bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of transforming growth factor‐β1 antisense oligonucleotides on matrix metalloproteinases and their inhibitors in keloid fibroblasts
Authors: Bran Gregor M. , Goessler Ulrich R. , Baftiri Ariton , Hormann Karl , Riedel Frank , Sadick Haneen 
Published: June 2010

ObjectiveTo identify changes in the expression of matrixmetalloproteinases (MMPs) and their specific inhibitors tissue inhibitors of metalloproteinases (TIMPs) after targeting of transforming growth factor‐β1 (TGF‐β1) with antisense oligonucleotides.Study DesignCross‐sectional study.SettingThe study was performed on tissue samples from nine patients with keloid scars after otoplasty presenting to the Otolaryngology–Head and Neck Surgery Department of the University Hospital in Mannheim, Germany.Subjects and MethodsKeloid fibroblasts and normal fibroblasts were harvested from auricular keloid scars and healthy skin regions of the same patients during resection procedure of the keloid. Cells were placed in monolayer cultures. Expression of MMPs and TIMPs were analyzed by immunohistochemistry. The effect of TGF‐β1 targeting using antisense oligonucleotides on the expression of both protein groups in keloid‐derived fibroblasts was analyzed by enzyme‐linked immunosorbent assay and reverse‐transcription polymerase chain reaction.ResultsImmunohistochemical investigation demonstrated increased expression of MMP‐2, ‐3, ‐9, and ‐13 and TIMP‐1 and ‐2. TGF‐β1 antisense therapy significantly down‐regulated MMP secretion in vitro.ConclusionUsage of TGF‐β1 antisense oligodeoxynucleotides (ODNs) may show a potential chemopreventive or therapeutic option for keloids by blocking the effect of TGF‐β1. Furthermore, antisense ODNs can be used as an investigative approach toward a better understanding of molecular mechanisms in keloid pathophysiology.
Clinical consensus statement: Diagnosis and management of nasal valve compromise
Authors: Rhee John S. , Weaver Edward M. , Park Stephen S. , Baker Shan R. , Hilger Peter A. , Kriet J. David , Murakami Craig , Senior Brent A. , Rosenfeld Richard M. , DiVittorio Danielle 
Published: June 2010

ObjectiveTo create a clinical consensus statement to address ambiguities and disparities in the diagnosis and management of nasal valve compromise (NVC).Subjects and MethodsAn updated systematic review of the literature was conducted. In addition, a Modified Delphi Method was used to refine expert opinion and facilitate a consensus position.ResultsAfter two rounds of surveys and conference calls, 36 items reached consensus, six items reached near consensus, and 10 items reached no consensus. The categories that had the greatest percentage of consensus or near consensus items were as follows: definition, history and physical examination, outcome measures, and management. Conversely, the categories with greater percentage of no consensus items were adjunctive tests and coding.ConclusionThe consensus panel agreed that NVC is a distinct clinical entity that is best evaluated with history and physical examination findings. Endoscopy and photography are useful but not routinely indicated, whereas radiographic studies are not useful in evaluating NVC. Other objective nasal outcome measures may not be useful or accepted for NVC. Nasal steroid medication is not useful for treatment of NVC in the absence of rhinitis, and mechanical treatments may be useful in selected patients. Surgical treatment is the primary mode of treatment of NVC, but bill coding remains ambiguous and confusing.
Systematics and molecular phylogeny of two African stem borer genera,SciomesaTams & Bowden andCarelisBowden (Lepidoptera: Noctuidae)
Authors: Moyal P. , Le Ru B. , Conlong D. , Cugala D. , Defabachew B. , Matama-Kauma T. , Pallangyo B. , Van den Berg J. 
Published: June 2010

AbstractCurrently, the systematics of the African noctuid stem borers of the subtribe Sesamiina, which include major pests of cereals, is confused. In addition, their ecology is poorly known, as are the factors influencing their evolution. In this paper, we address these shortcomings for two genera of the Sesamiina,SciomesaTams & Bowden andCarelisBowden. Mixed Bayesian phylogenetic analysis, which included their host plants and two mitochondrial genes, showed the genusSciomesato be polyphyletic. Two new genera were created,PirateoleaandFeraxinia. The genusCarelisproved to be paraphyletic and was subdivided into two sub-genera. The generaSciomesa,CarelisandPirateolea(named the ‘Sciomesagenus group’) share morphological traits, and the phylogenetic analysis showed that they had a common ancestor living on Cyperaceae and that they were distant from the genusFeraxiniabelonging to another clade which had an ancestor living on Poaceae. Seven new species were described:Sciomesa gnosiasp. n.,Sciomesia buasp. n.,Pirateolea nolagen. n, sp. n.,Feraxinia serenagen. n., sp. n.,Carelis australissp. n.,Carelis transversasp. n. andCarelis agnaesp. n. Ten species were sunk as synonyms:Sciomesa mesoscia(Hampson) syn. n.,Sciomesa mirificaLaporte syn. n.,Sciomesa constantiniLaporte syn. n. andSciomesa etchecopariLaporte syn. n. are synonyms ofSciomesa mesophaea(Aurivillius);Acrapex sparsipuctaLaporte syn. n. is a synonym ofSciomesa excelsa(Laporte) comb. n.;Acrapex congitaeLaporte syn. n.,Sesamia minutaLaporte syn. n. andSesamia minusculaLaporte syn. n. are synonyms ofSciomesa boulardi(Laporte) comb. n.;Acrapex bryaeLaporte syn. n. andAcrapex fayeiLaporte syn. n. are synonyms ofFeraxinia jemjemensis(Laporte) comb. n. Eleven new combinations were created:Sciomesa excelsa(Laporte) comb. n.,Sciomesa boulardi(Laporte) comb. n.,Sciomesa punctipennis(Krüger) comb. n.,Pirateolea piscator(Fletcher) comb. n.,Pirateolea argocyma(Fletcher) comb. n.,Pirateolea cyclophora(Fletcher) comb. n.,Pirateolea ochroneura(Fletcher) comb. n.,Pirateolea funebris(Krüger) comb. n.,Feraxinia nyei(Fletcher) comb. n.,Feraxinia jemjemensis(Laporte) comb. n. andCarelis biluma(Nye) comb. n.
ON THE OSOFSKY–SMITH THEOREM
Authors: CRIVEI SEPTIMIU , NĂSTĂSESCU CONSTANTIN , TORRECILLAS BLAS 
Published: June 2010

AbstractWe recall a version of the Osofsky–Smith theorem in the context of a Grothendieck category and derive several consequences of this result. For example, it is deduced that every locally finitely generated Grothendieck category with a family of completely injective finitely generated generators is semi-simple. We also discuss the torsion-theoretic version of the classical Osofsky theorem which characterizes semi-simple rings as those rings whose every cyclic module is injective.
ACTIONS OF LIE SUPERALGEBRAS ON SEMIPRIME ALGEBRAS WITH CENTRAL INVARIANTS
Authors: GRZESZCZUK PIOTR , HRYNIEWICKA MAŁGORZATA 
Published: June 2010

AbstractLet R be a semiprime algebra over a field of characteristic zero acted finitely on by a finite-dimensional Lie superalgebra L = L0 ⊕ L1. It is shown that if L is nilpotent, [L0, L1] = 0 and the subalgebra of invariants RL is central, then the action of L0 on R is trivial and R satisfies the standard polynomial identity of degree 2 ⋅ [$\sqrt{2^{\dim_{\mathbb{K}}L_1}}$]. Examples of actions of nilpotent Lie superalgebras, with central invariants and with [L0, L1] ≠ 0, are constructed.
ALMOST-PERFECT MODULES
Authors: AYDOĞDU PINAR , ÖZCAN A. ÇIĞDEM 
Published: June 2010

AbstractWe call a module Malmost perfect if every M-generated flat module is M-projective. Any perfect module is almost perfect. We characterize almost-perfect modules and investigate some of their properties. It is proved that a ring R is a left almost-perfect ring if and only if every finitely generated left R-module is almost perfect. R is left perfect if and only if every (projective) left R-module is almost perfect.
Lazzari felici: Neapolitan song and/as nostalgia
Authors: PLASTINO GOFFREDO 
Published: June 2010

AbstractAlthough the canzone napoletana (Neapolitan song) is the best-known Italian popular music in the world, it is also the most misunderstood. It is mostly associated with operatic or quasi-operatic vocal styles, but all the other Neapolitan popular voices, the performance features and even the history of this musical genre are less well known. This essay in particular considers how the porous Neapolitan voice is a ‘space’ for complex negotiations between different musical styles, and how through this voice (that admits within itself the existence of other vocal styles) Neapolitan composers, musicians and singers articulate different relationships between music, history and nostalgia.
PrevalentLq-dimensions of measures
Authors: OLSEN L. 
Published: June 2010

AbstractLetKbe a compact subset of ℝdand writesfor the Hausdorff dimension ofK. For a probability measure μ onK, the lower and upperLq-dimensions of orderq∈ ℝ are defined byIn this paper we studyLq-dimensions of measures that are generic in the sense of prevalence. In particular, we prove that ifKsatisfies a mild regularity condition, then a prevalent probability measure μ onKsatisfies:for all 0 ≤q≤ 1, andfor all 1 ≤q. This result is in sharp contrast to the behaviour of theLq-dimensions of measures that are generic in the sense of Baire category. Namely, ifKsatisfies a mild regularity condition, then a probability measure μ onKthat is generic in the sense of Baire category satisfies:for all 1 <q.
Environmental heterogeneity of World Wildlife Fund for Nature ecoregions and implications for conservation in Neotropical biodiversity hotspots
Authors: LONDOÑO-MURCIA MARÍA CECILIA , TELLEZ-VALDÉS OSWALDO , SÁNCHEZ-CORDERO VÍCTOR 
Published: June 2010

SUMMARYMesoamerica, Chocó and the tropical Andes are recognized as biodiversity hotspots where conservation action is urgently needed. Because World Wildlife Fund for Nature (WWF) ecoregions are commonly used as the basis for conservation decisions, an understanding of WWF ecoregions’ environmental heterogeneity and their representation in current protected areas (PAs) is important for identifying priority areas for conservation. Thirteen environmental domain classifications based on 22 climatic and topographical variables and the Shannon diversity index were used to quantify environmental diversity for each WWF ecoregion. The area of each environmental domain and ecoregion was compared with the World Database on Protected Areas 2007. The most environmentally-diverse ecoregions were poorly represented in the PAs and several ecoregions showed low environmental heterogeneity representation inside PAs, for example the Balsas depression, Sierra Madre del Sur and the Chiapas Sierras in Mexico, some sierras in Central America, the Middle Magdalena, inter-Andean valleys, the Eastern Cordillera of Colombia and the Western Moist Forest of Ecuador. Using WWF ecoregions as equivalent units for conservation and management can be misleading, given their environmental heterogeneity; therefore, they have limited usefulness in assessing environmental representation in PAs. An underestimation of environmental heterogeneity representation in PAs can have misleading implications for conservation actions in regions where detailed biological information is lacking. Conservation efforts should focus on the environmental domains and ecoregions showing high environmental heterogeneity that is poorly represented in PAs.
Relations among maternal socialization, effortful control, and maladjustment in early childhood
Authors: Eisenberg Nancy , Spinrad Tracy L. , Eggum Natalie D. , Silva Kassondra M. , Reiser Mark , Hofer Claire , Smith Cynthia L. , Gaertner Bridget M. , Kupfer Anne , Popp Tierney , Michalik Nicole 
Published: June 2010

AbstractIn a sample of 18-, 30-, and 42-month-olds, the relations among parenting, effortful control (EC), and maladjustment were examined. Parenting was assessed with mothers' reports and observations; EC was measured with mothers' and caregivers' reports, as well as a behavioral task; and externalizing and internalizing symptoms were assessed with parents' and caregivers' reports. Although 18-month unsupportive (vs. supportive) parenting negatively predicted EC at 30 months, when the stability of these variables was taken into account, there was no evidence of additional potentially causal relations between these two constructs. Although EC was negatively related to both internalizing and externalizing problems within all three ages as well as across 1 year, EC did not predict maladjustment once the stability of the constructs and within time covariation between the constructs were taken into account. In addition, externalizing problems at 30 months negatively predicted EC at 42 months, and internalizing problems at 30 months positively predicted EC at 42 months, but only when the effects of externalizing on EC were controlled. The findings are discussed in terms of the reasons for the lack of causal relations over time.
Developmental cascades of peer rejection, social information processing biases, and aggression during middle childhood
Authors: Lansford Jennifer E. , Malone Patrick S. , Dodge Kenneth A. , Pettit Gregory S. , Bates John E. 
Published: June 2010

AbstractThis study tested a developmental cascade model of peer rejection, social information processing (SIP), and aggression using data from 585 children assessed at 12 time points from kindergarten through Grade 3. Peer rejection had direct effects on subsequent SIP problems and aggression. SIP had direct effects on subsequent peer rejection and aggression. Aggression had direct effects on subsequent peer rejection. Each construct also had indirect effects on each of the other constructs. These findings advance the literature beyond a simple mediation approach by demonstrating how each construct effects changes in the others in a snowballing cycle over time. The progressions of SIP problems and aggression cascaded through lower liking, and both better SIP skills and lower aggression facilitated the progress of social preference. Findings are discussed in terms of the dynamic, developmental relations among social environments, cognitions, and behavioral adjustment.
Developmental cascades: Externalizing, internalizing, and academic competence from middle childhood to early adolescence
Authors: Moilanen Kristin L. , Shaw Daniel S. , Maxwell Kari L. 
Published: June 2010

AbstractThe current study was initiated to increase understanding of developmental cascades in childhood in a sample of at-risk boys (N= 291; 52% White). Mothers, teachers, and boys reported on boys' externalizing problems, internalizing difficulties, and academic competence. Consistent with hypotheses regarding school-related transitions, high levels of externalizing problems were associated with both low levels of academic competence and high levels of internalizing problems during the early school-age period, and with elevations in internalizing problems during the transition to adolescence. Low levels of academic competence were associated with high levels of internalizing problems in middle childhood, and with high levels of externalizing problems during the transition from elementary school to middle school. Shared risk factors played a minimal role in these developmental cascades. Results suggest that there are cascading effects of externalizing problems and academic competence in childhood and early adolescence, and that some cascading effects are more likely to occur during periods of school-related transitions. Implications of developmental cascade effects for research and intervention are discussed.
A cascade model connecting life stress to risk behavior among rural African American emerging adults
Authors: Brody Gene H. , Chen Yi-Fu , Kogan Steven M. 
Published: June 2010

AbstractA three-wave cascade model linking life stress to increases in risk behavior was tested with 347 African American emerging adults living in the rural South. Data analyses using structural equation modeling and latent growth curve modeling demonstrated that life stress was linked to increases in risk behavior as African Americans transitioned out of secondary school. The cascade model indicated that life stress fostered increases in negative emotions. Negative emotions, in turn, were linked to increases in affiliations with deviant peers and romantic partners; this forecast increases in risk behavior. The findings supported a stress proliferation framework, in which primary stressors affect increases in secondary stressors that carry forward to influence changes in risk behaviors that can potentially compromise mental health.
Household and local forest impacts of Morocco's argan oil bonanza
Authors: LYBBERT TRAVIS J. , MAGNAN NICHOLAS , ABOUDRARE ABDELLAH 
Published: June 2010

ABSTRACTMorocco's argan oil is now the most expensive edible oil in the world. Growing high-value argan markets have sparked a bonanza of argan activity. NGOs, international and domestic development agencies, and argan oil cooperatives have promoted the win–win aim of simultaneously benefiting locals and the argan forest. We test this win–win claim by surveying households before and after rapid appreciation in argan prices. The argan boom has benefited some rural households. Those well positioned to benefit increased their goat herds more than other households, which bodes poorly for forest impacts, and were more likely to send their girls to secondary school. While locals are keeping their goats out of argan trees during the harvest, they may also be resorting to more aggressive harvesting techniques. The boom has made households vigilant guardians of fruit on their own trees, but has not incited investments in longer term tree and forest health.
Survival of Escherichia coli in the environment: fundamental and public health aspects
Authors: van Elsas Jan Dirk , Semenov Alexander V , Costa Rodrigo , Trevors Jack T 
Published: June 2010

Abstract
In this review, our current understanding of the species Escherichia coli and its persistence in the open environment is examined. E. coli consists of six different subgroups, which are separable by genomic analyses. Strains within each subgroup occupy various ecological niches, and can be broadly characterized by either commensalistic or different pathogenic behaviour. In relevant cases, genomic islands can be pinpointed that underpin the behaviour. Thus, genomic islands of, on the one hand, broad environmental significance, and, on the other hand, virulence, are highlighted in the context of E. coli survival in its niches. A focus is further placed on experimental studies on the survival of the different types of E. coli in soil, manure and water. Overall, the data suggest that E. coli can persist, for varying periods of time, in such terrestrial and aquatic habitats. In particular, the considerable persistence of the pathogenic E. coli O157:H7 is of importance, as its acid tolerance may be expected to confer a fitness asset in the more acidic environments. In this context, the extent to which E. coli interacts with its human/animal host and the organism's survivability in natural environments are compared. In addition, the effect of the diversity and community structure of the indigenous microbiota on the fate of invading E. coli populations in the open environment is discussed. Such a relationship is of importance to our knowledge of both public and environmental health.
Succession of methanotrophs in oxygen–methane counter-gradients of flooded rice paddies
Authors: Krause Sascha , Lüke Claudia , Frenzel Peter 
Published: June 2010

Abstract
Little is known about population dynamics and contribution of specific taxa to methane oxidation in flooded rice paddies. In this article we investigate the succession of methanotrophs in oxygen–methane counter-gradients. We used a gradient microcosm system that simulates oxic–anoxic interfaces of a water-saturated paddy soils, and measured pmoA-based (gene encoding particulate methane monooxygenase) terminal restriction fragment length polymorphism (T-RFLP) profiles at both the transcription (mRNA) and the population (DNA) levels. The DNA T-RFLP profiles indicated that the methanotrophic community present clearly differed from the active methanotrophic community. We observed a succession of the methanotrophic community over time without any direct effect of pore water chemistry on the community structure. Both the total population and the active subpopulation changed with time, whereas methane oxidation rates remained nearly constant. Hence, we suggest that a diverse microbial seed bank of methanotrophs is important in maintaining the function in a dynamic ecosystem.
Interaction of iron regulatory protein-1 (IRP-1) with ATP/ADP maintains a non-IRE-binding state
Authors: Popovic Zvezdana , Templeton Douglas M. 
Published: June 2010

In its aconitase-inactive form, IRP-1 (iron regulatory protein-1)/cytosolic aconitase binds to the IRE (iron-responsive element) of several mRNAs to effect post-transcriptional regulation. We have shown previously that IRP-1 has ATPase activity and that binding of ATP suppresses the IRP-1/IRE interaction. In the present study, we characterize the binding activity further. Binding is observed with both [α-32P]ATP and [α-32P]ADP, but not with [γ-32P]ATP. Recombinant IRP-1 binds approximately two molecules of ATP, and positive co-operativity is observed with a Hill coefficient of 1.67±0.36 (EC50=44 μM) commencing at 1 μM ATP. Similar characteristics are observed with both apoprotein and the aconitase form. On binding, ATP is hydrolysed to ADP, and similar binding parameters and co-operativity are seen with ADP, suggesting that ATP hydrolysis is not rate limiting in product formation. The non-hydrolysable analogue AMP-PNP (adenosine 5′-[β,γ-imido]triphosphate) does not induce co-operativity. Upon incubation of IRP-1 with increasing concentrations of ATP or ADP, the protein migrates more slowly on agarose gel electrophoresis, and there is a shift in the CD spectrum. In this new state, adenosine nucleotide binding is competed for by other nucleotides (CTP, GTP and AMP-PNP), although ATP and ADP, but not the other nucleotides, partially stabilize the protein against spontaneous loss of aconitase activity when incubated at 37 °C. A mutant IRP-1(C437S) lacking aconitase activity shows only one ATP-binding site and lacks co-operativity. It has increased IRE-binding capacity and lower ATPase activity (Km=75±17 nmol/min per mg of protein) compared with the wild-type protein (Km=147±48 nmol/min per mg of protein). Under normal cellular conditions, it is predicted that ATP/ADP will maintain IRP-1 in a non-IRE-binding state.
Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases IIα and IIβ and a partial nuclear localization of the IIα isoform
Authors: Wang Minchuan , Bond Nicholas J. , Letcher Andrew J. , Richardson Jonathan P. , Lilley Kathryn S. , Irvine Robin F. , Clarke Jonathan H. 
Published: June 2010

PtdIns5P 4-kinases IIα and IIβ are cytosolic and nuclear respectively when transfected into cells, including DT40 cells [Richardson, Wang, Clarke, Patel and Irvine (2007) Cell. Signalling 19, 1309–1314]. In the present study we have genomically tagged both type II PtdIns5P 4-kinase isoforms in DT40 cells. Immunoprecipitation of either isoform from tagged cells, followed by MS, revealed that they are associated directly with each other, probably by heterodimerization. We quantified the cellular levels of the type II PtdIns5P 4-kinase mRNAs by real-time quantitative PCR and the absolute amount of each isoform in immunoprecipitates by MS using selective reaction monitoring with 14N,13C-labelled internal standard peptides. The results suggest that the dimerization is complete and random, governed solely by the relative concentrations of the two isoforms. Whereas PtdIns5P 4-kinase IIβ is &gt;95% nuclear, as expected, the distribution of PtdIns4P 4-kinase IIα is 60% cytoplasmic (all bound to membranes) and 40% nuclear. In vitro, PtdIns5P 4-kinase IIα was 2000-fold more active as a PtdIns5P 4-kinase than the IIβ isoform. Overall the results suggest a function of PtdIns5P 4-kinase IIβ may be to target the more active IIα isoform into the nucleus.