bluuebunny/crossref_metadata_2025_split huggingface dataset:
IGFBP-2 expression, angiogenesis and pseudopalisades in glioblastoma
Authors: Pažanin Leo , Vučić Majda , Čupić Hrvoje , Plavec Davor , Krušlin Božo 
Published: September 2011

Abstract
Glioblastoma is the most frequent, the most malignant and the best vascularised primary brain tumor. Substantial evidence suggests that IGFBP-2 (insulin-like growth factor binding protein) may play a significant role in the development and progression of various types of cancer, including the anaplastic progression of astroglial tumors. The correlation of IGFBP-2 and VEGF over-expression in diffuse gliomas and strong IGFBP-2 immunostaining and co-expression with VEGF in the cells of pseudopalisading necrosis suggests the induction of IGFBP-2 expression by hypoxia and/or possible involvement of its protein product in angiogenesis. The aim of this study was to analyze the expression of IGFBP-2 and the relationship between the IGFBP-2 expression, extent of bizarre angiogenesis and the presence of pseudopalisades. The prognostic impact of these variables was estimated, as well. Our results revealed that most glioblastoma (75%) express IGFBP2 and that IGFBP2 expression was associated with the presence of pseudopalisading necrosis as well as extensive bizarre angiogenesis. IGFBP-2 immunoreactivity in more than 5% of tumor cells and the presence of pseudopalisading necrosis were prognostically significant in univariate analysis (p=0.034) while in multivariate analysis only a patient’s age and the presence of pseudopalisades remained statistically significant (p=0.004). The results of our study showed the association of IGFBP-2 expression in glioblastoma with pseudopalisades and bizarre angiogenesis thus confirming on morphological grounds presumed induction of this gene under hypoxic conditions and its possible role in angiogenesis.
Development of prefrontal layer III pyramidal neurons in infants with Down syndrome
Authors: Vukšić Mario , Petanjek Zdravko , Kostović Ivica 
Published: September 2011

Abstract
We quantitatively analyzed the dendritic and dendritic spine development on basal and oblique dendrites of large layer IIIc pyramidal neurons of the prospective prefrontal area 9 in the brains of three infants with Down syndrome (DS) and five age-matched-controls over the period from 32 weeks postconception to the 7th postnatal month. By using Neurolucida 3.1 software on rapid Golgi impregnated slices, 9–10 neurons were three-dimensionally reconstructed. There were no significant differences in the pattern of the dendritic and spine development between the basal and apical oblique dendrites. The DS subjects did not depart significantly from the developmental curve of the control subjects. Our data showed that large and significant segment outgrowth, in parallel with dendritic elongation occurred during a limited period of time, between 36 weeks postconception and the first postnatal month. Dendritic spines appeared at the time of birth and their density continued to increase up to the age of 7 months. During the first postnatal month long thin spines and filopodia-like protrusions predominated, but the spines later changed their morphology to a more mature form. No differences in the spine morphology were qualitatively observed between the DS infants and the age matched controls. This data suggests that intensive formation of cortical circuitry occurs on large layer IIIc pyramidal neurons during perinatal period and is not disturbed in DS infants. Consequently, this could be a biological potential to mitigate psychomotor impairment in DS patient.
Non-invasive protein analysis in the first dysferlinopathy Croatian families
Authors: Milić Astrid , Malnar Martina , Canki-Klain Nina 
Published: September 2011

Abstract
Mutations in human dysferlin (DYSF) gene cause both limb girdle muscular dystrophy type 2B (LGMD2B) and Miyoshi myopathy (MM), also named dysferlinopathy. They are autosomal recessive muscular dystrophies characterized by degeneration and weakness of proximal and/or distal limb girdle muscles caused by partial or complete absence of a sarcolemmal protein dysferlin. The size and large mutational spectrum of DYSF impose a multistep diagnosis strategy before gene analysis. Here we report the first three patients from two unrelated Croatian families in which diagnosis of dysferlinopathy was suggested on the basis of clinical picture, family history and linkage analysis. In order to confirm the presumed diagnosis, we performed a blood-based assay in which dysferlin expression is screened in blood monocytes. All three tested patients showed complete absence of dysferlin expression, giving strong evidence of dysferlinopathy that was recently confirmed by mutation analysis. In conclusion, we would suggest the presented diagnostic strategy as a reliable and non-invasive method to be used as an alternative to muscle tissue protein analysis in routine diagnostics of dysferlinopathies, prior to the more complex and demanding search for causative DYSF mutations. This non-aggressive approach seems especially useful in situation in which multiplex Western blot (WB) analysis of different muscular dystrophy proteins on muscle sample is not available.
Giant cavernoma of the skull and skeletal-extraskeletal angiomatosis associated with paraproteinemia
Authors: Šarac Helena , Hajnšek Sanja , Bašić Silvio , Telarović Srđana , Markeljević Jasenka , Vukić Miroslav , Radoš Marko , Bošnjak-Pašić Marija , Žarković Kamelija , Hof Patrick , Šimić Goran 
Published: September 2011

Abstract
Skeletal-extraskeletal angiomatosis is defined as a benign vascular proliferation affecting the medullar cavity of the bone and at least one other type of tissue, including skin, subcutaneous tissue, viscera, muscle, or synovium, and which does not spread to avascular tissue such as cartilage. Primary hemangiomas/cavernous hemangiomas (cavernomas) are exceedingly rare in the skull, accounting for 0.2% of all osseous neoplasms and are usually located in frontal and parietal bones. The authors present the case of a 66-year-old man who was admitted with right-side hemiparesis. MRI revealed a destructive bone lesion of the left frontal bone. Digital subtraction angiography of the brain did not reveal pathological vascularization, but a minor submucous hemangioma was seen in the nasal airway. Urine test for Bence-Jones proteins was positive for IgG λ light chain. Bone marrow aspiration and CSF analysis revealed no evidence of systemic myelomatosis suggesting a monoclonal gammopathy of undetermined significance. A highly vascular tumor was surgically removed. The histopathology verified cavernous hemangioma of the skull and the nasal submucous hemangioma. We discuss the diagnostic procedure, possible pathophysiological mechanisms and treatment implementation. It is possible that immunoglobulins from monoclonal gammopathies have an etiologic role in the development of the bone and skin changes in older patients, as an acquired condition, by producing a vascular injury that could lead to the multiple hemangiomas in skeletal-extraskeletal angiomatosis. To prevent misdiagnosis with lesions of other origins, multiple lesions of the head must be resected and histopathologically verified. In conclusion, to the best of our knowledge, this is the first case of giant cavernous hemangioma of the skull associated with paraproteinemia and skeletalextraskeletal angiomatosis limited to the head.
Integrated design of observer based fault detection for a class of uncertain nonlinear systems
Authors: Chen Wei , Khan Abdul , Abid Muhammmad , Ding Steven 
Published: September 2011

Integrated design of observer based fault detection for a class of uncertain nonlinear systems
Integrated design of observer based Fault Detection (FD) for a class of uncertain nonlinear systems with Lipschitz nonlinearities is studied. In the context of norm based residual evaluation, the residual generator and evaluator are designed together in an integrated form, and, based on it, a trade-off FD system is finally achieved in the sense that, for a given Fault Detection Rate (FDR), the False Alarm Rate (FAR) is minimized. A numerical example is given to illustrate the effectiveness of the proposed design method.
Performance evaluation based fault tolerant control with actuator saturation avoidance
Authors: Boussaid Boumedyen , Aubrun Christophe , Abdelkrim Mohamed , Gayed Mohamed 
Published: September 2011

Performance evaluation based fault tolerant control with actuator saturation avoidanceIn this paper, a new approach regarding a reconfigured system is proposed to improve the performance of an active fault tolerant control system. The system performance is evaluated with an intelligent index of performance. The reconfiguration mechanism is based on a model predictive controller and reference trajectory management techniques. When an actuator fault occurs in the system, a new degraded reference trajectory is generated and the controller calculates new admissible controls. A constraint set and cost function are established to avoid actuator saturation and reduce the control energy spent in closed loop dynamics. The effectiveness of the proposed method is illustrated using a hydrothermal system subject to actuator faults and constraints on actuator dynamic ranges.
A sign preserving mixed finite element approximation for contact problems
Authors: Hild Patrick 
Published: September 2011

A sign preserving mixed finite element approximation for contact problemsThis paper is concerned with the frictionless unilateral contact problem (i.e., a Signorini problem with the elasticity operator). We consider a mixed finite element method in which the unknowns are the displacement field and the contact pressure. The particularity of the method is that it furnishes a normal displacement field and a contact pressure satisfying the sign conditions of the continuous problem. Thea priorierror analysis of the method is closely linked with the study of a specific positivity preserving operator of averaging type which differs from the one of Chen and Nochetto. We show that this method is convergent and satisfies the samea priorierror estimates as the standard approach in which the approximated contact pressure satisfies only a weak sign condition. Finally we perform some computations to illustrate and compare the sign preserving method with the standard approach.
Motion representations for the Lafferriere-Sussmann algorithm for nilpotent control systems
Authors: Dulęba Ignacy , Jagodziñski Jacek 
Published: September 2011

Motion representations for the Lafferriere-Sussmann algorithm for nilpotent control systemsIn this paper, an extension of the Lafferriere-Sussmann algorithm of motion planning for driftless nilpotent control systems is analyzed. It is aimed at making more numerous admissible representations of motion in the algorithm. The representations allow designing a shape of trajectories joining the initial and final configuration of the motion planning task. This feature is especially important in motion planning in a cluttered environment. Some natural functions are introduced to measure the shape of a trajectory in the configuration space and to evaluate trajectories corresponding to different representations of motion.
An operational Haar wavelet method for solving fractional Volterra integral equations
Authors: Saeedi Habibollah , Mollahasani Nasibeh , Moghadam Mahmoud , Chuev Gennady 
Published: September 2011

An operational Haar wavelet method for solving fractional Volterra integral equationsA Haar wavelet operational matrix is applied to fractional integration, which has not been undertaken before. The Haar wavelet approximating method is used to reduce the fractional Volterra and Abel integral equations to a system of algebraic equations. A global error bound is estimated and some numerical examples with smooth, nonsmooth, and singular solutions are considered to demonstrate the validity and applicability of the developed method.
Development of microsatellite markers for the medicinal plant Isodon rubescens (Lamiaceae) and related species
Authors: Harris Eric S. J. , Klooster Matthew R. 
Published: September 2011

• Premise of the study: Microsatellite markers were developed for the medicinal plant Isodon rubescens to investigate genetic variability of the species and, in future studies, to assess its relation to the content of pharmacologically active chemicals produced by the plant.• Methods and Results: Eleven primer pairs were identified and tested in multiple populations of I. rubescens and related species (I. henryi, I. enanderianus, I. lophanthoides) from the People's Republic of China. The primers amplified dinucleotide repeats and had between two and 12 alleles per locus in a given population.• Conclusions: These microsatellites will be useful for understanding patterns of phytochemical variation in I. rubescens and have the potential to be applied to research on evolutionary processes in other species of the genus Isodon.
Uretero-Ileal Anastomosis in Orthotopic Neobladder: Antireflux versus Direct Techinique
Authors: Teppa Alessandro , Rosini Roberto , Tonini Gerolamo , Tosana Michelangelo 
Published: September 2011

Objectives We report on the long-term functional results of the orthotopic VIP neobladder and compare the outcome of the antireflux technique for ureteral implantation versus direct anastomosis. Patients and MethOds. Between 1998 and 2009, 84 patients underwent cystoprostatectomy and orthotopic VIP neobladder for invasive bladder carcinoma. 96 renal units were reimplanted using the Enine-Ghoneim antirefluxing technique (group 1). The direct Nesbit end-to-side technique for ureteral reimplantation was applied in 72 renal units (group 2). The mean follow-up period was 54 months (range, 10–154 months). Results Of the 96 renal units who underwent the Enine-Ghoneim technique, 12 (12.5%) had uretero-ileal anastomotic stricture and 4 (4.1%) had reflux. Of the 72 renal units who underwent direct anastomosis, 11 (15.2%) patients had reflux, 2 (2.7%) had uretero-ileal anastomotic stricture. The incidence of stricture formation in the Enine-Ghoneim technique is significantly higher than direct anastomosis. The incidence of reflux in preoperatively dilated ureters was significantly higher in direct ureteral anastomosis than antireflux technique. The incidence of stone formation, renal scaring and pyelonephritis was comparable in both groups. Conclusions Direct uretero-ileal anastomosis in orthotopic bladder replacement is more reasonable than the Enine-Ghoneim antireflux technique in non-dilated ureters. The benefit of the antireflux technique has been overestimated despite the frequency of stricture formation.
Negligible soil erosion in a burned mountain watershed, Canadian Rockies: field and modelling investigations considering the role of duff
Authors: Martin Y.E. , Johnson E.A. , Gallaway J.M. , Chaikina O. 
Published: September 2011

ABSTRACTIncreased soil erosion in immediate post‐wildfire years has been well documented in the literature, but many unanswered questions remain about the factors controlling erosional responses in different regional settings. The field site for the present study was located in a closed canopy, subalpine forest in Kootenay National Park, British Columbia that was subjected to a high‐intensity crown fire in the summer of 2003. Low soil erosion values were documented at the study site in the years immediately following the 2003 wildfire, with estimates ranging from approximately 10‐1up to 100 t ha‐1. Following the wildfire, notable duff coverage (the duff layer is the combined fermentation and humus soil organic layers) remained above the mineral soil. This finding supports earlier studies documenting only partial duff consumption by high‐intensity wildfires in the boreal forest of Canada. It is postulated that remnant duff coverage after many high‐intensity wildfires impacts the hydrological and soil erosional response to rainstorm events in post‐wildfire years. In particular, duff provides detention storage for infiltrating rainfall and, therefore, may inhibit the generation of overland flow. Furthermore, duff also provides a physical barrier to soil erosion. The Green–Ampt model of rainfall infiltration is employed to better assess how interactions between rainfall duration/intensity and soil/duff properties affect hydrological response and the generation of overland flow. Model results show that duff provides an effective zone for detention storage and that duff accommodates all rainfall intensities to which it was subjected without the occurrence of surface ponding. In addition, the penetration of the wetting front is relatively slow in duff due to its high porosity and water storage potential. Copyright © 2011 John Wiley & Sons, Ltd.
Prospects for pluripotent stem cell therapies: Into the clinic and back to the bench
Authors: Grabel Laura 
Published: September 2011

AbstractPluripotent stem cells, embryonic stem (ES) cells and induced pluripotent stem (iPS) cells, both hold great promise for the understanding and treatment of disease. They can be used for drug testing, as in vitro models for human disease progression, and for transplantation therapies. Research in this area has been influenced by the ever‐changing political landscape, particularly in the United States. In this review, we discuss the prospects for clinical application using pluripotent cells, focusing on an evaluation of iPS cell potential, the continuing concern of tumor formation, and a summary of in vitro differentiation protocols and animal models used. We also describe the current clinical trials underway in the United States, as well as the ups and downs of funding for ES cell work. J. Cell. Biochem. 113: 381–387, 2012. © 2011 Wiley Periodicals, Inc.
Targeting AMPK in the treatment of malignancies
Authors: Vakana Eliza , Altman Jessica K. , Platanias Leonidas C. 
Published: September 2011

AbstractThe AMPK pathway is a metabolic stress‐related and energy censor pathway which plays important regulatory roles in normal and malignant cells. This cellular cascade controls generation of signals for initiation of mRNA translation via the mTOR pathway and exhibits regulatory roles on the initiation of autophagy. AMPK activators have been shown to suppress mTOR activity and to negatively control malignant transformation and cell proliferation of diverse malignant cell types. Such properties of AMPK inducers have generated substantial interest for the use of AMPK targeting compounds as antineoplastic agents and have provoked extensive research efforts to better define and classify the mechanisms controlling AMPK activity and its functional consequences in malignant cells. J. Cell. Biochem. 113: 404–409, 2012. © 2011 Wiley Periodicals, Inc.
Inquisitio validus Index Medicus: A simple method of validating MEDLINE systematic review searches
Authors: Sampson Margaret , McGowan Jessie 
Published: September 2011

We offer a new method of validation for the effectiveness of MEDLINE searches used in systematic reviews, the Inquisitio Validus Index Medicus. Validation is essential to ensure that relevant studies are not missed by the MEDLINE search strategy.MethodsTo demonstrate the validation method, a sample of six updated Cochrane reviews with comprehensive searches was used. The MEDLINE searches of both the original and updated reviews were tested to determine the percent of eligible MEDLINE‐indexed studies retrieved by the search (recall).ResultsThe validation method was robust and was able to demonstrate that the retrieval of relevant studies from MEDLINE was sub‐optimal. The approach to revising searches in our sample appeared unsystematic. Some poorly performing searches were used unchanged in the updates, and of the two amended strategies, one performed worse than the original when tested against studies included in the original, while the other improved recall.ConclusionThere is a clear need for search validation. Using this validation method can determine whether the search of the main database performs adequately or needs to be revised to improve recall, allowing the searcher an opportunity to improve their search strategy. Validation of the search is recommended for systematic reviews, where the intent is to identify all relevant studies. Copyright © 2011 John Wiley & Sons, Ltd.
Phased array antenna with crossed dipole antenna for mobile satellite communications
Authors: Hasegawa Shohei , Yasuzumi Takenori , Kazama Yasuhiro , Hashimoto Osamu 
Published: September 2011

AbstractIn this article, we propose a phased array antenna which uses a crossed dipole antenna with a reflector as an element antenna.The element antenna has conical radiation pattern which is useful for a satellite communication mobile station antenna. The element antenna radiates linearly polarized wave. Both simulation with electromagnetic simulator and experiment are performed in 19‐element array antenna for the beam scanning characteristics. From measured results, the obtained antenna gain is more than 10 dBi from 30° to 60°. It is shown that the characteristics of the array antenna are effective to use for a satellite communications. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 2805–2809, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26424
Metamaterial focusing device for microwave hyperthermia
Authors: Velázquez‐Ahumada María C. , Freire Manuel J. , Marqués Ricardo 
Published: September 2011

AbstractThis work shows a microwave focusing device based on metamaterials which can find application in hyperthermia of tumors. The device consists of an array of split‐ring resonators placed between two parallel metal plates. Both the fields and the temperature distribution are numerically obtained in a model of breast tissue and a tumor by modeling the device as a homogeneous uniaxial slab of negative permeability placed between the two metal plates. The theoretical predictions about the field distribution have been experimentally checked by measuring the field produced by the fabricated device inside a phantom resembling the breast tissue. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2868–2872, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26434
Continuity and discontinuity of depressed mood from late adolescence to young adulthood: The mediating and stabilizing roles of young adults’ socioeconomic attainment
Authors: Wickrama K.A.S. , Conger Rand D. , Lorenz Federick O. , Martin Monica 
Published: September 2011

ABSTRACTUsing prospective, longitudinal data from 467 youth over a 13‐year period (late adolescence and young adulthood), the present study investigates three research questions: (1) to what extent do elevations in depressed mood continue (homotypic continuity) from adolescence to young adulthood, (2) to what extent do young adults’ socioeconomic attainments and failures sustain the depressed mood from adolescence to young adulthood, and (3) to what extent do young adults’ socioeconomic attainments or failures mediate the continuity and discontinuity of depressive symptoms across this period? The results from our structural equation modeling (SEM) analyses suggest that continuity of depressive symptoms from late adolescence to young adulthood is mediated in part by economic and work achievements or failures of young adults after controlling for adolescent conduct disorder/antisocial behavior, parents’ psychopathology and family adversity. Additionally, the results indicate that the continuity of depressed mood across the early life course is conditioned (stabilized or disrupted) by young adult socioeconomic achievements or failures.