bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cross-sectional study ontrans-fatty acids and risk markers of CHD among middle-aged men representing a broad range of BMI
Authors: Nielsen Birgit M. , Nielsen Marie M. , Jakobsen Marianne U. , Nielsen Carina J. , Holst Claus , Larsen Thomas M. , Bendsen Nathalie T. , Bysted Anette , Leth Torben , Hougaard David M. , Skogstrand Kristin , Astrup Arne , Sørensen Thorkild I. A. , Jess Tine 
Published: May 2011

Intake oftrans-fatty acids (TFA), especially industrially produced TFA (I-TFA), has been associated with the risk of CHD through influence on serum lipid levels. Other causal pathways remain less investigated. In the present cross-sectional study of middle-aged men representing a broad range of BMI, the association between intake of TFA, I-TFA and ruminant TFA (R-TFA) and obesity-associated risk markers of CHD was assessed. The study comprised 393 Danish men (median age 49 years) with a median BMI of 28·4 kg/m2. Intake of TFA was estimated based on 7 d dietary records, whereas outcomes of interest (waist circumference, sagittal abdominal diameter, percentage of truncal fat, C-reactive protein, IL-6, blood lipids, blood pressure, HbA1c and insulin sensitivity index) were obtained through clinical examination. The associations were assessed by linear regression analysis. The median intake of total TFA among the 393 men was 1·3 g/d, covering a daily I-TFA intake of 0·4 g (10–90th percentile 0·0–1·0) and R-TFA intake of 0·9 g (10–90th percentile 0·4–1·8). Intake of these amounts of TFA showed no significant associations with abdominal fatness, inflammatory markers, blood lipids, blood pressure and insulin homeostasis. Among middle-aged men with a generally low intake of TFA, neither I-TFA nor R-TFA was significantly related to obesity-associated risk markers of CHD. The decreased average intake of I-TFA in Denmark since 1995 is suggested to effectively prevent occurrence of the adverse metabolic changes and health consequences, which have formerly been observed in relation to, especially, I-TFA intake.
The efficacy of Phaseolus vulgaris as a weight-loss supplement: a systematic review and meta-analysis of randomised clinical trials
Authors: Onakpoya Igho , Aldaas Salsabil , Terry Rohini , Ernst Edzard 
Published: May 2011

A variety of dietary supplements are presently available as slimming aids, but their efficacy has not been proven. One such slimming aid is the bean extract, Phaseolusvulgaris. The aim of the present systematic review is to evaluate the evidence for or against the efficacy of P. vulgaris. Electronic and non-electronic searches were conducted to identify relevant human randomised clinical trials (RCT). Hand searches of bibliographies were also conducted. No age, time or language restrictions were imposed. The eligibility of studies was determined by two reviewers independently, and the methodological quality of the included studies was assessed. We identified eleven eligible trials, and six were included. All the included RCT had serious methodological flaws. A meta-analysis revealed a statistically non-significant difference in weight loss between P. vulgaris and placebo groups (mean difference (MD) − 1·77 kg, 95 % CI − 3·33, 0·33). A further meta-analysis revealed a statistically significant reduction in body fat favouring P. vulgaris over placebo (MD − 1·86 kg, 95 % CI − 3·39, − 0·32). Heterogeneity was evident in both analyses. The poor quality of the included RCT prevents us from drawing any firm conclusions about the effects of P. vulgaris supplementation on body weight. Larger and more rigorous trials are needed to objectively assess the effects of this herbal supplement.
Gene–PUFA interactions and obesity risk
Authors: Jourdan C. , Kloiber S. , Nieters A. , Seiler H. , Himmerich H. , Kohli M. A. , Lucae S. , Wolfram G. , Gieger C. , Wichmann H.-E. , Linseisen J. 
Published: May 2011

Although there are indications for modulatory effects of PUFA on associations between SNP and obesity risk, scientific evidence in human subjects is still scarce. The present analyses investigated interaction effects between SNP in candidate genes for obesity and PUFA in erythrocyte membranes on obesity risk. Within the second Bavarian Food Consumption Survey (cross-sectional, population-based), 568 adults provided blood samples. Fatty acid composition of erythrocyte membranes was analysed by means of GC. Genotyping was performed for twenty-one genes, including cytokines, adipokines, neurotransmitters and transcription factors. In addition, plasma IL-6 concentrations were analysed. For the statistical analysis, a logistic regression model assuming additive genetic effects was chosen. About 20 % of the study participants were classified as obese (BMI ≥ 30 kg/m2). Several significant gene–PUFA interactions were found, indicating regulatory effects of PUFA by gene variants of IL-2, IL-6, IL-18, TNF receptor family member 1B and 21, leptin receptor and adiponectin on obesity risk. After stratification by genotype, the strongest effects were found for rs2069779 (IL-2) and all tested PUFA as well as for rs1800795 (IL-6) and linoleic or arachidonic acid. The obesity risk of minor allele carriers significantly decreased with increasing fatty acid content. The genetic PUFA–IL-6 interaction was also reflected in plasma IL-6 concentrations. If replicated in a prospective study with sufficient statistical power, the results would indicate a beneficial effect of high PUFA supply for a substantial proportion of the population with respect to obesity risk.
Dietary glycaemic index and glycaemic load among Australian children and adolescents
Authors: Chun Yu Louie Jimmy , Buyken Anette E. , Heyer Kristina , Flood Victoria M. 
Published: May 2011

There are no published data regarding the overall dietary glycaemic index (GI) and glycaemic load (GL) of Australian children and adolescents. We therefore aim to describe the dietary GI and GL of participants of the 2007 Australian National Children's Nutrition and Physical Activity Survey (2007ANCNPAS), and to identify the main foods contributing to their GL. Children, aged 2–16 years, who provided two 24 h recalls in the 2007ANCNPAS were included. A final dataset of 4184 participants was analysed. GI of each food item was assigned using a previously published method. GL was calculated, and food groups contributing to the GL were described by age group and sex. The weighted mean dietary GI and GL of the participants were 54 (sd5) and 136 (sd44), respectively. Among the nutrients examined, Ca had the highest inverse relationship with GI (P < 0·001), while percentage energy from starch was most positively associated with GI. The association between fibre density and GI was modest, and percentage energy from sugar had an inverse relationship with GI. Daily dietary GL contributed by energy-dense and/or nutrient-poor (EDNP) items in subjects aged 14–16 years was more than doubled that of subjects aged 2–3 years. To conclude, Australian children and adolescents were having a high-GI dietary pattern characterised by high-starchy food intake and low Ca intake. A significant proportion of their dietary GL was from EDNP foods. Efforts to reduce dietary GI and GL in children and adolescents should focus on energy-dense starchy foods.
The distribution of SNP marker effects for faecal worm egg count in sheep, and the feasibility of using these markers to predict genetic merit for resistance to worm infections
Authors: KEMPER KATHRYN E. , EMERY DAVID L. , BISHOP STEPHEN C. , ODDY HUTTON , HAYES BENJAMIN J. , DOMINIK SONJA , HENSHALL JOHN M. , GODDARD MICHAEL E. 
Published: May 2011

SummaryGenetic resistance to gastrointestinal worms is a complex trait of great importance in both livestock and humans. In order to gain insights into the genetic architecture of this trait, a mixed breed population of sheep was artificially infected withTrichostrongylus colubriformis(n=3326) and thenHaemonchus contortus(n=2669) to measure faecal worm egg count (WEC). The population was genotyped with the Illumina OvineSNP50 BeadChip and 48 640 single nucleotide polymorphism (SNP) markers passed the quality controls. An independent population of 316 sires of mixed breeds with accurate estimated breeding values for WEC were genotyped for the same SNP to assess the results obtained from the first population. We used principal components from the genomic relationship matrix among genotyped individuals to account for population stratification, and a novel approach to directly account for the sampling error associated with each SNP marker regression. The largest marker effects were estimated to explain an average of 0·48% (T. colubriformis) or 0·08% (H. contortus) of the phenotypic variance in WEC. These effects are small but consistent with results from other complex traits. We also demonstrated that methods which use all markers simultaneously can successfully predict genetic merit for resistance to worms, despite the small effects of individual markers. Correlations of genomic predictions with breeding values of the industry sires reached a maximum of 0·32. We estimate that effective across-breed predictions of genetic merit with multi-breed populations will require an average marker spacing of approximately 10 kbp.
Mapping Mendelian traits in asexual progeny using changes in marker allele frequency
Authors: LOGESWARAN SAYANTHAN , BARTON NICK H. 
Published: May 2011

SummaryLinkage between markers and genes that affect a phenotype of interest may be determined by examining differences in marker allele frequency in the extreme progeny of a cross between two inbred lines. This strategy is usually employed when pooling is used to reduce genotyping costs. When the cross progeny are asexual, the extreme progeny may be selected by multiple generations of asexual reproduction and selection. We analyse this method of measuring phenotype in asexual progeny and examine the changes in marker allele frequency due to selection over many generations. Stochasticity in marker frequency in the selected population arises due to the finite initial population size. We derive the distribution of marker frequency as a result of selection at a single major locus, and show that in order to avoid spurious changes in marker allele frequency in the selected population, the initial population size should be in the low to mid hundreds.
Anterograde–retrograde rendezvous approach for radiation-induced complete upper oesophageal sphincter stenosis: case report and literature review
Authors: Kos M P , David E F , Mahieu H F 
Published: May 2011

AbstractBackground:Strictures of the hypopharynx and oesophagus are frequently observed following (chemo)radiation. Anterograde dilatation of a complete stenosis carries a high risk of perforation. An alternative is described: a combined anterograde–retrograde approach.Case report:A 75-year-old man developed complete stenosis of the oesophageal inlet after primary radiotherapy for laryngeal carcinoma and full percutaneous endoscopic gastrostomy feeding. To prevent creation of a false route into the mediastinum, a dilatation wire was introduced in a retrograde fashion into the oesophagus, through the gastrostomy opening. The wire was endoscopically identified from the proximal side and then passed through a perforation created by CO2 laser. Anterograde dilatation was safely performed, and the patient returned to a normal diet. There is consensus in the literature that blind anterograde dilatation carries a high risk of perforation; therefore, an anterograde–retrograde rendezvous technique is advisable.Conclusion:In cases of complete obstruction of the oesophageal inlet, anterograde–retrograde dilatation represents a safe technique with which to restore enteric continuity.
Site selection ofAcanthochondria cornuta(Copepoda: Chondracanthidae) inPlatichthys flesus(Teleostei: Pleuronectidae)
Authors: CAVALEIRO F. I. , SANTOS M. J. 
Published: May 2011

SUMMARYAcanthochondria cornuta(Copepoda: Chondracanthidae) (N=4841; prevalence: 80·0%; mean±s.d.[range] intensity: 28·8±24·0 [1–110] parasites) infected the branchial chambers of the European flounder,Platichthys flesus(L.), (N=210) according to an established spatial pattern. This was independent of host size. Higher intensities resulted, most frequently, in higher numbers of infection sites, probably due to increased intraspecific competition. Preferential infection of the ocular side was supported by the recorded abundance data and reflected, probably, the fish's bottom-dwelling behaviour. As the parasite develops from one stage into another, it seems to migrate towards different sites: the copepodites and pre-adult females occurred, mainly, in the holobranchs; the adults preferred the internal wall (non-gravid/post-gravid females; adult males) or the pseudobranchs (gravid females). The ventilating water current along with the blood supply are suggested as 2 major factors in determining parasite spatial distribution within the chamber. Parasite crowding in a restricted and narrow space of the posterior region of the internal wall was recorded frequently and resembled that previously reported for the plaice. Differences to other host-parasite systems previously studied should relate with the anatomy of the respiratory apparatus. Bigamous females are reported for the first time.
Précis of O'Keefe & Nadel'sThe hippocampus as a cognitive map
Authors: O'Keefe John , Nadel Lynn 
Published: May 2011

AbstractTheories of spatial cognition are derived from many sources. Psychologists are concerned with determining the features of the mind which, in combination with external inputs, produce our spatialized experience. A review of philosophical and other approaches has convinced us that the brain must come equipped to impose a three-dimensional Euclidean framework on experience – our analysis suggests that object re-identification may require such a framework. We identify this absolute, nonegocentric, spatial framework with a specific neural system centered in the hippocampus.A consideration of the kinds of behaviours in which such a spatial mapping system would be important is followed by an analysis of the anatomy and physiology of this system, with special emphasis on the place-coded neurons recorded in the hippocampus of freely moving rats. A tentative physiological model for the hippocampal cognitive map is proposed. A review of lesion studies, in tasks as diverse as discrimination learning, avoidance, and extinction, shows that the cognitive map notion can adequately explain much of the data.The model is extended to humans by the assumption that spatial maps are built in one hemisphere, semantic maps in the other. The latter provide a semantic deep structure within which discourse comprehension and production can be achieved. Evidence from the study of amnesic patients, briefly reviewed, is consistent with this extension.
Modeling behavioral adaptations
Authors: Clark Colin W. 
Published: May 2011

AbstractOptimization models have often been useful in attempting to understand the adaptive significance of behavioral traits. Originally such models were applied to isolated aspects of behavior, such as foraging, mating, or parental behavior. In reality, organisms live in complex, ever-changing environments, and are simultaneously concerned with many behavioral choices and their consequences. This target article describes a dynamic modeling technique that can be used to analyze behavior in a unified way. The technique has been widely used in behavioral studies of insects, fish, birds, mammals, and other organisms. The models use biologically meaningful parameters and variables, and lead to testable predictions. Limitations arise because nature's complexity always exceeds our modeling capacity.
B-Afferents: A fundamental division of the nervous system mediating homeostasis?
Authors: Prechtl James C. , Powley Terry L. 
Published: May 2011

AbstractThe peripheral nervous system (PNS) has classically been separated into a somatic division composed of both afferent and efferent pathways and an autonomic division containing only efferents. J. N. Langley, who codified this asymmetrical plan at the beginning of the twentieth century, considered different afferents, including visceral ones, as candidates for inclusion in his concept of the “autonomic nervous system” (ANS), but he finally excluded all candidates for lack of any distinguishing histological markers. Langley's classification has been enormously influential in shaping modern ideas about both the structure and the function of the PNS. We survey recent information about the PNS and argue that many of the sensory neurons designated as “visceral” and “somatic” are in fact part of a histologically distinct group of afferents concerned primarily autonomic function. These afferents have traditionally been known as “small dark” neurons or B-neurons. In this target article we outline an association between autonomic and B-neurons based on ontogeny, cell phenotype, and functional relations, grouping them together as part of a common reflex system involved in homeostasis. This more parsimonious classification of the PNS, made possible by the identification of a group of afferents associated primarily with the ANS, avoids a number of confusions produced by the classical orientation. It may also have practical implications for an understanding of nociception, homeostatic reflexes, and the evolution of the nervous system.
Précis ofThe Emperor's New Mind: Concerning computers, minds, and the laws of physics
Authors: Penrose Roger 
Published: May 2011

AbstractThe emperor's new mind(hereafterEmperor) is an attempt to put forward a scientific alternative to the viewpoint of “strong AI,” according to which mental activity is merely the acting out of some algorithmic procedure. John Searle and other thinkers have likewise argued that mere calculation does not, of itself, evoke conscious mental attributes, such as understanding or intentionality, but they are still prepared to accept the action the brain, like that of any other physical object, could in principle be simulated by a computer. InEmperorI go further than this and suggest that the outward manifestations ofconscious mental activity cannot even be properly simulated by calculation. To support this view, I use various arguments to show that the results of mathematical insight, in particular, do not seem to be obtained algorithmically. The main thrust ofthis work, however, is to present an overview ofthe present state of physical understanding and to show that an important gap exists at the point where, quantum and classical physics meet, as well as to speculate on how the conscious brain might be taking advantage ofwhatever new physics is needed to fill this gap to achieve its nonalgorithmic effects.
Rebooting the bootstrap argument: Two puzzles for bootstrap theories of concept development
Authors: Rips Lance J. , Hespos Susan J. 
Published: May 2011

AbstractThe Origin of Concepts sets out an impressive defense of the view that children construct entirely new systems of concepts. We offer here two questions about this theory. First, why doesn't the bootstrapping process provide a pattern for translating between the old and new systems, contradicting their claimed incommensurability? Second, can the bootstrapping process properly distinguish meaning change from belief change?
Oculomotor skill supports the development of object representations
Authors: Schlesinger Matthew , Amso Dima 
Published: May 2011

AbstractAre infants' initial object representations innately specified? We examine the development of perceptual completion in infants by highlighting two issues. First, perceptual completion is supported by neural mechanisms that rely on experience with the environment. Second, we present behavioral and modeling data that demonstrate how perceptual completion can emerge as a consequence of changes in visual attention and oculomotor skill.
Quinian bootstrapping or Fodorian combination? Core and constructed knowledge of number
Authors: Spelke Elizabeth S. 
Published: May 2011

AbstractAccording to Carey (2009), humans construct new concepts by abstracting structural relations among sets of partly unspecified symbols, and then analogically mapping those symbol structures onto the target domain. Using the development of integer concepts as an example, I give reasons to doubt this account and to consider other ways in which language and symbol learning foster conceptual development.
What is the narrow content of fence (and other definitionally and interpretationally primitive concepts)?
Authors: Mandelbaum Eric 
Published: May 2011

AbstractIt's unclear what narrow content is interpersonally shared for concepts that don't originate from core cognition yet are still definitionally and interpretationally primitive. A primary concern is that for these concepts, one cannot draw a principled distinction between inferences that are content determining and those that aren't. The lack of a principled distinction imperils an account of interpersonally shared concepts.
Concept revision is sensitive to changes in category structure, causal history
Authors: Korman Joanna 
Published: May 2011

AbstractCarey argues that the aspects of categorization that are diagnostic of deep conceptual structure and, by extension, narrow conceptual content, must be distinguished from those aspects that are incidental to categorization tasks. For natural kind concepts, discriminating between these two types of processes is complicated by the role of explanatory stance and the causal history of features in determining category structure.
The case for continuity
Authors: Gelman Rochel 
Published: May 2011

AbstractThis article defends a continuity position. Infants can abstract numerosity and young preschool children do respond appropriately to tasks that tap their ability to use a count and cardinal value and/or arithmetic principles. Active use of a nonverbal domain of arithmetic serves to enable the child to find relevant data to build knowledge about the language and use rules of numerosity and quantity.
Concept innateness, concept continuity, and bootstrapping
Authors: Carey Susan 
Published: May 2011

AbstractThe commentators raised issues relevant to all three important theses of The Origin of Concepts (henceforth TOOC). Some questioned the very existence of innate representational primitives, and others questioned my claims about their richness and whether they should be thought of as concepts. Some questioned the existence of conceptual discontinuity in the course of knowledge acquisition and others argued that discontinuity is much more common than was portrayed in TOOC. Some raised issues with my characterization of Quinian bootstrapping, and others questioned the dual factor theory of concepts motivated by my picture of conceptual development.