bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co-phylogeographic structure in a disease-causing parasite and its oyster host
Authors: Weatherup Elizabeth Faye , Carnegie Ryan , Strand Allan E. , Sotka Erik E. 
Published: May 2024

AbstractWith the increasing affordability of next-generation sequencing technologies, genotype-by-sequencing has become a cost-effective tool for ecologists and conservation biologists to describe a species' evolutionary history. For host–parasite interactions, genotype-by-sequencing can allow the simultaneous examination of host and parasite genomes and can yield insight into co-evolutionary processes. The eastern oyster, Crassostrea virginica, is among the most important aquacultured species in the United States. Natural and farmed oyster populations can be heavily impacted by ‘dermo’ disease caused by an alveolate protist, Perkinsus marinus. Here, we used restricted site-associated DNA sequencing (RADseq) to simultaneously examine spatial population genetic structure of host and parasite. We analysed 393 single-nucleotide polymorphisms (SNPs) for P. marinus and 52,100 SNPs for C. virginica from 36 individual oysters from the Gulf of Mexico (GOM) and mid-Atlantic coastline. All analyses revealed statistically significant genetic differentiation between the GOM and mid-Atlantic coast populations for both C. virginica and P. marinus, and genetic divergence between Chesapeake Bay and the outer coast of Virginia for C. virginica, but not for P. marinus. A co-phylogenetic analysis confirmed significant coupled evolutionary change between host and parasite across large spatial scales. The strong genetic divergence between marine basins raises the possibility that oysters from either basin would not be well adapted to parasite genotypes and phenotypes from the other, which would argue for caution with regard to both oyster and parasite transfers between the Atlantic and GOM regions. More broadly, our results demonstrate the potential of RADseq to describe spatial patterns of genetic divergence consistent with coupled evolution.
Expanding on expansus: a new species of Scaphanocephalus from North America and the Caribbean based on molecular and morphological data
Authors: Locke Sean A. , Calhoun Dana M. , Valencia Cruz José M. , Ebbs Erika T. , Díaz Pernett Sandra C. , Tkach Vasyl V. , Kinsella John M. , Freeman Mark A. , Blanar Christopher A. , Johnson Pieter T. J. 
Published: May 2024

AbstractMembers of the genus Scaphanocephalus mature in accipitrids, particularly osprey, Pandion haliaetus, with metacercaria causing Black Spot Syndrome in reef fishes. In most of the world, only the type species, Scaphanocephalus expansus (Creplin, 1842) has been reported. Recent molecular studies in the Western Atlantic, Mediterranean and Persian Gulf reveal multiple species of Scaphanocephalus, but have relied on 28S rDNA, mainly from metacercariae, which limits both morphological identification and resolution of closely related species. Here we combine nuclear rDNA with mitochondrial sequences from adult worms collected in osprey across North America and the Caribbean to describe species and elucidate life cycles in Scaphanocephalus. A new species described herein can be distinguished from S. expansus based on overall body shape and size. Phylogenetic analysis of the whole mitochondrial genome of Scaphanocephalus indicates a close relationship with Cryptocotyle. We conclude that at least 3 species of Scaphanocephalus are present in the Americas and 2 others are in the Old World. Specimens in the Americas have similar or identical 28S to those in the Mediterranean and Persian Gulf, but amphi-Atlantic species are unlikely in light of divergence in cytochrome c oxidase I and the lack of amphi-Atlantic avian and fish hosts. Our results provide insight into the geographic distribution and taxonomy of a little-studied trematode recently linked to an emerging pathology in ecologically important reef fishes.
Creativity is motivated by novelty. Curiosity is triggered by uncertainty
Authors: Singh Aditya , Murayama Kou 
Published: May 2024

Abstract
Although creativity and curiosity can be similarly construed as knowledge-building processes, their underlying motivation is fundamentally different. Specifically, curiosity drives organisms to seek information that reduces uncertainty so that they can make a better prediction about the world. On the contrary, creative processes aim to connect distant pieces of information, maximizing novelty and utility.
Expanding horizons in reinforcement learning for curious exploration and creative planning
Authors: Zhou Dale , Bornstein Aaron M. 
Published: May 2024

Abstract
Curiosity and creativity are expressions of the trade-off between leveraging that with which we are familiar or seeking out novelty. Through the computational lens of reinforcement learning, we describe how formulating the value of information seeking and generation via their complementary effects on planning horizons formally captures a range of solutions to striking this balance.
A developmental account of curiosity and creativity
Authors: Vaisarova Julie , Lucca Kelsey 
Published: May 2024

Abstract
Ivancovsky et al.'s Novelty-Seeking Model suggests several mechanisms that might underlie developmental change in creativity and curiosity. We discuss how these implications both do and do not align with extant developmental findings, suggest two further elements that can provide a more complete developmental account, and discuss current methodological barriers to formulating an integrated developmental model of curiosity and creativity.
Distinct neurocognitive pathways underlying creativity: An integrative approach
Authors: Baas Matthijs , Stevenson Claire E. , Perchtold-Stefan Corinna , Nijstad Bernard A. , De Dreu Carsten K. W. 
Published: May 2024

Abstract
By examining the shared neuro-cognitive correlates of curiosity and creativity, we better understand the brain basis of creativity. However, by only examining shared components, important neuro-cognitive correlates are overlooked. Here, we argue that any comprehensive brain model of creativity should consider multiple cognitive processes and, alongside the interplay between brain networks, also the neurochemistry and neural oscillations that underly creativity.
Question-asking as a mechanism of information seeking
Authors: Raz Tuval , Kenett Yoed N. 
Published: May 2024

Abstract
Ivancovsky et al. explore the relationship between curiosity and creativity, by suggesting they align through novelty-seeking mechanisms. We argue that a general mechanism linking both capacities together is question-asking: Curiosity drives question-asking that leads to creative problem solving. Yet, current findings from our lab suggest that question complexity relates to creativity, but not necessarily to curiosity, warranting further investigation.
A shared “optimal-level of arousal”: Seeking basis for creativity and curiosity
Authors: Gustafsson Erik , Ibáñez de Aldecoa Paula , Burdett Emily R R 
Published: May 2024

Abstract
We argue that the phases identified in the novelty-seeking model can be clarified by considering an updated version of the optimal-level of arousal model, which incorporates the “arousal” and “mood changing” potentials of stimuli and contexts. Such a model provides valuable insights into what determines one's state of mind, inter-individual differences, and the rewarding effects of curiosity and creativity.
Household transmission of human metapneumovirus and seasonal coronavirus
Authors: Bell Cristalyne , He Cecilia , Norton Derek , Goss Maureen , Chen Guanhua , Temte Jonathan 
Published: May 2024

Abstract
We analyzed data from a community-based acute respiratory illness study involving K-12 students and their families in southcentral Wisconsin and assessed household transmission of two common seasonal respiratory viruses – human metapneumovirus (HMPV) and human coronaviruses OC43 and HKU1 (HCOV). We found secondary infection rates of 12.2% (95% CI: 8.1%–17.4%) and 19.2% (95% CI: 13.8%–25.7%) for HMPV and HCOV, respectively. We performed individual- and family-level regression models and found that HMPV transmission was positively associated age of the index case (individual model: p = .016; family model: p = .004) and HCOV transmission was positively associated with household density (family model: p = .048). We also found that the age of the non-index case was negatively associated with transmission of both HMPV (individual model: p = .049) and HCOV (individual model: p = .041), but we attributed this to selection bias from the original study design. Understanding household transmission of common respiratory viruses like HMPV and HCOV may help to broaden our understanding of the overall disease burden and establish methods to prevent the spread of disease from low- to high-risk populations.
Codes of Conduct at Political Science Conferences: Prevalence and Content
Authors: Lu Lucie , Webb Williams Nora 
Published: May 2024

ABSTRACTAcademic conferences are important institutions for promoting new research and facilitating conversations about the field. As a venue for knowledge exchange, professional development, and networking, conferences ideally promote positive environments that make scholars from underrepresented groups feel welcome. Yet, negative experiences at conferences are well documented. Codes of conduct have been promoted as tools to reduce harassment and discrimination. This article examines the prevalence and content of codes at US-based political science conferences and workshops. More specifically, we analyze whether and how codes address issues of sexual misconduct and identity-based discrimination. We find that 19% of 177 surveyed conferences have a code of conduct. Conferences that are older and larger are more likely to have codes, as are conferences that are run by organizations with permanent staff and relevant committees. We argue that effective conference codes must contain definitions, reporting channels, and enforcement procedures. Many of the analyzed codes did not explicitly define prohibited behaviors, specify mechanisms to report code violations, or describe consequences for misconduct.
AffineMortality: An R package for estimation, analysis, and projection of affine mortality models
Authors: Ungolo Francesco , Garces Len Patrick Dominic M. , Sherris Michael , Zhou Yuxin 
Published: May 2024

AbstractThis paper presents the AffineMortality R package which performs parameter estimation, goodness-of-fit analysis, simulation, and projection of future mortality rates for a set of affine mortality models for use in pricing and reserving. The computational routines build on the univariate Kalman Filtering approach of Koopman and Durbin ((2000). Journal of Time Series Analysis,21(3), 281–296.) along other numerical methods to enhance the robustness of the results. This paper provides a discussion of how the package works in order to effectively estimate and project survival curves, and describes the available functions. Illustration of the package for mortality analysis of the US male data set is provided.
On the benefits of pension plan consolidation: Understanding the impact of full plan mergers
Authors: Bégin Jean-François , Sanders Barbara , Zhou Wenyuan 
Published: May 2024

AbstractThis study investigates the benefits and drawbacks of pension plan consolidation by quantifying the impact of mergers of heterogeneous plans on different stakeholders in a unique Canadian implementation of defined benefit plans. Using a comprehensive framework that combines a realistic economic scenario generator, a stochastic mortality model that captures differences among subpopulations, a cost model with economies of scale, and a dynamic asset allocation methodology, we evaluate the combined effect of asset- and liability-side changes on three groups of measures: plan-related risk measures assessing profits from an economic capital perspective, consumption-based metrics to understand the impact on members, and contribution risk measures capturing the risk from the employer’s viewpoint. We apply the framework to a hypothetical and empirically relevant merger and find that consolidation is favorable under most circumstances: the positive impacts of better diversification and economies of scale continue to outweigh the negative effects of heterogeneity even when the merging plans have different mortality expectations, different maturity levels, or modest differences in initial funded ratios.
Pockmarks Offshore Big Sur, California Provide Evidence for Recurrent, Regional, and Unconfined Sediment Gravity Flows
Authors: Lundsten E. , Paull C. K. , Gwiazda R. , Dobbs S. , Caress D. W. , Kuhnz L. A. , Walton M. , Nieminski N. , McGann M. , Lorenson T. , Cochrane G. , Addison J. 
Published: May 2024

AbstractRecent surface ship multibeam surveys of the Sur Pockmark Field, offshore Central California, reveal >5,000 pockmarks in an area that is slated to host a wind farm, between 500‐ and 1,500‐m water depth. Extensive fieldwork was conducted to characterize the seafloor environment and its recent geologic history, including visual observations with remotely operated vehicles, sediment core sampling, and high‐resolution, near‐bottom Chirp and multibeam surveys collected with autonomous underwater vehicles to capture the morphology and stratigraphy of the pockmarks. No evidence of high methane concentrations in sediments, chemosynthetic biological communities, or methane‐derived diagenetic byproducts was found. Chirp data and sediment cores showed alternating layers of slowly accumulating hemipelagic drapes interrupted by more reflective turbidite horizons that extend throughout the pockmark field and beyond. Chirp data showed multiple episodes of lateral migration over time in some of the pockmarks in association with erosion and infilling events. Laterally continuous turbidite horizons that overlay erosional surfaces indicated that pockmark migration occurred synchronously in multiple pockmarks separated by tens of kilometers. These shifts are presumed to be the result of asymmetrical erosion of the pockmark flanks caused by passing sediment gravity flows. While some pockmarks occur in chains, most are not clustered or randomly spaced but are regularly dispersed within the pockmark field. We hypothesize that intermittent, unconfined sediment gravity flows occurring over at least the last 280,000 years are the source of the regionally continuous turbidite deposits and the mechanism that maintained the regularly dispersed pockmarks.
δ18O of Marine‐Influenced Tectona grandis L. f. From Equatorial Indonesia: A Local Rainfall Amount and Remote ENSO Indicator
Authors: Nurhati I. S. , Evans M. N. , Cahyarini S. Y. , D’Arrigo R. D. , Yoshimura K. , Herho S. H. S. 
Published: May 2024

AbstractThe hydroclimatic response of the El Niño‐Southern Oscillation (ENSO) to external radiative forcing remains controversial and difficult to project with confidence for the 21st century. Annually resolved paleoclimatic reconstructions spanning the pre‐ and post‐industrial eras from the Indonesian maritime continent may provide hindcasting and diagnostic targets. Here we report δ18O observations from dendrochronologically dated teak (Tectona grandis L. f.) α‐cellulose samples collected at Muna Island, Sulawesi (5.3°S, 123°E, elevation 10 m), for November‐April growing seasons during the period 1969/70–2004/5. Age‐modeled, annually averaged α‐cellulose δ18O anomalies are significantly correlated with simulated α‐cellulose δ18O at the study site. We show that the correlation is largely explained by the amount effect in local and regional precipitation δ18O. Significant correlation with SST anomalies over the study period suggest that replicated multicentury α‐cellulose records from this archive may be interpreted as ENSO indicators.
Combustion Completeness and Sample Location Determine Wildfire Ash Leachate Chemistry
Authors: Campbell Micheline , Treble Pauline C. , McDonough Liza K. , Naeher Sebastian , Baker Andy , Grierson Pauline F. , Wong Henri , Andersen Martin S. 
Published: May 2024

AbstractUnderstanding past fire regimes and how they vary with climate, human activity, and vegetation patterns is fundamental to the mitigation and management of changing fire regimes as anthropogenic climate change progresses. Ash‐derived trace elements and pyrogenic biomarkers from speleothems have recently been shown to record past fire activity in speleothems from both Australia and North America. This calls for an empirical study of ash geochemistry to aid the interpretation of speleothem palaeofire proxy records. Here we present analyses of leached ashes collected following fires in southwest and southeast Australia. We include a suite of inorganic elemental data from the water‐soluble fraction of ash as well as a selection of organic analytes (pyrogenic lipid biomarkers). We also present elemental data from leachates of soils collected from sites in southwest Australia. We demonstrate that the water‐soluble fraction of ash differs from the water‐soluble fraction of soils, with trace and minor element concentrations in ash leachates varying with combustion completeness (burn severity) and sample location. Changes in some lipid biomarker concentrations extracted from ashes may reflect burn severity. Our results contribute to building a process‐based understanding of how speleothem geochemistry may record fire frequency and severity, and suggest that more research is needed to understand the transport pathways for the inclusion of pyrogenic biomarkers in speleothems. Our results also demonstrate that potential contaminant loads from ashes are much higher than from soils, with implications for the management of karst catchments, which are a critical water resource.
Transcription factor activating enhancer-binding protein 2ε (AP2ε) modulates phenotypic plasticity and progression of malignant melanoma
Authors: Staebler Sebastian , Rottensteiner-Brandl Ulrike , El Ahmad Zubeir , Kappelmann-Fenzl Melanie , Arkudas Andreas , Kengelbach-Weigand Annika , Bosserhoff Anja-Katrin , Schmidt Sonja K. 
Published: May 2024

AbstractMalignant melanoma, the most aggressive form of skin cancer, is often incurable once metastatic dissemination of cancer cells to distant organs has occurred. We investigated the role of Transcription Factor Activating Enhancer-Binding Protein 2ε (AP2ε) in the progression of metastatic melanoma. Here, we observed that AP2ε is a potent activator of metastasis and newly revealed AP2ε to be an important player in melanoma plasticity. High levels of AP2ε lead to worsened prognosis of melanoma patients. Using a transgenic melanoma mouse model with a specific loss of AP2ε expression, we confirmed the impact of AP2ε to modulate the dynamic switch from a migratory to a proliferative phenotype. AP2ε deficient melanoma cells show a severely reduced migratory potential in vitro and reduced metastatic behavior in vivo. Consistently, we revealed increased activity of AP2ε in quiescent and migratory cells compared to heterogeneously proliferating cells in bioprinted 3D models. In conclusion, these findings disclose a yet-unknown role of AP2ε in maintaining plasticity and migration in malignant melanoma cells.
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis
Authors: Luo Jingjing , Yang Yang , Zhang Guang , Fang Debao , Liu Kaiyue , Mei Yide , Wang Fang 
Published: May 2024

AbstractCancer cells undergo metabolic reprogramming in response to hostile microenvironments, such as energy stress; however, the underlying mechanisms remain largely unclear. It is also unknown whether energy stress-responsive circular RNA (circRNA) is involved in the regulation of glucose metabolism. Here we report that circDDX21 is upregulated in response to glucose deprivation by the transcription factor c-Myc. Functionally, circDDX21 is shown to promote glycolysis by increasing PGAM1 expression. Mechanistically, circDDX21 interacts with the RNA binding protein PABPC1, disrupting its association with the ubiquitin E3 ligase MKRN3. This disassociation attenuates MKRN3-mediated PABPC1 ubiquitination and enhances the binding of PABPC1 to PGAM1 mRNA, thereby leading to PGAM1 mRNA stabilization. The ability of the circDDX21-PGAM1 axis to promote hepatocellular carcinogenesis is validated in a xenograft mouse model. Additionally, in clinical hepatocellular carcinoma tissues, there is a positive correlation between circDDX21 and PGAM1 expression. These findings establish circDDX21 as an important regulator of glycolysis and suggest circDDX21 as a potential therapeutic target for hepatocellular carcinoma.
Ferroptosis exacerbates hyperlipidemic acute pancreatitis by enhancing lipid peroxidation and modulating the immune microenvironment
Authors: Gu Xinyi , Huang Zhicheng , Ying Xiuzhiye , Liu Xiaodie , Ruan Kaiyi , Hua Sijia , Zhang Xiaofeng , Jin Hangbin , Liu Qiang , Yang Jianfeng 
Published: May 2024

AbstractAbnormal activation of ferroptosis worsens the severity of acute pancreatitis and intensifies the inflammatory response and organ damage, but the detailed underlying mechanisms are unknown. Compared with other types of pancreatitis, hyperlipidemic acute pancreatitis (HLAP) is more likely to progress to necrotizing pancreatitis, possibly due to peripancreatic lipolysis and the production of unsaturated fatty acids. Moreover, high levels of unsaturated fatty acids undergo lipid peroxidation and trigger ferroptosis to further exacerbate inflammation and worsen HLAP. This paper focuses on the malignant development of hyperlipidemic pancreatitis with severe disease combined with the core features of ferroptosis to explore and describe the mechanism of this phenomenon and shows that the activation of lipid peroxidation and the aberrant intracellular release of many inflammatory mediators during ferroptosis are the key processes that regulate the degree of disease development in patients with HLAP. Inhibiting the activation of ferroptosis effectively reduces the intensity of the inflammatory response, thus reducing organ damage in patients and preventing the risk of HLAP exacerbation. Additionally, this paper summarizes the key targets and potential therapeutic agents of ferroptosis associated with HLAP deterioration to provide new ideas for future clinical applications.
TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes
Authors: Cheng I-Hsin , Pi Wen-Chieh , Hsu Chung-Hao , Guo Yiran , Lai Jun-Lin , Wang Gang G. , Chung Bon-chu , Roeder Robert G. , Chen Wei-Yi 
Published: May 2024

AbstractTFIID, one of the general transcription factor (GTF), regulates transcriptional initiation of protein-coding genes through direct binding to promoter elements and subsequent recruitment of other GTFs and RNA polymerase II. Although generally required for most protein-coding genes, accumulated studies have also demonstrated promoter-specific functions for several TFIID subunits in gene activation. Here, we report that TBP-associated factor 2 (TAF2) specifically regulates TFIID binding to a small subset of protein-coding genes and is essential for cell growth of multiple cancer lines. Co-immunoprecipitation assays revealed that TAF2 may be sub-stoichiometrically associated with the TFIID complex, thus indicating a minor fraction of TAF2-containing TFIID in cells. Consistently, integrated genome-wide profiles show that TAF2 binds to and regulates only a small subset of protein-coding genes. Furthermore, through the use of an inducible TAF2 degradation system, our results reveal a reduction of TBP/TFIID binding to several ribosomal genes upon selective ablation of TAF2. In addition, depletion of TAF2, as well as the TAF2-regulated ribosomal protein genes RPL30 and RPL39, decreases ribosome assembly and global protein translation. Collectively, this study suggests that TAF2 within the TFIID complex is of functional importance for TBP/TFIID binding to and expression of a small subset of protein-coding genes, thus establishing a previously unappreciated promoter-selective function for TAF2.