bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel lβ‐Methylcarbapenems Having Cyclic Sulfonamide Moieties: Synthesis and Evaluation of in‐vitro Biological Activity – Part II
Authors: Kim Seong Jong , Cho Jung‐Hyuck , Oh Chang‐Hyun 
Published: July 2009

AbstractThe synthesis of a new series of 1β‐methylcarbapenems having cyclic sulfonamide moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of a substituent on the pyrrolidine ring was investigated. One particular compound IIIe having a [1,2,5]thiadiazolidin 1,1‐dioxide moiety showed the most potent antibacterial activity.
3‐Imidazolyl‐Substituted Flavans as Potential Antifungal Agents: Synthesis, Stereochemical Properties, and Antifungal Activity
Authors: Emami Saeed , Foroumadi Alireza 
Published: July 2009

AbstractA new series of 3‐imidazolyl‐substituted flavan derivatives being equipped with a N‐(phenethyl)‐azole scaffold as the common pharmacophore of azole antifungals, were synthesized. The stereochemical and conformational properties of compounds were also characterized by 1H‐NMR data. The results of the antifungal evaluation of trans‐3‐imidazolyl‐substituted flavan‐4‐ones and (Z)‐trans‐3‐imidazolyl‐substituted flavan‐4‐one oximes in comparison with the reference drug fluconazole indicated that most target compounds possessed significant in‐vitro antifungal activities against the tested fungi, comparable or superior to fluconazole.
Synthesis of (1R,2R)‐ and (1S,2R)‐1,2‐Epoxy‐3‐hydroxypropylphosphonates as Analogues of Fosfomycin
Authors: Wróblewski Andrzej E. , Szewczyk Eligia M. , Baôk‐Sypień Irena I. 
Published: July 2009

AbstractCyclohexylammonium (1R,2R)‐1,2‐epoxy‐3‐hydroxypropylphosphonate was conveniently synthesized from dibenzyl (1S,2R)‐2,3‐O‐cyclohexylidene‐1,2,3‐trihydroxypropylphosphonate by a reaction sequence including mesylation, hydrolysis of acetal, intramolecular Williamson reaction, and hydrogenation in the presence of cyclohexylamine. For dibenzyl (1S,2R)‐2,3‐O‐cyclohexylidene‐1,2,3‐trihydroxypropylphosphonates the same approach was not successful, since prior the epoxide‐ring closure tritylation of HO–C3 in dibenzyl (1R,2R)‐2,3‐dihydroxy‐1‐mesyloxypropylphosphonate was necessary and the hydrogenolysis of dibenzyl (1S,2R)‐1,2‐epoxy‐3‐trityloxypropylphosphonate yielded a complex reaction mixture.
6‐Substituted Indolo[1,2‐c]quinazolines as New Antimicrobial Agents
Authors: Rohini Rondla , Shanker Kanne , Reddy P. Muralidhar , Sekhar Vasam Chandra , Ravinder Vadde 
Published: July 2009

AbstractA series of 2‐o‐arylidineaminophenylindoles and their cyclic derivatives (indolo[1,2‐c]quinazolines) were synthesized. The reactions occurred under relatively mild conditions and afforded the desired product in good yields. Molecular structures of the synthesized compounds were confirmed by IR, 1H‐NMR, 13C‐NMR, MS spectra, and elemental analyses. Furthermore, all the final products were screened for in‐vitro antibacterial activity against three Gram‐positive and three Gram‐negative bacteria and also tested for their inhibitory action against three strains of fungi. Compound IIc showed potent activity against all the bacterial (except S. typhimurium) and fungal strains. Especially, compounds IIi and IIj which have isoquinolyl and pyridyl substituents displayed potent antibacterial as well as antifungal activities compared to those of the respective standard drugs Ampicillin and Ketoconazole.
Exposure to high static or pulsed magnetic fields does not affect cellular processes in the yeast Saccharomyces cerevisiae
Authors: Anton‐Leberre Veronique , Haanappel Evert , Marsaud Nathalie , Trouilh Lidwine , Benbadis Laurent , Boucherie Helian , Massou Sophie , François Jean M. 
Published: July 2009

AbstractWe report results of a study of the effects of strong static (up to 16 T for 8 h) and pulsed (up to 55 T single‐shot and 4 × 20 T repeated shots) magnetic fields on Saccharomyces cerevisiae cultures in the exponential phase of growth. In contrast to previous reports restricted to only a limited number of cellular parameters, we have examined a wide variety of cellular processes: genome‐scale gene expression, proteome profile, cell viability, morphology, and growth, metabolic and fermentation activity after magnetic field exposure. None of these cellular activities were impaired in response to static or pulsed magnetic field exposure. Our results confirm and extend previous reports on the absence of magnetic field effects on yeast and support the hypothesis that magnetic fields have no impact on the transcriptional machinery and on the integrity of unicellular biological systems. Bioelectromagnetics 31:28–38, 2010. © 2009 Wiley‐Liss, Inc.
Spectroscopic and molecular modeling studies on the binding of the flavonoid luteolin and human serum albumin
Authors: Jurasekova Zuzana , Marconi Giancarlo , Sanchez‐Cortes Santiago , Torreggiani Armida 
Published: July 2009

AbstractLuteolin (LUT) is a polyphenolic compound, found in a variety of fruits, vegetables, and seeds, which has a variety of pharmacological properties. In the present contribution, binding of LUT to human serum albumin (HSA), the most abundant carrier protein in the blood, was investigated with the aim of describing the binding mode and parameters of the interaction. The application of circular dichroism, UV‐Vis absorption, fluorescence, Raman and surface‐enhanced Raman scattering spectroscopy combined with molecular modeling afforded a clear picture of the association mode of LUT to HSA. Specific interactions with protein amino acids were evidenced. LUT was found to be associated in subdomain IIA where an interaction with Trp‐214 is established. Hydrophobic and electrostatic interactions are the major acting forces in the binding of LUT to HSA. The HSA conformations were slightly altered by the drug complexation with reduction of α‐helix and increase of β‐turns structures, suggesting a partial protein unfolding. Also the configuration of at least two disulfide bridges were altered. Furthermore, the study of molecular modeling afforded the binding geometry. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 917–927, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Refinement of the long‐range order parameter in predicting folding rates of two‐state proteins
Authors: Harihar B. , Selvaraj S. 
Published: July 2009

AbstractLong‐range order (LRO) is one of the most successful descriptors in relating the three‐dimensional structures of proteins with their folding rates. LRO highlights the importance of long‐range contacts (residues that are far in sequence and closer in the 3D structure) in determining the folding rates of proteins across all structural classes of proteins. In this work, we have updated the data set of two‐state folding proteins to examine the robustness of LRO parameter and to assess whether any refinements are required in defining the computation of LRO. LRO shows a better correlation (r = −0.85) for the increased dataset with a very small difference in distance cut‐off compared to the old data set and reinforces the robustness of the parameter. When the dataset was grouped into three major structural classes, slight refinement of the parameter (distance of separation in space and sequence) gave better correlations. The corresponding correlation for the three structural classes are r = −0.92; sequence separation 23; spatial distance cut‐off 5.5 Å for all alpha structural class, r = −0.84; sequence separation 43; spatial distance cut‐off 7 Å for all beta structural class and r = −0.82; sequence separation 8; spatial distance cut‐off 8 Å for mixed class proteins. It is envisaged that during the process of protein folding, formation of long‐range contacts beyond the above sequence separation limits may play a key role in determining the folding rates of proteins, and this aspect is discussed in the light of experimental studies on the formation of interresidue contacts and end‐to‐end loops in unfolded polypeptide chains. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 928–935, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Sequence‐dependent folding and unfolding of ligand‐bound purine riboswitches
Authors: Prychyna Oksana , Dahabieh Michael S. , Chao Jay , O'Neill Melanie A. 
Published: July 2009

AbstractRiboswitch regulation of gene expression requires ligand‐mediated RNA folding. From the fluorescence lifetime distribution of bound 2‐aminopurine ligand, we resolve three RNA conformers (Co, Ci, Cc) of the liganded G‐ and A‐sensing riboswitches from Bacillus subtilis. The ligand binding affinities, and sensitivity to Mg2+, together with results from mutagenesis, suggest that Co and Ci are partially unfolded species compromised in key loop‐loop interactions present in the fully folded Cc. These data verify that the ligand‐bound riboswitches may dynamically fold and unfold in solution, and reveal differences in the distribution of folded states between two structurally homologous purine riboswitches: Ligand‐mediated folding of the G‐sensing riboswitch is more effective, less dependent on Mg2+, and less debilitated by mutation, than the A‐sensing riboswitch, which remains more unfolded in its liganded state. We propose that these sequence‐dependent RNA dynamics, which adjust the balance of ligand‐mediated folding and unfolding, enable different degrees of kinetic discrimination in ligand binding, and fine‐tuning of gene regulatory mechanisms. © 2009 Wiley Periodicals, Inc. Biopolymers 91: 953–965, 2009.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Transmural flow bioreactor for vascular tissue engineering
Authors: Bjork Jason W. , Tranquillo Robert T. 
Published: July 2009

AbstractNutrient transport limitation remains a fundamental issue for in vitro culture of engineered tissues. In this study, perfusion bioreactor configurations were investigated to provide uniform delivery of oxygen to media equivalents (MEs) being developed as the basis for tissue‐engineered arteries. Bioreactor configurations were developed to evaluate oxygen delivery associated with complete transmural flow (through the wall of the ME), complete axial flow (through the lumen), and a combination of these flows. In addition, transport models of the different flow configurations were analyzed to determine the most uniform oxygen profile throughout the tissue, incorporating direct measurements of tissue hydraulic conductivity, cellular O2 consumption kinetics, and cell density along with ME physical dimensions. Model results indicate that dissolved oxygen (DO) uniformity is improved when a combination of transmural and axial flow is implemented; however, detrimental effects could occur due to lumenal pressure exceeding the burst pressure or damaging interstitial shear stress imparted by excessive transmural flow rates or decreasing hydraulic conductivity due to ME compaction. The model was verified by comparing predicted with measured outlet DO concentrations. Based on these results, the combination of a controlled transmural flow coupled with axial flow presents an attractive means to increase the transport of nutrients to cells within the cultured tissue to improve growth (increased cell and extracellular matrix concentrations) as well as uniformity. Biotechnol. Bioeng. 2009; 104: 1197–1206. © 2009 Wiley Periodicals, Inc.
Controlled release of neurotrophin‐3 from fibrin‐based tissue engineering scaffolds enhances neural fiber sprouting following subacute spinal cord injury
Authors: Johnson Philip J. , Parker Stanley R. , Sakiyama‐Elbert Shelly E. 
Published: July 2009

AbstractThis study investigated whether delayed treatment of spinal cord injury with controlled release of neurotrophin‐3 (NT‐3) from fibrin scaffolds can stimulate enhanced neural fiber sprouting. Long Evans rats received a T9 dorsal hemisection spinal cord injury. Two weeks later, the injury site was re‐exposed, and either a fibrin scaffold alone, a fibrin scaffold containing a heparin‐based delivery system with different concentrations of NT‐3 (500 and 1,000 ng/mL), or a fibrin scaffold containing 1,000 ng/mL of NT‐3 (no delivery system) was implanted into the injury site. The injured spinal cords were evaluated for morphological differences using markers for neurons, astrocytes, and chondroitin sulfate proteoglycans 2 weeks after treatment. The addition of 500 ng/mL of NT‐3 with the delivery system resulted in an increase in neural fiber density compared to fibrin alone. These results demonstrate that the controlled release of NT‐3 from fibrin scaffolds can enhance neural fiber sprouting even when treatment is delayed 2 weeks following injury. Biotechnol. Bioeng. 2009; 104: 1207–1214. © 2009 Wiley Periodicals, Inc.
Ion‐Pair Binding: Is Binding Both Binding Better?
Authors: Roelens Stefano , Vacca Alberto , Francesconi Oscar , Venturi Chiara 
Published: July 2009

AbstractIt is often tempting to explain chemical phenomena on the basis of intuitive principles, but this practice can frequently lead to biased analysis of data and incorrect conclusions. One such intuitive principle is brought into play in the binding of salts by synthetic receptors. Following the heuristic concept that “binding both is binding better”, it is widely believed that ditopic receptors capable of binding both ionic partners of a salt are more effective than monotopic receptors because of a cooperative effect. Using a newly designed ditopic receptor and a generalized binding descriptor, we show here that, when the problem is correctly formulated and the appropriate algorithm is derived, the cooperativity principle is neither general nor predictable, and that competition between ion binding and ion pairing may even lead to inhibition rather than enhancement of the binding of an ion to a ditopic receptor.
Photoinduced Formation and Characterization of Electron–Hole Pairs in Azaxanthylium‐Derivatized Short Single‐Walled Carbon Nanotubes
Authors: Martín Roberto , Jiménez Liliana B. , Álvaro Mercedes , Scaiano J. C. , García Hermenegildo 
Published: July 2009

Abstract2‐Azaxanthone, a nitrogenated derivative of the well‐studied organic chromophore xanthone, has been covalently bound through 2‐(ethylthio)ethylamido linkers to the carboxylic acid groups of short, soluble single‐walled carbon nanotubes (CNTs) of 450 nm average length, and the resulting azaxanthylium‐functionalized CNTs (AZX‐CNT, 8.5 wt % AZX content) characterized by solution 1H NMR, Raman and IR spectroscopy and thermogravimetric analysis. Comparison of the quenching of the triplet excited state of AZX (steady‐state and time‐resolved) and of the transient optical spectra of CNTs and AZX‐CNT shows that the covalent linkage boosts the interaction between the azaxanthylium moiety and the short CNT units. The triplet excited state of the azaxanthylium derivative is quenched by CNT with and without covalent bonding, but when it is covalently bonded, the singular transient spectrum is compatible with the photogeneration of electron holes through electron transfer from CNT to excited azaxanthylium units.
Systematic Investigation of Molecular Arrangements and Solid‐State Fluorescence Properties on Salts of Anthracene‐2,6‐disulfonic Acid with Aliphatic Primary Amines
Authors: Mizobe Yuji , Hinoue Tomoaki , Yamamoto Atsushi , Hisaki Ichiro , Miyata Mikiji , Hasegawa Yasuchika , Tohnai Norimitsu 
Published: July 2009

AbstractOrganic salts of anthracene‐2,6‐disulfonic acid (ADS) with a wide variety of primary amines have been fabricated, and their arrangements of anthracene molecules and solid‐state fluorescence properties investigated. Single‐crystal X‐ray studies reveal that the salts show seven types of crystal forms and corresponding molecular arrangements of anthracene moieties depending on the amine, while anthracene shows only one form and arrangement in the solid state. Depending on the molecular arrangements, the ADS salts exhibit various solid‐state fluorescence properties: spectral shift (30 nm) and suppression and enhancement of the fluorescence intensity. Especially the ADS salt with n‐heptylamine (nHepA), which shows discrete anthracene moieties in the crystal, exhibits the highest quantum yield (ΦF=46.1±0.2 %) in the series of ADS salts, which exceeds that of anthracene crystal (ΦF=42.9±0.2 %). From these systematic investigations on the arrangements and the solid‐state properties, the following factors are essential for high fluorescence quantum yield in the solid state: prevention of contact between π planes of anthracene moieties and immobilization of anthracene rings. In addition, such organic salts have potential as a system for modulating the molecular arrangements of fluorophores and the concomitant solid‐state properties. Thus, systematic investigation of this system constructs a library of arrangements and properties, and the library leads to remarkable strategies for the development of organic solid materials.
ChemInform Abstract: Crystal Structure of Thallium(I) Trithiocarbonate, Tl2CS3.
Authors: Beck Johannes , Benz Sebastian 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural and Magnetic Properties of Ba0.7Sr0.3Ru1‐xMnxO3 Hexagonal Perovskites.
Authors: Yin Congling , Li Guobao , Lin Jianhua , Attfield J. P. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Experimental Study of the Ternary Ag—Cu—In Phase Diagram
Authors: Bahari Zahra , Elgadi Mohamed , Rivet Jacques , Dugue Jerome 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Green Procedure for the Synthesis of β‐Nitro Sulfides by Michael Addition of Thiols to Nitroolefins.
Authors: Hui Xin‐Pin , Yin Chao , Ma Jun , Xu Peng‐Fei 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heterocycles from Aroylacetic Aldehydes and SH‐Containing Hydrazides.
Authors: Pakal'nis V. V. , Zerova I. V. , Yakimovich S. I. , Ershov A. Yu. , Lagoda I. V. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lewis Acid‐Promoted Electron Transfer Deoxygenation of Epoxides, Sulfoxides, and Amine N‐Oxides: The Role of Low‐Valent Niobium Complexes from NbCl5 and Zn.
Authors: Oh Kyungsoo , Knabe William Eric 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Practical, Two‐Step Synthesis of 2‐Substituted 1,3‐Butadienes.
Authors: Sen Sushmita , Singh Swapnil , Sieburth Scott McN. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Chiral Roche Ester and Its Derivatives via Rh‐Catalyzed Enantioselective Hydrogenation with Chiral Phosphine‐Phosphoramidite Ligands.
Authors: Qiu Min , Wang Dao‐Yong , Hu Xiang‐Ping , Huang Jia‐Di , Yu Sai‐Bo , Deng Jun , Duan Zheng‐Chao , Zheng Zhuo 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rhodium(I)‐Catalyzed Cycloisomerization of 1,3‐Dienes with Alkenes in a Tether.
Authors: Oonishi Yoshihiro , Saito Akira , Mori Miwako , Sato Yoshihiro 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: O‐Aryloxime Ethers from the Copper(II)‐Mediated Cross‐Coupling of Oximes and Phenylboronic Acids.
Authors: Ali Abdelselam , Meyer Adam G. , Tuck Kellie L. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Poly(N,N′‐dichloro‐N‐ethylbenzene‐1,3‐disulfonamide) and N,N,N′,N′‐Tetrachlorobenzene‐1,3‐disulfonamide as Novel Reagents for the Synthesis of N‐Chloroamines, Nitriles and Aldehydes.
Authors: Ghorbani‐Vaghei Ramin , Veisi Hojat 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Propargylamines by a Copper‐Catalyzed Tandem anti‐Markovnikov Hydroamination and Alkyne Addition.
Authors: Zhou Lei , Bohle D. Scott , Jiang Huan‐Feng , Li Chao‐Jun 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Meta‐Selective Copper‐Catalyzed C—H Bond Arylation.
Authors: Phipps Robert J. , Gaunt Matthew J. 
Published: July 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.