bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis and Reactivity of 6‐Methyl‐4H‐furo[3,2‐c]pyran‐3,4‐dione.
Authors: Hikem‐Oukacha Djamila , Rachedi Yahia , Hamdi Maamar , Silva Artur M. S. 
Published: May 2011

AbstractKey synthon 3‐bromoacetylpyranone (II) is obtained via a simple and reproducible way.
ChemInform Abstract: A Simple and Green Synthesis of Tetrahydrobenzo[α]‐xanthen‐11‐one Using PEG‐400 as Efficient and Recyclable Reaction Media.
Authors: Shitole Nana V. , Sapkal S. B. , Shingate Bapurao B. , Shingare Murlidhar S. 
Published: May 2011

AbstractTitle compounds (IV) (10 examples) are obtained by a one‐pot three‐component reaction using PEG‐400 as solvent.
ChemInform Abstract: Reactions of 1,3‐Dihalopropan‐2‐ones with Sodium Quinoline‐8‐thiolate.
Authors: Shagun L. G. , Tokareva I. A. , Dorofeev I. A. , Voronkov M. G. 
Published: May 2011

AbstractMechanically activated reaction of the title thiolate (I) with 1,3‐diodopropanone (V) gives the new macroheterocycle (VI), whilst similar reactions of (I) with 1,3‐dichloropropanone yields S‐alkylation products.
ChemInform Abstract: A Copper‐Mediated Cyclization Reaction of Hydrazine with Enediynones Providing Pyrazolo[1,5‐a]pyridines.
Authors: Wu Hung‐Chou , Hwang Long‐Chih , Wu Ming‐Jung 
Published: May 2011

Abstract2,7‐Disubstituted pyrazolopyridines (II) and (IV) are synthesized in moderate to good yields by a cascade cyclization reaction of enediynones (I) and (III) with hydrazine, promoted by copper chloride.
ChemInform Abstract: Synthesis of (2S)‐Isopropyl‐5‐alkynylpyrimidin‐2‐ones: Precursors of β‐Amino Acids.
Authors: Stefani Helio A. , Amaral Monica F. Z. J. , Juaristi Eusebio 
Published: May 2011

AbstractAn efficient synthesis is developed using the Suzuki—Miyaura cross‐coupling of 5‐iodopyrimidinones (I) with alkynyl trifluoroborates.
ChemInform Abstract: Double C—H Activation: The Palladium‐Catalyzed Direct C‐Arylation of Xanthines with Arenes.
Authors: Malakar Chandi C. , Schmidt Dietmar , Conrad Juergen , Beifuss Uwe 
Published: May 2011

AbstractA novel direct approach to biologically important C‐8 arylated xanthines is reported.
ChemInform Abstract: Efficient and Novel One‐Pot Synthesis of Antifungal Active 1‐Substituted‐8‐aryl‐3‐alkyl/aryl‐4H‐pyrazolo[4,5‐f][1,2,4]triazolo [4,3‐b][1,2,4]triazepines Using Solid Support.
Authors: Gupta Monika , Paul Satya , Gupta Rajive 
Published: May 2011

AbstractA simple, efficient and environmentally friendly procedure for the synthesis of title compounds (III) (10 examples) is developed.
ChemInform Abstract: Synthesis and anti‐Plasmodial Activity of 8β,13β‐Dihydroxypodocarpane Derivatives.
Authors: Young Ryan M. , Popplewell Wendy L. , Caira Mino R. , van Zyl Robyn L. , Davies‐Coleman Michael T. 
Published: May 2011

AbstractA variety of 8β,13β‐dihydroxypodocarpane derivatives (V) (8 examples) are synthesized starting from naturally occurring diterpene (+)‐manod.
ChemInform Abstract: Chloropupukeanolides C—E: Cytotoxic Pupukeanane Chlorides with a Spiroketal Skeleton from Pestalotiopsis fici.
Authors: Liu Ling , Bruhn Torsten , Guo Liangdong , Goetz Daniel C. G. , Brun Reto , Stich August , Che Yongsheng , Bringmann Gerhard 
Published: May 2011

AbstractThe compounds show significant cytotoxicity against human tumor cell lines and weak activity against the pathogens of tropical diseases.
ChemInform Abstract: The Synthesis and Biological Evaluation of 1‐C‐Alkyl‐L‐arabinoiminofuranoses, a Novel Class of α‐Glucosidase Inhibitors.
Authors: Natori Yoshihiro , Imahori Tatsushi , Murakami Keiichi , Yoshimura Yuichi , Nakagawa Shinpei , Kato Atsushi , Adachi Isao , Takahata Hiroki 
Published: May 2011

AbstractThe syntheses of arabinoiminofuranoses (X) are performed via asymmetric allylic alkylation [(I)→(III)], ring closing metathesis [(III)→(IV)], and Negishi cross coupling [(V)→(VII)] as the key reactions.
ChemInform Abstract: Synthesis of New C5‐(1‐Substituted‐1,2,3‐triazol‐4 or 5‐yl)‐2′‐deoxyuridines and Their Antiviral Evaluation.
Authors: Montagu Aurelien , Roy Vincent , Balzarini Jan , Snoeck Robert , Andrei Graciela , Agrofoglio Luigi A. 
Published: May 2011

AbstractThe synthesis and antiviral evaluation of a series of C5‐(1,4‐ and 1,5‐disubstituted‐1,2,3‐triazolo)‐nucleoside derivatives are described.
ChemInform Abstract: Catalytic Enantioselective Synthesis of Naturally Occurring Butenolides via hetero‐Allylic Alkylation and Ring Closing Metathesis.
Authors: Mao Bin , Geurts Koen , Fananas‐Mastral Martin , van Zijl Anthoni W. , Fletcher Stephen P. , Minnaard Adriaan J. , Feringa Ben L. 
Published: May 2011

AbstractThe reaction sequence is applied to prepare the (‐)‐whiskey and (‐)‐cognac lactone [cf.
ChemInform Abstract: Divergolides A—D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa‐Macrolide Biosynthesis.
Authors: Ding Ling , Maier Armin , Fiebig Heinz‐Herbert , Goerls Helmar , Lin Wen‐Han , Peschel Gundela , Hertweck Christian 
Published: May 2011

AbstractThe structures of the title compounds point to a common biosynthetic precursor.
ChemInform Abstract: Rhenium‐ and Manganese‐Catalyzed Carbon—Carbon Bond Formation Using 1,3‐Dicarbonyl Compounds and Alkynes
Authors: Kuninobu Yoichiro , Kawata Atsushi , Yudha Salprima S. , Takata Hisatsugu , Nishi Mitsumi , Takai Kazuhiko 
Published: May 2011

AbstractReview: 17 refs.
Structural Investigation of the Naphthyridone Scaffold: Identification of a 1,6‐Naphthyridone Derivative with Potent and Selective Anti‐HIV Activity
Authors: Tabarrini Oriana , Massari Serena , Sancineto Luca , Daelemans Dirk , Sabatini Stefano , Manfroni Giuseppe , Cecchetti Violetta , Pannecouque Christophe 
Published: May 2011

AbstractBuilding upon a large, previously reported series of anti‐HIV 6‐desfluoroquinolones endowed with a peculiar mechanism of action, the inhibition of Tat‐mediated transcription, replacement of the quinolone nucleus with a naphthyridone core was shown to be very productive. In this work, the naphthyridone scaffold was investigated in depth by synthesizing various analogues. This led to the identification of NM13 as the most selective derivative obtained in MT‐4 cells. It is the result of the successful combination of the 1,6‐naphthyridone nucleus and the C7 benzothiazolpiperazine group, which, for the first time, not only grants potent anti‐HIV activity but displays very high selectivity. Further studies aimed at a more thorough investigation of the anti‐HIV profile of this new derivative are in progress.
Removal of Organic Compounds from Water by Using a Gold Nanoparticle–Poly(dimethylsiloxane) Nanocomposite Foam
Authors: Gupta Ritu , Kulkarni Giridhar U. 
Published: May 2011

AbstractA low density, highly compressible, porous foam of poly(dimethylsiloxane) (PDMS) incorporated with Au nanoparticles (10–50 nm) has been synthesized by using a single‐step process with water as a medium. It exhibits high swelling ability (≈600 %) against benzene, toluene, ethylbenzene, and xylene (BTEX)—a property that has been exploited in the removal of oil spills from water. It is resistant to harsh chemical environments. It is also effective against odorous sulfur containing contaminants such as thioanisole. It works repeatedly and efficiently over many cycles. The regeneration of the foam is rather simple: heating in air to 300 °C for short time brings back its original activity. The fascinating properties of Au nanoparticles could be mingled with those of PDMS to provide a sustainable and practical solution for water treatment. It is also demonstrated to work effectively for deodorizing garlic extract with a promise as a food packaging material.
Low‐power, low‐noise, active‐RC band‐pass filters using a ‘lossy’ LP–BP transformation
Authors: Jurisic Drazen , Mijat Neven , Moschytz George S. 
Published: May 2011

SUMMARYA new and straightforward design procedure for simple canonical topologies of allpole, active‐RC, low‐selectivity band‐pass (BP) filters, with low sensitivity to component tolerances is presented. The procedure is primarily intended for discrete‐component, low‐power filter applications using just one amplifier for relatively high‐order filters. The design procedure starts out with an ‘optimized’ low‐pass (LP) prototype filter, yielding an ‘optimized’ BP filter, whereby the wealth of ‘optimized’ single‐amplifier LP filter designs can be exploited. Using a so‐called ‘lossy’ LP–BP transformation, closed‐form design equations for the design of second‐ to eighth‐order, single‐amplifier BP filters are presented. The low sensitivity, low power consumption, and low noise features of the resulting circuits, as well as the influence of the finite gain‐bandwidth product and component spread, are demonstrated for the case of a fourth‐order filter example. The optimized single‐opamp fourth‐order filter is compared with other designs, such as the cascade of optimized Biquads. Using PSpice with a TL081 opamp model, the filter performance is simulated and the results compared and verified with measurements of a discrete‐component breadboard filter using 1% resistors, 1% capacitors, and a TL081 opamp. Copyright © 2011 John Wiley & Sons, Ltd.
Polychromatic flow cytometry identifies novel subsets of circulating cells with angiogenic potential in pediatric solid tumors
Authors: Pradhan Kamnesh R. , Mund Julie A. , Johnson Cynthia , Vik Terry A. , Ingram David A. , Case Jamie 
Published: May 2011

AbstractBackground:Pediatric solid tumors depend upon angiogenesis for their growth and metastases. A new polychromatic flow cytometry (PFC) protocol has revealed circulating cells of hematopoietic and endothelial lineages from the peripheral blood (PB) of healthy individuals, and has defined the different cell types involved in the growth of tumor vasculature that are critical in angiogenesis.Methods:PB was collected from both healthy children and children with different malignant solid tumors and the mononuclear cells (MNCs) were subsequently isolated. PFC was applied and the MNCs were evaluated for proangiogenic and nonangiogenic circulating progenitor cells (CPCs), endothelial colony forming cells (ECFCs), and mature endothelial cells using the markers CD45, CD31, AC133, CD34, CD14, CD235a, CD41a, and a viability marker.Results:ECFCs and CPCs were significantly elevated in patients at day 21 compared to controls. The ratio of proangiogenic to nonangiogenic CPCs was significantly elevated compared to controls at baseline and returned to healthy baseline levels following treatment.Conclusions:We describe the successful identification of these hematopoietic and endothelial progenitor cells in both healthy children and children with solid tumors. In addition, this is a potential discovery of novel predictive biomarkers for future clinical trials. © 2011 International Clinical Cytometry Society
Potential pitfalls for false suspicion of papillary thyroid carcinoma: A Cytohistologic Review of 22 Cases
Authors: Jing Xin , Michael Claire W. 
Published: May 2011

AbstractTo evaluate the diagnostic pitfalls attributing to false suspicious interpretation of papillary thyroid carcinoma (PTC), we performed a retrospective cytohistologic review of thyroid nodules diagnosed as suspicious for papillary carcinoma with histology‐proven false suspicion of PTC. A total of 22 thyroid fine needle aspirates along with the corresponding surgical specimens were reviewed. The presence and/or absence of PTC‐associated morphologic features and their mimics were evaluated. One aspirate showed papillary‐like fragments with honeycomb architecture. One aspirate contained rare syncytial‐type fragments which were accompanied by honeycomb sheets of follicular cells and moderate amount of colloid. Intranuclear grooves presented occasionally in virtually all 22 aspirates. The grooves were noted mainly within round nuclei and appeared thin and/or incomplete. Rare intranuclear pseudoinclusions were detected in one otherwise benign‐appearing aspirates. Eight aspirates contained various numbers of histiocytes, as well as atypical polygonal, epithelioid, elongate, or spindle cells in which intranuclear grooves were occasionally seen. Conspicuous fragments of fibrocollagenous tissue with entrapped follicular cells were detected in one aspirate. The corresponding histological specimen revealed counterpart of the cytological findings described. Other features associated with PTC were inconspicuous. The findings demonstrated that the following factors may contribute to the false suspicion of PTC: (1) misinterpretation of papillary‐like tissue fragments with honeycomb arrangement and fragments offibrocollagenous tissue with entrapped follicular cells; (2) overinterpretation of suboptimal intranuclear grooves and rare intranuclear pseudoinclusion in the absence of the other features of PTC; (3) misinterpretation of the polygonal, epithelioid, elongate, or spindle cells that actually represented atypical cyst lining cells. Diagn. Cytopathol. 2012;40:E74–E79. © 2011 Wiley Periodicals, Inc.
Cytohistological study of clear cell carcinoma of kidney with special reference to nuclear grading and tumor size
Authors: Mondal Santosh Kumar 
Published: May 2011

AbstractSeveral prognostic indicators have shown to predict patients' survival in clear cell carcinoma of kidney. Among these, Fuhrman nuclear grading and tumor size are believed to be two important prognostic factors. The aim of this study was to evaluate the efficacy of fine needle aspiration cytology (FNAC) to classify the clear cell renal cell carcinoma (CRCC) according to nuclear grade and tumor size. A total of 24 patients (15 males, 9 females) suffering from CRCC were included in this study over a period of 5 years (January, 2005 to December, 2009). A preoperative cytologic diagnosis was made by computed tomography guided FNAC and histologic correlation was made after surgery. Cytologic diagnoses were nuclear grade 1 or G1 (four cases), nuclear grade 2 or G2 (11 cases), nuclear grade 3 or G3 (six cases) and nuclear grade 4 or G4 (three cases). Radical nephrectomies were done during surgery and most of the specimens were from right side (18/24). Upper pole was commonly involved by the tumor (19/24). Low nuclear grade lesions (G1 and G2) were commonly seen with tumor size up to 5 cm and high nuclear grade lesions (G3 and G4) were common when tumor was >5 cm in size. After cytohistologic correlation, diagnostic accuracy of FNAC was found to be 87.5% in this study. FNAC has high diagnostic accuracy in CRCC and highly dependable procedure to classify these tumors according to its nuclear grade. Both the nuclear grading and tumor size can be used to predict the clinical outcome in these patients. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Site‐Selective Chemical Reaction on Flexible Polymer Films for Tin Oxide Nanosheet Patterning
Authors: Masuda Yoshitake , Ohji Tatsuki , Kato Kazumi 
Published: May 2011

AbstractSite‐selective tin oxide deposition from aqueous solution was performed on super‐hydrophilic surfaces. The chemical reaction and nucleation accelerated on hydroxy groups to form tin oxide nanosheets. Consequently, two‐dimensional patterns of tin oxide nanosheets were fabricated on poly(ethylene terephthalate) (PET) films coated with indium tin oxide (ITO). Tin oxide sheets grew to 100–300 nm in‐plane size and 5–10 nm thickness. Hydrophobic areas of the films suppressed formation of tin oxide structures. The site‐selective chemical reaction can be applied to allow precise control of chemical reactions, surface coating, and two‐dimensional patterning of tin oxide nanostructures for future devices.
Adsorption of Glucose Oxidase to 3‐D Scaffolds of Carbon Nanotubes: Analytical Applications
Authors: Nejadnik M. Reza , Deepak Francis L. , Garcia Carlos D. 
Published: May 2011

AbstractThis study is the first to focus on the potential use of carbon nanotube (CNT) scaffolds as enzyme immobilization substrates for analytical purposes. Besides all the well‐known advantages of CNT, three‐dimensional scaffolds can significantly increase the amount of enzymes adsorbed per unit area, preserve the catalytic activity of the adsorbed molecules, and allow effective exposure to substrates present in the adjacent medium. Additionally, our results indicate that the sensitivity of analytical probes based on enzyme‐loaded CNT scaffolds is proportional to the thickness of the scaffold providing 3‐fold sensitivity improvements with respect to the control surfaces.
Loss of heterozygosity proximal to the M6P/IGF2R locus is predictive for the presence of disseminated tumor cells in the bone marrow of ovarian cancer patients before and after chemotherapy
Authors: Kuhlmann Jan Dominik , Schwarzenbach Heidi , Otterbach Friedrich , Heubner Martin , Wimberger Pauline , Worm Karl‐Heinz , Kimmig Rainer , Kasimir‐Bauer Sabine 
Published: May 2011

AbstractDisseminated tumor cells (DTC) in the bone marrow (BM) are present in about 35% of ovarian cancers before surgery and after chemotherapy and are associated with worse prognosis. A molecular biomarker in the primary tumor predicting tumor cell spread would be highly desirable. The purpose of the study was to investigate loss of heterozygosity (LOH) in primary ovarian tumors at four ovarian cancer‐relevant chromosomal loci involved in apoptosis, platinum sensitivity, or DNA‐repair, to assess the prognostic value of LOH and to correlate LOH with DTC occurrence before surgery and after chemotherapy. Primary tumor DNA of 88 patients was analyzed for LOH at four polymorphic microsatellite markers using PCR‐based fluorescence microsatellite analysis. BM aspirates were analyzed for DTC by immunocytochemistry using the pan‐cytokeratin antibody A45‐B/B3. LOH at the entire marker set correlated with tumor grading (P = 0.0001) and histology (P = 0.004). LOH at marker D10S1765 correlated with FIGO stage (P = 0.046) and grading (P = 0.05), whereas LOH at D17S855 significantly associated with grading (P = 0.023) and histology (P = 0.012), respectively. DTC were detected in 49% of patients before surgery and in 50% of patients after chemotherapy. Interestingly, LOH proximal to D6S1581 significantly correlated with DTC presence before surgery (P = 0.05) and after chemotherapy (P = 0.022). Conclusively, our data suggest that allelic loss at D6S1581 (proximal to M6P/IGF2R locus) serves as a molecular biomarker for the presence of DTC in the BM before and after chemotherapy. © 2011 Wiley‐Liss, Inc.
Effects of non‐steroidal anti‐inflammatory drug treatments on cognitive decline vary by phase of pre‐clinical Alzheimer disease: findings from the randomized controlled Alzheimer's Disease Anti‐inflammatory Prevention Trial
Authors: Leoutsakos Jeannie‐Marie S. , Muthen Bengt O. , Breitner John C.S. , Lyketsos Constantine G. 
Published: May 2011

ObjectiveWe examined the effects of non‐steroidal anti‐inflammatory drugs on cognitive decline as a function of phase of pre‐clinical Alzheimer disease.MethodsGiven recent findings that cognitive decline accelerates as clinical diagnosis is approached, we used rate of decline as a proxy for phase of pre‐clinical Alzheimer disease. We fit growth mixture models of Modified Mini‐Mental State (3MS) Examination trajectories with data from 2388 participants in the Alzheimer's Disease Anti‐inflammatory Prevention Trial and included class‐specific effects of naproxen and celecoxib.ResultsWe identified three classes: “no decline”, “slow decline”, and “fast decline”, and examined the effects of celecoxib and naproxen on linear slope and rate of change by class. Inclusion of quadratic terms improved fit of the model (−2 log likelihood difference: 369.23;p < 0.001) but resulted in reversal of effects over time. Over 4 years, participants in the slow‐decline class on placebo typically lost 6.6 3MS points, whereas those on naproxen lost 3.1 points (p‐value for difference: 0.19). Participants in the fast‐decline class on placebo typically lost 11.2 points, but those on celecoxib first declined and then gained points (p‐value for difference from placebo: 0.04), whereas those on naproxen showed a typical decline of 24.9 points (p‐value for difference from placebo: <0.0001).ConclusionsOur results appeared statistically robust but provided some unexpected contrasts in effects of different treatments at different times. Naproxen may attenuate cognitive decline in slow decliners while accelerating decline in fast decliners. Celecoxib appeared to have similar effects at first but then attenuated change in fast decliners. Copyright © 2011 John Wiley & Sons, Ltd.
Integration between a percutaneous implant and the porcine small bowel
Authors: Johansson Martin L. , Thomsen Peter , Hultén Leif , Halvorsen Per Steinar , Fosse Erik , Edwin Bjørn 
Published: May 2011

AbstractInflammatory bowel diseases, cancer or trauma may require removal of all or part of the intestines, leaving the patient with a need to wear external stoma appliances for collection of bowel contents. By connecting the small bowel to a percutaneous port, equipped with a sealing lid, a fully continent and leak proof stoma can be created without a need for permanently wearing stoma appliance. The prerequisites for a connection between a permanent, transabdominal implant and a visceral organ are largely unexplored. Stoma ports made of titanium were implanted in the abdominal wall of domestic pigs and a branch of distal ileum was inserted through the ports. After being followed for 1–3 weeks, the ports were removed and subjected to histological evaluation to study the influence of their shape, structure, and position on the tissue response. Particular focus was attended to the attachment of the ileal serosal surface to the implants inner structure consisting of a titanium mesh. Macroscopic examination revealed fistulas and formation of abscesses in 4 of 11 the retrieved implants. Histological examination revealed regenerated and well‐vascularized collagenous tissue around the mesh structure inside the implant. The integration was complete or partial for 10 of 11 ports. Despite various degrees of inflammation and tissue ingrowth, it was demonstrated for the first time that the serosal surface of ileum was firmly attached to the internal structure of the implant. These experiments provide a basis for optimization of the implant and surgical procedure before long‐term functional animal experiments. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
Abdominal sensory equipment involved in external host discrimination in a solitary parasitoid wasp
Authors: Goubault MarlÈne , Cortesero Anne Marie , Paty Chrystelle , Fourrier Julie , Dourlot Sonia , Ralec Anne Le 
Published: May 2011

AbstractAlready parasitized hosts are often of poorer quality than healthy hosts. It is therefore usually advantageous for parasitoid females to recognize and reject them. Parasitized hosts can be identified on the basis of various physical or chemical marks present on the surface or inside the hosts or their surroundings in the case of concealed host. Here we studied host discrimination behaviors of females of a certain population of Pachycrepoideus vindemmiae, a solitary ectoparasitoid, which are known to reject large‐sized parasitized hosts after an abdominal examination of their surface. We first investigated females' recognition behaviors of host parasitism status when confronted to small‐sized hosts (Drosophila melanogaster pupae) as host size may influence the use of different cues for host selection. We showed that, in such a situation, females also discriminate parasitized hosts after an external host exploration with the tip of their ovipositor sheath (third valvulae). We then described the sense organs present on the different parts of the ovipositor by means of scanning and transmission electron microscopy analysis. As the extremity of the third valvulae bears only one type of sensilla that appears to be chemoreceptors, we considered these sensilla as highly likely to be involved in host discrimination in P. vindemmiae. To our knowledge, this is the first time that receptors located on the ovipositor sheath are described as implicated in host discrimination in parasitoid wasps. We discuss potential chemical markers that might be detected by these receptors. Microsc. Res. Tech., 2011. © 2011 Wiley Periodicals, Inc.