bluuebunny/crossref_metadata_2025_split huggingface dataset:
MOF Films for Microsensor Coatings
Authors: Robinson Alex L. , Allendorf Mark , Stavila Vitalie , Thornberg Steve M. 
Published: September 2011

ABSTRACTMetal organic framework (MOF) materials are a class of hybrid organic-inorganic crystalline materials whose pore structures and chemical properties can be tailored by the selection of component chemical moieties. Many MOFs have extraordinary intrinsic surface areas, capable of adsorbing large quantities of other chemicals, such as volatile organic compounds or moisture. Upon absorption of guest molecules, many MOFs undergo reversible changes in the dimensions of their unit cells. These properties suggest several routes to chemical sensing in which the transduction mechanisms are: 1) the stress induced at an interface between a flexible MOF layer and a static microcantilever fabricated with a built-in piezoresistive stress sensor; 2) the change in the resonant frequency of an oscillating microcantilever induced by mass adsorption; and 3) the change in the resonant frequency of a acoustic sensor, such as a surface acoustic wave (SAW) sensor through changes in mass loading and film moduli. This paper focuses on humidity sensing by SAWs coated with Cu3(BTC)2 (HKUST-1) over a very broad concentration range.Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000.
High Photosensitivity Two-Photon Photoresists for Large Area Surface Microstructuring
Authors: DeVoe Robert J. , Lee Tzu-Chen , Larsen Jeremy K. , Ender David A. , Sahlin Jennifer J. , Sykora Craig R. , Patnaude Cheryl A. , Atkinson Matthew R. , Griffin Michael E. , Gates Brian J. , Redinger David H. 
Published: September 2011

ABSTRACTTwo-Photon initiated polymerization (TPIP) has shown great promise for fabrication of complex micro- and nano-structures. The method has been used to fabricate such structures over small areas (< 1 mm2) because of slow fabrication speeds and resulting long fabrication times. In order for TPIP to reach practical application in a commercial setting fabrication times need to be reduced by orders of magnitude. We report results on a highly photosensitive initiation system for photoresists based on free radical and cationic polymerization, where photosensitivity is increased 102- to 103-fold compared to previously reported photoinitiation systems. Threshold writing speeds are determined for critical exposure conditions, including laser power, type and concentration of photoinitiation system, and photoresist type. Surface roughness, a critical parameter in applications such as optics and microfluidics, for example, is also used to determine threshold writing speed. The utility of the approach is demonstrated by making a cell phone keypad light guide from a microreplication tool fabricated using the highly photosensitive photoresist.
True Atomic Level Imaging of Shaped Nanoparticles Composed of Bismuth, Antimony and Tellurium using Scanning Transmission Electron Microscopy.
Authors: Mott Derrick , Mai Nguyen T. , Sakata Teruyoshi , Koyano Mikio , Higashimine Koichi , Maenosono Shinya 
Published: September 2011

ABSTRACTNanotechnology is an area of research that is highly intriguing because of the novel properties often observed for materials whose sizes are reduced to the nanoscale. However, one of the biggest challenges is understanding the underlying principles that dictate the particles resulting properties. The atomic level structure for nanoparticles is suspected to vary from that for the corresponding bulk materials, however, direct observation of this phenomenon has proven difficult. Until recently only indirect information on the atomic level structure of such materials could be obtained with techniques such as XRD, HR-TEM, XPS, etc… However, recent advances in Transmission Electron Microscopy techniques now allow true atomic scale resolution, leading to definitive confirmation of the atomic structure. Namely, Scanning Transmission Electron Microscopy coupled with a High-angle Annular Dark Field detector (STEM-HAADF) has been demonstrated to be capable of achieving a nominal resolution of 0.8 nm (the JEOL JEM-ARM200F instrument). The ability is highly exciting because it will lead to an enhanced understanding of the relationship between atomic structure of nanoparticles and the resulting novel properties. In our own study, we focus on the analysis of the atomic level structure for nanoparticles composed of bismuth, antimony and tellurium for thermoelectric materials. This area has recently received much interest because of the realization that nanotechnology can be employed to greatly enhance the efficiency (dimensionless figure of merit ZT) of this class of materials. One of the most intriguing parameters leading to the enhanced TE activity is the relationship between composition and structure that exists within individual nanoparticles. We report our results on a study of the atomic level structure for both nanowires and nanodiscs composed of bismuth, antimony and tellurium. It was found that the nanoparticles have a complex structure that cannot be elucidated by conventional techniques such as XRD or HR-TEM. In addition, by employing Energy Dispersive Spectroscopy (EDS), a greater understanding of the composition-structure dependence was gained. The results are primarily discussed in terms of the atomic level resolution images obtained with the STEM-HAADF technique.
Antimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators
Authors: Campbell Eric L. , Serhan Charles N. , Colgan Sean P. 
Published: September 2011

Abstract
Mucosal surfaces function as selectively permeable barriers between the host and the outside world. Given their close proximity to microbial Ags, mucosal surfaces have evolved sophisticated mechanisms for maintaining homeostasis and preventing excessive acute inflammatory reactions. The role attributed to epithelial cells was historically limited to serving as a selective barrier; in recent years, numerous findings implicate an active role of the epithelium with proresolving mediators in the maintenance of immunological equilibrium. In this brief review, we highlight new evidence that the epithelium actively contributes to coordination and resolution of inflammation, principally through the generation of anti-inflammatory and proresolution lipid mediators. These autacoids, derived from ω-6 and ω-3 polyunsaturated fatty acids, are implicated in the initiation, progression, and resolution of acute inflammation and display specific, epithelial-directed actions focused on mucosal homeostasis. We also summarize present knowledge of mechanisms for resolution via regulation of epithelial-derived antimicrobial peptides in response to proresolving lipid mediators.
Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance
Authors: Roumenina Lubka T. , Sène Damien , Radanova Maria , Blouin Jacques , Halbwachs-Mecarelli Lise , Dragon-Durey Marie-Agnes , Fridman Wolf H. , Fremeaux-Bacchi Veronique 
Published: September 2011

Abstract
C1q plays a key role in apoptotic cell and immune complex removal. Its absence contributes to the loss of tolerance toward self structures and development of autoimmunity. C1q deficiencies are extremely rare and are associated with complete lack of C1q or with secretion of surrogate C1q fragments. To our knowledge, we report the first case of a functional C1q abnormality, associated with the presence of a normal C1q molecule. Homozygous GlyB63Ser mutation was found in a patient suffering from lupus with neurologic manifestations and multiple infections. The GlyB63Ser C1q bound to Igs, pentraxins, LPSs, and apoptotic cells, similarly to C1q from healthy donors. However, the interaction of C1r2C1s2 and C1 complex formation was abolished, preventing further complement activation and opsonization by C3. The mutation is located between LysB61 and LysB65 of C1q, suggested to form the C1r binding site. Our data infer that the binding of C1q to apoptotic cells in humans is insufficient to assure self-tolerance. The opsonization capacity of C4 and C3 fragments has to be intact to fight infections and to prevent autoimmunity.
Relativistic Anandan quantum phase in the Lorentz violation background
Authors: Bakke K. , Belich H. , Silva E.O. 
Published: September 2011

AbstractWe study the influence of a classical background based on the violation of the Lorentz symmetry on the relativistic Anandan quantum phase. We show that the choice of the Lorentz symmetry violation background provides an abelian contribution for the relativistic Anandan quantum phase.
Antibody purification from human plasma by metal‐chelated affinity membranes
Authors: Yavuz Handan , Bereli Nilay , Armutçu Canan , Yılmaz Fatma , Denizli Adil 
Published: September 2011

AbstractThe aim of this study is to investigate in detail the feasibility of poly(2‐hydroxyethyl methacrylate‐N‐methacryloyl‐(L)‐histidine methyl ester), PHEMAH membranes for purification of immunoglobulin G (IgG) from human plasma. PHEMAH membranes were prepared by photo‐polymerization technique. Then, Zn2+, Ni2+, Co2+, and Cu2+ ions were chelated directly on the PHEMAH membranes. Elemental analysis assay was performed to determine the nitrogen content and polymerized MAH was calculated as 168.5 μmol/g. The nonspecific IgG adsorption onto the plain PHEMA membranes was negligible (about 0.25 mg/mL). A remarkable increase in the IgG adsorption capacities were achieved from human plasma with PHEMAH membranes (up to 68.4 mg/mL). Further increase was observed with the metal‐chelated PHEMAH membranes (up to 118 mg/mL). The metal‐chelate affinity membranes allowed the one‐step separation of IgG from human plasma. The binding range of metal ions for surface histidines from human plasma followed the order: Cu2+ > Ni2+ > Zn2+ > Co2+. Adsorbed IgG was eluted using 250 mM EDTA with a purity of 94.1%. IgG molecules could be repeatedly adsorbed and eluted with the metal‐chelated PHEMAH membranes without noticeable loss in their IgG adsorption capacity. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Polymerization of 3‐glycidyloxypropyltrimethoxysilane with different catalysts
Authors: Kayan Asgar 
Published: September 2011

AbstractPolymerization reactions of 3‐glycidyloxypropyltrimethoxysilane (GPTS) were carried out by different catalysts, potassium hydroxide, potassium tert‐butoxide, and tetraphenylporphyrin aluminum chloride (TPP–AlCl), and tetrafluorophthalate zironium isopropoxide complex. Polymer samples obtained from the ring‐opening polymerization of GPTS were characterized by Fourier transform infrared spectroscopy, NMR spectroscopy, electrospray ionization mass spectroscopy, and gel permeation chromatography. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
Towards the Synthesis of Massadine: A Unified Strategy for the Stereoselective Synthesis of the Carbocyclic C,D‐Ring Subunit
Authors: Breder Alexander , Chinigo Gary M. , Waltman Andrew W. , Carreira Erick M. 
Published: September 2011

AbstractMassadine is a hexacyclic marine natural product, which belongs to the family of pyrrole–imidazole alkaloids. Herein, we describe a unified approach to the C,D‐ring subunit of this sponge metabolite based on the exploitation of a norbornene scaffold for the stereocontrolled construction of massadine’s carbon skeleton. Highlights of the sequence presented include the application of a stereospecific norbornyl rearrangement for facile introduction of an oxygen at the C7‐position within the norbornene nucleus, a highly regioselective and end group differentiating ozonolytic scission of a CC double bond, and an oxidative decarboxylation reaction for the installation of the hindered secondary C2‐alcohol function. Furthermore, the iterative assembly of the two guanidine entities as well as the implementation of the spirocyclic junction between the C‐ and the D‐rings are described. Collectively, these key transformations permit an entry to an appropriately functionalized carbon framework, which will serve as a starting point for our efforts toward the completion of the synthesis of massadine.
Immobilization and chromatographic evaluation of novel regioselectively substituted amylose‐based chiral packing materials for HPLC
Authors: Shen Jun , Li Pengfei , Liu Shuangyan , Shen Xiande , Okamoto Yoshio 
Published: September 2011

AbstractThe regioselectively substituted amylose derivatives bearing a 4‐tert‐butylbenzoate or 4‐chlorobenzoate group at 2‐position, and 3,5‐dichlorophenylcarbamate and a small amount of 3‐(triethoxysilyl)propylcarbamate groups at 3‐ and 6‐positions were synthesized by a two‐step process based on the esterification of 2‐position of a glucose unit. The obtained derivatives were effectively immobilized onto macroporous silica gel by intermolecular polycondensation of triethoxysilyl groups. Their chiral recognition abilities were evaluated as chiral packing materials (CPMs) for high‐performance liquid chromatography. These CPMs showed high chiral recognition as well as the conventional coated‐type CPM, and can be used with the eluents‐containing chloroform and tetrahydrofuran. With the extended use of these eluents, improvement of chiral recognition and reversed elution orders were realized. For some racemates, the immobilized CPM exhibited ability comparable or better to the commercial immobilized amylose‐ or cellulose‐based columns, Chiralpak IA, IB, and IC. Chirality, 2011. © 2011 Wiley‐Liss, Inc.
Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent
Authors: Mayo Skye C. , Nathan Hari , Cameron John L. , Olino Kelly , Edil Barish H. , Herman Joseph M. , Hirose Kenzo , Schulick Richard D. , Choti Michael A. , Wolfgang Christopher L. , Pawlik Timothy M. 
Published: September 2011

AbstractBACKGROUND:Prognosis after surgery for pancreatic ductal adenocarcinoma (PDAC) is typically reported from the date of surgery. Survival estimates, however, are dynamic and may change based on the time already survived. The authors sought to assess conditional survival among a large cohort of patients who underwent resection of PDAC.METHODS:Between 1970 and 2008, 1822 patients who underwent resection for PDAC with curative intent were identified. Kaplan‐Meier and Cox regression analyses were performed to validate established predictors of survival, and results were compared with 2‐year conditional survival.RESULTS:Actuarial survival was 18% at 5 years, with a median survival of 18 months. Multivariate analysis revealed that tumor size, lymph node ratio, and positive margins were associated with worse survival (all P < .001). Differences in actuarial versus conditional survival estimates were greater the more years already survived by the patient. The 2‐year conditional survival at 3 years—the probability of surviving to postoperative year 5 given that the patient had already survived 3 years—was 66% versus a 5‐year actuarial survival calculated from the time of surgery of 18%. Stratification of 2‐year conditional survival by lymph node ratio and margin status revealed that patients with high lymph node ratio or positive margins saw the greatest increase in 2‐year conditional survival as more time elapsed (both P ≤ .01).CONCLUSIONS:Differences in actuarial versus conditional survival estimates were more pronounced based on the additional years already survived by the patient. Conditional survival may be a helpful tool in counseling patients with PDAC, as it is a more accurate assessment of future survival for those patients who have already survived a certain amount of time. Cancer 2011. © 2011 American Cancer Society.
A Polypyrrole‐Imprinted Electrochemical Sensor Based on Nano‐SnO2/Multiwalled Carbon Nanotubes Film Modified Carbon Electrode for the Determination of Oleanolic Acid
Authors: Zhang Zhaohui , Luo Lijuan , Chen Hongjun , Zhang Minglei , Yang Xiao , Yao Shouzhuo , Li Jiaxing , Peng Mijun 
Published: September 2011

AbstractA sensitive molecularly imprinted electrochemical sensor with specific recognition ability for oleanolic acid was synthesized by modification of multiwalled carbon nanotubes (MWNTs) decorated with tin oxide nanoparticles (nano‐SnO2/MWNTs) and polypyrrole‐imprinted polymer on a carbon electrode. The morphology and electrochemical performance of the imprinted sensor were investigated by using scanning electron microscope (SEM), X‐ray diffraction (XRD), cyclic voltammetry (CV), linear sweep voltammetry (LSV) and amperometric i–t curve. The results showed that the imprinted sensor displayed excellent selectivity toward oleanolic acid. A linear relationship between the response currents and oleanolic acid concentrations ranging from 5.0×10−8 g/L to 2.0×10−5 g/L was obtained for the imprinted sensor. The limit of detection (LOD) of the imprinted sensor toward oleanolic acid was calculated as 8.6×10−9 g/L at a signal to noise ratio (S/N) of 3. This imprinted sensor was successfully applied to the determination of oleanolic acid in Acitinidia deliciosa root samples.
Capillary Electrophoresis Assisted Flow System for In Situ Analysis of Products of Heterogeneous Electrocatalytic and Catalytic Processes: Application to the Oxidation of Glycerol
Authors: Lopes Fernando Silva , Nogueira Thiago , do Lago Claudimir Lucio , Gutz Ivano G. R. 
Published: September 2011

AbstractAnalysis by capillary electrophoresis (CE) of nanoliter samples taken 0.05 mm away from the electrode/solution interface assisted in the evaluation of glycerol electrooxidation on noble metals (Pt, Au and Pd). The fully automated all electrochemical flow system generates a conductometric electropherogram every few minutes, while exploring experimental parameters. Products like glycerate, glycolate, formate and hydroxymalonate were observed in different ratios by changing the electrocatalyst and the applied potential. On Pd, dissolved oxygen oxidizes glycerol at zero current. This new approach holds promise for fast in situ study of reaction products of heterogeneous catalysis reactions and electrode processes in general.
Design of a High Throughput 25‐Well Parallel Electrolyzer for the Accelerated Discovery of CO2 Reduction Catalysts via a Combinatorial Approach
Authors: Dang Tram , Ramsaran Richard , Roy Sayak , Froehlich Jesse , Wang Joseph , Kubiak Clifford P. 
Published: September 2011

AbstractA combinatorial approach is described for screening homogeneous CO2 reduction electrocatalysts by means of a high‐throughput 25‐well parallel electrolyzer. Active catalysts were then screened by three methods: (1) the presence of CO gas in the electrolyzer head space; (2) a pH change for the individual solutions before and after bulk electrolysis due to proton consumption during CO2 reduction; and (3) other physical attributes. Based on these screening methods, two solutions out of the 25 were selected for further study. One out of two selected solutions, nickel cyclam, a well‐known CO2 reduction electrocatalyst, was correctly identified to be the most active.
Comparison of Planar and 3‐D Interdigitated Electrodes as Electrochemical Impedance Biosensors
Authors: Rana Sunil , Page Robin H , McNeil Calum J. 
Published: September 2011

AbstractIt has been reported that the introduction of a dielectric barrier between adjacent digits of an interdigitated electrode array can improve the sensitivity of the array as an electrochemical impedance biosensor. Here we present an in‐depth analysis of the impedance in planar interdigitated electrodes and 3‐D interdigitated electrodes (with dielectric barriers). The analysis indicates that the planar geometry not only provides lower impedance but also a higher change impedance as a result of molecular immobilization on the electrode array surface.
A new perspective on the Dunnett procedure: Filling the gap between NOEC/LOEC and ECx concepts
Authors: Delignette-Muller Marie-Laure , Forfait Carole , Billoir Elise , Charles Sandrine 
Published: September 2011

Abstract
The no-observed-effect concentration (NOEC) is known to be based on a wrong usage of hypothesis tests, and the use of confidence intervals is preferred. The purpose of the present study is to provide an easy and proper way to interpret ecotoxicological tests based on simultaneous confidence intervals associated with the commonly used Dunnett procedure, and to show how these intervals may allow one to infer ECx values (effective concentrations). Environ. Toxicol. Chem. 2011;30:2888–2891. © 2011 SETAC
Modulation of estrogen synthesis through activation of protein kinase A in H295R cells by extracts of estuary sediments
Authors: Huang Chong , Wu Shimin , Zhang Xiaowei , Chang Hong , Zhao Yanbin , Giesy John P , Hu Jianying 
Published: September 2011

Abstract
Sediments from two estuaries within Liaodong Bay, China, were examined for the effects on steroidogenesis using H295R human adrenocortical carcinoma cells. Total extracts (TE) isolated from sediments by Soxhlet extraction were separated into three fractions (F1, F2, and F3) using Florisil columns. After exposing H295R cells to each TE and fractions, the expressions of six steroidogenic genes (cytochrome P450 cholesterol side-chain cleavage [CYP11A], 3β-hydroxysteroid dehydrogenase type 1 [3β-HSD1], 3β-hydroxysteroid dehydrogenase type 2 [3β-HSD2], cytochrome P450 17-hydroxylase/17-20 lyase [CYP17], cytochrome P450 aromatase [CYP19], 17β-hydroxysteroid dehydrogenase [17β-HSD]), and the production of six steroid hormones (progesterone [PGT], 17-hydroxyprogesterone [17-HPT], testosterone [TTR], androstenedione [ADD], estrone [E1], and 17β-estradiol [17β-E2]) were measured. The gene expressions of CYP11A, CYP17, 3β-HSD2, and CYP19, and hormone productions of PGT, 17-HPT, TTR, ADD, E1, and 17β-E2 were significantly increased after exposure to F3 extracts from the Daliao River. In particular, greater concentrations of E1 (up to 48-fold) and 17β-E2 (up to 20-fold), as well as up-regulation of CYP19 gene expression (up to tenfold), were caused by exposure to the F3 fraction from the Daliao River, but not from the Daling River. Insight into the mechanism of action was obtained by use of principal component analysis (PCA), the results of which were consistent with unidentified constituents in F3 from the Daliao River activating the protein kinase A (PKA) pathway. This hypothesis was confirmed by reversal of the effects caused by F3 through a co-exposure of a PKA inhibitor (H89) and F3 extract. The H89 down-regulated CYP19 messenger RNA (mRNA) expression with concomitant lesser production of E1 and 17β-E2 in the co-exposure group, indicating unidentified constituents that could modulate estrogen synthesis, primarily through a mechanism of PKA activation. Environ. Toxicol. Chem. 2011;30:2793–2801. © 2011 SETAC
Does social facilitation affect responses to natural and anthropogenic stressors in the freshwater snail Planorbella trivolvis?
Authors: Plautz Stephanie C , Salice Christopher J 
Published: September 2011

Abstract
Social facilitation is the initiation or increase of a trait, such as stressor tolerance, when in the presence of conspecifics, members of the same species. It has been shown to alter the outcome of toxicity experiments in colonial organisms. We evaluated whether social facilitation would impact responses to stressors in the noncolonial New Mexico ramshorn snail (Planorbella trivolvis) by exposing snails to stressors either singly or in groups of three. Social facilitation did not impact snail responses to malathion but did affect responses to predator cues and temperature stress. Environ. Toxicol. Chem. 2011;30:2883–2887. © 2011 SETAC