bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personas de Género “No Binario” en el Sistema General de Pensiones Colombiano (SGP): Requisitos para el Acceso a las Prestaciones Económicas
Authors: Granados Ferreira Jackeline 
Published: February 2025

El propósito de esta disertación consiste en, realizar un análisis al sistema general de pensiones, relacionado con las personas género no binario una vez reúnen los requisitos para acceder a las prestaciones económicas, particularmente tratándose del requisito de la edad, esto en la medida en que, si bien es cierto, la corte constitucional estableció la inclusión en los documentos de identidad la calidad no binaria, no se refirió sobre este aspecto al sistema general de pensiones, generando de esta manera un vacío jurídico, toda vez que, solo decidió sobre las alternativas correspondientes al sexo del documento de identificación en Colombia, los cuales serían Masculino, Femenino y No binario, por esta razón nos proponemos mediante el método analítico–interpretativo, recopilar textos, artículos, libros y literatura relacionada con el tema planteado, realizaremos un rastreo de la jurisprudencia de la corte constitucional para interpretar las decisiones adoptadas y como resultado dar respuesta a la problemática planteada, sobre la siguiente pregunta ¿cuál sería la edad de la persona género no binario para pensionarse? en conclusión, no existe claridad jurídica sobre las personas género no binario al momento de solicitar las prestaciones económicas en el sistema General de pensiones colombiano.
MGL/SiNW-based exotic pin switch with low insertion loss and high isolation for THz communication: a quantum-rectified Schrodinger–Poisson drift-diffusion model for the design and analysis of switching behavior
Authors: Bhattacharya Saunak , Kundu Abhijit , Kundu Jhuma , Sarkar Angsuman , Mukherjee Moumita 
Published: February 2025

In this paper, the authors explore the potential of an exotic multi-graphene layer/Si nanowire (MGL/SiNW) pin device as a switch in the THz frequency domain. The device is developed by the incorporation of multiple SiNWs into its intrinsic region. In contrast, cap and bottom layers are developed by the incorporation of multiple graphene layers. The electrical characterization of the proposed exotic pin device is carried out by developing a quantum-rectified Schrodinger–Poisson drift-diffusion (QRSP-DD) model. The developed QRSP-DD model is validated by analyzing experimental and simulation observations under similar operating conditions. After establishing its validity, the same model in conjunction with the PSpice simulator is used to obtain the switching characteristics of MGL/SiNW pin-based series-shunt and shunt single-pole single-throw (SPST), single-pole double-throw (SPDT), and single-pole multiple-throw (SPMT) switches in the THz frequency domain. The analysis proves that the MGL/SiNW pin-based SPMT switch offers low resistance (0.56 Ω), high isolation (91.15 dB), and low insertion loss (0.007 dB) at 5 THz frequency compared to its SiNW counterpart.
The public are receptive to risk-based innovations: a multi-methods exploration of anticipated acceptability and uptake of novel technologies for cancer early detection in symptomatic and asymptomatic scenarios
Authors: Dennison Rebecca A. , Clune Reanna J. , Tung Joanna S. L. , Schumacher Alina A. , Solovyeva Maria , Pandey Pranjal , Taylor Lily C. , Waller Jo , Usher-Smith Juliet A. 
Published: February 2025

IntroductionNew technologies and innovations are emerging that enable stratification of individuals based on their risk of cancer and enable screening or diagnostic investigations to be targeted to those at greatest need. This study aimed to explore, in depth, attitudes of the UK public toward this concept; specifically, anticipated acceptability and uptake, including barriers and enablers toward uptake.MethodsA survey was completed independently by a representative population sample and alongside a researcher in think aloud interviews. Participants considered three of six exemplars of innovations that enable risk assessment: polygenic risk scores, geodemographic segmentation, continuous biomarker monitoring, minimally invasive tests, artificial intelligence analysis of medical records, and wearable devices. Questions about likelihood of taking up the risk assessment, acceptability of risk-stratified healthcare, and comfort about risk results being used within healthcare generally were set in asymptomatic then symptomatic scenarios. Descriptive statistics and multivariable logistic regression were used to explore differences between the exemplars and contexts and the impact of individual characteristics. Interviews were analyzed using codebook thematic analysis guided by the Theoretical Framework of Acceptability. Free-text comments were also analyzed thematically.Results999 participants completed the survey independently and 21 participants completed interviews. Most were extremely or somewhat likely to take up risk assessments, ranging from 62.0% for geodemographic segmentation to 85.2% for minimally invasive tests in the asymptomatic scenario, and from 64.2% for geodemographic segmentation to 94.0% for minimally invasive tests in the symptomatic scenario. Acceptability of using the exemplars within risk-stratified screening or referral pathways followed a similar pattern, as did comfort with the results being used widely. Qualitative analyses showed that the innovations and risk-based approach were viewed as proactive and logical. Tests requiring low burden were preferred, although most participants did not consider the burden of any of the innovations to be too high, particularly in the symptomatic context.ConclusionsRisk-based innovations for cancer early detection are intuitive. Study participants would be likely to engage and support their use for risk stratification, particularly for decisions about symptom investigations. These findings justify and promote ongoing research to develop these technologies and highlight features that increase public acceptability.
Men's more frequent predisposing factors in infectious endocarditis facilitate improvement of outcomes by shortening of diagnostic delay
Authors: Andreß S. , Reischmann K. , Markovic S. , Rohlmann F. , Hay B. , Rottbauer W. , Buckert D. , d'Almeida S. 
Published: February 2025

IntroductionDespite growing evidence for sex-specific differences in cardiovascular disease, sex is poorly considered in the management of infectious endocarditis (IE).PurposeThis study aimed to assess sex-specific aspects in diagnosing IE.MethodsAll consecutive patients admitted at Ulm University Heart Center with suspected IE between 2009 and 2019 were included. IE was diagnosed using the Duke criteria. Risk factors, clinical presentation and in-hospital outcomes along with the impact of diagnostic delay were compared between male and female patients.ResultsIE was diagnosed in 96 of 118 men (81.4%) and 33 of 45 women (73.3%) (p = 0.121). Time to diagnosis was similar between the groups (p = 0.598). Regarding patient characteristics, men were younger (65.5 vs. 74.3 years, p = 0.006). Men exhibited a higher prevalence of predisposing cardiac conditions (p = 0.012) due to a higher frequency of a history of implantable cardioverter defibrillator implantation (p = 0.004), and were more likely to have poor dental status (p = 0.001), and coronary artery disease (p = 0.002). The incidence of the complications of heart failure with reduced ejection fraction (p = 0.007) and new-onset dialysis (p = 0.012) were higher, the time in the intensive care unit (p = 0.012) longer. Male sex was the only independent risk factor for in-hospital mortality [p = 0.036, HR 4.127 (95%-CI 1.096-15.538)]. Notably, only in the male cohort, a shorter time to diagnosis was associated with a lower mortality rate (p = 0.035, optimal cut-point 3.5 days). Men diagnosed within 3.5 days had a mortality rate of 13.5% compared to 31.8% for those diagnosed later (p = 0.028).ConclusionMen with suspected IE are younger, have more predisposing factors and experience a more complicated course of disease, while benefiting from early diagnosis. Therefore, recognizing the heightened risk profile specific to men during diagnosis can help to address their poorer prognosis.
The relationship between negative psychological state and quality of life among cardiovascular disease patients in China: the masking effect of abnormal dietary behavior
Authors: Chang QingNing , Ma HaiBo , Zhang Can , Li Xin , Wu YiBo , Ha LiNa 
Published: February 2025

BackgroundIt is well known that abnormal dietary behavior increases the risk for cardiovascular disease especially if the person is depressed and/or anxious. The purpose of this study was to construct a moderated mediation model to explore the roles of abnormal dietary behavior and family health in the mechanism through which depression/anxiety influences Quality of life (QoL) in patients with cardiovascular disease.MethodsA field survey was conducted in China and ultimately included 730 patients with cardiovascular disease aged 20–60 years. Data were collected using the Europe Quality of five-dimensional five-level questionnaire, Short-Form of the Eating Behavior Scale, Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, and the Chinese version of the short-form of the Family Health Scale. All data were analyzed using SPSS Statistics 23.0.Results(1) Depression was negatively associated with QoL (r = −0.386/−0.230, p &lt; 0.001), and was positively correlated with abnormal dietary behavior (r = 0.377, p &lt; 0.001). Anxiety was negatively associated with QoL (r = −0.383/−0.231, p &lt; 0.001), and was positively correlated with abnormal dietary behavior (r = 0.333, p &lt; 0.001). Abnormal dietary behavior was negatively correlated with QoL (r = −0.077/−0.119, p = 0.039/0.001). (2) In the mediation model, abnormal dietary behavior only had a masking effect on the relationship between depression and QoL, with a mediating effect size of 7.18%. The mediating effect of abnormal dietary behavior between anxiety and QoL was not significant. (3) The mediating effect size of abnormal dietary behavior between depression/anxiety and QoL increased to 14.77% and 13.57% in unhealthy families. The above masking mediation effect was not significant in healthy families.ConclusionsAbnormal dietary behavior positively mediated the relationship between depression and QoL and attenuated the negative effect of depression on QoL in patients with cardiovascular disease. The masking mediating effect of abnormal dietary behavior between depression/anxiety and QoL was stronger for patients in unhealthy families.
Case Report: Dangerous liaisons between splenectomy and eltrombopag-induced chronic thromboembolic pulmonary hypertension in patients with immune thrombocytopenia: report of two cases and review of the literature
Authors: Castelli Roberto , Atzori Enrico , Delitala Alessandro Palmerio , Masala Salvatore Antonio , Micheluzzi Valentina , Ponti Enrico , Sanna Giuseppe , Castro Dante , Gidaro Antonio , Donadoni Mattia , Manetti Roberto , Merella Pierluigi , Profili Nicia Isabella , D'Armini Andrea Maria , Casu Gavino 
Published: February 2025

IntroductionPrimary immune thrombocytopenia is an autoimmune bleeding disorder characterized by variable immune-mediated platelet destruction. These patients have reported thrombotic complications, both venous and arterial, in addition to bleeding. Splenectomy and thrombopoietin receptor agonists are recommended for patients who do not respond to steroids or immunosuppressive treatments. Chronic thromboembolic pulmonary hypertension is a rare disease that results from a persistent, organized thromboembolic obstruction of the pulmonary arteries due to an incompletely resolved pulmonary embolism.Case presentationsWe report two cases of chronic thromboembolic pulmonary hypertension induced by a thrombotic mechanism after treatment with splenectomy and Eltrombopag, a thrombopoietin receptor agonist, for refractory primary immune thrombocytopenia. Consequently, the patients were referred for surgical pulmonary thromboendarterectomy therapy as suggested.ConclusionIn older patients, those with a history of thrombotic manifestations, or those with high-risk factors, clinicians should evaluate and monitor the risk of thrombotic events and chronic thromboembolic pulmonary hypertension when treating primary immune thrombocytopenia with splenectomy and Eltrombopag.
The role of artificial intelligence in aortic valve stenosis: a bibliometric analysis
Authors: Chen Shanshan , Wu Changde , Zhang Zhaojie , Liu Lingjuan , Zhu Yike , Hu Dingji , Jin Chenhui , Fu Haoya , Wu Jing , Liu Songqiao 
Published: February 2025

PurposeTo explore the expanding role of artificial intelligence (AI) in managing aortic valve stenosis (AVS) by bibliometric analysis to identify research trends, key contributors, and the impact of AI on enhancing diagnostic and therapeutic strategies for AVS.MethodsA comprehensive literature review was conducted using the Web of Science database, covering publications from January 1990 to March 2024. Articles were analyzed with bibliometric tools such as CiteSpace and VOSviewer to identify key research trends, core authors, institutions, and research hotspots in AI applications for AVS.ResultsA total of 118 articles were analyzed, showing a significant increase in publications from 2014 onwards. The results highlight the growing impact of AI in AVS, particularly in cardiac imaging and predictive modeling. Core authors and institutions, primarily from the U.S. and Germany, are driving research in this field. Key research hotspots include machine learning applications in diagnostics and personalized treatment strategies.ConclusionsAI is playing a transformative role in the diagnosis and treatment of AVS, improving accuracy and personalizing therapeutic approaches. Despite the progress, challenges such as model transparency and data security remain. Future research should focus on overcoming these challenges while enhancing collaboration among international institutions to further advance AI applications in cardiovascular medicine.
Integrated teaching methodology in the development of foreign language professional communicative competence on the discipline “organic chemistry” at Kazakhstan University
Authors: Kenzhe Aziza , Bitemirova Aliya , Bayan Ualikhanova , Bitursyn Saule , Zhorabekova Ainur 
Published: February 2025

IntroductionIn Kazakhstan, acquiring a foreign language is a prerequisite for advancing chemistry education, enabling students to access global scientific advancements, establish international professional connections, and exchange knowledge. This study examines the implementation of CLIL/ICLHE to enhance foreign language professional communicative competence (FLPCC) in chemistry. Based on this approach, a training model and a set of exercises were developed.MethodsA quasi-experimental design was employed to compare the results among third-year students enrolled in the “Chemistry Teacher Training” educational program divided into experimental and control groups through pre-test and post-test assessments. The experimental group received training based on modeling, while the control group received traditional teaching. The experimental set of exercises was implemented during the 5 and 6th semesters of the academic year. The experiment consisted of three stages: preparation stage, forming stage and verifying stage.ResultsAll data were analyzed using the independent samples t-test. The mean values and standard deviations for each criterion were evaluated in the control and experimental groups. The initial pre-test analysis indicated no significant differences between the groups, validating the equivalence of their baseline levels. However, after conducting the experiment, the results showed that the experimental group outperformed the control group across all measured criteria. These findings suggest that the proposed methodology positively influenced the development of various skills in students.DiscussionThe set of exercises was piloted during the experiment, and its effectiveness was evaluated through a comparison of pre-test and post-test results. The analysis using the t-test revealed a developmental trend across all criteria for the FLPCC components compared to the initial levels. However, one limitation of CLIL/ICLHE approach is that a single lesson may be insufficient to fully cover a single topic due to the extensive number of tasks involved. This limitation highlights the need for additional instructional time.
Exploring benefits of a collaborative Scottish university-organization alternative credentials approach to re-skilling
Authors: Smith Christopher J. M. , Choromides Constantinos , Clyde Alicia , Stewart-Knight Fiona 
Published: February 2025

IntroductionAlternative credentialed forms of learning provide important learning pathways for professionals to up-and re-skill. In Scotland, credit-rating of learning is one option to create these credentialed courses, based on national principles from the Scottish Credit and Qualifications Framework (SCQF) Partnership. However, there is currently almost no evidence on the benefits of such an approach for those involved, so this study focuses on examining the benefits of having a flexible national qualification system (SCQF) that allows ‘credit-rating’ of organizational learning.MethodsAn exploratory research methodology using a single case study design (based on one Scottish university) was used. Nine semi-structured interviews (with both learning providers and university employees) were inductively analyzed using a two-cycle thematic analysis approach to determine themes.ResultsThe SCQF guidance and the business-orientated nature of Scottish universities in credit-rating of learning were highlighted as an important enabler for this alternative form of credentialed learning to being possible. Value to learners focused on having a professionally relevant qualification that had validity, both through possible credit transfer to other programs and providing recognition of competence. Such credit transfer and entry into university programs is a benefit for the university and aligns to Scottish Government priorities of widening access as well as supporting up-and re-skilling. Credit-rating of learning also enhances the credibility of the learning provider’s offering and enhances their own quality assurance processes.DiscussionClear value to a range of stakeholders is created, with the university able to determine its own business model to provide credit-rating of learning, and this flexibility is important to align to institutional strategy, as well as to provide an effective, efficient service. It is recognized that credit-rating of learning co-creates value for the participants, and future research and opportunity lies around exploring this further. Credit-rating of learning has great potential to support national priorities, but this service needs to be better understood by companies and employers for it to reach its potential.
Immunologic and inflammatory consequences of SARS-CoV-2 infection and its implications in renal disease
Authors: Naiditch Hiam , Betts Michael R. , Larman H. Benjamin , Levi Moshe , Rosenberg Avi Z. 
Published: February 2025

The emergence of the COVID-19 pandemic made it critical to understand the immune and inflammatory responses to the SARS-CoV-2 virus. It became increasingly recognized that the immune response was a key mediator of illness severity and that its mechanisms needed to be better understood. Early infection of both tissue and immune cells, such as macrophages, leading to pyroptosis-mediated inflammasome production in an organ system critical for systemic oxygenation likely plays a central role in the morbidity wrought by SARS-CoV-2. Delayed transcription of Type I and Type III interferons by SARS-CoV-2 may lead to early disinhibition of viral replication. Cytokines such as interleukin-1 (IL-1), IL-6, IL-12, and tumor necrosis factor α (TNFα), some of which may be produced through mechanisms involving nuclear factor kappa B (NF-κB), likely contribute to the hyperinflammatory state in patients with severe COVID-19. Lymphopenia, more apparent among natural killer (NK) cells, CD8+ T-cells, and B-cells, can contribute to disease severity and may reflect direct cytopathic effects of SARS-CoV-2 or end-organ sequestration. Direct infection and immune activation of endothelial cells by SARS-CoV-2 may be a critical mechanism through which end-organ systems are impacted. In this context, endovascular neutrophil extracellular trap (NET) formation and microthrombi development can be seen in the lungs and other critical organs throughout the body, such as the heart, gut, and brain. The kidney may be among the most impacted extrapulmonary organ by SARS-CoV-2 infection owing to a high concentration of ACE2 and exposure to systemic SARS-CoV-2. In the kidney, acute tubular injury, early myofibroblast activation, and collapsing glomerulopathy in select populations likely account for COVID-19-related AKI and CKD development. The development of COVID-19-associated nephropathy (COVAN), in particular, may be mediated through IL-6 and signal transducer and activator of transcription 3 (STAT3) signaling, suggesting a direct connection between the COVID-19-related immune response and the development of chronic disease. Chronic manifestations of COVID-19 also include systemic conditions like Multisystem Inflammatory Syndrome in Children (MIS-C) and Adults (MIS-A) and post-acute sequelae of COVID-19 (PASC), which may reflect a spectrum of clinical presentations of persistent immune dysregulation. The lessons learned and those undergoing continued study likely have broad implications for understanding viral infections’ immunologic and inflammatory consequences beyond coronaviruses.
IFNλ1 is a STING-dependent mediator of DNA damage and induces immune activation in lung cancer
Authors: Godsk Stine Høvring , Jensen Caroline Maren Stengaard , Larsen Trine Vilsbøll , Ahrenfeldt Johanne , Gammelgaard Kristine Raaby , Jakobsen Martin Roelsgaard 
Published: February 2025

IntroductionThe importance of the cGAS-STING pathway and type I interferon (IFN) in anti-tumor immunity has been widely studied. However, there is limited knowledge about the role of type III IFNs in cancer settings. Type III IFNs, comprising IFNλ1-4, are opposite to type I IFN only expressed by a few cell types, including epithelial cells, and the receptor subunit IFNLR1, is equally only expressed on limited types of cells.MethodsGene and protein expression of the cGAS-STING signaling pathway was characterized in a series of non-small cell lung cancer (NSCLC) cell lines. Herring-testis DNA stimulation and chemotherapy drugs (doxorubicin and cisplatin) were used to activate the cGAS-STING pathway, and the level of activation was determined by measuring changes in the transcriptomic profile as well as type I and III IFNs by ELISA. Re-expression of IFNLR1 on cancer cell lines was achieved using CRISPR activation (CRISPRa) followed by evaluating chemotherapy-induced apoptosis using flow cytometry assays.ResultsSTING was not broadly expressed across the NSCLC cell lines. Those cancer cell lines expressing all relevant factors supporting the cGAS-STING pathway secreted IFNλ following STING activation whereas only few of them expressed IFNβ. Treatment with chemotherapy drugs likewise preferentially induced IFNλ, which was abrogated in CRISPR-Cas9 STING knock-out cells. Expression of IFNLR1 was found downregulated in the cancer cell lines compared to the benign epithelial cell line Nuli-1. Rescuing IFNLR1 expression by CRISPRa in multiple cancer cell lines sensitization them to IFNλ-stimulation and resulted in significant reduction in cell viability.ConclusionDownregulation of IFNLR1 can be an immune evasion mechanism developed by cancer cells to avoid responding to endogenous type III IFNs. Thus, rescuing IFNLR1 expression in NSCLC in conjunction to chemotherapy may potentially be harnessed to elevate the anti-tumoral responses.