bluuebunny/crossref_metadata_2025_split huggingface dataset:
Female Preferences for Male Vocal and Facial Masculinity in Videos
Authors: O’Connor Jillian J. M. , Feinberg David R. , Fraccaro Paul J. , Borak Diana J. , Tigue Cara C. , Re Daniel E. , Jones Benedict C. , Little Anthony C. , Tiddeman Bernard 
Published: January 2012

AbstractVocal and facial masculinity are cues to underlying testosterone in men and influence women’s mate preferences. Consistent with the proposal that facial and vocal masculinity signal common information about men, prior work has revealed correlated female preferences for male facial and vocal masculinity. Previous studies have assessed women’s preferences for male facial and vocal masculinity by presenting faces and voices independently and using static face stimuli. By contrast, here we presented women with short video clips in which male faces and voices were simultaneously manipulated in masculinity. We found that women who preferred masculine faces also preferred masculine voices. Furthermore, women whose faces were rated as relatively more attractive preferred both facial and vocal masculinity more than did women whose faces were rated as less attractive. These findings complement other evidence for cross‐modal masculinity preferences among women and demonstrate that preferences observed in studies using still images and/or independently presented vocal stimuli are also observed when dynamic faces and voices are displayed simultaneously in video format.
The feeding effects of western flower thrips (Frankliniella occidentalis (Pergande)) and wind damage on French beans (Phaseolus vulgaris L.)
Authors: Harper Suzanne , Horne Paul A 
Published: January 2012

AbstractThe relative impact of feeding effects of thrips (Frankliniella occidentalis (Pergande)) and wind damage on French beans Phaseolus vulgaris L. was tested in a glasshouse simulation trial. Wind caused significantly more ‘bean‐curl’ and scarring to the pod than that caused by thrips. Bean growers in Tasmania, where much damage to bean pods has been attributed to thrips, should consider the use of wind breaks to prevent this damage and reconsider the use of insecticide regimes currently used to control thrips.
Clinical relevance of anti‐exenatide antibodies: safety, efficacy and cross‐reactivity with long‐term treatment
Authors: Fineman M. S. , Mace K. F. , Diamant M. , Darsow T. , Cirincione B. B. , Booker Porter T. K. , Kinninger L. A. , Trautmann M. E. 
Published: January 2012

Aims: Antibody formation to therapeutic peptides is common. This analysis characterizes the time‐course and cross‐reactivity of anti‐exenatide antibodies and potential effects on efficacy and safety.Methods: Data from intent‐to‐treat patients in 12 controlled (n = 2225,12–52weeks) and 5 uncontrolled (n = 1538, up to 3 years) exenatide twice‐daily (BID) trials and 4 controlled (n = 653,24–30weeks) exenatide once weekly (QW) trials with 1 uncontrolled period (n = 128,52weeks) were analysed.Results: Mean titres peaked early (6–22 weeks) and subsequently declined. At 30 weeks, 36.7% of exenatide BID patients were antibody‐positive; 31.7% exhibited low titres (≤125) and 5.0% had higher titres (≥625). Antibody incidence declined to 16.9% (1.4% higher titre) at 3 years. Similarly, 56.8% of exenatide QW patients were antibody‐positive (45.0% low/11.8% higher titre) at 24–30 weeks, declining to 45.4% positive (9.2% higher titre) at 52 weeks. Treatment‐emergent anti‐exenatide antibodies from a subset of patients tested did not cross‐react with human GLP‐1 or glucagon. Other than injection‐site reactions, adverse event rates in antibody‐positive and antibody‐negative patients were similar. Efficacy was robust in both antibody‐negative and antibody‐positive patients (mean HbA1c change: −1.0 and −0.9%, respectively, exenatide BID; −1.6% and −1.3% exenatide QW). No correlation between change in HbA1c and titre was observed for exenatide BID, although mean reductions were attenuated in the small subset of patients (5%) with higher titres. A significant correlation was observed for exenatide QW with no difference between antibody‐negative and low‐titre patients, but an attenuated mean reduction in the subset of patients (12%) with higher titres.Conclusions: Low‐titre anti‐exenatide antibodies were common with exenatide treatment (32% exenatide BID, 45% exenatide QW patients), but had no apparent effect on efficacy. Higher‐titre antibodies were less common (5% exenatide BID, 12% exenatide QW) and within that titre group, increasing antibody titre was associated with reduced average efficacy that was statistically significant for exenatide QW. Other than injection‐site reactions, anti‐exenatide antibodies did not impact the safety of exenatide.
TIMBER MONUMENTS, LANDSCAPE ANDTHE ENVIRONMENT IN THE NITH VALLEY, DUMFRIES AND GALLOWAY
Authors: MILLICAN KIRSTY 
Published: January 2012

SummaryThis paper considers the impact of landscape and environment upon monuments built during the Neolithic period. Taking a group of timber monuments of Neolithic date in the Nith Valley region, Dumfries and Galloway, it examines their relationship to the topography and environment and seeks to explain their uniquely linear nature, a feature of timber monuments built in this region. It discusses the importance of incorporating plough‐levelled sites into landscape approaches to monuments, the potential impact of vegetation upon visibility patterns, and the value of considering the immediate locations of monuments, arguing that monuments built upon a heightened awareness of landscape topography, arising out of a long‐term relationship with place.
THE RIVER HAS NEVER DIVIDED US: BRONZE AGE METALWORK DEPOSITION IN WESTERN BRITAIN
Authors: MULLIN DAVID 
Published: January 2012

SummaryThe significant quantities of Bronze Age metalwork recovered from the River Thames have focused archaeological attention on the presence of metalwork from riverine locations and led to the expectation that rivers should contain metalwork. Finds from bogs and marshes have also been considered to be part of this practice of deposition in ‘wet places’. Whilst rivers and bogs can indeed be thought of as ‘wet’, this overlooks the fundamental physical and cosmological differences between these two types of wetland. This paper will consider Bronze Age metalwork finds from rivers in the west of Britain, paying particular attention to Britain's longest river, the Severn. The finds will be compared to those from bogs and marshes, and an attempt will be made to explain these differences in terms of the opposing metaphorical qualities of flowing and standing water, and the landscapes in which these wet places are located.
Differences in acetabular morphology related to side and sex in a Chinese population
Authors: Zeng Yiming , Wang You , Zhu Zhenan , Tang Tingting , Dai Kerong , Qiu Shijing 
Published: January 2012

AbstractThe purpose of the present study was to determine the side and sex differences in acetabular dimension and orientation in normal Chinese adults, which are not known well but are important in hip joint replacement surgery. The acetabular parameters, including anteversion angle (AV.A), abduction angle (AB.A), center edge angle (CE.A), acetabular width (Ac.W) and acetabular depth (Ac.D), were measured on CT images in 100 healthy Chinese adults. The acetabular index of depth to width (Ac.D/Ac.W) was calculated by depth/width × 100. Percentage side difference (PSD) was calculated for each parameter. The absolute numbers of PSD (aPSD) were compared between the groups of right positive (right PSD > left PSD) and left positive (left PSD > right PSD) groups. There was no significant side difference in any of the parameters. Compared to men, a significant increase in AB.A (P = 0.001) and significant decreases in Ac.W (P < 0.001), Ac.D (P < 0.001) and Ac.D/Ac.W (P < 0.05) occurred in women. The differences in Ac.W and Ac.D became insignificant when adjusted for body height. aPSD did not show a significant difference between right and left positive groups in both sexes. In conclusion, the side differences in acetabular parameters in a normal individual are likely to be associated with measurement error. In addition, the larger acetabular dimension in men is attributed to greater body height independent of sex.
Variations in older persons’ descriptions of the burden of loneliness
Authors: Hauge Solveig , Kirkevold Marit 
Published: January 2012

Scand J Caring Sci; 2012; 26; 553–560Variations in older persons’ descriptions of the burden of lonelinessResearch indicates that approximately one‐third of older people over the age of 65 years report loneliness, with even higher rates among those aged over 85. Loneliness is associated with a variety of health issues, such as depression, anxiety, physical impairment and social isolation. The purpose of this paper is to describe the characteristics of the burden of loneliness, and investigate the variability in how it is described by older. In‐depth interviews were conducted with 12 older people in autumn 2006 and spring 2007 in Norway. Participants aged from 70 to 97 years were recruited from a variety of backgrounds, and varied in health status and social status. The findings reported in this paper are based on hermeneutic analyses of the interviews. Our findings indicate that some of the participants experienced loneliness that they felt able to manage. They experienced a fluctuating loneliness that was linked to feeling valuable and having power and energy. However, another group described experiences of agonising loneliness. They felt a present and extensive loneliness, together with feeling less valuable and lacking in power and initiative. They seemed trapped in their loneliness, and unable to overcome their situation themselves. Our findings indicate that the burden of loneliness is experienced differently. For some older persons, the experience of loneliness is so severe that they urgently need help to manage their situation.
The Interpretability of Family History Reports of Alcoholism in General Community Samples: Findings in a Midwestern U.S. Twin Birth Cohort
Authors: Waldron Mary , Madden Pamela A. F. , Nelson Elliot C. , Knopik Valerie S. , Glowinski Anne L. , Grant Julia D. , Lynskey Michael T. , Jacob Theodore , Sher Kenneth J. , Bucholz Kathleen K. , Heath Andrew C. 
Published: January 2012

Background:Although there is a long tradition in alcoholism research of using family history ratings, the interpretability of family history reports of alcoholism from general community samples has yet to be established.Methods:Telephone interview data obtained from a large cohort of female like‐sex twins (N = 3,787, median age 22) and their biological parents (N = 2,928, assessed at twins’ median age 15) were analyzed to determine agreement between parent self‐report, parent ratings of coparent, and twin narrow (alcohol problems) and broad (problem or excessive drinking) ratings of each parent.Results:In European ancestry (EA) families, high tetrachoric correlations were observed between twin and cotwin ratings of parental alcohol problems, between twin and parent ratings of coparent alcohol problems using symptom‐based and single‐item assessments, as well as moderately high correlations between twin and both mother and father self‐reports. In African American (AA) families, inter‐rater agreement was substantially lower than for EA families, with no cases where father ratings of maternal alcohol problems agreed with either twin ratings or mother self‐report, and both cotwin agreement and mother–twin agreement were reduced. Differences between EA and AA families were not explained by differences in years of cohabitation with father or mother's education; however, underreporting of problems by AA parents may have contributed.Conclusions:Results support the use of family history ratings of parental alcoholism in general community surveys for EA families, but suggest that family history assessment in AA families requires improved methods.
Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice
Authors: Yu Binglan , Lei Chong , Baron David M. , Steinbicker Andrea U. , Bloch Kenneth D. , Zapol Warren M. 
Published: January 2012

BACKGROUND: Stored red blood cells (RBCs) undergo progressive deleterious functional, biochemical, and structural changes. The mechanisms responsible for the adverse effects of transfusing stored RBCs remain incompletely elucidated.STUDY DESIGN AND METHODS: Awake wild‐type (WT) mice, WT mice fed a high‐fat diet (HFD‐fed WT) for 4 to 6 weeks, and diabetic (db/db) mice were transfused with syngeneic leukoreduced RBCs or supernatant with or without oxidation (10% of total blood volume) after storage for not more than 24 hours (FRBCs) or 2 weeks (SRBCs). Inhaled nitric oxide (NO) at 80 parts per million was administered to a group of mice transfused with SRBCs. Blood and tissue samples were collected 2 hours after transfusion to measure iron and cytokine levels.RESULTS: SRBCs had altered RBC morphology and a reduced P50. Transfusion of SRBCs into WT or HFD‐fed WT mice did not produce systemic hemodynamic changes. In contrast, transfusion of SRBCs or supernatant from SRBCs into db/db mice induced systemic hypertension that was prevented by concurrent inhalation of NO. Infusion of washed SRBCs or oxidized SRBC supernatant into db/db mice did not induce hypertension. Two hours after SRBC transfusion, plasma hemoglobin (Hb), interleukin‐6, and serum iron levels were increased.CONCLUSION: Transfusion of syngeneic SRBCs or the supernatant from SRBCs produces systemic hypertension and vasoconstriction in db/db mice. It is likely that RBC storage, by causing in vitro hemolysis and posttransfusion hemoglobinemia, produces sustained NO scavenging and vasoconstriction in mice with endothelial dysfunction. Vasoconstriction is prevented by oxidizing the supernatant of SRBCs or breathing NO during SRBC transfusion.
Unmanipulated HLA‐mismatched/haploidentical peripheral blood stem cell transplantation for high‐risk hematologic malignancies
Authors: Huang Wenrong , Li Honghua , Gao Chunji , Bo Jian , Wang Qunshun , Zhao Yu , Jing Yu , Wang Shuhong , Zhu Haiyan , Dou Liping , Wang Lili , Yu Li 
Published: January 2012

BACKGROUND: Haploidentical hematopoietic stem cell transplantation (HSCT) has been increasingly applied in high‐risk hematologic patients due to the absence of HLA‐matched donors. The aim of this study was to investigate the efficacy and safety of unmanipulated haploidentical allogeneic peripheral blood stem cells transplantation (PBSCT) for hematologic malignancies.STUDY DESIGN AND METHODS: Patients who underwent unmanipulated HLA‐mismatched/haploidentical PBSCT from July 2007 to March 2010 with high‐risk hematologic malignancies were enrolled for retrospective analysis.RESULTS: Twenty‐one patients with high‐risk hematologic malignancies underwent unmanipulated HLA‐mismatched/haploidentical PBSCT with myeloablative conditioning. The numbers of CD34+ cells infused at transplantation were 4.81 (range, 2.61‐11.47) × 106/kg. Patients achieved myeloid and platelet engraftment at a median of 16.5 and 20 days, respectively. The cumulative incidence of acute graft‐versus‐host disease (GVHD) on Day 100 was 52.7 ± 10.7%, and the 2‐year cumulative incidence of chronic GVHD was 39.5 ± 10.6%. The cumulative incidences of cytomegalovirus antigenemia and hemorrhagic cystitis within 100 days after PBSCT were 59.5 ± 16.7 and 34.8 ± 13.3%, respectively. One hundred‐day transplantation‐related mortality (TRM) rate and the 2‐year cumulative TRM rate were 14.3 and 20.5 ± 7.8%, respectively. The 2‐year cumulative overall survival was 62.1 ± 11.4% and the probability of disease‐free survival at 2 years was 55.6 ± 10.7% with a 16‐month median follow‐up.CONCLUSION: Unmanipulated PBSCT is a promising protocol in HLA‐mismatched/haploidentical transplant settings.
Twenty‐Fold Difference in Evolutionary Rates between the Mitochondrial and Plastid Genomes of Species with Secondary Red Plastids
Authors: Smith David Roy , Keeling Patrick J. 
Published: January 2012

AbstractWithin plastid‐bearing species, the relative rates of evolution between mitochondrial and plastid genomes are poorly studied, but for the few lineages in which they have been explored, including land plants and green algae, the mitochondrial DNA mutation rate is nearly always estimated to be lower than or equal to that of the plastid DNA. Here, we show that in protists from three distinct lineages with secondary, red algal‐derived plastids, the opposite is true: their mitochondrial genomes are evolving 5–30 times faster than their plastid genomes, even when the plastid is nonphotosynthetic. These findings have implications for understanding the origins and evolution of organelle genome architecture and the genes they encode.
Azathioprine‐induced EBV‐positive mucocutaneous ulcer
Authors: McGinness Jamie L. , Spicknall Kerith E. , Mutasim Diya F. 
Published: January 2012

Epstein‐Barr virus (EBV)‐positive mucocutaneous ulcer was recently described as a clinicopathologic entity occurring secondary to iatrogenic or age‐related immune suppression. The histopathology of EBV‐positive mucocutaneous ulcer reveals a polymorphous infiltrate including atypical large B‐cells and Reed‐Sternberg‐like cells which are CD20‐positive, CD30‐positive and EBV‐positive. The disorder follows an indolent and self‐limited course. We report a case of EBV‐positive mucocutaneous ulcer secondary to prolonged use of azathioprine for the treatment of pemphigoid and highlight the need for recognition of this disorder by dermatopathologists and dermatologists.McGinness JL, Spicknall KE, Mutasim DF. Azathioprine‐induced EBV‐positive mucocutaneous ulcer.
Comparison of two encapsulated curcumin particular systems contained in different formulations with regard to in vitro skin penetration
Authors: Suwannateep N. , Wanichwecharungruang S. , Fluhr J. , Patzelt A. , Lademann J. , Meinke M. C. 
Published: January 2012

BackgroundCurcumin is known for its anti‐inflammatory, antioxidative, and anticarcinogenic properties. However, the strong lipophilic compound is not easily applicable, neither in water, nor directly in o/w formulations. So far, loading of nano or micro scaled carriers has enabled only an uptake up to 30% of curcumin.MethodIn the present article, curcumin was successfully encapsulated into two different safe and inexpensive polymers, ethyl cellulose and methyl cellulose blended ethyl cellulose with a loading capacity of ~ 46–48%. In addition, the in vitro skin penetration of the two curcumin encapsulated particular systems, which were applied each in three different formulations, an o/w, w/o lotion, and water suspension, was investigated on porcine ear skin using Laser scanning microscopy.ResultsIt was found that in comparison to water suspensions, o/w and w/o lotions enhanced, especially the follicular penetration of the encapsulated curcumin particles into porcine skin, whereas the w/o enhanced the penetration better than the o/w lotion. Furthermore, the application of ethyl cellulose blended with methyl cellulose improved the penetration of curcumin in all formulations.ConclusionHigh loaded encapsulated curcumin systems, prepared from a simple and highly efficient encapsulation system can be used to transport curcumin effectively into the skin.
Gender‐dependent differences in degree of facial wrinkles
Authors: Tsukahara Kazue , Hotta Mitsuyuki , Osanai Osamu , Kawada Hiromitsu , Kitahara Takashi , Takema Yoshinori 
Published: January 2012

Background/purposeThis study aimed to reveal gender‐dependent differences in the degree of facial wrinkles.MethodsSubjects comprised 173 Japanese men and women, divided into four groups according to age. Photographs were taken from nine facial regions and used to classify the intensity of wrinkles into five grades. In addition, replicas were taken from five facial sites and used to measure surface roughness. Data were compared between men and women within each age group.ResultsIn all age groups, men showed increased forehead wrinkles compared with women. In contrast, no gender‐dependent differences were found in upper eyelid wrinkles. Other facial wrinkles were greater in men than in women in all except the oldest group (age, 65–75 years), in which wrinkles in women were greater than or equal to those in men.ConclusionOur results showed that gender‐dependent differences exist in the degree of facial wrinkles. In general, men tend to have more severe wrinkles than women. This tendency disappeared or was reversed in some regions of the face and in individuals more than 60 years old.
Correlation of Platelet Growth Factor Release in Jawbone Defect Repair – A Study in the Dog Mandible
Authors: Thor Andreas LI , Hong Jaan , Kjeller Göran , Sennerby Lars , Rasmusson Lars 
Published: January 2012

ABSTRACTBackground: Platelet concentrate/platelet‐rich plasma (PRP) has been studied extensively in various experimental models and there is some agreement among workers to its early effect in bone regeneration and healing. We have earlier showed in vitro that titanium in whole blood activates the thrombogenic response to a higher degree than PRP and that a fluoridated test surface augmented the effect compared with control.Purpose: We designed this study to evaluate the effect of PRP and whole blood on bone regeneration in a dog implant defect model and, in addition, the effect of a test surface modified in hydrofluoric acid. A correlation attempt between platelet count, release of growth factors, and bone regeneration was made.Materials and Methods: Six dogs were used and simultaneously with the experimental surgery and implant installation, autologous PRP was prepared. Defects were prepared (6 mm in diameter and 5 mm deep), and implants were installed (TiO2 gritblasted and hydrofluoric acid treated [test] or TiO2 gritblasted [control], 5 mm in diameter and 9 mm long) in defects filled with either PRP or whole blood. Randomization of sides between PRP and whole blood, and sites for test and control implants were made. Blood samples were collected from PRP and whole blood. The dogs were killed after 5 weeks of healing, and samples with implants and surrounding bone were collected and processed for analysis. Enzyme linked immunosorbent assays were used for detection of growth factors in PRP.Results: The mean increase of platelet count was 424% in PRP. A correlation for platelet counts and transforming growth factor β was found in each dog (r2 = 0.857). Approximately 50% of the region of interest (ROI) in the defects was filled with new bone after 5 weeks. No difference could be observed in ROI by using PRP or whole blood in the defects regarding new bone formation, bone in contact with implant, or distance to first bone contact. However, the fluoridated implants exhibited more new bone formation (p = .03) compared with control, regardless of comparing PRP or whole blood, and also displayed a shorter distance from first bone contact to the margin of the bone envelope (p = .05).Conclusions: Platelet concentrate/PRP failed to show more new bone regeneration in a peri‐implant defect model compared with whole blood. Implants treated with hydrofluoric acid displayed higher percentages of bone fill in the defect.