bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neutralizing antibody responses against contemporary and future influenza A(H3N2) viruses in paradoxical clades elicited by repeated and single vaccinations
Authors: Zhang Ting , Han Yang , Huang Weijuan , Wei Hejiang , Zhao Yingze , Shu Liumei , Guo Yaxin , Ye Beiwei , Zhou Jianfang , Liu Jun 
Published: June 2024

AbstractAs one of the most effective measures to prevent seasonal influenza viruses, annual influenza vaccination is globally recommended. Nevertheless, evidence regarding the impact of repeated vaccination to contemporary and future influenza has been inconclusive. A total of 100 subjects singly or repeatedly immunized with influenza vaccines including 3C.2a1 or 3C.3a1 A(H3N2) during 2018–2019 and 2019–2020 influenza season were recruited. We investigated neutralization antibody by microneutralization assay using four antigenically distinct A(H3N2) viruses circulating from 2018 to 2023, and tracked the dynamics of B cell receptor (BCR) repertoire for consecutive vaccinations. We found that vaccination elicited cross‐reactive antibody responses against future emerging strains. Broader neutralizing antibodies to A(H3N2) viruses and more diverse BCR repertoires were observed in the repeated vaccination. Meanwhile, a higher frequency of BCR sequences shared among the repeated‐vaccinated individuals with consistently boosting antibody response was found than those with a reduced antibody response. Our findings suggest that repeated seasonal vaccination could broaden the breadth of antibody responses, which may improve vaccine protection against future emerging viruses.
Evaluation of circulating IgG antibodies against Porphyromonas gingivalis or its gingipains as serological markers of periodontitis and carriage of the bacterium
Authors: Massarenti Laura , Nielsen Claus Henrik , Danielsen Anne Katrine , Jensen Peter Østrup , Enevold Christian , Damgaard Christian 
Published: June 2024

AbstractBackgroundIncreasing evidence indicates that periodontitis contributes to systemic low‐grade inflammation. Porphyromonas gingivalis is strongly associated with periodontitis, and antibodies against the bacterium may be used as a serological proxy to account for periodontal status, when studying diseases associated with periodontitis. The aim of the present study is to identify an easily accessible and reliable serological biomarker for determination of periodontal status and oral carriage of the bacterium.MethodsSaliva and serum samples were collected from periodontally healthy controls (n = 27), and patients with periodontitis stage II (n = 12) or stages III or IV (n = 44). Serum levels of immunoglobulin G (IgG) antibodies against intact and fragmented P. gingivalis, recombinant gingipains (RgpA and RgpB), and the bacteria Escherichia coli and Capnocytophaga ochracea as controls were quantified with a multiplex bead‐based assay. P. gingivalis was identified in saliva using quantitative polymerase chain reaction (qPCR).ResultsSerum IgG antibodies against P. gingivalis whole bacteria were good indicators of periodontitis (area under the curve [AUC]: 0.75, 95% confidence interval [CI]: 0.64–0.85). The same was observed for levels of antibodies against P. gingivalis fragments (AUC: 0.78, 95% CI: 0.68–0.88). Likewise, levels of antibodies against P. gingivalis whole bacteria or P. gingivalis fragments were good indicators of oral carriage of P. gingivalis (AUC: 0.92, 95% CI: 0.86–0.98 and AUC: 0.96, 95% CI: 0.92–1, respectively). Conversely, antibodies against recombinant RgpA and RgpB were not good indicators of periodontitis or oral carriage of the bacterium. None of the antibody levels differed significantly between stage II and stage III or IV periodontitis.ConclusionSerum IgG antibody levels against heat‐inactivated whole P. gingivalis proved to be the preferable biomarker for periodontitis and oral carriage of the bacterium.
Microflexiblity and local integrability of horizontal curves
Authors: Pino Álvaro del , Shin Tobias 
Published: June 2024

AbstractLet be an analytic bracket‐generating distribution. We show that the subspace of germs that are singular (in the sense of control theory) has infinite codimension within the space of germs of smooth curves tangent to . We formalize this as an asymptotic statement about finite jets of tangent curves. This solves, in the analytic setting, a conjecture of Eliashberg and Mishachev regarding an earlier claim by Gromov about the microflexibility of the tangency condition.From these statements it follows, by an argument due to Gromov, that the ‐principle holds for maps and immersions transverse to .
Weakly compact sets in Orlicz–Bochner sequence spaces
Authors: Gong Wanzhong , Shi Siyu , Shi Zhongrui 
Published: June 2024

AbstractIn this work, we give three kinds of criteria for weak sets in Orlicz–Bochner sequence spaces without constraints, conditions posited in each criterion are necessary and sufficient. As an application, we give criteria for weak sets in Orlicz sequence spaces. Well‐known conclusions are exhibited once more, such as Schur's theorem, Banach–Alaoglu's theorem, and the boundedly compact principle of finite dimension space. The results obtained show that the weak compactness may not be extrapolated straightforwardly from to , for example, .
Step‐Growth Polymerized Systems of type “A3 + A1”: A Method to Calculate the Bivariate (Molecular size) × (Square Radius of Gyration) Number Distribution
Authors: Hillegers L.Tom , Slot Johan J. M. 
Published: June 2024

AbstractStep‐growth polymerized systems of type “A3 + A1” are considered. The monomers bear, respectively, 3 or 1 reactive A group. During the reaction, an A group on one monomeric unit might react with an A group on another such unit, thus chemically coupling the two units involved. Complexly structured polymeric molecules are formed. The A3's act as branching points; the A1's as end cappers. At the end of the reaction, the population of molecules present in the reactor vessel varies in size and branching structure. A method is presented to calculate the bivariate (molecular size) × (square radius of gyration) number distribution. It is shown that within the class of molecules of the same size, their square radius of gyration follows a shifted gamma distribution. Two new molecular parameters are introduced: the D index and the G index. The method uses bivariate generating functions.
Evaluation of cell‐laden three‐dimensional bioprinted polymer composite scaffolds based on synthesized photocrosslinkable poly(ethylene glycol) dimethacrylate with different molecular weights
Authors: Unagolla Janitha M. , Tillekeratne Liyanaaratchige V. , Jayasuriya Ambalangodage C. 
Published: June 2024

AbstractThis manuscript aims to three‐dimensional bioprint and evaluate new polymer composite scaffolds based on synthesized poly(ethylene glycol) dimethacrylate (PEGDMA) as well as methyl cellulose and gelatin. The PEGDMA was synthesized by a simple microwave‐assisted method using three distinct molecular weights (MWs) of poly(ethylene glycol) (PEG), 3, 6, and 12 kDa, and methacrylic anhydride. The percent functionalization of the PEGDMA was analyzed using the nuclear magnetic resonance spectrum, and the theoretical calculations indicated that over 50% of methacrylation was achieved in all samples, with the PEGDMA synthesized from 6 kDa PEG surpassing 66% methacrylation. These three PEGDMA‐based bioinks were investigated for their suitability for bioprinting scaffolds. It was observed that lower MW PEGDMA resulted in a higher degree of crosslinking, leading to more stable composite scaffolds. However, higher crosslinking degree did not support long‐term cell viability when encapsulated with cells. Higher MW PEGDMA showed higher cell viability over time though overall stability was lower. Synthesized PEGDMA with 6 kDa PEG showed both stability and long‐term cell viability after postprinting. Over 80% of cell viability was maintained for a 7‐day study period, showing potential use in tissue engineering applications as a cell delivery vehicle.
Will the substitution policy resolve the shortage of personal protection equipment?
Authors: Chen Jiguang , Chen Lu , Chen Ying‐Ju 
Published: June 2024

AbstractPersonal protective equipment (PPE) like face mask is important in managing pandemic. Typically, there exist different standards for face masks such as N95 and KN95. In response to the supply shortages of N95 mask in 2020, KN95 mask was allowed to be sold in U.S. to substitute the standard product N95. This paper considers when suppliers make products to supply both domestic and overseas markets with different product standards (i.e., the standard product for domestic/overseas market is the ordinary/high‐type product), and explore the impact of the substitution policy of allowing the ordinary product as a substitutable product in the overseas market. Analytically we prove that this substitution policy is win‐win by increasing the sales in both markets when ordinary and high‐type products are close substitutes in the presence of strong diseconomies of scale in material supply, or the high‐type product has a dominant competitive advantage in the presence of strong economies of scale in material supply. By contrast, the substitution policy is lose‐lose by decreasing the sales in both markets when the competitive advantage of the high‐type product is small in the presence of strong economies of scale in material supply. Moreover, numerical studies with the real data show the robustness of our analytical findings, and unfold the backfire of imposing export restriction on the standard product for domestic market.
Improving 3D printability and interlayer adhesion in ABS/PP immiscible polymer blends
Authors: Yesu Aleti , T. Ranjana , Goyal Sourabh , Banerjee Shib Shankar 
Published: June 2024

AbstractPrintability and interlayer adhesion are the most critical issues in 3D printing of immiscible polymer blends. It can affect structural integrity and mechanical performance of the printed parts. In this work, an effective strategy to improve the printability and interlayer adhesion of immiscible acrylonitrile‐butadiene‐styrene/polypropylene (ABS/PP) blends was implemented by introducing styrene–ethylene/butylene–styrene copolymer grafted with maleic anhydride (SEBS‐g‐MA) as a compatibilizer. The printability of the developed blends was investigated using rheological properties such as absolute value of complex viscosity, loss tangent and die‐swell ratio. Interestingly, it was found that the additive manufactured blends with 20 wt% SEBS‐g‐MA loading showed improved interlaminar shear strength, impact strength, Young's modulus and toughness as compared with the pure blend. Fractography analysis revealed that two different possible failure mechanisms, interface and matrix failure were apparent in the 3D printed samples with and without SEBS‐g‐MA content. This work provides a promising pathway to fabricate the complex structures from polymer blends with improved mechanical properties and surface finish.Highlights
This study demonstrated improved interlayer adhesion at the printed interface of immiscible ABS/PP blends in presence of SEBS‐g‐MA.
The printability of the developed blends was predicted from rheological properties.
Additive manufactured blends with SEBS‐g‐MA loading showed improved mechanical performance.
Social reproduction in onward migration: Colombian mothers and fathers from Spain to London
Authors: Turcatti Domiziana 
Published: June 2024

AbstractThis paper examines how social reproductive work—particularly childcare and material provision—is experienced by and distributed between fathers and mothers during onward migration. Onward migration is typically defined as the process whereby people leave their homeland, settle in a second country, and then migrate to a third country. Gendered in nature, social reproductive work refers to the activities involved in maintaining people daily and intergenerationally. Several studies explore how families' social reproductive arrangements are disrupted, reconfigured or maintained following migration. Less is known about the organisation of social reproductive labour in families who migrated multiple times. This paper draws from fieldwork with 32 Colombian mothers and 18 Colombian fathers who onward migrated from Spain to London after the 2008 crisis. Fathers typically onward migrated first to fulfil their breadwinning role, while mothers would stay in Spain to look after their children, following later. These arrangements were not necessarily maintained at the onward destination. To cope with downward mobility and precarity in London, some fathers became more involved in social reproductive work viewed as feminine (e.g., childcare), while mothers began outsourcing social reproductive tasks to better meet their families' needs and to seize the opportunities London offers. This paper suggests that onward migrant families renegotiate their social reproductive arrangements to address the socioeconomic challenges and opportunities its members encounter in the onward destination and proposes an understanding of social reproduction as relational and fluid across space and time.
Demographic, hemodynamic characteristics, and therapeutic trends of pulmonary hypertension patients: The Pulmonary Hypertension Mexican registry (REMEHIP)
Authors: Jerjes‐Sánchez Carlos , Ramírez‐Rivera Alicia , Hernandez Nayeli Zayas , Cueto Robledo Guillermo , García‐Aguilar Humberto , Gutiérrez‐Fajardo Pedro , Seoane García de León Mario , Moreno Hoyos‐Abril Francisco , Ernesto Beltrán Gámez Miguel , Elizalde Jose , Fccp Tomás Pulido , Sandoval Julio ,   The REMEHIP Investigators
Published: June 2024

AbstractData on demographic characteristics and therapeutic approaches in Latin American pulmonary arterial hypertension (PAH) patients are scarce. Pulmonary Hypertension Mexican registry (REMEHIP) is a multicenter Mexican registry of adult and pediatric patients, including prevalent and incident cases. Objective: assess clinical characteristics, treatment trends, and in‐hospital outcomes. Inclusion: age >2 years, diagnosis of pulmonary hypertension (PH) (groups 1 and 4), right heart catheterization with mPAP ≥25 mmHg, PWP ≤ 15 mmHg, and PVR > 3 Wood unit (WU). We included 875 PH patients, 619 adults, 133 pediatric idiopathic PAH (IPAH), and 123 chronic thromboembolic pulmonary hypertension (CTEPH) patients. We enrolled 48.4% of the incident and 51.6% of the prevalent adult and pediatric patients. PAH adults: age 43 ± 15, females 81.9%, functional class (FC) (I/II) 66.5%, 6‐min walk distance (6MWD) 378 ± 112 m, mPAP 57.3 ± 19.0 mmHg, confidence interval (CI) 3.3 ± 1.5 L/min/m2, PVR 12.0 ± 8.1 WU. PAH pediatrics: age 9 ± 5, females 51.1%, FC (I/II) 85.5%, 6MWD 376 ± 103 m, mPAP 49.7 ± 13.4 mmHg, CI 2.6 ± 0.9 L/min/m2, PVR 16.4 ± 13.5 WU. CTEPH: age 44 ± 17, females 56.1%, FC (I/II) 65.5%, 6MWD 369 ± 126 m, mPAP 49.7 ± 13.4 mmHg, CI 2.6 ± 0.9 L/min/m2, PVR 10.5 + 6.5 WU. When we analyzed the IPAH group separately, it sustained a high functional class I/II incidence. REMEHIP shows better functional class in young females with severe PAH than in American and European patients. Also, PAH pediatric patients had a better functional class than other registries. However, our registry also shows that our population's access to specific pharmacologic treatments is still far from optimal.
Impact of coronavirus disease 2019 on psoriatic arthritis: A multiregional observational study
Authors: Yao Ranran , Liang Renge , Lu Jing , Li Hongxia , Zhou Qiao , Li Yuhui , Xu Liling , Cheng Gong , Jia Yuan , Su Yin 
Published: June 2024

AbstractBackgroundLittle is known about the characteristics of patients with psoriatic arthritis (PsA) during the coronavirus disease 2019 (COVID‐19) pandemic. This study aimed to evaluate the impact of COVID‐19 on PsA progression and comprehend the role of COVID‐19 vaccination in the infection course.MethodsA total of 163 adult patients with PsA from 15 province‐level regions in China were enrolled in this multiregional observational study from January 14, 2023, to March 22, 2023. Data on patient demographics, COVID‐19 status, and disease characteristics were collected through a structured questionnaire survey.ResultsSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infections could worsen PsA, with 29.0% (36/124) of patients experiencing deteriorating symptoms. Psoriasis was the symptom that was most exacerbated (22, 61.1%), followed by peripheral arthritis (19, 52.8%) and dactylitis (9, 25.0%). Compared with the patients whose arthritic condition was stable before contracting COVID‐19, those with active PsA experienced more severe COVID‐19 symptoms, reporting higher self‐assessed symptom severity scores and a greater prevalence of dyspnea (42.9% [6/14] vs. 7.3% [9/123]). Moreover, although full vaccination (≥2 doses) could not prevent COVID‐19, it could alleviate the infection symptoms, including diarrhea, fatigue, appetite changes, and axial joint pain. Additionally, fully vaccinated individuals had a higher probability of avoiding deterioration of their PsA condition after infection.ConclusionsActive PsA and lack of COVID‐19 vaccination are risk factors for worsening COVID‐19 symptoms and PsA condition after infection. The evidence from this real‐world study suggests that COVID‐19 may exacerbate PsA.
Imprints of large‐scale climate oscillations on river flow in selected Canadian river catchments
Authors: Olusola Adeyemi , Ogunjo Samuel , Olusegun Christiana F. 
Published: June 2024

AbstractWe investigated the impacts of six major climate oscillations on river flow at three stations within the Humber catchments (located in Ontario, ON and Newfoundland and Labrador, NL) from 1970 to 2020 using sensitivity and wavelet analyses. Results indicate that the discharge at East Humber River near Pine (ON) exhibits the highest statistically significant sensitivity, with 0.304 and 0.394 monthly units to the Dipole Mode Index (DMI) and Tropical North Atlantic (TNA), respectively. Monthly significance analysis also highlights the diverse influence of large‐scale climate oscillations on river flow across the three locations. Wavelet analysis reveals significant active multidecadal oscillations for the North Atlantic Oscillation (NAO) at East Humber River near Pine, with high spectral power. We confirmed that stations within ON demonstrate sensitivities in a similar direction to the large‐scale climate oscillations, contrasting with those observed at NL. The observed inconsistency in the relationship between large‐scale climate oscillations and, for instance, NAO at various locations suggests that the impacts of climate oscillations may manifest differently in different regions. Overall, while inland stations exhibit similar sensitivity patterns, the coastal station demonstrates distinct responses, highlighting the importance of geographical context in understanding the impacts of large‐scale climate oscillations on river flow dynamics.
A sparse factor model for clustering high‐dimensional longitudinal data
Authors: Lu Zihang , Chandra Noirrit Kiran 
Published: June 2024

AbstractRecent advances in engineering technologies have enabled the collection of a large number of longitudinal features. This wealth of information presents unique opportunities for researchers to investigate the complex nature of diseases and uncover underlying disease mechanisms. However, analyzing such kind of data can be difficult due to its high dimensionality, heterogeneity and computational challenges. In this article, we propose a Bayesian nonparametric mixture model for clustering high‐dimensional mixed‐type (eg, continuous, discrete and categorical) longitudinal features. We employ a sparse factor model on the joint distribution of random effects and the key idea is to induce clustering at the latent factor level instead of the original data to escape the curse of dimensionality. The number of clusters is estimated through a Dirichlet process prior. An efficient Gibbs sampler is developed to estimate the posterior distribution of the model parameters. Analysis of real and simulated data is presented and discussed. Our study demonstrates that the proposed model serves as a useful analytical tool for clustering high‐dimensional longitudinal data.
Fluorine Rich Borate Salt Anion Based Electrolyte for High Voltage Sodium Metal Battery Development
Authors: Lohani Harshita , Duncan Dale T. , Qin Xueping , Kumari Pratima , Kar Mega , Sengupta Abhinanda , Ahuja Aakash , Bhowmik Arghya , Mitra Sagar 
Published: June 2024

AbstractThis study demonstrates the enhanced performance in high‐voltage sodium full cells using a novel electrolyte composition featuring a highly fluorinated borate ester anion (1 M Na[B(hfip)4].3DME) in a binary carbonate mixture (EC:EMC), compared to a conventional electrolyte (1 M Na[PF6] EC:EMC). The prolonged cycling performance of sodium metal battery employing high voltage cathodes (NVPF@C@CNT and NFMO) is attributed to uniform and dense sodium deposition along with the formation of fluorine and boron‐rich solid electrolyte interphase (SEI) on the sodium metal anode. Simultaneously, a robust cathode electrolyte interphase (CEI) is formed on the cathode side due to the improved electrochemical stability window and superior aluminum passivation of the novel electrolyte. The CEIs on high‐voltage cathodes are discovered to be abundant in C‐F, B‐O, and B‐F components, which contributes to long‐term cycling stability by effectively suppressing undesirable side reactions and mitigating electrolyte decomposition. The participation of DME in the primary solvation shell coupled with the comparatively weaker interaction between Na+ and [B(hfip)4]− in the secondary solvation shell, provides additional confirmation of labile desolvation. This, in turn, supports the active participation of the anion in the formation of fluorine and boron‐rich interphases on both the anode and cathode.
Droplet Microfluidics Powered Hydrogel Microparticles for Stem Cell‐Mediated Biomedical Applications
Authors: Zheng Fangqiao , Tian Ruizhi , Lu Hongxu , Liang Xiao , Shafiq Muhammad , Uchida Satoshi , Chen Hangrong , Ma Ming 
Published: June 2024

AbstractStem cell‐related therapeutic technologies have garnered significant attention of the research community for their multi‐faceted applications. To promote the therapeutic effects of stem cells, the strategies for cell microencapsulation in hydrogel microparticles have been widely explored, as the hydrogel microparticles have the potential to facilitate oxygen diffusion and nutrient transport alongside their ability to promote crucial cell‐cell and cell‐matrix interactions. Despite their significant promise, there is an acute shortage of automated, standardized, and reproducible platforms to further stem cell‐related research. Microfluidics offers an intriguing platform to produce stem cell‐laden hydrogel microparticles (SCHMs) owing to its ability to manipulate the fluids at the micrometer scale as well as precisely control the structure and composition of microparticles. In this review, the typical biomaterials and crosslinking methods for microfluidic encapsulation of stem cells as well as the progress in droplet‐based microfluidics for the fabrication of SCHMs are outlined. Moreover, the important biomedical applications of SCHMs are highlighted, including regenerative medicine, tissue engineering, scale‐up production of stem cells, and microenvironmental simulation for fundamental cell studies. Overall, microfluidics holds tremendous potential for enabling the production of diverse hydrogel microparticles and is worthy for various stem cell‐related biomedical applications.