bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urticaria induced by laser epilation: A clinical and histopathological study with extended follow‐up in 36 patients
Authors: Landa Nerea , Corrons Natalia , Zabalza Iñaki , Azpiazu Jose L. 
Published: April 2012

AbstractBackgroundLaser epilation is the most common dermatologic light‐based procedure in the world. We describe a unique side effect of the procedure: a delayed persistent urticarial rash.Patients and methodsWe conducted a retrospective study involving 13,284 patients who received laser epilation at our clinics from January 2006 through March 2010 with 755 nm alexandrite laser (MiniGentleLase, Gentlelase, and GentleMax, Candela). Using patient clinical data and photos that were recorded on a standard side‐effect report chart, we identified patients with suspected urticaria. Those patients were then followed for a period that ranged from 12 to 63 months. Only patients who could be diagnosed, treated, and followed by the dermatologist at our clinics were included in the study. Patients diagnosed or treated by other physicians or nurses and those without clinical photos or insufficient follow‐up data were not included.ResultsWe identified 36 patients who developed a severe, itchy, persistent hive rash on the treated area 6–72 hours after treatment. Eruption occurred most often on the legs (31 cases), followed by the groin (11 cases), axillae (eight cases), forearms (one case), and upper lip (one case). The eruption consisted of a hive rash with multiple pruritic perifollicular papules and confluent plaques on the treated area. Most patients required oral corticosteroids to control the symptoms. Lesions resolved in 7–30 days. The urticaria occurred mostly after the first treatment (26 cases), and was recurrent in subsequent treatments. Pretreating with oral corticosteroids prevented or limited the eruption. Thirty‐three of the 36 patients reported a history of allergic rhinitis or some other allergy. Skin biopsies on four patients showed edema and a deep, dense dermal infiltrate consistent with lymphocytes mixed with eosinophils in a perivascular and occasionally perifollicular pattern in the mid and lower dermis.ConclusionsPersistent urticaria is a rare side effect of laser epilation. Rupture of the hair follicle by laser heat may trigger a delayed hypersensitivity reaction in a subset of predisposed allergic patients. An antigen from the disrupted hair follicle may be the triggering factor. To prevent this side effect, we recommend that laser epilation in allergic patients be preceded by an extended laser patch test, which should be evaluated 24–48 hours later. Preventive prednisone should be prescribed to patients who develop an urticarial rash on the test area. Lasers Surg. Med. 44: 384–389, 2012. © 2012 Wiley Periodicals, Inc.
Pre‐existing fas ligand (FasL) in cancer cells elicits tumor‐specific protective immunity, but delayed induction of FasL expression after inoculation facilitates tumor formation
Authors: Chiu Hsiao‐Ying , Sun Guang‐Huan , Chen Shiow‐Yi , Wang Hsiao‐Hsien , Ho Ming‐Yi , Chu Chia‐Yi , Wu Wan‐Lin , Jhou Ren‐Shiang , Tsai Yi‐Lin , Huang Rui‐Ting , Sun Kuang‐Hui , Tang Shye‐Jye 
Published: April 2012

AbstractOverexpression of Fas ligand (FasL) in cancer cells elicits potential antitumor effects via recruitment of neutrophils. Conversely, FasL‐expressing tumors may counterattack tumor‐infiltrating lymphocytes by delivering apoptotic death signals via Fas/FasL interactions, which may lead to tumor escape. In order to distinguish the role of FasL in antitumor activity and tumor progression, Lewis lung carcinoma cells (LLC‐1) were used to establish the cell line LLC‐FasL, in which FasL expression was repressed by doxycycline (Dox) treatment and induced in the absence of Dox. LLC‐FasL cells promote tumor regression when expressing FasL, whereas tumor outgrowth is observed by depletion of FasL expression. To investigate whether initial expression of FasL during tumor formation is critical for FasL‐mediated tumor regression, Dox‐treated LLC‐FasL cells were inoculated into Dox‐treated mice, but Dox treatment was stopped 5 days after inoculation. When low cell numbers were inoculated, we observed 80% survival and no tumor formation, whereas no mice survived inoculation with high cell numbers, despite the delayed induction of FasL by Dox withdrawal. The inoculation of a high density of cells may establish a favorable tumor microenvironment before the expression of FasL. Our findings demonstrate that FasL may elicit antitumor activity when it is initially present on injected cancer cells and thus can act prior to tumor microenvironment formation. Furthermore, a well‐established tumor microenvironment abrogates FasL‐mediated antitumor activity. © 2012 Wiley Periodicals, Inc.
Pseudo‐continuous arterial spin labeling at 7 T for human brain: Estimation and correction for off‐resonance effects using a Prescan
Authors: Luh Wen‐Ming , Talagala S. Lalith , Li Tie‐Qiang , Bandettini Peter A. 
Published: April 2012

AbstractPseudo‐continuous arterial spin labeling (ASL) can provide best signal‐to‐noise ratio efficiency with a sufficiently long tag at high fields such as 7 T, but it is very sensitive to off‐resonance fields at the tagging location. Here, a robust Prescan procedure is demonstrated to estimate the pseudo‐continuous ASL radiofrequency phase and gradients parameters required to compensate the off‐resonance effects at each vessel location. The Prescan is completed in 1–2 min and is based on acquisition of label/control pair‐wise ASL data as a function of the radiofrequency phase increment applied to the pseudo‐continuous ASL train. It is shown that this approach can be used to acquire high quality whole‐brain pseudo‐continuous ASL perfusion data of the human brain at 7 T. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Coil compression for accelerated imaging with Cartesian sampling
Authors: Zhang Tao , Pauly John M. , Vasanawala Shreyas S. , Lustig Michael 
Published: April 2012

AbstractMRI using receiver arrays with many coil elements can provide high signal‐to‐noise ratio and increase parallel imaging acceleration. At the same time, the growing number of elements results in larger datasets and more computation in the reconstruction. This is of particular concern in 3D acquisitions and in iterative reconstructions. Coil compression algorithms are effective in mitigating this problem by compressing data from many channels into fewer virtual coils. In Cartesian sampling there often are fully sampled k‐space dimensions. In this work, a new coil compression technique for Cartesian sampling is presented that exploits the spatially varying coil sensitivities in these nonsubsampled dimensions for better compression and computation reduction. Instead of directly compressing in k‐space, coil compression is performed separately for each spatial location along the fully sampled directions, followed by an additional alignment process that guarantees the smoothness of the virtual coil sensitivities. This important step provides compatibility with autocalibrating parallel imaging techniques. Its performance is not susceptible to artifacts caused by a tight imaging field‐of‐view. High quality compression of in vivo 3D data from a 32 channel pediatric coil into six virtual coils is demonstrated. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping
Authors: Liu Tian , Wisnieff Cynthia , Lou Min , Chen Weiwei , Spincemaille Pascal , Wang Yi 
Published: April 2012

AbstractQuantitative susceptibility mapping (QSM) opens the door for measuring tissue magnetic susceptibility properties that may be important biomarkers, and QSM is becoming an increasingly active area of scientific and clinical investigations. In practical applications, there are sources of errors for QSM including noise, phase unwrapping failures, and signal model inaccuracy. To improve the robustness of QSM quality, we propose a nonlinear data fidelity term for frequency map estimation and dipole inversion to reduce noise and effects of phase unwrapping failures, and a method for model error reduction through iterative tuning. Compared with the previous phase based linear QSM method, this nonlinear QSM method reduced salt and pepper noise or checkerboard pattern in high susceptibility regions in healthy subjects and markedly reduced artifacts in patients with intracerebral hemorrhages. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Intravoxel incoherent motion MR imaging for prostate cancer: An evaluation of perfusion fraction and diffusion coefficient derived from different b‐value combinations
Authors: Pang Yuxi , Turkbey Baris , Bernardo Marcelino , Kruecker Jochen , Kadoury Samuel , Merino Maria J. , Wood Bradford J. , Pinto Peter A. , Choyke Peter L. 
Published: April 2012

AbstractThere has been a resurgent interest in intravoxel incoherent motion (IVIM) MR imaging to obtain perfusion as well as diffusion information on lesions, in which the diffusion was modeled as Gaussian diffusion. However, it was observed that this diffusion deviated from expected monoexponential decay at high b‐values and the reported perfusion in prostate is contrary to the findings in dynamic contrast‐enhanced (DCE) MRI studies and angiogenesis. Thus, this work is to evaluate the effect of different b‐values on IVIM perfusion fractions (f) and diffusion coefficients (D) for prostate cancer detection. The results show that both parameters depended heavily on the b‐values, and those derived without the highest b‐value correlated best with the results from DCE‐MRI studies; specifically, f was significantly elevated (7.2% vs. 3.7%) in tumors when compared with normal tissues, in accordance with the volume transfer constant (Ktrans; 0.39 vs. 0.18 min−1) and plasma fractional volume (vp; 8.4% vs. 3.4%). In conclusion, it is critical to choose an appropriate range of b‐values in studies or include the non‐Gaussian diffusion contribution to obtain unbiased IVIM measurements. These measurements could eliminate the need for DCE‐MRI, which is especially relevant in patients who cannot receive intravenous gadolinium‐based contrast media. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc.
Preparation and characterization of monodisperse porous silica microspheres with controllable morphology and structure
Authors: He Jie , Yang Chengli , Xiong Xiaohui , Jiang Biwang 
Published: April 2012

AbstractA novel method for the preparation of monodisperse porous silica microspheres with controllable morphology and structure is reported. The starting porous polymer microspheres were first functionalized with ethylenediamine (EDA) to generate amino groups. Subsequently, silica nanoparticles were deposited in the porous polymer microsphere to form polymer/silica hybrid microspheres via a modified sol‐gel process in the presence of tetra‐n‐butylammonium bromide (TBAB) or tetramethyl ammonium hydroxide (TMAH). Upon calcination of the polymer/silica hybrid microspheres, the porous silica microspheres were obtained. The morphology, inner structure, and properties of the porous silica microspheres were studied by field emission scanning electron microscope, Fourier transform infrared spectroscopy, thermogravimetric analysis, and mercury intrusion method. The results show that the presence of TBAB or TMAH in the process not only prevents the agglomeration of the hybrid microspheres, but also governs the controllable morphology from a porous inner structure to a hollow‐cage structure. The obtained porous silica microspheres exhibit no shrinkage from the polymer microspheres with a yield of around 98%. These porous silica microspheres have potential applications in the fields of chromatography, catalyst, and biology. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Interacting nanoparticles with functional surface groups
Authors: Popov Konstantin I. , Nap Rikkert J. , Szleifer Igal , de la Cruz Monica Olvera 
Published: April 2012

AbstractFunctionalized nanoparticles with ionizable groups have generated a large variety of structures with important potential applications in technology. The nature of their interactions is crucial to determining their solubility and to exploring assemblies with diverse symmetries. Here, we use a molecular theory to describe the interactions between two nanoparticles coated with short polymer chains that contain ionizable (functional) end‐groups immersed in aqueous salt solution. It is shown here that the fraction of ionized functional groups in the system depends on factors such as the ionic strength and pH of solution, grafting density of polymer chains, the chain length, as well as the separation distance between the nanoparticles. The interactions between two neighboring nanoparticles influence the charge regulation of the end‐groups, which consequently induces an asymmetric distribution of these charged end‐groups on the nanoparticles, and thus confers a preferred directionality in nanoparticle–nanoparticle interactions. We show that the charge regulating system is less repulsive than an equivalent system with a fixed charge distribution. This is due to a decrease in the charge density of the weak acid end‐groups, to avoid a local increase in counterion confinement (condensation) in the region between neighboring nanoparticles, when their separation decreases. The anisotropic degree of ionization found in our results can be used to design aggregates of nanoparticles with reduced symmetries. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Multifunctional elastomer nanocomposites with functionalized graphene single sheets
Authors: Ozbas Bulent , O'Neill Christopher D. , Register Richard A. , Aksay Ilhan A. , Prud'homme Robert K. , Adamson Douglas H. 
Published: April 2012

AbstractWe demonstrate the use of functionalized graphene sheets (FGSs) as multifunctional nanofillers to improve mechanical properties, lower gas permeability, and impart electrical conductivity for several distinct elastomers. FGS consists mainly of single sheets of crumbled graphene containing oxygen functional groups and is produced by the thermal exfoliation of oxidized graphite (GO). The present investigation includes composites of FGS and three elastomers: natural rubber (NR), styrene–butadiene rubber, and polydimethylsiloxane (PDMS). All of these elastomers show similar and significant improvements in mechanical properties with FGS, indicating that the mechanism of property improvement is inherent to the FGS and not simply a function of chemical crosslinking. The decrease in gas permeability is attributed to the high aspect ratio of the FGS sheets. This creates a tortuous path mechanism of gas diffusion; fitting the permeability data to the Nielsen model yields an aspect ratio of ∼1000 for the FGS. Electrical conductivity is demonstrated at FGS loadings as low as 0.08% in PDMS and reaches 0.3 S/m at 4 wt % loading in NR. This combination of functionalities imparted by FGS is shown to result from its high aspect ratio and carbon‐based structure. © 2012 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2012
Study of simulation method of time evolution in rigged QED
Authors: Ichikawa Kazuhide , Fukuda Masahiro , Tachibana Akitomo 
Published: April 2012

AbstractWe discuss how we formulate time evolution of physical quantities in the framework of the Rigged quantum electrodynamics (QED). The Rigged QED is a theory which has been proposed to treat dynamics of electrons, photons, and atomic nuclei in atomic and molecular systems in a quantum field theoretic way. To solve the dynamics in the Rigged QED, we need different techniques from those developed for the conventional QED. As a first step toward this issue, we propose a procedure to expand the Dirac field operator, which represents electrons, by the electron annihilation/creation operators and solutions of the Dirac equation for electrons in nuclear potential. Similarly, the Schrödinger field operators, which represent atomic nuclei, are expanded by nucleus annihilation/creation operators. Then, we derive time evolution equations for these annihilation and creation operators and discuss how time evolution of the operators for physical quantities can be calculated. In the end, we propose a method to approximate the evolution equations of the operators by the evolution equations for the density matrices of electrons and atomic nuclei. Under this approximation, we carry out numerical simulation of the time evolution of electron charge density of a hydrogen atom. © 2012 Wiley Periodicals, Inc.
Does the H+5 hydrogen cluster exist in dense interstellar clouds?
Authors: Barbatti Mario , Nascimento Marco Antonio Chaer 
Published: April 2012

AbstractThe clustering of hydrogen molecules around a cation in dense interstellar clouds is examined taking into account recent accurate information about the structure and thermochemistry of these clusters. In general, these clustering processes are not important due to the small probability of occurrence of radiative association at low densities. However, the long lived metastable complex (H)* makes the concentration of the H clusters to be of the same order of the concentration of H in these media. This result may have considerable implications for the chemistry of dense interstellar clouds. © 2012 Wiley Periodicals, Inc.
Vibrational enhancement of positron affinities for nonpolar carbon dioxide and carbon disulfide molecules: Multi‐component molecular orbital study for vibrational excited states
Authors: Koyanagi Katsuhiko , Kita Yukiumi , Tachikawa Masanori 
Published: April 2012

AbstractTo demonstrate the binding of a positron to nonpolar CX2 (X = O and S) molecules, we have estimated the vibrational averaged positron affinity (PA) values for the harmonic asymmetric stretching vibrational coordinate with the multi‐component molecular orbital method. A positron can be attached at higher vibrational excitation levels, and vibrational averaged PA values become greater as the number of vibrational quantum number increases. The resultant PA values of carbon disulfide (CS2) molecule are greater than those of CO2, which is consistent with the corresponding property such as infrared (IR) intensity and polarizability of the parent species. © 2012 Wiley Periodicals, Inc.
Inverse sandwich complexes based on low‐valent group 13 elements and cyclobutadiene: A theoretical investigation on E‐C4H4‐E (E = Al, Ga, In, Tl)
Authors: Liu Nan‐Nan , Xu Jing , Ding Yi‐Hong 
Published: April 2012

AbstractThe chemistry of the low‐valent Group 13 elements (E = B, Al, Ga, In, Tl) has formed the recent hot topic. Recently, a series of low‐valent Group 13‐based compounds have been synthesized, i.e., [E‐Cp*‐E]+ (E = Al, Ga, In, Tl) cations, which have been termed as the interesting “inverse sandwich” complexes. To enrich the family of inverse sandwiches, we report our theoretical design of a new type of inverse sandwiches E‐C4H4‐E (E = Al, Ga, In, Tl) for stabilizing the low‐valent Group 13 elements. The calculated dissociation energies indicate that unlike [E‐Cp‐E]+ that dissociates via loss of the charged atom E+, E‐C4H4‐E dissociates via loss of the neutral atom E with the bond strengths of Al > Ga > In > Tl. Moreover, E‐C4H4‐E are more stable in dissociation than [E‐Cp‐E]+ cations. By comparing with other various isomers, we found that the inverted E‐C4H4‐E should be kinetically quite stable with the least conversion barriers of 33.5, 33.5, 35.2, and 36.9 kcal/mol for E = Al, Ga, In, and Tl, respectively. Furthermore, replacement of cyclobutadiene‐H atoms by the highly electron‐positive groups such as SiH3 and Si(CH3)3 could significantly stabilize the inverted form in thermodynamics. Possible synthetic routes are proposed for E‐C4H4‐E. With no need of counterions, the newly designed neutral complexes E‐C4H4‐E welcome future synthesis. © 2012 Wiley Periodicals, Inc.
Nonharmonic vibrational effects in HgClOH: An MP2 Born–Oppenheimer molecular dynamics study
Authors: Ramírez‐Solís Alejandro , Maron Laurent 
Published: April 2012

AbstractWe report a Born–Oppenheimer molecular dynamics study of HgClOH to address the nonharmonic (NH) effects which are important in the development of classical interaction potentials. The electronic structure calculations were performed with the second order Möller–Plesset version of perturbation theory. For the Hg and Cl atoms, the Stuttgart–Dresden relativistic effective core potentials were used with extended‐optimized valence basis, while for O and H the aug‐cc‐pVnZ (n = D,T,Q) basis sets were used. Dynamic effects introduce non‐negligible changes to the equilibrium HgO distance and the ClHgO angle which shows rather large (but still harmonic) variations. The largest NH effects appear for the in‐molecular‐plane HOHg bending and the OH stretching modes. The results for the isolated molecule are relevant to compare the geometrical parameters with the water‐solvated species, both through cluster models or through condensed liquid phase studies. © 2012 Wiley Periodicals, Inc.
The Drosophila midgut: a model for stem cell driven tissue regeneration
Authors: Lucchetta Elena M. , Ohlstein Benjamin 
Published: April 2012

AbstractThe Drosophila and mammalian digestive systems bear striking similarities in genetic control and cellular composition, and the Drosophila midgut has emerged as an amenable model for dissecting the mechanisms of tissue homeostasis. The Drosophila midgut is maintained by multipotent intestinal stem cells (ISCs) that give rise to all cell types in the intestinal epithelium and are required for long‐term tissue homeostasis. ISC proliferation rate increases in response to a myriad of chemical and bacterial insults through the release of JAK‐STAT and EGFR ligands from dying enterocytes that activate the JAK‐STAT and EGFR pathways in ISCs. The Hippo and JNK pathways converge upon JAK‐STAT and EGFR signaling, presumably in response to specific stresses, and JNK and insulin signaling have been shown to be critical in response to age‐related stresses. This review details these emerging mechanisms of tissue homeostasis and the proliferative response of ISCs to epithelial damage, environmental stresses, and aging. WIREs Dev Biol 2012 doi: 10.1002/wdev.51For further resources related to this article, please visit the WIREs website.
DataDesk: an interactive package for data exploration, display, model building, and data analysis
Authors: Velleman Paul F. 
Published: April 2012

AbstractDataDesk is an interactive package for exploration, display, and analysis of data that runs on a variety of desktop computers. Because it has been designed from the ground up for the purpose of data exploration, it incorporates several global design principles not found together in other data analysis software. This article discusses those design principles and illustrates how they lead to innovative approaches to regression model building. WIREs Comput Stat 2012. doi: 10.1002/wics.1208This article is categorized under:

Software for Computational Statistics > Software/Statistical Software
Statistical and Graphical Methods of Data Analysis > Statistical Graphics and Visualization
Statistical and Graphical Methods of Data Analysis > Analysis of High Dimensional Data