bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of diffusion tensor imaging and generalized q-sampling imaging for predicting short-term clinical effect of deep brain stimulation in Parkinson’s disease
Authors: Yuzkan Sabahattin , Hasimoglu Ozan , Balsak Serdar , Mutlu Samet , Karagulle Mehmet , Kose Fadime , Altinkaya Ayca , Tugcu Bekir , Kocak Burak 
Published: May 2024

Abstract

Purpose
To assess whether diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI) metrics could preoperatively predict the clinical outcome of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD).

Methods
In this single-center retrospective study, from September 2021 to March 2023, preoperative DTI and GQI examinations of 44 patients who underwent DBS surgery, were analyzed. To evaluate motor functions, the Unified Parkinson’s Disease Rating Scale (UPDRS) during on- and off-medication and Parkinson’s Disease Questionnaire-39 (PDQ-39) scales were used before and three months after DBS surgery. The study population was divided into two groups according to the improvement rate of scales: ≥ 50% and < 50%. Five target regions, reported to be affected in PD, were investigated. The parameters having statistically significant difference were subjected to a receiver operating characteristic (ROC) analysis.

Results
Quantitative anisotropy (qa) values from globus pallidus externus, globus pallidus internus (qa_Gpi), and substantia nigra exhibited significant distributional difference between groups in terms of the improvement rate of UPDRS-3 scale during on-medication (p = 0.003, p = 0.0003, and p = 0.0008, respectively). In ROC analysis, the best parameter in predicting DBS response included qa_Gpi with a cut-off value of 0.01370 achieved an area under the ROC curve, accuracy, sensitivity, and specificity of 0.810, 73%, 62.5%, and 85%, respectively. Optimal cut-off values of ≥ 0.01864 and ≤ 0.01162 yielded a sensitivity and specificity of 100%, respectively.

Conclusion
The imaging parameters acquired from GQI, particularly qa_Gpi, may have the ability to non-invasively predict the clinical outcome of DBS surgery.
Digital manufacturing techniques and the in vitro biocompatibility of acrylic-based occlusal device materials
Authors: Haugli Ketil Hegerstrøm , Alkarra Dimitri , Samuelsen Jan T. 
Published: May 2024

Abstract
Objectives
Material chemistry and workflow variables associated with the fabrication of dental devices may affect the biocompatibility of the dental devices. The purpose of this study was to compare digital and conventional workflow procedures in the manufacturing of acrylic-based occlusal devices by assessing the cytotoxic potential of leakage products.

Methods
Specimens were manufactured by 3D printing (stereolithography and digital light processing), milling, and autopolymerization. Print specimens were also subjected to different post-curing methods. To assess biocompatibility, a human tongue epithelial cell line was exposed to material-based extracts. Cell viability was measured by MTT assay while Western blot assessed the expression level of selected cytoprotective proteins.

Results
Extracts from the Splint 2.0 material printed with DLP technology and post-cured with the Asiga Flash showed the clearest loss of cell viability. The milled and autopolymerized materials also showed a significant reduction in cell viability. However, by storing the autopolymerized material in dH2O for 12 h, no significant viability loss was observed. Increased levels of cytoprotective proteins were seen in cells exposed to extracts from the print materials and the autopolymerized material. Similarly to the effect on viability loss, storing the autopolymerized material in dH2O for 12 h reduced this effect.

Conclusions/Clinical relevance
Based on the biocompatibility assessments, clinical outcomes of acrylic-based occlusal device materials may be affected by the choice of manufacturing technique and workflow procedures.
Influence of an allogenic collagen scaffold on implant sites with thin supracrestal tissue height: a randomized clinical trial
Authors: Solderer A , Hicklin SP , Aßenmacher M , Ender A , Schmidlin PR 
Published: May 2024

Abstract
Objectives
This randomized clinical trial focused on patients with thin peri-implant soft-tissue height (STH) (≤ 2.5 mm) and investigated the impact of an allogenic collagen scaffold (aCS) on supracrestal tissue height and marginal bone loss (MBL).

Material & methods
Forty patients received bone level implants and were randomly assigned to the test group with simultaneous tissue thickening with aCS or the control group. After three months, prosthetic restoration occurred. STH measurements were taken at baseline (T0) and reopening surgery (TR), with MBL assessed at 12 months (T1). Descriptive statistics were calculated for continuous variables, and counts for categorical variables (significance level, p = 0.05).

Results
At T1, 37 patients were available. At T0, control and test groups had mean STH values of 2.3 ± 0.3 mm and 2.1 ± 0.4 mm. TR revealed mean STH values of 2.3 ± 0.2 mm (control) and 2.6 ± 0.7 mm (test), with a significant tissue thickening of 0.5 ± 0.6 mm in the test group (p < 0.03). At T1, control and test groups showed MBL mean values of 1.1 ± 0.8 mm and 1.0 ± 0.6 mm, with a moderate but significant correlation with STH thickening (-0.34), implant position (0.43), history of periodontitis (0.39), and smoking status (0.27).

Conclusion
The use of an aCS protocol resulted in soft tissue thickening but did not reach a threshold to reliably reduce MBL compared to the control group within the study’s limitations.

Clinical relevance
Peri-implant STH is crucial for maintaining peri-implant marginal bone stability. Marginal bone stability represents a crucial factor in prevention of peri-implantitis development.
German register of clinical trial registration number DRKS00033290.
In “Tone” with dogs: exploring canine musicality
Authors: Pinelli Claudia , Scandurra Anna , Giacoma Cristina , Di Lucrezia Alfredo , D’Aniello Biagio 
Published: May 2024

Abstract
This study investigates the musical perception skills of dogs through playback experiments. Dogs were trained to distinguish between two different target locations based on a sequence of four ascending or descending notes. A total of 16 dogs of different breeds, age, and sex, but all of them with at least basic training, were recruited for the study. Dogs received training from their respective owners in a suitable environment within their familiar home settings. The training sequence consisted of notes [Do-Mi-Sol#-Do (C7-E7-G7#-C8; Hz frequency: 2093, 2639, 3322, 4186)] digitally generated as pure sinusoidal tones. The training protocol comprised 3 sequential training levels, with each level consisting of 4 sessions with a minimum of 10 trials per session. In the test phase, the sequence was transposed to evaluate whether dogs used relative pitch when identifying the sequences. A correct response by the dog was recorded as 1, while an incorrect response, occurring when the dog chose the opposite zone of the bowl, was marked as 0. Statistical analyses were performed using a binomial test. Among 16 dogs, only two consistently performed above the chance level, demonstrating the ability to recognize relative pitch, even with transposed sequences. This study suggests that dogs may have the ability to attend to relative pitch, a critical aspect of human musicality.
Looking backwards to move forwards: insights for climate change adaptation from historical Māori relocation due to natural hazards in Aotearoa New Zealand
Authors: Bailey-Winiata Akuhata P. , Gallop Shari L. , White Iain , Wotherspoon Liam , Fa’aui Tūmanako , Dickson Mark , Ellis Joanne 
Published: May 2024

AbstractClimate change relocation of Indigenous communities is increasing globally. For Māori (the Indigenous peoples of Aotearoa New Zealand), many pā (complexes of significant structures) are at risk to climate change impacts with relocation as one potential adaptation option. For Indigenous peoples, this step is not taken lightly, as connection to place is imperative. The aim of this research is to highlight some histories of Māori communities relocating in response to natural hazards, providing insights from the past to help plan for future adaptation. To do this, we undertook a national-scale textual analysis and identified 51 examples of pā relocating in response to natural hazards since pre-1840. We then focused on a case study with members of two iwi (tribes), who relocated following the 1886 eruption of Mount Tarawera to identify enablers and barriers to relocation, and to draw insights to assist with Māori-led responses to climate change adaptation. We found that key enablers of relocation included whānau (family)-level decision-making, cultural norms of awhi (support), whanaungatanga (relationships), whakapapa (genealogical connection), koha (donation), tuku whenua (gifts of land), and mātauranga Māori (Māori knowledge). In summary, Māori and other Indigenous peoples have rich histories of relocations, utilising their own Indigenous knowledge, local implementation, and adaptability to natural hazards that can be implemented in our modern context.
Intercontinental invasion dynamics of Cercopagis pengoi, an IUCN-listed planktonic invasive species
Authors: Macêdo Rafael L. , Klippel Gabriel , Silva Daniel P. , Haubrock Phillip J. , Vilela Bruno , Mammola Stefano , Rocha Odete , Franco Ana Clara S. 
Published: May 2024

AbstractPredicting the spread of invasive species and understanding the role of niche dynamics in niche transferability are critical challenges in the management of biological invasions, both theoretically and practically. We used complementary species distribution modelling approaches, such as multivariate niche analysis and reciprocal distribution models, to test the niche conservatism hypothesis and to predict the potential distribution of the fishhook waterflea, Cercopagis pengoi. Our analysis indicated a significant similarity between its native and invasive ranges, suggesting that a subset of the Ponto-Caspian propagules may have been the founders of European populations. However, our results contradict the niche conservatism hypothesis, showing that C. pengoi has not fully occupied the available niche within its current invasive ranges. Moreover, we observed a notable niche expansion, reflecting a significant shift in niche following its intercontinental introduction in North America. Given the suitability of new environments for the expansion of C. pengoi and its tendency to evade detection prior to population surges, we recommend a focus on early detection through monitoring of both water columns and bottom sediments. This should be complemented by strict enforcement of ballast water regulations to curtail its spread in North America, Europe, and other suitable non-native regions globally.
Markov switching stereotype logit models for longitudinal ordinal data affected by unobserved heterogeneity in responding behavior
Authors: Colombi Roberto , Giordano Sabrina 
Published: May 2024

AbstractWhen asked to assess their opinion about attitudes or perceptions on Likert-scale, respondents often endorse the midpoint or extremes of the scale and agree or disagree regardless of the content. These responding behaviors are known in the psychometric literature as middle, extremes, aquiescence and disacquiescence response styles that generally introduce bias in the results. One of the key motivations behind our approach is to account for these attitudes and how they evolve over time. The novelty of our proposal, in the context of longitudinal ordered categorical data, is in considering simultaneously the temporal dynamics of the responses (observable ordinal variables) and unobservable answering behaviors, possibly influenced by response styles, through a Markov switching logit model with two latent components. One component accommodates serial dependence and respondent’s unobserved heterogeneity, the other component determines the responding attitude (due to response styles or not). The dependence of the responses on covariates is modelled by a stereotype logit model with parameters varying according to the two latent components. The stereotype logit model is adopted because it is a flexible extension of the proportional odds logit model that retains the advantage of using a single parameter to describe a regressor effect. In the paper, a new interpretation of the parameters of the stereotype model is given by defining the allocation sets as intervals of values of the linear predictor that identify the most probable response. Unobserved heterogeneity, serial dependence and tendency to response style are modelled through our approach on longitudinal data, collected by the Bank of Italy.
CD3, CD8, IFN-γ, tumor and stroma inflammatory cells as prognostic indicators for surgically resected SCLC: evidences from a 10-year retrospective study and immunohistochemical analysis
Authors: Fu Meng , Feng Chunmei , Wang Jialiang , Guo Chang , Wang Yongguang , Gao Rong , Wang Jiexiao , Zhu Qizhi , Zhang Xiaopeng , Qi Jian , Zhang Yani , Bian Yuting , Wang Zhipeng , Fang Yuan , Cao Lejie , Hong Bo , Wang Hongzhi 
Published: May 2024

AbstractCurrent clinical guidelines limit surgical intervention to patients with cT1-2N0M0 small cell lung cancer (SCLC). Our objective was to reassess the role of surgery in SCLC management, and explore novel prognostic indicators for surgically resected SCLC. We reviewed all patients diagnosed with SCLC from January 2011 to April 2021 in our institution. Survival analysis was conducted using the Kaplan–Meier method, and independent prognostic factors were assessed through the Cox proportional hazard model. In addition, immunohistochemistry (IHC) staining was performed to evaluate the predictive value of selected indicators in the prognosis of surgically resected SCLC patients. In the study, 177 SCLC patients undergoing surgical resection were ultimately included. Both univariate and multivariate Cox analysis revealed that incomplete postoperative adjuvant therapy emerged as an independent risk factor for adverse prognosis (p < 0.001, HR 2.96). Survival analysis revealed significantly superior survival among pN0-1 patients compared to pN2 patients (p < 0.0001). No significant difference in postoperative survival was observed between pN1 and pN0 patients (p = 0.062). Patients with postoperative stable disease (SD) exhibited lower levels of tumor inflammatory cells (TIC) (p = 0.0047) and IFN-γ expression in both area and intensity (p < 0.0001 and 0.0091, respectively) compared to those with postoperative progressive disease (PD). Conversely, patients with postoperative SD showed elevated levels of stromal inflammatory cells (SIC) (p = 0.0453) and increased counts of CD3+ and CD8+ cells (p = 0.0262 and 0.0330, respectively). Survival analysis indicated that high levels of SIC, along with low levels of IFN-γ+ cell area within tumor tissue, may correlate positively with improved prognosis in surgically resected SCLC (p = 0.017 and 0.012, respectively). In conclusion, the present study revealed that the patients with pT1-2N1M0 staging were a potential subgroup of SCLC patients who may benefit from surgery. Complete postoperative adjuvant therapy remains an independent factor promoting a better prognosis for SCLC patients undergoing surgical resection. Moreover, CD3, CD8, IFN-γ, TIC, and SIC may serve as potential indicators for predicting the prognosis of surgically resected SCLC.
Validation and Application of a Dried Blood Spot Amoxicillin Assay
Authors: Page-Sharp Madhu , Yoo Okhee , Salman Sam , Davis Timothy M. E. , Moore Brioni R. , Manning Laurens , Batty Kevin T. 
Published: May 2024

AbstractDried blood spot (DBS) antibiotic assays can facilitate pharmacokinetic (PK) investigations in situations where venous blood sampling is logistically and/or ethically challenging. The aim of this study was to establish, validate and demonstrate the application of a DBS amoxicillin assay for PK studies in vulnerable populations. The matrix effect, process efficiency (84–104%) and recovery (85–110%) of the liquid chromatography–mass spectrometry (LC–MS/MS) assay for amoxicillin in DBS was determined at 1, 10 and 100 µg/mL, and three different haematocrits. Thermal stability studies of amoxicillin in DBS were performed and a bridging study comprising 26 paired plasma and DBS samples was conducted in four healthy individuals. The limits of detection and quantification were 0.02 and 0.05 µg/mL for plasma and DBS amoxicillin assays, respectively. Accuracy and interday precision of amoxicillin in DBS (0.1–100 µg/mL) were 88–103% and 4.5–9.2%, respectively. At room temperature (22 °C) and 4 °C, amoxicillin was stable in DBS for ≈4 and 26 h, respectively. There was no degradation of amoxicillin in DBS at −20 °C for > 6 months. When comparing DBS and plasma collected from healthy volunteers, the slope of the Deming regression was 0.74. Amoxicillin CL/F estimates from DBS and plasma concentration data were 40.8 and 30.7 L/h/70 kg, respectively; V/F was 43.2 and 37.4 L/70 kg, respectively. In conclusion, amoxicillin can be reliably assayed from DBS in research studies but may have limited application in therapeutic drug monitoring. Due to poor stability at room temperature, amoxicillin DBS samples should be promptly dried and placed in frozen storage.
The association of resilience and physical activity in older adults: cross-sectional analyses from the NICOLA study
Authors: O’Doherty Maeve , Cunningham Conor , Neill Ruth D. , Tully Mark A. 
Published: May 2024

Abstract
Aim
As more of the world’s population are living longer, supporting the mental and physical health of older adults is becoming increasingly important in public health. Resilience is a dynamic process encompassing positive adaptation in the face of adverse experiences that would otherwise lead to poor outcomes. The aim of the study is to explore the association between physical activity and resilience in older adults.

Subject and methods
The data used in this study was taken from the results of the Self Completed Questionnaires and Computer Assisted Personal Interviews from the Northern Ireland Cohort for the Longitudinal Study of Ageing. A secondary analysis was conducted on a sample of 4040 participants to examine the association between resilience (Brief Resilience Scale) and on moderate/vigorous physical activity (International Physical Activity Questionnaire – Short Form) through chi-square and Mann–Whitney U tests and an ordinal regression being conducted.

Results
Data was included for 4040 participants, of whom 90% did not meet the recommended moderate physical activity guidelines. The findings of this study indicated that higher resilience levels are associated with higher levels of moderate and vigorous physical activity levels.

Conclusion
Worryingly, a large percentage of the older adult population are not sufficiently active and this is something that needs to be addressed. The findings suggest that with these low levels of physical activity, interventions should be created to target this population.
Development and Delphi consensus validation of the Medication-Related Fall screening and scoring tool
Authors: Saeed Dima , Carter Gillian , Miller Ruth , Darcy Carmel , Miller Karen , Madden Kevin , McKee Hilary , Agnew Jayne , Crawford Paula , Parsons Carole 
Published: May 2024

Abstract
Background
Falls are a significant public health problem and constitute a major cause of injuries and mortality. Risk factors for falls are multifactorial and include medication use.

Aim
To develop and investigate the content validity of the Medication-Related fall (MRF) screening and scoring tool.

Method
The MRF tool was developed from clinical practice guidelines addressing medication-related problems, and additional medications identified by specialist pharmacists across a region of the United Kingdom (Northern Ireland). Medication classes were categorised according to their ‘potential to cause falls’ as: high-risk (three points), moderate-risk (two points) or low-risk (one point). The overall medication-related falls risk for the patient was determined by summing the scores for all medications. The MRF was validated using Delphi consensus methodology, whereby three iterative rounds of surveys were conducted using SurveyMonkey®. Twenty-two experts from 10 countries determined their agreement with the falls risk associated with each medication on a 5-point Likert scale. Only medications with at least 75% of respondents agreeing or strongly agreeing were retained in the next round.

Results
Consensus was reached for 19 medications/medication classes to be included in the final version of the MRF tool; ten were classified as high-risk, eight as moderate-risk and one as low-risk.

Conclusion
The MRF tool is simple and has the potential to be integrated into medicines optimisation to reduce falls risk and negative fall-related outcomes. The score from the MRF tool can be used as a clinical parameter to assess the need for medication review and clinical interventions.
Energy-information trade-off induces continuous and discontinuous phase transitions in lateral predictive coding
Authors: Huang Zhen-Ye , Zhou Ruyi , Huang Miao , Zhou Hai-Jun 
Published: May 2024

AbstractLateral predictive coding is a recurrent neural network that creates energy-efficient internal representations by exploiting statistical regularity in sensory inputs. Here, we analytically investigate the trade-off between information robustness and energy in a linear model of lateral predictive coding and numerically minimize a free energy quantity. We observed several phase transitions in the synaptic weight matrix, particularly a continuous transition that breaks reciprocity and permutation symmetry and builds cyclic dominance and a discontinuous transition with the associated sudden emergence of tight balance between excitatory and inhibitory interactions. The optimal network follows an ideal gas law over an extended temperature range and saturates the efficiency upper bound of energy use. These results provide theoretical insights into the emergence and evolution of complex internal models in predictive processing systems.