bluuebunny/crossref_metadata_2025_split huggingface dataset:
Public real estate returns and inflation shocks: The central role of inflation nonneutrality
Authors: Connolly Robert A. , Stivers Chris 
Published: June 2024

AbstractWe study the comovement of public real estate returns and inflation shocks over 1981–2022, using both survey‐based expected inflation and the Consumer Price Index (CPI). We find a complex relation that is: strongly negative during weaker‐economic (WE) times over the 1980s and 1990s, when stagflation was more a concern; strongly positive during WE times over roughly 2000–2022, when low growth with low inflation tended to be more a concern; and marginally negative otherwise. Linking inflation to both macroeconomic fundamentals and real estate operational data, we show that inflation shocks comove with changing beliefs about the underlying economic‐growth state and/or the risk premium. Thus, we argue that inflation nonneutrality has a central role in understanding our findings.
Price customization and targeting in matching markets
Authors: Gomes Renato , Pavan Alessandro 
Published: June 2024

AbstractWe introduce a model of (platform‐mediated) many‐to‐many matching in which agents' preferences are both vertically and horizontally differentiated. We first show how the model can be used to derive the profit‐maximizing matching plans under customized pricing. We then investigate the implications for targeting and welfare of uniform pricing (be it explicitly mandated or induced by privacy regulation), preventing the platform from conditioning prices on agents' profiles. The model can be applied to study ad exchanges, online retailing, and media markets.
Does the cross‐border e‐commerce comprehensive pilot zones policy affect the urban–rural income gap in China?
Authors: He Bing , Xu Da , Nan Guoqi , Zhang Xiaoyu , Yu Xiuxiu 
Published: June 2024

AbstractWith the development of Internet technology and modern supply chains, cross‐border e‐commerce (CBEC) has become one of the most important forms of international trade. The impact of this new mode of trade on economic growth and income disparity is worthy of further examination. This study treats the CBEC pilot zone policy as a quasi‐natural experiment, using the difference‐in‐differences approach to examine its impact on the urban–rural income gap. The findings showed that: (1) This policy significantly widened the urban–rural income gap; (2) innovation, entrepreneurship, and export are important paths toward expanding the impact of the CBEC pilot policy on the income gap, but the digital environment suppresses these expanding paths; and (3) the impact of this policy on the income gap shows distinct regional heterogeneity. This study provides several recommendations on how to promote balanced incomes.
Blending in or standing out? Gendered political communication in 24 democracies
Authors: Castanho Silva Bruno , Pullan Danielle , Wäckerle Jens 
Published: June 2024

AbstractWomen in male‐dominated organizations often must adopt more stereotypical masculine traits to advance within those hierarchies. While politics, historically male‐dominated, should induce women to blend in, increasing numbers of women in parliaments may give women the opportunity to stand out by not adopting a masculine style. This paper investigates how these contradictory incentives influence female Members of Parliament (MPs) in 24 democracies between 1987 and 2022, applying machine learning to 6.8 million parliamentary speeches to measure how feminine is their speaking style. Findings indicate a socialization effect, whereby women adopt a more masculine style the longer they stay in office, even after controlling for their speeches’ topics. The effect is strongest for women in socially progressive parties. This research highlights the role of parliaments as gendered workplaces, which still lead women to adapt to the male norm, and helps us understand the incentives that shape how women represent women in parliament.
A possible association between intraocular pressure changes and pigment epithelial detachment in central serous chorioretinopathy
Authors: Balaratnasingam Chandrakumar , Curcio Christine A. , Morgan William H. , van Dijk Elon H. C. 
Published: June 2024

AbstractCentral serous chorioretinopathy (CSC) is a frequently occurring chorioretinal disease, that is commonly associated with subretinal fluid accumulation in a generally young population. Even though choroidal abnormalities have been found to be of importance, the exact pathogenesis of CSC is still being learned. The origin of pigment epithelial detachments, seen in many CSC patients, is also unclear. Based on the follow‐up of a CSC patient for more than 5 years, we hypothesize that intraocular pressure and, by extension, the pressure gradient across the Bruch's membrane, may be one factor in the pathogenesis of pigment epithelial detachments in CSC, which might very well have implications for the occurrence of and possible ways to prevent subretinal fluid in CSC.
Changes in T‐cell subsets occur in interstitial lung disease and may contribute to pathology via complicated immune cascade
Authors: Karaselek Mehmet Ali , Duran Tugce , Kuccukturk Serkan , Vatansev Hulya , Oltulu Pembe 
Published: June 2024

The study aimed to investigate the expression profiles of transcription factors, cytokines, and co‐stimulatory molecules in helper T (Th)‐cell subsets within bronchoalveolar lavage (BAL) samples of patients with interstitial lung diseases (ILDs). Twenty ILDs patients were included in the study, comprising those with idiopathic pulmonary fibrosis (IPF) (n:8), autoimmune‐related ILDs (auto‐ILD) (n:4), and orphan diseases (O‐ILD) (n:8), alongside five control subjects. Flow cytometry was employed to evaluate the Th to cytotoxic T cell (CTL) ratio in BAL fluid, while cytopathological examination assessed macrophages, lymphocytes, and neutrophils. Quantitative real‐time polymerase chain reaction was utilized to investigate the expressions in Th1, Th2, Th17, and regulatory T (Treg) cells. Results revealed elevated Th cell to CTL ratios across all patient groups compared to controls. Furthermore, upregulation of Th1, Th2, Th17, and T‐cell factors was observed in all patient groups compared to controls. Interestingly, upregulation of CD28 and downregulation of CTLA‐4 and PD‐1 gene expression were consistent across all ILDs groups, highlighting potential immune dysregulation. This study provides a comprehensive exploration of molecular immunological mechanisms in ILDs patients, underscoring the dominance of Th2 and Th17 responses and revealing novel findings regarding the dysregulation of CD28, CTLA‐4, and PD‐1 expressions in ILDs for the first time.
Expanding the spectrum of phenotypes for MPDZ: Report of four unrelated families and review of the literature
Authors: Rad Aboulfazl , Bartsch Oliver , Bakhtiari Somayeh , Zhu Changlian , Xu Yiran , Monteiro Fabíola P. , Kok Fernando , Vulto‐van Silfhout Anneke T. , Kruer Michael C. , Bowl Michael R. , Vona Barbara 
Published: June 2024

AbstractMPDZ, a gene with diverse functions mediating cell–cell junction interactions, receptor signaling, and binding multivalent scaffold proteins, is associated with a spectrum of clinically heterogeneous phenotypes with biallelic perturbation. Despite its clinical relevance, the mechanistic underpinnings of these variants remain elusive, underscoring the need for extensive case series and functional investigations. In this study, we conducted a systematic review of cases in the literature through two electronic databases following the PRISMA guidelines. We selected nine studies, including 18 patients, with homozygous or compound heterozygous variants in MPDZ and added five patients from four unrelated families with novel MPDZ variants. To evaluate the role of Mpdz on hearing, we analyzed available auditory electrophysiology data from a knockout murine model (Mpdzem1(IMPC)J/em1(IMPC)J) generated by the International Mouse Phenotyping Consortium. Using exome and genome sequencing, we identified three families with compound heterozygous variants, and one family with a homozygous frameshift variant. MPDZ‐related disease is clinically heterogenous with hydrocephaly, vision impairment, hearing impairment and cardiovascular disease occurring most frequently. Additionally, we describe two unrelated patients with spasticity, expanding the phenotypic spectrum. Our murine analysis of the Mpdzem1(IMPC)J/em1(IMPC)J allele showed severe hearing impairment. Overall, we expand understanding of MPDZ‐related phenotypes and highlight hearing impairment and spasticity among the heterogeneous phenotypes.
Postoperative complications and emergency surgeries in colorectal cancer patients <50 years—a national cohort study
Authors: Gutlic Ida , Saraste Deborah , Nordenvall Caroline , Martling Anna , Lydrup Marie‐Louise , Buchwald Pamela 
Published: June 2024

AbstractAimThe incidence of colorectal cancer (CRC) in Sweden is increasing in individuals <50 years. This study aimed to examine differences in postoperative 30‐day complications and rate of emergency surgeries in CRC patients <50 years at diagnosis compared to older age groups since population‐based research on this topic is scarce.MethodThis population‐based study included data from the Swedish Colorectal Cancer Registry for patients undergoing CRC resection between 2010 and 2018. Bivariate analysis and logistic regression were used to analyse the relationship between age groups (<50, 50–79 and ≥80 years) and probability of postoperative 30‐day complications adjusted for gender, tumour localization, neoadjuvant (chemo)radiotherapy and American Society of Anesthesiologists score.ResultsIn total 33 320 patients were included. Patients <50 years had a lower American Society of Anesthesiologists score, more advanced tumours and received more neoadjuvant treatment. Emergency surgeries were less common in the youngest age group (P < 0.001) as well as overall postoperative 30‐day complications: ORadj 0.84 (95% CI 0.74–0.96) compared to those ≥80 years. Surgical complications were more common in age groups <50 and 50–79 years (16.5% and 16.9% respectively) compared to patients ≥80 years (14.1%) (P < 0.001). Anastomotic leakage and intra‐abdominal infections were more frequent in patients <50 years (5.7% and 3.5% respectively) compared to age groups 50–79 years (5.1% and 2.8% respectively) and ≥80 years (3.5% and 2.1% respectively) (P < 0.001). Wound infections were more common in the two youngest age groups compared to patients ≥80 years (5.3% vs. 3.7% respectively) (P < 0.001).ConclusionColorectal cancer patients <50 years and 50–79 years had a higher proportion of surgical complications regarding anastomotic leakage, intra‐abdominal infections and wound infections but lower overall postoperative complications. The incidence of surgical emergencies was highest amongst patients ≥80 years. Postoperative diagnostic workup in symptomatic individuals <50 years is warranted.
Rationale and design for a pragmatic randomized trial to assess gene‐based prescribing for SSRIs in the treatment of depression
Authors: Hines Lindsay J. , Wilke Russell A. , Myers Rachel , Mathews Carol A. , Liu Michelle , Baye Jordan F. , Petry Natasha , Cicali Emily J. , Duong Benjamin Q. , Elwood Erica , Hulvershorn Leslie , Nguyen Khoa , Ramos Michelle , Sadeghpour Azita , Wu R. Ryanne , Williamson Lloyda , Wiisanen Kristin , Voora Deepak , Singh Rajbir , Blake Kathryn V. , Murrough James W. , Volpi Simona , Ginsburg Geoffrey S. , Horowitz Carol R. , Orlando Lori , Chakraborty Hrishikesh , Dexter Paul , Johnson Julie A. , Skaar Todd C. , Cavallari Larisa H. , Van Driest Sara L. , Peterson Josh F. ,   the IGNITE Pragmatic Trials Network
Published: June 2024

AbstractSpecific selective serotonin reuptake inhibitors (SSRIs) metabolism is strongly influenced by two pharmacogenes, CYP2D6 and CYP2C19. However, the effectiveness of prospectively using pharmacogenetic variants to select or dose SSRIs for depression is uncertain in routine clinical practice. The objective of this prospective, multicenter, pragmatic randomized controlled trial is to determine the effectiveness of genotype‐guided selection and dosing of antidepressants on control of depression in participants who are 8 years or older with ≥3 months of depressive symptoms who require new or revised therapy. Those randomized to the intervention arm undergo pharmacogenetic testing at baseline and receive a pharmacy consult and/or automated clinical decision support intervention based on an actionable phenotype, while those randomized to the control arm have pharmacogenetic testing at the end of 6‐months. In both groups, depression and drug tolerability outcomes are assessed at baseline, 1 month, 3 months (primary), and 6 months. The primary end point is defined by change in Patient‐Reported Outcomes Measurement Information System (PROMIS) Depression score assessed at 3 months versus baseline. Secondary end points include change inpatient health questionnaire (PHQ‐8) measure of depression severity, remission rates defined by PROMIS score < 16, medication adherence, and medication side effects. The primary analysis will compare the PROMIS score difference between trial arms among those with an actionable CYP2D6 or CYP2C19 genetic result or a CYP2D6 drug–drug interaction. The trial has completed accrual of 1461 participants, of which 562 were found to have an actionable phenotype to date, and follow‐up will be complete in April of 2024.
Item Response Theory Models for Polytomous Multidimensional Forced‐Choice Items to Measure Construct Differentiation
Authors: Qiu Xuelan , de la Torre Jimmy , Wang You‐Gan , Wu Jinran 
Published: June 2024

AbstractMultidimensional forced‐choice (MFC) items have been found to be useful to reduce response biases in personality assessments. However, conventional scoring methods for the MFC items result in ipsative data, hindering the wider applications of the MFC format. In the last decade, a number of item response theory (IRT) models have been developed, majority of which are for MFC items with binary responses. However, MFC items with polytomous responses are more informative and have many applications. This paper develops a polytomous Rasch ipsative model (pRIM) that can deal with ipsative data and yield estimates that measure construct differentiation—a latent trait that describes the degree to which the personality constructs (e.g., interests) distinguish between each other. The pRIM and its simpler form are applied to a career interests assessment containing four‐category MFC items and the measures of interests differentiation are used for both intra‐ and interpersonal comparisons. Simulations are conducted to examine the recovery of the parameters under various conditions. The results show that the parameters of the pRIM can be well recovered, particularly when a complete linking design and a large sample are used. The implications and application of the pRIM in the personality assessment using MFC items are discussed.
‘Beyond the Scale’: A Qualitative Exploration of the Impact of Weight Stigma Experienced by Patients With Obesity in General Practice
Authors: Ryan Leona , Quigley Fiona , Birney Susie , Crotty Michael , Conlan Owen , Walsh Jane C. 
Published: June 2024

ABSTRACTObjectiveObesity is a complex, chronic, relapsing disease that requires an individualised approach to treatment. However, weight stigma (WS) experienced in healthcare settings poses a significant barrier to achieving person‐centred care for obesity. Understanding the experiences of people living with obesity (PwO) can inform interventions to reduce WS and optimise patient outcomes. This study explores how patients with obesity perceive WS in general practice settings; its impact on their psychological well‐being and health behaviours, and the patients suggestions for mitigating it.MethodsIn‐depth semistructured interviews were conducted with 11 PwO who had experienced WS in general practice settings in Ireland. The interviews were conducted online via Zoom between May and August 2023; interviews lasted between 31 and 63 min (M = 34.36 min). Interviews were audio‐recorded, transcribed verbatim and analysed using inductive reflexive thematic analysis.ResultsThree overarching themes specific to participants' experience of WS in general practice were generated: (1) shame, blame and ‘failure’; (2) eat less, move more—the go‐to treatment; (3) worthiness tied to compliance. A fourth theme: (4) the desire for a considered approach, outlines the participants' suggestions for reducing WS by improving the quality of patient–provider interactions in general practice.ConclusionThe findings call for a paradigm shift in the management of obesity in general practice: emphasising training for GPs in weight‐sensitive communication and promoting respectful, collaborative, and individualised care to reduce WS and improve outcomes for people with obesity.Patient or Public ContributionPPI collaborators played an active and equal role in shaping the research, contributing to the development of the research questions, refining the interview schedule, identifying key themes in the data, and granting final approval to the submitted and published version of the study.
Mismatch repair deficiency: how reliable is the two‐antibody approach? A national real‐life study
Authors: Vink‐Börger Elisa , den Bakker Michael , Voorham Rinus , van Nederveen Francien , Nagtegaal Iris 
Published: June 2024

AimsTraditionally, mismatch repair (MMR) status is determined by a panel of four antibodies (MLH1, PMS2, MSH2, MSH6). If all proteins are retained, cases are MMR proficient (pMMR), while loss of one or more proteins is indicative of MMR deficiency (dMMR). This approach has been challenged in favour of a two‐antibody approach, using PMS2 and MSH6 as a first screening. Their retainment is deemed sufficient to declare cases pMMR. In this study we aim to verify the validity of the two‐antibody approach.Methods and ResultsWe performed a nationwide study in colorectal cancer (CRC) and endometrial cancer (EC) diagnosed between 2016 and 2023, including 47,657 patients to evaluate the two‐antibody approach. In 0.17% and 0.4% of cases of CRC and EC, respectively, dMMR cases would be missed with the two‐antibody approach. Subgroup analyses pointed towards slightly increased miss rates in younger patients (under the age of 50 years) in both groups and identified special subtypes (signet ring cell carcinoma, medullary carcinoma, and mucinous carcinoma in CRC and clear cell carcinoma in EC) with increased miss rates. For these specific subgroups, a low threshold should be used for further testing. In case of ambiguous or heterogeneous staining patterns, four antibodies should be used.ConclusionIn general, the application of a two‐antibody MMR testing strategy does not lead to considerable failure of dMMR identification and saves costs.
Impact of air‐polishing with erythritol on exposed root dentin: A randomized clinical trial
Authors: Kruse Anne Brigitte , Burkhardt Ann‐Sophie , Vach Kirstin , Hellwig Elmar , Woelber Johan Peter , Schlueter Nadine , Ratka‐Krüger Petra 
Published: June 2024

AbstractIntroductionThe effects of air‐polishing on exposed root dentin surfaces are largely unknown, as there are only few studies which show heterogeneous results. Thus, this study was to investigate roughness changes of exposed dentin surfaces after air‐polishing and the influence of subsequent polishing with cup and paste.MethodsTotally 54 teeth with exposed root dentin surfaces were treated using a split‐mouth design by either air‐polishing with erythritol and a rubber cup with polishing paste on the test side, or rubber cup and paste alone. Teeth were finally cleaned using a sonic tooth brush. Impressions were taken at relevant time points and replicated using epoxy resin. The resulting casts were profilometrically analysed to obtain the average surface roughness (sRa) and maximum peak‐to‐valley height (sRz), which are given as the mean ± standard deviation in μm.ResultsAfter air‐polishing, in comparison to the baseline, there was a slight but significant increase in sRa (0.168 ± 0.143, p < 0.001), but sRz did not change (−0.471 ± 4.857, p = 0.936). Subsequent polishing with cup and paste and cleaning with a sonic toothbrush did not reduce the surface roughness (sonic toothbrush‐air‐polishing, sRa −0.044 ± 0.081, p = 0.218; sRz −0.551 ± 3.563, p = 0.903).ConclusionThe use of erythritol led to a slight increase in the roughness of the dentin surface, which was not reduced by polishing with a cup and paste. Polishing paste did not seem to conceal surface irregularities.
In vitro evaluation of surface roughness of titanium abutments after air polishing with different abrasive powders
Authors: Roberto Pedro Francisco Almeida , Luís Henrique Soares , Oliveira Sofia Arantes 
Published: June 2024

AbstractObjectivesThe purpose of this study was to evaluate the effects of air polishing with sodium bicarbonate and erythritol powders on surface roughness and morphological changes in titanium abutments.MethodsA total of 45 grade V titanium discs were divided in three groups: Group A (Control) air polished with air/water; Group B, air polished with sodium bicarbonate powder; and Group C, air polished with erythritol powder. After air polishing, the samples' roughness (Sa) in micrometres were analysed with an optical profilometer. The samples' surface morphology study was conducted via scanning electronic microscope (SEM). Data were described using mean and standard deviation of roughness values (Sa). Inferential analysis was performed using the ANOVA multiple comparison test followed by Tukey's post hoc test. Both tests used a 5% level of significance.ResultsAfter air polishing, average roughness of group A, B and C were 0.036, 0.046 and 0.037 μm, respectively, with statistically significant differences between groups A and B (p < 0.05). No statistically significant differences were found between group A and group C, as well as between group B and C (p > 0.05). As for the morphology analysis, damages to the titanium surface were only observed in group B.ConclusionsThe study indicates that air polishing with erythritol powder maintains titanium abutment integrity better than sodium bicarbonate, which increased surface roughness and caused damage. Erythritol is preferable for minimizing surface alterations and maintaining morphological stability.