bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology
Authors: Alsina Raquel , Riba Marta , Pérez-Millan Agnès , Borrego-Écija Sergi , Aldecoa Iban , Romera Clara , Balasa Mircea , Antonell Anna , Lladó Albert , Compta Yaroslau , del Valle Jaume , Sánchez-Valle Raquel , Pelegrí Carme , Molina-Porcel Laura , Vilaplana Jordi 
Published: June 2024

AbstractWasteosomes (or corpora amylacea) are polyglucosan bodies that appear in the human brain with aging and in some neurodegenerative diseases, and have been suggested to have a potential role in a nervous system cleaning mechanism. Despite previous studies in several neurodegenerative disorders, their status in frontotemporal lobar degeneration (FTLD) remains unexplored. Our study aims to characterize wasteosomes in the three primary FTLD proteinopathies, assessing frequency, distribution, protein detection, and association with aging or disease duration. Wasteosome scores were obtained in various brain regions from 124 post-mortem diagnosed sporadic FTLD patients, including 75 participants with tau (FTLD-tau), 42 with TAR DNA-binding protein 43 (FTLD-TDP), and 7 with Fused in Sarcoma (FTLD-FUS) proteinopathies, along with 29 control subjects. The wasteosome amount in each brain region for the different FLTD patients was assessed with a permutation test with age at death and sex as covariables, and multiple regressions explored associations with age at death and disease duration. Double immunofluorescence studies examined altered proteins linked to FTLD in wasteosomes. FTLD patients showed a higher accumulation of wasteosomes than control subjects, especially those with FTLD-FUS. Unlike FTLD-TDP and control subjects, wasteosome accumulation did not increase with age in FTLD-tau and FTLD-FUS. Cases with shorter disease duration in FTLD-tau and FTLD-FUS seemed to exhibit higher wasteosome quantities, whereas FTLD-TDP appeared to show an increase with disease progression. Immunofluorescence studies revealed the presence of tau and phosphorylated-TDP-43 in the periphery of isolated wasteosomes in some patients with FTLD-tau and FTLD-TDP, respectively. Central inclusions of FUS were observed in a higher number of wasteosomes in FTLD-FUS patients. These findings suggest a role of wasteosomes in FTLD, especially in the more aggressive forms of FLTD-FUS. Detecting these proteins, particularly FUS, in wasteosomes from cerebrospinal fluid could be a potential biomarker for FTLD.
Conducting a diabetes mellitus prevention trial in women with GDM in Pakistan: a feasibility study
Authors: Iqbal Romaina , Naz Sabahat , Sheikh Sana , Qureshi Rahat , Bhutta Shereen , Yasmeen Haleema , Azam Iqbal , Gill Paramjit 
Published: June 2024

Abstract
Background
Women with gestational diabetes mellitus (GDM) are at a greater risk of developing type 2 diabetes mellitus (T2DM) than women without GDM. Despite this elevated risk, few trials on the prevention of T2DM among South Asian women with GDM have been reported. Therefore, this study aimed to assess the feasibility of conducting a diabetes prevention program on women with a history of GDM to inform the development of a contextually relevant definitive trial.

Methods
Using a randomized controlled trial, women with GDM (n = 180) who delivered at the study hospitals (one public and one private teaching hospital, Karachi) with fasting blood glucose levels < 120 mg/dl at 6 weeks postpartum were randomized to the intervention (n = 88) or control arms (n = 92). Women in the intervention group received individualized home-based educational sessions from trained community health workers at 0, 1, 3, 6, and 9 months. In addition, they received short text messages, prerecorded messages, and printed educational material (calendars and pamphlets) for reinforcement. The intervention was centered on equipping women with knowledge, skills, and confidence to eat a healthy diet rich in fruits, vegetables, and low-fat dairy products and perform regular physical activity based on walking and household chores to reduce weight (up to 5% of their initial body weight). Women in the control arm received standard care. The feasibility outcomes of the study included screening, recruitment, and retention rates and in-depth interviews at 6 months post-intervention to explore women’s experiences with the intervention. Descriptive analysis and thematic analysis were performed.

Results
Of the 324 women screened during the antenatal care visits and after delivery, 255 (78.7%) were contactable 6 weeks postpartum, and 180 (70.6%) were eligible and randomized to intervention (n = 88) and control (n = 92) groups. Loss to follow-up in the intervention and control arms was 22.7% (n = 20/88) and 18.5% (n = 17/92), respectively. Women expressed satisfaction with home-based counseling and follow-up visits, text message reminders, and printed material in the form of a calendar through our qualitative interviews.

Conclusions
Home-based lifestyle modification intervention augmented with text messages and printed material is feasible. However, to evaluate the intervention’s effectiveness, a larger trial is warranted to assess its long-term impact on diabetes prevention.

Trial registration
ISRCTN, ISRCTN11387113. Registered 5 December 2017—retrospectively registered.
Collaborative listening using multimedia through metacognitive instruction: a case study with less-skilled and more-skilled EFL learners
Authors: Shamsi Esmat , Bozorgian Hossein 
Published: June 2024

AbstractMultimedia is vastly used as authentic and available input in second and foreign-language contexts. To deal with the difficulties and complexities of comprehending these authentic materials, collaborative learning through metacognitive instruction helps develop learners' listening comprehension. The present study has mainly explored the role of using multimedia input through metacognitive instruction of a group of 20 upper-intermediate EFL learners divided into five groups (each including two less-skilled and two more-skilled learners). They received eight weeks of metacognitive instruction in listening at an English language learning institute. Evidence gathered from observation, learners' logs, and semi-structured interviews shows that collaboration, interaction, and the use of metacognitive strategies help learners improve overall listening comprehension. Moreover, the learners had positive attitudes towards utilizing multimedia input, which provided them with some kinesics and prosodic hints to understand the listening content. The findings and pedagogical implications for language learners and teachers are discussed further.
Unveiling the lockdown effects: exploring behavior, dietary habits and weight changes in rural Egypt during COVID-19 lockdown: a cross-sectional retrospective study
Authors: Saleh Mahmoud Reda , Abdelgaied Mohamed Y. , Galal Naira , Tarek Mai , Fouda Aya , Abdelkawy Khaled 
Published: June 2024

Abstract
Background
The COVID-19 lockdown significantly impacted dietary habits and body weights globally, particularly in Egypt, where 57.03% of the population resides in rural areas, despite lack of information. The study examines the impact of COVID-19 lockdown on the weight changes of the rural Egyptian population through behavioral, physical, and dietary changes.

Methods
A cross-sectional online survey using Microsoft Forms was distributed in Delta regions in Egypt. The questionnaire used a modified version of the validated 14- items PREDIMED MedDiet Adherence Screener (MEDAS). The first part of the questionnaire addressed sociodemographic variables whereas the second one included questions related to dietary, behavioral and weight changes of participants. These changes were statistically tested for significance in relation to BMI, gender, home living, current job and family history of obesity.

Results
A total of 306 participated in the study (70% females, 13% obese, 95% living with family, 56% university students, and 36% with family history of obesity). Obese showed a significant increase in sweet intake whereas underweight and normal weight people displayed a significant decrease in eating desire. Both females and males showed significant increase in consumption of fruits and vegetables with significant decrease in soft drink. However, women showed a significant decrease in sport activity relative to men. Participants living with family showed an increase in sweet intake while those living alone explored an increase in meal frequency. Employers revealed a significant decrease in sport activities and people with family history of obesity reported more sleeping times than those without family history of obesity.

Conclusion
During Covid-19 quarantine, Egyptians’ eating habits improved, but daily routines were disrupted. Raising awareness about obesity and providing guidance on maintaining activity, energy, and mood is crucial for future quarantine situations.
Entrepreneurs' competency, marketing innovation, and enterprise growth: uncovering the mediating role of marketing innovation
Authors: Esubalew Amare Abawa , Adebisi Sunday Abayomi 
Published: June 2024

AbstractDespite their large numbers, the vertical growth of micro, small, and medium enterprises (MSMEs) is not readily apparent, even though they have a substantial impact on Ethiopia’s economy. Earlier studies have underscored enterprise-related factors as hindrances to the expansion of MSMEs. However, entrepreneurs are blamed for their limited practice of innovative marketing that the researchers wanted to verify whether marketing innovation can positively influence the growth of MSMEs in Ethiopia. Therefore, the major objective of the study was to examine the effect of competency and marketing innovation on the growth of MSMEs in the Ethiopian business environment taking marketing innovation as a mediating variable. To collect data, researchers used a stratified random sampling technique and obtained data from 288 owner–managers of micro, small, and medium enterprises. The results of the study revealed that competency has a significant direct effect on enterprise growth. However, the study also found that the effect of competency on innovation and the effect of innovation on enterprise growth were not statistically significant. These findings suggest that competency directly influences the growth of enterprises, while the impact of innovation on growth is not evident in the context of Ethiopian enterprises. The negligible impact of competency on marketing innovation, coupled with the minimal effect of marketing innovation itself, suggests that entrepreneurs may not be prioritizing the adoption of innovative marketing strategies, assuming they can sell their existing products. However, such an approach is typically short-sighted and could leave the business exposed to future vulnerabilities. This study adds to the body of knowledge by indicating that marketing innovation does not mediate between competency and the growth of MSMEs. Instead, it is the competency of entrepreneurs that has a direct and exclusive impact on growth.
Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin When Maintained on a High-Fat Diet
Authors: Powell David R , Doree Deon D , Shadoan Melanie K , Platt Kenneth A , Brommage Robert , Vogel Peter , Revelli Jean-Pierre 
Published: June 2024

Abstract
Genes regulating body fat are shared with high fidelity by mice and humans, indicating that mouse knockout (KO) phenotyping might identify valuable antiobesity drug targets. Male Mrs2 magnesium transporter (Mrs2) KO mice were recently reported as thin when fed a high-fat diet (HFD). They also exhibited increased energy expenditure (EE)/body weight and had beiged adipocytes that, along with isolated hepatocytes, demonstrated increased oxygen consumption, suggesting that increased EE drove the thin phenotype. Here we provide our data on these and additional assays in Mrs2 KO mice. We generated Mrs2 KO mice by homologous recombination. HFD-fed male and female Mrs2 KO mice had significantly less body fat, measured by quantitative magnetic resonance, than wild-type (WT) littermates. HFD-fed Mrs2 KO mice did not demonstrate increased EE by indirect calorimetry and could not maintain body temperature at 4 °C, consistent with their decreased brown adipose tissue stores but despite increased beige white adipose tissue. Instead, when provided a choice between HFD and low-fat diet (LFD), Mrs2 KO mice showed a significant 15% decrease in total energy intake resulting from significantly lower HFD intake that offset numerically increased LFD intake. Food restriction studies performed using WT mice suggested that this decrease in energy intake could explain the loss of body fat. Oral glucose tolerance test studies revealed significantly improved insulin sensitivity in Mrs2 KO mice. We conclude that HFD-fed Mrs2 KO mice are thin with improved insulin sensitivity, and that this favorable metabolic phenotype is driven by hypophagia. Further evaluation is warranted to determine the suitability of MRS2 as a drug target for antiobesity therapeutics.
Study on the clinical efficacy, safety and compliance of quality nursing intervention in the treatment of chronic heart failure combined with respiratory tract infections
Authors: Jia Yinan , Li Na , Zhang Xinxin , Lu Zhiwei , You Xiaonan , Xu Qiaoling 
Published: June 2024

Objective: To evaluate the clinical efficacy, safety and compliance of quality nursing intervention in the treatment of chronic heart failure combined with respiratory tract infections.
Methods: This was a retrospective study. One hundred and twenty patients with chronic heart failure combined with respiratory tract infections were recruited at Baoding No.1 Central Hospital from June 2021 to March 2023 and randomly divided into the control group (n=60) and the experimental group (n=60). Patients in the control group were given regular specialist care on the basis of basic treatment, while those in the experimental group were given a quality care intervention model. The differences in clinical efficacy, improvement time of symptoms after treatment, etc. between the two groups were compared and analyzed.
Results: The response rate of the experimental group was 88%, which was significantly higher than that of the control group (73%), with a statistically significant difference (P=0.04). The time of fever reduction, cough subsidence and lung rales disappearance in the experimental group were significantly shorter than those of the control group, with statistically significant differences (P<0.05). The incidence of nursing related adverse events in the experimental group was 8%, which was lower than that of 23% in the control group, with a statistically significant difference(P=0.03).
Conclusion: Quality nursing intervention is an effective treatment for patients with chronic heart failure combined with respiratory infections, boasting a variety of benefits such as reduced nursing risk, improved quality of nursing, and increased patient compliance and satisfaction. It contributes to rapid symptom improvement and significant clinical efficacy.
doi: https://doi.org/10.12669/pjms.40.7.7873
How to cite this: Jia Y, Li N, Zhang X, Lu Z, You X, Xu Q. Study on the clinical efficacy, safety and compliance of quality nursing intervention in the treatment of chronic heart failure combined with respiratory tract infections. Pak J Med Sci. 2024;40(7):---------. doi: https://doi.org/10.12669/pjms.40.7.7873
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Čustveno soočanje s posledicami življenjsko ogrožajočih zdravstvenih stanj
Authors: Simonič Barbara , Pate Tanja 
Published: June 2024

Uvod: Doživetje in preživetje akutnega življenjsko ogrožajočega zdravstvenega stanja je visoko stresen(travmatičen) dogodek, ki pomembno vpliva na življenje posameznika in njegovih svojcev, zato je bil namenobravnavane raziskave preučiti povezavo izkušnje tovrstnega dogodka s čustvenim doživljanjem.Metode: Opravljeni sta bili deskriptivna in korelacijska presečna raziskava na udeležencih z izkušnjo akutnega življenjsko ogrožajočega zdravstvenega stanja (n = 54) in svojcih(n = 59).Rezultati: Ozaveščanje čustev kot način soočanja z življenjsko ogrožajočimi stanji je pozitivno povezano z življenjsko uspešnostjo (r = 0,455, p < 0,01), posttravmatsko rastjo (r = 0,341, p < 0,01) in doživljanjem individualnih moči (r = 0,337, p < 0,01). Izražanje čustev kot način soočanja je pozitivno povezano z življenjsko uspešnostjo (r = 0,416, p < 0,01), posttravmatsko rastjo (r = 0,252, p < 0,05) in doživljanjem individualnih moči (r = 0,481, p < 0,01). Spoprijemanje s čustvi pri pacientih pojasnjuje spol (β = –0,51), pri svojcih pa posttravmatska rast (β = 0,41) in individualne moči (β = 0,51).Diskusija in zaključek: Čustveno spoprijemanje ob soočanju s posledicami življenjsko ogrožajočega akutnega zdravstvenega stanja ima pomembno vlogo pri posttravmatski rasti, večjem občutku življenjske uspešnosti in individualnih moči. Ustrezno čustveno soočanje s stresom ob doživetju in preživetju življenjsko ogrožajočega zdravstvenega stanja je ključnega pomena pri uspešni prilagoditvi na življenje po tem dogodku.
Spolna zdravstvena pismenost slovenskih srednješolcev
Authors: Šporin Marta , Kamenšek Tina , Milavec Kapun Marija 
Published: June 2024

Uvod: Spolna vzgoja mladostnikov je v šolah pomembno področje izobraževanja. Namen raziskave je bil oceniti znanje o spolnosti, izkušnje, vedenje in vire informacij o spolnosti med slovenskimi dijaki.Metode: Uporabljen je bil spletni vprašalnik, poslan na vse srednje šole v osrednjeslovenski regiji, s povabilom dijakom prvih letnikov. V analizo so bili vključeni odgovori 201 anketiranca. Sodelujoči so bili v povprečju stari 15,59 let, 57 % ženskega spola in 67 % jih je bilo gimnazijcev. Podatki so bili statistično analizirani s testi hi-kvadrat, Mann-Whitneyjevim U-testom in t-testom.Rezultati: Najpogostejši viri informacij o spolnosti za dijake so splet (67,0 %) in prijatelji (60,4 %). Večina dijakov želi informacije pridobiti od zdravstvenih delavcev (61,2 %) in najmanj od učiteljev (26,5 %). Spolna izkušnja z vaginalno penetracijo je pri dijakih/-njah srednjih in poklicnih srednjih šol pogostejša v primerjavi z gimnazijci/-kami (χ2 = 7,863, p = 0,005). Znanje o spolnosti se razlikuje glede na spol (U = 2257,500, p = 0,003) in vrsto srednješolskega izobraževanja (U = 1943,500, p = 0,001). Znanje o spolnosti je pozitivno povezano s količino pogovora o različnih temah o spolnosti, razen o božanju. Ni pa povezano s spolno aktivnostjo in uporabo zaščite.Diskusija in zaključek: Pomembno je, da se več pozornosti nameni spolni vzgoji srednješolcev. Medicinske sestre v šolskem okolju lahko spodbujajo medvrstniško informiranje, opolnomočajo starše za pogovor z mladostniki in izvajajo spolno vzgojo. Rezultati raziskav o učinkovitosti različnih oblik in vsebin spolne vzgoje so lahko osnova za nadgradnjo preventivnih programov
PENGEMBANGAN UMKM KONVEKSI ALVARO PRODUCTION MELALUI BRANDING DAN TEKNOLOGI DIGITAL DI DESA REMBUN PEKALONGAN
Authors: Falah Fajrul , Tiani Riris , Marwini Marwini , Sekar Dyah Ayu , Iriani Rossi Nur , Nada Elysa Qothrun 
Published: June 2024

ABSTRAKSalah satu usaha UMKM yang sedang mengalami pertumbuhan dan memiliki potensi yang menjanjikan di Desa Rembun adalah Alvaro Production. UMKM di Desa Rembun Kabupaten Pekalongan ini, menjadi mitra dalam program pengabdian kepada Masyarakat. Tujuan pengabdian kepada masayrakat ini adalah pengembangan UMKM Alvaro Production melalui branding dan pemanfaatan teknologi digital. Metode dan tahapan yang dilakukan dalam pelaksanaan pengabdian ini meliputi, studi literature, survei, observasi, wawancara mendalam, pelatihan dan pemebrian materi, dan praktik. Luaran yang dihasilkan dalam kegiatan ini antara lain pembuatan logo produk, pemanfaatan media sosial, pembuatan website Linktree, pembuatan katalog produk, dan penambahan lokasi UMKM pada Google Maps. Hasil pelaksanaan pengabdian memuat strategi branding meningkatkan kesadaran merek, aksesibilitas produk, dan interaksi pelanggan. Selain itu, mitra memiliki akses pemasaran yang lebih meluas. kegiatan ini perlu ditindaklanjuti dengan perspektif atau pendekatan lain, sehingga mitra Alvaro Production lebih berkembang dan Desa rembun memiliki produk unggulan.Kata Kunci: Pengembangan, Branding, Teknologi Digital, UMKM, Rembun ABSTRACTOne of the MSME businesses that is experiencing growth and has promising potential in Rembun Village is Alvaro Production. MSMEs in Rembun Village, Pekalongan Regency, are partners in the community service program. The aim of this community service is the development of Alvaro Production MSMEs through branding and the use of digital technology. The methods and stages carried out in implementing this service include literature studies, surveys, observations, in-depth interviews, training and providing materials, and practice. The outputs produced in this activity include creating product logos, utilizing social media, creating a Linktree website, creating product catalogues, and adding MSME locations to Google Maps. The results of the implementation of the service include branding strategies to increase brand awareness, product accessibility and customer interaction. In addition, partners have wider marketing access. This activity needs to be followed up with another perspective or approach, so that Alvaro Production partners develop further and Rembun Village has superior products.Keywords: Development, Branding, Digital Technology, UMKM, Rembun
EDUKASI ANTI-BULLYING MELALUI PEMBUATAN PRODUK KEMAS ULANG INFORMASI BUKU CERITA MEWARNAI DI SD KEBON DALEM 2 SEMARANG
Authors: Christiani Lydia , Alfharezi M. Salman , Kuntardi Dani Marcelo Septiano 
Published: June 2024

ABSTRAKDi Indonesia, kasus bullying atau perundungan semakin meningkat seiring berlalunya waktu, tersebar di berbagai wilayah, dan mulai menjadi persoalan sosial yang semakin serius, terutama dalam konteks pendidikan. Salah satu contoh kasus bullying terjadi di SD Kebon Dalem 2 Semarang, di mana tercatat beberapa insiden perselisihan dan pembentukan kelompok antar siswa yang menghasilkan konflik pertemanan dalam bentuk perundungan. Tujuan dari kegiatan pengabdian masyarakat ini adalah memberikan pemahaman tentang bullying atau perundungan dengan harapan dapat menjadi langkah preventif terhadap kasus perundungan. Kegiatan ini dilaksanakan melalui penggunaan produk kemas ulang informasi buku cerita mewarnai berjudul “Bunga Persahabatan” sebagai sarana edukasi yang menarik bagi para siswa, sehingga pesan tentang pentingnya persahabatan dan etika berteman memberikan manfaat dalam pengembangan keterampilan anak-anak dan pemahaman moral dapat tersampaikan dengan baik. Dengan demikian, produk ini memiliki potensi sebagai alat efektif dalam usaha pencegahan bullying di lingkungan sekolah dasar.Kata kunci: bullying, pendidikan, perundungan, pengabdian masyarakat, sekolah dasar ABSTRACTIn Indonesia, cases of bullying are increasingly prevalent over time, spreading across various regions, and emerging as a progressively serious social issue, particularly within the realm of education. One example of bullying occurred at SD Kebon Dalem 2 Semarang, where several incidents of disputes and the formation of student groups resulted in friendship conflicts in the form of bullying. The objective of this community service activity is to provide an understanding of bullying with the hope of serving as a preventive measure against bullying cases. This activity is carried out through the use of information repackaging products entitled coloring story books titled "Bunga Persahabatan" as an engaging educational tool for students, allowing the message about the importance of friendship and ethical behavior to benefit the development of children's skills and moral understanding. Thus, this product has the potential to be an effective tool in the effort to prevent bullying in elementary school environments.Keywords: bullying, education, friendship conflicts, indonesia, preventive measure