bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Chlorinated Briarane Diterpenoids from the Sea Whip Gorgonian Corals Junceella fragilis and Ellisella robusta (Ellisellidae)
Authors: Wang Su‐Hui , Chang Yu‐Chia , Chiang Michael Y. , Chen Yung‐Husan , Hwang Tsong‐Long , Weng Ching‐Feng , Sung Ping‐Jyun 
Published: December 2010

Abstractisolation, structure determination and bioactivity of the two new chlorinated briaranes, fragilide J (I) and robustolide L (II) along with the known metabolite robustolide H
ChemInform Abstract: Castanolide and epi‐Castanolide, Two Novel Diterpenoids with a Unique seco‐Norabietane Skeleton from Salvia castanea Diels f. pubescens Stib.
Authors: Pan Zheng‐Hong , He Juan , Li Yan , Zhao Yu , Wu Xing‐De , Wang Kou , Peng Li‐Yan , Xu Gang , Zhao Qin‐Shi 
Published: December 2010

AbstractPreliminary tests of castanolide (I)(space group P212121 with Z=4) and epi‐castanolide (II)(space group P21 with Z=2) concerning cytotoxicity and PAF antagonistic activity do not reveal any positive results.
ChemInform Abstract: Structure—Activity Relationship of Lupane‐Triterpene Glycosides from Acanthopanax koreanum on Spleen Lymphocyte IL‐2 and IFN‐γ.
Authors: Kim Young Ho , et al. et al. 
Published: December 2010

AbstractThree new lupane‐triterpene glycosides acankoreosides M—O ,(I)—(III), resp.,are isolated along with several known related glycosides from title plant leaves.
ChemInform Abstract: Antimicrobial Phenolic Abietane Diterpene from Lycopus europaeus L. (Lamiaceae).
Authors: Radulovic Niko , Denic Marija , Stojanovic‐Radic Zorica 
Published: December 2010

AbstractA new acetylated highly oxygenated abietane‐type diterpenoid named euroabienol (I) is isolated from Lycopus europaeus L.
ChemInform Abstract: Application of an Enyne Metathesis/Diels—Alder Cycloaddition Sequence: A New Versatile Approach to the Syntheses of C‐Aryl Glycosides and Spiro‐C‐Aryl Glycosides.
Authors: Subrahmanyam Ayyagari V. , Palanichamy Kalanidhi , Kaliappan Krishna P. 
Published: December 2010

AbstractA wide range of C‐aryl [cf.(V)] and spiro‐C‐aryl glycosides [cf.(IX)] is smoothly obtained using the title metathesis—cycloaddition sequence.
ChemInform Abstract: Pollenopyrroside A (I) and B (II), Novel Pyrrole Ketohexoside Derivatives from Bee‐Collected Brassica campestris Pollen
Authors: Guo Juan‐Li , Feng Zi‐Ming , Yang Ya‐Jun , Zhang Zhi‐Wu , Zhang Pei‐Cheng 
Published: December 2010

Abstractisolation, structure and cytotoxicity
ChemInform Abstract: Design, Synthesis and Evaluation of a Novel Double Pro‐Drug: INX‐08189. A New Clinical Candidate for Hepatitis C Virus.
Authors: McGuigan Christopher , et al. et al. 
Published: December 2010

AbstractA phosphoramidate ProTide motif and a 6‐O‐methoxy base pro‐drug moiety are combined to generate lipophilic prodrugs.
ChemInform Abstract: Chlorosulfolipids and the Corresponding Alcohols from the Octocoral Dendronephthya griffini
Authors: Chao Chih‐Hua , Huang Ho‐Cheng , Wang Guey‐Horng , Wen Zhi‐Hong , Wang Wei‐Hsien , Chen I‐Ming , Sheu Jyh‐Horng 
Published: December 2010

Abstractpurification and structure elucidation of the new polychlorolipids (I)
ChemInform Abstract: anti‐Human Immunodeficiency Virus‐1 Constituents of the Bark of Poncirus trifoliata.
Authors: Feng Tao , Wang Rui‐Rui , Cai Xiang‐Hai , Zheng Yong‐Tang , Luo Xiao‐Dong 
Published: December 2010

AbstractA total of 36 compounds including the new prenylated flavonoids (I) and (II) are isolated from the stem bark of Poncirus trifoliata.
ChemInform Abstract: Synthesis and Application of [1,2,5]Triazepane and [1,2,5]Oxadiazepane as Versatile Structural Units for Drug Discovery.
Authors: Suzuki Hideyuki , Utsunomiya Iwao , Shudo Koichi 
Published: December 2010

AbstractSeven‐membered saturated heterocyclic [1,2,5]triazepane and [1,2,5]oxadiazepane derivatives, e.g. (I), are synthesized as candidates for linker or terminal structural moieties for drug development.
ChemInform Abstract: Tetrahydropyridine Derivatives with Inhibitory Activity on the Production of Proinflammatory Cytokines. Part 3.
Authors: Nakao Akira , Ohkawa Nobuyuki , Nagasaki Takayoshi , Kagari Takashi , Doi Hiromi , Shimozato Takaichi , Ushiyama Shigeru , Aoki Kazumasa 
Published: December 2010

AbstractIn order to develop a new class of anti‐rheumatic drugs which inhibit production of proinflammatory cytokines such as TNFα, IL‐1β, IL‐6, and IL‐8, a series of 3‐pyridylpyrrole derivatives possessing a bicyclic tetrahydropyridine moiety at the 4‐position of the pyrrole ring are synthesized and their pharmacological activities are evaluated.
ChemInform Abstract: Design, Synthesis, and Biological Evaluation of 1,5‐Diaryl‐1,2,4‐triazole Derivatives as Selective Cyclooxygenase‐2 Inhibitors.
Authors: Jiang Bo , Zeng Yi , Li Meng‐Jie , Xu Jin‐Yi , Zhang Yong‐Na , Wang Qiu‐Juan , Sun Ni‐Yue , Lu Tao , Wu Xiao‐Ming 
Published: December 2010

AbstractThe results of biological tests show that compound (I) is a potent and selective inhibitor of COX‐2 (IC50 = 0.37 μM) being equipotent to celecoxib.
ChemInform Abstract: The Bi‐2212 Conductor and Magnet Program at the National High Magnetic Field Laboratory
Authors: Larbalestier D. , Hellstrom E. , Jiang J. , Kametani F. , LoSchiavo M. , Myers D. , Schwartz J. , Shen T. , Trociewitz U. 
Published: December 2010

AbstractReview: 8 refs.
Hermann Staudinger und der Kunstpfeffer. Ersatzgewürze
Authors: Vaupel Elisabeth 
Published: December 2010

AbstractAls während des Ersten Weltkrieges der Pfeffer, das beliebteste Scharfstoffgewürz der Deutschen, knapp wurde, synthetisierte Hermann Staudinger, der Chemie‐Nobelpreisträger des Jahres 1953, in Zusammenarbeit mit Paul Immerwahr einen Piperin‐ähnlichen Scharfstoff. Auf indifferente Füllstoffe aufgetragen, kam er zwischen 1917–1923 und abermals zwischen 1940–1948 als “Kunstpfeffer” in den Handel. Als nach Kriegsende wieder Naturpfeffer zur Verfügung stand, wurde die Herstellung des qualitativ schlechten, teuren Ersatzpfeffers eingestellt. Trotz der auf die Kriegs‐ und frühen Nachkriegsjahre beschränkten Produktion verschiedener Ersatzgewürze hatte die Suche nach entsprechenden Synthesen zur Herstellung einzelner Duftstoffe einen entscheidenden Einfluss auf die sich allmählich entwickelnde Aromastoffindustrie.
Die Chemie hinter den komplexen Molekülen
Authors: Welter Kira 
Published: December 2010

AbstractDer Nobelpreis für Chemie 2010 geht an drei Wissenschaftler, die maßgebliche Methoden entwickelt haben, mit denen unter milden Bedingungen die Synthese hochkomplexer organischer Moleküle gelingt. Der US‐Amerikaner Richard F. Heck und die Japaner Ei‐ichi Negishi und Akira Suzuki erhalten die Auszeichnung für die Entwicklung der Palladium‐katalysierten Kreuzkupplungen, die mittlerweile zu den wichtigsten Werkzeugen der modernen Synthesechemie gehören.
Kohlenstoffwaben
Authors: Harrer Roswitha 
Published: December 2010

AbstractWeil sie zweidimensionale Kohlenstoffkristalle (Graphen) zum ersten Mal isolieren und charakterisieren konnten, erhielten die beiden an der Universität von Manchester arbeitenden Russen Andre Geim und Konstantin Novoselov den Nobelpreis für Physik 2010.
Quantitative characterization of preneoplastic progression using single‐cell computed tomography and three‐dimensional karyometry
Authors: Nandakumar Vivek , Kelbauskas Laimonas , Johnson Roger , Meldrum Deirdre 
Published: December 2010

AbstractThe development of morphological biosignatures to precisely characterize preneoplastic progression necessitates high‐resolution three‐dimensional (3D) cell imagery and robust image processing algorithms. We report on the quantitative characterization of nuclear structure alterations associated with preneoplastic progression in human esophageal epithelial cells using single‐cell optical tomography and fully automated 3D karyometry. We stained cultured cells with hematoxylin and generated 3D images of individual cells by mathematically reconstructing 500 projection images acquired using optical absorption tomographic imaging. For 3D karyometry, we developed novel, fully automated algorithms to robustly segment the cellular, nuclear, and subnuclear components in the acquired cell images, and computed 41 quantitative morphological descriptors from these segmented volumes. In addition, we developed algorithms to quantify the spatial distribution and texture of the nuclear DNA. We applied our methods to normal, metaplastic, and dysplastic human esophageal epithelial cell lines, analyzing 100 cells per line. The 3D karyometric descriptors elucidated quantitative differences in morphology and enabled robust discrimination between cell lines on the basis of extracted morphological features. The morphometric hallmarks of cancer progression such as increased nuclear size, elevated nuclear content, and anomalous chromatin texture and distribution correlated with this preneoplastic progression model, pointing to the clinical use of our method for early cancer detection. © 2010 International Society for Advancement of Cytometry
A case report: Concurrent chronic myelomonocytic leukemia and T‐cell large granular lymphocytic leukemia‐type clonal proliferation as detected by multiparametric flow cytometry
Authors: Song Sophie 
Published: December 2010

AbstractBackground:Chronic myelomonocytic leukemia (CMML) is a subtype of myelodysplastic/myeloproliferative neoplasm. Although several studies have reported concurrent myelodysplastic syndrome (MDS) and T‐cell large granular lymphocytic leukemia (T‐LGL), coexistence of CMML and T‐LGL has not been characterized. We describe here a unique case of CMML plus an underlying T‐LGL‐type clonal proliferation in a patient with a long standing history of severe anemia and recent pancytopenia.Methods:Multiparametric immunophenotyping by flow cytometry was conducted using fresh peripheral blood collected in EDTA. In addition, morphologic evaluation of the peripheral blood smear and T‐cell gene rearrangement studies by polymerase chain reaction (PCR) were performed.Results:Flow cytometric analysis revealed abnormal monocytosis with multiple aberrancies including expression of cross‐lineage markers CD2 and CD56, plus reduced expression of multiple antigens. In addition, abnormal CD8+ T‐cells were identified, demonstrating dim expression of CD5 and dim to complete loss of CD7. In correlation with clinical history and morphologic review, a diagnosis of CMML plus underlying abnormal CD8+ T‐cell lymphoproliferation was made. The clonality of these abnormal T‐cells was confirmed by T‐cell gene rearrangement studies.Conclusions:We have identified a unique case of CMML in association with subclinical T‐LGL, neither of which, alone, could fully explain the clinicopathologic features identified. Our findings suggest that the coexistence of these two entities may not be coincidental, and it is likely that they may share a common pathogenic pathway related to immune‐dysregulation. © 2010 International Clinical Cytometry Society
Classical and atypical neuroblastoma— Case reports
Authors: Csáthy László , Kappelmayer János , Szegedi István , Kajtár Béla , Kiss Csongor , Hevessy Zsuzsanna 
Published: December 2010

AbstractNeuroblastoma is the most common extracranial solid tumor in early childhood with a pluripotent neural cell origin. The disease often infiltrates the bone marrow, and these cases are candidates for flow cytometric diagnosis and disease follow‐up, more so in atypical cases that are diagnostically challenging by other methods. Here, we report two neuroblastoma cases, one with characteristic neuroblastoma cells forming Homer–Wright rosettes found in the bone marrow sample by histological examination. This case showed the classical immunophenotype with CD81/CD56/CD117 positive and CD45 negative labeling and 80% bone marrow infiltration. Minimal residual disease measurement was performed in a regular fashion, and flow cytometry results showed good correlation with other disease markers. Analyzing 300,000 events provided a sensitivity level of 0.01%. The second case showed atypical cell morphology on histological examination, after which flow cytometric analysis was initiated. Atypical cells displayed CD81 and bright CD56 but CD117 negative immunophenotype, with a 28% bone marrow infiltration. In most cases the primary tumor can be identified, but in this particular case only bone marrow involvement could be detected using flow cytometry, as such making it a powerful tool for diagnosis and disease monitoring. © 2010 International Clinical Cytometry Society
Congenital acute leukemia with initial indolent presentation—A case report
Authors: Campos Lydia , Nadal Nathalie , Flandrin‐Gresta Pascale , Vasselon Christian , Aanei Carmen , Berger Claire , Stephan Jean Louis 
Published: December 2010

AbstractBackground:Congenital acute leukemia is a rare event, presenting usually as an aggressive disease with a poor prognosis. A differential diagnosis is the transient myeloproliferative disorder observed in Down syndrome. We describe the case of an apparently healthy newborn male child presenting with normal peripheral blood (PB) counts but with a blast population on differentials. The child's condition and the blast population remained unchanged during the first year of life.Methods:Bone marrow and PB were morphologically analyzed. Multiparametric flow cytometry was performed at the time of diagnosis and repeated at 1 year. These studies were completed by cytogenetic and molecular analyses.Results:Bone marrow contained 40% of undifferentiated blasts. Multiparametric flow cytometry showed low expression of CD38, HLA‐DR, and CD33 markers. All other markers were negative. Constitutional and blast cell karyotypes were normal. Fluorescence in situ hybridization analysis showed no rearrangement. Molecular studies were negative. The blast percentage remained stable during several months. After 1 year, the PB counts showed thrombocytopenia, with an increase of blast cells exhibiting the same phenotype. Clinically, an enlarged spleen was found. The child did not respond to chemotherapy and only partially to gemtuzumab ozogamicin. A cord blood cell transplantation was finally performed. With a follow‐up of 12 months, the child is doing well.Conclusions:To our knowledge, this is the first case of congenital acute leukemia with initially indolent course in a newborn without Down syndrome. This observation emphasizes the importance of a careful follow‐up. © 2010 International Clinical Cytometry Society
Variation of MDR proteins expression and activity levels according to clinical status and evolution of CML patients
Authors: Vasconcelos Flavia C. , Silva Karina L. , Souza Paloma Silva de , Silva Luiz Felipe R. , Moellmann‐Coelho Arthur , Klumb Claudete E. , Maia Raquel Ciuvalschi 
Published: December 2010

AbstractThe involvement of the multidrug resistance (MDR) mediated by ABC transporter proteins P‐glycoprotein (Pgp) and multidrug resistance‐associated protein‐1 (MRP1) overexpressions in patients with chronic myeloid leukemia (CML) are not completely understood. Pgp and MRP1 expressions and activity were analyzed in samples from 158 patients with chronic myeloid leukemia (CML). Using flow cytometry, Pgp expression was more frequently observed in early chronic (P= 0.00) and in advanced (P= 0.02) CML phases when it was compared to MRP1 expression. Variation of MDR expression and activity were observed during the CML evolution in patients previously treated with interferon and imatinib. In the K562‐Lucena cell line, Pgp positive, imatinib caused an enhancing in Pgp expression at protein and mRNA levels, whereas in the Pgp negative cell line, this drug was capable of decreasingMDR1/Pgp mRNA levels. Our result emphasizes the importance of understanding the different aspects of MDR status in patients with CML when they are under investigation in determining imatinib resistance. © 2010 International Clinical Cytometry Society
Europäischer Maßstab außenliegender Bauwerksabdichtungen am Beispiel Deutschland und Österreich
Authors: Hubner Wolfgang 
Published: December 2010

AbstractDie Bauwerksabdichtung an erdberührten Bauteilen ist im Regelfall auf die Bestandsdauer eines Bauwerkes auszulegen und kann als eine der wichtigsten Bauleistungen bezeichnet werden. Das Normenwesen in Österreich und Deutschland hat sich aufgrund der Erfahrungen aus den vergangenen Jahr(zehnt)en bis dato zu einem technisch fundierten Planungs‐ und Applikationsregelwerk entwickelt.Aus der Sicht des Autors bestehen punktuell unterschiedliche Lösungsansätze; Abweichungen in essentiellen, die Ausführungsqualität beeinflussenden Punkten, wurden dabei nicht geortet.Die ÖNORM umfasst in der Planungs‐Verfahrensnorm ÖNORM B7209 und der Werkvertragsnorm ÖNORM B2209 Teil 1 sämtliche Leistungen für Bauwerksabdichtungen, die DIN 18195 manifestiert die Leistungen der Bauwerksabdichtung in einzelnen Normexemplaren, von Teil 1 bis Teil 10.European standards for exterior waterproofing of structures: the example of Germany and Austria. As a rule, waterproofing in structures that are in physical contact with the ground has to be oriented towards the age of the structure in question and is among the most essential aspects of building works.Based on many years, even decades, of experience, standardisation in Austria and Germany now provides a well‐founded set of technical planning and application regulations. From the author’s point of view, a number of differences do exist in certain approaches, bit no relevant discrepancies can be found regarding essential points that are decisive for the quality of execution.The Austrian planning and procedural standard ÖNORM B7209 and the standard on works contracts (ÖNORM B2209, Part 1) include all works relevant for the field of waterproofing of buildings, and in the case of German standards, this matter is treated in DIN 18195, Parts 1 through 10.
Design of Unreinforced Masonry According to the Canadian Standards
Authors: Korany Yasser 
Published: December 2010

AbstractThe Canadian standard CSA S304.1‐04 provides provisions for the structural design of unreinforced, reinforced, prestressed, and prefabricated masonry structures and for ‐ masonry components such as beams, walls, columns, and pilasters in accordance with the requirements of the National Building Code of Canada. The Canadian standard prescribes the limit states design method for all types of masonry construction. An empirical design approach is permitted for unreinforced masonry. In this article, an overview of the provisions of CSA S304.1‐04 pertaining to the design of unreinforced masonry structures is presented.Bemessung von unbewehrtem Mauerwerk nach der Kanadischen Norm. Die kanadische Norm CSA S304.1‐04 enthält Festlegungen zur ingenieurmäßigen Bemessung von unbewehrten, bewehrten, vorgespannten und vorgefertigten Mauerwerkkonstruktionen und für Mauerwerksbauteile wie Balken, Wände, Pfeiler und Pilaster in Übereinstimmung mit der kanadischen Bauordnung. Die nationalen Bauvorschriften fordern die Anwendung der Methode der Grenzzustände für alle Arten von Mauerwerkkonstruktionen. Eine empirische Bemessungsmethode ist für unbewehrtes Mauerwerk zugelassen. In dem vorliegenden Beitrag wird ein Überblick über die Kanadische Bemessungsnorm im Hinblick auf die Bemessung von unbewehrtem Mauerwerk gegeben.Der Beitrag stellt die meisten, jedoch nicht alle Festlegungen zur ingenieurmäßigen Bemessung von unbewehrtem Mauerwerk vor. Interessierte Leser können in den angegebenen Quellen weitere Informationen und Ausführungen dazu finden. Der Leser sei aber auch darauf hingewiesen, dass die kanadische Norm weitere Festlegungen zur ingenieurmäßigen Bemessung von bewehrtem, vorgespanntem und vorgefertigtem Mauerwerk enthält. Die diese Art von Mauerwerk betreffenden Passagen werden hier nicht vorgestellt.
Voltammetric determination of promethazine hydrochloride at a multi‐wall carbon nanotube modified glassy carbon electrode
Authors: Xi Xia , Ming Liang , Liu Jie 
Published: December 2010

AbstractA simple and sensitive method is described for voltammetric determination of promethazine hydrochloride (PMZ), a widely used phenothiazine drug, based on its electrochemical oxidation at a multi‐wall carbon nanotube (MWCNT) modified glassy carbon electrode (GCE). Compared with bare GCE, the MWCNT‐modified GCE exhibited excellent enhancement effect on the electrochemical oxidation of PMZ. PMZ yielded two anodic peaks at about 0.61 V and 0.78 V, and the peak at 0.61 V was applied to the determination. Under optimized conditions, the anodic peak current was linear to the concentration of PMZ in the range from 5.0 × 10−8 to 4.0 × 10−4 M with the detection limit of 1.0 × 10−8 M. The relative standard deviation (RSD) was 2.28% for 8.0 × 10−6 M PMZ (n = 10). To further validate its possible application, the proposed method was successfully used for the quantification of PMZ in pharmaceutical formulations and biological fluids with satisfactory results. Copyright © 2010 John Wiley & Sons, Ltd.
Stable, conditional, and muscle‐fiber‐specific expression of electroporated transgenes in chick limb muscle cells
Authors: Wang Hui , Bonnet Aline , Delfini Marie Claire , Kawakami Koichi , Takahashi Yoshiko , Duprez Delphine 
Published: December 2010

AbstractLimb muscle formation is spread out over time and, consequently, muscle cells are not easy to target at any particular stages. We aimed to design a technique to study gene function in the different steps of limb muscle formation. We have associated transposon‐mediated gene transfer and a tetracycline‐dependent activation method with forelimb somite electroporation. In addition, we have established a new vector combining a differentiated‐muscle‐cell‐specific promoter and the transposon system, which allows stable gene expression in limb differentiated muscle cells and not in muscle progenitors. Using these methods, we observed that conditional Fgf4 expression in muscle cells at the onset of fetal muscle differentiation and specific Fgf4 expression in differentiated muscle cells alter muscle fiber formation in chick limbs. Limb somite electroporation with these set of vectors allowing stable, conditional, and differentiated‐muscle‐specific expression of transgenes opens new perspectives for investigating gene function at various steps of limb muscle formation. Developmental Dynamics, 2011. © 2010 Wiley‐Liss, Inc.
Fgfr1 and the IIIc isoform of Fgfr2 play critical roles in the metanephric mesenchyme mediating early inductive events in kidney development
Authors: Sims‐Lucas Sunder , Cusack Brian , Baust Jeffrey , Eswarakumar Veraragavan P. , Masatoshi Hagiwara , Takeuchi Akihide , Bates Carlton M. 
Published: December 2010

AbstractFibroblast growth factor receptors (Fgfrs) have critical roles in kidney development. FgfrIIIb is thought to act in epithelium, while FgfrIIIc functions in mesenchyme. We aimed to determine roles of Fgfr2IIIc in kidney development. Mice with deletion of Fgfr2IIIc (Fgfr2IIIc−/−) had normal kidneys. Combination of Fgfr2IIIc−/− with conditional deletion of Fgfr1 in metanephric mesenchyme (MM) (Fgfr1Mes−/−Fgfr2IIIc−/−) had small but identifiable MM at embryonic day (E) 10.5, expressing mesenchymal markers including Eya1, Six2, Pax2, and Gdnf (unlike Fgfr1/2Mes−/− mice that have no obvious MM). E11.5 Fgfr1Mes−/−Fgfr2IIIc−/− mice had rudimentary MM expressing only Eya1. Control, Fgfr2IIIc−/−, and Fgfr1Mes−/−Fgfr2IIIc−/− kidney mesenchymal tissues also express Fgfr2IIIb. In ureteric lineages, E10.5 Fgfr1Mes−/−Fgfr2IIIc−/− embryos had ureteric outgrowth (sometimes multiple buds); however, by E11.5 Gdnf absence lead to no ureteric elongation or branching (similar to Fgfr1/2Mes−/− mice). Beyond E12.5, Fgfr1Mes−/−Fgfr2IIIc−/− mice had no renal tissue. In conclusion, Fgfr2IIIc and Fgfr1 in kidney mesenchyme (together) are critical for normal early renal development. Developmental Dynamics, 2011. © 2010 Wiley‐Liss, Inc.