bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between salivary cortisol levels with risk of behavioral-psychosocial-emotional disorders in adolescents aged 12-16 years
Authors: Sanjaya Ayling 
Published: May 2024

Introduction: Adolescents suffer from various forms of psychosocial, behavioral, mental and emotional problems. The relationship between salivary cortisol levels and the risk of behavioral-psychosocial-emotional disorders in adolescents is still controversial. To analyze the relationship between salivary cortisol levels and the risk of behavioral-psychosocial-emotional disorders in adolescents aged 12-16 years using PSC-17.
Methods: An observational analysis with a cross-sectional research design and simple random sampling was conducted from November 2022 - March 2023. Adolescents aged 12-16 years filled out biodata, characteristics and PSC-17 questionnaires. Salivary cortisol levels were measured by the Enzyme-linked immunosorbent assay method. Data analysis with univariate and multivariate tests.
Results: Of 170 adolescents, 53 (31.2%) were at risk of behavioral-psychosocial-emotional disorders with PSC-17 total score ≥15, consisting of risk of internalizing disorders at 73 (42.9%) adolescents, risk of externalizing disorders at 14 ( 8.2%), risk of attention disorder at 23 (13.5%) adolescents. The majority of adolescents who have normal salivary cortisol levels are 117 (68.8%) adolescents, and salivary cortisol levels are abnormal (high) in 53 (31.2%) adolescents. Salivary cortisol levels were associated with adolescents' risk of behavioral-psychosocial-emotional disorders (p<0.001).
Conclusion: Salivary cortisol levels are associated with the risk of behavioral-psychosocial-emotional disorders in adolescents. Likewise, salivary cortisol levels are related to the risk of internalizing disorders, the risk of externalizing disorders, and the risk of attention disorders in adolescents.
A case report of Apert syndrome
Authors: Cahyana Nugraha Wahyu 
Published: May 2024

Link of Video Abstract: https://youtu.be/ahjJloTwZQE

Introduction: Apert syndrome (AS) is a rare type 1 acrocephalosyndactyly syndrome, characterized by craniosynostosis, severe syndactyly of the hands and feet, and dysmorphic facial features. It exhibits autosomal dominant inheritance assigned to mutations in the fibroblast growth factor receptor gene.
Case Illustration: We presently describe the case of a 14 years old male patient with acrocephaly, prominent forehead, ocular hypertelorism, proptosis, short and broad nose, pseudoprognathism, crowding of teeth and ectopia, maxillary hypoplasia, low hairline, webbed neck, pectus excavatum, and severe bilateral syndactyly of hands and feet. The examination revealed apical cranium, occipital flattening, enlargement and hypoplasia of the premaxillary opening, crowding, ectopic teeth, tapering of the mandibular apex, and pseudognathia.
Conclusion: We reported a 14 years old male patient with AS with craniosynostosis and acrocephalosyndactyly. The characteristics of clinical manifestation of AS should be aware by physicians to be able to diagnose the disease.
Obstetrical ballooning and avulsion of levator ani muscle after vaginal delivery: a literature review
Authors: Rahman Muhammad Nurhadi , Sukarsa Mochamad Rizkar Arev , Rinaldi Andi , Achmad Eppy Darmadi , Sasotya Raden Mas Sonny , Armawan Edwin , Yanuaristi Herdifitrianne Saintissa , Putri Azura Nabila 
Published: May 2024

Link of Video Abstract: https://youtu.be/TWDe9uP4QX8

The levator ani muscle (LAM) is thought to be of central importance concerning pelvic organ support. 10-30% of women experience overstretched or 'ballooning' of the levator hiatus, sometimes followed by detachment or 'avulsion' of the muscle from its insertion. Both ballooning and avulsion of the LAM can occur by itself or co-exist at the same time. This literature review was conducted on multiple databases from previous studies, to help clinicians better understand the ballooning and avulsion phenomenon, thus making early diagnosis possible for earlier prolapse prevention for the patients. LAM avulsion can be diagnosed clinically using digital palpation or using imaging modalities such as ultrasound and magnetic resonance imaging (MRI). During maximal contraction (or at rest) using ultrasound, levator avulsion is indicated through a levator-urethra gap (LUG) diameter > 2.5 cm. MRI is considered highly sensitive, but it requires a higher cost and an experienced radiologist. Hiatal ballooning can be diagnosed by clinical examination based on the sum of Genital hiatus and Perineal body (Gh+Pb) and imaging with 2D, 3D, or 4D ultrasound during the Valsava maneuver. Ballooning is diagnosed clinically if Gh+Pb > 7 cm, by 2D imaging of levator hiatal anteroposterior (LHAP) diameter ≥ 6 cm, and by 3D/4D imaging of the hiatal area ≥ 25 cm2. Physiotherapeutic treatment and pelvic floor muscle (PFM) exercises can be used to treat ballooning and LAM avulsion to avoid urogynecological sequelae. There is some evidence to prevent this condition, including vitamin D consumption, epidural analgesia, kegel exercise, and vaginal dilator. PFM strength, posterior vaginal wall support, and ultrasound evidence of LAM tear can be used as potential indicators to predict pelvic floor injury. Since ballooning and avulsion of the LAM have lifelong morbidity and are not often identified early by clinicians, further research is still needed.
The relationship between parental risk factors with degree of severity in myopia
Authors: Marisa Surya Airlangga  , Deneska Ria Sandy , Rozalina Loebis  , Reni Prastyani  
Published: May 2024

Link of Video Abstract: https://youtu.be/5LTsY60dY0s

Background: Myopia is one of the numerous visual problems that continue to increase in incidence throughout the world. Various genetic and environmental factors are thought to influence the onset of myopia. Myopia is known to have a significant impact on the economy, vision problems, and a decrease in quality of life so that it needs serious attention. This study aims to explore the relationship between parental risk factors with degree severity of myopia.
Methods: This study is an analytic observational study research design. The population of this study are patients diagnosed with myopia in the Ophthalmology Outpatient Clinic of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Patients who met the inclusion and exclusion criteria were included as samples. Data are gathered through medical records and by questionnaire, this includes age and spherical equivalent (SE) in right eye or left eye. Degree of severity was classified based on SE. Myopia’s degree of severity and parental history are then analyzed to determine the relationship.
Results: A total 72 patients were included in this study. The majority of participants have a familial history of parental myopia. The degree of severity with the highest frequency is low myopia. The results of statistical tests showed that there was no relationship between history of parental myopia and the severity of myopia in the right eye (RE) (p-value = 0.712) and the severity of myopia in the left eye (LE) (p-value = 0.565).
Conclusion: There was no relationship between the history of parental myopia and the severity of myopia.
A double-blind, randomized controlled trial of hydroxychloroquine for cognitive dysfunction and antibody biomarkers in systemic lupus erythematosus patients
Authors: Suntoko Bantar , Suharyo Hadisaputro  , Handono Kalim  , Suyanto Hadi  , Fenda Aditia  
Published: May 2024

Link of Video Abstract: https://youtu.be/51QxGpETzG0

Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that leads to persistent inflammation, resulting in organ tissue damage. Cognitive dysfunction is one of the symptoms often found in NPSLE, and hydroxychloroquine is recommended for all levels of SLE from mild to severe. However, studies on the efficacy of hydroxychloroquine for cognitive dysfunction have not been studied. Therefore, this study aimed to evaluate the effect of hydroxychloroquine administration on antibody levels and cognitive function in lupus patients with cognitive dysfunction.
Methods: A Randomized Controlled Trial (RCT) was conducted in patients with SLE who experienced cognitive dysfunction. The treatment group consisted of 20 subjects subjected to standard therapy along with a daily dosage of hydroxychloroquine (200 mg/day) for 8 weeks. Furthermore, the control group comprised 20 subjects who only received standard therapy. The primary outcome of this trial focused on the evaluation of MoCA-INA and sub-MoCA-INA scores, while the secondary outcome included the measurement of anti-NMDA, anti-β2-glycoprotein-1, anticardiolipin IgM and IgG antibodies, as well as lupus anticoagulant levels. Data analysis for unpaired variables used the independent t-test or the Mann-Whitney test.
Results: There was a relationship between giving hydroxychloroquine administration to increasing the sub-MOCA-INA attention score (p<0.05). However, there was no relationship between giving hydroxychloroquine to increasing MoCA-INA scores and decreasing biomarker levels of anti-NMDA, anti-β2-glycoprotein-1, IgM-IgG anticardiolipin, and lupus anticoagulant (p>0.05)
Conclusion: Administration of hydroxychloroquine only affected attentional MoCA-INA sub-scores but did not affect other MoCA-INA sub-scores, overall MoCA-INA scores, and antibody levels.
The association of Hypoxia-Inducible Factor-2α (HIF-2α) overexpression score with Germinal Center B-Cell Like (GCB) and Non-Germinal Center B-Cell Like (Non-GCB) subtypes of Diffuse Large B-cell Lymphoma (DLBCL)
Authors: Adhi Pangarsa Eko , Ewika Ardini Desta Nur , Rizky Daniel , Tandarto Kevin , Istiadi Hermawan , Puspasari Dik , Setiawan Budi , Santosa Damai , Hertanto Wahyu Subagio  , Tri Indah Winarni  , Haryana Sofia Mubarika , Suharti Catharina 
Published: May 2024

Link of Video Abstract: https://www.youtube.com/watch?v=KF58IGGdWmc

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma. It is classified into homogeneous subtypes, namely Germinal Center B-Cell Like (GCB) and Non-Germinal Center B-Cell Like (GCB), with the latter associated with worse survival outcomes. Increased expression of Hypoxia-Inducible Factor-2α (HIF-2α) is often observed in DLBCL and has been correlated with enhanced angiogenesis, suggesting its potential as a prognostic factor in managing DLBCL. The study evaluates the association between HIF-2α overexpression and the GCB and non-GCB subtypes of DLBCL.
Methods: This cross-sectional study utilized samples from DLBCL patients at Dr. Kariadi Semarang Hospital between January and December 2021. Immunohistochemistry was performed on the samples to determine the DLBCL subtypes and assess the presence of HIF-2α. HIF-2α was evaluated by immunohistochemistry based on its distribution and intensity. The Kruskal-Wallis test was used to find the association between HIF-2α expression and the GCB and non-GCB subtypes of DLBCL. Furthermore, Spearman's rank correlation test explored the correlation between all numeric variables.
Results: A total of 30 subjects were included in this study, with 7 samples of GCB subtype (23.3%) and 23 samples of non-GCB subtype (76.6%). Kruskal-Wallis test showed no association between HIF-2α expression and the subtypes of DLBCL (p=0.812). Spearman's rho correlation test indicated no correlation between HIF-2α overexpression score with NCCN IPI score in GCB (r=0.219; p=0.637) and non-GCB (r=-0.194; p=0.386).
Conclusion: There was no association between HIF-2α expression and GCB and non-GCB subtypes of DLBCL. Additionally, no correlation was found between HIF-2α overexpression and NCCN IPI score.
The application of enhanced recovery after surgery (ERAS) protocol in radical cystectomy and urinary diversion using bowel segment reduces the length of stay: A multicenter comparative study in Indonesia
Authors: Hamid Agus Rizal Ardy Hariandy , Soeroto Adhitama Alam , Hendri Ahmad Zulfan , Pramod Sawkar Vijay , Prapiska Faurisky Febrian , Aditianingsih Dita , Ratna Nurul , Mochtar Chaidir Arif , Umbas Rainy 
Published: May 2024

Link of Video Abstract: https://youtu.be/GvdRCXyJmuk

Introduction: Radical cystectomy is one of the most invasive urological procedures, with high difficulty and various complications. The Enhanced Recovery After Surgery (ERAS) protocol was created to improve patient outcomes after such surgery, including radical cystectomy. This study aims to evaluate the application of ERAS on radical cystectomy in Indonesia.
Methods: This was a multicenter study (Jakarta, Yogyakarta, Bandung, and Medan) from July 2016 to April 2021. This study compared the postoperative length of stay, diet intake, bowel movement, and mobilization pattern of the subject receiving ERAS protocol with the non-ERAS subject. Curtailed, fast preoperative carbohydrate loading was administered to patients. There was no mechanical bowel preparation except one day before in selected cases. Postoperative patterns after surgery and the length of stay were analyzed.
Results: We collected 128 subjects in this study, with 74 (60 %) subjects enrolled with ERAS protocol and 54 (40 %) with non-ERAS. There were statistically significant differences in length of stay with a median of 11 days vs. 16 (p: 0.001), intensive care unit admission duration with a median of 2 days vs. 3 (p: 0.004) and time to sit after radical cystectomy with a mean of 2.14 days vs 2.89 (p-: 0.004) in subject with ERAS protocol compared to non-ERAS protocol.
Conclusion: This multicenter study found that ERAS was demonstrated to be efficacious in decreasing the duration of hospital stay, the duration of intensive care unit admission, and the time for the subject to sit after the radical cystectomy.
Surgical outcomes among spinal tuberculosis patients: a study from a provincial reference hospital in Indonesia
Authors: Azharuddin  , Ramadhani Adinda Zahra Ayufi , Sary Nirwana Lazuardi , Rahman Safrizal , Azhary Mulkan 
Published: May 2024

Link of Video Abstract: https://youtu.be/_5_xwPSsNFc

Introduction: Spinal tuberculosis is one of the most common forms of extrapulmonary tuberculosis, which can cause a significant loss of functional ability and decrease in quality of life. Surgery has become an integral component in the current management of spinal tuberculosis that could improve neurological deficits and functional status, yet it may expose patients to surgical site infection (SSI). The aim of the study was to observe the incidence of SSI and improved neurological deficits and functional status post-surgery among patients with spinal tuberculosis.
Methods: The medical records (n=91) were collected retrospectively from patients admitted between January 2019 and June 2022. Characteristic data collected in this study included age, gender, education, occupation, domicile, history of smoking, history of pulmonary tuberculosis, presence of comorbidity. Patients were contacted for history of SSI, postoperative neurological deficits, and functional status assessments through interview using Frankel Grade and Barthel Index instruments, respectively.
Results: The results revealed that only two percent of the total patients developed SSI. Number of patients with Frankel Grade E increased from 0 to 72 (79.1%), and only three patients (3.3%) had persistent Frankel Grade B after the surgery. Sixty-eight patients (74.7%) who underwent the surgery enjoyed independent state of functional status, whereas prior to the surgery, the number was smaller (n=18, 19.8%). The favorable surgical outcomes were found predominantly in female patients (83.9%), 17–25-year-old patients (93.3%), and those having no history of smoking (82.5%–84.2%) and comorbid disease (81.9%–83.3%). The recovery was mostly observed 1–2 years post-surgery (87.2%).
Conclusion: Spinal surgery for patients with spinal tuberculosis improves neurological deficits and functional status. The risk of contracting SSI after the surgery is considered to be low.
Supplementation of Moringa (Moringa oleifera) leaf capsules on hemoglobin levels in women of reproductive age with iron deficiency anemia in Malaka regency, Nusa Tenggara Timur, Indonesia
Authors: Siagian Carmen , Djogo Maria Fransisca , Nahak Maria Martina , Tedjasulaksana Regina , Manek Alfridus Emanuel , Sormin Elferida , Levina Augusta Geraldine Pieter  
Published: May 2024

Link of Video Abstract: https://youtu.be/DjGx56j9LiU

Introduction: Women of reproductive age with anemia are recommended to take iron supplements and increase their intake of iron-rich food. Moringa (Moringa oleifera) leaf is a potential plant containing high iron, which is simple to find in Indonesia.
Aims: to determine the effectiveness of Moringa leaves supplementation in women of pro age.
Methods: This type of research is an experiment with experimental research with pre-post test control group design. The sample was 119 subjects collected using purposive sampling according to the inclusion criteria. The study subjects were divided into 3 treatment groups: supplementation of Ferrous sulfate tablets 30 mg per day (Group P0); 3000 mg Moringa leaf capsules three times a day (3 x 1000 mg) (Group P1); and Moringa leaf capsules at a dose of 3000 mg three times a day (3 x 1000 mg) plus 30 mg ferrous sulfate tablets once daily (Group P2) for 60 days, then hemoglobin (Hb) levels were re-evaluated.
Result: The Friedman test showed a mean Hb difference between the three measurement groups, which was statistically significant with p <0.05. The treatment group with P2 had the highest value of 4.74, followed by P1 and P0 of 4.71 and 4.65.
Conclusion: Supplementation of Moringa leaf capsules at a dose of 3000 mg for 60 days may increase Hb levels in women of reproductive age with iron deficiency anemia.
The relationship between traditional postnatal care (TPC) and sociodemographic of postnatal mothers in Kota Kinabalu, Sabah, Malaysia
Authors: Sator Patricia , Nicholas Tze Ping Pang  , Rekaya Anak Vincent Balang  , Rosalia Saimon  , Mohammad Saffree Bin Jeffree  , Norkiah Arsat  
Published: May 2024

Link of Video Abstract: https://youtu.be/Ethmg0srBhU

Background: Traditional Postnatal Care (TPC) is derived from traditional medicines as health practices. The approaches of knowledge and beliefs incorporating plant and manual techniques are applied singularly or in combination to prevent illnesses and maintain well-being. TPC is used widely among the postnatal mother as a self-care for the healing process, both physically and mentally. As part of the nursing management in a community health setting, understanding the different health and wellness approaches and their benefits is part of the early knowledge and skills when delivering care to postnatal mothers. This study aimed to assess the relationship between TPC and sociodemographic data of postnatal mothers in selected study settings to understand more about the types of common TPC practiced within the study setting.
Methods: Participants were among the postnatal mothers within one week after delivery and selected purposely based on inclusion criteria. A cross-sectional survey from November 2021 to February 2022 with 178 postnatal mothers completed the distributed questionnaires. The researcher used SPSS version 28.0 to analyse the data.
Results: The result showed that the educational background (p=0.001, p<0.05) and household income per month (p=0.001, p<0.05) demonstrated a significant effect concerning postnatal mothers practising and non-practising TPC.
Conclusion: This study identified the significant variables of sociodemographic, namely household income and education level. This study’s result is the starting point for the researcher to begin a broader analysis of this title.
Clinical epidemiology pattern of orthopedic trauma during the COVID-19 pandemic: A multicenter study (Dr. Hasan Sadikin General Hospital and Ulin General Hospital)
Authors: Rahim Agus Hadian , Hidajat Nucki Nursjamsi , Ismiarto Yoyos Dias , Mulyadi Dicky , Arsa Widya , Ramdhan Ahmad , Utoyo Ghuna Arioharjo , Irawan Muhamad Naseh Sajadi Budi , Primadhi Raden Andri , Herman Herry , Alpharian Gibran Tristan , Prasetia Renaldi , Hadar Abdul Kadir , Malik Realita , Noor Zairin , Zulkarnaen Izaak , Siagian Andreas , Putra Husna Dharma , Danayanti Essy Dwi , Kesuma Wongso , Iqbal Muhammad , Cristian Setiadi  
Published: May 2024

Link of Video Abstract: https://youtu.be/JRX2wJWFCKs

Introduction: COVID-19 has had profound implications on global healthcare systems, and this pandemic management has led to a significant change in orthopedic surgical activity. We aimed to evaluate the types and incidence of fractures treated during the pandemic to provide insight into the situations for which orthopedic trauma surgeons should be prepared in unusual circumstances that may arise in the future.
Methods: Descriptive observational cross-sectional study from Dr. Hasan Sadikin General Hospital and Ulin General Hospital was conducted from electronic medical records between January 2018 and December 2022. Analysis was performed using SPSS version 26 on descriptive analysis using mean, frequency, percentage, and standard deviation.
Results: 2890 patients were enrolled for the current cohort, from 2018 until 2022, with predominantly male (n = 2117). Even though, an increase in overall admission from 2018 (n = 631) to 2019 (n = 784), a decrease after that occurred during the COVID-19 pandemic, which is from 2020, 2021, and 2022 (n = 652, 500, and 323, respectively)
Conclusion: Knowing the number of fractures can be a tool to evaluate the types and incidence of fractures treated during the pandemic to provide insight into the situations for which orthopedic trauma surgeons should be prepared in unusual circumstances that may arise in the future.
Characterization of ultraviolet B light emitting diodes (UVB LED) irradiation device for Wistar rats as an experimental animal model
Authors: Diah  , Prahasanti Chiquita , Rahayu Retno Puji , Wijayanto Vani Rachmad 
Published: May 2024

Link of Video Abstract: https://youtu.be/-l5AY96hUI8

Background: Light emitting diodes (LED) lamps are used widely in daily because of their many benefits, including their low cost, extended lifespan, low energy consumption, and low environmental impact. The use of LEDs, especially ultraviolet B LED (UVB LEDs) is quite extensive and has been developed for the treatment of skin diseases, irradiating pet reptiles, and conducting research on experimental animals. The use of light for therapy must be done carefully so that unwanted side effects do not occur because light also harms tissue. The purpose of this characterization is to determine the stability of temperature and irradiation of the device we make and to determine the duration of light exposure based on the characterization.
Methods: The irradiation device use UVB LEDs with a wavelength of 305-310 nm. The characterization carried out included temperature stability and irradiation stability, with observations every 30 minutes for 10 hours and no replication. Statistical analysis using the Kolmogorov-Smirnov (Asymptotic Approximation) testing technique. The test criteria state that if the probability value > level of significance (alpha (α) = 5%).
Results: The characterization results from 10 hours of observation with sampling data taken every 30 minutes showed stable LED temperature and room temperature while unstable cage temperature and irradiance.
Conclusion: This device can be considered to use in Wistar rat’ experimental studies using UVB and perhaps developed further. The duration of exposure can be adjusted according to the distance of the object and the dose required.