bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac standstill for cerebral aneurysms in 103 patients: an update on the experience at the Barrow Neurological Institute
Authors: Ponce Francisco A. , Spetzler Robert F. , Han Patrick P. , Wait Scott D. , Killory Brendan D. , Nakaji Peter , Zabramski Joseph M. 
Published: October 2010

Object
The aim of this study was to clarify the surgical indications, risks, and long-term clinical outcomes associated with the use of deep hypothermic circulatory arrest for the surgical treatment of intracranial aneurysms.

Methods
The authors retrospectively reviewed 105 deep hypothermic circulatory arrest procedures performed in 103 patients (64 females and 39 males, with a mean age of 44.8 years) to treat 104 separate aneurysms. Patients' clinical histories, radiographs, and operative reports were evaluated. There were 97 posterior circulation aneurysms: at the basilar apex in 60 patients, midbasilar artery in 21, vertebrobasilar junction in 11, superior cerebellar artery in 4, and posterior cerebral artery in 1. Seven patients harbored anterior circulation aneurysms. Two additional patients harbored nonaneurysmal lesions.

Results
Perioperatively, 14 patients (14%) died. Five patients (5%) were lost to late follow-up. At a mean long-term follow-up of 9.7 years, 65 patients (63%) had the same or a better status after surgical intervention, 10 (10%) were worse, and 9 (9%) had died. There were 19 cases (18%) of permanent or severe complications. The combined rate of permanent treatment-related morbidity and mortality was 32%. The mean late follow-up Glasgow Outcome Scale score was 4, and the annual hemorrhage rate after microsurgical clipping during cardiac standstill was 0.5%/year. Ninety-two percent of patients required no further treatment of their aneurysm at the long-term follow-up.

Conclusions
Cardiac standstill remains an important treatment option for a small subset of complex and giant posterior circulation aneurysms. Compared with the natural history of the disease, the risk associated with this procedure is acceptable.
Progressive aneurysm development following hemodynamic insult
Authors: Meng Hui , Metaxa Eleni , Gao Ling , Liaw Nicholas , Natarajan Sabareesh K. , Swartz Daniel D. , Siddiqui Adnan H. , Kolega John , Mocco J 
Published: October 2010

Object
Hemodynamic insult has been speculated to be a key factor in intracranial aneurysm formation; however, it is unclear whether a sustained insult is necessary. The authors examined whether aneurysmal degradation would continue despite the normalization of wall shear stress (WSS) by adaptive outward vascular remodeling.

Methods
Twenty-five rabbits underwent either sham operation (5 animals) or bilateral common carotid artery ligation (20 animals) to augment basilar artery (BA) flow. Basilar termini (BTs) were harvested at 5 days and 3, 12, and 27 weeks postoperation. Histological changes at the BTs were quantified using an aneurysm development score (ADS) wherein the luminal length of the vessel wall exhibiting internal elastic lamina (IEL) loss, media thinning (> 30% media loss), and bulging was multiplied by the percentage of media thinning divided by the BA diameter. This score and its component variables were evaluated over the specified time points and compared with the WSS time course obtained from multiple angiography and BA flow velocity measurements.

Results
Serial examination of histological sections from the ligation group (17 rabbits survived the procedure) demonstrated localized, progressive, degenerative, and aneurysmal changes at the BTs. Prominent IEL loss was observed in BT specimens from all ligated animals. Media thinning and luminal bulging significantly progressed over the 27-week follow-up. The composite ADS significantly increased over the study period, indicating progressive aneurysm development, although the WSS returned to preligation baseline values within 5 weeks of ligation.

Conclusions
Hemodynamic insult can elicit a pathological vascular response leading to a self-sustaining aneurysmal remodeling that does not require persistence of the original inciting factor to continue its pathological progression.
Natural course of intracranial arterial dissections
Authors: Mizutani Tohru 
Published: October 2010

Object
Noninvasive neuroimaging techniques are increasingly identifying unruptured intracranial arterial dissections (IADs) at examination for headache or ischemic symptoms. Approximately 3% of cases of aneurysmal subarachnoid hemorrhage (SAH) are caused by IADs in Japan, but the natural history of unruptured IADs is not known.

Methods
Clinical data obtained in 190 patients with 206 IADs were retrospectively analyzed on the basis of long-time follow-up of geometry and clinical event. The IADs were divided into an unruptured group and SAH group depending on the patient's clinical status at the initial diagnosis. Day 0 was defined as the day preceding diagnosis of IAD—that is, the day of symptom onset. This was retrospectively determined from the clinical history.

Results
The 206 IADs included 98 unruptured lesions and 108 SAH. In both groups, the vertebral artery was the most frequent site. In the unruptured group, 93 IADs were followed for a mean of 3.44 years. The mean interval between symptom onset (Day 0) and neuroimaging diagnosis was 9.8 days. Subsequent geometry change was seen in 78 (83.9%) of 93 IADs. Major change was almost completed within 2 months, and complete normalization was seen on neuroimaging in 17 (18.3%) of 93 IADs, with the earliest on Day 15. Rupture of the IAD in the unruptured group occurred in only 1 patient on Day 11.
In the SAH group, 84 of the 108 patients complained of preceding headache before onset of SAH. In 81 (96.4%) of the 84 patients, SAH occurred on Day 0–3 with the latest on Day 11. In all patients in the unruptured and SAH groups, the latest day of SAH from the onset of preceding headache was Day 11.

Conclusions
Most IADs causing SAH bleed within a few days of occurrence. Most IADs that are unruptured already have little risk for bleeding at diagnosis because of the repair process. Intracranial arterial dissections may be much more common than previously thought, and the majority may occur and heal without symptom manifestation.
Gamma Knife surgery for subependymal giant cell astrocytomas
Authors: Park Kyung-Jae , Kano Hideyuki , Kondziolka Douglas , Niranjan Ajay , Flickinger John C. , Lunsford L. Dade 
Published: October 2010

Object
The authors report their experience of using Gamma Knife surgery (GKS) in patients with subependymal giant cell astrocytoma (SEGA).

Methods
Over a 20-year period, the authors identified 6 patients with SEGAs who were eligible for GKS. The median patient age was 16.5 years (range 7–55 years). In 4 patients, GKS was used as a primary management therapy. One patient underwent radiosurgery for recurrent tumors after prior resection, and in 1 patient GKS was used as an adjunct after subtotal resection. The median tumor volume at GKS was 2.75 cm3 (range 0.7–5.9 cm3). A median radiation dose of 14 Gy (range 11–20 Gy) was delivered to the tumor margin.

Results
The median follow-up duration was 73 months (range 42–90 months). Overall local tumor control was achieved in 4 tumors (67%) with progression-free periods of 24, 42, 57, and 66 months. Three tumors regressed and one remained unchanged. In 2 patients the tumors progressed, and in 1 of these patients the lesion was managed by repeated GKS with subsequent tumor regression. The other relatively large tumor (5.9 cm3) was excised 9 months after GKS. The progression-free period for all GKS-managed tumors varied from 9 to 66 months. There were no cases of hydrocephalus or GKS-related morbidity.

Conclusions
Gamma Knife surgery may be an additional minimally invasive management option for SEGA in a patient who harbors a small but progressively enlarging tumor when complete resection is not safely achievable. It may also benefit patients with a residual or recurrent tumor that has progressed after surgery.
La gestion spirituelle du VIH/sida : parcours biographique et construction identitaire
Authors: Bégot Anne-Cécile 
Published: October 2010

Spiritually coping with HIV/AIDS. Biographical portraits and building of the personality
Within the framework of a study of the Agence nationale de recherches sur le sida (ANRS), a survey has been fulfilled among HIV/AIDS infected people who are spiritually involved, the scope being to understand the role and the importance of the spirituality in the building of the personality of this people.
After explaining what is meant by « spiritually involved », we described three different types of spiritual journeys, relying on chosen portraits. They differ one from another because the link to religion has taken three different forms: inherited religion, religion as a cultural link, religious opposition.
Devenir mère dans le contexte des multithérapies antirétrovirales
Authors: Coulon Myriam , Feroni Isabelle 
Published: October 2010

Becoming mother in HAART context
This paper focuses on reproductive life course of HIV-infected women, in the context of HIV chronicisation. Twenty semi-structured in-depth interviews of HIV infected women of the French MANIF 2000 cohort were analysed to study the effects of a lower viral transmission risk during the second part of nineties on pregnancy decision making. Results show more pregnancies since 1996 and better doctor acceptance in relation with a good women health and compliance to an antiretroviral the- rapy. Reproductive behaviours normalisation is also related to the stop of drug addiction and stable relationships with the main partner.
Différenciation sexuelle des interprétations causales de la maladie en Afrique subsaharienne (Burkina Faso)
Authors: Egrot Marc 
Published: October 2010

Sexual differentiation and causal interprétation of illness in subsaharian Africa (Burkina Faso)
The social sex is implied in the construction and representation of several illnesses among the Mossis of Burkina Faso, especially those regarding sexuality (diseases transmitted during sexual intercourse), individual reproduction (sterility, impotence) and group reproduction (children diseases and witchcraft). Interferences between these categories may exist and imply an asymmetry between etiological models and imputation logics. They also represent opportunities to enhance the social norms associated to each gender and the risks generated by transgression. The illness is both a form of expression and a space of legitimation of the social differentiation between genders
Lutte contre le sida : reconfiguration d'une politique de « réduction des risques liés à l'usage de drogues » à Marseille
Authors: Le Naour Gwenola 
Published: October 2010

Fight against AIDS: the reshaping of a policy of «reduction of harm linked to drug using» in Marseilles
The writer focuses on the changes in Marseilles' s healthcare policy for drug-addicts during the 1990' s. Doing so, she evaluates the influence of the nationwide adoption of so-called policies of reduction of harms linked to drug-using (hence, harm reduction policy). The arrivai of AIDS and the decision to carry out health and social harm reduction policies linked to drug addiction thus bring to light people whose conceptions of the issue of drugs, of drug addiction, and of treatments to implement are in competition with those of «traditional» contributors to the issue of drug addiction. The emergence of these agents does not lead to the victory of one group over another but to juxtapositions and hybridisations of the various plans of action and public policies.
Soutien social et santé psychologique de victimes d'inondations
Authors: Maltais Danielle , Lachance Lise , Brassard Audrey , Dubois Mathieu 
Published: October 2010

Social support, coping and psychological health after a flood
Two years after serious flooding, a study was conducted involving 177 disaster victims. This article presents the results of analyses aiming to identify the principal factors associated with post-disaster psychological problems by examining mediating or moderating influences of social support and adjustment strategies in the stressor-health link. The results show, within the variables studied, that there are very few significant differences between men and women; however, women did receive more help for evacuation, cleaning, and rebuilding. The results also demonstrate that exposure to the stressor is the greatest contributor in explaining manifestations of post-traumatic stress, while variables like social support and adjustment strategies are more likely to explain the existence of depression symptoms and psychological stress. The analyses also allow conclusions to be drawn about mediating and moderating effects of adjustment strategies in the stressor-health link. In other respects, the observed effects involving social support variables are direct.
Introduire le changement dans les systèmes de soins au Québec : comment tirer profit de l'expérimentation sociale ?
Authors: Touati Nasséra , Denis Jean-Louis , Contandriopoulos André-Pierre , Béland François 
Published: October 2010

Introducing change in health care Systems from Quebec: how to benefit from social experimentation?
Based on an implementation analysis of an experimentation of a System of integrated care for frail elderly (in the province of Quebec, Canada), this paper initiates reflections about the introduction of reforms in health care Systems. It highlights the advantages of decentralized, participatory change stratégies, based on social experimentation. Theses strategies are particularly interesting in the case of complex changes, in which they in fact allow the autonomy necessary for learning. In conclusion, we propose some hypotheses concerning factors which make these social experimentations successful.
« On sait qu'il n'y a pas de "vrais" risques ». Discours et pratiques de soignants autour des infections nosocomiales
Authors: Amiel Céline 
Published: October 2010

« Se sabe que no hay "verdaderos" riesgos ».
Discursos y prácticas del personal sanitario
acerca de las infecciones nosocomiales
La higiene hospitalaria trata de luchar contra la transmisión de los agentes patógenos dentro de una estructura hospitalaria. Las prácticas de los médicos y de las enfermeras no corresponden siempre con las recomendaciones higiénicas. El enfoque antropológico permite recalcar las lógicas internas de los factores que impulsan los discursos y hechos de los profesionales de la salud. Muy présente en la realidad diaria de los médicos y de las enfermeras, la gestión de la higiene es muy a menudo sujeta a reinterpretaciones por parte de los médicos y de las enfermeras, según sus propios esquemas de pensamiento. La percepción del riesgo aparece entonces como el resultado de una percepción y de una opinion subjetivas de las situaciones a las que se enfrentan los profesionales de la salud.
Phylogeographic structure of jack pine (Pinus banksiana; Pinaceae) supports the existence of a coastal glacial refugium in northeastern North America
Authors: Godbout Julie , Beaulieu Jean , Bousquet Jean 
Published: October 2010

• Premise of the study: The genetic structure of jack pine (Pinus banksiana Lamb.), a North American boreal conifer with large longitudinal distribution, was investigated to test for the possible existence of a genetically distinct lineage in the Maritimes region in northeastern North America, which could be indicative of a mid‐latitude coastal refuge during the last glaciation.• Methods: One maternally inherited mitochondrial DNA (mtDNA) minisatellite marker and four paternally inherited chloroplast DNA (cpDNA) microsatellite markers were used to assess the range‐wide geographical structure of jack pine populations with particular focus on northeastern North America.• Key results: The populations from the Maritimes region presented a unique mtDNA background characterized by very low diversity and the preponderance of a distinctive mitotype. The distribution of cpDNA diversity was not spatially structured, though three chlorotypes were restricted to the east.• Conclusions: MtDNA data suggest that populations from the Maritimes region derive from a genetically depauperated north‐coastal refugium. Contrastingly, the much higher geographical uniformity observed for cpDNA variation indicates that gene flow by pollen had been much more effective than seed gene flow at homogenizing population structure.
Development of SSR markers from Citrus clementina (Rutaceae) BAC end sequences and interspecific transferability in Citrus
Authors: Ollitrault Frédérique , Terol Javier , Pina Jose Antonio , Navarro Luis , Talon Manuel , Ollitrault Patrick 
Published: October 2010

• Premise of the study: Microsatellite primers were developed from bacterial artificial chromosome (BAC) end sequences of Citrus clementina and their transferability and polymorphism tested in the genus Citrus for future anchorage of physical and genetic maps and comparative interspecific genetic mapping.• Methods and Results: Using PAGE and DNA silver staining, 79 primer pairs were selected for their transferability and polymorphism among 526 microsatellites mined in BES. A preliminary diversity study in Citrus was conducted with 18 of them, in C. reticulata, C. maxima, C. medica, C. sinensis, C. aurantium, C. paradisi, C. lemon, C. aurantifolia, and some papedas (wild citrus), using a capillary electrophoresis fragment analyzer. Intra‐ and interspecific polymorphism was observed, and heterozygous markers were identified for the different genotypes to be used for genetic mapping.• Conclusions: These results indicate the utility of the developed primers for comparative mapping studies and the integration of physical and genetic maps.
Patient and Physician Predictors of Peritoneal Dialysis Technique Failure: A Population Based, Retrospective Cohort Study
Authors: Chidambaram Mala , Bargman Joanne M. , Quinn Robert R. , Austin Peter C. , Hux Janet E. , Laupacis Andreas 
Published: October 2010

Background The use of peritoneal dialysis (PD) has been declining over the past decade in Canada, and high technique failure rates have been implicated. Studies have examined clinical risk factors for PD technique failure, but few studies have addressed sociodemographic factors driving technique failure. There are no studies examining the effect of physician factors on technique failure. Methods We conducted a retrospective cohort study using Ontario healthcare databases from 1 April 1995 to 31 March 2005 to examine the effects of patient sociodemographic and physician characteristics on PD technique failure. The primary outcome was time to technique failure. Secondary outcomes included the proportion of patients experiencing technique failure during the first year and the proportion of patients experiencing death during the study period. A competing risks analysis was applied to the Cox proportional hazards model to determine the predictors of technique failure, death, and kidney transplantation. Results In 5162 incident PD patients, the probability of technique success and patient survival at 5 years was 58.2% and 46.9% respectively. Of patients failing PD, 43.5% failed during the first year of treatment. Statistically significant predictors of technique failure included increasing age [hazard ratio (HR) 1.02], diabetes mellitus (HR 1.32), lower neighborhood education level (HR 2.93), and receiving transient (≤ 3 months) hemodialysis before starting PD (HR 1.24). Predictors of patient death included increasing age (HR 1.05), diabetes mellitus (HR 1.44), coronary artery disease (HR 1.26), congestive heart failure (HR 1.58), and late referral to the nephrologist (HR 1.27). Distance from treating dialysis center and residing in a rural area did not impact the risk of technique failure or death. Male physician gender increased the risk of technique failure (HR 1.31). Increased PD patient volume decreased the risk of technique failure (HR 0.98). None of the physician factors were predictors of patient death. Conclusion These findings support the need for implementing strategies to reduce technique failure, which could include increasing educational resources for patients initiating PD, aggressive risk factor modification in patients with multiple comorbidities, and increasing physician awareness regarding the detrimental outcomes associated with late referral and late PD start.
Pain-specific Beliefs and Pain Experience in Children with Juvenile Idiopathic Arthritis: A Longitudinal Study
Authors: THASTUM MIKAEL , HERLIN TROELS 
Published: October 2010

Objective.To assess longitudinal associations between pain-specific health beliefs and pain in children with juvenile idiopathic arthritis (JIA), and to compare a selected group of patients with high pain and low disease activity (high-pain patients) with the remaining group.Methods.Forty-seven children with JIA, aged 7–15 years, completed the children’s version of the Survey of Pain Attitudes (SOPA-C) and a 3-week pain diary at study entry (T1) and in a followup study 2 years later (T2). Parents also rated the Childhood Health Assessment Questionnaire (CHAQ), and an arthritis activity score was calculated each time. Second-order principal component analysis was conducted to reduce the number of independent variables. Regression analysis of the dependent measure was performed. The use of health beliefs was compared using t test for independent samples.Results.T1 health beliefs predicted 7% of the variance in T2 pain scores after controlling for T1 pain, CHAQ, and disease activity. At T2, statistical differences were found between the scores of the high-pain group and the rest of the group for the health belief subscales of disability (mean ± SD 2.7 ± 0.5 and 2.2 ± 0.7, respectively) and harm (mean ± SD 3.8 ± 0.8 and 3.3 ± 0.6).Conclusion.Our findings suggest that pain beliefs are influential on the longitudinal course of pain in children with JIA. Dysfunctional health beliefs in patients with high pain seem to be stable over time.