bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shifting of food sources affect abundance of yeast like symbionts in Lasioderma serricorne (F.)
Authors: Clinton Paul X. , Srinivasan Thanga Suja , Peñalver Cruz Ainara , Premachandran Krishnamanikumar 
Published: June 2024

AbstractHost diet is one of the key factors that shapes insect associated microbial communities, and the impact of dietary shift on abundance of microbial communities and insect fitness is poorly understood. Cigarette beetle (Lasioderma serricorne (F.)) are in close association with yeast symbionts for nutritional and defence benefits. The present study highlights that dietary source determines the yeast abundance in cigarette beetle and any change in diet induces a shift in yeast abundance. A general trendline of increase in yeast abundance during larval and pupal stage followed by a drop in adult stages of cigarette beetle was observed among all diet sources. The yeast abundance varied among diet sources and was significantly higher on natal (wheat) and reverted colonies compared to other exposed dietary sources. Yeast abundance in reverted colonies of soybean and bengal gram increased to the levels of those that were originally feeding on wheat suggesting a similar microbial structure among those diet sources. The correlation between yeast abundance and beetle biomass among diet guilds suggest a predictable relationship between yeast symbionts and diet source. The investigation can provide further insights on yeast symbiont abundance and food source specificity in cigarette beetle biology and management.
The association between proton‐pump inhibitor use and recurrence of hepatocellular carcinoma after hepatectomy
Authors: Ho Chun‐Ting , Fu Chia‐Chu , Tan Elise Chia‐Hui , Kao Wei‐Yu , Lee Pei‐Chang , Huang Yi‐Hsiang , Huo Teh‐Ia , Hou Ming‐Chih , Wu Jaw‐Ching , Su Chien‐Wei 
Published: June 2024

AbstractBackground and AimThe association between long‐term proton‐pump inhibitors (PPIs) use and malignancies had long been discussed, but it still lacks consensus. Our study investigated the association between PPI use and hepatocellular carcinoma (HCC) recurrence following curative surgery.MethodsWe retrospectively enrolled 6037 patients with HCC who underwent hepatectomy. Patients were divided into four groups according to their PPI usage. (non‐users: < 28 cumulative defined daily dose [cDDD]; short‐term users: 28–89 cDDD; mid‐term users: 90–179 cDDD, and long‐term users: ≥ 180 cDDD, respectively). Recurrence‐free survival (RFS) and overall survival (OS) were analyzed using Kaplan–Meier method and Cox proportional hazard models.ResultsAmong the 6037 HCC patients, 2043 (33.84%) were PPI users. PPI users demonstrated better median RFS (3.10 years, interquartile range [IQR] 1.49–5.01) compared with non‐users (2.73 years, IQR 1.20–4.74; with an adjusted hazard ratio [aHR] of 0.57, 95% confidence interval [CI] 0.44–0.74, P < 0.001). When considering the cumulative dosage of PPI, only long‐term PPI users had significant lower risk of HCC recurrence than non‐PPI group (adj‐HR: 0.50; 95% CI: 0.35–0.70; P < 0.001). Moreover, the impact of long‐term PPIs use on improving RFS was significant in most of the subgroup analysis, except in patients with advanced tumor stages, with non‐cirrhosis, or with a history of chronic kidney disease. However, there were no significant differences in median OS between PPI users and non‐users (4.23 years, IQR 2.73–5.86 vs 4.04 years, IQR 2.51–5.82, P = 0.369).ConclusionLong‐term PPI use (≥ 180 cDDD) may be associated with a better RFS in HCC patients after hepatectomy.
Fruit and vegetable consumption among children in Saudi Arabia: Predictors and associations with dietary intake
Authors: Mumena Walaa Abdullah , Kutbi Hebah Alawi 
Published: June 2024

AbstractBackgroundData exploring factors related to the consumption of fruits and vegetables (F&V) among children in Saudi Arabia are lacking. The present study aimed to evaluate F&V consumption among Saudi children. Predictors of F&V intake and associations with dietary intake were also explored.MethodsCross‐sectional data of 424 Saudi children (6–12 years) were collected from their mothers using an online survey. Phone interviews were conducted with mothers and children to provide data on dietary intake of children.ResultsMost children included in the study (92.2%, n = 391) consumed less than five servings of F&V per day. Region of residency (B = −0.14, SE = 0.06, 95% confidence interval [CI] = −0.25 to −0.02, p = 0.019), paternal education level (B = 0.52, SE = 0.14, 95% CI = 0.24–0.79, p < 0.001) and family monthly income (B = 0.15, SE = 0.07, 95% CI = 0.01–0.29, p = 0.034) predicted the intake of F&V. Food neophobia and food pickiness also predicted the intake of F&V (B = −0.16, SE = 0.06, 95% CI = −0.27 to −0.05, p = 0.005 and B = −0.24, SE = 0.06, 95% CI = −0.36 to −0.12, p < 0.001, respectively). Children's intake of F&V positively predicted the intake of fibre, potassium, phosphorus, magnesium, iodine and vitamin C.ConclusionsLimited intake of F&V was observed among Saudi children. F&V consumption was found to be associated with a number of sociodemographic factors, including region of residency, paternal education level and family income, as well as children's food neophobia and pickiness. Children's intake of F&V predicted higher intake of fibre, potassium, phosphorus, magnesium, iodine and vitamin C, suggesting that F&V consumption may contribute to improved intake of key nutrients in children.
A Pilot Evaluation of the Respect You Curriculum
Authors: Bennett Carly J. , Glassman Tavis J. , Saltzman Barbara , Dake Joseph A. , Kruse‐Diehr Aaron 
Published: June 2024

ABSTRACTBACKGROUNDThe objective of this study is to evaluate the Respect YOU program's impact on students' eating expectancies, body image satisfaction levels, self‐efficacy, and knowledge. A total of 444 (intervention cohort n = 348, control cohort n = 96) underclassmen enrolled in health or physical education courses from 7 high schools in the Midwest participated in the study.METHODSA repeated measure research design was utilized to assess students' eating expectancies, body image satisfaction levels, self‐efficacy, and knowledge. More specifically, paired t‐tests were conducted to compare outcome measurements to evaluate the efficacy of the intervention.RESULTSAmong the students who received the intervention (n = 348), there was a statistically significant change in scores for eating expectancies (Z = −14.403, p < .001), body image satisfaction levels (Z = −14.114, p < .001), social media self‐efficacy (Z = 14.868, p < .001), and knowledge scales (Z = −16.100, p < .001) at post‐intervention and compared to the control group.CONCLUSIONSResults indicate that the Respect YOU program was effective in improving body image scores, eating expectancies, self‐esteem, and knowledge‐related outcomes among students post‐intervention. These results can be used to further develop educational programming to address body image concerns and disordered eating among adolescents.
A guide to understanding big data for the nurse scientist: A discursive paper
Authors: Duah Henry Ofori , Boch Samantha , Arter Sara , Nidey Nichole , Lambert Joshua 
Published: June 2024

AbstractBig data refers to extremely large data generated at high volume, velocity, variety, and veracity. The nurse scientist is uniquely positioned to leverage big data to suggest novel hypotheses on patient care and the healthcare system. The purpose of this paper is to provide an introductory guide to understanding the use and capability of big data for nurse scientists. Herein, we discuss the practical, ethical, social, and educational implications of using big data in nursing research. Some practical challenges with the use of big data include data accessibility, data quality, missing data, variable data standards, fragmentation of health data, and software considerations. Opposing ethical positions arise with the use of big data, and arguments for and against the use of big data are underpinned by concerns about confidentiality, anonymity, and autonomy. The use of big data has health equity dimensions and addressing equity in data is an ethical imperative. There is a need to incorporate competencies needed to leverage big data for nursing research into advanced nursing educational curricula. Nursing science has a great opportunity to evolve and embrace the potential of big data. Nurse scientists should not be spectators but collaborators and drivers of policy change to better leverage and harness the potential of big data.
Relationships Between Running Biomechanics and Femoral Articular Cartilage Thickness and Composition in Anterior Cruciate Ligament Reconstruction Patients
Authors: Lee Hyunwook , Clinger Dallin , Oh Minsub , Han Seunguk , Allen Steven P. , Page Garritt L. , Bruening Dustin A. , Hyldahl Robert D. , Hopkins J. Ty , Seeley Matthew K. 
Published: June 2024

ABSTRACTBackgroundAlthough individuals with anterior cruciate ligament reconstruction (ACLR) are at high risk for posttraumatic osteoarthritis, mechanisms underlying the relationship between running and knee cartilage health remain unclear.ObjectiveWe aimed to investigate how 30 min of running influences femoral cartilage thickness and composition and their relationships with running biomechanics in patients with ACLR and controls.MethodsTwenty patients with ACLR (time post‐ACLR: 14.6 ± 6.1 months) and 20 matched controls participated in the study. A running session required both groups to run for 30 min at a self‐selected speed. Before and after running, we measured femoral cartilage thickness via ultrasound imaging. A MRI session consisted of T2 mapping.ResultsThe ACLR group showed longer T2 relaxation times in the medial femoral condyle at resting compared with the control group (central: 51.2 ± 16.6 vs. 34.9 ± 13.2 ms, p = 0.006; posterior: 50.2 ± 10.1 vs. 39.8 ± 7.4 ms, p = 0.006). Following the run, the ACLR group showed greater deformation in the medial femoral cartilage than the control group (0.03 ± 0.01 vs. 0.01 ± 0.01 cm, p = 0.001). Additionally, the ACLR group showed significant negative correlations between resting T2 relaxation time in the medial femoral condyle and vertical impulse (standardized regression coefficients = −0.99 and p = 0.004) during running.ConclusionsOur findings suggest that those who are between 6 and 24 months post‐ACLR have degraded cartilage composition and their cartilage deforms more due to running vGRF.
Distribution of Inflammatory Infiltrate in Feline Mammary Lesions: Relationship With Clinicopathological Features
Authors: Rodrigues‐Jesus Joana , Canadas‐Sousa Ana , Oliveira Pedro , Figueira Ana Catarina , Marrinhas Carla , Petrucci Gonçalo N. , Gregório Hugo , Tinoco Flora , Goulart Andrea , Felga Helena , Vilhena Hugo , Dias‐Pereira Patrícia 
Published: June 2024

ABSTRACTInflammation is a frequent finding in feline mammary neoplasms. Recent research suggests that the presence and location of tumour‐associated immune cells might play a significant role in the clinical outcome of feline mammary carcinomas. The present study aimed to characterise the overall inflammatory infiltrates in healthy, hyperplastic/dysplastic, benign and malignant lesions of the feline mammary gland, and to evaluate its association with clinicopathological features. Perilesional and intralesional inflammatory foci were evaluated in 307 lesions from 185 queens, and categorised according to its distribution and intensity. The presence, location and density of tertiary lymphoid structures were also assessed. A control group included 24 queens without mammary changes. The presence of intralesional and perilesional inflammatory infiltrate was observed in a majority of the lesions (80.8% and 90.2%, respectively), but differed according to the type of mammary lesion, being more remarkable in malignant neoplasms. Only scarce individual cells were observed in 28.1% of the normal mammary glands. Data analysis revealed statistically significant associations (p < 0.05) between the presence of a more prominent intralesional and perilesional inflammatory reaction and several clinicopathological features associated with worse prognosis, including clinical stage, tumour size, mitotic count, lymphovascular invasion and lymph node metastasis. Furthermore, tertiary lymphoid structures were significantly more frequent in tumours with an infiltrative growth and lymph node metastasis. According to our results, the inflammatory reaction present in different types of feline mammary lesions is associated with the development of more aggressive tumours.
Multicenter study investigating long‐term survival after synovial lavage of contaminated and septic synovial structures in horses presented to 10 UK referral hospitals
Authors: de Souza Therese C. , Burford John , Busschers Evita , Freeman Sarah , Suthers Joanna M. 
Published: June 2024

AbstractObjectiveTo report the long‐term survival of adult horses that were subjected to synovial lavage for treatment of contaminated and septic synovial structures.Study designMulticenter, prospective observational trial.AnimalsHorses (n = 240) presented for synovial sepsis at 10 UK referral centers.MethodsData for horses presented for treatment of synovial sepsis were collected over a 15 month recruitment period. Owners were contacted a minimum of 365 days after surgery using a structured client interview to assess long term survival. Descriptive statistics, and univariable and Cox proportional hazards models for postoperative survival time were developed.ResultsSurvival to discharge was 228/240 (95%) and overall long‐term survival was 89.4% (185/207). Unknown cause of injury (p = .017), increasing duration of surgery (p = .003), increasing weight (p = .008), forelimb injuries (p = .027), and type of synovial structure (p = .008) were found to be associated with death using Cox proportional hazards models.ConclusionThis study provides information on risk factors associated with survival and death after treatment for synovial sepsis at referral hospitals in the UK. Survival to discharge and long‐term survival was excellent. Heavier horses, injuries affecting the forelimbs, tendon sheaths and bursae were associated with poorer long term outcomes. Longer duration of surgery was also found to be associated with a worse prognosis.Clinical significanceThese findings help to provide prognostic information for owners and veterinarians treating horses with synovial sepsis.
Modeling and Experimental Data Analysis of Oscillating Heat Pipes: A Review
Authors: Mohammadian Shahabeddin K. , H. Mohammed Ramy , Nunez Roberto , Rupam Tahmid , Spitzenberger Jeremy , Hoelle James , Ibrahim Omar T. , Feng Frank Z. , Miller Alex , Taft Brenton , Allison Jonathan , Abu-Heiba Ahmed , Mahderekal Isaac , Ma Hongbin 
Published: June 2024

Abstract
An oscillating heat pipe (OHP) is a special kind of heat pipe in which the working fluid experiences an oscillatory motion without the need for wick structures or external electrical power input beyond a driving temperature difference. In contrast to traditional heat pipes and thermosyphons, which rely on capillarity or gravitation, OHPs operate based on pressure difference which causes oscillating motion. This oscillation is very important since it is the main reason behind the higher heat flux acquisition capability that OHPs exhibit with respect to other types of heat pipes. However, this oscillation is nondeterministic and thus difficult to model, which hinders the ability to control and design OHPs. Since the invention of OHPs in the early 1990s, many researchers have tried to analyze and predict the oscillating motions in OHPs under different working conditions to enhance their performance and reliability to make them suitable for industrial applications. This review presents the evolution of OHP modeling, as well as mathematical approaches to the analysis of experimental data obtained from OHPs. Furthermore, the machine learning (ML) models applied on OHPs are reviewed.
Effects of Failure Criteria on Quantitatively Determining the Machining Mechanics for CFRP With Different Tool Rake Angles
Authors: Song Chunlei , Jin Xiaoliang 
Published: June 2024

Abstract
The machining mechanics of carbon fiber reinforced polymer (CFRP) materials are influenced by the coupled effects of the workpiece anisotropy, tool edge geometry, and cutting parameters. Predicting the chip formation mechanism is crucial for optimizing cutting parameters, reducing tool wear, and improving efficiency and surface quality. This study quantitatively evaluates the effect of main CFRP failure criteria on the chip formation mechanism in modeling the machining mechanics of CFRP. The results show that the Hashin–Puck and Dávila criteria excel at capturing chip formation across all fiber orientations because of the incorporation of the “internal friction” concept, while others only achieve accurate predictions in specific fiber orientation ranges due to improper shear strength consideration. The sources of the prediction similarities, differences, and limitations of failure criteria are experimentally validated. Sensitivity analyses quantitatively determine the effect of the tool rake angle on the machining energy consumption and cutting forces across the fiber orientation range. This research can be used to select the optimal failure criteria, design proper cutting tool geometry, and inform the cutting parameter choices for CFRP machining operations.
Evolving ω-amine transaminase
At
ATA guided by substrate-enzyme binding free energy for enhancing activity and stability against non-natural substrates
Authors: Qiu Shuai , Ju Cong-Lin , Wang Tong , Chen Jie , Cui Yu-Tong , Wang Lin-Quan , Fan Fang-Fang , Huang Jun 
Published: June 2024

ABSTRACT

In the field of chiral amine synthesis, ω-amine transaminase (ω-ATA) is one of the most established enzymes capable of asymmetric amination under optimal conditions. However, the applicability of ω-ATA toward more non-natural complex molecules remains limited due to its low transamination activity, thermostability, and narrow substrate scope. Here, by employing a combined approach of computational virtual screening strategy and combinatorial active-site saturation test/iterative saturation mutagenesis strategy, we have constructed the best variant M14C3-V5 (M14C3-V62A-V116S-E117I-L118I-V147F) with improved ω-ATA from
Aspergillus terreus
(
At
ATA) activity and thermostability toward non-natural substrate 1-acetylnaphthalene, which is the ketone precursor for producing the intermediate (
R
)-(+)-1-(1-naphthyl)ethylamine [(
R
)-NEA] of cinacalcet hydrochloride, showing activity enhancement of up to 3.4-fold compared to parent enzyme M14C3 (
At
ATA-F115L-M150C-H210N-M280C-V149A-L182F-L187F). The computational tools YASARA, Discovery Studio, Amber, and FoldX were applied for predicting mutation hotspots based on substrate-enzyme binding free energies and to show the possible mechanism with features related to
At
ATA structure, catalytic activity, and stability
in silico
analyses. M14C3-V5 achieved 71.8% conversion toward 50 mM 1-acetylnaphthalene in a 50 mL preparative-scale reaction for preparing (
R
)-NEA. Moreover, M14C3-V5 expanded the substrate scope toward aromatic ketone compounds. The generated virtual screening strategy based on the changes in binding free energies has successfully predicted the
At
ATA activity toward 1-acetylnaphthalene and related substrates. Together with experimental data, these approaches can serve as a gateway to explore desirable performances, expand enzyme-substrate scope, and accelerate biocatalysis.

IMPORTANCE

Chiral amine is a crucial compound with many valuable applications. Their asymmetric synthesis employing ω-amine transaminases (ω-ATAs) is considered an attractive method. However, most ω-ATAs exhibit low activity and stability toward various non-natural substrates, which limits their industrial application. In this work, protein engineering strategy and computer-aided design are performed to evolve the activity and stability of ω-ATA from
Aspergillus terreus
toward non-natural substrates. After five rounds of mutations, the best variant, M14C3-V5, is obtained, showing better catalytic efficiency toward 1-acetylnaphthalene and higher thermostability than the original enzyme, M14C3. The robust combinational variant acquired displayed significant application value for pushing the asymmetric synthesis of aromatic chiral amines to a higher level.
Complete genome sequence of
Serratia ureilytica
KML.E1, a copper-tolerant strain isolated from a disused tungsten mine
Authors: Leung K. M. , Wyatt G. R. , Lai G. K. K. , Leung F. C. C. , Griffin S. D. J. 
Published: June 2024

ABSTRACT

Serratia ureilytica
KML.E1 was recovered from a disused tungsten mine in Hong Kong and can tolerate copper(II) concentrations up to 90 mM. Its complete genome, a single chromosome of 5,094,661 bp (59.68% G+ C), was established through hybrid assembly.
Eyelid sebaceous gland carcinoma: a protocol for a systematic review and meta-analysis of clinicopathological studies of prevalence
Authors: Thagaard Mikkel Straarup , Vest Stine Dahl , Heegaard Steffen , Marcussen Niels 
Published: June 2024

IntroductionSebaceous gland carcinoma (SGC) of the eyelid is an aggressive tumour with the ability to metastasise and an increased morbidity. Controversies regarding the epidemiology of this malignant eyelid tumour is widespread in the scientific literature. Western reports repeatedly describes eyelid SGC as a rare occurring tumour in general, accounting for 1%–3% of all eyelid tumours, however studies from Asia have uncovered a higher frequency of eyelid SGC including 54% of all eyelid tumours in Japan, and 43%–56% in India. We wish to retrieve observational data of eyelid SGC prevalence in proportion to total eyelid tumours, from pathological studies published worldwide to resolve this controversy.Methods and analysisWe will search Ovid Medline, EMBASE, Cochrane Central Register of Controlled Trials, Scopus and Google Scholar to identify published reports on eyelid SGC prevalence proportions, aiming to clarify the incidence of the tumour. We will include observational clinicopathological studies reporting prevalence with confirmed histopathology. No limitations on publication date or language will be applied. Data from the individual studies and study quality will be extracted by two individual reviewers. Study quality will be assessed using the JBI Critical Appraisal Instrument for Studies Reporting Prevalence Data. Raw proportions will be transformed and pooled using a random effects model for meta-analysis. And subgroup analysis according to geography will be performed. If data are deemed unsuitable for a meta-analysis, a narrative synthesis will be presented. We will judge the certainty of evidence and present whether this has an overall effect on the results. The results may shed light on a long-standing academic disparity of the scientific literature.Ethics and disseminationThis systematic review does not require ethical approval. The results of this proposed review will be the subject to a publication in an international peer-reviewed journal within the ophthalmic or pathological specialty.PROSPERO registration numberCRD42023487141.