bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fat Tissue Peptides Do Not Differentiate Two Types of Anorexia Nervosa - the Preliminary Study
Authors: Kozik M. Janas , Stachowicz M. , Matuszczyk I. Krupka , Mazurek U. , Krysta K. , Jelonek I. 
Published: March 2009

The pathogenesis of AnorexiaNervosa (AN) is still not entirely understood. DSM-IV classification differentiates two AN types: the restricting type (AN-R) and the binge-eating/purging type (AN-BP). We investigated four young women suffered from AN (two with AN-R and two with AN-BP) and the other four were our control group who did not suffer from eating disorder. The oligonucleotide microarray method (HG-U133A, Affymetrix) was used to determine the expression profile of genes coding fat tissue protein. On the oligonucleotide microarray HG-U133A were analyzed 15 transcripts representing 9 fat tissue genes (leptin, resistin, tumor necrosis factor, adiponectin, angiotensinogen, interleukin 6, chemerin, visvatin and SERPINE 1), which are potentially involved in mechanism of food intake and energy balance.The total RNA was extracted from peripheral blood mononuclears. The oligonucleotide microarray method analyzes genes expression by using the phenomenon of hybridization of single-thread RNA fragments with complementary DNA probes. The results were normalized using RMAExpress. The U Mann-Whitney test was used for statistical analysis. The p < 0.05 was accepted as the essential level of statistical significance. Statistical analysis was measured by using Statistica version 7.1 PL.None of 15 transcripts coding fat tissue protein differentiate two type of AN: the restrictive type of AN and binge-eating type of AN (p=0.7901) and none of investigated transcripts differentiate either the restrictive type of AN and control group (p=0.7001) or binge-eating type of AN and control group (p=0.8641).The fat tissue protein did not seem to be responsible for food intake.
Intact: Individually Tailored Stepped Care for Women with Eating Disorders
Authors: Machado P. 
Published: March 2009

INTACT is a multi-disciplinary and inter-sectorial network of 9 European partners from 8 EU countries aiming at the development of new strategies for the prevention and treatment of eating disorders.Acknowledging that not all women at risk for an eating disorder actually develop the disorder and that not all of those who get ill need the same type and intensity of care, INTACT studies stepped care treatment and individually tailored interventions based on research into the process of getting ill, getting well, and staying well.The development of such innovative approaches in which treatments are provided sequentially according to patients’ needs promises to optimise health care for ED patients.Specifically, the INTACT studies focus on the development of:1.risk models,2.step-up interventions,3.therapy process-outcome models, and4.step-down interventions and apply methods from the fields of psychotherapy research, genetics, biology, linguistics and computer sciences.INTACT is funded by the European Commission (MRTN-CT-2006-035988).
Obesity and its Connections to Some Personality Traits, Locus of Health Control in Adolescents
Authors: Mojs E. , Gajewska E. , Samborski W. 
Published: March 2009

The substantial health enhancing potential of physical and psychological activity can be realized by incorporation of physical activity in everyday style of life. Health can be understood as an aim of activities but also adolescents may not take into consideration activities toward health improvement.The aim of the study was to estimate differences in psychological functioning locus of health control in adolescents with obesity.The method were: The Scale MHLC - Multidimensional Scale of Health Control Localization. CISS - questionnaire of coping with stress.60 persons growing with obesity (over 90 percentile) participated in investigations in age of 12-18 years. 100 healthy persons well-chosen made up the group of the reference under in relation to age, sex, educations. The results were important on the level 0,05.Results show that the locus of health control was internal in both groups, but internal locus in healthy group has appeared more often. Children with obesity had lower abilities of coping with stress in comparison to healthy ones.
Psychopathologic Disturbance of Patients with Exchange Obesity
Authors: Romanova I. 
Published: March 2009

We investigated clinical fenomenology of psychopathologic disturbance of patients, suffering affliction by a exchange obesity, the differentiated schemes of a psychotherapy are designed and influencing psychotherapeutic tactics on efficiency of complex therapy of this group patients is detected.92 patients were inspected with a exchange obesity with usage of the clinico-anamnestic data, research of the neurologic and mental statuses, research of a vegetative nervous system, psychological methods, electrophysiological research. In activity the conducted complex examination with usage of psychological methods also is studied influencing psychopathologic changes on a clinical picture of an obesity. The conducted correlation analysis psychopathologic and clinico-encephalografical of changes at exchange obesity. The values of an excess weight in frame of psychosomatic distresses are studied. The efficiency of emotional - stressful therapy is studied at the miscellaneous forms of an excess weight for the inspected patient's category.As a result of the conducted research the yardsticks of psychological diagnostic of patients exchange obesity are designed, and also complex of therapy with actuation of emotional - stressful psychotherapeutic influencing, which one in practice will increase efficiency of the help of the given category ill. The designed yardsticks of diagnostic and treatment enable to offer a number of the practical guidelines for an intrusion in practical activity of preventive entities.
Glucocorticoid Receptor Gene Polymorphisms in Italian Patients with Anorexia and Bulimia Nervosa
Authors: Nacmias B. , Cellini E. , Ricca V. , Castellini G. , Tedde A. , Bagnoli S. , Sorbi S. 
Published: March 2009

The etiopathogenesis of eating disorders (ED) is complex and poorly understood. The hypothalamic-pituitary-adrenal (HPA) axis, involved in the biological response to stress, could influence the onset and the course of ED.) Several variants in the Glucocorticoid receptor (GR) gene have been related to different metabolic parameters suggesting a possible role in ED. We studied if genetic variants of GR could represent potential risk factors for the development of Anorexia Nervosa (AN) and Bulimia Nervosa (BN).We investigated the distribution of several single nucleotide polymorphisms (SNPs) of the GR including N363S (rs6195), Er22/23EK (rs6189-6190), A/G SNP in exon 9beta (rs6198) and the intronic BclI polymorphism (rs41423247), in 118 Italian patients affected by AN and in 108 patients with BN. Moreover we studied 116 normal individuals and 177 obese subjects. The distributions of genotypes and allele frequency of the SNPs in all studied groups followed Hardy-Weinberg equilibrium and did not significantly differ from that of controls. A trend towards association was observed in case-control association analysis (p=0.07) for rs6198. A correlation of metabolic parameters to the GR genotypes was performed.We report the analysis of different GR SNPs for the first time in Italian patients with AN and BN. We failed to detect an allelic association between the studied SNPs in the GR gene and AN and BN.None of the variants seems to influence these pathologies, not supporting a role for the GR gene as genetic risk factors for ED.
Evaluation of Coexisting Psychiatric Conditions in Women with Bulimia Nervosa and Partial Bulimia, Eating Disorder Not Otherwise Specified
Authors: Naessén S. , Carlström K. , Hirschberg A. Lindén 
Published: March 2009

Objective:The classification of eating disorders has been a matter of debate. Recent research indicates the clinical significance of eating disorder not otherwise specified (EDNOS). However, EDNOS is defined by exclusion, i.e.that not to fulfil criteria for anorexia nervosa (AN) or bulimia nervosa (BN). The aim of the present study was to compare bulimic behavior and psychiatric diagnosis in women with BN and EDNOS.Methods:All participants fulfilled the diagnosis according to DSM-IV. Women with BN (purging type, n=34) and age and body mass index matched women with EDNOS (n=31) were examined with respect to clinical condition, bulimic behaviour, purging methods and coexisting psychiatric conditions such as depression, anxiety disorders.Results:Apart from expected differences in binge eating and compensatory behavior, there were no differences between the two groups. Women with BN had higher scores for weight fobia, previous attempt to commit suicide, impulsive behaviour other than theft, and disturbed impulse control than women with EDNOS, while there were no differences in ten other psychiatric items such as depression, anxiety.Conclusions:Individuals with partial bulimia (EDNOS) seem to have the same spectrum of psychiatric diagnosis as women with BN even though they fail to meet diagnostic criteria for frequency of binge eating. There is a need to further specified the diagnostic criteria for BN.
Cognitive Disorders in Hospitalized Adolescent Anorectic and Bulimic Patients
Authors: Namyslowska I. , Remberk B. , Krempa-Kowalewska A. 
Published: March 2009

Objective:The problem of cognitive dysfunction in eating disorders remains controversial and the research results are not univocal. Because of that, research was undertaken on a homogenous group of young patients suffering from eating disorders, hospitalized in the adolescent unit.Method:The cognitive functions were assessed by Wisconsin Card Sorting Test (WCST) and Digit Span Test in the group of 60 adolescent girls (30 anorectic, 30 bulimic) of the same age and compared with the control group of 39 healthy adolescent girls. Also the relation of cognitive disorders with some clinical features of the illness such as the degree of weight loss, BMI at the admission and discharge and the results of EDI test were assessed.Results:Research results did not show statistically significant differences in the performance in the WCST between anorectic and bulimic patients and the control group. However, the group of anorectic patients show the tendency to perform worse in some parameters of WCST (TA, TE, PE, %PE, %CLR) than the control group, althought the results do not reach statistical significance. The results of the bulimic patients were better (p=0.04) than the control group in the Digit Span Test.No correlation was found between clinical data and results in WCST in eating disorder groups of patients while the correlation was found between results of Digit Span Test and BMI at admission in both clinical groups.Conclusions:The research does not fully confirms that patients suffering from eating disorders show deficits in cognitive functions.
Decision to Admit and Aims of Hospitalization in the Treatment of Eating Disorders: Making Sense of a Seven Years Experience
Authors: Nunes P. , Duarte-Silva S. , Brandão I. , Roma-Torres A. 
Published: March 2009

Eating disorders are one of the most intriguing and challenging psychiatric illnesses.Treatment recommendations for eating disorders are still based heavily on expert clinical judgment instead of on scientific evidence from controlled trials.According to APA's 2006 Practice Guidelines, patient's level of care is determined considering overall physical condition, psychology, behavior, and social circumstances, rather than simply relying on one or more physical parameters, such as weight. Of the five levels of care proposed, inpatient treatment is considered the last resort.Therefore, inpatient treatment should not be intended to replace outpatient treatment, but to precede and prepare for long-term recovery.The decision to hospitalize is usually based on several criteria, including medical (e.g. severe weight loss, significant psychiatric comorbidity), psychotherapeutic (e.g. lack of response to outpatient treatment) and psychosocial criteria (e.g. marked family disturbance). Indeed, hospitalization may have its own positive indications, especially when a supporting and stimulating therapeutic milieu is offered.The primary aim of this study is to characterize a group of 97 eating disorders inpatients admitted in Hospital São João Psychiatry Department between 2000 and 2007, respecting gender, age, diagnosis, previous treatment length, motive for hospitalization and its duration, BMI and number of hospitalizations. Secondarily, significant correlations will be explored and further discussed.
Expressed Emotion and Patient Psychopathology in Eating Disorders
Authors: Santos L. Rodríguez , Vaz Leal F.J. , Fuentes M.I. Ramos , Moreno M.J. Cardoso , Sánchez N. Fernández 
Published: March 2009

Objectives:To isolate clinical predictors of Expressed Emotion (EE) in relatives of patients with eating disorders.Methods:Forty-three families of patients with anorexia and bulimia nervosa were assessed using the Camberwell Family Inventory (CFI). In addition, the eating symptoms, the general psychopathology and the personality of the patients was assessed using the Eating Disorders Inventory (EDI-II), the Symptom Checklist (SCL-90-R) and the Structured Clinical Interview for the Diagnosis of Axis II DSM-IV Disorders (SCID-II). Binary logistic regression methods (Forward Wald) were used for statistical analysis.Results:Maturity fear, depressive features and anxiety of patients were predictors of parental EE level.Conclusion:Althoug more clinical research is needed, the results of our study suggest that the severity of the symptomathology and some personality features of the patients with eating disorders can influence the EE observed in their relatives.
Neurobiological and Clinical Predictors of Impulsivity in Bulimia Nervosa [P02-69]
Authors: Vaz Leal F.J. , Santos L. Rodríguez , Fuentes M.I. Ramos , Moreno M.J. Cardoso , Sánchez N. Fernández 
Published: March 2009

Objective:The main aim of this study was to analyze the association between a set of neurobiological/clinical factors and impulsivity in patients suffering from bulimia nervosa, as well as the capability of this factors to predict the severity of impulsivity.Methods:The Impulsive Behaviors Scale (IBS), the Diagnostic Interview for Bordeline Patients - Revised (DIB-R), the Beck Depression Inventory (BDI), the Millon Multiaxial Clinical Inventory (MMCI-II) and the Family Environment Scale (FES) were applied to 70 female patients with DSM-IV BN (purging subtype). Twenty-four hour urinary excretion of norepinephrine (NE), 3-methoxy-4-hydroxyphenylglycol (MHPG), serotonin (5-HT), 5-hydroxi-indol-acetic acid (5-HIAA), dopamine (DA), homovallinic acid (HVA), and morning serum cortisol levels before and after the administration of 1 mg of dexamethasone were determined.Results:Impulsivity was associated to lower levels of urinary 5-HT and 5-HIAA, borderline features, and lower family expressed emotion.Conclusions:The consideration of impulsivity as a core clinical feature in patients with bulimia nervosa could lead us to identify clinical subtypes of patients, with specific clinical profiles and specific treatment needs.
Eating Behaviour and Perfectionism in Students: A Prospective Study [P02-72]
Authors: Soares M.J. , Maia B. , Pereira A.T. , Gomes A. , Marques M. , Valente J. , Pato M. , Azevedo M.H. , Macedo A. 
Published: March 2009

Aim:To investigate the role of perfectionism in the development of disordered eating behaviours.Method:382 female university students completed the Hewitt & Flett MPS and the EAT-40 at baseline, one year after (T1) and two years later (T2).Results:Perfectionism at baseline was significantly associated with long-term abnormal eating attitudes/behaviours. Self-Oriented Perfectionism (SOP) and Socially Prescribed Perfectionism (SPP) were significant predictors of disordered eating behaviours. SOP at baseline was predictive of diet concerns, at T1 and T2. Baseline SPP was correlated with overall eating disturbance at T1 and T2. Regression analysis revealed that only SPP was a significant predictor of bulimic behaviours and social pressure to eat at T1, but not at T2.Conclusion:Our findings contribute to a more clear understanding of the association between perfectionism and eating disorders. SOP and SPP were prospectively associated with abnormal eating attitudes/behaviours and SOP was found to be predictive of diet concerns.
The Health Locus of Control in Anorexia Women
Authors: Wojciak R.W. , Mojs E. , Cierpialkowska L. 
Published: March 2009

The Multidimensional Health Locus of Control Scale (MHLC) designed by Wallston, Wallston, and DeVellis (1978) belongs to the most popular tests, assessing the health locus of control in respondents on three levels: internal, external, and accidental. The MHLC is used in health promotion programs, in prophylaxis effect. According to authors, the background of this conception is the conviction that internal locus of health control favours pro-health behaviour like taking physical activity, reduce smoking and alcohol drinking, weights control, HIV protection etc. In this preliminary study we would like to exam the health locus of control in anorexia women.The MHLC was curry out in 15 anorectic women (diagnosed by EAT-26) and 39 non-anorectic women, aged 21,7 ± 1,0 years. The results were analysed with the use the Chi-square test.We found the statistically significance differences between anorectic and non-anorectic women in the health locus of control (p< 0,001; Chi=13,24). However, the most of subjects (non-anorectic vs. anorectic, respectively 69% vs. 60%) located the health control inside, more anorectic felt that control on their health depend on the accidence than non-anorectic (respectively, 20% vs. 5%).The results of this preliminary study could suggest that the health locus of control may play the important role in initiate the anorexia behaviour in women.
Different Subtypes of Anorexia Nervosa in Adolescent Patients
Authors: Zechowski C. , Namyslowska I. , Bragoszewska J. , Witkowska M. 
Published: March 2009

Aim:Proper diagnosis and choice of adequate treatment have essential influence on the course and prognosis in eating disorders. Resent research (Thompson-Brenner, Eddy, Satir, Boisseau, Westen 2008) and our clinical practice (Jakubczyk, Zechowski, Namyslowska 2003) has shown that anorectic patients are not homogenous group, and they differ in the character of clinical symptoms and personality profile. Aim of the study is differentiation of anorexic patients on the basis on personality pathology, comorbidity and outcome.Methods:50 hospitalized anorexic adolescent girls (14-19 y.o.) were investigated by SWAP-200-A procedure, EDI, YBOCS, STAI, GAF, Hamilton Scale, Beck Scale, PAS, Developmental Impairment Questionnaire. Authors also assessed parameters of outcome such as a body mass change (kg/BMI), recurrence of menses, pharmacotherapy, kind of therapy preferred by patients and length of hospital treatment.Results:Preliminary results revealed three subgroups of anorexic patients different in personality pathology (well functioning/perfectionist, emotionally deregulated and avoidant), comorbidity and outcome. (Detail description of the study will be presented at the conference).Conclusions:The study confirms clinical observations and the results of other studies that there are three groups of anorexic patients different in clinical symptoms, comorbidity and profiles of personality.
Can Salivary Cortisol Assessment from a Single HF-rTMS Session Predict Clinical Outcome in Melancholic Depressed Patients? A Pilot Study
Authors: Baeken C. , Santermans L. , Zeeuws D. , de Raedt R. , Vanderbruggen N. 
Published: March 2009

Aim:The underlying physiological mechanisms as to why repetitive transcranial magnetic stimulation (rTMS) can treat depressed patients remains unclear and no clear biological markers are available to indicate a positive outcome for a given patient. Some data suggest that rTMS can influence hypothalamic-pituitary-adrenal (HPA) processes. In this study, we wanted to evaluate whether one session of high frequency (HF)-rTMS applied on the left dorsolateral prefrontal cortex (DLPFC) can predict a successful treatment outcome in a sample of antidepressant free unipolar depressed patients of the melancholic subtype.Methods:Twenty one right-handed treatment resistant depressed patients were studied. Fifty two percent of the patients were considered as treatment responders, as defined by a 50% reduction in her/his baseline 17-item Hamilton Depression Rating Scale (HDRS) score. To examine acute HF-rTMS effects on the HPA- axis, we analyzed salivary cortisol levels, using a sham-controlled, ‘single’ blind, crossover design. Areas under the curves (AUC) were calculated for both real and sham HF-rTMS.Results:Real HF-rTMS resulted in salivary cortisol decreases, however only in HF-rTMS non-responders. No HF-rTMS influences were found in the responder group. Sham stimulation did not affect the HPA-axis. Non-responders were found to display a higher level of co-morbid personality disorders.Conclusion:Our results may provide more insight into the underlying working mechanisms of HF-rTMS and could add further information about endocrinological functioning in affective disorders. Furthermore, personality features in combination with a ‘super-sensitive’ HPA system could be of importance to predict clinical outcome.
Transcranial Magnetic Stimulation for Borderline Personality Disorder: Rationale, Stimulation Site and Methods
Authors: Cailhol L. , Bui E. , Roussignol B. , Moncany A.-H. , Klein R. , Simonetta-Moreau M. , Thalamas C. , Birmes P. , Schmitt L. 
Published: March 2009

Borderline personality disorder (BPD) is characterized by pervasive instability in moods, interpersonal relationships, self-image, and behavior. This disorder is associated with a significant rate of suicide attempts and completed suicides (4 to 10%), a major impairment in social functioning and an increased healthcare utilization cost. Treatments available include psychotherapy and pharmacotherapy. Research has shown some efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) on post-traumatic stress disorder and mood disorder which both share common biological or clinical features with BPD. It is then likely that rTMS might prove efficient on BPD symptoms.A review of the literature on neuroimaging and neuropsychology of BPD shows a hypoactivity of the dorsolateral prefrontal cortex which may be a potential target site for rTMS.We will conduct a pilot randomized sham-controlled trial on 30 BPD patients assessing the efficacy of a 10-day course of daily rTMS on neuropsychological tasks, BPD symptoms severity, risk taking behaviour, depression and general psychopathology.