bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tropique de l'intime
Authors: Portets Noëlle 
Published: August 2010

Résumé L’intime traduit ce qu’il y a de plus intérieur. Pourtant, l’intime ne prend consistance que parce qu’il vient d’abord de l’hors de soi : l’intime nous vient de l’adresse des autres ; c’est parce que l’on est interpellé, par la loi, par les autres, que chaque existence prend consistance. Où l’on s’intéressera à comprendre en quoi l’intime est un concept à la fois politique et relationnel. Les travailleurs sociaux ne peuvent alors qu’être attentifs aux enjeux d’effectuation de l’intime, mais aussi aux menaces de précari-sation de soi. Ils ne peuvent être aujourd’hui que préoccupés par ses conditions d’effectuation possible dans un temps politique de « privation» de l’intime.
TLR9 Contributes to the Recognition of EBV by Primary Monocytes and Plasmacytoid Dendritic Cells
Authors: Fiola Stéphanie , Gosselin David , Takada Kenzo , Gosselin Jean 
Published: August 2010

Abstract
TLR9 plays an important role in innate defense against viruses by the detection of CpG motifs of foreign DNA within intracellular compartments. In this study, we evaluated the ability of EBV to promote monocyte and plasmacytoid dendritic cell (pDC) activation and cytokine release through TLR9 activation. We demonstrated that treatment of primary monocytes with EBV and with purified EBV DNA induced the release of IL-8 through TLR9. Activation of TLR9 by viral DNA requires endosomal maturation because pretreatment of monocytes with chloroquine strongly reduced IL-8 secretion. However, pretreatment of monocytes with siRNA directed against TLR2, with inhibitory ODN (iODN) or with a combination of both inhibitors strongly reduced the secretion of IL-8, providing evidence of a dual action of TLR2 and TLR9 in EBV recognition by monocytes. In contrast, production of MCP-1 and IL-10 in EBV-treated monocytes was mainly regulated through TLR2. Although EBV does not establish infection in pDCs, challenge with either live EBV particles or isolated EBV DNA was found to induce the release of IFN-α through TLR9, as supported by blockage of TLR9 activity with iODN or chloroquine. The role of TLR9 in the recognition of EBV by pDCs appears to be dominant, as confirmed by the marked inhibitory effect of iODN observed on the synthesis of IFN-α, IL-6, and IL-8 by pDCs. These results demonstrate that recognition of EBV by TLR9 is differently orchestrated in primary monocytes and pDCs to optimize viral recognition and antiviral response.
Ethylenecarbodiimide-Treated Splenocytes Carrying Male CD4 Epitopes Confer Histocompatability Y Chromosome Antigen Transplant Protection by Inhibiting CD154 Upregulation
Authors: Martin Aaron J. , McCarthy Derrick , Waltenbaugh Carl , Goings Gwen , Luo Xunrong , Miller Stephen D. 
Published: August 2010

Abstract
In humans and certain strains of laboratory mice, male tissue is recognized as nonself and destroyed by the female immune system via recognition of histocompatibility Y chromosome Ag (Hya). Male tissue destruction is thought to be accomplished by CTLs in a helper-dependent manner. We show that graft protection induced with the immunodominant Hya-encoded CD4 epitope (Dby) attached to female splenic leukocytes (Dby-SPs) with the chemical cross-linker ethylenecarbodiimide significantly, and often indefinitely, prolongs the survival of male skin graft transplants in an Ag-specific manner. In contrast, treatments with the Hya CD8 epitopes (Uty-/Smcy-SPs) failed to prolong graft survival. Dby-SP–tolerized CD4+ T cells fail to proliferate, secrete IFN-γ, or effectively prime a CD8 response in recipients of male grafts. Ag-coupled splenocyte treatment is associated with defective CD40–CD40L interactions as demonstrated by the observation that CD4 cells from treated animals exhibit a defect in CD40L upregulation following in vitro Ag challenge. Furthermore, treatment with an agonistic anti-CD40 Ab at the time of transplantation abrogates protection from graft rejection. Interestingly, anti-CD40 treatment completely restores the function of Dby-specific CD4 cells but not Uty- or Smcy-specific CD8 cells.
TGF-β Is Required To Maintain the Pool of Immature Langerhans Cells in the Epidermis
Authors: Kel Junda M. , Girard-Madoux Mathilde J. H. , Reizis Boris , Clausen Björn E. 
Published: August 2010

Abstract
The pivotal role of TGF-β in Langerhans cell (LC) development has been previously established in TGF-β–deficient mice, which lack epidermal LCs. As to whether TGF-β also governs LC homeostasis and function remains elusive. To assess the role of TGF-β–mediated control of cutaneous dendritic cells (DCs) in vivo, we generated mice with a conditional knockout of the TGF-β receptor 1 (TβR1) under a DC-specific promoter (DC-TβR1del mice). While initial LC seeding occurred in DC-TβR1del mice, the cells disappeared from the epidermis during the first week of life. TβR1-deficient LCs demonstrated spontaneous maturation and gained migratory potential based on increased surface expression of MHC class II, costimulatory molecules, and CCR7 and downregulation of E-cadherin. In parallel to their early loss from the epidermis, migrating LCs were reduced in the dermis and skin-draining lymph nodes of adult DC-TβR1del mice, whereas the number of Langerin+ dermal DCs was similar to wild-type. In the absence of LCs, low-dose contact hypersensitivity in DC-TβR1del mice was significantly diminished. In contrast, ear swelling was restored to wild-type levels when a higher hapten dose was applied to efficiently target TβR1-deficient dermal DCs. In conclusion, TGF-β inhibits in vivo LC maturation and migratory phenotype, identifying TGF-β as a critical factor controlling LC homeostasis in the steady state.
A Generalized Poisson Transform of an Lp-Function over the Shilov Boundary of the
n-Dimensional Lie Ball
Authors: El Wassouli Fouzia 
Published: August 2010

AbstractLet 𝒟 be the n-dimensional Lie ball and let
𝔅(S) be the space of hyperfunctions on the Shilov
boundary S of 𝒟. The aim of this paper is to give a
necessary and sufficient condition on the generalized Poisson transform
Pl，λf of an element f in the space
𝔅(S) for f to be in
Lp(S), 1 < p < 1. Namely, if
F is the Poisson transform of some f ∈
𝔅(S) (i.e., F = Pl，λf ), then for any l ∈ ℤ and ， ∈
C such that , we show
that f ∈ Lp(S) if and only if f satisfies
the growth condition
Π‐Bridge Modulations in D–π–A Conjugated Microporous Polymers to Facilitate Charge Separation and Transfer Kinetics for Efficient Photocatalysis
Authors: Li Chunlei , Xu Hetao , Xiong Hao , Xia Shuling , Peng Xu , Xu Fei , Chen Xiong 
Published: May 2024

AbstractThe burgeoning field of conjugated microporous polymers (CMPs) has generated widespread interest due to their potential as photocatalysts for hydrogen production from water. Nevertheless, their photocatalytic performance is sometimes hindered by inadequate charge separation and transfer, coupled with rapid charge recombination. Herein, a strategy to enhance photocatalytic performance via the customization of π‐bridges through the modulation of heteroatoms in a series of donor‐π‐acceptor (D‐π‐A) CMPs is proposed. This affords optimized energy levels and improved charge separation and transfer, thus boosting photocatalytic efficiency. Among various heteroatom substitutions, S‐doped CMP (10 mg) demonstrates the highest photocatalytic hydrogen evolution rate of 203 µmol h−1 (AQY450nm = 7.4%) under visible light irradiation. Subsequent experimental analysis reveals its superior photocatalytic performance can be largely related to its minimized exciton binding energy, facilitated charge transfer efficiency, and impeded charge recombination among these heteroatom‐doped D‐π‐A CMPs. This research paves the way for the rational design and modification of organic semiconductors for advanced solar‐driven photocatalysis by promoting charge separation and transfer.
Ultrasound‐Responsive Aligned Piezoelectric Nanofibers Derived Hydrogel Conduits for Peripheral Nerve Regeneration
Authors: Xu Dongyu , Fu Siqi , Zhang Hui , Lu Weicheng , Xie Jingdun , Li Jilai , Wang Huan , Zhao Yuanjin , Chai Renjie 
Published: May 2024

AbstractNerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes are limited by the lack of controllable drug delivery and available physicochemical cues. Herein, novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)‐triggered electrical stimulation (ES) and controllable drug release for repairing peripheral nerve injury are proposed. The inner layer of the NGCs is the barium titanate piezoelectric nanoparticles (BTNPs)‐doped polyvinylidene fluoride‐trifluoroethylene [BTNPs/P(VDF‐TrFE)] electrospinning nanofibers with improved piezoelectricity and aligned orientation. The outer side of the NGCs is the thermoresponsive poly(N‐isopropylacrylamide) hybrid hydrogel with bioactive drug encapsulation. Such NGCs can not only induce neuronal‐oriented extension and promote neurite outgrowth with US‐triggered wireless ES, but also realize the controllable nerve growth factor release with the hydrogel shrinkage under US‐triggered heating. Thus, the NGC can positively accelerate the functional recovery and nerve axonal regeneration of rat models with long sciatic nerve defects. It is believed that the proposed US‐responsive aligned piezoelectric nanofibers derived hydrogel NGCs will find important applications in clinic neural tissue engineering.
Reducing Peptidoglycan Crosslinking by Chemical Modulator Reverts β‐lactam Resistance in Methicillin‐Resistant Staphylococcus aureus
Authors: Kim Ji‐Hoon , Lee Yunmi , Kim Inseo , Chang JuOae , Hong Subin , Lee Na Kyung , Shum David , Baek Seongeun , Kim Wooseong , Jang Soojin , Lee Wonsik 
Published: May 2024

AbstractSmall molecule can be utilized to restore the effectiveness of existing major classes of antibiotics against antibiotic‐resistant bacteria. In this study, it is demonstrated that celastrol, a natural compound, can modify the bacterial cell wall and subsequently render bacteria more suceptible to β‐lactam antibiotics. It is shown that celastrol leads to incomplete cell wall crosslinking by modulating levels of c‐di‐AMP, a secondary messenger, in methicillin‐resistant Staphylococcus aureus (MRSA). This mechanism enables celastrol to act as a potentiator, effectively rendering MRSA susceptible to a range of penicillins and cephalosporins. Restoration of in vivo susceptibility of MRSA to methicillin is also demonstrated using a sepsis animal model by co‐administering methicillin along with celastrol at a much lower amount than that of methicillin. The results suggest a novel approach for developing potentiators for major classes of antibiotics by exploring molecules that re‐program metabolic pathways to reverse β‐lactam‐resistant strains to susceptible strains.
Clearfield upland rice intercropped with Urochloa ruziziensis for grain, increased revenue and environmental preservation
Authors: de Sousa Santos Fenelon Lourenço , Nascente Adriano Stephan , Lacerda Mabio Chisley , Calil Francine Neves 
Published: May 2024

AbstractIntercropping perennial forage grasses into cereal crops is an alternative to recover degraded pastures. However, the intercrop of forage grasses, such as Urochloa ruziziensis (R. Germ. and C. M. Evard) Crins (Congo grass), can lead to losses in cereal yield. Therefore, it is necessary to develop management strategies that allow forage grass establishment without major losses in cereal yield in intercropping. The objective was to study the agronomic and economic impacts of intercropping U. ruziziensis into a Clearfield upland rice (Oryza sativa L.) cultivar in the state of Goiás, Brazil, in two growing seasons. Treatments included forage grass seeds sowing method (broadcast or incorporation to the soil) and sowing times (at rice sowing, 20 days after emergence [DAE], and 45 DAE of rice). Also, imazapyr + imazapic herbicide was applied to restrict the competitive effect on rice yield. Monocropping control plots were also evaluated. Grain yield was measured on rice. Forage grass dry matter yield was measured at 30, 60, and 90 days after harvesting (DAH) of rice. Crude protein content was analyzed at 90 DAH. Profitability was calculated for each cropping system relative to rice monocropping. Intercropping of rice and U. ruziziensis sowed at 45 DAE provided the highest grain yield relative to other assessed intercropping treatments as well as rice monocropping. Concurrent sowing of rice and incorporated U. ruziziensis seeding provided the greatest economic return. This reformed cropping system improved land and pasture output, which can reduce the pressure to convert more land to agricultural use.
FI‐Net: Rethinking Feature Interactions for Medical Image Segmentation
Authors: Ding Yuhan , Liu Jinhui , He Yunbo , Huang Jinliang , Liang Haisu , Yi Zhenglin , Wang Yongjie 
Published: May 2024

To solve the problems of existing hybrid networks based on convolutional neural networks (CNN) and Transformers, we propose a new encoder–decoder network FI‐Net based on CNN‐Transformer for medical image segmentation. In the encoder part, a dual‐stream encoder is used to capture local details and long‐range dependencies. Moreover, the attentional feature fusion module is used to perform interactive feature fusion of dual‐branch features, maximizing the retention of local details and global semantic information in medical images. At the same time, the multi‐scale feature aggregation module is used to aggregate local information and capture multi‐scale context to mine more semantic details. The multi‐level feature bridging module is used in skip connections to bridge multi‐level features and mask information to assist multi‐scale feature interaction. Experimental results on seven public medical image datasets fully demonstrate the effectiveness and advancement of our method. In future work, we plan to extend FI‐Net to support 3D medical image segmentation tasks and combine self‐supervised learning and knowledge distillation to alleviate the overfitting problem of limited data training.
Three‐dimensional telomere profiling predicts risk of progression in smoldering multiple myeloma
Authors: Kumar Shaji , Rajkumar S. Vincent , Jevremovic Dragan , Kyle Robert A. , Shifrin Yulia , Nguyen Michelle , Husain Zahabiya , Alikhah Asieh , Jafari Anita , Mai Sabine , Anderson Kenneth , Louis Sherif 
Published: May 2024

AbstractSmoldering multiple myeloma (SMM) is a precursor stage that precedes multiple myeloma (MM). SMM is heterogenous with nearly 40% of patients progressing to MM in the first 5 years. The high rate of progression of SMM patients highlights the need for early intervention, which underscores the importance of identifying SMM patients with the highest risk of progression. Several risk stratification models showed utility in identifying high‐risk SMM patients; however, these systems showed limited sensitivity. To date, identifying high‐risk SMM patients remains an important clinical need. In this study, we present the 3‐dimensional telomere profiling as a structural biomarker capable of stratifying SMM patients as a function of genomic instability. Quantifying telomere dysfunction using the TeloView technology showed utility in risk stratification of cancer patients, particularly hematological malignancies. In this study, we analyzed 168 SMM patients. We report an AUC in ROC analysis of 0.8 using a subset of the patients as a training dataset. We then conducted a blind validation on a different cohort and demonstrated a positive predictive value of 85% and negative predictive value of 73%, with sensitivity and specificity of 83% and 76%, respectively. We examined the correlation between the TeloView prediction and the 20‐2‐20 scoring system, and cytogenetic abnormalities. We report a correlation of 53% with the 20‐2‐20 scores and over 60% correlation with cytogenetic abnormalities. The result of this study presents the telomere profiling as an effective biomarker able to stratify SMM patients to their respective risk groups with high sensitivity and specificity.
Changes needed to reduce risk of musculoskeletal disorders
Authors: Macdonald Wendy A. , Oakman Jodi 
Published: May 2024

AbstractMusculoskeletal disorders (MSDs) are the main contributor to disability levels, which are rising as populations age. Workplace hazard exposures are a major source of this problem, and current workplace risk management practices require substantial changes to tackle it more effectively. Most importantly, the current focus of risk management on “manual handling” tasks must broaden to encompass the whole job. This is necessary because a wide range of psychosocial hazards, most of which operate across the whole job rather than particular tasks, are significant contributors to risk. To ensure that risk‐control actions are effective, a recurring risk management cycle that includes worker participation and addresses risk from both biomechanical and psychosocial hazards will be essential. Legislation that mandates workplace management of psychosocial hazards would be helpful. Amendment by regulatory bodies of MSD‐related guidance and codes of practice so that they reflect current research evidence would also be helpful in communicating the need for change to workplace stakeholders.
Neuropsychological functioning of adults with PTEN hamartoma tumor syndrome
Authors: Oldenboom Carmen , Drissen Meggie M. C. M. , van Dongen Linde C. M. , Kleefstra Tjitske , Prins Judith B. , Egger Jos I. M. , Hoogerbrugge Nicoline 
Published: May 2024

AbstractPTEN hamartoma tumor syndrome (PHTS) might be associated with a distinct cognitive and psychological profile. However, previous studies are limited, predominantly based on small and pediatric cohorts, likely affected by selection bias, and show a broad range of findings. We aimed to characterize the neuropsychological functioning of adults with PHTS. A total of 40 participants, with intellectual disability as exclusion criterium, completed an extensive clinical neuropsychological assessment including cognitive tasks, questionnaires, and a clinical diagnostic interview. The cognitive tasks and questionnaire data were categorized as below and above average based on 1.5 SD. About 80% of participants showed an average level of intelligence. In addition, 30% and 24% of participants scored below average on immediate memory recall and speed of information processing, respectively. Furthermore, about 25% reported above average scores on the majority of the questionnaires, indicating psychological distress, signs of alexithymia, and cognitive complaints. Personality of participants was characterized by inflexibility, social withdrawal, and difficulties in recognizing and describing their own emotions. Adults with PHTS demonstrate a heterogeneous yet distinct neuropsychological profile that is characterized by slower information processing, psychological problems, and specific personality traits. These findings provide directions on how to optimize the care and daily lives of adults with PHTS.
Pathogenicity and transcriptomic profiling reveals immunology molecular hallmarks after CA10 virus infection
Authors: Peng Wanjun , Wu Jing , Zhao Binbin , Zhang Lihong , Chen Xin , Wei Xiaohui , Rong Na , Han Yunlin , Liu Jiangning 
Published: May 2024

AbstractBackgroundHand, foot and mouth disease (HFMD) is a common infectious disease caused by viral infection by a variety of enteroviruses, with coxsackievirus A 10 (CA10) having become more prevalent in recent years.MethodsIn this study, models of CA10 infection were established in 7‐day‐old Institute of Cancer Research (ICR) mice by intraperitoneal injection to analyze the pathogenicity of the virus. RNA sequencing analysis was used to screen the differentially expressed genes (DEGs) after CA10 infection. Coxsackievirus A 16 (CA16) and enterovirus 71 (EV71) infections were also compared with CA10.ResultsAfter CA10 virus infection, the mice showed paralysis of the hind limbs at 3 days post infection and weight loss at 5 days post infection. We observed viral replication in various tissues and severe inflammatory cell infiltration in skeletal muscle. The RNA‐sequencing analysis showed that the DEGs in blood, muscle, thymus and spleen showed heterogeneity after CA10 infection and the most up‐regulated DEGs in muscle were enriched in immune‐related pathways. Compared with CA16 and EV71 infection, CA10 may have an inhibitory effect on T helper (Th) cell differentiation and cell growth. Additionally, the common DEGs in the three viruses were most enriched in the immune system response, including the Toll‐like receptor pathway and the nucleotide‐binding and oligomerization domain (NOD)‐like pathway.ConclusionsOur findings revealed a group of genes that coordinate in response to CA10 infection, which increases our understanding of the pathological mechanism of HFMD.
Vollständig anorganische sp‐Kettenliganden: Isoelektronische B/N‐Analoga von E. O. Fischers Alkinylcarbinen
Authors: Walther Luis , Radacki Krzysztof , Dewhurst Rian D. , Bertermann Rüdiger , Finze Maik , Braunschweig Holger 
Published: May 2024

AbstractBorylierung eines wolframgebundenen N2‐Liganden und anschließende Halogenidabstraktion ermöglichen den Zugang zu einem kationischen Komplex mit einem bisher beispiellosen linearen NNBR‐Liganden. Dieser Komplex geht [3+2] Cycloadditionen mit Aziden ein und eine unerwartete Kettenverlängerungsreaktion mit einem Iminoboran, was zu einem Komplex mit einer fünfatomigen B/N‐Kette führt. Diese beiden [NNBR]‐haltigen Komplexe, anorganische Analoga von E. O. Fischers Alkinylcarbinen, sind sehr seltene Beispiele für Moleküle, die rein anorganische Ketten von sp‐hybridisierten Atomen enthalten.
Effiziente Cu‐katalysierte Tandem‐Klicksynthese von mehrfach zuckermodifizierten Oligonukleotiden
Authors: Tölke Annika J. , Gaisbauer Julia F. , Gärtner Yasmin V. , Steigenberger Barbara , Holovan Anna , Streshnev Filip , Schneider Sabine , Müller Markus , Carell Thomas 
Published: May 2024

AbstractNukleinsäuren in Form von siRNA, Antisense‐Oligonukleotiden oder mRNA werden derzeit als neue vielversprechende Modalitäten in der pharmazeutischen Industrie erforscht. Insbesondere der Erfolg von mRNA‐Impfstoffen gegen SARS‐CoV‐2 sowie die erfolgreiche Entwicklung der ersten zuckermodifizierten siRNA‐Therapeutika haben das Feld beflügelt. Die Entwicklung von Nukleinsäuretherapeutika erfordert eine effiziente Chemie, um Oligonukleotide mit chemischen Strukturen zu verknüpfen, die die Stabilität verbessern, die Aufnahme in die Zellen fördern oder eine spezifische Adressierung ermöglichen. Für die derzeit verwendeten siRNA‐Therapeutika hat sich die Modifizierung des 3′‐Endes der Oligonukleotide mit Triple‐N‐Acetylgalactosamin (GalNAc)3 als wichtig erwiesen. Diese Modifikation wird derzeit durch eine umständliche, mehrstufige Synthese und anschließende Beladung auf das Trägermaterial erreicht. Hier berichten wir über die Entwicklung eines bifunktionellen, klickreaktiven Linkers, der die Modifizierung von Oligonukleotiden in einer Tandem‐Klickreaktion mit multiplen Zuckern, unabhängig von der Position innerhalb des Oligonukleotids, mit bemerkenswerter Effizienz und in einer Ein‐Topf Reaktion ermöglicht.