bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leveraging Radiotherapy Data for Precision Oncology: Veterans Affairs Granular Radiotherapy Information Database
Authors: Katsoulakis Evangelia , Madison Cecelia J. , Kapoor Rishabh , Melson Ryan A. , Gao Anthony , Bian Jiantao , Hausler Ryan M. , Danilov Peter N. , Nickols Nicholas G. , Solanki Abhishek A. , Sleeman William C. , Palta Jatinder R. , DuVall Scott L. , Lynch Julie A. , Thompson Reid F. , Kelly Maria 
Published: February 2025

PURPOSE
Despite the frequency with which patients with cancer receive radiotherapy, integrating radiation oncology data with other aspects of the clinical record remains challenging because of siloed and variable software systems, high data complexity, and inconsistent data encoding. Recognizing these challenges, the Veterans Affairs (VA) National Radiation Oncology Program (NROP) is developing Granular Radiotherapy Information Database (GRID), a platform and pipeline to combine radiotherapy data across the VA with the goal of both better understanding treatment patterns and outcomes and enhancing research and data analysis capabilities.

METHODS
This study represents a proof-of-principle retrospective cohort analysis and review of select radiation treatment data from the VA Radiation Oncology Quality Surveillance Program (VAROQS) initiative. Key radiation oncology data elements were extracted from Digital Imaging and Communications in Medicine Radiotherapy extension (DICOM-RT) files and combined into a single database using custom scripts. These data were transferred to the VA's Corporate Data Warehouse (CDW) for integration and comparison with the VA Cancer Registry System and tumor sequencing data.

RESULTS
The final cohort includes 1,568 patients, 766 of whom have corresponding DICOM-RT data. All cases were successfully linked to the CDW; 18.8% of VAROQS cases were not reported in the existing VA cancer registry. The VAROQS data contributed accurate radiation treatment details that were often erroneous or missing from the cancer registry record. Tumor sequencing data were available for approximately 5% of VAROQS cases. Finally, we describe a clinical dosimetric analysis leveraging GRID.

CONCLUSION
NROP's GRID initiative aims to integrate VA radiotherapy data with other clinical data sets. It is anticipated to generate the single largest collection of radiation oncology–centric data merged with detailed clinical and genomic data, primed for large-scale quality assurance, research reuse, and discovery science.
Minimal Residual Disease–Based End Point for Accelerated Assessment of Clinical Trials in Multiple Myeloma: A Pooled Analysis of Individual Patient Data From Multiple Randomized Trials
Authors: Shi Qian , Paiva Bruno , Pederson Levi D. , Dimier Natalie , Talpes Ela , Prior Thomas J. , Orfao Alberto , Moreau Philippe , Sonneveld Pieter , Kumar Shaji K. , Dixon Jesse G. , Patel Reshma , Bartlett Blake J. , Schecter Jordan , McCarthy Phillip , Hose Dirk , Seckinger Anja , Mattia D'Agostino , Goldschmidt Hartmut , Oliva Stefania , Owen Roger G. , Anderson Kenneth C. , San-Miguel Jesús , Durie Brian G.M. , Munshi Nikhil ,   on behalf of the International Independent Team for Endpoint Approval of Myeloma Minimal Residual Disease (i2TEAMM) Group
Published: February 2025

PURPOSE
Newly approved drugs and combinations treating multiple myeloma (MM) have resulted in substantial improvements in patients' survival. To deliver rapid access to newer therapies, an earlier end point to expedite clinical trials is needed. Our objective was to evaluate the minimal residual disease–negative complete response (MRD-CR) as an intermediate end point for progression-free survival (PFS) and overall survival (OS) in newly diagnosed (ND) transplant-eligible (NDTE) patients, ND transplant-ineligible (NDTinE) patients, and patients with relapsed/refractory (RR) MM.

PATIENTS AND METHODS

Individual patient data from 20 randomized multicenter trials were collected. Eleven studies (4,773 patients) with sufficient data were analyzed to evaluate whether 9- or 12-month MRD-CR classified at a 10
–5
threshold could be reasonably likely to predict the clinical benefit of new agents regarding PFS and OS. Global odds ratio (OR) was estimated using the bivariate Plackett Copula model. Supportive evaluation included correlations of the treatment effects on MRD-CR end points and PFS/OS, evaluated by both linear regression (
R
2
weighted least squared
) and Copula (
R
2
Copula
) models.

RESULTS

The analysis demonstrated that both 9- and 12-month MRD-CR strongly correlated with PFS at patient level in NDTE patients, NDTinE patients, and patients with RRMM. Global ORs ranged from 3.06 to 16.24, all with 95% CIs excluding 1.0. Encouraging trial-level correlations (
R
2
, 0.61-0.70) were observed by pooling three populations and were stronger (
R
2
, 0.67-0.78) in the ND population. Similar results were observed for OS.

CONCLUSION

Our findings provided the support for use of MRD-CR classified at a 10
–5
threshold at either 9 or 12 months after starting of the treatment, as an intermediate end point to support accelerated approvals, in future trials in NDTE patients, NDTinE patients, and patients with RRMM.
Cancer Susceptibility Gene Testing in Patients With Pancreatic Ductal Adenocarcinoma: Implementation in a Cancer Center Oncology Clinic
Authors: Sinan Hassan , Cunningham Dea , Sleiman Emy Abou , Petry Dana , McPhaul Thomas , Visvanathan Kala , Armstrong Deborah K. , He Jin , Burkhart Richard , Pishvaian Michael J. , Zheng Lei , Zaidi Neeha , Azad Nilofer S. , Laheru Daniel , Goggins Michael 
Published: February 2025

PURPOSE
Current guidelines recommend offering genetic susceptibility testing to individuals with pancreatic cancer regardless of family history, but previous studies have reported only moderate test uptake, highlighting the need for efficient and accessible clinical pathways for delivering pretest genetic education and testing. We evaluated gene testing uptake offered at the point-of-oncology care by a nongenetics provider in an outpatient setting.

METHODS
A retrospective chart review was performed of patients with pancreatic cancer treated at the Johns Hopkins Hospital between January 2021 and December 2023. During their initial clinic visit, patients were educated about germline testing by an oncology nurse and provided with educational and instructional handouts and video links, including how to arrange testing (with saliva) with a commercial testing provider. Patients with pathogenic variants and variants of uncertain significance were referred for genetic counseling.

RESULTS
Of the 992 patients seen in the oncology clinic (52.1% male, 75.4% White, 15.4% African American, 6% Asian; median age at diagnosis, 66.9 ± 10.6 years), 90% were offered testing, 77.6% of whom completed it. Factors significantly associated with not going forward with testing included being single, older age, African American, and having advanced-stage disease. Among the tested individuals, 78 (11.3%) had a pathogenic variant identified, including 55 (7.9%) with a pancreatic cancer susceptibility gene variant; of these, 72 (92.3%) were referred for genetic counseling and 50 (69.4%) completed their counseling visit. Testing led to a change in chemotherapy regimen in 28 patients.

CONCLUSION
The implementation of point-of-care encounters for cancer susceptibility gene testing by an oncology nurse in the outpatient setting yielded a high uptake of testing. Additional approaches are needed to increase testing rates and cancer genetics visits.
Early universe inverted harmonic oscillator model over ultrametric space
Authors: Radovancevic Darko , Nesic Ljubisa , Radenkovic Lazar 
Published: February 2025

Abstract
One of the interesting models we occasionally come across in physics is the inverted harmonic oscillator. This paper demonstrates that the dynamics of the flat Friedmann minisuperspace cosmological model, in both classical and quantum scenarios, can be reduced to analyzing the dynamics of the one-dimensional inverted harmonic oscillator with a time-dependent frequency. Early in the paper, following the standard approach, the Lagrangian for the flat Friedmann model is constructed, which takes the form of the Lagrangian for the inverted harmonic oscillator with a time-dependent frequency. The classical action and the Feynman propagator are determined in spaces with both non-ultrametric and ultrametric geometries. For the quantum mechanical form of the model over ultrametric space, vacuum p-adic states and the conditions of their existence have been determined. At the end of the paper, the adelization of the model pointed to the necessity of discretization of the minisuperspace in the early stages of dynamic evolution.
Stress-Free Voluntary Exercise Promotes Prophylactic Enhancement of Stress Resilience via the Nucleus Reuniens Affecting the Medial Prefrontal Cortex–Hippocampal Pathway
Authors: Hwang Dong-Joo , Cho Joon-Yong 
Published: February 2025

ABSTRACT

Purpose
Stress is a risk factor for psychiatric illnesses. However, not all individuals exposed to stress will develop affective disorders. We examined whether pretreatment with stress-free voluntary wheel running (VWR) exercise prophylactically enhances stress resilience in rodents and how it can effectively prevent the development of depressive- and anxiety-like behaviors.

Methods
Eight-week-old C57BL6/J mice were housed in cages with VWR and subjected to chronic restraint stress (CRST) for 2 h daily for 14 days. The mice were assessed for depressive- and anxiety-like behaviors, and a behavioral matrix (k-means clustering) was introduced to segregate the mice into susceptible and resilient subpopulations. Chemogenetic inhibition and retrograde tracing were used to map the neural circuits involved in VWR’s resilience-enhancing properties.

Results
After CRST exposure, 71.50% of CRST mice with VWR were stress resilient, with less stress-induced prolonged activation of the hypothalamic–pituitary–adrenal (HPA) axis and corticosterone (CORT) response, representing a 57.20% increase compared with CRST-only mice. Staining for c-Fos showed that VWR activated predominantly hippocampal GABAergic neurons and suppressed the activity in the medial prefrontal cortex (mPFC). Chemogenetic inhibition of the ventral hippocampus (vHPC) dissipated the antidepressant and anxiolytic effects of VWR pretreatment. In addition, the nucleus reuniens (NR) was implicated in VWR’s resilience-enhancing properties, relaying reciprocal interactions of the mPFC–vHPC pathway.

Conclusions
These findings suggest that stress-free voluntary exercise may be an effective modality for stress management and warrant further investigation into its resilience-enhancing mechanisms.
Comparison of dietary and supplemental calcium - a systematic review
Authors: Siembab Karolina , Garbarczyk Wiktor , Napieralska Agnieszka , Kapla Albert , Černohorská Alicja , Bednarczyk Daria , Białeta Julia , Rowińska Katarzyna , Jurkiewicz Michalina , Pysiewicz Wiktoria 
Published: February 2025

Calcium is an essential mineral crucial for several physiological processes. The public has generally perceived its supplementation as beneficial or, at the least, neutral. Additional supplementation has been gaining popularity in recent years, often without professional consultation. This is despite the fact that dietary calcium is mostly sufficient in healthy individuals to meet daily requirements. This review examines studies found on PubMed to contrast dietary calcium intake with supplemental calcium with regard to two specific issues – cardiovascular risk and kidney stone risk.
Research suggests that while dietary calcium protects against cardiovascular disease and nephrolithiasis, supplemental calcium may increase the risk of myocardial infarction and arterial calcification in specific populations.
Therefore, healthcare providers ought to prioritize dietary calcium sources and implement an individualized approach for patients who require such supplementation, such as those at risk of osteoporosis or CVD. The timing and dosage of calcium supplements also require careful consideration. Further research is needed to examine the mechanisms behind these risks and specify clinical guidelines for safe and effective calcium intake.
GLP-1 Receptor Agonists’ Impact on Fertility - A Review
Authors: Wojda Joanna , Lesiczka-Fedoryj Katarzyna , Walczak Anna , Kościuszko Zuzanna , Sobiński Adam , Czerwonka Matylda , Kurza Katarzyna , Podolec Julianna , Ciraolo Silvia , Agnieszka Kulczycka-Rowicka  
Published: February 2025

Purpose of Research: The aim of the research is to summarize the impact of GLP-1 analogs on fertility according to clinical studies, particularly in obese or overweight women with PCOS.
Research Materials and Methods: The study is built upon an analysis of current literature, clinical trials, meta-analyses, and systematic reviews as well as press reports from various sources. Data were collected from studies examining the effects of obesity on fertility, as well as the impact of GLP-1 analogs on both fertility and obesity.
Basic Results: GLP-1 analogs promote weight management among obese and overweight patients leading to improvement in their fertility. Furthermore, they improve pregnancy rates in women with PCOS, although further examination is needed.
Conclusions: We observe, GLP-1 analogs are often used in regulation of type 2 diabetes. They have proven their ability to impact a variety of hormonal as well as metabolic pathways. They manage glucose metabolism, appetite, as well as insulin secretion. Alongside their metabolic influence, research demonstrates that GLP-1 analogs may have an effect on the reproductive system, involving fertility via metabolic and hormonal pathways.
Long Lags and Large Returns: Experimental Evidence from Advertising to Businesses
Authors: Thomas Michael , Goic Marcel , Kalyanam Kirthi 
Published: February 2025

Using a multiyear experiment, we show that advertising to businesses can generate very different responses than has been observed for consumers. First, we estimate larger advertising returns than typically found for consumers: a return on ad spend of 12.0 (95% CI: 4.8–24.5). Second, we estimate longer lags between ad delivery and purchase: 1–5 months for first-time purchases and 5–12 months or longer for repeat purchases. Third, we find that existing business customers are responsible for most of the revenue lift from advertising, though this appears to be driven by existing business customers purchasing new parts. Additionally, our results demonstrate that geography-based switchback experiments that randomize the time between treatments can provide an effective means of estimating lagged effects. For this study we randomized the delivery of digital display ads for electronic components offered by a semiconductor manufacturer; nearly all electronic products require such components. This paper was accepted by Duncan Simester, marketing. Funding: M. Goic acknowledges partial funding by ANID Chile [Grants PIA AFB230002 and Fondecyt No. 1221711] and the Institute for Research in Market Imperfections and Public Policy (IS130002 ANID); K. Kalyanam acknowledges financial support from the co-operating company; and M. Thomas acknowledges financial support from National University of Singapore [Startup Grant A-0003320-01-00]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.02661 .
Understanding Emotional State on Female Correctional Officers in Java, Indonesia
Authors: Prasetyo Anggun Resdasari , Ratnaningsih Ika Zenita , Prihatsanti Unika 
Published: February 2025

AbstractÂ Â Correctional institution has employees who are tasked with guarding inmates. High-risk job tasks that have to be faced by correctional officer can potentially affect the emotional state, moreover, if the officer is female gender. Based on the background, the study was aimed to know about the emotional state on female correctional officers. The research method used was clinical exploration by conducting in-depth interviews on 30 female correctional officers in Bandung and Semarang. The results can be concluded that the emotions experienced by the subjects in the study are mostly negative emotions. Negative emotions of anger, sadness, guilty, and anxiety is felt almost entirely by the 26 subject and only 4 subjects have positive emotional state, namely happiness and pride. From the data, there were 23 subjects who did positive emotion regulation, consist of 4 subjects who indeed were subjects who had positive emotional state and 19 subjects who initially had negative emotional state but were able to regulate emotions well. 19 of the 26 subjects who experienced negative emotional conditions tried to regulate positive emotions so that they could do a good job. Positive emotional regulations have been done by 23 subjects are positive reappraisal, refocus on planning, positive refocusing, and acceptance. The emotional regulation strategy used by 7 subjects was negative strategies, such as blaming other, self-blaming, and rumination or focus on thought.Â Keywords: Emotions at work, Correctional officer, Female.
Systematic Review : Violation of Integrity from the Perspective of Psychology, Organizational Context and Community Culture
Authors: Rahayuningsih Idha , Suhariadi Fendy , Suhariadi Fendy , Hadi Cholichul , Hadi Cholichul 
Published: February 2025

AbstractThe report on the crackdown on ICW corruption cases in 2019 explained that during 2019 there were 271 cases in Indonesia, as many as 29 (10.7%) cases occurred at the national level and 242 (89.3%) occurred in various regions in Indonesia. These data indicate the existence of integrity violations committed by public officials. The purpose of the literature review is to explore the psychological, organizational, and cultural factors of society that affect integrity violations. Research methods are systematic reviews. The results of the literature review: 1) psychological factors include low universal basic values and virtues, low moral judgment, low risk perception, low shame and guilt, high love of money, high machiavellianism, external motivation, authority, wealth, status and affiliation motivation, luxurious and hedonistic lifestyle and low happiness;Â Â Â Â 2) organizational factors are quite varied, including an ethical climate that is perceived negatively and self-oriented, less transparent organization, Human Resources and performance systems, politicization of the bureaucracy, the role model of the leader / superior is not good, several other factors; 3) Community cultural factors include high power distance, high masculinity, high collectivism and avoiding low uncertainty.Key Word : Violation of Integrity, Psyhology, Organizational Context,Â Community Culture
Physical Activity Frequency and Mental Health in Old Age: A Bidirectional Association
Authors: Juhendra Juhendra , EkaIzzaty Rita , Wibowo Yoga Setyo 
Published: February 2025

The association between physical activity and mental health have been found bidirectional in the literature. However, evidence of this bidirectional association is lacking from developing countries. This study was aimed at investigating the bidirectional relationship between physical activity frequency and mental health in old age using data from the Indonesia Family Life Survey with a sample of 8,323 old individuals aged between 45 and 90 years.Â The results revealed that the bidirectional association holds true in old age. Specifically, an increase of one unit in frequency of physical activity is associated with a decrease of 14% in depression after controlling for a set of confounding variables. Similarly, an increase of one unit in depression is associated with a decrease of 3.4% in frequency of physical activity. The results of this study suggest that health policies should take into account the importance of the frequency of physical activity.Keywords: frequency of physical activity, mental health, depression, old age, Indonesia
A Comparative Floor Assembly Design and Life-Cycle Assessment Study of Steel–Timber and Steel–Concrete Composite Structural Systems
Authors: Rohde Ellrich Emma , Via Brian , Roueche David , Sener Kadir 
Published: February 2025

Abstract
Steel-timber composite (STC) structures, which utilize mass-timber cross-laminated-timber (CLT) floor panels compositely connected to steel framing, have emerged as a viable alternative structural system with a low carbon footprint along with potential improvements in the structural performance and constructability against traditional steel–concrete (SCC) systems. This paper focuses on the floor assembly design and sustainability aspect of STC systems relative to SCC systems with particular emphasis on results from a comparative whole-building life-cycle-assessment study conducted on functionally equivalent STC and SCC office buildings at 7 and 18 stories. Embodied carbon was lower in the STC systems since the total embodied carbon reduced by 50 and 42 percent in the 7- and 18-story structures, respectively. Embodied fossil energy was also lower in the STC systems since the total embodied fossil energy reduced by 32 and 21 percent in the 7- and 18-story structures, respectively. Sensitivity studies on biogenic carbon inclusion have shown substantial impact on the results.
Veränderungen der Organisationskultur und des Business-IT-Alignments während und nach der COVID-19-Pandemie am Beispiel einer Schweizer Hochschule
Authors: Russ Christian , Sieber Marcel R. , Weber Christian , Leikert-Böhm Ninja 
Published: February 2025

Zusammenfassung
In einer Fallstudie aus dem Jahr 2020 wurden auf Basis eines Business-IT-Alignment-Modellansatzes die Ausprägungen verschiedener Organisationskulturtypen im Hochschulkontext während der COVID-19-Pandemie analysiert. Hierbei wurden Mitarbeitende der Abteilung Informations- und Kommunikationstechnologie sowie betroffene Stakeholder interviewt. Die Studie zeigte unterschiedliche Abstimmungs- und Kulturformen auf verschiedenen Managementebenen auf, die halfen, den Hochschulbetrieb während der Pandemie aufrecht zu erhalten. Im Jahr 2022 wurde mit einem vergleichbaren Setup eine Folgestudie durchgeführt, um mögliche Veränderungen nach der COVID-19-Pandemie festzustellen. Es zeigten sich partielle Unterschiede in der Zusammenarbeit und der Führung. Der Fokus der Informations- und Kommunikationstechnologie hatte sich von strategischen Überlegungen hin zu operativen und kundenorientierten Dienstleistungen verschoben. Die Hochschulleitung wurde vorwiegend als Prioritätensetzerin wahrgenommen, während sich das Informations- und Kommunikationstechnologie-Management vermehrt auf die Umsetzung von Strategien konzentrierte. Zudem hatte das während des Beobachtungszeitraums eingeführte agile Framework SAFe® für Verschiebungen gesorgt. Die Organisationskultur wurde vorwiegend als eine Mischung aus Clan- und Hierarchiekultur beschrieben, wobei Innovation und Risikobereitschaft ein Stück weit verloren gingen. Die Rückkehr zur Normalität richtete das Augenmerk verstärkt auf strukturierte Abläufe; einige positive Aspekte der Pandemiezeit, wie Teamzusammenhalt und Innovationsgeist, hatten etwas nachgelassen. Die Studie lässt den Schluss zu, dass eine nachhaltige Kulturveränderung einen längeren Atem benötigt und die Einführung einer agilen Organisationsform noch weitere Reifegrade durchlaufen muss. Diese Ergebnisse können im Sinne einer IT-Business-Partnerschaft Anregungen geben, um in Zukunft besser auf radikale Veränderungen vorbereitet zu sein und den Wertbeitrag der IT als Ganzes zu steigern.