bluuebunny/crossref_metadata_2025_split huggingface dataset:
TAF15 downregulation contributes to the benefits of physical training on dendritic spines and working memory in aged mice
Authors: He Yun , Liu Benju , Yang Fu‐Yuan , Yang Qun , Xu Benke , Liu Lian , Chen Yuncai 
Published: June 2024

AbstractModerate physical training has been shown to hinder age‐related memory decline. While the benefits of physical training on hippocampal memory function are well‐documented, little is known about its impact on working memory, which is linked to the prelimbic cortex (PrL), one major subdivision of the prefrontal cortex. Here, we examined the effects of physical training on spatial working memory in a well‐established animal model of physical training, starting at 16 months of age and continuing for 5 months (running wheel 1 h/day and 5 days/week). This training strategy improved spatial working memory in aged mice (22‐month‐old), which was accompanied by an increased spine density and a lower TAF15 expression in the PrL. Specifically, physical training affected both thin and mushroom‐type spines on PrL pyramidal cells, and prevented age‐related loss of spines on selective segments of apical dendritic branches. Correlation analysis revealed that increased TAF15‐expression was detrimental to the dendritic spines. However, physical training downregulated TAF15 expression in the PrL, preserving the dendritic spines on PrL pyramidal cells and improving working memory in trained aged mice. When TAF15 was overexpressed in the PrL via a viral approach, the benefits of physical training on the dendritic spines and working memory were abolished. These data suggest that physical training at a moderate pace might downregulate TAF15 expression in the PrL, which favors the dendritic spines on PrL pyramidal cells, thereby improving spatial working memory.
Geriatric screening in the emergency department increases consultations to geriatric medicine and physical and occupational therapy: A pre/post cohort study
Authors: Hunold Katherine M. , Caterino Jeffrey M. , Carpenter Christopher R. , Mion Lorraine C. , Southerland Lauren T. 
Published: June 2024

AbstractBackgroundThe Geriatric Emergency Department (ED) Guidelines recommend screening older patients for need for evaluation by geriatric medicine, physical therapy (PT), and occupational therapy (OT), but explicit evidence that geriatric screening changes care compared to physician gestalt is lacking. We assessed changes in multidisciplinary consultation after implementation of standardized geriatric screening in the ED.MethodsRetrospective single‐site observational cohort of older adult ED patients from 2019 to 2023 with three time periods: (1) preimplementation, (2) implementation of geriatric screening, and (3) postimplementation. Geriatric, PT, and OT consultations/referrals were available during all time periods. Descriptive analysis was stratified by disposition: discharged, observation and discharged, observation and hospital admission, and hospital admission. The independent variable was completion of three geriatric screening tools by ED nurses. The dependent variable was consultation and/or referral to geriatrics, PT, and OT. Secondary outcomes were disposition, ED revisits, and 30‐day rehospitalizations.ResultsThere were 57,775 qualifying ED visits of patients age ≥ 65 years during the time periods: implementation increased geriatric screening from 0.5% to 63.2%; postimplementation, discharge patients who received screening had more consultations/referrals to geriatrics (1.5% vs. 0.4%), PT (7.9% vs. 1.9%), and OT (6.5% vs. 1.2%) compared to unscreened patients. Patients observed and then discharged had more consultations/referrals to geriatrics (15.1% vs. 11.3%), PT (74.1% vs. 64.5%), and OT (65.7% vs. 56.5%). Admitted patients had no change in consultation rates. Geriatric screening was not associated with a change in 7‐day ED revisits for discharged patients but was associated with decreased revisits for patients discharged from observation (11.6% vs. 42.9%, p < 0.001).ConclusionGeriatric screening was associated with increased consultations/referrals to geriatrics, PT, and OT in the ED and ED observation unit. This suggests that geriatric screening changes ED care for older adults.
Morbidity following robot‐assisted surgery in a gynecological oncology setting: A cohort study
Authors: Markauskas Algirdas , Blaakær Jan , Traen Koen Josef , Neumann Gudrun Astrid , Chunsen Wu , Petersen Lone Kjeld 
Published: June 2024

AbstractIntroductionThe objective of the study was to provide a comprehensive description of perioperative morbidity associated with robot‐assisted surgery (RAS) in a gynecological oncology setting in order to improve the preoperative counseling of women and support shared decision‐making.Material and MethodsAll women scheduled for intended RAS between January 2015 and December 2022 were prospectively included in an electronic morbidity database for the analyses of perioperative complications.ResultsIn total, 2225 women were included. Sixty‐four patients (2.9%) experienced an intraoperative complication. Intraoperative complications were associated with a higher rate of conversion to laparotomy (15.6% vs. 1.8%, p < 0.001), a higher rate of major postoperative morbidity (9.3% vs. 2.4%, p < 0.001), and a higher rate of reoperation (9.3% vs. 1.7%, p < 0.001), compared to cases without intraoperative complications. Thirty‐day postoperative morbidity was evaluated according to the Memorial Sloan‐Kettering Cancer Center Surgical Secondary Events Grading System. Grade 3–5 events were considered major. A total of 57 patients (2.6%) experienced a major event after surgery, postoperative rupture of the vaginal vault being the most common complication requiring surgical intervention. Conversion to laparotomy occurred in 49 cases (2.2%) and was associated with higher intraoperative blood loss (300 mL vs. 25 mL, p < 0.001), a higher rate of postoperative major events (20.4% vs. 2.2%, p < 0.001), and a higher rate of reoperation (11.8% vs. 1.6%, p < 0.001).ConclusionsOur study demonstrates low rates of major perioperative morbidity and conversion to laparotomy after RAS performed by trained high‐volume surgeons in a gynecological oncology setting.
Placental architectural characteristics following laser ablation within monochorionic twins complicated by twin–twin transfusion syndrome: A systematic review and meta‐analysis of outcomes
Authors: Hamer Jack , Eltaweel Nashwa , Man Rebecca , Rogerson Matilde , Hodgetts Morton Victoria , Morris R. Katie , Marton Tamas , Gurney Leo 
Published: June 2024

AbstractIntroductionTwin–twin transfusion syndrome (TTTS) complicates approximately 10%–15% of all monochorionic twin pregnancies. The aim of this review was to evaluate the placental architectural characteristics within TTTS twins following laser and elucidate their impact on fetal outcomes and operative success.Material and MethodsFive databases were searched from inception to August 2023. Studies detailing post‐delivery placental analysis within TTTS twins post‐laser were included. Studies were categorized into two main groups: (1) residual anastomoses following laser and (2) abnormal cord insertion: either velamentous and/or marginal or proximate. The primary outcome was to determine the proportion of TTTS placentas with residual anastomoses and abnormal cord insertions post‐laser. Secondary outcomes included assessing residual anastomoses on post‐laser fetal outcomes and assessing the relationship between abnormal cord insertion and TTTS development. Study bias was critiqued using the Joanna Briggs Institute checklists and Cochrane risk of bias tool. Random‐effects meta‐analysis was used, and results were reported as pooled proportions or odds ratio (OR) with 95% confidence interval (CI). PROSPERO registration: CRD42023476875.ResultsTwenty‐six studies, comprising 4013 monochorionic twins, were included for analysis. The proportion of TTTS placentas with residual anastomoses following laser was 24% (95% CI, 0.12–0.41), with a mean and standard deviation of 4.03 ± 2.95 anastomoses per placenta. Post‐laser residual anastomoses were significantly associated with intrauterine fetal death (OR, 2.38 [95% CI, 1.33–4.26]), neonatal death (OR, 3.37 [95% CI, 1.65–6.88]), recurrent TTTS (OR, 24.33 [95% CI, 6.64–89.12]), and twin anemia polycythemia sequence (OR, 13.54 [95% CI, 6.36–28.85]). Combined abnormal cord (velamentous and marginal), velamentous cord, and marginal cord insertions within one or both twins following laser were reported at rates of 49% (95% CI, 0.39–0.59), 27% (95% CI, 0.18–0.38), and 28% (95% CI, 0.21–0.36), respectively. Combined, velamentous and marginal cord insertions were not significantly associated with TTTS twins requiring laser (p = 0.72, p = 0.38, and p = 0.71, respectively) vs non‐TTTS monochorionic twins.ConclusionsTo the best of our knowledge, this is the first review to conjointly explore outcomes of residual anastomoses and abnormal cord insertions within TTTS twins following laser. A large prospective study is necessitated to assess the relationship between abnormal cord insertion and residual anastomoses development post‐laser.
Expiratory and inspiratory resistance and reactance from respiratory oscillometry defining expiratory flow limitation in obstructive lung diseases
Authors: Nasr Abir , Papapostolou Georgia , Jarenbäck Linnea , Romberg Kerstin , Tunsäter Alf , Ankerst Jaro , Bjermer Leif , Tufvesson Ellen 
Published: June 2024

AbstractBackgroundExpiratory flow limitation (EFL) during tidal breathing and lung hyperinflation have been identified as major decisive factors for disease status, prognosis and response to therapy in obstructive lung diseases.AimTo investigate the delta values between expiratory and inspiratory resistance and reactance, measured using respiratory oscillometry and its correlation with air trapping and symptoms in subjects with obstructive lung diseases.MethodsFour hundred and seventy‐one subjects (96 with chronic obstructive pulmonary disease [COPD], 311 with asthma, 30 healthy smokers and 34 healthy subjects) were included. Spirometry, body plethysmography and respiratory oscillometry measurements were performed and the differences between the expiratory and inspiratory respiratory oscillometry values (as delta values) were calculated. Questionnaires regarding symptoms and quality of life were administered.ResultsPatients with COPD and healthy smokers had an increased delta resistance at 5 Hz (R5) compared with patients with asthma (p < 0.0001 and p = 0.037, respectively) and healthy subjects (p = 0.0004 and p = 0.012, respectively). Patients with COPD also had higher values of ΔR5–R19 than healthy subjects (p = 0.0001) and patients with asthma (p < 0.0001). Delta reactance at 5 Hz (X5) was significantly more impaired in COPD patients than in asthma and healthy subjects (p < 0.0001 for all). There was a correlation between the ratio of residual volume and total lung capacity and ΔR5 (p = 0.0047; r = 0.32), ΔR5–R19 (p = 0.0002; r = 0.41) and ΔX5 (p < 0.0001; r = −0.44), for all subjects. ΔX5 correlated with symptoms in COPD, healthy smokers and patients with asthma. In addition, ΔR5 correlated with asthma symptoms.ConclusionEFL was most prominent in parameters measuring peripheral resistance and reactance and correlated with air trapping and airway symptoms.
Effect of bowel preparation completion time on bowel cleansing efficacy: Prospective randomized controlled trial of different bowel preparation completion times precolonoscopy
Authors: Kim Hye Min , Kim Hyo Suk , An Young Eun , Chang Jae Hyuck , Kim Tae Ho , Kim Chang Whan , Gweon Tae‐Geun 
Published: June 2024

ObjectivesThe elapse time between the completion of bowel cleansing and colonoscopy is one of the important factors for proper bowel cleansing. Although several studies have reported that a short time interval resulted in a favorable bowel cleansing, no randomized controlled trial (RCT) has been conducted to determine the effect of the elapse time. Consequently, we performed an RCT to investigate the efficacy of bowel preparation of participants who underwent colonoscopy according to the different time intervals between the completion of bowel preparation and colonoscopy.MethodsIn this single‐center RCT, study participants were randomized to complete bowel preparation either 2–4 h or 4–8 h before colonoscopy. The primary end‐point was successful bowel preparation, rated using the Boston Bowel Preparation Scale (BBPS).ResultsA total of 504 individuals were included (2–4 h, 255; 4–8 h, 249). The rate of successful bowel preparation in the 2–4 h group showed noninferiority compared with that of the 4–8 h group (97.6% vs. 95.2%; rate difference, 2.5% [−0.8% to 5.7%]; Pfor noninferiority < 0.001, Pfor superiority = 0.136). The rate for perfect cleansing (a BBPS score of 9) was higher in the 2–4 h group (56.5% vs. 39.8%, P < 0.001).ConclusionWhen bowel cleansing was finished 2–4 h before the start of colonoscopy, the overall bowel cleansing was noninferior, and perfect cleansing was superior, compared to that when cleansing was finished 4–8 h before colonoscopy.
Spawning periodicity and possible public information use for Nest site selection in the bluehead chub (Nocomis leptocephalus)
Authors: Bustamante Thomas , Frimpong Emmanuel 
Published: June 2024

AbstractNesting animals require information about their environment to place nests in optimal locations. This information can either be derived from an animal's previous experiences (private information), or it may be gained through the observation of the success of conspecifics (public information). This use of public information to locate suitable nesting sites has been explored in birds but not fishes. Many fish construct nests to protect their offspring, and the utilisation of public information could be a suitable strategy for determining which nesting locations would maximise fitness. We studied public and private information use in the bluehead chub, a species of nesting leuciscid in the Southeastern United States, by observing nesting activity and measuring habitat variables along a 0.65 km reach of Toms Creek in Blacksburg, Virginia. We clustered activity data and created generalised linear models to determine if bluehead chubs construct nests within discrete nesting periods during the spawning season and if they use public or private information to select nest sites between these periods. Our results suggest that bluehead chubs construct nests periodically within a single spawning season and use a combination of public and private information when determining suitable nesting sites from one nesting period to another. This study provides some of the first evidence suggesting public information use for nest site selection in a species of fish and opens up a new frontier of research into public information use among fishes.
Taxonomic and functional homogenization of fish assemblages in an Ozark river associated with pasture land use and constructed water bodies
Authors: Morrill Daniel P. , Main Jennifer , Davenport Grace , Adams Ginny L. , Adams Steven Reid 
Published: June 2024

AbstractComparisons between contemporary and historic surveys are useful in assessing how fish assemblages respond to anthropogenic stressors. When these stressors degrade aquatic environments, assemblages often experience biotic homogenization. The Strawberry River flows through the Ozarks of northern Arkansas and has been subject to both pasture land use conversion and constructed waterbodies which can degrade aquatic environments and alter fish assemblages. We investigated how fish assemblages in the Strawberry River have changed over a 35‐year time span in response to pasture land use and constructed waterbodies. We found evidence of both taxonomic and functional homogenization of fish assemblages from the mid‐1980s to 2019. This shift towards homogenization was primarily driven by increases in both site occurrence and abundance of generalist centrarchid species (associated with land use practices) and headwater specialist species (likely related to increased intermittency upstream). We created a composite variable using principal component analysis that represented pasture land use and constructed water body metrics because of their close relationship with each other. We found evidence of early functional differentiation associated with this composite variable; however, we found that over time fish assemblages ultimately experienced greater levels of homogenization associated with this same variable. This pattern of biotic homogenization associated with species additions suggests the Strawberry River is at a tipping point along a subsidy stress gradient, and in the future, we expect to see losses of specialist endemic species if conservation actions are not taken.
A return of economic intervention in advanced democracies after the financial and economic crisis (2008/2009)?
Authors: Zohlnhöfer Reimut , Jathe Jan , Engler Fabian 
Published: June 2024

AbstractDid the financial and economic crisis (2008/2009) induce a permanent shift to more economic intervention in the advanced democracies? Three relevant theoretical perspectives are considered. First, the crisis could have led all governments to intervene more, irrespective of their partisan composition. Second, voter demand could have shifted towards more intervention due to the crisis, again inducing all governments to expand economic intervention. Third, increasing salience of economic issues could have led to an accentuation of partisan differences in economic policy which should have led to an expansion of economic intervention under left governments only. We present data from a new index of economic intervention, which show that governments increased economic intervention during the immediate crisis but returned to liberalization afterward. Similarly, statistical analyses show that partisan differences disappear during the acute crisis but return thereafter. Hence, the financial and economic crisis did not constitute a game‐changer in economic policymaking in advanced democracies.
NARRATIVITY, EXPERIENCE, AND MEANING1
Authors: Stanciu Ovidiu 
Published: June 2024

ABSTRACTThis review essay aims to reconstruct the main tenets of the “narrative constructivist” position defended by Kalle Pihlainen in his book titled Historia fallida and to lay out some of the ambiguities this position generates. I begin by exposing the core commitments underwriting this theoretical project and insist upon the centrality of the distinction between constructivism and constructionism and upon the arguments he advances against the contemporary approaches in the theory of history that advocate the idea of an experience or a presence of the past. Then, I outline the criticism he levels against the understanding of historians’ work as a “conversation with the past” and highlight that, on Pihlainen's account, a responsible historical enterprise must necessarily assume the unavailability of the past and, hence, the ontological distinction between the present and the past. In the final part of the essay, I formulate three interrogations with regard to the overall orientation of this project. First, drawing on Reinhart Koselleck's concept of a “historical nonsynchronicity,” I question the possibility of establishing a clear‐cut separation between the past and the present and show that the present is never a homogenous field, for it entails different levels of temporality and a plurality of conflicting registers of meaning. Then, I challenge the description of the past as “a closed domain with no room for interaction.” Finally, I point out that the gap Pihlainen introduces between historical narratives and existential narratives cannot be maintained insofar as the historian's practice must be anthropologically grounded—that is, it must be understood as drawing on a narrative capacity (narrativeness) that belongs to the human life‐form.
Adult and infantile seborrheic dermatitis: update on current state of evidence and potential research frontiers
Authors: Rau Akash , Silva Genevieve S. , Margolis David J. , Chiesa Fuxench Zelma C. 
Published: June 2024

AbstractSeborrheic dermatitis (SD) is a highly prevalent dermatological condition globally. The condition demonstrates bimodal presentation with what is commonly thought to be two subtypes: adult/adolescent seborrheic dermatitis (ASD) and infantile seborrheic dermatitis (ISD). Despite the common prevalence of ASD and ISD, there remains uncertainty around the underlying pathogenetic mechanisms, risk factors, and appropriate classification of the disease(s). This narrative review summarizes the current understanding of the epidemiology, presentation, and pathogenetic factors like epidermal barrier dysfunction, lipid abnormalities, and cutaneous microbiome for ASD and ISD. Elements such as immune responsiveness, neuroendocrine factors, and genetics in these disease states are also investigated. Throughout our review, we highlight shared features and discrepancies between ASD and ISD that are present in the literature and discuss potential avenues for future research that explore these disease states. We aim to contribute to the medical discourse on ASD and ISD and increase awareness of the need for additional research around these conditions, ultimately informing better targeting of therapeutics moving forward.
Personality development goals at work: A new frontier in personality assessment in organizations
Authors: Dupré Sofie , Wille Bart 
Published: June 2024

AbstractThere is a long and successful history of personality research in organizational contexts and personality assessments are now widely used in a variety of human resources or talent management interventions. In this tradition, assessment typically involves describing (future) employees' personality profiles, and then using this information to select or adapt work roles to optimally meet employees' traits. Although useful, one limitation of this approach is that it overlooks employees' motivations and abilities to develop themselves in their pursuit of greater person‐environment fit. This paper therefore argues for a new type of personality assessment that goes beyond the current descriptive approach. Specifically, we propose assessing employees' Personality Development Goals (PDGs) at work to complement the traditional assessment of “who are you?” with information about “who do you want to be?”. We first briefly summarize the current approach to personality assessment and highlight its limitations. Then, we take stock of the research on PDGs in clinical and personality literatures, and outline the reasons for translating this into organizational applications. We end by describing the key principles that should inform the implementation of PDGs at work and propose a number of future research directions to support and advance this practice.
Nurturing a positive research culture within your organization
Authors: Liston Adrian , Fitzgerald Denise C 
Published: June 2024

AbstractPositive research cultures provide the environment for scientists to explore ideas, grow as individuals, develop team science and create a positive impact on those around them. While positive research cultures need to grow from the kindness and integrity of team members, organization policy can either help or hinder this organic positive behavior. A focus on policies to enhance positive research culture can benefit even high‐functioning organizations, by expanding and extending the benefits. Here we focus on key actionable areas to create and reinforce a positive research culture in your organization. We discuss the role of aligning staff recognition to the organization's missions, the influence of the organization unit and career structure on the research culture, the pyramid of building respectful interactions, the value of openness and transparency and the overarching goal of equality, diversity and inclusivity within the organization.