bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interpupillary and intercanthal distance values among females in AL-Qassim Region, KSA: A Cross-sectional study
Authors: Eltahir Manal Abdalla , Alnasser Imtinan , Aljaber Shatha 
Published: May 2024

Introduction:Managing posttraumatic cranial, orbitofacial, and maxillofacial deformities. Furthermore, these values facilitate the correction of telecanthus associated with trauma, moreover, it is useful in dentistry for selection of the artificial teeth in the construction of dentures.Aim:The aim of this study was to measure interpupillary as well as ICD among the female Saudi population aged between 19 and 25 years.Materials and Methods:This cross‐sectional study was conducted at Qassim University/Dental Clinic. Female dental students/Qassim University were the population, sample size was 56 subjects. The examination was done in the dental chair while the participant was in an upright position and looking straight. The ruler and Vernier caliper were used to measure the IPD and ICD in millimeters. The records for each subject were taken by two examiners.Results and Discussion:Age as independent variable and ICD and IPD measure as dependent (outcome variables). Statistical analysis was done using (SPSS) software, for Windows (version 21; IBM, Armonk, New York). D: The data were shown as frequency, percentages, mean, and standard deviation, and P value is considered significant if it is >0.05.Conclusion:IPD and CD are affected by age in females. The value of studied females’ subjects has been IPDs in the range of 52–64 mm and ICDs in the range of 24–37 mm. ICD is not half a distance of IPD in most of the studied subjects.
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
Authors: Yimthin Thatcha , Phunpang Rungnapa , Wright Shelton W. , Thiansukhon Ekkachai , Chaisuksant Seksan , Chetchotisakd Ploenchan , Tanwisaid Kittisak , Chuananont Somchai , Morakot Chumpol , Sangsa Narongchai , Silakun Wirayut , Chayangsu Sunee , Buasi Noppol , Lertmemongkolchai Ganjana , Chantratita Narisara , West T. Eoin 
Published: May 2024

ABSTRACT.
Melioidosis, infection caused by Burkholderia pseudomallei, is characterized by robust innate immune responses. We have previously reported associations of TLR1 single nucleotide missense variant rs76600635 with mortality and of TLR5 nonsense variant rs5744168 with both bacteremia and mortality in single-center studies of patients with melioidosis in northeastern Thailand. The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, there was no association of the rs76600635 variant with bacteremia (adjusted odds ratio [OR], 0.75; 95% CI, 0.54–1.04, P = 0.08) or 28-day mortality (adjusted OR, 0.96; 95% CI, 0.71–1.28, P = 0.77). There was no association of the rs5744168 variant with bacteremia (adjusted OR, 1.24; 95% CI, 0.76–2.03, P = 0.39) or 28-day mortality (adjusted OR, 1.22; 95% CI, 0.83–1.79, P = 0.21). There was also no association of either variant with 1-year mortality. We conclude that in a large multicenter cohort of patients hospitalized with melioidosis in northeastern Thailand, neither TLR1 missense variant rs76600635 nor TLR5 nonsense variant rs5744168 is associated with bacteremia or mortality.
Evaluation of antipsychotic side effects on schizophrenia patients at Dr Radjiman Wediodiningrat Hospital, Indonesia
Authors: Putri Divaz Hedya , Julaeha Julaeha , Sugianto Agus 
Published: May 2024

Background: Schizophrenia is the most common mental illness with a poor prognosis. Antipsychotics are the major treatment for Schizophrenia.
Objective: This study examines schizophrenia patients' side effects and antipsychotic medication.
Method: A retrospective study with cross-sectional observational analysis was conducted in June 2023, with only the data from schizophrenia patients in Dr. Radjiman Wediodiningrat Hospital, Indonesia. Data were collected from the prescription records of schizophrenia inpatients from January to June 2023. The Chi-square test was used to analyse and measure the relationship between the incidence of adverse events with antipsychotics in schizophrenia patients.
Result: Schizophrenia inpatients were majority male (74.7%) and the age 18-35 years was 41%. This study showed that the pattern of prescription of antipsychotics is atypical monotherapy (37.6%) and combinations (24.9%) were the most antipsychotics prescribed. Most of the schizophrenia outpatients have extrapyramidal syndrome side effects (31.9%), such as rigidity (12.2%), tremor (3.5%), dystonia (6.6%), and other side effects (11.8%).
Conclusion: This study highlighted that atypical antipsychotics were the most common choice for treatment in the inpatient setting. Atypical have a lower risk of extrapyramidal side effects than typical. The negative effects of atypical antipsychotics, including metabolic syndrome, have not been identified. Thus, more research is required.
Effect of montmorillonite K-10 catalyst on the synthesis of (E)-1-phenyl-3-(2-methoxyphenyl)-2-propen-1-one using the microwave irradiation method
Authors: Suzana  , Rohana Evieta , Budiati Tutuk 
Published: May 2024

Background: A research investigation was conducted to examine how the utilisation of the montmorillonite K-10 catalyst impacts the production of (E)-1-phenyl-3-(2-methoxyphenyl)-2-propen-1-one (PMPP) using the microwave irradiation method since the conventional method has not been successful.
Objective: The aim of this research was to investigate the impact of employing the montmorillonite K-10 catalyst in the synthesis of PMPP using the microwave irradiation method.
Method: The compound was created using the Claisen-Schmidt condensation technique through a nucleophilic addition reaction.
Results: The result of the synthesis was a yellowish powder. The percentage of synthesis of PMPP using the microwave irradiation method was 4.98%, with a melting point of 53-54oC. The synthesised compounds were identified by UV-Vis, Infrared and H-NMR spectroscopy.
Conclusion: Synthesis of PMPP with montmorillonite K-10 catalyst can be carried out using microwave irradiation. The synthesis using the montmorillonite K-10 catalyst gave a relatively small yield of (E)-1-phenyl-3-(2-methoxyphenyl)-2-propen-1-one compared to a strong base catalyst.
Penguatan Pemberantasan Kejahatan Jalanan dan Aksi Premanisme Tahun 2023
Authors: Saputra Azis 
Published: May 2024

Perkembangan masyarakat yang terus meningkat menimbulkan berbagai perubahan sosial yang dapat berupa perubahan norma, peraturan, dan kebiasaan. Salah satu dampak perubahan sosial adalah timbulnya kejahatan jalanan dan premanisme yang dapat menjadi ancaman potensial bagi kehidupan bermasyarakat dan bernegara. Aksi premanisme dapat dilakukan oleh kelompok kecil, maupun kelompok-kelompok besar seperti organisasi kemasyarakatan termasuk organisasi underbow dan lainnya. Pada Renstra 2015-2019, salah satu program Quick Wins Polri adalah pemberantasan preman dan aksi premanisme yang merupakan tindaklanjut dari Rencana Aksi Nasional. Oleh sebab itu, Puslitbang Polri perlu melakukan penelitian tentang “Penguatan Pemberantasan Kejahatan Jalanan dan Aksi Premanisme” dengan harapan dapat dijadikan dasar bagi pimpinan Polri dalam mengambil kebijakan. Penelitian ini menggunakan metode kualitatif dan kuantitatif. Responden terdiri dari masyarakat dan personel: Bagops, Satintelkam, Satbinmas; Satsamapta dan Satreskrim. Hasil penelitian menyebutkan: 1)Jenis kejahatan jalanan dan aksi premanisme yang paling banyak terjadi adalah Curanmor, Begal, Balapan Liar dan Penjambretan; 2)Rata-rata 2 dari 10 orang responden pernah menjadi korban kejahatan jalanan dan aksi premanisme; 3)Responden yang menjadi korban kejahatan jalanan dan aksi premanisme adalah mereka yang memiliki tingkat pendapatan rendah; 4)Mayoritas responden setuju partisipasi masyarakat sangat diperlukan untuk membantu dalam deteksi dan peringatan dini kejahatan jalanan dan premanisme; 5)Mayoritas responden setuju bahwa patroli Polisi memberikan dampak yang signifikan untuk menekan kejahatan jalanan dan premanisme; 6)Masyarakat mengharapkan polisi cepat datang ke tempat kejadian perkara dan menangkap serta memproses hukum pelaku tindak kejahatan jalanan dan premanisme; 7)Kemitraan Polri dan masyarakat memiliki peran penting dalam upaya deteksi dini dan peringatan dalam mewujudkan penguatan pemberantasan kejahatan jalanan dan aksi premanisme.
Insights into substance abuse knowledge and attitudes among high school students in Anbar Province, Iraq
Authors: Thamir Badea'a , Al-Rawi Ru’ya 
Published: May 2024

Background: The high prevalence of substance use among children and adolescents has become a major global public health concern. This study aims to explore adolescents' knowledge and attitudes toward substance abuse.
Methods: A cross-sectional study was conducted from January 2nd to February 15th, 2023 in Ramadi City, Anbar Province, Iraq. Students from eight high schools participated, selected through a multistage sampling approach. The bivariate analysis included independent sample t-tests and one-way ANOVA. Furthermore, a multivariable linear regression analysis was employed to predict factors influencing knowledge and attitudes. Statistical analyses were performed using SPSS version 16.
Results: The study included 415 students, with a mean age of 16.7 (±9.3) years, with a majority being male (52.8%). Accuracy rates for knowledge and attitude were 79.6% and 70.2%, respectively. About 79.3% of participants were familiar with terms related to drug abuse in Iraq. Regression analysis showed that higher knowledge scores were linked with male gender and a household income exceeding IQD 600,000 monthly (95% CI:1.311 to 2.923; P <0.001; and 95% CI:1.072 to 2.331; P =0.001), respectively. Attitudes toward drug abuse prevention were influenced by male participants and students with employed fathers (95% CI:1.245 to 4.302; P=0.025; and 95% CI: 2.073 to 6.737; P=0.032), respectively.
Conclusion: In conclusion, most of the students had sufficient knowledge and a constructive attitude toward drug use. Male gender, high income, and employed fathers were the main predictors.
REPRESENTASI SHAMANISME PADA MASYARAKAT KOREA MODERN DALAM FILM MAN ON THE EDGE (BAKSUGOENDAL)
Authors: N Suyanti 
Published: May 2024

ABSTRAKShamanisme Korea (muism) merupakan salah satu kepercayaan dengan sejarah panjang yang masih ada di tengah masyarakat Korea hingga saat ini. Di balik kemajuan teknologi, masyarakat Korea masih memercayai keberadaan shamanisme yang berakar kuat dan merupakan salah satu warisan budaya takbenda yang dilindungi oleh pemerintah Korea Selatan. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan studi kepustakaan untuk menjelaskan keberadaan shamanisme Korea dalam objek data, yaitu film bergenre komedi berjudul Man On The Edge (Baksugoendal). Teori yang digunakan adalah ‘Shamanisme Korea (muism)’ dari Kim Tae-kon dan teori ‘Representasi’ Stuart Hall. Hasil penelitian menunjukkan bahwa masyarakat Korea modern masih menjadikan nilai-nilai shamanisme sebagai alternatif pemecahan masalah serta budaya religi yang masih dipraktikan dalam kehidupan sehari-hari. Shamanisme Korea pada film juga direpresentasikan secara konstruksionis dalam bentuk adegan dan dialog yang menggambarkan tipe-tipe mudang (무당), prosesshinbyeong (신병), serta praktik ritual (굿) di tengah masyarakat Korea modern. Kata kunci: representasi, shamanisme Korea, mudang, shinbyeong, gut ABSTRACTKorean shamanism (muism) is a belief with a long history that still exists in Korean society today. Behind technological advances, Korean people still believe in the existence of shamanism which has deep roots and isone of the intangible cultural heritages protected by the South Korean government. This research uses a qualitative descriptive method with a literature study approach to explain the existence of Korean shamanism inthe data object, namely the comedy genre film entitled Man On The Edge (Baksugoendal). The theories used are Kim Tae-kon's 'Korean Shamanism (muism)' and Stuart Hall's 'Representation' theory. The research results show that modern Korean society still uses shamanistic values as an alternative solution to problems and religious culture is still practiced in everyday life. Korean shamanism in the film is also represented in a constructionist manner in the form of scenes and dialogue that describe the types of mudang (무당), the shinbyeong process (신병), and ritual practices (굿) in modern Korean society. Key words: representation, Korean shamanism, mudang, shinbyeong, gut
IDENTIFICATION OF MIKO IN JAPAN: RELIGIOUS AND CHANGING ROLES AS A PART-TIMER EMPLOYEE
Authors: Sari, Herlina Sunarti, Ni Luh Suparwati, M. Egi Wardana Rima Novita 
Published: May 2024

ABSTRACTMiko is a young woman thought to have power and function as an intermediary to connect with God. Folklorists for Japanese culture split this word into two groups: shrine-bound Miko or Kannagi Miko and shrine-not-bound Miko or Kuchiyose Miko. The shrine-bound Miko is responsible for performing kagura dance, which is the popular Shinto’s rite until now. This research will identify Miko in Japan and their responsibilities in religion. Religion that describes will follow Shomin Shinko or Shinto in particular. The study employed a qualitative approached with descriptive analysis. Based on the discourses, the shrine-bound and shrine-not-bound Miko are existed until now. However, there is some shifting in the roles. Once Miko plays significant parts as a mediator in some ceremonies, modern Miko may accept roles as part-timers in the shrine to clean and sell the shrine’s amulet. This research will provide the characteristics of Miko, including their duties and some history from the Nara period. The study can be used to understand the Miko roles in particular and Japanese culture. Keywords: Miko; Miko Roles; Japan Religion; Shomin Shinko ABSTRAKMiko adalah sebutan bagi perempuan muda yang dipercaya memiliki kekuatan dan bertugas sebagai mediasi untuk berinteraksi dengan Tuhan. Para ahli menyebutkan bahwa istilah ini dibagi menjadi dua grup, yaitu Miko terikat kuil atau disebut juga sebagai Kannagi Miko dan Miko tidak terikat kuil atau Kuchiyose Miko. Miko terikat kuil memiliki tugas untuk membawakan tarian kagura sebagai salah satu ritual terkenal di kuil Shinto hingga saat ini. Penelitian ini akan mengidentifikasikan Miko di Jepang dan tugas mereka terkait dengan kegiatan keagamaan. Keagamaan yang akan dijelaskan akan mengikuti Shomin Shinko atau khususnya adalah Shinto. Metode yang digunakan adalah pendekatan kualitatif dengan analisis deskriptif. Berdasarkan diskursus mengenai Miko, Miko terikat kuil dan Miko tidak terikat kuil masih ada di Jepang hingga saat ini. Namun demikian, terdapat pergeseran dari tugas-tugas mereka. Dahulu, Miko memainkan peran penting sebagai mediator di sebuah upacara keagaamaan, tetapi Miko saat ini (modern) memungkinkan bekerja sebagai pekerja paruh waktu di kuil untuk membersihkan kuil atau menjual jimat. Penelitian ini akan membawakan karakteristik Miko, termasuk tugas-tugas mereka dan beberapa sejarah yang ada sejak jaman Nara. Penelitian ini dapat memberikan pemahaman terhadap tugas-tugas Miko secara khusus di kebudayaan dan masyarakat Jepang. Kata kunci: Miko; Miko Roles; Japan Religion; Shomin Shinko
Comparison of the development of investigative skills between Project Based Learning and the Flipped Class
Authors: Junchaya Palomino Nelida Rosa , Diaz Espinoza Maribel , Garcia Atoche Gisella del Carmen , Armas Rebaza Laura Giovanna , Enrique Rivas Luis , Morocho Ricalde Carmen Julia 
Published: May 2024

This study compared the impact of Project Based Learning (PBL) with Flipped Classroom for developing scientific inquiry skills in 76 high school students. An Inquiry Skills Test was administered before and after the intervention to two study groups. Both groups experienced significant improvements ininquiry skills, with no statistically significant differences between them. A Pearson correlation analysis revealed a moderate correlation between PBL and the development of investigative skills. The results suggest that PBL and Reverse Classroom effectively improve these skills, with PBL showing a slightly stronger association.
Verantwoordingsonderzoek 2020
Authors: de Smit Ruud , Borg Robin 
Published: May 2024

Verantwoordingsonderzoek 2020
In de rubriek Beleidsonderzoek Benut besteden we dit keer aandacht aan het onderzoek naar de mate waarin fiscale regelingen voldoen aan het toetsingskader uit de Rijksbegrotingsvoorschriften.
Editor's Summaries of the Articles Published in This Issue of Precision Medicine Communications
Authors: Editorial Staff  
Published: May 2024

In this issue, Anum and colleagues have reported evidence-based prioritization and scoring of genomic loci interacting with pioglitazone therapeutic response in diabetic patients; Hasan and colleagues designed a study to determine the association of CP2C19*2 loss of function polymorphism with acute coronary syndrome patients receiving Clopidogrel, Zaheer, et al., reviewed escitalopram use in depression & the influence of genetic variations on its safety & efficacy, Ahmed and colleagues reviewed and discussed single nucleotide polymorphisms associated with the safety and efficacy of anti-gout medications, while Haroon et al., compiled, reviewed and discussed the studies showing the genetic influence on Losartan's antihypertensive and uricosuric actions.
Side Effects and Genetic Variation During Depression in Taiwanese Han Population
Authors: Staff Editorial 
Published: May 2024

Genetic variation can play a role in individual differences in the response to medications used for the treatment of depression, as well as in the occurrence of side effects. While there have been studies investigating genetic factors associated with antidepressant response and side effects, it is important to note that the field of pharmacogenetics is complex and influenced by multiple genetic and environmental factors. In the case of the Taiwanese Han population and depression, limited specific studies examining the relationship between genetic variation and antidepressant response or side effects have been conducted. Huang and colleagues analyzed the syndromal factor structures of the Hamilton Depression Rating Scale in 479 patients with MDD by using exploratory factor analysis. All patients were followed up biweekly for 8 weeks. In total, 33 independent SNPs for treatment responses were tested in a mixed model, 12 of which demonstrated a p value <0.05. The most significant SNP was rs2182717 in the ENSR00000803469 gene located on chromosome 6 for the core syndromal factor (β = -0.638, p = 1.8 × 10-4) in terms of symptom improvement over time. Patients with a GG or GA genotype with the rs2182717 SNP also exhibited a treatment response (β = 0.089, p = 2.0 × 10-6) at week 4. Moreover, rs1836075352 was associated with sexual side effects (p = 3.2 × 10-8). Pathway and network analyses using the identified SNPs revealed potential biological functions involved in treatment response, such as neurodevelopment-related functions and immune processes. In conclusion, they identified loci that may affect the clinical response to treatment with antidepressants in the context of empirically defined depressive syndromal factors and side effects among the Taiwanese Han population, thus providing novel biological targets for further investigation. Pharmacogenomics J. 2023 May;23(2-3):50-59. doi: 10.1038/s41397-023-00298-8.
Association of GABRG2 rs211037 Gene Polymorphism With Epilepsies and Pharmacoresistance to Anti-Epileptic Drugs; A Meta-Analysis
Authors: Ullah Shakir , Ali Saad , Ahmad Nisar , Zakria Muhammad , Nabi Muhammad , Ikram Muhammad 
Published: May 2024

GABRG2 protein which is a crucial part of GABA receptor encoded by the gamma-aminobutyric acid A receptor, gamma 2 (GABRG2) gene. The exonic GABRG2 rs211037 gene polymorphism has been commonly explore with respect to variable association to different types of epilepsies (all types, IGE and FS) and AEDs response. The current meta-analysis study was designed to explore whether the GABARG2 C588 T (rs211037) genetic variant predicts susceptibility to different types epilepsy and pharmacoresistance to AEDs. Twenty studies were included, contained 3351 epileptic patients and 3649 controls in meta-analysis, for the association GABRG2 rs211037 polymorphism with susceptibility to different types of epilepsy. Similarly, five studies comprised of 632 responder patients and 401 non-responder patients in meta-analysis, were selected for the evaluation of the GABRG2 rs211037 polymorphism to pharmacoresistance to AEDs. Meta-analysis was performed separately for FS and IGE in Asian and Caucasian population for association to epilepsies and pharmacoresistance to AEDs but pharmacoresistance to AEDs in FS and IGE was not performed in Asian and Caucasian due to limited number of studies. Meta-analysis showed a significant link between GABRG2 rs211037 polymorphism and susceptibility to all types of epilepsies in total Population in (CC vs CT, OR 1.03, 95% CI 0.0–1.2, p = 0.0006 and CC vs TT, OR 0.03, 95% CI 0.8–1.2, p = 0.01) genetic models. Similarly, a significant association of this polymorphisms with all types of epilepsy was found with Asian population in genetic models of CC vs CT( OR 0.86 (0.7-1.0,p=0.11), CC vs TT (OR 0.67 (0.5-0.9, p=0.000), but CC vs CT+TT genetic model shows the association of all types of epilepsies in Asian as well Caucasian population ( OR 0.6 (0.5-0.7), p=0.001 and OR 1.05 (0.9-1.2), p=0.000). Similarly, CC vs CT, CC vs TT and CC vs CT+TT genetic models were also associated with IGE and FS epilepsies in total population, Asian and Caucasian population. The alleles also showed a significant association with epilepsy. Genetic models of CC vs CT, CC vs TT and CC vs CT+TT were also associated with pharmacoresistance to AEDs (P<0.05) in total population, Asian and Caucasian population. The publication bias was not significant (P<0.05) but the heterogenicity (I2%) was mostly more than 50%. FS, caused by two studies with small sample sizes, however the possibility of false positive results because of significant studies for FS cannot be excluded. This study showed a significant association of GABRG2 rs211037 polymorphism with susceptibility to different types of epilepsies and pharmacoresistance to AEDs in all population. Future studies with larger sample sizes from different population are suggested to verify the results.