bluuebunny/crossref_metadata_2025_split huggingface dataset:
TGF-β Receptor II Loss Promotes Mammary Carcinoma Progression by Th17-Dependent Mechanisms
Authors: Novitskiy Sergey V. , Pickup Michael W. , Gorska Agnieszka E. , Owens Philip , Chytil Anna , Aakre Mary , Wu Huiyun , Shyr Yu , Moses Harold L. 
Published: September 2011

AbstractWe report that interleukin (IL)-17 significantly increases the secretion of CXC chemokine ligand 1 and 5 (CXCL1/5) from mammary carcinoma cells, and that stimulated secretion of CXCL1/5 by IL-17 is down-regulated by TGF-β through the type II TGF-β receptor (TβRII). Carcinoma cells with conditional knockout of TβRII (Tgfbr2KO) have enhanced sensitivity to IL-17a in the stimulation of chemokine secretion. During polyoma middle T (PyMT)–induced tumor progression, levels of Th17-inducing cytokines TGF-β, IL-6, and IL-23 were increased in PyMT/Tgfbr2KO tumors, which was associated with an increased number of Th17 cells. IL-17 increased the suppressive function of myeloid-derived suppressor cells (MDSC) on T cells through the up-regulation of Arg, IDO, and cyclooxygenase-2. Treatment of PyMT/Tgfbr2KO mice with anti-IL-17 Ab decreased carcinoma growth and metastatic burden. Analysis of human breast cancer transcriptome databases demonstrated a strong association between IL-17 gene expression and poor outcome in lymph node-positive, estrogen receptor-negative, or luminal B subtypes, suggesting potential therapeutic approaches.Significance: TGF-β signaling is a major tumor suppressor pathway and is therefore difficult to target therapeutically. Understanding the downstream effects of abrogation of TGF-β signaling in tumor cells may identify processes that can be targeted therapeutically. We present data indicating that targeting IL-17 signaling, a pathway that is greatly enhanced by loss of TGF-β signaling, could provide a therapeutic benefit. Analysis of human databases indicated a specific group of patients in whom treatment could be more efficient. Cancer Discovery; 1(5): 430–41. © 2011 AACRThis article is highlighted in the In This Issue feature, p. 367
A Molecularly Annotated Platform of Patient-Derived Xenografts (“Xenopatients”) Identifies HER2 as an Effective Therapeutic Target in Cetuximab-Resistant Colorectal Cancer
Authors: Bertotti Andrea , Migliardi Giorgia , Galimi Francesco , Sassi Francesco , Torti Davide , Isella Claudio , Corà Davide , Di Nicolantonio Federica , Buscarino Michela , Petti Consalvo , Ribero Dario , Russolillo Nadia , Muratore Andrea , Massucco Paolo , Pisacane Alberto , Molinaro Luca , Valtorta Emanuele , Sartore-Bianchi Andrea , Risio Mauro , Capussotti Lorenzo , Gambacorta Marcello , Siena Salvatore , Medico Enzo , Sapino Anna , Marsoni Silvia , Comoglio Paolo M. , Bardelli Alberto , Trusolino Livio 
Published: September 2011

Abstract
Only a fraction of patients with metastatic colorectal cancer receive clinical benefit from therapy with anti-epidermal growth factor receptor (EGFR) antibodies, which calls for the identification of novel biomarkers for better personalized medicine. We produced large xenograft cohorts from 85 patient-derived, genetically characterized metastatic colorectal cancer samples (“xenopatients”) to discover novel determinants of therapeutic response and new oncoprotein targets. Serially passaged tumors retained the morphologic and genomic features of their original counterparts. A validation trial confirmed the robustness of this approach: xenopatients responded to the anti-EGFR antibody cetuximab with rates and extents analogous to those observed in the clinic and could be prospectively stratified as responders or nonresponders on the basis of several predictive biomarkers. Genotype–response correlations indicated HER2 amplification specifically in a subset of cetuximab-resistant, KRAS/NRAS/BRAF/PIK3CA wild-type cases. Importantly, HER2 amplification was also enriched in clinically nonresponsive KRAS wild-type patients. A proof-of-concept, multiarm study in HER2-amplified xenopatients revealed that the combined inhibition of HER2 and EGFR induced overt, long-lasting tumor regression. Our results suggest promising therapeutic opportunities in cetuximab-resistant patients with metastatic colorectal cancer, whose medical treatment in the chemorefractory setting remains an unmet clinical need.
Significance: Direct transfer xenografts of tumor surgical specimens conserve the interindividual diversity and the genetic heterogeneity typical of the tumors of origin, combining the flexibility of preclinical analysis with the informative value of population-based studies. Our suite of patient-derived xenografts from metastatic colorectal carcinomas reliably mimicked disease response in humans, prospectively recapitulated biomarker-based case stratification, and identified HER2 as a predictor of resistance to anti-epidermal growth factor receptor antibodies and of response to combination therapies against HER2 and epidermal growth factor receptor in this tumor setting. Cancer Discovery; 1(6); 508–23. ©2011 AACR.
Read the Commentary on this article by Ciardiello and Normanno, p. 472
This article is highlighted in the In This Issue feature, p. 457
Exercise as migraine prophylaxis: A randomized study using relaxation and topiramate as controls
Authors: Varkey Emma , Cider Åsa , Carlsson Jane , Linde Mattias 
Published: September 2011

Aim: Scientific evidence regarding exercise in migraine prophylaxis is required. Therefore this study aimed to evaluate the effects of exercise in migraine prevention. Methods: In a randomized, controlled trial of adults with migraine, exercising for 40 minutes three times a week was compared to relaxation according to a recorded programme or daily topiramate use, which was slowly increased to the individual’s highest tolerable dose (maximum 200 mg/day). The treatment period lasted for 3 months, and migraine status, quality of life, level of physical activity, and oxygen uptake were evaluated. The primary efficacy variable was the mean reduction of the frequency of migraine attacks during the final month of treatment compared with the baseline. Results: Ninety-one patients were randomized and included in the intention-to-treat analysis. The primary efficacy variable showed a mean reduction of 0.93 (95% confidence interval (CI) 0.31–1.54) attacks in the exercise group, 0.83 (95% CI 0.22–1.45) attacks in the relaxation group, and 0.97 (95% CI 0.36–1.58) attacks in the topiramate group. No significant difference was observed between the groups ( p = 0.95). Conclusion: Exercise may be an option for the prophylactic treatment of migraine in patients who do not benefit from or do not want to take daily medication.
MetaLub – a slab method software for the numerical simulation of mixed lubrication regime in cold strip rolling
Authors: Carretta Y , Boman R , Stephany A , Legrand N , Laugier M , Ponthot J-P 
Published: September 2011

A cold-rolling model taking into account mixed lubrication regime has been developed and included into a simulation software named MetaLub. The main objective is to enhance the performances of rolling mills from a lubrication point of view. It means that lubricant rheology but also roll diameters and roughness, etc. can be optimized to improve stability and efficiency of the rolling tool. The main features of MetaLub are briefly presented in this article. Then, two studies of the influence of rolling speed and negative forward slip are discussed. The obtained numerical results are presented and compared to some experimental data from literature and from ArcelorMittal facilities in order to validate the model and to show its capacity to understand and help to improve industrial rolling conditions.
Heparin and warfarin anticoagulation intensity as predictors of recurrence after deep vein thrombosis or pulmonary embolism: a population-based cohort study
Authors: Heit John A. , Lahr Brian D. , Petterson Tanya M. , Bailey Kent R. , Ashrani Aneel A. , Melton L. Joseph 
Published: September 2011

Abstract
To test recommended anticoagulation measures as predictors of 180-day venous thromboembolism (VTE) recurrence, we identified all Olmsted County, MN residents with incident VTE over the 14-year period of 1984-1997, and followed each case (N = 1166) forward in time for VTE recurrence. We tested the activated partial thromboplastin time (APTT), international normalized ratio (INR), and other measures of heparin and warfarin anticoagulation as predictors of VTE recurrence while controlling for baseline and time-dependent characteristics using Cox proportional hazards modeling. Overall, 1026 (88%) and 989 (85%) patients received heparin and warfarin, respectively, and 85 (8%) developed VTE recurrence. In multivariable analyses, increasing proportions of time on heparin with an APTT ≥ 0.2 anti-Xa U/mL and on warfarin with an INR ≥ 2.0 were associated with significant reductions in VTE recurrence, while the hazard with active cancer was significantly increased. Time from VTE onset to heparin start, duration of overlapping heparin and warfarin, and inferior vena cava (IVC) filter placement were not independent predictors of recurrence. At a heparin dose ≥ 30 000 U/d, the median proportion of time with an APTT ≥ 0.2 anti-Xa U/mL was 92%, suggesting that routine APTT monitoring and heparin dose adjustment may be unnecessary. In summary, lower-intensity heparin and standard-intensity warfarin anticoagulation are effective in preventing VTE recurrence.
Novel Redox Photocatalyst Pt–TiO2 for the Synthesis of 2-Methylquinolines from Nitroarenes
Authors: Selvam Kaliyamoorthy , Swaminathan Meenakshisundaram 
Published: September 2011

Abstract
An eco-friendly and efficient procedure for synthesis of 2-methylquinoline derivatives from nitroarenes has been developed by a simple one-pot reaction on the surface of platinum-loaded TiO2 with neat ethanol under UV irradiation without any harsh reagent according to green chemistry. TiO2 catalysts with various amounts of Pt loadings were prepared by photodeposition using chloroplatinic acid solution and characterized by XRD, BET, AFM, HR-TEM, XPS, and DRS. XRD patterns showed that the crystal structure of Pt–TiO2 still remained as anatase phase. The UV–vis spectra indicated that Pt promoted the absorption of visible light. The XPS measurements reveal that platinum particles are present mainly in metallic form. AFM and HR-TEM analysis revealed the presence of nonspherical shaped platinum nanoparticles of the diameter 3–12 nm. Pt–TiO2 on irradiation induces a combined redox reaction with nitroarene and alcohol and this is followed by condensation–cyclization of aniline and oxidation products to give 2-methylquinolines.
Cesium Carbonate Supported on Alumina for the Michael Addition of Diethyl Malonate to Methyl Acrylates
Authors: Hida Tetsunari , Komura Kenichi , Sugi Yoshihiro 
Published: September 2011

Abstract
The cesium salts supported on γ-Al2O3 were highly active catalysts for the Michael addition of diethyl malonate (1) to methyl acrylate (2) in toluene as solvent. The use of a limited amount of 2 gave diethyl [2-(methoxycarbonyl)ethyl]malonate (3), however the formation of diethyl bis[2-(methoxycarbonyl)ethyl]malonate (4) was enhanced by the increase in amounts of 2. Catalytic activities were easily recovered by the calcination of used catalysts. IR and XRD observations indicate that the active catalytic species are Cs2CO3 on Al2O3. The use of malononitrile enhanced the formation of the diadduct as principal products by addition to methyl acrylate. Other methyl acrylates, such as methyl methacrylate and methyl crotonate, gave low yield of the products.
Ordered Silylation of Layered Silicate RUB-51 with Half-Sodalite Cages
Authors: Asakura Yusuke , Matsuo Yuki , Takahashi Nobuyuki , Kuroda Kazuyuki 
Published: September 2011

Abstract
Layered silicate RUB-51 with half-sodalite cages was silylated with dichlorodimethylsilane and trichloromethylsilane. RUB-51, which possesses two confronting Si–O−/Si–OH groups on the interlayer surface, was reacted with bi/tri-functional silylating agents to induce bidentate silylation. RUB-51 silylated with dichlorodimethylsilane was delaminated through ultrasonication in cyclohexane. Layered octosilicate, which also possesses two confronting Si–O−/Si–OH groups to form a bidentate state, was reacted with the same silylating reagents. The comparison of these silylated products derived from two different layered silicates reveals that the structures of silylated interlayer surfaces are varied by the arrangement of the two Si–O−/Si–OH groups. Silylated RUB-51 possesses zigzag grooves on the layer surfaces which will be useful for silicate-based nanomaterials design.
Cross-coupling of Aryl/Alkenyl Silyl Ethers with Grignard Reagents through Nickel-catalyzed C–O Bond Activation
Authors: Zhao Fei , Yu Da-Gang , Zhu Ru-Yi , Xi Zhenfeng , Shi Zhang-Jie 
Published: September 2011

Abstract
C–O activation and its application have drawn much attention since oxygen-based electrophiles are easily available, less toxic, and more environmentally benign. This letter presents systematically results on the Ni-catalyzed Kumada–Tamao–Corriu coupling based on siloxy arenes/alkenes, which provides a new strategy of silyl protection/C–C bond formation sequence in organic synthesis.
Pd(II)-catalyzed Cross-coupling of C(sp2)–H Bonds and Alkyl–, Aryl–, and Vinyl–Boron Reagents via Pd(II)/Pd(0) Catalysis
Authors: Wasa Masayuki , Chan Kelvin S L , Yu Jin-Quan 
Published: September 2011

Abstract
Pd(II)-catalyzed cross-coupling of ortho-C–H bonds in benzoic acid and phenylacetic acid amides with alkyl–, aryl–, and vinyl–boron reagents have been achieved via Pd(II)/Pd(0) catalysis, demonstrating the unprecedented versatility of C–H activation reactions.
Iridium-catalyzed ortho-C–H Borylation of Aryl Ketones with Bis(pinacolato)diboron
Authors: Itoh Hiroshi , Kikuchi Takao , Ishiyama Tatsuo , Miyaura Norio 
Published: September 2011

Abstract
ortho-Selective C–H borylation of aryl ketones with bis(pinacolato)diboron proceeded at 120 °C in octane in the presence of a catalytic amount of iridium(I) complexes comprising 1/2[Ir(OMe)(cod)]2 and AsPh3.
Palladium-catalyzed Cross-coupling of Aryl Iodides with β-Trimethylsiloxy-α-diazoesters: A Novel Approach toward β-Keto-α-arylesters
Authors: Shu Zhibin , Zhang Ji , Zhang Yan , Wang Jianbo 
Published: September 2011

Abstract
Palladium-catalyzed cross-coupling of β-trimethylsiloxy-α-diazoesters with aryl iodides provides a new approach to β-keto-α-arylesters. It is shown that the β-trimethylsiloxy group can significantly suppress the direct 1,2-hydride shift from palladium carbene.
Iron-catalyzed Chemoselective Cross-coupling of α-Bromocarboxylic Acid Derivatives with Aryl Grignard Reagents
Authors: Jin Masayoshi , Nakamura Masaharu 
Published: September 2011

Abstract
We have developed a simple and effective synthetic method of α-arylcarboxylic acid derivatives based on the iron-catalyzed cross-coupling reaction of α-bromocarboxylic acid derivatives with aryl Grignard reagents. The reaction proceeds smoothly at −78 °C in a chemoselective manner to produce the coupling product in good to excellent yields.
Ruthenium-catalyzed Acylation of Arylpyridines with Acyl Chlorides via ortho-Selective C–H Bond Cleavage
Authors: Kochi Takuya , Tazawa Aoi , Honda Kazuki , Kakiuchi Fumitoshi 
Published: September 2011

Abstract
Ruthenium-catalyzed ortho-selective acylation of arylpyridines with acyl chlorides via C–H bond cleavage is described. Aromatic acyl chlorides as well as α,β-unsaturated acyl chlorides were coupled with arylpyridines to give aromatic ketones in the presence of [RuCl2(PPh3)3] as a catalyst and potassium carbonate as a base.
Synthesis and Properties of Acetylene-bridged N-Confused Porphyrin Dimers
Authors: Toganoh Motoki , Takayama Takumi , Ritesh Nandy , Kimizuka Nobuo , Furuta Hiroyuki 
Published: September 2011

Abstract
Acetylene-bridged N-confused porphyrin (NCP) dimers were synthesized by Stille coupling reactions. Moderate electronic interaction between the NCP chromophores was observed in the inner-3H tautomers while strong interaction was observed in the inner-2H tautomers.
Kinetic Studies of the Ni-catalyzed Cross-coupling of Alkyl Halides and a Tosylate with Butyl Grignard Reagent in the Presence of 1,3-Butadiene
Authors: Iwasaki Takanori , Tsumura Asako , Omori Takehiro , Kuniyasu Hitoshi , Terao Jun , Kambe Nobuaki 
Published: September 2011

Abstract
Kinetic studies of the nickel-catalyzed cross-coupling reaction of alkyl bromides, iodides, and tosylates with butyl Grignard reagents in the presence of butadiene were performed. The reaction rate was first order with respect to the halides and the nickel catalyst. The butyl Grignard reagent, at concentrations of ca. 0.4 M or higher, had little effect on the reaction rate. The relative reactivities and activation parameters were determined for these alkyl halides and a tosylate.
Copper-free Sonogashira Coupling Reaction in Phosphonium Amino Acid Ionic Liquids
Authors: Fukuyama Takahide , Rahman Md Taifur , Maetani Shinji , Ryu Ilhyong 
Published: September 2011

Abstract
Phosphonium amino acid ionic liquids were found to be useful for the copper-free and amine-free Sonogashira coupling reaction. A hydrophobic and lipophobic ionic liquid permitted easy separation of the product from ionic liquid and catalyst, and the recovered ionic liquid containing Pd catalyst could be reused.
Kumada–Tamao–Corriu Coupling of Alkyl Halides Catalyzed by an Iron–Bisphosphine Complex
Authors: Hatakeyama Takuji , Fujiwara Yu-ichi , Okada Yoshihiro , Itoh Takuma , Hashimoto Toru , Kawamura Shintaro , Ogata Kazuki , Takaya Hikaru , Nakamura Masaharu 
Published: September 2011

Abstract
An iron(II) chloride complex possessing a sterically demanding ortho-phenylene-tethered bisphosphine ligand shows a high catalytic activity in the Kumada–Tamao–Corriu coupling of nonactivated alkyl halides with aryl Grignard reagents. Primary, secondary, and tertiary alkyl halides can participate as an electrophilic coupling partner. A radical clock experiment using (iodomethyl)cyclopropane exclusively gives the corresponding ring-opening coupling product, suggesting intermediacy of alkyl radical species.
Triarylamines on [3]Radialene Scaffold: Novel [3]Radialene-based, Multistep, Wide-range Redox Systems with Remarkably Low Oxidation Potentials
Authors: Matsumoto Kouzou , Yamada Nao , Enomoto Tetsuya , Kurata Hiroyuki , Kawase Takeshi , Oda Masaji 
Published: September 2011

Abstract
Hexakis[4-(diarylamino)phenyl][3]radialene derivatives show remarkably low oxidation potentials, suggesting the intramolecular through-space interaction between the facing triarylamine moieties. This through-space interaction is confirmed by the ESR spectrum of the corresponding oxidized species.
Monovalent Nickel Complex Bearing a Bulky N-Heterocyclic Carbene Catalyzes Buchwald–Hartwig Amination of Aryl Halides under Mild Conditions
Authors: Nagao Shinya , Matsumoto Taisuke , Koga Yuji , Matsubara Kouki 
Published: September 2011

Abstract
Monovalent nickel complex bearing a bulky N-heterocyclic carbene (NHC) and triphenylphosphine was synthesized and demonstrated to catalyze the Buchwald–Hartwig amination of aryl halides with diarylamines to form triarylamines under mild conditions.
Iron-catalyzed Oxidative Coupling of Alkylamines with Arenes, Nitroalkanes, and 1,3-Dicarbonyl Compounds
Authors: Shirakawa Eiji , Yoneda Tomoki , Moriya Kohei , Ota Kensuke , Uchiyama Nanase , Nishikawa Ryo , Hayashi Tamio 
Published: September 2011

Abstract
FeCl3 in combination with t-BuOOt-Bu as an oxidant was found to catalyze oxidative coupling of alkylamines with arenes, nitroalkanes, and 1,3-dicarbonyl compounds to give arylmethylamines, β-nitroalkylamines, and 2-(aminomethyl)-1,3-dicarbonyl compounds, respectively.
Synthesis of Phenanthridinones and Phenanthridine Derivatives through Palladium-catalyzed Oxidative C–H Coupling of Benzanilides
Authors: Ishida Naoki , Nakanishi Yuuta , Moriya Taisaku , Murakami Masahiro 
Published: September 2011

Abstract
A palladium-catalyzed oxidative C–H coupling reaction of benzanilides using molecular oxygen as the oxidant furnishes phenanthridinones. The palladium-catalyzed reaction in combination with simple derivatization provides an efficient access to a phenanthridine skeleton starting from readily available benzoic acids and anilines.
Palladium-catalyzed Direct C–H Bond Arylation of Simple Arenes with Aryltrimethylsilanes
Authors: Funaki Kenji , Kawai Hiroshi , Sato Tetsuo , Oi Shuichi 
Published: September 2011

Abstract
Direct C–H bond arylation of arenes with aryltrimethylsilanes catalyzed by PdCl2 in the presence of CuCl2 as an oxidant has been developed. In addition to the role as the oxidant, CuCl2 is found to be necessary for the selective cross-coupling reaction.
Palladium-catalyzed Highly Regioselective C-3 Arylation of Imidazo[1,5-a]pyridine
Authors: Huang Chunhui , Giokaris Alexandros , Gevorgyan Vladimir 
Published: September 2011

Abstract
A direct palladium-catalyzed highly regioselective C-3 arylation of imidazo[1,5-a]pyridine with aryl bromides has been developed. This reaction is quite general with respect to the aryl or hetaryl bromide.
Cross-coupling Reactions of Organoboranes: An Easy Method for C–C Bonding
Authors: Suzuki Akira , Yamamoto Yasunori 
Published: September 2011

Abstract
The palladium-catalyzed cross-coupling reaction between different types of organoboron compounds and various organic halides or triflates in the presence of base provides a powerful and general methodology for the formation of carbon–carbon bonds. The Csp2–B compounds (such as aryl- and 1-alkenylboron derivatives) and Csp3–B compounds (alkylboron compounds) readily cross-couple with organic electrophiles to give coupled products selectively in high yields. Recently, the Csp–B compounds (1-alkynylboron derivatives) have been also observed to react with organic electrophiles to produce expected cross-coupled products. The overview of some of such coupling reactions is discussed here in this article.
A Hexameric Porphyrin Triangle Constructed by Suzuki–Miyaura Cross-coupling Reaction
Authors: Song Jianxin , Anabuki Shoma , Aratani Naoki , Shinokubo Hiroshi , Osuka Atsuhiro 
Published: September 2011

Abstract
A meso-to-β directly linked hexameric porphyrin triangle was synthesized by the Suzuki–Miyaura cross-coupling reaction via either one-pot or a stepwise route. Hexakis-zinc(II) complex of the porphyrin triangle exhibits a split Soret band in the absorption spectrum, reflecting the effective exciton coupling over the whole molecule.
Bis(cyclopentadienyldicarbonyliron) as a Convenient Carbon Monoxide Source in Palladium-catalyzed Carbonylative Coupling of Aryl Iodides with Amines, Alcohols, and Thiols
Authors: Nakaya Ryotaro , Yorimitsu Hideki , Oshima Koichiro 
Published: September 2011

Abstract
Bis(cyclopentadienyldicarbonyliron) ([CpFe(CO)2]2) serves as a carbon monoxide source in carbonylative coupling reactions. Treatment of aryl iodides with primary amines in the presence of DBU and [CpFe(CO)2]2 under palladium catalysis provides the corresponding benzamides in good yields. Similar reactions with phenols and thiols provide the corresponding benzoate esters and thioesters, respectively. A catalytic amount of DMAP as an additive promoted the carbonylative coupling reactions with primary alcohol and secondary amine.
Phosphane-free Suzuki–Miyaura Coupling of Aryl Imidazolesulfonates with Arylboronic Acids and Potassium Aryltrifluoroborates under Aqueous Conditions
Authors: Cívicos José Francisco , Gholinejad Mohammad , Alonso Diego A , Nájera Carmen 
Published: September 2011

Abstract
Aryl imidazole-1-sulfonates are efficiently cross-coupled with arylboronic acids and potassium aryltrifluoroborates using only 0.5 mol % of oxime palladacycles 1 under aqueous conditions at 110 °C. Under these simple phosphane-free reaction conditions a wide array of biaryl derivatives has been prepared in high yields. This methodology allows in situ phenol sulfonation and one-pot Suzuki arylation as well as the employment of microwave irradiation conditions.