bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase 2 results from Radiation Therapy Oncology Group Study 0537
Authors: Wong Raimond K. W. , James Jennifer L. , Sagar Stephen , Wyatt Gwen , Nguyen‐Tân Phuc Felix , Singh Anurag K. , Lukaszczyk Barbara , Cardinale Francis , Yeh Alexander M. , Berk Lawrence 
Published: January 2012

AbstractBACKGROUND:In this phase 2 component of a multi‐institutional, phase 2/3, randomized trial, the authors assessed the feasibility and preliminary efficacy of acupuncture‐like transcutaneous electrical nerve stimulation (ALTENS) in reducing radiation‐induced xerostomia.METHODS:Patients with cancer of the head and neck who were 3 to 24 months from completing radiotherapy with or without chemotherapy (RT ± C) and who were experiencing xerostomia symptoms with basal whole saliva production ≥0.1 mL per minute and were without recurrence were eligible. Patients received twice weekly ALTENS sessions (24 sessions over 12 weeks) using a proprietary electrical stimulation unit. The primary study objective was to assess the feasibility of ALTENS treatment. Patients were considered compliant if 19 of 24 ALTENS sessions were delivered, and the targeted compliance rate was 85%. Secondary objectives measured treatment‐related toxicities and the effect of ALTENS on overall radiation‐induced xerostomia burden using the University of Michigan Xerostomia‐Related Quality of Life Scale (XeQOLS).RESULTS:Of 48 accrued patients, 47 were evaluable. The median age was 60 years, 84% of patients were men, 70% completed RT ± C for >12 months, and 21% had previously received pilocarpine. Thirty‐four patients completed all 24 ALTENS sessions, 9 patients completed 20 to 23 sessions, and 1 patient completed 19 sessions, representing a 94% total compliance rate. Six‐month XeQOLS scores were available for 35 patients and indicated that 30 patients (86%) achieved a positive treatment response with a mean ± standard deviation reduction of 35.9% ± 36.1%. Five patients developed grade 1 or 2 gastrointestinal toxicity, and 1 had a grade 1 pain event.CONCLUSIONS:The current results indicated that ALTENS treatment for radiation‐induced xerostomia can be delivered uniformly in a cooperative, multicenter setting and produces possible beneficial treatment response. Given these results, the phase 3 component of this study was initiated. Cancer 2012. © 2011 American Cancer Society.
Outcome for adolescent and young adult patients with osteosarcoma
Authors: Janeway Katherine A. , Barkauskas Donald A. , Krailo Mark D. , Meyers Paul A. , Schwartz Cindy L. , Ebb David H. , Seibel Nita L. , Grier Holcombe E. , Gorlick Richard , Marina Neyssa 
Published: January 2012

AbstractBACKGROUND:There are conflicting data regarding age as a prognostic factor in osteosarcoma. The authors conducted a study evaluating the impact of age on prognosis in children and young adults with osteosarcoma enrolled on North American cooperative group trials.METHODS:Patients with high‐grade osteosarcoma of any site enrolled on North American cooperative group trials CCG‐7943, POG‐9754, INT‐0133, and AOST0121 were included in this study. Primary tumor site, age, sex, ethnicity, histologic response, and presence of metastatic disease at diagnosis were evaluated for their impact on overall survival (OS) and event‐free survival (EFS).RESULTS:A total of 1054 patients were eligible and had complete data available for the study. Age was not significantly associated with any other presenting covariate analyzed except sex. Age 18 or older was associated with a statistically significant poorer EFS (P = .019) and OS (P = .043). The 10‐year EFS and OS in patients <10, 10 to 17, and ≥18 years old were 55%, 55%, 37% and 68%, 60%, 41%, respectively. The poorer EFS in patients ≥18 years old was because of an increased rate of relapse. Presence of metastatic disease at diagnosis, poor histologic response, and pelvic tumor site were also associated with a poorer prognosis. In multivariate analysis, age continued to be associated with poorer EFS (P = .019) and OS (P = .049).CONCLUSIONS:In osteosarcoma, age 18 to 30 years is associated with a statistically significant poorer outcome because of an increased rate of relapse. Poorer outcome in adolescent and young adult patients is not explained by tumor location, histologic response, or metastatic disease at presentation. Cancer 2012. © 2012 American Cancer Society.
Aberrant DNA methylation of tumor‐related genes in oral rinse
Authors: Nagata Satoshi , Hamada Tomofumi , Yamada Norishige , Yokoyama Seiya , Kitamoto Sho , Kanmura Yuji , Nomura Masahiro , Kamikawa Yoshiaki , Yonezawa Suguru , Sugihara Kazumasa 
Published: January 2012

AbstractBACKGROUND:The early detection of oral squamous cell carcinoma (OSCC) is important, and a screening test with high sensitivity and specificity is urgently needed. Therefore, in this study, the authors investigated the methylation status of tumor‐related genes with the objective of establishing a noninvasive method for the detection of OSCC.METHODS:Oral rinse samples were obtained from 34 patients with OSCC and from 24 healthy individuals (controls). The methylation status of 13 genes was determined by using methylation‐specific polymerase chain reaction analysis and was quantified using a microchip electrophoresis system. Promoter methylation in each participant was screened by receiver operating characteristic analysis, and the utility of each gene's methylation status, alone and in combination with other genes, was evaluated as a tool for oral cancer detection.RESULTS:Eight of the 13 genes had significantly higher levels of DNA methylation in samples from patients with OSCC than in controls. The genes E‐cadherin (ECAD), transmembrane protein with epidermal growth factor‐like and 2 follistatin‐like domains 2 (TMEFF2), retinoic acid receptor beta (RARβ), and O‐6 methylguanine DNA methyltransferase (MGMT) had high sensitivity (>75%) and specificity for the detection of oral cancer. OSCC was detected with 100% sensitivity and 87.5% specificity using a combination of ECAD, TMEFF2, RARβ, and MGMT and with 97.1% sensitivity and 91.7% specificity using a combination of ECAD, TMEFF2, and MGMT.CONCLUSIONS:The aberrant methylation of a combination of marker genes present in oral rinse samples was used to detect OSCC with >90% sensitivity and specificity. The detection of methylated marker genes from oral rinse samples has great potential for the noninvasive detection of OSCC. Cancer 2012. © 2012 American Cancer Society.
A randomized study comparing yttrium‐90 ibritumomab tiuxetan (Zevalin) and high‐dose BEAM chemotherapy versus BEAM alone as the conditioning regimen before autologous stem cell transplantation in patients with aggressive lymphoma
Authors: Shimoni Avichai , Avivi Irit , Rowe Jacob M. , Yeshurun Moshe , Levi Itai , Or Reuven , Patachenko Paulina , Avigdor Abraham , Zwas Tzila , Nagler Arnon 
Published: January 2012

AbstractBACKGROUND:High‐dose chemotherapy combined with autologous stem‐cell transplantation (ASCT) is the standard therapy for refractory/relapsed aggressive lymphoma. In the era of rituximab‐containing frontline regimens, it is becoming more challenging to salvage patients in this setting, and novel approaches are required. This is a randomized study evaluating the safety and efficacy of standard‐dose ibritumomab tiuxetan (Zevalin) combined with high‐dose BEAM chemotherapy (Z‐BEAM) and ASCT in refractory/relapsed aggressive lymphoma.METHODS:Forty‐three patients with CD20+‐aggressive lymphoma were randomized to a treatment arm (Z‐BEAM, n = 22) or control arm (BEAM alone, n = 21). Ibritumomab tiuxetan was given at 0.4 mCi/kg on day −14 before ASCT.RESULTS:Patient characteristics, engraftment kinetics, and toxicity profile were similar between the 2 groups. Two‐year progression‐free survival (PFS) for all patients was 48% (95% confidence interval, 32%‐64%): 59% and 37% after Z‐BEAM and BEAM alone, respectively (P= .2). Multivariate analysis identified advanced age (hazard ratio [HR], 8.3;P= .001), high‐risk disease (relapse within 12 months of diagnosis and/or secondary International Prognostic Index >2; HR, 2.8;P= .04), positive positron emission tomography‐computed tomography pretransplant (HR, 2.4;P= .07), and BEAM alone (HR, 2.8;P= .03) as poor prognostic factors. Intermediate‐risk patients with 1 or 2 risk factors had better PFS with Z‐BEAM compared with BEAM: 69% and 29%, respectively (P= .07). Two‐year overall survival was 91% and 62% after Z‐BEAM and BEAM, respectively (P= .05). Similar prognostic factors determined survival. The HR for BEAM alone in the multivariate analysis was 8.1 (P= .01).CONCLUSIONS:Standard‐dose ibritumomab tiuxetan combined with BEAM high‐dose chemotherapy is safe and possibly more effective than BEAM alone as a conditioning regimen for ASCT in the era of rituximab‐containing chemotherapy regimens. Cancer 2012. © 2012 American Cancer Society.
A population‐based study of therapy and survival for patients with head and neck cancer treated in the community
Authors: Dansky Ullmann Claudio , Harlan Linda C. , Shavers Vickie L. , Stevens Jennifer L. 
Published: January 2012

AbstractBACKGROUND:The objective of this study was to examine patterns of care and survival in a population‐based sample of patients with head and neck cancer (HNC) who were treated in the community or in hospitals that had residency training programs.METHODS:Data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program were used to sample 1317 patients aged ≥20 years with invasive squamous HNC who were diagnosed during 2004 and who had vital status available through 2008.RESULTS:Treatment and survival were influenced by tumor site and disease stage. Patients who had stage I/II cancer of the oral cavity generally underwent surgery; patients with stage III oral cavity disease underwent surgery and received radiation; and patients with stage IV oral cavity disease underwent surgery and received chemoradiation. Patients with early stage cancer of the oropharynx either underwent surgery or received radiation and chemotherapy, and patients with late/unstaged oropharyngeal disease primarily received radiation and chemotherapy. Patients with early stage cancer of the larynx mainly received radiation alone, and patients with late stage laryngeal disease generally received chemoradiation. Cisplatin‐based regimens were used most frequently. Overall, taxanes were used in 32% of regimens, and cetuximab was used in <3% of regimens. Patients aged ≥50 years, those with a Charlson comorbidity score ≥1, those with stage IV disease, and those with cancer located in the oral cavity or larynx had poorer survival. Although facilities with residency training programs treated more black patients and more patients with late stage disease, when adjusted for other factors, survival rates were similar to those reported in facilities with no such programs.CONCLUSIONS:Therapy generally followed accepted standards for 2004. Findings in particular tumor sites and stages may reflect the variability that still exists for the treatment of HNC. The use of taxanes and cetuximab is expected to increase based on new evidence of benefit. Reducing treatment‐related toxicities and long‐term functional deficits will be critical and especially important with the increase in human papillomavirus‐related cancers. In addition, further attempts to improve survival for older patients are needed. Cancer 2012. © 2012 American Cancer Society.
Predicting survival of patients with hypocellular myelodysplastic syndrome
Authors: Tong Wei‐Gang , Quintás‐Cardama Alfonso , Kadia Tapan , Borthakur Gautam , Jabbour Elias , Ravandi Farhad , Faderl Stefan , Wierda William , Pierce Sherry , Shan Jianqin , Bueso‐Ramos Carlos , Kantarjian Hagop , Garcia‐Manero Guillermo 
Published: January 2012

AbstractBACKGROUND:Although most patients with myelodysplastic syndrome (MDS) exhibit bone marrow hypercellularity, a subset of them present with a hypocellular bone marrow. Specific factors associated with poor prognosis have not been investigated in patients with hypocellular MDS.METHODS:The authors studied a cohort of 253 patients with hypocellular MDS diagnosed at The University of Texas MD Anderson Cancer Center between 1993 and 2007 and a cohort of 1725 patients with hyper‐/normocellular MDS diagnosed during the same time period.RESULTS:Patients with hypocellular MDS presented more frequently with thrombocytopenia (P < .019), neutropenia (P < .001), low serum β‐2 microglobulin (P < .001), increased transfusion dependency (P < .001), and intermediate‐2/high‐risk disease (57% vs 42%, P = .02) compared with patients with hyper‐/normocellular MDS. However, no difference in overall survival was observed between the 2 groups (P = .28). Multivariate analysis identified poor performance status (Eastern Cooperative Oncology Group ≥2), low hemoglobin (<10 g/dL), unfavorable cytogenetics (−7/7q or complex), increased bone marrow blasts (≥5%), and high serum lactate dehydrogenase (>600 IU/L) as adverse independent factors for survival.CONCLUSIONS:A new prognostic model based on these factors was built that segregated patients into 3 distinct risk categories independent of International Prognostic Scoring System (IPSS) score. This model is independent from the IPSS, further refines IPSS‐based prognostication, and may be used to develop of risk‐adapted therapeutic approaches for patients with hypocellular MDS. Cancer 2012. © 2012 American Cancer Society.
Comparison of Low‐Frequency Spectra between Aromatic and Nonaromatic Cation Based Ionic Liquids Using Femtosecond Raman‐Induced Kerr Effect Spectroscopy
Authors: Shirota Hideaki 
Published: January 2012

AbstractIn this minireview, the features of low‐frequency spectra within the frequency range 0–200 cm−1 for aromatic and nonaromatic cation based ionic liquids obtained by femtosecond Raman‐induced Kerr effect spectroscopy are reviewed. For aromatic cation based ionic liquids, the aromatic group of the cations is largely responsible for the spectral line shape due to their larger polarizability anisotropy volume and more polarizable nature than nonaromatic cations. The low‐frequency Kerr spectra are also compared with the bulk properties of the ionic liquids. The differences in the relationship of the first moment of the low‐frequency spectrum band and the bulk properties between the aromatic and nonaromatic cation based ionic liquids with respect to the natures of constituent ions and microscopic aspects are discussed. For aromatic cation based ionic liquids, the ionic region is more pronounced than the nonpolar region in their low‐frequency Kerr spectra. In contrast, the ionic and nonpolar regions of nonaromatic cation based ionic liquids are likely to be captured due to the weaker signal of the cationic region. Also, the low‐frequency Kerr spectra of the nonaromatic analogues are influenced by their weaker segregation as compared to aromatic cation based ionic liquids.
Running throughout middle‐age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice
Authors: Marlatt Michael W. , Potter Michelle C. , Lucassen Paul J. , van Praag Henriette 
Published: January 2012

AbstractAge‐related memory loss is considered to commence at middle‐age and coincides with reduced adult hippocampal neurogenesis and neurotrophin levels. Consistent physical activity at midlife may preserve brain‐derived neurotrophic factor (BDNF) levels, new cell genesis, and learning. In the present study, 9‐month‐old female C57Bl/6J mice were housed with or without a running wheel and injected with bromodeoxyuridine (BrdU) to label newborn cells. Morris water maze learning, open field activity and rotarod behavior were tested 1 and 6 months after exercise onset. Here we show that long‐term running improved retention of spatial memory and modestly enhanced rotarod performance at 15 months of age. Both hippocampal neurogenesis and mature BDNF peptide levels were elevated after long‐term running. Thus, regular exercise from the onset and during middle‐age may maintain brain function. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 943–952, 2012
Distribution of amphipods (Gammarus nipponensisUeno) among mountain headwater streams with different legacies of debris flow occurrence
Authors: Kobayashi Sohei , Gomi Takashi , Sidle Roy C. , Negishi Junjiro N. 
Published: January 2012

ABSTRACTTo understand the impacts of debris flows on the distribution of an amphipod with limited dispersal ability in the context of stream networks, we surveyed the presence ofGammarus nipponensisin 87 headwater streams with different legacies of debris flow occurrence within an 8.5‐km2mountain catchment. The amphipod was present in only 7% of the streams impacted by debris flows after 1977; in contrast, it was present in 69% of the streams that had older or no debris flow occurrence. The absence of the amphipod in certain headwater streams did not appear to be related to water chemistry because pH and calcium concentrations differed little among streams within the catchment. In addition, survival rates of individuals incubated in streams with the amphipod present and absent did not differ significantly. Debris flows appeared to displace amphipod populations, and the absence of amphipods in streams for more than 30 years after debris flow occurrence suggests that considerable time is required for the recovery of populations. Because of geographic isolation from the source of colonists, headwater streams in the uppermost sections of the catchment and those indirectly connecting to the main stream via tributaries appear to be at greater disadvantage for receiving colonists from other areas and thus population recovery. Copyright © 2012 John Wiley & Sons, Ltd.
From cryptic chromosomal lesions to pathologically relevant genes: Integration of SNP‐array with gene expression profiling in myelodysplastic syndrome with normal karyotype
Authors: Merkerova Michaela Dostalova , Bystricka Dagmar , Belickova Monika , Krejcik Zdenek , Zemanova Zuzana , Polak Jaroslav , Hajkova Hana , Brezinova Jana , Michalova Kyra , Cermak Jaroslav 
Published: January 2012

AbstractMyelodysplastic syndrome (MDS), a clonal disorder originating from hematopoietic stem cell, is characterized by a progressive character often leading to transformation to acute myeloid leukemia. We used single nucleotide polymorphism arrays (SNP‐A) to identify previously cryptic chromosomal abnormalities such as copy number alterations and uniparental disomies (UPD) in cytogenetically normal MDS. In the aberrant regions, we attempted to localize candidate genes with potential relevance to the disease. Using SNP‐A, we analyzed peripheral blood granulocytes from 37 MDS patients. The analysis identified 13 cryptic chromosomal defects in 10 patients (27%). Four UPD (affecting chromosomes 3q, 7q, 17q, and 20p), 5 deletions and 4 duplications were detected. Gene expression data measured on CD34+ cells were available for 4 patients with and 6 patients without SNP‐A lesions. We performed an integrative analysis of genotyping and gene expression microarrays and found several genes with an altered expression located in the aberrant regions. The expression microarrays suggested BMP2 and TRIB3 located in 20p UPD as potential candidate genes contributing to MDS. We showed that the genome‐wide integrative approach is beneficial to the comprehension of molecular backgrounds of diseases with incompletely understood etiopathology. © 2012 Wiley Periodicals, Inc.
The prevalence of depressive symptoms among the older in China: a meta‐analysis
Authors: Zhang Ling , Xu Yong , Nie Hongwei , Zhang Yaodong , Wu Yan 
Published: January 2012

BackgroundThis study aims to find the status and prevalence of depressive symptoms among the population aged 60 years and above in China.MethodsWe conducted a meta‐analysis of cross‐sectional studies in older population. Epidemiological studies on depressive symptoms published in Chinese journals were identified manually and online by using the Chinese Biological Medical Literature Database, Chongqing VIP database for Chinese Technical Periodicals, and Chinese National Knowledge Infrastructure database. Studies published in English journals were identified using Medlars Online.ResultsA total of 32 eligible studies were included in this review. The analysis showed that the pooled prevalence (with 95% confidence interval) of depressive symptoms for the seniors in China was 22.7% (confidence interval: 19.4–26.4%). The prevalence of depressive symptoms among the older was a little higher in women (24.2%) than in men (19.4%), in rural (29.2%) than urban (20.5%) areas, and in western (30.5%) than eastern (19.5%) areas. In addition, the prevalence of depressive symptoms decreased with increasing levels of education. However, it did not increase gradually with age.ConclusionsThe prevalence of depressive symptoms among the older in China was a little high, and it was varied by gender, age, area, and education level. Copyright © 2012 John Wiley & Sons, Ltd.
ACR appropriateness criteria® ipsilateral radiation for squamous cell carcinoma of the tonsil
Authors: Yeung Anamaria Reyna , Garg Madhur Kumar , Lawson Joshua , McDonald Mark W. , Quon Harry , Ridge John A. , Saba Nabil , Salama Joseph K. , Smith Richard V. , Yom Sue S. , Beitler Jonathan J. ,   Expert Panel on Radiation Oncology—Head & Neck Cancer
Published: January 2012

AbstractBackgroundControversy exists as to the criteria for selecting patients with carcinoma of the tonsil for treatment with ipsilateral radiotherapy (RT).MethodsThe American College of Radiology (ACR) Appropriateness Criteria are evidence‐based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current literature from peer reviewed journals and the application of a well‐established consensus methodology (modified Delphi) to rate the appropriateness of treatment procedures by the panel. In those instances where evidence is not definitive, expert opinion may be used to recommend treatment.ResultsThe ACR Expert Panel on Radiation Oncology – Head and Neck Cancer developed consensus recommendations for selecting patients with tonsillar carcinoma for ipsilateral RT.ConclusionPatients that are appropriate for ipsilateral RT have less than 1 cm of tumor invasion into the soft palate or base of tongue, and nodal stage of N0 to 1. © 2012 American College of Radiology. Head Neck, 2012
Simple and Highly Efficient Catalytic Thiocyanation of Aromatic Compounds in Aqueous Media
Authors: Khazaei Ardeshir , Zolfigol Mohammad Ali , Mokhlesi Mohmmad , Panah Fateme Derakhshan , Sajjadifar Sami 
Published: January 2012

AbstractTwo simple, mild, and efficient procedures for the thiocyanation of N‐heterocycles, substituted anilines (electron‐rich and electron‐deficient), and N‐substituted aromatic amines at room temperature are reported (Table 3). The first uses H2O2 as pollution‐free oxidant and the second H5IO6; both with the reagent potassium thiocyanate in H2O as solvent. These procedures provided the target thiocyanates after a short reaction time in good to excellent yields and high regioselectivity.
A New Triterpene and Phenolic Compounds from the Roots of Pteroxygonum giraldii
Authors: Chai Xin , Su Yan‐Fang , Zhang Jun , Yan Shi‐Lun , Gao Yan‐Hong , Gao Xiu‐Mei 
Published: January 2012

AbstractA chemical investigation of the roots of Pteroxygonum giraldii led to the isolation of a new arborane‐type triterpene, pteroxygonumnol A (1), a new myricetin glycoside, myricetin 3‐O‐β‐D‐galactopyranoside 3′‐O‐β‐D‐xylopyranoside (2), and a group of phenolic lipids, 3–6, along with four known phenolic compounds, (−)‐epigallocatechin, (−)‐epigallocatechin gallate, gallic acid, and 2‐(4‐hydroxyphenyl)acetic acid. Their structures were elucidated on the basis of extensive spectroscopic analyses.