bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rumination, gender, and depressive symptoms associated with caregiving strain in bipolar disorder
Authors: Perlick D. A. , Gonzalez J. , Michael L. , Huth M. , Culver J. , Kaczynski R. , Calabrese J. , Miklowitz D. J. 
Published: May 2012

Perlick DA, Gonzalez J, Michael L, Huth M, Culver J, Kaczynski R. Calabrese J. Miklowitz DJ. Rumination, gender, and depressive symptoms associated with caregiving strain in bipolar disorder.Objective:  To evaluate the associations between indices of caregiving strain, ruminative style, depressive symptoms, and gender among family members of patients with bipolar disorder.Method:  One hundred and fifty primary caregivers of patients enrolled in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP‐BD) participated in a cross‐sectional study to evaluate the role of ruminative style in maintaining depressive symptoms associated with caregiving strain. Patient lifetime diagnosis and current episode status were evaluated by the Affective Disorder Evaluation and the Clinical Monitoring Form. Caregivers were evaluated within 30 days of the patient on measures of family strain, depressive symptoms, and ruminative style.Results:  Men and women did not differ on depression, caregiver strain, or ruminative style scores. Scores suggest an overall mild level of depression and moderate caregiver strain for the sample. Greater caregiver strain was significantly associated (P < 0.05) with rumination and level of depressive symptoms, controlling for patient clinical status and demographic variables. Rumination reduced the apparent association between strain and depression by nearly half. Gender was not significantly associated with depression or rumination.Conclusion:  Rumination helps explain depressive symptoms experienced by both male and female caregivers of patients with bipolar disorder. Interventions for caregivers targeted at decreasing rumination should be considered.
Illness perception and quality of life in patients with contact dermatitis
Authors: Benyamini Yael , Goner‐Shilo Daphna , Lazarov Aneta 
Published: May 2012

Background. People's subjective perceptions of illness are important determinants of their ways of coping with health threats and the ensuing physical and mental outcomes, including quality of life (QoL), which has been consistently reported to be impaired by contact dermatitis.Objectives. To investigate the relationships of subjective illness perceptions and dermatological QoL in atopic, contact and occupational dermatitis patients and a comparison group of patients with other dermatological diseases.Patients and methods. Three hundred and three patients of four diagnostic groups filled in the Brief Illness Perception Questionnaire and the Skindex‐16 (+ occupational impact items) Dermatological QoL questionnaire before clinical examination and patch testing.Results. Perceptions of serious consequences, greater symptom burden and more uncertainty and worry were associated with lower QoL (rs > 0.50). Overall, patients reported low personal control over their condition and low understanding of the disease (3.5 and 4.8, respectively, on a 0–10 scale). QoL was most impaired among occupational dermatitis patients (mean = 46) and least impaired among patients who were later diagnosed as suffering from conditions other than contact dermatitis (mean = 62).Conclusions. Identifying critical components of illness perceptions in patients with atopic, contact and occupational dermatitis may enable the design of consultations and interventions to fit patients' perceptions, which could affect their QoL.
Animal models of wound repair: Are they cutting it?
Authors: Ansell David M. , Holden Kirsty A. , Hardman Matthew J. 
Published: May 2012

AbstractCurrent understanding of the complex process of wound repair is based on decades of study. Integral to this understanding has been the use of in vitro and in vivo models to uncover the key molecular players. Now that major wound processes are more fully understood, therapeutic strategies can be developed to manipulate wound repair. Particularly important areas for future research include developing therapies to aid treatment of healing pathologies such as chronic wounds, and manipulating the normal healing processes to drive a more regenerative phenotype in adults. Here, we discuss the benefits and limitations of current animal‐based models and highlight the urgent need for improved predictive preclinical models for wound healing research. We conclude by suggesting directions where more robust models of chronic wound pathologies may arise, expediting the development of novel therapies.
Factors associated with missing teeth in the Brazilian elderly institutionalised population
Authors: Piuvezam Grasiela , de Lima Kenio Costa 
Published: May 2012

doi:10.1111/j.1741‐2358.2012.00655.x

Factors associated with missing teeth in the Brazilian elderly institutionalised population
Objective:  Identify factors associated with missing teeth in the elderly institutionalised population in Brazil.Methodology:  Cross‐sectional study of elderly institutionalised Brazilians with 1192 subjects. A questionnaire was applied as well as an epidemiological survey of oral health conditions in accordance with WHO. Factorial analysis was carried out with variables related to missing teeth, as well as the Fisher’s exact test, chi‐squared test and multiple logistic regression.Results:  Mean age was 76.3 (±9.8), 53.5% (638) of subjects were women and 717 (60.2) were dependent. Mean of Decayed Missing and Filled Teeth Index (DMFT index) was 29.4 (±4.9). The subjects that did not use upper and lower dentures were 61.5% (732) and 79.2% (944), respectively. Median number of missing teeth per person was 27.88 (±6.8) with a mean of 4 (±6.6) teeth present and 2.4 (±4.5) caries‐free teeth. Factors associated with missing teeth following multivariate analysis were: age, sex, self‐assessment of oral health, access to health services, type of institution and area of the country.Conclusions:  High level of tooth loss and low level of rehabilitation demonstrate precarious oral health. It is therefore necessary to improve institutional access mechanisms to public health facilities for the institutionalised elderly.
Identification of a potential tumor differentiation factor receptor candidate in prostate cancer cells
Authors: Sokolowska Izabela , Woods Alisa G. , Gawinowicz Mary Ann , Roy Urmi , Darie Costel C. 
Published: May 2012

Tumor differentiation factor (TDF) is a pituitary protein that is secreted into the bloodstream and has an endocrine function. TDF and TDF‐P1, a 20‐residue peptide selected from the ORF of TDF, induce differentiation in human breast and prostate cancer cells, but not in other cells. TDF has no known mechanism of action. In our recent study, we identified heat shock 70 kDa proteins (HSP70s) as TDF receptors (TDF‐Rs) in breast cancer cells. Therefore, we sought to investigate whether TDF‐R candidates from prostate cancer cells are the same as those identified in breast cancer cells. Here, we used TDF‐P1 to purify the potential TDF‐R candidates by affinity purification chromatography from DU145 and PC3 steroid‐resistant prostate cancer cells, LNCaP steroid‐responsive prostate cancer cells, and nonprostate NG108 neuroblastoma and BLK CL.4 fibroblast‐like cells. We identified the purified proteins by MS, and validated them by western blotting, immunofluorescence microscopy, immunoaffinity purification chromatography, and structural biology. We identified seven candidate proteins, of which three were from the HSP70 family. These three proteins were validated as potential TDF‐R candidates in LNCaP steroid‐responsive and in DU145 and PC3 steroid‐resistant prostate cancer cells, but not in NG108 neuroblastoma and BLK CL.4 fibroblast‐like cells. Our previous study and the current study suggest that GRP78, and perhaps HSP70s, are strong TDF‐R candidates, and further suggest that TDF interacts with its receptors exclusively in breast and prostate cells, inducing cell differentiation through a novel, steroid‐independent pathway.Structured digital abstract
TDF‐P1 physicallyinteracts with GRP78and HSP70 by pulldown (Viewinteraction)
GRP78 binds to TDF‐P1 by antibaitcoimmunoprecipitation (Viewinteraction)
TDF‐P1 physicallyinteracts with GRP78, HSP8, HSP70, HSP90‐beta, Sequestosome1 and valosin‐containing‐protein by pulldown (Viewinteraction)
Increased Risk of Sexual Dysfunction in Male Patients with Psoriasis: A Nationwide Population-Based Follow-Up Study
Authors: Chen Yi-Ju , Chen Chih-Chiang , Lin Ming-Wei , Chen Tzeng-Ji , Li Cheng-Yuan , Hwang Chian-Yaw , Chu Szu-Ying , Lee Ding-Dar , Chang Yun-Ting , Wang Wen-Jen , Liu Han-Nan 
Published: May 2012

ABSTRACT

Introduction
An association between psoriasis and sexual dysfunction (SD) has been explored. However, the risk of SD after the diagnosis of psoriasis relative to the age-matched general population remains unknown.

Aim
To clarify the risk of developing SD in male patients with psoriasis.

Methods
From 2000 to 2001, we identified 12,300 male patients with newly diagnosed psoriasis and 61,500 matching controls from National Health Insurance Database in Taiwan.

Main Outcome Measures
The two cohorts were followed up until 2008, and we observed the occurrence of SD by registry of SD diagnosis in the database. Stratified Cox proportional hazard regressions were used to calculate the 7-year SD risk for these two groups.

Results
Of the 73,800 sampled patients, 1,812 patients (2.46%) experienced SD during the 7-year follow-up period, including 373 (3.03% of patients with psoriasis) in the study group and 1,439 (2.34% of patients without psoriasis) in the comparison group. The hazard ratio (HR) for SD for patients with psoriasis was 1.27 times (95% confidence interval [CI], 1.11–1.46; P = 0.001) as high as that for patients without psoriasis after adjusting for age, monthly income, number of health-care visits, systemic treatment, and other comorbidities. Stratified analysis showed that the risk of SD was higher in patients older than 60 years old (HR: 1.42, 95% CI: 1.12–1.81) and patients with psoriatic arthritis (HR: 1.78, 95% CI: 1.08–2.91). However, the risk of SD was not significantly elevated in patients receiving systemic treatment, including retinoid, methotrexate, and cyclosporine.

Conclusions
Male patients with psoriasis are at increased risk of developing SD. Physicians should pay attention to the impact of psoriasis on psychosocial and sexual health, especially in old-aged patients.
Angiotensin II Increases Corpus Cavernosal Contractility and Oxidative Stress in Partial Bladder Outlet Obstructed Rabbits: Relevance to Erectile Dysfunction
Authors: Ertemi Hani , Lau David H.W. , Mikhailidis Dimitri P. , Mumtaz Faiz H. , Thompson Cecil S. 
Published: May 2012

ABSTRACT

Introduction
We investigated the effect angiotensin II (Ang II), a corpus cavernosal smooth muscle (CCSM) constrictor peptide, has on tissue taken from rabbits following chronic partial bladder outlet obstruction (PBOO), as this model is characterized by an increase in corpus cavernosal collagen deposition and a marked reduction and impaired relaxation of CCSM cells.

Aim
To determine the interaction between Ang II and nitric oxide (NO) and the development of oxidative stress (OS) in a rabbit model of chronic PBOO.

Methods
Corpus cavernosal tissue was obtained from 12 sham-operated and 20 PBOO rabbits. Organ bath studies determined Ang II/NO interaction on CCSM function using losartan (AT1 receptor antagonist), sodium nitroprusside (SNP, NO donor), electrical field stimulation (EFS), and vardenafil (phosphodiesterase type 5 inhibitor). The role of OS in the Ang II response was also determined using diphenylene iodonium chloride (DPI), the nicotinamide adenine dinucleotide phosphate oxidase inhibitor, which inhibits superoxide production and superoxide dismutase (SOD, the enzyme that accelerates the breakdown of superoxide).

Main Outcome Measure
Action of Ang II and AT1 receptor antagonist, as well as SOD and DPI on CCSM function.

Results
Ang II caused a dose-dependent contraction of CCSM strips that was enhanced in PBOO rabbits and inhibited by losartan, DPI, and SOD. CCSM relaxation induced by SNP/EFS was impaired in this model and improved by vardenafil and losartan.

Conclusions
These findings imply that the increased Ang II contractile response is a pathological consequence of PBOO and that AT1 receptor inhibition may be a therapeutic approach to treat ED associated with PBOO.
5-HT2A Receptor -1438 G/A Polymorphism and Serotonergic Antidepressant-Induced Sexual Dysfunction in Male Patients with Major Depressive Disorder: A Prospective Exploratory Study
Authors: Liang Chih-Sung , Ho Pei-Shen , Chiang Kuo-Tung , Su Hsuan-Chi 
Published: May 2012

ABSTRACT

Introduction
To date, few studies have specifically investigated the genetic determinants of antidepressant-induced sexual dysfunction (SD).

Aim
The aim of this prospective study was to examine whether the 5-HT2A receptor -1438 G/A polymorphism has functional consequences on sexual well-being in young adult men presenting with their first episode of major depressive disorder (MDD) after serotonergic antidepressant treatment.

Methods
Between May 2010 and June 2011, a total of 56 drug-naïve patients presenting with their first episode of MDD were recruited from a psychiatric hospital and received either a selective serotonin reuptake inhibitor or venlafaxine monotherapy; the patients were then genotyped. Over the course of antidepressant treatment, the population was divided into a SD group (N = 16) and a non-SD group (N = 29) based on the Arizona Sexual Experience Scale (ASEX). Participants who did not achieve a significant improvement, as assessed by the Hamilton Depression Rating Scale (HAMD-17), were excluded from the final data analysis.

Main Outcome Measures
The primary outcome measures were the differences in the genotype distribution and allele frequencies between groups.

Results
In the SD group, the AA genotype was significantly overrepresented (P = 0.004), and the mean baseline HAMD-17 score, the mean baseline ASEX score, and the mean end-point ASEX score were significantly higher than those in the non-SD group (P = 0.026, P = 0.004, and P &lt; 0.001, respectively). The mean end-point HAMD-17 score (P = 0.115) did not differ significantly between the two groups.

Conclusion
These results suggest that the AA genotype may be a genetic trait offering an opportunity to strengthen early detection of serotonergic antidepressant-induced SD in young adult male patients with MDD, whereas the G allele is protective against SD in this population.
PDEI-5 for Erectile Dysfunction: A Potential Role in Seizure Susceptibility
Authors: Matos Gabriela , Scorza Fulvio A. , Cavalheiro Esper A. , Tufik Sergio , Andersen Monica L. 
Published: May 2012

ABSTRACT

Introduction
There is a high prevalence of erectile dysfunction (ED) in men with epilepsy; however, few studies have been conducted concerning the treatment of ED in this neurological group.

Aim
The main purpose of this review is to highlight the influence of phosphodiesterase type 5 inhibitor (PDEI-5) for ED on seizure susceptibility.

Methods
All available online articles with information pertaining to PDEI-5 and seizure susceptibility were included in this review.

Main Outcome Measures
The main outcome assessed demonstrated the intriguing role of PDEI-5 and its metabolites on seizure susceptibility.

Results
Case reports in men without epilepsy described seizure occurrence and electrophysiological changes following sildenafil, tadalafil, or vardenafil treatment. Consistent with these findings, preclinical studies suggested a proconvulsant effect of PDEI-5 on models of seizure induction.

Conclusions
Evidence suggests an influence of PDEI-5 on seizure susceptibility in humans. In addition, preclinical studies have demonstrated the role of nitric oxide metabolites in the facilitation of paroxysmal phenomenon. Although there are many causes of seizures, medical professionals should be aware of the possible influence of PDEI-5 on seizure susceptibility. Further investigation by physicians and scientists is required to improve our understanding of this important topic.
Prefrontal EEG Correlation During Tower of Hanoi and WCST Performance: Effect of Emotional Visual Stimuli
Authors: Ruiz-Díaz Marina , Hernández-González Marisela , Guevara Miguel Angel , Amezcua Claudia , Ågmo Anders 
Published: May 2012

ABSTRACT

Introduction
Emotional stimuli elicit changes in the electroencephalographic (EEG) activity of several brain structures. Prefrontal cortex is involved in the processing of emotional stimuli and executive functions. The correlation analysis of EEG provides information about the functional coupling between areas. It is reasonable to expect that emotional activation will modify prefrontal coupling during the performance of executive tasks such as Tower of Hanoi or Wisconsin Card Sorting Test (WCST).

Aim
Determine whether the prefrontal EEG correlation during the performance of the Tower of Hanoi and WCST is affected by previous exposure to videos with sexual or aggressive content.

Main Outcome Measures
Prefrontal EEG coupling was determined by the Pearson correlation. Valence and general arousal were evaluated by the Self-Assessment Manikin Scale and sexual arousal with a Sexual Arousal Scale. Computerized versions of the Towers of Hanoi and WCST provided data on prefrontal executive functions.

Methods
EEG from the left and right prefrontal zones was recorded during the performance of the Tower of Hanoi and WCST immediately after the subjects were exposed to one of the videos (neutral, aggressive, and erotic).

Results
There was no difference between videos in the task performance parameters. Only the erotic video produced an increased prefrontal coupling in the slow bands (delta and theta) during the performance of the Tower of Hanoi, whereas a decreased coupling in the delta, theta, and alpha bands was observed during the WCST.

Conclusions
Prefrontal coupling was changed after exposure to the erotic video, and it is likely that enhanced sexual arousal was the main cause of this change. The correlation patterns obtained could be associated with particular cognitive strategies or to functional adaptations while being sexually aroused. The results of this study may contribute to an understanding of the central nervous mechanisms underlying the cognitive effects of sexual arousal.
Influence of inoculation with a Trichoderma bio‐inoculant on ectomycorrhizal colonisation of Pinus radiata seedlings
Authors: Minchin R.F. , Ridgway H.J. , Condron L. , Jones E.E. 
Published: May 2012

AbstractTrichoderma species, through mechanisms such as mycoparasitism, antibiosis, induced resistance and competition, are able to suppress the growth and activity of soil microbes and therefore have the potential to influence ectomycorrhizal (ECM) fungal colonisation. ECM colonisation potential of Pinus radiata seedlings inoculated with the commercially available Trichoderma species bio‐inoculant, ArborGuard™, was investigated in a commercial containerised nursery setting and in a separate glasshouse experiment. Application of ArborGuard™ to P. radiata seedlings in both the containerised nursery and glasshouse experiment had no detrimental effect on the ability of the naturally occurring ECM fungi to colonise the seedlings. Thelephora terrestris was the only ECM species colonising the P. radiata root tips in the containerised system while Tomentella ellisii was the dominant species found colonising the P. radiata root tips in the glasshouse experiment. No seedling growth promotion was observed with the addition of ArborGuard™. The results show that the Trichoderma bio‐inoculant ArborGuard™ does not affect ECM colonisation of P. radiata seedlings by Th. terrestris and T. ellisii in a containerised nursery system.
Comparing global warming potential, energy use and land use of organic, conventional and integrated winter wheat production
Authors: Tuomisto H.L. , Hodge I.D. , Riordan P. , Macdonald D.W. 
Published: May 2012

AbstractTo ensure a sustainable food supply for the growing population, the challenge is to find agricultural systems that can meet production requirements within environmental constraints and demands. This study compares the impacts of winter wheat production on energy use, land use and 100 years Global Warming Potential (GWP100) under different arable farming systems and farming practices. Life cycle assessment was used to simulate the impacts of organic, conventional and integrated farming (IF) systems along the production chain from input production up to the farm gate. The IF system models were designed to combine the best practices from organic and conventional systems to reduce negative environmental impacts without significant yield reductions. An integrated system that used food waste digestate as a fertiliser, and utilised pesticides and no‐tillage had the lowest energy use and GWP per functional unit of 1000 kg wheat output. When the impacts of some specific practices for reducing energy use and GWP were compared, the highest energy use reductions were achieved by replacing synthetic nitrogen fertilisers with anaerobically treated food waste or nitrogen fixing crops, increasing yields through crop breeding and using no‐tillage instead of ploughing. The highest GWP reductions were achieved by using nitrification inhibitors, replacing synthetic nitrogen fertilisers and increasing yields. The major contributors to the uncertainty range of energy use were associated with machinery fuel use and the assumed crop yields. For GWP results, the main source of uncertainty related to the N2O emissions. In conclusion, farming systems that combine the best practices from organic and conventional systems have potential to reduce negative environmental impacts while maintaining yield levels.
Differences in Morphometry and Activity among Tabanid Fly Assemblages in an Andean Tropical Montane Cloud Forest: Indication of Altitudinal Migration?
Authors: Cárdenas Rafael E. , Hernández‐L Nathalia , Barragán Álvaro R. , Dangles Olivier 
Published: May 2012

AbstractEvidence suggests that variations along ecological gradients shape organism traits such as behavior or morphometry. We studied the effect of altitude on the flight activity of tropical tabanid fly assemblages of one species of Stypommisa Enderlein along a 1 km altitudinal gradient on the northwestern slopes of the Ecuadorian Andes. Our objectives were as follows: (1) to test the hypothesis that highland individuals present larger flight body structures; and (2) to compare the flight activity patterns of flies’ assemblages among altitudes and correlate it with weather factors. We sampled specimens in Malaise traps at 1180, 1680 and 2180 m of altitude from 0600 to 1830 h for 20 d at each site. Seven weather variables were measured every hour and flight activity was inferred from relative tabanid fly abundances/hour in traps. We measured morphometrical parameters that included tabanid fly body size, thorax volume, wing area and wing loading. Flight activity patterns revealed a bimodal distribution at 1680 m, and two asynchronous unimodal distributions, one at 1180 and one at 2180 m. GLM analyses revealed that temperature, mist and rainfall were the best predictors of fly activity differences among altitudes. Morphometrical analyses showed that body size and thorax volume increased with increasing altitude. Synchronous groups of flies at different altitudes (those between 1180–1680(pm) m, and 1680(am)–2180 m) were morphologically similar, suggesting that flies could be capable of migrating from highlands to lowlands at defined hours of the day depending on forest weather conditions.