bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells
Authors: Bazhin Alexandr V. , De Smet Charles , Golovastova Marina O. , Schmidt Jan , Philippov Pavel P. 
Published: August 2010

Please cite this paper as: Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells. Experimental Dermatology 2010; 19: 1023–1025.Abstract:  The Ca2+‐binding protein recoverin is normally specific for the retina. Recoverin aberrantly expressed in lung and melanoma tumors can trigger the host immune response followed by the development of a paraneoplastic neurological syndrome represented by cancer‐ and melanoma‐associated retinopathy, respectively. The mechanisms, underlying the aberrant expression of recoverin in tumor cells, have remained unknown. The data obtained in this study suggest that (i) DNA methylation participates in the repression of synthesis of mRNA for recoverin in normal tissues and (ii) aberrant hypomethylation of the recoverin gene region, overlapping the promoter up‐stream of the first exon and the first exon itself, is involved in the aberrant expression of recoverin in tumor cells.
Functional interdependence
Authors: Del Aguila Mark , Cox Lisa , Lee Louisa 
Published: August 2010

Objective:  The interrelationship between functional capacity, informal networks and the physical environment of the residence and residential location is used to describe age‐care service utilisation and non‐utilisation. Methods:  Fifty‐two applicants for home‐care services were matched with 52 non‐applicants, and 40 applicants for day‐care services were matched with 40 non‐applicants according to age, gender, mental status, and physical functioning. Results:  Discriminant Function Analyses indicated home‐care applications are related to network isolation within existing neighbourhoods and that day‐care applicant networks were insufficient to accommodate challenges presented by the immediate physical environment of the residence. The physical environment of the residence also distinguished home‐care applicants from day‐care applicants. Conclusion:  The findings support the proposed model of functional interdependence that describes service utilisation and non‐utilisation as a function of the interrelationship between functional capacity and the capacity of family, friends, neighbours and communities of interest to accommodate challenges present in the elder persons residence and residential context.
Validation and reliability of the Modified Elderly Mobility Scale
Authors: Kuys Suzanne S , Brauer Sandra G 
Published: August 2010

Objective:  To establish concurrent validity, interrater and test–retest reliability of the Modified Elderly Mobility Scale (MEMS). Methods:  Ninety elderly patients were scored on the MEMS. To establish concurrent validity, 75 patients MEMS scores were compared to Functional Independence Measure (FIM) scores using Spearman's correlation. Videotaped patient performances were used to establish interrater and test–retest reliability using percentage absolute agreement and intraclass correlation coefficients (ICCs). Results:  The total MEMS score demonstrated a significant association with the motor (r = 0.725) and total FIM scores (r = 0.718). Absolute agreement for interrater reliability was greater than 93% for all test items, with 97 and 98% for the two new measures, respectively. Test–retest reliability demonstrated similar high levels of absolute agreement and had ICCs ranging from 0.870 to 1.0. Conclusions:  The MEMS is a quick, valid and reliable test of motor function of elderly patients with a spread of functional levels.
Older women in Australia: ageing in urban, rural and remote environments
Authors: Byles Julie , Powers Jennifer , Chojenta Catherine , Warner‐Smith Penny 
Published: August 2010

Objective:  To explore differences in quality of life and health service use for older women living in urban, rural and remote areas of Australia. Methods:  8387 women aged 70–75 years when enrolled in the Australian Longitudinal Study on Women's Health completed mailed surveys in 1996, 1999 and 2002. Results:  Women living in urban, rural and remote areas reported few differences in health and had similar changes in health‐related quality of life (SF‐36) over time. Most SF‐36 subscale scores declined over time, with steeper drops between the ages of 73–78 years and 76–81 years. The use of health services, need for informal care and provision of care to others increased over time. Urban participants used more general practitioner, specialist and allied health services, whereas non‐urban women used more community services and alternative health practitioners. Conclusion:  Despite similar health problems, health service use differs significantly across urban, rural and remote areas of Australia.
Treatment of 161 Men with Symptomatic Late Onset Hypogonadism with Long-Acting Parenteral Testosterone Undecanoate: Effects on Body Composition, Lipids, and Psychosexual Complaints
Authors: Permpongkosol Sompol , Tantirangsee Nakorn , Ratana-olarn Krisada 
Published: August 2010

ABSTRACT

Introduction
Elderly men may suffer from late-onset hypogonadism (LOH). The long-term effects of long-acting testosterone undecanoate (TU) in a large number of LOH men have not yet been reported.

Aims
We analyzed the effects of normalization of plasma testosterone (T) in LOH men.

Methods
The records of 161 men with LOH (baseline T &lt; 300 ng/dL) were reviewed and 100 men had used parenteral TU for &gt;12 months. The mean duration of treatment was 90.6 weeks (54 to 150 weeks).

Main Outcome Measures
Body mass index (BMI), waist circumference, percentage body fat, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, prostate-specific antigen (PSA), and hematocrit were measured. Further the Aging Male Symptoms’ scale (AMS) and the International Index of Erectile Function (IIEF-5 and 15) were scored.

Results
T therapy was associated with a significant decline in waist circumference (P = 0.028) and percentage body fat (P &lt; 0.001), but no change of BMI. Total cholesterol and LDL cholesterol declined significantly (P = 0.005 and P = 0.024, respectively), with no significant changes of HDL cholesterol and triglycerides. The scores of sub-scales of AMS (psychological, somotovegetative and sexual factors) decreased (P = 0.044, P = 0.200 and P = 0.071, respectively). The mean IIEF-5 (P = 0.011) and IIEF-15 scores (P = 0.021) improved significantly. Erectile function domain, orgasmic function domain, sexual desire domain, intercourse satisfaction domain, and overall satisfaction domain improved. Median PSA rose from 0.95 (0.640; 1.558) ng/mL to 1.480 (1.015; 2.275) ng/mL (P &lt; 0.001), with 11 patients &gt;4 ng/mL (4.01–13.21). On biopsy there was no evidence for malignancy. The mean hematocrit level increased significantly from 42.3 ± 3.4% to 47.1 ± 3.8%.

Conclusions
Normalizing serum T in men with LOH resulted in improvement of the metabolic syndrome, mood and sexual functions and appeared acceptably safe.
Recurrent Postcoital Hematuria. A Case of Fibroepithelial Urethral Polyp in an Adult Female
Authors: Battaglia Cesare , Battaglia Bruno , Ramacieri Angela , Paradisi Roberto , Venturoli Stefano 
Published: August 2010

ABSTRACT

Introduction
In males, an isolated gross postcoital hematuria is a very rare clinical phenomenon. No cases of postcoital macroscopic hematuria have been previously reported in females.

Aim
To report a case of female urethral fibroepithelial polyp (FEP) associated with recurrent postcoital hematuria.

Methods
A young (31 years old), eumenorrheic woman complained of three episodes of postcoital macrohematuria. The patient was assessed with a detailed history, with a bimanual pelvic examination and with bidimensional and tridimensional ultrasonographic and color Doppler analyses of the internal genitalia and of the urethrovaginal space.

Main Outcomes Measures
Transvaginal two-dimensional (2-D) ultrasonographic evaluation of internal genitalia, bladder and urethra and three-dimensional (3-D) analysis of the urethra and paraurethral structures.

Results
The 2-D transvaginal evaluation and the 3-D reconstruction showed a polypoid hypervascularized structure arising from the anterior urethral wall. A cystourethroscopy confirmed the presence of a FEP arising from the anterior wall of the urethra and allowed its removal.

Conclusions
A gross postcoital hematuria may be associated with a urethral polyp. The ultrasonographic evaluation of the urethrovaginal space can facilitate the diagnosis.
Bladder Perforation Associated with Hot Tub
Authors: Kopp Ryan P. , Dato Paul E. , Sur Roger L. 
Published: August 2010

ABSTRACT

Introduction
Bladder perforation is a rare and life-threatening event. Timely diagnosis may prevent further injury-related morbidity and mortality.

Aim
To present a case of bladder injury associated with masturbation in a hot tub.

Methods
This report describes a case of bladder perforation in a 54-year-old female who presented to the emergency department 2 days after masturbation with a water jet.

Results
Following percutaneous drainage and intraoperative closure of the bladder, the patient was discharged on postoperative day four and has had no sequelae.

Conclusion
Cross-sectional imaging and cystography can facilitate immediate diagnosis and expeditious treatment of bladder injury associated with masturbation in a hot tub.
Role of radiotherapy in solitary bone plasmacytomas
Authors: CHAO Michael W , GIBBS Peter , NORRIS Pam , PRINCE Miles , KIFFER John , FEIGEN Malcolm , QUONG George , WIRTH Andrew , LIEW Kuen‐Hoe 
Published: August 2010

AbstractBackground:  Solitary bone plasmacytoma (SBP) is a rare tumor for which the standard treatment remains local radiotherapy (RT). While this results in high rates of local control, the majority of patients ultimately develop multiple myeloma (MM). Here we present a 20‐year multi‐institutional review of our experience in an attempt to better understand the natural history of SBP and to identify possible prognostic factors.Methods:  A total of 44 patients were identified. The inclusion criteria were the presence of a solitary bone lesion with histologic confirmation of plasma cells on biopsy, a normal bone marrow aspiration and trephine (<10% plasma cells), a negative radiographic skeletal survey, and no anemia, hypercalcemia or renal impairment secondary to plasma cell dyscrasia. Patient ages ranged from 25 to 83 years (median of 54 years) and 64% of patients had a monoclonal paraprotein in the serum and/or urine. All patients received local megavoltage RT with doses ranging from 30 to 54 Gy. Potential prognostic factors including age, gender, site of involvement, presence or absence of soft tissue extension, presence or absence of monoclonal paraprotein at diagnosis, persistence or disappearance of monoclonal paraprotein following RT, the time taken for monoclonal paraprotein to disappear following RT, and the use of magnetic resonance imaging (MRI) staging were evaluated to determine their impact on the likelihood of developing MM.Results:  Median follow up was 6 years (range 0.1–15.2 years). Effective local control was achieved in 42 (95%) patients, but 30 (68%) patients subsequently progressed to MM at a median time to progression of 1.6 years. The median survival from initial diagnosis was 7.5 years. We were unable to define any prognostic factors that were associated with an increased risk of developing MM.Conclusion:  Our series confirms the excellent local control achievable with RT. However, the majority of patients with SBP will ultimately progress to MM and strategies, such as adjuvant chemotherapy, should be explored in selected patients.
Endodontic therapy on a dentition exhibiting multiple periapical radiolucencies associated with dentinal dysplasia Type 1
Authors: Ravanshad Shohreh , Khayat Akbar 
Published: August 2010

AbstractDentinal dysplasia (DD) Type I, is a hereditary disturbance in dentine formation. In this anomaly, teeth in both primary and secondary dentitions are affected, and radiographically show short and blunted roots with obliterated root canals and periapical pathosis. Management of patients with DD has presented dentists with problems. Extraction has been suggested as a treatment alternative for teeth with pulp necrosis and periapical abscess. Follow‐up and routine conservative treatment is another choice of treatment plan in DD. Another approach for the treatment of teeth with DD has included periapical surgery and retrograde filling, which is recommended in the teeth with long roots. The purpose of this report is to present an unusual case of dentinal dysplasia Type I in a 22‐year‐old woman showing upper and lower teeth with obliterated root canals and periapical radiolucencies. In this case, conventional endodontic treatment was performed. Postoperative radiographs and clinical evaluation demonstrated periapical healing and successful results. Based on the results of this case report, conventional endodontic treatment for cases with pulp necrosis and periapical radiolucencies in dentinal dysplasia is highly recommended.
Conservative treatment of patients with periapical lesions associated with extraoral sinus tracts
Authors: Soares Janir Alves , De Carvalho Fabíola Bastos , Pappen Fernanda Geraldes , Araújo Gustavo Sivieri , De Pontes Lima Regina K. , Rodrigues Vivian M. Tellaroli , De Toledo Leonardo Renato 
Published: August 2010

AbstractThis paper describes the clinical courses of three cases with extra‐oral sinus tract formation, from diagnosis and treatment to short‐term follow‐up and evaluation. All teeth involved had periradicular radiolucent areas noted on radiographic examination and extra‐oral sinus tracts appearing on the chin with exudation and unpleasant aesthetic appearance. The adopted treatment protocol included treating the sinus tract surface simultaneously with the root canal therapy. After root canal shaping using 5.25% sodium hypochlorite solution, calcium hydroxide‐based pastes associated with different vehicles were inserted into the root canal for 4 months, and were changed monthly. All the sinus tracts healed in 7 to 10 days. The apical lesions were completely repaired in a maximum period of 24 months. The treatment adopted provided a complete healing of the periapical lesions in a short follow‐up period. Surgical repair of the cutaneous sinus tract was therefore unnecessary.
The importance of ‘approaching’ older people: a grounded theory
Authors: Jonasson Lise‐Lotte , Berterö Carina 
Published: August 2010

jonasson l‐l. & berterö c. (2012) The importance of ‘approaching’ older people: a grounded theory. International Journal of Older People Nursing7, 29–36  doi: 10.1111/j.1748‐3743.2010.00248.xAims and objectives.  The aim of this study was to identify and describe the ethical values in caring encounters as experienced by older patients in their daily interaction with nurses in wards for older people.Background.  Ethical values and morals are important aspects that influence the quality of care.Methods.  Empirical observational study including follow‐up interviews. Twenty‐two older patients participated voluntarily in this study. Constant comparative analysis, the core foundation of grounded theory was used.Results.  Five categories: being addressed, receiving respect, desiring to participate, increasing self‐determination and gaining self‐confidence formed the bases for the core category.Approaching.  Approaching concerns how people become closer to each other in a physical space. It also includes how people become closer to each other in a dialogue, involving verbal or bodily communication.Conclusions and relevance to clinical practice.  Approaching indicates the ethical values that guide nurses in their caring encounters with older patients. These values are noted by the patient and have an individual value as well as leading to improved quality of their care. The older patient will be confident and satisfied with the caring encounter if the desired components in the nurse's approaching are exhibited.
Identification of the Tibetan fox (Vulpes ferrilata) and the red fox (Vulpes vulpes) by copro‐DNA diagnosis
Authors: JIANG WEIBIN , WANG XIAOMING , LI MIN , WANG ZHENGHUAN 
Published: August 2010

AbstractStudies on feeding habits based on faeces dissecting are imperative to understand the natural history of Tibetan foxes and their functions in the transmission of a lethal zoonotic parasite, Echinococcus multilocularis. However, Tibetan foxes and red foxes live sympatrically on the Tibetan plateau, China. Therefore, the faeces of Tibetan foxes must be distinguished from those of red foxes. We established a diagnostic method to distinguish the faeces of the two species by amplifying a portion of the mitochondrial cytochrome b gene (cytb) and digesting with the restriction enzymes BamHI and SspI, to produce specific diagnostic banding patterns. This PCR‐RFLP assay enabled rapid, accurate and easily performed identification and differentiation of the two species.
Detection of species‐specific long VNTRs in mitochondrial control region and their application to identifying sympatric Hong Kong grouper (Epinephelus akaara) and yellow grouper (Epinephelus awoara)
Authors: HAN JIE , LV FENGHUA , CAI HOUCAI 
Published: August 2010

AbstractLength variation and heteroplasmy were observed in PCR products of the first half of mtDNA control region of both Hong Kong grouper (Epinephelus akaara) and yellow grouper (Epinephelus awoara). DNA sequencing unveiled the phenomena were caused by the presence of species‐specific long variable number tandem repeats (VNTRs). This is the first report on the mtDNA VNTRs and their heteroplasmy in groupers. Moreover, these VNTRs are also the longest such structure found in teleost fish. Thereafter, we designed two species‐specific PCR reverse primers according to the 3′ end sequences of the VNTRs and successfully established assays for the identification of these two sympatric grouper species.
Infiltrating macrophages in extratumoural tissues after brachytherapy of uveal melanoma
Authors: Toivonen Päivi , Kivelä Tero 
Published: August 2010

Abstract.Purpose:  To compare distribution of macrophages in extratumoural ocular tissues in enucleated eyes with irradiated and nonirradiated uveal melanomas to find out how irradiation affects distribution of macrophages so as to gain insight into their potential routes of migration and changes in local inflammatory responses.Methods:  Thirty‐four matched pairs of primarily enucleated nonirradiated and secondarily enucleated irradiated eyes with choroidal and ciliary body melanoma were stained with mAb PG‐M1, and the extratumoural immunopositive elements were counted under the microscope. Main outcome variables were the number of macrophages in the sclera underlying the tumour, in the choroid adjacent to the tumour, and in the ciliary body. The number of macrophage aggregates in the anterior ipsi‐ and contralateral episclera adjacent to the limbus was also counted.Results:  Macrophages were more numerous within the sclera under the tumour in irradiated eyes when compared to primarily enucleated eyes (median 1514 versus 619/mm², p = 0.0001), and more aggregates of episcleral macrophages adjacent to the limbus were found after irradiation (ipsilateral side, median 132 versus 0, p = 0.0034; contralateral side, median 79 versus 0, p = 0.014). In primarily enucleated eyes, increasing numbers of tumour‐infiltrating macrophages were associated with presence of higher numbers of macrophages in the ciliary body (p = 0.003) and the adjacent choroid (p = 0.044), whereas in the irradiated eyes, increasing numbers of tumour‐infiltrating macrophages (p = 0.010) and increasing extent of necrosis (p < 0.001) were associated with higher numbers of intrascleral macrophages underlying the tumour.Conclusions:  Resident macrophages are present in extratumoural tissues in eyes with uveal melanoma. Brachytherapy may alter their route of migration and increase the number of macrophages in the sclera and episclera. Histopathologically detectable episcleral aggregates of macrophages adjacent to the limbus are detected predominantly after irradiation, a population of which is clinically visible as episcleral deposits after irradiation.
Is Alcohol Consumption Associated with Male Urinary Incontinence?
Authors: LEE Andy H. , HIRAYAMA Fumi 
Published: August 2010

Objectives: To investigate the association between alcohol consumption and urinary incontinence among Japanese men. Methods: Seven hundred men aged 40–75 years were recruited from the community in middle and southern Japan. A validated food frequency questionnaire was administered face‐to‐face to obtain information on dietary intake and habitual alcohol consumption. Urinary incontinence status was ascertained using the International Consultation on Incontinence Questionnaire‐Short Form. Results: Among the 683 eligible male participants, 49 men (7.2%) experienced urine leakage for the past 2.6 years (standard deviation [SD] 1.9). Their prevalence of alcohol drinking (beer, sake, shochu, wine, whisky) was lower than others without the condition, even though the daily mean ethanol intakes were similar between the two groups, 31.8 g (SD 45.4) and 31.3 g (SD 41.9), respectively. Relative to non‐drinkers, the adjusted odds of urinary incontinence were 0.43 (95% CI 0.19 to 0.96) for low ethanol intake, and up to 32 g per day and 0.53 (95% CI 0.22 to 1.28) for drinking, at most, one can (350 mL) of beer daily. However, higher levels of alcohol consumption had no significant benefit in reducing the incontinence risk. Conclusion: The findings suggested an inverse association between urinary incontinence and low alcohol consumption particularly beer in middle‐aged and older Japanese men.
Endogenous insulin secretion even at a very low level contributes to the stability of blood glucose control in fulminant type 1 diabetes
Authors: Shibasaki Saeko , Imagawa Akihisa , Terasaki Jungo , Hanafusa Toshiaki 
Published: August 2010

AbstractFulminant type 1 diabetes is characterized by almost complete β‐cell destruction, resulting in scarce insulin secretion. In the present study, we aimed to clarify clinical features related to serum C‐peptide levels measured by a high sensitivity method, chemiluminescent enzyme immunoassay, in 12 patients with fulminant type 1 diabetes. Serum C‐peptide was detected (0.007–0.10 nmol/L) in four patients and was not detected in eight patients. A negative correlation was observed between serum C‐peptide levels and daily dosages of insulin (P < 0.01). The patients with detectable C‐peptide showed a significantly lower M‐value than those without (P = 0.01). In conclusion, our present results suggest that even very low levels of endogenous insulin secreting capacity can improve daily dosages of insulin and stabilize blood glucose levels. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2010.0059.x, 2010)