bluuebunny/crossref_metadata_2025_split huggingface dataset:
Source Parameter Estimation Using Site-Corrected Source Spectra for the 2019 Ridgecrest Earthquake Sequence in Southern California
Authors: Ahn Byeong Seok , Kang Tae-Seob , Yoo Hyun Jae 
Published: February 2025

ABSTRACT
We estimated source parameters, such as corner frequency (fc), stress drop (Δσ), and seismic moment (M0) for the 2019 Ridgecrest earthquake sequence in southern California. Source spectra used to estimate the source parameters were corrected with the site decay parameter (κ0) along with geometrical spreading and inelastic attenuation. The Ridgecrest dataset consisting of 12,943 events from the 2019 Ridgecrest earthquake sequence, distributed by the Community Stress Drop Validation Study of the Southern California Earthquake Center, offers opportunities to explore self-similarity between events and compare source parameter estimates across multiple studies. Using the dataset, κ-values were measured from a linear slope of the natural logarithm of acceleration Fourier spectrum at high frequencies (6–39 Hz). Consequently, the κ0-values of 46 stations were obtained using two methods based on the distance dependence of κ. The source parameters for 9966 events were estimated using the Snoke method (Snoke, 1987). The measurement of κ revealed an obvious magnitude dependence at most stations, and depth dependence at shallower depths (∼3 km) was observed at 31 stations. By correcting source spectra with κ0, alignment with the Brune model was improved, increasing the accuracy of fc and Δσ. Across 736 selected events with a magnitude range of Mw 2.0–4.9, we found negligible dependence between magnitude and Δσ (with a median value of 12.6 MPa), consistent with event self-similarity. We attribute the observed depth dependence of Δσ to vertically heterogeneous attenuation with depth. Despite uncertainties in the estimation of κ0 and the source parameters, the median of Δσ falls within the range of those of previous studies, but we found stronger evidence of self-similarity (Trugman, 2020; Shearer et al., 2022; Bindi et al., 2023a,b). Collectively, these findings suggest that our method for correcting the spectrum is sound.
Flow Cytometric Immunophenotyping of Mixed Phenotype Acute Leukemia in a Tertiary Care Hospital of Eastern Odisha
Authors: Mishra Dharma Niranjan , Singh Gyanraj , Meher Dali , Jena Rabindra Kumar , Mohanty Dibya Prasana 
Published: February 2025

Background: Acute lymphoblastic leukemia affects both adults and children. Mixed phenotype acute leukemia (MPAL) is a rare subset featuring blasts with multiple lineage-specific antigens. Diagnosis is made via flow cytometric immunophenotyping with specific CD markers. This study aims to correlate MPAL's incidence, hematological findings, clinical profiles, and immunophenotypic features with treatment outcomes and prognostic significance.
Materials and Methods: A total of 750 cases of acute leukemia involving pediatric and adult patients were examined at SCB Medical College and Hospital in Cuttack, Odisha. Based on the WHO 2008 criteria, twenty-nine cases of MPAL were identified using morphological, cytochemical, and immunophenotypic features. The study covered all age groups admitted to the Department of Hematology from September 2011 to April 2021.
Results: Flow cytometric analysis of 750 cases showed B lymphoblastic leukemia as the most common subtype. Of the 29 MPAL cases (3.86%), 15 were B/myeloid, 13 T/myeloid, and one B/T/myeloid. Twenty-three cases received induction chemotherapy, with 12 achieving complete remission. The median survival was 11months, with a 15-month survival rate of 39%. Pediatric patients had a 60% survival rate at 15 months, compared to 30% for adults.
Conclusion: MPAL is a rare acute leukemia diagnosed through flow cytometry. Prognostic factors include age at onset, CD34 negativity, HLA-DR presence, BCR-ABL fusion, and MLL rearrangement, which indicate a poor prognosis. Children tend to have better outcomes and complete remission than adults, with therapies for ALL being more effective than those for acute myeloblastic leukemia.
OCT4 and Nestin Expression in the Microenvironment of Primary Central Nervous System Lymphomas
Authors: Calderón-Garcidueñas Ana Laura , García-Trejo Diana Adixa , Gelista-Herrera Noemi , De Arellano Israel Torres-Ramírez 
Published: February 2025

Background: Angiogenesis is essential for the survival of neoplasms. Our aim was to describe the clinical profile of primary central nervous system lymphoma (PCNSL) patients at our institution and explore the immunohistochemical expression of OCT4 and nestin in the tumor microenvironment especially in relation to angiogenesis.
Materials and Methods: All cases of PCNSL from 2016 to 2022 were retrospectively studied, and clinical and radiological characteristics of the patients were obtained. Descriptive statistics were used.
Results: 26 cases were studied; 24 cases (92.3%) were B-cell lymphomas: 23 diffuse large B-cell, and one Burkitt lymphoma. 7.7 % were of T lineage. 13 women and 13 men, had age ranges between 33-71 years (mean 58.16 years). Three patients (12 %) had immunosuppression. Nestin staining revealed hypertrophic astrocytes forming patches about blood vessels with positive cytoplasmic staining in endothelium and pericytes (5-10% of the intra-tumor arterioles). These findings were seen in both B and T lymphomas. OCT4 nuclear expression was only observed in five large B-cell lymphomas and seemed to have relationship with mitoses/HPF (high power field).
Conclusion: The novel finding of endothelial, pericytes and hypertrophic astrocytes staining with nestin, points to the involvement of stem cells promoting angiogenesis as a result of a dialogue between neoplastic cells and vascular stem cells. OCT4 expression seems to have a relationship with cell proliferation whose clinical significance should be investigated in prospective studies.
Incidence of extended spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from women with urinary tract infections in Jordan
Authors: Groom Rania Al- 
Published: February 2025

Background and Objectives: Urinary tract infections are one of the world's major health problems. In addition, clinical disorders may result from the presence of bacteria or fungi in urine. The aim of this study was to isolate Escherichia coli (E. coli) strains from midstream urine samples, and to determine molecular characterization of encoded Extended Spectrum Beta-Lactamase (ESBL) genes.Materials and Methods: Collected urine samples were streaked on MacConkey, blood and EMB agar plates, then identifying E. coli isolates by using antibiotic susceptibility tests. ESBL production was measured using double disc diffusion. Furthermore, uniplex PCR was performed to identify two ESBL genes (blaCTX and blaTEM).Results: Among 412 isolates, 198 (48.1%) were E. coli strains, followed by Staphylococcus saprophyticus, Klebsiella sp., Serratia sp., Enterococci sp. and Proteus sp. with frequency of 132 (32.0%), 51 (12.4%), 15 (3.6%), 10 (2.4%), and 6 (1.5%) respectively. Female participants who were between the ages of 40 and 49 years old, married, and pregnant were more likely to develop urinary tract infections (UTIs). E. coli species were present in 189 (95.5) of the recurrent UTIs. Regarding antimicrobial susceptibility testing of E. coli isolates, the highest percentage of resistance and susceptible rates were found for nalidixic acid (75.8%) and gentamicin (64.1%) respectively. Among the E. coli isolates, 25 (12.6%) were ESBL-producers. The blaCTX-M gene was genetically confirmed in 20 (10.1%) of the isolates.Conclusion: E. coli is the most common cause of UTI and ESBL production leads to increased resistance to common antibiotics and complicates treatment strategies.
Evaluation of the relatedness between the biofilm-associated genes and antimicrobial resistance among Acinetobacter baumannii isolates in the southwest Iran
Authors: Shakib Nafiseh Hosseinzadeh , Hashemizadeh Zahra , Zomorodi Abolfazl Rafati , Khashei Reza , Sadeghi Yeganeh , Bazargani Abdollah 
Published: February 2025

Background and Objectives: Increasing antimicrobial resistance among Acinetobacter baumannii (A. baumannii) strains poses a significant challenge, particularly in intensive care units (ICUs) where these bacteria are common causes of hospital infections. Biofilm production is recognized as a key mechanism contributing to this resistance. This study aims to explore the relationship between biofilm production, the presence of biofilm-associated genes, and antibiotic resistance patterns in A. baumannii isolates obtained from ICU patients.Materials and Methods: We collected 100 A. baumannii isolates from ICU patients at Nemazee Hospital in Shiraz, Iran. Antimicrobial susceptibility testing (AST) was performed using the Kirby-Bauer disk diffusion method, and biofilm production potential was assessed through the tissue culture plate (TCP) method. Additionally, we investigated eleven biofilm-related genes (ompA, bap, csuE, epsA, blaper-1, bfmS, pgaB, csgA, fimH, ptk, and kpsMII) in all isolates using polymerase chain reaction (PCR). The REP-PCR technique was utilized to analyze the genetic relatedness of the isolates (Fig. 4).Results: All isolates displayed multi-drug resistance, with the highest resistance rates observed against ceftazidime, cefotaxime, and trimethoprim/sulfamethoxazole (100%). Gentamicin and amikacin showed the lowest resistance rates at 70% and 84%, respectively. A total of 98% of the isolates were capable of biofilm production, with 32% categorized as strong biofilm producers. The most frequently detected biofilm-associated genes included csuE (99%), bfmS (98%), ompA (97%), and pgaB (89%).Conclusion: Biofilm production significantly contributes to the prevalence of multi-drug resistant A. baumannii strains. It is essential to implement effective antimicrobial stewardship and develop innovative anti-biofilm strategies to address this global health issue.
Laparoscopic preperitoneal repair of lateral hernia - our experience
Authors: Dasgupta Pinak , Ponnusamy Raju , Pai Ajay , Ravuri Niranjan 
Published: February 2025

Aim: Lateral hernias are quite uncommon as compared to other ventral abdominal hernias. This study aims to show the feasibility and technical details of laparoscopic preperitoneal repair of lateral hernia.
Methods: This was a retrospective study performed from April 2016 to March 2024 involving patients with lateral hernia who underwent laparoscopic preperitoneal repair. The data regarding patient demographics, operative details, outcomes and follow-up were analyzed.
Results: A total of 57 patients who underwent laparoscopic preperitoneal repair for lateral hernia were identified. The mean age was 57.4 years (range 35-74), with a male preponderance in the ratio of 1.28:1 (males-32:females-25) and body mass index of 28.7 kg/m2 (range 22.3-34.8). Most of the hernias were of postsurgical etiology (53, 92.9%), while the remaining were post-traumatic (4, 7.0%). No recurrent hernias were observed. The mean hernia defect width was 6.8 cm (range 3-12). The mean operative time was 178 min (range 145-242). There was no conversion to open. There have been no major complications noted. The mean hospital stay was 2.64 days (range 1-4). No recurrences have been reported in 24 months.
Conclusion: Lateral hernia is a rare entity. Based on our experience, the laparoscopic preperitoneal approach is a safe, feasible and effective choice for lateral hernia repair.
A Letter by M. Putsillo to Baron F. von der Osten-Sacken: the Finding in the Book
Authors: Vorobyeva N. V. 
Published: February 2025

The author of the published letter, Mikhail Putsillo (1845–1889) was a researcher and an owner of entomological and mineralogical collections. He was famous as the first Russian scholar who specialized in Korean studies and a compiler of the Russian-Korean dictionary. The letter, addressed to the diplomat, scientist and politician, Baron Reinhold Friedrich Freiherr von der Osten-Sacken, contains some interesting information concerning the author’s work on the “Index of Cases and Manuscripts Related to Siberia” (1879). The edition was dedicated to the 300th anniversary of the accession of Siberia to Russia. The author also mentions the documents he found in the archive of the Ministry of Foreign Affairs (concerning the Age of Exploration discoveries made by Russian sailors in the second half of the 18th century in North America). The letter is pasted into the book belonged previously to Baron Friedrich Freiherr von der Osten-Sacken and is still stored at the Department of Rare Books of the Altai Regional Universal Scientific Library named after V. Ya. Shishkov.
Analisis keberlanjutan pengembangan kawasan agropolitan (Studi kasus: Kecamatan Sepatan, Kabupaten Tangerang)
Authors: Septiawan Yeriko , Mardiah Andri N.R. 
Published: February 2025

<span id="docs-internal-guid-76ccf3d7-7fff-fe9c-56d5-1bd54884c0d8"><span>Masalah ketimpangan antara desa dan kota mengakibatkan timbulnya alih fungsi lahan pertanian menjadi lahan terbangun pada perkotaan, konsep kawasan agropolitan yang berkelanjutan dapat menjadi solusi masalah kesenjangan tersebut. Penelitian ini bertujuan untuk mengukur status keberlanjutan kawasan agropolitan yang berada pada Kecamatan Sepatan, Kabupaten Tangerang. Metode yang digunakan menggunakan analisis MDS (</span><span>Multidimensional Scaling</span><span>) dan analisis </span><span>leverage</span><span>, dengan menggunakan lima dimensi yaitu ekologi, ekonomi, sosial, infrastruktur serta hukum dan kelembagaan. Hasil penelitian menunjukkan bahwa Kawasan Agropolitan Sepatan, memiliki status kurang berkelanjutan (42,02%), dimana dimensi sosial, ekonomi, dan ekologi masih kurang berkelanjutan. Selain itu, terdapat 14 atribut sensitif yang harus diutamakan untuk meningkatkan status keberlanjutan. Maka, untuk mengatasi ketimpangan wilayah, peningkatan status keberlanjutan Kawasan Agropolitan Sepatan membutuhkan kebijakan yang terencana terutama pada dimensi ekonomi, sosial dan ekologi. Atribut sensitif yang teridentifikasi pada penelitian ini juga dapat menjadi pertimbangan dalam pengembangan kawasan agropolitan di titik baru di Kabupaten Tangerang.</span></span>
Analysis of potential tourism development in perintis reservoir by using environmental approach, Suwawa, Bone Bolango
Authors: Chow David , Maura Audrey , Suman Meliana Putri , Wicaksono Salsabilah Hamidah Putri , Pudianti Anna , Vitasurya Vincentia Reni 
Published: February 2025

<p dir="ltr"><span>Perintis Reservoir has big potential with its amazing view, water coverage, and decent nature. However, the reservoir tends to be temporarily crowded by visitor when there is national event that held by government. Moreover, the majority of visitor is only local people. The objective of this study is to create a recommendation and guideline to enhance the future development of Perintis reservoir, so it can be regularly visited by local people, national tourist, and even international tourist. This study method employed various approaches, such as literature review, quantitative data collection, and observation. The identified problem in observation and data collection were solved by literature review. Research results show that there are some problems need to be solved such as inconvenient thermal conditions because of tropical climate and inadequate shading, unready urban facility, unorganized MSME, lack of walkability for pedestrians, and desolate tourism destinations. The environmental approach was chosen as the main solution because it’s the most suitable. The improvement of sidewalk, people domination rather than vehicle, and adding forest bathing sensation by planting wide-crown tree is needed. The Riparian buffer system and rain garden can help to balance water conservation while increasing the naturalness of the landscape. Cycling and other physical activities have a correlation with walkability and should be emphasized. Social physical activities and MSME’s integration with nutrition in wellness tourism themes can be a Perintis reservoir branding. </span></p>
International Community Development: Edukasi IMS dan HIV/AIDS pada Remaja Santri di Pondok Pesantren, Johor Bahru, Malaysia
Authors: Bilah Aisah Nur Ana , Nadzifah Yasmin , Yamani Laura Navika , Khairunisa Siti Qamariyah , Indriati Dwi Wahyu , Dinana Zayyin , Manas Nor Hasmaliana Abdul , Fuzi Siti Fatimah Zaharah Mohamad , Ya’akob Harisun , Aman Nor Farahiyah , Yusoff Nor Ida Madiha 
Published: February 2025

Community development programs have the potential to enhance adolescents' awareness of the risks associated with sexually transmitted infections (STIs) and the preventive measures that can be taken to mitigate those risks, including HIV/AIDS. The International Community Development program was organized by the Research Centre on Global Emerging and Re-emerging Infectious Diseases (RC-GERID) of Universitas Airlangga. The topic of the program was the prevention of STIs and HIV/AIDS among adolescent boarding school students. The objective of this activity is to enhance the student's knowledge and comprehension of STIs and HIV/AIDS, as well as the measures that can be taken to prevent the transmission of infectious diseases. The participants were 100 Madrasah Tahfidz Al-Quran An-Nur students in Johor Bahru, Malaysia. The methodology employed in this activity comprised pre-test and post-test questionnaires completed by participants, lectures, question-and-answer sessions, and discussions. The results demonstrated a statistically significant increase in knowledge and understanding of STIs, HIV/AIDS, and infection prevention among adolescent students, with an average increase of 22.0% in pre-test and post-test scores. This indicates that the educational material was effectively conveyed to the participants. The activity was conducted in an orderly, conducive, and interactive manner. Further community service with similar activities to be better than now

Abstrak
Remaja merupakan kelompok yang rentan terhadap IMS dengan jumlah terbesar mengidap HIV/AIDS. Program pengabdian masyarakat dapat membantu meningkatkan kesadaran remaja tentang risiko dan langkah pencegahan penyakit IMS dan HIV/AIDS. International Community Development ini diselenggarakan oleh Research Center on Global Emerging and Re-emerging Infectious Diseases (RC-GERID) Universitas Airlangga, dengan topik pencegahan IMS (Infeksi Menular Seksual) dan HIV/AIDS pada remaja santri pondok pesantren. Tujuan kegiatan ini untuk meningkatkan pengetahuan dan pemahaman siswa mengenai IMS dan HIV/AIDS serta langkah pencegahan penyakit infeksi. Peserta kegiatan yaitu remaja santri di Madrasah Tahfidz Al-Quran An-Nur, Johor Bahru, Malaysia yang berjumlah 100 orang. Metode dalam kegiatan ini yaitu pengisian pre-test dan post-test oleh peserta, ceramah, tanya jawab dan diskusi. Hasil menunjukan bahwa adanya peningkatan pengetahuan dan pemahaman tentang IMS, HIV/AIDS, dan pencegahan infeksi pada remaja santri, dengan kenaikan nilai pre-test dan post-test sebesar 22,0%. Hal ini berarti materi edukasi tersampaikan dengan baik kepada peserta. Kegiatan berlangsung dengan tertib, kondusif, dan interaktif. Pengabdian masyarakat selanjutnya dengan kegiatan serupa agar lebih baik dari sekarang.
High-Resolution Fault Geometry and Motion of the August 23, 2011, Mw 5.8 Mineral, Virginia, Aftershock Sequence Revealed Using Double-Difference and Moment-Tensor Inversion Methods
Authors: Hilfiker Stephen G. , Ebel John 
Published: February 2025

Abstract
The August 23 , 2011 MW 5.8 Mineral, Virginia, earthquake, the largest magnitude event recorded in the Central Virginia Seismic Zone, caused widespread damage and generated a lengthy and well-recorded aftershock sequence. Over 1600 aftershocks, recorded using a dense network of seismometers in the 4 months following the mainshock, offer an important opportunity to study the fault structure responsible for the postmainshock seismicity and hence to infer details about the mainshock rupture. In this study, the relative locations of well-recorded aftershocks were calculated to generate a high-resolution model of the fault structures on which the aftershocks took place. Moment-tensor inversions of the P and S amplitudes of dozens of the aftershocks at various locations in the aftershock zone were used to generate focal mechanisms for events on the different fault structures that were imaged by the relative location analysis. These focal mechanisms reveal both normal and thrust faulting on the fault structures. Results from these two analyses map the structures responsible for the aftershock sequence with high spatial resolution. The fault structures responsible for the aftershocks consist of two primary planes, one smaller planar feature, and some off-fault seismicity near the intersection of the two primary planes. The fault planes imaged in this study all appear to be part of the Quail Fault Zone.
Large-scale ice shelf calving events follow prolonged amplifications in flexure
Authors: Bennetts Luke , Teder Nathan , Reid Phillip , Massom Robert , Pitt Jordan , Scambos Ted , Fraser Alexander 
Published: February 2025

Abstract

The retreat of Antarctic ice shelves due to calving and the subsequent reduction in buttressing of the Antarctic Ice Sheet are of major concern for future sea-level rise. Sudden, widespread calving of weakened ice shelves has been linked to fracture amplification forced by ocean swell following regional sea-ice losses. Increases in magnitude and duration of swell-induced ice-shelf flexure in the lead-up to the calving events have not been tracked previously. We present seven-year datasets of sea-ice-barrier lengths and shelf-front flexural stress that encompass large-scale calving events of the Wilkins and Voyeykov ice shelves. We find the ice shelves share traits of preconditioning by prolonged amplifications in flexure and collapse of adjoining fast-ice barriers. We propose a conceptual model for the swell–sea-ice–shelf-front conditions leading to the calving events and discuss its implications further large-scale calving events as sea ice retreats and ice shelves thin.
Investigating the Efficacy of Dexmedetomidine as an Adjuvant to Local Anesthesia in Dentistry: Systematic Review and Meta Analysis
Authors: Abdu Salah Ameen , Asaad Wafa Ali , Wei Tao , Wdaan Muaadh , Wan Wendong , Huang Yu-Qi , Li Ning 
Published: February 2025

Abstract

Background and Objectives: Dexmedetomidine has been considered an effective adjunct to dental local anesthetics. Uncertainty about its efficacy and safety in dental use still remains. This study is primarily designed to evaluate the effectiveness and safety of dexmedetomidine as an adjunct to local anesthesia in dental procedures.
Methods: A meta-analysis of controlled trials assessed the effects of dexmedetomidine as an adjunct to local anesthesia in dental procedures, focusing on anesthesia duration and onset time. Studies were identified via multiple databases, and methodological quality was evaluated using ROBINS-I and Cochrane Risk of Bias tools. RevMan V.5.1 was used for heterogeneity analysis, sensitivity analyses, pooling mean differences (MD) and risk ratios (RR) with 95% confidence intervals (CI), and assessing publication bias.
Results: This meta-analysis included sixteen clinically controlled trials involving 658 patients (n=877 samples). Adding dexmedetomidine significantly reduced onset time by 48.78 seconds (95% CI: -64.22 to -33.35 seconds) and prolonged analgesia duration by 31.10 minutes (95% CI: 13.77 to 48.43 minutes). It also significantly increased postoperative analgesic duration by 186.19 minutes (95% CI: 109.09 to 263.29 minutes). Hemodynamic analysis revealed non-significant changes in heart rate, intraoperative systolic and diastolic pressures, and oxygen saturation. It is important to note that minor heart rate and blood pressure fluctuations did not lead to clinically significant hypotension or bradycardia during dental procedures.
Conclusions:Dexmedetomidine enhances dental local anesthesia by providing quicker onset, longer duration, improved postoperative pain management, and a favorable safety profile, though further research is needed to address variability.