bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biochemical and Genetic Evidence for a SAP-PKC-θ Interaction Contributing to IL-4 Regulation
Authors: Cannons Jennifer L. , Wu Julie Z. , Gomez-Rodriguez Julio , Zhang Jinyi , Dong Baoxia , Liu Yin , Shaw Stephen , Siminovitch Katherine A. , Schwartzberg Pamela L. 
Published: July 2010

Abstract
Signaling lymphocytic activation molecule-associated protein (SAP), an adaptor molecule that recruits Fyn to the signaling lymphocytic activation molecule (SLAM) family of immunomodulatory receptors, is mutated in X-linked lymphoproliferative disease. CD4+ T cells from SAP-deficient mice have defective TCR-induced and follicular Th cell IL-4 production and impaired T cell-mediated help for germinal center formation; however, the downstream intermediates contributing to these defects remain unclear. We previously found that SAP-deficient CD4+ T cells exhibit decreased protein kinase C (PKC)-θ recruitment upon TCR stimulation. We demonstrate in this paper using GST pulldowns and coimmunoprecipitation studies that SAP constitutively associates with PKC-θ in T cells. SAP–PKC-θ interactions required R78 of SAP, a residue previously implicated in Fyn recruitment, yet SAP’s interactions with PKC-θ occurred independent of phosphotyrosine binding and Fyn. Overexpression of SAP in T cells increased and sustained PKC-θ recruitment to the immune synapse and elevated IL-4 production in response to TCR plus SLAM-mediated stimulation. Moreover, PKC-θ, like SAP, was required for SLAM-mediated increases in IL-4 production, and, conversely, membrane-targeted PKC-θ mutants rescued IL-4 expression in SAP−/− CD4+ T cells, providing genetic evidence that PKC-θ is a critical component of SLAM/SAP-mediated pathways that influence TCR-driven IL-4 production.
Methamphetamine Causes Mitrochondrial Oxidative Damage in Human T Lymphocytes Leading to Functional Impairment
Authors: Potula Raghava , Hawkins Brian J. , Cenna Jonathan M. , Fan Shongshan , Dykstra Holly , Ramirez Servio H. , Morsey Brenda , Brodie Michael R. , Persidsky Yuri 
Published: July 2010

Abstract
Methamphetamine (METH) abuse is known to be associated with an inordinate rate of infections. Although many studies have described the association of METH exposure and immunosuppression, so far the underlying mechanism still remains elusive. In this study, we present evidence that METH exposure resulted in mitochondrial oxidative damage and caused dysfunction of primary human T cells. METH treatment of T lymphocytes led to a rise in intracellular calcium levels that enhanced the generation of reactive oxygen species. TCR-CD28 linked calcium mobilization and subsequent uptake by mitochondria in METH-treated T cells correlated with an increase in mitochondrion-derived superoxide. Exposure to METH-induced mitochondrial dysfunction in the form of marked decrease in mitochondrial membrane potential, increased mitochondrial mass, enhanced protein nitrosylation and diminished protein levels of complexes I, III, and IV of the electron transport chain. These changes paralleled reduced IL-2 secretion and T cell proliferative responses after TCR-CD28 stimulation indicating impaired T cell function. Furthermore, antioxidants attenuated METH-induced mitochondrial damage by preserving the protein levels of mitochondrial complexes I, III, and IV. Altogether, our data indicate that METH can cause T cell dysfunction via induction of oxidative stress and mitochondrial injury as underlying mechanism of immune impairment secondary to METH abuse.
Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes
Authors: Hill Lindsay M. , Gavala Monica L. , Lenertz Lisa Y. , Bertics Paul J. 
Published: July 2010

Abstract
Extracellular ATP has been proposed to act as a danger signal to alert the immune system of cell damage. Release of high local concentrations of ATP activates the nucleotide receptor, purinergic receptor X7 (P2RX7), on monocytic cells, which promotes the processing/release of proinflammatory mediators. Although the proinflammatory actions of P2RX7 are well recognized, little is known regarding the potential function of P2RX7 in repair responses. Because the resolution of inflammation is characterized by monocytic cell-dependent production of proangiogenic factors, we evaluated the contribution of P2RX7 to this process. We observed that both short-term and long-term P2RX7 activation promotes the robust release of vascular endothelial growth factor from primary human monocytes. This vascular endothelial growth factor release is calcium dependent and associated with reactive oxygen species production. This previously unrecognized action of P2RX7 suggests that it may not only participate in inflammation and cell death, but that it is also likely to be important in the control of angiogenesis and wound repair.
Absence of radiographic asbestosis and the risk of lung cancer among asbestos‐cement workers: Extended follow‐up of a cohort
Authors: Finkelstein Murray M. 
Published: July 2010

AbstractBackgroundIt has been a matter of controversy whether there is an increased risk of lung cancer among asbestos‐exposed workers without radiographic asbestosis. A previous study of lung cancer risk among asbestos‐cement workers has been updated with an additional 12 years of follow‐up.MethodsSubjects had received radiographic examination at 20 and 25 years from first exposure to asbestos. Radiographs were interpreted by a single National Institute of Safety and Health (NIOSH)‐certified B‐reader using the 1971 International Labor Office (ILO) Classification of the pneumoconioses as reference standard. Asbestosis was defined as an ILO coding of 1/0 or higher. Standardized Mortality Ratios (SMRs) were calculated using the general population of Ontario as reference.ResultsAmong asbestos‐cement workers without radiographic asbestosis at 20 years latency the lung cancer SMR was 3.84 (2.24–6.14). Among workers without asbestosis when examined at 25 years latency the SMR was 3.69 (1.59–7.26).ConclusionsWorkers from an Ontario asbestos‐cement factory who did not have radiographic asbestosis at 20 or 25 years from first exposure to asbestos continued to have an increased risk of death from lung cancer during an additional 12 years of follow‐up. Am. J. Ind. Med. 53:1065–1069, 2010. © 2010 Wiley‐Liss, Inc.
High performance bio‐based thermosetting resins composed of tung oil and bismaleimide
Authors: Shibata Mitsuhiro , Teramoto Naozumi , Nakamura Yu 
Published: July 2010

AbstractThe reaction of tung oil (TO) and 1,1′‐(methylenedi‐4,1‐phenylene)bismaleimide (BMI) in 1,3‐dimethyl‐2‐imidazolidinone (DMI) at 150°C for 4 h and subsequent precipitation gave TO/BMI prepolymer, which was cured at 200°C for 2 h gave crosslinked TO/BMI product with CC ratio from 1/1 to 1/4. The FE‐SEM analysis revealed that all the cured products are homogeneous and no phase separation was observed. The glass transition temperature and 5% weight loss temperature of the cured TO/BMI increased with increasing BMI content. The maximal tensile strength (38.1 MPa) and modulus (2.6 GPa) were obtained for the cured products with the CC ratios of 1/2 and 1/3, respectively. To evaluate the reaction of TO and BMI, the model reaction products of TO and N‐phenylmaleimide (PMI) in DMI were analyzed by 1H‐NMR spectroscopy. The NMR data of the reaction products of TO/PMI with the CC ratio 2/1, 1/1, 1/2, 1/3, and 1/4 at 150°C for 24 h revealed that Diels‐Alder reaction preferentially occurred at 2/1, and that ene reaction and other reactions such as radical homo and copolymerization gradually increased with decreasing CC ratio of TO/PMI. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Using a silanized silica nanofiller to reduce excessive amount of rubber curatives in styrene‐butadiene rubber
Authors: Ansarifar Ali , Wang Li , Ellis Robert J. , Haile‐Meskel Yared 
Published: July 2010

AbstractIn recent years, the rubber industry has come under pressure to improve health and safety at work, minimize damage to the environment, reduce costs, and increase competitiveness. Rubber compounds contain additives including curing chemicals, which are hazardous and harmful. Reducing their use or eliminating them altogether will be beneficial to rubber compounders and manufacturers of rubber articles. A styrene‐butadiene rubber (SBR) was cured and reinforced with a high loading of precipitated amorphous white silica nanofiller. The silica surfaces were pretreated with bis(3‐triethoxysilylpropyl) tetrasulfide (TESPT), which is a sulfur‐bearing bifunctional organosilane to chemically adhere silica to the rubber. The chemical bonding between the filler and rubber was optimized via the tetrasulfane groups of TESPT by adding accelerator and activator. The rubbers were subsequently cured and their hardness, tensile strength, elongation at break, stored energy density at break, tearing energy, tensile modulus, Young's modulus, and bound rubber content were measured. This study showed that using the filler in combination with a sulfur‐donor accelerator was the most efficient method for curing and reinforcing the rubber. This led to a significant reduction in the use of the curing chemicals, a faster curing cycle, and very good mechanical properties for the rubber vulcanizate. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Preparation and thermal properties of novel phthalonitrile oligomer containing biphenyl ethernitrile/bisphthalonitrile blends
Authors: Yang Xiaoli , Lei Yajie , Zhong Jiachun , Zhao Rui , Liu Xiaobo 
Published: July 2010

AbstractA kind of novel n = 2 phthalonitrile oligomer containing biphenyl ethernitrile (2PEN‐BPh) had been firstly synthesized from 2,6‐dichlorobenzonitrile, 4,4′‐biphenol and 4‐nitrophthalonitrile via solution reaction, and the 2PEN‐BPh was characterized by FTIR, 1H‐NMR spectra which exhibited that cyano groups and ethernitrile linkages existed in the backbone of 2PEN‐BPh. The 2PEN‐BPh oligomer was blended with bisphthalonitrile monomer, the curing reaction behaviors of the blends were studied by FTIR, DSC, and rheological analysis. The thermal and thermo‐oxidative stabilities of the 2PEN‐BPh/BPh polymers were investigated by TGA, and the results showed that the completely cured polymers could achieve char yields up to 78% at 800°C in nitrogen, above 11% at 800°C in air. The whole research indicated that the 2PEN‐BPh/BPh blends could efficiently improve the processability of BPh monomer without scarifying other desirable high temperature properties. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Designing robust rapid transit networks with alternative routes
Authors: Laporte Gilbert , Marín Angel , Mesa Juan A. , Perea Federico 
Published: July 2010

AbstractThe aim of this paper is to propose a model for the design of a robust rapid transit network. In this paper, a network is said to be robust when the effect of disruption on total trip coverage is minimized. The proposed model is constrained by three different kinds of flow conditions. These constraints will yield a network that provides several alternative routes for given origin–destination pairs, therefore increasing robustness. The paper includes computational experiments which show how the introduction of robustness influences network design. Copyright © 2010 John Wiley & Sons, Ltd.
Asset Legitimacy and Distributive Justice in the Dictator Game: An Experimental Analysis
Authors: Mittone Luigi , Ploner Matteo 
Published: July 2010

ABSTRACTDistributive justice seems to guide behavior in reward allocation tasks in which subjects in a group jointly produce an endowment that is then allocated by a member of the group. It has been shown that allocators aim to preserve the proportionality between inputs (e.g., effort) and outputs (e.g., monetary rewards) of those in the group, even when this comes at a cost to themselves. We experimentally investigated whether justice considerations of this kind play a role in a double‐blind dictator game when the assets to be allocated are generated exclusively through the effort of the decision maker. The experiment shows that distributive justice is an important source of motivation in highly demanding social environments in which reputational concerns and reciprocity are absent. This finding has been corroborated by an independent validity check and may have important implications for previous experimental findings and for the economics of charity. Copyright © 2010 John Wiley & Sons, Ltd.
The visceral yolk sac endoderm provides for absorption of nutrients to the embryo during neurulation
Authors: Zohn Irene E. , Sarkar Anjali A. 
Published: July 2010

AbstractNeural tube defects (NTDs) represent some of the most common congenital malformations in humans. The causes of NTDs are complex with both genetic and environmental contributing factors. Periconception nutrition is an important environmental factor influencing the penetrance of NTDs. NTDs arise from failure to close the neural tube completely during development, an event that occurs before establishment of the chorioallantoic placenta. During neurulation, nutrients are absorbed by histotrophic mechanisms and absorbed by endocytosis in the endoderm‐derived cell layer of the visceral yolk sac (VYS). Here we review the histotrophic mechanisms by which nutrients are delivered to the human embryo during this critical time period. Because more detailed studies on the molecular mechanisms regulating uptake of nutrients have been performed using rodent models, most importantly mouse and rat models, we will also review nutrient uptake in these model organisms to set the stage for presentation of experimental data that have provided valuable information about how nutrients are delivered to the neurulating embryo. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc.
Metabolic flux analysis of CHO cell metabolism in the late non‐growth phase
Authors: Sengupta Neelanjan , Rose Steven T. , Morgan John A. 
Published: July 2010

AbstractChinese hamster ovary (CHO) cell cultures are commonly used for production of recombinant human therapeutic proteins. Often the goal of such a process is to separate the growth phase of the cells, from the non‐growth phase where ideally the cells are diverting resources to produce the protein of interest. Characterizing the way that the cells use nutrients in terms of metabolic fluxes as a function of culture conditions can provide a deeper understanding of the cell biology offering guidance for process improvements. To evaluate the fluxes, metabolic flux analysis of the CHO cell culture in the non‐growth phase was performed by a combination of steady‐state isotopomer balancing and stoichiometric modeling. Analysis of the glycolytic pathway and pentose phosphate pathway (PPP) indicated that almost all of the consumed glucose is diverted towards PPP with a high NADPH production; with even recycle from PPP to G6P in some cases. Almost all of the pyruvate produced from glycolysis entered the TCA cycle with little or no lactate production. Comparison of the non‐growth phase against previously reported fluxes from growth phase cultures indicated marked differences in the fluxes, in terms of the split between glycolysis and PPP, and also around the pyruvate node. Possible reasons for the high NADPH production are also discussed. Evaluation of the fluxes indicated that the medium strength, carbon dioxide level, and temperature with dissolved oxygen have statistically significant impacts on different nodes of the flux network. Biotechnol. Bioeng. 2011; 108:82–92. © 2010 Wiley Periodicals, Inc.
ChemInform Abstract: Synthesis and Crystal Structure of New Layered BaNaSc(BO3)2 and BaNaY(BO3)2 Orthoborates.
Authors: Seryotkin Yurii V. , Bakakin Vladimir V. , Kokh Aleksandr E. , Kononova Nadezhda G. , Svetlyakova Tatyana N. , Kokh Konstantin A. , Drebushchak Tatyana N. 
Published: July 2010

AbstractCrystals of the title compounds are obtained by spontaneous crystallization from a melt of BaB2O4, NaBO2, and MBO3 (M: Sc, Y; Pt crucible, 950—930 °C).
ChemInform Abstract: Cooperative Jahn—Teller Distortion Leading to the Spin‐1/2 Uniform Antiferromagnetic Chains in Triclinic Perovskites AgCuF3 and NaCuF3.
Authors: Tong J. , Lee C. , Whangbo M.‐H. , Kremer R. K. , Simon A. , Koehler J. 
Published: July 2010

AbstractAgCuF3 is synthesized by solid state reaction of AgF and CuF2 (773 K, 3 d).
ChemInform Abstract: Synthesis of Alkali Metal Indium Thiophosphates Containing the Discrete Anions [In(PS4)(PS5)2]6‐ and [In(PS4)2(PS5)]6‐.
Authors: Rothenberger Alexander , Morris Collin , Kanatzidis Mercouri G. 
Published: July 2010

AbstractThe new thiophosphates (IIIa,c) crystallize in the triclic space group P$\bar 1$ with Z = 2 and (IIIb) in the monoclinic space group C2/c with Z = 4.
ChemInform Abstract: Synthesis and Crystal Structure of Ln2M2+Ge4O12, Ln: Rare‐Earth Element or Y; M: Ca, Mn, Zn.
Authors: Zubkov Vladimir G. , Tarakina Nadezda V. , Leonidov Ivan I. , Tyutyunnik Alexander P. , Surat Ludmila L. , Melkozerova Marina A. , Zabolotskaya Elena V. , Kellerman Dina G. 
Published: July 2010

AbstractThe title compounds are promising optical materials, in which different lanthanoid elements are introduced as a sensitizer or activator.
ChemInform Abstract: The Plumbide CeZnPb — Structure, Magnetism, and Chemical Bonding.
Authors: Hermes Wilfried , Rodewald Ute Ch. , Chevalier Bernard , Matar Samir F. , Eyert Volker , Poettgen Rainer 
Published: July 2010

AbstractThe new title compound is prepared from the elements (Ta‐tube, 1360 K, 25 min).
ChemInform Abstract: Cobalt, Manganese, Nickel, and Vanadium Derivatives of the Cyclic 48‐Tungsto‐8‐Phosphate [H7P8W48O184]33‐.
Authors: Keita Bineta , et al. et al. 
Published: July 2010

AbstractThe structures of the title compounds (IV) (triclinic, space group P$\bar 1$, Z = 1), (VI) (P$\bar 1$, Z = 1), and (VIII) (tetragonal, P4/m, Z = 2) are determined by single crystal XRD.
ChemInform Abstract: Crystal Structure and Electronic Properties of the New Compounds U3Co12‐xX4 with X: Si, Ge.
Authors: Soude A. , Tougait O. , Pasturel M. , Kaczorowski D. , Noel H. 
Published: July 2010

AbstractU6Co23.32Ge8 and U6Co23.5Si8 are prepared by melting of the elements followed by annealing at 1173 K for 14 d.
ChemInform Abstract: Lanthanum Doped BiFeO3 Powders: Syntheses and Characterization
Authors: Gonzalez Garcia F. , Riccardi C. S. , Simoes A. Z. 
Published: July 2010

AbstractSingle‐phase Bi1‐xLaxFeO3 powders with x = 0, 0.08, 0.15, and 0.30 are prepared by esterification of the corresponding metal citrates with ethylene glycol followed by decomposition of the organic residues at 300 °C and calcination at 850 °C (alumina crucible, 2 h).
ChemInform Abstract: Sulfonated N‐Heterocyclic Carbenes for Pd‐Catalyzed Sonogashira and Suzuki—Miyaura Coupling in Aqueous Solvents.
Authors: Roy Sutapa , Plenio Herbert 
Published: July 2010

AbstractWater‐soluble palladium catalyst complexes are successfully applied in the copper‐free Sonogashira coupling reaction and Suzuki—Miyaura coupling in alcohol/water mixtures.
ChemInform Abstract: Chiral Primary Amine Mediated Conjugate Addition of Branched Aldehydes to Vinyl Sulfone: Asymmetric Generation of Quaternary Carbon Centers.
Authors: Zhu Qiang , Lu Yixin 
Published: July 2010

AbstractA novel threonine‐based N‐sulfonamide is prepared and efficiently applied as chiral catalyst for the enantioselective conjugate addition of aldehydes (II) to sulfone (I).
ChemInform Abstract: Tsuji—Trost Allylations with Palladium Recovery by Phosphines/Pd(0)‐Triolefinic Macrocyclic Catalysts.
Authors: Serra‐Muns Anna , Pleixats Roser 
Published: July 2010

AbstractA Pd(0)—triolefinic azamacrocycle complex efficiently catalyzes the Tsuji—Trost reaction of allylic carbonate (I) with various N‐ and O‐nucleophiles.
ChemInform Abstract: Ruthenium(IV) Complexes Featuring P,O‐Chelating Ligands: Regioselective Substitution Directly from Allylic Alcohols.
Authors: Sundararaju Basker , Achard Mathieu , Demerseman Bernard , Toupet Loic , Sharma Gangavaram V. M. , Bruneau Christian 
Published: July 2010

AbstractThe Ru complexes (I) and (II) efficiently promote regioselective allylation reactions.
ChemInform Abstract: Oxidant‐Free Lactonization of Diols Using a Hydrotalcite‐Supported Copper Catalyst.
Authors: Mikami Yusuke , Ebata Kaori , Mitsudome Takato , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi 
Published: July 2010

AbstractThe reaction proceeds with development of hydrogen; the catalyst can be recovered by simple filtration and reused without significant loss of activity.
ChemInform Abstract: An Expedient Procedure for the Oxidative Cleavage of Olefinic Bonds with PhI(OAc)2, NMO, and Catalytic OsO4.
Authors: Nicolaou K. C. , Adsool Vikrant A. , Hale Christopher R. H. 
Published: July 2010

AbstractTwo efficient methods for the oxidative cleavage of mono‐, di‐, and trisubstituted alkenes are reported.
ChemInform Abstract: Facile Oxidation of Electron‐Poor Benzo[b]thiophenes to the Corresponding Sulfones with an Aqueous Solution of H2O2 and P2O5.
Authors: Antonow Dyeison , Marrafa Teresa , Dawood Irfaan , Ahmed Tauheed , Haque Mohammad R. , Thurston David E. , Zinzalla Giovanni 
Published: July 2010

AbstractBenzo[b]thiophenes (I) and sulfides (III) are oxidized with aqueous peroxomonophosphoric acid to afford the corresponding sulfones (II) and (IV), resp., in good yields.
ChemInform Abstract: Synthesis of Salan (Salalen) Ligands Derived from Binaphthol for Titanium‐Catalyzed Asymmetric Epoxidation of Olefins with Aqueous H2O2.
Authors: Xiong Donglu , Wu Mei , Wang Shoufeng , Li Fuwei , Xia Chungu , Sun Wei 
Published: July 2010

AbstractA variety of olefins is efficiently transformed to the corresponding epoxides by Ti‐catalyzed asymmetric reaction using novel salan/salalen ligands, e.g. (I) or (II).
ChemInform Abstract: Chlorination of Various Substrates in Subcritical Carbon Tetrachloride.
Authors: Tanemura Kiyoshi , Suzuki Tsuneo , Nishida Yoko , Horaguchi Takaaki 
Published: July 2010

AbstractVarious aliphatic hydrocarbons and aromatic compounds including 1,4‐disubstituted benzenes are chlorinated using CCl4 under high‐temperature conditions.
ChemInform Abstract: Trifluoromethylation of Various Aromatic Compounds by CF3I in the Presence of Fe(II) Compound, H2O2 and Dimethylsulfoxide.
Authors: Kino Tatsuhito , Nagase Yu , Ohtsuka Yuhki , Yamamoto Kyoko , Uraguchi Daisuke , Tokushisa Kenji , Yamakawa Tetsu 
Published: July 2010

AbstractThe trifluoromethylation of aromatic and heteroaromatic compounds is carried out by using a reagent composition consisting of Fe(II), hydrogen peroxide, and dimethylsulfoxide in the presence or absence of sulfuric acid.
ChemInform Abstract: Reaction Behavior of Cumulene: Diels—Alder, Friedel—Crafts, and Pd‐Catalyzed Domino Reactions.
Authors: Asakawa Tomohiro , Iinuma Mie , Wakasugi Yuko , Kuno Mayumi , Furuta Takumi , Fujii Satoshi , Tanaka Kiyoshi , Kan Toshiyuki 
Published: July 2010

AbstractCharacteristic Diels—Alder [(I)→(III)+(IV)] and Friedel—Crafts [(I)→(VI)+(VII)] type conjugate addition reactions of methyldiphenylpentatrienal (I) are found, providing novel and useful routes to highly substituted allene and diene derivatives.
ChemInform Abstract: Mild Deprotection of Methylene Acetals in Combination with Trimethylsilyl Triflate‐2,2′‐bipyridyl.
Authors: Fujioka Hiromichi , Senami Kento , Kubo Ozora , Yahata Kenzo , Minamitsuji Yutaka , Maegawa Tomohiro 
Published: July 2010

AbstractThe presented method tolerates acid‐sensitive functional groups.
ChemInform Abstract: Negishi Alkyl—Aryl Cross‐Coupling Catalyzed by Rh: Efficiency of Novel Tripodal 3‐Diphenylphosphino‐2‐(diphenylphosphino)methyl‐2‐methylpropyl Acetate Ligand.
Authors: Ejiri Syogo , Odo Shunsuke , Takahashi Hideki , Nishimura Yugo , Gotoh Kazuma , Nishihara Yasushi , Takagi Kentaro 
Published: July 2010

AbstractThe reaction is effective for the aromatic zinc derivatives bearing electron‐withdrawing substituents, while poor yields are observed for the electron‐donating and unsubstituted substrates [cf.