bluuebunny/crossref_metadata_2025_split huggingface dataset:
Love Hurts (in More Ways Than One): Specificity of Psychological Symptoms as Predictors and Consequences of Romantic Activity Among Early Adolescent Girls
Authors: Starr Lisa R. , Davila Joanne , Stroud Catherine B. , Clara Li Po Ching , Yoneda Athena , Hershenberg Rachel , Ramsay Miller Melissa 
Published: February 2012

ObjectiveResearch has linked adolescent romantic and sexual activities to depressive symptoms. The current study examines whether such activities are uniquely linked to depressive symptoms versus symptoms of other disorders (including anxiety, externalizing, and eating disorders), and whether co‐occurring symptoms more precisely account for the association between depressive symptoms and romantic involvement.MethodEarly adolescent girls (N = 83; mean age = 13.45) participated in baseline and 1‐year follow up data collection.ResultsRomantic (i.e., dating and sexual) activities were longitudinally related to numerous types of symptoms. The association between depressive symptoms and romantic variables remained when considering co‐occurring symptoms. Girls with more comorbid disorders reported more romantic activities.ConclusionsResults suggest that the maladaptive consequences and precipitants of adolescent romantic activities extend beyond depression, but also imply that this association is not secondary to comorbid symptoms. Future work should clarify causal pathways.
Student Ratings of Selection Factors for PsyD Programs
Authors: Dornfeld Mitchell D. , Green-Hennessy Sharon , Lating Jeffrey , Kirkhart Matthew 
Published: February 2012

ObjectivesTo explore which factors doctor of psychology (PsyD) students feel are important to consider when selecting a PsyD program.DesignThis article analyzes the survey responses of 394 enrolled PsyD students and 17 directors of clinical training (DCTs), in which the respondents rated the importance of 18 factors in program selection to understand what qualities PsyD students and DCTs value in a PsyD program. Students were also asked to assess how their program fared on the same 18 dimensions.ResultsResults indicated that participants rated the program's structure, tone, and reputed quality of training as the most important factors in program selection (M's of 4.13 to 4.54 on a 5‐point scale). Additionally, students rated their current program as high in quality on the same factors that they felt were most important in program selection (r's ranging from .15 to .37).ConclusionsPsyD students rated a program's structure, tone, and reputation as particularly important factors to consider in selecting a program. Students' quality ratings were used to determine the top 5 programs for each of the factors assessed in the study.
Appearing Anxious Leads to Negative Judgments by Others
Authors: Gee Bethany A. , Antony Martin M. , Koerner Naomi , Aiken Audrey 
Published: February 2012

ObjectivesTo investigate people's perceptions of anxiety symptoms and the disclosure of anxiety by others, and how one's own level of social anxiety affects these perceptions.DesignUndergraduate students and community members high (n = 83) and low (n = 80) in social anxiety, as measured by the Social Interaction Anxiety Scale (SIAS; Mattick & Clark, 1998), were randomly assigned to watch 1 of 4 videos in which the target individual either appeared or did not appear anxious, and either disclosed or did not disclose her anxiety. Participants rated the target individual on various characteristics on which socially anxious individuals often fear being judged, and completed measures of their own level of social anxiety, perceived similarity to the target individual, and reasons for their ratings.ResultsParticipants negatively evaluated others who looked anxious on qualities related to awkwardness, social skills, and weakness, and the disclosure of anxiety was associated with fewer negative judgments. Participants’ own levels of social anxiety were not related to their judgments.ConclusionsThis study provided evidence that the concerns held by socially anxious individuals that others will judge them negatively based on their signs of anxiety is accurate to a degree. These findings might inform the process of cognitive restructuring for social anxiety.
Naturalistic Changes in Subjective Distress Outside of Therapy
Authors: Swift Joshua K. , Callahan Jennifer L. , Herbert Gregory L. , Heath Christopher J. 
Published: February 2012

ObjectivesTo establish the effectiveness or efficacy of psychological interventions, it is important to understand the nature of changes that occur in the absence of therapy.DesignIn this study, clinically distressed college students from 2 universities (n = 228) completed the Outcome Questionnaire (OQ)‐45.2 on a weekly basis throughout a single semester.ResultsAlthough 56.6% of the sample made no change or deteriorated, 43.4% made a reliable improvement. Change status was predicted by previous therapy experience and length of study participation. Multilevel growth modeling also indicated that participants’ OQ‐45.2 scores decreased over time (following a cubic trend) and the amount of decrease was associated with Time 1 OQ‐45.2 scores.ConclusionsLimitations of the study and further implications for treatment outcome research are discussed.
Depression and Anxiety Among Coronary Heart Disease Patients: Can Affect Dimensions and Theory Inform Diagnostic Disorder‐Based Screening?
Authors: Tully Phillip J. , Penninx Brenda W. 
Published: February 2012

ObjectivesTo examine the association between low positive affect, somatic anxiety and general distress with affective disorders, anxious misery, and visceral fear among coronary heart disease patients.ParticipantsPatients awaiting a coronary revascularization procedure (N = 158; 20.9% female; median age = 65, interquartile range 58–73) underwent structured interview with the Mini‐International Neuropsychiatric Interview. Patients completed a brief version of the Mood and Anxiety Symptom Questionnaire (i.e., Anxiety Depression Distress Inventory‐27) and a measure of Type D personality.ResultsSomatic anxiety scores yielded an area under the curve (AUC) = .784 and 75.0% sensitivity and 68.5% specificity in relation to panic disorder. Low positive affect yielded AUC = .811 and 70.4% sensitivity and 77.1% specificity for major depression. General distress yielded AUC = .795 and 75.0% sensitivity and 72.5% specificity for generalized anxiety disorder. No affective dimension was optimally associated with the anxious misery or visceral fear cluster. Trait negative affect was not a suitable screener for any disorder.ConclusionsThe Anxiety Depression Distress Inventory‐27 dimensions of low positive affect and somatic anxiety provided optimal detection of depression and panic disorder, respectively, as hypothesized, supporting discriminant validity.
PI3K‐independent AKT activation in cancers: A treasure trove for novel therapeutics
Authors: Mahajan Kiran , Mahajan Nupam P. 
Published: February 2012

AbstractAKT/PKB serine threonine kinase, a critical signaling molecule promoting cell growth and survival pathways, is frequently dysregulated in many cancers. Although phosphatidylinositol‐3‐OH kinase (PI3K), a lipid kinase, is well characterized as a major regulator of AKT activation in response to a variety of ligands, recent studies highlight a diverse group of tyrosine (Ack1/TNK2, Src, PTK6) and serine/threonine (TBK1, IKBKE, DNAPKcs) kinases that activate AKT directly to promote its pro‐proliferative signaling functions. While some of these alternate AKT activating kinases respond to growth factors, others respond to inflammatory and genotoxic stimuli. A common theme emerging from these studies is that aberrant or hyperactivation of these alternate kinases is often associated with malignancy. Consequently, evaluating the use of small molecular inhibitors against these alternate AKT activating kinases at earlier stages of cancer therapy may overcome the pressing problem of drug resistance surfacing especially in patients treated with PI3K inhibitors. J. Cell. Physiol. 227: 3178–3184, 2012. © 2012 Wiley Periodicals, Inc.
CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells
Authors: Sakuma Tomomi , Nakamoto Tetsuya , Hemmi Hiroaki , Kitazawa Sohei , Kitazawa Riko , Notomi Takuya , Hayata Tadayoshi , Ezura Yoichi , Amagasa Teruo , Noda Masaki 
Published: February 2012

AbstractTumor metastasis to bone is a serious pathological situation that causes severe pain, and deterioration in locomoter function. However, the mechanisms underlying tumor metastasis is still incompletely understood. CIZ/NMP4 is a nucleocytoplasmic shuttling protein and its roles in tumor cells have not been known. We, therefore, hypothesized the role of CIZ/NMP4 in B16 melanoma cells that metastasize to bone. CIZ/NMP4 is expressed in B16 cells. The CIZ/NMP4 expression levels are correlated to the metastatic activity in divergent types of melanoma cells. Overexpression of CIZ/NMP4 increased B16 cell migration in Trans‐well assay. Conversely, siRNA‐based knockdown of CIZ/NMP4 suppressed migratory activity of these cells. As RANKL promotes metastasis of tumor cells in bone, we tested its effect on CIZ in melanoma cells. RANKL treatment enhanced CIZ/NMP4 expression. This increase of CIZ by RANKL promoted migration. Conversely, we identified CIZ/NMP4 binding site in the promoter of RANKL. Furthermore, luciferase assay indicated that CIZ/NMP4 overexpression enhanced RANKL promoter activities, revealing a positive feedback loop of CIZ/NMP4 and RANKL in melanoma. These observations indicate that CIZ/NMP4 is critical regulator of metastasis of melanoma cells. J. Cell. Physiol. 227: 2807–2812, 2012. © 2012 Wiley Periodicals, Inc.
Gadd45a and Gadd45b modulate innate immune functions of granulocytes and macrophages by differential regulation of p38 and JNK signaling
Authors: Salerno Dominic M. , Tront Jennifer S. , Hoffman Barbara , Liebermann Dan A. 
Published: February 2012

AbstractGadd45 proteins function as stress sensors in response to various physiological and environmental stressors, interacting with other cellular proteins implicated in cellular stress responses, including p38 and JNK. This study shows that mice lacking either Gadd45a or Gadd45b are defective in the recruitment of granulocytes and macrophages to the intra‐peritoneal cavity following intra‐peritoneal administration of the bacterial cell wall pathogen‐associated molecular pattern lipopolysaccharide (LPS). Bone marrow derived granulocytes and macrophages lacking either Gadd45a or Gadd45b are shown to be impaired in their chemotactic response to LPS, as well as other inflammatory stimuli such as N‐formyl‐methionine–leucine–phenylalanine and IL‐8. Evidence was obtained also implicating Gadd45a and Gadd45b in other myeloid innate immune functions, including reactive oxygen species production, phagocytosis, and adhesion. Gadd45a and Gadd45b activation of p38 kinase was implicated in the response of granulocytes to LPS mediated chemotaxis, whereas Gadd45a and Gadd45b curtailment of JNK activation was linked to chemotaxis of macrophages in response to LPS. Collectively, these data highlight a novel role for both Gadd45a and Gadd45b in myeloid innate immune functions by differential modulation of p38 and JNK signaling in granulocytes compared to macrophages. J. Cell. Physiol. 227: 3613–3620, 2012. © 2012 Wiley Periodicals, Inc.
Biofiltration of a styrene/acetone vapor mixture in two reactor types under conditions of acetone overloading
Authors: Paca Jan , Halecky Martin , Novak Vratislav , Jones Kim , Kozliak Evguenii 
Published: February 2012

AbstractBACKGROUND: Evaluation of the biodegradation interactions between styrene and acetone, two typical paint solvents and vapor phase pollutants differing in water solubility and biodegradability, was conducted both in a trickle bed reactor (TBR) and a biofilter (BF). The loading rate experiments were performed by increasing the acetone concentration in the inlet air while keeping the styrene concentration and loading rate constant.RESULTS: At acetone loading rates (OLAC) between 25 and 35 gc m−3 h−1, the BF featured greater steady state performance characteristics for styrene degradation. At OLAC between 35 and 48 gc m−3 h−1, a decline of removal efficiency (RE) was observed for both pollutants, due to the system's overloading with acetone. Increasing OLAC above 52‐55 gc m−3 h−1 in both reactors resulted in drifts of RE and EC over time to much lower values. A step‐drop of acetone loading rate back to OLAC of 3 gc m−3 h−1 (gc denotes grams of carbon) resulted in lag periods lasting for several hours.CONCLUSIONS: Two important issues inherent for acetone biofiltration, e.g., from paint booths or polystyrene production, were identified: (1) poor performance at high loadings of this aggressive solvent and (2) acetone back‐stripping into the air following periods of high overloading. Copyright © 2012 Society of Chemical Industry
Rapid, effective, and long‐lasting behavioral recovery produced by microsutures, methylene blue, and polyethylene glycol after completely cutting rat sciatic nerves
Authors: Bittner G.D. , Keating C.P. , Kane J.R. , Britt J.M. , Spaeth C.S. , Fan J.D. , Zuzek A. , Wilcott R.W. , Thayer W.P. , Winograd J.M. , Gonzalez‐Lima F. , Schallert T. 
Published: February 2012

AbstractBehavioral function lost in mammals (including humans) after peripheral nerve severance is slowly (weeks to years) and often poorly restored by 1–2‐mm/day, nonspecifically directed outgrowths from proximal axonal stumps. To survive, proximal stumps must quickly repair (seal) plasmalemmal damage. We report that, after complete cut‐ or crush‐severance of rat sciatic nerves, morphological continuity, action potential conduction, and behavioral functions can be consistently (>98% of trials), rapidly (minutes to days), dramatically (70–85% recovery), and chronically restored and some Wallerian degeneration prevented. We assess axoplasmic and axolemmal continuity by intra‐axonal dye diffusion and action potential conduction across the lesion site and amount of behavioral recovery by Sciatic Functional Index and Foot Fault tests. We apply well‐specified sequences of solutions containing FDA‐approved chemicals. First, severed axonal ends are opened and resealing is prevented by hypotonic Ca2+‐free saline containing antioxidants (especially methylene blue) that inhibit plasmalemmal sealing in sciatic nerves in vivo, ex vivo, and in rat B104 hippocampal cells in vitro. Second, a hypotonic solution of polyethylene glycol (PEG) is applied to open closely apposed (by microsutures, if cut) axonal ends to induce their membranes to flow rapidly into each other (PEG‐fusion), consistent with data showing that PEG rapidly seals (PEG‐seals) transected neurites of B104 cells, independently of any known endogenous sealing mechanism. Third, Ca2+‐containing isotonic saline is applied to induce sealing of any remaining plasmalemmal holes by Ca2+‐induced accumulation and fusion of vesicles. These and other data suggest that PEG‐sealing is neuroprotective, and our PEG‐fusion protocols that repair cut‐ and crush‐severed rat nerves might rapidly translate to clinical procedures. © 2012 Wiley Periodicals, Inc.
To reflect or not to reflect: Prior team performance as a boundary condition of the effects of reflexivity on learning and final team performance
Authors: Schippers Michaéla C. , Homan Astrid C. , van Knippenberg Daan 
Published: February 2012

SummaryA small but growing body of literature adds to our understanding of the role of team reflexivity (i.e., reflecting upon team functioning) in predicting team performance. Although many studies conclude that reflexivity is an asset for teams, the contingencies of team reflexivity have received far less research attention. In this respect, we argue that team reflexivity may be especially helpful for teams with relatively low performance. Teams that are reflexive tend to learn from previous mistakes, errors, and group processes, which in turn will improve the performance of the team. We propose that this relationship will most likely positively affect learning and final team performance under conditions of relatively poor prior performance. When a team is doing relatively well, the relationship between reflexivity and final team performance will be less clear, as reflexivity and learning is less needed. In a longitudinal study (N = 73 teams), we found support for this idea. As predicted, results indicated that this interaction between team reflexivity and initial team performance on future performance was mediated by team learning. We outline how these findings are important for our understanding of the contingencies of team reflexivity and team performance dynamics. Copyright © 2012 John Wiley & Sons, Ltd.
Adjuvant treatment of early colon cancer with micrometastases: Results of a national survey
Authors: Short Scott S. , Stojadinovic Alexander , Nissan Aviram , Wainberg Zev , Dhall Deepti , Yao Kathy , Bilchik Anton 
Published: February 2012

AbstractBackground and ObjectivesOptimal adjuvant treatment for patients with Stage I/II colon cancer with micrometastases (MM) is unknown. Because there is no known adjuvant treatment‐related benefit, we evaluated whether MM influenced treatment decisions.MethodReview of a national survey from members of the SSO and ASCO.ResultsOf 602 survey responses, 305 (51%) stated that MM had significant prognostic value, 250 (42%) were unsure, and 47 (7%) did not believe that MM held prognostic value. Three hundred seventy‐four (63%) would offer adjuvant therapy in the setting of MM, while 222 (37%) would not. Only 15% routinely performed IHC on lymph nodes. Medical oncologists were more likely to recommend adjuvant therapy compared to surgical oncologists (68% vs. 51%, P = 0.001).ConclusionsMM in colon cancer apparently influenced adjuvant treatment decisions absent known prognostic benefit. Prospective trials are needed to improve the selection of patients for systemic chemotherapy in early, node‐negative colon cancer. J. Surg. Oncol. 2012; 106:119–122. © 2012 Wiley Periodicals, Inc.
Low‐Power Upconversion in Dye‐Doped Polymer Nanoparticles
Authors: Simon Yoan C. , Bai Shuo , Sing Michelle K. , Dietsch Hervé , Achermann Marc , Weder Christoph 
Published: February 2012

AbstractExamples of nanoscale low‐power upconverting systems are rapidly increasing because of their potential application in numerous areas such as bioimaging or drug delivery. The fabrication of dye‐doped cross‐linked rubbery nanoparticles that exhibit upconversion even at relatively low power densities is reported here. The nanoparticles were prepared by surfactant‐free emulsion polymerization of n‐butylacrylate with divinylbenzene as a cross‐linker, followed by dyeing of the resulting particles with a two‐chromophore system composed of a palladium porphyrin sensitizer, and diphenylanthracene. Blue emission (≈440 nm) of these systems was observed upon excitation at 532 nm. In addition to their optical properties, the particles were characterized by electron microscopy and dynamic light scattering.
XatA, an AT‐1 autotransporter important for the virulence of Xylella fastidiosa Temecula1
Authors: Matsumoto Ayumi , Huston Sherry L. , Killiny Nabil , Igo Michele M. 
Published: February 2012

AbstractXylella fastidiosa Temecula1 is the causative agent of Pierce's disease of grapevine, which is spread by xylem‐feeding insects. An important feature of the infection cycle is the ability of X. fastidiosa to colonize and interact with two distinct environments, the xylem of susceptible plants and the insect foregut. Here, we describe our characterization of XatA, the X. fastidiosa autotransporter protein encoded by PD0528. XatA, which is classified as an AT‐1 (classical) autotransporter, has a C‐terminal β‐barrel domain and a passenger domain composed of six tandem repeats of approximately 50 amino acids. Localization studies indicate that XatA is present in both the outer membrane and membrane vesicles and its passenger domain can be found in the supernatant. Moreover, XatA is important for X. fastidiosa autoaggregation and biofilm formation based on mutational analysis and the discovery that Escherichia coli expressing XatA acquire these traits. The xatA mutant also shows a significant decrease in Pierce's disease symptoms when inoculated into grapevines. Finally, X. fastidiosa homologs to XatA, which can be divided into three distinct groups based on synteny, form a single, well‐supported clade, suggesting that they arose from a common ancestor.
An approach to the modeling of viscoelastic damage. Application to the long‐term creep of gypsum rock materials
Authors: Nedjar B. , Le Roy R. 
Published: February 2012

SUMMARYA three‐dimensional phenomenological model is developed to describe the long‐term creep of gypsum rock materials. The approach is based on the framework of continuum damage mechanics where coupling with viscoelasticity is adopted. Specifically, a local damage model based on the concept of yield surface is proposed and deeply investigated. Among the many possibilities, we choose in this work its coupling with a generalized Kelvin–Voigt rheological model to formulate the whole behavior. Long‐term as well as short‐term relaxation processes can be integrated in the model by means of as many as necessary viscoelastic processes. The numerical discretization is described for an easy integration within a finite element procedure. Finally, a set of numerical simulations is given to show the possibilities of the presented model. It shows good agreement with some experimental results found in the literature. Copyright © 2012 John Wiley & Sons, Ltd.
Exploitation of symmetry in graphs with applications to finite and boundary elements analysis
Authors: Koohestani K. 
Published: February 2012

SUMMARYWe present explicit and parametric forms of transformation matrices for three well‐known and widely used symmetry groups: S2, C2v and C4v. Group representation theory is the most powerful method for exploiting symmetry. We propose an efficient algorithm for systematic generation of reducible representations that can be combined linearly to obtain the projection operators. The exact column spaces of these projection operators are calculated and integrated through special orderings, leading to exact explicit and parametric forms of transformation matrices. The transformation matrices could be used directly for block diagonalization of single‐variable scalar field problems. Another algorithm is proposed to extend the application of the method to nonscalar and multivariable field problems. Finally, the generality and efficiency of the proposed method in relation to computation times and the accuracy of results are illustrated through examples from spectral decomposition, free vibration, buckling of FEMs and boundary element analysis of a symmetric field. Copyright © 2012 John Wiley & Sons, Ltd.
A recovery‐based error estimator for finite volume methods of interface problems: Conforming linear elements
Authors: Mu Lin , Jari Rabeea , Conner Loralyn 
Published: February 2012

AbstractIn this article, we present a recovery‐based a posteriori error estimator for finite volume methods which use the conforming linear trial functions to approximate elliptic interface problems. The reliability and efficiency bounds for the error estimator are established by recovering the flux from a weighted L2 projection to H(div) conforming finite element spaces. Numerical experiments are given to support the conclusions. © 2012 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq 2013