bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treefrog‐Inspired Flexible Electrode with High Permeability, Stable Adhesion, and Robust Durability
Authors: Lan Tianxiang , Tian Hongmiao , Chen Xiaoliang , Li Xiangming , Wang Chunhui , Wang Duorui , Li Sheng , Liu Gangqiang , Zhu Xinkai , Shao Jinyou 
Published: May 2024

AbstractLong‐term continuous monitoring (LTCM) of physiological electrical signals is an effective means for detecting several cardiovascular diseases. However, the integrated challenges of stable adhesion, low impedance, and robust durability under different skin conditions significantly hinder the application of flexible electrodes in LTCM. This paper proposes a structured electrode inspired by the treefrog web, comprising dispersed pillars at the bottom and asymmetric cone holes at the top. Attachment structures with a dispersed pillar improve the contact stability (adhesion increases 2.79/13.16 times in dry/wet conditions compared to an electrode without structure). Improved permeable duct structure provides high permeability (12 times compared to cotton). Due to high adhesion and permeability, the electrode's durability is 40 times larger than commercial Ag/AgCl electrodes. The treefrog web‐like electrode has great advantages in permeability, adhesion, and durability, resulting in prospects for application in physiological electrical signal detection and a new design idea for LTCM wearable dry electrodes.
Heteroatom(S) (N, S, P) Co‐Doped Reduced Graphene Oxide‐Based Binder‐Free Novel Energy Storage Electrode Material for High Energy Density Supercapacitor
Authors: Ahmad Ikrar , Kumar Anil 
Published: May 2024

AbstractThis manuscript reports a one‐pot synthesis of ternary heteroatoms (N/S/P) co‐doped reduced graphene oxide as an electrode material by simultaneous reduction/doping of/into graphene oxide employing eco‐friendly natural molecule(s) (thiamine monophosphate (TM) and thiamine pyrophosphate (TP)) under mild heating (≤60 °C) and near‐neutral pH (≤8) conditions. It produces N, S, P co‐doped rGO‐TM and N, S, P co‐doped rGO‐TP nanohybrids displaying a well‐connected porous microstructure with significantly doped atomic(%) ‐N (10.0%), S (4.1%), P (0.1%) and N (6.7%), S (2.0%), and P (0.5%), respectively. The symmetric supercapacitor designed using N, S, P‐rGO‐TM‐10 in water‐in‐salt 17 m NaClO4 electrolyte exhibits stable cell voltage of 3.0 V, superb gravimetric energy density (areal energy density) of 47.9 Wh kg−1@522.8 W g−1 (0.2363 Wh cm−2@ 2.5 W cm−2); the excellent cyclic stability (88.8 %) and Coulombic efficiency (99.2%) even after 20 000 cycles. Their energy storage capability is corroborated by the illumination of 109 white LEDs upon lighting a single SSC for 50 s each, driving a motor to run a fan, and forming the tandem device by joining three such cells in series.
A data‐driven topsoil classification framework to support soil health assessment in Minnesota
Authors: Blair Hava K. , Gutknecht Jessica L. , Cates Anna M. , Lewandowski Ann Marcelle , Jelinski Nicolas Adam 
Published: May 2024

AbstractSoil health assessments aim to quantify soil health status using indicators linked to ecosystem services such as yield, nutrient cycling, water cycling, or carbon storage. Many indicators are related to soil biological processes, which can be challenging to interpret because they are sensitive not only to management, but also to nonmanagement variables such as soil inherent properties, topography, and climate. Existing studies address this challenge by grouping similar soils by taxonomy, geography, or a combination of these and other variables for soil health assessment. We investigated whether grouping soils based on multiple quantitative topsoil properties could be an alternative to taxonomic or geographic groups. We used an unsupervised classification algorithm,k‐means, to cluster publicly available soil and climate data for Minnesota. Clustering into eight conceptual groups (“clusters”) based on 10 topsoil properties was determined to be the optimal algorithm output. We evaluated the ability of our soil clusters and other grouping methods to explain variance in eight soil health indicators. We found the combination of Major Land Resource Area (MLRA) and soil cluster performed best, explaining as much or more variance than other groupings for five of the eight indicators. The clusters distinguish zones of topsoil variation at the field scale, and MLRAs account for broader scale variation in climate and other landscape factors. The approach we describe is flexible and could be applied at different locations and scales to produce conceptual soil groups and associated maps to support soil health test sampling and interpretation at the field scale.
Usefulness and drawbacks of comparing balloon‐expandable and self‐expanding TAV
Authors: De Backer Ole , Van Belle Eric 
Published: May 2024

Key points
TAVR procedures performed with new‐generation balloon‐expandable and self‐expanding valves had comparable in‐hospital outcomes in the Brazilian RIBAC‐NT registry.
Center and operator volumes have an impact on TAVR outcomes; this makes a point to opt for highvolume centralized TAVR centres.
The future will tell whether comparative TAVR studies are truly meaningful in an era of a more patient‐tailored TAVR approach and device choice.
Percutaneous axillary extracorporeal membrane oxygenation supported complex left main bifurcation percutaneous coronary intervention
Authors: Rohm Charlene L. , Pasrija Chetan , Raj Leah M. 
Published: May 2024

AbstractA 66‐year‐old man with multiple comorbidities including severe peripheral artery disease and heart failure with reduced ejection fraction presented with complex coronary artery disease with an elevated Society of Thoracic Surgeons Predicted Risk of Mortality for coronary artery bypass grafting and a Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery score of 18. With a multidisciplinary heart team approach, the patient successfully underwent percutaneous axillary venoarterial extracorporeal membrane oxygenation (VA‐ECMO) supported high‐risk percutaneous coronary intervention of a heavily calcified left main bifurcation lesion. Given the patient's peripheral artery disease, alternative arterial access for ECMO cannulation was performed percutaneously via the right axillary artery. Additionally, adequate coronary calcium modification was critical to successful stenting of a heavily calcified left main bifurcation. This case highlights a novel approach to obtaining alternative arterial access for ECMO cannulation and emphasizes the importance of calcium modification to achieve excellent stent results.
Hospital readmission prediction with hybrid‐sampling and self‐paced balance learning
Authors: Xu Ying , Zhang Ning , Wang Ao , Feng Tao , Du Guodong 
Published: May 2024

SummaryHospital readmission prediction is defined as an evaluation task to model the historical medical data to predict whether patients will be readmitted after discharge. In the past few years, many feasible and effective prediction methods have been proposed, however, most of them neglect the imbalanced distribution of medical data, which causes great difficulties in modeling. Thus, we proposed a new hospital readmission prediction method, which utilizes hybrid‐sampling and self‐paced balance learning strategies to solve the class‐imbalance problem. To be specifically, we first employ an interference negative sample deletion strategy to reduce the probability of important majority class samples being deleted. Then, we design a hard positive sample generation strategy to generate more positive samples. Meanwhile, we also introduce a self‐paced balance factor during the oversampling process to improve the similarity between newly generated minority class samples and hard positive samples. Finally, we perform the experiments on six real‐world readmission datasets to indicate the superiority of the proposed method.
Family structure and material hardship: Child and adolescent pathways to health and well‐being
Authors: Miller Ashley , Johnston Carol A. 
Published: May 2024

AbstractChildren's early experiences have potential to shape their development through early childhood, middle childhood, and into adolescence. Family structure at birth and material hardship may offer insight into how children's health and well‐being are shaped within their family of origin. The current paper examined (a) the association between family structure at birth and material hardship 1‐year post‐birth and (b) the differential impact of race on the associations between family structure and material hardship. We further explored the association between family structure and material hardship on self‐reported health in (a) middle childhood and (b) adolescence. Using the Future of Families and Child Wellbeing dataset, an ordinary least squares (OLS) regressions and structural equation path models (SEM) were used to examine associations between family structure, material hardship, and health outcomes (body mass index [BMI], anxiety, and suicidal ideation). Results indicated that family structure predicted material hardship at 1‐year until maternal characteristics were taken into account. Race/ethnicity did not moderate the association. Also, family structure at birth was indirectly associated with youth anxiety through material hardship but did not account for BMI or sucidical ideation. Social supports and state policies should prioritize maternal health access and ensure families are able to meet their basic needs to mitigate children's health risks.
Ambulatory care hematology/oncology pharmacy services: A comprehensive review by the Saudi Oncology Pharmacy Assembly
Authors: Alsuhebany Nada , Alkhudair Nora , Alzahrani Mohammed , Alnajjar Fouad , Alrajhi Abdullah M. , Aldoughaim Maha , Alnuhait Mohammed , Alharbi Atika , Alshamrani Majed , Alshaya Omar 
Published: May 2024

AbstractSaudi Vision 2030 has driven significant changes in ambulatory care pharmacy services in the Kingdom of Saudi Arabia (KSA), transitioning pharmaceutical care from inpatient to outpatient settings. With a growing need to address non‐communicable diseases, particularly cancer, ambulatory care oncology pharmacy services are of paramount importance. This study aims to evaluate the potential benefits and challenges of establishing such services in the KSA and offers recommendations for clinical pharmacists. A comprehensive literature search was conducted using PubMed, MEDLINE, EMBASE, and Google Scholar, encompassing research from inception to September 2023. The search focused on English language studies related to ambulatory care oncology/hematology pharmacy services. Among the 1351 studies found, those assessing the impact of clinical pharmacists on patient outcomes in outpatient oncology clinics were included. The review of the literature highlights the substantial impact of clinical pharmacists in outpatient hematology/oncology settings. A selection of several studies revealed their role in improving patient care, reducing health care costs, and enhancing treatment outcomes. Notable findings include a high acceptance rate of pharmacist interventions with significant cost savings, increased pharmacist involvement in patient encounters, and reduced emergency department visits and inpatient admissions due to pharmacist interventions. These results showed the valuable contributions of clinical pharmacists in the international outpatient oncology setting. Establishing ambulatory care hematology/oncology pharmacy services in Saudi Arabia is critical, considering the rising cancer burden. The value of specialized oncology clinical pharmacists in the outpatient setting is emphasized by various studies conducted in the United States. This review proposes a framework for patient‐centered oncology practices, serving as a valuable resource for the strategic development of ambulatory care oncology pharmacy services in Saudi Arabia. These efforts align with Saudi Vision 2030's broader goals of enhancing health care quality and patient care.
Pharmacist administered parenteral medications: A descriptive report of an inpatient training program
Authors: Dillon Ryan C. , Leffler Carmen , Schell Ryan F. , Sherlin Kristen C. , Fleenor L. Montana , McLaughlin Linda B. 
Published: May 2024

AbstractIntroductionParenteral medication administration is a crucial aspect of in‐hospital patient care and has been historically managed by nurses and physicians. Despite pharmacists' extensive training in the medication use process, their underutilization in medication administration stems from various factors, including the lack of formalized training, limited awareness by other healthcare professionals, and unclear legal guidance. This report discusses the implementation and outcomes of a pharmacist medication administration program at a large academic medical center.MethodsThe initiative began by revising hospital policies, enabling pharmacists to administer medications during emergencies. Documentation and communication protocols were established. Training included an online module and hands‐on sessions covering various topics with a focus on parenteral medication administration and medication safety. Following completion of the program, competency of pharmacists was assessed by pharmacists experienced in intravenous administration using simulated patient case scenarios. Following implementation, the frequency and characteristics of pharmacist administered medications were captured and described.ResultsThirty pharmacists, including 11 residents, participated. Seven pharmacists administered 349 doses of medications to 284 patients in emergency situations. Administrations by pharmacists included 227 titratable infusions, 72 intermittent or continuous infusions, 49 intravenous pushes, and 1 intranasal naloxone. Classes of medications included high risk products such as vasopressors, sedatives, antiarrhythmics, and thrombolytics. No extravasations or infiltrations were reported.ConclusionImplementation of the pharmacist medication administration program signifies significant progress in strengthening the pharmacists' role in patient care at the bedside specifically highlighting the competency of pharmacists to administer parenteral products during emergency situations. The absence of adverse events highlights the feasibility and safety of integrating pharmacists into the bedside team. As the landscape of health‐system pharmacy evolves, embracing standardized training programs like ours reemphasize pharmacists' essential contributions to the multidisciplinary healthcare teams, ultimately enhancing patient care and safety.
Evaluation of an initiative to address polypharmacy in hospitalized older adults
Authors: Meaney Calvin J. , Tjota Natalie , Pham Kevin , Prescott Gina , Doloresco Fred , Ott Michael , Wahler Robert , Wikerd Zachary 
Published: May 2024

AbstractBackgroundPolypharmacy contributes to medication‐related harm in older adults. Deprescribing interventions are often employed in the outpatient setting, potentially missing patients with limited healthcare access. Hospitalization represents a unique touch point to address polypharmacy in older adults with a multidisciplinary team.MethodsThis retrospective cohort study examined the feasibility and effectiveness of a polypharmacy intervention in hospitalized older adults. The intervention was developed by a multidisciplinary team with a quality improvement framework and implemented by clinical pharmacists on an academic teaching service. Adults aged 65 years and older were included. Pharmacists completed a comprehensive medication review with the identification of medication therapy problems (MTPs), with additional evaluation for polypharmacy (five or more chronic medications) and potentially inappropriate medications (PIMs) using validated tools (Beers and STOPP/START criteria), with recommendations implemented during hospitalization. Descriptive statistics were used to describe the intervention and its outcomes. Reporting followed the SQUIRE statement.ResultsThe polypharmacy intervention was provided to 155 patients. Polypharmacy occurred in 98.7% of older adults, whereas 82.6% received at least one PIM (261 total). This demonstrates a significant need for an intervention to address polypharmacy and PIMs during hospitalization. A median of two MTPs was identified per patient (total 287), the most common being adverse drug reaction (present in 52.3% of patients), medication without indication (47.7%), and indication without medication (31%). Opioids were the most common PIM (present in 36.1% of patients), followed by benzodiazepines (10.3%) and skeletal muscle relaxants (8.4%). A total of 40.6% of PIMs were successfully deprescribed at discharge.ConclusionPolypharmacy is ubiquitous in hospitalized older adults. A multidisciplinary approach to deprescribing can reduce PIMs during hospitalization.
Detection of early metaphyseal changes in a piglet model of Legg‐Calvé‐Perthes disease using quantitative mapping of MRI relaxation times
Authors: Buko Erick O. , Armstrong Alexandra R. , Laine Jennifer C. , Tóth Ferenc , Johnson Casey P. 
Published: May 2024

AbstractLegg‐Calvé‐Perthes disease (LCPD) is a childhood hip disorder characterized by ischemic injury to the epiphysis of the femoral head, but changes to the metaphysis have also been implicated in its pathogenesis. Quantitative magnetic resonance imaging (MRI) relaxation time mapping techniques are potentially useful to detect injury in LCPD, but studies to date have focused on the epiphysis. The purpose of this study was to assess whether T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation times can detect early metaphyseal changes in an LCPD piglet model. Complete epiphyseal ischemia of one femoral head was surgically induced and confirmed using contrast‐enhanced MRI in n = 10 6‐week‐old piglets; the contralateral side was unoperated. The bilateral hips were imaged 1 week after surgery in vivo at 3T MRI using relaxation time mapping and contrast‐enhanced MRI. Relaxation times and thicknesses of the metaphyseal primary and secondary spongiosa were measured and compared between the ischemic and contralateral‐control femoral heads using paired t‐tests. In the ischemic femoral heads, T2 relaxation times were significantly increased in the primary spongiosa (6.7 ± 9.8 ms, p = 0.029), and T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation times were significantly decreased in the secondary spongiosa (respectively: −13.3 ± 9.3 ms, p = 0.013; −32 ± 23 ms, p < 0.001; −43 ± 41 ms, p = 0.009; and −39 ± 13 ms, p < 0.001). The secondary spongiosa thickness was also significantly decreased in the ischemic femoral heads (p < 0.001). In conclusion, T2, T1ρ, adiabatic T1ρ, and adiabatic T2ρ relaxation time mapping techniques can detect early changes in the metaphysis following ischemic injury to the epiphysis of the femoral head in a piglet model of LCPD.
Age‐dependent decline of B3AR agonist‐mediated activation of FAP UCP‐1 expression in murine models of chronic rotator cuff repair
Authors: Diaz Agustin , Sang Luke , Garcia Steven , Wague Aboubacar , Davies Michael , Youn Alex , Liu Xuhui , Feeley Brian T. 
Published: May 2024

AbstractAmibegron, a β3‐adrenergic receptor (B3AR) agonist, has recently been shown to provide therapeutic effects for chronic rotator cuff (RC) tears by inducing the expression of uncoupling protein 1 (UCP‐1), a marker of brown fat, in fibroadipogenic progenitors (FAPs). However, it remains to be seen if these beneficial effects hold true with age and in older, more clinically relevant populations. This study seeks to understand the impacts of aging on the efficacy of amibegron to treat chronic RC tears. Young (4‐month‐old) and aged (33‐month‐old) C57BL/6 mice underwent a RC injury procedure with delayed repair (DR). Mice were equally randomized to receive amibegron or dimethyl sulfoxide (DMSO) treatments after repair. Functional ability was measured at baseline and 6‐weeks after DR. Wet muscle weight and histology of injured and contralateral supraspinatus were also analyzed 6‐weeks post‐DR. For in vitro histology and real‐time quantitative PCR experiments, FAPs were isolated from young and aged mice via fluorescence‐activated cell sorting. Young and aged FAPs were treated with amibegron or DMSO either immediately after seeding (early exposure) or 8‐days after seeding (late exposure). In vitro results showed that amibegron‐mediated FAP UCP‐1 expression decreases with age. In vivo data demonstrated that aged mice have a decreased responsiveness to amibegron and decreased propensity for intramuscular FAP UCP‐1 expression. Further, delayed amibegron treatment with RC repair did not lead to improvements in muscle atrophy and functional outcomes. Our findings demonstrate that age and the timing of interventions play a critical role in FAP‐targeted therapeutics for chronic injuries.
Development and evaluation of a deep learning framework for the diagnosis of malnutrition using a 3D facial points cloud: A cross‐sectional study
Authors: Wang Xue , Liu Yan , Rong Zhiqin , Wang Weijia , Han Meifen , Chen Moxi , Fu Jin , Chong Yuming , Long Xiao , Tang Yong , Chen Wei 
Published: May 2024

AbstractBackgroundThe feasibility of diagnosing malnutrition using facial features has been validated. A tool to integrate all facial features associated with malnutrition for disease screening is still demanded. This work aims to develop and evaluate a deep learning (DL) framework to accurately determine malnutrition based on a 3D facial points cloud.MethodsA group of 482 patients were studied in this perspective work. The 3D facial data were obtained using a 3D camera and represented as a 3D facial points cloud. A DL model, PointNet++, was trained and evaluated using the points cloud as inputs and classified the malnutrition states. The performance was evaluated with the area under the receiver operating characteristic curve, accuracy, specificity, sensitivity, and F1 score.ResultsAmong the 482 patients, 150 patients (31.1%) were diagnosed as having moderate malnutrition and 54 patients (11.2%) as having severe malnutrition. The DL model achieved the performance with an area under the receiver operating characteristic curve of 0.7240 ± 0.0416.ConclusionThe DL model achieved encouraging performance in accurately classifying nutrition states based on a points cloud of 3D facial information of patients with malnutrition.
There is high variability in quantitative measurement techniques in glenohumeral capsular measurements for shoulder instability: A systematic review
Authors: Tisherman Robert T. , Bulleit Clark , Champagne Allen A. , Fatora Gabrielle C. , Lau Brian C. 
Published: May 2024

AbstractPurposeInstability of the glenohumeral joint remains a complex clinical issue with high rates of surgical failure and significant morbidity. Advances in specific radiologic measurements involving the glenoid and the humerus have provided insight into glenohumeral pathology, which can be corrected surgically towards improving patient outcomes. The contributions of capsular pathology to ongoing instability remain unclear. The purpose of this study is to provide a systematic review of existing glenohumeral capsular measurement techniques published in the last 15 years.MethodsA systematic review of multiple databases was performed following PRISMA guidelines for all primary research articles between 2008 and 2023 with quantitative measurements of the glenohumeral capsule in patients with instability, including anterior, posterior and multi‐directional instability.ResultsThere were a total of 14 articles meeting the inclusion criteria. High variability in measurement methodology across studies was observed, including variable amounts of intra‐articular contrast, heterogeneity among magnetic resonance sequence acquisitions, differences in measurements performed and the specific approach taken to compute each measurement.ConclusionThere is a need for standardization of methods in the measurement of glenohumeral capsular pathology in the setting of glenohumeral instability to allow for cross‐study analysis.Level of EvidenceLevel III.