bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global trends in chronic kidney disease-related mortality: a systematic review protocol
Authors: Tungsanga Somkanya , Ghimire Anukul , Hariramani Vinash K , Abdulrahman Abdullah , Khan Ana S , Ye Feng , Kung Janice Y , Klarenbach Scott , Thompson Stephanie , Collister David , Srisawat Nattachai , Okpechi Ikechi G , Bello Aminu K 
Published: May 2024

IntroductionIn recent decades, all-cause mortality has increased among individuals with chronic kidney disease (CKD), influenced by factors such as aetiology, standards of care and access to kidney replacement therapies (dialysis and transplantation). The recent COVID-19 pandemic also affected mortality over the past few years. Here, we outline the protocol for a systematic review to investigate global temporal trends in all-cause mortality among patients with CKD at any stage from 1990 to current. We also aim to assess temporal trends in the mortality rate associated with the COVID-19 pandemic.Methods and analysisWe will conduct a systematic review of studies reporting mortality for patients with CKD following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We will search electronic databases, national and multiregional kidney registries and grey literature to identify observational studies that reported on mortality associated with any cause for patients with CKD of all ages with any stage of the disease. We will collect data between April and August 2023 to include all studies published from 1990 to August 2023. There will be no language restriction, and clinical trials will be excluded. Primary outcome will be temporal trends in CKD-related mortality. Secondary outcomes include assessing mortality differences before and during the COVID-19 pandemic, exploring causes of death and examining trends across CKD stages, country classifications, income levels and demographics.Ethics and disseminationA systematic review will analyse existing data from previously published studies and have no direct involvement with patient data. Thus, ethical approval is not required. Our findings will be published in an open-access peer-reviewed journal and presented at scientific conferences.PROSPERO registration numberCRD42023416084.
Peroperative administration of tranexamic acid in Roux-en-Y and one-anastomosis gastric bypass to reduce haemorrhage in patients with morbid obesity: protocol for randomised controlled trial (PATRY trial)
Authors: 't Hart Judith W H , Noordman Bo J , Palsgraaf-Huisbrink Jeannine , Dunkelgrun Martin , Zengerink Hans F , Birnie Erwin , van Det Marc J , Boerma Evert-Jan G , de Castro Steve M M , Hazebroek Eric J , Langenhoff Barbara S , Verhoef Cornelis , Apers Jan A 
Published: May 2024

IntroductionBy implementation of Enhanced Recovery After Bariatric Surgery protocols and day-care surgery, early discharge poses a challenge if excessive bleeding occurs after bariatric surgery. Tranexamic acid (TXA) has demonstrated efficacy in other surgical fields and in bariatric pilot studies. This trial aims to assess the efficacy of peroperative administration of TXA in reducing haemorrhage in patients undergoing gastric bypass surgery.Method and analysisThis is a multicentre, phase III, double-blind randomised controlled trial in six high-volume bariatric centres in the Netherlands. A total of 1524 eligible patients, aged 18 years or older, undergoing primary gastric bypass surgery (either Roux-en-Y gastric bypass or one-anastomosis gastric bypass) will be randomised between TXA and placebo (1:1, variable block, stratified for centre, day-care/overnight stay and type of surgery) after obtaining informed consent (2.5% less haemorrhage, power 80%, 2-sided-α 0.05 and 10% dropout). Exclusion criteria are pregnancy, amedical history of acute bleeding (without cause), venous thrombotic events (VTEs), epilepsy, anticoagulant use and iatrogenic bleeding during surgery (aside from staple line). The primary outcome is postoperative haemorrhage requiring intervention within 30 days postoperatively. Secondary outcome measures are staple line reinforcement, blood loss, duration of surgery, postoperative haemoglobin, vital parameters, minor and major complications, side effects of TXA (nausea, hypotension and VTE), length of hospital stay and directly made costs.Ethics and disseminationWritten informed consent will be obtained from all participants. The protocol has been approved by the Medical Research Ethics Committees United, Nieuwegein, on 7 February 2023 (registration number: R22.102). Results will be disseminated through peer-reviewed publications and conferences.Trial registration numberNCT05464394
Prescriber decision-making on antithrombotic therapy after endovascular intervention for peripheral artery disease: a protocol for a discrete choice experiment
Authors: Zhu Alison , Tang Robert , Rajendran Saissan , Hajian Hamid , Aitken Sarah Joy 
Published: May 2024

IntroductionPeripheral artery disease (PAD) is a major risk factor for cardiovascular morbidity and mortality, despite surgical and endovascular treatments. Emerging evidence supports the use of immediate antithrombotic medications after endovascular intervention for PAD, however, there is a lack of consensus regarding choice and duration of antithrombotic therapy. Prescriber decision-making is a complex process, with prior studies demonstrating patient factors can influence variability in antithrombotic therapy for PAD. However, it remains unclear the relative contribution of these factors. This paper describes a planned study that aims to (1) determine the influence of patient factors on clinician preference for antithrombotic therapy following endovascular intervention and (2) compare differences in prescribing preferences between consultant vascular surgeons and trainees.Methods and analysisThis cross-sectional survey will evaluate antithrombotic prescribing choices using a discrete choice experiment (DCE) that has been developed and piloted for this study. A list of attributes and levels was generated using a mixed-methods approach. This included an extensive literature review and semistructured interviews with prescribing clinicians. Following final selection of included attributes, specialised software was used to construct a D-efficient design for the DCE questionnaire. The electronic questionnaire will be administered to vascular trainees and consultant surgeons across Australia. These data will be analysed using multinomial logistic regression, treating the decision to prescribe antithrombotic therapy as a function of both the attributes of the two alternatives, as well as characteristics of the respondent. Latent class analysis will be used to explore heterogeneity of responses.Ethics and disseminationEthics approval was obtained from the University of Sydney Human Ethics committee (2023/474). The results of this study will be published in peer-reviewed journals and presented at national vascular surgical conferences. These results will be used to improve understanding how clinicians make prescribing decisions and to inform future strategy to enhance guideline-directed prescribing.
Home-based mobile-guided exercise-based cardiac rehabilitation among patients undergoing transcatheter aortic valve replacement (REHAB-TAVR): protocol for a randomised clinical trial
Authors: Shen Zhiyun , Mi Shouling , Huang Chenxu , Zhou Daxin , Pan Wenzhi , Xu Xiaohua , Lin Ying , Zhang Yuxia 
Published: May 2024

IntroductionTranscatheter aortic valve replacement (TAVR) is a standard treatment for aortic stenosis, particularly in older adults. Reduced exercise capacity and frailty significantly impact outcomes in TAVR patients, yet current management lacks strategies to address these issues. This study aims to assess the effectiveness of home-based mobile-guided exercise-based cardiac rehabilitation in TAVR patients, led by a multidisciplinary team with clear progression milestones.Methods and analysisThe study involves 90 patients aged 60–89 in a single centre who will be randomised to a 3-month novel multidomain exercise intervention or routine care. Outcome assessors will be blinded towards group allocation. The primary outcome is the 6-min walk distance at month 3. The secondary outcomes include the 6-min walk distance at month 6, physical function measured by total Short Physical Performance Battery score and exercise adherence measured by the Exercise Adherence Rating Scale at months 3 and 6. Additional outcome measures, including rehospitalisations, death, handgrip strength, frailty (Fried Criteria and Essential Toolset), cognitive function (Mini-Mental State Examination), quality of life (EuroQol 5-Dimension 5-Level), nutritional status (Mini-Nutritional Assessment), anxiety (General Anxiety Disorder-7), depression (Geriatric Depression Scale), sleep (Pittsburgh Sleep Quality Index), functional capacity (Duke Activity Status Index), clinical indices (body mass index, symptoms, signs, left ventricular ejection fraction (LVEF), N-Terminal Pro-Brain Natriuretic Peptide, etc) and social support (Lubben Social Network Scale-6), along with comprehensive cost analysis, enhance the study’s significance. The study’s findings hold crucial implications for crafting an effective exercise-focused cardiac rehabilitation strategy for TAVR patients. Community implementation not only deepens understanding but also fosters the potential integration of exercise-based cardiac rehabilitation into self-care, promising enhanced patient adherence and overall cardiovascular health management.Ethics and disseminationEthical approval was obtained from the Zhongshan Hospital, Fudan University Ethics Committee (B2022-062R). Results will be disseminated to local stakeholders and the research community through publications and conferences.Trial registration numberNCT05989594
Evaluation of hospital-onset bacteraemia and fungaemia in the USA as a potential healthcare quality measure: a cross-sectional study
Authors: Leekha Surbhi , Robinson Gwen L , Jacob Jesse T , Fridkin Scott , Shane Andi , Sick-Samuels Anna , Milstone Aaron M , Nair Rajeshwari , Perencevich Eli , Puig-Asensio Mireia , Kobayashi Takaaki , Mayer Jeanmarie , Lewis Julia , Bleasdale Susan , Wenzler Eric , Mena Lora Alfredo J , Baghdadi Jonathan , Schrank Gregory M , Wilber Eli , Aldredge Amalia A , Sharp Joseph , Dyer Kelly E , Kendrick Lea , Ambalam Viraj , Borgetti Scott , Carmack Anna , Gushiken Alexis , Patel Ashka , Reddy Sujan , Brown Clayton H , Dantes Raymund B , Harris Anthony D 
Published: May 2024

BackgroundHospital-onset bacteraemia and fungaemia (HOB) is being explored as a surveillance and quality metric. The objectives of the current study were to determine sources and preventability of HOB in hospitalised patients in the USA and to identify factors associated with perceived preventability.MethodsWe conducted a cross-sectional study of HOB events at 10 academic and three community hospitals using structured chart review. HOB was defined as a blood culture on or after hospital day 4 with growth of one or more bacterial or fungal organisms. HOB events were stratified by commensal and non-commensal organisms. Medical resident physicians, infectious disease fellows or infection preventionists reviewed charts to determine HOB source, and infectious disease physicians with training in infection prevention/hospital epidemiology rated preventability from 1 to 6 (1=definitely preventable to 6=definitely not preventable) using a structured guide. Ratings of 1–3 were collectively considered ‘potentially preventable’ and 4–6 ‘potentially not preventable’.ResultsAmong 1789 HOB events with non-commensal organisms, gastrointestinal (including neutropenic translocation) (35%) and endovascular (32%) were the most common sources. Overall, 636/1789 (36%) non-commensal and 238/320 (74%) commensal HOB events were rated potentially preventable. In logistic regression analysis among non-commensal HOB events, events attributed to intravascular catheter-related infection, indwelling urinary catheter-related infection and surgical site infection had higher odds of being rated preventable while events with neutropenia, immunosuppression, gastrointestinal sources, polymicrobial cultures and previous positive blood culture in the same admission had lower odds of being rated preventable, compared with events without those attributes. Of 636 potentially preventable non-commensal HOB events, 47% were endovascular in origin, followed by gastrointestinal, respiratory and urinary sources; approximately 40% of those events would not be captured through existing healthcare-associated infection surveillance.DiscussionFactors identified as associated with higher or lower preventability should be used to guide inclusion, exclusion and risk adjustment for an HOB-related quality metric.
Effect of the non-application of the motorcycle male passenger restriction policy on the risk of homicides in Cali, Colombia
Authors: Mena Jorge , Fandiño-Losada Andrés , Gutiérrez María Isabel 
Published: May 2024

BackgroundRestrictions of male passengers of motorcycles to prevent homicides is a long-standing policy in Cali, Colombia. For some periods of time, the policy was suspended and then put into action again. All these changes were never evaluated and there has been controversy due to the perception of citizens, specifically motorcycle users, that the law was properly implemented in some periods and poorly applied in others. Our aim was to examine the effect of the non-application of the motorcycle male passenger restriction policy on the risk of homicides in Cali, Colombia.MethodsEcologic study conducted using an interrupted time series analysis. The main outcome was the aggregated daily counts of homicides. Secondary outcomes were the aggregated daily counts of homicides using a motorcycle and using motorcycle and firearm. Incidence rate ratios (IRR) were obtained by comparing periods of policy implementation with periods of lack of implementation in autoregressive negative binomial regression models.ResultsThere was an increased risk of homicides when the policy was not implemented (IRR=1.12; 1.05–1.19). There was no effect on the risk of homicides committed in motorcycles (IRR=0.98; 0.88–1.10) and when a motorcycle and firearm were used (IRR=0.99; 0.89–1.10).ConclusionsThe lack of implementation of the ban of motorcycle male passengers was associated with an increased risk of homicides. Our findings support the importance of this policy to prevent homicides in Cali, Colombia. Future work should examine how this policy influences other policies related to prevent homicide and violent risk-related behaviour.
Neighbourhood-level policing as a racialised gendered stressor: multilevel analysis of police stops and preterm birth in Seattle, Washington
Authors: Riley Taylor , Jahn Jaquelyn L , Sharif Mienah Z , Enquobahrie Daniel A , Hajat Anjum 
Published: May 2024

BackgroundMost studies capturing the health effects of police violence focus on directly impacted individuals, but a burgeoning field of study is capturing the indirect, community-level health effects of policing. Few empirical studies have examined neighbourhood-level policing, a contextual and racialised gendered stressor, in relation to preterm birth risk among Black and other racially minoritised people.MethodsWe spatially linked individual birth records (2017–2019) in Seattle, Washington (n=25 909) with geocoded data on police stops for three exposure windows: year before pregnancy, first and second trimester. We fit race-stratified multilevel modified Poisson regression models predicting preterm birth (<37 gestational weeks) across tertiles of neighbourhood stop rates controlling for individual and neighbourhood-level covariates. For the second trimester exposure window, birth was operationalised as a time-to-event outcome using multilevel Cox proportional hazard models.ResultsNeighbourhood stop rates of Black residents was higher compared with White residents, and Black and Asian pregnant people were exposed to the highest median neighbourhood-level stop rates. Black birthing people living in neighbourhoods with more frequent police stops had increased risk of preterm birth across all exposure windows including the year before pregnancy (adjusted risk ratio (aRR): 1.38, 95% CI 1.02 to 1.85), first trimester (aRR:1.74, 95% CI 1.17 to 2.57) and second trimester (aHR: 1.66, 95% CI 1.14 to 2.42). We found null or inverse associations among Asian, Hispanic and White people.ConclusionOur study adds to the growing evidence documenting associations of higher risk of preterm birth with neighbourhood police stops among Black birthing people. These findings suggest that routine police practices are one aspect of structural racism contributing to racialised perinatal health inequities.
Matching in Networks: Structure of the Set of Stable Allocations
Authors: Garces Alejandra , Neme Alejandro , Risma Eliana Pepa 
Published: May 2024

Matching models with contracts have been extensively studied in the last years as a generalization of the classical matching theory. Matching in networks is an even more general model in which firms trade goods via bilateral contracts constituting a supply chain. Hatfield and Kominers ([2012] Matching in networks with bilateral contracts, Am. Econ. J., Microecon. 4(1), 176–208, doi:10.1257/mic.4.1.176) showed that a natural substitutability condition characterizes the maximal domain of firm preferences for which the existence of stable allocations is guaranteed in such a model, if the set of all existent contracts is acyclic. Moreover, they asserted that these conditions are sufficient to obtain a suitable lattice structure for the set of all stable allocations. In this paper, we exhibit an inconsistency in the last point through an example, and introduce an additional condition over firm preferences that allows to recover an appropriate lattice structure.
The Effect of the Proportion of Rubber Components on the Properties of EVA/SBR/BR Foams
Authors: Li Qianxi , Gong Zhou , Wang Xinghuo , Cao Ziwu , Hao Jianxin , Chen Yukun 
Published: May 2024

In actual production processes, pure ethyl vinyl acetate (EVA) foams have a high shrinkage rate, and the foaming matrix is prone to plastic deformation, even causing the collapse of bubbles. This limits the further application of EVA foams. In this study, we incorporated styrene butadiene rubber (SBR) and butadiene rubber (BR) into EVA to improve the mechanical properties and dimensional stability of EVA composite foams without sacrificing their low-density characteristics of low density. We used a melting index meter, rotorless vulcanizing meter and dynamic mechanical analysis (DMA) to characterize the changes in viscosity and energy storage modulus of the composite matrix. Scanning electron microscopy (SEM) was used to study the microscopic morphology of foams. The mechanical properties test results showed that the addition of SBR reduced the density of EVA/SBR/BR composite foams, and the addition of BR improved the mechanical properties and dimensional stability of the foams. By combining the advantages of both, the density of products is comparable to pure EVA, the tensile strength and the compressive strength are increased by 11% and 6.3% relative to pure EVA, respectively.
Effects of Clinical Covariates on Serum miRNA Expression among Women without Ovarian Cancer
Authors: Wollborn Laura , Webber James W. , Alimena Stephanie , Mishra Sudhanshu , Sussman Chad B. , Comrie Cameron E. , Packard Daniel G. , Williams Marta , Russell Trinity , Fendler Wojciech , Chowdhury Dipanjan , Elias Kevin M. 
Published: May 2024

Abstract

Background:
Serum miRNAs are potential biomarkers for ovarian cancer; however, many factors may influence miRNA expression. To understand potential confounders in miRNA analysis, we examined how sociodemographic factors and comorbidities, including known ovarian cancer risk factors, influence serum miRNA levels in women without ovarian cancer.

Methods:
Data from 1,576 women from the Mass General Brigham Biobank collected between 2012 and 2019, excluding subjects previously or subsequently diagnosed with ovarian cancer, were examined. Using a focused panel of 179 miRNA probes optimized for serum profiling, miRNA expression was measured by flow cytometry using the Abcam FirePlex assay and correlated with subjects’ electronic medical records.

Results:
The study population broadly reflected the New England population. The median age of subjects was 49 years, 34% were current or prior smokers, 33% were obese (body mass index &gt; 30 kg/m2), 49% were postmenopausal, and 11% had undergone prior bilateral oophorectomy. Significant differences in miRNA expression were observed among ovarian risk factors such as age, obesity, menopause, BRCA1 or BRCA2 germline mutations, or existence of breast cancer in family history. Additionally, miRNA expression was significantly altered by prior bilateral oophorectomy, hypertension, and hypercholesterolemia. Other variables, such as smoking; parity; age at menarche; hormonal replacement therapy; oral contraception; breast, endometrial, or colon cancer; and diabetes, were not associated with significant changes in the panel when corrected for multiple testing.

Conclusions:
Serum miRNA expression patterns are significantly affected by patient demographics, exposure history, and medical comorbidities.

Impact:
Understanding confounders in serum miRNA expression is important for refining clinical assays for cancer screening.
Association of Urinary Biomarkers of Tobacco Exposure with Lung Cancer Risk in African American and White Cigarette Smokers in the Southern Community Cohort Study
Authors: Murphy Sharon E. , Guillermo Cherie , Thomson Nicole M. , Carmella Steven G. , Wittmann Milo , Aldrich Melinda C. , Cai Qiuyin , Sullivan Shannon M. , Stram Daniel O. , Le Marchand Loïc , Hecht Stephen S. , Blot William J. , Park S. Lani 
Published: May 2024

Abstract

Background:
After accounting for smoking history, lung cancer incidence is greater in African Americans than Whites. In the multiethnic cohort, total nicotine equivalents (TNE) are higher in African Americans than Whites at similar reported cigarettes per day. Greater toxicant uptake per cigarette may contribute to the greater lung cancer risk of African Americans.

Methods:
In a nested case–control lung cancer study within the Southern Community Cohort, smoking-related biomarkers were measured in 259 cases and 503 controls (40% White; 56% African American). TNE, the trans-3-hydroxycotinine/cotinine ratio, 4-(methylnitrosamino)-1–3-(pyridyl)-1-butanol (NNAL), mercapturic acid metabolites of volatile organic compounds, phenanthrene metabolites, cadmium (Cd), and (Z)-7-(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopenyl]hept-5-enoic acid were quantified in urine. Unconditional logistic regression was used to estimate the ORs and 95% confidence intervals (CI) for each biomarker and lung cancer risk.

Results:
TNE, NNAL, and Cd were higher in cases than controls (adjusted for age, race, sex, body mass index, and cigarettes per day). Among cases, these levels were higher in African Americans compared with Whites. After accounting for age, sex, body mass index, and pack-years, a one-SD increase in log-TNE (OR = 1.30; 95% CI, 1.10–1.54) and log-NNAL (OR = 1.27; 95% CI, 1.03–1.58 with TNE adjustment) was associated with lung cancer risk. In this study, in which NNAL concentration is relatively high, the association for log-TNE was attenuated after adjustment for log-NNAL.

Conclusions:
Smoking-related biomarkers provide additional information for lung cancer risk in smokers beyond smoking pack-years.

Impact:
Urinary NNAL, TNE, and Cd concentrations in current smokers, particularly African American smokers, may be useful for predicting lung cancer risk.