bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of updates in headache quality measures on adherence to best practices in a neurology resident clinic: A quality improvement study
Authors: Cascella Robert H. , Anderson Christopher C. , Perez Enmanuel J. 
Published: June 2024

AbstractObjectiveTo apply the 2019 joint American Academy of Neurology (AAN) and American Headache Society (AHS) quality measures for headache management to a cohort of neurology resident physicians and then assess outcomes related to guideline adherence.BackgroundThe optimization of headache management is essential to reduce both the individual and systemic impact of these disorders. In 2014, the AAN developed 10 quality measures for evidence‐based management of patients with headache. A workgroup updated and condensed its headache quality measures in 2019, narrowing the set to six measurements, four of which would primarily focus on the management of migraine and two of which would address the management of cluster headache.MethodsThis quality improvement study was conducted using a pretest‐posttest study design. A pre‐intervention survey based on retrospective analysis of five clinic notes for adherence to the measures was designed and distributed to all neurology residents (n = 32) at a large, academic tertiary referral center. The intervention included the creation of an electronic medical record template to aid residents in following the measures during clinical encounters, as well as the provision of direct feedback based on pre‐intervention results. Finally, a post‐intervention survey was distributed for completion based on notes written during the intervention period. Analysis was limited to migraine, given the low percentage of cluster headache seen in clinic.ResultsAn increase in adherence was seen in three of the four migraine‐related quality measures, with the Use of Abortive Medications for Migraine and Documentation of Counseling on Modifiable Lifestyle and Chronification Factors demonstrating statistically significant improvements (75.8% to 88.0% [p = 0.013] and 83.9% to 94.0% [p = 0.029] adherence, respectively). For secondary outcomes, the increase in the utilization of appropriate diagnostic criteria (82.6% to 93.2%, p = 0.018) was significant, and the self‐assessed confidence rating for adherence to guidelines was significant (p < 0.001).ConclusionsThis study provides evidence that the quality improvement intervention led to increased adherence to the AAN and AHS migraine‐related measures. It is anticipated that increased adherence may lead to improved patient outcomes.
Expanding the spectrum of low‐grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating HRAS/AKT1 mutations
Authors: Hadnagy Viktoria S , Körner Meike , Rössle Matthias , Dubach Patrick , Pabst Gunther , Kotulova Alexandra , Weder Stefan , Seifert Robert , Rushing Elisabeth J , Holzmann David , Hüllner Martin , Freiberger Sandra N , Rupp Niels J 
Published: June 2024

AimsLow‐grade non‐intestinal‐type sinonasal adenocarcinoma (LGSNAC) is a rare heterogeneous and poorly characterised group of tumours, distinct from intestinal‐ and salivary‐type neoplasms. Therefore, further characterisation is needed for clearer biological understanding and classification.Methods and resultsClinical, histological and molecular characterisation of four cases of biphasic, low‐grade adenocarcinomas of the sinonasal tract was performed. All patients were male, aged between 48 and 78 years, who presented with polypoid masses in the nasal cavity. Microscopically, virtually all tumours were dominated by tubulo‐glandular biphasic patterns, microcystic, focal (micro)papillary, oncocytic or basaloid features. Immunohistochemical staining confirmed biphasic differentiation with an outer layer of myoepithelial cells. Molecular profiling revealed HRAS (p.G13R, p.Q61R) mutations, and concomitant AKT1 (p.E17K, p.Q79R) mutations in two cases. Two cases showed potential in‐situ/precursor lesions adjacent to the tumour. Follow‐up periods ranged from 1 to 30 months, with one case relapsing locally after 12 and > 20 years.ConclusionThis study further corroborates a distinct biphasic low‐grade neoplasm of the sinonasal tract with seromucinous differentiation. Although morphological and molecular features overlap with salivary gland epithelial–myoepithelial carcinoma, several arguments favour categorising these tumours within the spectrum of LGSNAC.
Autophagy regulates bone loss via the RANKL/RANK/OPG axis in an experimental rat apical periodontitis model
Authors: Wu Zhiwu , Duan Shaoying , Li Mingming , Zhang Aopeng , Yang Hui , Luo Jingjing , Cheng Ran , Hu Tao 
Published: June 2024

AbstractAimAutophagy is involved in human apical periodontitis (AP). However, it is not clear whether autophagy is protective or destructive in bone loss via the receptor activator of nuclear factor‐κB ligand (RANKL)/RANK/osteoprotegerin (OPG) axis. This study aimed to investigate the involvement of autophagy via the RANKL/RANK/OPG axis during the development of AP in an experimental rat model.MethodologyTwenty‐four female Sprague–Dawley rats were divided into control, experimental AP (EAP) + saline, and EAP + 3‐methyladenine (An autophagy inhibitor, 3‐MA) groups. The control group did not receive any treatment. The EAP + saline group and the EAP + 3‐MA group received intraperitoneal injections of saline and 3‐MA, respectively, starting 1 week after the pulp was exposed. Specimens were collected for microcomputed tomography (micro‐CT) scanning, histological processing, and immunostaining to examine the expression of light chain 3 beta (LC3B), RANK, RANKL, and OPG. Data were analysed using one‐way analysis of variance (p < .05).ResultsMicro‐CT showed greater bone loss in the EAP + 3‐MA group than in the EAP + saline group, indicated by an elevated trabecular space (Tb.Sp) (p < .05). Inflammatory cell infiltration was observed in the EAP + saline and EAP + 3‐MA groups. Compared with EAP + saline group, the EAP + 3‐MA group showed weaker expression of LC3B (p < .01) and OPG (p < .05), more intense expression of RANK (p < .01) and RANKL (p < .01), and a higher RANKL/OPG ratio (p < .05).ConclusionAutophagy may exert a protective effect against AP by regulating the RANKL/RANK/OPG axis, thereby inhibiting excessive bone loss.
IL‐10 indirectly modulates functional activity of CD4+CD28null T‐lymphocytes through LFA‐3 and HLA class II inhibition
Authors: García‐Torre Alejandra , Bueno‐García Eva , Moro‐García Marco A. , López‐Martínez Rocío , Rioseras Beatriz , Díaz‐Molina Beatriz , Lambert José Luis , Alonso‐Arias Rebeca 
Published: June 2024

AbstractExpansion of CD4+CD28null T‐lymphocytes is common in chronic heart failure (CHF) patients. Its ability to produce high levels of proinflammatory cytokines is probably the key role of these cells in CHF. IL‐10 is a candidate for limiting CD4+CD28null T‐lymphocyte responses, whereas tumour necrosis factor (TNF) is the cytokine most closely involved in the loss of CD28 expression. Serum levels of TNF and IL‐10 were measured in 65 CHF patients (mean age, 65.2 ± 13.84 years). Patients with an IL‐10/TNF ratio ≥1 had significantly lower levels of CD4+CD28null T‐lymphocytes than those with a ratio <1. In vitro, IL‐10 reduced the frequency of proliferative CD4+CD28null T‐lymphocytes stimulated with anti‐CD3. Pre‐treatment with IL‐10 before anti‐CD3 stimulation was required for the cytokine to inhibit TNF production by CD4+CD28null T‐lymphocytes. In addition to the previously described effect of IL‐10 on HLA‐DR and ICAM‐1 expression, LFA‐3 protein and mRNA levels were reduced in the presence of the cytokine in monocytes. IL‐10 inhibition on CD4+CD28null T‐lymphocytes may be mediated by a reduction in HLA class II and LFA‐3 expression because blocking interactions with these costimulators has similar effects to those of IL‐10 treatment. Moreover, costimulation through CD2/LFA‐3 interaction is enough to induce proliferation and cytokine production in CD4+CD28null T‐lymphocytes.
Continuous glucose monitoring for black older adults with type 2 diabetes mellitus: Challenges, innovations and implications: A discursive review
Authors: Owusu Brenda , Bivins Balkys , Juste Judith , Francis Lucine , Itambo Jacqueline , Akomah Janelle , Yorukoglu Neslihan , Gbaba Serina , Hinneh Thomas , Ajibewa Tiwaloluwa , Commodore‐Mensah Yvonne , Baptiste Diana‐Lyn 
Published: June 2024

AbstractAimTo conduct a discursive review on continuous glucose monitoring use among Black older adults and to address the issue of racial disparities in diabetes management and outcomes. Type 2 diabetes mellitus is a global health concern with significant complications and mortality rates. Black older adults are disproportionately affected. Initially designed for type 1 diabetes, continuous glucose monitoring has emerged as an innovative tool for type 2 diabetes mellitus management. Despite its potential, there are challenges related to adherence and digital literacy among Black older adults for managing Diabetes.DesignA discursive review.MethodsSearching literature in PubMed, Scopus, and Google Scholar for papers published from 2017 to 2023, we explored the use of continuous glucose monitoring in Black older adults with type 2 diabetes mellitus, examining barriers, facilitators and challenges.DiscussionWe highlight recommendations from the literature which included barriers, facilitators, and cultural factors associated with continuous glucose monitoring use. Findings underscore the importance of addressing these challenges to reduce racial–ethnic disparities in type 2 diabetes mellitus management among Black older adults. Nurses and advanced practice registered nurses are at the forefront and can play a pivotal role in exploring and implementing interventions to promote access and proper use of continuous glucose monitoring among Black older adult patients with type 2 diabetes mellitus.
Private security and public police
Authors: Grunwald Ben , Rappaport John , Berg Michael 
Published: June 2024

AbstractPrivate security officers outnumber police by a wide margin, and the gap may be growing. As cities have claimed to defund the police, many have quietly expanded their use of private security, reallocating spending from the public to the private sector. It is difficult to know what to make of these trends, largely because we know so little about what private security looks like on the ground. On one prevalent view of the facts, a shift from public to private security would mean little more than a change of uniform, as the two labor markets are deeply intertwined. Indeed, academics, the media, popular culture, and the police themselves all tell us that private security is some amalgam of a police retirement community and a dumping ground for disgraced former cops. But if, instead, private officers differ systematically from the public police—and crossover between the sectors is limited—then substitution from policing to private security could drastically change who is providing security services.We bring novel data to bear on these questions, presenting the largest empirical study of private security to date. We introduce an administrative dataset covering nearly 300,000 licensed private security officers in the State of Florida. By linking this dataset to similarly comprehensive information about public law enforcement, we have, for the first time, a nearly complete picture of the entire security labor market in one state. We report two principal findings. First, the public and private security markets are predominantly characterized by occupational segregation, not integration. The individuals who compose the private security sector differ markedly from the public police; they are, for example, significantly less likely to be white men. We also find that few private officers, roughly 2%, have previously worked in public policing, and even fewer will go on to policing in the future. Second, while former police make up a small share of all private security, roughly a quarter of cops who do cross over have been fired from a policing job. In fact, fired police officers are nearly as likely to land in private security as to find another policing job, and a full quarter end up in one or the other. We explore the implications of these findings, including intersections with police abolition and the future of policing, at the paper's close.
Validation of the Japanese Version of the Modest Behavior Scale for Adults and Age and Gender Differences
Authors: Yamazaki Mizuki 
Published: June 2024

AbstractSocial pressures, such as cultural norms of modesty, are thought to contribute to low self‐esteem in East Asians, and modesty is a key concept in understanding the feelings, thoughts, and social behaviors of this population. Modesty has been found to encompass three aspects: avoidance of attention‐seeking (AA), self‐effacement (SE), and other‐enhancement (OE). The current study validated the Modest Behavior Scale and examined age and gender differences in the three aspects of modesty in a sample of adults aged 20–69 years. A total of 400 Japanese individuals participated in the online survey. The results of hierarchical multiple regression analyses and simple slopes analyses revealed that older people tend not to seek attention but also not to devalue themselves, whereas younger people tend to devalue themselves but not to refrain from seeking attention. This implies that people in different age groups use different modesty strategies. In addition, gender differences were found in AA and OE. The age and gender differences in modesty were discussed in terms of hierarchical relationships and social role expectations.
Long‐term effects of meadow management on seed bank diversity and composition
Authors: Hábenczyus Alida A. , Weiterová Iva , Foremnik Kacper , Jakob Aljaž , Khopkar Siddharth , Kumar Agnishikhe , Lazăr Anamaria , Paganeli Bruno , Samraoui Kenz Raouf , Sidwell Jeni , Hrček Jan , Lepš Jan , Segrestin Jules 
Published: June 2024

AbstractAimsOligotrophic grasslands are habitats that host among the most diverse plant communities in Europe. Altering management regimes by either intensifying or ceasing management is known to decrease plant diversity. Yet, despite its importance for the recovery of plant communities after disturbances, little is known about whether seed banks are also affected by changes in management. Here, we investigate the effect of management practices on a meadow seed bank using a long‐term manipulative experiment. We focus on the response of the seed bank to the treatments, and the relationship between the seed bank and the vegetation response.MethodsThe study was conducted in a species‐rich wet meadow. The experiment consists of a factorial combination of fertilization, mowing, and removal of the dominant species. After 20 years of management, the seed bank was sampled seasonally at two soil layer depths. Standing vegetation was recorded in June at the peak of vegetation.ResultsAll seed bank characteristics varied between soil layers. Mowing decreased seed density and diversity, while fertilization significantly affected the species composition. Dominant removal had no effect on the seed bank. While seed bank diversity was not correlated to vegetation diversity, individual species' responses to mowing and fertilization were positively correlated in the seed bank and the vegetation.ConclusionsOur results show that long‐term management influences the seed bank down to 10 cm of soil depth. Whereas mowing apparently reduced seed density and diversity, the effects of fertilization on these characteristics were harder to interpret. After 20 years, most species had concordant responses to both mowing and fertilization, indicating a low legacy of previous management regimes on the seed bank. Our study reveals that the intensification of grassland management has a profound effect on plant diversity by directly affecting plant communities and their seed‐bank‐driven recovery potential.
From diverticulosis to complicated diverticular disease: Progression of myogenic alterations and oxidative imbalance
Authors: Pallotta Lucia , Pisano Annalinda , Vona Rosa , Cappelletti Martina , Pignataro Maria Gemma , Tattoli Ivan , Maselli Maria Antonietta , Tarallo Mariarita , Casella Giovanni , Caronna Roberto , Tancredi Andrea , Scotti Giorgia Burrelli , Scalese Giulia , Matarrese Paola , Giordano Carla , Severi Carola 
Published: June 2024

AbstractBackgroundThe natural history and pathophysiology of diverticular disease (DD) are still uncertain. An ex‐vivo human complicated DD (cDD) model has recently shown a predominant transmural oxidative imbalance. The present study aims to evaluate whether the previously described alterations may precede the symptomatic form of the disease.MethodsColonic surgical samples obtained from patients with asymptomatic diverticulosis (DIV), complicated DD, and controls were systematically and detailed morphologically and molecularly analyzed. Therefore, histologic, histomorphometric, immunohistochemical evaluation, and gene and protein expression analysis were performed to characterize colonic muscle changes and evaluate chronic inflammation, oxidative imbalance, and hypoxia. Functional muscle activity was tested on strips and isolated cells in response to contractile and relaxant agents.Key ResultsCompared with controls, DD showed a marketed increase in muscle layer thickness, smooth muscle cell syncytium disarray, and increased interstitial fibrosis; moreover, the observed features were more evident in the cDD group. These changes mainly affected longitudinal muscle and were associated with altered contraction‐relaxation dynamics and fibrogenic switch of smooth muscle cells. Chronic lymphoplasmacytic inflammation was primarily evident in the mucosa and spared the muscle. A transmural increase in carbonylated and nitrated proteins, with loss of antioxidant molecules, characterized both stages of DD, suggesting early oxidative stress probably triggered by recurrent ischemic events, more pronounced in cDD, where HIF‐1 was detected in both muscle and mucosa.Conclusion & InferencesThe different DD clinical scenarios are part of a progressive process, with oxidative imbalance representing a new target in the management of DD.
Efficacy and safety of once‐weekly subcutaneous semaglutide on weight loss in patients with overweight or obesity without diabetes mellitus—A systematic review and meta‐analysis of randomized controlled trials
Authors: Kommu Sharath , Berg Richard L. 
Published: June 2024

SummarySemaglutide is found to be efficient for weight loss in patients with overweight or obesity with diabetes mellitus (DM). With a wide range of adverse events reported, the efficacy and safety of once‐weekly subcutaneous semaglutide in individuals without DM, with overweight or obesity, is unclear. We conducted a comprehensive meta‐analysis of randomized studies on once‐weekly semaglutide in this patient population. We identified nine studies with 11,641 patients in the semaglutide group and 10,479 in the placebo group. We observed that semaglutide resulted in significant benefits, including change in body weight (%): mean difference (MD) of −11.49% (p < 0.0001), change in absolute body weight: MD of −11.74 kg (p < 0.0001), and change in waist circumference: MD of −9.06 cm (p < 0.0001). Gastrointestinal side effects are predominant including nausea: odds ratio (OR) of 4.06 (p < 0.0001), vomiting: OR of 4.43 (p < 0.0001), diarrhea: OR of 2.10 (p < 0.0001), constipation: OR of 2.43 (p < 0.0001), gallbladder disorders: OR of 1.26 (p = 0.010), and cholelithiasis: OR of 2.06 (p = 0.04). Serious adverse events were not statistically significant: OR of 1.06 (p = 0.82). However, the percentage of participants discontinuing due to adverse events and gastrointestinal side effects was statistically significant: ORs of 2.22 (p < 0.0001) and 3.77 (p < 0.0001), respectively. This study shows that in patients with overweight or obesity without DM, once‐weekly subcutaneous semaglutide can significantly decrease body weight without risk of serious adverse events when compared with a placebo. However, gastrointestinal side effects are predominant with semaglutide, which can result in medication discontinuation.
Fitting emotions and virtuous judgment
Authors: D'Arms Justin 
Published: June 2024

AbstractI discuss a tension between two broadly Aristotelian ideas about the role of emotions in virtue and consider its implications for the original and attractive theory of virtuous judgment that Gopal Sreenivasan develops in Emotion and Virtue. One is the idea that a virtuous person has fitting emotions. The other idea is that the virtuous person has emotions that point her toward performing a virtuous action. I explain the tension between these ideas, and how it arises with respect to both of Sreenivasan's central examples of virtue: compassion and courage.I suggest that this tension generates some interesting and systemic respects in which a virtuous agent's virtuous emotional responses hamper her attempts to judge what is the virtuous thing to do. This makes me less sanguine than I take Sreenivasan to be about the contributions of emotion to the virtuous agent's reliability in passing his “Central Test of Virtue.”
Variants of NLRP3 Protein in Haemonchus contortus Infected Sheep: Impact on Immune Cell Responsiveness to LPS In Vitro
Authors: Middleton Denzel , Hanlon Kelly , Greiner Scott P. , Bowdridge Scott A. 
Published: June 2024

ABSTRACTPathogen recognition is an essential component to achieve the desired outcome of host protection. Nod‐like receptor pyrin containing domain 3 (NLRP3) is a cytoplasmic pattern recognition receptor (PRR) with a wide array of agonists, such as PAMPs, DAMPs, ATP, bacterial product and viral products. Stimulation of the NLRP3 inflammasome results in proteolytic activation of IL‐1β and IL‐18, cell pyroptosis and classically, the induction of proinflammatory responses. St. Croix (STC) sheep have resistance traits exhibiting the appropriate T‐helper type 2 immune response ensuing protection during helminth parasitic infection whereas parasite‐susceptible Suffolk (SUF) sheep have an impaired response resulting in parasite establishment and adverse symptoms. The objective of these experiments was to determine if NLRP3 protein in H. contortus‐infected SUF sheep was defective using the classical activation pathway of NLRP3 inflammasome. Peripheral blood mononuclear cells (PBMCs) derived from H. contortus‐infected STC and SUF sheep were isolated from whole blood and treated (MCC950 treatment for 2 h followed by LPS treatment for 3 h, 1400 W treatment for 2 h followed by LPS treatment for 3 h, LPS treatment for 3 h or culture media for 3 h). qPCR analysis of LPS‐stimulated PBMC revealed an upregulation in inflammatory associated genes IL‐1β, TLR4, TNFα and NFκB (p < 0.0001) in STC PBMC and downregulation in IFNγ, IL‐6 and iNOS for SUF PBMC. Pharmacological inhibition of iNOS in SUF PBMC resulted in an upregulation in the expression of IFNγ. These preliminary data begin to discover a relationship between NLRP3 activation and TLR4 signalling in PBMC of STC and SUF sheep.