bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a probabilistic risk model for pharmaceuticals in the environment under population and wastewater treatment scenarios
Authors: Welch Samuel A. , Grung Merete , Madsen Anders L. , Jannicke Moe S. 
Published: May 2024

Abstract
Preparing for future environmental pressures requires projections of how relevant risks will change over time. Current regulatory models of environmental risk assessment (ERA) of pollutants such as pharmaceuticals could be improved by considering the influence of global change factors (e.g., population growth) and by presenting uncertainty more transparently. In this article, we present the development of a prototype object-oriented Bayesian network (BN) for the prediction of environmental risk for six high-priority pharmaceuticals across 36 scenarios: current and three future population scenarios, combined with infrastructure scenarios, in three Norwegian counties. We compare the risk, characterized by probability distributions of risk quotients (RQs), across scenarios and pharmaceuticals. Our results suggest that RQs would be greatest in rural counties, due to the lower development of current wastewater treatment facilities, but that these areas consequently have the most potential for risk mitigation. This pattern intensifies under higher population growth scenarios. With this prototype, we developed a hierarchical probabilistic model and demonstrated its potential in forecasting the environmental risk of chemical stressors under plausible demographic and management scenarios, contributing to the further development of BNs for ERA. Integr Environ Assess Manag 2024;20:1715–1735. © 2024 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).
Key Points
We constructed a prototype object-oriented Bayesian network to predict the environmental risks of six key pharmaceuticals in Norwegian surface waters under 36 plausible future scenarios. Object-oriented design paradigms allowed efficient modular construction of a pharmaceutical consumption-to-pollution probabilistic environmental risk assessment (ERA) network. Our initial predictions indicated that, of the pharmaceuticals considered, ethinylestradiol presented by far the highest risk quotients, followed by ibuprofen; risk was greatest in rural areas, without effective wastewater treatment, and under high population growth scenarios. Our prototype sets the stage for Bayesian network-based ERA of pharmaceuticals; however, there are several technical limitations that still hold the approach back.
Cover Image
Authors: Zhong Chengquan , Zhang Jingzi , Wang Yuelin , Long Yanwu , Zhu Pengzhou , Liu Jiakai , Hu Kailong , Chen Junjie , Lin Xi 
Published: May 2024

The image highlights our artificial intelligence framework, named Supercon‐Diffusion, for the inverse design of high‐temperature superconductors.
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Instant clot forming and antibacterial wound dressings: Achieving hemostasis in trauma injuries with S‐nitroso‐N‐acetylpenicillamine—tranexamic acid—propolis formulation
Authors: Nguyen Dieu Thao , Pant Jitendra , Sapkota Aasma , Goudie Marcus James , Singha Priyadarshini , Brisbois Elizabeth J , Handa Hitesh 
Published: May 2024

AbstractWound infection and excessive blood loss are the two major challenges associated with trauma injuries that account for 10% of annual deaths in the United States. Nitric oxide (NO) is a gasotransmitter cell signaling molecule that plays a crucial role in the natural wound healing process due to its antibacterial, anti‐inflammatory, cell proliferation, and tissue remodeling abilities. Tranexamic acid (TXA), a prothrombotic agent, has been used topically and systemically to control blood loss in reported cases of epistaxis and combat‐related trauma injuries. Its properties could be incorporated in wound dressings to induce immediate clot formation, which is a key factor in controlling excessive blood loss. This study introduces a novel, instant clot‐forming NO‐releasing dressing, and fabricated using a strategic bi‐layer configuration. The layer adjacent to the wound was designed with TXA suspended on a resinous bed of propolis, which is a natural bioadhesive possessing antibacterial and anti‐inflammatory properties. The base layer, located furthest away from the wound, has an NO donor, S‐nitroso‐N‐acetylpenicillamine (SNAP), embedded in a polymeric bed of Carbosil®, a copolymer of polycarbonate urethane and silicone. Propolis was integrated with a uniform layer of TXA in variable concentrations: 2.5, 5.0, and 7.5 vol % of propolis. This design of the TXA–SNAP–propolis (T‐SP) wound dressing allows TXA to form a more stable clot by preventing the lysis of fibrin. The lactate dehydrogenase‐based platelet adhesion assay showed an increase in fibrin activation with 7.5% T‐SP as compared with control within the first 15 min of its application. A scanning electron microscope (SEM) confirmed the presence of a dense fibrin network stabilizing the clot for fabricated dressing. The antibacterial activity of NO and propolis resulted in a 98.9 ± 1% and 99.4 ± 1% reduction in the colony‐forming unit of Staphylococcus aureus and multidrug‐resistant Acinetobacter baumannii, respectively, which puts forward the fabricated dressing as an emergency first aid for traumatic injuries, preventing excessive blood loss and soil‐borne infections.
Unveiling myricetin's pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling
Authors: Goyal Ahsas , Sikarwar Om , Verma Aanchal , Solanki Kunal , Agrawal Neetu , Dubey Nandini , Yadav Harlokesh Narayan 
Published: May 2024

AbstractMyricetin can be found in the traditional Chinese medicinal plant, Myrica rubra. Myricetin is a flavonoid that is present in many vegetables, fruits, and plants and is considered to have strong antioxidant properties as well as a wide range of therapeutic applications. Growing interest has been piqued by its classification as a polyphenolic molecule because of its potential therapeutic benefits in both the prevention and management of numerous medical conditions. To clarify myricetin's traditional medical uses, modern research has investigated various pharmacological effects such as antioxidant, anticancer, anti‐inflammation, antiviral, antidiabetic, immunomodulation, and antineurodegenerative effects. Myricetin shows promise as a nutritional flavonol that could be beneficial in the prevention and mitigation of prevalent health conditions like diabetes, cognitive decline, and various types of cancer in humans. The findings included in this study indicate that myricetin has a great deal of promise for application in the formulation of medicinal products and nutritional supplements since it affects several enzyme activities and alters inflammatory markers. However, comprehensive preclinical studies and research studies are necessary to lay the groundwork for assessing myricetin's possible effectiveness in treating these long‐term ailments. This review summarizes both in vivo and in vitro studies investigating myricetin's possible interactions through the nuclear factor‐E2‐related factor 2 (Nrf2) as well as PI3K (phosphatidylinositol 3‐kinase)/AKT (protein kinase B) signaling pathways in an attempt to clarify the compound's possible clinical applicability across a range of disorders.
Block‐transitive triple systems with sporadic or alternating socle
Authors: Ding Suyun , Zhang Yilin , Zhan Xiaoqin , Chen Guangzu 
Published: May 2024

AbstractThis paper is a contribution to the classification of all pairs , where is a triple system and is a block‐transitive but not flag‐transitive automorphism group of . We prove that if the socle of is a sporadic or alternating group, then one of the following holds:

is a and ;
is a and ;
is a and or ;
is a with and .
The Oberwolfach problem with loving couples
Authors: Rinaldi Gloria 
Published: May 2024

AbstractWe generalize the well‐known Oberwolfach problem posed by Ringel in 1967. We suppose to have couples (here is an even integer) and suppose that they have to be seated for several nights at round tables in such a way that each person seats next to his partner exactly times and next to every other person exactly once. We call this problem the Oberwolfach problem with loving couples. When , the problem coincides with the so‐called spouse‐avoiding variant, which was introduced by Huang, Kotzig, and Rosa in 1979. While if either or equals the number of nights, it corresponds to the spouse‐loving variant or to the Honeymoon variant, which was recently studied by Bolohan et al. and by Lepine and Sajna, respectively. In this paper, for each possible choice of , we construct many classes of solutions to the Oberwolfach problem with loving couples. We also obtain new solutions to the Honeymoon variant.
Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes
Authors: Shao Bryanna , Killion Mason , Oliver Ashton , Vang Chia , Zeleke Faben , Neikirk Kit , Vue Zer , Garza‐Lopez Edgar , Shao Jian‐qiang , Mungai Margaret , Lam Jacob , Williams Qiana , Altamura Christopher T. , Whiteside Aaron , Kabugi Kinuthia , McKenzie Jessica , Ezedimma Maria , Le Han , Koh Alice , Scudese Estevão , Vang Larry , Marshall Andrea G. , Crabtree Amber , Tanghal Janelle I. , Stephens Dominique , Koh Ho‐Jin , Jenkins Brenita C. , Murray Sandra A. , Cooper Anthonya T. , Williams Clintoria , Damo Steven M. , McReynolds Melanie R. , Gaddy Jennifer A. , Wanjalla Celestine N. , Beasley Heather K. , Hinton Antentor 
Published: May 2024

AbstractThe sorting and assembly machinery (SAM) Complex is responsible for assembling β‐barrel proteins in the mitochondrial membrane. Comprising three subunits, Sam35, Sam37, and Sam50, the SAM complex connects the inner and outer mitochondrial membranes by interacting with the mitochondrial contact site and cristae organizing system complex. Sam50, in particular, stabilizes the mitochondrial intermembrane space bridging (MIB) complex, which is crucial for protein transport, respiratory chain complex assembly, and regulation of cristae integrity. While the role of Sam50 in mitochondrial structure and metabolism in skeletal muscle remains unclear, this study aims to investigate its impact. Serial block‐face‐scanning electron microscopy and computer‐assisted 3D renderings were employed to compare mitochondrial structure and networking in Sam50‐deficient myotubes from mice and humans with wild‐type (WT) myotubes. Furthermore, autophagosome 3D structure was assessed in human myotubes. Mitochondrial metabolic phenotypes were assessed using Gas Chromatography‐Mass Spectrometry‐based metabolomics to explore differential changes in WT and Sam50‐deficient myotubes. The results revealed increased mitochondrial fragmentation and autophagosome formation in Sam50‐deficient myotubes compared to controls. Metabolomic analysis indicated elevated metabolism of propanoate and several amino acids, including ß‐Alanine, phenylalanine, and tyrosine, along with increased amino acid and fatty acid metabolism in Sam50‐deficient myotubes. Furthermore, impairment of oxidative capacity was observed upon Sam50 ablation in both murine and human myotubes, as measured with the XF24 Seahorse Analyzer. Collectively, these findings support the critical role of Sam50 in establishing and maintaining mitochondrial integrity, cristae structure, and mitochondrial metabolism. By elucidating the impact of Sam50‐deficiency, this study enhances our understanding of mitochondrial function in skeletal muscle.
Venous thromboembolism performance measurement in the United States: An evolving landscape with many stakeholders
Authors: Braun Barbara I. , Kolbusz Karen M. , Bozikis Michele R. , Schmaltz Stephen P. , Abe Karon , Reyes Nimia L. , Dardis Michelle N. 
Published: May 2024

AbstractVenous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is a life‐threatening, costly, and common preventable complication associated with hospitalization. Although VTE prevention strategies such as risk assessment and prophylaxis are available, they are not applied uniformly or systematically across US hospitals and healthcare systems. Hospital‐level performance measurement has been used nationally to promote standardized approaches for VTE prevention and incentivize the adoption of guideline‐based care management. Though most measures reflect care processes rather than outcomes, certain domains including diagnosis, treatment, and continuity of care remain unmeasured. In this article, we describe the development of VTE prevention measures from various stakeholders, measure strengths and limitations, publicly reported rates, the impact of technology and health policy on measure use, and perspectives on future options for surveillance and performance monitoring.
Improving Microstructural Estimation in Time‐Dependent Diffusion MRI With a Bayesian Method
Authors: Liu Kuiyuan , Lin Zixuan , Zheng Tianshu , Ba Ruicheng , Zhang Zelin , Li Haotian , Zhang Hongxi , Tal Assaf , Wu Dan 
Published: May 2024

BackgroundAccurately fitting diffusion‐time‐dependent diffusion MRI (td‐dMRI) models poses challenges due to complex and nonlinear formulas, signal noise, and limited clinical data acquisition.PurposeIntroduce a Bayesian methodology to refine microstructural fitting within the IMPULSED (Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion) model and optimize the prior distribution within the Bayesian framework.Study TypeRetrospective.PopulationInvolving 69 pediatric patients (median age 6 years, interquartile range [IQR] 3–9 years, 61% male) with 41 low‐grade and 28 high‐grade gliomas, of which 76.8% were identified within the brainstem or cerebellum.Field Strength/Sequence3 T, oscillating gradient spin‐echo (OGSE) and pulsed gradient spin‐echo (PGSE).AssessmentThe Bayesian method's performance in fitting cell diameter (), intracellular volume fraction (), and extracellular diffusion coefficient () was compared against the NLLS method, considering simulated and experimental data. The tumor region‐of‐interest (ROI) were manually delineated on the b0 images. The diagnostic performance in distinguishing high‐ and low‐grade gliomas was assessed, and fitting accuracy was validated against H&E‐stained pathology.Statistical TestsT‐test, receiver operating curve (ROC), area under the curve (AUC) and DeLong's test were conducted. Significance considered at P < 0.05.ResultsBayesian methodology manifested increased accuracy with robust estimates in simulation (RMSE decreased by 29.6%, 40.9%, 13.6%, and STD decreased by 29.2%, 43.5%, and 24.0%, respectively for , , and compared to NLLS), indicating fewer outliers and reduced error. Diagnostic performance for tumor grade was similar in both methods, however, Bayesian method generated smoother microstructural maps (outliers ratio decreased by 45.3% ± 19.4%) and a marginal enhancement in correlation with H&E staining result (r = 0.721 for compared to r = 0.698 using NLLS, P = 0.5764).Data ConclusionThe proposed Bayesian method substantially enhances the accuracy and robustness of IMPULSED model estimation, suggesting its potential clinical utility in characterizing cellular microstructure.Evidence Level3Technical EfficacyStage 1
Empowering or burdening? The short‐term benefits and costs of upward networking at work
Authors: Wang Song , Luan Kun , Qin Xin 
Published: May 2024

SummaryResearch on social networking primarily focuses on the long‐term benefits of upward networking on career success. However, how it influences employees in the short term is largely overlooked. Integrating conservation of resources theory and self‐control strength model, we developed a moderated dual‐pathway model that simultaneously examines the immediate benefit and cost of upward networking and investigates how trait self‐control moderates the dual‐pathway mechanism. Based on two experiments and a time‐lagged experience sampling study, we examined the moderated effects of trait self‐control, as well as the conditionally indirect relationship between upward networking and work engagement through the resource gain of perceived impact at work and the resource loss of ego depletion. We found that, on the one hand, for employees high in trait self‐control, engaging in upward networking is likely to be related to perceived impact at work and indirectly affects work engagement. On the other hand, for employees with low trait self‐control, engaging in upward networking is likely to increase ego depletion and indirectly affects work engagement. Overall, our findings contribute to theories of social networking and self‐control and specifically highlight the complexity of upward networking, which both empowers and burdens employees in terms of immediate work outcomes.
Enhanced polysaccharide production through quorum sensing system in Cordyceps militaris
Authors: Qiao Huang , Chen Jianshu , Yang Shengli 
Published: May 2024

AbstractThis study aimed to enhance extracellular polysaccharide (EPS) production in Cordyceps militaris by constructing a quorum sensing (QS) system to regulate the expression of biosynthetic enzyme genes, including phosphoglucomutase, hexokinase, phosphomannomutase, polysaccharide synthase, and UDP‐glucose 4‐epimerase genes. The study found higher EPS concentrations in seven recombinant strains compared to the wild‐type C. militaris, indicating that the overexpression of key enzyme genes increased EPS production. Among them, the CM‐pgm‐2 strain exhibited the highest EPS production, reaching a concentration of 3.82 ± 0.26 g/L, which was 1.52 times higher than the amount produced by the wild C. militaris strain. Additionally, the regulatory effects of aromatic amino acids on the QS system of the CM‐pgm‐2 strain were investigated. Under the influence of 45 mg/L tryptophan, the EPS production in CM‐pgm‐2 reached 4.75 ± 0.20 g/L, representing a 1.90‐fold increase compared to wild C. militaris strains. This study provided an effective method for the large‐scale production of EPSs in C. militaris, and opened up new avenues for research into fungal QS mechanisms.
Semiautomated electronic medical record based system for monitoring delayed adverse events in pediatric endoscopy and sedation
Authors: Wong Jonathan , Abazi Tea , Thielke Rob , Lerner Diana 
Published: May 2024

AbstractObjectiveTo develop a semiautomated electronic medical record (EMR) system to track pediatric endoscopic procedural adverse event (AE) at a tertiary referral children's hospital.MethodsWe developed an automated EMR based query for postprocedure AEs. Main outcome measurements within 30 days of procedure: return to emergency department, return to surgery, unplanned admissions and admissions with longer than intended stays. Events were graded using a recently described classification system for postendoscopy events and tracked for a 36‐month period, from January 2017 to December 2019.ResultsDevelopment of a semi‐automated system was successful in comprehensive identification of endoscopy and sedation related AE. A total of 193 AEs (2%) were identified in all three categories. Seventy cases (0.7%) were noted to be a direct result of an endoscopic procedure. Of these cases, 31 (44%) were noted to be Grade 3, 5 cases (7%) Grade 4, and no Grade 5 AE occured. Higher rates of AE were observed after therapeutic procedures versus diagnostic (2.6% vs. 0.3%, p = <0.00001). AEs related to sedation occurred in 0.5% of procedures with the majority (84%) reported in patients with American Society of Anesthesia classification of 3 or greater.ConclusionsDiagnostic endoscopy remains a safe procedure and risk of both endoscopy and sedation related AE are low. Therapeutic procedures carry a higher risk but are still overwhelmingly safe. Institutional investment in this EMR based system allowed for sustainability and comprehensive tracking of endoscopy related AE.
Surfactants produced from carbohydrate derivatives: Part 2. A review on the value chain, synthesis, and the potential role of artificial intelligence within the biorefinery concept
Authors: Marquez Ronald , Ortiz Maria S. , Barrios Nelson , Vera Ramon E. , Patiño‐Agudelo Álvaro Javier , Vivas Keren A. , Salas Mariangeles , Zambrano Franklin , Theiner Eric 
Published: May 2024

AbstractThis comprehensive and critical review explores the synthesis and applications of carbohydrate‐based surfactants within the biorefinery concept, focusing on biobased sugar‐head molecules suitable for use across several manufacturing sectors, including cosmetics, pharmaceuticals, household products, detergents, and foods. The main focus relies on sustainable alternatives to conventional surfactants, which could reduce the final manufacturing carbon footprint of several industrial feedstocks and products. A thorough analysis of raw materials, highlighting the significance of feedstock sources, and the current biobased surfactants and rhamnolipid biosurfactants production trends, is presented. Key organic reactions for the production of sorbitan esters, sucrose esters, alkyl polyglycosides, and fatty acid glucamines, such as glycosidation, acylation, and etherification, as well as the production of rhamnolipids through fermentation are described. Given the scarce literature on the characterization of these surfactant types within the hydrophilic–lipophilic deviation (HLD) framework, the surfactant contribution parameter (SCP) in the HLD equation for sugar‐head surfactants is critically assessed. The economic landscape is also discussed, noting the significant growth in the biobased surfactants and biosurfactant market, driven by environmental awareness and regulatory changes, with projections indicating a substantial market increase in the forthcoming years. Finally, the promising potential of generative artificial intelligence (AI) in developing customized surfactant molecules, with optimized properties for targeted applications, is emphasized as a promising avenue for future research.