bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-glycaemic index and -glycaemic load meals increase the availability of tryptophan in healthy volunteers
Authors: Herrera Christopher P. , Smith Keir , Atkinson Fiona , Ruell Patricia , Chow Chin Moi , O'Connor Helen , Brand-Miller Jennie 
Published: February 2011

The purpose of the present study was to determine the influence of the glycaemic index (GI) and glycaemic load (GL) on the ratio of tryptophan (TRP) relative to other large neutral amino acids (LNAA). Ten healthy men (age 22·9 (sd3·4) years; BMI 23·5 (sd1·6) kg/m2) underwent standard GI testing, and later consumed each of a mixed-macronutrient (1915 kJ; 66·5 % carbohydrate (CHO), 17 % protein and 16·5 % fat) high-GI (MHGI), an isoenergetic, mixed-macronutrient low-GI (MLGI) and a CHO-only (3212 kJ; 90 % CHO, 8 % protein, 2 % fat) high-GI (CHGI) meal on separate days. The GI, GL and insulin index values (e.g. area under the curve) were largest after the CHGI meal (117, 200, 158), followed by the MHGI (79, 59, 82) and MLGI (51, 38, 56) meals, respectively (all values were significantly different,P < 0·05). After the MHGI and MLGI meals but not after the CHGI meal, TRP was elevated at 120 and 180 min (P < 0·05). After the CHGI, LNAA was lower compared with the MLGI (P < 0·05); also the rate of decline in LNAA was higher after CHGI compared with MHGI and MLGI (both comparisonsP < 0·05). The percentage increase from baseline in TRP:LNAA after CHGI (23 %) was only marginally higher than after the MHGI meal (17 %;P = 0·38), but it was threefold and nearly significantly greater than MLGI (8 %;P = 0·05). The present study demonstrates that the postprandial rise in TRP:LNAA was increased by additional CHO ingestion and higher GI. Therefore, the meal GL appears to be an important factor influencing the postprandial TRP:LNAA concentration.
The evolution of host specificity in dove body lice
Authors: JOHNSON KEVIN P. , WECKSTEIN JASON D. , BUSH SARAH E. , CLAYTON DALE H. 
Published: February 2011

SUMMARYObjective:Conventional wisdom suggests that parasites evolve increased host specialization over time. Host specificity, which describes the number of host species parasitized, is one aspect of host specialization. Recent studies of vertebrate parasites indicate that highly host-specific parasite lineages are not, in fact, evolutionary dead ends; host generalists can evolve from host specialists.Methods:Using phylogenetic reconstruction methods, we evaluate these patterns in the body lice (Insecta: Phthiraptera) of pigeons and doves, which are permanent ectoparasites that complete their entire life cycle on the body of the host.Results:We find that species of body lice that parasitize more than one species of host (generalists) are invariably derived from lice parasitizing only one species of host (specialists). A previous study of the wing lice of pigeons and doves also found that generalists were derived from specialists, and that these changes were correlated with the presence of a potentially competing species of wing louse on the same host. For body lice we did not find such a correlation with competition. Instead, the evolution of host generalists in body lice was correlated with host ecology. When we compared body lice that parasitize terrestrial versus arboreal hosts, we found that the evolution of host generalists was associated with terrestrial hosts. In contrast, wing lice showed no correlation between the evolution of generalists and host ecology.Conclusion:The correlation in body lice suggests that dispersal between host species may occur via the ground. This, in turn, suggests that body lice may fall to the ground more often than wing lice. To test this hypothesis, we conducted an experiment to compare the rate at which body and wing lice are dislodged from the bodies of preening pigeons. Interestingly, our results showed that body lice are dislodged four times more often than wing lice. Therefore, species of terrestrial doves are far more likely to encounter body lice than wing lice on the ground.
Antiparasitic drugs for paediatrics: systematic review, formulations, pharmacokinetics, safety, efficacy and implications for control
Authors: KEISER JENNIFER , INGRAM KATRIN , UTZINGER JÜRG 
Published: February 2011

SUMMARYDrug development for paediatric applications entails a number of challenges, such as the wide age spectrum covered – from birth to adolescence – and developmental changes in physiology during biological maturation that influence the efficacy and toxicity of drugs. Safe and efficacious antiparasitic drugs for children are of pivotal importance given the large proportion of burden attributable to parasitic diseases in this age group, and growing efforts to administer, as widely as possible, antiparasitic drugs to at-risk populations, such as infants and school-aged children, often without prior diagnosis. The purpose of this review is to investigate whether antiparasitic drugs have been adequately studied for use in paediatrics. We approached this issue through a systematic review using PubMed and the Cochrane Central Register of Trials covering a period of 10 years and 8 months until the end of August 2010 to identify trials that investigated efficacy, safety and pharmacokinetic (PK) parameters of antiparasitic drugs for paediatrics. Overall, 269 clinical drug trials and 17 PK studies met our inclusion criteria. Antimalarial drugs were the most commonly studied medicines (82·6%). Most trials were carried out in Africa and children aged 2–11 years were the age group most often investigated. Additionally, we critically examined available drug formulations for anthelminthics and identified a number of shortcomings that are discussed. Finally, we shed new light on current proposals to expand ‘preventive chemotherapy’ to preschool-aged children and emphasise that new research, including risk-benefit analyses, are needed before such a strategy can be adopted more widely.
General relativistic plasmas around rotating black holes
Authors: Koide Shinji 
Published: February 2011

AbstractWe show one of possible directions of general relativistic MHD (GRMHD) calculations of astrophysical relativistic jet formation. This was motivated by observations of radio knot ejections associated with high energy flares of an AGN in M87 and micro-quasars. We introduce a modified version of a solar flare model for the phenomenon. In the model, we have to consider a process beyond the ideal GRMHD. Especially, we focus on the special features of general relativistic plasmas around rotating black holes.
Variability studies in blazar jets with SF analysis: caveats and problems
Authors: Emmanoulopoulos Dimitrios , McHardy Ian M. , Uttley Phil 
Published: February 2011

AbstractBlazars are radio-loud active galactic nuclei (AGN) dominated by relativistic jets seen at small angles to the line-of-sight. They exhibit dramatic flux variations across the electromagnetic spectrum. The fastest variations are observed in the X-ray and γ-ray bands on time-scales of hours or even minutes. Currently, a substantial part of the blazar literature has been based on the study of these temporal variations through the use of structure function (SF) analysis, the results of which are believed to put great constrains on the jet-physics.The SF is often invoked in the framework of shot-noise models to determine the temporal properties of individual shots within the jet as well as their geometrical sizes. We argue, that for blazar variability studies, the SF-results are sometimes erroneously interpreted leading to misconceptions about the actual source properties. Based on extensive simulations we caution that spurious breaks will appear in the SFs of almost all light-curves, even though these light-curves may contain no intrinsic characteristic time-scale.Finally, it is also commonly thought that SFs are immune to the sampling problems, such as data-gaps, which affects the estimators of the underlying power spectra density function such as the periodogram. However, we show that SFs are also troubled by gaps which can induce artefacts.
The jet in M87 from e-EVN observations
Authors: Giovannini G. , Casadio C. , Giroletti M. , Beilicke M. , Cesarini A. , Krawczynski H. 
Published: February 2011

AbstractOne of the most intriguing open questions of today's astrophysics is the jet physical properties and the location and the mechanisms for the production of MeV, GeV, and TeV gamma-rays in AGN jets. M87 is a privileged laboratory for a detailed study of the properties of jets, owing to its proximity, its massive black hole, and its conspicuous emission at radio wavelengths and above. We started on November 2009 a monitoring program with the e-EVN at 5 GHz. We present here results of these multi-epoch observations and discuss the two episodes of activity at energy E>100 GeV that occured in this period. One of these observations was obtained at the same day of the first high energy flare. We added to our results literature data obtained with the VLBI and VLA. A clear change in the proper motion velocity of HST-1 is present at the epoch ~2005.5. In the time range 1998 – 2005.5 the apparent velocity is subluminal, and superluminal (~2.7c) after 2005.5.
Intermittent activity of radio sources. Accretion instabilities and jet precession.
Authors: Kunert-Bajraszewska M. , Janiuk A. , Siemiginowska A. , Gawroński M. 
Published: February 2011

AbstractWe consider the radiation pressure instability operating on short timescales (103 - 106 years) in the accretion disk around a supermassive black hole as the origin of the intermittent activity of radio sources. We test whether this instability can be responsible for short ages (<104 years) of Compact Steep Spectrum sources measured by hot spots propagation velocities in VLBI observations and statistical overabundance of Gigahertz Peaked Spectrum sources. The implied timescales are consistent with the observed ages of the sources. We aslo discuss possible implications of the intermittent activity on the complex morphology of radio sources, such as the quasar 1045+352, dominated by a knotty jet showing several bends. It is possible that we are whitnessing an ongoing jet precession in this source due to internal instabilities within the jet flow.
Suzaku observations of the radio galaxy Fornax A west lobe
Authors: Seta Hiromi , Tashiro Makoto S. , Isobe Naoki 
Published: February 2011

AbstractWe performed mapping observations of the Fornax A west lobe with Suzaku in order to measure X-ray brightness distribution. Thanks to the low and stable background of Suzaku, we succeeded in detecting the faint diffuse X-ray emission from the west lobe. Performing careful corrections to the obtained images, we finally measured the X-ray brightness profile extending over the lobe. By comparing the X-ray and radio profiles, the magnetic field found to be fairly constant at ~1 μG over the lobe, while the electron energy distribution is suggested to concentrate on the lobe center.
Radio Loud AGN in the 2XMMi catalogue
Authors: Labiano Alvaro , Guainazzi Matteo , Bianchi Stefano 
Published: February 2011

AbstractWe are carrying out a search for all radio loud Active Galactic Nuclei observed with XMM-Newton, including targeted and field sources to perform a multi-wavelength study of these objects. We have cross-correlated the Verón-Cetty & Verón (2010) catalogue with the XMM-Newton Serendipitous Source Catalogue (2XMMi) and found around 4000 sources. A literature search provided radio, optical, and X-ray data for 403 sources. This poster summarizes the first results of our study.
X-ray radiation of the jets and the supercritical accretion disk in SS 433
Authors: Fabrika Sergei , Medvedev Alexei 
Published: February 2011

AbstractThe observed X-ray luminosity of SS 433 is ~1036 erg/s, it is known that all the radiation is formed in the famous SS 433 jets. The bolometric luminosity of SS 433 is ~1040 erg/s, and originally the luminosity must be realized in X-rays. The original radiation is probably thermalized in the supercritical accretion disk wind, however the missing more than four orders of magnitude is surprising. We have analysed the XMM-Newton spectra of SS 433 using a model of adiabatically and radiatively cooling X-ray jets. The multi-temperature thermal jet model reproduces very well the strongest observed emission lines, but it can not reproduce the continuum radiation and some spectral features. We have found a notable contribution of ionized reflection to the spectrum in the energy range from ~3 to 12 keV. The reflected spectrum is an evidence of the supercritical disk funnel, where the illuminating radiation comes from deeper funnel regions, to be further reflected in the outer visible funnel walls (r ≥ 2 ⋅ 1011 cm). The illuminating spectrum is similar to that observed in ULXs, its luminosity has to be no less than ~1039 erg/s. A soft excess has been detected, that does not depend on the thermal jet model details. It may be represented as a BB with a temperature of Tbb ≈ 0.1 keV and luminosity of Lbb~3 ⋅ 1037 erg/s. The soft spectral component has about the same parameters as those found in ULXs.
The disk/jet connection in the enigmatic microquasar Cygnus X-3
Authors: Koljonen Karri I. I. , Hannikainen Diana C. , McCollough Michael L. , Pooley Guy G. , Trushkin Sergei A. , Tavani Marco , Droulans Robert 
Published: February 2011

AbstractSimultaneous multi-wavelength observations are crucial for understanding the physics of microquasars, especially the accretion disk/jet connection. The enigmatic microquasar Cygnus X-3 exhibits strong, relativistic jet ejection events producing radio flares up to 20 Jy. These events are preceded by a very soft X-ray state with quenched emission in the radio and hard X-ray bands. Recently, GeV flux was observed by the AGILE and Fermi γ-ray observatories during the newly-identified hypersoft state. By using an extensive database of simultaneous multi-wavelength observations gathered from Cygnus X-3 we can form a more unified picture of the nature of the source and show how the recent γ-ray observations fit into it.
Is there a mildly relativistic jet in SN2007gr?
Authors: Paragi Z. , van der Horst A. J. , Tanaka M. , Taylor G. B. , Kouveliotou C. , Granot J. , Ramirez-Ruiz E. , Pidopryhora Y. , Bourke S. , Campbell R. M. , Garrett M. A. , van Langevelde H. J. 
Published: February 2011

AbstractSN2007gr was an ordinary type Ic supernova, with a hint of asymmetric explosion seen in the optical polarization spectrum. This type of SNe is occasionally associated with long duration gamma-ray bursts which generate ultra-relativistic jets; no relativistic outflows have yet been found by direct imaging in SNe Ib/c explosions. High resolution very long baseline interferometry (VLBI) data and simultaneous total radio flux density measurements indicated that SN2007gr has expanded mildly relativistically. We performed late time Westerbork Synthesis Radio Telescope (WSRT) observations to measure the level of the underlying extended emission. Comparison of the VLBI and the background-subtracted WSRT and independent VLA data indicate an at least partially resolved source with an average expansion velocity of ≥0.4c, although the VLBI data could be consistent with a fainter source with an expansion velocity of ~0.2c as well.
Afterglow light curves from magnetized GRB flows
Authors: Mimica Petar , Giannios Dimitrios , Aloy Miguel Ángel 
Published: February 2011

AbstractUsing the RMHD code MRGENESIS and the radiative transfer code SPEV we compute multiwavelength afterglow light curves of magnetized ejecta of gamma-ray bursts interacting with a uniform circumburst medium. We are interested in the emission from the reverse shock when ejecta magnetization varies from σ0 = 0 to σ0 = 1. For typical parameters of the ejecta, the emission from the reverse shock peaks for magnetization σ0 ~ 0.01 − 0.1, and is suppressed for higher σ0. We fit the early afterglow light curves of GRB 990123 and 090102 and discuss the possible magnetization of the outflows of these bursts. Finally we discuss the amount energy left in the magnetic field which is available for dissipation at later afterglow stages.
Cosmology and the subclasses of the gamma-ray bursts
Authors: Mészáros Attila , Horváth István , Řípa Jakub , Bagoly Zsolt , Balázs Lajos G. , Veres Péter 
Published: February 2011

AbstractSeveral statistical studies - done also by the authors of this contribution - show that there are three subclasses of gamma-ray bursts. They can be called as short, intermediate and long ones, because they can be separated with respect to their durations. The short and intermediate bursts are distributed anisotropically on the sky. This behavior is highly remarkable, and can have a cardinal impact on the cosmology. The subject of this contribution is a survey of this topic.
VLT/NACO detection of a proplyd/jet candidate in the core of Trumpler 14
Authors: Vicente Sílvia , Alves João , Matsuyama Isamu , Bouy Hervé , Spezzi Loredana , Ascenso Joana , Santos Filipe D. , Prusti Timo 
Published: February 2011

AbstractThis paper reports the discovery and presents the results of a first analysis of the observed morphology of a candidate external irradiated circumstellar disk/jet system found in the deep core of Trumpler 14, a cluster an order of magnitude more massive than the only cluster where bona-fide proplyds have been found, the Trapezium cluster in the Orion Nebula.
Role of Endosomes in Simian Virus 40 Entry and Infection
Authors: Engel Sabrina , Heger Thomas , Mancini Roberta , Herzog Fabian , Kartenbeck Jürgen , Hayer Arnold , Helenius Ari 
Published: February 2011

ABSTRACT
After binding to its cell surface receptor ganglioside GM1, simian virus 40 (SV40) is endocytosed by lipid raft-mediated endocytosis and slowly transported to the endoplasmic reticulum, where partial uncoating occurs. We analyzed the intracellular pathway taken by the virus in HeLa and CV-1 cells by using a targeted small interfering RNA (siRNA) silencing screen, electron microscopy, and live-cell imaging as well as by testing a variety of cellular inhibitors and other perturbants. We found that the virus entered early endosomes, late endosomes, and probably endolysosomes before reaching the endoplasmic reticulum and that this pathway was part of the infectious route. The virus was especially sensitive to a variety of perturbations that inhibited endosome acidification and maturation. Contrary to our previous models, which postulated the passage of the virus through caveolin-rich organelles that we called caveosomes, we conclude that SV40 depends on the classical endocytic pathway for infectious entry.
The Gut Mucosal Viral Reservoir in HIV-Infected Patients Is Not the Major Source of Rebound Plasma Viremia following Interruption of Highly Active Antiretroviral Therapy
Authors: Lerner Paula , Guadalupe Moraima , Donovan Richard , Hung Jason , Flamm Jason , Prindiville Thomas , Sankaran-Walters Sumathi , Syvanen Michael , Wong Joseph K. , George Michael D. , Dandekar Satya 
Published: February 2011

ABSTRACT

Interruption of suppressive highly active antiretroviral therapy (HAART) in HIV-infected patients leads to increased HIV replication and viral rebound in peripheral blood. Effects of therapy interruption on gut-associated lymphoid tissue (GALT) have not been well investigated. We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene expression in GALT of three HIV-positive patients who initiated HAART during primary HIV infection but opted to interrupt therapy thereafter. Longitudinal viral sequence analysis revealed that a stable proviral reservoir was established in GALT during primary HIV infection that persisted through early HAART and post-therapy interruption. Proviral variants in GALT and peripheral blood mononuclear cells (PBMCs) displayed low levels of genomic diversity at all times. A rapid increase in viral loads with a modest decline of CD4
+
T cells in peripheral blood was observed, while gut mucosal CD4
+
T cell loss was severe following HAART interruption. This was accompanied by increased mucosal gene expression regulating interferon (IFN)-mediated antiviral responses and immune activation, a profile similar to those found in HAART-naive HIV-infected patients. Sequence analysis of rebound virus suggested that GALT was not the major contributor to the postinterruption plasma viremia nor were GALT HIV reservoirs rapidly replaced by HIV rebound variants. Our data suggest an early establishment and persistence of viral reservoirs in GALT with minimal diversity. Early detection of and therapy for HIV infection may be beneficial in controlling viral evolution and limiting establishment of diverse viral reservoirs in the mucosal compartment.
Existence and Stability of Solutions for Implicit Multivalued Vector Equilibrium Problems
Authors: Wang Sanhua , Li Qiuying 
Published: February 2011

AbstractA class of implicit multivalued vector equilibrium problems is studied. By using the generalized Fan-Browder fixed point theorem, some existence results of solutions for the implicit multivalued vector equilibrium problems are obtained under some suitable assumptions. Moreover, a stability result of solutions for the implicit multivalued vector equilibrium problems is derived. These results extend and unify some recent results for implicit vector equilibrium problems, multivalued vector variational inequality problems, and vector variational inequality problems.
Comparison of Affirm VPIII and Papanicolaou Tests in the Detection of Infectious Vaginitis
Authors: Levi Angelique W. , Harigopal Malini , Hui Pei , Schofield Kevin , Chhieng David C. 
Published: February 2011

Abstract
To compare the Affirm VPIII molecular test (Becton Dickinson, Burlington, NC) with morphologic identification used in routine Papanicolaou (Pap) test screening in the detection and identification of Candida species, Trichomonas vaginalis, and Gardnerella vaginalis, we identified 431 cases with a concomitant Pap test and Affirm VPIII assay performed from the archives of a large academic institution. The study population consisted of women ranging in age from 17 to 79 years (mean and median ages, 33 and 31 years, respectively). With a routine Pap test, 60 patients (13.9%) were found to have bacterial vaginosis, 60 (13.9%) candidiasis, and 3 (0.7%) Trichomonas infection. With the Affirm VPIII assay, 183 (42.5%) patients tested positive for G vaginalis, 70 (16.2%) positive for Candida species, and 10 (2.3%) positive for T vaginalis. The differences were statistically significant. The results demonstrate that our patient population had a high incidence of bacterial vaginosis/Candida vaginitis; however, the Affirm VPIII was a more sensitive diagnostic test for the detection and identification of all 3 organisms compared with the Pap test.
New Voices in Women's Health: Perceptions of Women With Intellectual and Developmental Disabilities
Authors: Brown Allison A. , Gill Carol J. 
Published: February 2011

Abstract
This study explored aging and health experiences and concerns of women with intellectual and developmental disabilities, using a participatory approach that captured the direct reports of the women, in their own words and from their own perspectives. The results of a qualitative analysis of 6 focus groups, composed of 34 women with intellectual and developmental disabilities, Age 30 years and older are reported. The focus groups addressed health knowledge, body awareness, developmental and age-related changes, life satisfaction, health behaviors, health service experiences, and perceptions of disability. Findings indicated that the women held misconceptions and limited knowledge regarding health and aging. The results are discussed in relation to disability, women's health, and social support issues, including recommendations for health professionals and care providers.