bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of first‐trimester ultrasound in the diagnosis of early embryonic demise: a systematic review
Authors: Jeve Y. , Rana R. , Bhide A. , Thangaratinam S. 
Published: October 2011

AbstractObjectivesTo evaluate, by systematic review of the literature, the accuracy of first‐trimester ultrasound in diagnosing early embryonic demise.MethodsWe searched MEDLINE (1951–2011), Embase (1980–2011) and the Cochrane Library (2010) for relevant citations. The reference lists of all known primary and review articles were examined. Language restrictions were not applied. Studies which evaluated the accuracy of first‐trimester ultrasonography in pregnant women for the diagnosis of early embryonic demise were selected in a two‐stage process and their data extracted by two reviewers. Accuracy measures including sensitivity, specificity and likelihood ratios (LRs) for abnormal and normal test results were calculated for each study and for each test threshold.ResultsEight primary articles with four test categories (18 2 × 2 tables), involving 872 women, evaluated the accuracy of ultrasound in diagnosing early embryonic demise. The lower limit of the 95% CI for specificity was > 0.95 in only two tests. These were an empty gestational sac with mean diameter of ≥ 25 mm and absent yolk sac with a mean gestational sac diameter of ≥ 20 mm (specificity, 1.00; 95% CI, 0.96–1.00 for both).ConclusionsThere is a paucity of high‐quality, prospective data on which to base guidelines for the accurate diagnosis of early pregnancy demise. The findings are limited by the small number of studies and patients, the age of the studies, inclusion of symptomatic and asymptomatic women and variable reference standards for diagnosis of early pregnancy demise. Before guidelines for the safe management of threatened miscarriage can be formulated, there is an urgent need for an appropriately powered, prospective study using current ultrasound technology and an agreed reference standard for pregnancy success or loss. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Interhospital Transfers of Acute Care Surgery Patients: Should Care for Nontraumatic Surgical Emergencies be Regionalized?
Authors: Santry Heena P. , Janjua Sumbal , Chang Yuchiao , Petrovick Laurie , Velmahos George C. 
Published: October 2011

AbstractBackgroundPatients with major nontraumatic surgical emergencies (NTSEs) are commonly transferred from small hospitals to tertiary care centers. We hypothesized that transferred patients (TRANS) have worse outcomes than patients with similar diagnoses admitted directly to a tertiary center (DIRECT).MethodsWe reviewed all patients admitted to the acute care surgery service of our tertiary center (September 1, 2006–October 31, 2009) with one of eight diagnoses indicating a major NTSE. Patients transferred for reasons other than the severity of illness were excluded. Univariate and multivariable analyses compared TRANS and DIRECT patients.ResultsOf 319 patients eligible for analysis, 103 (34%) were TRANS and averaged 3.8 days in the referring hospital before transfer. Compared to DIRECT patients, TRANS patients were more likely to be obese (18.5 vs. 8.0%, P = 0.006) and have cardiac (24 vs. 14%, P = 0.022) or pulmonary (25 vs. 12%, P = 0.003) co‐morbidities. TRANS patients were also more likely to present to the tertiary center with hypotension (9 vs. 2%, P = 0.021), tachycardia (20 vs. 13%, P = 0.036), anemia (83 vs. 58%, P < 0.001), and hypoalbuminemia (50 vs. 14%, P < 0.001). TRANS patients had higher mortality (4.9 vs. 0.9%, P = 0.038) and longer hospital stay (8 with 5–13 days vs. 5 with 3–8 days, P < 0.001).ConclusionsTRANS patients comprised a significant portion of the population with major NTSEs admitted to the acute care surgery service of our tertiary center. They presented with greater physiologic derangement and had worse outcomes than DIRECT patients. As is currently established for trauma care, regionalization of care for NTSEs should be considered.
Point mutation instability (PIN) mutator phenotype as model for true back mutations seen in hereditary tyrosinemia type 1 – a hypothesis
Authors: van Dyk Etresia , Pretorius Pieter J. 
Published: October 2011

AbstractHereditary tyrosinemia type 1 (HT1) is an autosomal recessive disorder affecting fumarylacetoacetate hydrolase (FAH), the last enzyme in the tyrosine catabolism pathway. The liver mosaicism observed in HT1 patients is due to the reversion to the wild type of one allele of the original point mutation in fah. It is generally accepted that these reversions are true back mutations; however, the mechanism is still unresolved. Previous reports excluded intragenic recombination, mitotic recombination, or homologous recombination with a pseudogene as possible mechanisms of mutation reversion in HT1. Sequence analysis did not reveal DNA motifs, tandem repeats or other sequence peculiarities that may be involved in mutation reversion. We propose the hypothesis that a point mutation instability mutator (PIN) phenotype brought about by the sustained stress environment created by the accumulating metabolites in the cell is the driver of the true back mutations in HT1. The metabolites accumulating in HT1 create a sustained stress environment by activating the extracellular signal‐regulated kinase (ERK) and AKT survival pathways, inducing aberrant mitosis and development of death resistant cells, depleting glutathione, and impairing DNA ligase IV and possibly DNA polymerases δ and ε. This continual production of proliferative and stress‐related survival signals in the cellular environment coupled with the mutagenicity of FAA, may instigate a mutator phenotype and could end in tumorigenesis and/or mutation reversion. The establishment of a PIN‐mutator phenotype therefore not only seems to be a possible mechanism underlying the true back mutations, but also contributes to explaining the clinical heterogeneity seen in hereditary tyrosinemia type 1.
Trends in Telehealth versus On‐site Clinical Genetics Appointments in Manitoba: A Comparative Study
Authors: Elliott Alison M. , Mhanni Aizeddin A. , Marles Sandra L. , Greenberg Cheryl R. , Chudley Albert E. , Nyhof Gwendolyne C. , Chodirker Bernard N. 
Published: October 2011

AbstractTelehealth involves the use of information and communications technology to deliver health services to patients over distance. Canada is well suited to benefit from telehealth since many individuals live in remote, rural and isolated locations. Manitoba is the easternmost prairie province and MBTelehealth is an active Canadian program that currently has 105 sites in 73 communities. Although studies of patient satisfaction comparing telehealth to on‐site clinical visits have been conducted, a comparative study of the types of genetics patients seen via these two modalities has not been performed previously. In this study we: (1) examined the uptake of telehealth in Genetics in Manitoba; (2) contrasted telehealth usage in Genetics with other clinical programs; and (3) performed a comparative study of the types of Genetics referrals seen in 2008 on‐site versus via telehealth. Results indicate the uptake of telehealth is increasing and has made genetics outreach clinics unnecessary. The Program of Genetics and Metabolism is consistently one of the top ten utilizers of telehealth within the province. With respect to discipline, chi square analysis revealed the trends were not significantly different for on‐site and telehealth encounters, with prenatal referrals being the most common and Hereditary Breast and Ovarian Cancer referrals being the least common. Referrals within each discipline varied depending on the need for fetal assessment and physical examination. Telehealth was utilized regularly for test results sessions across all disciplines.
Long waves through emergent coastal vegetation
Authors: Mei Chiang C. , Chan I-Chi , Liu Philip L.-F. , Huang Zhenhua , Zhang Wenbin 
Published: October 2011

AbstractWe study the effects of emergent coastal forests on the propagation of long surface waves of small amplitude. The forest is idealized by an array of vertical cylinders. Simple models are employed to represent bed friction and to simulate turbulence generated by flow through the tree trunks. A multi-scale (homogenization) analysis similar to that for seepage flows is carried out to deduce the effective equations on the macro-scale. The effective coefficients are calculated by numerically solving the micro-scale problem in a unit cell surrounding one or several cylinders. Analytical and numerical solutions for wave attenuation on the macro-scale for different bathymetries and coastal forest configurations are presented. For a transient incident wave, analytical results are discussed for the damping of a leading tsunami. For comparison series of laboratory data for periodic and transient incident waves are also presented. Good agreement is found even though some of the measured waves are short or nonlinear.
Linear stability of double-diffusive two-fluid channel flow
Authors: Chandra Sahu Kirti , Govindarajan Rama 
Published: October 2011

AbstractDouble-diffusive density stratified systems are well studied and have been shown to display a rich variety of instability behaviour. However double-diffusive systems where the inhomogeneities in solute concentration are manifested in terms of stratified viscosity rather than density have been studied far less and, to the best of the authors’ knowledge, not in high-Reynolds-number shear flows. In a simple geometry, namely the two-fluid channel flow of such a system, we find a new double-diffusive mode of instability. The instability becomes stronger as the ratio of diffusivities of the two scalars increases, even in a situation where the net Schmidt number decreases. The double-diffusive mode is destabilized when the layer of viscosity stratification overlaps with the critical layer of the perturbation.
A systematic review and meta-regression analysis of the vitamin D intake–serum 25-hydroxyvitamin D relationship to inform European recommendations
Authors: Cashman Kevin D. , Fitzgerald Anthony P. , Kiely Mairead , Seamans Kelly M. 
Published: October 2011

The present study used a systematic review approach to identify relevant randomised control trials (RCT) with vitamin D and then apply meta-regression to explore the most appropriate model of the vitamin D intake–serum 25-hydroxyvitamin D (25(OH)D) relationship to underpin setting reference intake values. Methods included an updated structured search on Ovid MEDLINE; rigorous inclusion/exclusion criteria; data extraction; and meta-regression (using different model constructs). In particular, priority was given to data from winter-based RCT performed at latitudes >49·5°N (n12). A combined weighted linear model meta-regression analyses of natural log (Ln) total vitamin D intake (i.e. diet and supplemental vitamin D)v. achieved serum 25(OH)D in winter (that used by the North American Dietary Reference Intake Committee) produced a curvilinear relationship (mean (95 % lower CI) serum 25(OH)D (nmol/l) = 9·2 (8·5) Ln (total vitamin D)). Use of non-transformed total vitamin D intake data (maximum 1400 IU/d; 35 μg/d) provided for a more linear relationship (mean serum 25(OH)D (nmol/l) = 0·044 × (total vitamin D)+33·035). Although inputting an intake of 600 IU/d (i.e. the RDA) into the 95 % lower CI curvilinear and linear models predicted a serum 25(OH)D of 54·4 and 55·2 nmol/l, respectively, the total vitamin D intake that would achieve 50 (and 40) nmol/l serum 25(OH)D was 359 (111) and 480 (260) IU/d, respectively. Inclusion of 95 % range in the model to account for inter-individual variability increased the predicted intake of vitamin D needed to maintain serum 25(OH)D ≥ 50 nmol/l to 930 IU/d. The model used to describe the vitamin D intake–status relationship needs to be considered carefully when setting new reference intake values in the Europe.
Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma
Authors: Jan Ren-Long , Yeh Kung-Chih , Hsieh Miao-Hsi , Lin Yen-Lin , Kao Hui-Fang , Li Pi-Hsueh , Chang Yuh-Shin , Wang Jiu-Yao 
Published: October 2011

Probiotics are normal inhabitants of the gastrointestinal tract of man and are widely considered to exert a number of beneficial effects in many diseases. But the mechanism by which they modulate the immune system is poorly understood. The present study was planned to explore the anti-allergic effect of Lactobacillus gasseri on a mouse model of allergic asthma. Dermatophoides pteronyssinus (Der p) sensitised and challenged BALB/c mice were orally administered via oral administration with three different doses of L. gasseri (low, 1 × 106 colony-forming units (CFU); medium, 2 × 106 CFU; high, 4 × 106 CFU), in 700 μl of PBS daily, starting from 2 weeks before Der p sensitisation for 4 weeks. After the allergen challenge, airway responsiveness to methacholine, influx of inflammatory cells to the lung, and cytokine levels in bronchoalveolar lavage (BAL) fluids and splenocytes culture were assessed. Our results showed that oral administration of a high dose of L. gasseri (4 × 106 CFU) decreased airway responsiveness to methacholine, attenuated the influx of inflammatory cells to the airways and reduced the levels of TNF-α, thymus and activation-regulated chemokine (TARC) and IL-17A in BAL fluids of Der p-sensitised and -challenged mice. Moreover, L. gasseri decreased IL-17A production in transforming growth factor-α and IL-6 stimulated splenocytes and cell numbers of IL-17 producing alveolar macrophages in L. gasseri-treated mice as compared to non-treated, Der p-sensitised and -challenged mice. In conclusion, oral administration with L. gasseri can attenuate major characteristics of allergen-induced airway inflammation and IL-17 pro-inflammatory immune response in a mouse model of allergic asthma, which may have clinical implication in the preventive or therapeutic potential in allergic asthma.
Regime shifts and heterogeneous trends in malaria time series from Western Kenya Highlands
Authors: CHAVES LUIS FERNANDO , HASHIZUME MASAHIRO , SATAKE AKIKO , MINAKAWA NOBORU 
Published: October 2011

SUMMARYLarge malaria epidemics in the East African highlands during the mid and late 1990s kindled a stream of research on the role that global warming might have on malaria transmission. Most of the inferences using temporal information have been derived from a malaria incidence time series from Kericho. Here, we report a detailed analysis of 5 monthly time series, between 15 and 41 years long, from West Kenya encompassing an altitudinal gradient along Lake Victoria basin. We found decreasing, but heterogeneous, malaria trends since the late 1980s at low altitudes (<1600 m), and the early 2000s at high altitudes (>1600 m). Regime shifts were present in 3 of the series and were synchronous in the 2 time series from high altitudes. At low altitude, regime shifts were associated with a shift from increasing to decreasing malaria transmission, as well as a decrease in variability. At higher altitudes, regime shifts reflected an increase in malaria transmission variability. The heterogeneity in malaria trends probably reflects the multitude of factors that can drive malaria transmission and highlights the need for both spatially and temporally fine-grained data to make sound inferences about the impacts of climate change and control/elimination interventions on malaria transmission.
Defending normativism
Authors: Hrotic Steven 
Published: October 2011

AbstractElqayam & Evans (E&E) argue that evaluative normativism leads to unacceptable research biases, and should be avoided. Though it is stipulated that the particular biases they discuss are cause for concern, this argument should not be generalized. The boundary between evaluative and goal-directed “directive” norms is difficult to define, and normative assumptions are an integral part of academic progress; moreover, the biases that result may have beneficial potential.
Dynamical properties of the negative beta-transformation
Authors: LIAO LINGMIN , STEINER WOLFGANG 
Published: October 2011

AbstractWe analyse dynamical properties of the negative beta-transformation, which has been studied recently by Ito and Sadahiro. Contrary to the classical beta-transformation, the density of the absolutely continuous invariant measure of the negative beta-transformation may be zero on certain intervals. By investigating this property in detail, we prove that the (−β)-transformation is exact for all β>1, confirming a conjecture of Góra, and intrinsic, which completes a study of Faller. We also show that the limit behaviour of the (−β)-expansion of 1 when β tends to 1 is related to the Thue–Morse sequence. A consequence of the exactness is that every Yrrap number, which is a β>1 such that the (−β) -expansion of 1 is eventually periodic, is a Perron number. This extends a well-known property of Parry numbers. However, the set of Parry numbers is different from the set of Yrrap numbers.
The uncertain (re)politicisation of fiscal relations in Europe: a shift in EMU's modes of governance
Authors: PAUDYN BARTHOLOMEW 
Published: October 2011

AbstractEurope's numerous fiscal crises – 2003 Stability and Growth Pact (SGP) crisis, its subsequent 2005 reforms, and the recent sovereign debt woes – draw attention to a shift in the management of EMU; namely the inclusion of more uncertainty-based governance. Understood as modalities of government, risk, and uncertainty make the production of this fiscal-monetary space intelligible as a recognised form of knowledge and object of government. Whereas the Pact was devised as the anchor for EMU, it has come to symbolise its weakness. This article argues that the result is an antagonistic relationship between the programmatic and operational dimensions of fiscal governance; otherwise seen as a dialectic between the two competing domains of expertise/law and politics. Starting with the 2005 SGP reforms, and exacerbated by the credit crisis, uncertainty has been mobilised to justify alternative forms of managing fiscal conduct linked to new strategies of calculation and issues of responsibility. Bound to variegated notions of ‘fiscal normality’, I contend that the 2005 reforms signal the (re)politicisation of the budgetary framework and the reconfiguration of the politics of limits. Rather than marginalising informal judgment, the government through uncertainty places a greater emphasis on creative entrepreneurialism in fostering compliance in ways risk does not.
Learning the forward kinematics behavior of a hybrid robot employing artificial neural networks
Authors: Kang Rongjie , Chanal Hélène , Bonnemains Thomas , Pateloup Sylvain , Branson David T. , Ray Pascal 
Published: October 2011

SUMMARYHybrid robots, composed of a parallel platform and serial wrist, achieve a compromise of stiffness and dexterity. Thus, they are well suited for applications such as aircraft component machining and automotive assembly, where high accuracy and large workspace movements are required. However, their forward kinematics can be highly coupled and be nonlinear. To reduce the time required to define the forward kinematics of a robot with parallel–serial structure, this paper introduces the use of neural networks. Two radial basis function networks are trained to learn the parallel and serial kinematics separately, and then integrated into a complete model. The error of this network model is analyzed and identified by a particle swarm optimization algorithm. Simulation and experiment results are obtained from the hybrid robot, Exechon, which shows that the developed kinematic model is able to produce accurate position and orientation estimates of the end-effector. The computation time of the neural network model is greatly reduced when compared to the time achieved by the numerical model.
Estimation and Mitigation of the Main Errors for Centimetre-level Compass RTK Solutions over Medium-Long Baselines
Authors: Guo Hairong , He Haibo , Li Jinlong , Wang Aibing 
Published: October 2011

Centimetre-level RTK solutions are mainly influenced by satellite orbit errors, ionospheric and tropospheric delays, and measurement noise (including multipath effects). Estimation and mitigation of the main errors for the CM-level Compass RTK solutions over medium-long baselines are investigated. Tests conducted for this research lead to the following conclusions:
1.For 100 km baselines, a 4 cm error in height component will be induced by a 10 m orbit error. For longer baselines, rapid precise ephemeris will be needed for CM-level accuracy RTK solutions.2.The residual ionospheric delay error can be eliminated using the optimal triple-frequency ionosphere-free linear combination with the coefficients of 2·6087, −0·5175 and −1·0912 respectively for observations on f1, f2 and f3 frequencies. This combination is optimal in terms of its noise level, e.g., the noise is only amplified three times. It can be used for high accuracy RTK positioning.3.The residual tropospheric delay can be resolved for the introduced relative zenith tropospheric delay (RZTD) parameters.It is shown that the RTK solutions estimated from the least squares (LS) with the RZTD parameters are worse than that without these parameters. For instance, the errors in the height components are amplified approximately three times, which may be caused by the strong correlation between the introduced RZTD parameters and the height components. However, considering the fact that the residual zenith tropospheric delays vary slowly with time and the variation can be assumed to follow a random walk process, the RTK solutions can be improved using the Kalman filter and a priori information for the RZTD parameters.
Dementelcoach: effect of telephone coaching on carers of community-dwelling people with dementia
Authors: van Mierlo Lisa D. , Meiland Franka J. M. , Dröes Rose-Marie 
Published: October 2011

ABSTRACTBackground: Dementelcoach is a new telephone intervention to support informal caregivers of community-dwelling people with dementia. The effectiveness of this intervention was evaluated on burden and mental health problems of informal caregivers.Methods: A pre-test/post-test comparison group design was used with three groups of informal caregivers. Two of the groups were experimental and received either (1) telephone coaching or (2) telephone coaching in combination with respite care (psychogeriatric day care); the third was a comparison group which received day care only. Telephone coaching was offered by trained coaches once every two to three weeks over a period of 20 weeks.Results: Informal caregivers who received telephone coaching in combination with respite care reported significantly less burden compared to caregivers who received telecoaching only, and they experienced significantly fewer mental health problems than those who received day care only.Conclusion: Telecoaching according to the principles of Dementelcoach combined with respite care (psychogeriatric day care) is more effective in reducing burden and health complaints in informal caregivers of community-dwelling people with dementia than telecoaching or day care only.