bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEASONAL VARIATIONS IN FATTY ACID COMPOSITION OF OIL IN DEVELOPING COCONUT
Authors: NARESH KUMAR S. , BALAKRISHNA A. 
Published: April 2009

ABSTRACT Studies on seasonal variation in oil and fatty acid profile of developing solid endosperm of two cultivars, West Coast Tall (WCT) and Chowghat Orange Dwarf (COD), and their hybrids indicated that oil percentage increased from 30% in 6‐month‐old nuts to 63% in matured nuts (12 months old). Nuts sampled during July from different levels of maturity had high oil percentage and followed by those sampled during April, October and January. During nut development to maturity, the percentages and contents of medium and long chain saturated fatty acids increased except that of palmitic and myristic acids. Concentration of long chain unsaturated fatty acids (LCUFAs) in developing coconut kernel were high at 5 and 6 months after fertilization and then decreased toward maturity. The LCUFAs were high in nuts developing during October; consequently, saturated to unsaturated fatty acid ratios were low during October. Results indicated that nuts matured during October had better nutritional quality for human consumption and those matured during January are more suitable for industrial purpose due to higher medium chain fatty acid concentrations. PRACTICAL APPLICATIONSCoconut is consumed either as the tender nut (5–6 months after fertilization) or as the kernel from mature nut (12 months after fertilization). Recent technologies of making snowball tender nut use the nuts aged 7–8 months old. Kernel also is consumed in this product. Apart from this, the coconut is being increasingly used for making different kernel‐based value‐added products. This information is useful, as the value‐added products are being developed using different maturities of coconut. Hence, it is of paramount importance that the fatty acid profile of coconut kernel is known in detail for assessing the safety of food consumption from the human health point of view. Apart from this, information on the seasonal variation in fatty acid profile of developing endosperm gives an integrated knowledge so as to optimize the usage of coconut kernel for both human consumption and industrial exploitation.
Depression, quality of life, and glycemic control in individuals with type 2 diabetes
Authors: Lee Hyeon‐Joo , Chapa Deborah , Kao Chi‐Wen , Jones Deborah , Kapustin Jane , Smith Jamie , Krichten Cathy , Donner Thomas , Thomas Sue A. , Friedmann Erika 
Published: April 2009

AbstractPurpose: The purpose of this article is to evaluate the contributions of diabetic complications to depression beyond the contributions of demographic characteristics in patients with type 2 diabetes. Further, this article evaluates the contributions of diabetic complications, depression, and quality of life to A1C (also know as HbA1c) beyond the contributions of demographic characteristics in individuals with type 2 diabetes.Data sources: A cross‐sectional survey of 55 individuals with type 2 diabetes attending an inner city diabetes specialty clinic. Patients completed the Beck Depression Inventory – II, the Inventory of Depressive Symptomatology Self‐Report, the Medical Outcome Study Short Form‐36, and a demographic questionnaire. A1C and diabetes‐related comorbidities were obtained from the patients’ medical records.Conclusions: Being younger and female were associated with depression in individuals with type 2 diabetes. After controlling for age and gender, neuropathy tended to add to the prediction of depression; other comorbidities did not. Being black was associated with poor diabetic control (A1C > 7). After controlling for race, neuropathy and retinopathy predicted poor diabetes control and depression tended to predict poor diabetes control.Implications for practice: Given the high prevalence of depression, the relationship of depression with poor diabetic self‐care and medication adherence, and the increased cost of treatment for patients with depression among individuals with type 2 diabetes, assessment of depression is crucial. Further research is needed to establish effective treatment of depression and its effect on glycemic control in patients with type 2 diabetes.
Structures and Properties of Nonchelated, d0 Alkyl Alkene Complexes of the Type [Cp2ZrMe(alkene)]+: Elusive Intermediates during Ziegler–Natta Polymerizations of Alkenes
Authors: Sauriol Francoise , Wong Elizabeth , Leung Angela M. H. , Donaghue Irja Elliott , Baird Michael C. , Wondimagegn Tebikie , Ziegler Tom 
Published: April 2009

AbstractAuf frischer Tat ertappt: Der abgebildete Alkyl(alken)zirconium(IV)‐Komplex (Cp=C5H5) wurde synthetisiert und charakterisiert. Das Alken ist sehr unsymmetrisch gebunden, sodass C2 einen stark carbokationischen Charakter hat. Ferner war eine Rotation um die C1‐C2‐Bindung nachweisbar. Dieser außergewöhnliche Komplex kann als Modell für bislang unbekannte Zwischenstufen in Ziegler‐Natta‐ und carbokationischer Alkenpolymerisation angesehen werden.magnified image
Fluorescence Quenching of Pheophytin‐a by Copper(II) Ions
Authors: HU Mingbo , LI Huaixiang , CHEN Lusheng , ZHANG Huaibin , DONG Chuan 
Published: April 2009

Abstract A method was developed for determination of Cu(II) ions quantitatively by measuring fluorescent intensity of pheophytin‐a (Pheoa) solution. The Pheoa was obtained by de‐intercalation of magnesium from the porphyrin ring of chlorophyll‐a (Chla) extracted from fresh spinach leaves. Its two UV‐Vis absorption peaks at 505 and 535 nm in acetone solution have been observed but disappeared when the acetone solution of Pheoa was mixed with a Cu(II) ion aqueous solution. A fluorescence quenching phenomenon was thus observed when the acetone solution of Pheoa was mixed with an aqueous solution of Cu(II) ions. However, other physiologically relevant cations rarely caused any quenching fluorescence of Pheoa under the same experimental conditions. Kinetics of the fluorescence fading process was investigated by measuring the effects of Cu(II) ion concentration, reaction time and reaction temperature on the fluorescence intensity of the Pheoa acetone solution. An activation energy of (10±1) kJ·mol−1 was estimated from Arrhenius empirical relation assuming that the interaction between the Pheoa and the Cu(II) ions was the first order reaction. The calibration graph obtained with the fluorescence was linear over the Cu(II) concentration range of 8.0×10−5−8.0×10−7 mol·dm−3 with a detection limit of 8.0×10−7 mol·dm−3 for Cu(II) ion.
Morphometric characterization of murine articular cartilage—Novel application of confocal laser scanning microscopy
Authors: Stok Kathryn S. , Müller Ralph 
Published: April 2009

AbstractA new technique for characterization of the three‐dimensional morphology of murine articular cartilage is proposed. The technique consists of a novel application of confocal laser scanning microscopy (CLSM), where the objective was to develop and validate it for cartilage measurements in murine joints. Murine models are used in arthritis research, because they are well‐described for manipulating the disease pathophysiology, facilitating our understanding of the disease, and identifying new targets for therapy. A calibration and reproducibility study was carried out to provide a consistent testing methodology for quantification of murine joints. The proximal tibial condyles from male C57BL/6 mice were scanned using a CLS microscope with an isotropic voxel size of 5.8 μm. Measurements and analyses were repeated three times on different days, and in a second step the analysis was repeated three times for a single measurement. Calculation of precision errors (coefficient of variation) for cartilage thickness and volume was made. The bias of the system was estimated through comparison with histology. This technique showed good precision, with errors in the repeated analysis ranging from 0.63% (lateral thickness) to 3.48% (medial volume). The repeated analysis alone was robust, with intraclass correlations for the different compartments between 0.918 and 0.991. Measurement bias was corrected by scaling the confocal images to 32% of their width to match histology. CLSM provided a fast and reproducible technique for gathering 3D image data of murine cartilage and will be a valuable tool in understanding the efficacy of arthritis treatments in murine models. Microsc. Res. Tech. 2009. © 2009 Wiley‐Liss, Inc.
Conformations of monoacyl and 1,3‐diacylbenzimidazoline‐2‐thiones and dihydrobenzimidazoles
Authors: Ibrahim Mustafa R. , Jarrar Adil A. , Sabri Salim S. 
Published: April 2009

AbstractThe endo confrontation of monoacyl and 1,3‐diacylbenzimidazoline‐2‐thiones is predominant at ambient temperatures. Nmr temperature‐dependent studies suggest that this is also true over a wide range of temperatures. In agreement with previous results (6) the exo‐endo conformation in 1,3‐diacyl‐1,2‐dihydrobenzimidazoles is generally the predominant one.
Studies on indenopyridine derivatives and related compounds. II. Stereochemistry of 1‐substituted 9‐phenyl‐1,3,4,4a,9,9a‐hexahydro‐4‐hydroxy‐2H‐indeno[2,1‐b] pyridines and their acetates
Authors: Kurihara Takushi , Hirano Hiroshi 
Published: April 2009

AbstractChemical and catalytical reduction of 1‐methyl‐ or 1‐benzyl‐phenyl‐1,3,4,9‐tetrahydro‐2H‐indeno[2,1‐b ]pyridin‐4‐ones (VIIa,b) afforded 1‐methyl‐ or 1‐benzyl‐9‐phenyl‐1,3,4,4a,9,9a‐ hexahydro‐4‐hydroxy‐2H‐indeno[2,1‐b ]pyridines (IXa,b), which gave the corresponding acetates (Xa,b) by treatment with acetic anhydride and pyridine. Based upon a detailed study of 100 MHz nmr spectra of these compounds, it was concluded that the hydroxy group of IXa,b has an axial configuration taking B/C cis stable form which has the large aromatic group equatorial with respect to the piperidine ring, whereas the acetoxy group of Xa,b is equatorial taking an unfavorable B/C cis unstable form which has the large aromatic group axial with respect to the piperidine ring.
Pyridazines. LXX. Reactions of azidoazolopyridazines with unsaturated compounds
Authors: Jurgec M. , Kovačič M. , Stanovnik B. , Tišler M. , Volk M. 
Published: April 2009

AbstractCycloaddition reactions of azidoazolopyridazines with unsaturated esters, cyclic enol ethers, styrene, 2‐vinyl‐pyridine, bicyclo[2.2.1]heptene, dicyclopentadiene and dehydrobenzene were investigated. The reaction proceed via the intermediate Δ2 ‐1,2,3‐triazolines which were in most cases termolabile and decomposed further to give the final products which were enamines, imines of fused aziridines.
Synthesis of insect trail pheromones: The isomeric 3‐butyl‐5‐methyloctahydroindolizines
Authors: Sonnet Philip E. , Oliver James E. 
Published: April 2009

AbstractThe syntheses of the geometrical isomers of 3‐butyl‐5‐methyloctahydroindolizine are described. These compounds, reported as trail pheromones of Pharaoh ants, Monomorium pharaonis (L.), cannot be distinguished from each other by physical data alone and assignments must therefore be based on unambiguous synthesis. Routes to these compounds via suitably constituted dialkylpiperidines and a sequence involving a dialkylpyrrole are described. Infrared and nmr spectral data are presented. These data are examined for their potential in conformaational analyses of these compounds.
1,2,4‐Triazino[4,3‐c]‐ and [2,3‐c]quinazolines. II
Authors: Trepanier Donald L. , Sunder Shyam 
Published: April 2009

AbstractThis paper describes the results of allowing a variety of reagents, such as, aldehydes, ketones, carboxylic acids, acid chlorides, ortho esters, isocyanates, S‐methylisothiourea, carbon disulfide, phosgene, nitrous acid, and cyanogen bromide to react with the multifunctional compound, 3‐(o‐aminophenyl)‐1‐methyl‐1,4,5,6‐tetrahydro‐1,2,4‐triazine.
Furannes et pyrroles disubstitués en 2,3. XVI synthèse de furo[3,2‐c]pyranones‐4 et nouvelle voie d'accès aux furo[3,2‐c]pyridines
Authors: Bisagni Emile , Civier Alain , Marquet Jean‐Pierre 
Published: April 2009

AbstractLa condensation du chloracétaldéhyde sur l'hydroxy‐4 méthyl‐6 pyranone‐2 engendre la méthyl‐6 furo[3,2‐c]pyranone‐4. Celle‐ci réagit avec l'ammoniaque et certaines amines pour donner les furo[3,2‐c]pyridones‐4 N‐substituées correspondantes qui se forment egalement à partir des hydroxy‐4 α‐pyridones.Par ailleurs, la furo[3,2‐c]pyranone‐4 est acylée sur son sommet 2 et la chloro‐4 méthyl‐6 furo[3,2‐c]pyridine donne aisément divers dérivés de substitution par déplacement de son halogène.
Synthesis of pyrido[1,2‐a]pyrimido[4,5‐d]pyrimidin‐5‐ones. Cyclization reaction of 4‐[(3‐hydroxy‐2‐pyridyl)amino]‐2‐phenyl‐5‐pyrimidinecarboxylic acid with acetic anhydride
Authors: Kim Dong Han , Santilli Arthur A. 
Published: April 2009

AbstractTreatment of 4‐[(3‐hydroxy‐2‐pyridyl)amino]‐2‐phenyl‐5‐pyrimidinecarboxylic acid (X) with acetic anhydride under refluxing conditions afforded 10‐hydroxy‐2‐phenyl‐5H‐pyrido[1,2‐a]‐pyrimido[4,5‐d]pyrimidin‐5‐one acetate (IX). The intermediate X was prepared from 4‐chloro‐2‐phenyl‐5‐pyrimidinecarboxylic acid ethyl ester (V). The reaction of V with the sodium salt of 2‐amino‐3‐hydroxypyridine at room temperature gave 4‐(2‐amino‐3‐pyridyloxy)‐2‐phenyl‐5‐pyrimidinecarboxylic acid ethyl ester (VI). Treatment of VI with a hot aqueous sodium hydroxide solution and subsequent acidification gave X. Involvement of 4‐[(3‐hydroxy‐2‐pyridyl)amino]‐2‐phenyl‐5‐pyrimidinecaroboxylic acid ethyl ester (VIII) (Smiles rearrangement product) as an intermediate in the above alkaline hydrolysis reaction of VI to X was demonstrated by the isolation of VIII and its subsequent conversion into X under alkaline hydrolysis conditions. Acetylation of VIII with acetic anhydride in pyridine solution gave 4‐[(3‐hydroxy‐2‐pyridyl)amino]‐2‐phenyl‐5‐pyrimidinecarboxylic acid ethyl ester acetate (XI), which afforded IX on fusion at 220°. This alternative synthesis of IX from XI supported the structural assignment of IX. Fusion of VI gave 10‐hydroxy‐2‐phenyl‐5H‐pyrido[1,2‐a]pyrimido]4,5‐d]pyrimidin‐5‐one (VII). The latter was also obtained when VIII was fused at 210°. Acetylation of VII with acetic anhydride afforded IX.
Novel polycyclic heterocycles. XIV. 1,2‐Dihydro‐4‐(trifluoromethyl)‐3H‐8H‐quino[1,8‐ab][4,1]benzoxazepin‐3‐one and its derivatives
Authors: Yale Harry L. , Bristol James A. , Petigara Ramesh B. 
Published: April 2009

AbstractProcedures for the isolation of 1,2‐dihydro‐4‐(trifluoromethyl)‐3H,8H‐quino[1,8‐ab][4,1]‐benzoxazepine, 3, from reaction mixtures containing 3 as the minor component, and the isomer, 1,2‐dihydro‐11‐(trifluoromethyl)‐3H,7H‐quino[8,1‐cd][1,5]benzoxazepin‐3‐one, 2, as the major component, are described. The reactivity of 3 toward hydroxylamine and aromatic aldehydes has been investigated and the preparation of derivatives with those reactants is described.
A convenient one‐step synthesis of 6‐selenoxo‐9‐(β‐D‐ribofuranosyl)purine 3′,5′‐cyclic phosphate and related compounds
Authors: Shiue Chyng‐Yann , Chu Shih‐Hsi 
Published: April 2009

AbstractA useful, facile procedure for preparing seleno‐heterocyclic compounds is reported. Treatment of cAMP, AMP, adenosine, 2‐aminoadenosine, adenine arabinoside and formycin with hydrogen selenide in aqueous pyridine at 65° for 1.5‐5 days gave the corresponding seleno compounds in good yield, while these compounds were relatively inert to hydrogen sulfide. A reaction mechanism is proposed.
The cyclocondensation of 5‐amino‐1,3‐dimethylpyrazole with ethyl acetoacetate. Synthesis of isomeric pyrazolopyridones
Authors: Ratajczyk James D. , Swett Leo R. 
Published: April 2009

AbstractThe reaction of 5‐amino‐1,3‐dimethylpyrazole with ethyl acetoacetate yielded two isomeric pyrazolopyridones which were identified as their corresponding tetrahydropyrazolopyridine derivatives and by their ir, pmr and 13C‐nmr spectral data. Additional proof was provided by a separate synthetic route involving the Friedländer reaction.
Transformations in the pyridine series. An improved preparation of 3‐methyl‐4‐phenylpyridine
Authors: Inoue Hirozumi , Thyagarajan G. , May Everette L. 
Published: April 2009

AbstractAn improved, large‐scale preparation of 3‐methyl‐4‐phenylpyridine (V) is described. This compound was converted to 3‐methyl‐4‐phenylpicolinic acid (VII) which could not be reduced to the desired piperidine congener (IV).
Electron‐impact induced rearrangements in isomeric pyridine aldoximes
Authors: Zaretskii Ze'ev V. I. , Ben‐Bassat Albert Avraham , Lavie David 
Published: April 2009

AbstractThe mass spectra of α‐, β‐ and γ‐pyridine aldoximes and the respective O‐methyl ethers were studied. The mass spectral behaviour of α‐pyridine aldoxime is characterized by the elimination of NO, while the molecular ion of the γ‐isomer expels H2 CN. In the case of the β‐isomer the formation of the m/e 67 ion (C4H5N) in a concerted process is the main feature. In the α‐pyridine aldoxime methyl ether, in sharp contrast to the hydroxy analog, the M‐30 peak was found to be due to the elimination of CH2O, the expulsion of NO being absent. The mechanism of the fragmentation reactions is discussed, the conclusion drawn being based on the high resolution measurements as well as on the spectra of the respective deuterioanalogs and on the metastable transitions.
Reactivity of 2‐amino‐1,3,4‐thiadiazoles. Methylation reactions of some 2‐amino‐5‐benzoyl‐1,3,4‐thiadiazoles
Authors: Werber Giuseppe , Buccheri Francesco , Vivona Nicolò 
Published: April 2009

AbstractMethylation reactions of 2‐amino‐5‐benzoyl‐1,3,4‐thiadiazoles 1a‐d are reported as a function of alkylating agents (methyl iodide, dimethyl sulfate‐potassium carbonate, diazomethane, dimethyl‐sulfate‐sodium methoxide). Methylation occurs at both the ring nitrogen in position 3 and the exocyclic nitrogen atom.
Reactivity of 2‐fluoro‐5‐nitrothiophene towards sodium thiophenoxide and piperidine. Comparison with other 2‐halogeno‐5‐nitrothiophenes
Authors: Guanti Giuseppe , Thea Sergio , Dell'Erba Carlo , Leandri Giuseppe 
Published: April 2009

Abstract2‐Fluoro‐5‐nitrothiophene reacts with sodium thiophenoxide and piperidine much faster than other 2‐halogeno‐5‐nitrothiophenes. In methanol the reactions with both nucleophiles follow overall second order kinetics, while in benzene the observed second order rate constants of the reaction with piperidine show a linear dependence by the piperidine concentration. Such a dependence, which is mild for the chloro, bromo and iodo derivative, becomes strong for the fluoro compound. Moreover, the reaction of 2‐fluoro‐5‐nitrothiophene with [1‐2H]piperidine shows the absence of a primary isotope effect. The results are interpreted within the framework of the two‐stage, intermediate‐complex mechanism, the first stage (attack of the nucleophile on the substrate) being rate determing for the reactions of 2‐fluoro‐, ‐chloro‐, ‐bromo‐ and ‐iodo‐5‐nitrothiophene with thiophenoxide in methanol and of 2‐chloro‐, ‐bromo‐ and ‐iodo‐5‐nitrothiophene with piperidine in benzene. In the case of the reaction of 2‐fluoro‐5‐nitrothiophene with piperidine in benzene the data are in agreement with a mechanism in which the rate determining step is the decomposition of the tetrahedral intermediate into products. The intervention of a second amine molecule in the transition state of the rate determining step can be rationalized in terms of bifunctional catalysis. A comparison of reactivity of thiophenoxide and piperidine towards 2‐halogeno‐5‐nitrothiophenes (Hal = F, Cl, Br, I) indicates a greater sensitivity of the reaction with piperidine than that with thiophenoxide to the change of the leaving group.
Synthesis of [1]benzopyrano[3,4‐b] [1,4]oxazines as potential antidepressants
Authors: Julian David R. , Matusiak Zbigniew S. 
Published: April 2009

AbstractStereospecific syntheses, from Δ‐3‐chromene, of cis and trans‐4‐aminochroman‐3‐ols, 5 and 8, and their conversion into cis and trans‐1,2,3,4a,5,10b‐hexahydro[1]benzopyrano[3,4‐b][1,4]‐oxazines, 15 and 16, are described.
Synthesis of carbostyril derivatives by reaction of aldehydes with oxazolines
Authors: Wehrmeister H. L. 
Published: April 2009

AbstractCarbostyril derivatives are obtained on reaction of o‐chlorobenzaldehyde and derivatives with 2‐alkyl‐4,4‐dimelhyl‐2‐oxazolines with elimination of methallyl chloride. Phenylethenyloxazolines are presumed intermediates.
Spectral properties of mono‐and dihydroxychromones
Authors: Romussi G. , Ciarallo G. 
Published: April 2009

AbstractThe uv, ir, and nmr spectra of a number of hydroxy‐and methoxychromones, substituted only in the benzene ring, were studied. The results are particularly useful in determining the position of the hydroxyl groups. Chromatographic data on paper are also given.
Photoalkylation of phenanthro[9,10‐d] oxazole
Authors: Maeda M. , Iwase Y. , Kojima M. 
Published: April 2009

AbstractThe photochemical reaction of phenanthro[9,10‐d]oxazole with ethanol, 1‐propanol, 2‐propanol, or diethyl ether resulted in the substitution of the 1‐and/or 2‐hydroxyalkyl and/or alkyl groups at the position 2.
Nouvelle voie d'accès aux 1H‐dihydro‐2,3 pyridones‐4
Authors: Eskenazi Christian , Lhommet GÉRard , Richaud Marie‐GeneviÈVe , Maitte Pierre 
Published: April 2009

Abstractl'action de l'ammoniac et des amines primaires permet de transformer les dihydro‐2,3 pyrones‐4 en pyridones correspondantes, mais cette méthode n'est pas applicable aux éthoxycarbonyl‐5 dihydro‐2,3 pyrones‐4.
Epimerization and deuterium exchange studies in selected cis,trans‐1‐alkyl‐2‐aryl(alkyl)‐3‐aroylaziridines
Authors: Tarburton Philip , Chung A. , Badger Robert C. , Cromwell Norman H. 
Published: April 2009

AbstractA series of base catalyzed reactions performed on selected cis, trans‐1‐alkyl‐2‐aryl(alkyl)‐3‐aroylaziridines at room temperature reveal the cis isomer to be of greater thermodynamic stability. Furthermore, base catalyzed deuterium exchange studies suggest this to be the case. Solvent effects on the isomeric cis/trans ratios are also presented and discussed.
Tetrahydropyridinediols and related aldehydes from the reactions of pyridine N‐oxide with mercaptans
Authors: Kokosa John M. , Bauer Ludwig , Egan Richard S. 
Published: April 2009

AbstractA new series of tetrahydropyridines was isolated when 1‐adamantyl or t‐butyl mercaptan was added last to a solution of pyridine N‐oxide and triethylamine in acetic anhydride. Under these conditions, the predominant tetrahydropyridines proved to be 1‐acetyl‐2‐alkylthio‐3‐acetoxy‐6‐hydroxy‐1,2,3,6‐tetrahydropyridines. These carbinolamides were isomerized in part during silica gel column chromatography to trans‐4‐acetoxy‐5‐alkylthio‐5‐acetamido‐2‐pentenals.
Synthesis and epimerization of 1‐Alkyl‐2‐carbomethoxy‐4‐methyl (or phenyl)azetidines
Authors: Kulkarni Shrikant B. , Rodebaugh Richard M. , Cromwell Norman H. 
Published: April 2009

AbstractA number of 1‐alkyl‐2‐carbomethoxyazetidines have been prepared from the reaction of primary amines with α,γ‐dibromoearbonyl compounds. A series of base catalyzed reactions performed on selected cis, trans‐1‐alkyl‐2‐carbomethoxy‐4‐alkyl(aryl)azetidines reveal the cis isomer to be of greater thermodynamic stability. Furthermore, base catalyzed deuterium exchange studies suggest this to be the case.
Nuclear bishydroxylation with peroxydisulfate
Authors: Rao Koppaka V. , Owoyale Jacob A. 
Published: April 2009

AbstractOxidation of 3,3′,4′,7‐tetra‐O‐methylquercelin by alkaline peroxydisulfate gave, in addition to the known 5,8‐dihydroxy derivative, a comparable yield of the 5,6,8‐trihydroxy compound. It was characterized by complete methylation and by conversion to the corresponding hydroxy and methoxy flavoquinones. Simultaneous introduction of two hydroxyls o‐ and p‐ to an existing hydroxyl function can be a potential step‐saver in the synthesis of polyphenolic substances.