bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Virus-Like Particle-Based Anti-Nerve Growth Factor Vaccine Reduces Inflammatory Hyperalgesia: Potential Long-Term Therapy for Chronic Pain
Authors: Röhn Till A. , Ralvenius William T. , Paul Jolly , Borter Petra , Hernandez Marcela , Witschi Robert , Grest Paula , Zeilhofer Hanns Ulrich , Bachmann Martin F. , Jennings Gary T. 
Published: December 2010

Abstract
Chronic pain resulting from inflammatory and neuropathic disorders causes considerable economic and social burden. For a substantial proportion of patients, conventional drug treatments do not provide adequate pain relief. Consequently, novel approaches to pain management, involving alternative targets and new therapeutic modalities compatible with chronic use, are being sought. Nerve growth factor (NGF) is a major mediator of chronic pain. Clinical testing of NGF antagonists is ongoing, and clinical proof of concept has been established with a neutralizing mAb. Active immunization, with the goal of inducing therapeutically effective neutralizing autoreactive Abs, is recognized as a potential treatment option for chronic diseases. We have sought to determine if such a strategy could be applied to chronic pain by targeting NGF with a virus-like particle (VLP)-based vaccine. A vaccine comprising recombinant murine NGF conjugated to VLPs from the bacteriophage Qβ (NGFQβ) was produced. Immunization of mice with NGFQβ induced anti-NGF–specific IgG Abs capable of neutralizing NGF. Titers could be sustained over 1 y by periodic immunization but declined in the absence of boosting. Vaccination with NGFQβ substantially reduced hyperalgesia in collagen-induced arthritis or postinjection of zymosan A, two models of inflammatory pain. Long-term NGFQβ immunization did not change sensory or sympathetic innervation patterns or induce cholinergic deficits in the forebrain, nor did it interfere with blood-brain barrier integrity. Thus, autovaccination targeting NGF using a VLP-based approach may represent a novel modality for the treatment of chronic pain.
Diverse Endogenous Antigens for Mouse NKT Cells: Self-Antigens That Are Not Glycosphingolipids
Authors: Pei Bo , Speak Anneliese O. , Shepherd Dawn , Butters Terry , Cerundolo Vincenzo , Platt Frances M. , Kronenberg Mitchell 
Published: December 2010

Abstract
NKT cells with an invariant Ag receptor (iNKT cells) represent a highly conserved and unique subset of T lymphocytes having properties of innate and adaptive immune cells. They have been reported to regulate a variety of immune responses, including the response to cancers and the development of autoimmunity. The development and activation of iNKT cells is dependent on self-Ags presented by the CD1d Ag-presenting molecule. It is widely believed that these self-Ags are glycosphingolipids (GSLs), molecules that contain ceramide as the lipid backbone. In this study, we used a variety of methods to show that mammalian Ags for mouse iNKT cells need not be GSLs, including the use of cell lines deficient in GSL biosynthesis and an inhibitor of GSL biosynthesis. Presentation of these Ags required the expression of CD1d molecules that could traffic to late endosomes, the site where self-Ag is acquired. Extracts of APCs contain a self-Ag that could stimulate iNKT cells when added to plates coated with soluble, rCD1d molecules. The Ag(s) in these extracts are resistant to sphingolipid-specific hydrolase digestion, consistent with the results using live APCs. Lyosphosphatidylcholine, a potential self-Ag that activated human iNKT cell lines, did not activate mouse iNKT cell hybridomas. Our data indicate that there may be more than one type of self-Ag for iNKT cells, that the self-Ags comparing mouse and human may not be conserved, and that the search to identify these molecules should not be confined to GSLs.
IL-1α Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil
Authors: Lee Pui Y. , Kumagai Yutaro , Xu Yuan , Li Yi , Barker Tolga , Liu Chao , Sobel Eric S. , Takeuchi Osamu , Akira Shizuo , Satoh Minoru , Reeves Westley H. 
Published: December 2010

Abstract
Exposure to naturally occurring hydrocarbon oils is associated with the development of chronic inflammation and a wide spectrum of pathological findings in humans and animal models. The mechanism underlying the unremitting inflammatory response to hydrocarbons remains largely unclear. The medium-length alkane 2,6,10,14 tetramethylpentadecane (also known as pristane) is a hydrocarbon that potently elicits chronic peritonitis characterized by persistent infiltration of neutrophils and monocytes. In this study, we reveal the essential role of IL-1α in sustaining the chronic recruitment of neutrophils following 2,6,10,14 tetramethylpentadecane treatment. IL-1α and IL-1R signaling promote the migration of neutrophils to the peritoneal cavity in a CXCR2-dependent manner. This mechanism is at least partially dependent on the production of the neutrophil chemoattractant CXCL5. Moreover, although chronic infiltration of inflammatory monocytes is dependent on a different pathway requiring TLR-7, type I IFN receptor, and CCR2, the adaptor molecules MyD88, IL-1R–associated kinase (IRAK)-4, IRAK-1, and IRAK-2 are shared in regulating the recruitment of both monocytes and neutrophils. Taken together, our findings uncover an IL-1α–dependent mechanism of neutrophil recruitment in hydrocarbon-induced peritonitis and illustrate the interactions of innate immune pathways in chronic inflammation.
T Cell-Intrinsic Factors Contribute to the Differential Ability of CD8+ T Cells To Rapidly Secrete IFN-γ in the Absence of Antigen
Authors: Bou Ghanem Elsa N. , Nelson Christina C. , D’Orazio Sarah E. F. 
Published: December 2010

Abstract
A subset of CD44hiCD8+ T cells isolated from C57BL/6/J (B6) mice, but not BALB/c/By/J (BALB/c) mice, rapidly secrete IFN-γ within 16 h of infection with Listeria monocytogenes. This Ag-independent response requires the presence of both IL-12 and IL-18. Previous studies showed that dendritic cells from B6 mice produced more Th1-type cytokines such as IL-12 than did those from BALB/c mice in response to L. monocytogenes infection. In this report, we demonstrate that the microenvironment in L. monocytogenes-infected BALB/c mice is sufficient to induce responsive B6 CD8+ T cells to rapidly secrete IFN-γ. Furthermore, BALB/c CD8+ T cells did not rapidly secrete IFN-γ even when they were exposed to high concentrations of IL-12 plus IL-18 in vitro. In the presence of IL-12 and IL-18, B6 CD44hiCD8+ T cells upregulated expression of the receptor subunits for these cytokines more rapidly than did BALB/c T cells. In comparing particular subsets of memory phenotype CD8+ T cells, we found that virtual memory cells, rather than true Ag-experienced cells, had the greatest level of impairment in BALB/c mice. These data suggest that the degree of cytokine-driven bystander activation of CD8+ T cells that occurs during infection depends on both APCs and T cell-intrinsic properties that can vary among mouse strains.
Asymptotic Analysis of Lattice Boltzmann Outflow Treatments
Authors: Junk Michael , Yang Zhaoxia 
Published: December 2010

AbstractWe show the methodology and advantages of asymptotic analysis when applied to lattice Boltzmann outflow treatments. On the one hand, one can analyze outflow algorithms formulated directly in terms of the lattice Boltzmann variables, like the extrapolation method, to find the induced outflow conditions in terms of the Navier-Stokes variables. On the other hand, one can check the consistency and accuracy of lattice Boltzmann outflow treatments to given hydrodynamic outflow conditions like the Neumann or average pressure condition. As example how the gained insight can be used, we propose an improvement of the well known extrapolation method.
Get Moving: A Web Site That Increases Physical Activity of Sedentary Employees
Authors: Irvine A. Blair , Philips Laura , Seeley John , Wyant Sara , Duncan Susan , Moore Roger W. 
Published: December 2010

Purpose. Develop and test a Web site to encourage physical activity (PA) by sedentary workers. Design. Randomized control design with 30-day follow-up. Setting. Large manufacturing plant. Subjects. Included 221 workers; average body mass index was 29.5. Intervention. Get Moving was a repeat-visit Web site providing information and support to develop a personalized PA plan. Measures. Self-reported: PA, depression, anxiety, stage of change, attitudes, knowledge, self-efficacy, intention, perceived barriers to PA, and motivation. Analysis. Multivariate analysis of covariance and univariate analysis of covariance models were used to compare the two study conditions on posttest outcomes, controlling for baseline levels. Results. Compared with the control group, the treatment group showed significant improvement. The multivariate test was significant (p < .001), with a large effect size (η2 = .42). The treatment group differed significantly from the control participants on 11 outcomes (p < .005), with large effect sizes for PA status, min/d, and knowledge, attitudes, and behavioral intention. Medium effect sizes were measured for perceived barriers, depressive symptoms, motivation, and self-efficacy. Multiple visits resulted in significantly improved PA, motivation, self-efficacy, and intention, compared with one-time visits. Conclusions. The Get Moving Web site had positive effects and was well received. Interventions Web site have potential to increase the PA of sedentary individuals in worksites and elsewhere, but more research is needed into mediators of Web-based interventions. (Am J Health Promot 2011;25[3]:199–206.)
A Faith-Based Physical Activity Intervention for Latinos: Outcomes and Lessons
Authors: Bopp Melissa , Fallon Elizabeth A. , Marquez David X. 
Published: December 2010

Purpose. To develop, implement, and evaluate a pilot faith-based physical activity (PA) intervention for Latinos. Design. Randomized trial, with two churches receiving the intervention and one church serving as a comparison group. Setting. Three Catholic churches near Manhattan, Kansas. Subjects. A subsample of the congregation from the intervention churches (n = 24) and comparison church (n = 23) volunteered to take part in the assessment. Intervention. Culturally and spiritually relevant education materials and activities were developed promoting the health benefits of PA. Educational materials included flyers, bulletin inserts, and posters. An 8-week team based walking contest promoted social support for PA. A health “fiesta” provided hands-on educational opportunities for PA. Measures. Organizational and individual process evaluation outcomes were assessed at baseline and 6 months. Interviews with church contacts at 6 months documented successes and struggles with implementation. Individual-level variables assessed knowledge related to PA and exposure to the intervention. Analysis. Basic frequencies and descriptive statistics were used. Results. Compared with 36% of comparison participants, 66% of intervention participants identified health reasons for participating in PA, and 47% accurately described PA recommendations, compared with 16% of comparison participants. Process evaluation revealed implementation successes and struggles, including communication problems with church contacts and difficulty in creating a large exposure to intervention materials. Conclusions. This pilot study provides formative research for developing larger faith-based PA interventions targeting Latinos. (Am J Health Promot 2011;25[3]:168–171.)
Workplace Telecommunications Technology to Identify Mental Health Disorders and Facilitate Self-Help or Professional Referrals
Authors: Farzanfar Ramesh , Locke Steven E. , Heeren Timothy C. , Stevens Allison , Vachon Louis , Nguyen Mai Khoa Thi , Friedman Robert H. 
Published: December 2010

Purpose. Test the feasibility and impact of an automated workplace mental health assessment and intervention. Design. Efficacy was evaluated in a randomized control trial comparing employees who received screening and intervention with those who received only screening. Setting. Workplace. Subjects. 463 volunteers from Boston Medical Center, Boston University, and EMC and other employed adults, among whom 164 were randomized to the intervention (N = 87) and control (N = 77) groups. Intervention. The system administers a panel of telephonic assessment instruments followed by tailored information, education, and referrals. Measures. The Work Limitation Questionnaire, the Medical Outcomes Questionnaire Short Form-12, the Patient Health Questionnaire-9, question 10 from the Patient Health Questionnaire to measure functional impairment, and the Perceived Stress Scale-4 and questions written by study psychiatrists to measure emotional distress and social support respectively. The WHO-Five Well-being Index was administered to measure overall well-being. Analysis. Independent sample t-tests and χ2 tests as well as mean change were used to compare the data. Results. No significant differences on 16 of the 20 comparisons at 3- and 6-month time points. The intervention group showed a significant improvement in depression (p ≤ .05) at 3 months and on two Work Limitation Questionnaire subscales, the Mental-Interpersonal Scale (p ≤ .05) and the Time and Scheduling Scale (p ≤ .05), at 3 and 6 months respectively with a suggestive improvement in mental health at 6 months (p ≤ .10). Conclusions. This is a potentially fruitful area for research with important implications for workplace behavioral interventions. (Am J Health Promot 2011;25[3]:207–216.)
Metal‐Organic Frameworks: Metal‐Organic Frameworks: A Rapidly Growing Class of Versatile Nanoporous Materials (Adv. Mater. 2/2011)
Authors: Meek Scott T. , Greathouse Jeffery A. , Allendorf Mark D. 
Published: December 2010

AbstractMetal‐organic frameworks (MOFs) represent a new class of hybrid organic‐inorganic supramolecular materials comprised of ordered networks formed from organic electron donor linkers and metal cations. They can exhibit extremely high surface areas, as well as tunable pore size and functionality, and can act as hosts for a variety of guest molecules. Since their discovery, MOFs have enjoyed extensive exploration, with applications ranging from gas storage to drug delivery to sensing. This review covers advances in the MOF field from the past three years, focusing on applications, including gas separation, catalysis, drug delivery, optical and electronic applications, and sensing. We also summarize recent work on methods for MOF synthesis and computational modeling.
Magnetite (Fe3O4) Nanoparticles‐Catalyzed Sonogashira– Hagihara Reactions in Ethylene Glycol under Ligand‐Free Conditions
Authors: Firouzabadi Habib , Iranpoor Nasser , Gholinejad Mohammad , Hoseini Jafar 
Published: December 2010

AbstractA novel application of nanoparticles of paramagnetic magnetite (Fe3O4) as an efficient catalyst for carbon‐carbon bond formation via the Sonogashira–Hagihara reaction under heterogeneous ligand‐free conditions in ethylene glycol (EG) is described. By using this catalyst, arylalkynes are produced from the reaction of aryl iodides and activated heteroaryl bromides with alkynes. The results are reproducible using the catalyst, which was prepared from different sources. The catalyst is easily separated by an external magnetic field from the reaction mixture. The separated catalyst can be recycled for several consecutive runs without appreciable loss of its catalytic activity.
Polyheterocycles by Palladium(II)‐Catalyzed Oxidative Domino Reactions Involving Direct CH Functionalization
Authors: Liu Renrong , Zhang Junliang 
Published: December 2010

AbstractA novel palladium(II)‐catalyzed oxidative domino reaction sequence of diyne‐enones and substituted indoles to afford polyheterocycles involving direct CH functionalization using air as oxidant has been developed.
Proline‐Derived Aminotriazole Ligands: Preparation and Use in the Ruthenium‐Catalyzed Asymmetric Transfer Hydrogenation
Authors: Cambeiro Xacobe C. , Pericàs Miquel A. 
Published: December 2010

AbstractThe preparation of 2‐triazolyl‐ and 2‐triazolylmethylpyrrolidines from L‐proline and L‐trans‐4‐hydroxyproline is described, along with their evaluation as chiral ligands in ruthenium‐catalyzed asymmetric transfer hydrogenation. Modular evolution of the ligands by introduction of remote substituents is also presented, showing a surprisingly important effect on the performance of the ligands.
Hydroxylamine as a Source for Nitric Oxide in Metal‐Free 2,2,6,6‐ Tetramethylpiperidine N‐Oxyl Radical (TEMPO) Catalyzed Aerobic Oxidation of Alcohols
Authors: Wertz Sebastian , Studer Armido 
Published: December 2010

AbstractThe communication reports on the metal‐free 2,2,6,6‐tetramethylpiperidine N‐oxyl radical (TEMPO) catalyzed aerobic oxidation of various alcohols to aldehydes and ketones. A novel catalyst system that uses 1–4 mol% of TEMPO in combination with 4–6 mol% of aqueous hydroxylamine is introduced. No other additives are necessary and corrosive by‐products are not formed during oxidation. Nitric oxide which is important for the catalytic cycle is generated in situ by reaction of the hydroxylamine with TEMPO. A catalytic cycle for the overall oxidation process is suggested.
Metal‐Air Batteries: Metal–Air Batteries with High Energy Density: Li–Air versus Zn–Air (Adv. Energy Mater. 1/2011)
Authors: Lee Jang‐Soo , Tai Kim Sun , Cao Ruiguo , Choi Nam‐Soon , Liu Meilin , Lee Kyu Tae , Cho Jaephil 
Published: December 2010

AbstractIn the past decade, there have been exciting developments in the field of lithium ion batteries as energy storage devices, resulting in the application of lithium ion batteries in areas ranging from small portable electric devices to large power systems such as hybrid electric vehicles. However, the maximum energy density of current lithium ion batteries having topatactic chemistry is not sufficient to meet the demands of new markets in such areas as electric vehicles. Therefore, new electrochemical systems with higher energy densities are being sought, and metal‐air batteries with conversion chemistry are considered a promising candidate. More recently, promising electrochemical performance has driven much research interest in Li‐air and Zn‐air batteries. This review provides an overview of the fundamentals and recent progress in the area of Li‐air and Zn‐air batteries, with the aim of providing a better understanding of the new electrochemical systems.
Involvement of the cerebellothalamocortical pathway in Parkinson disease
Authors: Ni Zhen , Pinto Andrew D. , Lang Anthony E. , Chen Robert 
Published: December 2010

AbstractObjectiveLesioning or stimulation of the cerebellar thalamus is an established treatment for rest and postural tremors in Parkinson disease (PD). The cerebellothalamocortical (CTC) pathway can be assessed by transcranial magnetic stimulation (TMS) of the cerebellum, which suppresses the contralateral primary motor cortex (M1), a phenomenon termed cerebellar inhibition (CBI). Tremor reset can be used to assess whether the stimulated brain area is involved in the generation or transmission of tremor. We tested whether M1 or cerebellar stimulation can reset PD tremor, and investigated the excitability of the CTC pathway in PD.MethodsTen mild to moderate PD patients in the OFF medication state and 10 healthy controls were studied. Tremor reset was tested with TMS delivered to the cerebellum or M1. CBI was assessed by cerebellar stimulation followed by M1 stimulation at interstimulus intervals of 3 to 8 milliseconds. Subjects were tested both at rest and during arm extension.ResultsRest tremor in PD was reset by M1 stimulation but not by cerebellar stimulation. Postural tremor was reset by both types of stimulation. At rest, CBI was reduced in PD patients compared to controls. Arm extension decreased CBI in controls and turned the inhibition into facilitation in patients. CBI correlated with the degree of tremor reset caused by the cerebellar stimulation.InterpretationThe excitability of CTC pathway is decreased in PD. Rest and postural tremors in PD are mediated by different neuronal pathways, and the CTC pathway is involved in the generation or transmission of postural tremor. ANN NEUROL 2010
Differential evolution algorithm with co‐evolution of control parameters and penalty factors for constrained optimization problems
Authors: Fan Qinqin , Yan Xuefeng 
Published: December 2010

ABSTRACTConsidering that it is difficult to set suitable penalty factors for the penalty function method, which is one of the most important ways to solve constrained optimization problems, and that the quality of obtained optimal solution mainly depends on the optimization algorithm's performance and handling constraints capacity, a novel differential evolution algorithm with co‐evolution of control parameters and penalty factors, named as CoE‐DE, is proposed. In CoE‐DE, differential evolution operator is applied for evolving the original individuals, which consist of optimal variables. To improve the performance of CoE‐DE and the handling constraints capacity, Alopex algorithm is used to co‐evolve the symbiotic individuals, which consist of two DE control parameters and the penalty factors. To illustrate the whole performance of CoE‐DE, several algorithms are applied to solve 13 benchmark functions and five constrained engineering problems. The results show that the performance of CoE‐DE is better than SR algorithm and similar to α SIMPILE in 13 benchmark functions, and the satisfactory result is obtained in five constrained engineering problems. Copyright © 2010 Curtin University of Technology and John Wiley & Sons, Ltd.
N‐nitrosodimethylamine adsorption in aqueous phase by activated carbons with different porous and surface structures
Authors: Xiaodong Dai , Guoping Li , Zhiheng Zhang , Linda Zou , Zifeng Yan 
Published: December 2010

ABSTRACTN‐nitrosodimethylamine (NDMA) is a member of the N‐nitrosamines family, which are often found in foods, beers and cigarettes and considered to have carcinogenic, mutagenic and teratogenic properties. The adsorption of toxic NDMA from aqueous solution in activated carbons with different porous structures and surface properties was investigated. The activated carbons were modified by heating in nitrogen atmosphere. Nitrogen adsorption/desorption, infrared and thermogarvimetric techniques were utilized to characterize porous structures and surface properties. It was observed that equilibrium data followed the Freundlich isotherm, and most NDMA preferentially adsorbed in approximately 0.45‐nm micropores by physisorption mechanism. The adsorption capacities of thermally treated samples were significantly higher, despite the decreases in micropore volume and surface area. Without thermal treatment, water molecules are preferentially adsorbed in micropores, resulting in lower NDMA adsorption capacity, whereas after treatment, improved hydrophobic pore properties increases NDMA adsorption because of reduced water competition in pores. Thermal treatments would significantly remove surface oxygen groups and carbon atoms, and change the morphology of pore walls, thus altering adsorption behavior. With enhanced surface properties, NDMA was possibly adsorbed with stronger dispersive interaction between the hydrophobic CH3 and the aromatic rings of the carbon surface enabling higher adsorptive capacity. Copyright © 2010 Curtin University of Technology and John Wiley & Sons, Ltd.
ChemInform Abstract: Single Crystal Studies on Boron‐Rich τ‐Borides Ni23‐xMxB6 (M: Zn, Ga, In, Sn, Ir) — The Surprising Occurrence of B4‐Tetrahedra as a Normal Case?
Authors: Kotzott Dominik , Ade Martin , Hillebrecht Harald 
Published: December 2010

AbstractSingle crystals of Ni20Ga3B6, Ni20Ga1.6B10.1, Ni21.4Zn1.6B6, Ni20.0Zn2.4B7.75, Ni21.1Sn1.9B6, Ni20.0Sn2.4B7.75, Ni21.4In1.6B6, Ni22.0In1.0B6, Ni22.2In0.8B6, and Ni12.3Ir8.7B10.4 are prepared from the elements between 1200 and 1500 °C.