bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental demonstration of an ultrafast all‐optical bit‐error indicating scheme
Authors: Finot C. , Fatome J. 
Published: December 2010

AbstractWe experimentally demonstrate an all‐optical bit error monitoring scheme based on the self‐phase modulation occurring during the propagation in a highly nonlinear fiber followed by an optical bandpass filter. Numerical simulations are confirmed by experimental observations performed at a repetition rate of 40 Gb/s. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:392–395, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25711
Fast electromagnetic simulation algorithm based on hierarchical and curvilinear finite elements
Authors: Ping X. W. , Zhou X. Y. , Yu W. M. , Cui T. J. 
Published: December 2010

AbstractIn this article, hierarchical finite element method (FEM) based on curvilinear elements is used to study three‐dimensional (3D) electromagnetic problems. The incomplete Cholesky preconditioned loose generalized minimal residual solver (LGMRES) based on decomposition algorithm (DA) is applied to solve the FEM equations. The efficiency of the proposed approach is studied on several numerical problems. Numerical results demonstrate that the DA‐based LGMRES is especially effective when the hierarchical FEM is used to solve 3D electromagnetic problems. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:324–331, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25714
CMOS injection‐locked frequency divider with two series‐LC resonators
Authors: Jang Sheng‐Lyang , Shih Chih‐Chieh , Liu Cheng‐Chen , Juang Miin‐Horng 
Published: December 2010

AbstractA fourth order resonator has been implemented to design an injection locked frequency divider (ILFD) implemented in a 0.18‐μm CMOS process. The ILFD is realized with a cross‐coupled nMOS LC‐tank oscillator with a direct injection MOSFET and two series‐LC resonators. At the supply voltage of 0.8 V, the low‐band free‐running tuning frequency is from 2.7 to 3.18 GHz. One excited high‐band frequency band is measured, and the free‐running tuning frequency is from 4.07 to 4.13 GHz. The divide‐by‐2 operational locking range is from 3.4 to 9.4 GHz, and the divide‐by‐4 operational locking range is from 10.5 (15.95) GHz to 13.6 (16.9) GHz for the low‐(high)‐frequency band. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:290–293, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25716
Design of a novel planar ultrawideband antenna with 3.5 and 5.5 GHz dual band‐notched characteristics
Authors: Shan K. , Ruan C. L. , Peng L. 
Published: December 2010

AbstractA novel planar ultrawideband (UWB) antenna with 3.5/5.5 GHz dual band‐notched characteristics is presented. The antenna consists of a radiation patch which has an arc‐shaped edge and a partially modified ground plane with a tapered microstrip feeder line. These designs improve the input impedance bandwidth with the operating band covering the whole UWB frequency range (3.1–10.6 GHz). By etching two nested U‐shaped slots in the radiation patch, band‐rejected filtering properties in the worldwide interoperability for microwave access/wireless local area network bands are achieved. Parametric studies are presented to investigate the effect of the antenna geometrical parameters on its performance. Measured results confirm that the antenna is suitable for UWB applications due to its compact size and high performance. A single band‐notched UWB antenna is also provided for references. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:370–375, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25721
Proximity‐fed broadband rectangular microstrip antennas
Authors: Deshmukh Amit A. , Ray K.P. 
Published: December 2010

AbstractThe broadband proximity‐fed rectangular microstrip antenna (RMSA) is proposed. The proximity‐fed antenna has larger bandwidth (BW) and is simpler in design when compared with L‐probe‐fed RMSA. Further, the BW of proximity‐fed antenna is increased by using multiresonator or slot cut configurations. The proposed antennas give a BW of more than 300 MHz (>30%) with broadside radiation pattern with peak gain of 8.5 dBi. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:294–300, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25723
Modeling and design of milled microwave printed circuit boards
Authors: Djordjević Antonije R. , Olćan Dragan I. , Zajić Alenka G. 
Published: December 2010

AbstractThis article investigates the influence of milling process on properties of printed microwave circuits. Furthermore, design guidelines are proposed for optimizing the milling process by leaving large unmilled copper surfaces on the board without deteriorating circuit performance. The proposed concepts are experimentally verified. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:264–270, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25724
Ehrlichia‐induced hemophagocytic lymphohistiocytosis in two children
Authors: Hanson Derek , Walter Andrew W. , Powell Jonathan 
Published: December 2010

AbstractTwo children presented with a history of fever and rash. Lab values revealed pancytopenia, elevated ferritin, coagulopathy, and elevated triglycerides. Both children quickly developed respiratory distress and hypotension requiring admission to the ICU. Bone marrow biopsies revealed hemophagocytosis. Studies for Ehrlichia returned positive. The patients were started on doxycycline and treated for hemophagocytic lymphohistiocytosis (HLH). Each made a full recovery. In both patients, testing for MUNC and perforin genes were found to have no mutation. These two cases demonstrate the importance of considering Ehrlichiosis as a possible trigger of HLH. Pediatr Blood Cancer 2011;56:661–663. © 2010 Wiley‐Liss, Inc.
Solitary skeletal osteosarcoma recurrence. Findings from the Cooperative Osteosarcoma Study Group
Authors: Franke Markus , Hardes Jendrik , Helmke Knut , Jundt Gernot , Jürgens Heribert , Kempf‐Bielack Beate , Kevric Matthias , Tunn Per‐Ulf , Werner Mathias , Bielack Stefan 
Published: December 2010

AbstractBackgroundSolitary skeletal osteosarcoma (OS) manifestations distant from the site of the primary tumor rarely arise as only sign of disease recurrence.MethodsThis report reviews 38 patients with high‐grade central OS of the limbs or axial skeleton and initial complete surgical remission (CR) who developed first recurrences as solitary osseous lesions distant from the primary tumor. The Cooperative Osteosarcoma Study Group (COSS) database was used to evaluate patient‐, tumor‐, and treatment‐related variables and outcomes.ResultsThirty‐eight patients (27 males and 11 females; 36 limb and 2 axial primaries) developed solitary osseous recurrences a median of 2.1 years (range: 0.5–14.3) from primary diagnosis. Relapses involved axial (24), extremity (10), or craniofacial bones (4). Treatment for recurrence included surgery (28), radiotherapy (10), and chemotherapy (27). After a median follow‐up of 1.9 years (range: 0.1–21.2) from first recurrence for all 38 patients and 5.5 years (0.3–21.2) for 16 survivors (10 in continuous second CR), 2‐ and 5‐year overall and event‐free survival (EFS) probabilities were 55% and 34% and 34% and 27%, respectively. A long interval to recurrence (>1.5 years) predicted for better overall (P < 0.001) and EFS (P = 0.005). For 21 patients achieving a second CR, 2‐ and 5‐year overall and EFS probabilities were 81% and 61% and 52% and 49%, respectively, while only 1/17 others survived beyond 5 years (P < 0.001). Survivors (14/16) had also received second‐line chemotherapy.ConclusionFirst solitary skeletal recurrences of OS should be treated with curative intent. Some presumed bone metastases may represent second primary OSs. Pediatr Blood Cancer 2011;56:771–776. © 2010 Wiley‐Liss, Inc.
Prospective medical assessment of adults surviving childhood cancer: Study design, cohort characteristics, and feasibility of the St. Jude Lifetime Cohort Study
Authors: Hudson Melissa M. , Ness Kirsten K. , Nolan Vikki G. , Armstrong Gregory T. , Green Daniel M. , Morris E. Brannon , Spunt Sheri L. , Metzger Monika L. , Krull Kevin R. , Klosky James L. , Srivastava Deo Kumar , Robison Leslie L. 
Published: December 2010

AbstractBackgroundTo facilitate prospective medical assessment of adults surviving pediatric malignancies and advance knowledge about long‐term childhood cancer survivor health, St. Jude Children's Research Hospital (SJCRH) is establishing a lifetime cohort of survivors.MethodsEligibility criteria for inclusion in the St. Jude Lifetime Cohort (SJLIFE) study include: (1) diagnosis of childhood malignancy treated at SJCRH; (2) survival ≥ 10 years from diagnosis; and (3) current age ≥18 years. Three levels of participation are offered: (1) comprehensive evaluation on SJCRH campus; (2) limited home evaluation; or (3) completion of health surveys only. A systematic recruitment structure based upon blocks of 50 patients initially focused on leukemia and lymphoma survivors and patients eligible for pilot studies.ResultsAs of January 1, 2010, 1,625 (42%) of 3,900 eligible ≥10‐year survivors have been contacted. Among the first 1,000 potentially eligible survivors selected for recruitment, 971 were subsequently confirmed to fulfill eligibility criteria. To date, 898/971 (92.5%) have been successfully contacted of whom 825 (91.8%) have agreed to participate. Among participants, 88.6% agreed to comprehensive medical evaluation, 0.4% limited local evaluation, and 11.0% survey only. Anticipated minimum overall participation rate for medical evaluation is 75.3% (731/971). Comparison of those contacted who agreed versus declined to participate revealed a greater proportion of males who declined participation (P = 0.001).ConclusionsEarly results of the SJLIFE study support its feasibility to recruit aging childhood cancer survivors to research investigations evaluating late health outcomes by medical assessments. Pediatr Blood Cancer 2011;56:825–836. © 2010 Wiley‐Liss, Inc.
Neurocognitive deficits in children with sickle cell disease: a comprehensive profile
Authors: Hijmans Channa T. , Fijnvandraat Karin , Grootenhuis Martha A. , van Geloven Nan , Heijboer Harriët , Peters Marjolein , Oosterlaan Jaap 
Published: December 2010

AbstractBackgroundSickle cell disease (SCD) can lead to profound cerebral damage, associated with neurocognitive deficits. The aim of the current study was to evaluate a broad range of neurocognitive functions in children with SCD compared to a SES‐matched control group, in order to gain more insight into the specific deficits of these patients.MethodsForty‐one children with homozygous SCD (HbSS or HbS‐β0‐thalassemia) and 38 controls were assessed on a comprehensive set of well‐defined and validated measures of neurocognitive functioning. Besides general intelligence, we evaluated executive functioning extensively (including response inhibition, sustained attention, planning, visuo‐spatial working memory, and verbal working memory) as well as visuo‐motor functioning.ResultsSCD was clearly associated with lower IQ scores. More than one in three children with SCD had a Full‐scale IQ below 75. Furthermore, children with SCD showed deficits in visuo‐motor functioning. Some evidence was found for executive dysfunction: Children with SCD displayed poor visuo‐spatial working memory, as well as subtle deficits in sustained attention and planning. No significant differences were found between children with SCD and controls in terms of response inhibition and verbal working memory.ConclusionsChildren with SCD are at increased risk of lower intelligence, visuo‐motor impairments, and executive dysfunction. These neurocognitive deficits may underlie high rates of scholastic impairments in these children. The present findings further illuminate the importance of regular neurocognitive evaluations and future neurocognitive rehabilitation programs for children with SCD. Pediatr Blood Cancer 2011;56:783–788. © 2010 Wiley‐Liss, Inc.
External‐beam radiotherapy for pediatric and young adult desmoid tumors
Authors: Rutenberg Michael S. , Indelicato Daniel J. , Knapik Jacquelyn A. , Lagmay Joanne P. , Morris Christopher , Zlotecki Robert A. , Scarborough Mark T. , Gibbs Charles P. , Marcus Robert B. 
Published: December 2010

AbstractBackgroundTo report long‐term outcomes following radiotherapy for desmoid tumors in children and young adults and identify variables impacting local‐regional control and treatment complications.ProcedureFrom 1978 to 2008, 30 patients <30 years old were treated with radiotherapy for a pathologically confirmed desmoid tumor. The median age at radiotherapy was 23.7 years old (range, 10.3–29.9). Fifteen patients underwent definitive radiotherapy, 14 received radiotherapy after gross total resection, and 1 received preoperative radiotherapy. Sixteen patients received 1.8 Gy once daily and 14 received 1.2 Gy twice daily. Variables analyzed for prognostic value included gender, age at diagnosis, primary or recurrent presentation, age at radiotherapy, tumor site, tumor size, extent of resection, fractionation schedule, and radiotherapy dose.ResultsThe actuarial 15‐year overall survival and local‐regional control rates were 96% and 55%, respectively. Local‐regional control in patients <18 years old at the time of radiotherapy was 20% versus 63% in those 18–30 years old (P = 0.08). Local‐regional control rates for tumors receiving ≥55 Gy and <55 Gy were 79% and 30%, respectively (P = 0.02). No other factors had a statistically significant association with local‐regional control by univariate analysis. Twelve of 30 patients experienced grade 3–4 complications, including pathologic fractures, impaired range of motion, pain, and in‐field skin cancers.ConclusionsThe role of radiotherapy in managing young patients with desmoid tumors remains unclear. Younger patient age is associated with inferior local‐regional control following RT. In children and young adults, doses ≥55 Gy were associated with improved tumor control, but also lead to increased risk of complications. Pediatr Blood Cancer 2011; 57: 435–442. © 2010 Wiley‐Liss, Inc.
Advances in membranous vesicle and exosome proteomics improving biological understanding and biomarker discovery
Authors: Raimondo Francesca , Morosi Lavinia , Chinello Clizia , Magni Fulvio , Pitto Marina 
Published: December 2010

AbstractExosomes are membranous vesicles released by cells in extracellular fluids: they have been found and analyzed in blood, urine, amniotic fluid, breast milk, seminal fluid, saliva and malignant effusions, besides conditioned media from different cell lines. Several recent papers show that exosome proteomes of different origin include both a common set of membrane and cytosolic proteins, and specific subsets of proteins, likely correlated to cell‐type associated functions. This is particularly interesting in relation to their possible involvement in human diseases. The knowledge of exosome proteomics can help not only in understanding their biological roles but also in supplying new biomarkers to be searched for in patients' fluids. This review offers an overview of technical and analytical issues in exosome proteomics, and it highlights the significance of proteomic studies in terms of biological and clinical usefulness.
Quantitative plant proteomics
Authors: Bindschedler Laurence V. , Cramer Rainer 
Published: December 2010

AbstractQuantitation is an inherent requirement in comparative proteomics and there is no exception to this for plant proteomics. Quantitative proteomics has high demands on the experimental workflow, requiring a thorough design and often a complex multi‐step structure. It has to include sufficient numbers of biological and technical replicates and methods that are able to facilitate a quantitative signal read‐out. Quantitative plant proteomics in particular poses many additional challenges but because of the nature of plants it also offers some potential advantages. In general, analysis of plants has been less prominent in proteomics. Low protein concentration, difficulties in protein extraction, genome multiploidy, high Rubisco abundance in green tissue, and an absence of well‐annotated and completed genome sequences are some of the main challenges in plant proteomics. However, the latter is now changing with several genomes emerging for model plants and crops such as potato, tomato, soybean, rice, maize and barley. This review discusses the current status in quantitative plant proteomics (MS‐based and non‐MS‐based) and its challenges and potentials. Both relative and absolute quantitation methods in plant proteomics from DIGE to MS‐based analysis after isotope labeling and label‐free quantitation are described and illustrated by published studies. In particular, we describe plant‐specific quantitative methods such as metabolic labeling methods that can take full advantage of plant metabolism and culture practices, and discuss other potential advantages and challenges that may arise from the unique properties of plants.
Proteogenomics
Authors: Renuse Santosh , Chaerkady Raghothama , Pandey Akhilesh 
Published: December 2010

AbstractThe ability to sequence DNA rapidly, inexpensively and in a high‐throughput fashion provides a unique opportunity to sequence whole genomes of a large number of species. The cataloging of protein‐coding genes from these species, however, remains a non‐trivial task with the majority of initial genome annotation dependent on the use of gene prediction algorithms. Recent advances in mass spectrometry‐based proteomics now enable generation of accurate and comprehensive protein sequence of tissues and organisms. Proteogenomics allows us to harness the wealth of information available at the proteome level and apply it to the available genomic information of organisms. This includes identifying novel genes and splice isoforms, assigning correct start sites and validating predicted exons and genes. It is also possible to use proteogenomics to identify protein variants that could cause diseases, to identify protein biomarkers and to study genome variation. We anticipate proteogenomics to become a powerful approach that will be routinely employed by ‘Genome and Proteome Centers’ of the future.
Recognition and management of abulia in the elderly
Authors: D'Souza Geraldine , Kakoullis Alex , Hegde Nibha , Tadros George 
Published: December 2010

AbstractAbulia is a state of diminished motivation in which an individual may appear apathetic, disinterested, asocial and emotionally remote. There is currently a lack of information on the recognition and management of abulia in elderly patients, despite the fact that it occurs in conjunction with many conditions that are associated with ageing. Here, the authors review the current literature and describe three cases of abulia in elderly patients that responded well to treatment with bromocriptine. Copyright © 2010 Wiley Interface Ltd
Nonradiative surface electromagnetic waves at the interface of uniaxially bianisotropic enantiomeric media
Authors: Tarkhanyan Roland H. , Niarchos Dimitris G. 
Published: December 2010

AbstractA new class of nonradiative surface electromagnetic waves guided by the interface between two enantiomorph uniaxially bianisotropic media is predicted. The waves are caused by bianisotropy and are absent in the case of enantiomorph bi‐isotropic materials. The basic properties of the waves, in particular, dispersion relation and localization conditions differ dramatically from those for conventional surface waves propagating along the interface between chiral and achiral media, as well as between two different achiral media. These waves can be considered as a generalization of Dyakonov‐type surface waves in the case of enantiomeric bianisotropic media.
Determination and comparison of wind loads for industrial reinforced concrete chimneys
Authors: Karaca Zeki , Türkeli̇ Erdem 
Published: December 2010

AbstractLike all other tall structures, determination of wind loads is important for industrial reinforced concrete chimneys. All countries use different wind load standards. These different wind load standards are compared with each other in some studies. For example, in one study by Zhou et al., major international codes and standards for tall buildings were compared.In the first part of this study, modelling information about 10 selected industrial reinforced concrete chimneys is given. All structural and material information about the chimneys are given in the first section. In addition, the first mode natural periods of model chimneys are given. In the second part of this study, procedures of standards used for calculating wind loads are introduced. These standards are ACI 307/98, CICIND 2001, DIN 1056, Eurocode 1 and TS 498. In the third part of the study, the calculated wind loads according to these five standards are shown and compared with each other. In the last part of the study, a conclusion and discussion part is taking place. Copyright © 2010 John Wiley & Sons, Ltd.
Impact of Low‐dose Vasopressin on Trauma Outcome: Prospective Randomized Study
Authors: Cohn Stephen M. , McCarthy Janet , Stewart Ronald M. , Jonas Rachelle B. , Dent Daniel L. , Michalek Joel E. 
Published: December 2010

AbstractBackgroundWe previously found that regardless of the animal injury model used resuscitation strategies that minimize fluid administration requirements lead to better outcomes. We hypothesized that a resuscitation regimen that limited the total volume of fluid administered would reduce morbidity and mortality rates in critically ill trauma patients.MethodsWe performed a double‐blind randomized trial to assess the safety and efficacy of adding vasopressin to resuscitative fluid. Subjects were hypotensive adults who had sustained acute traumatic injury. Subjects were given fluid alone (control group) or fluid plus vasopressin (experimental group), first as a bolus (4 IU) and then as an intravenous infusion of 200 ml/h (vasopressin 2.4 IU/h) for 5 h.ResultsWe randomly assigned 78 patients to the experimental group (n = 38) or the control group (n = 40). The groups were similar in age, sex, preexisting medical illnesses, and mechanism and severity of injury. Serum vasopressin concentrations were higher in the experimental group than in the control group at admission, after infusion of vasopressin (p = 0.01), and 12 h later. The experimental group required a significantly lower total volume of resuscitation fluid over 5 days than did the control group (p = 0.04). The mortality rate at 5 days was 13% in the experimental group and 25% in the control group (p = 0.19). The rates of adverse events, organ dysfunction, and 30‐day mortality were similar.ConclusionsThis is the first trial to investigate the impact of vasopressin administration in trauma patients. Infusion of low‐dose vasopressin maintained elevated serum vasopressin levels and decreased fluid requirements after injury.