bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical Cancer Screening Program in a Muslim Country: Three‐Year Experience at The Aga Khan University Medical Center, Karachi
Authors: Rasul Saadiya , Khan Khalid S. , Rizvi Javaid H. , Hassan Sheema H. , Maniar Siddiqua 
Published: August 2010

AbstractA systematic cervical cancer screening program was initiated in January 1987 at The Aga Khan University Medical Center, Karachi, Pakistan. The 8,784 cervical smears obtained in 3 subsequent years from 8,412 consecutive women attending the gynecology and antenatal clinics were reviewed. “Positive” smears were found in 111 (1.3%) patients; 107 (1.27%) smears showed squamous epithelial dysplasia and 4 smears showed adenocarcinoma. The highest incidence of abnormal smears was found in the 45–54 years age group. Colposcopy and biopsy was performed on all patients with “positive” smears except on those with atypical or mildly dysplastic ones, in whom only the persistence of the abnormality on repeated smears was considered an indication for tissue evaluation. The histopathologic diagnosis of these biopsy specimens revealed cervical intra‐epithelial neoplasia in 60 patients and invasive cervical cancer in 6 patients.
Pharmacokinetics of Vitamin K in Mothers and Children in the Perinatal Period: Transplacental Transport of Vitamin K2 (MK‐4)
Authors: Iioka Hideaki , Moriyama Ikuko S. , Morimoto Keiko , Akada Shinobu , Hisanaga Hiroyasu , Ishihara Yuki , Ichijo Motohiko 
Published: August 2010

AbstractIn order to examine the pharmacokinetics of vitamin K2, vitamin K2 (MK‐4) was intravenously injected into mothers, and its transfer to placental tissue and the fetuses was examined. While incorporation of vitamin K2 into placental tissue was relatively active, transfer of vitamin K2 to fetal blood (cord blood) was small. So it was indicated that vitamin K2 incorporated into placental tissue from maternal blood is initially stored in the placenta and then gradually released into the fetal blood.Since vitamin K deficiency has been pointed out, release of vitamin K2 into milk was also examined. When vitamin K2 (MK‐4) was injected into mothers, the release of vitamin K2 into milk increased with time even after the plasma vitamin K2 concentration in maternal blood decreased. So the presence of a vitamin K2 concentrating mechanism in the mammary tissue was indicated.
Reconstruction of Surgical Defects Using the Gluteus Maximus Myocutaneous Flap Following Radical Vulvectomy
Authors: Ogino Masahiro , Sakamoto Takako , Inoue Jun , Dobashi Kazuyoshi , Okinaga Shoichi , Arai Kiyoshi 
Published: August 2010

AbstractRadical vulvectomy is often complicated by problems associated with insufficient closure of large skin defects involving postoperative necrosis of the suture line over the mons pubis and the inguinal areas. To resolve these problems, the present study compared radical vulvectomy (RV, 7 cases) with radical vulvectomy followed by reconstructive operation using the gluteus maximus myocutaneous flap (RVR, 5 cases). There was no significant difference in operation time and blood loss between the two groups. Three of the 7 RV patients had wound separations requiring reoperation, while only 1 patient in the RVR group did. The average hospital stay was 86 days in the RV group and 38 days in the RVR. Risks of postoperative infection and wound breakdown were reduced with the flap technique, and ambulation and rehabilitation could begin earlier in this group. Surgical wounds were stable and the quality of life after operation was improved dramatically using the flap technique.
Accuracy in Diagnosis of Ectopic Pregnancy by Transvaginal Ultrasonography
Authors: Anandakumar C. , Lee Colin S. S. , Wong Yee Chee , Chia Dawn , Rodenburg A. , Ratnam S. S. 
Published: August 2010

AbstractForty patients suspected to have ectopic pregnancy by transvaginal ultrasonography had surgery. 77.5% were confirmed to have ectopic pregnancy and 10% had other abnormal pelvic findings.The transvaginal approach appears to enable us to diagnose ectopic pregnancy at an earlier date, with the earliest diagnosis made at 4 weeks 0 days of amenorrhoea. In cases of confirmed ectopic pregnancy, the presence of a complex adnexal mass was the most common feature seen on transvaginal ultrasound and its predictability of ectopic pregnancy is enhanced by a concomitant finding of an empty uterus (95%) or free fluid in the Pouch of Douglas (94%) in the presence of a positive hCG test.The significance of transvaginal ultrasound features, and the advantages of transvaginal over transabdominal ultrasound, are discussed.
Outcome of 143 Pregnancies Conceived by Assisted Reproductive Techniques
Authors: Yang Mary H. M. , Ng Soon‐Chye , Ratnam Shan S. , Devendra Sharath , Marshall Barry , Anandakumar C. , Wong Yee‐Chee , Bongso Ariff 
Published: August 2010

AbstractOne hundred and forty‐three pregnancies conceived by assisted reproductive techniques (ART) from October 1985 to June 1989 in the National University Hospital, Singapore, resulted in 66 deliveries and 89 babies. There were 27 (18.7%) biochemical pregnancies, 44 (30.7%) clinical miscarriages and 6 (4.2%) ectopic pregnancies when total pregnancies were considered. Of those who continued pregnancy to second trimester multiple births occurred in 20 (13.3%) patients. A high incidence of vaginal bleeding and hypertension in pregnancy was noted in 32 (48.5%) patients and 18 (27.3%) patients, respectively. Caesarean section was the method of delivery in 48.5% of patients. Twenty‐six (29.2%) babies required admission to the neonatal intensive care unit. All babies except one set of twins delivered at 24 weeks of amen‐orrhoea survived. Fetal abnormality was noted in 2 cases.
Analysis of 20,119 Deliveries in Dhaka Medical College Hospital
Authors: Begum Kohinoor 
Published: August 2010

AbstractData of 20,119 deliveries in Dhaka Medical College Hospital are presented. Dhaka Medical College Hospital is the chief referral hospital in Dhaka city. The 15% of patient were 18 years of age or below and 18% were above 35 years of age or above. The 48.22% were primaegravida and 51.78% were multigravida, of these 28% were grandmultigravida. The 89% had no previous antenatal checkup. The 92.72% had cephalic presentation, 65.52% had normal vaginal delivery, 21.07% had caesarean section, 11.18% had forceps delivery. Perinatal mortality during hospital stay was 143/1,000 deliveries, maternal mortality 2,510/100,000, mainly due to eclampsia. Complications during delivery were mainly in the form of ruptured uterus (1.10%), P.P.H. (1.06%), and retained placenta (3.88%).
A Case of Successful Pregnancy and Delivery after Brain Metastasis of Choriocarcinoma
Authors: Yokota Hideo , Mabuchi Yoshiya , Hosomichi Taro , Kimura Masanori , Imai Hideaki , Sutou Kenji 
Published: August 2010

AbstractThis is report regarding a 28‐year‐old woman who conceived and delivered a healthy child following treatment for brain metastasis of choriocarcinoma in 1980 and a prolonged postoperative disease‐free period. The patient had delivered a hydatidiform mole. Eight months afterwards she was admitted to our hospital with occipital pain, vomiting and stupor, and upon CT examination was found to have a brain tumor. The surgically removed tumor was pathologically diagnosed as choriocarcinoma. Postoperative methotrexate chemotherapy rapidly lowered the preoperative urinary human chorionic gonadotrophin (19 IU/ml), and allowed restoration of the preoperative LH level, consciousness, ambulation, and manifest ovulation. Occasional mild cramps were received by continuous use of anticonvulsants which did not affect her daily life. Four and one‐half years postoperatively she conceived, and had a healthy boy weighing 2,294 g at the 39th week of gestation in June 1985. Both mother and baby have been doing well for 7 postpartum years.
Pregnancy in Association with Mitral Valve Prolapse
Authors: Jana Narayan , Vasishta Kala , Khunnu Bhawani , Dhall G. I. , Grover Anil 
Published: August 2010

AbstractMitral valve prolapse (MVP) is considered to be the most common valvular heart lesion in adult females of reproductive age. Our report reviews the obstetrical performance and outcome of 34 pregnancies in 15 women with MVP. In 12 (80%) patients cardiac lesion was suspected due to enigmatic dyspnoea and palpitation during antenatal period. Four mothers required propranolol for cardiac arrhythmias. However, all of them tolerated pregnancy and labour well. Four pregnancies (11.8%) ended in spontaneous abortion and 1 mother had intrauterine fetal death due to severe pregnancy‐induced hypertension. There were 25 (73.5%) term and 3 (8.8%) preterm neo‐nates without congenital abnormality. One preterm neonate had tracheo‐oesophageal fistula and died 6 hours after corrective surgery. The mean birth weight of 2.8 kg was appropriate for mean gestation of 38.5 weeks when compared to the Institute's reference neonatal weight curve. Infective endocarditis prophylaxis was recommended in cases having mitral regurgitation and complicated delivery. Awareness of this common cardiac lesion, thorough cardiovascular examination during pregnancy, early detection and treatment of cardiac arrhythmias if any, are the essential steps to prevent rare but dreaded maternal complications.
The Impact of Autologous Bone Marrow Transplantation on Hematopoietic Recovery after High‐Dose Cyclophosphamide, Doxorubicin and Cisplatin Chemotherapy for Patients with Gynecological Malignancies*
Authors: Murakami Masaru , Shinozuka Takao , Miyamoto Tsuyoshi , Fujii Akikazu , Tokuda Yutaka 
Published: August 2010

AbstractTwenty‐six patients with gynecological malignancies (21 ovarian and 5 uterine malignant tumors) who were treated 42 times with high‐dose cyclophosphamide, doxorubicin and cisplatin (CAP) chemotherapy with autologous bone marrow transplantation (ABMT) were assessed for the impact of predictive parameters on hematopoietic recovery. An inverse correlation was observed between the number of infused nucleated marrow cells (NMC)/kg or colony‐forming units of granulocyte‐macrophage (CFU‐GM)/kg and the leukopenic duration <1X103/μl; the correlation coefficients were r=‐0.54 and ‐0.49, respectively (p<0.001). The recovery time of platelet count to achieve more than 5times104/μl without transfusion was inversely correlated with CFU‐GM/kg (r=‐0.33, p<0.05) but not with NMC/kg. Neither the episodes of fever nor the number of chemotherapy courses performed on the patients influenced the hematopoietic recovery. The numbers of infused CFU‐GM and NMC were useful parameters of leukopoietic recovery after ABMT and high‐dose CAP chemotherapy.
Colposcopic Index of HPV and CIN Patients
Authors: Roy M.H. Sianturi 
Published: August 2010

AbstractThere were 115 patients who had atypical transformation zone on colposcopic examination which attended this study. This prospective study was held in the author's private colposcopy clinic from July 1, 1989 until December 31, 1991. The colposcopic index was used to describe the colposcopic sign of those lesions and histopathology results were adopted as the gold standard of diagnosis. This colposcopic index had an accuration rate of 95.7% compared to histopathology diagnosis.
Successful Pregnancy in a Woman with Premature Ovarian Failure
Authors: Fujii Shunsaku , Ikeda Shiroh , Tachizaki Tatsuo , Kagiya Akifumi , Saito Yoshiharu 
Published: August 2010

AbstractA case of a patient with premature ovarian failure (POF) is discussed. Ovulation failed to occur for 5 years by gonadotropin‐releasing hormone agonist (GnRHa) and human menopausal gonadotropin (hMG) treatment following estrogen‐progesterone replacement therapy. After laparoscopic ovarian biopsy, ovulation was successfully induced by hMG, although gonadotropins were not suppressed enough, and the patient achieved pregnancy.
Postpartum Hemorrhage Producing Acute Ischemic Optic Neuropathy
Authors: Sharma Ranjana , Desai Sanjiv 
Published: August 2010

AbstractA rare case of bilateral peripartum blindness due to acute ischemic optic neuropathy (AION) occurring after an episode of postpartum hemorrhage is described. Massive blood loss and the resultant hypotension was instrumental in reducing the perfusion pressure at the optic nerve head and producing ischemic damage to it.
Neoadjuvant Chemotherapy Using a Platinum, Vincristine and Peplomycin (CVP) Combination in Patients with Carcinoma of the Uterine Cervix
Authors: Shimamoto Tomihiro , Tateyama Hiromichi , Kohso Toshihiko , HamActa Masao 
Published: August 2010

AbstractNeoadjuvant chemotherapy consisting of a cis‐platinum, vincristine and peplomycin (CVP) combination has been used to treat patients with carcinoma of the uterine cervix at our departments since 1983. Twenty‐one patients are reviewed in this study. A high response rate (71.4%) was obtained with 19.0% complete and 52.4% partial responses prior to radical therapy. Survival times and the progression free interval for stage I and III disease treated with CVP show improvement compared to patients not treated with CVP. No life‐threatening toxicity related to chemotherapy was noted. This combination chemotherapy used in neoadjuvant setting warrants further study.
Tubo‐Ovarian Abscess Containing Tapeworm Proglottids and Ova: A Case Report
Authors: Pairwuti Sunsri , Ratanawichitrasin Adune , Koetsawang Amorn , Robertson Donald Ian 
Published: August 2010

AbstractWe report a case of pelvic inflammatory disease complicated by a tubo‐ovarian abscess containing Taenia spp. proglottids and ova which migrated through a fistula with the sigmoid colon.
Analysis of Jmmunosuppressive Mechanism to Cytotoxic T Lymphocyte Generation in Patients with Advanced Cancer
Authors: Maeda Nagamasa , Sagara Yusuke 
Published: August 2010

AbstractIn vitro activation of cytotoxic T lymphocytes (CTLs) in peripheral blood mono‐nuclear cells (PBMCs) of patients with advanced cancer is extremely difficult. The proportion of monocytes among PBMCs is high in this type of patient. We investigated monocytosis and the mechanism of suppression of CTL generation and obtained the following findings.1. The cell fraction ratios of PBMCs were divided into two groups: those with a higher proportion of T cells (Group I), and those with a rapid increase in monocytes and a decrease in T cells (Group II).2. CTL generation occured in Group I, but was either extremely low or not observed in Group II.3. Supernatant from the culture of monocytes obtained from Group II remarkably suppressed CTL generation.4. Statistical analysis revealed that the cancer recurrence rate over a 2‐year period was significantly higher in Group II than in Group I.These findings show that monocytes are associated with the recurrence and worsening of cancer. Furthermore, the monocytes exert this effect by releasing a humoral factor that suppresses CTL activation.
The Development of an Enzyme Immunoassay for Placental Tissue Protein 17 (PP17) and Its Clinical Significance
Authors: Maekawa Iwao , Inaba Noriyuki , Ota Yoriko , Takamizawa Hiroyoshi , Bohn Hans 
Published: August 2010

AbstractWe developed an enzyme immunoassay (EIA) for placental protein 17 (PP17) using avidin biotin binding, and measured the serum‐PP17 levels of 37 healthy men, 103 nonpregnant women, 48 pregnant women, and 86 patients with gynecologic malignancies. The mean level was 12.8 ng/m/ in healthy men and 44.2 ng/m/ in nonpregnant women (p<.05). The calculated upper limit of normal was 97.8 ng/m/ (mean + 2σ). The serum PP17 concentration was remarkedly reduced postmenopausally. Pregnant women showed a mean serum level of 19.2 ng/m/, which was significantly lower than that of nonpregnant women. Immunoserological results strongly suggest that PP17 is produced far more in the normal endometrium than in the placentae and decidua. Patients with gynecologic malignancies had obviously lower mean serum PP17 levels (8.3 —19.9 ng/m/) than those found in healthy nonpregnant women. Measurement of the serum PP17 concentration might be useful in distinguishing gynecologic malignancies from various normal conditions.
The Sources and Biochemical Characteristics of Cobalamin‐Binders in Human Amniotic Fluid*
Authors: Nakamura Kousaku , Sagawa Norimasa , Mori Takahide 
Published: August 2010

AbstractThe sources and biochemical characteristics of cobalamin‐binders in amniotic fluid were investigated. Using gel‐permeation chromatography, cobalamin‐binder, extracted from amniotic fluid at term, was recovered in a single peak with the molecular size of haptocorrin. Neonatal saliva also contained only haptocorrin. However, neonatal gastric juice contained two types of cobalamin‐binders: haptocorrin and intrinsic factor. Amniotic fluid in midtrimester contained three types of cobalamin‐binders: haptocorrin, intrinsic factor, and transcobalamin II. The cultured amnion cells secreted mainly apo‐transcobalamin II. Concentrations of both apo‐haptocorrin and salivary amylase in amniotic fluid increased as gestation advanced.These results suggest that cobalamin‐binder in amniotic fluid in midtrimester originates from the fetal salivary gland, fetal gastric mucosa, and amnion cells, and that the contribution by the fetal salivary gland increases at term, when almost all cobalamin‐binders in amniotic fluid are haptocorrin.
Maximal Cytoreductive Surgery and High Dose Cisplatin Chemotherapy for Advanced Ovarian Cancer
Authors: Ochiai Kazunori , Takakura Satoshi , Isonishi Seiji , Sasaki Hiroshi , Terashima Yoshiteru 
Published: August 2010

AbstractFifty‐eight stage III patients treated at The Jikei University Hospital were analysed retrospectively, in order to clarify the combination effect of maximal cytoreductive surgery and high dose cisplatin based chemotherapy in advanced ovarian cancer. They were divided into 4 groups by treatment they received which was as follows: Group A (n=25); total abdominal hysterectomy (TAH), bilateral salpingooophorectomy (BSO) and omentectomy (OMTX) done at primary surgery and followed by 5 courses of “low dose” CAP therapy (cyclophosphamide 200 mg/sq m, adriamycin 20 mg/sq m, cisplatin 35 mg/sq m every 4 weeks for 5 courses). Group B (n=4); TAH, BSO and OMTX carried out at primary surgery and followed by “high dose” CAP therapy (cyclophosphamide 200 mg/sq m, adriamycin 20 mg/sq m, cisplatin 70 mg/sq m, every 4 weeks for 5 courses and every 8–12 weeks for 5 courses thereafter). Group C (n=13) received TAH, BSO and OMTX at the primary operation and paraaortic and pelvic lymphadenectomy (LNX) at the second look operation (SLO) with “high dose” CAP therapy as did Group B. Group D (n=16), TAH, BSO, OMTX, LNX with maximal efforts made to reduce the size of the residual tumor to less than 2 cm at the primary surgery followed by “high dose” CAP therapy. The 3 year and 5 year survival rate of each group were as follows: Group A 15.6%, 15.6%, Group B 25.0%, 0%, Group C 81.8%, 0% and Group D 50.8%, 38.1%, respectively. Results indicate that a combination of maximal cytoreductive surgery and high dose cisplatin based chemotherapy contributes to the prognosis of advanced ovarian cancer patients.
Changes of Perinatal Statistics in a Semiurban Setup between Two Time Periods in Malaysia
Authors: Al‐Mohdzar Syed Abdullah , Haque Md. Enamul , Abdullah Wan Ariffin 
Published: August 2010

AbstractHospital University Sains Malaysia (HUSM) functions as the state referral centre and the only hospital for the state of Kelantan that can offer neonatal intensive care service. The deliveries in HUSM with grand multiparity, late booking and problems of late referrals resembles a hospital serving a semiurban rather than an urban community. A comparison between the year 1989 and 1991 showed marked improvement of perinatal mortality rate from 41.32 to 24.88, which is significantly better than the improvement achieved from 1987 to 1989 (46.0 to 41.32). This was possible due to a marked fall in the early neonatal mortality rate from 10.02 in 1989 to 5.45 in 1991 and fall in the stillbirth rate from 31.61 to 19.53.
Complications Associated with CDDP Intraperitoneal Chemotherapy
Authors: Adachi Susumu , Noda Tsuneo , Ito Kimihiko , Kiyozuka Yasuhiko , Itani Yoshio , Shintani Masashi , Hisanaga Hiroyasu , Umekage Hideshi , Nakayama Masahiro , Fujita Masayuki 
Published: August 2010

AbstractAs CDDP‐ip is known to affect intraperitoneal tumors directly, and reduce CDDP associated adverse reactions, it has been used not only for ovarian cancer but other intraperitoneal tumors. However ip chemotherapy requires catheter placement at the time of laparotomy. We investigated the complications of catheters as an intraperitoneal administration route. The subjects were 84 patients, 39 with temporary catheters and 45 with an implantable port and catheter system. Twenty‐seven percent of the temporary catheter patients experienced complications‐infection 8%, inflow obstruction 3%, leakage 5%, extrusion 8%, and severe pain 3%. Furthermore, a total of 22% of patients with an implantable port and catheter system experienced complications‐inflow obstruction 9%, infection 2%, leakage 4%, and extrusion 7%. Fortunately, no serious complications were observed at our institutions, and the complication incidence seemed lower compared to that of other institutions.
Comparative Assessment of the Effects of Subdermal Levonorgestrel Implant System and Long Acting Progestogen Injection Method on Lipid Metabolism
Authors: Anwar Mochamad , Soejono Sri Kadarsih , Maruo Takeshi , Abdullah Nadir 
Published: August 2010

AbstractIn order to compare the effects of two type of long‐acting progestogen contraceptive methods with subdermal levonorgestrel (LNG) implants and depot‐medroxy‐progesterone acetate (DMPA) injections on lipid metabolism, a clinical cohort study was performed by requiring 25 women in each group adopting either LNG implant or DMPA injection method voluntarily. After 6 months of use, serum levels of trigly‐cerides, total cholesterol, HDL‐cholesterol and LDL‐cholesterol were determined and compared between the two groups of acceptors. The mean of total cholesterol in LNG implant acceptors was significantly lower than that in DMPA injection acceptors. The mean values of HDL‐cholesterol in LNG implant acceptors (41.7± 7.7 mg/dl) and in DMPA injection acceptors (45.0±9.0 mg/dl) were in the normal range without significant difference between the two groups. The mean value of triglycerides did not differ significantly between LNG implant acceptors (77.6 ± 25.1 mg/dl) and DMPA injection acceptors (91.0±30.3 mg/dl). Serum concentrations of lipid fractions such as HDL‐cholesterol and LDL‐cholesterol in LNG implant acceptors were relatively low compared to those in DMPA injection acceptors. Since there was a comparable reduction in both total‐and HDL‐cholesterol levels in the LNG implant group, the ratio of total‐to HDL‐cholesterol, which is thought to be a factor in determining the risk of coronary artery disease, remained in the normal range (2±4.5). This suggests that the use of these two contraceptive methods with proge‐stogens does not alter the risk of development of coronary artery disease.
Risk Weighing in Twin Pregnancy
Authors: Casper Fritz W. , Seufert Rudolf J. , Brockerhoff Peter 
Published: August 2010

AbstractMultiple pregnancies are more often associated with complications than singleton pregnancies. In our retrospective study of 613 twin pregnancies the most important risk factors in twin pregnancies were premature labour before the 37th week of gestation and the premature rupture of the membrane. The increase of perinatal mortality and morbidity for twins might be primary the result of premature delivery.