bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intraosseous Schwannoma of the Mandible
Authors: Baykul Timuçin , Simsek Hasan Onur , Aksoy Muge Cina , Can Cagri 
Published: June 2012

ABSTRACT
Schwannoma originates from Schwann cells of peripheral nerve sheaths and account for 1% of benign primary bone tumors. The site most commonly involved is the mandible. We present a 47-year-old woman with schwannoma at mandible. Neurosensory examination comprised paresthesia at left side of the mandible. Radiologic examination showed a well-defined unilocular osteolytic lesion which located in the left side of the mandible. The lesion was surgically curetted. The patient is under our follow-up. In this report, clinical and histological features and treatment of the schwannoma are discussed.

How to cite this article
Simsek HO, Aksoy MC, Can C, Baykul T. Intraosseous Schwannoma of the Mandible. Int J Exper Dent Sci 2012;1(1):48-50.
Intraoral Lipoma: A Rare Placement in Mental Foramen Area
Authors: Findik Yavuz , Baykul Timuçin , Kökdere Nesligül Niyaz 
Published: June 2012

ABSTRACTLipomas are the most common benign soft tissue tumors. They are usually surrounded by a thin fibrous capsule and composed of mature fat cells. Approximately 15 to 20% of cases occur in the head and neck region and only 1 to 4% occur in the oral cavity . The most common anatomic site in the oral cavity has frequently been reported as the buccal mucosa, followed by floor of the mouth, tongue and lower lip mucosa. They present as painless, well circumscribed, soft or firm, slow growing submucosal mass. Heredity, fatty tissue degeneration, hormonal imbalance, trauma, infection and chronic irritation have been proposed as etiological agents for lipomas; their etiology remains unknown.How to cite this articleFindik Y, Baykul T, Kökdere NN. Intraoral Lipoma: A Rare Placement in Mental Foramen Area. Int J Exper Dent Sci 2012;1(1):51-53.
Ready for Our Children? Results From a Survey of Upstate New York Hospitals' Utilization of Pediatric Emergency Preparedness Toolkit Guidance
Authors: Clancy Kathleen A. , Kacica Marilyn A. 
Published: June 2012

ABSTRACTObjective: This project evaluated New York (NY) hospitals outside of New York City (upstate) for their awareness and utilization of the NY State Department of Health Pediatric and Obstetric Emergency Preparedness Toolkit (toolkit) and presence of pediatric emergency preparedness planning elements.Methods: A survey assessing toolkit awareness and utilization was distributed to all 145 upstate NY hospitals. Quantitative survey data were analyzed using summary statistics, χ2 analysis, and odds ratios (OR) in aggregate, by hospital size, and by presence of pediatric medicine/surgery, pediatric intensive care unit (PICU), and/or neonatal ICU (NICU) beds (pediatric beds).Results: Of the 145 hospitals, 116 (80%) completed the survey; 86% of these had reviewed the toolkit. Most had staff clinicians with pediatric expertise, but fewer had appointed pediatric clinical (physician or nurse) coordinators. Hospitals with at least one pediatric bed were more than 2.5 times more likely to have an emergency management plan (EMP) for pediatric patients (P =. 0223) and nearly 8 times more likely to have appointed a pediatric physician coordinator (P <. 0001) than were hospitals without pediatric beds. Appointment of a pediatric clinical coordinator was significantly associated (P <. 001) with presence of various pediatric emergency plan elements (OR range: 3.06-15.13), while staff pediatric clinical expertise or toolkit review were not.Conclusions: Appointment of at least one pediatric clinical coordinator and the presence of one or more pediatric beds were significantly associated with having developed key EMP pediatric elements. Further research should examine barriers to pediatric clinical coordinator appointment and explore the awareness that pediatric patients may arrive at nonpediatric hospitals during a disaster with no option for transfer.(Disaster Med Public Health Preparedness. 2012;6:138–145)
Toward the Way Forward: The National Children's Disaster Mental Health Concept of Operations
Authors: Schreiber Merritt , Pfefferbaum Betty , Sayegh Lisa 
Published: June 2012

ABSTRACTAlthough increasing evidence suggests that children are at particular risk from disasters and evidence-based practices have been developed to triage and treat them effectively, no strategy or concept of operations linking best practices for disaster response is currently in place. To our knowledge, this report describes the first effort to address this critical gap and outlines a triage-driven children's disaster mental health incident response strategy for seamless preparedness, response, and recovery elements that can be used now. The national children's disaster mental health concept of operations (NCDMH CONOPS) details the essential elements needed for an interoperable, coordinated response for the mental health needs of children by local communities, counties, regions, and states to better meet the needs of children affected by disasters and terrorism incidents. This CONOPS for children proposes the use of an evidence-based, rapid triage system to provide a common data metric to incident response and recovery action and to rationally align limited resources to those at greater need in a population-based approach.(Disaster Med Public Health Preparedness. 2012;6:174–181)
Community Engagement and Pediatric Disaster Readiness in a Large Urban Disaster Resource Hospital Network: The Case of “The Great California ShakeOut”
Authors: Balasuriya Darshi , Iverson Ellen , Burke Rita V. , Upperman Jeffrey S. 
Published: June 2012

ABSTRACTWe examined the response of 11 Los Angeles County (LAC) hospitals designated as Disaster Resource Centers (DRCs) to a statewide, earthquake preparedness drill, LAC's most comprehensive earthquake disaster drill to date. Semistructured interviews were conducted with the coordinators of 11 of the 14 LAC DRCs within 3 weeks of the drill. Interviews were transcribed and thematic analysis was supported by analytical software (Atlas.ti). Except for one pediatric specialty DRC, most DRCs did little to fully test their institutions' capacity to manage pediatric patients. Few DRCs included children as mock victims. Little or no attention was focused on pediatric triage and other pediatric clinical, psychosocial, and resource issues. Respondents maintained that community readiness is hampered by compartmentalizing the preparedness planning, training, and drilling. Without a mandate to coordinate with other agencies, few DRCs reported coordination with other community entities. Those that did were in smaller submunicipalities within LAC. Community coordination is critical to effective response to disasters, yet disaster preparedness planning and drills are most often uncoordinated and compartmentalized. Drills and training need to be transdisciplinary and coordinated with other community entities likely to play a role in pediatric disaster management.(Disaster Med Public Health Preparedness. 2012;6:182–186)
Using a Geographic Information System (GIS) to Assess Pediatric Surge Potential After an Earthquake
Authors: Curtis Jacqueline W. , Curtis Andrew , Upperman Jeffrey S. 
Published: June 2012

ABSTRACTGeographic information systems (GIS) and geospatial technology (GT) can help hospitals improve plans for postdisaster surge by assessing numbers of potential patients in a catchment area and providing estimates of special needs populations, such as pediatrics. In this study, census-derived variables are computed for blockgroups within a 3-mile radius from Children's Hospital Los Angeles (CHLA) and from Los Angeles County–University of Southern California (LAC–USC) Medical Center. Landslide and liquefaction zones are overlaid on US Census Bureau blockgroups. Units that intersect with the hazard zones are selected for computation of pediatric surge potential in case of an earthquake. In addition, cartographic visualization and cluster analysis are performed on the entire 3-mile study area to identify hot spots of socially vulnerable populations. The results suggest the need for locally specified vulnerability models for pediatric populations. GIS and GT have untapped potential to contribute local specificity to planning for surge potential after a disaster. Although this case focuses on an earthquake hazard, the methodology is appropriate for an all-hazards approach. With the advent of Google Earth, GIS output can now be easily shared with medical personnel for broader application and improvement in planning.(Disaster Med Public Health Preparedness. 2012;6:163–169)
Attachment of Nitroxide Spin Labels to Nucleic Acids for EPR
Authors: Romainczyk Olga , Elduque Xavier , Engels Joachim W. 
Published: June 2012

AbstractIn addition to X‐ray, NMR, and FRET, electron paramagnetic resonance (EPR) can be applied to elucidate the structure of different macromolecular systems and determine local surroundings of paramagnetic centers in DNA and RNA. This technique permits structural characterization as well as dynamic structural changes of macromolecular systems. To do so, free radicals with good stability must be introduced. Here, the site‐directed spin labeling of DNA and RNA based on the Sonogashira cross‐coupling reaction is described. First, the appropriate building blocks, either 5‐iodo‐substituted pyrimidine deoxy‐ or ribo‐nucleoside phosphoramidites are prepared and incorporated by solid‐phase synthesis. Following this, the protected oligonucleotides are “on column” reacted with the acetylenic nitroxide spin labels and subsequently purified. Applications of this technique for duplexes, hairpins, and riboswitches in vitro and in cell are described. Curr. Protoc. Nucleic Acid Chem. 49:7.17.1‐7.17.40. © 2012 by John Wiley & Sons, Inc.
Purification of Synthetic Oligonucleotides via Catching by Polymerization
Authors: Fang Shiyue , Fueangfung Suntara , Yuan Yinan 
Published: June 2012

AbstractThis unit describes the purification of synthetic oligodeoxyribonucleotides (ODN) using a catching‐by‐polymerization approach. In a crude ODN, the major impurity is the failure sequences generated in the coupling step of each synthetic cycle. They are difficult to remove due to the similarity of their physical properties to the full‐length sequences. Two non‐chromatographic methods are described in the unit to solve the problem. In the first one, during automated synthesis, the failure sequences are tagged with a methacrylamide group, which is polymerizable and can participate in acrylamide radical polymerization reactions; the full‐length sequences are not tagged. After synthesis, the crude mixture is subjected to polymerization. The failure sequences are incorporated into an insoluble polymer; the full‐length sequences are extracted with water. In the second method, the full‐length sequences are tagged with a methacrylamide group via a cleavable linker; the failure sequences are not tagged. After synthesis, the full‐length sequences are incorporated into a polymer; the failure sequences are washed away with water. Pure full‐length sequences are cleaved from the polymer. The two methods are complementary. Curr. Protoc. Nucleic Acid Chem. 49:10.14.1‐10.14.21. © 2012 by John Wiley & Sons, Inc.
Gram‐Scale Chemical Synthesis of 2′‐Deoxynucleoside‐5′‐O‐Triphosphates
Authors: Kore Anilkumar R. , Shanmugasundaram Muthian , Senthilvelan Annamalai , Srinivasan Balasubramanian 
Published: June 2012

AbstractA simple, straightforward, reliable, and efficient method for the chemical synthesis of sodium salt of 2′‐deoxynucleoside‐5′‐O‐triphosphates (dNTPs), starting from the corresponding nucleoside, is described. This improved “one‐pot, three‐step” synthetic strategy involves the monophosphorylation of nucleoside, followed by reaction with tributylammonium pyrophosphate and hydrolysis of the resulting cyclic intermediate to provide the corresponding dNTP in good yields (65% to 70%). It is noteworthy that the protocol holds good for both the purine deoxynucleotides, such as 2′‐deoxyguanosine‐5′‐O‐triphosphate (dGTP) and 2′‐deoxyadenosine‐5′‐O‐triphosphate (dATP), and pyrimidine deoxynucleotides, such as 2′‐deoxycytidine‐5′‐O‐triphosphate (dCTP), thymidine‐5′‐O‐triphosphate (TTP), and 2′‐deoxyuridine‐5′‐O‐triphosphate (dUTP). Curr. Protoc. Nucleic Acid Chem. 49:13.10.1‐13.10.12. © 2012 by John Wiley & Sons, Inc.
Using Galaxy to Perform Large‐Scale Interactive Data Analyses
Authors: Hillman‐Jackson Jennifer , Clements Dave , Blankenberg Daniel , Taylor James , Nekrutenko Anton , Team Galaxy 
Published: June 2012

AbstractInnovations in biomedical research technologies continue to provide experimental biologists with novel and increasingly large genomic and high‐throughput data resources to be analyzed. As creating and obtaining data has become easier, the key decision faced by many researchers is a practical one: where and how should an analysis be performed? Datasets are large and analysis tool set‐up and use is riddled with complexities outside of the scope of core research activities. The authors believe that Galaxy provides a powerful solution that simplifies data acquisition and analysis in an intuitive Web application, granting all researchers access to key informatics tools previously only available to computational specialists working in Unix‐based environments. We will demonstrate through a series of biomedically relevant protocols how Galaxy specifically brings together (1) data retrieval from public and private sources, for example, UCSC's Eukaryote and Microbial Genome Browsers, (2) custom tools (wrapped Unix functions, format standardization/conversions, interval operations), and 3rd‐party analysis tools. Curr. Protoc. Bioinform. 38:10.5.1‐10.5.47. © 2012 by John Wiley & Sons, Inc.
Self‐Assembled Nanowires of Organic n‐Type Semiconductor for Nonvolatile Transistor Memory Devices
Authors: Chou Ying‐Hsuan , Lee Wen‐Ya , Chen Wen‐Chang 
Published: June 2012

AbstractOrganic nonvolatile transistor‐type memory (ONVM) devices are developed using self‐assembled nanowires of n‐type semiconductor, N,N′‐bis(2‐phenylethyl)‐perylene‐3,4:9,10‐tetracarboxylic diimide (BPE‐PTCDI). The effects of nanowire dimension and silane surface treatment on the memory characteristics are explored. The diameter of the nanowires is reduced by increasing the non‐solvent methanol composition, which led to the enhanced crystallinity and high field‐effect mobility. The BPE‐PTCDI nanowires with small diameters induce high electrical fields and result in a large memory window (the shifting of the threshold voltage, ΔVth). The ΔVth value of BPE‐PTCDI nanowire based ONVM device on the bare substrate can reach 51 V, which is significantly larger than that of thin film. The memory window is further enhanced to 78 V with the on/off ratio of 2.1 × 104 and the long retention time (104 s), using a hydrophobic surface (such as trichloro(phenyl)silane‐treated surface). The above results demonstrate that the n‐type semiconducting nanowires have potential applications in high performance non‐volatile transistor memory devices.
A Magnetic Particle‐Supported Sulfonic Acid Catalyst: Tuning Catalytic Activity between Homogeneous and Heterogeneous Catalysis
Authors: Koukabi Nadiya , Kolvari Eskandar , Zolfigol Mohammad Ali , Khazaei Ardeshir , Shaghasemi Behzad Shirmardi , Fasahati Behzad 
Published: June 2012

AbstractSurface functionalization of magnetic particles is an elegant way to bridge the gap between heterogeneous and homogeneous catalysis. The introduction of magnetic particles (MPs) in a variety of solid matrices allows the combination of well‐known procedures for catalyst heterogenization with techniques for magnetic separation. We have conveniently loaded sulfonic acid groups on magnetic particles supports in which chlorosulfonic acid is used as sulfonating agent. The main targets are room temperature, solvent‐free conditions, rapid (immediately) and easy immobilization technique, and low cost precursors for the preparation of highly active and stable MPs with high densities of functional groups. The inorganic, magnetic, solid acid catalyst was characterized via Fourier transform infrared spectroscopy (FT‐IR), X‐ray diffraction (XRD), thermal gravimetric analysis (TGA), X‐ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometer (VSM) and titration. The catalyst is active for the Hantzsch reaction and the products are isolated in high to excellent yields (90–98%). Supporting this acid catalyst on magnetic particles offers a simple and non‐energy‐intensive method for recovery and reuse of the catalyst by applying an external magnet. Isolated catalysts were reused for new rounds of reactions without significant loss of their catalytic activity.
Oxidative Aminocarbonylation of Terminal Alkynes for the Synthesis of Alk‐2‐ynamides by Using Palladium‐on‐Carbon as Efficient, Heterogeneous, Phosphine‐Free, and Reusable Catalyst
Authors: Gadge Sandip T. , Khedkar Mayur V. , Lanke Satish R. , Bhanage Bhalchandra M. 
Published: June 2012

AbstractPalladium‐on‐carbon (Pd/C)‐catalyzed oxidative aminocarbonylations of alk‐1‐ynes with secondary amines provide the corresponding alk‐2‐ynamides in a good to excellent yields. This new methodology is applicable for the synthesis of a wide range of biologically active alk‐2‐ynamide derivatives. The developed protocol avoids the use of phosphine ligands, with an additional advantage of palladium catalyst recovery and reuse for up to four consecutive cycles.
Synthesis of Alcohols via a Rhodium‐Catalyzed Hydroformylation– Reduction Sequence using Tertiary Bidentate Amine Ligands
Authors: Cheung Lawrence L. W. , Vasapollo Giuseppe , Alper Howard 
Published: June 2012

AbstractThe synthesis of alcohols from aromatic olefins is described using a rhodium‐catalyzed hydroformylation–reduction sequence with the assistance of a tertiary diamine ligand. The alcohols are produced in excellent branched to linear ratios and in good to excellent isolated yields. In all cases no aldehyde product, from hydroformylation, or alkyl product, from olefin reduction, was detected.
Solution‐Processed TiO2 Nanoparticles as the Window Layer for CuIn(S,Se)2 Devices
Authors: Zhou Huanping , Song Tze‐Bin , Chung Choong‐Heui , Lei Bao , Bob Brion , Zhu Rui , Duan Hsin‐Sheng , Hsu Chia‐Jung , Yang Yang 
Published: June 2012

AbstractAs a wide‐bandgap semiconductor, titanium dioxide (TiO2) with a porous structure has proven useful in dye‐sensitized solar cells, but its application in low‐cost, high‐efficiency inorganic photovoltaic devices based on materials such as Cu(InGa)Se2 or Cu2ZnSnS4 is limited. Here, a thin film made from solution‐processed TiO2 nanocrystals is demonstrated as an alternative to intrinsic zinc oxide (i‐ZnO) as the window layer of CuInSxSe1−x solar cells. The as‐synthesized, well‐dispersed, 6 nm TiO2 nanocrystals are assembled into thin films with controllable thicknesses of 40, 80, and 160 nm. The TiO2 nanocrystal films with thicknesses of 40 and 80 nm exhibit conversion efficiencies (6.2% and 6.33%, respectively) that are comparable to that of a layer of the typical sputtered i‐ZnO (6.42%). The conversion efficiency of the devices with a TiO2 thickness of 160 nm decreases to 2.2%, owing to the large series resistance. A 9‐hour reaction time leads to aggregated nanoparticles with a much‐lower efficiency (2%) than that of the well‐dispersed TiO2 nanoparticles prepared using a 15‐hour reaction time. Under optimized conditions, the champion TiO2 nanocrystal‐film‐based device shows even higher efficiency (9.2%) than a control device employing a typical i‐ZnO film (8.6%).
Myelodysplastic syndromes: 2012 update on diagnosis, risk‐stratification, and management
Authors: Garcia‐Manero Guillermo 
Published: June 2012

AbstractDisease Overview: The myelodysplastic (MDS) are a very heterogeneous group of myeloid disorders characterized by peripheral blood cytopenias and increased risk of transformation to acute myelogenous leukemia (AML). MDS occurs more frequently in older male and in individuals with prior exposure to cytotoxic therapy.Diagnosis: Diagnosis of MDS is based on morphological evidence of dysplasia upon visual examination of a bone marrow aspirate and biopsy. Information obtained from additional studies such as karyotype, flow cytometry or molecular genetics is complementary but not diagnostic.Risk‐stratification: Prognosis of patients with MDS can be calculated using a number of scoring systems. In general, all these scoring systems include analysis of peripheral cytopenias, percentage of blasts in the bone marrow and cytogenetic characteristics. The most commonly used system is the International Prognostic Scoring System. IPSS is likely to be replaced by a new revised score (IPSS‐R) and by the incorporation of new molecular markers recently described.Risk‐adapted therapy: Therapy is selected based on risk, transfusion needs, percent of bone marrow blasts, and, more recently, cytogenetic profile. Goals of therapy are different in lower risk patients than in higher risk. In lower risk, the goal is to decrease transfusion needs and transformation to higher risk disease or AML. In higher risk, the goal is to prolong survival. Current available therapies include growth factor support, lenalidomide, hypomethylating agents, intensive chemotherapy, and allogeneic stem cell transplantation. The use of lenalidomide has significant clinical activity in patients with lower risk disease, anemia and a chromosome 5 alteration. 5‐azacitidine and decitabine have activity in higher risk MDS. 5‐azacitidine has been shown to improve survival in higher risk MDS. A number of new molecular lesions have been described in MDS that may serve as new therapeutic targets or aid in the selection of currently available agents. Additional supportive care measures may include the use of prophylactic antibiotics and iron chelation.Management of progressive or refractory disease: At the present time there are no approved interventions for patients with progressive or refractory disease particularly after hypomethylating based therapy. Options include cytarabine based therapy, transplantation and participation on a clinical trial. Am. J. Hematol. 87:692–701, 2012. © 2012 Wiley Periodicals, Inc.