bluuebunny/crossref_metadata_2025_split huggingface dataset:
Securing DICOM Images with a Novel Chaotic Encryption Scheme Utilizing Wavelet Transform and Biometric Fingerprint
Authors: Mortajez Sareh , Dehghan Mohammad Jafar , Azizi Amirabbas 
Published: June 2024

Abstract

Medical images contain sensitive diagnostic and therapeutic information about patients. The confidentiality of medical images is crucial, particularly in telehealth. Data encryption is a vital method for protecting such sensitive information. One of the most common methods for ensuring information security is data encryption, and image encryption is a common process for protecting visual data.
This paper presents a novel encryption scheme for DICOM medical images, integrating chaotic logistic systems, discrete wavelet transforms, and biometric fingerprint data. The method generates dynamic, interdependent security keys by combining DICOM image data with fingerprint information. Pixels confusion phase is achieved through a block-based strategy and a multi-level map structure, while diffusion phase employs a threshold-based strategy based on chaotic logistic systems. The encryption of DICOM images is accomplished with very low computational complexity. The proposed method demonstrates a significant trade-off between computational complexity and security performance with its simplicity of implementation.
We tested the scheme on standard DICOM images, assessing security through entropy, key sensitivity, key space, correlation, and histogram analyses. Comparative studies under identical conditions revealed superior performance of our scheme over existing methods.
In the presented scheme, dynamic security keys are generated for each input medical image based on DICOM and fingerprint information. Our scheme's dynamic security keys, tailored to each medical image, offer a balance between computational efficiency and robust security. The simplicity of implementation, coupled with rigorous evaluation, confirms the method's effectiveness against security threats, making it a promising solution for medical image encryption in telehealth.
The impact of changes in physical activity on functional recovery for older inpatients in community-based integrated care units
Authors: Saegusa Hiroki , Kojima Iwao , Terao Yusuke , Koyama Shingo , Suzuki Mizue , Tanaka Shu , Kimura Yosuke , Otobe Yuhei , Aoki Takuya , Nishida Sho , Kitagawa Yasuhiro , Yamada Minoru 
Published: June 2024

Abstract

Purpose
The effect of increased physical activity duration on functional recovery in older inpatients in subacute settings is not well established. This study aimed to investigate the relationship between physical activity and functional recovery in older patients receiving post-acute and subacute care.
Methods
We analyzed cohort data of hospitalized older patients (age ≥ 65 years) in the community-based integrated care units. The main outcome was functional independence measure (FIM) gain. Physical activity was measured using a triaxial accelerometer. Changes in sedentary behavior and total physical activity time from admission to discharge were measured as changes in each physical activity time. Logistic regression analysis was performed to examine the relationship between changes in physical activity and FIM gain.
Results
A total of 210 patients were eligible for analysis. The mean age of the study patients was 83.6 ± 7.2 years, and 63.8% (n = 134) were female. According to the multivariate regression analysis, changes in sedentary behavior time were significantly associated with better recovery of FIM gain (odds ratio [OR] 0.996, 95% confidence interval [CI]: 0.992–0.999; p = 0.018), and changes in total physical activity time also showed a similar association (OR 1.006, 95% CI: 1.001–1.011; p = 0.023).
Conclusion
Decreased sedentary behavior time and increased total physical activity time were significantly associated with better functional recovery in community-based integrated care units. These results suggest that interventions for physical activity duration may be effective in older post-acute and subacute patients.
Elucidating the G X E Interaction Using AMMI, AMMI Stability Parameters and GGE for Cane Yield and Quality in Sugarcane
Authors: DURAI A.ANNA , . Amaresh , R Arun kumar , G Hemaprabha 
Published: June 2024

Abstract

Stable, and high yielding genotype with superior quality across the spatial and temporal variation are to be identified due to changing weather conditions which largely influences the true genotypic performance. The present experiment was conducted with 13 clones including seven test entries along with six recently released varieties as first plant, second plant and ratoon in RBD with three replications during the year 2022-23 and 2023-24 at ICAR-SBI, Coimbatore. Combined ANOVA revealed that there was a significant genotype main effects, environment main effects and G X E interaction effect for all the traits under study except for the traits, cane diameter and single cane weight for which environment main effects were not significant. The AMMI ANOVA for the sucrose, CCS percent, cane yield and CCS yield showed that significant individual effects of Genotypes, Environments and genotype × environment interaction. AMMI biplot analysis revealed that the genotypes Co 17001, CoC 13339 and Co 86032 for cane yield and Co 86032 and CoC 13339 for CCS yield were stable. AMMI stability parameters such as ASV, MASV identified Co 86032, Co 15003, and CoC 13339 were stable for cane and CCS yield. The GSI, EV, SIPC showed Co 17001, Co 15003, Co 86032 and Co 11015 were stable for cane and CCS yield. Multi-trait stability analysis considering the traits like sucrose, CCS percent, cane yield, CCS yield revealed that the genotypes Co 15003 and Co 86032 were highly stable. GGE analysis such as mean vs stability, ranking of genotypes, which won where biplots pinpointed that the genotype Co 17001 is highly stable than the standards Co 11015 and Co 86032 for sucrose content, cane and CCS yield. Thus, the genotypes Co 17001 and Co 15003 were stable and superior than the commercial varieties like Co 11015 and Co 86032 according to the AMMI, AMMI stability parameters and GGE for the cane yield and CCS yield and they may be promoted for commercial cultivation in target environment.
Uniting science and local ecological knowledge to address a recent invasion in a protected area
Authors: Padilha Janeide , Teixeira Amílcar , Sousa Ronaldo 
Published: June 2024

Abstract

Non-native invasive species threaten freshwater biodiversity and ecosystem services (ES), which are critical for environmental health and possess noteworthy socioeconomic and cultural importance. This research specifically delves into the impact of the signal crayfish (Pacifastacus leniusculus) in a protected area (Montesinho Natural Park, Portugal). It combines scientific inquiry with local ecological knowledge (LEK) to elucidate the implications of this non-native invasive species for biodiversity and ES across five river basins. Data was collected through face-to-face interviews with 132 residents from villages adjacent to these rivers, maintaining a balanced representation of both genders. Approximately 46% of the males and 25.5% of the females reported sightings of the signal crayfish, describing initial introductions around 8 and 5.8 years ago, respectively. The majority (78.6% of men and 80% of women) believed that the crayfish populations have since burgeoned. Respondents evaluated the crayfish's ES impact on a 0-5 scale, with 5 being the most significant. Both genders recognized the impacts on different ES, such as riverbank erosion (1.5), food sources for humans (2.5) and other species (3.8), water quality (3.3), pest regulation (3), habitat provision (3.9), and recreational and tourism activities (2.8). Both men (87.5%) and women (77.8%) identified fish, specifically brown trout (Salmo trutta), as the most affected taxonomic group by this non-native invasive species. Unanimously, participants concurred on the importance of integrating LEK with scientific research to improve invasive species management. The findings emphasize the urgent need for robust scientific study and targeted management actions considering the perceived detrimental negative impacts of signal crayfish. It suggests the crucial role of local communities in knowledge generation and response formulation, thus reinforcing our collective efforts to safeguard biodiversity and ES amidst invasive species threats.
Establishment and clinical application of fetal growth charts: A retrospective observational study in Wuhan China
Authors: Yu Nan , Li Wei , Li Jin , Wang Liang , Yang Yihong , Feng Ling , Wu Jianli 
Published: June 2024

Abstract

Background
Optimal fetal growth is recognized as a basic foundation for long-term health, while aberrations in growth may have implications for disease risk across the lifespan. We attempted to establish the best evaluation method of fetal growth curve suitable for Chinese children, and evaluate the impact of this chart and other charts used for a long time in a Chinese population, such as Hadlock chart, and to compare their ability to predict newborn small for gestational age (SGA).
Methods
For this retrospective observational study, we reviewed ultrasound data from all pregnant women (n = 29286) who gave birth in Tongji Hospital between 2007 and 2022. A fractional polynomial regression model was applied to generate Wuhan fetal growth chart ranges for head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL). The differences between Wuhan charts and published charts were quantified by calculating the Z-score.
Results
33982 scans of fetal biometry contributed by 29286 pregnancies with reliable gestational age were analyzed. With Hadlock references (< 3rd centile), the proportions of small heads and short femurs were 8.23% and 11.98% in late gestation respectively. With AC < 10th centile, all these references were poor at predicting neonatal SGA and short femur.
Conclusions
Applying long-standing Hadlock references could misclassify a large proportion of fetuses as SGA and short femurs. A curve that is more suitable for Chinese fetus is urgently needed.
Assessing the Discrepancy between Network and Household Drinking Water Quality in Rural Cundinamarca, Colombia
Authors: Galezzo María-Angélica , Acosta-González Alejandro , Jimenez-Junca Carlos 
Published: June 2024

Abstract

In rural areas of Colombia, many communities regularly consume untreated water via rural aqueducts with little concern for water quality. Additionally, monitoring of water quality by local authorities is almost nonexistent. To evaluate drinking water quality in rural communities from the Sabana Centro province in Cundinamarca, Colombia, four representative locations (El Olivo, El Manzano, Alto del Aguila, and Río Frío Oriental) were selected for water analyses at three sampling points (tap, filtered water, and boiled water) in 58 households. The physical, chemical, and microbiological parameters of the water samples were used to calculate the IRCA (Water Quality Risk Index) and compared with the values established by Colombian regulations and WHO guidelines. Our findings indicate the IRCA ranged from 1.2 to 95.2, distributed as follows: 3% of samples had no risk, 19% medium risk, 43% high risk, and 34% were unsanitary. Significant differences in water quality were found between communities (p = 0.003) and sampling points (p < 0.001). A strong negative correlation (r = -0.729) between residual chlorine and fecal coliforms indicated effective bacterial reduction with chlorine treatment. Boiled water samples had the highest average IRCA value (81.3), while filtered water samples had the lowest (32.4). It is concluded that residents in the four communities face water-related health risks, as indicated by the IRCA. Filtration proved more effective in improving water quality than boiling or tap water usage. Implementing proper water management and storage practices, complemented by community training, is essential to enhance water safety and public health.
The value of elective neck irradiation in management of esthesioneuroblastoma: a retrospective study based on Propensity Score Matching
Authors: Zhao Yang , Yan Li , Li Ruichen , Wang Xiaoshen , Zhu Yi 
Published: June 2024

Abstract

Background
This study aims to assess the clinical efficacy of elective neck irradiation (ENI) in patients with esthesineuroblastoma (ENB), a rare malignant neoplasm, who are clinically node-negative.
Methods
We conducted a retrospective analysis of 178 patients newly diagnosed with ENB at our institution between 2009 and 2021. Propensity score matching (PSM) was employed to compare node-negative patients treated with and without ENI. We extensively examined survival outcomes and treatment failure.
Results
Of the 178 participants, 149 (83.7%) were lymph node-negative and staged in Modified Kadish A-C. 96 patients underwent ENI treatment, while 53 did not. At baseline, patients who received ENI differed from those who did not in terms of radiotherapy technique, staging, orbital invasion, surgical mode, and chemotherapy. After PSM, 43 pairs were available for analysis. ENI was observed to extend overall survival (OS, 5-year 73.9% vs. 84.0%; 3-year 76.9% vs. 97.1%, p = 0.022), progression-free survival (PFS, 5-year 38.5% vs. 84.6%; 3-year 50.5% vs. 94.5%, p < 0.001) and locoregional relapse-free survival (LRFS, 5-year 42.7% vs. 84.6%, p = 0.023; 3-year 57.3% vs. 94.5%, p < 0.001) in node-negative ENI patients. Failure pattern analyses revealed that ENI, which included level Ib, II, VIIa, significantly reduced the treatment failure rate. Furthermore, ENI did not significantly impact the prognosis of T1-2 patients, indicating potential clinical value of ENI in T3-4 patients.
Conclusions
Our findings suggested that ENI decreased regional failure and significantly enhanced LRFS and PFS. ENI may be considered as an integral part of the initial treatment strategy for locally advanced node-negative ENB patients.
Comparison of rebubbling rate between preloaded endothelium-in and preloaded no-touch endothelium-out Descemet membrane endothelial keratoplasty transplantation
Authors: Kronschläger Martin , Ruzza Alessandro , Zeilinger Johannes , Schlatter Andreas , Ruiss Manuel , Findl Oliver 
Published: June 2024

Abstract

Background
To compare the difference in rebubbling rates between patients undergoing Descemet membrane endothelial keratoplasty (DMEK) with endothelium-in using a standard IOL cartridge and those with endothelium-out DMEK utilizing a no-touch technique with borosilicate glass cartridge transplantation.
Methods
This retrospective study included all eyes that underwent preloaded endothelium-in or endothelium-out DMEK transplantation from June 2019 to December 2023 at the Hanusch Hospital, Vienna, Austria. All DMEKs were harvested, prepared and preloaded at the European Eye Bank of Venice, Italy. DMEK surgeries were done by one experienced surgeon and the procedure was completed by air tamponade of the anterior chamber.
Results
Overall, 32 eyes each of 31 endothelium-out patients and of 29 endothelium-in patients were included. 32 preloaded endothelium-in procedures were followed by 32 preloaded endothelium-out procedures. Rebubbling rate for endothelium-in was 15/32 (47%) and for endothelium-out was 7/25 (28%) (p = 0.035, Pearson's chi-squared test). Donor age was the most important variable for rebubbling in a random forest algorithm model (ROC: 0.67).
Conclusions
Rebubbling rate in endothelium-out DMEK was less than two-thirds compared to endothelium-in DMEK favoring no-touch endothelium-out DMEK as the preferred technique of DMEK transplantation.
Developing a PANoptosis Signature: Identification of Unique Immunotherapeutic Candidates for Osteosarcoma
Authors: Zhou Song , Zhou Jing , Li Lianxiang , Song Bo , Cheng Yuelei , Xie Wei , Zhao Yunlai , Yang Feng , Zhuang Qishuai , Zhang Qian 
Published: June 2024

Abstract

This study focused on elucidating the role of PANoptosis in osteosarcoma (OS), a highly malignant bone tumor. By screening and integrating OS-related microarray datasets from GEO, we identified 105 PANoptosis-related differentially expressed genes (OS_PAN_DEGs) primarily involved in apoptosis, necroptosis, proteasome, Hippo signaling, and neurodegenerative disease pathways. These genes were used to classify OS into three distinct subtypes with varying clinical outcomes, immune characteristics, and mutational landscapes. Additionally, we developed an OS_PAN-index model to assess the association between PANoptosis and OS features, treatment response, and prognosis. Notably, high OS_PAN-index patients responded well to immunotherapy, while low-index patients showed sensitivity to small-molecule targeted drugs. Drug screening revealed Pazopanib, Chelerythrine, Staurosporine, Hydroxyurea, and Sunitinib as potential therapeutic agents positively correlated with OS_PAN_DEGs expression. This comprehensive analysis enhances our understanding of OS pathogenesis and offers novel therapeutic targets for OS treatment.
The association between the uric acid-to-high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data (2011–2018)
Authors: Wang Jinzhou , Li Shanshan , Pu Hongyu , Wang Ye 
Published: June 2024

Abstract

Background
Middle-aged and older persons are frequently afflicted with osteoporosis and atherosclerosis; however, new evidence indicates a deeper relationship that goes beyond the normal aging process. One new inflammatory measure that has developed for evaluating the risk of cardiovascular disease is the uric acid to high density lipoprotein ratio (UHR).However, research on the relationship between UHR and the risk of developing osteoporosis is still awaiting.
Methods
Between 2011 and 2018, we gathered UHR and bone mineral density (BMD) data from 10,983 individuals in the National Health and Nutrition Examination Survey (NHANES). We employed multivariate linear regression to investigate the relationship between BMD and UHR. Smoothing curves were utilized to deal with nonlinearity. To investigate nonlinear relationships further, we employed a two-part linear regression model. Threshold effects were evaluated using both components of the linear regression model. We also conducted subgroup analyses to ensure the stability of the findings.
Results
In all three models, we found a negative correlation between UHR and lumbar BMD. there was an L-curve correlation between UHR and lumbar BMD, with a critical inflection point of 2.97. the fully adjusted model showed a decrease in lumbar BMD of 0.03 g/cm2 for those in the fourth quartile compared with the lowest quartile. the correlation was consistent across most subgroups, except in the subgroups with a body mass index less than 25 and age greater than 50 and those with diabetes.
Conclusions
According to this study, there appears to be a negative relationship between BMD and NHHR among US adults. More study is needed to determine the precise physiological pathways by which UHR contributes to the development of osteoporosis.
Long-Term Clinical Effectiveness and Associated Factors of Drug-Coated Balloon for Long and Short Femoropopliteal Lesion
Authors: Wang Yuru , Li Kang , Shao Jiang , Lai Zhichao , Xie Yiyun , Kong Deqiang , Liu Bao 
Published: June 2024

Abstract

Purpose
The efficacy and safety of drug-coated balloons (DCBs) for the treatment of short femoropopliteal arteries have been demonstrated. However, there are few studies on the prognosis of long lesions, especially long-term prognosis. The purpose of this study was to compare the long-term outcomes of DCB for long and short lesions and the risk factors associated with poor prognosis.
Methods
This real-world and single-center cohort study included 234 patients with de novo stenosis or restenosis of the femoropopliteal arteries (115 long lesions, 141 short lesions) who underwent successful DCB treatment from January 2019 to December 2021 at Peking Union Medical College Hospital. Stents were also used in 18 long lesions (15.7%) and 14 short lesions (9.9%). The primary safety endpoint was defined as freedom from major adverse events. Major adverse events were defined as death, target limb amputation or thrombosis. The primary efficacy endpoint was defined as primary patency and freedom from target lesion revascularization (TLR). The mean follow-up period was 2 years.
Results
Major adverse events at 2-year follow-up were reported in 12.4% of patients (29/234). The rate of primary patency and freedom from TLR by Kaplan-Meier estimation was 56.10 ± 3.28% and 85.71 ± 2.32% at 2 years, respectively. Significant difference in primary patency is shown in Rutherford Clinical Category (RCC) (p = 0.003), lesion length > 15cm versus ≤ 15cm (p = 0.005), target vessel = 1 versus target vessels = 2 (p = 0.018). Cox analysis suggested that Lesion length > 15 cm and RCC > 3 were associated with increased risk for primary patency loss at 2 years (p < 0.05). The change in RCC between baseline and 2-year follow-up was available in 199 patients with significant difference (p < 0.001).
Conclusion
DCB treatment is safe and effective at 2 years postoperatively. Patients with longer lesions, RCC > 3 had significantly lower rates of primary patency.
Isolation of Acetic Acid Bacteria (AAB) from Pollen and Honey of Mellipona Subnitida Stingless Bees
Authors: Alves Andreza Marta Pereira , Silveira Maico Silva , Alves Luis Kenedy , Ramírez María Ximena Díaz , Silva Jonas Luiz Almada , Pereira Júlio Otávio Portela , Silva Mayara Salgado 
Published: June 2024

Abstract

Vinegar production worldwide typically follows a natural fermentation process, which complicates control and standardization procedures. To streamline this process, it is essential to develop fermenting agents with high acetic acid production through acetic acid bacteria (AAB). The acetic acid present in the pollen of stingless bees is the most sensorially prominent organic acid, confirming that this bee product undergoes a fermentation process. This study aimed to isolate acetic acid bacteria from the pollen of Melipona subnitida bees, which are native to Brazil and whose products remain underexplored.. Thirteen strains were isolated from the pollen and one strain from kombucha as a control. The biochemical tests performed were: Gram staining, catalase production, H₂S production, indole production, motility, and catalase production. Additionally, an acetic acid production test was performed in culture medium and honey alcoholic fermentate. ANOVA and Tukey's test were applied. Finally, four strains were selected: MV1, MA2, PV6, and K, as promising for acetic acid production.