bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of virtual reality OSCE on nursing students’ education: a study protocol for systematic review and meta-analysis
Authors: Liu Ping , Dong Xuan , Liu Fei , Fu Haixia 
Published: May 2024

IntroductionVirtual objective structured clinical examination (OSCE) has been shown to influence the performance of nursing students. However, its specific effects, particularly students’ competence, stress, anxiety, confidence, satisfaction with virtual reality OSCE and examiners’ satisfaction, remain unclear.Method and analysisThis study aims to assess the effects of virtual reality OSCE on nursing students’ education. The study follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol guidelines. A literature search is performed on electronic databases, namely, PubMed, Web of Science, CINAHL, EBSCO, EMBASE and the Cochrane Library. The inclusion criteria adhere to the PICOS principle, encompassing nursing students, including those studying in school and those engaged in hospital internship. This review includes studies on the use of virtual reality OSCE as an assessment tool, compared with traditional clinical examinations, such as in-person OSCE. The outcome assessments encompass (1) competence, (2) stress, (3) anxiety, (4) confidence, (5) student satisfaction with virtual reality OSCE and (6) examiners’ satisfaction. These studies are designed as randomised controlled trials (RCTs) or quasi-experimental research. The search time is from the inception of each database to 30 June 2023, without language restriction. Studies for inclusion are screened by two reviewers for data extraction dependently. Any dispute is resolved through discussion. Unresolved disputes are decided by consulting a third author. For the risk of bias (ROB) assessment, the Cochrane ROB tool for RCTs and the risk of bias in non-randomised studies of intervention tool are used. Moreover, RevMan V.5.3 is used for meta-analysis.Ethics and disseminationThis study protocol does not include any clinical research and thus does not require ethical approval. Research findings are published in a peer-reviewed journal.PROSPERO registration numberCRD42023437685.
Pulmonary rehabilitation in Iranian outpatients with mustard gas lung disease: a randomised controlled trial
Authors: Ghanei Mostafa , Philip Keir E J , Moghadam Mohamed R S , Hosseini Hamed , Babaie Aliakbar , Roustanezhad Mohammad , Hopkinson Nicholas S 
Published: May 2024

ObjectivePeople with mustard gas lung disease experience cough, sputum, breathlessness and exercise limitation. We hypothesised that pulmonary rehabilitation (PR) would be beneficial in this condition.DesignAn assessor-blind, two-armed, parallel-design randomised controlled clinical trial.SettingSecondary care clinics in Iran.Participants60 men with breathlessness due to respiratory disease caused by documented mustard gas exposure, mean (SD) age 52.7 (4.36) years, MRC dyspnoea score 3.5 (0.7), St. George’s Respiratory Questionnaire (SGRQ) 72.3 (15.2).InterventionsParticipants were allocated either to a 6-week course of thrice-weekly PR (n=31) or to usual care (n=29), with 6-week data for 28 and 26, respectively.Outcome measuresPrimary endpoint was change in cycle endurance time at 70% baseline exercise capacity at 6 weeks. Secondary endpoints included 6 min walk distance, quadriceps strength and bulk, body composition and health status. For logistical reasons, blood tests that had been originally planned were not performed and 12-month follow-up was available for only a small proportion.ResultsAt 6 weeks, cycle endurance time increased from 377 (140) s to 787 (343) s with PR vs 495 (171) s to 479 (159) s for usual care, effect size +383 (231) s (p<0.001). PR also improved 6 min walk distance+103.2 m (63.6–142.9) (p<0.001), MRC dyspnoea score −0.36 (−0.65 to −0.07) (p=0.016) and quality of life; SGRQ −8.43 (−13.38 to −3.48) p<0.001, as well as quadriceps strength+9.28 Nm (1.89 to 16.66) p=0.015.ConclusionThese data suggest that PR can improve exercise capacity and quality of life in people with breathlessness due to mustard gas lung disease and support the wider provision of this form of care.Trial registration numberIRCT2016051127848N1.
Performance of generative pre-trained transformers (GPTs) in Certification Examination of the College of Family Physicians of Canada
Authors: Mousavi Mehdi , Shafiee Shabnam , Harley Jason M , Cheung Jackie Chi Kit , Abbasgholizadeh Rahimi Samira 
Published: May 2024

IntroductionThe application of large language models such as generative pre-trained transformers (GPTs) has been promising in medical education, and its performance has been tested for different medical exams. This study aims to assess the performance of GPTs in responding to a set of sample questions of short-answer management problems (SAMPs) from the certification exam of the College of Family Physicians of Canada (CFPC).MethodBetween August 8th and 25th, 2023, we used GPT-3.5 and GPT-4 in five rounds to answer a sample of 77 SAMPs questions from the CFPC website. Two independent certified family physician reviewers scored AI-generated responses twice: first, according to the CFPC answer key (ie, CFPC score), and second, based on their knowledge and other references (ie, Reviews’ score). An ordinal logistic generalised estimating equations (GEE) model was applied to analyse repeated measures across the five rounds.ResultAccording to the CFPC answer key, 607 (73.6%) lines of answers by GPT-3.5 and 691 (81%) by GPT-4 were deemed accurate. Reviewer’s scoring suggested that about 84% of the lines of answers provided by GPT-3.5 and 93% of GPT-4 were correct. The GEE analysis confirmed that over five rounds, the likelihood of achieving a higher CFPC Score Percentage for GPT-4 was 2.31 times more than GPT-3.5 (OR: 2.31; 95% CI: 1.53 to 3.47; p<0.001). Similarly, the Reviewers’ Score percentage for responses provided by GPT-4 over 5 rounds were 2.23 times more likely to exceed those of GPT-3.5 (OR: 2.23; 95% CI: 1.22 to 4.06; p=0.009). Running the GPTs after a one week interval, regeneration of the prompt or using or not using the prompt did not significantly change the CFPC score percentage.ConclusionIn our study, we used GPT-3.5 and GPT-4 to answer complex, open-ended sample questions of the CFPC exam and showed that more than 70% of the answers were accurate, and GPT-4 outperformed GPT-3.5 in responding to the questions. Large language models such as GPTs seem promising for assisting candidates of the CFPC exam by providing potential answers. However, their use for family medicine education and exam preparation needs further studies.
Influence of dietary mulberry leaf on the nutritional composition of mulberry silkworm, Bombyx mori L. at different developmental stages
Authors: Pongworn S. , Wongsa J. , Vatanyoopaisarn S. , Thumthanaruk B. , Uttapap D. , Lamsal B. , Rungsardthong V. 
Published: May 2024

Abstract
The distribution of mulberry leaf nutrients and trace elements into silkworm larvae over its development into pupa was investigated for potential novel food applications. Four stages of chronologically collected silkworm larvae, fed with mulberry leaves, were sampled. Proximate composition, vitamin A, β-carotene, mineral, fatty, and amino acid profiles were analyzed. The highest protein content was 63.68% in the fourth instar, whereas lipid was markedly highest at 31.85% in pupa. Magnesium and potassium were found to exceed the Thai recommended daily intake standard (RDI) in almost all stages, except for the potassium in the pupa. Vitamin A in the third to fifth instar was also found to be more than Thai RDI. The distinct highest zinc and fatty acid content were detected in the pupa. Monounsaturated fatty acids were detected at the highest levels in all stages. Sulfur-containing amino acids were abundant in the fifth instar. The fourth instar, the fifth instar, and the pupa are recommended as sources of protein, amino acids, fatty acids, and lipids in developing suitable food products.
The Role of Temperature and Rainfall in Traffic Congestion: Evidence from 98 Chinese Cities
Authors: Wu Jingwen , Zhang Chen 
Published: May 2024

Abstract
Improving the performance and resilience of the transportation system in cities is an important way to combat climate change. However, the relationship between weather conditions and traffic congestion remains unclear. This study investigates the association between weather conditions and traffic congestion [congestion delay index (CDI)] using a dataset encompassing 98 cities in China from 2015 to 2019. The results reveal that temperature exerts a significant negative effect on CDI, particularly during weekends. Conversely, rain, wind speed, and relative humidity exhibit significant positive effects on CDI. Specifically, traffic congestion would decrease by 6% when the temperature exceeds 25°C, while it increases by 2%–5.6% with rainfall increases on workdays. Besides, the precipitation–CDI relationship shows an inverse U shape, especially on weekends. Although subways could mitigate the impact of temperature on cities compared to those without subways, the supplementary effect is mild on rainy days.

Significance Statement
The increasing frequency of extreme weather events poses great threats to cities’ transport systems, and understanding the association between weather conditions and traffic congestion is insightful for future transport planning. The results show that traffic congestion would decrease by 6% when the temperature exceeds 25°C, while it increases by 2%–5.6% with rainfall increases on workdays and the association becomes nonlinear on weekends. Besides, cities equipped with subway systems demonstrate greater resilience to hot weather conditions, although rainfall’s impact remains challenging to mitigate.
A SARS-CoV-2 minimum data standard to support national serology reporting
Authors: Urwin Esmond , Martin Joanne , Sebire Neil , Harris Andy , Johnson Jenny , Masood Erum , Milligan Gordon , Mairs Lucy , Chuter Antony , Ferguson Michael , Quinlan Philip , Jefferson Emily 
Published: May 2024

Background Healthcare laboratory systems produce and capture a vast array of information, yet do not always report all of this to the national infrastructure within the United Kingdom. The global COVID-19 pandemic brought about a much greater need for detailed healthcare data, one such instance being laboratory testing data. The reporting of qualitative laboratory test results (e.g. positive, negative or indeterminate) provides a basic understanding of levels of seropositivity. However, to better understand and interpret seropositivity, how it is determined and other factors that affect its calculation (i.e. levels of antibodies), quantitative laboratory test data are needed. Method 36 data attributes were collected from 3 NHS laboratories and 29 CO-CONNECT project partner organisations. These were assessed against the need for a minimum dataset to determine data attribute importance. An NHS laboratory feasibility study was undertaken to assess the minimum data standard, together with a literature review of national and international data standards and healthcare reports. Results A COVID serology minimum data standard (CSMDS) comprising 12 data attributes was created and verified by 3 NHS laboratories to allow national granular reporting of COVID serology results. To support this, a standardised set of vocabulary terms was developed to represent laboratory analyser systems and laboratory information management systems. Conclusions This paper puts forward a minimum viable standard for COVID-19 serology data attributes to enhance its granularity and augment the national reporting of COVID-19 serology laboratory results, with implications for future pandemics.
The Launch of Massachusetts Community Health Worker Certification: Findings From the Massachusetts Community Health Worker Workforce Surveys
Authors: Nielsen Victoria M. , Ursprung W.W. Sanouri , Song Glory , Hirsch Gail , Mason Theresa , Santarelli Claire , Guimaraes Erica , Marshall Erica , Allen Caitlin G. , Lei Pei-Pei , Brown Diane , Behl-Chadha Bittie 
Published: May 2024

Objectives: The launch of state certification for community health workers (CHWs) in Massachusetts in 2018 aimed to promote and champion this critical workforce. However, concerns exist about unintentional adverse effects of certification. Given this, we conducted 2 cross-sectional surveys to evaluate this certification policy. Methods: We conducted surveys of CHW employers and CHWs in 3 sample frames: community health centers and federally qualified health centers, acute-care hospitals, and community-based organizations. We administered the surveys in 2016 (before certification launch) and 2021 (after certification launch) to answer the following questions: Was certification associated with positive outcomes among CHWs after its launch? Did harmful shifts occur among the CHW workforce and employers after certification launch? Was certification associated with disparities among CHWs after its launch? Results: Certification was associated with higher pay among certified (vs noncertified) CHWs, better perceptions of CHWs among certified (vs noncertified) CHWs, and better integration of certified (vs noncertified) CHWs into care teams. We found no adverse shifts in CHW workforce by sociodemographic variables or in CHW employer characteristics (most notably CHW employer hiring requirements) after certification launch. After certification launch, certified and uncertified CHWs had similar demographic and educational characteristics. However, certified CHWs more often worked in large, clinical organizations while uncertified CHWs most often worked in medium-sized community-based organizations. Conclusions: Our evaluation of Massachusetts CHW certification suggests that CHW certification was not associated with workforce disparities and was associated with positive outcomes. Our study fills a notable gap in the research literature and can guide CHW research agendas, certification efforts in Massachusetts and other states, and program efforts to champion this critical, grassroots workforce.
Evaluation of the effect of enriched hydrogen saline solution on distant organ (lung) damage in skeletal muscle ischemia reperfusion in rats
Authors: Özer Abdullah , Erel Selin , Küçük Ayşegül , Demirtaş Hüseyin , Sezen Şaban Cem , Boyunağa Hakan , Oktar Gürsel Levent , Arslan Mustafa 
Published: May 2024

Introduction Ischemia-reperfusion (IR) injury is a major concern that frequently occurs during vascular surgeries. Hydrogen-rich saline (HRS) solution exhibits antioxidant and anti-inflammatory properties. This study aimed to examine the effects of HRS applied before ischemia in the lungs of rats using a lower extremity IR model. Material and Methods After approval was obtained from the ethics committee, 18 male Wistar albino rats weighing 250–280 g were randomly divided into three groups: control (C), IR and IR-HRS. In the IR and IR-HRS groups, an atraumatic microvascular clamp was used to clamp the infrarenal abdominal aorta, and skeletal muscle ischemia was induced. After 120 min, the clamp was removed, and reperfusion was achieved for 120 min. In the IR-HRS group, HRS was administered intraperitoneally 30 min before the procedure. Lung tissue samples were examined under a light microscope and stained with hematoxylin-eosin (H&E). Malondialdehyde (MDA) levels, total sulfhydryl (SH) levels, and histopathological parameters were evaluated in the tissue samples. Results MDA and total SH levels were significantly higher in the IR group than in the control group ( p < 0.0001 and p = 0.001, respectively). MDA and total SH levels were significantly lower in the IR-HRS group than in the IR group ( p < 0.0001 and p = 0.013, respectively). A histopathological examination revealed that neutrophil infiltration/aggregation, alveolar wall thickness, and total lung injury score were significantly higher in the IR group than in the control group ( p < 0.0001, p = 0.001, and p < 0.0001, respectively). Similarly, alveolar wall thickness and total lung injury scores were significantly higher in the IR-HRS group than in the control group ( p = 0.009 and p = 0.004, respectively). A statistically significant decrease was observed in neutrophil infiltration/aggregation and total lung injury scores in the IR-HRS group compared to those in the IR group ( p = 0.023 and p = 0.022, respectively). Conclusion HRS at a dose of 20 mg/kg, administered intraperitoneally 30 min before ischemia in rats, reduced lipid peroxidation and oxidative stress, while also reducing IR damage in lung histopathology. We believe that HRS administered to rats prior to IR exerts a lung-protective effect.
Building Breastfeeding Research Relations and Beyond: An Interview With Fiona Dykes
Authors: Cassidy Tanya M. , Dykes Fiona 
Published: May 2024

Professor Fiona Dykes is Professor Emerita of Maternal and Infant Health at the University of Central Lancashire in the United Kingdom (UCLAN). Fiona has a particular interest in the global, sociocultural, and political influences upon infant and young child feeding practices; her methodological expertise is in ethnography and other qualitative research methods. She founded the Maternal and Infant Nutrition and Nurture Unit (MAINN) in 2000 which she led until she retired from her full-time professorship in 2020. Fiona established the associated MAINN Conference in 2007. The MAINN conference is a 3 day, international, peer reviewed event held bi-annually in the United Kingdom and, more recently, in alternate years overseas (Sydney, Australia; Falun, Dalarna, Sweden; and Florida, United States). The conference draws together key researchers in the field of infant and young child feeding from around the world. Fiona was a founding member of the journal Maternal and Child Nutrition. She is author of Breastfeeding in Hospital: Mothers, Midwives and the Production Line (Routledge) and co-author, with Dr Tanya Cassidy, of Banking on Milk: An Ethnography of Donor Human Milk Relations (Routledge). She is also joint editor of several books including Infant and Young Child Feeding: Challenges to Implementing a Global Strategy (Wiley-Blackwell) and Ethnographic Research in Maternal and Child Health (Routledge). This interview was conducted on April 20, 2023, by Dr. Tanya Cassidy, and is based on a verbatim transcription and edited for readability. TC = Tanya Cassidy; FD = Fiona Dykes
Trichotillomania: A perspective from bibliometric analysis
Authors: Ertürk Emre , Aktepe Evrim , Eroğlu Doğan Havvanur 
Published: May 2024

Aim: Trichotillomania, an obsessive-compulsive-related disorder, is defined by the recurrent act of pulling out one’s own hair from different areas of the body. Despite the considerable body of research dedicated to the subject of trichotillomania, the overarching trends that unify these studies remain obscure. The purpose of the present bibliometric analysis was to ascertain these trends. Method: To achieve this objective, we conducted a thorough search of publications in the Web of Science database and subsequently evaluated the acquired data using VOSviewer software. Results: The most cited article on trichotillomania was written by Simonoff et al. The most prolific writer on trichotillomania is Grant JE. The most publications on the subject of trichotillomania were published in the “Journal of Obsessive Compulsive and Related Disorders” and the most frequently repeated keyword is trichotillomania. Trichotillomania studies have focused on treatment, clinical features, and other accompanying psychiatric conditions. Conclusion: Potential areas of research could include treatment methods in addition to the psychiatric and physical comorbidities of trichotillomania, and efforts to enhance international collaborations in this domain should be intensified.
Ophthalmologists’ awareness of geographic atrophy: An Italian survey including 365 participants
Authors: Arrigo Alessandro , Aragona Emanuela , Allamprese Michele , Battaglia Parodi Maurizio 
Published: May 2024

Purpose Geographic atrophy (GA) is a severe complication of age-related macular degeneration (AMD) and leads to irreversible visual decline. To date, no effective treatment is available for GA patients. However, a number of new therapies have recently been approved and several others are in the pipeline. This rapid evolution of prospects for GA patients requires constant updating of ophthalmologists’ understanding of GA and its management so as to provide the appropriate treatment. For this reason, Società Italiana di Scienze Oftalmologiche (S.I.S.O.) has designed a specific survey to gauge the position of Italian ophthalmologists in this regard. Methods The three hundred and sixty-five Italian ophthalmologists who agreed to take part received a seventeen-part questionnaire guaranteeing privacy and anonymity. The survey was compiled through an online portal and the results were sent directly to S.I.S.O. ETS. Two graders analyzed the data and recorded the results. Results The results showed a high level of self-assessed awareness and understanding of GA, as well as considerable willingness to further improve knowledge of the disease. Most of the participants claimed to have effective rules of conduct in place for managing GA patients, including prompt response, involving a high prevalence of nutraceutical prescriptions and lifestyle recommendations. Conclusions This survey provided an overview of how GA patients are managed in Italy. The Italian ophthalmology community appears to be ready to adopt the upcoming treatments for GA.
Efficacy of Treatments in Reducing Inflammatory Lesion Count in Rosacea: A Systematic Review
Authors: Geng Ryan S. Q. , Sood Siddhartha , Hua Nicholas , Chen Jennifer , Sibbald Ronald G. , Sibbald Cathryn 
Published: May 2024

Introduction: Rosacea is a chronic inflammatory skin condition affecting approximately 5.5% of the global population. Patients present heterogeneously with a mix of features in the central facial region, of which papules and pustules are considered to be a major feature. The identification of effective treatments for reducing inflammatory lesions in rosacea can alleviate the psychosocial burden that many rosacea patients experience, including reduced self-esteem, anxiety, and social withdrawal. The objective of this systematic review is to determine the effectiveness of topical and systemic therapies in reducing lesion count in rosacea patients. Methods/Results: Medline, Embase, and Cochrane CENTRAL databases were searched, resulting in the inclusion of 43 clinical trials reporting on a total of 18,347 rosacea patients. The most well-studied treatments include ivermectin, metronidazole, azelaic acid, minocycline, and doxycycline. Oral isotretinoin was the most effective treatment in reducing inflammatory lesions and may be recommended for severe recalcitrant cases of rosacea. Conclusions: Several topical and systemic therapies have demonstrated efficacy in reducing inflammatory lesion count in rosacea patients, with mechanisms of action centred around suppressing inflammation and killing Demodex folliculorum mites. Additional research is required to determine effective combination therapies in rosacea.