bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patterning of COC Polymers by Middle‐Energy Ion Beams for Selective Cell Adhesion in Microfluidic Devices
Authors: Aubrecht Petr , Malinský Petr , Novák Josef , Smejkal Jiří , Jagerová Adéla , Matoušek Jindřich , Štofik Marcel , Liegertová Michaela , Luxa Jan , Macková Anna , Malý Jan 
Published: May 2024

AbstractMicrofluidic devices play a crucial role in advanced cell biology applications, including cell separations, cultivations, migration and interaction studies, diagnostic devices, and organ‐on‐chips. One of the frequent purposes of such devices is the ability to selectively address the attachment of cells at defined locations on the surface. This study explores the application of middle‐energy carbon, oxygen, and nitrogen ions to locally modify the surface of cyclic olefin copolymer (COC) thermoplastic material, allowing selective cell growth on patterned polymer surfaces. The investigation considers ion element type, ion beam energy, and ion irradiation fluence, analyzing their influence on the modification effect. Characterization of the modified surfaces involves various surface‐analytical methods such as contact angle, energy dispersive spectroscopy (SEM‐EDX), atomic force microscopy (AFM), x‐ray photoelectron spectroscopy (XPS), rutherford backscattering spectrometry (RBS), and elastic recoil detection analysis (ERDA). The study extends to practical aspects, with a representative cancer cell line, MCF‐7, grown on the patterned surface to evaluate the degree of selective attachment. Additionally, the stability of the irradiated patterns is tested under elevated temperatures beyond the glass transition temperature (Tg), demonstrating the compatibility of the approach with hot embossing technology. The findings underscore the potential of ion beam treatment for COC in cell‐biology‐related applications, offering insights into surface modification techniques for enhanced functionality in microfluidic devices.
Memristors Based on Ni(II)‐tetraaza[14]annulene Complexes: Toward an Unconventional Resistive Switching Mechanism
Authors: Sławek Andrzej , Alluhaibi Lulu , Kowalewska Ewelina , Abdi Gisya , Mazur Tomasz , Podborska Agnieszka , Mech Krzysztof , Marciszko‐Wiąckowska Marianna , Maximenko Alexey , Szaciłowski Konrad 
Published: May 2024

AbstractIn this work, a family of Ni‐based dibenzotetraaza[14]annulene (dtaa) complexes are investigated for their application in memristors (memory resistors). A series of four Ni(II) complexes with different peripheral substituents of the dtaa ligand are successfully synthesized. Based on these compounds, two‐terminal thin‐film devices are fabricated in planar architecture. Four metals with different work functions are tested: Mg, Cu, Ni, and Au. It is demonstrated that ITO|[Ni(Me4dtaa)]|Cu devices show hysteretic behavior and offer stable, robust, and reproducible switching between high‐ and low‐resistive states. An in‐depth spectroscopic characterization of the Ni complex is performed, using radiation from infrared, through visible and ultraviolet, to tender X‐rays. Operando X‐ray fluorescence spectroscopy is used to monitor redox and structural changes upon the polarization of the studied memristor with the external electric field. Density functional theory calculations are used to better understand the electronic structure of the studied material, as well as structural rearrangement after electron injection that may be responsible for the modulation of electric conductivity. Finding a unique case of filamentary‐type resistive switching involving redox reactions of stationary molecules within a molecular solid is postulated. Yet, the formation of these filaments is not related to any significant configurational changes at the atomic scale.
Unravelling Ultra‐Stable Conversion‐Type Zinc‐Ion Storage in Copper Selenides for Flexible Aqueous Batteries
Authors: Lin Mengru , Qi Rui , Zhang Wei , Ren Zhiguo , Si Jingying , Lei Qi , Sun Yuanhe , Li Haitao , He Jianxin , Zhang Qiwen , Zeng Jianrong , Wen Wen , Gao Yi , Li Xiaolong , Zhu Daming 
Published: May 2024

AbstractRocking‐chair configurations based on advanced anodes with reliable zinc‐ion storage can intrinsically avoid the deterioration of flexible zinc‐ion energy devices by corrosion, dendrites, and inadequate mechanical stability of zinc metal, yet the identification of durable anode materials is still challenging. Herein, the first reported conversion‐type Cu2‐xSe is proposed as an ultra‐stable anode for flexible rocking‐chair aqueous zinc‐ion batteries. Differing from these well‐recognized intercalation‐type copper selenide anodes, the unique Cu2‐xSe structure features a preferred thermodynamic deep transformation path, and the high‐reversible conversion reaction is fully illuminated by in situ synchrotron X‐ray diffraction and substantial ex situ characterization, demonstrating an outstanding performance combination of high capacity (150 mAh g−1 at 0.5 A g−1) and record‐high stability (91% capacity retention after 20 000 cycles at 5 A g−1 in Cu2‐xSe||ZnxMnO2 full cells). Consequently, fiber‐shaped batteries using Cu2‐xSe as the anode are successfully assembled and exhibited an ultra‐long life (89.8% capacity retention after 900 cycles) and extraordinary flexibility (98% capacity retention after 4500 cycles of bending), far exceeding those of representative flexible batteries previously reported. The findings provide novel insights into the energy storage mechanism of copper selenides and, as an elegant forerunner, offer a plausible path for the development of rocking‐chair flexible aqueous zinc‐ion batteries.
Self‐Assembled Molecules Fostering Ordered Spatial Heterogeneity for Efficient Ruddlesden‐Popper Perovskite Solar Cells
Authors: Guo Wei , Li Jingguo , Cen Hanlin , Duan Jianing , Yang Yingguo , Yang Xiaolong , Dong Hua , Wu Zhaoxin , Xi Jun 
Published: May 2024

Abstract2D Ruddlesden‐Popper perovskites (RPP) with formamidinium‐cesium (FAC) alloyed cations possess powerful thermal‐moisture stability. However, their photovoltaic performance is hindered by the elusive spatial heterogeneity at multiscale lengths, highly associated with their coupled charge selective contacts. Herein, it reports on how the rational formation of self‐assembly molecules (SAMs) govern the orderliness of the spatial heterogeneity and crystal growth model in FACs‐RPP films, which is proposed to dictate the charge‐carrier dynamics. Unlike the disordered RPP film driven by the amorphous polymeric contacts, the laterally ordered crystallized SAM contacts facilitate a spatially ordered 2D/3D heterogeneity of FACs‐RPP film in long range, where distinct minor 2D phases are tightly coupled in short range. Such ordered heterogeneity can improve the energy transfer efficiency, facilitating the charge‐carrier dynamics in a well‐aligned 2D/3D landscape is discovered. Finally, the champion solar cells using selective SAM‐based FACs‐RPP films (n = 5) yield an efficiency of 18.85% (certified 18.19%) and excellent damp‐heat/operational stability, ranking in the top league of reported 2D RPP solar cells. More importantly, this SAM‐based principle can be adapted to diverse 2D structures, active areas, and substrate types. This work provides design directions for leveraging bottom‐selective contacts to tune spatial heterogeneity in state‐of‐the‐art 2D RPP optoelectronics.
Agricultural land use modeling and climate change adaptation: A reinforcement learning approach
Authors: Stetter Christian , Huber Robert , Finger Robert 
Published: May 2024

AbstractThis paper provides a novel approach to integrate farmers' behavior in spatially explicit agricultural land use modeling to investigate climate change adaptation strategies. More specifically, we develop and apply a computationally efficient machine learning approach based on reinforcement learning to simulate the adoption of agroforestry practices. Using data from an economic experiment with crop farmers in Southeast Germany, our results show that a change in climate, market, and policy conditions shifts the spatial distribution of the uptake of agroforestry systems. Our modeling approach can be used to advance currently used models for ex ante policy analysis by upscaling existing knowledge about farmers behavioral characteristics and combine it with spatially explicit environmental and farm structural data. The approach presents a potential solution for researchers who aim to upscale information, potentially enriching and complementing existing land use modeling approaches.
Peritoneal lavage cytology in patients with curative resection for stage II and III colorectal cancer: A multi‐institutional prospective study
Authors: Kobayashi Hirotoshi , Kotake Kenjiro , Maeda Kotaro , Suto Takeshi , Kawasaki Masayasu , Ueno Hideki , Komori Koji , Ozawa Heita , Koda Keiji , Ohue Masayuki , Funahashi Kimihiko , Takemasa Ichiro , Ishida Hideyuki , Kazama Shinsuke , Shimada Yoshifumi , Morohashi Hajime , Kinugasa Yusuke , Kanemitsu Yukihide , Ochiai Hiroki , Ishihara Soichiro , Itabashi Michio , Sugihara Kenichi , Ajioka Yoichi 
Published: May 2024

AbstractAimTo clarify the usefulness of intraoperative lavage cytology in patients undergoing curative resection for pStage II‐III colorectal cancer in a prospective multicenter study.MethodsPatients preoperatively diagnosed with stage II‐III colorectal cancer between 2013 and 2017 from 20 hospitals were enrolled. Lavage cytology was performed twice during the surgery. The primary endpoint was the effect of lavage cytology on the 5‐year relapse‐free survival (RFS) in patients with pStage II‐III colorectal cancer. The secondary endpoint was the effect of lavage cytology on the 5‐year overall survival (OS) and peritoneal recurrence.ResultsA total of 1378 patients were eligible for analysis. The number of patients with pStage II‐III colorectal cancer was 670 and 708, respectively. Fifty‐four patients (3.9%) had positive cytological results. In pStage II patients, the 5‐year RFS rates with positive and negative cytology were 61.1% and 81.6%, respectively (p = 0.023). The 5‐year OS rates were 67.1% and 91.7%, respectively (p = 0.0083). However, there was no difference in RFS or OS between pStage III patients with positive and negative cytology results. The peritoneal recurrence rates were 11.8% and 1.5% in pStage II patients with positive and negative cytology results, respectively (p = 0.032). These rates were 10.5% and 2.5% in patients with stage III disease, respectively (p = 0.022).ConclusionStage II colorectal cancer patients with negative cytology had better outcomes than those with positive cytology. Peritoneal lavage cytology is useful for predicting peritoneal recurrence after curative resection of stage II‐III colorectal cancer.
Inflammatory Burden Index as a promising new marker for predicting surgical and oncological outcomes in colorectal cancer
Authors: Yamashita Shinji , Okugawa Yoshinaga , Mizuno Naru , Imaoka Hiroki , Shimura Tadanobu , Kitajima Takahito , Kawamura Mikio , Okita Yoshiki , Ohi Masaki , Toiyama Yuji 
Published: May 2024

AbstractAimsThe prognosis of colorectal cancer (CRC) has been historically reliant on the Tumor Node Metastasis (TNM) staging system, but there is variability in outcomes among patients at similar stages. Therefore, there is an urgent need for more robust biomarkers. The aim of this study was to assess the clinical feasibility of the recently reported Inflammatory Burden Index (IBI) for predicting short‐ and long‐term outcomes in patients with CRC.MethodsThis was a retrospective observational study of 555 CRC patients undergoing surgery for primary tumor resection. We determined the prognostic value of preoperative IBI for disease‐free and overall survival, and its predictive value for perioperative risk of infectious complications, including surgical site infection.ResultsIncreased preoperative IBI was significantly associated with advanced disease stage and poor oncological outcome in CRC patients. Higher IBI was independently linked to poorer disease‐free and overall survival. Similar outcomes were observed in a subanalysis focused on high‐risk stage II and stage III CRC patients. Elevated preoperative IBI was significantly correlated with an increased risk of surgical site infection and other postoperative infectious complications. Propensity score‐matching analysis validated the impact of IBI on the prognosis in CRC patients.ConclusionWe established preoperative IBI as a valuable predictive biomarker for perioperative risks and oncological outcomes in CRC patients. Preoperative IBI is useful for designing effective perioperative management and postoperative oncological follow‐up.
Are sun exposure time, dietary patterns, and vitamin D intake related to the socioeconomic status of Portuguese children?
Authors: dos Santos Elizabete A. , Cavalheiro Lígia Araújo Martini , Rodrigues Daniela , Machado‐Rodrigues Aristides , Silva Maria‐Raquel , Nogueira Helena , Padez Cristina 
Published: May 2024

AbstractObjectivesTo investigate the association among sun exposure time, vitamin D intake, dietary patterns, and socioeconomic status in Portuguese children.MethodsParticipants aged 3–11 years (50.1% females) were recruited from public and private schools (n = 118) in the districts of Coimbra (n = 2980), Lisbon (n = 3066), and Porto (n = 2426). Parents reported their children's daily sun exposure time during the summer season and reported children's food consumption, including vitamin D food sources, using standardized questionnaires. Parents' education level was used as a proxy measure to the socioeconomic status (SES). The principal component factor analysis (PCA) method was used to identify dietary patterns. The eight dietary patterns identified were labeled in: “fast food”, “rich in vitamin D”, “sugary drinks”, “vitamin D”, “candies”, “supplements”, “rich in calcium” and “vegetables/healthy”. Linear regression analyses were performed to investigate the association between sun exposure time and dietary patterns according to SES.ResultsA total of 4755 children were included. Children from high SES had significantly longer sun exposure time (p < .001) and more frequently consumed vitamin D supplements (p < .001). “Fast food” pattern showed a negative association with sun exposure time in medium and high SES (p = .014 and p < .001, respectively).ConclusionChildren with lower SES spend less time exposed to the sun, consume fewer dietary sources of vitamin D, and consume more foods rich in fat and sugar.
Dearomative Construction of 2D/3D Frameworks from Quinolines via Nucleophilic Addition/Borate‐Mediated Photocycloaddition
Authors: Shimose Asuha , Ishigaki Shiho , Sato Yu , Nogami Juntaro , Toriumi Naoyuki , Uchiyama Masanobu , Tanaka Ken , Nagashima Yuki 
Published: May 2024

AbstractDearomative construction of multiply‐fused 2D/3D frameworks, composed of aromatic two‐dimensional (2D) rings and saturated three‐dimensional (3D) rings, from readily available quinolines has greatly contributed to drug discovery. However, dearomative cycloadditions of quinolines in the presence of photocatalysts usually afford 5,6,7,8‐tetrahydroquinoline (THQ)‐based polycycles, and dearomative access to 1,2,3,4‐THQ‐based structures remains limited. Herein, we present a chemo‐, regio‐, diastereo‐, and enantioselective dearomative transformation of quinolines into 1,2,3,4‐THQ‐based 6–6–4‐membered rings without any catalyst, through a combination of nucleophilic addition and borate‐mediated [2+2] photocycloaddition. Detailed mechanistic studies revealed that the photoexcited borate complex, generated from quinoline, organolithium, and HB(pin), accelerates the cycloaddition and suppresses the rearomatization that usually occurs in conventional photocycloaddition. Based on our mechanistic analysis, we also developed further photoinduced cycloadditions affording other types of 2D/3D frameworks from isoquinoline and phenanthrene.
Manipulating Atomic‐Coupling in Dual‐Cavity Boride Nanoreactor to Achieve Hierarchical Catalytic Engineering for Sulfur Cathode
Authors: Wang Bin , Wang Lu , Mamoor Muhammad , Wang Chang , Zhai Yanjun , Wang Fengbo , Jing Zhongxin , Qu Guangmeng , Kong Yueyue , Xu Liqiang 
Published: May 2024

AbstractThe catalytic process of Li2S formation is considered a key pathway to enhance the kinetics of lithium‐sulfur batteries. Due to the system‘s complexity, the catalytic behavior is uncertain, posing significant challenges for predicting activity. Herein, we report a novel cascaded dual‐cavity nanoreactor (NiCo−B) by controlling reaction kinetics, providing an opportunity for achieving hierarchical catalytic behavior. Through experimental and theoretical analysis, the multilevel structure can effectively suppress polysulfides dissolution and accelerate sulfur conversion. Furthermore, we differentiate the adsorption (B−S) and catalytic effect (Co−S) in NiCo−B, avoiding catalyst deactivation caused by excessive adsorption. As a result, the as‐prepared battery displays high reversible capacity, even with sulfur loading of 13.2 mg cm−2 (E/S=4 μl mg−1), the areal capacity can reach 18.7 mAh cm−2.
Fluorescence Lifetime Imaging of Lipid Heterogeneity in the Inner Mitochondrial Membrane with a Super‐photostable Environment‐Sensitive Probe
Authors: Wang Junwei , Taki Masayasu , Ohba Yohsuke , Arita Makoto , Yamaguchi Shigehiro 
Published: May 2024

AbstractThe inner mitochondrial membrane (IMM) undergoes dynamic morphological changes, which are crucial for the maintenance of mitochondrial functions as well as cell survival. As the dynamics of the membrane are governed by its lipid components, a fluorescent probe that can sense spatiotemporal alterations in the lipid properties of the IMM over long periods of time is required to understand mitochondrial physiological functions in detail. Herein, we report a red‐emissive IMM‐labeling reagent with excellent photostability and sensitivity to its environment, which enables the visualization of the IMM ultrastructure using super‐resolution microscopy as well as of the lipid heterogeneity based on the fluorescence lifetime at the single mitochondrion level. Combining the probe and fluorescence lifetime imaging microscopy (FLIM) showed that peroxidation of unsaturated lipids in the IMM by reactive oxygen species caused an increase in the membrane order, which took place prior to mitochondrial swelling.
Atomically Precise Chiral Metal Nanoclusters for Circularly Polarized Light Detection
Authors: He Wei‐Miao , Zha Jiajia , Zhou Zhan , Cui Yu‐Jia , Luo Peng , Ma Lufang , Tan Chaoliang , Zang Shuang‐Quan 
Published: May 2024

AbstractCircularly polarized light (CPL) detection is of great significance in various applications such as drug identification, sensing and imaging. Atomically precise chiral metal nanoclusters with intense circular dichroism (CD) signals are promising candidates for CPL detection, which can further facilitate device miniaturization and integration. Herein, we report the preparation of a pair of optically active chiral silver nanoclusters [Ag7(R/S‐DMA)2(dpppy)3] (BF4)3 (R/S‐Ag7) for direct CPL detection. The crystal structure and molecular formula of R/S‐Ag7 clusters are confirmed by single‐crystal X‐ray diffraction and high‐resolution mass spectrometry. R/S‐Ag7 clusters exhibit strong CD spectra and CPL both in solution and solid states. When used as the photoactive materials in photodetectors, R/S‐Ag7 enables effective discrimination between left‐handed circularly polarized and right‐handed circularly polarized light at 520 nm with short response time, high responsivity and considerable discrimination ratio. This study is the first report on using atomically precise chiral metal nanoclusters for CPL detection.
Unpacking the prevalence: A warning against overstating the recently narrowed gap for Black autistic youth
Authors: Fannin Danai Kasambira , Williams Ed‐Dee G. , Fuller Marcus , Pearson Jamie N. , Boyd Brian A. , Drame Elizabeth R. , Taylor Jonte' , Dickerson Aisha S. , Spinks‐Franklin Adiaha , Coles‐White D' Jaris 
Published: May 2024

AbstractRecent findings from the Centers for Disease Control and Prevention's (CDC) Autism and Developmental Disabilities Monitoring (ADDM) Network's 2020 prevalence report indicate that disparities in autism diagnoses between Black and White youth have narrowed, reflecting improved screening, awareness, and access to services (Maenner et al., 2023. Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, D.C.: 2002), 72, 1–14.). Claims of reducing disparities beyond prevalence rates, however, are not fully supported, as indicated by the reality that Black youth whose screenings indicate autistic traits are still not being referred for full evaluation or early intervention services at the same rate as their White peers (Major et al., 2020. Autism, 24, 1629–1638; Smith et al., 2020. Pediatrics, 145, S35–S46.). Black 8‐year‐olds identified as autistic still experience disparate educational placements (Waitoller et al., 2010. The Journal of Special Education. 44, 29–49.) where services may not be autism‐specific or have Individual Education Plan goals only focused on “behavior problems” (Severini et al., 2018. Journal of Autism and Developmental Disorders, 48, 3261–3272.), are served in the most restrictive environments (Skiba et al., 2006. Exceptional Children, 72, 411–424.) and lack consistent augmentative and alternative communication support (Pope et al., 2022. American Journal of Speech‐Language Pathology, 31, 2159–2174.). Additionally, ADMM researchers report consistent disparities in the identification of co‐occurring intellectual disability where Black autistic children have significantly more co‐occurrences than White autistic children. The purpose of this commentary is to first examine the assertion that the narrowed gap indicates, “…improved…access to services among historically underserved groups,” (p. 9) (Maenner et al., 2023. Morbidity and Mortality Weekly Report. Surveillance Summaries (Washington, D.C.: 2002), 72, 1–14.). We will then recommend strategies to address the ongoing disparities.
Probing the Origin of Overpotential for Sodium‐Oxygen Batteries with Distribution of Relaxation Time
Authors: Ma Dejing , Chen Juan , Yu Fengjiao , Chen Yuhui 
Published: May 2024

AbstractSodium‐oxygen batteries are emerging as new battery systems. Deep understanding of the origin of overpotential and the kinetic process in sodium‐oxygen batteries remain challenging yet critical. We apply a method of distribution of relaxation time (DRT) to decipher the electrochemical impedance spectroscopy (EIS), allowing us to monitor the changes of different kinetic processes during the discharging and charging. The origin of the overpotential in a battery was further comprehensively investigated combining DRT analysis with differential electrochemical mass spectrometry, Raman and other characterizations. Overpotential is found to primarily stem from oxygen mass transport during discharging, and from poor solid‐solid contact at the electrode surface during charging. Our work demonstrates the study of kinetic processes using DRT analysis, and suggests effective ways to improve the performances of sodium‐oxygen batteries.