bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Regulatory Strategies Reduce Gambling Spend and Harm in a Randomised Controlled Trial of Electronic Gaming Machine Players
Authors: Hing Nerilee , Browne Matthew , Tulloch Catherine , Russell Alex M. T. , Rockloff Matthew 
Published: May 2024

AbstractResearch provides insights into the self-regulatory strategies (SRSs) gamblers use, but evidence supporting their efficacy is weak. Study 1 aimed to identify a set of SRSs that best predict less harmful gambling amongst electronic gaming machine (EGM) players who are most vulnerable to EGM-related harm. Study 2 aimed to test their efficacy as a brief intervention in a randomised controlled trial. Study 1 surveyed 2032 EGM players and compared SRS-use amongst harmed and less-harmed players after propensity matching and weighting. Study 2 delivered 13 efficacious SRSs identified in study 1 as a brief intervention in a three-wave RCT and assessed their effect on time and money spent on EGMs and EGM-related harm. In study 1, the individual use of 17 SRSs and the total count of these SRSs used were associated with lower EGM-related harm. In study 2, assignment to three SRSs resulted in reduced EGM spend, with no detectable effects for 10 other SRSs. More frequent reported use of one of the same SRSs and an additional two SRSs also resulted in reduced EGM spend and/or reduced EGM-related harm. The results provide new evidence about the efficacy of certain SRSs to result in beneficial gambling outcomes: setting aside a fixed amount to spend, taking regular breaks, keeping leisure time busy with other activities, not gambling due to boredom, and keeping a household budget. These SRSs could be communicated as actionable strategies people can use to help reduce gambling harm.
Long/Post-COVID-Syndrom
Authors: Thurner Carolin , Stengel Andreas 
Published: May 2024

ZusammenfassungIn diesem Artikel der Zeitschrift für Psychodrama und Soziometrie wird die Behandlung von Patient*innen mit Long/Post-COVID-Syndrom diskutiert. Dabei ist das Krankheitsbild geprägt von multiplen, diffusen und mit aktuellen Diagnosemethoden meist somatisch nicht erklärbaren Symptomen. In diesem Artikel schlagen wir die Einordnung als Somatic Symptom Disorder und eine interdisziplinäre Behandlung auf Basis des biopsychosozialen Modells vor.
The Effects of FABP4 on Cardiovascular Disease in the Aging Population
Authors: van der Ark-Vonk Ellen M. , Puijk Mike V. , Pasterkamp Gerard , van der Laan Sander W. 
Published: May 2024

Abstract
Purpose of Review
Fatty acid-binding protein 4 (FABP4) plays a role in lipid metabolism and cardiovascular health. In this paper, we cover FABP4 biology, its implications in atherosclerosis from observational studies, genetic factors affecting FABP4 serum levels, and ongoing drug development to target FABP4 and offer insights into future FABP4 research.

Recent Findings
FABP4 impacts cells through JAK2/STAT2 and c-kit pathways, increasing inflammatory and adhesion-related proteins. In addition, FABP4 induces angiogenesis and vascular smooth muscle cell proliferation and migration. FABP4 is established as a reliable predictive biomarker for cardiovascular disease in specific at-risk groups. Genetic studies robustly link PPARG and FABP4 variants to FABP4 serum levels. Considering the potential effects on atherosclerotic lesion development, drug discovery programs have been initiated in search for potent inhibitors of FABP4.

Summary
Elevated FABP4 levels indicate an increased cardiovascular risk and is causally related to acceleration of atherosclerotic disease, However, clinical trials for FABP4 inhibition are lacking, possibly due to concerns about available compounds’ side effects. Further research on FABP4 genetics and its putative causal role in cardiovascular disease is needed, particularly in aging subgroups.
Exploring the Full Potential of Radiofrequency Technology: A Practical Guide to Advanced Radiofrequency Ablation for Complex Ventricular Arrhythmias
Authors: Tonko J. B. , Lambiase P. 
Published: May 2024

Abstract
Purpose of Review
Percutaneous radiofrequency (RF) catheter ablation is an established strategy to prevent ventricular tachycardia (VT) recurrence and ICD shocks. Yet delivery of durable lesion sets by means of traditional unipolar radiofrequency ablation remains challenging, and left ventricular transmurality is rarely achieved. Failure to ablate and eliminate functionally relevant areas is particularly common in deep intramyocardial substrates, e.g. septal VT and cardiomyopathies. Here, we aim to give a practical-orientated overview of advanced and emerging RF ablation technologies to target these complex VT substrates. We summarize recent evidence in support of these technologies and share experiences from a tertiary VT centre to highlight important “hands-on” considerations for operators new to advanced RF ablation strategies.

Recent Findings
A number of innovative and modified radiofrequency ablation approaches have been proposed to increase energy delivery to the myocardium and maximize RF lesion dimensions and depth. These include measures of impedance modulation, combinations of simultaneous unipolar ablations or true bipolar ablation, intramyocardial RF delivery via wires or extendable RF needles and investigational linear or spherical catheter designs. Recent new clinical evidence for the efficacy and safety of these investigational technologies and strategies merits a re-evaluation of their role and clinic application for percutaneous VT ablations.

Summary
Complexity of substrates targeted with percutaneous VT ablation is increasing and requires detailed preprocedural imaging to characterize the substrate to inform the procedural approach and selection of ablation technology. Depending on local experience, options for additional and/or complementary interventional treatments should be considered upfront in challenging substrates to improve the success rates of index procedures. Advanced RF technologies available for clinical VT ablations include impedance modulation via hypotonic irrigation or additional dispersive patches and simultaneous unipolar as well as true bipolar ablation. Promising investigational RF technologies involve an extendable needle RF catheter, intramyocardial RF delivery over intentionally perforated wires as well as a variety of innovative ablation catheter designs including multipolar linear, spherical and partially insulated ablation catheters.
Three Sociologists as National Leaders: Fernando Henrique Cardoso, Jože Pučnik and Bernardo Arévalo
Authors: Goertzel Ted 
Published: May 2024

AbstractFernando Henrique Cardoso of Brazil and Bernardo Arévalo of Guatemala are PhD sociologists who served as presidents of their countries. Jože Pučnik of Slovenia, also a PhD sociologist, was a leading but defeated candidate in his country’s first post-communist presidential election. This paper explores the relationship between their sociological work and their political careers. Cardoso’s work was interdisciplinary and focused on historical conjunctures. He was very widely cited in scholarly publications. Pučnik was concerned with overcoming fundamentalist megaliths and uniting theory and practice. He had difficulty communicating the relationship between his sociology and his political leadership. Arévalo wrote a dissertation in the historical sociology of Guatemalan militarism, and also pursued an applied sociological career in conflict resolution. Sociological leadership may be enhanced by using middle-range theories tuned to current situations, especially at times of crisis, and by advocating timely and feasible solutions.
Beyond borders: exploring the impact of Italian migration control policies on Mediterranean smuggling dynamics and migrant journeys
Authors: Punzo Valentina , Scaglione Attilio 
Published: May 2024

AbstractIn recent years, the Mediterranean crossings have reconfirmed their status as the most perilous routes for migrants attempting to reach European shores, with a significantly high number of deaths. In response, the Italian government has implemented various strategies aimed at reducing the number of landings and controlling irregular migration. This research evaluates the impact of these measures on the dynamics of migrant smuggling, both qualitatively and quantitatively. It examines the effectiveness of these measures and their influence on the adaptation of routes, methods, and organization of criminal groups involved in smuggling. The study emphasizes that while the measures to curb irregular immigration have had a limited direct impact on overall migratory flows and primary routes, they have indirectly influenced smugglers’ strategies. The study is grounded in empirical data sourced from interviews with expert witnesses and judicial investigations conducted by Italian prosecutors, with a comprehensive analysis of quantitative data. The findings aim to contribute to a deeper understanding of the multifaceted nature of irregular migration in the Mediterranean and the impacts of policy interventions.
Broken Ray Transform for Twisted Geodesics on Surfaces with a Reflecting Obstacle
Authors: Jathar Shubham R. , Kar Manas , Railo Jesse 
Published: May 2024

AbstractWe prove a uniqueness result for the broken ray transform acting on the sums of functions and 1-forms on surfaces in the presence of an external force and a reflecting obstacle. We assume that the considered twisted geodesic flows have nonpositive curvature. The broken rays are generated from the twisted geodesic flows by the law of reflection on the boundary of a suitably convex obstacle. Our work generalizes recent results for the broken geodesic ray transform on surfaces to more general families of curves including the magnetic flows and Gaussian thermostats.
Enhanced photoluminescence of a microporous quantum dot color conversion layer by inkjet printing
Authors: Chen Junchi , Jin Qihao , Donie Yidenekachew. J. , Perales Orlando. T. , Busko Dmitry , Richards Bryce S. , Lemmer Uli 
Published: May 2024

AbstractOwing to their high color purity, tunable bandgap, and high efficiency, quantum dots (QDs) have gained significant attention as color conversion materials for high-end display applications. Moreover, inkjet-printed QD pixels show great potential for realizing full-color mini/micro-light emitting diode (micro-LED)-based displays. As a color conversion layer, the photoluminescence intensity of QDs is limited by the insufficient absorptance of the excitation light due to the lack of scattering. Conventional scatterers, such as titanium dioxide microparticles, have been applied after additional surface engineering for sufficient dispersity to prevent nozzle clogging in inkjet printing process. In our work, as an alternative approach, we use inkjet printing for depositing a phase separating polymer ink based on polystyrene (PS) and polyethylene glycol (PEG). QD/polymer composite pixels with scattering micropores are realized. The morphology of the micropores can be tailored by the weight ratio between PS and PEG which enables the manipulation of scattering capability. With the presence of the microporous structure, the photoluminescence intensity of the QD film is enhanced by 110% in drop-cast films and by 35.3% in inkjet-printed QD pixel arrays compared to the reference samples.
Transcriptome analysis revealed SMURF2 as a prognostic biomarker for oral cancer
Authors: Deng Lu , Wu Zhihong , Sun Chuanxi , Liu Zhe 
Published: May 2024

Abstract

Background
The activation of TGF-β pathway can facilitate tumorigenesis. Understanding the TGF-related genes (TRGs) in oral cancer and determining their prognostic value is of utmost importance.

Methods
The TRGs were selected to develop a prognostic model based on lasso regression. Oral cancer patients were classified into high-risk and low-risk groups based on the risk model. Subsequently, multivariate COX regression was employed to identify the prognostic marker. Additionally, the expression of SMURF2 was validated using quantitative real-time polymerase chain reaction (qRT-PCR) and the Human Protein Atlas (HPA) database. To investigate the relationship between SMURF2 expression and immune cell infiltrations, we conducted single-sample Gene Set Enrichment Analysis (ssGSEA) analyses.

Results
We identified 16 differentially expressed TRGs in oral cancer, all of which showed upregulation. From these, we selected eight TRGs as prognostic signatures. Furthermore, the high-risk group demonstrated lower infiltration levels of immune cells, immune score, and higher tumor purity. Interestingly, we also found that SMURF2 serves as an independent prognostic biomarker. SMURF2 was upregulated in oral cancer, as confirmed by public databases and qRT-PCR analysis. Importantly, our results indicate a close association between SMURF2 expression and the immune microenvironment.

Conclusion
The 8-TRG signature prognosis model that we constructed has the ability to predict the survival rate and immune activity of oral cancer patients. SMURF2 could be effective in recognizing prognosis and evaluating immune efficacy for oral cancer.
W-Leg Jumping Robot: Mechanical Design, Dynamical Analysis and Simulation of Jumping Dual Wheel-Leg Hybrid Robot
Authors: Tatar Ahmet Burak 
Published: May 2024

AbstractThis study primarily focuses on design, mathematically model and simulate a novel two wheel-legged hybrid robot called W-Leg Jumping robot, which has a unique ability to overcome step-like obstacles efficiently. In general, in transformable wheel-leg robot studies, the leg and wheel structure perform their movements in an interdependent manner. However, in this study, it is aimed to design a robot in which the leg and wheel structure can move independently of each other and to develop a robot that can easily overcome obstacles on flat surfaces with the wheel mode and with the leg mode. The robot can fold its legs hidden within the wheels and deploy its two degree of freedom (DoF) legs when it detects step-like obstacles. This mechanism allows the robot to overcome an obstacle with a height of twice the radius of the robot's open/close mechanism of the legs, along with the two-dimensional kinematic and dynamic analyzes of the legs, are presented in detail within the scope of this study proportional-integral-derivative (PID) controller is designed to control the joint angles of the legs. The reference angle values to be followed according to the height of the obstacle are determined using artificial neural network (ANN). Additionally, motion simulations of the robot are conducted for four different obstacle heights (20, 30, 40, and 50 cm). As a result of the PID controller, when exceeding the highest obstacle of 50 cm, the average absolute joint angular tracking error is max. 1.8829°, average tracking error max. 0.265 s and max.
A systematic review of TPACK research in primary mathematics education
Authors: Li Mao , Vale Colleen , Tan Hazel , Blannin Jo 
Published: May 2024

AbstractThis study is a systematic review of Technological Pedagogical and Content Knowledge (TPACK) studies concerning primary mathematics education published between 2005 and 2022. The aim of the systematic review was to identify the common features of previous TPACK research on primary mathematics education and identify the research gaps based on their contexts. The study used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) procedure to investigate TPACK-related studies published during the last 17 years in the primary mathematics education domain and to evaluate the characteristics of TPACK instruments used in primary mathematics education. We identified five foci of these studies of TPACK in primary mathematics education research: designing lessons, evaluating mathematics teachers’ knowledge of integrating digital technologies, designing the assessment, evaluating training programs, and informing professional development program designs. Findings from this systematic review of the literature can assist educators in better designing professional development programs to help primary mathematics teachers improve their ability to integrate digital technology into classroom teaching. Also, the findings can assist researchers in locating TPACK instruments that are appropriate and relevant for their research. Finally, we argue that there is a research gap concerning how to measure primary mathematics teachers’ TPACK, how to design a TPACK instrument that includes contextual factors, and how to develop TPACK-oriented teacher training programs for primary mathematics teachers.
VBP1 promotes tumor proliferation as a part of the hypoxia-related signature in esophageal squamous cell carcinoma
Authors: Miao Huikai , Gao Wuyou , Zhong Leqi , Li Hongmu , Chen Dongni , Xu Chunmei , Wen Zhesheng , Chen Youfang 
Published: May 2024

AbstractEsophageal squamous cell carcinoma (ESCC) is a common malignant tumor in East Asia. Hypoxia, a hallmark of solid tumors, significantly alters redox homeostasis inside tumor microenvironment. This alteration drives tumor proliferation, invasion, and metastasis, leading to poor prognostic outcomes. However, the role of hypoxia-related genes in ESCC remains poorly understood. We employed RNA sequencing to identify differentially expressed genes in ESCC. Clinical data, transcriptome profiles, and a hypoxia-related gene set were extracted from open-source databases. A prognostic model was constructed using least absolute shrinkage and selection operator (LASSO) regression, which was then validated through Cox regression analysis. Within this prognostic model, we pinpointed and investigated a key hypoxia-related gene affecting prognosis. The gene's expression was validated using real-time PCR and immunohistochemistry in both esophageal carcinoma and normal tissues. Tumor proliferation was examined through in vitro and in vivo assays, including the Cell Counting Kit-8, EdU, colony formation, and subcutaneous tumor models. A robust four-gene prognostic model (VBP1, BGN, CDKN1A, and PPFIA1) was successfully constructed and validated. Among these, VBP1 emerged as a key gene, exhibiting high expression levels that correlated with poor prognosis in ESCC. Functional experiments confirmed that VBP1 significantly accelerated tumor proliferation both in vitro and in vivo. VBP1 is identified as a pivotal gene within the hypoxia-related prognostic signature, and it significantly promotes tumor proliferation in ESCC.
TiO2 Electron Transport Layer with p–n Homojunctions for Efficient and Stable Perovskite Solar Cells
Authors: Zhao Wenhao , Guo Pengfei , Wu Jiahao , Lin Deyou , Jia Ning , Fang Zhiyu , Liu Chong , Ye Qian , Zou Jijun , Zhou Yuanyuan , Wang Hongqiang 
Published: May 2024

AbstractLow-temperature processed electron transport layer (ETL) of TiO2 that is widely used in planar perovskite solar cells (PSCs) has inherent low carrier mobility, resulting in insufficient photogenerated electron transport and thus recombination loss at buried interface. Herein, we demonstrate an effective strategy of laser embedding of p-n homojunctions in the TiO2 ETL to accelerate electron transport in PSCs, through localized build-in electric fields that enables boosted electron mobility by two orders of magnitude. Such embedding is found significantly helpful for not only the enhanced crystallization quality of TiO2 ETL, but the fabrication of perovskite films with larger-grain and the less-trap-states. The embedded p–n homojunction enables also the modulation of interfacial energy level between perovskite layers and ETLs, favoring for the reduced voltage deficit of PSCs. Benefiting from these merits, the formamidinium lead iodide (FAPbI3) PSCs employing such ETLs deliver a champion efficiency of 25.50%, along with much-improved device stability under harsh conditions, i.e., maintain over 95% of their initial efficiency after operation at maximum power point under continuous heat and illumination for 500 h, as well as mixed-cation PSCs with a champion efficiency of 22.02% and over 3000 h of ambient storage under humidity stability of 40%. Present study offers new possibilities of regulating charge transport layers via p-n homojunction embedding for high performance optoelectronics.
A Paperless and 3D Workflow for Documenting Excavations at Insula I.14, Pompeii, Italy
Authors: Badillo Alex Elvis , Brennan Matthew R. , Estes Aaron M. , Aldrich Stephen P. , Emmerson Allison L. C. 
Published: May 2024

ABSTRACTIn the summer of 2022, Tulane University, in collaboration with archaeologists from other institutions, began excavations at the site of Pompeii. The archaeological work was focused on Insula 14 of Region 1, located in the southeastern sector of the site. To overcome the challenges of recording a complex urban excavation, and of working with a collaborative team, we designed and implemented a unique workflow that combines paperless and 3D data-capture methods through the use of GIS technologies. The final product of our documentation workflow was a robust and easy-to-use online geodatabase where archaeologists can revisit, explore, visualize, and analyze each excavated context using virtual tools. We present our workflow for digitally documenting observational and spatial data in the field, and how we made these data available to project archaeologists during and after the field season. First, we describe the development of digital forms in ESRI's Survey123. Then, we explain our procedures for 3D documentation through SfM photogrammetric methods and discuss how we integrated the data and transformed it into an accessible format by using interactive dashboards and online 3D web scenes. Finally, we discuss the components of our workflow that are broadly applicable and that can easily be adapted to other projects.
Facility- and patient-level factors associated with implementation of contact precautions in hospitalized VA patients with positive CRE cultures
Authors: Wilson Geneva M. , Fitzpatrick Margaret , Suda Katie J. , Poggensee Linda , Jones Makoto , Evans Martin E. , Evans Charlesnika T. 
Published: May 2024

Abstract
Decreasing the time to contact precautions (CP) is critical to carbapenem-resistant Enterobacterales (CRE) prevention. Identifying factors associated with delayed CP can decrease the spread from patients with CRE. In this study, a shorter length of stay was associated with being placed in CP within 3 days.