bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Beta vulgaris Essential Oils Against Potato Dry Rot Disease and Deoxynivalenol (DON) Mycotoxin
Authors: Zöngür Alper 
Published: June 2024

AbstractPotato dry rot is a global problem caused by Fusarium species. Symptoms of dry rot include wrinkled brown to black patches of tissue. Fusarium spp. infection in potato tubers results in the formation of mycotoxins. Fungi that cause dry rot are commonly Fusarium sambucinum and Fusarium solani. This article was made to determine the effect of the essential oils of the Beta vulagaris plant on Fusarium species, which is the causative agent of dry rot in potatoes. In the study, Beta vulgaris plant essential oil content was determined by Gas Chromatography (GC–MC). In addition, the amount of deoxynivalenol (DON) mycotoxin produced by Fusarium species was determined by enzyme-linked immunosorbent assay (ELISA) analyses. Inhibition rates of these essential oils (1, 5, 10, 20, 50, 100, 250, 500, 1000 µl) on Fusarium sambicunum (1.3, 3.0, 5.2, 7.3, 9.1, 12.7, 22.3, 27.1, 29.1%) were found. Similarly, inhibition rates on Fusarium solani (1.1, 2.8, 4.3, 6.7, 8.8, 10.5, 19.4, 24.7, 27.3%) were found. In addition, the results showed that the amount of deoxynivalenol DON in 25 potato tubers ranged from 44.1–172.6 ppb. Infections of potato tubers caused by certain Fusarium species are typically accompanied by mycotoxin production, thus posing a potential risk to human health and food safety. In this study, it was determined that the essential oils of Beta vulgaris plant were effective against Fusarium spp., which are the cause of dry rot disease that may occur in potatoes.
Self-supervised learning for classifying paranasal anomalies in the maxillary sinus
Authors: Bhattacharya Debayan , Behrendt Finn , Becker Benjamin Tobias , Maack Lennart , Beyersdorff Dirk , Petersen Elina , Petersen Marvin , Cheng Bastian , Eggert Dennis , Betz Christian , Hoffmann Anna Sophie , Schlaefer Alexander 
Published: June 2024

Abstract
Purpose
Paranasal anomalies, frequently identified in routine radiological screenings, exhibit diverse morphological characteristics. Due to the diversity of anomalies, supervised learning methods require large labelled dataset exhibiting diverse anomaly morphology. Self-supervised learning (SSL) can be used to learn representations from unlabelled data. However, there are no SSL methods designed for the downstream task of classifying paranasal anomalies in the maxillary sinus (MS).

Methods
Our approach uses a 3D convolutional autoencoder (CAE) trained in an unsupervised anomaly detection (UAD) framework. Initially, we train the 3D CAE to reduce reconstruction errors when reconstructing normal maxillary sinus (MS) image. Then, this CAE is applied to an unlabelled dataset to generate coarse anomaly locations by creating residual MS images. Following this, a 3D convolutional neural network (CNN) reconstructs these residual images, which forms our SSL task. Lastly, we fine-tune the encoder part of the 3D CNN on a labelled dataset of normal and anomalous MS images.

Results
The proposed SSL technique exhibits superior performance compared to existing generic self-supervised methods, especially in scenarios with limited annotated data. When trained on just 10% of the annotated dataset, our method achieves an area under the precision-recall curve (AUPRC) of 0.79 for the downstream classification task. This performance surpasses other methods, with BYOL attaining an AUPRC of 0.75, SimSiam at 0.74, SimCLR at 0.73 and masked autoencoding using SparK at 0.75.

Conclusion
A self-supervised learning approach that inherently focuses on localizing paranasal anomalies proves to be advantageous, particularly when the subsequent task involves differentiating normal from anomalous maxillary sinuses. Access our code at https://github.com/mtec-tuhh/self-supervised-paranasal-anomaly.
Clinical Practice Guidelines of the Latin American Federation of Endocrinology for the use of vitamin D in the maintenance of bone health: recommendations for the Latin American context
Authors: Gómez Oscar , Campusano Claudia , Cerdas-P Sonia , Mendoza Beatriz , Páez-Talero Amanda , de la Peña-Rodríguez María Pilar , Reza-Albarrán Alfredo Adolfo , Rueda-Plata Pedro Nel 
Published: June 2024

Abstract
Introduction
These guidelines aim to provide evidence-based recommendations for the supplementation of Vitamin D in maintaining bone health. An unmet need persists in Latin American regarding the availability of clinical and real-world data for rationalizing the use of vitamin D supplementation. The objective of these guidelines is to establish clear and practical recommendations for healthcare practitioners from Latin American countries to address Vitamin D insufficiency in clinical practice.

Methods
The guidelines were developed according to the GRADE-ADOLOPMENT methodology for the adaptation or adoption of CPGs or evidence-based recommendations. A search for high quality CPGs was complemented through a comprehensive review of recent literature, including randomized controlled trials, observational studies, and systematic reviews evaluating the effects of Vitamin D supplementation on bone health. The evidence to decision framework proposed by the GRADE Working Group was implemented by a panel of experts in endocrinology, bone health, and clinical research.

Results
The guidelines recommend Vitamin D supplementation for individuals aged 18 and above, considering various populations, including healthy adults, individuals with osteopenia, osteoporosis patients, and institutionalized older adults. These recommendations offer dosing regimens depending on an individualized treatment plan, and monitoring intervals of serum 25-hydroxyvitamin D levels and adjustments based on individual results.

Discussion
The guidelines highlight the role of Vitamin D in bone health and propose a standardized approach for healthcare practitioners to address Vitamin D insufficiency across Latin America. The panel underscored the necessity for generating local data and stressed the importance of considering regional geography, social dynamics, and cultural specificities when implementing these guidelines.
A Functional Coefficients Version of a Generalized Orr–Sherby–Dorn Creep Model: An Application to 2.25Cr–1Mo Steel
Authors: Evans M. 
Published: June 2024

AbstractIt is important to be able to predict the creep life of materials used in power plants. This paper illustrates the inadequacies of the Orr–Sherby–Dorn (OSD) creep model in achieving this aim for 2.25Cr–1Mo steel. This failure is explained in terms of non-constant model parameters—which in turn is the result of changing creep mechanisms. The paper introduces a semi-parametric estimation procedure for a variant of the OSD model (a structural coefficients version) that can be used to deal with such changing creep mechanisms while maintaining the structure of the model and consequently producing more reliable long-term predictions compared to the unmodified OSD model and the recently introduced LOESS technique. For 2.25Cr–1Mo steel, it was found that the model parameters varied in line with changing creep mechanisms, but in a modified way compared to that already suggested in the literature for this material. The models used suggested that with diminishing stress and increasing temperature, dislocation creep within the crystal structure morphs into grain boundary dislocation motion and finally Nabarro-Herring creep.
The Effect of Static Recrystallisation of Parent Austenite on the Lath Martensite Intervariant Boundary Network
Authors: Mirzaei Ahmad , Hodgson Peter D. , Ma Xiang , Tari Vahid , Vahid Alireza , Beladi Hossein 
Published: June 2024

AbstractThe current study investigated the effect of static recrystallisation (SRX) of parent austenite microstructure on the lath martensite intervariant boundary network. In general, the misorientation angle distribution of lath martensite exhibited a bimodal distribution in the range of 10–22 deg and 47–60 deg for all thermomechanical conditions, closely matching the misorientations expected from the ideal Kurdjumov-Sachs orientation relationship. Nevertheless, the population of 60 deg misorientation angle initially reduced with the extent of softening up to 50 pct beyond which it progressively increased to a maximum in the fully recrystallised condition. This was closely consistent with the trend noticed for the 60 deg/[110] intervariant boundaries having twist character. This was explained through the distinct variant selection mechanism occurring due to the change in the parent austenite grain characteristics (i.e., size and deformed state) upon static recrystallisation. The recrystallisation initially led to the formation of fine dislocation-free parent austenite grains up to 50 pct softening, promoting a 4-variant (V1V2V3V4) clustering arrangement to decrease the strain related to the martensite transformation. In turn, this promoted the formation of symmetric tilt 60 deg/$$\left[ {11\overline{1}} \right]$$

11

1
¯

intervariant boundaries, which ultimately reduced the 60 deg/$$\left[ {110} \right]$$

110

boundaries. Further softening, accompanied with the growth and/or coalescence of parent austenite grains, altered the variant clustering to a 3-variant arrangement (V1V3V5) and the increase in 60 deg/$$\left[ {110} \right]$$

110

twist intervariant boundaries. Indeed, the martensite boundary network was largely controlled by the SRX parent austenite characteristics (i.e., size), which can be controlled to enhance the materials performance for a given application.
Subclinical hypothyroidism predicts outcome in heart failure: insights from the T.O.S.CA. registry
Authors: De Luca Mariarosaria , D’Assante Roberta , Iacoviello Massimo , Triggiani Vincenzo , Rengo Giuseppe , De Giorgi Alfredo , Limongelli Giuseppe , Masarone Daniele , Volterrani Maurizio , Mancini Antonio , Passantino Andrea , Perrone Filardi Pasquale , Sciacqua Angela , Vriz Olga , Castello Roberto , Campo Michela , Lisco Giuseppe , Modesti Pietro Amedeo , Paolillo Stefania , Suzuki Toru , Salzano Andrea , Marra Alberto Maria , Bossone Eduardo , Cittadini Antonio ,   T.O.S.CA. Investigators
Published: June 2024

AbstractSubclinical hypothyroidism (SH), defined as increased serum thyroid-stimulating hormone (TSH) with normal free T4 (fT4) levels, is frequently observed in the general population. Prevalence ranges from 0.6% to 1.8% in the adult population, depending on age, sex, and iodine intake. Several studies reported a worse prognosis in patients with heart failure with reduced ejection fraction (HFrEF) and SH, but they considered heterogeneous populations suffering mainly from severe SH. Aim of this study was to evaluate if SH was independently associated with the occurrence of cardiovascular death considering 30 months of follow-up. 277 HFrEF patients enrolled in the prospective, multicenter, observational T.O.S.CA. (Terapia Ormonale Scompenso CArdiaco) registry, were included in this analysis. Patients were divided into two groups according to the presence of SH (serum TSH levels > 4.5 mIU/L with normal fT4 levels). Data regarding clinical status, echocardiography, and survival were analyzed. Twenty-three patients displayed SH (87% mild vs 13% severe), while 254 were euthyroid. No differences were found in terms of age, sex, HF etiology, and left ventricular ejection fraction. When compared with the euthyroid group, SH patients showed higher TSH levels (7.7 ± 4.1 vs 1.6 ± 0.9, p < 0.001), as expected, with comparable levels of fT4 (1.3 ± 0.3 vs 1.3 ± 0.3, p = NS). When corrected for established predictors of poor outcome in HF, the presence of SH resulted to be an independent predictor of cardiovascular mortality (HR: 2.96; 5–95% CI:1.13–7.74; p = 0.03). Since thyroid tests are widely available and inexpensive, they should be performed in HF patients to detect subclinical disorders, evaluate replacement therapy, and improve prognosis.
The Truncated Moment Problem on Reducible Cubic Curves I: Parabolic and Circular Type Relations
Authors: Yoo Seonguk , Zalar Aljaž 
Published: June 2024

AbstractIn this article we study the bivariate truncated moment problem (TMP) of degree 2k on reducible cubic curves. First we show that every such TMP is equivalent after applying an affine linear transformation to one of 8 canonical forms of the curve. The case of the union of three parallel lines was solved in Zalar (Linear Algebra Appl 649:186–239, 2022. https://doi.org/10.1016/j.laa.2022.05.008), while the degree 6 cases in Yoo (Integral Equ Oper Theory 88:45–63, 2017). Second we characterize in terms of concrete numerical conditions the existence of the solution to the TMP on two of the remaining cases concretely, i.e., a union of a line and a circle $$y(ay+x^2+y^2)=0, a\in {\mathbb {R}}{\setminus } \{0\}$$

y

(
a
y
+

x
2

+

y
2

)

=
0
,
a
∈
R
\

{
0
}

, and a union of a line and a parabola $$y(x-y^2)=0$$

y
(
x
-

y
2

)
=
0

. In both cases we also determine the number of atoms in a minimal representing measure.
Backtracking New Q-Newton’s Method, Newton’s Flow, Voronoi’s Diagram and Stochastic Root Finding
Authors: Fornæss John Erik , Hu Mi , Truong Tuyen Trung , Watanabe Takayuki 
Published: June 2024

AbstractA new variant of Newton’s method - named Backtracking New Q-Newton’s method (BNQN) - which has strong theoretical guarantee, is easy to implement, and has good experimental performance, was recently introduced by the third author. Experiments performed previously showed some remarkable properties of the basins of attractions for finding roots of polynomials and meromorphic functions, with BNQN. In general, they look more smooth than that of Newton’s method. In this paper, we continue to experimentally explore in depth this remarkable phenomenon, and connect BNQN to Newton’s flow and Voronoi’s diagram. This link poses a couple of challenging puzzles to be explained. Experiments also indicate that BNQN is more robust against random perturbations than Newton’s method and Random Relaxed Newton’s method.
The Role of Platelet Rich Plasma in Vertebrogenic and Discogenic Pain: A Systematic Review and Meta-Analysis
Authors: Kataria Saurabh , Wijaya Jeremiah Hilkiah , Patel Utsav , Yabut Kevin , Turjman Tawfiq , Ayub Muhammad Abubakar , Upadhyay Nihar , Makrani Moinulhaq , Turjman Hisham , Mohamed Ahmed Mostafa Abdalla , Kaye Alan D. 
Published: June 2024

Abstract
Purpose of Review
The present investigation evaluates clinical uses and roles of platelet rich plasma in the management of vetrebrogenic and discogenic mediated pain states.

Recent Findings
Back pain is a common and significant condition that affects millions of people around the world. The cause of back pain is often complex and multifactorial, with discogenic and vertebrogenic pain being two subtypes of back pain. Currently, there are numerous methods and modalities in which back pain is managed and treated such as physical therapy, electrical nerve stimulation, pharmacotherapies, and platelet-rich plasma. To conduct this systematic review, the authors used the keywords “platelet-rich plasma”, “vertebrogenic pain”, and “discogenic pain”, on PubMed, EuroPMC, Who ICTRP, and clinicaltrials.gov to better elucidate the role of this treatment method for combating vertebrogenic and discogenic back pain. In recent decades, there has been a rise in popularity of the use of platelet-rich plasma for the treatment of numerous musculoskeletal conditions. Related to high concentration of platelets, growth factors, cytokines, and chemokines, platelet-rich plasma is effective in reducing pain related symptoms and in the treatment of back pain.

Summary
Platelet-rich plasma use has evolved and gained popularity for pain related conditions, including vertebrogenic and discogenic back pain. Additional well-designed studies are warranted in the future to better determine best practice strategies to provide future clinicians with a solid foundation of evidence to make advancements with regenerative medical therapies such as platelet-rich plasma.
Electrophysiological Profile of Different Antiviral Therapies in a Rabbit Whole-Heart Model
Authors: Wolfes Julian , Kirchner Lina , Doldi Florian , Wegner Felix , Rath Benjamin , Eckardt Lars , Ellermann Christian , Frommeyer Gerrit 
Published: June 2024

AbstractAntiviral therapies for treatment of COVID-19 may be associated with significant proarrhythmic potential. In the present study, the potential cardiotoxic side effects of these therapies were evaluated using a Langendorff model of the isolated rabbit heart. 51 hearts of female rabbits were retrogradely perfused, employing a Langendorff-setup. Eight catheters were placed endo- and epicardially to perform an electrophysiology study, thus obtaining cycle length-dependent action potential duration at 90% of repolarization (APD90), QT intervals and dispersion of repolarization. After generating baseline data, the hearts were assigned to four groups: In group 1 (HXC), hearts were treated with 1 µM hydroxychloroquine. Thereafter, 3 µM hydroxychloroquine were infused additionally. Group 2 (HXC + AZI) was perfused with 3 µM hydroxychloroquine followed by 150 µM azithromycin. In group 3 (LOP) the hearts were perfused with 3 µM lopinavir followed by 5 µM and 10 µM lopinavir. Group 4 (REM) was perfused with 1 µM remdesivir followed by 5 µM and 10 µM remdesivir. Hydroxychloroquine- and azithromycin-based therapies have a significant proarrhythmic potential mediated by action potential prolongation and an increase in dispersion. Lopinavir and remdesivir showed overall significantly less pronounced changes in electrophysiology. In accordance with the reported bradycardic events under remdesivir, it significantly reduced the rate of the ventricular escape rhythm.
Linc00239 Facilitates the Progress of Clear Cell Renal Cell Carcinoma via the miR-204-5p/RAB22A Axis
Authors: Cheng Cheng , Lin Shuangquan , Zhu Anyi , Hong Zhengdong , Shi Zimin , Deng Huanhuan , Zhang Gan 
Published: June 2024

AbstractLong intergenic non-coding RNA 239 (Linc00239) acts as an oncogene in colorectal cancer (CRC), esophageal squamous cell carcinoma, and acute myeloid leukemia cells. However, its role and regulatory mechanisms in clear cell renal cell carcinoma (ccRCC) remain unknown. We used StarBase and The Cancer Genome Atlas databases to evaluate Linc00239 expression and its effect on ccRCC. Furthermore, the function of Linc00239 in ccRCC proliferation and metastasis was analyzed using Cell Counting Kit-8 and Transwell assays following Linc00239 knockdown. Subsequently, the Linc00239-miRNA-mRNA regulatory associations were selected based on miRanda, miTarbase, and previous references, and their expression levels and binding relationship were further validated using quantitative real-time polymerase chain reaction, western blotting and dual-luciferase reporter gene assay. Additionally, we transfected a miRNA inhibitor to evaluate whether the miR-204-5p/RAB22A (Ras-related proteins in brain 22a) axis was involved in Linc00239 function. Linc00239 was elevated in ccRCC and correlated with poor prognosis. Linc00239 knockdown inhibited ccRCC progression. Additionally, Linc00239 inhibition elevated miR-204-5p expression and repressed RAB22A levels. Moreover, miR-204-5p inhibitors attenuated this inhibitory effect on proliferation, migration, invasion, and RAB22A level when Linc00239 was knocked down. Linc00239 promotes ccRCC proliferation and metastasis by elevating RAB22A expression through the adsorption of miR-204-5p, which provides a clue for the diagnosis and treatment of ccRCC.
Management Practices, Pay, and Pay Inequality
Authors: Monteiro Natália P. , Straume Odd Rune 
Published: June 2024

AbstractWe use rich Portuguese data to analyse the relationship between the use of different management practices and worker pay in a large representative sample of firms. We find that the overall score on the use of management practices is significantly associated with both higher average wages and higher within-firm wage dispersion. The positive relationship between management practices and average pay is present throughout the wage distribution and for all occupational skill groups, but is stronger for workers higher up in the wage distribution and in higher-skilled occupations. These results are driven by incentives-based management practices, in particular practices related to reward and promotion of high performers in the firm. We also identify a potential moderating role of works councils. Our results suggests that, in firms with works councils, a larger share of the gains from productivity-enhancing management practices is shared with workers, and these gains are more evenly distributed across the workforce.
The Poor Integration Results of the Common European Asylum System Compared to the Temporary Protection Directive: The Case of the Netherlands
Authors: Doomernik Jeroen , van Heelsum Anja 
Published: June 2024

AbstractTaking the case of the Netherlands, we compare integration outcomes of the traditional asylum reception system (implementing the Refugee Convention), applied to, for example, Syrians and Afghans, and the EU’s Temporary Protection Directive (TPD) which is applied to Ukrainians. We show that the TPD is not just less costly for receiving countries but also results in much faster labor market integration. While rapid integration is an important policy goal, the traditional asylum system is not effective, and talents are underutilized. We show how spatial and temporal aspects of the asylum procedures for Common European Asylum System (CEAS) refugees lead to slow integration, while Ukrainians under TPD work immediately and can build connections in Dutch society.
“A good night’s sleep!” How do remote workers juggle work and family during lockdown? Some answers from a French mixed-methods study
Authors: Dolce Valentina , Ghislieri Chiara , Molino Monica , Vayre Émilie 
Published: June 2024

AbstractThis study, based primarily on job demands–resources model in the context of recovery, uses a mixed methods approach to examine the role that some work and family demands and boundary management tactics play in explaining work-nonwork balance and some related constructs, while also accounting for gender inequalities. The research involved 553 remote workers during the first lockdown in France caused by the COVID-19 pandemic. The results confirmed that a high number of work-related emails or phone calls outside of working hours and the constant presence of children at home were risk factors; conversely, good supervisor support was positively related to recovery experiences and negatively related to work-family conflict and insomnia. Women reported higher levels of insomnia symptoms and had more difficulty disengaging from work and restoring their energy than men. The use of effective tactics– planning, having your own space to work, coordinating with your partner - was made more difficult by workload, use of technology, demands at home, the size of the home and, for women, likely gender inequalities.