bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tornadic Supercell Environments Analyzed Using Surface and Reanalysis Data: A Spatiotemporal Relational Data-Mining Approach
Authors: Gagne David John , McGovern Amy , Basara Jeffrey B. , Brown Rodger A. 
Published: June 2012

AbstractOklahoma Mesonet surface data and North American Regional Reanalysis data were integrated with the tracks of over 900 tornadic and nontornadic supercell thunderstorms in Oklahoma from 1994 to 2003 to observe the evolution of near-storm environments with data currently available to operational forecasters. These data are used to train a complex data-mining algorithm that can analyze the variability of meteorological data in both space and time and produce a probabilistic prediction of tornadogenesis given variables describing the near-storm environment. The algorithm was assessed for utility in four ways. First, its probability forecasts were scored. The algorithm did produce some useful skill in discriminating between tornadic and nontornadic supercells as well as in producing reliable probabilities. Second, its selection of relevant attributes was assessed for physical significance. Surface thermodynamic parameters, instability, and bulk wind shear were among the most significant attributes. Third, the algorithm’s skill was compared with the skill of single variables commonly used for tornado prediction. The algorithm did noticeably outperform all of the single variables, including composite parameters. Fourth, the situational variations of the predictions from the algorithm were shown in case studies. They revealed instances both in which the algorithm excelled and in which the algorithm was limited.
Interannual Tropospheric Aerosol Variability in the Late Twentieth Century and Its Impact on Tropical Atlantic and West African Climate by Direct and Semidirect Effects
Authors: Mahajan Salil , Evans Katherine J. , Truesdale John E. , Hack James J. , Lamarque Jean-François 
Published: June 2012

Abstract
A new high-resolution global tropospheric aerosol dataset with monthly resolution is generated using version 4 of the Community Atmosphere Model (CAM4) coupled to a bulk aerosol model and forced with recent estimates of surface emissions for the period 1961–2000 to identify tropospheric aerosol-induced interannual climate variations. The surface emissions dataset is constructed from phase 5 of the Coupled Model Intercomparison Project (CMIP5) decadal-resolution surface emissions dataset to include reanalysis of tropospheric chemical composition [40-yr Reanalysis of Tropospheric Chemical Composition (RETRO)] wildfire monthly emissions data. A four-member ensemble run is conducted using the spectral configuration of CAM4, forced with the new tropospheric aerosol dataset and prescribed with observed sea surface temperature, sea ice, and greenhouse gases. CAM4 only simulates the direct and semidirect effects of aerosols on the climate. The simulations reveal that variations in tropospheric aerosol levels can induce significant regional climate variability on the interannual time scales. Regression analyses over tropical Atlantic and Africa suggest that increasing dust aerosols can cool the North African landmass and shift convection southward from West Africa into the Gulf of Guinea in the spring season. Further, it is found that carbonaceous aerosols emanating from the southwestern African savannas can significantly cool the region and increase the marine stratocumulus cloud cover over the southeast tropical Atlantic Ocean by aerosol-induced diabatic heating of the free troposphere above the low clouds. Experiments conducted with CAM4 coupled to a slab ocean model suggest that present-day aerosols can cool the tropical North Atlantic and shift the intertropical convergence zone southward and can reduce the ocean mixed layer temperature beneath the increased marine stratocumulus clouds in the southeastern tropical Atlantic.
Comparison between Dual-Doppler and EnKF Storm-Scale Wind Analyses: Observing System Simulation Experiments with a Supercell Thunderstorm
Authors: Potvin Corey K. , Wicker Louis J. 
Published: June 2012

AbstractKinematical analyses of mobile radar observations are critical to advancing the understanding of supercell thunderstorms. Maximizing the accuracy of these and subsequent dynamical analyses, and appropriately characterizing the uncertainty in ensuing conclusions about storm structure and processes, requires thorough knowledge of the typical errors obtained using different retrieval techniques. This study adopts an observing system simulation experiment (OSSE) framework to explore the errors obtained from ensemble Kalman filter (EnKF) assimilation versus dual-Doppler analysis (DDA) of storm-scale mobile radar data. The radar characteristics and EnKF model errors are varied to explore a range of plausible scenarios.When dual-radar data are assimilated, the EnKF produces substantially better wind retrievals at higher altitudes, where DDAs are more sensitive to unaccounted flow evolution, and in data-sparse regions such as the storm inflow sector. Near the ground, however, the EnKF analyses are comparable to the DDAs when the radar cross-beam angles (CBAs) are poor, and slightly worse than the DDAs when the CBAs are optimal. In the single-radar case, the wind analyses benefit substantially from using finer grid spacing than in the dual-radar case for the objective analysis of radar observations. The analyses generally degrade when only single-radar data are assimilated, particularly when microphysical parameterization or low-level environmental wind errors are introduced. In some instances, this leads to large errors in low-level vorticity stretching and Lagrangian circulation calculations. Nevertheless, the results show that while multiradar observations of supercells are always preferable, judicious use of single-radar EnKF assimilation can yield useful analyses.
Social Capital and Self-Rated Health Among Older Korean Immigrants
Authors: Kim Bum Jung , Harris Lesley Maradik 
Published: June 2012

Purpose of the Study: The objective of this article is to investigate determinants of self-rated health and describe their association with social capital and socioeconomic characteristics among older Korean immigrants. Method: A cross-sectional study of 205 older Korean immigrants (aged 60 years and older) was conducted in Los Angeles county. Independent variables included age, gender, marital status, income of the older Koreans, and social capital included social norms, trust, partnership with the community, information sharing, and political participation. Self-rated health was the dependent variable. Results: Descriptive analyses were done to show group differences in self-rated health and logistic regression analyses to identify determinants of self-rated health. Gender (male), high income, and high levels of information sharing were significant determinants of high self-rated health status among older Korean immigrants. Implications: This population-based study provides empirical evidence that gender, income, and information sharing are directly associated with the self-rated health status of older Korean immigrants.
State Legislative Committees and Economic Connections: Expertise and Industry Service
Authors: Battista James Coleman 
Published: June 2012

AbstractAmerican state legislators commonly remain connected to the market, giving them the potential for unique expertise on how policy affects the industries they are connected to and the opportunity to help enact laws favoring those industries. This paper describes the extent to which state legislative committees are populated by legislators with economic connections to their jurisdiction, and analyzes appointment patterns to help distinguish stacking to tap expertise from stacking to serve an industry. I find that a substantial minority of committees are stacked with connected legislators. Appointment patterns show limited evidence for expertise in education and health care, for industry service in banking, and for both in agriculture.
Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish
Authors: Wilkinson Robert N. , Koudijs Marco J. , Patient Roger K. , Ingham Philip W. , Schulte-Merker Stefan , van Eeden Fredericus J. M. 
Published: June 2012

AbstractMultiple signaling pathways control the specification of endothelial cells (ECs) to become arteries or veins during vertebrate embryogenesis. Current models propose that a cascade of Hedgehog (Hh), vascular endothelial growth factor (VEGF), and Notch signaling acts instructively on ECs to control the choice between arterial or venous fate. Differences in the phenotypes induced by Hh, VEGF, or Notch inhibition suggest that not all of the effects of Hh on arteriovenous specification are mediated by VEGF. We establish that full derepression of the Hh pathway in ptc1;ptc2 mutants converts the posterior cardinal vein into a second arterial vessel that manifests intact arterial gene expression, intersegmental vessel sprouting, and HSC gene expression. Importantly, although VEGF was thought to be absolutely essential for arterial fates, we find that normal and ectopic arterial differentiation can occur without VEGF signaling in ptc1;ptc2 mutants. Furthermore, Hh is able to bypass VEGF to induce arterial differentiation in ECs via the calcitonin receptor-like receptor, thus revealing a surprising complexity in the interplay between Hh and VEGF signaling during arteriovenous specification. Finally, our experiments establish a dual function of Hh during induction of runx1+ HSCs.
Assessment of anti-depressant effect of nelumbinis semen on rats under chronic mild stress and its subchronic oral toxicity in rats and beagle dogs
Authors: Chung Hwan-Suck , Lee Hye Jeong , Shim Insop , Bae Hyunsu 
Published: June 2012

Abstract

Background
Previously, we examined the antidepressant effects of Nelumbinis Semen (NS). In this study, we assessed the anti-depressant effects of NS in the forced swimming test and chronic mild stress (CMS) models of depression and its oral toxicity in rats and dogs.

Methods
In the forced swimming test, NS was intraperitoneally injected before 24 h, 5 h and 1 h of forced swimming test. And the rats were forced to swim for 5 min, the duration of immobility was observed. In CMS models, animals were exposed to a variety of CMS for 8 weeks in order to induce depression-like symptoms. They were treated with NS for the last four weeks of the 8-week CMS and then an open field test was conducted. The anti-depression effects were evaluated based on a measured index, which consisted of visiting counts, start latency, rearing number and grooming time. In the toxicological studies, NS was administered to rats by gavages for 13 weeks at doses of 0, 500, 1000, and 2000 mg/kg/day. To assess the toxicity of NS in beagle dogs, NS was administered orally for 28 days at doses of 0, 500, 1000, 2000 and 4000 mg/kg/day.

Results
400 mg/kg of NS had the lowest immobility times in forced swimming test. And NS significantly reversed the decreased visiting counts, rearing number and grooming time caused by CMS. In addition, NS treatment significantly decreased the start latency. No treatment-related toxicity was detected during 13 weeks administration in rats and 28 days administration in dogs.

Conclusions
Based on the results of this study and previous reports that have examined the anti-depressive effects of NS, NS holds great promise for use in the treatment of depression without causing any adverse effects or toxicities.
Hospital costs of nosocomial multi-drug resistant Pseudomonas aeruginosa acquisition
Authors: Morales Eva , Cots Francesc , Sala Maria , Comas Mercè , Belvis Francesc , Riu Marta , Salvadó Margarita , Grau Santiago , Horcajada Juan P , Montero Maria Milagro , Castells Xavier 
Published: June 2012

Abstract

Background
We aimed to assess the hospital economic costs of nosocomial multi-drug resistant Pseudomonas aeruginosa acquisition.

Methods
A retrospective study of all hospital admissions between January 1, 2005, and December 31, 2006 was carried out in a 420-bed, urban, tertiary-care teaching hospital in Barcelona (Spain). All patients with a first positive clinical culture for P. aeruginosa more than 48 h after admission were included. Patient and hospitalization characteristics were collected from hospital and microbiology laboratory computerized records. According to antibiotic susceptibility, isolates were classified as non-resistant, resistant and multi-drug resistant. Cost estimation was based on a full-costing cost accounting system and on the criteria of clinical Activity-Based Costing methods. Multivariate analyses were performed using generalized linear models of log-transformed costs.

Results
Cost estimations were available for 402 nosocomial incident P. aeruginosa positive cultures. Their distribution by antibiotic susceptibility pattern was 37.1% non-resistant, 29.6% resistant and 33.3% multi-drug resistant. The total mean economic cost per admission of patients with multi-drug resistant P. aeruginosa strains was higher than that for non-resistant strains (15,265 vs. 4,933 Euros). In multivariate analysis, resistant and multi-drug resistant strains were independently predictive of an increased hospital total cost in compared with non-resistant strains (the incremental increase in total hospital cost was more than 1.37-fold and 1.77-fold that for non-resistant strains, respectively).

Conclusions

P. aeruginosa multi-drug resistance independently predicted higher hospital costs with a more than 70% increase per admission compared with non-resistant strains. Prevention of the nosocomial emergence and spread of antimicrobial resistant microorganisms is essential to limit the strong economic impact.
Proteins differentially expressed in elicited cell suspension culture of Podophyllum hexandrum with enhanced podophyllotoxin content
Authors: Bhattacharyya Dipto , Sinha Ragini , Ghanta Srijani , Chakraborty Amrita , Hazra Saptarshi , Chattopadhyay Sharmila 
Published: June 2012

Abstract

Background
Podophyllotoxin (PTOX), the precursor for semi-synthesis of cancer therapeutics like etoposide, teniposide and etophos, is primarily obtained from an endangered medicinal herb, Podophyllum hexandrum Royle. PTOX, a lignan is biosynthetically derived from the phenylpropanoid pathway. The aim of this study is to investigate changes in the P. hexandrum cell proteome potentially related to PTOX accumulation in response to methyl jasmonate (MeJA) elicitation. High-resolution two-dimensional gel electrophoresis (2-DE) followed by colloidal Coomassie staining and mass spectrometric analysis was used to detect statistically significant changes in cell’s proteome.

Result
The HPLC analysis showed approximately 7–8 fold change in accumulation of PTOX, in the 12day old cell suspension culture (i.e. after 9days of elicitation) elicited with 100 μM MeJA as compared to the control. Using 2-DE a total of 233 spots was detected, out of which 105 spots were identified by MALDI TOF-TOF MS/MS. Data were subjected to functional annotation from a biological point of view through KEGG. The phenylpropanoid and monolignol pathway enzymes were identified, amongst these, chalcone synthase, polyphenol oxidase, caffeoyl CoA 3-O-methyltransferase, S-adenosyl-L-methionine-dependent methyltransferases, caffeic acid-O-methyl transferase etc. are noted as important. The relation of other differentially accumulated proteins with varied effects caused by elicitors on P. hexandrum cells namely stress and defense related protein, transcription and DNA replication and signaling are also discussed.

Conclusions
Elicitor-induced PTOX accumulation in P. hexandrum cell cultures provides a responsive model system to profile modulations in proteins related to phenylpropanoid/monolignol biosynthesis and other defense responses. Present findings form a baseline for future investigation on a non-sequenced medicinal herb P. hexandrum at molecular level.
Ferroelectric memory based on nanostructures
Authors: Liu Xingqiang , Liu Yueli , Chen Wen , Li Jinchai , Liao Lei 
Published: June 2012

Abstract
In the past decades, ferroelectric materials have attracted wide attention due to their applications in nonvolatile memory devices (NVMDs) rendered by the electrically switchable spontaneous polarizations. Furthermore, the combination of ferroelectric and nanomaterials opens a new route to fabricating a nanoscale memory device with ultrahigh memory integration, which greatly eases the ever increasing scaling and economic challenges encountered in the traditional semiconductor industry. In this review, we summarize the recent development of the nonvolatile ferroelectric field effect transistor (FeFET) memory devices based on nanostructures. The operating principles of FeFET are introduced first, followed by the discussion of the real FeFET memory nanodevices based on oxide nanowires, nanoparticles, semiconductor nanotetrapods, carbon nanotubes, and graphene. Finally, we present the opportunities and challenges in nanomemory devices and our views on the future prospects of NVMDs.
Efficacy, safety and tolerability of ongoing statin plus ezetimibe versus doubling the ongoing statin dose in hypercholesterolemic Taiwanese patients: an open-label, randomized clinical trial
Authors: Yu Chih-Chieh , Lai Wen-Ter , Shih Kuang-Chung , Lin Tsung-Hsien , Lu Chieh-Hua , Lai Hung-Jen , Hanson Mary E , Hwang Juey-Jen 
Published: June 2012

Abstract

Background
Reducing low-density lipoprotein cholesterol (LDL-C) is associated with reduced risk for major coronary events. Despite statin efficacy, a considerable proportion of statin-treated hypercholesterolemic patients fail to reach therapeutic LDL-C targets as defined by guidelines. This study compared the efficacy of ezetimibe added to ongoing statins with doubling the dose of ongoing statin in a population of Taiwanese patients with hypercholesterolemia.

Methods
This was a randomized, open-label, parallel-group comparison study of ezetimibe 10 mg added to ongoing statin compared with doubling the dose of ongoing statin. Adult Taiwanese hypercholesterolemic patients not at optimal LDL-C levels with previous statin treatment were randomized (N = 83) to ongoing statin + ezetimibe (simvastatin, atorvastatin or pravastatin + ezetimibe at doses of 20/10, 10/10 or 20/10 mg) or doubling the dose of ongoing statin (simvastatin 40 mg, atorvastatin 20 mg or pravastatin 40 mg) for 8 weeks. Percent change in total cholesterol, LDL-C, high-density lipoprotein cholesterol (HDL-C) and triglycerides, and specified safety parameters were assessed at 4 and 8 weeks.

Results
At 8 weeks, patients treated with statin + ezetimibe experienced significantly greater reductions compared with doubling the statin dose in LDL-C (26.2% vs 17.9%, p = 0.0026) and total cholesterol (20.8% vs 12.2%, p = 0.0003). Percentage of patients achieving treatment goal was greater for statin + ezetimibe (58.6%) vs doubling statin (41.2%), but the difference was not statistically significant (p = 0.1675). The safety and tolerability profiles were similar between treatments.

Conclusion
Ezetimibe added to ongoing statin therapy resulted in significantly greater lipid-lowering compared with doubling the dose of statin in Taiwanese patients with hypercholesterolemia. Studies to assess clinical outcome benefit are ongoing.

Trial registration
Registered at ClinicalTrials.gov: NCT00652327
Implications of endotracheal tube biofilm in ventilator-associated pneumonia response: a state of concept
Authors: Gil-Perotin Sara , Ramirez Paula , Marti Veronica , Sahuquillo Jose Miguel , Gonzalez Eva , Calleja Isabel , Menendez Rosario , Bonastre Juan 
Published: June 2012

Abstract
Introduction
Biofilm in endotracheal tubes (ETT) of ventilated patients has been suggested to play a role in the development of ventilator-associated pneumonia (VAP). Our purpose was to analyze the formation of ETT biofilm and its implication in the response and relapse of VAP.

Methods
We performed a prospective, observational study in a medical intensive care unit. Patients mechanically ventilated for more than 24 hours were consecutively included. We obtained surveillance endotracheal aspirates (ETA) twice weekly and, at extubation, ETTs were processed for microbiological assessment and scanning electron microscopy.

Results
Eighty-seven percent of the patients were colonized based on ETA cultures. Biofilm was found in 95% of the ETTs. In 56% of the cases, the same microorganism grew in ETA and biofilm. In both samples the most frequent bacteria isolated were Acinetobacter baumannii and Pseudomonas aeruginosa. Nineteen percent of the patients developed VAP (N = 14), and etiology was predicted by ETA in 100% of the cases. Despite appropriate antibiotic treatment, bacteria involved in VAP were found in biofilm (50%). In this situation, microbial persistence and impaired response to treatment (treatment failure and relapse) were more frequent (100% vs 29%, P = 0.021; 57% vs 14%, P = 0.133).

Conclusions
Airway bacterial colonization and biofilm formation on ETTs are early and frequent events in ventilated patients. There is microbiological continuity between airway colonization, biofilm formation and VAP development. Biofilm stands as a pathogenic mechanism for microbial persistence, and impaired response to treatment in VAP.
Negative Regulation of Pancreatic and Duodenal Homeobox-1 by Somatostatin Receptor Subtype 5
Authors: Zhou Guisheng , Liu Shi-He , Shahi Kelly M. , Wang Hua , Duan Xueyan , Lin Xia , Feng Xin-Hua , Li Min , Fisher William E. , DeMayo Francesco J. , Dawson David , Brunicardi F. Charles 
Published: June 2012

AbstractSomatostatin receptor subtype 5 (SSTR5) mediates the inhibitory effect of somatostatin and its analogs on insulin expression/secretion and islet cell proliferation. We provide biochemical and genetic evidence that SSTR5 exerted its physiological actions via down-regulating pancreatic and duodenal homeobox-1 (PDX-1), a β-cell-specific homeodomain-containing transcription factor. Cotransfection of SSTR5 with PDX-1 resulted in dose-dependent inhibition of PDX-1 expression in human embryonic kidney 293 cells. SSTR5 agonist RPL-1980 inhibited PDX-1 expression and abolished glucagon-like peptide 1-stimulated PDX-1 expression in mouse insulinoma β-TC-6 cells. SSTR5 knockdown by short hairpin RNA led to increased PDX-1 expression that was accompanied by enhanced insulin secretion stimulated by high glucose in β-TC6 cells and alternated expressions of cell cycle proteins that favor cell proliferation in mouse insulinoma MIN6 cells. Quantitative RT-PCR analysis showed that cotransfected SSTR5 inhibited PDX-1 mRNA expression, whereas knockdown of SSTR5 increased PDX-1 mRNA expression. In addition, we found that cotransfected wild-type SSTR5 increased PDX-1 ubiquitination in human embryonic kidney 293 cells, whereas SSTR5 P335L, a hypofunctional single nucleotide polymorphism of SSTR5, inhibited PDX-1 ubiquitination. SSTR5 knockout resulted in increased expression of PDX-1, insulin, and proliferating cell nuclear antigen in the islets of sstr−/− mice. Immunohistochemistry analysis showed that SSTR5 P335L was associated with elevated expression of PDX-1 in human pancreatic neuroendocrine tumor. Taken together, our studies demonstrated that SSTR5 is a negative regulator for PDX-1 expression and that SSTR5 may mediate the inhibitory effects of somatostatin and its analogs on insulin expression/secretion and cell proliferation via down-regulating PDX-1 at both transcriptional and posttranslational levels.