bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative analysis of particulate bovine bone substitutes for oral regeneration: a narrative review
Authors: Pabst Andreas , Becker Philipp , Götz Werner , Heimes Diana , Thiem Daniel G.E. , Blatt Sebastian , Kämmerer Peer W. 
Published: May 2024

Abstract
Purpose
Particulate bovine bone substitutes (BS) are commonly used in oral regeneration. However, more literature is needed focusing on comparative analyses among various particulate bovine BS. This study evaluates pre-clinical and clinical data of different particulate bovine BS in oral regeneration.

Methods
A narrative review was conducted by screening the PubMed database Included in the review were pre-clinical and clinical studies until 2024 comparing a minimum of two distinct particulate bovine BS. In addition to examining general data concerning manufacturing and treatment processes, biological safety, physical and chemical characteristics, and graft resorption, particular emphasis was placed on assessing pre-clinical and clinical data related to ridge preservation, sinus floor elevation, peri-implant defects, and various forms of alveolar ridge augmentation utilizing particulate bovine BS.

Results
Various treatment temperatures ranging from 300 to 1,250 °C and the employment of chemical cleaning steps were identified for the manufacturing process of particulate bovine BS deemed to possess biosecurity. A notable heterogeneity was observed in the physical and chemical characteristics of particulate bovine BS, with minimal or negligible graft resorption. Variations were evident in particle and pore sizes and the porosity of particulate bovine BS. Pre-clinical assessments noted a marginal inclination towards favorable outcomes for particulate bovine BS subjected to higher treatment temperatures. However, clinical data are insufficient. No distinctions were observed regarding ridge preservation, while slight advantages were noted for high-temperature treated particulate bovine BS in sinus floor elevation.

Conclusions
Subtle variances in both pre-clinical and clinical outcomes were observed in across various particulate bovine BS. Due to inadequate data, numerous considerations related to diverse particulate bovine BS, including peri-implant defects, must be more conclusive. Additional clinical studies are imperative to address these knowledge gaps effectively.

Graphical abstract
Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Authors: Chu Liu-Xi , Wang Wen-Jia , Gu Xin-Pei , Wu Ping , Gao Chen , Zhang Quan , Wu Jia , Jiang Da-Wei , Huang Jun-Qing , Ying Xin-Wang , Shen Jia-Men , Jiang Yi , Luo Li-Hua , Xu Jun-Peng , Ying Yi-Bo , Chen Hao-Man , Fang Ao , Feng Zun-Yong , An Shu-Hong , Li Xiao-Kun , Wang Zhou-Guang 
Published: May 2024

AbstractAging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through a lens that encompasses both spatial and temporal dimensions. Conventional omics methodologies, such as genomics and transcriptomics, have been instrumental in identifying critical molecular facets of aging and regeneration. However, these methods are somewhat limited, constrained by their spatial resolution and their lack of capacity to dynamically represent tissue alterations. The advent of emerging spatiotemporal multi-omics approaches, encompassing transcriptomics, proteomics, metabolomics, and epigenomics, furnishes comprehensive insights into these intricate molecular dynamics. These sophisticated techniques facilitate accurate delineation of molecular patterns across an array of cells, tissues, and organs, thereby offering an in-depth understanding of the fundamental mechanisms at play. This review meticulously examines the significance of spatiotemporal multi-omics in the realms of aging and regeneration research. It underscores how these methodologies augment our comprehension of molecular dynamics, cellular interactions, and signaling pathways. Initially, the review delineates the foundational principles underpinning these methods, followed by an evaluation of their recent applications within the field. The review ultimately concludes by addressing the prevailing challenges and projecting future advancements in the field. Indubitably, spatiotemporal multi-omics are instrumental in deciphering the complexities inherent in aging and regeneration, thus charting a course toward potential therapeutic innovations.
Surgical treatment for pulmonary metastasis from ovarian cancer: a retrospective case series
Authors: Tsubouchi Saki , Tsukamoto Yo , Ishikawa Ai , Shigemori Rintaro , Kato Daiki , Shibazaki Takamasa , Mori Shohei , Nakada Takeo , Odaka Makoto , Ohtsuka Takashi 
Published: May 2024

Abstract
Background
Distant metastases of ovarian cancer are rarely detected alone. The effectiveness of surgical intervention for pulmonary metastases from ovarian cancer remains uncertain. This study aimed to investigate the clinicopathologic characteristics and outcomes of patients undergoing resection for pulmonary metastasis from ovarian cancer.

Case presentation
The clinicopathologic characteristics and outcomes of radical surgery for pulmonary metastasis from ovarian cancer were investigated. Out of 537 patients who underwent pulmonary metastasis resection at two affiliated hospitals between 2010 and 2021, four (0.74%) patients who underwent radical surgery for pulmonary metastasis from ovarian cancer were included. The patients were aged 67, 47, 21, and 59 years; the intervals from primary surgery to detection of pulmonary metastasis from ovarian cancer were 94, 21, 36, and 50 months; and the overall survival times after pulmonary metastasectomy were 53, 50, 94, and 34 months, respectively. Three of the four patients experienced recurrence after pulmonary metastasectomy. Further, preoperative carbohydrate antigen (CA) 125 levels were normal in two surviving patients and elevated in the two deceased patients.

Conclusion
In this study, three of the four patients experienced recurrence after pulmonary metastasectomy, but all patients survived for > 30 months after surgery. Patients with ovarian cancer and elevated CA125 levels may not be optimal candidates for pulmonary metastasectomy. To establish appropriate criteria for pulmonary metastasectomy in patients with ovarian cancer, further research on a larger patient cohort is warranted.
Dominance structure and constancy of spiders in the Indian Thar desert
Authors: Kashmeera Neisseril Anirudhan , Sudhikumar Ambalaparambil Vasu 
Published: May 2024

Abstract
Background
The knowledge about the species of a habitat (both resident and transient/dominant and rare) is a vital step to plan the conservation measures. Being generalist predators, spiders help controlling the population of their prey and maintain ecosystem stability. This makes spiders excellent bio-indicators for assessing the impact of anthropogenic disturbance factors on natural ecosystems (De, Siliwal, Uniyal and Hussain in Trop. Ecol. 63: 1–7, 2021). The aim of this study was to assess the dominance structure and constancy of spiders in three different habitats (Sand dunes, Riparian and Rocky) of the Thar desert. Study was conducted from March 2017 to February 2019 covering all seasons.

Results
The eudominant species in sand dunes and rocky desert belonged to the family Thomisidae. These species were Tmarus sp. 1 and Tmarus kotigeharus Tikader, 1963, respectively. There were two eudominants in Riparian habitat (Oecobius putus O. Pickard-Cambridge, 1876 and Menemerus bivittatus (Dufour, 1831)). Through the analysis of constancy of all the species in the Thar desert, it was revealed that three species were constant in all the three habitats. The number of accessory and accidental species was far higher than constant species in all the habitats.

Conclusions
The number of accessory and accidental spider species in all habitats was far higher than constants due to the unstability of spider population. Therefore, this study highlights the necessity for conservation of these habitats of the Thar desert.
Investigating the bacterial consortia properties of electrogenic anodic biofilm in a double-chamber microbial fuel cell: electrochemical, physical, biochemical and molecular characterization
Authors: Zater Doaa Khodary , Elzamik Fatma I. , Abdel Basit Howaida M. , Moustafa Gamal El-Din M. , Khater Dena Z. , El-Khatib Kamel M. 
Published: May 2024

AbstractThis work evaluated the electrochemical, physical, biochemical, and molecular characterization of electrogens from a graphite felt anode when zinc oxide on activated carbon (ZnO/AC) was used as a cathodic electrocatalyst in a double-chambered microbial fuel cell (DCMFC). The electrochemical polarization behavior of the DCMFC showed that ZnO/AC had a higher power density (PDmax) of 89 mW m−2 with a corresponding cell current density (CD) of 248 mA m−2 and a voltage output of 395 mV, which was higher than those of the blank electrode used as a benchmark (PDmax of 68 mW m−2 at a CD of 161 mA m−2 and a voltage of 421 mV). Furthermore, scanning electron microscopy and transmission electron microscopy revealed that the morphology and interior properties of the strains varied among the rods (bacilli), spirals (vibrios), and spheres (diplococci, staphylococci and streptococci). In addition, biochemical characterization via the Vitek2 compact system and molecular analysis via 16 S rRNA and 18 S rRNA gene sequencing revealed the occurrence of nine prevalent species that were correlated with Sphingobacterium spiritivorum, Ochrobactrum anthropicus, Pseudomonas mendocina, Stenotrophomonas maltophilia, Leuconostoc mesenteroides, Staphylococcus equorum, Bacillus subtilis HQ334981.1, Kocuria kristinae KC581674.1 and Saccharomyces cerevisiae NR111007.1. Consequently, the present study outlines different characterization strategies for electrogenic microbes that play an important role in the overall performance of DCMFC for scaling up and managing existing environmental pollution for sustainable energy generation.
Prognosis of transarterial chemoembolization-sorafenib compared to transarterial chemoembolization-alone in hepatocellular carcinoma stage C: a systematic review
Authors: Mulyadi Rahmad , Hasan Irsan , Sidipratomo Prijo , Putri Pungky Permata 
Published: May 2024

Abstract
Background
This systematic review aims to compare the prognosis of treatment transarterial chemoembolization (TACE) combined with sorafenib and TACE-alone in patients with hepatocellular carcinoma (HCC) with Barcelona clinic liver cancer-stage C (BCLC-C).

Materials and methods
A systematic search was conducted on five electronic databases: PubMed, ScienceDirect, Cochrane, Embase, and Scopus. Studies were included if they compared overall survival (OS) of TACE-Sorafenib to TACE-alone in patients with HCC BCLC-C within the 2019–2023 timeframe. We excluded studies consisting of conference abstracts, letters, editorials, guidelines, case reports, animal studies, trial registries, and unpublished work. The selected articles were evaluated from August 2023 to September 2023. The journal’s quality was assessed with NOS for a non-randomized controlled trial.

Results
This systematic review included four studies following the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA). All four studies compared the OS of 401 patients with TACE-sorafenib to TACE-alone. Two studies compared time-to-progression (TTP), one study compared progression-free survival (PFS), and two studies compared disease control rate (DCR). There were various population criteria, TACE techniques used, risk factors, follow-up time, and adverse events. The collected evidence generally suggested that the combination of TACE-sorafenib is superior compared to TACE-alone. Due to a lack of essential data for the included study, a meta-analysis couldn't be performed.

Conclusion
The results of this systematic review suggested that TACE-sorafenib combination therapy in patients with HCC BCLC-C improves OS superior compared to TACE-alone, without a notable increase in adverse events.
Comparative study between ultrasound and MR enterography in evaluation of Crohn’s disease
Authors: Mahdy Nada Sayed , El-Gaafary Sahar Mohammed , Mageed Khaled Hamdy Abdel , Shehata Khaled A. Ali , AbdelKarim Maha Ahmed Sayed , Abdulhafiz Essam Mohamed 
Published: May 2024

Abstract
Background
Crohn’s disease is a chronic inflammatory bowel disease that can affect any part of the gut. Endoscopy is the gold standard for diagnosis, but it only assesses mucosal lesions. Magnetic resonance enterography (MRE) can assess disease presence and activity, but it has limitations such as motion sensitivity, long scan time, and high cost. Bowel sonography has been introduced as a non-invasive, practical, safe, and low-cost technique to assess disease activity and complications. In our study we aim to assess the comparability of ultrasound to MRE in evaluation of patients with Crohn’s disease, and its complications.

Results
Twenty-five patients with 38 Crohn’s disease affected segments were evaluated by bowel ultrasound (BUS) and MRI enterography (MRE), where BUS and MRE showed equivalent diagnostic performance for disease detection and localization (97.4%, 100%), for sensitivity and specificity of both modalities. Peri-mural fluid (89.5%, 94.4%) and mural stratification loss (100%, 100%) showed high sensitivity and specificity by BUS compared to MRE, while for assessment of mural vascularity, BUS showed high sensitivity and specificity for high grade vascularity (100%, 83.3%), but low sensitivity and high specificity for low and moderate vascularity (0%–62.5%, 81.8%) compared to MRE. Complications including fistulae and abscessed were all correctly identified in BUS compared to MRE.

Conclusion
BUS showed comparable results to MRE for identification, localization, assessment of findings related to disease activity, and complications in cases of Crohn’s disease rendering it a viable alternative to MRE.
Investigating the association of opioid prescription with the incidence of psychiatric disorders: nationwide cohort study in South Korea
Authors: Oh Tak Kyu , Park Hye Yoon , Song In-Ae 
Published: May 2024

BackgroundThe relationship between opioid use and the incidence of psychiatric disorders remains unidentified.AimsThis study examined the association between the incidence of psychiatric disorders and opioid use.MethodData for this population-based cohort study were obtained from the National Health Insurance Service of South Korea. The study included all adult patients who received opioids in 2016. The control group comprised individuals who did not receive opioids in 2016, and were selected using a 1:1 stratified random sampling procedure. Patients with a history of psychiatric disorders diagnosed in 2016 were excluded. The primary end-point was the diagnosis of psychiatric disorders, evaluated from 1 January 2017 to 31 December 2021. Psychiatric disorders included schizophrenia, mood disorders, anxiety and others.ResultsThe analysis included 3 505 982 participants. Opioids were prescribed to 1 455 829 (41.5%) of these participants in 2016. Specifically, 1 187 453 (33.9%) individuals received opioids for 1–89 days, whereas 268 376 (7.7%) received opioids for ≥90 days. In the multivariable Cox regression model, those who received opioids had a 13% higher incidence of psychiatric disorder than those who did not (hazard ratio 1.13; 95% CI 1.13–1.14). Furthermore, both those prescribed opioids for 1–89 days and for ≥90 days had 13% (hazard ratio 1.13, 95% CI 1.12–1.14) and 17% (hazard ratio 1.17, 95% CI 1.16–1.18) higher incidences of psychiatric disorders, respectively, compared with those who did not receive opioids.ConclusionsThis study revealed that increased psychiatric disorders were associated with opioid medication use. The association was significant among both short- and long-term opioid use.
Towards an inclusive sufficiency narrative
Authors: Korjonen‐Kuusipuro Kristiina , Koskimäki Teemu , Wojciechowski Adam , Neuvonen Aleksi 
Published: May 2024

In this Editorial, we tackle perhaps the most urgent issue of our time – the need to orient lives more towards sufficiency. Achieving such a transformation also requires a parallel paradigm shift in science. In this Editorial, we have two guest authors, Teemu Koskimäki and Aleksi Neuvonen, who are members of the SISU Consortium doing research on sufficiency transition in Finland.
Schuld als Thema antisemitismuskritischer Bildung. Überlegungen zum Curriculum
Authors: Dubiski Katja 
Published: May 2024

Abstract
Referring to Judith Coffey’s und Vivien Laumann’s monograph »Gojnormativität« the article adapts its embodied main thesis: Talking about »guilt« in German context should be separated from highlighting »antisemitism« in religious education. Analyzing four aspects of guilt - its implicit focus on offenders, its often homogenous idea of »being German«, its idea of powerlessness and of a right to forgiveness - the article turns on discussing cognitive theories having their source in social psychology intergroup theories, that aim at reducing discrimination. Taking the results of both aspects - guilt and (anti-)discrimination - the article concludes with developing ideas for curricula in religious education.
What is Classical Realism?
Authors: Lebow Richard Ned 
Published: May 2024

Abstract
Jonathan Kirshner misrepresents classical realism in fundamental ways. His wants to reclaim classical realism, but he never tells us what it is or engages other scholars who have developed the paradigm. He pleads for a more sophisticated realism but spends much of the book engaging neorealism and ‘hyperrationality.’ He foregrounds Thucydides but reads him superficially and indefensibly in terms of contemporary realist tropes. He asserts – incorrectly – that classical realism eschews abstract formulations but then offers his own. I critique his formulation, reading of Thucydides, and offer an overview of classical realism. I argue that classical realism is an ethical project embedded in a tragic understanding of life. It foregrounds human miscalculations, misjudgments, and their causes, sees tight connections between domestic and foreign policy, and the values that motivate both; and regards great powers as likely to be their own worst enemies.
Two Types of Social Norms
Authors: Burman Åsa 
Published: May 2024

Abstract
In Morality and Socially Constructed Norms, Laura Valentini poses and answers this overall question: When and why, if at all, are socially constructed norms morally binding? Valentini develops an original account, the agency-respect view, that offers an answer to this general question by offering a moral criterion in terms of agency respect. I agree with the criterion proposed by the agency-respect view, given the account of socially constructed norms that it assumes. However, its account of socially constructed norms seems too narrow to answer the general question. More specifically, I argue that the account of social norms is too narrow, even according to Valentini’s own standard, since it does not account for teleological social norms, which are about standards of excellence rather than standards of behavior. Taking teleological social norms into account calls the moral criterion proposed by the agency-respect view into question: it is plausible concerning the type of social norm assumed by the agency-respect view, but not for teleological social norms. Hence, the general question has not been fully answered.
Must I Honor Your Convictions? On Laura Valentini’s Agency-Respect View
Authors: Nieswandt Katharina 
Published: May 2024

Abstract
Laura Valentini’s novel theory, the Agency-Respect View, says that we have a fundamental moral duty to honor other people’s convictions, at least pro tanto and under certain conditions. I raise doubts that such a duty exists indeed and that informative conditions have been specified. The questions that Valentini faces here have a parallel in Kant’s moral philosophy, viz. the question of why one has a duty to value the other’s humanity and the question of how to specify the maxim of one’s action. Additionally, I discuss the concept of a social convention and Valentini’s use of it.
Do Socially Constructed Norms have Moral Force? Précis to a Symposium
Authors: Valentini Laura 
Published: May 2024

Abstract
Do not chew with your mouth open! Take your hat off when you enter a church! Do not skip the queue! Pay your taxes! Do not cross on a red light! These are familiar imperatives, and their immediate source are ‘socially constructed norms’: norms that exist as a matter of social fact. These range from informal etiquette and politeness norms to the complex norms making up our legal systems. While we often feel bound by these norms, we are also aware that they can be pernicious: the product of injustice and vehicles for its perpetuation. The question thus arises: when and why, if ever, does the fact that a socially constructed norm requires us to perform a certain action place us under a genuine moral obligation to comply? In Morality and Socially Constructed Norms, I answer that such an obligation, when it exists, is grounded in a broader, familiar duty, namely the duty to respect people’s permissible and authentic exercises of agency. This is what I call the ‘Agency-Respect View.’ The first part of the book outlines and defends the view, the second part considers relevant applications.
The next decade in accessibility research
Authors: Gerling Kathrin , Rauschenberger Maria , Tannert Benjamin , Weber Gerhard 
Published: May 2024

Abstract
Accessibility research has matured over the last three decades and developed a better understanding of accessibility technologies, design and evaluation methods, systems and tools as well as empirical studies in accessibility. We envision how progress in new contexts over the next decade can be made to develop stronger links to other areas in Human-Centered Computing and address the research communities. A human-centered perspective on disability needs to develop from a medical model to a social model. New methods will utilize generative AI in design and development processes that address accessibility from the start of system design. We build on AI embedded into future design processes to address participation of small numbers of users better, and new technologies to allow for personalization of multi-modal interaction to improve verbal and non-verbal communication, making body-centric computing and natural interaction truly accessible.
Influencing factors of L2 writers’ engagement in an assessment as learning-focused context
Authors: Wang Lu , Shen Bin 
Published: May 2024

Abstract
While prior research on engagement in L2 writing mainly focused on engagement with feedback, little is known about the relationship between engagement and the broader formative assessment context. To fill this gap, this study investigated what and how contextual and individual factors influenced three Chinese undergraduates’ engagement in an assessment as learning (AaL)-focused writing classroom. Drawing on data from interviews, stimulated recalls, classroom observation, and documents, findings indicated that student empowerment, instructional scaffolding, and a teacher-student rapport in an AaL context afforded and motivated students to enact engagement. Meanwhile, sociocultural factors such as beliefs regarding teachers as authorities may constrain students from utilizing learning opportunities. Moreover, when there was an alignment between students’ will and capacity at the individual level, as well as contextual factors at instructional, interpersonal, and sociocultural levels, students were more likely to engage in classroom writing assessment.