bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatial Atlas for Mapping Vascular Microcalcification Using 18F-NaF PET/CT: Application in Hyperphosphatemic Familial Tumoral Calcinosis
Authors: Sheppard Aaron J. , Theng Elizabeth H. , Paravastu Sriram S. , Wojnowski Natalia M. , Farhadi Faraz , Morris Michael A. , Hartley Iris R. , Gafni Rachel I. , Roszko Kelly L. , Collins Michael T. , Saboury Babak 
Published: April 2024

BACKGROUND:
Vascular calcification causes significant morbidity and occurs frequently in diseases of calcium/phosphate imbalance. Radiolabeled sodium fluoride positron emission tomography/computed tomography has emerged as a sensitive and specific method for detecting and quantifying active microcalcifications. We developed a novel technique to quantify and map total vasculature microcalcification to a common space, allowing simultaneous assessment of global disease burden and precise tracking of site-specific microcalcifications across time and individuals.

METHODS:

To develop this technique, 4 patients with hyperphosphatemic familial tumoral calcinosis, a monogenic disorder of FGF23 (fibroblast growth factor-23) deficiency with a high prevalence of vascular calcification, underwent radiolabeled sodium fluoride positron emission tomography/computed tomography imaging. One patient received serial imaging 1 year after treatment with an IL-1 (interleukin-1) antagonist. A radiolabeled sodium fluoride–based microcalcification score, as well as calcification volume, was computed at all perpendicular slices, which were then mapped onto a standardized vascular atlas. Segment-wise mCS
mean
and mCS
max
were computed to compare microcalcification score levels at predefined vascular segments within subjects.

RESULTS:
Patients with hyperphosphatemic familial tumoral calcinosis had notable peaks in microcalcification score near the aortic bifurcation and distal femoral arteries, compared with a control subject who had uniform distribution of vascular radiolabeled sodium fluoride uptake. This technique also identified microcalcification in a 17-year-old patient, who had no computed tomography–defined calcification. This technique could not only detect a decrease in microcalcification score throughout the patient treated with an IL-1 antagonist but it also identified anatomic areas that had increased responsiveness while there was no change in computed tomography–defined macrocalcification after treatment.

CONCLUSIONS:
This technique affords the ability to visualize spatial patterns of the active microcalcification process in the peripheral vasculature. Further, this technique affords the ability to track microcalcifications at precise locations not only across time but also across subjects. This technique is readily adaptable to other diseases of vascular calcification and may represent a significant advance in the field of vascular biology.
Three-Year Clinical Impact of Murray Law-Based Quantitative Flow Ratio and OCT- or FFR-Guidance in Angiographically Intermediate Coronary Lesions
Authors: Aurigemma Cristina , Ding Daixin , Tu Shengxian , Li Chunming , Yu Wei , Li Yingguang , Leone Antonio Maria , Romagnoli Enrico , Vergallo Rocco , Maino Alessandro , Trani Carlo , Wijns William , Burzotta Francesco 
Published: April 2024

BACKGROUND:
The FORZA trial (FFR or OCT Guidance to Revascularize Intermediate Coronary Stenosis Using Angioplasty) prospectively compared the use of fractional flow reserve (FFR) or optical coherence tomography (OCT) for treatment decisions and percutaneous coronary intervention (PCI) optimization in patients with angiographically intermediate coronary lesions. Murray law-based quantitative-flow-ratio (μQFR) is a novel noninvasive method for the computation of FFR. In the present study, we evaluated the clinical impact of μQFR, FFR, or OCT guidance in FORZA trial lesions at 3-year follow-up.

METHODS:
μQFR was assessed at baseline and, in the case of a decision to intervene, after (FFR- or OCT-guided) PCI. The baseline μQFR was considered the final μQFR for deferred lesions, and post-PCI μQFR value was taken as final for stented lesions. The primary end point was target vessel failure ([TVF]; cardiac death, target-vessel-related myocardial infarction, and target-vessel-revascularization) at a 3-year follow-up.

RESULTS:

A total of 419 vessels (199 OCT-guided and 220 FFR-guided) were included in the FORZA trial. μQFR was evaluated in 256 deferred lesions and 159 treated lesions (98 OCT-guided PCI and 61 FFR-guided PCI). In treated lesions, post-PCI μQFR was higher in OCT-group compared with FFR-group (median, 0.93 versus 0.91;
P
=0.023), and the post-PCI μQFR improvement was greater in FFR-group (0.14 versus 0.08;
P
<0.0001). At 3-year follow-up, OCT- and FFR-guided treatment decisions resulted in comparable TVF rate (6.7% versus 7.9%;
P
=0.617). Final μQFR was the only predictor of TVF. μQFR ≤0.89 was associated with 3× increase in TVF (11.6% versus 3.7%;
P
=0.004). PCI was a predictor of higher final μQFR (odds ratio, 0.22 [95% CI, 0.14–0.34];
P
<0.001).

CONCLUSIONS:
In vessels with angiographically intermediate coronary lesions, OCT-guided PCI resulted in comparable clinical outcomes as FFR-guided PCI. μQFR estimated at the end of diagnostic or interventional procedure predicted 3-year TVF.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01824030.
SPTLC3 Is Essential for Complex I Activity and Contributes to Ischemic Cardiomyopathy
Authors: Kovilakath Anna , Mauro Adolfo G. , Valentine Yolander A. , Raucci Frank J. , Jamil Maryam , Carter Christiane , Thompson Jeremy , Chen Qun , Beutner Gisela , Yue Yang , Allegood Jeremy , Wang Xiaoxin X. , Dail Jordan , Devarakonda Teja , Myakala Komuraiah , Windle Jolene J. , Subler Mark A. , Montefusco David , Willard Belinda , Javaheri Ali , Bernas Tytus , Mahata Sushil K. , Levi Moshe , Liu Jinze , Porter George A. , Lesnefsky Edward J. , Salloum Fadi N. , Cowart L. Ashley 
Published: April 2024

BACKGROUND:
Dysregulated metabolism of bioactive sphingolipids, including ceramides and sphingosine-1-phosphate, has been implicated in cardiovascular disease, although the specific species, disease contexts, and cellular roles are not completely understood. Sphingolipids are produced by the serine palmitoyltransferase enzyme, canonically composed of 2 subunits, SPTLC1 (serine palmitoyltransferase long chain base subunit 1) and SPTLC2 (serine palmitoyltransferase long chain base subunit 2). Noncanonical sphingolipids are produced by a more recently described subunit, SPTLC3 (serine palmitoyltransferase long chain base subunit 3).

METHODS:

The noncanonical (d16) and canonical (d18) sphingolipidome profiles in cardiac tissues of patients with end-stage ischemic cardiomyopathy and in mice with ischemic cardiomyopathy were analyzed by targeted lipidomics. Regulation of SPTLC3 by HIF1α under ischemic conditions was determined with chromatin immunoprecipitation. Transcriptomics, lipidomics, metabolomics, echocardiography, mitochondrial electron transport chain, mitochondrial membrane fluidity, and mitochondrial membrane potential were assessed in the cSPTLC3
KO
transgenic mice we generated. Furthermore, morphological and functional studies were performed on cSPTLC3
KO
mice subjected to permanent nonreperfused myocardial infarction.

RESULTS:
Herein, we report that SPTLC3 is induced in both human and mouse models of ischemic cardiomyopathy and leads to production of atypical sphingolipids bearing 16-carbon sphingoid bases, resulting in broad changes in cell sphingolipid composition. This induction is in part attributable to transcriptional regulation by HIF1α under ischemic conditions. Furthermore, cardiomyocyte-specific depletion of SPTLC3 in mice attenuates oxidative stress, fibrosis, and hypertrophy in chronic ischemia, and mice demonstrate improved cardiac function and increased survival along with increased ketone and glucose substrate metabolism utilization. Depletion of SPTLC3 mechanistically alters the membrane environment and subunit composition of mitochondrial complex I of the electron transport chain, decreasing its activity.

CONCLUSIONS:
Our findings suggest a novel essential role for SPTLC3 in electron transport chain function and a contribution to ischemic injury by regulating complex I activity.
Comparison of Incidence and Prognostic Impact of Ischemic, Major Bleeding and Heart Failure Events in Patients With Chronic Coronary Syndrome: Insights From the CORONOR Registry
Authors: Lemesle Gilles , Lamblin Nicolas , Schurtz Guillaume , Labreuche Julien , Duhamel Alain , Verdier Basile , Steg Philippe Gabriel , Bauters Christophe 
Published: April 2024

BACKGROUND:
Evaluation of the residual risk in patient with chronic coronary syndrome is challenging in daily practice. Several types of events (myocardial infarction, ischemic stroke, bleeding, and heart failure [HF]) may occur, and their impact on subsequent mortality is unclear in the era of modern evidence-based pharmacotherapy.

METHODS:
CORONOR (Suivi d’une cohorte de patients Coronariens stables en région Nord-pas-de-Calais) is a prospective multicenter cohort that enrolled 4184 consecutive unselected outpatients with chronic coronary syndrome. We analyzed the incidence, correlates, and impact of ischemic events (a composite of myocardial infarction and ischemic stroke), major bleeding (Bleeding Academic Research Consortium 3 or higher), and hospitalization for HF on subsequent patient mortality.

RESULTS:

During follow-up (median, 4.9 years), 677 patients (16.5%) died. The 5-year cumulative incidences (death as competing event) of ischemic events, major bleeding, and HF hospitalization were 6.3% (5.6%–7.1%), 3.1% (2.5%–3.6%), and 8.1% (7.3%–9%), respectively. Ischemic events, major bleeding, and HF hospitalization were each associated with all-cause mortality. Major bleeding and hospitalization for HF were associated with the highest mortality rates in the postevent period (42.4%/y and 34.7%/y, respectively) compared with incident ischemic events (13.1%/y). The age- and sex-adjusted hazard ratios for all-cause mortality were 3.57 (95% CI, 2.77–4.61), 9.88 (95% CI, 7.55–12.93), and 8.60 (95% CI, 7.15–10.35) for ischemic events, major bleeding, and hospitalization for HF, respectively (all
P
<0.001).

CONCLUSIONS:
Hospitalization for HF has become both the most frequent and one of the most ominous events among patients with chronic coronary syndrome. Although less frequent, major bleeding is strongly associated with worse patient survival. Secondary prevention should not be limited to preventing ischemic events. Minimizing bleeding and preventing HF may be at least as important.
Risk of Major Adverse Cardiovascular Events After Emergency Department Visits for Hypertensive Urgency
Authors: Liberman Ava L. , Razzak Junaid , Lappin Richard I. , Navi Babak B. , Bruce Samuel S. , Liao Vanessa , Kaiser Jed H. , Ng Catherine , Segal Alan Z. , Kamel Hooman 
Published: April 2024

BACKGROUND:
Chronic hypertension is an established long-term risk factor for major adverse cardiovascular events (MACEs). However, little is known about short-term MACE risk after hypertensive urgency, defined as an episode of acute severe hypertension without evidence of target-organ damage. We sought to evaluate the short-term risk of MACE after an emergency department (ED) visit for hypertensive urgency resulting in discharge to home.

METHODS:

We performed a case-crossover study using deidentified administrative claims data. Our case periods were 1-week intervals from 0 to 12 weeks before hospitalization for MACE. We compared ED visits for hypertensive urgency during these case periods versus equivalent control periods 1 year earlier. Hypertensive urgency and MACE components were all ascertained using previously validated
International Classification of Diseases
,
Tenth Revision Clinical Modification
codes. We used McNemar test for matched data to calculate risk ratios.

RESULTS:
Among 2 225 722 patients with MACE, 1 893 401 (85.1%) had a prior diagnosis of hypertension. There were 4644 (0.2%) patients who had at least 1 ED visit for hypertensive urgency during the 12 weeks preceding their MACE hospitalization. An ED visit for hypertensive urgency was significantly more common in the first week before MACE compared with the same chronological week 1 year earlier (risk ratio, 3.5 [95% CI, 2.9–4.2]). The association between hypertensive urgency and MACE decreased in magnitude with increasing temporal distance from MACE and was no longer significant by 11 weeks before MACE (risk ratio, 1.2 [95% CI, 0.99–1.6]).

CONCLUSIONS:
ED visits for hypertensive urgency were associated with a substantially increased short-term risk of subsequent MACE.
The Wrong Side of the River: a Cantonese Emigrant Community in the Nineteenth-Century Mobility Transition
Authors: Miles Steven B. 
Published: April 2024

Abstract
This focused study of one emigrant community in southern China explores linkages between internal and overseas migration during the nineteenth century, emphasizing both the diversity of lived experience and the contingent nature of categories that have informed the historiography of overseas Chinese migrants. Building on comparative studies that present an aggregate picture of changing migration patterns during the “mobility transition,” this microhistory shows how both preexisting and novel patterns of internal migration (urbanization, frontier migration, and military migration) shaped new strategies of overseas migration. For this particular emigrant community, new dynamics of migration in the mid-nineteenth century influenced the reputation of its emigrants, bringing about a transition from respectability to notoriety. Whereas earlier patterns of internal migration had linked this community to its neighbor on the opposite bank of the West River, new dynamics of migration in the nineteenth century bolstered the river’s role as a boundary. This community’s liminal place highlights the contingent nature of nineteenth-century tropes and current categories of overseas Chinese migrants.
A Pentecostal Third Article Theology
Authors: Studebaker Steven M. 
Published: April 2024

Abstract
This article proposes a pentecostal theology of the Holy Spirit. It argues that the Holy Spirit plays a central role in the narrative of redemption from creation to eschaton. Indeed, the telos of redemption is the outpouring of the Spirit of Pentecost that culminates in the eschatological promise of the new creation. This eschatological work of the Holy Spirit indicates the Spirit’s immanent identity and agency as the divine person who completes the fellowship of the triune God. It begins with detailing areas of traditional pentecostal theology that prevent the development of pentecostal pneumatology that reflects the central place of the Holy Spirit in pentecostal experience and the biblical narrative of redemption. It then builds the case for a pentecostal pneumatology on the Holy Spirit’s role in the narrative of redemption from creation to eschaton. It concludes with a pentecostal account of the Holy Spirit’s identity in the immanent Trinity. Throughout, it articulates this pentecostal pneumatology considering the classical pentecostal theology of Spirit baptism and traditional Western and Eastern trinitarian theologies.
“Look at Lagosians and Say I Am Going to Be in Charge”: Ideologies in the 2019 Lagos State (Nigeria) Gubernatorial Debate
Authors: Bamgbose Ganiu A. , Babalola Pedepo 
Published: April 2024

Abstract
Man, in the generic sense, is a political being whose entire life is permeated by politics. Because language plays a critical role in politics, the study was aimed at examining language as an instrument of persuasion and/or appeal in the 2019 gubernatorial debate in Lagos State. It was born out of the desire to unravel the linguistic strategies utilised by politicians to curry the electorate’s votes. Van Dijk’s (1997) socio-cognitive model of critical discourse analysis (CDA) was blended with Culpeper’s (2013) impoliteness theory to analyse the thirty-two (32) texts which were purposively sampled from the responses of the contestants. The theories were merged to establish how authors represent one another while communicating their plans. The analysis of the data revealed that the US/THEM dichotomy of the ideological square was employed by all the candidates. Findings revealed that politicians often raise very germane socio-economic issues in the polity in their presentations in a way that displays solidarity with the citizens, all in a bid to curry their votes. While lexicalisation is also another strategy employed to foreground issues to their own advantage, linguistic impoliteness (e.g., bald on record, name-calling, negative impoliteness, etc.) is deployed by politicians to whittle down opponents’ influence in order to increase theirs. The study concludes that the explication of the discursive, rhetorical, and linguistic strategies deployed by politicians helps citizens become more discerning listeners who make political choices based on convictions and not on rhetoric.
Collective Data Protection Litigation
Authors: Wörle Karl , Gstrein Oskar Josef 
Published: April 2024

Abstract
At first glance data protection litigation seems to be a niche topic. Yet, record sum compensation such as those resulting from the Meta – Cambridge Analytica lawsuit (725 million usd) reveal enormous practical relevance. This proceeding took the form of a class action, brought before a Californian court. Such collective proceedings might sweep across the Atlantic, as the EU Directive on Representative Actions introduced a new collective litigation mechanism. We commence our comparative analysis by outlining the relevant legal landscapes in the EU and the US, give an account of the latest developments, and examine relevant case law and scientific literature (paras. 1.–4.). Subsequently, the law and economics of data protection litigation are explained (para. 5.), which will serve as standard of comparison. On this basis, in para. 6. the article contrasts the efficiency of collective litigation mechanisms, enabling enforcement against data protection infringements, with the objectives of evaluating the legal status quo and distilling proposals for future legal policy.
Dressing Pope Francis: His Public Costume between Pontifical, Jesuit, and Franciscan Traditions
Authors: Pattenden Miles 
Published: April 2024

Abstract
When Jorge Bergoglio became the first Jesuit to be elected as a successor to St. Peter, it created a novel problem in papal and Jesuit history: how would a Jesuit interpret the long-standing but ever-evolving traditions of pontifical dress? This article sets out how Francis’s public sartorial choices have developed as he has negotiated his twin roles within the church. It further considers the influence of both Jesuit and Franciscan visual and material culture on the image he cultivates and the intersections between them and the imperatives of papal fashion. Finally, it considers the contribution of clothing to Francis’s image and reputation within the church and in popular media in Italy and in the wider world.
Sacred Landscapes of Greater Syria: Joseph Besson’s 1660 Jesuit Perspective
Authors: Altic Mirela 
Published: April 2024

Abstract
Joseph Besson’s 1660 account of Jesuit missions in Syria offers a rare glimpse into the region’s cultural landscape from the perspective of French Jesuits living among diverse communities of Jews, Christians (Greek-Orthodox and Catholic), and Muslims. Drawing on unpublished Jesuit relations from 1625 to 1659 and an unsigned map of Syria, this article explores Besson’s portrayal of Greater Syria, a region encompassing modern-day Syria, Lebanon, Israel, Palestine, and western Jordan, within the Ottoman empire. A detailed analysis reveals that the map is likely an original Jesuit creation, highlighting how Jesuit spirituality influenced their interpretation of physical spaces. Furthermore, the study illuminates the Jesuits’ role in shaping European views of the Orient and the Holy Land, contributing to the early development of Orientalism.
Development of yogurt products from alternative protein
Authors: Oupathumpanont O. , Wisansakkul S. 
Published: April 2024

Abstract
This research (1) developed a formula and production process for yogurt made from alternative protein, (2) studied the physical properties, nutrition, microorganisms, and consumer acceptance of yogurt made from alternative protein, and (3) assessed the shelf life of yogurt made from alternative protein. Formula development and production process factors included the ratio of bamboo worms to water (1:1 and 2:1), the amount of powdered milk (6% and 8%), and the incubation time (8 and 10 hours). The experiment was conducted using a completely randomized design CRD. Results showed that the optimal formula for producing yogurt products made from alternative protein consisted of ratio of bamboo worms to water 2:1, powered milk 8%, and incubation time 8 hours at 40 °C. Nutritional value (per 100 g) was 30.56 μg vitamin A, 70.04 mg calcium, 8.98 g protein, 2.68 g dietary fiber, and essential amino acids including 224.73 mg threonine, 333.91 mg valine, 368.75 mg lysine, and 419.82 mg leucine. The average consumer preference score was 6.79 ± 1.47. A total of 67.81% of consumers decided to buy alternative protein yogurt products, and after receiving nutritional information about alternative protein yogurt products this number increased to 89.81%. The shelf life of the product stored at 4 °C was not more than 4 weeks.
Hexaplaric Readings or Assimilations with a Hebrew Text in Göttingen’s Edition of Leviticus
Authors: Paximadi Giorgio 
Published: April 2024

Abstract
The article takes into consideration a certain number of readings contained in the Göttingen critical edition of the book of Leviticus published by J.W. Wevers in 1986. Whilst maintaining the importance of this edition, it is possible to note that in numerous points the readings chosen seem to be the most harmonized with the Hebrew text, thereby risking the loss of some particular characteristics of the LXX text that may contain interpretative elements of a theological or legislative nature. In this contribution I shall review some examples that seem significant to me in which, with differing degrees of certainty, we might suspect that such a harmonizing tendency has influenced the readings chosen by Wevers, even in some cases including the tendency to introduce Hexaplaric readings.
Looking Back at the Present
Authors: Darnbrough Leanne Rae 
Published: April 2024

Abstract
This article examines Hedwig Fechheimer’s 1914 Die Plastik der Aegypter (Egyptian Sculpture) and Tristan Tzara and Étienne Sved’s 1954 collaborative book L’Égypte face à face (Egypt Face to Face) and how, bookending the classical European avant-garde period, both took recourse to ancient Egypt to explain their present moment. While Fechheimer approaches Egyptian artwork via a nascent Cubism, Tzara and Sved reflect on ancient Egypt through nostalgic, Dada-tinted lenses. The presents of Fechheimer, Tzara, and Sved were rife with anti-Semitism and conflict; while Fechheimer avoids politics entirely Tzara and Sved do have a poignantly political purpose. In both cases time is folded, challenging teleological conceptions of historicity.