bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffuse-interface approximation and weak–strong uniqueness of anisotropic mean curvature flow
Authors: Laux Tim , Stinson Kerrek , Ullrich Clemens 
Published: May 2024

AbstractThe purpose of this paper is to derive anisotropic mean curvature flow as the limit of the anisotropic Allen–Cahn equation. We rely on distributional solution concepts for both the diffuse and sharp interface models and prove convergence using relative entropy methods, which have recently proven to be a powerful tool in interface evolution problems. With the same relative entropy, we prove a weak–strong uniqueness result, which relies on the construction of gradient flow calibrations for our anisotropic energy functionals.
Darker Legacies Of Anti-corruption: Fascist Criticisms of the Law in Inter-war Romania
Authors: Cercel Cosmin 
Published: May 2024

AbstractThe aim of this article is to open a new way of understanding corruption by examining its place within the law and culture of the European semi-periphery, with a focus on inter-war Romania. My intention is to operate a twofold displacement of the analysis of the anti-corruption and the status of constitutional practice in this context. First, I aim to reposition the question of political corruption within a jurisprudential and legal historical context. In this way I inquire what is the legal theoretical importance of political corruption in a post-dependency context? In other words, what can the representation of corruption entail for law, and for a particular legal historical trajectory within the European periphery. Second, I move towards exploring the context of the inter-war period as well as the discursive construction of political corruption within the law and through the fascist criticism levelled against it.
Algebraic constraints and algorithms for common lines in cryo-EM
Authors: Muller Tommi , Duncan Adriana L. , Verbeke Eric J. , Kileel Joe 
Published: May 2024

Abstract
We revisit the topic of common lines between projection images in single-particle cryo-electron microscopy (cryo-EM). We derive a novel low-rank constraint on a certain 2n × n matrix storing properly scaled basis vectors for the common lines between n projection images of one molecular conformation. Using this algebraic constraint and others, we give optimization algorithms to denoise common lines and recover the unknown 3D rotations associated with the images. As an application, we develop a clustering algorithm to partition a set of noisy images into homogeneous communities using common lines, in the case of discrete heterogeneity in cryo-EM. We demonstrate the methods on synthetic and experimental datasets.
Pink purslane (Portulaca pilosa) control with postemergence herbicides
Authors: Shay Nicholas J. , Prostko Eric P. 
Published: May 2024

Abstract
Pink purslane is often ranked as one of the most troublesome weeds in vegetable production systems in Georgia. Pink purslane encroachment along field edges and in-field of agronomic crops has recently increased. Postemergence herbicides are an effective component of agronomic crop weed management. However, little research has addressed pink purslane control in agronomic crops. Therefore, greenhouse and field studies were conducted from 2022 to 2023 in Tifton, Georgia, to evaluate the response of pink purslane to postemergence herbicides commonly used in agronomic crops. Greenhouse screening provided preliminary evidence whereby 13 of the 21 postemergence herbicides evaluated provided ≥80% aboveground biomass reductions. These 13 herbicides were then used for field studies. Results from the field studies, pooled across two locations, indicated that only three of the 13 herbicides provided aboveground biomass reductions of ≥70% compared to the nontreated control. Those herbicides included atrazine at 1,682 g ai ha−1, glufosinate at 656 g ai ha−1, and lactofen at 219 g ai ha−1 with 79%, 70%, and 83% biomass reduction, respectively (P < 0.05). This research suggests that many of the postemergence herbicides used on agronomic crops will not effectively control pink purslane. Thus, when trying to manage pink purslane with postemergence herbicides in agronomic crops, growers should plant crops or cultivars that are tolerant of either atrazine, glufosinate, lactofen, or a combination of these.
Morphology‐Dependent Magnetic Properties in Shallow‐Water Ferromanganese Concretions
Authors: Wasiljeff Joonas , Salminen Johanna M. , Roberts Andrew P. , Hu Pengxiang , Brown Maxwell , Kuva Jukka , Lukkari Sari , Jolis Ester M. , Heinsalu Atko , Hong Wei‐Li , Lepland Aivo , Suuroja Sten , Parkkonen Joni , Virtasalo Joonas J. 
Published: May 2024

AbstractFerromanganese concretions commonly occur in shallow‐water coastal regions worldwide. In the Baltic Sea, they can record information about past and present underwater environments and could be a potential source for critical raw materials. We report on their microstructural characteristics and magnetic properties and link them to their formation mechanisms and environmental significance. Microstructural investigations from nano‐ and micro‐computed tomography, electron microscopy, and micro‐X‐ray fluorescence elemental mapping reveal diverse growth patterns within concretions of different morphologies. Alternating Fe‐ and Mn‐rich growth bands indicate fluctuating redox conditions during formation. Bullet‐shaped magnetofossils, produced by magnetotactic bacteria, are present, which suggests the influence of bacterial activity on concretion formation. Spheroidal concretions, which occur in deeper and more tranquil environments, have enhanced microbial biomineralization and magnetofossil preservation. Conversely, crusts and discoidal concretions from shallower and more energetic environments contain fewer magnetofossils and have a greater detrital content. Our results provide insights into concretion formation mechanisms and highlight the importance of diagenetic processes, oxygen availability, and bacterial activity in the Baltic Sea.
Latitudinal Profiles of Auroral Forms/Motions and Plasma Properties Based on Simultaneous Image‐Particle Measurements by Reimei in the Midnight Auroral Oval
Authors: Hirahara Masafumi , Fukuda Yoko , Ebihara Yusuke , Seki Kanako , Sakanoi Takeshi , Asamura Kazushi , Takada Taku , Yamazaki Atsushi , Kasaba Yasumasa , Saito Hirobumi 
Published: May 2024

AbstractWe present the simultaneous and conjugated auroral emission and particle data obtained by a low‐altitude polar‐orbiting micro‐satellite, Reimei, for elucidating their latitudinal distributions and variations in the nightside auroral oval. Here are reported a few notable examples of the Reimei observations with high time and spatial resolutions, namely ∼120 msec. and ∼1.2 km × 1.2 km for multispectral auroral images and 40 msec. for energy‐pitch angle distributions of electrons and ions with energies of 10 eV–12 keV, respectively. The auroral images show various fine‐scale auroral activities characterized by the following types of auroral forms and variations: faint bands, streaming multiple arcs, shearing arcs, and vortices/curls, which are typical of the latitudinal properties of auroras. The particle analyzer simultaneously observed various properties of electron energy‐pitch angle and latitudinal distributions, and their temporal variations, each of which corresponds to a type of the auroral activities. Their features are summarized below. Reimei repetitively observed inverted‐V signatures of low‐energy (<1 keV) field‐aligned electrons in addition to the higher‐energy (several keV) diffuse electrons in low‐latitude auroral oval. In more active regions at higher latitudes, the dominant energy flux responsible for the multiple‐arc emissions was carried by the well‐known inverted‐V electron precipitation. The rapidly rotating vortices or so‐called curls of fine‐scale discrete auroras near the poleward boundary of the auroral oval were closely associated with the significant energy fluxes of spiky field‐aligned electron bursts with energy‐time dispersions produced by dispersive Alfvén waves.
A Numerical Study on the Impact of E × B Drift on the Vertical Distribution of the Plasma Density Over the Geomagnetic Equatorial Ionospheric Region
Authors: Ashok Arya , Ambili K. M. , Choudhary R. K. 
Published: May 2024

AbstractUsing an in–house developed Quasi Two–Dimensional (QTD) physics–based ionospheric model, the impact of E × B drift velocity on the vertical distribution of the electron density over the equatorial latitude has been investigated. The vertical drift measurements from (a) drift analysis software of Digisonde (b) derived from Digisonde ionograms (c) calculated from the Scherliess–Fejer (SF) model, and (d) obtained from the magnetometer ΔH measurements have been used in this study. Four quiet days in a low solar activity year, representing four seasons of the year 2010, have been chosen for the study. The model–derived electron density profiles using the vertical drifts from all four methods matched well with the Digisonde observation below ∼150 km at all the Local Times (LTs) for all 4 days. However, since the Digisonde–derived drifts were very low, centered mostly around zero, it led to the overestimation/underestimation of the F–region peak plasma density (nmF2)/height (hmF2). The model simulated electron density profiles using the SF model, and ΔH derived vertical drifts showed good agreement with the observation up to an altitude of ∼350 km. The study showed that vertical drift is a factor that controls the nmF2 trough around noon over the equatorial latitude. It is seen that plasma diffusion occurs only beyond an altitude of 350 km, while the range of altitudes between 320 and 350 km acts as the “diffusion threshold height.” This finding has significant implications for understanding plasma dynamics in the equatorial ionosphere.
Forecasting 24‐Hr Total Electron Content With Long Short‐Term Memory Neural Network
Authors: Adolfs Marjolijn , Hoque Mohammed Mainul , Shprits Yuri Y. 
Published: May 2024

AbstractAn accurate prediction of the ionospheric state is important for correcting ionospheric propagation effects on Global Navigation Satellite Systems (GNSS) signals used in precise navigation and positioning applications. The main objective of the present work is to find a total electron content (TEC) model which gives a good estimate of ionospheric state not only during quiet but also during perturbed ionospheric conditions. For this, we implemented several long short‐term memory (LSTM)‐based models capable of predicting TEC up to 24 hr ahead. For the first time, we used the solar wind forcing parameters Wprot (a measure of the ionospheric disturbance during storm time) and Econv (measure of the solar wind parameters) as driver parameters. We found that using external drivers does not improve the accuracy of TEC predictions significantly. The final model is trained with data from the last two solar cycles using TEC from the rapid UQRG global ionosphere maps (GIMs). Data from the years 2015 and 2020 were excluded from the training data set and used for testing. The performance of the LSTM‐based TEC model is tested for near real‐time (RT) cases as well by using RT products (IRTG GIMs) as historical TEC inputs. We compared the performance of the LSTM‐based model to a quiet‐time feed forward neural network (FNN)‐based model and the Neustrelitz TEC model (NTCM). The results indicate that the LSTM‐based model proposed here is outperforming the FNN‐based model and NTCM in both cases, that is, using the UQRG or the IRTG GIMs as input for the historical TEC.
Crossover from gas-like to liquid-like molecular diffusion in a simple supercritical fluid
Authors: Ranieri Umbertoluca , Formisano Ferdinando , Gorelli Federico A. , Santoro Mario , Koza Michael Marek , De Francesco Alessio , Bove Livia E. 
Published: May 2024

AbstractAccording to textbooks, no physical observable can be discerned allowing to distinguish a liquid from a gas beyond the critical point. Yet, several proposals have been put forward challenging this view and various transition boundaries between a gas-like and a liquid-like behaviour, including the so-called Widom and Frenkel lines, and percolation line, have been suggested to delineate the supercritical state space. Here we report observation of a crossover from gas-like (Gaussian) to liquid-like (Lorentzian) self-dynamic structure factor by incoherent quasi-elastic neutron scattering measurements on supercritical fluid methane as a function of pressure, along the 200 K isotherm. The molecular self-diffusion coefficient was derived from the best Gaussian (at low pressures) or Lorentzian (at high pressures) fits to the neutron spectra. The Gaussian-to-Lorentzian crossover is progressive and takes place at about the Widom line intercept (59 bar). At considerably higher pressures, a liquid-like jump diffusion mechanism properly describes the supercritical fluid on both sides of the Frenkel line. The present observation of a gas-like to liquid-like crossover in the self dynamics of a simple supercritical fluid confirms emerging views on the unexpectedly complex physics of the supercritical state, and could have planet-wide implications and possible industrial applications in green chemistry.
FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation
Authors: Bhakuni Teena , Norden Pieter R. , Ujiie Naoto , Tan Can , Lee Sun Kyong , Tedeschi Thomas , Hsieh Yi-Wen , Wang Ying , Liu Ting , Fawzi Amani A. , Kume Tsutomu 
Published: May 2024

AbstractAngiogenesis, the growth of new blood vessels from pre-existing vasculature, is essential for the development of new organ systems, but transcriptional control of angiogenesis remains incompletely understood. Here we show that FOXC1 is essential for retinal angiogenesis. Endothelial cell (EC)-specific loss of Foxc1 impairs retinal vascular growth and expression of Slc3a2 and Slc7a5, which encode the heterodimeric CD98 (LAT1/4F2hc) amino acid transporter and regulate the intracellular transport of essential amino acids and activation of the mammalian target of rapamycin (mTOR). EC-Foxc1 deficiency diminishes mTOR activity, while administration of the mTOR agonist MHY-1485 rescues perturbed retinal angiogenesis. EC-Foxc1 expression is required for retinal revascularization and resolution of neovascular tufts in a model of oxygen-induced retinopathy. Foxc1 is also indispensable for pericytes, a critical component of the blood-retina barrier during retinal angiogenesis. Our findings establish FOXC1 as a crucial regulator of retinal vessels and identify therapeutic targets for treating retinal vascular disease.
Single-zinc vacancy unlocks high-rate H2O2 electrosynthesis from mixed dioxygen beyond Le Chatelier principle
Authors: Huang Qi , Xia Baokai , Li Ming , Guan Hongxin , Antonietti Markus , Chen Sheng 
Published: May 2024

Abstract
Le Chatelier’s principle is a basic rule in textbook defining the correlations of reaction activities and specific system parameters (like concentrations), serving as the guideline for regulating chemical/catalytic systems. Here we report a model system breaking this constraint in O2 electroreduction in mixed dioxygen. We unravel the central role of creating single-zinc vacancies in a crystal structure that leads to enzyme-like binding of the catalyst with enhanced selectivity to O2, shifting the reaction pathway from Langmuir-Hinshelwood to an upgraded triple-phase Eley-Rideal mechanism. The model system shows minute activity alteration of H2O2 yields (25.89~24.99 mol gcat
−1 h−1) and Faradaic efficiencies (92.5%~89.3%) in the O2 levels of 100%~21% at the current density of 50~300 mA cm−2, which apparently violate macroscopic Le Chatelier’s reaction kinetics. A standalone prototype device is built for high-rate H2O2 production from atmospheric air, achieving the highest Faradaic efficiencies of 87.8% at 320 mA cm−2, overtaking the state-of-the-art catalysts and approaching the theoretical limit for direct air electrolysis (~345.8 mA cm−2). Further techno-economics analyses display the use of atmospheric air feedstock affording 21.7% better economics as comparison to high-purity O2, achieving the lowest H2O2 capital cost of 0.3 $ Kg−1. Given the recent surge of demonstrations on tailoring chemical/catalytic systems based on the Le Chatelier’s principle, the present finding would have general implications, allowing for leveraging systems “beyond” this classical rule.
Severe drought exposure in utero associates to children’s epigenetic age acceleration in a global climate change hot spot
Authors: Qiao Xi , Straight Bilinda , Ngo Duy , Hilton Charles E. , Owuor Olungah Charles , Naugle Amy , Lalancette Claudia , Needham Belinda L. 
Published: May 2024

AbstractThe goal of this study is to examine the association between in utero drought exposure and epigenetic age acceleration (EAA) in a global climate change hot spot. Calculations of EAA in adults using DNA methylation have been found to accurately predict chronic disease and longevity. However, fewer studies have examined EAA in children, and drought exposure in utero has not been investigated. Additionally, studies of EAA in low-income countries with diverse populations are rare. We assess EAA using epigenetic clocks and two DNAm-based pace-of-aging measurements from whole saliva samples in 104 drought-exposed children and 109 same-sex sibling controls in northern Kenya. We find a positive association between in utero drought exposure and EAA in two epigenetic clocks (Hannum’s and GrimAge) and a negative association in the DNAm based telomere length (DNAmTL) clock. The combined impact of drought’s multiple deleterious stressors may reduce overall life expectancy through accelerated epigenetic aging.
Mechanical-scan-free multicolor super-resolution imaging with diffractive spot array illumination
Authors: Xu Ning , Bohndiek Sarah E. , Li Zexing , Zhang Cilong , Tan Qiaofeng 
Published: May 2024

AbstractPoint-scanning microscopy approaches are transforming super-resolution imaging. Despite achieving parallel high-speed imaging using multifocal techniques, efficient multicolor imaging methods with high-quality illumination are currently lacking. In this paper, we present for the first time Mechanical-scan-free multiColor Super-resolution Microscopy (MCoSM) with spot array illumination, which enables mechanical-scan-free super-resolution imaging with adjustable resolution and a good effective field-of-view based on spatial light modulators. Through 100–2,500 s super-resolution spot illumination with different effective fields of view for imaging, we demonstrate the adjustable capacity of MCoSM. MCoSM extends existing spectral imaging capabilities through a time-sharing process involving different color illumination with phase-shift scanning while retaining the spatial flexibility of super-resolution imaging with diffractive spot array illumination. To demonstrate the prospects of MCoSM, we perform four-color imaging of fluorescent beads at high resolution. MCoSM provides a versatile platform for studying molecular interactions in complex samples at the nanoscale level.
Optogenetic activation of dorsal raphe serotonin neurons induces brain-wide activation
Authors: Hamada Hiro Taiyo , Abe Yoshifumi , Takata Norio , Taira Masakazu , Tanaka Kenji F. , Doya Kenji 
Published: May 2024

AbstractSerotonin is a neuromodulator that affects multiple behavioral and cognitive functions. Nonetheless, how serotonin causes such a variety of effects via brain-wide projections and various receptors remains unclear. Here we measured brain-wide responses to optogenetic stimulation of serotonin neurons in the dorsal raphe nucleus (DRN) of the male mouse brain using functional MRI with an 11.7 T scanner and a cryoprobe. Transient activation of DRN serotonin neurons caused brain-wide activation, including the medial prefrontal cortex, the striatum, and the ventral tegmental area. The same stimulation under anesthesia with isoflurane decreased brain-wide activation, including the hippocampal complex. These brain-wide response patterns can be explained by DRN serotonergic projection topography and serotonin receptor expression profiles, with enhanced weights on 5-HT1 receptors. Together, these results provide insight into the DR serotonergic system, which is consistent with recent discoveries of its functions in adaptive behaviors.
Early planetesimal differentiation and late accretion shaped Earth’s nitrogen budget
Authors: Wang Wenzhong , Walter Michael J. , Brodholt John P. , Huang Shichun 
Published: May 2024

AbstractThe relative roles of protoplanetary differentiation versus late accretion in establishing Earth’s life-essential volatile element inventory are being hotly debated. To address this issue, we employ first-principles calculations to investigate nitrogen (N) isotope fractionation during Earth’s accretion and differentiation. We find that segregation of an iron core would enrich heavy N isotopes in the residual silicate, while evaporation within a H2-dominated nebular gas produces an enrichment of light N isotope in the planetesimals. The combined effect of early planetesimal evaporation followed by core formation enriches the bulk silicate Earth in light N isotopes. If Earth is comprised primarily of enstatite-chondrite-like material, as indicated by other isotope systems, then late accretion of carbonaceous-chondrite-like material must contribute ~ 30–100% of the N budget in present-day bulk silicate Earth. However, mass balance using N isotope constraints shows that the late veneer contributes only a limited amount of other volatile elements (e.g., H, S, and C) to Earth.
The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction
Authors: Gao Xiaopan , Wang Bei , Zhu Kaixiang , Wang Linyue , Qin Bo , Shang Kun , Ding Wei , Wang Jianwei , Cui Sheng 
Published: May 2024

AbstractSETD3 is an essential host factor for the replication of a variety of enteroviruses that specifically interacts with viral protease 2A. However, the interaction between SETD3 and the 2A protease has not been fully characterized. Here, we use X-ray crystallography and cryo-electron microscopy to determine the structures of SETD3 complexed with the 2A protease of EV71 to 3.5 Å and 3.1 Å resolution, respectively. We find that the 2A protease occupies the V-shaped central cleft of SETD3 through two discrete sites. The relative positions of the two proteins vary in the crystal and cryo-EM structures, showing dynamic binding. A biolayer interferometry assay shows that the EV71 2A protease outcompetes actin for SETD3 binding. We identify key 2A residues involved in SETD3 binding and demonstrate that 2A’s ability to bind SETD3 correlates with EV71 production in cells. Coimmunoprecipitation experiments in EV71 infected and 2A expressing cells indicate that 2A interferes with the SETD3-actin complex, and the disruption of this complex reduces enterovirus replication. Together, these results reveal the molecular mechanism underlying the interplay between SETD3, actin, and viral 2A during virus replication.