bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital leadership and innovative work behavior: impact of LMX, learning orientation and innovation capabilities
Authors: Ahmed Farooq , Naqshbandi M. Muzamil , Waheed Mehwish , Ain Noor ul 
Published: May 2024

PurposeGrounded in the Social Exchange theory, this study focuses on the perception of digital leadership and innovative work behaviors. It also examines the complex effects of leader-member exchange, learning orientation, and innovation capabilities.Design/methodology/approachWe undertake a quantitative approach using a two-wave longitudinal field survey of 440 employees and managers from various backgrounds working in the automobile industry in France.FindingsThe findings based on Structural Equation Modeling reveal that the perception of digital leadership leads to innovative work behavior while leader-member exchange moderates between the perception of digital leadership and learning orientation. The findings also support the mediating roles of learning orientation and innovation capabilities.Originality/valueThe study contributes important policy suggestions, raises queries for additional investigation, and suggests theoretical and practical implications for leadership and organizational environmental factors to foster innovative work behaviors in organizations.
Enhancing infrastructure project delivery through lean construction: opportunities, challenges and implementation strategies
Authors: Moshood Taofeeq Durojaye , Rotimi James O.B. , Shahzad Wajiha , Salimon Maruf Gbadebo 
Published: May 2024

PurposeOver the past two decades, the construction sector has experienced a surge in projects fueled by substantial government investment in infrastructure. However, amid this growth, the industry grapples with persistent challenges. Meeting project deadlines and budgets remains a struggle, impacting the industry’s credibility. Therefore, this research intends to investigate the idea of lean construction in the construction sector and look at the obstacles facing the construction industry in implementing lean construction strategies.Design/methodology/approachThe insights presented here result from content analysis performed on 206 articles, while the metadata analysis is based on 891 publications.FindingsThis study highlights numerous important characteristics that influence an organization’s capacity to accomplish lean construction using a systematic literature review approach.Research limitations/implicationsFor forthcoming research seeking validation, utilizing a mixed-method approach could prove advantageous. Yet, it is crucial to recognize the constraints of the present study, primarily centered on the scope of the literature review.Practical implicationsThis assessment will enhance comprehension of the lean construction concept, potentially encouraging the adopting of lean construction practices. Moreover, it could provide insights into effectively applying these methods in practice.Originality/valueThe literature review highlights the necessity for organizations to identify and address potential challenges they might encounter in implementing lean construction. An essential step in overcoming these obstacles involves exploring the concept of lean construction within the sector and assessing the hurdles constraining the implementation of lean construction strategies in the construction industry.
Commentary on: an evaluation of a speech and language therapy eating, drinking, and swallowing service for adults with intellectual disability (Crocker et al., 2024)
Authors: Stewart Kitty , Heckelmann Nina , Roos Alida 
Published: May 2024

Purpose
The purpose of this paper is to expand upon some of the issues raised in “An evaluation of a speech and language therapy eating, drinking and swallowing service for adults with intellectual disability” (Crocker et al., 2024).

Design/methodology/approach
This commentary outlines considerations for multidisciplinary team working and professional roles both within and beyond the community learning disability team. It discusses models of service delivery and competency frameworks relating to eating, drinking and swallowing services.

Findings
Services should be integrated, include a broad multidisciplinary team and aim to increase competency in all contexts supporting people with eating, drinking and swallowing needs. Outcomes of service provision need to be measured outside of individualised care.

Originality/value
This paper broadens the discussion of quality of eating, drinking and swallowing services beyond speech and language therapy and considers a whole systems approach.
Risk factors associated with Rohingya refugee girls' education in Bangladesh: A multilevel analysis of survey data
Authors: Hossain Mobarak 
Published: May 2024

AbstractIn Bangladesh, the world's largest refugee settlement currently shelters approximately one million Rohingya refugees who fled Myanmar to escape military persecution. Educating a significant number of young Rohingya, roughly half of whom are female, presents a significant challenge. Despite the presence of learning centres (LCs) across refugee camps, Rohingya girls may encounter specific barriers to accessing education due to exposure to various risks, such as violence, child marriage, and trauma stemming from past military oppression. This paper investigates the association between these risk factors and Rohingya girls' likelihood of attending LCs, and how this association may vary across refugee camps. Using survey data and employing three‐level multilevel logistic regression models, I find that girls are less likely to attend LCs if they are at risk of encountering sexual abuse, child marriage, and psychological distress or trauma. These factors explain considerable variation in girls' LC attendance between camps and between households. In addition to providing more schooling opportunities to Rohingya children, prioritising girls' safety, protecting them from forced and child marriage, and supporting their psychological well‐being require increased policy attention.
In utero aspirin exposure and child neurocognitive development: A propensity score‐matched analysis
Authors: Zhu Jing , Gan Yuexin , Yang Cuiping , Gu Wei , Wang Yanlin , Zhang Jun , Liu Zhiwei 
Published: May 2024

AbstractObjectiveTo evaluate the association between a short‐period, high‐dose in utero aspirin exposure and child neurocognitive development.DesignA propensity score‐matched analysis of a multicentre prospective cohort study.SettingThe US Collaborative Perinatal Project (1959–1976).PopulationA total of 50 565 singleton live births with maternal information.MethodsWe performed a propensity score matching to balance maternal characteristics between women with and without aspirin exposure. Inverse probability‐weighted marginal structural models were used to estimate associations between aspirin exposure and child neurocognitive assessments.Main outcome measuresChild neurocognitive development was assessed using the Bayley Scales at 8 months, the Stanford Binet Intelligence Scale at 4 years, and the Wechsler Intelligence Scale and Wide‐Range Achievement Test (WRAT) at 7 years.ResultsChildren exposed to aspirin in utero were associated with an 8%–16% reduced risk of having suspect/abnormal or below‐average scores in most neurocognitive assessments. A trend of lower risks of having suspect/abnormal or below‐average scores was further observed in children with in utero aspirin exposure for more than 7 days, particularly on Bayley Mental (relative risk [RR] 0.82, 95% CI 0.74–0.92), WRAT Reading (RR 0.88, 95% CI 0.78–0.98) and WRAT Arithmetic tests (RR 0.76, 95% CI 0.66–0.86). This association was mainly observed in the second trimester of pregnancy.ConclusionsIn utero aspirin exposure was associated with improved child neurocognitive development in a prospective cohort study. Further studies are warranted to evaluate the impact of long‐period and low‐dose in utero aspirin exposure on child short‐ and long‐term neurodevelopment.
‘Vitamin B17’: Killing more than cancer
Authors: Berling Ingrid , Brown Jared , Toy Brendan 
Published: May 2024

AbstractObjectiveVitamin B17 tablets are sold (online) as an alternative cancer therapy medication. Its use however is not benign, given that it is metabolised into hydrogen cyanide. We aimed to measure the number of calls received by the New South Wales Poisons Information Centre (NSW PIC) regarding Amygdalin exposures.MethodsA retrospective review of all amygdalin/cyanogenic glycoside product ingestion exposure calls to NSW PIC between 2015 and 2022.ResultsThere were 120 unique exposure calls. Eighty‐two (68%) were regarding minor exposures, with the remaining 38 (32%) of calls involving patients who had either a signifcant history or symptoms to prompt referral to hospital or were already seeking advice from a treating hospital clinican.ConclusionThere is a significant burden of concern generated from the misuse of cyanogenic glycoside products for cancer prevention and treatment, which can result in hospital admission carrying significant health risk and expenditure.
Firm‐level political risk and bank loan contracting
Authors: Saffar Walid , Wang Yang , Wei K. C. John 
Published: May 2024

AbstractWe investigate the impact of firm‐level political risk on loan contracting. We find that firm‐level political risk is positively associated with bank loan cost and that this effect is stronger for firms experiencing increased operational uncertainty and higher default risks. Firm‐level political risk also leads to more unfavorable non‐pricing loan terms. To alleviate endogeneity concerns, we use an instrumental variable approach and placebo tests. We further find that political connections and relationship‐based borrowing can attenuate the adverse effect of firm‐level political risk on loan contracting.
A new robust covariance matrix estimation for high‐dimensional microbiome data
Authors: Wang Jiyang , Liang Wanfeng , Li Lijie , Wu Yue , Ma Xiaoyan 
Published: May 2024

SummaryMicrobiome data typically lie in a high‐dimensional simplex. One of the key questions in metagenomic analysis is to exploit the covariance structure for this kind of data. In this paper, a framework called approximate‐estimate‐threshold (AET) is developed for the robust basis covariance estimation for high‐dimensional microbiome data. To be specific, we first construct a proxy matrix , which is almost indistinguishable from the real basis covariance matrix . Then, any estimator satisfying some conditions can be used to estimate . Finally, we impose a thresholding step on to obtain the final estimator . In particular, this paper applies a Huber‐type estimator , and achieves robustness by only requiring the boundedness of 2+ moments for some . We derive the convergence rate of under the spectral norm, and provide theoretical guarantees on support recovery. Extensive simulations and a real example are used to illustrate the empirical performance of our method.
Early ophthalmic growth deficits in preterm‐born children are not compensated for during later development
Authors: Fledelius Hans C. 
Published: May 2024

AbstractThe renewed focus on eye growth in preterm‐born children was primarily triggered by Danish cohort studies, including the Copenhagen Project, which focused on children born from 1959–1961. The retinotoxic effects of excessive oxygen on premature neonates had long been clarified and therapeutically adjusted for. Later, ultrasound oculometry and keratometry established that ocular size deficits, linked to development, also occurred in normally developing children, not just frail outliers. This indicated that general catch‐up had not been achieved. This paper discusses whether one early segment of eye development does not occur in preterm, and here even in more robust neonates, without later compensation.
Socio‐economic association of alcohol use disorder and cardiovascular and alcohol‐associated liver disease from 2010 to 2019
Authors: Danpanichkul Pojsakorn , Chen Vincent L. , Chaiyakunapruk Nathorn , Auttapracha Thanida , Kongarin Siwanart , Ng Cheng Han , Duangsonk Kwanjit , Muthiah Mark D. , Sukphutanan Banthoon , Sim Benedix , Huang Daniel Q. , Seko Yuya , Lee Brian P. , Takahashi Hirokazu , Noureddin Mazen , Lazarus Jeffrey V. , Díaz Luis Antonio , Arab Juan Pablo , Mellinger Jessica Leigh , Liangpunsakul Suthat , Wijarnpreecha Karn 
Published: May 2024

SummaryBackgrounds and AimsAlcohol use leads to disabilities and deaths worldwide. It not only harms the liver but also causes alcohol use disorder (AUD) and heart disease. Additionally, alcohol consumption contributes to health disparities among different socio‐economic groups.MethodsWe estimated global and regional trends in the burden of AUD, liver disease, and cardiovascular disease from alcohol using the methodology of the Global Burden of Disease study.ResultsIn 2019, the highest disability‐adjusted life years rate per 100,000 population was due to AUD (207.31 [95% Uncertainty interval (UI) 163.71–261.66]), followed by alcohol‐associated liver disease (ALD) (133.31 [95% UI 112.68–156.17]). The prevalence rate decreased for AUD (APC [annual percentage change] −0.38%) and alcohol‐induced cardiomyopathy (APC −1.85%) but increased for ALD (APC 0.44%) and liver cancer (APC 0.53%). Although the mortality rate for liver cancer from alcohol increased (APC 0.30%), mortality rates from other diseases decreased. Between 2010 and 2019, the burden of alcohol‐associated complications increased in countries with low and low‐middle sociodemographic index (SDI), contributing more significantly to the global burden.ConclusionThe global burden of AUD, liver, and cardiovascular disease has been high and increasing over the past decade, particularly for liver complications. Lower SDI countries are contributing more to this global burden. There is a pressing need for effective strategies to address this escalating burden.
Is mechanical bowel preparation necessary to reduce surgical site infection following colon surgery? Protocol for a multicentre Canadian randomized controlled trial
Authors: Ghuman Amandeep , Schmocker Selina , Brar Mantaj S. , Kennedy Erin D. 
Published: May 2024

AbstractAimThere is significant practice variation with respect to the use of bowel preparation to reduce surgical site infection (SSI) following colon surgery. Although intravenous antibiotics + mechanical bowel preparation + oral antibiotics (IVA + MBP + OA) has been shown to be superior to IVA + MBP and IVA, there are insufficient high‐quality data from randomized controlled trails (RCTs) that directly compare these options. This is an important question, because if IVA + OA has similar effectiveness to IVA + MBP + OA, mechanical bowel preparation can be safely omitted, and the associated side effects avoided. The aim of this work is to compare rates of SSI following IVA + OA + MBP (MBP) versus IVA + OA (OA) for elective colon surgery.MethodThis is a multicentre, parallel, two‐arm, noninferiority RCT comparing IVA + OA + MBP versus IVA + OA. The primary outcome is the overall rate of SSI 30 days following surgery. Secondary outcomes are length of stay and 30‐day emergency room visit and readmission rates. The planned sample size is 1062 subjects with four participating high‐volume centres. Overall SSI rates 30 days following surgery between the treatment groups will be compared using a general linear model. Secondary outcomes will be analysed with linear regression for continuous outcomes, logistic regression for binary outcomes and modified Poisson regression for count data.ConclusionIt is expected that IVA + OA will work similarly to IVA + MBP + OA and that this work will provide definitive evidence showing that MBP is not necessary to reduce SSI. This is highly relevant to both patients and physicians as it will have the potential to significantly change practice and outcomes following colon surgery in Canada and beyond.
Effects of a perioperative educational pathway on ostomy self‐care, level of independence and need for visiting nurse services: a comparative observational cohort study
Authors: van Pelt Kirsten A. A. J. , van Loon Yu Ting , Schots Judith P. M. , Ketelaers Stijn H. J. , Zimmerman David D. E. , Nieuwenhuijzen Grard A. P. , Rutten Harm J. T. , Burger Jacobus W. A. , Bloemen Johanne G. 
Published: May 2024

AbstractAimMost new ostomy patients are not able to manage ostomy self‐care when they are discharged and rely on visiting nurse services for ostomy care. The aim of this study was to determine if a perioperative ostomy educational pathway increases the level of independence and decreases the need for visiting nurse services in new ostomy patients.MethodA prospective longitudinal study was conducted between July 2018 and February 2020. Patients who received a colostomy or ileostomy and were treated on the surgery ward were included. Patients who followed a perioperative ostomy educational pathway were compared to a historical control group. The primary outcome measure was the level of independence in ostomy care and the need for visiting nurse services.ResultsAfter discharge, 67.6% of patients in the intervention group (n = 244) were able to independently perform ostomy care and were therefore not relying on visiting nurse services, compared to 15.2% of the patients in the control group (n = 33). The need for visiting nurse services was higher in patients aged ≥70 years (OR 3.20, P < 0.001), those who did not attend the preoperative practice session (OR 3.02, P = 0.002), those with a history of transient ischaemic attack (OR 10.22, P = 0.045) and those with mild cognitive impairment (OR 28.98, P = 0.002).ConclusionA perioperative ostomy educational pathway effectively increased the level of independence and decreased the need for visiting nurse services in new ostomy patients.
Population pharmacokinetics and CD20 binding dynamics for mosunetuzumab in relapsed/refractory B‐cell non‐Hodgkin lymphoma
Authors: Bender Brendan , Li Chi‐Chung , Marchand Mathilde , Turner David C. , Li Feifei , Vadhavkar Shweta , Wang Bei , Deng Rong , Lu James , Jin Jin , Li Chunze , Yin Shen , Wei Michael , Chanu Pascal 
Published: May 2024

AbstractMosunetuzumab (Mosun) is a CD20xCD3 T‐cell engaging bispecific antibody that redirects T cells to eliminate malignant B cells. The approved step‐up dose regimen of 1/2/60/30 mg IV is designed to mitigate cytokine release syndrome (CRS) and maximize efficacy in early cycles. A population pharmacokinetic (popPK) model was developed from 439 patients with relapsed/refractory B‐Cell Non‐Hodgkin lymphoma receiving Mosun IV monotherapy, including fixed dosing (0.05–2.8 mg IV every 3 weeks (q3w)) and Cycle 1 step‐up dosing groups (0.4/1/2.8–1/2/60/30 mg IV q3w). Prior to Mosun treatment, ~50% of patients had residual levels of anti‐CD20 drugs (e.g., rituximab or obinutuzumab) from prior treatment. CD20 receptor binding dynamics and rituximab/obinutuzumab PK were incorporated into the model to calculate the Mosun CD20 receptor occupancy percentage (RO%) over time. A two‐compartment model with time‐dependent clearance (CL) best described the data. The typical patient had an initial CL of 1.08 L/day, transitioning to a steady‐state CL of 0.584 L/day. Statistically relevant covariates on PK parameters included body weight, albumin, sex, tumor burden, and baseline anti‐CD20 drug concentration; no covariate was found to have a clinically relevant impact on exposure at the approved dose. Mosun CD20 RO% was highly variable, attributed to the large variability in residual baseline anti‐CD20 drug concentration (median = 10 μg/mL). The 60 mg loading doses increased Mosun CD20 RO% in Cycle 1, providing efficacious exposures in the presence of the competing anti‐CD20 drugs. PopPK model simulations, investigating Mosun dose delays, informed treatment resumption protocols to ensure CRS mitigation.
Associations of cold‐inducible RNA‐binding protein with bacterial load, proinflammatory cytokines and mortality from pneumonia
Authors: Guo Qi , Li Hai‐yan , Zeng Chao , Lü Zhong‐dong , Jiang Mei 
Published: May 2024

AbstractCold‐inducible RNA‐binding protein (CIRP) is a damage‐associated molecular pattern that plays a critical role in triggering inflammatory responses. It remains unknown whether CIRP is strongly associated with bacterial load, inflammatory response, and mortality in sepsis model. Pneumonia was induced in specific pathogen‐free 8–9‐week old male rats by injecting bacteria via puncture of the tracheal cartilage. The expressions of CIRP and proinflammatory cytokines [tumor necrosis factor‐α (TNF‐α), interleukin‐6 (IL‐6) and IL‐1β] in lung tissues, alveolar macrophages (AMs), plasma, and bronchoalveolar lavage fluid (BALF) were determined by reverse transcription‐polymerase chain reaction, western blotting, and enzyme‐linked immunosorbent assay. The numbers of bacteria recovered from the lungs were correlated with the bacterial loads injected and mortality. The expressions of CIRP increased sharply as the bacterial loads increased in the lung tissues and AMs. The amounts of TNF‐α, IL‐6 and IL‐1β proteins synthesized were dependent on the bacterial load in the lung tissues. Releases of CIRP, TNF‐α, IL‐6, and IL‐1β increased with the bacterial load in the blood plasma. The proteins confirmed similar patterns in the BALF. CIRP was strongly associated with the releases of TNF‐α, IL‐6, and IL‐1β in the lung tissues, blood plasma, and BALF, and showed a close correlation with mortality. CIRP demonstrated a strong association with bacterial load, which is new evidence, and close correlations with proinflammatory cytokines and mortality of pneumonia in rats, suggesting that it might be an interesting pneumonic biomarker for monitoring host response and predicting mortality, and a promising target for immunotherapy.
Nuclear long diameter as a new criterion to distinguish high‐grade urothelial carcinoma cells from benign reactive cells
Authors: Sakumo Kazuma , Tamura Juri , Nakamura Akihiro , Nukaya Takuhisa , Sofue Tadashi , Haba Reiji , Itoh Tomoo , Kamoshida Shingo , Ohsaki Hiroyuki 
Published: May 2024

AbstractObjectiveRecently, the nuclear area has attracted attention as a morphological parameter to differentiate high‐grade urothelial carcinoma (HGUC) cells from benign reactive cells. The nuclear long diameter (NLD) strongly correlates with the nuclear area and is easy to subjectively estimate. Therefore, this study examined the usefulness of the NLD‐to‐neutrophil diameter ratio for detecting HGUC cells in urine cytology.MethodsThis study included 29, 26 and 18 patients with HGUC, glomerular disease and urolithiasis respectively. An image analysis system was used to measure the NLD of HGUC and benign reactive cells (reactive renal tubular cells and reactive urothelial cells) and the neutrophil diameter that appeared in the voided urine in these cases. The NLD index was calculated using the NLD‐to‐neutrophil diameter ratio. We subsequently compared HGUC and benign reactive cells with respect to NLD and NLD indices. In addition, the HGUC cell group and benign reactive cell group were compared by selecting the five cells with the largest NLD and NLD index on each slide.ResultsThe NLD and NLD indices of HGUC cells were significantly higher than those of benign reactive cells in all cells and in the five cells with the largest NLD and NLD indices. The cut‐off value of the NLD index for detecting HGUC cells was 1.25 in all cells and 1.80 in the five cells with the largest NLD index.ConclusionsThe NLD index is a useful parameter that can be introduced into routine microscopic examinations to differentiate HGUC cells from benign reactive cells.