bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction of resistance to bevacizumab plus FOLFOX in metastatic colorectal cancer—Results of the prospective multicenter PERMAD trial
Authors: Seufferlein Thomas , Lausser Ludwig , Stein Alexander , Arnold Dirk , Prager Gerald , Kasper-Virchow Stefan , Niedermeier Michael , Müller Lothar , Kubicka Stefan , König Alexander , Büchner-Steudel Petra , Wille Kai , Berger Andreas W. , Kestler Angelika M. R. , Kraus Johann M. , Werle Silke D. , Perkhofer Lukas , Ettrich Thomas J. , Kestler Hans A. 
Published: June 2024

Background
Anti-vascular endothelial growth factor (VEGF) monoclonal antibodies (mAbs) are widely used for tumor treatment, including metastatic colorectal cancer (mCRC). So far, there are no biomarkers that reliably predict resistance to anti-VEGF mAbs like bevacizumab. A biomarker-guided strategy for early and accurate assessment of resistance could avoid the use of non-effective treatment and improve patient outcomes. We hypothesized that repeated analysis of multiple cytokines and angiogenic growth factors (CAFs) before and during treatment using machine learning could provide an accurate and earlier, i.e., 100 days before conventional radiologic staging, prediction of resistance to first-line mCRC treatment with FOLFOX plus bevacizumab.

Patients and methods
15 German and Austrian centers prospectively recruited 50 mCRC patients receiving FOLFOX plus bevacizumab as first-line treatment. Plasma samples were collected every two weeks until radiologic progression (RECIST 1.1) as determined by CT scans performed every 2 months. 102 pre-selected CAFs were centrally analyzed using a cytokine multiplex assay (Luminex, Myriad RBM).

Results
Using random forests, we developed a predictive machine learning model that discriminated between the situations of “no progress within 100 days before radiological progress” and “progress within 100 days before radiological progress”. We could further identify a combination of ten out of the 102 CAF markers, which fulfilled this task with 78.2% accuracy, 71.8% sensitivity, and 82.5% specificity.

Conclusions
We identified a CAF marker combination that indicates treatment resistance to FOLFOX plus bevacizumab in patients with mCRC within 100 days prior to radiologic progress.
Disparities in COVID-19 vaccine intentions, testing and trusted sources by household language for children with medical complexity
Authors: Chen Laura P. , Singh-Verdeflor Kristina , Kelly Michelle M. , Sklansky Daniel J. , Shadman Kristin A. , Edmonson M. Bruce , Zhao Qianqian , DeMuri Gregory P. , Coller Ryan J. 
Published: June 2024

Objectives
Children with medical complexity experienced health disparities during the coronavirus disease 2019 (COVID-19) pandemic. Language may compound these disparities since people speaking languages other than English (LOE) also experienced worse COVID-19 outcomes. Our objective was to investigate associations between household language for children with medical complexity and caregiver COVID-19 vaccine intentions, testing knowledge, and trusted sources of information.

Methods
This cross-sectional survey of caregivers of children with medical complexity ages 5 to 17 years was conducted from April-June 2022. Children with medical complexity had at least 1 Complex Chronic Condition. Households were considered LOE if they reported speaking any language other than English. Multivariable logistic regression examined associations between LOE and COVID-19 vaccine intentions, interpretation of COVID-19 test results, and trusted sources of information.

Results
We included 1,338 caregivers of children with medical complexity (49% response rate), of which 133 (10%) had household LOE (31 total languages, 58% being Spanish). There was no association between household LOE and caregiver COVID-19 vaccine intentions. Caregivers in households with LOE had similar interpretations of positive COVID-19 test results, but significantly different interpretations of negative results. Odds of interpreting a negative test as expected (meaning the child does not have COVID-19 now or can still get the virus from others) were lower in LOE households (aOR [95% CI]: 0.56 [0.34–0.95]). Households with LOE were more likely to report trusting the US government to provide COVID-19 information (aOR [95% CI]: 1.86 [1.24–2.81]).

Conclusion
Differences in COVID-19 test interpretations based on household language for children with medical complexity were observed and could contribute to disparities in outcomes. Opportunities for more inclusive public health messaging likely exist.
Chasing the Bounty: The Voyages of the Pandora and the Matavy, Donald A. Maxton (ed.) (2020)
Authors: Lansdown Richard 
Published: June 2024

Review of: Chasing the Bounty: The Voyages of the Pandora and the Matavy, Donald A. Maxton (ed.) (2020)
Jefferson, NC: McFarland, 200 pp.,
ISBN 978 1 47667 938 9 (pbk), US$39.95
Policy-making under Pressure: Rethinking the Policy Process in Aotearoa New Zealand, Sonia Mazey and Jeremy Richardson (eds) (2021)
Authors: Prior Martin 
Published: June 2024

Review of: Policy-making under Pressure: Rethinking the Policy Process in Aotearoa New Zealand, Sonia Mazey and Jeremy Richardson (eds) (2021)
Christchurch: Canterbury University Press, 316 pp.,
ISBN 978 1 98850 324 0 (pbk), NZ$49.99
A method for fast detection of wind farms from remote sensing images using deep learning and geospatial analysis
Authors: Chen Deliang , Cheng Taotao , Lu Yanyan , Xiao Jianbo , Ji Chen , Hong Siyu , Zhuang Qizhi , Cheng Liang 
Published: June 2024

Abstract
The wind power industry is increasing worldwide every year. Thus, obtaining timely and detailed information on wind farms’ number and spatial distribution is critical for quantitatively estimating wind energy utilization and for planning the construction of new wind farms. Therefore, this study proposes a method for quickly identifying wind farms in a large-scale area. Given that wind farms mainly comprise individual objects such as wind turbines and substations, we labeled sample images of wind turbines and substations on a global scale. Then, these sample images are used to train a target recognition model and an object classification model and detect the specific locations of wind turbines and substations in the study area. Additionally, we deeply analyzed the location features of the wind turbines and further improved the recognition accuracy based on these known features using geographic constraints. Based on the location information of wind turbines and substations, a clustering model organizes them effectively into complete wind farms. A comprehensive evaluation of the clustering model verifies its scientific validity and reliability. Specifically, this framework was systematically tested throughout Vietnam with remarkable results, using high-resolution historical images provided by Google Earth. Indeed, our framework achieved 90.45% recall and 95.73% accuracy for wind turbines and 81.37% recall and 78.96% accuracy for substations. Finally, we successfully obtained the spatial location and distribution of 15 completed wind farms, demonstrating that the proposed scheme can quickly and accurately identify wind power plants in a large-scale area, which supports wind power management and energy utilization planning.
Staatshaftung für fehlerhafte Finanzmarktaufsicht
Authors: Cornils Matthias , Gurlit Elke 
Published: June 2024

Zusammenfassung
Im Gefolge des Wirecard-Skandals sind die seit Jahrzehnten geführten Diskussionen um den Ausschluss der BaFin von der Amtshaftung wieder aufgeflammt. Der Beitrag analysiert, ob und inwieweit einleger- und anlegerschützende Amtspflichten der Bundesanstalt durch § 4 Abs. 4 FinDAG haftungsrechtlich sanktionslos gestellt werden. Er untersucht zudem die Vereinbarkeit eines derartigen Haftungsausschlusses mit den Vorgaben des Unions- und Verfassungsrechts.
Die Veröffentlichung der Eigengeschäfte von Führungskräften
Authors: Hellgardt Alexander , Herrnberger Johannes 
Published: June 2024

Zusammenfassung
Führungskräfte von Emittenten und ihnen nahestehende natürliche und juristische Personen müssen Eigengeschäfte in Finanzinstrumenten des Emittenten nach Art. 19 MAR melden. Der Veröffentlichung dieser Meldungen werden im juristischen Diskurs viele wichtige Funktionen für die Funktionsfähigkeit des Kapitalmarkts zugeschrieben. Die vorliegende Studie ist die erste, die eine Langzeitanalyse der tatsächlich am deutschen Kapitalmarkt veröffentlichten Meldungen vornimmt.
Interacción genotipo/ambiente y estabilidad del rendimiento en líneas avanzadas de ají Topito (Capsicum chinense)
Authors: Muñoz-Falcon Julio Ernesto , Correa-Álvarez Ender Manuel , León-Pacheco Rommel Igor , Silva-Acosta Gabriel Ernesto , Yacomelo-Hernández Marlon José , Florez-Cordero Elias David 
Published: June 2024

Introducción. El ají dulce tipo topito (Capsicum chinense Jacq, sinense Murray) es un cultivo tradicional de la región Caribe de Colombia, el cual ocupa el tercer lugar entre las hortalizas sembradas en esta zona del país. Objetivo. Evaluar la interacción genotipo x ambiente y la estabilidad del rendimiento en nueve líneas avanzadas de ají dulce tipo Topito obtenidas en el programa de mejoramiento genético de hortalizas de la Corporación Colombiana de Investigación Agropecuaria (AGROSAVIA). Materiales y Métodos. En el año 2020 se establecieron cuatro ensayos de evaluación agronómica en las localidades de San Pelayo, Córdoba; Sincelejo, Sucre; Suan, Atlántico y Zona Bananera, Magdalena, todas ubicadas en la región caribe de Colombia. Para los experimentos se empleó un diseño de bloques completos al azar con cuatro repeticiones. Las variables respuesta fueron: el rendimiento, el número de frutos por planta, el peso fresco del fruto y la longitud del fruto. Se realizaron análisis de estabilidad fenotípica del rendimiento mediante los métodos propuestos por Eberhart y Russell y Lin y Binns. Resultados. Hubo interacción genotipo ambiente significativa para variables asociadas al rendimiento de fruto. Mediante el análisis del comportamiento productivo de los materiales en los diferentes ambientes, se pudieron identificar las líneas L61 y L7 como genotipos sobresalientes con rendimientos estadísticamente superiores (P≤0,05) al testigo regional utilizado y con características de fruto acordes a los requerimientos del mercado de consumo fresco regional. Conclusiones. Los genotipos L61 y L7 fueron los que presentaron mejor adaptación a los diferentes ambientes evaluados y mayor potencial productivo, el ambiente Zona Bananera fue donde se alcanzó los mayores rendimientos con 59,11 t ha-1 para L61 y con 55,05 t ha-1 para la línea 7.
ИССЛЕДОВАНИЕ И РАЗРАБОТКА ИНФОРМАЦИОННОЙ СИСТЕМЫ АНАЛИЗА И ЗАГРУЗКИ ДАННЫХ ПРИ ПОМОЩИ НЕЧЕТКОГО СРАВНЕНИЯ СТРОК
Authors: Яхонтова Ирина Михайловна , Нилова Надежда Михайловна 
Published: June 2024

Предмет: нечеткое сравнение строк, или просто неточное сравнение – это процесс поиска похожих, но необязательно в точности совпадающих строк. Сущность использования методов нечеткого сравнения строк на предприятии заключается в предоставлении возможности эффективной загрузки данных первичных документов в учетную систему предприятия. Цель: современные требования к развитию бизнеса достаточно высоки с точки зрения организации электронного документооборота. Статья посвящена исследованию математических методов сопоставления текстовых строк и разработке методики анализа и загрузки данных в информационную систему предприятия. Дизайн исследования: поступающие первичные документы, вне зависимости от стандартности их оформления, должны быть загружены в учетную систему предприятия на первоначальном этапе. Такой подход позволит соблюдать принцип фиксирования информации у источника, а также повысить эффективность документооборота в целом за счет ускорения получения данных из документов всеми службами предприятия. Существует большое количество методов анализа текстовых фрагментов, однако наиболее эффективными из них считаются методы нечеткого сравнения строк. Таким образом, применение научного подхода при выполнении операций загрузки данных позволит обеспечить безошибочность и скорость данного процесса. Результаты: в результате проведенного исследования было выявлено, что повышение экономической эффективности учетных процессов предприятия напрямую зависит от скорости и безошибочности загрузки данных из первичной документации в информационную систему предприятия. Была разработана методика анализа и загрузки данных при помощи методик нечеткого сравнения строк.
ИССЛЕДОВАНИЕ ОПЫТА КИТАЯ В ОБЛАСТИ ЗАЩИТЫ ПРАВ ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ НА ПЛАТФОРМАХ ЭЛЕКТРОННОЙ КОММЕРЦИИ С ПРЯМЫМИ ТРАНСЛЯЦИЯМИ
Authors: ПОКРОВСКАЯ Анна Владимировна 
Published: June 2024

В статье исследован опыта Китая в области защиты прав интеллектуальной собственности (ИС) на платформах электронной коммерции с прямыми трансляциями. Растущая популярность электронной коммерции и повышение значимости цифрового контента создают новые вызовы в области защиты интеллектуальной собственности. Китай как одна из ведущих экономических держав имеет значительный опыт в этой области. В статье рассмотрены законодательные и нормативные акты, принятые Китаем для обеспечения защиты прав ИС на платформах электронной коммерции с прямыми трансляциями. Проанализировано применение таких мер, как обязанности платформы по контролю контента, мониторингу нарушений, удалению нарушающего контента и сотрудничеству с правообладателями. Особое внимание уделено эффективности принятых мер и их влиянию на снижение числа нарушений прав ИС.
Изучена судебная практика и решения судов, связанные с нарушением прав ИС на платформах электронной коммерции с прямыми трансляциями в Китае. Описано дело компании Saishi Trading (Shanghai) Co., Ltd. (Saishi) против Hongyu и Bytedance. Проанализированы законы и нормативные акты об интеллектуальной собственности, относящиеся кпрямой трансляции, правовой статус электронной коммерции в прямом эфире, механизмы защиты прав ИС.
Результаты исследования дают возможность сделать выводы о положительных и отрицательных аспектах опыта Китая в области защиты прав ИС на платформах электронной коммерции с прямыми трансляциями. Это позволяет выявить перспективы и сформулироватьрекомендации для других стран, которые сталкиваются с подобными вызовами и стремятся разработать эффективные меры защиты прав ИС в сфере электронной коммерции.
Single-Station Multiparametric Seismic Monitoring of Copahue Volcano, Argentina–Chile (2018–2023)
Authors: Casas José Augusto , Badi Gabriela Alejandra , Mikesell Thomas Dylan , Garcia Sebastian Esteban , Draganov Deyan 
Published: June 2024

Abstract
Knowledge about the temporal evolution of a volcano is fundamental for an accurate understanding of the occurring physical dynamic processes and an appropriate assessment of the most probable near-future volcanic scenarios. Using seismic data recorded in the area of one of the most hazardous volcanoes along the Argentina–Chile, international border—Copahue volcano, we obtain information for an improved interpretation of the processes that occurred before, during, and after eruptive events. We use a single-station methodology to assess variations in the mechanical properties and internal structure of the Copahue volcano. Thus, we obtain information about structural alterations, friction and fractures, and variations in rigidity in the volcanic system. Our results show that the time variations of the evaluated seismic parameters correlate to the volcanic phenomena observed on the surface, that is, incandescence and ash emissions. Accounting for the physical processes, to which the analyzed seismic parameters are sensitive, and previous models developed for the area, we propose a physical model explaining the eruptive events that occurred at Copahue in the period 2018–2023. This model can potentially be used for the assessment of future scenarios, which is of fundamental importance for the institutions in charge of the real-time monitoring of Copahue volcano to improve the quality of their evidence-based decisions.
Navigating Challenges: Exploring Challenges to Occupational Diversification Amongst the Farmers in Odisha
Authors: Jayasingh Debi Kalyan , Mishra Bishnupriya , Behera Kamalakanta , Pattanaik Subrat 
Published: June 2024

Background: Growing uncertainties in farm-related endeavours have prompted concerns about the sustainability of farming communities, leading occupational diversification. Farmers were quite perceptive about the advantages of diversification yet they still fail to derive the benefits of it at the optimum extent in the form of the addition to the existing earning levels. That is why, this context pre-requisites of assessing the existing levels of occupational diversification and to determine the issues that ceasing the progress of farmers in the ventures of diversification. Methods: The study was conducted in Khordha district of Odisha state under ex-post facto research design. A sample of 240 farmers was undertaken from eight villages through multi-stage random sampling procedure. Data collection conducted by personal interview with the use of pre-tested semi-structured questionnaires. Simpson’s index of diversification for assessing occupational diversification along with Henry Garrett’s ranking for grading the constraints faced by farmers were employed in the study. Result: Majority (47.50%) of the farmers expressed moderate level in terms of extent of occupational diversification. The top ranked constraints under each dimension found to be- shortage of storage facilities (74.77) and marketing facilities (71.34) under infrastructural; absence of innovative technologies (73.55) and lack of market forecasting (70.11) under promotional; lack of proper education (72.23) and less experience on new ventures (70.79) under social; shortage of own resources (69.33) and rising fuel prices (65.33) under economic; erratic rainfall (70.77) and natural disturbances like floods, cyclones, etc. (64.46) under miscellaneous dimension. Therefore, the investigation recommends that the focusing on the solution-oriented approach towards the above-mentioned constraints for augmenting occupational diversification.
Algorithms for Creating the Digital Archive of the Regional Architectural Heritage
Authors: Ved E. A. 
Published: June 2024

The library aims at preserving evidence of the past, creating, classifying and systemizing digital copies of cultural and historical objects as well. The purpose of the article is to present the model of the digital archive of scanned documents organized by Gomel regional universal library. The archive of electronic images of documents is proposed to be organized in accordance with the concept of the State archival institution, and digital copies are to be museumized; the description of such documents should contain symbols indicating its digital nature. The proposed model of the digital archive can become the tool for accounting and storing documents, the search system, oriented toward satisfaction of specialists’ information requests and the possible platform model for to create the regional repository of the historical and cultural heritage.
Oxidative Stress and Symptoms Associated with Multiple Sclerosis.
Authors: Piñar-Morales Raquel , Duran-Ogalla Raquel , Bautista Alicia , Garcia Maria Jose , Aliaga-Gaspar Pablo , Vives-Montero Francisco , Barrero-Hernández Francisco J 
Published: June 2024

Abstract

Multiple sclerosis (MS) is a chronic, inflammatory and degenerative disease that affects the central nervous system with an unknown pathophysiology. Oxidative stress appears to play a prominent role in both the onset of the disease as well as the perpetuation of the inflammatory and neurodegenerative process. We have analysed parameters relating to oxidative stress in people with multiple sclerosis (pwMS) and healthy people. In pwMS, the ratio of oxidative stress was determined using clinical and neuroimaging variables. Superoxide dismutase (SOD) activity was higher in pwMS compared to the control group, while the total antioxidant capacity (TAC), 4-hydroxynonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8 OH-dG) were lower in pwMS. The TAC levels correlated with age and the time of evolution. The pwMS with a slowing down in the speed of processing exhibited lower levels of TAC and greater levels of 4-HNE. No relationship was found between oxidative stress and the presence of depression, fatigue or a lower quality of life. The results suggest that the mechanisms involved in the cognitive impairment (CI) observed in MS may be related to oxidative stress, which is why these parameters could be useful in diagnosis and monitoring.
Activities of the dorsolateral and medial prefrontal cortices during oral function training: an NIRS study
Authors: Abe Masumi , Nouchi Rui , Ogawa Toru , Shiraishi Naru , Hihara Hiroki , Sasaki Keiichi , Yoda Nobuhiro 
Published: June 2024

Abstract

Background
Cognitive function plays a crucial role in human life, and its maintenance and improvement are essential in both young and older adults. Since cognitive decline can be associated with oral function decline, preventing the decline in both cognitive and oral functions is an urgent social issue. Several training methods to improve each function have been proposed. Previous studies have indicated that greater brain activity during training is associated with increased benefits for cognitive function. Although adding cognitive function elements to oral function training may promote the activation of brain activity during oral function training, the effects have not been validated. This study aimed to develop a novel training program that combines oral function training with cognitive training, which is expected to activate key brain regions involved in oral and cognitive functions, such as the left dorsolateral prefrontal cortex (DLPFC) and right medial prefrontal cortex (mPFC).
Methods
Four types of training programs combining oral and cognitive training: PaTaKaRa × calculation, lip exercise × N-back, tongue exercise × inhibition, and tongue exercise × memory, were developed. Each program had seven levels of difficulty [level 0 (no cognitive load) and level 6 (maximum difficulty)]. Twelve healthy young adults participated in the study and were instructed to perform all four programs. Brain activity in the left DLPFC and right mPFC were measured during each training session using two-channel near-infrared spectroscopy (NIRS).
Results
No significant brain activity was observed during training at level 0. Brain activity in the left DLPFC was significantly increased at levels 1 and 2 and in the left DLPFC and right mPFC at level 6 during PaTaKaRa × calculation training. Brain activity in the left DLPFC was significantly increased at level 6 during tongue exercise × inhibition training. Brain activity in the left DLPFC and right mPFC was significantly increased at level 6 during lip exercise × N-back training.
Conclusion
Oral function training did not significantly increase brain activity; nevertheless, oral function with cognitive training stimulated brain activity in the prefrontal cortex.
Trial registration
UMIN-CTR. ID: UMIN000039678. date: 06/03/2020