bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Mechanism of Banxia Xiexin Decoction in Treating
Gastritis and Diabetes Mellitus through Network Pharmacology and
Molecular Docking Analysis
Authors: Du Yikuan , Chi Xianhong , Chen Qianwen , Xiao Yue , Ma Zhendong , Wang Zhenjie , Guo Zhuoming , Chen Peng , Chen Zilin , Zhang Mengting , Guo Jinyan , Zhou Yuqi , Yang Chun 
Published: April 2024

Background:
Banxia Xiexin decoration (BXD), a complex prescription in Traditional Chinese
Medicine (TCM), clinically acts as a treatment for gastritis and diabetes while its mechanism of
treatment remains unknown.

Objection:
This study aimed to explore the common mechanism of BXD in treating gastritis and
diabetes based on network pharmacology and molecular docking technology.

Methods:
The seven Chinese herbal components and drug targets were collected from the Traditional
Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) for gastritis and
diabetes using GeneCards, DisGeNET, Comparative Toxicogenomics Database (CTD), and Online
Mendelian Inheritance in Man (OMIM) databases. Common drug and disease targets were imported
into the STRING data platform for protein-protein interaction (PPI) analysis, and Cytoscape 3.7.2
software for network topology analysis, and core targets were filtered.

Results:
There were 124 components, 249 targets, 449 targets for gastritis, and 4005 targets for diabetes.
After mapping, 83 BXD targets for gastritis and diabetes were obtained, and the targets with
high correlation were STAT 3, JUN, TNF, IL-6, etc. More relevant targets were involved in the cancer
pathway, AGE-RAGE signaling pathway of diabetic complications, fluid shear stress, and atherosclerosis
pathway.

Conclusion:
This study preliminarily reveals that BXD may play a role in the treatment of gastritis
and diabetes mellitus through multi-components, multi-targets, and multi-pathways, and proposes
some potential "component-target-pathway" hypotheses in light of previous reports.
A Novel Detection of Cerebrovascular Disease using Multimodal Medical Image Fusion
Authors: Paul Sudip , Jain Shruti 
Published: April 2024

Background:
Diseases are medical situations that are allied with specific signs and
symptoms. A disease may be instigated by internal dysfunction or external factors like pathogens.
Cerebrovascular disease can progress from diverse causes, comprising thrombosis, atherosclerosis,
cerebral venous thrombosis, or embolic arterial blood clot.

Objective:
In this paper, authors have proposed a robust framework for the detection of cerebrovascular
diseases employing two different proposals which were validated by use of other datasets.

Methods:
In proposed model 1, the Discrete Fourier transform is used for the fusion of CT and
MR images which was classified them using machine learning techniques and pre-trained models
while in proposed model 2, the cascaded model was proposed. The performance evaluation
parameters like accuracy and losses were evaluated.

Results:
92% accuracy was obtained using Support Vector Machine using Gray Level Difference
Statistics and Shape features with Principal Component Analysis as a feature selection
technique while Inception V3 resulted in 95.6% accuracy while the cascaded model resulted in
96.21% accuracy.

Conclusion:
The cascaded model is later validated on other datasets which results in 0.11% and
0.14% accuracy improvement over TCIA and BRaTS datasets respectively.
Identifying Depression Through Machine Learning Analysis of Omics Data: Scoping Review
Authors: Taylor Brittany , Hobensack Mollie , Niño de Rivera Stephanie , Zhao Yihong , Masterson Creber Ruth , Cato Kenrick 
Published: April 2024

Background
Depression is one of the most common mental disorders that affects >300 million people worldwide. There is a shortage of providers trained in the provision of mental health care, and the nursing workforce is essential in filling this gap. The diagnosis of depression relies heavily on self-reported symptoms and clinical interviews, which are subject to implicit biases. The omics methods, including genomics, transcriptomics, epigenomics, and microbiomics, are novel methods for identifying the biological underpinnings of depression. Machine learning is used to analyze genomic data that includes large, heterogeneous, and multidimensional data sets.

Objective
This scoping review aims to review the existing literature on machine learning methods for omics data analysis to identify individuals with depression, with the goal of providing insight into alternative objective and driven insights into the diagnostic process for depression.

Methods
This scoping review was reported following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. Searches were conducted in 3 databases to identify relevant publications. A total of 3 independent researchers performed screening, and discrepancies were resolved by consensus. Critical appraisal was performed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies.

Results
The screening process identified 15 relevant papers. The omics methods included genomics, transcriptomics, epigenomics, multiomics, and microbiomics, and machine learning methods included random forest, support vector machine, k-nearest neighbor, and artificial neural network.

Conclusions
The findings of this scoping review indicate that the omics methods had similar performance in identifying omics variants associated with depression. All machine learning methods performed well based on their performance metrics. When variants in omics data are associated with an increased risk of depression, the important next step is for clinicians, especially nurses, to assess individuals for symptoms of depression and provide a diagnosis and any necessary treatment.
Changes in the upper airway and its surrounding structures after bimaxillary surgery in patients with cleft-related Class III deformity
Authors: Ho Chung-Yi , Lu Ting-Chen , Hsieh Yuh-Jia , Chang Chun-Shin , Chen Ying-An , Liao Yu-Fang 
Published: April 2024

ABSTRACT

Objectives
To compare upper airway changes following bimaxillary surgery for correction of Class III deformity between patients with unilateral cleft lip and palate (UCLP) and bilateral cleft lip and palate (BCLP) and to compare the preoperative and postoperative upper airway among patients with UCLP and BCLP to healthy controls.

Materials and Methods
Sixty adults with CLP-related skeletal Class III deformity (30 UCLP and 30 BCLP) who consecutively underwent bimaxillary surgery were studied retrospectively. Cone-beam computed tomography (CBCT) was performed before and after surgery to measure upper airway and movements of facial skeletal and surrounding structures. CBCT images from 30 noncleft skeletal Class I adults, matched by age, gender, and body mass index and without surgical intervention, served as controls.

Results
After surgery, the volume of the nasopharynx increased in patients with CLP (both P &lt; .001). Patients with CLP did not differ from controls in postoperative volume of the nasopharynx or oropharynx. However, the nasal cavity differed significantly between patients with CLP and controls (P &lt; .001).

Conclusions
After bimaxillary surgery, the nasal cavity of patients with CLP differed significantly compared with the controls. Volumes of the nasopharynx and oropharynx did not differ between patients with CLP after surgery and controls.
Studi Evaluasi Pembelajaran Daring Gugus V Penebel
Authors: Yanti Kadek Khrisna Purnama , Suniasih Ni Wayan 
Published: April 2024

Pembelajaran daring di Indonesia tergolong baru khususnya di Sekolah Dasar tentu memiliki kelebihan dan kekurangan dalam pelaksanaannya. Banyak terjadi hambatan dalam pelaksanaanya seperti kurang terampilnya guru dan siswa dalam mengoperasikan perangkat pembelajaran daring, kurangnya sarana prasarana penunjang pembelajaran daring. Penelitian ini meneliti permasalahan yaitu bagaimana efektifitas pelaksanaan pembelajaran daring Gugus V Penebel ditinjau dari variabel context, input, process, product. Penelitian ini bertujuan untuk mengetahui efektivitas pelaksanaan pembelajaran daring SD Gugus V Penebel diukur dari variabel context, input, process, product. Penelitian ini termasuk jenis penelitian studi evaluasi. Subjek penelitian adalah guru terdiri dari 31 orang dan 5 kepala sekolah di SD Gugus V Penebel. Data dikumpulkan melalui kuesioner, wawancara dan dokumentasi. Analisis data secara deskriptif kuantitatif dan deskriptif kualitatif. Data dianalisis adalah hasil pengisian kuesioner, menghitung rata-rata skor dan mengkonversikannya ke kategori skala lima, kemudian mengubah skor mentah menjadi Z-Skor. Z-Skor kemudian ditransformasi ke dalam T-Skor kemudian diverifikasi ke dalam kuadran prototype Glickman. Hasil analisis data diperoleh variabel context menghasilkan F(+) lebih besar daripada F(-) yang berarti efektif, arahnya positif (+), variabel input menghasilkan F(+) lebih besar daripada F(-) yang berarti efektif arahnya positif (+), variabel process menghasilkan F(+) sama dengan F(-) yang berarti efektif arahnya positif (+), variabel product menghasilkan F(+) lebih besar dari F(-) yang berarti efektif arahnya positif (+). Setelah diverifikasi ke kuadran Glicman pelaksanaan pembelajaran daring berada di kuadran I yang artinya sangat efektif. Berdasarkan temuan tersebut dapat disimpulkan pelaksanaan pembelajaran daring SD Gugus V Penebel dari variabel context, input, process, product berjalan dengan sangat efektif.
Video Pembelajaran Berbasis Inquiry Learning Pada Muatan IPA Materi Komponen Ekosistem Bagi Siswa Kelas V SD
Authors: Joni Wayan , I Komang Ngurah Wiyasa  , Kt. Ngr. Semara Putra  
Published: April 2024

Pemanfaatan media pembelajaran yang kurang maksimal sehingga siswa sulit memahami materi pembelajaran terutama pada muatan IPA yang berpengaruh terhadap hasil belajar siswa. Tujuan penelitian mengembangkan video pembelajaran berbasis inquiry learning pada muatan IPA materi komponen ekosistem bagi siswa kelas V SD. Jenis penelitian pengembangan menggunakan model pengembangan produk ADDIE (analyse, desain, development, implemtation, evaluation). Subjek dari produk pengembangan video pembelajaran berbasis inquiry learning yaitu 1 ahli media, 1 ahli materi, 1 ahli desain pembelajaran, uji perorangan 3 orang siswa kelas V dan uji coba kelompok kecil 9 orang siswa. Metode pengumpulan data pada penelitian dilakukan melalui metode kuisioner/angket, wawancara. Teknik analisis yang dilakukan dalam penelitian ini adalah teknik analisis statistik deskriptif kualitatif dan statistik deskriptif kuantitatif. Hasil kelayakan produk video pembelajaran dari uji ahli isi mata pelajaran, desain, media, uji coba perorangan dan kelompok kecil mendapatkan hasil secara berturut-turut sebesar 98,07%, 91,66%, 91,66%, 90,73, dan 93,27%. Kualifikasi produk ini berada pada kualifikasi sangat baik. Maka, video pembelajaran berbasis inquiry learning layak dan valid digunakan pada proses pembelajaran. Implikasi dari penelitian ini, media video pembelajaran berbasis inquiry learning dapat menunjang proses pembelajaran sehingga tidak berpatokan dengan buku siswa saja.
Model Pembelajaran Gallery Walk Berbantuan Flash Card Terhadap Kompetensi Pengetahuan PPKn Siswa
Authors: Astuti Putu Nadi , Putra Made , Abadi I. B. Gede Surya 
Published: April 2024

Penggunaan inovasi-inovasi model pembelajaran belum diterapkan secara optimal, hal ini akan berdapak pada kegiatan pembelajaran menjadi monoton sehingga siswa kurang aktif dikelas, maka penelitian ini bertujuan untuk menganalisis pengaruh yang signifikan model pembelajaran gallery walk berbantuan flash card terhadap kompetensi pengetahuan PPKn siswa kelas V SD. Jenis penelitian ini menggunakan desain quasi eksperiment, menggunakan rancangan nonquivalent pretest posttest control group design. Populasi penelitian ini kelas V yang berjumlah 269 siswa. Teknik pengambilan sampel menggunakan teknik cluster random sampling didapatkan ialah, satu SD untuk kelas eksperimen dan satu SD untuk kelas kontrol. Data penelitian ini dikumpulkan dengan instrumen tes objektif bentuk pilihan ganda. Setelah keseluruhan data terkumpul selanjutnya dianalisis menggunakan uji-t. Hasilnya menunjukkan terdapat perbedaan yang signifikan kompetensi pengetahuan PPKn kelompok yang dibelajarkan menggunakan model pembelajaran gallery walk berbantuan flash card dan kelompok yang dibelajarkan menggunakan pembelajaran konvensional pada siswa kelas V SD Negeri Gugus IV Pattimura Tahun Ajaran 2019/2020, dibuktikan dengan diperoleh thitung lebih dari ttabel = 5,98518 lebih dari 2,00 (dk sama dengan 39+38-2 sama dengan 75 dengan taraf signifikansi 5%), serta nilai rata-rata posttest kelompok eksperimen 32,5385 > 30,6842 dari nilai rata-rata kelompok kontrol, maka dapat disimpulkan bahwa terdapat pengaruh yang signifikan model pembelajaran gallery walk berbantuan flash card terhadap kompetensi pengetahuan PPKn siswa Kelas V SD.
Model Pembelajaran Team Games Tournament Bermediakan Question Card Terhadap Hasil Belajar Matematika Siswa Kelas IV
Authors: Putri Trisna Nanda , Arini Ni Wayan , Mahadewi Luh Putu Putrini 
Published: April 2024

Saat proses pembelajaran, siswa jarang melakukan diskusi kelompok yang menyebabkan kurangnya interaksi dan peran siswa secara aktif dalam proses pembelajaran. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran team games tournament bermediakan question card terhadap hasil belajar Matematika siswa. Penelitian ini adalah penelitian eksperimen semu (quasy eksperiment), dengan desain penelitian nonequivalent post-test only control group design. Populasi penelitian ini berjumlah 96 orang. Sampel penelitian ini adalah siswa kelas IV SD sebanyak 22 orang kelompok eksperimen dan 26 orang kelompok kontrol. Sampel ditentukan menggunakan teknik random sampling. Data hasil belajar dikumpulkan menggunakan metode tes dengan instrument tes hasil belajar. Data hasil belajar yang diperoleh dianalisis menggunakan teknik analisis statistik deskriptif dan inferensial (uji-t). Berdasarkan hasil analisis data diperoleh thitung sama dengan 2,62 dan ttabel sama dengan 2,000 untuk db sama dengan 46 pada taraf signifikan 5%. Berdasarkan kriteria pengujian, karena thitung> ttabel maka H0 ditolak dan H1 diterima. Hal ini berarti terdapat pengaruh signifikan siswa yang mengikuti model pembelajaran team games tournament bermediakan question card terhadap hasil belajar Matematika siswa kelas IV di. Rata-rata (mean) kelompok eksperimen yaitu 16,05 lebih besar dari rata-rata (mean) kelompok kontrol yaitu 13,04. Simpulan penelitian bahwa model pembelajaran team games tournament bermediakan question card berpengaruh terhadap hasil belajar Matematika siswa kelas IV SD.
Validation Study to Assess the Concurrent Validity of the Beep Test as a Proxy for Cardiopulmonary Endurance, Using VO2 Max as the Criterion Standard
Authors: Senanayake Sameera Peumal , Dabare Prasangi , Silva Athige Rajith Nelosan , Pushpika Sujani , Maddumage Ridmi 
Published: April 2024

Rowing, characterized as a “velocity-centric sport,” demands high physical and physiological performance. Cardiorespiratory endurance, an integral component of physical fitness, plays a vital role in rowing performance. Optimal physical fitness is essential for injury prevention and success in international competitions. Cardiopulmonary exercise testing (CPET) is the gold standard for assessing maximal oxygen uptake (VO2 max), a crucial indicator of cardiopulmonary endurance. The considerable expense and specialized expertise required for CPET have prompted the utilization of field tests, such as the beep test. The current study aims to validate the accuracy of the beep test in measuring VO2 max uptake as the gold standard. The present cross-sectional observational study involved 16 participants from the national rowing pool of Sri Lanka (11 males, 5 females). The study adhered to the Bruce protocol for implementing CPET to measure VO2 max. Concurrently, the standardized beep test, encompassing 21 progressively challenging levels, was administered to assess the VO2 max of participants. The number of shuttles completed during the beep test underwent meticulous conversion into corresponding VO2 max values, facilitating a comparative analysis with the VO2 max values derived from CPET. Among the key findings, the CPET among Sri Lankan rowers, male rowers exhibited statistically significant disparities across several vital physiological parameters, including VO2 max, VO2 max at anaerobic threshold (VO2 max AT), maximum heart rate (HR max), and minute ventilation (VE), against their female counterparts. A statistically significant and positive correlation was discerned among female rowers between the VO2 max values obtained through the gold standard CPET and those derived from the beep test. However, a consistent trend emerged, revealing that the beep test consistently overestimated VO2 max in both male and female rowers compared to the gold standard CPET method. The study underscores the importance of considering population-specific factors and advocates for developing refined equations to enhance the accuracy of field tests in predicting cardiopulmonary endurance.
Foreign experience of investigating crimes committed by members of youth informal groups (associations)
Authors: Larkin M. A. 
Published: April 2024

The article deals with specific issues of foreign experience in investigating crimes committed by members of informal youth groups (associations). It is emphasized that the study of foreign experience in the investigation of crimes committed by members of youth informal groups (associations) will contribute to the development and improvement of recommendations for the investigation of the corresponding category of criminal offenses in Ukraine.
The peculiarities of detection and investigation of crimes committed by members of youth informal groups (associations) in France, Germany, the Netherlands, Canada and the USA are analyzed.
Most often, French youth can unite in informal groups in connection with a common place of residence (street, district, city), because of race, nationality, political views, social crises, etc. Difficulties in investigating the criminal activities of informal youth in France are associated with the active use of social networks for the preparation and concealment of committed offenses, the organization of gangs, an increase in their number, and a great public outcry.
All youth informal groups (associations) in Germany can be divided into 3 types: 1) associations of young people who are migrants, refugees and spend their free time together, live on the same street, in the same district; 2) neo-Nazi youth associations; 3) unification of youth on the basis of political views and protest sentiments.
The boom in youth crime in the Netherlands occurred in the early 1980s. But a balanced preventive work, starting in 1985, gave results. An active struggle is being waged against youth neo-Nazi groups (associations) on the Internet.
There are 434 youth gangs in Canada with approximately 7,070 members. The greatest concentration of youth gangs in British Columbia, Saskatchewan, Manitoba and Ontario.
In the 50s. XX century. American youth, and students in particular, showed themselves for the first time as an active political force, able to defend their positions on an equal footing with political parties and «adult» public organizations. The youth of that time advocated civil liberties – freedom of speech, organizations, meetings, etc. But informal youth groups in the USA are not only a subcultural phenomenon, but also gangs that actively engage in criminal activities based on the promotion of ideas, views, and lifestyles.
The right of military personnel to defense in the context of the European integration Ukraine
Authors: Popov G. V. 
Published: April 2024

The relevance of the article is because certain aspects of harmonisation of legislation of Ukraine and the European Union member states, which are NATO members, in particular, in terms of ensuring the rights of military personnel to defence within criminal proceedings, require their own separate scientific understanding in the current context.
The article analyses the provisions of the Convention for the Protection of Human Rights and Fundamental Freedoms of 1950, the Agreement between the Parties to the North Atlantic Treaty regarding the Status of their Forces of their Armed Forces, and national legislation of Ukraine.
The author notes that today in Ukraine there is no separate system of military justice and no specialisation of attorneys at the level of law in cases of this category has been introduced. Given that our country is currently facing a full-scale invasion, and the establishment of a military justice system following the example of certain NATO member states requires significant budgetary expenditures, it seems appropriate to introduce mandatory specialisation of lawyers providing legal assistance to military personnel in criminal proceedings.
At the same time, NATO member states do not have a same vision of the need to introduce a separate system of military justice, but the existence of agreed standards of legal protection of our military personnel and military personnel of these countries is one of the integral elements of Ukraine’s membership in the North Atlantic Alliance.
In connection with the above, there is already an urgent need to study and implement the above standards in national legislation, including, inter alia, the consolidation of provisions in the legislation on the specialisation of lawyers providing legal aid in criminal proceedings of this category.