bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Regioselective Hydroaminomethylation of Terminal Olefins to Linear Amines Using Rh Complexes with a Tetrabi Phosphorus Ligand
Authors: Liu Guodu , Huang Kexuan , Cai Chaoxian , Cao Bonan , Chang Mingxin , Wu Wenjun , Zhang Xumu 
Published: November 2011

AbstractA highly regioselective hydroaminomethylation of terminal olefins catalyzed by Rh complexes with 2, 2′, 6, 6′‐tetrakis ((diphenylphosphino)methyl)‐1, 1′‐biphenyl (Tetrabi) ligand has been developed. Up to 99 % amine selectivity, 168 linear/branched amine product ratio (n/i), and 97.4 % linear amine yield has been obtained at a substrate/rhodium precursor ratio (S/Rh) of 1000 with this methodology. The turnover number was achieved 6930 at 10000 S/Rh ratio, and the n/i can reach up to >525. Several different olefins and secondary amines have been applied successfully with high chemoselectivity (99 %), yield (>98 %), and regioselectivity (>120).
Resistance of wood pellets to low airflow
Authors: Yazdanpanah F. , Lau A. , Sokhansanj S. , Lim C. J. , Bi X. , Melin S. 
Published: November 2011

AbstractThe pressure drop versus low airflow from 0.000117 to 0.1 m/s was measured across a fixed bed of wood pellets. Wood pellets were on average 6.2 mm in diameter and 12 mm in length. The moisture content of wood pellets ranged from 2.8% to 8.1%. Four equations, Darcy, Shedd, Hukill and Ergun representing flow versus static pressure drop for bulk granules were fitted to the experimental data. At airflows below 0.01 m/s, the predicted pressure drops using all four equations deviated from experimental data. This deviation was the largest for the Darcy equation and the smallest for Ergun equation. © 2011 Canadian Society for Chemical Engineering
Power and Perceived Expressed Emotion of Voices: Their Impact on Depression and Suicidal Thinking in Those Who Hear Voices
Authors: Connor Charlotte , Birchwood Max 
Published: November 2011

Considerable focus has been given to the interpersonal nature of the voice‐hearing relationship and how appraisals about voices may be linked with distress and depression (the ‘cognitive model’). Research hitherto has focused on appraisals of voice power, but the supportive and affiliative quality of voices, which may act to mitigate distress, is not understood. We explored appraisals of voices' power and emotional support to determine their significance in predicting depression and suicidal thought. We adapted the concept of expressed emotion (EE) and applied it to measure voice hearers' perception of the relationship with their voice(s). In a sample of 74 voice hearers, 55.4% were moderately depressed. Seventy‐eight who rated their voices as high in both power and EE had a large and significant elevation in depression, suggesting that co‐occurrence of these appraisals impacts on depression. Analysis of the relationship between power and EE revealed that many voices perceived as low in power were, nevertheless, perceived as high in EE. Those rating their voices as emotionally supportive showed the lowest levels of depression and suicidal thinking. These findings highlight the protective role that the supportive dimension of the voice/voice‐hearer relationship may have. Copyright © 2011 John Wiley & Sons, Ltd.Key Practitioner MessageAppraisals of social rank and EE impact on the depressive and suicidal status of voice‐hearers.The emotionally supportive dimension of the voice‐hearing relationship may have a protective role in the affective response of voice hearers.Therapeutic interventions should consider the emotionally supportive needs of voice‐hearers,
Co‐simulation‐based modeling and performance analysis of hybrid fiber–wireless links
Authors: Chettat H. , Simohamed L. M. , Algani C. , Polleux J.‐L. , Billabert A.‐L. , Yalaoui A. 
Published: November 2011

SUMMARYWe present a new approach for the performance analysis of hybrid fiber/wireless communication systems. This approach is based on a co‐simulation using two types of dedicated software: the first is used for RF/wireless systems whereas the second is devoted to optical communication systems. The proposed method enables simultaneous simulation of all elements of the radio‐over‐fiber link with accurate modeling. A low‐cost wireless local area network over a fiber distribution system is implemented in order to validate the results experimentally. Simulation results are in good agreement with experimental measurements in terms of EVM evolution for different link element configurations. Copyright © 2011 John Wiley & Sons, Ltd.
Bandwidth borrowing‐based QoS approach for adaptive call admission control in multiclass traffic wireless cellular networks
Authors: Khanjari Sharifa Al , Arafeh Bassel , Day Khaled , Alzeidi Nasser 
Published: November 2011

SUMMARYThis paper proposes a QoS approach for an adaptive call admission control (CAC) scheme for multiclass service wireless cellular networks. The QoS of the proposed CAC scheme is achieved through call bandwidth borrowing and call preemption techniques according to the priorities of the traffic classes, using complete sharing of the available bandwidth. The CAC scheme maintains QoS in each class to avoid performance deterioration through mechanisms for call bandwidth degradation, and call bandwidth upgrading based on min–max and max–min policies for fair resource deallocation and reallocation, respectively. The proposed adaptive CAC scheme utilizes a measurement‐based online monitoring approach of the system performance, and a prediction model to determine the amount of bandwidth to be borrowed from calls, or the amount of bandwidth to be returned to calls. The simulation‐based performance evaluation of the proposed adaptive CAC scheme shows the strength and effectiveness of our proposed scheme. Copyright © 2011 John Wiley & Sons, Ltd.
Intralake training set of fossil Cladocera for paleohydrological inferences: evidence for multicentennial drought during the Medieval Climate Anomaly
Authors: Nevalainen Liisa , Luoto Tomi P. 
Published: November 2011

ABSTRACTWe investigated an intralake surface sediment data set for fossil Cladocera from Lake Pieni‐Kauro, eastern Finland, with an objective to develop a paleohydrological inference model for lake level reconstructions. The Cladocera assemblages showed high heterogeneity among the sampling sites according to the water depth gradient, thus enabling the construction of a quantitative inference model for water level reconstructions. The strongest model was developed using weighted averaging with classical deshrinking regression. This model had a jackknifed coefficient of determination of 0.79 and a root mean squared error of prediction of 0.79 m. We tested the performance of the model on previously available Cladocera stratigraphy and Cladocera‐based and chironomid‐based lake level reconstructions from Lake Iso Lehmälampi, southern Finland. The lake level reconstructions, based on different proxies and independent inference models, showed high levels of similarity, indicating a period of lower water table during the Medieval Climate Anomaly around 1000  ad. The results suggest that the applicability of intralake paleohydrological models may not be regionally restricted when applied to similar lake types and, therefore, provide an alternative perspective on paleolimnological training set design and paleoclimatological inferences. Copyright © 2011 John Wiley & Sons, Ltd.
Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis
Authors: Dorhoi Anca , Nouailles Geraldine , Jörg Sabine , Hagens Kristine , Heinemann Ellen , Pradl Lydia , Oberbeck‐Müller Dagmar , Duque‐Correa Maria Adelaida , Reece Stephen T. , Ruland Jürgen , Brosch Roland , Tschopp Jürg , Gross Olaf , Kaufmann Stefan H. E. 
Published: November 2011

AbstractAs a hallmark of tuberculosis (TB), Mycobacterium tuberculosis (MTB) induces granulomatous lung lesions and systemic inflammatory responses during active disease. Molecular regulation of inflammation is associated with inflammasome assembly. We determined the extent to which MTB triggers inflammasome activation and how this impacts on the severity of TB in a mouse model. MTB stimulated release of mature IL‐1β in macrophages while attenuated M. bovis BCG failed to do so. Tubercle bacilli specifically activated the NLRP3 inflammasome and this propensity was strictly controlled by the virulence‐associated RD1 locus of MTB. However, Nlrp3‐deficient mice controlled pulmonary TB, a feature correlated with NLRP3‐independent production of IL‐1β in infected lungs. Our studies demonstrate that MTB activates the NLRP3 inflammasome in macrophages in an ESX‐1‐dependent manner. However, during TB, MTB promotes NLRP3‐ and caspase‐1‐independent IL‐1β release in myeloid cells recruited to lung parenchyma and thus overcomes NLRP3 deficiency in vivo in experimental models.
Developmental regulation of Th17‐cell capacity in human neonates
Authors: Black Allison , Bhaumik Suniti , Kirkman Richard L. , Weaver Casey T. , Randolph David A. 
Published: November 2011

AbstractHuman neonates are at significantly greater risk of serious infection than immunocompetent adults. In particular, very low birth weight infants in the neonatal intensive care nursery are at high risk of developing life‐threatening bacterial and fungal infections. Recent studies have identified Th17 cells as critical mediators of immunity to bacterial and fungal infections at epithelial barriers. Little is known, however, about the ontogeny of Th17‐cell responses in humans. The frequency of serious bacterial infections in preterm infants and the importance of Th17 cells in providing protection against such infections in animal studies prompted us to study Th17‐cell development in human neonates. Naïve CD4+ T cells from extremely preterm infants, term infants, and adults were assayed for their capacity to develop into Th17 effector cells. Surprisingly, Th17‐cell capacity was inversely related to developmental age. Neonates expressed higher levels of IL‐23R, RORγt, and STAT3 prior to activation and showed a significant Th17‐cell bias after activation. In contrast, adult cells expressed more TBX21 with a corresponding Th1‐cell bias. CD161 expression on Th17‐cell precursors was also developmentally regulated. Our results suggest there is significant developmental regulation of CD4+ effector lineages with a strong bias toward Th17‐cell development early in life.
Anti IL‐17A therapy inhibits bone loss in TNF‐α‐mediated murine arthritis by modulation of the T‐cell balance
Authors: Zwerina Karin , Koenders Marije , Hueber Axel , Marijnissen Renoud J. , Baum Wolfgang , Heiland Gisela Ruiz , Zaiss Mario , Mclnnes Iain , Joosten Leo , van den Berg Wim , Zwerina Jochen , Schett Georg 
Published: November 2011

AbstractTumour necrosis factor alpha (TNF‐α) is a major inducer for inflammation and bone loss. Here, we investigated whether interleukin (IL)‐17 plays a role in TNF‐α‐mediated inflammation and bone resorption. Human TNF‐α transgenic (hTNFtg) mice were treated with a neutralizing anti‐IL‐17A antibody and assessed for inflammation, cartilage and bone damage. T‐cell transcription factors and lymphokine patterns were measured in the LNs. IL‐17A inhibition in the absence of IL‐1 was also evaluated by treating hTNFtg/IL‐1−/− mice with an IL‐17A neutralizing antibody. IL‐17A neutralization had only minor effects on TNF‐α‐induced inflammation but effectively reduced local and systemic bone loss by blocking osteoclast differentiation in vivo. Effects were based on a shift to bone‐protective T‐cell responses such as enhanced Th2 differentiation, IL‐4 and IL‐12 expression and Treg cell numbers. Whereas inflammation in hTNFtg/IL‐1−/− mice was highly sensitive to IL‐17A blockade, no shift in the T‐cell lineages and no additional benefit on bone mass were observed in response to IL‐17A neutralization. We thus conclude that IL‐17A is a key mediator of TNF‐α‐induced bone loss by closely interacting with IL‐1 in blocking bone protective T‐cell responses.
Type‐I IFN drives the differentiation of short‐lived effector CD8+ T cells in vivo
Authors: Wiesel Melanie , Crouse Josh , Bedenikovic Gregor , Sutherland Andrew , Joller Nicole , Oxenius Annette 
Published: November 2011

AbstractTwo subsets of CD8+ T cells are generated early during an immune response; one of these subsets forms the memory pool, known as memory precursor effector cells (MPECs), identified by high expression of CD127 and low expression of KLRG1, whereas the other subset forms short‐lived effector cells (SLECs) identified by low expression of CD127 and high expression of KLRG1. Here, we studied in vivo the role of type‐I IFN in this fate decision. We found that under priming conditions dominated by type‐I IFN, as observed in lymphocytic choriomeningitis virus (LCMV) infection, type‐I IFN signaling directly impacted the regulation of T‐bet and thus the early fate decision of CD8+ T cells. In the absence of type‐I IFN signaling, CD8+ T cells failed to form SLECs but could form MPECs that give rise to functional memory CD8+ T cells. Together, these findings identify type‐I IFN as an important factor driving SLEC differentiation and thus instructing the early division between the effector and memory precursor CD8+ T‐cell pool.
Ba6P12N17O9Br3 – A Column‐Type Phosphate Structure Solved from Single‐Nanocrystal Data Obtained by Automated Electron Diffraction Tomography
Authors: Mugnaioli Enrico , Sedlmaier Stefan J. , Oeckler Oliver , Kolb Ute , Schnick Wolfgang 
Published: November 2011

AbstractOxonitridophosphate Ba6P12N17O9Br3 was synthesized by heating a multicomponent mixture of BaBr2, BaS, phosphoryl triamide and thiophosphoryl triamide in an evacuated and sealed silica‐glass ampoule to 750 °C. Ba6P12N17O9Br3 was obtained as the main product as a nanocrystalline powder. The crystal structure was determined ab initio on the basis of electron diffraction data acquired from a single needle‐shaped nanocrystal by automated diffraction tomography. Ba6P12N17O9Br3 crystallizes in the hexagonal space group P63/m (no. 176) with unit cell parameters a = 14.654(19), c = 8.255(9) Å and Z = 2. Its structure includes triangular, column‐shaped anions of ∞1{(P12N17O9)9–}, which are built from vertex‐sharing P(O,N)4 tetrahedra with 3‐rings and three‐coordinate nitrogen atoms. The 1D anions are separated by Ba2+ and Br– ions, which are arranged in channels parallel to the phosphate anions along [001]. The Ba2+ ions are eight‐ and nine‐coordinated by Br– and O/N atoms, respectively.
Ruthenium‐Catalyzed Regioselective Cyclization of Aromatic Ketones with Alkynes: An Efficient Route to Indenols and Benzofulvenes
Authors: Chinnagolla Ravi Kiran , Jeganmohan Masilamani 
Published: November 2011

AbstractThe reactions of substituted acetophenones with diphenylacetylene in the presence of [{RuCl2(p‐cymene)}2] (2 mol‐%), AgSbF6 (8 mol‐%), and Cu(OAc)2·H2O (25 mol‐%) in 1,2‐dichloroethane at 120 °C for 10 h provided substituted indenol derivatives in good‐to‐excellent yields. Under similar reaction conditions, unsymmetrical alkynes such as 1‐phenyl‐1‐propyne, 1‐phenyl‐1‐butyne, 1‐phenyl‐2‐(trimethylsilyl)acetylene, and a substituted enyne also reacted efficiently with substituted acetophenones to afford the corresponding indenol derivatives in a highly regioselective manner. The amount of silver salt plays a key role in the reaction. When the amount of silver salt exceeded more than 8 mol‐% in the presence of 2 mol‐% [{RuCl2(p‐cymene)}2], a different type of dehydration product, namely a benzofulvene derivative, started to appear. In the presence of 20 mol‐% AgSbF6, substituted acetophenones readily reacted with alkynes in the presence of [{RuCl2(p‐cymene)}2] (2 mol‐%) to give benzofulvene derivatives in excellent yields. A plausible reaction mechanism is proposed to account for the cyclization reaction.
Convergent Preparation of DimLex Hexasaccharide Analogues (Eur. J. Org. Chem. 34/2011)
Authors: Hendel Jenifer L. , Auzanneau France‐Isabelle 
Published: November 2011

AbstractThe cover picture shows an artist's impression of colorectal cancer cells displaying the tumor‐associated carbohydrate antigen dimeric Lex (dimLex). This hexasaccharide can be targeted for the development of anticancer vaccines that will help the immune system to selectively distinguish cancerous cells (Foe) from noncancerous cells (Friend). An analogue of the dimLex hexasaccharide in which a galactosyl residue was replaced by a glucose unit was prepared. This analogue will be used in the preparation of such a vaccine candidate. This cover picture was designed and produced by Dr. Uwe Oehler, Department of Chemistry, University of Guelph, Ontario, Canada. Details of this work are described in the article by J. L. Hendel and F.‐I. Auzanneau on p. 6864 ff.
Rapid determination of protein binding constant by a pressure‐mediated affinity capillary electrophoresis method
Authors: Zhang Bo , Li You X. , Gao He N. , Bian Juan , Bao James J. 
Published: November 2011

AbstractA new pressure‐mediated affinity capillary electrophoresis method for the rapid and accurate determination of drug–protein binding constants is described. A special combination of pressure and electrophoresis is used to shorten the electrophoresis and the overall analysis time to only a few minutes. At the same time, the suitability of this method is checked against a traditional fluorescence spectroscopy method. The binding constants of bovine serum albumin and a total of eight drugs with different pKa have been evaluated and compared with those determined by the fluorescence spectroscopy method and other methods in literature. The results indicate that the P‐ACE method is well suited for the determination of binding constants with weak interaction (Kb<105 M−1).
Modeling and Forecasting the Yield Curve by an Extended Nelson‐Siegel Class of Models: A Quantile Autoregression Approach
Authors: de Rezende Rafael B. , Ferreira Mauro S. 
Published: November 2011

ABSTRACTThis paper compares the in‐sample fitting and the out‐of‐sample forecasting performances of four distinct Nelson–Siegel class models: Nelson–Siegel, Bliss, Svensson, and a five‐factor model we propose in order to enhance the fitting flexibility. The introduction of the fifth factor resulted in superior adjustment to the data. For the forecasting exercise the paper contrasts the performances of the term structure models in association with the following econometric methods: quantile autoregression evaluated at the median, VAR, AR, and a random walk. As a pattern, the quantile procedure delivered the best results for longer forecasting horizons. Copyright © 2011 John Wiley & Sons, Ltd.
Estimation and Forecasting of Locally Stationary Processes
Authors: Palma Wilfredo , Olea Ricardo , Ferreira Guillermo 
Published: November 2011

ABSTRACTThis paper develops a state space framework for the statistical analysis of a class of locally stationary processes. The proposed Kalman filter approach provides a numerically efficient methodology for estimating and predicting locally stationary models and allows for the handling of missing values. It provides both exact and approximate maximum likelihood estimates. Furthermore, as suggested by the Monte Carlo simulations reported in this work, the performance of the proposed methodology is very good, even for relatively small sample sizes. Copyright © 2011 John Wiley & Sons, Ltd.
Emerging roles of p53 in glial cell function in health and disease
Authors: Jebelli Joseph D. , Hooper Claudie , Garden Gwenn A. , Pocock Jennifer M. 
Published: November 2011

AbstractEmerging evidence suggests that p53, a tumor suppressor protein primarily involved in cancer biology, coordinates a wide range of novel functions in the CNS including the mediation of pathways underlying neurodegenerative disease pathogenesis. Moreover, an evolving concept in cell and molecular neuroscience is that glial cells are far more fundamental to disease progression than previously thought, which may occur via a noncell‐autonomous mechanism that is heavily dependent on p53 activities. As a crucial hub connecting many intracellular control pathways, including cell‐cycle control and apoptosis, p53 is ideally placed to coordinate the cellular response to a range of stresses. Although neurodegenerative diseases each display a distinct and diverse molecular pathology, apoptosis is a widespread hallmark feature and the multimodal capacity of the p53 system to orchestrate apoptosis and glial cell behavior highlights p53 as a potential unifying target for therapeutic intervention in neurodegeneration. © 2011 Wiley Periodicals, Inc.
Stab wound injury of the zebrafish telencephalon: A model for comparative analysis of reactive gliosis
Authors: Baumgart Emily Violette , Barbosa Joana S. , Bally‐cuif Laure , Götz Magdalena , Ninkovic Jovica 
Published: November 2011

AbstractReactive glia, including astroglia and oligodendrocyte progenitors (OPCs) are at the core of the reaction to injury in the mammalian brain with initially beneficial and later partially adverse functions such as scar formation. Given the different glial composition in the adult zebrafish brain with radial ependymoglia but no parenchymal astrocytes, we examined the glial response to an invasive stab wound injury model in the adult zebrafish telencephalon. Strikingly, already a few days after injury the wound was closed without any scar tissue. Similar to mammals, microglia cells reacted first and accumulated close to the injury site, while neither GFAP+ radial ependymoglia nor adult OPCs were recruited to the injury site. Moreover, OPCs failed to increase their proliferation after this injury, while the number of proliferating GFAP+ glia was increased until 7 days after injury. Importantly, neurogenesis was also increased after injury, generating additional neurons recruited to the parenchyma which survived for several months. Thus, these data suggest that the specific glial environment in the adult zebrafish telencephalon is not only permissive for long‐term neuronal survival, but avoids scar formation. Invasive injury in the adult zebrafish telencephalon may therefore provide a useful model to untangle the molecular mechanisms involved in these beneficial glial reactions. © 2011 Wiley Periodicals, Inc.
No association between bone mass and prolactin levels among patients with schizophrenia
Authors: Sugawara Norio , Yasui‐Furukori Norio , Fujii Akira , Saito Manabu , Sato Yasushi , Nakagami Taku , Tsuchimine Shoko , Kaneko Sunao 
Published: November 2011

ObjectiveDecreased bone mineral density has been implicated in schizophrenic patients for long years. The purpose of this study was to assess the relationship between bone mass and prolactin levels in schizophrenic patients.MethodsIn this study, bone mass was measured using quantitative ultrasound densitometry of the calcaneus in 114 patients (49 males and 65 females). The osteosono‐assessment index (OSI) was calculated as a function of the speed of sound and transmission index. Estradiol, testosterone, and prolactin levels were also measured. Factors that influenced prolactin levels and bone mass were determined via multiple linear regression analysis.ResultsAmong the female patients, body mass index and estradiol levels were independently and significantly associated with the OSI. Neither prolactin levels nor duration of antipsychotic treatment was associated with bone mass for either gender.ConclusionsThese findings suggest that prolactin levels do not contribute to poor bone mass, as assessed using the OSI among schizophrenic patients. However, the interpretation of our results was hampered by lack of data including differences in lifestyle and type of antipsychotic medications used in schizophrenic patients. Association between prolactin levels and low bone mineral density was not completely ruled out. Future research exploring prolactin levels and bone mineral density is warranted. Copyright © 2011 John Wiley & Sons, Ltd.