bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterns of sub‐optimal change following CBT for childhood anxiety
Authors: Bertie Lizel‐Antoinette , Arendt Kristian , Coleman Jonathan R. I. , Cooper Peter , Creswell Cathy , Eley Thalia C. , Hartman Catharina , Heiervang Einar R. , In‐Albon Tina , Krause Karen , Lester Kathryn J. , Marin Carla E. , Nauta Maaike , Rapee Ronald M. , Schneider Silvia , Schniering Carolyn , Silverman Wendy K. , Thastum Mikael , Thirlwall Kerstin , Waite Polly , Wergeland Gro Janne , Hudson Jennifer L. 
Published: May 2024

BackgroundChildren and adolescents demonstrate diverse patterns of symptom change and disorder remission following cognitive behavioural therapy (CBT) for anxiety disorders. To better understand children who respond sub‐optimally to CBT, this study investigated youths (N = 1,483) who continued to meet criteria for one or more clinical anxiety diagnosis immediately following treatment or at any point during the 12 months following treatment.MethodsData were collected from 10 clinical sites with assessments at pre‐and post‐treatment and at least once more at 3, 6 or 12‐month follow‐up. Participants were assigned to one of three groups based on diagnostic status for youths who: (a) retained an anxiety diagnosis from post to end point (minimal responders); (b) remitted anxiety diagnoses at post but relapsed by end point (relapsed responders); and (c) retained a diagnosis at post but remitted to be diagnosis free at end point (delayed responders). Growth curve models assessed patterns of change over time for the three groups and examined predictors associated with these patterns including demographic, clinical and parental factors, as well as treatment factors.ResultsHigher primary disorder severity, being older, having a greater number of anxiety disorders, having social anxiety disorder, as well as higher maternal psychopathology differentiated the minimal responders from the delayed and relapsed responders at the baseline. Results from the growth curve models showed that severity of the primary disorder and treatment modality differentiated patterns of linear change only. Higher severity was associated with significantly less improvement over time for the minimal and relapsed response groups, as was receiving group CBT, when compared to the delayed response group.ConclusionsSub‐optimal response patterns can be partially differentiated using variables assessed at pre‐treatment. Increased understanding of different patterns of change following treatment may provide direction for clinical decision‐making and for tailoring treatments to specific groups of clinically anxious youth. Future research may benefit from assessing progress during treatment to detect emerging response patterns earlier.
Modeling Response Styles in Cross‐Classified Data Using a Cross‐Classified Multidimensional Nominal Response Model
Authors: Huang Sijia , Chung Seungwon , Falk Carl F. 
Published: May 2024

AbstractIn this study, we introduced a cross‐classified multidimensional nominal response model (CC‐MNRM) to account for various response styles (RS) in the presence of cross‐classified data. The proposed model allows slopes to vary across items and can explore impacts of observed covariates on latent constructs. We applied a recently developed variant of the Metropolis‐Hastings Robbins‐Monro (MH‐RM) algorithm to address the computational challenge of estimating the proposed model. To demonstrate our new approach, we analyzed empirical student evaluation of teaching (SET) data collected from a large public university with three models: a CC‐MNRM with RS, a CC‐MNRM with no RS, and a multilevel MNRM with RS. Results indicated that the three models led to different inferences regarding the observed covariates. Additionally, in the example, ignoring/incorporating RS led to changes in student substantive scores, while the instructor substantive scores were less impacted. Misspecifying the cross‐classified data structure resulted in apparent changes on instructor scores. To further evaluate the proposed modeling approach, we conducted a preliminary simulation study and observed good parameter and score recovery. We concluded this study with discussions of limitations and future research directions.
Difference between kidney function by cystatin C versus creatinine and association with muscle mass and frailty
Authors: Yuan Julia H. , Rifkin Dena E. , Ginsberg Charles , Cawthon Peggy M. , Kado Deborah M. , Bauer Scott R. , Ensrud Kristine E. , Hoffman Andrew R. , Potok O. Alison 
Published: May 2024

AbstractBackgroundA higher difference in estimated glomerular filtration rate by cystatin C versus creatinine (eGFRDiff = eGFRCys – eGFRCreat) is associated with decreased frailty risk. Since eGFRCreat is influenced by muscle more than eGFRCys, muscle mass may explain this association. Previous work could not account for this when considering regional muscle measures by imaging. Deuterated creatine (D3Cr) dilution measures whole body muscle mass (kilograms). We aimed to determine whether eGFRDiff is associated with D3Cr muscle mass and whether muscle mass explains the association between eGFRDiff and frailty.MethodsCross‐sectional analysis within the multicenter MrOS Study at Year 14 (visit 4). 490 men of the original cohort of 5994 MrOS participants (aged ≥65 at enrollment) were included. Exposure was eGFRDiff (= eGFRCys – eGFRCreat), calculated using CKD‐EPI equations 2012/2021. Primary outcome was D3Cr muscle mass. Secondary outcome was phenotypic pre‐frailty (one or two criteria) and frailty (≥three criteria) including the following: weight loss, weakness, slow gait, physical activity, poor energy. The association of eGFRDiff with D3Cr muscle mass was examined by linear regression, that with prefrailty / frailty by multinomial logistic regression.ResultsMean ± SD age was 84 ± 4 years, eGFRCreat 68 ± 16, eGFRCys 52 ± 16, eGFRDiff −15 ± 12 mL/min/1.73 m2 and D3Cr muscle mass 24 ± 4 kg. For each SD increment in eGFRDiff, D3Cr muscle mass was 1.4 kg higher on average, p < 0.0001 (fully adjusted). Higher eGFRDiff was associated with lower odds of frailty (OR = 0.63 95% CI [0.45;0.89]), but this was partially attenuated and insignificant after additionally adjusting for D3Cr muscle mass (OR = 0.85 95% CI [0.58; 1.24]).ConclusionsHigher eGFRDiff is associated with lower odds of frailty among late‐life men. D3Cr muscle mass accounts for some of this association. This suggests that non‐GFR determinants of creatinine and cystatin C, such as muscle mass, play a role in explaining the association of eGFRDiff with frailty. Future studies are needed to confirm.
Transcription factor OsWRKY11 induces rice heading at low concentrations but inhibits rice heading at high concentrations
Authors: Zhao Lirong , Liu Yunwei , Zhu Yi , Chen Shidie , Du Yang , Deng Luyao , Liu Lei , Li Xia , Chen Wanqin , Xu Zhiyu , Xiong Yangyang , Ming You , Fang Siyu , Chen Ligang , Wang Houping , Yu Diqiu 
Published: May 2024

ABSTRACTThe heading date of rice is a crucial agronomic characteristic that influences its adaptability to different regions and its productivity potential. Despite the involvement of WRKY transcription factors in various biological processes related to development, the precise mechanisms through which these transcription factors regulate the heading date in rice have not been well elucidated. The present study identified OsWRKY11 as a WRKY transcription factor which exhibits a pivotal function in the regulation of the heading date in rice through a comprehensive screening of a clustered regularly interspaced palindromic repeats (CRISPR) ‒ CRISPR‐associated nuclease 9 mutant library that specifically targets the WRKY genes in rice. The heading date of oswrky11 mutant plants and OsWRKY11‐overexpressing plants was delayed compared with that of the wild‐type plants under short‐day and long‐day conditions. Mechanistic investigation revealed that OsWRKY11 exerts dual effects on transcriptional promotion and suppression through direct and indirect DNA binding, respectively. Under normal conditions, OsWRKY11 facilitates flowering by directly inducing the expression of OsMADS14 and OsMADS15. The presence of elevated levels of OsWRKY11 protein promote formation of a ternary protein complex involving OsWRKY11, Heading date 1 (Hd1), and Days to heading date 8 (DTH8), and this complex then suppresses the expression of Ehd1, which leads to a delay in the heading date. Subsequent investigation revealed that a mild drought condition resulted in a modest increase in OsWRKY11 expression, promoting heading. Conversely, under severe drought conditions, a significant upregulation of OsWRKY11 led to the suppression of Ehd1 expression, ultimately causing a delay in heading date. Our findings uncover a previously unacknowledged mechanism through which the transcription factor OsWRKY11 exerts a dual impact on the heading date by directly and indirectly binding to the promoters of target genes.
Current opinion on the prospect of mapping electronic orbitals in the transmission electron microscope: State of the art, challenges and perspectives
Authors: Bugnet M. , Löffler S. , Ederer M. , Kepaptsoglou D. M. , Ramasse Q. M. 
Published: May 2024

AbstractThe concept of electronic orbitals has enabled the understanding of a wide range of physical and chemical properties of solids through the definition of, for example, chemical bonding between atoms. In the transmission electron microscope, which is one of the most used and powerful analytical tools for high‐spatial‐resolution analysis of solids, the accessible quantity is the local distribution of electronic states. However, the interpretation of electronic state maps at atomic resolution in terms of electronic orbitals is far from obvious, not always possible, and often remains a major hurdle preventing a better understanding of the properties of the system of interest. In this review, the current state of the art of the experimental aspects for electronic state mapping and its interpretation as electronic orbitals is presented, considering approaches that rely on elastic and inelastic scattering, in real and reciprocal spaces. This work goes beyond resolving spectral variations between adjacent atomic columns, as it aims at providing deeper information about, for example, the spatial or momentum distributions of the states involved. The advantages and disadvantages of existing experimental approaches are discussed, while the challenges to overcome and future perspectives are explored in an effort to establish the current state of knowledge in this field. The aims of this review are also to foster the interest of the scientific community and to trigger a global effort to further enhance the current analytical capabilities of transmission electron microscopy for chemical bonding and electronic structure analysis.
Effect of different materials of filter holder on sensory profile of coffee beverages
Authors: Santos Wallysson Wagner Vilela , Lima Kellyson Leandro Barbosa , de Lucena Rodrigo Mendonça , de Arruda Luciana Leite Andrade Lima , de Oliveira Rodrigo Lira , dos Santos Silva Marcelo Edvan , da Silva Suzana Pedroza 
Published: May 2024

AbstractCoffee beverages are renowned for their complex chemical composition and sensory attributes. The Koar® filter holder, developed in Brazil, is an extraction method which utilizes percolation and is available in acrylic, stainless steel, ceramic, and porcelain variations. Thus, this study aimed to investigate how the manufacturing materials of Koar® filter holders impact the sensory profile of coffee beverages, as perceived by consumers. A group of 100 consumers were used, and the methods of check all that apply (CATA), and acceptance testing were applied. The results revealed significant variations in eight sensory attributes assessed by consumers. The beverages prepared with ceramic and porcelain filter holders exhibited similar sensory profiles, contrasting with those produced using acrylic and stainless steel. These sensory findings emphasize the impact of the Koar® filter holder material on the coffee beverage's sensory attributes and underscore the importance of understanding the specific perceptions and needs of the target audience.Practical applicationsConsidering the importance of the studies with consumers, this research presents findings that are very important for industries in the equipment production segment for the coffee beverage extraction process. Based on the results presented in this study, industries can develop products with specific materials that can enhance the sensorial attributes of the coffee beverage according to consumer preference.
Point‐of‐care diabetes testing in the dental setting: A national scope of practice survey
Authors: Laniado Nadia , Brodigan Ashley E. , Cloidt Megan 
Published: May 2024

AbstractObjectivesThe aim of this study was to assess the knowledge of state dental directors regarding their state's professional practice act, specifically scope of practice laws regarding point‐of‐care chairside screening for diabetes.MethodsA cross‐sectional study design was used to examine the 50 state dental directors' knowledge of policy around point‐of‐care diabetes testing in their state. A five‐item survey instrument was designed in a web‐based platform and electronically distributed in 2022.ResultsThirty‐seven states (74%) responded to the survey. Regarding whether it was within the scope of practice for dentists to provide chairside point‐of‐care HbA1c screening, 17 states (46.0%) responded “yes,” 5 states (13.5%) responded “no,” and 15 states (40.5%) responded “don't know.” Of the 17 states who provide diabetes testing, four states (23.5%) reported that dentists were reimbursed, nine states (53.0%) reported they were not reimbursed, and four states (23.5%) reported they did not know regarding reimbursement.ConclusionsThere is significant state heterogeneity with regard to laws, regulations, and reimbursement for chairside diabetes testing in the United States. This is accompanied by vagueness and lack of specificity in the state education laws. For more widespread promotion and adoption of this evidence‐based screening, the entire dental community including clinicians, educators, policymakers, payers, and professional organizations at all levels are encouraged to work together to advocate for clarification and specificity in the language of state education laws as well as reimbursement for this vital service.
Internet memes and copyright: Facilitating the memetic remix discourse by viewing joint authorship flexibly?
Authors: Leung Brian 
Published: May 2024

AbstractInteractions between internet meme culture and copyright law are inherently complex: online communities often do not seek express permission from rightsholders of underlying work to recreate internet memes. However, internet meme culture can be tremendously valuable from sociocultural and economic standpoints. As such, there are apparent benefits if copyright law could integrate the memetic remix discourse within its evaluations in a systematic manner. To this end, this article entertains the merits of interpreting the joint authorship test flexibly, as one of the many possible ways to integrate the memetic remix discourse in UK copyright law. Such a systematic and integrated approach may better reflect internet meme culture. It allows copyright to prevent selective enforcement because rightsholders of underlying works will not enjoy sole control over the use of their work once they become viral internet memes. It also paves way for copyright law to systematically facilitate underlying works to evolve into viral internet memes without a constant dread of retrospective takedowns and infringement claims.
Making kin is more than metaphor: Implications of responsibilities toward Indigenous knowledge and artistic traditions for museums
Authors: Isaac Gwyneira , Burgio‐Ericson Klint , McChesney Lea , Green Adriana Greci , Charley Karen Kahe , Church Kelly , Dillard Renee Wasson 
Published: May 2024

AbstractMany Indigenous communities do not regard objects as inanimate, but rather as animate kin. Based on our work as a collaborative group of museum coordinators and Hopi, Anishinaabe, and Penobscot artists, we explore narratives and kinship concepts emerging from working with collections of baskets and pottery. We question how recent theoretical conceptualizations of kinship have become overly rhetorical and, therefore, risk diminishing the tangible responsibilities that Indigenous knowledge systems teach. We explore how the new social networks forged through collaborative practices implicate museum personnel in kinship‐like relationships, which raises the question: What are the critical lessons museums can learn from the work of making and sustaining kin? Conventional western museology rarely contemplates these imperatives. The implications for museums that come with recognizing such networks are not only about conceptualizing kin in new ways, but also developing shared ethical protocols and responsibilities toward Indigenous knowledge and the environment over multiple generations.
Clinical aspects of oral cancer and potentially malignant disorders in South and Southeast Asia
Authors: Ranganathan Kannan , Kavitha Loganathan 
Published: May 2024

AbstractBackgroundOral cancer and Oral Potentially Malignant Disorders (OPMD) are major health problems in South and Southeast Asia.AimsTo describe and discuss the clinical aspects of Oral Cancer and OPMD in South and Southeast Asia.Materials and MethodsLiterature review of concepts and data over the last four decades.DiscussionAsian countries account for about two‐thirds of new cases of oral cancer (OC) globally, with the highest burden in the South and Southeast Asian countries, including Pakistan and India. Habits, dietary patterns, socioeconomic status, and access to routine dental care play a crucial role in defining the demographics and clinical presentation of OC in these regions and significantly influence the morbidity and mortality of the disease. This region sees the use of different types of tobacco with or without areca nut (AN), such as pan masala, gutka, gul, snuff, mawa, and mishri. Tobacco use is high among men in Sri Lanka, Myanmar, Maldives, Bangladesh, Nepal, India and Bhutan. Areca nut is the fourth most common addictive substance globally and is frequently used in South and Southeast Asian countries, including Southeast China, Hainan Island, India, Taiwan, and the Pacific Islands, and immigrants from these regions in Africa, Europe, and North America. The use of these products results in mucosal alterations with varied clinical presentation of Oral Potentially Malignant Disorders (OPMDs) and OC. We discuss here the different types of OPMD and OC, the diagnostic aids and their relevance in clinical practice, and factors that influence their prognosis.
CmBr confers fruit bitterness under CPPU treatment in melon
Authors: Wang Mingyan , Jiang Naiyu , Xu Yuanchao , Chen Xinxiu , Wang Cui , Wang Chuangjiang , Wang Shiqi , Xu Kuipeng , Chai Sen , Yu Qing , Zhang Zhonghua , Zhang Huimin 
Published: May 2024

SummaryMany biotic or abiotic factors such as CPPU (N‐(2‐chloro‐pyridin‐4‐yl)‐N′‐phenylurea), a growth regulator of numerous crops, can induce bitterness in cucurbits. In melon, cucurbitacin B is the major compound leading to bitterness. However, the molecular mechanism underlying CuB biosynthesis in response to different conditions remains unclear. Here, we identified a set of genes involved in CPPU‐induced CuB biosynthesis in melon fruit and proposed CmBr gene as the major regulator. Using CRISPR/Cas9 gene editing, we confirmed CmBr's role in regulating CuB biosynthesis under CPPU treatment. We further discovered a CPPU‐induced MYB‐related transcription factor, CmRSM1, which specifically binds to the Myb motif within the CmBr promoter and activates its expression. Moreover, we developed an introgression line by introducing the mutated Cmbr gene into an elite variety and eliminated CPPU‐induced bitterness, demonstrating its potential application in breeding. This study offers a valuable tool for breeding high‐quality non‐bitter melon varieties and provides new insights into the regulation of secondary metabolites under environmental stresses.
Responding to second‐order reasons
Authors: Keeling Sophie 
Published: May 2024

AbstractA rich literature has discussed what it is to respond to a reason, e.g., to believe or act on the basis of some consideration or another. In comparison, what it would be to respond to a second‐order reason has been underexplored. Yet formulating an account of this is vital for maintaining the existence of second‐order reasons in both the practical and epistemic domains. And indeed, there are reasons to doubt this is possible. For example, responding to second‐order reasons is meant to be different from simply coming to believe or act for a more richly described first‐order reason but it's not clear what this would look like. This paper introduces an account of the second‐order basing relation which meets these concerns. It therefore both develops our picture of second‐order reasons and helps to defend their existence.
Growth kinetics, spatialization and quality of potato tubers monitored in situ by MRI ‐ long‐term effects of water stress
Authors: Musse Maja , Hajjar Ghina , Radovcic Aël , Ali Nusrat , Challois Sylvain , Quellec Stéphane , Leconte Patrick , Carillo Aurélien , Langrume Christophe , Bousset‐Vaslin Lydia , Billiot Bastien , Jamois Frank , Joly Gisèle , Deleu Carole , Leport Laurent 
Published: May 2024

AbstractUnderstanding the potato tuber development and effects of drought at key stages of sensitivity on yield is crucial, particularly when considering the increasing incidence of drought due to climate change. So far, few studies addressed the time course of tuber growth in soil, mainly due to difficulties in accessing underground plant organs in a non‐destructive manner. This study aims to understand the tuber growth and quality and the complex long‐term effects of realistic water stress on potato tuber yield. MRI was used to monitor the growth kinetics and spatialization of individual tubers in situ and the evolution of internal defects throughout the development period.The intermittent drought applied to plants reduced tuber yield by reducing tuber growth and increasing the number of aborted tubers. The reduction in the size of tubers depended on the vertical position of the tubers in the soil, indicating water exchanges between tubers and the mother plant during leaf dehydration events. The final size of tubers was linked with the growth rate at specific developmental periods. For plants experiencing stress, this corresponded to the days following rewatering, suggesting tuber growth plasticity. All internal defects occurred in large tubers and within a short time span immediately following a period of rapid growth of perimedullary tissues, probably due to high nutrient requirements. To conclude, the non‐destructive 3D imaging by MRI allowed us to quantify and better understand the kinetics and spatialization of tuber growth and the appearance of internal defects under different soil water conditions.