bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on bionic bouncing foot of a lunar environment jumping robot
Authors: Zhang Rui , 栗 熙程 , Li Tao , Tang Jiaqi , Zhang Hua , Wang Weijun , Hu Zhenyu , Wen Lige 
Published: April 2024

Abstract

In the current study, we have designed a bouncing device, the bionic bouncing foot end, specifically for the lunar surface environment. The device uses its gravity to store energy in a spring and bounces when the spring releases the energy. We released the spring device from a fixed height and used a 3D capture device to record and analyse the height and angle of excursion of the foot to assess its bouncing performance. Given the important influence of the attachment performance of the foot end on the jumping performance, we designed a new bionic pattern of the bouncing foot end using the camel hoof and the ostrich papilla as bionic prototypes. Through validation, we demonstrated that the attachment performance of the bionic pattern is better than that of the traditional patterned foot end. For the application requirements of jumping robots in loose and soft media, we further optimised the design of the foot end pattern and verified it by simulation through multi-rigid body dynamics and discrete element simulation. These studies provide important theoretical and technical support for the study of high-performance jumping robots in the lunar surface environment.
Revitalizing Cultural Heritage: Designing Attractive Virtual Museum In The Metaverse
Authors: Aziz Omer , Farooq Muhammad Shoaib , khelifi Adel , Shoaib Mahdia 
Published: April 2024

Abstract

The rapid evolution of the digital landscape has catalyzed the integration of blockchain technology within the domain of cultural heritage, particularly in virtual museums within the Metaverse. This study introduces ArchaeoMeta, a novel framework designed to leverage blockchain technology to enhance security, authenticity, and visitor interaction in a virtual museum environment. Deployed on Ethereum testnet, the framework utilizes smart contracts to manage visitor interactions and secure digital artifacts, aiming to resolve challenges associated with scalability and user experience under varying loads. The performance evaluation was conducted by simulating user interactions, scaling up to ten thousand concurrent users to assess the impact on transaction latency, gas usage, and blockchain size. The findings reveal significant scalability challenges as transaction latency and blockchain size increased with the number of users, highlighting areas for optimization in managing high user traffic within the blockchain infrastructure. This study contributes to the understanding of blockchain applications in cultural heritage, suggesting that while ArchaeoMeta offers a robust platform for virtual museums, enhancements in scalability through layer-2 solutions or alternative blockchain platforms are essential for its practical implementation. The framework sets a precedent for future research in the convergence of blockchain technology and cultural heritage preservation, promising a transformative impact on how digital cultural experiences are curated and consumed.
Uncovering the Motivations and Barriers for Suppliers in Adopting Sustainable Practices
Authors: Reynolds Samantha 
Published: April 2024

Abstract
This qualitative research investigates the motivations and barriers for suppliers in adopting sustainable practices within supply chains. Through semi-structured interviews with 20 suppliers from diverse industries and geographic locations, key themes emerge regarding supplier engagement with sustainability. The findings highlight the complex interplay of internal and external factors shaping supplier behavior, including competitive dynamics, stakeholder pressures, organizational factors, and supply chain complexities. Motivations for supplier engagement with sustainability encompass competitive advantage, financial benefits, stakeholder pressure, and internal values. However, suppliers face significant barriers, such as financial constraints, organizational inertia, and supply chain complexities, hindering their ability to adopt and implement sustainable practices effectively. The implications of these findings extend to both practice and policy, with recommendations for firms to develop tailored strategies and interventions to support suppliers in their sustainability journey. Policymakers can use the insights to inform regulatory frameworks and industry standards that promote sustainability across supply chains, fostering collaboration and knowledge sharing among stakeholders to drive collective action on sustainability initiatives. By addressing these factors effectively, stakeholders can unlock the potential for sustainable supply chain management to drive positive environmental, social, and economic outcomes, advancing the broader agenda of sustainable development.
Exosomes from Taenia solium cysticerci impairs PI3K-AKT-mTOR pathway and induces apoptosis in macrophages
Authors: rawat Suraj S , Keshri Anand , Arora Naina , Kaur Rimanpreet , Prasad Amit 
Published: April 2024

Abstract
Exosomes are extracellular vesicles of 30-100nm which constitutes significant part of secretome. Excretory secretory proteome plays significant role in pathogenesis and immune escapes mechanisms of complex parasites like Taenia solium. The cyst of T. solium causes infection to CNS i.e., neurocysticercosis (NCC) a neglected tropical disease. However, the role of exosomes in NCC pathogenesis is not understood till now. Here for the first time, we report exosomes- induce AKT degradation in macrophages via the autophagosomal-lysosomal pathway but not via the proteasomal pathway. The phenotype is supported by the low ROS production with impaired bacterial killing. Along with this PI3K pathway was also seen to be impaired after exosome stimulation in macrophages. We also found mTOR degradation was via the lysosomal pathway with a notable increase in the ubiquitination. Following this autophagy and apoptosis both increased with significant degradation of autophagy substrate SQSTM1. In summary, here we report that the T. solium exosomes modulate PI3K-AKT-mTOR pathway to induce autophagy and apoptosis in macrophages and this may exert immunosuppression via the exosomes during NCC disease. These finding helps us to understand the immune suppression induced by cyst for its survival in host.
Leveraging Machine Learning for Accurate Groundnut Price Forecasting in Tamil Nadu: An XGboost Approach
Authors: Mantaw Chow Suliyaa , M Prahadeeswaran 
Published: April 2024

Abstract
Accurate forecasting of agricultural commodity prices is vital for enabling effective decision-making within the agricultural ecosystem. This study addresses the implementation of modern machine learning algorithms, including XGBoost, Automated Machine Learning (AutoML) utilising PyCaret, and Auto-ARIMA, for forecasting groundnut prices in Tamil Nadu. The research integrates key temporal information, such as day of the week, month, and lagged data, to boost the prediction performance. The findings illustrate the improved performance of the AutoML technique, with the Light Gradient Boosting Machine (LightGBM) model attaining the lowest Root Mean Squared Error (RMSE) of 516.511 and Mean Absolute Percentage Error (MAPE) of 5.1%. The feature significance analysis indicates the substantial effect of year and lagged factors on the XGBoost model's predictions. The study provides vital information for stakeholders in the agriculture industry, including farmers, traders, and policymakers, by delivering precise price estimates to promote informed decision-making.
A Simulation Approach to Investigate the Influence of the Steering Wheel Angle and Vehicle Speed on the Rollover of a 4-Axle Truck Vehicle During Turning on Wet Asphalt Road
Authors: Hung TA Tuan , Khanh DUONG Ngoc 
Published: April 2024

Abstract
The article aims to investigate the influence of vehicle speed and steering wheel angle on the rollover condition of a 4-axle truck vehicle. A 30-degree-of-freedom (DOF) dynamic model of a 4-axle truck is established using the Multi-body system method and the Newton-Euler equation system. The vehicle body is described with 6 DOF in its center. Additionally, 2 DOFs are used to describe the roll motion of the front and rear masses of the vehicle body, taking into account the influence of the torsional stiffness of the vehicle frame on vehicle dynamics. The Burckhardt tire model is used to calculate the interaction forces between tires and the road, using experimental coefficients corresponding to wet asphalt roads with a maximum adhesion coefficient of 0.8. The simulation uses MATLAB-Simulink, with a speed range of 5 to 65 km/h and a steering wheel rotation angle ranging from 25 degrees to 300 degrees. At 60km/h, the maximum lateral acceleration reached 4,503 m/sec2 when simulated with a steering wheel angle of 175 degrees. The results have determined the vehicle rollover region based on the signs of the load transfer ratio of the axle and the entire vehicle. Together with the results of lateral acceleration, yaw rate, and roll angle of the vehicle, this result can be used to propose dynamic thresholds for designing early warning systems and anti-rollover control systems for multi-axle truck vehicles.
“Pai Dulu, Yuk!”: Meninjau Inkulturasi Budaya Tionghoa—Jibbok, Maisong, Sangseng, Cengbeng dalam Kekristenan di Indonesia Kaitannya dengan Model Teologi Kontekstual Menurut Bevans dan Klasifikasi Terkait Christ and Culture Menurut Niebuhr
Authors: Chang Carmela , Listijabudi Daniel Kurniawan 
Published: April 2024

AbstractNow, Contextual Theology has become a “primary need” for humanity as an effort to understand their faith (in this case, the Christian faith) from the context of a particular era. Stephen B. Bevans, an American theologian, wrote models of contextual theology, one of which is the translation model. In addition, Niebuhr’s ideas of Christ and Culture have also contributed to religious and cultural practices in Indonesia. In reality, contextual theology is not that easy to apply in people’s daily lives. There are many differences, and if applied, the applications vary. A true story of a series of funerals in Chinese culture related to Jibbok, Maisong, Sangseng, Cengbeng, which are inculturated with the characteristics and liturgy of Christianity. What wasthe beginning of this? Why did the church end up “absorbing” such cultural practices? It is true that many Chinese crossbreed people in Indonesia embrace Christianity and thus implement Christian liturgy to Chinese culture which may or may not be in line with Christian values. However, which one comes first? Culture or religion?
Abstrak Kini, Teologi Kontekstual menjadi “kebutuhan primer” umat manusia sebagai upaya memahami iman mereka (dalam hal ini iman Kristen) dari konteks zaman tertentu. Stephen B. Bevans, seorang teolog Amerika, menuliskan model-model teologi kontekstual, salah satunya adalah model terjemahan. Selain itu, gagasan Niebuhr mengenai Christ and Culture juga turut memberi kontribusi terhadap praktik-praktik beragama dan berbudaya di Indonesia. Kenyataannya, berkontekstual tidak semudah itu diterapkan dalam kehidupan keseharian umat. Banyak perbedaan, dan jika diterapkan, penerapannya berbeda-beda. Sebuah kisah nyata dari rangkaian ritual kedukaan dalam budaya Tionghoa terkait Jibbok, Maisong, Sangseng, Cengbeng, yang terinkulturasi dengan karakteristik juga liturgi dalam Kekristenan. Apa yang menjadi awal terjadinya hal tersebut? Mengapa pada akhirnya gereja bisa “menyerap” praktik-praktik kebudayaan yangdemikian? Memang benar adanya bahwa banyak orang Tionghoa peranakan di Indonesia yang menganut agama Kristen sehingga menerapkan liturgi Kristen pada budaya Tionghoa yang mungkin bertentangan ataupun tidak sesuai dengan nilai-nilai Kekristenan. Kendati demikian, manakah yang lebih dulu hadir?Budaya atau agama?
Estudo epidemiológico de crianças e adolescentes acometidas por síndrome respiratória aguda grave na pandemia da covid-19
Authors: Vieira Claudia Cristina Augusto Rodrigues , Reis Adriana Teixeira , De Oliveira Larissa Paiva Alves , Ramos Gabriella Filippini Silva , Tavares Rosangela Cunha Machado , De Mendonça Hugo Santos Lemos 
Published: April 2024

Objetivo: Descrever o perfil epidemiológico dos vírus respiratórios e as características clínico-epidemiológicas das crianças e adolescentes hospitalizados com comprometimento respiratório agudo no período da pandemia da covid-19. Metodologia: Trata-se de um estudo transversal descritivo. A população do estudo são crianças e adolescentes de 0 a 18 anos hospitalizadas na unidade de terapia intensiva e enfermaria com comprometimento respiratório agudo, que apresente pelo menos 1 sintoma como febre, mesmo que referida, tosse, dor de garganta, dispneia, saturação de O2 < 95% ou desconforto respiratório, diarreia e vômito no período de março de 2020 a dezembro de 2021. Resultados: No período do estudo foram elegíveis 95 indivíduos, com predomínio do sexo masculino (50,5%) com comorbidades (58,2). O sintoma prevalente foi a dispneia (80%). A internação em unidade de terapia intensiva representou 53,6% e a necessidade de suporte ventilatório não invasivo 40%. O uso de oseltamivir representou 54,7% da amostra e o exame de imagem 28,4% evidenciando infiltrado pulmonar, 98,8% evoluíram com desfecho de cura. O vírus prevalente foi o vírus sincicial respiratório RSV. Conclusão: A importância do conhecimento da epidemiologia atual sobre vírus respiratórios nesta população contribui para uma prática clínica assertiva e direciona o cuidado ao público-alvo em questão, além de contribuir nas medidas de bloqueio e mitigação dos riscos de desfechos desfavoráveis.
Groundwater flow simulation for artificial recharge: a GIS, remote sensing, and MODFLOW integration
Authors: Nawale Sanchita , Mategaonkar Meenal 
Published: April 2024

ABSTRACT
Groundwater (GW) emerges as a sustainable resource to meet water demand, yet current GW reservoirs fall short of projected population needs. Artificial GW recharge, bolstered by Geographical Information System (GIS) and Remote Sensing (RS) technologies, stands out as a pivotal solution. Examining Aurangabad district in Maharashtra, India the study uncovers distinct challenges: Aurangabad faces escalating water demand due to population growth, leading to GW over exploitation. Leveraging hydrogeological parameters, rainfall analysis, and GW availability, the study proposes tailored GW recharge techniques. Utilizing MODFLOW simulation, the study explores diverse recharge rates and existing GW availability, showcasing promising results. Integration of stream augmentation, bladder pillow tank methods, and dug well recharge is examined via GIS and RS techniques. Simulation outcomes project significant GW level increases (11.55–23.70 m) with varying recharge rates, effectively meeting region-specific water demand projections. The findings underscore the imperative of sustainable water management practices and technological advancements in addressing water scarcity crises.
Geniposide Attenuates Oxygen-glucose Deprivation/Recovery-induced Retinal Ganglion Cell Injury via Akt/Nrf-2 Signaling Pathway
Authors: Hu Minghai , Chen Dekun , Wu Xiuyu , Ren Guo-Feng 
Published: April 2024

Background:
Glaucoma is an eye disease. Its pathological process involves
retinal ischemia-reperfusion (I/R), which causes irreversible blindness in patients. Geniposide
(Gen), a bioactive iridoid glycoside extracted from the fruit of gardenia, exhibits
many biological effects, such as anti-oxidative stress, anti-inflammation, anti-apoptosis,
anti-endoplasmic reticulum stress, and anti-thrombotic effects. However, its therapeutic
potential for the retinal I/R injury remains unclear. This study investigated the protective
effect of Gen against I/R injury by inhibiting abnormal reactive oxygen species (ROS)
and retinal neuron apoptosis.

background:
Glaucoma is a blinding eye disease, and retinal ischemia -reperfusion (I/R) is an important pathological process of glaucoma. Geniposide (Gen), as an important active natural component from Gardenia jasminoides Ellis fruit, which exerts multiple biological activities.

Methods:
We used oxygen-glucose deprivation/reoxygenation (OGD/R) to induce R28
cells to mimic the pathological process of I/R in glaucoma. We conducted CCK-8 analysis
and TUNEL staining to examine cell proliferation and apoptosis in glaucoma. Western
blotting was used to assay the expressions of apoptosis and Akt/Nrf-2 pathway-related
proteins.

Results:
The production of ROS was detected by using the corresponding kit. Cell viability
decreased, whereas TUNEL staining-positive cells and ROS production increased after
the OGD/R injury. The contents of cleaved caspase-3 and Bax/Bcl-2 increased after
the OGD/R injury. Treatment with 200 μM of Gen effectively improved the cell viability
and suppressed cell apoptosis and ROS production. In addition, Gen could significantly
promote the activation of the Akt/Nrf-2 signaling pathway in R28 cells, which was
blocked by the inhibition of Akt/Nrf-2. We in vivo verified the neuroprotective effect of
Gen by establishing an acute high intraocular pressure (aHIOP) model and obtained similar
results to those of the in vitro experimental results.

Conclusion:
Hence, it can be suggested that Gen provides neuroprotection against the
OGD/R-induced injury of R28 cells by activating the Akt/Nrf-2 signaling pathway,
which is beneficial for the clinical treatment of glaucoma.
1,3,4-Oxadiazole Scaffold in Antidiabetic Drug Discovery: An Overview
Authors: Gupta Ojasvi , Chawla Gita , Pradhan Tathagata 
Published: April 2024

:
Diabetes mellitus is one of the biggest challenges for the scientific community in the 21st
century. With the increasing number of cases of diabetes and drug-resistant diabetes, there is an urgent
need to develop new potent molecules capable of combating this cruel disease. Medicinal
chemistry concerns the discovery, development, identification, and interpretation of the mode of
action of biologically active compounds at the molecular level. Oxadiazole-based derivatives have
come up as a potential option for antidiabetic drug research. Oxadiazole is a five-membered heterocyclic
organic compound containing two nitrogen atoms and one oxygen atom in its ring. Oxadiazole
hybrids have shown the ability to improve glucose tolerance, enhance insulin sensitivity, and
reduce fasting blood glucose levels. The mechanisms underlying the antidiabetic effects of oxadiazole
involve the modulation of molecular targets such as peroxisome proliferator-activated receptor
gamma (PPARγ), α-glucosidase, α-amylase and GSK-3β which regulate glucose metabolism and
insulin secretion. The present review article describes the chemical structure and properties of
oxadiazoles and highlights the antidiabetic activity through action on different targets. The SAR for
the oxadiazole hybrids has been discussed in this article, which will pave the way for the design and
development of new 1,3,4-oxadiazole derivatives as promising antidiabetic agents in the future. We
expect that this article will provide comprehensive knowledge and current innovation on oxadiazole
derivatives with antidiabetic potential and will fulfil the needs of the scientific community in designing
and developing efficacious antidiabetic agents.
Revolutionizing Oral Cancer Treatment: Immunotherapeutic Approaches
Authors: Islam Md Moidul , Raikwar Sarjana 
Published: April 2024

Background:
Immunotherapy is a promising addition to the cancer treatment arsenal, with
the potential to be an effective adjuvant therapy. In the ever-changing landscape of cancer care, it
appears as a potential fourth pillar, supplementing surgery, chemotherapy, and radiation. The key to
effective immunotherapy is cautious patient selection, which is based on a thorough study of the
unique immune makeup of each patient.

Aim:
This review article aims to provide a comprehensive understanding of the fundamental principles
of tumor immunity and immunotherapy, with a specific focus on oral squamous cell carcinoma.

Methods:
The review involved a thorough investigation of scientific databases and relevant publications,
including studies conducted up to the present date obtained from PubMed, Science Direct, and
Google Scholar Key. The selected studies underwent careful evaluation for methodological rigor and
the significance of their findings.

Results:
Checkpoint inhibitors, targeted monoclonal antibodies, adoptive cell transfer, cancer vaccines,
biomarkers and prediction tools, and cytokine immunotherapy are all promising treatments for
oral cancer.

Conclusion:
In recent decades, there has been a substantial increase in interest and study in cancer
immunotherapy, indicating a turning point in our approach to cancer treatment. While significant
progress has been made, major hurdles remain across a range of cancers.
Sintering Driven Void Formation in PS@WO3 Core-Shell Composites: A Photodegradation Enhancement Strategy
Authors: Yeh Min Yen , You Ruei Ying , Cheng Po Wen , Hwang Shih-Syuan , Hu Gui-Cheng , Chang Shun Hsyung 
Published: April 2024

Background:
Polystyrene nanospheres are used as a substrate for the hydrothermal coating
of tungsten trioxide (WO3) to form a core-shell composite of PS@WO3. The core-shell structure
is used for the next sintering step. This produces porous WO3. The focus of this study is on the role
of porous WO3 in enhancing photocatalytic performance.

Methods:
The hydrothermal method was employed for coating, and the surface morphology, as well
as the structural properties of WO3-coated PS spheres, were systematically investigated using SEM
and XRD analyses. Additionally, the sintering process was introduced to enhance the material by
inducing rupture in the PS sphere core, creating voids that significantly increased the material's surface
area.

Results:
The evaluation of the effect of sintering temperature on photodegradation efficiency highlighted
the crucial role of sintering temperature. Un-sintered and 300°C sintered WO3, both having a
hexagonal crystalline structure, exhibited superior degradation efficiencies compared to samples
sintered at higher temperatures (400°C and 500°C). In particular, the 300°C sintered WO3 outperformed
its un-sintered counterpart despite identical crystalline structures. The performance of the
PS@WO3 composite was assessed to determine the enhanced role of porous WO3. The porous WO3
obtained, in particular by the sintering of the core-shell PS@WO3 composites at 300°C, showed a
remarkable improvement in the degradation efficiency. These composite demonstrated over 95%
efficiency within 10 minutes and achieved near complete (100%) degradation for a further 10
minutes, surpassing the performance of pure WO3. It is important to clarify that while the final product
was predominantly WO3 after the sintering process, the inclusion of PS served a critical purpose
in creating voids during sintering. The PS@WO3 composite structure used as a resource for the preparation
of porous WO3, even with a potentially reduced PS composition, has been found to play a
significant role in influencing the surface area of the material, and consequently the photocatalytic
performance.

Conclusion:
The study has highlighted the importance of crystalline structure and sintering conditions
in optimizing the efficiency of photocatalytic materials. The porous WO3 obtained, in particular
by the sintering of the core-shell PS@WO3 composites at 300°C, showed promising potential for
applications under UV and visible LED light irradiation. These results provide valuable insights for
the development of advanced photocatalytic materials with improved performance, highlighting
WO3 as the key contributor to the observed improvements.