bluuebunny/crossref_metadata_2025_split huggingface dataset:
A telematics service discovery platform using the distributed peer‐to‐peer networking system
Authors: Huang Chung‐Ming , Yang Chia‐Ching , Tseng Chun‐Yu 
Published: May 2012

SUMMARYIn this paper, a distributed telematics peer‐to‐peer networking system is proposed to provide an efficient and feasible service discovery mechanism for mobile users. When mobile users travel on the road, they may request for some services from service providers to meet their demands. Mobile users in vehicles are assumed to go through a lot of regions, in which each region is associated with a region server. Related information of all service providers in a region is stored in its region server, and each region server is in charge of the service discovery requests from all vehicles located in its region. This paper focuses on the issues of developing a distributed peer‐to‐peer telematics service discovery networking system over the vehicular network environment for mobile users. To provide the communication mechanism for telematics service discovery among region server, mobile users, and service providers, the Telematics Service Markup Language is proposed. According to clients' demands, three types of query scenarios are proposed, which are (1) reference point based query, (2) continual query, and (3) route‐based query. Finally, we present usage examples and system implementation of distributed telematics peer‐to‐peer. Copyright © 2012 John Wiley & Sons, Ltd.
Cyclic Deformation of Powder Metallurgy Stainless Steel/Mg‐PSZ Composite Materials
Authors: Glage Alexander , Martin Stefan , Decker Sabine , Weigelt Christian , Junghanns Martin , Aneziris Christos G. , Martin Ulrich , Krüger Lutz , Biermann Horst 
Published: May 2012

AbstractIn this study, the low‐cycle fatigue (LCF) behavior of powder metallurgy stainless steel/MgO partially stabilized zirconia (Mg‐PSZ) composite materials is presented. The steel matrix based on conventional AISI 304 steel (1.4301) is reinforced with Mg‐PSZ. The investigated composite materials were manufactured using the spark plasma sintering (SPS) technique. Total strain‐controlled LCF tests were performed on materials containing 0, 5, and 10 vol% Mg‐PSZ, respectively, in order to evaluate the influence of the ceramic reinforcement. Electron backscatter diffraction (EBSD) measurements were applied to identify the locations where the martensitic phase transformations in the steel matrix and stress‐assisted as well as athermal martensitic phase transformations of the Mg‐PSZ ceramic reinforcement take place. The resulting cyclic deformation behavior is correlated with the microstructural features of the composite material.
Determination of structural changes in microwaved rice starch using Fourier transform infrared and Raman spectroscopy
Authors: Fan Daming , Ma Wenrui , Wang Liyun , Huang Jianlian , Zhao Jianxin , Zhang Hao , Chen Wei 
Published: May 2012

AbstractFTIR and confocal laser micro‐Raman spectroscopy methods were used to investigate the differences in chemical bond types, bond energy, and skeleton connection system between rice starch heated in a microwave and rice starch heated rapidly using a traditional method. The temperature of the peak absorption position of CH mode vibration of microwaved sample was lower and the temperature of peak position of CO related mode vibration on skeleton of microwaved sample were higher than those of the rapid heating sample, but there were no changes to other skeletal mode vibrations such as glycosidic linkage and pyranose ring. Overall, microwave‐heat treatment did not change the type of chemical groups in starch molecules, and induce the formation of new chemical group bonds, or change the way that they interact with each other in rice starch. Furthermore, the vibrational energy of the chemical‐bond of microwave‐treated rice starch changes gradually during the heating process.
The Flk1-Cre-Mediated Deletion of ETV2 Defines Its Narrow Temporal Requirement During Embryonic Hematopoietic Development
Authors: Wareing Sarah , Mazan Andrzej , Pearson Stella , Göttgens Berthold , Lacaud Georges , Kouskoff Valerie 
Published: May 2012

Abstract
During embryonic development, the emergence of hematopoiesis and vasculogenesis is tightly associated, with many transcription factors implicated in both developmental processes. Among those factors, ETV2 acts at the top of the hierarchy and controls the formation of both lineages. However, it is not known at which stage of mesoderm development ETV2 is acting and whether ETV2 activity is further required once mesodermal precursors have been specified to the hematopoietic and endothelial fates. In this study, we characterize the developmental window during which ETV2 expression is required for hematopoietic and endothelial development. Using cre-mediated deletion of ETV2, we demonstrate that ETV2 is acting prior to or at the time of FLK1 expression in mesodermal precursors to initiate the hematopoietic and endothelial program. Using the in vitro differentiation of embryonic stem cells as a model system, we further show that ETV2 re-expression in Etv2−/− Flk1-negative precursors drives hematopoiesis specification and switches on the expression of most genes known to be implicated in hematopoietic and endothelial development. Among the downstream targets of ETV2, we identify the transcription factors SCL, GATA2, and FLI1 known to operate a recursive loop controlling hematopoietic development. Surprisingly, SCL re-expression in Etv2−/− cells fully rescues hematopoiesis, while the re-expression of FLI1 or GATA2 promotes only a very limited rescue. Altogether, our data establish that ETV2 is required very transiently to specify mesodermal precursors to hematopoiesis and vasculogenesis and that SCL is one of the key downstream targets of ETV2 in controlling hematopoietic specification.
An optimal cooperative spectrum sensing strategy with exponential primary link traffic
Authors: Wang Qian , Yue Dian‐Wu , Yuan Jinhong 
Published: May 2012

ABSTRACTIn this paper, we investigate the optimal sensing settings for a cognitive radio (CR) network consisting a number of CR users and a fusion center (FC). Our objective is to maximize the channel utilization under the constraint that the signals from the primary user (PU) are sufficiently protected. We focus on the utilization of the channel in which PUs dynamically enter the network with burst nature. Thus, we apply the average error probability (AEP) as the metric of channel utilization. Moreover, in order to protect the PU signal from being interfered, the missing detection probability is applied as the constraint function. Assuming that counting rules are utilized in the FC, we derive the false alarm probability, the missing detection probability, and the AEP in the maximum a posteriori (MAP) fashion. Then, after proving the monotonic properties of the objective function and the constraint function, we propose an efficient algorithm named Algorithm I that can derive the optimal settings for maximizing the channel utilization. Moreover, a simplified algorithm named Algorithm II is also proposed to minimize the AEP, supposing that perfect synchronization exists between the CR users and the PU. Finally, we show our numerical results and compare our optimal results with those found by exhaustive searches. We conclude that our Algorithm I produces optimal results very close to those found by exhaustive searches. Performance comparison between Algorithms I and II is also provided in terms of the AEP and the probability of missing detection. Copyright © 2012 John Wiley & Sons, Ltd.
The representation of self and person knowledge in the medial prefrontal cortex
Authors: Wagner Dylan D. , Haxby James V. , Heatherton Todd F. 
Published: May 2012

AbstractNearly 40 years ago, social psychologists began applying the information processing framework of cognitive psychology to the question of how humans understand and represent knowledge about themselves and others. This approach gave rise to the immensely successful field of social cognition and fundamentally changed the way in which social psychological phenomena are studied. More recently, social scientists of many stripes have turned to the methods of cognitive neuroscience to understand the neural basis of social cognition. A pervasive finding from this research is that social knowledge, be it about one's self or of others, is represented in the medial prefrontal cortex (MPFC). This review focuses on the social cognitive neuroscience of self and person knowledge in the MPFC. We begin with a brief historical overview of social cognition, followed by a review of recent and influential research on the brain basis of self and person knowledge. In the latter half of this review, we discuss the role of familiarity and similarity in person perception and of spontaneous processes in self and other‐referential cognition. Throughout, we discuss the myriad ways in which the social cognitive neuroscience approach has provided new insights into the nature and structure of self and person knowledge. WIREs Cogn Sci 2012, 3:451–470. doi: 10.1002/wcs.1183This article is categorized under:

Neuroscience > Cognition
Control of germline stem cell self‐renewal and differentiation in the Drosophila ovary: concerted actions of niche signals and intrinsic factors
Authors: Ting Xie 
Published: May 2012

AbstractIn the Drosophila ovary, germline stem cells (GSCs) physically interact with their niche composed of terminal filament cells, cap cells, and possibly GSC‐contacting escort cells (ECs). A GSC divides to generate a self‐renewing stem cell that remains in the niche and a differentiating daughter that moves away from the niche. The GSC niche provides a bone morphogenetic protein (BMP) signal that maintains GSC self‐renewal by preventing stem cell differentiation via repression of the differentiation‐promoting gene bag of marbles (bam). In addition, it expresses E‐cadherin, which mediates cell adhesion for anchoring GSCs in the niche, enabling continuous self‐renewal. GSCs themselves also express different classes of intrinsic factors, including signal transducers, transcription factors, chromatin remodeling factors, translation regulators, and miRNAs, which control self‐renewal by strengthening interactions with the niche and repressing various differentiation pathways. Differentiated GSC daughters, known as cystoblasts (CBs), also express distinct classes of intrinsic factors to inhibit self‐renewal and promote germ cell differentiation. Surprisingly, GSC progeny are also dependent on their surrounding ECs for proper differentiation at least partly by preventing BMP from diffusing to the differentiated germ cell zone and by repressing ectopic BMP expression. Therefore, both GSC self‐renewal and CB differentiation are controlled by collaborative actions of extrinsic signals and intrinsic factors. WIREs Dev Biol 2013, 2:261–273. doi: 10.1002/wdev.60This article is categorized under:

Invertebrate Organogenesis > Flies
Adult Stem Cells, Tissue Renewal, and Regeneration > Tissue Stem Cells and Niches
Development of the cerebellum: from gene expression patterns to circuit maps
Authors: White Joshua J. , Sillitoe Roy V. 
Published: May 2012

AbstractThe internal structure of the cerebellum reflects an intriguing paradox; its cytoarchitecture is relatively simple and repeated throughout, yet the connections between its neurons are wired into a complex array of gene expression domains and functional circuits. The developmental mechanisms that coordinate the establishment of cerebellar structure and circuitry provide a powerful model for understanding how functional brain networks are formed. Two primary germinal zones generate the cells that make up the cerebellum. Each zone expresses a specific set of genes that establish the cell lineages within the cerebellar anlage. Then, cohorts of differentiated projection neurons and interneuron progenitors migrate into the developing cerebellum. Thereafter, a number of remarkable patterning events occur including transformation of the smooth cerebellar surface into an intricately patterned series of folds, formation of three distinct cellular layers, and the demarcation of parasagittal gene expression domains. Together, these structural and molecular organizations are thought to support the proper connectivity between incoming afferent projections and their target cells. After birth, genetic programs and neural activity repattern synaptic connections into topographic neural networks called modules, which are organized around a longitudinal zone plan and are defined by their molecular, anatomic, and functional properties. WIREs Dev Biol 2013, 2:149–164. doi: 10.1002/wdev.65This article is categorized under:

Nervous System Development > Vertebrates: Regional Development
W4Br10 Cluster Intermediates in the Solid State Nucleation of W6Br12
Authors: Ströbele Markus , Meyer H.‐Jürgen 
Published: May 2012

AbstractThe new adduct W4Br10·2SbBr3 and the new binary compound W4Br10 were obtained as products in a reaction cascade in which WBr6 was reacted with elemental antimony at successively increased temperatures. The crystal structures of both compounds were refined from X‐ray powder diffraction data and their electronic structures were analyzed by MO calculations. The cluster compounds W4Br10·2SbBr3 and W4Br10 appear as intermediates in the solid state nucleation of W6Br12. The overall reaction cascade involves tungsten clusters having tetrahedral (W4), square pyramidal (W5) and finally octahedral (W6) cluster cores.
29Si NMR Shielding Tensors in Triphenylsilanes – 29Si Solid State NMR Experiments and DFT‐IGLO Calculations
Authors: Brendler Erica , Heine Thomas , Seichter Wilhelm , Wagler Jörg , Witter Raiker 
Published: May 2012

Abstract 29Si NMR shielding tensors of a series of triphenylsilanes Ph3SiR with R = Ph, Me, F, Cl, Br, OH, OMe, SH, NH2, SiPh3, C≡CPh were determined from 29Si CP/MAS spectra recorded at low spinning rates. In addition the principal components of the shielding tensor were calculated employing the DFT‐IGLO method. For most silanes experimental and calculated values are in good accordance. Larger differences were observed for systems with hydrogen bridge forming substituents and the halides bromide and chloride. In some of the spectra the shielding information interfered with residual dipolar couplings. The different contributions of the various substituents to the principal components of the shielding tensor and the orientation of the tensor within the molecules are discussed and compared for the compounds under investigation.
Long‐term Survival in Hilar Cholangiocarcinoma also Possible in Unresectable Patients
Authors: Ruys Anthony T. , van Haelst Steven , Busch Olivier R. , Rauws Erik A. , Gouma Dirk J. , van Gulik Thomas M. 
Published: May 2012

AbstractBackgroundRadical resection remains the only curative treatment for hilar cholangiocarcinoma (HCCA). Only a limited proportion of patients, however, are eligible for resection. The survival and prognostic factors of these patients are largely unknown. The aim of this study was to evaluate survival and prognostic factors in unresectable patients presenting with HCCA.MethodsWe performed a cohort study of the denominator of HCCA patients seen in a tertiary referral center between March 2003 and March 2009. Demographics, treatment, pathology results, and survival were analyzed.ResultsA total of 217 patients with suspected HCCA were identified. Ninety‐five patients (40 %) underwent laparotomy, and in 57 (63 %) of these patients resection was performed. Overall median and 5‐year survival of resected patients were 37 months and 43 %, respectively, as compared to 13 months and 7 % in unresectable patients. In unresectable patients, median survival was better in patients with locally advanced disease (16 months) as compared to patients with hepatic and extrahepatic metastases (5 and 3 months, p < 0.001). Of the 160 unresectable patients, 17 (10 %) survived longer than 3 years.ConclusionOf the patients presenting with HCCA in our center, 26 % proved resectable. The 7 % long‐term survival rate of unresectable patients is remarkable and emphasizes the indolent growth of some of these tumors. Patients with metastases had a much worse prognosis with a median of 4 months.
Pontocerebellar hypoplasia type 6 caused by mutations in RARS2: definition of the clinical spectrum and molecular findings in five patients
Authors: Cassandrini Denise , Cilio Maria Roberta , Bianchi Marzia , Doimo Mara , Balestri Martina , Tessa Alessandra , Rizza Teresa , Sartori Geppo , Meschini Maria Chiara , Nesti Claudia , Tozzi Giulia , Petruzzella Vittoria , Piemonte Fiorella , Bisceglia Luigi , Bruno Claudio , Dionisi‐Vici Carlo , D'Amico Adele , Fattori Fabiana , Carrozzo Rosalba , Salviati Leonardo , Santorelli Filippo M. , Bertini Enrico 
Published: May 2012

AbstractRecessive mutations in the mitochondrial arginyl‐transfer RNA synthetase (RARS2) gene have been associated with early onset encephalopathy with signs of oxidative phosphorylation defects classified as pontocerebellar hypoplasia 6. We describe clinical, neuroimaging and molecular features on five patients from three unrelated families who displayed mutations in RARS2. All patients rapidly developed a neonatal or early‐infantile epileptic encephalopathy with intractable seizures. The long‐term follow‐up revealed a virtual absence of psychomotor development, progressive microcephaly, and feeding difficulties. Mitochondrial respiratory chain enzymes in muscle and fibroblasts were normal in two. Blood and CSF lactate was abnormally elevated in all five patients at early stages while appearing only occasionally abnormal with the progression of the disease. Cerebellar vermis hypoplasia with normal aspect of the cerebral and cerebellar hemispheres appeared within the first months of life at brain MRI. In three patients follow‐up neuroimaging revealed a progressive pontocerebellar and cerebral cortical atrophy. Molecular investigations of RARS2 disclosed the c.25A>G/p.I9V and the c.1586+3A>T in family A, the c.734G>A/p.R245Q and the c.1406G>A/p.R469H in family B, and the c.721T>A/p.W241R and c.35A>G/p.Q12R in family C. Functional complementation studies in Saccharomyces cerevisiae showed that mutation MSR1‐R531H (equivalent to human p.R469H) abolished respiration whereas the MSR1‐R306Q strain (corresponding to p.R245Q) displayed a reduced growth on non‐fermentable YPG medium. Although mutations functionally disrupted yeast we found a relatively well preserved arginine aminoacylation of mitochondrial tRNA. Clinical and neuroimaging findings are important clues to raise suspicion and to reach diagnostic accuracy for RARS2 mutations considering that biochemical abnormalities may be absent in muscle biopsy.
Virtual Reality Social Cognition Training for Young Adults with High-Functioning Autism
Authors: Kandalaft Michelle R. , Didehbani Nyaz , Krawczyk Daniel C. , Allen Tandra T. , Chapman Sandra B. 
Published: May 2012

AbstractFew evidence-based social interventions exist for young adults with high-functioning autism, many of whom encounter significant challenges during the transition into adulthood. The current study investigated the feasibility of an engaging Virtual Reality Social Cognition Training intervention focused on enhancing social skills, social cognition, and social functioning. Eight young adults diagnosed with high-functioning autism completed 10 sessions across 5 weeks. Significant increases on social cognitive measures of theory of mind and emotion recognition, as well as in real life social and occupational functioning were found post-training. These findings suggest that the virtual reality platform is a promising tool for improving social skills, cognition, and functioning in autism.
Report from the National Society of Genetic Counselors Service Delivery Model Task Force: A Proposal to Define Models, Components, and Modes of Referral
Authors: Cohen Stephanie A. , Gustafson Shanna L. , Marvin Monica L. , Riley Bronson D. , Uhlmann Wendy R. , Liebers S. Bonnie , Rousseau Julie A. 
Published: May 2012

AbstractThe Service Delivery Model Task Force (SDMTF) was appointed in 2009 by the leadership of the National Society of Genetic Counselors (NSGC) with a charge to research and assess the capacity of all existing service delivery models to improve access to genetic counseling services in the context of increasing demand for genetic testing and counseling. In approaching this charge, the SDMTF found that there were varying interpretations of what was meant by “service delivery models” and the group held extensive discussions about current practices to arrive at consensus of proposed definitions for current genetic service delivery models, modes of referral and components of service delivery. The major goal of these proposed definitions is to allow for conversations to begin to address the charge to the committee. We propose that current models of service delivery can be defined by: 1) the methods in which genetic counseling services are delivered (In‐person, Telephone, Group and Telegenetics), 2) the way they are accessed by patients (Traditional referral, Tandem, Triage, Rescue and Self‐referral) and 3) the variable components that depend upon multiple factors unique to each service setting. This report by the SDMTF provides a starting point whereby standardized terminology can be used in future studies that assess the effectiveness of these described models to overcome barriers to access to genetic counseling services.
Trans Isomers of EPA and DHA in Omega‐3 Products on the European Market
Authors: Sciotto Caterina , Mjøs Svein A. 
Published: May 2012

AbstractThe levels of trans isomers of eicosapentaenoic (EPA) acid and docosahexaenoic acid (DHA) in 77 omega‐3 products on the European market have been studied. Fatty acids were analyzed as fatty acid methyl esters by gas chromatography with a flame ionization detector, using a cyanopropyl coated stationary phase. The amount of mono‐trans EPA isomers relative to the corresponding all‐cis isomer ranged from 0.19 to 4.5 %. The corresponding values for mono‐trans DHA relative to the all‐cis isomer ranged from 0.25 to 5.9 %. There was a strong correlation between the degree of isomerization of EPA and DHA, showing that DHA was 1.26 times more isomerized than EPA. Division of the samples into different product groups showed that samples with a low degree of isomerization were found in all groups, except one. This shows that a high degree of isomerization is avoidable, and also points to deodorization of the oils as the main source of trans isomers.
LC–ESI–MS/MS Identification of Polar Lipids of Two Thermophilic Anoxybacillus Bacteria Containing a Unique Lipid Pattern
Authors: Řezanka Tomáš , Kambourova Margarita , Derekova Anna , Kolouchová Irena , Sigler Karel 
Published: May 2012

AbstractPhospholipids and glycolipids from two recently described species belonging to the thermophilic genus Anoxybacillus were analyzed by liquid chromatography–electrospray tandem mass spectrometry (LC/ESI–MS/MS). Analysis of total lipids from the facultatively anaerobic A. bogrovensis on a HILIC (Hydrophilic Interaction LIquid Chromatography) column succeeded in separating diacyl‐ and plasmalogen phospholipids. The LC/ESI–MS/MS analysis of the strict aerobe A. rupiensis revealed the presence of different unique polar lipids, predominantly alanyl‐, lysyl‐, and glucosyl‐phosphatidylglycerols and cardiolipins. Each of the classes of polar lipids was then analyzed by means of the ESI–MS/MS and more than 140 molecular species of six lipid classes from A.bogrovensis and nearly 200 molecular species of nine classes of polar lipids from A. rupiensis were identified. Five classes of unidentified polar lipids were detected in both strains. Plasmalogens were thus determined for the first time in a facultatively anaerobic bacterium, i.e. A. bogrovensis.