bluuebunny/crossref_metadata_2025_split huggingface dataset:
Allogenic hematopoietic stem cell transplantation in an Iranian patient with osteopetrosis caused by carbonic anhydrase II deficiency: A case report
Authors: Shamsian Bibi Shahin , Momtazmanesh Nader , Saneifard Hedyeh , Tabatabaei Seyed Mohammad Taghi Hosseini , Jafari Mohammadreza , pour Zahra Khafaf , Al‐Hussieni Kawthar Jasim Mohammad Rida , Jamee Mahnaz , Kamfar Sharareh 
Published: April 2024

AbstractBackgroundOsteopetrosis is a group of geneticall heterogeneous disorders resulting from impaired osteoclast function and bone resorption. The identification of specific genetic mutations can yield important prognostic and therapeutic implications. Herein, we present the diagnosis and successful application of hematopoietic stem cell transplantation (HSCT) in a patient with osteopetrosis caused by carbonic anhydrase II deficiency (Intermediate osteopetrosis).Case PresentationHerein, we describe a 2.5‐year‐old male patient born to consanguineous parents who presented at 8‐month‐old with hydrocephaly, brain shunt, and developmental delay. Later at 9 months old, he was found to have eye disorder such as nystagmus, fracture of the elbow, abnormal skeletal survey, normal cell blood count (CBC), and severe hypocellularity in the bone marrow. Further evaluation showed renal tubular acidosis type 2. Whole‐exome sequencing revealed a pathogenic homozygous variant in intron 2 of the carbonic anhydrase 2 gene (CA2) gene (c.232 + 1 G>T). The diagnosis of intermediate autosomal recessive osteopetrosis was established, and allogenic HSCT from his mother, a full‐matched related donor (MRD), was planned. The conditioning regimen included Busulfan, Fludarabine, and Rabbit anti‐thymocyte globulin. Cyclosporine and Mycophenolate Mofetil were used for graft‐versus‐host‐disease prophylaxis. He Engrafted on day +13, and 95% chimerism was achieved. He is currently doing well without immunosuppressive therapy, now 12 months post HSCT, with normal calcium level and improving visual quality and FISH analysis revealed complete donor chimerism.DiscussionHSCT could be a promising curative treatment for intermediate osteopetrosis and can provide long‐term survival. Ongoing challenges in various aspects of HSCT remain to be addressed.
Causal chain event graphs for remedial maintenance
Authors: Yu Xuewen , Smith Jim Q. 
Published: April 2024

AbstractThe analysis of system reliability has often benefited from graphical tools such as fault trees and Bayesian networks. In this article, instead of conventional graphical tools, we apply a probabilistic graphical model called the chain event graph (CEG) to represent the failures and processes of deterioration of a system. The CEG is derived from an event tree and can flexibly represent the unfolding of asymmetric processes. For this application, we need to define a new class of formal intervention we call remedial to model the causal effects of remedial maintenance. This fixes the root causes of a failure and returns the status of the system to as good as new. We demonstrate that the semantics of the CEG are rich enough to express this novel type of intervention. Furthermore, through the bespoke causal algebras, the CEG provides a transparent framework with which to guide and express the rationale behind predictive inferences about the effects of various types of remedial intervention. A backdoor theorem is adapted to apply to these interventions to help discover when a system is only partially observed.
Hybrid Nanofluids Flow over a Vertical Cylinder with Heat Source/Sink and Prescribed Surface Heat Flux
Authors: Sohut Farizza Haniem , Soid Siti Khuzaimah , Ishak Anuar 
Published: April 2024

This work presents the steady mixed convection in Al2O3-Cu/water hybrid nanofluids along a vertically stretching/shrinking cylinder with the prescribed surface heat flux and the effects of heat source/sink. The governing hybrid nanofluids model was simplified using a similarity transformation. The bvp4c solver in MATLAB software is used to solve the hybrid nanofluids flow problem numerically. It is observed that two outcomes are feasible for the assisting and opposing flow regions as well as stretching and shrinking cases . Besides that, the effects of the dimensionless parameters are analyzed graphically and tabularly. In particular, the critical point is reduced by 3% when the curvature parameter goes from 0 to 0.1 and from 0.1 to 0.2 when the cylinder is stretched. This means that the higher curvature parameter could delay the process of separating the boundary layer. It is noted that the positive heat source will decrease the fluid motions and reduce the shear stress on the surface. Moreover, Al2O3-Cu/water hybrid nanofluids have better performance in heat transfer and velocity of fluid flow than Al2O3/water nanofluids.
Module categories, internal bimodules, and Tambara modules
Authors: Stroiński Mateusz 
Published: April 2024

AbstractWe use the theory of Tambara modules to extend and generalize the reconstruction theorem for module categories over a rigid monoidal category to the nonrigid case. We show a biequivalence between the 2‐category of cyclic module categories over a monoidal category and the bicategory of algebra and bimodule objects in the category of Tambara modules on . Using it, we prove that a cyclic module category can be reconstructed as the category of certain free module objects in the category of Tambara modules on , and give a sufficient condition for its reconstructability as module objects in . To that end, we extend the definition of the Cayley functor to the nonclosed case, and show that Tambara modules give a proarrow equipment for ‐module categories, in which ‐module functors are characterized as 1‐morphisms admitting a right adjoint. Finally, we show that the 2‐category of all ‐module categories embeds into the 2‐category of categories enriched in Tambara modules on , giving an “action via enrichment” result.
Application of Numerical Bifurcation Tracking Strategy to Blade-Tip/Casing Interactions in Aircraft Engines
Authors: Delbé Clément , Colaïtis Yann , Batailly Alain 
Published: April 2024

Abstract
Building on the regularized-Lanczos harmonic balance method (RL-HBM), a previously developed frequency method, this paper presents a numerical bifurcation tracking strategy dedicated to high-dimensional nonlinear mechanical systems. In order to demonstrate its applicability to industrial applications, it is here used to obtain original results in the context of blade-tip/casing interactions in aircraft engines. The emphasis is put specifically on the tracking of predicted limit point (LP) bifurcations as key parameters—such as the amplitude of the aerodynamic forcing applied on the blade, the friction coefficient or the operating clearances—vary. Overall, presented results underline that the employed frequency method is well-suited to tackle the numerical challenges inherent to such computations on high-dimensional systems. For the mechanical system of interest, the industrial fan blade National Aeronautics and Space Administration (NASA) rotor 67, it is shown that the application of the presented strategy yields an efficient way to identify isolated branches of solutions, which may be of critical importance from a design standpoint.
In vitro
activity of gepotidacin and comparator antimicrobials against isolates of nontuberculous mycobacteria (NTM)
Authors: Brown-Elliott Barbara A. , Bush Georgie , Hughes M. Dolores , Rodriguez Eliana , Weikel Chase A. , Min Sharon B. , Wallace Richard J. 
Published: April 2024

ABSTRACT

Novel antimicrobials are needed to treat rising nontuberculous mycobacteria (NTM) infections. Using standard broth microdilution methods, 68 NTM isolates were tested against gepotidacin, a new, first-in-class, oral triazaacenaphthylene bacterial topoisomerase inhibitor. MICs varied (0.25 to >64 µg/mL) with the lowest being
M. fortuitum
complex (0.25–8 µg/mL),
M. mucogenicum
complex (1–2 µg/mL),
M. kansasii
(0.25–8 µg/mL), and
M. marinum
(4–16 µg/mL). Testing greater numbers of some species is suggested to better understand gepotidacin activity against NTM.
Supplemental Material: Long-eccentricity pacing of alluvial stratigraphic architecture in the Eocene Bighorn Basin, Wyoming, USA
Authors: Wang Youwei , Abels Hemmo A , al. et 
Published: April 2024

<p>Figure S1 (UAV-based photogrammetric model in the LIME software) and Figure S2 (comparison of channelized sandstone width and depth in Intervals II and III exhibiting varying dominance of river styles). </p>
Pursuance of a Yoruba name for cervical cancer in Southwest Nigeria: a case study
Authors: Balogun Folusho Mubowale , Omotade Olayemi 
Published: April 2024

ObjectivesParticipants’ comprehension of research process affects the quality of research output, which is the reason why translation of research instruments into local languages is standard practice. Literature has consistently reported that in Africa, knowledge about cervical cancer is low but paradoxically, expressed, and actual uptake of human papillomavirus vaccine for its prevention is high. This study explored the Yoruba names of cervical cancer among Yoruba people in Ibadan, Nigeria to guide the translation of cervical cancer research instruments to Yoruba language.DesignExploratory case study design was used and data were obtained with 10 in-depth interviews and four focused group discussions. Data were analysed using content analysis.SettingsThe study took place in Ibadan North local government area, Southwest Nigeria.ParticipantsThese were 4 traditional healers, 3 Yoruba linguists, 3 public health educators and 38 parents of adolescents.MeasuresThese were Yoruba names for cervical cancer and their meanings.ResultsParticipants were aware of cervical cancer but only the traditional healers and public health educators had names for it. These names were highly varied. The public health educators gave names that were linked with different parts of the female reproductive system and external genital which were actually different medical conditions. Each traditional healer also had different names for cervical cancer, which either described the female body parts, or symptoms of female genital infections. These various names can lead to unnecessary misconceptions and misinformation about cervical cancer, its prevention, management, and research.ConclusionsThere was no consensus Yoruba name for cervical cancer among the study participants. Efforts to educate the Yoruba speaking populace about cervical cancer, its prevention, management and participation in its research can be frustrated if a generally accepted Yoruba name is not provided for this cancer. Stakeholders’ collaboration is required to get an appropriate Yoruba name for cervical cancer.
Association between onychomycosis and ulcerative complications in patients with diabetes: a longitudinal cohort study in Dutch general practice
Authors: Watjer Roeland M , Heckmans Kim ML , Eekhof Just AH , Gummi Luise , Quint Koen D , Numans Mattijs E , Bonten Tobias N 
Published: April 2024

IntroductionDiabetic foot ulcers are feared complications of diabetes mellitus (DM), requiring extensive treatment and hospital admissions, ultimately leading to amputation and increased mortality. Different factors contribute to the development of foot ulcers and related complications. Onychomycosis, being more prevalent in patients with diabetes, could be an important risk factor for developing ulcers and related infections. However, the association between onychomycosis and diabetic complications has not been well studied in primary care.Research design and methodsTo determine the impact of onychomycosis on ulcer development and related complications in patients with diabetes in primary care, a longitudinal cohort study was carried out using routine care data from the Extramural Leiden University Medical Center Academic Network. Survival analyses were performed through Cox proportional hazards models with time-dependent covariates.ResultsData from 48 212 patients with a mean age of 58 at diagnosis of DM, predominantly type 2 (87.8%), were analysed over a median follow-up of 10.3 years. 5.7% of patients developed an ulcer. Onychomycosis significantly increased the risk of ulcer development (HR 1.37, 95% CI 1.13 to 1.66), not affected by antimycotic treatment, nor after adjusting for confounders (HR 1.23, 95% CI 1.01 to 1.49). The same was found for surgical interventions (HR 1.54, 95% CI 1.35 to 1.75) and skin infections (HR 1.48, CI 95% 1.28 to 1.72), again not affected by treatment and significant after adjusting for confounders (HR 1.32, 95% CI 1.16 to 1.51 and HR 1.27, 95% CI 1.10 to 1.48, respectively).ConclusionsOnychomycosis significantly increased the risk of ulcer development in patients with DM in primary care, independently of other risk factors. In addition, onychomycosis increased the risk of surgeries and infectious complications. These results underscore the importance of giving sufficient attention to onychomycosis in primary care and corresponding guidelines. Early identification of onychomycosis during screening and routine care provides a good opportunity for timely recognition of increased ulcer risk.
Photobiomodulation in the treatment of palmar–plantar erythrodysesthesia: a randomised controlled clinical study protocol
Authors: Lestido Valentina , Rodríguez Florencia , Rodríguez Agustín , Pombo Valeria , Barrios Romina , Pavani Christiane 
Published: April 2024

IntroductionHand–foot syndrome, also known as palmar–plantar erythrodysesthesia (PPE), is a complication caused by chemotherapy. Clinically, it manifests as erythema and oedema on the palms of the hands and feet, dry and scaly skin, accompanied by a sensation of tightness and pain. Extreme cases have blisters and ulcerations that may require hospitalisation and/or pause in cancer treatment. It can also be accompanied by paraesthesia. Considering the characteristics, photobiomodulation (PBM) may reduce the PPE effects. The objective of this protocol will be to evaluate the efficacy of PBM in reducing PPE induced by capecitabine and 5-fluorouracil chemotherapy.Methods and analysisThis will be a randomised controlled, double-blind, double-centre clinical trial (Centro Asistencial del Sindicato Médico del Uruguay and Instituto Nacional del Cáncer from Uruguay). The sample population (40 individuals) will be divided into two groups: group 1 will receive moisturising cream plus PBM treatment and group 2 moisturising cream plus PBM sham treatment, at the ratio of 1:1. PBM will be performed at 630 nm two times per week in palmoplantar areas of the hands and feet (4 J/cm2), for 4 weeks. The PPE degree and the data referring to the chemotherapy treatment plan will be measured, prior to the start of treatment in the middle and at the end of it. Quality of life questionnaires will be applied at the beginning of the trial and at the end of treatment. The data will be analysed based on the intention-to-treat analysis and α<0.05 will be considered statistically significant.Ethics and disseminationThe protocol was approved by the Research Ethics Committee of Universidad Católica del Uruguay (220316b), of Centro Asistencial del Sindicato Médico del Uruguay (221989) and of Instituto Nacional del Cáncer (2023-04). The recruitment has already started (March 2023). Protocol version: V.2, 27 October 2023.Trial registration numberClinicalTrials.gov Registry (NCT05337423).
Explore the effect of apparent temperature and air pollutants on the admission rate of acute myocardial infarction in Chongqing, China: a time-series study
Authors: Bai Xiuyuan , Ming Xin , Zhao Mingming , Zhou Li 
Published: April 2024

ObjectiveLimited research has been conducted on the correlation between apparent temperature and acute myocardial infarction (AMI), as well as the potential impact of air pollutants in modifying this relationship. The objective of this study is to investigate the lagged effect of apparent temperature on AMI and assess the effect modification of environmental pollutants on this association.DesignA time-series study.Setting and participantsThe data for this study were obtained from the Academy of Medical Data Science at Chongqing Medical University, covering daily hospitalisations for AMI between 1 January 2015 and 31 December 2016. Meteorological and air pollutant data were provided by China’s National Meteorological Information Centre.Outcome measuresWe used a combined approach of quasi-Poisson generalised linear model and distributed lag non-linear model to thoroughly analyse the relationships. Additionally, we employed a generalised additive model to investigate the interaction between air pollutants and apparent temperature on the effect of AMI.ResultA total of 872 patients admitted to hospital with AMI were studied based on the median apparent temperature (20.43°C) in Chongqing. Low apparent temperature (10th, 7.19℃) has obvious lagged effect on acute myocardial infarction, first appearing on the 8th day (risk ratio (RR) 1.081, 95% CI 1.010 to 1.158) and the greatest risk on the 11th day (RR 1.094, 95% CI 1.037 to 1.153). No lagged effect was observed at high apparent temperature. In subgroup analysis, women and individuals aged 75 and above were at high risk. The interaction analysis indicates that there exist significant interactions between PM2.5 and high apparent temperature, as well as nitrogen dioxide (NO2) and low apparent temperature.ConclusionThe occurrence of decreased apparent temperature levels was discovered to be linked with a heightened relative risk of hospitalisations for AMI. PM2.5and NO2have an effect modification on the association between apparent temperature and admission rate of AMI.
Safety of different concentrations of glycerine enema for meconium evacuation in preterm infants: study protocol for a randomised controlled trial
Authors: Li Xia , Liu Changhong , Zhang Jing , Yu Qingling , Guo Xuemei , Hu Yanling , Shi Jing 
Published: April 2024

IntroductionVarious approaches are employed to expedite the passage of meconium in preterm infants within the neonatal intensive care unit (NICU), with glycerine enemas being the most frequently used. Due to the potential risk of high osmolality-induced harm to the intestinal mucosa, diluted glycerine enema solutions are commonly used in clinical practice. The challenge lies in the current lack of knowledge regarding the safest and most effective concentration of glycerine enema. This research aims to ascertain the safety of different concentrations of glycerine enema solution in preterm infants.Methods and analysisThis study protocol is for a single-centre, two-arm, parallel-group, double-blind and non-inferiority randomised controlled trial. Participants will be recruited from a NICU in a teriary class A hospital in China, and eligible infants will be randomly allocated to either the glycerine (mL): saline (mL) group in a 3:7 ratio or the 1:9 ratio group. The enema procedure will adhere to the standardised operational protocols. Primary outcomes encompass necrotising enterocolitis and rectal bleeding, while secondary outcomes encompass feeding parameters, meconium passage outcomes and splanchnic regional oxygen saturation. Analyses will compare the two trial arms based on an intention-to-treat allocation.Ethics and disseminationThis trial is approved by the ethics committee of the Medical Ethics Committee of West China Second University Hospital of Sichuan University. The results will be published in a peer-reviewed journal.Trial registration numberChiCTR2300079199.
Early adopter insights on physical impact mill technology for harvest weed seed control in Canada
Authors: Tidemann Breanne D. , Geddes Charles M. , Sharpe Shaun M. 
Published: April 2024

The evolution and spread of herbicide resistance among the weed community has increased interest in alternative weed management strategies such as harvest weed seed control. Western Canadian producers have begun adopting physical impact mills as an additional weed management strategy. A survey of early adopters of physical impact mill technology in Canada was conducted to better understand the motivations behind producers adopting, initial experiences, and research needs. Ten producers responded to the survey, accounting for 18 out of an estimated 30 impact mills in use in Canada, believed to be located primarily in the Canadian Prairies. These producers were mainly from larger farms (>4000 ha), equipped the majority of their combines (75% average) and used the mills in essentially all crops grown. The majority of respondents were located in Saskatchewan, with two mills being used in Alberta. Wild oat ( Avena fatua L.) (60%) and kochia ( Bassia scoparia (L.) A.J. Scott) (50%) were the weeds most frequently mentioned as specific motivators of impact mill adoption. Average increased fuel cost from the mill was estimated at CAD$3.46 ha−1, with average annual maintenance costs of about $1500 per impact mill. Producers relied on information from mill companies and other early-adopting farmers primarily, followed by extension talks and social media. Research needs were also identified by producers that could inform the future direction of harvest weed seed control research in Canada. Future research should focus on confirming efficacy, optimizing combine settings, and looking at integrated systems with precision agriculture technologies.
Mathematical modeling of interactions between colon cancer and immune system with a deep learning algorithm
Authors: Raeisi Elham , Yavuz Mehmet , Khosravifarsani Mohammadreza , Fadaei Yasin 
Published: April 2024

AbstractColon cancer is a complex disease with genetically unstable cell lines. In order to better understand the complexity of colon cancer cells and their metastatic mechanisms, we develop a mathematical model in this study. The model is based on a system of fractional-order differential equations and Fractional-Cancer-Informed Neural Networks (FCINN). The model captures a dynamic network of interactions between dendritic cells (DCs), cytotoxic T-cells (CD$$8^+$$8+), helper T-cells (CD$$4^+$$4+), and colon cancer cells through fractional differential equations. By varying the fractional order between 0 and 1, we can classify patients into different groups based on their immune patterns. The goal of this paper is to identify different immune patterns and cancer cell behaviors, as well as the parameters that play an important role in metastasis, control, or elimination of cancer cells in the model. However, several parameters in the model are difficult to estimate in a patient-specific manner. To address this challenge, we use FCINN as an effective deep-learning tool for parameter estimation and numerical simulation of the model. Our findings suggest that the most effective factors in controlling the progression and preventing metastasis of colon cancer are the initial number of cancer cells, the inhibiting rates of tumor cells by DCs, the source of DCs, and the activation of helper T-cells by DCs. These findings suggest that DCs can be used as an immunotherapy tool for the control and treatment of colon cancer.