bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of ACE inhibitor/ARB therapy and long COVID on kidney disease: a retrospective cohort study using real-world data
Authors: Zhang Yue , Ba Djibril M , Risher Kathryn , Liao Duanping , Parent Leslie J , Ghahramani Nasrollah , Chinchilli Vernon M 
Published: June 2024

ABSTRACT

Background
The association between angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and severe acute respiratory syndrome coronavirus 2 susceptibility, particularly via ACE-2 receptor upregulation in the kidneys, raises concerns about potential kidney disease risks in long coronavirus disease (COVID) patients. This study explores the association of ACEI/ARB therapy on acute kidney injury (AKI), chronic kidney disease (CKD) and all-cause mortality in patients with and without long COVID.

Methods
A retrospective cohort study using TriNetX datasets was conducted, with diagnoses of long COVID via International Classification of Diseases, Tenth Revision (ICD-10) codes and prescription for ACEI/ARB as the classification of four cohorts: long COVID ACEI/ARB users (LCAUs), long COVID ACEI/ARB non-users (LCANs), non-long COVID ACEI/ARB users (NLCAUs) and non-long COVID ACEI/ARB non-users (NLCANs). Multivariable stratified Cox proportional hazards regression models assessed the adjusted hazard ratios (aHRs) across groups. Additional analyses were conducted, including time-dependent exposure analysis and comparison with an active comparator, calcium channel blockers.

Results
Our study included 18 168 long COVID and 181 680 propensity score-matched non-long COVID patients from October 2021 to October 2023. ACEI/ARB use did not significantly affect the risk of AKI or CKD when comparing LCAUs with LCANs and NLCAUs with NLCANs. However, a protective effect against all-cause mortality was observed {aHR 0.79 [95% confidence interval (CI) 0.65–0.93]} in the NLCAU group compared with the NLCAN group. Conversely, long COVID was associated with increased risks of CKD [aHR 1.49 (95% CI 1.03–2.14)] and all-cause mortality [aHR 1.49 (95% CI 1.00–2.23)] when comparing LCANs with NLCANs. The additional analyses support the primary findings.

Conclusions
ACEI/ARB treatment does not increase the incidence of CKD or AKI, regardless of long COVID status. However, long COVID itself is associated with increasing risks of kidney diseases and all-cause mortality.
Genomic variation across distribution of Micro-Tom, a model cultivar of tomato (Solanum lycopersicum)
Authors: Nagasaki Hideki , Shirasawa Kenta , Hoshikawa Ken , Isobe Sachiko , Ezura Hiroshi , Aoki Koh , Hirakawa Hideki 
Published: June 2024

Abstract
Micro-Tom is a cultivar of tomato (Solanum lycopersicum), which is known as a major crop and model plant in Solanaceae. Micro-Tom has phenotypic traits such as dwarfism, and substantial EMS-mutagenized lines have been reported. After Micro-Tom was generated in Florida, USA, it was distributed to research institutes worldwide and used as a genetic resource. In Japan, the Micro-Tom lines have been genetically fixed; currently, three lines have been re-distributed from three institutes, but many phenotypes among the lines have been observed. We have determined the genome sequence de novo of the Micro-Tom KDRI line, one of the Micro-Tom lines distributed from Kazusa DNA Research Institute (KDRI) in Japan, and have built chromosome-scale pseudomolecules. Genotypes among six Micro-Tom lines, including three in Japan, one in the United States, one in France, and one in Brazil showed phenotypic alternation. Here, we unveiled the swift emergence of genetic diversity in both phenotypes and genotypes within the Micro-Tom genome sequence during its propagation. These findings offer valuable insights crucial for the management of bioresources.
A haplotype-resolved reference genome of a long-distance migratory bat, Pipistrellus nathusii (Keyserling & Blasius, 1839)
Authors: Driller Maximilian , Brown Thomas , Currie Shannon E , Hiller Michael , Winkler Sylke , Pippel Martin , Voigt Christian C , Fickel Jörns , Mazzoni Camila J 
Published: June 2024

Abstract
We present a complete, chromosome-scale reference genome for the long-distance migratory bat Pipistrellus nathusii. The genome encompasses both haplotypic sets of autosomes and the separation of both sex chromosomes by utilizing highly accurate long-reads and preserving long-range phasing information through the use of three-dimensional chromatin conformation capture sequencing (Hi-C). This genome, accompanied by a comprehensive protein-coding sequence annotation, provides a valuable genomic resource for future investigations into the genomic bases of long-distance migratory flight in bats as well as uncovering the genetic architecture, population structure and evolutionary history of Pipistrellus nathusii. The reference-quality genome presented here gives a fundamental resource to further our understanding of bat genetics and evolution, adding to the growing number of high-quality genetic resources in this field. Here, we demonstrate its use in the phylogenetic reconstruction of the order Chiroptera, and in particular, we present the resources to allow detailed investigations into the genetic drivers and adaptations related to long-distance migration.
Impact of pre-existing mesh at the hiatus at revisional hiatal hernia surgery
Authors: Barazanchi Ahmed W H , Chui Juanita Noeline , Bhimani Nazim , Leibman Steven , Smith Garett 
Published: June 2024

Summary
Recurrence after laparoscopic hiatus hernia repair (LHR) is high, with few symptomatic patients undergoing redo LHR. Morbidity is higher in redo surgery compared with the primary operation. Tens of studies have explored the safety of redoing LHR. However, the impact of existing mesh on operative risk is rarely examined. We aim to assess the impact of mesh at the hiatus on the safety of redo LHR. This was a cohort study examining redo LHR patients from a prospectively maintained database from January 2002 to December 2023. The primary outcome was intra-/postoperative complications. Follow-up was extracted from clinical records. Predictors of complications were assessed using univariable and multivariable logistic regression analyses. Redo LHR was performed in 100 patients; 22 had previous mesh. One encountered mortality with 23 complications. Five patients had absorbable mesh, with the remainder nonabsorbable. Overall complications were significantly higher with mesh at nine (40.9%) compared to no mesh redo at 14 (17.9%), P = 0.023. There was no difference in rates of visceral injury with mesh at four (18.2%) and no mesh at six (7.7%), P = 0.22. The median follow-up was 7 months; there was no difference in reflux rates (P = 0.70) but higher rates of dysphagia (P = 0.010). Higher overall complications were noted in patients with previous hiatal mesh repair at the time of LHR. However, major visceral complications were similar regardless of mesh use. Mesh at the hiatus should not be a deterrent for reoperative hiatus surgery.
Oral anticoagulation in patients with left ventricular thrombus: a systematic review and meta-analysis
Authors: Haller Paul M , Kazem Niema , Agewall Stefan , Borghi Claudio , Ceconi Claudio , Dobrev Dobromir , Cerbai Elisabetta , Grove Erik Lerkevang , Kaski Juan Carlos , Lewis Basil S , Niessner Alexander , Rocca Bianca , Rosano Giuseppe , Savarese Gianluigi , Schnabel Renate B , Semb Anne Grete , Sossalla Samuel , Wassmann Sven , Sulzgruber Patrick 
Published: June 2024

Abstract

Aims
Direct oral anticoagulants (DOACs) are increasingly used off-label to treat patients with left ventricular thrombus (LVT). We analysed available meta-data comparing DOACs and vitamin K antagonists (VKAs) for efficacy and safety.

Methods
We conducted a systematic search and meta-analysis of observational and randomized data comparing DOACs vs. VKAs in patients with LVT. Endpoints of interest were stroke or systemic embolism, thrombus resolution, all-cause death, and a composite bleeding endpoint. Estimates were pooled using a random-effects model meta-analysis, and their robustness was investigated using sensitivity and influential analyses.

Results
We identified 22 articles (18 observational studies, 4 small randomized clinical trials) reporting on a total of 3587 patients (2489 VKA vs. 1098 DOAC therapy). The pooled estimates for stroke or systemic embolism [odds ratio (OR): 0.81; 95% confidence interval (CI): 0.57, 1.15] and thrombus resolution (OR: 1.12; 95% CI: 0.86, 1.46) were comparable, and there was low heterogeneity overall across the included studies. The use of DOACs was associated with lower odds of all-cause death (OR: 0.65; 95% CI: 0.46, 0.92) and a composite bleeding endpoint (OR: 0.67; 95% CI: 0.47, 0.97). A risk of bias was evident particularly for observational reports, with some publication bias suggested in funnel plots.

Conclusion
In this comprehensive analysis of mainly observational data, the use of DOACs was not associated with a significant difference in stroke or systemic embolism, or thrombus resolution, compared with VKA therapy. The use of DOACs was associated with a lower rate of all-cause death and fewer bleeding events. Adequately sized randomized clinical trials are needed to confirm these findings, which could allow a wider adoption of DOACs in patients with LVT.
Minimal clinically important differences in patient-reported outcomes after coronary artery bypass surgery in the arterial revascularization trial
Authors: Masterson Creber Ruth , Dimagli Arnaldo , Niño de Rivera Stephanie , Russell David , Gerry Stephen , Lees Belinda , Guazzelli Alice , Flather Marcus , Taggart David P , Gray Alastair , Gaudino Mario 
Published: June 2024

Abstract

OBJECTIVES
This article identifies minimal clinically important differences (MCIDs) in quality of life (QoL) measures among patients who had coronary artery bypass grafting (CABG) and were enrolled in the arterial revascularization trial (ART).

METHODS AND RESULTS
The European Quality of Life-5 Dimensions (EQ-5D) and the Short Form Health Survey 36-Item (SF-36) physical component (PC) and mental component (MC) scores were recorded at baseline, 5 years and 10 years in ART. The MCIDs were calculated as changes in QoL scores anchored to 1-class improvement in the New York Heart Association functional class and Canadian Cardiovascular Society scale at 5 years. Cox proportional hazard models were used to evaluate associations between MCIDs and mortality. Patient cohorts were examined for the SF-36 PC (N = 2671), SF-36 MC (N = 2815) and EQ-5D (N = 2943) measures, respectively. All QoL scores significantly improved after CABG compared to baseline. When anchored to the New York Heart Association, the MCID at 5 years was 17 (95% confidence interval: 17–20) for SF-36 PC, 14 (14–17) for the SF-36 MC and 0.12 (0.12–0.15) for EQ-5D. Using the Canadian Cardiovascular Society scale as an anchor, the MCID at 5 years was 15 (15–17) for the SF-36 PC, 12 (13–15) for the SF-36 MC and 0.12 (0.11–0.14) for the EQ-5D. The MCIDs for SF-36 PC and EQ-5D at 5 years were associated with a lower risk of mortality at the 10-year follow-up point after surgery.

CONCLUSIONS
MCIDs for CABG patients have been identified. These thresholds may have direct clinical applications in monitoring patients during follow-up and in designing new trials that include QoL as a primary study outcome.

Clinical trial registration number
ISRCTN46552265.
State-of-the-art pulsed field ablation for cardiac arrhythmias: ongoing evolution and future perspective
Authors: Chun Kyoung-Ryul Julian , Miklavčič Damijan , Vlachos Konstantinos , Bordignon Stefano , Scherr Daniel , Jais Pierre , Schmidt Boris 
Published: June 2024

Abstract
Pulsed field ablation (PFA) is an innovative approach in the field of cardiac electrophysiology aimed at treating cardiac arrhythmias. Unlike traditional catheter ablation energies, which use radiofrequency or cryothermal energy to create lesions in the heart, PFA utilizes pulsed electric fields to induce irreversible electroporation, leading to targeted tissue destruction. This state-of-the-art review summarizes biophysical principles and clinical applications of PFA, highlighting its potential advantages over conventional ablation methods. Clinical data of contemporary PFA devices are discussed, which combine predictable procedural outcomes and a reduced risk of thermal collateral damage. Overall, these technological developments have propelled the rapid evolution of contemporary PFA catheters, with future advancements potentially impacting patient care.
Gene Protein Sequence Evolution Can Predict the Rapid Divergence of Ovariole Numbers in the Drosophila melanogaster Subgroup
Authors: Whittle Carrie A , Extavour Cassandra G 
Published: June 2024

Abstract
Ovaries play key roles in fitness and evolution: they are essential female reproductive structures that develop and house the eggs in sexually reproducing animals. In Drosophila, the mature ovary contains multiple tubular egg-producing structures known as ovarioles. Ovarioles arise from somatic cellular structures in the larval ovary called terminal filaments (TFs), formed by TF cells and subsequently enclosed by sheath (SH) cells. As in many other insects, ovariole number per female varies extensively in Drosophila. At present, however, there is a striking gap of information on genetic mechanisms and evolutionary forces that shape the well-documented rapid interspecies divergence of ovariole numbers. To address this gap, here we studied genes associated with Drosophila melanogaster ovariole number or functions based on recent experimental and transcriptional datasets from larval ovaries, including TFs and SH cells, and assessed their rates and patterns of molecular evolution in five closely related species of the melanogaster subgroup that exhibit species-specific differences in ovariole numbers. From comprehensive analyses of protein sequence evolution (dN/dS), branch-site positive selection, expression specificity (tau), and phylogenetic regressions (phylogenetic generalized least squares), we report evidence of 42 genes that showed signs of playing roles in the genetic basis of interspecies evolutionary change of Drosophila ovariole number. These included the signaling genes upd2 and Ilp5 and extracellular matrix genes vkg and Col4a1, whose dN/dS predicted ovariole numbers among species. Together, we propose a model whereby a set of ovariole-involved gene proteins have an enhanced evolvability, including adaptive evolution, facilitating rapid shifts in ovariole number among Drosophila species.
The Shape of Water: Physiological Adaptations to Habitat Aridity in the Ornate Tree Lizard (Urosaurus ornatus)
Authors: Salazar Jhan C , Miles Donald B 
Published: June 2024

Synopsis
Deserts have always amazed researchers due to their high diversity of habitats, where plant and animal species have been able to adapt and diversify, even when these areas impose several constraints on an organism’s activity patterns. In particular, deserts support several lizard species adapted to the thermal and water restrictions found in such biomes. Although several studies have attempted to understand how lizard species might respond to water deficits or droughts in deserts, few have addressed how these responses might vary along a latitudinal gradient. This raises the question of whether physiological buffering of the organism or the climatic environment affects water loss in lizards. Here, we used six populations of Urosaurus ornatus to test whether water loss is influenced more by the intrinsic physiology of the lizard or by the climatic niche. We found that water loss is primarily influenced by the climatic niche of the lizard. However, future studies should focus on how microclimatic variables can influence water loss in organisms found across large latitudinal gradients.
Deep neural network for investment decision planning on low-carbon transition in power grid
Authors: Wang Min , Wang Yixiao , Chen Bobo , Chen Yunhui 
Published: June 2024

AbstractWith the urgency of mitigating global warming, the low-carbon transformation of power grid systems has emerged as a pivotal industry upgrade for sustainable development. We proposed a novel deep neural network-based approach for investment decision planning in the low-carbon transformation of power grids, which aimed to address multidimensional key indicators related to power grid transformation and provided reliable electricity industry layouts and investment plans for power system investment decisions. To achieve this, three targeted investment branch models were established, encompassing investment behavior, electricity production and consumption, and predictions of new capacity investment. These models effectively tackled challenges associated with power distribution, electricity price scheduling, power carbon quotas, and the feasibility of low-carbon power generation technologies. Subsequently, a global investment decision planning model was constructed, employing spatiotemporal neural networks and recurrent neural networks, which integrated the aforementioned branch models and incorporated existing low-carbon transformation data. A comparative analysis was conducted, examining the predicted results against actual values from three perspectives: power generation portfolio, grid economy, and overall investment decision plans. The results demonstrated the effectiveness of our method in accurately predicting future installed capacity of diverse low-carbon power generation technologies, sustainability indices, and investment returns. Notably, our method achieves an impressive forecasting accuracy of over 90% compared to actual values of investment decision planning over the past 4 years.
Experimental study on the effect of hot air supply mode on the performance of air-source heat pump with enhanced vapor injection
Authors: Huang Chunhui , Du Yongheng , Huo Ziheng , Ding Chuangchuang , Zai Saina , Zhang Zhan , Meng Zhaofeng 
Published: June 2024

Abstract
In order to improve the operation efficiency of air-source heat pump with enhanced vapor injection (EVI), a hot air–EVI air-source composite heat pump test bench was built. Rear air supply mode and a more uniform hood air supply mode were employed. The experimental results demonstrate that, compared to the rear air supply mode, the compressor power consumption in the hood air supply mode can be reduced by 1.6%–4.6%. Simultaneously, the heating capacity experiences an increase of 1.2%–4.6%, and the coefficient of performance is elevated by 3.1–8.7%. The exhaust temperature decreased by 1.74%. Moreover, the exhaust pressure in the hood air supply mode is decreased to a certain extent. These experimental findings not only offer a dependable air supply mode transformation scheme but also furnish essential data support for solar energy–EVI air-source composite heat pumps, showcasing promising applications in cold regions.
Ethical, legal, and policy challenges in field-based neuroimaging research using emerging portable MRI technologies: guidance for investigators and for oversight
Authors: Shen Francis X , Wolf Susan M , Lawrenz Frances , Comeau Donnella S , Dzirasa Kafui , Evans Barbara J , Fair Damien , Farah Martha J , Han S Duke , Illes Judy , Jackson Jonathan D , Klein Eran , Rommelfanger Karen S , Rosen Matthew S , Torres Efraín , Tuite Paul , Vaughan J Thomas , Garwood Michael 
Published: June 2024

Abstract
Researchers are rapidly developing and deploying highly portable MRI technology to conduct field-based research. The new technology will widen access to include new investigators in remote and unconventional settings and will facilitate greater inclusion of rural, economically disadvantaged, and historically underrepresented populations. To address the ethical, legal, and societal issues raised by highly accessible and portable MRI, an interdisciplinary Working Group (WG) engaged in a multi-year structured process of analysis and consensus building, informed by empirical research on the perspectives of experts and the general public. This article presents the WG’s consensus recommendations. These recommendations address technology quality control, design and oversight of research, including safety of research participants and others in the scanning environment, engagement of diverse participants, therapeutic misconception, use of artificial intelligence algorithms to acquire and analyze MRI data, data privacy and security, return of results and managing incidental findings, and research participant data access and control.
Patterns of acorn selection in Peromyscus mice and possible implications in a changing climate
Authors: Franzoi Dri Gabriela , Hunter Malcolm , Mortelliti Alessio 
Published: June 2024

Abstract
Rodents play a key role in forest regeneration by dispersing seeds and interspecific differences in seed preferences could have important consequences for forest growth. The White-footed Mouse (Peromyscus leucopus) and Deer Mouse (Peromyscus maniculatus gracilis) are 2 closely related species that can exploit Red Oak (Quercus rubra) acorns but may display different preference levels due to the high tannin concentration present in these acorns. Here we investigated how White-footed Mice and Deer Mice differ in their ability to exploit Red Oak acorns. We conducted a cafeteria-style experiment where we offered mice (n = 61) acorns of Red Oak and Bur Oak (Q. macrocarpa; control seed with lower tannin levels) and video-recorded their preference and the acorn fate (consumed or cached). Using mixed-effects models, we found that both mouse species selected and consumed Bur Oak acorns at a high rate; however, White-footed Mice were 6.67 times more likely to select and consume Red Oak acorns than Deer Mice. Furthermore, White-footed Mice tended to cache Red Oak acorns near the surface where there is a higher chance of germination, while they usually consumed Bur Oak acorns. Our results suggest that Red Oaks have a better strategy for avoiding predation than Bur Oaks (i.e., high tannin levels leading to caching), and the strong interaction between the White-footed Mouse and Red Oak might be an important mechanism behind the current range expansion of both species in response to climate change.
Resolving confusion in the native distribution of Aedes (Hulecoeteomyia) koreicus (Diptera: Culicidae)
Authors: Seok Sangwoo , Mogi Motoyoshi , Lee Yoosook 
Published: June 2024

Abstract
Recent studies on invasive Aedes koreicus (Edwards 1917) have been conducted to elucidate the source population introduced to Europe. However, current information about the native range of Ae. koreicus is not consistent. The purpose of this study is to resolve confusion in the native distribution of Ae. koreicus by reviewing available literature from the first description of the species in its native range in 1917 to the first invasion in Europe in 2008. Aedes koreicus have been recorded in China, Japan, Korea, and eastern Russia. The 2 existing records of Ae. koreicus from Hokkaido, Japan, however, is likely due to the misidentification of 2 different morphologically similar species, Ae. koreicoides (Sasa, Kano & Hayashi 1950) and Aedes japonicus (Theobald 1901). Upon re-examination of published records, we conclude that the native distribution of Ae. koreicus is confined to continental eastern Asian regions, specifically China, Korea, and eastern Russia.