bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Prospective Study of the Metabolic Effects of a Low Dose Combined Oral Contraceptive
Authors: Liew Diana F.M. , Ng Charles S.A. , Yong Y.M. , Ratnam S.S. 
Published: August 2010

AbstractThe effects of a low dose combined oral contraceptive (OC) containing 30 μg ethinyl estradiol and 150 μg levonorgestrel, on carbohydrate and lipid metabolism were studied in 39 healthy women. An oral glucose tolerance test (OGGT) was performed before and 6 cycles after OC. Glucose tolerance and insulin response were impaired. There was no change in cholesterol levels. However, triglycerides were significantly lowered but this could be due to the “carry‐over” effects of pregnancy. Body weight was also significantly decreased but was not related to triglyceride change. There was no change in blood pressure after 6 cycles of OC.
Evaluation of Estetrol Metabolism in the Fetoplacental Unit after DHAS Administration to Pregnant Women Near Term
Authors: Sagara Yusuke , Okatani Yuji , Yamanaka Satoshi 
Published: August 2010

AbstractTo assess the significance of measurement of plasma estetrol after dehydro‐epiandrosterone sulfate (DHAS), 100 mg of DHAS was injected 30–60 minutes (7 cases), 120 minutes (6 cases), 180 ‐ 240 minutes (5 cases) before delivery into 18 normal obstetric patients (37–39w) undergoing elective repeat cesarean section. At delivery, maternal peripheral vein (MV), umbilical vein (UV), and umbilical artery (UA) blood and amniotic fluid (AF) were obtained, and unconjugated estetrol in each compartment was measured.A significant increase of plasma estetrol concentration was observed in MV, UV, and UA, with the maximal levels at 180–240 minutes, but not in AF. The increase of plasma estetrol concentrations were higher in UV and UA than in MV. However, no significant difference in the plasma estetrol concentration was seen between UV and UA after DHAS injection. A significant correlation was found between individual MV and UV plasma estetrol concentrations after DHAS injection.The data indicate that determination of a maternal plasma estetrol rise after DHAS injection reflects fetoplacental function and may provide further useful information to evaluate fetal well being.
Etiological Aspects of Ectopic Pregnancy in Nulliparous Women
Authors: Dhall Kamala , Grover Vimal , Mittal Sushil C. , Dhall Gian I. 
Published: August 2010

AbstractThis presentation gives retrospective analysis of 47 cases of ectopic pregnancy in nulliparous women, admitted in the Gynaecological Emergency services of Nehru Hospital attached to the Postgraduate Institute of Medical Education and Research, Chandigarh. Etiological factors leading to ectopic pregnancy in these patients have been presented. Tubal damage in young patients as a result of ascending infections possibly due to sexually transmitted diseases have been discussed. Preventive measures for reducing the incidence of ectopic pregnancy have been emphasized.
Psychosocial Sequelae of Abortion and Sterilization: A Controlled Study of 200 Women Randomly Allocated to Either a Concurrent or Interval Abortion and Sterilization
Authors: Cheng M.C.E. , Cheong June , Ratnam S.S. , Belsey M.A. , Edstrom K.E. , Pinol A. , Zegers L. 
Published: August 2010

AbstractTwo hundred and one women who sought abortion and sterilization were randomly allocated into two study groups to compare the incidence of psychosocial sequelae. The first group (95 patients) had had abortion and concurrent sterilization and the second (106 patients) had abortion followed by interval sterilization 6 weeks later. Of the 106 patients in the second group 74 had the interval sterilization within 3 months. At 12 months between 2 and 3% of women in both groups expressed regret in having the sterilization. There was no difference in the self‐perceived health status of the women in the 2 groups, nor were there any significant differences in perceived changes in menstrual pattern, marital relationships and libido.
Dysgerminoma of the Ovary Associated with Pregnancy
Authors: Kulenthran A. , Sivanesaratnam V. 
Published: August 2010

AbstractTwo cases of dysgerminoma of the ovary associated with pregnancy are presented. The literature on dysgerminoma in pregnancy is reviewed. It is suggested that in young women, with a unilateral well‐encapsulated tumour, a unilateral salpingo‐oophorectomy is the treatment of choice when further childbearing is desired. A more radical surgery is required in those who have completed their family and in those with evidence of capsular infiltration or breach.
Closed Loop Automatic Infusion System for Induction of Labour Based on External Tocography
Authors: Arulkumaran S. , Ingemarsson I. , Ratnam S.S. 
Published: August 2010

AbstractA closed loop automatic infusion system for titrating oxytocin to induce labour based on external tocography was evaluated. Fourty‐one nulliparae and 28 multi‐parae were induced with this system. The obstetric outcome was good with only six caesarean sections; two for fetal distress, two for failed induction and two for malposition and failure to progress. Six nulliparae needed assisted vaginal delivery for prolonged second stage, three due to malposition and three due to poor maternal effort. No multiparae had an instrumental vaginal delivery. Five nulliparae and one multipara with poor cervical score (<=5) were transfered to conventional peristaltic infusion system at the end of nine hours due to failure of progress with clinically inadequate uterine contractions. Of the six, two delivered vaginaily whereas 4 required caesarean section.The neonatal outcome assessed by 1 min and 5 min Agpar scores and umbilical cord arterial pH values was good. The frequency of hypertonic uterine activity was low. With the safety features of alarm and cessation of oxytocin infusion, when uterine hypertonus or abnormal fetal heart rate is encountered, the equipment appears to be an asset for the practice of induction of labour. The adequacy of it's programme for nulliparae with poor score (<=5) has to be further evaluated.
Accuracy of Fetal Weight Estimation by Ultrasound
Authors: Anandakumar C. , Wong Y.C. , Rauff Mary , Ratnam S.S. 
Published: August 2010

AbstractThe main objective of this study was to assess the accuracy of fetal weight estimation by ultrasound. 124 patients were scanned and the estimated fetal weight calculated by the equation of Warsof revised by Shepard was compared with actual fetal weight of the newborns, who were born within one week of the last scan. In 93.3% of the time the estimated weight by ultrasound was within 15% of the actual weight.
Treatment of Drug‐Tolerant Choriocarcinoma in Combination with Bleomycin, Cisplatin and VP16‐213 (Etoposide)
Authors: Yamamoto Takara , Shiroshita Kohe , Tsuji Masamichi , Okada Hiroji 
Published: August 2010

AbstractA 38‐year‐old patient with choriocarcinoma who was tolerant to MTX and Act‐D and highly refractory to MECA therapy after hysterectomy and bilateral oophorec‐tomy was treated with 4 courses of BCE therapy. One course of BCE therapy consisted of bleomycin (Bleo Inj.®, Nihon Kayaku Co., Ltd., Tokyo Japan. Day 1–5: 5 mg i.v. infusion/day); cisplatin (Briplatin®, Bristol‐Myers Co., Ltd., Tokyo, Japan. Day 1; 50 mg i.v. infusion/m2); and VP16‐213, (Etoposide, Day 1–5: 100 mg i.v. infusion/m2 /day). This treatment was successful in achieving complete remission.
The Clinical Significance of Antibody against Oncofetal Antigen‐I (anti‐OFA‐I) in Patients with Gynecologic Tumors
Authors: Higuchi Masaomi , Takahashi Masaaki , Takeuchi Yutaka , Hando Tamotsu , Takeuchi Shoshichi 
Published: August 2010

AbstractOncofetal antigen‐I (OFA‐I) is a membrane antigen of human cancer cells that cross‐reacts with human fetal brain tissues. The antibody profile against this antigen was analyzed in relation to the course of disease.Fifteen out of 22 patients had persistently stable antibody levels and antibody titer in three of them increased by more than 4‐fold. These patients did not show either recurrence or death, but had a good prognosis. In four patients, antibody levels dropped by more than 4‐fold and was followed by clinical recurrence and death.These studies show that persistently stable antibody titers are predictive of non‐recurrence, and decreasing titers predictive of recurrence.
Maternal Serum Cholinesterase Levels in Pregnant Women in Healthy and Diseased States
Authors: Satyanarayana M. 
Published: August 2010

AbstractMaternal serum cholinesterase estimation was done in pregnant women in gesta‐tional‐wise, during labour and pathological states by spectrophotometric method. Sera from non‐pregnant women was used as controls (190 units/ml). During normal pregnancy, cholinesterase levels in maternal serum increased abruptly from 8 weeks (220 units/ml) to 20 weeks (380 units/ml) and fell gradually to low levels (210 units/ ml) at <42 weeks (post‐mature pregnancy). Serum cholinesterase levels were significantly increased during second and third stage of labour. In the post partum period, serum cholinesterase levels in the maternal blood rapidly reached the non‐pregnant levels (180 units/ml) by 2nd day after delivery. Significant variation of maternal serum cholinesterase levels were found in pregnancy with patients undergoing induced abortions, cases of threatened abortions, congenital anomalies of foetus, pre‐eclampsia, eclampsia, nephrotic syndrome, tuberculosis, infectious hepatitis, anaemia, diabetes mellitus, Rh‐incompatibility, placenta praevia, etc. These observations may have an important bearing because this may lead to a better understanding of serum cholinesterase's basic biochemical function and application in clinical medicine.
Differential Diagnosis of Intraperitoneal Fluid by Ultrasound
Authors: Murao Fuminori , Hata Kohkichi , Hata Toshiyuki , Shibukawa Toshihiko , Iwanari Osamu , Kitao Manabu 
Published: August 2010

AbstractA review of 40 clinical cases of proven intraperitoneal fluid was made to assess the accuracy of ultrasonography for diagnosing the nature or distribution of intraperitoneal fluid and for differentiation between fluid collection and other conditions.Since the distributions of intraperitoneal fluid depend on the action of gravity, capillary attraction, adhesion and so forth, localized fluid collection or unusual distribution of fluid poses a problem in differential diagnosis. An unusual or irregular collection of fluid may suggest a malignant ascites.Deviations from a homogenous, echo‐free space suggest an inflammatory, mucinous or malignant fluid.The smallest amount of fluid identified by ultrasound was thought to be approximately 10 ml.
Steroid Receptors and Histological Types in Cervical Cancer
Authors: Fujimoto Jiro , Tamaya Teruhiko , Watanabe Yoshinobu , Arahori Kenji , Sato Sohei , Okada Hiroji 
Published: August 2010

AbstractEstrogen receptor (ER), progestin receptor (PR), and androgen receptor (AR) levels in cytosol, nuclear KC1 extract, and nuclear KC1 unextractable fraction were determined in 34 cases by Scatchard analyses, using the dextran‐coated charcoal (DCC) method for the first two receptors and the washing method for the last one. The dissociation constants of ER, PR and AR ranged from 10‐10 to 10‐9 M. The histological types were classified according to the World Health Organization criteria. ER, PR and AR were detected in some cases of cancer of the cervix. Regardless of the histological types of squamous cell carcinoma of the cervix, ER was detected in almost all cases. The detection rate of PR (8/27) was significantly lower (p<0.03) than that of ER (25/ 27), and that of AR (16/27) tended to be lower (p<0.09) than that of ER (25/27) in large cell non‐keratinizing carcinoma, keratinizing carcinoma, and small cell non‐keratinizing carcinoma. PR was not detected in cases of cervical adenocarcinoma, regardless of their histological differentiation.
Steroid Sulfatase Deficiency: Enzymatic Studies Using Placenta and Leucocytes in One Family
Authors: Sakai Sumitaka , Honda Hiroshi , Kawai Nobuhide , Sakurai Norio , Arimoto Kiyoshi 
Published: August 2010

AbstractVarious placcntal and leucocyte enzyme activities were determined in a male newborn whose mother had decreased urinary E3 and serum total E3 levels during the course of pregnancy, suggesting placental sulfatase deficiency (PSD). Tests revealed that both placental steroid sulfatase (SS) and arylsulfatase C (ASC) were deficient but arylsulfatases A and 15 were normal. SS activity, as well as the levels of arylsulfatases A, B and C, were also determined in the newborn and his family members using leucocytes. SS and ASC activities were deficient in the newborn and one of his male cousins. Both cases had cutaneous ichthyosis several weeks after birth. Leucocyte SS and ASC activities in the mother and grandmother of these two cases with steroid sulfatase deficiency (SSD) were 38% to 69% of the mean levels in the control. This, coupled with the results of the family investigation, strongly suggests that the deficiency is a sex‐linked recessive hereditary condition. Control values for SS and ASC were higher in females than in males. These results indicate that the diagnosis of SSD and the screening of carriers can be made using both leucocytic SS and ASC activities. Estrogen E1, E2 and E3 levels were low in maternal and umbilical cord blood.
Cytological Properties of Human Ovarian Carcinoma Cell Lines
Authors: Ishiwata Isamu , Ishiwata Chieko , Nozawa Shiro , Ishikawa Hiroshi 
Published: August 2010

AbstractOvarian carcinomas from 30 cases were cultured, and 8 cell lines, including 4 lines of serous cystadenocarcinoma (SCAC), 2 lines of endometrioid adenocarcinoma (EAC), one line of anaplastic carcinoma (AC), and one line of clear cell carcinoma (CCC), were established. Examination of the cytobiological properties (morphology, proliferation, chromosomes, heterotransplantability, etc.) of the cell lines revealed that the cell lines maintain the characteristics of the original tumor in vitro for a long period. HTOA and HUOA, both SCAC lines of a well differentiated type, produce a large amount of CA125 and formed SCACs that were extremely similar to the original tumor in nude mice. HTBOA (AC line) and HUOCA‐II (CCC line, poorly differentiated type) were both easy to transplant to nude mice, and the tumor formed was rich in blood vessels, proliferated rapidly, and showed histology that was similar to that of the original tumor. The HTBOA cells produced granulocyte colony‐stimulating‐factor (G‐CSF) and caused granulocytosis in the mouse.
Plasma Gastrin and Secretin in Neonates
Authors: Nakai Toshiaki , Yamada Ritsuji , Watanabe Hiroshi , Kumasaka Takahiro 
Published: August 2010

AbstractWith a view to investigating the dynamics of gastrointestinal hormones after birth, chronological changes in gastrin and secretin in the blood after birth were determined with radioimmunoassay. At delivery, the gastrin concentration in the umbilical cord plasma was 201 ±10 pg/ml (mean±SEM), significantly higher than that in the maternal vein. In the first 4–48 hours of life, it decreased to the adult level and rose again at 5 days of age. Next, the post‐prandial gastrin responses in both neonates and adults were examined. Percent increase in neonatal plasma gastrin concentration after feeding, as compared with the pre‐feeding level, was significantly higher than that observed in the adults. From these findings, we presumed that the “release setting” of gut endocrine cells differs between neonates and adults and also that enteral feeding might trigger the postnatal increase in the plasma gastrin concentration. The secretin concentration in the arterial cord plasma was 314 ±22 pg/ml. The secretin concentration in the blood also decreased in the first –8 hours of life, this decrease being similar to that of the gastrin level. However, a second rise in the level, as in the case of gastrin, was not observed at 5 days of age. In milk‐fed neonates, secretin did not show a postprandial response as did gastrin.
Diagnoses and Prognoses of Fetal Cardiovascular Anomalies in utero, Assessed Echocardiographically
Authors: Hara Kenji , Koyanagi Takashi , Hori Eiichi , Satoh Shoji , Nakano Hitoo 
Published: August 2010

AbstractThis echocardiographic study was designed to determine the accuracy of prenatal diagnoses of fetuses with cardiac anomalies and also to evaluate the manner in which various types of disorders affect the prognoses in utero. In 13 fetuses studied, the following cardiac anomalies were present: ventricular septal defect (VSD), atrial septal defect (ASD), atrio‐ventricular septal defect (AVSD), double outlet of the right ventricle, hypoplastic right (HPRV) and left (HPLV) ventricles, Ebstein's anomaly, endocardial fibroelastosis (EFE), transposition of the great arteries, coarctation of the aorta and cardiac tumor.These were categorized by the minimum unit of cardiovascular anomalies. According to this criteria, the correct, false positive, false negative, and misinterpretations were estimated to be 71.4, 4.8, 14.3 and 9.5%, respectively. After division of correctly diagnosed cases into 2 groups, 86.7% of heart anomalies and 50.0% of those of great vessels were found to be accurately diagnosed.Fetal prognoses with cardiovascular anomalies were classified into 3 groups: cardiac failure, intrauterine growth retardation and no sequelae.The first group was representative of EFE and HPRV, the second group, representative of hypoplastic ventricle and deffective heart diseases complicated by chromosome anomalies or other major malformations. The third group included all anomalies but with no sequelae in utero.
Pelvic Outlet Contraction: A Forgotten Entity
Authors: Fliegner John R. H. 
Published: August 2010

AbstractPelvic outlet contraction is rare, but should be readily diagnosed at the routine assessment of the pelvis during the prenatal period. When in doubt, accurate measurements of the bony outlet by X‐ray pelvimetry are mandatory. A trial of labor is not applicable if the pelvic outlet is reduced, because the true state of disproportion will not be appreciated until very late in labor. A case is reported in which severe outlet contraction was not recognized in the prenatal period, and only became evident after fetal distress necessitated careful assessment in labor.
Nonimmunologic Hydrops Fetalis and Chromosome Aberration
Authors: Maeda Hirotaka , Shimokawa Hiroshi , Matsuo Toshiko , Hisanaga Sachio , Nakano Hitoo 
Published: August 2010

AbstractIn order to evaluate the role of genetic amniocentesis for the management of nonimmunologic hydrops fetalis (NIHF), the present study was performed.In 29 cases with NIHF, diagnosed antenatally using ultrasound, a genetic amniocentesis was performed. Three cases had chromosome aberration and all were 21 trisomy; one had a heart anomaly and the other 2 cases had no malformations. All 3 cases died during the neonatal period in spite of intensive perinatal management. Among NIHF, the incidence of 21 trisomy is 10%.Genetic amniocentesis is an invaluable means to detect underlying diseases in NIHF.
Effect of Various C19‐Steroids upon the Production of Progesterone and 17α‐Hydroxyprogesterone by Preovulatory Hamster Follicles in Culture
Authors: Matson Phillip L. , Collins William P. 
Published: August 2010

AbstractPreovulatory follicles (591–740 μm) were isolated from immature golden hamsters 72–78 h after the administration of 40 IU PMSG and cultured for 4 h in the presence or absence of androstenedione, dehydroepiandrosterone, testosterone or 5α‐dihydrotes‐tosterone. Dose‐dependent increases in the output of progesterone and 17α‐hydroxy‐progesterone were caused by each of the C19‐steroids tested and this stimulation was not dependent upon the synthesis of new mRNA or protein.
Recent Changes in the Epidemiology of GTN in Taiwan, ROC: Preliminary Report
Authors: Hsu Chien‐Tien , Jong Hong‐Lin , Wang Tai‐Te , Chang Chung‐Chuan , Roan Cheng‐Hsiung , Lin Yun‐Nan , Chen Ting‐Yao , Lan Chung‐Fu 
Published: August 2010

AbstractFour hundred and seventy‐four cases of GTN from the Municipal Chunghsing Hospital, the Municipal Maternal and Child Hospital, the Department of Pathology of Taipei Medical College and MacKay Memorial Hospital were collected and statistically analyzed. The present study proves that hospital statistics on the incidence of GTN were inadequate, being subject to change according to the number of hospital deliveries which could be dependent on the socioeconomic status and educational level of the community. There is a highly significant positive correlation between the incidence of GTN and the fertility rate, but no correlation with the total number of live births. There was a highly significant negative correlation between the incidence of GTN and the per capita daily consumption of protein (r = ‐0.7189), calorie intake (r = ‐0.6332) and per capita income (r = ‐0.8420). The gradual decrease of GTN in an earlier period and the acute drop in GTN incidence in the last 10 years reflects Taiwan's progress from the status of a developing country to that of a developed country. The close parallelism between the incidence of GTN (or relative incidence; the percentage of GTN among the total of all surgical specimens) and the fertility rate reflects the Taiwan's successful family planning program. In particular the sharp divergence between the fertility rate and the total number of live birth more definitely indicates the success.Epidemiological studies would suggest that contrary to reports in the literature, there may be no great difference in the incidence of GTN in China and the USA. Socioeconomic and environmental (nutritional and life style) factors might play a more important role than the racial factor.
Measurement of Placental Blood Flow by the Thermocouple Method in Comparison with the Electromagnetic Flowmeter Method
Authors: Hidaka Atsuo , Komatani Mitsuo , Sugawa Tadashi 
Published: August 2010

AbstractA comparative study of flow measurements in model experiment by using a thermocouple method and an electromagnetic flowmeter was done, with the result that the flow waves shown by both apparatuses were seen to be quite analogous.Furthermore, the influence of uterine artery occlusion on placental blood flow was studied using the thermocouple method in comparison with measuring blood flow in a uterine artery by using an electromagnetic flowmeter in 5 late pregnant dogs. Both flows revealed almost the same pattern, however, the placental blood flow changes were more gradual than that of the uterine arterial blood flow.We found that the thermocouple method is useful to measure placental blood flow on the maternal side.
Fetal Cardiac Hemodynamics Assessed by Two‐Dimensional Doppler Echocardiography
Authors: Hata Toshiyuki , Hata Kohkichi , Ryukoh Kanji , Aoki Showa , Takamori Hisazumi , Nagata Hiroko , Nishigaki Arata , Hirayama Keiko , Takamiya Osamu , Murao Fuminori , Kitao Manabu 
Published: August 2010

AbstractForty‐one 2‐dimensional (2‐D) Doppler echocardiographic examinations were performed on 36 fetuses in utero, at 17 to 39 weeks of gestation. Left and right transvalvular, aortic, pulmonary, transforaminal, and inferior vena caval flows were assessed. The rates of detection of left and right transvalvular, aortic, pulmonary, transforaminal, and inferior vena caval flows were 85.4, 73.2, 53.7, 41.5, and 9.8%, respectively. In one fetus with premature atrial contraction, there was a characteristic pattern of intracardiac hemodynamics. The 2‐D Doppler echocardiography is proving to be very useful for assessing in utero fetal cardiac hemodynamics and determining related physiologic and pathologic states.