bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential alterations of microrna expression in hepatocellular carcinoma development and venous metastasis
Authors: Wong Chun-Ming , Wong Carmen Chak-Lui , Lee Joyce Man-Fong , Fan Dorothy Ngo-Yin , Au Sandy Leung-Kuen , Ng Irene Oi-Lin 
Published: December 2011

Abstract

Hepatocellular carcinoma (HCC) is a prevalent cancer with an extremely high mortality rate attributed to HCC metastasis, which is the major cause of tumor recurrence and organ failure. Presence of tumor thrombi in the portal veins (venous metastases) is a clinicopathological feature of metastatic HCCs. In this study, we analyzed the microRNA (miRNA) expression profiles of nontumorous livers, primary HCCs, and venous metastases in the same livers from 20 HCC patients by way of TaqMan low-density array (TLDA) and identified the precise alterations of miRNA expression from nontumorous livers to primary HCCs and venous metastases globally. By unsupervised clustering analysis, nontumorous livers were distinctly segregated from primary HCCs and venous metastases, whereas no discernible difference in the expression pattern could be found between primary HCCs and venous metastases. However, a marked global reduction of miRNA expression levels was detected in venous metastases, as compared with primary HCCs. These data suggest that miRNA deregulation is an early event in liver carcinogenesis and the later global miRNA down-regulation aggravates the preexisting miRNA deregulation to further promote HCC metastasis.

Conclusion:

Our study has enriched the current understanding of the deregulation of miRNAs in HCC progression and highlighted the sequential and distinctive alterations of miRNA expression in primary HCC and venous metastasis formation. (Hepatology 2012;)
Aripiprazole plus divalproex for recently manic or mixed patients with bipolar I disorder: a 6‐month, randomized, placebo‐controlled, double‐blind maintenance trial
Authors: Woo Young Sup , Bahk Won‐Myong , Chung Moon Yong , Kim Do‐Hoon , Yoon Bo‐Hyun , Lee Jong Hun , Ahn Yong Min , Chung Sang‐Keun , Kim Jeong‐Gee , Lee Kwang Heun , Paik Ki‐Chung 
Published: December 2011

ObjectivesThe goal of this study was to investigate the safety and efficacy in preventing relapse of a mood episode in recently manic or mixed episode patients with bipolar I disorder stabilized with aripiprazole and divalproex combination.MethodsThis randomized, 24‐week, double‐blind, placebo‐controlled multicenter study enrolled patients from 23 centers in Korea. Patients with bipolar I disorder who had manic or mixed episode entered a 6‐week open‐label stabilization phase. After meeting stabilization criteria, 83 patients were randomly assigned to placebo + divalproex or aripiprazole + divalproex treatment group for the 24‐week, double‐blind maintenance phase.ResultsDuring the 6‐month double‐blind treatment, the time to relapse of any mood episode in the aripiprazole group was longer than the placebo group, but the difference did not reach statistical significance (p = 0.098). After controlling for mean divalproex level, the time to depressive episode relapse in the aripiprazole group was longer than those in the placebo group (p = 0.029). Weight gain (≥7% increase) occurred in 22.5% aripiprazole group and 18.6% placebo group (p = 0.787).ConclusionsIn this study, relapse of mood episode occurred fewer and later for aripiprazole with divalproex treatment than divalproex monotherapy, but the differences were not statistically significant. Copyright © 2011 John Wiley & Sons, Ltd.
Vascular endothelial growth factor (VEGF) gene polymorphisms may influence the efficacy of thalidomide in multiple myeloma
Authors: Andersen Niels F. , Vogel Ulla , Klausen Tobias W. , Gimsing Peter , Gregersen Henrik , Abildgaard Niels , Vangsted Annette J. 
Published: December 2011

AbstractVascular endothelial growth factor (VEGF) is a potent proangiogenic factor. Several single nucleotide polymorphisms (SNPs) in the VEGF gene with influence on VEGF expression have been described. In multiple myeloma, VEGF stimulates angiogenesis which is correlated with disease progression and prognosis. In this study, we evaluated the association between genetic variations in the VEGF gene in patients with multiple myeloma and time to treatment failure (TTF) after high‐dose melphalan and stem cell support (HDT), overall survival (OS) and efficacy of the anti‐angiogenic drug thalidomide. Retrospectively, the SNPs −2,578C>A (rs699947), −460C>T (rs833061), +405G>C (rs2010963) and +936C>T (rs3025039) in the VEGF gene were examined in 348 patients with newly diagnosed multiple myeloma initially treated with HDT, where 176 patients were treated with thalidomide at relapse. None of the examined geno‐ or haplotypes was associated with differences in TTF after initial therapy or OS. A possible relation between the haplotype −2,578A/−460C/+405G (ACG) and effect of thalidomide was seen. Patients with no copies of the haplotype ACG had a longer time to next treatment than patients with one or two copies of the haplotype ACG, median 13.7 months vs. 9.2 months, p = 0.007. In conclusion, the haplotype ACG in the VEGF gene may influence the efficacy of thalidomide in multiple myeloma. Further analyses are needed to confirm these findings and get insight into the functional effect of these polymorphisms, so in the future we may be able to select multiple myeloma patients who especially will benefit from treatment with thalidomide.
Potentiation of a p53‐SLP vaccine by cyclophosphamide in ovarian cancer: A single‐arm phase II study
Authors: Vermeij Renee , Leffers Ninke , Hoogeboom Baukje‐Nynke , Hamming Ineke L.E. , Wolf Rinze , Reyners Anna K.L. , Molmans Barbara H.W. , Hollema Harry , Bart Joost , Drijfhout Jan W. , Oostendorp Jaap , van der Zee Ate G.J. , Melief Cornelis J. , van der Burg Sjoerd H. , Daemen Toos , Nijman Hans W. 
Published: December 2011

AbstractThe purpose of the current phase II single‐arm clinical trial was to evaluate whether pretreatment with low‐dose cyclophosphamide improves immunogenicity of a p53‐synthetic long peptide (SLP) vaccine in patients with recurrent ovarian cancer. Patients with ovarian cancer with elevated serum levels of CA‐125 after primary treatment were immunized four times with the p53‐SLP vaccine. Each immunization was preceded by administration of 300 mg/m2 intravenous cyclophosphamide as a means to affect regulatory T cells (Tregs). Vaccine‐induced p53‐specific interferon‐gamma (IFN‐γ)‐producing T cells evaluated by IFN‐γ ELISPOT were observed in 90% (9/10) and 87.5% (7/8) of evaluable patients after two and four immunizations, respectively. Proliferative p53‐specific T cells, observed in 80.0% (8/10) and 62.5% (5/8) of patients, produced both T‐helper 1 and T‐helper‐2 cytokines. Cyclophosphamide induced neither a quantitative reduction of Tregs determined by CD4+FoxP3+ T cell levels nor a demonstrable qualitative difference in Treg function tested in vitro. Nonetheless, the number of vaccine‐induced p53‐specific IFN‐γ‐producing T cells was higher in our study compared to a study in which a similar patient group was treated with p53‐SLP monotherapy (p ≤ 0.012). Furthermore, the strong reduction in the number of circulating p53‐specific T cells observed previously after four immunizations was currently absent. Stable disease was observed in 20.0% (2/10) of patients, and the remainder of patients (80.0%) showed clinical, biochemical and/or radiographic evidence of progressive disease. The outcome of this phase II trial warrants new studies on the use of low‐dose cyclophosphamide to potentiate the immunogenicity of the p53‐SLP vaccine or other antitumor vaccines.
Effect of fiber alignment in electrospun scaffolds on keratocytes and corneal epithelial cells behavior
Authors: Yan Jing , Qiang Linhui , Gao Yan , Cui Xuejun , Zhou Hongyan , Zhong Shuangling , Wang Qing , Wang Hongyan 
Published: December 2011

AbstractThe contribution of fiber alignment of scaffold on cellular mechanisms was evaluated by a comparative study of two different cells sourced from cornea. Electrospun scaf‐folds with similar composition and comparable fiber size were fabricated into randomly oriented and aligned scaffolds, which bear paralleled degradation of gelatin. Tensile test of wet scaffolds indicated that fiber alignment could influence its mechanical properties. Due to the unidirectional fiber orientation, aligned scaffold exhibited higher tensile modulus, higher break strength, and lower elongation at break than randomly oriented scaffold. The effect of fiber alignment on cells behavior was evaluated by cell morphology, specific protein expression, adhesion, and proliferation. Different corneal cells responded uniquely to fiber alignment of scaffold, keratocytes interacting more favorably on alignment scaffold and corneal epithelial cells more favorably on randomly oriented scaffold. These results confirmed that fiber alignment of scaffold would be benefit for cell proliferation if its contact guidance coincided with the cell shape and cytoskeletal tension. This finding is important to envisage an advanced composite scaffold that incorporates randomly oriented and aligned fibers for the growth and control of different cell types required for the successful development of corneal grafts by tissue engineering. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2012.
The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells
Authors: Kim Tae‐Dong , Shin Sook , Berry William L. , Oh Sangphil , Janknecht Ralf 
Published: December 2011

AbstractJMJD2A is a transcriptional cofactor and enzyme that catalyzes demethylation of histone H3 lysines 9 and 36 and is overexpressed in human tumors, but its role in oncogenesis remains unclear. Here, we show that JMJD2A interacts with the tumor suppressor p53 both in vitro and in HCT116 colon cancer cells. Chromatin immunoprecipitation assays demonstrated that JMJD2A was recruited together with p53 to the promoter of the p21 cell cycle inhibitor upon stimulation with the DNA damaging agent, adriamycin. Downregulation of JMJD2A resulted in increased expression of p21 and of the pro‐apoptotic Puma protein, whereas levels of the anti‐apoptotic Bcl‐2 protein were decreased. Furthermore, JMJD2A knock‐down led to reduced HCT116, DLD‐1 and HT‐29 colon cancer cell proliferation, while overexpression of JMJD2A enhanced HCT116 proliferation in low serum media. Finally, JMJD2A depletion induced apoptosis in HCT116 cells and this effect was less pronounced in the absence of p53. Collectively, these data indicate that JMJD2A is a novel promoter of colon cancer cell proliferation and survival, which mediates its effects in p53‐dependent and ‐independent ways. JMJD2A may therefore be a valid target to sensitize tumor cells to chemotherapy‐induced cell death and growth suppression. J. Cell. Biochem. 113: 1368–1376, 2012. © 2011 Wiley Periodicals, Inc.
The Hamilton‐Waterloo problem for Hamilton cycles and triangle‐factors
Authors: Lei Hongchuan , Shen Hao 
Published: December 2011

AbstractIn this article, we consider the Hamilton‐Waterloo problem for the case of Hamilton cycles and triangle‐factors when the order of the complete graph Kn is even. We completely solved the problem for the case n≡24 (mod 36). For the cases n≡0 (mod 18) and n≡6 (mod 36), we gave an almost complete solution. © 2012 Wiley Periodicals, Inc. J. Combin. Designs 20: 305–316, 2012
Between‐Session Practice and Therapeutic Alliance as Predictors of Mindfulness After Mindfulness‐Based Relapse Prevention
Authors: Bowen Sarah , Kurz Andrew S. 
Published: December 2011

ObjectivesMindfulness‐based treatments have demonstrated efficacy in reducing symptoms in clinical populations. Not surprisingly, research suggests increases in client mindfulness might be a mechanism of change in these treatments. However, little is known about specific factors that lead to increased mindfulness.DesignThe present study is a secondary analysis of 93 adults in outpatient treatment for substance abuse, assessing effects of between‐session mindfulness practice and therapeutic alliance on levels of mindfulness after an 8‐week Mindfulness‐Based Relapse Prevention (MBRP) program.ResultsBetween‐session practice over the course of the 8 weeks was predictive of mindfulness at postcourse, although not at the 2‐month or 4‐month follow‐up assessments. Client‐rated therapeutic alliance was a significant predictor at the 2‐month follow‐up, although not at 4 months.ConclusionsThese findings suggest that between‐session practice and therapeutic alliance might be important factors in the initial increases in mindfulness after mindfulness‐based treatments, but factors supporting longer term mindfulness might shift over time.
Understanding suicide risk: identification of high‐risk groups during high‐risk times
Authors: Overholser James C. , Braden Abby , Dieter Lesa 
Published: December 2011

AbstractBackgroundThe assessment of suicide risk is a complex task for mental health professionals. Certain demographic groups are associated with completed suicide including males, divorced adults, and Caucasians. However, demographic variables alone provide a crude assessment of suicide risk. Psychiatric diagnosis and recent life events might improve the identification of high‐risk individuals.MethodThe current study evaluated 148 individuals who died by suicide compared with 257 adults who died suddenly from accidents or medical problems. Psychological autopsy was used to assess Axis I psychiatric diagnosis and recent stressful life events. Results: Suicide completers were significantly more likely than comparison subjects to have a depressive disorder, a substance abuse disorder, and to have experienced interpersonal conflict in the months leading up to their death. A discriminant function analysis revealed that the combination of demographic variables, recent stressful life events, and psychiatric diagnoses best discriminated between suicide completers and comparison subjects.ConclusionsProper assessment of suicide risk should include a comprehensive evaluation of demographic characteristics, recent life stressors, and psychiatric diagnosis.
Pancyclic subgraphs of random graphs
Authors: Lee Choongbum , Samotij Wojciech 
Published: December 2011

AbstractAn n‐vertex graph is called pancyclic if it contains a cycle of length t for all 3≤t≤n. In this article, we study pancyclicity of random graphs in the context of resilience, and prove that if p>n−1/2, then the random graph G(n, p) a.a.s. satisfies the following property: Every Hamiltonian subgraph of G(n, p) with more than edges is pancyclic. This result is best possible in two ways. First, the range of p is asymptotically tight; second, the proportion of edges cannot be reduced. Our theorem extends a classical theorem of Bondy, and is closely related to a recent work of Krivelevich et al. The proof uses a recent result of Schacht (also independently obtained by Conlon and Gowers). © 2011 Wiley Periodicals, Inc.
Combinatorial roles of extrinsic and intrinsic muscles in extension strength of the distal interphalangeal joint
Authors: Murai Shinji , Tanaka Toshikazu , Aoki Mitsuhiro 
Published: December 2011

AbstractIn this study, we observed a combinatorial relationship between intrinsic and extrinsic muscles to extend the distal phalanx via the terminal tendon of the finger extensor. Eleven fresh‐frozen human cadaver digit rays were used in these experiments (four index, four middle, three ring digits). All fingers had full joint motion without degenerative diseases. Fingers were individually mounted in a custom built jig fixed by a 1‐mm Kirschner wire that was driven into the rotational center of the distal interphalangeal (DIP) and proximal interphalangeal joints. Loads were applied to the extensor digit and dorsal interosseous tendons without flexor tendons, via sutures attached over low‐friction pulleys. Extension forces that crossed the DIP joint were measured by a force transducer coupled with a materials‐testing machine. We observed a steep inclination of the extensor forces produced by the intrinsic muscles, and there were no significant differences in comparisons among loads (200, 400, 600, and 800 g). The inclination slope increased with an increase of load (p < 0.001). Additionally, the inclinations of the non‐linear phases among all finger types were not statistically different. Thus, the contribution between the extrinsic and intrinsic muscles in providing extensor forces to the distal phalanx was similar. © 2011 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:893–896, 2012
High‐Arctic climate conditions for the last 7000 years inferred from multi‐proxy analysis of the Bliss Lake record, North Greenland
Authors: Olsen Jesper , Kjær Kurt H. , Funder Svend , Larsen Nicolaj K. , Ludikova Anna 
Published: December 2011

AbstractThe Arctic is more vulnerable to climate change than are mid latitudes. Therefore, palaeolimnological studies from the High Arctic are important in providing insights into the dynamics of the climate system. Here we present a multi‐proxy study from one of the world's northernmost lakes: Bliss Lake, Peary Land, Greenland. The early Holocene (10 850–10 480 cal. a BP) is characterized by increased erosion and gradually more marine conditions. Full marine conditions developed from 10 480 cal. a BP until the lake was isolated at 7220 cal. a BP. From its marine isolation at 7220 cal. a BP Bliss Lake becomes a lacustrine environment. Evidence from geochemical proxies (δ13C and total organic carbon) suggests that warmer conditions prevailed between 7220 and 6500 cal. a BP, corresponding to the Holocene thermal maximum, and from 3300 until 910 cal. a BP. From 850 to 500 cal. a BP colder climate conditions persisted. The transition from warmer to colder climate conditions taking place around 850 cal. a BP may be associated with the transition from the Medieval Warm Period to the Little Ice Age. Copyright © 2011 John Wiley & Sons, Ltd.
Determination of sulfonamides in livers using matrix solid‐phase dispersion extraction high‐performance liquid chromatography
Authors: Zhang Yupu , Xu Xu , Qi Xiao , Gao Wenquan , Sun Shuo , Li Xiaotian , Jiang Chengfei , Yu Aimin , Zhang Hanqi , Yu Yong 
Published: December 2011

AbstractThe matrix solid‐phase dispersion (MSPD) was applied for extracting seven sulfonamides (SAs) in liver samples. The separation and determination were carried out by high‐performance liquid chromatography. The analytes were derivated with fluorescamine and detected with fluorescence detector. The types of dispersion adsorbents for MSPD were examined and the highest recovery was obtained when the diatomaceous earth was used as the dispersion adsorbent and the mass ratio of dispersion adsorbent to sample was 3:1. The acetone was used as the elution solvent. Under the optimal conditions, the linear range for determining the SAs in liver samples was 5.0–1000.0 ng/g. The porcine, chicken and cattle liver samples were analyzed and the average recoveries of seven SAs were higher than 84.6%.
Photonic chip based ultrafast optical processing based on high nonlinearity dispersion engineered chalcogenide waveguides
Authors: Eggleton B.J. , Vo T.D. , Pant R. , Schr J. , Pelusi M.D. , Yong Choi D. , Madden S.J. , Luther‐Davies B. 
Published: December 2011

AbstractProgress in developing photonic chip based optical processing devices with ultrahigh‐bandwidth is reviewed. The unprecedented processing bandwidth of our platform based on dispersion engineered chalcogenide waveguides is exploited to perform Tbaud optical switching and performance monitoring. Recent experiments and demonstrations of photonic logic operations are reviewed.
Novel Functional Conjugative Hyperbranched Polymers with Aggregation‐Induced Emission: Synthesis Through One‐Pot “A2+B4” Polymerization and Application as Explosive Chemsensors and PLEDs
Authors: Wu Wenbo , Ye Shanghui , Yu Gui , Liu Yunqi , Qin Jingui , Li Zhen 
Published: December 2011

AbstractWith the aim to develop new tetraphenylethylene (TPE)‐based conjugated hyperbranched polymer, TPE units, one famous aggregation‐induced emission (AIE) active group, are utilized to construct hyperbranched polymers with three other aromatic blocks, through an “A2+B4” approach by using one‐pot Suzuki polycondensation reaction. These three hyperbranched polymers exhibit interesting AIEE behavior and act as explosive chemsensors with high sensitivity both in the nanoparticles and solid states. This is the first report of the AIE activity of the TPE‐based conjugated hyperbranched polymers. Their corresponding PLED devices also demonstrate good performance.
Synthesis and Characterization of 2,7‐Linked Carbazole Oligomers
Authors: Qin Ruiping , Bo Zhishan 
Published: December 2011

AbstractA set of monodisperse 2,7‐linked carbazole oligomers (3‐mer, 5‐mer, 7‐mer, and 9‐mer) was synthesized, and their photophysical, electrochemical, and thermal properties were investigated. In solutions, these oligomers exhibited bright blue emission with almost quantitative fluorescence quantum yield. The emission spectra of these oligomers in films are quite different. 3‐Mer and 5‐mer exhibited featureless emission spectra, whereas 7‐mer and 9‐mer showed well‐resolved emission spectra.
Therapeutic Use of Creatine in Brain or Heart Ischemia: Available Data and Future Perspectives
Authors: Perasso Luisa , Spallarossa Paolo , Gandolfo Carlo , Ruggeri Piero , Balestrino Maurizio 
Published: December 2011

AbstractCreatine (Cr) is essential in safeguarding ATP levels and in moving ATP from its production site (mitochondria) to the cytoplasmic regions where it is used. Moreover, it has effects unrelated to energy metabolism, such as free radical scavenging, antiapoptotic action, and protection against excitotoxicity. Recent research has studied Cr‐derived compounds (Cr benzyl ester and phos‐pho–Cr–magnesium complex) that reproduce the neuroprotective effects of Cr while better crossing the neuronal plasma membrane and, hopefully, the blood–brain barrier (BBB). Intracellular levels of Cr can be increased by incubation with Cr or some of its derivatives, and this increase is protective against anoxic or ischemic damage. A large amount of experimental evidence shows that pretreatment with Cr is capable of reducing the damage induced by ischemia or anoxia in both heart and brain, and that such treatment may also be useful even after stroke or myocardial infarction (MI) has already occurred. Cr has been safely administered to patients affected by several neurological diseases, yet it has never been tested in human brain ischemia, the condition where its rationale is strongest. Phosphocreatine (PCr) has been administered after human MI, where it proved to be safe and probably helpful. Cr should be tested in the prophylactic protection against human brain ischemia and either Cr or PCr should be further tested in MI. Moreover, Cr‐ or PCr‐derived drugs should be developed in order to overcome these molecules’ limitations in crossing the BBB and the cell plasma membrane.