bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kartogenin Induces Chondrogenesis in Cartilage Progenitor Cells and Attenuates Cell Hypertrophy in Marrow-Derived Stromal Cells
Authors: Yang Daniel S. , Trivedi Jay , Betensky Daniel , Desai Salomi , Owens Brett D. , Jayasuriya Chathuraka T. 
Published: May 2024

Introduction:
Kartogenin (KGN) is a synthetic small molecule that stimulates chondrogenic
cellular differentiation by activating smad-4/5 pathways. KGN has been proposed as a feasible
alternative to expensive biologic growth factors, such as transforming growth factor β, which
remain under strict regulatory scrutiny when it comes to use in patients.

Method:
This study reports the previously unexplored effects of KGN stimulation on cartilage-
derived mesenchymal progenitor cells (CPCs), which have been shown to be effective in applications
of cell-based musculoskeletal tissue regeneration. Our findings demonstrate that KGN
treatment significantly increased markers of chondrogenesis, SOX9 and COL2 following 3-10
days of treatment in human CPCs.

Result:
KGN treatment also resulted in a significant dose-dependent increase in GAG production
in CPCs. The same efficacy was not observed in human marrow-derived stromal cells (BM-MSCs);
however, KGN significantly reduced mRNA expression of cell hypertrophy markers, COL10
and MMP13, in BM-MSCs. Parallel to these mRNA expression results, KGN led to a significant
decrease in protein levels of MMP-13 both at 0-5 days and 5-10 days following KGN treatment.

Conclusion:
In conclusion, this study demonstrates that KGN can boost the chondrogenicity of
CPCs and inhibit hypertrophic terminal differentiation of BM-MSCs.
PIPR Machine Learning Model: Obesity Impact Analysis
Authors: Vairachilai Shenbagavel , Periyanayagi Shanmugasundaram , Raja Soosaimarian Peter Raj 
Published: May 2024

Introduction
Obesity is a prevalent and multifaceted health hazard globally, necessitating effective predictive models to mitigate its impact on chronic diseases.

Methods
This paper introduces the Protein Food Item Prediction Regression (PIPR) model, employing machine learning techniques to analyze the influence of protein-rich foods on obesity. The model undergoes rigorous preprocessing and iterative refinement to identify correlated variables and predict obesity trends.

Results
The PIPR model demonstrates superior performance in predicting obesity trends, showcasing lower error rates and high adjusted R2 values. For instance, for the most correlated variables like Meat and Milk (including butter), the model exhibits impressive performance with an MSE of 49.59, RMSE of 7.04, MAE of 5.08, and MAPE of 29%. Similarly, for the least correlated variables like oil crops and vegetable products, the PIPR model maintains excellence with an MSE of 52.51, RMSE of 7.24, MAE of 5.39, and MAPE of 31%.

Conclusion
The PIPR model emerges as a promising tool for understanding and addressing obesity's complexities, offering valuable insights into dietary patterns and potential interventions. Further research and validation could enhance its applicability and effectiveness in combating obesity on a global scale.
Lateral Antrostomy Integrated with Digital Approach (LAIDA): A Case Report and Literature Review
Authors: Speroni Stefano , Rapani Antonio , Zotti Matteo , Miceli Benedetta , Stacchi Claudio 
Published: May 2024

Background
Traditionally, surgeons rely on manual measurements to translate pre-surgical plans into clinical reality during sinus floor elevation with a lateral approach. Standardizing this surgical phase could offer a reproducible technique minimizing operational errors and ensuring more consistent and predictable outcomes.

Objective
This case report presents a comprehensive digital approach integrating lateral antrostomy (LAIDA) for the elevation of the maxillary sinus floor.

Case Presentation
Lateral sinus floor elevation was required for a 61-year-old patient. A detailed digital protocol, integrating artificial intelligence, was employed to create a tooth-supported surgical guide for antrostomy. Under local anaesthesia, a full-thickness flap was elevated to expose the lateral sinus wall. The surgical guide was accurately positioned, and the antrostomy area was marked on the bone wall. The bony window was then performed using round diamond burs, and the Schneiderian membrane was gently lifted until the medial wall of the sinus was exposed. The sub-antral space was filled with a composite graft, and three implants were placed using the same surgical guide. The antrostomy was covered using a resorbable collagen membrane, and flaps were sutured with synthetic monofilament. No intra- and post-operative complications were recorded.

Conclusion
Accurate antrostomy planning and execution are crucial, considering factors, like sinus floor location, presence of alveolar-antral artery, and Underwood septa. The present study emphasizes the benefits of a standardized approach using a 3D-printed surgical guide, aiding real-time visualization of the predetermined bony window during surgery. The LAIDA workflow may help in minimizing intra-operative complications, enhancing patient comfort and improving surgical outcomes.
Improvement of the System of Accounting for Bonuses for Personnel at the Enterprise of the Military-Industrial Complex
Authors: Frolova O. A. , Barinova N. E. 
Published: May 2024

The relevance of the study consists in the need to increase the motivation and efficiency of personnel in the context of a changing economic situation and technological changes at the enterprise of the military-industrial industry.The purpose of the study is to develop a system for accounting for bonuses for personnel on the basis of an updated system of principles for stimulating the activities of employees at the enterprise of the military-industrial complex.The оbjectives: are to develop, on the basis of a comparative analysis of the peculiarities of the industry and the principles of stimulation, a refined system of principles for stimulating the activities of employees; test the method of assessing the performance of employees of scientific, technical and production departments; develop a regulation on the distribution of the amount of the bonus between employees of the enterprise at the end of the reporting period.The methodology is a qualitative study, including an analysis of the existing system of accounting for personnel bonuses, as well as the introduction of an improved system of accounting for bonuses at the enterprise of the military-industrial complex.Results. The article describes the development of a new model for accounting for bonuses for personnel, adapted specifically for enterprises of the military-industrial complex, taking into account their characteristics and needs, and also contains practical recommendations for improving the system of accounting for bonuses for personnel at enterprises of the military-industrial complex, based on the result of the study.Conclusions. Based on the generalization of the best practices of scientists, in terms of the formation of requirements for the system of incentives for employees, as well as the specifics of the activities of the defense industry, the system of principles for stimulating the activities of employees in defense industry organizations was clarified, which made it possible to reduce staff turnover and achieve the strategic goals of enterprises. Key performance indicators have been proposed and tested to assess the performance of employees, as well as regulations on the distribution of the amount of the bonus between employees of the defense industry enterprise based on the results of the reporting period based on the assessment of the employee's labor contribution, obtained by summing up points on basic bonus indicators and individual motivation indicators, This made it possible to calculate the employee's remuneration in a certain order and establish the procedure for awarding employees of scientific and production divisions.
Mechanism for Assessing Financial Stability to Identify the Risks of Working with Contractors
Authors: Bogomolova I. P. , Trineeva L. T. , Filatova M. V. , Tsukanova K. A. , Zhakhov N. V. 
Published: May 2024

Relevance. The article examines the existing methods of assessing the financial stability of commercial organizations and identifies differences in approaches to assessing the financial stability of production and trade organizations, including those working under a commission agreement and/or agency agreement. A mechanism for assessing the financial stability of a counterparty is proposed, which allows step-by-step: to assess the liquidity of the balance sheet and calculate the payment surplus/shortage; to determine the type of financial stability using various assessment methods; to analyze the indicators of financial stability in dynamics by means of calculating and comparing the corresponding values of the coefficients. The existing methodology for calculating aggregated indicators to determine the type of financial stability of counterparties who are commission agents and/or agents has been clarified.The purpose is develop a financial stability assessment mechanism applicable to determine the risk of nonfulfillment of obligations by counterparties.Objectives: to analyze approaches to the definition of "financial stability"; to identify types of risks when working with counterparties; to classify counterparties according to the degree of risk of default; to propose a methodology for calculating aggregated balance sheet liquidity indicators for resellers, as well as a methodology for calculating aggregated indicators when analyzing the financial stability of resellers.Methodology. A wide range of research methods and theoretical concepts have been used to assess financial stability. The main methods of analysis and synthesis, didactics, coefficient analysis, financial analysis, contributing to a detailed consideration of the research problem.Results. A mechanism for assessing the financial stability of a counterparty is proposed, on the basis of which the types of risks when working with counterparties are determined; the existing methodology for calculating aggregated indicators to determine the type of financial stability of counterparties who are commission agents and/or agents is clarified.Conclusion. The result of the study was the developed mechanism for assessing the financial stability of the counterparty, which is carried out in stages.
Hallucination Rates and Reference Accuracy of ChatGPT and Bard for Systematic Reviews: Comparative Analysis
Authors: Chelli Mikaël , Descamps Jules , Lavoué Vincent , Trojani Christophe , Azar Michel , Deckert Marcel , Raynier Jean-Luc , Clowez Gilles , Boileau Pascal , Ruetsch-Chelli Caroline 
Published: May 2024

Background
Large language models (LLMs) have raised both interest and concern in the academic community. They offer the potential for automating literature search and synthesis for systematic reviews but raise concerns regarding their reliability, as the tendency to generate unsupported (hallucinated) content persist.

Objective
The aim of the study is to assess the performance of LLMs such as ChatGPT and Bard (subsequently rebranded Gemini) to produce references in the context of scientific writing.

Methods
The performance of ChatGPT and Bard in replicating the results of human-conducted systematic reviews was assessed. Using systematic reviews pertaining to shoulder rotator cuff pathology, these LLMs were tested by providing the same inclusion criteria and comparing the results with original systematic review references, serving as gold standards. The study used 3 key performance metrics: recall, precision, and F1-score, alongside the hallucination rate. Papers were considered “hallucinated” if any 2 of the following information were wrong: title, first author, or year of publication.

Results
In total, 11 systematic reviews across 4 fields yielded 33 prompts to LLMs (3 LLMs×11 reviews), with 471 references analyzed. Precision rates for GPT-3.5, GPT-4, and Bard were 9.4% (13/139), 13.4% (16/119), and 0% (0/104) respectively (P<.001). Recall rates were 11.9% (13/109) for GPT-3.5 and 13.7% (15/109) for GPT-4, with Bard failing to retrieve any relevant papers (P<.001). Hallucination rates stood at 39.6% (55/139) for GPT-3.5, 28.6% (34/119) for GPT-4, and 91.4% (95/104) for Bard (P<.001). Further analysis of nonhallucinated papers retrieved by GPT models revealed significant differences in identifying various criteria, such as randomized studies, participant criteria, and intervention criteria. The study also noted the geographical and open-access biases in the papers retrieved by the LLMs.

Conclusions
Given their current performance, it is not recommended for LLMs to be deployed as the primary or exclusive tool for conducting systematic reviews. Any references generated by such models warrant thorough validation by researchers. The high occurrence of hallucinations in LLMs highlights the necessity for refining their training and functionality before confidently using them for rigorous academic purposes.
PASTAGENS AMAZÔNICAS: UMA REVISÃO SOBRE O AVANÇO DA PECUÁRIA SOBRE AS TERRAS AMAZÔNICAS
Authors: Lima Alan Ferreira Leite de , Brito Filho Elilson Gomes de , Campos Milton César Costa , Bondade Bruno Bernardo , Almeida Romária Gomes de , Pinheiro Elyenayra Nogueira , Cavalcante Emanuel da Costa , Oliveira Flavio Pereira 
Published: May 2024

Rondônia possui um dos maiores rebanhos de bovinos do brasil, entretanto maior parte das pastagens encontra-se em algum estágio de degradação do solo, diminuindo assim a capacidade de suporte e consequentemente a taxa de lotação. Objetivo dessa pesquisa é, realizar um estudo bibliográfico sobre influência do manejo das pastagens nos atributos do solo e no acúmulo de biomassa no estado de Rondônia, Brasil. Para o estudo foi realizado um levantamento de dados junto as seguintes bases de dados: Pubmed, Scielo, Lilacs, Science Direct, Google Scholar, relacionados ao tema abordado de forma a discutir, confrontar e estabelecer pontos e lacunas baseando-se na literatura. Pastagens na Amazônia continuam sendo um enorme tabu, pois a curto prazo ainda não é possível observar grandes impactos, porém situações semelhantes já ocorreram em outros ecossistemas, onde houve perda de biodiversidade a curto prazo e a longo prazo prejuízos maiores ainda, portanto é preciso, não frear, mas viabilizar as pastagens na Amazônia, de forma a torna-las economicamente viáveis e ecologicamente corretas, pois economicamente ela também trata-se de uma atividade importante para o setor no país.
POLÍTICAS PÚBLICAS E COMUNIDADES TERAPÊUTICAS DESESENVOLVIMENTO COMO LIBERDADE A PARTIR DA GESTÃO DA VIDA
Authors: Raimundo Gedeão de Oliveira , Cavalcanti Marcus Alexandre , De Miranda Maria Geralda 
Published: May 2024

O objetivo do presente artigo é apresentar a concepção de comunidade terapeutica, suas caracteristicas, regulamentações e atividades que são desenvolvidas em seu interior. Para a nossa reflexão, traremos as contribuições teóricas do economista indiano de Amartya Sen acerca de suas concepções acerca do desenvolvimento social a partir da atribuição de capacidades e da liberdade substantiva dos individuos. Para compreendermos o funcionamento dos mecanismos de gestão dos indivíduos e as práticas e estratégias de controle exercidas no interior das Comunidades Terapeuticas buscaremos apoio no filósofo francês Michel Foucault. Para o desenvolvimento deste trabalho optou-se pela pesquisa bibliográfica e pela pesquisa documental. Trata-se de um artigo caráter bibliográfico e documental. Concluimos que as Comunidades Terapeuticas agem como propulsoras de novos comportamentos, como meio facilitador para mudanças e atitudes, e, ainda, proporcionam um ambiente passível para capacitações, promovendo liberdades para que os individuos tenham uma vida digna.Palavras-chave: Comunidades Terapêuticas, Liberdade, Dependência Química, Biopolítica
COMPREENDENDO A GAMIFICAÇÃO E SEUS ELEMENTOS COMO EXEMPLOS NO SUPORTE AO DOCENTE NAS DIFERENTES MODALIDADES DE ENSINO
Authors: Vasconcelos Bruno Cursino de , Seixas Luma da Rocha , Melo Rosangela Maria de , Melo Filho Ivanildo José de 
Published: May 2024

Este trabalho trata-se de um recorte bibliográfico que tem como propósito compreender a gamificação e seus elementos constituintes como exemplos no suporte aos docentes nas diferentes modalidades de ensino com vistas a elucidar o público docente sobre suas possibilidades e potencialidades em sua prática pedagógica. Para tanto, são apresentados os elementos conceituais sobre a gamificação, na sequencia são detalhados seus elementos constituintes. São apresentadas 09 (nove) investigações que foram experimentadas nas modalidades do ensino médio no contexto da Biologia, Língua Portuguesa e Física. Na Educação Profissional e Tecnológica (EPT) nas áreas de Logística, Administração e Desenvolvimento de Sistemas. No ensino superior no cenário da Pedagogia, Ciência da Computação e Engenharia de Produção. Os resultados aferidos apontam para uma contribuição mútua na aprendizagem tanto pelos docentes no tocante a importância do planejamento e na clareza da definição sobre o tema específico a ser abordado em sua prática, quanto pelos discentes pelo fomento que esse tipo de recurso produz em sua motivação e engajamento das atividades que são propostas.Palavras chave: Gamificação, Elementos, Suporte Docente, Modalidades de Ensino.
BIOPOLITICA E GOVERNAMENTO AMBIENTAL EM TEMPOS DE PANDEMIA DO NOVO CORONAVÍRUS
Authors: Cavalcanti Marcus Alexandre , Tenório Cavalcanti Eliane Cristina 
Published: May 2024

O artigo em tela buscou verificar como as medidas de isolamento social recomendadas pela Organização Mundial da Saúde (OMS), em função da pandemia do novo cornoavirus, impactaram de maneira positiva o meio ambiente. Para compreendermos adequadamente esses impactos, analisaremos a complexidade da pandemia em suas múltiplas dimensões, considerando fatores climáticos, socioeconômicos, políticos, cientificos e culturais que configuram todo o cenário pandemico. Tal análise será conduzida a partir de autores como Edgar Morin, Michel Foucault, Felix Guattari e Enrique Leff. O trabalho possui abordagem qualitativa e envolve levantamento bibliográfico, bem como registros documentais. As análises apontam que as medidas restritivas possibilitaram a produção de princípios ecológicos sustentáveis, maior atenção da sociedade em relação ao meio ambiente, além de promover uma cultura política de conscientização em torno de questões ambientais.
O PENSAMENTO ALGEBRICO: COMPREENSÕES À PRÁTICA PEDAGÓGICA DE PROFESSORES QUE ENSINAM MATEMÁTICA NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL
Authors: Santos Anderson Oramisio , Oliveira Guilherme Saramago 
Published: May 2024

O presente artigo aponta caminhos de como é possível trabalhar a construção do pensamento algébrico com as crianças do Ensino Fundamental, anos iniciais, proposto pela BNCC, no eixo temático Álgebra. Este estudo utilizou a análise documental e pesquisas bibliográficas com teóricos que discutem o tema, levantando os dados referentes à construção do pensamento algébrico no Ensino fundamental anos iniciais e a própria BNCC. Nessa perspectiva foi identificado no corpus do trabalho compreensões a prática pedagógica do professor que ensina Matemática nos anos iniciais do Ensino Fundamental, acerca do Pensamento Algébrico, destacando ainda a indicação e importância dos padrões e regularidades em Early Álgebra, considerando o desenvolvimento do pensamento algébrico como etapa fundamental para o aprendizado da álgebra que coaduna com as indicações da BNCC e aponta para a importância de destacar esse tema na formação de professores.
Bioefficacy of Different Formulations of Chlorantraniliprole 0.53%+Fipronil 0.8% GR Against Yellow Stem Borer of Rice
Authors: Dhanapati Gokul Krishna , Karjee Mrinal , Sarkar Prahlad 
Published: May 2024

The study was conducted during rabi (December, 2020–May, 2021), and kharif (July–December, 2021) at University Instructional Farm, UBKV, Pundibari, Cooch Behar, West Bengal, India with a new combination of insecticides Chlorantraniliprole 0.53% w/w and Fipronil 0.8% w/w GR with different formulations to evaluate the bio-efficacy of these combinations of insecticides against yellow stem borer (Scirpophaga incertulas). In this study three formulations of Chlorantraniliprole 0.53% w/w+Fipronil 0.8% w/w GR @ 5.63 kg ha-1, @ 7.50 kg ha-1 and @ 9.38 kg ha-1 were used and Chlorantraniliprole 0.40% GR @ 1 kg ha-1, Fipronil 0.3% GR @ 25 kg ha-1, Cartap hydrochloride 4% GR @ 18.75 kg ha-1 and untreated control were evaluated against yellow stem borer in rice crop. The result suggested from the present investigation that Chlorantraniliprole 0.53%+Fipronil 0.8% GR @ 7.50–9.38 kg ha-1 was found best and effective as well as at par with each other against rice yellow stem borer. It has been observed that Chlorantraniliprole 0.53%+Fipronil 0.8% GR @ 9.38 kg ha-1 registered good yield, 4.81 t ha-1 and 4.72 t ha-1 which were on par with Chlorantraniliprole 0.53%+Fipronil 0.8% GR @ 7.50 kg ha-1 i.e., 4.79 t ha-1 and 4.70 t ha-1 in two consecutive seasons i.e., rabi, 2020–21 and kharif, 2021 respectively Whereas, Chlorantraniliprole 0.53%+Fipronil 0.8% GR @ 7.50 kg ha-1 found much suitable with effective, safe and favorable cost-benefit ratio. The study also showed that there was no significant difference in density of predators in treated and untreated plots.
Effect of Sugarcane Varieties and Milling Delay Time on Cane Sugar Yield
Authors: Muhtadi Much Misbah , Sitawati Sitawati , Suryanto Agus 
Published: May 2024

The quality of sugarcane decreases after harvesting so that it affects the yield and sugar production. The objective of this study was to determine the decline in sugarcane production and sugar yield in different varieties and milling delay time. This study used a split plot design consisting of three varieties (PS 881; PSJK 922; Bululawang) as the main plot and delay time (0; 2; 4 days) as sub plots with three replications so that 27 experimental units need to be provided. The observation parameters consisted of initial stalk weight, stalk weight after delay time, initial yield per hectare, yield per hectare after delay time, ºbrix, %pol, purity, cane yield and sugar yield. Results show that variety and delay time had an effect on stalk weight loss, juice quality, cane and sugar yield. PS 881 and PSJK 922 varieties showed better juice quality and higher cane and sugar yield compared to Bululawang varieties. Sugarcane with a delay time of up to 4 days showed lower stalk weight, juice quality, cane and sugar yield as compared to no delay time. The loss of stalk weight and yield of sugarcane at 2 days delaying time can reach 9.2% and 12.3% at 4 days delay time. Keywords: Delaying time, Juice quality, Sugarcane, Varieties.