bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review on performance characteristics of FNA of renal lesions: It is time for a standardized classification system
Authors: Katipoglu Kübra , Kilic Irem , Kurtulan Olcay , Akdas Yasemin , Barkan Güliz A. 
Published: May 2024

AbstractBackgroundThe incidence of renal tumors has steadily increased over the past decade. In this study, the authors performed a systematic review and analysis of the literature on renal fine‐needle aspiration (FNA) to determine its performance and explore whether a standardized classification system can be used for reporting renal FNA cytology.MethodsA systematic search of published articles on renal FNA was conducted. The data on FNA and histologic diagnosis were extracted and categorized, and the risk of malignancy was calculated. Different scenarios were used to estimate FNA performance statistics.ResultsOf the 3766 potentially relevant studies, 23 met the inclusion criteria of the study. The 2231 FNA cases included were re‐categorized according to the classification system, rendering 142 (6.36%) nondiagnostic, 270 (12.1%) nonneoplastic, 271 (12.14%) benign neoplasm, 65 (2.91%) renal neoplasm with unknown malignant potential, oncocytic type, 25 (1.12%) atypia of undetermined significance, 60 (2.68%) suspicious for malignancy, and 1398 (62.66%) malignant FNA diagnoses. The risk of malignancy in these cases was 65.4%, 18.1%, 16.6%, 16.9%, 60%, 73.3%, and 96.9%, respectively. According to the classification system, the study indicated that the accuracy of renal FNA was between 91% and 95%, the sensitivity was 90.9%–96.7%, and the specificity was 82%–92% in different scenarios.ConclusionsThere is a need for a standardized reporting in renal cytology that will improve the sensitivity and accuracy of renal cytology, reduce the rate of indeterminate diagnoses, and alter the management strategies of renal lesions. Based on the available literature, a new reporting system is proposed, including categories with an associated risk of malignancy.
Statins as anti‐tumor agents: A paradigm for repurposed drugs
Authors: Tripathi Sneha , Gupta Ekta , Galande Sanjeev 
Published: May 2024

AbstractBackgroundStatins, frequently prescribed medications, work by inhibiting the rate‐limiting enzyme HMG‐CoA reductase (HMGCR) in the mevalonate pathway to reduce cholesterol levels. Due to their multifaceted benefits, statins are being adapted for use as cost‐efficient, safe and effective anti‐cancer treatments. Several studies have shown that specific types of cancer are responsive to statin medications since they rely on the mevalonate pathway for their growth and survival.Recent FindingsStatin are a class of drugs known for their potent inhibition of cholesterol production and are typically prescribed to treat high cholesterol levels. Nevertheless, there is growing interest in repurposing statins for the treatment of malignant neoplastic diseases, often in conjunction with chemotherapy and radiotherapy. The mechanism behind statin treatment includes targeting apoptosis through the BCL2 signaling pathway, regulating the cell cycle via the p53‐YAP axis, and imparting epigenetic modulations by altering methylation patterns on CpG islands and histone acetylation by downregulating DNMTs and HDACs respectively. Notably, some studies have suggested a potential chemo‐preventive effect, as decreased occurrence of tumor relapse and enhanced survival rate were reported in patients undergoing long‐term statin therapy. However, the definitive endorsement of statin usage in cancer therapy hinges on population based clinical studies with larger patient cohorts and extended follow‐up periods.ConclusionsThe potential of anti‐cancer properties of statins seems to reach beyond their influence on cholesterol production. Further investigations are necessary to uncover their effects on cancer promoting signaling pathways. Given their distinct attributes, statins might emerge as promising contenders in the fight against tumorigenesis, as they appear to enhance the efficacy and address the limitations of conventional cancer treatments.
Computational and Spectroscopic Studies on the Formation of Halogen‐Bonded Complexes Between Tertiary Amines and CBr4 and Application in the Light‐Mediated Amino Acid Coupling
Authors: Routsi E. Alexandros , Mantzourani Christiana , Rrapi Marie , Mountanea Olga G. , Kokotou Maroula G. , Tzeli Demeter , Kokotos Christoforos G. , Kokotos George 
Published: May 2024

AbstractIn recent years, halogen‐bonded complexes (XBCs), in solution, have played a pivotal role in inducing photochemical organic reactions. In this work, we explore the ability of various tertiary amines to act as XB acceptors in the presence of the XB donor CBr4 by computational and spectroscopic studies. DFT studies clearly showcase the formation of XBCs between the studied tertiary amines and CBr4. Simultaneously, computational and experimental UV‐Vis studies display intense red shifts that are consistent with charge transfer observed from tertiary amines to CBr4. A detailed NMR study revealed a clear chemical shift of the carbon carrying the bromine atoms upon mixing the XB acceptor with the donor, suggesting that this spectroscopic technique is indeed an experimental tool to identify the generation of XBCs. An application of the ability of such XBCs to activate a carboxylic acid under UVA irradiation or sunlight is presented for amino acid coupling. Among the various tertiary amines studied, the pair DABCO‐CBr4 was found to work well for the photochemical amide bond formation. Direct infusion‐HRMS studies allowed us to propose a general mechanism for the photochemical amino acid coupling in the presence of a tertiary amine and CBr4, initiated by the photoactivation of an XBC.
Solution Dynamics of Covalent Open‐[60]Fullerene Dimers
Authors: Okamoto Shu , Hashikawa Yoshifumi , Murata Yasujiro 
Published: May 2024

AbstractThe translational diffusivity of covalent open‐[60]fullerene dimers in an organic solvent was found to be well describable by a prolate ellipsoid model while a monomeric open‐[60]fullerene behaves like a sphere model. The water association dynamics were examined for two open‐[60]fullerene dimers, showing a higher water affinity for the sp3‐linked dimer relative to sp2‐linked dimer owing to an effective orbital–orbital overlap identified by π(fullerene)→σ*(H2O) interactions as suggested by theoretical calculations.
Fuzzy inference logic assisted rendezvous points based effective routing strategy in wireless sensor networks
Authors: Chakraborty Sujay , Raghuvanshi Ajay Singh 
Published: May 2024

SummaryIn this proposed strategy, an effective routing strategy is introduced for routing based on Rendezvous Points assisted fuzzy inference logics. First, sensor nodes in the cluster are created using the mean‐shift clustering mechanism (MS‐ClusT). A cluster head is selected for the clusters to gather aggregated data from the nodes of clusters. The cluster head selection is done using the Manta Ray optimization‐assisted modified network‐based fuzzy inference logic (MMFiL) approach. Rendezvous points are then selected for routing to minimize the delay and energy consumption for visiting all cluster heads. The rendezvous points are used to define the shortest route for routing. The shortest path from clusters to the base station by selecting rendezvous points is implemented using an integrated neural network with an Archer‐Fish optimization algorithm (InnAFo). In the end, the performance attained by the model is compared with the results of the classical strategy and returns a 0.976563 packet delivery rate and 0.029297 loss rate in 500 nodes. Furthermore, the throughput attained by the proposed model is 0.992874 Mbps, and the delay is 67.30 ms at 500 nodes. The analysis of the proposed model will result in less time needed for cluster head selection.
Impounded sediment and dam removal: Erosion rates and proximal downstream fate
Authors: Collins Mathias J. , Baker Matthew E. , Cashman Matthew J. , Miller Andrew , Van Ryswick Stephen 
Published: May 2024

AbstractSediment management is an important aspect of dam removal projects, often driving costs and influencing community acceptance. For dams storing uncontaminated sediments, downstream release is often the cheapest and most practical approach and can be ecologically beneficial to downstream areas deprived of sediment for years. To employ this option, project proponents must estimate the sediment quantity to be released and, if substantial, estimate how long it will take to erode, where it will go and how long it will stay there. We investigated these issues when the Bloede Dam was removed from the Patapsco River in Maryland, USA, in 2018. The dam was about 10 m high, and its impoundment was nearly filled with an estimated 186 600 m3 of sediment composed of 70% sand and 30% mud. After removal, using elevation surveys generated by traditional methods as well as structure‐from‐motion (SfM) photogrammetry at high temporal resolution, we documented rapid erosion of stored sediments in the first 6 months (~60%) followed by greatly reduced erosion rates for the next two and a half years. A stable channel developed in the impoundment during the rapid erosion phase. These results were predicted by a two‐phased erosion response model developed from observations at sand‐filled impoundments, thus expanding its applicability to include impoundments with a sand‐over‐mud stratigraphy. A similar two‐phase erosion response has been reported for sediment releases at other dam removals in the United States, France and Japan across a range of dam and watershed scales, indicating what practitioners and communities should expect in similar settings. Downstream, repeat surveys combined with discharge and sediment gaging showed rapid transport of eroded sediments through a 5‐km reach, especially during the first year when discharges were above normal, and little overbank storage.
Preliminary exploration of acceptance and emotional responses to the key floral volatile compounds of Pu'er crude tea
Authors: An Huimin , Ou Xingchang , Chen Jinhua , Li Juan , Li Shi , Liu Yang , Jiang Hongjian , Li Chongxing , Fang Linjiang , Liu Zhonghua , Huang Jianan 
Published: May 2024

AbstractPu'er crude tea (PCT), the initial raw material for making Pu'er tea, is favored because of unique flavor and health effects. Emotional response is helpful to explain consumers’ choice of different flavors of tea. This study aims to clarify the key floral volatiles of PCT and their emotional impact on people. Twenty‐nine compounds were identified as the key volatiles from 237 volatiles, which formed the flowery aroma of PCT. Linalool, geraniol, nonanal, and methyl salicylate were more abundant in the PCT, they evoked the top five emotions (mild, wild, aggressive, tame, bored). Methyl salicylate contributed most to the wild emotion in the two mixed samples (B10 and B14), and it may contribute positively to the health effects of tea, such as refreshing and anti‐inflammatory. This study provided a preliminary research idea for exploring the relationship between tea aroma and human emotions and its potential role in human health.
Effect of tea green leafhopper (Empoasca onukii Matsuda) sucking on the quality of Oriental Beauty
Authors: Zeng Lin , Liu Yu‐Yi , Wang Fang , Jin Shan , Chen Lian‐Shuang , Fu Yan‐Qing , Feng Zhi‐Hui , Yin Jun‐Feng , Sun Wei‐Jiang , Yu Xiao‐Min , Xu Yong‐Quan 
Published: May 2024

AbstractThis study aimed to investigate the effects of tea green leafhopper damage on the sensory quality and metabolite composition of Oriental Beauty by using tea leaves from different varieties of tea plants and processing factories. The results indicated that tea green leafhopper damage could reduce bitterness and increase the level of fruity aroma, which was related to the content changes of catechin components and alcohol substances. Furthermore, the tea green leafhopper salivary treatment experiment revealed that the decrease of catechin content and increase of theaflavin content were mainly influenced by the action of saliva and mechanical injury, and changes in volatile components such as linalool oxidation were responsible for the alteration in aroma. These findings provide a theoretical reference for the aroma formation and quality improvement of Oriental Beauty.
Government subsidies and corporate environmental, social and governance performance: Evidence from companies of China
Authors: Peng Pei , Sun Mengzi 
Published: May 2024

AbstractEnvironmental, social, and governance (ESG) performance is crucial for companies to attain sustainable development, which is a key reference for assessing the value and growth potential of a company. Government subsidies can provide incentives for companies to prioritize environmental preservation, meet their social duties, and improve their governance performance. This paper empirically examines the effects and mechanisms of government subsidies on corporate ESG performance, using an Ologit multiple ordered regression model based on data from Chinese listed companies. We find that not only do total government subsidies significantly improve firms' ESG performance, but both environmental and non‐environmental subsidies also have the similar effect, albeit with different impact mechanisms. The analysis of the mechanism suggests that government subsidies can enhance corporate ESG performance by promoting green innovation, alleviating financing constraints, increasing charitable donations, and attracting social attention. This paper holds significant practical value as it presents empirical findings as a basis for reforming China's subsidy policies, showcasing the actual impact of diverse subsidy policies and the heterogeneity.
Neonatal immune stimulation results in sex‐specific changes in ultrasonic vocalizations but does not affect seizure susceptibility in neonatal mice
Authors: Santana‐Coelho Danielle , Pranske Zachary J. , Nolan Suzanne O. , Hodges Samantha L. , Binder Matthew S. , Womble Paige D. , Narvaiz David A. , Muhammad Ilyasah , Lugo Joaquin N. 
Published: May 2024

AbstractNeuroinflammation during the neonatal period has been linked to disorders such as autism and epilepsy. In this study, we investigated the early life behavioral consequences of a single injection of lipopolysaccharide (LPS) at postnatal day 10 (PD10) in mice. To assess deficits in communication, we performed the isolation‐induced ultrasonic vocalizations (USVs) test at PD12. To determine if early life immune stimulus could alter seizure susceptibility, latency to flurothyl‐induced generalized seizures was measured at 4 hours (hrs), 2 days, or 5 days after LPS injections. LPS had a sex‐dependent effect on USV number. LPS‐treated male mice presented significantly fewer USVs than LPS‐treated female mice. However, the number of calls did not significantly differ between control and LPS for either sex. In male mice, we found that downward, short, and composite calls were significantly more prevalent in the LPS treatment group, while upward, chevron, and complex calls were less prevalent than in controls (p < 0.05). Female mice that received LPS presented a significantly higher proportion of short, frequency steps, two‐syllable, and composite calls in their repertoire when compared with female control mice (p < 0.05). Seizure latency was not altered by early‐life inflammation at any of the time points measured. Our findings suggest that early‐life immune stimulation at PD10 disrupts vocal development but does not alter the susceptibility to flurothyl‐induced seizures during the neonatal period. Additionally, the effect of inflammation in the disruption of vocalization is sex‐dependent.
Head‐to‐head comparison of relevant cell sources of small extracellular vesicles for cardiac repair: Superiority of embryonic stem cells
Authors: González‐King Hernán , Rodrigues Patricia G. , Albery Tamsin , Tangruksa Benyapa , Gurrapu Ramya , Silva Andreia M. , Musa Gentian , Kardasz Dominika , Liu Kai , Kull Bengt , Åvall Karin , Rydén‐Markinhuhta Katarina , Incitti Tania , Sharma Nitin , Graneli Cecilia , Valadi Hadi , Petkevicius Kasparas , Carracedo Miguel , Tejedor Sandra , Ivanova Alena , Heydarkhan‐Hagvall Sepideh , Menasché Phillipe , Synnergren Jane , Dekker Niek , Wang Qing‐Dong , Jennbacken Karin 
Published: May 2024

AbstractSmall extracellular vesicles (sEV) derived from various cell sources have been demonstrated to enhance cardiac function in preclinical models of myocardial infarction (MI). The aim of this study was to compare different sources of sEV for cardiac repair and determine the most effective one, which nowadays remains limited. We comprehensively assessed the efficacy of sEV obtained from human primary bone marrow mesenchymal stromal cells (BM‐MSC), human immortalized MSC (hTERT‐MSC), human embryonic stem cells (ESC), ESC‐derived cardiac progenitor cells (CPC), human ESC‐derived cardiomyocytes (CM), and human primary ventricular cardiac fibroblasts (VCF), in in vitro models of cardiac repair. ESC‐derived sEV (ESC‐sEV) exhibited the best pro‐angiogenic and anti‐fibrotic effects in vitro. Then, we evaluated the functionality of the sEV with the most promising performances in vitro, in a murine model of MI‐reperfusion injury (IRI) and analysed their RNA and protein compositions. In vivo, ESC‐sEV provided the most favourable outcome after MI by reducing adverse cardiac remodelling through down‐regulating fibrosis and increasing angiogenesis. Furthermore, transcriptomic, and proteomic characterizations of sEV derived from hTERT‐MSC, ESC, and CPC revealed factors in ESC‐sEV that potentially drove the observed functions. In conclusion, ESC‐sEV holds great promise as a cell‐free treatment for promoting cardiac repair following MI.
Morphological variation of tail bone among two chicken breeds and their F1 progeny
Authors: Nyirimana Prudence , Kondoh Daisuke , Tomiyasu Jumpei , Watanabe Momoka , Okada Yume , Nishida Yuma , Goto Tatsuhiko 
Published: May 2024

AbstractFancy breeds of Japanese indigenous chicken display extensive morphological diversity, particularly in tail feathers. Although marked differences in tail and bone traits have been reported between Tosa‐jidori (wild type) and Minohikichabo (rich type) breeds, little is known about the pattern of genetic inheritance in cross experiments. Therefore, this study aimed to investigate the strain and sex effects, and inheritance patterns, in the morphometric variation of pygostyle bones among Tosa‐jidori, Minohikichabo, and their F1 hybrids. Five morphological traits, angle of the apex of the pygostyle, pygostyle length, margo cranialis length, tail feather number, and body weight, were evaluated at the adult stage. A significant strain difference was detected in all traits, whereas significant sex differences were observed in only three traits, but not in the angle of the apex of the pygostyle and tail feather number. In F1 hybrids, the angle of the apex of the pygostyle was significantly different to that of Tosa‐jidori but not that of Minohikichabo, whereas the pygostyle length and tail number of F1 hybrids were significantly different from those of Minohikichabo but not those of Tosa‐jidori. A significant heterosis effect was found in the margo cranialis length and body weight. All five traits showed nonadditive inheritance patterns but varied in each trait between partial dominance (angle of the apex of pygostyle), full dominance (pygostyle length and tail feather number), and over‐dominance (margo cranialis length and body weight). Interestingly, different patterns of genetic inheritance in the F1 hybrid were observed at different locations, even within the same pygostyle bone. Using the Japanese indigenous chicken model, these results provide a substantial step toward understanding the genetic architecture of morphology in chickens.
The burden of infectious diseases throughout and after the COVID‐19 pandemic (2020–2023) and Russo‐Ukrainian war migration
Authors: Rzymski Piotr , Zarębska‐Michaluk Dorota , Parczewski Miłosz , Genowska Agnieszka , Poniedziałek Barbara , Strukcinskiene Birute , Moniuszko‐Malinowska Anna , Flisiak Robert 
Published: May 2024

AbstractUnderstanding how the infectious disease burden was affected throughout the COVID‐19 pandemic is pivotal to identifying potential hot spots and guiding future mitigation measures. Therefore, our study aimed to analyze the changes in the rate of new cases of Poland's most frequent infectious diseases during the entire COVID‐19 pandemic and after the influx of war refugees from Ukraine. We performed a registry‐based population‐wide study in Poland to analyze the changes in the rate of 24 infectious disease cases from 2020 to 2023 and compared them to the prepandemic period (2016–2019). Data were collected from publicly archived datasets of the Epimeld database published by national epidemiological authority institutions. The rate of most of the studied diseases (66.6%) revealed significantly negative correlations with the rate of SARS‐CoV‐2 infections. For the majority of infectious diseases, it substantially decreased in 2020 (in case of 83%) and 2021 (63%), following which it mostly rebounded to the prepandemic levels and, in some cases, exceeded them in 2023 when the exceptionally high annual rates of new cases of scarlet fever, Streptococcus pneumoniae infections, HIV infections, syphilis, gonococcal infections, and tick‐borne encephalitis were noted. The rate of Clostridioides difficile enterocolitis was two‐fold higher than before the pandemic from 2021 onward. The rate of Legionnaires’ disease in 2023 also exceeded the prepandemic threshold, although this was due to a local outbreak unrelated to lifted COVID‐19 pandemic restrictions or migration of war refugees. The influx of war migrants from Ukraine could impact the epidemiology of sexually transmitted diseases. The present analysis indicates that continued efforts are needed to prevent COVID‐19 from overwhelming healthcare systems again and decreasing the control over the burden of other infectious diseases. It also identifies the potential tipping points that require additional mitigation measures, which are also discussed in the paper, to avoid escalation in the future.
Period prevalence of uveitis in human T‐lymphotropic virus 1 carriers versus noncarriers in a highly endemic area: The Nagasaki Islands Study
Authors: Miyata Jun , Yamanashi Hirotomo , Dake Yoshinori , Nobusue Kenichi , Doi Yusuke , Honda Yukiko , Nonaka Fumiaki , Arima Kazuhiko , Tamai Mami , Sasaki Daisuke , Shimizu Yuji , Hasegawa Hiroo , Kitaoka Takashi , Yanagihara Katsunori , Aoyagi Kiyoshi , Kawakami Atsushi , Maeda Takahiro 
Published: May 2024

AbstractThe magnitude of the effect of human T‐lymphotropic virus 1 (HTLV‐1) infection on uveitis remains unclear. We conducted a cross‐sectional study in a highly endemic area of HTLV‐1 in Japan. The study included 4265 residents (men, 39.2%), mostly middle‐aged and older individuals with a mean age of 69.9 years, who participated in our surveys between April 2016 and September 2022. We identified HTLV‐1 carriers by screening using chemiluminescent enzyme immunoassays and confirmatory tests, and the proportion of carriers was 16.1%. Participants with uveitis were determined from the medical records of all hospitals and clinics where certified ophthalmologists practiced. We conducted logistic regression analyses in an age‐ and sex‐adjusted model to compute the odds ratio (OR) and 95% confidence interval (CI) of uveitis according to HTLV‐1 infection status. Thirty‐two (0.8%) participants had uveitis. For HTLV‐1 carriers, the age‐ and sex‐adjusted OR (95% CI) of uveitis was 3.27 (1.57–6.72) compared with noncarriers. In conclusion, HTLV‐1 infection was associated with a higher risk of uveitis among mostly middle‐aged and older Japanese residents in a highly endemic HTLV‐1 area. Our findings suggest that physicians who treat HTLV‐1 carriers should assess ocular symptoms, and those who diagnose patients with uveitis should consider HTLV‐1 infection.