bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advances of Oxidative Stress Impact in Periodontitis: Biomarkers and Effective Targeting Options
Authors: Pouliou Chrysi , Piperi Christina 
Published: May 2024

:
Periodontitis is the most common inflammatory oral disease that affects
around 15% of adults and contributes to severe periodontal tissue destruction with subsequent
tooth loosening and loss. Among the main pathogenic mechanisms underlying periodontitis,
excessive reactive oxygen species production and oxidative stress play a predominant
role in inducing both local and systemic damage. Current therapeutic approaches
have expanded the conventional methods combined with herbal antioxidant
compounds to free radical-scavenging nanomaterials and infrared laser therapy, offering
promising pre-clinical evidence in periodontitis management. Herein, we review the
pathogenic mechanisms of reactive oxygen species tissue damage, along with recent advances
in oxidative stress biomarkers and novel targeting options.
Polyphyllin I Mitigated IL-1β-Induced Chondrocytes Damage through Downregulating TWIST1 Expression
Authors: Liu Feng , Han Bowen , Yang Deshun , Ji Xiaopeng , Yan Liangliang , Han Chaoyong 
Published: May 2024

Background:
Osteoarthritis (OA) is a chronic joint disease characterized by
the degradation of articular cartilage. Polyphyllin I (PPI) has anti-inflammatory effects
in many diseases. However, the mechanism of PPI in OA remains unclear.

Methods:
HC-a cells treated with IL-1β were identified by immunofluorescence
staining and microscopic observation. The expression of collagen II and DAPI in HC-a
cells was detected by immunofluorescence. The effects of gradient concentration of
PPI on IL-1β-induced cell viability, apoptosis, senescence, and inflammatory factor
release were detected by MTT, flow cytometry, SA-β-Gal assay and ELISA,
respectively. Expressions of apoptosis-related genes, extracellular matrix (ECM)-
related genes, and TWIST1 were determined by qRT-PCR and western blot as
needed. The above-mentioned experiments were conducted again after TWIST1
overexpression in IL-1β-induced chondrocytes.

Results:
IL-1β reduced the number of chondrocytes and the density of collagen II. PPI
(0.25, 0.5, 1 μmol/L) had no effect on cell viability, but it dose-dependently elevated the
inhibition of cell viability regulated by IL-1β. The elevation of cell apoptosis,
senescence and expression of IL-6 and TNF-α were suppressed by PPI in a dosedependent
manner. Additionally, PPI reduced the expression of cleaved caspase-3,
bax, MMP-3, and MMP-13 and promoted the expression of collagen II. TWIST1
expression was diminished by PPI. TWIST1 overexpression reversed the abovementioned
effects of PPI on chondrocytes.

Conclusion:
PPI suppressed apoptosis, senescence, inflammation, and ECM
degradation of OA chondrocytes by downregulating the expression of TWIST1.
PPARs (Peroxisome Proliferator-activated Receptors) and Their Agonists in Alzheimer's Disease
Authors: Kumar Mohit , Sharma Anita Ashok , Datusalia Ashok Kumar , Khatik Gopal L. 
Published: May 2024

:
Alzheimer's disease (AD) is a neurodegenerative disease leading to dementia because of
complex phathomechanisms like amyloid β (Aβ) aggregation, tau aggregates, and neurofibrillary
tangles. Peroxisome proliferator-activated receptor (PPAR) agonists have been reported recently
with neuroprotective and anti-inflammatory properties. PPARs belong to the superfamily of nuclear
hormone receptors and function as ligand-activated transcription factors. These have emerged as
crucial players in the pathogenesis of AD. This review presented the potential of PPARs and their
agonists in treating neurodegenerative diseases like AD.

:
PPARs regulate the expression of specific genes vital for synaptic function and neurotransmitter
release. PPAR agonists play a critical role in increasing the clearance of Aβ peptides by lowdensity
lipoprotein receptor-related protein 1 (LRP1) in the microvascular endothelial cells of the
human brain. Studies have shown that PPAR agonists reduce the level of APoE-mRNA, contributing
to the accumulation of Aβ plaques and up-regulation of PPAR. A knockout of miR-128 has
been found to inhibit AD-like cognitive decline, amyloid precursor protein (APP) amyloidogenic
processing, and inflammatory responses in AD.

:
PPARs are involved in the pathomechanism of AD, and therefore, PPAR agonists could be viable
options for controlling the neurodegenerative symptoms and may be useful in treating AD.
Stem Cell Markers in Neoplasms and their Relationship with Progression-free and Overall Survival in Patients with Recurrence
Authors: Eguiluz-Melendez Aldo , Rubio-Osornio Carmen , Rosiles-Abonce Artemio , Mendoza Cesar , Ramírez-Ordás Miryam , Rivera-Cañas Romina , Tena-Suck Martha , Gómez-Amador Juan Luis , Moreno-Jimenez Sergio 
Published: May 2024

Background:
Gliomas account for 30% of primary brain tumors in adults, and despite
the scientific progress in the field, recurrence is prevalent. Glioma Stem Cells (GSCs) can generate
tumor cells in vivo and in vitro and they are associated with treatment resistance, tumor progression,
and recurrence. Furthermore, the expression of SOX transcription factors (SOX1, SOX2,
SOX9) in these cells is responsible for maintaining an oncogenic genotype and is associated with
an aggressive tumor phenotype. The relationship between SOX transcription factors and their prognostic
role in recurrent gliomas has not been described in detail. Therefore, we set out to describe
the relationship between SOX expression and Progression-free Survival (PFS) and Overall Survival
(OS) in patients with recurrent gliomas.

Methods:
In this observational study, we have retrospectively analyzed 69 patients, of which 20
met the inclusion criteria. The clinical, radiological, and histopathological findings have been described,
and survival analysis has been performed according to SOX expression for PFS and OS.

Results:
We found SOX1, SOX2, and SOX9 to show a non-statistically significant trend with increasing
histopathological grade, co-expressed with Ki67, a cell proliferation factor.

Conclusion:
There has been found an inversely proportional correlation between the degree of immunopositivity
of SOX1 and OS. A higher SOX1 immunopositivity could predict a worse clinical
prognosis. There has also been found an interaction between a pluripotent genotype (GSC) and
cell proliferation.
Smart Multifunctional Nanoparticles in Cancer Theranostics: Progress and Prospect
Authors: Karati Dipanjan , Mukherjee Swarupananda , Dutta Ayon , Ash Dipanjana , Ganguly Shayeri Chatterjee , Acharya Apurbaa , Basu Biswajit 
Published: May 2024

Background:
Worldwide, cancer is the second most common cause of death. Chemotherapy
and other traditional cancer treatments have toxicities that affect normal cells in addition to
their intended targets, necessitating the development of novel approaches to enhance cell-specific
targeting.

Methods:
The present work summarizes the scientific information on nanoparticles in cancer
theranostics to provide a comprehensive insight into the preventive and therapeutic potential of nanoparticles
in cancer. Scopus, PubMed, Science Direct, and Google Scholar databases are searched
to collect all the recent (2015-2023) scientific information on smart multifunctional nanoparticles
using the terms nanotechnology, cancer theranostics, and polymer.

Results:
The use of nanomaterials as chemical biology tools in cancer theranostics has been thoroughly
investigated. They demonstrate expanded uses in terms of stability, biocompatibility, and
enhanced cell permeability, enabling precision targeting and ameliorating the drawbacks of conventional
cancer treatments. The nano platform presents a fascinating chance to acquire multifunctionality
and targeting techniques. The production of smart nanomaterials, specifically with regard to
the advent of nanotechnology, has revolutionized the diagnosis and treatment of cancer. The capability
of nanoparticles to functionalize with a variety of biosubstrates, including aptamers, antibodies,
DNA, and RNA, and their broad surface area allow them to encapsulate a huge number of molecules,
contributing to their theranostic effect. Comparatively speaking, economical, easily produced,
and less toxic nanomaterials formed from biological sources are thought to have benefits
over those made using conventional processes.

Conclusion:
The present study highlights the uses of several nanoparticles (NPs), and describes
numerous cancer theranostics methodologies. The benefits and difficulties preventing their adoption
in cancer treatment and diagnostic applications are also critically reviewed. The use of smart nanomaterials,
according to this review's findings, can considerably advance cancer theranostics and
open up new avenues for tumor detection and treatment.
A Comparative Analysis of Machine Learning Models for the Classification of Heart Failure Patients in the Intensive Care Unit
Authors: Gaudin Mateo , Kaur Swapandeep , Sharma Preeti , Kumar Rajeev 
Published: May 2024

Background:
Heart failure is the leading cause of death globally over the last several
decades. This raises the necessity of timely, accurate, and prudent methods for establishing an
early diagnosis and implementing timely illness care.

Objective:
This study aims to develop and validate a classification model for the patients admitted
to the Intensive Care Unit (ICU) with heart failure, using various machine learning models applied
to the MIMIC (Medical Information Mart for Intensive Care)-III database.

Method:
A retrospective cohort study was conducted using data extracted from the MIMIC-III
database. Machine learning models: Logistic Regression, K-Nearest Neighbor (KNN), Random
Forest, Decision Tree, Naïve Bayes, AdaBoost, and XGBoost were utilized to construct the predictive
model. The dataset has been preprocessed in two different manners. The study included
1,177 patients with heart failure, selected according to specific inclusion/exclusion criteria and
admitted to the ICU.

Result:
At the end of the study, the most effective model for predicting patients who survived was
Logistic Regression, with an accuracy of 0.9025, sensitivity of 0.9763, precision of 0.9196, and
F1-score of 0.9471.

Conclusion:
Classification of the patients into those who survived or could not survive due to
heart failure was the primary measure, with various clinical and demographic variables used as
predictors.
Spanish and Catalan Versions of the eHealth Literacy Questionnaire: Translation, Cross-Cultural Adaptation, and Validation Study
Authors: Hernández Encuentra Eulàlia , Robles Noemí , Angulo-Brunet Ariadna , Cullen David , del Arco Ignacio 
Published: May 2024

Background
The rise of digital health services, especially following the outbreak of COVID-19, has led to a need for health literacy policies that respond to people’s needs. Spain is a country with a highly developed digital health infrastructure, but there are currently no tools available to measure digital health literacy fully. A well-thought-through questionnaire with strong psychometric properties such as the eHealth Literacy Questionnaire (eHLQ) is important to assess people’s eHealth literacy levels, especially in the context of a fast-growing field such as digital health.

Objective
This study aims to adapt the eHLQ and gather evidence of its psychometric quality in 2 of Spain’s official languages: Spanish and Catalan.

Methods
A systematic cultural adaptation process was followed. Data from Spanish-speaking (n=400) and Catalan-speaking (n=400) people were collected. Confirmatory factor analysis was used to confirm the previously established factor structure. For reliability, the Cronbach α and categorical ω were obtained for every subscale. Evidence of convergent and discriminant validity was provided through the correlation with the total score of the eHealth Literacy Scale. Evidence based on relations to other variables was evaluated by examining extreme values for educational level, socioeconomic level, and use of technology variables.

Results
Regarding the confirmatory factor analysis, the 7-factor correlated model and the 7 one-factor models had adequate goodness-of-fit indexes for both Spanish and Catalan. Moreover, measurement invariance was established between the Spanish and Catalan versions. Reliability estimates were considered adequate as all the scales in both versions had values of >0.80. For convergent and discriminant validity evidence, the eHealth Literacy Scale showed moderate correlation with eHLQ scales in both versions (Spanish: range 0.57-0.76 and P<.001; Catalan: range 0.41-0.64 and P<.001). According to the relationship with external variables, all the eHLQ scales in both languages could discriminate between the maximum and minimum categories in level of education, socioeconomic level, and level of technology use.

Conclusions
The Spanish and Catalan versions of the eHLQ appear to be psychometrically sound questionnaires for assessing digital health literacy. They could both be useful tools in Spain and Catalonia for researchers, policy makers, and health service managers to explore people’s needs, skills, and competencies and provide interesting insights into their interactions and engagement regarding their own experiences with digital health services, especially in the context of digital health growth in Spain.
OSMOTIC DRUG DELIVERY SYSTEM OF NICORANDIL: DESIGN AND EVALUATION
Authors: CHOUDHARY SRILATHA , SUBRAHMANYAM CVS , PRIYANKA K. 
Published: May 2024

Objective: The purpose of the current research was to design a nicorandil formulation with controlled drug release using the principles of osmotic pump technology. Nicorandil is a biopharmaceutical classification system (BCS) class 3 drug, having a shorter plasma elimination half-life and bioavailability of 75 to 80%.
Methods: The elementary osmotic pump (EOP) was prepared by coating a cellulose acetate polymer on the prepared core tablet. A 24-factorial design was applied to optimize the parameters for the osmotic tablet. A surface orifice was drilled.
Results: Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) results showed that there was no interaction between drugs and excipients. A 24-factorial design was applied to optimize the parameters for the elementary osmotic pump. The optimized batch was characterized for in vitro drug release studies, and the effects of pH, osmotic pressure, and agitation intensity were analyzed. All the batches showed a drug release ranging from 90.48% to 98.78% after 12 hours. There was no change in the drug release pattern at different pHs and agitation intensities. The drug release was found to decrease with the increasing osmotic pressure of the dissolution medium. The results showed that the amounts of sodium chloride and mannitol were positively affecting the drug release, while the plasticizers PEG400 and DBP were not critical. Scanning electron microscopic studies (SEM) showed the integrity and surface morphology of the coating membrane before and after dissolution. The prepared EOP was found to deliver nicorandil at zero-order for up to 12 hours.
Conclusion: Nicorandil was developed successfully as a controlled drug delivery during a 12-hour period, with variables optimized by the use of a 24-factorial design.
Influence of Invisalign precision bite ramp utilization on deep bite correction and root length in adults
Authors: Husain Fatemah , Warunek Stephen , Gurav Ashish , Giangreco Terry , Tanberg William , Al-Jewair Thikriat 
Published: May 2024

ABSTRACT

Objectives
To assess the influence of Invisalign precision bite ramp use on skeletal deep overbite correction and root length and volume of maxillary anterior teeth.

Materials and Methods
This was a retrospective study of 60 adults with skeletal deep overbite. Patients were divided into three groups: Invisalign (Align Technology, San Jose, Calif) with precision bite ramps (Invisalign with Bite Ramps [IBR] = 12), Invisalign with no bite ramps (INBR = 22), and full-fixed appliances (FFA = 26). Cone beam computed tomography records at T1 (pretreatment) and T2 (posttreatment) were used to measure eight skeletal, nine dental, and three soft-tissue cephalometric variables. Maxillary anterior teeth root length (mm), root volume (mm3), and percent root volume loss between T1 and T2 (%) were also recorded.

Results
Significant changes from T1 to T2 among the three groups were seen in ANB(o), lower face height (%), ODI (overbite depth indicator) (o), and U1–SN (o). Reduction in root length was significantly less (P &lt; .001) in the INBR and IBR groups compared to the FFA group. Reduction in root volume and percent volume loss were significantly higher in the INBR group compared to the IBR group (P &lt; .001), but the difference between the two Invisalign groups and the FFA group was not significant.

Conclusions
Skeletal deep overbite correction using Invisalign with or without bite ramps is comparable to FFA. Reduction in root length was significantly less with Invisalign compared to FFA. Bite ramps influenced root volume and volume loss but not root length.
Percepções de consumidores em restaurantes Fast Food em Campos dos Goytacazes
Authors: Lima Juliana Damaris Candido de , Araujo Fábio Francisco de , Franca Paula Albuquerque Penna 
Published: May 2024

O setor de serviços tem ganhado relevância na sociedade pós-industrial. Nesse contexto, o setor de serviços alimentício emerge com destaque na economia de vários países. Este trabalho tem como objetivo avaliar a qualidade de serviços em restaurantes fast food a partir do método de análise hierárquica, que facilita a interpretação de priorização em um problema decisório multicritério. Foi utilizado um questionário baseado na ferramenta DINESERV. Por meio de uma análise fatorial, as cinco dimensões originais foram reorganizadas em seis dimensões (critérios): Instalações Físicas, Cardápio, Decoração do ambiente e Aparência dos Funcionários; Confiabilidade; Responsividade, Segurança e Empatia. Os resultados mostram que os fatores que interferiram na preferência escolha dos consumidores são: Cardápio, Decoração do ambiente e Aparência dos Funcionários.
Modification and Innovation of Commode Chair Using a Polyester-based Composite for Elderly Patient
Authors: Sosiati Harini , Wahyono Tri , Hidayatullah Hidayatullah , Muttaqien Arif Rahman , Pamasti Ankas , Wicaksono Ryan Nauval , Ramadhan Rahmat 
Published: May 2024

Bamboo stems, a source of fiber/bamboo salts, is a type of natural fiber with a lower density than other natural fibers. Apus bamboo is a type of bamboo having high mechanical strength. Their superior properties have attracted public interest to develop their potential to become advanced and functional materials. A combination of woven apus bamboo slats obtained from Kalisemo village, Purworejo Regency, Indonesia, and woven glass fiber are used as the reinforcing material and fabricated to be the hybrid composite material with a polyester binder mixed with 5% eggshell powder. The ratio of reinforcement and binder is 20: 80 (vol. %). This composite product is used for modification and innovation components in the commode chair product as a medical device for elderly patients. The flexural strength and water absorption tests are conducted on the composite material before use. The commercial commode chair made of wood is modified using the composite and made an innovation by adding right and left handrails to maintain the body balance of elderly patients. Keywords: (bamboo slat, commode chair, composite, glass fiber, polyester).
La política turística de “sol y cemento” en Mar del Plata en los años setenta y ochenta
Authors: Castellucci Daniela Ivanova 
Published: May 2024

El artículo se centra en el estudio del Complejo balneario de Punta Mogotes (Mar del Plata, Argentina), entendiéndolo como caso paradigmático que permite analizar el entramado de conflictos en torno al dominio, jurisdicción y usufructo de la playa, en los años setenta, por un lado; y, por el otro, estudiar la actuación del municipio frente a los conflictos previos a la construcción y posterior puesta en funcionamiento del complejo, en los años ochenta, y sus implicancias. El trabajo se inscribe en la perspectiva historiográfica de la historia social de la política. Se ha empleado una mirada metodológica interpretativista a través de una triangulación de estrategias cualitativas de recolección y análisis de datos.
En años los sesenta y setenta esta franja costera se convirtió en un espacio de controversias entre los gobiernos provinciales, municipales y los vecinos, en la búsqueda de encontrar un uso que permitiera conciliar el acceso a las playas públicas y disfrute del paisaje con el negocio privado, dado que éste último implicaba una restricción al uso de dichos espacios. Así, este complejo, construido en los ochenta, ofició como catalizador de un proceso en donde se conjugaron múltiples acciones con incidencia en lo espacial, político, económico y social.
National dairy research programs: what is their role in animal health and sustainability research?
Authors: Briggs Kaitlyn R. , Ackermann Mark 
Published: May 2024

Abstract
The US dairy industry has made great strides in improving animal health over many decades, which has driven substantial improvements in economic, social, and environmental sustainability. As consumer and corporate focus on climate continues to grow, the continued need to research and improve animal health and understand its connection with the environment is integral to the success of the dairy industry. Research to address these areas can be supported by national research programs and collaboration between them. The USDA and Dairy Management Inc established a collaborative research agreement in 2007; to date, this collaboration has not explicitly focused on animal health or its intersection with the environment. It is integral to the success of animal agriculture in an ever-changing sustainability landscape that animal health is addressed as a key piece of socioeconomic and environmental sustainability. An academic-industry stakeholder committee reached a consensus that supported this idea and identified that it is equally important to communicate these research findings with consumers in a way that resonates. The purpose of this Viewpoint article is to highlight that national research programs at the USDA Agricultural Research Service’s National Animal Disease Center and Dairy Management Inc can and should play an important role in supporting and facilitating research at the intersection of animal health and sustainability broadly.
Using computer vision and natural language processing technology to understand the narrative plot of children’s picture books
Authors: Jiang Yajuan 
Published: May 2024

Abstract
Computer vision is used for monitoring and classification analysis in today’s society. The monitoring error rate of children’s picture books and the manual efficiency of classification are too slow, so it is difficult to find suitable books in a short time. Computer vision can help monitor and classify children’s picture books based on natural processing techniques. In this paper, the comparison between classical calculation and evolutionary calculation is used to prove that evolutionary calculation has a better accuracy, and the evolutionary calculation is further studied, finally reaching 97.8% accuracy in monitoring. This kind of evolutionary calculation should be vigorously developed in the future.