bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel hybrid‐multiplexed fifteen‐switch converter with AC and DC outputs
Authors: Wang Jianfei , Wang Guifeng , Zhu Xinxin , Ma Yiming , Liu Zhan 
Published: May 2024

SummaryA novel hybrid‐multiplexed fifteen‐switch converter (HM‐15SC) topology, which can simultaneously output a set of three‐phase AC and three sets of DC, is proposed to address the problems of a single type of power electronic converter and the complexity of coordinated control of AC/DC hybrid systems for smart grid. In this paper, we conduct a detailed analysis of the topology and operating principles of HM‐15SC. This includes an examination of the converter's effective switching states in relation to output voltage, current paths, and maximum voltage stress. In addition, a modulation strategy combining single‐leg independent model prediction current control (SL‐MPCC) and time‐sharing cooperative (TSC) ideas is proposed to establish a single‐leg AC current prediction model, which effectively reduces the prediction arithmetic under the premise of realizing three‐leg independent prediction control and optimal control of AC/DC hybrid outputs. Finally, we verify the feasibility and superiority of the proposed HM‐15SC topology and its modulation strategy using the Typhoon HIL 402 platform.
The Photodynamic Antibacterial Activity Properties of a Series of Indium(III) Porphyrins and their Gold and Silver Nanoparticle Conjugates
Authors: Soy Rodah C. , Mafukidze Donovan , Mack John , Nyokong Tebello 
Published: May 2024

AbstractIn(III) tetraarylporphyrin complexes with 4‐thiomethylphenyl (1‐InPor), thien‐3‐yl (2‐InPor), thien‐2‐yl (3‐InPor) and 5‐bromothien‐2‐yl (4‐InPor) meso‐aryl rings have been synthesized and characterized. The complexes have been conjugated to gold and silver nanoparticles (AuNPs and AgNPs). The photodynamic antimicrobial chemotherapy (PACT) activities of 1–4‐InPor and their AuNP and AgNP conjugates have been investigated against both planktonic bacteria and biofilms of Gram‐(+) S. aureus and Gram‐(−) E. coli. 2.5 μg.mL−1 solutions of 1–4‐InPor exhibited favorable PACT activities against planktonic S. aureus with high Log10 reduction values in the 4.28–7.69 range upon 75 min photoirradiation with a Thorlabs M625L3 LED (240 mW.cm−2) mounted onto the illumination chamber of a Modulight 7710 medical laser system to provide a dose at the well‐plate of 86 mJ.cm−2.min−1. In contrast, low values in the 1.4–1.9 range were obtained against E. coli with 10 μg.mL−1 solutions. 1–4‐InPor exhibited relatively low PACT activity against the biofilm cells of S. aureus and E. coli. Conjugation of 1–4‐InPor to AgNPs and AuNPs significantly enhanced the PACT activities. This is demonstrated by the complete eradication of planktonic S. aureus at shorter irradiation times with high Log10 values>7.69 and moderate Log10 values>2 against planktonic E. coli for the meso‐thienylporphyrin conjugates.
Stepwise Construction of Multimetallic Complexes Supported by Heteroditopic NHC/MIC Ligands
Authors: Fonseca‐Olvera Josué G. , Ruiz‐Mendoza Francisco J. , Flores‐Ávila Amador , Meléndez‐Rodríguez Myriam , Suárez‐Castillo Oscar R. , Mendoza‐Espinosa Daniel 
Published: May 2024

AbstractWe report the stepwise synthesis of a novel series of heterometallic gold(I)/palladium(II) complexes supported by heteroditopic imidazol‐2‐ylidene/triazol‐5‐ylidene ligands. All new compounds were characterized by means of 1H and 13C NMR spectroscopy, melting points, and elemental analyses. The versatility of the ligand platforms, additionally allows for the preparation of cationic chelate biscarbenic palladium(II) complexes through full deprotonation of the mixed azolium precursors. Characterization studies were completed by the determination of the molecular structures of some synthetic intermediates. The new biscarbenic palladium(II) complexes were tested as catalysts in the cross‐coupling of boronic acid to a variety of chloroarenes and the hydrosilylation of terminal alkynes. Both catalytic processes provide good to excellent yields under low catalyst loadings.
Victim empowerment and satisfaction: The potential of imagery rescripting
Authors: Twardawski Mathias , Gollwitzer Mario , Altenmüller Marlene S. , Bertsch Katja , Lobbestael Jill , Philippi Antonia L. E. , Wittekind Charlotte E. 
Published: May 2024

AbstractImagery rescripting (ImRs) is a prominent approach to help individuals alleviate the negative consequences following victimization. In two studies (total N = 641), participants experienced a victimization incident induced by a video. In subsequent audio‐guided (ImRs or control) interventions, we examined the impact of imagined (i) victims' active or passive role, (ii) punishment for the offender (yes/no), and (iii) offender moral change (yes/no) on both psychological states and behavioural intentions. Specifically, after the ImRs, participants reported their feelings of empowerment, justice‐related satisfaction, positive and negative affect, and intention to act after the intervention. Results revealed that ImRs significantly reduced negative consequences of victimization, with active ImRs surpassing passive ImRs in enhancing victims’ empowerment and positive affect. Notably, neither imagined offender punishment nor moral change affected the efficacy of ImRs. We discuss these findings in light of ImRs as an intervention to address victims’ threatened needs.
Didymoplexiella siamensis (Gastrodieae, Orchidaceae), a new generic record for the flora of India
Authors: Khanal Madhusudhan , Sarkar Shuvadip , Dutta Rohit , Rai Santosh Kumar , Kumar Devendra , Rawat Sandeep , Agrawala Dinesh Kumar 
Published: May 2024

AbstractDidymoplexiella, a holomycotrophic terrestrial orchid genus has been reported for the first time in India. In India, the genus is represented by D. siamensis, and has been reported from Sikkim. Detailed morphology, supplemented with illustrative photoplates, along with information on habitat and phenology has been provided. Conservation assessment of D. siamensis has been done following IUCN guidelines.
Effects of throughflow and internal heating in a composite air‐porous medium
Authors: Gangadgaraiah Yeliyur Honnappa 
Published: May 2024

AbstractThe effect of an internal heat source linearly dependent on the solid fraction on the onset of convection in a composite air‐porous channel with vertical throughflow has been analyzed. We considered boundaries to be insulating to temperature perturbations. The governing equation that satisfies the air‐porous configuration is analyzed by the normal mode approach, solved by the regular perturbation technique for linear stability, and the critical internal Darcy–Rayleigh number for the onset of stationary convection has been derived. The paper aims to analyze the effects of parameters like heat source size, depth ratio, Darcy number, throughflow direction, solid fraction, and Prandtl number on stationary convection in a composite air‐porous configuration. Understanding these influences can illuminate thermal behaviors in intricate systems and inform applications in heat transfer and fluid dynamics. The observed stability configuration decreases monotonically due to increasing the effect of the depth ratio and solid fraction at any direction and velocity of the throughflow. The thermal and vertical velocity profiles and the results obtained during the analysis have been presented graphically.
Low‐intensity continuous ultrasound effect on proliferation and morphology of fibroblast cells
Authors: Tran Vo Tu Minh , Guangorena Zarzosa Guillermo Ignacio , Nakajima Keita , Kobayashi Takaomi 
Published: May 2024

AbstractRecently, the use of ultrasound (US) for triggering drug release to specific tissues was explored, but its direct effects on cells have not been thoroughly understood. For this reason, this study aimed to investigate the impact of US powers and US irradiation times on fibroblast cells (NIH‐3T3). The results showed that the diverse US settings had varying effects on cell proliferation and distribution in the polystyrene culture dish. Interestingly, at 10 W, 43 kHz with changing exposed time up to 30 min either stimulated or inhibited fibroblast cell growth after 24 and 72 h of cultivation compared to the control sample in the absence of US, while longer US exposure time led to a moderate reduction in cell quantity. Moreover, higher US levels of 20 and 30 W could cause an aggregation of cells and sublethal damage to the cells. Importantly, the morphology of fibroblast was changed from stellate‐shape to round‐shape under greater US powers. Elevated US power also influenced interactions between proteins and lipids, affecting the atomic and molecular charges, leading to changes in both zeta potential and pH of the dispensed cell solution.
Enhancing word signing in hearing students with reading disorders using computer‐based learning trials
Authors: Evans Sara , Skinner Christopher H. , Wolbers Kimberly , Mee Bell Sherry , Shahan Cheryl 
Published: May 2024

AbstractMultiple‐baseline‐across‐word‐sets designs were used to determine whether a computer‐based intervention would enhance accurate word signing with four participants. Each participant was a hearing college student with reading disorders. Learning trials included 3 s to observe printed words on the screen and a video model performing the sign twice (i.e., simultaneous prompting), 3 s to make the sign, 3 s to observe the same clip, and 3 s to make the sign again. For each participant and word set, no words were accurately signed during baseline. After the intervention, all four participants increased their accurate word signing across all three word sets, providing 12 demonstrations of experimental control. For each participant, accurate word signing was maintained. Application of efficient, technology‐based, simultaneous prompting interventions for enhancing American Sign Language learning and future research designed to investigate causal mechanisms and optimize intervention effects are discussed.
An in vitro feasibility study of 355 nm laser atherectomy for the treatment of peripheral atherosclerotic lesions
Authors: Wang Hui , Zuo Hui , Pan Dikang , Cao Yihui , Zhang Yiqun , Liu Duan , Guo Lianrui , Guo Jianming 
Published: May 2024

AbstractIn this study, we utilized a novel 355 nm laser to ablate porcine aortas in the presence of physiological saline and contrast agent. Subsequently, we investigated the shape and depth of the resulting injuries. After ablating bovine tendons and aortas with the laser, we analyzed the size and quantity of particles postablation. Finally, we conducted ablation experiments using human ex vivo plaques. The analysis revealed minimal damage to porcine aortas within 2 s of exposure to the 355 nm laser. The degree of injury in the presence of contrast agent was higher than that in the presence of physiological saline but significantly lower than the damage caused by 308 nm laser. Regardless of whether it was bovine tendon or porcine aorta tissue, the proportion of particles <25 μm postlaser ablation exceeded 99%. Lastly, the 355 nm laser successfully opened three types of plaques: chronically occluded, stent restenosis, and stale thrombosis.
Computational assessment of the use of graphene‐based nanosheets as PtII chemotherapeutics delivery systems
Authors: Belletto Daniele , Vigna Vincenzo , Barretta Pierraffaele , Ponte Fortuna , Mazzone Gloria , Scoditti Stefano , Sicilia Emilia 
Published: May 2024

AbstractGraphene is the newest form of elemental carbon and it is becoming rapidly a potential candidate in the framework of nano‐bio research. Many reports confirm the successful use of graphene‐based materials as carriers of anticancer drugs having relatively high loading capacities compared with other nanocarriers. Here, the outcomes of a systematic study of the adsorption behavior of FDA approved PtII drugs cisplatin, oxaliplatin, and carboplatin on surface models of pristine, holey, and nitrogen‐doped holey graphene are reported. DFT investigations in water solvent have been carried out considering several initial orientations of the drugs with respect to the surfaces. Adsorption free energies, calculated including basis set superposition error (BSSE) corrections, result to be significantly negative for many of the drug@carrier adducts indicating that tested layers could be used as potential carriers for the delivery of anticancer PtII drugs. The reduced density gradient (RDG) analysis allows to show that many kinds of non‐covalent interactions, including canonical H‐bond, are responsible for the stabilization of the formed adducts.
Skeletal muscle hypertrophy rewires glucose metabolism: An experimental investigation and systematic review
Authors: Baumert Philipp , Mäntyselkä Sakari , Schönfelder Martin , Heiber Marie , Jacobs Mika Jos , Swaminathan Anandini , Minderis Petras , Dirmontas Mantas , Kleigrewe Karin , Meng Chen , Gigl Michael , Ahmetov Ildus I. , Venckunas Tomas , Degens Hans , Ratkevicius Aivaras , Hulmi Juha J. , Wackerhage Henning 
Published: May 2024

AbstractBackgroundProliferating cancer cells shift their metabolism towards glycolysis, even in the presence of oxygen, to especially generate glycolytic intermediates as substrates for anabolic reactions. We hypothesize that a similar metabolic remodelling occurs during skeletal muscle hypertrophy.MethodsWe used mass spectrometry in hypertrophying C2C12 myotubes in vitro and plantaris mouse muscle in vivo and assessed metabolomic changes and the incorporation of the [U‐13C6]glucose tracer. We performed enzyme inhibition of the key serine synthesis pathway enzyme phosphoglycerate dehydrogenase (Phgdh) for further mechanistic analysis and conducted a systematic review to align any changes in metabolomics during muscle growth with published findings. Finally, the UK Biobank was used to link the findings to population level.ResultsThe metabolomics analysis in myotubes revealed insulin‐like growth factor‐1 (IGF‐1)‐induced altered metabolite concentrations in anabolic pathways such as pentose phosphate (ribose‐5‐phosphate/ribulose‐5‐phosphate: +40%; P = 0.01) and serine synthesis pathway (serine: −36.8%; P = 0.009). Like the hypertrophy stimulation with IGF‐1 in myotubes in vitro, the concentration of the dipeptide l‐carnosine was decreased by 26.6% (P = 0.001) during skeletal muscle growth in vivo. However, phosphorylated sugar (glucose‐6‐phosphate, fructose‐6‐phosphate or glucose‐1‐phosphate) decreased by 32.2% (P = 0.004) in the overloaded muscle in vivo while increasing in the IGF‐1‐stimulated myotubes in vitro. The systematic review revealed that 10 metabolites linked to muscle hypertrophy were directly associated with glycolysis and its interconnected anabolic pathways. We demonstrated that labelled carbon from [U‐13C6]glucose is increasingly incorporated by ~13% (P = 0.001) into the non‐essential amino acids in hypertrophying myotubes, which is accompanied by an increased depletion of media serine (P = 0.006). The inhibition of Phgdh suppressed muscle protein synthesis in growing myotubes by 58.1% (P < 0.001), highlighting the importance of the serine synthesis pathway for maintaining muscle size. Utilizing data from the UK Biobank (n = 450 243), we then discerned genetic variations linked to the serine synthesis pathway (PHGDH and PSPH) and to its downstream enzyme (SHMT1), revealing their association with appendicular lean mass in humans (P < 5.0e‐8).ConclusionsUnderstanding the mechanisms that regulate skeletal muscle mass will help in developing effective treatments for muscle weakness. Our results provide evidence for the metabolic rewiring of glycolytic intermediates into anabolic pathways during muscle growth, such as in serine synthesis.
A more accurate view of the Flat Wall Theorem
Authors: Sau Ignasi , Stamoulis Giannos , Thilikos Dimitrios M. 
Published: May 2024

AbstractWe introduce a supporting combinatorial framework for the Flat Wall Theorem. In particular, we suggest two variants of the theorem and we introduce a new, more versatile, concept of wall homogeneity as well as the notion of regularity in flat walls. All proposed concepts and results aim at facilitating the use of the irrelevant vertex technique in future algorithmic applications.
Synthesis of various 1‐alkylbenzimidazole derivatives directly from 2‐alkylaminonitroarenes via a two‐step, one‐pot procedure
Authors: Walewska‐Królikiewicz Magdalena , Wilk Bogdan , Kwast Andrzej , Wróbel Zbigniew 
Published: May 2024

AbstractN‐Alkyl‐2‐nitroanilines deoxygenated with tributylphosphine form intermediate 2‐(alkylamino)aryliminophosphoranes, which were subjected, without isolation, to various cyclocondensation reactions with CS2, CO2, alkyl isocyanates, acyl chlorides, anhydrides, or esters. A simple, convenient, one‐pot procedure provided derivatives of unsymmetrically substituted 1‐alkylbenzimidazoles functionalized at C2 in good to excellent yields. The method does not require the use of metals, sensitive catalysts, or pressure.
Clinical pharmacology considerations for first‐in‐human clinical trials for enzyme replacement therapy
Authors: Stern Sydney , Wang Jie , Li Ruo‐Jing , Hon Yuen Yi , Weis Shawna L. , Wang Yow‐Ming C. , Schuck Robert , Pacanowski Michael 
Published: May 2024

AbstractInborn errors of metabolism (IEM) such as lysosomal storage disorders (LSDs) are conditions caused by deficiency of one or more key enzymes, cofactors, or transporters involved in a specific metabolic pathway. Enzyme replacement therapy (ERT) provides an exogenous source of the affected enzyme and is one of the most effective treatment options for IEMs. In this paper, we review the first‐in‐human (FIH) protocols for ERT drug development programs supporting 20 Biologic License Applications (BLA) approved by the Center for Drug Evaluation and Research (CDER) at the US Food and Drug Administration (FDA) in the period of May 1994 to September 2023. We surveyed study design elements across these FIH protocols including study population, dosage form, dose selection, treatment duration, immunogenicity, biomarkers, and study follow‐up. A total of 18 FIH trials from 20 BLAs were identified and of those, 72% (13/18) used single ascending dose (SAD) and/or multiple ascending dose (MAD) study design, 83% (15/18) had a primary objective of assessing the safety and tolerability, 72% (13/18) included clinical endpoint assessments, and 94% (17/18) included biomarker assessments as secondary or exploratory endpoints. Notably, the majority of ERT products tested the approved route of administration and the approved dose was tested in 83% (15/18) of FIH trials. At last, we offer considerations for the design of FIH studies.
Recurrent episodes of atrioventricular nodal reentrant tachycardia: Sites of ablation success, ablation endpoint, and primary culprits for recurrence
Authors: Hirata Shu , Nagashima Koichi , Kaneko Yoshiaki , Tamura Shuntaro , Mori Hitoshi , Nishiuchi Suguru , Tokuda Michifumi , Kawaji Tetsuma , Hayashi Tatsuya , Nishimura Takuro , Fukunaga Masato , Kishihara Jun , Fukaya Hidehira , Teranishi Jin , Takami Mitsuru , Okada Masato , Miyazaki Naoko , Watanabe Ryuta , Wakamatsu Yuji , Okumura Yasuo 
Published: May 2024

AbstractBackgroundAtrioventricular nodal reentrant tachycardia (AVNRT) sometimes recurs even after anatomical slow pathway (SP) ablation targeting the rightward inferior extension (RIE). This multicenter study aimed to determine the reasons for AVNRT recurrence.Methods and ResultsForty‐six patients were treated successfully for recurrent AVNRT. Initial treatment was for 38 slow‐fast AVNRTs, 3 fast‐slow AVNRTs, 2 slow‐slow AVNRTs, 2 slow‐fast and fast‐slow AVNRTs, and 1 noninducible AVNRT. All initial treatments were of RF application to the RIE; SP elimination was achieved in 11, dual AVN physiology was seen in 29, and AVNRT remained inducible in 5. The recurrent AVNRTs included 34 slow‐fast AVNRTs, 6 fast‐slow AVNRTs, 3 slow‐slow AVNRTs, 2 slow‐fast and fast‐slow AVNRTs, and 1 slow‐fast and slow‐slow AVNRTs. Successful ablation site was within the RIE in 39 and left inferior extension in 7. In 30 of 39, the successful RIE site was in the same area or higher than that of the initial procedure.ConclusionFor a high majority (around 85%) of patients in whom AVNRT recurs after initial ablation success, the site of a second successful procedure will be within the RIE even though the RIE was originally targeted. Furthermore, a high majority (around 86%) of sites of successful ablation will be higher than those originally targeted.
Reducing resolution loss in naked‐eye 3D display using dual ferroelectric liquid crystal shutters for time‐multiplexed light‐field display
Authors: Sun Zhi‐Bo , Yuan Zheng‐Nan , Huo Yi‐Peng , Dong Shou‐Cheng , Cheung Alex Y. L. , Vashchenko Valerii , Vashchenko Olena , Srivastava Abhishek , Kwok Hoi‐Sing 
Published: May 2024

AbstractUsually, the resolution loss is severe in light‐field display due to the spatial multiplexing of several neighboring pixels to display images from different directions. However, limited by the resolution of the flat panel display, the light‐field 3D display shows insufficient display size, 3D image depth, or resolution. This article uses optimized ferroelectric liquid crystal (FLC) shutters with high contrast (~1000:1), ultra‐fast response (<20 μs), and polarity‐related binary switching at low operating voltage (5 V). This article utilized 32 time‐sequentially opened FLC light valve arrays refreshed at 2 kHz to display images from different directions. Because of the polarity‐sensitive switching nature of FLC, the reverse phase induces serious crosstalk between different images. This work uses the timing synchronization method of dual‐FLC liquid crystal cells to achieve independent control of 32 light valves without reverse phase, reducing the crosstalk and increasing the equivalent 3D resolution by multiplexing the flat panel display 32 times within 60 Hz.
Incidental pigmented basal cell carcinoma discovered on positron emission tomography (PET)
Authors: Jazaeri Yasaman , Del Marmol Véronique , Suppa Mariano , Dumarey Nicolas 
Published: May 2024

AbstractBasal cell carcinoma (BCC), which frequently occurs in sun‐exposed areas of the head and neck region, is the most common cutaneous malignancy but the least studied with radiologic imaging techniques. This article outlines the case of a 65‐year‐old male with a pigmented BCC of the right shoulder discovered on positron emission tomography‐computed tomography (PET/CT). The lesion was initially suspected as a melanoma. However, the histopathological features showed a tumor of basaloid cells. PET/CT is an excellent technique for the detection of hypermetabolic tumors, such as melanoma, squamous cell and Merkel cell carcinomas, in lymph nodes and distant organs. The usefulness of PET is limited for slowly growing tumors, such as BCC. However, PET/CT can be useful for the detection of distant metastasis in locally advanced BCC as well as in the follow‐up of locally advanced BCC on Hedgehog inhibitors.