bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seed‐Mediated and Iodide‐Assisted Synthesis of Gold Nanocrystals with Systematic Shape Evolution from Rhombic Dodecahedral to Octahedral Structures
Authors: Chung Pei‐Ju , Lyu Lian‐Ming , Huang Michael H. 
Published: July 2011

AbstractWe report the development of a seed‐mediated and iodide‐assisted method for the synthesis of monodisperse gold nanocrystals with systematic shape evolution from rhombic dodecahedral to octahedral structures. Particle growth is complete in 15 min at room temperature, so the process is fast and energy‐efficient. By progressively increasing the volume of KI used in a growth solution while keeping the amount of ascorbic acid added constant, nanocrystals with morphologies that vary from rhombic dodecahedral to rhombicuboctahedral, edge‐ and corner‐truncated octahedral, corner‐truncated octahedral, and octahedral structures were synthesized. The nanocrystals are monodisperse in size and readily form self‐assembled structures on substrates. By simply adjusting the volume of gold seed solution added to a growth solution, particle sizes of the octahedral gold nanocrystals can be tuned with average opposite corner‐to‐corner distances of 42, 48, 54, 60, 68, 93, 107, and 125 nm. In the presence of HAuCl4, iodide may act as a reducing agent. Variation of its volume in the solution may slightly modulate the reduction rate and affect the final crystal morphology. Intermediate structures collected during crystal growth reveal the presence of many twisted structures that surround a developing nanocrystal core. This nanocrystal growth mechanism and the less important role of surfactant in directing the polyhedral nanocrystal morphology is discussed.
ChemInform Abstract: Layered Perovskite‐Like Pb2Fe2O5 Structure as a Parent Matrix for the Nucleation and Growth of Crystallographic Shear Planes.
Authors: Batuk Dmitry , Hadermann Joke , Abakumov Artem , Vranken Thomas , Hardy An , Van Bael Marlies , Van Tendeloo Gustaaf 
Published: July 2011

AbstractThe incommensurate title compound is synthesized by solid state reaction of PbO and Fe2O3 (700—800 °C, up to 500 h) and characterized by powder XRD and TEM.
ChemInform Abstract: Pd‐Catalyzed Carbonylation of Diazo Compounds at Atmospheric Pressure: A Catalytic Approach to Ketenes.
Authors: Zhang Zhenhua , Liu Yiyang , Ling Lin , Li Yuxue , Dong Yian , Gong Mingxing , Zhao Xiaokun , Zhang Yan , Wang Jianbo 
Published: July 2011

AbstractThe first efficient Pd‐catalyzed carbonylation of α‐diazo carbonyl compounds or N‐tosylhydrazones with CO is reported.
ChemInform Abstract: Intramolecular Michael Reactions of Aliphatic Aldehyde Enolates Generated by Imidazolium Carbenes.
Authors: Kim Hyoungsu , Byeon Seong Rim , Leed Marina G. D. , Hong Jiyong 
Published: July 2011

AbstractThe reaction is investigated with respect to the synthesis of cyclopentane aldehydes.
ChemInform Abstract: Iridium‐Catalyzed Intramolecular Asymmetric Allylic Dearomatization of Phenols.
Authors: Wu Qing‐Feng , Liu Wen‐Bo , Zhuo Chun‐Xiang , Rong Zi‐Qiang , Ye Ke‐Yin , You Shu‐Li 
Published: July 2011

AbstractSpirocyclohexadienone derivatives are obtained in high yields and enantioselectivities by intramolecular asymmetric allylic dearomatization of phenols bearing tethered allylic ethers.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling Reactions of 2‐Diazonaphthoquinones with Arylboronic Acids.
Authors: Kitamura Mitsuru , Sakata Rie , Okauchi Tatsuo 
Published: July 2011

AbstractUnsubstituted diazonaphthoquinone (I) reacts with various boronic acids under the optimized conditions to produce the target compounds in moderate to good yield in dependence of the aryl substituents.
ChemInform Abstract: An Efficient Methodology to Substituted Furans via Oxidation of Functionalized α‐Diazo‐β‐ketoacetates.
Authors: Truong Phong , Xu Xinfang , Doyle Michael P. 
Published: July 2011

AbstractOxidative cyclization of α‐diazoesters of type (I) and subsequent dehydration offers an efficient access to 3‐methoxyfuran carboxylate esters (IV) and an improved method for the synthesis of 3‐hydrofuran carboxylate esters (V).
ChemInform Abstract: One‐Pot Nitro‐Mannich/Hydroamination Cascades for the Direct Synthesis of 2,5‐Disubstituted Pyrroles Using Base and Gold Catalysis.
Authors: Barber David M. , Sanganee Hitesh , Dixon Darren J. 
Published: July 2011

AbstractAn efficient method for the preparation of substituted pyrroles (IV) from sulfonyl imines (I) and nitrobutyne (II) is presented.
ChemInform Abstract: Regioselective Synthesis of 2,3,4‐ or 2,3,5‐Trisubstituted Pyrroles via [3,3] or [1,3] Rearrangements of O‐Vinyl Oximes.
Authors: Wang Heng‐Yen , Mueller Daniel S. , Sachwani Rachna M. , Kapadia Rachel , Londino Hannah N. , Anderson Laura L. 
Published: July 2011

AbstractO‐Vinyl oximes, generated by Ir‐catalyzed isomerization of O‐allyl oximes, undergo efficient cyclization to afford 2,3,4‐ trisubstituted pyrroles via [3,3] rearrangement or 2,5‐di‐ and 2,3,5‐trisubstituted pyrroles via [1,3] rearrangement.
ChemInform Abstract: Synthesis and Blocking Activities of Isoindolinone‐ and Isobenzofuranone‐Containing Phenoxylalkylamines as Potent α1‐Adrenoceptor Antagonists.
Authors: Zhang Shou‐Hua , Wang Chun‐Ye , Jiang Zhen‐Zhou , Ni Pei‐Zhou , Zhou Jin‐Pei , Xi Bao‐Min , Chen Wen‐Hua 
Published: July 2011

AbstractNew isoindolinone‐ and isobenzofuranone‐containing phenoxyalkylamines (V) and (VIII), resp., are synthesized and evaluated for their blocking activities toward α1‐adrenoceptors.
ChemInform Abstract: Sonogashira Coupling Offers a New Synthetic Route to Thieno[2,3‐c]pyrazoles.
Authors: Eller Gernot A. , Vilkauskaite Gyte , Arbaciauskiene Egle , Sackus Algirdas , Holzer Wolfgang 
Published: July 2011

AbstractA short synthetic route to the title compounds (IV) is presented.
ChemInform Abstract: Regio‐ and Stereoselectivity of Cycloaddition of C‐Amidonitrones to Esters of Methylenecyclopropanedicarboxylic Acids.
Authors: Molchanov A. P. , Tung Tran Q. , Kostikov R. R. 
Published: July 2011

AbstractDiarylnitrones with electron‐demanding aryl substituents are not suitable as starting material.
ChemInform Abstract: Efficient 2,4,6‐Trichloro‐1,3,5‐triazine‐Catalyzed Synthesis of 2‐Arylbenzothiazoles and Bisbenzothiazoles by Condensation of 2‐Aminothiophenol with Aldehydes under Mild Conditions.
Authors: Maleki Behrooz , Azarifar Davood , Hojati Seyede Fateme , Veisi Hojat , Gholizadeh Mostafa , Salehabadi Hafezeh , Moghadam Mona Khodaverdian 
Published: July 2011

AbstractA reaction mechanism with in situ generated HCl as primary promoter is proposed.
ChemInform Abstract: One‐Pot Chemoselective Synthesis of Different Pyrano‐pyrazole Derivatives.
Authors: Heravi Majid M. , Saeedi Mina , Beheshtiha Yahya S. , Oskooie Hossein A. 
Published: July 2011

AbstractIf the reaction is carried out under microwave conditions and in the presence of sulfamic acid compounds (V) are formed as well.
ChemInform Abstract: Studies with 2‐(Acetonylthio)benzothiazole: Novel Synthesis of Pyridazin‐6(1H)‐one, Pyridazin‐6(1H)‐imine, and Phthalazine Derivatives of Antimicrobial and Antifungal Activities.
Authors: Al‐Omran Fatima A. , El‐Khair Adel A. 
Published: July 2011

AbstractNovel (2)‐arylhydrazonopropan‐2‐ones (III) are synthesized and utilized as building blocks for the synthesis of new pyridazine and phthalazine derivatives.
ChemInform Abstract: Identification of Cyclicsulfonamide Derivatives with an Acetamide Group as 11β‐Hydroxysteroid Dehydrogenase 1 Inhibitors.
Authors: Ahn Jin Hee , et al. et al. 
Published: July 2011

AbstractA series of cyclic sulfonamide derivatives (IX) (31 examples) with an acetamide group in the 2‐position are synthesized and evaluated for their ability to inhibit 11β‐HSD1.
ChemInform Abstract: Reactions of 1,3,5‐Triazinylnitroformaldoximes. Part 3. Interaction of 1,3,5‐Triazinylnitroformaldoximes with Malonic Acid Esters
Authors: Bakharev V. V. , Gidaspov A. A. , Selezneva E. V. , Ul'yankina I. V. , Krivolapov D. B. , Litvinov I. A. , Eltsov O. S. 
Published: July 2011

Abstractformation of a zwitterionic triazinylisoxazolone (III)
ChemInform Abstract: Thiamine Hydrochloride (VB1): An Efficient Catalyst for One‐Pot Synthesis of α‐Aminophosphonates under Ultrasonic Irradiation.
Authors: Mandhane Priyanka G. , Joshi Ratnadeep S. , Nagargoje Deepak R. , Gill Charansingh H. 
Published: July 2011

AbstractThe process works well with aromatic aldehydes.
Two Unprecedented Entangled Metal–Olsalazine Complexes with Coexistence of 2D → 3D Polycatenation and meso‐Helix
Authors: Xiao Dong‐Rong , Sun Dian‐Zhen , Liu Jun‐Liang , Zhang Guang‐Ju , Chen Hai‐Yan , He Jiang‐Hong , Yan Shi‐Wei , Yuan Ruo , Wang En‐Bo 
Published: July 2011

AbstractRational self‐assembly of the anti‐inflammatory drug olsalazine (H4osa) with a cobalt salt in the presence of linear bidentate ligands yields two novel metal–drug complexes[Co(H2osa)(bpp)] (1) and [Co2(osa)(bpy)2(H2O)4] (2) [bpp = 1,3‐bis(4‐pyridyl)propane, bpy = 4,4′‐bipyridine]. Their structures were determined by single‐crystal X‐ray diffraction and further characterized by elemental analysis, IR spectroscopy, X‐ray powder diffraction, and thermogravimetric analysis (TGA). Compound 1 displays a new 2D → 3D parallel polycatenation of undulating (4,4) layers, whereas 2 exhibits an unusual 2D → 3D inclined polycatenation of (6,3) layers. To the best of our knowledge, they represent the first examples of metal–drug complexes that have both polycatenane and meso‐helix characteristics. The magnetic properties of 1 and 2 have been studied by measuring their magnetic susceptibility in the temperature range of 2–300 K.
A Practical Solvating Agent for the Chiral NMR Discrimination of Carboxylic Acids
Authors: Kim Seon‐mi , Choi Kihang 
Published: July 2011

AbstractA bisimidazoline compound has been prepared as a new chiral solvating agent starting from isophthalaldehyde and (S,S)‐1,2‐diphenylethylenediamine through a single‐step synthesis. In the presence of one equivalent of this reagent, carboxylic acid racemates show 1H NMR chemical shift nonequivalences large enough for the discrimination of the enantiomers. Studies with related compounds showed that the 1,3‐disubstituted structure is crucial for the acid‐solvating ability of the bisimidazoline compound.
Photoperiodic regulation of glycogen metabolism, glycolysis, and glutamine synthesis in tanycytes of the Siberian hamster suggests novel roles of tanycytes in hypothalamic function
Authors: Nilaweera Kanishka , Herwig Annika , Bolborea Matei , Campbell Gill , Mayer Claus D. , Morgan Peter J. , Ebling Francis J. P. , Barrett Perry 
Published: July 2011

AbstractThe objective of this study is to investigate the impact of photoperiod on the temporal and spatial expression of genes involved in glucose metabolism in the brain of the seasonal mammal Phodopus sungorus (Siberian hamster). In situ hybridization was performed on brain sections obtained from male hamsters held in long photoperiod (high body weight and developed testes) or short photoperiod (reduced body weight with testicular regression). This analysis revealed upregulation in expression of genes involved in glycogen and glucose metabolism in short photoperiod and localized to the tanycyte layer of the third ventricle. On the basis of these data and a previously identified photoperiod‐dependent increase in activity of neighboring hypothalamic neurons, we hypothesized that the observed expression changes may reflect alteration in either metabolic fuel or precursor neurotransmitter supply to surrounding neurons. Gene expression analysis was performed for genes involved in lactate and glutamate transport. This analysis showed that the gene for the lactate transporter MCT2 and glutamate transporter GLAST was decreased in the tanycyte layer in short photoperiod. Expression of mRNA for glutamine synthetase, the final enzyme in the synthesis of the neuronal neurotransmitter precursor, glutamine, was also decreased in short photoperiod. These data suggest a role for tanycytes in modulating glutamate concentrations and neurotransmitter supply in the hypothalamic environment. © 2011 Wiley‐Liss, Inc.
Three New Diterpenoids from Isodon nervosus
Authors: Wei Zhi‐Xiong , Gao You‐Heng , Yang Fen , Lu Hai‐Xiao , Ni Lin , Zhou Xiao‐Hong 
Published: July 2011

AbstractThree new ent‐kaurane diterpenoids, rabdonervosins D–F (1–3), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated on the basis of spectroscopic methods including 1D‐ and 2D‐NMR analyses. Compounds 1–3 were evaluated for their cytotoxicity against HepG2, CNE2, PC‐9/ZD, HeLa, MCF‐7, and HCT116 cell lines. No compounds exhibited potent cytotoxicity.
Synthesis of 2,3‐Diaryl‐3H‐pyrrolo[2,3‐c]pyridin‐3‐ol Derivatives by the Reaction of Aryl(3‐isocyanopyridin‐4‐yl)methanones with Aryl Grignard Reagents
Authors: Kobayashi Kazuhiro , Kozuki Taketoshi , Konishi Manami , Suzuki Teruhiko , Tanmatsu Miyuki , Konishi Hisatoshi 
Published: July 2011

AbstractThe reaction of aryl(3‐isocyanopyridin‐4‐yl)methanones 1, easily prepared from commercially available pyridin‐3‐amine, with aryl Grignard reagents gave, after aqueous workup, 2,3‐diaryl‐3H‐pyrrolo[2,3‐c]pyridin‐3‐ols 2. These rather unstable alcohols were O‐acylated with Ac2O in pyridine in the presence of a catalytic amount of 4‐(dimethylamino)pyridine (DMAP) to afford the corresponding 2,3‐diaryl‐3H‐pyrrolo[2,3‐c]pyridin‐3‐yl acetates 3 in relatively good yields.
“Activation of tissue tranglutsaminase by removal of carboxyl‐terminal peptides”
Authors: Fraij Bassam M. 
Published: July 2011

AbstractTissue transglutaminase (TGC or TG2) functions as transglutaminase (cross‐linking), deamidase, kinase, and disulfide isomerase and its activities are implicated in the pathogenesis of several human diseases. Proteolytic activation of zymogens in the transglutaminase family is not unusual. Plasma transglutaminase (FXIIIa), epidermal transglutaminase (TG 3), transglutaminase‐5, and microbial transglutaminase (MTG) can be subjected to proteolysis from specific proteases to generate the active functional enzyme. In the present study, calcium or GTP was essential for activation of TGC cross‐linking activity by trypsin in membrane fractions from human RBC and was accompanied by the conversion of TGC (80 kDa) to a smaller TG form (55 kDa). While bacterially expressed TGC showed no activity, bacterial expression of C‐terminal domain deletion constructs with carboxy‐terminal ends ranging from lysine 464 (TG464) to glycine 480 (TG480) produced enzymes that were highly active in cross‐linking activity. The product of a construct with a coding region ended at proline 446 (TG446), which interrupted the calcium‐binding domain, exhibited weak cross‐linking activity. TG480 and TG512 were characterized by about 80% and 10%, respectively, of the cross‐linking activities of TG464. This may indicate that the longer the peptide after the calcium binding domain, the less the enzymatic activity expressed, possibly because the folding of such peptide which interfere with the calcium binding site or the catalytic site. Western analysis of MCF7 and T47D human breast cancer cells transfected with TGC showed TGC as a major protein and TG as a minor fragment. Incubation of lysate from transfected cells with serum resulted in the conversion of the TGC to TG, a condition that may be comparable to injury or wounds that lead to rapid enzymatic transamidation activation. J. Cell. Biochem. 112: 3469–3481, 2011. © 2011 Wiley Periodicals, Inc.
Shear stress‐mediated F1/FO ATP synthase‐dependent CO2 gas excretion from human pulmonary arteriolar endothelial cells
Authors: Kawai Yoshiko , Yoshida Kazuo , Kaidoh Maki , Yokoyama Yumiko , Ohhashi Toshio 
Published: July 2011

AbstractWe studied the physiological role of flow through pulmonary arterioles in CO2 gas exchange. We established human pulmonary arteriolar endothelial cells (HPAoEC). The cells demonstrated marked immunocytochemical staining of PECAM‐1, VEGF R2, ACE‐1, and CA type IV on their cell surface. Ten seconds shear stress stimulation caused the co‐release of H+ and ATP via the activation of F1/FO ATP synthase on the HPAoEC. F1/FO ATP synthase was immunocytochemically observed on the cell surface of non‐permeabilized HPAoEC. In the shear stress‐loaded HPAoEC culture media supernatant, ATPase activity increased in a time‐dependent manner. The HPAoEC were strongly stained for NTPDase 1, which partially co‐localized with purinergic P2Y1. The purinergic P2Y1 receptor agonist UTP (10−6 M) significantly potentiated the shear stress‐induced increase in ATPase activity in the culture medium supernatant. Ten seconds shear stress stimulation also produced stress strength‐dependent CO2 gas excretion from the HPAoEC, which was significantly reduced by the inhibition of F1/FO ATP synthase or CA IV on the endothelial cell (EC) surface. In conclusion, we have proposed a new concept of CO2 exchange in the human lung, flow‐mediated F1/FO ATP synthase‐dependent H+ secretion, resulting in the facilitation of a dehydration reaction involving ${\rm HCO}_{3}^{{-} } $ in plasma and the excretion of CO2 gas from arteriolar ECs. J. Cell. Physiol. 227: 2059–2068, 2012. © 2011 Wiley Periodicals, Inc.
MiR‐133a regulates collagen 1A1: Potential role of miR‐133a in myocardial fibrosis in angiotensin II‐dependent hypertension
Authors: Castoldi Giovanna , di Gioia Cira R.T. , Bombardi Camila , Catalucci Daniele , Corradi Barbara , Gualazzi Maria Giovanna , Leopizzi Martina , Mancini Massimiliano , Zerbini Gianpaolo , Condorelli Gianluigi , Stella Andrea 
Published: July 2011

AbstractMicroRNAs play an important role in myocardial diseases. MiR‐133a regulates cardiac hypertrophy, while miR‐29b is involved in cardiac fibrosis. The aim of this study was to evaluate whether miR‐133a and miR‐29b play a role in myocardial fibrosis caused by Angiotensin II (Ang II)‐dependent hypertension. Sprague–Dawley rats were treated for 4 weeks with Ang II (200 ng/kg/min) or Ang II + irbesartan (50 mg/kg/day in drinking water), or saline by osmotic minipumps. At the end of the experimental period, cardiac miR‐133a and miR‐29b expression was measured by real‐time PCR, and myocardial fibrosis was evaluated by morphometric analysis. A computer‐based prediction algorithm led to the identification of collagen 1a1 (Col1A1) as a putative target of miR‐133a. A reporter plasmid bearing the 3′‐untranslated regions (UTRs) of Col1A1 mRNA was constructed and luciferase assay was performed. MiR‐133a suppressed the activity of luciferase when the reporter gene was linked to a 3′‐UTR segment of Col1A1 (P < 0.01). Mutation of miR‐133a binding sites in the 3′‐UTR of Col1A1 mRNA abolished miR‐133a‐mediated repression of reporter gene activity, showing that Col1A1 is a real target of miR‐133a. In vivo, Ang II caused an increase in systolic blood pressure (P < 0.0001, tail cuff) and myocardial fibrosis in presence of a decrease in miR‐133a (P < 0.01) and miR‐29b (P < 0.01), and an increase in Col1A1 expression (P < 0.01). These effects were abolished by Ang II administration + irbesartan. These data demonstrate a relationship between miR‐133a and Col1A1, suggesting that myocardial fibrosis occurring in Ang II‐dependent hypertension is regulated by the down‐regulation of miR‐133a and miR‐29b through the modulation of Col1A1 expression. J. Cell. Physiol. 227: 850–856, 2012. © 2011 Wiley Periodicals, Inc.
Angiotensin‐(1–7) decreases LPS‐induced inflammatory response in macrophages
Authors: Souza Laura L. , Costa‐Neto Claudio M. 
Published: July 2011

AbstractIt has been previously shown that besides its classical role in blood pressure control the renin–angiotensin system, mainly by action of angiotensin II on the AT1 receptor, exerts pro‐inflammatory effects such as by inducing the production of cytokines. More recently, alternative pathways to this system were described, such as binding of angiotensin‐(1–7) to receptor Mas, which was shown to counteract some of the effects evoked by activation of the angiotensin II–AT1 receptor axis. Here, by means of different molecular approaches we investigated the role of angiotensin‐(1–7) in modulating inflammatory responses triggered in mouse peritoneal macrophages. Our results show that receptor Mas transcripts were up‐regulated by eightfold in LPS‐induced macrophages. Interestingly, macrophage stimulation with angiotensin‐(1–7), following to LPS exposure, evoked an attenuation in expression of TNF‐α and IL‐6 pro‐inflammatory cytokines; where this event was abolished when the receptor Mas selective antagonist A779 was also included. We then used heterologous expression of the receptor Mas in HEK293T cells to search for the molecular mechanisms underlying the angiotensin‐(1–7)‐mediated anti‐inflammatory responses by a kinase array; what suggested the involvement of the Src kinase family. In LPS‐induced macrophages, this finding was corroborated using the PP2 compound, a specific Src kinase inhibitor; and also by Western blotting when we observed that Ang‐(1–7) attenuated the phosphorylation levels of Lyn, a member of the Src kinase family. Our findings bring evidence for an anti‐inflammatory role for angiotensin‐(1–7) at the cellular level, as well as show that its probable mechanism of action includes the modulation of Src kinases activities. J. Cell. Physiol. 227: 2117–2122, 2012. © 2011 Wiley Periodicals, Inc.
Characterization of HCN and cardiac function in a colonial ascidian
Authors: Hellbach Annette , Tiozzo Stefano , Ohn Jungho , Liebling Michael , De Tomaso Anthony W. 
Published: July 2011

AbstractHyperpolarization‐activated, cyclic nucleotide‐gated (HCN) channels generate the rhythmic beating of mammalian hearts. We identified an HCN homolog in the colonial ascidian Botryllus schlosseri, a nonvertebrate chordate which possesses a tubular heart that beats bidirectionally. Contractions initiate at one end of the heart and travel across the length of the organ, and these periodically reverse, suggesting the presence of two pacemakers, one on each side. We find that HCN expression is highly enriched in cells scattered throughout the myocardium. We functionally analyzed the role of HCN channels in heartbeat using the antagonists Cilobradine and Zatebradine, which decreased the heartbeat in a reversible manner. We also assessed the role of β‐adrenoreceptors in regulating HCN function using the antagonist Metoprolol, which lowered heartbeat rate (HR), as well as the agonist Isoproterenol, which did not alter HR, but caused simultaneous beating, analogous to a fibrillation. Measurements of direction and velocity of blood flow by making use of a novel system to study heart function in model systems amenable to live imaging revealed a significant correlation between heartbeat arrhythmia and drug treatment, similar to that observed with the same drugs in vertebrates. These results suggest that the heart pacemaker in tunicates may be homologous to that in their vertebrate counterparts in both development and function. J. Exp. Zool. 315:476–486, 2011. © 2011 Wiley‐Liss, Inc.