bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency regulation in solar PV-powered thermal power system using FPA-PID controller through UPFC and RFB
Authors: Masikana S. B. , Sharma Gulshan , Sharma Sachin , Çelik Emre 
Published: May 2024

AbstractThe integration of additional renewable energy sources, such as solar PV, into the current power grid is a global priority due to the depletion of traditional supplies and rising power demand. In order to achieve load frequency control (LFC) of the power system with integration of solar PV, this study employs the construction of a proportional integral derivative (PID) scheme that has been fine-tuned via the flower pollination algorithm (FPA). When evaluating the performance of FPA-PID on an interconnected thermal power system, three distinct error values—integral time absolute error (ITAE), integral time multiplied by square error (ITSE), and integral of absolute error (IAE)—are taken into consideration. The results are compared with those of genetic algorithm, particle swarm optimization, and hybrid bacteria foraging optimization based PID. It can be observed that the error values achieved with FPA-PID are substantially lower than those obtained with other PID designs, which are ITSE of 2.07e−05, ITAE of 0.01839, and IAE of 0.008889. Furthermore, the PV integration has further decreased the ITSE to 7.872e−06, the ITAE to 0.008953, and the IAE to 0.005376. All error levels have been further reduced because of the integration of unified power flow control (UPFC) in series with the tie-line and redox flow battery (RFB) separately, utilizing the FPA-PID scheme with solar PV. Finally, it is seen that FPA-PID with solar PV and with UPFC outperforms other LFC designs. The graphical LFC plots verify that FPA-PID with solar PV and with UPFC has capability to reduce the frequency, tie-line power, and area control error excursions in comparison to other LFC designs.
Investigation of parenteral nutrition-induced hepatotoxicity using human liver spheroid co-cultures
Authors: Mihajlovic Milos , De Boever Sybren , Tabernilla Andrés , Callewaert Ellen , Sanz-Serrano Julen , Verhoeven Anouk , Maerten Amy , Rosseel Zenzi , De Waele Elisabeth , Vinken Mathieu 
Published: May 2024

AbstractParenteral nutrition (PN) is typically administered to individuals with gastrointestinal dysfunction, a contraindication for enteral feeding, and a need for nutritional therapy. When PN is the only energy source in patients, it is defined as total parenteral nutrition (TPN). TPN is a life-saving approach for different patient populations, both in infants and adults. However, despite numerous benefits, TPN can cause adverse effects, including metabolic disorders and liver injury. TPN-associated liver injury, known as intestinal failure-associated liver disease (IFALD), represents a significant problem affecting up to 90% of individuals receiving TPN. IFALD pathogenesis is complex, depending on the TPN components as well as on the patient’s medical conditions. Despite numerous animal studies and clinical observations, the molecular mechanisms driving IFALD remain largely unknown. The present study was set up to elucidate the mechanisms underlying IFALD. For this purpose, human liver spheroid co-cultures were treated with a TPN mixture, followed by RNA sequencing analysis. Subsequently, following exposure to TPN and its single nutritional components, several key events of liver injury, including mitochondrial dysfunction, endoplasmic reticulum stress, oxidative stress, apoptosis, and lipid accumulation (steatosis), were studied using various techniques. It was found that prolonged exposure to TPN substantially changes the transcriptome profile of liver spheroids and affects multiple metabolic and signaling pathways contributing to liver injury. Moreover, TPN and its main components, especially lipid emulsion, induce changes in all key events measured and trigger steatosis.
Radiologic and histopathologic effects of favipiravir and hydroxychloroquine on fracture healing in rats
Authors: Tekçe Giray , Arıcan Mehmet , Karaduman Zekeriya Okan , Turhan Yalcın , Sağlam Sönmez , Yücel Mücahid Osman , Coşkun Sinem Kantarcıoğlu , Tuncer Cengiz , Uludağ Veysel 
Published: May 2024

AbstractFracture healing is a process in which many factors interact. In addition to many treatments, physical and biological therapy methods that affect different steps of this process, there are many biological and chemical agents that cause fracture union delay. Although the number of studies on fracture healing is increasing day by day, the mechanism of fracture healing, which is not fully understood, still attracts the attention of all researchers. In this study, we aimed to investigate the effects of favipiravir and hydroxychloroquine used in the treatment of COVID-19. In this study, 48 male Wistar rats weighing 300 ± 50 g were used. Each group was divided into eight subgroups of six rats each to be sacrificed at the 2nd and 4th weeks and evaluated radiologically and histologically. Favipiravir (group 1), hydroxychloroquine (group 2), favipiravir + hydroxychloroquine (group 3), and random control (group 4) were used. A statistically significant difference was observed between the 15th day histological scoring averages of the groups (p < 0.05). Although there was no statistically significant difference between the 15th day radiological score distributions of the groups (p > 0.05), we obtained different results in terms of complete bone union distributions and radiological images of the fracture line. Although favipiravir has a negative effect on fracture union in the early period, favipiravir may have a positive effect on fracture union in the late period. We did not find any effect of hydroxychloroquine on fracture union.
Behavior, site use and demographics of shortfin devil rays, Mobula kuhlii, at a newly-discovered cleaning area in South Africa
Authors: Carpenter M. M. , Perryman R. J. Y. , Marshall A. D. , Griffiths C. L. 
Published: May 2024

AbstractMany shark and ray species show affinity to specific sites, making these areas critical for their survival. These include cleaning stations: locations on reefs where cleaner fish remove parasites and clean wounds, which is important for maintaining health. Cleaning stations also function as social gathering sites, or resting points, where courtship and mating can occur. In this study, we identify an aggregation site for the shortfin devil ray, Mobula kuhlii (Family Mobulidae) within the Aliwal Shoal Marine Protected Area in KwaZulu-Natal (KZN), South Africa, and document their behavior. Remote underwater video was used to collect footage of M. kuhlii being cleaned by blue streak cleaner wrasse, Labroides dimidiatus. Generalized additive models (GAMs) were used to assess environmental predictors of M. kuhlii presence on Aliwal Shoal. Mixed models were used to assess the same environmental predictors and their correlation with mean M. kuhlii cleaning duration and number of L. dimidiatus bites per second at the identified cleaning station site. M. kuhlii were present in 56% of observation days, with group numbers up to > 150 individuals. Sea surface temperature was a significant predictor for M. kuhlii presence, while a north to south current was significantly associated with longer mean cleaning durations. These results support findings of mobulid studies in KZN that show increased habitat use during summer temperatures (24–25 °C) and suggest these sites to be important for individual health and social interaction. We hope these findings can be used for development of location-specific management plans to safeguard this Endangered species.
Evaluation of the antitumor effect of neoantigen peptide vaccines derived from the translatome of lung cancer
Authors: Lian Fenbao , Yang Haitao , Hong Rujun , Xu Hang , Yu Tingting , Sun Gang , Zheng Guanying , Xie Baosong 
Published: May 2024

AbstractEmerging evidence suggests that tumor-specific neoantigens are ideal targets for cancer immunotherapy. However, how to predict tumor neoantigens based on translatome data remains obscure. Through the extraction of ribosome-nascent chain complexes (RNCs) from LLC cells, followed by RNC-mRNA extraction, RNC-mRNA sequencing, and comprehensive bioinformatic analysis, we successfully identified proteins undergoing translatome and exhibiting mutations in the cells. Subsequently, novel antigens identification was analyzed by the interaction between their high affinity and the Major Histocompatibility Complex (MHC). Neoantigens immunogenicity was analyzed by enzyme-linked immunospot assay (ELISpot). Finally, in vivo experiments in mice were conducted to evaluate the antitumor effects of translatome-derived neoantigen peptides on lung cancer. The results showed that ten neoantigen peptides were identified and synthesized by translatome data from LLC cells; 8 out of the 10 neoantigens had strong immunogenicity. The neoantigen peptide vaccine group exhibited significant tumor growth inhibition effect. In conclusion, neoantigen peptide vaccine derived from the translatome of lung cancer exhibited significant tumor growth inhibition effect.
Codonopsis pilosula-derived glycopeptide dCP1 promotes the polarization of tumor-associated macrophage from M2-like to M1 phenotype
Authors: Liu Hongxu , Yao Maojin , Ren Jiaoyan 
Published: May 2024

AbstractThe majority of the immune cell population in the tumor microenvironment (TME) consists of tumor-associated macrophages (TAM), which are the main players in coordinating tumor-associated inflammation. TAM has a high plasticity and is divided into two main phenotypes, pro-inflammatory M1 type and anti-inflammatory M2 type, with tumor-suppressive and tumor-promoting functions, respectively. Considering the beneficial effects of M1 macrophages for anti-tumor and the high plasticity of macrophages, the conversion of M2 TAM to M1 TAM is feasible and positive for tumor treatment. This study sought to evaluate whether the glycopeptide derived from simulated digested Codonopsis pilosula extracts could regulate the polarization of M2-like TAM toward the M1 phenotype and the potential regulatory mechanisms. The results showed that after glycopeptide dCP1 treatment, the mRNA relative expression levels of some M2 phenotype marker genes in M2-like TAM in simulated TME were reduced, and the relative expression levels of M1 phenotype marker genes and inflammatory factor genes were increased. Analysis of RNA-Seq of M2-like TAM after glycopeptide dCP1 intervention showed that the gene sets such as glycolysis, which is associated with macrophage polarization in the M1 phenotype, were significantly up-regulated, whereas those of gene sets such as IL-6-JAK-STAT3 pathway, which is associated with polarization in the M2 phenotype, were significantly down-regulated. Moreover, PCA analysis and Pearson's correlation also indicated that M2-like TAM polarized toward the M1 phenotype at the transcriptional level after treatment with the glycopeptide dCP1. Lipid metabolomics was used to further explore the efficacy of the glycopeptide dCP1 in regulating the polarization of M2-like TAM to the M1 phenotype. It was found that the lipid metabolite profiles in dCP1-treated M2-like TAM showed M1 phenotype macrophage lipid metabolism profiles compared with blank M2-like TAM. Analysis of the key differential lipid metabolites revealed that the interconversion between phosphatidylcholine (PC) and diacylglycerol (DG) metabolites may be the central reaction of the glycopeptide dCP1 in regulating the conversion of M2-like TAM to the M1 phenotype. The above results suggest that the glycopeptide dCP1 has the efficacy to regulate the polarization of M2-like TAM to M1 phenotype in simulated TME.
Asymptotic Analysis for the Generalized Langevin Equation with Singular Potentials
Authors: Duong Manh Hong , Nguyen Hung Dang 
Published: May 2024

AbstractWe consider a system of interacting particles governed by the generalized Langevin equation (GLE) in the presence of external confining potentials, singular repulsive forces, as well as memory kernels. Using a Mori–Zwanzig approach, we represent the system by a class of Markovian dynamics. Under a general set of conditions on the nonlinearities, we study the large-time asymptotics of the multi-particle Markovian GLEs. We show that the system is always exponentially attractive toward the unique invariant Gibbs probability measure. The proof relies on a novel construction of Lyapunov functions. We then establish the validity of the small-mass approximation for the solutions by an appropriate equation on any finite-time window. Important examples of singular potentials in our results include the Lennard–Jones and Coulomb functions.
Endoscopic intervention versus radical nephroureterectomy for the management of localized upper urinary tract urothelial carcinoma: a systematic review and meta-analysis of comparative studies
Authors: Giulioni Carlo , Brocca Carlo , Tramanzoli Pietro , Stramucci Silvia , Mantovan Matteo , Perpepaj Leonard , Cicconofri Andrea , Gauhar Vineet , Merseburger Axel Stuart , Galosi Andrea Benedetto , Castellani Daniele 
Published: May 2024

Abstract
Objective
Localized Upper Urinary Tract Urothelial Carcinoma (UTUC) is an uncommon cancer typically detected at an advanced stage. Currently, radical nephroureterectomy (RNU) with bladder cuff excision is the standard treatment for high-risk UTUC. This meta-analysis aims to evaluate the 5-year overall and cancer-specific survival and bladder recurrence rates in studies comparing endoscopic kidney-sparing surgeries (E-KSS) with RNU in localized UTUC.

Evidence acquisition
We performed a literature search on 20th April 2023 through PubMed, Web of Science, and Scopus. The PICOS model was used for study inclusion: P: adult patients with localized UTUC; I: E-KSS. C: RNU; O: primary: overall survival (OS); secondary: cancer-specific survival (CSS), bladder recurrence rate, and metastasis-free survival (MFS). S: retrospective, prospective, and randomized studies.

Evidence synthesis
Overall, 11 studies involving 2284 patients were eligible for this meta-analysis, 737 in the E-KSS group and 1547 in the RNU group. E-KSS showed a similar overall 5-year OS between E-KSS and RNU, and for low-grade tumors, while 5-year OS favored RNU for high-grade tumors (RR 1.84, 95% CI 1.26–2.69, p = 0.002). No difference emerged for 5-year CSS between the two groups, even when the results were stratified for low- and high grade tumors. Bladder recurrence rate and 5-year MFS were also similar between the two groups.

Conclusions
Our review showed that E-KSS is a viable option for patients with localized UTUC with non-inferior oncological outcomes as compared with RNU, except for 5-year OS in high-grade tumors which favoured RNU.
Ipsilateral pubic ramus fracture during total hip arthroplasty is not rare: does it matter?
Authors: Ko Young-Seung , Lee Han Jin , Kim Hong Seok , Yoo Jeong Joon 
Published: May 2024

Abstract
Introduction
Periprosthetic fractures in total hip arthroplasty (THA) have been well described and studied. However, there is a lack of reports on ipsilateral pubic ramus fractures during THA due to the rare occurrence of such fractures and ambiguity of symptoms. With the use of postoperative computed tomography (CT) examinations, we have identified that asymptomatic ipsilateral pubic ramus fractures occur frequently during THA. This study aims to evaluate the incidence, location, clinical outcomes, and risk factors of ipsilateral pubic ramus fractures during THA.

Methods
From May 2022 to March 2023, a single surgeon performed 203 THAs in 183 patients at a single institution. All patients underwent postoperative CT scans three days after THA. The patients with ipsilateral pubic ramus fractures were followed up for a minimum of six months. Basic demographics, osteoporosis, general conditions of the operations, and outcomes of THA were investigated in all patients.

Results
Twenty-two cases (10.8%) of ipsilateral pubic ramus fractures were identified on postoperative CT scans. All fractures were located near the origin of the superior or inferior pubic ramus. Five fractures were detected on simple postoperative radiographs. The fractures did not cause any further complications at a minimum of six-month postoperative follow-up. Univariate and multivariate analyses did not identify any risk factors associated with these fractures.

Conclusions
Although the incidence of ipsilateral pubic ramus fractures during THA is high, treatment is not required as they do not cause any significant clinical symptoms or affect the prognosis of THA. However, the possibility of occurrence of these fractures must be explained to the patients before surgery.
Effective Bounds for Induced Size-Ramsey Numbers of Cycles
Authors: Bradač Domagoj , Draganić Nemanja , Sudakov Benny 
Published: May 2024

AbstractThe induced size-Ramsey number $$\hat{r}_\text {ind}^k(H)$$

r
^

ind
k

(
H
)

of a graph H is the smallest number of edges a (host) graph G can have such that for any k-coloring of its edges, there exists a monochromatic copy of H which is an induced subgraph of G. In 1995, in their seminal paper, Haxell, Kohayakawa and Łuczak showed that for cycles, these numbers are linear for any constant number of colours, i.e., $$\hat{r}_\text {ind}^k(C_n)\le Cn$$

r
^

ind
k

(

C
n

)

≤
C
n

for some $$C=C(k)$$

C
=
C
(
k
)

. The constant C comes from the use of the regularity lemma, and has a tower type dependence on k. In this paper we significantly improve these bounds, showing that $$\hat{r}_\text {ind}^k(C_n)\le O(k^{102})n$$

r
^

ind
k

(

C
n

)

≤
O

(

k
102

)

n

when n is even, thus obtaining only a polynomial dependence of C on k. We also prove $$\hat{r}_\text {ind}^k(C_n)\le e^{O(k\log k)}n$$

r
^

ind
k

(

C
n

)

≤

e

O
(
k
log
k
)

n

for odd n, which almost matches the lower bound of $$e^{\Omega (k)}n$$

e

Ω
(
k
)

n

. Finally, we show that the ordinary (non-induced) size-Ramsey number satisfies $$\hat{r}^k(C_n)=e^{O(k)}n$$

r
^

k

(

C
n

)

=

e

O
(
k
)

n

for odd n. This substantially improves the best previous result of $$e^{O(k^2)}n$$

e

O
(

k
2

)

n

, and is best possible, up to the implied constant in the exponent. To achieve our results, we present a new host graph construction which, roughly speaking, reduces our task to finding a cycle of approximate given length in a graph with local sparsity.
Interdisziplinäres, kollaboratives D-A-CH Konsensus-Statement zur Diagnostik und Behandlung von Myalgischer Enzephalomyelitis/Chronischem Fatigue-Syndrom
Authors: Hoffmann Kathryn , Hainzl Astrid , Stingl Michael , Kurz Katharina , Biesenbach Beate , Bammer Christoph , Behrends Uta , Broxtermann Wolfgang , Buchmayer Florian , Cavini Anna Maria , Fretz Gregory Sacha , Gole Markus , Grande Bettina , Grande Tilman , Habermann-Horstmeier Lotte , Hackl Verena , Hamacher Jürg , Hermisson Joachim , King Martina , Kohl Sonja , Leiss Sandra , Litzlbauer Daniela , Renz-Polster Herbert , Ries Wolfgang , Sagelsdorff Jonas , Scheibenbogen Carmen , Schieffer Bernhard , Schön Lena , Schreiner Claudia , Thonhofer Kevin , Strasser Maja , Weber Thomas , Untersmayr Eva 
Published: May 2024

ZusammenfassungMyalgische Enzephalomyelitis/Chronisches Fatigue-Syndrom (ME/CFS) ist eine schwere, chronische Multisystemerkrankung, die je nach Ausprägung zu erheblichen körperlichen und kognitiven Einschränkungen, zum Verlust der Arbeitsfähigkeit bis hin zur Pflegebedürftigkeit einschließlich künstlicher Ernährung und in sehr schweren Fällen sogar zum Tod führen kann.
Das Ziel dieses D-A-CH-Konsensusstatements ist es, 1) den aktuellen Wissensstand zu ME/CFS zusammenzufassen, 2) in der Diagnostik die kanadischen Konsensuskriterien (CCC) als klinische Kriterien mit Fokus auf das Leitsymptom post-exertionelle Malaise (PEM) hervorzuheben und 3) vor allem im Hinblick auf Diagnostik und Therapie einen Überblick über aktuelle Optionen und mögliche zukünftige Entwicklungen aufzuzeigen. Das D-A-CH-Konsensusstatement soll Ärzt:innen, Therapeut:innen und Gutachter:innen dabei unterstützen, Patient:innen mit Verdacht auf ME/CFS mittels adäquater Anamnese und klinisch-physikalischen Untersuchungen sowie der empfohlenen klinischen CCC zu diagnostizieren und dabei die präsentierten Fragebögen sowie die weiteren Untersuchungsmethoden zu nutzen. Der Überblick über die zwei Säulen der Therapie bei ME/CFS, Pacing und die symptomlindernden Therapieoptionen sollen nicht nur Ärzt:innen und Therapeut:innen zur Orientierung dienen, sondern auch Entscheidungsträger:innen aus der Gesundheitspolitik und den Versicherungen darin unterstützen, welche Therapieoptionen bereits zu diesem Zeitpunkt bei der Indikation „ME/CFS“ von diesen erstattbar sein sollten.
Relationships of emerging biomarkers of cancer cachexia with quality of life, appetite, and cachexia
Authors: Lipshitz M. , Visser J. , Anderson R. , Nel DG. , Smit T. , Steel HC. , Rapoport BL. 
Published: May 2024

Abstract
Purpose
Quality of life (QoL), appetite, cachexia, and biomarkers [albumin, hemoglobin (Hb), neutrophils, lymphocytes, platelets, C-reactive protein (CRP), tumor necrosis factor alpha (TNFα), interleukin 6 (IL-6), interleukin 8 (IL-8), C-X-C motif chemokine ligand 5 (CXCL5) and citrullinated histoneH3 (H3Cit)] were compared for 40 cases with advanced cancer and 40 healthy controls. Baseline differences and significant relationships were explored for biomarkers with QoL, appetite, and cachexia.

Methods
In a prospective case–control, age and sex matched study, the European Organisation for the Research and Treatment of Cancer Quality of Life–C30 questionnaire (EORTC-QLQ-C30) for QoL, the Functional Assessment of Anorexia and Cachexia Therapy assessment (FAACT A/CS-12) for appetite, and a five-factor cachexia assessment tool for cachexia assessment were performed. Routine hematological measurements and blood chemistry analyses together with ELISA procedures and a Multiplex® bead array platform, were used for biomarker analysis. Descriptive statistics and regression analyses were undertaken. P < 0.05 defined statistical significance.

Results
Global health status (QL-G), functional scales (QL-FS), and symptom scales (QL-SS) differed for cases and controls (p < 0.01). In cases, differences were observed for QL-G (p < 0.01), QL-FS (p < 0.01), and QL-SS (p = 0.01) compared to standardized references values. FAACT A/CS-12 scores differed significantly between cases and controls (p < 0.01) and 30% of cases scored “poor” appetites. Cachexia was present in 60% of cases. Albumin, lymphocytes, platelets, Hb, platelet to lymphocyte ratio (PLR), systemic immune-inflammation index (SII), CRP, TNFα, all at p < 0.01, neutrophil to lymphocyte ratio (NLR) (p = 0.02), IL-6 (p < 0.04), and IL-8 (p = 0.02) differed significantly between cases and controls. No difference was found for CXCL5 or H3Cit. Albumin NLR, Hb, PLR, SII, TNFα, IL-8, and CRP showed significant relationships with all aspects of QoL. QL-FS was significantly related to CXCL5 (p = 0.04), significant relationships with FAACT A/CS-12 included: NLR (p = 0.002), Hb (p < 0.001), and PLR (p < 0.01). NLR, PLR, SII, TNFα, IL-6, IL-8, and CRP correlated positively to cachexia and albumin while Hb and lymphocyte count correlated negatively to cachexia.

Conclusion
CXCL5 and H3Cit were not reliable biomarkers for cancer cachexia, nor significantly related to QoL, appetite or cachexia. Albumin, NLR, Hb, PLR, SII, TNFα, IL-8, and CRP were reliable indicators of QoL, appetite, and cachexia. Future research should include other novel biomarkers namely growth differentiation factor-15 (GDF-15), fibroblast growth factor 21 (FGF-21), fractakline, interferon gamma (IFN-y), IL-16, macrophage colony stimulating factor (M-CSF), and macrophage procoagulant–inducing factor (MPIF).