bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online Dialogue
Authors: Petković Tijana 
Published: May 2024

AbstractIn judging the relative merits of online, in‐person, and hybrid conferences and meetings, this article takes as a case study the Global Ecumenical Theological Institute (GETI), which took place as an in‐person phase held in conjunction with the 11th Assembly of the World Council of Churches in 2022, following an earlier online phase. The primary objective was to determine the level of satisfaction among participants with the online phase and whether they considered the online phase to have enhanced the productivity of the subsequent in‐person phase. The research found that the combination of online and in‐person phases was deemed an ideal approach for conferences and programmes such as GETI. While it would have been challenging for young researchers or students without previous assembly experience to keep up with the programme without a preparatory online phase, building friendships and connections solely through the online phase proved to be difficult. Accordingly, it is crucial to recognize the situations where in‐person meetings are necessary and effective versus those where online dialogue suffices.
Effectiveness of work‐based learning training in secondary family and consumer sciences
Authors: Miller Cynthia L. , Hough Twyla 
Published: May 2024

AbstractThis mixed methods study investigated the effectiveness of work‐based learning (WBL) experiences in secondary Family and Consumer Sciences (FCS) programs, focusing on bridging the gap between secondary education and workforce readiness. Participants included secondary FCS teachers from public middle and high schools in Texas. The findings highlight WBL integration challenges due to varying levels of awareness, training, and industry partnerships among FCS educators. Enhancements in teacher training and stronger industry–education partnerships are recommended to improve the quality and diversity of WBL, aiming to better prepare students for dynamic workforce demands.
Drought shortens subtropical understory growing season by advancing leaf senescence
Authors: Sun Huanfa , Yan Liming , Li Zhao , Cheng Wanying , Lu Ruiling , Xia Xingli , Ping Jiaye , Bian Chenyu , Wei Ning , You Cuihai , Tang Songbo , Du Ying , Wang Jing , Qiao Yang , Cui Erqian , Zhou Xuhui , Xia Jianyang 
Published: May 2024

AbstractSubtropical forests, recognized for their intricate vertical canopy stratification, exhibit high resistance to extreme drought. However, the response of leaf phenology to drought in the species‐rich understory remains poorly understood. In this study, we constructed a digital camera system, amassing over 360,000 images through a 70% throughfall exclusion experiment, to explore the drought response of understory leaf phenology. The results revealed a significant advancement in understory leaf senescence phenology under drought, with 11.75 and 15.76 days for the start and end of the leaf‐falling event, respectively. Pre‐season temperature primarily regulated leaf development phenology, whereas soil water dominated the variability in leaf senescence phenology. Under drought conditions, temperature sensitivities for the end of leaf emergence decreased from −13.72 to −11.06 days °C−1, with insignificance observed for the start of leaf emergence. Consequently, drought treatment shortened both the length of the growing season (15.69 days) and the peak growth season (9.80 days) for understory plants. Moreover, this study identified diverse responses among intraspecies and interspecies to drought, particularly during the leaf development phase. These findings underscore the pivotal role of water availability in shaping understory phenology patterns, especially in subtropical forests.
Acceptability of teledentistry use among residents and staff in aged residential care facilities in the Otago region of New Zealand
Authors: Ng Beatrice Ming Ming , Samaranayaka Ariyapala , Ting Graeme , Smith Moira 
Published: May 2024

ObjectivesTo assess ARC residents' and staff perceptions of the benefits of, and comfort with, teledentistry use in ARC facilities in the Otago region of NZ, and identify end‐user‐level factors associated with its use.BackgroundDifficulty in accessing oral healthcare services is a key barrier to aged residential care (ARC) residents' oral health and well‐being. Teledentistry offers a possible solution, yet studies on its acceptability in ARCs are sparse, especially in New Zealand (NZ). This study assessed ARC residents' and staff perceptions of the benefits of, and comfort with, teledentistry use in ARC facilities in the Otago region of NZ and identified end‐user‐level factors associated with its use.Materials and methodsRest home‐level residents and care staff in ARC facilities in the Otago region of NZ were surveyed to assess their awareness of teledentistry, perceptions of benefit and comfort using teledentistry, and end‐user‐level factors associated with the feasibility of using it in ARCs.ResultsOne hundred residents and 77 care staff from 14 facilities participated. Three‐quarters of resident participants thought that teledentistry was beneficial. Three in five resident participants were comfortable receiving remote dental consultations and care advice through teledentistry. Acceptability, as measured by perceived benefits and comfort, was lower among older participants. Staff participants were receptive to teledentistry use for residents and were comfortable facilitating remote dental consultations and care through teledentistry. No staff participants disagreed with the potential benefits of teledentistry for ARC residents.ConclusionTeledentistry would likely be acceptable to residents and staff in ARC facilities in NZ, contributing to residents' improved access to oral health care and improved oral health and well‐being.
‘High hopes for treatment’: Australian stakeholder perspectives of the clinical translation of advanced neurotherapeutics for rare neurological diseases
Authors: Nguyen Christina Q. , Kariyawasam Didu S. T. , Ngai Tsz Shun Jason , Nguyen James , Alba‐Concepcion Kristine , Grattan Sarah E. , Palmer Elizabeth E. , Hetherington Kate , Wakefield Claire E. , Dale Russell C. , Woolfenden Sue , Mohammad Shekeeb , Farrar Michelle A. 
Published: May 2024

AbstractIntroductionAdvanced therapies offer unprecedented opportunities for treating rare neurological disorders (RNDs) in children. However, health literacy, perceptions and understanding of novel therapies need elucidation across the RND community. This study explored healthcare professionals' and carers' perspectives of advanced therapies in childhood‐onset RNDs.MethodsIn this mixed‐methodology cross‐sectional study, 20 healthcare professionals (clinicians, genetic counsellors and scientists) and 20 carers completed qualitative semistructured interviews and custom‐designed surveys. Carers undertook validated psychosocial questionnaires. Thematic and quantitative data analysis followed.ResultsParticipants described high positive interest in advanced therapies, but low knowledge of, and access to, reliable information. The substantial ‘therapeutic gap’ and ‘therapeutic odyssey’ common to RNDs were recognised in five key themes: (i) unmet need and urgency for access; (ii) seeking information; (iii) access, equity and sustainability; (iv) a multidisciplinary and integrated approach to care and support and (v) difficult decision‐making. Participants were motivated to intensify RND clinical trial activity and access to advanced therapies; however, concerns around informed consent, first‐in‐human trials and clinical trial procedures were evident. There was high‐risk tolerance despite substantial uncertainties and knowledge gaps. RNDs with high mortality, increased functional burdens and no alternative therapies were consistently prioritised for the development of advanced therapies. However, little consensus existed on prioritisation to treatment access.ConclusionsThis study highlights the need to increase clinician and health system readiness for the clinical translation of advanced therapeutics for RNDs. Co‐development and use of educational and psychosocial resources to support clinical decision‐making, set therapeutic expectations and promotion of equitable, effective and safe delivery of advanced therapies are essential.Patient or Public ContributionParticipant insights into the psychosocial burden and information need to enhance the delivery of care in this formative study are informing ongoing partnerships with families, including co‐production and dissemination of psychoeducational resources featuring their voices hosted on the Sydney Children's Hospitals Network website SCHN Brain-Aid Resources.
Recruitment and retention of adolescents for an ecological momentary assessment measurement burst mental health study: The MHIM engagement strategy
Authors: Murray Aja L. , Xie Tong , Power Luke , Condon Lucy 
Published: May 2024

AbstractIntroductionRecruitment and long‐term retention of adolescent participants in longitudinal research are challenging and may be especially so in studies involving remote measurement and biosampling components. The ability to effectively recruit and retain participants can be supported by the use of specific evidence‐based engagement strategies that are built in from the earliest stages.MethodsInformed by a review of the evidence on effective engagement strategies and consultations with adolescents (via two Young Person Advisory Groups [YPAGs]; ages 11–13 and 14–17), the current protocol describes the planned participant engagement strategy for the Mental Health in the Moment Study: a multimodal measurement burst study of adolescent mental health across ages 11–19.ResultsThe protocol incorporates engagement strategies in four key domains: consultations/co‐design with the target population, incentives, relationship‐building and burden/barrier reduction. In addition to describing general engagement strategies in longitudinal studies, we also discuss specific concerns regarding engagement in data collection methods such as biosampling and ecological momentary assessment where a paucity of evidence exists.ConclusionEngagement strategies for adolescent mental health studies should be based on existing evidence and consultations with adolescents. We present our approach in developing the planned engagement strategies and also discuss limitations and future directions in engaging adolescents in longitudinal research.Patient or Public ContributionThe study design for this project places a strong emphasis on the active engagement of adolescents throughout its development. Specifically, the feedback and suggestions provided by the YPAGs have been instrumental in refining our strategies for maximising the recruitment and retention of participants.
Identification of the immune repertoire of γδ T‐cell receptors in psoriasis
Authors: Chen Yuting , Fu Quanze , Ma Yinjiang , Wang Nan , Yang Ji , Liang Qing , Wang Kejia , Gao Lujuan 
Published: May 2024

AbstractThe γδ T cells are a subpopulation of T cells that are abundantly found in the skin and mucous membranes. Their reactivity to self‐antigens and ability to secrete various cytokines make them a key component in psoriasis development. Although the correlation between the immune repertoire (IR) of γδ T‐cell receptors and the occurrence and severity of psoriasis remains incompletely explored, high‐throughput sequencing of γδ T cells has led to a deeper understanding of IR in psoriasis. This study investigated the differences between γδ T cells in patients with psoriasis and healthy controls. The γδ T cells were identified via immunofluorescence staining and a correlation analysis was performed according to the psoriasis area and severity index (PASI) scores. The IR sequencing method was used to detect IR in the γδ T‐cell receptors. The findings demonstrated more skin γδ T cells in patients with psoriasis, which were positively correlated with the PASI score. There were subtle differences in most variable (V), diversity (D) and joining (J) gene segments and VJ/VDJ combination segments between patients with psoriasis and healthy controls. However, a higher diversity of complementarity‐determining region 3 (CDR3) was observed in patients with psoriasis. In summary, the IR of skin γδ T cells was significantly altered in patients with psoriasis, and the diversity in the cell's CDR3 population is a promising biomarker for assessment of psoriasis severity.
Nurse educators' knowledge and opinions about the “One Health” approach
Authors: Ercan Şahin Nilay , Öner Mücahide 
Published: May 2024

AbstractAimThis study was conducted to reveal the knowledge and opinions of Turkish nurse educators about the One Health approach.BackgroundOne Health is a collaborative, multisectoral, and transdisciplinary approach working at local, regional, national, and global levels to achieve optimal health (and well‐being) outcomes recognizing the interconnections between people, animals, plants, and their shared environment. Despite nurses' unique position to address inequities in health care for all people around the world, the concept of One Health is a relatively new concept in nursing.MethodsThis is a cross‐sectional descriptive study involving a total of 272 nurse educators from various universities in Turkey. The email addresses of nurse educators were obtained from university websites, and the questionnaire form (created using the survey tool Google Forms) was then sent to them. Open‐ended questions underwent content analysis, while multiple‐choice questions were analyzed in terms of numbers and percentages.ResultsEighty‐two percent of nurse educators had never heard of or encountered the One Health approach before. Ninety‐six percent of nurse educators think that the One Health approach should be included in nursing education. Nurse educators asserted that nursing should be included as a discipline in the One Health approach due to its relationship with the environment, health prevention and promotion, and its close contact with society.ConclusionThe results of this study underscore the necessity of enhancing One Health knowledge among nursing educators. It is particularly significant that the majority of nurse educators had not previously encountered or been aware of the One Health approach, highlighting an important gap in awareness and understanding.Implications for nursing and nursing policyNursing, silent in the realm of One Health, should integrate this approach, which encompasses human, animal, and environmental health, into nursing education, research, and practice. It is time for action to incorporate One Health into both undergraduate and graduate nursing education programs, conducting research in this area, and fostering collaborations.
Regulatory emotional self‐efficacy and self‐compassion mediate anxiety, depression, body image distress and subjective well‐being in women with polycystic ovary syndrome: A cross‐sectional study
Authors: Wang Guangpeng , Liu Xueyan , Zhu Shujuan , Lei Jun 
Published: May 2024

AbstractAimsThis study aims to investigate the mediating role of regulatory emotional self‐efficacy and self‐compassion in the relationship among anxiety, depression, body image distress and subjective well‐being among women with polycystic ovary syndrome.DesignA cross‐sectional study.MethodsThe study recruited 510 women with polycystic ovary syndrome from a tertiary hospital affiliated with a university in Hunan Province, China. The study employed several tools to collect data, including the Generalized Anxiety Scale, the Patient Health Questionnaire‐9, the Body Image States Scale, the Self‐Compassion Scale, the Regulatory Emotional Self‐Efficacy Scale and the Index of Well‐being questionnaire. Data analysis was carried out using descriptive analysis, spearman correlation analysis, ordinary least squares regression and bootstrapping.ResultsThe study's findings indicate that regulatory emotional self‐efficacy and self‐compassion both act as mediators in the connection between anxiety, depression, body image distress and subjective well‐being among women with polycystic ovary syndrome.ConclusionThe study emphasizes the significance of regulatory emotional self‐efficacy and self‐compassion in promoting well‐being among women with polycystic ovary syndrome. It also implies that interventions targeted at enhancing these factors could potentially enhance the subjective well‐being of women affected by PCOS.ImpactOur study's primary contribution is to underscore the crucial mediating roles of regulatory emotional self‐efficacy and self‐compassion in the relationship among anxiety, depression, body image distress and subjective well‐being. Our study indicates that clinical practitioners should prioritize improving the regulatory emotional self‐efficacy and self‐compassion of women with polycystic ovary syndrome, reducing their anxiety, depression and body image distress and improving their subjective well‐being.Reporting MethodThis study was reported according to the Standards for Reporting Qualitative Research (SRQR).Patient or Public ContributionNo patient or public contribution outside of participation in the actual study for purposes of data collection.
Physiological thermal niches, elevational ranges and thermal stress in dendrobatid frogs: An integrated approach
Authors: Pintanel Pol , Tejedo Miguel , Camacho Agustín , Enriquez‐Urzelai Urtzi , Llorente Gustavo A. , Merino‐Viteri Andrés 
Published: May 2024

AbstractAimWe investigated the relationship between thermal physiology, elevational distribution and thermal stress among nine closely related dendrobatid frogs during their aquatic stage by employing an integrated approach, combining thermal physiology, environmental temperature modelling and predictive assessments of current and future exposure to thermal variation.LocationEcuador.TaxonAmphibians; Anura, Dendrobatidae, Epipedobates, Hyloxalus.MethodsWe determined the thermal performance curves (TPCs) of larval growth for each species and modelled the thermal variation in contrasting aquatic larval environments for both present and future times. This allowed us to estimate the expected elevational distributions and forecast periods of exposure to stressful temperatures that inhibit larval growth due to elevation and global warming.ResultsWe found significant correlations between optimum temperature (Topt), 50% maximum performance temperature (maxB50), 50% minimum performance temperature (minB50) and cold resistance (survival at 9°C) with the current elevational distributions. However, thermal physiology predicted lower than observed distributions for high‐elevation dendrobatids and higher than observed maximum elevations for lowland species. Nonetheless, our models predicted that low thermal variability habitats (i.e. streams and deep permanent ponds) can buffer the future temperature increase for all taxa, even when considering the most extreme scenario. In contrast, all species within high thermal variation habitats (open forest temporary ponds) are expected to experience stressful temperatures under present conditions.Main ConclusionsThe findings indicate that thermal physiology may not be a limiting factor for dendrobatid frog species' ranges in this equatorial mountain gradient. Highland species may need to adapt to suboptimal performance, while some lowland species could occupy higher elevations. This study emphasizes the importance of habitat buffering to mitigate thermal stress in the face of climate change for amphibians in tropical mountains.
Recent advances in CAR‐T cell therapy for acute myeloid leukaemia
Authors: Gao Chi , Li Xin , Xu Yao , Zhang Tongcun , Zhu Haichuan , Yao Di 
Published: May 2024

AbstractAcute myeloid leukaemia (AML) is a fatal and refractory haematologic cancer that primarily affects adults. It interferes with bone marrow cell proliferation. Patients have a 5 years survival rate of less than 30% despite the availability of several treatments, including chemotherapy, allogeneic haematopoietic stem cell transplantation (Allo‐HSCT), and receptor antagonist drugs. Allo‐HSCT is the mainstay of acute myeloid leukaemia treatment. Although it does work, there are severe side effects, such as graft‐versus‐host disease (GVHD). In recent years, chimeric antigen receptor (CAR)‐T cell therapies have made significant progress in the treatment of cancer. These engineered T cells can locate and recognize tumour cells in vivo and release a large number of effectors through immune action to effectively kill tumour cells. CAR‐T cells are among the most effective cancer treatments because of this property. CAR‐T cells have demonstrated positive therapeutic results in the treatment of acute myeloid leukaemia, according to numerous clinical investigations. This review highlights recent progress in new targets for AML immunotherapy, and the limitations, and difficulties of CAR‐T therapy for AML.
Internet of things‐based approach for glycemic control in people with type 2 diabetes: A randomized controlled trial
Authors: Bouchi Ryotaro , Izumi Kazuo , Ishizuka Naoki , Uemura Yukari , Ohtsu Hiroshi , Miyo Kengo , Tanaka Shigeho , Satoh‐Asahara Noriko , Hara Kazuo , Odawara Masato , Kusunoki Yoshiki , Koyama Hidenori , Onoue Takeshi , Arima Hiroshi , Tsushita Kazuyo , Watada Hirotaka , Kadowaki Takashi , Ueki Kohjiro 
Published: May 2024

ABSTRACTAimsThe utilization of long‐term effect of internet of things (IoT) on glycemic control is controversial. This trial aimed to examine the effect of an IoT‐based approach for type 2 diabetes.Materials and MethodsThis randomized controlled trial enrolled 1,159 adults aged 20–74 years with type 2 diabetes with a HbA1c of 6.0–8.9% (42–74 mmol/mol), who were using a smartphone on a daily basis were randomly assigned to either the IoT‐based approach group (ITG) or the control group (CTG). The ITG were supervised to utilize an IoT automated system that demonstrates a summary of lifelogging data (weight, blood pressure, and physical activities) and provides feedback messages that promote behavioral changes in both diet and exercise. The primary end point was a HbA1c change over 52 weeks.ResultsAmong the patients, 581 were assigned to the ITG and 578 were in the CTG. The changes in HbA1c from baseline to the final measurement at 52 weeks [mean (standard deviation)] were −0.000 (0.6225)% in ITG and − 0.006 (0.6449)% in CTG, respectively (P = 0.8766). In the per protocol set, including ITG using the IoT system almost daily and CTG, excluding those using the application almost daily, the difference in HbA1c from baseline to 52 weeks were −0.098 (0.579)% and 0.027 (0.571)%, respectively (P = 0.0201). We observed no significant difference in the adverse event profile between the groups.ConclusionsThe IoT‐based approach did not reduce HbA1c in patients with type 2 diabetes. IoT‐based intervention using data on the daily glycemic control and HbA1c level may be required to improve glycemic control.