bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oversight Hearings, Stakeholder Engagement, and Compliance in the Inter-American Court of Human Rights
Authors: Pérez-Liñán Aníbal , García Atehortúa Angie K. 
Published: May 2024

AbstractThis paper introduces the concept of dialogic oversight, a process by which judicial bodies monitor compliance through a combination of mandated state reporting, third-party engagement, and supervision hearings. To assess the effectiveness of this strategy in the international arena, we evaluate the supervision hearings conducted by the Inter-American Court of Human Rights. We employ propensity-score matching, difference-in-difference estimators, and event-history models to analyze compliance with 1,878 reparation measures ordered by the Court between 1989 and 2019. We find that dialogic oversight has moderate but positive effects, increasing the probability of state compliance by about 3 percent per year (a substantial effect compared to the baseline rate of implementation). However, it requires the engagement of civil society to yield positive outcomes. Our framework connects related findings in distant literatures on constitutional law and international organizations.
Reductionism and proxy failure: From neuroscience to target-based drug discovery
Authors: Sadri Arash , Paknezhad Sepideh 
Published: May 2024

Abstract
Reductionist methodologies reduce phenomena to some of their lower-level components. Researchers gradually shift their focus away from observing the actual object of study toward investigating and optimizing such lower-level proxies. Following reductionism, these proxies progressively diverge further from the original object of study. We vividly illustrate this in the evolution of target-based drug discovery from rational and phenotypic drug discovery.
Navigating a Hostile Medium: Observations of the Environment As an Aid to Oceanic Voyaging in the Age of Sail
Authors: Wilkinson Clive 
Published: May 2024

AbstractEuropean navigation in the age of sail owes much to the scientific revolution of the seventeenth century and the development of instruments and advanced mathematical techniques. Important though these developments were, it is argued here that close observation of the environment: of the weather, ocean currents, clouds, birds, mammals, and a host of other factors played a far more important role in safe navigation from one part of the globe to another.
Truncus arteriosus from prenatal diagnosis to clinical outcome: a single-centre experience
Authors: Korsuize Nina A. , Bakhuis Wouter , van Wijk Bram , Grotenhuis Heynric B. , ter Heide Henriëtte , Cohen de Lara Michelle , Fejzic Zina , Schoof Paul H. , Haas Felix , Steenhuis Trinette J. 
Published: May 2024

AbstractBackground:The aim of this study was to review our institution’s experience with truncus arteriosus from prenatal diagnosis to clinical outcome.Methods:and results: We conducted a single-centre retrospective cohort study for the years 2005–2020. Truncus arteriosus antenatal echocardiographic diagnostic accuracy within our institution was 92.3%. After antenatal diagnosis, five parents (31%) decided to terminate the pregnancy. After inclusion from referring hospitals, 16 patients were offered surgery and were available for follow-up. Right ventricle-to-pulmonary artery continuity was preferably established without the use of a valve (direct connection), which was possible in 14 patients (88%). There was no early or late mortality. Reinterventions were performed in half of the patients at latest follow-up (median follow-up of 5.4 years). At a median age of 5.5 years, 13 out of 14 patients were still without right ventricle-to-pulmonary artery valve, which was well tolerated without signs of right heart failure. The right ventricle demonstrated preserved systolic function as expressed by tricuspid annular plane systolic excursion z-score (−1.4 ± 1.7) and fractional area change (44 ± 12%). The dimensions and function of the left ventricle were normal at latest follow-up (ejection fraction 64.4 ± 6.2%, fractional shortening 34.3 ± 4.3%).Conclusions:This study demonstrates good prenatal diagnostic accuracy of truncus arteriosus. There was no mortality and favourable clinical outcomes at mid-term follow-up, with little interventions on the right ventricle-to-pulmonary artery connection and no right ventricle deterioration. This supports the notion that current perspectives of patients with truncus arteriosus are good, in contrast to the poor historic outcome series. This insight can be used in counselling and surgical decision-making.
Human milk, breastfeeding, and early neurodevelopmental outcomes for infants with critical CHD
Authors: Elgersma Kristin M. , Engel Melissa L. , Ramel Sara E. , Davis Jessica A. , McKechnie Anne C. , Pfister Katie M. 
Published: May 2024

AbstractHuman milk improves neurodevelopment for preterm infants, but relationships between human milk and neurodevelopment for infants with critical CHD are unknown. We aimed to (1) explore associations between human milk/direct breastfeeding and neurodevelopment at 1-year and 2-year follow-up and (2) describe patterns of human milk (maternal, donor) and commercial formula during hospitalisation in the first year of life.This retrospective cohort study included infants who underwent surgery for CHD < 6 months old. The primary outcome was neurodevelopment via Bayley Scales of Infant Development-IV. Analysis included adjusted linear regression for associations between exclusive human milk while inpatient during the first 6 months or any direct breastfeeding while inpatient during the first year of life and 1-year Bayley-IV scores. Models were adjusted for race, insurance type, genetic diagnosis, and length of stay.Of 98 eligible infants, 40% followed up at 1 year; 27% at 2 years. There were differences in follow-up related to demographics (race, ethnicity) and social determinants of health (insurance type, distance from clinic). In adjusted models, infants who directly breastfed had 13.18 points higher cognition (95% CI: 0.84–25.53, p = 0.037); 14.04 points higher language (2.55–25.53, p = 0.018); and 15.80 points higher motor scores (3.27–28.34, p = 0.015) at 1-year follow-up. Infants fed exclusive human milk had 12.64 points higher cognition scores (−0.53–25.82, p = 0.059).Future investigation into nutrition and neurodevelopment in the context of critical CHD is warranted. As neurodevelopmental follow-up becomes standard of care in this population, efforts are needed to mitigate disparities in access to this care.
Misunderstanding and Meaning Change
Authors: Hines Andrew 
Published: May 2024

AbstractToday, the tone of discussion in the public sphere is dominated by misunderstanding. A common assumption is that misunderstanding comes from a failure of understanding. This article argues that misunderstanding is in fact a type of meaning change. To fully understand the contrast between misunderstanding as a failure of understanding and misunderstanding as a type of meaning change, the article uses Ludwig Wittgenstein and Hans-Georg Gadamer as a starting point to tease out an unthought assumption. Both thinkers challenge traditional preconceptions of how language shapes understanding and they make prominent use of the concept of misunderstanding to do so. Yet both rely on a de facto model of misunderstanding as a failure of understanding. To consider an alternative notion of misunderstanding, the article looks at examples from thinkers influenced by Wittgenstein's and Gadamer's philosophy. Finally, the article concludes by positing a new definition of misunderstanding.
Succession of the fungal community of a spacecraft assembly clean room when enriched in brines relevant to Mars
Authors: Carte Meris E. , Chen Fei , Clark Benton C. , Schneegurt Mark A. 
Published: May 2024

Abstract
Spacecraft can carry microbial contaminants from spacecraft assembly facilities (SAFs) to the cold arid surface of Mars that may confound life detection missions or disrupt native ecosystems. Dry hygroscopic sulphate and (per)chlorate salts on Mars may absorb atmospheric humidity and deliquesce at certain times to produce dense brines, potential sources of liquid water. Microbial growth is generally prohibited under the non-permissive condition of extremely low water activity in the frigid potential brines on Mars. Here we challenged the microbial community from samples of the Jet Propulsion Laboratory SAF with the extreme chemical conditions of brines relevant to Mars. Enrichment cultures in SP medium supplemented with 50% MgSO4 or 20% NaClO3 were inoculated from washes of SAF floor wipes. Samples were taken for each of the first four weeks and then at six months after inoculation to follow changes in the SAF microbial community under high salinity for long periods. Metagenomic DNA extracts of community samples were examined by Illumina sequencing of 18S rRNA gene sequences using fungal primers. The fungal assemblage during the first month of enrichment was predominantly common Ascomycetes, primarily Saccharomyete yeasts. Basidiomycetes were detected, mainly in the Microbotryomycetes and Tremellomycetes. Fungi were much less abundant in enrichment cultures at 50% MgSO4 than at 20% NaClO3. After 6 months of enrichment, few fungi remained. Microbes persisting from the JPL SAF microbial community in aged cultures enriched at extreme salinities might be the most capable of subsequently surviving and proliferating at the near surface of Mars. The SAF fungal assemblage did not survive and proliferate as well as the SAF bacterial community.
In-vitro induced drought and heat stress on seed germination of diverse African sorghum germplasm
Authors: Ndlovu Elton , Maphosa Mcebisi , Van Staden Johannes 
Published: May 2024

AbstractOne of the critical growth and development stages that is vulnerable to drought and heat stress even in hardy staple crops is germination. Sorghum is a critically essential, resilient, and diverse crop that displays genotypic variations in its ability to withstand such harsh conditions, limiting crop stand and ultimately leading to yield losses. Therefore, the goal of this study was to evaluate the performance of 50 high potential genotypes of African sorghum, including landraces, breeding lines and check varieties to simulated drought and heat stress at germination stage. The study used a split plot arrangement for temperature treatments, laid in a completely randomized design with three replications. Final germination percentage, mean germination time, germination index and coefficient variation of germination time (CVt) were determined. Data was subjected to generalized linear model, principal component analysis, hierarchical agglomerative cluster analysis and principal coordinate analysis to determine statistical differences in genotypes and visualize groups of genotypes according to their overall performance in assessed germination parameters. Drought stress and supra-optimal temperatures suppressed and delayed germination. The genotypes were grouped into six distinct clusters based on their performance. Genotypes NPGRC1593, NPGRC1782, NPGRC1476 and IS224426 performed exceptionally well under both stressors and outperformed check varieties in almost all parameters assessed. To improve crop establishment and increase agricultural yields, breeding and crop improvement programs should focus on genotypes that can withstand both stresses.
Royalty, Racism, and Risk
Authors: Barnes Sandra L. 
Published: May 2024

Abstract
W. E. B. Du Bois provides a thesis on Black masculinity formation that includes primary traits of this social identity and dynamics that can engender or stymie its development. Yet his framework does not directly reference sexual minorities. This study considers whether and how Du Bois’s framework on masculinity is germane to the experiences of young Black people with diverse sexual identities by assessing whether they recount similar tropes and features. The analysis is theoretically informed by a New Millennium Du Boisian Mode of Inquiry and a qualitative analysis for 168 young Black persons who reside in the South. Three themes emerge that adopt, amplify, and adapt dimensions of Du Bois’s thesis and demonstrate that key aspects of his framework resonate with Black persons excluded from his original work. Despite nuanced sexual identities, it was common for individuals to espouse Du Bosian tenets associated with Black masculinity such as a protector/provider trope, respectability, racial pride, educational attainment, economic mobility, and self-help as well as concerns about racism. These findings inform research on expectations about masculinity into which many men are generally socialized as well as possible hierarchies among intersecting social identities.
Foreshadowing Du Bois
Authors: Harris Kelly 
Published: May 2024

AbstractW. E. B. Du Bois is widely regarded as the foundational Black social scientist in the United States. He lived during a historical period when social science was predominantly considered the creation and domain of White scholars. In primary sociology texts, Du Bois is typically mentioned in passing, often as the sole Black social scientist acknowledged in social science historiography. At the other end of the spectrum, many Black social scientists today begin their exploration with Du Bois, recognizing his brilliant and groundbreaking contributions. However, both of these approaches seemingly imply that there were no notable Black social scientists before Du Bois. This paper aims to challenge that assumption by examining early nineteenth-century Black social science through the lens of James McCune Smith. Despite being a close friend to prominent figures like Frederick Douglass, Gerrit Smith, John Brown, and Alexander Crummell, McCune Smith has been relegated to a historical footnote in most accounts, except in a few recent notable works.
Modeling Lobe‐And‐Cleft Instabilities on a River Plume
Authors: Shi Fengyan , Simpson Alexandra , Hsu Tian‐Jian 
Published: May 2024

AbstractThe lobe‐and‐cleft instability is a widely recognized mechanism leading to along‐front structure on density current fronts. Early studies based on laboratory and numerical simulations suggested that the lobe‐and‐cleft instability is due to convective instability in the nose of gravity currents traveling over a nonslip boundary. Horner‐Devine and Chickadel (2017, https://doi.org/10.1002/2017gl072997) reported the presence of lobe‐and‐cleft instabilities at the Merrimack River, which are generated at the river front in the absence of a no‐slip boundary. Hence, the observed lobe‐and‐cleft instabilities must be due to other mechanisms. In this study, we carried out non‐hydrostatic large eddy simulations of a riverine outflow into an idealized 3D domain. With a fine grid resolution of 0.15 × 0.31 m in two horizontal directions and about 0.125 m in the vertical direction, the model reproduced the lobe‐and‐cleft feature, with the magnitude and size of lobes consistent with the field observation. The model results revealed that instabilities start from the primary Kelvin‐Helmholtz instability, followed by the secondary instability through stretching and tilting, generating counter‐rotating streamwise vortices in the plume and at the plume head. The upwelling associated with streamwise vortex cells brings a slower flow to the plume surface, resulting in lobe‐and‐cleft patterns at the front and positive and negative vertical vorticity at the plume surface. The model also predicted a lobe width of about two to three times the plume thickness, consistent with the field observation and the lobe/cleft spacing associated with pairs of counter‐rotating streamwise vortices. Modeled turbulent dissipation rate shows a trend of exponential decay from 10−4 to 10−3 m2/s3 at the frontal head to 10−7 to 10−6 m2/s3 behind the front, similar to the findings in the previous field studies.
Adenosine mediates the amelioration of social novelty deficits during rhythmic light treatment of 16p11.2 deletion female mice
Authors: Ju Jun , Li Xuanyi , Pan Yifan , Du Jun , Yang Xinyi , Men Siqi , Liu Bo , Zhang Zhenyu , Zhong Haolin , Mai Jinyuan , Wang Yizheng , Hou Sheng-Tao 
Published: May 2024

AbstractNon-invasive brain stimulation therapy for autism spectrum disorder (ASD) has shown beneficial effects. Recently, we and others demonstrated that visual sensory stimulation using rhythmic 40 Hz light flicker effectively improved cognitive deficits in mouse models of Alzheimer’s disease and stroke. However, whether rhythmic visual 40 Hz light flicker stimulation can ameliorate behavioral deficits in ASD remains unknown. Here, we show that 16p11.2 deletion female mice exhibit a strong social novelty deficit, which was ameliorated by treatment with a long-term 40 Hz light stimulation. The elevated power of local-field potential (LFP) in the prefrontal cortex (PFC) of 16p11.2 deletion female mice was also effectively reduced by 40 Hz light treatment. Importantly, the 40 Hz light flicker reversed the excessive excitatory neurotransmission of PFC pyramidal neurons without altering the firing rate and the number of resident PFC neurons. Mechanistically, 40 Hz light flicker evoked adenosine release in the PFC to modulate excessive excitatory neurotransmission of 16p11.2 deletion female mice. Elevated adenosine functioned through its cognate A1 receptor (A1R) to suppress excessive excitatory neurotransmission and to alleviate social novelty deficits. Indeed, either blocking the A1R using a specific antagonist DPCPX or knocking down the A1R in the PFC using a shRNA completely ablated the beneficial effects of 40 Hz light flicker. Thus, this study identified adenosine as a novel neurochemical mediator for ameliorating social novelty deficit by reducing excitatory neurotransmission during 40 Hz light flicker treatment. The 40 Hz light stimulation warrants further development as a non-invasive ASD therapeutics.
Oxidative photocatalysis on membranes triggers non-canonical pyroptosis
Authors: Lee Chaiheon , Park Mingyu , Wijesinghe W. C. Bhashini , Na Seungjin , Lee Chae Gyu , Hwang Eunhye , Yoon Gwangsu , Lee Jeong Kyeong , Roh Deok-Ho , Kwon Yoon Hee , Yang Jihyeon , Hughes Sebastian A. , Vince James E. , Seo Jeong Kon , Min Duyoung , Kwon Tae-Hyuk 
Published: May 2024

AbstractIntracellular membranes composing organelles of eukaryotes include membrane proteins playing crucial roles in physiological functions. However, a comprehensive understanding of the cellular responses triggered by intracellular membrane-focused oxidative stress remains elusive. Herein, we report an amphiphilic photocatalyst localised in intracellular membranes to damage membrane proteins oxidatively, resulting in non-canonical pyroptosis. Our developed photocatalysis generates hydroxyl radicals and hydrogen peroxides via water oxidation, which is accelerated under hypoxia. Single-molecule magnetic tweezers reveal that photocatalysis-induced oxidation markedly destabilised membrane protein folding. In cell environment, label-free quantification reveals that oxidative damage occurs primarily in membrane proteins related to protein quality control, thereby aggravating mitochondrial and endoplasmic reticulum stress and inducing lytic cell death. Notably, the photocatalysis activates non-canonical inflammasome caspases, resulting in gasdermin D cleavage to its pore-forming fragment and subsequent pyroptosis. These findings suggest that the oxidation of intracellular membrane proteins triggers non-canonical pyroptosis.
Mechanically controlled multifaceted dynamic transformations in twisted organic crystal waveguides
Authors: Rohullah Mehdi , Pradeep Vuppu Vinay , Singh Shruti , Chandrasekar Rajadurai 
Published: May 2024

AbstractThis study introduces mechanically induced phenomena such as standing, leaning, stacking, and interlocking behaviors in naturally twisted optical waveguiding microcrystals on a substrate. The microscale twisted crystal self-assembled from 2,4-dibromo-6-(((2-bromo-5-fluorophenyl)imino)methyl)phenol is flexible and emits orange fluorescence. Mechanistic analysis reveals the strain generated by the intergrowing orientationally mismatched nanocrystallites is responsible for the twisted crystal growth. The crystal’s mechanical flexibility in the perpendicular direction to (001) and (010) planes can be attributed to intermolecular Br···Br, F···Br, and π···π stacking interactions. Through a systematic process involving step-by-step bending and subsequent optical waveguiding experiments at each bent position, a linear relationship between optical loss and mechanical strain is established. Additionally, the vertical standing and leaning of these crystals at different angles on a flat surface and the vertical stacking of multiple crystals reveal the three-dimensional aspects of organic crystal waveguides, introducing light trajectories in a 3D space. Furthermore, the integration of two axially interlocked twisted crystals enables the coupling of polarization rotation along their long axis. These crystal dynamics expand the horizons of crystal behavior and have the potential to revolutionize various applications, rendering these crystals invaluable in the realm of crystal-related science and technology.
Targeting bacterial nickel transport with aspergillomarasmine A suppresses virulence-associated Ni-dependent enzymes
Authors: Sychantha David , Chen Xuefei , Koteva Kalinka , Prehna Gerd , Wright Gerard D. 
Published: May 2024

AbstractMicrobial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and persistence. Many microbes produce metallophores to sequester metals necessary for their metabolism and starve competing neighboring organisms. The fungal metallophore aspergillomarasmine A (AMA) shows narrow specificity for Zn2+, Ni2+, and Co2+. Here, we show that this specificity allows AMA to block the uptake of Ni2+ and attenuate bacterial Ni-dependent enzymes, offering a potential strategy for reducing virulence. Bacterial exposure to AMA perturbs H2 metabolism, ureolysis, struvite crystallization, and biofilm formation and shows efficacy in a Galleria mellonella animal infection model. The inhibition of Ni-dependent enzymes was aided by Zn2+, which complexes with AMA and competes with the native nickelophore for the uptake of Ni2+. Biochemical analyses demonstrated high-affinity binding of AMA-metal complexes to NikA, the periplasmic substrate-binding protein of the Ni2+ uptake system. Structural examination of NikA in complex with Ni-AMA revealed that the coordination geometry of Ni-AMA mimics the native ligand, Ni-(l-His)2, providing a structural basis for binding AMA-metal complexes. Structure-activity relationship studies of AMA identified regions of the molecule that improve NikA affinity and offer potential routes for further developing this compound as an anti-virulence agent.