bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penguatan Nilai-Nilai Moderasi Beragama: Implementasi Pembelajaran pada Sekolah Berkebutuhan Khusus di Ponorogo
Authors: Sari Ulfi Andrian , Nuruddien Muhammad , Arumawan Muhammad Muhsin 
Published: May 2024

Anak-anak berkebutuhan khusus masih ada yang diperlakukan diskriminatif di lingkungan masyarakat sehingga diperlukan pembelajaran berbasis moderasi beragama yang mengajarkan anti kekerasan,toleransi, patriotisme dan mencintai kearifan lokal daerahnya. Pembelajaran moderasi beragama untuk anak berkebutuhan khusus memiliki tantangan tersendiri karena mereka memiliki tingkat pemahaman dan komunikasi yang terbatas. Tujuan dari pengabdian ini untuk penguatan nilai-nilai moderasi beragama dan implementasinya dalam pembelajaran di sekolah berkebutuhan khusus, Metode pengabdian menggunakan Partici­pa­tory Action Research dengan langkah membuat rencana peng­abdian dengan analisis kebutuhan melalui observasi dan wawancara, pe­lak­sanaan kegiatan dengan workshop kepada guru-guru sekolah luar biasa dan evaluasi kegiatan dilakukan dengan memberikan google form kepada peserta. Hasil pengabdian 1) Sekolah membutuhkan integrasi pembelajaran dengan penguatan moderasi beragama. 2) Implementasi moderasi ber­agama dalam pembelajaran a) implementasi toleransi dengan edukasi dan keteladanan, b) implementasi anti kekerasan dengan edukasi pelaku kekerasan dan orangtua, memberi motivasi dan perlindungan pada korban, c) implementasi kearifan lokal dengan mengenalkan dan mempraktikkan budaya lokal dan d} implementasi patriotisme dengan mengenalkan simbol Negara Kesatuan Republik Indonesia dan praktik nasionalisme. 3) Evaluasi pengabdian menunjukkan semua guru sangat puas mengikuti pelatihan. Hasil tingkat pemahaman guru terkait nilai moderasi rata-rata pretest sebesar 69 % sedangkan nilai post test 90 % dengan peningkatan pemahaman peserta terhadap nilai-nilai moderasi beragama sebeser 21 %.
Hubungan Aktivitas Fisik Perminggu dengan Kebugaran Jasmani Siswa SMAN 1 Kepanjen
Authors: Isro’i Oktavian Gunansya  , M.E. Winarno  
Published: May 2024

Pada Penelitian ini untuk mengetahui adanya hubungan aktivitas fisik dengan kesegaran jasmani pada murid kelas 10 SMAN 1 Kepanjen. Metode yang di gunakan adalah metodologi deskriptif kuantitatif, desain korelasional. Populasinya adalah peserta didik kelas 10 SMA Negeri 1 Kepanjen berjumlah 408 siswa. Sampel yang diambil yang berjumlah 80 murid menggunakan Teknik purposive random sampling. Sampel penelitian sebanyak 80 murid. Menggunakan tes lari 60m, gantung angkat tubuh, lompat tegak, baring duduk, dan lari jarak sedang 1200m atau 1000m serta alat untuk mengukur aktivitas fisik PAQ (A), koefisisien korelasi rx.y = 0,287 > r (0,05) (80-2) = 0,2199 hasil dari aktivitas fisik dengan kesegaran jasmani lebih baik dari r tabel (0,2199). Kesimpulannya aktivitas fisik dan kesegaran jasmani positif secara signifikan
A Two-Year Observational Study to Evaluate Conversion Rates from High- and Low-Risk Patients with Amnestic Mild Cognitive Impairment to Probable Alzheimer’s Disease in a Real-World Setting
Authors: Jang Hyemin , Na Duk L. , Kwon Jay Cheol , Jung Na-Yeon , Moon Yeonsil , Lee Jung Seok , Park Kyung-Won , Lee Ae Young , Cho Hanna , Lee Jae-Hong , Kim Byeong C. , Park Kee Hyung , Lee Byung-Chul , Choi Hojin , Kim Jieun , Park Mee Young 
Published: May 2024

Background: Predicting conversion to probable Alzheimer&s disease (AD) from amnestic mild cognitive impairment (aMCI) is difficult but important. A nomogram was developed previously for determining the risk of 3-year probable AD conversion in aMCI. Objective: To compare the probable AD conversion rates with cognitive and neurodegenerative changes for 2 years from high- and low risk aMCI groups classified using the nomogram. Methods: This prospective, multicenter, observational study was conducted in Korea. A total of patients were classified as high- or low-risk aMCI according to the nomogram and followed-up for 2 years to compare the annual conversion rate to probable AD and brain structure changes between the two groups. Results: In total, 176 (high-risk, 85; low-risk, 91) and 160 (high-risk, 77; low-risk, 83) patients completed the 1-year and 2-year follow-up, respectively. The probable AD conversion rate was significantly higher in the high-risk (Year 1, 28.9%; Year 2, 46.1%) versus low-risk group (Year 1, 0.0%; Year 2, 4.9%, both p < 0.0001). Mean changes from baseline in Seoul Neuropsychological Screening Battery-Dementia Version, Clinical Dementia Rating-Sum of Box, and Korean version of the Instrumental Activities of Daily Living scores and cortical atrophy index at Years 1 and 2 were significantly greater in the high-risk group (p < 0.0001). Conclusions: The high-risk aMCI group, as determined by the nomogram, had a higher conversion rate to probable AD and faster cognitive decline and neurodegeneration change than the low-risk group. These real-world results have clinical implications that help clinicians in accurately predicting patient outcomes and facilitating early decision-making. Trial Registration: ClinicalTrials.gov (NCT03448445)
Associations of Allostatic Load with Level of and Change in Cognitive Function Among Middle-Aged and Older Hispanic/Latino Adults: The Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)
Authors: Estrella Mayra L. , Tarraf Wassim , Kuwayama Sayaka , Gallo Linda C. , Salazar Christian R. , Stickel Ariana M. , Mattei Josiemer , Vásquez Priscilla M. , Eldeirawi Kamal M. , Perreira Krista M. , Penedo Frank J. , Isasi Carmen R. , Cai Jianwen , Zeng Donglin , González Hector M. , Daviglus Martha L. , Lamar Melissa 
Published: May 2024

Background: Higher allostatic load (AL), a multi-system measure of physiological dysregulation considered a proxy for chronic stress exposure, is associated with poorer global cognition (GC) in older non-Hispanic white adults. However, evidence of these associations in middle-aged and older US-based Hispanic/Latino adults is limited. Objective: To examine associations of AL with level of cognition, performance in cognition 7 years later, and change in cognition over 7 years among middle-aged and older US-based Hispanic/Latino adults. Methods: We used data ( n = 5,799, 45–74 years at baseline) from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) and SOL-Investigation of Neurocognitive Aging (SOL-INCA). The AL score comprised 16 biomarkers representing cardiometabolic, glucose, cardiopulmonary, parasympathetic, and inflammatory systems (higher scores = greater dysregulation). Cognitive outcomes included GC and individual tests of verbal learning and memory, world fluency (WF), Digit Symbol Substitution (DSS), and Trail Making (Parts A & B). Survey-linear regressions assessed associations of AL with performance in cognition at baseline, 7 years later, and via 7-year cognitive change scores adjusting for sociodemographic characteristics, lifestyle factors, and depressive symptoms. Results: Higher AL was associated with lower baseline performance in GC and WF; and lower 7-year follow-up performance in these same measures plus DSS and Trail Making Parts A & B. Higher AL was associated with more pronounced 7-year change (reduction) in GC and on WF and DSS tests. Conclusions: Findings extend previous evidence in predominantly older non-Hispanic white cohorts to show that AL is related to level of and change in GC (as well as WF and DSS) among middle-aged and older US-based Hispanic/Latino adults.
Network Hyperexcitability in Early-Stage Alzheimer’s Disease: Evaluation of Functional Connectivity Biomarkers in a Computational Disease Model
Authors: Stam Cornelis Jan , de Haan Willem 
Published: May 2024

Background: There is increasing evidence from animal and clinical studies that network hyperexcitability (NH) may be an important pathophysiological process and potential target for treatment in early Alzheimer’s disease (AD). Measures of functional connectivity (FC) have been proposed as promising biomarkers for NH, but it is unknown which measure has the highest sensitivity for early-stage changes in the excitation/inhibition balance. Objective: We aim to test the performance of different FC measures in detecting NH at the earliest stage using a computational approach. Methods: We use a whole brain computational model of activity dependent degeneration to simulate progressive AD pathology and NH. We investigate if and at what stage four measures of FC (amplitude envelope correlation corrected [AECc], phase lag index [PLI], joint permutation entropy [JPE] and a new measure: phase lag time [PLT]) can detect early-stage AD pathophysiology. Results: The activity dependent degeneration model replicates spectral changes in line with clinical data and demonstrates increasing NH. Compared to relative theta power as a gold standard the AECc and PLI are shown to be less sensitive in detecting early-stage NH and AD-related neurophysiological abnormalities, while the JPE and the PLT show more sensitivity with excellent test characteristics. Conclusions: Novel FC measures, which are better in detecting rapid fluctuations in neural activity and connectivity, may be superior to well-known measures such as the AECc and PLI in detecting early phase neurophysiological abnormalities and in particular NH in AD. These markers could improve early diagnosis and treatment target identification.
Socio-Cognitive Determinants of Lifestyle Behavior in the Context of Dementia Risk Reduction: A Population-Based Study in the Netherlands
Authors: Bruinsma Jeroen , Loukas Vasileios S. , Kassiotis Thomas , Heger Irene , Rosenberg Anna , Visser Leonie N. C. , Mangialasche Francesca , Fotiadis Dimitrios I. , Hanke Sten , Crutzen Rik 
Published: May 2024

Background: Unhealthy behavior increases the risk of dementia. Various socio-cognitive determinants influence whether individuals persist in or alter these unhealthy behaviors. Objective: This study identifies relevant determinants of behavior associated to dementia risk. Methods: 4,104 Dutch individuals (40–79 years) completed a screening questionnaire exploring lifestyle behaviors associated with dementia risk. Subsequently, 3,065 respondents who engaged in one or more unhealthy behaviors completed a follow-up questionnaire investigating socio-cognitive determinants of these behaviors. Cross-tables were used to assess the accuracy of participants’ perceptions regarding their behavior compared to recommendations. Confidence Interval-Based Estimation of Relevance (CIBER) was used to identify the most relevant determinants of behavior based on visual inspection and interpretation. Results: Among the respondents, 91.3% reported at least one, while 65% reported two or more unhealthy lifestyle behaviors associated to dementia risk. Many of them were not aware they did not adhere to lifestyle recommendations. The most relevant determinants identified include attitudes (i.e., lacking a passion for cooking and finding pleasure in drinking alcohol or smoking), misperceptions on social comparisons (i.e., overestimating healthy diet intake and underestimating alcohol intake), and low perceived behavioral control (i.e., regarding changing physical inactivity, altering diet patterns, and smoking cessation). Conclusions: Individual-level interventions that encourage lifestyle change should focus on enhancing accurate perceptions of behaviors compared to recommendations, while strengthening perceived control towards behavior change. Given the high prevalence of dementia risk factors, combining interventions at both individual and environmental levels are likely to be the most effective strategy to reduce dementia on a population scale.
Pharmacologic and Nutritional Interventions for Early Alzheimer’s Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Authors: Zeng Baoqi , Tang Chunbian , Wang Junjian , Yang Qingqing , Ren Qingcuo , Liu Xiaozhi 
Published: May 2024

Background: Early intervention is essential for meaningful disease modification in Alzheimer’s disease (AD). Objective: We aimed to determine the efficacy and safety of pharmacologic and nutritional interventions for early AD. Methods: PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov were searched from database inception until 1 September 2023. We included randomized controlled trials that evaluated the efficacy of interventions in early AD. Only interventions that demonstrated efficacy compared to placebo were included in the network meta-analysis (NMA). Then we performed frequentist fixed-effects NMA to rank the interventions. GRADE criteria were used to evaluate the level of evidence. Results: Fifty-eight trials including a total of 33,864 participants and 48 interventions were eligible for inclusion. Among the 48 interventions analyzed, only 6 (12.5%) treatments— ranging from low to high certainty— showed significant improvement in cognitive decline compared to placebo. High certainty evidence indicated that donanemab (standardized mean difference [SMD] –0.239, 95% confidence interval [CI] –0.343 to –0.134) and lecanemab (SMD –0.194, 95% CI –0.279 to –0.108) moderately slowed the clinical progression in patients with amyloid pathology. Additionally, methylphenidate, donepezil, LipiDiDiet, and aducanumab with low certainty showed significant improvement in cognitive decline compared to placebo. However, there was no significant difference in serious adverse events as reported between the six interventions and placebo. Conclusions: Only 12.5% of interventions studied demonstrated efficacy in reducing cognitive impairment in early AD. Donanemab and lecanemab have the potential to moderately slow the clinical progression in patients with amyloid pathology. Further evidence is required for early intervention in AD.
Comparison of prognosis between hyperbilirubinemic infants with and without hypernatremia
Authors: Zakerihamidi M. , Moradi A. , Ramazani A. , Boskabadi H. 
Published: May 2024

OBJECTIVES: Hypernatremia may facilitate the diffusion of bilirubin through the blood-brain barrier and increase the risk of bilirubin encephalopathy. This study was conducted to compare the prognosis of jaundice infants with those with jaundice and hypernatremia. METHODS: A total of 615 term infants with idiopathic jaundice with or without hypernatremia were enrolled in this cohort study with 24-months follow-up at Ghaem Hospital, Mashhad, Iran, between 2010 and 2022. An in-house questionnaire including the laboratory evaluation and neonatal characteristics was used as the data collection tool. The follow-up of neonatal development status was performed using the Denver test II at 6, 12, 18, and 24 months after discharging from hospital. RESULTS: Normal outcomes were seen in 555 (90.2%) out of 615 studied infants, while 60 cases (9.8%) showed abnormal outcomes. Serum levels of sodium ( P = 0.017), bilirubin ( P = 0.001), urea ( P = 0.024), and creatinine ( P = 0.011) as well as hyperthermia ( P = 0.046) and unconsciousness ( P = 0.005) showed significant differences between the two groups. Approximately 16% of the newborns with both jaundice and hypernatremia, and 9% of those with only jaundice had unfavorable prognoses. Also, bilirubin level had the most predictive power (91.3%). CONCLUSIONS: Our results suggest that hypernatremia or jaundice alone, may affect the prognosis of infants aged 2 years; but jaundice and hypernatremia together, will intensify the developmental problems in jaundice infants. However, the role of hyperbilirubinemia in the incidence of complications is more than hypernatremia.
Fundamentals of Classical and Supersymmetric Quantum Stochastic Filtering Theory
Authors: Parthasarathy Harish 
Published: May 2024

In this paper, we first derive the discrete time recursive stochastic filtering equations for a classical Markov process when noisy measurements of the process are made with the measurement noise at each discrete sample forms an iid Gaussian or non-Gaussian process. The filter involves deriving general formulae for the conditional mean process given measurements upto that time and also simultaneously recursive formulae for the conditional moments of the estimation error process. In the next section, we build upon the method of John Gough etal, to construct a supersymmetric quantum stochastic filter, ie, the supersymmetric Belavkin filter. The construction of supersymmetric noise in the Hudson Parthasarathy noisy Schrodinger equation is based on constructing Fermionic noise by applying a twist to Bosonic noise, ie, \(dJ=(-1)^{\Lambda}dA, dJ^*=(-1)^{\Lambda}dA^*\). Such a Fermionic noise has memory unlike the Bosonic noise and satisfies the CAR. We prove that when a superposition of Bosonic quantum Brownian motion and Bosonic counting process along with Fermionic counting process is measured through the Hudson-Parthasarathy noisy Schrodinger system with both Bosonic and supersymmetric noise, then it satisfies the non-demolition property and hence conditional expectations can be defined. The construction of the quantum filter here involves taking into consideration all the positive integer powers of the output measurement noise differential and we give an algorithm for computing these powers based on the quantum Ito formula. The method for deriving a countably infinite number of linear equations for the filter coefficients is based on the reference probability method of Gough et.al. The method of constructing supersymmetric noise for driving the HPS equation is based on the work of Timothy Eyre. The main result of this paper is to derive an infinite system of linear equations for the quantum filter coefficients thereby yielding a real time implementable filter for estimating system observables or equivalently, the system mixed state from the most general form of non-demolition measurements comprising Bosonic continuous and counting noise plus Fermionic counting noise.
An American Founder's Dream
Authors: Young Christopher 
Published: May 2024

For a number of years my students in both the first half of the American history survey and in an upper-division course on the Early Republic have started their semesters by analyzing the subconscious of Benjamin Rush, a Philadelphia physician and a prominent member of the American revolutionary generation . Rush's recounting of one of his dreams offers an excellent opportunity for introducing students to the craft of analyzing primary sources for what they reveal about a particular time period or place in the past. Moreover, Rush's dream allows for considerations regarding the nature of history itself.
Writing and reporting on dreams was nothing new for Benjamin Rush. He was fascinated with this facet of human existence and spent time studying and lecturing on the topic . The vividness with which Rush was able to communicate his dreams was admired by John Adams who declared in 1805, upon reading Rush 's account of a dream, "I admire the brilliancy of your invention when asleep." Four years later, in 1809, Adams wrote to his friend, "If I could dream as much wit as you, I think I should wish to go to sleep for the rest of my life, retaining, however, one of Swift's flappers to awake me once in 24 hours to dinner, for you know without a dinner one can neither dream nor sleep."
Influence of Sustainable Grout Material on the Moisture Damage of Semi-flexible Pavement
Authors: Al-Nawasir Rania , Al-Humeidawi Basim , Shubbar Ali 
Published: May 2024

Semi-flexible pavement (SFP), also known as grouted pavement, is a type of pavement structure consisting of a porous asphalt skeleton with air voids between 25 and 35% injected with cementitious grout materials. The special skeleton of SFP provided enhanced durability and resilience, making it a promising option for the construction of road surfaces in high-traffic areas and severe conditions. The main aim of the current research is to investigate the rutting behavior and moisture resilience of SFP-containing sustainable grout using ceramic waste powder (CWP). This research introduced the use of CWP as a replacement for conventional grout (cement) in SFP for the first time. CWP partially replaced cement at ratios of 15, 20, 30, 40, and 50% of the cement weight. Indirect Tensile Strength (ITS) and Hamburg Wheel Tracking Tests (HWTT) were used to evaluate the performance of SFP to reduce the detrimental effect of moisture. The grout modified with CWP shows excellent results in the ITS and Tensile Strength Ratio (TSR), and all modified SFP mixtures give higher values in these tests compared with Control Mix (CM). In the HWTT, the minimum rut depth of the modified SFP was 2.8 mm and 3.10 mm. Compared to CM, rutting decreased by 73%–76% for CWP mixes with 20% and 30% replacement. This indicates the high fluidity of CWP, which enabled it to penetrate all voids in the porous pavement (PA) and form a dense microstructure due to its excellent pozzolanic interaction, making it a strong structure capable of bearing rutting.
Ferroptosis inducers – erastin and analogues (review)
Authors: Sanarova E. V. , Lantsova A. V. , Nikolaeva L. L. , Oborotova N. A. , Borisova L. M. 
Published: May 2024

Introduction.Improving the efficacy of chemotherapy is a non-trivial task of modern oncology. Its successful solution requires knowledge in many fields, including physiology, pathology, clinical oncology, pharmacology and others. The search for small molecules that selectively kill tumor cells led to the accidental discovery of erastin.Text.Erastin is a unique molecule that has a quinazoline fragment in its structure. Not so long ago it became known that the antitumour effect of this compound is due to the induction of ferroptosis – an iron-dependent form of cell death caused by lipid peroxidation. Erastin is able to induce ferroptosis through various biochemical pathways, including blocking of cystine-glutamate transport channel of cell membrane and potential-dependent anion channel of mitochondria, as well as activation of p53 protein.Conclusion.Pharmacological induction of ferroptosis by erastin and its analogues represents a promising direction in cancer chemotherapy. In addition, erastin and its analogues are able to increase sensitivity to chemotherapy and radiation therapy, which allows us to talk about the possibility of their use in the combined treatment of malignant neoplasms.
Comparative transcriptomics revealed neurodevelopmental impairments and ferroptosis induced by extremely small iron oxide nanoparticles
Authors: Lyu Zhaojie , Kou Yao , Fu Yao , Xie Yuxuan , Yang Bo , Zhu Hongjie , Tian Jing 
Published: May 2024

Iron oxide nanoparticles are a type of nanomaterial composed of iron oxide (Fe3O4 or Fe2O3) and have a wide range of applications in magnetic resonance imaging. Compared to iron oxide nanoparticles, extremely small iron oxide nanoparticles (ESIONPs) (∼3 nm in diameter) can improve the imaging performance due to a smaller size. However, there are currently no reports on the potential toxic effects of ESIONPs on the human body. In this study, we applied ESIONPs to a zebrafish model and performed weighted gene co-expression network analysis (WGCNA) on differentially expressed genes (DEGs) in zebrafish embryos of 48 hpf, 72 hpf, 96 hpf, and 120 hpf using RNA-seq technology. The key hub genes related to neurotoxicity and ferroptosis were identified, and further experiments also demonstrated that ESIONPs impaired the neuronal and muscle development of zebrafish, and induced ferroptosis, leading to oxidative stress, cell apoptosis, and inflammatory response. Here, for the first time, we analyzed the potential toxic effects of ESIONPs through WGCNA. Our studies indicate that ESIONPs might have neurotoxicity and could induce ferroptosis, while abnormal accumulation of iron ions might increase the risk of early degenerative neurological diseases.