bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relational and social‐cognitive correlates of early adolescents’ forgiveness of parents
Authors: Christensen Katherine J. , Padilla‐Walker Laura M. , Busby Dean M. , Hardy Sam A. , Day Randal D. 
Published: February 2011

ABSTRACTThis study examined how mother and father–child relationship quality and marital forgiveness were related to early adolescents’ forgiveness of mothers and fathers. Adolescents’ social‐cognitive skills (empathy and emotional regulation) and parents’ forgiveness of child were examined as mediators. Mother, father, and child self‐reported questionnaires and observational data were taken from Time 1 and Time 3 (two years later) of the Flourishing Families Project, and included 334 two‐parent families with an early adolescent (M age at Time 1 = 11.24; 51% male; 76% Caucasian). Using path analyses via structure equation modeling, mother–child relationship quality and adolescents’ own social‐cognitive skills were salient correlates of adolescents’ forgiveness toward parents. The unique contributions of mothers and fathers, differences by reporter, and the importance of studying forgiveness within the parent–child relationship are discussed.
Psychometric properties of the Spanish version of the Diagnostic Interview for Depressive Personality
Authors: Irastorza L.J. , Rojano P. , Gonzalez-Salvador T. , Cotobal J. , Leira M. , Rojas C. , Rubio G. , Rodríguez-Rieiro C. , Bellon J.M. , Alvarez M. , Rodríguez C. , Arango C. 
Published: February 2011

AbstractThe aim of this study was to evaluate the reliability and validity of the Spanish-language version of the Diagnostic Interview for Depressive Personality (DIDP). The DIDP was administered to 328 consecutive outpatients and the test–retest and inter-rater reliability were assessed. Factor analysis was used in search of factors capable of explaining the scale and a cutoff point was established. The DIDP scales showed adequate Cronbach'sαvalues and acceptable test–retest and inter-rater reliability coefficients. Convergent and discriminant validity were explored, the latter with respect to avoidant and borderline personality disorders. The results of the factor analysis were consistent with the four-factor structure of the DIDP scales. The receiver operating characteristic (ROC) analysis revealed the area under the curve to be 0.848. We found 30 to be a good cutoff point, with a sensitivity of 74.5% and a specificity of 78.5%. The DIDP proved to be a reliable and valid instrument for assessing depressive personality disorder, at least among our outpatients. The psychometric properties of the DIDP support its clinical usefulness in assessing depressive personality.
Perceived negative attitude of others predicts transition to psychosis in patients at risk of psychosis
Authors: Salokangas R.K.R. , Patterson P. , Heinimaa M. , Svirskis T. , From T. , Vaskelainen L. , Klosterkötter J. , Ruhrmann S. , von Reventlow H.G. , Juckel G. , Linszen D. , Dingemans P. , Birchwood M. ,   the EPOS Group
Published: February 2011

AbstractAimOur previous study (Salokangas et al., 2009) suggested that the subjective experience of negative attitude of others (NAO) towards oneself is an early indicator of psychotic development. The aim of this prospective follow-up study was to test this hypothesis.MethodsA total of 55 young psychiatric outpatients assessed as being at current risk of psychosis (CROP) were followed for up to 60 months and rates of transition to psychosis (TTP) identified. CROP was assessed employing the Bonn Scale for assessment of basic symptoms (Schultze-Lutter and Klosterkötter, 2002) and the Structured Interview for prodromal symptoms (Miller et al., 2002). TTP was defined by a psychotic episode lasting for more than one week. Associations between NAO at baseline and TTP were analyzed by a Cox regression survival analysis.ResultsEight (14.5%) TTP were identified: four (57.1%) within seven NAO patients and four (8.7%) within forty-six non-NAO patients. In the multivariate Cox regression analysis, NAO at baseline significantly (P = 0.007) predicted TTP.ConclusionThe prospective follow-up results support our hypothesis that subjective experience of NAO is an early indicator of psychotic in development.
Use of psychiatric inpatient services by heavy users: Findings from a national survey in Italy
Authors: Morlino M. , Calento A. , Schiavone V. , Santone G. , Picardi A. , de Girolamo G. ,   for the PROGRES-Acute group
Published: February 2011

AbstractPurposeTo analyze factors associated with a patient's probability of being a Heavy User (HU) of inpatient psychiatric services and to compare the HU inpatient population with Non-Heavy Users (NHUs).Patients and methodsThe survey was conducted among inpatients enrolled in the PROGRES-Acute-project, an Italian nationwide survey of public and private inpatient facilities. Patients with three or more admissions over the last 12 months were considered HUs, and patients who had undergone one or two admissions during the same period made up the NHU group.ResultsFour hundred and thirty-five (40.5%) were HUs, and 640 (59.5%) NHUs. HUs were younger, more frequently unmarried, unemployed, receiving a disability-pension, and either homeless or living in a residential facility. HUs were more likely to have experienced conflicts with their partners or family members during the week prior to admission. A logistic regression analysis revealed that age, age at first admission, number of life-time admissions, and having been the victim of violence were the most important predictive factors for the HU phenomenon.ConclusionOur study suggests that specific attention should be given to patients’ family context, due to its crucial role in daily informal care and in the triggering of events leading to rehospitalization.
Variation in use of coercive measures in psychiatric hospitals
Authors: Lay B. , Nordt C. , Rössler W. 
Published: February 2011

AbstractPurposeThe use of coercive measures in psychiatry is still poorly understood. Most empirical research has been limited to compulsory admission and to risk factors on an individual patient level. This study addresses three coercive measures and the role of predictive factors at both patient and institutional levels.MethodsUsing the central psychiatric register that covers all psychiatric hospitals in Canton Zurich (1.3 million people), Switzerland, we traced all inpatients in 2007 aged 18–70 (n = 9698). We used GEE models to analyse variation in rates between psychiatric hospitals.ResultsOverall, we found quotas of 24.8% involuntary admissions, 6.4% seclusion/restraint and 4.2% coerced medication. Results suggest that the kind and severity of mental illness are the most important risk factors for being subjected to any form of coercion. Variation across the six psychiatric hospitals was high, even after accounting for risk factors on the patient level suggesting that centre effects are an important source of variability. However, effects of the hospital characteristics ‘size of the hospital’, ‘length of inpatient stay’, and ‘work load of the nursing staff’ were only weak (‘bed occupancy rate’ was not statistically significant).ConclusionThe significant variation in use of coercive measures across psychiatric hospitals needs further study.
Prognostic value of TNM stage and tumor necrosis for renal cell carcinoma
Authors: Chang Ying‐Hsu , Chuang Cheng‐Keng , Pang See‐Tong , Wu Chun‐Te , Chuang Kun‐Lung , Chuang Heng‐Chang , Liao Shuen‐Kuei 
Published: February 2011

AbstractOur objective was to assess the value of tumor necrosis and other factors for predicting the outcome of renal cell carcinoma (RCC). Our study comprised 328 RCC patients who were surgically treated at this hospital between 2001 and 2006. The five‐year survival data was analyzed using a Kaplan‐Meier statistical analysis. The prognostic factors were evaluated with a univariate analysis using a log‐rank test and multivariate analysis using the Cox proportional hazards regression method. The mean follow‐up period for these patients was 46.5 months (median 45.2 months). The univariate analysis revealed that age, tumor stage, TNM stage, grade, tumor necrosis, and histological type were statistically significant prognostic factors. The multivariate analysis showed that the TNM stage and tumor necrosis were the most important predictive factors in the patients' overall survival. In the TNM stage with and without tumor necrosis, the five‐year overall survival rates in stages I + II were 80.5% and 89.2%, respectively (p = 0.115), where as the five‐year survival rates in stages III + IV were 32.7% and 84.0%, respectively (p < 0.001). Collectively, our present data revealed that tumor necrosis was an important predictive factor for survival in advanced stage RCC. In conclusion, both the TNM stage and tumor necrosis provided the most important prognostic factors of survival in RCC. Tumor necrosis proved to be a poor prognostic factor in advanced RCCs.
Vetting the Advocacy Agenda: Network Centrality and the Paradox of Weapons Norms
Authors: Carpenter R. Charli 
Published: February 2011

AbstractWhile a number of significant campaigns since the early 1990s have resulted in bans of particular weapons, at least as many equivalent systems have gone unscrutinized and uncondemned by transnational campaigners. How can this variation be explained? Focusing on the issue area of arms control advocacy, this article argues that an important influence on the advocacy agenda within transnational networks is the decision-making process not of norm entrepreneurs nor of states but of highly connected organizations within a given network. The argument is illustrated through a comparison between existing norms against landmines and blinding laser weapons, and the absence of serious current consideration of such norms against depleted uranium and autonomous weapons. Thus, the process of organizational issue selection within nongovernmental organizations (NGOs) and international organizations (IOs) most central to particular advocacy networks, rather than the existence of transnational networks around an issue per se, should be a closer focus of attention for scholars interested in norm creation in world politics.
Increased blastocyst formation of cloned porcine embryos produced with donor cells pre-treated with Xenopus egg extract and/or digitonin
Authors: Liu Ying , Østrup Olga , Li Juan , Vajta Gábor , Lin Lin , Kragh Peter M. , Purup Stig , Hyttel Poul , Callesen Henrik 
Published: February 2011

SummaryPre-treating donor cells before somatic cell nuclear transfer (SCNT, ‘cloning’) may improve the efficiency of the technology. The aim of this study was to evaluate the early development of cloned embryos produced with porcine fibroblasts pre-treated with a permeabilizing agent and extract from Xenopus laevis eggs. In Experiment 1, fetal fibroblasts were permeabilized by digitonin, incubated in egg extract and, after re-sealing of cell membranes, cultured for 3 or 5 days before use as donor cells in handmade cloning (HMC). Controls were produced by HMC with non-treated donor cells. The blastocyst rate for reconstructed embryos increased significantly when digitonin-permeabilized, extract-treated cells were used after 5 days of culture after re-sealing. In Experiment 2, fetal and adult fibroblasts were treated with digitonin alone before re-sealing the cell membranes, then cultured for 3 or 5 days and used as donor cells in HMC. Treatment with digitonin alone increased the blastocyst rate, but only when fetal, and not adult fibroblasts, were used as donor cells, and only after 3 days of culture. In conclusion, we find a time window for increased efficiency of porcine SCNT using donor cells after pre-treatment with permeabilization/re-sealing and Xenopus egg extract. Interestingly, we observe a similar increase in cloning efficiency by permeabilization/re-sealing of donor cells without extract treatment that seems to depend on choice of donor cell type. Thus, pre-treatment of donor cells using permeabilizing treatment followed by re-sealing and in vitro culture for few days could be a simple way to improve the efficiency of porcine cloning.
Post-thaw culture in presence of insulin-like growth factor I improves the quality of cattle cryopreserved embryos
Authors: Makarevich Alexander V. , Kubovičová Elena , Hegedušová Zdena , Pivko Juraj , Louda František 
Published: February 2011

SummaryThe goal of this study was to examine the effect of insulin-like growth factor I (IGF-I; added during post-thaw culture (48 h)) on the preimplantation viability and quality of cryopreserved bovine in vivo recovered embryos. The morula stage embryos, non-surgically recovered from superovulated dairy cows of Czech Fleckvieh cattle breed, had previously been cryopreserved by a slow freezing technique and stored in liquid nitrogen since 1989–1990. Following thawing, the embryos were cultured for 48 h either alone (no IGF-I) or in the presence of IGF-I (10 or 100 ng/ml); non-cultured embryos served as a control. Thereafter, the embryos were analyzed for cleavage to the blastocyst stage, apoptosis (TUNEL), embryo cell number and quality of actin cytoskeleton. Following post-thaw culture 41% of embryos developed to advanced blastocysts. IGF-I increased this per cent and, at a higher dose, essentially reduced the per cent of degenerated embryos. In cultured embryos, IGF-I at both doses elevated the cell number compared with non-cultured embryos. However, in comparison with embryos cultured without IGF-I, only the higher IGF-I dose resulted in elevating the embryo cell number. The TUNEL index was significantly lowered by IGF-I treatment. Thawed embryos were mostly of the grade III actin type and fewer (12%) had grade II actin, whilst no grade I actin embryos were noted. The addition of IGF-I resulted in the appearance of grade I actin embryos (8.33 and 6.9% for 10 and 100 ng/ml, respectively). These observations indicate that the addition of IGF-I during post-thaw culture can improve the quality of bovine cryopreserved embryos.
Linking reduced deforestation and a global carbon market: implications for clean energy technology and policy flexibility
Authors: BOSETTI VALENTINA , LUBOWSKI RUBEN , GOLUB ALEXANDER , MARKANDYA ANIL 
Published: February 2011

ABSTRACTThis study uses a global climate-energy-economy model to investigate potential implications of linking credits from reducing emissions from deforestation and forest degradation in developing countries to a global carbon market, focusing on reducing emissions from deforestation (RED) and effects on energy technology innovation. Integrating RED into a global carbon market lowers the estimated total costs of a policy to achieve 535 ppmv of CO2-equivalent concentrations in 2100 by up to 25 per cent. Alternatively, a global RED program could enable additional reductions of about 20 ppmv by 2100 with no added costs compared with an energy-sector-only policy. The results indicate that market linkage of RED induces modest reductions in clean energy innovation overall but slightly enhances development of particular technologies, including carbon capture and storage. We also find that RED in combination with credit banking encourages greater mitigation in the near term, enhancing flexibility to potentially tighten emission targets at lower cost in response to future information.
Structural dependence of HET-s amyloid fibril infectivity assessed by cryoelectron microscopy
Authors: Mizuno Naoko , Baxa Ulrich , Steven Alasdair C. 
Published: February 2011

HET-s is a prion protein of the fungus
Podospora anserina
which, in the prion state, is active in a self/nonself recognition process called heterokaryon incompatibility. Its prionogenic properties reside in the C-terminal “prion domain.” The HET-s prion domain polymerizes in vitro into amyloid fibrils whose properties depend on the pH of assembly; above pH 3, infectious singlet fibrils are produced, and below pH 3, noninfectious triplet fibrils. To investigate the correlation between structure and infectivity, we performed cryo-EM analyses. Singlet fibrils have a helical pitch of approximately 410 Å and a left-handed twist. Triplet fibrils have three protofibrils whose lateral dimensions (36 × 25
Å
) and axial packing (one subunit per 9.4 Å) match those of singlets but differ in their supercoiling. At 8.5-Å resolution, the cross-section of the singlet fibril reconstruction is largely consistent with that of a β-solenoid model previously determined by solid-state NMR. Reconstructions of the triplet fibrils show three protofibrils coiling around a common axis and packed less tightly at pH 3 than at pH 2, eventually peeling off. Taken together with the earlier observation that fragmentation of triplet fibrils by sonication does not increase infectivity, these observations suggest a novel mechanism for self-propagation, whereby daughter fibrils nucleate on the lateral surface of singlet fibrils. In triplets, this surface is occluded, blocking nucleation and thereby explaining their lack of infectivity.
SpaCEM3: a software for biological module detection when data is incomplete, high dimensional and dependent
Authors: Vignes Matthieu , Blanchet Juliette , Leroux Damien , Forbes Florence 
Published: February 2011

Abstract
Summary: Among classical methods for module detection, SpaCEM3 provides ad hoc algorithms that were shown to be particularly well adapted to specific features of biological data: high-dimensionality, interactions between components (genes) and integrated treatment of missingness in observations. The software, currently in its version 2.0, is developed in C++ and can be used either via command line or with the GUI under Linux and Windows environments.
Availability: The SpaCEM3 software, a documentation and datasets are available from http://spacem3.gforge.inria.fr/.
Contact: matthieu.vignes@toulouse.inra.fr; SpaCEM3-help@lists.gforge.inria.fr
Synergistic effects of elevated CO2 and temperature on the metabolic scope and activity in a shallow-water coastal decapod (Metapenaeus joyneri; Crustacea: Penaeidae)
Authors: Dissanayake Awantha , Ishimatsu Atsushi 
Published: February 2011

AbstractDissanayake, A., and Ishimatsu, A. 2011. Synergistic effects of elevated CO2 and temperature on the metabolic scope and activity in a shallow-water coastal decapod (Metapenaeus joyneri; Crustacea: Penaeidae). – ICES Journal of Marine Science, 68: 1147–1154. The physical drivers of climate change (increased CO2; hypercapnia and temperature) are causing increasing warming of the earth's oceans, elevating oceanic CO2 concentrations, and acidity. Elucidating possible climate change impacts on marine biota is of paramount importance, because generally, invertebrates are more sensitive to hypercapnia than fish. This study addresses impacts of synergistic factors; hypercapnia and temperature on osmoregulation, acid–base balance, and resting and active metabolism (assessed as oxygen consumption rates) and behavioural performance in a model nektonic crustacean. Metapenaeus joyneri exposed to both hypercapnia (1 kPa) at two temperatures (15 and 20°C) demonstrated significant physiological effects, i.e. new regulatory set points (lower haemolymph osmolality and higher pH, i.e. alkalosis) and reduced metabolic scope (MS), compared with control individuals (normocapnia, 0.04 kPa). Behavioural effects included a significant 30% reduction in swimming ability and may be the result of reduced MS (i.e. difference between active and routine metabolism). Synergistic factors may cause organisms to shift energy utilization towards up-regulation of maintenance functions (i.e. osmoregulatory ability) resulting in a decrease in both aerobic scope and energy-demanding activities. Laboratory-derived evidence elucidating the impacts in key model groups is of paramount importance, if we are to improve our knowledge of physiological effects of synergistic climate change factors.
Distribution of Total, Water‐Unextractable, and Water‐Extractable Arabinoxylans in Wheat Flour Mill Streams
Authors: Ramseyer Daniel D. , Bettge Arthur D. , Morris Craig F. 
Published: February 2011

ABSTRCTArabinoxylans are a minor but important constituent in wheat that affects bread quality, foam stability, batter viscosity, and sugar snap cookie diameter. Therefore, it is important to determine the distribution of arabinoxylans in flour mill streams to better formulate flour blends. Thirty‐one genetically pure grain lots representing six wheat classifications common to the western U.S. were milled on a Miag Multomat pilot mill, and 10 flour mill streams were collected from each. A two‐way ANOVA indicated that mill streams were a greater source of variation compared to grain lots for total arabinoxylans (TAX), water‐unextractable arabinoxylans (WUAX), and water‐extractable arabinoxylans (WEAX). TAX and WUAX were highly correlated with ash at r = 0.94 and r = 0.94, respectively; while the correlation for WEAX and ash decreased in magnitude at r = 0.60. However, the 5th middlings mill streams exhibited disparity between TAX and ash content as well as between WUAX and ash content. This may indicate that TAX and WUAX in mill streams are not always the result of bran contamination. Cumulative extraction curves for TAX, WUAX and WEAX revealed increasing gradients of arabinoxylans parallel to extraction rate. Therefore, arabinoxylans may be an indicator of flour refinement.
Quality of Fats in Cookies as Affected by Storage and Addition of Oat Flakes
Authors: Zbikowska Anna , Rutkowska Jarosława 
Published: February 2011

ABSTRACTChanges in fats extracted from cookies stored for three or five weeks and containing different levels of oat flakes (10, 20, 30%) were investigated. The fats used for baking differed in fatty acid (FA) composition and contained 17.6–57.6% saturated (SFA), 0.8–46.8% trans FA (TFA), and 0.6–6.6% polyunsaturated FA (PUFA). Oat flakes were steam stabilized and were in the middle of their shelf‐life. Oat flakes contained 9.5% lipids in which linoleic acid (C 18:2 9c 12c) predominated, amounting to 42.7%. Increasing the content of oat flakes and the storage time of cookies resulted in increased values of primary and secondary fat oxidation products. Highest increases in PV values were found in cookies stored for three or five weeks, especially with a high content of oat flakes (30%). Secondary lipid oxidation products measured by AnV values increased with the time of storage. Highest increases in hydrolytic and oxidation products were associated with higher content (6.6%) of PUFA in utilized fats. Regarding the degree of oxidation, it appears safe to add as much as 30% of oat flakes to cookies when the storage time does not exceed three weeks.