bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid Transfer to HDL is Higher in Marathon Runners than in Sedentary Subjects, but is Acutely Inhibited During the Run
Authors: Vaisberg Mauro , Bachi André L. L. , Latrilha Conceição , Dioguardi Giuseppe S. , Bydlowski Sergio P. , Maranhão Raul C. 
Published: June 2012

AbstractAlthough exercise increases HDL‐cholesterol, exercise‐induced changes in HDL metabolism have been little explored. Lipid transfer to HDL is essential for HDL's role in reverse cholesterol transport. We investigated the effects of acute exhaustive exercise on lipid transfer to HDL. We compared plasma lipid, apolipoprotein and cytokine levels and in vitro transfer of four lipids from a radioactively labeled lipid donor nanoemulsion to HDL in sedentary individuals (n = 28) and in marathon runners (n = 14) at baseline, immediately after and 72 h after a marathon. While HDL‐cholesterol concentrations and apo A1 levels were higher in marathon runners, LDL‐cholesterol, apo B and triacylglycerol levels were similar in both groups. Transfers of non‐esterified cholesterol [6.8 (5.7–7.2) vs. 5.2 (4.5–6), p = 0.001], phospholipids [21.7 (20.4–22.2) vs. 8.2 (7.7–8.9), p = 0.0001] and triacylglycerol [3.7 (3.1–4) vs. 1.3 (0.8–1.7), p = 0.0001] were higher in marathon runners, but esterified‐cholesterol transfer was similar. Immediately after the marathon, LDL‐ and HDL‐cholesterol concentrations and apo A1 levels were unchanged, but apo B and triacylglycerol levels increased. Lipid transfer of non‐esterified cholesterol [6.8 (5.7–7.2) vs. 5.8 (4.9–6.6), p = 0.0001], phospholipids [21.7 (20.4–22.2) vs. 19.1 (18.6–19.3), p = 0.0001], esterified‐cholesterol [3.2 (2.2–3.8) vs. 2.3 (2–2.9), p = 0.02] and triacylglycerol [3.7 (3.1–4) vs. 2.6 (2.1–2.8), p = 0.0001] to HDL were all reduced immediately after the marathon but returned to baseline 72 h later. Running a marathon increased IL‐6 and TNF‐α levels, but after 72 h these values returned to baseline. Lipid transfer, except esterified‐cholesterol transfer, was higher in marathon runners than in sedentary individuals, but the marathon itself acutely inhibited lipid transfer. In light of these novel observations, further study is required to clarify how these metabolic changes can influence HDL composition and anti‐atherogenic function.
Tibet forcing of mid-Pleistocene synchronous enhancement of East Asian winter and summer monsoons revealed by Chinese loess record
Authors: Han Wenxia , Fang Xiaomin , Berger André 
Published: June 2012

AbstractThe mid-Pleistocene transition (MPT) of the global climate system, marked by a shift of previously dominant 41-ka cycles to lately dominant 100-ka cycles roughly in the mid-Pleistocene, is one of the fundamental enigma in the Quaternary climate evolution. The process and origin of the MPT remain of persistent interest and conjecture. Here we present high-resolution astronomically tuned magnetic susceptibility (MS) and grain‐size records from a complete loess–paleosol sequence at Chaona on the central Chinese Loess Plateau. These two proxies are well-known sensitive indicators to the East Asian summer and winter monsoons, respectively. The records reveal a remarkable two-step simultaneous enhancement of the East Asian summer and winter monsoons at 0.9 Ma and 0.64 Ma, respectively, accompanied with an onset of a clear 100-ka cycle at 0.9 Ma and of a final, predominant 100-ka cycle starting at 0.64 Ma. The mid-Pleistocene stepwise rapid uplift of the Tibetan Plateau could be the mechanism driving the simultaneous enhancement of East Asian summer and winter monsoons and the shift of the periodicities during the MPT by complex positive feedbacks.
The role of the circadian clock system in nutrition and metabolism
Authors: Cagampang Felino R. , Bruce Kimberley D. 
Published: June 2012

Mammals have an endogenous timing system in the suprachiasmatic nuclei (SCN) of the hypothalamic region of the brain. This internal clock system is composed of an intracellular feedback loop that drives the expression of molecular components and their constitutive protein products to oscillate over a period of about 24 h (hence the term ‘circadian’). These circadian oscillations bring about rhythmic changes in downstream molecular pathways and physiological processes such as those involved in nutrition and metabolism. It is now emerging that the molecular components of the clock system are also found within the cells of peripheral tissues, including the gastrointestinal tract, liver and pancreas. The present review examines their role in regulating nutritional and metabolic processes. In turn, metabolic status and feeding cycles are able to feed back onto the circadian clock in the SCN and in peripheral tissues. This feedback mechanism maintains the integrity and temporal coordination between various components of the circadian clock system. Thus, alterations in environmental cues could disrupt normal clock function, which may have profound effects on the health and well-being of an individual.
Increases in fruit intakes in older low consumers of fruit following two community-based repeated exposure interventions
Authors: Appleton K. M. 
Published: June 2012

The present study investigated the value of two repeated exposure interventions for increasing intakes of fruit in older people. A total of ninety-five participants (aged 65 years and over) were randomised to receive either one (E1), five (E5) or five plus (E5+) exposures to fruit over a 5-week period. Fruit exposures occurred in community-based church and social groups, through fruit-tasting sessions involving familiar fruits and novel fruit products and dishes (E1, E5, E5+), and through fruit provision (E5+). Daily intakes of fruit and vegetables were assessed before and after all interventions. Liking for all fruits was also measured during repeated exposure (E5, E5+). In low consumers of fruit (one portion/d or less), fruit intakes increased significantly in the repeated exposure groups (E5, E5+) (t(30) = 5·79, P< 0·01), but did not change in the E1 group (t(16) = 0·29, P= 0·78). No differences were found between E5 and E5+ groups (F(3,87) = 1·22, P= 0·31). Similar effects were also found in fruit and vegetable intakes. No effects were found in other participants. Also, no changes in liking were found. These findings suggest that compared to single exposure, repeated exposure to fruit via fruit-tasting sessions once per week for 5 weeks in a community setting significantly improved fruit intakes, and fruit and vegetable intakes in older low consumers of fruit, although no benefits of additional fruit provision were found. Repeated exposure was also easy to implement, of low cost and enjoyable.
Effect of different levels of supplied cobalt on the fatty acid composition of bovine milk
Authors: Karlengen Inger J. , Taugbøl Ole , Salbu Brit , Aastveit Are H. , Harstad Odd M. 
Published: June 2012

In previous studies, administration of high amounts of Co decreased the proportion of MUFA in bovine milk. The present study was conducted to examine the amount of Co needed to obtain this effect. High-yielding dairy cows (n4), equipped with ruminal cannulas, were used in a 4 × 4 Latin square design study. The basal diet consisted of concentrate mixture (9 kg/d) without added Co and grass silage (ad libitum). The following four levels of Co were administrated as cobalt acetate dissolved in distilled water: no Co (treatment 1, T1); 4·0 mg Co/d (T2); 380 mg Co/d (T3); 5300 mg Co/d (T4). Each period lasted for 18 d, including 11 d of treatment. During the treatment periods, the solutions were continuously infused into the rumen. Milk yield and milk concentration of fat, fatty acids (FA), protein, lactose, Co, Zn, Fe and Cu were determined. Blood plasma was analysed with respect to FA, Co, Zn, Fe and Cu. Feed intake and total tract digestibility of feed components were also determined. There was a linear effect of increasing the level of Co on milk FA composition. The effects of Co on FA composition in blood were insignificant compared with the effects on milk. In milk fat, the concentration ofcis-9-18 : 1 was reduced by as much as 38 % on T4 compared with T1. Feed intake and milk yield were negatively affected by increasing the Co level.
SECULAR TRENDS IN BODY COMPOSITION AND FREQUENCY OF OVERWEIGHT AND OBESITY IN BOYS AGED 3–18 FROM KRAKOW, POLAND, WITHIN THE LAST 30 YEARS (FROM 1983 TO 2010)
Authors: KOWAL MAŁGORZATA , KRYST ŁUKASZ , SOBIECKI JAN , WORONKOWICZ AGNIESZKA 
Published: June 2012

SummaryThe aim of this study was to examine the changes in body composition (fatness and muscle and bone mass) and BMI in three cohorts of boys living in Krakow, Poland, over the last 30 years, and to assess how overweight and obesity frequencies have developed over the period. The anthropological survey was conducted in 2010, and comprised 1863 boys from Krakow aged 3–18 years. The analysis compared the latest measurements of selected skinfold thicknesses, BMI, total body muscle mass and bone mass with the results of surveys from 1983 (N=1934) and 2000 (N=2323). The frequency of overweight and obesity was assessed for the last survey series, and their trends determined for the years 1983–2000 and 2000–2010. The analysis of fat tissue distribution showed that the boys from the 2010 cohort, as compared with those examined in 2000, had a higher trunk adiposity, as manifested by greater thickness of subscapular and suprailiac skinfold thicknesses, and boasted a larger muscle mass and lower bone mass. The survey results also showed that, from 1983 to 2000, the percentage of overweight boys increased slightly (from 11.69% to 12.48%), whereas the frequency of obesity did not change. Over the last decade, the percentage of overweight people has increased to 15.94%, and the frequency of obesity has doubled, equalling 4.94% in 2010. The last decade has seen a minor trend in boys towards increased trunk adiposity, muscle mass, BMI and prevalence of overweight and obesity, and a slight decrease in bone mass.
Sebaceoma of the auricle
Authors: Jacobson J P , Weisstuch A , Hajdu C , Myssiorek D 
Published: June 2012

AbstractObjective:To report a case of sebaceoma of the auricle, and to discuss the differential diagnosis, histopathological features, surgical management and genetic associations of this entity.Methods:Case report and review of the medical literature.Results:A 79-year-old man presented with a slowly growing lesion of his auricle. Excision of the mass and histopathological review revealed a benign, basaloid, adnexal neoplasm consistent with sebaceoma. Due to its association with Muir–Torre syndrome and increased risk of visceral malignancy, the patient was followed closely for signs of malignancy. At 36 months post-excision, there were no signs of recurrence; thereafter, the patient continued to receive routine cancer surveillance follow up.Conclusion:Sebaceoma is a rarely encountered, benign, adnexal neoplasm which can occur in the head and neck. The treatment is surgical excision, and recurrence is rare. Sebaceoma can occur as part of Muir–Torre syndrome, and in these patients there is an increased risk of other sebaceous lesions and visceral malignancy; thus, genetic testing and surveillance should be strongly considered.
A new species and new records of the lichen genus Pyrenula from Iran
Authors: APTROOT André , VALADBEIGI Tahereh , SIPMAN Harrie J. M. 
Published: June 2012

AbstractThe lichen Pyrenula minutissima is described as new to science from the Hyrcanian forests in northern Iran. In addition, three further, essentially tropical, Pyrenula species are reported for the first time from Iran. An identification key is provided for all eight Pyrenula species now known from Iran.
A new terricolous Trapelia and a new Trapeliopsis (Trapeliaceae, Baeomycetales) from Macaronesia
Authors: APTROOT André , SCHUMM Felix 
Published: June 2012

AbstractTrapeliopsis gymnidiata, a terricolous species from the Canary Islands, is described as new to science. It has previously been confused with T. wallrothii, but differs by the soft, partly decorticate isidia, or rather gymnidia, that leave inconspicuous scars after falling off. Trapeliopsis wallrothii is known only from high mountains in Macaronesia, while T. gymnidiata is a lowland species. Trapelia rubra from Madeira is also described as new to science. It grows in similar places and resembles some morphs of Trapelia coarctata, but differs by the nearly squamulose areoles, the crenulate, seemingly sorediate, apothecium margin that does not become excluded, and especially by the patchy red colour (skyrin) in the medulla.
Prion protein degradation by lichens of the genusCladonia
Authors: BENNETT James P. , RODRIGUEZ Cynthia M. , JOHNSON Christopher J. 
Published: June 2012

AbstractIt has recently been discovered that lichens contain a serine protease capable of degrading the pathogenic prion protein, the etiological agent of prion diseases such as sheep scrapie and cervid chronic wasting disease. Limited methods are available to degrade or inactivate prion disease agents, especially in the environment, and lichens or their serine protease could prove important for management of these diseases. Scant information is available regarding the presence or absence of the protease responsible for degrading prion protein (PrP) in lichen species and, in this study, we tested the hypothesis that PrP degradation activity in lichens is phylogenetically-based by testing 44 species ofCladonialichens, a genus for which a significant portion of the phylogeny is well established. We categorized PrP degradation activity among the 44 species (high, moderate, low or none) and found that activity inCladoniaspecies did not correspond with phylogenetic position of the species. Degradation of PrP did correspond, however, with three classical taxonomic characters within the genus: species with brown apothecia, no usnic acid, and the presence of a cortex. Of the 44 species studied, 18 (41%) had either high or moderate PrP degradation activity, suggesting the protease may be frequent in this genus of lichens.
Fungal-algal interactions inRamalina menziesiiand its associated epiphytic lichen community
Authors: WERTH Silke 
Published: June 2012

AbstractLichens are a fascinating example of a symbiotic mutualism. It is still uncertain which processes guide fungal-photobiont interactions, and whether they are random or of a more complex nature. Here, the fungal-algal interactions inRamalina menziesiiand co-occurring taxa are analyzed by using DNA sequences of the algal Internal Transcribed Spacer region (ITS), to investigate fungal-algal associations in juvenileR. menziesiiand allied species. Algal species were identified by a combination of BLAST searches, median-joining network analysis, and Bayesian phylogenetics. Fungal-algal networks were analyzed for nestedness, both at the species and haplotype level (fungal species vs. algal haplotypes), and the networks were inspected for evidence of compartmentalization. Bayesian phylogenetic trees indicated that the widespread green algaTrebouxia decoloransassociated withR. menziesii, as well as six other fungal species. Four additional fungal species interacted with four different species ofTrebouxia. Only in one out of ten samples were algal haplotypes shared with the nearest neighbours of juvenileR. menziesii. Fungal-algal species interactions were compartmentalized, while at the level of algal haplotypes, nestedness was found. This pattern is similar to the compartmentalization found in other intimately interacting mutualists.
Lecanora subjaponica, a new lichen from China
Authors: LÜ Lei , ZHANG Lu Lu , LIU Xin Li , ZHAO Zun Tian , WANG Hai Ying 
Published: June 2012

AbstractLecanora subjaponica L. Lü & H. Y. Wang from western China is described as new to science. It is the only known Lecanora species having (16–)32-spored asci and it is otherwise characterized by an epruinose, shiny brown apothecial disc, epihymenium lacking granules and the presence of zeorin in addition to atranorin. A worldwide key to the multispored species of Lecanora is also given.
New species, combinations and records of lichenized fungi from the Falkland Islands (Islas Malvinas)
Authors: FRYDAY Alan M. , ØVSTEDAL Dag O. 
Published: June 2012

AbstractTen new species in nine different genera are described from the Falkland Islands (Islas Malvinas): Bryonora granulata with a finely granular thallus containing perlatolic acid; Bryoria mariensis, a terricolous species with norstictic acid and unusual cortex cells; Carbonea hypopurpurea with a K+ purple hypothecium and a thallus containing confluentic and 2′-O-methylperlatolic acids; Caloplaca megalariicola lichenicolous on Megalaria grossa; Cladonia flammea with a red-orange coloration on the lower side of the primary squamules; Cliostomum falklandicum, on rocks and with a dispersed thallus containing only atranorin; Lepraria malouina with usnic and stictic acids; Rimularia andreaeicola, over bryophytes and lacking lichen substances; R. subpsephota, similar to R. psephota but with a discrete white thallus lacking norstictic acid; and Usnea austrocampestris, a straggling species in sect. Neuropogon from the mountain tops. Rimularia andreaeicola is also known from Tierra del Fuego and R. subpsephota from Tierra del Fuego and South Georgia, but the other species are known only from the Falkland Islands. The new combinations Carbonea agellata, C. subdeclinans, Cliostomum aeruginascens and C. violascens are also made; Lecidea interrupta Darb. and Lecidea protracta Darb. are reduced to synonymy with Lecanora xantholeuca (Müll. Arg.) Hertel; Rhizocarpon simillimum is reported for the first time from the Southern Hemisphere, from the Falkland Islands and New Zealand; and Bryoria chalybeiformis is reported for the first time from the Falkland Islands.
Parkinson's disease – pathology, aetiology and diagnosis
Authors: Macphee Graeme JA , Stewart David A 
Published: June 2012

SummaryParkinson's disease is a progressive neurodegenerative condition. There is an increasing incidence and prevalence with advancing age and more cases are predicted as the population ages. Because of likely differing aetiology, genetics and pathology in individual patients, as well as confounding co-morbidities, diagnosis can be difficult even for specialists. We present an overview of the pathology, aetiology and differential diagnosis of Parkinson's disease in older people. The importance of specialist medical input in diagnosis is emphasized.
What can e-learning offer geriatric medicine in the UK?
Authors: Tullo Ellen , Newton Julia , Clapp Alison 
Published: June 2012

SummaryThe expansion of e-learning in medical education is a reflection of the inherent advantages that technology can bring to teaching and learning. Geriatric medicine has taken advantage of some of the benefits associated with e-learning in terms of undergraduate education, specialty training and interdisciplinary training. However, there are further opportunities and challenges to be met for geriatric medicine to make the very most of e-learning. This review outlines the terminology associated with e-learning, summarizes the advantages and potential problems, and considers the evidence base for the efficacy of e-learning. Current use of e-learning amongst professional groups is summarized and recommendations made for expanding the use of e-learning for all healthcare professionals working with older people.
Montreal Cognitive Assessment (MoCA): Validation Study for Vascular Dementia
Authors: Freitas Sandra , Simões Mário R. , Alves Lara , Vicente Margarida , Santana Isabel 
Published: June 2012

AbstractThe Montreal Cognitive Assessment (MoCA) is a brief instrument developed for the screening of milder forms of cognitive impairment, having surpassed the well-known limitations of the MMSE. The aim of the present study was to validate the MoCA as well as its short version, which was proposed by the NINDS-CSN VCI Harmonization Standards for screening Vascular Dementia (VaD) patients. The results, based on a homogeneous sample of 34 VaD patients, indicate that the MoCA is a psychometrically valid and reliable instrument for cognitive screening in VaD patients, showing excellent discriminant validity. Both the full and short versions of the MoCA had excellent diagnostic accuracy in discriminating VaD patients, exhibiting an area under curve (AUC) higher than the MMSE [AUC(MoCA full version) = .950; 95% IC = .868–.988; AUC(MoCA short version) = .936; 95% IC = .849–.981; AUC(MMSE) = .860; 95% IC = .754–.932]. With a cutoff below 17 on the MoCA full version and 8 on the short version, the results for sensitivity, specificity, positive and negative predictive values, and classification accuracy were superior compared to the MMSE. In conclusion, both versions of the MoCA are valid, reliable, sensitive and accurate screening instruments for VaD patients. (JINS, 2012, 18, 1–10)
Kant's Refutation of Idealism: Once More Unto the Breach
Authors: Dicker Georges 
Published: June 2012

AbstractIn ‘Kant's Refutation of Idealism’ (Noûs, 47), I defend a version of the Refutation, pioneered by Paul Guyer inKant and the Claims of Knowledge, whose core idea is that the only way that one can know the order of one's own past experiences, except in certain rare cases, is by correlating them with the successive states of perceived external objects that caused the experiences. Andrew Chignell has offered a probing critique of my reconstruction of Kant's argument (Philosophical Quarterly, 60), and I have responded (Philosophical Quarterly, 61). In a rebuttal of my response, Chignell raises three new objections (Philosophical Quarterly, 61). My purpose in this paper is to reply to these.
Original Sin and Radical Evil: Kierkegaard and Kant
Authors: Fremstedal Roe 
Published: June 2012

AbstractBy comparing the theories of evil found in Kant and Kierkegaard, this article aims to shed new light on Kierkegaard, as well as on the historical and conceptual relations between the two philosophers. The author shows that there is considerable overlap between Kant's doctrine of radical evil and Kierkegaard's views on guilt and sin and argues that Kierkegaard approved of the doctrine of radical evil. Although Kierkegaard's distinction between guilt and sin breaks radically with Kant, there are more Kantian elements in Kierkegaard than was shown by earlier scholarship. Finally, Kierkegaard provides an alternative solution to the problem of the universality of guilt, a problem much discussed in the literature on Kant.
Rawls and Kantian Constructivism
Authors: Kaufman Alexander 
Published: June 2012

AbstractJohn Rawls's account of Kantian constructivism is perhaps his most striking contribution to ethics. In this paper, I examine the relation between Rawls's constructivism and its foundation in Kantian intuitions. In particular, I focus on the progressive influence on Rawls's approach of the Kantian intuition that the substance of morality is best understood as constructed by free and equal people under fair conditions. Rawls's focus on this Kantian intuition, I argue, motivates the focus on social contract that grounds both his accounts of the original position and of reflective equilibrium. Critics, including Onora O'Neill and Larry Krasnoff, object that Rawls's view distorts various aspects of Kantian moral reasoning. I argue that these objections (i) exaggerate the distinctions between Kant's and Rawls's decision procedures and (ii) reflect an unnecessarily constricted view of Kant's moral thought.
Happiness Proportioned to Virtue: Kant and the Highest Good
Authors: O'Connell Eoin 
Published: June 2012

AbstractThis paper considers two contenders for the title of highest good in Kant's theory of practical reason: happiness proportioned to virtue and the maximization of happiness and virtue. I defend the ‘proportionality thesis’ against criticisms made by Andrews Reath and others, and show how it resolves a dualism between prudential and moral practical reasoning. By distinguishing between the highest good as a principle of evaluation and an object of agency, I conclude that the maximization of happiness and virtue is a corollary of the instantiation of the proportionality thesis.