bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Legal Nature of International Organizations
Authors: Reuterswärd Reinhold 
Published: July 2010

AbstractAmong contemporary writers on international law it is a widely held view that international organizations are new kind of subjects of international law besides the States, i.e., have an international legal personality distinct from that of their member States. Many writers, indeed, treat this as something almost self-evident and beyond dispute. Actually, however, the international legal personality of international organizations remains a theoretical thesis rather than a scientific fact. Although this thesis seems to be supported by most writers, there are considerable differences of opinion among theorists as regards both the basis of that international personality and its meaning. Furthermore, some important aspects of the matter have been given little attention by most writers. It would seem, therefore, that the problem is far from solved. Some writers differ from the majority and deny that international organizations have international legal personality. They have, I submit, convincingly shown that there are strong reasons to question the validity of the generally accepted doctrine.1 The purpose of the present paper is to set forth some of the facts which support the view of this minority and which deserve more attention than has so far been given to them.
TERRITORIAL RIGHTS IN GREENLAND legal basis - view points and considerations
Authors: Brosted Jens 
Published: July 2010

AbstractLarge scale mineral and petroleum extraction - in fact or in terms of industry projects and government hopeful expectations - has in recent years been one of the main sources of conflict between indigenous peoples and the larger society encompassing them. This is particularly true of Greenland - not because of the numbers or magnitude of projects - but because there is no individual ownership to land in Greenland, in the traditional western sense and some of the traditional sources of conflict have therefore been absent. For a discussion of aboriginal territorial rights in Greenland, it might therefore be appropriate to take your point of departure in the conflicts which may arise between mineral extraction and the traditional Greenlandic land use. I shall therefore shortly review legal data, which may contribute to the solution of such conflicts. By the same process I'll contribute to the understanding of the legal entity, which is endowed with the territorial rights in Greenland, or - popularly speaking: who owns Greenland. While it is generally recognized that the ownership of Greenland is vested in the public or in the society, is has been disputed which society or what public possess the legal claim to that entitlement. The Home Rule Commission For Greenland contributed no solution to this problem, and the "Home Rule Act" simply laid down, that "the permanent resident population in Greenland have basic rights to the natural resources of Greenland".2 The mining acts for Greenland - both the old one from 1965 (rev. 69) and the one adapted to home rule from 1978 - prescribes that mineral concessions shall respect existing (use) rights (§ 3 resp. 8).3 This suggests two issues: 1.: what are the contents of the protected existing rights and as a sub-issue: who are entitled. This first problem is my main subject in the following, while I shall only touch upon the 2. issue: namely, that the authorities in granting concessions have neglected their duty to examine and safeguard prior existing Greenlandic land use rights. This is still current practice and represent a major reason for the fact that the main issue has yet to be solved. I shall subsequently contribute to the elucidation of existing Greenlandic land use rights by discussing: 1) localized rights, 2) the more general Greenlandic territorial rights and finally 3) the issue of the protection of these Greenlandic rights according to the Danish constitution (§ 73).
Preparing Mare liberum for the Press: Hugo Grotius' Rewriting of Chapter 12 of De iure praedae in November-December 1608
Authors: van Ittersum Martine Julia 
Published: July 2010

AbstractThis article reconstructs the printing history of Hugo Grotius's Mare liberum (The Free Sea, 1609). It examines the political circumstances which prompted the pamphlet's publication, but then seemed to conspire against it, and relates these to Grotius's revision of chapter 12 of Ms. BPL 917 in Leiden University Library, the one surviving copy of De iure praedae (The Commentary on the Law of Prize and Booty, 1604-1608). While preparing chapter 12 for the press, he made a serious effort to tone down its bellicose rhetoric, erasing, for example, all references to the Spanish claims to the Americas. His aim was to placate the French envoy Pierre Jeannin and his own political patron Johan van Oldenbarnevelt, the driving forces behind the negotiations for the Twelve Years' Truce (1609-1621). In the context of these negotiations, Grotius was at pains to downplay his radical rights theories. The subjective right of punishment only received a mention in the conclusion of Mare liberum, for example. Yet a discarded outline for the pamphlet's preface shows that the argument of De iure praedae remained uppermost in his mind, witness the outline's denunciation of the 'poisonings, perfidy and crimes of the Portuguese'. Both De iure praedae and Mare liberum had been commissioned by the Dutch East India Company (VOC) for the express purpose of influencing political developments in its favour. Yet neither treatise had the impact originally intended by Grotius and the VOC directors. Ironically, these occasional writings became classics of international law instead.
Hugo Grotius's Political and Scholarly Activities in the Light of his Correspondence
Authors: Nellen Henk 
Published: July 2010

AbstractThe 7725 letters of Hugo Grotius's correspondence of the years 1594 to 1645 reflect the highlights and drawbacks of an eventful career. Some important gradual developments and abiding features in the letters will be pointed out. In this way Grotius's political and scholarly activities can be analysed from the perspective of the correspondence.
Using the Work. Remarks on the Text of De iure praedae
Authors: Waszink Jan 
Published: July 2010

AbstractThis paper aims at showing that all scholars writing on De iure praedae should refer to the extant manuscript of the work, or to the new electronic edition when it becomes available, to check the passages they use in their arguments. The printed text as edited by Hamaker, though generally reliable as a nineteenth-century edition, must now be considered outdated because of its suppression of all previous stages of the text, as well as its replacement of the original punctuation with a new one, which more than once does affect the meaning of the text. Moreover, Hamaker's edition gives no authentic image of the sources of Grotius's thought. Secondly, signalling a need for more detailed textual research on IPC, the present paper calls attention to Grotius's extensive changes in chapter 10, and to the contribution which philological approaches might make to answering questions such as that regarding IPC's intended audience.
The VOC, Corporate Sovereignty and the Republican Sub-Text of De iure praedae
Authors: Wilson Eric 
Published: July 2010

AbstractThis essay discusses some of the ways in which De iure praedae may be understood to constitute a republican text. It is my argument that the 'Commentary on the Law of Prize and Booty' should be firmly located within the over-arching republican discourse of the juvenilia, although the text's republican content is not immediately apparent. On close examination, a republican sub-text is detectible through the author's treatment of the discursive object of the text, the Dutch East India Company (the VOC), a corporate body. By attempting to legitimate the VOC's natural right to wage just war, Grotius invests a private entity with a public mark of sovereignty. This investiture of a non-state actor with public international legal personality forces a careful reappraisal of two central characteristics of seventeenth-century republican thought: (i) the divisibility of sovereignty, and (ii) the fluid demarcation between the 'public' and the 'private' spheres. I conclude that the VOC may be accurately denoted a 'corporate sovereign', an entity whose legal personality is derived from the corporatist principles that underlined early republican and federalist theory.
Outlines of Hugo Grotius' Poetry
Authors: Eyffinger Arthur 
Published: July 2010

AbstractIn recent decades, interest in Neo-Latin studies shows a distinct upward tendency. Still, the poetry of Dutch humanists constitutes a literature which is difficult to access. However, much work has been done in the past years to open up the poetry of Hugo Grotius. Within a few years the first phase of the edition in the series De Dichtwerken van Hugo Grotius will have been completed with the publication of the juvenilia, the poetry written between 1591 and 1608. Consequently, a well-rounded whole of Grotius' poetry will have become accessible for research and systematic reference. In the meantime, as no in-depth study of Grotius' poetry as preserved in manuscript form and printed edition has ever been undertaken before, a first attempt of closer research and a systematic inventory of the material provided a mass of new data. This led to the repudiation of quite a few traditional conceptions concerning the nature and merits of Grotius' poetical efforts and the correlation of the respective editions of poems. Some major results of this research are presented here in general outline. They are all enlarged on in full detail in my Grotius Poeta (The Hague 1981) and Inventory of the Poetry of Hugo Grotius (Assen 1982). Reference is made to both of these works throughout this article, which has no claims for itself but to offer an overall picture by means of an introductory essay. Therefore footnotes are omitted here altogether.
MJO Signals in Latent Heating: Results from TRMM Retrievals
Authors: Zhang Chidong , Ling Jian , Hagos Samson , Tao Wei-Kuo , Lang Steve , Takayabu Yukari N. , Shige Shoichi , Katsumata Masaki , Olson William S. , L’Ecuyer Tristan 
Published: July 2010

Abstract
Four Tropical Rainfall Measuring Mission (TRMM) datasets of latent heating were diagnosed for signals in the Madden–Julian oscillation (MJO). In all four datasets, vertical structures of latent heating are dominated by two components—one deep with its peak above the melting level and one shallow with its peak below. Profiles of the two components are nearly ubiquitous in longitude, allowing a separation of the vertical and zonal/temporal variations when the latitudinal dependence is not considered. All four datasets exhibit robust MJO spectral signals in the deep component as eastward propagating spectral peaks centered at a period of 50 days and zonal wavenumber 1, well distinguished from lower- and higher-frequency power and much stronger than the corresponding westward power. The shallow component shows similar but slightly less robust MJO spectral peaks. MJO signals were further extracted from a combination of bandpass (30–90 day) filtered deep and shallow components. Largest amplitudes of both deep and shallow components of the MJO are confined to the Indian and western Pacific Oceans. There is a local minimum in the deep components over the Maritime Continent. The shallow components of the MJO differ substantially among the four TRMM datasets in their detailed zonal distributions in the Eastern Hemisphere. In composites of the heating evolution through the life cycle of the MJO, the shallow components lead the deep ones in some datasets and at certain longitudes. In many respects, the four TRMM datasets agree well in their deep components, but not in their shallow components and in the phase relations between the deep and shallow components. These results indicate that caution must be exercised in applications of these latent heating data.
Efficient Local Error Parameterizations for Square Root or Ensemble Kalman Filters: Application to a Basin-Scale Ocean Turbulent Flow
Authors: Brankart Jean-Michel , Cosme Emmanuel , Testut Charles-Emmanuel , Brasseur Pierre , Verron Jacques 
Published: July 2010

Abstract
In large-sized atmospheric or oceanic applications of square root or ensemble Kalman filters, it is often necessary to introduce the prior assumption that long-range correlations are negligible and force them to zero using a local parameterization, supplementing the ensemble or reduced-rank representation of the covariance. One classic algorithm to perform this operation consists of taking the Schur product of the ensemble covariance matrix by a local support correlation matrix. However, with this parameterization, the square root of the forecast error covariance matrix is no more directly available, so that any observational update algorithm requiring this square root must include an additional step to compute local square roots from the Schur product. This computation generates an additional numerical cost or produces high-rank square roots, which may deprive the observational update from its original efficiency. In this paper, it is shown how efficient local square root parameterizations can be obtained, for use with a specific square root formulation (i.e., eigenbasis algorithm) of the observational update. Comparisons with the classic algorithm are provided, mainly in terms of consistency, accuracy, and computational complexity. As an application, the resulting parameterization is used to estimate maps of dynamic topography characterizing a basin-scale ocean turbulent flow. Even with this moderate-sized system (a 2200-km-wide square basin with 100-km-wide mesoscale eddies), it is observed that more than 1000 ensemble members are necessary to faithfully represent the global correlation patterns, and that a local parameterization is needed to produce correct covariances with moderate-sized ensembles. Comparisons with the exact solution show that the use of local square roots is able to improve the accuracy of the updated ensemble mean and the consistency of the updated ensemble variance. With the eigenbasis algorithm, optimal adaptive estimates of scaling factors for the forecast and observation error covariance matrix can also be obtained locally at negligible additional numerical cost. Finally, a comparison of the overall computational cost illustrates the decisive advantage that efficient local square root parameterizations may have to deal simultaneously with a larger number of observations and avoid data thinning as much as possible.
Investigation on residual-related error and the effect of solution properties using protective devices for the reconstitution of cytotoxic agents in actual situations
Authors: Hama Koji , Kitada Noriaki , Fukushima Koichi , Hashida Tohru , Kataoka Kazusaburo 
Published: July 2010

Purpose. Three products can be used in Japan for the reconstitution of cytotoxic agents: PhaSeal, Chemo CLAVE and Chemo Mini Spike (CMS). The low preparation volume may be affected by residual-related volume in their devices. In this study, the residual-related error in their devices was examined and compared. Method. The blank of each component of these devices was weighed using a precision electric balance. After ejecting distilled water (DW) for injection, each was weighed again with the balance. In addition, for etoposide in the cases of PhaSeal and Chemo CLAVE, the components of the devices were similarly weighed. Result. The weight gains of each device after ejecting DW were as follows: CMS-V (440 mg) greater than the combined components of Chemo CLAVE (128—171 mg)/CMS-MT (123 mg) greater than the combined components of PhaSeal (13—56 mg). For etoposide, the weight gains of PhaSeal (208 mg) and Chemo CLAVE (223 mg) showed no significant difference. The priming volume of each device was calculated from the specific gravity of water. The residual-related volume was ‘CMS-V > Chemo CLAVE, CMS-MT > PhaSeal’, although this was very slight in actual situations. Conclusion. The residual-related volume was marked in its low preparation volume. In water-soluble drugs, the residual volume of PhaSeal was lowest of the devices in this study, but in viscous drugs, such as etoposide, the residual volume of PhaSeal was almost identical to Chemo CLAVE; that is, the residual volume of these devices was affected by the solution property. The residual-related volume in the devices will lead to errors; therefore, residual-related errors need to be considered in the use of these devices.
Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition
Authors: Leong Sai Mun , Tan Ban Xiong , Bte Ahmad Baidah , Yan Tie , Chee Lai Yuen , Ang Swee Tin , Tay Kian Ghee , Koh Liang Piu , Yeoh Allen Eng Juh , Koay Evelyn Siew-Chuan , Mok Yu-Keung , Lim Tit Meng 
Published: July 2010

Abstract
In up to one-third of patients with acute myeloid leukemia, a C-terminal frame-shift mutation results in abnormal and abundant cytoplasmic accumulation of the usually nucleoli-bound protein nucleophosmin (NPM), and this is thought to function in cancer pathogenesis. Here, we demonstrate a gain-of-function role for cytoplasmic NPM in the inhibition of caspase signaling. The NPM mutant specifically inhibits the activities of the cell-death proteases, caspase-6 and -8, through direct interaction with their cleaved, active forms, but not the immature procaspases. The cytoplasmic NPM mutant not only affords protection from death ligand-induced cell death but also suppresses caspase-6/-8–mediated myeloid differentiation. Our data hence provide a potential explanation for the myeloid-specific involvement of cytoplasmic NPM in the leukemogenesis of a large subset of acute myeloid leukemia.
Adult hematopoietic stem cells require NKAP for maintenance and survival
Authors: Pajerowski Anthony G. , Shapiro Michael J. , Gwin Kimberly , Sundsbak Rhianna , Nelson-Holte Molly , Medina Kay , Shapiro Virginia Smith 
Published: July 2010

Abstract
Steady-state hematopoiesis is sustained through differentiation balanced with proliferation and self-renewal of hematopoietic stem cells (HSCs). Disruption of this balance can lead to hematopoietic failure, as hematopoietic differentiation without self-renewal leads to loss of the HSC pool. We find that conditional knockout mice that delete the transcriptional repressor NKAP in HSCs and all hematopoietic lineages during embryonic development exhibit perinatal lethality and abrogation of hematopoiesis as demonstrated by multilineage defects in lymphocyte, granulocyte, erythrocyte and megakaryocyte development. Inducible deletion of NKAP in adult mice leads to lethality within 2 weeks, at which point hematopoiesis in the bone marrow has halted and HSCs have disappeared. This hematopoietic failure and lethality is cell intrinsic, as radiation chimeras reconstituted with inducible Mx1-cre NKAP conditional knockout bone marrow also succumb with a similar time course. Even in the context of a completely normal bone marrow environment using mixed radiation chimeras, NKAP deletion results in HSC failure. NKAP deletion leads to decreased proliferation and increased apoptosis of HSCs, which is likely due to increased expression of the cyclin-dependent kinase inhibitors p21Cip1/Waf1 and p19Ink4d. These data establish NKAP as one of a very small number of transcriptional regulators that is absolutely required for adult HSC maintenance and survival.
Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A
Authors: Shi Qizhen , Fahs Scot A. , Kuether Erin L. , Cooley Brian C. , Weiler Hartmut , Montgomery Robert R. 
Published: July 2010

Abstract
The natural cell type(s) that synthesize and release factor VIII (FVIII) into the circulation are still not known with certainty. In vitro studies indicate that artificial expression of FVIII in endothelial cells produces an intracellular pool of FVIII that can be mobilized together with its carrier protein, von Willebrand factor (VWF), by agonists. Here, we show that expression of human B-domain deleted FVIII (hFVIII) in the vascular endothelium of otherwise FVIII-deficient mice results in costorage of FVIII and VWF in endothelial Weibel-Palade bodies and restores normal levels and activity of FVIII in plasma. Stored FVIII was mobilized into the circulation by subcutaneous administration of epinephrine. Human FVIII activity in plasma was strictly dependent on the presence of VWF. Endothelial-specific expression of hFVIII rescued the bleeding diathesis of hemophilic mice lacking endogenous FVIII. This hemostatic function of endothelial cell–derived hFVIII was suppressed in the presence of anti-FVIII inhibitory antibodies. These results suggest that targeting FVIII expression to endothelial cells may establish a releasable pool of FVIII and normalize plasma FVIII level and activity in hemophilia A, but does not prevent the inhibitory effect of anti-FVIII antibodies on the hemostatic function of transgene-derived hFVIII as is seen with platelet-derived FVIII expression.
Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic-susceptible and -resistant bacteria
Authors: Stables Melanie J. , Newson Justine , Ayoub Samir S. , Brown Jeremy , Hyams Catherine J. , Gilroy Derek W. 
Published: July 2010

AbstractInhibition of cyclooxygenase (COX)–derived prostaglandins (PGs) by nonsteroidal anti-inflammatory drugs (NSAIDs) mediates leukocyte killing of bacteria. However, the relative contribution of COX1 versus COX2 to this process, as well as the mechanisms controlling it in mouse and humans, are unknown. Indeed, the potential of NSAIDs to facilitate leukocyte killing of drug-resistant bacteria warrants investigation. Therefore, we carried out a series of experiments in mice and humans, finding that COX1 is the predominant isoform active in PG synthesis during infection and that its prophylactic or therapeutic inhibition primes leukocytes to kill bacteria by increasing phagocytic uptake and reactive oxygen intermediate-mediated killing in a cyclic adenosine monophosphate (cAMP)-dependent manner. Moreover, NSAIDs enhance bacterial killing in humans, exerting an additive effect when used in combination with antibiotics. Finally, NSAIDs, through the inhibition of COX prime the innate immune system to mediate bacterial clearance of penicillin-resistant Streptococcus pneumoniae serotype 19A, a well-recognized vaccine escape serotype of particular concern given its increasing prevalence and multi-antibiotic resistance. Therefore, these data underline the importance of lipid mediators in host responses to in-fection and the potential of inhibitors of PG signaling pathways as adjunc-tive therapies, particularly in the con-text of antibiotic resistance.