bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Cisplatin-Induced Acute Kidney Injury in Patients Coprescribed Serotonin Receptor Antagonists: A Retrospective Analysis
Authors: Gutgarts Victoria , Gerardine Supriya , Shingarev Roman A. , Knezevic Andrea , Zabor Emily C. , Latcha Sheron , Joy Melanie S. , Aleksunes Lauren M. , Jaimes Edgar A. 
Published: May 2024

Key Points

Serotonin receptor antagonists reduce the incidence of AKI in patients receiving cisplatin as chemotherapy.New-generation serotonin receptors do not offer any additional advantage in terms of protection from cisplatin induced AKI.

Background
Cisplatin is an effective first-line therapy for a variety of cancers. Cisplatin is highly emetogenic and resulting volume depletion can contribute to AKI. Antiemetic drugs, such as 5-hydroxytryptamine type 3 receptor antagonists (5-HT3RAs), are commonly prescribed to prevent this complication. Preclinical studies suggest first-generation 5-HT3RAs may alter the renal clearance and increase cisplatin toxicity. This retrospective study evaluated whether different 5-HT3RAs modify the risk of AKI in patients receiving cisplatin.

Methods
Patients with cancer who received cisplatin between January 1, 2010, and December 31, 2016, were included. Patients older than 18 years with available data for baseline and post-treatment serum creatinine, cisplatin cumulative dose, and administration of 5-HT3RAs, including first-generation (ondansetron, granisetron, and ramosetron) and second-generation (palonosetron), were analyzed. AKI was defined as 1.5× increase in serum creatinine. Fisher exact and Wilcoxon rank-sum tests were used to assess univariable associations between baseline covariates and AKI and logistic regression for multivariable associations with AKI.

Results
Of 8703 patients identified with cisplatin exposure, 6889 were included. A total of 3881 patients (56.3%) received at least one 5-HT3RA, including palonosetron (3750, 54.4%), ondansetron (1399, 20.3%), and granisetron (11, 0.2%). AKI developed in 1666 patients (24.2%) after cisplatin therapy. Patients who received any 5-HT3RAs were less likely to experience AKI as compared with patients who did not (22.6% versus 26.2%, P = 0.001). Older age, male sex, African ethnicity, and cumulative cisplatin dose were univariably associated with higher risk of AKI (P < 0.001). After adjusting for these variables, use of any of these antiemetic drugs was protective for AKI (odds ratio, 0.84; 95% confidence interval, 0.75 to 0.94; P = 0.003) with no difference detected between type of 5-HT3RA.

Conclusions
Nephrotoxicity continues to be a concern after cisplatin therapy. Given its emetogenic nature, use of antiemetic drugs, such as 5-HT3RAs, can lessen emesis and lower risk of kidney injury. This retrospective analysis supports use of any 5-HT3RAs to lower risk of AKI.
Microscopic mechanisms of nitrogen doping in silicon carbide during epitaxial growth
Authors: Yamauchi Souichiro , Mizushima Ichiro , Yoda Takashi , Oshiyama Atsushi , Shiraishi Kenji 
Published: May 2024

Abstract
We report first-principles calculations that unveil elementary processes of nitrogen donor doping during epitaxial growth of silicon carbide (SiC). We find that a N2 molecule adsorbed on the terrace migrates to a particular step edge where under-coordinated Si atoms appear, or is directly adsorbed near the step edge, and then dissociated there via the step-molecule interaction. This results in the N atom being eventually incorporated at the C substitutional site of the step. The calculated energy barriers indicate that the N incorporation reactions at the step edges occur at a typically high temperature in SiC epitaxial growth.
ABORDAGEM DIAGNÓSTICA E TERAPÊUTICA DO ABDOME AGUDO VASCULAR COM ÊNFASE NA ISQUEMIA MESENTÉRICA AGUDA: UMA REVISÃO BIBLIOGRÁFICA.
Authors: Brito Paulo Roberto da Silva , Veras Marina Andrade de Lobão , Gomes Ferlany Araujo Carneiro , Nascimento Anne Dollores Sousa Jardim , Alves Dayara Hellen Sousa , Algarves Ingrid Elouf Askar , Santana Maria Eduarda de Albuquerque , Silva Rafaela Mendes da , Brito Nayla Cristine da Silva 
Published: May 2024

O abdome vascular agudo é uma condição clínica grave que ocorre quando o fluxo sanguíneo para os órgãos abdominais diminui rapidamente, o que pode causar uma isquemia e uma provável necrose tecidual. A isquemia mesentérica aguda (IMA) é uma forma complexa dessa síndrome, caracterizada pela obstrução súbita da circulação arterial ou venosa mesentérica, o que resulta na perfusão indireta do intestino delgado e na isquemia subsequente.Metodologia: A pesquisa foi realizada através do acesso online nas bases de dados científicos como: Google Scholar, National Library of Medicine(PubMed), Biblioteca Virtual em Saúde (BVS) e Scientific Electronic Library Online(SCIELO) para seleção dos artigos, através de palavras-chave presentes nos descritores Abdome Agudo Vascular, Diagnóstico, Isquemia Mesentérica Aguda,Necrose Intestinal., Revascularização , Tratamento. Resultados: é uma condição grave que pode se manifestar de forma súbita, com dor abdominal intensa e desproporcional ao exame físico, podendo evoluir para sinais de peritonismo. Fatores de risco incluem doenças cardíacas e aórticas. O diagnóstico é desafiador e inclui dosagem de lactato sérico, achados laboratoriais como leucocitose e alterações em exames de imagem como radiografia e tomografia de abdome. A angiografia pode ser necessária em casos específicos. O tratamento envolve revascularização mesentérica, cirurgia para remoção de segmentos necróticos e suporte pós-operatório. A morbidade e mortalidade associadas ao IMA são altas, sendo o tempo entre os sintomas e o tratamento um fator crucial no prognóstico. Considerações Finais: IMA é uma condição clínica complexa que requer diagnóstico e tratamento imediatos. A detecção precoce é crucial devido à rápida evolução para necrose intestinal e sepse. A tomografia computadorizada é o método mais preciso, enquanto a angiografia mesentérica confirma o diagnóstico. O tratamento tem como objetivo restaurar o fluxo sanguíneo intestinal, através de angioplastia, stent ou cirurgia, e oferecer suporte intensivo para corrigir distúrbios e prevenir complicações.
The First (and Second) Known Occurrences of Bazzite in Canada – The Quadeville Rose Quartz Quarry, Ontario, and the Bugaboo Castles Aquamarine Deposit, British Columbia – Description and Crystal Structure
Authors: Piilonen Paula C. , Rowe Ralph , Poirier Glenn , Friis Henrik , Robak Chris , Bainbridge Michael 
Published: May 2024

Abstract
Bazzite, ideally Be3Sc2Si6O18, has been discovered for the first time at two granitic pegmatite localities in Canada: the Quadeville Rose Quartz quarry, Ontario (Bz-ON/CMNMC 90604), and the Bugaboo Castles aquamarine deposit, Purcell mountains, British Columbia (Bz-BC/CMNMC 90725). Bazzite from both Canadian localities occurs as colorless, hexagonal prismatic to acicular crystals up to 0.6 mm in length. The crystal chemistry and structure of the two samples, Bz-ON and Bz-BC, was determined and compared with bazzite from other known occurrences. The average composition of Bz-ON is Be2.99(Sc1.39Mg0.37Fe3+0.10Fe2+0.09Al0.06Mn0.01)Σ2.02Si5.99O18·[Na0.47(H2O)], and that of Bz-BC is Be3.00(Sc1.43Fe2+0.28Mg0.20Al0.05Fe3+0.03Mn0.01)Σ2.01Si6.00O18[(Na0.46Cs0.01)Σ0.47(H2O)]. Bazzite from the Quadeville Rose Quartz pegmatite contains Mg = 0.33–0.41 (avg. 0.37) apfu, Fe3+ = 0.00–0.18 (avg. 0.10) apfu, and Fe2+ = 0.05–0.13 (avg. 0.09) apfu, whereas bazzite from Bugaboo Castles is more Fe2+-rich, with Fe2+ = 0.19–0.38 (avg. 0.28) apfu, Mg = 0.16–0.22 (avg. 0.20) apfu, and Fe3+ = 0.00–0.08 (avg. 0.03) apfu. Both samples have low Al, Mn, Ca, and Cs contents and, compositionally, are more similar to bazzite from alpine fissures and orogenic pegmatites than that from more common anorogenic NYF pegmatites. Bazzite from Canada is hexagonal, P6/mcc, with unit cell parameters a = 9.52741(14), c = 9.19326(15) Å for Bz-ON and a = 9.54396, c = 9.16495(20) Å for Bz-BC, respectively. The structure is composed of SiO4 tetrahedra that share corners to form Si6O18 rings perpendicular to the c axis. Each Si6O18 ring is linked via corners to a 12-membered ring of edge-sharing BeO4 tetrahedra and AO6 octahedra (A), resulting in channels parallel to the c axis (2a and 2b sites). Voids in the channels contain H2O (2a) and large alkali cations (Na, 2b). Both Bz-ON and Bz-BC have fully occupied 2a sites and 2b sites which are 50% occupied by Na. Increased substitution of the smaller cations Mg ([6]r = 0.72 Å) and Fe3+ ([6]r = 0.65 Å) for Sc ([6]r = 0.75 Å) results in significant changes in the bazzite structure, including a decrease in the &lt;A–O&gt; distance and decreased distortions (compression) in the AO6 and SiO4 tetrahedra. Bazzite from Quadeville and Bugaboo Castles are late-stage minerals, the product of breakdown of beryl and/or bertrandite and a Sc-bearing mineral. At Bugaboo Castles, bazzite is the result of alteration of Sc-rich spessartine (up to 3000 ppm) and primary beryl by late-stage OH-bearing fluids. At Quadeville, the source of Sc for bazzite is less evident and suggested to be Sc-bearing columbite-group minerals (up to 0.23 apfu Sc), or primary ferromagnesian minerals.
Experience of stereotactic radiation therapy and radiosurgical treatment of metastatic vertebral tumors
Authors: Kit O. I. , Zakondyrin D. E. , Rostorguev E. E. , Sakun P. G. , Voshedskii V. I. , Komandirov M. A. 
Published: May 2024

Purpose of the study. Evaluation of the effectiveness of extracranial stereotactic radiation therapy in various fractionation regimens in the treatment of patients with metastatic vertebral lesions.Patients and methods. The study included 12 patients with metastatic spinal lesions who underwent extracranial stereotactic radiation therapy (SBRT) on a Novalis Tx linear accelerator, Varian, in radiosurgery mode (SRS; in 1 fraction) and hypofractionation mode (SFD 5Gy, TFD 25Gy, 5 fractions) in the period from 01/01/2020 to 03/31/2022. The assessment of local control was carried out using positron emission tomography – computed tomography (PET-CT) from 18FDG. The intensity of the pain syndrome before and after radiation was assessed using a visual analog pain scale (VAS).Results. 19 vertebrae with metastatic lesions were irradiated in 12 patients. The SBRT technique in hypofractionation mode was used in 6 (50 %) patients, in radiosurgery (SRS) mode was used in 4 (34 %) patients, in 2 (17 %) patients a combination of irradiation techniques was used on various affected segments of the spinal column. The general tumor volume (GTV) averaged 30.56 = 7.8 km2. When using the radiosurgical irradiation regimen, SFD ranged from 16 to 18 Gy. When using the hypofractionation technique, the total focal dose (TFD) was 25 Gy, a single focal dose (SFD) was 5 Gy.Conclusion. Stereotactic radiation therapy and radiosurgery of metastatic vertebral tumors without compression of neural structures provides local tumor control in 92 % of patients within 6 months and in 83 % of patients within 1 year, regression of pain after irradiation – in 67 % of patients.
Features of anorectal function after radiation therapy in patients with rectal cancer
Authors: Kit O. I. , Bondarenko O. G. , Gevorkyan Yu. A. , Soldatkina N. V. , Gusareva M. A. , Kosheleva N. G. , Solntseva A. A. , Petrov D. S. , Savchenko D. A. 
Published: May 2024

Purpose of the study. To study the function of the sphincter in patients with rectal cancer after chemoradiotherapy using the method of high-resolution anorectal manometry.Materials and methods. The study included 30 patients with cancer of the middle and lower ampullary rectum, who underwent combined treatment at the National Medical Research Center of Oncology. The patients underwent a course of neoadjuvant gamma radiation therapy using capecitabine. High-resolution anorectal manometry was performed before the start of treatment and 2 months after completion of chemoradiotherapy to study the functional parameters of the sphincter apparatus. The severity of anorectal dysfunction was assessed using the Wexner anal incontinence scale.Results. According to high-resolution anorectal manometry, the average pressure of the anal canal at rest decreased by 1.4 times (p < 0.05), and the average absolute compression pressure with voluntary contraction decreased by 1.2 times (p = 0.0012) after neoadjuvant chemoradiotherapy. A comparative assessment of the maximum absolute compression pressure at this stage of treatment did not allow us to trace a significant difference between its value before the start of radiation therapy and 2 months after its completion (p > 0.05). An increase in threshold sensitivity volumes was noted in 23 patients (p = 0.16). The use of the Wexner scale didn’t show a statistically significant change in the median scores according to the results of patient surveys following the completion of treatment (5.2 vs. 5.5 points, p > 0.05).Conclusions. Radiation therapy has an effect on anorectal function, which may contribute to the occurrence of low anterior resection syndrome after surgical treatment. For this reason, it is now necessary to carefully consider the risks of developing anorectal dysfunction. Equally important is the use of methods for the prevention of low anterior resection syndrome for patients who have received combined treatment for rectal cancer.
A Unified Treatment of Kepler Occurrence to Trace Planet Evolution. II. The Radius Cliff Formed by Atmospheric Escape
Authors: Dattilo Anne , Batalha Natalie M. 
Published: May 2024

Abstract
The Kepler mission enabled us to look at the intrinsic population of exoplanets within our galaxy. In period-radius space, the distribution of the intrinsic population of planets contains structure that can trace planet formation and evolution history. The most distinctive feature in period-radius space is the radius cliff, a steep drop-off in occurrence between 2.5 and 4R
⊕ across all period ranges, separating the sub-Neptune population from the rarer Neptunes orbiting within 1 au. Following our earlier work to measure the occurrence rate of the Kepler population, we characterize the shape of the radius cliff as a function of orbital period (10–300 days) as well as insolation flux (9500S
⊕–10S
⊕). The shape of the cliff flattens at longer orbital periods, tracking the rising population of Neptune-sized planets. In insolation, however, the radius cliff is both less dramatic and the slope is more uniform. The difference in this feature between period space and insolation space can be linked to the effect of EUV/X-ray versus bolometric flux in the planet’s evolution. Models of atmospheric mass loss processes that predict the location and shape of the radius valley also predict the radius cliff. We compare our measured occurrence rate distribution to population synthesis models of photoevaporation and core-powered mass loss in order to constrain formation and evolution pathways. We find that the models do not statistically agree with our occurrence distributions of the radius cliff in period space or insolation space. Atmospheric mass loss that shapes the radius valley cannot fully explain the shape of the radius cliff.
La situation en psychanalyse
Authors: Rousseaux Mosettig Christiane 
Published: May 2024

Freud a construit une nouvelle façon de décrire et de concevoir les phénomènes psychiques que l’invention de la règle fondamentale a rendu accessibles. Il propose en guise d’introduction à sa science l’étude des actes manqués, il en construit un modèle de recherche qui rend observable pour chacun ce qui ne l’était pas auparavant, et permet de se faire une idée de la manière dont travaille la psychanalyse. Il donne à son étude une « force démonstrative » mais chaque cas d’analyse peut aussi devenir démonstratif. Ce savoir ne se confond pas avec celui du désir inconscient se manifestant dans la cure, mais il y prend sa source et propose après coup un discours partageable, toujours en développement et jamais achevé.
La situation en psychanalyse
Authors: de M’Uzan Michel 
Published: May 2024

Au fil des années, des remaniements importants de l’édifice métapsychologique se sont imposés. Ils concernent essentiellement cinq sujets : Le rééquilibrage des rapports entre les topiques, à savoir la prévalence de la première topique et les conditions auxquelles la deuxième topique doit répondre pour pouvoir y être intégrée. L’abandon de la notion de pulsion de mort. Le rejet du qualificatif de pulsion pour l’autoconservation. L’adoption d’un nouveau vocabulaire en conformité avec les développements théoriques : le vital-identital. L’adoption de la théorie de la séduction, telle qu’étayée par des références cliniques.
Quality, Reliability, Readability, and Accountability of Online Information on Leukocoria
Authors: Eleiwa Taher K. , Dihan Qais A. , Brown Andrew D. , Zaldivar Ana T. , Abdelnaem Seif E. , Sallam Ahmed B. , Phillips Paul H. , Elnahry Ayman G. , Elhusseiny Abdelrahman M. 
Published: May 2024

Purpose:
To evaluate the quality, reliability, and readability of online patient educational materials on leukocoria.

Methods:
In this cross-sectional study, the Google search engine was searched for the terms “leukocoria” and “white pupil.” The first 50 search outcomes were evaluated for each search term based on predefined inclusion criteria, excluding duplicates, peer-reviewed papers, forum posts, paywalled content, and multimedia links. Sources were categorized as “institutional” or “private.” Three independent raters assessed each web-site for quality and reliability using DISCERN, Health on the Net Code of Conduct (HONcode), and JAMA criteria. Readability was evaluated using seven formulas: Flesch Reading Ease (FRE), Flesch-Kincaid Grade Level (FKGL), Simple Measure of Gobbledygook (SMOG) Index, Automated Readability Index (ARI), Linsear Write (LW), Gunning Fog Index (GFI), and Coleman-Liau Index (CLI).

Results:
A total of 51 websites were included. Quality, assessed by the DISCERN tool, showed a median score of 4, denoting moderate to high quality, with no significant differences between institutional and private sites or search terms. HONcode scores indicated variable reliability and trustworthiness (median: 10, range: 3 to 16), with institutional sites excelling in financial disclosure and ad differentiation. Additionally, institutional and private sites performed well in reliability and accountability, as measured by the JAMA Benchmark criteria (median: 3; range: 1 to 4). Readability, averaging an 11.3 ± 3.7 grade level, did not differ significantly between site types or search terms, consistently falling short of the recommended sixth-grade level for patient educational materials.

Conclusions:
The patient educational materials on leukocoria demonstrated moderate to high quality, commendable reliability, and accountability. However, the readability scores were above the recommended level for the layperson.

[
J Pediatr Ophthalmol Strabismus
. 2024;61(5):332–338.]
Long-term Ocular Alignment and Sensory Outcomes After Medial Rectus Recession for High AC/A Ratio Esotropia
Authors: Mohan Kanwar , Sharma Suresh Kumar 
Published: May 2024

Purpose:
To report long-term ocular alignment and sensory outcomes after medial rectus recession for high accommodative convergence/accommodation (AC/A) ratio esotropia.

Methods:
The medical records of consecutive patients who had undergone unilateral or bilateral medial rectus recession for high AC/A ratio esotropia and were observed postoperatively for a minimum of 5 years were reviewed retrospectively.

Results:
A total of 34 patients were included. Twenty-three patients (68%) used bifocals preoperatively. The mean age at surgery was 11.5 ± 4.4 years (range: 2.5 to 19.0 years). The mean postoperative follow-up was 7.5 ± 2.3 years (range: 5.0 to 15.25 years). Overall, 21 patients (62%) had surgical success at their last follow-up visit. Age at surgery, preoperative angle of distance and near deviation, distance-near disparity, and preoperative bifocal wear did not predict motor outcome after surgery. Preoperative presence of peripheral binocular single vision was a significant favorable factor for surgical success. At the last follow-up visit, 21% of patients had a recurrence of high AC/A ratio esotropia and 9% each had consecutive exotropia (intermittent [3%] and constant [6%]) and basic esotropia. Peripheral binocular single vision was achieved in 64% of patients and stereopsis in 28%. Bifocal segment was eliminated postoperatively in 70% of patients.

Conclusions:
Nearly two-thirds of patients with high AC/A ratio esotropia achieved a successful long-term motor outcome and peripheral binocular single vision, and nearly one-fourth achieved stereopsis. Recurrence of high AC/A ratio esotropia occurred in some patients, and consecutive exotropia and basic esotropia in a few. Bifocal segment was eliminated postoperatively in 70% of patients.

[
J Pediatr Ophthalmol Strabismus
. 2024;61(5):344–350.]
Long-term, Low-Dose Oral Azithromycin Treatment for Chronic Severe Bilateral Blepharokeratoconjunctivitis in Pediatric Patients
Authors: Sari Esin Sogutlu , Ozmen Ahmet Tuncer , Yildiz Meral , Akova Berna , Baykara Mehmet , Hasanova Shole 
Published: May 2024

Purpose:
To evaluate the efficacy and safety of oral azithromycin treatment combined with topical antibiotic and anti-inflammatory agents in pediatric patients with chronic severe bilateral blepharokeratoconjunctivitis.

Methods:
Patients younger than 14 years with chronic and severe bilateral blepharokeratoconjunctivitis were reviewed retrospectively. Consecutive patients receiving oral azithromycin treatment were included. All patients received oral azithromycin (5 mg/kg/single dose daily) for at least 4 weeks combined with topical antibiotic and anti-inflammatory agents. Before and after the treatment, clinical symptoms were noted, and corneal and conjunctival fluorescein staining and corneal neovascularization were graded. Meibomian gland secretion and meibomian gland plugging were also assessed. All patients completed at least 3 months of follow-up after completion of the oral azithromycin treatment. Patients' clinical data at the time of diagnosis and last follow-up visit were statistically compared.

Results:

Twenty-nine children (58 eyes, mean age of 6.51 years) were included. The mean time of oral azithromycin use was 5.87 weeks (range: 4 to 10 weeks). Clinical symptoms and signs and visual acuity were significantly improved after treatment. The mean fluorescein staining and corneal neovascularization grades and meibomian gland secretion and meibomian gland plugging scores also improved after treatment (
P
< .001). Eyelid distortion or fornix shortening was not observed. At the last follow-up visit, all patients were stable with treatment only with daily eyelid hygiene, topical cyclosporine, and artificial tears.

Conclusions:
Long-term, low-dose oral azithromycin combined with topical antibiotic and anti-inflammatory agents is an effective treatment option for pediatric patients with chronic severe bilateral blepharokeratoconjunctivitis.

[
J Pediatr Ophthalmol Strabismus
. 2024;61(5):358–364.]
Des entrepreneurs qui ont « le cœur à la bonne place » : enquête sociologique sur les pratiques d’intérêt général parmi les entrepreneurs en coopératives de travail au Québec
Authors: Rivet-Préfontaine Louis 
Published: May 2024

À partir de cas québécois, l’article illustre les apports analytiques d’une approche qualitative de sociologie de la connaissance pour l’étude des pratiques d’« intérêt général » chez des entrepreneurs en coopératives de travail. Celles-ci sont interprétées comme des réactualisations contemporaines de la logique de l’économie du don canadienne-française, et dont il s’agit d’exposer les conditions socioéconomiques d’expression et d’absence. Il est révélé que, chez les personnes en ayant fait l’apprentissage, la logique du don ne disparaît pas. Plutôt, elle se transfère ou prend de l’expansion à la mesure de l’intégration dans des réseaux de collaboration propres à ces secteurs.