bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Seabed Trenches Based on Floater Hydrodynamic Calculation
Authors: Rui S. , Zhou Z. , Jostad H. , Guo Z. , Wang L. , Xu H. 
Published: April 2024

AbstractInspections in the Gulf of Guinea indicated that a large number of seabed trenches appeared in front of suction anchors. The trenches had an adverse impact on the anchor capacity, which attracted wide attention from industry and academia. Currently, reliable methods need to be developed for accurately predicting the trench formation and development, for the benefit of both marine oil & gas resources and offshore wind. This paper proposes a procedure to evaluate trenches. The motion of semi-submersible floating structures is acquired under extreme environmental conditions to obtain the trajectory of platform fairlead. Then, three-dimensional (3-D) profile is evaluated according to the fairlead motion. Finally, some measures to reduce the trench dimensions are proposed by changing the mooring systems. The results indicate that the seabed trenches are easier to form in the soft clay due to its lower shear strength. The mooring line is hard to cut into sand, thus trench is unlikely to appear in sand according to the proposed method. Besides, trench formation is also related to mooring line tension and configuration. Increasing the mooring line length can reduce the disturbing soil regions, thus inhibiting the trench formation. Other methods, e.g., changing the mooring line components, can also change the disturbed soil region. This paper presents a design procedure from the hydrodynamic calculation of floater to the trench evaluation in sand and clay, which provides some useful guidance to taut and semi-taut mooring system design for marine resource exploitations.
Evaluate the Production Availability of an Offshore Wind Farm with a MBSA Model
Authors: Bougoüin B. , Estécahandy M. , Clément G. , Clavé N. 
Published: April 2024

TotalEnergies is a major player in the energy transition. All collaborators are mindful of the issues related to a just transition raised by our activities and our own transformation to achieve net-zero emissions by 2050, together with society, and they are providing concrete answers.
To achieve this, the company has itself the following objectives: Reduce greenhouse gas emissions as much as possible, in the operations for which it is directly responsible;Offset all remaining emissions, for example through CO2 capture projects;At the same time, propose an energy mix that is less and less carbon intensive with the development of renewable energies (solar, hydrogen, wind, etc.).
To enhance energy mix, from 2022 onwards, new offshore wind farm projects will emerge close to consumption grids and raise new questions which the Offshore Wind industry is preparing to tackle. To this end, Reliability Availability Maintainability (RAM) studies can help to define the best Operation and Maintenance (O&M) strategy to apply i.e., the one allowing to reach the optimum between OPerating EXpenditure (OPEX) and production availability [1] for a given farm's design.
How Production Chemicals Injection Can Reduce CO2 Emission?
Authors: Brunet-Coy F. , Gouayat E. , Lesage N. 
Published: April 2024

Abstract
Production chemicals are used to improve fluids production in gas and oil fields. These chemicals can contribute to less than 1% (0,1 kg/boe) of the global CO2 emission of a production site (scope 3). On the other hand, production chemicals can support the reduction of the global CO2 emission (Replacement of High CO2 emission chemicals by lower CO2 emission chemicals; Use more efficient chemicals to reduce chemicals consumption to reduce associated CO2 emission; Use production chemicals to improve energy efficiency or limit greenhouse gas emission…).
A methodology, based on Life Cycle Assessment (LCA), was developed with SIMAPRO®. This methodology is considering the global usage of the chemicals and its impact on the process (production increase, GHG reduction….).
Results point out that injection of a more efficient chemical can reduce the global carbon footprint. 2 chemistries were compared to scavenge H2S. The replacement of triazine based scavenger by a MBO base scavenger is leading to a decrease of the scavenger injection rate. Even if the costs ($/L) and the CO2 footprint (kgCO2/L) of MBO are higher, global impacts are positive (45% CO2 emission reduction).
Injection of a H2S scavenger to valorize the associated gas produced by an oil field (stop of flaring) shows that it is possible to reduce by more than 99% the global CO2 emissions.
Flowing improvement in an oil field pipeline with DRA injection can lead to the reduction of the carbon footprint intensity (reduction of CO2 emission per barrel of oil).
Other cases studies confirm that production chemicals (DRA, demulsifier…) management allow improving the global CO2 footprint.
Resource Modeling Assessment and Environmental Biological Analysis in Turnagain Arm, Cook Inlet, AK
Authors: Lee C. , Yang Z. , Copping A. 
Published: April 2024

Abstract
The deployment and operation of a floating and/or submerged tidal technology in the United States coastal water require characterizing tidal stream resource potential and assessing environmental conditions and satisfying all environmental permitting requirements. The waters of Cook Inlet, Alaska have some of the strongest and most consistent tidal currents in the U.S. This project seeks to examine the potential for tidal energy development in Turnagain Arm, an inlet between Anchorage and the Kenai Peninsula (Figure (a)), in the upper Cook Inlet. The Turnagain Arm Tidal Electricity Generation (TATEG) site covers 137 square miles of Turnagain Arm where the tidal range at the site reaches 10m, and has been awarded a FERC preliminary permit P#15109 (Figure (b)). While there is some preliminary data available, this site’s water speeds, environmental and biological concerns have not previously been characterized. Tidal Energy Corporation has requested technical assistance from Pacific Northwest National Laboratory for their expertise in assessing these characteristics.
The technical assistance provided under this award is intended to examine the tidal currents and assess those that are most suitable for tidal energy development through validated numerical models, and to assess the optimal tidal turbine deployment areas within Turnagain Arm from an environmental, logistic, and regulatory perspective. Areas that are best suited for bottom based, mid column and floating tidal technologies will be considered.
Tidal Energy Corp is proposing to develop TATEG into the United States’ first grid scale tidal stream development. TEC is also proposing that a portion of the TATEG site is dedicated to the formation of a permanent tidal energy prototype test site. This request for technical assistance with environmental assessment, likely permitting and regulatory pathways, and numerical modeling for overall site characterization is foundational to any and all development of the site.
Emergence and Distribution of Diverse Serovars of Non-Typhoidal Salmonellae in Mangalore, Coastal Karnataka: A 12-year Experience
Authors: Antony Beena , Shetty Anup Kumar , Kuruvilla Thomas S. 
Published: April 2024

Background and Aim:
Non-Typhoidal
Salmonellae (NTS) is emerging as a major health problem globally. They cause foodborne infections, especially gastroenteritis as well as extraintestinal manifestations. As this is a zoonotic disease, certain animal sources such as poultry, egg, meat and dairy products are implicated. Fruits and vegetables too contaminated by manure of infected animal excreta are possible vehicles of transmission of this disease. The present report analyzes the spectrum of NTS with seroprofiling, isolated in our institute for the last 12 years.

Materials and Methods:
Fresh fecal samples from patients with acute gastroenteritis and blood samples from cases of bacteremia were processed according to the standard protocol. Nonlactose fermenting colonies resembling Salmonella were subjected to biochemical characterization and antimicrobial susceptibility testing followed by serotyping.

Results:
One hundred fifty-two NTS strains were isolated from feces and 13 from blood. Serotyping of these strains revealed that the most common NTS species was Salmonella Typhimurium (44.8%), followed by Salmonella Oslo (15.2%) and Salmonella Weltevreden (11.5%). Many rare strains were also encountered in our study.

Conclusion:
As many of the NTS species are biochemically similar, serotyping of NTS should be made mandatory to know the burden of the disease and to detect the emergence of new serovars. Emergence of multidrug resistance in NTS strains is a major concern nowadays. It is very essential to adopt strict quality measures in poultry, fish, dairy, and meat processing units as they are widely distributed in animals. In addition, strategies should be formulated by health education and public awareness programs to sensitize the population regarding this menace.
An Observational Study of Glomerular Functions in Beta-thalassemia Major Children by Schwartz Formula and Technetium 99m Diethylenetriaminepentaacetic Acid Renogram
Authors: Mandal Sukanta , Bose Tathagata , Gulati Rachna , Ahuja Manish Singh 
Published: April 2024

Background and Aim:
Kidney dysfunction is reported in significant number of beta thalassemia major children. The aim of this study was to determine the prevalence of glomerular dysfunction in beta-thalassemia major children on regular blood transfusion (BT) and chelation therapy, and to find the correlation between glomerular filtration rate (GFR) estimated by Schwartz formula and Technetium 99m diethylenetriaminepentaacetic acid (99mTc-DTPA) renogram with ferritin level and cumulative transfusion load.

Materials and Methods:
An observational cross-sectional study conducted was done on 110 children diagnosed with beta-thalassemia major receiving regular BT and chelation therapy. Clinical examination, biochemical investigations (serum creatinine, ferritin) and DTPA renal scan were done. Estimated GFR calculation was done by Schwartz method and 99mTc-DTPA scan. The normal values of GFR were taken from the standard value as per KDIGO guidelines. P < 0.05 was considered statistically significant.

Results:
The prevalence of glomerular dysfunction by Schwartz formula and DTPA renogram was 44% and 24%, respectively. The GFR calculation (Schwartz formula and DTPA renogram) were weakly positively correlated (r = 0.126, P = 0.547). There was significant association between GFR Schwartz and duration of iron chelation, as children with abnormal GFR had significantly more duration of iron chelation >5 years (28% vs. 4%, P = 0.003). GFR (Schwartz formula and DTPA renogram) showed no association with cumulative transfusion load and disease duration (P > 0.05). GFR Schwartz formula and GFR–DTPA showed no correlation with serum ferritin with r = 0.179, (P = 0.392) and r = 0.278 (P = 0.178).

Conclusion:
There is a significant derangement in the renal function of children of beta-thalassemia major on chronic BT and iron chelation therapy. GFR holds a direct correlation with the increasing duration of iron chelation.
Association between Regular Exercise and Urinary Uric Acid Excretion in Chinese Adults: A Cross-sectional Study
Authors: Wang Wenjuan , Zhou Xiaoying , Liu Yu , Sang Miaomiao , Sun Zilin , Qiu Shanhu 
Published: April 2024

Abstract
Regular exercise decreases the risk of hyperuricemia, which is related to reduced urinary uric acid excretion (UUA/UAE). However, few studies have assessed the association between regular exercise and UAE. We conducted this study to investigate their associations in the general population. This was a cross-sectional study that involved a total of 5513 Chinese community-dwellers, who reported data on physical exercise. Fasting morning spot urine was used to measure UUA and creatinine. UAE was primarily assessed by UUA to creatinine ratio (UCr) and secondly by excretion of uric acid per volume of glomerular filtration (EurGF) and fractional excretion of uric acid (FEua). Linear regression analysis was used to assess their associations. Of the included participants, their mean age was 55.1 ± 13.0 years, and 1984 (36.0%) undertook regular exercise. Compared with participants with regular exercise, those with irregular exercise or no exercise had higher UUA/UCr (0.36 ± 0.15 vs. 0.39 ± 0.15, P < 0.001), EurGF (0.23 ± 0.10 vs. 0.24 ± 0.11 mg/dL, P < 0.001), and FEua (0.07 ± 0.04 vs. 0.08 ± 0.04, P = 0.006). These associations remained significant after controlling for multivariable including serum uric acid (SUA) or upon the exclusion of participants with renal dysfunction or urinary tract infection. In conclusion, regular exercise might be associated with decreased UAE, independent of SUA, in Chinese community-dwellers.
Overexpression of miR-204-5p Alleviates Osteogenic Differentiation and Calcification of Human Aortic Vascular Smooth Muscle Cells by Targeting Calcium/Calmodulin-dependent Protein Kinase 1
Authors: Wang Chunli , Xu Mingzhi , Bai Yafei , Pan Mingjiao , Qi Yonghui , Chen Ruman 
Published: April 2024

Abstract
Vascular calcification (VC), a major complication in chronic kidney disease (CKD), is predominantly driven by osteoblastic differentiation. Recent studies have highlighted the crucial role of microRNAs in CKD’s pathogenesis. Here, our research focused on the effects of miR-204-5p and its molecular mechanisms within VC. We initially found a notable decrease in miR-204-5p levels in human aortic vascular smooth muscle cells stimulated with inorganic phosphate, using this as a VC model in vitro. Following the overexpression of miR-204-5p, a decrease in VC was observed, as indicated by alizarin red S staining and measurements of calcium content. This decrease was accompanied by lower levels of the osteogenic marker, runt-related transcription factor 2, and higher levels of α-smooth muscle actin, a marker of contractility. Further investigation showed that calcium/calmodulin-dependent protein kinase 1 (CAMK1), which is a predicted target of miR-204-5p, promotes VC. Conversely, overexpressing miR-204-5p reduced VC by suppressing CAMK1 activity. Overexpressing miR-204-5p also effectively mitigated aortic calcification in an in vivo rat model. In summary, our research indicated that targeting the miR-204-5p/CAMK1 pathway could be a viable strategy for mitigating VC in CKD patients.
Dynamic Muscle Function Parameters in Indian Children and Adolescents with Type 1 Diabetes Mellitus: A Case-Control Study
Authors: Kasture Sonal V. , Mondkar Shruti A. , Khadilkar Anuradha V. , Gondhalekar Ketan , Sethi Anshu , Khadilkar Vaman V. 
Published: April 2024

Abstract

Introduction:
Recent evidence reveals that type 1 diabetes mellitus (T1DM) impairs muscle function (MF) in adolescents. However, despite its importance in physical well-being, data on dynamic MF in Indian children and adolescents (C and Y) with T1DM are scarce. We assessed MF using Jumping Mechanography (JM, a measurement method for motion analysis and assessment of muscle power and force). (1) To assess dynamic MF by JM in C and Y with T1DM as compared to healthy controls (2) To determine predictors of MF in children with T1DM.

Methods:
A cross-sectional observational study on 266 children (133 – T1DM duration >1 year with no known comorbidities + 133 age and gender-matched healthy controls) aged 6–19 years. Anthropometry, body composition, and MF (maximum relative power Pmax/mass, maximum relative force Fmax/BW by JM) were recorded. The lean mass index (LMI) was calculated as lean mass (kg)/height (m2). HbA1c was assessed in T1DM. Independent sample t-test and linear regression were performed.

Results:
MF parameters (Pmax/mass 33.5 ± 7.2 vs 38.0 ± 8.6 W/kg and Fmax/BW 10.5 ± 2.9 vs 11.4 ± 4.1 N/kg, P < 0.05) were significantly lower in T1DM group vs controls. Positive association of body mass index and LMI with both MF parameters and negative association of insulin requirement and HbA1c with Fmax was observed in T1DM. Predictors of MF identified were MMI (Pmax/mass:b = 1.6,95%CI = 0.6–2.6; Fmax/BW:b =2.0,95%CI = 1.6–2.4) and HbA1c (Pmax/mass:b = −2.1,95%CI = −4.5–−0.5; Fmax/BW:b = −1.1,95%CI = −2.0–−0.2) (P < 0.05).

Conclusion:
C and Y with T1DM exhibits compromised muscle function. Poor glycaemic control increases the risk of having decreased MF, irrespective of diabetes duration and may contribute to sarcopenia in adulthood.
Role of Dietary Macronutrient Composition and Fibre Intake in Development of Double Diabetes in Indian Youth
Authors: Oza Chirantap , Mandlik Rubina , Khadilkar Anuradha V. , Gondhalekar Ketan M. , Khadilkar Vaman V. 
Published: April 2024

Abstract

Introduction:
Insulin resistance (IR) and obesity are common presentations of double diabetes (DD) in subjects with type-1 diabetes (T1D). There is evidence that dietary composition has an impact on developing IR. Objectives were to assess the impact of macronutrient and fibre intake on glycaemic control and the role of macronutrient composition of diet in the development of DD in subjects with T1D.

Methods:
This cross-sectional study included 77 young adults (10–25 years) with T1D. Data related to demography, anthropometry, biochemistry and body composition were collected. Dietary data was collected by fourteen-day food diary. IR was calculated using eGDR, SEARCH and CACTI equations, and metabolic syndrome (MS) was diagnosed using the International Diabetes Federation Consensus Definition.

Results:
Subjects at risk of DD had higher age, leptin levels, percentage carbohydrate consumption in diet and IR. A positive association of insulin sensitivity with fibre intake and %protein intake was noted. Poor glycaemic control, adiponectin/leptin ratio, fibre intake and insulin/carbohydrate ratio were significant negative predictors of IR. Addition of dietary factors to the regression model improved the R square and percentage of subjects identified correctly. Inclusion of dietary parameters significantly improves the prediction of the risk of development of DD in subjects with T1D.

Conclusion:
Good glycaemic control and increased intake of dietary fibre may prevent the development of IR in subjects with T1D and reduce the burden of DD.
Antiarthritic potential of ethanolic extract of Ixora coccinea leaves on complete Freund’s adjuvant-induced arthritis in animal model
Authors: Panda Adyasha Anindita , Behera Jayanti Prava , Ramani Y. Roja , Panda Abinash , Kar Padmaja Priyadarshini , Panigrahy Snigdha Rani 
Published: April 2024

Abstract

CONTEXT:

Ixora coccinea leaves possess antioxidant, anti-inflammatory, antinociceptive, antimutagenic, and gastroprotective properties. On this background, its antiarthritic potential was evaluated.

AIMS:
The objective is to evaluate the effect of Ethanolic extract of Ixora coccinea leaves (EEICL) on complete Freund’s adjuvant-induced arthritis in rats.

SETTINGS AND STUDY DESIGN:
PG research laboratory, Pharmacology Department, MKCG Medical College, Berhampur, Odisha.

SUBJECTS AND METHODS:
Thirty-six Wistar albino rats were randomly distributed into sixgroups (n = 6) as follows: Gr 1 (normal control)-DW p.o, Gr-2 (disease control [DC] - Tween 80 p.o), Gr-3 (piroxicam 0.9 mg/kg p.o), Gr-4 (EEICL-1 g/kg, p.o, Gr 4-EEICL-1.5 g/kg p.o, Gr 5-ED50 (0.82 g/kg) + piroxicam (0.45 mg/kg) p.o. After induction of arthritis, drugs, and vehicles were administered daily from 5th to 25th day. On 0, 5th, 10th, 15th, and 25th day, parameters like body weight, rotarod fall time, paw volume displacement, and arthritis index were measured. On the last day, Erythrocyte sedimentation rate (ESR), tissue malondialdehyde (MDA), and histopathological analysis were done.

STATISTICAL ANALYSIS USED:
Analysis of parametric data was done by one-way ANOVA and nonparametric data by Kruskal–Wallis test using graph pad prism 7.0. P < 0.05 was considered statistically significant.

RESULTS:
EEICL (1.5 mg/kg) showed anti-arthritic effect compared with DC. Rotarod fall-off time 137.5 ± 2.5 sec and body weight (139 ± 12.74 g) were increased significantly. The percentage inhibition of paw volume was increased(52%) whereas arthritic score(0.33), ESR(3.51mm/hr), synovial tissue MDA level (0.62±0.13µmol/gm) and Mankin score(2) were reduced significantly as compared to disease control.

CONCLUSIONS:
EEICL has anti-arthritic potential in rat model.
Wound-healing effect of topical nanoemulsion-loaded cream and gel formulations of Hippophae rhamnoides L. (sea buckthorn) fruit oil and their acute dermal toxicity study on female SD rats
Authors: Gore Dattatraya Dinkar , Sharma Nisha , Mishra Nidhi , Parmar Prashantkumar K. , Ranjana Soni , Kumar Dinesh , Jachak Sanjay M. , Jena Gopabandhu , Tikoo Kulbhushan , Bansal Arvind K. , Singh Inder Pal 
Published: April 2024

Abstract

OBJECTIVE:
The objective of this study was to evaluate the efficacy and safety of topical nanoemulsion (NE)-loaded cream and gel formulations of Hippophae rhamnoides L. (sea buckthorn [SBT]) fruit oil for wound healing.

MATERIALS AND METHODS:
The NE-loaded cream and gel formulations of H. rhamnoides L. (SBT) fruit oil (IPHRFH) were prepared and evaluated for their wound-healing activity on female Sprague–Dawley (SD) rats. They were further divided into groups (seven) and the wound-healing activity was determined by measuring the area of the wound on the wounding day and on the 0th, 4th, 8th, and 10th days. The acute dermal toxicity of the formulations was assessed by observing the erythema, edema, and body weight (BW) of the rats.

RESULTS:
The topical NE cream and gel formulations of H. rhamnoides L. (SBT) fruit oil showed significant wound-healing activity in female SD rats. The cream formulation of IPHRFH showed 78.96%, the gel showed 72.59% wound contraction on the 8th day, whereas the positive control soframycin (1% w/w framycetin) had 62.29% wound contraction on the 8th day. The formulations also showed a good acute dermal toxicity profile with no changes significantly affecting BW and dermal alterations.

CONCLUSIONS:
The results of this study indicate that topical NE-loaded cream and gel formulation of H. rhamnoides L. (SBT) fruit oil are safe and effective for wound healing. The formulations showed no signs of acute dermal toxicity in female SD rats.
Antitumor activity of extracellular signal-regulated kinases 1/2 inhibitor BVD-523 (ulixertinib) on thyroid cancer cells
Authors: Chen Yulu , Xiao Xi , Hu Guanghui , Liu Rengyun , Xue Junyu 
Published: April 2024

ABSTRACT

Objective:
This study aimed to investigate BVD-523 (ulixertinib), an adenosine triphosphate (ATP)-dependent extracellular signal-regulated kinases 1/2 inhibitor, for its antitumor potential in thyroid cancer.

Materials and Methods:
Ten thyroid cancer cell lines known to carry mitogen-activated protein kinase (MAPK)-activated mutations, including v-Raf murine sarcoma viral oncogene homolog B (BRAF) and rat sarcoma virus (RAS) mutations, were examined. Cells were exposed to a 10-fold concentration gradient ranging from 0 to 3000 nM for 5 days. The half-inhibitory concentration was determined using the Cell Counting Kit-8 assay. Following BVD-523 treatment, cell cycle analysis was conducted using flow cytometry. In addition, the impact of BVD-523 on extracellular signal-regulated kinase (ERK)- dependent ribosomal S6 kinase (RSK) activation and the expression of cell cycle markers were assessed through western blot analysis.

Results:
BVD-523 significantly inhibited thyroid cancer cell proliferation and induced G1/S cell cycle arrest dose-dependently. Notably, cell lines carrying MAPK mutations, especially those with the BRAF V600E mutation, exhibited heightened sensitivity to BVD-523’s antitumor effects. Furthermore, BVD-523 suppressed cyclin D1 and phosphorylated retinoblastoma protein expression, and it robustly increased p27 levels in an RSK-independent manner.

Conclusion:
This study reveals the potent antitumor activity of BVD-523 against thyroid cancer cells bearing MAPK-activating mutations, offering promise for treating aggressive forms of thyroid cancer.