bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety, Efficacy, and Performance of Implanted Recycled Cardiac Rhythm Management (CRM) Devices in Underprivileged Patients
Authors: HASAN REEMA , GHANBARI HAMID , FELDMAN DUSTIN , MENESSES DANIEL , RIVAS DANIEL , ZAKHEM NICOLE C. , DUARTE CARLOS , MACHADO CHRISTIAN 
Published: March 2011

Introduction: Patients in underdeveloped nations have limited access to life‐saving medical technology including cardiac rhythm management (CRM) devices. We evaluated alternative means to provide such technology to this patient population while assessing the safety and efficacy of such a practice.
Methods: Patients in the United States with clinical indications for extraction of CRM devices were consented. Antemortem CRM devices were cleaned and sterilized following a protocol established at our institution. Surveillance in vitro cultures were performed for quality assurance. The functional status of pulse generators was tested with a pacing system analyzer to confirm at least 70% battery life. Most generators were transported, in person, to an implanting institution in Nicaragua. Recipients with a Class I indication for CRM implantation, and meeting economical criteria set forth, were consented for implantation of a recycled device.
Results: Between 2003 and 2009, implantation was performed in 17 patients with an average age of 42.1 ± 20.3 years. Of the 17 patients, nine were male and eight were female. Mean follow‐up was 68 ± 38 months. Device evaluation occurred prior to discharge, 4 weeks post implantation, and every 6 months thereafter. There were three deaths during the follow‐up period secondary to myocardial infarction, stroke, and heart failure. Hematoma formation occurred in one patient. No infections, early battery depletion, or device malfunction were identified during follow‐up.
Conclusions: Our case series is the longest follow‐up of recipients of recycled antemortem CRM devices. Our findings support the feasibility and safety of this alternative acquisition of life‐saving technology. (PACE 2011; 653–658)
Case Fatality in Children with Supraventricular Tachycardia in the United States
Authors: SALERNO JACK C. , GARRISON MICHELLE M. , LARISON CINDY , SESLAR STEPHEN P. 
Published: March 2011

Background: The prognosis for most patients with supraventricular tachycardia (SVT) is thought to be excellent. However, the fatality rate in children with SVT is poorly defined and there are no large‐scale, multicenter studies to support this commonly held belief.
Methods: We reviewed an administrative database containing inpatient records from 41 stand‐alone children's hospitals and identified all hospitalized patients younger than 25 years with a discharge diagnosis of SVT between January 2003 and September 2008.
Results: We analyzed the index hospitalization of 1,755 patients with the discharge diagnosis of SVT, of whom 58% were male and 52% had comorbid structural heart disease (SHD). There were a total of 68 patient deaths (4%) with 56 of 68 (82%) of the deaths occurring in patients with SHD. In total, 6% of the patients with SHD died, whereas only 1% of the patients without SHD died. Regression analysis revealed that case fatality is increased in patients less than 1 month of age (OR 2.41, 95% CI 1.35 to 4.32), in patients with SHD (OR 2.67, 95% CI 1.22 to 5.80), and in those having cardiomyopathy with (OR 6.72, 95% CI 1.79 to 25.28) and without SHD (OR 6.74, 95% CI 1.67 to 27.26).
Conclusions: The case fatality in patients who have SVT without SHD is low. It is increased in the very young and in those with comorbid cardiovascular disease. Case fatality is highest in patients with a cardiomyopathy regardless of SHD. (PACE 2011; 34:832–836)
The role of CXCR7 on the adhesion, proliferation and angiogenesis of endothelial progenitor cells
Authors: Dai Xiaozhen , Tan Yi , Cai Shaoxi , Xiong Xin , Wang Lingqiao , Ye Qunfang , Yan Xiaoqing , Ma Kaiwang , Cai Lu 
Published: March 2011

AbstractPrevious studies confirmed that stromal cell‐derived factor 1 (SDF‐1) was a principal regulator of retention, migration and mobilization of haematopoietic stem cells and endothelial progenitor cells (EPCs) during steady‐state homeostasis and injury. CXC chemokine receptor 4 (CXCR4) has been considered as the unique receptor of SDF‐1 and as the only mediator of SDF‐1‐induced biological effects for many years. However, recent studies found that SDF‐1 could bind to not only CXCR4 but also CXC chemokine receptor 7 (CXCR7). The evidence that SDF‐1 binds to the CXCR7 raises a concern how to distinguish the potential contribution of the SDF‐1/CXCR7 pathway from SDF‐1/CXCR4 pathway in all the processes that were previously attributed to SDF‐1/CXCR4. In this study, the role of CXCR7 in EPCs was investigated in vitro. RT‐PCR, Western blot and flow cytometry assay demonstrate that both CXCR4 and CXCR7 were expressed highly in EPCs. The adhesion of EPCs induced by SDF‐1 was inhibited by blocking either CXCR4 or CXCR7 with their antibodies or antagonists. SDF‐1 regulated the migration of EPCs via CXCR4 but not CXCR7. However, the transendothelial migration of EPCs was inhibited by either blocking of CXCR4 or CXCR7. Both CXCR7 and CXCR4 are essential for the tube formation of EPCs induced by SDF‐1. These results suggested that both CXCR7 and CXCR4 are important for EPCs in response to SDF‐1, indicating that CXCR7 may be another potential target molecule for angiogenesis‐dependent diseases.
Matrix metalloproteinases: protective roles in cancer
Authors: Decock Julie , Thirkettle Sally , Wagstaff Laura , Edwards Dylan R. 
Published: March 2011

Abstract

Introduction
MMP‐3
MMP‐8
MMP‐9
MMP‐12
MMP‐19
MMP‐26
Conclusions

The original notion that matrix metalloproteinases (MMPs) act as tumour and metastasis‐promoting enzymes by clearing a path for tumour cells to invade and metastasize has been challenged in the last decade. It has become clear that MMPs are involved in numerous steps of tumour progression and metastasis, and hence are now considered to be multifaceted proteases. Moreover, more recent experimental evidence indicates that some members of the MMP family behave as tumour‐suppressor enzymes and should therefore be regarded as anti‐targets in cancer therapy. The complexity of the pro‐ and anti‐tumorigenic and ‐metastatic functions might partly explain why broad‐spectrum MMP inhibitors failed in phase III clinical trials. This review will provide a focussed overview of the published data on the tumour‐suppressive behaviour of MMPs.
FACS‐purified myoblasts producing controlled VEGF levels induce safe and stable angiogenesis in chronic hind limb ischemia
Authors: Wolff Thomas , Mujagic Edin , Gianni‐Barrera Roberto , Fueglistaler Philipp , Helmrich Uta , Misteli Heidi , Gurke Lorenz , Heberer Michael , Banfi Andrea 
Published: March 2011

AbstractWe recently developed a method to control the in vivo distribution of vascular endothelial growth factor (VEGF) by high throughput Fluorescence‐Activated Cell Sorting (FACS) purification of transduced progenitors such that they homogeneously express specific VEGF levels. Here we investigated the long‐term safety of this method in chronic hind limb ischemia in nude rats. Primary myoblasts were transduced to co‐express rat VEGF‐A164 (rVEGF) and truncated ratCD8a, the latter serving as a FACS‐quantifiable surface marker. Based on the CD8 fluorescence of a reference clonal population, which expressed the desired VEGF level, cells producing similar VEGF levels were sorted from the primary population, which contained cells with very heterogeneous VEGF levels. One week after ischemia induction, 12 × 106 cells were implanted in the thigh muscles. Unsorted myoblasts caused angioma‐like structures, whereas purified cells only induced normal capillaries that were stable after 3 months. Vessel density was doubled in engrafted areas, but only approximately 0.1% of muscle volume showed cell engraftment, explaining why no increase in total blood flow was observed. In conclusion, the use of FACS‐purified myoblasts granted the cell‐by‐cell control of VEGF expression levels, which ensured long‐term safety in a model of chronic ischemia. Based on these results, the total number of implanted cells required to achieve efficacy will need to be determined before a clinical application.
Cortical network from human embryonic stem cells
Authors: Nat Roxana 
Published: March 2011

AbstractThe connection of embryonic stem cell technology and developmental biology provides valuable tools to decipher the mechanisms underlying human brain development and diseases, especially among neuronal populations, that are not readily available in primary cultures. It is obviously the case of neurons forming the human cerebral cortex. In the images that are presented, the neurons were generated in vitro from human embryonic stem cells via forebrain‐like progenitors. Maintained in culture for prolonged time, they acquired a mainly glutamatergic phenotype and morphological characteristics of cortical pyramidal neurons, including dendritic spines, and formed spectacular networks.
Quality assessment of randomised controlled trials of dental implant surgery and prosthodontics published from 2004 to 2008: a systematic review
Authors: Vere Joe , Joshi Rajendra 
Published: March 2011

AbstractAim: The aim of this systematic review was to assess the methodological and statistical quality of randomised controlled trials of treatment interventions of dental implant surgery and prosthodontics published between 2004 and 2008.Method: Randomised controlled trials were identified following detailed searches of Medline, EMBASE, CINHAL and the Cochrane Central Register of Controlled Trials. Identified studies were independently assessed by two non‐blinded reviewers for 14 key methodological and statistical domains. Information was collected using a customised data collection sheet.Results: The initial Medline search yielded 1484 studies. Following application of inclusion criteria 38 randomised controlled trials, not presenting the same patient material, were identified for this review. Inter‐examiner agreement was assessed for all domains (median κ score 0.7). All disagreements were resolved by discussion. Randomisation was adequate in 16 trials (42%), allocation concealment was adequate in seven trials (18%) and outcome assessment was blind in 12 trials (31%). Seven trials (18%) tested the intra/inter‐examiner reliability of at least one outcome of interest. Confidence intervals were reported in two trials (5%). Seventeen different statistical tests were used. However, inferential statistical analysis was considered appropriate in only 22 trials (57%).Conclusions: Randomised controlled trials of treatment interventions of dental implant surgery and prosthodontics published between 2004 and 2008 are poorly reported and, by themselves, provide little unbiased evidence to support the clinical decisions that we make.To cite this article:
Vere J, Joshi R. Quality assessment of randomised controlled trials of dental implant surgery and prosthodontics published from 2004 to 2008: a systematic review. Clin. Oral Impl. Res. xx, 2011; 000–000. doi: 10.1111/j.1600‐0501.2010.02124.x
Heat production during different ultrasonic and conventional osteotomy preparations for dental implants
Authors: Rashad Ashkan , Kaiser Anja , Prochnow Nora , Schmitz Inge , Hoffmann Eike , Maurer Peter 
Published: March 2011

AbstractObjectives: The purpose of this study was to evaluate the intraosseous temperature changes during ultrasonic and conventional implant site preparation in vitro with respect to the effect of load and irrigation volume.Material and methods: Implant sites were prepared using two different ultrasonic devices (Piezosurgery, Mectron Medical Technology and VarioSurg, NSK) and one conventional device (Straumann) at loads of 5, 8, 15 and 20 N and with irrigation volumes of 20, 50 and 80 ml/min. During implant site preparation, temperatures were measured in fresh, equally tempered bovine ribs using two thermocouples placed at a distance of 1.5 mm around the drilling site in cortical and cancellous bone. The preparation time was recorded.Results: The heat production and time required for implant site preparation using both ultrasonic devices were significantly higher than those for conventional drilling (P<0.01). Increased loading had no effect on heat production. A higher irrigation volume was associated with a diminished temperature increase in the cortical bone for ultrasonic but not for conventional drilling, which resulted in significantly lower temperatures in cortical as compared with cancellous bone during ultrasonic implant site preparation.Conclusions: Ultrasonic implant site preparation is more time consuming and generates higher bone temperatures than conventional drilling. However, with the levels of irrigation, ultrasonic implant site preparation can be an equally safe method.To cite this article:
Rashad A, Kaiser A, Prochnow N, Schmitz I, Hoffmann E, Maurer P. Heat production during different ultrasonic and conventional osteotomy preparations for dental implants. Clin. Oral Impl. Res. xx, 2011; 000–000. doi: 10.1111/j.1600‐0501.2010.02126.x
The effects of bone grafting material and a collagen membrane in the ridge splitting technique: an experimental study in dogs
Authors: Han Ji‐Young , Shin Seung‐Il , Herr Yeek , Kwon Young‐Hyuk , Chung Jong‐Hyuk 
Published: March 2011

AbstractObjectives: This study was designed to evaluate the effect of bone graft materials and collagen membranes in ridge splitting procedures with immediate implant placement using a dog model.Materials and methods: Mandibular premolars were extracted in five beagle dogs. After 3 months, ridge splitting and placement of three OsseoSpeed™ implants were performed bilaterally. The gaps between the implants were allocated according to the following eight treatment modalities; Group 1(no graft), Group 2 (autogenous bone), Group 3 (Bio‐Oss® Collagen), Group 4 (Bio‐Oss®), Group 5 (no graft+BioGide®), Group 6 (autogenous bone+BioGide®), Group 7 (Bio‐Oss® Collagen+BioGide®), and Group 8 (Bio‐Oss®+BioGide®). The dogs were sacrificed after 8 or 12 weeks and the specimens were analyzed histologically and histometrically.Results: The gaps between the implants were filled with the newly formed bone, irrespective of which of the eight grafting techniques was used. Group 1 revealed a significantly lower percentage of bone‐to‐implant contact (BIC) than Group 5 at 8 and 12 weeks (P<0.05). Group 1 showed the most prominent marginal bone loss (MBL) at 12 weeks (P<0.05). Regarding the use of membranes, Groups 1 and 2 showed significantly more MBL than Groups 5 and 6 at 12 weeks (P<0.05).Conclusions: After ridge splitting, if the gaps between implants were grafted or covered with collagen membranes, a higher percentage of BIC was obtained. Based on our results, we suggest that the use of bone graft materials and/or collagen membranes is better for the prevention of MBL after ridge splitting procedures.To cite this article:
Han J‐Y, Shin S‐I, Herr Y, Kwon Y‐H, Chung J‐H. The effects of bone grafting material and a collagen membrane in the ridge splitting technique: an experimental study in dogs. Clin. Oral Impl. Res. xx, 2011; 000–000 doi: 10.1111/j.1600‐0501.2010.02127.x
Intramembraneous bone tissue responses to calcium sulfate: an experimental study in the rabbit maxilla
Authors: Dasmah A. , Sennerby L. , Rasmusson L. , Hallman M. 
Published: March 2011

AbstractObjectives: The purpose of this study was to histologically examine the responses of intramembraneous bone to calcium sulfate (CaS) and evaluate the resorption and replacement process.Material and methods: Fourteen rabbits were used in this study. Defect healing without any filling material was compared with CaS. Five millimetres wide and 4 mm deep defects were drilled with a trephine bur on both sides of the edentulous space between the incisors and the molars. Test vs. control sites were randomly selected and thereby compared in each animal. The animals were killed after 2, 4 and 8 weeks for histological examination.Results: After 2 weeks, the specimens showed a great extent of degradation of CaS. No signs of the material could be seen after 4 and 8 weeks. There were no statistically significant differences in bone regeneration between the test and control sites within the 8 weeks group in this study. However, there was tendency of more blood vessels in the test sites after 4 weeks of healing.Conclusion: The present study showed that CaS does not interfere with intramembraneous bone healing. In this animal model, the CaS exhibited resorption/degradation early in the healing process while seemingly stimulating angiogenesis. However, there was no significant increase in bone regeneration in the sites treated with CaS during an 8 week period of healing and observation time, as compared with a control defect.To cite this article:
Dasmah A, Sennerby L, Rasmusson L, Hallman M. Intramembraneous bone tissue responses to calcium sulfate: an experimental study in the rabbit maxilla. Clin. Oral Impl. Res. xx, 2011; 000–000. doi: 10.1111/j.1600‐0501.2010.02129.x
Long‐term respiratory symptoms following oesophageal atresia
Authors: Gatzinsky Vladimir , Jönsson Linus , Ekerljung Linda , Friberg Lars‐Göran , Wennergren Göran 
Published: March 2011

AbstractBackground:  Oesophageal atresia (OA) is a congenital malformation that can lead to persistent respiratory symptoms in adulthood.Aim:  To describe the prevalence of respiratory symptoms in adulthood in a population‐based study of patients with repaired OA and to compare this with the prevalence in the general population.Methods:  Of 80 patients operated for OA in Gothenburg in 1968–1983, 79 were located. The patients received a questionnaire on respiratory symptoms. Controls were 4979 gender‐ and age‐matched subjects who answered the same questions.Results:  The questionnaire was answered by 73 of 79 (92%) patients. Physician‐diagnosed asthma was reported by 30% in the OA group vs 10% in the control group (OR 4.1; 95% CI 2.4–6.8), and recurrent wheeze in 29% vs 5.5% (OR 6.9; 4.1–11.6). Also wheeze during the last year, asthma medication, a long‐standing cough, cough with sputum production and chronic bronchitis were significantly more common among the patients with OA. In contrast, there was no significant difference regarding risk factors for asthma. The prevalence of respiratory symptoms did not appear to decrease with age.Conclusion:  A high prevalence of respiratory symptoms remains among adult patients with repaired OA. Many of the patients had an asthma diagnosis. However, asthma heredity or allergic rhinitis was not overrepresented.
Data monitoring committees, interim analysis and early termination in paediatric trials
Authors: Fernandes Ricardo M , van der Lee Johanna H , Offringa Martin 
Published: March 2011

AbstractAim:  To evaluate whether paediatric randomized clinical trials (RCTs) adopt recent guidance on Data Monitoring Committees (DMCs), interim analysis and early termination.Methods:  We reviewed paediatric RCTs that reported on DMCs, interim analysis or early termination, published in eight general medical and paediatric journals (2005–2007). We searched full‐text databases for eligible trials and recorded predefined parameters on each item. Reported activities were compared with current scientific guidance.Results:  A total of 110 of 648 paediatric trials (17%) reported on DMC, interim analysis or early stopping. Various approaches for convening a DMC were identified; information on DMC composition and independence was limited. Strict predefined statistical stopping ‘rules’ were reported in 10 of 23 trials, and interim analyses were more frequently performed on efficacy than on safety outcomes (39/45 vs 27/45). No adjustment for repeated testing was reported in 11 of 33 trials reporting monitoring methods and in 7 of 17 early terminated trials. Validity of results from early stopped trials was threatened by small sample sizes. Incomplete reporting hampered a full analysis.Conclusion:  Few paediatric trials report on DMCs’ roles, interim analysis or early stopping. Heterogeneous practices and apparent shortcomings jeopardize the validity of trial results. Easily accessible guidelines for the design, conduct and reporting of paediatric DMCs are needed.
TRIBOLOGICAL STUDY OF SUSPENSIONS OF CYSTEINE‐RICH PROTEIN STABILIZED MICROBUBBLES AND SUBSEQUENT TRIPHASIC A/O/W EMULSIONS
Authors: TCHUENBOU‐MAGAIA FIDELINE L. , COX PHILIP W. 
Published: March 2011

ABSTRACTWhen developing low‐fat foods, one of the main concerns is the sensory performance which is generally inferior to that of the full‐fat version. Micron‐sized air cells coated and stabilised by proteins (0.5–10 µm) have been produced sonochemically using different cysteine‐rich proteins (hydrophobin, bovine serum albumin [BSA] and egg white proteins [EWPs]). These suspensions of air cells have been termed “air filled emulsions” (AFEs) and suggested for the production of low‐fat emulsion‐based products. This study explores the oral (tribological) behavior of AFEs as ingredients and within a triphasic A/O/W emulsion‐based prototype salad dressing. Tribological measurement of AFEs yielded different results for BSA‐AFE and EWP‐AFE, indicating that the very nature of the protein may play a crucial role. However, the triphasic A/O/W emulsion showed similar, if not better, lubrication properties than the standard O/W version, indicating that AFEs may contribute to the perceived fat‐related attributes.PRACTICAL APPLICATIONSThe tribological behavior of a material has been postulated as relevant for its in‐mouth perception, especially when considering fat‐related attributes. The present study deals with tribological study of novel air‐based ingredients. Knowing the tribological/lubrication behavior of these ingredients and their subsequent products could be useful for better understanding of their possible behavior in the mouth. Also, this could assist in redesigning ingredients and formulations with better sensory performance.
MECHANICAL AND ACOUSTIC PROPERTIES OF SPRING WHEAT VERSUS ITS TECHNOLOGICAL QUALITY FACTORS
Authors: MARZEC AGATA , CACAK‐PIETRZAK GRAŻYNA , GONDEK EWA 
Published: March 2011

ABSTRACTThe objective of this study was the mechanical test and acoustic emission method as tools for the determination of a parameter to be applied for wheat grain differentiation, as well as to determine correlations between mechanical and acoustic parameters and technological factors of grain quality. The force of compression (from among analyzed mechanical traits of grain), and the number of acoustic events and acoustic energy (from among acoustic descriptors) were found to well differentiate the analyzed varieties of wheat. Owing to significant correlations noted between hardness and the number of acoustic events as well as protein content and partition power spectrum slope, these descriptors may be found useful in the evaluation of the technological quality of wheat grain. The analysis of correlations between mechanical and acoustic parameters versus technological factors of grain quality demonstrated that the acoustic method might be successfully applied in the technological evaluation of grain.PRACTICAL APPLICATIONSProducers of cereal preserves set precise requirements regarding quality of wheat grain. The fulfillment of these requirements is essential in order to obtain cereal products of good and consumer‐approved quality and also to ensure correctness of the manufacturing process. Most of the standard determinations are quite labor intensive, and inconvenient during the routine examinations which should be conducted during purchase of grain; hence there is the need to find new, quick and simple examination methods useful for the quality assessment of wheat grain, both at the moment of purchase and during the manufacturing process. Such methods include mechanical methods and recently introduced acoustic methods.