bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of microbiota in gastric cancer: A comprehensive review
Authors: Lei Changzhen , Xu Yitian , Zhang Shaopeng , Huang Chen , Qin Jing 
Published: April 2024

AbstractBackgroundGastric cancer (GC) continues to pose a significant global threat in terms of cancer‐related fatalities. Despite notable advancements in medical research and therapies, further investigation is warranted to elucidate its underlying etiology and risk factors. Recent times have witnessed an escalated emphasis on comprehending the role of the microbiota in cancer development.MethodsThis review briefly delves into recent developments in microbiome‐related research pertaining to gastric cancer.ResultsAccording to studies, the microbiota can influence GC growth by inciting inflammation, disrupting immunological processes, and generating harmful microbial metabolites. Furthermore, there is ongoing research into how the microbiome can impact a patient's response to chemotherapy and immunotherapy.ConclusionThe utilization of the microbiome for detecting, preventing, and managing stomach cancer remains an active area of exploration.
A review of the topical management of acne and its associated sequelae in the Asia‐Pacific region with a spotlight on trifarotene
Authors: See Jo‐Ann , Chavda Rajeev , Kon Khen M. , Goodman Greg J. , Oblepias Marie S. , Nadela Rosalina E. , Oon Hazel H. , Aurangabadkar Sanjeev , Suh Dae H. , Chan Henry H. L. , Lahiri Koushik 
Published: April 2024

AbstractAcne, a highly prevalent skin disease, can be particularly bothersome for patients of Asian background because of its impact on self‐confidence and social interactions. In addition to active acne lesions, some patients may develop sequelae such as scarring, macular/postinflammatory hyperpigmentation, or erythema. The tendency of Asian skin to develop sequelae because of its increased susceptibility to irritation, cultural preferences for lighter skin phototypes, and differences in skincare regimens may all contribute to the increased burden of acne. Moreover, many Asia‐Pacific countries do not have their own guidelines for acne management, and those that do often have no schedule in place for regular updates. In this article, we provide a critical review of the published guidance for the management of acne and its sequelae in the Asia‐Pacific region, identifying gaps in current recommendations that could be addressed to enhance standards of acne care in Asia‐Pacific countries. Along with highlighting the importance of a comprehensive skincare regimen to increase treatment efficacy and adherence, we discuss topical retinoids and retinoid combination options in the acne armamentarium that may be beneficial for sequelae prevention and management, such as adapalene 0.3% ± benzoyl peroxide 2.5%, tretinoin 0.05%, tazarotene 0.1%, and trifarotene 0.005%. In particular, trifarotene 0.005% has been observed to significantly reduce acne scar counts in a Phase 4 study. The recent data highlight the need to establish up‐to‐date guidance for acne and acne sequelae management in Asia‐Pacific countries to provide optimal care to Asian patients.
Association of Herpes simplex infection with significantly increased risk of head and neck cancer: real‐world evidence of about 500,000 patients
Authors: von Stebut Jennifer , Heiland Max , Preissner Robert , Rendenbach Carsten , Preissner Saskia 
Published: April 2024

AbstractBackgroundThe role of viral agents in the development of head and neck cancers has remained controversial. While markers of viral origin have been isolated from oral cancer tissues, a causative relationship has yet to be shown. The aim of this study was to evaluate the relationship between head and neck cancers and Herpes simplex virus, one of the most common viral infections of the oral orifice.MethodsHere, we conducted a retrospective analysis of two age‐ and gender‐matched cohorts extracted from the real‐world database TriNetX on March 10th, 2023, each consisting of 249,272 patients with and without Herpes simplex infections (ICD‐10: B00). The diagnoses C00‐C14 were analyzed, and risk analysis and Kaplan‐Meier survival statics were computed.ResultsThe strongest association was found for lip cancer (ICD‐10: C00) with a hazard ratio [HR (CI 95% low‐high)] of 3.08 (1.77–5.35). A significant association with HR of 1.17 (1.02–1.34) was found for the entire group of head and neck cancers. Confounders like smoking and alcohol dependence were considered using propensity score matching.ConclusionThe surprisingly strong correlation with lip, oral cavity, and pharynx neoplasms sheds new light on supposedly harmless herpes simplex infections, suggesting them as a possible new factor for risk stratification.
Defending the Doctrine of the Mean Against Counterexamples: A General Strategy
Authors: Colgrove Nicholas 
Published: April 2024

AbstractAristotle's doctrine of the mean states that each moral virtue stands opposed to two types of vice: one of excess and one of deficiency, respectively. Critics claim that some virtues – like honesty, fair‐mindedness, and patience – are counterexamples to Aristotle's doctrine. Here, I develop a generalizable strategy to defend the doctrine of the mean against such counterexamples. I argue that not only is the doctrine of the mean defensible, but taking it seriously also allows us to gain substantial insight into particular virtues. Failure to take the doctrine seriously, moreover, exposes us to the risk of mistaking certain vices for virtues.
Fiscal institutions and racial equity: Determining the price of water
Authors: Albrecht Kate , Carroll Deborah A. , Kass Amanda , Michnick Jason , Wetmore Brooke 
Published: April 2024

AbstractMunicipal water utilities across the United States establish their own rate structures to cover operations, maintenance, depreciation, and outstanding debt repayment. Yet, little is known about how rates are determined to ensure equity and/or affordability. To identify sources of variation in residential drinking water rates, we examine municipalities in northeastern Illinois, 2015–2019. Controlling for water utility characteristics, billing structures, financial management, service quality, and demographic/socioeconomic factors, we find no statistically significant correlations between water rates and median household income or race when nonrevenue water from leaking infrastructure is considered, revealing relative racial equity in water pricing within these communities. A larger water distribution network, more water included in the base charge, and a greater number of months in the billing cycle are all associated with lower rates. Purchasing water through an individual or cooperative agreement, a greater proportion of nonrevenue water from leaking infrastructure, a higher minimum monthly base charge, and more revenue debt outstanding (while controlling for nonrevenue water) are all associated with higher rates. We also find a positive correlation between municipal sewer rates and drinking water rates that supports findings from prior research. Overall, our research aids in the development of public policy that ensures all households have access to affordable and safe drinking water to promote water equity and public health.
Study of optimal subalgebras, invariant solutions, and conservation laws for a Verhulst biological population model
Authors: Sharma Aniruddha Kumar , Arora Rajan 
Published: April 2024

AbstractIn this research, the (2+1)‐dimensional normal biological population model, incorporating the Verhulst law for population growth, is employed to explore species population dynamics. Employing Lie symmetry analysis, we address a nonlinear degenerate parabolic partial differential equation, yielding much‐improved results. This analysis includes computing one‐dimensional optimal subalgebras, reduced ordinary differential equations, and obtaining invariant solutions with a visual depiction of the physical behavior of the Verhulst biological population model through symmetry group transformations. Additionally, the multiplier method leads to novel conservation laws and potential systems not locally connected to the governing partial differential equation (PDE). These findings have significant implications for understanding and controlling biological populations, offering insights for applications in ecology and the environment.
Oscillatory and regularized shock waves for a modified Serre–Green–Naghdi system
Authors: Bolbot Daria , Mitsotakis Dimitrios , Tzavaras Athanasios E. 
Published: April 2024

AbstractThe Serre–Green–Naghdi equations of water wave theory have been widely employed to study undular bores. In this study, we introduce a modified Serre–Green–Naghdi system incorporating the effect of an artificial term that results in dispersive and dissipative dynamics. We show that the modified system effectively approximates the classical Serre–Green–Naghdi equations over sufficiently extended time intervals and admits dispersive–diffusive shock waves as traveling wave solutions. The traveling waves converge to the entropic shock wave solution of the shallow water equations when the dispersion and diffusion approach zero in a moderate dispersion regime. These findings contribute to an understanding of the formation of dispersive shock waves in the classical Serre–Green–Naghdi equations and the effects of diffusion in the generation and propagation of undular bores.
Mixed‐norm estimates via the helicoidal method
Authors: Benea Cristina , Muscalu Camil 
Published: April 2024

AbstractWe prove multiple vector‐valued and mixed‐norm estimates for multilinear operators in , more precisely for multilinear operators associated to a symbol singular along a ‐dimensional space and for multilinear variants of the Hardy‐Littlewood maximal function. When the dimension , the input functions are not necessarily in and can instead be elements of mixed‐norm spaces .Such a result has interesting consequences especially when spaces are involved. Among these, we mention mixed‐norm Loomis‐Whitney‐type inequalities for singular integrals, as well as the boundedness of multilinear operators associated to certain rational symbols. We also present examples of operators that are not susceptible to isotropic rescaling, which only satisfy “purely mixed‐norm estimates” and no classical estimates.Relying on previous estimates implied by the helicoidal method, we also prove (non‐mixed‐norm) estimates for generic singular Brascamp‐Lieb‐type inequalities.
Diagnostic value of serum NLRP3, metalloproteinase‐9 and interferon‐γ for postoperative hydrocephalus and intracranial infection in patients with severe craniocerebral trauma
Authors: Peng Qiang , Wang Lei , Yu Chun‐Mei , Chu Xin , Zhu Bao‐Feng 
Published: April 2024

AbstractTraumatic brain injury (TBI) is a major cause of morbidity and mortality globally. We unveiled the diagnostic value of serum NLRP3, metalloproteinase‐9 (MMP‐9) and interferon‐γ (IFN‐γ) levels in post‐craniotomy intracranial infections and hydrocephalus in patients with severe craniocerebral trauma to investigate the high risk factors for these in patients with TBI, and the serological factors predicting prognosis, which had a certain clinical predictive value. Study subjects underwent bone flap resection surgery and were categorized into the intracranial infection/hydrocephalus/control (without postoperative hydrocephalus or intracranial infection) groups, with their clinical data documented. Serum levels of NLRP3, MMP‐9 and IFN‐γ were determined using ELISA kits, with their diagnostic efficacy on intracranial infections and hydrocephalus evaluated by receiver operating characteristic curve analysis. The independent risk factors affecting postoperative intracranial infections and hydrocephalus were analysed by logistic multifactorial regression. The remission after postoperative symptomatic treatment was counted. The intracranial infection/control groups had significant differences in Glasgow Coma Scale (GCS) scores, opened injury, surgical time and cerebrospinal fluid leakage, whereas the hydrocephalus and control groups had marked differences in GCS scores, cerebrospinal fluid leakage and subdural effusion. Serum NLRP3, MMP‐9 and IFN‐γ levels were elevated in patients with post‐craniotomy intracranial infections/hydrocephalus. The area under the curve values of independent serum NLRP3, MMP‐9, IFN‐γ and their combination for diagnosing postoperative intracranial infection were 0.822, 0.722, 0.734 and 0.925, respectively, and for diagnosing hydrocephalus were 0.865, 0.828, 0.782 and 0.957, respectively. Serum NLRP3, MMP‐9 and IFN‐γ levels and serum NLRP3 and MMP‐9 levels were independent risk factors influencing postoperative intracranial infection and postoperative hydrocephalus, respectively. Patients with hydrocephalus had a high remission rate after postoperative symptomatic treatment. Serum NLRP3, MMP‐9 and IFN‐γ levels had high diagnostic efficacy in patients with postoperative intracranial infection and hydrocephalus, among which serum NLRP3 level played a major role.
Progresismos de segunda generación: entre el gatopardismo y las reformas sociales como cimientos de la transformación. Miradas a los gobiernos de México, Argentina y Colombia
Authors: Jimenez Martin Carolina 
Published: April 2024

Atravesamos tiempos de incertidumbres. La crisis mundial que asistimos desde 2007 y que se acentuó con la emergencia sanitaria derivada del SARS-COVID 19 ha golpeado con mucha intensidad las condiciones de existencia de las clases trabajadoras y los sectores populares y ha abierto importantes debates sobre los caminos para construir una salida. Los progresismos del siglo XXI, tanto los de primera como de segunda generación, no han estado ajenos a esta discusión. Por el contrario, han tomado un papel activo y en la mayoría de los casos se han volcado hacia la consigna de resolver la crisis. Entre las dos oleadas de gobiernos alternativos se advierten algunas diferencias, tanto de contexto, como de los desafíos que enfrentan. No es posible abordarlos desde una trayectoria de continuidad. No se trata simplemente de una segunda temporada de progresismos. Los segundos, en la mayoría, se enfrentan a unas derechas “recargadas”, a una crisis que cobra nuevos matices y a unas sociedades desesperanzadas y empobrecidas que vitalmente no dan más espera. Este artículo se interroga por las tendencias generales de política que han acompañado tres de estos gobiernos: Andrés Manuel López Obrador en México, Alberto Fernández en Argentina y más recientemente Gustavo Petro en Colombia. Y si bien no se trata de presentar unas valoraciones exhaustivas, si busca identificar algunas cuestiones que permitan indicar trayectorias y tendencias generales del proceso político vivido y en curso.
Magnetic State of Cobalt in Layered Chalcogenide Fe4Co3Se8
Authors: Piskunov Yu. V. , Ogloblichev V. V. , Sadykov A. F. , Akramov D. F. , Smolnikov A. G. , Gerashchenko A. P. , Selezneva N. V. , Baranov N. V. 
Published: April 2024

Abstract
The researches of the structural and magnetic properties of the layered chalcogenide Fe4Co3Se8, which has a ferrimagnetic order below T = 196 K, have been performed by means of X-ray diffraction, magnetic susceptibility measurements, and 59Co nuclear magnetic resonance (NMR) spectroscopy. It is found that the effective magnetic moment of iron ions is μeff ≈ 5.90(5) μB. The components of the magnetic shift and electric field gradient tensors at the Co nuclei sites have been determined. The hyperfine field induced on Co nuclei from neighboring iron ions has been estimated from the temperature dependences of the shift and susceptibility in Fe4Co3Se8. It was also established that cobalt ions in Fe4Co3Se8, as well as in the Co7Se8 compound, do not have intrinsic magnetic moment, but they do have a moment induced from neighboring iron ions
$$\mu _{{{\text{eff}}}}^{{{\text{Co}}}}$$
≈ 0.36(4) μB, which decreases at the magnetic ordering to 0.07(1)μB due to mutual compensation of contributions from neighboring iron ions.
Interaction of a quantum particle with gravitational wave in modified gravity theory
Authors: Das Rakesh , Saha Anirban 
Published: April 2024

AbstractWe present the formal solution for a quantum mechanical particle responding to gravitational wave (GW) in the framework of modified theories of gravity (MTG) where, apart from the two standard tensorial modes of polarization of GW, we have considered an additional scalar mode. The presence of this longitudinal scalar mode makes it necessary to extend the usual two-dimensional description of matter-GW interaction to a three-dimensional one. Naturally this requires non-trivial changes in the quantum mechanical treatment which we elaborate in this paper.
On the Klein–Gordon oscillators in Eddington-inspired Born-Infeld gravity global monopole spacetime and a Wu–Yang magnetic monopole
Authors: Mustafa Omar , Soares A. R. , Pereira C. F. S. , Vitória R. L. L. 
Published: April 2024

AbstractWe consider Klein–Gordon (KG) particles in a global monopole (GM) spacetime within Eddington-inspired Born–Infeld gravity (EiBI-gravity) and in a Wu–Yang magnetic monopole (WYMM). We discuss a set of KG-oscillators in such spacetime settings. We propose a textbook power series expansion for the KG radial wave function that allows us to retrieve the exact energy levels for KG-oscillators in a GM spacetime and a WYMM without EiBI-gravity. We, moreover, report some conditionally exact, closed form, energy levels (through some parametric correlations) for KG-oscillators in a GM spacetime and a WYMM within EiBI-gravity, and for massless KG-oscillators in a GM spacetime and a WYMM within EiBI-gravity under the influence of a Coulomb plus linear Lorentz scalar potential. We report the effects of the Eddington parameter $$\kappa $$
κ
, GM-parameter $$\alpha $$
α
, WYMM strength $$\sigma $$
σ
, KG-oscillators’ frequency $$\Omega $$
Ω
, and the coupling parameters of the Coulomb plus linear Lorentz scalar potential, on the spectroscopic structure of the KG-oscillators at hand. Such effects are studied over a vast range of the radial quantum number $$n_r\ge 0$$

n
r

≥
0

and include energy levels clustering at $$\kappa>>1$$

κ
>
>
1

(i.e., extreme EiBI-gravity), and at $$|\sigma |>>1$$

|
σ
|
>
>
1

(i.e., extreme WYMM strength).
Non-relativistic limit of the Mielke–Baekler gravity theory
Authors: Concha Patrick , Merino Nelson , Rodríguez Evelyn 
Published: April 2024

AbstractIn this paper, we present a generalized non-relativistic Chern–Simons gravity model in three spacetime dimensions. We first study the non-relativistic limit of the Mielke–Baekler gravity through a contraction process. The resulting non-relativistic theory contains a source for the spatial component of the torsion and the curvature measured in terms of two parameters, denoted by p and q. We then extend our results by defining a Newtonian version of the Mielke–Baekler gravity theory, based on a Newtonian like algebra which is obtained from the non-relativistic limit of an enhanced and enlarged relativistic algebra. Remarkably, in both cases, different known non-relativistic and Newtonian gravity theories can be derived by fixing the $$\left( p,q\right) $$

p
,
q

parameters. In particular, torsionless models are recovered for $$q=0$$

q
=
0

.
BCR::ABL1 kinase N-lobe mutants confer moderate to high degrees of resistance to asciminib
Authors: Leyte-Vidal Ariel , Garrido Ruiz Diego , DeFilippis RosaAnna , Leske Inga B. , Rea Delphine , Phan Stacey , Miller Kaeli B. , Hu Feifei , Mase Anjeli , Shan Yibing , Hantschel Oliver , Jacobson Matthew P. , Shah Neil P. 
Published: April 2024

Abstract
Secondary kinase domain mutations in BCR::ABL1 represent the most common cause of resistance to tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia. The first 5 approved BCR::ABL1 TKIs target the adenosine triphosphate (ATP)–binding pocket. Mutations confer resistance to these ATP-competitive TKIs and those approved for other malignancies by decreasing TKI affinity and/or increasing ATP affinity. Asciminib, the first highly active allosteric TKI approved for any malignancy, targets an allosteric regulatory pocket in the BCR::ABL1 kinase C-lobe. As a non–ATP-competitive inhibitor, the activity of asciminib is predicted to be impervious to increases in ATP affinity. Here, we report several known mutations that confer resistance to ATP-competitive TKIs in the BCR::ABL1 kinase N-lobe that are distant from the asciminib binding pocket yet unexpectedly confer in vitro resistance to asciminib. Among these is BCR::ABL1 M244V, which confers clinical resistance even to escalated asciminib doses. We demonstrate that BCR::ABL1 M244V does not impair asciminib binding, thereby invoking a novel mechanism of resistance. Molecular dynamic simulations of the M244V substitution implicate stabilization of an active kinase conformation through impact on the α-C helix as a mechanism of resistance. These N-lobe mutations may compromise the clinical activity of ongoing combination studies of asciminib with ATP-competitive TKIs.
Integrative single-cell chromatin and transcriptome analysis of human plasma cell differentiation
Authors: Alaterre Elina , Ovejero Sara , Bret Caroline , Dutrieux Laure , Sika Dassou , Fernandez Perez Raul , Espéli Marion , Fest Thierry , Cogné Michel , Martin-Subero José Ignacio , Milpied Pierre , Cavalli Giacomo , Moreaux Jérôme 
Published: April 2024

Abstract
Plasma cells (PCs) are highly specialized cells representing the end stage of B-cell differentiation. We have shown that PC differentiation can be reproduced in vitro using elaborate culture systems. The molecular changes occurring during PC differentiation are recapitulated in this in vitro differentiation model. However, a major challenge exists to decipher the spatiotemporal epigenetic and transcriptional programs that drive the early stages of PC differentiation. We combined single cell (sc) RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin with high throughput sequencing (scATAC-seq) to decipher the trajectories involved in PC differentiation. ScRNA-seq experiments revealed a strong heterogeneity of the preplasmablastic and plasmablastic stages. Among genes that were commonly identified using scATAC-seq and scRNA-seq, we identified several transcription factors with significant stage specific potential importance in PC differentiation. Interestingly, differentially accessible peaks characterizing the preplasmablastic stage were enriched in motifs of BATF3, FOS and BATF, belonging to activating protein 1 (AP-1) transcription factor family that may represent key transcriptional nodes involved in PC differentiation. Integration of transcriptomic and epigenetic data at the single cell level revealed that a population of preplasmablasts had already undergone epigenetic remodeling related to PC profile together with unfolded protein response activation and are committed to differentiate in PC. These results and the supporting data generated with our in vitro PC differentiation model provide a unique resource for the identification of molecular circuits that are crucial for early and mature PC maturation and biological functions. These data thus provide critical insights into epigenetic- and transcription–mediated reprogramming events that sustain PC differentiation.