bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mental health literacy and associated factors among traditional healers of Jimma town, southwest, Ethiopia 2020: a community based, cross-sectional study
Authors: Mideksa Gudeta , Tesfaye Elias , Yitayih Yimenu , Sime Yohanes , Aliye Kemal , Gizaw Abraham Tamirat 
Published: May 2024

BackgroundTraditional healers are in the front line to give the mental healthcare service in developing countries like Ethiopia. In Ethiopia, different studies were done focusing on the role of traditional medicine and perception of the community toward traditional medicine. However, there is paucity of studies, which shows the level of mental health literacy among traditional healers. Therefore, this study intended to mental health literacy level of traditional healers in Jimma town, Ethiopia.MethodA community-based cross-sectional study design was employed among 310 participants. To select the participants from Jimma town, a stratified random sampling method was utilized from August 1 to September 30, 2020. The Mental Health Literacy Questionnaire was used to assess mental health literacy for assessment of mental health literacy among traditional healers. The collected data were coded and entered into EpiData version 4.6 and exported to SPSS version 25.0 for analysis. Bivariate and multivariable linear regression was used for data analysis.ResultThe finding of this study showed that the samples of traditional healers found in Jimma town scored a total mean of 95.91 ± 3.0025 for mental health literacy. Age [β = −0.052 (95% CI: −0.078, −0.026)], year of experience [β = 0.095 (95% CI: 0.067, 0.123)], family history of mental illness [β = 1.709 (95% CI: 0.543, 2.360)], history of professional help seeking on mental illness [β = 0.501 (95% CI: 0.715, 2.288)], history of getting information of mental illness on media [β = 0.941 (95% CI: 0.345, 1.538)], training on mental health [β = 2.213 (995% CI: 1.520, 2.906)], history of treating mental illness [β = 1.676 (95% CI: 0.808, 2.544)], and informal education [β = −1.664 (95% CI: −2.081, −1.247)] were factors significantly associated with MHL.ConclusionThe mental health literacy of traditional healers mean score is lower than the mean score of other studies. Age, year of experience, training on mental illness, family history, history of professional help seeking, history of treating mental illness, information on mental illness, and informal education are significantly associated with mental health literacy. Therefore, structured training is very important to improve their level of mental health literacy.
Depressive symptoms and all-cause mortality among middle-aged and older people in China and associations with chronic diseases
Authors: Zhu Lan , Wang Yixi , Li Jiaqi , Zhou Huan , Li Ningxiu , Wang Yuanyuan 
Published: May 2024

IntroductionIt remains unclear whether depressive symptoms are associated with increased all-cause mortality and to what extent depressive symptoms are associated with chronic disease and all-cause mortality. The study aims to explore the relationship between depressive symptoms and all-cause mortality, and how depressive symptoms may, in turn, affect all-cause mortality among Chinese middle-aged and older people through chronic diseases.MethodsData were collected from the China Health and Retirement Longitudinal Study (CHARLS). This cohort study involved 13,855 individuals from Wave 1 (2011) to Wave 6 (2020) of the CHARLS, which is a nationally representative survey that collects information from Chinese residents ages 45 and older to explore intrinsic mechanisms between depressive symptoms and all-cause mortality. The Center for Epidemiological Studies Depression Scale (CES-D-10) was validated through the CHARLS. Covariates included socioeconomic variables, living habits, and self-reported history of chronic diseases. Kaplan–Meier curves depicted mortality rates by depressive symptom levels, with Cox proportional hazards regression models estimating the hazard ratios (HRs) of all-cause mortality.ResultsOut of the total 13,855 participants included, the median (Q1, Q3) age was 58.00 (51.00, 63.00) years. Adjusted for all covariates, middle-aged and older adults with depressive symptoms had a higher all-cause mortality rate (HR = 1.20 [95% CI, 1.09–1.33]). An increased rate was observed for 55–64 years old (HR = 1.23 [95% CI, 1.03–1.47]) and more than 65 years old (HR = 1.32 [95% CI, 1.18–1.49]), agricultural Hukou (HR = 1.44, [95% CI, 1.30–1.59]), and nonagricultural workload (HR = 1.81 [95% CI, 1.61–2.03]). Depressive symptoms increased the risks of all-cause mortality among patients with hypertension (HR = 1.19 [95% CI, 1.00–1.40]), diabetes (HR = 1.41[95% CI, 1.02–1.95]), and arthritis (HR = 1.29 [95% CI, 1.09–1.51]).ConclusionDepressive symptoms raise all-cause mortality risk, particularly in those aged 55 and above, rural household registration (agricultural Hukou), nonagricultural workers, and middle-aged and older people with hypertension, diabetes, and arthritis. Our findings through the longitudinal data collected in this study offer valuable insights for interventions targeting depression, such as early detection, integrated chronic disease care management, and healthy lifestyles; and community support for depressive symptoms may help to reduce mortality in middle-aged and older people.
The concentration of maternal sacubitril/valsartan transferred into human milk is negligible
Authors: Falconi Sirin , Okimi Abiodun , Wesley Shaun , Sethi Pooja , Datta Palika , Krutsch Kaytlin 
Published: May 2024

BackgroundPeripartum cardiomyopathy (PPCM) is a common cause of heart failure (HF) in the peripartum. Some medications are considered safe while breastfeeding. However, sacubitril/valsartan (Entresto), while efficacious, is not recommended in breastfeeding women due to concerns about adverse infant development, and no published data suggest otherwise.ObjectivesThis study aimed to assess the transfer of sacubitril/valsartan into human milk and evaluate the infant’s risk of drug exposure.MethodsThe InfantRisk Human Milk Biorepository released samples and corresponding health information from five breastfeeding maternal–infant dyads exposed to sacubitril/valsartan. Sacubitril, valsartan, and LBQ657 (sacubitril active metabolite) concentrations were determined using liquid chromatography-mass spectrometry (LC/MS/MS) from timed samples 0, 1, 2, 4, 6, 8, 10, and 12 h following medication administration at steady state conditions.ResultsValsartan levels were below the detection limit of 0.19 ng/mL in all milk samples. Sacubitril was measurable in all milk samples of the five participants, peaking 1 h after drug administration at a mean concentration of 1.52 ng/mL for a total infant dose of 0.00049 mg/kg/12 h and a relative infant dose (RID) calculated at 0.01%. The maximum concentration of its active metabolite LBQ657 in the milk samples was observed 4 h after medication administration and declined over the remaining 12-h dosing interval, for an average concentration of 9.5 ng/mL. The total infant dose was 0.00071 mg/kg/12 h, and the RID was 0.22%. Two mothers reported continuing to breastfeed while taking sacubitril/valsartan; both mothers stated observing no negative effects in their breastfed infants.ConclusionThe transfer of sacubitril/valsartan into human milk is minimal. These concentrations are unlikely to pose a significant risk to breastfeeding infants, with a combined calculated RID of &lt;0.25%, which is far lower than the industry safety standards (RID &lt;10%).
Predictive analysis of groundwater balance and assessment of safe yield using a probabilistic groundwater model for the Dead Sea Basin
Authors: Al Atawneh Dima , Janardhanan Sreekanth , Cartwright Nick , Bertone Edoardo , Doble Rebecca 
Published: May 2024

IntroductionGroundwater in the Middle East and North Africa region is a critical component of the water supply budget due to a (semi-)arid climate and hence limited surface water resources. Despite the significance, factors affecting the groundwater balance and overall sustainability of the resource are often poorly understood. This often includes recharge and discharge characteristics, groundwater extraction and impacts of climate change. The present study investigates the groundwater balance in the Dead Sea Basin aquifer in Jordan using a groundwater flow model developed using the MODFLOW.MethodsThe study aimed to simulate groundwater balance components and their effect on estimation of the aquifer's safe yield, and to also undertake a preliminary analysis of the impact of climate change on groundwater levels in the aquifer. Model calibration and predictive analysis was undertaken using a probabilistic modeling workflow. Spatially heterogeneous groundwater recharge for the historical period was estimated as a function of rainfall by simultaneously calibrating the recharge and aquifer hydraulic property parameters.Results and discussionThe model indicated that annual average recharge constituted 5.1% of the precipitation over a simulation period of 6 years. The effect of groundwater recharge and discharge components were evaluated in the context of estimation of safe yield of the aquifer. The average annual safe yield is estimated as ~8.0 mm corresponding to the 80% of the calibrated recharge value. Simulated groundwater levels matched well with the declining trends in observed water levels which are indicative of unsustainable use. Long-term simulation of groundwater levels indicated that current conditions would result in large drawdown in groundwater levels by the end of the century. Simulation of climate change scenarios using projected estimates of rainfall and evaporation indicates that climate change scenarios would further exacerbate groundwater levels by relatively small amounts. These findings highlight the need to simulate the groundwater balance to better understand the water availability and future sustainability.
Electromyography of shoulder muscles in individuals without scapular dyskinesis during closed kinetic chain exercises on stable and unstable surfaces: a systematic review and meta-analysis
Authors: Arghadeh Ramin , Alizadeh Mohammad Hossein , Minoonejad Hooman , Sheikhhoseini Rahman , Asgari Mojtaba , Jaitner Thomas 
Published: May 2024

IntroductionUnstable surfaces are commonly utilized to enhance the flexibility of the musculoskeletal system for achieving training or rehabilitation goals. However, their effects on shoulder muscle activation during various push-up (PU) exercises have not been thoroughly investigated. Therefore, the purpose of this study was to synthesize electromyography (EMG) data of shoulder muscles in individuals without scapular dyskinesis performing different PU exercises on both stable and unstable surfaces.MethodsA systematic online search was conducted in electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar, up to January 16, 2024, using predefined sets of keywords. Out of the 1,971 titles and abstracts screened, 80 articles were reviewed in detail by two independent researchers to check the eligibility, of which 28 eligible studies were ultimately included. Following assessment of the quality and risk of bias, the studies were categorized based on exercises and muscle groups, and a meta-analysis using a random-effects model was performed to estimate the overall effect size.ResultsThe use of unstable surfaces led to a decrease in anterior deltoid activity during PU [P = 0.032;I2 = 91.34%; SMD = −0.630 (95% CI −1.205, −0.055)], an increase in pectoralis major activity during PU [P = 0.006;I2 = 63.72%; SMD = 0.282 (95% CI 0.079, 0.484)], as well as during knee PU [P = 0.018;I2 = 32.29%; SMD = 0.309 (95% CI 0.052, 0.565)], and an increase in triceps brachii activity during PU [P = 0.000;I2 = 85.05%; SMD = 0.813 (95% CI 0.457, 1.168)], knee PU [P = 0.000;I2 = 0.00%; SMD = 0.589 (95% CI 0.288, 0.891)], as well as during push-up plus [P = 0.006;I2 = 13.16%; SMD = 0.563 (95% CI 0.161, 0.965)]. However, the use of unstable surfaces did not show a significant effect on the EMG activity of the pectoralis major during push-up plus [P = 0.312;I2 = 22.82%; SMD = 0.207 (95% CI −0.194, 0.609)].ConclusionsUnstable surfaces can modulate muscle activity in different PU exercises, while the effects on the targeted muscles depend on the type of exercise. The findings of this review provide a framework based on the level of activity of each shoulder muscle during different PU exercises, which can help coaches, trainers, and sports therapists select the most suitable type of PU for designing training or rehabilitation programs. Particularly, the most suitable exercise for increasing anterior deltoid activity is PU on a stable surface. To concurrently increase activity of the pectoralis major and triceps brachii, adding unstable surfaces under hands during knee PU and standard PU is recommended.Systematic Review RegistrationPROSPERO, identifier CRD42021268465.
Case Report: Low-grade glioma with NF1 loss of function mimicking diffuse intrinsic pontine glioma
Authors: Bernstock Joshua D. , Karandikar Paramesh V. , Chen Jason A. , Seidlitz Jakob , Friedman Gregory K. , Meredith David M. , Liu Kevin X. , Haas-Kogan Daphne , Reardon David A. , Peruzzi Pier Paolo 
Published: May 2024

Intrinsic, expansile pontine tumors typically occur in the pediatric population. These tumors characteristically present as diffuse intrinsic pontine glioma (DIPG), which is now considered as diffuse midline glioma (DMG), H3K27-mutated of the pons. DIPG has limited treatment options and a poor prognosis, and the value of tissue diagnosis from an invasive biopsy remains controversial. This study presents the case of a 19-year-old female with clinical and imaging hallmarks of DIPG, who underwent a biopsy of a tumor in the region of the right middle cerebellar peduncle. Her lesional cells were negative for H3K27M alterations and had low-grade histologic features. Next-generation sequencing revealed a frameshift mutation in the NF1 gene as the likely driver mutation. These features suggest a diagnosis of a low-grade glioma associated with NF1 loss of function, with far-reaching consequences regarding both treatment strategy and prognosis. This case provides support for the utility of diagnostic tissue biopsy in cases of suspected DIPG.
CILEMBU SWEET POTATO (Ipomoea batatas) AND GARUT SWEET POTATO (Maranta arundinacea) AS A REPLACEMENT OF POTATO ON POTATO DEXTROSE AGAR TO GROWTH Candida albicans AND Trichophyton mentagrophytes
Authors: Dermawan Asep , Kurniati Iis , Marliana Nina 
Published: May 2024

Background : The media commonly used as fungal growth is Potato Dextrose Agar (PDA). PDA is media that contain carbohydrates from potatoes. Ubi Cilembu sweet potato (Ipomoea batatas) and Garut sweet potato (Maranta arudinacea) are plants with high carbohydrate content so that they can be used as an energy source for the growth of various types of fungi including pathogenic fungi. This study aims to analyze and determine the concentration of sweet potato flour sweet which can be used as a substitute medium for potatoes on PDA media for the growth of C. albicans and T.mentagrophytes optimally.
Method : The method used is an experiment with a completely randomized design. C. albicans and T.mentagrophytes are test fungi obtained from the Microbiology Laboratory of the Bandung Institute of Technology. Variations in concentration of sweet potato flour were made to 0.4%, 0.5%, 0.6% and 0.7% to obtain the most optimum concentration of Cilembu and Garut sweet potato flour for the growth of test fungi. Growth of C. albicans and T.mentagrophytes was seen visually in media with different types of sweet potatoes as a substitute for potatoes on PDA media as a control medium.
Result : The results showed that Cilembu and Garut sweet potato can optimally grow C. albicans and T.mentagrophytes. After testing Anova (α = 0.05) there were significant differences in the number and diameter of colonies on alternative media and control media. The medium of Garut sweet potato flour at a concentration of 0.7% grows the best test fungi.
Conclusion : The medium of Garut sweet potato flour at a concentration of 0.7% grows the best test fungi. Research on stability, sensitivity, and specificity needs to be done to determine Cilembu sweet potato and Garut sweet potato media as a valid alternative media for PDA.
Uses, Perceptions and Impacts of Instagram: A Study with Young Higher Education Students
Authors: Morais Salomé , Pereira Telma , Raposo Rui , Gouveia Teresa 
Published: May 2024

Given the evidence that young people have a very active presence on social networks, especially Instagram (Kemp, 2022), it is important to study this phenomenon and understand what drives young people to use this social network to share content, especially photos and audiovisual content. The study presented was guided by the following research questions: What is Instagram used for by university students? How does Instagram impact and influence youth perceptions regarding everyday life? From a methodological perspective, the case study resorted to a mixed methodology. Data was collected through a questionnaire and a focus group from undergraduate students from a public higher education institution in Portugal. The study collected data from 89 respondents, mostly female and aged between 19 and 22. The results revealed that Instagram is one of their favourite social networks and is where they spend the most time daily, mainly to keep in touch with friends and family and find new content. Participants affirmed that they don't use social media to feel accepted, validated or integrated. This shows that they use social media to reinforce what they already know and feel through the feedback they receive from shared content. Even though most state that they don't engage in getting likes, comments or reactions on their shared content, the participants in the study admit that this is a consequence and are happy with the feedback they receive. The study, although limited to a sample of students from a single higher education institution, enabled the researchers to understand better some engagement habits that currently take up little under one-fourth of the users’ daily time while awake. The sheer fact that users spend so much time on this social media platform daily, sometimes with little or no positive impact on other activities, has already been outlined as an issue worth tackling in future studies.
L’exemple historique au service de la persuasion complotiste. Une analyse rhétorique
Authors: Donckier de Donceel Lucie 
Published: May 2024

Le but de cet article est d’analyser l’usage de l’exemple historique comme procédé persuasif dans les discours complotistes, en contexte francophone, autour de la pandémie de covid-19. Le corpus étudié se compose d’un ensemble d’extraits de discours complotistes produits en ligne, il fait partie d’un plus vaste corpus de thèse, articulé autour des trois genres (délibératif, judiciaire et épidictique) de la rhétorique. Dans le corpus sélectionné, nous pensons que l’effet persuasif produit reposerait, notamment, sur la mobilisation d’un exemple historique paradigmatique pour nos sociétés – la Shoah – et sur la construction d’un ethos comme témoin. En nous appuyant sur une analyse rhétorique inspirée de la triade aristotélicienne des trois preuves (ethos, pathos et logos) et de plus récentes études en argumentation et analyse du discours, nous faisons l’hypothèse que la construction réciproque d’un ethos de témoin et le recours à l’exemple historique de la Shoah permettent aux orateurs complotistes de présenter des discours dont la force persuasive relève moins de l’argumentation factuelle que d’un effet d’évidence propre au témoignage.
Depth profiles of deep levels generated in the tail region of Al ion implantation into n-type 4H-SiC
Authors: Fujii Haruki , Kaneko Mitsuaki , Kimoto Tsunenobu 
Published: May 2024

Abstract
Depth profiles of deep levels in the tail region of Al ion implantation in n-type 4H-SiC were investigated by deep level transient spectroscopy measurements. Deep levels energetically located at E
c − 0.55 eV, E
c − 0.64 eV, and E
c − 1.50 eV (E
c: conduction band bottom) are generated in the tail region by the implantation and subsequent activation annealing at 1750 °C for 20 min. The densities of these defects were approximately 20–40 times lower than the implanted Al atom density, and the densities of these defects and Al atoms exhibited an exponential decay along the depth direction with a decay length of 140–190 nm. Another deep level located at E
c − 1.30 eV was detected in the tail region and the density of this trap decreased more rapidly with a decay length of 62 nm. The origins of the observed deep levels are discussed based on several experimental results.
UTILIZAÇÃO DE MÉTODOS OBJETIVOS E SUBJETIVOS PARA ESTABELECER O ESTADO NUTRICIONAL DE CRIANÇAS EM PRÉ-OPERATÓRIO DE CIRURGIA CARDÍACA, BELÉM - PA
Authors: Matos de Pinho Costa Priscila , Teixeira Prazeres Karen , Da Silva Rodrigues Kelly Bárbara , De Carvalho Oliveira Ariane , Raiol Barros Edson Raimundo , De Souza Torres Rosileide , Araújo Almeida Barbosa Socorro Nazaré , Gianne de LaRocque Barros Warken  , Marly Lobato Maciel  , Patrícia Bentes Diniz  , Kelly Layla da Silva Guterres  , Max Monteiro Costa  , Da Silva Gutteres Aldair 
Published: May 2024

Objetivo: utilizar métodos objetivos e subjetivos para estabelecer o estado nutricional de crianças em pré-operatório de cirurgia cardíaca. Métodos: Estudo transversal, realizado com crianças cardiopatas hospitalizadas, em pré-operatório de cirurgia cardíaca. Foi realizada avaliação antropométrica e avaliação subjetiva global (ASG). Resultados: A maioria das crianças cardiopatas eram do sexo feminino 57,45%, encontravam-se classificadas na fase pré-escolar, 38,30% e possuíam tetralogia de fallot, 29,79%. Quanto aos indicadores de antropométricos, constatou-se que a maioria apresentou os parâmetros em adequação. Entretanto, observou-se percentual considerável de desnutrição, pois 25,53% dos avaliados apresentam P/I e E/I classificados em baixo ou muito baixo e 23,40% apresentam IMC/I classificados em magreza ou magreza acentuada. Segundo a avaliação subjetiva global adaptada para o público pediátrico, constatou-se que a maioria, 74,47% estavam moderadamente desnutridas. Conclusão: Houve percentuais consideráveis de desnutrição em ambos os métodos utilizados, o que reflete maior segurança no uso desses métodos tanto isoladamente quanto em conjunto.
DIFICULDADES NO DIAGNÓSTICO PRECOCE DO AUTISMO
Authors: Fonseca Clementele Lilian , Pereira de Morais João Pedro , Nava Flores Kevillyn Maria , Araujo henrique Sandy hevelyn , Santos Maracaipe Mirielly , Diniz de Araújo Filho Josafá , Pessoa Cardoso Oliveira Beatriz , Rodrigues da Costa Souza Guilherme , Tadeu Tavares De Almeida Victor , Oliver de Assis Oliveira Geverson , Emanuel Dantas da Silva Diógenes , Bastos Venturim Thainá , Pereira Carneiro Heloísa , Henrique Silva de Sousa Kelven , Batista Cordeiro Amanda Luiza , Correa Dos Santos Reis Manuela , Bonato Jonas Felipe 
Published: May 2024

O transtorno do espectro autista (TEA) é caracterizado por uma série de condições relacionadas ao dano no desenvolvimento neurológico como comportamento repetitivo, comprometimento nas habilidades sociais, fala, e na comunicação não verbal. Assim, o diagnóstico precoce é de suma importância para a intervenção visando o desenvolvimento dos pacientes com TEA e o auxílio de seus familiares. O presente estudo busca destacar os critérios diagnósticos e a dificuldade para que tal diagnóstico seja realizado de forma precoce, além de salientar o principal manejo para tal transtorno.