bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated proteomic and genomic analysis to identify predictive biomarkers for valproate response in bipolar disorder: a 6-month follow-up study
Authors: Lee Hyunju , Han Dohyun , Hong Kyung Sue , Ha Kyooseob , Kim Hyeyoon , Cho Eun Young , Myung Woojae , Rhee Sang Jin , Kim Jayoun , Ha Tae Hyon , Lee Kang Eun , Jung Hye Won , Lee Yejin , Lee Dongbin , Yu Hyeona , Lee Daseul , Park Yun Seong , Ahn Yong Min , Baek Ji Hyun , Kim Se Hyun 
Published: May 2024

Abstract
Background
Several genetic studies have been undertaken to elucidate the intricate interplay between genetics and drug responses in bipolar disorder (BD). However, there has been notably limited research on biomarkers specifically linked to valproate, with only a few studies investigating integrated proteomic and genomic factors in response to valproate treatment. Therefore, this study aimed to identify biological markers for the therapeutic response to valproate treatment in BD. Patients with BD in remission were assessed only at baseline, whereas those experiencing acute mood episodes were evaluated at three points (baseline, 8 ± 2 weeks, and 6 ± 1 months). The response to valproate treatment was measured using the Alda scale, with individuals scoring an Alda A score ≥ 5 categorized into the acute-valproate responder (acute-VPAR) group. We analyzed 158 peptides (92 proteins) from peripheral blood samples using multiple reaction monitoring mass spectrometry, and proteomic result-guided candidate gene association analyses, with 1,627 single nucleotide variants (SNVs), were performed using the Korean chip.

Results
The markers of 37 peptides (27 protein) showed temporal upregulation, indicating possible association with response to valproate treatment. A total of 58 SNVs in 22 genes and 37 SNVs in 16 genes showed nominally significant associations with the Alda A continuous score and the acute-VPAR group, respectively. No SNVs reached the genome-wide significance threshold; however, three SNVs (rs115788299, rs11563197, and rs117669164) in the secreted phosphoprotein 2 gene reached a gene-based false discovery rate-corrected significance threshold with response to valproate treatment. Significant markers were associated with the pathophysiological processes of bipolar disorders, including the immune response, acute phase reaction, and coagulation cascade. These results suggest that valproate effectively suppresses mechanisms associated with disease progression.

Conclusions
The markers identified in this study could be valuable indicators of the underlying mechanisms associated with response to valproate treatment.
Multi-density crime predictor: an approach to forecast criminal activities in multi-density crime hotspots
Authors: Cesario Eugenio , Lindia Paolo , Vinci Andrea 
Published: May 2024

AbstractThe increasing pervasiveness of ICT technologies and sensor infrastructures is enabling police departments to gather and store increasing volumes of spatio-temporal crime data. This offers the opportunity to apply data analytics methodologies to extract useful crime predictive models, which can effectively detect spatial and temporal patterns of crime events, and can support police departments in implementing more effective strategies for crime prevention. The detection of crime hotspots from geo-referenced data is a crucial aspect of discovering effective predictive models and implementing efficient crime prevention decisions. In particular, since metropolitan cities are heavily characterized by variable spatial densities of crime events, multi-density clustering seems to be more effective than classic techniques for discovering crime hotspots. This paper presents the design and implementation of MD-CrimePredictor (Multi- Density Crime Predictor), an approach based on multi-density crime hotspots and regressive models to automatically detect high-risk crime areas in urban environments, and to reliably forecast crime trends in each area. The algorithm result is a spatio-temporal crime forecasting model, composed of a set of multi-density crime hotspots, their densities and a set of associated crime predictors, each one representing a predictive model to forecast the number of crimes that are estimated to happen in its specific hotspot. The experimental evaluation of the proposed approach has been performed by analyzing a large area of Chicago, involving more than two million crime events (over a period of 19 years). This evaluation shows that the proposed approach, based on multi-density clustering and regressive models, achieves good accuracy in spatial and temporal crime forecasting over rolling prediction horizons. It also presents a comparative analysis between SARIMA and LSTM models, showing higher accuracy of the first method with respect to the second one.
Methylphenidate Versus Placebo for Treating Fatigue in Patients With Advanced Cancer: Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial
Authors: Stone Patrick Charles , Minton Ollie , Richardson Alison , Buckle Peter , Enayat Zinat E. , Marston Louise , Freemantle Nick 
Published: May 2024

PURPOSE To compare effects and side effects of 6 weeks of individually dose-titrated methylphenidate or placebo on fatigue in palliative care patients with advanced cancer. METHODS This is a randomized, double-blind, placebo-controlled, multicenter trial. Eligible patients had advanced incurable cancer and fatigue >3/10. Principal exclusions were hypertension; psychiatric, cardiovascular, cerebrovascular, renal, liver, or blood disorders; substance dependency; and epilepsy. Patients were randomly assigned 1:1 methylphenidate or placebo starting at 5 mg twice daily. Dose of methylphenidate/placebo was titrated once per week, over 6 weeks, up to a maximum of 20 mg three times daily. Trial ended at 10 weeks. Primary outcome was the difference in Functional Assessment of Chronic Illness Therapy Fatigue (FACIT-F) scores between groups at 6 ± 2 weeks. Secondary outcomes included adverse effects, quality of life, and mood. RESULTS One hundred sixty-two patients (73 men; mean, 65.8; standard deviation [SD], 10.3 years) were randomly assigned, and three were excluded from analysis. Seventy-seven were allocated placebo (baseline FACIT-F = 22 [SD, 10]); 82 were allocated methylphenidate (FACIT-F = 20 [SD, 9]). After 6 ± 2 weeks, FACIT-F scores were 1.97 points (95% CI, –0.95 to 4.90; P = .186) higher (better) on methylphenidate than placebo. Across 10 weeks of the study, FACIT-F was nominally higher in the methylphenidate group versus placebo (Diff, 2.20 [95% CI, 0.39 to 4.01]), but this did not reach the minimally clinically important difference (5-points). At 6 weeks, there were no differences between groups in quality-of-life or symptom domains except for depression scores (nominally reduced in the methylphenidate group: Diff, –1.35 [95% CI, –2.41 to –0.30]). There were no differences in mortality or serious adverse events. CONCLUSION After 6 ± 2 weeks of treatment, methylphenidate was not superior to placebo for treating fatigue in advanced cancer. Methylphenidate was safe and well-tolerated.
Revisiting the Civil Examinations in the Qing Dynasty: Popularization and Social Transitions
Authors: Muhui Zhang , Kyungho Kim 
Published: May 2024

Abstract
Recent literature has pointed out the increased stratification and narrowing of the social ladder embedded in the Qing-era civil examinations. This essay sees a clear-cut division between the diminishing opportunity for high-level degrees (above juren 舉人) and the rising exam fever in competing for the licentiate degree (shengyuan 生員) at the grassroots level. This study focuses on the popularization of civil exams in the Qing era from three perspectives: the inflation of the licentiate degree, the surging exam population across society, and the unintended by-product of expanded access to widespread education and literacy culture. Thus, this essay argues that the popularization of civil exams had far-reaching impacts on socioeconomic transitions in Qing China. In addition to the “gatekeeper” function of the civil examinations for selecting officials, the Qing exams triggered new occupations for licentiates and helped initiate self-employment orientations that contributed to accommodating the tremendous surplus population.
Anatomy of the Superstitious Mind: Subjectivity and Interiority in Two Early Twentieth-Century Rebuttals to Liaozhai's Records of the Strange
Authors: Wang Shengyu 
Published: May 2024

Abstract
Focusing on the issue of psychological portrayal, this essay examines two early twentieth-century rebuttals of Liaozhai's Records of the Strange published in newly founded Chinese fiction magazines. Although the two rebuttals lend themselves easily to a didactic interpretation, the essay argues that their demystification of the supernatural is equally in service of literary representation of individualized subjectivity endowed with interiority. Besides aligning itself with the ongoing efforts to recover alternative forms of modernity repressed by the May Fourth discourse, this essay endeavors to contribute to a fuller understanding of the diversity of ideologies, forms, and styles in so-called new fiction.
On Suwenxue 俗文學 and Its Status under Different Literary Views
Authors: Jing 譚靜 Tan , Xiangfei 包向飛 Bao 
Published: May 2024

Abstract
The connotation of suwenxue 俗文學 has an inextricable relationship with a particular view of literature. Different views of literature have their respective prescribed values, which bring different understandings of suwenxue and different evaluations of its status in literary history. Rather than defining suwenxue based on its external features, this article examines it from three representative literary views: the Chinese traditional literary view, the literary view under the Tang-Song transition hypothesis, and Zheng Zhenduo's 鄭振鐸 (1898–1958) literary view. The Chinese traditional literary view centers on articulating Confucian emotions and conveying the Confucian Dao. Accordingly, suwenxue falls within the scope of unorthodox literature and has a lower literary status. The progressive historical view of the Tang-Song transition hypothesis—that suwenxue originated from poetry and prose— represents the direction of literary development and should be accorded high status. Finally, Zheng Zhenduo takes suwenxue as a literary discipline, a fresh and original view that expands the territory of Chinese literature.
Social Fabric or Glitter Bombs?
Authors: Jakobsen Janet R. 
Published: May 2024

Abstract
This essay raises the question of how to understand social differences, including those indexed by trans, queer, antiracist, and feminist studies, as both intersectional and incommensurable. Through an analysis of how oscillation between the poles of binary oppositions works to reinforce hegemony and weave different issues into a hegemonic social fabric, the essay considers how methods and metaphors for trans and queer studies in religion can create counter-hegemonic possibilities. Specifically, in moving from coherent ideas of “the social” as represented by different social relations woven into a hegemonic social fabric to queer and trans ideas of moving and shimmering social relations that might touch across disjunctions, can trans and queer studies in religion contribute to social possibilities in a revolutionary hue?
Archiving Religious Piety and Trans Identity
Authors: Açıkgöz Şahin 
Published: May 2024

Abstract
This article proposes a nonsecular transfeminist critique to interrogate how labels such as political, strategic, and activist are deployed in ways that reproduce exclusionary transgender archives in Turkey. It analyzes the section on religion and spirituality from the South African Gabrielle Le Roux’s activist documentary Proudly Trans in Turkey (2012) as well as Rüstem Ertuğ Altınay’s article “Reconstructing the Transgendered Self as a Muslim, Nationalist, Upper-Class Woman” (2008), which focuses on the statements and performances of Bülent Ersoy, who has been a very popular trans public figure in Turkey since the eighties and who has, to the surprise of many, publicly embraced Islam in the last three decades. Through this analysis, this article demonstrates how a Western secular framework persistently disciplines and limits trans studies in a Turkish context by foregrounding trans people whose agency can be described in terms of resistance or subversion, thus excluding those pious Muslim trans people whose approaches differ.
Pleomorphic adenoma of the nasal cavity in a 21 – year – old patient – case report
Authors: Pomianek Malwina , Ziajor Seweryn , Bednarski Artur , Piasecki Tomasz , Makara Katarzyna , Celarek Victor , Rogalski Paweł , Makara Karolina 
Published: May 2024

Introduction and aim: Adenoma pleomorphum (multiform adenoma) is the most popular bening tumor, that originates from the salivary glands. Neoplasm develops mainly from large salivary glands and its occurrence in the nasal cavity is rare and falls mainly in the 3-6 decade of life. Only 1% of all pleomorphic adenomas develop in the nasal and sinus cavities. Despite being a benign tumor, malignant transformation can occur in 2-10% of cases.
Description of the case: We report a case of a 21-year-old female ethnically Polish patient with nasal multiform adenoma with initial diagnosis, which indicated a polyp. The final diagnosis was based on the histopathological examination of the resected lesion. The tumor was removed by an endoscopic method with no tissue margins, which may increase the risk of recurrence.
Conclusions: Our case demonstrates that despite pleomorphic adenomas typically occurs in the 3rd to 6th decade of life, clinical symptoms are nondistinctive with a polyp and nasal cavity is a very rare location there should be always be increased vigilance leading to choosing best diagnostic measures to form right diagnosis.
Modern Approaches and Future Perspectives on Breast and Ovarian Cancer Prevention Strategies in BRCA1 and BRCA2 Mutation Carriers: A Literature Overview
Authors: Sarnacka Sandra , Kordialik Jakub , Koćwin Julia , Bieganek Paula , Sadłowski Bartosz , Łukaszewicz Stanisław , Pawłowski Piotr , Rybak Julia , Tokarski Michał , Banasiak Angelika 
Published: May 2024

Individuals with BRCA1 and BRCA2 mutations face significantly heightened likelihood of developing breast and ovarian cancers. Besides some lifestyle recommendations, like maintaining physical activity, healthy BMI, possibly early parenthood and breastfeeding, the management of BRCA1/2 mutation carriers includes gene mutation early-detection, screening, risk-reducing surgeries, and chemoprevention. Various prevention strategies exist, all aimed at monitoring patients and mitigating the cancer risks. However, even with the existence of national and international guidelines to direct prevention efforts, there is no ideal protocol that would be universally applicable for all individuals with mutated BRCA gene. This article aims to delve into the currently available surveillance and preventive strategies and explore the potential future avenues for early detection and risk reduction in BRCA mutation carriers.
Obesity - an epidemic of the 21st century – literature review
Authors: Kułak Klaudia , Sztybór Izabela , Kamińska Katarzyna 
Published: May 2024

Introduction and purpose: The article deals with the problem of obesity, which significantly increases the number of cases among children, adolescents and adults all over the world, leading to the occurrence of systemic disorders. A noticeable increase in the incidence of atherosclerosis, metabolic syndrome and diabetes leads to a reduction in life expectancy. The main aim of the work is to emphasize the seriousness of the contemporary problem, which causes impairment of the functioning of many systems. A secondary goal is to indicate the current standards of obesity treatment and how to deal with overweight.

Brief description of the state of knowledge: Obesity is a disease that affects nearly 800 million people around the world and affects every fourth Pole. Uncontrolled weight gain is caused; lifestyle changes, consumption of highly processed foods, and genetic and endocrine factors. It is a chronic disease with a tendency to relapse, with serious consequences and in need of diagnostics, personalized treatment, and often associated with psychological support.

Material and methods: The article analyzes the research to date and the latest treatment methods, which show that a person struggling with obesity is at risk of over 200 complications, including, for example, fatty liver, stroke, type 2 diabetes or cancer.

Results and conclusion: According to our analysis, obesity is a pathological condition that is truly life-threatening. Despite the society's downplay of the problem, people affected by this disease struggle with many comorbidities that worsen their quality of life.
Higher levels of physical activity are associated with less evasive coping, better physical function and quality of life in patients with axial spondyloarthritis
Authors: Carbo Marlies , Paap Davy , van Overbeeke Laura , Wink Freke , Bootsma Hendrika , Arends Suzanne , Spoorenberg Anneke 
Published: May 2024

Objective
To evaluate daily physical activity (PA) in relation to psychosocial factors, such as anxiety, depression and different types of coping strategies, as well as patient- and disease-related factors in patients with axial spondyloarthritis (axSpA).

Methods
Consecutive outpatients from the Groningen Leeuwarden AxSpA (GLAS) cohort completed the modified Short Questionnaire to assess health-enhancing PA (mSQUASH), Hospital Anxiety and Depression Scale (HADS) and Coping with Rheumatic Stressors (CORS) questionnaires, as well as standardized patient- and disease-related assessments. Univariable and multivariable linear regression analyses and comparison of lowest and highest PA tertiles were performed to explore associations between the HADS, CORS, patient- and disease-related factors and PA.

Results
In total, 84 axSpA patients were included; 60% male, mean age 49 (SD ±14) years, median symptom duration 20 (25th-75th percentiles: 12–31) years, mean ASDAS 2.1 (±1.0). Higher PA levels were significantly associated with better scores on patient-reported disease activity (BASDAI), physical function (BASFI) and quality of life (ASQoL). Furthermore, higher levels of PA were associated with less impact of axSpA on wellbeing and lower HADS depression scores. In the multivariable linear regression model, less use of the coping strategy ‘decreasing activities’ (β: -376.4; p 0.003) and lower BMI (β:-235.5; p: 0.030) were independently associated with higher level of PA. Comparison of patients from the lowest and highest PA tertiles showed results similar to those found in the regression analyses.

Conclusion
In this cohort of axSpA patients, higher levels of daily PA were associated with better patient-reported outcomes and lower depression scores. Additionally, the passive coping strategy “decreasing activities” and lifestyle factor BMI were independently associated with PA. Besides anti-inflammatory treatment, coping strategies and lifestyle should be taken into account in the management of individual axSpA patients. Incorporating these aspects into patient education could increase patient awareness and self-efficacy. In the future, longitudinal studies are needed to better understand the complex relationship between patient-, disease- and psychosocial factors associated with daily PA.
Tande nou gwonde! (Hear us roar!)- Youth perspectives of maternal near-misses: Protocol for a photovoice study of young childbearing people’s perspectives of maternal near-misses in northwest Haiti
Authors: MacDonald Tonya , Charles Marie-Carmèle , Dorcely Olès , Darling Elizabeth K. , Greene Saara , Moll Sandra , Logie Carmen , Mbuagbaw Lawrence 
Published: May 2024

Introduction
Globally, a shift is occurring to recognize the importance of young peoples’ health and well-being, their unique health challenges, and the potential they hold as key drivers of change in their communities. In Haiti, one of the four leading causes of death for those 20–24 years old is pregnancy, childbirth, and the weeks after birth or at the end of a pregnancy. Important gaps remain in existing knowledge about youth perspectives of maternal health and well-being within their communities. Youth with lived experiences of maternal near-misses are well-positioned to contribute to the understanding of maternal health in their communities and their potential role in bringing about change.

Objectives
To explore and understand youth perspectives of maternal near-miss experiences that occurred in a local healthcare facility or at home in rural Haiti.

Methods
We will conduct a qualitative, community-based participatory research study regarding maternal near-miss experiences to understand current challenges and identify solutions to improve community maternal health, specifically focused on youth maternal health. We will use Photovoice to seek an understanding of the lived experiences of youth maternal near-miss survivors. Participants will be from La Pointe, a Haitian community served by their local healthcare facility. We will undertake purposeful sampling to recruit approximately 20 female youth, aged 15–24 years. Data will be generated through photos, individual interviews and small group discussions (grouped by setting of near-miss experience). Data generation and analysis are expected to occur over a three-month period.

Ethics and dissemination
Ethics approval will be sought from Centre Médical Béraca in La Pointe, Haiti, and from the Hamilton Integrated Research Ethics Board in Hamilton ON, Canada. We will involve community stakeholders, especially youth, in developing dissemination and knowledge mobilisation strategies. Our findings will be disseminated as an open access publication, be presented publicly, at conferences, and defended as part of a doctoral thesis.
DINAMIKA PENDIDIKAN DI INDONESIA DALAM PERSPEKTIF FILSAFAT
Authors: Wilujeng Sri Rahayu , Syamsuddin M Mukhtasar , Murtiningsih Rr. Siti 
Published: May 2024

Penelitian ini bertujuan untuk menggambarkan sejarah pendidikan di Indonesia secara cara umum, kebijakan pendidikan pada setiap jaman, dan pendidikan di Indonesia dari perpektif filsafat. Penelitian ini adalah penelitian filsafat atas masalah aktual yaitu pendidikan. Dalam penelitian ini digunakan metode linear dengan melalui beberapa tahap yaitu persepsi, refleksi dan menyusun konsepsi. Unsur-unsur metode yang digunakan adalah interpretasi, analisa-sintesa, kesinambungan historis, dan idealisasi. Hasil dari penelitian ini adalah pendidikan di Indonesia semakin mengarah kepada ontologi pendidikan positivistik dan semakin kehilangan orientasi humanistiknya karena melihat manusia tidak secara utuh. Pendidikan lebih memperhatikan aspek kognitif dan mengabaikan aspek lainnya. Nilai-nilai pragmatisme dalam pendidikan semakin menguat pada era reformasi. Pendidikan sebagai program untuk menyiapkan anak didik untuk memenuhi kebutuhan industri. Terjadi reduksi makna pendidikan yang esensinya adalah aktivitas budaya menjadi aktivitas ekonomi. Pendidikan hanya mencetak manusia menjadi homo faber. Pendidikan menghilangkan kesempatan manusia menjadi manusia seutuhnya. Pendidikan sebagai suatu aktivitas khas manusia jauh lebih bermakna dari sekedar mencetak tenaga kerja. Pendidikan adalah upaya memanusiakan manusia.