bluuebunny/crossref_metadata_2025_split huggingface dataset:
Locusta migratoria hydrolysates attenuate lipopolysaccharide (LPS)/D-Galactosamine (D-Gal)-induced cytotoxicity and inflammation in Hep G2 cells via NF-κB signaling suppression
Authors: Zheng Jiaxiang , Jung Sunyoon , Ha Jung-Heun , Jeong Yoonhwa 
Published: May 2024

AbstractThe prolonged state of hepatic inflammation can lead to liver damage, a critical driving force in the progression of liver-related diseases. Locusta migratoria (LM), an edible insect, is recognized for its protein richness and potential to produce a range of bioactive polypeptides, presenting a novel solution for liver disease. This study investigated the hepatoprotective effects of LM hydrolysates in human hepatoma G2 (Hep G2) cells challenged with lipopolysaccharide (LPS)/D-Galactosamine (D-Gal), a model of liver injury. Remarkably, LM hydrolysates significantly ameliorated cell damage, as evidenced by the inhibition of the LPS/D-Gal-induced decrease in cell viability and reduction in lactate dehydrogenase (LDH) release. Furthermore, LM hydrolysates alleviated the release of aspartate aminotransferase (AST) from cells exposed to LPS/D-Gal and lowered the secretion of inflammatory cytokines while suppressing the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a key pathway in inflammation. In particular, LM-N hydrolysate mitigated hepatotoxicity by attenuation of inflammatory responses to reduce interleukin 6 (IL-6) levels, and NF-κB nuclear translocation. These findings suggest that LM hydrolysates could potentially offer hepatoprotective effects by mitigating the inflammatory responses induced by LPS/D-Gal.
A computational two-scale approach to cancellous bone remodelling
Authors: Steinmann Paul , Schmidt Ina , Pivonka Peter , Papastavrou Areti 
Published: May 2024

AbstractWe propose a novel two-scale (meso-macro-scale) approach to computationally capture cancellous bone remodelling allowing for efficient and effective numerical implementation. Therein, the macro-scale is governed by the well-established kinematics and kinetics of one-scale continuum bone remodelling. However, the constitutive behaviour is not postulated phenomenologically at the macro-scale, but rather follows from the meso-scale. There, for the sake of computational efficiency, the trabecular architecture is idealised as a truss network with the cross-sectional area of the trabeculae adapting to mechanical loading. Then, the meso- and the macro-scale are coupled through up- and down-scaling. Computational results on benchmark problems from bio-mechanics demonstrate that the proposed two-scale approach is effective from a modelling perspective and efficient from a computational perspective. In particular, it automatically captures anisotropy resulting from the irregular trabecular architecture at the meso-scale, and, most importantly, enables the direct investigation of different trabecular structures at the meso-scale, thereby serving as a virtual “magnifiying glass”. As an outlook, the proposed two-scale approach to cancellous bone remodelling provides an excellent launch pad for further extension, e.g., by considering more complex trabecular architectures and/or through inclusion of micro-scale bone cellular activities.
Co-created augmented reality app and its impact on the effectiveness of learning a foreign language and on cultural knowledge
Authors: Di Fuccio Raffaele , Kic-Drgas Joanna , Woźniak Joanna 
Published: May 2024

AbstractThis paper addresses the limited exploration of the impact of virtual and augmented reality on the learning process, particularly within the context of foreign language learning among young learners. Motivated by this research gap, the EULALIA, conducted from 2019 to 2023 (2019-1-IT02-KA203-063228), sought to evaluate the efficacy of integrating technology in language education. Specifically, the study investigates the influence of virtual and augmented reality on foreign language learning, examining its effects on subjectively assessed cultural knowledge, and workflow during classes, as perceived by educators. Involving 239 learners, the study employed a pre/post survey methodology, wherein participants provided feedback before and after working with the EULALIA application or traditional learning methods. The quantitative analysis of survey data was complemented by semi-structured interviews with participating teachers, providing additional insights. The results indicate a statistically significant increase in cultural knowledge among the group utilizing augmented reality. The findings suggest a positive impact on students’ learning progression, and workflow during classes. This research contributes valuable insights into the potential of integrating virtual and augmented reality in language education, offering a foundation for future pedagogical advancements.
Google Gemini as a next generation AI educational tool: a review of emerging educational technology
Authors: Imran Muhammad , Almusharraf Norah 
Published: May 2024

AbstractThis emerging technology report discusses Google Gemini as a multimodal generative AI tool and presents its revolutionary potential for future educational technology. It introduces Gemini and its features, including versatility in processing data from text, image, audio, and video inputs and generating diverse content types. This study discusses recent empirical studies, technology in practice, and the relationship between Gemini technology and the educational landscape. This report further explores Gemini’s relevance for future educational endeavors and practical applications in emerging technologies. Also, it discusses the significant challenges and ethical considerations that must be addressed to ensure its responsible and effective integration into the educational landscape.
Holocene loess in the Himalayas piedmont of southeastern Nepal
Authors: Latrubesse Edgardo M. , Nugraha Abang M. S. 
Published: May 2024

AbstractLoess, loess-like, sandy loess, and sandy-silty fluvial–aeolian deposits are intercalated to fluvial sediments and lie on a flat surface under intense agricultural land use in Bardibas, Mahottari district, central Nepal. To identify the depositional processes and provenance, we carried out geochemical, mineralogical, SEM, and grain-size analyses. Optically stimulated luminescence (OSL) dating shows the aeolian deposits are from the late Holocene (1.0–4.8 ka). Our results demonstrate that the loess and loess-like deposits (i) were dominantly sourced locally from deflation Quaternary sediments of the Terai Plain; (ii) are related to the composition of Siwalik rocks; and (iii) were deposited during dry periods of weak activity of the Indian Summer Monsoon.
Whole-cell one-pot biosynthesis of dodecanedioic acid from renewable linoleic acid
Authors: Qi Yi-Ke , Pan Jiang , Zhang Zhi-Jun , Xu Jian-He 
Published: May 2024

Abstract
Background
Dodecanedioic acid (DDA), a typical medium-chain dicarboxylic fatty acid with widespread applications, has a great synthetic value and a huge industrial market demand. Currently, a sustainable, eco-friendly and efficient process is desired for dodecanedioic acid production.

Results
Herein, a multi-enzymatic cascade was designed and constructed for the production of DDA from linoleic acid based on the lipoxygenase pathway in plants. The cascade is composed of lipoxygenase, hydroperoxide lyase, aldehyde dehydrogenase, and unidentified double-bond reductase in E. coli for the main cascade reactions, as well as NADH oxidase for cofactor recycling. The four component enzymes involved in the cascade were co-expressed in E. coli, together with the endogenous double-bond reductase of E. coli. After optimizing the reaction conditions of the rate-limiting step, 43.8 g L− 1 d− 1 of DDA was obtained by a whole-cell one-pot process starting from renewable linoleic acid.

Conclusions
Through engineering of the reaction system and co-expressing the component enzymes, a sustainable and eco-friendly DDA biosynthesis route was set up in E. coli, which afforded the highest space time yield for DDA production among the current artificial multi-enzymatic routes derived from the LOX-pathway, and the productivity achieved here ranks the second highest among the current research progress in DDA biosynthesis.

Graphical Abstract
The Effect of Cannabidiol on Subjective Responses to Endurance Exercise: A Randomised Controlled Trial
Authors: McCartney Danielle , Irwin Christopher , Bawa Zeeta , Palmer Blake , Sahinovic Ayshe , Delang Nathan , Cox Gregory R. , Desbrow Ben , Lau Namson S. , McGregor Iain S. 
Published: May 2024

Abstract
Background
Exercise is known to improve health. However, it can be unpleasant, often inducing negative feelings, or ‘affect’. Cannabidiol (CBD), a non-intoxicating constituent of the cannabis plant, has been reported to enhance the subjective experience of exercise; specifically, in trained individuals performing fixed-intensity endurance activity. Here, we investigated the effects of CBD on subjective responses to exercise under more ecologically valid conditions; namely, in recreationally active individuals performing self-paced endurance activity.

Methods
A randomised, double-blind, placebo-controlled, crossover trial was conducted at Griffith University between July 17 and August 28, 2023. Griffith University students studying sports nutrition were invited to take part, with eligible volunteers ≥ 18 years of age and able to perform endurance exercise. Participants ingested placebo or 150 mg CBD in two soft-gel capsules 90 min before completing a self-paced 25-lap (10 km) run around an outdoor athletics track (400 m, synthetic). The primary outcomes were affective valence during exercise, assessed on completion of laps 6, 12, 18 and 24 using the ‘Feelings Scale’, and positive and negative affect, assessed at baseline, pre-run and post-run using the ‘Positive and Negative Affect Schedule’. Exercise enjoyment, motivation and self-efficacy, the core features of the ‘runner’s high’ (i.e., euphoria, pain, anxiety, sedation), perceived exertion and run time were also assessed.

Results
Fifty-two participants were randomised and 51 were included in the final sample (n = 22 female; 22 [21–25] years). Exercise induced negative affect (i.e., at the time of undertaking) and increased pain. CBD did not counteract either response. In fact, CBD had no significant effects on any of the outcomes measured. In contrast, exercise, once completed, increased positive affect, and decreased negative affect and anxiety.

Conclusions
CBD (150 mg, oral) does not appear to enhance the subjective experience of self-paced endurance exercise in recreationally active individuals. Nor, however, does it appear to compromise it. These findings suggest that CBD use is safe under exercise conditions and unlikely to impede physical activity participation. Our study also reaffirms the powerful mood-enhancing effects of exercise.

Trial Registration
Registered with the Australian New Zealand Clinical Trials Registry (www.anzctr.org.au) on May 31, 2023 (Trial ID: ACTRN12623000593639).
Navigating bioenergy horizons: a critical examination of Europe’s potential, with Belgium as a case study
Authors: Colla Martin , Verleysen Kevin , Blondeau Julien , Jeanmart Hervé 
Published: May 2024

AbstractEstimates of the energy potential of the different energy sources are essential for modelling energy systems. However, the potential of biomass is debatable due to the numerous dimensions and assumptions embedded. It is thus important to investigate further the final potential to understand their implications. Therefore, this study analyses European studies assessing biomass potential and proposes a critical discussion on the different results to converge to a realistic range of potentials for 2030. Biomass is divided into four categories: forestry products, agricultural residues, energy crops and other waste, each with sub-categories. Belgium is used as a case study to highlight the convergences and divergences of the studies. Having a national case study allows for more precise analyses through in-depth comparisons with national data and reports. The potential estimates are compared with the current production for each category in order to have a better view of the gap to be bridged. From these national perspectives, the European potential can be better apprehended. The results show that the realistic potentials for 2030 for Belgium and Europe are somewhat in the lower range of the estimates of the different studies: from 30 to 41 TWh and from 2000 to 2500 TWh, respectively. The forestry biomass is already well exploited with a slight potential increase, while the agricultural residues present the most significant potential increase. The realistic potential for energy crops in Belgium turned out to be close to the minimum estimates. Indeed, the implications of those crops are considerable regarding the agricultural structure and logistics. This article emphasises that no energy potential is neutral, as it involves a specific system in terms of agriculture, forestry or waste management, with broader social, economic or environmental implications. Consequently, using one estimate rather than another is not a trivial matter; it has an impact on the system being modelled from the outset.
Pooled prevalence and associated factors of teenage pregnancy among women aged 15 to 19 years in sub-Saharan Africa: evidence from 2019 to 2022 demographic and health survey data
Authors: Mekonen Enyew Getaneh 
Published: May 2024

Abstract
Background
Teenage pregnancy is becoming one of the most common social and public health problems worldwide, with the highest prevalence in sub-Saharan Africa. Health risks and adverse outcomes of pregnancy and childbirth among adolescent girls are the commonest cause of the global burden of maternal morbidity and mortality. This study is intended to determine the pooled prevalence and determinants of teenage pregnancy in sub-Saharan Africa using the most recent demographic and health survey data (2019–2022).

Methods
A cross-sectional study was conducted using data from the most recent demographic and health surveys of four countries (Kenya, Tanzania, Gabon, and Cameroon) in sub-Saharan Africa conducted between 2019 and 2022. A total weighted sample of 12,829 teenagers aged 15 to 19 years was included in the study. Data extracted from demographic and health survey data sets were cleaned, recorded, and analyzed using STATA/SE version 14.0 statistical software. Multilevel mixed-effects logistic regression was used to determine the factors associated with the dependent variable. Finally, variables with a p-value ≤ 0.05 and an adjusted odds ratio with a 95% confidence interval were declared statistically significant.

Results
The pooled prevalence of teenage pregnancy among women aged 15 to 19 years was 18.15% (95% CI: 17.49, 18.83). Teenage pregnancy was positively associated with the respondent’s age [AOR = 2.97; 95% CI (2.55, 3.46)], educational status [AOR = 2.21; 95% CI (1.62, 3.03)] and [AOR = 1.80; 95% CI (1.54, 2.12)], wealth status [AOR = 2.61; 95% CI (2.12, 3.22)] and [AOR = 1.65; 95% CI (1.33, 2.05)], relation to the household head [AOR = 2.09; 95% CI (1.60, 2.72)], and unmet need for contraception [AOR = 14.3; 95% CI (11.5, 17.8)]. On the other hand, it was negatively associated with marital status [AOR = 0.08; 95% (0.07, 0.10)], working status [AOR = 0.75; 95% CI (0.64, 0.88)], age at first sex [AOR = 0.68; 95% CI (0.58, 0.80)], contraceptive use [AOR = 0.25; 95% CI (0.20, 0.30)], contraceptive knowledge [AOR = 0.27; 95% CI (0.19, 0.40)], and community contraceptive utilization [AOR = 0.85; 95% CI (0.73, 0.99)].

Conclusion
In the current study, one out of six young women aged 15 to 19 experienced teenage pregnancy. Therefore, addressing unmet needs for family planning, improving women’s educational status, and giving special attention to teenagers with low educational and economic status are recommended.
Plasma CD24 level as a promising prognostic biomarker of hepatocellular carcinoma
Authors: Rasmy Hany Samir , Awad Emad Ahmad , Mohamed Eslam Safwat , Boshra Amal Samy , Ibrahim Shereen Abdel Monem , Isaac Amira 
Published: May 2024

Abstract
Background
Hepatocellular carcinoma constitutes the most common primary hepatic cancer and remains a major medical burden in both developing and developed world. It ranks fifth in terms of global cases and second in terms of deaths for males.CD24 is known as a heavily glycosylated cell surface molecule that is highly expressed in a wide variety of human malignancies. It plays an important role in self-renewal, proliferation, migration, invasion, and drug resistance. The aim of this work was to evaluate the potential role of serum CD24 in the diagnosis and prediction of response to interventional therapy among hepatocellular carcinomas.

Methods
This study included 40 adult Egyptian patients who had liver cirrhosis and hepatocellular carcinoma (HCC group). Another group of 20 patients with liver cirrhosis only served as controls (Cirrhosis group). All patients underwent standard laboratory tests and abdominal ultrasound. For HCC patients, a triphasic CT scan, alpha-fetoprotein was done. CD24 levels were measured in all patients, and in HCC patients at baseline and one month after intervention.

Results
Baseline CD24 was significantly higher among HCC group in comparison to cirrhosis group (19.463 ± 8.573 vs. 0.725 ± 0.125 mg/L) with an overall p value < 0.001. Serum CD24 levels significantly declined after locoregional treatment from 19.463 ± 8.573 mg/L to 3.569 ± 1.248 mg/L (p < 0.001). Baseline CD24 was a useful marker in eligibility for HCC intervention with 80% sensitivity and 74.29% specificity at a cutoff of ≤ 23 mg/L, and it also had 62.96% sensitivity and 100% specificity in prediction of cure after locoregional treatment at a cutoff of ≤ 19.5 mg/L.

Conclusion
CD24 could be a helpful diagnostic and prognostic marker for HCC, as its baseline level is useful in predicting both eligibility for intervention and cure after locoregional treatment.
An ecological view on the correlates of sedentary behavior in Brazilian adolescents: a cross-sectional study with network analysis
Authors: Ywgne José , Luz Leonardo G. O. , Thuany Mabliny , Lima Cayo , Araujo Raphael , Silva Ellen , Magalhães Kleberton , Bandeira Paulo , Silva Danilo R. 
Published: May 2024

Abstract
Background
Sedentary behavior has been identified as a public health concern. The present study analyzed the correlates of sedentary behavior in Brazilian adolescents through network analysis, in the light of an ecological approach.

Methods
The sample consisted of 126,354 adolescents, participating in the fourth edition of the Brazilian National School Health Survey. The variables were grouped into domains, namely intrapersonal, interpersonal, perceived environment, school variables, food variables, active behavior domains, and leisure sedentary behavior. The data were analyzed using network analysis.

Results
The results reinforce that sedentary behavior is independent of the assessed active behavior domains, despite being weakly related to physical activity outside physical education classes (− 0.073). The variable with the greatest closeness and one of the variables with the greatest expected influence in the model was having internet at home, which was associated with private schools (− 0.230), having a cell phone (0.378), having a computer or notebook at home (0.409), and a greater weekly frequency of watching television (0.169). Furthermore, having internet at home was strongly associated with an increase in sedentary behavior (− 0.197), which, in turn, was linked to greater consumption of treats (0.067) and sodas (0.052).

Conclusions
We concluded that having internet at home is associated with longer sedentary time, which, in turn, is associated with greater consumption of foods of poorer nutritional quality. Interventions on sedentary behavior should be specific for population subgroups and consider actions in different levels.
Unification of Efforts to Improve Global Access to Cancer Therapeutics: Report From the 2022/2023 Access to Essential Cancer Medicines Stakeholder Summit
Authors: Briercheck Edward , Pyle Doug , Adams Cary , Atun Rifat , Booth Christopher , Dent Jennifer , Garcia-Gonzalez Pat , Ilbawi Andre , Jazieh Abdul Rahman , Kerr David , Knaul Felicia , Kobayashi Emily , Lim Christopher , Maza Maurizio , Milner Danny , Navarro Maria Fernanda , O'Brien Meg , Rodriguez-Galindo Carlos , Sullivan Richard , Torode Julie , Vokes Everett , Gralow Julie 
Published: May 2024

PURPOSE There is an urgent need to improve access to cancer therapy globally. Several independent initiatives have been undertaken to improve access to cancer medicines, and additional new initiatives are in development. Improved sharing of experiences and increased collaboration are needed to achieve substantial improvements in global access to essential oncology medicines. METHODS The inaugural Access to Essential Cancer Medicines Stakeholder Meeting was organized by ASCO and convened at the June 2022 ASCO Annual Meeting in Chicago, IL, with two subsequent meetings, Union for International Cancer Control World Cancer Congress held in Geneva, Switzerland, in October 2022 and at the ASCO Annual Meeting in June of 2023. Invited stakeholders included representatives from cancer institutes, physicians, researchers, professional societies, the pharmaceutical industry, patient advocacy organizations, funders, cancer organizations and foundations, policy makers, and regulatory bodies. The session was moderated by ASCO. Past efforts and current and upcoming initiatives were initially discussed (2022), updates on progress were provided (2023), and broad agreement on resulting action steps was achieved with participants. RESULTS Summit participants recognized that while much work was ongoing to enhance access to cancer therapeutics globally, communication and synergy across projects and organizations could be enhanced by providing a platform for collaboration and shared expertise. CONCLUSION The summit resulted in new cross-stakeholder insights and planned collaboration addressing barriers to accessing cancer medications. Specific actions and timelines for implementation and reporting were established.