bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in cognitive‐emotional and physiological symptoms of depression following STN‐DBS for the treatment of Parkinson’s disease
Authors: Strutt A. M. , Simpson R. , Jankovic J. , York M. K. 
Published: June 2011

Background and purpose:  Subthalamic nucleus deep brain stimulation (STN‐DBS) has been shown to have beneficial effects on the motor features of Parkinson’s disease (PD), but its impact on non‐motor symptoms, most notably mood, has not been fully explored.Methods:  In the first study to independently compare the emotional‐cognitive and somatic/physiological symptoms of depression, we examined mood differences in 17 bilateral STN‐DBS and 22 matched non‐surgical PD patients at baseline and 6 months.Results:  The STN‐DBS group reported higher levels of depression at baseline with significant endorsement of physical symptomatology. Postoperatively, no significant between‐group differences in physical symptoms of depression were found. In contrast, a significant group by time interaction for cognitive‐emotional symptoms of depression was found, with the STN‐DBS group reporting an increase in psychological symptoms of distress. The STN‐DBS group also reported an increase in anxiety following surgery. The suicide rate of 5% found in our study is consistent with other postoperative studies in PD. The impact of changes in levodopa and psychotropic medication are also explored.Conclusions:  Preliminary results suggest that the motor improvement often observed in patients with PD following bilateral STN‐DBS may be partially offset by an increase in affective‐cognitive symptoms of depression.
The impact of political violence on psychosocial functioning of individuals and families: the case of palestinian adolescents
Authors: Al‐Krenawi Alean , Graham John R. 
Published: June 2011

Background:  The impact of political violence on the psychosocial functioning of adolescents and their families was compared for surveyed populations from two regions of Palestine.Method:  A randomly‐selected sample of 971 adolescents (521 from the West Bank and 450 from the Gaza Strip regions, 42% male/57% female) completed scales measuring traumatic event, post‐traumatic stress disorder (PTSD), peer relations, mental health, aggression, and family functioning.Results:  (1) West Bank participants reported a significantly higher level of exposure to political violence and significantly more aggression, mental health symptoms, problems in family and social functioning; (2) Participants exposed to greater political violence reported higher levels of depression, hostility, paranoid ideation, and PTSD; (3) Economic status and level of parental education were related to reduced levels of mental health symptoms and greater family functioning; (4) There were gendered differences.Conclusions:  The study provides a starting point to begin to compare the experiences and outcomes between Palestinian adolescents in the West Bank and Gaza Strip and a basis for considering implications for service delivery and policy makers concerned with the well being of Palestinian communities.
Integrating carrier selection with supplier selection decisions to improve supply chain security
Authors: Meixell Mary J. , Norbis Mario 
Published: June 2011

AbstractSupply chain security is a major concern for logistics managers who have responsibility for inbound and outbound shipments to and from both domestic and international locations. We propose here that logistics decisions concerning security in the supply chain will be made more effectively when made in concert with decisions in related supply chain processes, especially supplier and carrier selection. Indeed, managers may minimize cost, transit time, and security risk by integrating decision processes internally, as well as with their carrier's and supplier's operations. Thus, we account for both intra‐firm collaboration between logistics and purchasing managers, as well as inter‐firm collaboration among buyers, suppliers, and carriers in a supply chain. In this paper, we propose a decision process that features a set of security rules and a multi‐objective optimization model to accomplish this aim. We then provide an illustration to demonstrate the potential usefulness of these concepts in practice.
A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt
Authors: Sievert William , Altraif Ibrahim , Razavi Homie A. , Abdo Ayman , Ahmed Ezzat Ali , AlOmair Ahmed , Amarapurkar Deepak , Chen Chien‐Hung , Dou Xiaoguang , El Khayat Hisham , elShazly Mohamed , Esmat Gamal , Guan Richard , Han Kwang‐Hyub , Koike Kazuhiko , Largen Angela , McCaughan Geoff , Mogawer Sherif , Monis Ali , Nawaz Arif , Piratvisuth Teerha , Sanai Faisal M. , Sharara Ala I. , Sibbel Scott , Sood Ajit , Suh Dong Jin , Wallace Carolyn , Young Kendra , Negro Francesco 
Published: June 2011

AbstractBackground: The hepatitis C pandemic has been systematically studied and characterized in North America and Europe, but this important public health problem has not received equivalent attention in other regions.Aim: The objective of this systematic review was to characterize hepatitis C virus (HCV) epidemiology in selected countries of Asia, Australia and Egypt, i.e. in a geographical area inhabited by over 40% of the global population.Methodology: Data references were identified through indexed journals and non‐indexed sources. In this work, 7770 articles were reviewed and 690 were selected based on their relevance.Results: We estimated that 49.3–64.0 million adults in Asia, Australia and Egypt are anti‐HCV positive. China alone has more HCV infections than all of Europe or the Americas. While most countries had prevalence rates from 1 to 2% we documented several with relatively high prevalence rates, including Egypt (15%), Pakistan (4.7%) and Taiwan (4.4%). Nosocomial infection, blood transfusion (before screening) and injection drug use were identified as common risk factors in the region. Genotype 1 was common in Australia, China, Taiwan and other countries in North Asia, while genotype 6 was found in Vietnam and other Southeast Asian countries. In India and Pakistan genotype 3 was predominant, while genotype 4 was found in Middle Eastern countries such as Egypt, Saudi Arabia and Syria.Conclusion: We recommend implementation of surveillance systems to guide effective public health policy that may lead to the eventual curtailment of the spread of this pandemic infection.
Does ERP Hands‐On Experience Help Students Learning Business Process Concepts?
Authors: Rienzo Thomas , Han Bernard 
Published: June 2011

ABSTRACTOver the past decade, more and more business schools are attempting to teach business processes (BPs) by using enterprise resource planning (ERP) software in their curricula. Currently, most studies involving ERP software in the academy have concentrated on learning and teaching via self‐assessment surveys or curriculum integration. This research extended previous studies by attempting to measure student knowledge acquisition of BP concepts (BPC) about two common BP cycles through hands‐on exercises using ERP software. Assessments of students’ knowledge about BP were conducted at multiple time points during the study. In addition, a Technology Acceptance Model (TAM)‐based survey was employed to analyze student self‐assessment about improved understanding of BPs though ERP hands‐on exercises. Results from our empirical study indicated that there is no clear evidence that students’ knowledge about BPs significantly improved after experiencing ERP software. However, students’ self‐assessment showed that there is a positive relationship between their comprehension of BPs and hands‐on experience with ERP software. Our research findings concurred with previous research, and studies undertaken in other disciplines.
Achieving treatment goals of reducing or maintaining body iron burden with deferasirox in patients with β‐thalassaemia: results from the ESCALATOR study
Authors: Taher Ali , Elalfy Mohsen S. , Al Zir Kusai , Daar Shahina , Al Jefri Abdullah , Habr Dany , Kriemler‐Krahn Ulrike , Roubert Bernard , El‐Beshlawy Amal 
Published: June 2011

AbstractThis analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron‐overloaded patients with β‐thalassaemia from the ESCALATOR trial (n = 231). Mean liver iron concentrations (LIC) decreased significantly from 21.1 ± 8.2 to 14.2 ± 12.1 mg Fe/g dry weight (dw) at 2 yr (P < 0.001) in patients with LIC ≥7 mg Fe/g dw at baseline; patients with LIC <7 mg Fe/g dw maintained these levels over the treatment period. The proportion of patients with LIC <7 mg Fe/g dw increased from 9.4% at core baseline to 39.3% by the end of year 2. The results showed that deferasirox enabled therapeutic goals to be achieved, by maintaining LIC in patients with LIC <7 mg Fe/g dw at a mean dose of 22.4 ± 5.2 mg/kg/d and significantly reducing LIC in patients with LIC ≥7 mg Fe/g dw at a mean dose of 25.7 ± 4.2 mg/kg/d, along with a manageable safety profile.
Responsiveness and minimal important score differences in quality‐of‐life questionnaires: a comparison of the EORTC QLQ‐C30 cancer‐specific questionnaire to the generic utility questionnaires EQ‐5D and 15D in patients with multiple myeloma
Authors: Kvam Ann Kristin , Fayers Peter M. , Wisloff Finn 
Published: June 2011

AbstractObjectives: The aims of this study were to (i) compare the responsiveness of the EORTC QLQ‐C30 cancer‐specific questionnaire and the generic questionnaires EQ‐5D and 15D used for economic evaluation of healthcare interventions and (ii) determine the minimal important differences (MIDs) in these questionnaires. The MID is the smallest change in a quality‐of‐life score considered important to patients.Methods: Between 2006 and 2008, 239 patients with multiple myeloma completed the questionnaires at inclusion (T1) and after 3 months (T2). At T2, patients were asked whether they had noticed any change in their quality of life. Responsiveness and MIDs were determined by mean score changes (T2–T1) for patients who, in the interview, stated they hadimproved, deteriorated, or wereunchanged.Responsiveness was also assessed using standardized response means. Wilcoxon tests for pair differences were used to evaluate the statistical significance of the changes.Results: Patients whoimprovedhad significantly (P < 0.01) higher scores at T2 in all three questionnaires. Patients whodeterioratedreported lower scores at T2; however, for the 15D, the differences in score were not statistically significant. The MIDs for the QLQ‐C30, EQ‐5D, and 15D were 8, 0.08, and 0.03 in patients whoimprovedand 12, 0.10 and 0.02 in patients whodeteriorated, respectively.Conclusions: All three questionnaires showed an acceptable responsiveness in patients whoimproved. However, the 15D did not respond optimally in patients whodeteriorateand cannot be recommended for use in patients with myeloma.
A novel mutation in the OFD1 (Cxorf5) gene may contribute to oral phenotype in patients with oral‐facial‐digital syndrome type 1
Authors: Diz P , Álvarez‐Iglesias V , Feijoo JF , Limeres J , Seoane J , Tomás I , Carracedo A 
Published: June 2011

Oral Diseases (2011) 17, 610–614Background:  Oral‐facial‐digital syndrome (OFDS) type 1 (OFD1) is an X‐linked dominant condition associated with embryonic male lethality. It almost always affects the oral cavity, face, and digits. It is considered to be a ciliopathy caused by mutations in the OFD1 gene. A variety of mutations have been described, and a genotype–phenotype correlation has been suggested.Objective and Methods:  The proband was an 8‐year‐old Spanish girl with suspected OFD1. We extended the pedigree to three proband’s generations, performing a thorough physical examination and screening for OFD1 mutations in nine individuals.Results:  The proband, her mother, and her sister showed oral findings consistent with OFD1. Ultrasound evaluation revealed the existence of renal cysts only in the proband’s mother. The rest of the family (all male) had no relevant morphological abnormalities. A single‐base deletion in exon 16 of OFD1 (c.2183delG) leading to a frameshift was detected in the proband, her mother, and her sister.Conclusion:  Because all three women had a similar oral phenotype, this new mutation might be involved in the development of the OFD1 oral manifestations. In cases of OFDS, physical examination (including the oral cavity and renal function) and genetic screening of the probands and their relatives are mandatory.
Diabetes affects statherin expression in human labial glands
Authors: Isola M , Lantini MS , Solinas P , Diana M , Isola R , Loy F , Cossu M 
Published: June 2011

Oral Diseases (2011) 17, 685–689Background and Objective:  Salivary statherin, which plays a special role in the defense of tooth integrity, is secreted by both major and minor salivary glands. A significantly reduced expression of this was recently found in human major salivary glands removed from diabetic subjects and was correlated with the high incidence of dental diseases occurring in patients with diabetes. In this study, we measured the density of gold particles indicating statherin immunoreactivity in labial glands to reveal a significant difference between diabetic and non‐diabetic patients.Materials and Methods:  Surgical samples of labial glands obtained from both diabetic and non‐diabetic patients were fixed with a glutaraldehyde and paraformaldehyde mixture, embedded in Epon, and treated for immunogold histochemistry using a polyclonal antibody specific for statherin.Results:  Statherin immunoreactivity was detected onto small vesicles diffused throughout the cytoplasm of serous cells. Statistical analysis revealed that the number of stained particles was significantly lower in the samples from diabetic subjects than from non‐diabetic subjects.Conclusions:  The results indicate that diabetes affects statherin secretion in labial glands and support the hypothesis that the increased susceptibility to oral diseases associated with diabetes could be related with a reduced statherin secretion.
Functional splicing assay of DSPP mutations in hereditary dentin defects
Authors: Lee K‐E , Lee S‐K , Jung S‐E , Lee ZH , Kim J‐W 
Published: June 2011

Oral Diseases (2011) 17, 690–695Objective:  Dentin sialophosphoprotein (DSPP) gene mutations have been identified in isolated hereditary dentin defects; however, the genotype–phenotype correlations are poorly understood. We performed in vitro splicing assays to test the hypothesis that DSPP mutations in splice junctions as well as proposed missense/nonsense mutations experimentally result in aberrant pre‐mRNA splicing.Materials and methods:  The genomic fragment of the human DSPP gene was cloned into the pSPL3 splicing vector, and previously reported as well as informative de novo mutations were then introduced by PCR mutagenesis. The COS‐7 cells were transfected with each plasmid vector, and total RNA was isolated. RT‐PCR result was analyzed, and the band intensity of the product was calibrated using ImageJ.Results:  The predictions by others of exon 3 skipping in specific DSPP mutations have been validated and a cryptic splicing donor site has been identified. However, the degree of mutational effect on pre‐mRNA splicing varied considerably depending on the changed nucleotide.Conclusions:  The predictions of exon 3 skipping in specific DSPP mutations have been validated, and a cryptic splicing donor site has been identified. Our data may provide insight into the contribution of DSPP mutations in the pathogenesis and genotype–phenotype correlations of hereditary dentin defects.
USE OF A CONTROLLED CHLORINE DIOXIDE (CLO2) RELEASE SYSTEM IN COMBINATION WITH MODIFIED ATMOSPHERE PACKAGING (MAP) TO CONTROL THE GROWTH OF PATHOGENS
Authors: SHIN JOONGMIN , HARTE BRUCE , SELKE SUSAN , LEE YOUNSUK 
Published: June 2011

ABSTRACT Salmonella Typhimurium and Listeria monocytogenes are major bacterial pathogens associated with poultry products. A controlled released ClO2 sachet applied with modified atmosphere packaging (MAP) was evaluated for its ability to control the growth of S. Typhimurium and L. monocytogenes on raw chicken breast during refrigerated storage. The fresh chicken samples were inoculated with one or the other of the pathogens at 104 cfu/g, and the packages (with and without ClO2 sachet) were flushed with ambient air or 30% CO2/70% N2 before sealing, and then stored at 4C for up to 21 days. The maximum reduction in MAP plus ClO2 (compared with MAP alone) was 0.68 log cfu/g for S. Typhimurium and 1.87 log cfu/g for L. monocytogenes. Color and pH changes of the chicken breast were observed at 8 µg/h of ClO2 during the storage period.PRACTICAL APPLICATIONSWe think that the results of the study with the combined treatment of chlorine dioxide (ClO2) and modified atmosphere packaging may enhance the effectiveness of antimicrobials, reduce the amount of agent needed, and decrease the risk of off‐flavors. The applications of the results will be useful for poultry industry to give the significant improvement in shelf life for packaged fresh products.
EFFECTS OF DIFFERENT SALT CONTENTS ON SOME QUALITY CHARACTERISTICS DURING PROCESSING OF DRY‐CURED TURKISH PASTIRMA
Authors: UĞUZ ŞEVKAT , SOYER AYLA , DALMIŞ ÜLKÜ 
Published: June 2011

ABSTRACTThis study examined the effects of different salt contents (3, 6 and 9%) during process stages on physicochemical, lipid oxidation and microbial quality of a dry‐cured meat product, pastırma, throughout 21 days of processing. Significant changes in moisture content, NaCl content, pH and water activity (aw) were observed in pastırma after the third drying and pasting stages. There were significant decreases (P < 0.05) in objective color characteristics (L*, a* and b*) between raw material and final product for all pastırma samples. However, no significant effect of salt level (P > 0.05) was detected on L* and a*. Salt level significantly (P < 0.05) affected thiobarbituric acid‐reactive substances (TBARS) formation, which was lower in low‐salt pastırma samples, while the combination of salting, drying and pressing stages increased TBARS values in high‐salt pastırma samples. Higher salt content (6% and 9%) and last drying resulted in reduction of microbial count.PRACTICAL APPLICATIONSSalt (NaCl) is an important agent in inhibiting microbial growth, reducing water activity and imparting a salty taste to dry‐cured meat products such as ham and pastırma. Salt content in pastırma varies from 5% to 10% in the final product and has an impact on product quality parameters. The effects of different NaCl contents (3, 6 and 9%) and processing stages on pH, water activity (aw), color parameters, lipid oxidation and microbial count were studied during processing of pastırma. Low‐salt concentration had some negative impacts on pastırma characteristics, giving high aw, pH and microbial count, but low Thiobarbituric acid‐reactive substances value and NaCl content. Drying, pressing and pasting with çemen mixture during pastırma processing had a positive impact on reduction of moisture, aw and microbial count.
DETERMINATION AND PREDICTION OF ODOR THRESHOLDS FOR ODOR ACTIVE VOLATILES IN A NEUTRAL APPLE JUICE MATRIX
Authors: CLIFF MARGARET , STANICH KAREEN , TRUJILLO JUDITH MORAN , TOIVONEN PETER , FORNEY CHARLES F. 
Published: June 2011

ABSTRACTOdor thresholds were determined for 10 odor active compounds (OAC) in apple juice, using three‐alternate forced choice methodology. Thresholds were determined in a neutral juice matrix by 25–30 panelists in duplicate at 22C. Individual thresholds were calculated using the best estimate threshold method. Group thresholds were determined using the geometric mean of the individual thresholds. OAC differed substantially in their concentration ranges, aroma thresholds (0.06–5.49 µL/L) and response rates (1.5–234.5% correct response/[µL/L]). Juice thresholds exceeded water thresholds by ∼5–600 times. Multiple linear regressions were used to develop models to predict juice thresholds from water thresholds and physical constants, for apple juice (AJ) and published orange juice (OJ) values. The simplest most practical models utilized just one variable, the logarithm of the water threshold. Coefficients of correlation (R2) for the AJ and OJ models were 71.7 and 72.8%, respectively, and provided satisfactory estimates of juice thresholds.PRACTICAL APPLICATIONSThis research established aroma thresholds in a juice matrix for 10 prevalent esters in apples and related them to water thresholds using log models. These thresholds allow industry to calculate more realistic odor activity values for quality control and research purposes in the apple juice industry.
PROTEOLYTIC CHANGES DURING PROCESSING IN TURKISH DRY‐CURED MEAT PRODUCT (PASTIRMA) WITH DIFFERENT SALT LEVELS
Authors: SOYER AYLA , UĞUZ ŞEVKAT , DALMIŞ ÜLKÜ 
Published: June 2011

ABSTRACTThe effects of different salt (NaCl) contents on proteolytic changes during processing in the dry‐cured meat product pastırma were investigated. Pastırma samples were produced with three different NaCl levels (3, 6 and 9%) and proteolytic changes were monitored.A progressive increase in nonprotein nitrogen (NPN) and free amino acids (FAAs) was detected during processing. High‐salt pastırma samples had the highest FAAs. Drying and pressing stages before pasting with çemen resulted in a decrease in water‐soluble nitrogen (WSN) and a slight increase in NPN and FAA. High salt level and processing time resulted in the accumulation of FAAs. The increase in WSN, NPN and FAA contents after çemen treatment indicated that the çemen used in the pasting process had an impact on accumulation of these components in pastırma. However, no significant effect of salt level was observed on WSN and NPN. Sarcoplasmic proteins decreased considerably after salting due to drainage. Myofibrillar proteins degraded during processing, particularly in samples with 6 and 9% NaCl.PRACTICAL APPLICATIONSProteolysis is one of the most important biochemical changes occurring during the processing of dry‐cured meat products such as ham or pastırma. The effect of additional salt concentrations and processing stages on proteolysis in Turkish dry‐cured meat product, pastırma, was studied during processing. Processing stages (salting, drying, pressing and pasting with çemen mixture) resulted in increases in NPN and FAA contents. High salt level (9% NaCl) and processing stages, particularly pasting with çemen mixture, facilitated the accumulation of FAA. Salting resulted in denaturation or insolubilization of proteins. Insolubilization of sarcoplasmic proteins was clearly seen in samples with 6 and 9% NaCl, depending on increased salt concentration during processing. In contrast, myofibrillar proteins in samples with 6 and 9% NaCl degraded during processing. From these results, processing conditions (salt concentration of pastırma and pasting with çemen) can determine the compounds released from protein breakdown during processing.