bluuebunny/crossref_metadata_2025_split huggingface dataset:
MDPV (3,4-methylenedioxypyrovalerone) administered to mice during development of the central nervous system produces persistent learning and memory impairments
Authors: Kuczyńska Katarzyna , Bartkowska Katarzyna , Djavadian Ruzanna , Zwierzyńska Ewa , Wojcieszak Jakub 
Published: May 2024

Abstract
Background
Synthetic cathinones (SC) constitute the second most frequently abused class of new psychoactive substances. They serve as an alternative to classic psychostimulatory drugs of abuse, such as methamphetamine, cocaine, or 3,4-methylenedioxymethamphetamine (MDMA). Despite the worldwide prevalence of SC, little is known about their long-term impact on the central nervous system. Here, we examined the effects of repeated exposure of mice during infancy, to 3,4-methylenedioxypyrovalerone (MDPV), a SC potently enhancing dopaminergic neurotransmission, on learning and memory in young adult mice.

Methods
All experiments were performed on C57BL/6J male and female mice. Animals were injected with MDPV (10 or 20 mg/kg) and BrdU (bromodeoxyuridine, 25 mg/kg) during postnatal days 11–20, which is a crucial period for the development of their hippocampus. At the age of 12 weeks, mice underwent an assessment of various types of memory using a battery of behavioral tests. Afterward, their brains were removed for detection of BrdU-positive cells in the dentate gyrus of the hippocampal formation with immunohistochemistry, and for measurement of the expression of synaptic proteins, such as synaptophysin and PSD95, in the hippocampus using Western blot.

Results
Exposure to MDPV resulted in impairment of spatial working memory assessed with Y-maze spontaneous alternation test, and of object recognition memory. However, no deficits in hippocampus-dependent spatial learning and memory were found using the Morris water maze paradigm. Consistently, hippocampal neurogenesis and synaptogenesis were not interrupted. All observed MDPV effects were sex-independent.

Conclusions
MDPV administered repeatedly to mice during infancy causes learning and memory deficits that persist into adulthood but are not related to aberrant hippocampal development.
Physiological and molecular bases of the nickel toxicity responses in tomato
Authors: Yu Hao , Li Weimin , Liu Xiaoxiao , Song Qianqian , Li Junjun , Xu Jin 
Published: May 2024

AbstractNickel (Ni), a component of urease, is a micronutrient essential for plant growth and development, but excess Ni is toxic to plants. Tomato (Solanum lycopersicum L.) is one of the important vegetables worldwide. Excessive use of fertilizers and pesticides led to Ni contamination in agricultural soils, thus reducing yield and quality of tomatoes. However, the molecular regulatory mechanisms of Ni toxicity responses in tomato plants have largely not been elucidated. Here, we investigated the molecular mechanisms underlying the Ni toxicity response in tomato plants by physio-biochemical, transcriptomic and molecular regulatory network analyses. Ni toxicity repressed photosynthesis, induced the formation of brush-like lateral roots and interfered with micronutrient accumulation in tomato seedlings. Ni toxicity also induced reactive oxygen species accumulation and oxidative stress responses in plants. Furthermore, Ni toxicity reduced the phytohormone concentrations, including auxin, cytokinin and gibberellic acid, thereby retarding plant growth. Transcriptome analysis revealed that Ni toxicity altered the expression of genes involved in carbon/nitrogen metabolism pathways. Taken together, these results provide a theoretical basis for identifying key genes that could reduce excess Ni accumulation in tomato plants and are helpful for ensuring food safety and sustainable agricultural development.
Impact of ataxia aetiology on self-reported mental health, fatigue, cognition and ataxia symptom severity
Authors: Jenkins Emma , Dunger Warren 
Published: May 2024

Abstract
Introduction
It has been increasingly recognised that the impact of Ataxia extends beyond physical and motor symptomology. However, it is less known whether self-reported non-motor and ataxia symptom severity varies across ataxias of differing aetiology, which would have important implications for providing more targeted treatment.

Aim
This study aimed to investigate the impact of ataxia aetiology (hereditary, acquired or idiopathic) on self-reported depression, anxiety, fatigue, cognitive deficits, and ataxia symptom severity. Comparisons were also made between the ataxia sample as a whole and a neurologically healthy control group.

Method
Responses were collected using a cross-sectional online survey to recruit a national UK sample of people with ataxia.

Results
The study recruited 110 participants with ataxia (hereditary = 51, acquired = 16, idiopathic = 43) and 32 healthy controls. No significant differences were found across study variables for different causes of ataxia. However, participants with ataxia did report significantly higher levels of depression, anxiety, fatigue, cognitive deficits, and ataxia symptom severity compared to healthy controls.

Conclusion
This study found that participants with ataxia self-reported increased non-motor symptoms compared to healthy controls, which was a generally homogenous experience across different causes of ataxia. There was also considerable comorbidity of symptoms which requires further exploration. This study highlights the need for early assessment and intervention to address these non-motor symptoms in ataxia populations.
The Temple of Our Soul
Authors: Anonymous  
Published: May 2024

The Temple of our Soul is one of the most attractive spiritual texts of the late Middle Ages and early modern period. Written by an anonymous woman, who was also the author of influential The Evangelical Pearl, this masterpiece offers insights into the mystical aspects of Christianity that were widespread in Rhineland and the Low Countries. For political, socio-economic, and geographical reasons, spiritual writings from the Low Countries were highly influential in France, England, and Spain. Language barriers, however, have made the original texts inaccessible to many scholars and students. This bilingual edition offers the first English translation The Temple of our Soul together with the original Dutch text. This edition includes an introduction that provides insights into the text's key themes and the social context in which it was written. In addition to students of medieval mysticism, it will also be of interest to scholars of late medieval and early modern vernacular literature and feminist theology.
Human Perfection, Transfiguration and Christian Ethics
Authors: Gill Robin 
Published: May 2024

Most people would agree that human perfection is unattainable. Indeed, theologians have typically expressed ambivalence about the possibility of human perfection. Yet, paradoxically, depictions of human perfection are widespread. In this volume, Robin Gill offers an interdisciplinary study of human perfection in contemporary secular culture. He demonstrates that the language of perfection is present in church memorials, popular depictions of sport, food, music and art, liturgy, and philosophy. He contrasts these examples with the socio-psychological concept of 'maladaptive perfectionism', using commercial cosmetic surgery as an example, as well as the 'adaptive perfectionism' suggested in the lives of Henry Holland, Paul Farmer, and, more ambivalently, Ludwig Wittgenstein. Gill then provides an in-depth analysis of New Testament and Septuagint usage of teleios and theological debates about the human perfection of Jesus. He argues that the Synoptic accounts of the Transfiguration offer a template for a Christian understanding of perfection that has important ecumenical implications within social ethics.
Five steps to high quality antimicrobial stewardship research
Authors: Langford Bradley J. , Bailey Pamela , Livorsi Daniel J. , Brown Kevin A. , Advani Sonali D. , Dodds Ashley Elizabeth , Bearman Gonzalo , Nori Priya 
Published: May 2024

Abstract
The escalating threat of antimicrobial resistance (AMR) necessitates impactful, reproducible, and scalable antimicrobial stewardship strategies. This review addresses the critical need to enhance the quality of antimicrobial stewardship intervention research. We propose five considerations for authors planning and evaluating antimicrobial stewardship initiatives. Antimicrobial stewards should consider the following mnemonic ABCDE: (A) plan Ahead using implementation science; (B) Be clear and thoroughly describe the intervention by using the TidIER checklist; (C) Use a Checklist to comprehensively report study components; (D) Select a study Design carefully; and (E) Assess Effectiveness and implementation by selecting meaningful outcomes. Incorporating these recommendations will help strengthen the evidence base of antimicrobial stewardship literature and support optimal implementation of strategies to mitigate AMR.
POUR-EL’S LANDSCAPE
Authors: KURAHASHI TAISHI , VISSER ALBERT 
Published: May 2024

AbstractWe study the effective versions of several notions related to incompleteness, undecidability, and inseparability along the lines of Pour-El’s insights. Firstly, we strengthen Pour-El’s theorem on the equivalence between effective essential incompleteness and effective inseparability. Secondly, we compare the notions obtained by restricting that of effective essential incompleteness to intensional finite extensions and extensional finite extensions. Finally, we study the combination of effectiveness and hereditariness, and prove an adapted version of Pour-El’s result for this combination.
Comparability and Value in Comic-to-Film Adaptations
Authors: Pratt Henry John 
Published: May 2024

Abstract
In this article, I argue, adverting to critical practices, that film adaptations are comparable with the comics that serve as their sources. The possibility of comparison presumes the existence of covering values according to which these comparisons are made. I raise four groupings of covering values for comics—narrative, pictorial, historical, and referential—and show how they apply to film adaptations as well, and argue that a fifth kind of value, fidelity, is relevant to comparisons of source comics to film adaptations. I close with a discussion of different types of fidelity that might be brought to bear in evaluation.
An ethical leadership assessment center pilot: Assessing and developing moral person and moral manager dimensions
Authors: d’Amato Alexis , Murugavel Vignesh , Medeiros Kelsey , Watts Logan L. 
Published: May 2024

AbstractEthical leaders are those who exemplify moral behavior personally, as well as those who facilitate follower ethical behavior. Although recent attention has been given to the ethical leadership construct, there remains a lack of innovation regarding the assessment and development of ethical leaders in organizations. To address these issues, a pilot study was conducted to examine the convergent validity of an ethical leadership assessment center, as well as the efficacy of using assessment center feedback to foster ethical leadership. Assessees completed a battery of pre tests, a virtual business simulation with a novel exercise, and a set of post tests. Half of the assessees were randomly assigned to a feedback condition, whereas the other half did not receive feedback until after the post tests were completed. Due to low statistical power, quantitative results were inconclusive. Nevertheless, qualitative insights were gained that point to implications for validating assessment center methodologies when assessing and developing ethical leadership.
Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations
Authors: Paul Sarah E. , Baranger David A.A. , Johnson Emma C. , Jackson Joshua J. , Gorelik Aaron J. , Miller Alex P. , Hatoum Alexander S. , Thompson Wesley K. , Strube Michael , Dick Danielle M. , Kamarajan Chella , Kramer John R. , Plawecki Martin H. , Chan Grace , Anokhin Andrey P. , Chorlian David B. , Kinreich Sivan , Meyers Jacquelyn L. , Porjesz Bernice , Edenberg Howard J. , Agrawal Arpana , Bucholz Kathleen K. , Bogdan Ryan 
Published: May 2024

AbstractBackgroundAlthough the link between alcohol involvement and behavioral phenotypes (e.g. impulsivity, negative affect, executive function [EF]) is well-established, the directionality of these associations, specificity to stages of alcohol involvement, and extent of shared genetic liability remain unclear. We estimate longitudinal associations between transitions among alcohol milestones, behavioral phenotypes, and indices of genetic risk.MethodsData came from the Collaborative Study on the Genetics of Alcoholism (n = 3681; ages 11–36). Alcohol transitions (first: drink, intoxication, alcohol use disorder [AUD] symptom, AUD diagnosis), internalizing, and externalizing phenotypes came from the Semi-Structured Assessment for the Genetics of Alcoholism. EF was measured with the Tower of London and Visual Span Tasks. Polygenic scores (PGS) were computed for alcohol-related and behavioral phenotypes. Cox models estimated associations among PGS, behavior, and alcohol milestones.ResultsExternalizing phenotypes (e.g. conduct disorder symptoms) were associated with future initiation and drinking problems (hazard ratio (HR)⩾1.16). Internalizing (e.g. social anxiety) was associated with hazards for progression from first drink to severe AUD (HR⩾1.55). Initiation and AUD were associated with increased hazards for later depressive symptoms and suicidal ideation (HR⩾1.38), and initiation was associated with increased hazards for future conduct symptoms (HR = 1.60). EF was not associated with alcohol transitions. Drinks per week PGS was linked with increased hazards for alcohol transitions (HR⩾1.06). Problematic alcohol use PGS increased hazards for suicidal ideation (HR = 1.20).ConclusionsBehavioral markers of addiction vulnerability precede and follow alcohol transitions, highlighting dynamic, bidirectional relationships between behavior and emerging addiction.
The contribution of cannabis use to the increased psychosis risk among minority ethnic groups in Europe
Authors: Selten J. P. , Di Forti M. , Quattrone D. , Jones P. B. , Jongsma H. E. , Gayer-Anderson C. , Szöke A. , Llorca P. M. , Arango C. , Bernardo M. , Sanjuan J. , Santos J. L. , Arrojo M. , Tarricone I. , Berardi D. , Lasalvia A. , Tosato S. , la Cascia C. , Velthorst E. , van der Ven E. M. A. , de Haan L. , Rutten B. P. , van Os J. , Kirkbride J. B. , Morgan C. M. , Murray R. M. , Termorshuizen F. 
Published: May 2024

AbstractBackgroundWe examined whether cannabis use contributes to the increased risk of psychotic disorder for non-western minorities in Europe.MethodsWe used data from the EU-GEI study (collected at sites in Spain, Italy, France, the United Kingdom, and the Netherlands) on 825 first-episode patients and 1026 controls. We estimated the odds ratio (OR) of psychotic disorder for several groups of migrants compared with the local reference population, without and with adjustment for measures of cannabis use.ResultsThe OR of psychotic disorder for non-western minorities, adjusted for age, sex, and recruitment area, was 1.80 (95% CI 1.39–2.33). Further adjustment of this OR for frequency of cannabis use had a minimal effect: OR = 1.81 (95% CI 1.38–2.37). The same applied to adjustment for frequency of use of high-potency cannabis. Likewise, adjustments of ORs for most sub-groups of non-western countries had a minimal effect. There were two exceptions. For the Black Caribbean group in London, after adjustment for frequency of use of high-potency cannabis the OR decreased from 2.45 (95% CI 1.25–4.79) to 1.61 (95% CI 0.74–3.51). Similarly, the OR for Surinamese and Dutch Antillean individuals in Amsterdam decreased after adjustment for daily use: from 2.57 (95% CI 1.07–6.15) to 1.67 (95% CI 0.62–4.53).ConclusionsThe contribution of cannabis use to the excess risk of psychotic disorder for non-western minorities was small. However, some evidence of an effect was found for people of Black Caribbean heritage in London and for those of Surinamese and Dutch Antillean heritage in Amsterdam.
The impact of health impairments on employment entry and the quality of employment among basic income support recipients in Germany
Authors: Zabel Cordula 
Published: May 2024

Abstract
Policies for recipients of basic income support for jobseekers in Germany focus on activation and quick labour market integration. Yet, the majority of benefit recipients report severe health impairments. Against this background, the article investigates implications of health impairments for benefit recipients’ jobcentre relationship and employment opportunities. The analyses show that 63 per cent of non-employed benefit recipients report health restrictions on their employment capabilities, 51 per cent report severe health impairments, and 25 per cent that they cannot work at all. The most frequent types of health impairments are musculoskeletal and mental health impairments. Health impairments significantly reduce entry rates into socially insured employment, but do not seem to inhibit taking up uninsured minijobs. Counselling frequency increases job entry rates for benefit recipients without health impairments in the short-term. For those with health impairments, no short-term effects are found over a one-year follow-up period. Policy responses could include a more explicit acknowledgement of health impairments as a central issue for benefit recipients. Greater investments in rehabilitation and subsidised employment could be part of a strategy to improve opportunities for benefit recipients with health impairments to find better-quality (part-time) employment instead of uninsured minijobs. The analyses are based on linked longitudinal PASS survey and administrative data.
Does checking-in help? Understanding L2 learners’ autonomous check-in behavior in an English-language MOOC through learning analytics
Authors: Zhang Yining , Yang Fang , Yang Haolin , Han Shuyuan 
Published: May 2024

AbstractConcerns over the quality of teaching in massive open online courses devoted to language learning (LMOOCs) have prompted extensive research on learning behavior in such courses. The purpose of this study is to gain a better understanding of autonomous learning check-ins – that is, individuals sharing their own learning records and/or other information about their learning-related experience – a novel behavior that has not been studied in previous LMOOC research. Using learning analytics, we found that just 6.2% (n = 699) of a sample of 11,293 learners autonomously engaged in check-in behavior, and that the content of these learners’ check-ins varied considerably according to their contexts and the language skills they were seeking to acquire. We further found (1) a positive association between check-in behavior and LMOOC completion; (2) that students who chose to check in earned relatively low grades on unit quizzes, especially in their early stage of learning, but outperformed the non-check-in group significantly in final exam scores; and (3) that those who checked in engaged with a significantly wider array of in-LMOOC learning components than those who did not, and thus accessed a wider system of language-learning experiences. Taken together, these results confirm that check-in behavior can aid the process of learning in an LMOOC and further highlight this behavior’s wider potential to aid self-directed autonomous online learning.
Assessment of normal tissue objectives in RapidArc treatment for cervical cancer
Authors: P. Athulya , Manna Sumanta , Singh Sharad 
Published: May 2024

Abstract

Purpose:
The normal tissue objective (NTO) is a tool used in inverse-planned intensity-modulated radiation therapy (IMRT) to minimize dose dispersion to surrounding tissues. The current study focuses on the NTO’s impact on RapidArc treatment plans for cervical cancer patients or its role in reducing doses to healthy surrounding tissues.

Material and methods:
This study included 11 cervical cancer patients who underwent RapidArc treatment. We assessed plans both with and without the NTO objective by evaluating parameters such as homogeneity, conformity, gradient index (GI), IMRT factor, integral dose and the volume of normal tissues receiving low doses of 40, 30, 20 and 10 Gy. Further, differences between automatic NTO and manual NTO were evaluated using Wilcoxon signed-rank test.

Results:
There were no significant differences in the conformity index, homogeneity index, IMRT factor and integral dose between plans with automatic NTO and those with manual NTO RapidArc plans. However, we did observe a clear advantage in using manual NTO for controlling low-dose exposure to normal tissues. The comparisons between automatic and manual NTO resulted in a GI of 3·1 ± 0·3 versus 2·7 ± 0·68 (p = 0·008). Furthermore, we noticed a significant reduction in the volumes receiving low doses (V10, V20, V30 and V40) with the manual NTO settings.

Conclusion:
The NTO plays a crucial role in optimizing RapidArc plans for treating cervical cancer. Based on the findings of this study, manual NTO settings of distance from PTV border xstart = 0·5 mm, start dose f0 = 105%, end dose f∞ = an average of 40%, dose fall-off 0·2 mm–1 were optimal. Further research involving a larger sample size and exploration of various NTO parameters is necessary to validate our results.
Conceptualizing National Advisory Boards in primary care research: application to the Two in One HIV and COVID screening and testing model
Authors: Ward Maranda C. , Delgado Setien Paloma , Konopasky Abigail , Conserve Donaldson F. 
Published: May 2024

Abstract
The authors report on their development of a National Advisory Board (NAB) to guide a funded project: Two in One: HIV + COVID-19 Screening and Testing Model. This project aimed to improve primary care practitioners’ capacity to routinize HIV, PrEP/PEP, and COVID-19 vaccine screenings for all their patients while relying on culturally responsive communication with their minoritized patients. To approach their monumental research and education tasks, they created a NAB, drawing from the literature on advisory boards to (a) promote board member engagement and (b) progress successfully through the six stages suggested for successful advisory boards. A midpoint survey and final focus groups with NAB members indicated mixed levels of engagement, a sense of time and work being valued, and pride in the media and academic reach of the project. The authors offer considerations for others considering forming a NAB to guide primary care research and interventions.