bluuebunny/crossref_metadata_2025_split huggingface dataset:
It's Not over When it's Over: Long-Term Symptoms in Cancer Survivors—A Systematic Review
Authors: Harrington Cherise B. , Hansen Jennifer A. , Moskowitz Michal , Todd Briana L. , Feuerstein Michael 
Published: July 2010

Background: The number of cancer survivors is steadily increasing. Following completion of primary cancer treatment and many years thereafter, specific symptoms continue to negatively affect cancer survivors. The purpose of this article is to review the evidence of symptom burden following primary treatment for cancer in survivors of the most common types of cancer (breast, gynecological, prostate, and colorectal). Methods: A systematic review of literature published between the years 2000–2008 that reported late-effects and/or long-term psychosocial symptoms associated with cancer survivorship post-completion of primary cancer treatment was conducted. The symptoms include physical limitations, cognitive limitations, depression/anxiety, sleep problems, fatigue, pain, and sexual dysfunctions. Results: Symptom burden associated with cancer survivorship was consistent among the four most common types of cancer (breast, gynecological, prostate, and rectal/colon), despite various types of treatment exposure. Generally, across the cancer groups, depressive symptoms, pain, and fatigue were commonly found in cancer survivors. Conclusions: Based on longitudinal and cross-sectional evidence, cancer survivors can experience symptoms for more than 10 years following treatment. These symptoms were present in survivors of all four cancer types who underwent a wide variety of treatment. The results indicate that these symptoms should be evaluated and managed to optimize long-term outcomes.
Trade Protection and Industrial Structure
Authors: Albornoz Facundo , Vanin Paolo 
Published: July 2010

Abstract
In a small open economy with heterogeneous firms, in which tariffs determine the mass of active firms, the gains from trade liberalization depend positively on the level of firm vertical heterogeneity (quality heterogeneity) and negatively on transportation costs. The benefits from temporary protection depend on the quality gap: for a given mass of backward firms, the relative gains from protection increase with their quality and decrease with the quality of advanced firms; for given production quality levels, the relative advantage of protection increases with the mass of backward firms.
The Church and Freedom in the Post-modern World
Authors: Dancák Pavol 
Published: July 2010

The Church and Freedom in the Post-modern World
The postmodernism abandons a concept of reality and therefore it avoids the possibility of objective knowledge. The Church opens itself to the whole world without difference and refuses any unilateral alliances because the Church's mission is to spread evangelism to men. Nowadays, very important is defending of man's freedom and protecting freedom from egoism is the actual challenge of these times.
Greek-Catholic Church in Slovakia and its Martyrs
Authors: Petro Marek 
Published: July 2010

Greek-Catholic Church in Slovakia and its Martyrs
The submitted article offers a brief history of the Greek-Catholic Church in Slovakia and processes a topic of the sense and meaning of the martyrdom of blessed Greek-Catholic bishops P. P. Gojdiĉ and V. Hopko. It also highlights the contribution of these blessed men for the ecumenism work.
KdPT, a Tripeptide Derivative of α-Melanocyte–Stimulating Hormone, Suppresses IL-1β–Mediated Cytokine Expression and Signaling in Human Sebocytes
Authors: Mastrofrancesco Arianna , Kokot Agatha , Eberle Alex , Gibbons Nicholas C. J. , Schallreuter Karin U. , Strozyk Elwira , Picardo Mauro , Zouboulis Christos C. , Luger Thomas A. , Böhm Markus 
Published: July 2010

AbstractAcne is the most common inflammatory skin disease in which IL-1 plays a central role. Although α-melanocyte–stimulating hormone has immunomodulatory effects, its usefulness as an anti-inflammatory agent in acne is hampered owing to its lipid- and pigment-inducing effects via activation of melanocortin receptors (MC-Rs). We used the immortalized human sebocyte line SZ95 as an in vitro model to investigate the anti-inflammatory potential of KdPT, a tripeptide derivative of the C-terminal end of α-melanocyte–stimulating hormone. KdPT potently suppressed IL-1β–induced IL-6 and IL-8 expression. Mechanistically, KdPT decreased IL-1β–mediated IκBα degradation, reduced nuclear accumulation of p65, and attenuated DNA binding of NF-κB. Moreover, KdPT reduced IL-1β–mediated generation of intracellular reactive oxygen species, which contributed to IL-1β–mediated cytokine induction. KdPT also reduced cell surface binding of fluorochrome-labeled IL-1β in SZ95 sebocytes. Analysis of the crystal structure of the complex between IL-1β/IL-1R type I (IL-1RI), followed by computer modeling of KdPT and subsequent modeling of the peptide receptor complex with the crystal structure of IL-1RI via manual docking, further predicted that the tripeptide, through several H-bonds and one hydrophobic bond, interacts with the IL-1RI. Importantly, KdPT did not bind to MC-1Rs, as demonstrated by blocking experiments with a peptide analog of Agouti signaling protein and by binding assays using MC-1R–expressing B16 melanoma cells. Accordingly, KdPT failed to induce melanogenesis. Our data demonstrate a promising anti-inflammatory potential of KdPT and point toward novel future directions in the treatment of acne—as well as of various other IL-1–mediated inflammatory diseases—with this small molecule.
NLRC5 Limits the Activation of Inflammatory Pathways
Authors: Benko Szilvia , Magalhaes Joao G. , Philpott Dana J. , Girardin Stephen E. 
Published: July 2010

Abstract
Nod-like receptors (NLRs) are intracellular sentinel proteins that are implicated in the detection of microbes and danger signals, thereby controlling several key innate immune pathways. The human genome encodes 22 NLR proteins, the function of many of which remains unknown. In this study, we present the identification and characterization of NLRC5, a NLR protein whose expression is found predominantly in cells of the myeloid and lymphoid lineages. NLRC5 expression was strongly induced by IFN-γ and more modestly by LPS and polyinosinic:polycytidylic acid. Overexpression of NLRC5 in HEK293T cells resulted in a global dampening of NF-κB–, AP-1–, and type I IFN-dependent signaling, most likely through transcriptional repression. Accordingly, NLRC5 was found to shuttle between the cytosol and the nucleus in a CrmA-dependent manner. Knocking down NLRC5 expression in RAW264.7 murine macrophages resulted in a potent upregulation of the proinflammatory responses to IFN-γ and LPS, including increased secretion of TNF, IL-6, and IL-1β, as well as cell surface expression of CD40. Strikingly, NLRC5 expression was also found to be critical for LPS-induced IL-10 production in RAW264.7 macrophages. Collectively, our results identify NLRC5 as a negative modulator of inflammatory pathways.
Antigen-Containing Liposomes Engrafted with Flagellin-Related Peptides Are Effective Vaccines That Can Induce Potent Antitumor Immunity and Immunotherapeutic Effect
Authors: Faham Abdus , Altin Joseph G. 
Published: July 2010

Abstract
The bacterial protein flagellin can trigger immune responses to infections by interacting with TLR5 on APCs, and Ag-flagellin fusion proteins can act as effective vaccines. We report that flagellin-related peptides containing a His-tag and sequence related to conserved N-motif (aa 85–111) of FliC flagellin, purportedly involved in the interaction of flagellin with TLR5, can be used to target delivery of liposomal Ag to APCs in vitro and in vivo. When engrafted onto liposomes, two flagellin-related peptides, denoted as 9Flg and 42Flg, promoted strong liposome binding to murine bone marrow-derived dendritic cells and CD11c+ splenocytes, and cell binding correlated with expression of TLR5. Liposomes engrafted with 9Flg or 42Flg induced functional MyD88-dependent maturation of dendritic cells in vivo. The vaccination of mice with 9Flg liposomes containing OVA induced OVA-specific T cell priming, increased the number of Ag-responsive IFN-γ–producing CD8+ T cells, and increased Ag-specific IgG1 and IgG2b in serum. Importantly, the vaccination of C57BL/6 mice with syngeneic B16-OVA–derived plasma membrane vesicles, engrafted with 9Flg or 42Flg, potently inhibited tumor growth/metastasis and induced complete tumor regression in the majority of mice challenged with the syngeneic B16-OVA melanoma, in the lung and s.c. tumor models. Strong antitumor responses were also seen in studies using the s.c. P815 tumor model. Therefore, vaccination with Ag-containing liposomes engrafted with 9Flg or 42Flg is a powerful strategy to exploit the innate and adaptive immune systems for the development of potent vaccines and cancer immunotherapies.
Genetic Control of IL-1β Production and Inflammatory Response by the Mouse Irm1 Locus
Authors: Vorraro Francisca , Galvan Antonella , Cabrera Wafa Hanna Koury , Carneiro Patricia Santos , Ribeiro Orlando Garcia , De Franco Marcelo , Starobinas Nancy , Jensen José Ricardo , Seman Michel , Dragani Tommaso A. , Ibañez Olga Célia Martinez 
Published: July 2010

Abstract
Genome-wide linkage analysis using single nucleotide polymorphism arrays was carried out in pedigrees of mice differing in the extent of acute inflammatory response (AIRmax or AIRmin). The AIR phenotype was determined by quantifying the number of infiltrating cells in the 24-h exudate induced by Biogel P-100 s.c. injection and by ex vivo IL-1β production by leukocytes stimulated with LPS and ATP. We mapped the major inflammatory response modulator 1 locus on chromosome 7, at the 1-logarithm of odds (LOD) confidence interval from 116.75 to 139.75 Mb, linked to the number of infiltrating cells (LOD = 3.61) through the production of IL-1β (LOD = 9.35). Of several interesting candidate genes mapping to the inflammatory response modulator 1 locus, 28 of these were differentially expressed in the bone marrow of AIRmax and AIRmin mice. These findings represent a step toward the identification of the genes underlying this complex phenotype.
LL-37 Directs Macrophage Differentiation toward Macrophages with a Proinflammatory Signature
Authors: van der Does Anne M. , Beekhuizen Henry , Ravensbergen Bep , Vos Tim , Ottenhoff Tom H. M. , van Dissel Jaap T. , Drijfhout Jan W. , Hiemstra Pieter S. , Nibbering Peter H. 
Published: July 2010

Abstract
The human cathelicidin LL-37 has broad-spectrum antimicrobial activity. It also participates at the interface of innate and adaptive immunity by chemoattracting immune effector cells, modulating the production of a variety of inflammatory mediators by different cell types, and regulating the differentiation of monocytes into dendritic cells. In this study, we investigated the effects of LL-37 on the differentiation of human monocytes into anti-inflammatory macrophages (MΦ-2; driven by M-CSF) versus proinflammatory macrophages (MΦ-1; driven by GM-CSF) as well as on fully differentiated MΦ-1 and MΦ-2. Results revealed that monocytes cultured with M-CSF in the presence of LL-37 resulted in macrophages displaying a proinflammatory signature, namely, low expression of CD163 and little IL-10 and profound IL-12p40 production on LPS stimulation. The effects of LL-37 on M-CSF-driven macrophage differentiation were dose- and time-dependent with maximal effects observed at 10 μg/ml when the peptide was present from the start of the cultures. The peptide enhanced the GM-CSF–driven macrophage differentiation. Exposure of fully differentiated MΦ-2 to LL-37 for 6 d resulted in macrophages that produced less IL-10 and more IL-12p40 on LPS stimulation than control MΦ-2. In contrast, LL-37 had no effect on fully differentiated MΦ-1. Peptide mapping using a set of 16 overlapping 22-mer peptides covering the complete LL-37 sequence revealed that the C-terminal portion of LL-37 is responsible for directing macrophage differentiation. Our results furthermore indicate that the effects of LL-37 on macrophage differentiation required internalization of the peptide. Together, we conclude that LL-37 directs macrophage differentiation toward macrophages with a proinflammatory signature.
Poly(ADP-Ribose) Polymerase-1 Is a Determining Factor in Crm1-Mediated Nuclear Export and Retention of p65 NF-κB upon TLR4 Stimulation
Authors: Zerfaoui Mourad , Errami Youssef , Naura Amarjit S. , Suzuki Yasuhiro , Kim Hogyoung , Ju Jihang , Liu Tao , Hans Chetan P. , Kim Jong G. , Abd Elmageed Zakaria Y. , Koochekpour Shahriar , Catling Andrew , Boulares A. Hamid 
Published: July 2010

Abstract
The role of NF-κB in the expression of inflammatory genes and its participation in the overall inflammatory process of chronic diseases and acute tissue injury are well established. We and others have demonstrated a critical involvement of poly(ADP-ribose) polymerase (PARP)-1 during inflammation, in part, through its relationship with NF-κB. However, the mechanism by which PARP-1 affects NF-κB activation has been elusive. In this study, we show that PARP-1 inhibition by gene knockout, knockdown, or pharmacologic blockade prevented p65 NF-κB nuclear translocation in smooth muscle cells upon TLR4 stimulation, NF-κB DNA-binding activity, and subsequent inducible NO synthase and ICAM-1 expression. Such defects were reversed by reconstitution of PARP-1 expression. PARP-1 was dispensable for LPS-induced IκBα phosphorylation and subsequent degradation but was required for p65 NF-κB phosphorylation. A perinuclear p65 NF-κB localization in LPS-treated PARP-1−/− cells was associated with an export rather an import defect. Indeed, whereas PARP-1 deficiency did not alter expression of importin α3 and importin α4 and their cytosolic localization, the cytosolic levels of exportin (Crm)-1 were increased. Crm1 inhibition promoted p65 NF-κB nuclear accumulation as well as reversed LPS-induced p65 NF-κB phosphorylation and inducible NO synthase and ICAM-1 expression. Interestingly, p65 NF-κB poly(ADP-ribosyl)ation decreased its interaction with Crm1 in vitro. Pharmacologic inhibition of PARP-1 increased p65 NF-κB–Crm1 interaction in LPS-treated smooth muscle cells. These results suggest that p65 NF-κB poly(ADP-ribosyl)ation may be a critical determinant for the interaction with Crm1 and its nuclear retention upon TLR4 stimulation. These results provide novel insights into the mechanism by which PARP-1 promotes NF-κB nuclear retention, which ultimately can influence NF-κB–dependent gene regulation.
The Mannose Receptor Mediates the Uptake of Diverse Native Allergens by Dendritic Cells and Determines Allergen-Induced T Cell Polarization through Modulation of IDO Activity
Authors: Royer Pierre-Joseph , Emara Mohamed , Yang Chaoxing , Al-Ghouleh Abeer , Tighe Paddy , Jones Nick , Sewell Herb F. , Shakib Farouk , Martinez-Pomares Luisa , Ghaemmaghami Amir M. 
Published: July 2010

Abstract
The mannose receptor (MR) is a C-type lectin expressed by dendritic cells (DCs). We have investigated the ability of MR to recognize glycosylated allergens. Using a gene silencing strategy, we have specifically inhibited the expression of MR on human monocyte-derived DCs. We show that MR mediates internalization of diverse allergens from mite (Der p 1 and Der p 2), dog (Can f 1), cockroach (Bla g 2), and peanut (Ara h 1) through their carbohydrate moieties. All of these allergens bind to the C-type lectin-like carbohydrate recognition domains 4–7 of MR. We have also assessed the contribution of MR to T cell polarization after allergen exposure. We show that silencing MR expression on monocyte-derived DCs reverses the Th2 cell polarization bias, driven by Der p 1 allergen exposure, through upregulation of IDO activity. In conclusion, our work demonstrates a major role for MR in glycoallergen recognition and in the development of Th2 responses.
Antibiotic susceptibility pattern of rapidly growing mycobacteria
Authors: Gayathri R , Therese K Lily , Deepa P , Mangai S , Madhavan HN 
Published: July 2010

Background:
The rapidly growing mycobacteria (RGM) causing human infections primarily consist of the Mycobacterium fortuitum group, Mycobacterium abscessus and Mycobacterium chelonae. The antibiotic susceptibility testing is important to determine the appropriate therapy as the antibiotics used to treat RGM are different from those used for treating infections caused by slow growers of mycobacteria.

Aim:
To determine antibiotic susceptibility of RGM using Kirby Bauer method and following Clinical and Laboratory Standards Institute (CLSI) guidelines.

Settings and Design:
Larsen and Toubro Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, Retrospective study.

Materials and Methods:
The antibiotic susceptibility testing was performed following CLSI method for the drugs Amikacin, Azithromycin, Tobramycin, Ceftazidime, Cephotaxime, Cefuroxime, Cefaperazone, Ceftriaxone, Ciprofloxacin, Ofloxacin, Norfloxacin, Gatifloxacin and Moxifloxacin.

Results and Conclusions:
Out of the 148 RGM isolates 146 (98%) were susceptible to amikacin, 138 (91%) to gatifloxacin, 132 (87%) to moxifloxacin, 122 (76%) to ciprofloxacin and 116 (74%) to Norfloxacin. Majority of the RGM were resistant to Ceftazidime, Cephotaxime and Cefaperazone. All the M. abscessus isolates were resistant to tobramycin. The in vitro antibiotic susceptibility testing by disc diffusion method showed that majority of the RGM were sensitive to Amikacin followed by Gatifloxacin, Moxifloxacin and Ciprofloxacin
Predicting Net Discount Rates: A Comparison of Professional Forecasts, Time-series Forecasts and Traditional Methods
Authors: Cushing Matthew J. , Rosenbaum David I. 
Published: July 2010

AbstractPrevious research proposed two future net discount rate estimators that improved on naïve long-term average and random walk estimators. The proposed estimators were superior in the class of estimators that used only current and past observations on net discount rates. In this paper we consider two extensions. First we examine whether professional forecasts perform significantly better than the two alternatives. Second, we examine the properties and performance of multivariate estimators that account for the potentially differing time-series behaviors of the underlying wage growth and interest rate series.
Discounting Damage Awards Using the Zero Coupon Treasury Curve: Satisfying Legal and Economic Theory While Matching Future Cash Flow Projections
Authors: Rosenberg Joseph Irving 
Published: July 2010

Abstract
How to calculate damage awards has long been the subject of academic dispute. Much focus has been on what is the appropriate discount rate to convert future lost earnings into a lump sum amount. Conflicting or ambiguous legal guidance by the courts has lead to wide disparities in discount rate methodology. This paper presents a fresh, alternative approach to valuing lost earnings in damage awards using current market data from the zero coupon Treasury bond curve. Unlike many other approaches this approach satisfies legal requirements while offering several theoretical and practical benefits: (a) default free discounting; (b) market-based prices and yields; (c) a fully objective way to recompute awards if market conditions change materially in the course of litigation; (d) satisfaction of the “parity in risk” principal which requires consistent treatment of uncertainty in cash flows and discount rate, which is violated by using an arbitrary average of three-month T-bill rates if inflation is embedded in lost earnings; and (e) a theoretically investible stream of cash flows that can be maturity matched against projected lost earnings.
A Supplement to “Assessing Economic Damages in Personal Injury and Wrongful Death Litigation: The State of South Dakota”
Authors: Langelett George , Fausti Scott 
Published: July 2010

Abstract
In the Fall 2007 issue of the Journal of Forensic Economics Ralph J. Brown and Erik L. Olsen outline case law relevant for forensic economics in the areas of personal injury and wrongful death litigation in the State of South Dakota. This note supplements Brown's and Olsen's work by discussing three additional issues of which readers should be aware before practicing forensic economics in the State of South Dakota. These issues are: the statutory pre-judgment interest rate, the required discount rate in workmen's compensation cases, and the statutory increase in compensation in workmen's compensation cases.
Assessing Economic Damages in Personal Injury and Wrongful Death Litigation: The State of Alaska
Authors: Taylor Laura J. 
Published: July 2010

AbstractIn contribution to the series on economic damages in personal injury and wrongful death cases by state, this article presents the legal framework for calculating economic damages in civil litigation in the State of Alaska. Areas of discussion include the court system in Alaska, the requirements for an economic expert in the discovery process, earnings calculations and the related deductions in personal injury and wrongful death matters. In addition, non-economic damages are briefly addressed, as are subsistence activities and the Permanent Fund Dividend.
Assessing Economic Damages in Personal Injury and Wrongful Death Litigation: The State of New Jersey
Authors: Tinari Frank D. , Kucsma Kristin K. 
Published: July 2010

AbstractContributors to the Journal of Forensic Economics are compiling a state-by-state series of papers on how economic damages are assessed in personal injury and wrongful death cases. This paper discusses rules of the court, the court system, and case law for the State of New Jersey. Overall, New Jersey is both different and the same as many other states. The court requires experts to discount to present value, use gender-neutral life expectancy tables, and subtract personal income taxes when estimating earnings losses. New Jersey also accepts expert testimony regarding the value of lost companionship services and advice and counsel services in death cases. This paper discusses these issues and others, with a goal of familiarizing forensic economists with the relevant court rules and rulings and standard practices when performing economic damage appraisals in the State of New Jersey.
Long‐term results of single‐agent thalidomide as initial therapy for asymptomatic (smoldering or indolent) myeloma
Authors: Detweiler‐Short Kristen , Hayman Suzanne , Gertz Morie A. , Lacy Martha Q. , Dispenzieri Angela , Kumar Shaji , Zeldenrust Steven R. , Russell Stephen J. , Lust John A. , Kyle Robert A. , Greipp Philip R. , Witzig Thomas E. , Vincent Rajkumar S. 
Published: July 2010

AbstractWe report the long‐term follow‐up results of a phase II trial of thalidomide for early‐stage multiple myeloma (MM). Patients were eligible if they had smoldering multiple myeloma (SMM) or indolent MM without the need for immediate therapy. Thalidomide was initiated at a dose of 200 mg/day and adjusted as tolerated. Disease progression was defined using modified American Society of Hematology/Food and Drug Administration consensus panel criteria for SMM. Thirty‐one patients were enrolled; 29 (19 SMM and 10 indolent MM) were eligible. The median age was 61 years. Median follow‐up of living patients was 10.2 years (range, 7.5‐11.0 years). Ten patients (34%) had a partial response (PR) and nine had minimal response (MR) for an MR plus PR rate of 66%. The median time to progression (TTP) to symptomatic myeloma was 35 months. Median TTP was 61 months in those achieving PR, 39 months with MR, and 9 months among those failing to achieve either MR or PR, P = 0.005. Median overall survival from diagnosis was 86 months; median survival from onset of symptomatic myeloma was 49 months. Grade 3‐4 nonhematologic adverse events were noted in 55% of patients. Randomized trials are needed to determine the role of early therapy in SMM. Am. J. Hematol., 2010. © 2010 Wiley‐Liss, Inc.