bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromothripsis in myeloid malignancies
Authors: Chen Chien-Yuan 
Published: May 2024

AbstractChromothripsis refers to massive genomic rearrangements developed during a catastrophic event. In total acute myeloid leukemia (AML), the incidence of chromothripsis ranges from 0 to 6.6%, in cases of complex karyotype AML, the incidence of chromothripsis ranges from 27.3 to 100%, whereas in cases of AML with TP53 mutations, the incidence ranges from 11.1 to 90%. For other types of malignancies, the incidence of chromothripsis also varies, from 0 to 10.5% in myelodysplastic syndrome to up to 61.5% in cases of myelodysplastic syndrome with TP53 mutations.Chromothripsis is typically associated with complex karyotypes and TP53 mutations, and monosomal karyotypes are associated with the condition. ERG amplifications are frequently noted in cases of chromothripsis, whereas MYC amplifications are not. Moreover, FLT3 and NPM1 mutations are negatively associated with chromothripsis. Chromothripsis typically occurs in older patients with AML with low leukocyte counts and bone marrow blast counts. Rare cases of patients with chromothripsis who received intensive induction chemotherapy revealed low response rates and poor overall prognosis. Signal pathways in chromothripsis typically involve copy number gain and upregulation of oncogene gene sets that promote cancer growth and a concomitant copy number loss and downregulation of gene sets associated with tumor suppression functions.Patients with chromothripsis showed a trend of lower complete remission rate and worse overall survival in myeloid malignancy. Large-scale studies are required to further elucidate the causes and treatments of the condition.
Dietary carbohydrate quality index and incidence of obesity-related cancers in the “Seguimiento Universidad De Navarra” (SUN) prospective cohort
Authors: Olmedo M. , Santiago S. , Romanos-Nanclares A. , Aramendia-Beitia J. M. , Sanchez-Bayona R. , Bes-Rastrollo M. , Martinez-Gonzalez M. A. , Toledo E. 
Published: May 2024

Summary
Purpose
The quality, rather than the quantity, of carbohydrate intake may play a major role in the etiology of obesity-related cancers (ORCs). We assessed the association between a previously defined carbohydrate quality index (CQI) and the risk of developing ORCs in the “Seguimiento Universidad de Navarra” (SUN) cohort.

Methods
A total of 18,446 Spanish university graduates [mean age 38 years (SD 12 years), 61% women, mean BMI 23.5 kg/m2 (SD 3.5 kg/m2)], with no personal history of cancer, were followed-up. Baseline CQI was assessed summing quintiles of four previously defined criteria: high dietary fiber intake, low glycemic index (GI), high whole-grain: total-grain carbohydrates ratio and high solid carbohydrates: total carbohydrates ratio. Participants were classified into tertiles of their total CQI. Incident ORCs were confirmed by an oncologist using medical records and by querying the National Death Index blindly to dietary exposures.

Results
During a median follow-up of 13.7 years, 269 incident cases of ORC were confirmed. A higher CQI was inversely associated with ORC incidence [multivariable-adjusted hazard ratio (HR) for the upper (T3) versus the lowest tertile (T1) of 0.68 (95% CI: 0.47–0.96), p for trend = 0.047]. Particularly, higher dietary fiber intake was inversely associated with ORC, HRT3 vs. T1=0.57 (95% CI 0.37–0.88 p for trend = 0.013).

Conclusion
In this prospective Mediterranean cohort, an inverse association between a better global quality of carbohydrate intake and the risk of ORCs was found. Strategies for cancer prevention should promote a higher quality of carbohydrate intake.
Targeting Gαi2 in neutrophils protects from myocardial ischemia reperfusion injury
Authors: Köhler David , Leiss Veronika , Beichert Lukas , Killinger Simon , Grothe Daniela , Kushwaha Ragini , Schröter Agnes , Roslan Anna , Eggstein Claudia , Focken Jule , Granja Tiago , Devanathan Vasudharani , Schittek Birgit , Lukowski Robert , Weigelin Bettina , Rosenberger Peter , Nürnberg Bernd , Beer-Hammer Sandra 
Published: May 2024

AbstractNeutrophils are not only involved in immune defense against infection but also contribute to the exacerbation of tissue damage after ischemia and reperfusion. We have previously shown that genetic ablation of regulatory Gαi proteins in mice has both protective and deleterious effects on myocardial ischemia reperfusion injury (mIRI), depending on which isoform is deleted. To deepen and analyze these findings in more detail the contribution of Gαi2 proteins in resident cardiac vs circulating blood cells for mIRI was first studied in bone marrow chimeras. In fact, the absence of Gαi2 in all blood cells reduced the extent of mIRI (22,9% infarct size of area at risk (AAR) Gnai2−/− → wt vs 44.0% wt → wt; p < 0.001) whereas the absence of Gαi2 in non-hematopoietic cells increased the infarct damage (66.5% wt → Gnai2−/−vs 44.0% wt → wt; p < 0.001). Previously we have reported the impact of platelet Gαi2 for mIRI. Here, we show that infarct size was substantially reduced when Gαi2 signaling was either genetically ablated in neutrophils/macrophages using LysM-driven Cre recombinase (AAR: 17.9% Gnai2fl/fl LysM-Cre+/tg vs 42.0% Gnai2fl/fl; p < 0.01) or selectively blocked with specific antibodies directed against Gαi2 (AAR: 19.0% (anti-Gαi2) vs 49.0% (IgG); p < 0.001). In addition, the number of platelet-neutrophil complexes (PNCs) in the infarcted area were reduced in both, genetically modified (PNCs: 18 (Gnai2fl/fl; LysM-Cre+/tg) vs 31 (Gnai2fl/fl); p < 0.001) and in anti-Gαi2 antibody-treated (PNCs: 9 (anti-Gαi2) vs 33 (IgG); p < 0.001) mice. Of note, significant infarct-limiting effects were achieved with a single anti-Gαi2 antibody challenge immediately prior to vessel reperfusion without affecting bleeding time, heart rate or cellular distribution of neutrophils. Finally, anti-Gαi2 antibody treatment also inhibited transendothelial migration of human neutrophils (25,885 (IgG) vs 13,225 (anti-Gαi2) neutrophils; p < 0.001), collectively suggesting that a therapeutic concept of functional Gαi2 inhibition during thrombolysis and reperfusion in patients with myocardial infarction should be further considered.
Is neoadjuvant chemotherapy necessary for T2N0-1M0 hormone receptor-positive/HER2-negative breast cancer patients undergoing breast-conserving surgery?
Authors: Liu Dandan , Chang Lidan , Hao Qian , Ren Xueting , Liu Peinan , Liu Xingyu , Wei Yumeng , Wang Meng , Wu Hao , Kang Huafeng , Lin Shuai 
Published: May 2024

Abstract
Introduction
For HR-positive/HER2-negative patients who can undergo breast-conserving surgery (BCS) but have a tumor size of 2–5 cm or 1–3 lymph node metastases, neoadjuvant chemotherapy (NAC) is still controversial.

Methods
Patients with T2N0-1M0 HR-positive/HER2-negative BC who underwent BCS between 2010 and 2017 were selected from the SEER database. Propensity score matching (PSM) was used to minimize the influence of confounding factors. The overall survival (OS) and breast cancer-specific survival (BCSS) of patients were estimated by Kaplan‒Meier curves and Cox proportional hazard models. Independent prognostic factors were included to construct a nomogram prediction model.

Results
A total of 6475 BC patients were enrolled, of whom 553 received NAC and 5922 received adjuvant chemotherapy (AC). In the T2N0-1M0 population and T2N1M0 subgroup, AC patients before PSM had better OS and BCSS than NAC patients. After PSM, there was no significant difference in OS or BCSS between the two groups. However, in the T2N0M0 subgroup, there was no difference in survival between the AC and NAC groups before and after PSM. Stratified analysis revealed that for complete response (CR) patients, survival was roughly equivalent between the NAC and AC groups. However, the survival of no response (NR) and partial response (PR) patients was significantly worse than that of AC patients. Cox analysis revealed that radiotherapy after BCS was an independent protective factor for OS. NAC is an independent risk factor for NR and PR patients. The nomogram has good prediction efficiency.

Conclusion
NAC before BCS is not necessary for T2N0-1M0 HR-positive/HER2-negative BC patients.
Physiological meaning of bimodal tree growth-climate response patterns
Authors: Büntgen Ulf , Esper Jan 
Published: May 2024

AbstractCorrelation coefficients are widely used to identify and quantify climate signals in proxy archives. Significant relationships between tree-ring chronologies and meteorological measurements are typically applied by dendroclimatologists to distinguish between more or less relevant climate variation for ring formation. While insignificant growth-climate correlations are usually found with cold season months, we argue that weak relationships with high summer temperatures not necessarily disprove their importance for xylogenesis. Here, we use maximum latewood density records from ten treeline sites between northern Scandinavia and southern Spain to demonstrate how monthly growth-climate correlations change from narrow unimodal to wide bimodal seasons when vegetation periods become longer and warmer. Statistically meaningful relationships occur when minimum temperatures exceed ‘biological zero’ at around 5° C. We conclude that the absence of evidence for statistical significance between tree growth and the warmest summer temperatures at Mediterranean sites is no evidence of absence for the physiological importance of high summer temperatures for ring formation. Since correlation should never be confused with causation, statistical values require mechanistic understanding, and different interpretations are needed for insignificant correlations within and outside the growing season.
Normalized solutions to Schrödinger equations in the strongly sublinear regime
Authors: Mederski Jarosław , Schino Jacopo 
Published: May 2024

AbstractWe look for solutions to the Schrödinger equation $$\begin{aligned} -\Delta u + \lambda u = g(u) \quad \text {in } \mathbb {R}^N \end{aligned}$$

-
Δ
u
+
λ
u
=
g

(
u
)

in

R

N

coupled with the mass constraint $$\int _{\mathbb {R}^N}|u|^2\,dx = \rho ^2$$

∫

R

N

|
u
|

2

d
x
=

ρ
2

, with $$N\ge 2$$

N
≥
2

. The behaviour of g at the origin is allowed to be strongly sublinear, i.e., $$\lim _{s\rightarrow 0}g(s)/s = -\infty $$

lim

s
→
0

g

(
s
)

/
s
=
-
∞

, which includes the case $$\begin{aligned} g(s) = \alpha s \ln s^2 + \mu |s|^{p-2} s \end{aligned}$$

g

(
s
)

=
α
s
ln

s
2

+
μ

|
s
|

p
-
2

s

with $$\alpha > 0$$

α
>
0

and $$\mu \in \mathbb {R}$$

μ
∈
R

, $$2 < p \le 2^*$$

2
<
p
≤

2
∗

properly chosen. We consider a family of approximating problems that can be set in $$H^1(\mathbb {R}^N)$$

H
1

(

R

N

)

and the corresponding least-energy solutions, then we prove that such a family of solutions converges to a least-energy one to the original problem. Additionally, under certain assumptions about g that allow us to work in a suitable subspace of $$H^1(\mathbb {R}^N)$$

H
1

(

R

N

)

, we prove the existence of infinitely, many solutions.
Parental mental disorders in patients with comorbid schizophrenia and obsessive–compulsive disorder: a nationwide family-link study
Authors: Hsu Tien-Wei , Tsai Shih-Jen , Bai Ya-Mei , Cheng Chih-Ming , Su Tung-Ping , Chen Tzeng-Ji , Liang Chih-Sung , Chen Mu-Hong 
Published: May 2024

AbstractSchizophrenia is highly comorbid with obsessive–compulsive disorder (OCD); both conditions share numerous pathophysiological etiologies. We, thus, examined the risk of mental disorders in the parents of probands with schizophrenia, OCD, or both conditions. Between 2001 and 2011, we enrolled a nationwide cohort of 69,813 patients with schizophrenia, OCD, or both. The control cohort included 698,130 individuals matched for demographics. Poisson regression models were employed to examine the risk of six mental disorders in their parents, including schizophrenia, bipolar disorder, depressive disorder, OCD, alcohol use disorder, and substance use disorder. We stratified patients into schizophrenia-only, OCD-only, and dual-diagnosis groups, and the dual-diagnosis group was further divided into schizophrenia-first, OCD-first, and simultaneously diagnosed groups. Compared with controls, the schizophrenia, OCD, and dual-diagnosis groups had higher risks for the six mental disorders in their parents (range of odds ratio [OR] 1.50–7.83). The sub-analysis of the dual-diagnosis group showed that the schizophrenia-first, OCD-first, and simultaneously diagnosed groups had higher odds for schizophrenia, bipolar disorder, depressive disorder, and OCD (range of OR 1.64–6.45) in their parents than the control group; the simultaneously diagnosed and OCD-first diagnosed groups had a higher odds of parental substance use disorder, while the schizophrenia-first diagnosed group had a higher odds of parental alcohol use disorder. The interrelationship between OCD and schizophrenia is linked to bipolar disorder, depressive disorder, alcohol use disorder, and substance use disorder. The results have implications for mental health policy and future research.
Acute-to-chronic subdural hematoma: radiographic and clinical progression from acute subdural hematoma
Authors: Liebert Adrian , Hirschmann Emily , Eibl Thomas , Hammer Alexander , Steiner Hans-Herbert , Schebesch Karl-Michael , Ritter Leonard 
Published: May 2024

AbstractIntroduction: The pathogenesis of chronic subdural hematoma (CSDH) has not been completely understood. However, different mechanisms can result in space-occupying subdural fluid collections, one pathway can be the transformation of an original trauma-induced acute subdural hematoma (ASDH) into a CSDH. Materials and Methods: All patients with unilateral CSDH, requiring burr hole trephination between 2018 and 2023 were included. The population was distributed into an acute-to-chronic group (group A, n = 41) and into a conventional group (group B, n = 282). Clinical and radiographic parameters were analyzed. In analysis A, changes of parameters after trauma within group A are compared. In analysis B, parameters between the two groups before surgery were correlated. Results: In group A, volume and midline shift increased significantly during the progression from acute-to-chronic (p < 0.001, resp.). Clinical performance (modified Rankin scale, Glasgow Coma Scale) dropped significantly (p = 0.035, p < 0.001, resp.). Median time between trauma with ASDH and surgery for CSDH was 12 days. Patients treated up to the 12th day presented with larger volume of ASDH (p = 0.012). Before burr hole trephination, patients in group A presented with disturbance of consciousness (DOC) more often (p = 0.002), however less commonly with a new motor deficit (p = 0.014). Despite similar midline shift between the groups (p = 0.8), the maximal hematoma width was greater in group B (p < 0.001). Conclusion: If ASDH transforms to CSDH, treatment may become mandatory early due to increase in volume and midline shift. Close monitoring of these patients is crucial since DOC and rapid deterioration is common in this type of SDH.
Maximizing the economic benefit for cable yarding timber harvesting operations by spatially optimizing tree selection
Authors: Sforza Francesco , Starke Michael , Dietsch Patrick , Thür Peter , Lingua Emanuele , Ziesak Martin 
Published: May 2024

AbstractThe efficiency of forest logging operations can be strongly affected by the layout of the harvesting pattern, which is usually based on silvicultural constraints and technical feasibility. Specifically, individual tree volume and the spatial distribution of trees significantly impact the overall harvesting performance. Spatial optimization of tree selection at the forest stand level may improve timber harvest efficiency by maximizing key performance indicators, such as the economic benefit, under given operational and silvicultural constraints. In this study, we applied two harvesting operation-optimization approaches based on integer programming for uphill cable yarding operations in mountain areas, including tree selection and load maximization. The first approach involves tree selection based on single tree harvest, while the second one performs tree selection based on tree clusters harvest per work cycle. As input elements a productivity model, derived by time-motion study with a Mounty MT50-2 and individual tree parameters extracted from high-resolution airborne laser scanning data, were prepared. Single tree information was further rated by financial value, and subsequently combined with the productivity model, allowing a detailed breakdown of operational costs. The results showed that optimizing the tree selection while respecting the allowable cut timber volume established in the harvesting plan can improve the efficiency of forest operations. The cluster approach was shown to be more efficient in terms of economic benefit compared to the actual selection, with an increase of 24.94%. However, the single tree approach resulted in a decrease of economic benefit compared to the actual selection, with a decrease of 22.85%.
Animal health and welfare as a public good: what do the public think?
Authors: Clark B. , Proctor A. , Boaitey A. , Mahon N. , Hanley N. , Holloway L. 
Published: May 2024

AbstractThis paper presents a novel perspective on an evolving policy area. The UK’s withdrawal from the EU has led to the creation of a new Agriculture Act and proposals for significant changes to the way farming subsidies are structured in England. Underpinned by a ‘public money for public goods’ approach, where public goods are those outputs from the farm system which are not rewarded by markets, yet which provide benefits to many members of society. New schemes include the Animal Health and Welfare Pathway, where certain aspects of farm animal health and welfare (FAHW) will be subsidised through government support, raising a much-debated issue in the literature regarding the representation of FAHW as a public good. For policy to be responsive to societal demands and accountable to citizens, understanding public attitudes and preferences towards FAHW as a public good, and how the public might prioritise this in relation to a wider suite of environmental public goods from farming, is important. An online survey of 521 members of the UK public was conducted and analysed with descriptive statistics and ordered logistic regression. Findings reveal low awareness of the changing agricultural policy context, but strong support for public money being used to provide public goods, particularly for FAHW. Findings also indicate a need for more effective public communication of farming and FAHW issues from farming stakeholders to ensure public policy in this domain is responsive and accountable to its citizens. Further work is needed to inform future debates and engagement surrounding FAHW, including through which combination of funding mechanisms (public or private) it is provided.
Inquiring Value: The Pragmatist Turn in Business Ethics
Authors: Rydenfelt Henrik 
Published: May 2024

Abstract
30 years ago, R. Edward Freeman levied an influential challenge against the “separation thesis”, which maintains that ethical and business concerns are distinct and separable. However, achieving an integration of empirical and normative research continues to pose significant challenges. In this article, it is argued that the tradition of philosophical pragmatism offers a pathway to bridge this divide. While Freeman’s critique is rooted in pragmatism, it falls short of fully embracing the pragmatist turn as advocated by Charles S. Peirce and John Dewey, who extended the methodologies of empirical inquiry to ethical issues. Typically, this pragmatist turn has been sidelined due to the formidable objection that norms and values cannot be empirically confirmed nor disconfirmed. This objection is critically examined, arguing that it is largely based on conceptions of science associated with positivism and logical empiricism, effectively challenged by pragmatism. Embracing a pragmatist perspective, it is argued, can substantially enhance both theoretical and empirical research within business ethics. This approach entails integrating observations that pertain to the values, norms and responsibilities of businesses. Conversely, with a comprehensive understanding of the theoretical underpinnings of such proposals, observations can help determine which ethical theories and perspectives best accommodate empirical findings. Additionally, pragmatism presents a novel approach to the role of business in society, enabling businesses to engage in democratic processes of inquiry into value.
Low-energy Earth–Moon transfers via Theory of Functional Connections and homotopy
Authors: Campana C. T. , Merisio G. , Topputo F. 
Published: May 2024

AbstractNumerous missions leverage the weak stability boundary in the Earth–Moon–Sun system to achieve a safe and cost-effective access to the lunar environment. These transfers are envisaged to play a significant role in upcoming missions. This paper proposes a novel method to design low-energy transfers by combining the recent Theory of Functional Connections with a homotopic continuation approach. Planar patched transfer legs within the Earth–Moon and Sun–Earth systems are continued into higher-fidelity models. Eventually, the full Earth–Moon transfer is adjusted to conform to the dynamics of the planar Earth–Moon Sun-perturbed, bi-circular restricted four-body problem. The novelty lies in the avoidance of any propagation during the continuation process and final convergence. This formulation is beneficial when an extensive grid search is performed, automatically generating over 2000 low-energy transfers. Subsequently, these are optimized through a standard direct transcription and multiple shooting algorithm. This work illustrates that two-impulse low-energy transfers modeled in chaotic dynamic environments can be effectively formulated in Theory of Functional Connections, hence simplifying their overall design process. Moreover, its synergy with a homotopic continuation approach is demonstrated.