bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN JUMLAH PERDARAHAN DENGAN KEJADIAN HIPOTENSI PADA PASIEN SECTIO CAESARIA DENGAN SPINAL ANESTESI DI RSI UNISMA MALANG
Authors: Paryadi Paryadi , Kurniawan Ardhiles Wahyu , Sintara Sindu , Negoro Widigdo Rekso 
Published: April 2024

Pendahuluan: Sectio caesaria dapat menyebabkan perdarahan yang bisa menurunkan volume intravaskuler dan berakhir pada penurunan cardiac output. Jika kondisi ini tidak segera ditangani akan memicu terjadinya hipotensi. Angka kematian ibu meningkat sebanyak 40-80% akibat perdarahan pada persalinan sectio caesaria. Tujuan penelitian ini untuk mengetahui hubungan jumlah perdarahan dengan kejadian hipotensi pada pasien sectio caesaria dengan spinal anestesi di RSI Unisma Malang. Metode: Penelitian analitik observasional menggunakan metode Cross-sectional. Jumlah total sampel 26 pasien, data didapatkan dari observasi langsung dengan dokumentasi sesuai prosedur yang telah mendapatkan informed consent. Pengambilan sampel dilakukan menggunakan teknik purposive sampling. Analisis statitistik univariat dilanjutkan uji statistik Spearman’s rho. Hasil: Ada korelasi yang sangat kuat antara jumlah perdarahan dengan kejadian hipotensi pada pasien sectio caesaria dengan spinal anestesi di RSI Unisma Malang (p= 0.000 < α 0.05; r = 0.902). Kesimpulan: Terdapat korelasi positif yang sangat kuat antara jumlah perdarahan dengan kejadian hipotensi, yang berarti semakin tinggi jumlah perdarahan dapat menurunkan tekanan darah (hipotensi).
Kata kunci: Hipotensi, Jumlah perdarahan, Sectio Caesaria, Spinal anestesi
PENGARUH PENDIDIKAN KESEHATAN DENGAN MEDIA VIDEO TENTANG SPINAL ANESTESI TERHADAP TINGKAT KECEMASAN PASIEN YANG AKAN DILAKUKAN TINDAKAN OPERASI SPINAL ANESTESI
Authors: Hartanto Arvin Wahyu , Priyonggo Reko , Umifa Kaslinda Nur , Zakaria Amin 
Published: April 2024

Pendahuluan: Pembedahan melibatkan prosedur invasif dengan memnggunakan anestesi, hal ini dapat menimbulkan kecemasan dan takut pada pasien dan keluarganya. Anestesi bertujuan untuk menghilangkan rasa nyeri, takut, dan ketidaknyamanan sehingga pasien merasa lebih nyaman selama prosedur medis. Persiapan pra-operasi sangat penting untuk memastikan kondisi fisik dan psikis pasien siap menjalani prosedur anestesi dan pembedahan. Lebih dari 50% pasien pra-operasi mengalami kecemasan di seluruh dunia, dengan 5-25% di antaranya berusia di atas 20 tahun. Di Indonesia, sekitar 11,6% populasi mengalami ansietas. Kecemasan dapat menyebabkan penundaan tindakan operasi, memperpanjang waktu pemulihan, dan meningkatkan risiko komplikasi. Pendidikan kesehatan melalui video tentang spinal anestesi dianggap sebagai metode yang efektif karena dapat dilakukan kapan saja dan di mana saja, serta dapat meningkatkan pengetahuan dan keterampilan pasien. Penelitian ini menganalisa pengaruh edukasi pasien menggunakan video tebtabg spinal anestesi terhadap penurunan tingkat kecemasan. Metode: Desain penelitian pre eksperimental one group pre-post test design, pada populasi pasien yang masuk lewat rawat jalan yang akan dilakukan tindakan operasi dengan spinal anestesi berjumlah 30 responden, penelitian dilaksanakan di ruang tunggu kamar operasi dalam waktu penelitian dua minggu. Variabel bebas: pemberian pendidikan kesehatan dengan media video tentang spinal anestesi. Variabel terikat: tingkat kecemasan. Pengumpulan data menggunakan metode observasi, dilakukan pre dan post pemberian pendidikan kesehatan dengan menggunakan media video tentang spinal anestesi. Instrument menggunakan The Amsterdam Preoperative Anxiety and Information Scale (APAIS) dan dicatat pada lembar observasi. Analisis data bivariate yaitu dengan menggunakan Uji Beda T-Test Independent data yang dilakukan untuk mengetahui perbedaan nilai rata – rata tingkat kecemasan antara pre dan post perlakukan, dan data yang diperoleh diolah menggunakan komputer aplikasi SPSS 22. Hasil: Pengujian hipotesa nilai signifikansi adalah 0.000 yang mana kurang dari 0.05. Kesimpulan: oleh karena itu pengambilan keputusan untuk pengujian ini bahwa: pemberian pendidikan kesehatan dengan media video tentang spinal anestesi berpengaruh terhadap penurunan tingkat kecemasan pasien yang akan dilakukan tindakan operasi dengan spinal anestesi dan pengaruhnya sangat kuat.
Kata kunci: Media Video, Pendidikan Kesehatan, Spinal Anestesi, Tingkat Kecemasan.
Analysis of Digital Green Innovation Based on Schweizer–Sklar Prioritized Aggregation Operators for Interval-Valued Picture Fuzzy Supply Chain Management
Authors: Ali Zeeshan , Rehman Usama 
Published: April 2024

Digital green innovation economics and management for Industry 5.0 was not widely recognized, and the commonly referenced industry paradigm was Industry 4.0. Furthermore, digital green innovation is part ofthe above information referring to the integration of digital technologies with environmentally sustainable practices to develop innovative solutions that evaluate ecological challenges. In this manuscript, we evaluate the Schweizer–Sklar operational laws based on interval-valued picture fuzzy (IVPF) values. Further, we investigate prioritized aggregation operators based on Schweizer–Sklar operational laws for IVPF information, called IVPF Schweizer–Sklar prioritized averaging operator, IVPF Schweizer–Sklar prioritized geometric operator, IVPF Schweizer–Sklar prioritized weighted averaging operator, and IVPF Schweizer–Sklar prioritized weighted geometric operator. Some properties for the above-initiated operators are also derived. Additionally, we analyze the digital green innovation with the help of multi-attribute decision-making technique for initiated operators to show the reliability and supremacy of the proposed theory. Finally, we demonstrate examples for addressing the comparison among the initiated theory and existing ideas to improve the worth of the derived theory.

Received: 26 January 2024 | Revised: 18 March 2024 | Accepted: 28 March 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.

Author Contribution Statement
Zeeshan Ali: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing – original draft, Writing – review & editing, Visualization, Supervision, Project administration, Funding acquisition. Usama Rehman: Validation, Formal analysis, Investigation, Resources, Data curation, Writing – review & editing, Visualization.
Time-Aware Similarity Integration for User-Based Collaborative Filtering
Authors: Lee Soojung 
Published: April 2024

A time-aware collaborative filtering-based recommender system provides item recommendations for the current user by prioritizing recent items preferred by similar neighbors over past preferred items. The similarity measure critically affects the performance of the system, and this study focuses on measuring the similarity between users that changes over time. After dividing the users’ rating time into intervals and computing similarity for each time interval, the final similarity is generated as a weighted sum by assigning lower weights to past similarity values and higher weights to more recent similarity values. Additionally, to ensure continuity of similarity measurement, consecutive time intervals are set to overlap. As a result of experiments applying the proposed method to the existing similarity measures, significant performance improvement was achieved in terms of some of the major performance metrics. In particular, the degree of coverage improvement was the highest, and the performance improvement effect was higher when the overlap size between time intervals was large rather than when it was small.

Received: 23 February 2024 | Revised: 4 April 2024 | Accepted: 15 April 2024

Conflicts of Interest
The author declares that she has no conflicts of interest to this work.

Data Availability Statement
The MovieLens dataset that support the findings of this study are openly available at https://grouplens.org/datasets/movielens/1m/.
THE EFFECT OF INFLATION, EXPORT-IMPORT AND INTEREST RATES ON SALES THROUGH GDP/GDP MODERATION VARIABLES
Authors: Akbar Taufik - 
Published: April 2024

This study aims to determine the effect of inflation, export-import, interest rates on sales in state-owned pharmaceutical holding companies with moderating variables of Gross Domestic Product (GDP). The type of research used is quantitative with primary and secondary data sources related to inflation, export-import, interest rates, GDP and sales. The data used is a combination of time series data for 2018-2022 and cross-section which is then referred to as panel data. The study was also conducted in more depth using a research instrument in the form of a questionnaire with respondents as many as six people who had positions as department heads in the parent company of Pharmaceutical SOEs. Data analysis techniques use multiple linear regression analysis and Moderating Regression Analysis. The results showed that simultaneously the variables of inflation, export-import and interest rates had a positive and significant effect on sales. Meanwhile, the moderation variable, namely GDP, partially affects sales, but cannot moderate the influence of inflation and export-import both in terms of strengthening and weakening the influence of the independent variable on the dependent variable. Other research results show GDP can be a pure moderator of the influence of interest rates on sales. This research has limitations, namely the variables used are macro, therefore for future research it is expected to be able to conduct research using micro variables in the economy.

Keywords: Inflation, Export-Import, Interest Rate, GDP, Sales and Holding Company of SOEs.
RESPUESTA DEL MAÍZ A LA APLICACIÓN DE DIFERENTES DOSIS DE NITRÓGENO EN ROTACIÓN CON KUDZÚ Pueraria phaseoloides, BAJO DOS TIPOS DE LABRANZA.
Authors: Polo Ledezma Edgar Alexis , Urieta Sebastián , Moreno Yaliska 
Published: April 2024

Se realizó un experimento para evaluar la respuesta del maíz a cinco dosis de nitrógeno (0, 50, 100, 150 y 200 kg/ha) en forma de urea, bajo el sistema de siembra en rotación con la leguminosa Kudzú (Pueraria phaseoloides), en dos tipos de labranzas. Se utilizó el diseño experimental de parcelas subdivididas (labranza * dosis de nitrógeno). En la parcela principal se evaluaron las labranzas (conservación y convencional) y en las subparcelas las dosis de nitrógeno. Las parcelas estaban arregladas en bloques completos al azar con tres repeticiones. En las parcelas con labranza de conservación la leguminosa y algunas malezas presentes se cortaron y dejaron sobre la parcela; mientras que en las parcelas con labranza convencional, se cortó toda la parte vegetativa de la planta de kudzú y se incorporó en el suelo, con tres pases de monocultivador. Se encontró respuesta altamente significativa para el rendimiento de maíz, por el rendimiento de maíz, por el efecto residual de kudzu. Los rendimientos de maíz en las parcelas donde se utilizó el kudzu como cobertura fueron de 4.6 ton/ha; mientras que en las parcelas donde se incorporó el kudzu solo hubo 3.6 ton/ha. La respuesta en rendimiento del maíz a la aplicación de nitrógeno también resulto altamente significativa, para los niveles 0, 50, 100, 150 y 200 kg de N/ha respectivamente. El rendimiento promedio de maíz disminuyó cuando se paso del nivel 150 a 200 kg de N/ha.
Downregulation of circ_0119412 expression inhibits malignant progression of breast cancer by targeting the miR-1205/GALNT6 pathway in vivo and in vitro
Authors: Liu Jianhua , Du Qiuli , Yang Yong 
Published: April 2024

IntroductionAberrant circular RNA (circRNA) expression is associated with development of breast cancer. In this study, we aimed to assess the anti-proliferative effect of <i>circ_0119412</i> knockdown on breast cancer cells.Material and methodsTumor and adjacent normal tissues were collected from 35 patients with invasive breast cancer (mean age: 56 years; mean tumor size: 2 cm; 46% patients with TNM I and II stages). The levels of <i>circ_0119412</i>, microRNA (<i>miR</i>)-1205, and N-acetylgalactosaminyltransferase 6 (<i>GALNT6</i>) were determined using reverse transcription-quantitative polymerase chain reaction. Cell proliferation and invasion were assessed using cell counting kit-8 and transwell assays, respectively. Cell apoptosis was assessed using flow cytometry. Moreover, the targeting relationships of <i>miR-1205</i> with <i>circ_0119412</i> and <i>GALNT6</i> were determined using dual-luciferase reporter and RNA immunoprecipitation assays. Furthermore, tumor growth was observed in an animal model in vivo.ResultsWe found that <i>circ_0119412</i> expression levels were upregulated in breast cancer tumor specimens and cell lines. Downregulation of <i>circ _0119412</i> inhibited the invasion and proliferation, while enhancing the apoptosis of breast cancer cells. Furthermore, <i>circ_0119412</i> knockdown suppressed tumor growth in vivo. Notably, <i>miR-1205</i> was identified as a downstream target of <i>circ_0119412</i>. Downregulation of <i>circ_0119412</i> suppressed the aggressive behavior of breast cancer cells by targeting <i>miR-1205</i>. Moreover, <i>GALNT6</i> was the downstream target of <i>miR-1205</i>. Inhibition of <i>miR-1205</i> aggravated the malignant behavior of breast cancer cells by increasing <i>GALNT6</i> expression.ConclusionsOur findings suggest that the downregulation of <i>circ_0119412</i> inhibits breast cancer progression, at least in part, by targeting the <i>miR-1205/GALNT6</i> pathway.
LncRNA NEAT1 contributes to multiple myeloma progression via upregulating ARPC5 by sponging miR-133a
Authors: Wang Fujue , Zeng Piaorong , Lu Zhongwei , Long Xingxing , Luo Cong , Zuo Juan , Cao Yixiong , Wen Feng , Li Junjun , Luo Zeyu 
Published: April 2024

IntroductionLong non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) is confirmed to be involved in regulation of the multiple myeloma (MM) process. However, its underlying molecular mechanism deserves further investigation.Material and methodsQuantitative real-time PCR was used to examine NEAT1, microRNA (miR)-133a and actin-related protein 2/3 complex subunit 5 (ARPC5) expression. Cell proliferation and apoptosis were evaluated by cell counting kit 8 assay, soft-agar colony formation assay and flow cytometry. Dual-luciferase reporter assay was used to confirm the interaction between miR-133a and NEAT1 or ARPC5. The localization of NEAT1 and miR-133a in MM cells was determined by fluorescent in situ hybridization assay. In addition, animal experiments were conducted to explore the effect of NEAT1 knockdown on MM tumor growth in vivo.ResultsNEAT1 had increased expression in MM patients and cells. NEAT1 knockdown could repress MM cell proliferation and enhance apoptosis. NEAT1 could sponge miR-133a, and miR-133a could target ARPC5. MiR-133a was lowly expressed and ARPC5 was highly expressed in MM patients. MiR-133a inhibitor could abolish the suppressive effect of NEAT1 knockdown on MM cell growth, and these effects also could be reversed by ARPC5 silencing.ConclusionsAnimal experiments showed that NEAT1 downregulation reduced MM tumor growth by regulating miR-133a/ARPC5 axis. NEAT1 facilitated MM progression through the regulation of miR-133a/ARPC5, which provided new evidence that NEAT1 was a potential therapeutic target for MM.
Patterns and prevalence of psychiatric morbidity
among individuals with rheumatoid arthritis
Authors: Khan Ajaz Kariem , Nabi Junaid , Parrey Ashaq Hussain , Rath Prasan Deep , Lone Sanan 
Published: April 2024

ObjectivesRheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints, causing inflammation, pain, and potential joint damage. Patients with RA are at high risk of developing psychiatric morbidity; it is important to recognize these psychiatric manifestations. The relationship between psychiatric symptoms and RA is complex and can involve various factors, including the impact of chronic pain, inflammation, medications, and the overall burden of managing a chronic illness.
Aim of the study was to systematically investigate and analyze the patterns and prevalence of psychiatric morbidity among individuals diagnosed with RA, with the aim of identifying common mental health conditions, understanding the interplay between RA and psychiatric disorders, and providing valuable insights for improved holistic patient care.Material and methodsThis was a prospective, observational cross-sectional study conducted over a period of three years in patients with RA. Psychiatric morbidity was assessed using International Classification of Diseases-10 criteria and Mini-Plus by dedicated psychiatrists. The diagnosis of RA was confirmed using the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) diagnostic criteria for RA and the disease activity was calculated by Disease Activity Score with 28-joint count (DAS28) using the calculator from the RheumaHelper application. The data were analyzed using SPSS, version 23.0.ResultsA total of 1,000 patients with RA were included in this study. Nearly two-thirds of the patients were female (64.8%). The majority of patients belonged to the age group of 41 to 54 years. Total 47.5% of the patients were unemployed, 27.0% were salaried, 19.0% were businessman, while 6.5% of the patients were students. More than half of the patients (53.2%) had moderate disease activity. Major depressive disorder was the most commonly observed comorbidity (41.0%), followed by somatoform disorder (28.5%), and generalized anxiety disorder was found in 13.5%. No psychiatric manifestations were found in 17% of studied individuals.ConclusionsPsychiatric morbidity is associated with RA and there is a need for psychiatric services to be made available to these patients.
ATTITUDES OF TEACHERS TOWARDS LEARNERS WHO ARE MENTALLY CHALLENGED IN NYAMAIYA DIVISION NYAMIRA COUNTY, KENYA; A CROSS SECTIONAL STUDY.
Authors: Nyareso Isoe Joyce , Chelilim David 
Published: April 2024

Background:
This study aims to find out the attitudes of teachers toward learners who are mentally challenged in Nyamaiya division of Nyamira County, Kenya.
Methodology:
This study adopted a cross-sectional survey research design. The study was conducted in Nyamira Township, Nyamira County Kenya. The target population needed all countries in the continent as they served less than 1% of the population with special needs consisting of head teachers and teachers of public primary schools. The total number of teachers was 260. The study adopted proportionate random sampling to select (30%) of public primary schools from the township. The data was generated using questionnaires and observation schedules.
Results:
The gender distribution of the respondents shows that 48 (61.5%) are males, while 30 (38.5%) are females. data reveals that teachers in Nyamaiya Division generally have mixed attitudes towards learners who are mentally challenged. Only 12.8% strongly agree, 19.2% agree, 2.6% are neutral, 51.3% disagree, and 14.1% strongly disagree. The majority of teachers either have negative attitudes or are unsure about their stance. There was a pessimistic view among teachers regarding the academic potential of mentally challenged learners. Only 7.7% strongly agree, 7.7% agree, while a significant 33.3% strongly disagree.
Conclusion:
The identified gaps in attitudes underscore the urgency of a multifaceted approach involving targeted interventions, resource allocation, and collaborative efforts among stakeholders. The study emphasizes the need for strategic investments in training, infrastructure, and awareness programs to create an inclusive educational environment conducive to the holistic development of all learners.
Recommendation:
Awareness Campaigns: Launch awareness campaigns targeting both teachers and regular students to foster a positive and inclusive mindset, reducing negative attitudes towards mentally challenged learners.
Uso eficiente del agua en las empresas agrícolas familiares en el Noroeste de México
Authors: Vega-López Laura Leticia , Sagarnaga-Villegas Leticia Myriam , Zepeda-Zepeda José Adolfo , Salas-González José María 
Published: April 2024

Actualmente existe agotamiento de recursos naturales debido a los excesivos hábitos de consumo y patrones de producción en el mundo entero; por tal motivo, es necesaria la concientización del uso eficiente del agua en los diferentes ámbitos. En México, el 76 % del agua se utiliza en la agricultura; 14 % en el abastecimiento público; 5 % en las termoeléctricas y 5 % en la industria. La presente investigación se enfocó en “Empresas Familiares Agrícolas”, ubicadas en Santiago Ixcuintla, Nayarit, México; donde 64 % de la superficie utiliza el riego en cultivos como: frijol, tabaco, caña y hortalizas; el objetivo es identificar los factores que influyen para que estas empresas utilicen eficientemente el agua, así como, la problemática y las expectativas de los empresarios en cuanto a las áreas de desarrollo y mejora de su empresa.
En los resultados se obtuvieron 25 mil observaciones derivadas de 91 encuestas a empresarios agrícolas, se observó que en las actividades productivas las empresas no utilizan eficientemente el agua, ya que se considera que este recurso es abundante. Asimismo, los empresarios están considerando regresar al riego por gravedad, dado que las nuevas tecnologías de riego generan mayores costos de producción; sin embargo, la edad, el nivel de escolaridad y la generación a la que pertenecen los integrantes de las empresas, influyen positivamente en el uso eficiente del agua, pues una mayor educación permite a los productores tener mayor conciencia sobre los problemas medioambientales en general. Las ayudas públicas facilitan la incorporación de nuevas tecnologías y las expectativas que tienen los productores sobre su empresa en los próximos años es positiva.
Navigational Practices and the Use of the Leeboard on Shallow Draft Riverine and Coastal Craft in the Yangzi and Rhine Estuaries
Authors: Blussé Leonard 
Published: April 2024

Both in the shallow Yangtze and Rhine deltas, flat-bottomed sailing craft made use of leeboards to prevent the drift of the ship when reaching or sailing close-hauled. Without a doubt, the leeboard was invented earlier in China, but contrary to what isoften suggested, the Dutch leeboard was not adopted from the Chinese example. Its invention should be considered an independent act, a case of convergence. The leeboard was introduced in the Low Countries simultaneously with the adoptionof the fore-and-aft ‘jib and spritsail’ rig and the transformation from narrow to broader ship hulls during the late Middle Ages. Over time the Dutch leeboard was further refined in form: deep and narrow leeboards for seagoing fishing vessels and round and shallow leeboards for the sailing barges and pleasure craft on lakes, canals, and rivers.