bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of non-surgical periodontal treatment plus zinc and magnesium supplementation on oxidative stress and antioxidants enzymes in type 2 diabetes patients: A quasi-experimental study
Authors: Alarcón-Moreno José Carlos , Flores-Muñoz Mónica , Blázquez-Morales María Sobeida L. , García-Rivera Miguel Eric , Rodríguez-Alba Juan Carlos , Castro-López Claudio Rafael , Nachón-García Francisco Javier , Muñoz-Muñoz Víctor Hugo , Nachón-García María Gabriela 
Published: June 2024

Abstract

Background
Periodontal disease associated with T2DM is a chronic condition that affects the oral cavity of people living with T2DM. The mechanisms of the interaction between T2DM and PD are complex and involve multiple pathophysiological pathways related to the systemic inflammatory process and oxidative stress. Non-surgical periodontal treatment is considered the standard for the management of this disease; however, patients with systemic conditions such as T2DM do not seem to respond adequately. For this reason, the use of complementary treatments has been suggested to support non-surgical periodontal treatment (NSPT) to reduce the clinical consequences of the disease and improve the systemic conditions of the patient. The use of zinc gluconate and magnesium oxide as an adjunct to NSPT and its effects on periodontal clinical features and oxidative stress in patients with PD-T2DM is poorly understood.
Methods
A quasi-experimental study was performed in patients with periodontal diseases associated with T2DM. 45 subjects were assigned to a control group [non-surgical periodontal treatment (NSPT)] or experimental group (NSPT + 500 mg of magnesium oxide and 50 mg of zinc gluconate for oral supplementation for 30 days). Sociodemographic characteristics, physiological factors, biochemical parameters, and clinical features of periodontal diseases were assessed.
Results
In this research, the use of zinc and magnesium is suggested as a complement to non-surgical periodontal treatment. A change in periodontal clinical characteristics was observed, which has been associated with disease remission. Additionally, a shift in MDA levels was presented for both groups. Furthermore, the supplementation group showed an increase in antioxidant enzymes when compared to the group that only received NSPT.
Conclusion
zinc gluconate and magnesium oxide can serve as a complementary treatment to NSPT, that supports the remission of PD. As a result of regulation-reduction of oxidative biomarkers and increase in antioxidant enzymes activity. ISRCTN 14092381. September 13º 2023. Retrospective Registration
Trial Registration
https://www.isrctn.com.
Effects of post-aquatic exercise hypotension in older adults: a systematic review with meta-analysis
Authors: Sisconeto Tássia Magnabosco , Mariano Igor Moraes , Garcês Caroline Pereira , Miranda Camila , Zanella Jonas Casagranda , Kanitz Ana Carolina , Puga Guilherme Morais 
Published: June 2024

Abstract

The effects of aquatic exercise on acute blood pressure (BP) responses in older population remain inconsistent. The objective was to review the literature on the effects of aquatic exercises performed in a vertical position on acute BP responses after exercise in the older adults. We conducted a systematic review and meta-analysis of clinical trials, published until August 2023, using digital databases (EMBASE, PUBMED, Lilacs, SPORTDiscus, and Web of Science). Eight studies with 197 individuals were included for qualitative analysis, and seven studies were included in the meta-analysis. The aquatic exercise reduced systolic blood pressure (SBP) by -6.86 mmHg within 1 hour and by -4.14 mmHg for 24 hours post-exercise. However, it did not affect diastolic blood pressure (DBP) responses. Furthermore, subgroup analysis showed that HIIE reduced SBP by -15.50 mmHg and DBP by -5.97 mmHg after the sessions. Already the moderate-intensity continuous exercise reduced SBP by -4.91 mmHg, with no effect on DBP up to 1 hour after the sessions. Subgroup analysis over 24 hours was not possible. Acute aquatic exercise can reduce BP in the older adults, especially SBP. Post-exercise BP reduction is of utmost importance for the older people in preventing cardiovascular diseases, such as arterial hypertension.
Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression
Authors: Fabregat Isabel , Amengual Josep , Vaquero Javier , González-Sánchez Ester , Alay Ania , Bertran Esther , Sánchez Aránzazu , Herrera Blanca , Meyer Kathleen , Maus Mate , Serrano Manuel , Martínez-Chantar María 
Published: June 2024

Abstract

Iron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have deepened into the role of iron and senescence in an experimental model of chronic liver injury, analyzing whether an iron chelator would prevent liver fibrosis by decreasing hepatocyte senescence. The model of carbon tetrachloride (CCl4) in mice was used as experimental model of liver fibrosis. Results demonstrated that during the progression of liver fibrosis, accumulation of iron occurs, concomitant with the appearance of fibrotic areas and senescent cells surrounding these areas. Isolated parenchymal hepatocytes from CCl4-treated mice show a gene transcriptomic signature compatible with iron accumulation and senescence, which correlate with induction of Reactive Oxygen Species (ROS)-related genes and activation of the Transforming Growth Factor-beta (TGF-β) pathway. Analysis of the iron-related gene signature in a published single-cell RNA-seq dataset from CCl4-treated livers indicated iron accumulation also in other non-parenchymal liver cells, correlating with senescence in some of them. Treatment with deferiprone, an iron chelator, attenuated the accumulation of iron, fibrosis and senescence, concomitant with relevant changes in the senescent-associated secretome (SASP), which switched towards a more anti-inflammatory profile of cytokines. In vitro experiments in human hepatocyte HH4 cells demonstrated that iron accumulates in response to a senescence inducing reagent, doxorubicin, being deferiprone able to prevent senescence and SASP, attenuating growth arrest and cell death. However, deferiprone did not significantly affect senescence or activation markers in human hepatic stellate LX-2 cells. Transcriptomic data in patients demonstrated the relevance of iron accumulation in the progression of liver fibrosis, correlating with a SASP-related gene signature and pivotal hallmarks of hepatocyte damage. Altogether, our study establishes iron accumulation as a clinically exploitable driver to attenuate pathological senescence in hepatocytes.
Risk of Blood Clots After COVID-19 Vaccination and Infection: A Risk-Benefit Analysis
Authors: Zhao Lili , Tran Huong , Risk Malcolm , Nair Girish 
Published: June 2024

Abstract

We analyzed the risk-benefit of COVID-19 vaccine using a causal model to explain and weigh up possible risk factors of blood clots after vaccination. A self-controlled case series method was used to examine the association between blood clots and COVID-19 vaccination. To avoid bias due to the under-reported infection among non-hospitalized subjects, a case-control study was used to compare the risk of blood clots in infected subjects to control subjects who were hospitalized due to physical injury. We found increased risks of blood clots after vaccination (incidence rate ratio is 1.13, 95% CI: [1.03,1.24] after the first dose and 1.23, 95% CI: [1.13,1.34] after the second dose). Furthermore, vaccination attenuated the increased risk of blood clots associated with infection (odds ratio is 2.16, 95% CI: [1.93,2.42] in unvaccinated versus 1.46, 95% CI: [1.25,1.70] in vaccinated). After accounting for vaccine efficacy against infection and the protection against infection-associated blood clots, receiving the COVID-19 vaccines decreases the risk of blood clots, especially during high infection rate period.
Climate Trauma from Wildfire Exposure Impacts Cognitive Decision-Making
Authors: Nan Jason , Jaiswal Satish , Ramanathan Dhakshin , Withers Mathew , Mishra Jyoti 
Published: June 2024

Abstract

Climate trauma refers to the mental health sequalae of climate disaster events. We have previously shown evidence for climate trauma with high prevalence of trauma, anxiety and depression symptoms after California’s 2018 Camp Fire wildfire. Here, we investigate whether this climate trauma impacts cognitive decision-making and its neural correlates. One year after the wildfire, we recruited three groups - those directly exposed (n = 27), indirectly exposed (who community members who witnessed the wildfire n = 21), versus non-exposed controls from a nearby region (n = 27). Participants performed a decision-making task that led to immediate and cumulative point rewards on each trial with simultaneous electroencephalography (EEG) recordings. We evaluated Win-Stay behavior in choosing to stay with the greater expected value option. Directly-exposed individuals showed significantly reduced Win-Stay behavior relative to the other groups. EEG analyses showed significantly greater parietal alpha activity for the selected choice and ensuing rewards in the directly-exposed individuals, with underlying cortical source in posterior cingulate cortex. Overall, these findings suggest that climate trauma may significantly impact neuro-cognitive processing in the context of value-based decision-making, and may serve as a useful biomarker target for future mental health interventions in climate change impacted communities.
Single-Sheath Inverse Technique via Vertical Puncture in Hemodialysis Arteriovenous Fistula Angioplasty
Authors: Hasegawa Tetsuya , Tsuboi Masahiro , Takahashi Yuki , Endo Akira , Gotoh Yasuo 
Published: June 2024

Abstract

Background: Transvenous percutaneous transluminal angioplasty for dialysis access stenosis is sometimes for both the upstream and downstream side of the approach site. A single sheath inversion has been used in some cases, but there are few reports in the literature. The purpose of this study was to retrospectively evaluate the feasibility of the sheath inverse technique using the vertical puncture approach in PTA for stenosis of arteriovenous fistulas for hemodialysis.
Materials and Methods: Twenty patients (26 cases; 13 males; median age, 74 [range: 50–89] years) who underwent percutaneous transluminal angioplasty using the sheath inverse technique for native arteriovenous fistula stenosis between April 2019 and June 2023 were included. A 4-cm sheath (4Fr, 4 cases; 5Fr, 19 cases; 6Fr, 3 cases) was inserted by vertical puncture through a cutaneous vein in the forearm (20 cases) or upper arm (6 cases). After treating one side of the lesion, the sheath was reversed to treat the lesion on the opposite side. The vessel diameter at the sheath insertion site, the success rate of sheath inversion, the number of percutaneous transluminal angioplasty balloon catheters used, the percutaneous transluminal angioplasty success rate, and adverse events were evaluated.
Results: The median diameter at the sheath indwelling site was 5.2 (range: 3.6–9.5) mm, and sheath inversion was successful in all cases. The number of balloon catheters used was oneand two in 17 (65%) and eight cases (31%), respectively, and three in one case wherein a drug-coated balloon was used. Major complications were not observed. However, in one case wherein a sheath had to be placed at the arterial needle puncture site, the skin was hard, leading to difficulty in inversion, and transient venous spasm occurred post-inversion.
Conclusion: The single-sheath inverse technique for arteriovenous fistulas was feasible without sheath withdrawal.
Comparison of Torque between Different Diameters of Copper Rotor bar slot by Using FEM Software
Authors: tian zhuo 
Published: June 2024

Abstract

This paper presents the comparison of different rotor slot diameter which is designed by using FEM software.The parameter is than taken from 0.5HP AC induction motor with a 10 rotor slot by means of hardware experiment.The Parameter is used as the input for FEM for simulation purposes.The 0.5HP three phase induction motor is investigated by the differences of starting torque.This is because the design with smaller rotor slot can produce high starting torque and this is essential for high-inertia loads such as flywheel-equipped punch press,elevators and hoist as required by NEMA design D.Simulation analysis shows that the 4mm diameter of rotor slots have higher starting torque than the rest of the rotor slots which is 3.4NM.
Voltage Abnormity Prediction method of lithium ion Energy Storage power station using Informer Based on Bayesian Optimization
Authors: Rao Zhibo , Wu Jiahui , Li Guodong , Wang Haiyun 
Published: June 2024

Abstract

Due to the flourishing development in the field of energy storage power station, there has been considerable attention directed towards the prediction of battery system states and faults. Voltage, as a primary indicative parameter for various battery faults, holds paramount importance in accurately forecasting voltage abnormity to ensure the safe operation of battery systems. In this study, a prediction method based on the Informer is employed. The Bayesian optimization algorithm is utilized to fine-tune the hyperparameters of the neural network model, thereby enhancing the accuracy of voltage abnormity prediction in energy storage batteries. With a sampling time interval of 1 minute and a one-step prediction, where the training set constitutes 70% of the total data, this approach reduces the root mean square error, mean square error, and mean absolute error of the prediction results to 9.18 mV, 0.0831mV, and 6.708 mV, respectively. The impact of actual grid operation data on the prediction results at different sampling intervals and data training set ratios is also analysed, resulting in a dataset that balances efficiency and accuracy. The proposed Bayesian optimisation-based method can achieve more accurate voltage anomaly prediction.
Fibration symmetry-breaking supports functional transitions in a brain network engaged in language
Authors: Makse Hernan , Gili Tommaso , Avila Bryant , Pasquini Luca , Holodny Andrei , Phillips David , Boldi Paolo , Gabrielli Andrea , Caldarelli Guido , Zimmer Manuel 
Published: June 2024

Abstract

In his book 'A Beautiful Question' [1], physicist Frank Wilczek argues that symmetry is 'nature's deep design,' governing the behavior of the universe, from the smallest
particles to the largest structures [1-4]. While symmetry is a cornerstone of physics, it has not yet been found widespread applicability to describe biological systems [5], particularly the human brain. In this context, we study the human brain network engaged in language and explore the relationship between the structural connectivity
(connectome or structural network) and the emergent synchronization of the mesoscopic regions of interest (functional network). We explain this relationship through a different kind of symmetry than physical symmetry, derived from the categorical notion of Grothendieck fibrations [6]. This introduces a new understanding of the human brain by proposing a local symmetry theory of the connectome, which accounts for how the structure of the brain's network determines its coherent activity. Among the allowed patterns of structural connectivity, synchronization elicits different symmetry subsets according to the functional engagement of the brain. We show that the resting state is a particular realization of the cerebral synchronization pattern characterized by a fibration symmetry that is
broken [7] in the transition from rest to language. Our findings suggest that the brain's network symmetry at the local level determines its coherent function, and we can understand this relationship from theoretical principles.
Single center analysis of cardiac amyloidosis using 99mTc-HMDP imaging for diagnosis and evaluation after tafamidis treatment
Authors: Egi Ryuta , Matsusaka Yohji , Watanabe Kaho , Seto Akira , Matsunari Ichiro , Arai Takahide , Nakano Shintaro , Kuji Ichiei 
Published: June 2024

Abstract

Background The aims of this study were to evaluate the diagnostic performance of 99mTc-HMDP imaging for cardiac amyloidosis and to demonstrate changes in cardiac uptake of 99mTc-HMDP after tafamidis treatment. Seventy-five patients with suspected for cardiac amyloidosis who underwent 99mTc-HMDP imaging were included. We compared clinical data between visually positive and negative groups. We also compared visual Perugini grades and semi-quantitative H/CL (heart-to-contralateral area) ratios and myocardial SUVmax (maximum standardized uptake value) between cardiac transthyretin amyloidosis (ATTR) and amyloid light-chain amyloidosis (AL). Furthermore, H/CL ratio of 99mTc-HMDP and myocardial SUVmax were compared before and after tafamidis administration for cardiac wild-type ATTR.
Results Among 75 patients, 20 patients (26.7%) were visually positive based on Perugini grade. Fifteen patients and 3 patients were pathologically identified as cardiac ATTR and AL, respectively. ATTR group (n =15) had significantly higher H/CL ratios of 99mTc-HMDP than AL group (n = 3) (P = 0.003). ATTR group (n =15) had significantly higher myocardial SUVmax of 99mTc-HMDP than AL group (n = 2) (P = 0.015). After tafamidis treatment for cardiac wild-type ATTR, three of the eight patients (37.5%) had more than 15% decrease in H/CL ratios and five of the eight patients (62.5%) had more than 15% decrease in myocardial SUVmax.
Conclusions H/CL ratio on planar images and SUVmax on SPECT images in 99mTc-HMDP imaging are useful for diagnosing cardiac ATTR. Myocardial SUVmax might be useful for monitoring changes in cardiac uptake after tafamidis treatment for cardiac ATTR.
Successful occluder removal and reocclusion of an atrial septal defect after occluder detachment: A case report
Authors: Zhang Zaiqiang , Ding Jiawang 
Published: June 2024

Abstract

Background: Atrial septal defect (ASD) is a common congenital heart disease, and currently, transcatheter intervention is the most common clinical treatment method. However, certain complications still occur during the surgical process, among which occluder loss and displacement is a rare but serious complication. Although the probability of occluder loss and displacement is low, severe cases can endanger life.
Case presentation: Here, we report the case of a patient who underwent ASD closure in which the occluder fell off into the aortic arch, the detached occluder was recovered through catheter intervention, and the patient underwent ASD closure again.
Conclusions: In this case report, we highlight that although percutaneous closure of an ASD is regarded as a routine procedure, clinicians should remember the possibility of complications, especially occluder loss and displacement. Therefore, surgeons should carefully evaluate the situation before intervention closure, establish standardized intraoperative procedures, and provide timely postoperative follow-up.
Psychological Resilience Mediates Sense of Professional Mission and Career Success in Chinese Intensive Care Unit Nurses: a Cross-sectional Study
Authors: zhang lating , Jiang Xue , Liang Xinhui , Cheng Na , Han Lin , Jia Yao , Wang Ruahua , Fan Haiyan , Wu Wei 
Published: June 2024

Abstract

Background
The nursing industry's stability and progress are adversely affected by the high attrition rate and shortage of nurses; therefore, it is critical to investigate the variables that influence the professional stability of nurses.The sense of professional mission and career success have positive significance for reducing nurses' job burnout. The purpose of this study is to explore the potential mediating role of resilience in this relationship.
Methods
Self-reported questionnaires were utilized by 335 intensive care unit (ICU) nurses to assess their sense of professional mission, psychological resilience, and career success in this cross-sectional study. A structural equation model was developed to validate the indirect relationship between the variables.
Results
There is a correlation among professional mission, psychological resilience and career success. Significant mediating effect of resilience exists between career success and career mission.
Conclusions
In this study, resilience plays an intermediary role between career mission and career success, which provides support for further understanding the mechanism between career mission and career success and bolstering the case for devising comprehensive intervention strategies for resilience. Nursing managers should focus on nurses' sense of professional mission and psychological resilience, and implement strategies to enhance nurses' psychological resilience in order to boost their career success.
Identification and validation of the shared signature gene MMP9 and ANGPTL4 and its regulatory mechanisms in Type 2 Diabetes combined with Osteoarthritis
Authors: Mao Guangming , Xu Wenhao , Wan Lingli , Wang Hongpin , Xu Shutao , Zhang Liangming , Li Shiyang , Liu Peigen , Lai Zhongming , Lan Yuping , Liu Jianhui 
Published: June 2024

Abstract

Objective
Type 2 Diabetes Mellitus (T2D) and Osteoarthritis (OA) are prevalent diseases significantly impacting patients' quality of life. Increasing evidence suggests a correlation between T2D and OA, yet their molecular mechanisms remain elusive. Our study aims to investigate shared biomarkers and potential molecular mechanisms underlying these diseases.
Methods
Gene expression profiles for T2D and OA were sourced from the Gene Expression Omnibus (GEO) database.We employed bioinformatics to identify differentially expressed genes (DEGs) common to T2D and OA. Subsequently, functional annotation, and protein-protein interaction (PPI) analyses were conducted on these DEGs, leading to the preliminary identification of hub genes. Further validation of these hub genes' mRNA expression was achieved using external T2D and OA datasets, culminating in identifying pivotal genes. Western blotting and qRT-PCR techniques validated the expression of these key genes in clinical case samples. The accuracy of the key genes as predictive biomarkers for T2D and OA were assessed using the receiver operating characteristic curve (ROC). We developed a network of interactions between transcription factors (TFs) and microRNAs (miRNAs) .Finally, we identified the most promising therapeutic agents through molecular docking.
Results
We identified 209 shared DEGs between T2D and OA. Functional analysis revealed that these DEGs were predominantly associated with ossification, regulation of leukocyte migration, extracellular matrix (ECM) structural constituent, PI3K/AKT and Wnt signaling pathways. PPI analysis and external datasets validation highlighted MMP9 and ANGPTL4 as pivotal genes in T2D and OA. ANGPTL4 regulates glucose metabolism, osteoclast-mediated bone resorption, cartilage degradation, whereas MMP9 plays a role in ECM degradation and inflammatory responses. Both qRT-PCR and Western blot analyses confirmed high expression levels of pivotal genes in T2D, OA, T2D combined with OA cases.Analysis of TFs-miRNAs interactions identified 7 TFs and one miRNA that collectively regulate pivotal genes. ROC analysis underscored the strong diagnostic potential of MMP9 and ANGPTL4. Raloxifene, Ezetimibe, and S-3304 were also identified as promising therapeutic agents for patients with T2D and OA.
Conclusion
This study uncovers shared signaling pathways, biomarkers, potential therapeutics, and diagnostic models for T2D and OA. These findings offer novel perspectives on the pathogenesis, diagnosis, and treatment of T2D when co-occurring with OA.