bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pluviometric gradient incidence and the hydrological behaviour of soil surface components (southern Spain)
Authors: Ruiz Sinoga J. D. , Garcia Marín R. , Martínez‐Murillo J. F. , Gabarrón Galeote M. A. 
Published: May 2010

AbstractThe hydrological response of Mediterranean hillslopes depends on the type of soil surface components (SSC) which is controlled by the strongly climate. Along a Mediterranean climatic gradient, the type of soil surface component is modified as the aridity increases: biotic ones (annual plants, litter, moss and lichens) used to be more significant under humid climatic conditions, whereas abiotic ones (crusts, rock fragments and outcrops), under semiarid conditions. The aim of the study is to analyse the hydrological behaviour of different types of SSC in three field sites under different Mediterranean climatic conditions to (1) confirm whether the pluviometric gradient factor affects their hydrological response, and (2) whether, in each field site, SSC play the same role as controlling factors of infiltration processes. The method is based on grouping explanatory variables (related to precipitations, topography, vegetal cover, soil moisture and some soil physical, chemical and hydrological properties) through factorial analysis being applied for both regional and local approaches. The results confirm that the type of soil surface component acts as regulator of soil hydrological processes along the pluviometric gradient as well as at every field site, and show that the role played by the type of soil surface component is a much more significant key‐factor for the hydrological response of soils under dry‐Mediterranean climatic conditions. Copyright © 2010 John Wiley & Sons, Ltd.
Comparison of quantitative parameters in cervix cancer measured by dynamic contrast–enhanced MRI and CT
Authors: Yang Cheng , Stadler Walter M. , Karczmar Gregory S. , Milosevic Michael , Yeung Ivan , Haider Masoom A. 
Published: May 2010

AbstractCervical tumors of 38 cervix cancer patients were scanned by T1‐weighted dynamic contrast enhanced (DCE) MRI and then by DCE‐CT on the same day. Gadodiamide and iohexol were respectively used as the low‐molecular‐weight contrast agent in DCE‐MRI and DCE‐CT. Under an extended Tofts model, DCE‐MRI data were analyzed using either individual arterial input functions estimated by a multiple reference tissue method or a population arterial input function by Parker et al., whereas DCE‐CT data were analyzed using the arterial input function directly measured from the external iliac arteries. The derived quantitative parameters of cervical tumors were compared between DCE‐MRI and DCE‐CT. When using the individual multiple reference tissue method arterial input functions to analyze the DCE‐MRI data, the correlation coefficients between DCE‐MRI‐ and DCE‐CT‐derived parameters were, respectively, back‐flux rate constant (r = 0.80), extravascular extracellular fractional volume (r = 0.73), contrast agent transfer rate (r = 0.62), and blood plasma volume (r = 0.32); when using the Parker population arterial input function, the correlation coefficients were back‐flux rate constant (r = 0.79), extravascular extracellular fractional volume (r = 0.77), contrast agent transfer rate (r = 0.63), and blood plasma volume (r = 0.58). Tumor parametric maps derived by DCE‐MRI and DCE‐CT had very similar morphologies. However, the means of most derived quantitative parameters were significantly different between the two imaging methods. Close correlation of quantitative parameters derived from two independent imaging modalities suggests both are measuring similar tumor physiologic variables. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
Manganese‐enhanced MRI of salivary glands and head and neck tumors in living subjects
Authors: Seshadri Mukund , Hoy Allison 
Published: May 2010

AbstractManganese‐enhanced MRI has previously been used for visualization of brain architecture and functional mapping of neural pathways. The present work investigated the potential of manganese‐enhanced MRI for noninvasive imaging of salivary glands in living subjects. Marked shortening of T1 was observed in salivary glands of naïve mice (n = 5) 24–48 h after systemic administration of MnCl2 (0.4 mmol/kg, intraperitoneally). Three‐dimensional MR microscopy confirmed selective contrast enhancement of salivary gland tissues post–MnCl2 injection. Ectopic and orthotopic head and neck tumor xenografts also showed an increase in R1 at 24 h following MnCl2 injection (0.2 mmol/kg, intraperitoneally). However, tumor enhancement was minimal compared to salivary gland tissue. Salivary gland R1 values were lower in mice bearing orthotopic head and neck tumors compared to naïve mice. These results demonstrate, for the first time, the usefulness of manganese‐enhanced MRI in the visualization of salivary glands and head and neck tumors in vivo. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
”Für unsere schöne Wissenschaft eine Einigung anzubahnen“
Authors: Mönnich Michael 
Published: May 2010

AbstractKongresse sind auch im Zeitalter von Internet und E‐Mail eine wichtige und beliebte Form der Kommunikation innerhalb einer wissenschaftlichen Disziplin. Die Chemie kann auf eine 150‐jährige Tradition zurückblicken: Der erste internationale Chemikerkongress fand vom 3. bis 5. September 1860 in Karlsruhe statt.
Die obersten Schichten genau im Blick
Authors: Nehm Rainer 
Published: May 2010

AbstractDie noch junge RF‐GD‐TOF‐Massenspektrometrie charakterisiert die Oberflächenschichten von Polymeren, Stählen oder Solarzellen. Die Methode informiert auch über Isotopenverteilung und molekulare Zusammensetzung der Probe.
”The criterion was excellence“
Authors: Guggolz Ernst , Remenyi Christian 
Published: May 2010

AbstractThe 3rd Euchems Conference is an ideal platform for spotlighting chemistry as the key source of sustainable solutions to the mega‐topics and challenges facing all of us today: energy, food supplies, and resources in a healthy environment. Nachrichten aus der Chemie talked with Francois Diederich and Andreas Hirsch, chairs of the Scientific Committee.
Schnell zu Biarylen: Direkte Arylierung mit Arylhalogeniden
Authors: Kirsch Stefan , Harschneck Tobias 
Published: May 2010

AbstractKaum ein Feld der organischen Chemie ist in jüngerer Zeit so in Mode gekommen wie die C‐H‐Aktivierung. Insbesondere die direkte Arylierung mit Arylhalogeniden hat einen derart großen Reifegrad erreicht, dass sie zu einer echten Alternative zu klassischen Kreuzkupplungen mit Organometallverbindungen wird. Etliche Biarylverbindungen lassen sich bereits unter milden und experimentell einfachen Reaktionsbedingungen durch direkte Arylierung darstellen.
A family of ANS four‐node exact geometry shell elements in general convected curvilinear coordinates
Authors: Kulikov G. M. , Plotnikova S. V. 
Published: May 2010

AbstractThe non‐conventional exact geometry shell elements based on the Timoshenko–Mindlin kinematics with five displacement degrees of freedom are proposed. The term ‘exact geometry (EXG)’ reflects the fact that coefficients of the first and second fundamental forms of the reference surface and Christoffel symbols are taken exactly at every Gauss integration point. The choice of only displacements as fundamental shell unknowns gives an opportunity to derive strain–displacement relationships, which are invariant under rigid‐body shell motions in a convected curvilinear coordinate system. This paper presents a newly developed family consisting of three hybrid and one displacement‐based four‐node EXG shell elements. To avoid shear and membrane locking and have no spurious zero energy modes, the ANS concept is employed. The ANS interpolations satisfy exactly the plate compatibility equation for in‐plane strains. As a result, all EXG shell elements developed pass membrane and bending plate patch tests and exhibit a superior performance in the case of distorted coarse mesh configurations. Copyright © 2010 John Wiley & Sons, Ltd.
An extended finite element method applied to levitated droplet problems
Authors: Esser Patrick , Grande Jörg , Reusken Arnold 
Published: May 2010

AbstractWe consider a standard model for incompressible two‐phase flows in which a localized force at the interface describes the effect of surface tension. If a level set method is applied then the approximation of the interface is in general not aligned with the triangulation. This causes severe difficulties w.r.t. the discretization and often results in large spurious velocities. In this paper we reconsider a (modified) extended finite element method (XFEM), which in previous papers has been investigated for relatively simple two‐phase flow model problems, and apply it to a physically realistic levitated droplet problem. The results show that due to the extension of the standard FE space one obtains much better results in particular for large interface tension coefficients. Furthermore, a certain cut‐off technique results in better efficiency without sacrificing accuracy. Copyright © 2010 John Wiley & Sons, Ltd.
A parametric mapping method for curve shape optimization on 3D panel structures
Authors: Zhang Weihong , Wang Dan , Yang Jungang 
Published: May 2010

AbstractThree‐dimensional (3D) thin‐walled panels belong to a kind of lightweight structures that are widely used in aeronautic and aerospace engineering. This paper deals with the shape optimization of curved contours that exist often on this kind of structures. Compared with conventional 2D and 3D shape optimization problems, the particularity and difficulty existing here are how to define design variables properly so that the curve keeps moving on the specific surface of the curved panel during the design process. A new parametric mapping method (PMM) is therefore proposed in this paper. The originality is to manage shape design variables in the 2D intrinsic coordinate system. It is shown that the geometric limitation is satisfied automatically. Moreover, relevant formulations are developed theoretically for design sensitivity analysis. By means of the parametric mapping from 2D intrinsic coordinate system to Cartesian coordinate system, the mesh velocity field related to the finite element model can be easily computed for any unstructured mesh. Finally, a variety of representative examples are presented to illustrate the method. Copyright © 2010 John Wiley & Sons, Ltd.
Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance
Authors: Wermann Hendrik , Stoop Hans , Gillis Ad JM , Honecker Friedemann , van Gurp Ruud JHLM , Ammerpohl Ole , Richter Julia , Oosterhuis J Wolter , Bokemeyer Carsten , Looijenga Leendert HJ 
Published: May 2010

AbstractDifferences in the global methylation pattern, ie hyper‐ as well as hypo‐methylation, are observed in cancers including germ cell tumours (GCTs). Related to their precursor cells, GCT methylation status differs according to histology. We investigated the methylation pattern of normal fetal, infantile, and adult germ cells (n = 103) and GCTs (n = 251) by immunohistochemical staining for 5‐$^{\rm m}$cytidine. The global methylation pattern of male germ cells changes from hypomethylation to hypermethylation, whereas female germ cells remain unmethylated at all stages. Undifferentiated GCTs (seminomas, intratubular germ cell neoplasia unclassified, and gonadoblastomas) are hypomethylated, whereas more differentiated GCTs (teratomas, yolk sac tumours, and choriocarcinomas) show a higher degree of methylation. Embryonal carcinomas show an intermediate pattern. Resistance to cisplatin was assessed in the seminomatous cell line TCam‐2 before and after demethylation using 5‐azacytidine. Exposure to 5‐azacytidine resulted in decreased resistance to cisplatin. Furthermore, after demethylation, the stem cell markers NANOG and POU5F1 (OCT3/4), as well as the germ cell‐specific marker VASA, showed increased expression. Following treatment with 5‐azacytidine, TCam‐2 cells were analysed using a high‐throughput methylation screen for changes in the methylation sites of 14 000 genes. Among the genes revealing changes, interesting targets were identified: ie demethylation of KLF11, a putative tumour suppressor gene, and hypermethylation of CFLAR, a gene previously described in treatment resistance in GCTs. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Is there an association between bicuspid aortic valve and neuroblastoma?
Authors: Stefanski Heather , Wedel Lauren , Haller Courtney , Pierpont Mary Ella , Perkins Joanna L. 
Published: May 2010

AbstractAn association has been reported between neuroblastoma and congenital heart disease, frequently bicuspid aortic valve [Holzer and Franklin. Arch Dis Child 2002;87:61–64; George et al. J Pediatr 2004;144:444–448; Friedman et al. Pediatr Cardiol 1998;19:480–481; Monte et al. Am J Pediatr Hematol Oncol 1985;7:109–116]. To evaluate this in a large patient group with neuroblastoma, we examined echocardiograms of patients with neuroblastoma from 1987 to January 2007 to determine if there was a higher incidence of bicuspid aortic valves compared to the general population without neuroblastoma. We found that only 0.7% of neuroblastoma patients had the congenital heart defect of bicuspid aortic valves compared with 1–2% in the general population [Braverman et al. Curr Prob Cardiol 2005;30:470–522]. Our data show that neuroblastoma is not associated with bicuspid aortic valves. Pediatr Blood Cancer. 2010;55:359–360. © 2010 Wiley–Liss, Inc.
T‐cell acute lymphoblastic leukemia in association with Börjeson–Forssman–Lehmann syndrome due to a mutation in PHF6
Authors: Chao Mwe Mwe , Todd Matthew A. , Kontny Udo , Neas Katherine , Sullivan Michael J. , Hunter Alasdair G. , Picketts David J. , Kratz Christian P. 
Published: May 2010

AbstractBörjeson–Forssman–Lehmann syndrome (BFLS) is a rare X‐linked mental retardation syndrome that is caused by germline mutations in PHF6. We describe a 9‐year‐old male with BFLS, who developed T‐cell acute lymphoblastic leukemia (T‐ALL). The PHF6 gene is located on the X chromosome and encodes a protein with two PHD‐type zinc finger domains and four nuclear localization sequences. Previously, overexpression of Phf6 was observed in murine T‐cell lymphomas. Our observation indicates that BFLS may represent a cancer predisposition syndrome and that mutations of PHF6 contribute to T‐ALL. Pediatr Blood Cancer. 2010;55:722–724. © 2010 Wiley‐Liss, Inc.
Psychological support and care for young people with diabetes in the ‘transition’ period
Authors: Trigwell P , Jawad S 
Published: May 2010

AbstractThe aim of this survey was to determine the availability of psychological support and care for young people with diabetes in secondary care services in the Yorkshire and Humber NHS Region during the transition period (i.e. ages 16–25 years).The survey was developed in line with both National Institute for Health and Clinical Excellence (NICE) guidance and National Service Framework (NSF) standards specific to children and young people with diabetes. It was distributed to the diabetes services in all 20 centres within the Yorkshire and Humber NHS Region.The response rate for this survey was 100%. All centres were aware that children and young people with type 1 diabetes may develop anxiety and/or depression, and all (100%) or virtually all (95%) of the teams in the 20 centres agreed with the various key requirements stipulated in the relevant NICE guidance and NSF standards. However, many centres lacked key service elements, or indeed any plans to introduce them.The findings of this study are of national significance given the nature and size of the region studied and the likelihood that the national picture is similar to this. There is a general sense of awareness among diabetes services and teams regarding the need for psychological support and care for young people with diabetes in the transition period. Despite this, multiple gaps exist in services in relation to the already existing requirements and standards. The implications, including those for service commissioners, are discussed. Copyright © 2010 John Wiley & Sons.
British Association of Retinal Screeners (BARS): survey of workload in UK diabetic retinopathy screening programmes
Authors: Shotliff K , Duncan G , Dewhirst R , Dixon L , Ellingford A , Greenwood R , Mansell J , Mitchell P , Moss G 
Published: May 2010

AbstractThe aim of this survey was to determine the number of patients being screened per session in UK diabetic retinal screening programmes and the number of patients images being graded in stand alone grading sessions.A questionnaire was sent to all members of the British Association of Retinal Screeners asking for information about diabetic retinal screening schemes in which they were involved.Sixty‐eight (31%) replied and suggested that an average of 14.4 patients were being screened per session on a fixed site programme, and an average of 15.7 per session with a mobile service. A standard morning session was, on average, 3 hours and 23 minutes long on a fixed site and 3 hours and 14 minutes on a mobile site. A standard afternoon session was, on average, 3 hours and 5 minutes long on a fixed site and 2 hours and 44 minutes long on a mobile site. Those undertaking grading as a stand alone activity screened an average of 39.3 patients per session (ranging from 20–75 patients per session).While the lengths of morning and afternoon screening sessions were relatively consistent there was more variability in the number of patients whom a stand alone grader would typically grade per session. We believe this range of activity reinforces the importance of a good quality assurance programme to maintain the consistency of the service offered. Copyright © 2010 John Wiley & Sons.
Global analysis of the rat and human platelet proteome – the molecular blueprint for illustrating multi‐functional platelets and cross‐species function evolution
Authors: Yu Yanbao , Leng Taohua , Yun Dong , Liu Na , Yao Jun , Dai Ying , Yang Pengyuan , Chen Xian 
Published: May 2010

AbstractEmerging evidences indicate that blood platelets function in multiple biological processes including immune response, bone metastasis and liver regeneration in addition to their known roles in hemostasis and thrombosis. Global elucidation of platelet proteome will provide the molecular base of these platelet functions. Here, we set up a high‐throughput platform for maximum exploration of the rat/human platelet proteome using integrated proteomic technologies, and then applied to identify the largest number of the proteins expressed in both rat and human platelets. After stringent statistical filtration, a total of 837 unique proteins matched with at least two unique peptides were precisely identified, making it the first comprehensive protein database so far for rat platelets. Meanwhile, quantitative analyses of the thrombin‐stimulated platelets offered great insights into the biological functions of platelet proteins and therefore confirmed our global profiling data. A comparative proteomic analysis between rat and human platelets was also conducted, which revealed not only a significant similarity, but also an across‐species evolutionary link that the orthologous proteins representing “core proteome”, and the “evolutionary proteome” is actually a relatively static proteome.
Fatigue in prostate cancer survivors treated with definitive radiotherapy and LHRH analogs
Authors: Kyrdalen Anne E. , Dahl Alv A. , Hernes Eivor , Hem Einar , Fosså Sophie D. 
Published: May 2010

AbstractBACKGROUNDFew studies have dealt with chronic fatigue (CF) in definitive radiotherapy (RAD) patients during and after (neo‐)adjuvant androgen deprivation therapy (ADT) for prostate cancer.METHODSCF was the primary outcome in this population‐based cross‐sectional study as evaluated by the Fatigue Questionnaire. We compared the post‐RAD levels of fatigue in two groups of ≥1 year prostate cancer survivors; those with ongoing medical castration (HTcont) and those who had used a luteinizing hormone‐releasing hormone analog (LHRHa), but had discontinued the therapy at the time of the survey (HTdis). The prevalence of CF and the levels of total fatigue were compared to comparable parameters in men with prostatic RAD who never had had ADT (Control group) and to men >60 years old from the general population.RESULTSAfter an observation time of median 18 months since start of radiotherapy about 40% of our ≥1 year prostate cancer survivors from the HTcont group reported CF, as compared to approximately a quarter of men from the HTdis group and, the prevalence of CF in the latter group being similar to that of hormone‐naïve RAD controls and males from the general population. After discontinuation of ADT, age 65 years or below was associated with increased risk of CF.CONCLUSIONSPre‐counseling of prostate cancer patients starting (neo‐)adjuvant LHRHa therapy must include fatigue, mainly physical fatigue, in particular in men aged 65 years or younger. Future studies of testosterone recovery after ADT discontinuation should also include measures of CF. Prostate 70: 1480–1489, 2010. © 2010 Wiley‐Liss, Inc.
Plateau stress of paper honeycomb as response to various relative humidities
Authors: E Yu‐Ping , Wang Zhi‐Wei 
Published: May 2010

AbstractA mathematical model was developed to predict the plateau stress of axially loaded paper honeycombs in various humidity environments. It is a simple formula relating the plateau stress to the thickness‐to‐length ratio of a honeycomb cell, the yielding stress of a cell‐wall material tested under a controlled atmosphere [23°C and 50% relative humidity (RH)] and the ambient RH. Paper honeycombs with various thickness‐to‐length ratios were researched under several levels of RH, and the plateau stress of each kind of paper honeycomb was obtained. The created model was then verified by comparing the predictions with observations. A good agreement between them corroborates the feasibility and accuracy of the model. Predictions by the present model and those by empirical relations were compared as well. A better prediction was obtained using the present model for a wide range of thickness‐to‐length ratios, suggesting that the present model can replace empirical formulas to provide more accurate and effective predictions of the plateau stress for paper honeycombs. The proposed method can be used to characterize the energy‐absorption properties of paper honeycombs in an actual logistic environment, and so can be used to optimize the structural design of paper honeycombs. Copyright © 2010 John Wiley & Sons, Ltd.
An evaluation of the ability of RFID tags to withstand distribution of fresh produce in the RPC pooling system
Authors: Singh J. , Singh S. P. , Desautels K. , Saha K. , Olsen E. 
Published: May 2010

AbstractThis study focused on the ability of radio frequency identification (RFID) tags applied on reusable plastic containers (RPCs) to withstand repeated abuse due to physical distribution and storage environment related hazards. It also studied the effect of the chemical cleaning environments that RPCs are commonly exposed to in the pooling/rental systems commonly used to distribute fresh produce. RPCs are being successfully deployed in the US, Europe and Asia to ship fresh produce from growers to retailers. The increasing demand for traceability and tracking of fresh produce from ‘farm to fork’ requires these containers to be monitored and identified in the food supply chain, and RFID technology provides one of the solutions. This study compared eight commercially available RFID tags mounted on RPCs for use in fresh produce distribution and subjected them to repeated physical and climatic cycles representing the distribution and cleaning environments, and their effective ‘read’ capabilities were tested. Copyright © 2010 John Wiley & Sons, Ltd.