bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative Synthesis of 2‐Pyridones Through C—H/N—H Bond Functionalizations.
Authors: Ackermann Lutz , Lygin Alexander V. , Hofmann Nora 
Published: September 2011

AbstractThe reaction proceeds with complete regioselectivity when phenylalkylacetylenes (XIII) are applied.
ChemInform Abstract: Photochemical Intramolecular Cyclization of o‐Alkynylaryl Isocyanides with Organic Dichalcogenides Leading to 2,4‐Bischalcogenated Quinolines.
Authors: Mitamura Takenori , Iwata Kimiyo , Nomoto Akihiro , Ogawa Akiya 
Published: September 2011

AbstractThe method provides a new approach to 2,4‐bischalcogenated quinolines.
ChemInform Abstract: One‐Pot Synthesis of Imidazo[1,2‐a]pyridines from Benzyl Halides or Benzyl Tosylates, 2‐Aminopyridines and Isocyanides.
Authors: Adib Mehdi , Sheikhi Ehsan , Rezaei Narjes 
Published: September 2011

AbstractBenzyl halides (I) or ‐tosylates (V) are oxidized to aldehydes under mild Kornblum conditions which then undergo a three‐component reaction with various 2‐aminopyridines (II) and isocyanides (III) to afford title compounds (IV)/ (VI) in high yields.
ChemInform Abstract: Synthesis of Heterocycles Through a Ruthenium‐Catalyzed Tandem Ring‐Closing Metathesis/Isomerization/N‐Acyliminium Cyclization Sequence.
Authors: Ascic Erhad , Jensen Jakob F. , Nielsen Thomas E. 
Published: September 2011

AbstractDouble bonds created during ring‐closing metathesis isomerize to generate reactive iminium intermediates.
ChemInform Abstract: Improved Synthesis of Monoprotected 5‐ and 6‐Amino‐2‐azanorbornanes
Authors: Dacenko Oleksandr P. , Manoylenko Olga V. , Grygorenko Oleksandr O. , Mykhailiuk Pavel K. , Volochnyuk Dmitriy M. , Shishkin Oleg V. , Tolmachev Andrey A. 
Published: September 2011

Abstractas conformationally rigid diamine scaffolds in the design of neurokinin receptor antagonists
ChemInform Abstract: Synthesis, Structure—Activity Relationship of Novel Substituted 4H‐Chromen‐1,2,3,4‐tetrahydropyrimidine‐5‐carboxylates as Potential Antimycobacterial and Anticancer Agents.
Authors: Raju B. China , Rao R. Nageswara , Suman P. , Yogeeswari P. , Sriram D. , Shaik Thokhir Basha , Kalivendi Shasi Vardhan 
Published: September 2011

AbstractThe synthesis of a series of novel tetrahydropyrimidine derivatives and their screening for in vitro antimycobacterial activity as well as their cytotoxicity against three human cancer cell lines are described.
ChemInform Abstract: Benzothieno[3,2‐e][1,2,4]triazolo[4,3‐c]pyrimidines: Synthesis, Characterization, Antimicrobial Activity, and Incorporation into Solid Lipid Nanoparticles.
Authors: Panchamukhi Shridhar I. , Mulla Jameel Ahmed S. , Shetty Nitinkumar S. , Khazi Mohammed Iqbal A. , Khan Ashraf Y. , Kalashetti Mallikarjun B. , Khazi Imitiyaz Ahmed M. 
Published: September 2011

AbstractA variety of novel tetracyclic triazolothienopyrimidines (V) (8 examples) with promising antibacterial and antifungal activities is synthesized.
ChemInform Abstract: Selenium‐Catalyzed Reductive Cyclization and Carbocyclization of 2,2′‐Dinitrostilbenes with Carbon Monoxide: One‐Shot Synthesis of Indolo[1,2‐c]quinazolinones.
Authors: Umeda Rui , Morishita Shigeru , Nishiyama Yutaka 
Published: September 2011

AbstractA practical and selective synthesis of the compounds (III) and (V) is developed.
ChemInform Abstract: Direct Synthesis of 6‐Azabicyclo[3.2.1]oct‐6‐en‐2‐ones and Pyrrolizidines from Divinyl Ketones and Observation of Remarkable Substituent Effects.
Authors: Xu Xianxiu , Li Yifei , Zhang Yu , Zhang Lingjuan , Pan Ling , Liu Qun 
Published: September 2011

AbstractDBU‐catalyzed treatment of divinyl ketones with isocyanoacetate at 0 or 25 °C allows a new, mild, easy, and stereoselective access to azabicyclooctenones.
ChemInform Abstract: Amberlyst‐15‐Catalyzed Facile Synthesis of α‐Amino Phosphonates.
Authors: Sudhakar Dega , Siddaiah Vidavalur , Rao Chunduri Venkata 
Published: September 2011

AbstractA facile method for the synthesis of the title compounds (III) under mild reaction conditions from N‐tosyl aldimines and phosphite (II) using Amberlyst 15 as heterogeneous catalyst is presented.
ChemInform Abstract: Synthesis and Structure Elucidation of Benzoylated Deoxyfluoropyranosides.
Authors: Esmurziev Aslan M. , Simic Nebojsa , Hoff Baard Helge , Sundby Eirik 
Published: September 2011

AbstractThe fluorination of several benzoylpyranosides using DAST and Deoxo‐Fluor is reported.
ChemInform Abstract: Regioselective NaBH4 and DIBAL‐H Reductions of 3,4‐Dimethoxyhomopiperonylphthalimide: Concise and Efficient Synthesis of Nuevamine and Isonuevamine.
Authors: Wakchaure Prasad B. , Kunte Sunita S. , Argade Narshinha P. 
Published: September 2011

AbstractThe ratio of the formation of nuevamine (IV) and isonuevamine (V) from (III) is strongly dependent on the reducing agent used.
ChemInform Abstract: Inhibition and Structural Reliability of Prenylated Flavones from the Stem Bark of Morus lhou on β‐Secretase (BACE‐1).
Authors: Cho Jung Keun , Ryu Young Bae , Curtis‐Long Marcus J. , Kim Ji Young , Kim Doman , Lee Sun , Lee Woo Song , Park Ki Hun 
Published: September 2011

AbstractA variety of flavones (8 examples) is isolated by activity‐guided fractionation of the methanolic extracts from Morus Ihou stem bark.
ChemInform Abstract: Formation and Hydrolysis of Polynuclear Actinide Complexes
Authors: Walther C. , Buchner S. , Fuss M. , Geist A. , Icker M. , Lutzenkirchen J. , Rothe J. , Schimmelpfennig B. , Schwindt O. , Steppert M. 
Published: September 2011

AbstractReview: 11 refs.
ChemInform Abstract: Transition Metals in Organic Synthesis. Part 93. Total Synthesis of Biologically Active Alkaloids Using Transition Metals
Authors: Forke Ronny , Gruner Konstanze K. , Knott Kerstin E. , Auschill Stefan , Agarwal Sameer , Martin Rene , Boehl Markus , Richter Sabine , Tsiavaliaris Georgios , Fedorov Roman , et al. et al. 
Published: September 2011

AbstractReview: 92 refs.
Comparison of Electrocardiographic Findings Between the Midventricular Ballooning Form and Apical Ballooning Form of Takotsubo Cardiomyopathy
Authors: Kurisu Satoshi , Kato Yasuko , Mitsuba Naoya , Ishibashi Ken , Dohi Yoshihiro , Nishioka Kenji , Kihara Yasuki 
Published: September 2011

AbstractBackground:Several reports have recently described the variant form of takotsubo cardiomyopathy exhibiting midventricular ballooning. The purpose of this study was to assess electrocardiographic (ECG) findings on admission in patients with midventricular ballooning.Hypothesis:ECG findings are different between the midventricular ballooning form and apical ballooning form of takotsubo cardiomyopathy.Methods:We reviewed ECGs on admission in 6 patients with midventricular ballooning and 20 patients with apical ballooning. The sum of ST segment elevation in leads V1 to V3 or in leads V4 to V6 was obtained. The number of leads showing ST segment elevation and/or T wave inversion was also obtained. These ECG findings were compared between the 2 groups.Results:In midventricular ballooning, ECG changes including ST segment elevation and/or T wave inversion were observed frequently in leads V2 and V3, and were not observed in leads II, III, −aVR, aVF, V5, and V6. On the other hand, in apical ballooning, they were found in all leads. They were most common in leads V4 and V5. The sum of ST segment elevation in leads V1 to V3 was similar (2.6 ± 2.0 mm vs 2.7 ± 2.0 mm, P = not significant), and the sum of ST segment elevation in leads V4 to V6 was significantly lower in midventricular ballooning than apical ballooning (0.4 ± 0.8 mm vs 3.5 ± 3.0 mm, P<0.05). The number of leads showing ST segment elevation and/or T wave inversion was significantly lower in midventricular ballooning than apical ballooning (3.2 ± 1.0 leads vs 6.3 ± 2.2 leads, P<0.01).Conclusions:Our data suggested that midventricular ballooning may show limited ECG changes despite broad wall motion abnormality. © 2011 Wiley Periodicals, Inc.The authors have no funding, financial relationships, or conflicts of interest to disclose.
What Do the 2011 American Heart Association Guidelines Tell Us About Prevention of Cardiovascular Disease in Women?
Authors: Wenger Nanette K. 
Published: September 2011

AbstractThe 2011 Update of the American Heart Association's Cardiovascular Disease Prevention Guideline for Women is designed to help women and their physicians understand cardiovascular Disease (CVD) risks and undertake practical steps that are most effective in preventing heart disease and stroke. Defining a woman's risk status and improving her adherence to preventive lifestyle behaviors and medications is the best strategy to lower the burden of CVD in women. © 2011 Wiley Periodicals, Inc.The author has no funding or financial relationships of interest to disclose. Author is also author of the Guideline.
Synthesis and Anti‐HIV Activity of Aryl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone hydrazones as Potent Non‐nucleoside Reverse Transcriptase Inhibitors
Authors: Ma Xiao‐Dong , Yang Shi‐Qiong , Gu Shuang‐Xi , He Qiu‐Qin , Chen Fen‐Er , De Clercq Erik , Balzarini Jan , Pannecouque Christophe 
Published: September 2011

AbstractA series of novel diarylpyrimidines (DAPYs) with a ketone hydrazone substituent on the methylene linker between the pyrimidine nucleus and the aryl moiety at the C‐4 position were synthesized, and their antiviral activity against human immunodeficiency virus (HIV)‐1 in MT‐4 cells was evaluated. Most compounds of this class exhibited excellent activity against wild‐type HIV‐1, with EC50 values in the range of 1.7–13.2 nM. Of these compounds, 2‐bromophenyl‐2‐[(4‐cyanophenyl)amino]‐4‐pyrimidinone hydrazone (9 k) displayed the most potent anti‐HIV‐1 activity (EC50=1.7±0.6 nM), with excellent selectivity for infected over uninfected cells (SI=5762). In addition, the 4‐methyl phenyl analogue 9 d (EC50=2.4±0.2 nM, SI=18461) showed broad spectrum HIV inhibitory activity, with EC50 values of 2.4±0.2 nM against wild‐type HIV‐1, 5.3±0.4 μM against HIV‐1 double‐mutated strain RES056 (K103N+Y181C), and 5.5 μM against HIV‐2 ROD strain. Furthermore, structure–activity relationship (SAR) data and molecular modeling results for these compounds are also discussed.
Cell labeling approaches for fluorescence‐based in vivo flow cytometry
Authors: Pitsillides Costas M. , Runnels Judith M. , Spencer Joel A. , Zhi Liang , Wu Mei X. , Lin Charles P. 
Published: September 2011

AbstractWe provide an overview of the methods used to label circulating cells for fluorescence detection by in vivo flow cytometry. These methods are useful for cell tracking in small animals without the need to draw blood samples and are particularly useful for the detection of circulating cancer cells and quantification of circulating immune cells. © 2011 International Society for Advancement of Cytometry.
A high‐resolution molecular atlas of the fetal mouse lower urogenital tract
Authors: Abler Lisa L. , Keil Kimberly P. , Mehta Vatsal , Joshi Pinak S. , Schmitz Christopher T. , Vezina Chad M. 
Published: September 2011

AbstractEpithelial‐stromal interactions in the lower urogenital tract (LUT) are integral to prostatic and seminal vesicle development in males, vaginal and uterine development in females, and urethral development in both sexes. Gene expression profiling of isolated LUT stroma and epithelium has unraveled mechanisms of LUT development, but such studies are confounded by heterogeneous and ill‐defined cell sub‐populations contained within each tissue compartment. We used in situ hybridization to synthesize a high‐resolution molecular atlas of 17‐day post‐coitus fetal mouse LUT. We identified mRNAs that mark selective cell populations of the seminal vesicle, ejaculatory duct, prostate, urethra, and vagina, subdividing these tissues into 16 stromal and 8 epithelial sub‐compartments. These results provide a powerful tool for mapping LUT gene expression patterns and also reveal previously uncharacterized sub‐compartments that may play mechanistic roles in LUT development of which we were previously unaware. Developmental Dynamics 240:2364–2377, 2011. © 2011 Wiley‐Liss, Inc.
Summary of ‘Combined oral contraceptive pills for treatment of acne’
Authors: Editorial Office Evidence‐Based Child Health 
Published: September 2011

AbstractThis is a summary of Cochrane review, published in this issue of EBCH, first published as: Arowojolu AO, Gallo MF, Lopez LM, Grimes DA, Garner SE. Combined oral contraceptive pills for treatment of acne. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD004425. DOI: 10.1002/14651858.CD004425.pub4.acne Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. The Cochrane Collaboration
Variation in MHC genotypes in two populations of house sparrow (Passer domesticus) with different population histories
Authors: Borg Åsa Alexandra , Pedersen Sindre Andre , Jensen Henrik , Westerdahl Helena 
Published: September 2011

AbstractSmall populations are likely to have a low genetic ability for disease resistance due to loss of genetic variation through inbreeding and genetic drift. In vertebrates, the highest genetic diversity of the immune system is located at genes within the major histocompatibility complex (MHC). Interestingly, parasite‐mediated selection is thought to potentially maintain variation at MHC loci even in populations that are monomorphic at other loci. Therefore, general loss of genetic variation in the genome may not necessarily be associated with low variation at MHC loci. We evaluated inter‐ and intrapopulation variation in MHC genotypes between an inbred (Aldra) and a relatively outbred population (Hestmannøy) of house sparrows (Passer domesticus) in a metapopulation at Helgeland, Norway. Genomic (gDNA) and transcribed (cDNA) alleles of functional MHC class I and IIB loci, along with neutral noncoding microsatellite markers, were analyzed to obtain relevant estimates of genetic variation. We found lower allelic richness in microsatellites in the inbred population, but high genetic variation in MHC class I and IIB loci in both populations. This suggests that also the inbred population could be under balancing selection to maintain genetic variation for pathogen resistance.
Development and validation of a capillary electrophoresis assay for the determination of the stereoisomeric purity of chloroquine enantiomers
Authors: Wongwan Sudaporn , Scriba Gerhard K. E. 
Published: September 2011

AbstractA stereoselective CE assay for the determination of the enantiomeric purity of (R)‐(−)‐chloroquine and (S)‐(+)‐chloroquine was developed and validated. The separations were performed in a 50.2/40 cm uncoated fused silica capillary at 20°C using a 100 mM sodium phosphate buffer, pH 2.5, containing 30 mg/mL sulfobutylether(VII)‐β‐cyclodextrin as background electrolyte operated at an applied voltage of –25 kV and 20°C. The detection wavelength was 225 nm. Carbamazepine was used as internal standard. The assay was validated in the range of 0.05–1.0% for the respective minor chloroquine enantiomer based on a concentration of 3 mg/mL of the major enantiomer, either (R)‐(−)‐chloroquine or (S)‐(+)‐chloroquine. The method was applied to analyze the stereoisomeric purity of synthetic samples of the chloroquine enantiomers.
Capillary electrophoresis and hollow fiber liquid‐phase microextraction for the enantioselective determination of albendazole sulfoxide after biotransformation of albendazole by an endophytic fungus
Authors: Carrão Daniel B. , Borges Keyller B. , Barth Thiago , Pupo Mônica T. , Bonato Pierina S. , de Oliveira Anderson R. Moraes 
Published: September 2011

AbstractHollow fiber liquid‐phase microextraction and CE were applied for the determination of albendazole sulfoxide (ASOX) enantiomers in liquid culture medium after a fungal biotransformation study. The analytes were extracted from 1 mL of liquid culture medium spiked with the internal standard (rac‐hydroxychloroquine) and buffered with 0.50 mol/L phosphate buffer, pH 10. The analytes were extracted into 1‐octanol impregnated in the pores of the hollow fiber, and into an acid acceptor solution inside the polypropylene hollow fiber. The electrophoretic separations were carried out in 0.05 mol/L tris(hydroxymethyl)aminomethane buffer, pH 9.3, containing 3.0% w/v sulfated‐β‐CD (S‐β‐CD) with a constant voltage of +15 kV and detection at 220 nm. The method was linear over the concentration range of 250–5000 ng/mL for each ASOX enantiomer. Within‐day and between‐day assay precision and accuracy for the analytes were studied at three concentration levels and the values of RSD% and relative error % were lower than 15%. The developed method was applied for the determination of ASOX after a biotransformation study employing the endophytic fungus Penicillium crustosum (VR4). This study showed that the endophytic fungus was able to metabolize the albendazole to ASOX enantioselectively. In addition, it was demonstrated that hollow fiber liquid‐phase microextraction coupled to CE can be an excellent and environmentally friendly technique for the analysis of samples obtained in biotransformation studies.
Survival of patients with incident dementia who had a pre‐existing psychiatric disorder: a population‐based 7‐year follow‐up study
Authors: Meng Xiangfei , D'Arcy Carl , Tempier Raymond , Kou Changgui , Morgan Debra , Mousseau Darrell D. 
Published: September 2011

ObjectivesAlthough it is widely accepted that psychiatric disorders and dementia coexist and survival data for dementia patients have been published, there is a paucity of information regarding the survival of patients with a psychiatric disorder who develop dementia. This study fills this information gap providing survival data on patients with such comorbidity and identifies mortality risk factors.MethodsAll residents of Saskatchewan, a Canadian province, diagnosed with psychiatric problems and/or dispensed a psychiatric drug in 2000 and without dementia were followed through to 31 December 2006; the development of incident dementia was noted. Median survival time (in months) and selected predictors of mortality were measured. Analyses used Cox's proportional hazard model. Incidence density of dementia for the year 2000 was also computed.ResultsBy December 2006, 5,583 subjects with psychiatric disorders in 2000 had been diagnosed with incident dementia, and 60.65% of them died. Dementia‐incidence density in this population for 2000 was 0.01 per 1000 person years at risk among those aged 18–64 years and rapidly increased to 3.13 per 1000 person years at risk among those aged 75 to 84 years. The median survival time from dementia onset to death was 32.66 months (interquartile range 31.21–34.14). Being male, later age of onset of dementia, having a lower income, and a high chronic disease score predicted shorter survival.ConclusionsThe comorbidity of psychiatric disorders and dementia resulted in shorter survival compared with that reported for patients with dementia only. These findings can be used for prognosis for patients, caregivers, and service providers. Copyright © 2011 John Wiley & Sons, Ltd.
An overview of therapies to promote repair of the brain after stroke
Authors: Cramer Steven C. 
Published: September 2011

AbstractStroke remains a leading cause of disability. Most patients show some degree of spontaneous recovery, but this is generally incomplete. Studies on the neurobiology of this recovery are providing clues to therapeutic interventions that aim to improve patient outcomes. A number of potential such restorative therapies are reviewed. Numerous treatment strategies are under study. Most have a time window measured in days or weeks and so have the potential to help a large fraction of patients. This review considers these therapies, as well as points to consider in translating their application to human trials. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Swallow remodeling of respiratory neural networks
Authors: Davenport Paul W. , Bolser Donald C. , Morris Kendall F. 
Published: September 2011

AbstractSwallow is defined as the coordinated neuromuscular activity of the mouth, pharynx, larynx, and esophagus. Movement of a bolus and air must be coordinated by swallow remodeling of the respiratory pattern. The brainstem contains respiratory and swallow neural control networks that generate the pattern for breathing and swallow. Swallow control of respiration is proposed to be through recruitment of swallow neural elements that retask existing respiratory neural network elements. Swallow reconfiguration of the respiratory neural network is fundamental to airway protection and integrated with other airway protective reflexes. Thus, swallow, breathing, cough, and other airway defensive behaviors are produced by a central neural motor system that shares elements. It is hypothesized that swallow and airway defensive behaviors are controlled by a recruited behavioral control assembly system that is organized in a fashion that allows for precise coordination of the expression of these behaviors to maintain airway protection. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
Functional MRI of swallowing: From neurophysiology to neuroplasticity
Authors: Malandraki Georgia A. , Johnson Sterling , Robbins JoAnne 
Published: September 2011

AbstractSwallowing is a complex neurogenic sensorimotor process involving all levels of the neuraxis and a vast number of muscles and anatomic structures. Disruption of any of these anatomic or functional components can lead to swallowing disorders (also known as dysphagia). Understanding the neural pathways that govern swallowing is necessary in diagnosing and treating patients with dysphagia. Functional MRI (fMRI) is a prevalent and effective neuroimaging method that has been used to study the complex neurophysiologic control of swallowing in vivo. This article presents a summary of the research studies that have used fMRI to study the neural control of swallowing in normal subjects and dysphagic patients, and to investigate the effects of swallowing treatments on neuroplasticity. Methodologic challenges and caveats are discussed, and a case study of a pre‐posttreatment paradigm is presented to highlight potential future directions of fMRI applications in swallowing research and clinical practice. © 2011 Wiley Periodicals, Inc. Head Neck, 2011
The effect of 90 day administration of a high dose vitamin B‐complex on work stress
Authors: Stough Con , Scholey Andrew , Lloyd Jenny , Spong Jo , Myers Stephen , Downey Luke A. 
Published: September 2011

ObjectiveOccupational stress is increasing in Western societies and the impact is significant at a personal, organisational and community level. The present study examined for the first time the efficacy of 3 months administration of two forms of high dose vitamin B complex on mood and psychological strain associated with chronic work stress.MethodSixty participants completed the 3‐month, double‐blind, randomised, placebo‐controlled trial in which personality, work demands, mood, anxiety and strain were assessed.ResultsAfter individual differences in personality and work demands were statistically controlled, the vitamin B complex treatment groups reported significantly lower personal strain and a reduction in confusion and depressed/dejected mood after 12 weeks. There were no treatment‐related changes in other measures of mood and anxiety.DiscussionThe results of the study are consistent with two previous studies examining multivitamin supplementation and personal (non‐work) feelings of strain and suggestive of significant decreases in the experience of workplace stress after 90 day supplementation of a B multivitamin.ConclusionGiven the direct and indirect costs of workplace stress, these findings point to the utility of a cost‐effective treatment for the mood and psychological strain effects of occupational stress. These findings may have important personal health, organisational and societal outcomes given the rising cost and incidence of workplace stress. Copyright © 2011 John Wiley & Sons, Ltd.