bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel, braided, self-expandable stent designed for the treatment of pulsatile tinnitus caused by intracranial venous stenosis: first-in-human experience and long-term outcomes
Authors: Consoli Arturo , Cancelliere Nicole M , Charbonnier Guillaume , Nishi Hidehisa , Vanek Irene , Marotta Thomas R , Spears Julian , Pereira Vitor M 
Published: May 2024

BackgroundPulsatile tinnitus (PT) can be a disabling clinical condition, which may be caused by a sigmoid/transverse sinus stenosis (STSS). Intracranial venous stenting with off-label carotid or peripheral venous stents has been used successfully to treat this condition. We present the results of a cohort of patients presenting with PT treated with a novel, dedicated, braided stent for the endovascular treatment of STSS.MethodsTwelve patients presenting with PT and associated STSS were treated at our institution (December 2022–June 2023). All clinical and procedural variables were prospectively collected. We used the Tinnitus Function Index (TFI) and the Tinnitus Handicap Inventory (THI) scores to assess the impact of PT on quality of life before and after the treatment (mean follow-up: 10.3 months).ResultsTwelve women (mean age: 44±16.5 years) presenting with PT and STSS were treated. Mean pretreatment TFI/THI scores were 78.8/77. The BosStent was successfully deployed in all patients. We experienced no intraprocedural/postoperative complications. Intra-stent angioplasty was performed in three cases. All patients reported a complete resolution of PT symptoms within 1 month and remained stable and PT-free at the last follow-up (mean posttreatment TFI/THI score: 7.1/5, p<0001).ConclusionsThe BosStent was successfully used in a cohort of patients with PT without any intraprocedural complications. All the patients experienced a complete resolution of PT symptoms after 1 month, which was stable during the follow-up period. Further studies with larger populations will be necessary to investigate the safety and effectiveness of this novel stent for the treatment of PT with STSS.
Association of blood pressure and outcomes differs upon cerebral perfusion post-thrombectomy in patients with acute ischemic stroke
Authors: Liu Jinjie , Nie Ximing , Zhang Zhe , Duan Wanying , Liu Xin , Yan Hongyi , Zheng Lina , Fang Changgeng , Chen Jiaping , Wang Yuyi , Wen Zhixuan , Cai Shuning , Wen Miao , Yang Zhonghua , Pan Yuesong , Liu Sibo , Liu Liping 
Published: May 2024

BackgroundThe relationship between post-endovascular thrombectomy (EVT) blood pressure (BP) and outcomes in patients with acute ischemic stroke (AIS) remains contentious. We aimed to explore whether this association differs with different cerebral perfusion statuses post-EVT.MethodsIn a multicenter observational study of patients with AIS with large vessel occlusion who underwent EVT, we enrolled those who accepted CT perfusion (CTP) imaging within 24 hours post-EVT. We recorded post-EVT systolic (SBP) and diastolic BP. Patients were stratified into favorable perfusion and unfavorable perfusion groups based on the hypoperfusion intensity ratio (HIR) on CTP. The primary outcome was good functional outcome (90-day modified Rankin Scale score of ≤3). Secondary outcomes included early neurological deterioration, infarct size growth, and symptomatic intracranial hemorrhage.ResultsOf the 415 patients studied (mean age 62 years, 75% male), 233 (56%) achieved good functional outcomes. Logistic regression showed that post-EVT HIR and 24-hour mean SBP were significantly associated with functional outcomes. Among the 326 (79%) patients with favorable perfusion, SBP <140 mmHg was associated with a higher percentage of good functional outcomes compared with SBP ≥140 mmHg (68% vs 52%; aOR 1.70 (95% CI 1.00 to 2.89), P=0.04). However, no significant difference was observed between SBP and functional outcomes in the unfavorable perfusion group. There was also no discernible difference between SBP and secondary outcomes across the different perfusion groups.ConclusionsIn patients with favorable perfusion post-EVT, SBP <140 mmHg was associated with good functional outcomes, which underscores the need for further investigations with larger sample sizes or a more individualized BP management strategy.Clinical trial registrationChiCTR1900022154.
Delta opioid peptide [D-ala2, D-leu5]-Enkephalin’s ability to enhance mitophagy via TRPV4 to relieve ischemia/reperfusion injury in brain microvascular endothelial cells
Authors: Deng Zhongfang , Chen Xiaoyu , Zhang Ran , Kong Lingchao , Fang Yang , Guo Jizheng , Shen Bing , Zhang Lesha 
Published: May 2024

BackgroundLocal brain tissue can suffer from ischaemia/reperfusion (I/R) injury, which lead to vascular endothelial damage. The peptide δ opioid receptor (δOR) agonist [D-ala2, D-leu5]-Enkephalin (DADLE) can reduce apoptosis caused by acute I/R injury in brain microvascular endothelial cells (BMECs).ObjectiveThis study aims to explore the mechanism by which DADLE enhances the level of mitophagy in BMECs by upregulating the expression of transient receptor potential vanilloid subtype 4 (TRPV4).MethodsBMECs were extracted and made to undergo oxygen-glucose deprivation/reoxygenation (OGD/R) accompanied by DADLE. RNA-seq analysis revealed that DADLE induced increased TRPV4 expression. The CCK-8 method was used to assess the cellular viability; quantitative PCR (qPCR) was used to determine the mRNA expression ofDrp1; western blot was used to determine the expression of TRPV4 and autophagy-related proteins; and calcium imaging was used to detect the calcium influx. Autophagosomes in in the cells’ mitochondria were observed by using transmission electron microscopy. ELISA was used to measure ATP content, and a JC-1 fluorescent probe was used to detect mitochondrial membrane potential.ResultsWhen compared with the OGD/R group, OGD/R+DADLE group showed significantly enhanced cellular viability; increased expression of TRPV4, Beclin-1, LC3-II/I, PINK1 and Parkin; decreased p62 expression; a marked rise in calcium influx; further increases in mitophagy, an increase in ATP synthesis and an elevation of mitochondrial membrane potential. These protective effects of DADLE can be blocked by a TRPV4 inhibitor HC067047 or RNAi of TRPV4.ConclusionDADLE can promote mitophagy in BMECs through TRPV4, improving mitochondrial function and relieving I/R injury.
Precision pest control using purpose-built uncrewed aerial system (UAS) technology and a novel bait pod system
Authors: Morley Craig G. , Solaris Philip , Quinn Greg O. , Ross Kathryn E. , Peterson Bruce J. 
Published: May 2024

Controlling invasive species is imperative due to their significant roles in spreading diseases, preying on threatened species, and diminishing biodiversity. Crewed aircraft are proficient at dispersing toxic bait across vast expanses to combat small pest mammals such as possums and rats. However, their utility diminishes significantly in small, remote areas typified by rugged terrain due to impracticality and prohibitive costs. Similarly, while ground control operations are effective in compact, easily reachable locations, they encounter formidable obstacles like costly labour expenses, safety hazards, and the peril of worker injuries while navigating treacherous landscapes. An innovative approach to address these limitations is to use uncrewed aerial systems that are unhampered by the terrain to deploy bait at precise locations. Our team engineered a purpose-built system designed specifically for deploying bait using innovative bait pods. Two field trials were conducted in New Zealand to validate our systems’ efficacy, assessing deployment precision and accuracy against predefined ground targets. While the initial trial yielded mixed results, significant improvements were observed in the subsequent trial, featuring enhancements to the bait pod design. The median deployment accuracy achieved was 1.91 m from the target ( n = 63), with no statistically significant difference in deployment accuracy between open and forested areas ( p = 0.76). This advanced system permits the precise placement of bait pods to any location, facilitating effective pest control within complex landscapes, challenging terrain, and dense vegetation. With its smart functionality and adaptability, this system can be utilised across various aircraft and autopilot systems to ensure maximum accuracy and efficiency in delivering bait pods for pest control operations. Therefore, this innovative tool possesses tremendous potential for managing small mammalian invasive species, particularly in specialised environments such as reserves, gullies, and islands, complementing existing pest control strategies to expedite the restoration of ecosystems and safeguard biodiversity.
Molecular dynamics exploration of the temperature-dependent elastic, mechanical, and anisotropic properties of hcp ruthenium
Authors: Güler E. , Uğur Ş. , Güler M. , Uğur G. 
Published: May 2024

AbstractMolecular dynamics calculations were performed for the hitherto unclarified temperature-dependent elastic, mechanical, and anisotropic properties of the hexagonal closed pack (hcp) ruthenium (Ru) between 0 and 1200 K. All elastic stiffness constants were found to decrease with increasing temperature. Under the examined temperature range, hcp Ru obeys Born stability conditions. Further, both Pugh ratio analyses and calculated Poisson ratio values mutually suggest the brittle character of hcp Ru between 0 and 1200 K. The intricate hardness behavior of hcp Ru was also obtained and discussed throughout the work. For the considered temperature range, hcp Ru exhibits apparent elastic anisotropy that exponentially increases with increasing temperature. Moreover, presently obtained ground state (T = 0 K and P = 0 GPa) theoretical data for hcp Ru agree well with the former experimental and theoretical data. The present findings on the temperature-dependent characteristics of this metal may further inspire future applied works.
Graphical abstract
Shape isomers: status and perspectives across the nuclear chart
Authors: Leoni S. , Fornal B. , Mărginean N. , Wilson J. N. 
Published: May 2024

AbstractThe paper reviews the searches for shape isomers, which are “extreme” example of shape-coexistence phenomena in nuclei. They may appear when highly deformed structures, well localized in the nuclear Potential Energy Surface (PES) in the deformation space, undergo a significant change in shape to match the final state shape, thus leading to a substantially hindered $$\gamma$$
γ
decay. This is in sharp contrast to the vast majority of shape-coexistence phenomena, where significant mixing in the initial and final state wave functions is found. So far, the most spectacular examples of shape isomerism are known in fissioning systems in the actinides, although only scarce experimental information is available from experiments conducted more than 20 years ago. Searches in lighter mass regions, guided by theory predictions based on different approaches and experimental investigations on superdeformed systems, are also presented. They point to $$^{64,66}$$

64
,
66

Ni as additional examples of prolate deformed shape-isomer-like structures, although with much reduced hindrance with respect to the actinides. Their origin is strictly related to the action of the monopole component of the tensor force of the nucleon-nucleon interaction, which is expected to favor the appearance of deep secondary minima also in the PES of Sn nuclei with masses 112–118. Perspectives in current searches of shape isomerism with modern detection systems, in the actinides regions and in lighter masses, are discussed.
The Proterozoic–Cambrian salt detachment zone at Lakhar Kuh, Iran: a seismic-scale analogue for salt stringers, detachment folding and multiphase structural development
Authors: Morley Christopher K. , Back Stefan 
Published: May 2024

Abstract
In the Middle East, significant evaporite units formed in the latest Precambrian–Cambrian, Triassic, Jurassic, Cretaceous and Cenozoic. The Precambrian–Cambrian period gave rise to the Ara Salt carbonate stringer plays, southern Oman and the giant Zagros anticline traps (Hormuz Formation). While outcrops of salt diapirs are common, basal detachment exposures are extremely rare. The Lakar Kuh area of Central Iran reveals the Precambrian–Cambrian basal salt detachment, on satellite images, in natural cross-section view through the entire Phanerozoic sedimentary section east of Ravar. This view illustrates how older diapiric structures (pillows and normal faults) were the focus of later contractional folds, particularly in the Jurassic and Cenozoic. The salt detachment zone contains many floating blocks (stringers) of clastic, carbonate and igneous rocks. Some blocks were stoped from the overlying beds, while most were layers originally interbedded with the evaporites. Block size, distribution and orientation is highly variable, and folding is infrequent. Lakar Kuh encompasses several key themes generally pertinent to structural geology and salt system research: the presence of sedimentary stringers within evaporites, multiple detachment levels within a thick (>5 km) stratigraphic section, detachment folding, multiphase salt activity, reactivation of older structures by newer ones and multi-stage development of salt bodies.
Abstract PO1-07-03: An Accurate Breast Cancer Diagnosis Method Using a Multi-Feature Fusion Neural Network on Contrast-Enhanced Spectral Mammography
Authors: Song Yipeng , Jiang Wei 
Published: May 2024

Abstract
Objectives: Our study aims to develop an accurate and comprehensive deep neural network capable of classifying CESM images to aid in the early detection and diagnosis of breast cancer in clinical settings. Methods: We enrolled diagnostic CESM examinations conducted between January 1, 2019 and January 17, 2021. We developed and tested the performance of a multi-feature fusion network for breast lesion classification by combining low-energy (LE) and dual-energy subtracted (DES) images, dual-view, and bilateral information using a large and diverse CESM dataset. We have evaluated the ability of the proposed network to generalize on external datasets and the results were reported using the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity. Results: In the study period 1973CESMs were included. Mean age was 53 years ± 12 (standard deviation). In the internal test dataset, the model with CESM (LE +DES) inputs combined not only bilateral information (left and right breasts) but also dualview information (CC and MLO), achieved best diagnosis performance with AUC of 0.96 [95% confidence interval (CI): 0.95–0.97], accuracy of 0.9 [95% confidence interval (CI): 0.88–0.92], sensitivity of 0.84 [95% confidence interval (CI): 0.80–0.88] and specificity of 0.93 [95% confidence interval (CI): 0.91–0.95], while the model with LE inputs only got an AUC of 0.94 [95% (CI): 0.93–0.95], accuracy of 0.88 [95% confidence interval (CI): 0.86–0.90], sensitivity of 0.79 [95% confidence interval (CI): 0.74–0.83] and specificity of 0.93 [95% confidence interval (CI): 0.91–0.95] (external dataset: an AUC of 0.90 [95% (CI): 0.85–0.94], accuracy of 0.84 [95% confidence interval (CI): 0.78–0.89], sensitivity of 0.77 [95% confidence interval (CI): 0.61–0.88] and specificity of 0.87 [95% confidence interval (CI):0.80–0.92]). Conclusion: CESM is a promising technique in breast cancer diagnosis due to its high feasibility and potential. The results demonstrate that left-right breast fusion and dual-view fusion are helpful for accurate diagnosis on CESM images. Specifically, dual-energy subtracted (DES) images generated by CESM improve diagnostic accuracy when compared to low-energy (LE) images alone. Keywords: Contrast-enhanced spectral mammography; Deep neural network; Breast cancer diagnosis; Multi-feature fusion
Citation Format: Yipeng Song, Wei Jiang. An Accurate Breast Cancer Diagnosis Method Using a Multi-Feature Fusion Neural Network on Contrast-Enhanced Spectral Mammography [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-07-03.
Abstract PO1-24-10: B cell–mediated immunity predicts survival of patients with ER-positive breast cancer
Authors: Lee Seungbok , Kang Byung-Hee , Lee Han-Byoel , Han Wonshik , Kim In Ah 
Published: May 2024

Abstract
Background: The estrogen receptor-positive (ER+) breast cancer (BC), which constitutes the majority of BC cases, exhibits highly heterogeneous clinical behavior. To aid precision treatments, we aimed to find molecular subtypes of ER+ BC representing the tumor microenvironment.
Methods: We analyzed RNA-seq data of 113 BC patients and classified them according to the PAM50 intrinsic subtypes using gene expression profiles. Among them, we further focused on 48 patients with luminal-type (ER+) BC for subclassification. The Cancer Genome Atlas (TCGA) data of BC patients were utilized as a validation dataset to verify the new classification.
Results: Principal component analysis clearly divided the patients into two subgroups separately from the luminal A and B classification. The top differentially expressed genes between the subgroups were distinctly characterized by immunoglobulin and B cell–related genes. We could also cluster a separate cohort of patients with luminal-type BC from TCGA into two subgroups based on the expression of a B cell–specific gene set, and patients with high B cell immune activity had better prognoses than other patients.
Conclusions: Our transcriptomic approach defines a novel molecular phenotype of B cell immunity in ER+ BC that may help to predict disease prognosis. Although further researches are required, B cell immunity for ER+ BC patients may be helpful for identifying patients who are good responder to chemotherapy or immunotherapy. Work supported by grants from the National Research Foundation of Korea (NRF-2023R1A2C3003782)
Citation Format: Seungbok Lee, Byung-Hee Kang, Han-Byoel Lee, Wonshik Han, In Ah Kim. B cell–mediated immunity predicts survival of patients with ER-positive breast cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO1-24-10.
Abstract PO2-03-03: The Significance of Cavity Shave Margins in Breast Carcinoma on Margin Status and Re-excision Rates
Authors: Zaiem Fadi , Numi Anna , Kheil Mira , AbuJamea Asem , Jain Deepti , Abbas Omar , Larson Lauren , Suleiman Noor , Al-Juburi Saleh , Awada Sanaa , Almsaddi Ragad , Jang Hyejeong , Kim Seongho , Salem Nagla , Choi Lydia , Bandyopadhyay Sudeshna , Jaiman Sunil , Ali-Fehmi Rouba 
Published: May 2024

Abstract
Context: The comparative outcomes of breast conserving surgery (BCS) with and without cavity shave margins are not well established. We aim to evaluate the impact of each procedure on final margin status and rate of re-excision.
Design: A total of 529 breast cancer cases from our institution between 2013-2015 were included. Demographic and clinicopathological data including procedure type, tumor type, grade, margins status, and re-excision rates were collected. H&E slides of positive margins (tumor on ink) were reviewed by two pathologists. Appropriate statistical analysis was performed.
Results: Out of 529 breast cancer cases, 125 were Ductal Carcinoma in situ (DCIS), 152 were Invasive Ductal Carcinoma (IDC) and 252 had both pathologies. The median age of patients was 59 years (range: 24-90). Patients who underwent excision with shave margins were 162 (35 DCIS, 56 IDC, 71 both) while excision without shave margins were 367 (90 DCIS, 96 IDC, 181 both). Re-excision rates were significantly lower 1) in patients who underwent BCS with cavity shave margins compared to those without (OR 0.32, p&lt; 0.001) and 2) in patients who did not require lymph node excision compared to those who did (OR 4.26, p&lt; 0.001). Additionally, patients who had DCIS had a higher rate of re-excision than those with invasive cancer only (OR 5.17, P&lt; .001). After adjusting for type of tumor, patients who underwent cavity shaving compared to those who did not, no significant difference was seen in tumor at margins (OR 0.73, p=0.282) or tumor within 2mm (OR 1.14, p=0.512) from margins. However, patients with IDC who underwent cavity shave had a higher proportion of negative tumor at the margins (76.5% vs. 67.0%; p=0.051). We found that patients who had an invasive carcinoma (IC) had a lower risk of having tumor at the margin or within 2 mm from the margin than those with DCIS or DCIS+IC, (p&lt; .05).
Conclusions: Our data shows that BCS with cavity shave margins is superior with regards to negative margin and re-excision rates when compared to without cavity shave margins.
Citation Format: Fadi Zaiem, Anna Numi, Mira Kheil, Asem AbuJamea, Deepti Jain, Omar Abbas, Lauren Larson, Noor Suleiman, Saleh Al-Juburi, Sanaa Awada, Ragad Almsaddi, Hyejeong Jang, Seongho Kim, Nagla Salem, Lydia Choi, Sudeshna Bandyopadhyay, Sunil Jaiman, Rouba Ali-Fehmi. The Significance of Cavity Shave Margins in Breast Carcinoma on Margin Status and Re-excision Rates [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-03-03.