bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of different root canal irrigants on surface roughness and microhardness of Biodentine combined with triple antibiotic paste: An in vitro study
Authors: Halkai Rahul , Ishaq S. Syed , Halkai Kiran R. , Mahveen Syeda Uzma 
Published: May 2024

Background:
Biodentine is widely used for endodontic applications; recently, it has been incorporated with triple antibiotic paste (TAP). The effect of endodontic irrigants on the physical characteristics of this new combination needs to be studied.

Aims:
The aim of the study was to evaluate the surface roughness and microhardness of Biodentine incorporated with TAP subjected to various endodontic irrigants.

Materials and Methods:
Hundred cylindrical discs (6 mm × 3 mm) were prepared by mixing the Biodentine with TAP (3:1). The specimens were subjected to different irrigating solutions for 5 min in 5 groups (n = 20): Group 1: distilled water (control), Group 2: 2.5% sodium hypochlorite, Group 3: 17% ethylenediaminetetraacetic acid, Group 4: 2% chlorhexidine (CHX), and Group 5: 2% chitosan nanoparticles (CSNs). Half of the specimens in each group were subjected to surface roughness (n = 10) and another half to microhardness (n = 10). Surface roughness was measured using a surface roughness tester, and digital Vickers microhardness testing was performed on each specimen.

Statistical Analysis:
One-way ANOVA and post
hoc Tukey’s tests (P ≤ 0.05) were used.

Results:
The highest microhardness was found with 2% CSN, whereas 2% CSN and 2% CHX had a minimal effect on the surface roughness of Biodentine incorporated with TAP (P ≤ 0.05).

Conclusion:
The root canal irrigant 2% CSN exhibited the highest microhardness and least surface roughness of modified Biodentine with TAP.
Effects of novel additives on the mechanical and Biological properties of glass ionomer cement: An in vitro study
Authors: Piyush Gupta , Kalyan S. Sai , Aparna U. Palekar , Khyati Gupta , Basawaraj Biradar 
Published: May 2024

Aim:
To evaluate the efficacy of incorporated novel additives in Glass Ionomer Cement to ameliorate biocompatibility and mechanical properties.

Introduction:
Though Glass Ionomer Cement (GIC) has multiple advantages, it is not strong enough for medical applications, and its biocompatibility is questionable. To improve biocompatibility and its mechanical properties, a study was performed to investigate the potential benefits of adding graphene, carbon nanotubes, hydroxyapatite, and bioactive glass to GIC. The objective was to enhance both the mechanical properties and biocompatibility of GIC.

Material and Method:
Modified Glass Ionomer Cement was prepared by creating five groups. Hydroxyapatite, multi-walled carbon nanotubes, graphene, and bioactive glass were incorporated in a 10:1 weight ratio, respectively. Group 5 was designated as the control group and used Fuji Type II GIC. After preparing 90 samples, they were kept in deionized water for a day and then evaluated their compressive strength, microhardness, and diametral tensile strength, and also checked their in vitro cytotoxicity by direct contact with L929 mammalian fibroblast cells.

Statistical Analysis:
The data were examined using mean and standard deviation descriptive statistics. The comparative evaluation was done via Tukey HSD test and one-way ANOVA using S.P.S.S. software.

Result:
It showed that Group 3 had better results in compressive strength (144.478+- 3.989), diametral tensile strength (20.29+- 0.8601), and microhardness (131+-3.536) when compared with other groups while in the biocompatibility (viability %) Group 1 [82.55], Group 3 [76.49], Group 4 [87.63], while Group 2[58.02].

Conclusion:
Group 3 has better physical properties in microhardness, diametral tensile strength, and compressive strength, than the other groups. In Biocompatibility, Group 1, Group 3, Group 4, and Group 5 were noncytotoxic at the same time multi-walled carbon nanotubes group (Group 2) had cytotoxic potential.
The advantages and intraoperative management of the laparoscopic approach in perforated appendicitis
Authors: Daduk Yildiray , Seker Ahmet , Sozutek Alper 
Published: May 2024

Abstract

Introduction:
Gangrene/perforated appendicitis entails high rates of morbidity and mortality. The purpose of this study is to discuss the reliability, surgical management and post-operative complications of laparoscopic interventions in the treatment of perforated appendicitis.

Patients and Methods:
One hundred and ten patients (50 men and 60 women) diagnosed with perforated appendicitis based on history, physical examinations, laboratory and computed tomography findings between January 2016 and May 2022 were analysed retrospectively. Preoperative laboratory and radiological findings, surgical methods and post-operative complications were evaluated.

Results:
Abdominal pain defence and rebound were present in all patients. In terms of radiological findings, intra-abdominal free fluid was present in all patients and abscess in 42. Post-operative abdominal surgical site infection developed in six patients. No intra-abdominal abscess or incisional hernia was observed during follow-ups.

Conclusion:
As a diagnostic tool, permitting better visualisation of the abdominal cavity, entailing fewer post-operative complications and obviating the need for large incisions, laparoscopy can represent the approach of choice in the treatment of perforated appendicitis.
Ligamentum teres hepatis incarcerated within linea alba hernia: A case report
Authors: Liao Ke , Shi Lujie 
Published: May 2024

Abstract
Incarcerated linea alba hernia is a rare form of ventral hernia. Most of these contain pre-peritoneal fat or the omentum. Herniation of containing ligamentum teres hepatis is seldom seen. A 52-year-old man presented with an abdominal wall mass and dull pain for 2 weeks. Computed tomography and ultrasound examination of the abdomen revealed an epigastrium linea alba hernia containing the liver round ligament. A hernial sac of size 3 cm × 4 cm was explored by laparoscopic surgery and successfully managed with hernia repair.
Telescopic dissection versus balloon dissection during laparoscopic totally extraperitoneal inguinal hernia repair: A prospective randomised control trial
Authors: Varun Rajanna , Shaikh Oseen Hajilal , Sagar Prakash , Vijayakumar Chellappa , Balasubramanian Gopal , Kumbhar Uday Shamrao 
Published: May 2024

Abstract

Background:
Totally extraperitoneal (TEP) repair involves creating a preperitoneal space. The preperitoneal space can be created by balloon or telescopic dissection (TD). Nevertheless, these techniques may have some complications. However, there are very few studies that compare these two techniques. This study aims to assess the impact and comprehensively compare the TD and balloon dissection (BD) methods in patients undergoing laparoscopic TEP inguinal hernia repair.

Patients and Methods:
This was a single-centre, double-blinded, prospective, randomised, controlled trial comparing BD and TD for the creation of the preperitoneal space. The primary end point was to compare the post-operative pain score, intraoperative complications and surgical site occurrence between the two groups. The secondary end point was to assess the impact of the dissection technique on operative time for the creation of extraperitoneal space during laparoscopic TEP inguinal hernia repair.

Results:
A total of 46 patients were included in the study (23 in each group). Baseline parameters were comparable between the groups. The total operative time between the groups (120 min vs. 160 min; P < 0.005) was statistically significant. The incidence of the peritoneal breach was statistically less in the BD group (43% vs. 13%; P < 0.005). Other short-term and long-term complications were less in the BD group but not statistically significant.

Conclusions:
BD in TEP inguinal hernia repair reduces the operative time and peritoneal breach. When compared to TD in terms of operative time, routine use of BD can be proposed. It will be beneficial in the early part of the learning curve.
Laparoscopic segmental colectomy for a rare case of extraluminal amoeboma masquerading as stromal tumour of the colon
Authors: Shenoy K. Ganesh , Thomas Marina , Jeur Amol S. , Ramesh B. S. , Jan Nawab 
Published: May 2024

Abstract

Entamoeba histolytica is known to cause infectious colitis that presents with diarrhoea or dysentery. Extra intestinal manifestations result in amoebic abscesses to involve organs such as the liver, lungs or brain. Very rarely, it may present like a pseudotumour due to a mass formation if the primary infection was untreated or inadequately treated. We, herein, report a rare case of extraluminal amoebic pseudotumour in a young female with a diagnosis of a gastrointestinal stromal tumour of hepatic flexure of the transverse colon on pre-operative imaging and per operative findings, but final histopathological examination of the resected specimen proved it to be an amoeboma. The rarity of this case was the extraluminal presentation, unlike other reported cases of intraluminal pseudotumour. After an extensive literature search, we believe that this is the first reported case of extraluminal pseudotumour of the transverse colon managed by laparoscopic segmental colectomy.
Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease
Authors: Kawasaki Eiji , Tamai Hidekazu , Fukuyama Takahiro , Sagara Yoko , Hidaka Ryutaro , Uchida Aira , Tojikubo Masayuki , Tatsumoto Narihito , Akehi Yuko , Hiromatsu Yuji 
Published: May 2024

BACKGROUND
In recent years, the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes (T1D). While it has been established that 20%-30% of T1D patients suffer from autoimmune thyroid disease (AITD), there is limited available data regarding the presence of anti-islet autoantibodies in AITD patients. Among commercially available anti-islet autoantibodies, glutamic acid decarboxylase 65 autoantibodies (GADAs) are often the first marker measured in general clinical practice.
AIM
To investigate the frequency of anti-islet autoantibodies in AITD patients.
METHODS
Our study involved four hundred ninety-five AITD patients, categorized into three distinct groups: AITD with T1D (n = 18), AITD with phenotypic type 2 diabetes (T2D) (n = 81), and AITD without diabetes (n = 396), and the enzyme-linked immunosorbent assay (ELISA) was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody (3 Screen ICA), GADA, insulinoma-associated antigen-2 autoantibodies (IA-2As), and zinc transporter 8 autoantibodies (ZnT8As) within these groups.
RESULTS
The frequency of 3 Screen ICA in AITD patients with T1D, T2D, and those without diabetes were 88.9%, 6.2%, and 5.1%, respectively, with no significant difference seen between the latter two groups. Notably, the frequency of 3 Screen ICA was 11.1% higher in AITD patients with T1D, 1.3% higher in AITD patients with T2D, and 1.1% higher in AITD patients without diabetes compared to GADA, respectively. Furthermore, 12.5%, 20.0%, and 20.0% of the 3 Screen ICA-positive patients were negative for GADA. Additionally, 1.3% of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual autoantibodies. Among the 3 Screen ICA-positive patients, there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D compared to those without diabetes (37.5% vs 5.0%, P < 0.05). However, this proportion was similar to that in AITD patients with T2D (20.0%). Nevertheless, there was no significant difference in 3 Screen ICA titers between AITD patients with T1D and those without diabetes (436.8 ± 66.4 vs 308.1 ± 66.4 index). Additionally, no significant difference in 3 Screen ICA titers was observed between Graves’ disease and Hashimoto’s thyroiditis in any of the groups.
CONCLUSION
Our findings reveal that some AITD patients without diabetes exhibit 3 Screen ICA titers comparable to those in AITD patients with T1D. Thus, 3 Screen ICA outperforms GADA in identifying latent anti-islet autoantibody-positive individuals among AITD patients.
Systematic investigation of Radix Salviae for treating diabetic peripheral neuropathy disease based on network Pharmacology
Authors: Kang Tao , Qin Xiao , Chen Yan , Yang Qian 
Published: May 2024

BACKGROUND
Diabetic peripheral neuropathy (DPN) is a debilitating complication of diabetes mellitus with limited available treatment options. Radix Salviae , a traditional Chinese herb, has shown promise in treating DPN, but its therapeutic mech-anisms have not been systematically investigated.
AIM
Radix Salviae (Danshen in pinin), a traditional Chinese medicine (TCM), is widely used to treat DPN in China. However, the mechanism through which Radix Salviae treats DPN remains unclear. Therefore, we aimed to explore the mechanism of action of Radix Salviae against DPN using network pharmacology.
METHODS
The active ingredients and target genes of Radix Salviae were screened using the TCM pharmacology database and analysis platform. The genes associated with DPN were obtained from the Gene Cards and OMIM databases, a drug-com-position-target-disease network was constructed, and a protein–protein inter-action network was subsequently constructed to screen the main targets. Gene Ontology (GO) functional annotation and pathway enrichment analysis were performed via the Kyoto Encyclopedia of Genes and Genomes (KEGG) using Bioconductor.
RESULTS
A total of 56 effective components, 108 targets and 4581 DPN-related target genes of Radix Salviae were screened. Intervention with Radix Salviae for DPN mainly involved 81 target genes. The top 30 major targets were selected for enrichment analysis of GO and KEGG pathways.
CONCLUSION
These results suggested that Radix Salviae could treat DPN by regulating the AGE-RAGE signaling pathway and the PI3K-Akt signaling pathway. Therefore, Danshen may affect DPN by regulating inflammation and apoptosis.
Estrogen restores disordered lipid metabolism in visceral fat of prediabetic mice
Authors: Liu Su-Huan , Shangguan Zhao-Shui , Maitiaximu Paiziliya , Li Zhi-Peng , Chen Xin-Xin , Li Can-Dong 
Published: May 2024

BACKGROUND
Visceral obesity is increasingly prevalent among adolescents and young adults and is commonly recognized as a risk factor for type 2 diabetes. Estrogen [17β-estradiol (E2)] is known to offer protection against obesity via diverse me-chanisms, while its specific effects on visceral adipose tissue (VAT) remain to be fully elucidated.
AIM
To investigate the impact of E2 on the gene expression profile within VAT of a mouse model of prediabetes.
METHODS
Metabolic parameters were collected, encompassing body weight, weights of visceral and subcutaneous adipose tissues (VAT and SAT), random blood glucose levels, glucose tolerance, insulin tolerance, and overall body composition. The gene expression profiles of VAT were quantified utilizing the Whole Mouse Genome Oligo Microarray and subsequently analyzed through Agilent Feature Extraction software. Functional and pathway analyses were conducted employing Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses, respectively.
RESULTS
Feeding a high-fat diet (HFD) moderately increased the weights of both VAT and SAT, but this increase was mitigated by the protective effect of endogenous E2. Conversely, ovariectomy (OVX) led to a significant increase in VAT weight and the VAT/SAT weight ratio, and this increase was also reversed with E2 treatment. Notably, OVX diminished the expression of genes involved in lipid metabolism compared to HFD feeding alone, signaling a widespread reduction in lipid metabolic activity, which was completely counteracted by E2 administration. This study provides a comprehensive insight into E2's local and direct protective effects against visceral adiposity in VAT at the gene level.
CONCLUSION
In conclusion, the present study demonstrated that the HFD-induced over-nutritional challenge disrupted the gene expression profile of visceral fat, leading to a universally decreased lipid metabolic status in E2 deficient mice. E2 treatment effectively reversed this condition, shedding light on the mechanistic role and therapeutic potential of E2 in combating visceral obesity.
Model for assessing the influence of quality of life indicators on the breast cancer incidence
Authors: Ermolitskaya Marina Z. , Kiku Pavel F. , Abakumov Aleksandr I. 
Published: May 2024

Introduction. Malignant neoplasms of the breast are the leading oncological pathology among the female population of the Primorsky region. Identification of the relationship between the incidence rate and quality of life indicators, along with modern diagnostic methods, makes it possible to improve preventive measures to reduce the prevalence in the population at the regional level.
Purpose. Development of a regression model that describes the impact of socio-economic indicators of quality of life on the incidence of breast cancer in the population of the Primorsky region.
Materials and methods. The initial data sample consisted of seventeen indicators of the quality of life in the population of Primorsky region for the period from 1994 to 2020. To reduce the dimensionality of the data, the principal component method was used, and regression analysis was used to build the model. The quality of the constructed model was checked on the base of the calculation of the coefficient of determination, the standard error, and the approximation error.
Results. There were identified 15 indicators of the quality of life in the population that significantly affect the pathology of breast cancer in the Primorsky region. Principal component analysis has made it possible to group the quality of life indicators into three major compartments. The first component explains 80.8% of the variance, the second — 10%, the third — 4%. The first compartment included indicators characterizing the socio-economic aspects of the life of the population, the second — medical and social, and the third — statistical indicators of inequality in monetary incomes of the population, characterizing the social differentiation of society. A regression model has been developed on the principal compartments.
Research limitations. The research materials are limited to the results of statistical analysis of 17 indicators of the quality of life of the population of the Primorsky region for the period from 1994 to 2020 and the application of the developed regression model at the regional level.
Conclusion. The results of this study made it possible to identify the relationship between the incidence of breast cancer and risk factors and develop a predictive model, which can be useful in planning preventive measures to improve the quality of life and reduce the incidence at the regional level.
Optimization of Methods for Forecasting the Number of Road Accidents
Authors: Gorzelańczyk Piotr , Tylicki Henryk 
Published: May 2024

Due to the abrupt rise in the number of vehicles on the road, there is an increasing risk of traffic accidents, which can result in fatalities and damage to economic resources. This is due to the rapid growth in the human population and the development in motorization. The biggest issue with anticipating and analyzing data on road accidents is the small quantity of the dataset that may be used for study in this area. Road accidents have a low geographical and temporal density, despite the fact that they cause millions of deaths and injuries annually.The purpose of this article is to suggest a strategy for improving methodologies for determining how frequently traffic accidents occur in Poland. Techniques for multi-criteria optimization were used in this. We can infer from the findings that the suggested method can be utilized to determine the best methods for forecasting the frequency of traffic accidents. The method used can successfully be used to forecast other events not only logistics or transportation.

Received: 21 November 2023 | Revised: 11 March 2024 | Accepted: 9 April 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
Data available on request from the corresponding author upon reasonable request.

Author Contribution Statement
Piotr Gorzelańczyk: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing - original draft, Writing - review & editing, Visualization, Supervision, Project administration; Henryk Tylicki: Conceptualization, Methodology, Formal analysis, Project administration.
THỰC TRẠNG KIẾN THỨC CỦA BÀ MẸ VỀ PHÒNG BỆNH CHO TRẺ DƯỚI 5 TUỔI MẮC TIÊU CHẢY ĐIỀU TRỊ TẠI BỆNH VIỆN VINMEC HẠ LONG NĂM 2022
Authors: Vũ Thu Hiền , Nguyễn Lệ Quyên 
Published: May 2024

Mục tiêu: Mô tả thực trạng kiến thức của bà mẹ về phòng bệnh cho trẻ dưới 5 tuổi mắc tiêu chảy điều trị tại khoa Nhi, Bệnh viện Vinmec Hạ Long năm 2022 và đề xuất một số giải pháp nâng cao kiến thức về phòng bệnh tiêu chảy cho trẻ dưới 5 tuổi. Đối tượng và phương pháp nghiên cứu: 62 bà mẹ có con dưới 5 tuổi mắc tiêu chảy đang điều trị tại Khoa Nhi, Bệnh viện Vinmec Hạ Long trong thời gian từ tháng 5 đến tháng 7 năm 2022. Nghiên cứu mô tả cắt ngang. Kết quả: Bà mẹ có kiến thức đúng về thời điểm cho trẻ ăn bổ sung và thời điểm cai sữa chiếm tỷ lệ thấp với 38,3% và 41,9%. Tỷ lệ bà mẹ trả lời đúng kiến thức về rửa tay bằng xà phòng bệnh tiêu chảy tương đối cao với 74,1%. Kết luận: Kiến thức phòng bệnh của bà mẹ về phòng bệnh tiêu chảy cho trẻ ở mức kém và trung bình chiếm tỷ lệ cao (16,1% và 45,2%), đạt mức tốt còn thấp với tỷ lệ 38,7%.
ĐẶC ĐIỂM LÂM SÀNG CỦA BỆNH NHÂN HEN PHẾ QUẢN TẠI PHÒNG KHÁM KHOA NỘI 1 BỆNH VIỆN SAINT PAUL THÁNG 11-12 NĂM 2020
Authors: Lê Văn Thêm , Phạm Thị Cẩm Hưng 
Published: May 2024

Mục tiêu: Mô tả đặc điểm lâm sàng của bệnh nhân hen phế quản tại phòng khám khoa Nội 1 bệnh viện Sain Paul tháng 11-12 năm 2020 Phương pháp: Mô tả cắt ngang Kết quả nghiên cứu: Đa số người bệnh hen phế quản có độ tuổi trên 70 (40%), là nam giới (58%), trong gia đình có người bị hen (70%), không có tiền sử dị ứng (62%), không mắc bệnh hen từ nhỏ (76%). Đa số người bệnh có ho đờm trong (60%), xuất hiện cơn khó thở cả về đêm và khi thay đổi thời tiết (86%), nặng ngực nhiều lần chiếm 68%. Đa số người bệnh có tần số mạch trong giới hạn bình thường (92%), không sốt (100%), tần số thở trong giới hạn bình thường (96%). Đa số người bệnh không có co kéo cơ hô hấp phụ (98%), nghe phổi không có rale (92%), không có rale rít (98%). Kết luận: Đa số bệnh nhân hen phế quản ngoài cơn hen có các triệu chứng toàn thân và thực thể bình thường
ADOÇÃO INTUITO PERSONAE: IMPREVISÃO LEGAL E O DECLÍNIO A LUZ DOS DIREITOS E GARANTIAS DO MENOR
Authors: Silva Lucidalva Gomes da , Disconzi Veronica Silva do Prado , Silva Lucidalva Gomes da 
Published: May 2024

Esse artigo buscou discutir a entrada em vigor da Lei nº 12.010/ 2009, e com esta a limitação da possibilidade da adoção intuito personae, tornando a mesma proibida pelo ordenamento jurídico brasileiro e dificultando o interesse das famílias adotantes que almeja adotar aquela criança ou adolescentes em específico. A pesquisa tem como objetivo descrever os fatores internos e externos que dificultam a verdadeira função social da adoção, em específico a adoção intuito personae. Dessa forma, a pesquisa tem por objetivo geral de forma exploratória e descritiva, pesquisar e analisar as colisões na legislação brasileira e dos princípios fundamentais, diante do assunto e, as severas consequências da atual forma de posicionamento do ordenamento jurídico brasileiro. Diante do exposto, o presente estudo pretende, no decorrer dessa pesquisa, esclarecer pontos que merecem atenção redobrada para que de fato seja assegurado o melhor interesse da criança e do adolescente, que é a sua proteção de forma integral.