bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anisodamine for the prevention of contrast-induced nephropathy in patients with acute coronary syndrome: a pilot systematic review and meta-analysis of randomized controlled trials
Authors: Jain Hritvik , Odat Ramez M. , Jain Jyoti , Dey Debankur , Hussein Ayham Mohammad , Marsool Mohammed Dheyaa Marsool , Shahbaz Haania , Mathur Aniket , Yadav Himani , Passey Siddhant , Yadav Rukesh 
Published: May 2024

Introduction:
Contrast-induced nephropathy (CIN) is a common post-procedural complication of percutaneous coronary intervention for acute myocardial infarction (AMI). Anisodamine hydrobromide is an alkaloid that has demonstrated efficacy in improving microcirculation. This meta-analysis aims to evaluate the reno-protective effects of Anisodamine in patients undergoing percutaneous coronary intervention (PCI) for AMI.

Methods:
PubMed, Embase, Cochrane Library, Scopus, and clinicaltrials.gov were searched from inception to January 2024 for randomized controlled trials (RCTs) comparing the efficacy of Anisodamine in preventing the development of CIN. Outcomes of interest included the incidence of CIN, serum creatinine levels, and estimated glomerular filtration rate (eGFR). A random-effects model was used for pooling standard mean differences (SMDs) and odds ratios (ORs) with a 95% CI. Statistical significance was considered at a P less than 0.05.

Results:
Three RCTs involving 563 patients were included. Anisodamine was associated with a reduction in the incidence of CIN [OR: 0.44; 95% CI: 0.28, 0.69; P=0.0003], a reduction in serum creatinine levels at 48 [SMD: −6.78; 95% CI: −10.54,−3.02; P=0.0004] and 72 h [SMD: −6.74; 95% CI: −13.33,−0.15; P=0.03], and a higher eGFR at 24 [SMD: 5.77; 95% CI: 0.39, 11.14; P=0.03], and 48 h [SMD: 4.70; 95% CI: 2.03,7.38; P=0.0006]. The levels of serum creatinine at 24 h and eGFR value at 72 h were comparable between both groups.

Conclusions:
Anisodamine has demonstrated clinical efficacy in ameliorating the development of CIN post-PCI in AMI patients. Large, multi-centric RCTs are warranted to evaluate the robustness of these findings.
Perceptions of Responsibilities by Primary Care Staff in a Patient-Centered Medical Home
Authors: Wakefield Bonnie J. , Farag Amany , Paez Monica B. , Stewart Greg L. 
Published: May 2024

OBJECTIVE
To examine the extent to which Veterans Health Administration (VHA) Patient-Aligned Care Team (PACT) members have a shared understanding/ agreement upon and enact responsibilities within the team.

BACKGROUND
The PACT model focuses on team-based care management. However, lack of a shared understanding of team-based care management roles and responsibilities makes system-wide implementation a challenge.

METHODS
Quantitative and qualitative analysis of national survey data collected in 2022 from primary care personnel working in a VHA-affiliated primary care facility.

RESULTS
Significant discrepancies exist in responses about what core team members say they do and what others perceive they should be doing, indicating either a lack of agreement, knowledge, or training about what core team members should do.

CONCLUSIONS
Successful implementation of a team-based model requires adequate support and training for teamwork including shared mental models to work according to their clinical competency. Clear guidance and communication of expectations are critical for role clarity.
Thriving Through Calamity
Authors: Newcomb Patricia , Wells Jo Nell , Urban Regina 
Published: May 2024

OBJECTIVE
The study purpose was to generate theory to explain why some hospital staff chose to stay on the job during a prolonged public health crisis.

BACKGROUND
The “great resignation” of 2021 created shortages across the healthcare industry. Why some healthcare staff chose to stay at work when coworkers were leaving in large numbers through retirement, transition to different careers, or perceived suddenly better clinical opportunities was not clear.

METHODS
Qualitative Grounded Theory methods guided this research study. Sixteen healthcare workers participated in open-ended interviews that provided data to identify major concepts in an emerging model of commitment during crisis.

RESULTS
A “Commit to Stay” model emerged showing 4 major influences including sense of personal agency, supportive organization, social connections at work, and external connections and influence.

CONCLUSIONS
The Commit to Stay conceptual model can help guide nurse leaders as they grapple with supporting those who choose to stay at work in healthcare during intense, sustained healthcare crises.
Extraskeletal Ewing Sarcoma of the Gastrointestinal and Hepatobiliary Tract
Authors: Shiyanbola Oyewale , Nigdelioglu Recep , Dhall Deepti , González Iván A. , Warmke Laura M. , Schechter Shula , Choi Won-Tak , Hu Shaomin , Voltaggio Lysandra , Zhang Yujie , Liang Tom Z. , Ko Huaibin M. , Charville Greg W. , Longacre Teri A. 
Published: May 2024

Ewing sarcoma (ES) is an uncommon mesenchymal neoplasm that typically develops as a bone mass, although up to 30% arise in extraskeletal sites. ES of the gastrointestinal (GI) and hepatobiliary tract is rare and may be misdiagnosed as other, more common neoplasms that occur in these sites. However, the correct classification of extraskeletal ES is important for timely clinical management and prognostication. We reviewed our experience of ES in the GI and hepatobiliary tract in order to further highlight the clinicopathologic features of these neoplasms and document the potential for misdiagnosis in this setting. The archives and consultation files of 6 academic institutions were retrospectively queried for cases of ES occurring in the GI and hepatobiliary tract. The histologic slides and ancillary studies were reviewed and clinical data were retrieved for each case through the electronic medical records, when available. Twenty-three patients with ES in the GI and/or hepatobiliary tract were identified from 2000 to 2022. Of these, 11 were women and 12 were men with a median age of 38 years (range, 2 to 64). Tumor locations included the pancreas (n=5), liver (n=2), stomach (n=3), colorectum (n=3), and small intestine (n=5), as well as tumors involving multiple organs, pelvis and retroperitoneum (n=5). Tumor size varied between 2 cm and 18 cm. Twenty were primary and 3 were metastases. Of the 23 cases, only 17% were initially diagnosed as ES. The most common misdiagnoses involved various forms of neuroendocrine neoplasia due to expression of synaptophysin and other neuroendocrine markers (22%). A wide variety of diagnoses including GI stromal tumor was considered due to aberrant CD117 expression (4%). The diagnosis of ES was ultimately confirmed by detection of the EWSR1 rearrangement in 22 cases. The remaining case was diagnosed using traditional immunohistochemistry. Follow-up information was available in 20 cases, with follow-up time varying between 2 and 256 months. Six patients with follow-up died of disease between 6 and 60 months following initial presentation. Our data indicate ES in the GI and hepatobiliary tract is commonly misdiagnosed leading to a delay in therapy. In light of the attendant therapeutic and prognostic implications, ES should be considered in the differential diagnosis of any GI or hepatobiliary tumor with epithelioid and/or small round cell morphology.
Pseudosquamous Adenocarcinoma of the Lung
Authors: Suster David I. , Ronen Natali , Suster Saul 
Published: May 2024

Pseudosquamous adenocarcinoma of the lung is an unusual morphologic variant of poorly differentiated non–small cell lung carcinoma that superficially resembles a squamous cell carcinoma. We have examined 10 cases of these tumors in 4 women and 6 men, aged 47 to 93 years. The tumors were all peripheral and measured from 1.5 to 5.5 cm. All cases were characterized by solid nests of large polygonal tumor cells containing atypical nuclei with abundant cytoplasm and sharp cell borders, adopting a pavement-like architecture that simulated squamous cell carcinoma. Some cases demonstrated intracytoplasmic hyaline inclusions suggestive of keratinization. The nests of tumor cells often showed central comedo-like areas of necrosis. Intercellular bridges were not seen in any of the cases. The tumors often displayed marked clearing of the cytoplasm enhancing their epidermoid appearance. In 4 cases, the solid pseudosquamous areas were seen to merge with a focal lepidic adenocarcinoma component, and in 1 case, abortive microscopic foci of acinar differentiation were also noted within the tumor. One case showed focal sarcomatoid spindle cell areas. The tumor cells were negative for p40 and CK5/6 and labeled with TTF1 or Napsin-A, confirming an adenocarcinoma phenotype. Clinical follow-up information was available in 8 patients; 6 patients died of their tumors between 6 months to 11 years after diagnosis (mean: 3.1 y). One patient died of complications related to surgery and one patient with a low-stage tumor died at 27 years from other causes. Solid pattern adenocarcinomas can be confused for squamous cell carcinoma and may require immunohistochemistry to determine their true phenotype.
Elevated 68Ga-FAPI Activity in Pulmonary Inflammatory Pseudotumor
Authors: Xie Yang , Tang Wenxin , Ma Jiao , Wang Yudi , Chen Yue 
Published: May 2024

Abstract
We present a case of pulmonary inflammatory pseudotumor with elevated 68Ga-FAPI activity. Our case suggested that pulmonary inflammatory pseudotumor should be considered in the differential diagnosis of cancer-like solitary pulmonary nodules with increased 68Ga-FAPI uptake.
Endoscopic Versus Open Carpal Tunnel Release
Authors: El Masri Jad , Chanbour Hani , Ghazi Maya , El Masri Diala , Salameh Pascale , liles Campbell , Hill J. Bradford , Zuckerman Scott L. 
Published: May 2024

Introduction
Whether endoscopic carpal tunnel release (ECTR) versus open carpal tunnel release (OCTR) has superior outcomes remains a controversial topic. Therefore, we sought to perform an umbrella review and meta-analysis to compare ECTR and OCTR with regards to (1) postoperative functional ability, (2) operative outcomes, and (3) time to return to work.

Methods
A PubMed, Scopus, and Cochrane database search was conducted for all meta-analyses comparing ECTR and OCTR performed between 2000 and 2022 in accordance to PRISMA and Joanna Briggs Institute guidance for umbrella reviews. The primary outcomes were as follows: (1) functional ability—symptoms severity, postoperative grip strength, postoperative pinch strength, 2-point discrimination, and pain; (2) operative outcomes—operation time, total complications, nerve injury, and scar-related complication; and (3) time to return to work. Quality was assessed using the Assessment of Multiple Systematic Reviews. Pooled analysis was performed to compare several clinical outcome measures between groups, depending on the availability of data using Review Manager Version 5.2.11.

Results
A total of 9 meta-analyses were included, 5 were of high quality and 4 were moderate quality. For functional ability, ECTR was associated with better pinch strength after 3 months (0.70, 95% confidence interval [CI] = 0.00, 1.40, P = 0.05) and 6 months (0.77, 95% CI = 0.14, 1.40, P = 0.02, I
2 = 84%). For return to work, OCTR was associated with longer return to work compared with ECTR (−10.89, 95% CI = −15.14, −6.64, P < 0.00001, I
2
= 83%). There were no significant differences between OCTR and ECTR in the hand function, symptom severity, grip strength, pain, operation time, and total complications.

Conclusions
In an umbrella review and meta-analysis of ECTR versus OCTR, ECTR was associated with a higher pinch strength, and a shorter time to return to work. Differences in major complications, such as nerve injury, were unclear due to statistical inconsistency and bias.
Lefort 1 Osteotomy Study of Maxillary Bone in Caprine Skull Model: Comparison of Different Osteotomy Techniques (Piezo Versus Lindemann Bur Versus Manual Chisel)
Authors: Serin Merdan , Altinel Dinçer , Toplu Gaye , Rakici Ibrahim Taşkın , Toplu Selçuk Göksel 
Published: May 2024

Objective:
In this study, we aimed to compare the efficiency of different osteotomy techniques for Lefort 1 osteotomy in an experimental caprine skull model.

Methods:
Twelve caprine skulls were used for the study. Skulls were divided into 3 groups: (1) manual chisel group, (2) Lindemann bur group, and (3) piezo osteotomy group. Bilateral osteotomies were performed on each skull. Results were evaluated with three-dimensional computerized tomography scans and macroscopic observations of the mucosal tears and soft tissue.

Results:
The mean length of the bone gap in the manual, Lindemann, and piezo groups was 4.8 (±0.7), 3.38 (±1.49), and 1.39 (±0.3) mm, respectively (P < 0.05). The mean number of comminuted fractures in the manual, Lindemann, and piezo groups was 5.5 (±1.4), 1.6 (±0.3), and 0.6 (±0.5), respectively (P < 0.05). Mucosal tearing and soft tissue damage based on subjective inspection observations were negligible in the piezo technique. Soft tissue and mucosal damage were observed significantly more in the manual chisel osteotomy method compared with the other 2 techniques.

Conclusion:
We anticipate that piezo, which has started to be used in new application areas besides rhinoplasty, will continue to be used more widely, especially in reconstructive orthognathic surgery, due to the minimal damage it causes to tissues. With the long-term results, much healthier interpretations can be made.
Platelet releasates mitigate the endotheliopathy of trauma
Authors: Gallagher Lauren T. , LaCroix Ian , Fields Alexander T. , Mitra Sanchayita , Argabright Amy , D’Alessandro Angelo , Erickson Christopher , Nunez-Garcia Brenda , Herrera-Rodriguez Kimberly , Chou Yu (Celine) , Stocker Benjamin W. , Ramser Benjamin J. , Thielen Otto , Hallas William , Silliman Christopher C. , Kornblith Lucy Z. , Cohen Mitchell J. 
Published: May 2024

BACKGROUNDPlatelets are well known for their roles in hemostasis, but they also play a key role in thromboinflammatory pathways by regulating endothelial health, stimulating angiogenesis, and mediating host defense through both contact dependent and independent signaling. When activated, platelets degranulate releasing multiple active substances. We hypothesized that the soluble environment formed by trauma platelet releasates (TPR) attenuates thromboinflammation via mitigation of trauma induced endothelial permeability and metabolomic reprogramming.METHODSBlood was collected from injured and healthy patients to generate platelet releasates and plasma in parallel. Permeability of endothelial cells when exposed to TPR and plasma (TP) was assessed via resistance measurement by electric cell-substrate impedance sensing (ECIS). Endothelial cells treated with TPR and TP were subjected to mass spectrometry-based metabolomics.RESULTSTP increased endothelial permeability, whereas TPR decreased endothelial permeability when compared with untreated cells. When TP and TPR were mixed ex vivo, TPR mitigated TP-induced permeability, with significant increase in AUC compared with TP alone. Metabolomics of TPR and TP demonstrated disrupted redox reactions and anti-inflammatory mechanisms.CONCLUSIONTrauma platelet releasates provide endothelial barrier protection against TP-induced endothelial permeability. Our findings highlight a potential beneficial action of activated platelets on the endothelium in injured patients through disrupted redox reactions and increased antioxidants. Our findings support that soluble signaling from platelet degranulation may mitigate the endotheliopathy of trauma. The clinical implications of this are that activated platelets may prove a promising therapeutic target in the complex integration of thrombosis, endotheliopathy, and inflammation in trauma.
Daily quetiapine after severe TBI improves learning and memory
Authors: Bele Priyanka , Thaploo Advait , Coons Michael , Culkin Matthew C. , Santos Patricia , Martinez-Quinones Patricia , Georges Anastasia P. , Anderson Erin , Browne Kevin D. , Jacovides Christina , Kaplan Lewis J. , Meaney David F. , Smith Douglas H. , Pascual Jose L. 
Published: May 2024

BACKGROUNDTraumatic brain injury (TBI) induces cognitive deficits driven by neuroinflammation and cerebral edema. The commonly used atypical antipsychotic, quetiapine (QTP), has been recently shown to improve post-TBI outcomes. We hypothesized that QTP would thereby improve animal learning and memory 2 weeks after severe TBI.METHODSCD1 male mice (n = 35) underwent severe TBI (controlled cortical impact, injury, I) or sham craniotomy (S), followed by BID saline (P, placebo) or QTP (10 or 20 mg/kg, IP) for 2 weeks. Animals underwent Morris Water Maze (MWM) exercises to gauge spatial learning and memory. The distance and time required for swimming animals to reach the platform area (Zone 5, Z5) located in quadrant 1 (Zone 1, Z1) was calculated from digital video recordings analyzed using Ethovision software. Animal bodyweights were recorded daily and on Day 14, injured cerebral hemispheres were procured for edema determination (wet-to-dry ratio). Intergroup differences were evaluated with ANOVA/Bonferroni correction (p< 0.05).RESULTSOn Day 14, animal weight loss recovery was lowest in I + P compared to I + QTP20 and I + QTP10 (p≤ 0.01 for either). Cerebral edema was greatest in I + P, and only significantly decreased in I + QTP20 (p< 0.05). Both QTP doses similarly improved spatial learning by significantly reducing latency time and travel distance to target zones (p< 0.05). In probe memory trials, only I + QTP20 and not I + QTP10 significantly favored animal reaching or crossing into target zones (p< 0.05).CONCLUSIONPost-TBI QTP reduces brain edema and improves spatial learning and memory with a potential dose dependence impact benefiting memory up to 14 days. These data suggest an unanticipated QTP benefit following brain injury that should be specifically explored.
The power of sound: unravelling how acoustic communication shapes group dynamics
Authors: Briefer Elodie F. , Xie Bing , Engesser Sabrina , Sueur Cedric , Freeberg Todd M. , Brask Josefine Bohr 
Published: May 2024

Acoustic signalling is a key mode of communication owing to its instantaneousness and rapid turnover, its saliency and flexibility and its ability to function strategically in both short- and long-range contexts. Acoustic communication is closely intertwined with both collective behaviour and social network structure, as it can facilitate the coordination of collective decisions and behaviour, and play an important role in establishing, maintaining and modifying social relationships. These research topics have each been studied separately and represent three well-established research areas. Yet, despite the close connection of acoustic communication with collective behaviour and social networks in natural systems, only few studies have focused on their interaction. The aim of this theme issue is therefore to build a foundation for understanding how acoustic communication is linked to collective behaviour, on the one hand, and social network structure on the other, in non-human animals. Through the building of such a foundation, our hope is that new questions in new avenues of research will arise. Understanding the links between acoustic communication and social behaviour seems crucial for gaining a comprehensive understanding of sociality and social evolution.
This article is part of the theme issue ‘The power of sound: unravelling how acoustic communication shapes group dynamics’.
The relative contribution of acoustic signals versus movement cues in group coordination and collective decision-making
Authors: Liao Chun-Chieh , Magrath Robert D. , Manser Marta B. , Farine Damien R. 
Published: May 2024

To benefit from group living, individuals need to maintain cohesion and coordinate their activities. Effective communication thus becomes critical, facilitating rapid coordination of behaviours and reducing consensus costs when group members have differing needs and information. In many bird and mammal species, collective decisions rely on acoustic signals in some contexts but on movement cues in others. Yet, to date, there is no clear conceptual framework that predicts when decisions should evolve to be based on acoustic signals versus movement cues. Here, we first review how acoustic signals and movement cues are used for coordinating activities. We then outline how information masking, discrimination ability (Weber’s Law) and encoding limitations, as well as trade-offs between these, can identify which types of collective behaviours likely rely on acoustic signals or movement cues. Specifically, our framework proposes that behaviours involving the timing of events or expression of specific actions should rely more on acoustic signals, whereas decisions involving complex choices with multiple options (e.g. direction and destination) should generally use movement cues because sounds are more vulnerable to information masking and Weber’s Law effects. We then discuss potential future avenues of enquiry, including multimodal communication and collective decision-making by mixed-species animal groups.
This article is part of the theme issue ‘The power of sound: unravelling how acoustic communication shapes group dynamic’.
Sex-specific single cell-level transcriptomic signatures of Rett syndrome disease progression
Authors: Sharifi Osman , Haghani Viktoria , Neier Kari E. , Fraga Keith J. , Korf Ian , Hakam Sophia M. , Quon Gerald , Johansen Nelson , Yasui Dag H. , LaSalle Janine M. 
Published: May 2024

AbstractDominant X-linked diseases are uncommon due to female X chromosome inactivation (XCI). While random XCI usually protects females against X-linked mutations, Rett syndrome (RTT) is a female neurodevelopmental disorder caused by heterozygousMECP2mutation. After 6-18 months of typical neurodevelopment, RTT girls undergo poorly understood regression. We performed longitudinal snRNA-seq on cerebral cortex in a construct-relevantMecp2e1mutant mouse model of RTT, revealing transcriptional effects of cell type, mosaicism, and sex on progressive disease phenotypes. Across cell types, we observed sex differences in the number of differentially expressed genes (DEGs) with 6x more DEGs in mutant females than males. Unlike males, female DEGs emerged prior to symptoms, were enriched for homeostatic gene pathways in distinct cell types over time, and correlated with disease phenotypes and human RTT cortical cell transcriptomes. Non-cell-autonomous effects were prominent and dynamic across disease progression ofMecp2e1mutant females, indicating wild-type-expressing cells normalizing transcriptional homeostasis. These results improve understanding of RTT progression and treatment.
COVID-19 transmission dynamics in South Korea prior to vaccine distribution
Authors: Suh Jiyeon , Galanti Marta , Yamana Teresa K. , Perini Matteo , Kaondera-Shava Roselyn , Shaman Jeffrey 
Published: May 2024

AbstractIn early 2020, South Korea experienced a large coronavirus disease 2019 (COVID-19) outbreak. However, despite its proximity to China, where the virus had emerged, and the high population density of the Seoul metropolitan area, a major international hub, South Korea effectively contained the spread of COVID-19 using non-pharmaceutical interventions until vaccine distribution in 2021. Here, we built a metapopulation model with a susceptible-exposed-infectious-quarantined-recovered (SEIQR) structure and combined it with the ensemble adjustment Kalman filter to infer the transmission dynamics of COVID-19 in South Korea from February 2020 until vaccine deployment. Over the study period, the fraction of documented infections (ascertainment rate) was found to increase from 0.50 (95% credible interval (CI): 0.26—0.77) to 0.62 (95% CI: 0.39—0.86). The cumulative number of total infections, including both documented cases and undocumented infections, was less than 1% of the South Korean population at the end of the simulation period, indicating that the majority of people had yet to be infected when vaccine administration began. These findings enhance understanding of the COVID-19 outbreak in South Korea and highlight the importance of preparedness and response in managing global pandemics.