bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fasting Indicators of Insulin Sensitivity: Effects of Ethnicity and Pubertal Status
Authors: Adam Tanja C. , Hasson Rebecca E. , Lane Christianne J. , Davis Jaimie N. , Weigensberg Marc J. , Spruijt-Metz Donna , Goran Michael I. 
Published: March 2011

OBJECTIVE
To examine the relationship of fasting indicators of insulin sensitivity with a more invasive measure of insulin sensitivity (frequently sampled intravenous glucose tolerance test [FSIVGTT]) and the effect of Tanner stage and ethnicity on that relationship.

RESEARCH DESIGN AND METHODS
Data were analyzed from 149 overweight girls (97 Hispanic and 52 African American) who were either in the early stages of maturation defined by Tanner stages 1 or 2 (52 Hispanic and 18 African American) or in the later stages of maturation defined by Tanner stages 4 and 5 (45 Hispanic and 34 African American). Fasting indicators of insulin sensitivity (IS) included fasting insulin and glucose and the homeostasis model assessment of insulin resistance (HOMA-IR). IS was derived from an FSIVGTT with minimal modeling.

RESULTS
In Tanner stages 1 and 2, all fasting indicators were significantly associated with IS: (fasting insulin: r = −0.67, P &lt; 0.01; HOMA: r = −0.66, P &lt; 0.01) with no significant influence of ethnicity on these relationships. In Tanner stages 4 and 5, however, all fasting indicators were associated with IS in African American girls (fasting insulin: r = −0.55, P &lt; 0.01; HOMA: r = −0.47, P &lt; 0.01), but none of the indicators were significantly associated with IS in Hispanic girls.

CONCLUSIONS
Fasting indicators were reflective of IS for girls in Tanner stages 1 and 2, regardless of ethnicity and may provide a clinical measure of future risk for type 2 diabetes. In the latter stages of maturation, however, more invasive measures are warranted to adequately determine IS in clinical practice.
Investigation of the Microscopic Viscoelastic Property for Cross-linked Polymer Network by Molecular Dynamics Simulation
Authors: Masumoto Y. , Iida Y. 
Published: March 2011

Abstract
The purpose of this work is to develop a new analytical method for simulating the microscopic mechanical property of the cross-linked polymer system using the coarse-grained molecular dynamics simulation. This new analytical method will be utilized for the molecular designing of the tire rubber compound to improve the tire performances such as rolling resistance and wet traction. First, we evaluate the microscopic dynamic viscoelastic properties of the cross-linked polymer using coarse-grained molecular dynamics simulation. This simulation has been conducted by the coarse-grained molecular dynamics program in the OCTA) (http://octa.jp/). To simplify the problem, we employ the bead-spring model, in which a sequence of beads connected by springs denotes a polymer chain. The linear polymer chains that are cross-linked by the cross-linking agents express the three-dimensional cross-linked polymer network. In order to obtain the microscopic dynamic viscoelastic properties, oscillatory deformation is applied to the simulation cell. By applying the time-temperature reduction law to this simulation result, we can evaluate the dynamic viscoelastic properties in the wide deformational frequency range including the rubbery state. Then, the stress is separated into the nonbonding stress and the bonding stress. We confirm that the contribution of the nonbonding stress is larger at lower temperatures. On the other hand, the contribution of the bonding stress is larger at higher temperatures. Finally, analyzing a change of microscopic structure in dynamic oscillatory deformation, we determine that the temperature/frequency dependence of bond stress response to a dynamic oscillatory deformation depends on the temperature dependence of the average bond length in the equilibrium structure and the temperature/frequency dependence of bond orientation. We show that our simulation is a useful tool for studying the microscopic properties of a cross-linked polymer.
Biological activity of new flavonoid from Hieracium pilosella L.
Authors: Gawrońska-Grzywacz Monika , Krzaczek Tadeusz , Nowak Renata , Los Renata , Malm Anna , Cyranka Małgorzata , Rzeski Wojciech 
Published: March 2011

Abstract
Hieracium pilosella L. (Asteraceae) is a well-known plant used in ethno-medicine as its inflorescences are particularly rich in beneficial polyphenolics. This research aimed to elucidate the structure of a new flavone glycoside isolated from the inflorescences of Hieracium pilosella and evaluate its antioxidant, antimicrobial and antiproliferative activities. The chromatographic methods were successfully applied to isolate the new flavonoid. Its structure was determined by subsequent UV, NMR and MS experiments and identified as isoetin 4′-O-β-D-glucopyranoside. Free radical scavenging capacity was examined by measuring the scavenging activity of the new isoetin derivative on 2,2-diphenyl-1-picrylhydrazyl (DPPH). The compound was also screened for spectrum of antimicrobial activity using the agar well diffusion method. Minimum inhibitory concentration (MIC) for Pseudomonas aeruginosa ATCC 9027 was performed by the micro-dilution broth method. The antiproliferative effect of tested glycoside was assessed in two human tumor cell lines derived from lung (A549) and colon (HT-29) carcinoma and cell proliferation was determined by means of MTT method. The tested compound showed high antiradical activity, reducing the DPPH? with EC50 7.9 μM (3.7 µg/ml) and exhibited narrow antimicrobial spectrum among tested microorganisms. The compound was active against Pseudomonas aeruginosa ATCC 9027 (MIC 125 μg/ml) which is prone to causing infections that are difficult to treat due to it developing extremely rapid antibiotic resistance. In the antiproliferative studies, cell proliferation of the colon (HT-29) carcinoma cell line was significantly decreased after exposure to the compound. The results indicate that isoetin 4′-O-β-D-glucopyranoside possesses antioxidant capacity and very promising antibacterial activity and could have uses as an effective antipseudomonal agent as well a antiproliferative agent.
Gallbladder actinomycosis: Is it a complication after radiofrequency ablation with transarterial chemoembolization for hepatocellular carcinoma?
Authors: Han Hyung , Choi Sae , Kim Wan , Song Tae , Choi Sang 
Published: March 2011

AbstractA 64-year-old man with a history of gallstones, common bile duct stones, chronic hepatitis B virus infection, and hepatic cirrhosis with a Child-Pugh score B was satisfactorily treated for hepatocellular carcinoma with radiofrequency ablation and transarterial chemoembolization. His course, however, was complicated by gallbladder actinomycosis 14 months after treatment, resulting in acute cholecystitis. Such a chain of events suggests that gallbladder actinomycosis may develop after radiofrequency ablation and transarterial chemoembolization in patients who are known to have gallstones and that asymptomatic gallstones should be treated before the application of nonsurgical, but invasive procedures for hepatocellular carcinoma.
A novel data hiding and reversible scheme using SMN blocks in VQ-compressed images
Authors: Huang C. , Wang W. , Wang S. 
Published: March 2011

AbstractData hiding is a technique for embedding secret data into cover media. It is important to multimedia security and has been widely studied. Reversible data hiding methods are becoming prevalent in the area because they can reconstruct the original cover image while extracting the embedded data. In this paper, we propose a new reversible method for vector quantization (VQ) compressed images. Our method takes advantages of the relationship among the side match neighbouring (SMN) blocks to achieve reversibility. The experimental results show that the proposed method has higher compression rate and larger capacity than other existing reversible methods.
Optimal polar image sampling
Authors: Dinčić M. , Perić Z. , Jovanović A. 
Published: March 2011

AbstractIn this paper, a problem of efficient image sampling (deployment of image sensors) is considered. This problem is solved using techniques of two-dimensional quantization in polar coordinates, taking into account human visual system (HVS) and eye sensitivity function. The optimal radial compression function for polar quantization is derived. Optimization of the number of the phase levels for each amplitude level is done. Using optimal radial compression function and optimal number of phase levels for each amplitude level, optimal polar quantization is defined. Using deployment of quantization cells for the optimal polar quantization, deployment of image sensors is done, and therefore optimal polar image sampling is obtained. It is shown that our solution (the optimal polar sampling) has many advantages compared to presently used solutions, based on the log-polar sampling. The optimal polar sampling gives higher SNR (signal-to-noise ratio), compared to the log-polar sampling, for the same number of sensors. Also, the optimal polar sampling needs smaller number of sensors, to achieve the same SNR, compared to the log-polar sampling. Furthermore, with the optimal polar sampling, points in the image middle can be sampled, which is not valid for the log-polar sampling. This is very important since human eye is the most sensitive to these points, and therefore the optimal polar sampling gives better subjective quality.
A literature review on computational models for laminated composite and sandwich panels
Authors: Kreja Ireneusz 
Published: March 2011

AbstractThe present paper is devoted to a state-of-the-art review on the computational treatment of laminated composite and sandwich panels. Over two hundred texts have been included in the survey with the focus put on theoretical models for multilayered plates and shells, and FEM implementation of various computational concepts. As a result of the review, one could notice a lack of a single numerical model capable for a universal representation of all layered composite and sandwich panels. Usually, with the increase of the range of rotations considered in the particular model, one can observe the decrease of the degree of complexity of the through-the-thickness representation of deformation profiles.
Uniquely Human: The Ethics of the Imago Dei in Genesis 1–11
Authors: Schuele Andreas 
Published: March 2011

Abstract: Wentzel van Huyssteen proposes an intriguing reinterpretation of the biblical symbol of the imago Dei, according to which the purpose of humankind as created in the image of God is “to set forth the presence of God in this world.” It is not one particular aspect of human life that is associated with the imago Dei, such as rationality and reason; rather, van Huyssteen invites us to consider the complexity of human life in its evolutionary, biological, social, and ethical dimensions as an expression of the imago Dei. This article explores how his ideas resonate with a historical-critical reading of the pertinent passages in Genesis 1–11. It has often been overlooked that the imago Dei in primeval history is deeply embedded in the priestly account of how life—human and other—is created and how it unfolds. As such, the imago Dei appears in contexts that describe the relationships between humans and animals, men and women, parents and children, and, in a general ethical sense, between neighbours. Humans are called images of God because they are capable of creating, shaping, and changing the networks of relation that connect them with each other and with the rest of creation. It is in these networks that humans fill the world with the kind of life that sets forth divine presence in the world.
Ossification of the posterior longitudinal ligament in the cervical spine: an 11-year comprehensive national epidemiology study
Authors: Wu Jau-Ching , Liu Laura , Chen Yu-Chun , Huang Wen-Cheng , Chen Tzeng-Ji , Cheng Henrich 
Published: March 2011

Object
This study aimed to calculate the incidence and prevalence of ossification of the posterior longitudinal ligament (OPLL) in the cervical spine with its comorbid disability.

Methods
Using an 11-year nationwide database in Taiwan (National Health Insurance Research Database), this retrospective study cohort analyzed the incidences of cervical OPLL causing hospitalization. All patients admitted for the diagnosis of OPLL, regardless of surgery, were identified. Age- and sex-specific incidences, Poisson regression, and multivariate logistic regression analysis were conducted.

Results
Between 1997 and 2007 covering 241,800,725.8 person-years, 1651 patients were admitted for OPLL. The overall incidence of OPLL-related admission was 6.1 per 1 million person-years. Specifically, male sex and older age were associated with higher OPLL incidences (both p < 0.001). Among the 1651 OPLL patients, 542 (32.8%) received conservative management, 612 (37.1%) had anterior only surgery, 353 (21.4%) had posterior only surgery, and 144 (8.7%) had anterior and posterior surgery. Eighty-five patients were moderately to severely disabled (5.2% cumulative incidence rate). The incidences of disability varied by age, in a decreasing trend, except for the 60- to 69-year-old age group (p = 0.05). Patients who received posterior-only surgery were more likely to have disability.

Conclusions
In a large cohort of the Chinese population, the incidence of cervical OPLL-related admission is 6.1 per 1 million person-years, and the prevalence rate is 7.7 per 100,000 person-years. Higher incidences are observed in elderly and male patients, which implies the disease's degenerative nature. After adjustments for demographics, the incidences and trends of OPLL-related comorbid disability are associated with age and surgical approaches.
Missile injury to the pediatric brain in conflict zones
Authors: Wani Abrar A. , Ramzan Altaf U. , Malik Nayil K. , Qayoom Abdul , Nizami Furqan A. , Kirmani Altaf R. , Wani M. Afzal 
Published: March 2011

Object
This study was conducted both prospectively and retrospectively at one center over a period of 8 years. The population consisted of all patients with both an age 18 years or younger and a diagnosed penetrating missile injury (PMI) during the study interval. The authors analyzed factors determining outcome and demographic trends in this population, and they compared them with those in the more developed world

Methods
Fifty-one patients were the victims of armed conflict, although no one was directly a party to any battle. This mechanism of injury is in strong opposition to data in the literature from developed countries, in which most missile injuries are the result of suicide or homicide or are even sports related. Moreover, all previous studies on the pediatric population have considered only injuries from gunshots, but authors of the current study have included injuries from other penetrating missiles as well.

Results
On cross tabulation analysis using the chi-square test, the factors shown to correlate with outcome included the Glasgow Coma Scale (GCS) score, pupillary abnormalities, patient age, hemodynamic status, and bihemispheric damage. On multinomial regression analysis, the two strongest predictors of death were GCS score and pupillary abnormalities. The GCS score and hemodynamic status were the strongest predictors of disability.

Conclusions
There was no difference in the prognostic factors for PMI between developing or more developed countries. Glasgow Coma Scale score, pupillary abnormalities, and hemodynamic status were the strongest predictors of outcome. In conflict zones in developing countries the victims were mostly innocent bystanders, whereas in the more developed countries homicides and suicides were the leading etiological factors.
Institutional experience with 500 cases of surgically treated pediatric Chiari malformation Type I
Authors: Tubbs R. Shane , Beckman Joshua , Naftel Robert P. , Chern Joshua J. , Wellons John C. , Rozzelle Curtis J. , Blount Jeffrey P. , Oakes W. Jerry 
Published: March 2011

Object
The diagnosis and treatment of Chiari malformation Type I (CM-I) has evolved over the last few decades. The authors present their surgical experience of over 2 decades of treating children with this form of hindbrain herniation.

Methods
The authors conducted a retrospective review of their institutional experience with the surgical treatment of the pediatric CM-I from 1989 to 2010.

Results
The 2 most common presentations were headache/neck pain (40%) and scoliosis (18%). Common associated diagnoses included neurofibromatosis Type 1 (5%) and idiopathic growth hormone deficiency (4.2%). Spine anomalies included scoliosis (18%), retroversion of the odontoid process (24%), Klippel-Feil anomaly (3%), and atlantooccipital fusion (8%). Approximately 3% of patients had a known family member with CM-I. Hydrocephalus was present in 48 patients (9.6%). Syringomyelia was present in 285 patients (57%), and at operation, 12% of patients with syringomyelia were found to have an arachnoid veil occluding the fourth ventricular outlet. Fifteen patients (3%) have undergone reoperation for continued symptoms or persistent large syringomyelia. The most likely symptoms and signs to resolve following surgery were Valsalva-induced headache and syringomyelia. The average hospital stay and “return to school” time were 3 and 12 days, respectively. The follow-up for this group ranged from 2 months to 15 years (mean 5 years). Complications occurred in 2.4% of cases; there was no mortality. No patient required acute return to the operating room, and no blood transfusions were performed.

Conclusions
The authors believe this to be the largest reported series of surgically treated pediatric CM-I patients and hope that their experience will be of use to others who treat this surgical entity.
Conservative management of ossification of the posterior longitudinal ligament
Authors: Pham Martin H. , Attenello Frank J. , Lucas Joshua , He Shuhan , Stapleton Christopher J. , Hsieh Patrick C. 
Published: March 2011

Object
Ossification of the posterior longitudinal ligament (OPLL) can result in significant myelopathy. Surgical treatment for OPLL has been extensively documented in the literature, but less data exist on conservative management of this condition.

Methods
The authors conducted a systematic review to identify all reported cases of OPLL that were conservatively managed without surgery.

Results
The review yielded 11 published studies reporting on a total of 480 patients (range per study 1–359 patients) over a mean follow-up period of 14.6 years (range 0.4–26 years). Of these 480 patients, 348 (72.5%) were without myelopathy on initial presentation, whereas 76 patients (15.8%) had signs of myelopathy; in 56 cases (15.8%), the presence of myelopathy was not specified. The mean aggregate Japanese Orthopaedic Association score on presentation for 111 patients was 15.3. Data available for 330 patients who initially presented without myelopathy showed progression to myelopathy in 55 (16.7%), whereas the other 275 (83.3%) remained progression free. In the 76 patients presenting with myelopathy, 37 (48.7%) showed clinical progression, whereas 39 (51.5%) remained clinically unchanged or improved.

Conclusions
Patients who present without myelopathy have a high chance of remaining progression free. Those who already have signs of myelopathy at presentation may benefit from surgery due to a higher rate of progression over continued follow-up.
Laminoplasty outcomes: is there a difference between patients with degenerative stenosis and those with ossification of the posterior longitudinal ligament?
Authors: Meyer Scott A. , Wu Jau-Ching , Mummaneni Praveen V. 
Published: March 2011

Object
Two common causes of cervical myelopathy include degenerative stenosis and ossification of the posterior longitudinal ligament (OPLL). It has been postulated that patients with OPLL have more complications and worse outcomes than those with degenerative stenosis. The authors sought to compare the surgical results of laminoplasty in the treatment of cervical stenosis with myelopathy due to either degenerative changes or segmental OPLL.

Methods
The authors conducted a retrospective review of 40 instrumented laminoplasty cases performed at a single institution over a 4-year period to treat cervical myelopathy without kyphosis. Twelve of these patients had degenerative cervical stenotic myelopathy ([CSM]; degenerative group), and the remaining 28 had segmental OPLL (OPLL group). The 2 groups had statistically similar demographic characteristics and number of treated levels (mean 3.9 surgically treated levels; p > 0.05). The authors collected perioperative and follow-up data, including radiographic results.

Results
The overall clinical follow-up rate was 88%, and the mean clinical follow-up duration was 16.4 months. The mean radiographic follow-up rate was 83%, and the mean length of radiographic follow-up was 9.3 months. There were no significant differences in the estimated blood loss (EBL) or length of hospital stay (LOS) between the groups (p > 0.05). The mean EBL and LOS for the degenerative group were 206 ml and 3.7 days, respectively. The mean EBL and LOS for the OPLL group were 155 ml and 4 days, respectively. There was a statistically significant improvement of more than one grade in the Nurick score for both groups following surgery (p < 0.05). The Nurick score improvement was not statistically different between the groups (p > 0.05). The visual analog scale (VAS) neck pain scores were similar between groups pre- and postoperatively (p > 0.05). The complication rates were not statistically different between groups either (p > 0.05). Radiographically, both groups lost extension range of motion (ROM) following laminoplasty, but this change was not statistically significant (p > 0.05).

Conclusions
Patients with CSM due to either degenerative disease or segmental OPLL have similar perioperative results and neurological outcomes with laminoplasty. The VAS neck pain scores did not improve significantly with laminoplasty for either group. Laminoplasty may limit extension ROM.