bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penifuranone A: A Novel Alkaloid from the Mangrove Endophytic Fungus Penicillium crustosum SCNU-F0006
Authors: Jia Hao , Wu Li , Liu Rongrong , Li Jialin , Liu Lingling , Chen Chen , Li Junsen , Zhang Kai , Liao Junjiang , Long Yuhua 
Published: May 2024

One previously undescribed alkaloid, named penifuranone A (1), and three known compounds (2–4) were isolated from the mangrove endophytic fungus Penicillium crustosum SCNU-F0006. The structure of the new alkaloid (1) was elucidated based on extensive spectroscopic data analysis and single-crystal X-ray diffraction analysis. Four natural isolates and one new synthetic derivative of penifuranone A, compound 1a, were screened for their antimicrobial, antioxidant, and anti-inflammatory activities. Bioassays revealed that penifuranone A (1) exhibited strong anti-inflammatory activity in vitro by inhibiting nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 cells with an IC50 value of 42.2 μM. The docking study revealed that compound 1 exhibited an ideal fit within the active site of the murine inducible nitric oxide synthase (iNOS), establishing characteristic hydrogen bonds.
Probing Relativistic Heavy-Ion Collisions via Photon Anisotropic Flow Ratios. A Brief Review
Authors: Chatterjee Rupa , Dasgupta Pingal 
Published: May 2024

The anisotropic flow of photons produced in relativistic nuclear collisions is known as a promising observable for studying the initial state and the subsequent evolution of the hot and dense medium formed in such collisions. The investigation of photon anisotropic flow coefficients, vn, has attracted high interest over the last decade, involving both theory and experiment. The thermal emission of photons and their anisotropic flow are found to be highly sensitive to the initial state of the fireball, where even slight modifications can lead to significant variations in the final state results. In contrast, the ratio of photon anisotropic flow stands out as a robust observable, exhibiting minimal sensitivity to the initial conditions. Here, we briefly review the studies of the individual elliptic and triangular flow parameters of photons as well as their ratios and how these parameters serve as valuable probes for investigating the intricacies of the initial state and addressing the challenges posed by the direct photon puzzle.
Oral pathology following treatment of brain tumors in childhood
Authors: Obukhov Yu. A. , Zhukovskaya E. V. , Borodina I. D. , Charchikov D. V. , Alekseeva S. I. , Karelin А. F. 
Published: May 2024

Relevance. The limited selectivity of antitumor therapy for central nervous system neoplasms entails the risk of dental morbidity in patients.The aim of the study is to assess the severity of damage to the dental hard tissues in patients with tumors of the posterior cranial fossa (medulloblastoma, astrocytoma) and other tumors of the central nervous system.Materials and methods. Three comparison groups were established based on the toxicity profiles of antitumor therapy among 251 patients at the "Russian Field" treatment and rehabilitation scientific center, to assess the characteristics of oral health status. The assessment of oral health status included diagnosing the carious process and calculating the DMFT index. The degree of damage to the dental hard tissues was evaluated on a four-point scale. The clinical manifestations of oral cavity pathology were compared using the Z-criterion for multiple pairwise comparisons of data, with adjustments for multiple testing (Multiple pairwise comparison Z-test for proportions with multiple testing correction) using the free R software version 3.5.2. The null hypothesis of equal indicators in the compared groups was rejected with a 95% confidence probability when comparing groups of patients.Results. Dental hard tissue pathology was significantly more prevalent in patients with medulloblastoma compared to those diagnosed with astrocytomas and other central nervous system tumors. Additionally, the prevalence of dental hard tissue pathology progressively decreased as the observation period following the completion of antitumor remission was extended.Conclusion. The most severe damage to dental hard tissues is observed in patients with medulloblastoma, who undergo more intensive antitumor therapy compared to those with CNS tumors of other histological types.
‘ThinkCancer!’: randomised feasibility trial of a novel practice-based early cancer diagnosis intervention
Authors: Disbeschl Stefanie LJ , Hendry Annie K , Surgey Alun , Walker Daniel , Goulden Nia , Anthony Bethany F , Neal Richard , Williams Nefyn H , Hoare Zoë Susannah Jane , Hiscock Julia , Edwards Rhiannon Tudor (RT) , Lewis Ruth , Wilkinson Clare 
Published: May 2024

Background
UK cancer deaths remain high; primary care is key for earlier cancer diagnosis as half of avoidable delays occur here. Improvement is possible through lower referral thresholds, better guideline adherence, and better safety-netting systems. Few interventions target whole practice teams. We developed a novel whole-practice team intervention to address this.

Aim
To test the feasibility and acceptability of a novel, complex behavioural intervention, ‘ThinkCancer!’, for assessment in a subsequent Phase III trial.

Design & setting
Pragmatic, superiority pilot randomised controlled trial (RCT) with an embedded process evaluation and feasibility economic analysis in Welsh general practices.

Method
Clinical outcome data were collected from practices (the unit of randomisation). Practice characteristics and cancer safety-netting systems were assessed. Individual practice staff completed evaluation and feedback forms and qualitative interviews. The intervention was adapted and refined.

Results
Trial recruitment and workshop deliveries took place between March 2020 and May 2021. Trial progression criteria for recruitment, intervention fidelity, and routine data collection were met. Staff-level fidelity, retention, and individual level data collection processes were reviewed and amended. Interviews highlighted positive participant views on all aspects of the intervention. All practices set out to liberalise referral thresholds appropriately, implement guidelines, and address safety-netting plans in detail.

Conclusion
‘ThinkCancer!’ appears feasible and acceptable. The new iteration of the workshops was completed and the Phase III trial has been funded to assess the effectiveness and cost-effectiveness of this novel professional behaviour change intervention. Delivery at scale to multiple practices will likely improve fidelity and reach.
Penerapan Fuzzy Tsukamoto untuk Sistem Prediksi Jumlah Produksi Roti Berbasis Web
Authors: Nurhayati Sri , Irmayanti Hani , Wijaya Yusuf Rakha 
Published: May 2024

This research aims to create a system that will provide information about predicting the amount of production to help related parties in determining the amount of production, in addition to seeing the accuracy of the use of methods in predicting the amount of production. Production activities are a series of activities carried out to turn raw materials into products that can be marketed and sold. One of the things involved in this process is the amount of raw materials that will be made into finished products. A calculation process is needed to predict the number of products to be produced to minimize production costs. The method used for the prediction process is the Fuzzy Tsukamoto method, where this method overcomes uncertainty and complexity in decision making. Calculation of errors in predicting is used mean absolute percentage error (MAPE), and for system design an object approach is used using Unified Modeling Language (UML) tools. The results of the study state that system testing is worth 92%, meaning that the system can be used as needed, and for the method used to get an error value of 10.62% so that the Fuzzy Tsukamoto method can be used to predict the amount of production.
Plant-Derived Exosomes as Novel Nanotherapeutics Contrive Glycolysis Reprogramming-Mediated Angiogenesis for Diabetic Ulcer Healing
Authors: Tan Minhong , Liu Yuda , Xu Yang , Yan Ge , Zhou Nan , Chen Haoran , Jiang Zhihong , Peng Lihua 
Published: May 2024

Reversal of endothelial cell (EC) dysfunction under high-glucose (HG) conditions to achieve angiogenesis has remained a big challenge in diabetic ulcers. Herein, exosomes derived from medicinal plant ginseng (GExos) were shown as excellent nanotherapeutics with biomimetic cell membrane-like structures to be able to efficiently transfer the encapsulated active substances to ECs, resulting in a marked reprogramming of glycolysis by up-regulating anaerobic glycolysis and down-regulating oxidative stress, which further restore the proliferation, migration, and tubule formation abilities of ECs under HG conditions. In vivo, GExos enhance the angiogenesis and nascent vessel network reconstruction in full-thickness diabetic complicated skin ulcer wounds in mice with high biosafety. GExos were shown as promising nanotherapeutics in stimulating glycolysis reprogramming-mediated angiogenesis in diabetic ulcers, possessing wide application potential for reversing hyperglycemic dysangiogenesis and stimulating vascular regeneration.
Algunos aportes del pensamiento situado para pensar procesos sociales
Authors: Díaz Rojo María Florencia 
Published: May 2024

Este artículo intenta recuperar los postulados del Pensamiento Situado, sistematizando lecturas de diferentes autores pero sobre todo de la mano del Dr. Alejandro Auat. Este brinda un compilado muy amplio de diversas corrientes teóricas que permiten comprender la idea de situacionalidad, a las cuales denomina como constelación conceptual. Entendiendo que la idea de situacionalidad va más allá de la clara referencia a las circunstancias que imprimen una particularidad determinada a cada pensamiento, es decir a un pensamiento producido en un contexto determinado, sino que se trata de sumarle a ello una mirada crítica, gnoseológica y axiológica del punto de vista desde donde se habla y se piensa. Esto a su vez implica un posicionamiento político, es decir una toma de posición y va a contramano del pensamiento dominante en las ciencias sociales.
Luego de revisar las bases de este pensamiento se intentará hacer una breve síntesis de algunos aportes que brinda este a los y las investigadores para pensar diferentes procesos sociales dentro del campo de las ciencias sociales. Por lo tanto, cabe señalar que este no será un análisis exhaustivo que recupere todos los aportes posibles, sino los que se consideran centrales.
Intravenous Insulin Infusion Rate and Its Impact on the Time to Resolution of Diabetic Ketoacidosis
Authors: Bykov Y. V. , Obedin A. N. , Muravyova A. A. , Zinchenko O. V. 
Published: May 2024

Background: Diabetic ketoacidosis (DKA) is an acute and severe complication of type 1 diabetes that is highly prevalent in children and adolescents. Intravenous (IV) insulin infusion is the mainstay of DKA treatment in the intensive care unit; however, standard-dose (0.1 U/kg/h) insulin infusion increases the risk of cerebral edema.Objective: To compare the efficacy and safety of low-dose (0.05 U/kg/h) vs high-dose (0.1 U/kg/h) IV insulin infusion in children and adolescents treated for DKA. Materials and methods: Our randomized single-blind study included 86 patients aged 5 to 14 years urgently hospitalized with symptoms of DKA. Group 1 comprised 40 children who received IV insulin at the low rate (0.05 U/kg/h), whereas group 2 included 46 children who received IV insulin at the standard rate (0.1 U/kg/h). During the treatment we compared the time to DKA resolution and blood glucose level decrease to 15 mmol/L and recorded cases of hypoglycemia, hypokalemia, and papilledema. The MannWhitney test was used to determine whether differences were statistically significant.Results: There was no difference between groups 1 and 2 in DKA treatment duration. The blood glucose level was found to decline to 15 mmol/L more slowly in children who received IV insulin at 0.05 U/kg/h. Hypoglycemia, hypokalemia, and papilledema were more common in the standard-dose (0.1 U/kg/h) group.Conclusions: The low-dose IV insulin infusion (0.05 U/kg/h) is safer in terms of complications (cerebral edema) associated with pediatric DKA treatment in the intensive care unit and not inferior to the standard recommended dose (0.1 U/kg/h) in efficacy.
Possibilities of a New Technique for Determining Residual Urine in Women After Synthetic Sling Surgery
Authors: Danilov V. V. , Volnykh I. Yu. , Danilov V. V. , Danilov V. V. 
Published: May 2024

Background: Synthetic sling surgery has become quite a popular method for stress urinary incontinence treatment over the past quarter century. The effectiveness of eliminating urinary incontinence is estimated by various authors from 70% to 95%; however, urinary disorders often develop after surgery. In some cases, conditions underlying incomplete bladder emptying occur. In addition, clinical symptoms of imperative urination disorders appear. They are generally known as de novo and manifest with urinary frequency, imperative urges, and urge incontinence. Literature shows that obstructed urination in women is also common, and synthetic sling surgery is indicated.Objective: To assess the incidence of obstructed urination and development of incomplete bladder emptying in female patients with synthetic tapes placed under the urethra.Material and methods: We observed a group of female patients examined at the Center for “Urination Pathology” (Vladivostok, Russian Federation) for stress urinary incontinence. The mean age in the group (40 cases) was 53.4±4.2 years (range, 35-68 years). All the patients underwent trocar synthetic sling surgery. Home uroflowmetry was performed before surgery and within 3 months after discharge.Results: After synthetic sling surgery, the urination obstruction and probability of residual urine formation were found to increase. At the same time, there was a weak association between preoperative obstruction and difficulty after synthetic tape placement. We measured incomplete bladder emptying using a new technique: by original Russian UFM “SIGMA” uroflowmeter.Conclusions: The study data support the need for widespread use of a new technique of noninvasive urodynamics for residual urine determination. The use of a 2-sensor uroflowmeter with an original algorithm for processing urine flow records is a fundamentally new tool for assessing the functional state of the lower urinary tract that can detect residual urine with a probability of 0.95 and help solve a rather complex clinical problem.
Speckle-Tracking Echocardiography in Assessment of Breast Cancer Therapy-Related Subclinical Cardiac Dysfunction
Authors: Akbalaeva B. A. , Shulzhenko L. V. , Pershukov I. V. , Raiimbek uulu N. , Batyraliev T. A. , Gurovich O. V. , Vinogradskaia V. V. , Jainakbayev N. T. , Seidalin A. O. , Kamaliyeva M. R. 
Published: May 2024

Background: Cancer therapy-related cardiac dysfunction (CTRCD) is a new term that encompasses a wide range of potential manifestations and is etiologically associated with a wide variety of cancer treatments. Detection of early subclinical cardiac dysfunction is of great clinical importance.Objective: To assess subclinical CTRCD in women with HER2-positive locally advanced or metastatic breast cancer undergoing a course of anthracyclines (doxorubicin), docetaxel, and trastuzumab. We prospectively enrolled women aged 18-75 years with an established diagnosis of HER2-positive locally advanced or metastatic breast cancer across 3 centers.Material and methods: We monitored 122 women with HER2-positive locally advanced or metastatic breast cancer undergoing a course of anthracyclines (doxorubicin), docetaxel, and trastuzumab using speckle-tracking echocardiography. Based on the treatment protocol, we formed 3 comparison blocks: block 1 (chemotherapy: doxorubicin+cyclophosphamide); block 2 (chemotherapy+targeted therapy: docetaxel+trastuzumab), and block 3 (targeted therapy: trastuzumab).Results: The rate of subclinical CTRCD detection was high and exceeded 20%-30% in all comparison blocks after the 3rd course of chemotherapy, chemotherapy+targeted therapy, and targeted therapy. The rate of subclinical CTRCD increased significantly from the 1st to the 2nd, from the 2nd to the 3rd, from the 3rd to the 4th therapy courses in each block. Comparisons between the blocks were significant only after the 4th course of chemotherapy and the 4th course of targeted therapy (Yates-corrected chi-square, P=.0394); all the other comparisons between the blocks were not significant in terms of subclinical CTRCD rate.Discussion: Given the growing number of patients with breast cancer, such frequent monitoring of the cardiac function is likely to improve the quality of cancer treatment and might have a positive impact on the overall survival of patients with breast cancer. Conclusions: Criteria for frequency of echocardiographic monitoring of cardiac dysfunction in patients with malignant tumors, especially with HER2-positive breast cancer, should be revised.
Supraciliary Approach in Surgical Treatment of Zygomaticomaxillary Complex Fractures
Authors: Kokayev K. T. , Teremov A. V. , Zabunyan G. A. , Martirosyan A. A. , Baryshev A. G. , Porhanov V. A. 
Published: May 2024

Objective: To demonstrate the effectiveness of a supraciliary approach in zygomaticomaxillary complex fractures treatment.Case report: Patient A. (33-year-old man) was admitted to the Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1 (Krasnodar, Russian Federation) with a diagnosis of traumatic fractures of the right and left zygomaticomaxillary complexes. According to the medical history, the injury was caused by a car accident. The patient underwent computed tomography of the facial skeleton. Computed tomography findings: fractures of lateral and medial orbital walls, supraorbital and infraorbital rims, glabella, and nasal septum. The patient underwent repositioning of the bone fragments and internal fixation with metal implants. The glabella fracture was reduced through a supraciliary approach. The function of the mimic muscles was fully preserved. The configuration of the face and soft tissues was restored. No soft tissue edema was observed. The postoperative scar is visualized after the unfolding of the orbito-palpebral fold of the upper eyelid.Conclusions: The systematic use of esthetic approaches by surgeons completely changes the rooted traditional way of managing patients with various maxillofacial pathologies. In addition to outstanding esthetic results, it increases the surgeons’ expertise level and the range of tasks a comprehensively developed specialist is capable of dealing with. One of the most crucial aspects is improvement of patients’ quality of life.
أساليب الحياة وعلاقتها بأعراض اضطراب الشخصية الهستيرية لدى طلبة جامعة اليرموك
Authors: Alshamali Zainab Aref Ali , Alshagran Hanan Ibraheem Abdalrahman 
Published: May 2024

الأهداف: هدفت الدراسة التعرف إلى أساليب الحياة وعلاقتها بأعراض اضطراب الشخصية الهستيرية.
المنهجية: استخدم المنهج الوصفي الارتباطي ، وقد تم تطوير مقياسي: أساليب الحياة، وأعراض اضطراب الشخصية الهستيرية طبق على عينة الدراسة من (717) طالبًا وطالبة، والذين اختيروا بالطريقة المتيسرة.
النتائج : أظهرت نتائج الدراسة أن أسلوب الحياة السائد لدى طلبة جامعة اليرموك (المفيد اجتماعيًا)، وأن درجة توافر أعراض اضطراب الشخصية الهستيرية لدى طلبة جامعة اليرموك متوسطة، كما أظهرت النتائج وجود علاقة ارتباطية موجبة دالة إحصائيًا لأساليب الحياة (المسيطر، المستحوذ، المتجنب اجتماعيًا) على الدرجة الكلية لأعراض اضطراب الشخصية الهستيرية، وعدم وجود علاقة ارتباطية لأسلوب الحياة (المفيد اجتماعيًا) مع الدرجة الكلية لأعراض اضطراب الشخصية الهستيرية.
الخلاصة: تتيح هذه النتائج فهمًا أفضل للتفاعلات بين أساليب الحياة واضطرابات الشخصية الهستيرية، مما يسهم في تحسين الفحص والتشخيص والتدخلات العلاجية لهذه الاضطرابات، ويشير الاكتساب المستفاد من هذه الدراسة إلى أهمية توجيه الاهتمام نحو تطوير برامج تدخل وتوعية تستهدف تحسين أساليب الحياة لدى الشباب الجامعي، مع التركيز بشكل خاص على تقديم أدوات واستراتيجيات لتعزيز الصحة النفسية وتقليل احتمالية تطوير أعراض اضطراب الشخصية الهستيرية، وفي ضوء هذه النتائج، توصي الباحثة بعقد المؤتمرات والندوات والورش التدريبية الجامعية التي تعزز أساليب الحياة الإيجابية للطلبة وتبصيريهم بأعراض اضطراب الشخصية الهستيرية.
دور مهارات القراءة الأولية للغة العربية في التنبؤ بمستوى الطلاقة في القراءة لدى تلاميذ الصف الثالث الابتدائي في المدارس الحكومية في قطر
Authors: Hassamien Elsayed Elshabrawi A. , Al-own Fatima Abdulla 
Published: May 2024

الأهداف: تهدف هذه الدراسة إلى الكشف عن دور مهارات القراءة الأولية للغة العربية في التنبؤ بالطلاقة القرائية لدى تلاميذ الصف الثالث الابتدائي في المدارس الحكومية في دولة قطر.
المنهجية: تبنت الدراسة المنهج الوصفي الارتباطي، حيث تم جمع بيانات الدراسة من خلال استخدام اختبار مهارات القراءة الأولية في اللغة العربية "Test of Early Arabic Literacy Skills (TEALS)" لقياس مهارات القراءة الأولية ومهارة قراءة الكلمات، واختبار لقياس مهارة الطلاقة القرائية على مستوى النصوص لتلاميذ الصف الثالث الابتدائي البالغ عددهم (200) تلميذًا، (100) من الإناث، و(100) من الذكور. تم اختيار مدرستين من بين المدارس الحكومية الابتدائية للبنات والمدارس النموذجية للبنين بشكل عشوائي. طبقت المقاييس بشكل فردي لكل تلميذ خلال ساعات الدوام الرسمي للتلاميذ.
النتائج: توصلت الدراسة إلى أن مهارتي المعالجة الصوتية وقواعد الإملاء والتهجئة تتسمان بأكبر نسبة من حجم التباين في التنبؤ بالطلاقة القرائية على مستوى الكلمات والنصوص.
الخلاصة: توصي الدراسة بالعمل على رفع مستوى التلاميذ في مهارات القراءة الأولية من خلال تهيئة البيئة التعليمية وتدريب المعلمين على تطبيق أفضل الأساليب والاستراتيجيات لتحقيق ذلك.
تقصّي الثبات لمقياس إستراتيجيات التعلّم المنظّم ذاتياً في ضوء النسب المفقودة وطرق تعويضها
Authors: Hijazi Taghreed 
Published: May 2024

الأهداف: هدفت هذه الدراسة إلى تقصي معاملي ثبات ألفا لكرونباخ وأوميغا لمكدونالد لمقياس استراتيجيات التعلم المنظم ذاتياً، وذلك في حالة عدم وجود قيم مفقودة، وفي حالة وجود قيم مفقودة بنسب مختلفة، ومعالجتها بطريقتي التعويض المتعدد، وتعظيم التوقّعات.
المنهجية: لتحقيق هدف الدراسة تم تطبيق مقياس إستراتيجيات التعلم المنظّم ذاتياً المكون من (77) فقرة على عينة تكونت من (980) طالباً وطالبة اختيروا بالطريقة العشوائية من طلبة البكالوريوس في مختلف التخصصات في جامعة اليرموك. وتم تطبيق إجراء الفقد تام العشوائية للبيانات بنسب (%5، %15، %30)، بعد ذلك تم تعويض النسب المفقودة بطريقتي تعظيم التوقع، والتعويض المتعدد، وحساب معاملات الثبات للمقياس وفق ألفا لكرونباخ وأوميغا لمكدونالد لكل موقف بحثي.
النتائج: أشارت نتائج الدراسة إلى أن قيم معاملات ألفا لكرونباخ وأوميغا لمكدونالد التي تم الحصول عليها عند استخدام طريقة تعظيم التوقّعات كانت أعلى منها عند استخدام طريقة التعويض المتعدّد، وذلك عند مختلف نسب الفقد (5%, 15%, 30%).
الخلاصة: تمت التوصية بتوجيه المزيد من الاهتمام للبيانات المفقودة في تصميم الدراسات وتحليل البيانات، والسعي لفهم أسباب فقدان البيانات، وتجنب الاختيار التعسفي لطرق التعامل مع البيانات المفقودة، واستخدام عدة طرق لتعويض البيانات المفقودة من أجل المقارنة، واستخدام معامل أوميغا لمكدونالد بدلاً من ألفا لكرونباخ.