bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of Recurrent Lateral Ankle Sprain and Ankle Pain Using Applied Care Strategies and Patient-Reported Outcomes
Authors: McCann Ryan S. , Ohrnberger Elisabeth , Kosik Kyle B. , Gribble Phillip A. 
Published: May 2024

Context
Patients with lateral ankle sprains (LASs) often have deficient patient-reported outcomes (PROs) at return to activity (RTA), potentially increasing risk for recurrent LAS and ankle pain. Additionally, applied care strategies are known to correct impairments, but their ability to mitigate risk for long-term consequences remains unknown.

Objective
To determine if applied care strategies and PRO scores at RTA and 6 months after RTA predict recurrent LAS and ankle pain 12 months after an acute LAS.

Design
Prospective cohort study.

Setting
Online survey.

Patients or Other Participants
We enrolled 63 individuals within 1 week of sustaining an acute LAS.

Main Outcome Measure(s)
Participants completed online surveys about their health history and recent LAS. At RTA and 6 months after RTA, participants completed online surveys regarding demographics, applied care strategies, and PROs, including the Foot and Ankle Disability Index (FADI), Identification of Functional Ankle Instability, Godin Leisure-Time Exercise Questionnaire, and Short Form-8 (SF8). At 12 months post-RTA, we asked participants if they sustained recurrent LASs. Chi-square analyses determined if recurrent LAS and ankle pain at 12 months were related to applied care strategies or ankle pain at RTA. Independent t tests compared demographics and PROs at RTA and 6 months between participants with and without a recurrent LAS or ankle pain at 12 months. Logistic regression and area under the receiver operating characteristic analyses determined if demographics, applied care strategies, ankle pain at RTA, and PRO scores at RTA and 6 months predicted recurrent LAS and ankle pain at 12 months.

Results
Participants with a recurrent LAS had a lower walking boot use (P = .05) and were taller than those without (P = .03). Increased height and lack of walking boot use were predictive of recurrent LAS (P &lt; .01, R2 = 0.33, area under the receiver operating characteristic = 0.81 [0.68, 0.95]).

Conclusions
Individuals with LAS who are taller and do not use a walking boot might have greater risk for a recurrent LAS withing 12 months of RTA.
Effect of calcium hydroxide on fracture resistance and microhardness of dentin in human teeth
Authors: Sethi Simar , Gupta Alpa , Kurian Ansy Hanna , Abraham Dax , Chauhan Parul , Aneja Kritika , Jala Sucheta , Singh Arundeep 
Published: May 2024

Aim:
Calcium hydroxide to date is a widely used intracanal medicament during endodontic treatment. Long duration of exposure of dentin to calcium hydroxide may influence the fracture resistance and microhardness of dentin thereby affecting the tooth. The aim of this review was to identify and systematically analyze the effect of calcium hydroxide on fracture resistance and microhardness of dentin in human teeth.

Methods:
A PubMed and Scopus search was performed using keywords 'fracture resistance' and 'microhardness' along with Medical Subject Heading (MeSH) terms 'Calcium hydroxide' and 'dentin' and 'tooth' till 12th March 2022. The reference list of each selected article was also explored to identify additional articles. An inclusion criteria was set that had to be met by each study for it to be selected for the review. Only articles written in English language were included in this systematic review. The review was conducted according to the PRISMA checklist.

Results:
Ten in-vitro studies that fulfilled the inclusion criteria were included in this review. The findings of majority of studies showed that an exposure duration of more than one month to calcium hydroxide decreased the fracture resistance and microhardness of dentin thereby affecting the strength of the tooth. Further, one week of exposure to calcium hydroxide did not show any significant change in fracture resistance.

Conclusion:
Based on the analysis of the studies included in this review, it can be concluded that increased duration of exposure of dentin to calcium hydroxide negatively affects the fracture resistance and microhardness, thereby weakening the tooth.
Robotic vs laparoscopic abdominoperineal resection for rectal cancer: A propensity score matching cohort study and meta-analysis
Authors: Song Li , Xu Wen-Qiong , Wei Zheng-Qiang , Tang Gang 
Published: May 2024

BACKGROUND
Robotic surgery (RS) is gaining popularity; however, evidence for abdominoperineal resection (APR) of rectal cancer (RC) is scarce.
AIM
To compare the efficacy of RS and laparoscopic surgery (LS) in APR for RC.
METHODS
We retrospectively identified patients with RC who underwent APR by RS or LS from April 2016 to June 2022. Data regarding short-term surgical outcomes were compared between the two groups. To reduce the effect of potential confounding factors, propensity score matching was used, with a 1:1 ratio between the RS and LS groups. A meta-analysis of seven trials was performed to compare the efficacy of robotic and laparoscopic APR for RC surgery.
RESULTS
Of 133 patients, after propensity score matching, there were 42 patients in each group. The postoperative complication rate was significantly lower in the RS group (17/42, 40.5%) than in the LS group (27/42, 64.3%) (P = 0.029). There was no significant difference in operative time (P = 0.564), intraoperative transfusion (P = 0.314), reoperation rate (P = 0.314), lymph nodes harvested (P = 0.309), or circumferential resection margin (CRM) positive rate (P = 0.314) between the two groups. The meta-analysis showed patients in the RS group had fewer positive CRMs (P = 0.04), lesser estimated blood loss (P < 0.00001), shorter postoperative hospital stays (P = 0.02), and fewer postoperative complications (P = 0.002) than patients in the LS group.
CONCLUSION
Our study shows that RS is a safe and effective approach for APR in RC and offers better short-term outcomes than LS.
Preoperative prognostic nutritional index predicts long-term outcomes of patients with ampullary adenocarcinoma after curative pancreatoduodenectomy
Authors: Sun Chong-Yuan , Zhang Xiao-Jie , Li Zheng , Fei He , Li Ze-Feng , Zhao Dong-Bing 
Published: May 2024

BACKGROUND
The prognostic nutritional index (PNI), a marker of immune-nutrition balance, has predictive value for the survival and prognosis of patients with various cancers.
AIM
To explore the clinical significance of the preoperative PNI on the prognosis of ampullary adenocarcinoma (AC) patients who underwent curative pancreaticoduodenectomy.
METHODS
The data concerning 233 patients diagnosed with ACs were extracted and analyzed at our institution from January 1998 to December 2020. All patients were categorized into low and high PNI groups based on the cutoff value determined by receiver operating characteristic curve analysis. We compared disease-free survival (DFS) and overall survival (OS) between these groups and assessed prognostic factors through univariate and multivariate analyses.
RESULTS
The optimal cutoff value for the PNI was established at 45.3. Patients with a PNI ≥ 45.3 were categorized into the PNI-high group, while those with a PNI < 45.3 were assigned to the PNI-low group. Patients within the PNI-low group tended to be of advanced age and exhibited higher levels of aspartate transaminase and total bilirubin and a lower creatinine level than were those in the PNI-high group. The 5-year OS rates for patients with a PNI ≥ 45.3 and a PNI < 45.3 were 61.8% and 43.4%, respectively, while the 5-year DFS rates were 53.5% and 38.3%, respectively. Patients in the PNI- low group had shorter OS (P = 0.006) and DFS (P = 0.012). In addition, multivariate analysis revealed that the PNI, pathological T stage and pathological N stage were found to be independent prognostic factors for both OS and DFS.
CONCLUSION
The PNI is a straightforward and valuable marker for predicting long-term survival after pancreatoduodenectomy. The PNI should be incorporated into the standard assessment of patients with AC.
Comparative observation of the effectiveness and safety of remimazolam besylate versus dexmedetomidine in gastrointestinal surgery in obese patients
Authors: Deng Yu-Fu , Jiang Xue-Run , Feng Zeng-Guang 
Published: May 2024

BACKGROUND
Surgery for obese patients carries a higher risk of anesthesia complications compared with surgery for nonobese patients. Thus, a safe and effective anesthesia strategy is necessary to improve the medical experience of such patients and ensure their safety.
AIM
To compared the effectiveness and safety of remimazolam besylate versus dexmedetomidine (DEX) in gastrointestinal surgery in obese patients.
METHODS
The study cohort included 60 obese patients undergoing gastrointestinal surgery between July 2021 and April 2023, comprising 30 patients who received DEX intervention (control group) and 30 patients who received remimazolam besylate intervention (research group). Heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP), blood oxygen saturation (SpO2), safety (nausea and vomiting, bradycardia, hypotension, and apnea), anesthesia and examination indices [induction time, anesthesia recovery time, and postanesthesia care unit (PACU) discharge time], sedation effect (Ramsay Sedation Scale), and postoperative pain visual analog scale were comparatively analyzed before anesthesia (T0), during anesthesia (T1), and after anesthesia (T2).
RESULTS
At T1, the research group showed significantly smaller changes in HR, RR, MAP, and SpO2 than the control group, with a significantly lower adverse reaction rate and shorter induction, anesthesia recovery, and PACU discharge times. Additionally, the intra- and postoperative Ramsay Sedation Scale scores were statistically higher in the research group than in the control group.
CONCLUSION
Remimazolam besylate was significantly more effective than DEX in gastrointestinal surgery in obese patients and had a higher safety profile and value in clinical promotion.
Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers
Authors: Diao Yu-Hang , Rao Si-Qi , Shu Xin-Peng , Cheng Yong , Tan Can , Wang Li-Juan , Peng Dong 
Published: May 2024

BACKGROUND
Preoperative serum tumor markers not only play a role in the auxiliary diagnosis and postoperative monitoring in colorectal cancer (CRC), but also have been found to have potential prognostic value.
AIM
To analyze whether preoperative serum tumor markers, including carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), affect the prognosis of CRC.
METHODS
This was a retrospective study conducted in a single center. Patients with nonmetastatic CRC who underwent initial surgery between January 2011 and January 2020 were enrolled and divided into development site and validation site groups at a ratio of 7:3. The independent prognostic factors were screened by Cox regression analysis, and finally, a prognostic nomogram model was established. The newly developed model was tested by internal validation.
RESULTS
Eventually, 3526 postoperative patients with nonmetastatic CRC were included in the study. There were 2473 patients at the development site and 1056 patients at the validation site. Age (P < 0.01, HR = 1.042, 95%CI = 1.033-1.051), tumor node metastasis (TNM) classification (P < 0.01, HR = 1.938, 95%CI = 1.665-2.255), preoperative CEA (P = 0.001, HR = 1.393, 95%CI = 1.137-1.707) and CA19-9 (P < 0.01, HR = 1.948, 95%CI = 1.614-2.438) levels were considered independent prognostic factors for patients with nonmetastatic CRC and were used as variables in the nomogram model. The areas under the curve of the development and validation sites were 0.655 and 0.658, respectively. The calibration plot also showed the significant performance of the newly established nomogram.
CONCLUSION
We successfully constructed a nomogram model based on age, TNM stage, preoperative CEA, and CA19-9 levels to evaluate the overall survival of patients with nonmetastatic CRC.
Treatment of anastomotic stricture after rectal cancer operation by magnetic compression technique: A case report
Authors: Zhang Miao-Miao , Sha Huan-Chen , Xue Hai-Rong , Qin Yuan-Fa , Dong Fang-Fang , Zhang Li , Lyu Yi , Yan Xiao-Peng 
Published: May 2024

BACKGROUND
The treatment of postoperative anastomotic stenosis (AS) after resection of colorectal cancer is challenging. Endoscopic balloon dilation is used to treat stenosis in such cases, but some patients do not show improvement even after multiple balloon dilations. Magnetic compression technique (MCT) has been used for gastrointestinal anastomosis, but its use for the treatment of postoperative AS after colorectal cancer surgery has rarely been reported.
CASE SUMMARY
We report a 72-year-old man who underwent radical resection of colorectal cancer and ileostomy one year ago. An ileostomy closure was prepared six months ago, but colonoscopy revealed a narrowing of the rectal anastomosis. Endoscopic balloon dilation was performed three times, but colonoscopy showed no significant improvement in stenosis. The AS was successfully treated using MCT.
CONCLUSION
MCT is a minimally invasive method that can be used for the treatment of postoperative AS after colorectal cancer surgery.
Patient-derived induced pluripotent stem cells with a MERTK mutation exhibit cell junction abnormalities and aberrant cellular differentiation potential
Authors: Zhang Hang , Wu Ling-Zi , Liu Zhen-Yu , Jin Zi-Bing 
Published: May 2024

BACKGROUND
Human induced pluripotent stem cell (hiPSC) technology is a valuable tool for generating patient-specific stem cells, facilitating disease modeling, and investigating disease mechanisms. However, iPSCs carrying specific mutations may limit their clinical applications due to certain inherent characteristics.
AIM
To investigate the impact of MERTK mutations on hiPSCs and determine whether hiPSC-derived extracellular vesicles (EVs) influence anomalous cell junction and differentiation potential.
METHODS
We employed a non-integrating reprogramming technique to generate peripheral blood-derived hiPSCs with and hiPSCs without a MERTK mutation. Chromosomal karyotype analysis, flow cytometry, and immunofluorescent staining were utilized for hiPSC identification. Transcriptomics and proteomics were employed to elucidate the expression patterns associated with cell junction abnormalities and cellular differentiation potential. Additionally, EVs were isolated from the supernatant, and their RNA and protein cargos were examined to investigate the involvement of hiPSC-derived EVs in stem cell junction and differentiation.
RESULTS
The generated hiPSCs, both with and without a MERTK mutation, exhibited normal karyotype and expressed pluripotency markers; however, hiPSCs with a MERTK mutation demonstrated anomalous adhesion capability and differentiation potential, as confirmed by transcriptomic and proteomic profiling. Furthermore, hiPSC-derived EVs were involved in various biological processes, including cell junction and differentiation.
CONCLUSION
HiPSCs with a MERTK mutation displayed altered junction characteristics and aberrant differentiation potential. Furthermore, hiPSC-derived EVs played a regulatory role in various biological processes, including cell junction and differentiation.
Effect of ginsenoside Rg1 on hematopoietic stem cells in treating aplastic anemia in mice via MAPK pathway
Authors: Wang Jin-Bo , Du Ming-Wei , Zheng Yan 
Published: May 2024

BACKGROUND
Aplastic anemia (AA) presents a significant clinical challenge as a life-threatening condition due to failure to produce essential blood cells, with the current therapeutic options being notably limited.
AIM
To assess the therapeutic potential of ginsenoside Rg1 on AA, specifically its protective effects, while elucidating the mechanism at play.
METHODS
We employed a model of myelosuppression induced by cyclophosphamide (CTX) in C57 mice, followed by administration of ginsenoside Rg1 over 13 d. The investigation included examining the bone marrow, thymus and spleen for pathological changes via hematoxylin-eosin staining. Moreover, orbital blood of mice was collected for blood routine examinations. Flow cytometry was employed to identify the impact of ginsenoside Rg1 on cell apoptosis and cycle in the bone marrow of AA mice. Additionally, the study further evaluated cytokine levels with enzyme-linked immunosorbent assay and analyzed the expression of key proteins in the MAPK signaling pathway via western blot.
RESULTS
Administration of CTX led to significant damage to the bone marrow’s structural integrity and a reduction in hematopoietic cells, establishing a model of AA. Ginsenoside Rg1 successfully reversed hematopoietic dysfunction in AA mice. In comparison to the AA group, ginsenoside Rg1 provided relief by reducing the induction of cell apoptosis and inflammation factors caused by CTX. Furthermore, it helped alleviate the blockade in the cell cycle. Treatment with ginsenoside Rg1 significantly alleviated myelosuppression in mice by inhibiting the MAPK signaling pathway.
CONCLUSION
This study suggested that ginsenoside Rg1 addresses AA by alleviating myelosuppression, primarily through modulating the MAPK signaling pathway, which paves the way for a novel therapeutic strategy in treating AA, highlighting the potential of ginsenoside Rg1 as a beneficial intervention.
ALGUMAS NOTAS PEDAGÓGICAS SOBRE AS PERSPECTIVAS E OS DESAFIOS DO ENSINO DE LÍNGUA ESTRANGEIRA NA ESCOLA PÚBLICA
Authors: Malta Daniela Paula de Lima Nunes , Esprendor Aline , Luz Ana Carolina Rodrigues da , Souza Átila de , Alves Daiane de Lourdes 
Published: May 2024

O presente trabalho tem como objetivo tratar de algumas dificuldades vivenciadas por professores e alunos no decorrer do processo do ensino e aprendizagem de língua estrangeira. Refere-se a um estudo bibliográfico sobre o assunto, tendo como contribuição de trabalhos referentes à formação de professores de línguas, tal como estudos recentes na área de linguística aplicada ao ensino e aprendizagem de línguas. Os estudos mostram que as mudanças da Era chamada pós-moderna, no âmbito da sociedade globalizada impulsiona as mudanças ocorridas e os desafios enfrentados pelos professores e alunos. Perante essa realidade, compreendemos que a formação docente é um contínuo processo de transformação, que nunca deverá vangloria-se de se declarar concluído, visto que o mundo está em um continuado processo de mudança. Desse modo, a constante busca por meios e artifícios eficazes para resolver os obstáculos faz com que o docente seja motivado a buscar sempre o desenvolvimento profissional, de modo a assegurar a aprendizagem de seu aluno.
Українська медієвістика (рання новістика) в особах дослідників: Сергій Плохій у спогадах о. проф. Юрія Мицика
Authors: Венгер А.Г. 
Published: May 2024

У публікації наведено спогади доктора історичних наук, професора Юрія Мицика про одного зі своїх учнів – професора Гарвардського університету Сергія Плохія. Історики вперше перетнулися в середині 1970-х рр. на історичному факультеті Дніпропетровського державного університету. Юрій Мицик був викладачем кафедри загальної історії, а Сергій Плохій – студентом першого курсу. У спогадах розкриваються обставини знайомства та початку наукової роботи молодого історика під керівництвом Юрія Мицика. Саме з подачі останнього Сергій Плохій почав досліджувати латиномовну історіографію, написав перші наукові розвідки та опублікував статті. Окрім того, професор розповідає про проблеми, які виникли перед його учнем під час вступу до аспірантури,і проте, як йому вдалося їх подолати.
Історик згадує і про підготовку Сергієм Плохієм кандидатської дисертації «Латиномовні твори середини XVII століття як джерело з історії Визвольної війни українського народу 1648–1654 рр.» в університеті ім. Патріса Лумумби в Москві.
Особливий інтерес становлять сюжети особистих дружніх контактів та міжродинного спілкування істориків. Юрій Мицик розповідає про прихід Сергія Плохія на кафедру загальної історії як викладача, про його зростання, просування кар’єрними сходами та про участь у житті історичного факультету. Про непрості стосунки істориків під час балотування та обрання Сергія Плохія завідувачем кафедри, роботу деканом факультету для іноземних студентів та обставини, за яких він був змушений покинути Дніпропетровський університет. Окрема частина спогадів присвячена закордонним відрядженням Сергія Плохія та враженнями від них, якими він ділився з колегами, про спільну поїздку на міжнародну конференцію в Італію.
Частина спогадів присвячена контактам істориків у часи, коли вони обидва припинили працювати в Дніпропетровському університеті та зустрічалися під час стажування Юрія Мицика в Канаді.
Resisting
Authors: McNamara Sarah 
Published: May 2024

Abstract
Chapter 2, “Resisting,” chronicles the culture of labor unionism and leftist political ideologies that governed Latinas/os’ understanding of self and guided them as they battled oppression from cigar manufacturers, vigilantes, and the city of Tampa. The focus of this chapter is the 1930s, the period during which the power of the Cuban cigar industry began to decline, but also the same era during which Latinas rose as powerful political advocates for themselves and their communities as these women fought, what they understood was, fascism abroad and fascism at home.
Prologue
Authors: Afkhami Mahnaz 
Published: May 2024

Abstract
The Prologue initiates the reader into the story of the author’s life in Iran, a country in an intense struggle between tradition and modernity, and in the United States, where since the late 1970s she has lived in exile—a condition that allows her to belong to both countries and to neither—looking at both as an outsider but seeing each from within. It also describes the scene in which the author learned that for her own safety, she could not return to Iran. The Prologue introduces the reader to the author’s role in the Women’s Organization of Iran (WOI), her work with women’s rights in Iran, her role as Iran’s first-ever Minister for Women’s Affairs, her dealings with Iran’s royal family, her work in global feminist movement building, and her founding of Women’s Learning Partnership (WLP), an international women’s organization by and for women from the Global South.
Coming to America
Authors: Afkhami Mahnaz 
Published: May 2024

Abstract
This chapter recounts the author’s travel to America as a young teen, to begin a new life with her mother in San Francisco; her being urged to select a new name, which became her American identity; and her settling into a new life in Seattle, where she was sent to live with an American family and go to school, and where her “Americanization” began. Able to graduate early, at sixteen she enrolled at San Francisco State College. She soon fell in love with and married Gholam Reza Afkhami. At seventeen, she secured a position in the Kress Variety Store and joined a union. There she realized the importance of speaking up for her and other workers’ rights, which taught her the power of working with others and that when women band together, they can protect one another from injustice. In 1963, the author and her husband travelled to Iran, which was changing as a result of the reforms instituted by the White Revolution of 1963, opposed by Iran’s clerics. In 1967, Iran’s Majlis passed the Family Protection Law, which threatened even more the clerics’ concept of societal organization founded on women’s role as secondary in the family and society.