bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kazimierza Kłósaka odczytanie i ocena stanowiska Pierre’a Teilharda de Chardin w kwestii powstania człowieka i jego natury
Authors: Maziarka Tomasz 
Published: May 2024

Artykuł jest próbą odpowiedzi na pytanie, w jaki sposób Kazimierz Kłósak odczytywał i interpretował poglądy Pierre’a Teilharda de Chardin w kwestii powstania człowieka i jego natury. Ukazuje on, że chociaż krakowski filozof popularyzował w Polsce twórczość francuskiego przyrodnika, to jednak niekiedy z nim polemizował i swoiście go interpretował. Kluczowym zagadnieniem była próba zrozumienia aktu stworzenia przez Boga duszy ludzkiej w kontekście ewolucji. Odpowiedź Teilharda brzmiała, że dusza ludzka wykształciła się na drodze ewolucji, gdyż duch egzystował w pramaterii; odpowiednie złożenie materii wygenerowało zjawiska duchowe. Chociaż Kłósak próbuje obronić Teilharda przed zarzutem o materializm, ostatecznie nie udaje mu się ocalić go dla ortodoksji. Zgodnie bowiem z klasycznym twierdzeniem, określonym przez św. Tomasza z Akwinu i popieranym przez Kłósaka, dusza ludzka została stworzona z nicości własnej i nicości podmiotu (ex nihilo sui et subiecti). W ujęciu Teilharda dusza ludzka powstała z duszy zwierzęcej, a więc powstała z nicości własnej, ale nie z nicości podmiotu. Rozwiązanie Teilharda nie jest więc „stworzeniem” w ścisłym tego słowa znaczeniu. Na kanwie głównego wątku artykuł podejmuje ważne kwestie metodologiczne dotyczące badania problemu początków człowieka i stworzenia duszy ludzkiej.
Single-Cell Transcriptional Signatures of Glomerular Disease in Transgenic Mice with APOL1 Variants
Authors: Yoshida Teruhiko , Latt Khun Zaw , Santo Briana A. , Shrivastav Shashi , Zhao Yongmei , Fenaroli Paride , Chung Joon-Yong , Hewitt Stephen M. , Tutino Vincent M. , Sarder Pinaki , Rosenberg Avi Z. , Winkler Cheryl A. , Kopp Jeffrey B. 
Published: May 2024

Key Points

Apolipoprotein L1 (APOL1)-G1 induced kidney disease in the two APOL1 transgenic mouse models, HIV-associated nephropathy and IFN-γ administration.Glomerular single-nuclear RNA-sequencing identified genes differentially expressed among mice with APOL1-G1 and G0 variants at single-cell resolution.

Background
Apolipoprotein L1 (APOL1) high-risk variants contribute to kidney disease among individuals with African ancestry. We sought to describe cell-specific APOL1 variant–induced pathways using two mouse models.

Methods
We characterized bacterial artificial chromosome/APOL1 transgenic mice crossed with HIV-associated nephropathy (HIVAN) Tg26 mice and bacterial artificial chromosome/APOL1 transgenic mice given IFN-γ.

Results
Both mouse models showed more severe glomerular disease in APOL1-G1 compared with APOL1-G0 mice. Synergistic podocyte-damaging pathways activated by APOL1-G1 and by the HIV transgene were identified by glomerular bulk RNA sequencing (RNA-seq) of HIVAN model. Single-nuclear RNA-seq revealed podocyte-specific patterns of differentially expressed genes as a function of APOL1 alleles. Shared activated pathways, for example, mammalian target of rapamycin, and differentially expressed genes, for example, Ccn2, in podocytes in both models suggest novel markers of APOL1-associated kidney disease. HIVAN mouse-model podocyte single-nuclear RNA-seq data showed similarity to human focal segmental glomerulosclerosis glomerular RNA-seq data. Differential effects of the APOL1-G1 variant on the eukaryotic initiation factor 2 pathway highlighted differences between the two models.

Conclusions
These findings in two mouse models demonstrated both shared and distinct cell type–specific transcriptomic signatures induced by APOL1 variants. These findings suggest novel therapeutic opportunities for APOL1 glomerulopathies.
Complement Terminal Pathway Activation and Intrarenal Immune Response in C3 Glomerulopathy
Authors: Meuleman Marie-Sophie , Petitprez Florent , Pickering Matthew C. , Le Quintrec Moglie , Artero Mikel Rezola , Duval Anna , Rabant Marion , Gilmore Alyssa , Boyer Olivia , Hogan Julien , Servais Aude , Provot François , Gnemmi Vivianne , Eloudzeri Maeva , Grunenwald Anne , Buob David , Boffa Jean-Jacques , Moktefi Anissa , Audard Vincent , Goujon Jean-Michel , Bridoux Frank , Thervet Eric , Karras Alexandre , Roumenina Lubka T. , Frémeaux Bacchi Véronique , Duong Van Huyen Jean-Paul , Chauvet Sophie 
Published: May 2024

Key Points

We evidenced terminal pathway activation (C5b-9 deposits) in most of the glomeruli on kidney biopsy of C3 glomerulopathy.The amount of C5b-9 deposits correlated with disease prognosis in C3 glomerulopathy.Increased terminal pathway activation was found predominantly in a subgroup exhibiting an immuno-fibroblastic signature.

Background
C3 glomerulopathy is a rare disease resulting from an overactivation of the complement alternative pathway. Although there is also evidence of terminal pathway activation, its occurrence and consequences on the disease have been poorly studied.

Methods
We retrospectively studied a cohort of 42 patients diagnosed with C3 glomerulopathy. We performed centralized extensive characterization of histological parameters. Kidney C5b-9 staining was performed as a marker of terminal pathway activation; intrarenal immune response was characterized through transcriptomic analysis.

Results
Eighty-eight percent of biopsies showed C5b-9 deposits in glomeruli. Biopsies were grouped according to the amount of C5b-9 deposits (no or low n=15/42, 36%; intermediate n=15/42, 36%; and high n=12/42, 28%). Patients with high C5b-9 deposits significantly differed from the two other groups of patients and were characterized by a significant higher histological chronicity score (P = 0.005) and lower outcome-free survival (P = 0.001). In multivariable analysis, higher glomerular C5b-9 remained associated with poor kidney prognosis after adjustment. One third of the 847 studied immune genes were upregulated in C3 glomerulopathy biopsies compared with controls. Unsupervised clustering on differentially expressed genes identified a group of kidney biopsies enriched in high glomerular C5b-9 with high immune and fibroblastic signature and showed high chronicity scores on histological examination.

Conclusions
In a cohort of patients with C3 glomerulopathy, intrarenal terminal pathway activation was associated with specific histological phenotype and disease prognosis.
Empirical Testing of the Hypothesis on the Structure of the Function of Private Savings in Russia
Authors: Rudyakov Vasilii 
Published: May 2024

The article deals with a topical issue of the discrepancies between savings and real investments in national economy. In the majority of theoretical models of contemporary neoclassical approach such nonequilibrium phenomena are of a purely temporary nature and a short term. However, the author having studied the data of twenty leading economies of the world shows that this discrepancy within the frameworks of capital formation is a rule for a long term but not an exception. The article presents the key findings of saving processes analysis in the Russian economy from 2000 to 2020 years based on the data of national statistics and the Bank of Russia. For research purposes the author introduces analytical categories — savings hoards, propensity to savings hoards and propensity to hoard. These very categories are put in the basis of the hypothesis on private national savings structure. Using post-Keynesian methodology and as a result of empirical analysis the author proves all the parts of the proposed hypothesis — gross private savings have sustained dependence from derived income; a part of savings is hoarded from consideration of “liquidity preference” and the share of such savings functionally depends on fluctuations in economic uncertainty (but not from economy’s absolute value); for Russian Federal subjects precautionary motive prevails over profit motive when allocating the savings base.
Conceptual differences about willingness of body donation among southern, eastern, central and northern population of India: Single centered approach
Authors: Aricatt Divia Paul , Khan Diwan Mahmood , Saxena Varsha , Ghaffar Abdul , Chandy Dane 
Published: May 2024

: Cadaveric dissection cannot be compensated by virtue table concepts or computerized learning aids. The present study was aimed to evaluate the conceptual differences and perceptional clarity about willingness of body donation relevant to regional practice among four inter-state population of India. The study objectives focused to assess the understanding level about general and special concepts and attitudes about body donation in Southern, Eastern, Central as well Northern parts of India and to compare differences about the concepts of understanding and willingness about body donation between four inter-state populations.A cross-sectional single center study with a differential rating scale questionnaire was conducted. Four hundred participants equally divided among four medical colleges of Southern, Eastern, Central and Northern India were the samples. All ethical principles for human research were followed. Completing a special course of ethical training and non-willingness to participate in the study were regarded as the criteria of a subject to get excluded from the study.The given questionnaire was completed by various participants from different zones: eastern, western, central and southern. We found significant difference in the educational level of the participants across various zones. Unsurprisingly, most likely due to the literacy rate, participants from the south are much more familiar with ‘body donation’ for research and education compared to participants from other three zones. Provisions to improve the body donation should concentrate on multi-directional tasks.
Radiological study of carrying angle among male and female and its clinical importance
Authors: Prabhakar T , Gurram Vinodkumar 
Published: May 2024

: The long axes of the ulna and humerus form an acute angle when the upper limb is in its anatomical position and the elbow is fully extended is known as the carrying angle. It is typically larger in females than in males Anthropologists use the carrying angle to predict a person's sex; orthopaedic surgeons use it to surgically treat a variety of elbow disorders; and total elbow prosthetics. The study aimed to assess the carrying angle in an attempt to determine its value in both sexes, proposing a simple and reliable method for measuring it.The elbow radiographs taken in the normal anteroposterior and lateral views were assessed independently and uniformly by anatomists. A total of 70 adult radiographs between the ages of 18 to 76 years, 35 males and 35 females were gathered. To measure the angle, two lines were drawn: one along the mid-axis of the upper limb of the forearm, passing between the radius and ulna through the superior radioulnar joint, and the other along the mid-axis of the lower third of the humerus, where the angle is measured.The carrying angle is statistically more significant in females than in males among 70 radiographs. The p-value was 0.000 and the mean and SD for males were 14.3±2.740, while the mean and SD for females were 21.92±3.170.The current study concludes that there is a significant gender difference between females and males; carrying angle influences secondary sexual characteristics.
ESSAY ON THE LANGUAGE SITUATION IN THE UKRAINIAN DANUBE REGION
Authors: Novak Olga M. 
Published: May 2024

The purpose of the study is to outline the current language situation in one of the multiethnic, and, accordingly, multilingual and multicultural regions of Ukraine — Budzhak. The Research objectives are: a) to identify the main differential features of the language situation in the region; b) to identify the components of the language situation — idioms that interact in the studied region; c) to identify the functional load of idioms in everyday and official communication; d) to study the influence of standard (literary) languages on dialect systems. The object of the study is the language situation in one of the region of Ukraine; the subject of the study is the structure and peculiarities of the modern language situation in the multiethnic region of the Ukrainian Danube. Conclusions. In the studied region the language situation is complex, exoglossic (idioms (dialects) of different languages interact: Bulgarian, Gagauz, Albanian, Moldovan (Romanian), Ukrainian, Russian, etc.); endoglossic (dialects and standard languages compete); unbalanced (components are functionally unequal and are distributed by spheres of use). Ukrainian serves as a language of official communication and education, while Russian serves as a lingua franca and informal communication. We see the prospect of further research in the study of interlingual interaction, mixed dialects and regionalisms. We consider it necessary and urgent to draw up a programme of comprehensive sociolinguistic research of the region as a model that can be used in other multiethnic regions in order to improve language planning and language policy of the state in general.
Index Card Match Boosts Math Learning by 84.2%
Authors: Tikasari Della Ajeng , Setiyawati Enik 
Published: May 2024

This study examines the effectiveness of the Index Card Match (ICM) learning model on fifth-grade mathematics education at SDIT Ainul Yaqin. Using a pre-experimental design, 20 students were selected through purposive sampling. Test sheets were used to measure learning outcomes, and data analysis included testing for normality and calculating N-Gain scores. The results showed a significant 84.2% improvement in mathematics learning outcomes, indicating the positive impact of the ICM model on student achievement. This research contributes to understanding innovative teaching methods' efficacy in enhancing elementary mathematics education. Highlight: Effective Math Learning: Evaluating Index Card Match model in fifth-grade math education. Pre-Experimental Design: Utilizing purposive sampling to assess teaching model impact. Notable Improvement: 84.2% increase in math learning outcomes observed. Keyword: Index Card Match, Mathematics Education, Elementary School, Learning Outcomes, Innovative Teaching Methods.
New Finding From Historical Data on Elementary Electric Charge May Provide Path Toward Ultraviolet Completion in the Standard Model
Authors: Williams Lamont 
Published: May 2024

Abstract

In many early studies of the value of elementary electric charge (e), experimentalists identified what appeared to be substantial discrepancies among results. Some discrepancies were explained; some were not. This investigation provides evidence suggesting that some discrepancies among experimental findings for the value of e may have been the result of there being discrete, naturally occurring categories of zero-energy values for the constant. These categories appear to be distinguishable from one another by way of a specific, basic equation, showing for the first time, a fundamental mathematical link among seemingly disconnected and discrepant experimental results concerning the value of e. It is further shown that the same equation may help to identify a fundamental equation for the fine-structure constant (α), shed some light on the nature of the logarithmic singularity that emerges in some studies seeking an asymptotically safe Standard Model extension, and ultimately provide a roadmap for solving the Landau pole problem and achieving ultraviolet completion in the Standard Model.
Oxygen delivery and monitoring in neonatal intensive care units in Mexico in 2011 and in 2023
Authors: ROMERO LUZ CONSUELO ZEPEDA , DE LEON JUAN CARLOS BARRERA , CRUZ VALERIA ALEJANDRA SALAS , BOUZO DAVID BLANCO , PADILLA JOSE ALFONSO GUTIERREZ , GILBERT CLARE 
Published: May 2024

Abstract

Background
Retinopathy of prematurity (ROP) is a leading cause of preventable blindness, notably in Latin America, with hyperoxia as a significant risk factor. This study evaluates the resource availability and utilization for administering and monitoring supplemental oxygen in Mexico.
Methods
In 2011, an observational study examined 32 government neonatal intensive care units (NICUs) across Mexico, recording data on occupancy, staffing levels, and oxygen delivery and monitoring equipment. Preterm infants receiving supplemental oxygen were observed. In 2023, 13 NICUs were revisited, and similar data were gathered. Staffing levels were benchmarked against recommendations from Argentina and the US.
Results
In 2011, only 38% of NICUs had adequate medical and staffing levels to meet recommended cot-to-staff ratios for all shifts. Ratios were poorer on weekends and at night. Only 25.5% of cots had blenders, and 80.1% had saturation monitors. Of 153 observed infants, 87% were monitored, with 53% exhibiting high oxygen saturation (≥96%) and 8% low saturation (≤89%). Alarm settings were inadequate, with 38% and 32% of upper and lower alarms switched off and 16% and 53% incorrectly set, respectively.
In the 13 NICUs with data from 2011 and 2023, cot-to-staff ratios deteriorated over time, with no unit achieving recommended ratios for all shifts in 2023. Equipment provision remained consistent, with similar rates of baby monitoring (79% in 2011; 75% in 2023). High oxygen saturation rates decreased slightly from 54% in 2011 to 49% in 2023. More upper alarms were set (46% in 2011; 75% in 2023), but a higher proportion were incorrectly set (52% in 2011; 68% in 2023).
Conclusions
Between 2011 and 2023, cot-to-staff ratios worsened, and equipment for safe oxygen delivery and monitoring remained insufficient. Despite available monitoring equipment, oxygen saturations often exceeded recommended levels, and alarms were frequently not set or incorrectly configured. Urgent improvements are needed in healthcare workforce numbers and practices, along with ensuring adequate equipment for safe oxygen delivery.
The fertility of a sub-population of stallions is negatively affected by ambient climatic conditions, mediated through DNA damage
Authors: Griffin Roisin , Miller Kasey , Colyvas Kim , Sheridan Alecia , De Iuliis Geoffry , Aitken Robert John , Baker Mark A. , Gibb Zamira , Swegen Aleona 
Published: May 2024

Abstract

Exposure to systemic heat stress in mammals adversely affects sperm production, male fertility, and DNA integrity. To date, few studies have investigated this phenomenon in horses, particularly in industry-relevant environments. Therefore, this study examined the relationship between ambient climatic conditions and fertility within a population of commercially fertile stallions. Post-coital semen samples were collected weekly from 46 Thoroughbred stallions during the 2017 and 2018 breeding seasons (n = 804). Sperm concentration, motility and DNA damage were assessed, and fertility statistics (first cycle and per-cycle pregnancy rates) were collected. Loggers were placed in the stables and paddocks of stallions to record ambient temperature and humidity, on 3-min cycles. Our results indicate that current management regimens, involving the stabling of stallions at night, with paddock access during the day, expose stallions to highest ambient climatic conditions. Polynomial distributed lag modelling identified 18 stallions whose fertility was adversely affected by heat stress, based on correlations between fertility and ambient climatic conditions (p ≤ 0.05). Of these 18-candidate stallions, six (13% of the overall population) exhibited repeated positive relationships between ambient climatic conditions and sperm DNA damage, while repeated negative relationships between fertility and sperm DNA damage (r ≥ 0.50; p ≤ 0.05). These results suggest that heat-induced subfertility is most likely mediated via oxidative damage to the sperm DNA, and that current management strategies should be assessed to prevent exposure of stallions to maximal climatic conditions.
Population structure and selective signature analysis of local sheep breeds in Xinjiang, China based on high-density SNP chip
Authors: Li Yanhao , Li Xiaopeng , Han Zhipeng , Yang Ruizhi , Zhou Wen , Peng Yuwei , He Jianzhong , Liu Shudong 
Published: May 2024

Abstract

The frigid and droughty climate of Xinjiang in China has given rise to unique indigenous sheep breeds with strong adaptability and resistance. In order to investigate the genetic mechanism of adaptability of Xinjiang sheep to local extreme environment, We conducted population genetic structure analysis for three native Xinjiang sheep breeds, Altay sheep (ALT), Bashbay Sheep (BSBC) and Duolang sheep (DLC), and two foreign sheep breeds, Suffolk and Dorset, using the Ovine Infinium HD SNP BeadChip(680K). The results indicate that Xinjiang sheep and foreign sheep have completely different genetic and evolutionary histories. Principal component analysis (PCA) and phylogenetic tree can distinguish the five sheep breeds based on their different geospatial positions, and the domestication level of Xinjiang sheep is lower than that of foreign sheep breeds. In addition, we obtained 459 genes in total by using two selection signal scanning methods, the fixation index (Fst) analysis and the cross-population extended haplotype homozygosity test (XP-EHH). Through enrichment analysis, candidate genes related to fat and energy metabolism (PID1, VEGFA, and PCBP2, et al.), reproduction (HDAC1, BMP5, and GDF9, et al.), as well as additional candidate genes pertaining to sheep's other environmental adaptability (ATF6, NFIB, and VIL1) have been discovered. This study provides a basis for the protection and utilization of local sheep germplasm resources in Xinjiang, and offers molecular data references for exploring the genetic mechanisms of sheep adaptation to extremely cold and arid environments.
Performance analysis of coalesce private or spill shared (CPOSS) replacement strategy overLRU to handle directory entry evictions from the slice last level cache (LLC) using a scalable coherent sparse directory in Multicore processor
Authors: Sahu Narottam , Dash Banchhanidhi , Al-Absi Ahmed Abdulhakim , Pattnaik Prasant Kumar 
Published: May 2024

Abstract

Ideally, we could solve all memory performance problems by storing everything in high performance caches. However, the associated high-cost forces us to keep only a limited amount of working sets of data in these caches and the replacement of disposable blocks of data with the desired one is a fundamental property to caches. Ultimately, the performance of a cache is heavily influenced by the replacement policy it uses. In this paper, we conduct a comparative analysis of a few replacement policies currently in use from traditional strategies to the ones that attempt to emulate optimal replacement and simulate a few replacement strategies to test the performance of multilevel cache by configuring the cache memory subsystem in the Multi2sim simulator. We have focused on the shared nature of the last Level Cache (LLC) which includes many coherence problems. This is where directories and coherence protocols come into play. However, the blocks suffer when the directory entries are themselves evicted from the directory. In this paper, we look into a cache coherence mechanism that instead of evicting the block from the private caches when the directory entry is evicted, rather than storing the entry in the LLC slice. This guarantees freedom from the Directory Eviction Victim Blocks (DEVB). We analyze the performance of our proposed replacement technique, namely, coalesce private or spill shared (CPOSS) by varying the size and associativity of the sparse directory by providing the workload from Parsec, Splash2 and FFTW benchmarks and we observe that the CPOSS outperforms the existing least recently used (LRU) in slice LLC banks in Multicore processors.