bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equilibrium and kinetic investigation of the interaction of model palladium(II) complex with biorelevant ligands
Authors: Shoukry Mohamed M. , Shoukry Azza A. , Khalf Alla Perihan A. , Hassan Safaa S. 
Published: July 2010

AbstractPd(DME)Cl2 complex was synthesized and characterized, where DME is 2‐{[2‐(dimethylamino)ethyl]‐methylamino}ethanol. Stoichiometry and stability constants of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents, and dicarboxylic acids) and [Pd(DME)(H2O)2]2+ are investigated at 25°C and at constant 0.1 M ionic strength. The effect of dielectric constant of the medium on the stability constant of Pd(DME)‐CBDCA complex, where CBDCA is cyclobutanedicarboxylate, is also reported. The concentration distribution diagrams of the various species formed are evaluated. The kinetics of base hydrolysis of amino acid esters coordinated to Pd(DME)2+ complex is investigated. The effect of the temperature on the kinetics of base hydrolysis of glycine methyl ester complex is studied. © 2010 Wiley Periodicals, Inc. Int J Chem Kinet 42: 608–618, 2010
Some considerations on functional differential equations of advanced type
Authors: Nieto Juan J. , Rodríguez‐Löpez Rosana 
Published: July 2010

AbstractWe prove some comparison results for the periodic boundary value problem related to a first‐order functional differential equation of advanced type. These maximum principles provide uniqueness results for nonlinear differential equations with advanced arguments. By a change of variable, we deduce analogous results for fuctional differential equations with delayed arguments (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Cylinder Homomorphisms and Chow Groups
Authors: Lewis James D. 
Published: July 2010

AbstractLet X be a projective algebraic manifold of dimension n (over C), CH1(X) the Chow group of algebraic cycles of codimension l on X, modulo rational equivalence, and A1(X) ⊂ CH1(X) the subgroup of cycles algebraically equivalent to zero. We say that A1(X) is finite dimensional if there exists a (possibly reducible) smooth curve T and a cycle z∈CH1(Γ × X) such that z*:A1(Γ)‐A1(X) is surjective. There is the well known Abel‐Jacobi map λ1:A1(X)‐J(X), where J(X) is the lth Lieberman Jacobian. It is easy to show that A1(X)→J(X)
equation image
A1(X) finite dimensional. Now set
equation image
with corresponding map A*(X)→J(X). Also define Level
equation image
. In a recent book by the author, there was stated the following conjecture:
equation image
where it was also shown that (⟹) in (**) is a consequence of the General Hodge Conjecture (GHC). In this present paper, we prove A*(X) finite dimensional ⇔︁ Level (H*(X)) ≤ 1 for a special (albeit significant) class of smooth hypersurfaces. We make use of the family of k‐planes on X, where
equation image
([…] = greatest integer function) and d = deg X; moreover the essential technical ingredients are the Lefschetz theorems for cohomology and an analogue for Chow groups of hypersurfaces. These ingredients in turn imply very special cases of the GHC for our choice of hypersurfaces X. Some applications to the Griffiths group, vanishing results, and (universal) algebraic representatives for certain Chow groups are given.
Imaging amyloid in Parkinson's disease dementia and dementia with Lewy bodies with positron emission tomography
Authors: Brooks David J. 
Published: July 2010

AbstractAlthough Parkinson's disease with later dementia (PDD) and dementia with Lewy bodies (DLB) are pathologically characterized by the presence of intraneuronal Lewy inclusion bodies, amyloid deposition is also associated to varying degrees with both these disorders. Fibrillar amyloid load can now be quantitated in vivo with positron emission tomography (PET) using imaging biomarkers. Here the reported findings of 11C‐PIB PET studies concerning the amyloid load associated with PD and its influence on dementia are reviewed. It is concluded that the presence of amyloid acts to accelerate the dementia process in Lewy body disorders, though has little influence on its nature. Anti‐amyloid strategies could be a relevant approach for slowing dementia in a number of DLB and PDD cases. © 2009 Movement Disorder Society
Assessing disease progression with MRI in atypical parkinsonian disorders
Authors: Köllensperger Martin , Wenning Gregor K. 
Published: July 2010

AbstractDuring the last decade, novel MR techniques have become available to support the early differential diagnosis of Parkinsonism and also to generate MR surrogate markers of disease progression. The article reviews the current state of the art focusing on three atypical parkinsonian disorders: multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and dementia with Lewy bodies (DLB). © 2009 Movement Disorder Society
Clinical measures of progression in Parkinson's disease
Authors: Poewe Werner 
Published: July 2010

AbstractDespite all recent advances in symptomatic therapy Parkinson's disease (PD) continues to be a relentlessly progressive neurodegenerative disorder. Therefore therapies that will slow or hold disease progression are a major medical unmet need in PD. Clinical measures of disease progression that have been used in disease modification trials so far have focused on indices of progression of cardinal motor features like bradykinesia, rigidity, and tremor as captured by the UPDRS and the emerging need for effective dopaminergic symptomatic therapy. Progression of global disability in PD, however, is driven by additional factors beyond progressive nigrostriatal denervation leading to increasing severity of cardinal motor features. Progressive pathology in extranigral sites in the brain or peripheral autonomic nervous system contribute to poorly levodopa responsive motor symptoms like postural instability, freezing and falls or nonmotor symptoms. In addition treatment‐induced motor complications also impact on PD disability. Although it is widely accepted that clinical progression of PD is multidimensional and in addition includes effects of aging, there is no consensus how to best implement more clinically meaningful endpoints for disease progression trials that would reflect these complex interactions impacting on the evolution of global disability in PD. There is an urgent need for biomarkers for disease progression that would faithfully reflect advancing neurodegeneration and resulted clinical disability in PD and that could be used in shorter term clinical trials testing putative disease modifying agents. © 2009 Movement Disorder Society
Mapping preclinical compensation in Parkinson's disease: An imaging genomics approach
Authors: van Nuenen Bart F.L. , van Eimeren Thilo , van der Vegt Joyce P.M. , Buhmann Carsten , Klein Christine , Bloem Bastiaan R. , Siebner Hartwig R. 
Published: July 2010

AbstractMutations in the Parkin (PARK2) and PINK1 gene (PARK 6) can cause recessively inherited Parkinson's disease (PD). The presence of a single Parkin or PINK1 mutation is associated with a dopaminergic nigrostriatal dysfunction and conveys an increased risk to develop PD throughout lifetime. Therefore neuroimaging of non‐manifesting individuals with a mutant Parkin or PINK1 allele opens up a window for the investigation of preclinical and very early phases of PD in vivo. Here we review how functional magnetic resonance imaging (fMRI) can be used to identify compensatory mechanisms that help to prevent development of overt disease. In two separate experiments, Parkin mutation carriers displayed stronger activation of rostral supplementary motor area (SMA) and right dorsal premotor cortex (PMd) during a simple motor sequence task and anterior cingulate motor area and left rostral PMd during internal movement selection as opposed to externally cued movements. The additional recruitment of the rostral SMA and right rostral PMd during the finger sequence task was also observed in a separate group of nonmanifesting mutation carriers with a single heterozygous PINK1 mutation. Because mutation carriers were not impaired at performing the task, the additional recruitment of motor cortical areas indicates a compensatory mechanism that effectively counteracts the nigrostriatal dysfunction. These first results warrant further studies that use these imaging genomics approach to tap into preclinical compensation of PD. Extensions of this line of research involve fMRI paradigms probing nonmotor brain functions. Additionally, the same fMRI paradigms should be applied to nonmanifesting mutation carriers in genes linked to autosomal dominant PD. This will help to determine how “generically” the human brain compensates for a preclinical dopaminergic dysfunction. © 2009 Movement Disorder Society
Potential role of high‐field MRI for studies in Parkinson's disease
Authors: Schuff Norbert 
Published: July 2010

AbstractRecent advancements in high field magnetic resonance imaging (MRI) technology (3 T and higher), providing increased signal sensitivity and images with more prominent contrasts intrinsic to the brain, offer new opportunities for assessing brain alterations in Parkinson's disease (PD). In this article, the principle benefits of high field MRI for PD research are described and new findings at high magnetic fields are reviewed. Several high field MRI methodologies, including structural MRI, imaging of brain iron, diffusion tensor imaging, arterial spin labeling perfusion imaging, rotating frame imaging, and magnetic resonance spectroscopy, are critically reviewed for their potential roles in studies of PD. © 2009 Movement Disorder Society
Potential of advanced MR imaging techniques in the differential diagnosis of parkinsonism
Authors: Hotter Anna , Esterhammer Regina , Schocke Michael F.H. , Seppi Klaus 
Published: July 2010

AbstractThe clinical differentiation of parkinsonian syndromes remains challenging not only for neurologists but also for movement disorder specialists. Conventional magnetic resonance imaging (cMRI) with the visual assessment of T2‐ and T1‐weighted imaging as well as different advanced MRI techniques offer objective measures, which may be a useful tool in the diagnostic work‐up of Parkinson's disease and atypical parkinsonian disorders (APDs). In clinical practice, cMRI is a well‐established method for the exclusion of symptomatic parkinsonism due to other pathologies. Over the past two decades, abnormalities in the basal ganglia and infratentorial structures have been shown especially in APDs not only by cMRI but also by different advanced MRI techniques, including methods to assess regional cerebral atrophy quantitatively such as magnetic resonance volumetry, proton magnetic resonance spectroscopy, diffusion‐weighted imaging, and magnetization transfer imaging. This article aims to review recent research findings on the role of advanced MRI techniques in the differential diagnosis of neurodegenerative parkinsonian disorders. © 2009 Movement Disorder Society
PDD‐Short Screen: A brief cognitive test for screening dementia in Parkinson's disease
Authors: Pagonabarraga Javier , Kulisevsky Jaime , Llebaria Gisela , García‐Sánchez Carmen , Pascual‐Sedano Berta , Martinez‐Corral Mercè , Gironell Alexandre 
Published: July 2010

AbstractThe diagnosis of Parkinson's disease with dementia (PDD) is currently based on clinical criteria (DSM‐IV, MDS–Task Force). In daily practice and research studies, these criteria still depend on the subjective impression of the examiner. Brief screening tests (BST) are helpful in identifying patients with PD with dementia, which can be difficult in patients with advanced PD. We aimed to develop a BST for PD, the PDD‐Short Screen (PDD‐SS), to accurately and quickly screen for PDD. In this prospective study, 70 patients with nondemented (age 73.8 ± 4.4) and 32 demented (age 73.8 ± 4.4) PD regularly attending a Movement Disorders Clinic were included. Diagnosis of dementia was based on DSM‐IV criteria, CDR score ≥1, and PD‐CRS total score ≤64. The PDD‐SS, Mattis Dementia Rating Scale (MDRS), and Mini‐Mental State Examination (MMSE) were administered to all participants. Validity, reliability, and discriminative power of the PDD‐SS were examined. The final version of the scale included the items immediate and delayed verbal memory, clock drawing, alternating verbal fluency, and a questionnaire covering cognitive and psychiatric (hallucinations, apathy) symptoms common in PDD. A cutoff score ≤11 on the PDD‐SS yielded high sensitivity (89.8%) and specificity (88.5%) for diagnosing PDD. The MDRS displayed similar accuracy, but the PDD‐SS administration time was significantly shorter (4.8–6.9 vs. 17.5–25.2 minutes). Diagnosis of dementia using the PDD‐SS was not influenced by age, education, or motor function. The PDD‐SS appears as the first BST for diagnosing PDD, displays an excellent diagnostic accuracy, and takes 5 to 7 minutes to be administered. © 2010 Movement Disorder Society
Erratum: Neural network approach to determine nonsmooth one‐dimensional profiles in inverse scattering theory
Authors: Yaman Fatih , Şimc̈ek Serkan 
Published: July 2010

AbstractOriginally published Microwave Opt Technol Lett 49 (2007), 3158–3162. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 549, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23138
An Efficient Implementation of Joint Fourier Transform Correlation Using a Modified LCTV
Authors: Perez O. , Karim M. A. 
Published: July 2010

AbstractThe joint Fourier transform correlation (JFTC) algorithm is implemented using a modified Citizen liquid crystal television (LCTV) which acts as a spatial light modulator in the amplitude mode. Using a combination of optics and electronics, results are obtained in real time (1/30 of a second). The video output is introduced into a video processing system to eliminate the noise inherent when using a coherent, monochromatic source. An optical disk is used to eliminate the dc term in the correlation plane and obtain only the correlation peaks.
A Space Factor Zero Placement Technique for the Synthesis of Subarrayed Monopulse Linear Arrays
Authors: Mcnamara Derek A. 
Published: July 2010

AbstractIn this paper a technique is described to simultaneously synthesize both sum and difference patterns of linear antenna arrays which utilize subarraying to increase the number of degrees of freedom above that Obtainable with the more conventional two‐section feed network. The approach described attempts to obtain an optimum sum (difference) and a “best compromise” difference (sum) pattern by dealing directly with the space factor zeros of the separately optimum sum and difference patterns and appropriately adjuring the subarray weights.
An Efficient Partial Differential Equation Technique for Solving the Problem of Scattering by Objects of Arbitrary Shape
Authors: Kheblr A. , Ramahl O. , Mittra R. 
Published: July 2010

AbstractThe solution of an open region scattering problem using partial differential equation techniques usually requires enclosing the scatterer by a circular outer boundary and applying an absorbing boundary condition at this boundary. For a long slender scatterer, a circular outer boundary necessitates a very large mesh region which results in a large matrix. In this paper, we introduce a generalized boundary condition that is appropriate for an arbitrary outer boundary that conforms to the shape of the scatterer. In order 10 demonstrate the potentiality of the method, two different scatterer shapes are studied The solutions are found to agree well with those derived via the method of moments.
Experimental Study of the Microwave Impedance of Resonant Tunneling Diodes
Authors: Lippens Didler , Vanksien Olivier 
Published: July 2010

AbstractThe microwave impedance of high current Al0.3 Ga0.7 As‐GaAs‐Al0.3 Ga0.7 As resonant tunneling diodes is measured from 0.1 to 12.1 GHz over a large bias range at 300 K. Using an equivalent circuit model, the bias dependence of intrinsic conductance and capacitance suffice to explain the pronounced variations of impedance.
Photoresponse Of Gaas Mesfet Inverters By Pulsed Laser Illumination
Authors: Leietad J. E. , Fjeldly T. A. 
Published: July 2010

AbstractBy applying sufficiently high pulsed optical power to the input transistor of a GaAs BFL inverter, it is possible to generate a complete logic transition at the inverter output with the input transistor biased in cutoff The observation is explained in terms of photogenerated current flowing in the drain‐gate circuit of the input MESFET. A logic transition takes place when the photocurrent saturates the load transistor for a time interval exceeding the switching time of the output circuit.
An Adaptive Optical Neural Network Using A High Resolution Video Monitor
Authors: Wu Shudong , Lu Taiwei , Xu Xin , Yu Francis T. S. 
Published: July 2010

AbstractAn adaptive hybrid optical neural network using a high resolution video monitor as a programmable associative memory is proposed. This architecture is capable of implementing larger numbers of neurons with higher dynamic range. The proposed system can be operated in a high speed asynchronous mode with parallel feedback loop. The orthogonal projection algorithm as applied to the proposed system to increase the error correction ability is given.
A Simple Model Of Thick Strips In Anisotropic Multilayered Dielectric Media
Authors: Plaza G. , Marqués R. , Horno M. 
Published: July 2010

AbstractA theoretical model is presented for the analysis of microstrip multiconductor structures embedded in anisotropic lossless nonmagnetic multilayered dielectric media with finite strip thickness. The model reduces the thick conductor problem to the thin strip case. Calculations are made in the spectral domain. Numerical results are given and compared with published data.
Efficient Calculation Of Propagation Delays In The Vlsi Multilevel Interconnections
Authors: Goel A. K. 
Published: July 2010

AbstractWe have developed a computer‐efficient algorithm and carried out computer simulations on the single propagation and the delays in the multilevel high density interconnections on the GaAs‐based VLSICs. The algorithm has been used to study the dependence of the load voltage waveforms and delay times on the various interconnection parameters.
Role of computed tomography scanning in the management of Ewing's sarcoma
Authors: Williams Michael P. , Husband Janet E. , McElwain T. J. 
Published: July 2010

AbstractIt is well established when imaging patients with primary bone malignancy that on occasions computed tomography (CT) scanning can offer unique information. It is less clear, however, in what circumstances this information will lead to a change in patient management. This study reviewed the results of CT examinations in 32 patients with Ewing's sarcoma and examined the influence of CT on patient management in different clinical circumstances. CT provided new information on a total of 75 occasions out of 153 examinations. Management was changed on 17 occasions as a direct result of the CT scan findings. Overall, 50% of patients had their management altered as a result of CT. Follow‐up CT scans in the chest more frequently influenced patient management than did either staging or follow‐up scans of the primary site.
Second malignant neoplasms following childhood Hodgkin's disease: Treatment and splenectomy as risk factors
Authors: Meadows Anna T. , Obringer Angela C. , Marrero Osvaldo , Oberlin Odile , Robison Leslie , Fossati‐Bellani Franca , Green Daniel , Voǔte P. A. , Morris‐Jones Patricia , Greenberg Mark , Baum Edward , Ruymann Frederick 
Published: July 2010

AbstractThe risk of second malignant neoplasm (SMN) was evaluated in 979 children with Hodgkin's disease. This cohort was diagnosed between 1955 and 1979 at one of the institutions of the Late Effects Study Group. Solid tumors, non‐lymphocytic leukemia, and non‐Hodgkin's lymphoma (NHL) developed in 18, 17, and 3 patients, respectively. The estimated cumulative probability of developing any SMN was 2% at 5 years from diagnosis, 5% at 10 years, and 9% at 15 years. The incidence is ninefold greater than the risk of acquiring cancer in 19 year‐olds, the median age at which the diagnosis of SMN was made in this study population.For leukemia and NHL the corresponding probabilities were 1%, 3%, and 4% for the group as a whole but were increased (2%, 6%, and 8%) in patients who had suffered one or more recurrences. In order to analyze the risk of leukemia and NHL associated with alkylating agent chemotherapy, each patient was assigned a score of one for each alkylating agent administered for a 6‐month period. Scores of 2, 4, 6, and 8 were associated with probabilities of leukemia or NHL of 2%, 3%, 6%, and 10%, respectively. In a multivariate analysis for leukemia/lymphoma that included AAD score, stage, and splenectomy, the effect of AAD score and splenectomy did not change substantially compared to the univariate results. AAD score remained statistically significant (P = .0001), and splenectomy was of borderline significance (P = .09).Ot the 18 solid tumor SMNs, 15 developed within the field of radiation, and one other developed in tissue irradiated 34 years earlier for hemangioma.This study of a large and unselected group of children with Hodgkin's disease who received a variety of therapies demonstrates that children are as likely as adults to develop acute leukemia after alkylating agents and solid tumors in the field of radiation therapy.
Tryptamine derived amides with thiazole ring system from Thermoactinomyces strain TA66‐2
Authors: Korkmaz Çaǧla Akmemiş , Hameş‐Kocabaş E. Esin , Uzel Ataç , Bedir Erdal 
Published: July 2010

AbstractA moderately thermophilic actinomycete strain, which was identified as Thermoactinomyces strain TA66‐2, was isolated from hot‐spring water. Fermentation, followed by solvent partition and chromatographic separations, resulted in the isolation of two new and two known molecules. The structures of the new compounds were elucidated as 2‐(1‐Propionylaminoethyl)thiazole‐4‐carboxylic acid [2‐(1H‐indol‐3‐yl)ethyl]amide and 2‐(1‐Acetylaminoethyl)thiazole‐4‐carboxylic acid [2‐(1H‐indol‐3‐yl)‐ethyl]amide by using spectral methods (1D‐, 2D‐NMR and LC–ESI–MS). Copyright © 2007 John Wiley & Sons, Ltd.
13C isotope effects on 1H chemical shifts: NMR spectral analysis of 13C‐labelled D‐glucose and some 13C‐labelled amino acids
Authors: Tiainen Mika , Maaheimo Hannu , Soininen Pasi , Laatikainen Reino 
Published: July 2010

AbstractThe one‐ and two‐bond 13C isotope shifts, typically −1.5 to −2.5 ppb and −0.7 ppb respectively, in non‐cyclic aliphatic systems and up to −4.4 ppb and −1.0 ppb in glucose cause effects that need to be taken into account in the adaptive NMR spectral library‐based quantification of the isotopomer mixtures. In this work, NMR spectral analyses of some 13C‐labelled amino acids, D‐glucose and other small compounds were performed in order to obtain rules for prediction of the 13C isotope effects on 1H chemical shifts. It is proposed that using the additivity rules, the isotope effects can be predicted with a sufficient accuracy for amino acid isotopomer applications. For glucose the effects were found strongly non‐additive. The complete spectral analysis of fully 13C‐labelled D‐glucose made it also possible to assign the exocyclic proton signals of the glucose. Copyright © 2009 John Wiley & Sons, Ltd.