bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and economic implications of using daratumubab with lenalidomide in the 1st and 2nd lines of therapy for multiple myeloma patients
Authors: Ivakhnenko О. I. , Ryazhenov V. V. , Falaleeva N. A. 
Published: May 2024

Objective: to assess clinical and economic implications of adding daratumumab (Dara) to the “lenalidomide + dexamethasone” (Rd) treatment program in early lines of therapy for patients with multiple myeloma (MM) ineligible for high-dose chemotherapy (HDCT) with subsequent autologous hematopoietic stem cell transplantation (autoHPSCT).Material and methods. Partitioned survival model was developed to compare overall survival in the treatment programs of MM patients in the 1st to 3rd lines of therapy. The following treatment options were included in the analysis: 1st line – Dara+Rd; 2nd line – “carfilzomib + lenalidomide” (K+Rd) or “ixazomib + lenalidomide” (Ixa+Rd) triplets; 3rd line – pomalidomide (Pom+dex) and Rd+(Dara+Rd)+(Pom+dex) versus Rd+(K/Ixa+Rd)+(Pom+dex/Dara). Probabilities of transition between health states (progression-free, progressed disease, and death) were based on published clinical data. Lifetime direct healthcare costs and incremental cost-effectiveness ratios (ICERs) per 1 life year gained were calculated from a Russian health care perspective. The indicator of the difference in costs between current and expected practice was used in budget impact analysis.Results. Dara+Rd combination increased life expectancy by 1.04 years (+16.05%) and 0.95 years (+14.57%) per patient, and in the target population (n=955) by 995.48 and 903.40 years for (Dara+Rd)+(K+Rd)+(Pom+dex) and (Dara+Rd)+(Ixa+Rd)+(Pom+dex) treatment programs, respectively, compared to Rd use in the 1st line. The ICER per 1 life year gained for Dara+Rd in 1st line therapy was 8.95 mln rubles for (Dara+Rd)+(K+Rd)+(Pom+dex) and 8.41 mln rubles for (Dara+Rd)+(Ixa+Rd)+(Pom+dex). It's lower than the median ICER of 13.64 million per 1 life year gained for antitumor drugs used to treat cancer of lymphatic and hematopoietic tissues (reference ICER). Dara+Rd triplet is used in 2nd line therapy after Rd, the number of life years gained in the target population due to greater efficacy is higher by 291.50 years compared with K+Rd and by 203.93 years compared with Ixa+Rd. The ICER per 1 life year gained for Dara+Rd is also lower than the ICER reference value: 9.25 mln rubles versus 13.64 mln rubles. The budget impact analysis showed that using Dara in early stages of MM therapy does not increase drug provision costs in the target population.Conclusion. The obtained results allowed to conclude that it is economically feasible to add Dara to the 1st and 2nd lines of therapy in lenalidomide treatment programs for MM patients who are not candidates for HDCT with autoHPSCT.
История России и СССР как стихия и заговор
Authors: Ильинский Игорь Михайлович 
Published: May 2024

<p>Данный текст продолжает тему предыдущих статей И. М. Ильинского, опубликованных в журнале «Знание. Понимание. Умение» и посвященных пониманию перестройки как заговора. В настоящей статье автор исследует роль заговора как такового против монархического режима в поздней Российской империи, затем в раннем СССР, потом в период сталинских реформ и в эпоху перестройки. Особое внимание уделяется опыту сталинской модернизации: на материале новейших исторических исследований показывается, что расхожая точка зрения на Сталина как тирана, движимого исключительно стремлением к власти, в корне не верна. Как считает И. М. Ильинский, Сталин был выдающимся государственным деятелем, стремившимся провести действительно необходимые стране реформы — демократизацию политической системы, построение мощного индустриального и военно-промышленного комплекса. При этом руководитель Советского государства сталкивался с мощным противодействием планам своих преобразований со стороны различных групп советской элиты. Это противодействие, как показано в статье, нередко принимало характер откровенного заговора.</p><p>Автор весьма критически оценивает деятельность последующих руководителей СССР — Н. С. Хрущева и в особенности М. С. Горбачева — последний, с его точки зрения, осуществил масштабную контрреволюцию, которая привела в итоге к распаду СССР.</p><div> </div>
Общественные ресурсы и технологии для контактной работы власти с населением
Authors: Островский Антон Николаевич , Шахов Вадим Сергеевич 
Published: May 2024

<p>Целью исследования явились типологизация групп граждан в зависимости от характера их социальной активности и определение превалирующих методов работы власти с каждой из групп; выделение нишевой целевой группы для возможного применения технологий соучастия граждан в принятии решений, касающихся перспектив развития территорий, реализуемых с привлечением посредника-медиатора.</p><p>Статья представляет результаты онлайн-опроса 384 жителей одного из городских округов ЦФО РФ — участников местных онлайн-сообществ, проведенного в 2019–2023 гг. Результаты исследования позволили классифицировать горожан на три условные группы в зависимости от степени их готовности к тем или иным формам активизма; определить ключевые механизмы работы с различными категориями граждан в онлайн- и офлайн-форматах. </p><p>Доля граждан, готовая к форматам очного взаимодействия с администрацией, представлена 6% лиц, ранее имевших подобный опыт; 14,2% респондентов, подтвердивших свое согласие на участие в публичных слушаниях / общественных обсуждениях, а также 38,8% тех, кто готов участвовать в названных выше мероприятиях исключительно в свободное время.</p><p>Полученные результаты свидетельствуют о существующем запросе населения на участие в принятии решений, касающихся дальнейшего развития территорий в формате очного режима публичных слушаний и общественных обсуждений, проводимых по стандартам соучаствующего проектирования с применением медиативных технологий. </p>
Актуализация культурного наследия в молодежной среде (на примере Республики Корея)
Authors: Миронова Татьяна Николаевна 
Published: May 2024

<p>Статья посвящена исследованию проблемы сохранения и использования культурного наследия в молодежной среде на примере Республики Корея.</p><p>Недостаточное внимание к содержанию потребляемой культурной продукции может изменять нравственные ценности и духовные ориентиры, формирующие мировоззрение граждан. В то же время важно не только защищать свои национальные ценности и суверенитет, но и предлагать свою культуру другим странам, так как с помощью культурной дипломатии иногда можно добиться большего влияния, чем с помощью политических, экономических мер или даже военных сил.</p><p>Наиболее успешный пример эффективной культурной политики по продвижению традиционных ценностей среди молодежи — Республика Корея. Начиная с 2000-х гг. Корея выстраивает целенаправленную политику, получившую название «корейская волна». Ее успех обусловлен целым рядом факторов, которые рассматриваются автором данной статьи. </p>
ICC Jurisdiction: Against Israeli War and Humanitarian Crimes Targeting Palestinian Civilians 2023
Authors: Soraya Ninda , Muhammad Ali , Ladiqi Suyatno 
Published: May 2024

The article explains the jurisdictional policy of the International Criminal Court (ICC) regarding Israeli war crimes targeting Palestinian civilians, during the attack on Gaza on October 7, 2023. The article shows that based on articles of the Rome Statute, Israel committed war crimes and crimes against humanity that occurred on October 7, 2023. therefore, the ICC has authority in this matter. ICC policy towards conflict 7 October 2023, ICC jurisdiction took action to continue the investigative process and will accelerate investigations related to the conflict, while Israel in 2024 and the latest update is not part of the non-member states of the ICC. However, given the jurisdiction of the ICC, it has jurisdiction regarding its investigations in countries that are not parties to the ICC. This is influenced by several factors in upholding the ICC's jurisdictional investigation law against Israeli criminals even though Israel is not an ICC member state: First, Palestine is a state party to the ICC which is supposed to provide justice for civil society. Second, there is pressure and encouragement from member countries and non-member countries of the ICC to carry out investigations regarding the conflict attack in October 2023.
Assessment of immunohistochemical expression of trophoblast cell surface antigen 2 (Trop 2) in oral squamous cell carcinoma and its clinicopathological correlation
Authors: Kaushal Nidhi , Mandale Mandakini S , Humbe Jayanti G , Nandkhedkar Vaishali Anil , Wagh Savita Prashant , Pachpande Priyanka S 
Published: May 2024

Trophoblast cell surface antigen 2 (Trop 2) is a transmembrane glycoprotein that is involved in a variety of oncogenic cell signaling pathways. Its heterogeneous expression in normal and cancerous tissues makes it a diagnostic and prognostic marker for various malignancies, including Oral Squamous Cell Carcinoma (OSCC). To assess the immunohistochemical expression of Trop 2 in OSCC and evaluate its clinicopathological correlation. Histopathologically diagnosed 40 cases of OSCC and their respective clinical records were retrieved and subsequent clinical staging and histopathological grading was done. Formalin fixed parrafin embedded sections were subjected to immunohistochemistry with anti Trop 2 antibody using standard DAB technique. The immunohistochemical expression of Trop 2 was evaluated using immunostaining intensity and mean integrated score followed by its comparison with age, gender, anatomical site, clinical stages and histopathological grades of OSCCTrop 2 expression was positive in 97.5% of cases. There was a statistically significant difference (p value&#60;0.001) between immunostaining intensity and integrated score of Trop 2 among various histopathological grades of OSCC. As grade of OSCC increased, integrated score decreased. Trop 2 is one of the biomarkers that may serve as a useful tool to detect the changes undergoing at the molecular level which have prognostic or therapeutic significance.
Histopathological study of lungs, kidney and spleen in death due to burns
Authors: Nayaka Nandini S , Nayaka Gajanan H , N Malini 
Published: May 2024

Burn injuries occur universally and have plagued mankind ever since antiquity till the present day. As burns continue to be a major problem, a prospective study of demographic and pathological profile in deaths due to burns was conducted at the Department of Pathology Karnataka Institute of Medical Sciences Hubballi. To study the demographic profile, histopathological changes in lungs, kidney and spleen and to find the cause of death in cases due to burns. : The present study was carried out in the Department of Pathology, Karnataka institute of medical sciences, Hubballi, during the period of one year from 1-11-2014 to 31-10-2015. Total of 44 cases with burn injuries were used as material for study purpose and the collection of tissues were done for histopathology examination. This study includes 44 autopsy cases of death due to burn, of which majority were females. The age of the subjects ranged from 13 years to 65 years. Maximum numbers of victims were found in the age group of 21-30 years were 22 cases (50.00%).Most of the female victims were married and housewives. Most common manner of the burn were said accidental burns in 27 cases (61.36%) and 13 cases (29.54%) were due to suicidal burns, 4 cases (9.09%) were homicidal burns.Burns were more common in females most were married. Age group most commonly found was between 21-30 years of age probably related to dowry related issues, inexperience in cooking styles, house hold works, and inability to bear stress. Most common place of burns were kitchen. Most common manner of burns were said accidental. Most common cause of burns was due to said kerosene spill over or self pouring. TBSA involved more than 76%, in maximum number of cases. Maximum finding were seen in lung. Most common findings were diffuse alveolar damage, acute tubular injury and congested splenomegaly.
A case of diabetic mastopathy: An unusual breast lesion mimicking cancer in type 1 diabetes mellitus
Authors: Joseph Sheethal Joseph , Sekar Manjani , Srirangaramasamy Jamunarani , Rahim Rejla 
Published: May 2024

Diabetic mastopathy is a rare fibroinflammatory disorder seen among middle aged and premenopausal age group. It is also called lymphocytic mastopathy or sclerosing lymphocytic mastitis. This is seen associated with type 1 diabetes mellitus and other autoimmune disorders specially related to endocrine disorders like thyroid. The definite diagnosis of diabetic mastopathy is truly based on biopsy and histopathological examination.A 33 year old female came to hospital with complaints of swelling in right breast since one month and pain since one week. She was a known case of type 1 diabetes mellitus since 10 years and on regular medications. Radiological Impression was possibilities of mastitis with abscess formation more likely to be considered. But infiltrating malignant neoplasm with areas of necrosis is also a differential diagnosis. Our histopathology laboratory, we received incision biopsy from right breast and microscopic examination from multiple tissue sections showed breast parenchyma with extensive fibrosis and periductal inflammatory infiltrate predominantly lymphocytes, plasma cells and a few neutrophils. Some of the ducts show epithelial proliferation forming bridges and micropapillae. Histopathological diagnosis was Lymphocytic Mastitis with features of Atypical Ductal Hyperplasia.: The diagnosis of Diabetic Mastopathy is based on clinical details, radiological evaluation and biopsy correlation. Sometimes it’s difficult to differentiate from carcinoma breast, so histopathological examination is indicated for a definitive diagnosis and management.
COMPARATIVE CHARACTERISTICS OF METHODS OF IMMOBILIZATION OF FRAGMENTS IN FRACTURES LOWER JAW
Authors: Soltanov Sahil , Ksembaev Said , Ivanov Oleg , Salahov Albert , Nesterova Elena , Gabidullina Guzel 
Published: May 2024

Item. A review of the literature is presented on the current problem of maxillofacial surgery – methods of fixation of bone fragments in fractures of the lower jaw.
The purpose of the study is to study publications on methods of fixation of fragments in fractures of the lower jaw in the comparative aspect of their influence on the clinical course.
Methodology. The publications of domestic and foreign authors on modern methods of fixation of bone fragments in fractures of the lower jaw were studied, and a comparative analysis of their effectiveness was carried out.
Results. Currently, orthopedic and surgical methods of immobilization of bone fragments are used, which are used both in isolation and in various combinations. During surgical treatment with the help of mini-plates, it is possible to perform optimal reposition and stable fixation of fragments, however, the traumatic nature of the operation, leading to bone hypoxia, slows down the processes of reparative osteogenesis and leads to the development of postoperative complications. The use of bone glue-cement makes it possible to achieve reliable fixation of bone fragments, accelerate the formation of a callus. At the same time, there is no need to remove the glue, since it is a biodegradable material.
Conclusions
1.	None of the currently used methods of fixation of bone fragments in clinical practice for fractures of the mandible, both orthopedic and surgical, as well as in their combination, can fully meet the optimal conditions of reparative osteogenesis.
2.	A promising alternative method is the use of bone adhesives that fill the bone voids between fragments, which contributes to their stable fixation and reparative osteogenesis, biodegrading simultaneously with the formation of a callus.
CONTINUIDADE DAS ATIVIDADES EXTENSIONISTAS EM TEMPOS DE PANDEMIA:
Authors: Soares Sebastião Silva , MOURA ARAUJO LEILIANE MOURA , Gama Brito Roberta , Gonçalves da Silva Fonseca Eliana 
Published: May 2024

Este artigo tem por objetivo apresentar os dados do projeto de extensão ‘Café científico: vamos falar de ciência?’ realizado na Universidade Federal do Tocantins (UFT) – Campus Arraias. O projeto teve como propósito oferecer aos participantes mecanismos de compreensão de iniciação à metodologia da pesquisa, no sentido de beneficiar os processos de estudos e pesquisas durante a graduação e a formação de novos pesquisadores por parte dos professores nas escolas e universidades, principalmente no contexto de pandemia da covid-19. Cada ação possibilitou a troca de conhecimento e formação de saberes, como também a formação de redes de pesquisadores e de iniciação científica. O processo de transpor os diálogos vivenciados pelo grupo para o canal do Youtube ampliou o interesse deste por novas reflexões em torno das questões sobre ciência, tecnologia e metodologia científica.
PALAVRAS-CHAVE: Extensão Universitária. Covid-19. Conhecimento Científico. Metodologia da Pesquisa.
Are Orthopaedic Clinical Trials Linguistically and Culturally Diverse?
Authors: Julian Kaitlyn R. , Mulakaluri Ashley , Truong Nicole M. , Fernandez Alicia , Kamal Robin N. , Shapiro Lauren M. 
Published: May 2024

Background:
Underrepresentation and misrepresentation of historically underrepresented populations in randomized controlled trials (RCTs) may have implications for the validity of research results and their application to diverse populations. The purpose of this study was to evaluate the representation of historically linguistically, racially, and ethnically underrepresented participants in orthopaedic RCTs and to assess the use of translated and culturally adapted patient-reported outcome measures (PROMs).

Methods:
Separate and comprehensive literature searches of PubMed, Web of Science, and Embase databases were performed to identify RCTs using PROMs between 2012 and 2022 among the top 5 highest 5-year impact factor orthopaedic journals according to the 2021 Journal Citation Reports database. The primary outcomes of interest included reporting of linguistic, racial, and ethnic demographic characteristics of trial participants and the utilization of translated PROMs. The methodological quality of each clinical trial was assessed using the Jadad Criteria.

Results:
A total of 230 RCTs met inclusion criteria. The language of participants was reported in 14% of trials and in 17% of trials when searching both the published text and clinical trial registration information. In addition, race and/or ethnicity was reported in 11% of trials, and the use of translated PROMs was reported in 7% of trials. Among the 6 multinational studies, none reported the language of the study population, nor the use of translated PROMs. Notably, 4 studies (2%) reported using culturally adapted PROMs. The average Jadad score was 3.07.

Conclusion:
Participant language, race, and ethnicity are infrequently reported in orthopaedic clinical trials, potentially limiting the application and interpretation of study results. Similarly, the linguistic and cultural adaptation of PROMs used is often not reported, which also limits interpretations of the validity and generalizability of orthopedic study results. Researchers and journals should promote standard reporting of demographic data and methods of PROM adaptation to ensure that results are generalizable to diverse patient populations.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
User Preferences and Needs for Health Data Collection Using Research Electronic Data Capture: Survey Study
Authors: Soni Hiral , Ivanova Julia , Wilczewski Hattie , Ong Triton , Ross J Nalubega , Bailey Alexandra , Cummins Mollie , Barrera Janelle , Bunnell Brian , Welch Brandon 
Published: May 2024

Background
Self-administered web-based questionnaires are widely used to collect health data from patients and clinical research participants. REDCap (Research Electronic Data Capture; Vanderbilt University) is a global, secure web application for building and managing electronic data capture. Unfortunately, stakeholder needs and preferences of electronic data collection via REDCap have rarely been studied.

Objective
This study aims to survey REDCap researchers and administrators to assess their experience with REDCap, especially their perspectives on the advantages, challenges, and suggestions for the enhancement of REDCap as a data collection tool.

Methods
We conducted a web-based survey with representatives of REDCap member organizations in the United States. The survey captured information on respondent demographics, quality of patient-reported data collected via REDCap, patient experience of data collection with REDCap, and open-ended questions focusing on the advantages, challenges, and suggestions to enhance REDCap’s data collection experience. Descriptive and inferential analysis measures were used to analyze quantitative data. Thematic analysis was used to analyze open-ended responses focusing on the advantages, disadvantages, and enhancements in data collection experience.

Results
A total of 207 respondents completed the survey. Respondents strongly agreed or agreed that the data collected via REDCap are accurate (188/207, 90.8%), reliable (182/207, 87.9%), and complete (166/207, 80.2%). More than half of respondents strongly agreed or agreed that patients find REDCap easy to use (165/207, 79.7%), could successfully complete tasks without help (151/207, 72.9%), and could do so in a timely manner (163/207, 78.7%). Thematic analysis of open-ended responses yielded 8 major themes: survey development, user experience, survey distribution, survey results, training and support, technology, security, and platform features. The user experience category included more than half of the advantage codes (307/594, 51.7% of codes); meanwhile, respondents reported higher challenges in survey development (169/516, 32.8% of codes), also suggesting the highest enhancement suggestions for the category (162/439, 36.9% of codes).

Conclusions
Respondents indicated that REDCap is a valued, low-cost, secure resource for clinical research data collection. REDCap’s data collection experience was generally positive among clinical research and care staff members and patients. However, with the advancements in data collection technologies and the availability of modern, intuitive, and mobile-friendly data collection interfaces, there is a critical opportunity to enhance the REDCap experience to meet the needs of researchers and patients.