bluuebunny/crossref_metadata_2025_split huggingface dataset:
A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques
Authors: Adam Awadalkareem , Woolsey Courtney , Lu Hannah , Plante Kenneth , Wallace Shannon M. , Rodriguez Leslie , Shinde Divya P. , Cui Yingjun , Franz Alexander W.E. , Thangamani Saravanan , Comer Jason E. , Weaver Scott C. , Wang Tian 
Published: May 2024

AbstractChikungunya virus (CHIKV), which induces chikungunya fever and chronic arthralgia, is an emerging public health concern. Safe and efficient vaccination strategies are needed to prevent or mitigate virus-associated acute and chronic morbidities for preparation of future outbreaks. Eilat (EILV)/CHIKV, a chimeric alphavirus which contains the structural proteins of CHIKV and the non-structural proteins of EILV, does not replicate in vertebrate cells. The chimeric virus was previously reported to induce protective adaptive immunity in mice. Here, we assessed the capacity of the virus to induce quick and durable protection in cynomolgus macaques. EILV/CHIKV protected macaques from wild-type (WT) CHIKV infection one year after a single dose vaccination. Transcriptome andin vitrofunctional analyses reveal that the chimeric virus triggered toll-like receptor signaling and T cell, memory B cell and antibody responses in a dose-dependent manner. Notably, EILV/CHIKV preferentially induced more durable, robust, and broader repertoire of CHIKV-specific T cell responses, compared to a live attenuated CHIKV 181/25 vaccine strain. The insect-based chimeric virus did not cause skin hypersensitivity reactions in guinea pigs sensitized to mosquito bites. Furthermore, EILV/CHIKV induced strong neutralization antibodies and protected cynomolgus macaques from WT CHIKV infection within six days post vaccination. Transcriptome analysis also suggest that the chimeric virus induction of multiple innate immune pathways, including Toll-like receptor signaling, type I IFN and IL-12 signaling, antigen presenting cell activation, and NK receptor signaling. Our findings suggest that EILV/CHIKV is a safe, highly efficacious vaccine, and provides both rapid and long-lasting protection in cynomolgus macaques.
BioInformatics Agent (BIA): Unleashing the Power of Large Language Models to Reshape Bioinformatics Workflow
Authors: Xin Qi , Kong Quyu , Ji Hongyi , Shen Yue , Liu Yuqi , Sun Yan , Zhang Zhilin , Li Zhaorong , Xia Xunlong , Deng Bing , Bai Yinqi 
Published: May 2024

AbstractBioinformatics plays a crucial role in understanding biological phenomena, yet the exponential growth of biological data and rapid technological advancements have heightened the barriers to in-depth exploration of this domain. Thereby, we proposeBio-InformaticsAgent (BIA), an intelligent agent leveraging Large Language Models (LLMs) technology, to facilitate autonomous bioinformatic analysis through natural language. The primary functionalities ofBIAencompass extraction and processing of raw data and metadata, querying both locally deployed and public databases for information. It further undertakes the formulation of workflow designs, generates executable code, and delivers comprehensive reports. Focused on the single-cell RNA sequencing (scRNA-seq) data, this paper demonstratesBIA’s remarkable proficiency in information processing and analysis, as well as executing sophisticated tasks and interactions. Additionally, we analyzed failed executions from the agent and demonstrate prospective enhancement strategies including selfrefinement and domain adaptation. The future outlook includes expandingBIA’s practical implementations across multi-omics data, to alleviating the workload burden for the bioinformatics community and empowering more profound investigations into the mysteries of life sciences.BIAis available at:https://github.com/biagent-dev/biagent.
Device-Independent Quantum Key Distribution with Arbitrarily Small Nonlocality
Authors: Wooltorton Lewis , Brown Peter , Colbeck Roger 
Published: May 2024

Device-independent quantum key distribution allows two users to set up shared cryptographic key without the need to trust the quantum devices used. Doing so requires nonlocal correlations between the users. However, in Farkas [] it was shown that for known protocols nonlocality is not always sufficient, leading to the question of whether there is a fundamental lower bound on the minimum amount of nonlocality needed for any device-independent quantum key distribution implementation. Here, we show that no such bound exists, giving schemes that achieve key with correlations arbitrarily close to the local set. Furthermore, some of our constructions achieve the maximum of 1 bit of key per pair of entangled qubits. We achieve this by studying a family of Bell inequalities that constitute all self-tests of the maximally entangled state with a single linear Bell expression. Within this family there exist nonlocal correlations with the property that one pair of inputs yield outputs arbitrarily close to perfect key. Such correlations exist for a range of Clauser-Horne-Shimony-Holt values, including those arbitrarily close to the classical bound. Finally, we show the existence of quantum correlations that can generate both perfect key and perfect randomness simultaneously, while also displaying arbitrarily small Clauser-Horne-Shimony-Holt violation. This opens up the possibility of a new class of cryptographic protocol.

Published by the American Physical Society
2024
New Directions for Axionlike Particle Searches Combining Nuclear Reactors and Haloscopes
Authors: Arias-Aragón Fernando , Brdar Vedran , Quevillon Jérémie 
Published: May 2024

In this Letter, we propose reactoscope, a novel experimental setup for axionlike particle (ALP) searches. Nuclear reactors produce a copious number of photons, a fraction of which could convert into ALPs via Primakoff process in the reactor core. The generated flux of ALPs leaves the nuclear power plant and its passage through a region with a strong magnetic field results in the efficient conversion to photons that can be detected. Such magnetic field is the key component of axion haloscope experiments. Adjacent nuclear reactor and axion haloscope experiments exist in Grenoble, France. There, the Institut Laue-Langevin research reactor is situated only ∼700  m from GrAHal, the axion haloscope platform designed to offer several volume and magnetic field (up to 43 T) configurations. We derive sensitivity projections for photophilic ALP searches with the institute and GrAHal, and also scrutinize analogous realizations, such as the one comprising the Axion Solar Telescope experiment at CERN and the Bugey nuclear power plant. The results that we obtain complement and extend the reach of existing laboratory experiments, e.g., the light-shining-through-walls experiment. While the derived sensitivities are not competitive when compared to the astrophysical limits, our analysis is free from the assumptions associated with those limits.

Published by the American Physical Society
2024
Cognitive board diversity and profitability – evidence from Islamic banks in Southeast Asia
Authors: Mukhibad Hasan , Setiawan Doddy , Aryani Y. Anni , Falikhatun Falikhatun 
Published: May 2024

PurposeLiterature on the board diversity of Islamic banks (IB) found limited knowledge of the “deep-level” attribute. This study aims to explain the impact of the board diversity attributes (education levels, educational backgrounds and the interactions between these two attributes of diversity) on profitability.Design/methodology/approachThe research sample is 37 fully flagged IBs from five Southeast Asian countries, covering nine years (2010–2019). Data were analyzed using the two-step system generalized moment (2SYS-GMM) method.FindingsWe found that the cognitive conflict between the board of directors (BOD) and the Shariah Supervisory Board (SSB), which has heterogeneity in its education level and educational background, positively affects profitability. These results reinforce the resources dependence theory (RDT) approach that having boards with heterogeneous characteristics is beneficial for IB.Practical implicationsThe findings of this study would offer useful information for Islamic banking authorities to revise or formulate rules and guidelines and make a greater effort to implement corporate governance (CG) reform measures by determining educational level and background as a requirement to become a member of a BOD or an SSB.Originality/valueThis paper contributes in three ways: (1) we use the “deep-level” diversity attributes of the BOD and the SSB, (2) it focuses on cognitive conflict in boards by presenting the expertise diversity of the BOD and SSB and (3) we interact with the level of education to evaluate the effect of a cognitive conflict.
The effects of board compensation on the voluntary establishment of an internal audit function
Authors: Rönkkö Jaakko , Paananen Mikko , Lahikainen Aleksi 
Published: May 2024

PurposeThis study examines the effects of board members’ compensation on the voluntary establishment of an internal audit function in publicly listed firms. While previous studies have identified some individual determinants related to the voluntary establishment of an internal audit function, the existing evidence on how board members’ compensation affects voluntary use of internal audit is, at best, ambiguous, scarce and incoherent.Design/methodology/approachBoard compensation is a central incentive instrument in the classic principal–agent relationship between the owners and board members. The theme is empirically examined by using data compiled from Finnish publicly listed companies for the period 2015 to 2018. Since the dependent variable of the study is a binary variable, the logistic regression method was chosen as the statistical method of the study.FindingsOur results unequivocally show that generous compensation of the board members increases the likelihood of establishing an internal audit function. Thus, we conclude that good corporate governance can be improved through generous compensation of board members.Originality/valueIdentifying the determinants of internal audit is vital to better understand the mechanisms that facilitate firms' improvement of internal control and risk management in terms of voluntarily adopting an internal audit function, and the implementation of good governance in general. Although numerous determinants of internal audit have been identified in previous studies, this study showed that one of the key determinants has so far been overlooked; namely, the remuneration of board members.
Organizational mission statement components: a comparative study between Indian and Singaporean mission statements in the healthcare sector via Python analysis
Authors: Zairbani Abdulkader , Senthil Kumar J.P. 
Published: May 2024

PurposeThis paper aims to compare the mission statements of Indian and Singaporean firms in the healthcare sector, and define the main components of Indian and Singaporean mission statements.Design/methodology/approachThe study was based on a network analytic approach and content analysis. The research was performed on 200 companies (100 Indian companies and 100 Singaporean companies). For each company, we searched for a mission statement published in the company website. Nonnegative Matrix Factorization (NMF) in Python programming language was utilized to obtain the differences in the components of mission statements between Indian and Singaporean firms.FindingsThe study results indicate a similarity and variation between Indian and Singaporean mission statements. Both countries are more concerned about patients, service, community, quality, and healthcare in their mission statements, but Indian mission statements emphasize quality, affordable price, and technology more than Singaporean firms. In contrast, Singaporean mission statements tend to highlight innovation and company value. This research will assist strategic managers in identifying the mission statement components and choosing the right strategy for the organization.Originality/valueThis study contributes to the literature and ethos theory by identifying and distinguishing the paramount differences between the Indian and Singaporean mission statement components in the healthcare sector.
Explore the relationship between childcare gap policies and children’s social quality: a comparative analysis of European countries
Authors: Yu Wai Kam , Chau Ruby Chui Man , Yu Clement , Ho Grace 
Published: May 2024

PurposeThis article focuses on children’s social quality. Social quality can be understood as the extent to which people can engage in the social, economic, and cultural lives of their communities, under conditions that strengthen their well-being and potential. This article has two purposes. The first is to develop a league table ranking 23 countries’ children’s social quality based on comparative data. The second is to examine the correlation between these countries' commitment to promoting children’s social quality and reducing the child care gap, where childcare is insufficiently covered by child care leave or Early Childhood Education and Care.Design/methodology/approachWe analyse the findings obtained from the children’s social quality league table and the child care gap league table for the 23 countries.FindingsThe findings reveal mixed relationships between the children’s social quality league table and the child care gap league table. These findings indicate that we cannot assume that countries prioritizing the reduction of the child care gap automatically possess the capacity or willingness to promote other aspects of children’s welfare. They also highlight the significance of encouraging countries to enhance their children’s social quality as a way to promote children’s welfare rather than solely reducing the child care gap.Originality/valueChildren’s social quality is a new research area. To explore it, this article makes an innovative attempt by exploring the connection between social quality, children’s welfare, and the child care gap. The league table of children’s social quality this article developed is the first of its kind.
My online self identifies with you, but my offline self skips you: the duality of online and offline personalities in identification with the endorser
Authors: Jeon Yongwoog Andrew 
Published: May 2024

PurposeThe current study examines a novel model that examines how the online and offline or general personality of the same person predicts social identification with the endorser in a message and their subsequent online behaviors (e.g. ad-skipping) on social media, both differentially and simultaneously.Design/methodology/approachReal-time ad-skipping behaviors were tracked and analyzed across three online experiments.FindingsThe results supported the model explicating the dual and simultaneous influence of offline and online personalities on ad-skipping behaviors. Specifically, in response to a skippable video ad, online and offline personalities respectively increase and decrease viewers’ identification with the endorser. Consequently, the higher or lower the identification, the lower or higher the rate of ad-skipping behaviors.Research limitations/implicationsThe current study will benefit from a larger set of real-world data (i.e. big data) to enhance the generalizability of the findings, supporting the model.Practical implicationsWith the growing prevalence of the gap between online and offline self-identities driven by social media usage, this paper suggests that the ad message needs to address the dual influence of both online and offline identities on ad-skipping behaviors.Originality/valueThe current study tests a novel model that shows that the online and offline personalities of the same person concurrently influence one’s behavior on the Internet, rather than separately.
Mitigating perceived overload of communication visibility: the role of ESM policies
Authors: Sun Yuan , Fang Shuyue , Jeyaraj Anand , Zhu Mengyi 
Published: May 2024

PurposeThis study aims to explore how communication visibility affects employees’ work engagement from the negative perspective of employees’ perceived overload in the context of enterprise social media (ESM) and the role of ESM policies in the relationship between communication visibility and perceived overload.Design/methodology/approachThis study examines how communication visibility (i.e. message transparency and network translucence) affects employees’ perceived overload (i.e. information overload and social overload), which in turn affects employees’ work engagement, and how ESM policies moderate the relationship between communication visibility and perceived overload. Partial least squares (PLS) analysis was conducted on data gathered from 224 ESM users in workplaces.FindingsCommunication visibility has significant positive impacts on perceived overload, perceived overload has significant negative impacts on work engagement and ESM policies negatively moderate the relationships between communication visibility and perceived overload, except for the relationship between message transparency and social overload.Practical implicationsThe findings provide new insights for organizational managers to formulate ESM policies to mitigate perceived overload and guidance for ESM developers to improve ESM functions to alleviate perceived overload.Originality/valueThis study provides empirical evidence to explain the role of communication visibility and perceived overload in employees’ work engagement, which contributes to the existing literature on the negative impacts of communication visibility.
The effect of non-audit fees on interest payments classification shifting: does internal governance and firm financial well-being matter?
Authors: Hessian Mohamed , Zalata Alaa Mansour , Hussainey Khaled 
Published: May 2024

PurposeThis study examines the effect of non-audit fees (NAF) provisions on interest payments classification shifting. In addition, we investigate to what extent the NAF economic bonding and interest payments classification shifting is contingent on internal governance and firm financial well-being.Design/methodology/approachThis study employed probit regression using a sample of UK non-financial firms indexed in FT UK (500) over the period from 2009 to 2017.FindingsWe find evidence that the economic bonding of NAF between external auditors and their clients is more likely to encourage managers in UK firms to manipulate operating cash flows through interest payment classification shifting. In addition, and interestingly, our results evince that classification-shifting may be the less costly and soft choice of managers in firms with strong governance and charging higher NAF. Furthermore, we show that financially distressed firms associated with their auditors in purchasing non-audit services are more prone to attempting to manipulate and engage in interest payments classification-shifting. Our result did not provide a significant effect of external auditor tenure on the interest payments classification shifting.Research limitations/implicationsOur findings are subject to the following limitations: First, this study uses a composite index to measure the quality of internal corporate governance. It focuses only on the board of directors, but this index does not reflect other internal governance mechanisms. Second, this study is subject to limited study time due to the implementation of key IFRS standards (IFRS 9 Financial Instruments and IFRS 15 Revenue from Contract with Customers) from 2018–2019.Practical implicationsThis study was motivated by the UK’s Financial Reporting Council regulators' pressure on the Big 4 audit firms to move more audit time into main auditing activities, reduce cross-selling to audit clients and separate their audit practices by 2024. Overall, we provide new evidence that directs a close spotlight on the threats of NAF that are potentially useful to regulators, shareholders and investors.Originality/valueIt is motivated by the UK’s Financial Reporting Council regulators' pressure on the Big 4 to move more audit firm time into main auditing activities, reduce cross-selling to audit clients and separate their audit practices by 2024. Overall, we provide new evidence that directs a close spotlight on the threats of NAS that are potentially useful to regulators, shareholders and investors.
Revisiting the relationship between state governance, employment, water quality and agricultural productivity in N-11 countries
Authors: Thai Thi Hong Minh 
Published: May 2024

PurposeThe agriculture sector is crucial for all economies, especially the developing ones. However, agricultural production is influenced by government intervention, which outshines the significant role of good governance indicators in agricultural productivity. In addition to this, the major climate changes also posed various challenges and led to water shortages and yield losses. Thus affecting agricultural production. In this paper, we address the issue by determining the association between state governance and agricultural productivity in N-11 countries.Design/methodology/approachPanel data have been collected from 2000 to 2021 through the Governance Indicator, World Development Indicator and World Bank databases. For data analysis, the researcher has utilized the autoregressive distributed lag (ARDL) estimations.FindingsThrough ARDL estimations, it is suggested that corruption (CC), employment in agriculture (EAG), political stability and violence absence (PS), rule of law (RL), regulatory equality (RQ) and water quality (WQ) significantly impact agricultural productivity (AGP) in the long run. In the short run, the impact of RL on AGP has been significant.Research limitations/implicationsThis study follows the method of data collection from secondary sources, which hinders the effectiveness of this study as, on the basis of the respective data, the potential of the researcher to get specific answers to research questions has been affected. Also, this study examines the context of N-11 countries from 2000 to 2021, which exerts a geographical limitation. While exploring the association between state governance and agricultural productivity, this study neglects the internal aspects of implementing state policies in firms.Originality/valueOn practical grounds, the significant association demonstrated by this study encourages agricultural firms to keenly consider state policies to gain sustainable agricultural development. Moreover, this study encourages agricultural firms to efficiently follow governance policies for efficient productivity. The outcomes of the study have shown that agricultural employment and governance infrastructure can efficiently enhance agricultural productivity. Besides, as per the results, water quality also positively impacts agricultural productivity; thus, relevant steps can be taken by the agricultural sector to improve the quality of water.