bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early outcome in renal transplantation from large donors to small and size‐matched recipients – A porcine experimental model
Authors: Ravlo Kristian , Chhoden Tashi , Søndergaard Peter , Secher Niels , Keller Anna K. , Pedersen Michael , Bibby Bo M. , Jørgensen Troels Munch , Møldrup Ulla , Østraat Ernst Øivind , Birn Henrik , Nørregaard Rikke , Marcussen Niels , Leuvenink Henri G. , Jespersen Bente 
Published: May 2012

Ravlo K, Chhoden T, Søndergaard P, Secher N, Keller AK, Pedersen M, Bibby BM, Møldrup U, Østraat EØ, Birn H, Nørregaard R, Marcussen N, Leuvenink HG, Jespersen B. Early outcome in renal transplantation from large donors to small and size‐matched recipients – A porcine experimental model.Abstract:  Kidney transplantation from a large donor to a small recipient, as in pediatric transplantation, is associated with an increased risk of thrombosis and DGF. We established a porcine model for renal transplantation from an adult donor to a small or size‐matched recipient with a high risk of DGF and studied GFR, RPP using MRI, and markers of kidney injury within 10 h after transplantation. After induction of BD, kidneys were removed from ∼63‐kg donors and kept in cold storage for ∼22 h until transplanted into small (∼15 kg, n = 8) or size‐matched (n = 8) recipients. A reduction in GFR was observed in small recipients within 60 min after reperfusion. Interestingly, this was associated with a significant reduction in medullary RPP, while there was no significant change in the size‐matched recipients. No difference was observed in urinary NGAL excretion between the groups. A significant higher level of HO‐1 mRNA was observed in small recipients than in donors and size‐matched recipients indicating cortical injury. Improvement in early graft perfusion may be a goal to improve short‐ and long‐term GFR and avoid graft thrombosis in pediatric recipients.
Surgical management of stem cell transplantation‐related complications in children
Authors: Lieber Justus , Hauch Holger , Lang Peter , Handgretinger Rupert , Blumenstock Gunnar , Seitz Guido , Warmann Steven W. , Fuchs Jörg 
Published: May 2012

Lieber J, Hauch H, Lang P, Handgretinger R, Blumenstock G, Seitz G, Warmann SW, Fuchs J. Surgical management of stem cell transplantation‐related complications in children.Abstract:  HSCT is an established treatment option for some children with life‐threatening diseases, but complications remain a major cause of morbidity and mortality. This retrospective data analysis addresses the surgical issues of children with HSCT‐related complications. Between 2002 and 2008, HSCT was performed in 240 children for leukemias/lymphomas (n=135), solid tumors (n=59), immunodeficiencies (n=20), lipid storage diseases (n=10), autoimmune diseases (n=9), and others (n=7). HSCT‐related complications requiring surgery occurred in 24 cases (10%) and most often in the leukemias/lymphomas group (18/24 cases): HC (cystoscopic irrigation, n=7), pulmonary aspergilloses (resection, n=7), bone necroses (core decompression, n=3), GvHD bowel (colostomy/PEG, n=2), ICH (drainage, n=2), bilateral kidney abscess (nephrectomies/renal transplantation, n=1), aspergillosis of the maxillary sinus (decompression, n=1), and post‐traumatic wound healing disorder (meshed skin transplantation, n=1). Survival was 50% in the group with surgery and 62% in the group without (p=0.275). Even though this difference was not statistically significant, surgical intervention should be encouraged in all cases to achieve favorable results.
Living donor liver transplantation from an asymptomatic mother who was a carrier for ornithine transcarbamylase deficiency
Authors: Wakiya T. , Sanada Y. , Urahashi T. , Ihara Y. , Yamada N. , Okada N. , Egami S. , Sakamoto K. , Murayama K. , Hakamada K. , Yasuda Y. , Mizuta K. 
Published: May 2012

Wakiya T, Sanada Y, Urahashi T, Ihara Y, Yamada N, Okada N, Egami S, Sakamoto K, Murayama K, Hakamada K, Yasuda Y, Mizuta K. Living donor liver transplantation from an asymptomatic mother who was a carrier for ornithine transcarbamylase deficiency.Abstract:  Liver transplantation (LT) has been adopted as a radical treatment for ornithine transcarbamylase deficiency (OTCD), yielding favorable outcomes. Despite the fact that it is an inheritable disease, a blood relative who is heterozygous for the disorder must sometimes be used as a liver donor for living donor LT. There is ongoing discussion regarding the use of heterozygous donors, however, to our knowledge, no cases where donation was determined based on the Ornithine transcarbamylase (OTC) activity before LT have been reported. Between May 2001 and April 2011, 17 patients were indicated for living donor LT because of OTCD at our facility. There were three cases with heterozygous donor candidate (17.6%). All heterozygous candidates underwent a liver biopsy to measure their OTC activity before LT and made efforts to secure the safety of the both donor and recipient. Two of 3 candidates had headaches sometimes, and their activity was less than 40%, and thus they were not employed as the donor. One candidate with 104.4% activity was employed, yielding favorable outcomes. Our current experience supported the effectiveness of our donation criteria, however it is necessary to collect sufficient data on a large number of patients to confirm the safety of the procedure.
Therapy management of cardiovascular adverse events in the context of targeted therapy for metastatic renal cell carcinoma
Authors: Schmidinger Manuela , Bergler‐Klein Jutta 
Published: May 2012

AbstractTargeted agents have significantly improved outcomes in patients with metastatic renal cell carcinoma, and are changing long‐term expectations in these patients. Experience with these agents highlights a distinct safety and tolerability profile, differing from that observed with conventional chemotherapy and radiotherapy. Cardiovascular adverse events have been observed when treating with targeted agents. This is of particular importance for patients with metastatic renal cell carcinoma who are elderly and present with significant comorbidities. A multidisciplinary approach and close collaboration between oncologists and cardiologists is essential for optimal management of cardiovascular adverse events. Strategies for the management of these adverse events include assessment of cardiovascular status at baseline and at regular intervals, patient education, and the use of supportive medication. Effective therapy management allows patients with cardiovascular adverse events to receive and continue targeted therapy with careful monitoring. Implementation of therapy management measures contributes towards maximizing treatment outcomes with targeted agents in patients with metastatic renal cell carcinoma.
Validity of assessing people experiencing mental illness who have offended using the Camberwell Assessment of Need–Forensic and Health of the Nation Outcome Scales–Secure
Authors: Abou‐Sinna Rana , Luebbers Stefan 
Published: May 2012

ABSTRACTEvidence‐based practices for forensic mental health services have been slow to develop, and there is a lack of measures that assess the mental health and criminogenic needs of people experiencing mental illness who have offended. The present study aimed to investigate the interrelationship between a clinician‐rated forensic mental health needs assessment (Health of the Nation Outcomes Scales–Secure (HoNOS‐S)), a forensic mental health needs assessment that considers both clinician and patient perspectives (Camberwell Assessment of Need–Forensic (CANFOR)), and measures of general and violent recidivism (Level Service–Case Management Inventory (LS‐CMI) and HCR‐20 Violence Risk Assessment Scheme (HCR‐20)). Needs were assessed for 72 forensic patients aged between 20 and 62 years of age, located in a secure forensic mental health facility. The findings revealed significant positive correlations between the HoNOS‐S, CANFOR, and HCR‐20. Only the CANFOR was positively correlated with the LS‐CMI, and uniquely contributed variance to the HCR‐20. Patients and nurses differed in the total number of needs and met needs they identified as present. The findings suggest that the collaborative approach of the CANFOR might be more appropriate for measuring outcomes in the treatment of individuals experiencing mental illness who have offended.
Equine subepithelial keratomycosis
Authors: Brooks Dennis E. , Plummer Caryn E. , Mangan Brendan G. , Ben‐Shlomo Gil 
Published: May 2012

AbstractObjective  To describe clinical findings in equine subepithelial keratomycosis (SEK).Design  Retrospective medical records study.Animals studied  Medical records of horses that had subepithelial keratomycosis (SEK) at the University of Florida Veterinary Medical Center from 2007 to 2011 were reviewed.Procedures  Data collected from the medical records included signalment, clinical descriptions of ocular lesions, diagnostic techniques, and therapeutic outcomes.Results  Twenty‐one horses, consisting of three Quarter horse geldings, two Morgan geldings, one Morgan mare, two Arabian mares, three Arabian geldings, two warm blood mares, two warm blood geldings, two Thoroughbred geldings, one Thoroughbred mare, one Appaloosa mare, one Holsteiner gelding, and one Holsteiner mare with SEK were identified. Multifocal punctate and/or geographic patterns of subepithelial opacification were present in all eyes. Intermittent phases of weak fluorescein and/or rose Bengal dye were found in 16 eyes. Clinical signs of iridocyclitis were absent in all eyes. Cytologic confirmation of fungi was found in ten cases, Candida was cultured from one eye, and Aspergillus cultured in three eyes. Nineteen of 21 eyes with SEK resolved when topical antifungal therapy was initiated. Two of the 19 responding eyes recurred and required additional therapy, and two other eyes progressed to ulcerative keratomycosis.Conclusions  This is the first clinical report of a subtle form of keratomycosis in the horse. Subepithelial keratomycosis may be a distinct clinical entity or represent a continuum in the described forms of equine keratomycosis.
Clinimetrics of measures of oropharyngeal dysphagia for preschool children with cerebral palsy and neurodevelopmental disabilities: a systematic review
Authors: BENFER KATHERINE A , WEIR KELLY A , BOYD ROSLYN N 
Published: May 2012

Aim  The aim of this study was to determine the psychometric properties and clinical utility of objective measures of oropharyngeal dysphagia (OPD) in children with cerebral palsy or neurodevelopmental disabilities aged 12 months to 5 years.Method  Five electronic databases were searched to identify measures of OPD. The Consensus‐based Standards for the Selection of Measurement Instruments (COSMIN) Checklist was used to assess psychometric properties and a Modified CanChild Outcome Rating Form was used for clinical utility.Results  Nine measures of OPD from 27 papers were assessed: the Brief Assessment of Motor Function – Oral Motor Deglutition Scale; the Behavioral Assessment Scale of Oral Functions in Feeding; the Dysphagia Disorders Survey; the Feeding Behaviour Scale; the Functional Feeding Assessment, modified; the Gisel Video Assessment; the Oral Motor Assessment Scale; the Pre‐Speech Assessment Scale; and the Schedule for Oral Motor Assessment.Interpretation  The Schedule for Oral Motor Assessment and the Functional Feeding Assessment, modified, proved to be the strongest measures based on published psychometric properties of validity and reliability. The Schedule for Oral Motor Assessment and the Dysphagia Disorders Survey were found to have the strongest clinical utility. Further studies to test the psychometric properties of existing measures, in particular predictive validity, responsiveness, and test–retest reliability, would be beneficial for selecting an appropriate measure for both clinical and research contexts.
Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters
Authors: Douglas Lu Weiya , Funkelstein Lydiane , Toneff Thomas , Reinheckel Thomas , Peters Christoph , Hook Vivian 
Published: May 2012

J. Neurochem. (2012) 122, 512–522.AbstractPeptide neurotransmitters function as key intercellular signaling molecules in the nervous system. These peptides are generated in secretory vesicles from proneuropeptides by proteolytic processing at dibasic residues, followed by removal of N‐ and/or C‐terminal basic residues to form active peptides. Enkephalin biosynthesis from proenkephalin utilizes the cysteine protease cathepsin L and the subtilisin‐like prohormone convertase 2 (PC2). Cathepsin L generates peptide intermediates with N‐terminal basic residue extensions, which must be removed by an aminopeptidase. In this study, we identified cathepsin H as an aminopeptidase in secretory vesicles that produces (Met)enkephalin (ME) by sequential removal of basic residues from KR‐ME and KK‐ME, supported by in vivo knockout of the cathepsin H gene. Localization of cathepsin H in secretory vesicles was demonstrated by immunoelectron microscopy and immunofluorescence deconvolution microscopy. Purified human cathepsin H sequentially removes N‐terminal basic residues to generate ME, with peptide products characterized by nano‐LC‐MS/MS tandem mass spectrometry. Cathepsin H shows highest activities for cleaving N‐terminal basic residues (Arg and Lys) among amino acid fluorogenic substrates. Notably, knockout of the cathepsin H gene results in reduction of ME in mouse brain. Cathepsin H deficient mice also show a substantial decrease in galanin peptide neurotransmitter levels in brain. These results illustrate a role for cathepsin H as an aminopeptidase for enkephalin and galanin peptide neurotransmitter production.
Longitudinal assessment of distress and quality of life in the early stages of breast cancer treatment
Authors: Costa‐Requena Gema , Rodríguez Ana , Fernández‐Ortega Paz 
Published: May 2012

Scand J Caring Sci; 2013; 27; 77–83

Longitudinal assessment of distress and quality of life in the early stages of breast cancer treatment
AbstractBackground:  During breast cancer treatment, a decline in quality of life and the patient’s psychological well‐being is observed. The purpose of this study was to assess levels of quality of life and psychological distress during breast cancer treatment.Methods:  Utilizing a longitudinal design, patients with breast cancer were assessed at three time‐points during treatment. The within‐subject analysis of variance was conducted to compare subscales of quality of life. Linear regression analyses were utilized to determine the contribution of psychological distress to the quality of life at each time assessment.Results:  Significant differences between the assessment times on the physical subscale (p < 0.001), socio‐family (p < 0.01) and emotional well‐being (p < 0.001) were showed. Specific domain‐related breast cancer and psychological distress (p < 0.05) were significant during the assessment period. No difference was found on the total quality of life score within the three points of reference for treatment. The regression analysis revealed that after treatment, psychological distress showed a higher percentage of variance of the quality of life (62.6%) compared to other treatment time‐points.Conclusions:  Significant changes to the quality of life and psychological distress subscales are seen during breast cancer treatment. The degree to which psychological distress affected quality of life varied over the illness continuum. Health professionals should pay attention to the variability of the emotional support and care needs of patients with cancer at different times of treatment.
The housekeeping gene YWHAZ remains stable in a model of developmentally primed non‐alcoholic fatty liver disease
Authors: Bruce Kimberley D. , Sihota Kiran K. , Byrne Christopher D. , Cagampang Felino R. 
Published: May 2012

AbstractBackgroundNon‐alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in Western society. Comparative gene expression studies are beginning to elucidate the molecular mechanisms underlying NAFLD progression. We have previously shown that high fat diets during early life can prime non‐alcoholic steatohepatitis (NASH) in adulthood, through lipogenesis gene elevation. To generate accurate results in such studies, appropriate housekeeping genes (HKG) which are unaffected by disease processes, are used for data normalisation. However, there is little existing data to show the effects of NAFLD on HKG expression.AimsTo identify the HKG in a mouse model of developmentally primed NAFLD and NASH, which maintains expression stability.MethodsWe determined the expression stability of six candidates HKG (GAPDH, YWHAZ, B2M, EIF4A2, ACTB and CYC1) in a mouse model of developmentally primed NAFLD in both the day and night, using geNORM qBasePlus software.Results
HKG expression differed across dietary groups and time of day. In the majority of treatment groups and time points the most stable gene was YWHAZ. Following high fat diet interventions CYC1 became notably unstable. Overall the effect of NAFLD and NASH on HKG expression was to maintain stability of YWHAZ, but destabilise CYC1 and EIF4A2.ConclusionsOur data clearly shows that HKG expression is affected by NAFLD severity and time of day sampling, highlighting the importance of suitable HKG gene selection. For comparative gene expression studies investigating NAFLD we would recommend use of YWHAZ as a robust, stably expressed HKG.
Prevalence and Clinicopathologic Characteristics of Gastric Cardia Cancer in South Korea
Authors: Kim Ji Yeon , Lee Hye Seung , Kim Nayoung , Shin Cheol Min , Lee Sang Hyub , Park Young Soo , Hwang Jin‐Hyeok , Kim Jin‐Wook , Jeong Sook‐Hyang , Lee Dong Ho , Park Do Joong , Kim Hyung Ho , Jung Hyun Chae 
Published: May 2012

AbstractBackground and Aim:  Western reports have suggested that the prevalence of gastric cardia cancer (GCC) has been increasing, and indicated some differences between GCC and gastric noncardia cancer (GNCC). However, few studies have been conducted in Asia. The aims of this study were to estimate the prevalence of GCC and to evaluate differences of clinicopathologic characteristics between GCC and GNCC in South Korea.Methods:  This study was single‐center case–control study. A total of 829 patients with gastric cancer and 270 controls were enrolled between 2003 and 2011. Baseline characteristics, Helicobacter pylori (H. pylori) infection status, and histologic characteristics were compared among three groups (GCC, GNCC, and control).Results:  Sixty cases (7.2%) of gastric cancer were located in cardia. Multivariate analysis showed that male odds ratio (OR, 5.72; 95% CI, 1.72–19.07; p = .005) and cigarette smoking (OR, 5.38; 95% CI, 1.39–20.90; p = .015) were risk factors of GCC in comparison with control group, but H. pylori infection rate was not significant. In the case of GNCC, cigarette smoking (OR, 3.87; 95% CI, 1.81–8.29; p < .001), past alcohol intake (OR, 2.82; 95% CI, 1.28–6.20; p = .010), intestinal metaplasia (OR, 3.22; 95% CI, 2.00–5.17; p < .001), and H. pylori infection (OR, 3.06; 95% CI, 1.90–4.93; p < .001) were risk factors of GNCC. Gastroesophageal reflux disease symptoms were higher in the GNCC (21.2%) than control group (13.5%) (p = .008). However, in the case of GCC, they were similar between the GCC (12.7%) and control group (p = .872). According to multivariate analysis, history of H. pylori eradication (OR, 0.34; 95% CI, 0.19–0.61; p < .001) was associated with a protective effect on GNCC. GCC showed higher depth of invasion (p = .038) and frequent distant metastasis (p = .012) than GNCC.Conclusion:  In this referral center based study, the prevalence of GCC was 7.2% in South Korea. Risk factors and clinicopathologic characteristics for GCC and GNCC were different, supporting that the pathophysiology is different in the development of GCC and GNCC.
Garnet and spinel lherzolite assemblages in MgO–Al2O3–SiO2 and CaO–MgO–Al2O3–SiO2: thermodynamic models and an experimental conflict
Authors: Green E. C. R. , Holland T. J. B. , Powell R. , White R. W. 
Published: May 2012

AbstractThe recent publication of an updated thermodynamic dataset for petrological calculations provides an opportunity to illustrate the relationship between experimental data and the dataset, in the context of a new set of activity–composition models for several key minerals. These models represent orthopyroxene, clinopyroxene and garnet in the system CaO–MgO–Al2O3–SiO2 (CMAS), and are valid up to 50 kbar and at least 1800 °C; they are the first high‐temperature models for these phases to be developed for the Holland & Powell dataset. The models are calibrated with reference to phase‐relation data in the subsystems CaO–MgO–SiO2 (CMS) and MgO–Al2O3–SiO2 (MAS), and will themselves form the basis of models in larger systems, suitable for calculating phase equilibria in the crust and mantle. In the course of calibrating the models, it was necessary to consider the reaction orthopyroxene + clinopyroxene + spinel = garnet + forsterite in CMAS, representing a univariant transition between simple spinel and garnet lherzolite assemblages. The high‐temperature segment of this reaction has been much disputed. We offer a powerful thermodynamic argument relating this reaction to the equivalent reaction in MAS, that forces us to choose between good model fits to the data in MAS or to the more recent data in CMAS. We favour the fit to the MAS data, preserving conformity with a large body of experimental and thermodynamic data that are incorporated as constraints on the activity–composition modelling via the internally consistent thermodynamic dataset.
Cognitive functioning and age at onset in non‐affective psychotic disorder
Authors: van der Werf M. , Köhler S. , Verkaaik M. , Verhey F. , van Os J. ,   GROUP Investigators
Published: May 2012

van der Werf M, Köhler S, Verkaaik M, Verhey F, van Os J, GROUP Investigators. Cognitive functioning and age at onset in non‐affective psychotic disorder.Objective:  Age at psychosis onset has been related to variability in cognitive functioning, but its effect may be mediated by demographic and clinical factors. The aim of the current study was to study the contribution of age at onset, as well as demographic and illness characteristics, to variation in cognitive functioning in patients with schizophrenia spectrum disorder.Method:  Patients (n = 1053) and healthy controls (n = 631) underwent comprehensive neuropsychological and clinical assessments. The effect of age at onset on age‐standardized cognitive test scores was assessed with multiple linear regression analyses. Mediation by illness and demographic factors was tested using a multiple mediation Sobel test.Results:  A diagnosis of schizophrenia, higher antipsychotic dose, and more negative symptoms were associated with earlier onset of illness, while female sex and a more chronic course were associated with later illness onset. Furthermore, earlier onset was associated with worse performance on immediate recall and sustained attention. However, male sex, more negative symptoms, and higher antipsychotic dose mediated the effect of age at onset on memory, while negative symptoms explained its association with attention/vigilance.Conclusion:  Greater impairment in memory and attention in early‐onset psychosis may be explained by features indicative of underlying neurodevelopmental vulnerability.