bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared decision-making in psoriasis care: Evaluation of how patients’ perception of clinicians’ delivery of care changes by age and sex
Authors: Kikuchi Robin , Kingston Paige , Hao Audrey , Sadrolashrafi Kaviyon , Yamamoto Rebecca K. , Tolson Hannah , Bilimoria Sara N. , Guo Lily , Yee Danielle , Ochoa Maria T. , Armstrong April W. 
Published: May 2024

Background
Shared decision-making (SDM) refers to a collaborative process in which clinicians assist patients in making medically informed, evidence-based decisions that align with their values and preferences. There is a paucity of literature on SDM in dermatology.

Objective
We aim to assess whether male and female psoriasis patients evaluate their clinicians’ engagement in SDM differently across different age groups.

Methods
Cross-sectional study using data from the 2014–2017 and 2019 Medical Expenditure Panel Surveys (MEPS).

Results
A weighted total of 7,795,608 psoriasis patients were identified. SDM Scores ranged from 1 to 4, with 4 representing the most favorable patient evaluation of their clinicians’ engagement in SDM. We conducted multivariate linear regression to compare mean SDM Scores in male psoriasis patients versus female psoriasis patients across different patient age groups. Female patients ages 60–69 perceived significantly greater clinician engagement in SDM compared to age-matched male patients (female patient perception of SDM 3.65 [95%CI:3.61–3.69] vs. male patient perception of SDM 3.50 [95%CI:3.43–3.58], p<0.005). The same trend of older female patients evaluating their clinicians’ engagement in SDM significantly higher than their age-matched male counterparts exists for the age group >70 (p<0.005). No significant differences between male and female patients’ evaluations of their clinicians’ engagement in SDM were demonstrated in subjects younger than 60. All calculations were adjusted for demographic and clinical factors.

Conclusions
Compared to older male psoriasis patients, older female psoriasis patients evaluated their clinicians to be more engaged in shared decision-making.
Protocol for the crowdsourced image-based morbidity hotspot surveillance for neglected tropical diseases (CIMS-NTDs)
Authors: Chukwuocha Uchechukwu Madukaku , Oyamienlen Christopher Sule , Bosede Ayoola Oluwaseun , Dozie Ikechukwu Nosike 
Published: May 2024

Introduction
Efficient NTDs elimination strategies require effective surveillance and targeted interventions. Traditional methods are costly and time-consuming, often failing to cover entire populations in case of movement restrictions. To address these challenges, a morbidity image-based surveillance system is being developed. This innovative approach which leverages the smartphone technology aims at simultaneous surveillance of multiple NTDs, enhancing cost-efficiency, reliability, and community involvement, particularly in areas with movement constraints. Moreover, it holds promise for post-elimination surveillance.

Methodology
The pilot of this method will be conducted across three states in southern Nigeria. It will target people affected by Neglected Tropical Diseases and members of their communities. The new surveillance method will be introduced to target communities in the selected states through community stakeholder’s advocacy meetings and awareness campaigns. The pilot which is set to span eighteen months, entails sensitizing NTDs-affected individuals and community members using signposts, posters, and handbills, to capture photos of NTDs manifestations upon notice using smartphones. These images, along with pertinent demographic information, will be transmitted to a dedicated server through WhatsApp or Telegram accounts. The received images will be reviewed and organized at backend and then forwarded to a panel of experts for identification and annotation to specific NTDs. Data generated, along with geocoordinate information, will be used to create NTDs morbidity hotspot maps using ArcGIS. Accompanying metadata will be used to generate geographic and demographic distributions of various NTDs identified. To protect privacy, people will be encouraged to send manifestation photos of the affected body part only without any identifiable features.

Evaluation protocol
NTDs prevalence data obtained using conventional surveillance methods from both the pilot and selected control states during the pilot period will be compared with data from the CIMS-NTDs method to determine its effectiveness.

Expected results and conclusion
It is expected that an effective, privacy-conscious, population inclusive new method for NTDs surveillance, with the potential to yield real-time data for the identification of morbidity hotspots and distribution patterns of NTDs will be established. The results will provide insights into the effectiveness of the new surveillance method in comparison to traditional approaches, potentially advancing NTDs elimination strategies.
Expression and localization of the mechanosensitive/osmosensitive ion channel TMEM63B in the mouse urinary tract
Authors: Dalghi Marianela G. , DuRie Ella , Ruiz Wily G. , Clayton Dennis R. , Montalbetti Nicolas , Mutchler Stephanie B. , Satlin Lisa M. , Kleyman Thomas R. , Carattino Marcelo D. , Shi Yun Stone , Apodaca Gerard 
Published: May 2024

AbstractThe epithelial cells that line the kidneys and lower urinary tract are exposed to mechanical forces including shear stress and wall tension; however, the mechanosensors that detect and respond to these stimuli remain obscure. Candidates include the OSCA/TMEM63 family of ion channels, which can function as mechanosensors and osmosensors. Using Tmem63bHA‐fl/HA‐fl reporter mice, we assessed the localization of HA‐tagged‐TMEM63B within the urinary tract by immunofluorescence coupled with confocal microscopy. In the kidneys, HA‐TMEM63B was expressed by proximal tubule epithelial cells, by the intercalated cells of the collecting duct, and by the epithelial cells lining the thick ascending limb of the medulla. In the urinary tract, HA‐TMEM63B was expressed by the urothelium lining the renal pelvis, ureters, bladder, and urethra. HA‐TMEM63B was also expressed in closely allied organs including the epithelial cells lining the seminal vesicles, vas deferens, and lateral prostate glands of male mice and the vaginal epithelium of female mice. Our studies reveal that TMEM63B is expressed by subsets of kidney and lower urinary tract epithelial cells, which we hypothesize are sites of TMEM63B mechanosensation or osmosensation, or both.
On maximal totally real embeddings
Authors: Pali Nefton 
Published: May 2024

AbstractWe consider complex structures with totally real zero section of the tangent bundle. We assume that the complex structure tensor is real-analytic along the fibers of the tangent bundle. This assumption is quite natural in view of a well-known result by Bruhat and Whitney. We provide explicit integrability equations for such complex structures in terms of the fiberwise Taylor expansion. In a particular geometric case considered in the literature, we explicit much further the fiberwise Taylor expansion of the complex structure as well as the integrability equations.
Second to fourth digit ratio (2D:4D) as the ‘anatomical marker’ and reproductive ‘hormonal fingerprint’ in the occurrence dental plaque accumulation
Authors: Dutta Sulagna , Nie Chin Win , Sarna Amrita , Hari Padmini , Sengupta Pallav 
Published: May 2024

Abstract

Objectives
Digit ratio (2D:4D), as endocrine fingerprint, can indicate prenatal androgen exposure. It serves as an anatomical marker for various systemic diseases and a few studies relating it to oral health. The present study aims to evaluate the association between digit ratio and susceptibility to dental plaque formation.

Methods
The study was conducted on young adults aged between 18 and 25 years. Digit ratio and reproductive hormones were measured; dental plaque score and gingival index (GI) were recorded. Data were analysed using the MedCalc. v.20.

Results
Male and female participants were categorized into two groups based on their digit ratios being either above or below the calculated average (0.99 for females, 0.98 for males). Those with a digit ratio below the average had a significantly higher mean dental plaque score (p < 0.0001) than those with ratios at or above the average. However, there was no significant difference in the GI between the two groups. Reproductive hormone profiles varied significantly between the higher and lower digit ratio groups for both sexes.

Conclusions
Digit ratio may find potential to be used as an anatomical marker to identify the susceptibility to dental plaque build-up.
Knowledge, attitudes, and practices regarding self-medication for acne among medical students in Beni-Suef University
Authors: Mohammed Lotfy Alshimaa Mohsen , Anwar Manal Mohamed , Nadi Aya Badawi , Ahmed Gehad S. 
Published: May 2024

Abstract

Objectives
To evaluate medical students’ knowledge, attitudes, and self-medication practices for acne vulgaris.

Methods
An analytical cross-sectional study was conducted at Beni-Suef University’s Faculty of Medicine from January 2023 to June 2023. A pre-structured questionnaire was used for the study.

Results
A total of 297 students (85.1 %) used self-medications for acne without a prescription. The total knowledge score of self-medication among the study participants was 3.81 ± 2.23. About 71.4 % knew about precautions, and 72.7 % of the participants reported that self-medication is part of self-care. There was a statistical significance between the total mean knowledge score and age (p=0.007), gender (p=0.013), and academic year (p=0.001).

Conclusions
A significant portion of students self-medicate about acne. The total knowledge score of self-medication was to some extent not relatively high. Educational programs can be developed to increase medical students’ awareness of the risks and benefits of self-medication, information on appropriate use of medications, and when to seek medical attention.
The salience of students’ body language during in-person and online lectures at a Canadian university
Authors: Salvato Giuliana 
Published: May 2024

Abstract
Professors teaching different disciplines at a university in Canada received an email invitation to fill-out an online questionnaire where they could reflect on and express their opinions about the pedagogical and communicative roles of the body during their lectures. The questionnaire was divided into two parts: one asking professors to comment on their own body language; the other inquiring about professors’ perception of their students’ body language usage. This article is specifically focused on the second part of the survey, where professors reacted to questions concerning awareness of students’ body language during classes held in-person and online. In investigating the perceived salient functions attributed to students’ body language, this study values multimodal competence, embodied communication, and it informs the concept of immediacy in the relationship between students and professors at the university level.
Elevated mRNA level indicates FSIP1 promotes EMT and gastric cancer progression by regulating fibroblasts in tumor microenvironment
Authors: Liu Yao , Jiang Xinju , Yan Xiuchun , Yang Shuo , Bian Xiulan , Wang Yue , You Qi , Zhang Lei 
Published: May 2024

Abstract
Fiber sheath interaction protein 1 (FSIP1) plays a crucial role in cancer development and occurrence, but its influence on gastric cancer is still unclear. In this study, differential mRNA analysis was performed by TCGA database for the Limma analysis algorithm, and the gene ontology, the Kyoto Encyclopedia of Genes and Genomes, and the gene set enrichment analysis (GSEA) were used for bioinformatics functional enrichment analysis. A gastric cancer cell model with FSIP1 mRNA knockdown was constructed by RNA interference. Cell counting kit-8 and transwell migration/invasion assay were performed to verify the cell function, and western blotting was employed to confirm the expression of target genes. The GSEA analysis revealed that FSIP1 was associated with epithelial-mesenchymal transition (EMT). The high expression group also had a significant positive correlation with the markers of fibroblast in tumor microenvironment (TME). Western blotting showed that FSIP1 was generally upregulated in gastric cancer cell lines. FSIP1 mRNA knockdown cell lines inhibited gastric cells proliferation, migration, and metastasis in vitro, and the protein levels of EMT-related markers N-cadherin and vimentin were reduced. Our work proved that FSIP1 promoted EMT by regulating fibroblasts in the TME, thereby promoting the carcinogenic activity of cancer cells in proliferation, invasion, and migration. FSIP1 may take a role of the occurrence and could be a potential therapeutic target and offer a new insight into the underlying mechanism of gastric cancer.
Correlation between serum 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D in response to analytical procedures; a systematic review and meta-analysis
Authors: Serdar Muhittin Abdulkadir , Arslan Fatma Demet , Saral Neslihan Yıldırım , Yücel Doğan 
Published: May 2024

Abstract

Objectives
In this study, the aim is to provide a more detailed understanding of vitamin D metabolism by evaluating the correlation between 1,25-dihydroxyvitamin D (1,25(OH)2D) and 25-hydroxyvitamin D (25(OH)D) according to the variations in measurement methods and clinical conditions.

Methods
We searched PubMed, Embase, and Web of Science for studies reporting correlation results between 1,25(OH)2D and 25(OH)D. We performed a meta-analysis based on the correlation results of 1,25(OH)2D and 25(OH)D in different clinical conditions. We included a total of 63 studies and our laboratory’s results in the meta-analysis. The studies were categorized into high-quality methods group (HQMG), medium-quality methods group (MQMG), and low-quality methods group (LQMG) based on the 25(OH)D and 1,25(OH)2D measurement.

Results
In the healthy, renal disease, and other disease groups, the highest correlation values were observed in the studies categorized as HQMG, with values of 0.35 (95 % CI; 0.23–0.48), 0.36 (95 % CI; 0.26–0.42), and 0.36 (95 % CI; 0.22–0.48), respectively. Significant statistical heterogeneity was observed in the healthy, renal disease, and other disease groups, with I2 values of 92.4 , 82.7, and 90.7 %, respectively (p<0.001). Both Funnel plots and the results of Egger’s and Begg’s tests indicated no statistically significant bias across all studies.

Conclusions
A significantly low correlation was found between 25(OH)D and 1,25(OH)2D. However, higher correlations were found in the studies categorized as HQMG. Various factors, including methodological inadequacies and disparities, might contribute to this. In the future, with more accurate and reproducible measurements of 1,25(OH)2D, a clearer understanding of vitamin D metabolism will be achieved.
Gletschertourismus ohne Eis? Die Transformation und Positionierung von alpinen Gletschertourismus-Standorten in Zeiten des Klimawandels
Authors: Mayer Marius , Sacher Philipp , Böhme Marc , Eckert Marina , Salim Emmanuel 
Published: May 2024

Zusammenfassung
Der Klimawandel führt zu einem noch nie dagewesenen Gletscherschwund in den Alpen. Daher analysiert dieser Beitrag, wie BesucherInnen von Gletschertourismusstandorten diesen Landschaftswandel wahrnehmen und wie sich diese Standorte positionieren könnten, wenn ihre Hauptattraktionen verschwinden. Konzeptionell verknüpfen wir den wissenschaftlichen Diskurs über den Last Chance Tourism (LCT) mit Positionierung und den touristischen Attraktionssystemen von Leiper. Wir befragten die BesucherInnen von sechs alpinen Gletschertourismusstandorten (n=1330) zu ihrer Besuchsmotivation und ihrer Klimawandelwahrnehmung und verwendeten eine latente Klassenanalyse zur BesucherInnensegmentierung. Eine zweite Befragung an der Pasterze/Franz-Josefs-Höhe (n=201) gibt Einblicke in die Positionierung von Gletschertourismusstandorten und die Rolle des Gletschers als Kern des touristischen Attraktionssystems. Die Ergebnisse zeigen, dass LCT-Motivationen für BesucherInnen aller Standorte wichtig sind, die Gletscher als gefährdete Objekte wahrnehmen. Das Beispiel der Pasterze zeigt, dass für die meisten BesucherInnen der Gletscher als solcher nicht primär ausschlaggebend für die Reiseentscheidung ist, sondern eher einen (kleiner werdenden) Teil des gesamten Landschaftserlebnisses darstellt. Eine LCT-Positionierung wäre daher als Strategie zu eng und zu kurzsichtig, während eine Transformation von Gletscher- zu Landschaftswandel-Destinationen eine tragfähige Positionierung mit langfristiger Perspektive zu sein scheint.
Triangular cross-section beam splitters in silicon carbide for quantum information processing
Authors: Majety Sridhar , Saha Pranta , Kekula Zbynka , Dhuey Scott , Radulaski Marina 
Published: May 2024

AbstractTriangular cross-section color center photonics in silicon carbide is a leading candidate for scalable implementation of quantum hardware. Within this geometry, we model low-loss beam splitters for applications in key quantum optical operations such as entanglement and single-photon interferometry. We consider triangular cross-section single-mode waveguides for the design of a directional coupler. We optimize parameters for a 50:50 beam splitter. Finally, we test the experimental feasibility of the designs by fabricating triangular waveguides in an ion beam etching process and identify suitable designs for short-term implementation.
Educação ambiental como instrumento da gestão pública no município de Parintins-Amazonas - Brasil
Authors: Azevedo Filho João D’Anúzio Menezes de , Pinto Selma Guimarães 
Published: May 2024

A Educação Ambiental é um instrumento importante na formação de uma consciência ambiental que interfere na gestão urbana e na melhoria da qualidade de vida local. O objetivo deste trabalho foi analisar o crescimento urbano da cidade de Parintins desde sua fundação aos dias de hoje e como a Educação Ambiental no contexto escolar pode intermediar a reintegração da sociedade com seu meio natural. A EA leva a mudanças de atitudes, valores, conhecimentos e a inserção de educadores e sociedade na transformação direta desse cenário de gradativa destruição e crescimento desordenado das cidades. Foram realizados levantamento bibliográfico, entrevista em oito escolas com 8 professores e 25 alunos onde o educador ambiental se destaca como mediador e coordenador na implantação de ações pedagógicas voltadas para EA e a responsabilidade individual. Conclui-se que, a Educação Ambiental é discutida e praticada, que a interdisciplinaridade é imprescindível para o êxito dessas práticas nos âmbitos formal e não formal.
Gastronomia e literatura ou a receita culinária como ficção e arte
Authors: Silva Antonio de Pádua Dias da 
Published: May 2024

Resumo: Apesar de aparentemente novo, o tema da culinária na literatura já foi trabalhado em livros e artigos que estreitam os laços entre esses dois campos de conhecimento, seja pela produção, mercado ou recepção. O objetivo deste artigo é lançar bases para pensar o gênero textual receita culinária como um subgênero literário ou arte, tomando como elo de sustentação entre esses dois discursos o conceito de ficção. Defende-se a ideia de que tanto a escrita criativa (literária) quanto a comumente escrita instrucional (receita culinária) unem-se pelo fator ficção, imaginação. Toma-se Papel manteiga para embrulhar segredos: cartas culinárias (2006), de Cristiane Lisbôa, como obra problematizadora desse gênero borrado, híbrido.
Palavras-Chave: receita; ficção; culinária; cartas; memória.
Ten-Year Survival Rate of 82% in 262 Cases of Arthroscopic Bone Marrow Stimulation for Osteochondral Lesions of the Talus
Authors: Rikken Quinten G.H. , Aalders Margot B. , Dahmen Jari , Sierevelt Inger N. , Stufkens Sjoerd A.S. , Kerkhoffs Gino M.M.J. 
Published: May 2024

Background:
The long-term sustainability of arthroscopic bone marrow stimulation (BMS) for osteochondral lesions of the talus (OLT) remains a matter of debate. The primary aim of the present study was to assess the 10-year survival free from revision in ankles that had undergone arthroscopic BMS for an OLT. The secondary aim was to evaluate the influence of baseline patient and lesion characteristics on survival.

Methods:
Patients who underwent arthroscopic BMS for a symptomatic OLT and had a minimum follow-up of 10 years were included to assess procedure survival. The primary outcome, the 10-year cumulative survival rate, was analyzed by the Kaplan-Meier survival method. Secondary outcomes were the median time to revision and the effects of baseline factors (lesion size, primary or non-primary lesion type, preoperative cysts, and obesity as defined by a body mass index [BMI] of ≥30 kg/m2) on survival, analyzed with a Cox regression model and reported using hazard ratios (HRs).

Results:
The 262 included patients had a mean follow-up of 15.3 ± 4.8 years. The 10-year cumulative survival rate of the arthroscopic BMS procedures was 82% (95% confidence interval [CI]: 77% to 87%). At 15 years of follow-up, the cumulative survival rate was 82% (95% CI: 76% to 86%). The median time to revision was 2.4 years (interquartile range: 1.3 to 5.1 years). Of the baseline factors, obesity (HR: 3.0 [95% CI: 1.44 to 6.43], p < 0.01) was associated with decreased survival. Lesion size (HR: 0.9 [95% CI: 0.5 to 1.8], p = 0.8), non-primary lesion type (HR: 1.8 [95% CI: 0.9 to 3.4], p = 0.1), and the presence of preoperative cysts (HR: 1.0 [95% CI: 0.6 to 1.9], p = 0.9) were not significantly associated with survival.

Conclusions:
At a minimum follow-up of 10 years, the survival rate of arthroscopic BMS for OLT was 82%. At 15 and 20 years of follow-up, survival appeared to remain stable. Obesity (BMI ≥ 30 kg/m2) was associated with a higher likelihood of revision surgery. This risk factor should be incorporated into the treatment algorithm for OLT when counseling patients regarding surgery.

Level of Evidence:
Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Spontaneous Pneumorrhachis Secondary to Rhinovirus-Associated Emesis with Demonstrated Pathophysiology
Authors: Willenbring Taylor J , Stark Michael J , Tallarico Richard A 
Published: May 2024

Case:
This case of a 14-year-old boy presented with repetitive coughing secondary to a rhinovirus infection. In addition to pneumomediastinum, imaging demonstrated asymptomatic, yet significant holocord pneumorrhachis.

Conclusion:
Ectopic gas within the spinal canal, also referred to as pneumorrhachis or “epidural gas,” may be traumatic, iatrogenic, or less commonly, spontaneous. It is typically an incidental and asymptomatic finding in the setting of pneumomediastinum. Proposed pathophysiology includes air tracking through the intercostal fascial planes posteriorly through the neuroforamina, which offer a theoretical point of entry. Our case clearly demonstrates air along the entirety of the fascial planes confirming the proposed pathophysiology.