bluuebunny/crossref_metadata_2025_split huggingface dataset:
Visual Function After Bilateral Implantation of Apodized Diffractive Multifocal IOL With a +3.0 or +4.0 D Addition
Authors: Sun Yi , Zheng Danying , Song Tingting , Liu Yizhi 
Published: May 2011

BACKGROUND AND OBJECTIVE:
To evaluate uncorrected distance, intermediate, and near visual acuity (VA), uncorrected near stereoacuity, the preferred reading distance, and reading speed after bilateral implantation of AcrySof ReSTOR SN6AD1 or SN6AD3 multifocal intraocular lens (IOL) (Alcon Laboratories, Fort Worth, TX).

PATIENTS AND METHODS:
Forty patients (80 eyes) from our hospital were prospectively enrolled in either the SN6AD1 group or the SN6AD3 group. There were 20 patients (40 eyes) in each group. Uncorrected distance and near VA, uncorrected intermediate VA at 40, 63, and 100 cm under high and low contrast, defocus curve, preferred reading distance, uncorrected near stereoacuity, and reading speed were evaluated 3 months postoperatively.

RESULTS:

Uncorrected intermediate VA at 40, 63, and 100 cm with high or low contrast was significantly better in the SN6AD1 group than in the SN6AD3 group (
P
< .05), with no difference in uncorrected distance VA or near VA (
P
> .05). The preferred reading distance in both groups was 38.5 and 32.8 cm, respectively. There were no statistically significant differences between groups in uncorrected near stereoacuity and reading speed (56.7 ± 45.4 vs 52.5 ± 35.4 seconds of arc and 174.2 ± 65.0 vs 195.3 ± 45.8 words per minute, respectively).

CONCLUSION:
Patients receiving the SN6AD1 IOL achieved better intermediate VA under high or low contrast and a more comfortable reading distance than patients receiving the SN6AD3 IOL without compromising uncorrected near and distance VA, uncorrected near stereoacuity, and reading speed.
B Cell Maturation Antigen Deficiency Exacerbates Lymphoproliferation and Autoimmunity in Murine Lupus
Authors: Jiang Chao , Loo William M. , Greenley Erin J. , Tung Kenneth S. , Erickson Loren D. 
Published: May 2011

Abstract
Systemic lupus erythematosus and its preclinical lupus-prone mouse models are autoimmune disorders involving the production of pathogenic autoantibodies. Genetic predisposition to systemic lupus erythematosus results in B cell hyperactivity, survival of self-reactive B cells, and differentiation to autoantibody-secreting plasma cells (PCs). These corrupt B cell responses are, in part, controlled by excess levels of the cytokine BAFF that normally maintains B cell homeostasis and self-tolerance through limited production. B cell maturation Ag (BCMA) is a receptor for BAFF that, under nonautoimmune conditions, is important for sustaining enduring Ab protection by mediating survival of long-lived PCs but is not required for B cell maturation and homeostasis. Through analysis of two different lupus-prone mouse models deficient in BCMA, we identify BCMA as an important factor in regulating peripheral B cell expansion, differentiation, and survival. We demonstrate that a BCMA deficiency combined with the lpr mutation or the murine lupus susceptibility locus Nba2 causes dramatic B cell and PC lymphoproliferation, accelerated autoantibody production, and early lethality. This study unexpectedly reveals that BCMA works to control B cell homeostasis and self-tolerance in systemic autoimmunity.
CD300F Blocks Both MyD88 and TRIF-Mediated TLR Signaling through Activation of Src Homology Region 2 Domain-Containing Phosphatase 1
Authors: Lee Sang-Min , Kim Eun-Ju , Suk Kyoungho , Lee Won-Ha 
Published: May 2011

Abstract
CD300F is known to exhibit inhibitory activity in myeloid cells through its intracellular ITIM. To investigate the effect of CD300F stimulation on TLR signaling, the human acute monocytic leukemia cell line THP-1 was treated with CD300F-specific mAbs or two synthetic peptides that represented the ITIM-like domains of CD300F. Treatment with these agents blocked TLR2-, 3-, 4-, and 9-mediated expression of proinflammatory mediators such as IL-8 and matrix metalloproteinase-9. The luciferase reporter assay in 293T cells and Western blot analysis of THP-1 cells revealed that these inhibitory actions were effective in pathways involving MyD88 and/or TRIF of TLR signaling and associated with marked suppression of IκB kinase activation, phosphorylation/degradation of IκB, and subsequent activation of NF-κB. Use of specific inhibitors and immunoprecipitation analysis further indicated that the inhibitory effects were mediated by Src homology 2 domain-containing phosphatase-1, a protein tyrosine phosphatase with inhibitory activity in hematopoietic cells. These data indicate that CD300F is an active regulator of TLR-mediated macrophage activation through its association with Src homology 2 domain-containing phosphatase-1 and that the synthetic peptides can be applied for the regulation of immune responses that are induced by TLRs.
Leukotriene B4 Mediates Neutrophil Migration Induced by Heme
Authors: Monteiro Ana Paula T. , Pinheiro Carla S. , Luna-Gomes Tatiana , Alves Liliane R. , Maya-Monteiro Clarissa M. , Porto Barbara N. , Barja-Fidalgo Christina , Benjamim Claudia F. , Peters-Golden Marc , Bandeira-Melo Christianne , Bozza Marcelo T. , Canetti Claudio 
Published: May 2011

Abstract
High concentrations of free heme found during hemolytic events or cell damage leads to inflammation, characterized by neutrophil recruitment and production of reactive oxygen species, through mechanisms not yet elucidated. In this study, we provide evidence that heme-induced neutrophilic inflammation depends on endogenous activity of the macrophage-derived lipid mediator leukotriene B4 (LTB4). In vivo, heme-induced neutrophil recruitment into the peritoneal cavity of mice was attenuated by pretreatment with 5-lipoxygenase (5-LO) inhibitors and leukotriene B4 receptor 1 (BLT1) receptor antagonists as well as in 5-LO knockout (5-LO−/−) mice. Heme administration in vivo increased peritoneal levels of LTB4 prior to and during neutrophil recruitment. Evidence that LTB4 was synthesized by resident macrophages, but not mast cells, included the following: 1) immuno-localization of heme-induced LTB4 was compartmentalized exclusively within lipid bodies of resident macrophages; 2) an increase in the macrophage population enhanced heme-induced neutrophil migration; 3) depletion of resident mast cells did not affect heme-induced LTB4 production or neutrophil influx; 4) increased levels of LTB4 were found in heme-stimulated peritoneal cavities displaying increased macrophage numbers; and 5) in vitro, heme was able to activate directly macrophages to synthesize LTB4. Our findings uncover a crucial role of LTB4 in neutrophil migration induced by heme and suggest that beneficial therapeutic outcomes could be achieved by targeting the 5-LO pathway in the treatment of inflammation associated with hemolytic processes.
GM-CSF–Based Fusion Cytokines as Ligands for Immune Modulation
Authors: Williams Patrick , Galipeau Jacques 
Published: May 2011

Abstract
Chromosomal translocations that combine distinct functional domains of unrelated proteins are an experiment in nature. They demonstrate how endogenous regulatory checkpoints can be overridden by altered cell biochemistry, informing a means to engineering an aberrant signal that the cell is incapable of counterregulating. Thus, our laboratory and others have synthesized fusions of GM-CSF with peptides, ILs, and chemokines, which we have termed fusokines, with the aim of inducing an enhanced immune response against cancer, aiming to overcome the maladapted biological processes causing disease. In doing so, we found that these fusokines did not behave as merely the sum of their natural unfused counterparts, but as entirely novel ligands co-opting their cognate receptor to communicate a unique message to responsive cellular targets. In this review, we discuss how fusion proteins combining different bioactive ligands can alter immune responses and briefly discuss the regulatory pathways that they circumvent.
Cutting Edge: Identification of a Motile IL-17–Producing γδ T Cell Population in the Dermis
Authors: Gray Elizabeth E. , Suzuki Kazuhiro , Cyster Jason G. 
Published: May 2011

Abstract
Dendritic epidermal T cells (DETCs) are a well-studied population of γδ T cells that play important roles in wound repair. In this study, we characterize a second major population of γδ T cells in the skin that is present in the dermis. In contrast to DETCs, these Vγ5-negative cells are IL-7RhiCCR6hi retinoic acid-related orphan receptor γt+ and are precommitted to IL-17 production. Dermal γδ T cells fail to reconstitute following irradiation and bone marrow transplantation unless the mice also receive a transfer of neonatal thymocytes. Real-time intravital imaging of CXCR6GFP/+ mouse skin reveals dermal γδ T cells migrate at ∼4 μm/min, whereas DETCs are immobile. Like their counterparts in peripheral lymph nodes, dermal γδ T cells rapidly produce IL-17 following exposure to IL-1β plus IL-23. We have characterized a major population of skin γδ T cells and propose that these cells are a key source of IL-17 in the early hours after skin infection.
A Retrospective (Post-Marketing) Case Series of Patients Receiving Intramuscular (IM) Olanzapine outside of Product Doses and Indications (Off-Label): Assessing Safety and Tolerability
Authors: Lamoure Joel W. , Rudnick Abraham 
Published: May 2011

Introduction Intramuscular (IM) olanzapine has been approved for the management of acute agitation/psychosis secondary to schizophrenia, bipolar disorder, and dementia, in a dose not to exceed 10 mg per injection and 30 mg per day. Many other clinical situations exist in which patients are acutely agitated and in whom IM olanzapine might be warranted at recommended or higher doses. We systematically reviewed data on 8 such patients, during 10 inpatient admissions, to assess the overall safety and tolerability of this approach. Methods Using a standardized data recording sheet, we retrospectively collected information on 10 inpatient admissions between 2004 and 2007, in which IM olanzapine was administered outside of product dosing and/or indication guidelines. We present composite data and the details of each case individually. Results Records of eight patients (5 males, 3 females; mean age/age range = 43.9/18–77 years) were reviewed over 10 inpatient admissions, 5 to Psychiatry, 4 to Surgery, and one to Internal Medicine. Indications for admission were mania (2), schizophrenia (1), schizoaffective disorder (2), brain injury (2), sepsis (1), sepsis with respiratory failure (1), and cancer (1). Five patients were intoxicated with or experienced withdrawal from alcohol and/or drugs, likely adding to their agitation. Only one symptomatic episode of orthostatic hypotension occurred, in a patient with comorbid C. difficile colitis, which resolved when antibiotics were initiated and olanzapine discontinued; olanzapine IM was successfully reinstituted 2 days later, without incident. No other significant adverse events or side effects were ascribed to IM olanzapine. Conclusions Intramuscular olanzapine may be safe to use outside of product dosing and indication guidelines. Randomized clinical trials are warranted to study such off-label use further.
Safety and Efficacy of Armodafinil in the Treatment of Excessive Sleepiness
Authors: Brown Jamie N. , Wilson Dustin T. 
Published: May 2011

Objective To review the efficacy and safety of armodafinil for the treatment in patients with excessive sleepiness. Data sources Literature was accessed via MEDLINE (1966–February 2011) and EMBASE (1980–February 2011) using the medical subject heading terms armodafinil and sleep. Study selection and data extraction All English-language, peer-reviewed publications were analyzed for relevance. Studies appropriate to the objective were evaluated if they prospectively assessed the effectiveness of armodafinil in patients with excessive sleepiness in a multiple-dose, comparator trial. The literature search identified published reports of 7 randomized, placebo-controlled studies. Data synthesis Armodafinil is a wakefulness-promoting agent used in the treatment of patients with excessive sleepiness and is the R-enantiomer of modafinil. Studies have demonstrated that armodafinil may be effective and safe when used in patients with obstructive sleep apnea, circadian rhythm disorders, and narcolepsy. Although the studies identified had limited sample sizes, they consistently demonstrated improvement on various efficacy rating scales for sleep. Study durations ranged from 3 days to 12 weeks, with doses ranging from 50 mg to 250 mg daily. The most common adverse effects associated with armodafinil therapy were headache, nausea, diarrhea, dizziness, and anxiety, although increases in systolic blood pressure and pulse rate were also reported. Conclusion Current evidence suggests that armodafinil significantly improves wakefulness in patients with excessive sleepiness in studies up to 12 weeks. Long-term effectiveness and safety cannot be adequately determined at this time. Although armodafinil should be considered safe for use, health-care providers should monitor for adverse effects, particularly cardiovascular complications.
Review of Occupational Therapy Research in the Practice Area of Children and Youth
Authors: Bendixen Roxanna M. , Kreider Consuelo M. 
Published: May 2011

AbstractWe conducted a systematic review focusing on articles in the occupational therapy practice category of Children and Youth published in the American Journal of Occupational Therapy over the 2-yr period of 2009–2010. We used the frameworks of the International Classification of Functioning, Disability and Health (ICF) and Positive Youth Development (PYD) to explore occupational therapy research progress toward the goals of the Centennial Vision. We organized 46 research articles by research type and classified them within these two frameworks. Most reviewed published research investigated variables representing constructs falling within the ICF domains of Body Functioning and Activity. The effect of occupational therapy interventions on PYD resided primarily in building competence. To meet the tenets of the Centennial Vision, occupational therapists must document changes in children’s engagement in everyday life situations and build the evidence of occupational therapist’s efficacy in facilitating participation.
Relationships Between Sensory Modulation and Social Supports and Health-Related Quality of Life
Authors: Kinnealey Moya , Koenig Kristie Patten , Smith Sinclair 
Published: May 2011

Abstract
OBJECTIVE. We explored the relationships between sensory modulation and health-related quality of life (HRQOL), social supports, and mental health symptoms of anxiety and depression.
METHOD. Twenty-eight adult volunteers ages 18–60 participated in the study. Fourteen adults were sensory overresponsive (SOR), and 14 adults in a matched comparative group were not sensory overresponsive (NSOR). All participants were tested using self-administered measures of sensory processing.
RESULTS. Significant differences were found between SOR and NSOR groups on symptoms of anxiety, depression, and 4 of 8 indicators of HRQOL.
CONCLUSION. Several analyses exploring the relationships among the variables tested suggest that sensory response style, whether comparing SOR and NSOR groups or exploring the correlation of the response quadrants of the Adolescent/Adult Sensory Profile, appears significantly and differentially related to symptoms of affective mental health and quality-of-life indicators, including social participation.
Journal Quality Metrics: Options to Consider Other Than Impact Factors
Authors: Brown Ted 
Published: May 2011

AbstractJournal quality metrics (also referred to as bibliometrics), such as impact factors, are increasingly being used as a measure of researchers’ and educators’ success and prestige. Occupational therapists who submit articles to peer-reviewed journals may face a professional and research dilemma: Do they submit their articles to journals that largely have a professional audience and potentially do not have an impact factor, or do they opt not to publish their research material in occupational therapy–oriented journals? Occupational therapy authors can consider other journal quality metric alternatives, in addition to the impact factor option, including the Eigenfactor Score, Article Influence Score, h-index, SCImago Journal Rank (SJR), Source Normalised Impact per Paper (SNIP), and discipline-specific generated journal quality measures. These other journal quality metrics can be important reference points for occupational therapists who publish and may encourage authors to publish in journals relevant to the discipline. This process, in turn, will build the occupational therapy body of knowledge as well as provide an essential, growing reference source for evidence-based practice.
Using the LOTCA to Measure Cultural and Sociodemographic Effects on Cognitive Skills in Two Groups of Children
Authors: Josman Naomi , Abdallah Taisir M. , Engel-Yeger Batya 
Published: May 2011

Abstract
OBJECTIVES. Our objectives were (1) to compare the differential effects of cultural and sociodemographic variables on the cognitive performance of Israeli and Palestinian children, (2) to examine validity of the Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) for kindergarten children, and (3) to determine the feasibility of using the LOTCA as a screening tool for assessing Palestinian children’s cognitive abilities.
METHOD. Participants were 101 Jewish Israeli and 125 Muslim Palestinian children, ranging in grade from kindergarten to second grade.
RESULTS. Israeli children achieved significantly higher scores than the Palestinian children on most LOTCA domains. We obtained significant Grade × Cultural Group interaction effects (F[10, 364] = 1.73, p &lt; .001, effect size [ES] − η2 = .045) and also found a significant Cultural Group × Mother's Education interaction (F[5, 184] = 2.49, p &lt; .05, ES − η2 = .064).
CONCLUSION. Cultural and sociodemographic variables appear to affect cognitive performance. The LOTCA revealed cognitive differences between the cultural groups and school grades and may thus constitute an appropriate evaluation tool focusing on children’s school grade promotion.
Aligning operant resources for global performance: An assessment of supply chain human resource management
Authors: Richey R Glenn , Hilton Chadwick B , Harvey Michael G , Beitelspacher Lauren Skinner , Tokman Mert , Moeller Miriam 
Published: May 2011

AbstractPurpose:The intent of the paper is to develop the service marketing logic (S-D logic) strategy that is centered on service as a means to differentiate global strategy from those of competitors. The context of the paper is to examine S-D logic in global supply chains.Design/Methodology:The paper is a theory driven conceptual piece.Findings:Globalization emphasizes complex interconnected systems, while S-D logic emphasizes the importance of leveraging operant resources in order to achieve sustainable competitive advantage. Both S-D logic and globalization apply in the supply chain context. This paper focuses on the global supply chain and the importance of leveraging service based operant resources. Because the focus of management has shifted from a domestic to a more complex, three-dimensional network, it is critical for practitioners and researchers to understand how to optimize service based operant resources in the global marketplace.Practical Implications:Because the focus of management has shifted from a domestic to a more complex, three-dimensional global network, it is critical for practitioners and researchers to understand how to optimize service based operant resources in the global marketplace. We suggest that in this dynamic marketplace, both globalization and S-D logic are required to fully explain supply chain performance. Specifically, we suggest that managers develop a global ‘supply-chain management’ perspective allowing for the key operant resource – human capital – to create synergistic partner relationships and customer experiences resulting in superior performance.Originality/Value:This is one of the first (if not the first) paper that examines S-D logic in a global context. This move forward from the domestic orientation of many/most of the recent literature provides the foundation for future global research into the S-D logic.
Salesperson engagement and performance: A theoretical model
Authors: Medhurst Adrian , Albrecht Simon 
Published: May 2011

AbstractSales performance is widely regarded as an important index of individual and organizational performance. Sales employees require access to organizational and job resources as well as personal resources in order to function effectively. An individual-level salesperson performance model is proposed that draws from the motivational process represented in the Job Demands-Resources Model (Bakker & Demerouti, 2007). Organizational and job resources are conceptualized in terms of employee involvement climate (Riordan, Vandenberg, & Richardson, 2005). Personal resources are conceptualized in terms of employees' psychological capital (Luthans & Youssef, 2004). The model delineates how employee involvement climate influences engagement; how psychological capital influences performance; how employee involvement climate and psychological capital interact to influence employee engagement; and how, in turn, engagement impacts salesperson performance. The model will potentially prove useful to human resource managers, organizational development practitioners, and sales managers aiming to up-skill and more fully involve and engage their salespeople in order to optimize salesperson performance.
A Case Study of Witness Consistency and Memory Recovery Across Multiple Investigative Interviews
Authors: Orbach Yael , Lamb Michael E. , La Rooy David , Pipe Margaret‐Ellen 
Published: May 2011

SummaryAccess to audio recordings of five interviews (Interviews 2–6), and to the interviewer's contemporaneous notes during an initial unrecorded interview, made it possible to assess consistency across repeated attempts by a 9‐year‐old to describe her older sister's abduction from their shared bedroom. Information provided in each of the interviews was systematically analysed to determine whether each unit of information was new, consistent (repeated) or contradictory in relation to earlier reported information and whether any informative detail provided in the witness' initial interview was subsequently omitted. In addition, the witness' accounts were compared with details provided by the victim upon her rescue. This case analysis is particularly informative in light of widespread professional concerns about the effects of repeated interviewing on the quality and accuracy of children's accounts of experienced events. Copyright © 2011 John Wiley & Sons, Ltd.
Delay‐dependent model reduction for continuous‐time switched state‐delayed systems
Authors: Wang Dong , Wang Wei , Shi Peng 
Published: May 2011

AbstractThis paper studies the problem of exponential H∞ model reduction for continuous‐time switched delay system under average dwell time (ADT) switching signals. Time delay under consideration is interval time varying. Our attention is focused on the construction of the desired reduced order models, which guarantee that the resulting error systems under ADT switching signals are exponentially stable with an H∞ norm bound. By introducing a block matrix and making use of the ADT approach, delay‐dependent sufficient conditions for the existence of reduced order models are derived and formulated in terms of strict linear matrix inequalities (LMIs). Owing to the absence of non‐convex constraints, it is tractable to construct an admissible reduced order model. The effectiveness of the proposed methods is illustrated via two numerical examples. Copyright © 2011 John Wiley & Sons, Ltd.