bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Studies on Novel Synthetic Methodologies. Part 226. Organic Reactions in Water: A Distinct Approach for the Synthesis of Quinoline Derivatives Starting Directly from Nitroarenes.
Authors: Das Biswanath , Jangili Paramesh , Kashanna Jajula , Kumar Rathod Aravind 
Published: January 2012

AbstractThe biologically interesting quinoline skeleton is readily available in good to excellent yield and functional groups including halogens remain unaffected.
ChemInform Abstract: Design and Synthesis of Novel Polycycles Based on the 3H‐Pyrrolo/6,7‐dihydropyrido[1,2‐a]indole Scaffold as Templates for Pharmaceutical Development.
Authors: Derudas Marco , Pala Nicolino , Sanna Vanna , Dallocchio Roberto , Dessi Alessandro , Roggio Anna Maria , Sechi Mario 
Published: January 2012

AbstractThe DNA‐binding properties of (VIa) are investigated by viscometric titration, revealing a potential intercalating activity.
ChemInform Abstract: Synthesis, Characterization and Antibacterial Activity of Benzimidazole Derivatives Carrying Quinoline Moiety.
Authors: Gowda Janardhana , Khader A. M. A. , Kalluraya Balakrishna , Hidayathulla Syed 
Published: January 2012

AbstractA series of 2‐(1H‐benzimidazol‐2‐yl)‐substituted thienoquinolines (III) is obtained in a one‐step process in which benzimidazole (II) undergoes a nucleophilic substitution and cyclization with 2‐chloroquinoline‐3‐carbaldehydes (I).
ChemInform Abstract: Convenient Synthesis of 5‐Aryl(alkyl)sulfanyl‐1,10‐phenanthrolines from 5,6‐Epoxy‐5,6‐dihydro‐1,10‐phenanthroline, and Their Activity Towards Fungal β‐D‐Glycosidases.
Authors: Dotsenko Irina A. , Curtis Matthew , Samoshina Nataliya M. , Samoshin Vyacheslav V. 
Published: January 2012

AbstractBase‐mediated reaction of epoxydihydrophenanthroline (I) with various thiols proceeds with subsequent dehydration to give title organylsulfanylphenanthrolines, e.g. (III), (V), (VII), in good yields.
ChemInform Abstract: Immobilized Cu(I) on Organic—Inorganic Hybrid Material: An Effective and Reusable Catalyst for Biginelli Reaction.
Authors: Zhang Xiao L. , Wang Min , Wang Lei 
Published: January 2012

AbstractA functionalized silica‐supported Cu(I) complex efficiently catalyzes the Biginelli reaction of aromatic aldehydes, β‐keto esters and urea or thiourea.
ChemInform Abstract: Three‐Component Synthesis of Spiro[indoline‐3,5′‐pyrimido[4,5‐b]quinoline]‐triones in Water.
Authors: Jadidi Khosrow , Ghahremanzadeh Ramin , Mirzaei Peiman , Bazgir Ayoob 
Published: January 2012

AbstractThe stable title compounds (IV) are synthesized via an efficient, simple, and convenient one‐pot method, which includes the use of an inexpensive catalyst and an easy work‐up.
ChemInform Abstract: Regioselective Synthesis and Characterization of New 3‐Aryl‐7‐trifluoromethyl‐[1,2,4]triazolo[4,3‐a]pyrimidines.
Authors: Zanatta Nilo , Amaral Simone S. , dos Santos Josiane M. , Fernandes Liana da S. , Bonacorso Helio G. , Martins Marcos A. P. 
Published: January 2012

AbstractA simple method for the synthesis of the title compounds (II) is presented.
ChemInform Abstract: Synthesis and Structure of a New Heterocyclic System — 7,8‐Dihydroimidazo[1,2‐c][1,3]thiazolo[4,5‐e]pyrimidine.
Authors: Kozachenko A. P. , Shablykin O. V. , Vasilenko A. N. , Chernega A. N. , Brovarets V. S. 
Published: January 2012

AbstractThe preparation of 7‐thioxoimidazo[1,2‐c]pyrimidines (III) and their regioselective intramolecular condensation furnishing products (IV) are described for the first time.
ChemInform Abstract: Efficient and Original Microwave‐Assisted Suzuki—Miyaura Cross‐Coupling Reaction in the 4H‐Pyrido[1,2‐a]pyrimidin‐4‐one Series.
Authors: Kabri Youssef , Crozet Maxime D. , Szabo Remi , Vanelle Patrice 
Published: January 2012

AbstractA generally operating procedure is developed for the Pd‐catalyzed coupling of boronic acids with 3‐iodo substituted pyrido[1,2‐a]pyrimidin‐4‐one (I).
ChemInform Abstract: A Comprehensive Study of the Heterocyclizations of N‐Arylmaleimides and 6‐Aminouracils.
Authors: Rudenko Roman V. , Komykhov Sergey A. , Desenko Sergey M. , Sen'ko Yulia V. , Shishkin Oleg V. , Konovalova Irina S. , Shishkina Svetlana V. , Chebanov Valentin A. 
Published: January 2012

AbstractA simple procedure in suitable solvents allows the selective synthesis of pyrimidopyridone products.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling Reactions of Halo Derivatives of 4H‐Pyrido[1,2‐a]pyrimidin‐4‐ones.
Authors: Molnar Annamaria , Kapros Anita , Parkanyi Laszlo , Mucsi Zoltan , Vlad Gabor , Hermecz Istvan 
Published: January 2012

AbstractThe reactivity of chloro, bromo, and iodo substituents at different positions on the pyridopyrimidinone skeleton in Suzuki—Miyaura cross‐coupling reactions is investigated.
ChemInform Abstract: Microwave‐Assisted Synthesis of 2,6‐Substituted Aromatic Aminopurine Derivatives.
Authors: Lu Hong‐Fei , Zhang Liang‐Ze , Wu Ding‐Ming , Zhou Jun‐Tao 
Published: January 2012

AbstractThe conversion of (IV) to (V) can also be conducted in the presence of HCl or AlCl3.
ChemInform Abstract: Synthesis of Pyrrolo[1,2‐a]pyrazines and Pyrazino[1,2‐a]indoles by Curtius Reaction in Morita—Baylis—Hillman Derivatives.
Authors: Nayak Maloy , Pandey Garima , Batra Sanjay 
Published: January 2012

AbstractKey feature of the synthesis of title pyrrolopyrazine scaffolds is the Curtius reaction of formylpyrrolyl‐substituted acids to generate an isocyanate, which is directly cyclized in the presence of formic acid [cf.
ChemInform Abstract: Synthesis of 2,3‐Dihydro‐6H‐1‐oxa‐3a‐aza‐phenalene and Its Benzo/Hetero‐Fused Analogue.
Authors: Mizar Pushpak , Hormi Mecadon , Rajbangshi Mantu , Myrboh Bekington 
Published: January 2012

AbstractThe title compounds, e.g. (VIII) and (XIV), are prepared using benzoxazines and α‐oxoketene dithio‐acetals.
ChemInform Abstract: Catalytic Asymmetric Pictet—Spengler‐Type Reaction for the Synthesis of Optically Active Indolo[3,4‐cd][1]benzazepines.
Authors: Cheng Dao‐Juan , Wu Hai‐Bian , Tian Shi‐Kai 
Published: January 2012

AbstractCompared to the conventional process, the aldehyde substrates are replaced by an imine.
ChemInform Abstract: Towards High Efficiency Solid Emitters with Aggregation‐Induced Emission and Electron‐Transport Characteristics
Authors: Yuan Wang Zhang , Chen Shuming , Lam Jacky W. Y. , Deng Chunmei , Lu Ping , Sung Herman H.‐Y. , Williams Ian D. , Kwok Hoi Sing , Zhang Yongming , Tang Ben Zhong 
Published: January 2012

Abstractsynthesis and characterization of the new bluish‐green emitter (I) with aggregation‐induced emission activity and excellent electron‐transport properties
ChemInform Abstract: Organocatalyzed Synthesis of α‐(Substituted Methyl)vinylphosphonates.
Authors: Garzon Cecile , Attolini Mireille , Maffei Michel 
Published: January 2012

AbstractDABCO‐promoted substitution of the O‐Boc moiety in the vinylphosphonate (I) with N‐ or C‐nucleophiles permits the efficient synthesis of the synthetically important title compounds.
ChemInform Abstract: Synthesis of a New Class of Phosphinic Acids: Synthesis of Novel Four‐Membered Cyclic Oxaphosphetanes by Intramolecular Mitsunobu Reaction of Bis(α‐hydroxyalkyl)phosphinic Acids.
Authors: Kaboudin Babak , Haghighat Hamideh , Yokomatsu Tsutomu 
Published: January 2012

AbstractThe reaction is stereoselective and successful, if aryl‐substituted substrates are used.
ChemInform Abstract: Quinidine Thiourea‐Catalyzed Enantioselective Synthesis of β‐Nitrophosphonates: Beneficial Effects of Molecular Sieves.
Authors: Abbaraju Santhi , Bhanushali Mayur , Zhao Cong‐Gui 
Published: January 2012

AbstractThe quinidine‐thiourea‐catalyzed asymmetric Michael addition of diphenylphosphite towards β‐nitroolefins is significantly improved by filtration of diphenylphosphite through molecular sieves and addition of molecular sieves to the reaction mixture.
ChemInform Abstract: Selectivity in Reduction of Natural Furanoheliangolides with Stryker′s Reagent.
Authors: Sass Daiane C. , Heleno Vladimir C. G. , Morais Gustavo O. , Lopes Joao L. C. , Lopes Norberto P. , Constantino Mauricio G. 
Published: January 2012

AbstractNatural sesquiterpene lactones (I) and (IV), and the ether derivatives (VII) and (X) are chemoselectively reduced through a biomimetic pathway affording eremantholides (II) and (V), and the corresponding derivatives (VIII) and (XI).
ChemInform Abstract: Unusual Behavior of Methylidenetriphenylphosphorane in Reactions with Seven‐Membered Lactols.
Authors: Ishmuratov G. Yu. , Vydrina V. A. , Yakovleva M. P. , Valeeva E. F. , Muslukhov R. R. , Tolstikov G. A. 
Published: January 2012

AbstractMethylidenetriphenylphosphorane can act as reducing agent in reactions with seven‐membered lactols or their aluminates furnishing diols such as (II).
ChemInform Abstract: A Facile Cu(I)/BINAP‐Catalyzed Asymmetric Approach to Functionalized Pyroglutamate Derivatives Bearing a Unique Quaternary Stereogenic Center.
Authors: Teng Huai‐Long , Luo Fei‐Long , Tao Hai‐Yan , Wang Chun‐Jiang 
Published: January 2012

AbstractThe tandem Micheal addition—elimination [ ‐< conditions A)] is followed by deprotection [‐< conditions B)] and lactamization [‐< conditions C)].
ChemInform Abstract: Synthesis and Antimicrobial Activity of New C‐Furyl Glycosides Bearing Substituted 1,3,4‐Oxadiazoles.
Authors: El‐Sayed Wael A. , Abbas Hebat‐Allah S. , Mohamed Ashraf M. , Abdel‐Rahman Adel A.‐H. 
Published: January 2012

AbstractAll compounds are screened for their antimicrobial activity against Pseudomonas sp., B.
ChemInform Abstract: Synthesis of the ABH Rings of Ecteinascidin 597 Using a Connective Pummerer‐Type Cyclization.
Authors: Smith Laura H. S. , Nguyen Trung Thanh , Sneddon Helen F. , Procter David J. 
Published: January 2012

AbstractA connective Pummerer‐type cyclization involving a N‐protected glyoxamide (I) and a cysteine derivative (II) is applied to an asymmetric synthesis of the protected ABH rings of ecteinascidin 597.
ChemInform Abstract: Adventure in Asymmetric Hydrogenation: Synthesis of Chiral Phosphorus Ligands and Asymmetric Hydrogenation of Heteroaromatics
Authors: Hu Xiang‐Ping , Wang Duo‐Sheng , Yu Chang‐Bin , Zhou Yong‐Gui , Zheng Zhuo 
Published: January 2012

AbstractReview: 129 refs.
Remarkable enantioselective α‐amination in 1‐phenyl‐2‐(n‐alkylamino)‐1‐propanol
Authors: Kumar Borkatte N. Hitesh , Murugesan Velayutham , Prakasam Tangirala , Srinivasan Pathangi S. , Ramana Devalla V. 
Published: January 2012

Abstract(1R,2R)‐1‐Phenyl‐1‐alkyl/arylamino‐2‐(N‐alkylamino)propane hydrochloride salts have been synthesized with high degree of enantiomeric purity from (1S,2R)‐(+)‐1‐phenyl‐2‐(N‐alkylamino)‐1‐propanol through the corresponding chloro derivatives. This reaction sequence involves three inversions with overall inversion of configuration at C‐1. Chirality, 2012. © 2012 Wiley Periodicals, Inc.
Reductive Dechlorination of PCBs Using Photocatalyzed UV Light
Authors: Ghosh Jyoti P. , Achari Gopal , Langford Cooper H. 
Published: January 2012

AbstractFeasibility of photocatalytic dechlorination of PCB‐138 and Aroclor‐1254 using platinum loaded TiO2 (P25) in an alkaline 2‐propanol medium has been investigated. Experiments were conducted in batch mode using a Rayonet photo‐reactor under aerated and deaerated conditions with black lamps emitting around 350 nm as light source. Two forms of platinum deposition were investigated: Photochemically loaded P25 as well as addition of potassium hexachloroplatinate into the reaction medium. Partial dechlorination of PCBs was observed after 7 h of irradiation with pure TiO2 as catalyst when the reaction vessel was kept open to air. Complete dechlorination was observed after 5 h of irradiation in a deaerated environment. Enhanced photocatalytic efficiency was observed when platinum deposited P25 was used as catalyst, with the best result being obtained when aqueous potassium hexachloroplatinate was added into the reaction medium. Lower potassium hexachloroplatinate concentration (0.1 mM) yielded better performance.
Lentil Straw: A Novel Adsorbent for Removing of Hazardous Dye – Sorption Behavior Studies
Authors: Çelekli Abuzer , Tanrıverdi Barış , Bozkurt Hüseyin 
Published: January 2012

AbstractSorption behavior of Lanaset Red (LR) G on lentil straw (LS) was studied as a function of particle size, adsorbent dose, initial pH value, initial dye concentration, and contact time. Sorption kinetics data was well described by logistic model. Modified logistic equation can be used to explain effects of initial dye concentrations and contact time on the sorption of LR G with high R2 value. Freundlich model was found to be excellent in representing the equilibrium data. Thermodynamic parameters like free energy (ΔG0), enthalpy (ΔH0), and entropy (ΔS0) were calculated by the use of Langmuir constant. Thermodynamic data showed that the sorption processes were spontaneous and endothermic in nature. Desorption process suggested that strong binding and weak interactions could be formed between adsorbent surface and dye molecules. Results revealed that LS has a remarkable potential for the sorption of LR G.
A snapshot of smokers after lung and colorectal cancer diagnosis
Authors: Park Elyse R. , Japuntich Sandra J. , Rigotti Nancy A. , Traeger Lara , He Yulei , Wallace Robert B. , Malin Jennifer L. , Zallen Jennifer P. , Keating Nancy L. 
Published: January 2012

AbstractBACKGROUND:Continued smoking after a cancer diagnosis may adversely affect treatment effectiveness, subsequent cancer risk, and survival. The prevalence of continued smoking after cancer diagnosis is understudied.METHODS:In the multi‐regional Cancer Care Outcomes Research and Surveillance cohort (lung cancer [N = 2456], colorectal cancer [N = 3063]), the authors examined smoking rates at diagnosis and 5 months after diagnosis and also study factors associated with continued smoking.RESULTS:Overall, 90.2% of patients with lung cancer and 54.8% of patients with colorectal cancer reported ever smoking. At diagnosis, 38.7% of patients with lung cancer and 13.7% of patients with colorectal cancer were smoking; whereas, 5 months after diagnosis, 14.2% of patients with lung cancer and 9.0% of patients with colorectal cancer were smoking. Factors that were associated independently with continued smoking among patients with nonmetastatic lung cancer were coverage by Medicare, other public/unspecified insurance, not receiving chemotherapy, not undergoing surgery, prior cardiovascular disease, lower body mass index, lower emotional support, and higher daily ever‐smoking rates (all P < .05). Factors that were associated independently with continued smoking among patients with nonmetastatic colorectal cancer were male sex, high school education, being uninsured, not undergoing surgery, and higher daily ever‐smoking rates (all P < .05).CONCLUSIONS:After diagnosis, a substantial minority of patients with lung and colorectal cancers continued smoking. Patients with lung cancer had higher rates of smoking at diagnosis and after diagnosis; whereas patients with colorectal cancer were less likely to quit smoking after diagnosis. Factors that were associated with continued smoking differed between lung and colorectal cancer patients. Future smoking‐cessation efforts should examine differences by cancer type, particularly when comparing cancers for which smoking is a well established risk factor versus cancers for which it is not. Cancer 2012;118: 3153–64. © 2012 American Cancer Society.
New Biobased High Functionality Polyols and Their Use in Polyurethane Coatings
Authors: Pan Xiao , Webster Dean C. 
Published: January 2012

AbstractHigh‐functionality polyols for application in polyurethanes (PUs) were prepared by epoxide ring‐opening reactions from epoxidized sucrose esters of soybean oil—epoxidized sucrose soyates—in which secondary hydroxyl groups were generated from epoxides on fatty acid chains. Ester polyols were prepared by using a base‐catalyzed acid–epoxy reaction with carboxylic acids (e.g., acetic acid); ether polyols were prepared by using an acid‐catalyzed alcohol–epoxy reaction with monoalcohols (e.g., methanol). The polyols were characterized by using gel permeation chromatography, FTIR spectroscopy, 1H NMR spectroscopy, differential scanning calorimetry (DSC), and viscosity measurements. PU thermosets were prepared by using aliphatic polyisocyanates based on isophorone diisocyanate and hexamethylene diisocyanate. The properties of the PUs were studied by performing tensile testing, dynamic mechanical analysis, DSC, and thermogravimetric analysis. The properties of PU coatings on steel substrates were evaluated by using ASTM methods to determine coating hardness, adhesion, solvent resistance, and ductility. Compared to a soy triglyceride polyol, sucrose soyate polyols provide greater hardness and range of cross‐link density to PU thermosets because of the unique structure of these macromolecules: well‐defined compact structures with a rigid sucrose core coupled with high hydroxyl group functionality.
Priorities in offloading the diabetic foot
Authors: Bus Sicco A. 
Published: January 2012

SummaryBiomechanical factors play an important role in diabetic foot disease. Reducing high foot pressures (i.e. offloading) is one of the main goals in healing and preventing foot ulceration. Evidence‐based guidelines show the strong association between the efficacy to offload the foot and clinical outcome. However, several aspects related to offloading are underexposed. First, in the management of foot complications, offloading is mostly studied as a single entity, whereas it should be analysed in a broader perspective of contributing factors to better predict clinical outcome. This includes assessment of patient behavioural factors such as type and intensity of daily physical activity and adherence to prescribed treatment. Second, a large gap exists between evidence‐based recommendations and clinical practice in the use of offloading for ulcer treatment, and this gap needs to be bridged. Possible ways to achieve this are discussed in this article. Third, our knowledge about the efficacy and role of offloading in treating complicated and non‐plantar neuropathic foot ulcers needs to be expanded because these ulcers currently dominate presentation in multidisciplinary foot practice. Finally, foot ulcer prevention is underexposed when compared with ulcer treatment. Prevention requires a larger focus, in particular regarding the efficacy of therapeutic footwear and its relative role in comparison with other preventative strategies. These priorities need the attention of clinicians, scientists and professional societies to improve our understanding of offloading and to improve clinical outcome in the management of the diabetic foot. Copyright © 2012 John Wiley & Sons, Ltd.
Negative pressure therapy: theory and practice
Authors: Schintler M. V. 
Published: January 2012

SummaryNegative pressure (wound) therapy, synonymous with topical negative pressure or vacuum therapy mainly cited as branded VAC® (vacuum‐assisted closure) therapy, is a mode of therapy used to encourage wound healing. It is used both as primary treatment of chronic and complex wounds and as an adjunct for temporary closure and wound bed preparation preceding surgical procedures such as skin grafts and flap surgery. The device has come into wide and successful use, although the physiological basis of its effect is not yet fully understood, and with a delay, increasingly evidence‐based data become available. A meta‐analysis was made of peer‐reviewed publications (PubMed–Medline) chosen on the basis of inclusion of the terms randomized clinical trial, vacuum‐assisted closure, and topical negative pressure. Scientific data were evaluated from experimental animal studies, randomized clinical trials, observations of clinical applications, and case reports on all known effects of VAC therapy. Systematic analysis of the data shows efficacy concerning induction of wound healing mechanisms, especially in the early stage. Increased perfusion can be considered proven. Data analysis shows positive efficacy for treatment of infection. Although this therapy appears effective and its superiority to conventional techniques has been demonstrated, there are still some critical votes concerning efficacy. Because its mechanisms of action remain unclear, and because there is still some gap between evidence‐based data and the excellent clinical results, further prospective, randomized, blinded studies are needed. Even so, we conclude that vacuum therapy, used when indicated and especially by experienced surgeons, is an excellent tool to support wound healing. Copyright © 2012 John Wiley & Sons, Ltd.
Choosing life or limb. Improving survival in the multi‐complex diabetic foot patient
Authors: Game Fran 
Published: January 2012

SummaryOver two decades ago, the St. Vincent Declaration set a 50% reduction of lower‐limb amputations as a principal target for patients with diabetes. During this time, enormous strides have been taken in our understanding of diabetic foot disease, the complexities of wound healing and the organization of care to prevent what is one of the most feared complications of the disease. Despite this, we are aware that worldwide, we have not achieved the target set in 1989, with current estimations being that a limb is lost to diabetes somewhere in the world every 30 s.However, it has to be remembered that amputation is a treatment and not a disease, and it is indeed a treatment usually prescribed at the end of a long chronic illness. It is well known that patients whose disease is severe enough for amputation to be considered frequently have other complications of their diabetes, cardiovascular and peripheral vascular diseases and end‐stage renal disease, in particular. The life expectancy of the patients is therefore frequently reduced, and their functional status poor even prior to the intervention of surgeons. Just as the functional status of the patients is often a contra‐indication to other disease treatments, chemotherapy for some cancers, for example, then we should be considering carefully whether we should be removing limbs from patients whose functional and medical status will not improve significantly as a result. Equally, there may be patients who may benefit from an early amputation and ambulation with a prosthesis. Copyright © 2012 John Wiley & Sons, Ltd.