bluuebunny/crossref_metadata_2025_split huggingface dataset:
A logic of higher-order preferences
Authors: Jiang Junli , Naumov Pavel 
Published: June 2024

AbstractIf an agent prefers one kind of agents to the other agents, then the agent has first-order preferences. If the agent prefers agents with one kind of preferences to the other agents, then the agent has second-order preferences. The article proposes a sound, complete, and decidable logical system capable of expressing higher-order preferences.
Don’t imagine junk! Positive conceivability and modal illusion in mereology
Authors: Dohrn Daniel 
Published: June 2024

AbstractThere is a widespread practice of using evidence obtained from conceiving/imagining for establishing possibility claims. As a case study. I offer a critical reconstruction of an influential conceivability argument, Bohn’s (Philosophical Quarterly 59:193-201, 2009a, Analysis 70:296–298, 2009b, Analysis 70:296-298, 2010) argument for junk (there are proper parts forming wholes, but there is no whole that is not a proper part itself). The most influential scenario used by Bohn and his successors is purported to be junk but not ensured to be junk. This finding calls for an explanation. I distinguish ways of conceiving/imagining that are insufficient to establish modal claims from positive conceiving/imagining, which is more promising. Positive conceiving/imagining often works by a partial structural isomorphy to its target, and it is sufficiently detailed. In order to be sufficiently detailed, it has to properly integrate theoretical considerations. I outline a concern about extant ways of conceiving/imagining junk: they do not yet include a metaphysical understanding of what it takes for there to be proper parts and wholes without a whole that is not a proper part itself, for instance in terms of a non-gerrymandered principle of composition.
Comparison of proximal and distal laparoscopic ureteroureterostomy for complete duplex kidneys in children
Authors: Zhu Xiao-Jiang , Huang Li-Qu , Liu Saisai , Dong Jun , Zhu Hao-Bo , Chen Chen-Jun , Wang Li-Xia , Guo Yun-Fei , Deng Yong-Ji , Lu Ru-Gang 
Published: June 2024

Abstract
Objective
To compare efficacy of proximal and distal laparoscopic ureteroureterostomy (UU) for complete duplex kidneys in children.

Methods
Patients who underwent laparoscopic UU for complete duplex kidneys between December 2016 and July 2022 were reviewed retrospectively. 71 patients who had normal lower pole moiety without vesicoureteral reflux (VUR) were recruited. All of them underwent ultrasound, voiding cystourethrography (VCUG), renal scintigraphy, and magnetic resonance urography preoperatively. Proximal laparoscopic UU was performed in 35 patients and distal laparoscopic UU in 36 patients. Double J stents were placed in normal lower pole moieties. Clinical data, including general information, diagnosis, surgical management, imaging characteristics, clinical symptoms and postoperative complications (classified according to the modified Clavien–Dindo classification), and length of stay were recorded. Measurement date comparisons between groups were performed by t test, counting date were analyzed by chi-square test.

Results
The study consisted of 71 patients (56 females and 15 males) with complete duplex kidneys (41 in left kidney and 30 in right kidney). The patients’ mean age was 34 m (range 3–161 m) and follow-up ranged from 25 to 81 m. No significant difference was found in age and follow-up time between the two groups. Laparoscopic UU was performed in all patients successfully. The operation time of the two groups was 108.42 ± 26.95 min for distal UU vs 121.46 ± 35.15 min for proximal UU(p = 0.14). No significant difference in postoperative complications was seen between the two groups (22.2% vs 31.4%, p = 0.345). However, in terms of the grading of postoperative complications, the proximal UU group had a higher grade (3 of them had a grade of IV) and more serious complications.

Conclusions
There was no significant difference in the overall incidence of complications between distal and proximal UU. Compared with proximal laparoscopic UU, distal laparoscopic UU is easier to perform with less injury to the peripheral tissues. Postoperative complications of proximal UU are more serious and more difficult to manage. We recommend complete duplex kidney ureteral reconstruction with distal UU.
SNP genotyping Dutch heritage apple cultivars allows for germplasm characterization, curation, and pedigree reconstruction using genotypic data from multiple collection sites across the world
Authors: Larsen Bjarne , van Dooijeweert Willem , Durel Charles-Eric , Denancé Caroline , Rutten Marcel , Howard Nicholas P. 
Published: June 2024

AbstractThe curation and preservation of Dutch apple germplasm depends on reliable accession level information. However, many accessions of Dutch heirloom apple cultivars maintained publicly by the “Centre for Genetic Resources, the Netherlands” (CGN) and privately by Dutch pomological societies lack information regarding true-to-typeness and pedigree ancestry. The aim of this study was to address this knowledge gap by genotyping 652 apple accessions maintained in the CGN collection and Dutch private collections, compare their genotypic information to each other and to a large database of apple cultivars from around the world to identify genotypic duplicates and pedigree relationships for the Dutch apple cultivars. Towards this aim, accessions were genotyped on the 20 K Illumina Infinium(R) apple SNP array and with 15 SSR markers. Each accession was assigned to a genotypic profile code (MUNQ codes, as used in previous studies) facilitating communication regarding genotypic duplicates. There were 211 (51.1%) genotypic profiles in the Dutch germplasm which were not identified in other germplasm collections. Private collections maintained many of these unique accessions, including important pedigree ancestors. The study identified a number of common pedigree ancestors of Dutch cultivars, such as ‘Herfst Bloem Soete’, ‘Huismanszoet’ (2), and ‘Reinette Rouge Étoilée’. The duplicate and pedigree reconstruction results and relevant literature descriptions were used to pomologically verify the identity of relevant accessions. The results of this study resolved identity disputes, helped to decide which accessions should be retained or included in the CGN collection, and benefited ongoing pomological studies in ancestry and provenance of traditional Dutch cultivars.
Influence of grain concentrations gradients on the profiling behaviour of bronze bonded diamond grinding wheels
Authors: Denkena Berend , Bergmann Benjamin , Raffalt Daniel , Tontsch Maximilian 
Published: June 2024

AbstractIn this work, diamond grinding wheels are first manufactured with two different metallic bonds. These are a ductile and a brittle bronze. Two differently graded (varied grain concentration) grinding wheels and two non-graded reference grinding wheels are manufactured in each case. The mechanical properties of these are then determined. Subsequently, a method is presented that enables the profiling of graded grinding wheels. For this purpose, the grinding wheels are profiled with SiC rolls using different profiling parameters. The profile accuracy after profiling is analysed using contour profiles in polyurethane. In addition, the dressing ratio and the process duration of profiling are measured. These parameters are used to determine the economic efficiency of the profiling process. Finally, this provides a bond-dependent profiling process that can economically and reproducibly generate a target contour on a grinding tool.
Analysis of gastric electrical rhythm in patients with type 2 diabetes mellitus
Authors: Wang Xixi , Ma Lianhua , Jiang Miao , Zhu Hong , Ni Chendong , Yang Xiaohua , Hu Ji , Zhang Hong-Hong 
Published: June 2024

Abstract
Aim
To analysis the change of electrogastrogram (EGG) in patients with type 2 diabetes mellitus (T2DM), and evaluate the prevalence of abnormal gastric electrical rhythm (AGER) and its relative influencing factors.

Methods
A total of 65 patients with T2DM hospitalized at the Second Affiliated Hospital of Soochow University from Dec. 2020 to Dec. 2021 were included in the cross-sectional study. General information, clinical data, and medical history data of all study subjects, including name, gender, body mass index (BMI), duration of diabetes, anti-diabetic therapies, high blood pressure (HBP) history, smoking history, and medication history, were completely collected. The results of laboratory tests, including biochemical parameters, glycosylated hemoglobin (HbA1c), fasting C-peptide, 2 h postprandial C-peptide, 24 h urine total protein (24 hUTP), urine microalbumin creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR) were recorded. EGG, Gastroparesis Cardinal Symptom Index (GCSI), gastric emptying ultrasound, fundus examination, carotid artery ultrasonography, cardiac autonomic function test, heart rate variability (HRV) were all examined and recorded as well. According to the results of EGG, the subjects were divided into normal gastric electrical rhythm (NGER) group and abnormal gastric electrical rhythm (AGER) group.

Results
(1) Fasting blood glucose (FBG), HbA1c, the presence of diabetic peripheral neuropathy (DPN) and diabetic cardiac autonomic neuropathy (DCAN) were significantly higher in the AGER group (p < 0.05). Low frequency (LF) and high frequency (HF), the indicators of HRV, were significantly lower in the AGER group (p < 0.05). In addition, the prevalence of feeling excessively full after meals, loss of appetite, and stomach or belly visibly larger after meals of gastrointestinal symptoms of gastroparesis were significantly higher in the AGER group (p < 0.05). Multiple logistic regression analysis showed that FBG and the prevalence of DCAN were the independent risk factors.

Conclusion
AGER was associated with high FBG and the presence of DCAN. EGG examination is recommended for patients with gastrointestinal symptoms and clues of DCAN.
Acute promyelocytic leukemia in children cancer hospital Egypt
Authors: Semary Samah , Hammad Mahmoud , Yassin Dina , El Sharkawy Nahla , Soliman Sonya , Salem Sherine , Ezzat Emad , Mosa Ahmed , Ahmed Sonia 
Published: June 2024

Abstract
Background
Pediatric acute promyelocytic leukemia (APL) accounts for 5 to 15% of all myelocytic leukemia. A retrospective analysis of pediatric patients diagnosed and treated with APL was conducted at CCHE from July 2012 to the end of December 2019, to report the prevalence, clinical characteristics, results, and risk factors associated with induction failure and early death.

Result
Sixty-two patients were reported, with an age greater than ten, an initial poor coagulation profile, and a total leukocyte count (TLC) greater than 30 103/mm3 influencing 5-year overall (OS) and event-free survival (EFS), as well as a high promyelocyte count affecting 5-year EFS. Patients received a regimen based on the COG AAML0631 protocol. High-risk patients with an initial TLC > 10 × 103/mm3 and an initial promyelocytic count of 30% or more with a substantial P-value are prognostic markers for early death during induction. In females, wild FLT3 increases the risk of differentiation syndrome (DS). Receiving steroids with all-trans retinoic acid (ATRA) induction may reduce the occurrence of DS. Relapse alters the outcome. In the current study, 45 patients are alive in complete remission, with a 5-year OS of 72.5% and a 5-year EFS of 69.4%, respectively.

Conclusion
Pediatric APL outcomes are influenced by age above 10, an initial poor coagulation profile, and a promyelocyte count of more than 10%. An initial leukocyte count of more than 10 × 103/mm and an initial promyelocytic count of more than 30% increase the risk of early death. Receiving steroids with ATRA may reduce the occurrence of DS.
Insights into the prognostic value and immunological role of CD74 in pan-cancer
Authors: Liu Zebiao , Chen Mingquan , Zheng Wanhua , Yuan Shicheng , Zhao Wenli 
Published: June 2024

Abstract
Background
CD74 is a non-polymorphic type II transmembrane glycoprotein. It is involved in the regulation of T and B cell development, and dendritic cell (DC) motility. Numerous studies have found that CD74 exerts an essential role in tumor immunity, but the expression profile of CD74 is still not systematically reported, and its value in human pan-cancer analysis is unknown. In this study, we analyzed the expression pattern of CD74 in 33 cancers, and evaluated the significance of CD74 in prognosis prediction and cancer immunity.

Methods
Pan-cancer dataset from UCSC Xena.We used the Sangerbox website combined with R software’ Timer, CIBERSORT method and IOBR package to analyze and plot the data. Survival was assessed using the Kaplan—Meier method and log—rank test for 33 cancer types (p < 0.05). In addition, to explore the relationship between CD74 expression and immune checkpoints, immune cell infiltration, tumor mutational burden (TMB) and microsatellite instability (MSI), Spearman correlation analysis was performed.

Results
This study comprehensively analyzed CD74 expression in 33 different tumor types, revealing that CD74 play an crucial role in cancer formation and development.

Conclusions
CD74 gene expression in different cancers is associated with immune cell infiltration and immunomodulators and may provide a promising target for survival and immunotherapy. Our study shows that CD74 has an essential role as a biomarker of prognosis during tumor development, which highlights the possibility of new targeted therapies.
Optimization Strategies for Corrosion Management in Industries with Artificial Neural Network and Response Surface Technology: A Comprehensive Review
Authors: Kumari Preethi , Lavanya Mulky 
Published: June 2024

AbstractThe rising cases of corrosion problems in pipelines, refineries, water treatment and petrochemical plants, as well as in power generation plants in recent time have been attributed to industrialization. The longevity and dependability of essential assets must be ensured through effective corrosion management. The various techniques applied for corrosion protection are discussed in this review. But in recent years, the development of response surface methods (RSM) and artificial neural networks (ANN) has shown exciting prospects to transform the corrosion monitoring process. This review paper gives a thorough overview of corrosion optimisation strategies. The role of ANN and RSM in predicting corrosion using various parameters is discussed. By providing insights into the current state of research on ANN, this paper aims to promote a deeper understanding. The review emphasises how crucial it is to adequately manage corrosion if essential assets are to last a long time and function consistently.
A Qualitative Analysis of South African Pre-service Life Sciences Teachers’ Behavioral Intentions for Integrating AI in Teaching
Authors: Mnguni Lindelani 
Published: June 2024

AbstractThis paper explores pre-service life sciences teachers’ behavioral intentions toward integrating artificial intelligence into life sciences teaching. Despite the growing influence of AI in education, there is limited understanding of the factors affecting teachers’ willingness to integrate AI into life sciences teaching. These factors could inform policy-making and educational practice for AI adoption in the life sciences teaching. The current research aimed to identify key determinants influencing teachers’ behavioral intentions to adopt AI in life sciences teaching. The research followed a qualitative approach involving semi-structured interviews with 10 purposively selected pre-service life sciences teachers in South Africa. Thematic analysis was employed to analyze the data. The findings reveal that behavioral intentions are shaped by multiple factors within the framework of the Theory of Planned Behavior. Attitudes toward AI integration in life sciences education included themes such as pedagogical benefits, practical limitations, and philosophical concerns. Behavioral beliefs encompassed the advantages and disadvantages of AI adoption. Subjective norms highlighted inter-generational differences, administrative issues, stakeholder roles, and resource constraints. Normative beliefs included organizational authority, peer influence, parental concerns, and policy funding. The findings have important implications for policy and practice, highlighting the need for targeted training and resource allocation for effective AI integration in life sciences education.
Elucidating impact of solvent and pH in synthesizing silver nanoparticles via green and chemical route
Authors: Das Upama , Daimari Nikhil Kumar , Biswas Rajib , Mazumder Nirmal 
Published: June 2024

AbstractThis study reports synthesis of silver nanoparticles (AgNPs) in various solvent media namely, ethanol, propanol, acetone, ammonia, water, and N-Methyl-2-Pyrrolidone (NMP) by chemical and biosynthesized routes. The impact of solvent on the optical and structural characteristics of AgNPs were studied by using UV–Vis spectrophotometer and X-ray diffractometer respectively. AgNPs prepared via chemical route in the solvents water, NMP, and ethanol displayed significant absorbance peaks between 400 and 450 nm hinting formation of NPs. Meanwhile, in case of AgNPs prepared via biosynthesized route using Ocimum sanctum leaves extract, in solvent water, ethanol, acetone, and NMP, there emerged absorbance peaks between 400 and 470 nm. Furthermore, the silver precursor in NMP solvent without any reducing agent showed prominent absorbance peak at around 429 nm. XRD peaks provided confirmation of the crystalline nature of AgNPs exhibiting Face Centred Cubic (FCC) structure. The effect on optical properties were also studied by altering the pH before and after the synthesis. In essence, the study provides valuable insights into preparation of AgNPs using different solvents and pH conditions, which could be useful in various fields such as sensing, medicine, electronics, and catalysis.
Crowdsourcing the influence of physical features on the likely use of public open spaces
Authors: Milias Vasileios , Teeuwen Roos , Bozzon Alessandro , Psyllidis Achilleas 
Published: June 2024

AbstractThe configuration of public open spaces plays a crucial role in shaping how different people use them. Nevertheless, our understanding of how the physical features of public open spaces influence the activities conducted within them, and the extent to which this impact differs across various individuals and population groups, is currently limited. In this study, we explore how the physical characteristics of public open spaces influence the likelihood of use among individuals, spanning different age and gender groups. By employing crowdsourcing, street-level imagery, statistical comparisons, and reflexive thematic analysis we uncover significant variations in the suitability of public open spaces for distinct activities, such as socializing or exercising. Greenspaces emerge as the preferred choice for almost all activities, whereas streets are consistently rated as the least suitable. Additionally, we identified various characteristics that influence the activities people are likely to engage in. These include the size of the space, the presence of seating, natural elements such as vegetation or water bodies, and the proximity to transport infrastructure. Surprisingly, we do not observe statistically significant differences in preferences among most age and gender groups. Overall, our study underscores the need for providing a diverse range of public open spaces tailored to accommodate different individuals, population groups, and activities.
3-pre-Leibniz Algebras, Deformations and Cohomologies of Relative Rota-Baxter Operators on 3-Leibniz Algebras
Authors: Hu Meiyan , Hou Shuai , Song Lina , Zhou Yanqiu 
Published: June 2024

Abstract
In this paper, first we introduce the notions of 3-pre-Leibniz algebras and relative Rota-Baxter operators on 3-Leibniz algebras. We show that a 3-pre-Leibniz algebra gives rise to a 3-Leibniz algebra and a representation such that the identity map is a relative Rota-Baxter operator. Conversely, a relative Rota-Baxter operator naturally induces a 3-pre-Leibniz algebra. Then we construct a Lie 3-algebra, and characterize relative Rota-Baxter operators as its Maurer-Cartan elements. Consequently, we obtain the

$$L_\infty$$

L
∞

-algebra that controls deformations of relative Rota-Baxter operators on 3-Leibniz algebras. Next we define the cohomology of relative Rota-Baxter operators on 3-Leibniz algebras and show that infinitesimal deformations of a relative Rota-Baxter operator are classified by the second cohomology group. Finally, we construct an

$$L_\infty$$

L
∞

-algebra whose Maurer-Cartan elements are relative Rota-Baxter 3-Leibniz algebra structures, and define the cohomology of relative Rota-Baxter 3-Leibniz algebras.
From data to decisions: evaluating flood vulnerability in the Sindh watershed through Analytical Hierarchy Process
Authors: Sofi Mohd Sharjeel , Rautela Kuldeep Singh , Muslim Mohd , Bhat Sami Ullah 
Published: June 2024

AbstractFloods are recurrent global catastrophes causing substantial disruptions to human life, extensive land degradation, and economic losses. This study aims to identify flood-triggering watershed features and employ a Multi-Criteria Decision-Making (MCDM) approach based on the Analytical Hierarchy Process (AHP) model to delineate flood-prone zones. Weights for various flood-influencing factors (slope, rainfall, drainage density, land-use/land-cover, geology, elevation, and soil) were derived using a 7 × 7 AHP decision matrix, reflecting their relative importance. A Consistency Ratio (CR) of 0.089 (within acceptable limits) confirms the validity of the assigned weights. The analysis identified approximately 128.51 km2 as highly vulnerable to flooding, particularly encompassing the entire stretch of riverbanks within the watershed. Historically, snow avalanches and flash floods have been the primary water-related disasters in the region, posing significant threats to critical infrastructure. In this context, this model-based approach facilitates the proactive identification of susceptible areas, thereby promoting improved flood risk mitigation and response strategies.
Adenine base editor corrected ADPKD point mutations in hiPSCs and kidney organoids
Authors: Wang Jingwen , Qiu Yanling , Zhang Lei , Zhou Xinyao , Hu Sihui , Liu Qianyi , Yin Sisi , Su Zehong , Liu Simiao , Liu Haiying , Wu Xueqing , Huang Junjiu 
Published: June 2024

AbstractAutosomal dominant polycystic kidney disease (ADPKD) is a dominant genetic disorder caused primarily by mutations in the PKD1 gene, resulting in the formation of numerous cysts and eventually kidney failure. However, there are currently no gene therapy studies aimed at correcting PKD1 gene mutations. In this study, we identified two mutation sites associated with ADPKD, c.1198 (C > T) and c.8311 (G > A), which could potentially be corrected by adenine base editor (ABE). The correction efficiencies of different ABE variants were tested using the HEK293T-PKD1 c.1198 (C > T) and HEK293T-PKD1 c.8311 (G > A) reporter cell lines. We then generated induced pluripotent stem cells (iPSCsmut/WT) from the peripheral blood mononuclear cells (PBMCs) of the heterozygous patient to develop a disease cell model. Since the iPSCsmut/WT did not exhibit a typical disease phenotype in stem cell status, differentiation into kidney organoids in vitro led to the expression of kidney organ-specific marker proteins. Stimulation of cAMP signaling with forskolin resulted in cystic expansion of renal epithelial tissue in iPSCmut/WT-derived kidney organoids, resembling the cystic phenotype observed in ADPKD patients. However, kidney organoids differentiated from ABE-corrected iPSCs did not display the cystic phenotype. Furthermore, we used a dual AAV split-ABEmax system as a therapeutic strategy and achieved an average editing efficiency of approximately 6.56% in kidney organoids. Overall, this study provides a framework for gene therapy targeting ADPKD through ABE single-base editing, offering promising prospects for future therapeutic interventions.