bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface Engineering of Biochar Toward Simultaneously Generating Superamphiphilicity and Catalytic Activity for Strengthening Pickering Interfacial Catalysis
Authors: Fan Honglei , Wang Qiuxia , Liu Hongliang , Han Buxing , Liu Huizhen , Yang Guanying 
Published: May 2024

AbstractMultifunctional carbon materials have revealed distinctive features and excellent performance in the field of catalysis. However, the facile fabrication of bifunctional carbon materials with special wettability and catalytic activity remains a grand challenge in Pickering emulsion catalysis. Herein, we reported one‐step construction of bifunctional biochar with superamphiphilicity and catalytic activity directly from the thermolysis of sawdust and 1‐butyl‐3‐methylimidazolium tetrafluoroborate for enhancing the oxidation of benzyl alcohol in Pickering emulsion. Co‐doping of B and F enhanced the hydrophilicity of biochar, and the oleophilicity of biochar was kept simultaneously. Conversion became 4 times using bifunctional biochar compared with blank results during the oxidation of benzyl alcohol. More interestingly, the turnover frequency (TOF) value using bifunctional biochar enhanced 61 % than that employing N‐doped superamphiphilic carbon without catalytic activity. Catalytic activities of bifunctional biochar could be ascribed to the existence of different chemical bonds containing the element B. This work paves a path toward rational design of bifunctional biochar materials with special wettability and catalytic activity for greatly enhancing the liquid‐liquid biphasic reaction efficiencies.
A General and Highly Versatile Heterogeneous Pd‐Catalyzed Oxidative Aminocarbonylation of Alkynes with Aromatic and Aliphatic Amines
Authors: Arango‐Daza Juan Camilo , Cabrero‐Antonino Jose R. , Adam Rosa 
Published: May 2024

AbstractAn efficient heterogeneous catalytic system for the oxidative aminocarbonylation of alkynes and amines in the presence of CO/O2 to afford substituted propiolamides has been developed. The active nanocatalyst, [Pd/Mg3Al‐LDH]‐300(D), is composed by Pd nanoaggregates (2–3 nm average particle size) stabilized over a partially dehydrated [Mg3Al‐LDH] matrix. The methodology has resulted widely applicable, being the first catalytic system, either homogeneous or heterogeneous, able to activate not only aliphatic amines but also poorly‐nucleophilic aromatic amines. In fact, >60 substituted propiolamides have been synthesized in good to excellent isolated yields through this methodology, being 27 novel compounds. An important characterization effort (XRD, 27Al MAS NMR, TGA, TPD‐CO2, BET area, XPS, HAADF‐HRSTEM and HRTEM) and optimization of the synthesis conditions of the optimal catalyst has been performed. This study, together with a series of kinetic and mechanistic essays, indicates that the optimal catalyst is composed by Pd(0) species stabilized in a partially dehydrated/dehydroxylated LDH material with a Mg/Al molar ratio of 3 and a small crystallite size. All the experimental data indicates that the in situ formation of [PdI2] active species in the material surface together with the presence of a matrix with the optimal acid/base properties are key aspects of this process.
Optimisation of a primary human CAR‐NK cell manufacturing pipeline
Authors: Pfefferle Aline , Contet Julian , Wong Kahlia , Chen Charlotte , Verhoeyen Els , Slichter Chloe K , Schluns Kimberly S , Cursons Joseph , Berry Richard , Nikolic Iva , Rautela Jai , Huntington Nicholas D 
Published: May 2024

AbstractObjectivesAutologous chimeric antigen receptor (CAR) T‐cell therapy of B‐cell malignancies achieves long‐term disease remission in a high fraction of patients and has triggered intense research into translating this successful approach into additional cancer types. However, the complex logistics involved in autologous CAR‐T manufacturing, the compromised fitness of patient‐derived T cells, the high rates of serious toxicities and the overall cost involved with product manufacturing and hospitalisation have driven innovation to overcome such hurdles. One alternative approach is the use of allogeneic natural killer (NK) cells as a source for CAR‐NK cell therapy. However, this source has traditionally faced numerous manufacturing challenges.MethodsTo address this, we have developed an optimised expansion and transduction protocol for primary human NK cells primed for manufacturing scaling and clinical evaluation. We have performed an in‐depth comparison of primary human NK cell sources as a starting material by characterising their phenotype, functionality, expansion potential and transduction efficiency at crucial timepoints of our CAR‐NK manufacturing pipeline.ResultsWe identified adult peripheral blood‐derived NK cells to be the superior source for generating a CAR‐NK cell product because of a higher maximum yield of CAR‐expressing NK cells combined with potent natural, as well as CAR‐mediated anti‐tumor effector functions.ConclusionsOur optimised manufacturing pipeline dramatically improves lentiviral transduction efficiency of primary human NK cells. We conclude that the exponential expansion pre‐ and post‐transduction and high on‐target cytotoxicity make peripheral blood‐derived NK cells a feasible and attractive CAR‐NK cell product for clinical utility.
Corners‐slotted wideband patch antenna gain enhancement with a 3D dielectric lens for Ka‐band satellite communication
Authors: Ullah Naveed , Rahman Saeed Ur , Liu Yuhuai , Wang Fang 
Published: May 2024

SummaryTo improve the gain of the corner‐slotted, wideband microstrip patch antenna (MPA), a three‐dimensional (3D) hemispherical dielectric lens (DL) and dielectric cylinder‐based hybrid structure is introduced. DL is constructed and integrated on the surface of the patch antenna to increase the gain performance. Three‐dimensional printing techniques contribute considerably to lens production. The 3D manufacturing technique provides greater freedom and versatility than conventional manufacturing methods. The DL increased the proposed single‐patch antenna gain from 6.2 to 13.7 dBi with stable gain fluctuation in the working frequency spectrum spanning between 27.5 and 31 GHz. This implies a notable increase in gain of 7.5 dBi and a consistently uniform gain characteristic throughout a 5‐GHz wide frequency range. Furthermore, the DL‐loaded antenna parameters such as |S11|, gain (dBi), axial ratio (AR), radiation efficiency (%), and radiation patterns measured results are compared with simulated plots. Overall, the measured results agree well with the simulated findings. Based on the results, the compact antenna can be chosen for different wireless applications, especially for satellite communication in the proposed band.
Phylogenetic placement and comparative analysis of the mitochondrial genomes of Idiostoloidea (Hemiptera: Heteroptera)
Authors: Zhang Danli , Chen XiaoYan , Yang Jingjing , Yi Wenbo , Xie Qiang , Yang HuanHuan , Sweet Merrill H. , Bu Wenjun , Li Teng 
Published: May 2024

AbstractThe classification system and the higher level phylogenetic relationships of Pentatomomorpha, the second largest infraorder of Heteroptera (Insecta: Hemiptera), have been debated and remain controversial over decades. In particular, the placement and phylogenetic relationship of Idiostoloidea are not well resolved, which hampers a better understanding of the evolutionary history of Pentatomomorpha. In this study, for the first time, we reported the complete mitochondrial genome for two narrowly distributed families of Idiostoloidea (including Idiostolidae and Henicocoridae), respectively. The length of the mitochondrial genome of Monteithocoris hirsutus and Henicocoris sp. is 16,632 and 16,013 bp, respectively. The content of AT is ranging from 75.15% to 80.48%. The mitogenomic structure of Idiostoloidea is highly conservative and there are no gene arrangements. By using the Bayesian inference, maximum likelihood, and Bayesian site‐heterogeneous mixture model, we inferred the phylogenetic relationships within Pentatomomorpha and estimated their divergence times based on concatenated mitogenomes and nuclear ribosomal genes. Our results support the classification system of six superfamilies within Pentatomomorpha and confirm the monophyletic groups of each superfamily, with the following phylogenetic relationships: (Aradoidea + (Pentatomoidea + (Idiostoloidea + (Coreoidea + (Pyrrhocoroidea + Lygaeoidea))))). Furthermore, estimated divergence times revealed that most pentatomomorphan superfamilies and families diverged during the Late Jurassic to Early Cretaceous, which coincides with the explosive radiation of angiosperms.
Comparative Assessment of ESI‐MS Softness for Inorganic Complexes: How Soft Is Your ESI‐MS?
Authors: Chagunda Ian C. , Williams Peter J. H. , Fisher Tiago , Stock Naomi L. , Beach Daniel G. , Thomas Gilian T. , Zhu Jane , McIndoe J. Scott 
Published: May 2024

AbstractElectrospray ionization mass spectrometry (ESI‐MS) is a powerful tool for identifying and characterizing organometallic and coordination compounds. However, detection of fragile structures bound by weaker intermolecular forces can be significantly limited in ESI‐MS owing to the use of relatively harsh instrument conditions and configurations. In this study, a set of tests was developed to assess the softness of ESI‐MS systems. Two variants are presented: positive ion mode, utilizing a mixture of sodium ions and triphenylphosphine oxide producing [Na(OPPh3)n]+ ions (n=1–4), and negative ion mode utilizing Pd(PPh3)4 and sulfonated triphenylphosphine producing [Pd(L)(PPh3)n]− ions (n=0–2), where softer instrument conditions preserve a higher proportion of the high‐coordinate ions and harsher conditions will result in increased detection of products of ion fragmentation. The results revealed notable variations in instrument softness, which were influenced by a combination of instrument design and experimental parameters. Meticulously optimizing experimental conditions and ESI‐MS parameters is essential to achieving the softest ionization possible, ensuring reliable analysis where applicable. This study offers valuable insight through straightforward tests that can be employed to assess the suitability of an instrument for specific research needs.
Introduction of Organic Dyes into Cadmium(II) MOF for Tunable Light Emission and Highly Sensitive Probing Antibiotics
Authors: Wu Haozhen , Yang Guo‐Ping , Wang Yao‐Yu 
Published: May 2024

AbstractA honeycomb porous cadmium(II) metal–organic framework {[Cd(L)(H2O)] ⋅ NMP ⋅ 5H2O}n (1, H2L=1‐(4‐carboxyphenyl)‐1H‐pyrazole‐3‐carboxylic acid and NMP=1‐methyl‐2‐pyrrolidinone) was obtained using the solvothermal method. The luminescent molecules rhodamine B (RhB) and fluorescein (FL) were encapsulated in 1 using the immersion method to prepare RhB@1 and FL@1 dual emission composites. Additionally, a series of RhBx/FL1‐x@1 composites with varying luminescence properties were generated by altering the molar ratio of RhB to FL. Furthermore, the photoluminescence of RhB@1 and FL@1 was demonstrated to be caused by photoelectron transfer and fluorescence resonance energy transfer from 1 to the encapsulated guest module. Notably, RhB@1 showed the considerable improvement in fluorescence selectivity and detection limit (10−6 M) for metronidazole and dimetronidazole with remarkable recyclability.
Enhancing heavy‐oil displacement efficiency through viscoelasticity of polymer solution by investigating the viscosity limit of crude oil: An experimental study
Authors: Xue Xinsheng , Zhu Shijie , Ma Xinjian , Zhang Shilun , Yang Shuanglai , Huang Zhuangzhuang , Xu Mei , Huang Huirong 
Published: May 2024

AbstractThe world is rich in ordinary heavy‐oil resources. Exploring the limit of the crude oil viscosity limits can further expand the application of polymer flooding technology in heavy‐oil reservoirs and improve the development efficiency of heavy‐oil reservoirs. On the basis of the polymer flooding that has been implemented in the Bohai offshore oilfield, this study characterized the in situ viscoelasticity of the polymer solution SNF3640C. We compared the polymer flooding and glycerol flooding performance in low‐viscous oil reservoirs (with a viscosity of 6.5 cp) and high‐viscous oil reservoirs (with a viscosity of 65 cp) by conducting microscopic dead‐end experiments and macroscopic core‐flooding experiments, and then analyzing the impact of polymer's viscoelasticity on the oil displacement efficiency of heavy oil. Finally, multiple crude oils with a wide range of viscosity were used to explore the crude oil viscosity limits under which the efficiency of heavy‐oil displacement could be improved through polymer viscoelasticity. The results demonstrate that: (1) the SNF3640C polymer solution can exhibit a certain degree of viscoelasticity in deep formation. At a distance of 140 m from the wellbore in the reservoir, a solution with a concentration of 1500 mg/L can still have a first normal stress difference of 2.5 Pa. Polymers can effectively improve the efficiency of heavy‐oil displacement through elastic action. (2) The viscosity limit that can improve the efficiency of heavy‐oil displacement under current experimental conditions does not exceed 5486 cp. The efficiency of polymer flooding for crude oil has decreased to 31.68%, and the contribution of elastic flooding is only 1.5%. The research method of using viscous glycerol as a comparison to demonstrate the contribution of polymer elasticity to oil displacement effectiveness effectively solves the problem of isolating the contribution by polymer solution's viscosity and elasticity, and clarifies the development direction of polymer flooding for developing heavy crude oil. Enhancing the elastic effect of polymer solution in porous media can increase the viscosity range of polymer flooding heavy oil.
Deformation mechanism of gob‐side entry at top coal caving mining face: A numerical study
Authors: Zhang Jie , Gao Shoushi , Yang Tao , He Yifeng , Sun Jianping , Luo Pengkun , Bao Ruoyu 
Published: May 2024

AbstractTo investigate the significant deformation of the surrounding rock within the dynamic pressure zone of the gateroad, this study utilized the tailgate of the 1506 longwall face in Anyang Coal Mine as the engineering context. A combined approach of field measurement and numerical analysis was employed to explore the deformation and failure mechanisms of the surrounding rock under dynamic pressure. The findings indicate that before the exploitation of the 1506 longwall face, there was a notable reduction in stress across the floor and immediate roof, with minimal stress concentration observed in the coal pillar and the entity rib side. The plastic zone surrounding the tailgate was limited, suggesting a high degree of stability in the entry's surrounding rock. However, during the extraction of the 1506 longwall face, the tailgate, extending 60 m ahead of the working face, was subjected to dynamic pressure, leading to a marked increase in stress within the floor, coal pillar, and immediate roof. Stress concentration was more pronounced on the entity rib side than on the pillar rib side. This resulted in significant fissuring and severe deformation of the entry's surrounding rock. The primary failure mechanism involved damage to both the roof and floor corners, with the severity of damage escalating alongside the stress in the surrounding rock. This culminated in the failure of roof corner bolts and anchor cables, thereby compromising the stability of the entry within the dynamic pressure zone.
Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation
Authors: Vinothkanna Annadurai , Shi‐Liang Xiang , Karthick Rajan Durairaj , Prathiviraj Ragothaman , Sekar Soundarapandian , Zhang Shubing , Wang Bo , Liu Zhu , Jia Ai‐Qun 
Published: May 2024

AbstractPeople with diabetes mellitus (DM) and hyperglycemia are linked with cancer risk. Diabetes and cancer have been corroborated by high morbidity and mortality rates. Studies revealed that elevated levels of insulin secretions trigger insulin‐like growth factor 1 (IGF‐1) production. Moreover, IGF‐1 is a key regulator involved in promoting cancer cell progression and is linked with DM. Cancer drug resistance and ototoxic effects can adversely affect the health and lifespan of an individual. However, naturally derived bioactive compounds are gaining attention for their nontoxic properties and specific behavior. Likewise, probiotics have also been regarded as safe and successful alternatives to treat DM‐linked cancers. The present review aims to highlight the therapeutic potential and feasible functions of probiotics to mitigate or inhibit DM‐associated cancers. Meanwhile, the intracellular signaling cascades involved in promoting DM‐linked cancer are enumerated for future prospective research. However, metabolomics interactions and protein–protein interactions are to be discussed for deeper insights into affirmative principles in diabetic‐linked cancers. Drug discovery and innovative preclinical evaluation need further adjuvant and immune‐enhancement therapies. Furthermore, the results of the in silico assessment could provide scientific excellence of IGF‐1 in diabetes and cancer. Overall, this review summarizes the mechanistic insights and therapeutic targets for diabetes‐associated cancer.
The potential value of oral microbial signatures for prediction of oral squamous cell carcinoma based on machine learning algorithms
Authors: He Baochang , Cao Yujie , Zhuang Zhaocheng , Deng Qingrong , Qiu Yu , Pan Lizhen , Zheng Xiaoyan , Shi Bin , Lin Lisong , Chen Fa 
Published: May 2024

AbstractObjectiveThis study aimed to explore the potential predictive value of oral microbial signatures for oral squamous cell carcinoma (OSCC) risk based on machine learning algorithms.MethodsThe oral microbiome signatures were assessed in the unstimulated saliva samples of 80 OSCC patients and 179 healthy individuals using 16S rRNA gene sequencing. Four different machine learning classifiers were used to develop prediction models.ResultsCompared with control participants, OSCC patients had a higher microbial dysbiosis index (MDI, p < 0.001). Among four machine learning classifiers, random forest (RF) provided the best predictive performance, followed by the support vector machines, artificial neural networks and naive Bayes. After controlling the potential confounders using propensity score matching, the optimal RF model was further developed incorporating a minimal set of 20 bacteria genera, exhibiting better predictive performance than the MDI (AUC: 0.992 vs. 0.775, p < 0.001).ConclusionsThe novel MDI and RF model developed in this study based on oral microbiome signatures may serve as noninvasive tools for predicting OSCC risk.
Validation of a low‐cost lead hazard screening kit for the home environment
Authors: Wicks Alyssa , Joseph Ornella , Keranen Jocelyn , Herrmann Angela , Lieberman Marya , Peaslee Graham F. , Sisk Matthew L. , Filippelli Gabriel , Beidinger‐Burnett Heidi 
Published: May 2024

AbstractThe main sources of lead exposure for children occur in the home environment, yet no low‐cost analytical methods exist to screen homes for lead hazards. Previously, an inexpensive (~$20), quantitative lead screening kit was developed in which residents collect soil, paint, and dust samples that are returned to a laboratory for lead analysis using X‐ray fluorescence spectroscopy (XRF). This screening kit was initially validated in 2020; it was determined that in situ and ex situ XRF lead measurements on the same samples exhibited strong sensitivity, specificity, and accuracy. As a follow‐up to the initial validation, an implementation study and further statistical analyses were conducted. Correlation analysis using the results from nearly 400 screening kits identified an overall lack of correlation between sample types, reinforcing the utility of all eight sample locations. Principal component analysis searched for underlying correlations in sample types and provided evidence that both interior and exterior paint are major sources of lead hazards for Indiana homes. The implementation study compared the results of the government‐standard lead inspection and risk assessment (LIRA) and the lead screening kit in 107 Indiana homes. In the United States, the LIRA is a thorough inspection of paint, dust, and soil that is usually state mandated in response to a child's elevated blood level and is used to identify where remediation efforts should be focused. The lead screening kit and LIRA agreed on the presence of lead in 79 of the 107 homes tested (74%). Discrepancies in agreement are likely the result of differences in the sample location and number of samples collected by each method. Overall, these results suggest that the lead screening kit is an acceptable resource that could be used to expand the services health departments provide for lead prevention. Integr Environ Assess Manag 2024;20:1504–1513. © 2024 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Post‐diagnosis dietary factors, supplement use and colorectal cancer prognosis: A Global Cancer Update Programme (CUP Global) systematic literature review and meta‐analysis
Authors: Chan Doris S. M. , Cariolou Margarita , Markozannes Georgios , Balducci Katia , Vieira Rita , Kiss Sonia , Becerra‐Tomás Nerea , Aune Dagfinn , Greenwood Darren C. , González‐Gil Esther M. , Copson Ellen , Renehan Andrew G. , Bours Martijn , Demark‐Wahnefried Wendy , Hudson Melissa M. , May Anne M. , Odedina Folakemi T. , Skinner Roderick , Steindorf Karen , Tjønneland Anne , Velikova Galina , Baskin Monica L. , Chowdhury Rajiv , Hill Lynette , Lewis Sarah J. , Seidell Jaap , Weijenberg Matty P. , Krebs John , Cross Amanda J. , Tsilidis Konstantinos K. 
Published: May 2024

AbstractThe role of diet in colorectal cancer prognosis is not well understood and specific lifestyle recommendations are lacking. We searched for randomised controlled trials (RCTs) and longitudinal observational studies on post‐diagnosis dietary factors, supplement use and colorectal cancer survival outcomes in PubMed and Embase from inception until 28th February 2022. Random‐effects dose–response meta‐analyses were conducted when at least three studies had sufficient information. The evidence was interpreted and graded by the CUP Global independent Expert Committee on Cancer Survivorship and Expert Panel. Five RCTs and 35 observational studies were included (30,242 cases, over 8700 all‐cause and 2100 colorectal cancer deaths, 3700 progression, recurrence, or disease‐free events). Meta‐analyses, including 3–10 observational studies each, were conducted for: whole grains, nuts/peanuts, red and processed meat, dairy products, sugary drinks, artificially sweetened beverages, coffee, alcohol, dietary glycaemic load/index, insulin load/index, marine omega‐3 polyunsaturated fatty acids, supplemental calcium, circulating 25‐hydroxyvitamin D (25[OH]D) and all‐cause mortality; for alcohol, supplemental calcium, circulating 25(OH)D and colorectal cancer‐specific mortality; and for circulating 25(OH)D and recurrence/disease‐free survival. The overall evidence was graded as ‘limited’. The inverse associations between healthy dietary and/or lifestyle patterns (including diets that comprised plant‐based foods), whole grains, total, caffeinated, or decaffeinated coffee and all‐cause mortality and the positive associations between unhealthy dietary patterns, sugary drinks and all‐cause mortality provided ‘limited—suggestive’ evidence. All other exposure‐outcome associations provided ‘limited—no conclusion’ evidence. Additional, well‐conducted cohort studies and carefully designed RCTs are needed to develop specific lifestyle recommendations for colorectal cancer survivors.