bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plant-derived Exosomes: Pioneering Breakthroughs in Therapeutics, Targeted Drug Delivery, and Regenerative Medicine
Authors: Dutta Srabona , Ghosh Sourav , Rahaman Monosiz , Chowdhury Sejuti Ray 
Published: June 2024

Abstract:
Small extracellular vesicles called exosomes, which cells release, have drawn a lot of attention
recently because of their ability to serve as therapeutic delivery systems for drugs and regenerative
medicine applications. The investigation of plant-based exosomes as a cutting-edge platform
for drug administration has emerged as an enticing research topic. A summary of the pharmaceutical
feasibility of exosomes generated from plants and their uses in drug delivery along with regenerative
medicine are the goals of this review study. Plant exosomes can be combined into nanoparticlebased
medication delivery systems to increase their stability, targeting, and cargo delivery capabilities.
By loading plant exosomes with therapeutic compounds and encapsulating them within nanoparticles,
controlled release and targeted distribution to specific cells or tissues may be achieved. In
gene therapy, plant exosomes can be modified to carry nucleic acids like plasmid DNA, siRNA, or
miRNA. Effective gene delivery and therapeutic gene expression regulation can be accomplished by
encasing nucleic acids in exosomes or surface-modifying exosomes to improve their interaction with
target cells. In this review, we through the history and features of plant exosomes, examine how they
differ from mammalian exosomes, and consider how they may be used for gene therapy, tissue regeneration,
and targeted medication delivery. The difficulties and prospects for creating exosomebased
plant medicines are also explored.
La Formación de Grado en Hospitales
Authors: Lucarelli Elisa , Filkelstein Claudia 
Published: June 2024

Los resultados de la investigación contenida en este artículo se ubican en el área de la Didáctica Universitaria, disciplina de conformación reciente que tiene como objeto de estudio la enseñanza y el currículum en el nivel. La investigación se propuso comprender las modalidades de formación en la profesión del futuro médico que se adoptan en un Hospital Asociado a la Facultad de Medicina de la Universidad de Buenos Aires, con la intención de poder generar conocimiento acerca de los procesos de enseñanza que llevan a cabo los docentes responsables de un espacio curricular externo a la sede Facultad destinado a la formación en la profesión. Con estos propósitos se parte de supuestos que sostienen que la articulación teoría-práctica es un elemento clave en los procesos de formación en la profesión y, a la vez, que esta formación requiere de aprendizajes complejos que se van articulando progresivamente. La investigación sigue una lógica de generación conceptual (Sirvent y Rigal, 2023), abordándose en el análisis de los datos obtenidos a través de entrevistas, observaciones de clases y consultas de documentos. Se presentan los resultados de la investigación en relación con las siguientes dimensiones: la articulación teoría práctica, la historia de la cátedra, las concepciones acerca de la formación y aportes a la construcción de la identidad profesional del futuro médico.
Pride and Prejudice: What Influences Australians’ Attitudes towards Changing the Date of Australia Day?
Authors: Mortimer-Royle Eliza , Webb Stephanie , McLinton Sarven , Watkins Michael , Clark Yvonne 
Published: June 2024

Australia Day, celebrated on January 26, is rooted in Australia’s
colonial history and causes pain for many of Australia’s First Peoples.
This study was the first to investigate predictors of Australians’
attitudes towards the date, whilst exploring whether intervention may
improve attitudes towards a date-change. An Australian community sample
( N=559) were recruited through social media for an anonymous survey.
Participants indicated their support for date-change, and responded to a
variety of demographic (e.g., Age) and sociodemographic (e.g., Racism)
questions, then being randomly allocated to an intervention statement,
indicating their final attitudes post-intervention. Findings suggest
sociodemographic factors were more important predictors than
demographics, with Racism ( β =.50***), Traditionalism ( β
=.18**), Patriotism ( β =.13*) and Age ( β =.10*)
significantly predicting participants’ date-change resistance. Racism
demonstrated the most predictive strength, underscoring the importance
of a date-change, with those open to change often identifying any
alternative date should not offend First Peoples. In addition,
intervention produced significant improvement in participants’
date-change attitudes, among those able to become more open to a
date-change; however, differences were not present between intervention
conditions. This illuminates the factors predicting Australians’
attitudes towards Australia Day, whilst demonstrating a potential path
towards date-change through intervention.

If you wish to learn more about this study, please contact the
primary author
at morea005@mymail.unisa.edu.au or
find
the published article in Analyses of Social Issues and Public Policy.
Analysis Of the Quality of Childcare Services Using the Servqual Method and The Zone of Tolerance Method (Case study: Yayasan Peduli Lingkungan dan Sosial Indonesia)
Authors: Suwanto M , Hidayat Hidayat , Negoro Yanuar Pandu 
Published: June 2024

The purpose of this study is to use SERVQUAL and the Zone of Tolerance methodologies to evaluate daycare facilities. Research was carried out to comprehend the elements that impact the quality of childcare services to enhance the experience and happiness of service users. A quantitative descriptive-analytical technique was used. Questionnaires were sent to parents who used early childhood care programs to gather data. To assess the gap between customer expectations and perceptions of service quality, the obtained data was analysed using the SERVQUAL technique. The Zone of Tolerance approach was also used to estimate the degree of consumer satisfaction with the services delivered. Staff neatness and service costs/tariffs came out positively in the Servqual gap analysis (0.150 and 0.117, respectively). Two positive MMS value characteristics were produced using the zone of tolerance approach. The zone of tolerance encompasses two characteristics: the ability to respond quickly and efficiently while delivering services (0.017, -0.067) and the capacity to meet customers' unique requirements (0.017, -0.100). The sufficient service category includes five service qualities; if any of these are no longer acceptable to clients, the service must be corrected quickly. Keywords: service quality, child care, Servqual, zone of tolerance
Keanekaragaman Vegetasi dan Pola Persebaran Pohon di Mata Air Kalisegoro 2 Kecamatan Gunungpati
Authors: Alfathqi Rheza Rizky , Julpa Ira Sopiana , Mauliya Durrotul Jahroo , Ni’matuzzahroh Ni’matuzzahroh , Hartanto Naufal , Haris Amnan , Fariz Trida Ridho , Jabbar Abdul 
Published: June 2024

Human life on earth cannot be separated from water. Water is an absolute necessity that humans need. Water needs can be obtained from 2 sources, namely water from the surface and water from the ground. Springs are a source of water obtained from groundwater. Kalisegoro 2 spring is one of the springs in Gunung Pati District, Semarang City. This spring is in Kalisegoro Village where the surrounding land cover is vegetation. This type of research is quantitative in the form of analysis of species diversity and tree distribution patterns. The aim of this research is to determine the diversity of tree species and tree distribution patterns in Kalisegoro 2 springs in Gunung Pati District. The results of this research show that the diversity of vegetation in the Kalisegoro 2 springs amounts to 145 individuals and 10 types of species, the Swietenia mahagoni species is the dominant species found at the Kalisegoro 2 springs location with an INP of 0.59. The vegetation diversity index at Kalisegoro 2 springs is included in the medium category in the range 1<H'<3. The distribution pattern of trees in the Kalisegoro 2 spring is quite even, this is known through the tracking method that has been carried out in the area around the spring. ABSTRAKKehidupan manusia di muka bumi tidak dapat terlepas dari air. Air merupakan suatu kebutuhan mutlak yang dibutuhkan oleh manusia. Kebutuhan air dapat diperoleh melalui 2 sumber yakni air dari permukaan dan air tanah. Mata air merupakan salah satu sumber air yang bersumber dari air tanah. Mata air Kalisegoro 2 merupakan salah satu mata air yang berada di Kecamatan Gunungpati Kota Semarang, mata air ini terdapat di Kelurahan Kalisegoro yang tutupan lahan sekitarnya berupa vegetasi. Jenis penelitian ini adalah kuantitatif berupa analisis keanekaragaman jenis dan pola penyebaran pohon. Tujuan dari penelitian ini adalah untuk mengetahui keanekaragaman jenis pohon dan pola persebaran pohon di sekitar mata air. Hasil penelitian ini menunjukkan keanekaragaman vegetasi di mata air kalisegoro 2 berjumlah 145 individu dan 10 jenis spesies, spesies Swietenia mahagoni merupakan spesies dominan yang ditemukan di lokasi mata air Kalisegoro 2 dengan jumlah INP sebesar 0,59. Indeks keanekaragaman vegetasi pada mata air Kalisegoro 2 termasuk dalam kategori sedang karena berada pada rentang 1<H'<3. Pola persebaran pohon pada mata air Kalisegoro 2 sudah cukup merata, hal ini diketahui melalui metode tracking yang telah dilakukan di area sekitar mata air.
Teknik Miking Spaced Pair: Penggunaan Mikrofon dalam Proses Rekaman Instrumen Baby Grand Piano
Authors: Putra Zakarias Aria Widyatama 
Published: June 2024

Piano merupakan instrumen akustik dengan organologi dan konstruksi bunyi yang rumit. Proses rekaman instrumen piano terutama pada baby grand piano memiliki berbagai opsi dan alternatif yang perlu untuk diujicobakan. Pianis dan sound engineer yang dalam penelitian ini disasarkan oleh mahasiswa, belum mengetahui secara yakin akan proses perekaman dan teknik miking. Oleh karena itu, menjadi tujuan penelitian ini adalah untuk mendeskripsikan teknik spaced pair dan penggunaan mikrofon dalam proses rekaman instrumen baby grand piano yang dilakukan di Ruang Piano Program Studi Pendidikan Seni Pertunjukan, FKIP, Universitas Tanjungpura. Metode kualitatif dengan strategi studi kasus mencoba mengungkap penelitian semi eksperimen ini secara naratif. Temuan data penelitian yang menggunakan aktivitas maupun tindakan proses rekaman serta observasi, wawancara, dan dokumentasi kemudiaan ditindak dalam kesahihan data secara perpanjangan pengamatan dan triangulasi sumber. Penulisan hasil penelitian dikonstruksi berdasarkan model interaktif. Tuaian ujicoba teknik miking spaced pair dari penelitian ini menempatkan posisi kedua sebagai pilihan terbaik dan benar. Hal tersebut dibuktikan dengan hasil rekaman pada EQ FLS yang menerangkan gelombang frekuensi stabil pada aspek lower, middle, dan high secara stabil dan kuat serta penggunaan mikrofon kondensor stereo. Penelitian ini memiliki kekuatan untuk menambah literasi akan teknik miking, penggunaan mikrofon, dan proses perekaman instrumen musik akustik bagi pianis, sound engineer, maupun mahasiswa yang memiliki keterampilan serupa.
Pandemic life in families with health anxiety symptoms, parental perspectives
Authors: Dalgaard Ida Kathrine , Rask Charlotte Ulrikka , Bilenberg Niels , Hulgaard Ditte Roth 
Published: June 2024

Abstract

Background
The covid-19 pandemic has influenced children and parents worldwide. The pandemic has also been suggested to especially affect and exacerbate health anxiety (HA) symptoms in children and adolescents. However, there is limited understanding of the potential mechanisms challenges of families where parents themselves experience mental health issues such as high degree of HA symptoms.

Objective
The aim of this study was to explore parental experiences of pandemic life in families with continuously high levels of HA symptoms during the covid-19 pandemic.

Method
Six parents, identified with high levels of HA symptoms, participated in qualitative individual semi-structured interviews. Interviews were analysed according to Interpretative Phenomenological Analysis principles.

Results
Three main themes emerged. Theme 1) “Anxious children in a pandemic world” explores how pandemic – independent child factors including anxious temperament may have influenced the child pandemic experience. Theme 2) “Parental influences on child anxiety” describes parental reflections on their possible influence on child anxious thoughts. Theme 3) “Living with pandemic guidelines and restrictions” demonstrates the varying parental experiences of interventions and how these may affect HA thoughts.

Conclusion
Parents who themselves experience HA symptoms see their children, who also experience HA symptoms, to be particularly susceptible and vulnerable to both content and rhetoric of pandemic information. These children may however, experience school lockdown to be anxiety relieving. Parents who themselves have illness-related fears may not see themselves as perpetuating for their child's anxious thoughts.
ERP Implementation Success: Impact of Critical Factors and Employee Diversity at PT. ALAM Palm Plantation in North Sumatra
Authors: Junaidi Koko , Rahmanta  , Chalil Diana , Wibowo Rulianda P 
Published: June 2024

Objectives: This academic article examines the influence of workforce diversity, business process improvement, top management commitment, and training on the success of ERP implementation at PT. Anugerah Langkat Makmur in North Sumatra. The impact of workforce diversity on the success of ERP implementation is proposed as a research novelty.

Methods: Data were obtained by surveying 94 employees using ERP software. The analysis method used was Partial Least Squares Structural Equation Modeling (PLS-SEM) with Smart PLS software. This study also aims to test direct relationships between workforce diversity and successful ERP implementation; business process improvement and successful ERP implementation; top management commitment and business process improvement; top management commitment and successful ERP implementation; top management commitment and training; and training and successful implementation.

Results: The results showed that workforce diversity, business process improvement, top management commitment, and training had a positive impact on the success of ERP implementations. Additionally, all direct relationships tested in this study were positive and significant.

Conclusion: The study concludes that the success of ERP implementation at PT. Anugerah Langkat Makmur is positively influenced by workforce diversity, business process improvement, top management commitment, and training. This highlights the importance of these factors in achieving successful ERP outcomes, with workforce diversity emerging as a significant contributor.
A relação entre o tratamento e a vacinação da COVID-19 e o agravamento ou incidência de complicações cardiovasculares
Authors: Vieira Leonardo Anício Viana , Almeida Guilherme Nóbrega , Scheis Giordano , Munhoz Lucas Rodrigues , Dantas Renata Aparecida Elias 
Published: June 2024

Objetivo: Analisar a relação entre tratamento medicamentoso e vacinas da COVID-19 e o agravamento de complicações cardiovasculares. Métodos: Trata-se de uma revisão integrativa realizada entre agosto e novembro de 2023. As bases de dados utilizadas foram: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), National Library of Medicine and National Institutes of Health (PUBMED) e Biblioteca Virtual em Saúde (BVS). Os descritores foram “Heart Diseases”, “Cardiovascular complications”, “COVID-19”, “Treatment” e “SARS-CoV-2” e os operadores booleanos foram “AND”. Excluíram-se os estudos de revisão e foram incluídos artigos escritos entre 2020 e 2023, escritos em inglês e gratuitos. Resultados: Dos 19 artigos estudados, 7 abordaram tratamento medicamentoso, no qual houve melhora no quadro clínico e tempo de sobrevida. Os 12 artigos restantes relacionados à vacina mostram que o risco de complicações cardiovasculares é raro, com maior frequência em jovens homens. Considerações finais: Não se verificou ocorrências significativas de complicações cardiovasculares em pacientes que foram submetidos ao tratamento medicamento ou à vacina contra a doença, sendo ambas essenciais para o combate da doença.
Development of Basic Pencak Silat Techniques for High School Students
Authors: Wiguno Lokananta Teguh Hari , Kurniawan Ari Wibowo , Wahyudi Heri , Puspitasari Dianti Fera , Salamuddin Norlena 
Published: June 2024

Pencak silat is one of popular martial art originated from Indonesia that is learnt by students from various level. The learning process of pencak silat requires innovative media to help students learn it effectively. This study aims to develop an application-based learning media as a suitable solution to overcome problems related to PSHT martial arts learning material for the Persaudaraan Setia Hati Terate (PSHT) club at high schools. This study employed a research and development (R&D) methodology. The participants were 17 pencak silat student-athletes from the PSHT club or extracurricular program. Observations and interviews were conducted to collect the data. This research completed three expert validations, which include evaluations by coaching experts with an average score of 83.0%, PSHT material experts with an average score of 83.25%, and media experts with an average score of 97.5%. The overall product trial involved 17 student-athletes and was split into two phases: a small group trial with 5 participants, which achieved an 84.58% success rate, and a large group trial with 12 participants, which yielded an 80.90% success rate. Based on these results, the learning media for basic pencak silat techniques for PSHT student-athletes met valid standards and may be used without revision.
Improving industry system for compliance assessment of welding consumables in reliance on ensuring technological independence
Authors: Аралов Олег Васильевич , Вьюнов Сергей Иванович , Ишбулатов Тимур Рамилевич 
Published: June 2024

В условиях санкционных ограничений остро встает вопрос обеспечения российского рынка сварочных материалов, применяемых на опасных производственных объектах, включая магистральные трубопроводы, продукцией отечественного производства, а также расширения взаимодействия с производителями из стран, поддерживающих партнерские отношения с Россией. В этой связи система оценки соответствия сварочных материалов должна, с одной стороны, обеспечивать требуемое качество данного вида продукции, с другой – стимулировать привлечение добросовестных производителей. Целью настоящей статьи является анализ системы соответствия сварочных материалов, применяемых на объектах магистральных трубопроводов ПАО «Транснефть», с учетом решения задач по импортозамещению и обеспечению требуемого качества продукции в условиях переформатирования рынка. Авторами выполнен анализ производства сварочных материалов в России, проанализированы основные проблемные вопросы, связанные с оценкой соответствия и повышением качества данного вида продукции.
In the current conditions of sanction restrictions, there is an urgent problem of providing the Russian market of welding consumables used at hazardous production facilities, including main pipelines, with domestic products, as well as expanding the cooperation with manufacturers from countries that maintain partnerships with Russia. In this context, a compliance assessment system for welding consumables should, one the one hand, ensure the required quality of this type of products and, on the other hand, promote the attraction of bona fide manufacturers into the industry. The purpose of this paper is to analyze the compliance assessment system for welding consumables used at the main pipeline facilities of Transneft, taking into account the need to solve import substitution problems and to ensure the required product quality under the market reformatting conditions. The authors analyzed the production of welding consumables in Russia, studied the key problematic issues related to compliance assessment and improving the quality of this type of product.
THE INFLUENCE OF THE LEADERSHIP STYLE OF THE CHAIRMAN OF THE DPRD OF TANGERANG CITY ON THE PERFORMANCE OF LEGISLATIVE ORGANIZATIONS IN THE COVID-19 ERA
Authors: Yani W.A. William , Kadarisman Muh. , Satispi Evi , Samudra Azhari Aziz 
Published: June 2024

The pandemic period where coordination activities were limited to online meetings because of the fear of interacting face-to-face in the coordination process with related parties. Research Methods using quantitative methods. In collecting data, the author uses a questionnaire as a data collection tool. And using multiple linear regression. The research location is in the DPRD of Tangerang City organization. Based on the results of the study 1) There is an influence of policies on handling the Covid-19 pandemic on the performance of the DPRD of Tangerang City Organization. The value of the policy coefficient for handling the Covid 19 pandemic is 0.259, which is positive with the result of t count of 2.934 > t table (1.679) and a significance of t of 0.005 <0.05. 2) The value of the leadership style coefficient of the DPRD of Tangerang City chairman is 0.456, which is positive with the results of t count of 7.885 > t table (1.679) and a significance of t of 0.000 <0.05. That is, H2 is accepted. 3) The calculated F value obtained is 48.965 > F table (3.20) and the F significance obtained from the model is 0.000 less than 0.05. That is, H3 is accepted. Based on the results of the study, it can be concluded that the Leadership Style Variable of the Chairperson of the DPRD of Tangerang City can contribute an influence of 0.456 which is stronger than the Covid-19 Pandemic Handling Policy variable which only contributes 0.259. This means that the leadership style of the DPRD of Tangerang City Chairman has a greater impact on increasing the DPRD of Tangerang City Organizational Performance in 2020-2021.
Estimación de las contribuciones de los turistas para la sostenibilidad financiera del Parque Nacional Cotopaxi del Ecuador
Authors: Valle Álvarez Tatiana , Silva Ajila Diana , Valencia Nuñez Roberto 
Published: June 2024

El Ecuador enfrenta cambios de transformación productiva y reconoce como sector priorizado el turismo, el cual debe ser explotado y además está relacionado con la sostenibilidad de las áreas protegidas, las mismas que tienen recursos limitados. El presente artículo tiene como objetivo identificar si las contribuciones voluntarias de los turistas ayudan a la sostenibilidad financiera del Parque Nacional Cotopaxi del Ecuador. La investigación planea tres escenarios de sensibilidad para la sostenibilidad financiera, estructurados en base a estimaciones de gastos y fuentes de financiamiento incluyendo los aportes voluntarios. Al analizar los resultados se observa que se pueden cubrir los gastos del área protegida bajo un escenario óptimo considerando las aportaciones voluntarias como una fuente de financiamiento, cabe señalar que los factores relacionales sobresalientes son los convenios, la cooperación internacional, pero sin dejar de lado el aporte del Estado, ante todo se demuestra disponibilidad de aportación por parte del turista lo cual es importante para la conservación y sostenibilidad financiera del parque.
URL: https://revistas.uta.edu.ec/erevista/index.php/bcoyu/article/view/1016