bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinematics of regional salt flow in the northern Gulf of Mexico
Authors: Fort Xavier , Brun Jean-Pierre 
Published: February 2012

Abstract
The kinematics of regional-scale salt flow in the northern Gulf of Mexico is analysed using: (i) a map of shelf-break contours at the termination of successive depositional episodes; (ii) the location and geometry of large-scale structures of the slope domain as imaged by seismics; and (iii) digital slope bathymetry. In the north margin, salt has flowed towards the SW since the Cretaceous with three main stages of development prior to, during and after a massive salt extrusion in the Early Miocene time. The corresponding sequence of structural development is discussed using a laboratory model. Contrary to all previous interpretations that invoked sedimentary loading as the main driving force, the analysis of regional-scale salt flow implies that the salt tectonics of the northern Gulf of Mexico is predominantly controlled by gliding above the margin dip. The SW-directed salt flow indicates that the north margin of the northern Gulf of Mexico trends NW–SE, in agreement with plate kinematic models in which the Yucatan continental block has undergone a 45–60° dextral rotation relative to its present orientation.
Basin-scale salt tectonic processes of the Laurentian Basin, Eastern Canada: insights from integrated regional 2D seismic interpretation and 4D physical experiments
Authors: Adam J. , Krezsek C. 
Published: February 2012

Abstract
This study integrates seismic interpretation and 3D analogue experiments monitored by digital image correlation techniques to investigate the evolution of the salt structures and the related depositional systems in the Laurentian Basin offshore Atlantic Canada. During the late Triassic, a layer of more than 3 km thick salt was deposited locally in a set of interconnected rift half-grabens forming a 50–70 km wide evaporite basin in the northern part of the Scotian Basin salt provinces. High sediment input in the Jurassic and early Cretaceous mobilized the salt into complex salt tectonic features, which suggest four kinematic domains with: (1) salt welds and pillows; (2) extensional diapirs and canopies; (3) contractional diapirs and folds; and (4) allochthonous salt nappe. The landward grabens trapped most of the Early Jurassic sediments by passive downbuilding into the salt with local extension. The expelled salt has been evacuated basinwards into a large contractional salt massif. The rapid advance of the allochthonous nappe was coeval with the Late Jurassic extensional collapse of the inflated salt massif due to seaward sediment progradation. Late Cretaceous and Tertiary progradation over the salt nappe caused extensional deformation with growth faulting and formation of minibasins on the secondary salt detachment level.
Evolution of salt structures during extension and inversion of the Offshore Parentis Basin (Eastern Bay of Biscay)
Authors: Ferrer O. , Jackson M. P. A. , Roca E. , Rubinat M. 
Published: February 2012

Abstract
The Late Jurassic–Cretaceous Parentis Basin (Eastern Bay of Biscay) illustrates a complex geological interplay between crustal tectonics and salt tectonics. Salt structures are mainly near the edges of the basin, where Jurassic–Lower Cretaceous overburden is thinner than in the basin centre and allowed salt anticlines and diapirs to form. Salt diapirs and walls began to rise reactively during the Late Jurassic as the North Atlantic Ocean and the Bay of Biscay opened. Some salt-cored drape folds formed above basement faults from the Upper Jurassic to Albian. During Albian–Late Cretaceous times, passive salt diapirs rose in chains of massive salt walls. Many salt diapirs stopped growing in the Mid-Cretaceous when their source layer depleted. During the Pyrenean orogeny (Late Cretaceous–Cenozoic), the basin was mildly shortened. Salt structures absorbed almost all the shortening and were rejuvenated to form squeezed diapirs, salt glaciers and probably subvertical welds, some of which were later reactivated as reverse faults. No new diapirs formed during the Pyrenean compression, and salt tectonics ended with the close of the Pyrenean orogeny in the Middle Miocene. Using reprocessed industrial seismic surveys, we document how salt tectonics affected the structural evolution of this offshore basin largely unknown to the international audience.
Concepts in halokinetic-sequence deformation and stratigraphy
Authors: Giles Katherine A. , Rowan Mark G. 
Published: February 2012

Abstract
Halokinetic sequences are unconformity-bound packages of thinned and folded strata adjacent to passive diapirs. Hook halokinetic sequences have narrow zones of deformation (50–200 m), >70° angular discordance, common mass-wasting deposits and abrupt facies changes. Wedge halokinetic sequences have broad zones of folding (300–1000 m), low-angle truncation and gradual facies changes. Halokinetic sequences have thicknesses and timescales equivalent to parasequence sets and stack into composite halokinetic sequences (CHS) scale-equivalent to third-order depositional cycles. Hook sequences stack into tabular CHS with sub-parallel boundaries, thin roofs and local deformation. Wedge sequences stack into tapered CHS with folded, convergent boundaries, thicker roofs and broad zones of deformation. The style is determined by the ratio of sediment-accumulation rate to diapir-rise rate: low ratios lead to tabular CHS and high ratios result in tapered CHS. Diapir-rise rate is controlled by the net differential load on deep salt and by shortening or extension. Similar styles of CHS are found in different depositional environments but the depositional response varies. CHS boundaries (unconformities) develop after prolonged periods of slow sediment accumulation and so typically fall within transgressive systems tracts in shelf settings and within highstand systems tracts in deepwater settings. Sub-aerial settings may lead to erosional unroofing of diapirs and consequent upward narrowing of halokinetic deformation zones.
Wedges and buffers: some new structural observations from the Dnieper–Donets Basin, onshore Ukraine
Authors: Brown Jonathan , Bowyer M. , Zolotarenko V. 
Published: February 2012

Abstract
The onshore Ukraine Dnieper–Donets Basin (DDB) is a large partially inverted late Palaeozoic intracratonic basin. Rifting began in the late Devonian when two evaporite sequences were deposited, and Carboniferous post-rift thermal sag was accompanied in some areas by some extension. Although important quantities of Devonian salt are calibrated by wells and diapirs have been documented, classic salt diapirs are probably not as common as suggested by the literature. Indeed, in several parts of the basin salt movement was stopped and buried by up to 5 km of overburden. Four important tectonic events related to salt movement have been documented over the DDB: Tournaisian–Early Visean extension, Middle Serpukhovian extension, Late Carboniferous–Early Permian movements mostly documented recently as extension and uplift and Alpine compression. Seismic imaging of the basin has not traditionally been of the highest quality, but the reprocessed seismic data made available over several parts of the DDB as part of a Ferrexpo/RDS multi-licence project has enabled three new structural observations of the basin to be made. Firstly, it is proposed that basin margin extension, facilitated by listric faulting with thin-skinned décollement on Devonian salt and exemplified by well-imaged Tournaisian syntectonic wedges, is linked to thick-skinned partial inversion of some basement rift faults. Secondly, it is proposed that these thick-skinned faults acted as obstacles or buffers, where monoclines began to develop. These folds were exaggerated by the later tectonic movements. Thirdly, we propose that these linked tectonic events may have been caused by pulses of sag which punctuated the Lower Carboniferous post-rift thermal sag process. These three observations fit neatly with published interpretations of Tournaisian–Lower Visean and Middle Serpukhovian extension. Finally, however, a literature review and new seismic interpretation also clearly show that Late Carboniferous–Early Permian movements inverted marginal listric faults and their Tournaisian wedges, and also inverted the downdip thick-skinned faults causing the monoclines to further develop prior to the Alpine overprint. This, contrary to many published papers over the last 15 years or so, suggests that this Late Carboniferous–Early Permian event brought shortening rather than extension to the DDB.
Numerical modelling of the displacement and deformation of embedded rock bodies during salt tectonics: A case study from the South Oman Salt Basin
Authors: Li Shiyuan , Abe Steffen , Reuning Lars , Becker Stephan , Urai Janos L. , Kukla Peter A. 
Published: February 2012

Abstract
Large rock inclusions are embedded in many salt bodies and these respond to the movements of the salt in a variety of ways including displacement, folding and fracturing. One mode of salt tectonics is downbuilding, whereby the top of a developing diapir remains in the same vertical position while the surrounding overburden sediments subside. We investigate how the differential displacement of the top salt surface caused by downbuilding induces ductile salt flow and the associated deformation of brittle stringers by an iterative procedure to detect and simulate conditions for the onset of localization of deformation in a finite element model, in combination with adaptive remeshing. The model set-up is constrained by observations from the South Oman Salt Basin, where large carbonate bodies encased in salt form substantial hydrocarbon plays. The model shows that, depending on the displacement of the top salt, the stringers can break very soon after the onset of salt tectonics and can deform in different ways. If extension along the inclusion dominates, stringers are broken by tensile fractures and boudinage at relatively shallow depth. Spacing of the boudin–bounding faults can be as close as 3–4 times the thickness of the stringer. In contrast, salt shortening along the inclusion may lead to folding or thrusting of stringers.
Fracture pattern analysis as a tool for constraining the interaction between regional and diapir-related stress fields: Poza de la Sal Diapir (Basque Pyrenees, Spain)
Authors: Quintà A. , Tavani S. , Roca E. 
Published: February 2012

Abstract
During diapir evolution the local stress field results from the interaction between diapir-related and remote ‘regional’ stress fields. The fracture pattern hosted in the overburden can register this evolving interaction, providing significant insights for the unravelling of the diapir kinematics. In this work we present the example of the Poza de la Sal Diapir, which is a salt diapir that pierces the synorogenic deposits of the Basque Pyrenees. The integrated analysis of mesostructural data, which includes field-collected faults, joints and fracture traces digitalized on high-resolution orthophotos, allowed us to establish an evolutionary model for the stress field around diapirs. The presented data support the idea that, during diapir evolution, stress fields evolve from mostly regional-related to mostly diapir-related. Contrasting with other geological data (seismic data, geological map and cross-section), we observe that different methods provide complementary information, coherent with the proposed evolutionary model of the Poza de la Sal Diapir.
Role of halokinesis in controlling structural styles and sediment dispersal in the Santos Basin, offshore Brazil
Authors: Guerra Marta C. M. , Underhill John R. 
Published: February 2012

Abstract
Salt–sediment interplay in the Santos Basin is investigated integrating seismic interpretation, kinematic restoration and analogue modelling. Deformation within the post-salt sequence results from thin-skinned gravitational gliding and spreading, driven primarily by halokinesis, greatly affected by massive sediment inflows. The impressive landward-dipping listric Cabo Frio Fault controls the major depocentres updip, whereas salt-cored folds accommodate downdip shortening. Sediment supply from confluent directions creates a complex interference pattern of superposed folds with intervening polygonal minibasins. A new structure is identified (termed the ‘Ilha Grande Gravitational Cell’), a linked system of updip extension and downdip contraction detached on salt, comprising the Cabo Frio Fault and minibasins. It moves to the SE, with eastern and western borders suggesting lateral gradients of slippage. This thin-skinned feature results from the differential load imposed by a thick prograding wedge over the ductile salt and is independent of pre-salt structures. The post-salt sequence moves basinwards due to halokinesis, thereby changing position relative to the pre-salt sequence, which implies that any present-day correspondence between pre- and post-salt structures may not attest to linkage in the past. Application of kinematic restoration techniques allows the true position and geometry of the key elements through time, improving petroleum systems assessment.
A knowledge mining framework for business analysts
Authors: Palpanas Themis 
Published: February 2012

Several studies have focused on problems related to data mining techniques, including several applications of these techniques in the e-commerce setting. In this work, we describe how data mining technology can be effectively applied in an e-commerce environment, delivering significant benefits to the business analyst. We propose a framework that takes the results of the data mining process as input, and converts these results into actionable knowledge, by enriching them with information that can be readily interpreted by the business analyst. The framework can accommodate various data mining algorithms, and provides a customizable user interface.
We experimentally evaluate the proposed approach by using a real-world case study that demonstrates the added benefit of the proposed method. The same study validates the claim that the produced results represent actionable knowledge that can help the business analyst improve the business performance, since it significantly reduces the time needed for data analysis, which results in substantial financial savings.
The OPCML Tumor Suppressor Functions as a Cell Surface Repressor–Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer
Authors: McKie Arthur B. , Vaughan Sebastian , Zanini Elisa , Okon Imoh S. , Louis Louay , de Sousa Camila , Greene Mark I. , Wang Qiang , Agarwal Roshan , Shaposhnikov Dmitry , Wong Joshua L. C. , Gungor Hatice , Janczar Szymon , El-Bahrawy Mona , Lam Eric W-F. , Chayen Naomi E. , Gabra Hani 
Published: February 2012

Abstract
Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy, and its molecular basis is poorly understood. We previously demonstrated that opioid binding protein cell adhesion molecule (OPCML) was frequently epigenetically inactivated in epithelial ovarian cancers, with tumor suppressor function in vitro and in vivo. Here, we further show the clinical relevance of OPCML and demonstrate that OPCML functions by a novel mechanism in epithelial ovarian cancer cell lines and normal ovarian surface epithelial cells by regulating a specific repertoire of receptor tyrosine kinases: EPHA2, FGFR1, FGFR3, HER2, and HER4. OPCML negatively regulates receptor tyrosine kinases by binding their extracellular domains, altering trafficking via nonclathrin-dependent endocytosis, and promoting their degradation via a polyubiquitination-associated proteasomal mechanism leading to signaling and growth inhibition. Exogenous recombinant OPCML domain 1–3 protein inhibited the cell growth of epithelial ovarian cancers cell in vitro and in vivo in 2 murine ovarian cancer intraperitoneal models that used an identical mechanism. These findings demonstrate a novel mechanism of OPCML-mediated tumor suppression and provide a proof-of-concept for recombinant OPCML protein therapy in epithelial ovarian cancers.
Significance: The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain and altering trafficking to a nonclathrin, caveolin-1–associated endosomal pathway that results in receptor tyrosine kinase polyubiquitination and proteasomal degradation. Recombinant OPCML domain 1–3 recapitulates this mechanism and may allow for the implementation of an extracellular tumor-suppressor replacement strategy. Cancer Discovery; 2(2); 156–71. © 2012 AACR.
Read the Commentary on this article by Wu and Sood, p. 115.
This article is highlighted in the In This Issue feature, p. 95.
Cancers of the Colon and Rectum: Identical or Fraternal Twins?
Authors: Hong Theodore S. , Clark Jeffrey W. , Haigis Kevin M. 
Published: February 2012

Abstract
Colorectal cancer represents a major cause of cancer morbidity and mortality, with approximately 1.2 million cases and 600,000 deaths worldwide each year. Because of the anatomic continuity of the colon into the rectum, cancers affecting these organs have historically been considered equivalent. In this Prospective, we discuss the clinical and experimental data suggesting that colon cancer and rectal cancer are highly related, but distinct, diseases. Reconsidering the relationship between these cancers has implications for the development of new therapeutic paradigms. Cancer Discovery; 2(2); 117–21. ©2012 AACR.
RETRACTED: Polymorphisms in the 5-HTTLPR Gene Mediate Storage Capacity of Visual Working Memory
Authors: Anderson David E. , Bell Theodore A. , Awh Edward 
Published: February 2012

Abstract
By the request of the authors, the following two research articles will be retracted from the Journal of Cognitive Neuroscience:
1. Anderson, D. E., Ester, E. F., Klee, D., Vogel, E. K., & Awh, E. (2014). Electrophysiological evidence for failures of item individuation in crowded visual displays. Journal of Cognitive Neuroscience, 26(10), 2298– 2309. https://dx.doi.org/10.1162/jocn_a_00649.
2. Anderson, D. E., Bell, T. A., & Awh, E. (2012). Polymorphisms in the 5-HTTLPR gene mediate storage capacity of visual working memory. Journal of Cognitive Neuroscience, 24(5), 1069–1076. https://dx.doi. org/10.1162/jocn_a_00207.
On August 1, 2015, the Office of Research Integrity (ORI) announced a settlement agreement with David E. Anderson, the Respondent (http://ori.hhs.gov/content/ case-summary-anderson-david). On the basis of the Respondent’s admission and an analysis by the University of Oregon, ORI concluded that the Respondent had engaged in research misconduct by falsifying and/or fabricating data in four publications. Those publications were retracted immediately after the release of the ORI findings.
Since that time, additional problems have been discovered with Article 1 above. Data points shown in Figure 8 were removed without justification and in contradiction to the analytic approach described in the methods and results. In light of this discovery and of the previous ORI findings, authors Bell and Awh no longer have confidence in the integrity of the data in Article 2. For these reasons, all authors on both articles (including the Respondent) have agreed to the retraction of Articles 1 and 2 above.
Changes in the Observed Trends in Extreme Temperatures over China around 1990
Authors: Qi Li , Wang Yuqing 
Published: February 2012

Abstract
Based on the daily temperature data from weather stations in China, linear trends of the seasonal mean and extreme temperatures in summer and winter are analyzed and compared for the periods of 1960–89 and 1990–2009. The results show prominent changes in those trends since the early 1990s, in particular in winter—a signal of climate shift as previously identified. The changes, however, are found to be strongly region dependent.
In summer, both seasonal mean and extreme temperatures show a considerable cooling trend in central China and a warming trend in north and south China before 1990. After 1990 all temperature indices show significant warming trends throughout China with the largest trend up to 4.47°C (10 yr)−1 in north China. In winter in north China, with the most prominent warming trend during 1960–89, there is a significant cooling trend in both the seasonal mean temperature and the cold temperature indices after 1990. The warming trends over the Tibetan Plateau are substantially enhanced since 1990. All indices for the diurnal temperature range (DTR) show consistent decreasing trends in both summer and winter throughout China before 1990 while they turn to increasing trends in northeast China in summer and over the Tibetan Plateau in winter after 1990. The annual temperature range displays a decreasing trend throughout China before 1990 while it is dominated by an increasing trend after 1990 except over the Tibetan Plateau and in a narrow band along the Yangtze River. Possible mechanisms for the observed trend changes are discussed.
What is a mental illness? Public views and their effects on attitudes and disclosure
Authors: Rüsch Nicolas , Evans-Lacko Sara , Thornicroft Graham 
Published: February 2012

Objective: ‘Mental illness’ is a common label. However, the general public may or may not consider various conditions, ranging from major psychiatric disorders to stress, as mental illnesses. It is unclear how such public views affect attitudes towards people with mental illness and reactions to one’s own potential mental illness, e.g. in terms of help-seeking or disclosure. Methods: In representative English population surveys the classification of six conditions (schizophrenia, bipolar disorder, depression, drug addiction, stress, grief) as a mental illness was assessed as well as attitudes towards, and contact with, people with mental illness, intentions to disclose a mental illness and to seek treatment. Results: A factor analysis of how strongly respondents perceived the six conditions as a mental illness yielded two factors: (i) major psychiatric disorders and (ii) stress- and behaviour-related conditions including drug addiction. In regression analyses, higher scores on the first, but not the second, factor predicted less perceived responsibility of people with mental illness for their actions, and more support for a neurobiological illness model and help-seeking. Classifying stress-related/behaviour-related conditions as mental illnesses, as well as not referring to major psychiatric disorders as mental illnesses, was associated with more negative attitudes and increased social distance, but also with stronger intentions to disclose a mental illness to an employer. Negative attitudes and social distance were also related to ethnic minority status and lower social grade. Conclusions: Referring to major psychiatric disorders as mental illnesses may reflect higher mental health literacy, better attitudes towards people with mental illness and help-seeking. A broader concept of mental illness could, although increasing negative attitudes, facilitate disclosure in the workplace. Public views on what is a mental illness may have context-dependent effects and should be taken into account in anti-stigma campaigns.