bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics of acute myeloid leukaemia patients with a large number of azurophilic granules: A single‐centre retrospective study
Authors: Zhao Shuqi , Wang Jinghan , Lou Yinjun , Huang Xin , Xie Wanzhuo , Yu Wenjuan , Liu Lin , Zhu Yijing , Gao Xiangli , Ma Guanghua , Zhou Ziyang , Ghoushi Ehsan , Ghafouri Mohammadyousof , Jin Jie , Tong Hongyan , Zhou De 
Published: May 2024

SummaryLarge amounts of azurophilic granules are considered to be a morphological feature of acute promyelocytic leukaemia (APL). However, a small percentage of acute myeloid leukaemia (AML) patients also have a large number of azurophilic granules. A large cohort of 3210 AML patients in our hospital was screened to identify AML patients who had a large number of azurophilic granules. The clinical parameters of these patients were collected and compared with typical AML patients (control Group 1) and APL patients (control Group 2). The incidence of AML with a large number of azurophilic granules was 1.26%. The fibrinogen and D‐dimer levels of patients in the study group were more similar to those of patients in control Group 2, as was the incidence of bleeding events. Additionally, patients in the study group had higher FLT3‐ITD and NPM1 mutation rates than patients in control Group 1. Finally, patients in the study group had a higher 30‐day mortality rate than those in control Group 2 (24.2% vs. 9.09%) and showed a higher 30‐day mortality trend than those in control Group 1. Therefore, we should pay more attention to the prevention of coagulation dysfunction and bleeding events for these patients.
A meta‐analysis of coping strategies and psychological distress in rheumatoid arthritis
Authors: Hinch Rebecca , Sirois Fuschia M. 
Published: May 2024

AbstractPurposeTheory and research indicate that coping plays a central role in the experience of psychological distress in people with rheumatoid arthritis (RA). This study meta‐analysed the associations of adaptive and maladaptive coping strategies with psychological distress in people with RA to quantify and better understand the proposed differential relationships, as well as the factors that might influence these links.MethodsSearches of four databases identified eligible studies according to a pre‐registered protocol. Two random effects meta‐analyses examined the direction and magnitude of the links between adaptive coping (problem‐focused and emotional approach coping) and maladaptive coping (emotional avoidance and pre‐occupation coping) and psychological distress (stress, anxiety, and depression). Study quality was evaluated using a bespoke tool. Moderator analyses for sample characteristics and distress type were conducted.ResultsSearches identified 16 eligible studies with 46 effects. Meta‐analysis of maladaptive coping and distress yielded a significant, medium sized association, k = 12, r = .347, 95% CIs [.23, .46]. Moderator analyses were significant only for type of distress, with effects for depression being larger than that for combined distress. Effects did not vary as a function of age, participant sex, or disease duration. Meta‐analysis for adaptive coping was not significant, k = 10, r = −.155, 95% CIs [−.31, .01].ConclusionsFindings from this first meta‐analysis of coping and distress in RA indicate that maladaptive but not adaptive coping is associated with greater distress. Further research is needed to grow the evidence base to verify the current findings especially with respect to adaptive coping.
Fibrillar extracellular matrix produced by pericyte‐like cells facilitates glioma cell dissemination
Authors: Vymola Petr , Garcia‐Borja Elena , Cervenka Jakub , Balaziova Eva , Vymolova Barbora , Veprkova Jana , Vodicka Petr , Skalnikova Helena , Tomas Robert , Netuka David , Busek Petr , Sedo Aleksi 
Published: May 2024

AbstractGliomagenesis induces profound changes in the composition of the extracellular matrix (ECM) of the brain. In this study, we identified a cellular population responsible for the increased deposition of collagen I and fibronectin in glioblastoma. Elevated levels of the fibrillar proteins collagen I and fibronectin were associated with the expression of fibroblast activation protein (FAP), which is predominantly found in pericyte‐like cells in glioblastoma. FAP+ pericyte‐like cells were present in regions rich in collagen I and fibronectin in biopsy material and produced substantially more collagen I and fibronectin in vitro compared to other cell types found in the GBM microenvironment. Using mass spectrometry, we demonstrated that 3D matrices produced by FAP+ pericyte‐like cells are rich in collagen I and fibronectin and contain several basement membrane proteins. This expression pattern differed markedly from glioma cells. Finally, we have shown that ECM produced by FAP+ pericyte‐like cells enhances the migration of glioma cells including glioma stem‐like cells, promotes their adhesion, and activates focal adhesion kinase (FAK) signaling. Taken together, our findings establish FAP+ pericyte‐like cells as crucial producers of a complex ECM rich in collagen I and fibronectin, facilitating the dissemination of glioma cells through FAK activation.
Circular RNA circESYT2 serves as a microRNA‐665 sponge to promote the progression of hepatocellular carcinoma through ENO2
Authors: Du Wei , Li Ying , Wang Xufeng , Xie Sunzhe , Ci Hongfei , Zhou Jiaming , Zhu Ningqi , Chen Zule , Zheng Yan , Jia Huliang 
Published: May 2024

AbstractCircular RNAs (circRNAs) have emerged as crucial regulators in tumor progression, yet their specific role in hepatocellular carcinoma (HCC) remains largely uncharacterized. In this study, we utilized high‐transcriptome sequencing to identify the upregulation of circESYT2 (hsa_circ_002142) in HCC tissues. Functional experiments carried out in vivo and in vitro revealed that circESYT2 played a significant role in maintaining the growth and metastatic behaviors of HCC. Through integrative analysis, we identified enolase 2 (ENO2) as a potential target regulated by circESYT2 through the competitive endogenous RNA sponge mechanism. Additional gain‐ or loss‐of‐function experiments indicated that overexpression of circESYT2 led to a tumor‐promoting effect, which could be reversed by transfection of microRNA‐665 (miR‐665) mimic or ENO2 knockdown in HCC cells. Furthermore, the direct interaction between miR‐665 and circESYT2 and between miR‐665 and ENO2 was confirmed using RNA immunoprecipitation, FISH, RNA pull‐down, and dual‐luciferase reporter assays, highlighting the involvement of the circESYT2/miR‐665/ENO2 axis in promoting HCC progression. These findings shed light on the molecular characteristics of circESYT2 in HCC tissues and suggest its potential as a biomarker or therapeutic target for HCC treatment.
Cross‐cultural translation and validation of the Chinese version Distress Tolerance Scale for adolescents with chronic physical disease
Authors: Lee Shu‐Li , Wu Li‐Min , Lin Shu‐Yuan , Chen Tzu‐Han , Lin Wei‐Ting 
Published: May 2024

AbstractIntroductionChronic physical disease (CPD) makes life filled with many negative events in adolescents, but not all adolescents experiencing negative life events proceed to develop emotional distress, only those with low emotional distress tolerance (EDT). A valid and reliable scale to measure EDT in CPD adolescents is important for caring for their emotional distress. Therefore, the purpose of this study is to translate the 15‐item English version Distress Tolerance Scale (DTS) into a Chinese version and then validate the scale for measuring EDT of adolescents with CPD.MethodsThe 15‐item English version DTS was translated into a Chinese version using the translation guidelines for cross‐cultural research. Two cohorts of adolescents with CPD were recruited from four hospitals in southern Taiwan, with the first cohort including 124 adolescents with CPD employed to conduct exploratory factor analysis, corrected item‐total correlation and reliability testing, while the second cohort, consisting of 238 adolescents with CPD, was utilized to examine confirmatory factor analysis and concurrent validity.ResultsThe two‐factor nine‐item Chinese version DTS for Adolescents with CPD (C‐DTS‐A) was developed. Lower scores of the C‐DTS‐A were significantly associated with higher diabetes distress, poorer self‐management, and worse glycaemic control; their correlation coefficients sequentially were −.40, .17 and −.23. Cronbach's α and the test–retest reliability of the two‐factor C‐DTS‐A ranged from .81 to .87 and from .79 to .89, respectively.ConclusionThe two‐factor nine‐item C‐DTS‐A with good cross‐cultural translation quality was a reliable and valid scale to assess EDT for adolescents with CPD.
Method myopia
Authors: Ker Alan P. 
Published: May 2024

AbstractMethod myopia is defined as theoretical rhetoric absent empirical discernment regarding flavor‐of‐the‐day econometric methodologies. This Fellows Address discusses why method myopia is pervasive, what factors contribute to the pervasiveness, why is likely it to increase, and finally, a possible remedy. To that end, incentive structures facing researchers, reviewers, and editors are considered within the life‐cycle of a typical econometric methodology. Considering our discipline is empirically driven, there are potentially large costs by using flavor‐of‐the‐day methodologies when an alternative ‐‐ possibly leading to different economic results and policy responses ‐‐ is the appropriate method. Furthermore, method myopia can notably restrict the set of research problems examined thereby creating additional, potentially large, opportunity costs. Finally, over‐selling the superiority/completeness/correctness of results from such flavor‐of‐the‐day methodologies to policy makers can not only be costly in the particular case, but can undermine the long‐term credibility of our disciplinary advice to policy makers.
Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives
Authors: Liu Jiyuan , Yang Fan , Hu Jinqu , Zhang Xiuchun 
Published: May 2024

AbstractGliomas are the most common primary tumors of the central nervous system, with glioblastoma multiforme (GBM) having the highest incidence, and their therapeutic efficacy depends primarily on the extent of surgical resection and the efficacy of postoperative chemotherapy. The role of the intracranial blood–brain barrier and the occurrence of the drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited the efficacy of chemotherapeutic agents in patients with GBM and made it difficult to achieve the expected clinical response. In recent years, the rapid development of nanotechnology has brought new hope for the treatment of tumors. Nanoparticles (NPs) have shown great potential in tumor therapy due to their unique properties such as light, heat, electromagnetic effects, and passive targeting. Furthermore, NPs can effectively load chemotherapeutic drugs, significantly reduce the side effects of chemotherapeutic drugs, and improve chemotherapeutic efficacy, showing great potential in the chemotherapy of glioma. In this article, we reviewed the mechanisms of glioma drug resistance, the physicochemical properties of NPs, and recent advances in NPs in glioma chemotherapy resistance. We aimed to provide new perspectives on the clinical treatment of glioma.
Practical training using BEWE aimed at improving the diagnosis ability of erosive tooth wear for dental students—A randomized trial
Authors: Leone Camilla Cristina Lira Di , Bueno Gabriela Carvalho , Boteon Ana Paula , Martins Daiana da Silva , Cruvinel Thiago , Honório Heitor Marques , Wang Linda , Braga Mariana Minatel , Rios Daniela 
Published: May 2024

AbstractIntroductionErosive tooth wear (ETW) has been gaining attention due to its high prevalence. However, ETW clinical diagnosis is difficult and may go unnoticed by many professionals. The present study aimed to develop, implement and evaluate a theoretical–practical training using active methodologies in the development of undergraduate students' skills for the diagnosis of ETW compared to the traditional teaching method.Materials and MethodsThis randomized controlled study involved two parallel groups: control group (n = 22), with learning based only on theoretical content and test group (n = 24), learning by theoretical–practical activity mediated by monitors/tutors. The theoretical class covered the current concepts of ETW, aetiology, diagnosis, use of the BEWE index, prevention and treatment. The practical training included exercises and discussions based on the diagnosis using BEWE scores of a collection of images and extracted teeth. To evaluate the efficacy of the teaching–learning methods, a theoretical multiple‐choice questionnaire and a practical test using images and extracted teeth were applied. The outcome was the number of correct answers. Groups were compared by Mann–Whitney (theoretical knowledge) and T tests (practical ability in diagnosis) (p < .05).ResultsThere was no significant difference between groups in the theoretical evaluation (p = .866). The test group showed higher ability to diagnose ETW lesions compared to the control group in the practical tests (p = .001). The performance of ETW diagnosis was similar when images were used in comparison to extracted teeth (p = .570).ConclusionThe practical activity associated with theoretical classes can be a promising strategy to improve the development of undergraduate students' skills in the diagnosis of ETW.
Ecumenical Formation in the Context of World Christianity
Authors: Simon Benjamin 
Published: May 2024

AbstractThis article sets out the background to and the significance of the Global Ecumenical Theological Institute (GETI), an educational course for younger and emerging theologians, first organized by the World Council of Churches (WCC) to coincide with its 10th Assembly in Seoul, South Korea, in 2013. Further GETIs have taken place since then, most recently at the WCC's 11th Assembly in Karlsruhe, Germany, in 2022. The article finishes by setting out five statements about ecumenical education and formation.
Fabrication and characterization of rubidium ferrites by the solution‐based combustion method using diverse organic fuels
Authors: Gupta Manik , Kumar Ashok 
Published: May 2024

AbstractIn this study, an effort was made to compare the impact of diverse organic fuels on structural and magnetic properties of the pure rubidium ferrites. A novel solution‐based combustion method was proposed that offered simplicity, cost effectiveness, and scalability. Pure rubidium ferrite (RbFeO2) was prepared by using diverse organic fuels such as urea, ethylene glycol (EG), and oxalyl dihydrazide (ODH) to facilitate exothermic reaction for homogeneous product. It was then characterized by different physico‐chemical techniques like X‐ray diffraction (XRD), transmission electron spectroscopy (TEM), Mössbauer spectroscopy, and vibrating sample magnetometer (VSM). Findings revealed that the choice of fuel significantly influenced the particle size and magnetic properties of the product. X‐ray diffraction patterns showed the formation of homogeneous nano‐powder confirmed by TEM analysis. TEM image analysis revealed that the average particle size of the final product obtained was 18 nm for EG, 80 nm for urea, and 40 nm for ODH, respectively. Saturation magnetization values were comparable to lithium ferrites reported in the literature. Mössbauer studies indicated that sample prepared by using EG has better magnetic properties for the application as soft magnetic devices.
Pseudo‐NRBC in the Mindray BC‐6800Plus analyzer: A clue for diagnostic anticipation of fungemia. Experimental and preliminary clinical reports
Authors: Zheng Xiaohe , La Gioia Antonio , Fiorini Fabiana , Wang Dong , Zhang Shihong , Marsano Miriam , Nicastro Carmine , Fumi Maurizio , Luo Jinzhu 
Published: May 2024

AbstractIntroductionCandidemia can be a significant cause of death in immunosuppressed or debilitated patients particularly. Abnormalities of the instrumental cytograms of some hematological analyzers, such as Mindray BC‐6800Plus, can be related to circulating Candida. We studied the possible diagnostic usefulness of this information.MethodsA fungal bloodstream infection has been simulated by adding aliquots of Candida albicans, Candida parapsilosis, and Candida glabrata to 75 leftovers and anonymized peripheral blood samples. Cytographic abnormalities like those of experimental samples were used to select patients with possible fungemia. The microscopic review of peripheral blood smears constituted the confirmatory method.ResultsIn all experimental samples, the various Candida types caused pseudo‐NRBC and morphological abnormalities of WNB and DIFF cytograms. Circulating blastospores, free or engulfed by neutrophils, were the microscopic findings in the peripheral blood smears.In the clinical verification, 72 patients were recruited based on the presence of an evocative cluster in the WNB and DIFF cytograms. The microscopic review of 39 out of 72 samples was positive for NRBC. According to blood cultures, light microscopy revealed fungal forms of several Candida or non‐Candida types in the remaining 33 samples. Nine of these cases were not yet known to suffer from bloodstream infection.ConclusionsAlthough further confirmatory clinical studies are required for these diagnostic abilities, the BC 6800Plus cytographic abnormalities related to fungemia have proven helpful in rapidly monitoring persistent fungemia in already diagnosed patients. In unknown or undiagnosed cases, they could be the trigger point for the subsequent diagnostic‐therapeutic pathway.
A trainee's perspective on scientific conferences
Authors: Valbon Stefanie F , de Carvalho Oliveira Vanessa , Short Lauralie 
Published: May 2024

AbstractAttending and presenting at conferences is a preeminent experience during scientific training. This article provides a trainee's perspective on strategies to promote trainee growth before, during and after scientific meetings, taking the initiatives implemented by the Canadian Society for Immunology (CSI) as an example. A foremost action was the establishment of the Trainee Engagement Committee (TEC) in 2020. The TEC members contribute to the annual symposia by participating in the local organizing committee meetings and organizing trainee‐directed events. We propose actions that conference organizers can take to foster the development of the next generation of scientists. In addition, we offer advice to conference presenters on how to craft talks with trainees in mind and to attendees on how to maximize the quality and longevity of conference interactions. We hope this opinion piece evokes reflections and discussions among scientific societies, organizing committees, conference presenters and trainees alike.
Implementation and use of the Safewards model in healthcare services: A scoping review
Authors: Ward‐Stockham Kristel , Daniel Catherine , Bujalka Helena , Jarden Rebecca J. , Yap Celene Y. L. , Cochrane Lindy , Gerdtz Marie Frances 
Published: May 2024

AbstractSafewards is a multi‐intervention mental health nursing model of practice improvement aimed at preventing and reducing conflict and containment. The use of Safewards has now extended beyond mental health settings. Implementation of Safewards has been reported to be challenging and therefore requires an evidence‐informed and structured approach. This review's objectives were to: (i) Comprehensively map approaches used to implement Safewards interventions; (ii) Characterise the outcomes measured in Safewards implementation studies; and (iii) Identify the facilitators and barriers to Safewards training and its implementation in practice. All quantitative, qualitative and mixed‐methods publications of Safewards, the interventions, evaluations, barriers and facilitators from all healthcare services internationally were included. The Joanna Briggs Institute scoping review and Preferred Reporting Items for Systematic Reviews and Meta‐Analysis extension for Scoping Reviews were used to guide methodology. Data were reported according to the 12 items of the TIDieR. Twenty‐seven publications reported the implementation of Safewards. Descriptions were limited for reporting items such as intervention descriptions, materials, resources, specific procedures and processes, modifications made to interventions and delivery of interventions and training. No consistent theoretical implementation framework was reported. Collaboration, leadership, feedback and co‐design were strong drivers for staff buy‐in, engagement and success for implementation in mental health and acute settings. Transparency, replicability and generalisation require a detailed description of all elements of an intervention being implemented. Without adequate information, only assumptions can be drawn about the clinical governance and process of the implementation and training, and it is difficult to conclude when attempting to replicate the interventions.
Exercise interventions for the effect of endothelial function in hypertensive patients: A systematic review and meta‐analysis
Authors: Liang Chao , Song Zhenpeng , Yao XiaoZhi , Xiao Qian , Fu Hehui , Tang Lixu 
Published: May 2024

AbstractEndothelial dysfunction is crucial factor to the hypertension occurrence, and controversy remains regarding the effect of exercise on improving endothelial function in hypertensive patients. The authors used meta‐analysis to evaluate the intervention effect of exercise on endothelial function in hypertensive patients and to investigate exercise protocols that may have a greater intervention effect. A total of 37 studies and a total of 2801 participants were included. The results were as follows: endogenous nitric oxide (NO)[SMD = .89, 95% CI (.48, 1.30), p < .0001], endothelin‐1 (ET‐1): [SMD = −.94, 95% CI (−1.15, −.73), p <. 0001], flow‐mediated dilation (FMD) [SMD = −.57, 95% CI (.36, .79), p < .000001]. In subgroup analysis, high‐intensity aerobic exercise, with a single exercise duration of 35–50 min, 3–4 times/week for a total of 10–12 weeks, had the largest amount of intervention effect on NO, and moderate‐intensity resistance exercise, with a single exercise duration of ≥60 min, 6 times/week for a total of 15–18 weeks, had the largest amount of intervention effect on ET‐1. In conclusion, exercise can improve NO levels, FDM levels, and reduce ET‐1 secretion of hypertension patients, thereby improve their endothelial function. The ideal intervention effect of improving NO level was more likely to be obtained by taking the exercise prescription of high‐intensity aerobic exercise with a single exercise duration of 35–50 min, 3–4 times/week for 10–12 weeks; the ideal intervention effect of improving ET‐1 was more likely to be obtained by taking the exercise prescription of oderate ‐intensity resistance exercise with a single exercise duration of ≥60 min, 6 times/week for 15–18 weeks.