bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term clinical outcome of rotational atherectomy followed by drug‐eluting stent implantation in complex calcified coronary lesions
Authors: Abdel‐Wahab Mohamed , Baev Radoy , Dieker Patrick , Kassner Guido , Khattab Ahmed A. , Toelg Ralph , Sulimov Dmitriy , Geist Volker , Richardt Gert 
Published: March 2012

ObjectivesTo assess long‐term outcome after rotational atherectomy (RA) is followed by drug‐eluting stent (DES) implantation in complex calcified coronary lesions.BackgroundRA can favorably modify heavily calcified coronary lesions, but long‐term outcome is poor when it is used as a stand‐alone therapy or combined with bare‐metal stents. DES have reduced rates of restenosis in a wide range of patient and lesion subsets, but little information is available on long‐term clinical outcome when RA is followed by DES implantation (Rota‐DES) in complex calcified lesions.Methods and ResultsTwo hundred and five patients with de novo complex calcified coronary lesions treated with Rota‐DES were analyzed. Mean age was 69.7 ± 9.3 years, 63 patients (31%) had diabetes mellitus and 21 patients (10%) had chronic renal failure. Total stent length/patient was 32 mm. The majority of patients were treated with paclitaxel‐eluting stents (64%) or sirolimus‐eluting stents (30%). Angiographic success rate was 98%. The incidence of in‐hospital major adverse cardiac events (MACE), defined as death, myocardial infarction (MI), and target vessel revascularization (TVR), was 4.4%. Long‐term follow‐up was available for 188 patients (92%). At a median follow‐up period of 15 months (range, 1–84), the cumulative incidence of MACE (Kaplan–Meier estimate) was 17.7%. Death occurred in 4.4%, MI in 3.4%, TVR in 9.9%, and target lesion revascularization (TLR) in 6.8%. One definite (0.5%) and one probable (0.5%) stent thrombosis were observed. In a multivariate analysis, low ejection fraction (<40%) was the only independent predictor of MACE, and both age and diabetes were independent predictors of TLR.ConclusionThis study represents the largest European data set of patients treated with RA in the DES era. RA followed by DES implantation in calcified coronary lesions appears to be feasible and effective, with a high rate of procedural success and low incidence of TLR and MACE at long term considering this complex patient and lesion subset. © 2012 Wiley Periodicals, Inc.
Impact of different stent alloys on human vascular response to everolimus‐eluting stent: An optical coherence tomography study: The OCTEVEREST
Authors: Guagliumi Giulio , Capodanno Davide , Ikejima Hideyuki , Bezerra Hiram G. , Sirbu Vasile , Musumeci Giuseppe , Fiocca Luigi , Lortkipanidze Nikoloz , Vassileva Angelina , Tahara Satoko , Valsecchi Orazio , Costa Marco A. 
Published: March 2012

BackgroundNew generation drug‐eluting stents (DES) incorporate thinner struts and novel alloys to improve clinical performance. Nevertheless, the impact of novel stent materials and designs on human vascular response to DES remains elusive. We sought to evaluate the in‐vivo coronary artery response to platinum‐chromium (PtCr) versus cobalt‐chromium (CoCr) stents featuring the same durable polymer and antiproliferative drug by optical coherence tomography (OCT).Methods and ResultsA total of 42 patients with de novo lesions in native coronary vessels was treated with PtCr‐everolimus eluting stent (EES; n = 21) or CoCr‐EES (n = 21). Angiography, intravascular ultrasound, and OCT were performed at the index procedure and 6‐month follow‐up. PtCr‐EES and CoCr‐EES had similar concentric expansion (stent eccentricity index; median 0.91 vs. 0.90, respectively, P = 0.47) and very low rate of strut malapposition (median 1.15 vs. 1.80%, P = 0.92) at post implantation. Proportion of struts embedded in tissue was lower in PtCr‐EES compared to CoCr‐EES (median 2.67 vs. 15.23%, P < 0.001). The primary prespecified end point, the percentage of uncovered struts per patient at 6 months follow‐up, was 8.46% [interquartile range (IQR) = 3.05–17.26] in PtCr‐EES and 5.88% (IQR = 1.35–13.27) in CoCr‐EES (P = 0.36), whereas malapposed struts were observed in 0.00% (IQR = 0.00–0.25) versus 0.48% (IQR = 0.00–1.44), respectively, (P = 0.10). Strut‐level neointimal thickness did not differ between the two platforms (median 0.09 vs. 0.08 mm, P = 0.49).ConclusionsAcute and mid‐term responses to EES using PtCr or CoCr platforms were similar, with concentric stent expansion, low malapposition, similar strut coverage and limited amount of neointima. Conversely, at postprocedure, PtCr‐EES had fewer embedded struts compared with CoCr‐EES. © 2012 Wiley Periodicals, Inc.
Five‐year clinical outcomes of a polymer‐free sirolimus‐eluting stent versus a permanent polymer paclitaxel‐eluting stent: Final results of the intracoronary stenting and angiographic restenosis – test equivalence between two drug‐eluting stents (ISAR‐TEST) trial
Authors: King Lamin , Byrne Robert A. , Mehilli Julinda , Schömig Albert , Kastrati Adnan , Pache Jurgen 
Published: March 2012

AbstractBackgroundLimited evidence exists regarding the long‐term performance of polymer‐free (PF) drug‐eluting stents (DES) in comparison to permanent polymer DES. This study investigated the 5‐year efficacy and safety of a PF sirolimus‐eluting stent (PF‐SES) versus a permanent polymer paclitaxel‐eluting stent (PES) in the setting of the Intracoronary Stenting and Angiographic Restenosis‐Test Equivalence Between Two Drug‐Eluting Stents (ISAR‐TEST) randomized trial.Methods and ResultsA total of 450 patients undergoing percutaneous coronary intervention were randomized to receive either PF‐SES (Yukon, Translumina; n = 225) or PES (Taxus, Boston Scientific; n = 225). Clinical follow‐up was performed to 5 years after enrollment. The endpoints were major adverse cardiac events (MACE), target lesion revascularization (TLR), the composite of death or any myocardial infarction (MI) and stent thrombosis (ST). The incidence of MACE at 5 years was 27.3% (57 patients) in the PF‐SES group and 31.7% (65 patients) in the PES group [hazard ratio (HR) = 0.87 [95% confidence interval (95% CI) = 0.61–1.24]; P = 0.40]. The combined incidence of death or MI was 16.6% (34 patients) in the PF‐SES group and 20.0% (39 patients) in the PES group (HR = 0.86 [95% CI = 0.54–1.36]; P = 0.52). The incidence of TLR was 16.5% (34 patients) in the PF‐SES group and 16.4% (33 patients) in the PES group (HR = 1.03 [95% CI = 0.64–1.66]; P = 0.89). ST occurred in 0.5% (one patient) in the PF‐SES group and 1.6% (three patients) in the PES group (HR = 0.33 [95% CI = 0.03–3.14]; P = 0.32).ConclusionOverall there was no significant difference in clinical outcomes between PF‐SES and PES to 5 years. Extended follow‐up supports the durability of efficacy and safety of PF‐SES. © 2012 Wiley Periodicals, Inc.
Long‐term luminal change after drug‐eluting stent implantation: Serial angiographic follow‐up study of the ZEST randomized trial
Authors: Park Gyung‐Min , Park Duk‐Woo , Kim Yong‐Giun , Cho Sung Won , Sun Byung‐Joo , Hwang Ki Won , Kim Yoo Ri , Ahn Jung‐Min , Song Hae‐Geun , Kim Won‐Jang , Lee Jong‐Young , Kang Soo‐Jin , Lee Seung‐Whan , Kim Young‐Hak , Lee Cheol Whan , Park Seong‐Wook , Park Seung‐Jung 
Published: March 2012

ObjectiveTo evaluate long‐term patterns of luminal changes after implantation of different types of drug‐eluting stents (DES), we analyzed the serial angiographic outcomes of patients implanted with zotarolimus‐eluting stents (ZES), sirolimus‐eluting stents (SES), or paclitaxel‐eluting stents (PES).BackgroundLittle is known regarding long‐term luminal changes after DES implantation.MethodsAs a subgroup analysis of the ZEST trial, we performed complete angiographic evaluation immediately after the procedure and at 9 months and 2 years in 111 patients with 165 lesions (36 patients with ZES, 40 with SES, and 35 with PES).ResultsBaseline clinical, angiographic, and procedural characteristics were similar among the three groups. Quantitative angiographic analysis revealed significant decreases in minimal luminal diameter 9 months after stent implantation in the ZES (from 2.71 ± 0.49 to 2.21 ± 0.42 mm, P < 0.001), SES (from 2.79 ± 0.49 to 2.58 ± 0.57 mm, P < 0.001), and PES (from 2.66 ± 0.45 to 2.19 ± 0.52 mm, P < 0.001) groups. However, significant late improvements with different degree in luminal diameter were observed between 9 months and 2 years in the ZES (from 2.21 ± 0.42 to 2.39 ± 0.58 mm, P = 0.001), SES (from 2.58 ± 0.57 to 2.66 ± 0.60 mm, P = 0.039), and PES (from 2.19 ± 0.52 to 2.43 ± 0.52 mm, P < 0.001) groups.ConclusionSerial angiographic follow‐up study revealed a biphasic luminal response after DES implantation, characterized by an early progression phase for the first 9 months and a late regression phase from 9 months to 2 years. © 2012 Wiley Periodicals, Inc.
Dehydroalkylation of Benzene with Ethane over Pt/H‐MFI in the Presence of Hydrogen Scavengers
Authors: Ordomskiy V. V. , Rodionova L. I. , Ivanova I. I. , Luck F. 
Published: March 2012

AbstractThe alkylation of benzene with ethane has been studied over the Pt/H‐MFI catalyst in the presence of intermetallic compounds and titanium as hydrogen acceptors. The addition of hydrogen scavengers shifts the thermodynamic equilibrium of the reaction and allows for an improvement in the catalytic activity. In the presence of Ti, Zr2Fe, and ZrV2, the initial conversion of ethane increases by 5–7 times with respect to the neat catalyst. However, the positive effect of hydrogen acceptors decreased with time on stream, owing to saturation of their capacity.
Fabrication of Rice‐Like Porous Anatase TiO2 with High Thermal Stability and Enhanced Photocatalytic Performance
Authors: Sun Fanfei , Zhou Wei , Tian Guohui , Pan Kai , Miao Xiaohuan , Li Ying , Zhang Guoliang , Li Ting , Fu Honggang 
Published: March 2012

AbstractRice‐like porous anatase TiO2 with high crystallinity has been successfully synthesized by means of a facile hydrothermal method with the inorganic precursor titanyl sulfate, followed by calcination at higher temperature. The structures of the prepared TiO2 nanocrystals are characterized in detail by using XRD, Raman spectra, N2 adsorption/desorption isotherms, X‐ray photoelectron spectroscopy, SEM, and TEM. Experimental results indicate that the anatase crystalline structure could be maintained up to 800 °C, which is attributed to the protection of S‐containing species that are produced in situ during the hydrolysis of titanyl sulfate. They hinder the undesirable grain growth and aggregation, inhibit the anatase–rutile phase transformation, and protect the porous structure from collapse during the calcination process. The rice‐like porous anatase TiO2, after calcination at 700 °C, exhibits better photocatalytic activity than Degussa P 25 TiO2 in the degradation of highly toxic 2,4‐dichlorophenol under UV light irradiation. This improvement was attributed to the porous structure, which offers more active sites and facilitates mass transport, and the high crystallinity that favors the separation of photogenerated electron–hole pairs, which is confirmed by analysis of surface photovoltage spectra.
The Nature of the [TTF].+⋅⋅⋅[TTF].+ Interactions in the [TTF]22+ Dimers Embedded in Charged [3]Catenanes: Room‐Temperature Multicenter Long Bonds
Authors: Capdevila‐Cortada Marçal , Novoa Juan J. 
Published: March 2012

AbstractThe properties of tetrathiafulvalene dimers ([TTF]22+) and the functionalized ring‐shaped bispropargyl (BPP)‐functionalized TTF dimers, [BPP–TTF]22+, found at room temperature in charged [3]catenanes, were evaluated by M06L calculations. The results showed that their isolated [TTF]22+ and [BPP–TTF]22+ dimers are energetically unstable towards dissociation. When enclosed in the 4+‐charged central cyclophane ring of charged [3]catenanes (CBPQT4+), [TTF]22+ and [BPP–TTF]22+ dimers are also energetically unstable with respect to leaving the CBPQT4+ ring; since the barrier for the exiting process is only about 3 kcal mol−1, that is, within the reach of thermal energies at room temperature (neutral [TTF]20 dimers are stable within the CBPQT4+ ring). However, the [BPP–TTF]22+ dimers in charged [3]catenanes cannot exit, because this would imply breaking the covalent bonds of the BPP–TTF+ macrocycle. Finally, it was shown that the [TTF]22+, [BPP–TTF]22+ dimers, and charged [3]catenanes are energetically stable in solution and in crystals of their salts, in the first case due to the interactions with the solvent, and in the second case mostly due to cation–anion interactions. In these environmental conditions at room temperature the TTF units of the [BPP–TTF]22+ dimers make short contacts, thus allowing their SOMO orbitals to overlap: a room‐temperature multicenter long bond is formed, similar to those previously found in other [TTF]22+ salts and their solutions.
Electron Attachment to Solvated dGpdG: Effects of Stacking on Base‐Centered and Phosphate‐Centered Valence‐Bound Radical Anions
Authors: Gu Jiande , Liang Guoming , Xie Yaoming , Schaefer Henry F. 
Published: March 2012

AbstractTo explore the nature of electron attachment to guanine‐centered DNA single strands in the presence of a polarizable medium, a theoretical investigation of the DNA oligomer dinucleoside phosphate deoxyguanylyl‐3′,5′‐deoxyguanosine (dGpdG) was performed by using density functional theory. Four different electron‐distribution patterns for the radical anions of dGpdG in aqueous solution have been located as local minima on the potential energy surface. The excess electron is found to reside on the proton of the phosphate group (dGpH−dG), or on the phosphate group (dGp.−dG), or on the nucleobase at the 5′ position (dG.−pdG), or on the nucleobase at the 3′ position (dGpdG.−), respectively. These four radical anions are all expected to be electronically viable species under the influence of the polarizable medium. The predicted energetics of the radical anions follows the order dGp.−dG>dG.−pdG>dGpdG.−>dGpH−dG. The base–base stacking pattern in DNA single strands seems unaffected by electron attachment. On the contrary, intrastrand H‐bonding is greatly influenced by electron attachment, especially in the formation of base‐centered radical anions. The intrastrand H‐bonding patterns revealed in this study also suggest that intrastrand proton transfer might be possible between successive guanines due to electron attachment to DNA single strands.
ChemInform Abstract: Activation of BaTaO2N Photocatalyst for Enhanced Non‐Sacrificial Hydrogen Evolution from Water under Visible Light by Forming a Solid Solution with BaZrO3.
Authors: Matoba Tamaki , Maeda Kazuhiko , Domen Kazunari 
Published: March 2012

AbstractThe activity of BaTaO2N for non‐sacrificial H2 evolution from water is improved by formation of a solid solution with BaZrO3 prepared by modifying Ba—Ta oxide particles with Ba—Zr oxide followed by nitridation at 1223 K for 20 h under flowing NH3.
ChemInform Abstract: A Zinc Phosphate Structure with Unusual Double‐Sheet Layers Templated by a Cobalt Hexaammine Complex.
Authors: Han Yide , Li Yi , Yu Jihong , Pan Qinhe , Xu Ruren 
Published: March 2012

AbstractLarge single crystals of the new compound [Co(NH3)6]3 [Zn8(HPO4)8(PO4)2] (PO4) are synthesized by hydrothermal reaction of Zn(OAc)2, Co(NH3)6Cl3, and H3PO4 (H2O, autoclave, 110 °C, 6 d).
ChemInform Abstract: New Five‐Coordinate Ru(II) Phosphoramidite Complexes and Their Catalytic Activity in Propargylic Amination Reactions.
Authors: Widaman Andria K. , Rath Nigam P. , Bauer Eike B. 
Published: March 2012

AbstractA new five‐coordinate square pyramidal Ru—phosphoramidite is prepared and successfully applied in the amination of propargylic acetates (I) with secondary amines.
ChemInform Abstract: Direct Synthesis of N‐Substituted Anilines from Nitroaromatics and Alcohols under H2 by Alumina‐Supported Silver Cluster Catalysts.
Authors: Shimizu Kenichi , Shimura Katsuya , Nishimura Masanari , Satsuma Atsushi 
Published: March 2012

AbstractThe direct synthesis of N‐benzyl‐substituted anilines is achieved for the first time by reaction of nitrobenzenes (I) with benzylic alcohols (II) in the presence of a heterogeneous Ag—Al2O3 catalyst.
ChemInform Abstract: Sulfamic Acid: An Efficient, Cost‐Effective and Green Catalyst for Crossed‐Aldol Condensation of Ketones with Aromatic Aldehydes under Solvent‐Free Conditions.
Authors: Rostami Amin , Ahmad‐Jangi Firoz 
Published: March 2012

AbstractThe procedure is generally efficient for the transformations, but requires different reaction temperature and time.
ChemInform Abstract: Titanium(IV) Chloride Mediated Intramolecular Ring Enlargement of Methylenecyclopropanes with Propargylic Esters: A Concise Synthesis of Bicyclo[4.2.0]oct‐5‐ene Derivatives.
Authors: Zhang Zhen , Shi Min 
Published: March 2012

AbstractCarbocyclization of enyne derivatives (I) and (IV) under mild conditions offers a novel synthetic route to bicyclic N‐heterocycles (II)/(III) as important scaffolds.
ChemInform Abstract: Synthesis and Preliminary Evaluation of Amiloride Analogues as Inhibitors of the Urokinase‐Type Plasminogen Activator (uPA).
Authors: Matthews Hayden , Ranson Marie , Tyndall Joel D. A. , Kelso Michael J. 
Published: March 2012

AbstractAmiloride analogues (VI) are the most potent compounds identified in the study with nearly 6‐fold increase in potency relative to amiloride.
ChemInform Abstract: Efficient Syntheses of 3‐Phosphorylquinolin‐4‐ones and 3‐Phosphoryl‐1,8‐naphthyridine‐4‐ones.
Authors: Kedzia Jacek , Modranka Jakub , Janecki Tomasz 
Published: March 2012

AbstractA new four step sequence from readily available substrates (I) faciliates the synthesis of the title compounds (VIII).
Shedding Light on Intermolecular Metal–Organic Ring Interactions by Theoretical Studies
Authors: Konidaris Konstantis F. , Tsipis Athanassios C. , Kostakis George E. 
Published: March 2012

AbstractMetal–organic ring interactions (MORi) represent a kind of supramolecular interaction with a stacking character, which is formed between five and/or six‐membered chelated rings; the latter occur when a pseudopeptidic‐type of ligand (malonamide‐N,N′‐dicarboxylic acid) chelates to CuII which favors a square‐planar geometry. So far, a series of CuM compounds (M=Ca, Ln) with diverse structural characteristics have been isolated, varying from discrete coordination clusters to multidimensional polymers; their common feature is the presence of five and six‐membered chelated rings stacked together. In this study, the nature of MORi was investigated at the DFT level (B3LYP‐D/TZ2P) by using an energy decomposition analysis (EDA) of the interaction energy between the two CuII complexes in the dimeric monomer unit chosen. The EDA calculations showed that the intermolecular interactions in three heterometallic CuM compounds (M=Li, Na, Ca) arise from dispersion forces, electrostatic interactions, and hydrogen bonds.
MRI Paramagnetic Probes for Cellular Labeling
Authors: Gianolio Eliana , Stefania Rachele , Di Gregorio Enza , Aime Silvio 
Published: March 2012

AbstractThis review discusses the main procedures that have been developed for pursuing the task of an efficient cellular labelling with paramagnetic metal complexes for MRI detection. Although most of the work deals with GdIII‐based relaxation enhancers it is shown that the emerging class of paraCEST agents can allow the visualization of more cell types in the same MR image. To improve the detection of labelled cells, it is often necessary to deal with the use of nano‐sized carriers able to deliver a large number of paramagnetic metal complexes. Finally, selected examples are reported to show how proper design of the paramagnetic complex can offer the way to acquire key information on underlying processes in the labelled cells.
Synthesis and Structural Characterization of Homochiral Homo‐Oligomers of cis‐γ‐Methoxy‐Substituted cis‐ and trans‐Furanoid‐β‐Amino Acids
Authors: Giri Awadut G. , Jogdand Ganesh F. , Rajamohanan Pattuparampil R. , Pandey Sunil K. , Ramana Chepuri V. 
Published: March 2012

AbstractHerein we describe the synthesis of cis‐/trans‐3‐aminotetrahydrofuran‐2‐carboxylic acids (cis‐/trans‐FAA) having a γ‐methoxy group cis to the amine. The homo‐oligomers of these two diastereomeric FAAs have been prepared. Preliminary investigation of their solution secondary structures revealed that they are the same as the homo‐oligomers of the parent cis‐/trans‐FAA with the methoxy group only being a spectator substituent.
Expeditious Racemic and Enantiodivergent Synthesis of 1‐Deoxymannojirimycin and 1,4‐Dideoxymannojirimycin
Authors: Scarpi Dina , Bartali Laura , Casini Andrea , Occhiato Ernesto G. 
Published: March 2012

AbstractThe racemic and enantiodivergent syntheses of 1‐deoxymannojirimycin (DMJ) and 1,4‐dideoxymannojirimycin have been realized through key enamide ester intermediates obtained by converting cis‐4,5‐dihydroxylated δ‐valerolactam derivatives into the corresponding enol phosphates and subjecting them to Pd‐catalyzed methoxycarbonylation. Further elaborations of these intermediates included stereocontrolled catalytic hydrogenation, for the synthesis of racemic 1,4‐dideoxymannojirimycin, and hydroboration/oxidation, for the synthesis of DMJ. Enantiodivergency was attained by optical resolution before exhaustive functional group deprotection, through the formation of diastereomeric camphanic esters. As the key racemic intermediate esters were easily prepared in a few steps on a large scale, and the final chromatographic separation of the camphanic esters was straightforward, this approach represents a convenient way to obtain both enantiomers of DMJ for medicinal chemistry studies.
[3+2] Cycloaddition of Dialkyl (E)‐Hex‐2‐en‐4‐ynedioates to [60]Fullerene by Phosphane‐Promoted Tandem α(δ′)‐Michael Additions
Authors: Chuang Shih‐Ching , Deng Jie‐Cheng , Chan Fu‐Wei , Chen Sheng‐Yuan , Huang Wei‐Je , Lai Li‐Hsiang , Rajeshkumar Venkatachalam 
Published: March 2012

AbstractOrganophosphanes promote the [3+2] cycloaddition reactions of dialkyl (E)‐hex‐2‐en‐4‐ynedioates and [60]fullerene, giving a series of cyclopenteno‐fullerenes 3a–k bearing phosphorus ylides. This cycloaddition reaction is initiated by the attack of nucleophilic phosphanes at the α(δ′)‐C atom of the dialkyl (E)‐hex‐2‐en‐4‐ynedioate, which generates a 1,3‐dipolar species. These 1,3‐dipoles then react with C60 followed by intramolecular cyclization to give cyclopenteno‐fullerenes in moderate‐to‐good yields. In a cyclic voltmmetry study, these novel fullerenes show a larger cathodic shift in their first reduction potential relative to [6,6]phenyl‐C61 methyl butyrate, which indicates that these new derivatives possess higher LUMO energy levels.
Single‐Step, Regioselective Synthesis of Diazadioxacalix[4]arenes and Diazadioxa[14]cyclophanes Bearing an Alternating N/O‐Bridge Pattern
Authors: Bizier Nicholas P. , Vernamonti Jack P. , Katz Jeffrey L. 
Published: March 2012

AbstractDescribed is a single‐step synthesis of diazadioxacalix[4]arenes and diazadioxa[14]cyclophanes bearing an alternating N/O‐bridge substitution pattern. The macrocycles are formed regioselectively by condensation of 3‐ or 4‐aminophenols with 1,5‐difluoro‐2,4‐dinitrobenzene. Conformational properties of the macrocyclic products are discussed, as well as mechanistic details of the synthesis leading to the observed bridge‐pattern selectivity.