bluuebunny/crossref_metadata_2025_split huggingface dataset:
Periungual pyogenic granulomas after ravulizumab therapy in a child with acute myelomonocytic leukemia treated with hematopoietic stem cell transplant
Authors: Iznardo Helena , López‐Torija Ivan , Mateu‐Arrom Laura , Escribano‐Sanz Pablo , Puig Lluís , Roé Esther 
Published: June 2024

AbstractDevelopment of periungual pyogenic granulomas (pPGs) has been associated with several systemic treatments, including retinoids, taxanes, epidermal growth factor receptor inhibitors, and vascular endothelial growth factor inhibitors. We present the case of an 8‐year‐old girl with a personal history of acute myelomonocytic leukemia treated with a haploidentical hematopoietic stem cell transplant who developed pPGs 2 months after starting ravulizumab. Ravulizumab is a monoclonal antibody directed against C5 protein. No previous reports of pPGs development have been described with ravulizumab.
Genome‐wide investigation and analysis of NAC transcription factor family in Populus tomentosa and expression analysis under salt stress
Authors: Han K. , Zhao Y. , Liu J. , Tian Y. , El‐Kassaby Y. A. , Qi Y. , Ke M. , Sun Y. , Li Y. 
Published: June 2024

Abstract

The NAC transcription factor family is one of the largest families of TFs in plants, and members of NAC gene family play important roles in plant growth and stress response. Recent release of the haplotype‐resolved genome assembly of P. tomentosa provide a platform for NAC protein genome‐wide analysis.

A total of 270 NAC genes were identified and a comprehensive overview of the PtoNAC gene family is presented, including gene promoter, structure and conserved motif analyses, chromosome localization and collinearity analysis, protein phylogeny, expression pattern, and interaction analysis.

The results indicate that protein length, molecular weight, and theoretical isoelectric points of the NAC TF family vary, while gene structure and motif are relatively conserved. Chromosome mapping analysis showed that the P. tomentosa NAC genes are unevenly distributed on 19 chromosomes. The interchromosomal evolutionary results indicate 12 pairs of tandem and 280 segmental duplications. Segmental duplication is possibly related to amplification of P. tomentosa NAC gene family. Expression patterns of 35 PtoNAC genes from P. tomentosa subgroup were analysed under high salinity, and seven NAC genes were induced by this treatment. Promoter and protein interaction network analyses showed that PtoNAC genes are closely associated with growth, development, and abiotic and biotic stress, especially salt stress.

These results provide a meaningful reference for follow‐up studies of the functional characteristics of NAC genes in the mechanism of stress response and their potential roles in development of P. tomentosa.
Weaker photosynthetic acclimation to fluctuating than to corresponding steady UVB radiation treatments in grapevines
Authors: Su‐Zhou Chenxing , Durand Maxime , Aphalo Pedro J. , Martinez‐Abaigar Javier , Shapiguzov Alexey , Ishihara Hirofumi , Liu Xu , Robson T. Matthew 
Published: June 2024

AbstractThe effects of transient increases in UVB radiation on plants are not well known; whether cumulative damage dominates or, alternately, an increase in photoprotection and recovery periods ameliorates any negative effects. We investigated photosynthetic capacity and metabolite accumulation of grapevines (Vitis vinifera Cabernet Sauvignon) in response to UVB fluctuations under four treatments: fluctuating UVB (FUV) and steady UVB radiation (SUV) at similar total biologically effective UVB dose (2.12 and 2.23 kJ m−2 day−1), and their two respective no UVB controls. We found a greater decrease in stomatal conductance under SUV than FUV. There was no decrease in maximum yield of photosystem II (Fv/Fm) or its operational efficiency (ɸPSII) under the two UVB treatments, and Fv/Fm was higher under SUV than FUV. Photosynthetic capacity was enhanced under FUV in the light‐limited region of rapid light‐response curves but enhanced by SUV in the light‐saturated region. Flavonol content was similarly increased by both UVB treatments. We conclude that, while both FUV and SUV effectively stimulate acclimation to UVB radiation at realistic doses, FUV confers weaker acclimation than SUV. This implies that recovery periods between transient increases in UVB radiation reduce UVB acclimation, compared to an equivalent dose of UVB provided continuously. Thus, caution is needed in interpreting the findings of experiments using steady UVB radiation treatments to infer effects in natural environments, as the stimulatory effect of steady UVB is greater than that of the equivalent fluctuating UVB.
Reassessing environmental protection in international investment agreements: The case of Vietnam
Authors: Hoang Tien Dat 
Published: June 2024

AbstractThe proliferation of international investment agreements reflects the tireless efforts of many governments in the world to attract foreign investment and significantly improve their investment environment, including Vietnam. However, investment overshielding without regard to public policy objectives also has negative consequences, such as indirectly and directly causing environmental pollution at investment sites. Vedan Vietnam and Formosa Ha Tinh Steel are prime examples of ecological incidents with long‐term damage to the host State. Using critical and case study approaches, this article examines the reasons behind those incidents and analyses Vietnam's improper response to the cases. More importantly, the article criticises the lack of alignment of the domestic legal system and international investment law. Finally, the article suggests the interconnected relationship between domestic and international law and recommends treaty‐making directions to avoid the risk of Vietnam and other ASEAN countries becoming a ‘new haven’ of environmental pollution.
Treatable traits and exacerbation risk in patients with uncontrolled asthma prescribed GINA step 1–3 treatment: A nationwide asthma cohort study
Authors: Konradsen Jon R. , Selberg Stina , Ödling Maria , Sundbaum Johanna Karlsson , Bossios Apostolos , Stridsman Caroline 
Published: June 2024

AbstractBackground and ObjectiveUncontrolled asthma in patients treated for mild/moderate disease could be caused by non‐pulmonary treatable traits (TTs) that affect asthma control negatively. We aimed to identify demographic characteristics, behavioural (smoking) and extrapulmonary (obesity, comorbidities) TTs and the risk for future exacerbations among patients with uncontrolled asthma prescribed step 1–3 treatment according to the Global Initiative for Asthma (GINA).MethodsTwenty‐eight thousand five hundred eighty‐four asthma patients (≥18 y) with a registration in the Swedish National Airway Register between 2017 and 2019 were included (index‐date). The database was linked to other national registers to obtain information on prescribed drugs 2‐years pre‐index and exacerbations 1‐year post‐index. Asthma treatment was classified into step 1–3 or 4–5, and uncontrolled asthma was defined based on symptom control, exacerbations and lung function.ResultsGINA step 1–3 included 17,318 patients, of which 9586 (55%) were uncontrolled (UCA 1–3). In adjusted analyses, UCA 1–3 was associated with female sex (OR 1.34, 95% CI 1.27–1.41), older age (1.00, 1.00–1.00), primary education (1.30, 1.20–1.40) and secondary education (1.19, 1.12–1.26), and TTs such as smoking (1.25, 1.15–1.36), obesity (1.23, 1.15–1.32), cardiovascular disease (1.12, 1.06–1.20) and depression/anxiety (1.13, 1.06–1.21). Furthermore, UCA 1–3 was associated with future exacerbations; oral corticosteroids (1.90, 1.74–2.09) and asthma hospitalization (2.55, 2.17–3.00), respectively, also when adjusted for treatment step 4–5.ConclusionOver 50% of patients treated for mild/moderate asthma had an uncontrolled disease. Assessing and managing of TTs such as smoking, obesity and comorbidities should be conducted in a holistic manner, as these patients have an increased risk for future exacerbations.
How good are large language models at product risk assessment?
Authors: Collier Zachary A. , Gruss Richard J. , Abrahams Alan S. 
Published: June 2024

AbstractProduct safety professionals must assess the risks to consumers associated with the foreseeable uses and misuses of products. In this study, we investigate the utility of generative artificial intelligence (AI), specifically large language models (LLMs) such as ChatGPT, across a number of tasks involved in the product risk assessment process. For a set of six consumer products, prompts were developed related to failure mode identification, the construction and population of a failure mode and effects analysis (FMEA) table, risk mitigation identification, and guidance to product designers, users, and regulators. These prompts were input into ChatGPT and the outputs were recorded. A survey was administered to product safety professionals to ascertain the quality of the outputs. We found that ChatGPT generally performed better at divergent thinking tasks such as brainstorming potential failure modes and risk mitigations. However, there were errors and inconsistencies in some of the results, and the guidance provided was perceived as overly generic, occasionally outlandish, and not reflective of the depth of knowledge held by a subject matter expert. When tested against a sample of other LLMs, similar patterns in strengths and weaknesses were demonstrated. Despite these challenges, a role for LLMs may still exist in product risk assessment to assist in ideation, while experts may shift their focus to critical review of AI‐generated content.
Freshwater microbial mud: Punctuated diagenesis during marine transgression in the Florida Everglades, USA
Authors: Pederson Chelsea L. , Klaus James S. , McNeill Donald F. , Swart Peter K. 
Published: June 2024

AbstractThis manuscript documents the diagenetic progression from deposition to early burial of freshwater low‐Mg calcite mud within a Holocene sequence of the Everglades and Florida Bay (Florida, USA). During initial, in situ burial, the texturally‐complex, organic‐rich mud, exhibits high susceptibility to alteration, within a primarily dissolution‐driven realm. Seaward, a brackish‐water transitional burial environment currently displays evidence of mixed precipitation and dissolution. This brackish stage burial alteration may be due to fluid exchange (a relatively high fluid‐to‐rock ratio) in a submerged estuary setting. Lastly, the burial environment in Florida Bay records a transgression from freshwater to near‐normal marine conditions. This island setting currently exhibits a diagenetic trend towards low‐Mg calcite precipitation in intervals of both the marine and freshwater mud. Burial of freshwater mud beneath nearly 3 m of marine mud during rising sea level appears to have preserved a considerable amount of original textures, as compared with younger freshwater deposits now within the transitional brackish‐water setting. Geochemical and textural data within the freshwater mud sections suggest that complex early diagenesis begins shortly after burial at the site of formation, and perhaps even during deposition. The findings herein document three major implications for coastal zone paludal carbonates: (i) that incipient textural diagenesis in low‐Mg calcite crystals can be extremely early and the stability and petrographic fidelity of these deposits are vulnerable due to the open, trellis‐like structure of the crystals; (ii) relatedly, the stable isotope signature of the original low‐Mg calcite crystals is also vulnerable to alteration by secondary precipitation within the open crystal structure; and (iii) during marine transgression, the paludal calcite crystals likely experience a shift from interstitial fluids that are dissolution‐dominated (freshwater) to more precipitation‐dominated as marine fluids overtake the pore fluid regime. Because palustrine deposits are used as palaeoenvironmental archives, it is important to understand their diagenetic and preservation potential. This study has implications for those concerned with the deposition, reactivity and preservation potential of continental and microbial carbonates.
Associations among intimate partner violence, suicidal ideation, suicide behaviors, non‐suicidal self‐injury, and psychological well‐being in Black American emerging adults
Authors: McCollum Diamonde C. , Smathers Steven E. , Sullivan Tara , Jowaheer Yajna , Mereish Ethan H. 
Published: June 2024

AbstractBackgroundSuicidal ideation and behavior and non‐suicidal self‐injury (NSSI) among Black emerging adults is a major public health concern. Intimate partner violence (IPV) is a significant risk factor for suicidal ideation and behavior and NSSI, but there is little work examining the buffering effect of psychological well‐being (PWB). The purpose of this study was to examine the associations between IPV, suicide ideation and behavior, and NSSI, and the moderating role of PWB on these associations.MethodSecondary data analyses were conducted using a subsample of Black American emerging adults (N = 4694) from the National College Health Assessment.ResultsIPV was associated with greater odds of suicide ideation, past‐year suicide attempt, and NSSI. PWB was associated with lower odds of suicide ideation, past‐year suicide attempt, and NSSI. PWB did not moderate the relationships between IPV and the outcomes.ConclusionsIPV was a risk factor for suicidal ideation, suicide attempt, and NSSI among Black American emerging adults. PWB was associated with lower suicidal ideation and behavior and NSSI engagement, suggesting it can be a protective factor. Bolstering PWB in Black communities may be beneficial in intervention and prevention efforts.
The American Association of Tissue Banks tissue donor screening for Mycobacterium tuberculosis—Recommended criteria and literature review
Authors: Greenwald Melissa A. , Edwards Noelle , Eastlund D. Ted , Gurevich Inga , Ho Andrea Pervine‐Zaman , Khalife Ghada , Lin‐Torre Janet , Thompson Hannis W. , Wilkins Ross M , Alrabaa Sally F. 
Published: June 2024

AbstractAfter two multistate outbreaks of allograft tissue‐transmitted tuberculosis (TB) due to viable bone, evidence‐based donor screening criteria were developed to decrease the risk of transmission to recipients. Exclusionary criteria, commentary, and references supporting the criteria are provided, based on literature search and expert opinion. Both exposure and reactivation risk factors were considered, either for absolute exclusion or for exclusion in combination with multiple risk factors. A criteria subset was devised for tissues containing viable cells. Risk factors for consideration included exposure (e.g., geographic birth and residence, travel, homelessness, incarceration, healthcare, and workplace) and reactivation (e.g., kidney disease, liver disease, history of transplantation, immunosuppressive medications, and age). Additional donor considerations include the possibility of sepsis and chronic illness. Donor screening criteria represent minimal criteria for exclusion and do not completely exclude all possible donor TB risks. Additional measures to reduce transmission risk, such as donor and product testing, are discussed but not included in the recommendations. Careful donor evaluation is critical to tissue safety.
Hospitalizations for opportunistic infections following transplantation and associated risk factors: A national cohort study of Medicare beneficiaries
Authors: Mezochow Alyssa K. , Schaubel Douglas E. , Peyster Eliot G. , Lewis James D. , Goldberg David S. , Bittermann Therese 
Published: June 2024

AbstractBackgroundOpportunistic infections (OIs) are a significant cause of morbidity and mortality after organ transplantation, though data in the liver transplant (LT) population are limited.MethodsWe performed a retrospective cohort study of LT recipients between January 1, 2007 and Deceber 31, 2016 using Medicare claims data linked to the Organ Procurement and Transplantation Network database. Multivariable Cox regression models evaluated factors independently associated with hospitalizations for early (≤1 year post transplant) and late (>1 year) OIs, with a particular focus on immunosuppression.ResultsThere were 11 320 LT recipients included in the study, of which 13.2% had at least one OI hospitalization during follow‐up. Of the 2638 OI hospitalizations, 61.9% were early post‐LT. Cytomegalovirus was the most common OI (45.4% overall), although relative frequency decreased after the first year (25.3%). Neither induction or maintenance immunosuppression were associated with early OI hospitalization (all p > .05). The highest risk of early OI was seen with primary sclerosing cholangitis (aHR 1.74; p = .003 overall). Steroid‐based and mechanistic target of rapamycin inhibitor‐based immunosuppression at 1 year post LT were independently associated with increased late OI (p < .001 overall).ConclusionThis study found OI hospitalizations to be relatively common among LT recipients and frequently occur later than previously reported. Immunosuppression regimen may be an important modifiable risk factor for late OIs.
Whole‐genome sequencing of a worldwide collection of sugarcane cultivars (Saccharum spp.) reveals the genetic basis of cultivar improvement
Authors: Li Xuhui , Chen Xinglong , Fang Junteng , Feng Xiaomin , Zhang Xiangbo , Lin Huanzhang , Chen Weiwei , Zhang Nannan , He Huiyi , Huang Zhenghui , Xue Xiaoming , Li Yucong , Fan Lina , Lai Ruiqiang , Huo Zhenye , Cui Mingyang , Deng Guangyan , Zaid Chachar , Su Yueping , Zhang Jisen , Cai Weijun , Qi Yongwen 
Published: June 2024

SUMMARYSugarcane is the main source of sugar worldwide, and 80% of the sucrose production comes from sugarcane. However, the genetic differentiation and basis of agronomic traits remain obscure. Here, we sequenced the whole‐genome of 219 elite worldwide sugarcane cultivar accessions. A total of approximately 6 million high‐quality genome‐wide single nucleotide polymorphisms (SNPs) were detected. A genome‐wide association study identified a total of 2198 SNPs that were significantly associated with sucrose content, stalk number, plant height, stalk diameter, cane yield, and sugar yield. We observed homozygous tendency of favor alleles of these loci, and over 80% of cultivar accessions carried the favor alleles of the SNPs or haplotypes associated with sucrose content. Gene introgression analysis showed that the number of chromosome segments from Saccharum spontaneum decreased with the breeding time of cultivars, while those from S. officinarum increased in recent cultivars. A series of selection signatures were identified in sugarcane improvement procession, of which 104 were simultaneously associated with agronomic traits and 45 of them were mainly associated with sucrose content. We further proposed that as per sugarcane transgenic experiments, ShN/AINV3.1 plays a positive role in increasing stalk number, plant height, and stalk diameter. These findings provide comprehensive resources for understanding the genetic basis of agronomic traits and will be beneficial to germplasm innovation, screening molecular markers, and future sugarcane cultivar improvement.
Strigolactone induces D14‐dependent large‐scale changes in gene expression requiring SWI/SNF chromatin remodellers
Authors: Humphreys Jazmine L. , Beveridge Christine A. , Tanurdžić Miloš 
Published: June 2024

SUMMARYStrigolactones (SL) function as plant hormones in control of multiple aspects of plant development, mostly via the regulation of gene expression. Immediate early‐gene regulation by SL remains unexplored due to difficulty in dissecting early from late gene expression responses to SL. We used synthetic SL, rac‐GR24 treatment of protoplasts and RNA‐seq to explore early SL‐induced changes in gene expression over time (5–180 minutes) and discovered rapid, dynamic and SL receptor D14‐dependent regulation of gene expression in response to rac‐GR24. Importantly, we discovered a significant dependence of SL signalling on chromatin remodelling processes, as the induction of a key SL‐induced transcription factor BRANCHED1 requires the SWI/SNF chromatin remodelling ATPase SPLAYED (SYD) and leads to upregulation of a homologue SWI/SNF ATPase BRAHMA. ATAC‐seq profiling of genome‐wide changes in chromatin accessibility in response to rac‐GR24 identified large‐scale changes, with over 1400 differentially accessible regions. These changes in chromatin accessibility often precede transcriptional changes and are likely to harbour SL cis‐regulatory elements. Importantly, we discovered that this early and extensive modification of the chromatin landscape also requires SYD. This study, therefore, provides evidence that SL signalling requires regulation of chromatin accessibility, and it identifies genomic locations harbouring likely SL cis‐regulatory sequences.
Dancing with foxes: More‐than‐human design in ‘the chicken city’
Authors: Oliver Catherine 
Published: June 2024

AbstractUrban chicken‐keeping is on the rise in London, in private gardens, community gardens, allotments, schools, and urban farm projects. In welcoming chickens into the city, urban spaces are being transformed: coops are being built, runs constructed, chicken‐friendly flora introduced, and space landscaped to accommodate both chickens and humans. Underneath the design of these multispecies urban spaces, there is a desire to bring the good life into the city, through a return to nature. Chicken‐keeping is being lauded by urban keepers and commentators alike as a response to urban crises over food provenance and quality, environmental ethics, and a growing unease with industrial agriculture. However, after chickens arrive in these urban spaces, it becomes quickly apparent that the design of the urban barnyard imposed by the human is rarely practical for, or enjoyed by, chickens: perfectly laid lawns are torn up, plants are demolished, and vegetable patches are gorged on, and chickens are at the mercy of local foxes. When chickens enter these urban barnyards, they demand humans pay attention to their desires, behaviours, and territoriality by overflowing and expanding their assigned space. As such, designing the urban barnyard is an ongoing spatio‐temporal iterative process between chickens, humans, and other non‐human actors in the more‐than‐human city. In this paper, using the case of the urban chicken, I argue that more‐than‐human (urban) geographies can find generative collaborations with design thinking in theorising human–environmental relationalities.
Broadening the scope of weed research: Integrating ecological theories to propel weed management
Authors: Blank Lior , Mesgaran Mohsen B. 
Published: June 2024

AbstractWeed science plays a vital role in mitigating the negative impacts of weeds in agriculture and natural ecosystems. However, the field has received criticism for its limited theoretical foundation and excessive focus on phenomenological and narrow scope. Our contention is that weed science needs to integrate more ecological theories to foster a deeper understanding of weed ecology, biology, and management. By embracing theoretical frameworks, weed science can enhance its ability to predict and explain weed dynamics, identify underlying mechanisms, and develop sustainable management strategies. This insight emphasizes the advantages of integrating theoretical approaches and offers practical recommendations to integrate ecological theory effectively into weed science research.