bluuebunny/crossref_metadata_2025_split huggingface dataset:
A primary nipple lymphoma diagnosed by a modified fine‐needle aspiration method
Authors: Wang Peng , Yu Xiao‐Meng 
Published: February 2011

AbstractPrimary breast lymphomas are uncommon. All reported primary breast lymphomas were in the breast parenchyma. Here we reported the first case of primary nipple lymphoma in a 76‐year‐old woman initially diagnosed using a modified fine‐needle aspiration method. The aspirated material by this method had yielded adequate material for both cytomorphologic and flow cytometric analysis, as well as for molecular analysis of light chain rearrangement. In smears the atypical lymphocytes were predominantly middle‐sized with irregular nuclei. Scattered large centroblast or immunoblast‐like cells, a few reactive lymphocytes, histocytes, and few plasma cells were also observed. These findings suggested a low‐grade lymphoma that was further confirmed by flow cytometry (CD19+/CD3−, positive for cytoplasmic kappa light chain but negative for lambda light chain) and molecular analysis (monoclonal rearrangement of immunoglobulin kappa chain). Immunohistochemical stains performed on the excised specimen showed that the tumor cells were positive for CD20 and CD79a but negative for cytokeratin, CD3, CD5, CD10, CD23, CD43, CD45RO, bcl‐6, and cyclin‐D1. The Ki‐67 proliferation index was less than 20%. Taking these together, the case was diagnosed as a primary MALT lymphoma of the nipple. FNA usually provides a better cell morphology than tissue sections, but pathologists have to face the sampling error and lack of immunophenotype information when subtyping lymphoma issues using FNA. With the help of flow cytometry and molecular analysis, more and more trials haveproved the accuracy of FNA in diagnosis of lymphomas. Therefore, FNA could play an informative and diagnostic role indiagnosis of lymphoma. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Primer and interviews: The dynamic stem cell niche
Authors: Kiefer Julie C. 
Published: February 2011

AbstractA stem cell niche is a microenvironment that supports self‐renewal of a population of stem cells, and their production of differentiated cells. While the definition evokes images of a stem cell Shangri‐La—where a serene stem cell pool nestles within a niche that shelters and sustains it—the reality is much more tumultuous. Niches are subject to an ever‐changing maelstrom of environmental factors, the ravages of old age, and the sly tactics of disease. Presented here is a basic overview of the different ways in which stem cell niches respond to local and systemic environments, and their impact on stem cell behavior. The primer culminates with a discussion of the topic with stem cell and niche biologists D. Leanne Jones, Ph.D., and Tudorita Tumbar, Ph.D. Developmental Dynamics 240:737–743, 2011. © 2011 Wiley‐Liss, Inc.
Examining the interpersonal model of binge eating and loss of control over eating in women
Authors: Ansell Emily B. , Grilo Carlos M. , White Marney A. 
Published: February 2011

AbstractObjective:This study examined the interpersonal model of binge eating (Wilfley et al., Interpersonal Psychotherapy for Group, New York: Basic Books, 2000; Wilfley et al., Arch Gen Psychiatry, 8, 713–721, 2002; Elliott et al., Behav Res Ther, 48, 424–428, 2010) which posits that interpersonal problems lead to negative affect which, in turn, triggers disordered eating.Method:The model was tested using data from 350 women obtained via an internet assessment method. Analyses examined direct and indirect effects, via depressive/negative affect, of interpersonal problems, including domains of affiliation and dominance on loss of control over eating, binge eating, and eating disorder psychopathology.Results:Interpersonal problems showed significant effects on binge eating and eating disorder psychopathology that were statistically mediated by depressive/negative affect. Affiliation showed significant effects on binge eating and eating disorder psychopathology with low affiliation effects statistically mediated by depressive/negative affect and high affiliation effects independent of depressive/negative affect.Discussion:These findings support the interpersonal model of binge eating and highlight the importance of examining specific types of interpersonal problems in understanding heterogeneity of individuals with eating disorder psychopathology. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Seasonal patterns of birth for subjects with bulimia nervosa, binge eating, and purging: Results from the National Women's Study
Authors: Brewerton Timothy D. , Dansky Bonnie S. , O'Neil Patrick M. , Kilpatrick Dean G. 
Published: February 2011

AbstractObjective:Studies of birth patterns in anorexia nervosa have shown relative increases between March and August, while studies in Bulimia Nervosa (BN) have been negative. Since there are no studies using representative, nonclinical samples, we looked for seasonal birth patterns in women with BN and in those who ever endorsed bingeing or purging.Method:A national, representative sample of 3,006 adult women completed structured telephone interviews including screenings for bulimia nervosa (BN) and questions about month, date, and year of birth. Season of birth was calculated using traditional definitions. Differences across season of birth between subjects with (n = 85) and without BN (n = 2,898), those with (n = 749) and without bingeing (n = 2,229), and those with (n = 267) and without any purging (n = 2,715) were compared using chi‐square analyses.Results:There were significant differences across season of birth between subjects: (1) with and without BN (p = 0.033); (2) with and without bingeing (p = 0.034), and; (3) with and without purging (p = 0.001). Fall had the highest relative number of births for all categories, while spring had the lowest.Discussion:In a national representative study of nontreatment seeking subjects significant differences in season of birth were found for subjects with lifetime histories of BN, binge eating and purging. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
The myths of motivation: Time for a fresh look at some received wisdom in the eating disorders?
Authors: Waller Glenn 
Published: February 2011

AbstractThe eating disorders typically involve poor motivation to change. This article reviews the evidence behind many of our beliefs about motivation and whether we need a different conceptual framework for understanding why patients commonly get “stuck.” The outcome literature is reviewed, and demonstrates that there is little evidence that we are effective in enhancing motivation to induce changes in symptoms. Indeed, there are suggestions that commonly used models are unhelpful. Verbal expressions of motivation are not the best indicator of likely treatment response, and can best be understood as providing a “manifesto,” which has functions that can obstruct recovery from the eating disorder. A behavioral analysis of motivation is likely to be more effective. Cognitive, emotional, and behavioral methods for enhancing motivation are outlined, with the aim of bypassing the motivational manifesto and encouraging positive therapeutic change. © 2011 by Wiley Periodicals,Inc. (Int J Eat Disord 2012)
The prevalence of irritable bowel syndrome in outpatients with bulimia nervosa
Authors: DeJong Hannah , Perkins Sarah , Grover Miriam , Schmidt Ulrike 
Published: February 2011

AbstractObjective:This study examined the prevalence of irritable bowel syndrome (IBS) in patients with bulimia nervosa (BN), and the relationship between these disorders.Method:Sixty‐four participants with a diagnosis of BN or a related condition were recruited from an outpatient eating disorders service. Questionnaire and interview measures were used to assess bulimic symptoms and attitudes, IBS symptoms, anxiety and depression. Cases of IBS were identified using the Manning criteria.Results:There was a high prevalence of IBS in the patient group (68.8%), but IBS status was not predicted by any of the other variables measured. Patients who met criteria for IBS reported more frequent self‐induced vomiting than those who did not (U = 256.0, p = 0.038).Discussion:There is evidence of an high incidence of IBS in outpatients with BN, but the relationship between these conditions remains unclear. Future research should consider possible common risk factors. © 2011 by Wiley Periodicals, Inc.
Compulsive exercise: The role of personality, psychological morbidity, and disordered eating
Authors: Goodwin Huw , Haycraft Emma , Willis Anne‐Marie , Meyer Caroline 
Published: February 2011

AbstractObjective:Compulsive exercise has been closely linked with eating disorders, and has been widely reported in both clinical and nonclinical settings. It has been shown to have a negative impact on eating disorder treatment and outcome. However, the risk factors for compulsive exercise have not been examined. This study aimed to provide a first step in identifying potential cross‐sectional predictors of compulsive exercise.Method:The sample consisted of 1,488 male and female adolescents, aged 12–14 years old, recruited from schools in the United Kingdom. Participants completed measures of compulsive exercise, personality, psychological morbidity, and disordered eating attitudes during a school class period.Results:Multiple stepwise regressions showed that the strongest cross‐sectional predictors of compulsive exercise were a drive for thinness, perfectionism, and obsessive‐compulsiveness.Discussion:These results are discussed in terms of the role that personal factors may play in the development of compulsive exercise. © 2011 by Wiley Periodicals, Inc.
Binge eating disorder psychopathology in normal weight and obese individuals
Authors: Dingemans Alexandra E. , van Furth Eric F. 
Published: February 2011

AbstractObjective:Although Binge Eating Disorder (BED) is associated with obesity and unstable weight and the diagnosis was originally predicated with the obese in mind, obesity is not a criterion for BED. In fact, BED is not uncommon in nonobese individuals. The aim of this study was to compare the psychopathology of obese (BMI >30) and nonobese individuals (BMI < 30) with BED.Method:Within a group of 174 individuals diagnosed with BED, 51 (29%) were classified as nonobese and 123 (71%) as obese. The Eating Disorder Examination (EDE) and Beck Depression Inventory (BDI) were administered to assess eating disorder psychopathology and depressive symptoms.Results:The nonobese BED group was significantly younger and was less likely to receive treatment. The obese group had more concerns about weight and reported more objective binge eating episodes. No differences were found on any other subscales of the EDE or BDI.Discussion:Our main finding was that there are more similarities than differences between the nonobese and obese individuals with BED. The severity of the psychopathology does not seem to be related to BMI. More awareness of the existence of nonobese individuals with BED is needed. Early detection and treatment may prevent the development of overweight and it's consequences. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Respiratory acidosis in adolescents with anorexia nervosa hospitalized for medical stabilization: A retrospective study
Authors: Kerem Nogah C. , Riskin Arieh , Averin Elvira , Srugo Isaac , Kugelman Amir 
Published: February 2011

AbstractObjective:To examine the effect of malnutrition due to anorexia nervosa (AN) on venous blood gases of adolescents with AN hospitalized for medical stabilization.Method:This retrospective study included 45 adolescents with recent onset (<1 year) AN diagnosed by DSM‐IV criteria and excluded subjects with a history of lung disease.Results:Mean (±SD) age at hospitalization was 15.0 ± 2.0 years; time from onset of symptoms was 6.8 ± 3.0 months; body mass index (BMI) was 15.2 ± 1.5 kg/m2; and minimal nocturnal heart rate (MNHR) was 39.8 ± 7.2 beats/min. On admission, pH was 7.32 ± 0.02, pCO2 was 53.8 ± 4.6 mm Hg, and HCO3 was 28.1 ± 2.1 mEq/l. Significant changes (p < .001) occurred during the relatively short hospitalization (9.7 ± 5.1days): venous pH increased, pCO2 decreased, HCO3 decreased, MNHR increased, and heart rate orthostasis decreased. Mild respiratory acidosis (pH < 7.35 and pCO2 > 45 mm Hg) was observed in 78% of the patients on admission and only in 35% at discharge (p = .0003). Positive correlations were found between % of weight loss and pCO2 on admission and between BMI on admission and the delta pCO2 during hospitalization.Discussion:Mild respiratory acidosis is common in adolescents with recently diagnosed AN, hospitalized for medical stabilization. Respiratory acidosis improves with bed rest and refeeding. The clinical significance of these findings should be further evaluated. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
The therapeutic alliance in the early part of cognitive‐behavioral therapy for the eating disorders
Authors: Waller Glenn , Evans Jane , Stringer Hannah 
Published: February 2011

AbstractObjective:This study examined the strength of the therapeutic alliance in the early stages of cognitive‐behavioral therapy (CBT) for the eating disorders, and whether the strength of that allianceis associated with early eating characteristics, comorbid Axis 1 and 2 features.Method:Forty‐four eating‐disordered patients completed measures of eating and Axis 1 and 2 characteristics at the start of therapy, and measures of the therapeutic alliance and eating characteristics at the sixth session of CBT.Results:The therapeutic alliance was strong, including in the domain of attachment. It was unrelated to initial eating pathology and early changes in eating cognitions and behaviors. However, there were links between initial emotional and interpersonal features and therapeutic alliance by the sixth session.Discussion:The findings counter suggestions that CBT for eating disorders is characterized by a poor therapeutic relationship. The therapeutic alliance is likely to be enhanced by addressing high levels of emotional distress and difficulties in interpersonal function where appropriate. This research needs to be extended to other therapies, other domains of function and different time points in therapy, to build a fuller picture of the role of the therapeutic relationship in working with the eating disorders. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
“Do you still want to be seen?”: The pros and cons of active waiting list management
Authors: Tatham Madeleine , Stringer Hannah , Perera Samanthi , Waller Glenn 
Published: February 2011

AbstractObjective:This study examined the impact on a clinic waiting list of introducing an “opt‐in” system for patients awaiting individual outpatient cognitive behavioral therapy. The proportion of patients opting in was identified, along with demographic, eating, and psychopathological factors that might make some more likely to opt out.Method:The sample consisted of 116 patients with eating disorder. Each completed measures of eating and axis 1 and 2 characteristics at assessment. They received one opt‐in letter and a reminder. Those who opted in immediately or after a reminder were compared with those who did not.Results:Just over two‐thirds of the patients opted to remain on the waiting list. No demographic or eating characteristics differentiated those individuals. Those who did not opt in immediately had higher levels of depression, psychoticism, and borderline personality disorder cognitions. However, that difference disappeared when the reminder letter was sent.Discussion:Waiting list reductions can be achieved through an active “opt‐in” mechanism, and this approach does not disadvantage specific individuals but speeds access to treatment for the majority of patients. However, further research is needed to track pathways of care to determine whether such initiatives have longer term positive or negative impacts. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)
Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands
Authors: Magalhaes Joao G. , Lee Jooeun , Geddes Kaoru , Rubino Stephen , Philpott Dana J. , Girardin Stephen E. 
Published: February 2011

AbstractMuramyl peptides are the building blocks of bacterial peptidoglycan, and their biological functions in mammals have been extensively studied. In particular, muramyl peptides trigger inflammation, contribute to host defense against microbial infections, and modulate the adaptive immune response to antigens. These bacterial molecules are detected by nucleotide oligomerization domain 1 (Nod1) and Nod2, and recent evidence suggests that muramyl dipeptide also activates NLRP3 and NLRP1 inflammasomes. Here, we investigated the role of Rip2, the adaptor for Nod1‐ and Nod2‐dependent signaling, in multiple aspects of the host response to muramyl peptides in vivo, such as inflammatory cytokine secretion, activation and recruitment of macrophages and neutrophils to the site of injection, systemic activation of myeloid, T and B cells in the spleen, adjuvanticity and capacity to polarize the adaptive response to ovalbumin. Our results demonstrate that Rip2 was crucial for all the biological functions studied. We also identified CD11cintCD11b+ inflammatory dendritic cells as a major myeloid cell population responding to Nod stimulation in vivo. Together, our results highlight the importance of Rip2 for Nod‐dependent induction of innate and adaptive immunity.
ER stress and its regulator X‐box‐binding protein‐1 enhance polyIC‐induced innate immune response in dendritic cells
Authors: Hu Fanlei , Yu Xiaofei , Wang Hongxia , Zuo Daming , Guo Chunqing , Yi Huanfa , Tirosh Boaz , Subjeck John R. , Qiu Xiaoyan , Wang Xiang‐Yang 
Published: February 2011

AbstractMultiple physiological and pathological conditions interfere with the function of the endoplasmic reticulum (ER). However, much remains unknown regarding the impact of ER stress on inflammatory responses in dentritic cells (DCs) upon the recognition of pathogen molecules. We show that ER stress greatly potentiates the expression of inflammatory cytokines and IFN‐β in murine DCs stimulated by polyIC, a synthetic mimic of virus dsRNA. Both toll‐like receptor 3 and melanoma differentiation‐associated gene‐5 are involved in the enhanced IFN‐β production, which is associated with increased activation of NF‐κB and IRF3 signaling as well as the splicing of X‐box‐binding protein‐1 (XBP‐1), an important regulator involved in ER stress response. Surprisingly, silencing of XBP‐1 reduces polyIC‐stimulated IFN‐β expression in the presence or absence of ER stress, indicating that XBP‐1 may be essential for polyIC signaling and ER stress‐amplified IFN‐β production. Overexpression of a spliced form of XBP‐1 (XBP‐1s) synergistically augments polyIC‐induced inflammatory response. For the first time, we show that XBP‐1s overexpression‐enhanced IFN‐β production in DCs markedly suppresses vesicular stomatitis virus infection, revealing a previously unrecognized role for XBP‐1 in an antiviral response. Our findings suggest that evolutionarily conserved ER stress response and XBP‐1 may function collaboratively with innate immunity to maintain cellular homeostasis.
Leishmania donovani glycosphingolipid facilitates antigen presentation by inducing relocation of CD1d into lipid rafts in infected macrophages
Authors: Karmakar Subir , Paul Joydeep , De Tripti 
Published: February 2011

AbstractNKT cells respond to presentation of specific glycolipids with release of both Th1‐ and Th2‐type cytokines. Leishmania donovani (LD)‐infected splenic macrophages (sMϕ(I)) and bone marrow‐derived dendritic cells (BMDC(I)) failed to activate NKT cells in response to α‐galactosyl ceramide (α‐GalCer). The defective antigen presentation could be corrected by treating the cells with the immunostimulating glycosphingophospholipid (GSPL) of LD parasites. In vitro pulsing of BMDC(I) or sMϕ(I) with GSPL, caused the activation of the Vα14+ CD1d1‐specific NKT cell hybridoma DN32.D3. Localization of MHC II and CD1d molecules to membrane lipid rafts has been suggested to play an important role in antigen presentation. Confocal analysis clearly demonstrated that LD infection changed the pattern of CD1d distribution to the non‐lipid raft regions and this change could be reversed by GSPL treatment. Isoelectric focusing gel shift assay indicated that GSPL binds to CD1d. GSPL‐treated but not untreated BMDC(I) formed immune synapses with NKT cells and this was associated with calcium mobilization. In conclusion, GSPL treatment was associated with modification of BMDC(I)/sMϕ(I) lipid raft structure, which is a site for immune regulation.
Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg
Authors: Schmidl Christian , Hansmann Leo , Andreesen Reinhard , Edinger Matthias , Hoffmann Petra , Rehli Michael 
Published: February 2011

AbstractThe adoptive transfer of in vitro expanded Treg is a promising treatment option for autoimmune as well as alloantigen‐induced diseases. Yet, concerns about the phenotypic and functional stability of Tregs upon in vitro culture command both careful selection of the starting population and thorough characterization of the final cell product. Recently, a high degree of developmental plasticity has been described for murine Treg and Th17 cells. Similarly, IL‐17‐producing FOXP3+ cells have been detected among the CD45RA− memory‐type subpopulation of human Tregs ex vivo. This prompted us to investigate the predisposition of human naïve and memory Tregs to develop into Th17 cells during polyclonal in vitro expansion. Here, we show that stimulation‐induced DNA demethylation of RORC, which encodes the lineage‐defining transcription factor for Th17 cells, occurs selectively in CD45RA− memory‐type Tregs, irrespective of their FOXP3 expression level. On the contrary, naïve CD45RA+ Tregs retain stable CpG methylation across the RORC locus even upon prolonged ex vivo expansion and in consequence show only a marginal tendency to express RORC and develop into IL‐17‐producing cells. These findings are highly relevant for the generation of therapeutic Treg products.
Novel Metal‐Organic Frameworks Incorporating [Cp°2Mo2P4S] (Cp° = 1‐tBu‐3,4‐Me2C5H2), P4S3 and Cu2I2 Building Blocks (Eur. J. Inorg. Chem. 6/2011)
Authors: Gröger Christian , Kalbitzer Hans Robert , Pronold Michael , Piryazev Dmitry , Scheer Manfred , Wachter Joachim , Virovets Alexander , Zabel Manfred 
Published: February 2011

AbstractThe cover picture shows the porous metal‐organic polymer [(Cp°2Mo2P4S)CuI)4]n, which is composed of helical substructures with opposite handedness. The compound incorporates CH2Cl2 molecules when it is stored under the solvent. This process is reversible under high vacuum without loss of crystallinity of the material and resembles, therefore, the reversible stretching of an elastic spring. Details of the synthesis and characterization of this and related compounds are given in the article by J. Wachter et al. on p. 785 ff.
Synthetic Studies towards Pectenotoxin‐2: Synthesis of the Nonanomeric 10‐epi‐ABCDE Ring Segment by Kinetic Spiroketalization
Authors: Aho Jatta E. , Piisola Antti , Syam Krishnan K. , Pihko Petri M. 
Published: February 2011

AbstractThe synthesis of the nonanomeric 10‐epi‐ABCDE ring system of pectenotoxin‐2 has been achieved by using a kinetic spiroketalization reaction. The synthesis of the spiroketalization precursor was achieved through a cross‐metathesis/hydrogenation sequence. The formation of the epi‐C10 isomer resulted from an unexpected anti‐Felkin selective addition of organometallic nucleophiles to the advanced CDE ring precursor. This addition reaction was investigated with differently protected α,β‐dioxygenated model aldehydes, which displayed similar anti‐Felkin selectivities with organometallic nucleophiles.