bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for NSF: A literature review
Authors: Prince Martin R. , Zhang Hong Lei , Roditi Giles H. , Leiner Tim , Kucharczyk Walter 
Published: November 2009

AbstractEmerging evidence linking gadolinium‐based contrast agents (GBCAs) to nephrogenic systemic fibrosis (NSF) has changed medical practice patterns toward forgoing GBCA‐enhanced magnetic resonance imaging (MRI) or substituting other imaging methods, which are potentially less accurate and often radiation‐based. This shift has been based on reports of high NSF incidence at sites where a confluence of risk factors occurred in patients with severe renal dysfunction. This review article explores the factors that affect NSF risk, compares risks of alternative imaging procedures, and demonstrates how risk can be managed by careful selection of GBCA dose, timing of injection with respect to dialysis, and other factors. Nearly half of NSF cases are a milder form that does not cause contractures or reduce mobility. It appears that eliminating even a single risk factor can reduce NSF incidence/risk at least 10‐fold. Elimination of multiple risk factors by using single‐dose GBCA, dialyzing dialysis patients quickly following GBCA administration, avoiding GBCA in acute renal failure while serum creatinine is rising, and avoiding nonionic linear GBCA in renal failure patients may reduce NSF risk more than a thousand‐fold, thereby allowing safe GBCA‐enhanced MRI in virtually all patients. J. Magn. Reson. Imaging 2009;30:1298–1308. © 2009 Wiley‐Liss, Inc.
Guideline to use gadolinium‐based contrast agents at Kyoto University Hospital
Authors: Miki Yukio , Isoda Hiroyoshi , Togashi Kaori 
Published: November 2009

AbstractGuideline to use gadolinium‐based contrast agents (GBCAs) to prevent nephrogenic systemic fibrosis (NSF) at Kyoto University Hospital is presented. This guideline is basically the same as the one issued by the joint committee of the Japan Radiological Society and Japanese Society of Nephrology. In the guideline of the joint committee of Japan Radiological Society and Japanese Society of Nephrology, it is described that GBCAs should be used only when they are indispensable for adequate diagnosis regardless of renal function. In this guideline, it is also described that use of GBCAs should be decided after carefully weighing the risks and benefits for patients with estimated glomerular filtration rate (eGFR) 30–60 mL/min/1.73 m2, and that use of the smallest possible amount of GBCA is necessary even for patients whose eGFR is greater than 60 mL/min/1.73 m2. The guideline of Kyoto University Hospital includes regulations for patients who underwent or are waiting for liver transplantations, because patients with liver transplantations are reported to have higher risk for NSF and because several hepatic transplantation surgeries are performed at our hospital. Our guideline also regulates the use for neonates or infants less than 1 year old, because of their immature renal function. J. Magn. Reson. Imaging 2009;30:1364–1365. ©2009 Wiley‐Liss, Inc.
Removal of gadolinium by dialysis: Review of different strategies and techniques
Authors: Silberzweig Jeffrey I. , Chung Miriam 
Published: November 2009

AbstractNephrogenic systemic fibrosis (NSF) has been related to the administration of gadolinium‐based contrast agents for magnetic resonance imaging studies in patients with kidney disease. After reviewing the pathophysiology of NSF, we discuss the possible factors contributing to the toxicity of gadolinium in susceptible patients, including the excessive amounts of intravenous iron and erythropoietin as well as the inflammatory states commonly seen in patients treated with hemodialysis. Since free gadolinium is the most accepted risk factor for NSF, we provide some suggestions to improve clearance of both free and chelated gadolinium using different dialysis strategies and techniques. J. Magn. Reson. Imaging 2009;30:1347–1349. © 2009 Wiley‐Liss, Inc.
A comprehensive study of classification methods for medical diagnosis
Authors: Bocklitz Thomas , Putsche Melanie , Stüber Carsten , Käs Josef , Niendorf Axel , Rösch Petra , Popp Jürgen 
Published: November 2009

AbstractIn this model study, we developed a method to distinguish between breast cancer cells and normal epithelial cells, which is in principal suitable for online diagnosis by Raman spectroscopy. Two cell lines were chosen as model systems for cancer and normal tissue. Both cell lines consist of epithelial cells, but the cells of the MCF‐7 series are carcinogenic, where the MCF‐10A cells are normal growing. An algorithm is presented for distinguishing cells of the MCF‐7 and MCF‐10A cell lines, which has an accuracy rate of above 99%. For this purpose, two classification steps are utilized. The first step, the so‐called top‐level classifier searches for Raman spectra, which are measured in the nuclei region. In the second step, a wide range of discriminant models are possible and these models are compared. The classification rates are always estimated using a cross‐validation and a holdout‐validation procedure to ensure the ability of the routine diagnosis to work in clinical environments. Copyright © 2009 John Wiley & Sons, Ltd.
Conformational landscape of small organosilicon compounds from the combined use of gas electron diffraction, IR and Raman spectroscopies and quantum chemical calculations: diethyldichlorosilane
Authors: Montejo Manuel , Wann Derek A. , Rodríguez Ortega Pilar G. , Robertson Heather E. , Márquez Fernando , Rankin David W. H. , López González Juan Jesús 
Published: November 2009

AbstractA conformational study of diethyldichlorosilane and the elucidation of the gas‐phase molecular structures of its four conformers have been performed using the combined approach of gas‐phase electron diffraction and computational techniques. Moreover, the Raman spectrum of the liquid and the IR spectra of the gas and liquid phases have been recorded and thoroughly analyzed on the basis of the scaled quantum‐mechanical force field methodology. The results of the vibrational assignment have given spectroscopic evidence of the presence of the different conformers in the samples. Copyright © 2009 John Wiley & Sons, Ltd.
Enhancing antioxidant availability in wheat grains from plants grown under seawater stress in response to microalgae extract treatments
Authors: Abd El‐Baky Hanna H , El‐Baz Farouk K , El Baroty Gamal S 
Published: November 2009

AbstractBACKGROUND: The present study was designed to investigate the enhanced antioxidant capacity of whole grains from wheat plants grown under seawater stress in response to microalgae extract treatment.RESULTS: The total carotenoid (TCAR), tocopherol (TOC), phenolic (TPC), and protein (PC) contents in whole grains of wheat plants irrigated with 10% and 20% (v/v) seawater (SW) in response to water extracts of microalgae Spirulina maxima (SME) and Chlorella ellipsoida (CEE) as well as exogenous plant growth enhancers of ascorbic acid and benzyladenine treatments were measured. The results showed that the levels of enhanced TCAR (range 0.08–0.14 g kg−1), TOC (range 0.05–0.12 g kg−1), TPC (range 0.80–2.96 g kg−1) and PC (range 93.4–137.9 g kg−1) in wheat grains of plants irrigated with 10% and 20% SW were significantly increased in response to SME and CEE treatments. Evaluation of antioxidant activity of ethanolic extracts of grains of SW‐stressed plants indicated that DPPH and TBAS radical scavenging activity was significantly increased in response to SME and CEE treatments and coincided with the increase in levels of antioxidant compounds present in each extract. The electrophoretic profiles of the grains of proteins of treated samples exhibited quite different patterns from those in control samples.CONCLUSION: The results suggest that the application of algal extracts to wheat plants irrigated with SW is useful for improvement of salinity tolerance. This effect can be triggered by the stimulation of antioxidant components and protein content. Copyright © 2009 Society of Chemical Industry
Effect of grass–clover forage and whole‐wheat feeding on the sensory quality of eggs
Authors: Horsted Klaus , Hammershøj Marianne , Allesen‐Holm Bodil H 
Published: November 2009

AbstractBACKGROUND: A sensory panel evaluated the sensory profile of eggs from hens from three experimental systems: (1) an indoor system × normal layer diet (InL), (2) a grass–clover forage system × normal layer diet (GrL), and (3) a grass–clover forage system × whole wheat and oyster shells (GrW).RESULTS: The taste of the albumen was significantly more ‘watery’ and the yolks a darker yellow/orange in the eggs from the GrL and GrW groups. The yolk was darkest from the GrW group. The yolks from the InL and GrW groups had a significantly more ‘fresh’, less ‘animal’, ‘cardboard’, and ‘intense’ aroma than the GrL group. The taste of the yolks from the InL and GrW groups was significantly more ‘fresh’ and less ‘cardboard’‐like compared to the GrL group. The yolks tasted significantly less ‘sulfurous’ in the GrW group than in the GrL group.CONCLUSION: The combination of a high feed intake from a grass–clover pasture and the type of feed allocated is an important factor in relation to the sensory quality of eggs. Thus, a less favourable sensory profile of eggs was found from hens on a grass–clover pasture and fed a normal layer diet. Copyright © 2009 Society of Chemical Industry
Excision of axillary lymph node recurrences in breast cancer patients with axillary ROLL (A‐ROLL)
Authors: Aydogan Fatİh , Ozben Volkan , Atasoy Denİz , Yilmaz Mehmet Halİt , Halaç Metİn , Çelİk Varol 
Published: November 2009

AbstractBackground and ObjectivesConventional surgical exploration to find clinically occult axillary lymph node recurrence of breast cancer can be challenging. The aim of this study was to determine the place of our alternative technique, axillary‐ROLL (A‐ROLL), in previously treated breast cancer patients with nonpalpable axillary lymph node recurrences.MethodsBetween March 2005 and May 2009, included in this retrospective study were four women (age, 42–51 years) without clinical evidence of distant metastasis who had treatment for breast cancer and were subsequently found to have suspicious axillary lymph node(s) detected by control ultrasonography (US) examination during follow‐up. A‐ROLL was utilized for the identification of lymph nodes. 0.5–1 mCi 99mTc‐human serum albumin makroaggregate was injected under US guidance. A gamma probe was then used to guide the excision of the lymph nodes.ResultsThe involved lymph nodes were successfully localized by A‐ROLL technique and removed surgically. Of all four patients, postoperative histopathologic examination revealed nodal cancer metastases in three patients (75%) and lymphoid hyperplasia in one patient. No complications occurred.ConclusionsA‐ROLL technique has proved to be accurate and safe in the identification and excision of clinically occult axillary lymph node recurrence. J. Surg. Oncol. 2010;101:141–144. © 2009 Wiley‐Liss, Inc.
Preoperative tumor marker doubling time is a useful predictor of recurrence and prognosis after hepatic resection of hepatocellular carcinoma
Authors: Masuda Toshiro , Beppu Toru , Horino Kei , Komori Hiroyuki , Hayashi Hiromitsu , Okabe Hirohisa , Otao Ryu , Horlad Hasita , Ishiko Takatoshi , Takamori Hiroshi , Kikuchi Ken , Baba Hideo 
Published: November 2009

AbstractBackground and ObjectivesIt is important to identify prognostic factors in patients with hepatocellular carcinoma (HCC) before hepatectomy. No previous studies have addressed the predictive efficacy of the preoperative doubling times of alpha‐fetoprotein (AFP) and protein induced by vitamin K absence (PIVKA‐II).MethodsA total of 210 HCC patients who underwent a hepatic resection between 1998 and 2006 were prospectively evaluated. Serum AFP and PIVKA‐II levels were measured at least twice before surgery to calculate the doubling times. Nineteen clinical factors that can be examined preoperatively, including the doubling times of AFP and PIVKA‐II were investigated to identify prognostic factors for disease‐free and overall survival after hepatectomy.ResultsThere was no relationship between preoperative levels and doubling times of AFP and PIVKA‐II. In a multivariate analysis, patients with a doubling time of AFP ≤30 days and PIVKA‐II ≤16 days showed a significantly worse disease‐free (P = 0.02, P = 0.03, respectively) and overall survival (P < 0.0001, P = 0.03, respectively).ConclusionsIn HCC patients, the doubling times of preoperative serum AFP or PIVKA‐II levels are useful tools to predict early postoperative recurrence and a poor prognosis. J. Surg. Oncol. 2010;102:490–496. © 2009 Wiley‐Liss, Inc.
Simultaneous determination of five tetracycline and macrolide antibiotics in feeds using HPCE
Authors: Tong Jing , Rao Qinxiong , Zhu Kui , Jiang Zhigang , Ding Shuangyang 
Published: November 2009

AbstractThis work demonstrates the potential of HPCE in the analysis of antibiotics in a complex matrix such as feedstuffs. Using 20 mM citric acid–40 mM Na2HPO4 buffer (pH 2.65), the five antibiotics, tetracycline, oxytetracycline, doxycycline, tilmicosin, and tylosin were successfully separated at 30 kV in a 64.5 cm×75 μm id capillary. Good repeatability, stability, and reliability of the method were supported by <10% CV with mean recoveries of >70%, and the limit of detection of the five analytes was 0.5–1 mg/kg. It was for the first time that a capillary electrophoretic method was employed to simultaneously detect five tetracycline and macrolide antibiotics in animal feeds.
Switchable Wettability of Thermo‐Responsive Biocompatible Nanofibrous Films Created by Electrospinning
Authors: Gu Shu‐Ying , Wang Zhi‐Mei , Li Jian‐Bo , Ren Jie 
Published: November 2009

AbstractThermo‐responsive PNIPAAm/PLLA nanofibrous films with tunable surface morphologies and better biocompatibility were prepared by electrospinning technique. The electrospun composite films possessed a “bead‐on‐string” structure. The wettability of nanofibrous films was observed by water CA measurements. The results showed that the electrospinning process and addition of PLLA did not change the thermo‐sensitivity of PNIPAAm. The wettability of electrospun PNIPAAm/PLLA composite films could switch from superhydrophilic to superhydrophobic when the temperature increased from 20 to 50 °C. Electrospinning is a promising way to create stimuli‐responsive surfaces with potential application in the design and tactics of controllable drug delivery system.magnified image
Psychometric properties of the SCOPA‐AUT Brazilian Portuguese version
Authors: Carod‐Artal Francisco Javier , da Silveira Ribeiro Luciola , Kummer Wladimir , Martinez‐Martin Pablo 
Published: November 2009

AbstractCross‐cultural adaptation and psychometric assessment of the Scales for Outcomes in Parkinson's Disease‐Autonomic questionnaire (SCOPA‐AUT) Brazilian Portuguese version. 150 consecutive Parkinson's disease (PD) patients were evaluated by means of the SCOPA‐motor scale (SCOPA‐M), SCOPA‐cognition (SCOPA‐COG), Hoehn and Yahr staging (H&Y), nonmotor symptoms scale (NMSS), PD questionnaire (PDQ‐39), and SCOPA‐AUT. The following psychometric attributes were explored: acceptability, scaling assumptions, reliability, precision, and construct validity. Patients' age (mean ± standard deviation) was 63.1 ± 11.1 years (56.7% men; duration of disease, 8.7 ± 5.3 years; median H&Y, 2). Mean SCOPA‐AUT was 23.0 ± 11.2. SCOPA‐AUT did not show floor or ceiling effect. As a whole, the SCOPA‐AUT item‐domain correlation was satisfactory, except for items 2 (Saliva), 7 (Faecal incontinence), 16 (Syncope), and 19 (Cold intolerance) (|rS| = 0.03–0.32). Internal consistency was adequate, except for thermoregulatory and cardiovascular domains (alpha coefficients, 0.56 and 0.63, respectively). Intraclass correlation coefficient for the total score was 0.71, whereas weighted kappa for individual items ranged from 0.15 to 0.71 (only items 4 and 7 were <0.40). Standard error of measurement was 6.04. The SCOPA‐AUT total score correlated closely with the NMSS total score (rS = 0.65) and PDQ‐39 Summary Index (rS = 0.61) and at a moderate level with H&Y staging (rS = 0.35) and SCOPA‐MS total score (rS = 0.39) (all rS values, P < 0.0001). Correlation of SCOPA‐AUT with SCOPA‐COG was weak. SCOPA‐AUT significantly increased as the H&Y stage increased (Kruskal‐Wallis, P < 0.0001). The SCOPA‐AUT Brazilian Portuguese version is an acceptable, reliable, and valid questionnaire to evaluate autonomic dysfunction in PD. © 2009 Movement Disorder Society
A positive influence of vision on motor symptoms during sensory attention focused exercise for Parkinson's disease
Authors: Sage Michael D. , Almeida Quincy J. 
Published: November 2009

AbstractThis study evaluated the effect of increased attention to sensory feedback during exercise. Two 12‐week exercise programs that differed only in the presence (PD SAFEx™) or absence (non‐SAFE control group) of increased attention focused on sensory feedback were compared. Participants were assessed symptomatically using the Unified Parkinson's Disease Rating Scale (UPDRS) before the start of the exercise program, immediately following the 12‐week program and after a 6‐week nonexercise washout period. Secondary outcome measures included the Timed‐Up‐and‐Go (TUG), Grooved Pegboard (GP) and velocity and step length of self‐paced gait. Both groups significantly improved on the TUG, GP, velocity, and step length, and this was maintained after a 6‐week washout period. Of additional interest, only the PD SAFEx™ program significantly improved motor symptoms (UPDRS). These gains were maintained in the PD SAFEx™ group 6 weeks after the exercise was stopped, while motor symptoms significantly worsened in the non‐SAFE group. These results suggest that increasing awareness of sensory feedback may be a critical factor that specifically impacts motor symptoms. Future work should strive to uncover the underlying neurophysiological mechanism behind this effect. © 2009 Movement Disorder Society
Comparing endophenotypes in adult‐onset primary torsion dystonia
Authors: Bradley David , Whelan Robert , Walsh Richard , O'Dwyer John , Reilly Richard , Hutchinson Siobhan , Molloy Fiona , Hutchinson Michael 
Published: November 2009

AbstractAdult‐onset primary torsion dystonia (AOPTD) has an autosomal dominant pattern of inheritance with markedly reduced penetrance; the genetic causes of most forms of AOPTD remain unknown. Endophenotypes, markers of sub‐clinical gene carriage, may be of use detecting non‐manifesting gene carriers in relatives of AOPTD patients. The aim of this study was to compare the utility of the spatial discrimination threshold (SDT) and temporal discrimination threshold (TDT) as potential endophenotypes in AOPTD. Data on other published candidate endophenotypes are also considered. Both SDT and TDT testing were performed in 24 AOPTD patients and 34 of their unaffected first degree relatives; results were compared with normal values from a control population. Of the 24 AOPTD patients 5 (21%) had abnormal SDTs and 20 (83%) had abnormal TDTs. Of the 34 first degree relatives 17 (50%) had abnormal SDTs and 14 (41%) had abnormal TDTs. Discordant results on SDT and TDT testing were found in 16 (67%) AOPTD patients and 21 (62%) first degree relatives. TDT testing has superior sensitivity compared to SDT testing in AOPTD patients; although false positive TDTs are recognised, the specificity of TDT testing in unaffected relatives is not determinable. The high level of discordance between the two tests probably relates methodological difficulties with SDT testing. The SDT is an unreliable AOPTD endophenotype; TDT testing fulfils criteria for a reliable endophenotype with a high sensitivity. © 2009 Movement Disorder Society
Lunasin, with an arginine–glycine–aspartic acid motif, causes apoptosis to L1210 leukemia cells by activation of caspase‐3
Authors: Gonzalez de Mejia Elvira , Wang Wenyi , Dia Vermont P. 
Published: November 2009

AbstractLunasin is a novel chemopreventive peptide featuring a cell adhesion motif composed of arginine–glycine–aspartate (RGD) which has been associated to cytotoxicity to established cell lines. The objectives of this study were to determine the effect of lunasin on the viability of L1210 leukemia cells and to understand the underlying mechanisms involved. Pure lunasin and lunasin enriched soy flour (LES) caused cytotoxicity to L1210 leukemia cells with IC50 of 14 and 16 μM (lunasin equivalent), respectively. Simulated gastrointestinal digestion showed that 25% of the original amount of lunasin survived 3 h of pepsin digestion and 3% of lunasin remained after sequential pepsin–pancreatin digestion for a total of 6 h. Cell cycle analysis showed that lunasin caused a dose‐dependent G2 cell cycle arrest and apoptosis. Treatment of L1210 leukemia cells with 1 mg/mL of LES for 18 h led to an increase in the amount of apoptotic cells from 2 to 40%. Compared to untreated cells, treatment with 1 mg/mL LES showed a 6‐fold increase on the expressions of caspases‐8 and ‐9, and and a 12‐fold increase on the expression of caspase‐3. These results showed for the first time that lunasin, a naturally occurring peptide containing an RGD motif, caused apoptosis to L1210 leukemia cells through caspase‐3 activation.
PPARα L162V polymorphism alters the potential of n‐3 fatty acids to increase lipoprotein lipase activity
Authors: Rudkowska Iwona , Caron‐Dorval Dominique , Verreault Mélanie , Couture Patrick , Deshaies Yves , Barbier Olivier , Vohl Marie‐Claude 
Published: November 2009

AbstractOmega‐3 fatty acids (FAs) may accelerate plasma triglyceride (TG) clearance by altering lipoprotein lipase (LPL) activity. Yet, the ability of n‐3 FAs to increase LPL activity is dependent on transcription factors such as peroxisome proliferator‐activated receptor alpha (PPARα). The objective was to examine the effects of n‐3 FAs on LPL activity considering the occurrence of PPARα L162V polymorphism. First, 14 pairs of men either L162 homozygotes or carriers of the V162 allele were supplemented with n‐3 FAs. Second, transient transfections in HepG2 cells, for the L162‐ and V162‐PPARα variants with the peroxisome proliferator‐response element from the human LPL gene, were transactivated with n‐3 FAs. In vivo results demonstrate that the LPL activity increased non‐significantly by 14.4% in L162 homozygotes compared with 6.6% in carriers of the PPARα‐V162 allele, after n‐3 FA supplementation. Additionally, the L162 homozygotes tended towards an inverse correlation between LPL activities and plasma TG levels. Conversely, carriers of the V162 allele showed no such relationship. In vitro data demonstrates that transcription rates of LPL tended to be higher for the L162‐PPARα than V162‐PPARα after n‐3 FAs activation. Overall, these results indicate that n‐3 FA supplementation increases the transcription rate of LPL to a greater extent in L162‐PPARα than V162‐PPARα.