bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning the exchange bias training effect in top‐ and bottom‐pinning FeNi/FeMn bilayers
Authors: Yang M. , Ge J. J. , Xue X. B. , Yang Y. , Rui W. B. , You B. , Sun L. , Du J. , Hu A. 
Published: August 2011

AbstractA magnetic field of 600 Oe, different from the original pinning direction (PD), is applied in the film plane to tune the exchange bias (EB) training effect in both top‐ and bottom‐pinning FeNi/FeMn bilayers. Compared to the top‐pinning structures, the training effects in the bottom‐pinning ones are more easily tuned, characterized by larger rotation of the PD just after the field tuning. The EB tuning effect is thought to be originated from spin frustration near the FM/AF interface, and the interfacial AF spins are less stable and readily to be tuned by external field in the bottom‐pinning bilayers than those in the top‐pinning bilayers. This statement can also be validated by the azimuthal dependence of the EB effect.
Mechanical fabrication of carbon nanotube/TiO2 nanoparticle composite films and their field‐emission properties
Authors: He Kai‐Xuan , Su Juan , Guo Deng‐Zhu , Xing Ying‐Jie , Zhang Geng‐Min 
Published: August 2011

AbstractA simple mechanical rubbing method for fabricating films of carbon nanotubes (CNTs) and CNTs‐based composite materials is presented, and films of CNTs, TiO2 nanoparticles, and CNTs‐TiO2 composite with different proportions are realized. The field emission (FE) properties of these films are systematically studied in comparison experiments. It is found that the TiO2 films show neglectable FE current in the electrical field up to 10 V/µm, and CNTs‐TiO2 composite films with an optimum proportion (7–10 wt.%) of TiO2 nanoparticles exhibit dramatically‐improved FE properties compared with pure CNT films, in lowering turn‐on filed to 1.3 V/µm (CNT films: 2.5 V/µm), suppressing the degradation of FE current, and increasing the FE uniformity and stability. The mechanisms responsible for such improvement are also discussed.
Resonant multimeander‐metasurfaces: A model system for superlenses and communication devices
Authors: Schweizer H. , Fu L. , Hentschel M. , Weiss T. , Bauer C. , Schau P. , Frenner K. , Osten W. , Giessen H. 
Published: August 2011

AbstractWe study the optical properties of single and double meander meta surfaces (MMS). A strong and resonant photon–plasmon coupling in single and double structures is found. The effect can be used to mimic bulk negative index materials with a promise for lower optical losses. Based on the optical properties of the MMS structures the application fields reach from near/far field lenses to communication devices. The strong photon–plasmon coupling effects pave the route for dense optical/plasmonic integration.
Towards description of kinetics of dissolution and cluster growth in C60/NMP solutions
Authors: Tropin T. V. , Avdeev M. V. , Kyzyma O. A. , Yeremin R. A. , Jargalan N. , Korobov M. V. , Aksenov V. L. 
Published: August 2011

AbstractModel growth of fullerene C60 clusters in the solution in N‐methyl‐2‐pyrrolidone (NMP) is considered in the frame of nucleation theory. In addition to the previous models, the reason for the supersaturation caused the cluster formation is related to the appearance of new C60–NMP complexes with NMP. The dissolution process is taken into account. Different regimes of the proposed models depending on the kinetic parameters are distinguished and analyzed.
Photoluminescence evaluation of the quality of Cd0.9Zn0.1Te detectors doped with different indium concentrations
Authors: Naseka Yu. , Strilchuk O. , Komar V. , Terzin I. , Sulima S. , Bryleva K. 
Published: August 2011

AbstractWith the aim to determine an optimal indium (In) concentration in Cd0.9Zn0.1Te:In nuclear radiation detectors for a good material quality, low‐temperature photoluminescence (LTPL) measurements have been performed at 5 K in the energy range of 1.2–1.7 eV. The LTPL spectrum of initial sample contained a neutral acceptor bound exciton (A0X) peak at 1.635 eV, donor–acceptor pair (DAP) peak at 1.606 eV with its 1LO phonon replica, and deep‐level defects (D) peak at 1.455 eV. In doping leads to the appearance of a new relatively intensive peak at 1.652 eV that is caused by a shallow neutral donor bound exciton (D0X) due to In substituting cadmium vacancies (VCd). At In concentrations of about 8 × 1016–1017 cm−3 the value of $I_{{\rm D}^{{\rm 0}} {\rm X}} /I_{{\rm D}} $ ratio is maximal, which indicates a low density of detrimental carrier traps and, therefore, high‐material quality. We believe that at such concentrations the majority of as‐grown Cd vacancies will be substituted by In atoms and, therefore, noted concentrations are optimal, which was confirmed by the correlation with mobility–lifetime product.
Influence of chorionicity on perinatal outcome in a large cohort of Danish twin pregnancies
Authors: Oldenburg A. , Rode L. , Bødker B. , Ersbak V. , Holmskov A. , Jørgensen F. S. , Larsen H. , Larsen T. , Laursen L. , Mogensen H. , Petersen O. B. , Rasmussen S. , Skibsted L. , Sperling L. , Stornes I. , Zingenberg H. , Tabor A. 
Published: August 2011

AbstractObjectiveTo assess outcome in twin pregnancies according to chorionicity.MethodsA cohort was retrieved from local ultrasound databases at 14 obstetric departments in Denmark, comprising all twin pregnancies with two live fetuses scanned between weeks 11 and 14 in the period 1 January 2004 to 31 December 2006. Outcome data were retrieved from the National Board of Health.ResultsAmong 2038 twin pregnancies, 1757 (86.2%) were dichorionic (DC) and 281 (13.8%) were monochorionic diamniotic (MC). In MC pregnancies, the rate of spontaneous fetal loss in both second and third trimesters was more than threefold higher than the comparable rate in DC pregnancies: 6.0% vs. 1.9% for at least one fetus in the second trimester (P < 0.001) and 2.1% vs. 0.7% in the third trimester (P = 0.03). In 98.4% of DC pregnancies and in 91.1% of MC pregnancies, at least one infant was liveborn. Amongst pregnancies with two live fetuses at 24 weeks, the proportion with two live infants at 28 days after delivery was 97.5% and 95.1%, respectively.ConclusionsThe increased incidence of fetal loss in MC pregnancies compared with DC pregnancies predominantly occurs before 24 weeks' gestation. After this stage, although the risk of intrauterine fetal death is still higher in MC than in DC pregnancies, if both fetuses are alive at 24 weeks, the chance of a woman having two live infants 1 month after delivery is similar in MC and DC pregnancies. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Exome sequencing-based copy-number variation and loss of heterozygosity detection: ExomeCNV
Authors: Sathirapongsasuti Jarupon Fah , Lee Hane , Horst Basil A. J. , Brunner Georg , Cochran Alistair J. , Binder Scott , Quackenbush John , Nelson Stanley F. 
Published: August 2011

Abstract
Motivation: The ability to detect copy-number variation (CNV) and loss of heterozygosity (LOH) from exome sequencing data extends the utility of this powerful approach that has mainly been used for point or small insertion/deletion detection.
Results: We present ExomeCNV, a statistical method to detect CNV and LOH using depth-of-coverage and B-allele frequencies, from mapped short sequence reads, and we assess both the method's power and the effects of confounding variables. We apply our method to a cancer exome resequencing dataset. As expected, accuracy and resolution are dependent on depth-of-coverage and capture probe design.
Availability: CRAN package ‘ExomeCNV’.
Contact: fsathira@fas.harvard.edu; snelson@ucla.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Narrowing down the critical region within env gene for determining neuropathogenicity of murine leukemia virus A8
Authors: Seki Yohei , Hirano Naoki , Mizukura Misaho , Watanabe Rihito , Takase‐Yoden Sayaka 
Published: August 2011

ABSTRACTFriend murine leukemia virus clone A8 causes spongiform neurodegeneration in the rat brain, and the env gene of A8 is a primary determinant of neuropathogenicity. In order to narrow down the critical region within the env gene that determines neuropathogenicity, we constructed chimeric viruses having chimeric env between A8 and non‐neuropathogenic 57 on the background of A8 virus. After replacement of the BamHI (at nucleotide 5715)‐AgeI (at nucleotide 6322) fragment of A8 virus with the corresponding fragment of 57, neuropathogenicity was lost. In contrast, the chimeric viruses that have the BamHI (5715)‐AgeI (6322) fragment of A8 induced spongiosis in 100% of infected rats at the same or slightly lower intensity than A8 virus. These results indicate that the BamHI (5715)‐AgeI (6322) fragment of A8, which contains the signal sequence and the N‐terminal half of RBD, is crucial for the induction of spongiform neurodegeneration. In the BamHI (5715)‐AgeI (6322) fragment, seven amino acids differed between A8 and 57, one in the signal sequence and six in RBD, which suggests that these amino acids significantly contribute to the neuropathogenicity of A8.
Mycoplasma pneumoniae induces interleukin‐8 production via the epidermal growth factor receptor pathway
Authors: Arae Ken , Hirata Masako , Kurata Satoshi , Kamiya Shigeru , Taguchi Haruhiko 
Published: August 2011

ABSTRACTIn mycoplasmal pneumonia, the bronchi are histopathologically filled with polymorphonuclear leukocytes. The EGFR pathway is involved in IL‐8 production. We investigated the contribution of the EGFR pathway to IL‐8 production by bronchial epithelial cells (A549) stimulated with Mp‐Ag. The IL‐8 production by A549 cells stimulated with Mp‐Ag was decreased by the addition of an EGFR kinase inhibitor or transfection with small interfering RNA against EGFR. The levels of epiregulin mRNA in A549 cells were increased by stimulation with Mp‐Ag. In conclusion, the EFGR pathway participates in IL‐8 production by bronchial epithelial cells stimulated with Mp‐Ag.
Impact of early weight loss on growth of Caesarean delivered babies: how long does it last?
Authors: Bakar F. T. , Ozen A. , Karatepe H. Ö. , Berber M. , Ercan H. 
Published: August 2011

AbstractBackground  We hypothesized that Caesarean delivered babies might experience excessive weight loss during neonatal period.Aim  To investigate amount of weight loss among Caesarean delivered babies with exclusive breastfeeding and to identify role of relative weight change (RWC) in early postnatal period on the growth of infants in subsequent months.Methods  We studied healthy infants born ≥36 completed weeks, by Caesarean section between September 2008 and August 2009, with Apgar scores >7. Weight measurements were performed at birth, at 24 h postpartum and at days 2, 4, 7, 14, 30 and monthly up to 6 months. Predictive roles of RWC at each assessment on detecting excessive weight loss and poor weight gain in 1st month, as well as bodyweight z scores in subsequent months were assessed.Results  We studied 160 infants (88 female, 72 male) with a mean gestational age of 38.01 ± 1 weeks and birthweight of 3239 ± 421 g. Overall, 22.5% of infants lost >10% of birthweight; 11.9% at day 2, 16.9% at day 4 and 6.6% at day 7. Degree of weight loss was not related with parity, gestational age, birthweight or type of anaesthesia. Predictive values of RWCs in detecting poor weight gain in 0–30 days were: 2nd day; limit =−9.4%, specificity = 91.5%, 4th day; limit =−10.2%, specificity = 89.4%, 7th day; limit =−6.3%, specificity = 85%, sensitivity = 78%, 14th day; limit =+0.8%, specificity = 91.5%, sensitivity = 83.3%. Adjusting for birthweight z scores, RWC at 14th day had a significant influence on 1st and 2nd month bodyweight z scores. Bodyweight z scores were significantly correlated with the z scores of bodyweight in 1–5 months but not with that of 6 months.Conclusion  Incidence of excessive weight loss is very high among Caesarean delivered babies. RWC at earlier measurements proves satisfactory in predicting poor infant growth. Management strategies based on identifying infants at risk could prevent excessive weight loss and improve future growth of those infants.
An engineeredPlasmodium falciparumC-terminal 19-kilodalton merozoite surface protein 1 vaccine candidate induces high levels of interferon-gamma production associated with cellular immune responses to specific peptide sequences in Gambian adults naturally exposed to malaria
Authors: Bisseye C , Yindom L M , Simporé J , Morgan W D , Holder A A , Ismaili J 
Published: August 2011

SummaryThe 19-kDa C-terminal region of merozoite surface protein 1 (MSP119), a major blood stage malaria vaccine candidate, is the target of cellular and humoral immune responses in humans naturally infected with Plasmodium falciparum. We have previously described engineered variants of this protein, designed to be better vaccine candidates, but the human immune response to these proteins has not been characterized fully. Here we have investigated the antigenicity of one such variant compared to wild-type MSP119-derived protein and peptides. Gambian adults produced both high T helper type 1 (Th1) [interferon (IFN)-γ] and Th0/Th2 [interleukin (IL)-13 and sCD30] responses to the wild-type MSP119 and the modified protein as wells as to peptides derived from both forms. Response to the modified MSP119 (with three amino acid substitutions: Glu27Tyr, Leu31Arg and Glu43Leu) relative to the wild-type, included higher IFN-γ production. Interestingly, some peptides evoked different patterns of cytokine responses. Modified peptides induced higher IL-13 production than the wild-type, while the conserved peptides P16 and P19 induced the highest IFN-γ and IL-13 and/or sCD30 release, respectively. We identified P16 as the immunodominant peptide that was recognized by cells from 63% of the study population, and not restricted to any particular human leucocyte antigen D-related (HLA-DR) type. These findings provide new and very useful information for future vaccine development and formulation as well as potential Th1/Th2 immunmodulation using either wild-type or modified protein in combination with their peptides.
Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation – revelation of B cell developmental pathways and lineage phenotypes
Authors: Bemark M , Holmqvist J , Abrahamsson J , Mellgren K 
Published: August 2011

SummaryOTHER ARTICLES PUBLISHED IN THIS MINI-REVIEW SERIES ON B CELL SUBSETS IN DISEASEB cells in multiple sclerosis: drivers of disease pathogenesis and Trojan horse for Epstein—Barr virus entry to the central nervous system? Clinical and Experimental Immunology 2012, 167: 1–6. Transitional B cells in systemic lupus erythematosus and Sjögren's syndrome: clinical implications and effects of B cell-targeted therapies. Clinical and Experimental Immunology 2012, 167: 7–14.Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.
What is a safe distal resection margin in rectal cancer patients treated by low anterior resection without preoperative radiotherapy?
Authors: Bernstein T. E. , Endreseth B. H. , Romundstad P. , Wibe A. ,   on behalf of the Norwegian Colorectal Cancer Registry
Published: August 2011

AbstractAim  The aim of this study was to examine what constitutes an acceptable distal resection margin (DRM) when performing sphincter‐saving surgery for rectal cancer without preoperative radiotherapy.Method  This national study consisted of 3571 patients for whom information on DRM was available and who were radically treated by anterior resection between 1993 and 2004. Of these, 3342 (93.5%) patients had not received preoperative radiotherapy. The DRM was measured on fixed specimens.Results  The 5‐year local recurrence rate was 14.5% for patients with a DRM of 0–10 mm compared to 9.6% for patients with a DRM of 11–20 mm, 8.9% for a DRM of 21–30 mm, 7.0% for a DRM of 31–40 mm, 7.7% for a DRM of 41–50 mm and 8.7% for a DRM of > 50 mm. After adjustment for other independent prognostic factors, a DRM of 0–10 mm was found to have significant impact on local recurrence. The DRM had no impact on distant metastases or overall survival.Conclusion  For rectal cancer patients treated without radiotherapy, a DRM of > 10 mm is recommended.
Influence of reporting effects on the association between maternal depression and child autism spectrum disorder behaviors
Authors: Bennett Teresa , Boyle Michael , Georgiades Katholiki , Georgiades Stelios , Thompson Ann , Duku Eric , Bryson Susan , Fombonne Eric , Vaillancourt Tracy , Zwaigenbaum Lonnie , Smith Isabel , Mirenda Pat , Roberts Wendy , Volden Joanne , Waddell Charlotte ,   the Pathways in ASD Study Team, and Peter Szatmari
Published: August 2011

Background:  Maximizing measurement accuracy is an important aim in child development assessment and research. Parents are essential informants in the diagnostic process, and past research suggests that certain parental characteristics may influence how they report information about their children. This has not been studied in autism spectrum disorders (ASD) to date. We aimed, therefore, to investigate the possible effect that maternal depression might have on a mother’s reports of her child’s ASD behaviors. Using structural equation modeling, we disaggregated shared from unique variation in the association between latent variable measures of maternal depression and ASD behaviors.Methods:  Data were obtained from a study of preschoolers aged 2–4 newly diagnosed with ASD (n = 214). Information from a parent questionnaire, a semi‐structured parent interview, and a semi‐structured observational assessment was used to develop a latent variable measure of child ASD behaviors. Mothers reported on their own depression symptoms. We first modeled the covariance between maternal depression and child ASD behavior. Then, to quantify unique variation, we added covariance terms between maternal depression and the residual variation associated with the individual measures of child ASD behaviors.Results:  The model demonstrated excellent fit to the underlying data. Maternal self‐report of depression symptoms exhibited a significant association with the unique variance of the questionnaire report but not with the latent variable measure of child ASD behavior. A gradient pattern of association was demonstrated between maternal depression and the unique variance of the ASD measures: most strongly for the maternal questionnaire report, more weakly for the maternal semi‐structured interview, and to a trivial extent for the observational interview.Conclusions:  Parental depression may influence reporting of ASD behaviors in preschoolers. Shared method effects may also contribute to bias. This finding highlights the importance of obtaining multimethod reports of child ASD symptoms.
The past, the present and the preferred future for home economics education in Hong Kong
Authors: Ma Ada , Pendergast Donna 
Published: August 2011

AbstractThe future of home economics is a perennial topic on the agenda of the home economics profession. In various regions around the world, the profession as a whole has been eroded systematically as a result of curriculum reform at the compulsory and post‐compulsory levels, with the subsequent loss of higher education programmes, and, ultimately, the loss of dedicated professional home economists. This leaching degradation of home economics has implications for the concomitant loss of the unique curriculum of the subject, including the focus on consumer‐related issues. Hong Kong has not been exempted from this pattern, leading to concerns about the capacity of society to engage effectively in consumer and consumer‐related issues, and the focus in home economics has been relegated to technology. This paper provides insights into the current positioning of home economics in Hong Kong and the likely outcomes of this loss of a preferred future for the profession.
Treatment of psychosis during pregnancy – a case report and a mini-review
Authors: Nielsen René E. 
Published: August 2011

Nielsen RE. Treatment of psychosis during pregnancy – a case report and a mini-review.Objective: Describe clinical problems in treating a patient with psychotic symptoms during pregnancy by presenting a case report, and review the current evidence on antipsychotic drugs during pregnancy.Methods: The review consists of a non-systematic clinical review of current data on treatment with antipsychotics during pregnancy. The case, a 27 year old female initially diagnosed with posttraumatic stress disorder (PTSD) after a rape and emotionally unstable personality disorder, illustrates some of the common challenges a clinician meets. The patient initially discontinues all treatment as she is unsure if the drugs could have a teratogenic effect and is changed to a treatment that is regarded as safe during pregnancy.Results: The current data supports treatment with chlorpromazine although there is a risk of side effects, e.g. extrapyramidal symptoms and hypotension, but also treatment with olanzapine and risperidone. If the patient is currently treated with clozapine, this treatment should be continued, due to clozapines unique efficacy profile. Blood monitoring for six months after birth is recommended when the newborn has been exposed to clozapine treatment.Conclusion: Current evidence on treatment with antipsychotics during pregnancy is sparse, but not treating is associated with increased risks compared to treatment.
Cigarette smoking, coffee intake and alcohol consumption preceding Parkinson's disease: a case–control study
Authors: Sipetic Sandra B. , Vlajinac Hristina D. , Maksimovic Jadranka M. , Marinkovic Jelena M. , Dzoljic Eleonora D. , Ratkov Isidora S. , Kostic Vlada S. 
Published: August 2011

Objective: A case–control study was performed in Belgrade in order to investigate the association between Parkinson's disease (PD) and smoking, coffee and alcohol consumption.Methods: During the period 2001–2005, 110 new PD cases and 220 hospital controls were interviewed. Cases and controls were matched by sex, age and place of residence (urban/rural). For the analysis of data conditional univariate and multivariate logistic regression methods were used.Results: With PD were associated, independently from each other, current smoking [odds ratio (OR) = 0.44; 95% confidence interval (CI) = 0.23–0.82], alcohol consumption (OR = 4.78; 95% CI = 2.67–8.55) and coffee consumption (OR = 2.54; 95% CI = 1.36–4.75). In ever smokers the risk for PD significantly decreased with the increasing number of cigarettes smoked and with increasing duration of smoking. The risk for PD significantly increased with the increasing quantity of alcohol consumption. PD risk was significantly higher in subjects whose average daily consumption of coffee was 1 and 2–3 cups, and it was lower (but not significantly) in those whose daily coffee consumption was 4+ cups. Cases and controls did not differ in duration of alcohol and coffee consumption. The results of multivariate analyses did not substantially change after adjustment on family history positive on PD.Conclusion: The findings of this study support the hypotheses of inverse association of smoking with PD, but an inverse association with coffee was not confirmed. PD was found to be positively associated with coffee and alcohol consumption.