bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tri‐Compartmental Restriction Spectrum Imaging Based on 18F‐FDG PET/MR for Identification of Primary Benign and Malignant Lung Lesions
Authors: Liu Xue , Meng Nan , Zhou Yihang , Fu Fangfang , Yuan Jianmin , Wang Zhe , Yang Yang , Xiong Zhongyan , Zou Chao , Wang Meiyun 
Published: June 2024

BackgroundRestriction spectrum imaging (RSI), as an advanced quantitative diffusion‐weighted magnetic resonance imaging technique, has the potential to distinguish primary benign and malignant lung lesions.ObjectiveTo explore how well the tri‐compartmental RSI performs in distinguishing primary benign from malignant lung lesions compared with diffusion‐weighted imaging (DWI), and to further explore whether positron emission tomography/magnetic resonance imaging (PET/MRI) can improve diagnostic efficacy.Study TypeProspective.Population137 patients, including 108 malignant and 29 benign lesions (85 males, 52 females; average age = 60.0 ± 10.0 years).Field Strength/SequenceT2WI, T1WI, multi‐b value DWI, MR‐based attenuation correction, and PET imaging on a 3.0 T whole‐body PET/MR system.AssessmentThe apparent diffusion coefficient (ADC), RSI‐derived parameters (restricted diffusion , hindered diffusion , and free diffusion ) and the maximum standardized uptake value (SUVmax) were calculated and analyzed for diagnostic efficacy individually or in combination.Statistical TestsStudent's t‐test, Mann–Whitney U test, receiver operating characteristic (ROC) curves, Delong test, Spearman's correlation analysis. P < 0.05 was considered statistically significant.ResultsThe , SUVmax were significantly higher, and , ADC were significantly lower in the malignant group [0.717 ± 0.131, 9.125 (5.753, 13.058), 0.194 ± 0.099, 1.240 (0.972, 1.407)] compared to the benign group [0.504 ± 0.236, 3.390 (1.673, 6.030), 0.398 ± 0.195, 1.485 ± 0.382]. The area under the ROC curve (AUC) values ranked from highest to lowest as follows: AUC (SUVmax) > AUC () > AUC () > AUC (ADC) > AUC () (AUC = 0.819, 0.811, 0.770, 0.745, 0549). The AUC (AUC = 0.900) of the combined model of RSI with PET was significantly higher than that of either single‐modality imaging.ConclusionRSI‐derived parameters (, ) might help to distinguish primary benign and malignant lung lesions and the discriminatory utility of was not observed. The RSI exhibits comparable or potentially enhanced performance compared with DWI, and the combined RSI and PET model might improve diagnostic efficacy.Level of Evidence2.Technical EfficacyStage 2.
Sequencing and characterization of human bocavirus genomes from patients diagnosed in Southern France between 2017 and 2022
Authors: Hikmat Houmadi , Le Targa Lorlane , Boschi Celine , Py Justine , Bedotto Marielle , Morand Aurélie , Cassir Nadim , Aherfi Sarah , La Scola Bernard , Colson Philippe 
Published: June 2024

AbstractThe diversity and evolution of the genomes of human bocavirus (HBoV), which causes respiratory diseases, have been scarcely studied. Here, we aimed to obtain and characterize HBoV genomes from patients's nasopharyngeal samples collected between 2017 and 2022 period (5 years and 7 months). Next‐generation sequencing (NGS) used Illumina technology after having implemented using GEMI an in‐house multiplex PCR amplification strategy. Genomes were assembled and analyzed with CLC Genomics, Mafft, BioEdit, MeV, Nextclade, MEGA, and iTol. A total of 213 genomes were obtained. Phylogeny classified them all as of Bocavirus 1 (HBoV1) species. Five HBoV1 genotypic clusters determined by hierarchical clustering analysis of 27 variable genome positions were scattered over the study period although with differences in yearly prevalence. A total of 167 amino acid substitutions were detected. Besides, coinfection was observed for 52% of the samples, rhinoviruses then adenoviruses (HAdVs) being the most common viruses. Principal component analysis showed that HBoV1 genotypic cluster α tended to be correlated with HAdV co‐infection. Subsequent HAdV typing for HBoV1‐positive samples and negative controls demonstrated that HAdVC species predominated but HAdVB was that significantly HBoV1‐associated. Overall, we described here the first HBoV1 genomes sequenced for France. HBoV1 and HAdVB association deserves further investigation.
Cover Image
Authors: Chen Xiaoqiang , Wang Mengdie , Wang Zhiyuan , Liu Xiuling , Cao Wendan , Zhang Na , Qi Yonggang , Cheng Shuiyuang , Huang Wei , Liu Zhong 
Published: June 2024

The cover image is based on the Research Article Theabrownins in dark tea form complexes with tea polysaccharide conjugates by Xiaoqiang Chen et al., https://doi.org/10.1002/jsfa.13431.image
Diosmetin: A dietary flavone as modulator of signaling pathways in cancer progression
Authors: Raza Waseem , Meena Abha , Luqman Suaib 
Published: June 2024

AbstractFlavonoids, constituting the most extensive category of polyphenols, founds in a variety of plants and comprise over 9000 compounds. Diosmetin, O‐methylated flavone (3’,5,7‐trihydroxy‐4’‐methoxyflavone) of flavonoid aglycone diosmin have witnessed a significant surge in recent years. Many studies showed that flavonoids induced cytotoxicity in different organ specific cancer types. Thus, current review evaluates the anticancer potential of diosmetin and shed light on its mechanism of action such as cell cycle regulation, apoptosis via both intrinsic and extrinsic pathway, autophagy and tumour progression and metastasis. It also provides comprehensive analysis of different cancer targets and their role in breast, colon, hepatic, gliomas, leukemia, lung, prostate and skin cancer. Combination studies of diosmetin to improve drug sensitivity and reduce toxicity towards normal cells has been also discussed. Besides, in vitro studies, present review also discuss the anticancer potential of diosmetin on xenograft mice model. Different natural sources of diosmetin, limitations, pharmacokinetic analysis and toxicity study also summarized in current review. The emphasis on enhancing solubility and permeability for clinical utility has been thoroughly highlighted with particular attention given to the utilization of nano formulations to overcome existing barriers. At last, in‐depth analysis of current challenges and a forward‐looking perspective deliberated to address the existing gaps and position it as a promising lead compound for clinical applications in cancer treatment. This discussion is boosted by diosmetin's potential anticancer properties on different cancers, makes valuable candidates in the ongoing quest for effective therapeutic interventions against cancer.
Review of chemical models and applications in Geant4‐DNA: Report from the ESA BioRad III Project
Authors: Tran Hoang Ngoc , Archer Jay , Baldacchino Gérard , Brown Jeremy M. C. , Chappuis Flore , Cirrone Giuseppe Antonio Pablo , Desorgher Laurent , Dominguez Naoki , Fattori Serena , Guatelli Susanna , Ivantchenko Vladimir , Méndez José‐Ramos , Nieminen Petteri , Perrot Yann , Sakata Dousatsu , Santin Giovanni , Shin Wook‐Geun , Villagrasa Carmen , Zein Sara , Incerti Sebastien 
Published: June 2024

AbstractA chemistry module has been implemented in Geant4‐DNA since Geant4 version 10.1 to simulate the radiolysis of water after irradiation. It has been used in a number of applications, including the calculation of G‐values and early DNA damage, allowing the comparison with experimental data. Since the first version, numerous modifications have been made to the module to improve the computational efficiency and extend the simulation to homogeneous kinetics in bulk solution. With these new developments, new applications have been proposed and released as Geant4 examples, showing how to use chemical processes and models. This work reviews the models implemented and application developments for modeling water radiolysis in Geant4‐DNA as reported in the ESA BioRad III Project.
CT‐based synthetic iodine map generation using conditional denoising diffusion probabilistic model
Authors: Gao Yuan , Xie Huiqiao , Chang Chih‐Wei , Peng Junbo , Pan Shaoyan , Qiu Richard L. J. , Wang Tonghe , Ghavidel Beth , Roper Justin , Zhou Jun , Yang Xiaofeng 
Published: June 2024

AbstractBackgroundIodine maps, derived from image‐processing of contrast‐enhanced dual‐energy computed tomography (DECT) scans, highlight the differences in tissue iodine intake. It finds multiple applications in radiology, including vascular imaging, pulmonary evaluation, kidney assessment, and cancer diagnosis. In radiation oncology, it can contribute to designing more accurate and personalized treatment plans. However, DECT scanners are not commonly available in radiation therapy centers. Additionally, the use of iodine contrast agents is not suitable for all patients, especially those allergic to iodine agents, posing further limitations to the accessibility of this technology.PurposeThe purpose of this work is to generate synthetic iodine map images from non‐contrast single‐energy CT (SECT) images using conditional denoising diffusion probabilistic model (DDPM).MethodsOne‐hundered twenty‐six head‐and‐neck patients’ images were retrospectively investigated in this work. Each patient underwent non‐contrast SECT and contrast DECT scans. Ground truth iodine maps were generated from contrast DECT scans using commercial software syngo.via installed in the clinic. A conditional DDPM was implemented in this work to synthesize iodine maps. Three‐fold cross‐validation was conducted, with each iteration selecting the data from 42 patients as the test dataset and the remainder as the training dataset. Pixel‐to‐pixel generative adversarial network (GAN) and CycleGAN served as reference methods for evaluating the proposed DDPM method.ResultsThe accuracy of the proposed DDPM was evaluated using three quantitative metrics: mean absolute error (MAE) (1.039 ± 0.345 mg/mL), structural similarity index measure (SSIM) (0.89 ± 0.10) and peak signal‐to‐noise ratio (PSNR) (25.4 ± 3.5 db) respectively. Compared to the reference methods, the proposed technique showcased superior performance across the evaluated metrics, further validated by the paired two‐tailed t‐tests.ConclusionThe proposed conditional DDPM framework has demonstrated the feasibility of generating synthetic iodine map images from non‐contrast SECT images. This method presents a potential clinical application, which is providing accurate iodine contrast map in instances where only non‐contrast SECT is accessible.
Performance evaluation of iterative PET reconstruction with resolution recovery incorporating Gallium‐68 positron range correction
Authors: Gavriilidis Prodromos , Koole Michel , Marinus Anouk , Jansen Floris P. , Deller Timothy W. , Mottaghy Felix M. , Wierts Roel 
Published: June 2024

AbstractBackgroundThe distance traveled by the positron before annihilation with an electron, the so‐called positron range, negatively effects the positron emission tomography (PET) image quality for radionuclides emitting high‐energy positrons such as Gallium‐68 (68Ga).PurposeIn this study, the effect of a tissue‐independent positron range correction for Gallium‐68 (68Ga‐PRC) was investigated based on phantom measurements. The effect of the 68Ga‐PRC was also explored in four patients.MethodsThe positron range distribution profile of 68Ga in water was generated via Monte Carlo simulation. That profile was mapped to a spatially invariant 3D convolution kernel which was incorporated in the OSEM and Q.Clear reconstruction algorithms to perform the 68Ga‐PRC. In addition, each reconstruction method included point spread function (PSF) modeling and time‐of‐flight information. For both Fluorine‐18 (18F) and 68Ga, the NEMA IQ phantom was filled with a sphere‐to‐background ratio of 10:1 and scanned with the GE Discovery MI 5R PET/CT system. Standard non‐positron range correction (PRC) reconstructions were performed for both radionuclides, while also PRC reconstructions were performed for 68Ga. Reconstructions parameters (OSEM: number of updates, Q.Clear: beta value) were adapted to achieve similar noise levels between the corresponding reconstructions. The effect of 68Ga‐PRC was assessed for both OSEM and Q.Clear reconstructions and compared to non‐PRC reconstructions for 68Ga and 18F in terms of image contrast, noise, recovery coefficient (RC), and spatial resolution. For the clinical validation, 68Ga‐labeled prostate‐specific membrane antigen (68Ga‐PSMA) and 68Ga‐DOTATOC PET scans were included of two patients each. For each PET scan, patients were injected with 1.5 MBq/kg of 68Ga‐PSMA or 68Ga‐DOTATOC and the contrast‐to‐noise ratio (CNR) was calculated and compared to the non‐PRC reconstructions.ResultsFor OSEM reconstructions, including the 68Ga‐PRC improved the RC by 9.4% (3.7%–19.3%) and spatial resolution by 21.7% (4.6 mm vs. 3.6 mm) for similar noise levels. For Q.Clear reconstructions, 68Ga‐PRC modeling improved the RC by 6.7% (2.8%–10.5%) and spatial resolution by 15.3% (5.9 mm vs. 5.0 mm) while obtaining similar noise levels. In the patient data, the use of 68Ga‐PRC enhanced the CNR by 13.2%.ConclusionsIncluding 68Ga‐PRC in the PET reconstruction enhanced the image quality of 68Ga PET data compared to the standard non‐PRC reconstructions for similar noise levels. Limited patient results also supported this improvement.
Development of the Japanese version of the Challenging Experience Questionnaire
Authors: Tani Hideaki , Yonezawa Kengo , Kusudo Keisuke , Barrett Frederick S. , Nakajima Shinichiro , Uchida Hiroyuki 
Published: June 2024

AbstractIntroductionThe therapeutic potential of psychedelics for various mental disorders has gained significant interest. Previous studies have highlighted that psychedelics induce psychoactive effects, including challenging aspects of experiences. These experiences are assessed using the Challenging Experience Questionnaire (CEQ), yet its Japanese version has been unavailable. This study aimed to create a Japanese version of the CEQ.MethodsWe followed the “Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient‐Reported Outcomes (PRO) Measures: Report of the ISPOR Task Force for Translation and Cultural Adaptation.” Initially, two Japanese psychiatrists independently conducted the forward translations. These were then reconciled into a single version, which was back‐translated into English. The original authors reviewed this back‐translation for accuracy, leading to revisions through continuous dialogue until the original authors approved the final version.ResultsThe final, approved back‐translated version of the CEQ is presented in the figure.ConclusionsThis study developed a Japanese version of the CEQ, enabling the assessment of challenging experiences during psychedelic‐assisted therapy for Japanese speakers. Further studies are needed to assess the reliability and validity of this newly translated version.
Neuropsychiatric manifestations due to anticholinergic agents and anabolic steroids ingestion: A case series and literature review
Authors: Talabaki Homa , Soltani Mahkameh , Abbasi Ali , Sharifi Vahid , Salehi Narges , Zakariaei Zakaria 
Published: June 2024

AbstractAnticholinergic toxicity is a common occurrence in the emergency room, making it crucial for emergency clinicians to have a good understanding of this toxidrome. The neuropsychiatric effects of anticholinergic agents and anabolic steroids (ASs) can manifest as symptoms like anxiety, agitation, dysarthria, confusion, seizures, visual hallucinations, bizarre behavior, delirium, psychosis, and coma. When dealing with a conscious patient who has ingested an anticholinergic substance, a detailed history of ingestion can aid clinicians in making an accurate diagnosis. However, the lack of information about the substances consumed can complicate diagnosis. In cases where the exposure is unknown, clinicians should consider anticholinergic poisoning in patients showing signs of altered mental status and physical examination findings consistent with anticholinergic toxicity. We report four cases presenting a range of symptoms, including neuropsychiatric manifestations, following the ingestion of the same bodybuilding powders with anticholinergic properties. All four patients consumed yellow and white powders at the same time and in the same place. Laboratory analysis revealed that yellow powder and white powder contained ASs and cyproheptadine, respectively.
Bronze age horsemen: An evaluation of pathological and nonpathological changes for indicators of “horsemanship syndrome” of the Strzyżów culture population, Poland, 2000–1600 BC
Authors: Hyrchała Anna , Lorkiewicz‐Muszyńska Dorota 
Published: June 2024

AbstractNumerous pathological and nonpathological changes examined on human bones are classified and related to various types of physical activities practiced during life. Some activities in ancient populations can be reconstructed based on studies of specific patterns and types of skeletal changes. Recently, particular attention has been paid to evaluate diagnostic traits that are commonly interpreted as “horsemanship syndrome.” In the present study, as of the time of writing, 100 skeletons from 23 archaeological sites of the Strzyżów culture in south‐eastern Poland have been cataloged and analyzed. Preliminary analysis showed that 31 individuals were of subadult age and 46 adult skeletons were poorly preserved. In further research, authors focused on pathological and nonpathological changes in bone morphology associated with horseback riding among the remaining 23 adult individuals. Diagnostic traits including pelvic and lower limbs entheses, acetabular shape (vertical ovalisation), femoroacetabular morphological changes, subtrochanteric shape (platymeria), and specific vertebral degeneration and specific trauma lesions were analyzed related to biomechanical stress from frequent horseback riding. An evaluation gave results with high level of diagnostic certainty for four individuals and included two males, one female, and one individual whose sex could not be clearly determined due to the fragmented and incomplete preservation of the skull and pelvis. Lower probability was received in the next three cases included one male, one female, and one probably female. This study revealed that a proportion of the Strzyżów culture population developed skeletal changes compatible with riding horses.
Agalactosyl IgG induces liver fibrogenesis via Fc gamma receptor 3a on human hepatic stellate cells
Authors: Ho Cheng‐Hsun , Chang Ting‐Tsung , Lin Hsien‐Chang , Wang Sheng‐Fan 
Published: June 2024

AbstractThe relevance of aberrant serum IgG N‐glycosylation in liver fibrosis has been identified; however, its causal effect remains unclear. Because hepatic stellate cells (HSCs) contribute substantially to liver fibrosis, we investigated whether and through which mechanisms IgG N‐glycosylation affects the fibrogenic properties of HSCs. Analysis of serum IgG1 N‐glycome from 151 patients with chronic hepatitis B or liver cirrhosis revealed a positive correlation between Ishak fibrosis grading and IgG1 with agalactosyl N‐glycoforms on the crystallizable fragment (Fc). Fc gamma receptor (FcγR) IIIa was observed in cultured human HSCs and HSCs in human liver tissues, and levels of FcγRIIIa in HSCs correlated with the severity of liver fibrosis. Additionally, agalactosyl IgG treatment caused HSCs to have a fibroblast‐like morphology, enhanced migration and invasion capabilities, and enhanced expression of the FcγRIIIa downstream tyrosine‐protein kinase SYK. Furthermore, agalactosyl IgG treatment increased fibrogenic factors in HSCs, including transforming growth factor (TGF)‐β1, total collagen, platelet‐derived growth factor subunit B and its receptors, pro‐collagen I‐α1, α‐smooth muscle actin, and matrix metalloproteinase 9. These effects were more pronounced in HSCs that stably expressed FCGR3A and were reduced in FCGR3A knockout cells. Agalactosyl IgG and TGF‐β1 each increased FCGR3A in HSCs. Furthermore, serum TGF‐β1 concentrations in patients were positively correlated with agalactosyl IgG1 levels and liver fibrosis severity, indicating a positive feedback loop involving agalactosyl IgG, HSC‐FcγRIIIa, and TGF‐β1. In conclusion, agalactosyl IgG promotes fibrogenic characteristics in HSCs through FcγRIIIa. © 2024 The Pathological Society of Great Britain and Ireland.
Quercetin allylation and thiol–ene click photopolymerization to produce biobased polymer thermosets with robust thermomechanical properties
Authors: Lechuga Islas Víctor D , Acosta Ortiz Ricardo , Yañez Macías Roberto , Hernández Jiménez Alan I 
Published: June 2024

AbstractThe development of biobased and functionalized monomers along with eco‐friendly photopolymerization processes represent promising methods for the development of renewable and more environmentally friendly thermosets. Thiol–ene ‘click’ photopolymerization is particularly advantageous in this regard; however, the materials derived from this method often exhibit low glass transition temperatures (Tg) and unsuitable thermomechanical properties for applications at room temperature. Herein, we report the synthesis of biobased allyl derivatives from quercetin, a renewable flavonoid compound widely available in fruits, vegetables and plants. We demonstrated the isolation of tetra‐ and penta‐allylated quercetin (Q1 and Q2, respectively) and their subsequent photoactivated thiol–ene polymerization. By introducing a biobased thiol curing agent (PTTMP) derived from glycerol and mercaptopropionic acid, we produced fully biobased crosslinked thermosets with high content of aromatic moieties provided by the framework of the monomers. Real‐time infrared spectroscopy showed the effective thiol–ene photopolymerization of Q1 and Q2 and PTTMP with conversions of 60% and 75%, respectively, after 15 min of UV irradiation. Due to the modulated crosslinking degree from the allyl group functionalization in the monomers, the biobased crosslinked networks showed storage moduli from 420 to 739 MPa, thermal stability from 220 to 257 °C and Tg values ranging from 75 to 90 °C. This work outlines straightforward strategies for creating biobased thermosets that overcome the limited thermomechanical properties of thiol–ene networks and offer potential antimicrobial and antioxidant properties. © 2024 Society of Chemical Industry.
Large cells suppress the reproduction of Varroa destructor
Authors: Zhang Lifu , Shao Linxin , Raza Muhammad Fahad , Zhang Yi , Li Zhigang , Huang Zachary Y. , Chen Yanping , Su Songkun , Han Richou , Li Wenfeng 
Published: June 2024

AbstractBACKGROUNDThe parasitic mite, Varroa destructor has posed a threat to the health and survival of European honey bees, Apis mellifera worldwide. There is a prevailing belief that small comb cells could provide a management tool against Varroa mites. However, the hypothesis that smaller cells can impede Varroa reproduction has not been fully tested. Here, we tested this hypothesis under laboratory conditions by using two distinct Varroa in vitro rearing systems: one involved gelatin capsules of different sizes, specifically size 00 (0.95 mL) versus size 1 (0.48 mL), and the second consisted of brood comb cells drawn on 3D printed foundations with varying cell sizes, ranging from 5.0 mm to 7.0 mm at 0.5 mm intervals.RESULTSThe results showed that mother mites in size 00 cells had significantly lower fecundity and fertility compared to those in size 1 cells. Interestingly, the reproductive suppression in larger cells could be reversed by adding an extra worker larva. Similarly, gonopore size of mother mites was smaller in size 00 cells, but restored with another host larva. Furthermore, both the fecundity and fertility of mother mites decreased linearly with the size of brood comb cells.CONCLUSIONSOur results suggest that the reproduction of V. destructor is hindered by larger cells, possibly because larger brood cells disperse or weaken host volatile chemical cues that are crucial for Varroa reproduction. The insights derived from this study are expected to hold significant implications for the implementation of Varroa management programs. © 2024 Society of Chemical Industry.