bluuebunny/crossref_metadata_2025_split huggingface dataset:
Robust Transient Semi‐Glue Tape: Ultrastrong Adhesion Empowered by Water Activation and Self‐Locking
Authors: Yao Le , Peng Xue , Zhu He , Zhang Qi , Zhu Shiping 
Published: June 2024

AbstractIn adhesive industry, tapes are renowned for their superior flexibility, repeatability, and ease of storage compared to glues. However, conventional adhesive tapes often suffer from low adhesion strength (<500 kPa). This work introduces an innovative adhesive tape composed of an amphiphilic copolymer and a hydrophobic ionic liquid, achieving an ultrahigh adhesion strength of up to 3.1 MPa on various substrates, making a record‐high strength to date for tape‐type adhesives. This exceptional adhesion performance is facilitated by water droplets applied at the bonding interface, transforming the adhesive surface into a glue‐like property without the need for curing treatments or additional auxiliary equipment. By combining the advantageous features of both glues and tapes, these adhesives are termed as transient semi‐glue tapes (TSGT). The mechanism behind such water activation and self‐locking process is elucidated, and a general preparation approach is developed. Furthermore, the repeatability and recyclability of TSGT are demonstrated, offering an ingenious solution to this long‐standing engineering challenge.
A Dual‐Targeting, Multi‐Faceted Biocompatible Nanodrug Optimizes the Microenvironment to Ameliorate Abdominal Aortic Aneurysm
Authors: Mo Fandi , Wang Chufan , Li Shiyi , Li Zheyun , Xiao Cheng , Zhang Yuchong , Hu Chengkai , Wang Enci , Lin Peng , Yuan Tong , Zuo Ziang , Fu Weiguo , Chen Xiaoyuan , Ren Lei , Wang Lixin 
Published: June 2024

AbstractAbdominal aortic aneurysm (AAA) is a highly lethal cardiovascular disease that currently lacks effective pharmacological treatment given the complex pathophysiology of the disease. Here, single‐cell RNA‐sequencing data from patients with AAA and a mouse model are analyzed, which reveals pivotal pathological changes, including the M1‐like polarization of macrophages and the loss of contractile function in smooth muscle cells (SMCs). Both cell types express the integrin αvβ3, allowing for their dual targeting with a single rationally designed molecule. To this end, a biocompatible nanodrug, which is termed EVMS@R‐HNC, that consists of the multifunctional drug everolimus (EVMS) encapsulated by the hepatitis B virus core protein modifies to contain the RGD sequence to specifically bind to integrin αvβ3 is designed. Both in vitro and in vivo results show that EVMS@R‐HNC can target macrophages as well as SMCs. Upon binding of the nanodrug, the EVMS is released intracellularly where it exhibits multiple functions, including inhibiting M1 macrophage polarization, thereby suppressing the self‐propagating inflammatory cascade and immune microenvironment imbalance, while preserving the normal contractile function of SMCs. Collectively, these results suggest that EVMS@R‐HNC presents a highly promising therapeutic approach for the management of AAA.
Atomic Level‐Macroscopic Structure‐Activity of Inhomogeneous Localized Aggregates Enabled Ultra‐Low Temperature Hybrid Aqueous Batteries
Authors: Yao Jia , Zhang Bao , Wang Xiaofang , Tao Li , Ji Jie , Wu Ziang , Liu Xingtai , Li Jingying , Gan Yi , Zheng Junjie , Lv Lin , Ji Xiao , Wang Hanbin , Zhang Jun , Wang Hao , Wan Houzhao 
Published: June 2024

AbstractThe utilization of hybrid aqueous electrolytes has significantly broadened the electrochemical and temperature ranges of aqueous batteries, such as aqueous zinc and lithium‐ion batteries, but the design principles for extreme operating conditions remain poorly understood. Here, we systematically unveil the ternary interaction involving salt‐water‐organic co‐solvents and its intricate impacts on both the atomic‐level and macroscopic structural features of the hybrid electrolytes. This highlights a distinct category of micelle‐like structure electrolytes featuring organic‐enriched phases and nanosized aqueous electrolyte aggregates, enabled by appropriate low donor number co‐solvents and amphiphilic anions. Remarkably, the electrolyte enables exceptional high solubility, accommodating up to 29.8 m zinc triflate within aqueous micelles. This configuration maintains an intra‐micellar salt‐in‐water setup, allowing for a broad electrochemical window (up to 3.86 V), low viscosity, and state‐of‐the‐art ultralow‐temperature zinc ion conductivity (1.58 mS cm−1 at −80 °C). Building upon the unique nature of the inhomogeneous localized aggregates, this micelle‐like electrolyte facilitates dendrite‐free Zn plating/stripping, even at −80 °C. The assembled Zn||PANI battery showcases an impressive capacity of 71.8 mAh g−1 and an extended lifespan of over 3000 cycles at −80 °C. This study opens up a promising approach in electrolyte design that transcends conventional local atomic solvation structures, broadening the water‐in‐salt electrolyte concept.
Updated absolute parameters and kinematics of IS CMa
Authors: Evcil Serkan , Adalalı Simge , Alan Neslihan , Canbay Remziye , Bilir Selcuk 
Published: June 2024

AbstractEclipsing binary systems are significant objects for astrophysics in that direct observations can determine the fundamental parameters of stars. In this study, we precisely determined the fundamental parameters of the binary component stars obtained by simultaneous analysis of radial velocities and the TESS light curve using the Wilson and Devinney code. Following the analysis, the masses and radii of the primary and secondary components were determined as , , and , , respectively. Furthermore, the distance of IS CMa is calculated as pc. On the basis of the analysis of the mid‐eclipse times, it was found that the variation in the orbital period is represented by an upward parabola. It has an increasing rate of = 1.09 10 day year. Using PARSEC stellar evolutionary tracks and isochrones with solar metallicity estimated the age of IS CMa as Gyr. Kinematic and Galactic orbital parameters of IS CMa were obtained from the astrometric and spectroscopic data of the system. The Galactic orbit analysis reveals that IS CMa formed inside the solar circle and it is a member of the young thin‐disc population.
Legitimation der kreislaufeffektiven Holzbauweise – Nachweis der Klimaschutzwirkung
Authors: Graf Jürgen , Hao Boran , Birk Stephan , Poteschkin Viktor , Shi Wenchang , Klopfer Reiner , Jagsch Christina , Ciesla Eva‐Maria 
Published: June 2024

AbstractDas Nachhaltigkeitsgebot fordert, dass nur maximal so viel Holz aus dem Wald entnommen wird, wie im gleichen Zeitraum nachwächst. Daher ist das jährlich zur Verfügung stehende Erntevolumen für die Verwendung im Bauwesen begrenzt, auch vor dem Hintergrund, dass andere Wirtschaftsbereiche verstärkt auf den Rohstoff zurückgreifen. Anzustreben ist dementsprechend die Maximierung der Kohlenstoffspeicherung als Summe aus dem im Wald gebundenen Kohlenstoff und der stofflichen Verwendung von Holz. Für das Bauwesen bedeutet dies die Langlebigkeit der Baukomponenten, indem die Ressource Holz kreislaufeffektiv eingesetzt wird. In diesem Aufsatz wird zum einen die strategische Herangehensweise zur Steigerung der Kreislauffähigkeit der Holzbauweise vorgestellt. Zum anderen wird der klimarelevante Nachweis der Notwendigkeit kreislaufeffektiven Bauens erbracht und mit einer dynamischen Bilanzierungsmethode nachgewiesen. Dazu wird für den Ressourcenverbrauch und das Treibhauspotenzial aufgezeigt, wie das kreislaufeffektive Bauen grundsätzlich und im Besonderen mit Holz quantifiziert werden kann.
Substitution Effects on Subcellular Organelle Localization in Live‐cell Imaging
Authors: Ghorpade Mohini , Soppina Virupakshi , Kanvah Sriram 
Published: June 2024

AbstractA series of D‐π‐A indole‐containing fluorescent probes were developed, followed by an investigation of their photophysical properties and compounds’ suitability for subcellular imaging in living cells. We demonstrate that the preference for mitochondrial localization was lost when morpholine was substituted, resulting in the accumulation of the molecule in the lysosomes. However, interestingly, the presence of a nitro group led to their localization within the lipid droplets despite the presence of the morpholine pendant. We also showcase the probes’ sensitivity to pH, the influence of added chloroquine, and the temperature response on the changes in fluorescence intensity within lysosomes. The design of the probes with strong intramolecular charge transfer and substantial Stokes shift could facilitate extensive application in various cellular lysosomal models and contribute to a better understanding of the mechanisms involved in stimuli‐responsive diseases.
ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte‐like 3T3‐L1 cells
Authors: Li Shuijie , Xu Rui , Yao Yao , Rousseau Denis 
Published: June 2024

AbstractATAD3 is a vital ATPase of the inner mitochondrial membrane of pluri‐cellular eukaryotes, with largely unknown functions but early required for organism development as necessary for mitochondrial biogenesis. ATAD3 knock‐down in C. elegans inhibits at first the development of adipocyte‐like intestinal tissue so we used mouse adipocyte model 3T3‐L1 cells to analyze ATAD3 functions during adipogenesis and lipogenesis in a mammalian model. ATAD3 function was studied by stable and transient modulation of ATAD3 expression in adipogenesis‐ induced 3T3‐L1 cells using Knock‐Down and overexpression strategies, exploring different steps of adipocyte differentiation and lipogenesis. We show that (i) an increase in ATAD3 is preceding differentiation‐induced mitochondrial biogenesis; (ii) downregulation of ATAD3 inhibits adipogenesis, lipogenesis, and impedes overexpression of many mitochondrial proteins; (iii) ATAD3 re‐expression rescues the phenotype of ATAD3 KD, and (iv) differentiation and lipogenesis are accelerated by ATAD3 overexpression, but inhibited by expression of a dominant‐negative mutant. We further show that the ATAD3 KD phenotype is not due to altered insulin signal but involves a limitation of mitochondrial biogenesis linked to Drp1. These results demonstrate that ATAD3 is limiting for in vitro mitochondrial biogenesis and adipogenesis/lipogenesis and therefore that ATAD3 mutation/over‐ or under‐expression could be involved in adipogenic and lipogenic pathologies.
Therapeutic potential of ethoxy mansonone G: A comprehensive exploration of its anticancer actions in breast cancer, colorectal cancer, and non‐small cell lung carcinoma
Authors: Fayyaz Amna , Basit Mahnoor , Farooq Andleeb , Khan Tooba , Ayub Umama , Khan Somia , Armaghan Muhammad , Mati‐ur‐Rahman  , Ammad Muhammad , Büsselberg Dietrich , Khan Khushbukhat , Habtemariam Solomon , Sharifi‐Rad Javad 
Published: June 2024

AbstractMansonone G (MG), a 1,2‐naphthoquinones with antiestrogenic, antimicrobial, and anti‐adipogenic activities, is derived from the heartwood of Mansonia gagei Drumm. Ethoxy mansonone G (EMG), an essential derivative of MG, has anticancer and antioxidant agent. EMG also has antiestrogen activity and is demonstrated to lower estrogen receptor expression in endocrine‐resistant cells. EMG significantly inhibits cell division, invasion, and anchorage‐dependent growth in all cancer types. Through the stimulation of the tumor protein (p53) and extracellular signal‐regulated kinase (ERK) signaling cascades, it also causes apoptosis. Moreover, it manifests its anti‐cancerous effects in toll‐like receptor pathways, c‐Jun N‐terminal kinase (c‐JNK), and nuclear factor kappa B (NF‐κB). EMG inhibits the phosphorylation of glycogen synthase kinase (GSK3), Erk, protein kinase B (Akt), and mammalian target of rapamycin (mTOR). By interfering with molecular cascades, EMG significantly reduces the metabolism of cancer cells. This paper focuses on the potential use of EMG in cancer treatment. Moreover, it states the methodology by which specific assays establish the anti‐cancerous role of EMG. Breast cancer, non‐small cell lung cancer, and colorectal cancer are only a few of the cancers for which EMG was shown to be effective. Through further research, EMG may be developed as a therapeutic solution to complications caused by cancer. This study presents EMG as a novel candidate for cancer therapy, offering a unique combination of pharmacological advantages and mechanistic insights that warrant further exploration and development toward addressing the complexities of cancer treatment.
Recent Progress in the Selective Hydrodeoxygenation of 5‐Hydroxymethylfurfural to 2,5‐Dimethylfuran With Metal‐Containing Catalysts
Authors: Gautam Rahul , Li Hu , Saravanamurugan Shunmugavel 
Published: June 2024

AbstractLiquid fuel, such as 2,5‐dimethylfuran (DMF), from biomass, is an efficient, potential alternative to fossil‐based fuels due to its exceptional properties, including lower volatility, a remarkable octane number, heightened energy density, and immiscibility with water. DMF can be the starting substrate for producing bio‐based p‐xylene through the Diels‐Alder reaction with ethylene to produce biobased polyethylene terephthalate (PET). This review, thus, discusses the catalytic role of various precious and non‐precious metals on different supports, such as carbon, metal‐oxide, zeolite, and hydrotalcite, for the production of DMF via catalytic hydrodeoxygenation (HDO) of 5‐hydroxymethylfurfural (HMF) based on the previously reported literature. Various characteristic properties of the employed catalytic materials, such as particle size, metal‐support and substrate interaction, surface area, porosity, and acidic and basic sites, are delineated, playing a crucial role in the HDO of HMF to DMF. The influence of various reaction parameters, such as hydrogen atmosphere, solvents‐ including hydrogen donor solvents‐ and temperature are also discussed.
Corrin Ring Modifications Reveal the Chemical and Spatial Requirements for the B12‐btuB Riboswitch Interaction
Authors: Musiari Anastasia , Reichenbach María , Gallo Sofia , Sigel Roland K. O. 
Published: June 2024

AbstractThe btuB riboswitch is a regulatory RNA sequence controlling gene expression of the outer membrane B12 transport protein BtuB by specifically binding coenzyme B12 (AdoCbl) as its natural ligand. The B12 sensing riboswitch class is known to accept various B12 derivatives, leading to a division into two riboswitch subclasses, dependent on the size of the apical ligand. Here we focus on the role of side chains b and e on affinity and proper recognition, i. e. correct structural switch of the btuB RNA, which belongs to the AdoCbl‐binding class I. Chemical modification of these side chains disturbs crucial hydrogen bonds and/or electrostatic interactions with the RNA, its effect on both affinity and switching being monitored by in‐line probing. Chemical modifications at sidechain b of vitamin B12 show larger effects indicating crucial B12‐RNA interactions. When introducing the same modification to AdoCbl the influence of any side‐chain modification tested is reduced. This renders the impact of the adenosyl‐ligand for B12‐btuB riboswitch recognition clearly beyond the known role in affinity.
Marked Response to Nivolumab by a Patient With SMARCA4‐Deficient Undifferentiated Urothelial Carcinoma Showing High PD‐L1 Expression: A Case Report
Authors: Arihara Yohei , Omori Ginji , Kobayashi Ko , Sugita Shintaro , Murase Kazuyuki , Kubo Tomohiro , Idogawa Masashi , Hasegawa Tadashi , Takada Kohichi 
Published: June 2024

ABSTRACTBackgroundSMARCA4 is a component gene of the SWI/SNF (SWItch/Sucrose NonFermentable) chromatin remodeling complex; undifferentiated tumors associated with its functional deletion have been described in several organs. However, no established treatment for these tumors currently exists.CaseIn this study, we report a case of a SMARCA4‐deficient undifferentiated urothelial carcinoma with high PD‐L1 expression that was effectively treated with nivolumab after early relapse following treatment for non‐invasive bladder cancer. The histological morphology of the rhabdoid‐like undifferentiated tumor of unknown primary led us to suspect a SWI/SNF‐deficient tumor, and subsequent immunostaining led to the diagnosis of a SMARCA4‐deficient undifferentiated tumor. This effort also led to the identification of the developmental origin of this SMARCA4‐deficient undifferentiated tumor as a non‐invasive bladder cancer. We also carried out a detailed immune phenotypic assay on peripheral T cells. In brief, a phenotypic change of CD8+T cells from naive to terminally differentiated effector memory cells was observed.ConclusionRegardless of the organ of cancer origin or cancer type, SWI/SNF‐deficient tumors should be suspected in undifferentiated and dedifferentiated tumors, and immune checkpoint inhibitors may be considered as a promising treatment option for this type of tumor. The pathogenesis of SMARCA4‐deficient anaplastic tumors awaits further elucidation for therapeutic development.
Controlled and restricted growth of cobalt nanoparticles embedded in ordered mesoporous carbons @ carbon nanotubes for metronidazole electrochemical biosensing study
Authors: Liu Fangxun , Zhao Yuxin , Zhang Tong , Shi Kun , Zheng Man , Zhao Pinyi , Yang Xin , Li Xin , Liu Shuang , Liu Jinpeng , Zhang Yufan , Li Pan , Wang Huan 
Published: June 2024

AbstractIn this article, controlled and restricted growth of cobalt nanoparticles embedded in ordered mesoporous carbon @ carbon nanotubes was designed and synthesized. SBA‐15 was used as template, the polydopamine (PDA) was used as bridging agent, the carbon and nitrogen source and cobalt phthalocyanine was used as cobalt source. In the process of high temperature calcination, ordered mesoporous carbons was carbonized, transition metal ions were reduced to transition metal nanoparticles, and carbon nanotubes were catalyzed growth by cobalt at the same time. Combined high surface area and stability of ordered mesoporous carbons, high electrocatalytic activity of transition metal nanoparticles and high proton transport performance of carbon nanotubes, our preparaed Co NPs @NOMC@CNTs showed excellent electrocatalytic performance for metronidazole. In this paper, cobalt nanoparticles were embedded into the ordered mesoporous carbons, which can greatly enhance the active site inside the electrocatalyst, and limit the growth of nanoparticles, and achieve efficient electrocatalytic performance. This provides new ideas and methods for the preparation of new materials embedded with metal nanoparticles. The preparation process of the composite material is simple, green and economical, the synthesis method is novel, the preparation material is efficient, the preparation cost is low, and it has a broad application prospect in the industrialization field of economical and green electrocatalyst.
Estimation of bed material transport in gravel‐bed streams using the virtual velocity approach: Insights from the North‐Western Himalayas, India
Authors: Yadav Anshul , Sen Sumit , Mao Luca , Hassan Marwan A. 
Published: June 2024

AbstractThis study focuses on evaluating the sediment mobility and transport patterns in two Himalayan rivers (Aglar and Paligad Rivers) during monsoon and non‐monsoon flows. The virtual velocity approach involving the measurements of the bed proportional mobility (Y), active layer depth (ds), displacement length and virtual velocity of mobilized grains was employed. Both local (0.5 m subsections) and wetted cross‐sectional average parameters were used. While using local parameters the total annual bed material transport was estimated to be 67 100 (±20 400 t) and 18 400 t (±6000 t) in the Aglar and Paligad Rivers, respectively. Of this, nearly 60% of transport occurred during the monsoon and the overall contribution of partial transport (PT) remained low (<6%). However, based on cross‐section average parameters, total transport was estimated to be 42 300 (±15 800 t) and 12 200 t (±4700 t), in Aglar and Paligad, respectively, with nearly 79% and 68% occurring during the monsoon. Moreover, the contribution of PT increased to nearly 18% and 29% for the Aglar and Paligad Rivers, respectively. Additionally, the dependence of PT on Y and full transport on ds results in an abrupt shift in transport rates at the transition from partial to full transport, causing discontinuity in transport curves. Therefore, a unified function was proposed to represent the extent of transport for both partial and full transport, yielding continuous transport curves. These findings are particularly relevant for efficient river management as the region houses several hydropower plants and is highly vulnerable to climate change.
Construction of organ of Corti organoid to study the effects of berberine sulfate on damaged auditory cells
Authors: Zhang Junming , Liu Li , Shen Rong , Lou Xiangxin 
Published: June 2024

AbstractSensorineural hearing loss (SNHL) is mainly caused by injury or loss of hair cells (HCs) and associated spiral ganglion neurons (SGNs) in the inner ear. At present, there is still no effective treatment for SNHL in clinic. Recently, advances in organoid bring a promising prospect for research and treatment of SNHL. Meanwhile, three‐dimensional (3D) printing provides a tremendous opportunity to construct versatile organoids for tissue engineering and regenerative medicine. In this study, gelatin (Gel), sodium alginate (SA), and polyvinyl alcohol (PVA) were used to fabricate biomimetic scaffold through 3D printing. The organ of Corti derived from neonatal mice inner ear was seeded on the PVA/Gel/SA scaffold to construct organ of Corti organoid. Then, the organ of Corti organoid was used to study the potential protective effects of berberine sulfate on neomycin‐juried auditory HCs and SGNs. The results showed that the PVA/Gel/SA biomimetic 3D scaffolds had good cytocompatibilities and mechanical properties. The constructed organoid could maintain organ of Corti activity well in vitro. In addition, the injury intervention results showed that berberine sulfate could significantly inhibit neomycin‐induced HC and SGN damage. This study suggests that the fabricated organoid is highly biomimetic to the organ of Corti, which may provide an effective model for drug development, cell and gene therapy for SNHL.