bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of pathological gambling behaviours in parents population in Nigeria
Authors: Ede Moses Onyemaechi , Nwosu Kingsley Chinaza , Okeke Chinedu Ifedi , Oneli Joy Obiageli 
Published: April 2024

AbstractThe increasing incidence of psychological pains, burnout, and anxiety among gamblers in Nigeria is high. This is because pathological gambling (PG) is on the rise and it is linked to many social vices such as stealing, drug abuse, and sexual abuse. It is important to investigate the trajectories of PG in Nigeria. A cross-sectional survey design was employed in our study with 197 participants sampled from 28 gambling venues in Nigeria made up the study’s sample size. Of the 197, 131 (66.5%) were males and 66 (33.5%) were females. 50 (25.4%) were within the age range of 20–30 years, 42 (21.3%) were within 31–40 years, 40 (20.3%) were within 41–50 years, 35 (17.8%) were within 51–60 years, and 30 (15.2%) were within 61 and above. Using the hierarchical regression analysis, our finding revealed a significant association between psychological distress and our respondents’ pathological gambling behaviour whereas none of the sociodemographic variables made a significant contribution to their pathological gambling behaviour. We concluded that gamblers’ psychological well-being is crucial to understanding their problematic gambling behaviours in the context of a developing nation such as Nigeria, and that this could be similar among our respondents. Implications of our findings were highlighted.
The design and evaluation of gamified online role-play as a telehealth training strategy in dental education: an explanatory sequential mixed-methods study
Authors: Teerawongpairoj Chayanid , Tantipoj Chanita , Sipiyaruk Kawin 
Published: April 2024

AbstractTo evaluate user perceptions and educational impact of gamified online role-play in teledentistry as well as to construct a conceptual framework highlighting how to design this interactive learning strategy, this research employed an explanatory sequential mixed-methods design. Participants were requested to complete self-perceived assessments toward confidence and awareness in teledentistry before and after participating in a gamified online role-play. They were also asked to complete a satisfaction questionnaire and participate in an in-depth interview to investigate their learning experience. The data were analyzed using descriptive statistics, paired sample t-test, one-way analysis of variance, and framework analysis. There were 18 participants who completed self-perceived assessments and satisfaction questionnaire, in which 12 of them participated in a semi-structured interview. There were statistically significant increases in self-perceived confidence and awareness after participating in the gamified online role-play (P < 0.001). In addition, the participants were likely to be satisfied with this learning strategy, where usefulness was perceived as the most positive aspect with a score of 4.44 out of 5, followed by ease of use (4.40) and enjoyment (4.03). The conceptual framework constructed from the qualitative findings has revealed five key elements in designing a gamified online role-play, including learner profile, learning settings, pedagogical components, interactive functions, and educational impact. The gamified online role-play has demonstrated its potential in improving self-perceived confidence and awareness in teledentistry. The conceptual framework developed in this research could be considered to design and implement a gamified online role-play in dental education. This research provides valuable evidence on the educational impact of gamified online role-play in teledentistry and how it could be designed and implemented in dental education. This information would be supportive for dental instructors or educators who are considering to implement teledentistry training in their practice.
Enhanced Stability, Superior Anti-Corrosive, and Tribological Performance of Al2O3 Water-based Nanofluid Lubricants with Tannic Acid and Carboxymethyl Cellulose over SDBS as Surfactant
Authors: Rahmadiawan Dieter , Shi Shih-Chen 
Published: April 2024

AbstractIn this research work, the stability, tribological, and corrosion properties of a water-based Al2O3 nanofluid (0.5 wt%) formulated with tannin acid (TA) and carboxymethyl cellulose (CMC) as dispersants or surfactants were investigated. For comparative purposes, sodium dodecylbenzene sulfonate (SDBS) was also incorporated. The stability of the nanofluid was assessed through zeta potential measurements and photo-capturing, revealing the effectiveness of TA and CMC in preventing nanoparticle agglomeration. Tribological properties were examined using a pin-on-disk apparatus, highlighting the tribofilm of Al2O3 that enhanced lubricating properties of the nanofluid by the SEM, resulting in reduced friction and wear of the contacting surfaces. Sample with the addition of both TA and CMC exhibited the best tribological performance, with a ~ 20% reduction in the friction coefficient and a 59% improvement in wear rate compared to neat nanofluid without TA and CMC. Additionally, the corrosion resistance of the nanofluids were evaluated via weight loss and electrochemical impedance spectroscopy. The nanofluid sample containing both TA and CMC exhibited the lowest corrosion rate, with 97.6% improvement compared to sample without them. This study provides valuable insights into the potential applications of TA and CMC-based Al2O3 nanofluids as effective and environmentally friendly solutions for coolant or lubrication in cutting processes.
Etiologic evaluation and pregnancy outcomes of fetal growth restriction (FGR) associated with structural malformations
Authors: Wu Xiaoqing , He Shuqiong , Shen Qingmei , Xu Shiyi , Guo Danhua , Liang Bin , Wang Xinrui , Cao Hua , Huang Hailong , Xu Liangpu 
Published: April 2024

AbstractThis study aimed to evaluate the etiology and pregnancy outcomes of fetuses underwent invasive prenatal diagnosis for fetal growth restriction (FGR) accompanied by structural malformations. Data from 130 pregnancies referred for prenatal diagnosis for FGR accompanied by structural malformations were obtained between July 2011 and July 2023. Traditional karyotyping was conducted for all the subjects. A total of 37 (28.5%) cases of chromosomal abnormalities were detected by karyotyping, including 30 cases of numerical anomalies and seven cases of unbalanced structural anomalies. Trisomy 18 was the most common abnormalities, accounting for 51.4%, significantly higher than any other chromosomal abnormality. The cohort was predominantly comprised of early-onset FGR (88.5%) compared to late-onset FGR (11.5%). The incidences of chromosomal abnormalities in this two groups were 29.6% (34/115) and 20.0% (3/15), respectively (p > 0.05). The majority (74.6%, 97/130) of the cohort were affected by a single system malformation, with chromosomal abnormalities found in 19.6% (19/97) of cases. In pregnancies of structural malformations involving two and multiple systems, the frequencies were 56.5% (13/23), and 50.0% (5/10), respectively. Single nucleotide polymorphism array (SNP array) was performed in parallel for 65 cases, revealing additional 7.7% cases of copy number variants (CNVs) compared to karyotyping. Polymerase chain reaction (PCR) was used for detection of cytomegalovirus (CMV) DNA in 92 cases. All fetuses with FGR associated with two or more system malformations were either terminated or stillborn, irrespective of chromosomal aberrations. Conversely, 71.8% of pregnancies with a single-system malformation and normal genetic testing results resulted in live births. Furthermore, two (2.2%) cases tested positive for CMV DNA, leading to one termination and one case of serious developmental disorder after birth. Our study suggests that structural malformations associated with FGR are more likely to affect a single organ system. When multiple systems are involved, the incidence of chromosomal abnormalities and termination rates are notably high. We advocate for the use of CMA and CMV DNA examinations in FGR cases undergo invasive prenatal diagnosis, as these tests can provide valuable insights for etiological exploration and pregnancy management guidance.
PAFAH1B3 is a KLF9 target gene that promotes proliferation and metastasis in pancreatic cancer
Authors: Dong Cairong , Yao Jinping , Wu Zhipeng , Hu Junwen , Sun Liang , Wu Zhengyi , Yan Jinlong , Yin Xiangbao 
Published: April 2024

AbstractPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies. Uncontrolled cell proliferation, invasion and migration of pancreatic cancer cells are the fundamental causes of death in PDAC patients. Our previous studies showed that KLF9 inhibits the proliferation, invasion and migration of pancreatic cancer cells. However, the underlying mechanisms are not fully understood. In this study, we found that platelet-activating factor acetylhydrolase IB3 (PAFAH1B3) is highly expressed in pancreatic cancer tissues and cells. In vitro and in vivo studies showed that overexpression of PAFAH1B3 promoted the proliferation and invasion of pancreatic cancer cells, while downregulation of PAFAH1B3 inhibited these processes. We found that KLF9 expression is negatively correlated with PAFAH1B3 expression in pancreatic cancer tissues and cells. Western blotting revealed that KLF9 negatively regulates the expression of PAFAH1B3 in pancreatic cancer tissues and cells. Rescue experiments showed that overexpression of PAFAH1B3 could partially attenuate the suppression of pancreatic cancer cell proliferation, invasion and migration induced by KLF9 overexpression. Finally, chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assays were carried out, and the results showed that KLF9 directly binds to the promoter of PAFAH1B3 and inhibits its transcriptional activity. In conclusion, our study indicated that KLF9 can inhibit the proliferation, invasion, migration and metastasis of pancreatic cancer cells by inhibiting PAFAH1B3.
Eocene amber provides the first fossil record and bridges distributional gap in the rare genus Robsonomyia (Diptera: Keroplatidae)
Authors: Pełczyńska Alicja , Krzemiński Wiesław , Blagoderov Vladimir , Vilhelmsen Lars , Soszyńska Agnieszka 
Published: April 2024

AbstractUntil now, the genus Robsonomyia was represented by two extant species: R. reducta Matile & Vockeroth, 1980 from North America and R. sciaraeformis (Okada, 1939) from Asia. This paper presents the first fossil members of the genus Robsonomyia, which is also the first record from Europe. Two new fossil species from Baltic amber are described: R. baltica Pełczyńska, Krzemiński & Blagoderov, sp. nov. and R. henningseni Pełczyńska, Krzemiński & Blagoderov, sp. nov.. The presence of fossil Robsonomyia spp. on the European continent suggests Holarctic distribution of the genus in the past. We also discuss possible pathways of its intercontinental dispersion.
Experimental investigation of drag loss behavior of dip-lubricated wet clutches for building a data-driven prediction model
Authors: Pointner-Gabriel Lukas , Menzel Max , Voelkel Katharina , Schneider Thomas , Stahl Karsten 
Published: April 2024

AbstractFundamental knowledge of wet clutches’ drag loss behavior is essential for designing low-loss clutch systems. In contrast to the widely investigated injection lubrication, more comprehensive knowledge is needed on the drag loss behavior of dip-lubricated wet clutches. In the development phase, data-driven models allow drag loss predictions with low computational effort and, at the same time, sufficient accuracy. Therefore, this study aimed to deepen and expand knowledge of the drag loss behavior of dip-lubricated wet clutches based on experimental investigations. Moreover, the investigations were designed and conducted so that the generated data and findings can be used in further research for building data-driven prediction models. The investigations were conducted on two clutch systems from automotive and industrial applications. The practice-relevant parameters of clearance, oil level, oil viscosity, and plate shape were investigated based on a mixed-level full factorial design. The evaluation shows that a reduction in drag loss can be achieved primarily by increasing the clearance, reducing the oil viscosity, and choosing waved plates. The obtained drag loss behavior can be traced back to the form of oil displacement from the gaps. The displacement process, in turn, is influenced by the operating and geometry parameters. Although the flow in the gaps develops differently for dip and injection lubrication over differential speed, the study shows comparable integral effects of the influencing parameters for both types of lubrication. The generated datasets contain the investigated parameters as features and characteristic drag loss values as targets. The findings can support the selection and configuration of the machine learning algorithm and the validation of the trained models. The described procedure can serve as a template for generating and analyzing datasets for data-driven modeling of wet clutches’ drag losses.
Damage and reliability analysis of double-arch tunnel without a middle pilot tunnel under blast load
Authors: Jian Bingxi , Tao Tiejun , Song Shuai , Xie Caijin , Tian Xingchao , Li Guoqing , Wan Antong 
Published: April 2024

AbstractIn this study, a new type of multi-arch tunnel construction method is proposed. This effort is undertaken due to the many disadvantages of the traditional multi-arch tunnel construction method. Furthermore, this method omits the construction of a middle pilot tunnel, and it has the advantages of safety, high efficiency, and being economical. When using the method of continuous arch tunneling without a middle pilot tunnel, the blasting of the first tunnel and the following tunnel has a greater impact on the surrounding rock damage, as well as on the supporting structure of the same cross-section. Therefore, this study uses LS-DYNA finite element software to construct a three-dimensional numerical model. In addition, the perimeter rock damage law and mechanical response characteristics of the supporting structure in the same cross-section of the first tunnel, as well as the following tunnel after blasting without a middle pilot tunnel, are analyzed. At the same time, the results of the study are based on optimizing the blasting program, and these are then applied to the field. Through the results, it is found that, after blasting a continuous arch tunnel without a medial pilot tunnel, the surrounding rock damage in the arch cross-region of the double-arch tunnel (where the arch top and the arch shoulder are more significant) and the effective stress of the supporting structure exceed the strength design value. In addition, the maximum adequate pressure is distributed in the medial diaphragm wall. With the optimized blasting scheme, the range of the peripheral rock damage is reduced by a maximum of 67%, and the effective stress in the supporting structure is reduced by 25.9–64.8%. The research results are of great significance in terms of improving construction safety, economic efficiency, and project quality, as well as in promoting the research and development of new work methods for double-arch tunnels.
Urban rooftops near sports pitches provide a safe haven for a declining shorebird
Authors: Löffler Franz , Brüggeshemke Jonas , Freienstein Felix Maximilian , Kämpfer Steffen , Fartmann Thomas 
Published: April 2024

AbstractUrbanisation has contributed to a severe decline in biodiversity worldwide. However, urban ecosystems can also play an important role in the conservation of threatened species, including ground-nesting birds such as the Eurasian Oystercatcher (Haematopus ostralegus). While the coastal populations of this shorebird have declined sharply, there is growing evidence that pairs nesting on urban flat roofs have high reproductive success. However, the reasons for rooftop nesting and the species’ habitat use in urban areas remain poorly understood. In this study, we investigate the territory selection and foraging behaviour of the Eurasian Oystercatcher in the city of Münster (NW Germany). All nesting sites were located on flat roofs (N = 24), most of which were covered with gravel. Overall, reproductive success was high. This was mainly because the roofs provided protection from mammalian predators, leading to increased nest and chick survival. Moreover, breeding performance in the study area was favoured by the proximity of sports pitches. According to our observations, they provided a large amount of easily accessible prey throughout the breeding season. Overall, our study highlights that the reproductive success of the Eurasian Oystercatcher in urban environments is highly dependent on both safe nesting sites on flat roofs and the availability of suitable foraging habitats. Although our study suggests that breeding in urban areas can be beneficial for the model organism, the species’ strong territory fidelity makes it very sensitive to the rapid environmental changes occurring in cities. The value of urban ecosystems for bird conservation should therefore be better integrated into urban planning and management.
Non-parametric quantile regression-based modelling of additive effects to solar irradiation in Southern Africa
Authors: Masache Amon , Maposa Daniel , Mdlongwa Precious , Sigauke Caston 
Published: April 2024

AbstractModelling of solar irradiation is paramount to renewable energy management. This warrants the inclusion of additive effects to predict solar irradiation. Modelling of additive effects to solar irradiation can improve the forecasting accuracy of prediction frameworks. To help develop the frameworks, this current study modelled the additive effects using non-parametric quantile regression (QR). The approach applies quantile splines to approximate non-parametric components when finding the best relationships between covariates and the response variable. However, some additive effects are perceived as linear. Thus, the study included the partial linearly additive quantile regression model (PLAQR) in the quest to find how best the additive effects can be modelled. As a result, a comparative investigation on the forecasting performances of the PLAQR, an additive quantile regression (AQR) model and the new quantile generalised additive model (QGAM) using out-of-sample and probabilistic forecasting metric evaluations was done. Forecasted density plots, Murphy diagrams and results from the Diebold–Mariano (DM) hypothesis test were also analysed. The density plot, the curves on the Murphy diagram and most metric scores computed for the QGAM were slightly better than for the PLAQR and AQR models. That is, even though the DM test indicates that the PLAQR and AQR models are less accurate than the QGAM, we could not conclude an outright greater forecasting performance of the QGAM than the PLAQR or AQR models. However, in situations of probabilistic forecasting metric preferences, each model can be prioritised to be applied to the metric where it performed slightly the best. The three models performed differently in different locations, but the location was not a significant factor in their performances. In contrast, forecasting horizon and sample size influenced model performance differently in the three additive models. The performance variations also depended on the metric being evaluated. Therefore, the study has established the best forecasting horizons and sample sizes for the different metrics. It was finally concluded that a 20% forecasting horizon and a minimum sample size of 10000 data points are ideal when modelling additive effects of solar irradiation using non-parametric QR.
An increase in ER stress and unfolded protein response in iPSCs-derived neuronal cells from neuronopathic Gaucher disease patients
Authors: Pornsukjantra Tanapat , Saikachain Nongluk , Sutjarit Nareerat , Khongkrapan Arthaporn , Tubsuwan Alisa , Bhukhai Kanit , Tim-Aroon Thipwimol , Anurathapan Usanarat , Hongeng Suradej , Asavapanumas Nithi 
Published: April 2024

AbstractGaucher disease (GD) is a lysosomal storage disorder caused by a mutation in theGBA1gene, responsible for encoding the enzyme Glucocerebrosidase (GCase). Although neuronal death and neuroinflammation have been observed in the brains of individuals with neuronopathic Gaucher disease (nGD), the exact mechanism underlying neurodegeneration in nGD remains unclear. In this study, we used two induced pluripotent stem cells (iPSCs)-derived neuronal cell lines acquired from two type-3 GD patients (GD3-1 and GD3-2) to investigate the mechanisms underlying nGD by biochemical analyses. These iPSCs-derived neuronal cells from GD3-1 and GD3-2 exhibit an impairment in endoplasmic reticulum (ER) calcium homeostasis and an increase in unfolded protein response markers (BiP and CHOP), indicating the presence of ER stress in nGD. A significant increase in the BAX/BCL-2 ratio and an increase in Annexin V-positive cells demonstrate a notable increase in apoptotic cell death in GD iPSCs-derived neurons, suggesting downstream signaling after an increase in the unfolded protein response. Our study involves the establishment of iPSCs-derived neuronal models for GD and proposes a possible mechanism underlying nGD. This mechanism involves the activation of ER stress and the unfolded protein response, ultimately leading to apoptotic cell death in neurons.
Exploration of lncRNA/circRNA-miRNA-mRNA network in patients with chronic atrophic gastritis in Tibetan plateau areas based on DNBSEQ-G99 RNA sequencing
Authors: Pan Wen , Liu Chao , Ren Tao , Chen Xiaohong , Liang Cuiting , Wang Jin , Yang Jinlin 
Published: April 2024

AbstractA higher incidence of chronic atrophic gastritis (CAG) is generally considered as a precancerous lesion in gastric cancer (GC). The aim of this study was to identify potential molecules involved in the pathogenesis of CAG in the Tibetan plateau, hoping to help the diagnosis and management of the disease. Atrophic and non-atrophic gastric mucosal tissue samples were collected from seven patients with chronic gastritis (CG). Differentially expressed lncRNAs, circRNAs, miRNAs, and mRNAs between CAG and chronic non-atrophic gastritis (CNAG) groups were identified based on DNBSEQ-G99 RNA sequencing. Subsequently, competitive endogenous RNA (ceRNA) regulatory networks (lncRNA/circRNA-miRNA-mRNA networks) were constructed. Two datasets (GSE153224 and GSE163416), involving data from non-Tibetan plateau areas, were used to further screen out Tibetan plateau key mRNAs, followed by the common genes of Tibetan plateau key and ferroptosis-related mRNAs were also identified. Functional enrichment analyses were performed to investigate the biological functions of Tibetan plateau mRNAs in the CAG. A total of seven lncRNA-miRNA-mRNA relationship pairs and 424 circRNA-miRNA-mRNA relationship pairs were identified in this study. The relationship pairs of hsa_circ_0082984-hsa-miR-204-5p-CACNG8, lncRNA DRAIC/has_circ_0008561-hsa-miR-34a-5p-AR/GXYLT2, lncRNA GAS1RR/RGMB-AS1/hsa_circ_0008561-hsa-miR-3614-5p-TMEM216/SUSD5, and LINC00941/hsa_circ_0082984-hsa-miR-873-3p-TMC5 can be involved in the pathogenesis of CAG. Additionally, eight common genes of Tibetan plateau key and ferroptosis-related differentially expressed mRNAs (DEmRNAs) (CBS, SLC2A4, STAT3, ALOX15B, ATF3, IDO1, NOX4, and SOCS1) were identified in CAG. The common genes of Tibetan plateau key and ferroptosis-related DEmRNAs can play a role in the JAK-STAT signaling pathway. This study identified important molecular biomarkers that may be involved in regulating the pathological mechanisms of CAG in the Tibetan plateau, which provides potential research directions for future research.