bluuebunny/crossref_metadata_2025_split huggingface dataset:
Barley farmland harbors a highly homogeneous soil bacterial community compared to wild ecosystems in the Qinghai-Xizang Plateau
Authors: Wang Xiaolin , Yang Yibin , Nan Qiong , Guo Jian-Wei , Tan Zhiyuan , Shao Xiaoming , Tian Changfu 
Published: June 2024

IntroductionUnderstanding patterns and processes of microbial biogeography in soils is important for monitoring ecological responses to human activities, particularly in ecologically vulnerable areas such as the Qinghai-Xizang Plateau. Highland barley is the staple food of local people and has mainly been cultivated along the Yarlung Zangbo River valley in Xizang.MethodsHere we investigated soil bacterial communities from 33 sampling sites of highland barley farmland in this region and compared them to those from wild ecosystems including alpine tundra, meadow, forest, and swamp. Additionally, the effects of environmental factors on bacterial communities, as well as the relative importance of stochastic and deterministic processes in shaping the beta diversity of soil bacterial communities in alpine ecosystems were assessed.ResultsIn contrast to soils of wild ecosystems, these farmland samples harbored a highly homogeneous bacterial community without significant correlations with geographic, elevation, and edaphic distances. Discriminant bacterial taxa identified for farmland samples belong to Acidobacteria, with Acidobacteria Gp4 as the dominant clade. Although Acidobacteria were the most abundant members in all ecosystems, characterized bacterial taxa of meadow and forest were members of other phyla such as Proteobacteria and Verrucomicrobia. pH and organic matter were major edaphic attributes shaping these observed patterns across ecosystems. Null model analyses revealed that the deterministic assembly was dominant in bacterial communities in highland barley farmland and tundra soils, whereas stochastic assembly also contributed a large fraction to the assembly of bacterial communities in forest, meadow and swamp soils.DiscussionThese findings provide an insight into the consequences of human activities and agricultural intensification on taxonomic homogenization of soil bacterial communities in the Qinghai-Xizang Plateau.
Real-world evaluation of health-related quality of life in patients with diffuse large B-cell lymphoma based on a multinational survey
Authors: Johnson P. Connor , Bailey Abigail , Ma Qiufei , Milloy Neil , Butcher Jake , Sanderson Isaac , Weatherby Sarah , Meadows Rachael , Quek Ruben G. W. 
Published: June 2024

BackgroundReal-world health-related quality of life (HRQoL) data in patients with diffuse large B-cell lymphoma (DLBCL) are scarce. This study is to compare patient-reported outcomes in patients with DLBCL across therapy lines and countries.MethodsData were derived from the Adelphi DLBCL Disease Specific Programme™ from January 2021 to May 2021, a survey of physicians and their DLBCL patients in France, Germany, Italy, Spain, United Kingdom (UK), and the United States (US).ResultsOverall, analysis was conducted on 441 patients with DLBCL across Europe and the US (mean age 64.6 years, 64% male); 68% had an Ann Arbor stage III and 69% had an Eastern Cooperative Oncology Group Performance Status of 0 to 1. The mean overall GHS/QoL was 54.1; patients on their 3L+ therapy had a lower mean GHS/QoL compared with patients on 1L/2L (P = 0.0033). Further to this, mean EQ-5D-5L utility score was reduced from 0.73 for patients on 1L therapy to 0.66 for patients on 3L+ therapies (P = 0.0149). Mean percentages of impairment while working and overall work impairment were lower for patients receiving 3L+ therapy (12.5% and 17.7%; respectively) than those on 1L therapy (35.6% and 33.8%; respectively). When comparing region, patients in the US had significantly better scores for all functioning and symptomatic scales (per EORTC QLQ-C30) and work impairment (per WPAI) vs. patients with DLBCL in Europe. WPAI scores indicate that the overall activity impairment in the US was 36.6% and in Europe ranged from 42.4% in the UK to 54.9% in Germany. Mean EQ-5D-5L utility score for the US was 0.80, compared to 0.60 – 0.80 across the countries in Europe. Regression analysis showed patients who relapsed after more than one year of treatment were associated with better patient reported outcomes than those who relapse after less than one year.ConclusionPatient-reported outcomes of DLBCL patients remain poor and patients continue to experience considerable morbidity.
Pulmonary haemorrhage and haemoptysis associated with bevacizumab-related treatment regimens: a retrospective, pharmacovigilance study using the FAERS database
Authors: Hu Huiping , Fu Zhiwen , Liu Jinmei , Zhang Cong , Li Shijun , Zhang Yu , You Ruxu 
Published: June 2024

Background: Bevacizumab (BV) is widely used in routine cancer treatment and clinical therapy in combination with many other agents. This study aims to describe and analyse post-market cases of pulmonary haemorrhage and haemoptysis reported with different BV treatment regimens by mining data from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) database.Methods: Data were collected from the FAERS database between 2004 Q1 and 2023 Q1. Disproportionality analysis including the reporting odds ratio (ROR) was employed to quantify the signals of disproportionate reporting of pulmonary haemorrhage and haemoptysis adverse events (AEs) associated with BV-related treatment regimens. The demographic characteristics, time to onset and outcomes were further clarified.Results: A total of 55,184 BV-associated reports were extracted from the FAERS database, of which 497 reports related to pulmonary haemorrhage and haemoptysis. Overall, the median onset time of pulmonary haemorrhage and haemoptysis AEs was 43 days (interquartile range (IQR) 15-117 days). In the subgroup analysis, BV plus targeted therapy had the longest median onset time of 90.5 days (IQR 34-178.5 days), while BV plus chemotherapy had the shortest of 40.5 days (IQR 14–90.25). BV plus chemotherapy disproportionately reported the highest percentage of death (148 deaths out of 292 cases, 50.68%). Moreover, the BV-related treatments including four subgroups in our study demonstrated the positive signals with the association of disproportionate reporting of pulmonary haemorrhage and haemoptysis. Notably, BV plus chemotherapy showed a significant higher reporting risk in pulmonary haemorrhage and haemoptysis signals of disproportionate reporting in comparison to BV monotherapy (ROR 5.35 [95% CI, 4.78–6.02] vs. ROR 4.19 [95% CI, 3.56–4.91], p = 0.0147).Conclusion: This study characterized the reporting of pulmonary haemorrhage and haemoptysis, along with the time to onset and demographic characteristics among different BV-related treatment options. It could provide valuable evidence for further studies and clinical practice of BV.
Effects of nitrogen addition and Bothriochloa ischaemum and Lespedeza davurica mixture on plant chlorophyll fluorescence and community production in semi-arid grassland
Authors: Wang Fugang , Shi Lei , Zhang Ruiyi , Xu Weizhou , Bo Yaojun 
Published: June 2024

BackgroundGrass-legume mixture can effectively improve productivity and stimulate overyielding in artificial grasslands, but may be N-limited in semi-arid regions. This study investigated the effects of N addition on chlorophyll fluorescence and production in the grass-legume mixtures community.MethodsAn N addition experiment was conducted in the Bothriochloa ischaemum and Lespedeza davurica mixture community, with seven mixture ratios (B0L10, B2L8, B4L6, B5L5, B6L4, B8L2, and B10L0) according to the sowing abundance of B.ischaemum and L.davurica and four N addition levels, N0, N25, N50, and N75 (0,25,50,75kgNhm-2 a-1), respectively. We analyzed the response of chlorophyll fluorescence parameters of the two species, the rapid light-response curves of chlorophyll fluorescence, as well as aboveground biomass (AGB) and overyielding.ResultsOur results showed that the two species showed different photosynthetic strategies, with L.davurica having significantly higher initial fluorescence (Fo), effective photochemical quantum yield of PSII (ΦPSII), and coefficient of photochemical fluorescence quenching (qP) than B. ischaemum, consisting with results of rapid light-response curves. N addition and mixture ratio both had significant effects on chlorophyll fluorescence and AGB (p&lt;0.001). The ΦPSII and qP of L.davurica were significantly lowest in B5L5 and B6L4 under N addition, and the effect of N varied with mixture ratio. The photosynthetic efficiency of B. ischaemum was higher in mixture than in monoculture (B10L0), and ΦPSII was significantly higher in N50 than in N25 and N50 at mixture communities except at B5L5. The community AGB was significantly higher in mixture communities than in two monocultures and highest at B6L4. In the same mixture ratio, the AGB was highest under the N50. The overyielding effects were significantly highest under the N75 and B6L4 treatments, mainly attributed to L.davurica. The partial least squares path models demonstrated that adding N increased soil nutrient content, and complementary utilization by B.ischaemum and L.davurica increased the photosynthetic efficiency. However, as the different photosynthetic strategies of these two species, the effect on AGB was offset, and the mixture ratio’s effects were larger than N. Our results proposed the B6L4 and N50 treatments were the optimal combination, with the highest AGB and overyielding, moderate grass-legume ratio, optimal community structure, and forage values.
Nonsuicidal self-injury among Chinese university students during the post-COVID-19 era: analysis of sex differences and the impact of gender role conflict
Authors: Xin Moye , Petrovic Julia , Yang Chengxi , Zhang Lijin , Yang Xueyan 
Published: June 2024

BackgroundGlobal centers of epidemic prevention and control have entered a new stage of normalization, namely, the “post-COVID-19 era.” During the post-COVID-19 era, which is characterized by the time period following that with the most serious medical consequences, the psychosocial consequences of the COVID-19 pandemic began to receive worldwide attention, especially the degree of psychological distress it caused.AimThis study explored the differential impact of gender role conflict on Chinese university students’ engagement in nonsuicidal self-injury (NSSI) as a function of biological sex following the global COVID-19 pandemic.MethodsParticipants were 1,600 university students in northwestern China (Mage = 21.3 years; 50.8% women) who completed online measures of demographic variables (including biological sex, gender role conflict, and NSSI engagement).ResultsWomen reported significantly more gender role conflicts than men did, while engagement in NSSI was significantly more prevalent among men than women. A total of 262 men reported engaging in at least one NSSI behavior, resulting in a prevalence rate of 33.25%. In comparison, a total of 106 individuals reported engaging in at least one NSSI behavior, resulting in a prevalence rate of 13.05% among women. Gender role conflict was found to significantly predict university students’ NSSI engagement, regardless of biological sex.ConclusionThis is the first empirical study to identify sex differences in both gender role conflict and engagement in NSSI among university students in Northwestern China during the post-COVID-19 era. In addition, the present study is the first to demonstrate how gender role conflict predicts engagement in NSSI across sexes. These findings will inform the literature on gender role conflict and NSSI, particularly the close relationship between gender role conflict and engagement in NSSI among Chinese university students, and they emphasize the need for continued efforts to explore NSSI cross-culturally.
Serine racemase deletion alters adolescent social behavior and whole-brain cFos activation
Authors: Brown Stephanie E. , Wang Ziyi (Zephyr) , Newman Emily L. , Engin Elif , Berretta Sabina , Balu Darrick T. , Folorunso Oluwarotimi O. 
Published: June 2024

BackgroundNeurodevelopmental disorders (NDDs) can cause debilitating impairments in social cognition and aberrant functional connectivity in large-scale brain networks, leading to social isolation and diminished everyday functioning. To facilitate the treatment of social impairments, animal models of NDDs that link N- methyl-D-aspartate receptor (NMDAR) hypofunction to social deficits in adulthood have been used. However, understanding the etiology of social impairments in NDDs requires investigating social changes during sensitive windows during development.MethodsWe examine social behavior during adolescence using a translational mouse model of NMDAR hypofunction (SR-/-) caused by knocking out serine racemase (SR), the enzyme needed to make D-serine, a key NMDAR coagonist. Species-typical social interactions are maintained through brain-wide neural activation patterns; therefore, we employed whole-brain cFos activity mapping to examine network-level connectivity changes caused by SR deletion.ResultsIn adolescent SR-/- mice, we observed disinhibited social behavior toward a novel conspecific and rapid social habituation toward familiar social partners. SR-/- mice also spent more time in the open arm of the elevated plus maze which classically points to an anxiolytic behavioral phenotype. These behavioral findings point to a generalized reduction in anxiety-like behavior in both social and non-social contexts in SR-/- mice; importantly, these findings were not associated with diminished working memory. Inter-regional patterns of cFos activation revealed greater connectivity and network density in SR-/- mice compared to controls.DiscussionThese results suggest that NMDAR hypofunction – a potential biomarker for NDDs – can lead to generalized behavioral disinhibition in adolescence, potentially arising from disrupted communication between and within salience and default mode networks.
Baseline monocyte count predicts symptom improvement during intravenous ketamine therapy in treatment-resistant depression: a single-arm open-label observational study
Authors: Pedraz-Petrozzi Bruno , Spangemacher Moritz , Deicher Anton , Drews Lena , Defert Julie , Silva-Colmenero Ana Yaiza , Wein Paul , Riedinger Elena , Gründer Gerhard , Gilles Maria , Sartorius Alexander , Reinwald Jonathan R. 
Published: June 2024

BackgroundNeuroinflammatory processes in depression are associated with treatment resistance to conventional antidepressants. Ketamine is an effective new therapeutic option for treatment-resistant depression (TRD). Its well-established immunomodulatory properties are hypothesized to mediate its antidepressant effect. In this context, higher levels of inflammation may predict a better treatment response. However, conclusive evidence for this hypothesis is lacking. We thus investigated whether standard peripheral inflammatory cell markers and C-reactive protein (CRP) levels could predict symptom improvement during intravenous ketamine therapy in TRD patients.Methods27 participants with TRD were treated with six weight-adjusted intravenous ketamine infusions (0.5 mg/kg bodyweight) over three weeks. Baseline assessments included CRP, absolute monocyte count (AMC), and absolute neutrophil count (ANC). Depression severity was measured using the Montgomery-Åsberg Depression Rating Scale (MADRS) at baseline (D1), after the first (D3) and before the last ketamine infusion (D18). Raters were blinded for the baseline laboratory assessments.Results13 participants responded to ketamine treatment, and 8 participants partially responded. Baseline AMC showed a strong negative correlation with MADRS change at D3 (r=-0.57, p=0.002) and at D18 (r =-0.48, p=0.010), indicating that a high baseline AMC was associated with greater symptom improvement. A generalized linear model confirmed the association of baseline AMC with symptom improvement during ketamine treatment when additionally accounting for age, sex, and body mass index. Specifically, baseline AMC demonstrated predictive value to discriminate responders and partial responders from non-responders, but lacked discriminative ability between partial responders and responders. Baseline ANC correlated with the MADRS changes at D3 (r=-0.39, p=0.046), while CRP values did not correlate at all.ConclusionsOur prospective single-arm open-label observational study demonstrated that baseline AMC reliably predicted symptom improvement during intravenous ketamine treatment in TRD patients. AMC could therefore serve as a simple and easily accessible marker for symptom improvement during ketamine therapy in daily clinical practice. Future studies with larger sample sizes and a more detailed longitudinal assessment of AMC subtypes are needed to better understand the specific relationship between monocytes and the neuromodulatory effects of ketamine.
Concurrent Validity and Inter-Rater Reliability Assessment of Two Mental Toughness Instruments in Firefighting: A Two-Wave Longitudinal Study
Authors: Stamatis Andreas , Papadakis Zacharias , Beitia Peter 
Published: June 2024

Mental toughness (MT), a construct linked to high-stress performance, is predominantly studied via self-assessment in cross-sectional designs. In the firefighting context, where no dedicated MT instrument exists, the Sports Mental Toughness Questionnaire (SMTQ) and the Military Training Mental Toughness Inventory (MTMTI) have been used. However, their reliability and concurrent validity remain unexamined. This study employs a two-wave longitudinal design involving sixty-two male firefighters. Over two days, they completed the SMTQ, while colleagues and officers assessed their MT using the MTMTI. Analyses included concurrent validity and inter-rater reliability tests. Inter-rater reliability exhibited minimal agreement (Day 1: κ = 0.04, p = 0.172; Day 2: κ = 0.05, p = 0.063), low internal consistency (Day 1: α = 0.03, ω = 0.03; Day 2: α = 0.45, ω = 0.45), and weak inter-rater correlations (Day 1: ICC2k < 0.001, 95%CI [−0.53, 0.35]; Day 2: ICC2k = 0.13, 95%CI [−0.33, 0.43]). Concurrent validity showed limited correlations between self-assessed SMTQ scores and MTMTI ratings on both days (Day 1: r = −0.09, p = 0.5; Day 2: r = 0.1, p = 0.5). These findings may underscore the necessity to develop firefighting-specific MT tools, recognizing the unique demands and nuances of this high-stress profession.
Quality of life assessment in children with dental arch constriction and impaired nasal breathing
Authors: Arutyunyan L. I. , Danilova M. A. , Prokoshev P. A. 
Published: June 2024

Relevance. Malocclusion often cause morphofunctional and aesthetic disturbances in the dentoalveolar system, and the lack of nasal breathing in children exacerbates existing deviations.Purpose. To assess morphofunctional parameters and quality of life indicators in children with impaired nasal breathing.Materials and methods. Photometric facial analysis, cephalometric and anthropometric calculations, anterior active rhinomanometry, and an oral health-related quality of life questionnaire for children (OHRQoL) were conducted.Results. In patients with impaired nasal breathing, social and family well-being parameters were reduced in the quality of life assessment.Conclusion. An orthodontist can determine the causes and degree of nasal breathing impairment by analyzing teleradiographs, orthopantomograms, and studying the quality of life in children. This aids in interdisciplinary planning for early diagnosis and treatment of children with maxillary constriction.
Diverticulitis: una patología que aumenta con la edad
Authors: Navarro Alvarado María José 
Published: June 2024

La diverticulitis se encuentra como uno de los principales diagnósticos diferenciales en pacientes que se presentan con dolor en el cuadrante inferior izquierdo del abdomen. En efecto, no es nada despreciable su prevalencia en personas mayores. Una influencia importante se ha descrito con la alimentación. De hecho, es por esto que es una de las principales razones de mayor impacto en la población occidental. Otros factores importantes descritos son la disminución en la distención del colon sigmoides, aumento de presión intraluminal y factores como el tabaco, obesidad y genéticos. Por su parte, desde los años 70s se describe la importancia del consumo de fibra como factor beneficioso. La clínica asociada a estudios de imagen son trascendentales para su clasificación y posteriormente poder brindar un manejo adecuado. De ellas, Hinchey es la clasificación más comúnmente utilizada. Por otro lado, dentro de las opciones terapéuticas se establece la antibioticoterapia, drenaje percutáneo y cirugía. La gran mayoría de pacientes no complicados se manejan de manera ambulatoria. Sin embargo, aquellos con complicaciones podrían ser candidatos a procedimientos más invasivos, de los cuales el más conocido es el procedimiento de Hartmann.
Strategi Pengembangan Kampung Warna-Warni Teluk Seribu Balikpapan Berdasarkan Sapta Pesona Dalam Meningkatkan Kunjungan Wisatawan
Authors: Alifa Irvisya , Nugroho Rizky Arif , Syafitri Elin Diyah , Dewanti Ajeng Nugrahaning 
Published: June 2024

Berdasarkan RTRW dan RPJMD Kota Balikpapan salah satu objek wisata yang menjadi fokus pengembangan pariwisata adalah Kampung Warna-Warni Teluk Seribu Balikpapan. Sapta Pesona merupakan unsur tolak ukur peningkatan kualitas produk pariwisata yang terdiri dari tujuh unsur yaitu, Keamanan, Ketertiban, Kebersihan, Kesejukan, Keindahan, Keramahan, dan Kenangan. Penggunaan konsep Sapta Pesona diharapkan dapat memberikan pengetahuan kepada wisatawan dan masyarakat sekitar agar lebih sadar wisata serta mengembangkan daya tarik baru kepada wisatawan Kampung Warna-Warni Teluk Seribu sehingga menjadi pariwisata berkelanjutan. Sehingga tujuan dari penelitian ini adalah untuk merumuskan strategi pengembangan Kampung Warna-Warni Teluk Seribu Balikpapan berdasarkan Sapta Pesona dalam meningkatkan kunjungan wisatawan. Dalam mencapai tujuan tersebut maka dirumuskan strategi pengembangan Kampung warna-Warni Teluk Seribu Balikpapan berdasarkan Sapta Pesona dengan analisis komparatif kepada 6 sub variabel yang menjadi prioritas pengembangan, yaitu Penyediaan Informasi Keamanan & Keselamatan, Penyediaan Sistem Keamanan, Ketertiban Peraturan, Pengelolaan Kebersihan, Keindahan Lokasi Wisata, dan Kenangan Atraksi Wisata. Perumusan strategi pengembangan ini dilakukan dengan mengkomparasikan kondisi eksisting dengan Best Practice terkait masing-masing sub variabel.
Analisis Hotspot (Getis Ord Gi*) Pola Spasial Frekuensi Kecelakaan Lalu Lintas di Kota Balikpapan
Authors: Simanungkalit Maylani Angelina , Hidayat Arief , Nugroho Rizky Arif , Depari Andi Sahputra 
Published: June 2024

Transportasi adalah elemen utama dalam pembangunan kota dan ekonomi, namun pertumbuhan pesat transportasi dan kompleksitas masalahnya menciptakan kebutuhan mendesak akan solusi efektif, terutama terkait kecelakaan lalu lintas yang signifikan di Indonesia, termasuk di Kota Balikpapan. Studi ini bertujuan untuk menganalisis pola spasial kecelakaan lalu lintas di Balikpapan menggunakan metode Getis-Ord Gi* untuk mengidentifikasi area dengan frekuensi kecelakaan tinggi (hotspot) dan rendah (coldspot). Data sekunder dari berbagai sumber digunakan dalam analisis ini. Dengan pemodelan spasial menggunakan ArcGIS, hasil menunjukkan bahwa hotspot kecelakaan tertinggi berada di Kecamatan Balikpapan Utara bagian Barat, Balikpapan Kota, Balikpapan Tengah, dan Balikpapan Selatan. Temuan ini diharapkan dapat membantu dalam merancang strategi pencegahan kecelakaan yang lebih efektif untuk meningkatkan keselamatan jalan di Kota Balikpapan.

Kata-kunci : ArcGIS, kecelakaan lalu lintas, Getis-Ord Gi*, hotspot, pola spasial