bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical analysis and literature review of two paediatric cases of anti-IgLON5 antibody-related encephalitis
Authors: Feng Mei , Zhou Zhen , Kang Qingyun , Wang Miao , Tang Jingwen , Wu Liwen 
Published: May 2024

IntroductionAnti-IgLON5 antibody-related encephalitis is a rare autoimmune disorder of the central nervous system, predominantly occurring in middle-aged elderly individuals, with paediatric cases being exceptionally rare. This study aims to enhance the understanding of paediatric anti-IgLON5 antibody-related encephalitis by summarising its clinical and therapeutic characteristics.MethodA retrospective analysis was conducted on two paediatric patients diagnosed with anti-IgLON5 antibody-related encephalitis at Hunan Children’s Hospital from August 2022 to November 2023. This involved reviewing their medical records and follow-up data, in addition to a literature review.ResultsThe study involved two patients, one male and one female, aged between 2.5 and 9.6 years, both presenting with an acute/subacute course of illness. Clinically, both exhibited movement disorders (including dystonia, involuntary movements, and ataxia), cognitive impairments, sleep disturbances, and psychiatric symptoms. Patient 1 experienced epileptic seizures, while Patient 2 exhibited brainstem symptoms and abnormal eye movements. Neither patient showed autonomic dysfunction. Patient 1 had normal cerebrospinal fluid (CSF) and Brain MRI findings, whereas Patient 2 showed moderate leukocytosis and mild protein elevation in the CSF, and Brain MRI revealed symmetrical lesions in the basal ganglia and cerebellum. Oligoclonal bands in the CSF were positive in both cases. Both patients tested negative for HLA-DQB*05:01 and HLA-DRB*10:01. They received both first-line and second-line immunotherapies, with Patient 2 showing a poor response to treatment.DiscussionPaediatric cases of anti-IgLON5 antibody-related encephalitis similarly present sleep disturbances as a core symptom, alongside various forms of movement disorders. Immunotherapy is partially effective. Compared to adult patients, these paediatric cases tend to exhibit more pronounced psychiatric symptoms, a more rapid onset, and more evident inflammatory changes in the CSF. The condition appears to have a limited association with HLA-DQB*05:01 and HLA-DRB*10:01 polymorphisms.
Evaluation of the therapeutic effects of rehabilitation therapy on patients with amyotrophic lateral sclerosis—a meta-analysis
Authors: Cheng Jianghua , Niu Xiaomin , Li Hui , Yang Qiuwei , Du Ketao 
Published: May 2024

ObjectiveTo investigate the effect of rehabilitation therapy on the global function, respiratory function, and quality of life in patients with amyotrophic lateral sclerosis (ALS).MethodsPubMed, Web of Science, and The National Library of Medicine (NLM) were systematically searched and the search period was between the date of database establishment and December 31, 2023. The outcome measures finally analyzed included the ALS functional rating scale/revised (ALSFRS/ALSFRS-R), forced vital capacity percentage predicted (FVC%), fatigue severity scale (FSS), and maximal expiratory pressure (MEP).ResultsA total of 13 randomized controlled trials (RCTs) were included, and 5 outcome measures were pooled and analyzed. A total of 657 patients with ALS were enrolled, with 299 in the experimental group (rehabilitation therapy, such as resistance training, endurance training, aerobic training, respiratory muscle training, and standard rehabilitation therapy) and 358 in the control group (conventional interventions, such as simple joint movements or daily stretching). The ALSFRS scores were better in the experimental group than in the control group at 0–4 months (MD = 3.36, 95% CI: 0.82, 5.91, Z = 2.59, p = 0.009) and at 5–8 months (MD = 5.00, 95% CI: −2.42, 7.58, Z = 3.80, p &lt; 0.001). Moreover, the ALSFRS-R scores of the experimental group was better than that of the control group at 5–8 months (MD = 2.83, 95% CI: 1.21, 4.45, Z = 3.42, p &lt; 0.001) and 9–12 months (MD = 1.87, 95% CI: −0.37, 4.11, Z = 1.63, p = 0.10). It was also found that the MEP value of the experimental group was significantly better than that of the control group after intervention (MD = 18.49, 95% CI: 1.47, 35.50, Z = 2.13, p = 0.03). However, there were no significant differences in FVC% value and FSS scores at 0–5 months and 6–12 months between the two groups.ConclusionRehabilitation therapy is helpful in improving the short-, medium-, and long-term global function score of patients with ALS, with positive effects on respiratory function.
Pediatric neuropathology practice in a low- and middle-income country: capacity building through institutional twinning
Authors: Gilani Ahmed , Mushtaq Naureen , Shakir Muhammad , Altaf Ahmed , Siddiq Zainab , Bouffet Eric , Tabori Uri , Hawkins Cynthia , Minhas Khurram 
Published: May 2024

BackgroundAccurate and precise diagnosis is central to treating central nervous system (CNS) tumors, yet tissue diagnosis is often a neglected focus in low- and middle-income countries (LMICs). Since 2016, the WHO classification of CNS tumors has increasingly incorporated molecular biomarkers into the diagnosis of CNS tumors. While this shift to precision diagnostics promises a high degree of diagnostic accuracy and prognostic precision, it has also resulted in increasing divergence in diagnostic and management practices between LMICs and high-income countries (HICs). Pathologists and laboratory professionals in LMICs lack the proper training and tools to join the molecular diagnostic revolution. We describe the impact of a 7-year long twinning program between Canada and Pakistan on pathology services.MethodsDuring the study period, 141 challenging cases of pediatric CNS tumors initially diagnosed at Aga Khan University Hospital (AKUH), Karachi, were sent to the Hospital for Sick Children in Toronto, Canada (SickKids), for a second opinion. Each case received histologic review and often immunohistochemical staining and relevant molecular testing. A monthly multidisciplinary online tumor board (MDTB) was conducted to discuss the results with pathologists from both institutions in attendance.ResultsDiagnostic discordance was seen in 30 cases. Expert review provided subclassification for 53 cases most notably for diffuse gliomas and medulloblastoma. Poorly differentiated tumors benefited the most from second review, mainly because of the resolving power of specialized immunohistochemical stains, NanoString, and targeted gene panel next-generation sequencing. Collaboration with expert neuropathologists led to validation of over half a dozen immunostains at AKUH facilitating diagnosis of CNS tumors.ConclusionsLMIC-HIC Institutional twinning provides much-needed training and mentorship to pathologists and can help in infrastructure development by adopting and validating new immunohistochemical stains. Persistent unresolved cases indicate that molecular techniques are indispensable in for diagnosis in a minority of cases. The development of affordable alternative molecular techniques may help with these histologically unresolved cases.
Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders
Authors: Lv Zheng , Huang Liyuan , Song Yongfu , Lan Yuejiao , Sun Shizhuo , Wang Yongji , Ding Yinan , Lu Xiaodan 
Published: May 2024

BackgroundInsomnia (IS) and circadian rhythm sleep-wake disorders (CRSWD) are complex disorders with limited and unsatisfactory treatment options that can even cause some side effects. By analyzing blood metabolites to reveal underlying biological processes, studies of sleep and the complex interactions between its influencing factors can be elucidated. Therefore, we hope to bring new hope for the treatment of these diseases through blood metabolites.AimsInvestigating the causal link between blood metabolites and IS and CRSWD.MethodsA genome-wide association study (GWAS) for 486 metabolites was used as the exposure, whereas two different GWAS datasets for sleep disorders were the outcome, and all datasets were obtained from publicly available databases. We employed the standard inverse variance weighting (IVW) method for causal analysis, supported by the MR-Egger method, weighted median (WM) method, and MR-PRESSO method for sensitivity analysis to mitigate the impact of pleiotropy. Genetic correlation between IS, CRSWD, and blood metabolites was explored through linkage disequilibrium analysis (LDSC), while Multivariable MR analysis (MVMR) elucidated whether these metabolites exhibit a direct association with IS and CRSWD. Further, we conducted metabolic pathway analysis to identify the specific metabolites driving these relationships.ResultsEmploying meticulous MVMR analysis, we have identified specific metabolites that independently influence IS, including 2-hydroxypalmitate (OR 2.95, 95%CI 1.05–8.31 P = 0.040), X-11786-Methylcysteine (OR = 0.25, 95%CI 0.08–0.76 P = 0.014), and salicylate (OR 0.89, 95%CI 0.83–0.95 P = 9 × 10–4). In the context of CRSWD, our findings reveal direct associations with metabolites such as carnitine (OR 0.02, 95%CI: 0.00–0.20, P = 0.002), levulinate (OR 0.06, 95%CI: 0.01–0.64, P = 0.020), p-cresol sulfate (OR 0.25, 95% CI: 0.09–0.67, P = 0.006), and X-14208-Phenylalanylserine (OR 0.36, 95% CI: 0.16–0.81, P = 0.014). These discoveries contribute to a nuanced understanding of the distinct metabolic signatures underlying IS and CRSWD.
PENGARUH VARIASI DAYA DAN LAMA WAKTU KONTAK LAMPU ULTRAVIOLET TIPE C PADA LEMARI STERILISASI TERHADAP PENURUNAN JUMLAH KUMAN PADA ALAT MAKAN DI KANTIN OFFICE PT.X
Authors: Irmawartini Irmawartini , Kusmawati Elma Dwi , Djuhriah Nany 
Published: May 2024

The problem of food sanitation hygiene was very important to be addressed, especially in food management facilities such as office canteens. It was found that the number of germs on cutlery in the PT X canteen exceeded the established quality standard, namely 150 colonies/cm2. Attempts to reduce the number of germs on the cutlery of dishes by sterilization using UV-C light. This study aims to determine the variation in power and the length of contact time of ultraviolet lamp type C (UV-C) using a sterilization cabinet against reducing the number of germs on the cutlery at PT.X This type of research is an experiment with a posttest with control design. The cutlery used as a sample was 25 pieces. Data analysis was bivariate statistic analysis. Based on the results, it was known that there was a decrease in the number of germs after UV-C light irradiation was carried out. Irradiation with a power of 15 watts long contact 25 minutes lowers the number of germs 96.89%, Irradiation with a power of 15 watts long contact 30 minutes lowers the number of germs 98.65%, Irradiation with a power of 30 watts long contact 25 minutes lowers the number of germs 99.89%, and Irradiation with a power of 30 watts long contact 30 minutes decreases the number of germs 100%. A decrease in the number of effective germs occurs at a lamp power of 30 watts with a time contact duration of 30 minutes.
Associations between Social Support and Patient-Reported Outcomes in Patients Receiving Hemodialysis
Authors: Erickson Sarah J. , Yabes Jonathan G. , Han Zhuoheng , Roumelioti Maria-Eleni , Rollman Bruce L. , Weisbord Steven D. , Steel Jennifer L. , Unruh Mark L. , Jhamb Manisha 
Published: May 2024

Key Points

Mean baseline levels of perceived social support (Multidimensional Scale of Perceived Social Support) were comparable with other chronically ill populations.Higher Multidimensional Scale of Perceived Social Support scores were correlated with lower levels of fatigue, pain, depressive symptoms, anxiety, better sleep quality, and health-related quality of life (Short Form-12 Mental Component Score).Moderation analyses revealed male sex and non-Hispanic ethnicity resulted in stronger positive associations of perceived social support with Short Form-12 Mental Component Score.

Background
Patients with ESKD experience high symptom burden, which has been associated with a negative effect on their interpersonal relationships. However, there is limited research exploring associations of social support and patient-reported outcomes among patients receiving hemodialysis.

Methods
This study is a secondary, cross-sectional analyses of the sociodemographic and clinical correlates of perceived social support (Multidimensional Scale of Perceived Social Support [MSPSS]) at baseline. The study examined the extent to which perceived social support is associated with pain, depression, fatigue, anxiety, sleep, and health-related quality of life (Short Form-12 [SF-12] Mental Component Score [MCS] and Physical Component Score.

Results
Of the 160 randomized patients, the mean (SD) age was 58±14 years; years on dialysis was 4.1±4.2; 45% were female; 29% Black, 13% American Indian, and 18% Hispanic; 88% had at least high school education; and 27% were married. Mean baseline levels of perceived social support were comparable with other chronically ill populations. At least high school education (P = 0.04) and being married (P = 0.05) were associated with higher total MSPSS scores. Higher MSPSS scores were correlated with lower levels of fatigue (r=0.21, P = 0.008; higher fatigue scores signify lower fatigue), pain (r=−0.17, P = 0.03), depressive symptoms (r=−0.26, P < 0.001), anxiety (r=−0.23, P = 0.004), better sleep quality (r=−0.32, P < 0.001), and SF-12 MCS (r=0.26, P < 0.001). Moderation analyses revealed male sex and non-Hispanic ethnicity resulted in stronger positive associations of perceived social support with SF-12 MCS.

Conclusions
The level of perceived social support observed among patients receiving thrice-weekly hemodialysis in Technology Assisted Stepped Collaborative Care was similar to those observed in other chronic conditions. Because of the associations between perceived social support and patient-reported outcomes, particularly psychosocial and behavioral health outcomes, targeting social support appears to be warranted among patients receiving hemodialysis.

Clinical Trial registration number:
ClinicalTrials.gov NCT03440853.
Relação entre endometriose e infertilidade nas mulheres: uma revisão integrativa
Authors: Duarte Meyling Eng de Almeida , Campos André Luiz Baião , Galindo Layanne Liege Domingos , Barretto Julia Santos de Almeida , Campos Ana Helena Prado Santana , Santos Mariana Sprakel dos , Galindo Renata Feitosa , Lima Yvnna Santos 
Published: May 2024

Introdução: Endometriose é uma doença crônica e inflamatória causada pelo tecido endometrial do tipo glandular e estromal localizados fora da cavidade uterina. Estudos indicam que 6% a 10% das mulheres em idade reprodutiva possuem endometriose. Destas, 35 a 50% queixarão de infertilidade. Objetivo: Identificar quais seriam os fatores que associam a endometriose com o desenvolvimento da infertilidade nestas pacientes. Metodologia: A apuração de dados foi realizada através das bases Biblioteca Virtual em Saúde Brasil (BVS) e Pubmed com os descritores "Endometriose", "Endometriosis", "Infertilidade", "Infertility" no título dos artigos e as operações booleanas AND para os termos convergentes e OR para seus respectivos em inglês. Após aplicação dos critérios de inclusão, restaram 914 dos 4.662 artigos encontrados na BvS, que passaram por uma triagem que visava excluir, pelo título, os artigos que não se adequassem ao tema, restando assim 22 artigos. Resultados\Discussão: Dos 22 artigos analisados integralmente, foram selecionados 8 que atendiam aos critérios de inclusão e eram enriquecedores para o desenvolvimento desta revisão. . Pela análise destes estudos , observou-se a existência de uma relação causal da endometriose com a infertilidade ao se analisar a ocorrência de gravidez após o tratamento e ao se olhar mais a fundo os fatores que levam a endometriose a possivelmente causar a infertilidade Conclusão:Entre os fatores encontrados que se relacionam à patogênese da infertilidade atribuídos à endometriose estão o fator inflamatório devido à diminuição do clearance celular e o déficit das células natural-killers, as diferenças no fluído folicular dessas pacientes e os fatores que influenciam no concepção após a cirurgia de reparação.
Manifestações orais e craniofaciais da Síndrome de Apert: uma revisão da literatura
Authors: Leal Alessandra de Lima Magalhães , Machado Julia Velasco , Cecon Adriana Salete , Silva Isabela de Cerqueira , Mattos Gabriel Pereira da Silva , Souza Fabio Ribeiro de , Moura Marjhory Fernandes de , Carvalho Vitoria Santos , Oliveira Taís Santos de , Lima Matheus Peres de , Brito Lucas Melchior , Virginio Lucas Dantas , Vechiato Lucas Pereira , Araújo Elisangela Speridiao de , Lucena Pedro Gabriel Azevedo 
Published: May 2024

A síndrome de Apert apresenta desafios craniofaciais complexos, exigindo procedimentos cirúrgicos como correção de cranioestenose e avanço da região médiofacial. Embora menos prevalentes do que em outras síndromes, questões como hidrocefalia e herniação tonsilar ainda são relevantes. Anomalias craniofaciais características, como hipoplasia orbital, mandibular e dental, juntamente com atrasos no desenvolvimento dentário, são comuns. Foi realizada uma revisão sistemática de artigos com sistematização PRISMA no período de 2021 a 2024. usando como base o Pubmed, critérios de inclusão inglês, português e espanhol com descritor “Oral, Craniofacial Apert Syndrome”. Os estudos demonstram que a intervenção ortodôntica e maxilofacial é crucial na prevenção e tratamento dessas condições. Um diagnóstico preciso e um plano de tratamento personalizado são essenciais, destacando a importância de uma equipe odontológica bem treinada na melhoria da saúde bucal e qualidade de vida dos pacientes com síndrome de Apert.
Thermosensitive Polyhedral Oligomeric Silsesquioxane Hybrid Hydrogel Enhances the Antibacterial Efficiency of Erythromycin in Bacterial Keratitis
Authors: Zheng Lan , Chen Ying , Han Yi , Lin Jingwei , Fan Kai , Wang Mengyuan , Teng Ting , Yang Xiuqin , Ke Lingjie , Li Muyuan , Guo Shujia , Li Zibiao , Wu Yunlong , Li Cheng 
Published: May 2024

Bacterial keratitis is a serious ocular infection that can impair vision or even cause blindness. The clinical use of antibiotics is limited due to their low bioavailability and drug resistance. Hence, there is a need to develop a novel drug delivery system for this infectious disease. In this study, erythromycin (EM) was encapsulated into a bifunctional polyhedral oligomeric silsesquioxane (BPOSS) with the backbone of the poly-PEG/PPG urethane (BPEP) hydrogel with the aim of improving the drug efficiency in treating bacterial keratitis. A comprehensive characterization of the BPEP hydrogel was performed, and its biocompatibility was assessed. Furthermore, we carried out the evaluation of the antimicrobial effect of the BPEP-EM hydrogel in
S. aureus
keratitis using in vivo mouse model. The BPEP hydrogel exhibited self-assembling and thermogelling properties, which assisted the drug loading of drug EM and improved its water solubility. Furthermore, the BPEP hydrogel could effectively bind with mucin on the ocular surface, thereby markedly prolonging the ocular residence time of EM. In vivo testing confirmed that the BPEP-EM hydrogel exerted a potent therapeutic action in the mouse model of bacterial keratitis. In addition, the hydrogel also exhibited an excellent biocompatibility. Our findings demonstrate that the BPEP-EM hydrogel showed a superior therapeutic effect in bacterial keratitis and demonstrated its potential as an ophthalmic formulation.
صياغة معادلات رياضية لتحديد البرم والتماثل (J  ) لمستويات الطاقة للنظير 54 Xe 132
Authors: رملة داود العلوي  , د.زياد محمد عبود  
Published: May 2024

ﺘم ﺤﺴﺎب ﻗﻴم ﻟوﻏﺎرﻴﺘم ﻋﻤر اﻟﻨﺼف اﻟﻤﻘﺎرن log(f t ) ﻟﻤﺴﺘوﻴﺎت اﻟطﺎﻗﺔ ﻟﻠﻨظﻴر

Xe 132 اﻟﻨﺎﺘﺠﺔ ﻤن اﻨﺤﻼﻝ اﻟﻤﺴﺘوﻴﻴن ) + (2.3h(4) ﻟﻠﻨظﻴر I 132 و (6.47d(2 - )) ﻟﻠﻨظﻴر

Cs 132 واﻟﻤﺄﺨذﻴن ﻤن اﻟد ارﺴﺔ [5] وﺘﺤدﻴد ﻗﻴم اﻟﺒرم (J) واﻟﺘﻤﺎﺜﻝ (  ) ﻟﻠﻤﺴﺘوﻴﺎت اﻟﺘﻲ

ﺘﻐذي ﺒﺎﻨﺘﻘﺎﻻت ﺒﻴﺘﺎ ) +  , - (  ﺒﺎﺴﺘﺨدام ﻤﻌﺎدﻻت رﻴﺎﻀﻴﺔ ﺘم ﺼﻴﺎﻏﺘﻬﺎ ﺒﺎﺴﺘﺨدام ﺒرﻨﺎﻤﺞ

اﺤﺼﺎﺌﻲ.
Karakteristik Lingkungan Pemukiman Kumuh di Sayolo 3 Kampung Tanjung Kabupaten Sorong Selatan
Authors: Lestari Uun , Shyiang Sri Putri Meira 
Published: May 2024

Distrik Teminabuan merupakan distrik di Kabupaten Sorong Selatan dengan penduduk terbanyak baik berasal dari penduduk asli maupun bagi pendatang. Distrik ini memiliki masyarakat dengan pendidikan rendah, berpenghasilan kurang serta tidak memiliki keterampilan. Terbatasnya keuangan masyarakat dan kebiasaan transit ini menyebabkan kampung tersebut semakin bertambah kumuh. Selain itu disfungsi lahan menghasilkan permukiman kumuh yang akan berefek pada kualitas dan kuantitas berbagai hal, yang berkaitan dengan keadaan sarana, prasarana serta keadaan bangunan di wilayah permukiman kumuh tersebut. Memikirkan pentingnya kondisi tersebut, akhirnya patut dilakukan identifikasi berkaitan karakteristik permukiman kumuh di daerah Sayolo 3 Kampung Tanjung dalam menghadapi masalah-masalah yang terdapat di Sayolo 3 kampung Tanjung dengan tujuan untuk mengkaji secara menyeluruh berbagai keadaan serta karakteristik secara terperinci yang dimiliki permukiman kemudian diperoleh arahan yang cermat maupun efektif. Penelitian ini adalah penelitian dekriptif serta pemilihan lokasi berdasarkan pada pertimbangan bahwa wilayah tersebut memerlukan perhatian dan bantuan serta kebijakan dari pemerintah setempat agar mereka dapat hidup dengan layak. Hasil penelitian ini berupa fisik bangunan, sarana prasarana, status lahan, ekonomi serta sosial budaya masih sangat rendah sehingga masih dibutuhkannya bantuan yang berasal dari pemerintah. Oleh karena itu, Sayolo 3 Kampung Tanjung membutuhkan penanganan serta pengendalian baik dengan komprehensif maupun berkesinambungan.
Teminabuan District is a district in South Sorong Regency with the largest population both from native residents and immigrants. This district has people with low education, low income and no skills. Limited public finances and transit habits have caused the village to become increasingly slum. Apart from that, land dysfunction produces slum settlements which will have an effect on the quality and quantity of various things, related to the condition of facilities, infrastructure and the condition of buildings in the slum settlement area. Considering the importance of these conditions, it is finally appropriate to identify the characteristics of slum settlements in the Sayolo 3 Kampung Tanjung area in dealing with the problems found in Sayolo 3 Kampung Tanjung with the aim of thoroughly examining the various conditions and detailed characteristics of the settlements and then obtaining appropriate directions. careful and effective. This research is descriptive research and the location selection is based on the consideration that the area requires attention, assistance as well as policies from the local government so that they can live properly. The results of this research in the form of physical buildings, infrastructure, land status, economic and social culture are still very low so that assistance from the government is still needed. Therefore, Sayolo 3 Kampung Tanjung requires handling and control both comprehensively and continuously.
Het verkleinen van de kans op dementie door een gezonde leefstijl: van epidemiologisch onderzoek naar public health initiatieven
Authors: Heger Irene 
Published: May 2024

Psychologe Irene Heger deed tijdens haar promotietraject bij het Alzheimer Centrum Limburg onderzoek naar de relatie tussen de leefstijlscore LIBRA, bestaande uit 12 beïnvloedbare risico- en beschermende factoren, en cognitief functioneren. Ook onderzocht zij het kennisniveau van mensen uit de samenleving over de relatie tussen leefstijl en dementie risico en organiseerde zij verschillende public health initiatieven.