bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carroll strings with an extended symmetry algebra
Authors: Harksen Matthias , Hidalgo Diego , Sybesma Watse , Thorlacius Lárus 
Published: May 2024

Abstract
Starting from the Polyakov action we consider two distinct Carroll limits in target space, keeping the string worldsheet relativistic. The resulting magnetic and chiral Carroll string models exhibit different symmetries and dynamics. Both models have an infinite dimensional symmetry algebra with Carroll symmetry included in a finite dimensional subalgebra. For the magnetic model, this is the so-called string Carroll algebra. The chiral model realises an extended version of the string Carroll algebra. The magnetic model does not have any transverse string excitations. The chiral model is less restrictive and includes arbitrary left-moving modes that carry transverse momentum but do not contribute to the energy in target space.
Wandel von Nutzen und Risiko antidepressiver Pharmakotherapie
Authors: Baethge Christopher 
Published: May 2024

ZusammenfassungDie antidepressive Pharmakotherapie durchlief in ihrer Geschichte verschiedene Phasen: Der Euphorie der Anfangsjahre über die medikamentöse Erleichterung depressiver Syndrome folgte ein langer Zeitraum klinischer Erfahrung und intensiver wissenschaftlicher Durchdringung, die zu einer abgewogeneren Perspektive führten. Aktuelle Debatten kreisen um die tatsächliche Effektstärke – gerade in Bezug auf lange Behandlungsdauern –, die Prävention von Suiziden und die Folgen des Absetzens eines Antidepressivums. Die Bewertung der Stoffgruppe, aber oft auch das Nutzen-Schaden-Verhältnis einer individuellen Behandlung verändert sich mit der Zeit. Die Antidepressiva stehen exemplarisch für viele psychiatrische Behandlungen, die – in einem Begriff Hanfried Helmchens – ebenso janusköpfig sind wie die Psychiatrie es als Wissenschaft und als klinisches Fach ganz allgemein ist.
The significance of structural components of lignocellulosic biomass on volatile organic compounds presence on biochar - a review
Authors: Syguła Ewa , Ciolkosz Daniel , Białowiec Andrzej 
Published: May 2024

AbstractThe product of thermochemical processing of lignocellulosic biomass is biochar. It has a range of properties that make it suitable for a variety of economic applications. However, during pyrolysis and torrefaction, volatile organic compounds (VOCs) are released and may redeposit on the surface of the biochar. Some of these compounds may be harmful to the environment and humans. Bibliometric study shows that, to date, studies on the release of VOCs from biochar have been of an inventory nature and concerned with specific case studies of the specific types of biomass. To date, there has been no comprehensive and systematic analysis of the influence of lignocellulosic biomass properties and pyrolysis/torrefaction process parameters on VOC formation and redeposition on biochar. In this paper, the analysis is presented of the potential harmfulness of VOCs released during the thermochemical processing of lignocellulosic biomass components, based on cellulose, hemicellulose, and lignin pyrolysis/torrefaction chemistry data. 10 volatile organic compounds from cellulose, hemicellulose, and lignin pyrolysis were identified as potentially harmful due to the following properties: carcinogenicity, toxicity, flammability, skin corrosion/irritation, eye irritation, and mutagenicity, with different degrees of harmfulness. Additionally, the VOCs identified on biochar samples show a potential hazard. Among 140 identified compounds, 33 of them had harmful properties. Therefore, the redeposition on biochar of ketones, aldehydes, cyclic and aromatic hydrocarbons including polyaromatic hydrocarbons, and their derivatives, esters, and furans may lead to environmental contamination due to their release from biochar. A new niche for systematic research on the development of new knowledge regarding the biochars produced from biomass as a source of pollutant emission has been identified.
The optimal threshold of PD-L1 combined positive score to predict the benefit of PD-1 antibody plus chemotherapy for patients with HER2-negative gastric adenocarcinoma: a meta-analysis
Authors: Li Ji-Bin , Lai Ming-Yu , Lin Zhuo-Chen , Guan Wen-Long , Sun Yu-Ting , Yang Jing , Wang Wen-Xuan , Yang Zhi-Rong , Qiu Miao-Zhen 
Published: May 2024

Abstract
Background
Immune checkpoint inhibitors (ICIs) combined with chemotherapy have become the first-line treatment of metastatic gastric and gastroesophageal adenocarcinomas (GEACs). This study aims to figure out the optimal combined positive score (CPS) cutoff value.

Methods
We searched for randomized phase III trials to investigate the efficacy of ICIs plus chemotherapy for metastatic GEACs compared with chemotherapy alone. Pooled analyses of hazard ratios (HRs) based on PD-L1 expression were performed.

Results
A total of six trials (KEYNOTE-062, KEYNOTE-590, KEYNOTE-859, ATTRACTION-04, CheckMate 649, and ORIENT-16) were included, comprising 5,242 patients. ICIs plus chemotherapy significantly improved OS (HR: 0.79, 95% CI 0.72–0.86 in global patients; HR: 0.75, 95% CI 0.57–0.98 in Asian patients) and PFS (HR: 0.74, 95% CI 0.68–0.82 in global patients; HR: 0.64, 95% CI 0.56–0.73 in Asian patients) compared with chemotherapy alone. The differences in OS (ratio of HR: 1.05, 95% CI 0.79–1.40; predictive value: − 5.1%) and PFS (ratio of HR: 1.16, 95% CI 0.98–1.36; predictive value: − 13.5%) were not statistically significant between the global and Asian patients. Subgroup analyses indicated that the optimal CPS threshold was at ≥ 5 for OS and ≥ 10 for PFS with the highest predictive values.

Conclusions
The benefit derived from ICIs plus chemotherapy is similar between Asian and global GEAC patients. However, those with a PD-L1 CPS < 5 or CPS < 10 may not have significant benefits from ICIs therapy. Therefore, it is advisable to routinely assess PD-L1 expression in GEAC patients considered for ICIs treatment.
Low β-carotene bioaccessibility and bioavailability from high fat, dairy-based meal
Authors: Kruger Johanita , Sus Nadine , Moser Andrea , Scholz Sophie , Adler Guenther , Venturelli Sascha , Frank Jan 
Published: May 2024

Abstract
Purpose
The original aim of the study was to determine, in a double-blind 3-arm crossover human trial (n = 7), the effect of supplemental levels of iron (25 mg) and zinc (30 mg) on β-carotene (synthetic) bioavailability (10 h postprandial). However, despite the high dose of supplemental β-carotene (15 mg) consumed with the high fat (18 g), dairy-based breakfast test meal, there was a negligible postprandial response in plasma and triglyceride rich fraction β-carotene concentrations. We then systematically investigated the possible reasons for this low bioavailability of β-carotene.

Methods
We determined (1) if the supplemental β-carotene could be micellised and absorbed by epithelial cells, using a Caco-2 cell model, (2) if the fat from the test meal was sufficiently bioavailable to facilitate β-carotene bioavailability, (3) the extent to which the β-carotene could have been metabolised and converted to retinoic acid/retinol and (4) the effect of the test meal matrix on the β-carotene bioaccessibility (in vitro digestion) and Caco-2 cellular uptake.

Results
We found that (1) The supplemental β-carotene could be micellised and absorbed by epithelial cells, (2) the postprandial plasma triacylglycerol response was substantial (approximately 75–100 mg dL−1 over 10 h), indicating sufficient lipid bioavailability to ensure β-carotene absorption, (3) the high fat content of the meal (approximately 18 g) could have resulted in increased β-carotene metabolism, (4) β-carotene bioaccessibility from the dairy-based test meal was sixfold lower (p < 0.05) than when digested with olive oil.

Conclusion
The low β-carotene bioavailability is probably due to a combination of the metabolism of β-carotene to retinol by BCMO1 and interactions of β-carotene with the food matrix, decreasing the bioaccessibility.

Trail registration
The human trail was retrospectively registered (ClinicalTrail.gov ID: NCT05840848).
Emergency critical care: closing the gap between onset of critical illness and intensive care unit admission
Authors: Dünser Martin W. , Noitz Matthias , Tschoellitsch Thomas , Bruckner Markus , Brunner Markus , Eichler Bernhard , Erblich Romana , Kalb Stephan , Knöll Marius , Szasz Johannes , Behringer Wilhelm , Meier Jens 
Published: May 2024

SummaryCritical illness is an exquisitely time-sensitive condition and follows a disease continuum, which always starts before admission to the intensive care unit (ICU), in the majority of cases even before hospital admission. Reflecting the common practice in many healthcare systems that critical care is mainly provided in the confined areas of an ICU, any delay in ICU admission of critically ill patients is associated with increased morbidity and mortality. However, if appropriate critical care interventions are provided before ICU admission, this association is not observed. Emergency critical care refers to critical care provided outside of the ICU. It encompasses the delivery of critical care interventions to and monitoring of patients at the place and time closest to the onset of critical illness as well as during transfer to the ICU. Thus, emergency critical care covers the most time-sensitive phase of critical illness and constitutes one missing link in the chain of survival of the critically ill patient. Emergency critical care is delivered whenever and wherever critical illness occurs such as in the pre-hospital setting, before and during inter-hospital transfers of critically ill patients, in the emergency department, in the operating theatres, and on hospital wards. By closing the management gap between onset of critical illness and ICU admission, emergency critical care improves patient safety and can avoid early deaths, reverse mild-to-moderate critical illness, avoid ICU admission, attenuate the severity of organ dysfunction, shorten ICU length of stay, and reduce short- and long-term mortality of critically ill patients. Future research is needed to identify effective models to implement emergency critical care systems in different healthcare systems.
k–Generalized Lucas numbers, perfect powers and the problem of Pillai
Authors: Faye Bernadette , García Jonathan , Gomez Carlos A. 
Published: May 2024

AbstractFor an integer$$k\ge 2$$k≥2, let$$L^{(k)}$$L(k)be thek–generalized Lucas sequence which starts with$$0, \ldots , 2,1$$0,…,2,1(a total ofkterms) and for which each term afterwards is the sum of thekpreceding terms. In this paper we assume that an integerccan be represented in at least two ways as the difference between ak–generalized Lucas number and a power ofb, then using the theory of nonzero linear forms in logarithms of algebraic numbers, we bound all possible solutions on this representation ofcin terms ofb. Finally, combination our general result and some known reduction procedures based on the continued fraction algorithm, we find all the integerscand their representations for$$ b\in [2,10]$$b∈[2,10], this argument can be generalized to any$$ b> 10 $$b>10.
Modelling the potential of land use change to mitigate the impacts of climate change on future drought in the Western Cape, South Africa
Authors: Naik Myra , Abiodun Babatunde J. 
Published: May 2024

AbstractSeveral studies have shown that climate change may enhance the severity of droughts over the Western Cape (South Africa) in the future, but there is a dearth of information on how to reduce the impacts of climate change on water yields. This study investigates the extent to which land-use changes can reduce the projected impacts of climate change on hydrological droughts in the Western Cape catchments. For the study, the Soil Water Assessment Tool (SWAT +) model was calibrated and evaluated over several river catchments, and the climate simulation dataset from the COordinated Regional Downscaling EXperiment (CORDEX) was bias-corrected. Using the bias-corrected climate data as a forcing, the SWAT + was used to project the impacts of future climate change on water yield in the catchments and to quantify the sensitivity of the projection to four feasible land-use change scenarios in the catchments. The land-use scenarios are the spread of forest (FOMI), the restoration of shrubland (SHRB), the expansion of cropland (CRDY), and the restoration of grassland (GRSL).The model evaluation shows a good agreement between the simulated and observed monthly streamflows at four stations, and the bias correction of the CORDEX dataset improved the hydrological simulations. The climate change projection features an increase in temperature and potential evaporation, but a decrease in precipitation and all the hydrological variables. The drying occurs across the Western Cape, with the magnitude increasing with higher global warming levels (GWLs). The land-use changes alter these climate change impacts through changes in the hydrological water balance. FOMI increases streamflow and decreases runoff, while SHRB decreases streamflow and runoff. The influence of CRDY and GRSL are more complex. However, all the impacts of land-use changes are negligible compared to the impacts of climate change. Hence, land-use changes in the Western Cape may not be the most efficient strategies for mitigating the impacts of climate change on hydrological droughts over the region. The results of the study have application towards improving water security in the Western Cape river catchments.
Soil C:N:P stoichiometric signatures of grasslands differ between tropical and warm temperate climatic zones
Authors: Hernández-Romero Ángel Héctor , Perroni Yareni , Sánchez Velásquez Lázaro Rafael , Martínez-Hernández Sergio , Ávila-Bello Carlos Héctor , Xu Xiaofeng , Zhang Lihua 
Published: May 2024

AbstractClimate and land management affect nutrient cycling in grassland ecosystems. We aimed to understand whether temperate and tropical grasslands differ in terms of soil organic carbon (SOC), nitrogen (N), and phosphorus (P) concentrations, and their C:N:P stoichiometric ratios in grazed and ungrazed natural grasslands and pastures. For this, we used a meta-analysis approach (1296 records, 241 papers), and regression models to explain the observed patterns in terms of mean annual precipitation (MAP), mean annual temperature (MAT), altitude, and latitude. SOC, N, and P concentrations were higher in temperate regions than in tropical ones, and they negatively correlated with MAT and MAP. The grassland type effect was more significant for tropical regions. In tropical regions, soil C:N ratios were higher in ungrazed than in grazed pastures, and soil N:P ratios in ungrazed sites were higher in pastures than in natural grasslands. Grazing increases soil N and SOC for natural grasslands in temperate regions. Our findings suggest that soil stoichiometric C:N:P stoichiometric signatures in grasslands differed between tropical and temperate regions on a global scale. P is a key element in regulation and restriction on soil C and N cycling in tropical regions but less in the temperate ones. Our findings suggest the direction of effects of grazing or grassland type on C:N:P stoichiometric signature. Since imbalances in soil stoichiometric ratios may have implications for ecosystem functioning, the assessment of these patterns could serve as a valuable tool for management and conservation of grasslands and pastures in both tropical and temperate regions.
An Equity-Focused Assessment of Evidence-Based Parenting Intervention Research
Authors: Kerns Suzanne E. U. , Maddox Samuel J. , Berhanu Ruth E. , Allan Heather , Wilson Rachel A. , Chiesa Antonia , Orsi-Hunt Rebecca , McCarthy Lauren Pryce , Henry Lesly J. , Smith Chaundrissa Oyeshiku 
Published: May 2024

AbstractEvidence-based parenting interventions (EBPI) support children and families to promote resilience, address emotional and behavioral concerns, and prevent or address issues related to child maltreatment. Critiques of EBPIs include concerns about their relevance and effectiveness for diverse populations when they are implemented at population scale. Research methods that center racial equity and include community-based participatory approaches have the potential to address some of these concerns. The purpose of the present review was to document the extent to which methods associated with promoting racial equity in research have been used in studies that contribute to the evidence base for programs that meet evidentiary standards for a clearinghouse that was developed to support the Family First Prevention Services Act in the United States. We developed a coding system largely based on the Culturally Responsive Evaluation model. A sample of 47 papers that are part of the evidence base for ten in-home parent skill-based programs were reviewed and coded. Only three of 28 possible codes were observed to occur in over half of the studies (including race/ethnicity demographic characteristics, conducting measure reliability for the study sample, and including information on socioeconomic status). Although the overall presence of equity-informed methods was low, a positive trend was observed over time. This review highlights ways in which rigorous research can incorporate racial equity into the planning, design, execution, and interpretation and dissemination of programs of study. We posit that doing so improves the external validity of studies while maintaining high-quality research that can contribute to an evidence base.
A heatmap for expected cumulative live birth rate in preimplantation genetic testing for monogenic disorders and chromosomal structural rearrangements
Authors: Van Der Kelen Annelore , Keymolen Kathelijn , Cools Wilfried , De Vos Anick , Pölsler Laura , De Vos Michel , Blockeel Christophe , Fernandez-Gallardo Elia , De Rycke Martine , Berckmoes Veerle , Verdyck Pieter , Hes Frederik Jan , Verpoest Willem 
Published: May 2024

Abstract
Purpose
Our objective is to predict the cumulative live birth rate (CLBR) and identify the specific subset within the population undergoing preimplantation genetic testing for monogenic disorders (PGT-M) and chromosomal structural rearrangements (PGT-SR) which is likely to exhibit a diminished expected CLBR based on various patient demographics.

Methods
We performed a single-centre retrospective cohort study including 1522 women undergoing 3130 PGT cycles at a referral centre for PGT. A logistic regression analysis was performed to predict the CLBR per ovarian stimulation in women undergoing PGT-M by polymerase chain reaction (PCR) or single-nucleotide polymorphism (SNP) array, and in women undergoing PGT-SR by SNP array, array comparative genomic hybridization (CGH) or next-generation sequencing (NGS).

Results
The mean age of women was 32.6 years, with a mean AMH of 2.75 µg/L. Female age and AMH significantly affected the expected CLBR irrespective of the inheritance mode or PGT technology. An expected CLBR < 10% was reached above the age of 42 years and AMH ≤ 1.25 µg/L. We found no significant difference in outcome per ovarian stimulation between the different PGT technologies, i.e. PCR, SNP array, array CGH and NGS. Whereas per embryo transfer, we noticed a significantly higher probability of live birth when SNP array, array CGH and NGS were used as compared to PCR.

Conclusion
In a PGT-setting, couples with an unfavourable female age and AMH should be informed of the prognosis to allow other reproductive choices. The heatmap produced in this study can be used as a visual tool for PGT couples.
Lewis acid catalysis of polydopamine electropolymerisation as a tool for shaping its morphology and electrochemical properties
Authors: Polaczek Krzysztof , Olejnik Adrian , Gumieniak Justyna , Kramek Agnieszka , Karczewski Jakub , Siuzdak Katarzyna 
Published: May 2024

AbstractOrganic–inorganic semiconductor interfaces are of utmost importance in many photoelectrochemical applications, including water splitting and photodegradation of pollutants. The current work focuses on the fabrication and characterisation of transition metal-loaded polydopamine (PDA) electropolymerised on the surface of titania nanotubes. The structural studies via X-ray photoelectron spectroscopy and electron microscopy confirmed the catalytic effect of d-metal salts on the formation of the PDA layer during electropolymerisation. Cu and Ni loading leads to a significant enhancement of the visible absorption compared to that of the pristine PDA, also confirmed by the density functional theory calculations. Although the boost is greater for the thickest coatings, an excess amount of polymer suppresses the charge transfer and thus photocurrent generation. Synthesis in acidic conditions—optimal for photosensitisation—provides structures with a strong increase in the photocurrent quantum efficiency in the visible range, equal to 20% at 400 nm.
Graphical Abstract
An innovative method to strengthen evidence for potential drug safety signals using Electronic Health Records
Authors: Abedian Kalkhoran H. , Zwaveling J. , van Hunsel F. , Kant A. 
Published: May 2024

Abstract
Reports from spontaneous reporting systems (SRS) are hypothesis generating. Additional evidence such as more reports is required to determine whether the generated drug-event associations are in fact safety signals. However, underreporting of adverse drug reactions (ADRs) delays signal detection. Through the use of natural language processing, different sources of real-world data can be used to proactively collect additional evidence for potential safety signals. This study aims to explore the feasibility of using Electronic Health Records (EHRs) to identify additional cases based on initial indications from spontaneous ADR reports, with the goal of strengthening the evidence base for potential safety signals. For two confirmed and two potential signals generated by the SRS of the Netherlands Pharmacovigilance Centre Lareb, targeted searches in the EHR of the Leiden University Medical Centre were performed using a text-mining based tool, CTcue. The search for additional cases was done by constructing and running queries in the structured and free-text fields of the EHRs. We identified at least five additional cases for the confirmed signals and one additional case for each potential safety signal. The majority of the identified cases for the confirmed signals were documented in the EHRs before signal detection by the Dutch Medicines Evaluation Board. The identified cases for the potential signals were reported to Lareb as further evidence for signal detection. Our findings highlight the feasibility of performing targeted searches in the EHR based on an underlying hypothesis to provide further evidence for signal generation.