bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of Patients with Drug‐Induced Atrioventricular Block
Authors: OSMONOV DAMIRBEK , ERDINLER IZZET , OZCAN KAZIM SERHAN , ALTAY SERVET , TURKKAN CEYHAN , YILDIRIM ERSIN , HASDEMIR HAKAN , ALPER AHMET TAHA , CAKMAK NAZMIYE , SATILMIS SECKIN , GURKAN KADIR 
Published: April 2012

Objective:

To identify the frequency of atrioventricular (AV) conduction improvement after discontinuation of the culprit drug in patients with AV block.
Background:

AV blockers are considered as reversible causes of AV block that do not require pacemaker (PM) implantation. However, controversial reports declared that a major part of these drug‐induced AV blocks are persistent or recurrent.
Methods:

Of 668 consecutive patients with symptomatic type II second‐ or third‐degree AV block, 2:1 AV block, atrial fibrillation, and bradyarrhythmia, 108 patients (62 patients enrolled prospectively) using AV blockers without myocardial infarction, electrolyte abnormalities, digitalis toxicity, and vasovagal syncope were enrolled into the present study. The level of AV block (AV‐nodal or infranodal) was defined according to electrocardiographic characteristics.
Results:

The most frequent culprit medications were β‐blockers followed by digoxin. Drug discontinuation was followed by resolution of AV block in 72% of cases, whereas spontaneous resolution of AV block occurred in only 6.6% of patients who had AV block in the absence of medications. However, 27% of patients with improved AV conduction experienced a recurrence of AV block despite discontinuation of the culprit drug. Twenty‐one of 24 carvedilol‐induced AV blocks resolved after discontinuation of the drug and never recurred, whereas 24 of 36 metoprolol‐induced AV blocks persisted or recurred. A digoxin‐induced AV block usually improved (28 of 39) after withdrawal of the drug. Roughly half of the patients with drug‐induced AV block underwent permanent PM implantation.
Conclusion:

Drug‐induced AV block is a serious disease that requires a permanent PM for almost half of the patients.
(PACE 2012;XX:1–7)
Direct Coagulation Casting of Positively Charged Alumina Suspension by Controlled Release of High Valence Counter Ions from Calcium Phosphate
Authors: Xu Jie , Wen Ning , Qi Fei , Li Hexin , Yang Jinlong 
Published: April 2012

The idea of controlled release of high valence counter ions was used in direct coagulation casting of ceramics. Calcium phosphate was used as the high valence counter ions source. Influence of the content of calcium phosphate on the viscosity of the suspension with positive charge on particles and the properties of green body were investigated. The results show that the content of calcium phosphate which leads to coagulation of suspension is 0.15–0.2 wt%. The pH changes from acidic regime to basic regime after calcium phosphate addition. Hydrochloric acid is consumed and CaHPO4, Ca(H2PO4)2, and CaCl2 are generated. The electrical double layer of alumina particles is strongly compressed by Ca2+ ions, leading to rapid increase of viscosity. Also, the pH value at high temperature approaches to isoelectric point of alumina and contributes to the instability of suspension. The optimum coagulated temperature is 60°C with coagulation time of 135 min. The compressive strength of green body is up to 2.8 MPa.
Qualitative bone CT as a tool to assess vascularization in irradiated bone: an animal study
Authors: Lethaus Bernd , Poort Lucas , Yamauchi Kensuke , Kloss‐Brandstätter Anita , Boeckmann Roland , Kessler Peter 
Published: April 2012

AbstractObjectiveThe purpose of this paper was to find a correlation between laser doppler flowmetry (LDF) and the bone mineral density quotient (BMDQ) to evaluate irradiated bone quality preoperatively.Materials and methodsPremolars and molars were extracted from six minipigs. After a three‐month healing period, three animals received irradiation at a total dose of 24 Gy. Three months after irradiation, quantitative computed tomography was performed using a calibration bone phantom to determine the 120‐position BMDQ in the alveolar bone. A drill template was created to define the exact location for measurement. LDF was then recorded after osteotomy of the residual alveolar ridge. The correlation between the BMDQ and LDF was investigated.ResultsThere was a linear negative correlation between LDF and BMDQ in non‐irradiated bone (r = −0.435, P = 0.001) and less pronounced also in irradiated bone (r = −0.309, P = 0.017).In both non‐irradiated and irradiated bone, we found distinct differences between the maxilla and mandible with respect to BMDQ. However, a clear difference in mandibular and maxillary vascularity was only seen in non‐irradiated bone.ConclusionIn non‐irradiated bone, LDF and BMDQ were inversely correlated. In irradiated bone, the BMDQ alone is not an adequate preoperative tool for evaluating bone quality because it was not correlated with bone perfusion.
Lipopolysaccharide induces rapid loss of follicular dendritic cell‐secreted protein in the junctional epithelium
Authors: Oshiro A. , Iseki S. , Miyauchi M. , Terashima T. , Kawaguchi Y. , Ikeda Y. , Shinomura T. 
Published: April 2012

Oshiro A, Iseki S, Miyauchi M, Terashima T, Kawaguchi Y, Ikeda Y, Shinomura T. Lipopolysaccharide induces rapid loss of follicular dendritic cell‐secreted protein in the junctional epithelium. J Periodont Res 2012; 47: 689–694. © 2012 John Wiley & Sons A/SBackground and Objective:  We have previously reported that mRNA encoding follicular dendritic cell‐secreted protein (FDC‐SP) is expressed specifically in the junctional epithelium at the gingival crevice. Other tissues, such as tonsil, prostate gland and trachea, also express high levels of FDC‐SP. These tissues participate in a range of functions closely related to innate immunity. Therefore, it is hypothesized that FDC‐SP plays a crucial role in close association with the host defense system within the gingival crevice. Accordingly, the main aim of this study was to investigate the expression and localization of FDC‐SP in and around the junctional epithelium and to observe the dynamic changes of FDC‐SP in experimental inflammation.Material and Methods:  We examined, immunohistochemically, the expression of FDC‐SP in the junctional epithelium using a specific antibody raised in rabbit after immunization with a synthetic peptide derived from the hydrophilic region of FDC‐SP. Experimental inflammation was induced in the upper molars of Wistar rats by applying bacterial lipopolysaccharide (LPS; 5 mg/mL in sterile saline) for 1 h.Results:  We confirmed that FDC‐SP is present in the junctional epithelium in a pattern that is consistent with the expression of FDC‐SP mRNA. Of special interest is that no FDC‐SP was detectable in the junctional epithelium 3 h after transient topical treatment with LPS.Conclusion:  The presence of FDC‐SP in the junctional epithelium and its loss after LPS treatment strongly support our hypothesis of FDC‐SP playing a crucial role in close association with the host defense system within the gingival crevice.
Management of sunitinib adverse events in renal cell carcinoma patients: The Asian experience
Authors: ZHOU Aiping 
Published: April 2012

AbstractSunitinib is the gold standard of care for patients with metastatic renal cell carcinoma, demonstrating an overall survival benefit of over 2 years in a pivotal phase 3 trial of 750 patients. While sunitinib is generally well tolerated with most adverse events, manifesting as mild to moderate in severity and manageability, it has a distinctive adverse event profile that benefits from careful monitoring during treatment. As sunitinib gains widespread use across the globe, best practices are being developed for specific patient groups. This review will focus on the current clinical trial data in Asian populations and on the mechanism, incidence and management of selected sunitinib‐related adverse events, including hand‐foot syndrome, hypertension, proteinuria, cardiac toxicities, myelosupression, fatigue/asthenia, hypothyroidism, diarrhea and hepatotoxicity. Taken together, the developing body of literature reviewed here demonstrates that sunitinib is well tolerated in Asian patients and provides efficacy that is similar, if not superior, to other patient groups. Asian patients, like all patients, should begin treatment of sunitinib at 50 mg on Schedule 4/2 (4 weeks on treatment/2 weeks off). Prophylactic measures, good communication between patient and health‐care providers, and early, aggressive intervention at the development of adverse events can limit the dose reductions required and maximize both patients' response to treatment and their quality of life.
No association between transmembrane protein‐tyrosine phosphatase receptor type C (PTPRC) exon A 77C>G transversion and liver transplant rejection
Authors: Thude H. , Schipler A. D. , Treszl A. , Sterneck M. , Nashan B. 
Published: April 2012

SummaryThis study was carried out to evaluate the association between 77C>G transversion (rs17612648) in exon A of the PTPRC gene and liver transplant rejection. No significant differences in genotype and allele frequencies of the 77C>G transversion were detected between recipients without rejection (n = 106) and recipients with rejection (n = 104). In conclusion, there was no evidence for the contribution of the 77C>G transversion in susceptibility to liver transplant rejection in a Caucasian population.
QUALITY OF FISH SAUCE PRODUCTS FROM RECYCLED BY‐PRODUCTS FROM FISH GEL ANDKAMABOKOPROCESSING
Authors: TAKANO T. , SHOZEN K. , SATOMI M. , TAIRA W. , ABE H. , FUNATSU Y. 
Published: April 2012

ABSTRACTIn order to make effective reuse ofkamabokoprocessing wastes and to minimize the amount of waste disposal, the production of two kinds of fish sauces was tried on a small industrial scale from the wastes with or without the addition of the meat of deepsea smelt (Glossanodon semifasciatus). They were fermented for 6 months at room temperature using salt andkojimold. As a control, a fish sauce was also produced only from the deepsea smelt meat. The recovery of fish sauce from the initial mashed mixture ranged between 75 and 79%, depending on the ingredients in the three fish sauce products. The total nitrogen content of the waste sauce and the mixed sauce was lower than that of the control. The levels of the original additives tokamabokoproducts,β‐carotene and sorbic acid, were very low in these fish sauces. The taste‐active components of the waste sauce and mixed sauces were lower than those of the control. Sensory evaluation revealed that the former two waste sauces were less bitter and higher in saltiness than the control. However, no difference was found in umami taste between these products. These findings suggest that the wastes fromkamabokoprocessing factories could be reused as fish sauce for food condiments.PRACTICAL APPLICATIONSRecent development in the food industry in Japan has enabled the surimi‐based products to be mass produced and standardized even in the fish gel,kamabokotrade. However, a serious problem has arisen in the development ofkamabokoprocessing through the discharge of the wastes, i.e., nonstandard products or fragments, fromkamabokoprocessing factories. It is clear that the waste fromkamabokoprocessing factories is transformed effectively into fish sauce by using soy saucekojimold. As a result, the amount of the discharged wastes fromkamabokofactories are able to be minimized because the liquefaction ratio of the fish sauce mushes (moromi) from the wastes after fermentation was high and the products have a high umami taste and agreeable soy sauce‐like flavor.
Six‐minute walk distance and work relationship with incremental treadmill cardiopulmonary exercise test in COPD
Authors: Poersch Karla , Berton Danilo C. , Canterle Daversom Bordin , Castilho Juliano , Lopes André L. , Martins Jocelito , Oliveira Alvaro R. , Teixeira Paulo José Zimermann 
Published: April 2012

AbstractIntroduction:  Cardiopulmonary exercise testing (CPET) is increasingly used to evaluate the overall impact of the illness on patients with chronic obstructive pulmonary disease (COPD). While laboratory tests of exercise performance are costly, the 6‐min walk test (6‐MWT) can be more easily performed. Although the main outcome commonly used in this field test is the distance walked in 6 min (6‐MWD), this measure does not account for differences in body weight. Previous studies showed a good correlation between the work performed during the 6‐MWT with incremental cycling CPET, an exercise modality more associated with quadriceps fatigability and with lower peak oxygen consumption than incremental walking tests.Objective:  Evaluate the correlation between the 6‐MWD and its derivative body weight–walking distance product, an estimation of the work performed during the 6‐MWT, with peak from a treadmill CPET.Methods:  Thirty COPD patients [forced expiratory volume in 1 s (FEV1) =  39 ± 13%; peak predicted] performed CPET to the limit of tolerance on a treadmill and 6‐MWT, 48 h apart.6‐MWD and work were correlated to resting and exercise functional variables.Results:  The work of walking during the 6‐MWT provided greater associations with peak than observed with 6‐MWD. This was the case for FEV1, forced vital capacity, inspiratory capacity, lung diffusion capacity for carbon monoxide, peak , carbon dioxide output, minute ventilation and double product (r = 0.57, r = 0.57, r = 0.73, r = 0.7, r = 0.75, r = 0.65, r = 0.51 and r = 0.4, respectively; all P < 0.05).Conclusion:  A better association was found between the work estimated from the 6‐MWT and peak achieved during CPET, in this case with a treadmill, than the 6‐MWD alone.Please cite this paper as: Poersch K, Berton DC, Canterle DB, Castilho J, Lopes AL, Martins J, Oliveira AR and Teixeira PJZ. Six‐minute walk distance and work relationship with incremental treadmill cardiopulmonary exercise test in COPD. Clin Respir J 2013; 7: 145–152.
Comparison of blood dynamics of anticancer drugs (cisplatin, mitomycin C, epirubicin) in treatment groups of hepatic arterial infusion, hepatic arterial infusion with lipiodol and transcatheter arterial chemoembolization with lipiodol plus gelatin sponge particles in a swine model
Authors: Ikoma Akira , Kawai Nobuyuki , Sato Morio , Minamiguchi Hiroki , Nakai Motoki , Nakata Kouhei , Tanaka Takami , Sonomura Tetsuo 
Published: April 2012

Aim:  To compare the blood dynamics of anticancer drugs (cisplatin, mitomycin, epirubicin) and the negative effect on normal liver tissue among the following procedures: hepatic arterial infusion (HAI), HAI with lipiodol (Lp‐HAI) and transcatheter arterial chemoembolization (TACE) with Lp plus particles (Lp‐TACE).Methods:  Nine swine were divided into three groups: (i) HAI group animals were infused with 5 mg/mL cisplatin, 1 mg/mL mitomycin and 4 mg/mL epirubicin in 0.1 mL/kg contrast medium; (ii) Lp‐HAI group animals, with the same doses in 0.1 mL emulsified fluid (0.05 mL/kg, Lp); and (iii) Lp‐TACE group animals, with the same doses in 0.1 mL emulsified fluid plus gelatin sponge particles. Outflow ratio (area under plasma concentration curve [AUC0–60] / total infused dose of anticancer drug) and necrosis volume ratio (necrosis volume / total slice volume × 100) were explored.Results:  Outflow ratios (AUC0–60/mg) of cisplatin, mitomycin and epirubicin, and the necrosis volume ratio (%) of the livers, were 2.30, 6.91, 0.97 and 0, respectively, in the HAI group; 1.71, 5.43, 0.79 and 1.37, respectively, in the Lp‐HAI group; and 1.23, 3.37, 0.47 and 20.88, respectively, in the Lp‐TACE group. The significantly lowest outflow ratio for each anticancer drug (P = 0.05/3) and the significantly highest necrosis volume ratio (P = 0.05/3) were found in Lp‐TACE, followed by Lp‐HAI and HAI.Conclusion:  Although the necrosis volume ratio of the liver was tolerable, Lp‐TACE caused the greatest delay in outflow ratio for each cancer drug and the greatest negative effect to liver in a swine model.
Diagnostic Frequency, Response to Therapy, and Long‐Term Prognosis among Horses and Ponies with Pituitary Par Intermedia Dysfunction, 1993–2004
Authors: Rohrbach B.W. , Stafford J.R. , Clermont R.S.W. , Reed S.M. , Schott H.C. , Andrews F.M. 
Published: April 2012

BackgroundPituitary pars intermedia dysfunction (PPID) is common in older horses.ObjectivesTo determine diagnosis frequency, prognostic factors, long‐term survival, and owner satisfaction with treatment.AnimalsMedical records from horses diagnosed withPPID, 1993–2004.MethodsA retrospective cohort design with data collected from the Veterinary Medical Data Base (VMDB) and a cohort of 3VTHs. Proportional accessions, annual incidence, and demographics were compared for all accessions. During the same period, a subset of medical records (n = 44) was extracted and owners (n = 34) contacted to obtain long‐term follow‐up information.ResultsDiagnoses ofPPIDwere reported for 217 horses that presented toVTHs and were reported to theVMDB. Proportional diagnosis increased from 0.25/1,000 in 1993 to 3.72/1,000 in 2002. For 44 horses included in the follow‐up study, the most commons signs were hirsutism (84%) and laminitis (50%). Of 34 horse owners contacted, the average time from onset of signs to diagnosis was 180 days. Improvement in ≥ 1 signs, 2 months after diagnosis, was reported by 9/22 (41%) of horse owners. Clinical signs and clinicopathologic data were not associated with survival, and 50% of horses were alive 4.6 years after diagnosis. Cause of death among horses (15/20; 85%) was euthanasia, and 11/15 (73%) were euthanized because of conditions associated withPPID. Most horse owners (28/29; 97%) said they would treat a second horse forPPID.Conclusion and Clinical ImportancePPIDwas diagnosed with increasing frequency, and 50% of horses survived 4.5 years after diagnosis. Owners were satisfied with their horses' quality of life and would treat a second horse if diagnosed.
Muscle sympathetic response to arousal predicts neurovascular reactivity during mental stress
Authors: Donadio V. , Liguori R. , Elam M. , Karlsson T. , Giannoccaro M. P. , Pegenius G. , Giambattistelli F. , Wallin B. G. 
Published: April 2012

Key points
Mental stress (MS) is often initiated by a sensory or cognitive stimulus, which induces a brief arousal reaction followed by a longer stress phase. Both phases induce blood pressure (BP) increases whereas effects on muscle sympathetic nerve activity (MSNA) vary: in approximately 50% of healthy subjects (responders) arousal induces a brief MSNA reduction, which is absent in the remaining 50% (non‐responders).
We now report a link between the arousal response and neurovascular effects of MS in healthy males.
Our data show that during MS, responders to arousal exhibited a significant decrease of MSNA and a lesser BP increase compared to non‐responders. The whole material displayed a positive correlation between MSNA responses induced by arousal and MS. In addition, arousal induced MSNA changes correlated positively with BP changes during MS.
We conclude that the MSNA response to arousal predicts MSNA and BP responses to MS.
Pharmacokinetic Comparison of a Single Oral Dose of Polymorph Form I versus Form V Capsules of the Antiorthopoxvirus Compound ST-246 in Human Volunteers
Authors: Chinsangaram Jarasvech , Honeychurch Kady M. , Tyavanagimatt Shanthakumar R. , Bolken Tove' C. , Jordan Robert , Jones Kevin F. , Marbury Thomas , Lichtenstein Israel , Pickens Margaret , Corrado Michael , Landis Patrick , Clarke Jean M. , Frimm Annie M. , Hruby Dennis E. 
Published: April 2012

ABSTRACT

ST-246, a novel compound that inhibits egress of orthopoxvirus from mammalian cells, is being tested as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, crossover, exploratory study was conducted to compare the pharmacokinetics (PK) of a single daily 400-mg oral dose of ST-246 polymorph form I versus polymorph form V administered to fed, healthy human volunteers. Both forms appeared to be well tolerated, with no serious adverse events. The order of administration of the two forms had no effect on the results of the PK analyses. Form I and form V both exhibited comparable plasma concentration versus time profiles, but complete bioequivalence between the two forms was not found. Maximum drug concentration (
C
max
) met the bioequivalence criteria, as the 90% confidence interval (CI) was 80.6 to 96.9%. However, the area under the concentration-time curve from time zero to time
t
(AUC

0-
t

) and AUC
0-∞
did not meet the bioequivalence criteria (CIs of 67.8 to 91.0% and 73.9 to 104.7%, respectively). The extent of absorption of form I, as defined by AUC
0-∞
, was 11.7% lower than that of form V. Since ST-246 form I is more thermostable than form V, form I was selected for further development and use in all future studies.
Prominence of an O75 Clonal Group (Clonal Complex 14) among Non-ST131 Fluoroquinolone-Resistant Escherichia coli Causing Extraintestinal Infections in Humans and Dogs in Australia
Authors: Platell Joanne L. , Trott Darren J. , Johnson James R. , Heisig Peter , Heisig Anke , Clabots Connie R. , Johnston Brian , Cobbold Rowland N. 
Published: April 2012

ABSTRACT

Fluoroquinolone (FQ)-resistant extraintestinal pathogenic
Escherichia coli
(FQ
r
ExPEC) strains from phylogenetic group B2 are undergoing epidemic spread. Isolates belonging to phylogenetic group B2 are generally more virulent than other
E. coli
isolates; therefore, resistance to FQs among group B2 isolates is concerning. Although clonal expansion of sequence type 131 (ST131) is a major factor, the contribution of additional clonal groups has not been quantified. Group B2 FQ
r
ExPEC isolates from humans (
n
= 250) and dogs (
n
= 12) in Australia were screened for ST131, a recently recognized and rapidly emerging multidrug-resistant and virulent clonal group that is important in both human and companion animal medicine. Non-ST131 isolates underwent virulence genotyping, PCR-based O typing, partial multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), and FQ resistance mechanism analysis. Of 49 non-ST131 isolates (45 human, 4 canine), 49% (24 human, 2 canine) represented O-type O75 and exhibited conserved virulence genotypes (F10
papA
allele,
iha
,
fimH
,
sat
,
vat
,
fyuA
,
iutA
,
kpsM
II,
usp
,
ompT
,
malX
, K1/K5 capsule) and MLST allele profiles corresponding with clonal complex CC14. Two clusters, each containing canine and human isolates, were identified by PFGE (differentiated by K1 and K5 capsules). Australian FQ
r
O75 isolates exhibited commonality with an historical FQ-susceptible O75 urosepsis isolate (also CC14). The isolation from humans and dogs of highly similar FQ
r
derivatives of the classic O75:K1/K5 (CC14) ExPEC lineage suggests recent acquisition of FQ resistance and potential cross-host-species transfer. This lineage should be targeted with ST131 in future epidemiological investigations of FQ
r
ExPEC.