bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the role of copper metabolism and STEAP2 in idiopathic pulmonary fibrosis molecular landscape
Authors: Wang Yajun , Chen Shuyang , Chen Shujing , Jiang Jinjun 
Published: June 2024

AbstractIdiopathic pulmonary fibrosis (IPF) is a debilitating interstitial lung disease characterized by progressive fibrosis and poor prognosis. Despite advancements in treatment, the pathophysiological mechanisms of IPF remain elusive. Herein, we conducted an integrated bioinformatics analysis combining clinical data and carried out experimental validations to unveil the intricate molecular mechanism of IPF. Leveraging three IPF datasets, we identified 817 upregulated and 560 downregulated differentially expressed genes (DEGs). Of these, 14 DEGs associated with copper metabolism were identified, shedding light on the potential involvement of disrupted copper metabolism in IPF progression. Immune infiltration analysis revealed dysregulated immune cell infiltration in IPF, with a notable correlation between copper metabolism‐related genes and immune cells. Weighted gene co‐expression network analysis (WGCNA) identified a central module correlated with IPF‐associated genes, among which STEAP2 emerged as a key hub gene. Subsequent in vivo and in vitro studies confirmed the upregulation of STEAP2 in IPF model. Knockdown of STEAP2 using siRNA alleviated fibrosis in vitro, suggesting potential pathway related to copper metabolism in the pathophysiological progression of IPF. Our study established a novel link between immune cell infiltration and dysregulated copper metabolism. The revelation of intracellular copper overload and upregulated STEAP2 unravelled a potential therapeutic option. These findings offer valuable insights for future research and therapeutic interventions targeting STEAP2 and associated pathways in IPF.
Distracted institutional shareholders and debt maturity
Authors: Cheung Adrian (Wai Kong) , Khoo Joye , Wang Rui 
Published: June 2024

AbstractWe examine whether institutional shareholders’ distraction affects corporate debt maturity decisions. We find that firms with distracted shareholders are associated with lengthened debt maturity. The effect becomes stronger for firms with high information asymmetry or those with high levels of financial constraint. When distraction is high and debt maturity is low, firms hold more cash and use that cash in value‐destroying acquisitions. This supports the prevalence of agency problems when institutional shareholders are distracted. The impact of distraction is persistent and affects the debt maturity decision in the future. Our findings are robust to endogeneity and other concerns.
Revisiting the steatosis‐associated fibrosis estimator score in young Asian subjects with steatotic liver disease and consideration for population variability
Authors: Yang Jiwon , Choi Won‐Mook , Lee Danbi , Shim Ju Hyun , Kim Kang Mo , Lim Young‐Suk , Lee Han Chu , Choi Jonggi 
Published: June 2024

AbstractBackground and AimThe steatosis‐associated fibrosis estimator (SAFE) score has been developed to distinguish clinically significant fibrosis in patients with steatotic liver disease (SLD). However, validation of its performance in Asian subjects is limited. This study aimed to evaluate the performance of the SAFE score in Asian subjects with biopsy‐proven SLD and in different subgroups according to age, sex, and body mass index.MethodsWe retrospectively analyzed 6383 living liver donors who underwent a liver biopsy between 2005 and 2023. Of these, 1551 subjects with biopsy‐proven SLD were included. The performance of the SAFE score was evaluated using areas under the curve and compared with those of the nonalcoholic fatty liver disease fibrosis score (NFS) and fibrosis‐4 index (FIB‐4).ResultsThe prevalence of clinically significant fibrosis in the cohort was 2.2%. The proportion of subjects with a “low‐risk” SAFE score was the highest (91.0%), followed by those with “intermediate‐risk” (7.8%) and “high‐risk” (1.2%) scores. The prevalence of fibrosis in subjects with low‐risk, intermediate‐risk, and high‐risk scores was 1.6%, 6.6%, and 21.1%, respectively. The SAFE outperformed FIB‐4 and NFS (area under the curve: 0.70 vs 0.64 for both NFS and FIB‐4). However, it showed low diagnostic accuracy and sensitivity (27%) at the low cutoff (SAFE < 0) in subjects aged 30–39 years (fibrosis: 1.2%), despite having a high negative predictive value (0.99).ConclusionWhile the SAFE score demonstrates superior performance compared with other noninvasive tests in Asian subjects with SLD, its performance varies across age groups. In younger subjects, particularly, its performance may be more limited.
The neurological core features of the infantile‐onset multisystem neurologic, endocrine, and pancreatic disease: A novel nonsense mutation in an Italian family
Authors: Mammi Alessia , Geroldi Alessandro , Patrone Serena , Gotta Fabio , Origone Paola , Gaudio Andrea , La Barbera Andrea , Sanguineri Francesca , Ponti Clarissa , Iacomino Michele , Traverso Monica , Ferlazzo Edoardo , Schenone Angelo , Pascarella Angelo , Marsico Oreste , Mandich Paola , Bellone Emilia 
Published: June 2024

AbstractAimBiallelic mutations in the PTRH2 gene have been associated with infantile multisystem neurological, endocrine, and pancreatic disease (IMNEPD), a rare autosomal recessive disorder of variable expressivity characterized by global developmental delay, intellectual disability or borderline IQ level, sensorineural hearing loss, ataxia, and pancreatic insufficiency. Various additional features may be included, such as peripheral neuropathy, facial dysmorphism, hypothyroidism, hepatic fibrosis, postnatal microcephaly, cerebellar atrophy, and epilepsy. Here, we report the first Italian family presenting only predominant neurological features.MethodsExtensive neurological and neurophysiological evaluations have been conducted on the two affected brothers and their healthy mother since 1996. The diagnosis of peripheral neuropathy of probable hereditary origin was confirmed through a sural nerve biopsy. Exome sequencing was performed after the analysis of major neuropathy‐associated genes yielded negative results.ResultsWhole‐exome sequencing analysis identified the homozygous substitution c.256C>T (p.Gln86Ter) in the PTRH2 gene in the two siblings. According to American College of Medical Genetics and Genomics (ACMG) guidelines, the variant has been classified as pathogenic.At 48 years old, the proband's reevaluation confirmed a demyelinating sensorimotor polyneuropathy with bilateral sensorineural hearing loss that had been noted since he was 13. Additionally, drug‐resistant epileptic seizures occurred when he was 32 years old. No hepatic or endocrinological signs developed. The younger affected brother, 47 years old, has an overlapping clinical presentation without epilepsy.InterpretationOur findings expand the clinical phenotype and further demonstrate the clinical heterogeneity related to PTRH2 variants. We thereby hope to better define IMNEPD and facilitate the identification and diagnosis of this novel disease entity.
Monoclonal gammopathy‐associated peripheral neuropathies: Uncovering pearls and challenges
Authors: Gonçalves Trajano Aguiar Pires , Donadel Camila Derminio , Frezatti Rodrigo Siqueira Soares , Garibaldi Pedro Manoel Marques , Calado Rodrigo T. , Marques Junior Wilson , Tomaselli Pedro José 
Published: June 2024

AbstractMonoclonal gammopathy‐related peripheral neuropathies encompass a spectrum of clinical presentations in which the monoclonal protein directly damages the tissues, including the peripheral nervous system. Given the prevalence of both peripheral neuropathy and monoclonal gammopathy in the general population, these conditions may overlap in clinical practice, posing a challenge for clinicians in determining causality. Therefore, a comprehensive understanding of primary clinical syndromes and their neurophysiological patterns is of great importance for accurate differential diagnoses and effective treatment strategies. In this article, we examine the main forms of monoclonal gammopathies that affect the peripheral nerve. We explore the clinical and electrophysiological aspects and their correlation with each syndrome's corresponding monoclonal protein type. This knowledge is essential for healthcare professionals to diagnose better and manage patients presenting with monoclonal gammopathy‐related peripheral nervous system involvement.
Utilization of blockchain technology in personalized nursing: A scoping review
Authors: Chen Li , Huang Jie , Zhu DanNi , Yang You 
Published: June 2024

AbstractAim and ObjectiveThis study aims to scrutinize the interconnected concepts, prevailing landscape and efficacy of personalized nursing within the framework of blockchain technology and to proffer a roadmap for prospective scholarly inquiries.BackgroundThe ethos of personalized nursing as a paradigm grounded in human‐centered care has been venerated as the pinnacle of nursing practice. Recent years have witnessed the emergence of groundbreaking technologies, notably blockchain, which have set the stage for the actualization of personalized nursing care. Nevertheless, a lacuna persists in the holistic comprehension surrounding the integration of blockchain technology within the domain of personalized nursing.Design and MethodsWe considered studies published in English from 2018 to the present. Databases searched included CINAHL, Pubmed, MEDLINE, Scopus. Sources of grey literature that were searched included ProQuest Dissertations and Theses. The eligibility of the studies was independently appraised by a pair of researchers. The findings are delineated through narratives and tabular presentations.ResultsThe narrative findings are stratified into three primary domains: (1) the theoretical underpinnings of personalized nursing vis‐à‐vis the integration of blockchain technology; (2) delineation of the specific domains within nursing where blockchain applications are germane to personalized nursing; and (3) the demonstrable impact of blockchain technology on the efficacy of personalized nursing.ConclusionBlockchain technology has wrought profound transformations in the landscape of personalized nursing. As blockchain technology continues to evolve, future scholarship necessitates elucidation on the conceptual intricacies of personalized nursing interfaced with blockchain technology, and broadening of the research purview to encompass a comprehensive understanding of the various applications of personalized nursing.Reporting MethodThis scoping review adhered to relevant EQUATOR guidelines and used the PRISMA‐ScR.
The impact of wearing complete denture in one or both arches, on eating‐related quality of life and patients' perceived need for advice to support eating well: Results from a qualitative study
Authors: Chu Melissa , Ibrahim Amal Mamdouh B. R. , Moores Carly J. , Moynihan Paula 
Published: June 2024

AbstractBackgroundWearing complete denture in one or both arches can impact enjoyment of eating and affect quality of life compared with being dentate. Clinicians focus on issuing technically sound dentures but ignore the impact of wearing dentures on the eating‐related quality of life which affects the success of treatment.ObjectivesThe aim of this research was to qualitatively explore ERQoL in Australian adults wearing complete dentures using a validated questionnaire and through focus groups.MethodsComplete denture wearers (n = 44) were recruited from dental clinics and invited to complete the self‐administered Emotional and Social Issues Related to Eating questionnaire. Responses were categorised under the six questionnaire domains. A subsample of 20 participants who completed the questionnaire were invited to participate in focus groups to identify emerging themes.ResultsTwenty‐three participants (52.3%) completed the questionnaire. Most participants expressed a decline in enjoyment of eating due to reduced ability to eat, longer chewing times and the need to frequently clean dentures while eating. Focus groups (n = 2 × 4 participants) indicated educational materials on eating with dentures would increase recognition of eating problems with dentures and reduce trial and error approaches to dealing with these.ConclusionERQoL is adversely affected by wearing complete dentures due to functional limitations, restricted food choices and adaptive eating behaviours. Patient support for eating well with a complete denture/s wearers is required.
The test of masticating and swallowing solids (ToMaSS): An investigation of applicability and clinical utility in children with orofacial myofunctional disorders
Authors: Lorenz Marlene , Goetze Danae , Sargolzaei Kian , Frank Ulrike 
Published: June 2024

AbstractBackgroundOrofacial myofunctional disorders (OMD) are often associated with limitations of oral ingestion of solid food. The Test of Masticating and Swallowing Solids (ToMaSS) is a simple diagnostic tool to assess and quantify oropharyngeal efficiency while eating a standardised cracker.ObjectivesThe objective of this study was to investigate the applicability and clinical utility of the ToMaSS in children with OMD.MethodsIn this case–control study, data were collected from 18 children between 4 and 11 years with confirmed OMD. Inter‐rater reliability and age effects on the ToMaSS parameters were investigated and the specific performance profile of the OMD children was identified.ResultsInter‐rater reliability was excellent for the ToMaSS parameters ‘bites’ (ICC = .999), ‘masticatory cycles’ (ICC = .961), ‘time’(ICC≧ .999) and good for ‘number of swallows’ (ICC = .810). ‘Masticatory cycles’ and ‘time’ decreased as a function of age with a significant difference in the ‘number of masticatory cycles’ between the youngest (4–6 years) and oldest (10–14 years) participants (p = .006, Z = −2.739). Deviations from normative data in at least one of the four ToMaSS parameters were found in 90% of the OMD children with ‘bites’, and ‘masticatory cycles’ predominantly corresponding to the performances expected in typically‐developing children in younger age groups.ConclusionsThe ToMaSS is a reliable diagnostic instrument and clinically useful to detect limited efficiency of oral solid bolus intake and specific impairments in chewing function and duration of food intake in children with OMD. Our data suggest that OMD is associated with delayed development of efficient solid bolus preparation.
Biomechanism of abnormal stress on promoting osteoarthritis of temporomandibular joint through Piezo1 ion channel
Authors: Li Meng‐Jia , Li Chen‐Xi , Li Jia‐Yu , Gong Zhong‐Cheng , Shao Bo , Zhou Yu‐Chuan , Xu Ying‐Jie , Jia Meng‐Ying 
Published: June 2024

AbstractObjectiveThis study aimed to investigate whether flow fluid shear stress (FFSS)‐mediated signal transduction affects the function of Piezo1 ion channel in chondrocyte and to further explore the role of mechanical overloading in development of temporomandibular joint osteoarthritis (TMJ OA).MethodsImmunohistochemical staining was used to determine the expression of Piezo1 in TMJ OA tissue collected from rat unilateral anterior crossbite (UAC) models. Chondrocytes harvested from normal adult SD rats were treated with FFSS (0, 4, 8, 12 dyn/cm2) in vitro. Immunofluorescent staining, real‐time polymerase chain reaction, western blotting, flow cytometry and phalloidin assay were performed to detect the changes of cellular morphology as well as the expression of Piezo1 and certain pro‐inflammatory and degradative factors in chondrocyte.ResultsImmunohistochemical analysis revealed that significantly increased Piezo1 expression was associated with UAC stimulation (p < .05). As applied FFSS escalated (4, 8 and 12 dyn/cm2), the expression levels of Piezo1, ADAMTS‐5, MMP‐13 and Col‐X gradually increased, compared with the non‐FFSS group (p < .05). Administering Piezo1 ion channel inhibitor to chondrocytes beforehand, it was observed that expression of ADAMTS‐5, MMP‐13 and Col‐X was substantially decreased following FFSS treatment (p < .05) and the effect of cytoskeletal thinning was counteracted. The activated Piezo1 ion channel enhanced intracellular Ca2+ excess in chondrocytes during abnormal mechanical stimulation and the increased intracellular Ca2+ thinned the cytoskeleton of F‐actin.ConclusionsMechanical overloading activates Piezo1 ion channel to promote pro‐inflammation and degradation and to increase Ca2+ concentration in chondrocyte, which may eventually result in TMJ OA.
Efficiency of inoculation methods for the assessment of bacterial halo blight in coffee seedlings
Authors: Oliveira J. M. , Pozza E. A. , Belan L. L. , Freitas M. L. O. , Tedardi V. M. 
Published: June 2024

AbstractBacterial halo blight (BHB), caused byPseudomonas coronafacienspv.garcae(Pcg), is one of the most significant diseases affecting coffee trees worldwide, resulting in considerable damage and notable losses within coffee production systems. Further research into the epidemiology and aetiology of BHB in coffee plants is essential for developing effective management strategies. Understanding the efficiency of each inoculation methodology in inducing symptoms is crucial for advancing this research. Therefore, this study aimed to assess the efficiency of seven Pcg inoculation methods using five concentrations to enhance the highest BHB intensity. The experimental design was a complete randomized block design in a factorial (7 × 5) variance analysis with four replications. The first three pairs of leaves of coffee seedlings of the cultivar Catuaí Vermelho IAC‐99 were inoculated and evaluated for the incidence and severity of BHB. The inoculation methods of Pcg by injury provided higher BHB AUDPCI and AUDPCS values. Among these, the inoculum injection and multi‐needle wounding at inoculum concentrations of 1.6 × 109 CFU mL−1demonstrated higher disease intensity.
Facial Mimicry in Unstructured Dyadic Interactions: A Cross‐Cultural Study
Authors: Chuang Yi‐Chun , Fujiwara Ken 
Published: June 2024

AbstractFacial mimicry, known as the tendency to imitate other individuals' facial muscular movements, is key to establishing successful interpersonal relationships. Studies on various cultures have confirmed this tendency, suggesting that facial mimicry is a universal behavioral pattern in interpersonal communication. However, its cross‐cultural variability is expected because of the influence of cultural norms regarding facial expressions. By focusing on unstructured dyadic interactions, we addressed the unexplored cross‐cultural variability of facial mimicry through a secondary analysis of video data obtained in Japan and Spain and a further analysis of newly collected videos in Taiwan. We also explored the association between the Big Five personality traits and facial mimicry cross‐culturally. To measure facial mimicry, the intensity of each facial action unit movement was quantified using OpenFace, which underwent multidimensional dynamic time warping. First, employing the pseudo‐synchrony paradigm of random data shuffling, we confirmed that interactants displayed facial mimicry beyond chance during their conversation. Second, we found that the extent of mimicry was significantly different among the three cultures; that is, interactants from East Asian cultures (Taiwan, Japan) showed a greater extent of mimicry than those from Western cultures (Spain) even after controlling for unbalanced gender composition in the data. Third, conscientiousness was significantly associated with the degree of mimicry. However, the association between personality traits and mimicry was not consistent across cultures. Overall, this study discusses the importance of cross‐cultural research in facial mimicry, as in the study of facial expressions.
The Effects of Adding Emojis to Text Messages on Emotional Impressions and Recollection of Textual Content
Authors: Suzuki Momoka , Ujiie Yuta , Takahashi Kohske 
Published: June 2024

AbstractEmojis or emoticons are commonly used to convey emotional status to others in text‐based, online communication. While several studies have investigated the influence of emojis on emotional processing, the influence of emojis on the recognition of messages is less understood. In the present study, we investigated the effects of emojis accompanying a short text message on the emotional impressions and memory of the messages. The results suggested that emojis modulated the emotional processing of the messages; the emotional arousal of the messages increased by adding emojis, and the emotional valence of messages was biased towards the valence of emojis. Furthermore, we found that the memory of the text messages was modulated by emojis; the recognition performance of the positive text messages was improved when they appeared with negative emojis. These results implied that emojis would have an impact on cognitive processing, as well as the emotional processing of text messages.
Do the Three Modern Social Conditions—High Existential Security, Education, and Urbanicity—Really Make People Less Religious? A Worldwide Analysis, 1989–2020
Authors: Roberts Louisa L. 
Published: June 2024

AbstractSome versions of secularization theory propose that existential security, education, and urbanicity exert directly measurable negative effects on religiosity cross‐culturally. However, few studies have tested this using longitudinal data. Nor have researchers adequately examined how much the relationship between these modern social conditions (MSCs) and religiosity varies society‐to‐society. This study addresses these limitations in a series of new analyses, using 1989–2020 World/European Values Survey data from approximately 100 countries. Results suggest that the three MSCs do not exert independent, negative effects on religiosity in general, at least not in the short or medium term. Indeed, national‐average increases in these MSCs were not found to predict decreased religiosity. And, interestingly and unexpectedly, the direction of individual‐level relationships between each MSC and religiosity varied greatly between countries and world regions. These findings suggest scholars should probably look elsewhere to explain why average religiosity has decreased in some world locations over recent decades.
Far‐red light increases maize volatile emissions in response to volatile cues from neighbouring plants
Authors: Escobar‐Bravo Rocío , Schimmel Bernardus C. J. , Zhang Yaqin , Wang Lei , Robert Christelle A. M. , Glauser Gaétan , Ballaré Carlos L. , Erb Matthias 
Published: June 2024

AbstractPlants perceive the presence and defence status of their neighbours through light and volatile cues, but how plants integrate both stimuli is poorly understood. We investigated if and how low Red to Far red light (R:FR) ratios, indicative of shading or canopy closure, affect maize (Zea mays) responses to herbivore‐induced plant volatiles (HIPVs), including the green leaf volatile (Z)−3‐hexenyl acetate. We modulated light signalling and perception by using FR supplementation and a phyB1phyB2 mutant, and we determined volatile release as a response readout. To gain mechanistic insights, we examined expression of volatile biosynthesis genes, hormone accumulation, and photosynthesis. Exposure to a full blend of HIPVs or (Z)−3‐hexenyl acetate induced maize volatile release. Short‐term FR supplementation increased this response. In contrast, prolonged FR supplementation or constitutive phytochrome B inactivation in phyB1phyB2 plants showed the opposite response. Short‐term FR supplementation enhanced photosynthesis and stomatal conductance and (Z)−3‐hexenyl acetate‐induced JA‐Ile levels. We conclude that a FR‐enriched light environment can prompt maize plants to respond more strongly to HIPVs emitted by neighbours, which might be explained by changes in photosynthetic processes and phytochrome B signalling. Our findings reveal interactive responses to light and volatile cues with potentially important consequences for plant‐plant and plant‐herbivore interactions.