bluuebunny/crossref_metadata_2025_split huggingface dataset:
Miracle friends and miracle money in California: a mixed-methods experiment of social support and guaranteed income for people experiencing homelessness
Authors: Henwood Benjamin F. , Kim Bo-Kyung Elizabeth , Stein Amy , Corletto Gisele , Suthar Himal , Adler Kevin F. , Mazzocchi Madeline , Ip Julia , Padgett Deborah K. 
Published: April 2024

Abstract
Background
This paper describes the protocols for a randomized controlled trial using a parallel-group trial design that includes an intervention designed to address social isolation and loneliness among people experiencing homelessness known as Miracle Friends and an intervention that combines Miracles Friends with an economic poverty-reduction intervention known as Miracle Money. Miracle Friends pairs an unhoused person with a volunteer “phone buddy.” Miracle Money provides guaranteed basic income of $750 per month for 1 year to Miracle Friends participants. The study will examine whether either intervention reduces social isolation or homelessness compared to a waitlist control group.

Methods
Unhoused individuals who expressed interest in the Miracle Friends program were randomized to either receive the intervention or be placed on a waitlist for Miracle Friends. Among those randomized to receive the Miracle Friends intervention, randomization also determined whether they would be offered Miracle Money. The possibility of receiving basic income was only disclosed to study participants if they were randomly selected and participated in the Miracle Friends program. All study participants, regardless of assignment, were surveyed every 3 months for 15 months.

Results
Of 760 unhoused individuals enrolled in the study, 256 were randomized to receive Miracle Friends, 267 were randomized to receive Miracle Money, and 237 were randomized to the waitlist control group. In the two intervention groups, 360 of 523 unhoused individuals were initially matched to a phone buddy. Of the 191 study participants in the Miracle Money group who had been initially matched to a volunteer phone buddy, 103 were deemed to be participating in the program and began receiving monthly income.

Discussion
This randomized controlled trial will determine whether innovative interventions involving volunteer phone support and basic income reduce social isolation and improve housing outcomes for people experiencing homelessness. Although we enrolled unhoused individuals who initially expressed interest in the Miracle Friends program, the study team could not reach approximately 30% of individuals referred to the study. This may reflect the general lack of stability in the lives of people who are unhoused or limitations in the appeal of such a program to some portion of the unhoused population.

Trial registration
ClinicalTrials.gov NCT05408884 (first submitted on May 26, 2022).
Efficacy of monthly treatment with oral fluralaner (Bravecto® 1-Month) against Tunga penetrans in dogs in Brazil: a randomized, double-blind, controlled field study
Authors: dos Santos Katharine Costa , Guedes Paula Elisa Brandão , Albuquerque George Rêgo , de Jesus Anderson Vieira , da Paixão Sevá Anaiá , de Oliveira Joana Thaisa Santos , de Carvalho Teixeira Jamille Bispo , Bitar Thammy Vieira , Harvey Tatiani Vitor , Ramos Sofia Nadir Sanches , Barufi Francisco Bonomi , de Almeida Borges Fernando , Carlos Renata Santiago Alberto 
Published: April 2024

Abstract
Background
Tungiasis is a neglected tropical disease caused by the adult female sand flea (Tunga penetrans). Dogs are considered important reservoirs of T. penetrans in Brazil. The aim of this study was to determine the monthly insecticidal efficacy of a single oral administration of fluralaner at a dose of 10–18 mg/kg (Bravecto® 1-Month, also registered as Defenza® in some countries; MSD Animal Health) in dogs naturally infested with T. penetrans.

Methods
This clinical trial was conducted in a rural community located in Ilhéus, Bahia, Brazil. A total of 64 dogs were selected and distributed in a completely randomized design between a treated group (TG) that received one single dose of Bravecto® 1-Month (Defenza®) and a negative control group (CG) that received no treatment. Each group was composed of 32 dogs. The evaluations took place on days 0, 7 ± 2, 14 ± 2, 21 ± 2, 28 ± 2, 35 ± 2, and 42 ± 2 post treatment, in which the dogs were inspected to evaluate the infestation stage and classify lesions associated with tungiasis. The primary efficacy was determined from the percentage of treated dogs free of fleas (stage II and III lesions) after administration of the formulation at each evaluation time. Secondary efficacy was based on the number of active lesions (stages II and III) in each group at each evaluation time. The clinical condition of the animals was defined based on the Severity Score for Acute Dog Tungiasis (SCADT), which is related to the number and severity of lesions.

Results
The primary efficacy of the product was greater than 95.0% from days 7 to 21 and reached 100.0% between days 28 and 42, with a significant association between treatment and infestation decline (P < 0.025) between days 7 and 42. Secondary drug efficacy was greater than 99.9% from days 7 to 21, reaching 100.0% between days 28 and 42 (P < 0.05). The treated dogs also scored lower on the SCADT than the control animals did during the entire clinical evaluation period (P < 0.05).

Conclusions
A single administration of Bravecto® 1-Month (Defenza®) was effective in eliminating Tunga penetrans infestations, as well as in preventing parasitism for at least 42 days after treatment.

Graphical Abstract
Prediction of half-marathon performance of male recreational marathon runners using nomogram
Authors: Shu Dingbo , Wang Jianping , Zhou Tong , Chen Feng , Meng Fanjing , Wu Xiaoyin , Zhao Zhenhua , Dai Siyu 
Published: April 2024

Abstract
Background
Long-distance running is a popular competitive sport. We performed the current research as to develop an easily accessible and applicable model to predict half-marathon performance in male recreational half-marathon runners by nomogram.

Methods
Male recreational half-marathon runners in Zhejiang Province, China were recruited. A set of literature-based and panel-reviewed questionnaires were used to assess the epidemiological conditions of the recruited runners. Descriptive and binary regression analyses were done for the profiling and identification of predictors related to higher half-marathon performance (completing time ≤ 105 min). Participants were assigned to the training set (n = 141) and the testing set (n = 61) randomly. A nomogram was used to visually predict the half-marathon performance, and the receiver operating characteristic (ROC) was used to evaluate the predictive ability of the nomogram.

Results
A total of 202 participants (median age: 49 years; higher half-marathon performance: 33.7%) were included. After multivariate analysis, three variables remained as significant predictors: longer monthly running distance [adjusted odds ratio (AOR) = 0.992, 95% confidence interval (CI): 0.988 to 0.996, p < 0.001], faster mean training pace (AOR = 2.151, 95% CI: 1.275 to 3.630, p < 0.001), and better sleep quality [the Pittsburgh Sleep Quality Index (PSQI), AOR = 2.390, 95% CI: 1.164 to 4.907, p = 0.018]. The AUC of the training and testing sets in nomogram were 0.750 and 0.743, respectively. Further ternary and linear regression analyses corroborated the primary findings.

Conclusions
This study developed a nomogram with good potential to predict the half-marathon performance of recreational runners. Our results suggest that longer monthly running distance, faster mean training pace and better sleep quality notably contribute to better half-marathon performance.
Inclusion of the severe and enduring anorexia nervosa phenotype in genetics research: a scoping review
Authors: Ramsay Sarah , Allison Kendra , Temples Heide S. , Boccuto Luigi , Sarasua Sara M. 
Published: April 2024

Abstract
Background
Anorexia nervosa has one of the highest mortality rates of all mental illnesses. For those who survive, less than 70% fully recover, with many going on to develop a more severe and enduring phenotype. Research now suggests that genetics plays a role in the development and persistence of anorexia nervosa. Inclusion of participants with more severe and enduring illness in genetics studies of anorexia nervosa is critical.

Objective
The primary goal of this review was to assess the inclusion of participants meeting the criteria for the severe enduring anorexia nervosa phenotype in genetics research by (1) identifying the most widely used defining criteria for severe enduring anorexia nervosa and (2) performing a review of the genetics literature to assess the inclusion of participants meeting the identified criteria.

Methods
Searches of the genetics literature from 2012 to 2023 were performed in the PubMed, PsycINFO, and Web of Science databases. Publications were selected per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). The criteria used to define the severe and enduring anorexia nervosa phenotype were derived by how often they were used in the literature since 2017. The publications identified through the literature search were then assessed for inclusion of participants meeting these criteria.

Results
most prevalent criteria used to define severe enduring anorexia nervosa in the literature were an illness duration of ≥ 7 years, lack of positive response to at least two previous evidence-based treatments, a body mass index meeting the Diagnostic and Statistical Manual of Mental Disorders-5 for extreme anorexia nervosa, and an assessment of psychological and/or behavioral severity indicating a significant impact on quality of life. There was a lack of consistent identification and inclusion of those meeting the criteria for severe enduring anorexia nervosa in the genetics literature.

Discussion
This lack of consistent identification and inclusion of patients with severe enduring anorexia nervosa in genetics research has the potential to hamper the isolation of risk loci and the development of new, more effective treatment options for patients with anorexia nervosa.
Psychosocial resources and psychopathology among persons with neuromuscular disorders during the COVID-19 pandemic
Authors: Sanzo’ Silvia , Tizzoni Federica , Previtali Stefano C. , Berardinelli Angela , Nobile Maria , Molteni Massimo , Manzoni Martina , Tarabelloni Arianna , Russo Annamaria , Delle Fave Antonella , D’Angelo Maria Grazia 
Published: April 2024

Abstract
Background
The COVID-19 pandemic substantially affected the lives of persons with inherited neuromuscular disorders (INMD), causing disruption in clinical and support services. While several studies have investigated mental health, distress and psychosocial resources in the general population during the pandemic, little is known about the experience of persons with INMD.

Methods
This study was aimed to fill this gap by jointly investigating both psychopathological symptoms and psychosocial resources – specifically, resilience and perceived social support – among persons with INMD during the pandemic, taking into account demographic and clinical factors. Between April and December 2020, 59 participants with INMD (aged 15–59, 71.2% M) completed a questionnaire collecting demographic and clinical data, the Multidimensional Scale of Perceived Social Support, the Resilience Scale for Adults, and the Achenbach System of Empirically Based Assessment.

Results
Overall, participants showed good levels of resilience and perceived social support. A minority of participants reported clinically relevant psychopathological symptoms, 28.81% for anxiety and depression. Most psychopathological symptoms were negatively correlated with resilience (-0.347 < r < − .420), but not significantly associated with social support. Consistent with previous studies, regression analyses highlighted that participants with Duchenne muscular dystrophy were more prone to report anxious and depressive symptoms (B = 1.748, p = .028, OR = 5.744), and participants with myotonic dystrophy, attention problems (B = 2.339, p = .006, OR = 10.376). Resilience emerged as a potential predictor of lower anxious-depressive symptoms (B=-1.264, p = .012, OR = 0.283).

Conclusions
The findings suggest the importance to investigate psychosocial resources in addition to psychopathology among persons with INMD, and to design interventions supporting resilience as a protective factor for mental health promotion.
Plasma ALS and Gal-3BP differentiate early from advanced liver fibrosis in MASLD patients
Authors: Pérez Compte David , Etourneau Lucas , Hesse Anne-Marie , Kraut Alexandra , Barthelon Justine , Sturm Nathalie , Borges Hélène , Biennier Salomé , Courçon Marie , de Saint Loup Marc , Mignot Victoria , Costentin Charlotte , Burger Thomas , Couté Yohann , Bruley Christophe , Decaens Thomas , Jaquinod Michel , Boursier Jérôme , Brun Virginie 
Published: April 2024

Abstract
Background
Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect 30% of the world’s population, and its prevalence is increasing in line with obesity. Liver fibrosis is closely related to mortality, making it the most important clinical parameter for MASLD. It is currently assessed by liver biopsy – an invasive procedure that has some limitations. There is thus an urgent need for a reliable non-invasive means to diagnose earlier MASLD stages.

Methods
A discovery study was performed on 158 plasma samples from histologically-characterised MASLD patients using mass spectrometry (MS)-based quantitative proteomics. Differentially abundant proteins were selected for verification by ELISA in the same cohort. They were subsequently validated in an independent MASLD cohort (n = 200).

Results
From the 72 proteins differentially abundant between patients with early (F0-2) and advanced fibrosis (F3-4), we selected Insulin-like growth factor-binding protein complex acid labile subunit (ALS) and Galectin-3-binding protein (Gal-3BP) for further study. In our validation cohort, AUROCs with 95% CIs of 0.744 [0.673 – 0.816] and 0.735 [0.661 – 0.81] were obtained for ALS and Gal-3BP, respectively. Combining ALS and Gal-3BP improved the assessment of advanced liver fibrosis, giving an AUROC of 0.796 [0.731. 0.862]. The {ALS; Gal-3BP} model surpassed classic fibrosis panels in predicting advanced liver fibrosis.

Conclusions
Further investigations with complementary cohorts will be needed to confirm the usefulness of ALS and Gal-3BP individually and in combination with other biomarkers for diagnosis of liver fibrosis. With the availability of ELISA assays, these findings could be rapidly clinically translated, providing direct benefits for patients.

Graphical Abstract
Classification of geologic materials used in the Sukhothai Historical Park of Thailand using a portable X-ray fluorescence analyzer and petrographic analysis
Authors: Singtuen Vimoltip , Jansamut Supaporn , Pongsaisri Nucharee , Phajuy Burapha 
Published: April 2024

Abstract
The Sukhothai Historical Park, designated as a world heritage site in Thailand, encompasses the remnants of the Sukhothai Kingdom and serves as a valuable locus for geological and geoarchaeological investigations. Situated in the Sukhothai province, the region is characterized by diverse lithologies, including slate, phyllite, and laterite, as well as red bricks (synthetic materials), utilized in the construction of various ancient structures. Petrographic analysis using polarized light microscopy reveals the phyllites as the primary dimension stones, exhibiting foliated and mylonitic textures with small quartz augen. A portable X-ray fluorescence analyzer was employed for geochemical analysis and the analysis of major oxides and trace elements. The resulting data facilitated the classification of protoliths and comparison with rocks from an abandoned quarry near Saritphong Dam in the western part of the historical park. Notably, phyllites utilized in several prominent structures within the park; Wat Saphan Hin, Wat Pa Daeng 2, Wat Thap Sakae, Wat Chetuphon, Wat Sri Chum, and Wat Mangkorn Temples, exhibited similar characteristics to those in the Wat Khao Noi old quarry, as confirmed by Rubidium (Rb) and Strontium (Sr) values. The SiO2/Al2O3 and FeO/K2O ratios were pivotal in identifying the protoliths of the studied phyllites as shales. In summary, the primary dimension stones for Sukhothai Historical Park originated from the western mountain within the park, with laterites sourced from foothill areas. The presence of quartz pebbles in red bricks suggests local sediment utilization, and quartz additions were employed to enhance structural strength. This comprehensive geoarchaeological study sheds light on the geological composition of the Sukhothai Historical Park, providing valuable insights into the selection and utilization of construction materials in this historically significant site.
Ultra-Cycling– Past, Present, Future: A Narrative Review
Authors: Tiemeier Lucas , Nikolaidis Pantelis T. , Chlíbková Daniela , Wilhelm Matthias , Thuany Mabliny , Weiss Katja , Knechtle Beat 
Published: April 2024

AbstractBackgroundUltra-endurance events are gaining popularity in multiple exercise disciplines, including cycling. With increasing numbers of ultra-cycling events, aspects influencing participation and performance are of interest to the cycling community.Main bodyThe aim of this narrative review was, therefore, to assess the types of races offered, the characteristics of the cyclists, the fluid and energy balance during the race, the body mass changes after the race, and the parameters that may enhance performance based on existing literature. A literature search was conducted in PubMed, Scopus, and Google Scholar using the search terms ‘ultracycling’, ‘ultra cycling’, ‘ultra-cycling’, ‘ultra-endurance biking’, ‘ultra-bikers’ and ‘prolonged cycling’. The search yielded 948 results, of which 111 were relevant for this review. The studies were classified according to their research focus and the results were summarized. The results demonstrated changes in physiological parameters, immunological and oxidative processes, as well as in fluid and energy balance. While the individual race with the most published studies was the Race Across America, most races were conducted in Europe, and a trend for an increase in European participants in international races was observed. Performance seems to be affected by characteristics such as age and sex but not by anthropometric parameters such as skin fold thickness. The optimum age for the top performance was around 40 years. Most participants in ultra-cycling events were male, but the number of female athletes has been increasing over the past years. Female athletes are understudied due to their later entry and less prominent participation in ultra-cycling races. A post-race energy deficit after ultra-cycling events was observed.ConclusionFuture studies need to investigate the causes for the observed optimum race age around 40 years of age as well as the optimum nutritional supply to close the observed energy gap under consideration of the individual race lengths and conditions. Another research gap to be filled by future studies is the development of strategies to tackle inflammatory processes during the race that may persist in the post-race period.
Reimagining and reinterpreting Cooper pairs, the Fermi sea, Pauli blocking and superfluidity: The Pauli principle in collective motion
Authors: Watson D. K. 
Published: April 2024

Abstract
Identifying possible microscopic mechanisms underlying superfluidity has been the goal of various studies since the introduction of the original BCS theory. Recently a series of papers have proposed microscopic dynamics based on normal modes to describe superfluidity without the use of real-space Cooper pairs. Multiple properties were determined with excellent agreement with experimental data. The group theoretic basis of this general N-body approach has allowed the microscopic behavior underlying these results to be analyzed in detail. This reimagination is now used to reinterpret several interrelated phenomena including Cooper pairs, the Fermi sea, and Pauli blocking. This approach adheres closely to the early tenets of superconductivity/superfluidity which assumed pairing only in momentum space, not in real space. The Pauli principle is used, in its recently revealed role in collective motion, to select the allowed normal modes. The expected properties of superfluidity including the rigidity of the wave function, interactions between the fermions in different pairs, convergence of the momentum and the gap in the excitation spectrum are discussed.
Structural and phonon anomalies in the superconducting
with varying doping level at high pressures
Authors: Xin Jie , Zhang Jian-Bo , Gu Gen-Da , Gavriliuk Alexander G. , Lyubutin Igor , Struzhkin Viktor V. , Chen Xiao-Jia 
Published: April 2024

Abstract
We examined the effect of the lattice compression on the crystal structure of the Bi2Sr2CaCu2

superconductor with nearly optimally doped and overdoped composition using X-ray diffraction technique. Our studies show that at high pressures (up to 30 GPa ) the doping level does not affect the crystal structure of this superconductor. Along with this, structural anomalies in

ratio appear at a pressure that corresponds to that at which T

c
begins to decrease. This fact indicates a close connection between the observed anomalies and superconductivity. We also studied the effect of doping and pressure on the T

c
(P) and on the Raman active lattice modes of the Bi2Sr2CaCu2

superconductors. We find universal suppression of the T

c
by the pressure starting from the critical pressure P

c
in the range from 9 to 16 GPa, depending on the doping level of the Bi2Sr2CaCu2

samples. Concomitantly, we observe phonon anomalies around 10 to 20 GPa, which indicate possible pressure-induced charge redistribution in BiO layers. These newly detected anomalies may be related to the changes in the electronic structure which compete with the superconductivity.
Glycoprotein-glycoprotein Receptor Binding Detection Using Bioluminescence Resonance Energy Transfer
Authors: Adamczuk Kamila , Ngo Thu Ha , Czapiński Jakub , Rivero-Müller Adolfo 
Published: April 2024

Abstract
The glycoprotein receptors, members of the large G protein-coupled receptor family, are characterized by a large extracellular domains responsible for binding their glycoprotein hormones. Hormone-receptor interactions are traditionally analyzed by ligand-binding assays, most often using radiolabeling but also by thermal shift assays. Despite their high sensitivity, these assays require appropriate laboratory conditions and, often, purified plasma cell membranes, which do not provide information on receptor localization or activity because the assays typically focus on measuring binding only. Here, we apply bioluminescence resonance energy transfer in living cells to determine hormone-receptor interactions between a Gaussia luciferase (Gluc)-luteinizing hormone/chorionic gonadotropin receptor (LHCGR) fusion and its ligands (human chorionic gonadotropin or LH) fused to the enhanced green fluorescent protein. The Gluc-LHCGR, as well as other Gluc-G protein-coupled receptors such as the somatostatin and the C-X-C motif chemokine receptors, is expressed on the plasma membrane, where luminescence activity is equal to membrane receptor expression, and is fully functional. The chimeric enhanced green fluorescent protein-ligands are properly secreted from cells and able to bind and activate the wild-type LHCGR as well as the Gluc-LHCGR. Finally, bioluminescence resonance energy transfer was used to determine the interactions between clinically relevant mutations of the hormones and the LHCGR that show that this bioassay provides a fast and effective, safe, and cost-efficient tool to assist the molecular characterization of mutations in either the receptor or ligand and that it is compatible with downstream cellular assays to determine receptor activation/function.