bluuebunny/crossref_metadata_2025_split huggingface dataset:
A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics
Authors: Porcu Giampiero , Wilson Cathal , Di Giandomenico Daniele , Ragnini-Wilson Antonella 
Published: July 2010

Abstract

Background
Farnesyltransferase inhibitors (FTIs) are anticancer agents developed to inhibit Ras oncoprotein activities. FTIs of different chemical structure act via a conserved mechanism in eukaryotic cells. They have low toxicity and are active on a wide range of tumors in cellular and animal models, independently of the Ras activation state. Their ultimate mechanism of action, however, remains undetermined. FTase has hundred of substrates in human cells, many of which play a pivotal role in either tumorigenesis or in pro-survival pathways. This lack of knowledge probably accounts for the failure of FTIs at clinical stage III for most of the malignancies treated, with the notable exception of haematological malignancies. Understanding which cellular pathways are the ultimate targets of FTIs in different tumor types and the basis of FTI resistance is required to improve the efficacy of FTIs in cancer treatment.

Results
Here we used a yeast-based cellular assay to define the transcriptional changes consequent to FTI peptidomimetic administration in conditions that do not substantially change Ras membrane/cytosol distribution. Yeast and cancer cell lines were used to validate the results of the network analysis. The transcriptome of yeast cells treated with FTase inhibitor I was compared with that of untreated cells and with an isogenic strain genetically inhibited for FTase activity (Δram1). Cells treated with GGTI-298 were analyzed in a parallel study to validate the specificity of the FTI response. Network analysis, based on gene ontology criteria, identified a cell cycle gene cluster up-regulated by FTI treatment that has the Aurora A kinase IPL1 and the checkpoint protein MAD2 as hubs. Moreover, TORC1-S6K-downstream effectors were found to be down-regulated in yeast and mammalian FTI-treated cells. Notably only FTIs, but not genetic inhibition of FTase, elicited up-regulation of ABC/transporters.

Conclusions
This work provides a view of how FTIs globally affect cell activity. It suggests that the chromosome segregation machinery and Aurora A association with the kinetochore as well as TORC1-S6K downstream effectors are among the ultimate targets affected by the transcriptional deregulation caused by FTI peptidomimetics. Moreover, it stresses the importance of monitoring the MDR response in patients treated with FTIs.
Characterization of the TnsD-attTn7 complex that promotes site-specific insertion of Tn7
Authors: Mitra Rupak , McKenzie Gregory J , Yi Liang , Lee Cherline A , Craig Nancy L 
Published: July 2010

Abstract
The bacterial transposon Tn7 is distinguished by its ability to recognize a specific site called attTn7, and insert just downstream of the highly conserved chromosomal glmS gene. TnsD is one of four transposon-encoded polypeptides (TnsABC+D) required for site-specific insertion of Tn7 into attTn7, and is the target site-selector that binds to a highly conserved sequence in the end of the glmS protein coding region. In this study, we identified important nucleotides within this region that are crucial for TnsD-attTn7 interaction. We also probed the regions of TnsD that interact with attTn7 and found that there are important DNA-binding determinants throughout the entire length of the protein, including an amino-terminal CCCH zinc-finger motif. A key role of TnsD is to recruit the non-sequence specific DNA-binding protein TnsC to attTn7; TnsC also interacts with and controls both the TnsA and TnsB subunits of the Tn7 transposase. TnsC stimulates the binding of TnsD to attTn7 in vivo, and TnsCD and TnsD can also interact in the absence of DNA and localize their interaction domains to the N-terminal region of each protein.
Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study
Authors: Ghabach Bassam , Anderson William F , Curtis Rochelle E , Huycke Mark M , Lavigne Jackie A , Dores Graça M 
Published: July 2010

Abstract
Introduction
Adenoid cystic carcinoma of the breast (breast-ACC) is a rare and special type of basal-like tumor for which scant population-based descriptive data exist. We sought to provide new population-based information on breast-ACC incidence, relative survival, and associated cancer risk in the United States.

Methods
Using data from the Surveillance, Epidemiology and End Results Program, we calculated age-adjusted incidence rates (IRs), IR ratios (IRRs), and relative survival for breast-ACC, and standardized incidence ratios (SIRs) for other cancers.

Results
Overall 338 women (IR = 0.92/1 million person-years) were diagnosed with breast-ACC during 1977 to 2006. Blacks had 39% lower IRs than Whites (IRR = 0.61, 95% confidence interval = 0.37 to 0.96), and IRs remained constant over the 30-year period. Ninety-five percent of cases presented with localized stage (n = 320; IR = 0.87), and the highest IRs were observed for estrogen receptor (ER)-negative/progesterone receptor (PR)-negative tumors (IR = 0.56). Like other typically ER-negative tumors, age-specific IRs increased until midlife and then plateaued. Five-year, 10-year, and 15-year relative survival was 98.1%, 94.9%, and 91.4%, respectively. The risk of female breast cancer was not increased following (SIR = 0.89, 95% confidence interval = 0.43 to 1.64) or preceding (SIR = 0.71, 95% confidence interval = 0.28 to 1.46) breast-ACC. Similarly, no association was observed for breast-ACC and risk of all other cancers combined, solid tumors, or lymphohematopoietic malignancies.

Conclusions
Breast-ACC among women is characterized by ER-negative/PR-negative expression, rare regional lymph node involvement, a favorable prognosis with excellent survival, and absence of associated cancers. These findings reinforce the importance of tailored treatments for breast-ACC and lend credence to the apparent heterogeneity of basal-like breast cancers.
Providing Care for Underserved Patients: Periodontists' and Periodontal Residents' Educational Experiences, Attitudes, and Behaviors
Authors: Garfinkle Adam J. , Richards Philip S. , Inglehart Marita R. 
Published: July 2010

Background: Patients with special health care needs (SHCNs) and patients from underrepresented minority and/or low socioeconomic backgrounds are more likely to have problems accessing oral health care services. The objectives of this study are: 1) to explore how well the dental education of periodontists prepared them to treat these underserved patients, 2) to assess related professional attitudes and confidence when treating these patients as well as professional behaviors, and 3) whether educational experiences are related with attitudes, confidence, and behaviors in this context.Methods: Survey data were collected from a randomly selected sample of 291 members of the American Academy of Periodontology (AAP) and 64 periodontal residents.Results: Overall, large percentages of residents agreed that their predoctoral and graduate dental educations had prepared them well to treat patients with special needs (predoctoral education: 58%; clinical graduate education: 45%; and classroom‐based graduate education: 37%), from different ethnic/racial backgrounds (predoctoral education: 74%; clinical graduate education: 74%; and classroom‐based graduate education: 60%), and on Medicaid (predoctoral education: 60%; clinical graduate education: 61%; and classroom‐based graduate education: 42%). Practicing clinicians were least positive about their educations. Students were more positive about treating patients on Medicaid and pro bono cases than practicing clinicians. However, the two groups did not differ in their confidence when treating underserved patients. The quality of predoctoral and graduate educations regarding underserved patients correlates with the attitudes, confidence, and behaviors of providers concerning providing care for these patients.Conclusions: The findings of this study stress the importance of preparing future periodontists in their predoctoral and graduate programs for providing care for underserved patients such as patients with SHCNs. The better that dental education prepares future periodontists to provide care for underserved patients, the more confident periodontists will be when encountering these patients in their own practices and the more likely they will be to contribute to reducing disparities in oral health care access in the United States by treating these patients.
Effectiveness of Interferential Current Therapy in the Management of Musculoskeletal Pain: A Systematic Review and Meta-Analysis
Authors: Fuentes Jorge P. , Armijo Olivo Susan , Magee David J. , Gross Douglas P. 
Published: July 2010

BackgroundInterferential current (IFC) is a common electrotherapeutic modality used to treat pain. Although IFC is widely used, the available information regarding its clinical efficacy is debatable.PurposeThe aim of this systematic review and meta-analysis was to analyze the available information regarding the efficacy of IFC in the management of musculoskeletal pain.Data SourcesRandomized controlled trials were obtained through a computerized search of bibliographic databases (ie, CINAHL, Cochrane Library, EMBASE, MEDLINE, PEDro, Scopus, and Web of Science) from 1950 to February 8, 2010.Data ExtractionTwo independent reviewers screened the abstracts found in the databases. Methodological quality was assessed using a compilation of items included in different scales related to rehabilitation research. The mean difference, with 95% confidence interval, was used to quantify the pooled effect. A chi-square test for heterogeneity was performed.Data SynthesisA total of 2,235 articles were found. Twenty studies fulfilled the inclusion criteria. Seven articles assessed the use of IFC on joint pain; 9 articles evaluated the use of IFC on muscle pain; 3 articles evaluated its use on soft tissue shoulder pain; and 1 article examined its use on postoperative pain. Three of the 20 studies were considered to be of high methodological quality, 14 studies were considered to be of moderate methodological quality, and 3 studies were considered to be of poor methodological quality. Fourteen studies were included in the meta-analysis.ConclusionInterferential current as a supplement to another intervention seems to be more effective for reducing pain than a control treatment at discharge and more effective than a placebo treatment at the 3-month follow-up. However, it is unknown whether the analgesic effect of IFC is superior to that of the concomitant interventions. Interferential current alone was not significantly better than placebo or other therapy at discharge or follow-up. Results must be considered with caution due to the low number of studies that used IFC alone. In addition, the heterogeneity across studies and methodological limitations prevent conclusive statements regarding analgesic efficacy.
The Migration of T Cells in Response to Influenza Virus Is Altered in Neonatal Mice
Authors: Lines J. Louise , Hoskins Samantha , Hollifield Melissa , Cauley Linda S. , Garvy Beth A. 
Published: July 2010

AbstractInfluenza virus is a significant cause of mortality and morbidity in children; however, little is known about the T cell response in infant lungs. Neonatal mice are highly vulnerable to influenza and only control very low doses of virus. We compared the T cell response to influenza virus infection between mice infected as adults or at 2 d old and observed defective migration into the lungs of the neonatal mice. In the adult mice, the numbers of T cells in the lung interstitia peaked at 10 d postinfection, whereas neonatal T cell infiltration, activation, and expression of TNF-α was delayed until 2 wk postinfection. Although T cell numbers ultimately reached adult levels in the interstitia, they were not detected in the alveoli of neonatal lungs. Instead, the alveoli contained eosinophils and neutrophils. This altered infiltrate was consistent with reduced or delayed expression of type 1 cytokines in the neonatal lung and differential chemokine expression. In influenza-infected neonates, CXCL2, CCL5, and CCL3 were expressed at adult levels, whereas the chemokines CXCL1, CXCL9, and CCL2 remained at baseline levels, and CCL11 was highly elevated. Intranasal administration of CCL2, IFN-γ, or CXCL9 was unable to draw the neonatal T cells into the airways. Together, these data suggest that the T cell response to influenza virus is qualitatively different in neonatal mice and may contribute to an increased morbidity.
Chryseomonas luteola from Bile Culture in an Adult Male with Severe Jaundice
Authors: De Anuradha S , Salunke Parul P , Parikh Harshal R , Baveja Sujata M 
Published: July 2010

ABSTRACTA 60-year-old male was admitted in this hospital with severe jaundice, who had open cholecystectomy done 2 months ago. ERCP was performed and bile was sent for culture. It grew Chryseomonas luteola in pure culture. He underwent hepaticojejunostomy after 1 month. Total bilirubin improved gradually. His condition was stable on discharge. Prompt diagnosis of non-fermenters is required, as some of them are resistant to multiple antibiotics. Clinicians have to be made aware of the pathogenic role of C. luteola and its resistance to ampicillin and cephalosporins.
Pervaporative Dehydration of Alcohols by Carbonized Kapton® Polyimide
Authors: Sungpet A. , Prapruddivongs C. 
Published: July 2010

AbstractKapton® polyimide was carbonized at 873, 1073 and 1273 K with a heating rate of 1, 3 and 5 K min–1 and applied to the dehydration of methanol, ethanol and isopropanol by pervaporation. Lowering the heating rate or increasing the carbonization temperature resulted in higher selectivity and a decrease in permeability. X‐ray diffraction data revealed that when carbonized at high temperature or with a low heating rate, the membrane had lower interplanar spacing, which corresponded to a reduction in pore size. It was also found that the carbonization temperature had a greater influence on the membrane structure than the heating rate. A comparison between permeability observed from single‐component and bi‐component feeds indicated that the separation mechanism involved more than molecular sieving alone.
Towards a Molecular Understanding of Cation–Anion Interactions—Probing the Electronic Structure of Imidazolium Ionic Liquids by NMR Spectroscopy, X‐ray Photoelectron Spectroscopy and Theoretical Calculations
Authors: Cremer Till , Kolbeck Claudia , Lovelock Kevin R. J. , Paape Natalia , Wölfel René , Schulz Peter S. , Wasserscheid Peter , Weber Henry , Thar Jens , Kirchner Barbara , Maier Florian , Steinrück Hans‐Peter 
Published: July 2010

AbstractTen [C8C1Im]+ (1‐methyl‐3‐octylimidazolium)‐based ionic liquids with anions Cl−, Br−, I−, [NO3]−, [BF4]−, [TfO]−, [PF6]−, [Tf2N]−, [Pf2N]−, and [FAP]− (TfO=trifluoromethylsulfonate, Tf2N=bis(trifluoromethylsulfonyl)imide, Pf2N=bis(pentafluoroethylsulfonyl)imide, FAP=tris(pentafluoroethyl)trifluorophosphate) and two [C8C1C1Im]+ (1,2‐dimethyl‐3‐octylimidazolium)‐based ionic liquids with anions Br− and [Tf2N]− were investigated by using X‐ray photoelectron spectroscopy (XPS), NMR spectroscopy and theoretical calculations. While 1H NMR spectroscopy is found to probe very specifically the strongest hydrogen‐bond interaction between the hydrogen attached to the C2 position and the anion, a comparative XPS study provides first direct experimental evidence for cation–anion charge‐transfer phenomena in ionic liquids as a function of the ionic liquid’s anion. These charge‐transfer effects are found to be surprisingly similar for [C8C1Im]+ and [C8C1C1Im]+ salts of the same anion, which in combination with theoretical calculations leads to the conclusion that hydrogen bonding and charge transfer occur independently from each other, but are both more pronounced for small and more strongly coordinating anions, and are greatly reduced in the case of large and weakly coordinating anions.
ChemInform Abstract: The Indide‐Hydride Ba9[In]4[H]: Synthesis, Crystal Structure, NMR Spectroscopy, Chemical Bonding.
Authors: Wendorff Marco , Scherer Harald , Roehr Caroline 
Published: July 2010

AbstractThe title compound is prepared from stoichiometric mixtures of the elements using the inherent hydrogen content of commercial elemental barium as hydrogen source (Ta crucible, 1670 K) and characterized by single crystal XRD, 1H MAS NMR spectroscopy, and DFT calculations.
ChemInform Abstract: Optical Properties of the Complex Perovskite Ceramic Oxide Ba2YZrO6‐d.
Authors: Kumar V. R. , Wariar P. R. S. , Koshy J. 
Published: July 2010

AbstractNanocrystalline Ba2YZrO6‐d is prepared by auto‐ignition combustion of an aqueous HNO3 solution of Ba(NO3)2, Y2O3, ZrOCl2, citric acid, and NH4OH, and characterized by powder XRD, TEM, and UV/VIS spectroscopy.
ChemInform Abstract: Synthesis, Crystal and Electronic Structure of the Nitridoaluminosilicate Ca5[Si2Al2N8].
Authors: Ottinger Frank , Cuervo‐Reyes Eduardo , Nesper Reinhard 
Published: July 2010

AbstractThe new title compound is prepared by reaction of Ca3N2 with elementary Al and Si (Nb ampule, Ar, 1280 °C, 35 h).
ChemInform Abstract: A Study on AB2O6 Compounds. Part 1. Synthesis, Structure, Magnetic Properties and 151Eu Moessbauer Spectroscopic Data of EuNb2O6.
Authors: Beck Horst P. , Seup‐Ra Hyun , Haberkorn Robert , Kohlmann Holger , Eul Matthias , Harmening Thomas , Poettgen Rainer 
Published: July 2010

AbstractThe title compound is prepared from a stoichiometric mixture of Eu2O3, Nb2O5, and NbO2 (Mo crucible, 1200 °C, 44 h) and characterized by powder XRD, Moessbauer spectroscopy, and magnetic measurements.
ChemInform Abstract: Clean and Convenient One‐Pot Synthesis of 4‐Hydroxycoumarin and 4‐Hydroxy‐2‐quinolinone Derivatives.
Authors: Gao Wen‐Tao , Hou Wen‐Duan , Zheng Mei‐Ru , Tang Li‐Jun 
Published: July 2010

AbstractAdvantages of the title procedure are simple experimental and product isolation procedures.
ChemInform Abstract: Copper‐Catalyzed Diacetoxylation of Olefins Using PhI(OAc)2 as Oxidant.
Authors: Seayad Jayasree , Seayad Abdu Majeed , Chai Christina L. L. 
Published: July 2010

AbstractAromatic and aliphatic olefins as well as terminal and internal olefins are converted into the corresponding vicinal diacetoxy compounds with good yields and low to moderate diastereoselectivities.
ChemInform Abstract: Synthesis and Application of a New Fluorous‐Tagged Ammonia Equivalent.
Authors: Nielsne Simon D. , Smith Garrick , Begtrup Mikael , Kristensen Jesper L. 
Published: July 2010

AbstractA novel fluorous‐phase strategy for the synthesis of N‐alkylated amides, ureas, carbamates, and sulfonamides employs hydroxylamine (III) as ammonia surrogate.
ChemInform Abstract: Iridium‐Catalyzed, Silyl‐Directed Borylation of Nitrogen‐Containing Heterocycles.
Authors: Robbins Daniel W. , Boebel Timothy A. , Hartwig John F. 
Published: July 2010

AbstractThe one‐pot method involves the ruthenium‐catalyzed dehydrogenative coupling of indoles or N‐heterocycles such as carbazole,tetrahydroquinoline, and dibenzothiazines with a dihydrosilane or dimethylchlorosilane to give the N‐silylated derivatives, which undergo an iridium‐catalyzed silyl‐directed borylation reaction to afford after desilylation the selectively borylated heterocycles.
ChemInform Abstract: Zinc‐Mediated Alkylation and Acylation of 1,3‐Dicarbonyl Compounds.
Authors: Yadav J. S. , Reddy B. V. Subba , Mishra Anand Kumar 
Published: July 2010

AbstractA simple and base‐free method for the monoalkylation and ‐acylation of active methylene compounds such as 1,3‐diesters and β‐ketoesters is presented.
ChemInform Abstract: A Dimethylsulfonium Methylide Mediated Highly Regioselective Olefination of Conjugated Polyolefin 1,1‐Dioates to Conjugated Polyene‐2‐yl‐malonates and Their Applications in Diels—Alder Reactions.
Authors: Singh Rekha , Ghosh Sunil K. 
Published: July 2010

AbstractConjugated polyene‐2‐yl‐malonates smoothly undergo regio‐ and stereoselective Diels—Alder reaction with dienophiles to afford cycloadducts such as (XVIII).
ChemInform Abstract: Hydroformylation Reaction of Alkylidenecyclopropane Derivatives: A New Pathway for the Formation of Acyclic Aldehydes Containing Quaternary Stereogenic Carbons.
Authors: Simaan Samah , Marek Ilan 
Published: July 2010

AbstractThe rhodium‐catalyzed title reaction is highly selective and leads to the exclusive formation of the expected linear γ,δ‐unsaturated aldehydes.
ChemInform Abstract: Flavoring and Odorant Thiols from Renewable Natural Resources by InIII‐Catalyzed Hydrothioacetylation and Lipase‐Catalyzed Solvolysis.
Authors: Dia Reine‐Marie , Belaqziz Rim , Romane Abderrahmane , Antoniotti Sylvain , Dunach Elisabet 
Published: July 2010

AbstractA chemoenzymatic deacetylation of thioacetic esters with a variety of lipases in buffered aqueous systems is developed.
ChemInform Abstract: Exploring the One‐Pot C‐Acylation of Cyclic 1,3‐Diones with Unactivated Carboxylic Acid.
Authors: Goncalves Sylvie , Nicolas Marc , Wagner Alain , Baati Rachid 
Published: July 2010

AbstractA broad spectrum of carboxylic with various functionalities can be used to prepare the desired subunits of natural products such as chelocardin, tralkoxydim and usnic acid.
ChemInform Abstract: Novel Synthetic Methodologies. Part 197. A Rapid and Efficient Synthesis of Allyl Iodides from Baylis—Hillman Adducts: A Facile Synthesis of Semiplenamide D.
Authors: Das Biswanath , Srinivas Yallamalla , Sudhakar Chithaluri , Damodar Kongara , Reddy Parigi Raghavendra 
Published: July 2010

AbstractA highly efficient method for the synthesis of allyl iodides from Baylis—Hillman adducts (I) is developed and successfully utilized for the preparation of the natural bioactive fatty acid amide, semiplenamide D (III).
ChemInform Abstract: The Ionic Liquid [bmim]Br as an Alternative Medium for the Catalytic Cleavage of Aromatic C—F and C—Cl Bonds.
Authors: Prikhod'ko Sergey A. , Adonin Nicolay Yu. , Parmon Valentin N. 
Published: July 2010

AbstractHydrodehalogenation of C—F and C—Cl bonds of highly fluorinated arenes is achieved using zinc in aqueous [bmim]Br.
ChemInform Abstract: Efficient Reducing System Based on Iron for Conversion of Nitroarenes to Anilines.
Authors: Xiao Zhu‐Ping , Wang Ying‐Chun , Du Gao‐Yu , Wu Jun , Luo Tao , Yi Shou‐Fu 
Published: July 2010

AbstractThe method is especially useful for the reduction of aromatic nitro compounds with poor solubility in ethanol.
ChemInform Abstract: A Facile and Efficient Synthesis of β‐Amino Alcohols Using 2,2,2‐Trifluoroethanols as a Metal‐Free and Reusable Medium.
Authors: Khaksar Samad , Heydari Akbar , Tajbakhsh Mahmood , Bijanzadeh Hamid Reza 
Published: July 2010

AbstractEpoxides (I) and (IV) undergo ring‐opening reactions with aliphatic and aromatic amines (II) as nucleophiles under mild conditions to furnish the corresponding β‐amino alcohols in high yields and regioselectivity.
ChemInform Abstract: Water as the Reaction Medium for Multicomponent Reactions Based on Boronic Acids.
Authors: Candeias Nuno R. , Cal Pedro M. S. D. , Andre Vania , Duarte M. Teresa , Veiros Luis F. , Gois Pedro M. P. 
Published: July 2010

AbstractPetasis‐borono‐Mannich reaction, using structurally different aldehydes such as salicylaldehyde, glyoxalic acid and glycoaldehyde is developed.
ChemInform Abstract: The Allylic Nucleophilic Substitution of Morita—Baylis—Hillman Acetates with Isocyanides: A Facile Synthesis of Trisubstituted Olefins.
Authors: Yadav J. S. , Reddy B. V. Subba , Singh Ashutosh Pratap , Majumder Nilanjan 
Published: July 2010

AbstractOptimized conditions allow a clean reaction of the title acetates with TosMIC.
ChemInform Abstract: Aminodefluorination of 2‐X‐Pentafluoro‐1,4‐naphthoquinones (X: NHnBu, NEt2, and OMe).
Authors: Troshkova Nadezhda M. , Goryunov Leonid I. , Gatilov Yurij V. , Nevinsky Georgy A. , Shteingarts Vitalij D. 
Published: July 2010

AbstractAminodefluorination of 2‐butylamino‐ and 2‐diethylaminopentafluoronaphthoquinone mainly occurs at the 6‐ or 8‐positions, cf.