bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current state of evidence on ‘off-label’ therapeutic options for systemic lupus erythematosus, including biological immunosuppressive agents, in Germany, Austria and Switzerland – a consensus report
Authors: Aringer M , Burkhardt H , Burmester GR , Fischer-Betz R , Fleck M , Graninger W , Hiepe F , Jacobi AM , Kötter I , Lakomek HJ , Lorenz HM , Manger B , Schett G , Schmidt RE , Schneider M , Schulze-Koops H , Smolen JS , Specker C , Stoll T , Strangfeld A , Tony HP , Villiger PM , Voll R , Witte T , Dörner T 
Published: November 2011

Systemic lupus erythematosus (SLE) can be a severe and potentially life-threatening disease that often represents a therapeutic challenge because of its heterogeneous organ manifestations. Only glucocorticoids, chloroquine and hydroxychloroquine, azathioprine, cyclophosphamide and very recently belimumab have been approved for SLE therapy in Germany, Austria and Switzerland. Dependence on glucocorticoids and resistance to the approved therapeutic agents, as well as substantial toxicity, are frequent. Therefore, treatment considerations will include ‘off-label’ use of medication approved for other indications. In this consensus approach, an effort has been undertaken to delineate the limits of the current evidence on therapeutic options for SLE organ disease, and to agree on common practice. This has been based on the best available evidence obtained by a rigorous literature review and the authors’ own experience with available drugs derived under very similar health care conditions. Preparation of this consensus document included an initial meeting to agree upon the core agenda, a systematic literature review with subsequent formulation of a consensus and determination of the evidence level followed by collecting the level of agreement from the panel members. In addition to overarching principles, the panel have focused on the treatment of major SLE organ manifestations (lupus nephritis, arthritis, lung disease, neuropsychiatric and haematological manifestations, antiphospholipid syndrome and serositis). This consensus report is intended to support clinicians involved in the care of patients with difficult courses of SLE not responding to standard therapies by providing up-to-date information on the best available evidence.
Treatment de-escalation after mitoxantrone therapy: results of a phase IV, multicentre, open-label, randomized study of subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis
Authors: Rieckmann Peter , Heidenreich Fedor , Sailer Michael , Zettl Uwe K. , Zessack Norbert , Hartung Hans-Peter , Gold Ralf ,   on behalf of the REMAIN study group
Published: November 2011

Objective: The objective of this study was to assess the effect of treatment with interferon (IFN) β-1a, 44 µg subcutaneously (sc) three times weekly (tiw), on clinical and magnetic resonance imaging (MRI) outcomes in patients with relapsing multiple sclerosis (MS) following mitoxantrone therapy. Methods: This was an open-label, randomized, multicentre, rater-blinded, 96-week observational study conducted in Germany. Clinically stable patients with relapsing forms of MS, who had discontinued mitoxantrone treatment 1–6 months before study entry, were randomized to IFN β-1a sc 44 µg tiw, or no treatment. The primary endpoint was time to first relapse. Secondary endpoints included the number of relapse-free patients, disease activity assessed by MRI and time to 3-month confirmed Expanded Disability Status Scale (EDSS) progression, all at week 96. Results: A total of 30 patients were randomized (intent-to-treat population: 14 IFN β-1a, 15 untreated; one patient from the safety population discontinued the study after 25 days owing to an adverse event and without providing any postbaseline efficacy data, and was thus excluded from the intent-to-treat population). Overall, 71.4% (10/14) of patients in the IFN β-1a group remained relapse free over 96 weeks, versus 46.7% (7/15) in the untreated group ( p = 0.26). IFN β-1a delayed the time to first relapse versus no treatment ( p = 0.14); time to first relapse (25th percentile) was 95.4 (IFN β-1a) versus 46.0 weeks (no treatment). Confirmed EDSS progression was observed in five patients in each treatment group. Mean change in EDSS score was 0.3 in both groups ( p = 0.79). Changes in the number or volume of T1 and T2 lesions at week 96 were not significantly different between treatment groups ( p > 0.05). There were no new or unexpected adverse events related to IFN β-1a treatment. Conclusions: Several endpoints appeared to show a benefit of IFN β-1a treatment, but no significant differences could be detected owing to the small sample. Therefore, these data only permit, at best, tentative conclusions about the disease course in patients with MS after de-escalation from mitoxantrone and continuation with or without IFN β-1a. Larger confirmatory studies are required.
Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans
Authors: Srinivasan Mathangi , Flynn Ryan , Price Andrew , Ranger Ann , Browning Jeffrey L. , Taylor Patricia A. , Ritz Jerome , Antin Joseph H. , Murphy William J. , Luznik Leo , Shlomchik Mark J. , Panoskaltsis-Mortari Angela , Blazar Bruce R. 
Published: November 2011

AbstractChronic GVHD (cGVHD) poses a significant risk for HSCT patients. Preclinical development of new therapeutic modalities has been hindered by models with pathologic findings that may not simulate the development of human cGVHD. Previously, we have demonstrated that cGVHD induced by allogeneic HSCT after a conditioning regimen of cyclophosphamide and total-body radiation results in pulmonary dysfunction and airway obliteration, which leads to bronchiolitis obliterans (BO), which is pathognomonic for cGVHD of the lung. We now report cGVHD manifestations in a wide spectrum of target organs, including those with mucosal surfaces. Fibrosis was demonstrated in the lung and liver and was associated with CD4+ T cells and B220+ B-cell infiltration and alloantibody deposition. Donor bone marrow obtained from mice incapable of secreting IgG alloantibody resulted in less BO and cGVHD. Robust germinal center reactions were present at the time of cGVHD disease initiation. Blockade of germinal center formation with a lymphotoxin-receptor–immunoglobulin fusion protein suppressed cGVHD and BO. We conclude that cGVHD is caused in part by alloantibody secretion, which is associated with fibrosis and cGVHD manifestations including BO, and that treatment with a lymphotoxin-β receptor–immunoglobulin fusion protein could be beneficial for cGVHD prevention and therapy.
Cognitive performance after postoperative pituitary radiotherapy: a dosimetric study of the hippocampus and the prefrontal cortex
Authors: Brummelman Pauline , Sattler Margriet G A , Meiners Linda C , Elderson Martin F , Dullaart Robin P F , van den Berg Gerrit , Koerts Janneke , Tucha Oliver , Wolffenbuttel Bruce H R , van den Bergh Alfonsus C M , van Beek André P 
Published: November 2011

ObjectiveThe hippocampus and prefrontal cortex (PFC) are important for memory and executive functioning and are known to be sensitive to radiotherapy (RT). Radiation dosimetry relates radiation exposure to specific brain areas. The effects of various pituitary RT techniques were studied by relating detailed dosimetry of the hippocampus and PFC to cognitive performance.MethodsIn this cross-sectional design, 75 non-functioning pituitary macroadenoma (NFA) patients (61±10 years) participated and were divided into irradiated (RT+, n=30) and non-irradiated (RT−, n=45) groups. The RT+ group (who all received 25 fractions of 1.8 Gy; total dose: 45 Gy) consisted of three RT technique groups: three-field technique, n=10; four-field technique, n=15; and five-field technique, n=5. Memory and executive functioning were assessed by standardized neuropsychological tests. A reconstruction of the dose distributions for the three RT techniques was made. The RT doses on 30, 50, and 70% of the volume of the left and right hippocampus and PFC were calculated.ResultsCognitive test performance was not different between the four groups, despite differences in radiation doses applied to the hippocampi and PFC. Age at RT, time since RT, and the use of thyroid hormone varied significantly between the groups; however, they were not related to cognitive performance.ConclusionThis study showed that there were no significant differences on cognitive performance between the three-, four-, and five-field RT groups and the non-irradiated patient group. A dose–response relationship could not be established, even with a radiation dose that was higher on most of the volume of the hippocampus and PFC in case of a four-field RT technique compared with the three- and five-field RT techniques.
Tetraoctylthio- and tetraoctyloxy-substituted lead phthalocyanines: Synthesis, characterization, liquid-crystalline properties, and thin film studies
Authors: Tuncel Sinem , Basova Tamara V. , Kiselev Vitaly G. , Gromilov Sergei A. , Jushina Irina V. , Durmuş Mahmut , Gürek Ayşe G. , Ahsen Vefa 
Published: November 2011

Abstract
The Current Economic Paradigm in the Light of Financialisation
Authors: Dudziński Jerzy 
Published: November 2011

The Current Economic Paradigm in the Light of Financialisation
The paper presents the direction of the mainstream economics paradigm shift and the evidence supporting the inadequacy of its several foundations. The author puts emphasis in particular on the aspects of financialisation in international markets and its impact on the current economic life. International commodity markets provide a good reflection of the effects of financialisation. Current price movements in these markets are determined to a large extent by the engagement of financial investors, which has serious implications to the practical aspect of the economy and contributes to the changes in the nature of several basic economic categories. These markets can be, therefore, considered a certain detailed case study illustrating the general theoretical problems analysed in the paper (directions of evolution of the current economic paradigm).
An Input-Output model of residential mobility: a simulation of housing opportunities
Authors: Scholten Henk , Hooimeijer Pieter 
Published: November 2011

Un modèle d'entrées-sorties pour l'étude de la mobilité résidentielle : simulation des opportunités de logement.
Le montant total des constructions nouvelles aux Pays-Bas diminuera dans l'avenir en fonction des modifications démographiques. De plus en plus, le marché du logement existant devra répondre aux demandes du logement. En conséquence, la redistribution des programmes de construction sera de toute première importance. L'analyse des « chaînes de logements vacants » est utilisée pour la succession de locataires par habitation. La reconstitution des «chaînes de logements vacants » prises individuellement est cependant très aléatoire et manque d'appui théorique. Le modèle basé sur l'étude des arrivées et des départs, qui est décrit dans cet article, fournit une alternative et peut être utilisé pour évaluer le montant total et la composition du roulement qui résulte d'une différenciation spécifique des programmes de construction. Un pas décisif a été fait dans l'élaboration du modèle — il s'agit de la délimitation spatiale et sectorielle de sous-marchés du logement. La délimitation spatiale des sous-marchés est réalisée au moyen d'une analyse de regroupement. C'est par l'analyse loglinéaire qu'on réalise la délimitation sectorielle des sous-marchés et qu'on évalue les liens existant entre ces sous-marchés.
Les variations régionales de la structure des ménages en France
Authors: Chauviré Yvan 
Published: November 2011

À partir des données par arrondissement provenant du recensement de 1982, l'auteur étudie la répartition dans l'espace français des divers types de structures familiales existant parmi les ménages : ménages non familiaux simples (personnes seules) et complexes, ménages familiaux simples et complexes.
Il montre qu'une évolution s'est produite depuis 1962, tendant à la simplification de la structure des ménages par l'augmentation du nombre des personnes seules et des ménages familiaux simples (couples avec ou sans enfants sans « tiers »). L'article analyse enfin les types de combinaisons régionales des différentes catégories de ménages.
Fécondité et dimension des familles en Europe occidentale
Authors: Prioux France 
Published: November 2011

Fertility and Family size in Western Europe.

The trends observed since the second world war-i.e. the continuing shift to younger ages at childbearing; the increase in first and second birth order fertility, hidden by the decrease in higher birth order fertility - changed in the mid-sixties. Thus, among women born in 1945, who got married at early ages and in an overwhelming majority, the lowest rate of childlessness in history can be observed. They completed quickly their fertility, which a large part of them voluntarily limited to two children. For women born ten years later, a married couple with two children seems to be no longer a universal pattern: marriage and motherhood are rejected by some of them, postponed by others, who hesitate to have a second child. Furthermore, the stabilization of the fertility rates of third and later births could indicate the end in the decrease of large families, although most of the time at a very low level.
South European countries follow these trends with a delay of five or ten years.
Comparison of Higher Order Aberrations After Implantable Collamer Lens Implantation and Wavefront-guided LASEK in High Myopia
Authors: Shin Joo Youn , Ahn Hyunseok , Seo Kyoung Yul , Kim Eung Kweon , Kim Tae-im 
Published: November 2011

PURPOSE:
To compare changes in ocular higher order aberrations (HOAs) after Visian Implantable Collamer Lens (ICL, STAAR Surgical Co) implantation and wavefront-guided laser epithelial keratomileusis (WFG-LASEK) to correct high myopia.

METHODS:

This prospective case series comprised 30 eyes (18 patients) that underwent ICL implantation (ICL group) and 33 eyes (18 patients) that underwent WFG-LASEK (WFG-LASEK group). All eyes had spherical equivalent of −6.00 to −9.00 diopters. Entire ocular, internal optic, and corneal HOAs were measured before surgery and 3 months after surgery using a laser ray tracing aberrometer. Contrast sensitivity testing was performed in 10 eyes from each group at a photopic light level of 85 cd/m
2
and a mesopic level of 3 cd/m
2
3 months after surgery.

RESULTS:

In the ICL group, HOAs changed for the entire ocular trefoil-y, spherical aberration, internal optic spherical aberration, and corneal trefoil-y. In the WFG-LASEK group, increased HOAs were observed for total HOAs, entire ocular and corneal spherical aberration, secondary astigmatism, and tetrafoil. The ICL group had lower induced aberration values of entire ocular and corneal HOAs compared with the WFG-LASEK group. No significant differences in contrast sensitivity values between groups at the photopic level were noted; however, contrast sensitivity values were significantly lower for 3 (
P
=.01) and 6 cycles per degree (
P
<.001) in the WFG-LASEK group at the mesopic level. At the mesopic level, total HOAs, trefoil-y, spherical aberration, and secondary astigmatism were higher in the WFG-LASEK group.

CONCLUSIONS:
Implantable Collamer Lens implantation induced fewer ocular and corneal HOAs and resulted in better contrast sensitivity at mesopic levels than WFG-LASEK in eyes with high myopia.
CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma
Authors: Ramadas Ravisankar A. , Roche Marly I. , Moon James J. , Ludwig Thomas , Xavier Ramnik J. , Medoff Benjamin D. 
Published: November 2011

Abstract
CARMA1 is a lymphocyte-specific scaffold protein necessary for T cell activation. Deletion of CARMA1 prevents the development of allergic airway inflammation in a mouse model of asthma due to a defect in naive T cell activation. However, it is unknown if CARMA1 is important for effector and memory T cell responses after the initial establishment of inflammation, findings that would be more relevant to asthma therapies targeted to CARMA1. In the current study, we sought to elucidate the role of CARMA1 in T cells that have been previously activated. Using mice in which floxed CARMA1 exons can be selectively deleted in T cells by OX40-driven Cre recombinase (OX40+/CreCARMA1F/F), we report that CD4+ T cells from these mice have impaired T cell reactivation responses and NF-κB signaling in vitro. Furthermore, in an in vivo recall model of allergic airway inflammation that is dependent on memory T cell function, OX40+/CreCARMA1F/F mice have attenuated eosinophilic airway inflammation, T cell activation, and Th2 cytokine production. Using MHC class II tetramers, we demonstrate that the development and maintenance of Ag-specific memory T cells is not affected in OX40+/CreCARMA1F/F mice. In addition, adoptive transfer of Th2-polarized OX40+/CreCARMA1F/F Ag-specific CD4+ T cells into wild-type mice induces markedly less airway inflammation in response to Ag challenge than transfer of wild-type Th2 cells. These data demonstrate a novel role for CARMA1 in effector and memory T cell responses and suggest that therapeutic strategies targeting CARMA1 could help treat chronic inflammatory disorders such as asthma.
Th-1 Lymphocytes Induce Dendritic Cell Tumor Killing Activity by an IFN-γ–Dependent Mechanism
Authors: LaCasse Collin J. , Janikashvili Nona , Larmonier Claire B. , Alizadeh Darya , Hanke Neale , Kartchner Jessica , Situ Elaine , Centuori Sara , Har-Noy Michael , Bonnotte Bernard , Katsanis Emmanuel , Larmonier Nicolas 
Published: November 2011

Abstract
Dendritic cells (DCs) encompass a heterogeneous population of cells capable of orchestrating innate and adaptive immune responses. The ability of DCs to act as professional APCs has been the foundation for the development and use of these cells as vaccines in cancer immunotherapy. DCs are also endowed with the nonconventional property of directly killing tumor cells. The current study investigates the regulation of murine DC cytotoxic function by T lymphocytes. We provide evidence that CD4+ Th-1, but not Th-2, Th-17 cells, or regulatory T cells, are capable of inducing DC cytotoxic function. IFN-γ was identified as the major factor responsible for Th-1–induced DC tumoricidal activity. Tumor cell killing mediated by Th-1–activated killer DCs was dependent on inducible NO synthase expression and NO production. Importantly, Th-1–activated killer DCs were capable of presenting the acquired Ags from the killed tumor cells to T lymphocytes in vitro or in vivo. These observations offer new possibilities for the application of killer DCs in cancer immunotherapy.
Lanthanide Polyoxocationic Complexes: Experimental and Theoretical Stability Studies and Lewis Acid Catalysis
Authors: El Moll Hani , Nohra Brigitte , Mialane Pierre , Marrot Jérôme , Dupré Nathalie , Riflade Benoît , Malacria Max , Thorimbert Serge , Hasenknopf Bernold , Lacôte Emmanuel , Aparicio Pablo A. , López Xavier , Poblet Josep M. , Dolbecq Anne 
Published: November 2011

AbstractThe [ε‐PMoV8MoVI4O36(OH)4{LnIII(H2O)}4]5+ (Ln=La, Ce, Nd, Sm) polyoxocations, called εLn4, have been synthesized at room temperature as chloride salts soluble in water, MeOH, EtOH, and DMF. Rare‐earth metals can be exchanged, and 31P NMR spectroscopic studies have allowed a comparison of the affinity of the reduced {ε‐PMo12} core, thus showing that the LaIII ions have the highest affinity and that rare earths heavier than EuIII do not react with the ε‐Keggin polyoxometalate. DFT calculations provide a deeper insight into the geometries of the systems studied, thereby giving more accurate information on those compounds that suffer from disorder in crystalline form. It has also been confirmed by the hypothetical La→Gd substitution reaction energy that Ln ions beyond Eu cannot compete with La in coordinating the surface of the ε‐Keggin molybdate. Two of these clusters (Ln=La, Ce) have been tested to evidence that such systems are representative of a new efficient Lewis acid catalyst family. This is the first time that the catalytic activity of polyoxocations has been evaluated.
Unexpected Influence of Stereochemistry on the Cytotoxicity of Highly Efficient TiIV Salan Complexes: New Mechanistic Insights
Authors: Manna Cesar M. , Armony Gad , Tshuva Edit Y. 
Published: November 2011

AbstractThe effect of stereochemistry on the cytotoxicity of highly active and hydrolytically stable N‐methylated TiIV salan complexes is reported. Four bis(isopropoxo) complexes incorporating N‐methylated salan ligands with different aromatic substitution patterns have been prepared in racemic and optically active forms for the first time by ligand‐to‐metal chiral induction from trans‐diaminocyclohexyl‐based chiral ligands. The configuration of the metal center that derives from that of the ligand has an enormous influence on cytotoxicity, with the racemic mixture mostly being more active than the single enantiomers that are of either similar or different activity. This implies that the active species is a salan‐bound heterochiral polynuclear compound, interacting with a chiral target. Four additional complexes of achiral salan and chiral labile sec‐butoxo ligands, analyzed as racemic and as homochiral, revealed no influence of stereochemistry, supporting early dissociation of the labile ligands to give the polynuclear products.
The RABL5 homolog IFT22 regulates the cellular pool size and the amount of IFT particles partitioned to the flagellar compartment in Chlamydomonas reinhardtii
Authors: Silva David A. , Huang Xiaomeng , Behal Robert H. , Cole Douglas G. , Qin Hongmin 
Published: November 2011

AbstractCilia and flagella, sensory and motile structures protruding from the cell body, rely on the continuous bidirectional traffic of intraflagellar transport (IFT) particles to ferry flagellar precursors into flagella for assembly. Cells synthesize a large pool of IFT particle proteins in the cell body, but only a small portion engages in active transport within the flagella at any given time. The atypical small G protein Rab‐like 5 (RABL5) has been shown to move in an IFT‐like manner in the flagella, but its function in ciliogenesis is controversial. In this report, we demonstrate that IFT22, the Chlamydomonas reinhardtii homolog of RABL5, is a bona fide IFT particle complex B subunit. Although the amount of IFT22 remains unaffected by depletion of either complex A or B, depletion of IFT22 leads to a smaller pool of both complex A and B. Strikingly, the smaller cellular pool of IFT particles does not lead to a reduced distribution of IFT particles to flagella. Instead, the amount of IFT particle proteins, including IFT22 itself, increase in the flagella. Moreover, cells over‐expressing IFT22 also accumulate IFT particles in their flagella. Taken together, these data indicate that, in C. reinhardtii, IFT22 controls the cellular levels of both complex A and B, thus plays a critical role in determining the cellular availability of IFT particles. In addition, although IFT22 may not directly carry any precursors for flagellar assembly, it controls how many IFT particles participate in ferrying precursors into flagella. © 2011 Wiley Periodicals, Inc.
Electronic Effects of Ligands on the Cobalt(II)–Porphyrin‐Catalyzed Direct C–H Arylation of Benzene
Authors: Chan Tek Long , To Ching Tat , Liao Bei‐Sih , Liu Shiuh‐Tzung , Chan Kin Shing 
Published: November 2011

AbstractThe electronic effects of the porphyrin ligand on the cobalt(II)‐porphyrin‐catalyzed direct C–H arylation of benzene with 4‐iodotoluene were explored. The investigation was facilitated by the easy preparation of various substituted porphyrin ligands. The reaction rates were found to be dependent on the electron richness of the cobalt(II)–porphyrins. Such effects are consistent with the electronic influences on the rate‐determining aryl iodide bond cleavage.