bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluasi Terapi Aspirin dan Non Aspirin Terhadap Nilai PTT aPTT Pada Kejadian Stroke Berulang di RSUD Dungus Madiun
Authors: Nawangsari Palupi 
Published: April 2024

Stroke adalah manifestasi klinik dari gangguan fungsi serebral, baik fokal maupun global, yang berlangsung cepat selama lebih dari 24 jam, atau berakhir dengan kematian tanpa ditemukan penyebab selain daripada gangguan vaskular. Pencegahan stroke berulang salah satunya, menggunakan terapi antiplatelet sebagai pengencer darah. Tujuan penelitian ini adalah mengetahui gambaran, perbandingan perbedaan terapi aspirin dan non aspirin pada kejadian stroke berulang di RSUD Dungus Madiun. Jenis penelitian adalah Desain deskriptif kuantitatif dengan metode cohort pada data rekam medis, hasil laboratorium PTT aPTT. Jumlah data dan sampel sebanyak 10 pasien.
Karakteristik pasien dengan jenis kelamin yang mengalami stroke didominasi 60% laki-laki 40% perempuan pada rentang usia 55-64 tahun sebanyak 50%, riwayat merokok sebanyak 60% dan dengan penyakit penyerta terbanyak yaitu hipertensi dan hiperlipidemia 40%. Pengunaan terapi aspirin sebanyak 50% dan non aspirin sebanyak 50%. Terapi aspirin maupun non aspirin tidak terdapat perbedaan yang signifikan terhadap nilai PTT aPTT, tidak terdapat kejadian stroke berulang pada penggunaan terapi aspirin maupun non aspirin.
Systematic review of predictive maintenance and digital twin technologies challenges, opportunities, and best practices
Authors: Abd Wahab Nur Haninie , Hasikin Khairunnisa , Wee Lai Khin , Xia Kaijian , Bei Lulu , Huang Kai , Wu Xiang 
Published: April 2024

Background
Maintaining machines effectively continues to be a challenge for industrial organisations, which frequently employ reactive or premeditated methods. Recent research has begun to shift its attention towards the application of Predictive Maintenance (PdM) and Digital Twins (DT) principles in order to improve maintenance processes. PdM technologies have the capacity to significantly improve profitability, safety, and sustainability in various industries. Significantly, precise equipment estimation, enabled by robust supervised learning techniques, is critical to the efficacy of PdM in conjunction with DT development. This study underscores the application of PdM and DT, exploring its transformative potential across domains demanding real-time monitoring. Specifically, it delves into emerging fields in healthcare, utilities (smart water management), and agriculture (smart farm), aligning with the latest research frontiers in these areas.

Methodology
Employing the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) criteria, this study highlights diverse modeling techniques shaping asset lifetime evaluation within the PdM context from 34 scholarly articles.

Results
The study revealed four important findings: various PdM and DT modelling techniques, their diverse approaches, predictive outcomes, and implementation of maintenance management. These findings align with the ongoing exploration of emerging applications in healthcare, utilities (smart water management), and agriculture (smart farm). In addition, it sheds light on the critical functions of PdM and DT, emphasising their extraordinary ability to drive revolutionary change in dynamic industrial challenges. The results highlight these methodologies’ flexibility and application across many industries, providing vital insights into their potential to revolutionise asset management and maintenance practice for real-time monitoring.

Conclusions
Therefore, this systematic review provides a current and essential resource for academics, practitioners, and policymakers to refine PdM strategies and expand the applicability of DT in diverse industrial sectors.
Reimagining urban habitats to benefit people and nature
Authors: Threlfall Caragh G. , Farrell Claire , Lequerica Tamara Manuel E. , Hochuli Dieter F. 
Published: April 2024

ABSTRACT
Urbanisation is a leading cause of global biodiversity loss, imposing the most rapid and ecologically damaging impacts of any human driven land-use change. Despite the trend of biodiversity decline, urban nature provides many health, wellbeing and workplace productivity benefits to city dwellers. Hence, there is an urgent need to return nature to cities not only to conserve biodiversity, but also to maintain human experiences of nature. To meet this challenge, there are currently significant global attempts to re-green cities to improve environmental condition, including restoring habitat for biodiversity. However, many barriers to widespread implementation still exist, including competition for limited space, a lack of technical capacity, and a disengaged community. New approaches to urban restoration are urgently needed that suit the small fragments of space available, and that can deliver multiple benefits not only to conserve urban biodiversity but also to reconnect people with nature. To overcome these challenges, an ‘ecology with cities’ perspective, combining horticultural, ecological and social approaches to urban habitat management and restoration, is needed. Significant opportunities exist for urban ecologists and zoologists to engage with practitioners and the community to co-develop and implement approaches to successfully achieve the aim of creating biodiverse urban environments.
Tourism Policies and Performance of Nigerian Heritage Sites
Authors: Adetola Bukola Omotomilola , Akinola Olagoke, Oluseyi , Aina Ayeni, Dorcas 
Published: April 2024

Background: Tourism policies have a significant impact on the preservation, promotion, and overall performance of heritage sites for both domestic and international tourists. This review provides insights into the entities responsible for tourism policy formulation, the policy objective, and how the stated objectives are being realized while shedding light on their implications for sustainability, economic growth, and cultural preservation. The main objective of Nigeria's tourism policy is to protect and improve the nation's natural and cultural heritage. Many activities aimed at encouraging tourism development include planning, provision of infrastructure, taxation regime that supports tourism growth, education and training for tourism employees, marketing, legislation and regulation in order to protect and preserve tourist facilities as well as the country's natural resources, historical and cultural assets. The critical concern is the enforcement and effectiveness of regulations, specifically the probability of a policy successfully promoting sustainable and viable tourism development and management.
Aims: This paper therefore investigates the influence of tourism policies on the performance of heritage sites in Nigeria and the need for policy review for improved performance of Nigerian heritage sites.
Methodology: The qualitative research paradigm emerged from a comprehensive review of tourism policy literature in Nigeria. The examination of documents and research projects focused on various aspects of tourism policy planning and governance, policy formulation, policy objectives, and their implications for sustainability, economic growth, and natural/cultural heritage preservation. In the data analysis, the comprehensive review were presented with an interpretative narrative.
Results: The findings revealed that Nigeria's tourism policy seeks to empower the tourism industry and position it as a key driver of economic growth, job creation, and cultural heritage preservation. However, the policy's ability to achieve its goals optimally has been significantly hampered by lack of relevant mechanisms to measure overall levels of compliance, overreliance on petroleum resources, poor planning, and inadequate participation of relevant stakeholders in policy formulation, implementation, and monitoring.
Conclusion: Despite policies and frameworks, Nigeria's tourism sector, including cultural heritage sites, has failed to reach its goals, losing the economy numerous potential benefits. In order to address the current circumstances and ensure successful heritage site design, development, and management in Nigeria, there is an urgent need for revision of the country’s tourism policy objectives and adequate enforcement measures implemented to adapt to changing circumstances and priorities.
Copper‐Catalyzed Direct C Arylation of Heterocycles with Aryl Bromides: Discovery of Fluorescent Core Frameworks
Authors: Zhao Dongbing , Wang Wenhai , Yang Fei , Lan Jingbo , Yang Li , Gao Ge , You Jingsong 
Published: March 2009

AbstractDie Arylierung von Heterocyclen mit vielfältigen Arylbromiden beruht auf einer allgemeinen kupferkatalysierten C‐H‐Bindungsaktivierung (siehe Schema). Die hoch regioselektive Reaktion ist mit vielen funktionellen Gruppen verträglich. Die 8‐Arylxanthinprodukte fluoreszieren in verschiedenen Lösungsmitteln und sind aussichtsreich als Reagentien für die biologische Bildgebung.magnified image
A Ditopic Ion‐Pair Receptor Based on Stacked Nucleobase Quartets
Authors: van der Wijst Tushar , Fonseca Guerra Célia , Swart Marcel , Bickelhaupt F. Matthias , Lippert Bernhard 
Published: March 2009

AbstractPass the salt, please!State‐of‐the‐art computations indicate that the stacking complex of a guanine quartet and an adenine quartet (G4A4) can function as a potent ditopic receptor for NaCl in aqueous solution (see picture; Na+, Cl− yellow, O red, N blue, C black, H white).magnified image
Toward the identification of symptom patterns in people with fibromyalgia
Authors: Wilson Hilary D. , Robinson James P. , Turk Dennis C. 
Published: March 2009

AbstractObjectivePeople with fibromyalgia (FM) report a number of physical, cognitive, and psychological symptoms. The purpose of the current study was to determine whether people with FM differed based on the type and severity of symptoms, and if so, whether subgroups differ with respect to health care utilization, functional ability, and work status.MethodsSymptom, health care utilization, work, and physical data were available for 2,182 female responders to an Internet survey. Factor analysis was conducted on the physical and cognitive/psychological symptoms, and resulting factor scores were utilized in a cluster analysis to identify subgroups based on symptoms. Cluster groups were compared on a set of variables (e.g., health care utilization, coping).ResultsFactor analyses resulted in 3 symptom factor scores: musculoskeletal, non‐musculoskeletal, and cognitive/psychological symptoms. The optimal cluster solution to the cluster analysis revealed 4 clusters. Group 1 was high on all 3 symptom domains, group 2 was moderate on the 2 physical symptom domains and high on cognitive/psychological symptoms, group 3 was moderate on the 2 physical symptom domains and low on cognitive/psychological symptoms, and group 4 was low on all symptom domains. The more symptomatic groups reported the greatest amount of health care utilization and difficulty in coping with symptoms.ConclusionThe FM population is heterogeneous with regard to symptom reporting. Additional research is needed to better understand differential symptom experience among people with FM. Clarification of these differences may increase understanding of the mechanisms involved in FM and provide guidance for treatment decisions.
Physician ability to assess rheumatoid arthritis disease activity using an electronic medical record–based disease activity calculator
Authors: Collier Deborah S. , Grant Richard W. , Estey Greg , Surrao Dominic , Chueh Henry C. , Kay Jonathan 
Published: March 2009

AbstractObjectiveTo assess physicians' concordance with Disease Activity Score in 28 joints (DAS28) categories calculated by an electronic medical record (EMR)–embedded disease activity calculator, as well as attitudes toward this application.MethodsFifteen rheumatologists used the EMR‐embedded disease activity calculator to predict a rheumatoid arthritis (RA) DAS28 disease activity category at the time of each clinical encounter.ResultsPhysician‐predicted DAS28 disease activity categories ranged from high (>5.1, 15% of cohort, 66 of 429 patient visits) to moderate (>3.2–5.1, 21% of cohort, 90 of 429 patient visits) to low (2.6–3.2, 29% of cohort, 123 of 429 patient visits) to remission (<2.6, 35% of cohort, 150 of 429 patient visits). Overall concordance between calculated DAS28 results and physician‐predicted RA disease activity was 64%. Using either the physician‐predicted or the calculated DAS28 category as the gold standard, accuracy was greatest for patients in remission (75% and 88% accuracy, respectively) and those with high disease activity (68% and 79% accuracy, respectively), and less for patients with moderate (48% and 62% accuracy, respectively) or low disease activity (62% and 31% accuracy, respectively).ConclusionAccurate physician prediction of DAS28 remission and high disease activity categories, even without immediate availability of the erythrocyte sedimentation rate or the C‐reactive protein level at the time of the visit, may be used to guide quantitatively driven outpatient RA management.This article was published online on March 30, 2009. An error was subsequently identified in Figure 4. This notice is included in the online and print versions to indicate that both have been corrected.
Influence of preoperative patient education on the risk of dislocation after primary total hip arthroplasty
Authors: Lübbeke Anne , Suvà Domizio , Perneger Thomas , Hoffmeyer Pierre 
Published: March 2009

AbstractObjectiveDislocation is a well‐known complication after total hip arthroplasty (THA), and is the second‐highest cause of revision surgery. Our objective was to assess the effect of preoperative patient education on the occurrence of hip dislocation within 6 months after primary THA.MethodsBetween 1998 and 2007, we conducted a prospective cohort study at the Geneva University Hospital Department of Orthopaedic Surgery, including all primary THAs performed via an anterolateral transgluteal approach with the use of a 28‐mm diameter head. The preoperative education session was introduced in June 2002 and included advice on muscle strengthening exercises and postoperative restrictions of range of motion as a means of preventing dislocation. The main outcome was the incidence of dislocation within 6 months of surgery.ResultsA total of 597 patients who underwent 656 THAs between June 2002 and June 2007 participated in the education session, whereas 1,641 patients who underwent 1,945 procedures did not. Forty‐six dislocations occurred over the study period, 5 (0.8%) in participants and 41 (2.1%) in nonparticipants (absolute risk reduction 1.3%; 95% confidence interval [95% CI] 0.4, 2.3), with the time interval between surgery and dislocation being significantly shorter among participants (0.2 versus 1.2 months). Nonparticipants had a 2.8 times higher risk of dislocation than participants (unadjusted odds ratio [OR] 2.80; 95% CI 1.10, 7.13). Adjustment for age, sex, comorbidities, and prior surgery did not change the results (adjusted OR 2.79; 95% CI 1.09, 7.15).ConclusionOur findings suggest that participation in a preoperative patient education session may reduce the risk of dislocation within 6 months after THA.
Cerebral venous thrombosis in Behçet's disease
Authors: Saadoun D. , Wechsler B. , Resche‐Rigon M. , Trad S. , Le Thi Huong D. , Sbai A. , Dormont D. , Amoura Z. , Cacoub P. , Piette J. C. 
Published: March 2009

AbstractObjectiveTo analyze the clinical findings, treatment, outcome, and prevalence of cerebral venous thrombosis (CVT) in a large cohort of patients with Behçet's disease (BD) from a single center.MethodsWe reported a series of 64 consecutive patients with CVT who fulfilled the international criteria for BD. Multivariate analysis was performed to define factors that affect prognosis.ResultsAmong a cohort of 820 patients with BD, CVT was present in 64 (7.8%). Compared with BD patients without CVT, those with CVT had lower parenchymal central nervous system involvement (4.7% versus 28.7%; P = 0.0001) and higher extraneurologic vascular lesions (62.5% versus 38.8%; P = 0.03). Up to 90% of patients responded to anticoagulation therapy without severe hemorrhagic complications. Neither steroid nor immunosuppressant use provided better outcome. Severe visual loss due to optic atrophy was the main complication of CVT, being found in 15% of patients. In multivariate analysis, papilledema (odds ratio [OR] 7.1, 95% confidence interval [95% CI] 1.6–31.9) and concurrent prothrombotic risk factors (OR 4.6, 95% CI 1.1–20.2) were independently associated with the occurrence of sequelae. Factors associated with relapse of thrombosis were concurrent prothrombotic risk factors (hazard ratio [HR] 4.9, 95% CI 1.5–15.4) and a peripheral venous thrombosis (HR 2.8, 95% CI 0.7–10.5). After a mean ± SD followup of 8.2 ± 6.9 years, 4 deaths unrelated to CVT were noted.ConclusionCVT in patients with BD may result in serious neurologic outcomes. Anticoagulation represents a safe and effective therapy. Extensive investigation of prothrombotic disorders should be considered.
Combined oral contraceptive use and the risk of systemic lupus erythematosus
Authors: Bernier Marie‐odile , Mikaeloff Yann , Hudson Marie , SuissA Samy 
Published: March 2009

AbstractObjectiveTo assess whether the risk of incident systemic lupus erythematosus (SLE) is associated with the use of combined oral contraceptives (COCs), because studies of the link between exogenous hormonal exposure and the risk of SLE have produced conflicting results.MethodsWe conducted a population‐based nested case–control study among women ages 18–45 years, using the UK's General Practice Research Database. All incident cases of SLE from 1994–2004 (n = 786) were identified in the database and matched with up to 10 controls (n = 7,817) among women without SLE at the time of the case's diagnosis.ResultsThe adjusted rate ratio (RR) of incident SLE associated with any use of COC was 1.19 (95% confidence interval [95% CI] 0.98–1.45), whereas with current use it was 1.54 (95% CI 1.15–2.07). The rate was particularly increased in current users who had only recently started COC use (RR 2.52, 95% CI 1.14–5.57) compared with longer‐term current users (RR 1.45, 95% CI 1.06–1.99). The risk appeared to be particularly elevated with current exposure to first‐ or second‐generation contraceptives (RR 1.65, 95% CI 1.20–2.26), and increasing with the dose of ethinyl estradiol (RR 1.42, 1.63, and 2.92 for ≤30 μg, 31–49 μg, and 50 μg, respectively).ConclusionThe use of COCs is associated with an increased risk of SLE. This risk is particularly elevated in women who recently started contraceptive use, suggesting an acute effect in a small subgroup of susceptible women.
Golimumab, a new human tumor necrosis factor α antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: Twenty‐four–week efficacy and safety results of a randomized, placebo‐controlled study
Authors: Kavanaugh Arthur , McInnes Iain , Mease Philip , Krueger Gerald G. , Gladman Dafna , Gomez‐Reino Juan , Papp Kim , Zrubek Julie , Mudivarthy Surekha , Mack Michael , Visvanathan Sudha , Beutler Anna 
Published: March 2009

AbstractObjectiveTo assess the efficacy and safety of golimumab in patients with active psoriatic arthritis (PsA).MethodsAdult patients with PsA who had at least 3 swollen and 3 tender joints and active psoriasis were randomly assigned to receive subcutaneous injections of placebo (n = 113), golimumab 50 mg (n = 146), or golimumab 100 mg (n = 146) every 4 weeks through week 20. Efficacy assessments through week 24 included the American College of Rheumatology 20% improvement criteria (ACR20), the Psoriasis Area and Severity Index (PASI) in patients in whom at least 3% of the body surface area was affected by psoriasis at baseline, the Short Form 36 Health Survey (SF‐36), the disability index of the Health Assessment Questionnaire (HAQ), the Nail Psoriasis Severity Index (NAPSI), the physician's global assessment of psoriatic nail disease, and enthesitis (using the PsA‐modified Maastricht Ankylosing Spondylitis Enthesitis Score [MASES] index).ResultsAt week 14, 48% of all patients receiving golimumab, 51% of patients receiving golimumab 50 mg, and 45% of patients receiving golimumab 100 mg achieved an ACR20 response (the primary end point), compared with 9% of patients receiving placebo (P < 0.001 for all comparisons). Among the 74% of patients in whom at least 3% of the body surface area was affected by psoriasis at baseline, 40% of those in the golimumab 50 mg group and 58% of those in the golimumab 100 mg group had at least 75% improvement in the PASI at week 14 (major secondary end point), compared with 3% of placebo‐treated patients (P < 0.001 for both doses). Significant improvement was observed for other major secondary end points (the HAQ and the SF‐36), the NAPSI, the physician's global assessment of psoriatric nail disease, and the PsA‐modified MASES index in each golimumab group compared with placebo. This efficacy was maintained through week 24. Golimumab was generally well tolerated.ConclusionTreatment with golimumab at doses of 50 mg and 100 mg significantly improved active PsA and associated skin and nail psoriasis through week 24.
Facile Synthesis and Systematic Investigations of a Series of Novel Bent‐Shaped Two‐Photon Absorption Chromophores Based on Pyrimidine
Authors: Li Lin , Tian Yu‐Peng , Yang Jia‐Xiang , Sun Ping‐Ping , Wu Jie‐Ying , Zhou Hong‐Ping , Zhang Sheng‐Yi , Jin Bao‐Kang , Xing Xiao‐Juan , Wang Chuan‐Kui , Li Ming , Cheng Guang‐Hua , Tang Huo‐Hong , Huang Wen‐Hao , Tao Xu‐Tang , Jiang Min‐Hua 
Published: March 2009

AbstractMark us bent! The synthesis, structure, and single‐ and two‐photon spectroscopic properties of a series of pyrimidine‐based (bent‐shaped) molecules are reported. These allow structure‐property relationships and guidelines for both the development and application of TPA compounds to be derived.magnified imageThe synthesis, structure, and single‐ and two‐photon spectroscopic properties of a series of pyrimidine‐based (bent‐shaped) molecules are reported. All these stable heterocyclic compounds are fully characterized, and exhibit intense single‐ and two‐photon excited fluorescence (SPEF and TPEF) over a wide spectral range from blue to red, with the spectral peak position of the SPEF being basically the same as that of the TPEF. The well‐conjugated π‐systems, observed from the crystal structure, indicate the charge transfer feature of the ground state. Meanwhile, the theoretical and experimental studies indicate that the charge transfer from donor to acceptor is greatly enhanced in the excited states and the different substituted donor groups on the pyrimidine have a large effect on the optical and electrochemical properties. Based on typical structure data and comprehensive spectral data, the following structure‐property relationships can be determined: for such bent‐shaped chromophores, the absorption and the fluorescence wavelength maximum of the SPEF and TPEF, and two‐photon absorption cross sections show a similar trend with increasing electron‐donating strength of the corresponding terminal group and the number of branches, while the average bond lengths of the π‐linkage and HOMO–LUMO energy levels show an inverse trend. Experimental data and theoretical calculation provide a coherent picture. With these findings, bent‐shaped quadrupolar chromophores combining peak TPA cross sections (up to 2280 GM), broad TPA bands throughout the whole 700–900 nm range, and high fluorescence quantum yields could, thus, be obtained. Such compounds are of particular interest for TPEF microscopy, as well as optical data storage in the visible and NIR regions. A data recording experiment proved the potential application of these materials.