bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of proppant injection condition on fracture network structure and conductivity
Authors: Bai Zhifeng , Li Mingzhong , Li Jinyong , Li Changxing 
Published: June 2024

AbstractThe hydraulic fracturing of shale reservoirs is an important topic, and adjusting the fracturing process can enhance fracturing efficiency. To analyze the effect of injection conditions on the fracture network structure and conductivity, numerical simulations and theoretical calculations are carried out based on the construction data, and the variation patterns of the fracture network parameters are determined. During the theory study, a fracture network conductivity model was obtained by combining the fracture network expansion model and the fracture diversion model. Then a numerical model was set up according to the analysis results of monitoring data. The numerical simulation results showed the fracture network structure and proppant distribution under different conditions. Throughout the simulation process, the structural parameters and conductivity of the fracture network can be determined by controlling the injection amount and adjusting the injection method, speed, and sand ratio. Results indicated that the proppant pulse frequency during the injection process was a major factor affecting the structure and conductivity of the fracture network. At the same time, a comparison of the distribution structure of the proppant revealed that although the intermittent injection of the proppant improved the flow channel, the efficiency of fracture utilization can still be improved.
Variability in wind energy on interannual and decadal scales and its influence on hydrogen energy storage
Authors: Boretti Alberto , Castelletto Stefania 
Published: June 2024

AbstractForecasting future wind electricity generation requires diverse methods and tools to estimate potential output at specific locations. This study utilizes historical meteorological data and simple models at particular sites, along with past electricity production records from selected wind farms. The interannual and decadal oscillations of wind energy production at the grid level are computed. The large‐scale, long‐term energy storage needed to achieve dispatchable electricity, addressing generation variability is assessed. For the continental United States, the estimated storage requirement is approximately 1300 GWh per GW of installed capacity. The inclusion of solar power generation and the round‐trip efficiency of energy storage positively or negatively impact this estimation.
Bioconcentration of Per- and Polyfluoroalkyl Substances and Precursors in Fathead Minnow Tissues Environmentally Exposed to Aqueous Film-Forming Foam–Contaminated Waters
Authors: Hill Nicholas I. , Becanova Jitka , Vojta Simon , Barber Larry B. , LeBlanc Denis R. , Vajda Alan M. , Pickard Heidi M. , Lohmann Rainer 
Published: June 2024

Abstract
Exposure to per- and polyfluoroalkyl substances (PFAS) has been associated with toxicity in wildlife and negative health effects in humans. Decades of fire training activity at Joint Base Cape Cod (MA, USA) incorporated the use of aqueous film-forming foam (AFFF), which resulted in long-term PFAS contamination of sediments, groundwater, and hydrologically connected surface waters. To explore the bioconcentration potential of PFAS in complex environmental mixtures, a mobile laboratory was established to evaluate the bioconcentration of PFAS from AFFF-impacted groundwater by flow-through design. Fathead minnows (n = 24) were exposed to PFAS in groundwater over a 21-day period and tissue-specific PFAS burdens in liver, kidney, and gonad were derived at three different time points. The ∑PFAS concentrations in groundwater increased from approximately 10,000 ng/L at day 1 to 36,000 ng/L at day 21. The relative abundance of PFAS in liver, kidney, and gonad shifted temporally from majority perfluoroalkyl sulfonamides (FASAs) to perfluoroalkyl sulfonates (PFSAs). By day 21, mean ∑PFAS concentrations in tissues displayed a predominance in the order of liver &gt; kidney &gt; gonad. Generally, bioconcentration factors (BCFs) for FASAs, perfluoroalkyl carboxylates (PFCAs), and fluorotelomer sulfonates (FTS) increased with degree of fluorinated carbon chain length, but this was not evident for PFSAs. Perfluorooctane sulfonamide (FOSA) displayed the highest mean BCF (8700 L/kg) in day 21 kidney. Suspect screening results revealed the presence of several perfluoroalkyl sulfinate and FASA compounds present in groundwater and in liver for which pseudo-bioconcentration factors are also reported. The bioconcentration observed for precursor compounds and PFSA derivatives detected suggests alternative pathways for terminal PFAS exposure in aquatic wildlife and humans. Environ Toxicol Chem 2024;43:1795–1806. © 2024 The Author(s). Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Flow-through dosing experiments utilizing aqueous film-forming foam (AFFF)–contaminated groundwater revealed positive linear correlations between fluorinated carbon chain length and logarithm-transformed bioconcentration factors (BCFs) for perfluoroalkyl sulfonamides identified in fathead minnow (Pimephales promelas) liver via target analysis and suspect screening using high-resolution mass spectrometry. FBSA = perfluorobutane sulfonamide; FHxSA = perfluorohexane sulfonamide; FOSA = perfluorooctane sulfonamide; FPeSA= perfluoropentane sulfonamide; FPrSA = perfluoropropane sulfonamide.
Bifidobacterium longumBL‐19 inhibits oxidative stress and inflammatory damage in the liver of mice with NAFLD by regulating the production of butyrate in the intestine
Authors: Zhang Xiajun , Xu Jingwen , Dong Xueyun , Tang Jiajun , Xie Yan , Yang Jie , Zou Limin , Wu Liang , Fan Jilong 
Published: June 2024

AbstractNonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease, but there is currently no effective treatment method. Probiotics have been used as an adjunct therapy for NAFLD, but the mechanism is not clear. This study used Bifidobacterium longum BL19 (BL‐19) to treat the NAFLD mice induced by a high‐fat diet, and explored the treatment mechanism through gut microbiota and serum metabolomics techniques. We found that BL‐19 effectively prevented rapid weight gain in NAFLD mice and reduced their overall food and energy intake, decreased liver inflammatory factors expressions, and increased the bile acid synthetase enzyme CYP7A1 and superoxide dismutase. After BL‐19 treatment, the abundances of butyric acid bacteria (Oscillospira and Coprococcus) in the feces of mice increased significantly, and the concentration of butyric acid also increased significantly. We believe that BL‐19 promotes the production of butyrate in the intestines, which in turn regulates the activity of CYP7A1 in the liver and bile acid synthesis, ultimately treating liver inflammation and lipid accumulation in NAFLD mice. Serum metabolomics results indicated that BL‐19 affected multiple pathways related to inflammation and lipid metabolism in NAFLD mice. These findings suggest that BL‐19 shows promise as an adjunct therapy for NAFLD, as it can significantly improve oxidative stress, reduce inflammation in the liver, and decrease lipid accumulation.
Ameliorating effects of Clerodendrum viscosum leaves on lead‐induced hepatotoxicity
Authors: Kabir Ehsanul , Islam Jahidul , Shila Tasnim Tabassum , Beauty Sharmin Akter , Sadi Junayed , Gofur Md. Royhan , Islam Farhadul , Hossain Shakhawoat , Nikkon Farjana , Hossain Khaled , Saud Zahangir Alam 
Published: June 2024

AbstractLead (Pb), a common toxicant is ubiquitously present in the environment. Chronic Pb exposure affects almost every organ system of human body including liver. Clerodendrum viscosum is a medicinal plant and its leaves are known to have hepatoprotective, anti‐inflammatory, and anti‐hyperglycemic activities. However, the protective effect of C. viscosum leaves against Pb‐induced hepatotoxicity is yet to be studied. Therefore, this study was designed to assess the protective effect of the aqueous extract of C. viscosum leaf (Cle) against Pb‐induced hepatotoxicity in experimental mice. Pb‐acetate was given to Pb and Pb + Cle groups interperitoneally, and Cle was supplemented to Cle and Pb + Cle groups by oral gavage. Serum biomarkers of liver function—butyrylcholinesterase (BChE), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine transaminase (ALT), antioxidant enzyme activities in hepatic tissue—superoxide dismutase (SOD), reduced glutathione reductase (rGR) and catalase (CAT), levels of transcription factor—nuclear factor erythroid 2‐related factor 2 (Nrf2), and inflammatory marker—interleukin‐6 (IL‐6) were analyzed. Additionally, histological analyses of hepatic tissues of all groups of experimental mice were performed. Pb‐treatment significantly increased ALP, AST, and ALT activities and decreased BChE activity compared to control mice. The antioxidant enzyme (SOD, rGR, and CAT) activities and expression of Nrf2 level were significantly (p < .05) decreased, while IL‐6 level was significantly (p < .05) increased in the hepatic tissue homogenates of Pb‐treated mice compared to the control group. Furthermore, histological examination revealed the disruption of hepatic tissue integrity in Pb‐treated mice. Notably, supplementation of Cle provided significant protection against the changes in the activities of liver function biomarkers and antioxidant enzymes, levels of Nrf2 and IL‐6, and disruption of hepatic tissue by Pb. Taken together the present study suggests that Cle ameliorates the hepatic toxicity caused by Pb.
Biofilm generation and antibiotic resistant profile of extensive and multidrug resistant Pseudomonas aeruginosa from burn patients in Ahvaz: A cross‐sectional study
Authors: Akrami Sousan , Ekrami Alireza , Avarvand Arshid Y. 
Published: June 2024

AbstractBackground and AimsMultidrug and extensive drug‐resistant Pseudomonas aeruginosa was extracted from burn patients referring to burn centers in southwest Iran so that biofilm generation and antibiotic resistance could be investigated.MethodsA specific primer was used to confirm all our considered 110 P. aeruginosa culture‐positive reports on 345 burn patients. The resistance of P. aeruginosa to seven antibiotics and Colistin with minimum inhibitory concentration (MIC) was assessed. Biofilm formation was assessed by the phenotypic study of specimens under Congo red agar and microtiter plate assays.ResultsOne hundred and 10 clinical P. aeruginosa isolates taken from burn wound infections were validated. Among P. aeruginosa isolates, Piperacillin, Ceftazidime, Maeropenem, Gentamycin, and Gatifloacin had the highest resistance to antibiotics, while Ticarcillin‐Clavulanic acid and Ceftolozane‐Tazobactam showed the least resistance. MICs were then evaluated via the E test. Seven isolates were resistant to colistin. Colistin reference MICs for multidrug‐resistant P. aeruginosa prevalence was 38%, while it was 22% for extensively drug‐resistant (XDR) P. aeruginosa. One P. aeruginosa was pandrug‐resistant (PDR). Under Congo red agar test, 66 isolates (67%) formed biofilms and black colonies, whereas 44 isolates (50%) had red colonies. In MTP, 76% formed biofilm. 40%, 32%, 21% of the isolates were strong, moderate, and weak biofilm formers, respectively, while 43% did not form biofilms.ConclusionThe P. aeruginosa resistance to antimicrobial agents has largely challenged the control of the infection. Accordingly, a higher resistance occurred when the isolates were transferred to the patients. Less than 50% P. aeruginosa samples generated strong biofilms. Consequently, hygienic measurements are essential to inhibit P. aeruginosa transmission to hospitalized patients.
Spatio‐temporal pattern and associate meteorological factors of airborne diseases in Bangladesh using geospatial mapping and spatial regression model
Authors: Chowdhury Arman Hossain , Rahman Md. Siddikur 
Published: June 2024

AbstractBackground and AimsAirborne diseases due to climate change pose significant public health challenges in Bangladesh. Little was known about the spatio‐temporal pattern of airborne diseases at the district level in the country. Therefore, this study aimed to investigate the spatio‐temporal pattern and associated meteorological factors of airborne diseases in Bangladesh using exploratory analysis and spatial regression models.MethodsThis study used district‐level reported cases of airborne diseases (meningococcal, measles, mumps, influenza, tuberculosis, and encephalitis) and meteorological data (temperature, relative humidity, wind speed, and precipitation) from 2017 to 2020. Geospatial mapping and spatial error regression models were utilized to analyze the data.ResultsFrom 2017 to 2020, a total of 315 meningococcal, 5159 measles, 1341 mumps, 346 influenza, 4664 tuberculosis, and 229 encephalitis cases were reported in Bangladesh. Among airborne diseases, measles demonstrated the highest prevalence, featuring a higher incidence rate in the coastal Bangladeshi districts of Lakshmipur, Patuakhali, and Cox's Bazar, as well as in Maulvibazar and Bandarban districts from 2017 to 2020. In contrast, tuberculosis (TB) emerged as the second most prevalent disease, with a higher incidence rate observed in districts such as Khagrachhari, Rajshahi, Tangail, Bogra, and Sherpur. The spatial error regression model revealed that among climate variables, mean (β = 9.56, standard error [SE]: 3.48) and maximum temperature (β = 1.19, SE: 0.40) were significant risk factors for airborne diseases in Bangladesh. Maximum temperature positively influenced measles (β = 2.74, SE: 1.39), whereas mean temperature positively influenced both meningococcal (β = 5.57, SE: 2.50) and mumps (β = 11.99, SE: 3.13) diseases.ConclusionThe findings from the study provide insights for planning early warning, prevention, and control strategies to combat airborne diseases in Bangladesh and similar endemic countries. Preventive measures and enhanced monitoring should be taken in some high‐risk districts for airborne diseases in the country.
Risk factors for self‐reported high symptom cluster burdens in patients with breast cancer undergoing chemotherapy in China: A cross‐sectional study
Authors: Huang Qingmei , Zong Xuqian , Yuan Changrong , Shang Meimei , Yan Rong , Zheng Yeping , Niu Meie , Yang Yang , Wu Fulei 
Published: June 2024

AbstractBackground and AimsFurther exploration is needed to recognize symptom clusters and categorize subgroups with distinct cluster patterns and associated risks, focusing on symptoms that are highly self‐reported by patients with breast cancer undergoing chemotherapy. This study aimed to identify subgroups and risk factors for self‐reported high symptom cluster burden among patients with breast cancer undergoing chemotherapy.MethodsA total of 647 participants who met the inclusion criteria were included in the study, with data collected on demographics, disease information, self‐reported symptoms, and psychosocial factors. Latent class analysis was utilized to identify the subgroup, while logistic regression was used to pinpoint predictive risk factors.ResultsLatent class analysis revealed three subgroups: the “high burden of all symptoms group” (n = 107, 16.54%), the “high burden of psychological symptoms group” (n = 103, 15.92%), and the “low burden of all symptoms group” (n = 437, 67.54%). Patients in the high burden of all symptom group and high burden of psychological symptom group exhibited significantly worse function outcomes (p < 0.001). Predictive risk factors for the “high burden of all symptom group” included older age, lower self‐efficacy, worse body image, and a higher financial burden. Similarly, patients with high burden of psychological symptom were more likely to have low self‐efficacy, poor body image, and a high financial burden.ConclusionThe study demonstrated the importance of giving more attention to patients with breast cancer who are at risk of developing into membership of high symptom cluster burden group.
Modified Hongteng Baijiang decoction enema improves sequelae of pelvic inflammatory disease by regulating the LIF/JAK2/STAT3 pathway and gut microbiota
Authors: Ji Xiaoli , Hu Quan , Yang Chengcheng , Huang Li , Huang Yefang , Deng Linwen , Song Xiaoqing , Zhang Yongqing , Wang Yan 
Published: June 2024

AbstractObjectiveThe sequelae of pelvic inflammatory disease (SPID) are major causes of secondary infertility. Modified Hongteng Baijiang decoction (MHTBD) has produced positive results in the treatment of patients with chronic pelvic inflammatory disease; however, its role in SPID remains elusive. Therefore, this study clarified the role of MHTBD in SPID pathogenesis.MethodsThe main components in MHTBD were analyzed by using liquid chromatography‒mass spectrometry (LC/MS). An SPID rat model was established, and the rats were treated with different doses of MHTBD (0.504 g of raw drug/kg, 1.008 g of raw drug/kg, and 2.016 g of raw drug/kg). Endometrial pinopodes were observed via scanning electron microscopy, endometrial thickness and inflammatory cell infiltration were assessed via HE staining, and the expression of estrogen receptor (ER), progesterone receptor (PR), integrin β3 (ITGB3), and CD31 in the endometrium was detected by using immunohistochemistry. Western blot analysis was used to detect the protein expression of LIF, JAK2, p‐JAK2, STAT3, and p‐STAT3 in the endometrium. Moreover, the changes in the gut microbiota were analyzed via 16S rRNA sequencing.ResultsMHTBD improved endometrial receptivity, attenuated endometrial pathologic damage, reduced inflammatory cell infiltration, decreased ER and PR expression in the endometrium, and promoted the expression of LIF, p‐JAK2, and p‐STAT3 in the endometrium (p < .05) in SPID rats. Additionally, MHTBD treatment affected the composition of the gut microbiota in SPID rats. Furthermore, MHTBD attenuated endometrial receptivity and pathological damage in SPID rats by promoting the LIF/JAK2/STAT3 pathway.ConclusionMHTBD attenuates SPID in rats by promoting the LIF/JAK2/STAT3 pathway and improving the composition of the gut microbiota. MHTBD may be a valuable drug for SPID therapy.
How does factor market distortion affect green innovation? Evidence from China's sustainable development demonstration belt
Authors: Tan Feifei , Sun Chenyu 
Published: June 2024

AbstractGreen innovation meets the simultaneous demands of green and innovation‐driven development models when it is deemed as a key to realizing a green economic transition. However, factor market distortion impedes China's green development through factor mobility and resource allocation. Under such circumstances, we detect whether and how factor market distortion affects green innovation from various perspectives in the case study of China's Sustainable Development Demonstration Belt. The findings demonstrate that the distortion has a pronounced inhibiting effect on the green innovation growth in the study area. For the eastern and more‐developed cities, factor market distortion considerably inhibits green innovation improvement, while the impact is less pronounced in the western (or central) and less developed cities. Furthermore, the factor market distortion negatively affects green innovation through some effective paths, like energy efficiency and environmental regulation. From a spatial perspective, the green innovation's spillover effect could be reduced by both the distortions of the labor market and capital market. Thus, this study would provide strong theoretical support for enhancing the factor market system and improving the multiregional green innovation power in China, as well as scientific suggestions on transitioning to China's sustainable development.
Developing tyrosine phosphoproteome libraries and dual quantification using a hybrid DIA approach
Authors: Chang Chiao‐Chun , Tai Irene‐Ya , Chan Shen‐Shian , Lin Yu‐Hsuan , Chen Yu‐Ju , Chen Yi‐Ju 
Published: June 2024

AbstractProtein tyrosine phosphorylation plays a critical role in initiating upstream cellular signaling transduction. However, the challenge in biological samples is the variability in relative concentrations (0.1%) of site‐specific tyrosine phosphorylation on proteins. To navigate these fluctuations and accurately quantify the absolute levels of tyrosine phosphosites among different samples, we reported a hybrid data‐independent acquisition‐parallel reaction monitoring (DIA‐PRM) MS technique for the robust identification and quantification of the phosphoproteome, the establishment of a comprehensive library of tyrosine phosphosites, and the specific assessment of changes in tyrosine phosphorylation. In our model study on non‐small cell lung cancer cells, our PRM strategy accomplished by a spiked‐in synthetic heavy phosphopeptide demonstrated reliable targeted quantification of the pY1197 on EGFR, revealing levels of 2.5, 4.9, and 5.3 fmol in pervanadate (PV)‐treated cells at 0, 15, and 30 min, respectively. Additionally, DIA‐extensive phosphoproteomic analysis provided 2765 tyrosine phosphosites within 14,961 global phosphosites corresponding to 1536 phosphoproteins, contributing to the phospho‐library establishment and relative quantification of phosphorylation level, especially in the PV‐treated time‐dependent increase of ErbB signaling pathway. This hybrid DIA‐PRM approach will advance the application of precise measurement of changes in multiple phosphotyrosine residues and enhance our understanding of phosphoproteomic dynamics in drug‐resistant cascades.
Performance of iron – doped activated carbon synthesised from cocoa husk as a cathode catalyst in microbial fuel cell powered Fenton process
Authors: John Juliana , Ajit Karnapa , Krishnan Haribabu , Kizhakkethil Youseph Ahammed Sherief 
Published: June 2024

AbstractBACKGROUNDBio‐electro‐Fenton (BEF) systems, specifically microbial fuel cell (MFC) driven electro‐Fenton (EF) systems, have gained significant attention in wastewater treatment in recent years. The role of the cathode catalyst in BEF is crucial, as it undergoes O2 reduction via a 2e− oxygen reduction reaction (ORR) to produce H2O2. In this study, we have harnessed the abundant lignocellulosic composition of cocoa pod husk (CPH) to prepare a novel iron‐doped heterogeneous Fenton catalyst for the BEF system. Cocoa is typically grown for its wet beans, which constitute only one third of cocoa fruit by weight, while CPH makes up about two‐thirds of the weight and is often discarded as by‐product or waste. As a result, approximately 10 million tons of CPH are produced globally each year, highlighting the potential for transforming it into a value‐added product. To date, CPH has been utilised as a natural fertiliser, soil amendment, biomass fuel, poultry and livestock feed ingredient, and more.RESULTSThe presence of mesoporous structure, iron content, oxygen containing functional groups, and prominent reduction peaks in cyclic voltammetry validated the Fe‐doped cocoa husk biochar's (Fe‐CHB) potential to act as an ORR catalyst. The BEF system achieved an open circuit voltage, current, and power densities of 0.697 V, 0.15 A/m2, and 0.040 W/m2, respectively, at an optimum resistance of 350 Ω. Optimisation of the process parameters using RSM and ANN predicted maximum dye removal efficiencies of 93.34% and 92.45%, respectively, at dye and substrate concentrations of 10 mg/L and 1 g/L. These predictions closely aligned with the experimental findings of 92.5%.CONCLUSIONThe synthesised catalyst provided large surface area, electrical conductivity, superior ORR catalytic efficiencies, and ample sites for H2O2 activation. Hence, Fe‐CHB can serve as a highly effective electrocatalyst in BEF systems. © 2024 The Author(s). Journal of Chemical Technology and Biotechnology published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry (SCI).