bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of an Educational Program to Improve Communication with Patients About Early-Phase Trial Participation
Authors: Fallowfield Lesley J. , Solis-Trapala Ivonne , Jenkins Valerie A. 
Published: March 2012

Abstract

Background.
Discussing early-phase cancer trials is challenging; most offer little personal benefit to patients with life-limiting illnesses who frequently have a poor understanding of and misconceptions about the therapeutic aims. We evaluated an evidence-based training program aimed at enhancing communication.

Methods.
Prior to and after the intervention, 47 health care professionals (HCPs) experienced in early-phase trial recruitment were audio taped discussing trials with patient simulators who completed postinterview evaluations. Coders rated the interviews for the presence of information areas required to elicit ethical consent. HCPs reported their self-confidence on 15 different aspects of trial discussion.

Results.
Significant objective and subjective improvements in communication were found after the workshop. Analyses of audio tapes showed positive shifts in: establishing the patient's knowledge of their prognosis (odds ratio [OR], 2.7; p = .002), discussing symptomatic care (OR, 3.8; p &lt; .001), the aims of the trial (OR, 2.6; p =.002), and the unlikelihood of medical benefit (OR, 3.0; p = .021). Patient simulator ratings showed improvements in: the awareness of palliative care and symptom control (OR, 2.1; p = .004), the voluntariness of participation (OR, 3.7; p = .015), the opportunity to ask questions (OR, 2.9; p = .044), and the time to consider participation (OR, 6.1; p = .009). HCPs' self-confidence increased significantly for all 15 items (OR range, 1.5–2.9; p ≤ .001).

Conclusion.
This short, intensive workshop changed communication skills competency and self-efficacy in ways likely to promote valid, ethically informed consent from patients contemplating trial entry.
Adult Brainstem Gliomas
Authors: Reyes-Botero German , Mokhtari Karima , Martin-Duverneuil Nadine , Delattre Jean-Yves , Laigle-Donadey Florence 
Published: March 2012

Abstract

Learning Objectives
After completing this course, the reader will be able to: Identify the different types of brainstem glioma in adults and their radiological features.Select the most accurate diagnostic test and propose options for treatment in patients suffering from brainstem gliomas.
CME This article is available for continuing medical education credit at CME.TheOncologist.com
Brainstem gliomas are uncommon in adults and account for only 1%–2% of intracranial gliomas. They represent a heterogeneous group of tumors that differ from those found in their pediatric counterparts. In adults, a low-grade phenotype predominates, which is a feature that likely explains their better prognosis compared to that in children. Because biopsies are rarely performed, classifications based on the radiological aspect of magnetic resonance imaging results have been proposed to establish treatment strategies and to determine outcomes: (a) diffuse intrinsic low-grade, (b) enhancing malignant glioma, (c) focal tectal gliomas, and (d) exophytic gliomas. Despite significant advances in neuroradiology techniques, a purely radiological classification remains imperfect in the absence of a histological diagnosis. Whereas a biopsy may often be reasonably avoided in the diffuse nonenhancing forms, obtaining histological proof seems necessary in many contrast-enhanced brainstem lesions because of the wide variety of differential diagnoses in adults. Conventional radiotherapy is the standard treatment for diffuse intrinsic low-grade brainstem gliomas in adults (the median survival is 5 years). In malignant brainstem gliomas, radiotherapy is the standard treatment. However, the possible benefit of combined radiotherapy and chemotherapy (temozolomide or other agents) has not been thoroughly evaluated in adults. The role of anti-angiogenic therapies in brainstem gliomas remains to be defined. A better understanding of the biology of these tumors is of primary importance for identifying homogeneous subgroups and for improving therapy options and outcomes.
A characterization of diameter-2-critical graphs with no antihole of length four
Authors: Haynes Teresa , Henning Michael 
Published: March 2012

Abstract
A graph G is diameter-2-critical if its diameter is two and the deletion of any edge increases the diameter. In this paper we characterize the diameter-2-critical graphs with no antihole of length four, that is, the diameter-2-critical graphs whose complements have no induced 4-cycle. Murty and Simon conjectured that the number of edges in a diameter-2-critical graph of order n is at most n
2/4 and that the extremal graphs are complete bipartite graphs with equal size partite sets. As a consequence of our characterization, we prove the Murty-Simon Conjecture for graphs with no antihole of length four.
Gromov hyperbolic cubic graphs
Authors: Pestana Domingo , Rodríguez José , Sigarreta José , Villeta María 
Published: March 2012

Abstract
If X is a geodesic metric space and x
1; x
2; x
3 ∈ X, a geodesic triangle T = {x
1; x
2; x
3} is the union of the three geodesics [x
1
x
2], [x
2
x
3] and [x
3
x
1] in X. The space X is δ-hyperbolic (in the Gromov sense) if any side of T is contained in a δ-neighborhood of the union of the two other sides, for every geodesic triangle T in X. We denote by δ(X) the sharp hyperbolicity constant of X, i.e., δ(X) = inf {δ ≥ 0: X is δ-hyperbolic}. We obtain information about the hyperbolicity constant of cubic graphs (graphs with all of their vertices of degree 3), and prove that for any graph G with bounded degree there exists a cubic graph G* such that G is hyperbolic if and only if G* is hyperbolic. Moreover, we prove that for any cubic graph G with n vertices, we have δ(G) ≤ min {3n/16 + 1; n/4}. We characterize the cubic graphs G with δ(G) ≤ 1. Besides, we prove some inequalities involving the hyperbolicity constant and other parameters for cubic graphs.
Physical implications of Fisher-information’s scaling symmetry
Authors: Flego Silvina , Plastino Angelo , Plastino Angel 
Published: March 2012

Abstract
We study the scaling properties of Fisher’s information measure (FIM) and show that from these one can straightforwardly deduce significant quantum-mechanical results. Specifically, we investigate the scaling properties of Fisher’s measure I and encounter that, from the concomitant operating rules, several interesting, albeit known, results can be derived. This entails that such results can be regarded as pre-configured by the conjunction of scaling and information theory. The central notion to be arrived at is that scaling entails that I must obey a certain partial differential equation (PDE). These PDE-solutions have properties that enable the application of a Legendre-transform (LT). The conjunction PDE+LT leads one to obtain several quantum results without recourse to the Schrödinger’s equation.
Self-assembly mechanism in colloids: perspectives from statistical physics
Authors: Giacometti Achille 
Published: March 2012

AbstractMotivated by recent experimental findings in chemical synthesis of colloidal particles, we draw an analogy between self-assembly processes occurring in biological systems (e.g. protein folding) and a new exciting possibility in the field of material science. We consider a self-assembly process whose elementary building blocks are decorated patchy colloids of various types, that spontaneously drive the system toward a unique and predetermined targeted macroscopic structure. To this aim, we discuss a simple theoretical model — the Kern-Frenkel model — describing a fluid of colloidal spherical particles with a pre-defined number and distribution of solvophobic and solvophilic regions on their surface. The solvophobic and solvophilic regions are described via a short-range square-well and a hard-sphere potentials, respectively. Integral equation and perturbation theories are presented to discuss structural and thermodynamical properties, with particular emphasis on the computation of the fluid-fluid (or gas-liquid) transition in the temperaturedensity plane. The model allows the description of both one and two attractive caps, as a function of the fraction of covered attractive surface, thus interpolating between a square-well and a hard-sphere fluid, upon changing the coverage. By comparison with Monte Carlo simulations, we assess the pros and the cons of both integral equation and perturbation theories in the present context of patchy colloids, where the computational effort for numerical simulations is rather demanding.
Synthesis of conjugated (E,E)-1,3-diene-containing troponoid-based compounds
Authors: Gao Wen-Tao , Yan Yan , Li Yang 
Published: March 2012

AbstractThrough exploration of the electrophilic substitution reaction of 3-((2E,4E)-5-phenylpenta-2,4-dienoyl)-2-hydroxy-2,4,6-cycloheptatrien-1-one (3-((2E,4E)-5-phenylpenta-2,4-dienoyl)tropolone) with halogen and diazonium salts as well as the nucleophilic cyclisation reaction with hydroxylamine hydrochloride and substituted phenylhydrazine hydrochlorides by employing our reliable methods, we have synthesised a series of new (E,E)-1,3-diene-bearing troponoid-based compounds. All the newly synthesised molecules represent an issue of great interest, since the presence of conjugated 1,3-diene moiety can be developed further via other reactions.
Predictive Capability of Bedload Equations Using Flume Data
Authors: Talukdar S. , Kumar Bimlesh , Dutta S. 
Published: March 2012

Predictive Capability of Bedload Equations Using Flume DataThe study on bedload transport behaviour is widely explored from the last few decades and many semiempirical or empirical equilibrium transport equations are developed. The phenomenon is a very complex due to its varied physical properties like velocity, depth, slope, particle size in the alluvial system. In practical applications, these formulae have appreciable deviation from each other in derivation and also their ranges of applications are different. Here, bedload transports have been categorized into moderate bedload transport and intense bedload transport depending upon the Einstein bedload transport parameter. Based on large database of different bedload measurements, a comparative analysis has been performed to ascertain prediction ability of different bedload equations based on various statistical criteria such as the coefficient of determination, Nash-Sutcliffe coefficient and index of agreement. It has been found that equations based on shear stress have worked better than other approaches (discharge, probabilistic and regression) for flume observations.
Hydrodynamic and kinetic study of an elution of a high viscosity liquid from the sand bed using eluent of low viscosity
Authors: Sęk Jerzy , Błaszczyk Mariola , Bartos Michał 
Published: March 2012

Hydrodynamic and kinetic study of an elution of a high viscosity liquid from the sand bed using eluent of low viscosity
The study was aimed to determine the hydrodynamic of water seepage through a porous bed saturated with different amounts of high viscosity liquids. An attempt was made to describe the process of seepage through beds saturated with oils using the theory of outflow of a liquid from the tank. It was assumed that the discharge coefficient will represent changes of flow resistance during the process. It was found that the dependence of this factor on time is linear. In the second part of this work kinetics of the seepage process was investigated. Dependence of oil concentrations, eluted from the deposit with the flowing water, on time has been evaluated. Thanks to these studies it was possible to determine the effectiveness of an elution of high viscosity liquids from porous beds using water as the washing out liquid.
Effects of stent-graft geometry and blood hematocrit on hemodynamic in Abdominal Aortic Aneurysm
Authors: Polańczyk Andrzej , Podyma Marek , Stefańczyk Ludomir , Zbiciński Ireneusz 
Published: March 2012

Effects of stent-graft geometry and blood hematocrit on hemodynamic in Abdominal Aortic Aneurysm
CFD technique was used to determine the effect of a stent-graft spatial configuration and hematocrit value on blood flow hemodynamic and the risk of a stent-graft occlusion. Spatial configurations of an endovascular prosthesis placed in Abdominal Aortic Aneurysm (AAA) for numerical simulations were developed on the basis of AngioCT data for 10 patients. The results of calculations showed that narrows or angular bends in the prosthesis as well as increased hematocrit affects blood flow reducing velocity and WSS which might result in thrombus development.
Impact of bioreactor scale on lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture
Authors: Pawlak Marta , Bizukojć Marcin , Ledakowicz Stanisław 
Published: March 2012

Impact of bioreactor scale on lovastatin biosynthesis by Aspergillus terreus ATCC 20542 in a batch culture
Biosynthesis of lovastatin (a polyketide metabolite of Aspergillus terreus) in bioreactors of different working volume was studied to indicate how the change of scale of the process influences the formation of this metabolite. The experiments conducted in shake flasks of 150 ml working volume allowed to obtain lovastatin titres at the level of 87.5 mg LOV l-1, when two carbon sources, namely lactose and glycerol were used. The application of the same components in a large stirred-tank bioreactor of 5.3-litre working volume caused a decrease of lovastatin production by 87% compared to the shake flask culture. The deficiency of nitrogen in this bioreactor did not favour the formation of lovastatin, in contrast to the small bioreactor of 1.95-litre working volume, in which lovastatin titres comparable to those in the shake flasks could be achieved, when organic nitrogen concentration was two-fold decreased. When the control of pH and/or pO2 was used simultaneously, an increase in lovastatin production was observed in the bioreactors. However, these results were still slightly lower than lovastatin titres obtained in the shake flasks.
Analysis of the breakage rate function for selected process parameters in quartzite milling
Authors: Olejnik Tomasz 
Published: March 2012

Analysis of the breakage rate function for selected process parameters in quartzite milling
The paper presents the results of studies on quartzite milling in a ball mill. The milling was conducted in a batch system, for diversified compositions of balls. The milling product was subjected to granulometrical, morphological and strength analyses. On the basis of the developed Reid's theory and using the Austin-Gardner equation, a form of the function circumscribing the specific rate of comminution of selected size fractions was determined. The values of the breakage rate function bi, j for the mill's apparatus conditions were determined. The impact was investigated for a variable number of grinding media contact points on the values of specific rate S and the values of the breakage rate function bi, j. Furthermore, the values of coefficients occurring in the equations circumscribing the specific rate of milling S and breakage parameter bi, j were determined.
Charisma and Communion
Authors: Araújo Vera 
Published: March 2012

AbstractIn the context of reflections on modernity, an increasingly widespread belief seems to be emerging: the subject at which it is necessary to direct our attention, to which to throw a lifeline as it were, is the concrete and real human being, alone and at the same time besieged by increasingly tight and numerous systemic schemes. Are the “human subject” and his social context only undergoing a deep transformation, or are they actually in danger? This “new” knowledge involves all the humanistic and social sciences, such as philosophy, anthropology, psychology, economics, political science, and theology, in a sort of fusion and pact for mankind.Great spiritualities include life experiences and ideas that reverberate on everyday life, lifestyles, and culture. From the very beginning, Chiara Lubich’s spirituality, is based on two fundamental concepts: unity and forsaken Jesus, has been perceived as a new way to know God, but also as an idea that is able to renew human life, as well as to penetrate social and cultural realities.
The Gift of Oneself from the Perspective of New Readings of “The Gift” by Marcel Mauss
Authors: Malatesta Freitas Maria Do Socorro 
Published: March 2012

Abstract
The Gift: Forms and Functions of Exchange in Archaic Societies, by Marcel Mauss, is an important reference in Social Sciences for thinking about the theme of the gift, proposed in this congress. This brief work has as goal to present a rereading of The Gift by contemporary authors that try to think today’s society under this perspective. It’s a literature review of books and articles by Allain Caillé, Jacques Godbout and some Brazilian authors: Eric Sabourin, Marcos Lanna, Paulo Henrique Martins and Jorge Luiz Villela.
It is important to emphasize, according to Caillé, 1998, that “the paradigm of the gift is not a machine for blowing solutions, but for inspiring questions”.
Masculinity and Femininity: Essential to the Identity of the Human Person
Authors: O'Donnell Nancy 
Published: March 2012

Abstract
The title of this congress begins with the word “identity”. It also includes the word “reciprocity,” which indicates a form of relationship and finally, “gift of self”. This would lead us to conclude that the identity of the human person has something to do with reciprocity and that reciprocity involves giving of oneself to others. This talk will attempt to shed light on how the concept of gender might in some way be incorporated into these three concepts.
Defining what constitutes the identity of the human person has been explored, and attempts to define it have been made by every major theorist in the field of psychology. At a previous Psychology and Communion congress one of the talks (Ionata, 2002) spoke of loving and being loved in return as the basic foundation of human identity. In that presentation we find the following observation: “The identity of the human person can be compared to the identity of a book: we know where and when it was printed; but the author is certainly not the publishing house, nor is the typesetter who prepared the text…The same is true for us human beings: we know the time and date of birth. But who is author?” (31).
We ask ourselves, therefore: what lies at the core of the identity of this being who is born at a certain time on a certain date?
Before proceeding, I think it is important to note that the basic idea regarding the identity of the human person, as we have defined and understood it from the inception of psychology and communion and explored in previous encounters, remains unchanged. I will use a quote of Chiara Lubich here that perhaps many of you know but which can serve the purpose of laying the foundation for what follows: Human beings are “(…) all equal but distinct. To each person [God] gave his own beauty so that they would be desirable and lovable by others; and so that in love (the common substance in which they recognize themselves as one and see themselves in each other) they would be recomposed into the One who had created them with his Light, which is Himself.”
Now we ask ourselves: What exactly is this “beauty” that Chiara is speaking of? What are the components, if you will, of our identity that makes us “… desirable and lovable by others…”?
Paradigm of Unity as a Prospect for Research and Treatment in Psychology
Authors: Biela Adam 
Published: March 2012

Abstract
The purpose of this paper is to show the methodological power and potentiality of the concept paradigm of unity introduced originally in the ceremony on the occasion of honoring Chiara Lubich with the doctor honoris causa title by the Catholic University of Lublin in 1996. Originally this conception was used to suggest the societal activity of Chiara Lubich in building, via the Focolari movement, psychosocial infrastructures for unity in various social domains, (for example in the economy of communion, in politics (politicians for unity project), in public media (journalists for unity), in ecumenism and inter-religious contacts (ecumenical and inter-religion Focolari Centers) This conception is a kind of a great inspiration (a kind of Copernican revolution in the social sciences) which would motivate the social sciences to build their own research paradigm of a type of mental and methodological power and potentiality which could give a new vision of social world (as Copernicus did in natural sciences (Biela, 1996, 2006)). Thomas Kuhn (1962) regarded the Copernician revolution as the one which, in the history of science, best illustrates the nature of scientific revolution. The essence of paradigm in a Kuhnian sense is a mentality change in its nature. Copernicus had to change the well-established geocentric system which functioned not only in the science of his day but also in culture, tradition, social perception, and even in the mentality of religious and political authorities. And he did it in a well prepared empirical, methodological and psychological way.
In a similar way Chiara Lubich created by her social acting a revolutionary inspiration for building paradigm in social science She decided in an extremely difficult and risky situation in 1944 in Trento not only to escape from her own life emergency but she with her friends made a decision to help other people who were in a much more difficult situation to survive. She decided to take a war bombing risk to be with lost children and older people who were in need. It was a practical building of the unity with the real people who were in need. This kind of experience rediscovered the community as a model for the real life and made a concretization and clarification of the charisma of the unity. However, the development of this charisma shows that it is simply a concrete and practical actualization of the new vision of social, economic, political and religious relationships which advises, recommends, suggests, and promotes the unity with others persons (Lubich, 2007).
The Present Moment and Giving Oneself as a Gift
Authors: Molinari Enrico , Spatola Chiara , Cappella Emanuele , Castelnuovo Gianluca 
Published: March 2012

Abstract
The contemporary individual is immersed in a reality characterized by a rapid sequence of stimuli and actions and he is often unable to fully live the present moment.
Several authors in the field of psychology have discussed on the individual’s ability to live his own experience in the present moment, each highlighting some peculiar aspects and potential of this concept within their models.
The major aim of the present article is to discuss these different psychological perspectives moving from more traditional models such ad Gestalt psychotherapy and Psychoanalysis to contemporary approaches such as Mindfulness-based Cognitive therapy (Kabat-Zinn) and Acceptance and Commitment Therapy (Hayes), and to highlight some points of convergence between such approaches and Chiara Lubich’s thought. In fact Lubich investigated the concept of the present moment from a spiritual perspective, drawing on the life experience inspired by the charisma of unity.