bluuebunny/crossref_metadata_2025_split huggingface dataset:
FC10-04 - Efficacy of auditory stimulation programs for the treatment of depression, dysthymia and symptoms of burnout - RCT results
Authors: Brandes V.M. , Terris D.D. , Fischer C. , Loerbroks A. , Jarczok M.N. , Ottowitz G. , Titscher G. , Fischer J.E. , Thayer J.F. 
Published: May 2011

Depression is a prevalent, often chronic and disabling disease. Current psychosocial and antidepressant treatments result in similar response rates with mostly symptom reduction, but not complete remission. Poor treatment adherence complicates depression management and prevention of recurrent episodes. Therefore, new therapies must be developed urgently, that alone or combined with present treatments, can significantly improve therapy outcomes.Depression is potentially associated with decreased heart rate variability (HRV). Based on our previous studies' results which demonstrated HRV increase following auditory stimulation, we developed two interventions based on specifically for depression treatment composed and arranged music and tested the efficacy in a waiting list and placebo controlled double-blind study with depressed outpatients.Depression status was assessed at the beginning of T1 and T2 using the Hamilton Rating Scale for Depression (HAM-D), Beck Depression Inventory (BDI), Hospital Anxiety and Depression Scale (HADS-D) and by a composite (COMP) scale based on HAM-D, BDI and HADS-D z-scores. Changes in depressive symptoms between T1 and T2 (5 week period) were assessed based on COMP and on HAM-D, BDI and HADS-D scores alone. Compared to the control arm, a significant, positive effect in COMP was observed for MT1 at T2. Both MT1 and MT2 were associated with significant positive effects (HAM-D and HADS-D scores). MT2 resulted in positive effects on BDI scores. No significant change in any depression score was detected in the placebo arm. Treatment continuation was associated with an effect increase (mean HAM-D score reduction of 60%) after 10 to 15 weeks of treatment.
FC10-05 - Attenuated serotonin transporter association between midbrain and nucleus accumbens in major depression
Authors: Hahn A. , Akimova E. , Häusler D. , Philippe C. , Savli M. , Baldinger P. , Höflich A. , Zgud S. , Mitterhauser M. , Wadsak W. , Lanzenberger R. , Kasper S. 
Published: May 2011

IntroductionPatients suffering from major depressive disorder (MDD) exhibit alterations in serotonin transporter (5-HTT) binding clinically reflected by lack of hedonic experience. We recently demonstrated the importance to evaluate interregional relationships of neurotransmitter systems, providing important complementary information on a network level.ObjectiveTo identify interregional 5-HTT relationships between the midbrain raphe region and projection areas in MDD patients compared to controls.MethodsEighteen medication-free patients with MDD and 16 healthy subjects underwent PET using [11C] DASB. 5-HTT binding potential (BPND) maps were computed with the multilinear-reference-tissue-model-2 in PMOD3.1. Voxel-wise linear regression was calculated in SPM8 using midbrain 5-HTT BPND as regressor; group comparisons were assessed by ANOVA (p < 0.001).ResultsHealthy subjects showed positive associations between serotonin transporters located in the midbrain and transporters expressed in the nucleus accumbens bilaterally. Importantly, this relationship was significantly decreased in MDD patients as compared to controls (t = 5.41/4.84, right/left hemisphere; see figure).ConclusionsThis study demonstrates for the first time 5-HTT alterations on a network level in MDD patients between the midbrain and a major projection area. Our results complement previous findings emphasizing the importance of the nucleus accumbens in MDD and indicate a disturbed serotonergic regulation in this key area of reward processing.
FC11-01 - Depression prevalence and its relationship with delivery method in Iranian women
Authors: Zangene M. , Shams Alizadeh N. , Rezaei F. , Rezaei M. 
Published: May 2011

IntroductionPostpartum depression is the most common and major health problem affecting mother, newborn and family health.ObjectivesThis study aimed to determine depression prevalence and its relationship with delivery method in Iranian women.AimsTo identify factors contributing to postpartum depression.MethodsIn this cross-sectional study 531 primiparous women were evaluated 20 to 40 days after delivery. The instruments of gathering data were Edinburg Postpartum Depression Scale which were completed via interview. Analysis of data was performed by SSPS 12.0 software.ResultsIn total 40.7% of participants had postpartum depression. The depression rate among emergent caesarean, normal delivery and elective caesarean groups was 50%, 40.5% and 27% respectively. There was a significant relationship between delivery method and depression (P = 0.001). No significant relationship was found between postpartum depression with age and mother's education level.ConclusionIn this study the rate of depression in emergent caesarean group was greater than normal delivery and elective caesarean groups, therefore the method of delivery must be determined before delivery to decrease the rate of emergent caesarean by appropriate strategies. Furthermore, in emergent caesarean some interventions should be performed to decrease the rate of postpartum depression.
FC11-02 - The role premenstrual syndrome (PMS) and psychological variables in prediction of cesarean labor
Authors: Ghooshchianchoobmasjedi S. , Dehghani M. 
Published: May 2011

IntroductionPrevalence of the cesarean labor in Iran has reported 41percent in recent studies which is really higher than expected rate compare to other countries.ObjectivesOur purpose in this research was to examine the role of premenstrual syndrome (PMS) and psychological variables(Depression, Anxiety, Stress) in prediction of the cesarean labor.AimsMy aim was to examine the role of premenstrual syndrome and psychological variables(Depression, Anxiety, Stress) in prediction of the cesarean labor in Iran.MethodsParticipants were 300 pregnant women from two private (n = 150) and public (n = 150) hospitals who were selected using available sampling method. After informed consent provided from all participate, variables such as age, level of education, month of pregnancy, previous number of deliveries, previous number of cesarean, tendency to cesarean and type of hospital were control for using counter balancing method.Two questionnaires of Short Premenstrual Assessment Form (SPAF) and Depression, Anxiety, Stress Scale (DASS) were administrated.ResultsA Regression Binary Logistic was revealed that month of pregnancy, previous number of cesareans and also the type of hospital could predict the tendency to cesarean. No significant effect was observed for psychological variables (Depression, Anxiety, Stress) and premenstrual syndrome (PMS).ConclusionsThese results showed that increase in the month of pregnancy and also decrease in the previous number of cesareans and selection of private hospital, predict the cesarean delivery among women.
FC11-03 - Effectiveness of anger management training anger on the severity of symptoms premenstrual syndrome
Authors: Saleh Ahangar K. , Ahmadi Gatab T. 
Published: May 2011

IntroductionPremenstrual syndrome following repeated monthly collection of signs and symptoms of physical and psychological in the late luteal phase occurs.Aims/ methodsThis experimental research study design, pre-test - post test control group is. First 250 people in a community of women, the menstrual record daily symptoms for two consecutive months have been filled, then between them, the final sample (24 = n) on most women who have been signs of anger; established To determine the effectiveness of anger management anger on the severity of symptoms of premenstrual syndrome (PMS) is.has been.Groups includingGroup receiving 12 sessions of one and a half hours of anger management training and group not receiving training. Test 2 anger Ashpylbrgr for all participants (experimental and control) was performed.Results/ conclusions12 weekly sessions of anger management anger effectively PMS symptoms were reduced. No significant difference in the severity of PMS symptoms before and after the anger management training anger has been viewed.In this study, the fact that the anger of the symptoms of this syndrome are highlighted. The results indicated that the mean scores in anger before and after the intervention has been significant change. The positive effect of education on mental to control PMS symptoms is emphasized.
FC11-04 - Patterns of depression and trajectories of treatment over the perinatal period
Authors: Bowen A. , Bowen R. , Muhajarine N. 
Published: May 2011

IntroductionPerinatal depression is an important problem with potentially deleterious health outcomes; however, we know little about the trajectories of depression and treatment.PurposeWe report the patterns of maternal depression and trajectories of treatment response in early and late pregnancy and during postpartum in 649 women recruited from the general population of pregnant women in Western Canada. Women who scored ≥ 12 on the Edinburgh Postnatal Depression Scale were classified as depressed.FindingsFifty-two percent of participants were primiparas, 90% were partnered, 83.3% Caucasian, 67% earn more than $40,000 per year, 90% completed high school, and 77% had planned pregnancy. The unadjusted prevalence of depression in early pregnancy (17 weeks) was 14%, late pregnancy (30 weeks) 11.5%, and postpartum (4.1 weeks) was 9.8%. All of the psychosocial factors measured - history of depression, mood instability, lack of social support, relationship problems, worry, and stressors heighten depression symptoms throughout parturition. Our practice of referring women who screened positive for depression changed prevalence rates of women who were depressed and in treatment. The number of women in treatment increased from 12.2% in early pregnancy to 24.8% at postpartum. Women were significantly more likely to get symptom relief counselling in pregnancy compared to psychotropic medication use in postpartum, with the exception of those women with history of depression and treatment engagement.SummaryIncreased understanding of the patterns and nature of maternal depression and treatment response is essential to early identification of women who are depressed and lead to treatment that is more effective.
FC11-06 - Female - only psychiatric intensive care unit (PICU): Prospective study of patient demographics and outcomes at elizabeth casson house, bristol, UK
Authors: Gintalaite-Bieliauskiene K. , Tandon V. , Woochit V. 
Published: May 2011

IntroductionThere are above 170 PICUs identified in the UK. A modest body of research has emerged documenting characteristics of PICU populations. Comprehensive data describing patients admitted to PICUs remains incomplete. There is no data on Female only PICU population's characteristics.ObjectiveTo offer the first and the only project data country wide up to date on Female only PICU population. It describes socio-demographic characteristics, mental state and outcome of treatment for 49 patients admitted to the first Female PICU in NHS in UK in 2008MethodProspective case note analysisResults65% of patients were single, 73% were Caucasian and 26% had BME background. Most of patients were admitted from police stations and detained under S2 or S3 of the MHA. Most dominant diagnoses were Schizophrenia and Personality Disorder. 77% of admissions were due to physical aggression and severe self harm. Most patients had more than 5 previous admissions to Mental Health wards. Half of the patients received intramuscular Rapid Tranquilization during the admission and 22% were placed in Enhanced Care Area. Median length of stay did not exceed recommended 8 weeks but some patients with the diagnosis of Personality Disorder experienced an excessive length of PICU stay. Most patients were transferred to open acute wards.ConclusionsPatients admitted to Female PICU were most likely to have major psychosis or personality disorder, admitted due to violence or self harming behavior, more likely to exceed recommended max length of stay if diagnosis of PD was given, BME group being represented.
FC12-03 - DTI-based in vivo mapping of subregions within the human hypothalamus
Authors: Schoenknecht P. , Anwander A. , Petzold F. , Schindler S. , Knoesche T. , Hegerl U. , Turner R. , Geyer S. 
Published: May 2011

IntroductionThe hypothalamus is involved in many aspects of behavioral responses but parcellations of hypothalamic subnuclei have only been feasible in post-mortem brains. Thus it would be-from a clinical point of view-highly desirable if hypothalamic subnuclei could be delineated also noninvasively in living subjects. This study is a first step in this direction: We exploited the directionality information inherent in high-resolution DTI data to map subregions of the hypothalamus in healthy volunteers.directionality information using DTI data to map subregions of the hypothalamus.MethodsWe scanned 10 subjects with a Siemens 3 T scanner, acquired DTI and T1 scans. We computed the similarity of fiber orientations between all voxels and subjects, and clustered the similarity matrix in 3 regions using a k-means algorithm.ResultsThe diffusion images showed anisotropic tissue orientation within the hypothalamus which was consistent across subjects. The clustering in 3 regions resulted in an anatomically coherent arrangement of clusters across hemispheres and subjects. In each ROI, we found an anterior, a posteromedial, and a lateral subdivision with consistent microscopic tissue orientations across subjects.ConclusionThis is to our best knowledge the first study that demonstrates the fine-grained microstructural organization within the human hypothalamus noninvasively in living subjects.
FC12-04 - Striatal dopamine transporter (DAT) availability and affective symptoms in movement disorders: A 123I-FP-CIT spect study
Authors: Camardese G. , Di Giuda D. , Fasano A. , Cocciolillo F. , Bentivoglio A.R. , Bruno I. , Guidubaldi A. , De Risio L. , Pucci L. , Giordano A. , Bria P. , Janiri L. 
Published: May 2011

AimRecent studies suggest an association of affective symptoms with striatal dopaminergic activity in Parkinson's Disease (PD). On the other hand, the psychopathological features of other common Movement Disorders (MD), such as Essential Tremor (ET) and Primary Dystonia, are less explored.We investigated striatal dopamine transporter (DAT) availability and affective symptoms in these three different MD.Materials and methods22 pts with ET, 14 pts with focal dystonia and 34 idiopathic PD pts underwent 123I-FP-CIT SPECT. A control group of 15 healthy subjects was also analyzed.Psychiatric assessment included the HAM-D scale for severity of depression, the HAM-A scale for anxiety levels, the Snaith Hamilton Pleasure Scale (SHAPS) for anhedonia.SPECT was carried out 3 hours after 111 MBq 123I-FP-CIT intravenous injection. Specific 123I-FP-CIT binding in the striatum and striatal subregions was calculated based on ROI analysis.ResultsSignificant reduction of 123I-FP-CIT binding ratios was found only in PD. Spearman's analysis showed an inverse correlation between anxiety and DAT availability in the left striatal regions of both ET and dystonic patients. On the contrary, a significant positive correlation was found in PD subjects.ConclusionThis preliminary study provided evidence for an association between pre-synaptic striatal dopaminergic function of the left hemisphere and anxiety in MD, thus confirming the “transnosologic” relevance of dopaminergic dysfunction.Unexpected findings in PD patients are in contrast with previous results. A down-regulation of DAT could be hypothesized in both ET and dystonic patients. This pattern seems to be concordant with preliminary findings in primary anxiety disorders.
FC12-06 - On the relevance of comorbidity in psychiatry: EEG loreta in generalized anxiety disorder with and without nonorganic Insomnia
Authors: Saletu-Zyhlarz G. , Anderer P. , Saletu B. 
Published: May 2011

IntroductionComorbidity is increasingly regarded as important for both diagnosis and treatment of psychiatric disorders.ObjectivesElectrophysiological neuroimaging such as low-resolution brain electromagnetic tomography (LORETA) may be utilized to obtain insight into the pathogenesis of mental diseases.AimsThe aim of the present study was to compare EEG tomographic data obtained in generalized anxiety disorder (GAD) with and without nonorganic insomnia.MethodsIn the first study, LORETA was performed in 44 untreated patients (25 females) with the primary diagnosis of nonorganic insomnia (F51.0) associated with GAD (F41.1) and 44 age- and sex-matched normal controls. In the second study, 18 patients (9 females) with the primary diagnosis of GAD without mandatory insomnia were compared with 18 controls.ResultsWhile patients with F51.0 and concomitant F41.1 showed an increase in LORETA power in the delta, theta, alpha-1 and alpha-2 frequencies, GAD patients without mandatory insomnia demonstrated a decrease in LORETA power - specifically in delta (more left than right hemisphere, involving occipital cortex, insula, cingulate and frontal cortex) and beta (occipital cortex), mirroring neuroimaging findings on the neural circuitry of anxiety.ConclusionsDifferent EEG LORETA findings were obtained in GAD patients, depending on the comorbidity: While in daytime recordings patients with nonorganic insomnia demonstrated increased slow activities reflecting daytime tiredness and sleepiness, GAD patients without insomnia exhibited a decrease in slow activity and thus hypervigilance. According to the key-lock principle different pharmacological strategies have to be applied, which will be demonstrated on the basis our own data sets.
FC13-01 - Dialectical behavior therapy-based skills training for family members of suicide attempters
Authors: Rajalin M. , Jokinen J. 
Published: May 2011

A suicide attempt is a challenge both for the patient and for family members. Family members of suicide victims have an increased risk for depression and anxiety. This pilot study evaluated the effect of Family Connections (FC), a Dialectical Behavior Therapy-based manualized skills training program, for family members of suicide attempters. The DBT-based skills training program aims to enhance the knowledge of wide range research based aspects of suicidal behavior and treatment recommendations. Furthermore it includes skills training for interpersonal relationships and also offers family members an opportunity to share their experiences.Thirteen participants completed the 9-week program with pre- and post selfreport questionnaires. The results showed significant reduction in Burden Assessment Scale (BAS) and in three out of four subscales of Questions about Family Members (QAFM):perceived criticism (PC), critical comments (CC), and emotional over involvement (EOI).These results provide support for the need and importance of a DBT-based skills training program addressed specifically to family members of suicide attempters.
FC13-04 - Suicide risk in relation to age and psychiatric hospitalization
Authors: Reutfors J. , Brandt L. , Sparring Björkstén K. , Ekbom A. , Ösby U. 
Published: May 2011

IntroductionSuicide risk is increased in patients with a history of psychiatric hospitalization.AimTo explore how suicide risk varies by age during psychiatric hospitalization and in the year post-discharge.MethodsThis is a population-based case-control study of all suicides (n = 20,675; 70% male) in Sweden aged ≥18 years during 1991–2003. Each suicide was individually matched to 10 population controls by age, sex, and county of residence. Discharge diagnoses of a mental disorder (except dementia and other organic disorders) in the year prior to suicide were identified by register linkage. Odds ratios (OR) were calculated by conditional logistic regression to estimate the relative risk of suicide in those with psychiatric diagnoses compared to the general population. ORs were estimated by age group (18–34 years, 35–49 years, 50–64 years, and ≥ 65 years) and timing of the suicide in relation to discharge.ResultsDuring hospitalization, the youngest age group had the greatest suicide risk elevation [OR 64 (95% CI 44-92)]. In the first month post-discharge, the oldest age group had the highest suicide risk elevation [OR 162 (95% 66–399) in the first week and OR 127 (95% 67–242) in the second to fourth weeks]. In the remaining eleven months, suicide risk elevation was lower and relatively similar in different age groups.ConclusionsDuring the year following psychiatric hospitalization, an especially high attention should be paid to the suicide risk of the elderly patients in the first month post-discharge.
FC13-07 - The review of relapse after discontinuation of naltrexone
Authors: Tatari F. , Torkamani F. , Abdoli G. , Nasiri A. , Qhelichi L. 
Published: May 2011

IntroductionIn recent years, both abstinence- and harm-reduction strategies for managing opium dependency are being generalized. In those who use detoxification, maintenance therapy with Naltrexone, an opioid antagonist protects them against relapse. This is important to know the best time of Naltrexone discontinuation to lower the risk of relapse.ObjectionThis study tried to determine the efficacy of Naltrexone in prevention of opioid relapse and the factors interfere to the outcome.Material and method150 opium addicts who were admitted in Kermanshah Rehabilitation Centre for Naltrexone maintenance therapy contributed in this 18 month length study. They received Naltrexone for 6 months and followed then after for another 12 months. Opium test (TLC) were done monthly in the first 6 months, and then in 3 month intervals for 12 subsequent months to find out the relapse.Results1)The relapse rates were 56.7%(85) after 6-month, and 4.7%(7)after one-year.2)The succession rate was 38.6%(58).3)The lowest succession rate was in 18–25 year old, The highest was in 35–40 year old adults(10).4)In person with diploma and higher the succession rate(43.8%) was higher than poor educated(34.7%) ones.5)The succession rate was higher in those who: were employee(72.7%), were addicted to heroin(44.9%), didn’t have positive family history(41.3%), and had more incomes(46.7%).Discussion1)In those who the relapse is delayed until 9 months after detoxification, the chance of long term abstinence is higher.2)The employees and those who have more social disciplines are more successful in ceasing opium abuse.
FC13-08 - Not polypharmacy, just symptomatic treatment
Authors: Launer M. ,   Kemple View Psychiatric Services
Published: May 2011

The concept of polypharmacy has generated much argument and this is has now come to a head with specific symposia and now a CINP thematic meeting. Briefly, those in academia, pharmacy and general adult practice tend to frown on this whereas the forensic members rely on it. Steven Stahl has even famously called it “the dirty little secret”.More recently the concept of rational polypharmacy has arisen where the clicinician can justify his prescriptions. All of this depends on treating a named condition eg schizophrenia. Indeed affective disorders are often treated with polypharmacy and many physical conditions are routinely given polypharmacy.If we assume that Kraepelin was wrong about his original assertion that there is a schism and whether other conditions are also not proven like personality disorders, then patients can simply be treated by their symptoms without a diagnosis. There are many advantages to this like the abolition of stigma but more importantly this allows the use of traditional drugs used for other conditions like lithium or anti manic agents to be used as required according to response rather than for specific diagnoses. There are other advantages eg in research and especially genetics.The presentation examines this in detail with some real life examples.