bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer activity of lactoferrin isolated from caprine colostrum on human cancer cell lines
Authors: KIM YOUNGHOON , KIM MAE JIN , HAN KYOUNG SIK , IMM JEE YOUNG , OH SEJONG , KIM SAE HUN 
Published: May 2009

In the present study, lactoferrin was purified from caprine colostrum and its anticancer effects were investigated on various cancer cell lines, including lung, colon, cervix, stomach and breast cancer cells. The caprine lactoferrin (CLF) was purified by ultrafiltration and sequential chromatography using a CM‐Sephadex C‐50‐120 ion‐exchange column and affinity chromatography on Hi‐TrapTM Heparin HP. The purified CLF exhibited antiproliferative effects on the five tested cancer cell lines in a dose‐dependent manner, with 20–30% survival as compared to the control. Interestingly, the most intense inhibition of cell growth was observed on the ZR‐75‐1 breast cancer cells (IC50 = 27.5 µg/mL). Our findings suggest, for the first time, that purified CLF from caprine colostrum may constitute a novel anticancer agent for the food industry.
Studies on the use of acidified and cultured whey as coagulant in the manufacture of paneer
Authors: DESHMUKH DHANAJI S , ZANJAD PRABHAKAR N , PAWAR VITHAL D , MACHEWAD GIRISH M 
Published: May 2009

Acidified and cultured whey were used as coagulants in the manufacture of paneer at coagulation temperatures of 80 and 90°C. The yield and recovery of fat, total solids and the sensory and textural qualities were studied. It was observed that the yield of paneer decreased with increase in coagulation temperature from 80 to 90°C, and the use of acidified and cultured whey further increased the yield of paneer. The percentage recovery of fat and total solids was not greatly influenced by coagulation temperature. However, recovery of these was optimum in paneer made using cultured whey of Lactobacillus acidophilus and acidified whey at 1%. The Streptococcus lactis‐cultured whey yielded lowest fat and total solids. No significant differences (P > 0.05) were observed in all the sensory attributes of paneer made at 80°C using cultured or acidified whey. At 90°C, the sensory score for body and texture differed significantly (P < 0.05). The use of cultured whey with S. lactis resulted in paneer with a soft and loose body and open texture, and was not found suitable for paneer‐making.
Fermentation characteristics and transit tolerance of Lactobacillus casei Zhang in reconstituted mare milk during storage
Authors: ZHOU QI , WANG JICHENG , GUO ZHUANG , YAN LIYA , ZHANG QING , CHEN WEI , LIU XIAO‐MING , ZHANG HE‐PING 
Published: May 2009

The fermentation characteristics of Lactobacillus casei Zhang in mare milk and transit tolerance during refrigerated storage for 28 days were evaluated. There were no dramatic changes in the viable counts of L. casei Zhang in the fermented mare milk samples during storage at various inoculation levels. L. casei Zhang showed good tolerance to the simulated transit juice and maintained high viability in mare milk (above 108cfu/g) during storage. Our results showed that L. casei Zhang had good probiotic properties, and suggest that mare milk could serve as the vehicle for the delivery of L. casei Zhang.
Behaviour of volatile compounds during the shelf life of yoghurt
Authors: PINTO SANDRA MARIA , CLEMENTE MARIA DAS GRAÇAS , DE ABREU LUIZ RONALDO 
Published: May 2009

The production of acetaldehyde, diacetyl and ethanol was evaluated in whole plain yoghurts manufactured with commercial starter cultures, yoghurt acquired in a local market, and milk fermented by a single culture of either Streptococcus thermophilus or Lactobacillus delbrueckii ssp. bulgaricus. The headspace technique was used for sample preparation, following identification and quantification by gas chromatography. During an 8‐h incubation period, mixed cultures were the most efficient in lowering the pH (from 6.30 to 4.8), followed by S. thermophilus (from 6.30 to 5.18) and L. bulgaricus (from 6.30 to 5.8). During the storage period, however, a single culture of L. bulgaricus decreased the pH more than S. thermophilus, but still less than the mixed commercial cultures. Plain yoghurts acquired in the market, those made with commercial starter cultures, and fermented milks obtained with single cultures showed, after 21 days of storage, concentrations of acetaldehyde from 11 to 35 mg/L, and of diacetyl from 0 to 0.85 mg/L. An increasing concentration of ethanol was observed during the storage period, and its production was observed even in the incubation stage of all products. It was also observed that the acetaldehyde concentration was inversely correlated to ethanol production in some products. The combination of headspace, identification and quantification techniques by gas chromatography in this work was efficient in the identification and quantification of the major aromatic compounds and ethanol content of yoghurt.
Aging alters PPARγ in rodent and human adipose tissue by modulating the balance in steroid receptor coactivator‐1
Authors: Miard Stéphanie , Dombrowski Luce , Carter Sophie , Boivin Louise , Picard Frédéric 
Published: May 2009

SummaryAge is an important risk factor for the development of metabolic diseases (e.g. obesity, diabetes and atherosclerosis). Yet, little is known about the molecular mechanisms occurring upon aging that affect energy metabolism. Although visceral white adipose tissue (vWAT) is known for its key impact on metabolism, recent studies have indicated it could also be a key regulator of lifespan, suggesting that it can serve as a node for age‐associated fat accretion. Here we show that aging triggers changes in the transcriptional milieu of the nuclear receptor peroxisome proliferator‐activated receptor gamma (PPARγ) in vWAT, which leads to a modified potential for transactivation of target genes upon ligand treatment. We found that in vWAT of mice, rats and men, aging induced a specific decrease in the expression of steroid receptor coactivator‐1 (SRC‐1), whose recruitment to PPARγ is associated with improved insulin sensitivity and low adipogenic activity. In contrast, aging and oxidative stress did not impact on PPARγ expression and PPARγ ligand production. Age‐induced loss of PPARγ/SRC‐1 interactions increased the binding of PPARγ to the promoter of the adipogenic gene aP2. These findings suggest that strategies aimed at increasing SRC‐1 expression and recruitment to PPARγ upon aging might help improve age‐associated metabolic disorders.
History and Historiography of the English East India Company: Past, Present, and Future!
Authors: Stern Philip J. 
Published: May 2009

AbstractThis article explores recent developments in the historiography of the English East India Company. It proposes that there has been an efflorescence of late in scholarship on the Company that is directly tied both to the resurgence of imperial studies in British history as well as to contemporary concerns such as globalization, border‐crossings, and transnationalism. These transformations have in turn begun to change some of the most basic narratives and assumptions about the Company's history. At the same time, they have also significantly widened the number and types of scholars interested in the Company, broadening its appeal beyond ‘Company studies’ to have relevance for a range of historical concerns, in British domestic history, Atlantic history, global history, as well as amongst literary scholars, geographers, sociologists, economists, and others.
Pharmacokinetics of tacrolimus co‐administered with adefovir dipivoxil to liver transplant recipients
Authors: Terrault Norah A. , Tran Tram T. , Schiff Eugene , McGuire Brendan M. , Brown Robert S. , Tupper Rebecca , Ramanathan Srini , Enejosa Jeffrey , Zhong Lijie , Zong Jian ,   for the Study 531 Team
Published: May 2009

AbstractBackground: Adefovir dipivoxil has activity against wild‐type and lamivudine‐resistant hepatitis B virus (HBV) and is frequently used to manage HBV infection in transplant recipients. Calcineurin inhibitors are a central component of immunosuppressive therapy.Aims: Study GS‐02‐531 was an open‐label, multicentre drug interaction trial to examine potential drug interactions between adefovir and tacrolimus in stable post‐transplant recipients.Materials and Methods: Sixteen non‐HBV‐infected post‐transplant recipients with median age 45.5 years (69% male, 44% Caucasian, 50% Hispanic and 6% Black) and stable hepatic and renal function on a stable daily dose of tacrolimus (2–10 mg total daily dose) were studied before (tacrolimus alone) and after co‐administration of adefovir 10 mg daily for 14 days (Days 1–14). Pharmacokinetic (PK) analyses utilized non‐compartmental methods.Results: The median elimination half‐life of tacrolimus was 14.47 and 12.59 h for Day 0 and Day 14 respectively. The geometric mean ratios for tacrolimus on Day 14 vs Day 0 were 105.2% [90% confidence interval (90% CI): 89.8–123%] for Cmax and 106.4% (90% CI: 92.9–122%) for AUCtau. Both 90% CIs for the ratios were contained within the predefined lack of interaction bounds of 80 and 125% (i.e. within the bounds for the equivalence assessment), indicating that these PK parameters of tacrolimus are not significantly altered by co‐administration of adefovir. Similarly, the observed adefovir PK parameters after 14 days of co‐administration with tacrolimus were comparable to historical data in non‐transplant patients receiving adefovir alone. Serum creatinine values were stable during the study period.Conclusion: There is no significant PK interaction between tacrolimus and adefovir co‐administered to liver transplant recipients for 14 days.
Paper Versus Electronic Medical Records: The Effects of Access on Physicians' Decisions to Use Complex Information Technologies*
Authors: Ilie Virginia , Van Slyke Craig , Parikh Mihir A. , Courtney James F. 
Published: May 2009

ABSTRACTThis study examines physicians' responses to complex information technologies (IT) in the health care supply chain. We extend individual‐level IT adoption models by incorporating a new construct: system accessibility. The main premise of the study is, when faced with a decision between alternate IT systems, individual users tend to select and make use of the technology or system that is most readily accessible. We discuss both physical and logical dimensions of accessibility as they relate to adoption of electronic medical records (EMR). Physical accessibility refers to the availability of computers that can be used to access EMR, while logical accessibility refers to the ease or difficulty of logging into the system. Using data from a survey of 199 physicians practicing in a large U.S. hospital, we show that, when deciding between the paper chart and EMR, accessibility is an important consideration in a physician's decision to use the system. Both dimensions of accessibility act as barriers to EMR use intentions through their indirect effect on physicians' perceptions of EMR usefulness and ease of use. Logical access also has a direct effect on EMR use intentions. We conclude that accessibility is an important factor that limits acceptance of complex IT such as EMR.
Strategic Purchases of Bundled Products in a Health Care Supply Chain Environment*
Authors: Ross Anthony D. , Jayaraman Vaidyanathan 
Published: May 2009

ABSTRACTRecent articles in the Wall Street Journal summarize the state of business practice in American hospitals by shedding light on the state of supply chain management practices and foci in today's health care supply chains. In health care, the single largest cost after labor is materials, and it has been documented that health care facilities can reduce the environmental impacts of the products and services they consume before regulatory problems arise or waste disposal costs increase by focusing on their upstream activities. Health care systems around the country consume significant quantities and varieties of products within the health delivery processes. Solving these environmental problems requires a much broader view involving collaborative efforts of professionals from different areas of health care to meet these challenges. The purchasing function bridges the gaps by providing a healthy dialogue on key environmental attributes within the health care supply chain. The concept of bundling new with refurbished products is gaining a lot of attention in the health care supply chain. This research describes a health care purchasing problem for bundling new and refurbished products of the type facing a growing number of large health care providers, and then proposes a methodology for evaluating the complex tradeoffs involved in bundling decisions for refurbished health care products. By exploiting some useful properties of the problem structure, our results provide buyers with useful insights for examining and selecting suppliers who are willing to offer bundles of new and refurbished products.
Barriers to Swift, Even Flow in the Internal Supply Chain of Perioperative Surgical Services Department: A Case Study*
Authors: Fredendall Lawrence D. , Craig Janet B. , Fowler Pat J. , Damali Uzay 
Published: May 2009

ABSTRACTThis research analyzes the internal service supply chain of a perioperative surgical services department of a nonacademic community hospital using the theory of swift and even flow as a theoretical lens. Performance data were gathered using an in‐depth case study and it was determined that the swift and even flow constructs did affect flow speed and variance, but did not account for all the effects observed. To understand the need for departments to coordinate their efforts with each other and how this affected flow, further analysis was conducted using insights from Pagell's (2004) theory of internal integration and Gittell's (2002) research about coordinating mechanisms. The findings suggest the need to incorporate a variable measuring supply chain coordination into the theory of swift and even flow.
Root canal re‐treatment of a mandibular second premolar with three root canals: a case report
Authors: Shokouhinejad Noushin 
Published: May 2009

AbstractAccurate diagnosis of root canal morphology and anatomy is essential for thorough shaping and cleaning of the entire root canal system and consequent successful root canal treatment. Mandibular premolars show a wide variety of root canal anatomy. This paper describes a case of mandibular second premolar with three root canals that has previously received an incomplete root canal treatment.
Effect of sodium ascorbate on bond strength of different adhesive systems to NaOCl‐treated dentin
Authors: Celik Cigdem , Erkut Selim , Gulsahi Kamran , Yamanel Kivanc , Kucukesmen Cigdem 
Published: May 2009

AbstractThe aim of this study was to evaluate the effects of sodium ascorbate on bond strength of different adhesive systems to NaOCl‐treated dentin. Eighty extracted molar teeth were used in the study. The buccal enamel surfaces were removed to obtain a flat dentin surface. The teeth were mounted in self‐curing resin and dentin surfaces were irrigated with NaOCl for 10 min. Half of the specimens were treated with sodium ascorbate for 10 min. The teeth were randomly assigned to four subgroups according to the adhesive systems used (Clearfil SE Bond, Clearfil Tri‐S Bond, Adper Prompt‐L‐Pop, Adper Single Bond 2). Bond strengths were determined with a Universal Testing Machine, at a crosshead speed of 0.5 mm/min. Data were statistically analysed using anova at a significance level of 0.05. Two‐way anova revealed that the effect of sodium ascorbate application on bond strength of adhesive systems to NaOCl‐treated dentin was statistically significant (P < 0.05). The bond strength results were significantly influenced by the application of sodium ascorbate (P < 0.05) and there was a significant difference between the adhesive systems (P < 0.05). Although statistically significant differences were not demonstrated in all adhesive resin groups, sodium ascorbate application after NaOCl treatment improved the bond strength values.
Effect of intravitreal bevacizumab (Avastin®) in neovascular age‐related macular degeneration using a treatment regimen based on optical coherence tomography: 6‐ and 12‐month results
Authors: Leydolt Christina , Michels Stephan , Prager Franz , Garhoefer Gerhard , Georgopoulos Michael , Polak Kaija , Schmidt‐Erfurth Ursula 
Published: May 2009

Abstract.Purpose:  To study the effect of intravitreal bevacizumab therapy on visual and anatomical outcomes in patients with neovascular age‐related macular degeneration (AMD) within a follow‐up period of 6 and 12 months.Methods:  A retrospective analysis of 102 eyes of 102 consecutive patients with neovascular AMD evaluated repeated intravitreal bevacizumab (1 or 2.5 mg) injections. Retreatment was performed following an optical coherence tomography (OCT)‐based regimen. Ophthalmic examination included best‐corrected visual acuity (BCVA), dilated fundus examination and OCT imaging. Data were analysed at baseline, 6 months (24 weeks) and 12 months (48 weeks) after treatment initiation.Results:  BCVA remained stable at 6 months (mean: 0.00 ± 0.41 logMAR; p = 0.95) and 12 months (mean: +0.02 ± 0.43 logMAR; loss of ∼ 1 letter; p = 0.70) after the first treatment. OCT retinal thickness decreased by a mean of −37.8 ± 101.6 μm (p < 0.05) compared to baseline at month 6 and −38.6 ± 93.3 μm (p < 0.05) at month 12. A mean of 2.6 ± 1.2 injections were needed to obtain absence of fluid by OCT, and the time to recurrence was 23 ± 11 weeks thereafter. There was no difference in BCVA and OCT outcomes between treatment‐naive eyes and eyes that had undergone prior treatment.Conclusion:  The 6‐ and 12‐month follow‐up of repeated intravitreal bevacizumab therapy in eyes with neovascular AMD demonstrated stabilization of vision and no safety concerns. An OCT‐based retreatment strategy appears appropriate in the management of patients treated with intravitreal bevacizumab.
Nursing caries: Literature review and report of a case managed under local anaesthesia
Authors: Johnston Timothy , Messer Louise Brearley 
Published: May 2009

AbstractAlthough the prevalence of dental caries in children has fallen in recent years, significant numbers of children are still treated for nursing caries. This form of rampant caries affects the primary dentition and causes rapid destruction of normally resistant surfaces. The treatment of nursing caries is multifactorial, involving the child, parents, dental team and other health care providers to ensure the restorative dental treatment is supported by parental education in caries prevention, oral hygiene and infant nutrition. This paper presents a literature review on the condition, followed by a case report of a child with nursing caries treated in the clinic under local anaesthesia.
Effects of splint therapy in TMJ dysfunction: A study using magnetic resonance imaging
Authors: Chen Chien W. , Boulton Justin L. , Gage John P. 
Published: May 2009

AbstractThis pilot study was undertaken to correlate clinical and MRI diagnoses in seven symptomatic TMJ dysfunction patients and to account, if possible, for the clinical improvement in the signs and symptoms after the use of a maxillary stabilizing splint. The symptomatic TMJs were evaluated by means of MRI prior to splint insertion. Sagittal open/closed, and coronal closed images were obtained with a 0.3 T Fonar MR Scanner. A follow‐up MRI was taken after three months of splint therapy for the purposes of a comparative study.All subjects responded positively even at the early phase of splint treatment. By the end of the three month period, six subjects experienced full remission of pain in the TMJ and associated masticatory muscles with one subject experiencing only partial remission following therapy. Baseline MRI study revealed that only three subjects had anterior disc displacement while the other four subjects had normal disc/condyle relationships and morphology. In the follow‐up MRI study, there were no signs of recapture of the three anteriorly displaced discs despite there being evidence of improved jaw movement and remission of pain symptoms.The use of MRI in this preliminary study indicates that some but not all TMJ pain dysfunction syndromes are caused by internal derangements of the joint. A larger MRI study using the same clinical parameters is indicated for future research.
A questionnaire survey of dentists regarding knowledge and perceived competence in resuscitation and occurrence of resuscitation emergencies
Authors: Chapman P. J. 
Published: May 2009

AbstractLittle information has been published on the knowledge and perceived competence of dentists in resuscitation or the occurrence of resuscitation emergencies in dental practice. Further, no such surveys have been done in Australia. A postal survey was therefore devised and the names of 350 dentists were randomly selected from the Australian Dental Association national membership registry. The response rate was approximately 45 per cent and the main results included: just under half of the respondents felt they were competent in basic resuscitation at the time of graduation, that is, in expired air resuscitation (EAR) and cardiopulmonary resuscitation (CPR); just less than two‐thirds had undertaken resuscitation training since graduation; about three‐quarters felt they would be able to perform EAR and almost two‐thirds felt they would be able to perform CPR; almost 90 per cent gained a satisfactory score in a Resuscitation Quiz included in the survey; and just over 5 per cent had had to resuscitate a patient.
Ectopic supernumerary teeth as a predisposing cause in localized periodontitis. Case report
Authors: Hou Guey‐Lin , Lin Cheng‐Chung , Tsai Chi‐Cheng 
Published: May 2009

AbstractSupernumerary teeth are relatively common in the maxillary incisor and molar areas. However, bilateral ectopic, fully erupted supernumerary mesiodentes are relatively rare. The present case documents a patient with localized periodontitis of the maxillary first and second molars associated with bilaterally erupted supernumerary teeth located in proximity to the buccal embrasure space between the molars. Combined clinical data suggested that these ectopic mesiodentes predisposed or contributed to the development of localized periodontitis.
Temporomandibular disorders. 1. Clinical evaluation
Authors: Dimitroulis George , Dolwick M. Franklin , Gremillion Henry A. 
Published: May 2009

AbstractThe treatment of temporomandibular disorders continues to provide dental practitioners with a difficult challenge that has yet to overcome numerous major obstacles. In this, the first of a series of three articles, an overview of the current understanding of the diagnosis of temporomandibular disorders will be presented. The subsequent two articles will present an overview of the management strategies that have appeared in the literature in recent years.
Methodological aspects of a computer‐assisted telephone interview survey of oral health
Authors: Slade Gary D. , Brennan David , Spencer A. John 
Published: May 2009

AbstractDespite the reported benefits of computer‐assisted telephone interview (CATI) methods, experiences from their use in Australian oral health surveys have not been described. This report aimed to present methodological aspects of a CATI survey conducted in the five mainland states. A response rate of 66 per cent was obtained, yielding 4050 completed interviews. Analysis revealed generally small levels of non‐response bias: persons who avoided or delayed dental treatment because of cost and non‐health card holders were harder to contact, while non‐English speakers and persons aged 20–29 years were less likely to participate. A total of 1770 person hours of interview time was spent on the survey: 64.5 per cent of that time was spent on the telephone with an average of 10 minutes 17 seconds per call (13 minutes 37 seconds per completed call). Only seven questions had missing data for more than 1 per cent of respondents. Comprehension of questions and cooperation with the interview was rated by interviewers as ‘good’ or ‘very good’ for more than 90 per cent of respondents. The CATI method was highly efficient and yielded good quality data for the survey.