bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histopatologi Hati Mencit (Mus Musculus) yang Diberikan Minuman Ringan Berkarbonasi dan Ekstrak Daun Kersen (Muntingia Calabura L.)
Authors: Azhim Ash Siddiq Muhammad Nuzul , Majiding Chaidir Masyhuri , Rozi Fahrul , Winarsih Wiwin 
Published: May 2024

High consumption of carbonated soft drinks (CSD) has caused risks of metabolic syndrome, obesity, various chronic diseases, and organ damage. Kersen has the potential to prevent and reduce damage to the liver caused by CSD. The study aimed to analyze the liver histopathological of mice given CSD and the effect of Kersen leaf extract. This experimental study used a completely randomized design with 25 male white mice divided into 5 groups, namely control grup (K), negative control (N), treatment 1, 2, and 3 with doses (35 mg/30g BW, 45 mg/30g BW, 65 mg/30g BB) for 30 days. The sample was terminated on the 31st day, and the liver organs were prepared to observe the microscopic of the liver. The analytical test used the ANOVA test with Duncan's multiple-range test. The results showed that the negative control group had significantly lower numbers of liver cell damage than the positive controls who were given CSD (p<0.05), and the treatment groups 2 and 3 also had significantly less cell damage than the positive control group and did not significantly different from the negative control group. Kersen leaf extract can prevent and reduce liver cell damage in carbonated soft drink-induced mice.

Keywords: Liver, Histopathology, Kersen, Mice, Soft drink

Abstrak
Konsumsi minuman berkarbonasi/ carbonated soft drink (CSD) yang berlebih berisiko menyebabkan terjadinya sindrom metabolik, obesitas, berbagai penyakit kronis, dan kerusakan organ. Kersen berpotensi mencegah dan mengurangi kerusakan pada hati yang disebabkan oleh CSD. Penelitian ini bertujuan untuk melihat gambaran histopatologi hati mencit yang diberikan minuman CSD dan efek pemberian ekstrak daun kersen. Penelitian experimental ini menggunakan rancangan acak lengkap dengan 25 mencit putih jantan yang dibagi 5 kelompok yaitu kelompok kontrol (K), kontrol negatif (N), perlakuan 1, 2, dan 3 dengan dosis (35 mg/30g BB, 45 mg/30g BB, 65 mg/30g BB) selama 30 hari. Sampel diterminasi pada hari ke 31 dan organ hepar dibuat preparat untuk diamati gambaran mikroskopis hati. Uji analisis menggunakan uji beda ANOVA dengan uji lanjut Duncan’s multiple-range test. Hasil pengamatan menunjukkan bahwa kelompok kontrol negatif memiliki jumlah kerusakan sel hati yang signifikan lebih rendah dibandingkan dengan kontrol positif yang diberikan CSD (p<0.05) dan kelompok perlakuan 2 dan 3 juga signifikan memiliki jumlah kerusakan sel yang lebih sedikit dibandingkan kelompok kontrol positif serta tidak berbeda signifikan dengan kelompok kontrol negatif. Ekstrak daun kersen memberikan pengaruh terhadap pencegahan dan mengurangi kerusakan sel hati pada mencit putih yang diberikan CSD.

Kata Kunci: Hepar, Histopatologi, Kersen, Mencit, Carbonated Soft Drink
Audiovisual Motivasi Berbasis Android pada Pasien Tuberkulosis di Puskesmas Kabupaten Banjar Kalimantan Selatan
Authors: Santoso Trias Budi , Kartinah Nani , Sari Okta Muthia 
Published: May 2024

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Many problems arise, including dropping out of therapy due to the long duration of treatment. The study's goal was to determine the percentage of motivation before-after using the Android application and the satisfaction of tuberculosis patients. The study used a pre-experimental design with one group pre-test and post-test. In May 2021, the study population consisted of tuberculosis patients at the Banjar Public Health Centre who satisfied the research criteria. Respondents used the programme for 7 days and completed a questionnaire on the last day. Twelve respondents met the research criteria. The results showed an average percentage of pretest motivation of 78.20% and a posttest percentage of 80.29%. The findings of the level of satisfaction of the respondents after using audiovisuals were 66.5%. In summary, the Android-based audiovisual for tuberculosis patients that has been developed increases patient motivation and satisfaction.

Keywords: satisfaction, motivation, taking medications, smartphone

Abstrak
Tuberkulosis termasuk penyakit infeksi menular disebabkan oleh bakteri Mycobacterium tuberculosis. Permasalahan yang banyak terjadi yaitu putus berobat dikarenakan durasi pengobatan yang panjang sehingga memerlukan motivasi tinggi agar dapat menjalani pengobatan hingga selesai. Tujuan penelitian mengukur persentase motivasi sebelum dan sesudah penggunaan aplikasi android dan kepuasan pasien tuberkulosis terhadap aplikasi android. Penelitian merupakan pre-experimental designs dengan one group pre-test post-test design dan pengambilan data prospektif menggunakan kuesioner. Populasi penelitian yaitu pasien tuberkulosis di Puskesmas Kabupaten Banjar bulan Mei tahun 2021 dan memenuhi kriteria penelitian. Responden menggunakan aplikasi selama 7 hari dan pada hari terakhir diukur motivasi dan tingkat kepuasan menggunakan kuesioner. Sebanyak 12 responden memenuhi kriteria penelitian. Hasil penelitian memperoleh rerata persentase motivasi pre-test sebesar 78,20% dan post-test sebesar 80,29%. Hasil tingkat kepuasan responden setelah penggunaan audiovisual sebesar 66,5% yang termasuk kategori puas. Kesimpulan audiovisual berbasis android untuk pasien tuberkulosis yang telah dirancang membantu meningkatkan motivasi pasien dan memberikan kepuasan.

Kata Kunci: kepuasan, motivasi, minum obat, smartphone
Studi In Silico Senyawa Bioaktif Daun Miana (Coleus scutellariodes (L). Benth) sebagai Inhibitor Enzim Asetikolineterase (Ache) pada Alzheimer
Authors: Vitadella Veronika , Bulan Catherine Putri , Sinurat Julius Alvin Novensius , Latief Madyawati , Yusnaidar Yusnaidar , Tarigan Indra Lasmana 
Published: May 2024

Abstract
Alzheimer's contamination is a neurodegenerative sickness brought about by a decline in the blend of acetylcholine because of the breakdown of acetylcholine into choline and the determination of acidic corrosive by the compound Acetylcholinesterase (Hurt). Compounds known to have heartbeat restraining developments are promising medications for the treatment of these contaminations. In this investigation, in-silico studies were done on the blend found in Miana (Coleus) further to see whether this combination could be utilized as a remedial application in the treatment of Alzheimer's illness utilizing sub-nuclear docking procedures. From the consequences of the examination, it is realized that the Pyrazolopyridine compound is the best medication contender with a limiting energy and stable limitation benefit of - 6.96 kcal/mol and 7.95 µm separately, with hydrogen securities happening in the destructive development of amino SER 293.

Keywords: Alzheimer’s; In Silico; Miana

Abstrak
Penyakit Alzheimer adalah infeksi neurodegenerative, dan terjadi karena menurunnya kombinasi asetilkolin dampak dari penguraian asetilkolin menjadi kolin dan derivasi asam asetat oleh senyawa Asetilkolinesterase (Hurt). Larutan yang diketahui memiliki gerakan penghambatan denyut merupakan obat yang menjanjikan untuk pengobatan infeksi ini. Dalam eksplorasi ini, studi in-silico dilakukan pada campuran yang ditemukan di Miana (Coleus) selanjutnya untuk melihat apakah campuran ini dapat digunakan sebagai aplikasi pengobatan dalam pengobatan penyakit Alzheimer dengan menggunakan strategi docking sub-atomik. Dari hasil penyelidikan diketahui bahwa senyawa Pyrazolopyridine adalah pesaing obat terbaik dengan energi ikatan dan keuntungan stabil pengekangan masing-masing - 6,96 kkal/mol dan 7,95 µm, dengan ikatan hidrogen terjadi pada penumpukan korosif amino SER 293.

Kata Kunci: Alzheimer’s; In Silico; Miana
Kajian Daya Dukung Tanah Lempung Distabilisasi dengan Abu Marmer
Authors: Waruwu Aazokhi , Celline Felicia , Sinaga Rionaldi , Gandawijaya Darryl Gregory 
Published: May 2024

[ID] Tanah dasar memiliki peranan penting dalam menjaga keamanan dan kestabilan konstruksi yang dibangun di atasnya. Tanah dasar perlu dipastikan berada di dalam kondisi yang baik dan mampu memberikan dukungan terhadap beban yang bekerja. Salah satu jenis tanah bermasalah adalah tanah lempung lunak. Tanah ini memiliki daya dukung rendah, sehingga memerlukan perbaikan sebelum pembangunan konstruksi di atasnya. Salah satu metode perbaikan tanah adalah stabilisasi. Bahan stabilisasi yang dipertimbangkan pada penelitian adalah abu marmer dari limbah marmer. Karakterisitik tanah yang ditinjau di antaranya indeks plastisitas, kepadatan, dan kohesi undrained. Indeks plastisitas tanah dapat diperoleh dengan melakukan uji Atterberg, kepadatan tanah dari uji kompaksi, dan kohesi undrained dari unconfined compression test. Kadar abu marmer yang digunaka adalah sebesar 3%, 6%, 9%, dan 12% dari berat kering tanah dengan variasi pemeraman 1 hari, 7 hari, 14 hari, dan 28 hari. Daya dukung tanah dapat dianalisis berdasarkan kohesi undrained pada setiap kadar abu marmer yang digunakan. Hasil penelitian menunjukkan perbaikan nilai indeks plastisitas, kepadatan, dan kohesi undrained tanah untuk setiap penambahan abu marmer, namun peningkatan yang optimal didapatkan pada penambahan 6% abu marmer dengan masa pemeraman maksimum 7 hari. Daya dukung tanah didapatkan meningkat secara maksimum pada penambahan abu marmer sebanyak 6% dan pemeraman 7 hari.
[EN] Subgrade soil has an important role in maintaining the safety and stability of construction built on it. One type of problematic soil is soft clay. This land has a low bearing capacity, so it requires improvement before building on it. The aim of this research is to obtain changes in the bearing capacity of soil stabilized by marble ash. This research was carried out on soft clay soil with the addition of marble ash at 3%, 6%, 9%, and 12% of the dry weight of the soil with curing variations of 1 day, 7 days, 14 days, and 28 days. The soil characteristics reviewed include plasticity index, density, and undrained cohesion. Soil bearing capacity can be analyzed based on undrained cohesion at each level of marble ash used. The results showed an improvement in the plasticity index value from 33.82% dencreased to 7.69%; density with a dry unit weight of 1.50 gr/cm3 increased to 1.55 gr/cm3; and soil undrained cohesion increased from 0.134 kg/cm2 to 1.58 kg/cm2 due to the addition of marble ash. Optimal improvements in soil characteristics and bearing capacity were obtained by adding 6% marble ash with a maximum curing period of 7 days.
دور الإدارة الرشيقة في رفع الأداء الوظيفي: دراسة تطبيقية على وزارة الصحة في المملكة العربية السعودية
Authors: العتيبي منيرة مسلط فيحان 
Published: May 2024

هدفت الدراسة إلى التعرف على دور الإدارة الرشيقة في رفع الأداء الوظيفي في وزارة الصحة في المملكة العربية السعودية، واتبعت الدراسة استخدام المنهج الوصفي التحليلي، كما تم الاعتماد على الاستبانة كأداة لجمع المعلومات الأولية, وتكون مجتمع الدراسة من موظفي وزارة الصحة في المملكة العربية السعودية, حيث تم دراسة عينة عشوائية بسيطة بلغ حجمها (514) فرد، وقد خلصت نتائج البحث إلى مجموعة من النتائج الرئيسة منها: أن مستوى ممارسة الإدارة الرشيقة ومستوى الأداء الوظيفي في وزارة الصحة في المملكة العربية السعودية جاءا بدرجة مرتفعة, وأن الإدارة الرشيقة بأبعادها (التحسين المستمر، تنظيم العمل، العمل القياسي، الحيود السداسي) تؤثر تأثيراً إيجابياً في رفع الأداء الوظيفي إذ بلغت نسبة التأثير 79.6%, ماعدا بُعد (الموظفين متعددي الوظائف) لا يوجد له تأثير في رفع الأداء الوظيفي في وزارة الصحة في المملكة العربية السعودية, وأوصت الدراسة بضرورة الاهتمام بأدوات الإدارة الرشيقة والتوسع في تطبيقها؛ لما لها من أثر في إيجاد الحلول الجذرية التي تقلل نسبة الهدر في المنظمة، كما أوصت بالعمل على تقليل الضغط على الموظفين والتشجيع على الابتكار وتوليد الأفكار الناجحة لتطوير العمل.
التنظيم الاداري وأثره على تحقيق التميز المؤسسي: دراسة تطبيقية على شركة عبداللطيف جميل
Authors: الحارثي بدر محمد 
Published: May 2024

هدفت الدراسة إلى بيان أهمية التنظيم الاداري واهدافه ودوافع التميز المؤسسي وكيفية تحقيقه وتوضيح عدة نماذج للتنظيم الاداري وافترضت الدراسة ان هناك علاقة ذات دلاله إحصائية بين التنظيم الاداري وبين التميز المؤسسي وأن هناك علاقه ذات دلاله إحصائية بين عدم التخطيط السليم وبين تحقيق التميز المؤسسي واستخدمت الدراسة طريقة التحليل الإحصائي المتبعة وهي spss لإثبات صحة فرضيات الدراسة ومناقشتها وحساب صدق الاتساق الداخلي لأبعاد المقياس لمحاوره وكذلك مناقشة ثبات أداة الدراسة عن طريق معامل ألفا كرونباخ واستخدام أسلوب (SPSS) عن طريق استخدام اختبار تحليل التباين الأحادي الاتجاه One Way ANOVA على عينة عشوائية وقدرها (50) موظف من العاملين بشركة عبداللطيف جميل بمدينة جدة وتوصلت الدراسة إلى إنه ليست هناك علاقة ذات دلاله إحصائية بين التنظيم الاداري وبين التميز المؤسسي و ان هناك علاقه ذات دلاله إحصائية بين عدم التخطيط السليم وبين تحقيق التميز المؤسسي. كما أوصت الدراسة بضرورة إشراك جميع العاملين في شركة عبداللطيف جميل بدورات تدريبية لاستخدام الحاسوب في أعمالهم.
Reliability and Validity of Visual Estimation in Determining Thorax Rotation Mobility using the Quadruped Lumbar-Locked Position
Authors: Whetstone Katelyn S , Matsel Kyle A , Patton Andrew S , Gehres Sarah E , Schwartzkopf-Phifer Kate 
Published: May 2024

Background Thoracic rotation mobility is crucial for athletes in rotational sports such as baseball, golf, and swimming to maintain the proper biomechanics associated with the sport. Accurate differentiation between normal mobility and active and passive physiological deficits in the thoracic region is critical for identifying the need for intervention to the thorax. Purpose To establish the reliability and discriminant validity of visual estimation of thorax rotation range of motion across clinicians of differing experience levels in determining normal mobility and active or passive physiological deficits when utilizing the quadruped lumbar-locked position. Study Design Cross-sectional Methods Thirty-eight subjects (21 female, 17 male) with a mean age of 27 years ± 6.67 were assessed with the quadruped lumbar-locked thorax rotation test by three examiners with various clinical experience in real-time and again one week later. Bilateral active and passive lumbar-locked thorax rotation mobility was assessed by all raters and categorized as “Unrestricted” (≥50°) or “Restricted” (<50°) while a research assistant simultaneously measured the motion with a digital inclinometer. All raters were blinded to the results. All results were analyzed for intra-rater reliability and agreement. Results Test-retest intra-rater reliability ranged from 0.55-0.72 and percent absolute agreement ranged from 0.82-0.89. Inter-rater reliability ranged from 0.45-0.59 while percent absolute agreement between raters ranged from 0.74-0.84. There was a significant difference in range of motion between “Unrestricted” and “Restricted” categories for both active (Unrestricted=54.6-58.9; Restricted=40.4-44.4; p<0.001) and passive motion (Unrestricted=61.3-63.5; Restricted=39.2-39.7; p<0.001). The only interaction effect was for passive left rotation [Rater A Restricted x ̅ =34.3(30.4-38.2); Rater C Restricted (x ) ̅=43.8(41.3-46.4); p=.000]. Conclusion The quadruped lumbar-locked thorax rotation test demonstrates moderate to substantial test-retest intra-rater and inter-rater reliability regardless of clinical experience. The quadruped lumbar-locked thorax rotation test can accurately discriminate between individuals with active and passive physiological deficits regardless of rater experience using visual estimation. Level of Evidence 3b
Interpersonal Coordination between Female Soccer Players: Leader-Follower Roles within a Collision-Avoidance Task
Authors: Fernandes Courtney A , Norte Grant E , Schwab Sarah M , Gokeler Alli , Murray Amanda , Bazett-Jones David M , Sherman David A 
Published: May 2024

Background/Purpose Return to sport decision-making may be improved by assessing an athlete’s ability to coordinate movement with opponents in sport. The purpose was to investigate whether previous injuries associated with female soccer players’ interpersonal coordination during a collision avoidance task. The authors hypothesized that external perturbations would disrupt the strength and stability of coordinated movement, and that individuals with a history of injury would be less likely to recover coordinated movement. Study Design Cross-Sectional Methods Nine female athletes with a history of lower extremity injuries and nine without injuries were paired into dyads. Each dyad completed twenty trials of an externally paced collision-avoidance agility task with an unanticipated perturbation. Participant trajectories were digitized and analyzed using cross-recurrence quantification analysis (CRQA) to determine the strength and stability of interpersonal coordination dynamics. Trials in which participants with injury history assumed leader or follower roles within each dyad were then used to study how dyadic coordination varied across task stages (early, perturbation, and late) using linear mixed effect models. Cohen’s d effect sizes were calculated to demonstrate magnitude of differences. In exploratory analysis, psychological readiness (i.e., self-reported knee functioning, fear of injury, and risk-taking propensity) was evaluated for their association with leader-follower status. Results Perturbation disrupted the strength (R2=0.65, p<0.001, early=49.7±1.7, perturbation=41.1±1.7, d=0.39) and stability (R2=0.71, p < 0.001, early=65.0±1.6, perturbation=58.0±1.7, d=0.38) of interpersonal coordination regardless of leader-follower status. Individuals with injury history failed to restore coordination after the perturbation compared to control participants (injury=44.2.0±2.1, control=50.8±2.6, d=0.39). Neither demographic nor psychological measures were associated with leader-follower roles (B=0.039, p=0.224). Conclusion Individuals with a history of lower extremity injury may have a diminished ability to adapt interpersonal coordination to perturbations, possibly contributing to a higher risk of re-injury. Level of Evidence 3
Risk Factors Associated with First Time and Recurrent Shoulder Instability: A Systematic Review
Authors: Wright Alexis , Ness Brandon , Spontelli-Gisselman Angela , Gosselin Dora , Cleland Joshua , Wassinger Craig 
Published: May 2024

Background Shoulder instabilities constitute a large proportion of shoulder injuries and have a wide range of presentations. While evidence regarding glenohumeral dislocations and associated risk factors has been reported, less is known regarding the full spectrum of instabilities and their risk factors. Purpose The purpose of this systematic review was to identify modifiable risk factors to guide patient management decisions with regards to implementation of interventions to prevent or reduce the risk of shoulder instability. Study Design Systematic Review Methods A systematic, computerized search of electronic databases (CINAHL, Cochrane, Embase, PubMed, SportDiscus, and Web of Science) was performed. Inclusion criteria were: (1) a diagnosis of shoulder instability (2) the statistical association of at least one risk factor was reported, (3) study designs appropriate for risk factors, (4) written in English, and (5) used an acceptable reference standard for diagnosed shoulder instability. Titles and abstracts were independently screened by at least two reviewers. All reviewers examined the quality studies using the Newcastle-Ottawa Scale (NOS). At least two reviewers independently extracted information and data regarding author, year, study population, study design, criterion standard, and strength of association statistics with risk factors. Results Male sex, participation in sport, hypermobility in males, and glenoid index demonstrated moderate to large risk associated with first time shoulder instability. Male sex, age <30 years, and history of glenohumeral instability with concomitant injury demonstrated moderate to large risk associated with recurrent shoulder instability. Conclusion There may be an opportunity for patient education in particular populations as to their increased risk for suffering shoulder instability, particularly in young males who appear to be at increased risk for recurrent shoulder instability. Level of Evidence Level III
Frequently Associated Problems of Cerebral Palsy
Authors: Malik Bushra Abdul , Zafar Sadia , Razzaq Abdul , Butt Muhammad Asghar , Khan Muhammad Sagheer , Mughal Surriya 
Published: May 2024

Objective To identify the frequently associated problems of cerebral palsy in our setup. Study Design: Descriptive case series. Setting:Department of Pediatrics, Allied Hospital Faisalabad during the period of 2005-2006, Patients and Method: Two hundred children from 1 to 12 years of age of either sex who were diagnosed as cerebral palsy on the basis of history and clinical examination were included and associated problems were identified. Results: Out of 200 cases of CP, the most commonly identified problem was nutritional disorder and growth failure followed by mental retardation, constipation, seizures, contractures, aspiration pneumonia, urinary tract infection, oromotor dysfunctions, visual abnormalities, dental anomalies, hearing abnormalities, scoliosis and behaviour disturbances in that order.
Angiofibroma - a study of 22 cases at Allied Hospital Punjab Medical College, Faisalabad.
Authors: Tirmizey Muhammad Ali , Ahmad Imtiaz , Khan Babar Rafiq , Hanif Muhammad , Saleem Muhammad , Ibrahim Ehsaan 
Published: May 2024

Objective: The Primary objective of the study was to study the presentation of Angiofibroma of Nasopharynx in Faisalabad and to compare the results of various treatment modalities. DESIGN: Prospective comparative study: SETTINGS: The study was carried out at the department of ENT & Head & Neck Surgery Allied Hospital Faisalabad, a tertiary care hospital. PERIOD: June 2001 – June 2006. PATIENTS AND METHODS: A study of 22 cases of Angiofibroma including all cases during the 5 years was carried out. All the patients were admitted. Detailed history, physical examinations, and investigations were done. CT Scan with contrast was done in all cases and in some selected cases, MRI was also done in some cases.RESULTS: All the patients were male between 10 – 25 years of age. All the presented with epistaxis (100%). Other features included, nasal Obstruction, nasal discharge, orbital patients proptosis, mass in the nose and obvious deformity. All the patients underwent surgical excision except two, which were found inoperable. In 3 patients, the tumour was excised by transpalatal approach. In 3 patients, Transnasal – Maxillary approach using Weber Fergusson,s incision was done and in 14 patients, Lateral Rhinotomy was used. CONCLUSIONS: Angiofibroma is a difficult condition to deal with. Any patient with the slightest suspicion must be thoroughly investigated, as early diagnosis makes huge difference in outcome. Surgical excision is the treatment of choice.