bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of bone apposition on surface modified titanium implant in experimental animal model: A systematic review and meta-analysis
Authors: Saini Priya , Sood Shaveta , Chahal Gurparkash Singh , Jain Ashish 
Published: June 2024

Abstract:

Purpose:
To evaluate the response of peri-implant bone to smooth (machined) surface and surface-modified dental implants in healthy experimental animal models.

Materials and Methods:
Systematic electronic search was done for using PUBMED, SCOPUS, WEB OF SCIENCE, and EMBASE databases for potentially relevant records from the last 20 years. Duplicate screening and data extraction were performed to formulate the evidence tables and meta-analysis following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The outcome criteria were: 1. Bone Implant Contact (BIC) in percentage, 2. Removal Torque Values (RTV) in Ncm, 3. Implant stability Quotient (ISQ), Quality assessment was done using the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and SYRCLE RoB (Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias) tool.

Results:
Results were expressed as pooled mean difference for the respective groups viz. sandblasted and acid etched, laser modified, acid etched and anodized surface. The surface modified implants revealed somewhat higher BIC over machined surface (P < 0.01). Forest plot were drawn for all the outcome variables.

Conclusions:
Within the limitations of this study, the authors found a higher degree of osseointegration pertaining to bone to implant interface, RTV, and implant stability quotient (ISQ) with surface modified procedures which seemed to promote bone formation around peri-implant tissue during the early stages of healing. After analyzing all 37 included publications for the outcome of interest (BIC%, RTV, ISQ), a positive outcome was obtained for both subtractive and additive implant surface modifying procedures over machined implant surfaces when the data were pooled together. More advanced research work on healthy animal models needs to be investigated to review the impact of surface modifications on dental implant osseointegration.
Comparative evaluation of hard and soft tissue parameters by using short implants and standard long implants with sinus lift for prosthetic rehabilitation of posterior maxilla
Authors: Durrani Farhan , Karthickraj S. M. , Imran Fouzia , Ahlawat Shweta , Kumari Ekta , Vani S. U. Gokila 
Published: June 2024

Abstract:

Objective:
The objective is to compare and evaluate the hard and soft tissue parameters by using short and standard long implants with sinus lifting in the posterior maxilla.

Materials and Methods:
Eleven patients with complaints of missing upper back teeth were enrolled in the study for implant-supported rehabilitation and were categorized into two groups: Group long (GL): longer implant (>8 mm) placement, preceded by Sinus Augmentation. Group short (GS): short implant (≤8 mm) placement, without sinus augmentation. The primary outcome measured was cumulative survival rate (CSR) in the compromised partial edentulous posterior maxilla. Secondary outcomes measured were implant stability (IS), marginal bone level alterations (MBL), pocket probing depth (PPD), crown-to-implant ratio, and any complications.

Results:
The difference in CSR between the groups was not statistically significant (P = 0.317). High stability was achieved immediately after the placement of the implants, in both groups (GS: 64 ± 4.07, GL: 65.58 ± 9.75); this difference in the mean ISQ (IS quotients) values was not found to be statistically significant at implant placement (P = 0.7). The mean MBL reported in the study at the end of 12 months of prosthesis function was − 0.762 ± 0.48 mm and − 0.7 ± 0.34 mm for GS and GL, respectively. The mean PPD measurements in GS and GL groups were 1.917 ± 0.68 mm and 1.833 ± 0.38 mm, respectively, and it was not statistically significant (P = 0.8).

Conclusion:
Within the limitations of the present study, the obtained results indicate that short implants provided a similar clinical and radiographic performance compared to long implants placed in combination with a sinus augmentation procedure (lateral window) up to 12 months after prosthetic loading.
Convergence of inflammatory response: Salivary cytokine dynamics in coronavirus disease 2019 and periodontal disease
Authors: Gupta Shipra , Mohindra Ritin , Ramola Manisha , Kanta Poonam , Singla Mohita , Malhotra Meenakshi , Mehta Nishant , Goyal Ashima , Singh Mini P. 
Published: June 2024

Abstract:

Background:
Periodontal disease is associated with immune dysregulation, and cytokines released can add on to the coronavirus disease 2019 (COVID-19)-associated cytokine storm, further worsening the related adverse outcomes. Specific studies investigating cytokine levels in COVID-19 patients with periodontal disease are lacking. Examining the correlation between these conditions could aid in categorizing risk categories, determining referrals, and strengthening oral hygiene protocols. The current study sought to evaluate cytokine levels in the saliva of COVID-19-positive patients with and without periodontal disease.

Materials and Methods:
Twenty-six COVID-19-positive patients were subjected to periodontal examination, saliva collection, and assessment of cytokine levels through cytokine bead-based multiplex assay, using fluorescence-encoded beads with flow cytometry (BD FACS LSRFortessa). Eleven cytokines were assessed (interleukin [IL] 2, 4, 6, 10, 17A, and interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2/monocyte chemoattractant protein-1), C-X-C motif chemokine ligand (CXCL) 8/IL 8, CXCL 9/monokine-induced gamma interferon [MIG]), and CXCL 10 (chemokine IFN-gamma inducible protein 10 kDa). The cytokine levels of the recruited subjects were also compared graphically with the salivary cytokine levels reported in the literature for health, COVID-19, and periodontal disease alone.

Results:
Out of 26 COVID-19-positive patients, 17 had periodontal disease. Levels of all cytokines were raised in patients with both diseases when compared to values reported in literature for health, periodontal disease alone, or COVID-19 alone. However, there was no statistical difference among the recruited subjects for IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma, TNF-α, CCL2, CXCL 8, and CXCL 10. MIG levels were found to be higher in periodontally healthy, COVID-19-positive subjects (P = 0.01).

Conclusions:
Periodontal disease might contribute to the COVID-19-induced cytokine storm, potentially amplifying its impact.
Should general anesthesiologists be certified to perform anesthesia for patients with morbid obesity undergoing bariatric surgery: A national web-based cross-sectional survey
Authors: Ahmed Abdulaziz E. , Alaqaili Abdulaziz F. , Elbashary Ahmed S. , Bin Muammar Abdullah F. , AlQarni Adel , Yamani Nada T. , Eldawlatly Abdelazeem A. 
Published: June 2024

Background:
Bariatric surgery in Saudi Arabia has become one of the most performed surgical procedures for weight loss surgery (WLS). The aim of this survey is to highlight the importance of education and training in bariatric anesthesia (BA).

Methods:
An Internet-based cross-sectional survey was conducted to examine the percentages of general anesthesiologists among respondents who supported the need for formal structured training in BA as the primary outcome. A 41 items questionnaire on different aspects of BA included in this survey. All anesthesiologists in KSA participated in this survey.

Results:
42% responded giving anesthesia for bariatric surgery/year between 25 and 50% of cases/year. 22% responded performing 25–50 cases/month, 21% from 10–25 cases, and 14% from 50–100 cases. Compared with how many elective bariatric surgical procedures performed in your center/month revealed significant differences (P < 0.05), 39% responded with no dedicated team in their center, 14% for <10 cases a month, 9% between 25 and 50 cases a month. Compared to the number of cases performed by non-bariatric anesthetists revealed non-significant differences (P > 0.05), upon asking on how many trained/skilled anesthesiologists in bariatric anesthesia in your center, 24% reported none, 4% only one, 21% 2–5 anesthesiologists, 12% 5–10 anesthesiologists, and 19% of the respondents reported more than 10 anesthesiologists specialized in BA.

Conclusion:
We believe in education and training in bariatric anesthesia. Residents’ rotation in BA should be included in their curriculum. A dedicated fellowship program to be developed at a national level as well as courses and workshops.
Evaluation of effects of intravenous infusion of dexmedetomidine or lignocaine on stress response and postoperative pain in patients undergoing craniotomy for intracranial tumors: A randomized controlled exploratory study
Authors: Shekhar Shivam , Goyal Nishant , Mirza Anissa Atif , Agrawal Sanjay 
Published: June 2024

Background:
Goals of anesthesia in neurosurgery include stable cerebral hemodynamics and provide relaxed brain to surgeon. Dexmedetomidine and lignocaine as an adjuvant can fulfill these criteria but literature comparing the two are sparse. We compared the effects of intravenous infusion of dexmedetomidine or lignocaine on stress response, postoperative pain, and recovery in patients undergoing craniotomy for intracranial tumors.

Methods:
Approval was obtained from IEC, and the study was prospectively registered (CTRI/2022/11/047434). Written and informed consent was obtained from 105 patients fulfilling inclusion criteria, and they were divided into three groups. Group D received intravenous infusion of dexmedetomidine 1 mcg/kg over 15 minutes followed by infusion at rate of 0.5 mcg/kg/h, Group L received intravenous infusion of lignocaine 2 mg/kg over 15 minutes followed by infusion at rate of 1.5 mg/kg/h, and Group N received intravenous infusion of normal saline at the rate of 4–8 ml/h till skin suturing. SPSS v23 (IBM Corp.) was used for data analysis.

Results:
There was a significant difference between groups in terms of intraoperative hemodynamic variations, brain relaxation score, extubation criteria, postoperative pain, stress indicator response, and quality of recovery.

Conclusions:
Dexmedetomidine as an adjuvant to anesthetic drugs has a better profile than lignocaine in suppressing stress response and preventing hemodynamic variations at intubation, skull pin application, and surgical incision. Dexmedetomidine increases the duration of effective analgesia more than lignocaine, in postoperative period in patients undergoing craniotomy.
Precision in practice: An audit study on low-flow anesthesia techniques with desflurane and sevoflurane for cost-effective and sustainable care
Authors: Chowdappa Gopinath Kenkare , Iolov Svetoslav Ivanov , Abuamra Khaled Saleh , Kulkarni Prasad Padmakar , Shariff Jameelulla Aleemulla , Abdelaziz Hatem Mohammed Khairy , Kumar Justin Arun 
Published: June 2024

Introduction:
In the backdrop of escalating healthcare costs and an increasing focus on resource optimization, this audit study delves into the realm of anesthesia management, specifically exploring the application of low-flow anesthesia (LFA). The primary objective was to assess adherence to hospital standards and evaluate the economic implications of LFA (<1 L/min).

Materials and Methods:
This retrospective audit focused on 700 adult patients undergoing elective surgeries with general anesthesia. Data sources included anesthesia records, electronic recording systems, and audits by a dedicated team. Fresh gas flow rates (FGFRs), minimum alveolar concentration (MAC), and volatile anesthetic consumption were analyzed. Cost comparisons between low-flow and high-flow anesthesia were conducted, employing specific cost per milliliter metrics.

Results:
The average FGFR during the maintenance phase was found to be 0.45 ± 0.88 L/min. Adherence to hospital standards was notably high, with 94.29% of patients being maintained on low-flow gas rates. The differences in anesthetic consumption between low-flow and high-flow FGFR were statistically significant for both desflurane (12.17 ± 10.84 ml/MAC hour versus 43.12 ± 27.25 ml/MAC hour) and sevoflurane (3.48 ± 7.22 ml/MAC hour versus 5.20 ± 5.20 ml/MAC hour, P < 0.001). The calculated savings per patient with low-flow desflurane and sevoflurane anesthesia compared to high flow were found to be 109.25 AED and 6.74 AED, respectively.

Conclusion:
This audit advocates for the widespread adoption of LFA as a standard practice. Beyond aligning with hospital standards, the study highlights the multi-faceted benefits of LFA, encompassing economic savings, environmental safety, and enhanced patient care.
An in vitro technique to measure resistance to compression and kinking of endotracheal tubes
Authors: Young Emily , Nocera Tonya M. , Reilly Matthew , Tobias Joseph D. , D’Mello Ajay 
Published: June 2024

Background:
During intraoperative care, ventilatory parameters including peak inflating pressure (PIP) and exhaled tidal volumes are continuously monitored to assess changes in respiratory resistance and compliance. Changes in these parameters, such as an increase in PIP or a decrease in the exhaled tidal volume, may indicate various pathologic processes that may require immediate attention to prevent inadequate ventilation resulting in hypoxemia or hypercarbia. A kinked endotracheal tube (ETT) may mimic other pathologic processes including bronchospasm, mainstem intubation, or ventilator malfunction. As newer ETTs are developed, a key factor in their design should be resistance to kinking or occlusion due to patient positioning.

Methods:
The current project developed and describes the process for using a repeatable in vitro mechanical test to determine resistance to kinking by an ETT.

Results:
The mechanical testing procedure can be used to determine the compression force and distance required to kink an ETT under different conditions including temperature. The force required to induce devastating kink failure was lower during heated testing conditions. The addition of airflow through the ETTs during compression testing confirms the occurrence of airway obstruction at approximately the same time a mechanical kink is observed on the force-versus-distance curves.

Conclusions:
These procedures may be used to characterize and evaluate ETT designs under in vitro conditions mimicking those in the clinical practice.
Endotracheal tube cuff position in relationship to the walls of the trachea: A retrospective computed tomography-based analysis
Authors: Wani Tariq M. , Siddique Ayesha Y. , Khan Wajahat N. , Rehman Saif , Tram Nguyen K. , Tobias Joseph D. 
Published: June 2024

Background:
The use of cuffed endotracheal tubes (ETTs) has become the standard of care in pediatric practice. The rationale for the use of a cuffed ETT is to minimize pressure around the cricoid while providing an effective airway seal. However, safe care requires that the cuff lie distal to the cricoid ring following endotracheal intubation. The current study demonstrates the capability of computed tomography (CT) imaging in identifying the position of the cuff of the ETT in intubated patients.

Methods:
The study included patients ranging in age from 1 month to 10 years who underwent neck and chest CT imaging that required general anesthesia and endotracheal intubation. The location of the ETT and of the cuff within the airway was determined from axial CT images at three levels (proximal, middle, and distal). Anatomical orientations were tabulated, and percent chances of each orientation were determined for the ETT and the cuff.

Results:
The study cohort included 42 patients ranging in age from 1 to 114 months. An ETT with a polyvinylchloride cuff was used in 24 patients, and an ETT with a polyurethane cuff was used in 18 patients. The ETT was located near the posterior wall of the trachea in approximately 24–38% of patients, being most likely to be centrally located at the proximal end and at its mid-portion. The middle part of the cuff was most likely to be positioned in the mid-portion of the trachea but tended to skew anteriorly at both the proximal and distal ends.

Conclusion:
This is the first study using CT imaging to identify the uniformity of cuff inflation within the trachea in children. With commonly used cuffed ETTs, cuff inflation and the final position of ETT cuff within the tracheal lumen were not uniform. Future investigations are needed to determine the reasons for this asymmetry and its clinical implications.
Characterization of Leuconostoc lactis Bacteremia during a 2-year Study at a Tertiary Care Center in North India—An Observational Analysis
Authors: Tripathy Sarvodaya , Jamwal Ashima , Varghese Gerlin , Sarawat Deepika , Patel Sangram Singh , Tejan Nidhi , Sahu Chinmoy 
Published: June 2024

ABSTRACT.
Leuconostoc species are regarded as important causes for many infections in immunocompromised patients. In this study, we assessed the characteristics of Leuconostoc spp. causing bacteremia in patients at our center. This observational analysis was conducted in the microbiology laboratory of a tertiary care center in northern India from July 2021 to July 2023. Patients in whom blood culture bottles were positive for Leuconostoc lactis were included in the study. Culture isolates were identified by MALDI-ToF MS as L. lactis and tested for antibiotic sensitivity results by Kirby–Bauer disk diffusion method. Demographic and clinical details were collected and analyzed. During the study period, 6,742 blood culture bottles flagged positive. Among these, L. lactis was isolated from 14 (0.21%) patients. The median patient age was 34 years. The male-to-female ratio was 2.5:1. All the patients with L. lactis bacteremia had an underlying condition leading to immunosuppression (e.g., carcinoma and chronic kidney disease). All the patients with L. lactis bacteremia had an intravascular device present at the time of bacteremia. All isolates in the study were sensitive to doxycycline, high level gentamicin, minocycline, ampicillin-sulbactam, and linezolid. Mortality was attributed to bacteremia by L. lactis in five patients. Appropriate and timely identification of the Leuconostoc species is important for the clinician to tailor regimens for the patients.
Testing the aphrodisiac effects of Sterculia quadrifida (faloak) bark powder on male white rats (Rattus norvegicus)
Authors: Sambara Jefrin , Yuliani Ni Nyoman , Upa Muhamad Satria Pua , Rahmat Emanuel Gerald Alan 
Published: June 2024

Background: Sterculia quadrifida R.Br has been widely known and, empirically, has been widely used as an herbal ingredient to overcome sexual disorders in men.
Objective: This study aims to assess the quality, stability, and aphrodisiac properties of faloak bark solution preparations (from plants R.Br Sterculia quadrifida) found on Timor Island, specifically on male white rats of the Wistar strain.
Method: This research is a type of experimental research. The activity test used two variations of the formula (50%, 100%) extract, positive and negative control tests. Data were analysed with one-way ANOVA (p < 0.05).
Result: The test results of extract quality and stability, including moisture content, resting angle, flow speed, dissolving time, organoleptic test, pH, specific gravity, clarity, and homogeneity, met the requirements. The analysis results found significant differences in each test group (p < 0.05), and there were substantial differences between the negative control group and the positive control group, formula one and formula two.
Conclusion: The preparation of the solution of Sterculia quadrifida R. met the established quality and stability. The results of the aphrodisiac test of the effect of Sterculia quadrifida R.Br on the parameters of introduction and climbing activity showed significant activity compared to the negative control group.
Efecto de la introducción de plantas biocidas en un monocultivo de tomate valenciano y análisis de la técnica del injerto
Authors: Baixauli Carlos , Giner Alfonso , Aguilar José Mariano , Burguet Resurrección 
Published: June 2024

With the development of this experience during several consecutive campaigns, the aim was to evaluate, in the medium term, the effect of using biocidal plants in combination with a tomato monoculture, as well as the effect of using a tolerant tomato rootstock in a local selection of Valencian tomato. The experience was carried out at the Centro de Experiencias de Cajamar in Paiporta (Valencia). The commercial production, the waste production and the average weight of commercial fruits were analyzed, as well as agronomic aspects of the plant during and at the end of the crop. Furthermore, in each campaign, soil analyzes were carried out prior to planting the tomato to see the evolution of some physical, chemical and biological parameters of interest. The results of the trial showed that the use of biocidal plants in the crop rotation reduced the nodules index produced by nematodes on the roots of the plants and slightly increased the levels of organic matter, although it had no clear effects on the rest of the parameters studied; in addition, the use of grafted plants improved the average weight of the fruit and some vegetative development and agronomic aspects of the plants.----------------------------Con el desarrollo de esta experiencia durante varias campañas consecutivas se evaluó, a medio plazo, el efecto de la utilización de las plantas biocidas en combinación con un monocultivo de tomate, así como el efecto de la utilización de un portainjerto de tomate tolerante en una selección local de tomate valenciano. La experiencia se desarrolló en el Centro de Experiencias de Cajamar en Paiporta (Valencia). Se analizó la producción comercial, producción de destrío y el peso medio de los frutos comerciales, así como aspectos agronómicos de la planta durante y al final del cultivo. Además, en cada campaña se realizaron, previo a la plantación del tomate, unas analíticas de suelo para ver la evolución de algunos parámetros físicos, químicos y biológicos de interés. Los resultados obtenidos han mostrado que la utilización de plantas biocidas en la rotación del cultivo redujo el índice de nodulación producidos por nemátodos en las raíces de las plantas y aumentó ligeramente los niveles de materia orgánica, aunque no tuvo efectos claros sobre el resto de los parámetros estudiados; además la utilización de planta injertada mejoró el peso medio de los frutos y algunos aspectos de desarrollo y agronómicos de las plantas.