bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐Term Outcome After Catheter Ablation for Left Posterior Fascicular Ventricular Tachycardia Without Development of Left Posterior Fascicular Block
Authors: WISSNER ERIK , MENON S YAMKUMAR DIVAKARA , METZNER ANDREAS , SCHOONDERWOERD BAS , NUYENS DIETER , MAKIMOTO HISAKI , ZHANG QINGYING , MATHEW SHIBU , FUERNKRANZ ALEXANDER , RILLIG ANDREAS , TILZ ROLAND RICHARD , KUCK KARL‐HEINZ , OUYANG FEIFAN 
Published: May 2012

Long‐Term Outcome After Substrate‐Based Ablation of LPF VT During SR. Background: Catheter ablation of left posterior fascicular (LPF) ventricular tachycardia (VT) is commonly performed during tachycardia. This study reports on the long‐term outcome of patients undergoing ablation of LPF VT targeting the earliest retrograde activation within the posterior Purkinje fiber network during sinus rhythm (SR).Methods: This study retrospectively analyzed 24 consecutive patients (8 female; mean age 26 ± 11 years) referred for catheter ablation of electrocardiographically documented LPF VT. Programmed stimulation was performed to induce tachycardia, while mapping and ablation was aided by use of a 3D electroanatomical mapping system. Catheter ablation targeted the earliest potential suggestive of retrograde activation within the posterior Purkinje fiber network (retro‐PP) recorded along the posterior mid‐septal left ventricle during SR if LPF VT was noninducible.Results: Overall, 21/24 (87.5%) patients underwent successful catheter ablation in SR targeting the earliest retro‐PP, while 3/24 (12.5%) patients were successfully ablated during tachycardia. In none of the patients, ablation resulted in LPF block. No procedure‐related complications occurred. After a median follow‐up period of 8.9 (4.8–10.9) years, 22/24 (92%) patients were free from recurrent VT.Conclusion: In patients presenting with LPF VT, ablation of the earliest retro‐PP along the posterior mid‐septal LV during SR results in excellent long‐term outcome during a median follow‐up period of almost 9 years. (J Cardiovasc Electrophysiol, Vol. 23, pp. 1179–1184, November 2012)
Prevalence and Predictors of Cable Extrusion and Loss of Electrical Integrity with the Riata Defibrillator Lead
Authors: SHEN SHARON , BHAVE PRASHANT , GIEDRIMAS EVAN , PATEL TARAL , ARORA RISHI , CHICOS ALEXANDRU B. , GOLDBERGER JEFFREY J. , ILKHANOFF LEONARD , KIM MICHAEL H. , LIN ALBERT C. , PASSMAN ROD , LEE RICHARD , KNIGHT BRADLEY P. , KIM SUSAN S. 
Published: May 2012

Prevalence and Predictors of Riata Cable Extrusion. Introduction: Recently, a medical advisory was issued regarding the Riata and Riata ST silicone endocardial defibrillator leads (St. Jude Medical, Sylmar, CA, USA) addressing the issue of conductor cables extruding in an “inside‐out” fashion from the main body of the lead. However, little data exist to guide our management of patients with these leads.Methods and Results: A retrospective analysis was performed of 84 patients with a Riata lead who underwent cine‐fluoroscopy and electrical evaluation as part of a screening program to assess for cable extrusion. All leads screened were dual‐coil except for one single‐coil lead. Of 84 patients, 23 patients (27.4%) had fluoroscopic evidence of cable extrusion. Multivariate analysis showed that the duration of time since lead implant and the presence of multiple right ventricular leads were significantly associated with cable extrusion. All 23 patients had normal electrical parameters on routine device interrogation. Fifteen of these 23 patients (65%) with extruded cables had high‐voltage shocks within 12 months of lead screening; only one patient demonstrated postshock electrical abnormalities.Conclusions: The prevalence of cable extrusion in dual‐coil Riata leads is significantly higher at 27.4% than previously reported. The duration of time since implantation and the presence of multiple right ventricular leads are associated with cable extrusion. High‐energy shocks did not reveal electrical abnormalities in most patients with cable extrusion. (J Cardiovasc Electrophysiol, Vol. 23, pp. 1207–1212, November 2012)
Decomposition‐Coarsening Model of SiOC/HfO2 Ceramic Nanocomposites Upon Isothermal Anneal at 1300°C
Authors: Kleebe Hans‐Joachim , Nonnenmacher Katharina , Ionescu Emanuel , Riedel Ralf 
Published: May 2012

Pronounced variations of the crystallite size of hafnia (HfO2) precipitates in silicon oxycarbide (SiOC)–HfO2 ceramic nanocomposites were studied by TEM upon annealing bulk samples at 1300°C for times ranging from 1 to 200 h. TEM investigations revealed homogeneous nucleation and crystallization of hafnia in the amorphous, Hf‐bearing SiOC matrix upon pyrolysis at 1300°C. Unexpectedly, high‐temperature anneal resulted in a pronounced coarsening of the hafnia crystallites at internal surfaces, due to a decrease of the C content at surface‐near regions. Based on the crystallite size, the diffusion coefficient of Hf was calculated via the Lifshitz‐Slyozov‐Wagner (LSW) theory for Ostwald ripening for both the bulk and internal surface regions. The diffusion coefficient of hafnium, DHf, in the C‐depleted surface areas was 10−18 m2/s, whereas DHf of the SiOC bulk was three orders of magnitude lower with 10−21 m²/s. The present work underlines that the polymer‐derived ceramics are in fact prone to phase separation and local chemical changes upon high‐temperature treatment and are not as stable as commonly considered.
Synthesis and Characterization of Single Crystalline Hafnium Carbide Nanowires
Authors: Yuan Jinshi , Zhang Han , Tang Jie , Shinya Norio , Nakajima Kiyomi , Qin Lu‐Chang 
Published: May 2012

Hafnium carbide (HfC) is the most refractory compound known to mankind. A catalyst‐assisted chemical vapor deposition method has been applied to synthesize contaminant‐layer‐free single crystalline HfC nanowires. The nanowires have diameter of 20–80 nm and length of several tens of microns. High‐resolution transmission electron microscope images and electron diffraction patterns show that most of the nanowires grew in the <100> direction. Morphological and compositional analyses confirmed that the nanowire growth followed the vapor‐liquid‐solid mechanism. Field ion microscopy has also been used to reveal the surface structure of the tip of the nanowires.
Decreasing incidence of placental abruption in Finland during 1980–2005
Authors: TIKKANEN MINNA , RIIHIMÄKI OUTI , GISSLER MIKA , LUUKKAALA TIINA , METSÄRANTA MARJO , ANDERSSON STURE , RITVANEN ANNUKKA , PAAVONEN JORMA , NUUTILA MIKA 
Published: May 2012

AbstractObjective. To study the incidence trends of placental abruption. Design. Register‐based retrospective study. Setting. The Finnish Medical Birth Register and Hospital Discharge Register. Population. A total of 6231 placental abruption cases among 1 576 051 deliveries. Methods. Data on demographic and pregnancy and delivery associated outcomes were collected. Data on overall incidence and maternal age were available 1980–2005. Data on other variables were available 1987–2005. Main outcome measure. Placental abruption Results. The overall incidence of placental abruption was 395/100 000 (0.4%). The incidence decreased 31%, from 487/100 000 in 1980 to 337/100 000 in 2005 (p < 0.001). The incidence was lowest among women aged 20–24 years (305/100 000) and highest among women aged ≥45 years (1309/100 000). During 1987–2005 the incidence was lowest among women with one or two deliveries (353/100 000) and highest in nulliparous women (382/100 000) and in women with three or more deliveries (595/100 000). The incidence was nearly double (577/100 000) among smoking compared with non‐smoking women (341/100 000). The incidence was highest between gestational weeks 26 and 29. Among newborns weighing <1500 g the incidence was higher (5734/100 000) than among those weighing ≥2500 g (251/100 000). The incidence was higher in multiple (903/100 000) than in singleton pregnancies (374/100 000). Conclusion. The incidence of placental abruption decreased during 1980–2005. The incidence was highest among women aged 45 years or more, multiparous and smoking women, in multiple pregnancies and in women with low birthweight newborns.
The prevalence of endometrial hyperplasia and endometrial cancer in women with polycystic ovary syndrome or hyperandrogenism
Authors: HOLM NINA SOFIE LILLEGAARD , GLINTBORG DORTE , ANDERSEN MARIANNE SKOVSAGER , SCHLEDERMANN DORIS , RAVN PERNILLE 
Published: May 2012

Abstract Objective. Polycystic ovary syndrome may be associated with an increased risk of endometrial hyperplasia and endometrial cancer, but substantial evidence for this remains to be established. We investigated the prevalence of endometrial hyperplasia and endometrial cancer in a well characterized group of women with polycystic ovary syndrome and/or clinical/biochemical hyperandrogenism. Design. Retrospective observational trans‐sectional study. Setting. Out‐patient clinic at the Departments of Endocrinology and Gynecology, Odense University Hospital, Denmark. Population. In all, 963 premenopausal women consecutively referred with the diagnoses polycystic ovary syndrome and/or hirsutism during 1997–2008. Methods. All women underwent a standardized evaluation program. In 2011, The Danish Data Bank of Pathology was used to identify women with endometrial histology diagnoses (year range of diagnosis 1982–2011). Main outcome measures. Histology diagnoses, demographic variables. Results. Endometrial hyperplasia was diagnosed in 10 (1.0%) women and endometrial cancer in one (0.1%) woman. The median body mass index of these women was 30.6 kg/m2 compared with 26.8 kg/m2 in the total cohort. There were no differences between the cases and total cohort in terms of individual Rotterdam Criteria. In Denmark, 70 cases of endometrial cancer are diagnosed yearly in women 40–55 years, a prevalence of 0.4% in the corresponding period. Conclusion. The results of the present study do not suggest a higher prevalence of endometrial cancer in women with polycystic ovary syndrome and/or clinical/biochemical hyperandrogenism than in the general population.
Ovarian remnant syndrome: comparison of laparotomy, laparoscopy and robotic surgery
Authors: ZAPARDIEL IGNACIO , ZANAGNOLO VANNA , KHO ROSANNE M. , MAGRINA JAVIER F. , MAGTIBAY PAUL M. 
Published: May 2012

Abstract Objective. To compare laparotomy, laparoscopy and robotic surgery in the management of ovarian remnant syndrome. Design. Retrospective comparative study. Setting. Mayo Clinic Arizona and Mayo Clinic Rochester, USA. Population. Women who underwent surgical treatment for ovarian remnant syndrome. Methods. The clinical records of 223 patients with histologically documented residual cortical ovarian tissue excised at Mayo Clinic by laparotomy, laparoscopy or a robotic approach, from January 1985 through February 2009, were reviewed. Data collected included the patient's age, body mass index, previous medical and surgical history, symptoms, prior management of ovarian remnant syndrome, preoperative imaging study, intraoperative details, postoperative course, complications and follow‐up data. Main outcome measures. Intraoperative and postoperative outcomes. Results. One hundred and eighty‐seven patients (83.9%) were operated by laparotomy, 19 (8.5%) by laparoscopy and 17 (7.6%) by a robotic approach. Estimated blood loss and length of stay were significantly lower in the robotic and laparoscopic groups compared with laparotomy (p < 0.01). After a mean follow‐up of 21.1 ± 32.4 months, the rate of pain improvement was 93.1, 94.4 and 71.4% for the laparotomy, laparoscopy and robotic surgery group, respectively. Conclusions. Robotic and laparoscopic surgery for the treatment of ovarian remnant syndrome offer advantages over laparotomy in terms of reduced blood loss, lower postoperative complications and shorter length of stay.
Does antenatal physical therapy for pregnant women with low back pain or pelvic pain improve functional outcomes? A systematic review
Authors: RICHARDS EMMA , VAN KESSEL GISELA , VIRGARA ROSA , HARRIS PAULA 
Published: May 2012

AbstractObjective. A systematic review was undertaken to update the understanding of the available evidence for antenatal physical therapy interventions for low back or pelvic pain in pregnant women to improve functional outcomes when compared with other treatments or no treatment. Data Sources. Seven electronic databases were systematically searched and supplemented by hand searching through reference lists. Methods of study selection. Two reviewers independently selected trials for inclusion and independently assessed the internal validity of the included trials using the Clinical Appraisal Skills Program tool. Results. Four trials with 566 participants were identified that met the inclusion criteria. The validity of the trials was moderate. Exercise, pelvic support garments and acupuncture were found to improve functional outcomes in pregnant women with low back or pelvic pain. No meta‐analysis was performed because of the heterogeneity of functional outcome measures. Conclusions. While there is some evidence that physical therapy using exercise, acupuncture and pelvic supports may be useful, further research needs to consider other treatment modalities used by physical therapists and establish an appropriate, reliable and valid functional outcome measure to assess low back and pelvic pain in pregnancy.
Angiogenesis and lymphangiogenesis in mucoepidermoid carcinoma of minor salivary glands
Authors: Gleber‐Netto Frederico Omar , Florêncio Taynara Nunes Guedes , de Sousa Silvia Ferreira , Abreu Mauro Henrique Nogueira Guimarães , Mendonça Elismauro Francisco , Aguiar Maria Cássia Ferreira 
Published: May 2012

J Oral Pathol Med (2012) 41: 603–609Background:  Mucoepidermoid carcinoma is the most common malignant tumor of salivary glands. This tumor is characterized by a great variability in clinical behavior, and little is known about the pathological mechanisms involved in its variance. Angiogenesis is an important step in tumor progression and is believed to be an essential event for metastatic dissemination.Methods:  We aimed to investigate angiogenesis and lymphangiogenesis in mucoepidermoid carcinoma measuring the density of neoformed and lymphatic vessels using CD105 and D2‐40 antibodies, respectively, and by immunohistochemical evaluation of VEGF‐A and VEGF‐C proteins. It was also investigated the expression of D2‐40 in neoplastic cells.Results:  We studied 26 cases of mucoepidermoid carcinoma, which showed great angiogenic activity measured by neoformed vessel density. However, a low density of lymphatics was observed. VEGF‐A, VEGF‐C, and D2‐40 were commonly detected in mucoepidermoid carcinoma, but only VEGF‐A expression correlated with neoformed vessel density. Recurrence and nodal metastasis were associated with low VEGF‐A expression and low neoformed vessel density, indicating that impaired angiogenesis could lead to an aggressive phenotype.Conclusions:  Angiogenesis seems important in the modulation of mucoepidermoid carcinoma pathogenesis; however, none of the parameters analyzed could predict tumor behavior.
Transfection of hypoxia‐inducible factor‐1 decoy oligodeoxynucleotides suppresses expression of vascular endothelial growth factor in oral squamous cell carcinoma cells
Authors: Imai Mie , Ishibashi Hiroaki , Nariai Yoshiki , Kanno Takahiro , Sekine Joji , Onimaru Mitsuho , Mori Yoshihide 
Published: May 2012

J Oral Pathol Med (2012)Vasculature development is thought to be an important aspect in the growth and metastasis of solid tumors. Among the many angiogenic factors produced by tumor cells, vascular endothelial growth factor (VEGF) is considered to play a key role in angiogenic processes. VEGF synthesis is modulated by hypoxia‐inducible factor‐1 (HIF‐1) function within the hypoxic microenvironment of growing cancer tissue. To inhibit HIF‐1 activation, oligodeoxynucleotides (ODNs) were synthesized and transferred with either the consensus sequence for HIF‐1 binding or a mutated form of this sequence. If we could transfer a large number of ODNs into the cancer cell nucleus, activated HIF‐1 might bind to the ODNs, resulting in inhibition of hypoxia‐induced VEGF synthesis. We transferred these ODNs into cultured oral squamous cell carcinoma cells (SAS cells) using the hemagglutinating virus of Japan (HVJ)‐liposome method. Hypoxia‐mediated expression of VEGF by cancer cells was suppressed by transfection of HIF‐1 decoy ODNs, but not by mutated HIF‐1 decoy ODNs. HIF‐1 decoy ODN transfection also inhibited VEGF protein synthesis. These results suggest that transfection with HIF‐1 decoy ODNs is effective for regulating tumor growth by reducing VEGF.
Hepatitis B virus reactivation in hepatocellular carcinoma patients undergoing transcatheter arterial chemoembolization therapy
Authors: PENG Jie‐Wen , LIN Gui‐Nan , XIAO Jian‐jun , JIANG Xiao‐Mei 
Published: May 2012

AbstractAim:  The effect of transcatheter arterial chemoembolization (TACE) therapy on hepatitis B virus (HBV) reactivation in hepatocellular carcinoma (HCC) patients with prior resolved hepatitis B is not fully understood.Methods:  From January 2006 to December 2010, 43 hepatitis B surface antigen (HBsAg)‐negative/anti‐hepatitis B core antigen (HBc) positive patients with newly diagnosed unresectable HCC were enrolled in the study. All underwent TACE therapy.Results:  Four patients (9.3%) developed HBV reactivation with mild/moderate hepatitis. The median number of TACE cycles received was 3.5 (range 3–4 cycles). The median time interval between the occurrence of HBV reactivation and the completion of TACE therapy was 3 months (range 1–5 months) and their median HBV DNA level was 1.58 × 104 IU/mL (range, 1.65 × 103–6.42 × 104 IU/mL). After the introduction of lamivudine at the occurrence of HBV reactivation, all had resolution of hepatitis. An exploratory analysis indicated that significant predictors of HBV reactivation included increased serum total bilirubin coexisting with cirrhosis and the total number of cycles of TACE received.Conclusion:  The administration of TACE therapy may increase the risk of HBV reactivation in HBsAg‐negative/anti‐HBc‐positive patients diagnosed with unresectable HCC. Further studies are warranted to explore the optimal management of HBV reactivation in patients with prior resolved hepatitis B.
Efficacy of erlotinib in patients with advanced Non‐small‐cell Lung Cancer (NSCLC): Analysis of the Australian subpopulation of the TRUST study
Authors: BOYER Michael , HORWOOD Keith , PAVLAKIS Nick , DE SOUZA Paul , MILLWARD Michael , STEIN Brian , JOHNSTON Michael , ABELL Fiona , RISCHIN Danny 
Published: May 2012

AbstractAims:  The efficacy of erlotinib (Tarceva, Roche Products, Dee Why, Australia) has been demonstrated in patients with advanced non‐small‐cell lung cancer (NSCLC). Tarceva lung cancer survival treatment (TRUST) is an open‐label, single‐arm, phase IV global trial which investigated erlotinib in advanced NSCLC patients who had failed prior therapy or were unsuitable for chemo/radiotherapy. The aim of this analysis was to report the safety and efficacy of erlotinib in the Australian patient subpopulation.Methods:  Patients with stage IIIB/IV NSCLC progressing after standard systemic chemotherapy or unsuitable to receive chemo/radiotherapy were eligible for the study. The patients were treated with erlotinib at 150 mg/day orally, until disease progression or unacceptable toxicity.Results:  In Australia, 460 patients were recruited. Erlotinib was given as first‐line (16%), second‐line (49%) or third‐line (35%) treatment. In the intent‐to‐treat population (N = 460), the median progression‐free survival was 2.7 months (95% CI 2.3–3.4), 1‐year survival was 35% (95% CI 30–39%) and median overall survival was 6.9 months (95% CI 5.7–8.0). Tumor response rates were available for 363 patients, with a disease control rate of 58%. Of the 460 patients included in the safety analysis, 24% had one or more erlotinib‐related adverse event (AE). Rash was reported in 77% of patients, most commonly grade 1/2 (63%). Treatment‐related serious AE were reported in 7% of patients; most commonly diarrhea (2%). Dose modifications were required in 18% of patients.Conclusions:  Outcomes for Australian patients confirmed the efficacy and tolerability of erlotinib for the treatment of advanced NSCLC in routine clinical practice.
Emergency laparoscopic repair for strangulated groin hernias: A single centre experience
Authors: Leung Alex L.H. , Yang George P.C. , Chan Oliver C.Y. , Lai Eric C.H. , Tang Chung‐Ngai , Li Michael K.W. 
Published: May 2012

AimThe aim of the present study was to evaluate the efficacy of laparoscopic management for strangulated groin hernias.Patients and MethodsFrom January 2007 to December 2009, the perioperative and long‐term results of a consecutive series of patients who underwent laparoscopic repair of strangulated groin hernia were retrospectively analysed. The demographic data of patients, types of hernia, levels of peritoneal contamination, details of surgical techniques, hernia contents, conversion rate, operation time, postoperative complications, follow‐up time and recurrent rate were recorded.ResultsA total of 43 patients with strangulated groin hernia admitted via casualty during the study period were managed by the laparoscopic approach in our unit. We operated on 36 inguinal hernias, 10 femoral hernias and three obturator hernias; five of these were recurrent hernias, and six patients had concurrent groin hernias. We adopted a totally extraperitoneal (TEP) approach for 37 patients and the transabdominal preperitoneal (TAPP) approach for four patients with femoral hernias; two obturator hernias were repaired by board ligaments. None required conversion. One patient had a small perforation of the small bowel during reduction of hernia content, which was repaired primarily; the TEP approach was performed subsequently. None had postoperative infection. One patient had haematoma, and five patients had seroma; all were treated conservatively. The mean operation time was 75 min. The mean postoperative hospital stay was 3.5 days. For those younger than 60 years, the mean postoperative hospital stay was 1.7 days. The mean follow‐up time was 14 months. There were no recurrences.ConclusionFor selected patients, laparoscopic repair for strangulated groin hernias is safe and feasible, with a low rate of infection, complications and recurrence.
Schools, Bullying, and Inequality: Intersecting Factors and Complexities with the Stratification of Youth Victimization at School
Authors: Peguero Anthony A. 
Published: May 2012

AbstractBullying within United States (US) schools is a growing concern among parents, school officials and policymakers. In early 2011, the first‐ever White House Conference on Bullying Prevention was held in hope of addressing bullying within US schools. Although the social, political, and media attention is increasing, it is important to consider the complexities and disparities associated with school bullying. In this article, four of the wide array of influences that increase the vulnerabilities of youth to be a victim of bullying at school are reviewed: (i) race and ethnicity, (ii) being and immigrant, (iii) gender, and; (iv) sexual orientation. Understanding and acknowledging the inequalities associated with school bullying, as well as the policies implemented in response, is instrumental for the US’ efforts towards providing safe, healthy, and democratic learning environments.