bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipitension and cardiometabolic risk factors in young people
Authors: Sineglazova A. V. , Fakhrutdinova A. Sh. , Kim T. Yu. , Parve S. D. 
Published: May 2024

Aim. To study the relationship of lipitension and cardiometabolic risk (CMR) factors in young people.Material and methods. The case-control study on general obesity (GO) (overweight — 33,3%, GO — 33,3%) included 191 patients (Me=35,0 [30,0-39,0] years; F/M=97(50,8%)/94(49,2%)) without cardiometabolic diseases, comparable by sex and age. The prevalence and characteristics of lipitension were studied, taking into account the features of dyslipidemia and increased blood pressure (BP). Depending on the presence of lipitension, 2 groups were identified in which the CMR factors were studied: GO and abdominal obesity (AO), visceral fat, prediabetes, insulin resistance, increased C-reactive protein (CRP), hyperuricemia, glomerular filtration rate changes. Data were processed using SPSS Statistics 26.Results. Overall, the incidence of increased BP was 36,1%, hypertension (HTN) — 16,2%, and dyslipidemia — 73,3%. Lipitension was diagnosed in 25,1% of patients. At the same time, increased BP and HTN without combination with dyslipidemia were detected less frequently (13,1% and 5,2%, respectively). Dyslipidemia without increased BP and HTN, on the contrary, is more common (48,2%). Lipitension is more often diagnosed in men than in women — 32 (66,7%) and 16 (33,3%), p=0,005; [odds ratio=2,6; 95% confidence interval: 1,32-5,18]. In patients with lipitension, 43,8% were diagnosed with HTN, while the remaining 56,2% had BP ≥130/85 mm Hg. In the structure of dyslipidemia in lipitension, 79,2% had abnormalities in ≥2 lipid parameters, of which increased levels of low-density lipoprotein cholesterol (LDL-C) and hypercholesterolemia (78,3%) were most often detected. Persons with lipitension more often had AO (31,2%), increased glycated hemoglobin (HbA1c) >6% (39%) and insulin resistance (36,2%) than those without lipitension (p=0,026, p=0,018, p=0,044, respectively). With lipitension, a higher level of visceral fat (Me=8 [6-9] units) and HbA1c (Me=5,6 [5,1-6,0]%) was established than without it (Me=6 [4-9]U and Me=5,4 [5,1-5,9]%, respectively p=0,000 and p=0,018).Conclusion. Increased BP and HTN are more often found in combination with dyslipidemia than as an independent risk factor. In lipitension, the largest number of patients had ≥2 lipid metabolism disorders, most often represented by increased LDL-C and hypercholesterolemia. The presence of lipitension was associated with AO, increased HbA1c, and insulin resistance.
Confluências entre artes, saúdes, ambiente, escutas e comunicações: a vivência do Projeto Ilha dos Abraços no território quilombola da Ilha de Maré em Salvador, Bahia, Brasil
Authors: Floss Mayara , Lopes Maristela Menezes , Carvalho Lorena Bomfim de , Santos Iris Bomfim dos , Barbosa Marly Antonia Nascimento , Zardo Isadora Zanella , Milonopoulos Alexis , Saldiva Paulo Hilário Nascimento , Vianna Nelzair Araujo 
Published: May 2024

Este artigo se propôs a construir coletivamente com a comunidade da Ilha de Maré, localizada em Salvador, Bahia, Brasil; um texto-território-denúncia sobre a necropolítica ambiental e a resistência da comunidade. O projeto Ilha dos Abraços, parte do projeto guarda-chuva Planet&Ar, se propôs trabalhar vigilância popular através de uma residência artística com um grupo transdisciplinar de artistas, profissionais da saúde e urbanistas para realizar um mapa de memórias com as histórias da comunidade e painéis de grafite que se comunicassem em um “livro navegável”. A residência artística aconteceu entre 11-20/11/2022 com a realização de oficinas de quadrinhos, grafite, saúde planetária, sete painéis de grafite e entrevistas para a composição do mapa de memórias. Há a necessidade de saber pisar no território para adentrar uma comunidade quilombola e a percepção não apenas da tradição oral da Ilha de Maré, mas também a da escuta, e se propõe o termo “escutação”. Reflete-se também sobre a invisibilização da ilha frente à poluição e aos poderes públicos, de forma que a arte transgride este silenciamento. Assim, saúde planetária pode ser uma aliada para a luta da comunidade, porém questiona-se o conceito universalizante, propondo-se a ideia de saúde(s) planetária(s).
Research on University Laboratory Resource Sharing and Cooperative Management
Authors: Jundan Wang  
Published: May 2024

As the core place for technological innovation, the management level of university laboratories is directly related to the improvement of scientific research efficiency and innovation ability. This study deeply explores the current situation, problems, influencing factors, and management models of resource sharing and cooperative management in university laboratories. In terms of resource sharing, it is necessary to establish a sound resource sharing platform and mechanism; In terms of cooperation management, cooperation mechanisms and communication coordination should be strengthened; In terms of collaborative innovation, promoting innovation through interdisciplinary cooperation; In terms of knowledge management, promote knowledge acquisition, storage, and sharing. In the future, the development of digitization and intelligence will provide more opportunities for resource sharing and collaborative management. Universities should grasp the development trend, strengthen technology research and application promotion, in order to better serve technological innovation and social development.
Psychosocial elements as correlates of academic disposition of adolescents living with grandparents
Authors: Okorite Kienka Rita , Yetunde Fashina Abiola 
Published: May 2024

Academic excellence from students is desirable to parents, but recently the passion to strive for such success seems to be dwindling among female adolescent secondary school students hence the need for this study which examined psychosocial elements as correlates of the academic disposition of adolescents living with grandparents. A correlational research method was applied. Three research questions were raised and three hypotheses were formulated. The population comprised 253 female students randomly selected from nine senior secondary schools from four Local Government Areas of Education District III. Instruments used for data collection were the Rosenberg self-esteem scale and a self-developed questionnaire by the researcher tagged Academic Disposition and Sexual Proneness Questionnaire (ADSPQ). Data obtained were analyzed using descriptive statistics, Pearson Product Moment Correlation Coefficient, and Multiple Regression. Findings revealed that adolescent students living with grandparents in Education District III do not necessarily get involved in sexual activities because of their living conditions. One recommendation made was grandparents should be encouraged to engage in sexuality and sex-related conversations with their children as early as possible.
Keywords: academic excellence; Adolescents; female students; grandparents; sexual-proneness
Notes on Indian Cyperaceae
Authors: Korlahalli B. C. 
Published: May 2024

In this paper, a new subspecies of CyperusÂ sanguinolentus Vahl is described. Changes in the nomenclature of five species of Cyperus are gien. One new plant record for India, five or eastern India and two for W. Bengal are presented. Critical notes on Cyperus alopecuroides Rottb. and on C. corymbosus Rottb. complex are also included.
Propolis as an Adjuvant for Colon Cancer Chemotherapy: Exploring its Potential on Apoptosis, Cell Cycle, and PI3K Expression
Authors: Eka Mustika Suryani , Lelo Aznan , Pahlevi Nasution Iqbal , Anjelisa Hasibuan Poppy , Chairani Eyanoer Putri , Ichwan Muhammad , Effendi Rustam , Mustofa  
Published: May 2024

يُعتقد أن البروبوليس كعلاج كيميائي مشترك يقلل من شدة الآثار الضارة للعلاج الكيميائي. من المتوقع أن يؤدي الجمع بين البروبوليس والعلاج الكيميائي إلى تحفيز موت الخلايا المبرمج، وإيقاف دورة الخلية، وتقليل تنظيم التعبير عن )-3 PI3K ) وبالتالي تقليل تكاثر خلايا سرطان القولون WiDr . تم الحصول على خلايا WiDr من مختبر الطفيليات بكلية الطب بجامعة غادجاه مادا في يوجياكارتا بإندونيسيا. يتم جمع ا البروبوليس من قبل النحالين في كابانجاهي، شمال سومطرة. تم اختبار السمية الخلوية لخط خلايا WiDr باستخدام مقايسة تقنية Microculture Tetrazolium (MTT).
تم تقسيم مجموعة العلاج إلى سبع مجموعات فرعية. تضمنت التجربة معالجة خلايا WiDr بمواد مختلفة: K للمجموعة الضابطة، F لـ 20 ميكروغرام/مل 5-FU، O لـ 5 ميكروغرام/مل أوكساليبلاتين، P لـ 7.5 ميكروغرام/مل بروبوليس ، PF لمزيج من 7.5 ميكروغرام / مل بروبوليس و 20 ميكروغرام / مل 5-FU، PO لمزيج من 7.5 ميكروغرام / مل بروبوليس و 5 ميكروغرام / مل أوكساليبلاتين، و FO لمزيج من 5 ميكروغرام / مل أوكساليبلاتين و 20 ميكروغرام / مل 5-FO. تم استخدام قياس التدفق الخلوي للتحقيق في موت الخلايا المبرمج، ودورة الخلية، وملامح PI3K. أدى الجمع بين البروبوليس مع 5-FU أو أوكساليبلاتين إلى تعزيز موت الخلايا المبرمج المبكر والمتأخر. بالإضافة إلى ذلك، لوحظ تثبيط دورة الخلية في المرحلتين G0-G1 وS عندما تم دمج البروبوليس مع 5-FU أو أوكساليبلاتين. تم تثبيط تعبير PI3K بواسطة البروبوليس بالاشتراك مع 5-FU أو أوكساليبلاتين. أظهر البروبوليس، المستخدم كعلاج كيميائي مشترك، فعالية مضادة للسرطان من خلال تحفيز موت الخلايا المبرمج، وتعزيز دورة الخلية، وقمع تعبير PI3K.
Spectrophotometric determination of 4-ethylphenol using cloud point extraction in different water samples
Authors: Mousa Imran Alaa , Ahmed Dhahir Saadiyah , Jassim muklive Ahmed 
Published: May 2024

تصف هذه الدراسة تطوير تقنية سهلة ورخيصة ودقيقة وسريعة لقياس 4-اثيل فينول وتنطوي الطريقة الأولية على تحويل -3 نيترو انيلين إلى ملح ديازونيوم ثم التفاعل مع 4 - إثيل فينول في وسط قلوي.المعقد المتكون هو أصفر اللون وله امتصاص عند اعلى طول موجي عند 426 nm. ويتبع قانون بير في مدى خطي قدره 5-12 μg mL-1 مع معامل ارتباط قدره 0.994 وامتصاص مولاري 6.0024x10^3 L.mol-1.cm-1 وتم استُخدِام تقنية نقطة السحابة لقياس كميات قليلة جدا من الفينول باستخدام TritonX-114 كمفاعلات خافضة للتوتر السطحي، ومن ثم تم القياس باستخدام مقياس طيفي للأشعة فوق البنفسجية. وكانت قيمة معامل الارتباط 0.998، وكان الاامتصاص المولاري هو 1.0476 × 104 L.mol-1.cm-1، وكان المدى الخطي 2-11 μg mL-1 . وحُددت حدود الكشف والتحديد الكمي بأنها 0.42103 و0.140345 μg mL-1، على التوالي. وقد استخدمت الطريقة المقترحة بنجاح لتحديد الفينول في العينات البيئية المختلفة.
WITHDRAWN: Pneumonia in children with complex chronic conditions with tracheostomy: An emerging challenge
Authors: García-Boyano Miguel , Alcalá Francisco José Climent , Alonso Aroa Rodríguez , de Villalta Marta García Fernández , Alonso Ohiane Zubiaur , Retolaza Ignacio Rabanal , Melero Inmaculada Quiles , Calvo Cristina , García Luis Escosa 
Published: May 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Enhanced postoperative mobilization and biotracking after colorectal oncological resection (INTENSE) – study protocol for a randomized controlled trial
Authors: Willner Antonie , Kirkgöz Kürsat , Bessick Bernadette E , Klotz Susanne G R , Zapf Antonia , Vojinovic Marina , Auinger Julia , Brodersen Freya , Schneider Tobias , Stremme Jana , Melling Nathaniel , Hackert Thilo , Welsch Thilo 
Published: May 2024

Abstract

Background: Enhanced recovery after surgery (ERAS) is a multimodal perioperative care pathway originally designed to minimize perioperative stress and accelerate postoperative recovery in patients undergoing colorectal surgery. Early mobilization is one central element in the postoperative ERAS setting; however, evidence regarding effective training goals and specific early mobilization protocols is lacking. Therefore, the purpose of this randomized trial is to evaluate an enhanced postoperative mobilization (EPM) programaccompanied by activity and biotrackingafter minimally invasive colorectal surgery for colorectal carcinoma (CRC).
Methods/Design: Patients undergoing minimally invasive resection for CRC will be included in this randomized controlled single-centre trial. Further inclusion criteria areage ³18 years, physical mobility, andsigned informed consent. Patients will be randomized 1:1 for participation in an EPM program within an established ERAS setting during the first five postoperative days (PODs). The patients have two health care staff-assisted physiotherapy sessions a day and wear activity tracker devices to meet daily target step count goals. The control group follows a standard ERAS recommendation. The hierarchical primary endpoints are (i) the time to achieve five predefined discharge criteria (DC) and (ii) the number of steps during PODs 1-5. The sample size (n=50 patients in each group) was calculated based on these DCin a recent test cohort. We hypothesize that more patients would achieve DC by POD 6 after the intervention and would ambulate more. The secondary endpoints includethe GI-2 criterion, activity time, vital signs recorded by activity tracking, mobility level, length of hospital stay, quality of life, 30-day morbidity, and mortality.
Discussion: Individualized EPM programs have rarely been studied in homogeneous minimally invasive colorectal surgery cohorts within a controlled ERAS setting. Today, current available evidence does not support specific EPM protocols to further reduce hospital stays. Biotracking may be an additional motivational factor for enhanced mobilization. This study will provide evidence on the feasibility and effectiveness of a clearly defined EPM beginning on the day of surgery and on patient-reported outcomes.
Trial registration: German Clinical Trials Register. DRKS00033443. Registered on 25 January 2024.
miRNAs in umbilical cord tissue in neonates with different birth weights: a pilot study
Authors: García-Muro Cristina , Toledo-Gotor Cristina , Pasamón-García Sara , Heras María de Pablo-de las , Esteban-Zubero Eduardo , Prado María Yolanda Ruiz del , Domínguez-Garrido Elena 
Published: May 2024

Abstract

Background: Birth weight has been defined as an indicator of perinatal health. miRNAs are small non-coding RNA molecules between 18 and 25 nucleotides that regulate gene expression. Specific miRNAs have been implicated in metabolic pathways that influence fetal growth, so their dysregulation may contribute to birth weight alterations. Our objective was to recover amplifiable miRNAs from umbilical cord tissue and to compare their expression among three groups of patients.
Methods: The study was conducted in a sample 23 patients: 8 small for gestational age (SGA), 10 large for gestational age (LGA) and 5 appropriate for gestational age (AGA) subjects. Umbilical cord tissue samples were obtained immediately after childbirth, stored and then processed. miRNAs expression profile was analyzed in these samples through high-throughput sequencing. The results were assessed through bioinformatic analysis.
Results: We identified significant differences in levels of 6 miRNAs. Compared with AGA and LGA, miR-324-3p was downregulated in SGA, miR-337-3p was upregulated in LGA in comparison to both SGA and AGA, miR-760 was downregulated in LGA compared to SGA and AGA, and miR-4707-3p, miR-548a-3p and miR-6733-5p were upregulated in both SGA and LGA in comparison to AGA. Most of these molecules could be associated with the transforming growth factor-beta signaling pathway.
Conclusions: This exploratory study suggests that the expression of miRNAs in umbilical cord tissue is associated with birth weight. Our findings highlight the downregulation of miRNA-324-3p in SGA newborns, leading us to conclude that its decrease could serve as a marker for low birth weight.
Does a theory-based intervention to improve accountability reduce low-value preoperative tests for patients undergoing low-risk surgery? A pragmatic cluster randomized controlled trial protocol.
Authors: Kirkham Kyle , Patey Andrea M , Mortazhejri Sameh , Ortiz Alfonso , Taljaard Monica , Thavorn Kednapa , Presseau Justin , Bryson Gregory L , Levinson Wendy , Sklar Barbara , Linklater Stefanie , Bhatia Sacha , Grimshaw Jeremy M 
Published: May 2024

Abstract

Background: Low value preoperative tests ordered for patients without any clinical indication undergoing low-risk surgery can lead to further unnecessary investigations or treatments of false-positives. Identified drivers of ordering such low value preoperative tests include uncertainty about who should be responsible for test ordering, perceived inability to cancel tests ordered by fellow physicians and tests being completed before anesthesiologists assess patients. These findings informed a theory-based intervention increasing accountability in the hospital for preoperative test ordering. The objective of the proposed randomised trial is to evaluate whether this intervention reduces unnecessary preoperative tests (ECGs and Chest X-Rays) in patients undergoing low-risk surgery.
Methods: A cluster randomized trial in 22 Ontario hospitals is planned. Eligible hospitals, those falling between the 26th-100th centile for their rate of routine low value preoperative test ordering, will be randomly allocated into the intervention arm (a multicomponent intervention including changing hospital policy, identification of a local champion, delivering an education workshop, and restructuring patient flow and responsibility) or control arm (usual care). A process evaluation will determine whether the intervention is delivered as designed and local champions’ experiences of the delivering the intervention (fidelity). An economic evaluation will determine if the intervention offers good value for money from the perspective of Canada’s health care system. The primary outcome, defined at the level of the hospital, is the proportion of patients receiving one or more low-value preoperative tests within 60 days before surgery. Secondary outcomes are proportions of patients with overnight admission, re-operation in 24 hours, and 30-day all-cause mortality from the date of surgery, in addition to the proportion of patients receiving each of the above preoperative tests individually.
Discussion: Designing interventions to target the de-implementation of low-value care, is critical to improving healthcare for Canadians. Systematically addressing the barriers in a theory-informed manner, and by identifying the most appropriate intervention components for those barriers, increases the likelihood that the intervention will reduce unnecessary care delivered to patients.
Trial registration: ClinicalTrials.gov Identifier: NCT05526495; Registered September 2, 2022
Comparison of two ultrasound-guided brachial plexus block techniques for upper limb orthopaedic procedures in adults
Authors: Yang Xiongtiao , Zeng Jian , Peng Xiaomin , Lei Hongyi , Liu Xianbao , Lu Xiaoqin , Zhong Xiao , Cai Yuna , Chen Hailin 
Published: May 2024

Abstract

This prospective randomized trial was conducted to compare the quality and outcome of perioperative anesthesia between axillary brachial plexus block combined with axillary nerve block (axillary approach group,AX) and supraclavicular brachial plexus block( supraclavicular block group, SU). The primary outcome measure was to compare anesthesia quality evaluation including sensory function, motor function, and subjective feeling scores during skin incision, 30 minutes after skin incision, and at the end of surgery, and postoperative analgesia maintenance time score. Secondary outcomes included the number of patients in whom sufentanil was used, dexmedetomidine (Dex) dose, duration of sensory and motor blocks, number of patients who required remedial analgesia, and procedural complications.The proportion of patients in whom good-to-excellent anesthesia quality was achieved in AX group and SU group were 80% and 76.7%, respectively; anesthesia failure did not occur in both groups. Both procedures met the needs of surgical anesthesia and analgesia. Anesthesia quality and incidence of sufentanil use did not significantly differ between the groups. The incidence of phrenic nerve palsy was significantly higher in the supraclavicular block group (30% vs. zero; P = 0.002).Ultrasound-guided axillary brachial plexus block combined with axillary nerve block can achieve similar anesthesia quality and outcome as supraclavicular brachial plexus block,and found to have similar success rates. Trial registratio: http://www.chictr.org.cn with the registration number of ChiCTR2200057906. Date of first trial of 21/03/2022.
Wetter East Asia and Western United States with projected delayed Southern Ocean warming
Authors: Kim Hanjun , Kang Sarah , Pendergrass Angeline , Lehner Flavio , Shin Yechul , Ceppi Paulo , Yeh Sang-Wook , Song Se-Yong 
Published: May 2024

Abstract

Under global warming, precipitation over East Asia and the Western United States is projected to increase, though associated uncertainties are large. We argue that these precipitation enhancements are partly due to teleconnection from the Southern Ocean, which absorbs anthropogenic heat and gradually releases it with a delay. Based on climate model experiments, we show that the delayed Southern Ocean warming contributes to the tropical Pacific warming, enhancing precipitation during summer in East Asia and winter in the Western United States. An El Niño-like atmospheric teleconnection links the Southern Ocean warming to the Northern Hemisphere regional precipitation increases. Southern Hemisphere low clouds are a key regulator of this teleconnection, partly explaining the projected uncertainty of the regional precipitation. The documented teleconnection has practical implications: even if climate mitigation reduces carbon dioxide levels, the delayed Southern Ocean warming will sustain a wetter East Asia and the Western United States for decades to centuries.
Deep Learning Model Based on CT Images to Predict Ki-67 Expression in Renal Carcinoma
Authors: Shen Dan , Shi Bingye , Ma Tao , Zhou Bin , Gao Chao , Liu Yibo , Cui Zhenyu 
Published: May 2024

Abstract

Objective To establish a preoperative prediction model of Ki-67 expression in renal carcinoma by combining CT images of renal carcinoma with deep learning technology, and to evaluate its effect in clinical application.Methods A retrospective analysis was performed on the CT images and pathological data of 137 patients with renal carcinoma who underwent renal CT plain scan plus enhancement scans and who were diagnosed pathologically from January 2019 to November 2023 at the Affiliated Hospital of Hebei University. All recruited patients were divided into 35 cases with Ki-67 ≥ 10% and 102 cases with Ki-67 < 10% based on Ki-67 expression. Of these, 110 patients were divided into the training group and the test group in a 4:1 ratio, and the remaining 27 cases were used as clinical validation group. Based on the Mobilenetv3-large model, prediction models incorporating plain scan, arterial, venous and excretion phases were constructed using the training set data. The predictive performance of the models, including accuracy, accuracy, sensitivity, specificity, F1 score, and AUC values, were assessed by inputting CT images of the test group. The best-performing model was applied to the clinical validation group to compare the predicted results with the actual results of pathology; the accuracy, sensitivity, specificity and Kappa coefficient of the model were calculated to assess its clinical efficacy.Results The Mobilenetv3-large model in the venous phase showed the best performance in terms of accuracy, sensitivity and F1 score, as well as relatively high precision and AUC value, indicating good robustness. In the clinical validation group, the model predicted Ki-67 expression with an accuracy of 0.814, sensitivity and specificity of 0.889 and 0.667 at low and high levels, respectively, and a Kappa coefficient of 0.57.Conclusion The Mobilenetv3-large model based on venous-phase CT images is potentially clinically valuable as it can effectively predict Ki-67 expression and provide accurate, efficient, and noninvasive support for the development of personalized treatment plans.