bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social Problem Solving in High‐risk Mother–Child Dyads: An Intergenerational Study
Authors: Martin Julie P. , Stack Dale M. , Serbin Lisa A. , Schwartzman Alex E. , Ledingham Jane 
Published: December 2011

AbstractThis study examined the contribution of maternal childhood histories of aggression and social withdrawal to the prediction of mother–child social problem solving in the next generation. Fifty‐seven women (M = 37.32 years), previously rated (on a version of the pupil evaluation inventory) by their peers during childhood on measures of aggression and withdrawal, discussed conflicts with their 9‐ to 13‐year‐old children. Problem‐defining statements, solutions, and resolution strategies were coded using an observational measure developed by the authors. Maternal childhood histories of aggression and withdrawal predicted poorly sophisticated solutions in both mothers and children as well as antisocial solutions in children. Histories of withdrawal predicted solitary solutions in children as well as less guidance and structure during decision making. Findings suggest that mothers who were withdrawn, and those aggressive and withdrawn in childhood, display less sophisticated problem solving, which may be mirrored in children. Results have implications for the development of aggressive and withdrawn girls into parenthood and highlight a potential pathway for the transfer of risk.
Headache Following Intracranial Neuroendovascular Procedures
Authors: Baron Eric P. , Moskowitz Shaye I. , Tepper Stewart J. , Gupta Rishi , Novak Eric , Hussain Muhammad Shazam , Stillman Mark J. 
Published: December 2011

(Headache 2012;52:739‐748)Aims.— Predicting who will develop post‐procedure headache (PPH) following intracranial endovascular procedures (IEPs) would be clinically useful and potentially could assist in reducing the excessive diagnostic testing so often obtained in these patients. Although limited safety data exist, the use of triptans or dihydroergotamine (DHE) often raise concern when used with pre/post‐coiled aneurysms. We sought to determine risk factors for PPH following IEP, to evaluate the utility of diagnostic testing in patients with post‐coil acute headache (HA), and to record whether triptans and DHE have been used safely in this clinical setting.Methods.— We conducted a retrospective chart review of adult patients undergoing IEPs. Bivariate analyses were conducted to compare patients who did and did not develop PPH.Results.— We reviewed records pertaining to 372 patients, of whom 263 underwent intracranial coil embolizations, 21 acrylic glue embolizations, and 88 stent placements. PPH occurred in 72% of coil patients, 33% of glue patients, and 14% of stent patients. Significant risk factors for post‐coil HA were female gender, any pre‐coil HA history, smoking, and anxiety/depression. A pre‐stent history of HA exceeding 1 year's duration, and smoking were risk factors for post‐stent HA. A pre‐glue history of HA exceeding 1 year was the only risk factor for post‐glue HA. In the small subgroup available for study, treatment with triptans or DHE was not associated with adverse events in pre/post‐coiled aneurysms. Diagnostic testing was low yield.Conclusions.— Occurrence of PPH was common after IEPs and especially so with coiling and in women, smokers, and those with anxiety/depression, and was often of longer duration than allowed by current International Classification of Headache Disorders‐II criteria. The yield of diagnostic testing was low, and in a small subgroup treatment with triptans or DHE did not cause adverse events in pre/post‐coiled aneurysms. Prospective studies are needed to confirm these findings.
Partial Excision of
bla
KPC
from Tn
4401
in Carbapenem-Resistant Klebsiella pneumoniae
Authors: Chen Liang , Chavda Kalyan D. , Mediavilla José R. , Jacobs Michael R. , Levi Michael H. , Bonomo Robert A. , Kreiswirth Barry N. 
Published: December 2011

ABSTRACT

We describe a novel Tn
4401
variant (Tn
4401d
) in epidemic
Klebsiella pneumoniae
clone ST258, from which a partial
bla
KPC
fragment has been excised along with IS
Kpn7
and a partial
tnpA
fragment. Nested-PCR experiments confirmed that this region can be removed from distinct Tn
4401
isoforms in both
K. pneumoniae
and
Escherichia coli
. This study highlights that the region surrounding
bla
KPC
is undergoing recombination and that Tn
4401
itself is heterogeneous and highly plastic.
Inner Ear Effects of Canal Wall Down Mastoidectomy
Authors: Leonetti John P. , Kircher Matthew L. , Jaber James J. , Benscoter Brent J. , Marmora Joseph J. , Feustel Paul J. 
Published: December 2011

ObjectiveTo evaluate the inner ear effects of canal wall down (CWD) mastoidectomy without ossiculoplasty in the treatment of chronic otitis media (COM) with regard to sensorineural hearing loss (SNHL) and reported tinnitus and dizziness‐related disability.SettingTertiary care academic medical center.Subjects and MethodsProspective study of 86 patients treated by CWD mastoidectomy without ossiculoplasty for COM with or without cholesteatoma. Standard patient workup included preoperative audiogram and completion of 2 surveys: Dizziness Handicap Inventory (DHI) and Tinnitus Handicap Inventory (THI). Patients underwent repeat audiogram, DHI, and THI surveys at 4 to 6 months postoperatively. Preoperative and postoperative data were analyzed.ResultsNo significant SNHL occurred after CWD mastoidectomy. Thirteen patients (13/34 [38%]) had DHI improvement greater than 18 points, indicating a significant improvement in dizziness‐related disability. Three patients developed new‐onset postoperative dizziness complaints. Twenty patients (20/43 [46.5%]) had THI improvement greater than 7 points, indicating a significant improvement in tinnitus‐related disability. Five patients developed new‐onset postoperative tinnitus complaints. The odds ratio for improving DHI and THI scores after surgery was 6.6 (1.8 to 25.0) and 4.2 (95% confidence interval, 1.45% to 12.2%), respectively.ConclusionIn this study, CWD mastoidectomy without ossiculoplasty in the treatment of COM did not cause significant SNHL. In addition, using the DHI and THI measures, patient‐perceived disability from dizziness and tinnitus, respectively, was shown to decrease after mastoid surgery.
Clinical characteristics and prognosis of acute bacterial meningitis in elderly patients over 65: a hospital-based study
Authors: Lai Wei-An , Chen Shu-Fang , Tsai Nai-Wen , Chang Chiung-Chih , Chang Wen-Neng , Lu Cheng-Hsien , Chuang Yao-Chung , Chien Chun-Chih , Huang Chi-Ren 
Published: December 2011

Abstract

Background
To examine the clinical characteristics of bacterial meningitis in elderly patients.

Methods
261 patients with adult bacterial meningitis (ABM), collected during a study period of 11 years (2000-2010), were included for study. Among them, 87 patients aged ≥ 65 years and were classified as the elderly group. The clinical and laboratory characteristics and prognostic factors were analyzed, and a clinical comparison with those of non-elderly ABM patients was also made.

Results
The 87 elderly ABM patients were composed of 53 males and 34 females, aged 65-87 years old (median = 71 years). Diabetes mellitus (DM) was the most common underlying condition (34%), followed by end stage renal disease (7%), alcoholism (4%) and malignancies (4%). Fever was the most common clinical manifestation (86%), followed by altered consciousness (62%), leukocytosis (53%), hydrocephalus (38%), seizure (30%), bacteremia (21%) and shock (11%). Thirty-nine of these 87 elderly ABM patients had spontaneous infection, while the other 48 had post-neurosurgical infection. Forty-four patients contracted ABM in a community-acquired state, while the other 43, a nosocomial state. The therapeutic results of the 87 elderly ABM patients were that 34 patients expired and 53 patients survived. The comparative results of the clinical and laboratory characteristics between the elderly and non-elderly ABM patients showed that only peripheral blood leukocytosis was significant. Presence of shock and seizure were significant prognostic factors of elderly ABM patients.

Conclusions
Elderly ABM patients accounted for 34.8% of the overall ABM cases, and this relatively high incidence rate may signify the future burden of ABM in the elderly population in Taiwan. The relative frequency of implicated pathogens of elderly ABM is similar to that of non-elderly ABM. Compared with non-elderly patients, the elderly ABM patients have a significantly lower incidence of peripheral blood leukocytosis. The mortality rate of elderly ABM remains high, and the presence of shock and seizures are important prognostic factors.
Primary hyperparathyroidism diagnosed after surgical ablation of a costal mass mistaken for giant-cell bone tumor: a case report
Authors: Vera Lara , Dolcino Mara , Mora Marco , Oddo Silvia , Gualco Marina , Minuto Francesco , Giusti Massimo 
Published: December 2011

Abstract

Introduction
Primary hyperparathyroidism is a common endocrine disorder characterized by elevated parathyroid hormone levels, which cause continuous osteoclastic bone resorption. Giant cell tumor of bone is an expansile osteolytic tumor that contains numerous osteoclast-like giant cells. There are many similarities in the radiological and histological features of giant cell tumor of bone and brown tumor. This is a rare benign focal osteolytic process most commonly caused by hyperparathyroidism.

Case presentation
We report the unusual case of a 40-year-old Caucasian woman in which primary hyperparathyroidism was diagnosed after surgical ablation of a costal mass. The mass was suspected of being neoplastic and histopathology was compatible with a giant cell tumor of bone. On the basis of the biochemical results (including serum calcium, phosphorous and intact parathyroid hormone levels) primary hyperparathyroidism was suspected and a brown tumor secondary to refractory hyperparathyroidism was diagnosed.

Conclusions
Since giant cell tumor is a bone neoplasm that has major implications for the patient, the standard laboratory tests in patients with bone lesions are important for a correct diagnosis.
Activation of Peripheral-Blood Granulocytes Is Strongly Correlated With Patient Outcome After Immunotherapy With Anti-GD2 Monoclonal Antibody and Granulocyte-Macrophage Colony-Stimulating Factor
Authors: Cheung Irene Y. , Hsu Katharine , Cheung Nai-Kong V. 
Published: December 2011

PurposeAdjuvant therapy using anti-GD2 monoclonal antibody and granulocyte-macrophage colony-stimulating factor (GM-CSF) has shown treatment success for patients with high-risk neuroblastoma (NB). Although there is ample evidence on how the antibody targets NB, in vivo contribution by GM-CSF remains unclear. This report investigates granulocyte activation and its correlation with treatment outcome.Patients and MethodsPatients enrolled onto NCT00072358 received multiple treatment cycles, each consisting of anti-GD2 antibody 3F8 plus subcutaneous (SC) GM-CSF. Peripheral-blood (PB) samples from 151 patients were collected on day 0 and day 4 of cycle 1. PB from a subgroup of 35 patients had intravenous (IV) instead of SC GM-CSF during cycle 4. Samples were analyzed by flow cytometry for CD11a, CD63, CD87, and CD11b and its activation epitope CBRM1/5.ResultsComparing cycle 1 day 4 PB samples with day 0 PB samples, five of five activation marker–positive granulocytes were significantly higher. The change in frequency and mean fluorescence intensity of CBRM1/5-positive granulocytes correlated with progression-free survival (PFS; P = .024 and P = .008, respectively). A multivariable analysis identified increasing CBRM1/5-positive granulocytes and missing killer immunoglobulin-like receptor ligand as positive independent prognostic factors for PFS, whereas second-line cyclophosphamide-based therapy before protocol entry negatively influenced outcome. Thirty-five patients who received SC GM-CSF at cycle 1 and IV GM-CSF at cycle 4 had significantly less CBRM1/5 activation after IV GM-CSF. In contrast, 63 patients who received SC GM-CSF at both cycles had comparable CBRM1/5 activation.ConclusionGM-CSF–induced granulocyte activation in vivo is associated with improved patient outcome. This activation was more apparent when GM-CSF was given by the SC route instead of IV route.
Endocranial petrosal anatomy ofBothriogenys(Mammalia, Artiodactyla, Anthracotheriidae), and petrosal volume and density comparisons among aquatic and terrestrial artiodactyls and outgroups
Authors: O'Leary Maureen A. , Patel Biren A. , Coleman Mark N. 
Published: December 2011

We provide the first detailed endocranial description of the petrosal bone of the ear region of the anthracotheriid artiodactylBothriogenys, based on two new specimens from the early Oligocene of the Jebel Qatrani Formation, Fayum, Egypt. The new fossils have petrosals with a hyperinflated (pachyostotic) tegmen tympani (the roof over the middle ear), resembling the condition in certain cetancodontans such as hippopotamids and basal cetaceamorphans (fossil stem taxa to extant Cetacea).The morphology of the petrosal, particularly its relative size and density, has been considered an important indicator of the ability of a marine mammal to localize sound transmitted in water, yet petrosal size (pachyostosis) and density (osteosclerosis) have not previously been quantified independent of each other. We examine the new fossils in the context of a preliminary CT-based study of petrosal density (extant taxa only) and petrosal volume (extant and extinct taxa) in a sample of artiodactyls and outgroups. In our extant comparative sample, the petrosals of cetaceans are both dense and voluminous as has been previously stated. We find, however, that the tegmen tympani is relatively voluminous (pachyostotic) without being particularly dense (osteosclerotic) inHippopotamus amphibius, an extant taxon that has been documented to show some aquatic hearing behaviors, albeit less derived ones than those seen in cetaceans. A voluminous tegmen tympani, which is present inBothriogenys, may have specific implications for behavior that are distinct from increases in petrosal density.
Surface-Area vs. Conductivity-Type Fracture Treatments in Shale Reservoirs
Authors: Ramurthy Muthukumarappan , Barree Robert D. , Kundert Donald P. , Petre Erik , Mullen Mike 
Published: December 2011

Summary
Hydraulic fracturing continues to be the primary mechanism to produce hydrocarbons out of tight shale reservoirs. Ever since the success of the Barnett shale program, operators are inclined to pump similar large-volume water-fracture (waterfrac) treatments with little or no proppant in their respective shale plays. This assumes that all shale plays are the same and react accordingly to large-volume treatments. The basic objective behind such treatments is to contact large surface area, which has been very successful in the Barnett shale play. Such large-volume treatments in other shale plays may not be an optimized solution for the specific shale attributes, and the response may lead to uneconomical production results. Some shales might require a conductivity fracture treatment on the basis of their reservoir characteristics. So, it is important to understand the characteristics of these shales before deciding on the stimulation treatments. In addition to core and log analysis of these shales, fluid-sensitivity tests, Brinell hardness (BHN) tests, unpropped-fracture-conductivity tests, and, more importantly, a diagnostic fracture injection test (DFIT) can help define the guidelines for choosing between a surface-area and a conductivity-type fracture treatment.
Integrating the various data sources is important in arriving at these guidelines. The main objective of this paper is to provide these guidelines along with examples so that a costly trial-and-error approach for stimulating shales can be avoided. Examples from both oil and gas shales (i.e., the Gothic, Haynesville, Eagle Ford, and Barnett shale plays in the USA) are included in this work.
Experimental Evaluation of Guar-Fracture-Fluid Filter-Cake Behavior
Authors: Xu Ben , Hill A.D.. D. , Zhu Ding , Wang Lei 
Published: December 2011

Summary
Guar gum and its derivatives have been the most commonly used polymers to increase the viscosity of fracturing fluids. However, the conductivity of many fractures created with guar-based polymers is low because of residual unbroken polymer gel remaining in the fracture. This residue can cause permeability impairment in the proppant pack, resulting in low fracture conductivity and decreased effective fracture length. In this study, we experimentally evaluated two important aspects of the gel damage process—the thickness of the polymer-gel filter cake that is created as fracture-fluid filtrate leaks off into the formation and the yield stress of the concentrated polymer gel that accumulates in the fracture. The thickness of the filter cake created during the leakoff process was measured as a function of the polymer loading and the volume of leakoff. We created the filter cake following the procedure described by Ayoub et al. (2006) and then measured the filter-cake thickness with a precise laser profilometer. We found that the filter-cake thickness varied linearly with leakoff volume, meaning that the gel concentration factor is constant for this guar polymer fluid. The concentrated polymer filter cakes created by leakoff behave rheologically as Herschel-Bulkley fluids having a yield stress. The yield stress of this material is a critical parameter influencing whether the gel can be removed from the fracture. We measured the yield stress of borate-crosslinked guar polymer fracture fluids at concentrations up to 200 lbm/1,000 gals by use of a unique flat-plate device. The yield stresses of the polymer filter cakes were found to depend strongly on the concentration of both polymer and breaker.
World's Deepest Through-Tubing Electrical Submersible Pumps
Authors: Julian J.Y.. Y. , Patterson J.C.. C. , Yingst B.E.. E. , Dinkins W.R.. R. 
Published: December 2011

Summary
This paper describes the development, history, and successful deployment of the world's two deepest through-tubing-conveyed electrical submersible pumps (TTCESPs). These are the first TTCESPs deployed inside of 7-in. casing. Electrical submersible pumps (ESPs) are a form of artificial lift that consists of a pump, motor, and electric cable, typically deployed by a rig and connected to electric power at surface. Their advantage is that they create greater drawdown than other forms of artificial lift, thus achieving higher production rates. However, conventional ESPs require expensive workover rigs to replace pumps, the component that fails most frequently. ConocoPhillips Alaska developed TTCESP technology to replace failed pumps rapidly and economically. In this system, a rig conventionally deploys the electric cable, motor, and seal sections with a special latching device for the pump. The pump is pulled and replaced with slickline (wireline) or coiled tubing, eliminating the requirement of a rig.
The original through-tubing-conveyed (TTC) systems were developed for 7⅝-in.-cased wells. During approximately the past 10 years, it was common belief that they could not be deployed at the Milne Point field in Alaska because of the limitations of its smaller wells (7-in., 26-lbm/ft casing). This paper discusses the enabling technologies that were developed to allow running TTCESPs in 7-in. casing, including a wellhead spoolpiece and low-clearance ESP clamps.
West Sak TTCESP run-time data indicate that the time between rig workovers (RWOs) will increase from 3.5 to 6 years. Pumps can be replaced for 5–10% of rig costs without the safety and environmental impacts associated with rigs. Additionally, production impacts while waiting for a rig are eliminated because slickline and coiled-tubing units are readily available on the North Slope of Alaska. TTC pumps can easily be upsized or downsized to optimize pump flow rate because of changes in production rates. This technology is of interest in areas where rig costs are high, including Arctic, remote, and offshore locations. It is also beneficial where rig availability is low.
A New Proprietary Hybrid-Solvent Process for Improved Mercaptan Removal
Authors: Cadours Renaud , Shah Virenkumar , Weiss Claire 
Published: December 2011

Summary
Removing mercaptans from sour natural gas has always been considered a challenge. This is becoming an even more important issue with the global trend toward more-stringent specifications for commercial gases.
Amines have been used extensively because of their ability to meet the most severe H2S and CO2 specifications and their very high acid-gas selectivity over hydrocarbons, but they present very limited mercaptans-removal performances. They require an additional treatment step to achieve the total sulfur-content specification in the exported gas. Hybrid solvents are more efficient in removing mercaptans but have the disadvantage of poor acid-gas selectivity over hydrocarbons, resulting in hydrocarbon losses with the separated acid gases.
Total, taking advantage of its extensive knowledge and experience in acid-gas removal with amine mixtures, has developed a new proprietary hybrid-solvent formulation allowing simultaneous absorption of acid gases and of mercaptans, with limited coabsorption of hydrocarbons. (The new hybrid solvent process is Total's proprietary process known as the HySWEET® process, which is a registered trademark.) The solvent was selected at the laboratory scale, with a particular attention given to operation-related constraints (e.g., cost, corrosion, foaming, degradation). The new solvent's acid-gas- and mercaptans-removal performances were then validated on a pilot rig.
The performance of the process has been assessed for several field applications and compared with the performances of conventional amine processes. This allowed evaluating the potential gain achievable by the implementation of the new hybrid solvent. The study identifies the application cases for which the new hybrid solvent will allow an economic and complete mercaptan removal without any additional treatment and identifies the perspective reduction of these additional treatments for the other cases. Besides an economical mercaptan removal, the new hybrid solvent allows a significant reduction in the energy consumption.
The results of the technoeconomic evaluation of the process have been confirmed during the first successful industrial application at the Lacq sour-gas plant in 2008. Half of the gas production is now treated with the hybrid solvent, allowing the plant to achieve high global mercaptans removal.
These results are fully documented in the paper, demonstrating that the newly developed process is a good contender for the development of new sour-gas fields to achieve the increasingly stringent commercial gas specifications.