bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of a stirred multiwell bioreactor for expansion of CD34+ umbilical cord blood cells in hypoxic conditions
Authors: Luni Camilla , Zagallo Monica , Albania Lara , Piccoli Martina , Pozzobon Michela , De Coppi Paolo , Elvassore Nicola 
Published: March 2011

AbstractBesides having a metabolic role, oxygen is recognized as an important signaling stimulus for stem cells. In hematopoiesis, hypoxia seems to favor stem cell self‐renewal. In fact, long‐term repopulating hematopoietic stem cells reside in bone marrow at concentrations as low as 1% oxygen. However, O2 concentration is difficult to control in vitro. Thermodynamically, we found significant differences between O2 solubility in different media, and in presence of serum. Furthermore, we verified that medium equilibration with a hypoxic atmosphere requires several hours. Thus, in a static culture, the effective O2 concentration in the cell immediate microenvironment is difficult to control and subject to concentration gradients. Stirred systems improve homogeneity within the culture volume. In this work, we developed a stirred bioreactor to investigate hypoxia effect on the expression of stem cell markers in CD34+ cells from umbilical cord blood. The stirring system was designed on top of a standard six‐well plate to favor continuity with conventional static conditions and transfer of culture protocols. The bioreactor volume (10 mL/well) is suitable for cell expansion and multiparametric flow cytometry analyses. First, it was tested at 21% O2 for biocompatibility and other possible effects on the cells compared to static conditions. Then, it was used to study c‐kit expression of CD34+ cells at 5% O2, using 21%‐O2 cultures as a control. In hypoxia we found that CD34+ cells maintained a higher expression of c‐kit. Further investigation is needed to explore the dynamics of interaction between oxygen‐ and c‐kit‐dependent pathways at the molecular level. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Bullying and (re)offending: Results from three samples in the Netherlands
Authors: Bijleveld Catrien , Van der Geest Victor , Hendriks Jan 
Published: March 2011

AbstractAim To investigate the relationship between bullying and (re)offending.Method Carrying out bivariate analyses and multivariate analyses (controlling for Attention Deficit Hyperactivity Disorder (ADHD), parental abuse and neglect and impulsivity) on three large high‐risk groups (male and female juveniles with serious behaviour problems and a group of juvenile sex offenders).Results Only the relationship between bullying victimisation and re‐offending in juvenile sex offenders is significant.Conclusions Addressing bullying as a risk factor for re‐offending seems important in treatment of juvenile sex offenders. Copyright © 2011 John Wiley & Sons, Ltd.
Fenestration of a Gore Helex Septal Occluder device in a patient with diastolic dysfunction of the left ventricle
Authors: Kenny Damien , Cao Qi‐Ling , Hijazi Ziyad M. 
Published: March 2011

AbstractWe report successful deployment of a fenestrated Helex Septal Occluder in a 46‐year‐old lady with a moderate‐sized secundum atrial septal defect and elevated left‐ventricular end diastolic pressure secondary to renovascular hypertension. Initial balloon occlusion of the defect lead to significant rise in left atrial pressure. Creation of a 4‐mm fenestration offered controlled decompression of the left atrium while reducing the atrial shunt considerably. © 2011 Wiley‐Liss, Inc.
The Missing Link: Triplet Fluorocarbonyl Nitrene FC(O)N
Authors: Zeng Xiaoqing , Beckers Helmut , Willner Helge , Grote Dirk , Sander Wolfram 
Published: March 2011

AbstractThe elusive triplet fluorocarbonyl nitrene, FC(O)N (X3A′′), has been generated in high yield from matrix‐isolated FC(O)N3 by ArF excimer laser photolysis (λ=193 nm). As a side product FNCO was formed. The novel nitrene was characterized by IR, UV/Vis, EPR spectroscopy, and quantum‐chemical calculations. All six fundamental vibrations of FC(O)N at 1681.3, 1193.8, 879.8, 646.5, 588.7, and 434.8 cm−1 (argon matrix, 16 K), their 12/13C, 16/18O, and 14/15N isotopic shifts, and four electronic transitions at T0=13 890, 25 428, 29 166, and 30 900 cm−1 that exhibit vibrational fine structures have been detected. Under visible‐light irradiation at λ≥495 nm, FC(O)N reacted with molecular N2 in the matrix cage at 6 K to give back FC(O)N3, whereas near‐UV irradiation at λ≥335 nm yielded FNCO. The singlet–triplet energy gaps of different carbonyl nitrenes are discussed.
ChemInform Abstract: Crystal Chemistry and Stability of “Li7La3Zr2O12” Garnet: A Fast Lithium‐Ion Conductor.
Authors: Geiger Charles A. , Alekseev Evgeny , Lazic Biljana , Fisch Martin , Armbruster Thomas , Langner Ramona , Fechtelkord Michael , Kim Namjun , Pettke Thomas , Weppner Werner 
Published: March 2011

AbstractSingle crystals of the title compound are prepared by sintering mixtures of ZrO2, La2O3, and Li2CO3 using ceramic crucibles in initial steps and later sealed Pt capsules.
ChemInform Abstract: Magnetic Properties of the 1/1 Approximant Ag42In42Gd16 to the Icosahedral Quasicrystal Ag—In—Gd.
Authors: Wang P. , Stadnik Z. M. , Przewoznik J. 
Published: March 2011

AbstractThe new title approximant is obtained by melting mixtures of the elements and characterized by XRD, magnetic susceptibility measurements, and 155Gd Moessbauer spectroscopy.
ChemInform Abstract: Oxidative Transformation of Thiols to Disulfides Promoted by Activated Carbon—Air System.
Authors: Hayashi Masahiko , Okunaga Ken‐ichi , Nishida Shunsuke , Kawamura Kenjiro , Eda Kazuo 
Published: March 2011

AbstractVarious thiols are converted to disulfides by this operationally simple and environmentally friendly new method.
ChemInform Abstract: Microwave‐Enhanced Suzuki—Miyaura Vinylation of Electron‐Rich Sterically Hindered Substrates Utilizing Potassium Vinyltrifluoroborate.
Authors: Brooker Matthew D. , Cooper Stefan M. Jr. , Hodges Dena R. , Carter Rhiannon R. , Wyatt Justin K. 
Published: March 2011

Abstractortho,ortho′‐Substituted aryl bromides are vinylated in a Pd‐catalyzed Suzuki—Miyaura reaction.
ChemInform Abstract: Fluoride‐Promoted Ligand Exchange in Diaryliodonium Salts.
Authors: Wang Bijia , Cerny Ronald L. , Uppaluri ShriHarsha , Kempinger Jayson J. , DiMagno Stephen G. 
Published: March 2011

AbstractDiaryliodinium salts undergo rapid, fluoride‐promoted aryl ligand exchange reaction in acetonitrile at room temperature.
ChemInform Abstract: Selective Fluorination of Substituted Trichloromethyl Benzenes by HF in Liquid Phase: Preparation of Fluorinated Building Blocks.
Authors: Piou Alexandre , Celerier Stephane , Brunet Sylvette 
Published: March 2011

AbstractSelective trifluoromethylation of the corresponding chlorinated compounds is achieved by successive Cl/F exchange under mild conditions using HF as the fluorinating agent.
ChemInform Abstract: N‐Formylation of Amines Catalyzed by Nanogold under Aerobic Oxidation Conditions with MeOH or Formalin.
Authors: Preedasuriyachai Patcharee , Kitahara Hiroaki , Chavasiri Warinthorn , Sakurai Hidehiro 
Published: March 2011

AbstractFor the title reaction an active and selective catalyst is presented under basic conditions.
ChemInform Abstract: MnCl2·4H2O‐Catalyzed Potential Protocol for the Synthesis of Aryl/Vinyl Sulfides.
Authors: Bandaru Madhav , Sabbavarpu Narayana Murthy , Katla Ramesh , Yadavalli Venkata Durga Nageswar 
Published: March 2011

AbstractAn efficient, moisture‐stable, inexpensive, and nontoxic catalytic system for the cross‐ coupling of aryl/vinyl halides with thiols is presented.
ChemInform Abstract: Catalytic Asymmetric Domino Michael Addition—Alkylation Reaction: Enantioselective Synthesis of Dihydrofurans.
Authors: Rueping Magnus , Parra Alejandro , Uria Uxue , Besselievre Francois , Merino Estibaliz 
Published: March 2011

AbstractA broad spectrum of polysubstituted dihydrofuran skeletons is available with a high functional group tolerance.
ChemInform Abstract: Synthesis, Characterization, and Biological Activities of Novel (Z)‐3‐((E)‐1‐(Alkoxyimino)ethyl)‐5‐arylidene‐4‐hydroxypyrroline‐2‐one Derivatives.
Authors: Zhu Zhao‐Yong , Wang Xian‐Feng , Meng Fan‐Gui , Li Qing‐Bin , Zheng Xiao‐Qian , Qiang Sheng , Yang Chun‐Long 
Published: March 2011

AbstractMost of the compounds (V) (24 examples) exhibit noticeable fungicidal activities against C.orbiculare and moderate activities against R.ceralis.
ChemInform Abstract: A Ligand‐Free, Copper‐Catalyzed Cascade Sequence to Indole‐2‐carboxylic Esters.
Authors: Koenig Stefan G. , Dankwardt John W. , Liu Yanbin , Zhao Hang , Singh Surendra P. 
Published: March 2011

AbstractIt is demonstrated, that the reaction of o‐halobenzaldehydes and amidoacetates offers a ready access to the title compounds without the need of an external ligand.
ChemInform Abstract: The Reaction of [(1‐Azaazulen‐2‐yl)imino]phosphorane with Arylaldehydes: Formation of Bis[(1‐azaazulen‐2‐yl)amino]arylmethanes.
Authors: Fujii Hiroyuki , Nagamatsu Kentaro , Gunji Takahiro , Murafuji Toshihiro , Abe Noritaka 
Published: March 2011

AbstractPhosphorane derivative (I) undergoes a reaction with arylaldehydes (II) via the corresponding azaazulenylimine intermediates to afford the bis[(azaazulenyl)‐amino]arylmethanes (III) in low to moderate yields.
ChemInform Abstract: Syntheses of 1‐Substituted‐3‐aminopyrazoles.
Authors: Ji Nan , Meredith Erik , Liu Donglei , Adams Christopher M. , Artman Gerald D. III , Jendza Keith C. , Ma Fupeng , Mainolfi Nello , Powers James J. , Zhang Chun 
Published: March 2011

Abstract1‐Alkylation of pyrrolopyrazoles is achieved by Chan—Lam coupling with trifluoroborates (II) or methylation with methyl iodide to yield 1‐alkyl‐3‐aminopyrazoles after deprotection.
ChemInform Abstract: Heterocyclizations via POCl3‐Based Multicomponent Reactions: A New Approach to One‐Pot Synthesis of a New Spirosystem, 7‐Methyl‐5‐[4‐(aryl/heteryl)thiazol‐2‐yl]‐5,6‐diazaspiro [2,4]hept‐6‐en‐4‐ones.
Authors: Rao V. Rajeswar , Reddy V. Ravinder 
Published: March 2011

AbstractThe one‐pot approach to the title compounds (IV) proceeds more efficiently than the two‐step procedure.
ChemInform Abstract: Synthesis of Benzopyran[2,3‐b]quinolinone Derivatives.
Authors: Han Guangfan , Cui Bin , Chen Lizhuang , Jin Yan 
Published: March 2011

AbstractA series of novel six‐membered tetracyclic compounds, the title benzopyranoquinolines, is synthesized by reaction of 2‐amino‐3‐cyanobenzopyrans (I) with 5‐substituted 1,3‐cyclohexanedione derivatives.
ChemInform Abstract: Cascade Assembly of N,N′‐Dialkylbarbituric Acids and Aldehydes: A Simple and Efficient One‐Pot Approach to the Substituted 1,5‐Dihydro‐2H,2′H‐spiro(furo [2,3‐d]pyrimidine‐6,5′‐pyrimidine)2,2′,4,4′,6′(1′H,3H,3′H)‐pentone Framework.
Authors: Elinson Michail N. , Vereshchagin Anatolii N. , Stepanov Nikita O. , Belyakov Pavel A. , Nikishin Gennady I. 
Published: March 2011

AbstractReaction of barbituric acid (I) with aromatic aldehydes is investigated in the presence of bromine under 2 different sets of reaction conditions.
ChemInform Abstract: Pyrazolobenzotriazinone Derivatives as COX Inhibitors: Synthesis, Biological Activity, and Molecular‐Modeling Studies.
Authors: Raffa Demetrio , Migliara Onofrio , Maggio Benedetta , Plescia Fabiana , Cascioferro Stella , Cusimano Maria Grazia , Tringali Giuseppe , Cannizzaro Carla , Plescia Fulvio 
Published: March 2011

AbstractNew pyrazolylbenzotriazinone derivatives of type (VII) and (VIII) are prepared and tested as COX inhibitors.
ChemInform Abstract: Ultrasound‐Assisted Synthesis of C‐Glycosides.
Authors: Jarikote Dilip V. , O'Reilly Ciaran , Murphy Paul V. 
Published: March 2011

AbstractUse of ultrasonication allows the stereoselective preparation of allyl‐ and allenyl‐derivatives of a range of C‐glycosides in high yields within a very short time.
ChemInform Abstract: Total Synthesis of (S)‐(‐)‐Stepholidine Using (S)‐tert‐Butanesulfinylimine.
Authors: Cheng Jianjun , Fu Liqiang , Ling Chenyu , Yang Yushe 
Published: March 2011

AbstractThe protoberberine alkaloid stepholidine (VII) is prepared in an overall yield of 18% by using addition of the laterally lithiated nitrile (II) to the enantiopure sulfinimine (I).
ChemInform Abstract: An Asymmetric Route to 2,3‐Epoxy‐syn‐1,4‐cyclohexane Diol Derivatives Using Ring Closing Metathesis (RCM).
Authors: Maity Soumitra , Ghosh Subrata 
Published: March 2011

AbstractThe epoxy derivative (VII) represents the highly functionalized skeleton of natural products, e.g. eutypoxide A or asperpentyn.
ChemInform Abstract: Butyrolactones from the Fungus Aspergillus terreus BCC 4651.
Authors: Haritakun Rachada , Rachtawee Pranee , Chanthaket Rungtiwa , Boonyuen Nattawut , Isaka Masahiko 
Published: March 2011

Abstractisolation, structure elucidation and biological activities of two new butenolides, butyrolactones VI (Ia) and VII (Ib) and six known compounds
ChemInform Abstract: Constituents of Pongamia pinnata Isolated in a Screening for Activity to Overcome Tumor Necrosis Factor‐Related Apoptosis‐Inducing Ligand‐Resistance.
Authors: Minakawa Tomohiro , Toume Kazufumi , Ahmed Firoj , Sadhu Samir Kumar , Ohtsuki Takashi , Arai Midori A. , Ishibashi Masami 
Published: March 2011

Abstractisolation and structural elucidation of the new furanoflavanone ((S)‐I) along with six known flavonoids and activity of the isolated compounds on resistance to TNF‐related apoptosis‐inducing ligand
ChemInform Abstract: A New Long‐Chain Secondary Alkanediol from the Flowers of Argemone mexicana.
Authors: Brahmachari Goutam , Roy Rajiv , Mandal Lalan C. , Ghosh Partha Pratim , Gorai Dilip 
Published: March 2011

AbstractA new compound (I), characterized as hentriacontane‐3,20‐diol, is extracted from the title weed which is an important medicinal plant in India.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Scuteflorin A.
Authors: Tan Fang , Shen Liu‐Lan , Kwak Young‐Shin , Jeong Jin‐Hyun 
Published: March 2011

AbstractElectrophilic alkylation of aldehyde (I) with methylbutenol (II), followed by spontaneous cyclic ether formation provides the A‐ring of the title compound (VI).
ChemInform Abstract: Antiinfluenza Agents from Traditional Chinese Medicine
Authors: Ge Hu , Wang Yi‐Fei , Xu Jun , Gu Qiong , Liu Hai‐Bo , Xiao Pei‐Gen , Zhou Jiaju , Liu Yanhuai , Yang Zirong , Su Hua 
Published: March 2011

AbstractReview: 164 refs.
Combination external beam radiation and brachytherapy boost with androgen deprivation for treatment of intermediate‐risk prostate cancer
Authors: Hurwitz Mark D. , Halabi Susan , Archer Laura , McGinnis Lamar S. , Kuettel Michael R. , DiBiase Steven J. , Small Eric J. 
Published: March 2011

AbstractBACKGROUND:Combined transperineal prostate brachytherapy and external beam radiation therapy (EBRT) is widely used for treatment of prostate cancer. Long‐term efficacy and toxicity results of a multicenter phase 2 trial assessing combination of EBRT and transperineal prostate brachytherapy boost with androgen deprivation therapy (ADT) for intermediate‐risk prostate cancer are presented.METHODS:Intermediate‐risk patients per Memorial Sloan‐Kettering Cancer Center/National Comprehensive Cancer Network criteria received 6 months of ADT, and 45 grays (Gy) EBRT to the prostate and seminal vesicles, followed by transperineal prostate brachytherapy with I125 (100 Gy) or Pd103 (90 Gy). Toxicity was graded using the National Cancer Institute Common Toxicity Criteria version 2 and Radiation Therapy Oncology Group late radiation morbidity scoring systems. Disease‐free survival (DFS) was defined as time from enrollment to progression (biochemical, local, distant, or prostate cancer death). In addition to the protocol definition of biochemical failure (3 consecutive prostate‐specific antigen rises >1.0 ng/mL after 18 months from treatment start), the 1997 American Society for Therapeutic Radiology and Oncology (ASTRO) consensus and Phoenix definitions were also assessed in defining DFS. The Kaplan‐Meier method was used to estimate DFS and overall survival.RESULTS:Sixty‐one of 63 enrolled patients were eligible. Median follow‐up was 73 months. Late grade 2 and 3 toxicity, excluding sexual dysfunction, occurred in 20% and 3% of patients. Six‐year DFS applying the protocol definition, 1997 ASTRO consensus, and Phoenix definitions was 87.1%, 75.1%, and 84.9%. Six deaths occurred; only 1 was attributed to prostate cancer. Six‐year overall survival was 96.1%.CONCLUSIONS:In a cooperative setting, combination of EBRT and transperineal prostate brachytherapy boost plus ADT resulted in excellent DFS with acceptable late toxicity for patients with intermediate‐risk prostate cancer. Cancer 2011;. © 2011 American Cancer Society.
Integration of ER stress and viral nucleotide sensing in DCs: Mounting a response commensurate to the threat?
Authors: Dalod Marc , Pierre Philippe 
Published: March 2011

AbstractIn response to inflammatory stimulation, DCs have a remarkable pattern of differentiation, including the triggering of specific mechanisms to control the immune response. In this issue of the European Journal of Immunology, a study reports that concomitant stimulation of pattern‐recognition receptors by viral‐type nucleic acids and induction of the unfolded protein response by chemicals synergize in DCs to augment type I interferon and pro‐inflammatory cytokine production. Expression of the transcription factor XBP1 was shown to be necessary and sufficient to induce this synergistic effect. These findings confirm the existence of important connections between the unfolding protein response/ER stress pathway and the production of inflammatory cytokines, which have been recently revealed in different models and immune contexts, as discussed in this Commentary.
Stability of a phenol‐enriched olive oil during storage
Authors: Suárez Manuel , Romero Maria‐Paz , Ramo Tomás , Motilva Maria‐José 
Published: March 2011

AbstractThe use of an emulsifier to stabilize the phenolic compounds added in the preparation of an enriched olive oil was evaluated. Two emulsifiers, lecithin and monoglyceride, were studied. The results showed lecithin to be the most convenient, due to the increase in the value of the oxidative stability of the phenol‐enriched oils in relation to the enrichments prepared with monoglycerides. After that, the shelf life of the prepared oils was evaluated during a period of 256 days of storage at 25°C in the dark. Oil quality parameters, total phenolic content, bitterness index and oxidative stability were studied during the storage period. Additionally, the phenolic composition and antioxidant capacity (by using the ORAC assay) were evaluated at the end of the storage. The phenolic enrichment of the oils allowed the shelf life of the oils to be extended compared with the control (virgin olive oil without phenol addition), delaying the appearance of peroxides and improving their oxidative stability. In addition, the higher content of phenolic compounds in the oils at all stages of storage is desirable in order to increase the intake of these beneficial compounds.Practical applications: The preparation of phenol‐enriched olive oils with a higher phenolic content than the commercial virgin olive oils is of special interest to increase the ingestion of these healthy compounds the daily intake of which is limited due to the high caloric value of olive oil. There are two key points in the development of this product: (i) the dispersion and stabilization of the phenol extract in the oil matrix and (ii) the stability of the phenols in the prepared oils to guarantee the phenol concentration during their shelf life. It is important to study the use of emulsifiers to determine if they allow an improvement in the dispersion of the phenolic extract, and their stabilization in the final product. In addition, the emulsifiers could mask the bitter taste of the enriched oils, which is desirable to increase consumer acceptance of the enriched oil.
Association between areca‐stimulated vimentin expression and the progression of head and neck cancers
Authors: Tseng Yu‐Hsin , Chang Kuo‐Wei , Yang Cheng‐Chieh , Liu Chung‐Ji , Kao Shou‐Yen , Liu Tsung‐Yun , Lin Shu‐Chun 
Published: March 2011

AbstractBackgroundAreca nut chewing is a common oral habit of Asians that is closely associated with the high incidence of head and neck carcinoma. The purpose of this study was to investigate the impacts of areca nut chewing on neoplastic process of head and neck carcinoma.MethodsHead and neck carcinoma cells were treated with areca nut extract to perceive the phenotypic impacts. Tumor tissues were analyzed with immunohistochemistry (IHC) to understand the association between areca‐associated molecular changes and clinical variables.ResultsUpon treatment with areca nut extract, carcinoma cells showed the increase of vimentin. The activation of extracellular signal‐regulated kinase (ERK)/cyclooxygenase (COX)‐2/prostaglandin (PGE)‐2 cascade underlay the upregulation. These cells also exhibited the enhancement of migration and invasion. By knocking down COX‐2 and vimentin expression, the increase of cell mobility was reversed. Tumor exhibiting extensive vimentin and/or COX‐2 expression displayed a significantly worse disease‐associated survival than contrast groups.ConclusionAreca‐modulated vimentin expression enhanced the progression of head and neck carcinoma. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Derivation of cardiac output and alveolar ventilation rate based on energy expenditure measurements in healthy males and females
Authors: Brochu Pierre , Brodeur Jules , Krishnan Kannan 
Published: March 2011

ABSTRACTPhysiologically based pharmacokinetic modeling and occupational exposure assessment studies often use minute ventilation rates (VE), alveolar ventilation rates (VA) and cardiac outputs (Q) that are not reflective of the physiological variations encountered during the aggregate daytime activities of individuals from childhood to adulthood. These variations of VE, VA and Q values were determined for healthy normal‐weight individuals aged 5–96 years by using two types of published individual data that were measured in the same subjects (n = 902), namely indirect calorimetry measurements and the disappearance rates of oral doses of deuterium (2H) and heavy‐oxygen (18O) in urine monitored by gas‐isotope‐ratio mass spectrometry. Arteriovenous oxygen content differences (0.051–0.082 ml of O2 consumed ml−1 of blood) and ratios of the physiological dead space to the tidal volume (0.232–0.419) were determined for oxygen consumption rates (0.157–0.806 l min−1) required by minute energy expenditures ranging from 0.76 to 3.91 kcal min−1. Generally higher values for the 2.5th up to the 99th percentile for VE (0.132–0.774 l kg−1 min−1, 4.42–21.69 l m−2 min−1), VA (0.093–0.553 l kg−1 min−1, 3.09–15.53 l m−2 min−1), Q (0.065–0.330 l kg−1 min−1, 2.17 to 9.46 l m−2 min−1) and ventilation–perfusion ratios (1.12–2.16) were found in children and teenagers aged 5–<16.5 years compared with older individuals. The distributions of cardiopulmonary parameters developed in this study should be useful in facilitating a scientifically sound characterization of the inter‐individual differences in the uptake and health risks of lipophilic air pollutants, particularly as they relate to younger children. Copyright © 2011 John Wiley & Sons, Ltd.