bluuebunny/crossref_metadata_2025_split huggingface dataset:
Birgit Jürgenssen, ou le body art contre la sémiotique du Capital
Authors: Weibel Peter 
Published: August 2009

Résumé Birgit Jürgenssen introduit le féminisme dans le champ de l’art dès les années 1970. Elle se livre à une destruction en règle des assignations imposées aux femmes, celle en particulier de la « femme au foyer ». Échappant aux catégories du genre, s’inspirant du surréalisme et de l’ethnographie, elle met en lumière l’intersection entre divisions de classe, de race et de sexe. Le corps féminin devient dans ses dessins et photographies un territoire inconnu.
A Pivotal Role of Endothelial-Specific NF-κB Signaling in the Pathogenesis of Septic Shock and Septic Vascular Dysfunction
Authors: Ding Jianqiang , Song Dongmei , Ye Xiaobing , Liu Shu Fang 
Published: August 2009

Abstract
Although the role of NF-κB in the pathogenesis of sepsis and septic shock has been extensively studied, little is known about the causative contribution of endothelial-intrinsic NF-κB to these pathological processes. In this study, we used transgenic (TG) mice (on FVB genetic background) that conditionally overexpress the NF-κB inhibitor, mutant I-κBα, selectively on endothelium and their transgene-negative littermates (wild type (WT)) to define the causative role of endothelial-specific NF-κB signaling in septic shock and septic vascular dysfunction. In WT mice, LPS challenge caused systemic hypotension, a significantly blunted vasoconstrictor response to norepinephrine, and an impaired endothelium-dependent vasodilator response to acetylcholine, concomitant with a markedly increased aortic inducible NO synthase expression, significantly elevated plasma and aortic levels of nitrite/nitrate, increased aortic TNF-α expression, and decreased aortic endothelial NO synthase (eNOS) expression. In TG mice whose endothelial NF-κB was selectively blocked, LPS caused significantly less hypotension and no impairments in vasoconstrictor and endothelium-dependent vasodilator responses, associated with significantly reduced aortic inducible NO synthase expression, decreased plasma and aortic levels of nitrite/nitrate, reduced aortic TNF-α expression, and increased aortic eNOS expression. TNF-α knockout mice prevented LPS-induced eNOS down-regulation. WT mice subjected to cecal ligation and puncture showed significant systemic hypotension, which was prevented in TG mice. Our data show that selective blockade of endothelial-intrinsic NF-κB pathway is sufficient to abrogate the cascades of molecular events that lead to septic shock and septic vascular dysfunction, demonstrating a pivotal role of endothelial-specific NF-κB signaling in the pathogenesis of septic shock and septic vascular dysfunction.
Cognitive burden of survey questions and response times: A psycholinguistic experiment
Authors: Lenzner Timo , Kaczmirek Lars , Lenzner Alwine 
Published: August 2009

AbstractAn important objective in survey question design is to write clear questions that respondents find easy to understand and to answer. This contribution identifies the factors that influence question clarity. Theoretical and empirical evidence from psycholinguistics suggests that specific text features (e.g., low‐frequency words (LFRWs), left‐embedded syntax) cause comprehension difficulties and impose a high cognitive burden on respondents. To examine the effect of seven different text features on question clarity, an online experiment was conducted in which well‐formulated questions were compared to suboptimal counterparts. The cognitive burden of the questions was assessed with response times. Data quality was compared in terms of drop‐out rates and survey satisficing behaviour. The results show that at least six of the text features are relevant for the clarity of a question. We provide a detailed explanation of these text features and advise survey designers to avoid them when crafting questions. Copyright © 2009 John Wiley & Sons, Ltd.
Social anxiety moderates memory conformity in adolescents
Authors: Wright Daniel B. , London Kamala , Waechter Michael 
Published: August 2009

AbstractWhen two people view the same event and later try to remember it together, what one person says affects what the other person reports. A model is presented which predicts that this memory conformity effect will be moderated, in different ways, by two components of social anxiety. People with higher fear of negative evaluation should be more influenced by their peers than others, but those with higher social anxiety related to avoiding social situations may be less influenced by their peers than others. Pairs of adolescent‐aged participants took part in a face recognition study. For each trial one person responded and then the next person responded. The effect of what the first person said on the second person's response was measured; the size of the effect was moderated by the social anxiety measures as predicted by the model. This is the first study showing the relationship between social anxiety and memory suggestibility. Copyright © 2009 John Wiley & Sons, Ltd.
Positive and negative effects of physical context reinstatement on eyewitness recall and identification
Authors: Wong Carol K. , Read J. Don 
Published: August 2009

AbstractThe impact of context reinstatement (CR) on eyewitness recall and identification was explored in this study. Participants viewed a video of a staged theft and, following a 1‐week interval, were asked to identify the culprit and recall the event in either the same or in a different physical environment. Results suggested that CR enhanced the perceived familiarity of the lineup members, which in turn increased participants' willingness to identify someone in the lineup. Although CR significantly improved facial discrimination and identification accuracy when the target was present, it also increased confidence ratings beyond that warranted by the increase in accuracy. In terms of recall, reinstating the study context improved participants' free recall of both central and peripheral details and cued recall of peripheral details. The results were consistent with a (mis)attribution of familiarity and the outshining hypothesis. Copyright © 2009 John Wiley & Sons, Ltd.
Can fabricated evidence induce false eyewitness testimony?
Authors: Wade Kimberley A. , Green Sarah L. , Nash Robert A. 
Published: August 2009

AbstractFalse information can influence people's beliefs and memories. But can fabricated evidence induce individuals to accuse another person of doing something they never did? We examined whether exposure to a fabricated video could produce false eyewitness testimony. Subjects completed a gambling task alongside a confederate subject, and later we falsely told subjects that their partner had cheated on the task. Some subjects viewed a digitally manipulated video of their partner cheating; some were told that video evidence of the cheating exists; and others were not told anything about video evidence. Subjects were asked to sign a statement confirming that they witnessed the incident and that their corroboration could be used in disciplinary action against the accused. See‐video subjects were three times more likely to sign the statement than Told‐video and Control subjects. Fabricated evidence may, indeed, produce false eyewitness testimony; we discuss probable cognitive mechanisms. Copyright © 2009 John Wiley & Sons, Ltd.
Modeling of the catalytic removal of CO and NO in dry combustion gases
Authors: Treviño C. , Prince J. C. 
Published: August 2009

AbstractCatalytic removal of pollutants in dry combustion gases in a planar stagnation‐point flow over a platinum foil is studied using both numerical and analytical tools. The governing equations have been numerically integrated with the Newton technique, and the response curve has been obtained as functions of temperature and the mixture concentrations. Using the appropriate stoichiometry, the additional oxygen needed to reduce the NO and to achieve complete oxidation of CO has been obtained. The asymptotic analysis leads to an algebraic equation for the surface coverage of empty sites as a function of two nondimensional parameters: the mass transfer number, relating the residence time to the chemical time (sort of Damköhler number), and a parameter, which relates the desorption rate to the adsorption rate of carbon monoxide and depends strongly on temperature. Critical conditions of ignition (light‐off) and extinction are identified and closed form solutions are obtained for these phenomena. © 2009 American Institute of Chemical Engineers AIChE J, 2010
Facial clefting and oroauditory pathway manifestations in ankyloblepharon–ectodermal defects‐cleft lip/palate (AEC) syndrome
Authors: Cole Patrick , Hatef Daniel A. , Kaufman Yoav , Magruder Amy , Bree Alanna , Friedman Ellen , Sindwani Raj , Hollier Larry H. 
Published: August 2009

AbstractAnkyloblepharon–ectodermal defects‐cleft lip/palate (AEC) Syndrome is a rare disorder characterized by ectodermal dysplasia, along with other malformations such as cleft lip and palate, and various secondary issues such as chronic sinusitis, otitis media, and conductive hearing loss (CHL). The International Research Symposium for AEC Syndrome convened at Baylor College of Medicine in Houston, Texas. Patients with a suspected diagnosis of AEC syndrome attended, and members of the dental, dermatology, plastic surgery, otolaryngology, and audiology services examined each patient. Eighteen patients with a diagnosis of AEC were evaluated. Mean age was 7.5 years (range: 4 months–30 years). Fourteen of the 15 subjects tested (93.33%) demonstrated CHL, with seven showing moderate to severe hearing deficits (41–90 dB). Nine of 13 respondents reported hoareness or voice problems; 8 were noted to display this on examination. Fourteen of 16 subjects reported speech was below average for age; 8 were in speech therapy. All 18 subjects reported a history of otitis externa or otitis media. Eleven of the subjects (61.11%) required myringotomy and pressure equalizing (PE) tubes. All patients demonstrated cleft palate defects. Of these, 16 (94.11%) presented with clefting of the soft palate, and 10 (58.82%) showed hard palate defects. Three subjects (16.67%) were noted to have submucous clefts. Our experience leads us to propose that while the oroauditory problems in those with AEC syndrome is likely multifactorial, many issues may stem from palatal clefting. Despite this, some abnormalities persist following surgical cleft closure, which indicates other complicating factors are also involved. © 2009 Wiley‐Liss, Inc.
Beauvericin Decreases Cell Viability of Wheat
Authors: Šrobárová Antonia , da Silva Jaime A. Teixeira , Kogan Grigorij , Ritieni Alberto , Santini Antonello 
Published: August 2009

AbstractRecently, beauvericin (BEA) has been recognized as an important toxic compound synthesized by several Fusarium strains, infecting maize, wheat, and rice, worldwide. The effects of BEA on mammalian cells have been studied; however, its effects on the function of host plant cells are largely unknown. The purpose of our work was to assess whether BEA can affect the root and leaf cells of wheat cultivar (cv.) ‘Arina’ seedlings, using a cytotoxicity assay and fluorescence microscopy. Toxigenicity during wheat germination was higher in BEA‐treated wheat seedlings than in non‐treated seedlings (control). Leaf primordial, situated at the base and the tips of treated leaves, were more affected by BEA compared to the control when assayed in medium for cell viability measured by luminescent equipment. BEA‐Treated plant cells secrete adenosine triphosphate (ATP) to the extracellular matrix and invoke more luminescence by luciferase than the non‐treated seedlings. Our results were confirmed by fluorescence microscopy following ‘4′,6‐diamidino‐2‐phenylindole’ (DAPI) staining and by confocal microscopy. In addition, the bioluminescent protein luciferase was observed in the intracellular space indicating presence of ATP. The incidence of nuclear fragmentation increased significantly in cells of seedlings treated with BEA at 40 μM concentration implying that the intracellular phytotoxin BEA plays an important role, possibly as a mediator in cell‐death signalling.
Colomitides A and B: Novel Ketals with an Unusual 2,7‐Dioxabicyclo[3.2.1]octane Ring System from the Aquatic Fungus YMF 1.01029
Authors: Dong Jin‐Yan , Wang Li‐Mei , Song Hong‐Chuang , Shen Kai‐Ze , Zhou Yong‐Ping , Wang Le , Zhang Ke‐Qin 
Published: August 2009

AbstractTwo novel diastereoisomeric bicyclic ketals, colomitides A and B (1 and 2, resp.), together with the known (4RS)‐3,4‐dihydro‐4,8‐dihydroxynaphthalen‐1(2H)‐one (3) and preussomerin E (4), were isolated from liquid cultures of an unidentified freshwater fungus YMF 1.01029. Colomitides possess an unusual 2,7‐dioxabicyclo[3.2.1]octane skeleton. The chemical structures and relative configurations of compounds 1 and 2 were elucidated by spectroscopic means, including 2D‐NMR (HMBC, HMQC, TOCSY, ROESY, and 1H,1H‐COSY). Compounds 1, 2, and 4 showed noticeable antifungal and antibacterial activities.
Immunomodulatory Activity of 3β,6β‐Dihydroxyolean‐12‐en‐27‐oic Acid in Tumor‐Bearing Mice
Authors: Deng Wen , Sun Hong‐Xiang , Chen Feng‐Yang , Yao Min‐Li 
Published: August 2009

Abstract3β,6β‐Dihydroxyolean‐12‐en‐27‐oic acid (1) is a pentacyclic triterpenoid isolated from the rhizomes of Astilbe chinensis. To evaluate the in vivo antitumor potential and to elucidate its immunological mechanisms, effect of 1 on the growth of mouse‐transplantable tumors, and the immune response in naive and tumor‐bearing mice were investigated. The mice inoculated with mouse tumor cell lines were orally treated with 1 at the doses of 40, 60, and 80 mg/kg for 10 days. The effects of 1 on the growth of mouse‐transplantable S180 sarcoma and H22 hepatoma, splenocyte proliferation, cytotoxic T lymphocyte (CTL) activity, natural killer (NK) cell activity, and production of interleukin‐2 (IL‐2) from splenocytes in S180‐bearing mice were measured. Furthermore, the effect of 1 on 2,4‐dinitrofluorobenzene (DNFB)‐induced delayed‐type hypersensitivity (DTH) reactions and the sheep red blood cell (SRBC)‐induced antibody response in naive mice were also studied. Compound 1 could not only significantly inhibit the growth of mouse transplantable S180 sarcoma and H22 hepatoma, increase splenocytes proliferation, CTL and NK cell activity, and the level of IL‐2 secreted by splenocytes in tumor‐bearing mice, but also remarkably promote the DTH reaction and enhance anti‐SRBC antibody titers in naive mice. These results suggested that 1 could improve both cellular and humoral immune response, and could act as antitumor agent with immunomodulatory activity.
The Effect of an Amino‐Acid Bridge on Binding Affinity and Cleavage Efficiency of Pyrenyl‐Macrocyclic Polyamine Conjugates toward DNA
Authors: Lu Qiao‐Sen , Huang Yu , Li Jing , Zhang Zhong‐Wei , Lin Hong‐Hui , Yu Xiao‐Qi 
Published: August 2009

AbstractA series of pyrenyl‐macrocyclic polyamines 5a–5c have been prepared and characterized. Their DNA‐cleavage properties were examined under physiological conditions. Without the presence of other additives, the DNA cleavage ability of 5a–5c showed the order of 5c>5a>5b. Absorption and fluorescence experiments showed the binding affinity of 5a–5c to DNA. The interactions of 5a–5c with CT‐DNA indicated that the DNA binding ability followed an order according to their cleavage efficiency. All the results indicated that the structures of amino‐acid bridge in the ligands may affect the DNA binding and cleavage ability. The cleavage‐mechanism studies indicated that singlet oxygen and superoxide free radicals were involved in the catalytic DNA cleavage process.
Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole
Authors: Bezerra Daniel P. , Filho José D. B. Marinho , Alves Ana Paula N. N. , Pessoa Cláudia , de Moraes Manoel O. , Pessoa Otília Deusdênia L. , Torres Maria Conceição M. , Silveira Edilberto R. , Viana Francisco A. , Costa‐Lotufo Letícia V. 
Published: August 2009

AbstractCroton regelianus Muell. Arg., popularly known as ‘velame‐de‐cheiro’, is a native plant from the Northeast of Brazil used in folk medicine to treat diseases of different kinds, including malignant tumors. In this study, the in vitro and in vivo antitumor effects of the essential oil from the leaves of C. regelianus and ascaridole, one of the main constituents, were investigated. In vitro, the essential oil and ascaridole displayed cytotoxicity, showing IC50 values in the range of 22.2 to 48.0 μg/ml in HL‐60 and SF‐295 cell lines for the essential oil, and 6.3 to 18.4 μg/ml in HL‐60 and HCT‐8 cells lines for ascaridole, respectively. The in vivo study, using sarcoma 180 as a tumor model, demonstrated inhibition rates of 28.1 and 31.8% for essential oil, at the 50 and 100 mg/kg, while ascaridole inhibition rates were 33.9% at 10 mg/kg and 33.3% at 20‐mg/kg doses. Histopathological examination showed that the organs were only weakly affected by the treatment. In conclusion, ascaridole has an interesting antitumor activity in sarcoma 180 murine model, probably related to the described cytotoxic activity, and, moreover, its presence in the essential oil from the leaves of C. regelianus could explain, at least in part, the ethnopharmacological use of this plant in the treatment of cancer.
Cardioprotective Effect of ‘Methylamine Irisolidone’, a New Compound, in Hypoxia/Reoxygenation Injury in Cultured Rat Cardiac Myocytes
Authors: Mu Yan‐Ling , Xie Yan‐Ying , Zhou Ling , Zhong Ying , Liu Lu , Bai Hong , Wang Yuan‐Shu , Zhang Xiu‐Mei 
Published: August 2009

Abstract‘Methylamine irisolidone’ (=5,7‐dihydroxy‐6‐methoxy‐3‐(4‐methoxyphenyl)‐8‐[(methylamino)methyl]‐4H‐[1]benzopyran‐4‐one), a new compound, is a structurally modified kakkalide with good water solubility. In this study, we investigated its effect on hypoxia/reoxygenation (H/R) injury in cultured rat cardiac myocytes. The results showed that methylamine irisolidone could significantly inhibit lactate dehydrogenase (LDH) release, enhance the mitochondrial membrane potential, decrease intracellular calcium (Ca2+) associated with the attenuation of reactive oxygen species (ROS) generation, reduce contents of malondialdehyde (MDA), and increase the activity of superoxide dismutase (SOD) after H/R in a dose‐dependent manner. The present study demonstrated that methylamine irisolidone can directly protect cardiomyocytes against H/R injury, primarily as a result of reduction of the intracellular Ca2+ overload coincident with an attenuation of ROS generation and ROS‐mediated lipid peroxidation, which may contribute to the preservation of mitochondrion function and antioxidant against H/R injury.
An Antifungal Tetrapeptide from the Culture of Penicillium canescens
Authors: Bertinetti Brenda V. , Peña Nora I. , Cabrera Gabriela M. 
Published: August 2009

AbstractA new tetrapeptide D‐Phe‐L‐Val‐D‐Val‐L‐Tyr (1), along with three known diketopiperazines and pseurotin A, were isolated from the culture of Penicillium canescens, collected from pollen from beehives, in a screening for new antimicrobial products from unexplored sources. The structure of the tetrapeptide, which exhibits antifungal activity comparable with that of the commercial product benomyl against the soybean phytopathogen Fusarium virguliforme, was determined by spectroscopic (2D‐NMR, and MS and MS/MS) and chemical methods, and the sequence was confirmed by comparison with authentic synthetic isomeric peptides.
Cycloartane Triterpenes from Dikamali, the Gum Resin of Gardenia gummifera and Gardenia lucida
Authors: Kunert Olaf , Sreekanth Gandhe , Babu Gummadi Sreedhar , Rao Belvotagi Venkat Rao Adavi , Radhakishan Marupaka , Kumar Bobbala Ravi , Saf Robert , Rao Achanta Venkata Narasimha Appa , Schühly Wolfgang 
Published: August 2009

AbstractWe report on the chemical investigation of dikamali gum, which is the resin of Gardenia gummifera and G. lucida (Rubiaceae). Six new cycloartane triterpenes, dikamaliartanes A–F (1–6, resp.), together with a known flavonoid (7), were isolated and identified by NMR spectroscopy. All six cycloartanes are characterized by an open A‐ring with a free COOH group at C(3). In four of them, the C‐atoms C(23)–C(27) form a 4‐methylfuran‐2‐yl moiety. Bacterial assays using Staphylococcus aureus, Candida albicans, and Mycobacteria have been carried out but did not reveal significant activity.
Partition Coefficient and Molecular Flexibility: The Concept of Lipophilicity Space
Authors: Vistoli Giulio , Pedretti Alessandro , Testa Bernard 
Published: August 2009

AbstractThe rationale of this study was to investigate molecular flexibility and its influence on physicochemical properties with a view to uncovering additional information on the fuzzy concept of dynamic molecular structure. Indeed, it is now known that computed molecular interaction fields (MIFs) such as molecular electrostatic potentials (MEPs) and lipophilicity potentials (MLPs) are conformation‐dependent, as are dipole moments. A database of 125 compounds was used whose conformational space was explored, while conformation‐dependent parameters were computed for each non‐redundant conformer found in the conformational space of the compounds. These parameters were the virtual log P (log PMLP, calculated by a MLP approach), the apolar surface area (ASA), polar surface area (PSA), and solvent‐accessible surface (SAS). For each compound, the range taken by each parameter (its property space) was divided by the number of rotors taken as an index of flexibility, yielding a parameter termed ‘molecular sensitivity’. This parameter was poorly correlated with others (i.e., it contains novel information) and showed the compounds to fall into two broad classes. ‘Sensitive’ molecules are those whose computed property ranges are markedly sensitive to conformational effects, whereas ‘insensitive’ (in fact, less sensitive) molecules have property ranges which are comparatively less affected by conformational fluctuations. A pharmacokinetic application is presented.
Transcatheter pulmonary valve implantation using the edwards SAPIEN™ transcatheter heart valve
Authors: Boone Robert H. , Webb John G. , Horlick Eric , Benson Lee , Cao Qi‐Ling , Nadeem N. , Kiess Marla , Hijazi Ziyad M. 
Published: August 2009

AbstractBackground:Conduits placed in the right ventricular outflow tract (RVOT) have limited longevity which often requires increasingly complex reoperations. Transcatheter pulmonary valve implantation improves conduit hemodynamics through a minimally invasive approach. We present data for 7 patients treated with the Edwards SAPIEN™ transcatheter heart valve (THV).Patients:Patients' ranged in age from 16 to 52 years, one was female, and all had NYHA class II‐III symptoms. Patients had pulmonary homografts that had been placed 2–25 years earlier during the Ross procedure (n = 4), repaired double outlet right ventricle with situs inversus (n = 1), or Rastelli repair for D‐TGA, pulmonary atresia, and ventricular septal defect (n = 2). Patients had either severe pulmonary stenosis and/or moderate to severe pulmonary regurgitation.Results:All patients had successful percutaneous implantation of the 23 mm SAPIEN™ THV under general anesthesia. Fluoroscopy times ranged from 16 to 49 mins and procedure times ranged from 110 to 237 mins. The RV:systemic pressure ratio decreased from 78 ± 18 to 39 ± 8%, the RVOT gradient improved from 60.7 ± 24.3 to 14.9 ± 6.9 mm Hg, no patients had pulmonary insufficiency, and all patients had symptom improvement. At a maximum follow‐up of 3.5 years (median 22.5 months), Doppler peak gradients ranged from 7–36 mm Hg, and there is no evidence of late stent fracture or structural valve failure.Conclusion:The SAPIEN™ THV can be used successfully in the treatment of patients with right ventricle to pulmonary artery homograft failure. The valve is durable to at least 3.5 years without stent fracture or regurgitation. Clinical trials are underway to assess the long‐term safety and efficacy of this valve. © 2009 Wiley‐Liss, Inc.