bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemostatic management of an infant with severe hemophilia A and tetralogy of Fallot for cardiac bypass surgery
Authors: Rodriguez Vilmarie , Burkhart Harold M. , Schmidt Kirstin A. , Pruthi Rajiv K. 
Published: October 2010

AbstractWe present the hemostatic management of severe hemophilia A of an infant with high risk of inhibitor development who underwent cardiac surgery for correction of tetralogy of Fallot. Continuous infusion of recombinant factor VIII resulted in good hemostasis during surgery and postoperatively. Unfortunately, the patient had inhibitor development 2 months after cardiothoracic surgery. Although cardiac surgery is successful, exposure to factor concentrates in severe hemophilia early in life might predispose a patient to inhibitor development. Pediatr Blood Cancer. 2010;55:1399–1401. © 2010 Wiley‐Liss, Inc.
Bilateral conjunctival extranodal marginal zone B‐cell lymphoma
Authors: Kram David E. , Brathwaite Carole D. , Khatib Ziad A. 
Published: October 2010

AbstractExtranodal marginal zone B‐cell lymphomas (EMZLs), while relatively common in adults, are rare entities in the pediatric population. A subclass of the typically aggressive non‐Hodgkin lymphomas, the few reported pediatric cases indicate that, as in adults, these tumors tend to be indolent. We present a case of EMZL arising in the conjunctivae in a 9‐year‐old male with bilateral disease. The patient was treated with surgical excision alone and has remained disease‐free 6 years after the operation. Pediatr Blood Cancer. 2010;55:1414–1416. © 2010 Wiley‐Liss, Inc.
Correlation between pre‐ or postoperative MRI findings and cerebellar sequelae in patients with medulloblastomas
Authors: Szathmari Alexandru , Thiesse Philippe , Galand‐desmé Sophie , Mottolese Carmine , Bret Philippe , Jouanneau Emmanuel , Guyotat Jacques , Lion‐François Laurence , Frappaz Didier 
Published: October 2010

AbstractIntroductionImmediate and delayed cerebellar dysfunction may be expected after surgical resection of a medulloblastoma. We investigated whether pre‐operative and delayed post‐operative MRI may correlate with such sequelae.Material and MethodsThe data of 31 patients in continuous complete remission after removal of medulloblastoma, irradiation and chemotherapy, were retrospectively reviewed. Magnetic Resonance Imaging (MRI) was analyzed for the following items: preoperative MRI (ratio of the surface of the tumor/posterior fossa, presence of ventricular dilatation or tonsilar hernia, involvement of the dentate nucleus) and delayed post‐operative MRI (amount of cerebellar parenchyma removed, degree of cerebellar atrophy, presence of T1 hypointense regions in remaining cerebellar area and removal of region containing dentate nucleus). These data were correlated with immediate and long‐term cerebellar syndrome and daily life repercussions.ResultsOn preoperative MRI, the ratio of the surface of the tumor/posterior fossa and the presence of tonsilar hernia were significantly correlated with long‐term sequelae on speech (respectively P = 0.027 and P = 0.05). Initial supratentorial ventricular dilatation was correlated with ability to sustain adequately daily tasks (P = 0.002). On delayed MRI, cerebellar atrophy was inversely correlated with ability to sustain daily tasks (P = 0.002). Hypointense T1 territory in remaining cerebellar parenchyma significantly correlated with immediate post‐operative cerebellar syndrome (P = 0.01) and showed a tendency for post‐operative mutism (P = 0.087) but was not correlated with any long‐term sequelae.ConclusionIncreased cranial pressure on initial MRI and cerebellar atrophy detected on subsequent MRI studies correlated with immediate and long‐term cerebellar sequelae. Pediatr Blood Cancer. 2010;55:1310–1316. © 2010 Wiley‐Liss, Inc.
Aeration properties of a new sleeping surface for infants
Authors: Bar‐Yishay Ephraim , Gaides Mark , Goren Avner , Szeinberg Amir 
Published: October 2010

AbstractBackgroundProne sleeping position, use of soft mattresses and head covering by bedclothes are known risk factors for sudden infant death syndrome (SIDS). Rebreathing carbon dioxide (CO2) may be a possible mechanism or a confounding factor of SIDS.ObjectiveTo compare the aeration properties of a new concept of infant sleeping surface (Net) to three commercial mattresses advertised to improve aeration and to two standard infant mattresses.DesignTwo experiments were performed: (I) A container (head box), filled with 7% CO2 mixture, was opened to the mattress to allow gas mixture to passively diffuse outside and equilibrate with the surrounding room air. (II) Simulation of normal breathing of an infant, using a unidirectional reciprocal syringe, to determine CO2 accumulation within the head box.MethodsCO2 concentrations in the head box were continuously measured until CO2 levels fell below 1% or for 5 min (experiment I), or until CO2 accumulation levels plateaued or for 6 min (experiment II).ResultsThe Net had a significantly faster rate of CO2 elimination (88.5 ± 4.6 and 91.9 ± 0.9 sec, Net alone and when covered with a sheet, respectively) compared to 238.3 ± 14.2 sec to 387.8 ± 7.9 sec for the other mattresses (P < 0.001). Only the Net was able to prevent CO2 accumulation with maximal CO2 levels (0.56 ± 0.03% and 1.16 ± 0.05%; Net alone and when covered with a sheet, respectively) significantly lower than the range of 4.6–6.3% for the other mattresses (P < 0.001).ConclusionsThe new sleeping surface exhibited significantly better aeration properties in dispersing CO2 and in preventing its accumulation. Pediatr. Pulmonol. 2011; 46:193–198. © 2011 Wiley‐Liss, Inc.
Burning Characteristics and Thermochemical Behavior of AP/HTPB Composite Propellant Using Coarse and Fine AP Particles
Authors: Kohga Makoto 
Published: October 2010

AbstractThe burning rate of AP/HTPB composite propellant increases with increasing AP content and with decreasing AP size. In addition, the burning rate can be enhanced with the addition of Fe2O3. The burning characteristics and thermal decomposition behavior of AP/HTPB composite propellant using coarse and fine AP particles with and without Fe2O3at various AP contents were investigated to obtain an exhaustive set of data. As the AP content decreased, the burning rate decreased and the propellants containing less than a certain AP content self‐quenched or did not ignite. The self‐quenched combustion began at both lower and higher pressures. The lower limit of AP content to burn the propellant with coarse AP was lower than that with fine AP. The lower limit of AP content to burn was decreased by the addition of Fe2O3. The thermal decomposition behavior of propellants prepared with 20–80 % AP was investigated. The decrease in the peak temperature of the exothermic decomposition suggested an increased burning rate. However, a quantitative relationship between the thermochemical behavior and the burning characteristics, such as the burning rate and the lower limit of AP content to burn, could not be determined.
HDL and sphingosine‐1‐phosphate activate stat3 in prostate cancer DU145 cells via ERK1/2 and S1P receptors, and promote cell migration and invasion
Authors: Sekine Yoshitaka , Suzuki Kazuhiro , Remaley Alan T. 
Published: October 2010

AbstractBACKGROUNDAndrogen deprivation therapy in men with prostate cancer leads to a significant increase of high density lipoprotein (HDL), but the effect of HDL on prostate cancer is unknown. Recently, HDL, which transports sphingosine‐1‐phosphate (S1P), was reported to activate signal transducer and activator of transcription 3 (Stat3) in cardiomyocytes. In this study, we examined the effect of HDL and S1P on Stat3 activation in prostate cancer cells and the involvement of S1P receptors in this process in three prostate cancer cell lines (PC‐3, LNCaP, and DU145).METHODSDiscordial reconstituted(r) HDL containing POPC, apoA‐1, and S1P were prepared by the cholate dialysis method. The phosphorylations of Stat3, ERK1/2, and Akt were detected by Western blotting. Cell migration and invasion were determined by wound‐healing assay and matrigel invasion chamber assay.RESULTSHDL increased serine 727 phosphorylation of Stat3, but not tyrosine 705 only in DU145 cells. S1P and rHDL‐S1P also induced the phosphorylation, but not rHDL without S1P. They also induced DU145 cells migration and invasion. PD98059, a MEK inhibitor, and pertussis toxin, a Gi inhibitor, attenuated HDL‐, S1P‐, and rHDL‐S1P‐induced Stat3 phosphorylation, whereas LY294002, a PI3K inhibitor, had no effect. Concerning S1P receptors, S1P1 expression was much lower than S1P2 and S1P3 in DU145 cells. Both JTE013, a S1P2 antagonist, and VPC23019, a S1P1/S1P3 antagonist, attenuated HDL‐, S1P‐, and rHDL‐S1P‐induced Stat3 phosphorylations and cell migrations.CONCLUSIONSThese results suggest that the change in HDL plasma levels by androgen deprivation therapy may alter prostate cancer growth and metastasis. Prostate 71:690–699, 2011. © 2010 Wiley‐Liss, Inc.
X‐ray composition analysis of nonpolar GaInN/GaN multiple quantum well structures
Authors: Bremers H. , Schwiegel A. , Hoffmann L. , Jönen H. , Rossow U. , Thalmair J. , Zweck J. , Hangleiter A. 
Published: October 2010

AbstractDetermination of compositions in multiple quantum well structures is a critical issue. Until now only few experimental description of determination of concentrations in the nonpolar m‐ or a‐direction in III‐nitrides by means of X‐ray diffraction has been published. Using the example of GaInN/GaN multiple quantum well structures we present different methods to determine the indium concentration. After presenting the relevant elasticity relations we adopt a step model introduced by Segmüller and Blakeslee to nonpolar directions. This model allows a simulation of symmetrical $2{\theta} {-} {\omega} $ scans. We will discuss the possibilities and also the limitations of this model. Additionally, we present a method to determine concentrations by using the peak position of the zero order superlattice peak. Finally, we compare the methods using samples grown on m‐plane SiC and bulk m‐plane GaN.
Three‐dimensional GaN for semipolar light emitters
Authors: Wunderer T. , Feneberg M. , Lipski F. , Wang J. , Leute R. A. R. , Schwaiger S. , Thonke K. , Chuvilin A. , Kaiser U. , Metzner S. , Bertram F. , Christen J. , Beirne G. J. , Jetter M. , Michler P. , Schade L. , Vierheilig C. , Schwarz U. T. , Dräger A. D. , Hangleiter A. , Scholz F. 
Published: October 2010

AbstractSelective‐area epitaxy is used to form three‐dimensional (3D) GaN structures providing semipolar crystal facets. On full 2‐in. sapphire wafers we demonstrate the realization of excellent semipolar material quality by introducing inverse GaN pyramids. When depositing InGaN quantum wells on such a surface, the specific geometry influences thickness and composition of the films and can be nicely modeled by gas phase diffusion processes. Various investigation methods are used to confirm the drastically reduced piezoelectric polarization on the semipolar planes. Complete electrically driven light‐emitting diode test structures emitting in the blue and blue/green spectral regions show reasonable output powers in the milliwatt regime. Finally, first results of the integration of the 3D structures into a conventional laser design are presented.
Exploration of the (ethanol)4–water heteropentamers potential energy surface by simulated annealing and Ab initio molecular dynamics
Authors: Mejía Sol M. , Orrego Juan F. , Espinal Juan F. , Fuentealba Patricio , Mondragón Fanor 
Published: October 2010

AbstractA DFT electronic structure study of the (ethanol)4–water heteropentamers at the B3LYP/6‐31+G(d) model chemistry was carried out. To get determine possible configurations, the potential energy surface (PES) was explored with two methods: simulated annealing and ab initio molecular dynamics. The results suggest that the PES is very flat. A total of 81 stable structures were determined. These structures were classified into 16 different geometric patterns according to geometric criteria like the number of hydrogen bonds and their spatial arrangement: cyclic, bicyclic, or lineal patterns. Thermodynamic stability was used for defining the order of such classification. Hydrogen bonds are mutually disturbed due to the existence of cooperative effects. Cooperativity affects the nature of the hydrogen bonds and the overall stability of the ethanol–water system given that the strongest interactions are markedly covalent and the most stable geometric pattern corresponds to the pentagonal arrangement. These observations were supported by the analysis of the loss of atomic charge of the hydrogen atoms involved in hydrogen bonds. These hydrogen bonds were classified as primary and secondary hydrogen bonds: OH···O and CH···O, respectively. For comparative purposes, some (ethanol)5, (methanol)5, and (methanol)4–water clusters were characterized in this study. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
The chemical bond overlap plasmon as a tool for quantifying covalency in solid state materials and its applications to spectroscopy
Authors: Moura Renaldo T. , Malta Oscar L. , Longo Ricardo L. 
Published: October 2010

AbstractThe polarizability of the charge density in the overlap region of a chemical bond has already been correlated to its covalency in diatomic molecules and in lanthanide compounds. This concept has been successfully extended in the present contribution to alkali halide MX (M = Li, Na, K and X = F, Cl, Br) crystals. For more covalent compounds such as silicon, aluminum, and tin oxides the proposed treatment of the crystalline environment cannot be considered quantitative. However, for MX systems, good correlations between the chemical bond overlap polarizabilities and macroscopic properties such as molar polarizabilities and energy band gaps were established. In addition, the overlap region is regarded as a localized plasmon‐like charge distribution (chemical bond overlap plasmon–CBOP), thus leading to absorption and Raman scattering processes by the overlap region, and electron energy‐loss spectroscopy. The processes associated with CBOP excitations and energy‐loss have been used to assign structures and shoulders present in spectra of MX crystals that have either not been assigned or ambiguously assigned as excitons or surface plasmons excitations. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2010
Theoretical study of mechanism of cycloaddition reaction between dimethyl‐silylene carbene [(CH3)2SiC:] and formaldehyde
Authors: Lu Xiu Hui , Xiang Ping Ping , Lian Zhen Xia , Li Yong Qing 
Published: October 2010

AbstractThe mechanism of the cycloaddition reaction between singlet dimethyl‐silylene carbene and formaldehyde has been investigated with MP2/6‐31G* method, including geometry optimization and vibrational analysis for the involved stationary points on the potential energy surface. The energies of the different conformations are calculated by zero‐point energy and CCSD (T)//MP2/6‐31G* method. From the potential energy profile, it can be predicted that the reaction has two competitive dominant reaction pathways. The main products of first dominant reaction pathway are a planar four‐membered ring product (P4) and its H‐transfer product (P4.2). The main product of second dominant reaction pathway is a silicic bis‐heterocyclic compound (P5). © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Comparative semiempirical and DFT study of styrylnaphthalenes and styrylquinolines and their photocyclization products
Authors: Budyka Mikhayl F. , Oshkin Ilia V. 
Published: October 2010

AbstractSemiempirical molecular orbital (PM3, PM6, and RM1) and density functional theory (DFT) (B3LYP/6‐31G*) studies are carried out for 1‐ and 2‐styrylnaphthalenes and their aza‐derivatives—2‐ and 4‐styrylquinolines. Relative stabilities of three isomeric forms: E‐ and Z‐isomers and the closed‐ring dihydrocyclophotoproduct (derivative of dihydrophenanthrene) are calculated. Compared to PM3, PM6 and especially RM1 understate heats of formation; in some cases, PM6 and RM1 even place Z‐isomer in energy below E‐isomer. PM3 rather close to DFT predicts heats of isomerization reaction, whereas PM6 and especially RM1 underestimate these values. Semiempirical methods in comparison with DFT markedly underestimate heats of cyclization reaction; however, reproduce trends in relative stabilities of different isomers in dependence on the structure of styrylnaphthalenes and styrylquinolines. Qualitative correlation is found between calculated relative stabilities of the closed‐ring forms (heats of cyclization reaction) and experimental data: cyclized products with low heats of cyclization are observed in steady‐state photolysis and those with high heats of cyclization are not. In the latter case, the closed‐ring compounds, if formed in the excited state, due to thermal instability decompose rapidly with ring opening in the ground state that prevents their observation. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Ab initio and AIM studies on typical π‐type and pseudo‐π‐type halogen bonds: Comparison with hydrogen bonds
Authors: Zeng Yanli , Zhang Xueying , Li Xiaoyan , Zheng Shijun , Meng Lingpeng 
Published: October 2010

AbstractSeries of typical π‐type and pseudo‐π‐type halogen‐bonded complexes B···ClY and B···BrY and hydrogen‐bonded complex B···HY (B = C2H4, C2H2, and C3H6; Y = F, Cl, and Br) have been investigated using the MP2/aug‐cc‐pVDZ method. A striking parallelism was found in the geometries, vibrational frequencies, binding energies, and topological properties between B···XY and B···HY (X = Cl and Br). It has been found that the lengths of the weak bondd(X···π)/d(H···π), the frequencies of the weak bond ν(X···π)/ν(H···π), the frequency shifts Δν(XY)/Δν(HY), the electron densities at the bond critical point of the weak bonds ρc(X···π)/ρc(H···π), and the electron density changes Δρc(XY)/Δρc(HY) could be used as measures of the strengths of typical π‐type and pseudo‐π‐type halogen/hydrogen bonds. The typical π‐type and pseudo‐π‐type halogen bond and hydrogen bond are noncovalent interactions. For the same Y, the halogen bond strengths are in the order B···ClY < B···BrY. For the same X, the halogen bond strength decreases according to the sequence F > Cl > Br that is in agreement with the hydrogen bond strengths B···HF > B···HCl > B···HBr. All of these typical π‐type and pseudo‐π‐type hydrogen‐bonded and halogen‐bonded complexes have the “conflict‐type” structure. Contour maps of the Laplacian of π electron density indicate that the formation of B···XY halogen‐bonded complex and B···HY hydrogen‐bonded complex is very similar. Charge transfer is observed from B to XY/HY and both the dipolar polarization and the volume of the halogen atom or hydrogen atom decrease on B···XY/B···HY complex formation. © 2010 Wiley Periodicals, Inc. Int J Quantum Chem, 2011
Sequential diagnostic trial designs
Authors: Dong Ting , Tang Liansheng 
Published: October 2010

AbstractGroup sequential design (GSD) as an alternative of the fixed sample design addresses both cost and ethical concerns in diagnostic trials. In this article, we review GSD methods for comparing the diagnostic accuracy of markers in diagnostic trials. We also review sample size calculation methods in such trials.WIREs Comp Stat2011 3 79–83 DOI: 10.1002/wics.136This article is categorized under:Applications of Computational Statistics > Clinical Trials
Culture in Asian American Community Psychology: Beyond the East–West Binary
Authors: Okazaki Sumie , Saw Anne 
Published: October 2010

AbstractIn response to a call to better integrate culture in community psychology (O'Donnell in American Journal of Community Psychology 37:1–7 2006), we offer a cultural‐community framework to facilitate a collaborative engagement between community psychologists and ethnic minority communities, focusing on Asian American communities as illustrations. Extending Hays' (Addressing cultural complexities in practice: Assessment, diagnosis, and therapy, American Psychological Association, Washington, DC, 2008) ADDRESSING framework for considering cultural influences on a counseling relationship, the proposed framework provides a broad but systematic guidepost for considering three major cultural‐ecological influences on Asian American communities: Race and Ethnicity (R), Culture (C), and Immigration and Transnational Ties (I). We provide a sequence of steps that incorporate the ADDRESSING and the RCI frameworks to facilitate the collaborative community‐based research or social action.
Reconcilable Differences? Human Diversity, Cultural Relativity, and Sense of Community
Authors: Townley Greg , Kloos Bret , Green Eric P. , Franco Margarita M. 
Published: October 2010

AbstractSense of community (SOC) is one of the most widely used and studied constructs in community psychology. As proposed by Sarason in (The Psychological sense of community: prospects for a community psychology, Jossey‐Bass, San Francisco, 1974), SOC represents the strength of bonding among community members. It is a valuable component of community life, and it has been linked to positive mental health outcomes, citizen participation, and community connectedness. However, promotion of SOC can become problematic in community psychology praxis when it conflicts with other core values proposed to define the field, namely values of human diversity, cultural relativity, and heterogeneity of experience and perspective. Several commentators have noted that promotion of SOC can conflict with multicultural diversity because it tends to emphasize group member similarity and appears to be higher in homogeneous communities. In this paper, we introduce the idea of a community‐diversity dialectic as part of praxis and research in community psychology. We argue that systematic consideration of cultural psychology perspectives can guide efforts to address a community‐diversity dialectic and revise SOC formulations that ultimately will invigorate community research and action. We provide a working agenda for addressing this dialectic, proposing that systematic consideration of the creative tension between SOC and diversity can be beneficial to community psychology.
Effects of enzyme replacement therapy on growth in patients with mucopolysaccharidosis type II
Authors: Schulze‐Frenking G. , Jones Simon A. , Roberts J. , Beck M. , Wraith J. E. 
Published: October 2010

AbstractMucopolysaccharidosis type II (MPS II; Hunter syndrome) is an X‐linked, recessive, lysosomal storage disorder caused by deficiency of iduronate‐2‐sulfatase. It has multisystemic involvement, with manifestations in the brain, upper respiratory tract, heart, abdomen, joints and bones. Bone involvement leads to decreased growth velocity and short stature in nearly all patients. A therapeutic option for patients with MPS II is enzyme replacement therapy (ERT) with idursulfase (Elaprase®). We compared annual growth rates before and during ERT in 18 patients from Mainz, Germany, and Manchester, UK. Group 1 included nine patients who started ERT before 10 years of age; group 2 contained nine patients aged more than 10 years at the start of ERT. All patients had received weekly or biweekly ERT or placebo for 1 year, followed by ERT for more than 3 years. For patients in group 1, the mean (± SD) height increase was 14.6 ± 5.5 cm during 3 years of ERT. Only one patient in this group (who was below the 3rd percentile when starting ERT) deviated from the normal growth curve over this time. Patients in group 2 had a mean height increase of 8.1 ± 1.7 cm after 3 years of ERT compared with an increase of 1 cm in the year before ERT. ERT seems to have a positive influence on growth in patients with MPS II. Most benefit is seen in patients beginning ERT before the age of 10 years. This supports the recommendation that ERT should be started as early as possible in patients with MPS II.