bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward Flash Flood Modeling Using Gradient Resolving Representative Hillslopes
Authors: Manoj J Ashish , Loritz Ralf , Villinger Franziska , Mälicke Mirko , Koopaeidar Mehdi , Göppert Hans , Zehe Erwin 
Published: June 2024

AbstractIt is increasingly acknowledged that the acceleration of the global water cycle, largely driven by anthropogenic climate change, has a disproportionate impact on sub‐daily and small‐scale hydrological extreme events such as flash floods. These events occur thereby at local scales within minutes to hours, typically in response to high‐intensity rainfall events associated with convective storms. In the present work, we show that by employing physically based representative hillslope models that resolve the main gradients controlling overland flow hydrology and hydraulics, we can get reliable simulations of flash flood response in small data‐scarce catchments. To this end, we use climate reanalysis products and transfer soil parameters previously obtained for hydrological predictions in an experimental catchment in the same landscape. The inverted mass balance of flood reservoirs downstream is employed for model evaluation in these nearly ungauged basins. We show that our approach using representative hillslopes and climate data sets can provide reasonable uncalibrated estimates of the overland runoff response (flood magnitude, storm volume, and event runoff coefficients) in three of the four catchments considered. Given that flash floods typically occur at scales of a few km2 and in ungauged places, our results have implications for operational flash flood forecasting and open new avenues for using gradient resolving physically based models for the design of small and medium flood retention basins around the world.
Plant Morphology Impacts Bedload Sediment Transport
Authors: Liu Chao , Shan Yuqi , He Li , Li Fujian , Liu Xingnian , Nepf Heidi 
Published: June 2024

AbstractBedload sediment transport plays an important role in the evolution of rivers, marshes and deltas. In these aquatic environments, vegetation is widespread, and plant species have unique morphology. However, the impact of real plant morphology on flow and sediment transport has not been quantified. This study used model plants with real plant morphology, based on the aquatic species Phragmites australis, Acorus calamus and Typha latifolia. The frontal area of these species increases away from the bed, which leads to higher near‐bed velocity than would be predicted from depth‐average frontal area. A plant morphology coefficient was defined to quantify the impact of vertically‐varied plant frontal area. Laboratory experiments confirmed that the plant morphology coefficient improved the prediction of near‐bed velocity, near‐bed turbulent kinetic energy and bedload transport rate in canopies with realistic morphology. Plant morphology can alter transport rates by up to an order of magnitude, relative to the assumption of uniform morphology.
Plate‐Scale Imaging of Eastern US Reveals Ancient and Ongoing Continental Deformation
Authors: Brunsvik Brennan , Eilon Zachary , Lynner Colton 
Published: June 2024

AbstractEastern North America was constructed over several Wilson cycles, culminating in the breakup of Pangea. Previous seismological imaging lacked the resolution to depict precisely how ancient tectonic boundaries manifest throughout the lithosphere, how continental breakup modified the plate, or how ongoing mantle dynamics shapes the continental margin. We present a high‐resolution, plate‐scale seismic tomography model of the eastern US by combining an unprecedented suite of complementary data sets in a Bayesian framework. These data provide detailed resolution from crust to asthenosphere, identifying the base of the lithosphere and mid‐lithospheric discontinuities. The plate thins in steps that align with ancient orogens. The lithospheric step at the Appalachian front is associated with cells of mantle upwellings, likely edge‐driven convection, that erode the base of the plate and shape modern Appalachian topography. Low‐velocity structures in the lithospheric‐mantle align with the Grenville front and may be remnants of Rodinia assembly.
Sinuous Aurora at Mars: A Link to the Tail Current Sheet?
Authors: Lillis Robert J. , Deighan Justin , Chirakkil Krishnaprasad , Jain Sonal , Fillingim Matthew , Chaffin Michael , Holsclaw Greg , Susarla Raghuram , Brain David , Al Matroushi Hessa , Lootah Fatma , Al Mazmi Hoor , Dong Yaxue , Schneider Nick , Azari Abigail , Ramstad Robin , Nauth Murti , Ma Yingjuan , Halekas Jasper , Espley Jared , Curry Shannon 
Published: June 2024

AbstractWe examine the newly discovered phenomena of sinuous aurora on the nightside of Mars, using images of 130.4 and 135.6 nm oxygen emission measured by the Emirates Mars Mission EMUS ultraviolet spectrograph, and upstream measurements from the MAVEN and Mars Express spacecraft. They are detected in ∼3% of observations, totaling 73 clear detections. These emissions are narrow, elongated (1,000–6,000 km), cross Mars' UV terminator, and are oriented generally toward the anti‐solar point, clustering into north, south, east, and west‐oriented groups. Diverse morphologies are observed, though some spatial features, such as broad curves, may in some cases be due to temporal aliasing of aurora motion as each image is built up over 15–20 min. Sinuous aurora form away from Mars' strongest crustal magnetic fields and can be interrupted by moderate crustal fields. Sinuous aurora occurrence increases strongly with solar wind pressure, though brightness shows only a weak positive dependence on pressure. Interplanetary magnetic field (IMF) clock angle affects their occurrence and orientation: sinuous aurora show a broad range of orientations centered on the solar wind convection electric field (Econv) direction and forming in the +Econv hemisphere, although with moderate clockwise and counterclockwise average “twists” for westward and eastward IMF, respectively. From these features we infer a link between sinuous aurora and electron energization in Mars' magnetotail current sheet, where field geometry on the +Econv side of the sheet is more organized and symmetric. Determination of specific triggering conditions for sinuous aurora requires further investigation.
Investigating the Hot Zone Developed Under Short‐Circuiting Conditions and the Coupled Magnetosphere‐Ionosphere (M‐I) System for the Subauroral Arc's Inner‐Magnetosphere Generation Environment
Authors: Horvath Ildiko , Lovell Brian C. 
Published: June 2024

AbstractBased on correlated magnetosphere‐ionosphere (M‐I) conjugate observations of seven events, we study the hot zone developed under short‐circuiting conditions leading (a) to the development of outward Subauroral Polarization Streams (SAPS) or Subauroral Ion Drifts (SAID) electric (E) field and (b) to the various subauroral arcs' absence or presence. Results show (a) the close relations of the hot zone earthward extent and peak ion temperature (Ti) to the magnitude of outward SAPS/SAID E field and (b) the hot zone's high Ti (∼11,000 eV) developed under enhanced plasma turbulence that was (c) generated by the amplified narrow hot ion and electron plasma density peaks, (d) sometimes in plasmaspheric plumes, and that was (e) sometimes further enhanced by the strong auroral kilometric radiation (AKR) waves (f) leading to the development of enhanced SAPS/SAID E field. From these (a–f) findings we conclude for the seven events investigated that (a) the hot zone's development under short‐circuiting conditions was regulated by the kinetic energy of mesoscale plasma flows and that (b) the hot zone created the favorable inner‐magnetosphere conditions during short circuiting (c) for stable auroral red (SAR) arc development by plasma turbulence, which is the common source of heat/suprathermal particles accelerated downward, and (d) in the plasmaspheric plume scenario for SAR arc and Strong Thermal Emission Velocity Enhancement (STEVE) arc development by the plumes' enhanced cold plasma populations leading to strong shear flows and thus shear‐flow instabilities well‐known associated with the SAPS/SAR arc and recently regarded as a potential driver mechanism of the STEVE arc.
Advances in fetal and neonatal neuroimaging and everyday exposures
Authors: Lautarescu Alexandra , Bonthrone Alexandra F. , Bos Brendan , Barratt Ben , Counsell Serena J. 
Published: June 2024

Abstract
The complex, tightly regulated process of prenatal brain development may be adversely affected by “everyday exposures” such as stress and environmental pollutants. Researchers are only just beginning to understand the neural sequelae of such exposures, with advances in fetal and neonatal neuroimaging elucidating structural, microstructural, and functional correlates in the developing brain. This narrative review discusses the wide-ranging literature investigating the influence of parental stress on fetal and neonatal brain development as well as emerging literature assessing the impact of exposure to environmental toxicants such as lead and air pollution. These ‘everyday exposures’ can co-occur with other stressors such as social and financial deprivation, and therefore we include a brief discussion of neuroimaging studies assessing the effect of social disadvantage. Increased exposure to prenatal stressors is associated with alterations in the brain structure, microstructure and function, with some evidence these associations are moderated by factors such as infant sex. However, most studies examine only single exposures and the literature on the relationship between in utero exposure to pollutants and fetal or neonatal brain development is sparse. Large cohort studies are required that include evaluation of multiple co-occurring exposures in order to fully characterize their impact on early brain development.

Impact

Increased prenatal exposure to parental stress and is associated with altered functional, macro and microstructural fetal and neonatal brain development.

Exposure to air pollution and lead may also alter brain development in the fetal and neonatal period.

Further research is needed to investigate the effect of multiple co-occurring exposures, including stress, environmental toxicants, and socioeconomic deprivation on early brain development.
DUSP22 inhibits lung tumorigenesis by suppression of EGFR/c-Met signaling
Authors: Lin Hsiao-Han , Chang Cheng-Wei , Liao Yu-Ting , Yeh Shauh-Der , Lin Hsiu-Ping , Ho Hui-Min , Cheung Chantal Hoi-Yin , Juan Hsueh-Fen , Chen Yi-Rong , Su Yu-Wen , Chen Li-Mei , Tan Tse-Hua , Lin Wen-Jye 
Published: June 2024

AbstractDUSP22, an atypical dual-specificity phosphatase enzyme, plays a significant role in regulating multiple kinase signaling pathways by dephosphorylation. Our study demonstrated that decreased DUSP22 expression is associated with shorter disease-free survival, advanced TNM (tumor, lymph nodes, and metastasis), cancer stage, and higher tumor grade in lung adenocarcinoma (LUAD) patients. Exogenous DUSP22 expression reduces the colony-forming capacity of lung cancer cells and inhibits xenograft tumor growth primarily by targeting EGFR and suppressing its activity through dephosphorylation. Knockdown of DUSP22 using shRNA enhances EGFR dependency in HCC827 lung cancer cells and increases sensitivity to gefitinib, an EGFR inhibitor. Consistently, genetic deletion of DUSP22 enhances EGFRdel (exon 19 deletion)-driven lung tumorigenesis and elevates EGFR activity. Pharmacological inhibition of DUSP22 activates EGFR, ERK1/2, and upregulates downstream PD-L1 expression. Additionally, lentiviral deletion of DUSP22 by shRNA enhances lung cancer cell migration through EGFR/c-Met and PD-L1-dependent pathways. Gefitinib, an EGFR inhibitor, mechanistically suppresses migration induced by DUSP22 deletion and inhibits c-Met activity. Furthermore, cabozantinib, a c-Met inhibitor, reduces migration and attenuates EGFR activation caused by DUSP22 deletion. Collectively, our findings support the hypothesis that loss of DUSP22 function in lung cancer cells confers a survival advantage by augmenting EGFR signaling, leading to increased activation of downstream c-Met, ERK1/2, and PD-L1 axis, ultimately contributing to the progression of advanced lung cancer.
Monitoring ocular disease via optical nanostructures potentially applicable to corneal contact lens products
Authors: AlQattan Bader , Elsherif Mohamed , Alam Fahad , Butt Haider 
Published: June 2024

Abstract
Ocular diseases can cause vision problems or even blindness if they are not detected early. Some ocular diseases generate irregular physical changes in the eye; therefore, reliable diagnostic technology for continuous monitoring of the eye is an unmet clinical need. In this study, a pulsed laser (Nd:YAG) was used to create optical nanostructures on a hydrogel-based commercial contact lens. Simulations were used to determine the spacing of the nanostructures, which were then produced and tested on the lens in ambient humidity and fully hydrated environments. The nanostructures produced a 4° diffraction angle difference in response to the environmental changes. Vision obstruction was considered while designing the nanostructure features on the lens. The curved nanostructures exhibited a series of visible rainbow colors with an average range of 8° under normal room light. A spherical surface was also used to simulate the human eye, and application of a force (curvature change) caused the nanostructure spacing to change, influencing the visible color of the contact lenses. A smartphone camera application was used to measure the progress of ocular diseases by analyzing the RGB color values of the visible color. The nanostructures were also responsive to K+ ion variations in artificial tear fluids, with a 12 mmol L−1 sensitivity, which may allow the detection of ocular ionic strength changes.
Proof of concept for a new sensor to monitor marine litter from space
Authors: Cózar Andrés , Arias Manuel , Suaria Giuseppe , Viejo Josué , Aliani Stefano , Koutroulis Aristeidis , Delaney James , Bonnery Guillaume , Macías Diego , de Vries Robin , Sumerot Romain , Morales-Caselles Carmen , Turiel Antonio , González-Fernández Daniel , Corradi Paolo 
Published: June 2024

AbstractWorldwide, governments are implementing strategies to combat marine litter. However, their effectiveness is largely unknown because we lack tools to systematically monitor marine litter over broad spatio-temporal scales. Metre-sized aggregations of floating debris generated by sea-surface convergence lines have been reported as a reliable target for detection from satellites. Yet, the usefulness of such ephemeral, scattered aggregations as proxy for sustained, large-scale monitoring of marine litter remains an open question for a dedicated Earth-Observation mission. Here, we track this proxy over a series of 300,000 satellite images of the entire Mediterranean Sea. The proxy is mainly related to recent inputs from land-based litter sources. Despite the limitations of in-orbit technology, satellite detections are sufficient to map hot-spots and capture trends, providing an unprecedented source-to-sink view of the marine litter phenomenon. Torrential rains largely control marine litter inputs, while coastal boundary currents and wind-driven surface sweep arise as key drivers for its distribution over the ocean. Satellite-based monitoring proves to be a real game changer for marine litter research and management. Furthermore, the development of an ad-hoc sensor can lower the minimum detectable concentration by one order of magnitude, ensuring operational monitoring, at least for seasonal-to-interannual variability in the mesoscale.
A clade of receptor-like cytoplasmic kinases and 14-3-3 proteins coordinate inositol hexaphosphate accumulation
Authors: Xu Li Lin , Cui Meng Qi , Xu Chen , Zhang Miao Jing , Li Gui Xin , Xu Ji Ming , Wu Xiao Dan , Mao Chuan Zao , Ding Wo Na , Benhamed Moussa , Ding Zhong Jie , Zheng Shao Jian 
Published: June 2024

AbstractInositol hexaphosphate (InsP6) is the major storage form of phosphorus in seeds. Reducing seed InsP6 content is a breeding objective in agriculture, as InsP6 negatively impacts animal nutrition and the environment. Nevertheless, how InsP6 accumulation is regulated remains largely unknown. Here, we identify a clade of receptor-like cytoplasmic kinases (RLCKs), named Inositol Polyphosphate-related Cytoplasmic Kinases 1-6 (IPCK1-IPCK6), deeply involved in InsP6 accumulation. The InsP6 concentration is dramatically reduced in seeds of ipck quadruple (T-4m/C-4m) and quintuple (C-5m) mutants, accompanied with the obviously increase of phosphate (Pi) concentration. The plasma membrane-localized IPCKs recruit IPK1 involved in InsP6 synthesis, and facilitate its binding and activity via phosphorylation of GRF 14-3-3 proteins. IPCKs also recruit IPK2s and PI-PLCs required for InsP4/InsP5 and InsP3 biosynthesis respectively, to form a potential IPCK-GRF-PLC-IPK2-IPK1 complex. Our findings therefore uncover a regulatory mechanism of InsP6 accumulation governed by IPCKs, shedding light on the mechanisms of InsP biosynthesis in eukaryotes.
Brain-state mediated modulation of inter-laminar dependencies in visual cortex
Authors: Das Anirban , Sheffield Alec G. , Nandy Anirvan S. , Jadi Monika P. 
Published: June 2024

AbstractSpatial attention is critical for recognizing behaviorally relevant objects in a cluttered environment. How the deployment of spatial attention aids the hierarchical computations of object recognition remains unclear. We investigated this in the laminar cortical network of visual area V4, an area strongly modulated by attention. We found that deployment of attention strengthened unique dependencies in neural activity across cortical layers. On the other hand, shared dependencies were reduced within the excitatory population of a layer. Surprisingly, attention strengthened unique dependencies within a laminar population. Crucially, these modulation patterns were also observed during successful behavioral outcomes that are thought to be mediated by internal brain state fluctuations. Successful behavioral outcomes were also associated with phases of reduced neural excitability, suggesting a mechanism for enhanced information transfer during optimal states. Our results suggest common computation goals of optimal sensory states that are attained by either task demands or internal fluctuations.
Strain-induced long-range charge-density wave order in the optimally doped Bi2Sr2−xLaxCuO6 superconductor
Authors: Kawasaki Shinji , Tsukuda Nao , Lin Chengtian , Zheng Guo-qing 
Published: June 2024

AbstractThe mechanism of high-temperature superconductivity in copper oxides (cuprate) remains elusive, with the pseudogap phase considered a potential factor. Recent attention has focused on a long-range symmetry-broken charge-density wave (CDW) order in the underdoped regime, induced by strong magnetic fields. Here by 63,65Cu-nuclear magnetic resonance, we report the discovery of a long-range CDW order in the optimally doped Bi2Sr2−xLaxCuO6 superconductor, induced by in-plane strain exceeding ∣ε∣ = 0.15 %, which deliberately breaks the crystal symmetry of the CuO2 plane. We find that compressive/tensile strains reduce superconductivity but enhance CDW, leaving superconductivity to coexist with CDW. The findings show that a long-range CDW order is an underlying hidden order in the pseudogap state, not limited to the underdoped regime, becoming apparent under strain. Our result sheds light on the intertwining of various orders in the cuprates.
Ligand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies
Authors: Lindberg Anton , Murrell Emily , Tong Junchao , Mason N. Scott , Sohn Daniel , Sandell Johan , Ström Peter , Stehouwer Jeffrey S. , Lopresti Brian J. , Viklund Jenny , Svensson Samuel , Mathis Chester A. , Vasdev Neil 
Published: June 2024

AbstractPositron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is helping to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmaceutical has been optimized for imaging non-AD tauopathies. Here we show the properties of analogues of a first-in-class 4R-tau lead, [18F]OXD-2115, using ligand-based design. Over 150 analogues of OXD-2115 were synthesized and screened in post-mortem brain tissue for tau affinity against [3H]OXD-2115, and in silico models were used to predict brain uptake. [18F]OXD-2314 was identified as a selective, high-affinity non-AD tau PET radiotracer with favorable brain uptake, dosimetry, and radiometabolite profiles in rats and non-human primate and is being translated for first-in-human PET studies.
No evidence for ongoing replication on ART in SIV-infected macaques
Authors: Immonen Taina T. , Fennessey Christine M. , Lipkey Leslie , Newman Laura , Macairan Agatha , Bosche Marjorie , Waltz Nora , Del Prete Gregory Q. , Lifson Jeffrey D. , Keele Brandon F. 
Published: June 2024

AbstractThe capacity of HIV-1 to replicate during optimal antiretroviral therapy (ART) is challenging to assess directly. To gain greater sensitivity to detect evolution on ART, we used a nonhuman primate (NHP) model providing precise control over the level of pre-ART evolution and more comprehensive analyses than are possible with clinical samples. We infected 21 rhesus macaques (RMs) with the barcoded virus SIVmac239M and initiated ART early to minimize baseline genetic diversity. RMs were treated for 285–1200 days. We used several tests of molecular evolution to compare 1352 near-full-length (nFL) SIV DNA single genome sequences from PBMCs, lymph nodes, and spleen obtained near the time of ART initiation and those present after long-term ART, none of which showed significant changes to the SIV DNA population during ART in any animal. To investigate the possibility of ongoing replication in unsampled putative tissue sanctuaries during ART, we discontinued treatment in four animals and confirmed that none of the 336 nFL SIV RNA sequences obtained from rebound plasma viremia showed evidence of evolution. The rigorous nature of our analyses reinforced the emerging consensus of a lack of appreciable ongoing replication on effective ART and validates the relevance of this NHP model for cure studies.
Hydrogen peroxide is required for light-induced stomatal opening across different plant species
Authors: Shi Wen , Liu Yue , Zhao Na , Yao Lianmei , Li Jinge , Fan Min , Zhong Bojian , Bai Ming-Yi , Han Chao 
Published: June 2024

AbstractStomatal movement is vital for plants to exchange gases and adaption to terrestrial habitats, which is regulated by environmental and phytohormonal signals. Here, we demonstrate that hydrogen peroxide (H2O2) is required for light-induced stomatal opening. H2O2 accumulates specifically in guard cells even when plants are under unstressed conditions. Reducing H2O2 content through chemical treatments or genetic manipulations results in impaired stomatal opening in response to light. This phenomenon is observed across different plant species, including lycopodium, fern, and monocotyledonous wheat. Additionally, we show that H2O2 induces the nuclear localization of KIN10 protein, the catalytic subunit of plant energy sensor SnRK1. The nuclear-localized KIN10 interacts with and phosphorylates the bZIP transcription factor bZIP30, leading to the formation of a heterodimer between bZIP30 and BRASSINAZOLE-RESISTANT1 (BZR1), the master regulator of brassinosteroid signaling. This heterodimer complex activates the expression of amylase, which enables guard cell starch degradation and promotes stomatal opening. Overall, these findings suggest that H2O2 plays a critical role in light-induced stomatal opening across different plant species.