bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selecting effective divestments in electricity generation markets
Authors: Federico Giulio , López Ángel L. 
Published: December 2010

AbstractWe study the impact of electricity divestments in a stylised model where a dominant producer faces a competitive fringe with the same cost structure and is forced to sell some of its capacity. For a given demand level, the divestment which achieves the greatest reduction in prices can be several times more effective in reducing prices than a divestment of baseload (or low‐cost) plants. We extend this theoretical result to the case with variable electricity demand by considering a numerical example based on data from the Italian market. Copyright © 2010 John Wiley & Sons, Ltd.
Price‐based control of ancillary services for power balancing
Authors: van den Bosch P. P. J. , Jokic A. , Frunt J. , Kling W. L. , Nobel F. , Boonekamp P. , de Boer W. , Hermans R. M. , Virag A. 
Published: December 2010

AbstractA reliable and an efficient power system is a necessity for any industrialized society. Governments have to enforce regulations to guarantee that such a power system, in spite of many competing stakeholders, participants, companies, and regulating agencies can be operational. This paper analyzes the present arrangements and the future requirements to be posed on incentives and regulation for ancillary services (AS) for power balancing. The paper proposes companies to assess their own needs for AS. A two‐sided market for AS is being described to replace the existing arrangements for secondary control. The proposed solution guarantees a reliable and efficient operation of power systems in a market environment with responsive, reliable, and accountable but also competing prosumers, a large penetration of less‐predictable renewables and continent‐spanning transmission networks. Copyright © 2010 John Wiley & Sons, Ltd.
Instantaneous active and reactive current control technique of shunt active power filter based on the three‐level NPC inverter
Authors: Pouresmaeil Edris , Montesinos‐Miracle Daniel , Gomis‐Bellmunt Oriol , Sudrià‐Andreu Antoni 
Published: December 2010

AbstractIn this paper, the synthesis and performance of a shunt active power filter (SAPF) based on instantaneous active, and reactive current components (id − iq) technique is presented. The proposed active filter acts as a current source, which is connected in parallel with a nonlinear load and controlled to generate the required compensation currents. The proposed control technique for SAPF aims to compensate the harmonic current contents of nonlinear loads by connection of distributed generation (DG) resources based on renewable energy sources to distribution network. This modeling is derived from the 123(abc) to αβ and αβ to dq transformation of the ac system variables. The injected currents by the SAPF to polluted grid are controlled in synchronous orthogonal dq reference frame by using of decoupled current control technique. By use of phase locked loop (PLL) in control circuit of proposed technique, the angle of positive sequence has been detected, in order to synchronize the SAPF injected currents to distribution network. The proposed control strategy has this ability to eliminate wide range of harmonic frequency draws from utility grid, and provide the compensation currents by DG resources. By this control method, replacement of distributed power generation systems as an active power filter can be possible. Three‐phase three‐level neutral‐point‐clamped (NPC) voltage source inverter (VSI) is proposed for the interfacing between renewable energy resources and polluted distribution network. The simulation results demonstrate high performances of proposed SAPF technique. Copyright © 2010 John Wiley & Sons, Ltd.
Protein expression of cancer testis antigens predicts tumor recurrence and treatment response to imatinib in gastrointestinal stromal tumors
Authors: Perez Daniel , Hauswirth Fabian , Jäger Dirk , Metzger Urs , Samartzis Eleftherios Pierre , Went Philip , Jungbluth Achim 
Published: December 2010

AbstractCancer testis antigens (CTAs) have been identified in various tumors as immunological tumor targets. In gastrointestinal stromal tumor (GIST), the prediction of malignant potential remains difficult but is crucial in the era of adjuvant imatinib treatment. Here, we analyzed the impact of CTAs on tumor recurrence and its role on the treatment response to imatinib. The expression of the most frequent CTAs MAGE‐A1, MAGE‐A3, MAGE‐A4, MAGE‐C1 and NY‐ESO‐1 was analyzed by immunohistochemistry. The duration between the initial operation and the tumor relapse was defined as recurrence free survival (RFS). All recurrent cases were treated with imatinib. The tumor response to imatinib was graded according to the modified CT response evaluation criteria. Patients with a CTA positive GIST (n = 23, 27%) had a significantly shorter RFS (p = 0.001) compared to negative cases (n = 63, 73%). The median RFS was 25 months in CTA positive patients and was not reached during the study period in CTA negative patients. According to the established staging criteria CTA positive tumors were predominantly high‐risk tumors (p = 0.001). The expression of MAGE‐A3 (p = 0.018) and NY‐ESO‐1 (p = 0.001) were associated with tumor progression under imatinib treatment. A tendency for worse tumor response to imatinib was observed in CTA positive tumors (p = 0.056). Our study confirms the expression of CTAs in GIST and their role as prognostic markers. It also draws attention to the potential impact of CTAs on the tumor response to imatinib.
Effect of irrigation water and processing on the microbial quality of lettuces produced and sold on markets in Dakar (Senegal)
Authors: Ndiaye M.L. , Niang S. , Pfeifer H.‐R. , Peduzzi R. , Tonolla M. , Dieng Y. 
Published: December 2010

ABSTRACTThe aim of this survey is to assess the microbiological impact of irrigation water on lettuces produced on two urban agricultural sites and sold on markets; 6 and 7%, respectively, of lettuces coming from the sites of Pikine and Patte d'Oie were Salmonella spp. positive. Lettuces irrigated with shallow groundwater (“Céanes” water) were more contaminated (8% at both Pikine and Patte d'Oie sites) compared to those irrigated with wastewater (4% at Pikine) or well water (5% at Patte d'Oie). As for the lettuces in marketplaces, their contamination seems to depend on the type of treatment occurring before sale. Lettuces previously washed in the “Céanes” were more contaminated than those rinsed with tap water at the marketplace. Salmonella spp. have been isolated from all marketplaces. However, the rates of contamination in markets surrounding Patte d'Oie are higher (9 and 11% at Grand Yoff and Dalifort) than those surrounding Pikine (4 and 2% at Zinc and Sham) or Rufisque, the control (2%). Our results confirm that the reuse of wastewater in irrigation is an alternative to animal manure. Its risk of microbial contamination can be significantly reduced by washing the vegetables with tap water before they are sold. Copyright © 2010 John Wiley & Sons, Ltd.
Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins
Authors: Zhan Tianzuo , Digel Margarete , Küch Eva‐Maria , Stremmel Wolfgang , Füllekrug Joachim 
Published: December 2010

AbstractSilybin, the major flavonoid of Silybum marianum, is widely used to treat liver diseases such as hepatocellular carcinoma and cirrhosis‐associated insulin resistance. Research so far has focused on its anti‐oxidant properties. Here, we demonstrate that silybin and its derivative dehydrosilybin inhibit glucose uptake in several model systems. Both flavonoids dose‐dependently reduce basal and insulin‐dependent glucose uptake of 3T3‐L1 adipocytes, with dehydrosilybin showing significantly stronger inhibition. However, insulin signaling was not impaired, and immunofluorescence and subcellular fractionation showed that insulin‐induced translocation of GLUT4 to the plasma membrane is also unchanged. Likewise, hexokinase activity was not affected suggesting that silybin and dehydrosilybin interfere directly with glucose transport across the PM. Expression of GLUT4 in CHO cells counteracted the inhibition of glucose uptake by both flavonoids. Moreover, treatment of CHO cells with silybin and dehydrosilybin reduced cell viability which was partially rescued by GLUT4 expression. Kinetic analysis revealed that silybin and dehydrosilybin inhibit GLUT4‐mediated glucose transport in a competitive manner with Ki = 60 and 116 µM, respectively. We conclude that silybin and dehydrosilybin inhibit cellular glucose uptake by directly interacting with GLUT transporters. Glucose starvation offers a novel explanation for the anti‐cancer effects of silybin. J. Cell. Biochem. 112: 849–859, 2011. © 2010 Wiley‐Liss, Inc.
Task‐parallel message passing interface implementation of Autodock4 for docking of very large databases of compounds using high‐performance super‐computers
Authors: Collignon Barbara , Schulz Roland , Smith Jeremy C. , Baudry Jerome 
Published: December 2010

AbstractA message passing interface (MPI)‐based implementation (Autodock4.lga.MPI) of the grid‐based docking program Autodock4 has been developed to allow simultaneous and independent docking of multiple compounds on up to thousands of central processing units (CPUs) using the Lamarkian genetic algorithm. The MPI version reads a single binary file containing precalculated grids that represent the protein–ligand interactions, i.e., van der Waals, electrostatic, and desolvation potentials, and needs only two input parameter files for the entire docking run. In comparison, the serial version of Autodock4 reads ASCII grid files and requires one parameter file per compound. The modifications performed result in significantly reduced input/output activity compared with the serial version. Autodock4.lga.MPI scales up to 8192 CPUs with a maximal overhead of 16.3%, of which two thirds is due to input/output operations and one third originates from MPI operations. The optimal docking strategy, which minimizes docking CPU time without lowering the quality of the database enrichments, comprises the docking of ligands preordered from the most to the least flexible and the assignment of the number of energy evaluations as a function of the number of rotatable bounds. In 24 h, on 8192 high‐performance computing CPUs, the present MPI version would allow docking to a rigid protein of about 300K small flexible compounds or 11 million rigid compounds. © 2010 Wiley Periodicals, Inc. J Comput Chem, 2011
Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib
Authors: Irwin Mary E. , Mueller Kelly L. , Bohin Natacha , Ge Yubin , Boerner Julie L. 
Published: December 2010

AbstractEpidermal growth factor receptor (EGFR) is overexpressed in many cancer types including ∼30% of breast cancers. Several small molecule tyrosine kinase inhibitors (TKIs) targeting EGFR have shown clinical efficacy in lung and colon cancers, but no benefit has been noted in breast cancer. Thirteen EGFR expressing breast cancer cell lines were analyzed for response to EGFR TKIs. Seven were found to be EGFR TKI resistant; while shRNA knockdown of EGFR determined that four of these cell lines retained the requirement of EGFR protein expression for growth. Interestingly, EGFR localized to plasma membrane lipid rafts in all four of these EGFR TKI‐resistant cell lines, as determined by biochemical raft isolation and immunofluorescence. When lipid rafts were depleted of cholesterol using lovastatin, all four cell lines were sensitized to EGFR TKIs. In fact, the effects of the cholesterol biosynthesis inhibitors and gefitinib were synergistic. While gefitinib effectively abrogated phosphorylation of Akt‐ and mitogen‐activated protein kinase in an EGFR TKI‐sensitive cell line, phosphorylation of Akt persisted in two EGFR TKI‐resistant cell lines, however, this phosphorylation was abrogated by lovastatin treatment. Thus, we have shown that lipid raft localization of EGFR correlates with resistance to EGFR TKI‐induced growth inhibition and pharmacological depletion of cholesterol from lipid rafts decreases this resistance in breast cancer cell lines. Furthermore, we have presented evidence to suggest that when EGFR localizes to lipid rafts, these rafts provide a platform to facilitate activation of Akt signaling in the absence of EGFR kinase activity. J. Cell. Physiol. 226: 2316–2328, 2011. © 2010 Wiley‐Liss, Inc.
Delay in treatment of early‐stage hepatocellular carcinoma using radiofrequency ablation may impact survival of cirrhotic patients in a surveillance program
Authors: Chen Wei‐Ting , Fernandes Mark Lee , Lin Chen‐Chun , Lin Shi‐Ming 
Published: December 2010

AbstractBackgroundThe aim of this study was to evaluate the impact of the interval between diagnosis and treatment using radiofrequency (RF) ablation on the survival of patients with HCC detected through a surveillance program.MethodsBetween January 2004 and July 2007, 121 cirrhotic patients with 157 tumours detected through a surveillance program underwent RF ablation. A delay in treatment was defined as >5 weeks. The mean length of follow‐up was 25 months (range 8–55 months). Cumulative survival of patients was analysed using the Kaplan–Meier method. Cox regression models were used to identify factors associated with patient survival.ResultsThe 1‐, 2‐ and 3‐year survival rates were 92.5%, 78.5% and 67.2%. The independent predictors of poorer patient survival were time from diagnosis to treatment >5 weeks (pooled odds ratio [OR], 3.59; 95% confidence interval [CI], 1.58–8.18; P = 0.002), absence of complete ablation after the initial RF session (OR, 2.42; 95% CI 1.07–5.45; P = 0.033) and Child‐Pugh B liver cirrhosis (OR, 2.46; 95% CI 1.06–5.70; P = 0.036).ConclusionsDelay in the start of effective treatment for HCC using RF ablation may be associated with poorer patient survival. J. Surg. Oncol. 2011; 103:133–139. © 2010 Wiley‐Liss, Inc.
Evaluation of the effects of type II radical hysterectomy in the treatment of 960 patients with stage IB–IIB cervical carcinoma: A retrospective study
Authors: Zheng Min , Huang Long , He Li , Ding Hui , Wang Hui‐Yun , Zheng Li‐Min 
Published: December 2010

AbstractBackground and ObjectivesThis retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB–IIB cervical cancer with or without high‐risk factors.MethodsA total of 960 stage IB–IIB patients who underwent type II radical hysterectomies between 1995 and 2004 were enrolled and retrospectively analyzed.ResultsUterine corpus invasion, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors for stage IB patients. For stage IIA–IIB patients, histologic type, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors. The 5‐year overall survival (OS) rates for patients with stage IB versus stage IIA–IIB cervical carcinomas were 88.4% and 78.5%, respectively. Moreover, adjuvant radiotherapy and chemotherapy improved the 5‐year OS rates of stage IIA–IIB patients associated with high‐risk factors. The overall recurrence rate for this cohort was 14.4%.ConclusionsOur findings show that type II radical hysterectomy is a feasible treatment option for stage IB–IIB cervical carcinoma patients. Furthermore, type II radical hysterectomy combined with adjuvant post‐operative therapy improves the OS of women with high‐risk factors for cervical carcinoma. J. Surg. Oncol. 2011; 103:435–441. © 2010 Wiley‐Liss, Inc.
Information seeking behaviors of parents whose children have life‐threatening illnesses
Authors: Knapp Caprice , Madden Vanessa , Marcu Mircea , Wang Hua , Curtis Charlotte , Sloyer Phyllis , Shenkman Elizabeth 
Published: December 2010

AbstractObjectivesFor children with life‐threatening illnesses we sought to (1) understand the associations between parental characteristics and preferred health information sources, and (2) assess the e‐health literacy of Internet‐users.Study DesignCross‐sectional, telephone survey of 129 parents whose children are in a pediatric palliative care program in Florida.ResultsFour out of five parents report that they use the Internet, and 64% of Internet‐users use it daily. Parents who never use the Internet, versus parents who do use the Internet, are predominately Hispanic (50%) and have less than a high school education (64%) (P ≤ 0.023). Internet‐users have high levels of e‐health literacy; however, they are not confident or are unsure about the quality of information on the Internet. Not having graduated from high school was associated with a decrease in e‐health literacy and using the Internet as the primary information source (vs. doctor as primary source) was associated with an increase in e‐health literacy.ConclusionParents of children with life‐threatening illnesses have access to and use the Internet as a source of information about their children's health. More information is needed to explore how electronic‐based interventions could be used to impact information seeking of parents whose children are in pediatric palliative care programs. Pediatr Blood Cancer 2011;56:805–811. © 2010 Wiley‐Liss, Inc.
Cancer risk with tumor necrosis factor alpha (TNF) inhibitors: meta‐analysis of randomized controlled trials of adalimumab, etanercept, and infliximab using patient level data
Authors: Askling Johan , Fahrbach Kyle , Nordstrom Beth , Ross Susan , Schmid Christopher H. , Symmons Deborah 
Published: December 2010

AbstractPurposeUncertain short‐ and long‐term cancer risks with anti‐TNF therapies is a concern, and led to a recent black box warning. This meta‐analysis, requested by the European Medicines Agency, aimed at better assessing short‐term risks by using meta‐analytic techniques based on individual patient data from all corporate‐sponsored randomized controlled trials (RCTs) of adalimumab, etanercept, and infliximab.MethodsAll 74 RCTs of TNF inhibitors of at least 4 weeks duration were provided to independent investigators, including case narratives for events occurring between trial start until 30 days after planned end of treatment and indicating a possible cancer. Relative risks were estimated using Bayesian piecewise exponential models.ResultsOne hundred thirty (0.84%) of 15 418 individuals randomized to anti‐TNF therapy were diagnosed with cancer, compared to 48 (0.64%) of 7486 individuals randomized to comparators. The relative risks associated with all anti‐TNF were 0.99 (95%CI 0.61–1.68) for cancers excluding non‐melanoma skin cancer (NMSC), and 2.02 (95%CI 1.11–3.95) for NMSC. There were indications of differences in the relative risks for the three anti‐TNF drugs, but also of differences across the cancer rates in the three comparator arms for adalimumab, etanercept, and infliximab.ConclusionsDespite a reassuring overall short‐term risk, we could neither refute nor verify that individual anti‐TNF therapies affect the short‐term clinical emergence of cancer. Despite representing the best available evidence, statistical precision, and differences in baseline cancer risk and reporting detail between trials of adilumumab, etanercept, and infliximab hampered distinction of drug‐specific from trial effects, illustrating the challenges in safety‐assessments using RCT meta‐analyses. Long‐term risk assessment requires observational studies. Copyright © 2010 John Wiley & Sons, Ltd.
An exploratory analysis of the NEO‐FFI and DSM personality disorders using multivariate canonical correlation
Authors: Aboaja Anne , Duggan Conor , Park Bert 
Published: December 2010

AbstractIt has been argued that some of the difficulties in the Diagnostic and Statistical Manual of Mental Disorders (DSM) personality disorders might be overcome by examining their association with measures of general personality such as the Neuroticism, Extroversion and other Five‐Factor Inventory (NEO‐FFI) model. The study explored associations between the NEO‐FFI and DSM personality disorder in 85 male offenders referred to a personality disorder unit. Although simple correlation showed the expected associations, multivariate canonical correlation revealed more complex and novel associations such as the finding that borderline personality disorder has a more robust conceptual relationship than antisocial personality disorder with the NEO‐FFI. Overall, the NEO‐FFI can be used to conceptualize most DSM personality disorders. Copyright © 2010 John Wiley & Sons, Ltd.
The mechanism of aromatic nucleophilic substitution reaction between ethanolamine and fluoro‐nitrobenzenes: an investigation by kinetic measurements and DFT calculations
Authors: Jose K.B. , Cyriac J. , Moolayil J. T. , Sebastian V.S. , George M. 
Published: December 2010

AbstractWe have studied the kinetics and elucidated the mechanism by DFT calculation of the reaction between ethanolamine (EOA) and 1‐fluoro‐2,4‐dinitrobenzene (DNFB) in acetonitrile and toluene. To determine the contribution of the nitro group, the activation energy of the reaction between ethanolamine and 1‐fluoro‐2‐nitrobenzene (MNFB) vs. DNFB was determined in acetonitrile and calculated by DFT method. Kinetic measurements reveal that the reaction is faster in acetonitrile than in toluene. The reaction follows overall second‐order kinetics: first order with respect to both EOA and DNFB which is similar to the results reported for reaction between other primary amines and 1‐substituted‐2,4‐dinitrobenzenes. The calculations by using DFT methods reveal that the mechanism of the reaction involves the formation and decomposition of a Meisenheimer complex (MC). DFT calculations also reveal that the activation energy of the reaction is highest in vacuum and decreases with increasing polarity of the solvent reaching a minimum in acetonitrile. In addition, activation energies obtained by both DFT calculations and experiments show that the reactivity of MNFB is less than that of DNFB showing the effect of the 4‐nitro group. Copyright © 2010 John Wiley & Sons, Ltd.
Pd(0)‐catalyzed polycondensation of aryl‐substituted propargylic carbonates with bifunctional nucleophiles promoted by aryl group on the acetylenic terminal carbon
Authors: Nishioka Noriyuki , Koizumi Toshio 
Published: December 2010

AbstractA Pd(0)‐catalyzed polycondensation of bifunctional nucleophiles and propargylic carbonates having an aryl group was investigated. The polycondensation was carried out for tetrahydrofuran at 60 °C for 3 h in the presence of Pd(0) catalyst. The Pd(0)‐catalyzed polycondensation of phenyl‐substituted propargylic carbonates and nucleophiles proceeded efficiently, when bis[(2‐diphenylphosphino)phenyl]ether was used as the ligand. We found that the position of the phenyl group was crucial for the successful polycondensation. The introduction of a phenyl group on the acetylenic terminal carbon remarkably promoted the polycondensation and afforded high molecular weight polymers. On the other hand, a phenyl group at the propargylic position was not effective. Propargylic carbonates having a substituted phenyl group were also examined. Electron‐withdrawing group‐substituted phenyl groups on the acetylenic terminal carbon were found to be more effective for the polycondensation. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Excitons in a cylindrical GaAs Pöschl–Teller quantum dot
Authors: Mora‐Ramos M. E. , Barseghyan M. G. , Duque C. A. 
Published: December 2010

AbstractThe exciton binding energy in a cylindrical quantum dot (QD) with Pöschl–Teller confining potential is studied with the use of the effective mass approximation and a variational calculation procedure. A GaAs prototype structure is particularly considered and both the spatially‐direct (DE) and spatially‐indirect (IE) exciton regimes are taken into account. We show that there is a significant effect of the Pöschl–Teller quantum well (QW) symmetry profile on the exciton properties in both configurations.