bluuebunny/crossref_metadata_2025_split huggingface dataset:
New US deposit insurance rules for trust accounts take effect
Authors: Matusic Marla , Bisanz Matthew , Clements Ross , Leong Marc 
Published: April 2024

Abstract
On 1 April 2024, new requirements for US bank deposit insurance coverage for trust accounts took effect. These requirements apply to insured depository institutions, which include the over 4,500 US banks and similar organizations that are chartered under US law and hold deposits that are insured by the Federal Deposit Insurance Corporation. The new requirements apply retroactively to existing trust accounts, and some individuals may be entitled to more or less deposit insurance coverage than under existing requirements. Further, US-based banks that offer certificates of deposit (CDs), including structured CDs, to investors should be aware of how the new requirements affect their trust account clients’ deposit insurance and investment strategies and should update their program disclosures accordingly.
Can Discussions about Girls’ Education Improve Academic Outcomes? Evidence from a Randomized Development Project
Authors: Cotton Christopher S , Nordstrom Ardyn , Nanowski Jordan , Richert Eric 
Published: April 2024

Abstract
This article evaluates the impact that facilitated discussions about girls’ education have on education outcomes for students in rural Zimbabwe. The staggered implementation of components of a randomized education project allowed for the causal analysis of a dialogue-based engagement campaign. This campaign involved regular discussions between trained facilitators and parents, teachers, and youth about girls’ rights, the importance of attending school, and the barriers girls face in pursuing education. The campaigns increased mathematics performance and enrollment in the year after implementation. There was no similar improvement in literacy performance during this period. Longer-term data on the broader project suggest that adding additional education-focused interventions did not further increase mathematics performance and enrollment beyond what can be attributable to the dialogue campaigns alone.
Temporal trend in mortality due to congenital heart disease in China from 2008 to 2021
Authors: Tian Youping , Hu Xiaojing , Gu Qing , Yang Miao , Jia Pin , Ma Xiaojing , Ge Xiaoling , Zhao Quming , Liu Fang , Ye Ming , Yan Weili , Huang Guoying 
Published: April 2024

Abstract

Background:
Congenital heart disease (CHD) is a leading cause of birth defect-related mortality. However, more recent CHD mortality data for China are lacking. Additionally, limited studies have evaluated sex, rural–urban, and region-specific disparities of CHD mortality in China.

Methods:
We designed a population-based study using data from the Dataset of National Mortality Surveillance in China between 2008 and 2021. We calculated age-adjusted CHD mortality using the sixth census data of China in 2010 as the standard population. We assessed the temporal trends in CHD mortality by age, sex, area, and region from 2008 to 2021 using the joinpoint regression model.

Results:
From 2008 to 2021, 33,534 deaths were attributed to CHD. The period witnessed a two-fold decrease in the age-adjusted CHD mortality from 1.61 to 0.76 per 100,000 persons (average annual percent change [AAPC] = −5.90%). Females tended to have lower age-adjusted CHD mortality than males, but with a similar decline rate from 2008 to 2021 (females: AAPC = −6.15%; males: AAPC = −5.84%). Similar AAPC values were observed among people living in urban (AAPC = −6.64%) and rural (AAPC = −6.12%) areas. Eastern regions experienced a more pronounced decrease in the age-adjusted CHD mortality (AAPC = −7.86%) than central (AAPC = −5.83%) and western regions (AAPC = −3.71%) between 2008 and 2021. Approximately half of the deaths (46.19%) due to CHD occurred during infancy. The CHD mortality rates in 2021 were lower than those in 2008 for people aged 0–39 years, with the largest decrease observed among children aged 1–4 years (AAPC = −8.26%), followed by infants (AAPC = −7.01%).

Conclusions:
CHD mortality in China has dramatically decreased from 2008 to 2021. The slower decrease in CHD mortality in the central and western regions than in the eastern regions suggested that public health policymakers should pay more attention to health resources and health education for central and western regions.
Clinical Characteristics, Management, and Outcomes in Cardiogenic Shock: Insights From a High-Volume Italian Cardiac Intensive Care Unit
Authors: Del Buono Marco Giuseppe , La Vecchia Giulia , D'Aiello Alessia , Pedicino Daniela , Pinnacchio Gaetano , Genuardi Lorenzo , Montone Rocco Antonio , Saponara Gianluigi , Di Renzo Antonio , Conte Cristina , Cribari Francesco , Moroni Francesco , Filomia Simone , Brecciaroli Mattia , Aurigemma Cristina , Liuzzo Giovanna , Trani Carlo , Burzotta Francesco , Sanna Tommaso 
Published: April 2024

Abstract:Cardiogenic shock (CS) is a life-threatening condition. The aim of this study is to evaluate the clinical characteristics, management, and complication rate of patients with CS admitted to a high-volume hospital in Italy. We retrospectively reviewed the clinical, echocardiographic, and laboratory data, therapeutic management, and outcomes of patients with CS admitted to the Policlinico Gemelli (Rome) between January 1, 2020, and January 1, 2023. We included 96 patients [median age 71 years, interquartile range 60–79; 65 (68%) males], of whom 49 patients (51%) presented CS secondary to acute myocardial infarction and 60 (63%) with a de novo presentation of CS. Dobutamine was the most frequently used inotrope and noradrenaline the most frequently used vasopressor (adopted in 56% and 82% of cases, respectively). Forty-five (47%) patients died during the hospitalization. Nonsurvivors were older and had a higher inflammatory burden at admission, elevated lactate levels, a greater increase in lactate levels, higher left ventricular filling pressures, and worse right ventricular function. C-reactive protein levels [odds ratio (OR) 1.03, 95% confidence interval (CI) (1.00–1.04),P= 0.027], lactate levels at admission (OR 3.49, 95% CI, 1.59–7.63,P= 0.02), and increase in lactate levels (OR 2.8, 95% CI, 1.37–5.75,P= 0.005) were independent predictors of in-hospital all-cause death. Our data contribute to the assessment of the regional variations in the management and outcomes of patients with CS. We observed a high mortality and complication rate. Lactate acidosis and C-reactive protein measured at admission may help in identifying patients at higher risk of adverse in-hospital outcomes.
Necrotizing Fasciitis after Panniculectomy Caused by Finegoldia magna
Authors: Breidung David , Delavari Sarina , Megas Ioannis-Fivos , Reichert Bert , Billner Moritz 
Published: April 2024

Summary:
Necrotizing fasciitis is a rare yet severe complication after body contouring surgery. We present a case of a 54-year-old woman with a complex medical history who developed necrotizing fasciitis 9 days after panniculectomy and epigastric hernia repair. Microbiological examination revealed Finegoldia magna as the causative agent, a rare pathogen in necrotizing fasciitis. Patients undergoing body contouring may be at increased risk of developing necrotizing fasciitis; therefore, increased attention should be paid to this differential diagnosis in case of postoperative signs of infection. This case report highlights the pivotal importance of early recognition, prompt surgical intervention, and comprehensive medical treatment to improve patient outcomes in necrotizing fasciitis.
Neutron Activation Analysis Based on AB-BNCT Treatment Room
Authors: Cai Yunzhu , Gu Shaoxian , Wang Ningyu , Cui Fengjie , Liu Wei , Li Tianhang , Wu Zhangwen , Gou Chengjun 
Published: April 2024

Abstract
Boron neutron capture therapy (BNCT) is an ideal binary targeted radiotherapy for treating refractory tumors. An accelerator-based BNCT (AB-BNCT) neutron source has attracted more and more attention due to its advantages such as higher neutron yield in the keV energy region, less gamma radiation, and higher safety. In addition to 10B, neutrons also react with other elements in the treatment room during BNCT to produce many activation products. Due to the long half-life of some activation products, there will be residual radiation after the end of treatment and the shutdown of the accelerator, which has adverse effects on radiation workers. Therefore, the ambient dose equivalent rate in the treatment room needs to be evaluated. The AB-BNCT neutron source model proposed by Li is studied in this paper. Based on the Monte Carlo method, the Geant4 platform was used to simulate the dose induced by radionuclides near the Beam Shaping Assembly (BSA) of the source. It is concluded that the concrete wall contributed the most to the radiation dose. The dose rate of 2.45 μSv h−1 after 13 min of shutdown meets the dose rate limit of 2.5 μSv h−1, at which point it is safe for workers to enter the treatment room area.
Genetic Variants and Persistent Impairment Following Mild Traumatic Brain Injury: A Systematic Review
Authors: Feigen Chaim M. , Charney Molly F. , Glajchen Simone , Myers Cameron , Cherny Steven , Lipnitsky Ronni , Yang Wendy W. , Glassman Nancy R. , Lipton Michael L. 
Published: April 2024

Objective:
The purpose of this review is to systematically assess primary research publications on known genetic variants, which modify the risk for symptoms or dysfunction persisting 30 days or more following mild traumatic brain injury (mTBI).

Summary of Review:
A search of PubMed and Embase from inception through June 2022 identified 42 studies that associated genetic variants with the presence of symptoms or cognitive dysfunction 30 days or more following mTBI. Risk of bias was assessed for each publication using the Newcastle Ottawa Scale (NOS). Fifteen of the 22 studies evaluating apolipoprotein E (APOE) ɛ4 concluded that it was associated with worse outcomes and 4 of the 8 studies investigating the brain-derived neurotrophic factor (BDNF) reported the Val66Met allele was associated with poorer outcomes. The review also identified 12 studies associating 28 additional variants with mTBI outcomes. Of these, 8 references associated specific variants with poorer outcomes. Aside from analyses comparing carriers and noncarriers of APOE ɛ4 and BDNF Val66Met, most of the reviewed studies were too dissimilar, particularly in terms of specific outcome measures but also in genes examined, to allow for direct comparisons of their findings. Moreover, these investigations were observational and subject to varying degrees of bias.

Conclusions:
The most consistent finding across articles was that APOE ɛ4 is associated with persistent post-mTBI impairment (symptoms or cognitive dysfunction) more than 30 days after mTBI. The sparsity of other well-established and consistent findings in the mTBI literature should motivate larger, prospective studies, which characterize the risk for persistent impairment with standardized outcomes in mTBI posed by other genetic variants influencing mTBI recovery.
Candidate selection for lung transplantation – considerations beyond the medical evidence
Authors: Holm Are Martin 
Published: April 2024

Purpose of review
The scarcity of organs available for lung transplantation makes it necessary to develop consistent practices for candidate selection and organ allocation. Such policies are mainly built on prognostic estimations, which are again built on medical evidence. In addition, however, other factors also guide these practices. These factors are not always explicit. The purpose of this review is to discuss some of these factors.

Recent findings
While one candidate may be considered to be in need of a transplant, the extent to which this need is weighed up against other patients at need varies, depending on how societal responsibility is conceived at the transplant center. Individual survival benefit may be in conflict with the concept of a just distribution of life years (’fair innings’). Furthermore, the need to expand medical knowledge, and the perceived patient autonomy and right to choose may affect the selection and allocation practices. Finally, financial considerations and nationality may have great influence.

Summary
Although well trained in medical judgment, the clinicians’ candidate selection for lung transplantation is often influenced by factors beyond the medical evidence. These factors should be discussed just as transparently and accountably as the medical judgments.
Meta-analysis of modified Sijunzi decoction for the treatment of chronic atrophic gastritis
Authors: Huang Xue , Shao Shuling 
Published: April 2024

Background:
Qi deficiency in the spleen and stomach is considered to be the fundamental pathogenesis of chronic atrophic gastritis (CAG) in Traditional Chinese medicine. Spleen strengthening and Qi replenishment are the basic treatment principles. Sijunzi Decoction serves as the fundamental remedy for spleen notification and Qi replenishment.

Methods:
The Cochrane Library, China National Knowledge Infrastructure China Biology Medicine disc, VIP, Wanfang Database, Web of Science, PubMed, and Embase were retrieved for related randomized controlled trials published from the inception of the databases to June 3, 2023. Literature screening and data extraction were executed by 2 independent investigators. The Cochrane Collaboration tool was leveraged to appraise the quality of included studies. Meta-analysis was implemented utilizing Stata 15.

Results:
This analysis incorporated 32 studies with 2780 patients. The analysis results unveiled that compared to Western medicine treatment, modified Sijunzi Decoction significantly enhanced the clinical efficacy (relative risk [RR] = 1.241, 95% confidence interval [95% CI] = 1.199–1.285, P < .0001), lowered symptom scores (standardized mean difference [SMD] = −1.846, 95% CI = −2.160 to −1.532, P < .00001) and gastroscopic pathological scores (SMD = −1.122, 95% CI = −1.492 to −0.752, P < .00001), ameliorated quality of life (SMD = 4.294, 95% CI = 2.982–5.606, P < .00001), increased the Helicobacter pylori eradication rate (RR = 1.297, 95% CI = 1.035–1.625, P < .001), pepsinogen I levels (SMD = 2.615, 95% CI = 2.344–2.886, P < .00001), pepsinogen I/II ratio (SMD = 3.107, 95% CI = 2.811–3.403, P < .00001), and gastrin-17 levels (SMD = 1.004, 95% CI = 0.794–1.215, P < .00001), and reduced the incidence of adverse reactions (RR = 0.361, 95% CI = 0.235–0.556, P < .01) in individuals with CAG, with statistically significant discrepancies.

Conclusion:
Modified Sijunzi Decoction exhibited superior efficacy to conventional Western medicine in treating CAG. It was shown to improve the Helicobacter pylori eradication rate, reduce symptom scores, enhance quality of life, and improve pepsinogen-related indicators with a high safety profile.
Brain radiotherapy and anlotinib control primary cardiac angiosarcoma with metastases: A case report
Authors: Ma Ying-Ying , Li Zhi-Ke , Liao Zi-Yi , Peng Yang , Zeng Li , Ma Dai-Yuan 
Published: April 2024

Rationale:
Primary cardiac angiosarcoma (PCA) is a rare and fatal disease with a poor prognosis. Whether the survival of PCA patients can be prolonged with additional treatment following complete surgical excision is controversial.

Patient Concerns:
In this case study, a 52-year-old male complained of chest tightness and pain for 7 days before admission into the hospital. Subsequently, he revisited the hospital because of dizziness and headache.

Diagnoses:
Initially, the patient was diagnosed with PCA in the right atrium by thoracic computed tomography (CT). Palliative resection identified brain, lung, and liver metastases.

Intervention:
The patient accepted multimodal combination therapy, including first-line chemotherapy and then second-line anlotinib concurrent with brain radiotherapy and immunotherapy.

Outcome:
Although anlotinib combined with brain radiotherapy controlled the growth of intracranial lesions, progression-free survival (PFS) was only 5 months, and the overall survival (OS) was only 12 months.

Lesson:
The treatment for metastatic PCA needs an in-depth exploration.
Perforation of barium sulfate enterography in an infant: A case report
Authors: Lu Yixing , Mo Lixian , Chen Junhong , Peng Wei 
Published: April 2024

Rationale:
Barium peritonitis is an inflammatory response that occurs when barium accidentally enters the abdominal cavity during a barium test. In extreme circumstances, it has the potential to harm various organs and even result in death.

Patient concerns:
A 3-month-old infant was diagnosed with multiple organ failure after severe barium peritonitis.

Diagnosis:
Multiple organ dysfunction is associated with barium peritonitis.

Interventions:
The infant underwent surgical intervention and received ventilator support, anti-infection therapy, myocardial nutrition, liver and kidney protection, rehydration, circulation stabilization, and other symptomatic supportive care.

Outcomes:
The patient experienced clinical death after treatment and resuscitation was unsuccessful.

Lessons:
Barium enema perforation complications are uncommon, but can lead to fatal injuries with a high mortality rate. This case highlights the importance of raising awareness among clinicians about the risks of gastroenterography in infants and children and actively preventing and avoiding similar serious complications. The mortality rate can be reduced by timely multidisciplinary consultation and joint management once a perforation occurs.
Cerebrotendinous xanthomatosis with tremor as the main manifestation: A case report
Authors: Zhao Wei , Han Jie , Tao Dingbo , Zheng Hongliang 
Published: April 2024

Introduction:
Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive lipid metabolism disorder. It is caused by a defect in the sterol-27-hydroxylase gene, leading to the deposition of cholesteryl and bile alcohol in large amounts, causing a variety of clinical manifestations; however, tremor as the main manifestation of CTX has not been reported.

Patient’s concerns and clinical findings:
Herein, we report a 27-year-old woman, who developed head and body tremors at the age of 12 years. Many hospitals misdiagnosed her condition as idiopathic tremor and Parkinson disease, with a poor curative effect.

Primary diagnosis and intervention:
We diagnosed her with CTX and treated with chenodeoxycholic acid and clonazepam.

Conclusion:
The patient’s condition considerably improved. This case could help avoid misdiagnosis and mistreatment in clinical practice.
Diagnosis and treatment of malignant retroperitoneal mesothelioma: A case report
Authors: Tang Feihu , Cui Yong , Gao Yuan 
Published: April 2024

Rationale:
Malignant peritoneal mesothelioma (MPM) is a rare clinical disease. Although there are several reports describing intraperitoneal mesothelioma of the lung, liver, and intestine, retroperitoneal mesothelioma is, to our knowledge, very rare and rarely reported. In recent years, our best clinical protocols for the treatment and diagnosis of retroperitoneal mesothelioma have not been proven and the diagnosis and treatment are challenging.

Patient concerns:
A 37-year-old Chinese woman complained of bilateral low back pain for a month, with obvious symptoms of low back pain on the left side. To treat low back pain, retroperitoneal masses were found during physical examination. The patient consulted a urological specialist for further treatment.

Diagnosis:
After the operation, pathological biopsy confirmed retroperitoneal epithelioid diffuse mesothelioma.

Interventions:
After exclusion of surgical contraindications, the patient underwent laparoscopic retroperitoneal lesion resection under tracheal intubation and general anesthesia, and the operation was successful.

Outcomes:
On the tenth day after surgery, the patient vital signs were stable, and he was discharged.

Lessons:
Patients with malignant peritoneal mesothelioma may have no typical clinical symptoms, and the diagnosis is based on pathological and immunohistochemical examination. In selected patients, surgical cell reduction and intraoperative intraperitoneal heat chemotherapy have become the first choice of treatment, which can achieve ideal therapeutic effects and prolong survival.
Acute puerperal uterine inversion with successful manual transvaginal repositioning: A case report
Authors: Gao Qianqian , Jiang Hong , Jia Mengmeng , Xiong Jinqiu 
Published: April 2024

Rationale:
Uterine inversion is a rare medical condition that is categorized as puerperal and nonpuerperal. Repositioning of uterine involution can be done manually or surgically, the latter of which involves abdominal manipulation and disruption of the integrity of the uterine wall, which can lead to complications for the patient in subsequent pregnancies, such as uterine rupture.

Patient concerns:
We report a case of acute puerperal uterine inversion that was manually repositioned transvaginally. An ultrasonogram and reset schematic were also presented. A 23-year-old woman (gravida 1 para 0) was admitted to the hospital with a full-term pregnancy.

Diagnoses:
In the postpartum period, we found placental adhesions and uterine inversion into the uterine cavity, which was confirmed by bedside ultrasound.

Interventions and outcomes:
We administered analgesic, relieving uterine spasms, and antishock therapy along with manual stripping of the placenta and ultrasound-guided uterine repositioning. After successful repositioning the patient vaginal bleeding decreased rapidly and she was discharged 3 days after delivery.

Lessons:
Early recognition, antishock therapy and prompt repositioning are key in the management of puerperal uterine inversion. We hope that this case will enable clinicians to better visualize the ultrasound imaging of uterine inversion and the process of manual repositioning.
Hepatitis B Delta: assessment of the knowledge and practices of hepato-gastroenterologists practicing in non-academic settings in France
Authors: Cadranel Jean-François D. , Zougmoré Honoré T. , Efole Jean-René Ngele , Hanslik Bertrand , Causse Xavier , Rosa Isabelle , Lemaitre Caroline , Mokhtari Camélia , Baron Aurore , Thevenot Thierry , Medmoun Mourad , Smadhi Ryad , Fantognon Gildas , Remy André J. , Macaigne Gilles , Arondel Yves , Arpurt Jean-Pierre , Bellaiche Guy , Bourlière Marc , De Kerguenec Caroline , Heluwaert Frédéric , Verlynde Juliette , Halfon Philippe , Roulot Dominique , Carrier Paul , Loustaud-Ratti Véronique , Lemagoarou Tristan ,   ANGH and CREGG B-Delta Group
Published: April 2024

Background
Data on the management of Hepatitis B-Delta (HB-D) by hepatogastroenterologists (HGs) practicing in nonacademic hospitals or private practices are unknown in France.

Objective
We aimed to evaluate the knowledge and practices of HGs practicing in nonacademic settings regarding HB-D.

Methods
A Google form document was sent to those HGs from May to September 2021.

Results
A total of 130 HGs (mean age, 45 years) have participated in this survey. Among HBsAg-positive patients, Delta infection was sought in only 89% of cases. Liver fibrosis was assessed using FibroScan in 77% of the cases and by liver biopsy in 81% of the cases. A treatment was proposed for patients with >F2 liver fibrosis in 49% of the cases regardless of transaminase levels and for all the patients by 39% of HGs. Responding HGs proposed a treatment using pegylated interferon in 50% of cases, bulevirtide in 45% of cases and a combination of pegylated interferon and bulevirtide in 40.5% of cases. Among the criteria to evaluate the treatment efficacy, a decrease or a normalization of transaminases was retained by 89% of responding HGs, a reduction of liver fibrosis score for 70% of them, an undetectable delta RNA and HBsAg for 55% of them and a 2 log 10 decline in delta viremia for 62% of the cases.

Conclusion
Hepatitis Delta screening was not systematically performed in HBsAg-positive patients despite the probable awareness and knowledge of the few responders who were able to prescribe treatments of hepatitis delta.