bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conjugation of IL‐33 to Microporous Annealed Particle Scaffolds Enhances Type 2‐Like Immune Responses In Vitro and In Vivo
Authors: Roosa Colleen A. , Lempke Samantha L. , Hannan Riley T. , Nicklow Ethan , Sturek Jeffrey M. , Ewald Sarah E. , Griffin Donald R. 
Published: April 2024

AbstractThe inflammatory foreign body response (FBR) is the main driver of biomaterial implant failure. Current strategies to mitigate the onset of a FBR include modification of the implant surface, release of anti‐inflammatory drugs, and cell‐scale implant porosity. The microporous annealed particle (MAP) scaffold platform is an injectable, porous biomaterial composed of individual microgels, which are annealed in situ to provide a structurally stable scaffold with cell‐scale microporosity. MAP scaffold does not induce a discernible foreign body response in vivo and, therefore, can be used a “blank canvas” for biomaterial‐mediated immunomodulation. Damage associated molecular patterns (DAMPs), such as IL‐33, are potent regulators of type 2 immunity that play an important role in tissue repair. In this manuscript, IL‐33 is conjugated to the microgel building‐blocks of MAP scaffold to generate a bioactive material (IL33‐MAP) capable of stimulating macrophages in vitro via a ST‐2 receptor dependent pathway and modulating immune cell recruitment to the implant site in vivo, which indicates an upregulation of a type 2‐like immune response and downregulation of a type 1‐like immune response.
Computational Fluid Dynamics (CFD) Analysis of Bioprinting
Authors: Fareez Umar Naseef Mohamed , Naqvi Syed Ali Arsal , Mahmud Makame , Temirel Mikail 
Published: April 2024

AbstractRegenerative medicine has evolved with the rise of tissue engineering due to advancements in healthcare and technology. In recent years, bioprinting has been an upcoming approach to traditional tissue engineering practices, through the fabrication of functional tissue by its layer‐by‐layer deposition process. This overcomes challenges such as irregular cell distribution and limited cell density, and it can potentially address organ shortages, increasing transplant options. Bioprinting fully functional organs is a long stretch but the advancement is rapidly growing due to its precision and compatibility with complex geometries. Computational Fluid Dynamics (CFD), a carestone of computer‐aided engineering, has been instrumental in assisting bioprinting research and development by cutting costs and saving time. CFD optimizes bioprinting by testing parameters such as shear stress, diffusivity, and cell viability, reducing repetitive experiments and aiding in material selection and bioprinter nozzle design. This review discusses the current application of CFD in bioprinting and its potential to enhance the technology that can contribute to the evolution of regenerative medicine.
Tailoring the Surface Enrichment of a Pt Catalyst in Ionic Liquid Solutions by Choice of the Solvent
Authors: Hemmeter Daniel , Gezmis Afra , Kremitzl Daniel , Wasserscheid Peter , Maier Florian , Steinrück Hans‐Peter 
Published: April 2024

AbstractThe so‐called buoy‐effect, that is, the targeted surface enrichment of a Pt catalyst dissolved in ionic liquids (ILs), is achieved by attaching perfluorinated alkyl chains to the ligand system, which drags the metal complex toward the interface. Using angle‐resolved X‐ray photoelectron spectroscopy, it is demonstrated how this surface enrichment can be tailored by variation of the solvent IL. In [CnC1Im][PF6] ILs (n = 2, 4, 8), the surface is fully saturated with the complex at 10%mol bulk content, while in [C4C1Im][Tf2N] only at 20%mol saturation is observed. At low catalyst concentrations of 1%mol, where saturation is not yet reached, the enrichment increases with decreasing length of the IL alkyl chain. As a general rule, the degree of surface enrichment decreases with the decrease in surface tension of the solvent IL, that is, in the order [C2C1Im][PF6] > [C4C1Im][PF6] > [C8C1Im][PF6] > [C4C1Im][Tf2N]. In ILs with very low surface tension, enrichment is even suppressed. These results reveal the surface tension of the solvent IL as rational parameter for tailoring the interfacial structure of IL‐based catalyst systems, such as supported ionic liquid phase (SILP) catalysis, where the nature of the IL/gas interface is expected to strongly influence the performance of the process.
Conversion of Biopolymer to UV‐Cross‐Linkable Conductive Ink with High Conductivity, Biocompatibility, and Biodegradability
Authors: Jeong Euiseok , Lee Seungae 
Published: April 2024

AbstractBiocompatible, sustainable, and conductive inks are of special interest and are highly valued in the printable bioelectronics. However, the conventional inks, which increase electrical conductivity by mixing metal particles or graphene, can cause long‐term damage when applied to the body and environment. Herein, a method for creating a stable matrix based on a UV‐cross‐linkable polymer to which a conductive polymer can be grafted is investigated to solve the above problems by recycling biomass. Through this, it is possible to achieve high conductivity using only biocompatible and sustainable polymers. Here, conductive inks for printable bioelectronics are developed by grafting polypyrrole on methacrylate‐modified sericin and poly(ethylene glycol) diacrylate (PEGDA). The highest electrical conductivity is achieved by adjusting the ratio of the pyrrole monomers polymerized on each polymer until the conductivity is optimized. Owing to the photoreactive nature of PEGDA, the prepared conductive inks are cross‐linked by UV light, thus giving them easy‐printing properties. The biodegradability, biocompatibility, and electrical properties of the printed patterns are systematically analyzed. This study has significant implications in the field of sustainable and printable bioelectronics as it has developed of a conductive ink with the biocompatibility, biodegradability, and high conductivity that is safer and simpler than conventional methods.
Magnetic Reprogramming of Self‐Assembled Hard‐Magnetic Cilia
Authors: Clary Matthew R. , Cantu Saarah N. , Liu Jessica A.‐C. , Evans Emily E. , Tracy Joseph B. 
Published: April 2024

AbstractArtificial magnetic cilia are hair‐like structures that can respond to magnetic fields. Using hard magnetic materials in magnetic cilia makes possible programming and reprogramming of the magnetization state and corresponding actuation behaviors. Hard‐magnetic cilia are fabricated through self‐assembly by solvent casting of a slurry of NdFeB microparticles dispersed in a solution of a thermoplastic polyurethane elastomer. These hard‐magnetic cilia are capable of attractive and repulsive responses to magnetic fields, determined by the remanent magnetization of the NdFeB microparticles. An array of cilia can be magnetically reprogrammed through immobilization in ice, applying a damped alternating magnetic field first to reduce the remanent magnetization, and then remagnetizing the cilia with a large field. This demagnetization process significantly improves the reprogrammability of the cilia array. Different responses to magnetic fields can be programmed, including spatially nonuniform behaviors. Reprogrammed hard‐magnetic cilia exhibit unique behaviors in rotating magnetic fields. After reprogramming the magnetization direction along the width of the cilia, rotation and torsion cause them to slowly coil and then quickly uncoil in a snapping behavior. Modeling the magnetic and elastic torques during actuation provides additional insights and aids the design of magnetic cilia actuators based on hard magnets.
Hybrid Membrane‐Coated Nanoparticles for Precise Targeting and Synergistic Therapy in Alzheimer's Disease
Authors: Lin Rong‐Rong , Jin Lu‐Lu , Xue Yan‐Yan , Zhang Zhe‐Sheng , Huang Hui‐Feng , Chen Dian‐Fu , Liu Qian , Mao Zheng‐Wei , Wu Zhi‐Ying , Tao Qing‐Qing 
Published: April 2024

AbstractThe blood brain barrier (BBB) limits the application of most therapeutic drugs for neurological diseases (NDs). Hybrid cell membrane‐coated nanoparticles derived from different cell types can mimic the surface properties and functionalities of the source cells, further enhancing their targeting precision and therapeutic efficacy. Neuroinflammation has been increasingly recognized as a critical factor in the pathogenesis of various NDs, especially Alzheimer's disease (AD). In this study, a novel cell membrane coating is designed by hybridizing the membrane from platelets and chemokine (C–C motif) receptor 2 (CCR2) cells are overexpressed to cross the BBB and target neuroinflammatory lesions. Past unsuccessful endeavors in AD drug development underscore the challenge of achieving favorable outcomes when utilizing single‐mechanism drugs.Two drugs with different mechanisms of actions into liposomes are successfully loaded to realize multitargeting treatment. In a transgenic mouse model for familial AD (5xFAD), the administration of these drug‐loaded hybrid cell membrane liposomes results in a significant reduction in amyloid plaque deposition, neuroinflammation, and cognitive impairments. Collectively, the hybrid cell membrane‐coated nanomaterials offer new opportunities for precise drug delivery and disease‐specific targeting, which represent a versatile platform for targeted therapy in AD.
A Soft Collaborative Robot for Contact‐based Intuitive Human Drag Teaching
Authors: Gong Shoulu , Li Wenbo , Wu Jiahao , Feng Bohan , Yi Zhiran , Guo Xinyu , Zhang Wenming , Shao Lei 
Published: April 2024

AbstractSoft material‐based robots, known for their safety and compliance, are expected to play an irreplaceable role in human‐robot collaboration. However, this expectation is far from real industrial applications due to their complex programmability and poor motion precision, brought by the super elasticity and large hysteresis of soft materials. Here, a soft collaborative robot (Soft Co‐bot) with intuitive and easy programming by contact‐based drag teaching, and also with exceptional motion repeatability (< 0.30% of body length) and ultra‐low hysteresis (< 2.0%) is reported. Such an unprecedented capability is achieved by a biomimetic antagonistic design within a pneumatic soft robot, in which cables are threaded to servo motors through tension sensors to form a self‐sensing system, thus providing both precise actuation and dragging‐aware collaboration. Hence, the Soft Co‐bots can be first taught by human drag and then precisely repeat various tasks on their own, such as electronics assembling, machine tool installation, etc. The proposed Soft Co‐bots exhibit a high potential for safe and intuitive human‐robot collaboration in unstructured environments, promoting the immediate practical application of soft robots.
Compositional Analysis of Complex Mixtures using Automatic MicroED Data Collection
Authors: Unge Johan , Lin Jieye , Weaver Sara J , Sae Her Ampon , Gonen Tamir 
Published: April 2024

AbstractQuantitative analysis of complex mixtures, including compounds having similar chemical properties, is demonstrated using an automatic and high throughput approach to microcrystal electron diffraction (MicroED). Compositional analysis of organic and inorganic compounds can be accurately executed without the need of diffraction standards. Additionally, with sufficient statistics, small amounts of compounds in mixtures can be reliably detected. These compounds can be distinguished by their crystal structure properties prior to structure solution. In addition, if the crystals are of good quality, the crystal structures can be generated on the fly, providing a complete analysis of the sample. MicroED is an effective method for analyzing the structural properties of sub‐micron crystals, which are frequently found in small‐molecule powders. By developing and using an automatic and high throughput approach to MicroED, and with the use of SerialEM for data collection, data from thousands of crystals allow sufficient statistics to detect even small amounts of compounds reliably.
Tartronic Acid as a Potential Inhibitor of Pathological Calcium Oxalate Crystallization
Authors: Su Yuan , Li Si , Li Xin , Zhou Jing‐Ying , Chauhan Vraj P. , Li Meng , Su Ya‐Hui , Liu Chun‐Mei , Ren Yi‐Fei , Yin Wu , Rimer Jeffrey D. , Cai Ting 
Published: April 2024

AbstractKidney stones are a pervasive disease with notoriously high recurrence rates that require more effective treatment strategies. Herein, tartronic acid is introduced as an efficient inhibitor of calcium oxalate monohydrate (COM) crystallization, which is the most prevalent constituent of human kidney stones. A combination of in situ experimental techniques and simulations are employed to compare the inhibitory effects of tartronic acid with those of its molecular analogs. Tartronic acid exhibits an affinity for binding to rapidly growing apical surfaces of COM crystals, thus setting it apart from other inhibitors such as citric acid, the current preventative treatment for kidney stones. Bulk crystallization and in situ atomic force microscopy (AFM) measurements confirm the mechanism by which tartronic acid interacts with COM crystal surfaces and inhibits growth. These findings are consistent with in vivo studies that reveal the efficacy of tartronic acid is similar to that of citric acid in mouse models of hyperoxaluria regarding their inhibitory effect on stone formation and alleviating stone‐related physical harm. In summary, these findings highlight the potential of tartronic acid as a promising alternative to citric acid for the management of calcium oxalate nephropathies, offering a new option for clinical intervention in cases of kidney stones.
High‐Entropy Oxides for Rechargeable Batteries
Authors: Ran Biao , Li Huanxin , Cheng Ruiqi , Yang Zhaohui , Zhong Yi , Qin Yonghong , Yang Chao , Fu Chaopeng 
Published: April 2024

AbstractHigh‐entropy oxides (HEOs) have garnered significant attention within the realm of rechargeable batteries owing to their distinctive advantages, which encompass diverse structural attributes, customizable compositions, entropy‐driven stabilization effects, and remarkable superionic conductivity. Despite the brilliance of HEOs in energy conversion and storage applications, there is still lacking a comprehensive review for both entry‐level and experienced researchers, which succinctly encapsulates the present status and the challenges inherent to HEOs, spanning structural features, intrinsic properties, prevalent synthetic methodologies, and diversified applications in rechargeable batteries. Within this review, the endeavor is to distill the structural characteristics, ionic conductivity, and entropy stabilization effects, explore the practical applications of HEOs in the realm of rechargeable batteries (lithium‐ion, sodium‐ion, and lithium‐sulfur batteries), including anode and cathode materials, electrolytes, and electrocatalysts. The review seeks to furnish an overview of the evolving landscape of HEOs‐based cell component materials, shedding light on the progress made and the hurdles encountered, as well as serving as the guidance for HEOs compositions design and optimization strategy to enhance the reversible structural stability, electrical properties, and electrochemical performance of rechargeable batteries in the realm of energy storage and conversion.
Tuning Thermal Conductivity of Hybrid Perovskites through Halide Alloying
Authors: Wang Guang , Fan Hongzhao , Chen Zhongwei , Gao Yufei , Wang Zuankai , Li Zhigang , Lu Haipeng , Zhou Yanguang 
Published: April 2024

AbstractTuning the thermal transport properties of hybrid halide perovskites is critical for their applications in optoelectronics, thermoelectrics, and photovoltaics. Here, an effective strategy is demonstrated to modulate the thermal transport property of hybrid perovskites by halide alloying. A highly tunable thermal conductivity of mixed‐halide hybrid perovskites is achieved due to halide‐alloying and structural distortion. The experimental measurements show that the room temperature thermal conductivity of MAPb(BrxI1‐x)3 (x = 0─1) can be largely modulated from 0.27 ± 0.07 W m−1 K−1 (x = 0.5) to 0.47 ± 0.09 W m−1 K−1 (x = 1). Molecular dynamics simulations further demonstrate that the thermal conductivity reduction of hybrid halide perovskites results from the suppression of the mean free paths of the low‐frequency acoustic and optical phonons. It is found that halide alloying and the induced structural distortion can largely increase the scatterings of optical and acoustic phonons, respectively. The confined diffusion of MA+ cations in the octahedra cage is found to act as an additional thermal transport channel in hybrid perovskites and can contribute around 10–20% of the total thermal conductivity. The findings provide a strategy for tailoring the thermal transport in hybrid halide perovskites, which may largely benefit their related applications.
miR‐146a−/− mice model reveals that NF‐κB inhibition reverts inflammation‐driven myelofibrosis‐like phenotype
Authors: Cuenca‐Zamora Ernesto José , Guijarro‐Carrillo Pedro J. , López‐Poveda María J. , Morales María Luz , Lozano María Luisa , Gonzalez‐Conejero Rocío , Martínez Constantino , Teruel‐Montoya Raúl , Ferrer‐Marín Francisca 
Published: April 2024

AbstractEmerging evidence shows the crucial role of inflammation (particularly NF‐κB pathway) in the development and progression of myelofibrosis (MF), becoming a promising therapeutic target. Furthermore, tailoring treatment with currently available JAK inhibitors (such as ruxolitinib or fedratinib) does not modify the natural history of the disease and has important limitations, including cytopenias. Since recent studies have highlighted the role of miR‐146a, a negative regulator of the NF‐κB pathway, in the pathogenesis of MF; here we used miR‐146a−/− (KO) mice, a MF‐like model lacking driver mutations, to investigate whether pharmacological inhibition of JAK/STAT and/or NF‐κB pathways may reverse the myelofibrotic phenotype of these mice. Specifically, we tested the JAK1/2 inhibitor, ruxolitinib; the NF‐κB inhibitor via IKKα/β, BMS‐345541; both inhibitors in combination; or a dual inhibitor of both pathways (JAK2/IRAK1), pacritinib. Although all treatments decreased spleen size and partially recovered its architecture, only NF‐κB inhibition, either using BMS‐345541 (alone or in combination) or pacritinib, resulted in a reduction of extramedullary hematopoiesis, bone marrow (BM) fibrosis and osteosclerosis, along with an attenuation of the exacerbated inflammatory state (via IL‐1β and TNFα). However, although dual inhibitor improved anemia and reversed thrombocytopenia, the combined therapy worsened anemia by inducing BM hypoplasia. Both therapeutic options reduced NF‐κB and JAK/STAT signaling in a context of JAK2V617F‐driven clonal hematopoiesis. Additionally, combined treatment reduced both COL1A1 and IL‐6 production in an in vitro model mimicking JAK2‐driven fibrosis. In conclusion, NF‐κB inhibition reduces, in vitro and in vivo, disease burden and BM fibrosis, which could provide benefits in myelofibrosis patients.
Comparison of patient‐reported outcomes and clinical characteristics among patients with pituitary macroadenomas and giant adenomas
Authors: Miller Jessa E. , Chung Hye Rhyn , Uy Benjamin R. , Kosaraju Nikitha , Shih Ryan M. , Ko Myungjun , Esswein Shannon R. , Abiri Arash , Khosravi Pooya , Huck Nolan , Nguyen Cecilia H. , Hsu Timothy , Kim Michael G. , Hsu Frank P. K. , Kim Won , Lee Jivianne K. , Suh Jeffrey D. , Bergsneider Marvin , Kuan Edward C. , Wang Marilene B. 
Published: April 2024

Key points
Patients with giant adenomas are more likely to have tumor extension into the paranasal sinuses.
Compared to macroadenomas, giant adenomas are not associated with worse preoperative SNOT‐22 scores.
Japan‐Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial
Authors: Sakurai Takashi , Sugimoto Taiki , Akatsu Hiroyasu , Doi Takehiko , Fujiwara Yoshinori , Hirakawa Akihiro , Kinoshita Fumie , Kuzuya Masafumi , Lee Sangyoon , Matsumoto Nanae , Matsuo Koichiro , Michikawa Makoto , Nakamura Akinori , Ogawa Susumu , Otsuka Rei , Sato Kenji , Shimada Hiroyuki , Suzuki Hiroko , Suzuki Hiroyuki , Takechi Hajime , Takeda Shinya , Uchida Kazuaki , Umegaki Hiroyuki , Wakayama Satomu , Arai Hidenori ,   J‐MINT study group
Published: April 2024

AbstractINTRODUCTIONWe examined the efficacy of a multidomain intervention in preventing cognitive decline among Japanese older adults with mild cognitive impairment (MCI).METHODSParticipants aged 65‐85 years with MCI were randomized into intervention (management of vascular risk factors, exercise, nutritional counseling, and cognitive training) and control groups. The primary outcome was changes in the cognitive composite score over a period of 18 months.RESULTSOf 531 participants, 406 completed the trial. The between‐group difference in composite score changes was 0.047 (95% CI: −0.029 to 0.124). Secondary analyses indicated positive impacts of interventions on several secondary health outcomes. The interventions appeared to be particularly effective for individuals with high attendance during exercise sessions and those with the apolipoprotein E ε4 allele and elevated plasma glial fibrillary acidic protein levels.DISCUSSIONThe multidomain intervention showed no efficacy in preventing cognitive decline. Further research on more efficient strategies and suitable target populations is required.Highlights
This trial evaluated the efficacy of multidomain intervention in individuals with MCI.
The trial did not show a significant difference in preplanned cognitive outcomes.
Interventions had positive effects on a wide range of secondary health outcomes.
Those with adequate adherence or high risk of dementia benefited from interventions.
Dual Redox Reaction Sites for Pseudocapacitance Based on Ti and −P Functional Groups of Ti3C2PBrx MXene
Authors: Zhu Jiamin , Zhu Shengli , Cui Zhenduo , Li Zhaoyang , Wu Shuilin , Xu Wence , Gao Zhonghui , Ba Te , Liang Chunyong , Liang Yanqin , Jiang Hui 
Published: April 2024

AbstractMXenes have extensive applications due to their different properties determined by intrinsic structures and various functional groups. Exploring different functional groups of MXenes leads to improved performance or potential applications. In this work, we prepared new Ti3C2PBrx (x=0.4–0.6) MXene with phosphorus functional groups (−P) through a two‐step gas‐phase reaction. The acquisition of −P is achieved by replacing bromine functional groups (−Br) of Ti3C2Br2 in the phosphorus vapor. After −Br is replaced with −P, Ti3C2PBrx MXene shows an improved areal capacitance (360 mF cm−2) at 20 mV s−1 compared with Ti3C2Br2 MXene (102 mF cm−2). At a current density of 5 mA cm−2 after 10000 cycles, the capacitance retention of Ti3C2PBrx MXene has not decreased. The pseudocapacitive enhancement mechanism has been discovered based on the dual redox sites of the functional groups −P and Ti.