bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uso de la realidad aumentada, la realidad virtual y la inteligencia artificial en educación secundaria: una revisión sistemática
Authors: Lancheros-Bohorquez Wilson Ferney , Vesga-Bravo Grace Judith 
Published: May 2024

El objetivo de esta revisión sistemática es obtener información frente a la implementación de tecnologías disruptivas (TD) como la realidad aumentada (AR), la realidad virtual (VR) y la inteligencia artificial (IA) en educación secundaria. Al aplicar el protocolo prisma (2021) en las bases de datos Scopus y Taylor & Francis, se obtienen 53 documentos. Los hallazgos giran en torno a tres aspectos. Análisis bibliométrico por año y país, implementación de la AR,VR o IA y resultados obtenidos en los diversos campos del conocimiento impactados por las TD. Las intervenciones con estas tecnologías muestran una creciente tendencia en implementar la AR. La eficacia de la implementación de la AR,VR o IA generó mejoras cognitivas, emocionales y en el proceso enseñanza aprendizaje. Por otra parte, se recomienda profundizar la investigación de implementación de estas TD e integrar en los estudios las combinaciones entre tecnologías.
Dominance hierarchy limits resilience in the endangered queenless ant Dinoponera lucida
Authors: Vieira Maria Eduarda Lima , Tavares Daniel , Muniz Thalles , Chaline Nicolas 
Published: May 2024

Abstract

Division of labour is an important factor of social insect ecological success. However, species differ widely in the specific mechanisms associated with division of labour. Often, social groups have to cope with severe perturbations and resume normal functioning as quickly as possible. How well they do so depends on the behavioural mechanisms involved and on species life-history traits. Here, we studied the division of labour in D. lucida, a threatened species of native Brazilian queenless ants with small colony sizes, to assess whether colonies facing a drastic perturbation of the established task allocation are resilient, and through which potential mechanisms. We first separated the colonies into two sub-colonies, one with the foragers and the other with the nurses. As this is an important modification of colony structure, we expected workers to respond quickly by switching tasks. Our experiment showed that, contrary to our hypotheses, workers showed little plasticity in switching tasks, and colonies did show very limited resilience. Foragers, when isolated from nurses, show a certain plasticity in their behavioural repertoire, performing both tasks (foraging and nursing). However, groups of nurses facing the absence of foragers kept almost exclusively to nursing tasks. Only a few performed episodic outside activities. When workers were returned to their original colonies, foragers switched back to foraging. However, the effect of the manipulation could still be observed 20 days after reintroduction, with workers showing lower general activity, ingesting larvae and reproductive workers losing their dominance. Considering our current knowledge about the regulation of both division of labour and reproductive hierarchies in Dinoponera and other ponerine ants, we propose that this lack of resilience is due to the reproductive conflict between nurses, which delays behavioural maturation and motivation to engage in outside tasks. The existence of individual strategies thus imposes severe costs on group functioning. This could be an additional issue when considering the conservation of this endangered species.
scRNA-seq and spatial transcriptomics reveal neuroendocrine-like cancer cells promote angiogenesis and EMT through neural signaling pathways in male breast cancer
Authors: Zhang xiuli , Sh Yuan , Cai Shouliang , Xu Baoku , Wang Haibo , Cui Jian , Yang Zitong , Chen Siyi , Zhou Zhangjian , Cai Yifan , Zhang Yu , Zhu Liling , Wang Jiandong , Shuqun Zhang 
Published: May 2024

Abstract

Male breast cancer (MBC) is a relatively rare and inadequately researched disease, and its cellular and molecular traits remain obscure. In this study, we conducted single-cell sequencing (N=20) and spatial transcriptomics (N=14) on 34 fresh tissue samples from 27 MBC patients. We identified six major cancer cell subtypes that are associated with the development and progression of MBC. Specifically, cancer cells exhibiting neuroendocrine-like properties facilitate immune evasion, tumor angiogenesis, epithelial-to-mesenchymal transition, cell proliferation, tumor invasion, and metastasis. They do so by secreting neuro-related factors and engaging in regulating neuro-related signaling pathways, synergistically interacting with T cells, macrophages, and fibroblasts within the tumor microenvironment. Additionally, we found that mutations or copy number variations amplifications of the UTY gene on the Y chromosome and/or its high transcript expression are closely associated with adverse clinical outcomes in male cancer patients, including MBC patients. In conclusion, our study provides important data support for a deeper understanding of the molecular characteristics and tumor microenvironment of MBC, and offers important clues for developing improved therapeutic strategies to improve the prognosis of MBC patients.
Robotic-assisted Total Hip Arthroplasty Utilizing a Fluoroscopy-guided System Produced Similar Cup Accuracy and Precision Relative to a Computerized Tomography-based Robotic Platform
Authors: Ong Christian B. , Buchan Graham B.J. , II Christian J. Hecht , Kanaji Arihiko , Kendoff Daniel O. , Kamath Atul F. 
Published: May 2024

Abstract

Introduction: Robotic assistance for total hip arthroplasty (THA) has been demonstrated to improve accuracy of acetabular cup placement relative to manual, unassisted technique. The purpose of this investigation was to compare the accuracy and precision between a fluoroscopy-based robotic total hip arthroplasty platform (FL-RTHA) and a computerized tomography-based (CT-RTHA) platform.
Methods: The study included 98 consecutive FL-RTHA and 159 CT-RTHA procedures performed via direct anterior approach (DAA). All cases were performed for a pre-operative diagnosis of osteoarthritis, avascular necrosis, or rheumatoid arthritis. Primary outcome variables included cup implantation accuracy and precision (variance). Implantation accuracy was calculated as the absolute value of the difference between pre-operative target cup angles (inclination and anteversion) and the same post-operative angles. Percentage placement in the Lewinnek safe zone was also measured for both cohorts.
Results: The FL-RTHA and CT-RTHA cohorts demonstrated a 1.2° difference in absolute values for cup inclination accuracy (4.6° ± 3.6 vs. 3.4 ± 2.7; p=0.005), and no difference in absolute values for cup anteversion accuracy (4.7° ± 4.1 vs. 4.6 ± 3.4; p=0.991). Cohorts demonstrated similar precision for cup inclination and anteversion placement parameters, as well as equivalent Lewinnek safe zone placement.
Conclusions: The use of a fluoroscopy-based robotic assistance platform for primary DAA THA resulted in similar accuracy and precision of acetabular cup placement when compared to a CT-based robotic assistance system.
Diversity, Evenness, &amp; Richness of Wild Mammals of Sutlej River, Punjab, Pakistan
Authors: Sial Muhammad Amir 
Published: May 2024

Abstract

The field surveys were conducted at the following three different water heads, i.e., Sulamnki, Islam, and Panjnad, of the Sutlej River from June 2021 to November 2021, and this is the first effort to estimate the diversity and assess the current threats to the mammalian fauna of the Sutlej River. During the surveys of the research areas, a total of 266 individuals belonging to four orders, seven families, and 12 different species were observed. According to the results, greatest number of individuals of the Rodentia order and the Muridae family, and lowest number of individuals in the Lagomorpha order and the Leporidae family. According to the indices, the Panjnad waterhead showed the greatest diersty and evenness, followed by those of Sulamanki and Islam, with H = 2.453746 and E = 1.065648, H = 2.200177 and E = 0.955525, and H = 2.136116 and E = 0.927703, respectively. The richness of mammals was the same at all three localities (R = 1.61189). Throughout the investigation, some threats, such as pollution, destruction of habitat and the Humen–Wildlif conflict, were observed to drastically affect mammalian diversity.
Methadone versus other opioids for refractory malignant bone pain: a pilot randomised controlled study
Authors: Sulistio Merlina , Gorelik alexandra , Tee Hoong Jiun , Wojnar Robert , Kissane David , Michael Natasha 
Published: May 2024

Abstract

Purpose
Refractory cancer-induced bone pain (CIBP) affects a patient’s functional capacity and quality of life, but there is limited evidence to guide opioid choice. We assessed the feasibility, tolerability, and possible efficacy of methadone rotation (MR) compared to other opioid rotations (OOR) in this cohort.
Methods
Adults with CIBP and worst pain intensity ≥ 4/10 and/or opioid toxicity graded ≥ 2 on the Common Terminology Criteria for Adverse Events were randomised 1:1 to methadone or another opioid rotation. Standardised assessment tools were used at pre-defined study time points up to fourteen days.
Results
From 51 eligible participants, 38 (74.5%) consented, and 29 (76.3%, MR: 14, OOR: 15) completed the fourteen days follow up post opioid rotation. Both groups displayed significant reduction in average (MR: d= -1.2, p = 0.003, OOR: d= -0.8, p = 0.015) and worst pain (MR: d= -0.9, p = 0.042, OOR: d= -0.6, p = 0.048), and total pain interference score (MR: d=-1.1, p = 0.042, OOR: d=-0.7, p = 0.007). Oral morphine equivalent daily dose reduced significantly in MR compared to OOR group (d= -0.8, p = 0.05). The incidence of opioid related adverse event following MR was unchanged but lower in the OOR group (d = 0.9, 95% CI 0.1,1.7, p = 0.022). There was no within group or between group differences in satisfaction with analgesia at the end of the study.
Conclusion
This pilot study demonstrated that MR and OOR in patients with refractory CIBP are feasible, safe, and acceptable to patients. Appropriately powered multi-centre randomised controlled studies are needed to confirm the efficacy of MR and OOR in this cohort.
Trial registration number
ACTRN12621000141842 registered 11 February 2021.
Characterization of Microbial Cellulose Generated in Fermented Moringa and Coated with Flaxseed Mucilage
Authors: Hernández-Rodríguez Juan Pablo , Márquez-Reyes Julia Mariana , Aguirre-Loredo Rocío Yaneli , Rodríguez-Romero Beatriz Adriana , Treviño-Garza Mayra Zulema 
Published: May 2024

Abstract

The fermentation of kombucha using moringa stalk infusion produced microbial cellulose discs (185 g/L) coated with flaxseed mucilage. This study carried out a physical, chemical, and antimicrobial characterization of the discs, both coated (RCD) and not coated (NCD) with flaxseed mucilage. Physical characterization indicated increased opacity, shielding, thickness, and color analysis when coated with flaxseed mucilage. Infrared spectroscopy (FTIR) and X-ray diffraction (XRD) confirmed the crystallinity of the cellulose (94%). Chemical analysis evaluated the antioxidant capacity using DPPH, ABTS, and FRAP tests and found no differences in activity between the discs. Antimicrobial activity differed between treatments against pathogens. NCDs inhibited the growth of E. coli and S. aureus, while RCDs inhibited Salmonella species. The results suggest that cellulose formed during the fermentation of kombucha with moringa stems can have various applications due to its antioxidant and antimicrobial activity.
Deciphering the Role of the PAI_1-mBDNF Pathway in Alcohol Use Disorder: Insights into Pathogenesis and Abstinence Treatment Efficacy
Authors: Liu Shouqing , Xie Xin’e , Zhao Dandan , Jin Nini , Hu Yongwei , Wang Weiping , Luo Xiaodong , Li Gang , Yang Zhirong 
Published: May 2024

Abstract

The pathway of plasminogen activator inhibitor-1 (PAI_1) -brain-derived neurotrophic factor (BDNF) plays a pivotal role in the conversion of Probrain-derived neurotrophic factor (ProBDNF) to mature BDNF (mBDNF), yet its clinical relevance in patients with alcohol use disorder remains understudied (AUD). Enzyme-linked immunosorbent assay (ELISA) was applied to examine the relevant protein levels of the PAI_1-mBDNF pathway in plasma samples from three groups of subjects, and statistical analysis was performed using ANOVA and One-Way Repeated Measures ANOVA. Our findings unveil significant alterations induced by alcohol consumption: (1) A marked decrease in tissue plasminogen activator (tPA), mBDNF, and tropomyosin receptor kinase B (TrkB), while significantly increasing the levels of PAI_1, ProBDNF, and P75 neurotrophin receptor (P75NTR), and inhibiting the conversion of ProBDNF to mBDNF. (2) Following abstinence treatment, the levels of tPA, mBDNF, and TrkB in the AUD group significantly increased, while the levels of PAI_1, ProBDNF, and P75NTR significantly decreased, promoting the conversion of ProBDNF to mBDNF. These clinical research outcomes collectively suggest that alcohol suppresses that alcohol inhibits the conversion of ProBDNF to mBDNF, while the generation of mBDNF significantly increases after abstinence treatment. The PAI_1-mBDNF cleavage pathway may be associated with alcohol use disorder and abstinence treatment.
Salinity inhibits the induction of physiological responses to Fe and K deficiency in two phylogenetically related species: Arabidopsis thaliana (glycophyte) and Cakile maritima (halophyte)
Authors: Houmani Hayet , Alcántara Esteban , Romera Francisco J. , García María J. , Pérez-Vicente Rafael , Abdelly Chedly , Lucena Carlos 
Published: May 2024

Abstract

Aims
Potassium (K) and iron (Fe) deficiency impedes plant growth and development. Because of the increase in soil salinization, plant challenges with nutrient availability are arisen. Thus, understanding the effect of salinity on the mechanisms involved in macro and microelement uptake is crucial.
Methods
Two kinds of experiments were used to study the interactive effect of salinity with K or Fe deficiency. In the first one, Cakile. maritima was subjected to the treatments for a longer period while in the second one, C. maritima and Arabidopsis. thaliana were subjected to similar treatments but for a shorter period.
Results
Long-term responses to salinity and their interaction with K or Fe deficiency reduced shoot and root growth, chlorophyll content, generated an imbalance in nutrient status. Both deficiencies increased root ethylene production. A stimulation of ferric chelate reductase (FCR) activity was also recorded in Fe deficient plants. Salinity increased Na+ concentration notably in shoots, disturbs plant nutrient homeostasis, inhibits root hair proliferation and abolished the induction of FCR activity and ethylene synthesis either by K or Fe shortage. Similar results were obtained in C. maritima and A. thaliana once treatments were imposed during a shorter period with the halophyte being more tolerant. In A. thaliana, the mechanisms involved in K and Fe uptake were inhibited by high salinity.
Conclusion
Salinity inhibits the induction of several physiological and biochemical responses either by K or Fe deficiency by abolishing the main mechanisms involved in the uptake of both elements.
Acute neuromyelitis optica spectrum disorder patients' clinical analysis of disability-related biomarkers
Authors: Zheng Xingyue , Yan Hongjing , Yin Hao , Shi Jing , Liu Yuanyuan , Zhao Haotian , Li Yuzhi , Liu Huakun , Zhang Lei , Yan Zhongrui , Dong Chunbo 
Published: May 2024

Abstract

Background: The clinical features of neuromyelitis optica spectrum disorder (NMOSD) predominantly include optic neuritis and myelitis, among other symptoms. A greater level of disability during the acute phase typically suggests an unfavorable prognosis. Nevertheless, the clinical biomarkers that impact the severity of disability in NMOSD remain unclear.
Methods:We analyzed 41 NMOSD patients and 41 normal controls to identify biomarkers associated with the disease. NMOSD patients were categorized into two groups based on their Expanded Disability Status Scale(EDSS) score: mild to moderate disability (EDSS <4) and severe disability (EDSS ≥4). Correlation and ROC analyses were conducted on various biomarkers, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio(MLR), cerebrospinal fluid (CSF)/serum albumin quotient(QAlb), CSF/blood immunoglobulin G quotient (QIgG), CSF/blood immunoglobulin A quotient (QIgA), CSF/blood immunoglobulin M quotient (QIgM), to identify markers linked to disability severity and confirm their independence.
Results: 1. Significant differences in blood NLR, PLR, and MLR were found between NMOSD patients and normal controls (P<0.01) in biomarker comparison analysis. 2. Significant variations in QAlb, QIgG, QIgA, QIgM, and PLR were noted between the two groups of NMOSD patients stratified by disability severity. 3. A correlation analysis revealed a positive association between QAlb, QIgG, QIgA, QIgM, PLR, and EDSS scores. 4. Levels of QAlb, QIgG, QIgA, QIgM, and PLR were found to be effective indicators of NMOSD severity in Receiver Operating Characteristic (ROC) analysis (P<0.01). 5. Multifactor regression analysis confirmed the independence of PLR in assessing disease severity (P<0.01).
Conclusion: 1. QAlb, QIgG, QIgA, QIgM, and PLR have demonstrated efficacy as biomarkers for assessing the severity of NMOSD; 2.PLR has shown promise as a standalone indicator for evaluating disease severity in patients with NMOSD.
Maternal adverse childhood experiences on preschoolers' executive function: the chain mediating effect of parenting stress and child maltreatment
Authors: Zha Jinhong , Li Ruoyu , He Haiyan , Fang Peifei , Huang Rongling , Wan Yuhui 
Published: May 2024

Abstract

Background: Previous researches found that maternal ACEs not only affect the psychological behavior of preschool children, but also have direct or indirect negative effects on the executive functions (EFs) and cognition of offspring. And, the possible social psychological mechanism between maternal ACEs and preschool children's EFs is still not clear.
Objectives：This study mainly tries to understand the association between parenting stress and child maltreatment in maternal ACEs and children's EFs through longitudinal cohorts.
Participants and Setting: Participants were 2160 preschool children and their mothers who finally completed baseline and 3 waves of follow-up.
Methods: Using a cohort study, a baseline survey of junior kindergartens was carried out in June 2021 and followed up every six months, with a total of 3 follow-ups.
Results: We found that EFs in preschoolers were significantly positively correlated with maternal ACEs, parenting stress, physical assault, psychological aggression, neglect and nonviolent discipline (r = 0.180, 0.386, 0.274, 0.302, 0.189, 0.148, respectively, P<0.01). Further, parenting stress and child maltreatment showed a chain mediating effect between maternal ACEs and EFs in preschoolers, and the total indirect effects accounted for 70.56%, 78.69%, 65.38%, and 68.07% of the total effect, respectively.
Conclusions: This study found that maternal ACEs have a significant impact on the EFs of preschool children, and parenting stress and child maltreatment are the mediating factors of their association, revealing the potential mechanism between the two associations from the perspective of social psychology.
Relationships between Polymorphisms in HLA-G 3’UTR Region and COVID- 19 Disease Severity
Authors: Alyami Ahmad , Barnawi Fawziya , Christmas Steve , Alyafe Yusra , Awadalla Maaweya , Al-bayati Zaid , Mansour Lamjed 
Published: May 2024

Abstract

This study aims to discover how HLA-G gene variations and sHLA-G, as well as other host genetic factors, can affect SARS-CoV-2 infection. In this case-control study, 67 Patients with COVID-19 were and 65 healthy controls were genotyped for their main functional polymorphisms in the exon 8 of the 3' untranslated regions (3' UTRs) using sanger sequencing. Associations were assessed for five inheritance models (co-dominant, dominant, recessive, over-dominant and log-additive). Moreover, the levels of plasma soluble HLA-G (sHLA-G) were explored using ELISA method. Our results revealed all-main polymorphism in the 3’UTR region previously described for the HLA-G 3’UTR, namely, the 14-bp Ins/Del (rs371194629), +3003C/T (rs1707), + 3010C/G (rs1710), + 3027A/C (rs17179101), + 3035C/T (rs17179108), + 3142C/G (rs1063320), + 3187A/G (rs9380142) and + 3196C/G (rs1610696). The 14-bp INS/DEL polymorphism was strongly associated with COVID-19 symptoms development for almost all tested inheritance models (P < 0.001). Inversely, the (+3196C/G) polymorphism exhibited a protective effect against COVID-19. Three haplotypes; UTR-1, UTR-3, and UTR-5 were found associated with COVID-19 symptoms (P < 0.05), The level of HLA-G in the serum was significantly higher in COVID-19 individuals than in healthy individuals (P <0.001).These findings suggest that HLA-G gene polymorphisms in the regulatory 3’UTR region of the HLA-G gene may influence the host immune response to SARS-CoV-2 infection. A deeper comprehension of host genetics could be useful in identifying high-risk individuals and in the development of better treatments or vaccinations.
Proposal of Simultaneous Localization and Mapping for Mobile Robots Indoor Environments Using Petri Nets and Computer Vision
Authors: Mota Francisco Alan , Batista Josias Guimaraes , Alexandria Auzuir Ripardo 
Published: May 2024

Abstract

Studies in the area of mobile robotics have advanced in recent years, mainly due to the evolution of technology and the growing need for automated and dynamic solutions in sectors such as industry, transport and agriculture. These devices are complex and the ideal method for localizing, mapping and navigating autonomous mobile robots changes depending on the application. Thus, the general objective of this work is to propose a simultaneous localization and mapping method for autonomous mobile robots in indoor environments, using Computer Vision (CV) and Petri Net (PN). A landmark was placed next to each door in the analyzed region and images were acquired as the rooms in the environment were explored. The algorithm processes the images to count and identify the doors. A transition is created in the PN for each door found and the rooms connected by these doors are represented by the places in the PN. Then, one of the doors is crossed, new images are obtained and the process is repeated until all rooms are explored. The algorithm generates an PN, which can be represented by an image file (.png) and a file with the extension .pnml. The results compare the layout of four environments with the respective generated PNs. Furthermore, six evaluation criteria are proposed for validating Petri nets as a topological map of environments. It is concluded that using PN for this purpose presents originality and potential innovation, being a SLAM technique for indoor environments, which demands low computational cost.