bluuebunny/crossref_metadata_2025_split huggingface dataset:
Matrix metalloproteinase‐7 as a marker of metastasis and predictor of poor survival in bladder cancer
Authors: Szarvas Tibor , Becker Markus , Vom Dorp Frank , Gethmann Carolin , Tötsch Martin , Bánkfalvi Ágnes , Schmid Kurt W. , Romics Imre , Rübben Herbert , Ergün Süleyman 
Published: January 2010

Matrix metalloproteinases (MMPs) play an important role in tumor progression and metastasis. Here, we investigated the prognostic relevance of MMP‐7 in urinary bladder cancer. MMP‐7 gene expression was measured in tissue samples of 101 patients using quantitative real‐time PCR. Circulating MMP‐7 serum levels of 98 individuals (79 patients and 19 controls) were analyzed by enzyme‐linked immunosorbent assay. The results were compared with the clinical follow‐up data, performing Kaplan–Meier log‐rank test as well as univariate and multivariate Cox analysis. In representative cases, immunohistochemical analysis for MMP‐7 was performed. We detected significantly elevated MMP‐7 levels both in tissue and serum samples of patients with metastatic disease (P = 0.001 and P = 0.002). Multivariate analysis revealed that high MMP‐7 tissue expression and serum concentration are stage‐ and grade‐independent predictors of both metastasis‐free (hazard ratio [HR] = 3.80, 95% confidence interval [CI], 1.29–11.23, P = 0.016, and HR = 2.53, 95% CI, 1.01–6.37, P = 0.048) and disease‐specific survival (HR = 1.89, 95% CI, 1.00–3.55, P = 0.050 and HR = 1.95, 95% CI, 1.03–3.71, P = 0.041). Based on these findings, we conclude that MMP‐7 is a promising marker to detect present and to predict future metastasis. Serum MMP‐7 analysis provides information about the risk of metastasis before surgery which could help to optimize therapeutic procedures. Furthermore, high MMP‐7 tissue and/or serum levels could identify patients most likely to benefit from early adjuvant chemotherapy.(Cancer Sci 2010; 101: 1300–1308)
Mapping QTL for growth and shank traits in chickens divergently selected for high or low body weight
Authors: Ankra‐Badu G. A. , Bihan‐Duval E. Le , Mignon‐Grasteau S. , Pitel F. , Beaumont C. , Duclos M. J. , Simon J. , Carré W. , Porter T. E. , Vignal A. , Cogburn L. A. , Aggrey S. E. 
Published: January 2010

SummaryAn F2population (695 individuals) was established from broiler chickens divergently selected for either high (HG) or low (LG) growth, and used to localize QTL for developmental changes in body weight (BW), shank length (SL9) and shank diameter (SD9) at 9 weeks. QTL mapping revealed three genome‐wide QTL on chromosomes (GGA) 2, 4 and 26 and three suggestive QTL on GGA 1, 3 and 5. Most of the BW QTL individually explained 2–5% of the phenotypic variance. The BW QTL on GGA2 explained about 7% of BW from 3 to 7 weeks of age, while that on GGA4 explained 15% of BW from 5 to 9 weeks. The BW QTL on GGA2 and GGA4 could be associated with early and late growth respectively. The GGA4 QTL also had the largest effect on SL9 and SD9 and explained 7% and 10% of their phenotypic variances respectively. However, when SL9 and SD9 were corrected with BW9, a shank length percent QTL was identified on GGA2. We identified novel QTL and also confirmed previously identified loci in other chicken populations. As the foundation population was established from commercial broiler strains, it is possible that QTL identified in this study could still be segregating in commercial strains.
Epidemiology of paediatric invasive fungal infections and a case‐control study of risk factors in acute leukaemia or post stem cell transplant
Authors: Hale Katherine A. , Shaw Peter J. , Dalla‐Pozza Luciano , MacIntyre Chandini Raina , Isaacs David , Sorrell Tania C. 
Published: January 2010

SummaryPatients aged 0–18 years with confirmed or possible invasive fungal infection were identified by medical record and database searches. Cases with an underlying diagnosis of acute leukaemia or following stem cell transplantation were included in a case control study. Controls included all other children with acute leukaemia or stem cell transplant in the corresponding time period. Variables collected included demographics, underlying disease risk and status, organ impairment, admission to intensive care unit, fungal infection details and certain transplant variables. Risk factors for development of invasive fungal infection were examined using logistic regression. There were 106 cases of invasive fungal infection during the study. The incidence of invasive fungal infection was 21% in acute lymphoblastic leukaemia, 15% in acute myeloid leukaemia and 25% following stem cell transplantation. Sixty per cent were neutropenic at diagnosis and 39% had concomitant bacteremia. High risk acute lymphoblastic leukaemia, relapsed disease, intensive care admission and graft‐versus‐host disease were significantly associated with development of invasive fungal infection on multivariate analysis. These associations provide new information on paediatric invasive fungal infections and warrant further study; caution should be encouraged when extrapolating from adult studies.
Strong seasonal disequilibrium measured between the oxygen isotope signals of leaf and soil CO2 exchange
Authors: WINGATE LISA , OGÉE JÉRÔME , BURLETT RÉGIS , BOSC ALEXANDRE 
Published: January 2010

AbstractThe oxygen isotope composition (δ18O) of atmospheric CO2 is among a very limited number of tools available to constrain estimates of the biospheric gross CO2 fluxes, photosynthesis and respiration at large scales. However, the accuracy of the partitioning strongly depends on the extent of isotopic disequilibrium between the signals carried by these two gross fluxes. Chamber‐based field measurements of total CO2 and CO18O fluxes from foliage and soil can help evaluate and refine our models of isotopic fractionation by plants and soils and validate the extent and pattern of isotopic disequilibrium within terrestrial ecosystems. Owing to sampling limitations in the past, such measurements have been very rare and covered only a few days. In this study, we coupled automated branch and soil chambers with tuneable diode laser absorption spectroscopy techniques to continuously capture the δ18O signals of foliage and soil CO2 exchange in a Pinus pinaster Aït forest in France. Over the growing season, we observed a seasonally persistent isotopic disequilibrium between the δ18O signatures of net CO2 fluxes from leaves and soils, except during rain events when the isotopic imbalance became temporarily weaker. Variations in the δ18O of CO2 exchanged between leaves, soil and the atmosphere were well explained by theory describing changes in the oxygen isotope composition of ecosystem water pools in response to changes in leaf transpiration and soil evaporation.
Evaluation of enteric methane prediction equations for dairy cows used in whole farm models
Authors: ELLIS J. L. , BANNINK A. , FRANCE J. , KEBREAB E. , DIJKSTRA J. 
Published: January 2010

AbstractThe importance of evaluating greenhouse gas (GHG) emissions from dairy cows within the whole farm setting is being realized as more important than evaluating these emissions in isolation. Current whole farm models aimed at evaluating GHG emissions make use of simple regression equations to predict enteric methane (CH4) production. The objective of the current paper is to evaluate the performance of nine CH4 prediction equations that are currently being used in whole farm GHG models. Data used to evaluate the prediction equations came from a collection of individual (IND) and treatment averaged (TRT) data. Equations were compared based on mean square prediction error (MSPE) and concordance correlation coefficient (CCC) analysis. In general, predictions were poor, with root MSPE (as a percentage of observed mean) values ranging from 20.2 to 52.5 for the IND database and from 24.0 to 38.2 for the TRT database and CCC values ranging from 0.009 to 0.493 for the IND database and from 0.000 to 0.271 for the TRT database. Overall, the equations of Moe & Tyrrell and IPCC Tier II performed best on the IND dataset, and the equations of Moe & Tyrrell and Kirchgeßner et al., performed best on the TRT dataset. Results show that the simple more generalized equations performed worse than those that attempted to represent important aspects of diet composition, but in general significant amounts of bias and deviation of the regression slope from unity existed for all equations. The low prediction accuracy of CH4 equations in whole farm models may introduce substantial error into inventories of GHG emissions and lead to incorrect mitigation recommendations.
Embedded academic writing support for nursing students with English as a second language
Authors: Salamonson Yenna , Koch Jane , Weaver Roslyn , Everett Bronwyn , Jackson Debra 
Published: January 2010

salamonson y., koch j., weaver r., everett b. & jackson d. (2010) Embedded academic writing support for nursing students with English as a second language. Journal of Advanced Nursing66(2), 413–421.AbstractTitle.  Embedded academic writing support for nursing students with English as a second language Aim.  This paper reports a study which evaluated a brief, embedded academic support workshop as a strategy for improving academic writing skills in first‐year nursing students with low‐to‐medium English language proficiency.Background.  Nursing students who speak English as a second language have lower academic success compared with their native English‐speaking counterparts. The development of academic writing skills is known to be most effective when embedded into discipline‐specific curricula.Methods.  Using a randomized controlled design, in 2008 106 students pre‐enrolled in an introductory bioscience subject were randomized to receive either the intervention, a 4‐day embedded academic learning support workshop facilitated by two bioscience (content) nursing academics and a writing and editing professional, or to act as the control group. The primary focus of the workshop was to support students to work through a mock assignment by providing progressive feedback and written suggestions on how to improve their answers.Results.  Of the 59 students randomized to the intervention, only 28 attended the workshop. Bioscience assignment results were analysed for those who attended (attendees), those randomized to the intervention but who did not attend (non‐attendees), and the control group. Using anova, the results indicated that attendees achieved statistically significantly higher mean scores (70·8, sd: 6·1) compared to both control group (58·4, sd: 3·4, P = 0·002) and non‐attendees (48·5, sd: 5·5, P = 0·001).Conclusion.  A brief, intensive, embedded academic support workshop was effective in improving the academic writing ability of nursing students with low‐to‐medium English language proficiency, although reaching all students who are likely to benefit from this intervention remains a challenge.
Optimizing HIV care by expanding the nursing role: patient and provider perspectives
Authors: Chen Wei‐Ti , Shiu Cheng‐Shi , Simoni Jane , Fredriksen‐Goldsen Karen , Zhang Fujie , Zhao Hongxin 
Published: January 2010

chen w.‐t., shiu c.‐s., simoni j., fredriksen‐goldsen k., zhang f. & zhao h. (2010) Optimizing HIV care by expanding the nursing role: patient and provider perspectives. Journal of Advanced Nursing 66(2), 260–268.AbstractTitle.  Optimizing HIV care by expanding the nursing role: patient and provider perspectives. Aim.  This paper is a report of a study conducted to explore HIV healthcare services from the perspectives of both healthcare providers and patients in order to understand how to optimize HIV nursing care.Background.  In China, healthcare providers usually first diagnose HIV in a general hospital. Then, HIV‐positive individuals are transferred to a specialist hospital. Between healthcare providers and healthcare institutions, there are many gaps in the process from diagnosis to treatment.Methods.  One focus group with six healthcare providers and 29 in‐depth interviews with people living with HIV/AIDS were conducted during 2005.Findings.  Patients who were diagnosed with HIV in a general hospital often did not discuss their condition with a healthcare provider before being sent to a specialist hospital. Furthermore, since the patients had already been diagnosed, healthcare providers in the specialist hospital did not deal adequately with the disclosure process and emotional reactions to the diagnosis. They reported feeling overwhelmed in their role in providing healthcare services. Nurses reported that they were responsible for many ‘non‐nursing’ tasks and did not have the opportunity to give the type of care they were trained to offer.Conclusion.  Optimizing HIV care in China will involve establishing clear boundaries between general and specialist hospitals and a division of labour among healthcare providers that eases the burden of care and takes advantage of the full scope of practice that nurses are trained to provide.
Experiences of postpartum depression among first‐time mothers in mainland China
Authors: Gao Ling‐ling , Chan Sally Wai‐chi , You Liming , Li Xiaomao 
Published: January 2010

gao l.‐l., chan s.w.‐c., you l. & li x. (2010) Experiences of postpartum depression among first‐time mothers in mainland China. Journal of Advanced Nursing 66(2), 303–312.AbstractTitle.  Experiences of postpartum depression among first‐time mothers in mainland China. Aim.  This paper is a report of a study conducted to describe the experience of postpartum depression among first‐time mothers in mainland China.Background.  Postpartum depression affects approximately 10–20% of women across many different cultural settings; however, most theories of this condition have been developed in Western societies. Transcultural studies may enhance the understanding of the sociocultural factors associated with postpartum depression.Method.  A phenomenological approach was used. Data were collected through in‐depth interviews from January to June 2008. A purposive sample was recruited from a postnatal clinic at a regional hospital in mainland China. Fifteen first‐time mothers who scored 13 or above on the Edinburgh Postnatal Depression Scale at 6 weeks after childbirth were interviewed.Findings.  Three themes were identified: feeling drained, perceiving oneself to be a failure and dissonance. Women felt physically and emotionally exhausted. They perceived themselves to be incompetent and imperfect mothers, and thus, failures. They experienced dissonance between tradition and modernity and between expectations and reality. The practice of ‘doing the month’, daughter‐in‐law/mother‐in‐law relationship, gender of the baby and one‐child policy contributed to their depression.Conclusion.  Cultural values need to be taken into account in order better to understand the causes, prevention, and diagnosis of postpartum depression, and care provision for women with this condition. Perinatal education could aim at improving a woman’s resilience by enhancing her problem‐solving ability and cognitive restructuring skills. Further studies could be carried out in other parts of China or other Asian countries to determine the transferability of the findings.
Critical thinking as an outcome of a Master’s degree in Nursing programme
Authors: Drennan Jonathan 
Published: January 2010

drennan j. (2010) Critical thinking as an outcome of a Master’s degree in Nursing programme. Journal of Advanced Nursing66(2), 422–431.AbstractTitle.  Critical thinking as an outcome of a Master’s degree in Nursing programme Aim.  This paper is a report of a study measuring critical thinking ability in graduates on completion of a Master’s degree in Nursing.Background.  Nurse education programmes identify the development of critical thinking capabilities as a central outcome for graduates at Master’s level. However, despite the centrality of critical thinking to educational curricula, achievement of this outcome has not been evaluated.Method.  A cross‐sectional cohort study was conducted in Ireland between 2006 and 2007. Critical thinking was measured using the Watson–Glaser Critical Thinking Appraisal tool. The sample consisted of two cohorts: a control cohort (110 students commencing Master’s in Nursing programmes) and an outcome cohort (222 students who had a Master’s degree in Nursing). The Watson–Glaser Critical Thinking Appraisal scores of the graduate cohort were also compared to previously published norm reference scores in the area of nursing and other higher education professional groups.Results.  Graduates had statistically significantly higher critical thinking scores than commencing graduates. Graduates from Master’s in Nursing programmes also had similar critical thinking scores to nurses at undergraduate and postgraduate levels in the United States of America. However, scores were lower than those of occupational and academic groups in education and medicine.Conclusion.  Graduates from a Master’s degree in Nursing make statistically significant gains in critical thinking scores when compared to students commencing the programme. However, the gains were relatively modest and call into question the effectiveness of pedagogical methods used to facilitate the development of critical thinking at Master’s level.
Establishing contact and gaining trust: an exploratory study of care avoidance
Authors: Schout Gert , De Jong Gideon , Zeelen Jacques 
Published: January 2010

schout g., de jong g. & zeelen j. (2010) Establishing contact and gaining trust: an exploratory study of care avoidance. Journal of Advanced Nursing 66(2), 324–333.AbstractTitle.  Establishing contact and gaining trust: an exploratory study of care avoidance. Aim.  This paper is a report of a study conducted to explore the competencies – especially deep‐rooted personal qualities – of care providers who succeed in making contact and gaining trust with clients who are inclined to avoid the care they need.Background.  Demands, thresholds and fragmentation of services hinder the accessibility of health care, such that some severe mentally ill people do not receive the treatment they need or avoid healthcare services. Methods of establishing contact and gaining trust in mental health care include practical assistance, realistic expectations, establishing long‐term goals, empathy and a client‐centred and flexible approach.Method.  A public mental healthcare practice in The Netherlands with outstanding performance was studied from 2002–2007 using participant observation, interviews with experienced care providers and interviews with clients with a long history of avoiding care facilities, conflicts and troubled relationships with care providers.Findings.  A number of personal qualities are vital for establishing contact and gaining trust with these clients: altruism, a degree of compassion, loyalty, involvement, tenacity, a critical attitude to the mainstream, flexibility, optimism, diplomacy, patience, creativity, and a certain degree of immunity to stress.Conclusion.  Care providers who establish contact and win trust employ ‘non‐judgemental appreciation’. They start from the acceptance of what is and try to connect with the client and their world. These professionals use their initial actions to identify and praise qualities and achievements of clients. This style of work is supported by a set of deep‐rooted personal qualities we can summarize as ‘empathy’.
Evaluation of dental hygiene education for nursing home staff
Authors: Sjögren Petteri , Kullberg Erika , Hoogstraate Janet , Johansson Olle , Herbst Bertil , Forsell Marianne 
Published: January 2010

sjögren p., kullberg e., hoogstraate j., johansson o., herbst b. & forsell m. (2010) Evaluation of dental hygiene education for nursing home staff. Journal of Advanced Nursing 66(2), 345–349.AbstractTitle.  Evaluation of dental hygiene education for nursing home staff. Aim.  This paper is a report of a study evaluating the long‐term effects on the oral hygiene status of older nursing home residents one and a half years after dental hygiene education was given to the staff.Background.  A strong relationship exists between oral infections and general health complications (especially aspiration pneumonia) among nursing home residents and hospitalized older people. It is therefore important to educate nursing home staff in oral hygiene measures and to follow up the effects of the education over time.Methods.  Dental plaque measurements were conducted at a Swedish nursing home in 2006–2008. Forty‐one residents (12 men, 31 women, aged 69–99 years) fulfilled the inclusion criteria and participated in a dental hygiene evaluation 1·5 years after dental hygiene education was given to the staff at the nursing home. Plaque index scores (year 2008) were compared to those soon after the education (year 2006).Findings.  After the dental hygiene education in 2006, 60 nursing home residents (14 men, 46 women) were available for plaque index measurements, whereas 41 residents (12 men, 29 women) were available 1·5 years later. The median plaque index scores were 17·0 (n = 60) in 2006, and 18·0 (n = 41) in 2008 (Mann–Whitney U‐test, P > 0·05).Conclusion.  Dental hygiene education for nursing home staff is important to maintain an adequate level of oral hygiene among older nursing home residents over time. Follow‐up of dental hygiene education for nursing home staff is recommended to maintain a sufficient level of oral hygiene among the residents.
Helping parents cope with crying babies: decision‐making and interaction at NHS Direct
Authors: Smith Suzanne 
Published: January 2010

smith s. (2010) Helping parents cope with crying babies: decision‐making and interaction at NHS Direct. Journal of Advanced Nursing66(2), 381–391.AbstractTitle.  Helping parents cope with crying babies: decision‐making and interaction at NHS Direct. Aim.  This paper is a report of a study of how nurses at a national telephone triage centre in England (NHS Direct) make different use of the algorithms and organizational protocols to make decisions and give advice to parents with crying babies, how their clinical knowledge and experience influences these decisions, and the techniques used to enhance parental coping ability.Background.  Parents of persistently crying babies state that they need to be listened to, understood, believed and reassured to help them cope. Nurses at NHS Direct use their clinical judgement in decision‐making, and see the software as a guide that can be both valuable and problematic.Method.  The study design was influenced by grounded theory and incorporated discourse and thematic analysis. It had two phases involving data collection and analysis over the period 2002–2006. A theoretical sample of 11 calls was analysed and later a focus group of six nurses at the same site.Findings.  NHS Direct nurses used the ‘crying baby’ algorithm in various ways, influenced by their experience and confidence to use the algorithm to support their clinical knowledge. Its medical elements were regarded as safe but its non‐medical elements, including questions about the likelihood of shaking a child, were treated differently.Conclusion.  Nurses were reluctant to deviate from the algorithm when dealing with child‐focused calls. However, this reluctance did not apply when they were prompted to ask the caller if they felt that they were reaching a point where they might shake their baby, or when prompted to give related advice.