bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correction of Nitrosative Stress During Reparative Regeneration of the Nasal Cavity Mucosa in an Experimental
Authors: Berest I. Ye. 
Published: May 2024

Introduction. Nitric oxide metabolites play an important role in prolongation of the inﬂammatory reaction, disorders of epithelial regeneration in diseases of the upper respiratory tract. One of the promising approaches to regulating the bioactivity of nitric oxide is the use of antioxidants.The objective of the study is to evaluate the eﬀectiveness of antioxidant therapy for the correction of nitrosative stress during reparative regeneration of the nasal mucosa in an experiment.Methods. A preclinical randomized experimental study is conducted on 160 rats, divided into 4 groups. The control group (n = 40) consists of intact animals. Animals in experimental group 1 (n = 40) do not receive treatment aﬅer injury; in group 2 (n = 40) anti-inﬂammatory treatment is prescribed. The third group consists of laboratory rats (n = 40), which are additionally injected into the nasal cavity with an antioxidant — a 15 % solution of 1,1-dimethyl-3-oxobutylphosphonic acid dimethyl ester. On days 2, 5, 10, and 14 of observation, the concentration of nitrates and nitrites and C-reactive protein in the blood of animals are determined.Results. In group 3, aﬅer an increase in the level of nitric oxide metabolites on day 2 aﬅer injury on day 5, a signiﬁcant (p < 0.05) decrease was noted in comparison with other groups, and by day 10— normalization of the indicator. An increase in the level of C-reactive protein in blood serum correlated with the concentration of nitric oxide metabolites.Discussion. The optimal therapeutic eﬀect when taking antioxidants develops when administered in the ﬁrst hours aﬅer injury to reduce the excessive formation of reactive nitrogen radicals. However, the duration of administration should not exceed 4–5 days to avoid a signiﬁcant decrease in the level of nitric oxide metabolites and deterioration of mucosal regeneration.Conclusions. Assessment of nitric oxide metabolitesin the blood at diﬀerent times aﬅer injury is an important marker of inﬂammatory activity. The use of antioxidants helps to reduce the concentration of active nitrogen radicals.
Penanganan Konflik dalam Hubungan Pernikahan sebagai Bentuk Pelayanan Pastoral bagi Keluarga Kristen
Authors: Franky Franky 
Published: May 2024

Conflict in marriage is inevitable and misunderstandings are a natural part of marriage. On the one hand, conflict in a marriage relationship can be destructive, creating resentment and distrust, disconnection, or violent confrontation. But, on the other hand, conflict can also be positive, opening up issues for analysis, clarification and improved problem-solving, encouraging spontaneous and open communication so that the relationship between one party and the other can grow for the better. In relation to conflict. Based on the existing problems, specifically related to conflict in marital relationships that have a destructive impact, it is necessary to understand based on a Christian perspective on handling conflict in marital relationships based on the standards of God's Word as a form of pastoral service for every Christian family. To achieve the research objectives described above, the method used is a qualitative method with a descriptive approach through literature study. Through the method used, the results found that the handling of conflict in marital relationships in Christian families are first, the biblical view of the Christian family that must be understood as a preventive step towards conflict in marital relationships; second, pastoral assistance services for conflicted married couples and third, forgiveness as a solution in resolving conflict in marital relationships.Konflik di dalam pernikahan tidak dapat dihindari dan kesalahpahaman adalah suatu bagian yang alami dalam pernikahan. Di satu sisi, konflik dalam hubungan pernikahan dapat berakibat merusak, menciptakan rasa benci dan tidak percaya, pemutusan hubungan, atau konfrontasi dengan kekerasan. Tapi, di sisi yang lain, konflik juga dapat berakibat positif, dengan membuka permasalahan agar dapat dianalisa, diperjelas dan memperbaiki pemecahan masalah, mendorong komunikasi yang spontan dan terbuka sehingga hubungan antara satu pihak dan yang lainnya dapat tumbuh menjadi lebih baik. Berkaitan dengan konflik. Berdasarkan permasalahan yang ada, secara khusus berkaitan dengan konflik dalam hubungan pernikahan yang berdampak destruktif, maka dibutuhkan pemahaman berdasarkan perspektif Kristen tentang penanganan konflik dalam hubungan pernikahan berdasar standar Firman Tuhan sebagai bentuk pelayanan pastoral bagi setiap keluarga Kristen. metode yang digunakan Untuk mencapai tujuan penelitian yang telah dipaparkan diatas adalah metode kualitatif dengan pendekatan deskriptif melalui studi literatur. Melalui metode yang digunakan, maka hasil yang ditemukan bahwa Penanganan Konflik dalam hubungan Pernikahan dalam keluarga Kristen adalah pertama, Pandangan Alkitab mengenai Keluarga Kristen yang harus dipahami sebagai Langkah Preventif terhadap Konflik dalam Hubungan Pernikahan; kedua, Pelayanan Pendampingan Pastoral bagi Pasangan Suami Isteri yang Berkonflik dan ketiga, Pengampunan Sebagai Solusi dalam Penyelesaian Konflik dalam Hubungan Pernikahan.
Phytochemistry, Invitro Anti-Trypanosomal Efficacy and Acute Toxicity of ‎Allium sativum Linn. Bulb Aqueous Extract
Authors: Biu A. A. , Buratai L. B. , Maina U. A. , Yunus Y. S. , Aliyu U. , Kutigi A. A. 
Published: May 2024

Allium sativum Linn. is a bulbos perennial plant of the Family Liliaceae has been reported as having potential medicinal properties. This study was on the phytochemistry, in vitro anti-trypanosomal efficacy and acute toxicity of Allium sativum Linn bulb aqueous extract using standard procedures. Qualitative phytochemistry indicated high scores (+++) for reducing sugars, moderate scores (++) for alkaloids, steriods and carbohydrates with low scores (+) for tannins, flavonoids and saponins. The median lethal dose of the aqueous extract in albino rats was determined to be 2400 mg/kg body weight following intraperitoneal administration. The albino rats exhibited weakness, lordosis, starry hair coat, awkward posture, loss of apetite. All the albino rats died within 24 hours. There was a significant (p<0.05) reduction in mean parasites count (x106) on exposure in vitro to all the graded extract concentrations compared with the normal, and parasite count also decreasedwith time post-inoculation. Similarly, a positive correlation existed between extract concentrations and inhibition rates of the parasites post-inoculation. In conclusion, the aqueous extract of Allium sativum has in vitro anti-trypanosomal activity.
Sonographic changes during Postpartum Uterine Involution in Sahel Goats (Capra hircus)
Authors: Majama Y. B. , Zakariah M. , Sanda K. A. , Asuku S. O. , Bukar M. M. , Kwari H. D. 
Published: May 2024

The use of ultrasonography as diagnostic tool is crucial in animal reproduction especially in pregnancy diagnosis and can be useful in the assessment of postpartum uterine involution. Uterine involution in does has been described using macroscopic and histological examination post-mortem. The present study was carried out to determine the time of uterine involution in live Sahel goats by measuring the uterine diameter using ultrasonography. A total of 35 non-pregnant does were estrus synchronized using 2 intramuscular injection cloprostenol (250µg/kg) at 11 days interval. All the does that came into estrus after the second treatment were allowed to run free with five bucks. Pregnancy was determined by ultrasonography and the does were monitored until successful parturition. It was found that the diameter of the uterus decreased from 88.6-118 mm on day 1 postpartum to 80.8-88.6 mm, 55.3-80.8, 45.6-55.3, 39.0-45.6 mm and 24.0-39.0 mm diameters on days 3, 7, 14, 21 and 28 postpartum respectively. In conclusion, postpartum uterine involution in Sahel does was completed by day 28 postpartum. This finding suggests that breeding of Sahel does can be considered after 28 days postpartum, particularly, in circumstances where suckling of the kids is not practicable or desired.
Antibiofilm Potential of Aqueous Extracts of Garcinia kola against ‎Salmonella species in Greater Cane Rat (Thryonomys swinderianus, ‎Temmink 1827) from Badagry, Lagos State, Nigeria
Authors: Orum T. G. , Gilbert T. T. , Omirinde J. O. , Okunlade O. A. , Okoronkwo O. M. , Yilave B. M. , Edward I. G. , Omile I. C. 
Published: May 2024

Biofilms encompass a cluster of microorganisms encased in a slimy matrix of extracellular polymeric substances, which imbibe antibiotic resistance. Salmonella specie is a major bacterial cause of food-borne diseases in both humans and animals. The prevalence of Salmonella species is increasing which may form biofilm, and bacteria that form biofilm may be more resistant to antimicrobial agents. This study is intended to determine the presence and antimicrobial susceptibility patterns of Salmonella species among greater cane rats and carry out the biofilm formation of isolated Salmonella species and dispersion using Garcinia kola. A total of 20 cane rats were obtained from a farm in Lagos state and roadside hunters. Samples of rectal swabs were collected aseptically for bacterial culture. Bacteria isolation was done with selective media using standard bacteriological techniques following pre-enrichment of the samples with buffered peptone water. Gram staining and biochemical tests were used for confirmation of the organisms. An antimicrobial susceptibility test was performed following standard protocol. Zones of inhibition were measured and categorized as totally sensitive and resistant. Nine (9) isolates of Salmonella species were obtained from rectal swabs of greater cane rats. A modified crystal violet assay was employed to develop biofilm and test the effect of a crude extract of Garcinia kola on biofilm dispersal. Data obtained from this study was subjected to statistical analysis using descriptive statistics and paired t-test at a level of significance of P ≤ 0.05. The overall prevalence of Salmonella species obtained in this study was 45%. Antimicrobial study showed susceptibility of 77.8% for Chloramphenicol and 66.7% for Cefuroxime while all isolates were 100% susceptible to Amikacin and Gentamicin. The effect of Garcinia kola extract on different isolates at 430nm showed a significant difference (p= 0.0348) in biofilm formation in isolates with Garcinia kola extract when compared with isolates without extract. The effect of Garcinia kola extract on different isolates at 650nm elicited significant (p = 0.0216) biofilm inhibitions across the isolates. The antibiofilm activity displayed by Garcinia kola suggests its potential to serve as an alternative antimicrobial agent to combat drug resistant bacteria such as Salmonella species. However, further investigations should be carried out on the individual bioactive compounds to know the exact metabolites responsible for the antibiofilm activity of this bacteria species.
IN STENT RESTENOSIS (ISR) IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION (PCI) FOR CORONARY ARTERY DISEASE (CAD)
Authors: ULLAH S , ARSHAD MH , HUSSAIN J 
Published: May 2024

In-stent restenosis (ISR) remains a significant clinical challenge in patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease (CAD). Objectives: The main aim of the study is to find the In-Stent Restenosis (ISR) in patients undergoing percutaneous coronary intervention (PCI) for coronary artery disease (CAD). Methods: This cross-sectional study was conducted at Prime Teaching Hospital Peshawar from January 2023 till December 2023. Data were collected from 80 patients from both genders. Patients who underwent PCI for CAD and developed ISR, as confirmed by angiographic or intravascular imaging studies, were included. Data were collected in a systematically designed performance. Information was collected from electronic medical records, angiographic reports, and procedural databases. Results: Data were collected from 80 patients according to inclusion criteria. The mean age of the patients was 65.09±8.5 years. There were 52 (65%) male and 48 (35%) female patients. Hypertension was present in 60 (75%), dyslipidemia in 48(60%) and DM in 36 (45%) patients. There was a significant association between older age and increased likelihood of ISR development post-PCI (Mean age ISR: 68.01 ± 7.2 years vs. No ISR: 62.39 ± 9.1 years, p=0.02). However, gender did not significantly influence ISR occurrence (71% male ISR vs. 62% male No ISR, p=0.42). Conclusion: It is concluded that ISR represents a significant challenge in patients post-PCI for CAD, with a substantial incidence observed in this study. Older age, diabetes mellitus, and DES implantation were identified as essential contributors to ISR development.
Psychological immunity and its relationship to the orientation towards competition among the female players of the University of Kufa futsal team
Authors: Ali Muhammad Jawad Al-Sayegh  , Mohsen Mohamed Hassan  , Israa Allawi Hassan  
Published: May 2024

ﻧﺘﻴﺠﺔ وجود ﻋﻼﻗﺔ ﻣﺒﻬﻤﺔ ﺍﻭ ﻏﻴﺮ ﻭﺍﺿﺤﺔ ﺑﻴﻦ التوجه التنافسي والمناعة النفسية و الكشف ﻋﻦ ﻣﺜﻞ هذه ﺍﻟﺴﻤﺔ عند لاعبات منتخب جامعة الكوفة بكرة قدم الصالات ﻋﻠﻴﻪ وجد ﺍﻟﺒﺎﺣﺜون ﺍﻥ هذه المشكلة جديرة بالدراسة و هدف البحث الى التعرف على مستوى المناعة النفسية والتوجه نحو المنافسة لدى لاعبات منتخب جامعة الكوفة بكرة قدم الصالات والتعرف على العلاقة بين المناعة النفسية والتوجه نحو المنافسة لدى لاعبات منتخب جامعة الكوفة بكرة قدم الصالات و استخدم الباحثون المنهج الوصفي بالاسلوب ﺍﻟﻤﺴﺤﻲ ﻭﺍﻟﻌﻼﻗﺎﺕ ﺍﻻﺭﺗﺒﺎﻁﻴﺔ لملائمتها لطبيعة المشكلة اما عينة البحث فقد تكونت من لاعبات جامعة الكوفة بكرة قدم الصالات والبالغ عددهن (14) لاعبة للعام الدراسي ( 2023-2024) وقد تـم جمع البيانات باستخدام مقياسي المناعة النفسية والتوجه نحو المنافسة وتـمت معالجة البيانات التي حصل عليها الباحثون باستخدام (النسبة المئوية, الوسط الحسابي,الانحراف المعياري, قانون المتوسط الفرضي, اختبارت لعينة واحدة,معامل الارتباط البسيط) و تم استخدام مقياس المناعة النفسية والمکون من (39) فقرة قائمة التوجه التنافسي لقياس التوجه التنافسي للاعب الرياضي من حيث أنه أحد الأبعاد الهامة لتوجهات هدف الإنجاز الرياضي. واستنتج الباحثون عن وجود علاقة ارتباط معنوية بين المناعة النفسية والتوجه نحو المنافسة لدى لاعبات منتخب جامعة الكوفة بكرة قدم الصالات العلاقة بين التوجه التنافسي والمناعة النفسية علاقة طردية لاعبات منتخب جامعة الكوفة بكرة قدم الصالات يتمتعون بمستوى جيد من المناعة النفسية والتوجه التنافسي والهدف الاساسي لخلق تنمية البحث المستديمة هو العمل على الارتقاء بتحسين الجوانب النفسية والذهنية للعمل بها والارتقاء بفعالية كرة قدم الصالات وهذا ما يحقق احد اهداف التنمية المستدامة للامم المتحدة في العراق (التعليم الجيد)
ENDOTHELIN-1 AS A PROGNOSTIC MARKER FOR THE DEVELOPMENT OF SOCIALLY SIGNIFICANT DISEASES IN PEDIATRICS (LITERATURE REVIEW)
Authors: Пономаренко Е.А. , Хомякова Т.И. , Мхитаров В.А. , Хомяков Ю.Н. 
Published: May 2024

Поиск специфических прогностических и диагностических маркеров – актуальная задача современной педиатрии. Эндотелий – активная система, которая функционирует как рецепторно-эффекторный орган, реагирующий на экзогенный или эндогенный стимул с выделением разнообразных молекул, призванных восстановить сосудисто-тканевый гомеостаз. Эндотелий, с одной стороны, участвует практически во всех процессах, определяемых как гомеостаз, гемостаз и воспаление, с другой – это первое звено патогенеза различных заболеваний как у взрослых, так и у детей и подростков. К настоящему времени сформировалось представление об эндотелиальной дисфункции как о состоянии, характеризующемся дисбалансом медиаторов, обеспечивающих в норме оптимальное течение эндотелий-зависимых процессов. В связи с доказанной ролью развития эндотелиальной дисфункции в патогенезе заболеваний сердечно-сосудистой, дыхательной систем, при метаболических нарушениях и т.д. в качестве такого прогностического и диагностического маркера эндотелиальной дисфункции может быть использован эндотелин-1 (EТ-1). Цель исследования: анализ и обобщение данных литературы по базам данных WoS, Scopus, РИНЦ. На основе клинических и экспериментальных данных можно заключить, что применение маркеров эндотелиальной дисфункции, включая уровень эндотелина-1 в сыворотке крови, может использоваться для оценки тяжести социально-значимых заболеваний при их манифестации в детском и подростковом возрасте.
The search for specific prognostic and diagnostic markers is an urgent task in modern pediatrics. The endothelium is an active system that functions as a receptor-effectors organ that responds to an exogenous or endogenous stimulus with the release of various molecules designed to restore vascular-tissue homeostasis. The endothelium, on the one hand, is involved in almost all processes defined as homeostasis, homeostasis and inflammation, on the other hand, it is the first link in the pathogenesis of various diseases in both adults, children and adolescents. To date, the idea of endothelial dysfunction as a condition characterized by an imbalance of mediators that normally ensure the optimal course of endothelium-dependent processes has been formed. Due to the proven role of the development of endothelial dysfunction in the pathogenesis of diseases of the cardiovascular, respiratory systems, metabolic disorders, etc. Endothelin-1 (ET-1) can be used as such a prognostic and diagnostic marker of endothelial dysfunction. Purpose of the study: analysis and synthesis of literature data using WoS, Scopus, RSCI databases. Based on clinical and experimental data, it can be concluded that the use of markers of endothelial dysfunction, including the level of endothelin-1 in blood serum, can be used to assess the severity of socially significant diseases when they manifest in childhood and adolescence.
PROVISION WITH CHILDREN'S DENTISTS IN SUGHD AND KHATLON REGIONS
Authors: Салимов Б.А. , Вохидов А. 
Published: May 2024

Цель. Изучить обеспеченность стоматологических учреждений Согдийской и Хатлонской областей врачами детскими стоматологами. Материал и методы. Работа основана на анализе отчетной формы 17, утвержденная приказом Агенство по статистикие при Президенте РТ № 054 от “11” октября 2013 г. Анализу были подвергнуты данные за период с 2017 по 2021 гг. Результаты. Общее число врачей, обслуживающих детей (детский стоматолог), в Хатлонской области за пять лет составило 82 (5,3%), в Согдийской 156 врача, различия статистически достоверно (р<0,001). В Согдийской области в 2021 г. показатель обеспеченности детскими стоматологами составляет – 0,237 на 10 тыс. детского населения, тогда как в Хатлонской области более чем в 2 раза ниже – 0,106 на 10 тыс. детского населения. Выводы. При меньшем числе детского населения в Согдийской области, в тоже время в 2 раза больше число врачей детских стоматологов, по сравнению с Хатлонской областью. Обеспеченность врачами детскими стоматологами в Хатлонской области в более чем 10 раз ниже, чем по стране и в 2 раза относительно Согдийской области.
Target. To study the availability of dental institutions in Sughd and Khatlon regions, pediatric dentists. Material and methods. The work is based on the analysis of the reporting form 17, approved by the order of the Agency for Statistics under the President of the Republic of Tajikistan No. 054 dated October 11, 2013. Data for the period from 2017 to 2021 were analyzed. Results. The total number of doctors serving children - a pediatric dentist in Khatlon region for five years was 82 (5.3%), in Sughd 156 doctors, the differences are statistically significant (p<0.001). In Sughd region in 2021 the indicator of provision with pediatric dentists is 0.237 per 10 thousand children. while in the Khatlon region it is more than 2 times lower - 0.106 per 10 thousand children. Conclusions. With a smaller number of children in the Sughd region, at the same time, the number of pediatric dentists is 2 times higher compared to the Khatlon region. The provision of pediatric dentists in Khatlon region is more than 10 times lower than in the country and 2 times lower than in Sughd region.
MODERN UNDERSTANDING OF THE POSSIBILITIES OF VACCINATION IN CHILDREN AND ADOLESCENTS WITH BRONCHIAL ASTHMA (LITERATURE REVIEW)
Authors: Файзуллина Р.М. , Гафурова Р.Р. , Чернышова А.Е. , Казакова Е.В. , Богомолова Е.А. 
Published: May 2024

На сегодняшний день бронхиальная астма продолжает оставаться одним из наиболее частых хронических неинфекционных заболеваний органов дыхания, что в свою очередь делает её глобальной проблемой системы здравоохранения. Современные международные и национальные руководства по ведению пациентов с бронхиальной астмой детского возраста выделяют значительную роль респираторных инфекций в патогенетических механизмах заболевания. Респираторные инфекции определяют фенотипическую реализацию бронхиальной астмы и служат наиболее частым триггером её обострения у детей и подростков. Воздействие вирусов на слизистую оболочку бронхиального дерева, колонизация бактериями приводит к её микробному повреждению и воспалению, там самым облегчая процесс проникновения аллергенов и, как следствие риску развития обострения бронхиальной астмы. Представленный нами систематизированный обзор литературы свидетельствуют об эффективности применения активной иммунизации пациентов с бронхиальной астмой. Использование вакцин для предупреждения или присоединения инфекций респираторного тракта у детей и подростков с бронхиальной астмой в сочетании с традиционными методами терапии приводит к уменьшению количества госпитализации, улучшения показателя уровня контроля над симптомами заболевания и повышения качества жизни.
To date, bronchial asthma continues to be one of the most frequent chronic non-communicable diseases of the respiratory system, which in turn makes it a global problem of the health system. Modern international and national guidelines for the management of children with bronchial asthma highlight the significant role of respiratory infections in the pathogenetic mechanisms of the disease. Respiratory infections determine the phenotypic realization of bronchial asthma and serve as the most frequent trigger of its exacerbation in children and adolescents. The impact of viruses on the mucous membrane of the bronchial tree, colonization by bacteria leads to its microbial damage and inflammation, thereby facilitating the penetration of allergens and, as a consequence, the risk of exacerbation of bronchial asthma. The systematic review of the literature presented by us indicates the effectiveness of the use of active immunization of patients with bronchial asthma. The use of vaccines to prevent or attach respiratory tract infections in children and adolescents with bronchial asthma in combination with traditional therapies leads to a decrease in the number of hospitalizations, an improvement in the level of control over the symptoms of the disease and an improvement in the quality of life.