bluuebunny/crossref_metadata_2025_split huggingface dataset:
In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype
Authors: Cao Ye , Boss Anna L. , Bolam Scott M. , Munro Jacob T , Crawford Haemish , Dalbeth Nicola , Poulsen Raewyn C. , Matthews Brya G. 
Published: June 2024

AbstractCell surface marker expression is one of the criteria for defining human mesenchymal stem or stromal cells (MSC) in vitro. However, it is unclear if expression of markers including CD73 and CD90 reflects the in vivo origin of cultured cells. We evaluated expression of 15 putative MSC markers in primary cultured cells from periosteum and cartilage to determine whether expression of these markers reflects either the differentiation state of cultured cells or the self-renewal of in vivo populations. Cultured cells had universal and consistent expression of various putative stem cell markers including > 95% expression CD73, CD90 and PDPN in both periosteal and cartilage cultures. Altering the culture surface with extracellular matrix coatings had minimal effect on cell surface marker expression. Osteogenic differentiation led to loss of CD106 and CD146 expression, however CD73 and CD90 were retained in > 90% of cells. We sorted freshly isolated periosteal populations capable of CFU-F formation on the basis of CD90 expression in combination with CD34, CD73 and CD26. All primary cultures universally expressed CD73 and CD90 and lacked CD34, irrespective of the expression of these markers ex vivo indicating phenotypic convergence in vitro. We conclude that markers including CD73 and CD90 are acquired in vitro in most ‘mesenchymal’ cells capable of expansion. Overall, we demonstrate that in vitro expression of many cell surface markers in plastic-adherent cultures is unrelated to their expression prior to culture.
Graphical Abstract
Ambivalent Sexism Impacts Attitudes Toward Marital Surname Change Decisions
Authors: Palmwood Erin N. 
Published: June 2024

AbstractCouples are making increasingly varied surname change decisions following marriage. However, despite this increased variability, cultural attitudes toward nontraditional surname choices remain rooted in sexism, with women who retain their maiden names often being viewed negatively as individuals and as partners within their marriages. The present study aimed to examine ambivalent sexism as a potential moderator of the link between women’s and men’s nontraditional surname choices and negative perceptions of those individuals and their marriages. To this end, participants (n = 129) viewed a series of vignettes describing heterosexual couples who made traditional vs. nontraditional choices regarding whether to change or retain their surnames following marriage, and participants’ levels of ambivalent sexism were measured. Results indicated that participants with higher levels of sexism perceived nontraditional surname choices, and the individuals who make those choices, more negatively relative to those who make traditional choices. These findings underscore the persistent role of sexism in cultural attitudes toward marital surname choices in an emerging adult population.
Nomograms incorporating hsa_circ_0029325 highly expressed in exosomes of hepatocellular carcinoma predict the postoperative outcomes
Authors: Yin Kun-Li , Sun Taiwei , Duan Yu-Xin , Ye Wen-Tao , Ming Li  , Liao Rui 
Published: June 2024

Abstract
Background
Liquid biopsies, for example, exosomal circular RNA (circRNA) can be used to assess potential predictive markers for hepatocellular carcinoma (HCC) in patients after curative resection. This study aimed to search for effective prognostic biomarkers for HCC in patients after surgical resection based on exosomal circRNA expression profiles. We developed two nomograms incorporating circRNAs to predict the postoperative recurrence-free survival (RFS) and overall survival (OS) of HCC patients.

Method
Plasma exosomes isolated from HCC patients and healthy individuals were used for circRNA microarray analysis to explore differentially expressed circRNAs. Pearson correlation analysis was used to evaluate the correlation between circRNAs and clinicopathological features. Cox regression analysis was used to explore the correlation between circRNA and postoperative survival time as well as recurrence time. A nomogram based on circRNA and clinicopathological characteristics was established and further evaluated to predict prognosis and recurrence.

Result
Among 60 significantly upregulated circRNAs and 25 downregulated circRNAs, hsa_circ_0029325 was selected to verify its power for predicting HCC outcomes. The high expression level of exosomal hsa_circ_0029325 was significantly correlated with OS (P = 0.001, HR = 2.04, 95% CI 1.41–3.32) and RFS (P = 0.009, HR = 1.62, 95% CI 1.14–2.30). Among 273 HCC patients, multivariate regression analysis showed that hsa_circ_0029325 (HR = 1.96, 95% CI 1.21–3.18), tumor size (HR = 2.11, 95% CI 1.33–3.32), clinical staging (HR = 2.31, 95% CI 1.54–3.48), and tumor thrombus (HR = 1.74, 95% CI 1.12–2.7) were independent risk factors for poor prognosis in HCC patients after radical resection. These independent predictors of prognosis were incorporated into the two nomograms. The AUCs under the 1-year, 3-year, and 5-year survival and recurrence curves of the OS and RFS nomograms were 0.755, 0.749, and 0.742 and 0.702, 0.685, and 0.642, respectively. The C-index, calibration curves, and clinical decision curves showed that the two prediction models had good predictive performance. These results were verified in the validation cohort with 90 HCC patients.

Conclusion
Our study established two reliable nomograms for predicting recurrence and prognosis in HCC patients. We also show that it is feasible to screen potential predictive markers for HCC after curative resection through exosomal circRNA expression profile analysis.
Real-world experience with venetoclax-based therapy for patients with myeloid sarcoma
Authors: Jian Xinyi , Cha Jie , Lin Zhijuan , Xie Siting , Huang Yueting , Lin Yun , Zhao Haijun , Xu Bing , Luo Yiming 
Published: June 2024

Abstract
Background
The treatment of myeloid sarcoma (MS) is challenging and has not markedly improved patient prognosis. The introduction of venetoclax (VEN) has changed the treatment of MS, and venetoclax-based therapy has been described as very promising in several case reports.

Methods
In this retrospective study, we analyzed the treatment outcomes of 14 patients with MS treated with venetoclax-based therapy at The First Affiliated Hospital of Xiamen University from January 2020 to October 2023

Results
The cohort consisted of 7 (50%) women and 7 (50%) men with an average age of 37.5 years. Four patients (28.6%) had isolated MS de novo, 2 (14.2%) were diagnosed synchronously with AML, and 8 (57.2%) had isolated extramedullary relapse. The most common sites for MS in our cohort were the skin and lung, followed by the spinal canal, soft tissue, bone and kidney. Five patients were affected at more than three sites. Nine patients received VEN in combination with azacytidine, and 5 patients received VEN in combination with other agents. The median number of venetoclax therapies administered was 2 cycles (range: 1–10 cycles). A response was observed in all patients included in the study, with 8 patients (57.2%) achieving a CR and 3 patients (21.4%) achieving a PR, corresponding to an ORR (including CR and PR) of 78.6%. The median follow-up time for all patients was 13 months (range 1–44 months), and the 1 year OS for all patients was 67.7%.

Conclusions
Venetoclax-based therapy shows excellent efficacy and safety in MS patients in the “real world” at a single institution, and a corresponding prospective study is needed to verify this conclusion.
Flow and sound fields of scaled high-speed trains with different coach numbers running in long tunnel
Authors: Li Qiliang , Sun Yuqing , Ouyang Menghan , Yang Zhigang 
Published: June 2024

AbstractSegregated incompressible large eddy simulation and acoustic perturbation equations were used to obtain the flow field and sound field of 1:25 scale trains with three, six and eight coaches in a long tunnel, and the aerodynamic results were verified by wind tunnel test with the same scale two-coach train model. Time-averaged drag coefficients of the head coach of three trains are similar, but at the tail coach of the multi-group trains it is much larger than that of the three-coach train. The eight-coach train presents the largest increment from the head coach to the tail coach in the standard deviation (STD) of aerodynamic force coefficients: 0.0110 for drag coefficient (Cd), 0.0198 for lift coefficient (Cl) and 0.0371 for side coefficient (Cs). Total sound pressure level at the bottom of multi-group trains presents a significant streamwise increase, which is different from the three-coach train. Tunnel walls affect the acoustic distribution at the bottom, only after the coach number reaches a certain value, and the streamwise increase in the sound pressure fluctuation of multi-group trains is strengthened by coach number. Fourier transform of the turbulent and sound pressures presents that coach number has little influence on the peak frequencies, but increases the sound pressure level values at the tail bogie cavities. Furthermore, different from the turbulent pressure, the first two sound pressure proper orthogonal decomposition (POD) modes in the bogie cavities contain 90% of the total energy, and the spatial distributions indicate that the acoustic distributions in the head and tail bogies are not related to coach number.
Easily porting material point methods codes to GPU
Authors: Buckland Edward , Nguyen Vinh Phu , de Vaucorbeil Alban 
Published: June 2024

AbstractThe material point method (MPM) is computationally costly and highly parallelisable. With the plateauing of Moore’s law and recent advances in parallel computing, scientists without formal programming training might face challenges in developing fast scientific codes for their research. Parallel programming is intrinsically different to serial programming and may seem daunting to certain scientists, in particular for GPUs. However, recent developments in GPU application programming interfaces (APIs) have made it easier than ever to port codes to GPU. This paper explains how we ported our modular C++ MPM code to GPU without using low-level hardware APIs like CUDA or OpenCL. We aimed to develop a code that has abstracted parallelism and is therefore hardware agnostic. We first present an investigation of a variety of GPU APIs, comparing ease of use, hardware support and performance in an MPM context. Then, the porting process of to the Kokkos ecosystem is detailed, discussing key design patterns and challenges. Finally, our parallel C++ code running on GPU is shown to be up to 85 times faster than on CPU. Since Kokkos also supports Python and Fortran, the principles presented therein can also be applied to codes written in these languages.
Core Dimensions of Social Inclusion for Residents with Mental Health and/or Substance Use Challenges: A Qualitative Meta-synthesis
Authors: Ogundipe Esther , Sælør Knut Tore , Biong Stian , Gonzalez Marianne Thorsen 
Published: June 2024

AbstractPromoting social inclusion of persons with mental health and/or substance use challenges is a political priority. Despite this, this group continues to face multiple obstacles to feeling socially included. Considering the importance of experiencing social inclusion for a person’s recovery process and quality of life, an in-depth understanding of what characterizes social inclusion for this group is warranted. This meta-synthesis aimed to synthesize the qualitative findings from original research papers addressing social inclusion in a supported housing context from the perspectives of residents with mental health and/or substance use challenges.. This meta-synthesis was designed according to the recommendations of Sandelowski and Barroso (2007). Systematic searches in databases were conducted in Ovid Medline, Embase, CINAHL Complete, PsycINFO, Web of Science, and Scopus. Fourteen papers met the inclusion criteria and were included. The extracted data were analyzed in line with Graneheim and Lundman’s (2004) descriptions of qualitative content analysis. The analysis resulted in three overarching categories describing core dimensions of residents’ experiences with social inclusion: having access to core resources, participating actively oneself, and being existentially anchored. All categories contained sub-categories. Based on the findings, a new multidimensional conceptualization of social inclusion in a supported housing context was developed.
Characteristics of waterproof failure and optimal width of narrow coal pillars under the coupled effects of mining, excavation and seepage
Authors: Chen Dingchao , Wang Xiangyu , Bai Jianbiao , Li Menglong 
Published: June 2024

AbstractThe failure of waterproof coal pillars under the coupled effects of mining, excavation and water seepage is a significant factor contributing to sudden water inflow accidents in underground roadways. Investigating the instability characteristics and optimal width of waterproof coal pillars holds vital significance for water control and resource protection in mines. This study focus on the rational width of waterproof coal pillar at Dongzhuang Coal Mine in Shanxi Province. Using FLAC3D, a fluid–structure interaction numerical model of waterproof coal pillar was established, revealing the coupling characteristics of stress fields, plastic zones, and seepage zones within coal pillars under the influence of mining, excavation and water infiltration weakening. Furthermore, the stability characteristics of waterproof coal pillars with different widths were compared. The results are as follows: (1) Under the combined action of overlying strata pressure and water pressure from the gob, the coal mass on the water-inflow side of coal pillar is the first to fail. Additionally, with the infiltration of water, the elastic modulus, cohesion, and friction angle of the coal mass in the seepage zone decrease. (2) The lifecycle of waterproof coal pillar can be divided into three stages: working face mining, water infiltration from the gob, and roadway excavation. Based on this, the connectivity between plastic zones and seepage zones serves as the critical condition for the stability of waterproof coal pillar was proposed. (3) When the width of waterproof coal pillar is 3 m and 5 m, plastic zones become connected, forming a water-conducting channel. When the width of waterproof coal pillar is 7 m, 9 m, and 11 m, seepage zones and plastic zones are not connected, and the coal pillar exhibits load-bearing and water-barrier properties.
Primitive algebraic points on curves
Authors: Khawaja Maleeha , Siksek Samir 
Published: June 2024

AbstractA number field K is primitive if K and $$\mathbb {Q}$$
Q
are the only subextensions of K. Let C be a curve defined over $$\mathbb {Q}$$
Q
. We call an algebraic point $$P\in C(\overline{\mathbb {Q}})$$

P
∈
C
(

Q
¯

)

primitive if the number field $$\mathbb {Q}(P)$$

Q
(
P
)

is primitive. We present several sets of sufficient conditions for a curve C to have finitely many primitive points of a given degree d. For example, let $$C/\mathbb {Q}$$

C
/
Q

be a hyperelliptic curve of genus g, and let $$3 \le d \le g-1$$

3
≤
d
≤
g
-
1

. Suppose that the Jacobian J of C is simple. We show that C has only finitely many primitive degree d points, and in particular it has only finitely many degree d points with Galois group $$S_d$$

S
d

or $$A_d$$

A
d

. However, for any even $$d \ge 4$$

d
≥
4

, a hyperelliptic curve $$C/\mathbb {Q}$$

C
/
Q

has infinitely many imprimitive degree d points whose Galois group is a subgroup of $$S_2 \wr S_{d/2}$$

S
2

≀

S

d
/
2

.
Systematic review turning existing Egyptian residential buildings in green ones
Authors: Nassar Ayman , Abufarha Ali Gamal Elhosieny 
Published: June 2024

AbstractDue to the continuous technological advancements, expensive utility bills became a major concern for the world residents as well as governments. As a result, energy consumption mitigation became a prominent target for modern researchers. Consequently, solutions were introduced, suggesting that green principles be applied to the construction field. However, even if newly built structures became completely green and emitted no harmful emissions, the net emissions of a given city's overall construction would still be in operation, harming and polluting the environment with all their might. Therefore, it is needed to work on the net green score and rather focus on the conversion of existing buildings into green. Using a questionnaire to create a hypothetical typical Egyptian home, this study aims to apply green solutions to existing buildings in Egypt. The questionnaire also tackles other areas of Egyptian society in order to better understand their awareness and understanding of green concepts. The study’s methodology is based on the collective data gathered from other researchers in the field with applied case studies in climates similar to Egypt’s due to its lack of these solutions applications and concepts. The solutions suggested included solar panels as a retrofitting solution, and windows orientation and window-to-wall ratio (WRR) as a renovating one. As a result, the "windows" solutions suggested in this paper happened to be the most effective.
Extending the concepts of response spectrum analysis to nonlinear static analysis: Does it make sense?
Authors: Ruggieri Sergio , Uva Giuseppina 
Published: June 2024

AbstractThe study presented in this paper aims to assess the recent novelties proposed by new generation building codes about the extension of some concepts at the base of linear analyses to the procedures of nonlinear static analysis. The nonlinear static analysis (pushover) is an extensively adopted approach by engineers and practitioners for purpose of assessing the seismic performance of new and existing buildings, although several drawbacks characterize this methodology, as evidenced by the existing scientific literature. In order to overcome the well-known limitations characterizing nonlinear static analysis, and to offer an alternative to nonlinear dynamic analysis, the recent upgrades of some building codes, such as the Italian one, provide different rules to employ in nonlinear static procedures. Among these new provisions, one regards the possibility to use a horizontal load profile proportional to the storey forces derived from a response spectrum analysis in all cases (i.e., also for irregular buildings). The main goal of this study is to demonstrate the reliability of this new load profile when strong irregularities arise. To this scope, the seismic behaviour of a sample of archetype buildings characterized by increasing in-height irregularity was investigated. The sample of buildings was subdivided in two subsets characterized by different design levels, one conceived by considering the prescriptions of the new Italian building code and one designed according to the oldest Italian building code (i.e., without considering anti-seismic details). The sample of buildings, simulating new and existing cases, was firstly modelled and after investigated through nonlinear static analyses by employing both traditional (i.e., inverse triangular- and uniform-like) and new (i.e., derived from response spectrum analysis) load profiles. After, nonlinear dynamic analyses were run, in order to assess the capacity of both traditional and new load profiles to capture the dynamic behaviour of the investigated archetype buildings. The performed analysis campaign demonstrated the efficiency of the new load profile proposed by the code, and the output of the work provided an answer to the main question posed by the authors: does it make sense to extend the concepts of response spectrum analysis to nonlinear static analysis?
Effects of Office-Yoga and Walking at the Workplace to Improve Health and Wellbeing: A Longitudinal Randomized Controlled Trial
Authors: Nath Alexander , Schimmelpfennig Sophia , Konradt Udo 
Published: June 2024

AbstractWorkplace physical activity interventions in office-based settings are considered essential components of occupational health management, aimed at reducing sedentary behavior and its associated adverse effects, while also promoting employees’ health and wellbeing. This study investigates the effectiveness of office-yoga and walking on employees’ prevalence and intensity of musculoskeletal complaints (MSC), as well as on activation, which encompasses vitality and vigilance. Using a three-month longitudinal randomized controlled trial design, 459 office workers from five organizations were randomly assigned to either the office-yoga intervention group, the walking intervention group, or to a waitlist control group. Participants in the intervention groups were instructed to individually engage in brief daily sessions of the prescribed activity at the workplace. Those in the office-yoga group received video tutorials to perform the exercises. Self-reported MSC and activation were assessed weekly. Bayesian structural equation modeling revealed small effects of office-yoga (d = − 0.26) and walking (d = − 0.31) in reducing the prevalence of MSC as well as a program-based effectiveness of walking over office-yoga in reducing the intensity of MSC (d = 0.23). Concerning longitudinal trends, latent growth modeling revealed an intervention-based effectiveness for both office-yoga and walking on prevalence (doffice−yoga = − 0.32; dwalking = − 0.30) and intensity of MSC (doffice−yoga = − 0.42; dwalking = − 0.35). Neither intervention showed improvements in activation. We found no indication of adverse effects of either intervention. While both office-yoga and walking can effectively improve employees’ MSC, our findings suggest that walking is more effective in reducing intensity of MSC compared to office-yoga.
Merkmale der Klassenzusammensetzung und der Unterrichtsgestaltung und die soziale Integration von Schüler*innen mit und ohne sonderpädagogischen Förderbedarf im gemeinsamen Unterricht
Authors: Kohrt Pauline , Gresch Cornelia , Henschel Sofie 
Published: June 2024

ZusammenfassungAktuelle Studien weisen darauf hin, dass Schüler*innen mit sonderpädagogischem Förderbedarf, die an allgemeinen Schulen unterrichtet werden, weniger sozial eingebunden sind als diejenigen ohne sonderpädagogischen Förderbedarf. Theoretisch wird dieser Befund unter anderem auf soziale Vergleichsprozesse und Kontaktmöglichkeiten der Schüler*innen sowie auf den Einfluss der Lehrkräfte durch ihren persönlichen Umgang mit den Schüler*innen zurückgeführt. Eine Schlüsselfunktion wird hierbei dem Unterricht zugesprochen: Dieser kann als soziale Situation betrachtet werden, in der sich die Zusammensetzung und konkrete Unterrichtsgestaltung auch auf die Entstehung sozialer Kontakte und damit die soziale Integration der Schüler*innen auswirken. Mit Daten des IQB-Bildungstrends 2016 (N = 9417) wurde untersucht, ob verschiedene Merkmale der Klassenzusammensetzung und der Unterrichtsgestaltung mit der sozialen Integration der Schüler*innen zusammenhängen und inwiefern sich diese für Schüler*innen mit (n = 899) und ohne (n = 8488) sonderpädagogischen Förderbedarf der Schwerpunkte Lernen, Sprache und emotionale-soziale Entwicklung unterscheiden. Unter Verwendung von Mehrebenenstrukturgleichungsmodellen konnte gezeigt werden, dass sowohl die Klassenführung als auch die konstruktive Unterstützung positiv mit der sozialen Integration von Viertklässler*innen zusammenhängen und sich dies für die konstruktive Unterstützung zwischen Schüler*innen mit und ohne sonderpädagogischen Förderbedarf unterscheidet. Die Studie liefert Hinweise darauf, inwieweit Lehrkräfte durch die Gestaltung ihres Unterrichts neben Lernprozessen auch das soziale Miteinander unterstützen.