bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular dynamics modeling of tubulin C‐terminal tail interactions with the microtubule surface
Authors: Freedman Holly , Luchko Tyler , Luduena Richard F. , Tuszynski Jack A. 
Published: August 2011

AbstractTubulin, an α/β heterodimer, has had most of its 3D structure analyzed; however, the carboxy (C)‐termini remain elusive. Importantly, the C‐termini play critical roles in regulating microtubule structure and function. They are sites of most of the post‐translational modifications of tubulin and interaction sites with molecular motors and microtubule‐associated proteins. Simulated annealing was used in our molecular dynamics modeling to predict the interactions of the C‐terminal tails with the tubulin dimer. We examined differences in their flexibility, interactions with the body of tubulin, and the existence of structural motifs. We found that the α‐tubulin tail interacts with the H11 helix of β‐tubulin, and the β‐tubulin tail interacts with the H11 helix of α‐tubulin. Tail domains and H10/B9 loops interact with each other and compete for interactions with positively‐charged residues of the H11 helix on the neighboring monomer. In a simulation in which α‐tubulin's H10/B9 loop switches on sub‐nanosecond intervals between interactions with the C‐terminal tail of α‐tubulin and the H11 helix of β‐tubulin, the intermediate domain of α‐tubulin showed more fluctuations compared to those in the other simulations, indicating that tail domains may cause shifts in the position of this domain. This suggests that C‐termini may affect the conformation of the tubulin dimer which may explain their essential function in microtubule formation and effects on ligand binding to microtubules. Our modeling also provides evidence for a disordered‐helical/helical double‐state system of the T3/H3 region of the microtubule, which could be linked to depolymerization following GTP hydrolysis. Proteins 2011; © 2011 Wiley‐Liss, Inc.
A spin‐calorics device based on La0.7Sr0.3MnO3/SrRuO3 superlattices
Authors: Ziese M. 
Published: August 2011

AbstractHigh quality La0.7Sr0.3MnO3/SrRuO3 superlattices with ultrathin individual layers were grown by pulsed laser deposition and were studied by magnetometry and magnetoresistance measurements. Depending on layer thickness and structural quality, exchange biasing could be observed both in magnetization and magnetotransport. In this regime the superlattice magnetization forms an exchange spring that leads to a reversible field dependence of the magnetoresistance and the magnetic work. It is shown that the magnetic work and the magnetocaloric effect can be tuned by the SrRuO3 layer thickness. This opens up the possibility of fabricating spin‐caloric devices from wedge‐shaped superlattices with self‐sustaining Seebeck effect. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
An arrayed nanoantenna for broadband light emission and detection
Authors: Miroshnichenko Andrey E. , Maksymov Ivan S. , Davoyan Arthur R. , Simovski Constantin , Belov Pavel , Kivshar Yuri S. 
Published: August 2011

AbstractWe suggest a broadband optical unidirectional arrayed nanoantenna consisting of equally spaced nanorods of gradually varying length. Each nanorod can be driven by near‐field quantum emitters radiating at different frequencies or, according to the reciprocity principle, by an incident light at the same frequency. Broadband unidirectional emission and reception characteristics of the nanoantenna open up novel opportunities for subwavelength light manipulation and quantum communication, as well as for enhancing the performance of photoactive devices such as photovoltaic detectors, light‐emitting diodes, and solar cells. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Verification of objective sensitivity climatologies of Mediterranean intense cyclones: test against human judgement
Authors: Garcies L. , Homar V. 
Published: August 2011

AbstractA variety of sensitivity climatologies of Mediterranean intense cyclones have been recently built owing to the growing international interest in contributing to the basic understanding and the short‐range forecasting of high‐impact weather events. The verification of these climatologies is essential to ensure the reliability of the sensitivity products and ultimately provide robust guidance to policy‐makers on plans to redefine routine observational strategies. This work tackles the arduous task of verifying the available (an adjoint‐based and two different ensemble‐based) sensitivity climatologies of Mediterranean intense cyclones. We perform Observing System Simulation Experiments (OSSE) with the WRF ARW model for 25 of the most intense Mediterranean cyclones detected in the ERA‐40 database to test the ability of each method in identifying areas where perturbations in the initial conditions derived from the sensitivity fields lead to a greater impact on the forecast of intense cyclones. For the sake of a sensible reference, the performance of the available sensitivity climatologies is tested against the judgement of an experienced severe weather meteorologist. In addition, a control measure of the background random response is also carried out. The impact on the prediction of intense Mediterranean cyclones of prescribed perturbations to the initial conditions is evaluated comparing each perturbed experiment with a control simulation. Furthermore, a quantitative study of the linearity of the evolution of the perturbations is performed using twin perturbations. Results confirm a statistically significant superior skill of the human and adjoint sensitivity fields against both ensemble sensitivity climatologies. Climatological ensemble sensitivities only show a noticeable improvement upon non‐sensitivity experiments when an ad hoc classification of cyclones is used. This reveals one fundamental limitation of the ensemble sensitivity technique in climatological mode when it is applied to rare events insufficiently sampled in the available datasets. Copyright © 2011 Royal Meteorological Society
Modified dynamic anti‐windup through deferral of activation
Authors: Sajjadi‐Kia Solmaz , Jabbari Faryar 
Published: August 2011

SUMMARYWe consider the dynamic anti‐windup design problem for linear systems with saturating actuators. The basic idea proposed here is to apply anti‐windup only when the performance of saturated system faces substantial degradation. We provide synthesis LMIs to obtain the gains of the dynamic anti‐windup compensator in a structure that delays the activation of the anti‐windup. Benefits of the proposed design method over the immediate activation of the anti‐windup are demonstrated using a well‐known example. Copyright © 2011 John Wiley & Sons, Ltd.
Robust H ∞  control of discrete‐time Markovian jump systems in the presence of incomplete knowledge of transition probabilities and saturating actuator
Authors: Wang Yijing , Sun Yunna , Zuo Zhiqiang , Chen Michael Z.Q. 
Published: August 2011

SUMMARYThis paper deals with the problem of robust H ∞  control for a class of discrete‐time Markovian jump systems subject to both actuator saturation and incomplete knowledge of transition probability. Different from the previous results where the transition probability is completely known, a more general situation where only partial information on the exact values of elements in transition probability matrix is considered. By introducing some free parameters to express the relationship for the known and the unknown elements of transition probability matrix in stability analysis, a criterion is established to guarantee the stochastic stability of the closed‐loop system as well as an H ∞  performance index. The concept of domain of attraction in mean square sense is used to analyze the closed‐loop stability, and the mode‐dependent H ∞  state‐feedback controller is designed. It is shown that, even in the absence of actuator saturation, the obtained result is less conservative than the existing one. A numerical example is provided to illustrate the effectiveness of the proposed method. Copyright © 2011 John Wiley & Sons, Ltd.
Dynamic and Static Softening of Sintered MgO‐PSZ / TRIP‐matrix Composites with up to 10 vol.‐% ZrO2
Authors: Yanina A. , Guk S. , Müller W. , Kawalla R. , Weigelt C. 
Published: August 2011

AbstractA metal matrix composite (MMC) consisting of AISI 304 austenitic stainless steel with up to 10 vol.‐% MgO‐PSZ was produced by a powder metallurgic process through sintering at 1300 °C and 1390 °C. The hot working of sintered samples was conducted between 900 °C and 1100 °C. The behaviour of softening kinetics was investigated using flow curve recording methods (dynamic softening) and the double‐hit method (static softening). The influence of the deformation parameters such as temperature, strain rate, inter‐pass time and relative density of the samples was determined. The microstructure development of the sintered composite after hot forming was determined by optical microscopy and SEM and was interpreted with the help of qualitative microstructure analysis. The results show a general acceleration of softening processes with increasing temperature and strain rate, with the addition of ZrO2 particles and a decrease in the density of composite materials. A mathematical‐physical model was developed to predict the softening behaviour and optimize the forming processes of the composite in the light of these results.
Secretory Pattern of Inhibin During Estrous Cycle and Pregnancy in African (Loxodonta africana) and Asian (Elephas maximus) Elephants
Authors: Yamamoto Yuki , Yuto Natsuki , Yamamoto Tatsuya , Kaewmanee Saroch , Shiina Osamu , Mouri Yasushi , Narushima Etsuo , Katayanagi Masayuki , Sugimura Keisuke , Nagaoka Kentaro , Watanabe Gen , Taya Kazuyoshi 
Published: August 2011

AbstractThe ovary of female elephants has multiple corpora lutea (CL) during the estrous cycle and gestation. The previous reports clearly demonstrated that inhibin was secreted from lutein cells as well as granulosa cells of antral follicles in cyclic Asian elephants. The aim of this study is to investigate the inhibin secretion during the pregnancy in African and Asian elephants. Two African elephants and two Asian elephants were subjected to this study. Circulating levels of immunoreactive (ir‐) inhibin and progesterone were measured by radioimmunoassay. Four pregnant periods of an African elephant and three pregnant periods of an Asian elephant were analyzed in this study. Circulating levels of ir‐inhibin started to increase at 1 or 2 week before the ovulation and reached the peak level 3 or 4 weeks earlier than progesterone during the estrous cycle in both African and Asian elephants. After last luteal phase, the serum levels of ir‐inhibin remained low throughout pregnancy in both an African and an Asian elephant. The mean levels of ir‐inhibin during the pregnancy were lower than the luteal phase in the estrous cycle despite high progesterone levels were maintained throughout the pregnancy. These results strongly suggest that CL secrete a large amount of progesterone but not inhibin during the pregnancy in elephants. Zoo Biol 31:511‐522, 2012. © 2011 Wiley Periodicals, Inc.
HCOC: a cost optimization algorithm for workflow scheduling in hybrid clouds
Authors: Bittencourt Luiz Fernando , Madeira Edmundo Roberto Mauro 
Published: August 2011

Abstract
Workflows have been used to represent a variety of applications involving high processing and storage demands. As a solution to supply this necessity, the cloud computing paradigm has emerged as an on-demand resources provider. While public clouds charge users in a per-use basis, private clouds are owned by users and can be utilized with no charge. When a public cloud and a private cloud are merged, we have what we call a hybrid cloud. In a hybrid cloud, the user has elasticity provided by public cloud resources that can be aggregated to the private resources pool as necessary. One question faced by the users in such systems is: Which are the best resources to request from a public cloud based on the current demand and on resources costs? In this paper we deal with this problem, presenting HCOC: The Hybrid Cloud Optimized Cost scheduling algorithm. HCOC decides which resources should be leased from the public cloud and aggregated to the private cloud to provide sufficient processing power to execute a workflow within a given execution time. We present extensive experimental and simulation results which show that HCOC can reduce costs while achieving the established desired execution time.
A primer to common major gastrointestinal post-surgical anatomy on CT—a pictorial review
Authors: Terrone Donato Gerardo , Lepanto Luigi , Billiard Jean-Sébastien , Olivié Damien , Murphy-Lavallée Jessica , Vandenbroucke Franck , Tang An 
Published: August 2011

Abstract
The post-operative abdomen can be challenging and knowledge of normal post-operative anatomy is important for diagnosing complications. The aim of this pictorial essay is to describe a few selected common, major gastrointestinal surgeries, their clinical indications and depict their normal post-operative computed tomography (CT) appearance. This essay provides some clues to identify the surgeries, which can be helpful especially when surgical history is lacking: recognition of the organ(s) involved, determination of what was resected and familiarity with the type of anastomoses used.
AORN Ergonomic Tool 6: Lifting and Carrying Supplies and Equipment in the Perioperative Setting
Authors: Waters Thomas , Baptiste Andrea , Short Manon , Plante‐Mallon Lori , Nelson Audrey 
Published: August 2011

AbstractPerioperative team members often are required to lift and carry heavy supplies and equipment into and around the OR; this includes lifting equipment such as hand tables, fluoroscopy boards, stirrups, Wilson frames, irrigation containers for lithotripsy, and heavy instrument pans. Lifting heavy objects creates considerable risk for musculoskeletal injuries to the back and shoulders. AORN Ergonomic Tool 6: Lifting and Carrying Supplies and Equipment in the Perioperative Setting can help caregivers evaluate lifting and carrying tasks and take measures to protect themselves from injury. Caregivers can use the revised National Institute for Occupational Safety and Health lifting equation to assess whether a specific lifting task can be performed safely.
Designing a Safer Process to Prevent Retained Surgical Sponges: A Healthcare Failure Mode and Effect Analysis
Authors: Steelman Victoria M. , Cullen Joseph J. 
Published: August 2011

AbstractA retained surgical sponge is a sentinel event that can result in serious negative outcomes for the patient. Current standards rely on manual counting, the accuracy of which may be suspect, yet little is known about why counting fails to prevent retained sponges. The objectives of this project were to describe perioperative processes to prevent retained sponges after elective abdominal surgery; to identify potential failures; and to rate the causes, probability, and severity of these failures. A total of 57 potential failures were identified, associated with room preparation, the initial count, adding sponges, removing sponges, the first closing count, and the final closing count. The most frequently identified causes of failures included distraction, multitasking, not following procedure, and time pressure. Most of the failures are not likely to be affected by an educational intervention, so additional technological controls should be considered in efforts to improve safety.
Measurements using 7.0 T post‐mortem magnetic resonance imaging of the scalar dimensions of the fetal brain between 12 and 20 weeks gestational age
Authors: Lin Xiangtao , Zhang Zhonghe , Teng Gaojun , Meng Haiwei , Yu Taifei , Hou Zhongyu , Fang Fang , Zang Fengchao , Liu Shuwei 
Published: August 2011

AbstractIn this study, scalar values for the fetal brain from 12 to 20 weeks gestational age were obtained. Fifty‐two fetal specimens of 12–20 weeks gestational age with an anatomically normal and developmentally appropriate central nervous system (CNS) were scanned using a 7.0 T magnetic resonance imaging (MRI) scanner. The linear biometric measurements of the brain were then determined. All the measurements (except for the interhemispheric distance) were found to increase linearly with gestational age, although each increased at a different growth rates. The 95% confidence interval for each value was obtained. These data may be considered to be a valuable reference for the assessment of normal fetal brain development in clinical settings and as a supplement to post‐mortem MRI or anatomical investigations.
Functional significance of the ATP‐binding cassette transporter B6 in hepatocellular carcinoma
Authors: Polireddy Kishore , Chavan Hemantkumar , Abdulkarim Bashar A. , Krishnamurthy Partha 
Published: August 2011

AbstractABCB6 is a mitochondrial transporter that regulates porphyrin biosynthesis. ABCB6 expression is upregulated in hepatocellular carcinoma (HCC) but the significance of this upregulation to HCC is not known. In the present study, we investigated: 1) ABCB6 expression in 18 resected human hepatocellular carcinoma (HCC) tissues and 3 human hepatoma cell lines; 2) pattern of ABCB6 expression during liver disease progression; and 3) functional significance of ABCB6 expression to HCC using the hepatoma cell line Huh7. ABCB6 expression was determined by real‐time quantitative reverse transcription‐polymerase chain reaction and western blotting. ABCB6 expression was upregulated in all the HCC specimens and the three‐hepatoma cell lines. Increased ABCB6 expression correlated with liver disease progression with the pattern of expression being HCC > cirrhosis > steatosis. Small hairpin RNA (shRNA)‐mediated knockdown of ABCB6 in Huh7 cells lead to decreased cellular proliferation and colony formation. Attenuation of ABCB6 expression did not affect Huh7 apoptosis but lead to a delay in G2/M phase of the cell cycle. In contrast, ABCB6 overexpression resulted in increased growth and proliferation of Huh7 cells. Since ABCB6 expression is induced in multiple tumor types we explored the role of ABCB6 in other cancer cells. ShRNA mediated knockdown of ABCB6 in HEK293 and K562 cells reduced cellular proliferation leading to a delay in G2/M phase, while ABCB6 overexpression promoted cell growth and proliferation. Collectively, these findings, obtained by loss of function and gain of function analysis, suggest that ABCB6 plays a role in cell growth and proliferation by targeting the cell cycle.
CERTAIN RESULTS OF REAL HYPERSURFACES IN A COMPLEX SPACE FORM
Authors: GHOSH AMALENDU 
Published: August 2011

AbstractFirst, we classify a real hypersurface of a non-flat complex space form with (i) semi-parallel T(=£ξg), and (ii) recurrent T. Next, we characterise a real hypersurface admitting the generalised η-Ricci soliton in a non-flat complex space form.
CONSTANT MEAN CURVATURE HYPERSURFACES IN SPHERES
Authors: DENG QIN-TAO , GU HUI-LING , SU YAN-HUI 
Published: August 2011

AbstractIn this paper, we first summarise the progress for the famous Chern conjecture, and then we consider n-dimensional closed hypersurfaces with constant mean curvature H in the unit sphere n+1 with n ≤ 8 and generalise the result of Cheng et al. (Q. M. Cheng, Y. J. He and H. Z. Li, Scalar curvature of hypersurfaces with constant mean curvature in a sphere, Glasg. Math. J. 51(2) (2009), 413–423). In order to be precise, we prove that if |H| ≤ ϵ(n), then there exists a constant δ(n, H) > 0, which depends only on n and H, such that if S0 ≤ S ≤ S0 + δ(n, H), then S = S0 and M is isometric to the Clifford hypersurface, where ϵ(n) is a sufficiently small constant depending on n.
DERIVED SUBGROUPS OF FIXED POINTS IN PROFINITE GROUPS
Authors: ACCIARRI CRISTINA , DE SOUZA LIMA ALINE , SHUMYATSKY PAVEL 
Published: August 2011

AbstractThe main result of this paper is the following theorem. Letqbe a prime andAbe an elementary abelian group of orderq3. Suppose thatAacts as a coprime group of automorphisms on a profinite groupGin such a manner thatCG(a)′ is periodic for eacha∈A#. ThenG′ is locally finite.
Worm morphology of Schistosoma japonicum using confocal laser scanning microscopy
Authors: Zhang Wei-na , Zhang Peng , Liu Miao , Ren Cui-ping , Jia Xue-mei , Huang Da-ke , Gui Li , Shen Ji-jia 
Published: August 2011

AbstractMale and female Schistosoma japonicum worms have dissimilar appearances in their final host. In this study, a morphometric and morphological assessment of whole worms derived from unisexual and mixed infections in mice was conducted using confocal laser scanning microscopy. Worms from mixed infections showed significant morphological changes between 15 and 25 days post-infection (PI). On the fifteenth day PI, 33% of males had formed the conspicuous gynecophoric canal, but only 8% of them had testicular lobes containing a few germinative cells; 13% of females had incipient ovaries with a few immature ovarian cells inside. On the twentieth day PI, the testicular lobes contained more germinative cells in all male worms, while female worms presented vitelline glands. On the twenty-fifth day PI, more germinative cells were observed in the male testicular lobes, and differentiated cells were present in the female ovaries. All worms had fully developed reproductive organs from 30 days PI onwards. Morphometric analysis showed significant differences between mixed and unisexual infections at 35 days PI. Ovaries of worms from unisexual infections contained cells in one stage of maturation and vitelline glands had undifferentiated cells. Our study of S. japonicum provides a detailed comparison of different morphological traits from worms of mixed and unisexual infections throughout development.
The potential for voluntary instruments to achieve conservation planning goals: the case of conservancies in South Africa
Authors: Downsborough Linda , Shackleton Charlie M. , Knight Andrew T. 
Published: August 2011

AbstractSpatial prioritizations and gap analyses are increasingly undertaken to allocate conservation resources. Most spatial prioritizations are conducted without specifying the conservation instruments to be implemented and gap analyses typically assess formally protected areas but increasingly include private land conservation instruments. We examine conservancies to see if these voluntary instruments contribute towards achieving goals of South African conservation planning initiatives. We conducted a nationwide survey and interviews with conservancy members in Gauteng and the Eastern Cape. Conservancies have potential for assisting South Africa to achieve conservation planning goals at national and local scales but their inclusion in spatial prioritizations and gap analyses predicates improved protection for nature, operational refinement and increased support. We sound a warning to conservation planning initiatives that incorporate voluntary instruments on private land, and present recommendations for strengthening such instruments to make them more effective. Our findings may assist conservation planners elsewhere to design more effective conservation planning initiatives focused on private land.