bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a computer study of the reliability of Arabic stories
Authors: Bounhas Ibrahim , Elayeb Bilel , Evrard Fabrice , Slimani Yahya 
Published: May 2010

AbstractThe Arabic storytelling methodology provides solutions to the problem of information reliability. The reliability of a story depends on the credibility of its narrators. To insure reliability verification, the narrators' names are explicitly cited at the head of the story, which constitute its chain of narrators. Stories were reported from a generation to another to insure the reliable transmission of historical knowledge. We present a set of tools based on the Arabic storytelling methodology. We start by presenting this methodology as a set of principles for information‐reliability assessment. Then, we detail an architecture designed to support the study of the reliability of Arabic stories. Indeed, we developed grammars for parsing Arabic full names and chains of narrators of Arabic stories. After that, an intelligent identity recognizer links names found in chains of narrators to the biographies of the corresponding persons. We model this step as a possibilistic information retrieval task. Finally, chains are analyzed through metadata available in biographies to help the user identify sources of unreliability. We propose to identify the class of reliability of a story with a possibilistic classifier. The achieved results in named entity and identity recognition were satisfactory and confirm to the targets set for the precision, recall, and F‐measure metrics. The developed tools also are reusable components that can be used to study the reliability of other types of Arabic texts.
A hyperlink and issue network analysis of the United States Senate: A rediscovery of the Web as a relational and topical medium
Authors: Kim Jang Hyun , Barnett George A. , Park Han Woo 
Published: May 2010

AbstractPoliticians' Web sites have been considered a medium for organizing, mobilizing, and agenda‐setting, but extant literature lacks a systematic approach to interpret the Web sites of senators—a new medium for political communication. This study classifies the role of political Web sites into relational (hyperlinking) and topical (shared‐issues) aspects. The two aspects may be viewed from a social embeddedness perspective and three facets, as K. Foot and S. Schneider (2002) suggested. This study employed network analysis, a set of research procedures for identifying structures in social systems, as the basis of the relations among the system's components rather than the attributes of individuals. Hyperlink and issue data were gathered from the United States Senate Web site and Yahoo. Major findings include: (a) The hyperlinks are more targeted at Democratic senators than at Republicans and are a means of communication for senators and users; (b) the issue network found from the Web is used for discussing public agendas and is more highly utilized by Republican senators; (c) the hyperlink and issue networks are correlated; and (d) social relationships and issue ecologies can be effectively detected by these two networks. The need for further research is addressed.
Synergic effect of retinoic acid and extremely low frequency magnetic field exposure on human neuroblastoma cell line BE(2)C
Authors: Marcantonio Pamela , Del Re Brunella , Franceschini Alessia , Capri Miriam , Lukas Stella , Bersani Ferdinando , Giorgi Gianfranco 
Published: May 2010

AbstractThe aim of the present study was to assess whether exposure to a sinusoidal extremely low frequency magnetic field (ELF‐MF; 50 Hz, 1 mT) can affect proliferation and differentiation in the human neuroblastoma cell line BE(2)C, which is representative of high risk neuroblastomas. Cells were subjected to ELF‐MF exposure in the presence or absence of a neuronal differentiating agent (all‐trans‐retinoic acid, ATRA) for 24–72 h. In each experiment, ELF‐MF‐exposed samples were compared to sham‐exposed samples. Cells exposed to ELF‐MF combined with retinoic treatment showed a decreased cellular proliferation and an increased proportion of G0/G1 phase cells compared to cells exposed to either treatment alone. Moreover, ELF‐MF‐ and ATRA‐treated cells showed more differentiated morphological traits (a higher neurite number/cell, an increased neurite length), together with a significant increase of mRNA levels of p21WAF1/CIP1 and cdk5 genes, both involved in neuronal differentiation. In addition, the expression of cyp19 gene, which is involved both in neuronal differentiation and stress response, was evaluated; cyp19 gene expression was enhanced by ATRA treatment and significantly enhanced further by ELF‐MF exposure combined with ATRA. In conclusion, our data suggest that ELF‐MF exposure can strengthen ATRA effects on neuroblastoma cells. Bioelectromagnetics 31:425–433, 2010. © 2010 Wiley‐Liss, Inc.
Growth characteristics of mung beans and water convolvuluses exposed to 425‐MHz electromagnetic fields
Authors: Jinapang Peeraya , Prakob Panida , Wongwattananard Pongtorn , Islam Naz E. , Kirawanich Phumin 
Published: May 2010

AbstractEffects of high‐frequency, continuous wave (CW) electromagnetic fields on mung beans (Vigna radiata L.) and water convovuluses (Ipomoea aquatica Forssk.) were studied at different growth stages (pre‐sown seed and early seedling). Specifically, the effects of the electromagnetic source's power and duration (defined as power‐duration level) on the growth of the two species were studied. Mung beans and water convolvuluses were exposed to electromagnetic fields inside a specially designed chamber for optimum field absorption, and the responses of the seeds to a constant frequency at various power levels and durations of exposure were monitored. The frequency used in the experiments was 425 MHz, the field strengths were 1 mW, 100 mW, and 10 W, and the exposure durations were 1, 2, and 4 h. Results show that germination enhancement is optimum for the mung beans at 100 mW/1 h power‐duration level, while for water convolvuluses the optimum germination power‐duration level was 1 mW/2 h. When both seed types were exposed at the early sprouting phase with their respective optimum power‐duration levels for optimum seed growth, water convolvuluses showed growth enhancement while mung bean sprouts showed no effects. Water content analysis of the seeds suggests thermal effects only at higher field strength. Bioelectromagnetics 31:519–527, 2010. © 2010 Wiley‐Liss, Inc.
Kinetic characterization of vero cell metabolism in a serum‐free batch culture process
Authors: Petiot Emma , Guedon Emmanuel , Blanchard Fabrice , Gény Cécile , Pinton Hervé , Marc Annie 
Published: May 2010

AbstractA global kinetic study of the central metabolism of Vero cells cultivated in a serum‐free medium is proposed in the present work. Central metabolism including glycolysis, glutaminolysis, and tricarboxylic acid cycle (TCA) was demonstrated to be saturated by high flow rates of consumption of the two major substrates, glucose, and glutamine. Saturation was reavealed by an accumulation of metabolic intermediates and amino acids, by a high production of lactate needed to balance the redox pathway, and by a low participation of the carbon flow to the TCA cycle supply. Different culture conditions were set up to reduce the central metabolism saturation and to better balance the metabolic flow rates between lactate production and energetic pathways. From these culture conditions, substitutions of glutamine by other carbon sources, which have lower transport rates such as asparagine, or pyruvate in order to shunt the glycolysis pathway, were successful to better balance the central metabolism. As a result, an increase of the cell growth with a concomitant decrease of cell death and a better distribution of the carbon flow between TCA cycle and lactate production occurred. We also demonstrated that glutamine was a major carbon source to supply the TCA cycle in Vero cells and that a reduction of lactate production did not necessary improve the efficiency of the Vero cell metabolism. Thus, to adapt the formulation of the medium to the Vero cell needs, it is important to provide carbon substrates inducing a regulated supply of carbon in the TCA cycle either through the glycolysis or through other pathways such as glutaminolysis. Finally, this study allowed to better understand the Vero cell behavior in serum‐free medium which is a valuable help for the implementation of this cell line in serum‐free industrial production processes. Biotechnol. Bioeng. 2010;107: 143–153. © 2010 Wiley Periodicals, Inc.
Efficient expression and purification of human aglycosylated Fcγ receptors in Escherichia coli
Authors: Jung Sang Taek , Kang Tae Hyun , Georgiou George 
Published: May 2010

AbstractEffector Fc gamma receptors (FcγRs) are expressed on the surface of a variety of cells of hematopoietic lineage and serve as a bridge between adaptive and innate immune responses. The interaction between immune complexes, formed by IgG class antibodies that are crosslinked with antigen, and FcγRs triggers signaling cascades that result in numerous cellular responses including the activation or donwregulation of cytotoxic responses, cytokine release, and antibody synthesis. Here, the extracellular domains of the human type I transmembrane FcγRs were expressed in Escherichia coli and their interactions to subclass IgGs (IgG1, IgG2, IgG3, and IgG4) antibodies were analyzed. Expression using fully synthetic E. coli codon optimized FcγR genes and optimization of sequences for N‐terminal translation initiation region through mRNA secondary structure prediction enabled us to achieve high yield of purified, bacterially expressed receptors, including FcγRI and FcγRIIIa which have not been successfully expressed in bacteria until now. The aglycosylated FcγRs showed similar IgG subclass binding selectivity compared to the respective glycosylated FcγRs expressed in mammalian cells. Biotechnol. Bioeng. 2010;107: 21–30. © 2010 Wiley Periodicals, Inc.
Protective effect of binaphthyl diselenide, a synthetic organoselenium compound, on 2‐nitropropane‐induced hepatotoxicity in rats
Authors: Ibrahim Mohammad , Prigol Marina , Hassan Waseem , Nogueira Cristina W. , Rocha Joao B.T. 
Published: May 2010

AbstractOrganoselenides have been documented as promising pharmacological agents against a number of diseases associated with oxidative stress. Here we have investigated, for the first time, the potential antioxidant activity of binaphthyl diselenide ((NapSe)2; 50 mg kg−1, p.o.) against the 2‐nitropropane (2‐NP)‐induced hepatoxicity in rats, using different end points of toxicity (liver histopathology, plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatinine). In addition, in view of the association of oxidative stress with 2‐NP exposure, hepatic lipid peroxidation, ascorbic acid levels, δ‐aminolevulinate dehydratase (δ‐ALA‐D) and catalase (CAT) activities were evaluated. 2‐NP caused an increase of AST, ALT and hepatic lipid peroxidation. 2‐NP also caused hepatic histopathological alterations and δ‐ALA‐D inhibition. (NapSe)2 (50 mg kg−1) prevented 2‐NP‐induced changes in plasmatic ALT and AST activities and also prevented changes in hepatic histology, δ‐ALA‐D and lipid peroxidation. Results presented here indicate that the protective mechanism of (NapSe)2 against 2‐NP hepatotoxicity is possibly linked to its antioxidant activity. Copyright © 2010 John Wiley & Sons, Ltd.
Direct and indirect effects of kisspeptin on liver oxidant and antioxidant systems in young male rats
Authors: Aydin M. , Oktar S. , Yonden Z. , Ozturk O. H. , Yilmaz B. 
Published: May 2010

AbstractKisspeptin is a recently discovered hypothalamic peptide which plays an important role in the central control of reproductive functions. We have investigated direct and indirect effects of kisspeptin on the liver oxidative stress in young male rats. Twenty‐four rats were divided into four groups (n = 6/group). First group served as control and received saline. Kisspeptin‐10 was administered to the animals in the second group (20 nmol/rat/day), for a period of 7 days. Rats were given only one dose gosereline (0.9 mg/rat), a GnRH agonist in the third group. The last group received kisspeptin‐10 with gosereline. The activities of catalase, superoxide dismutase (SOD), xanthine oxidase (XO), adenosine deaminase (AD) and level of malondialdehyde were studied in liver tissue. Serum samples were separated for total antioxidant capacity (TAC), total oxidant status (TOS), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, blood urea nitrogen (BUN), colesterol, high‐density lipoprotein (HDL) and triglyceride. Kisspeptin increased the activities of SOD and catalase (p < 0.05). When compared to the control group, the levels of malondialdehyde, TOS and AST were lower, but levels of BUN, cholesterole, HDL and AD were higher in the other three groups (p < 0.05). In conclusion, our findings suggest that kisspeptin may have antioxidant and thus protective effects on the liver tissue. Copyright © 2010 John Wiley & Sons, Ltd.
Oral vitamin C and E combination modulates blood lipid peroxidation and antioxidant vitamin levels in maximal exercising basketball players
Authors: Nazıroğlu Mustafa , Kılınç Fatih , Uğuz Abdulhadi Cihangir , Çelik Ömer , Bal Ramazan , Butterworth Peter J. , Baydar Metin Lütfi 
Published: May 2010

AbstractOxidative stress occurs during maximal exercise, perhaps as a result of increased consumption of oxygen. Vitamins C and E can overcome the effects of antioxidants in exercise. We investigated the effects of supplementation with a combination of vitamin C and E (VCE) on blood lipid peroxidation (LP) and antioxidant levels following maximal training in basketball players.Blood samples were taken from 14 players (group A) and divided into two subgroups namely maximal training (group B) and maximal training plus VCE groups (group C). Group B maximally exercised for 35 days. VCE was supplemented to group C for 35 days and blood samples were taken from group B and C. Plasma and hemolyzed erythrocyte samples were obtained from the players.Erythrocyte glutathione peroxidase (GSH‐Px) activity and plasma vitamin E concentration were lower in group B than in group A, whereas plasma and erythrocyte LP levels were higher in group B than in group A. Plasma vitamin A, vitamin E, erythrocyte GSH‐Px, and reduced glutathione (GSH) values were higher in group C than in groups A and B although LP levels in plasma and erythrocytes were lower in group C than in group A and B. β‐Carotene values did not change in the three groups.In conclusion, VCE supplementation in maximal exercising basketball players may strengthen the antioxidant defense system by decreasing reactive oxygen species (ROS). Copyright © 2010 John Wiley & Sons, Ltd.
Development of magnetic chromatography to sort polydisperse nanoparticles in ferrofluids
Authors: Forge Delphine , Gossuin Yves , Roch Alain , Laurent Sophie , Elst Luce Vander , Muller Robert N. 
Published: May 2010

AbstractWhatever the strategy of synthesis, nanoparticles in magnetic fluids commonly feature a broad size distribution. However, the presence of several size populations in ferrofluids is often problematic because of the close relationship between the efficiency of the nanoparticles and their physicochemical properties. In this work, a magnetic size sorting procedure is developed in order to reduce this polydispersity, using the magnetic properties of the iron oxide nanoparticles. This magnetic sorting with an adjustable magnetic field allows isolation of the small superparamagnetic particles as well as the larger particles. Magnetometry, nuclear magnetic relaxation dispersion profiles and transmission electron microscopy were successfully used to check the efficiency of the magnetic sorting procedure, which was shown to work as a ‘magnetic’ chromatography. Copyright © 2010 John Wiley & Sons, Ltd.
Stress analysis of first permanent mandibular molar with class 1 restorations of different cement bases by occlusive load: A finite element analysis
Authors: Liu Zhan , Qian Yingli , Liu Dan , Yang Jinbo , Fan Yubo 
Published: May 2010

AbstractIt was the aim of the study to analyze stress distribution in tooth and restoration by occlusal load of Class I. Comparative analysis was used to evaluate effects of four kinds of cement bases on the stresses in resin composite restorations. The elastic moduli and Poisson's ratios of the three kinds of restorative materials were tested. Micro‐CT was used to scan the first mandibular molar, and the three‐dimensional finite element model of the tooth with class I cavity was built by ABAQUS. Occlusive load of 250N was applied on the model. Then von Mises stresses distribution in the enamel, dentin, resin composite and bases were analyzed by occlusive loading of different cement bases. As single‐layer base, the maximum von Mises stresses of the enamel and the dentin of the Dycal base were much lower than those of the VIT base. As double‐layer base, the maximum von Mises stresses of the enamel and the dentin of VIT and Dycal were much higher than those of VIT and Ultra‐blend plus. Cement bases should have a high elastic modulus in order to reduce the stress of the enamel and the dentin. The present study would help clinicians to make an informed choice of the cement bases to avoid the fracture of tooth or restoration. Copyright © 2010 John Wiley & Sons, Ltd.
P38 mitogen‐activated protein kinase signal transduction in the diagnosis and follow up of immunotherapy of wasp venom allergy
Authors: Verweij Marjoke M. , De Knop Kathleen J. , Bridts Chris H. , De Clerck Luc S. , Stevens Wim J. , Ebo Didier G. 
Published: May 2010

AbstractBackground:P38 mitogen‐activated protein kinase (MAPK) is known to govern IgE‐mediated basophil activation. Intracellular phosphorylated p38 MAPK (Pp38 MAPK) in IgE‐activated basophils can be quantified flow cytometrically.Objectives:To study whether Pp38 MAPK constitutes a potential novel read‐out for flow‐assisted diagnosis of hymenoptera venom allergy and to investigate whether this marker allows follow‐up of successful venom immunotherapy (VIT).Methods:Fifty‐two patients with documented wasp venom allergy and seven wasp‐stung asymptomatic control individuals were enrolled. Wasp venom‐induced basophil activation was analyzed flow cytometrically with anti‐IgE, anti‐CD63, and anti‐Pp38 MAPK to assess their activation status before starting immunotherapy. To assess whether p38 MAPK constitutes a candidate marker for monitoring VIT, we repeated the basophil activation test (BAT) in 25 patients on the fifth day of a build‐up immunotherapy. In addition, we investigated whether the Pp38 MAPK‐based BAT could contribute in the decision of discontinuing VIT in a cross‐sectional analysis in 13 patients receiving treatment for 3 years and 14 patients receiving treatment for 5 years.Results:Patients exhibited a dose‐dependent basophil activation with phosphorylation of p38 MAPK and upregulation of downstream CD63. In contrast, stung controls demonstrated a dose‐dependent but “abrogated” signal transduction in basophils with less and shorter duration of the phosphorylation of p38 MAPK and without subsequent upregulation of CD63. When repeated after 5 days of VIT and when investigated cross‐sectionally after 3 years or 5 years of maintenance therapy, no effect of VIT on the phosphorylation of p38 MAPK was demonstrable.Conclusions:This study discloses that not only basophils from patients, but also from the stung control individuals, respond to wasp venom stimulation with phosphorylation of p38 MAPK, although to a lesser extend. No clear effect of VIT on the phosphorylation of p38 MAPK was shown. Thus, although p38 MAPK provides an additional tool in the diagnosis of wasp venom allergy, it does not contribute to the decision whether to stop successful VIT. © 2010 International Clinical Cytometry Society
Dietary supplement use immediately before and during pregnancy in Norwegian women with eating disorders
Authors: Dellava Jocilyn E. , Von Holle Ann , Torgersen Leila , Reichborn‐Kjennerud Ted , Haugen Margaretha , Meltzer Helle M. , Bulik Cynthia M. 
Published: May 2010

AbstractObjective:Many pregnant women use dietary supplements. Little is known about dietary supplement use during pregnancy in women with eating disorders.Method:We examined dietary supplement use in 37,307 pregnant women, from the Norwegian Mother and Child Cohort Study.Results:Dietary supplement use during pregnancy was as follows: 91.2% of women with anorexia nervosa, 92.2% of women with bulimia nervosa, 93.2% of women with eating disorder not otherwise specified‐purging subtype (EDNOS‐P), 90.6% of women with binge eating disorder, and 93.5% of the women without eating disorders. Between group differences were not statistically significant. After adjusting for covariates, women with EDNOS‐P were more likely to take iron containing supplements (p ≤ .04).Discussion:Overall dietary supplement use in this sample is similar in women with and without eating disorders. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:325–332)
A prospective test of the relation between weight change and risk for bulimia nervosa
Authors: Thomas J. Graham , Butryn Meghan L. , Stice Eric , Lowe Michael R. 
Published: May 2010

AbstractObjective:Prospectively investigate whether weight gain or weight loss increases risk for onset of binge eating and purging in adolescent women.Method:Diagnostic interviews and direct measures of body mass were completed by 496 adolescent women annually for 8 years.Results:Substantial weight gain or weight loss during the study produced a sevenfold increase in risk for future onset of threshold or subthreshold bulimia nervosa (BN) relative to weight‐stable participants, though the low incidence rate limited statistical power. Those who showed onset of threshold/subthreshold BN experienced greater increases in weight in the 2 years before onset of their eating disorder relative to healthy comparison participants.Discussion:This is the first prospective study to demonstrate that weight gain and weight loss may both increase risk for future onset of bulimic pathology. Results suggest that young women who have difficulty limiting their dietary intake are at increased risk for BN, an eating disorder characterized by loss of control over eating. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:295–303)
Effects of acute alcohol intoxication on eating‐related urges among women with bulimia nervosa
Authors: Bruce Kenneth R. , Steiger Howard , Israel Mimi , Kin N.M.K. Ng Ying , Hakim Julie , Schwartz Diana , Richardson Jodie , Mansour Sandra A. 
Published: May 2010

AbstractObjective:To investigate the effects of acute alcohol intoxication on eating‐related urges among women with bulimia nervosa (BN).Method:Participants included women with BN or normal‐weight eating disorder NOS with regular binge/purge symptoms (N = 13), and normal‐eater control women (N = 17). Tested individually, the women reported on their mood state as well as on urges to binge eat and engage in various compensatory behaviors, prior to consuming alcohol, and again at 60 and 180 min following the consumption of 1.0 ml kg−1 alcohol.Results:Both groups reported feeling less clearheaded after drinking, as well as initial subjective mood stimulation followed by subsequent mood lowering. In addition, BN participants reported reductions in their urges to binge eat, exercise compulsively, and restrict food intake following alcohol consumption—the urge to purge was not significantly affected.Discussion:Among women with BN, alcohol consumption appeared to reduce select eating‐related urges with concomitant reductions in attention or concentration. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011; 44:333–339)