bluuebunny/crossref_metadata_2025_split huggingface dataset:
THREE NEW CECIDOMYIID FLIES
Authors: Cockerell T. D. A. 
Published: February 2010

Near Monument Creek, Colorado Spirngs, my wife and I recently came across an undetermined species of Artemisia, about three feet high, bearing many Cecidomyiid galls. The flies emerged these galls on April 2, and as the species is new, it is herewith described:Diplosis Coloradella n. sp.—♂. Length hardly 2 mm. Head black; thorax black, reddish posteriorly mesothorax with rows of black bristles; legs reddish-brown, suffused with dusky; abdomen narrow, reddish passing into yellowish, with long lateral hairs, genitalia darker, terminal joint of forceps stout; wings with a very long fringe; first vein reaching costa about or very slightly below middle of wing; third vein reaching the margin at the apex of the wing, but the apex is subtruncate, rather bulging below, so that the most distal point seems a little below the end of the vein; fifth vein forked beyond its middle, but its distal half reduced to mere shadowy lines; antennæ reddish, 15 (2+13) jointed, joints cylindrical, slightly constricted in the middle, pedicillate with very long hairs, terminal joint subacuminate.
Differential Geminin Requirement for Proliferation of Thymocytes and Mature T Cells
Authors: Karamitros Dimitris , Kotantaki Panorea , Lygerou Zoi , Veiga-Fernandes Henrique , Pachnis Vassilis , Kioussis Dimitris , Taraviras Stavros 
Published: January 2010

Abstract
Stem/progenitor cells coordinate proliferation and differentiation, giving rise to appropriate cell numbers of functionally specialized cells during organogenesis. In different experimental systems, Geminin was shown to maintain progenitor cells and participate in fate determination decisions and organogenesis. Although the exact mechanisms are unclear, Geminin has been postulated to influence proliferation versus differentiation decisions. To gain insight into the in vivo role of Geminin in progenitor cell division and differentiation, we have generated mice that specifically lack Geminin in cells of lymphoid lineage through Cre-mediated recombination. T cells lacking Geminin expression upregulate early activation markers efficiently upon TCR stimulation in vitro and are able to enter the S phase of cell cycle, but show a marked defect in completing the cycle, leading to a large proportion of T cells accumulating in S/G2/M phases. Accordingly, T cells deficient in Geminin show a reduced ability to repopulate lymphopenic hosts in vivo. Contrary to expectations, Geminin deficiency does not alter development and differentiation of T cells in vivo. Our data suggest that Geminin is required for the proliferation events taking place either in vitro upon TCR receptor activation or during homeostatic expansion, but appears to be redundant for the proliferation and differentiation of the majority of progenitor T cell populations.
Transient Receptor Potential Melastatin 2 Is Required for Lipopolysaccharide-Induced Cytokine Production in Human Monocytes
Authors: Wehrhahn Janine , Kraft Robert , Harteneck Christian , Hauschildt Sunna 
Published: January 2010

Abstract
Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable nonselective cation channel that is stimulated by oxidative stress and specifically activated by intracellular ADP-ribose. Because TRPM2 is highly expressed in immunocytes, a role of this channel in inflammation processes has been proposed. The aim of the current study was to determine the function of TRPM2 in LPS-induced cytokine production of human monocytes. Incubation of human primary monocytes with LPS resulted in an upregulation of TRPM2 mRNA, protein, and of ADP-ribose–induced membrane currents. By using short hairpin RNA to downregulate TRPM2 expression in THP-1 monocytes, we demonstrate that TRPM2 is required for the LPS-induced production of IL-6, IL-8, IL-10, and TNF-α. Application of LPS led to a time-dependent increase in intracellular Ca2+ concentrations in THP-1 cells that was clearly reduced by downregulation of TRPM2. Omission of extracellular Ca2+ strongly decreased TNF-α production in TRPM2-expressing cells. Thus, TRPM2-mediated Ca2+ entry is a central mechanism for LPS-induced cytokine production in monocytic cells. The identification of TRPM2 as a major player in this LPS-dependent process makes it a promising tool in modulating monocyte functions.
Behavioral Interventions to Improve Breast Cancer Screening Outreach
Authors: Mehta Shivan J. , Rhodes Corinne , Linn Kristin A. , Reitz Catherine , McDonald Caitlin , Okorie Evelyn , Williams Keyirah , Resnick David , Arostegui Annamaria , McAuliffe Timothy , Wollack Colin , Snider Christopher K. , Peifer MaryAnne K. , Weinstein Susan P. 
Published: May 2024

ImportanceDespite public health efforts, breast cancer screening rates remain below national goals.ObjectiveTo evaluate whether bulk ordering, text messaging, and clinician endorsement increase breast cancer screening rates.Design, Setting, and ParticipantsTwo concurrent, pragmatic, randomized clinical trials, each with a 2-by-2 factorial design, were conducted between October 25, 2021, and April 25, 2022, in 2 primary care regions of an academic health system. The trials included women aged 40 to 74 years with at least 1 primary care visit in the past 2 years who were eligible for breast cancer screening.InterventionsPatients in trial A were randomized in a 1:1 ratio to receive a signed bulk order for mammogram or no order; in a factorial design, patients were concurrently randomized in a 1:1 ratio to receive or not receive text message reminders. Patients in trial B were randomized in a 1:1 ratio to receive a message signed by their primary care clinician (clinician endorsement) or from the organization (standard messaging); in a factorial design, patients were concurrently randomized in a 1:1 ratio to receive or not receive text message reminders.Main Outcomes and MeasuresThe primary outcome was the proportion of patients who completed a screening mammogram within 3 months.ResultsAmong 24 632 patients included, the mean (SD) age was 60.4 (7.5) years. In trial A, at 3 months, 15.4% (95% CI, 14.6%-16.1%) of patients in the bulk order arm and 12.7% (95% CI, 12.1%-13.4%) in the no order arm completed a mammogram, showing a significant increase (absolute difference, 2.7%; 95% CI, 1.6%-3.6%; P &amp;lt; .001). In the text messaging comparison arms, 15.1% (95% CI, 14.3%-15.8%) of patients receiving a text message completed a mammogram compared with 13.0% (95% CI, 12.4%-13.7%) of those in the no text messaging arm, a significant increase (absolute difference of 2.1%; 95% CI, 1.0%-3.0%; P &amp;lt; .001). In trial B, at 3 months, 12.5% (95% CI, 11.3%-13.7%) of patients in the clinician endorsement arm completed a mammogram compared with 11.4% (95% CI, 10.3%-12.5%) of those in the standard messaging arm, which was not significant (absolute difference, 1.1%; 95% CI, −0.5% to 2.7%; P = .18). In the text messaging comparison arms, 13.2% (95% CI, 12.0%-14.4%) of patients receiving a text message completed a mammogram compared with 10.7% (95% CI, 9.7%-11.8%) of those in the no text messaging arm, a significant increase (absolute difference, 2.5%; 95% CI, 0.8%-4.0%; P = .003).Conclusions and RelevanceThese findings show that text messaging women after initial breast cancer screening outreach via either electronic portal or mailings, as well as bulk ordering with or without text messaging, can increase mammogram completion rates.Trial RegistrationClinicalTrials.gov Identifier: NCT05089903
Relaxation Therapy and Human Milk Feeding Outcomes
Authors: Levene Ilana , Mohd Shukri Nurul Husna , O’Brien Frances , Quigley Maria A. , Fewtrell Mary 
Published: May 2024

ImportanceHuman milk feeding is a key public health goal to optimize infant and maternal/parental health, but global lactation outcomes do not meet recommended duration and exclusivity. There are connections between lactation and mental health.ObjectiveTo appraise all available evidence on whether the provision of relaxation interventions to lactating individuals improves lactation and well-being.Data SourcesEmbase, MEDLINE, CINAHL, Allied and Complementary Medicine Database, Web of Science, and the Cochrane Library were searched on September 30, 2023, and topic experts were consulted.Study SelectionTwo independent reviewers screened for eligibility. Inclusion criteria were full-text, peer-reviewed publications with a randomized clinical trial design. Techniques that were entirely physical (eg, massage) were excluded. A total of 7% of initially identified studies met selection criteria.Data Extraction and SynthesisTwo independent reviewers extracted data and assessed risk of bias with the Cochrane Risk of Bias 2 tool. Fixed-effects meta-analysis and Grading of Recommendations, Assessment, Development, and Evaluations guidelines were used to synthesize and present evidence.Main Outcomes and MeasuresPrespecified primary outcomes were human milk quantity, length and exclusivity of human milk feeding, milk macronutrients/cortisol, and infant growth and behavior.ResultsA total of 16 studies were included with 1871 participants (pooled mean [SD] age for 1656 participants, 29.6 [6.1] years). Interventions were music, guided relaxation, mindfulness, and breathing exercises/muscle relaxation. Provision of relaxation was not associated with a change in human milk protein (mean difference [MD], 0 g/100 mL; 95% CI, 0; 205 participants). Provision of relaxation was associated with an increase in human milk quantity (standardized mean difference [SMD], 0.73; 95% CI, 0.57-0.89; 464 participants), increased infant weight gain in breastfeeding infants (MD, z score change = 0.51; 95% CI, 0.30-0.72; 226 participants), and a slight reduction in stress and anxiety (SMD stress score, −0.49; 95% CI, −0.70 to −0.27; 355 participants; SMD anxiety score, −0.45; 95% CI, −0.67 to −0.22; 410 participants).Conclusions and RelevanceResults of this systematic review and meta-analysis suggest that provision of relaxation was associated with an increase in human milk quantity and infant weight gain and a slight reduction in stress and anxiety. Relaxation interventions can be offered to lactating parents who would like to increase well-being and improve milk supply or, where directly breastfeeding, increase infant weight gain.
Use of Implementation Strategies to Promote the Uptake of Knee Osteoarthritis Practice Guidelines and Improve Patient Outcomes: A Systematic Review
Authors: Ramirez Michelle M. , Fillipo Rebecca , Allen Kelli D. , Nelson Amanda E. , Skalla Lesley A. , Drake Connor D. , Horn Maggie E. 
Published: May 2024

ObjectiveTranslation of knee osteoarthritis (KOA) clinical practice guidelines (CPGs) to practice remains suboptimal. The primary purpose of this systematic review was to describe the use of implementation strategies to promote KOA CPG–recommended care.MethodsMedline (via PubMed), Embase, CINAHL, and Web of Science were searched from inception to February 23, 2023, and the search was subsequently updated and expanded on January 16, 2024. Implementation strategies were mapped per the Expert Recommendations for Implementing Change taxonomy. Risk of bias (RoB) was assessed using the Cochrane Effective Practice and Organisation of Care criteria. The review was registered prospectively (PROSPERO identifier: CRD42023402383).ResultsNineteen studies were included in the final review. All (100% [n = 4]) studies that included the domains of “provide interactive assistance,” “train and educate stakeholders” (89% [n = 16]), “engage consumers” (87% [n = 13]), and “support clinicians” (79% [n = 11]) showed a change to provider adherence. Studies that showed a change to disability included the domains of “train and educate stakeholders,” “engage consumers,” and “adapt and tailor to context.” Studies that used the domains “train and educate stakeholders,” “engage consumers,” and “support clinicians” showed a change in pain and quality of life. Most studies had a low to moderate RoB.ConclusionImplementation strategies have the potential to impact clinician uptake of CPGs and patient‐reported outcomes. The implementation context, using an active learning strategy with a patient partner, restructuring funding models, and integrating taxonomies to tailor multifaceted strategies should be prioritized. Further experimental research is recommended to determine which implementation strategies are most effective.image
Ultramicrotomy‐Assisted Fabrication of Nanochannels for Efficient Ion Transport and Energy Generation
Authors: Bhardwaj Ankit , Gogoi Raj Kumar , Howard William Joshua , Tillotson Evan , Goutham Solleti , You Yi , Hashimoto Teruo , Janzen Eli , Edgar James H. , Haigh Sarah J. , Keerthi Ashok , Radha Boya 
Published: May 2024

AbstractNano‐ and angstrom‐scale channels fabricated from 2D‐layered materials provide a unique platform for studying fluidic behavior at atomic‐scale confinement, with applications in desalination, osmotic power generation, and fuel cells. While various fabrication methods exist, achieving precision, scalability, and minimal fabrication time is challenging. Ultramicrotomy‐based nanofabrication is shown here as an efficient approach to create nanofluidic membranes containing nanochannels with atomically flat walls. This approach is compatible with both bottom–up nanolaminates and top–down nanochannels, produces multiple devices from the same 2D assembly and allows swift variation of channel length. Integration of these membranes into macroscopic silicon fluidic‐chips is achieved maintaining the structural and functional properties. The robustness of the sliced membranes is demonstrated through restacked vermiculate laminates that sustain applied pressures and generate ionic streaming currents. Sliced pristine vermiculite channels exhibit charge‐selective ion transport, leading to osmotic power density (Posm/A) ranging from 9.2 to 300.4 Wm−2 under various KCl concentration gradients. Maximum conversion efficiency of 23.3% is obtained at a 100‐fold gradient, yielding Posm/A of 234.6 Wm−2. Short channel lengths sliced by ultramicrotomy contribute to high Posm/A, promising applications of miniature energy devices for pressure‐driven electricity generation and osmotic power generation.
Artificial Compound Eye with Tunable Properties for Enhancement in Fluorescence Imaging and Raman Detection
Authors: Kassim Kehinde , Lu Qiuyun , Maeda Nobuo , Wang Xihua , Xu Ben Bin , Zhang Xuehua 
Published: May 2024

AbstractArtificial compound eye (CE) draws inspiration from nature, offering advanced imaging capabilities and an expansive field of view. In this work, an innovative technique is developed for the creation of CE with tunable dimensions. A solution‐based process is employed that involves in situ polymerization of surface nanodroplets prior to soft lithography to produce CE consisting of millions of ommatidia. The fabricated CE comprised of a densely arranged array of microwells, each with a base radius of 5 µm. Situated on a millimeter‐sized spherical dome, the CE can be tailored to arbitrary dimensions, enhancing its adaptability with a wide angular field of view up to 118°. The CE is used to enhance signal detection in fluorescent compounds, reaching a detection limit of 107 times lower concentration than that without using CEs in bulk solution. The signal enhancement capabilities are further utilized for surface‐enhanced Raman spectroscopy by using a portable handheld device, with an enhancement factor of 2. The fabrication technique underscores the advantages of the approach in simplicity, reproducibility, and efficiency in creating CE. The potential applications of CE may be extended to various domains, such as optical sensing, light‐dependent signal enhancement, motion perception, and medical endoscopy.
Hybrid Cell Membrane‐Based Nanoplatforms for Enhanced Immunotherapy against Cancer and Infectious Diseases
Authors: Peng Xinran , Yang Li , Yuan Peiyan , Ding Xin 
Published: May 2024

AbstractImmunotherapy based on nanoplatforms is a promising approach to treat cancer and infectious diseases, and it has achieved considerable progress in clinical practices. Cell membrane‐based nanoplatforms endow nanoparticles with versatile characteristics, such as half‐life extension, targeting ability, and immune‐system regulation. However, monotypic cell membrane usually fails to provoke strong immune response for immunotherapy while maintaining good biosafety. The integration of different cell‐membrane types provides a promising approach to construct multifunctional nanoplatforms for improved immunotherapeutic efficacy by enhancing immunogenicity or targeting function, evading immune clearance, or combining with other therapeutic modalities. In this review, the design principles, preparation strategies, and applications of hybrid cell membrane‐based nanoplatforms for cancer and infection immunotherapy are first discussed. Furthermore, the challenges and prospects for the potential clinical translation of hybrid cell membrane‐based nanoplatforms are discussed.
Tandem Electric‐Fields Prolong Energetic Hot Electrons Lifetime for Ultra‐Fast and Stable NO2 Detection
Authors: Ou Yucheng , Wang Bing , Xu Nana , Song Quzhi , Liu Tao , Xu Hui , Wang Fuwen , Li Siwei , Wang Yingde 
Published: May 2024

AbstractProlonging energetic hot electrons lifetimes and surface activity in the reactive site can overcome the slow kinetics and unfavorable thermodynamics of photo‐activated gas sensors. However, bulk and surface recombination limit the simultaneous optimization of both kinetics and thermodynamics. Here tandem electric fields are deployed at (111)/(100)Au‐CeO2 to ensure a sufficient driving force for carrier transfer and elucidate the mechanism of the relationship between charge transport and gas‐sensing performance. The asymmetric structure of the (111)/(100)CeO2 facet junction provides interior electric fields, which facilitates electron transfer from the (100)face to the (111)face. This separation of reduction and oxidation reaction sites across different crystal faces helps inhibit surface recombination. The increased electron concentration at the (111)face intensifies the interface electric field, which promotes electron transfer to the Au site. The local electric field generated by the surface plasmon resonance effect promotes the generation of high‐energy energy hot‐electrons, which maintains charge concentration in the interface field by injecting into (111)/(100)CeO2, thereby provide thermodynamic contributions and inhibit bulk recombination. The tandem electric fields enable the (111)/(100)Au‐CeO2 to rapidly detect 5 ppm of NO2 at room temperature with stability maintained within 20 s.
Carbon Dioxide Capture by Emerging Innovative Polymers: Status and Perspectives
Authors: Darmayanti Made Ganesh , Tuck Kellie L. , Thang San H. 
Published: May 2024

AbstractA significant amount of research has been conducted in carbon dioxide (CO2) capture, particularly over the past decade, and continues to evolve. This review presents the most recent advancements in synthetic methodologies and CO2 capture capabilities of diverse polymer‐based substances, which includes the amine‐based polymers, porous organic polymers, and polymeric membranes, covering publications in the last 5 years (2019–2024). It aims to assist researchers with new insights and approaches to develop innovative polymer‐based materials with improved capturing CO2 capacity, efficiency, sustainability, and cost‐effective, thereby addressing the current obstacles in carbon capture and storage to sooner meeting the net‐zero CO2 emission target.
Scalable Customization of Crystallographic Plane Controllable Lithium Metal Anodes for Ultralong‐Lasting Lithium Metal Batteries
Authors: Tan Jian , Ma Longli , Yi Pengshu , Wang Yuan , Li Zhiheng , Fang Zhan , Li Xuanyang , He Shan , Wang Xuefeng , Ye Mingxin , Shen Jianfeng 
Published: May 2024

AbstractA formidable challenge to achieve the practical applications of rechargeable lithium (Li) metal batteries (RLMBs) is to suppress the uncontrollable growth of Li dendrites. One of the most effective solutions is to fabricate Li metal anodes with specific crystal plane, but still lack of a simple and high‐efficient approach. Herein, a facile and controllable way for the scalable customization of polished Li metal anodes with highly preferred (110) and (200) crystallographic orientation (donating as polished Li(110) and polished Li(200), respectively) by regulating the times of accumulative roll bonding, is reported. According to the inherent characteristics of polished Li(110)/Li(200), the influence of Li atomic structure on the electrochemical performance of RLMBs is deeply elucidated by combining theoretical calculations with relative experimental proofs. In particular, a polished Li(110) crystal plane is demonstrated to induce Li+ uniform deposition, promoting the formation of flat and dense Li deposits. Impressively, the polished Li(110)||LiFePO4 full cells exhibit unprecedented cycling stability with 10 000 cycles at 10 C almost without capacity degradation, indicating the great potential application prospect of such textured Li metal. More valuably, this work provides an important reference for low‐cost, continued, and large‐scale production of Li metal anodes with highly preferred crystal orientation through roll‐to‐roll manufacturability.
Coupling‐Grafting‐Ultrasonication Modification of Electrophoretic Particles for Fast Response and High Contrast Ratio Electrophoretic Display
Authors: Zhang Yue , Yang Jinglan , Xiong Feng , Wu Xinzao , Zeng Debo , Zhou Tao , Yang Bo‐Ru 
Published: May 2024

AbstractElectrophoretic displays (EPDs) show great promise in the field of information display because of their eye‐friendly feature and high ambient visibility. Enhancing electrophoretic particle preparation and optimizing charge properties are crucial for display quality, response speed, and the capability to show full color. Despite the various methods explored, achieving a balance among simplicity, cost‐effectiveness, high surface charge, rapid response, and contrast improvement remains challenging. This study introduces a coupling‐grafting‐ultrasonication (CGU) approach. The surface charge and stability of the particles are turned by precisely adjusting the thickness of the poly (lauryl methacrylate) (PLMA) layer. Through optimization, TiO2‐PLMA electrophoretic particles with a grafting mass of 10 exhibit a fast response (170 ms for white, 120 ms for black), high contrast (30), and demonstrated long‐term stability in EPD devices. Furthermore, the CGU method proves to be versatile for colored EPD particle preparation, providing a new direction for the future development of EPD.
Demonstration of In‐Memory Biosignal Analysis: Novel High‐Density and Low‐Power 3D Flash Memory Array for Arrhythmia Detection
Authors: Kim Jangsaeng , Im Jiseong , Shin Wonjun , Lee Soochang , Oh Seongbin , Kwon Dongseok , Jung Gyuweon , Choi Woo Young , Lee Jong‐Ho 
Published: May 2024

AbstractSmart healthcare systems integrated with advanced deep neural networks enable real‐time health monitoring, early disease detection, and personalized treatment. In this work, a novel 3D AND‐type flash memory array with a rounded double channel for computing‐in‐memory (CIM) architecture to overcome the limitations of conventional smart healthcare systems: the necessity of high area and energy efficiency while maintaining high classification accuracy is proposed. The fabricated array, characterized by low‐power operations and high scalability with double independent channels per floor, exhibits enhanced cell density and energy efficiency while effectively emulating the features of biological synapses. The CIM architecture leveraging the fabricated array achieves high classification accuracy (93.5%) for electrocardiogram signals, ensuring timely detection of potentially life‐threatening arrhythmias. Incorporated with a simplified spike‐timing‐dependent plasticity learning rule, the CIM architecture is suitable for robust, area‐ and energy‐efficient in‐memory arrhythmia detection systems. This work effectively addresses the challenges of conventional smart healthcare systems, paving the way for a more refined healthcare paradigm.