bluuebunny/crossref_metadata_2025_split huggingface dataset:
EVALUATION OF ATROMID S (CLOFIBRATE) IN HYPERLIPIDEMIC STATES
Authors: Hood B. , Angervall G. , Cramér K. , Welin G. 
Published: August 2010

Abstract Atromid S has been evaluated in an uncontrolled trial on a clinical material of hyperlipidemic states, comprising 354 individuals, including an unusually high number of cases of essential hypercholesterolemic xanthomatosis. Follow‐up periods varied between 1/2 and 41/2 years. Side‐effects, reasons for withdrawal, persistency of lipid‐lowering effects, rates of mortality and attacks of myocardial infarctions have been discussed. A significant and persistent lipid‐lowering effect was seen in all varieties. Although moderate, this was also apparent in severe hypercholesterolemic xanthomatosis.Mortality and infarction rates were low—as was also the frequency of side‐effects. No serious side‐effects were seen. The drug is considered to merit a considerable extension and prolongation of the study.
INTESTINAL CLOSTRIDIUM PERFRINGENS IN RHEUMATOID ARTHRITIS AND OTHER COLLAGEN DISEASES1
Authors: Olhagen Börje , Månsson Ingmar 
Published: August 2010

AbstractThe intestinal anaerobic flora has been studied, with special reference to Clostridium perfringens, in various collagen diseases, rheumatoid arthritis (R.A.) in particular, and in a series of control cases. The C. perfringens flora was qualitatively and quantitatively abnormal in two‐thirds of 186 R.A. cases, in two‐thirds of “entero‐arthritis” cases, in about half the S.L.E., the psoriatic‐arthritis, and the seronegative‐polyarthritis cases, but only in a few of the patients with pelvospondylitis ossificans and uro‐arthritis (Reiter's syndrome). An abnormal C. perfringens flora was not demonstrated in any of the patients with polyarthritis or arthralgia after tonsillitis, nor in any of the control cases. The alpha‐antitoxin titre in serum was raised in 78% of the R.A. cases, and such titre rises, which occurred parallel to the pathological C. perfringens flora, were also demonstrated in the cases of other inflammatory rheumatic diseases but were not noted in any of the control cases.The results of faeces cultures and serological examinations are analysed in relation to several clinical and laboratory parameters, such as the patient's age and sex, duration and activity of the disease, administered drugs, hypergammaglobulinaemia, and secretion of hydrochloric acid in the stomach. A tendency to higher frequency of abnormal C. perfringens flora is noted both in R.A. patients with high disease activity and in elderly patients.
WHOLE BODY HEMATOCRIT: LARGE VESSEL HEMATOCRIT RATIO IN HYPERTENSION
Authors: Hansen Jacob , Rønnov‐Jessen Vagn 
Published: August 2010

AbstractWhole body hematocrit/large vessel hematocrit (WBH/LVH ratio) has been examined in 21 normotensive and 35 hypertensive subjects and found to be the same, presumably as an expression of a uniform distribution of the blood volume in the two groups. Moderate renal impairment, the degree of the retinopathy, or the height of the diastolic blood pressure do not seem to influence the ratio figures.The WBH/LVH ratio was examined during treatment with various hypotensive drugs. A significant increase in the ratio was demonstrated during the influence of a single effective intravenous dose of pentolinium. Similar results were obtained during short‐term treatment with guanethidine alone and during long‐term treatment with guanethidine and hydrochlorothiazide.Treatment with hydrochlorothiazide alone caused an increase in ratio after one week and after three months, but these increases were not significant.The possible causes of these alterations in the WBH/LVH ratio are discussed. The advantage of employing a double isotope technique in preference to a quicker single isotope technique has been analyzed in relation to the determination of the total blood volume in patients during treatment with hypotensive drugs.
IG‐G, IG‐A AND IG‐M GRANULOCYTE‐REACTIVE ANTINUCLEAR FACTORS IN RHEUMATOID ARTHRITIS
Authors: Elling P. , Graudal H. 
Published: August 2010

Abstract Sera from 84 patients with rheumatoid arthritis were investigated for Ig, Ig‐G, Ig‐A, Ig‐M ANF reactive with nuclei of polymorphonuclear granulocytes, using a two‐ and three‐layer immunofluorescent antibody technique.Granulocyte‐reactive ANF were found in 2/3 of the sera. Of the 56 positive sera, 60% contained Ig‐G ANF, 62% Ig‐A and 67% Ig‐M ANF. Sera containing granulocyte‐reactive ANF exclusively of high molecular weight (Ig‐A and Ig‐M) constitute 39% of the positive sera.Granulocyte‐reactive ANF were found significantly more frequently in sera from patients 61 years old or older, owing to an increase of Ig‐G ANF. No sex difference was demonstrated. There was no statistically significant relationship between gran.‐react. ANF of the three human immunoglobulin classes and such clinical parameters as ESR, functional capacity or concentration of haemoglobin.A strict correlation between granulocyte‐reactive ANF and the presence of nodules was found, all patients with nodules showing a positive ANF reaction.Half the 56 positive sera reacted exclusively with nuclei of polymorphonuclear granulocytes, while the other half also reacted with other human nuclei. With advancing disease increasing non‐specificity of ANF occurred and a significantly higher proportion of sera from patients with long‐lasting disease also contained ANF reactive with other human nuclei. This increase in nuclear reactivity was accompanied by a change in the immunoglobulin pattern of granulocyte‐reactive ANF, the Ig‐G ANF being found significantly more frequently in sera from patients with disease of short duration, while Ig‐G ANF were present in a significantly higher proportion of sera from patients with more long‐lasting disease.
SELF‐INDUCED PROTEIN‐CALORIE MALNUTRITION IN A HEALTHY ADULT MALE
Authors: Jagenburg R. , Svanborg A. 
Published: August 2010

Abstract Clinical examination and analyses of a number of blood constituents including proteins, individual free amino acids, and lipids were performed in a 34‐year‐old athletic male, who first had been on a calorie‐deficient diet for seven months and then on a diet which was extremely low in proteins and lipids for 143 days.The concentrations of the different blood constituents were essentially normal, despite a marked weight reduction and other signs of advanced protein depletion. His physical capacity was obviously reduced, but he recovered very soon after the institution of an ordinary vegetarian diet.The observations indicate that a calorie‐ and protein‐deficient diet which is poor in sodium can be tolerated remarkably well by a healthy individual with extensive protein depots in the form of muscle tissue.
THE PHYSICAL FITNESS OF OLD NORWEGIAN MEN AND WOMEN
Authors: Benestad A. M. , Halvorsrud J. , Andersen K. Lange 
Published: August 2010

Abstract This study aimed at establishing the maximal level of aerobic power in old Norwegian people. Twenty men and ten women above the age of seventy were physically tested.Two thirds of all the subjects had ECG changes at rest and/or during exercise, but none of them had to stop the testing procedure.Compared to young people the old subjects had a maximal oxygen uptake which was reduced by 50%. Maximal heart rate as well as maximal oxygen pulse were considerably decreased, indicating a reduced cardiac output. This gives reason to suggest that the old heart has an impaired functional performance.The respiratory efficiency is also decreased, as indicated by the high ventilation equivalent.Although the subjects investigated do not represent a true random sample the result suggests that Norwegian people above seventy years of age possess an aerobic power or physical fitness which is only half of that at the age of 20–30 years.
BLOOD FLOW AND UPTAKE OF OXYGEN AND SUBSTRATES IN FOREARM MUSCLE AND SUBCUTANEOUS FAT TISSUE IN MAN
Authors: Häggendal Egil , Kerstell Jüri , Steen Bertil , Svanborg Alvar 
Published: August 2010

Abstract Blood flow and arteriovenous differences in oxygen, glucose, lactate, pyruvate, free fatty acids, glycerol, acetoacetate, and β‐hydroxybutyrate were measured in forearm muscle tissue before, during and after insulin infusion, in healthy and diabetic subjects. The same metabolic data were collected for forearm subcutaneous fat tissue.Significant correlations were obtained between the flow and the oxygen uptake in the two tissues both before and after insulin. On the other hand there were no correlations between the flow and the uptake of any single substrate or the total net uptake of the substrates. Concerning the arterial levels of the substrates there was a significant correlation between that of free fatty acids in the diabetics and the muscle blood flow.
THE CAUSE OF ARTERIAL HYPOXEMIA IN ACUTE MYOCARDIAL INFARCTION
Authors: Storstein O. , Rasmussen K. 
Published: August 2010

Abstract The mechanism of arterial hypoxemia, commonly found in patients with acute myocardial infarction, has been studied in 24 patients with polarographic determination of arterial pO2 before and after ten minutes of pure oxygen breathing.Most of the patients have a reduction in arterial pO2 on air breathing and do not attain normal values for pO2 on oxygen breathing. Patients in shock or with pulmonary congestion show more severely reduced values of pO2 both on air breathing and on oxygen breathing. Calculation of the so‐called physiological shunt on air breathing and the so‐called anatomical shunt on oxygen breathing demonstrates that most of the reduction in arterial pO2 is due to disturbance of the ventilationperfusion relationships in the lungs, but a considerable amount of the reduction in pO2 is caused by shunting of pulmonary arterial blood through non‐ventilated parts of the lungs.
GASTRIC HISTOLOGY AND AUTOANTIBODIES IN PERNICIOUS ANEMIA
Authors: Rødbro Paul , Faber Viggo , Dige‐Petersen Harriet , Howitz Jette 
Published: August 2010

Abstract The gastric histology and occurrence of anti‐nuclear factors and circulating autoantibodies against intrinsic factor, parietal cell and thyroid cell cytoplasm and mitochondria were studied in 28 patients with Addisonian pernicious anemia in remission. The data were analysed with respect to relations between gastric histology, autoantibodies in serum, age and sex of patients, and duration of pernicious anemia.Intrinsic factor antibody was not found in patients with gastric atrophy, who had a slightly higher mean age than was found in the patients with atrophic gastritis.Parietal cell antibody was found in all patients below 60 years of age, but apart from these findings no clear‐cut relations could be derived from the data.The significance of the gastric autoantibodies is discussed. It is concluded that intrinsic factor antibody secreted into gastric juice may neutralise intrinsic factor, and that the production of this antibody may be the crucial factor in the evolution of overt pernicious anemia. So far no direct evidence has been produced to show that the gastric autoantibodies play a role in the pathogenesis of the gastric lesion.
ON THE CONTENT OF MYOGLOBIN IN HUMAN MUSCLES
Authors: Åkeson Åke , Biörck Gunnar , Simon Rosemarie 
Published: August 2010

Abstract A quantitative method of determining the content of myoglobin and hemoglobin in human muscle is described.A piece of muscle, 1–4 g, is ground with dry ice, homogenized and extracted with 0.02 M phosphate buffer, pH 7.4. After being centrifuged at 15,000 × g, the solution is concentrated by dialysis against 25% polyethylene glycol solution. The hemoproteins are separated by gel filtration on Sephadex G 75, identified by the absorption spectra of their carbon monoxide compounds and quantitatively determined by the pyridine hemochrome method.The content of hemoprotein is calculated as per cent of dry weight, the latter being determined on the original homogenate.In an autopsy material, mainly consisting of patients in upper age‐groups with chronic disease and modest physical activity, average values of 0.9 g myoglobin per 100 g dry muscle were found in hearts (left ventricle), whereas corresponding values for diaphragm, abdominal muscle and muscles of the thigh were 1.1, 1.6 and 2.2 g per 100 g dry muscle. It is assumed that values in healthy adults may well be somewhat higher. From these values it is calculated that the total amount of myoglobin in an adult male is in the range of 120–150 g, corresponding to an iron pool of 0.37‐0.47 g or approximately 7/5 of the amount of hemoglobin iron.Comparisons with determinations arrived at by other methods are made, and some aspects of the physiology of myoglobin and other hematin compounds are discussed.The insoluble or “residual” hematin has been determined. It could be shown that the major part of this hematin can be accounted for by the mitochondrial hemoproteins, the remaining part in all probability deriving from hemoglobin.
THE RELATIONSHIP BETWEEN PLASMA RENIN ACTIVITY AND HEMOCONCENTRATION
Authors: Nielsen Ingolf , Møller Inge 
Published: August 2010

Abstract The relationship between renin activity and hemoconcentration determined by colloid osmotic pressure has been studied during changes in posture and acute studies on subjects given a diuretic.1. Renin activity increased, on an average, three times from supine to standing position. There is no difference between the values after 20 and 40 minutes of standing and the values obtained after 4–5 hours of quiet walking. The increase takes place between the 10th and 20th minute after standing position has been assumed. 2. COP increase precedes the increase in renin activity. In the first five minutes 60% of the maximum increase has been attained. A plateau is reached after 20 minutes of standing. 3. A close, linear relationship between Δ COP and Δ renin activity is demonstrated.Two possibilities of a causal relationship arise: (a) renin activity increase is a function of blood volume loss, in these conditions concomitant with hemoconcentration; (b) renin activity is a function of hemoconcentration, in these experiments expressed by COP.As post‐hemorrhage blood volume loss does not stimulate an increase in renin activity, the second possibility is favoured.An influence of postural pooling on the rise in renin activity can be ruled out, as a rise of the same order in COP and in plasma renin activity are found in the furosemide studies, where no pooling occurs.
DEPRESSION OF ISOPRENALINE‐INDUCED IDIOVENTRICULAR RHYTHM IN MAN BY BETA‐ADRENERGIC RECEPTOR BLOCKING AGENTS
Authors: Michaeli Ernst , Rosén Anders 
Published: August 2010

AbstractA method for studying drug effects on cardiac automaticity in man is presented.During the treatment for Stokes‐Adams disease emergency resuscitation from ventricular standstill can be effected by the arousal of intrinsic ventricular pacemakers. Isoprenaline seems to be a useful drug to produce idioventricular rhythm, but as shown in the present investigation its effect varies widely from patient to patient.The isoprenaline‐induced increase in the ventricular automaticity was depressed by the beta‐receptor blocking compounds propranolol and INPEA. The compounds seemed to block this effect of isoprenaline more easily than the effect of isoprenaline on the sino‐atrial rate. The observations indicate that adrenergic beta‐receptors are significantly involved in the control of cardiac automaticity in man.The observed effects of the beta‐receptor blocking drugs have an important clinical implication. In patients treated with the drugs the efficiency of beta‐mimetic substances in emergency resuscitation from ventricular standstill may be critically reduced.
MUSCLE BLOOD FLOW, MEASURED BY XENON133AND VASCULAR CALCIFICATIONS IN DIABETICS
Authors: Christensen Niels Juel 
Published: August 2010

AbstractA study of blood flow in the anterior tibial muscle was performed in a series of 75 young and middle‐aged diabetics. Only three of the patients had symptoms and signs of peripheral vascular insufficiency in the legs.Peak muscular flow after maximal work during ischaemia was reduced in the diabetic patients and decreased with increasing duration of diabetes.Medial calcification of the arteries was common, and it was possible to demonstrate that the decrease in maximal blood flow with increasing duration of diabetes was associated with the presence of arterial calcification.The latency of peak flow was reduced in the diabetics, as has been previously observed by other authors.
IMMUNOGLOBULINS IN THE COURSE OF VIRAL HEPATITIS AND IN CHOLESTATIC AND OBSTRUCTIVE JAUNDICE
Authors: Wollheim Frank A. 
Published: August 2010

Abstract Immunoglobulins G, A and M were determined during the course of disease in 19 cases of sporadic infectious hepatitis, eight cases of epidemic infectious hepatitis, 11 cases of serum hepatitis, five cases of cholestatic jaundice, and 15 cases of obstructive jaundice. A marked increase was found initially in both infectious hepatitis groups (367% ± 160 and 376% ± 145, respectively), which fell precipitously during the first weeks of illness. Significantly lower γM levels were found in the serum hepatitis group (210% ± 82), and five of the cases showed normal immunoglobulin levels.γG levels rose to a lesser extent (158% ± 54 and 142% ± 36) in the infectious hepatitis patients but tended to remain elevated longer. There was no significant difference between infectious hepatitis and serum hepatitis (131% ± 37). Small but significant increases in γA levels were observed in infectious hepatitis.Slight or no changes occurred in γD levels in three cases of infectious hepatitis and two cases of serum hepatitis. No alterations of immunoglobulin levels were observed in connection with the onset of cholestatic or obstructive jaundice, indicating that liver damage per se does not give rise to the changes observed in viral hepatitis.A close correlation was observed in this material of previously healthy individuals between thymol turbidity and γM (r=0.76).
RIGHT ATRIAL MYXOMA
Authors: Hansen Jørgen Fischer , Lyngborg Kjeld , Andersen Mogens , Wennevold Alf 
Published: August 2010

Abstract A review of the symptomatology of right atrial myxoma is given, based on 33 cases from the literature and on two cases studied by us.This diagnosis should be considered in any patient with isolated right heart failure without pulmonary congestion, pulmonary disease, or pulmonary stenosis.A tricuspid murmur, intermittent cardiac or cerebral symptoms or radiographic demonstration of non‐valvular intracardiac calcifications should increase the suspicion.Selective right atrial angiocardiography is the diagnostic method of choice. The diagnosis cannot be excluded without this examination, which always should be performed in any patient with isolated tricuspid valvular disease.
STUDIES ON FATTY ACID METABOLISM IN DIABETICS DURING EXERCISE
Authors: Carlström Sven 
Published: August 2010

Abstract Male, newly diagnosed diabetics of the juvenile type have been examined with a short exercise test on a bicycle ergometer and the plasma concentration of glycerol was followed. As earlier shown, the exercise induced a greater lipid mobilization in the diabetics in comparison with control subjects studied earlier.The exercise test was then repeated after a period of adequate insulin therapy. At the second examination the diabetics showed a clear tendency to normalization of the plasma glycerol curve, indicating that insulin therapy will decrease the abnormally high exercise‐induced lipid mobilization in diabetes mellitus.
SERUM B12 AND SERUM IRON AFTER GASTRIC SURGERY
Authors: Schrumpf A. , Gjertsen K. 
Published: August 2010

Abstract Immediately after Billroth II one‐third of patients have lost intrinsic factor, most of them permanently. As time goes on there is a steadily rising incidence, 45% lacking intrinsic factor after 18 months. Impaired absorption of labeled vitamin B12 is more frequent after surgery for stomach cancer than in patients with gastric or duodenal ulcer. Loss of intrinsic factor is less pronounced in duodenal than in gastric ulcer.The pattern of serum iron levels gradually becomes similar to that of pernicious anemia after surgery. All patients operated on should be kept under medical observation, so that vitamin B12 and iron can be supplemented at the most favorable time.
DEATHS FROM ASTHMA, WITH SPECIAL REFERENCE TO THE LAST DRUG TREATMENT
Authors: Iisalo E. I. , Iisalo E. U. M. , Tala E. J. 
Published: August 2010

Abstract.Fifty‐four patients who died from asthma in hospital in 1956–1967 were analysed retrogressively, with special reference to the drug therapy immediately before death.Clinically sudden and unexpected death was as common as death which was attributed to asphyxia, but at autopsy (45 patients) mucous bronchial obstruction was established in 37 cases.During the last 24 hours of life, 51 of the patients were given sympathomimetics, 31 of them several sympathomimetics concomitantly and 21 in nebulised form. One of the patients died during an adrenaline injection, and one made liberal use of the orciprenaline aerosol she had brought with her to hospital.The xanthine derivative (glyphylline) was given during the last 24 hours to 50 patients. The glyphylline dose was over 3 g/24 hours in eight cases. The death of seven of them was regarded as clinically sudden and unexpected; at least one patient had manifest symptoms of central nervous system stimulation prior to death. Equally large glyphylline doses, however, were given to the control patients in status asthmaticus who survived.Polypharmacy seems to have been a probable iatrogenic factor influencing the mechanism of death in at least four patients of the total material. Corticosteroids were not administered to four patients who had been managed for the last month prior to hospitalisation with corticosteroids. Other iatrogenic factors influencing the mechanism of death seemed to be technical complications of respirator treatment in two cases and the possibility that respirator therapy was delayed.
REITER'S SYNDROME: A FOLLOW‐UP STUDY
Authors: Sairanen Eero , Paronen Ilmari , Mähönen Heikki 
Published: August 2010

Abstract. During the last war there was an epidemic of dysentery in Finland, on the Karelian Isthmus. Out of a total of about 150,000 cases, Reiter's syndrome developed in 350 (0.2%). A follow‐up study of 100 of these cases was made about twenty years later. The most frequent late changes were rheumatoid spondylitis (32%), chronic arthritis (18%), and iritis (7%). Occasional arthralgia without objective symptoms was also common.After termination of the first stage, 20 patients (20%) had become entirely asymptomatic. The disease resulted in permanent disability in 42 cases (42%). The importance of prostatitis, as a focus of infection in this disease, seems open to doubt. The control study was based on 100 men; examination of the prostate and roentgenography of the sacro‐iliac joints and lumbar spine were performed.
THE PROGNOSIS IN LONG TERM TREATED AND “UNTREATED” ESSENTIAL HYPERTENSION
Authors: Mathisen H. Storm , Löken Halvor , Brox Daniel , Stenbæk Örnulf 
Published: August 2010

Abstract. Since 1955 we have registered patients suffering from essential hypertension. 433 cases, 225 men and 208 women, were graded according to WHO and Hammarström and Bechgaard's system. Medical treatment was started and followed up by one of us (HSM). The numbers of deaths in the treated sample and in an “untreated” series of 290 hypertensive patients are compared with the death rate in the corresponding general population in Norway. The same persons have made the classification of the treated and “untreated” samples.In the treated series the numbers of deaths were 56 men and 29 women instead of the 15.61 men and 12.73 women expected, which shows a death rate of 359% for men and 228% for women. This is far better than of the “untreated” sample, in which the death rates were found to be 985% for men and 813% for women. It seems as if we have succeeded in reducing the death rate to about half by means of medical treatment. There is an appreciable reduction in the number of cerebral deaths in men in the treated sample as compared to the “untreated”. There is not a similar drop in cardiovascular deaths.