical SCC. Formalin fixed, paraffin embedded tissues sections obtained at pre‐ and post‐therapy, respectively, were stained immunohistochemically with anti‐p53, anti‐PCNA and anti CD31.Results:p53 alteration was demonstrated in 5/10 patients and 3/10 patients pre‐ and post‐therapy, respectively. There was no correlation between p53 alteration and prognosis. After therapy, two patients with complete response had lower PCNA expression whereas the non‐responders demonstrated the opposite result. The vas‐cularization showed a correlation with PCNA and prognosis. In the response group, patients had lower microvessel count while the metastatic group exhibited higher count.Conclusions: The present study suggests that p53 alteration is neither related to the prognosis of cervical SCC nor is it influenced by the combination therapy while PCNA expression and vascularization might be constitute potential markers for tumorigenesis, prognosis and responsiveness to this novel regimen.