bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal key forwarding strategy in QKD behaviours
Authors: Popa Alin-Bogdan , Popescu Pantelimon George 
Published: June 2024

AbstractNowadays QKD plays a critical role in unconditionally-secure and quantum-safe key distribution. Commercially available QKD devices are getting more popular for institutional and governmental national and international networks, but are expensive and offer limited key rates. We provide a formalization of QKD-generated key forwarding and redistribution at the KMS level by extending the network graph of physical QKD links to the complete graph with logical links, and we investigate its application on three practical scalable scenarios (all-to-all, one-to-all, one-to-one). We define a maximization goal for each scenario, and provide a linear programming problem statement to compute the optimal redistribution. We perform an extensive analysis of the algorithm in terms of forwarding results and key consumption on simulated QKD networks and discuss the implications of network size and graph topology on the algorithm’s performance and complexity.
Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment
Authors: Erramilli Satchal K. , Dominik Pawel K. , Ogbu Chinemerem P. , Kossiakoff Anthony A. , Vecchio Alex J. 
Published: June 2024

AbstractClaudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular spaces between endothelial and epithelial cells. As the backbone of tight junction structure and function, claudins are attractive targets for modulating tissue permeability to deliver drugs or treat disease. However, structures of claudins are limited due to their small sizes and physicochemical properties—these traits also make therapy development a challenge. Here we report the development of a synthetic antibody fragment (sFab) that binds human claudin-4 and the determination of a high-resolution structure of it bound to claudin-4/enterotoxin complexes using cryogenic electron microscopy. Structural and biophysical results reveal this sFabs mechanism of select binding to human claudin-4 over other homologous claudins and establish the ability of sFabs to bind hard-to-target claudins to probe tight junction structure and function. The findings provide a framework for tight junction modulation by sFabs for tissue-selective therapies.
Dissociable effects of dopaminergic medications on depression symptom dimensions in Parkinson disease
Authors: Costello Harry , Schrag Anette-Eleonore , Howard Robert , Roiser Jonathan P. 
Published: June 2024

AbstractDepression in Parkinson disease (PD) is common, is disabling and responds poorly to standard antidepressants. Motivational symptoms of depression are particularly prevalent in PD and emerge with loss of dopaminergic innervation of the striatum. Optimizing dopaminergic treatment for PD can improve depressive symptoms. However, the differential effect of antiparkinsonian medication on symptom dimensions of depression is not known. Using data from a large (n = 412) longitudinal study of patients with newly diagnosed PD followed over 5 years, we investigated whether there are dissociable effects of dopaminergic medications on different depression symptom dimensions in PD. Previously validated ‘motivation’ and ‘depression’ dimensions were derived from the 15-item geriatric depression scale. Dopaminergic neurodegeneration was measured using repeated striatal dopamine transporter imaging. We identified dissociable associations between dopaminergic medications and different dimensions of depression in PD. Dopamine agonists were shown to be effective for treatment of motivational symptoms of depression. In contrast, monoamine oxidase-B inhibitors improved both depressive and motivation symptoms, albeit the latter effect is attenuated in patients with more severe striatal dopaminergic neurodegeneration.
DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer
Authors: Momeny Majid , Tienhaara Mari , Sharma Mukund , Chakroborty Deepankar , Varjus Roosa , Takala Iina , Merisaari Joni , Padzik Artur , Vogt Andreas , Paatero Ilkka , Elenius Klaus , Laajala Teemu D , Kurppa Kari J , Westermarck Jukka 
Published: June 2024

AbstractDespite clinical benefits of tyrosine kinase inhibitors (TKIs) in cancer, most tumors can reactivate proliferation under TKI therapy. Here we present transcriptional profiling of HER2+ breast cancer cells transitioning from dormant drug tolerant cells to re-proliferating cells under continuous HER2 inhibitor (HER2i) therapy. Focusing on phosphatases, expression of dual-specificity phosphatase DUSP6 was found inhibited in dormant cells, but strongly induced upon regrowth. DUSP6 expression also selectively associated with poor patient survival in HER2+ breast cancers. DUSP6 overexpression conferred apoptosis resistance, whereas its pharmacological blockade prevented therapy tolerance development under HER2i therapy. DUSP6 targeting also synergized with clinically used HER2i combination therapies. Mechanistically DUSP6 is a positive regulator of HER3 expression, and its impact on HER2i tolerance was mediated by neuregulin-HER3 axis. In vivo, genetic targeting of DUSP6 reduced tumor growth in brain metastasis model, whereas its pharmacological targeting induced synthetic lethal therapeutic effect in combination with HER2i. Collectively this work demonstrates that DUSP6 drives escape from HER2i-induced dormancy, and that DUSP6 is a druggable target to overcome HER3-driven TKI resistance.
Vorspeise für Tierärzte 2.0
Authors: von Bremen Dörte 
Published: June 2024

Liebe Leserin, lieber Leser,für diese Ausgabe der ZGTM bin ich als Greenhorn verantwortlich, die allererste Seite
mit dem Editorial zu bestücken. Das klang bei der Diskussion im Editoren-Team
unspektakulär, und bei der beiläufigen Ansage „Eine halbe, vielleicht eine
dreiviertel Seite als Intro schreiben“, dachte ich „pfff, des is a gmahde Wiesn“ wie
man bei uns in Bayern sagt.
Pediatric Gastrointestinal Interventions
Authors: Chennapragada S. Murthy 
Published: June 2024

AbstractImage-guided interventions are increasingly being used in the management of many pediatric disease processes since they provide safe and effective minimally invasive treatment options. This review article attempts to provide an overview of the commonly performed interventions in the gastrointestinal tract in children. These include esophageal balloon dilatation, establishment and maintenance of gastroenteral access, and hepatobiliary interventions (liver biopsy, percutaneous cholangiogram, and biliary drainage).
Impact of academic title structure of university research teams on research output: evidence from 30 Chinese universities
Authors: Zhang Mengmeng , Liu Liyuan , Zeng Dongmei , Li Xiaoying 
Published: June 2024

AbstractDespite widespread agreement in the scholarly community about the significance of academic title structure on research output, research on the underlying mechanisms remains insufficient. Social contribution and research resources were selected as mediating variables, panel data of the materials science and engineering discipline of 30 Chinese universities from 2016 to 2020 were chosen as the research samples, and a fixed-effects model was subsequently applied to conduct a chain mediating effect test. The results showed: (1) Both the proportion of national-level talents and that of senior titles can promote research output, with the former having a much greater effect, while the proportion of associate senior titles has an indistinctive negative correlation with research output. (2) Both the proportion of national-level talents and that of senior titles can significantly enhance research output through the chain mediating effect of social contribution and research resources, with national-level talents having a stronger ability to make social contributions and obtain research resources. (3) Social contribution is more effective than research resources in enhancing research output. Based on the findings, it is recommended to improve policies for introducing high-end talents and to increase support for researchers with associate senior titles. Furthermore, it is advisable to establish a research evaluation system based on social influence, guiding researchers to obtain research resources and enhance research output through social contributions.
Enhancing photon recycling of perovskite nanosheet by two-photon excitation
Authors: Li Yuanyuan , Xie Jiaxin , Sun Yu , Zhang He , Xia Chuansheng , Wang Min , Wang Tianjie , Chang Jianhua , Cui Qiannan 
Published: June 2024

Nanometer scale light penetration depths of halide perovskite (HP) set an intrinsic limit on the performance improvement of optoelectronic devices. Here, we show that two-photon excitation can overcome this limit by markedly increasing the light penetration depth and significantly enhance photon recycling. Through a comparison study between one-photon and two-photon excitations by femtosecond laser pulses in a CsPbBr3 nanosheet, our results demonstrate that two-photon excitation can increase photocarrier transport distance by about 900 nm, which is even comparable to the photocarrier diffusion length. Our work provides substantial insights into the photon recycling of HP induced by nonlinear optical excitations, which can benefit the performance optimization of advanced optoelectronic devices.
Temporal trends in medical device implant procedures in Australia 2008–22: evidence from the Australian Institute of Health and Welfare National Hospital Morbidity database
Authors: Ali Mohammad Afshar , Kelly Thu-Lan , Gillam Marianne 
Published: June 2024

Objective Examine the temporal trends in medical device implant procedures in the Australian population. Methods We used data from the Australian Institute of Health and Welfare from the financial years 2007–08 to 2021–22 and chose the most frequently performed medical device implant procedures. We estimated the annual change in volume of procedures and age-standardised rates by calculating the compound annual growth rate (CAGR), and used regression with the Newey–West robust variance estimator to examine whether there was a linear trend in the age-standardised rates for each procedure. Results For procedures including cardiac pacemakers, heart valves, hip and knee arthroplasties, and intraocular lenses, the crude CAGR was over 3%. For the age-standardised rates, the CAGR was largest for cardiac pacemaker, followed by heart valve replacement and hip arthroplasty procedures. For some procedures, the growth was more than in the Australian population, including cardiac pacemakers (β = 1.00; 95% CI: 0.14–1.86), heart valve replacements (β = 0.41; 95% CI: 0.28–0.54), hip arthroplasty (β = 3.50; 95% CI: 1.61–5.38), and knee arthroplasty (β = 4.31; 95% CI: 0.54–8.09) procedures. The trend of standardised rates of procedures, including incisional hernia with mesh, breast implants, coronary stents, and cardiac defibrillators, grew at the same rate as the population, whereas the rate for gastric banding procedures decreased (β = −3.14; 95% CI: −4.92 to −1.34). Conclusion The findings from the current study, showing a large increase in medical device implant procedures, will assist in future healthcare planning and efforts in post-market surveillance of safety of medical devices.
Can condensed tannins improve fermentation patterns and the nutritive value of sorghum silage?
Authors: Souza E. J. O. , Rodrigues J. M. C. S. , Silva J. R. C. , Torres T. R. , Santos M. V. F. , Silva D. K. A. , Sobral G. C. , Santos Neto E. L. , Oliveira O. F. 
Published: June 2024

Context For an ensiling to succeed, the knowledge about the factors that might influence the fermentation dynamics and nutrient loss is mandatory. One of the strategies is the use of additives such as tannins, as they can decrease proteolysis and increase the total organic acids. Aims The aim was to investigate the effects of tannins on fermentation patterns and nutritional value of sorghum silage. Methods Silages containing 0.0, 7.5, 15.0, 22.5, and 30.0 g/kg of tannin on fresh matter were studied. To produce the silage, the tannin was added to the forage and manually homogenised before ensiling. The study was conducted in three experiments. In the first experiment, five replications of each level of inclusion were produced and assigned in a completely randomised design. The chemical composition and fermentation patterns of all experimental units were evaluated. The second experiment consisted of analysing the aerobic deterioration by using a PET bottles system. This experiment was conducted in a completely randomised split plot, with five replications and five treatments with the inclusion of different levels of tannin (main plots) and the hours of exposure of silage to air (subplot). In the third experiment, five levels of tannin (main plots) and incubation times (subplots) were evaluated as for in situ digestibility (ruminal degradability) in a randomised blocks design with three replications (animals). Key results The inclusion of tannins in sorghum silage caused quadratic effects on pH, acetic acid, lactic acid, total organic acids, ammonia nitrogen, dry matter content, crude protein content and in situ digestibility, when the level varied from 10.5 to 22.7 g tannin/kg fresh matter. There was a decreasing linear effect for aerobic deterioration as increasing levels of tannin in sorghum silage. Conclusions The inclusion of tannin as an additive in sorghum silage is recommended for the production of good quality silage. The use of condensed tannins optimise fermentation patterns (especially increasing lactic acid and decreasing ammoniacal nitrogen), chemical composition, providing less aerobic deterioration and improve digestibility. Implications This study revealed that condensed tannins can improve fermentation patterns and the nutritive value of sorghum silage.
Selection for growth rate at pasture in Angus cattle results in heavier cattle that eat more in the feedlot
Authors: Herd R. M. , Oddy V. H. , Arthur P. F. , McDonagh M. B. 
Published: June 2024

Context Selection for growth rate has received considerable attention in beef cattle but the evidence for an improvement in the efficiency of feed conversion is equivocal. Aim To examine whether feed efficiency by beef cattle finished in a feedlot had been changed in response to divergence selection for growth rate. Methods The Angus cattle used came from three lines of cattle selected for over five generations for fast growth rate to yearling age (High-line), slow growth (Low-line), or from an unselected Control-line. Over sequential years, a cohort of steers, then of heifers and then of steers, representative of the lines, were measured for feedlot performance, and carcase- and meat-quality traits. The animals were fed a high-energy feedlot ration and after an adjustment period they underwent a performance test of at least 70 days of duration. After slaughter, muscle samples were taken for subsequent measurement of the components of the endogenous calpain proteolytic enzyme system. Their carcasses underwent a standard chiller assessment and meat samples were taken after 1 day and 14 days (steers) or 17 days (heifers) for objective measurement of tenderness. Key results Cattle from the High-line grew 48% faster (P < 0.05), and ate 48% more feed (P < 0.05) than did those from the Low-line, but had similar (P > 0.05) feed conversion ratio and residual feed intake. There were no differences between the High-line and Low-line in the visual meat-quality attributes of meat colour, fat colour and marbling, and no differences in the objective measurements of tenderness and connective-tissue toughness. There was no evidence of a selection response in the circulating concentrations of the metabolites and hormones measured, nor in the endogenous calpain proteolytic enzyme system in muscle. Conclusions The superior growth demonstrated by the High-line cattle over the feedlot test was accompanied by a higher feed intake, with no evidence for an improvement in feed efficiency. Implications Selection for growth rate is a powerful tool to alter animal performance but the beef industry needs to be cognisant of the proportional increase in feed requirement from breeding bigger animals.
The role of thermal and squeezed photons in the entanglement dynamics of the double Jaynes–Cummings model
Authors: Mandal Koushik , Radhakrishnan Chandrashekar , Satyanarayana M V 
Published: June 2024

Abstract
The effects of squeezed photons and thermal photons on the entanglement dynamics of atom-atom, atom-field and field-field subsystems are studied for the double Jaynes–Cummings model. For this purpose, squeezed coherent states and Glauber-Lachs states of radiation are chosen as field states. For the atomic states, we choose one of the Bell state as pure state and a Werner-type state as mixed state. Werner-type state is used to understand the effects of mixedness on entanglement. To measure the entanglement between the two atoms, Wootters’ concurrence is used; whereas for the atom-field and field-field subsystems, negativity is chosen. The squeezed photons and thermal photons create, destroy and transfer entanglement within various subsystems. Also, the addition of squeezed photons and thermal photons either lengthens or shortens the duration of entanglement sudden deaths (ESD) associated with atom-atom, atom-field and field-field entanglement dynamics in a complementary way. The effects of Ising-type interaction, detuning and Kerr-nonlinearity on the entanglement dynamics are studied. Each of these interactions removes the ESDs associated with various subsystems. We show that new entanglements are created in this atom-field system by introducing Ising-type interaction between the two atoms. With proper choice of the parameters corresponding to Ising-type interaction, detuning and Kerr-nonliearity, entanglement can be transferred among various subsystems.
Universal basic mass density inside dark matter halos
Authors: Haddad Nidal , Haddad Fateen 
Published: June 2024

Abstract
In this work we propose a universal basic mass density and a universal basic metric inside dark matter halos in the framework of Einstein equations providing an analytical ground for learning about dark matter. In a previous work the authors have proposed a simplified model for galaxies: a Schwarzschild black hole (that contains all the baryonic matter of the Galaxy) immersed inside a dark matter halo. The solution solved the Einstein equations perturbatively and successfully gave the flat rotation curve and the baryonic Tully-Fisher relation, the two signatures of spiral galaxies. In this work we take the black hole mass (the baryonic mass) of the solution to be zero in order to focus our study on the dark matter halo exclusively. Among the results (1) is the prediction of a universal basic mass density of dark matter, ρ = a
0/2π
Gr, where a
0 ≈ 2.8 × 10−11 m s
−2 is a universal constant whose value was deduced from observations, (2) we show that the mass and velocity curve of the dark halo agree excellently with observational data at intermediate distances where the baryonic matter contribution is negligible, (3) we show that the constant a
0 is the origin of the constant surface density of dark matter and the origin of the scale-radius/scale-density scaling relation of the Navarro-Frenk-White profile (4) we show how the inclusion of baryonic matter in our model solves the core-cusp problem.
Design and experiment of high-performance small magnetic shielding box
Authors: Zhao Xiuqi , Liu Yan , Zhang Lu , Li Xianhong , Zhang Xu , Ye Xiangyang , Zhang Haifeng , Wu Haoting , Sun Jinji 
Published: June 2024

Abstract
Investigating the state of cells in zero magnetic or near-zero magnetic environments is an important scientific issue. However, standard cell culture incubators can only provide general conditions such as constant temperature, constant humidity, sterility, and carbon dioxide, and cannot provide zero magnetic or near-zero magnetic environments for cell culture. To address this issue, an optimization method was proposed in this paper based on the combination of the particle swarm optimization algorithm (PSO) and the finite element method (FEM), achieving the optimization design of a magnetic shielding box (MSB) with a small volume, high shielding factor, and low residual field. Firstly, the high-permeability layer and high-conductivity layer were optimized respectively using the PSO and FEM. Then, the effectiveness of this method was analyzed through experiments. The experimental results show that the shielding factors in three directions at the center point of the optimized MSB are 786.8 (east-west), 2182.7 (north-south), and 1389.4 (vertical) respectively at 0.01 Hz. Meanwhile, the maximum residual field in the cubic region with a side length of 10 cm inside the MSB is 11.9 nT. Finally, the MSB designed by this method was placed in a standard cell culture incubator to cultivate cells in a zero-magnetic or near-zero magnetic environment. Then the Cell Counting Kit-8 (CCK8) experiments to evaluate the cytotoxicity of chemotherapy drugs on tumor cells in a weak magnetic environment (WMF). The results show that the lethality of paclitaxel (PTX) to Epidermal carcinoma cell (A431) increases by 25.96 times and the lethality of gemcitabine (GE) to Lung carcinoma cell (NCI-H460) increases by 24.23 times in a WMF. At the same time, the maximum proliferation inhibition rate of 5-fluorouracil (5-FU) on NCI-H460 cells in a WMF environment increased by 15.69%. That is, WMF could significantly improve the therapeutic effect of chemotherapy drugs on tumor cells.
Probing New physics with high-redshift quasars: axions and non-standard cosmology
Authors: Sun Chen , Buen-Abad Manuel A. , Fan JiJi 
Published: June 2024

Abstract
The Hubble diagram of quasars, as candidates to “standardizable” candles, has been used to measure the expansion history of the Universe at late times, up to very high redshifts (z ∼ 7). It has been shown that this history, as inferred from the quasar dataset, deviates at ≳ 3σ level from the concordance (ΛCDM) cosmology model preferred by the cosmic microwave background (CMB) and other datasets. In this article, we investigate whether new physics beyond ΛCDM (BΛCDM) or beyond the Standard Model (BSM) could make the quasar data consistent with the concordance model. We first show that an effective redshift-dependent relation between the quasar UV and X-ray luminosities, complementing previous phenomenological work in the literature, can potentially remedy the discrepancy. Such a redshift dependence can be realized in a BSM model with axion-photon conversion in the intergalactic medium (IGM), although the preferred parameter space is in tension with various other astrophysical constraints on axions, at a level depending on the specific assumptions made regarding the IGM magnetic field. We briefly discuss a variation of the axion model that could evade these astrophysical constraints. On the other hand, we show that models beyond ΛCDM such as one with a varying dark energy equation of state (wCDM) or the phenomenological cosmographic model with a polynomial expansion of the luminosity distance, cannot alleviate the tension. The code for our analysis, based on emcee [1] and corner.py [2], is publicly available at github.com/ChenSun-Phys/high_z_candles.