bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing
Authors: Harries Lorna W. , Hernandez Dena , Henley William , Wood Andrew R. , Holly Alice C. , Bradley‐Smith Rachel M. , Yaghootkar Hanieh , Dutta Ambarish , Murray Anna , Frayling Timothy M. , Guralnik Jack M. , Bandinelli Stefania , Singleton Andrew , Ferrucci Luigi , Melzer David 
Published: June 2011

SummaryAging is a major risk factor for chronic disease in the human population, but there are little human data on gene expression alterations that accompany the process. We examined human peripheral blood leukocyte in‐vivo RNA in a large‐scale transcriptomic microarray study (subjects aged 30–104 years). We tested associations between probe expression intensity and advancing age (adjusting for confounding factors), initially in a discovery set (n = 458), following‐up findings in a replication set (n = 240). We confirmed expression of key results by real‐time PCR. Of 16 571 expressed probes, only 295 (2%) were robustly associated with age. Just six probes were required for a highly efficient model for distinguishing between young and old (area under the curve in replication set; 95%). The focused nature of age‐related gene expression may therefore provide potential biomarkers of aging. Similarly, only 7 of 1065 biological or metabolic pathways were age‐associated, in gene set enrichment analysis, notably including the processing of messenger RNAs (mRNAs); [P < 0.002, false discovery rate (FDR) q < 0.05]. This is supported by our observation of age‐associated disruption to the balance of alternatively expressed isoforms for selected genes, suggesting that modification of mRNA processing may be a feature of human aging.
Parent experiences of attending a specialist clinic for assessment of their child's obsessive compulsive disorder
Authors: Hilton Kristina , Turner Cynthia , Krebs Georgina , Volz Chloe , Heyman Isobel 
Published: June 2011

Background:  There are few published studies that have examined parental satisfaction with child mental health assessment. This study reports parental satisfaction with assessment in a national and specialist Child and Adolescent Mental Health Service for obsessive‐compulsive disorder (OCD) and related disorders.Method:  Forty parents completed a specially developed questionnaire designed to assess expectations and experiences of attending a specialist assessment.Results:  High levels of satisfaction were reported. Common expectations of the assessment included: advice or information about the treatment of OCD, a diagnosis or understanding of the child's problems, and an offer of treatment.Conclusions:  The majority of parents reported that their expectations were met, and some suggestions for improvement to the service were noted.
Applying a system approach to forecast the total hepatitis C virus‐infected population size: model validation using US data
Authors: Kershenobich David , Razavi Homie A. , Cooper Curtis L. , Alberti Alfredo , Dusheiko Geoffrey M. , Pol Stanislas , Zuckerman Eli , Koike Kazuhiko , Han Kwang‐Hyub , Wallace Carolyn M. , Zeuzem Stefan , Negro Francesco 
Published: June 2011

AbstractBackground: Hepatitis C virus (HCV) infection is associated with chronic progressive liver disease. Its global epidemiology is still not well ascertained and its impact will be confronted with a higher burden in the next decade.Aim: The goal of this study was to develop a tool that can be used to predict the future prevalence of the disease in different countries and, more importantly, to understand the cause and effect relationship between the key assumptions and future trends.Methods: A system approach was used to build a simulation model where each population was modeled with the appropriate inflows and outflows. Sensitivity analysis was used to identify the key drivers of future prevalence.Results: The total HCV‐infected population in the US was estimated to decline 24% from 3.15 million in 2005 to 2.47 million in 2021, while disease burden will increase as the remaining infected population ages. During the same period, the mortality rate was forecasted to increase from 2.1 to 3.1%. The diagnosed population was 50% of the total infections, while less than 2% of the total infections were treated.Conclusion: We have created a framework to evaluate the HCV‐infected populations in countries around the world. This model may help assess the impact of policies to meet the challenges predicted by the evolution of HCV infection and disease. This prediction tool may help to target new public health strategies.
A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel
Authors: Cornberg Markus , Razavi Homie A. , Alberti Alfredo , Bernasconi Enos , Buti Maria , Cooper Curtis , Dalgard Olav , Dillion John F. , Flisiak Robert , Forns Xavier , Frankova Sona , Goldis Adrian , Goulis Ioannis , Halota Waldemar , Hunyady Bela , Lagging Martin , Largen Angela , Makara Michael , Manolakopoulos Spilios , Marcellin Patrick , Marinho Rui T. , Pol Stanislas , Poynard Thierry , Puoti Massimo , Sagalova Olga , Sibbel Scott , Simon Krzysztof , Wallace Carolyn , Young Kendra , Yurdaydin Cihan , Zuckerman Eli , Negro Francesco , Zeuzem Stefan 
Published: June 2011

AbstractBackground and Aim: Decisions on public health issues are dependent on reliable epidemiological data. A comprehensive review of the literature was used to gather country‐specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel.Methodology: Data references were identified through indexed journals and non‐indexed sources. In this work, 13 000 articles were reviewed and 860 were selected based on their relevance.Results: Differences in prevalence were explained by local and regional variances in transmission routes or different public health measures. The lowest HCV prevalence (≤0.5%) estimates were from northern European countries and the highest (≥3%) were from Romania and rural areas in Greece, Italy and Russia. The main risk for HCV transmission in countries with well‐established HCV screening programmes and lower HCV prevalence was injection drug use, which was associated with younger age at the time of infection and a higher infection rate among males. In other regions, contaminated glass syringes and nosocomial infections continue to play an important role in new infections. Immigration from endemic countries was another factor impacting the total number of infections and the genotype distribution. Approximately 70% of cases in Israel, 37% in Germany and 33% in Switzerland were not born in the country. In summary, HCV epidemiology shows a high variability across Europe, Canada and Israel.Conclusion: Despite the eradication of transmission by blood products, HCV infection continues to be one of the leading blood‐borne infections in the region.
Hepatobiliary cystadenomas and cystadenocarcinomas: a report of 33 cases
Authors: Sang Xinting , Sun Yongliang , Mao Yilei , Yang Zhiying , Lu Xin , Yang Huayu , Xu Haifeng , Zhong Shouxian , Huang Jiefu 
Published: June 2011

Abstract
Background: Hepatobiliary cystadenomas and cystadenocarcinomas are rare and often misdiagnosed.
Aims: We report our experience with 33 cases over 20 years to discuss an algorithm for these diseases.
Methods: Patients presenting with a diagnosis of hepatobiliary cystadenomas and cystadenocarcinomas were retrospectively reviewed from January 1991 to October 2010. Clinical data were collected by examining hospital records and by follow‐up questionnaire interviews.
Results: Thirty‐three patients had pathologically diagnosed hepatobiliary cystadenomas (19/33, 17 females and two males) or cystadenocarcinomas (14/33, five females and nine males). Symptoms of cystadenomas at hospitalization were abdominal bloating or pain (9/19). Nine patients had an elevated level of carbohydrate antigen (CA) 19‐9. The surgical procedures, i.e. cyst enucleation, segmentectomy, sectionectomy and hemihepatectomy, were performed with satisfactory outcomes. Symptoms of cystadenocarcinomas included abdominal bloating or pain (8/14) and fever (3/14). Seven patients had elevated CA19‐9. The imaging characteristics of cystadenocarcinomas were similar to those of cystadenomas. The clinical outcomes for cystadenocarcinomas were mostly poor after either surgical or conservative treatment.
Conclusions: Clinical symptoms are unreliable for these diagnoses and their differential diagnosis. Imaging evaluations and CA19‐9 are of value for the recognition of cystadenoma and cystadenocarcinoma, but not for their differential diagnosis. Any recurrence of liver cyst after surgery or other treatments should lead one to suspect one of these diseases. Invasive examination and percutaneous fine‐needle aspiration cytology are not recommended. Complete excision or careful enucleation should be the first treatment choice for a better prognosis.
NOD2 gene variants are a risk factor for culture‐positive spontaneous bacterial peritonitis and monomicrobial bacterascites in cirrhosis
Authors: Bruns Tony , Peter Jack , Reuken Philipp A. , Grabe Dominik H. , Schuldes Sonja R. , Brenmoehl Julia , Schölmerich Jürgen , Wiest Reiner , Stallmach Andreas 
Published: June 2011

Abstract
Background: Spontaneous bacterial peritonitis (SBP) is considered as result of bacterial translocation from the gastrointestinal lumen to the mesenteric lymph nodes and subsequent circulation. Variants of the NOD2 gene contribute to bacterial translocation and were associated with SBP in a recent study.
Methods: We determined common NOD2 variants by TaqMan polymerase chain reaction and analysed the ascitic fluid neutrophil count and bacterial culture results in 175 prospectively characterized hospitalized patients with decompensated cirrhosis who underwent diagnostic paracentesis in two German centres.
Results: Ten patients presented with culture‐positive SBP, 19 with culture‐negative SBP and six had bacterascites. Minor allele frequencies for R702W, G908R and 1007fs in subjects with sterile non‐neutrocytic ascites were 3.2, 2.5 and 2.5% respectively. Patients with SBP [odds ratio (OR) 2.7; P=0.036], culture‐positive SBP (OR 6.0; P=0.012) and bacterascites (OR 6.0; P=0.050) were more often carriers of NOD2 variants than patients with sterile non‐neutrocytic ascites. The mutations 1007fs and G908R were associated with culture‐positive SBP (P≤0.005) and R702W with bacterascites (P=0.014). There was no significant association of NOD2 variants with culture‐negative SBP (OR 1.6; P=0.493). In logistic regression, previous SBP, a higher model for end‐stage liver disease (MELD) score and the presence of a NOD2 variant were independent predictors of ascitic fluid infection. The median survival was insignificantly shorter in patients with NOD2 variants (268 vs. 339 days; P=0.386). In patients without hepatocellular carcinoma at study entry (N=148), NOD2 was a predictor of survival after adjustment for the MELD score and age (hazard ratio 1.89; P=0.045).
Conclusion:
NOD2 variants increase the risk for culture‐positive SBP and bacterascites in cirrhosis and may affect survival.
Intrinsic Factors for Continued ERP Learning: A Precursor to Interdisciplinary ERP Curriculum Design
Authors: Chen Kuanchin , Razi Muhammad , Rienzo Thomas 
Published: June 2011

ABSTRACTUnilateral enterprise resource planning (ERP) curriculum improvements from the instructor's perspective are likely to generate only limited success. Understanding student motivations and beliefs with ERP systems is the missing link to effective ERP education. Relatively little attention in the ERP literature has been given to student learning associated with ERP experience, and almost none to factors influencing current and expected student beliefs and behaviors relative to ERP. The complexity of ERP systems demands that beliefs and behaviors be considered when planning ERP curricula. In the present study, the Theory of Planned Behavior was extended to examine students’ intentions to explore additional aspects of ERP after their class exercises. When considering all students, attitude and subjective norm had positive and significant effects on intentions to continue ERP learning. Subjective norm also affected attitude, and availability of support materials had a positive effect on subjective norm. Distinctive patterns are found for the construct relationships between student groups who valued ERP education (the engaged) and those who placed little or no value on ERP education (the undecided). Results from competing model analyses indicate that support materials influenced the engaged and undecided groups differently. Strategies for ERP curriculum design are provided.
Project Cheddarfield: Supporting Co‐Curricular Themes Through Creative Use of Video Course‐Casting
Authors: Simpson Natalie C. , Hancock Philip G. 
Published: June 2011

ABSTRACTThis article chronicles the coordination and better integration of existing institutional resources to support cocurricular themes embedded in the provision of a large enrollment, video‐mediated undergraduate operations management (OM) course. The name Project Cheddarfield refers to a 2008 initiative in which two professors team‐taught an OM course to over 600 undergraduates on two different continents through the repeated rapid exchange of digital video between the United States and Singapore. Simultaneously infused in this core curricular delivery were themes of global awareness and study‐abroad, including the promotion of one particular opportunity that bridged the two campuses. This action research narrative spans over 5 years of related activity leading up to the initiative, as this project is best understood as a trajectory, or the evolving result of design adapting to unfolding realities.
Knowledge Management ERP Curriculum Design/Mapping (Theory and Development Tools)
Authors: Swanson Zane , Hepner Michelle 
Published: June 2011

ABSTRACTThis study proposes a knowledge management framework for developing and managing enterprise resource planning (ERP) curriculum within business schools. Both theory and a practical implementation are addressed. The knowledge management (KM)1 framework has two components which utilize ERP from a big picture curriculum overview and a ground level coursework perspective. First, a flowchart illustrates the mapping of ERP2 system practice cases to program courses. Using the flowchart, faculty can more easily communicate and manage ERP curriculum features within an existing major course structure. Our design was implemented using a specific ERP system and example company setup to provide for minimal start‐up and overhead costs for faculty and a minimal learning curve for students. The second component of the KM framework provides a mapping and library function. Specific design course cells have a general description of case summary features and/or homework exercises. Each design course cell also links to the relevant ERP system settings and a list of learning objectives. This mapping enables one company to be used throughout an undergraduate Accounting or IS degree program where the student's learning experiences in each course are tailored to provide by program's end a broad experiential view of ERP system usage. The system design flowchart is flexible and can be modified year‐to‐year or differentiated to work at any school. The system design flowchart also enables faculty to assign a list of accreditation competencies (within the context of learning objectives) to each course in the system design chart.
The Ordering Challenge: An Online Game to Introduce Independent Demand Inventory Concepts
Authors: Meyer Brad C. , Bishop Debra S. 
Published: June 2011

ABSTRACTStudents are put in the role of a manager who watches inventory levels decrease and must order at the right time and in the right quantity to minimize costs. This interactive game requires the students to race against time and has levels of increasing difficulty. It introduces the students to the concepts of holding cost, ordering cost, backlog cost, the sawtooth curve, reorder point, order quantity, ABC categorization, and continuous review systems. The game is simple and is available free online. An accompanying assignment is designed to guide the student's reflection process while playing the game.
The “Living” Case: Structuring Storytelling to Increase Student Interest, Interaction, and Learning
Authors: Fawcett Stanley E , Fawcett Amydee M. 
Published: June 2011

ABSTRACTStorytelling has always been a powerful form of teaching and continues to be a compelling way to build and communicate theory. Storytelling brings learning to life, helping students grasp the intricacies and nuances of today's challenging decision‐making environment. One form of classroom storytelling involves the use of guest speakers. Carefully selected guest speakers bring a unique credibility to the classroom. However, integrating guest speakers into the curriculum is not without challenges. For example, although they possess valuable experience, not all guest speakers are (1) engaging, (2) familiar with the course content and learning objectives, and (3) versed in effective pedagogy. According to student feedback, poorly planned guest speaker interactions can actually diminish the learning experience. Bringing greater structure to the guest speaker's visit can help mitigate these challenges and make the most out of precious class time and guest speaker experience. Structured storytelling via guest‐speaker‐specific case studies perform this role.
A picture is worth a thousand words,A metaphor is worth a thousand pictures.           —Daniel Pink, A Whole New Mind
Using Toyota's A3 Thinking for Analyzing MBA Business Cases
Authors: Anderson Joe S. , Morgan James N. , Williams Susan K. 
Published: June 2011

ABSTRACTA3 Thinking is fundamental to Toyota's benchmark management philosophy and to their lean production system. It is used to solve problems, gain agreement, mentor team members, and lead organizational improvements. A structured problem‐solving approach, A3 Thinking builds improvement opportunities through experience. We used The Toyota Way to introduce these concepts and practices and we incorporated A3 Thinking into the case analysis dimension of our functionally integrated MBA class, Managing People and Processes. Results of A3 Thinking were communicated by the A3 report, using a single 11” by 17” sheet of paper. We surveyed students at the end of the semester, after they had created numerous A3 reports for case analysis. In addition to reinforcing A3 Thinking concepts, students and faculty found that A3 reporting added value to case analysis, class discussions, and presentations and pushed the focus of analysis into key issues and root causes often overlooked in a more intuitive approach. Emphasis on conciseness and graphics helped students improve communication and the format of the A3 reports helped instructors quickly review and evaluate the case analyses.
Ureteral endometriosis and loss of renal function: mechanisms and interpretations
Authors: LANGEBREKKE ANTON , QVIGSTAD ERIK 
Published: June 2011

AbstractUreteral endometriosis is associated with deep endometriosis and is relatively uncommon. In some patients, progressive obstruction of the lower part of the ureter may occur, with silent loss of renal function as a consequence. We report on three patients with loss of renal function, in whom different pathogenic mechanisms probably were the decisive cause. Failure to diagnose deep endometriosis with ureteral involvement, misinterpretation of hydroureter at magnetic resonance imaging and lack of typical symptoms may all be reasons for development of loss of renal function. With only one functional kidney, these patients should be followed closely with renal function tests and ultrasound, and in certain cases also by magnetic resonance imaging or renal scintigraphy.
Lack of influence of the Schneiderian membrane in forming new bone apical to implants simultaneously installed with sinus floor elevation: an experimental study in monkeys
Authors: Scala Alessandro , Botticelli Daniele , Faeda Rafael Silveira , Garcia Rangel Idelmo , Américo de Oliveira José , Lang Niklaus P. 
Published: June 2011

Abstracts
Aim: To describe the early healing processes around the implants installed after elevation of the sinus mucosa applying the lateral access technique without the use of grafting material.
Material and methods: Immediately after the elevation of the maxillary sinus Schneiderian membrane by the lateral approach in eight monkeys, implants were installed without the use of grafting material. The healing of the tissue around the implants was evaluated after 4, 10, 20 and 30 days. Ground sections were prepared and analyzed histologically.
Results: After 4 days of healing, the formation of coagulum and provisional matrix was documented within the elevated area. At 10‐day interval, sprouts of woven bone were in continuity with the parent bone, and partly in contact with the implant surface at the base of the augmented area. While bone‐to‐implant contact increased after 20 and 30 days, the area underneath the Schneiderian membrane appeared reduced in volume and condensed toward the apex of the implants. The sinus mucosa was to some extent collapsed onto the implant surface and on the newly formed bone.
Conclusions: The void initially occupied by the coagulum after sinus membrane elevation shrank substantially during the observation period. A lack of influence of the Schneiderian membrane in bone formation apical to implants was documented in the early phase of healing.
To cite this article: Scala A, Botticelli D, Faeda RS, Rangel IG Jr, de Oliveira, JA, Lang NP. Lack of influence of the Schneiderian membrane in forming new bone apical to implants simultaneously installed with sinus floor elevation: an experimental study in monkeys. Clin. Oral Impl. Res. 23, 2012; 175–181.  doi: 10.1111/j.1600‐0501.2011.02227.x
Melatonin promotes adventitious root regeneration in in vitro shoot tip explants of the commercial sweet cherry rootstocks CAB‐6P (Prunus cerasus L.), Gisela 6 (P. cerasus × P. canescens), and MxM 60 (P. avium × P. mahaleb).
Authors: Sarropoulou Virginia N. , Therios Ioannis N. , Dimassi‐Theriou Kortessa N. 
Published: June 2011

Abstract:  The objectives of this study were to test the effects of melatonin (N‐acetyl‐5‐methoxytryptamine), a natural compound of edible plants on the rooting of certain commercial sweet cherry rootstocks. Shoot tip explants from previous in vitro cultures of the cherry rootstocks CAB‐6P (Prunus cerasus L.), Gisela 6 (P. cerasus × P. canescens), and M × M 60 (P. avium × P. mahaleb) were included in the experiment. The effect of indole‐3‐acetic acid (IAA) and indole‐3‐butyric acid (IBA) alone or in combination with melatonin was tested concerning their rooting potential. Seven concentrations of melatonin (0, 0.05, 0.1, 0.5, 1, 5, and 10 μm) alone or in combination with 5.71 μm of IAA or 4.92 μm of IBA were tested. For each rootstock, 21 treatments were included. The explants were grown in glass tubes containing 10 mL of substrate. The parameters measured include rooting percentage, number of roots per rooted explant, root length, and callus formation. The data presented in this study show that melatonin has a rooting promoting effect at a low concentration but a growth inhibitory effect at high concentrations. In the absence of auxin, 1 μm melatonin had auxinic response concerning the number and length of roots, but 10 μm melatonin was inhibitory to rooting in all the tested rootstocks. The final conclusion of this experiment is that exogenously applied melatonin acted as a rooting promoter and its action was similar to that of IAA.