bluuebunny/crossref_metadata_2025_split huggingface dataset:
AJCC 7th edition of TNM staging accurately discriminates outcomes of patients with resectable intrahepatic cholangiocarcinoma
Authors: Farges Olivier , Fuks David , Le Treut Yves‐Patrice , Azoulay Daniel , Laurent Alexis , Bachellier Philippe , Nuzzo Gennaro , Belghiti Jacques , Pruvot François René , Regimbeau Jean Marc 
Published: November 2010

AbstractBACKGROUND:This year, the 7th edition of the AJCC staging manual has for the first time attributed a unique pTNM staging to intrahepatic cholangiocarcinoma (IHCC) that is intended to replace the 2 Western and ideally also the 2 Eastern systems currently in use. This proposal, which has not yet been validated, was tested in the current study.METHODS:Among 522 patients operated on with curative intent for an IHCC between 1994 and 2008 in tertiary hepatobiliary centers, those with mass‐forming‐type IHCCs, an R0 resection, and accurate pathological node staging were retained for evaluation. The distribution of these patients and their actuarial survival in the new TNM stages (as well as in the 4 previous ones) were compared.RESULTS:Only 163 patients fulfilled the inclusion criteria, mainly because of the lack of routine lymphadenectomy, but patients and tumors characteristics of this population were representative. These patients were evenly distributed between AJCC 7th edition stages (stage I, 28%; stage II, 32%; stage III, 35%), which was not the case for the other systems. With an average follow‐up of 34 months in survivors, the AJCC 7th edition was more discriminating than the others in predicting survival (median for stage I not reached; for stage II, 53 months, P = .01; for stage III, 16 months, P < .0001). Survival of these patients according to the 2 Japanese classifications was identical to that anticipated.CONCLUSIONS:The 7th edition is clinically relevant and may be applicable worldwide, provided routine lymphadenectomy at the time of surgery for IHCC becomes the standard of care. Cancer 2011. © 2010 American Cancer Society.
A randomized phase 2 study of docetaxel and S‐1 versus docetaxel and cisplatin in advanced gastric cancer with an evaluation of SPARC expression for personalized therapy
Authors: Jeung Hei‐Cheul , Rha Sun Young , Im Chong Kun , Shin Sang Joon , Ahn Joong Bae , Yang Woo Ick , Roh Jae Kyung , Noh Sung Hoon , Chung Hyun Cheol 
Published: November 2010

AbstractBACKGROUND:The purpose of this study was to compare 2 weekly docetaxel‐based regimens as first‐line treatments for advanced gastric cancer and to investigate the expression of secreted protein acidic and rich in cysteine (SPARC) and its abilities to predict treatment‐related clinical outcomes.METHODS:Patients were randomly selected to receive 3 weekly cycles of docetaxel (35 mg/m2 on days 1 and 8) plus S‐1 (35 mg/m2 each twice daily on days 1‐14) (DS), or docetaxel plus cisplatin (35 mg/m2 each on days 1 and 8) (DC). Endpoints included overall response rate (primary), survival, toxicity, and quality of life (secondary). SPARC expression in prechemotherapy specimens of primary gastric tumors was evaluated via immunohistochemical analysis.RESULTS:Eighty patients were enrolled in the study. Confirmed overall response rates were 46% (95% confidence interval, 30%‐62%) for DS and 24% (95% confidence interval, 11%‐38%) for DC via intent‐to‐treat analysis. Median progression‐free survival was 7.3 and 4.9 months and overall survival was 16.0 and 8.3 months for DS and DC, respectively. The most common grade ≥3 toxicity was neutropenia. Grade ≥3 mucositis (18%) and hand‐foot syndrome (8%) were the toxicities most associated with DS, whereas anorexia (20%) and lethargy (20%) were more common with DC. High SPARC expression was related to early progression (hazard ratio, 3.67; P = .042) and poor overall survival (hazard ratio, 2.01; P = .010) in docetaxel chemotherapy on multivariate analysis.CONCLUSIONS:The outcomes in this study favored DS over DC for further phase 3 study. The findings suggest that split‐dose weekly docetaxel alleviates hematological toxicity without compromising efficacy, and that SPARC expression may help individualize therapy in advanced gastric cancer. Cancer 2011. © 2010 American Cancer Society.
B‐cell receptor epitope recognition correlates with the clinical course of chronic lymphocytic leukemia
Authors: Binder Mascha , Müller Fabian , Jackst Antje , Léchenne Barbara , Pantic Milena , Bacher Ulrike , zu Eulenburg Christine , Veelken Hendrik , Mertelsmann Roland , Pasqualini Renata , Arap Wadih , Trepel Martin 
Published: November 2010

AbstractBACKGROUND:B‐cell receptors (BCRs) and their recognition of specific epitopes may play a pivotal role in the development and progression of chronic lymphocytic leukemia (CLL). In this study, the authors set up a model system to explore epitope reactivity and its clinical relevance in CLL.METHODS:Epitope‐mimicking peptides were selected from phage display libraries on 6 CLL BCRs from randomly chosen patients. The binding of the 6 index epitope mimics was evaluated in a set of 100 unrelated CLL samples. Epitope recognition patterns were correlated with the clinical course of the disease.RESULTS:Surprisingly, all CLL samples recognized 1 or several index epitopes, and some revealed marked polyreactivity. Patients with CLL who expressed BCRs that reacted with ≥5 epitope mimics had a significantly worse clinical course than less polyreactive patients (median time to first treatment, 24 months vs 102 months). This effect was independent of otherwise known prognostic markers.CONCLUSIONS:The authors introduced a system with which to model epitope reactivity of CLL BCRs without previous knowledge of potential antigens. The findings indicated that a polyreactive epitope recognition pattern may be a determinant of an aggressive clinical course in this disease. This further emphasizes the functional and prognostic relevance of BCR epitope recognition in CLL. Cancer 2011. © 2010 American Cancer Society.
Patterns and outcome of relapse after autologous stem cell transplantation for mantle cell lymphoma
Authors: Dietrich Sascha , Tielesch Blanca , Rieger Michael , Nickelsen Maike , Pott Christiane , Witzens‐Harig Mathias , Kneba Michael , Schmitz Norbert , Ho Antony D. , Dreger Peter 
Published: November 2010

AbstractBACKGROUND:Autologous stem cell transplantation (autoSCT) has improved the outcome of patients with mantle cell lymphoma (MCL) considerably. However, little is known about the patterns and outcome of MCL recurrence after autoSCT.METHODS:The authors conducted a retrospective study of 118 patients with MCL who underwent autoSCT from August 1992 to August 2008 at 3 different referral centers in Germany.RESULTS:Fifty‐two relapses occurred for a cumulative incidence of 46% after 5 years. Only 3 patients relapsed after 5 years (at 90 months, 91 months, and 171 months) after undergoing autoSCT. A Cox regression analysis of the incidence of relapse identified not receiving rituximab before autoSCT and undergoing salvage autoSCT as predictive factors for relapse, whereas cytosine arabinoside intensification; a total body irradiation‐based, high‐dose regimen; patient age; and year of transplantation had no influence. The median overall survival (OS) after relapse was 23 months. Twenty patients (39%) underwent allogeneic stem cell transplantation (alloSCT) for relapse, and 11 of those patients remained in ongoing complete remission at the time of the current report. It is noteworthy that there were 4 long‐term survivors who lived for >5 years after relapse even without undergoing alloSCT. A Cox regression analysis of OS after relapse revealed that the response duration after autoSCT was an adverse predictor of OS, whereas alloSCT was associated with a significantly longer OS after relapse.CONCLUSIONS:The current results indicated that autoSCT was capable of inducing long‐term remission up to 16 years after treatment, but the outcome of patients with MCL who relapsed after autoSCT was poor, especially if their response duration after autoSCT was short. However, for a subset of patients with relapsed MCL, alloSCT may offer the possibility of durable survival, and individual patients can enjoy long‐term survival after relapse even without undergoing alloSCT. Cancer 2011. © 2010 American Cancer Society.
Oxidative stability of oils containing olive leaf extracts obtained by pressure, supercritical and solvent‐extraction
Authors: Jimenez Paula , Masson Lilia , Barriga Andrés , Chávez Jorge , Robert Paz 
Published: November 2010

AbstractThe effect of the addition of olive leaf (Olea europaea, cv. Arbequina) extracts, i.e. hydroalcoholic (ethanol–water 1:1; OHE), juice (OJ) and supercritical fluid‐CO2 (OSFE) on the oxidative stability of vegetable oils with different unsaturation, such as soybean oil (SBO), canola oil (CO) and high oleic sunflower oil (HOSO), were studied at two concentrations (250 and 630 mg/kg oil, expressed as caffeic acid equivalent (CAE)). The extracts were characterized by the total phenolic content (Folin–Ciocalteau method), phenol chromatographic profiles (LC‐MS) and antioxidant activity (DPPH). OHE showed the highest phenol content (7.7 mg CAE/mL) while OJ and OSFE showed values of 5.4 and 2.2 mg CAE/mL, respectively. Oleuropein and its derivatives were the major phenolic compounds identified in OHE. The addition of 630 mg CAE/kg oil of OHE and OSFE to HOSO, SBO and CO showed an antioxidant effect, increasing significantly the induction time (IT) (p<0.05). That effect was highest when the system was more monounsaturated. In contrast, OJ showed a pro‐oxidant effect for all oils systems for both concentration studied. This behaviour could be attributed to the diphenol oxidase (PPO) activity.
Evaluation of well‐differentiated/de‐differentiated liposarcomas by high‐resolution oligonucleotide array‐based comparative genomic hybridization
Authors: Tap William D. , Eilber Fritz C. , Ginther Charles , Dry Sarah M. , Reese Nicholas , Barzan‐Smith Kate , Chen Hsiao‐Wang , Wu Hong , Eilber Frederick R. , Slamon Dennis J. , Anderson Lee 
Published: November 2010

AbstractWell‐differentiated/de‐differentiated liposarcomas (WDLS/DDLS) encompass an intriguing disease model in which a temporal intersection occurs between the malignant transformation of mesenchymal cells and the process of adipogenesis. Deciphering the molecular events that trigger and are characteristic of the intersection of these oncogenic and normal processes is critical to affect the often morbid and lethal consequences of malignant tumors of fat. High‐resolution genome‐wide oligonucleotide array‐based comparative genomic hybridization (aCGH) with matched gene expression analyses was performed on seven lipomas, one hibernoma, and 38 WD and DDLS to define and compare the genomic events associated with these tumors. WD and DDLS had complex karyotypes. On average, WDLS had 11.1 and DDLS had 22.7 chromosomal copy number aberrations. All of the liposarcomas had 12q13‐q15 amplifications with varying peaks at CDK4 (12q14.1), HMGA2 (12q14.3), and MDM2 (12q15); 24% of the DDLS and no WDLS had 1p32.2 (JUN) amplifications; 33% WDLS and 35% DDLS had 1q24.3 amplifications involving DNM3 and miR‐214/miR‐199a2; 24% of the liposarcomas had 6q23‐q24 amplifications (including MAP3K5). Amplifications in GLI1 (12q13.3), JUN, and MAP3K5 (6q23.3) were mutually exclusive and occurred predominately in the DDLS. 6q amplifications occurred primarily in retroperitoneal tumors and females represented the majority of those patients who developed fatty tumors prior to the age of 50 years old. This detailed genetic mapping provides insight into the heterogeneity of WD and DDLS and the chromosomal and genetic abnormalities that are present in and distinguish these mesenchymal malignancies. © 2010 Wiley‐Liss,Inc.
Application of radially varying magnetic field on a peristaltic flow of non‐Newtonian fluid in the presence of heat and mass transfer
Authors: Nadeem S. , Akbar Noreen Sher 
Published: November 2010

AbstractThis article deals with the variable MHD effects on the peristaltic flow of a non‐Newtonian fluid in the presence of heat and mass transfer. The walls of annulus are maintained at different temperatures. Continuity, momentum concentration, and energy equations are utilized in the mathematical analysis. Two types of solutions, namely, the exact and numerical, are derived. These solutions are compared and discussed. © 2010 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/htj.20314
Biamphiphilic triblock copolymer micelles as a multifunctional platform for anticancer drug delivery
Authors: Zhu Wen , Li YanLi , Liu LiXin , Zhang WenLong , Chen YongMing , Xi Fu 
Published: November 2010

AbstractNovel micelles from biamphiphilic triblock copolymer poly(ethylene glycol)‐b‐poly(ε‐caprolactone)‐b‐poly(acrylic acid) (PEG‐b‐PCL‐b‐PAA) as new multifunctional nanocarriers to delivery anticancer drugs were evaluated. The well‐defined triblock copolymers prepared by controlled polymerizations self‐assembled into micelles in aqueous solution with a hydrodynamic radius of 13 nm as obtained by dynamic light scattering (DLS) and a low critical micellization concentration of 2.9 × 10−4 g/L. The hydrophobic PCL cores of micelles were applied to load hydrophobic drug doxorubicin and the functional PAA subcoronas clung to the micellar core were used to carry cisplatin through covalent interaction. The results indicated that two anticancer drugs had been loaded by different mechanism either separately or simultaneously. Drug loading content and efficiency as well as release profiles were evaluated. Furthermore, internalization and cytotoxicity of the anticancer nanoparticles against human bladder carcinoma EJ cells were studied. The biamphiphilic triblock copolymer micelles provided not only biocompatibility and biodegradability, but also abilities for loading single and dual anticancer drugs, indicating that this was a useful multifunctional platform for anticancer drug delivery. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Feasibility of using a liver infected with Clonorchis sinensis for liver transplantation: Fourteen cases
Authors: Zhu Zhi-Jun , Shen Zhong-Yang , Gao Wei , Zheng Hong , Deng Yong-Lin , Pan Cheng , Sun Li-Ying , Zeng Zhi-Gui , Sun Ji-San 
Published: November 2010

Abstract
Use of livers infected with Clonorchis sinensis as donor organs for transplantation is controversial because of the potential associated risks. The low availability of donor livers at Tianjin First Center Hospital since 2003 prompted us to undertake cadaveric liver transplantation in 14 patients using donor livers infected with C. sinensis. None of the donors had been diagnosed with liver fluke infection before organ procurement, and in none of them was there laboratory evidence of abnormal liver function. After livers had been harvested and preserved, dead liver flukes were found in the bile of each donor; subsequent pathological examination of the flukes confirmed the diagnosis of clonorchiasis. Conventional orthotopic liver transplantation, with insertion of a T- tube, was undertaken in all 14 patients. Praziquantel, 25 mg/kg three times daily for two days, was administrated to the recipients starting on postoperative day 2. Results of tests of liver function improved rapidly after the operation in all of the patients. The median duration of follow-up was 31 months. The 1- and 3-year survival rates of the grafts were 85.7% and 78.6%, respectively. Postoperative biliary complications occurred in 2 patients (14.3%). No ova were detected in the bile or feces of any of the patients postoperatively. These findings suggest that livers infested with C. sinensis can be used as donor organs for liver transplantation. Further studies are required to establish definitive criteria for determining whether such donor organs may be used in a liver transplantation program. Liver Transpl 16:1440–1442, 2010. © 2010 AASLD.
Studies on the Cure Reaction and Relationship between Network Structure/Thermal Properties of Styrene Copolymers Based on Adypic/Sebacic Acid Modified Unsaturated (Epoxy) Polyesters
Authors: Worzakowska Marta 
Published: November 2010

AbstractThe studies on the relationship between network structure/thermal properties of styrene copolymers based on adypic/sebacic acid modified unsaturated (epoxy) polyesters cured using different hardeners as well as the course of the cure reaction of polyesters with styrene have been presented. The adypic/sebacic acid modified unsaturated polyesters (UP) prepared from 4‐cyclohexene‐1,2‐dicarboxylic anhydride (THPA), maleic anhydride (MA), adypic acid (AA) or sebacic acid (SA) and ethylene glycol (EG) and their epoxy derivatives: adypic/sebacic acid modified unsaturated epoxy polyesters (UEP) were subjected to the cure process with styrene using diacyl peroxide: benzoyl peroxide (BPO) or the mixture of BPO/suitable acid anhydride: 4‐cyclohexene‐1,2‐dicarboxylic anhydride (THPA) or glutaric anhydride (GA). Thermal properties were evaluated by means of DSC, TG and DMA analyses. It was proved that studied properties were significantly depended on polyester's structure and the type of applied curing system. Generally, higher values of E'20°C, tgδmax,E”, νe, IDT, Tkfor styrene copolymers based on UEP were obtained. It was connected with more cross‐linked polymer network structure due to the possible copolymerization reaction of carbon‐carbon double bonds of polyester with styrene and additional polyaddition of epoxy to anhydride groups or thermal curing of epoxy groups. The additional connections between polyester's chains led to obtain more stiff and thermal stable polymeric materials. Moreover, the increase of saturated aliphatic acid's chain length in polyester backbone caused the decrease of E'20°C, tgδmax,E”, νe, IDT, Tkvalues of styrene copolymers. It suggested that copolymers based on polyesters prepared from acid containing more methylene groups in their structure were characterized by more flexible polymer network due to the “laxity” effect of aliphatic chains.
Poly(3,4‐ethylenedioxythiophen)/Poly(4‐styrenesul‐fonate): Thin Films and Microfibers
Authors: Yan Hu , Okuzaki Hidenori 
Published: November 2010

AbstractThis Feature Article describes our recent researches on processing poly(3,4‐ethylenedioxythiophene /poly(4‐styrenesulfonate) (PEDOT/PSS) colloidal dispersion into thin films which exhibit high conductivity and high transparency, and into microfibers which exhibit high conductivity and high mechanical strength. The state‐of‐the‐art thin films and microfibers are expected to utilize to sophisticated touch screens and wearable electronic devices as organic transparent electrodes and woven electric circuits, respectively.
Extrusion cooking properties of white and coloured rice varieties with different amylose content
Authors: Sompong Rutrada , Siebenhandl‐Ehn Susanne , Berghofer Emmerich , Schoenlechner Regine 
Published: November 2010

AbstractFive white and coloured rice varieties with different AM contents (long grain rice: 34%, Thai Jasmine rice: 15%, glutinous rice: 7%, red rice: 18% and black rice: 5%) were pregelatinised using a twin‐screw extruder at a barrel temperature of 150°C and two levels of feed moisture (12 and 16%). The correlation of AM content to water absorption index (WAI), water solubility index (WSI), starting viscosity, hot viscosity and final viscosity of the five rice extrudates were determined. Total anthocyanin content (TAC), total phenolic content (TPC) and antioxidant activity of extrudates were analysed by spectrophotometric methods. AM content was positively correlated to WAI and final viscosity. High AM content of the rice varieties resulted in high WAI and high final viscosity of extrudates. In addition, higher feed moisture content (16%) increased WAI and pasting properties of rice extrudates, but decreased WSI. Extrusion cooking reduced TAC, TPC and antioxidant properties, but the remaining values were high enough to suggest a further use for (functional) food production.
Statistical analysis on the effect of capacitance mismatch in a high‐resolution successive‐approximation ADC
Authors: Wakimoto Tsutomu , Li Hongxing , Murase Keita 
Published: November 2010

AbstractThis paper describes the statistical analysis of the effect of capacitance mismatch on the accuracy of a high‐resolution successive‐approximation analog‐to‐digital converter (ADC), which employs a split capacitor array to achieve high resolution. An analysis has been made for the following two types of capacitor digital‐to‐analog converters (DACs). One is the capacitor DAC with binary‐weighted capacitor array. The other is that which uses the segmented capacitor array for the upper bits to relax the matching requirement. The analysis was verified using the Monte‐Carlo simulation with capacitance mismatch. This analysis clarifies the required capacitance matching for a given ADC resolution and provides with a guideline for the optimum design. © 2010 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Application of Kelvin technique in a gas‐sensor read‐out circuit
Authors: Choji Hiroaki , Matsuoka Toshimasa , Im Jongpil , Wang Jun , Taniguchi Kenji 
Published: November 2010

AbstractThis letter proposes the design of a read‐out circuit for a carbon nanotube gas‐sensor array. The designed circuit relaxes the on‐resistance restrictions of the sensor selection switches with the Kelvin technique. Experimental results reveal the effectiveness of the Kelvin technique in the fabricated read‐out circuit. © 2010 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Captured by the camera's eye: Guantánamo and the shifting frame of the Global War on Terror
Authors: VEEREN ELSPETH VAN 
Published: November 2010

AbstractIn January 2002, images of the detention of prisoners held at US Naval Station Guantanamo Bay as part of the Global War on Terrorism were released by the US Department of Defense, a public relations move that Secretary of Defense Donald Rumsfeld later referred to as ‘probably unfortunate’. These images, widely reproduced in the media, quickly came to symbolise the facility and the practices at work there. Nine years on, the images of orange-clad ‘detainees’ – the ‘orange series’ – remain a powerful symbol of US military practices and play a significant role in the resistance to the site. However, as the site has evolved, so too has its visual representation. Official images of these new facilities not only document this evolution but work to constitute, through a careful (re)framing (literal and figurative), a new (re)presentation of the site, and therefore the identities of those involved. The new series of images not only (re)inscribes the identities of detainees as dangerous but, more importantly, work to constitute the US State as humane and modern. These images are part of a broader effort by the US administration to resituate its image, and remind us, as IR scholars, to look at the diverse set of practices (beyond simply spoken language) to understand the complexity of international politics.