bluuebunny/crossref_metadata_2025_split huggingface dataset:
PW01-38 - Maintenance Treatment With Quetiapine Added To Either Lithium or Divalproex In Bipolar I Disorder
Authors: Suppes T. , Vieta E. , Gustafsson U. , Paulsson B. 
Published: June 2010

ObjectiveCombined data are presented from 2 long-term studies (D1447C00126; D1447C00127) of QTP in combination with Li or DVP in the prevention of mood events in bipolar I disorder. Data from Li and DVP treatment groups are analyzed separately to determine the added benefit of QTP.MethodsPatients received QTP (400-800 mg/d)+Li/DVP to achieve ≥12 weeks of clinical stability followed by double-blind treatment with QTP (400-800 mg/d)+Li/DVP or PBO+Li/DVP for up to 104 weeks. Li or DVP treatment was openly assigned at the discretion of the investigator. Primary endpoint was time to first mood event post-randomization.Results1326 patients were included in the ITT population. In both Li and DVP groups, the risk of recurrence of any mood event was significantly reduced following treatment with QTP relative to placebo (HR, 0.32, 95% CI, 0.24-0.44 and HR, 0.28, 95% CI, 0.21-0.37; for Li and DVP, respectively; P< 0.0001 for both). This trend was repeated for risk of recurrence of mania and depression events (P< 0.0001 vs placebo). Comparison of QTP+Li versus QTP+DVP groups revealed no differences in the risk of recurrence of mood, mania, or depression events. Safety data were generally consistent with the recognized safety profiles of QTP, Li, and DVP.ConclusionsIn stable patients with bipolar I disorder, treatment with QTP, in combination with either Li or DVP, resulted in similar significant increases in the time to recurrence of a mood event (mania or depression) compared with placebo, regardless of Li or DVP co-treatment.Supported funding from AstraZeneca Pharmaceuticals.
PW01-49 - Depersonalization In Patients With Panic Disorder: Role Of Personality
Authors: Mendoza L. , López H. , Rodriguez A. , Navinés R. , Imaz M.L. , Gutierrez F. , Crippa J.A. , Martín-Santos R. 
Published: June 2010

IntroductionDepersonalization (DP) is a common and complex clinical phenomenon in neurology and psychiatry. It is defined as an experience in which the individual feels a sense of unreality and detachment from him/herself. Prevalence and clinical correlates of dissociative symptoms in general, and DP in particular have been associated to panic disorder (Hunter et al., 2004). Moreover, DP has been associated with certain personality traits, specifically “harm-avoidant” temperament dimension, immature defenses, and overconnection and disconnection cognitive schemata (Simeon et al., 2002).ObjectivesTo investigate the prevalence of DP syndrome in panic disorder and its relationship with personality.MethodsOne-hundred-four consecutive adult patients with panic disorder were assessed with the Semi- Structured Clinical Interview for DSM-IV-Axis I and II. All participants were evaluated with the Cambridge Depersonalization Scale (Sierra and Berrios, 2000) and the Cloninger Temperament and Character Inventory. The severity of panic disorder was measured with the Panic and Agoraphobia Scale.ResultsSeventeen patients (16.3%) had a DP syndrome. There were not socio-demographic differences between both groups with and without DP syndrome. Patients with DP syndrome showed a higher score in “self-transcendence” character dimension (p< .001), higher prevalence of personality disorders (p=.007) and greater severity of panic disorder (p=.007). A logistic regression analysis showed that severity of panic disorder (p=.031) and higher “self-transcendence” personality dimension (p=.019) predicts DP syndrome in panic disorder patients. The Hosmer-Lemeshow test showed the goodness-of-fit of the model.ConclusionsThe study confirms the association of DP syndrome with panic disorder and their relationship with “self-transcendence” personality dimension.
PW01-52 - Post-Traumatic Stress Disorder (Ptsd) Among Emergency Medicine Staff
Authors: Saberi H. 
Published: June 2010

ObjectivesEmergency department staff and emergency medicine personnel in particular are at risk of various types of occupational stresses such as mental traumas. Little information is available about possibility and rate of PTSD among emergency medicine staff in Iran and the world as well. This study is to cover the prevalence of and affecting factors on the PTSD among the EM personnel in Iran.MethodsIn an analytic-descriptive study in 2009, 150 emergency medicine personnel of Kashan and Arak city were investigated to estimate both the PTSD rate and severity of mental traumas. Standard questionnaires of IES 15 and PTSS 10 along with DSM- IV criteria were utilized in this regard.Results121 out of 150 subjects answered the questionnaires. All the clients were examined in terms of DSM- IV criteria in which 44 (36.4%) ones met the PTSD diagnostic criteria. In the IES scale, one third of the EM staff belonged to the event severely affected group. 11 (9%) subjects received a 5 or more PTSD score demonstrating a relatively severe reaction in them. Marital status had a meaningful correlation with PTSD condition, so that the single were more likely to meet the PTSD criteria.ConclusionsAccording to the study, rate of PTSD and severity of the traumas resulted among the emergency medicine personnel were both high to a great extent. It seems that these individuals are severely exposed to occupational stress and the pertinent complications, and further attention should be given to their psychological condition then.
PW01-56 - Peculiarities Of Teenagers’ Suicidal Behavior
Authors: Adomaitienė V. , Jaras A. , Lauciūtė E. , Dambrauskienė K. , Taranda V. , Vilkas V. 
Published: June 2010

ObjectiveSuicide is one of predominant causes of death among young Europeans. Recent statistical data on suicide proves that Lithuania is one of the leading countries in this domain. The goal of this study is to define and compare the peculiarities of suicidal behavior among teenage boys and girls.Methods109 teenagers of the age 14 to 17 years old (52 boys and 57 girls), who were treated in Kaunas University of Medicine Psychiatry Clinic Children - Teenagers’ Department after suicide attempts, took part in the study. Medical documentation and structured questionnaire designed by the authors were used.ResultsThe incidence of suicidal thoughts among teenagers who attempted suicide was compared according to gender. It was determined that almost one fourth of the boys (23,1%) and one sixth of the girls (17,5%) have never thought about committing suicide before they attempted to do that. Almost every other boy (48,1%) and 40,4% of the girls have had suicidal thoughts a few times a year. One fourth of the boys (28,8%) and one third of the girls (36,8%) have had suicidal thoughts a few times per month or per week. And only a few girls (5,3%) still had suicidal thoughts after a suicidal attempt (X2=4,04, df=3, p=0,3).ConclusionsNo statistical gender differences were found in estimating the incidence of suicidal thoughts among teenagers who attempted suicide.
PW01-58 - Association Between Depressive Symptoms And Pubertal Status In Boys And Girls From A Uk Cohort
Authors: Joinson C. , Heron J. , Araya R. , Lewis G. 
Published: June 2010

ObjectivesTo examine the association between advancing pubertal status and the emergence of depressive symptoms in boys and girls from a UK cohort.MethodsSelf-reported depressive symptoms were assessed using the Short Mood and Feelings Questionnaire at three time-points (10.5, 13 and 14 years). We derived trait measures of depressive symptom level at each time-point using confirmatory factor analysis and compared the 3 depressive symptom factors with pubertal status (using regular self-reported Tanner assessments from 8-14 years) separately in boys (n=2902) and girls (n=2886). Main effects were estimated, adjusted for time lag between assessment of pubertal status and depressive symptoms, and then further adjusted for confounders (social class, maternal education, parental separation, financial problems, housing tenure).ResultsFor girls at age 10.5 years, there was little evidence of a relationship between pubertal status and depressive symptoms, with an increase in symptoms of 0.025 SD's for each additional pubertal stage (indicated by Tanner stages 1 through 5) for breast development and 0.023 SD's for each additional stage for pubic-hair development. With increasing age, the association between pubertal stage and depressive symptoms in girls strengthened. At age 14 years, advancement of each pubertal stage represented an increase in 0.13 SD's of depressive symptoms for breast development and 0.10 SD's for pubic hair development. For boys, there was no clear relationship between pubertal development and depressive symptoms at any time-point.ConclusionsMore advanced pubertal status was associated with an increased level of depressive symptoms in girls in early/mid adolescence but not boys.
PW01-63 - Functionality And Quality Of Life In Children And Adolescents With Adhd Transitioning To Oros Mph - Correlations Of Outcomes
Authors: Niederkirchner K. , Mattejat F. , Dichter S. , Schaeuble B. 
Published: June 2010

ObjectiveTo explore correlations of outcomes in children and adolescents with ADHD transitioning from IR MPH onto OROS MPH.MethodsPost hoc analyses of a 12 week open label trial in patients (6-18 yrs) with a diagnosis of ADHD (ICD-10) transitioning from IR MPH onto OROS MPH. Assessments included Conners parents rating scale, children's global assessment scale and quality of life (ILC; LK0-28) of patients, including self rating and parent's rating. A regression model on difference in CPRS at endpoint from baseline as dependent variable and sex, age, baseline CPRS and diagnosis as explanatory variables was performed. Relationships between ILC, CPRS and C-GAS scores were assessed by Spearman's rank correlation coefficients.Results598 patients (ITT population; 84.8% boys; median 10 yrs) received a median starting and final dose of PR OROS MPH of 36 mg/day. Scores on C-GAS, CPRS, ILC (parents and patients) improved (p< 0.001). Burden of disease in care givers and children decreased (p< 0.001). Older age, poor baseline score, diagnosis of F.90.0 (hyperkinetic disorder) were associated with greater improvements on CPRS. The difference between endpoint versus baseline scores of patient's and parent's rating of patient's ILC, C-GAS and ILC (patients'rating) correlated. ILC (parents'rating) and CPRS correlated inversely (a decrease in CAARS was associated with higher scores on ILC).ConclusionTransitioning to OROS MPH was associated with improvement in daily functioning, quality of life and decreased burden of disease. Improvement in symptoms was associated with improved quality of life aspects and better social functioning.
PW01-81 - Deficits of Spatial Memory and Oxidative Stress Damage Following Exposure to Lipopolysaccharide in a Rat Model of Parkinson's Disease
Authors: Hritcu L. , Ciobica A. , Stefan M. , Nabeshima T. 
Published: June 2010

ObjectivesThe present work was undertaken in order to investigate the effects of systemic lipopolysaccharide endotoxin administration (250 μg/kg) on spatial memory formation and oxidative stress in rats subjected to right-unilateral lesion of the dopaminergic neurons of the substantia nigra by means of 6- hydroxydopamine (6-OHDA) compared to normal and lipopolysaccharide alone treated rats.MethodsThirty male Wistar rats weighing 200 ± 50 at the start of the experiment were used. The substantia nigra was right-unilateral lesioned by stereotaxic microinjections of 8 micrograms (free base) 6-OHDA. The rats were pretreated 30 min before the 6-OHDA infusion with 25 mg/kg desipramine to protect noradrenergic projections. Sham-operated rats received only an injection of desipramine, followed by vehicle in the substantia nigra. Lipopolysaccharide (LPS from Escherichia coli serotype 0111:B4, Sigma) was dissolved in pyrogen-free 0.9% NaCl at the concentration of 250 μg/kg and intraperitonealy injected in normal and 6-OHDA-lesioned rats for a period of 7 continuous days. 7 days after continuous LPS administration we assessed memory formation by means of Y-maze and radial arm-maze task, and the endogenous antioxidants activity in rat temporal cortical area.ResultsSystemic lipopolysaccharide administration significantly decreased spontaneous alternation in Y-maze task, working memory and reference memory in radial arm-maze task, suggesting impairment of both short-term memory and long term-memory, respectively. Furthermore, lipopolysaccharide administration significantly decreased activity of the biochemical markers of endogenous antioxidants in rat temporal cortical area.ConclusionsOur results further validate that lipopolysaccharide may exacerbate the development of neurological dysfunctions associated with Parkinson's disease.
PW01-83 - Co-Morbidity And Mortality In Vascular Dementia: A Naturalistic Follow-Up 2000 To 2007
Authors: Malik A. , Potlori R. , Natalwala A. , Heun R. 
Published: June 2010

IntroductionVascular Dementia (VD) patients have increased co-morbidity and higher mortality in comparison to other patients. Neuro-degeneration, cognitive deficits and underlying medical conditions may influence the pattern of co-morbid disorders and their possible effects on mortality in VD.AimTo investigate whether the pattern of co-morbidity and its relevance for later death differed between hospitalised VD and elderly controls.MethodDiseases with a prevalence of more than 1% at hospital admission were compared between 341 hospitalised VD and 72244 control subjects aged above 70 years referred to the University of Birmingham Hospital, UK. Risk factors i.e. co-morbidities that were predictors of mortality within the seven year follow-up were identified using logistic regression and cox regression analyses. Confidence intervals of relative risks were used to compare the relevance of risk factors for later mortality between groups.ResultsSubjects with VD suffer more with peripheral vascular disease, atrial fibrillation, type 2 diabetes mellitus, pneumonia, ischemic stroke and urinary tract infections than other hospitalised elderly patients. In contrast, myocardial infarction was less prevalent in VD subjects in comparison with hospitalised controls. The prevalence of hypertension, ischemic heart disease, angina and heart failure was not statistically different in the two groups.ConclusionPatients with Vascular Dementia have a different pattern of co-morbidity, but die from the same diseases as other hospitalised patients. Infections including pneumonia may need special attention in patients with vascular dementia who might not be able to identify or report the early symptoms.
PW01-84 - Mild Cognitive Impairment - Clinical And Imaging Features In Arad County
Authors: Mila C. , Podea D.M. , Chenderes R.M. 
Published: June 2010

Mild Cognitive Impairment (MCI)is the most obvious decrease mental function, considered to be a potential transitional stage between normal cognitive function and dementia. The number of older people is growing rapidly worldwide and the fact that elderly people are also apparently living longer, dementia, the most common cause of cognitive impairment is getting to be a greater public health problem.ObjectiveThe aim of this study is to evaluate the correlation between clinical features and imaging aspects at patient diagnosed with MCI.Material and methodsThe study comprises a number of 45 elderly patients diagnosed with MCI. MMSE score between 28-21 points is considered mild cognitive impairment. The patients were evaluated with MMSE (Mini Mental State Evaluation), clock drawing test (CDT), Raven QI test and computer tomography.ResultsThe average of MMSE was 23.88. The most affected items of MMSE were attention, concentration and recall. The results CDT was reduced on average by 2.57 points from the maximum of 4 points. Raven test showed that almost all the patient included presented QI under 90 points, an intelligence level under limits. The patients with lower MMSE score have more than one imaging change. All the patients with low CDT score have cortical atrophy.ConclusionsIn general imaging changes are correlated with MMSE and CDT scores: as the scores are lower the tomography changes are more severe.AcknowledgmentThe work reported in this paper was supported by grant PNCDI2-41-057/2007 from the Romanian Ministry of Education and Research.
PW01-90 - Influence Of Apolipoprotein E Genotype On Cognitive Function In Patients With Mild Alzheimer Dementia
Authors: Stoppe G. , Saake A. , Wolf S. 
Published: June 2010

BackgroundApolipoprotein E allele ɛ4 is a well established risk factor for Alzheimer dementia (AD). Its presence modifies also the influence of other risk factors as well as the conversion rate of mild cognitive impairment (MCI) to overt dementia. In how far it also influences the clinical presentation of AD, is not known yet.MethodPatients of the memory clinic Göttingen were approached if they fulfilled the inclusion criteria: very mild or mild AD according to NINCDS-ADRDA criteria, MMSE 20-30, and at least two of three typical instrumental findings (hippocampal atrophy in MRI, bilateral temporo-parietal hypoperfusion in Neurolite-SPET, low Aβ1-42and increased tau in CSF). They underwent an extensive neuropsychological investigation. A follow-up took place within one year.ResultsN=74 patients (38M, 36F; mean age 68.1y; MMSE 25.9 ± 2.8) and N=28 age- and sex- and education-matched controls could be recruited. N=36 patients had one (N=20) or two (N=16) APOE -ɛ4-alleles. 53 of 57 CSF analyses revealed AD-typical findings, 64 of 74 cranial MRT revealed bilateral hippocampal or global atrophy and 42 of 64 Neurolite-SPETs showed typical findings. Results of non-memory tests - language, visuospatial ability, attention - did not reveal any difference with regard to APOE genotype. Two memory tests and a memory composite score were significantly worse in the APOE -ɛ4-positive group and even worse in the homozygote group.ConclusionAPOE -ɛ4 influences in a dose dependent manner the neuropsychological functioning in mild AD.
PW01-106 - Evaluation Of The Effect Of Religiosity On Mental Health Of Nursing Students In Northern Greece
Authors: Papazisis G. , Tsiga E. , Katsigiannopoulos K. , Lagos I.-C. , Koutsoumpelis P. , Katis V. , Sapountzi-Krepia D. 
Published: June 2010

IntroductionReligious and spiritual beliefs are widely recognized as important components of human wellness, of health care outcomes and of holistic medical and nursing care. There are controversial data suggesting a correlation between religiosity and mental health disorders among young adults and students. Aim of the study was to determine the association between self-esteem, depression and religious and spiritual beliefs among nursing students in Thessaloniki, Greece.MethodsA total of 122 students agreed to participate in the study. Data was collected using the Greek versions of three self-administered, structured, pre-tested questionnaires: I) The Royal Free Interview for Religious and Spiritual Beliefs II) Beck Depression Inventory (BDI-II) and III) Rosenberg self-esteem scale.ResultsSelf-esteem was found normal in 89,3% of the students, low in 10,7%, but it is important to notice that nobody reported high self-esteem levels. The vast majority of the students (61,5%) reported both religious and spiritual beliefs. 27% reported only religious beliefs and 9% only spiritual beliefs. 31,9% of the students perceived depressive symptoms, most of them in mild levels (19,5%). Praying, religious reading and religious attendance were associated with normal self-esteem and low depressive symptoms. However, a consistent negative correlation was found between intrinsic religiosity and depression.DiscussionThese findings indicate that religious and spiritual variables influence the psychological well-being of students. Religiosity may have a protective role against depression; however, our study sample is relative small and further studies are required in order to evaluate the effect of religious beliefs on the mental health of students.
PW01-111 - Prevalence Of Insomnia In General Population
Authors: Sepehrmanesh Z. , Ahmadvand A. , Ghoreishi F. 
Published: June 2010

ObjectivesSleep is the most important biological circadian rythm. Researches have shown that sleep deprivation causes reduction of hypothalamus function, decrease glucose tolerance and increase cardio-vascular diseases, hypertension and also decrease their mental and intellectual activity of human. This research investigate insomnia in adult people (Kashan city,Iran.)MethodsThis cross-sectional research has been done in Kashan,2008 by using classified randomized sampling in 39 health centers among persons with 18 years old and over (N= 1155). Written consent was taken from subjects, and all of them answered to demographic questionnaire,and researcher-made insomnia questionnaire. Test-retest Reliability of this test was 99% and its internal consistency was 82% by using α kronbach. Data was analyzed by using Fisher exact test.ResultsPrevalence of insomnia was (n=684, 59.2%). The highest rate of insomnia were found among adult with age of 42 to 65 years old (n=266, 67.9%) and then in sex of feminity (n=387, 56.5%). There was significant relationship between insomnia and psychiatric history [PV< 0/0001, OR=2.24], sleep disorder in family [PV< 0/0001, OR=4.67] and drinking caffeine before sleep [PV< 0/001, OR=1.64].ConclusionsThe majority of adult person suffer from insomnia and most sleep problems are observed among middle age group. Since sleep disorders can be related to social, psychological and physical problems, paying attention to quality and hygiene sleep in general population is essential.
PW01-114 - Neurosyphilis With Psychiatric Co-Morbidity In General Hospitals In The Netherlands, 1999-2007
Authors: Lens - Daey Ouwens I.M. , van Veen M.G. , van den Wijngaard C.C. , Notermans D.W. , de Vries H.J.C. , van der Sande M. 
Published: June 2010

IntroductionRecent surveys show a steady increase in infectious syphilis incidence among sexual transmitted infection clinic visitors in many industrialized countries. Untreated, 30% of patients develop symptomatic neurosyphilis, possibly presenting with a variety of behavioral en neurological symptoms. Neurosyphilis is diagnosed on specific abnormalities in cerebrospinal fluid (CSF).ObjectivesCase reports on neurosyphilis in Dutch patients prompted us to explore the epidemiology of neurosyphilis with psychiatric co morbidity.AimTo estimate the incidence of neurosyphilis and psychiatric co morbidity in the Netherlands based on data of hospitalizations in general hospitals from 1999-2007.MethodsHospitalization data were collected from the Dutch National Medical Register. We included all records on hospitalizations with any kind of neurosyphilis, except congenital neurosyphilis, as discharge- or secondary diagnosis (ICD9-code 094 and subcategory codes).ResultsBetween 1999 and 2007, 542 cases of neurosyphilis were registered, approximately 60 cases per year. Of all cases, 76% were male. Co-infection with HIV was seen in 74 (14%) of hospitalized cases of whom 91% were male. In 35 (6%) cases one or more concurrent psychiatric disorders were diagnosed, including 10 organic psychiatric disorders, 8 dementia cases, 6 substance abuses, 4 affective disorders, 7 psychotic disorders, 2 personality disorders and 8 miscellaneous diagnoses.ConclusionsNeurosyphilis is still diagnosed in patients admitted to Dutch general hospitals. Under diagnosis due to unfamiliarity with the recent syphilis surge is possible. Over reporting is also possible due to incorrect diagnosis not based on CSF results. The reemerging syphilis epidemic may result in an increasing neurosyphilis incidence.