bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of residual sodium carbonate (RSC) and sodium adsorption ratio (SAR) in fresh water and laundry grey water for irrigation usage
Authors: Khapra Rajat , Singh Nirankar 
Published: May 2024

AbstractThe current study was carried out to assess the suitability of laundry grey water (LGW) for reuse in irrigation so that it can help in the reduction of freshwater stress in irrigation sector. To address this objective, concentration of sodium (Na+), calcium (Ca2+), magnesium (Mg2+), carbonate (CO32−), bicarbonate (HCO3−), and phosphate (PO43−) were tested in fresh water (FW) collected before laundry washing and LGW generated after laundry washing from different households. The suitability of LGW for irrigation purpose was determined by using water quality indices such as Sodium adsorption ratio (SAR) and Residual Sodium Carbonate (RSC). The SAR values of FW at the rural and urban area sites varied from 0.84 to 1.10 and 0.82 to 4.30 respectively and remained in the excellent category for irrigation purpose. The SAR values of LGW at the rural and urban sites varied from 10.06 to 13.01 and 6.26 to 9.68, respectively. In contrast to the SAR values of the LGW at rural site, which remained under good quality category, SAR values remained under excellent category for irrigation purpose at urban sites. RSC values of FW and LGW were below 3.97 showing low or medium hazards associated with it for irrigation.
Analysis of tofacitinib safety in ulcerative colitis from the completed global clinical developmental program up to 9.2 years of drug exposure
Authors: Panés Julian , D’Haens Geert R. , Sands Bruce E. , Ng Siew C. , Lawendy Nervin , Kulisek Nicole , Guo Xiang , Wu Joseph , Vranic Ivana , Panaccione Remo , Vermeire Séverine 
Published: May 2024

AbstractBackground and AimsTofacitinib is an oral Janus kinase inhibitor for the treatment of ulcerative colitis (UC). We report an integrated summary of tofacitinib safety from the completed global UC clinical program (9.2 years maximum tofacitinib exposure).MethodsThis analysis included patients receiving tofacitinib 5 or 10 mg twice daily (b.i.d.) from completed phase 2/3 placebo‐controlled studies, an open‐label, long‐term extension study and a randomized phase 3b/4 study. Proportions and incidence rates (IRs; unique patients with events/100 patient‐years [PY] of exposure) were evaluated for deaths and adverse events (AEs) of special interest (AESI).ResultsOverall, 1157 patients received ≥1 dose of tofacitinib 5 or 10 mg b.i.d.; 938 (81.1%) were in the predominant dose tofacitinib 10 mg b.i.d. group; 552 (47.7%) received tofacitinib for ≥2 years; total exposure: 3202.0 PY; 994 (85.9%) experienced AEs; 254 (22.0%) experienced serious AEs. Median treatment duration: 1.7 (range 0.0–9.2) years. IRs (95% CI) for combined tofacitinib doses: deaths 0.24 (0.10–0.48); serious infections (SIs) 1.80 (1.37–2.32); herpes zoster (HZ; non‐serious and serious) 3.24 (2.63–3.94); serious HZ 0.24 (0.10–0.48); opportunistic infections 0.96 (0.65–1.36); malignancies (excluding non‐melanoma skin cancer [NMSC]) 0.88 (0.59–1.26); NMSC 0.71 (0.45–1.07); major adverse cardiovascular events 0.27 (0.12–0.52); deep vein thrombosis 0.06 (0.01–0.22); pulmonary embolism 0.18 (0.07–0.40); and gastrointestinal perforations 0.09 (0.02–0.27).ConclusionsExcept for HZ and SIs, IRs for AESI were <1 case/100 PY. Safety was consistent with previous analyses of shorter exposure and tofacitinib's known safety profile, including real‐world data.ClinicalTrials.govNCT00787202; NCT01465763; NCT01458951; NCT01458574; NCT01470612; NCT03281304.
Water scarcity in the fast‐growing megacity of Lagos, Nigeria and opportunities for managed aquifer recharge
Authors: Olabode Oluwaseun Franklin , Comte Jean‐Christophe 
Published: May 2024

AbstractIn the last three decades, the world has experienced a rapid emergence of megacities. The increasing demographics, urbanization, and water demand brought severe and undesired effects on the quantity and quality of their water resources. A prime example is Lagos (Nigeria, West Africa), which is projected to become the world's largest city by 2100, and faces water scarcity challenges common to other megacities of developing countries. A literature review reveals the vast gap between water demand and regulated supply, inadequate knowledge and information on the current state of water (re)sources, and major, yet unregulated, use of groundwater. It further highlights the impacts of uncontrolled wastewater discharge into surface waters and aquifers, the role of increasing paved surfaces and blocked drainages on flooding, the inadequate supply of potable water, and the unsustainable abstraction of groundwater. Here, we examine the potential of managed aquifer recharge (MAR) to address these recurrent challenges across the megacity. The analysis reveals the opportunities and potential risks associated with the capture of wastewater, storm water, and brackish surface water for MAR. These waters, after appropriate treatment and subsurface storage may bridge the growing water supply–demand gap and mitigate the effects of groundwater (over)exploitation, including aquifer depletion, saltwater intrusion and land subsidence. Immediate efforts should focus on improving the conceptual and quantitative knowledge of Lagos' hydrogeology and groundwater resources through comprehensive spatial–temporal groundwater monitoring and socio‐economic studies of groundwater access and use. The insights provided may inform other fast‐growing coastal megacities in Africa and the wider developing world.This article is categorized under:
Science of Water > Water and Environmental Change
Engineering Water > Water, Health, and Sanitation
Human Water > Value of Water
Science of Water > Hydrological Processes
Grid Search Optimization of Novel SNN-ESN Classifier on a Supercomputer Platform
Authors: Penkov Dimitar , Koprinkova-Hristova Petia , Kasabov Nikola , Nedelcheva Simona , Ivanovska Sofiya , Yordanov Svetlozar 
Published: May 2024

AbstractThis work is demonstrating the use of a supercomputer platform to optimise hyper-parameters of a proposed by the team novel SNN-ESN computational model, that combines a brain template of spiking neurons in a spiking neural network (SNN) for feature extraction and an Echo State Network (ESN) for dynamic data series classification. A case study problem and data are used to illustrate the functionalities of the SNN-ESN. The overall SNN-ESN classifier has several hyper-parameters that are subject to refinement, such as: spiking threshold, duration of the refractory period and STDP learning rate for the SNN part; reservoir size, spectral radius of the connectivity matrix and leaking rate for the ESN part. In order to find the optimal hyper-parameter values exhaustive search over all possible combinations within reasonable intervals was performed using supercomputer Avitohol. The resulted optimal parameters led to improved classification accuracy. This work demonstrates the importance of model parameter optimisation using a supercomputer platform, which improves the usability of the proposed SNN-ESN for real-time applications on complex spatio-temporal data.
Ethical Judgment of What (Not) to Be Disclosed
Authors: Ghaly Mohammed 
Published: May 2024

AbstractChapter three provides an in-depth ethical analysis of what types of incidental findings (IFs) from genomic research or clinical testing should or should not be disclosed to individuals. It begins by providing a lucid definition of IFs and delineating the scope under consideration. The chapter then examines two categories where disclosure is judged as obligatory: firstly, informing potential recipients about the likelihood of IFs arising, and secondly, disclosing life-saving IFs associated with actionable genetic conditions. A key focus is the controversial issue of misattributed paternity IFs, which reveal that the assumed father is not the biological father. Two contrasting perspectives are presented: one prohibiting disclosure to the assumed father based on Islamic jurisprudential principles and societal ethical concerns, while another minority viewpoint asserts the obligation to disclose, with supporting arguments outlined, and accompanied with critical commentary. Subsequently, the chapter goes on to analyze IFs recommended (praiseworthy but not obligatory) for disclosure, employing the theoretical framing of the Islamic ethical concepts around seeking/providing medical care, with the American College of Medical Genetics (ACMG) list serving as an applied example. Additionally, a category of IFs judged as reprehensible (blameworthy but not prohibited) to disclose is examined through the lens of distant lineage and demonstrated through the applied case of genetic ancestry findings.
Subsystem complexity and measurements in holography
Authors: Jian Shao-Kai , Zhang Yuzhen 
Published: May 2024

Abstract
We investigate the impact of measuring one subsystem on the holographic complexity of another. While a naive expectation might suggest a reduction in complexity due to the collapse of the state to a trivial product state during quantum measurements, our findings reveal a counterintuitive result: in numerous scenarios, measurements on one subsystem can amplify the complexity of another. We first present a counting argument elucidating this complexity transition in random states. Then, employing the subregion “complexity=volume” (CV) proposal, we identify a complexity phase transition induced by projective measurements in various holographic CFT setups, including CFT vacuum states, thermofield double states, and the joint system of a black hole coupled to a bath. According to the AdS/BCFT correspondence, the post-measurement dual geometry involves an end-of-the-world brane created by the projective measurement. The complexity phase transition corresponds to the transition of the entanglement wedge to the one connected to the brane. In the context of the thermofield double setup, complete projection on one side can transform the other side into a boundary state black hole with higher complexity or a pure AdS with lower complexity. In the joint system of a black hole coupled to a nongraviting bath, where (a part of) the radiation is measured, the BCFT features two boundaries: one for the black hole and the other for the measurement. We construct the bulk dual involving intersecting or non-intersecting branes, and investigate the complexity transition induced by the projective measurement. Notably, for a subsystem that contains the black hole brane, its RT surface may undergo a transition, giving rise to a complexity jump.
Semi-chiral operators in 4d $$ \mathcal{N} $$ = 1 gauge theories
Authors: Budzik Kasia , Gaiotto Davide , Kulp Justin , Williams Brian R. , Wu Jingxiang , Yu Matthew 
Published: May 2024

Abstract
We discuss the properties of quarter-BPS local operators in four-dimensional $$ \mathcal{N} $$
N
= 1 supersymmetric Yang-Mills theory using the formalism of holomorphic twists. We study loop corrections both to the space of local operators and to algebraic operations which endow the twisted theory with an infinite symmetry algebra. We classify all single-trace quarter-BPS operators in the planar approximation for SU(N) gauge theory and propose a holographic dual description for the twisted theory. We classify perturbative quarter-BPS operators in SU(2) and SU(3) gauge theories with sufficiently small quantum numbers and discuss possible non-perturbative corrections to the answer. We set up analogous calculations for some theories with matter.
Counting atypical black hole microstates from entanglement wedges
Authors: Wei Zixia , Yoneta Yasushi 
Published: May 2024

Abstract
Disentangled black hole microstates are atypical states in holographic CFTs whose gravity duals do not have smooth horizons. If there exist sufficiently many disentangled microstates to account for the entire black hole entropy, then any black hole microstate can be written as a superposition of states without smooth horizons. We show that there exist sufficiently many disentangled microstates to account for almost the entire black hole entropy of a large AdS black hole at the semiclassical limit GN → 0. In addition, we also argue that in generic quantum many-body systems with short-ranged interactions, there exist sufficiently many area law states in the microcanonical subspace to account for almost the entire thermodynamic entropy in the standard thermodynamic limit. Area law states are atypical since a typical state should contain volume law entanglement. Furthermore, we also present an explicit way to construct such a set of area law states, and argue that the same construction may also be used to construct disentangled states.
Holographic torus correlators in AdS3 gravity coupled to scalar field
Authors: He Song , Li Yun-Ze , Zhang Yunda 
Published: May 2024

Abstract
This paper investigates holographic torus correlators of generic operators at conformal infinity and a finite cutoff within AdS3 gravity coupled with a free scalar field. Using a near-boundary analysis and solving the gravitational boundary value problem, we solve Einstein’s equation and calculate mixed correlators for massless and massive coupled scalar fields. The conformal Ward identity on the torus has been reproduced holographically, which can be regarded as a consistency check. Further, recurrence relations for a specific class of higher-point correlators are derived, validating AdS3/CFT2 with non-trivial boundary topology. While the two-point scalar correlator is accurately computed on the thermal AdS3 saddle, the higher-point correlators associated with scalar and stress tensor operators are explored.
Advanced tools for basis decompositions of genus-one string integrals
Authors: Zhang Yong 
Published: May 2024

Abstract
In string theories, one-loop scattering amplitudes are characterized by integrals over genus-one surfaces using the Kronecker-Eisenstein series. A recent methodology proposed a genus-one basis formed from products of these series of chain topologies. A prior work further deconstructed cyclic products of the Kronecker-Eisenstein series on this basis. Building on it, our study further employs advanced and comprehensive combinatorial techniques to decompose more general genus-one integrands including a product of an arbitrary number of cyclic products of Kronecker-Eisenstein series, supplemented by Mathematica codes. Our insights enhance the understanding of multiparticle amplitudes across various string theories and illuminate loop-level parallels with string tree-level amplitudes.
Magnetic charges for the graviton
Authors: Hull C. M. 
Published: May 2024

Abstract
Symmetries and conserved charges are investigated for linearised gravity and its dual formulation in terms of the dual graviton field. Conserved charges are constructed for the dual graviton theory that are associated with invariances of the dual graviton theory. These invariances arise for gauge parameters that are certain generalised Killing tensors. These electric-type charges for the dual graviton are then shown to give magnetic-type charges for the graviton. One of the magnetic-type gravitational charges obtained in this way is the linearisation of the gravitational charge in d ≥ 5 dimensions that arises as a central charge in the supersymmetry algebra and is carried by Kaluza-Klein monopoles. Solutions of linearised gravity carrying the magnetic gravitational charges are discussed. The application of the approach used here to other gauge theories is discussed.
Usp14 deficiency removes α-synuclein by regulating S100A8/A9 in Parkinson’s disease
Authors: Ding Liuyan , Lu Lin , Zheng Shaohui , Zhang Zhiling , Huang Xingting , Ma Runfang , Zhang Mengran , Xu Zongtang , Chen Minshan , Guo Zhimei , Zhu Si , Gong Junwei , Mao Hengxu , Zhang Wenlong , Xu Pingyi 
Published: May 2024

AbstractUbiquitin-proteasome system dysfunction triggers α-synuclein aggregation, a hallmark of neurodegenerative diseases, such as Parkinson’s disease (PD). However, the crosstalk between deubiquitinating enzyme (DUBs) and α-synuclein pathology remains unclear. In this study, we observed a decrease in the level of ubiquitin-specific protease 14 (USP14), a DUB, in the cerebrospinal fluid (CSF) of PD patients, particularly females. Moreover, CSF USP14 exhibited a dual correlation with α-synuclein in male and female PD patients. To investigate the impact of USP14 deficiency, we crossed USP14 heterozygous mouse (USP14+/−) with transgenic A53T PD mouse (A53T-Tg) or injected adeno-associated virus (AAV) carrying human α-synuclein (AAV-hα-Syn) in USP14+/− mice. We found that Usp14 deficiency improved the behavioral abnormities and pathological α-synuclein deposition in female A53T-Tg or AAV-hα-Syn mice. Additionally, Usp14 inactivation attenuates the pro-inflammatory response in female AAV-hα-Syn mice, whereas Usp14 inactivation demonstrated opposite effects in male AAV-hα-Syn mice. Mechanistically, the heterodimeric protein S100A8/A9 may be the downstream target of Usp14 deficiency in female mouse models of α-synucleinopathies. Furthermore, upregulated S100A8/A9 was responsible for α-synuclein degradation by autophagy and the suppression of the pro-inflammatory response in microglia after Usp14 knockdown. Consequently, our study suggests that USP14 could serve as a novel therapeutic target in PD.
The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization
Authors: Gao Bin , Zhu Shunyi 
Published: May 2024

AbstractInsect host defense comprises two complementary dimensions, microbial killing-mediated resistance and microbial toxin neutralization-mediated resilience, both jointly providing protection against pathogen infections. Insect defensins are a class of effectors of innate immunity primarily responsible for resistance to Gram-positive bacteria. Here, we report a newly originated gene from an ancestral defensin via genetic deletion following gene duplication in Drosophila virilis, which confers an enhanced resilience to Gram-positive bacterial infection. This gene encodes an 18-mer arginine-rich peptide (termed DvirARP) with differences from its parent gene in its pattern of expression, structure and function. DvirARP specifically expresses in D. virilis female adults with a constitutive manner. It adopts a novel fold with a 310 helix and a two CXC motif-containing loop stabilized by two disulfide bridges. DvirARP exhibits no activity on the majority of microorganisms tested and only a weak activity against two Gram-positive bacteria. DvirARP knockout flies are viable and have no obvious defect in reproductivity but they are more susceptible to the DvirARP-resistant Staphylococcus aureus infection than the wild type files, which can be attributable to its ability in neutralization of the S. aureus secreted toxins. Phylogenetic distribution analysis reveals that DvirARP is restrictedly present in the Drosophila subgenus, but independent deletion variations also occur in defensins from the Sophophora subgenus, in support of the evolvability of this class of immune effectors. Our work illustrates for the first time how a duplicate resistance-mediated gene evolves an ability to increase the resilience of a subset of Drosophila species against bacterial infection.
Sphingosine is involved in PAPTP-induced death of pancreas cancer cells by interfering with mitochondrial functions
Authors: Patel Sameer H. , Wilson Gregory C. , Wu Yuqing , Keitsch Simone , Wilker Barbara , Mattarei Andrea , Ahmad Syed A. , Szabo Ildiko , Gulbins Erich 
Published: May 2024

Abstract
Pancreas ductal adenocarcinoma belongs to the most common cancers, but also to the tumors with the poorest prognosis. Here, we pharmacologically targeted a mitochondrial potassium channel, namely mitochondrial Kv1.3, and investigated the role of sphingolipids and mutated Kirsten Rat Sarcoma Virus (KRAS) in Kv1.3-mediated cell death. We demonstrate that inhibition of Kv1.3 using the Kv1.3-inhibitor PAPTP results in an increase of sphingosine and superoxide in membranes and/or membranes associated with mitochondria, which is enhanced by KRAS mutation. The effect of PAPTP on sphingosine and mitochondrial superoxide formation as well as cell death is prevented by sh-RNA-mediated downregulation of Kv1.3. Induction of sphingosine in human pancreas cancer cells by PAPTP is mediated by activation of sphingosine-1-phosphate phosphatase and prevented by an inhibitor of sphingosine-1-phosphate phosphatase. A rapid depolarization of isolated mitochondria is triggered by binding of sphingosine to cardiolipin, which is neutralized by addition of exogenous cardiolipin. The significance of these findings is indicated by treatment of mutated KRAS-harboring metastasized pancreas cancer with PAPTP in combination with ABC294640, a blocker of sphingosine kinases. This treatment results in increased formation of sphingosine and death of pancreas cancer cells in vitro and, most importantly, prolongs in vivo survival of mice challenged with metastatic pancreas cancer.

Key messages

Pancreatic ductal adenocarcinoma (PDAC) is a common tumor with poor prognosis.

The mitochondrial Kv1.3 ion channel blocker induced mitochondrial sphingosine.

Sphingosine binds to cardiolipin thereby mediating mitochondrial depolarization.

Sphingosine is formed by a PAPTP-mediated activation of S1P-Phosphatase.

Inhibition of sphingosine-consumption amplifies PAPTP effects on PDAC in vivo.
Polyandry may mitigate the negative impact of reproductive interference among bumblebees in Japan
Authors: Inokuchi Fumina , Inoue Maki N. , Kanbe Yuya , Ito Masaaki , Takahashi Jun-ichi , Nomura Tetsuro , Goka Koichi , Tsuchida Koji 
Published: May 2024

AbstractIn social hymenopterans, monandry of the queen is an ancestral trait, and polyandry is a derived trait. Polyandry of the queen is the norm in a limited number of lineages, such as honeybees, leaf-cutting ants, Pogonomyrmex ants, and Vespula wasps, which presumably provide fitness advantages for the whole colony. The queen of the introduced bumblebee, Bombus terrestris, is polyandrous in Japan, whereas it is monandrous in native regions. We hypothesize that polyandry can evolve in a process that avoids the negative impacts of reproductive interference caused by interspecific mating and conducted genetic studies of the invasive species B. terrestris and two native subspecies, Bombus hypocrita sapporoensis and Bombus hypocrita hypocrita, in Japan. Our results revealed that although the native queens of B. hypocrita hypocrita allopatric with B. terrestris were strictly monandrous, the native queens of B. hypocrita sapporoensis sympatric with B. terrestris were polyandrous. These results suggested that the queens of native B. hypocrita sapporoensis do not experience negative impacts on interspecific mating from the invasive B. terrestris. We discuss the possibility that reproductive interference is a driving force in selection for multiple mating through an arms race between sympatric species.