bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is pain a main influence for various spiritual needs of patients with terminal cancer?: a multicenter cross-sectional study in southern China
Authors: Wu Zilan , Zhu Fang , Luo Huiyu , Zhu Hongyu , Zhang Yu , Lin Jinyuan , Yang Ling , Ke Xi 
Published: May 2024

Abstract

Background: Different degrees of spiritual needs are prevalent in terminal patients, but limited information on the influencing factors of different types of spiritual needs. The effect of pain on spiritual needs is still controversial. The purposes of this study are to investigate the spiritual needs of patients with terminal cancer and analyze their influencing factors, understand the relationship between pain and different types of spiritual needs, and provide a reference for improving the hospice care model of terminal cancer patients in the eastern cultural background.
Methods: This study was designed in reference to the STROBE guidelines. Participants were recruited from 4 centers in southern China using convenience sampling (N=224). A cross-sectional study was used to investigate the socio-demographic, clinical case data and spiritual needs of terminal patients. Univariate and multivariate tests were performed in various statistical methods.
Results: The spiritual needs of patients with terminal cancer was 71.69 ±19.63. Multiple linear regression analysis showed that religion, place of residence, medical payment method, pain properties and number of pain sites predicted 33.7% of the overall spiritual needs of patients with terminal cancer. Different types of spiritual needs are influenced by different factors.
Conclusion: The influence factors of different types of spiritual needs vary, so the spiritual care of patients with terminal cancer needs to give personalized spiritual care according to the content and degree of patients' needs. Nursing staff should pay more attention to the spiritual needs of love and connection, hope and peace of patients with more severe pain level.
Feasibility Study of Multi Laue Lens Based SPECT with a Dedicated 3D Reconstruction Algorithm: A First Monte Carlo Study
Authors: Barhoum Alaa , Tahtali Murat , Guatelli Susanna , Camattari Riccardo , Miroshnichenko Andrey 
Published: May 2024

Abstract

The development of in-vivo imaging techniques has significantly advanced biomedical science and cancer diagnosis, yet their limited spatial resolution constrains their utility in small-animal studies and early-stage tumor detection. This study introduces a novel SPECT system employing X-ray and gamma-ray focusing optics—traditionally used in astronomy—to enhance spatial resolution in small object imaging at sub-millimeter scales without compromising sensitivity. Our innovative design utilizes an array of Laue lenses, eliminating the need for traditional collimators such as parallel or pinhole collimators, thereby achieving ultra-high spatial resolution. A custom Monte Carlo simulation models the system's spatial resolution and sensitivity, supported by a tailored 3D reconstruction algorithm that complements the system’s geometry. Findings reveal that our proposed system can achieve a spatial resolution of 0.1 mm full width at half maximum (FWHM) and a sensitivity of 1,670 cps/µCi. This setup allows the discrimination of adjacent volumes as small as 0.113 nL, far surpassing the capabilities of existing SPECT systems, including the SIEMENS parallel LEHR and multi-pinhole (5-MWB-1.0) Inveon SPECT, which are limited to a 2 mm resolution due to inherent resolution-sensitivity trade-offs. The proposed design could revolutionize SPECT imaging, significantly impacting transgenic animal research and early-stage tumor detection with its sub-millimeter resolution.
Recovering from cardiac action potential pathologies: a dynamic view
Authors: Morelo Patrick A. , Girardi-Schappo Mauricio , Paulino Bianca L. , Marin Bóris , Tragtenberg Marcelo H. R. 
Published: May 2024

Abstract

Many human cells fire plateau action potentials,
from the endocrine system to the heart. For example, cardiac myocites may
present perturbations of the
plateau that are linked to the long QT syndrome and cardiac arrhythmia.
Here, we provide a unified and minimalist dynamic explanation
for some of the known
forms of the loss of stability of the plateau, which are linked to these
pathologies. One of these forms is a newly found non-chaotic aperiodic
oscillation mode of autonomous plateau spikes. This happens via an infinite period bifurcation of the
interspike interval.
We accomplish this through a simple map model of the action potential containing two fast and one slow variables.
This reveals a small set of ingredients for the
observation of plateau anomalies,
and allows us to propose different
ways to recover from them
by adjusting slow-fast timescales and the fast-fast coupling conductance.
This integrated and generic view might provide insights for complex models with many variables and parameters.
One of the predictions of the model is the existence of a critical value in the fast-fast coupling conductance below which cardiac spike anomalies completely disappear, regardless of other currents.
Notwithstanding, excitable cardiac spikes stay away from prolongation if their slow variable time scales ratio between drive and recovery is less than one.
These findings might help the future development of innovative treatments for the related diseases.
Infrared and visible video fusion method based on local differential correlation features and PID control
Authors: Tang Xiaolin , Wang Jun 
Published: May 2024

Abstract

The purpose of infrared and visible video fusion is to combine the complementary features of videos from different modalities. Most fusion algorithms ignore the feature associations of adjacent frames and the guidance of the source frames to the fusion process. Therefore, this paper proposes a new fusion method. First, a spatial-domain multi-attribute detail feature extraction model is proposed, which is capable of extracting the base layer, the bright detail layer and the dark detail layer of the source frames separately. Then, we propose an associated feature extraction model for adjacent frames, which improves the spatial continuity of the fused video. Furthermore, an exponential homomorphic filter is proposed, which simultaneously increases the dynamic range and contrast of the source infrared frames to obtain a general salient target extraction model. In the feature fusion stage, a weighted fusion rule based on edge intensity is used in the detail layer. Then we design the controller, transfer function and measurement function separately, so as to construct a closed-loop proportional-integral-derivative (PID) control system to fuse the base layer, which ensures that the fused video maintains more information of the source video. Experiments on public datasets demonstrate that our fusion method outperforms some state-of-the-art algorithms.
High-Performance Hydrogen Sulfide Gas Sensors Based on Conjugated Polymer Nanocomposites
Authors: Rashmi H S , Vishnumurthy K A , Kusanur Raviraj 
Published: May 2024

Abstract

In this study, we present the synthesis of a conjugated polymer through the oxidative polymerization method and the fabrication of nanocomposite thin-film sensors tailored for the detection of hydrogen sulfide (H2S) gas. Nanocomposite sensors have exhibited outstanding sensitivity, especially in response to 5 ppm of H2S gas. These sensors consistently demonstrated remarkable selectivity for the target gas at a 5 ppm concentration compared to other tested gases. Notably, the response time for these sensors was rapid, with values consistently ≤ 1 second, and the recovery times were notably shorter than those of pure polymer sensors. The highest sensitivity, reaching 1.22, was achieved by the 15% conjugated polymer nanocomposite (PCF) sensor, showcasing exceptional response-recovery characteristics. Furthermore, we calculated the limit of detection for the pure polymer and PCF nanocomposite sensors to be 9.8 ppm and 5.1 ppm, respectively. Our sensors also exhibited excellent repeatability, with consistent performance over 5 cycles when exposed to 2.5 ppm of gas at room temperature. This enhanced response-recovery behavior can be attributed to an increased number of active sites on the sensor's surface, resulting in faster gas adsorption and desorption processes. Consequently, these findings hold promise for the development of highly efficient hydrogen sulfide gas sensors.
Exploring Stress-Induced Mechanisms in Acne Pathogenesis
Authors: Siddiqui Ifrah , Rais Ubaid , Tahir Mehak 
Published: May 2024

Abstract

Background: Acne vulgaris affects millions worldwide, with psychological stress emerging as a significant contributor to its development. Stress influences acne via hormonal fluctuations, inflammation, immune modulation, altered skin barrier function, and lifestyle changes. Understanding these mechanisms is crucial for developing effective management strategies. This study aims to elucidate the role of stress in acne pathogenesis to inform more targeted interventions.Methods: A comprehensive search encompassing databases such as PubMed, MEDLINE, Google Scholar, open access / subscription-based journals, was conducted to retrieve relevant articles for the investigation of key mechanisms through which stress impacts acne development and exacerbation. Articles were searched without any date restrictions. Utilizing the criteria delineated in the methodology section, studies were systematically reviewed to elucidate the relationship between psychological stress and acne development and exacerbation. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).Results: Our investigation revealed multiple key mechanisms through which stress impacts acne development and exacerbation. Hormonal fluctuations, including increases in cortisol and androgens, stimulate sebaceous gland activity, leading to excess sebum production. Inflammation, triggered by stress-induced cytokine release, exacerbates acne lesions. Stress also impairs skin barrier function, alters immune responses, and influences lifestyle factors such as diet, sleep, and skincare habits, all of which contribute to acne severity. Additionally, neuropeptides, oxidative stress, insulin resistance, altered skin pH, vascular changes, and changes in the skin microbiome play significant roles in stress-induced acne pathogenesis. These findings highlight the varied nature of stress-acne interactions and underscore the importance of addressing both physiological and psychological factors in acne management strategies.Conclusion: Our investigation reveals stress's varied impact on acne through hormonal fluctuations, inflammation, barrier function impairment, immune modulation, behavioral factors, psychological distress, neuropeptides, oxidative stress, insulin resistance, altered skin pH, vascular changes, lifestyle habits, and skin microbiome alterations. Addressing these mechanisms underscores the need for holistic acne management strategies integrating stress reduction techniques with conventional treatments. Understanding stress-acne interplay emphasizes the importance of comprehensive approaches to improve acne outcomes, recognizing the bidirectional relationship between physiological and psychological factors in acne pathogenesis and exacerbation.
Assessment of Three Fast Growing Populus Deltoides Species in Various Soil Profiles Under Nursery Conditions
Authors: Saleem Aamir , Jamshed Zeeshan , Farooq Mohammad Umar , Khan Nosheen , Anwar Fawad 
Published: May 2024

Abstract

Populus plants arefast-growing plants that exhibit strong adaptability and a short rotation period. Poplar enhanced the carbon stock, which ultimately helps in combating climate change and sustaining livelihoods. Pakistan has a shortage of firewood and timber. Thus, hybrid fast-growing plants are the only way to balance wood demand and supply in the country. Therefore, the objective of the present study was to evaluate and compare the growth patterns and carbon stocks of three Populus deltoides varieties in three soil media under nursery conditions. To achieve the study goals, three fast-growing hybrid species of Populus deltoides, Italian Populus (euramerciana), clone A-Y48, and local Populus were used. Three healthy plants of mothers aged one to two years were selected from the field area of the Rangeland Research Institute (RRI), NARC. The cuttings were planted in 90 pots after being filled with three different media, and plant growth was recorded after seven days for the number of leaves, height, diameter, and number of irrigations applied to each pot. Three-month data were collected and analyzed by using an RCBD design. After the trial, all the plants were exhausted, and soil samples were taken from the pots and brought to the RRI laboratory for the estimation of total biomass and carbon stocks. It was concluded that Clone AY-48 achieved the highest height among all the Populus deltoides varieties and stored more carbon stock in comparison to Italian and local poplar varieties. Farmyard manure had a positive influence on the height of the different Populus deltoides varieties. Clone AY-48 and Italian poplar plants are more suitable for rapidgrowth.
A Comprehensive Examination of UV-VIS Spectrophotometric Methods in Pharmaceutical Analysis Between 2015-2023
Authors: Eneş Duygu , Daştan Kerem , Kaplan Ozan , Çelebier Mustafa , Dogan Aysegul 
Published: May 2024

Background:
Quality control is a system of validated procedures in which many
samples, including active pharmaceutical ingredients and final products, are analyzed using
standard or validated analytical methods.

Method:
Analytical methods used in analyzing active pharmaceutical ingredients or final products
in the pharmaceutical industry can be methods registered in pharmacopeias and developed
by the company itself. For this reason, published papers related to pharmaceutical analysis attract
analysts and researchers' attention. In this study, pharmaceutical analysis and bioanalysis
studies carried out between 2015 and 2023 were examined using Google Scholar, and the recent
trends were determined for pharmaceutical analysis. Among the published papers performing
conventional analytical techniques for pharmaceutical analysis, those applying UV-VIS spectrophotometry
method were selected to predict a future perspective in this study. In addition to
the data obtained, the current situation of the pharmaceutical industry was considered to correlate
with the obtained data for pharmaceutical analysis.

Results:
The results were presented with comparative tables and summarizing graphs. Interpreting
the results allowed us to determine the trends that pharmaceutical analysis studies will lead
in the future. This study can be helpful for researchers working on pharmaceutical analysis in
both the industry and academia to predict future trends in pharmaceutical analysis. As a result of
the literature research covering the dates 2015-2023, 56% of UV-VIS Spectrophotometric
methods are used on pharmaceutical dosage forms, 27% are bulk, 16% are pure, 2% are biological
materials, and 0.4% are herbal. Made from materials. Of these studies, 28% were conducted
in the 200-240 nm range, 27% were conducted in the 240-300 nm range, and only 44% were
conducted at >300 nm. Interpreting the results allowed us to determine the trends that pharmaceutical
analysis studies will lead in the future.

Conclusion:
This study can be helpful for researchers working on pharmaceutical analysis in
both the industry and academy side to predict future trends for pharmaceutical analysis.
Recent Nanosolutions Based on Green Propolis Presenting Useful Medical
Applications
Authors: Policarpo Tonelli Fernanda Maria , Policarpo Tonelli Flávia Cristina , Lourenço Vitória de Oliveira , Pinto Geicielly da Costa 
Published: May 2024

Abstract::
Nanotechnology has the potential to offer elegant solutions to problems experienced
in the medical field, such as poor drug delivery efficiency and microbial resistance. In this sense,
it is interesting to associate nanomaterials with substances that also offer desirable properties to
favor human health. Green propolis is an example of a material that contains some of these useful
substances. The phenolic acids present in this type of propolis have already been proven to
present, for example, antimicrobial, immunostimulant, and antioxidant activities. In this minireview,
recent nano solutions, presented through manuscripts have been recently published
based on green propolis, receive attention due to their useful properties in the medical field.
Limitations to the clinical use of nanomaterials and the future prospects are also addressed.
Linguistic landscape and power representation at gas stations
Authors: Wahyuni Sri , Kurniati Ai , Susilawati Dyah 
Published: May 2024

Gas stations are hazardous, highly flammable public places. Thus, signs containing prohibitions, warnings, information, and road directions are needed to prevent catastrophes. This study aims to identify the linguistic system of the signs and describe the representation of power through the signs. The research site is gas stations in Semarang. This study uses observation methods in data collection by documenting, sorting, and classifying data using a national language, region, foreign, or both based on the linguistic system. Spolsky and Cooper's (1991) taxonomy of signs is used to classify the data. The categories are then examined further to reveal the embedded power relations. The results show that the linguistic landscape at the gas stations uses a monolingual system, Indonesian. This system demonstrates the gas station authorities' concern about prioritizing the state language in public spaces. Suggestions embedded in the signs do not explicitly represent power relations. However, they represent power by removing the subjects and objects on these signs. Texts of prohibitions and warnings should be created by involving more people so that the texts on the gas station LL can be more user-friendly.
Exploring User Experiences of the Mom2B mHealth Research App During the Perinatal Period: Qualitative Study
Authors: Bilal Ayesha-Mae , Pagoni Konstantina , Iliadis Stavros I , Papadopoulos Fotios C , Skalkidou Alkistis , Öster Caisa 
Published: May 2024

Background
Perinatal depression affects a significant number of women during pregnancy and after birth, and early identification is imperative for timely interventions and improved prognosis. Mobile apps offer the potential to overcome barriers to health care provision and facilitate clinical research. However, little is known about users’ perceptions and acceptability of these apps, particularly digital phenotyping and ecological momentary assessment apps, a relatively novel category of apps and approach to data collection. Understanding user’s concerns and the challenges they experience using the app will facilitate adoption and continued engagement.

Objective
This qualitative study explores the experiences and attitudes of users of the Mom2B mobile health (mHealth) research app (Uppsala University) during the perinatal period. In particular, we aimed to determine the acceptability of the app and any concerns about providing data through a mobile app.

Methods
Semistructured focus group interviews were conducted digitally in Swedish with 13 groups and a total of 41 participants. Participants had been active users of the Mom2B app for at least 6 weeks and included pregnant and postpartum women, both with and without depression symptomatology apparent in their last screening test. Interviews were recorded, transcribed verbatim, translated to English, and evaluated using inductive thematic analysis.

Results
Four themes were elicited: acceptability of sharing data, motivators and incentives, barriers to task completion, and user experience. Participants also gave suggestions for the improvement of features and user experience.

Conclusions
The study findings suggest that app-based digital phenotyping is a feasible and acceptable method of conducting research and health care delivery among perinatal women. The Mom2B app was perceived as an efficient and practical tool that facilitates engagement in research as well as allows users to monitor their well-being and receive general and personalized information related to the perinatal period. However, this study also highlights the importance of trustworthiness, accessibility, and prompt technical issue resolution in the development of future research apps in cooperation with end users. The study contributes to the growing body of literature on the usability and acceptability of mobile apps for research and ecological momentary assessment and underscores the need for continued research in this area.
Long-term impedance dynamics of cochlear implant electrodes in children
Authors: Zaitsev A.V. , Berezniuk V.V. , Berezniuk I.V. , Chornokur O.A. 
Published: May 2024

Background. Nowadays in Ukraine, there are about 3 thousand cochlear implant users, and their number is constantly increasing. The internal part of the implant remains in the cochlea throughout the patient’s life, but current data on the state of the electrodes in the long-term period are contradictory. The purpose was to study the impedance dynamics of cochlear implant electrodes during 5 years after surgery in children. Materials and methods. A retrospective study of 58 children with deafness after cochlear implantation was conducted. The changes in the interelectrode impedance and the relationship between them in the different parts of the electrode were evaluated and analyzed 1, 2, 3, and 5 years after the start of electrical stimulation. Results. At 1 year after the connection of the speech processor, an increase in the impedance was recorded in the basal part of the electrode (9–12 channels) relative to the medial and apical part of the cochlea. Over the next year, according to the electric field telemetry data, a significant (p < 0.05) downward trend was noted in the resistance in the basal part of the implant (9–12 electrodes). Within 2–5 years, a gradual decrease in the impedance in the medial and apical parts of the electrode occurred without statistically significant differences. In 29.3 % of cases, there was a tendency to a gradual increase in the impedance on 11–12 electrodes within 3–5 years after surgery. In another 8 patients (13.8 %), a critical increase in the impedance (> 15 kilohm) was detected on one of the contacts in the basal part of the electrode, which required their disconnection or correcting the settings of the speech processor. Conclusions. Regular monitoring of electrode impedance and electrical stimulation levels is recommended, especially during the first 2 years of implant use. This is necessary to improve the performance of the implant, to determine the most comfortable levels and thresholds of volume more accurately, which will improve the sound perception in children after cochlear implantation.