bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Alpha-Synuclein in Synucleinopathy: Impact on Lipid Regulation at Mitochondria–ER Membranes
Authors: Barbuti Peter A. , Guardia-Laguarta Cristina , Yun Taekyung , Chatila Zena K. , Flowers Xena. , Santos Bruno FR. , Larsen Simone B. , Hattori Nobutaka , Bradshaw Elizabeth , Dettmer Ulf , Fanning Saranna , Vilas Manon , Reddy Hasini , Teich Andrew F. , Krüger Rejko , Area-Gomez Estela , Przedborski Serge 
Published: June 2024

AbstractThe protein alpha-synuclein (αSyn) plays a critical role in the pathogenesis of synucleinopathy, which includes Parkinson’s disease and multiple system atrophy, and mounting evidence suggests that lipid dyshomeostasis is a critical phenotype in these neurodegenerative conditions. Previously, we identified that αSyn localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs), temporary functional domains containing proteins that regulate lipid metabolism, including the de novo synthesis of phosphatidylserine. In the present study, we have analyzed the lipid composition of postmortem human samples, focusing on the substantia nigra pars compacta of Parkinson’s disease and controls, as well as three less affected brain regions of Parkinson’s donors. To further assess synucleinopathy-related lipidome alterations, similar analyses were performed on the striatum of multiple system atrophy cases. Our data show region-and disease-specific changes in the levels of lipid species. Specifically, our data revealed alterations in the levels of specific phosphatidylserine species in brain areas most affected in Parkinson’s disease. Some of these alterations, albeit to a lesser degree, are also observed multiples system atrophy. Using induced pluripotent stem cell-derived neurons, we show that αSyn contributes to regulating phosphatidylserine metabolism at MAM domains, and that αSyn dosage parallels the perturbation in phosphatidylserine levels. Our results support the notion that αSyn pathophysiology is linked to the dysregulation of lipid homeostasis, which may contribute to the vulnerability of specific brain regions in synucleinopathy. These findings have significant therapeutic implications.Significance StatementSynucleinopathy is a complex group of neurodegenerative disorders whose causes and underlying mechanisms remain unknown. In this work, we examined synucleinopathy postmortem brain samples and patient-derived neuron models and identified the functional impairment of the mitochondrial-associated endoplasmic reticulum membrane (MAM) domain, which facilitates lipid regulation. The protein alpha-synuclein is associated with synucleinopathy and increasing levels result in the mislocalization of this protein and the disruption of MAM domains, which, in turn, results in lipid and membrane composition alterations. Specifically, we report that increased alpha-synuclein expression impairs the regulation of phosphatidylserine synthase 2 and the levels of phosphatidylserine in cellular membranes from affected cells. Our study offers mechanistic insight tying alpha-synuclein pathology and lipid dysregulation as seminal factors in synucleinopathy, which may have pathogenic and therapeutic implications.
Comorbid autism spectrum disorder and borderline personality disorder: case conceptualization and treatment implications
Authors: Allman Madeleine , Kerr Sophie , Roldan Carmelo Ismael , Harris Geri Maria , Harris Gerald E. 
Published: June 2024

Purpose
Autism spectrum disorder (ASD) and borderline personality disorder (BPD) are complex disorders characterized by pervasive symptoms of rigidity, emotion dysregulation and social cognitive difficulties. Comorbid ASD and BPD are recognized emerging clinical problem that may be challenging to treat.

Design/methodology/approach
The authors present a case study of a young person in the authors’ assessment clinic diagnosed with BPD and ASD who had received standard dialectical behavior therapy (DBT) with modest effects. The authors provide ASD-informed recommendations for continued DBT treatment.

Findings
The de-identified patient described in this case report met full criteria for ASD and BPD. The patient’s cognitive, behavioral, social and personality functioning are described in detail.

Practical implications
Other practitioners seeking to treat this complex comorbidity may make use of the authors’ treatment recommendations for their patients. The authors underscore the importance of individualized treatment planning and hope the authors’ exemplar will be useful to others.

Originality/value
Several evidence-based treatments exist for ASD and BPD symptom reduction. However, to the best of the authors’ knowledge, no current treatments exist for comorbid ASD and BPD to target emotion dysregulation in individuals with restricted and repetitive interests and behaviors and disturbances in social and communication domains.
The association between institutional monitoring, political connections and audit report lag: evidence from the Malaysian capital market
Authors: Qasem Ameen 
Published: June 2024

PurposeThis study aims to examine the association between institutional investors’ ownership (IOW), politically connected firms (POCF) and audit report lag (AUDRL).Design/methodology/approachThis study employs a feasible generalised least squares (FGLS) model for panel data to examine the association between IOW, POCF and AUDRL for Malaysian publicly listed companies.FindingsThe findings reveal a statistically significant negative relationship between IOW and AUDRL, with this negative relationship being more pronounced amongst POCF. Additionally, the results demonstrate that the relationship between IOW and AUDRL varies depending on the domicile of IIs (local vs. foreign). Specifically, local institutional investors exhibit a negative and statistically significant relationship with AUDRL, whilst foreign institutional investors show a positive and statistically significant relationship with AUDRL.Originality/valueThe results of this study provide a new understanding of auditor responses to institutional investor monitoring and political connections (PCs) in an emerging economy.
Unmasking the dark triad: exploring its relationship with attitudes toward intimate partner violence
Authors: Waite Charlie , Mooney Robyn 
Published: June 2024

Purpose
Although it is a relatively recent conceptualization of malevolent personality, the dark triad (DT) has been widely researched and shown to be responsible for increases in physical violence, controlling behavior, short-term mating preferences and poor relationship quality. This study aims to investigate whether DT traits predict acceptance toward intimate partner violence (IPV) in the general population, addressing a gap in the literature regarding predictors of harmful attitudes toward romantic relationships.

Design/methodology/approach
In total, 150 adults aged 18–74 (76% women) completed two self-report questionnaires: the short DT and the IPV attitude scale-revised.

Findings
A series of hierarchical multiple regression analyses were conducted, with gender as predictor in the first models and DT traits added as predictors in second models. The results showed that male participants were more accepting of IPV than female participants. Over and above the contribution of gender, psychopathy and Machiavellianism positively predicted overall IPV acceptance, but narcissism did not. Psychopathy and Machiavellianism positively predicted acceptance of psychological abuse, and psychopathy positively predicted acceptance of controlling behaviors. Narcissism did not predict any facet of IPV acceptance.

Originality/value
To the best of the authors’ knowledge, as the first study to explore the roles of DT traits in acceptance of IPV behaviors, the results contribute to the understanding of how these traits may predispose individuals to harmful intimate partner behaviors. These findings can inform IPV prevention efforts to aid in the early identification of individuals who hold maladaptive beliefs surrounding romantic relationships.
Mapping the landscape of digital cultural heritage research: a quantitative and visual bibliometric study
Authors: Huang Yong , He Xiangfeng , Lian Zhiguang , Yang Zhirong 
Published: June 2024

PurposeThis study explores the deep integration of digital technology and cultural heritage to promote the preservation and inheritance of cultural heritage. Focusing on Digital Cultural Heritage (DCH), this research investigates its key role in activating theoretical research and practical applications in cultural heritage.Design/methodology/approachThis study conducted an extensive bibliometric analysis utilizing VOSviewer and Bibliometrix visualization software to meticulously examine DCH research. Insights were gleaned from a dataset comprising 2,997 DCH-related publications harvested from the Web of Science database.FindingsThe bibliometric analysis reveals several notable findings: driven by active contributions from Italy, China, Spain, and the USA, the number of DCH publications shows a linear upward trend. Consiglio Nazionale delle Ricerche in Italy emerges as a prominent institution, while the Journal of Cultural Heritage stands out as the most influential journal in the DCH field. Scholars such as Remondino, Guidi, Barazzetti, and Carrozzino have significantly impacted DCH research. Furthermore, an in-depth analysis of keyword co-occurrence networks elucidates six major research trajectories in the DCH field, covering various aspects from cultural heritage digitization to digital humanities.Practical implicationsThe study emphasizes the value of global knowledge exchange, interdisciplinary collaboration, innovative technology applications, and digital content provision practices in advancing DCH research.Originality/valueBy delving into the multifaceted landscape of DCH research, this study brings forth original insights into the escalating trends, pivotal contributors, and burgeoning research directions.
Herbarium and field studies of nickel hyperaccumulator plants from ultramafic soils in Guatemala
Authors: Disinger Haley P. , Navarrete Gutiérrez Dulce Montserrat , Díaz Reyes Alicia Maríasol , Rodas Duarte Rosario , Quezada Maura L. , van der Ent Antony , Baker Alan J. M. , Echevarria Guillaume , Pollard A. Joseph 
Published: June 2024

AbstractUntil 2019, there were no published reports of trace element hyperaccumulation in the plants of Central America or Mexico. Recent reports, based mostly on measurement of herbarium specimens using x‐ray fluorescence (XRF) spectroscopy, have begun to identify hyperaccumulators of nickel (Ni) in this region. The most extensive deposits of Ni‐rich ultramafic rocks and soils in Central America occur along the Polochic‐Motagua fault system in eastern Guatemala. This study focused on discovery and characterization of new hyperaccumulators in Guatemala, starting with surveys of herbarium specimens, followed by field studies to understand the ultramafic soils of the region and the ecology of hyperaccumulators that occur there. Initial XRF screening at the Missouri Botanical Garden Herbarium, along with two herbaria in Guatemala, identified four previously unreported Ni hyperaccumulators—Arachnothryx linguiformis, Arachnothryx buddleioides, Chionanthus panamensis, and Orthion guatemalense. Field studies in Guatemala characterized the communities in which these species occur, some of which include multiple hyperaccumulator species growing in close proximity. In two taxa that showed phenotypic variation in foliar Ni concentration, there was no statistically significant correlation between Ni concentrations in leaves and either the total or DTPA‐extractable Ni in soils, suggesting that other genetic or environmental variables may influence hyperaccumulation.
Meat production and zoonotic disease outbreaks in Asia
Authors: Koren Ore , Steinberg Jessica , Hagar Amit 
Published: June 2024

AbstractIs there a link between meat production and infectious diseases? Researchers, policymakers and pundits argue that the growth of demand for meat in Asia can increase the risk of zoonotic diseases, pathogens that originate in animals and can be transmitted to humans. Using original data on zoonotic disease outbreaks in 22 Asian countries between 1996 and 2019, this study examines the impact of beef, chicken and pork production on zoonotic outbreaks—focussing on all diseases and disaggregated subcategories. Because such outbreaks lead to culling animals, data on inorganic chemical fertiliser use are used to identify the plausibly exogenous relationship flowing from meat production to outbreaks. Results indicate that in these countries, intensive meat production may have contributed to a 16%–300% rise (for a one‐million‐tonne increase in output) in zoonotic outbreak incidence. Findings also suggest this relationship is primarily driven by flu pathogens' higher sensitivity to meat production, with a one‐million‐tonne increase in output being associated with a 48%–530% rise in the number of predicted flu outbreaks. These results are consistent across numerous sensitivity analyses accounting for modelling, operationalisation, and data selection choices.
Scandalisation, gender and space in ancient Rome: The case of Cicero and Clodia
Authors: Moser Muriel 
Published: June 2024

AbstractThis article analyses the public attack on Clodia Metelli, a Roman aristocratic woman, by the orator Marcus Tullius Cicero in a trial in 56 BCE. Drawing on modern scandal theory, this article analyses how Cicero uses scandal dynamics to turn Clodia, the witness in the case, into the culprit. The article discusses, first, the dynamics of his scandalisation of Clodia and the importance of Roman gender norms and their spatial expressions in his attack and, second, Cicero's role as scandaliser and norm‐setter.
A review of the contributions of forensic archaeology and anthropology to the process of disaster victim identification
Authors: Hanson Ian , Fenn James 
Published: June 2024

AbstractForensic archaeology and anthropology have developed significantly over past decades and now provide considerable assistance to the investigation process of disaster victim recovery and identification. In what are often chaotic death and crime scenes, the formal process of utilizing archaeological methods can bring control, order, and ensure systematic search. Procedures assist in defining scene extent, locating victims and evidence, rule out areas for consideration, and provide standardized recording and quality assurance through dedicated use of standardized forms (pro formas). Combined archaeological and anthropological search methods maximize opportunities to recovery the missing through identifying remains, mapping distributions, and providing accounting of victims at the scene. Anthropological assistance in examinations contributes to individual assessment, resolving commingling and fragmentation issues, and utilizing DNA sampling methods and matching data to reassociate and account for the missing. Utilization of archaeology, anthropology, and DNA matching data provides scope to review crime scene recovery and determine requirements and potential for further survey and retrieval. Adopting the most suitable methods for a particular context can maximize recovery, efficiency, and resource use. Case studies demonstrate the utility of archaeological methods in a range of scenarios. They exemplify the success of multidisciplinary analysis in providing evidence of the sequence of events, the timing of events, the impact of taphonomic processes, the location and accounting of victims, and the demonstration of systematic scene search. The considerations provided in this article, utilizing archaeology and anthropology processes, may assist investigators in planning and implementing responses to mass fatalities.
Pain in people seeking and receiving opioid agonist treatment: A systematic review and meta‐analysis of prevalence and correlates
Authors: Yang Jie , Jung Monica , Picco Louisa , Grist Elizabeth , Lloyd‐Jones Martyn , Giummarra Melita , Nielsen Suzanne 
Published: June 2024

AbstractBackground and AimsPeople with opioid use disorder (OUD) commonly experience pain including chronic pain. Despite the high prevalence, few studies have systematically examined the prevalence and correlates of pain among people seeking or receiving opioid agonist treatment (OAT) for OUD. This review aimed to determine the prevalence of pain in this population globally, and estimate the association between chronic pain and other demographic and clinical characteristics.MethodsElectronic searches were conducted in three databases (Medline, Embase and PsycINFO) from the inception until October 2022. Eligible studies reported prevalence rates of current and/or chronic pain. Meta‐analyses examining the main prevalence estimates were conducted by Stata SE 18.0, and comorbid clinical conditions were analysed by Review Manager 5.4.ResultsFifty‐six studies (n participants = 35 267) from sixty‐seven publications were included. Prevalence estimates of current and chronic pain were reported in 27 (48.2%) and 40 studies (71.4%), respectively. Most studies were conducted in North America (71.4%, n = 40) and used cross‐sectional designs (64.3%, n = 36). Meta‐analyses revealed a pooled prevalence of 60.0% (95% confidence interval [CI]: 52.0–68.0) for current pain and 44.0% [95% CI: 40.0–49.0] for chronic pain. Chronic pain was positively associated with older age (mean deviation of mean age: 2.39 years, 95% CI: 1.40–3.37; I2 = 43%), unemployment (odds ratio [OR] = 0.57, 95% CI: 0.42–0.76; I2 = 78%), more severe mental health symptoms (e.g. more severe depression (standardised mean difference [SMD] of mean scores: 0.45, 95% CI: 0.20–0.70; I2 = 48%) and anxiety symptoms (SMD: 0.52, 95% CI: 0.17–0.88; I2 = 67%), and hepatitis C (OR = 1.41, 95% CI: 1.03–1.94; I2 = 0%). No association was observed between chronic pain and the onset and type of OAT, geographic location, study design, survey year, participant age or use of specific pain assessment tools.ConclusionsThere appears to be a high prevalence of pain among people seeking or receiving opioid agonist treatment for opioid use disorder compared with the general population, with positive associations for older age, unemployment, hepatitis C and the severity of some mental health symptoms.
Holter study of heart rate variability in children and adolescents with long QT syndrome
Authors: Lundström Anna , Eliasson Håkan , Karlsson Marcus , Wiklund Urban , Rydberg Annika 
Published: June 2024

AbstractObjectivesThis study aimed to retrospectively assess cardiac autonomic activity in children with LQTS, considering genotype, symptoms, sex, age, and beta‐blocker therapy (BB) and compare it to healthy controls.MethodsHeart rate variability (HRV), using power spectrum analysis, was analyzed in 575 Holter recordings from 116 children with LQTS and in 69 healthy children. The data were categorized into four age‐groups and four heart rate (HR) ranges.ResultsIn LQT1 and LQT2, increasing HR corresponded to significantly lower low (LF) and high frequency (HF) compared to controls. Total power (PTOT) was lower in all LQT1 age‐groups compared to controls at HR 120–140 bpm (1–15 years: p < .01; 15–18 years: p = .03). At HR 80–100, LQT1 patients aged 1–10 years had lower HF than LQT2 patients (1–5 years: p = .05; 5–10 years: p = .02), and LQT2 patients aged 15–18 years had lower HF than LQT1 patients (p < .01). Symptomatic patients aged 10–15 years had lower PTOT at HR 100–120 bpm than asymptomatic patients (p = .04). LQT1 girls aged 10–15 and 15–18 years had a lower PTOT (10–15 years: p = .04; 15–18 years: p = .02) than boys.ConclusionThis study shows a correlation between HR and changes in HRV parameters. At higher HRs, LQTS patients generally had lower HRV values than controls, suggesting an abnormal autonomic response. These results may strengthen the link between physical activity and arrhythmias in LQTS.
Effectiveness of chatbots in increasing uptake, intention, and attitudes related to any type of vaccination: A systematic review and meta‐analysis
Authors: Chan Paul Shing‐fong , Fang Yuan , Cheung Doug H. , Zhang Qingpeng , Sun Fenghua , Mo Phoenix K. H. , Wang Zixin 
Published: June 2024

AbstractThis systematic review and meta‐analysis analyzed and summarized the growing literature on the effectiveness of chatbot‐delivered interventions in increasing uptake, intention, and attitudes related to any type of vaccination. We identified randomized controlled studies (RCTs), quasi‐experimental studies, and non‐experimental studies from the following platforms: PubMed, Web of Science, MEDLINE, Global Health, APA PsycInfo, and EMBASE databases. A total of 12 eligible studies published from 2019 to 2023 were analyzed and summarized. In particular, one RCT showed that a chatbot‐delivered tailored intervention was more effective than a chatbot‐delivered non‐tailored intervention in promoting seasonal influenza vaccine uptake among older adults (50.5% versus 35.3%, p = 0.002). Six RCTs were included in the meta‐analysis to evaluate the effectiveness of chatbot interventions to improve vaccination attitudes and intentions. The pooled standard mean difference (SMD) of overall attitude change was 0.34 (95% confidence intervals [CI]: 0.13, 0.55, p = 0.001). We found a non‐significant trivial effect of chatbot interventions on improving intentions of vaccination (SMD: 0.11, 95% CI: −0.13, 0.34, p = 0.38). However, further evidence is needed to draw a more precise conclusion. Additionally, study participants reported high satisfaction levels of using the chatbot and were likely to recommend it to others. The development of chatbots is still nascent and rooms for improvement exist.
Perceived organizational justice in family SMEs: The challenge of HRM consistency
Authors: Kroon Brigitte , Kramer Astrid , Kox Joyce 
Published: June 2024

AbstractLiabilities of smallness, family relations, leadership style, and preferences are all reasons why owners of small and medium‐sized family enterprises (family SMEs) apply procedures to manage employees inconsistently. For family and non‐family employees of family SMEs, inconsistencies in human resource management (HRM) may be a source of frustration that hampers their performance and wellbeing. Using a sample of 713 respondents in 116 family SMEs, we examined how HRM consistency as a whole, and as three HRM bundles (ability, motivation, and opportunity) could enhance the perceived organizational justice of employees in family SMEs, and whether this differs for family and non‐family employees. We indeed found that HRM consistency is a condition for perceived organizational justice of employees and that this effect was more pronounced for non‐family employees than for family employees. We explain this difference by the distinct environment where the fairness heuristics of employees developed. Where non‐family employees develop their fairness heuristics only in the business sphere, family employees start to develop their fairness heuristics earlier on in the family sphere. We also found evidence that inconsistencies in the motivation‐enhancing HRM bundle were most susceptible to negative perceptions of organizational justice.