bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features and outcomes of focal intimal disruption in acute type B intramural haematoma
Authors: Jung Joon Chul , Chang Hyoung Woo , Lee Jae Hang , Park Kay-Hyun 
Published: May 2024

Abstract

OBJECTIVES
A focal intimal disruption (FID) is a risk factor for adverse aorta-related events in patients with acute type B intramural haematoma. This study evaluated the impact of FIDs on overall survival with a selective intervention strategy for large or growing FIDs. Additionally, this study evaluated the risk factors associated with the growth of FIDs.

METHODS
This retrospective study included all consecutive patients admitted for acute type B intramural haematomas between November 2004 and April 2021. The primary outcome was overall survival. The secondary outcome was the cumulative incidence of composite aortic events and the growth of FIDs. The latter was calculated on centreline-reconstructed computed tomography images.

RESULTS
A total of 105 patients were included. A total of 106 FIDs were identified in 73 patients (73/105, 69.5%). The 1- and 5-year cumulative incidence rates of composite aortic events were 36.2% and 39.2%, respectively. The 1- and 5-year overall survival was 93.3% and 81.5%, respectively. Initial maximal aortic diameter and large FIDs during acute phase were significant risk factors for composite aortic events, but not risk factors for overall survival. The early appearance interval of an FID was a significant risk factor for growth of an FID.

CONCLUSIONS
With a selective intervention strategy for large or growing FIDs, the presence of large FIDs during the acute phase does not affect overall survival. The early appearance interval was associated with the growth of FIDs.
The reflective measurement model of adherence to non-pharmaceutical interventions (NPIs) in accordance with normalization process theory (NPT) in coherent and convenient social subgroups: PLS-SEM analysis
Authors: Pletikosa Pavic Magda , Pranic Shelly Melissa , Mastelic Tonci , Kljucevic Zeljko , Gotovac Majda , Savicevic Anamarija Jurcev , Kozina Tonci , Kozina Slavica 
Published: May 2024

Abstract

Background
Non-pharmaceutical interventions (NPIs) decrease COVID-19 transmission. Reliability and validity of adherence to NPIs in accordance with normalization process theory (NPT) in coherent and convenient social subgroups using reflective measurement model assessment has not been evaluated.

Methods
In February 2021, a sample of medical students and people with substance use disorders in treatment as coherent (based on continuous probability distribution) vs. convenient groups (based on convenience, not equal probability) composed of travellers and COVID-19 suspected persons from Split-Dalmatia County (SDC) (n = 656) in the Mediterranean completed self-administered surveys. Partial least squares structural equation modelling (PLS-SEM) was used to measure reflective model assessment of adherence to NPIs according to NPT.

Results
PLS-SEM reflective model assessment provided two-group specific factors in inverse relationships which determined adherence to NPIs with excellent goodness-of-fit [χ2 = 1.292, df = 1; P = 0.297, CFI = 1, TLI = 0.997, RMSEA = 0.011 (90% CI 0–0.105), RMSEA P = 0.604, SRMR = 0.008, Hoelter CN (α = 0.05) = 2322.757]. Significant negative factors covariance estimate (−0.716) revealed an inverse relationship between first (adherence to NPIs and internal locus of control (LoC) (0.640)) and second factor; young adulthood age (≤25) and highest level of education (1362). As the first factor increased the second tended to decrease. LoC is expected potential mechanism by which sex (MLsex = −0.017, SE = 0.007, P &lt; 0.016) and belonging to coherent subgroups (MLgroup = −0.008, SE = 0.003, P = 0.015) can produce indirect effect of adherence to NPIs.

Conclusions
Coherent subgroups had a more pronounced tendency toward integration of NPIs in everyday life. Group factors that facilitate the normalization were higher educated younger adults with a tendency toward external LoC.
Spectral decomposition of ground motions in New Zealand using the generalized inversion technique
Authors: Zhu Chuanbin , Bora Sanjay , Bradley Brendon A , Bindi Dino 
Published: May 2024

SUMMARY
To gain new insights into ground-motion phenomena in New Zealand (NZ), we apply the non-parametric generalized inversion technique (GIT) in the Fourier domain to isolate the systematic source, path, and site effects from 20 813 seismograms, recorded by 693 sensors at 439 unique locations, from 1200 shallow crustal events (Mw &gt; 3) during the period 2000–2021. From the inverted source spectra, we derive Brune's stress parameter, ∆σ, which is found to follow a lognormal distribution with a log10 standard deviation of 0.36 or equivalently 0.83 in natural log unit. ∆σ slightly increases with focal depth and is practically independent of earthquake size (i.e. self-similar), but displays a statistically significant spatial clustering. Based on the inverted attenuation, a trilinear geometric-spreading function, and a distance-dependent quality-factor Q(f) model are found to well describe the attenuation in NZ; though a single $Q( f )$ model is also obtained for the whole distance range: $Q( f ) = 149.1{f}^{0.62}$. Using the site response decomposed from GIT, we find that the soil classification scheme specified in NZ seismic code, NZS1170.5, has a limited capability in discerning the site-specific frequency-dependent amplification functions in comparison to a non-parametric clustering with the same number of discrete classes. The potential use of the spatial variation in source parameters from this GIT analysis in region-specific physics-based simulations is discussed.
Twelve more bulky genomes in the Polyneoptera: characterizing the Order Embioptera
Authors: Kelly Erin Taylor , Whittall Justen B , Poolprasert Pisit , Edgerly Janice S 
Published: May 2024

Abstract
Polyneopteran insects have relatively large genomes compared to holometabolous insects, which appear constrained by a threshold of 2 pg/1C DNA. This threshold may be due to costly complex development and higher energy demands. Genome sizes (GSs) are particularly bulky in various species of Orthoptera, reaching sizes up to 18.64 pg/1C DNA, however, recent analyses comparing insect GSs neglected the order Embioptera (webspinners). Our access to fresh specimens of 12 species from 6 of the 13 named taxonomic families provided a chance to determine if embiopterans also support bulky genomes. Flow cytometry results revealed that embiopteran GSs ranged from 2.41 to 7.56 pg/1C, similar to other polyneopterans. Based on previous studies reporting correlations with GS, we tested for correlations between GS and body length using independent contrasts. The ancestral state of the root was estimated at 4.57 pg/1C. A positive relationship was detected whereby larger-bodied webspinners displayed larger genomes, with female Antipaluria urichi (Saussure) (Clothodidae) having the largest genome at 7.56 pg/1C. This GS is approximately 3 times larger than the previously reported embiopteran GS of pg = 2.66 for a male Oligotoma saundersii (Westwood) (Oligotomidae). GS showed no consistent patterns of phylogenetic signal for Embioptera. The underlying causes for large genomes are briefly reviewed.
Accumulation of lipid droplets induced by Listeria monocytogenes in macrophages: implications for survival and evasion of innate immunity
Authors: Pereira-Dutra Filipe S , Souza Ellen K , Souza Tamyris S , Goltara-Gomes Taynná C , Ferraro-Moreira Felipe , Palhinha Lohanna , Cunha-Fernandes Tamires , Rajão Matheus A , Silva Adriana R , Bozza Patrícia T 
Published: May 2024

Abstract
Listeriosis, caused by Listeria monocytogenes (L.m.), poses a significant public health concern as one of the most severe foodborne diseases. The pathogenesis of L.m. involves critical steps such as phagosome rupture and escape upon internalization. Throughout infection, L.m. influences various host processes, including lipid metabolism pathways, yet the role of lipid droplets (LDs) remains unclear. Here, we reported a rapid, time-dependent increase in LD formation in macrophages induced by L.m. LD biogenesis was found to be dependent on L.m. viability and virulence genes, particularly on the activity of the pore-forming protein listeriolysin O (LLO). The prevention of LD formation by inhibiting diacylglycerol O-acyltransferase 1 (DGAT1) and cytosolic phospholipase A2 (cPLA2) significantly reduced intracellular bacterial survival, impaired prostaglandin E2 synthesis, and decreased interleukin-10 production. Additionally, inhibiting LD formation led to increased levels of tumor necrosis factor α and interferon β. Collectively, our data suggest a role for LDs in promoting L.m. cell survival and evasion within macrophages.
Transgenerational plasticity in salinity tolerance of rice: unraveling non-genetic phenotypic modifications and environmental influences
Authors: Aycan Murat , Nahar Lutfun , Baslam Marouane , Mitsui Toshiaki 
Published: May 2024

Abstract
Transgenerational plasticity in plants enables rapid adaptation to environmental changes, allowing organisms and their offspring to adapt to the environment without altering their underlying DNA. In this study, we investigated the transgenerational plasticity in salinity tolerance of rice plants using a reciprocal transplant experimental strategy. Our aim was to assess whether non-genetic environment-induced phenotypic modifications and transgenerational salinity affect the salinity tolerance of progeny while excluding nuclear genomic factors for two generations. Using salt-tolerant and salt-sensitive rice genotypes, we observed that the parentally salt-stressed salt-sensitive genotype displayed greater growth performance, photosynthetic activity, yield performance, and transcriptional responses than the parentally non-stressed salt-sensitive plants under salt stress conditions. Surprisingly, salt stress-exposed salt-tolerant progeny did not exhibit as much salinity tolerance as salt stress-exposed salt-sensitive progeny under salt stress. Our findings indicate that the phenotypes of offspring plants differed based on the environment experienced by their ancestors, resulting in heritable transgenerational phenotypic modifications in salt-sensitive genotypes via maternal effects. These results elucidated the mechanisms underlying transgenerational plasticity in salinity tolerance, providing valuable insights into how plants respond to changing environmental conditions.
Exercise-Induced Pulmonary Hemorrhage in a Non-Athletic Child: Implications for Military Recruits
Authors: Oliver Amanda , Boster Joshua , Warren Whittney , Welsh Sebastian 
Published: May 2024

ABSTRACT
Hemoptysis is a rare presenting symptom in pediatric and young adult patients with a highly variable outcome ranging from an isolated mild occurrence to severe illness and death. Exercise-induced pulmonary hemorrhage (EIPH) has several reports in adult literature but has not previously been reported in pediatric patients. A 12-year-old female with a history of trisomy X (47, XXX), obesity, depression, anxiety, and obstructive sleep apnea presented to the pediatric pulmonology clinic after several episodes of hemoptysis. Spirometry, imaging, and laboratory evaluation for autoimmune vasculitides and other causes associated with pediatric hemoptysis did not reveal an etiology for the hemoptysis. A combined bronchoscopy with pediatric and adult providers revealed no airway lesions or sources of bleeding. EIPH is a diagnosis of exclusion. This patient was diagnosed with EIPH and had spontaneous resolution with improved fitness. Many military training and service activities are similar to those reported with EIPH. Trainees with various levels of aerobic fitness are at risk of developing EIPH. The hemoptysis evaluation is important for military providers given the range of severity in presentations, even though it is a rare occurrence. In addition to a novel presentation of EIPH, this case demonstrates the value of collaboration between pediatric and adult specialists in the Military Health System (MHS). Military care providers should be aware of this rare phenomenon in service members and trainees who are at risk during maximal aerobic effort.
The effect of reionization on direct measurements of the mean free path
Authors: Roth Joshua T , D’Aloisio Anson , Cain Christopher , Wilson Bayu , Zhu Yongda , Becker George D 
Published: May 2024

ABSTRACT
Recent measurements of the ionizing photon mean free path (MFP) based on composite quasar spectra may point to reionization ending at z &lt; 6. These measurements are challenging because they rely on assumptions about the proximity zones of the quasars. For example, some quasars might have been close to neutral patches where reionization was still ongoing (‘neutral islands’), and it is unclear how they would affect the measurements. We address this question with mock MFP measurements from radiative transfer simulations. We find that, even in the presence of neutral islands, our mock MFP measurements agree to within $30~{{\ \rm per\ cent}}$ with the true spatially averaged MFP in our simulations, which includes opacity from both the ionized medium and the islands. The inferred MFP is sensitive at the $\lt ~50~{{\ \rm per\ cent}}$ level to assumptions about quasar environments and lifetimes for realistic models. We demonstrate that future analyses with improved data may require explicitly modelling the effects of neutral islands on the composite spectra, and we outline a method for doing this. Lastly, we quantify the effects of neutral islands on Lyman-series transmission, which has been modelled with optically thin simulations in previous MFP analyses. Neutral islands can suppress transmission at λrest &lt; 912 Å significantly, up to a factor of 2 for zqso = 6 in a plausible reionization scenario, owing to absorption by many closely spaced lines as quasar light redshifts into resonance. However, the suppression is almost entirely degenerate with the spectrum normalization and thus does not significantly bias the inferred MFP.
CURLING – I. The influence of point-like image approximation on the outcomes of cluster strong lens modelling
Authors: Xie Yushan , Shan Huanyuan , Li Nan , Li Ran , Jullo Eric , Su Chen , Cao Xiaoyue , Kneib Jean-Paul , Acebron Ana , He Mengfan , Yao Ji , Wang Chunxiang , Li Jiadong , Li Yin 
Published: May 2024

ABSTRACT
Cluster-scale strong lensing is a powerful tool for exploring the properties of dark matter and constraining cosmological models. However, due to the complex parameter space, pixelized strong lens modelling in galaxy clusters is computationally expensive, leading to the point-source approximation of strongly lensed extended images, potentially introducing systematic biases. Herein, as the first paper of the ClUsteR strong Lens modelIng for the Next-Generation observations (CURLING) program, we use lensing ray-tracing simulations to quantify the biases and uncertainties arising from the point-like image approximation for JWST-like observations. Our results indicate that the approximation works well for reconstructing the total cluster mass distribution, but can bias the magnification measurements near critical curves and the constraints on the cosmological parameters, the total matter density of the universe Ωm, and dark energy equation of state parameter w. To mitigate the biases, we propose incorporating the extended surface brightness distribution of lensed sources into the modelling. This approach reduces the bias in magnification from 46.2 per cent to 0.09 per cent for μ ∼ 1000. Furthermore, the median values of cosmological parameters align more closely with the fiducial model. In addition to the improved accuracy, we also demonstrate that the constraining power can be substantially enhanced. In conclusion, it is necessary to model cluster-scale strong lenses with pixelized multiple images, especially for estimating the intrinsic luminosity of highly magnified sources and accurate cosmography in the era of high-precision observations.
Local primordial non-Gaussianity from the large-scale clustering of photometric DESI luminous red galaxies
Authors: Rezaie Mehdi , Ross Ashley J , Seo Hee-Jong , Kong Hui , Porredon Anna , Samushia Lado , Chaussidon Edmond , Krolewski Alex , de Mattia Arnaud , Beutler Florian , Aguilar Jessica Nicole , Ahlen Steven , Alam Shadab , Avila Santiago , Bahr-Kalus Benedict , Bermejo-Climent Jose , Brooks David , Claybaugh Todd , Cole Shaun , Dawson Kyle , de la Macorra Axel , Doel Peter , Font-Ribera Andreu , Forero-Romero Jaime E , Gontcho Satya Gontcho A , Guy Julien , Honscheid Klaus , Huterer Dragan , Kisner Theodore , Landriau Martin , Levi Michael , Manera Marc , Meisner Aaron , Miquel Ramon , Mueller Eva-Maria , Myers Adam , Newman Jeffrey A , Nie Jundan , Palanque-Delabrouille Nathalie , Percival Will , Poppett Claire , Rossi Graziano , Sanchez Eusebio , Schubnell Michael , Tarlé Gregory , Weaver Benjamin Alan , Yèche Christophe , Zhou Zhimin , Zou Hu 
Published: May 2024

ABSTRACT
We use angular clustering of luminous red galaxies from the Dark Energy Spectroscopic Instrument (DESI) imaging surveys to constrain the local primordial non-Gaussianity parameter fNL. Our sample comprises over 12 million targets, covering 14 000 deg2 of the sky, with redshifts in the range 0.2 &lt; z &lt; 1.35. We identify Galactic extinction, survey depth, and astronomical seeing as the primary sources of systematic error, and employ linear regression and artificial neural networks to alleviate non-cosmological excess clustering on large scales. Our methods are tested against simulations with and without fNL and systematics, showing superior performance of the neural network treatment. The neural network with a set of nine imaging property maps passes our systematic null test criteria, and is chosen as the fiducial treatment. Assuming the universality relation, we find $f_{\rm NL} = 34^{+24(+50)}_{-44(-73)}$ at 68 per cent (95 per cent) confidence. We apply a series of robustness tests (e.g. cuts on imaging, declination, or scales used) that show consistency in the obtained constraints. We study how the regression method biases the measured angular power spectrum and degrades the fNL constraining power. The use of the nine maps more than doubles the uncertainty compared to using only the three primary maps in the regression. Our results thus motivate the development of more efficient methods that avoid overcorrection, protect large-scale clustering information, and preserve constraining power. Additionally, our results encourage further studies of fNL with DESI spectroscopic samples, where the inclusion of 3D clustering modes should help separate imaging systematics and lessen the degradation in the fNL uncertainty.
Transcriptional landscape and dynamics involved in sugar and acid accumulation during apple fruit development
Authors: Li Baiyun , Zhu Lingcheng , Yang Nanxiang , Qu Shengtao , Cao Wenjing , Ma Wenfang , Wei Xiaoyu , Ma Baiquan , Ma Fengwang , Fu Aigen , Li Mingjun 
Published: May 2024

Abstract
In fleshy fruit, sugars and acids are central components of fruit flavor and quality. To date, the mechanisms underlying transcriptional regulation of sugar and acid during fruit development remain largely unknown. Here, we combined ATAC-seq with RNA-seq to investigate the genome-wide chromatin accessibility and to identify putative transcription factors related to sugar and acid accumulation during apple (Malus domestica) fruit development. By integrating the differentially accessible regions and differentially expressed genes, we generated a global data set of promoter–accessibility and expression-increased genes. Using this strategy, we constructed a transcriptional regulatory network enabling screening for key transcription factors and target genes involved in sugar and acid accumulation. Among these transcription factors, 5 fruit-specific DNA binding with one finger genes were selected to confirm their regulatory effects, and our results showed that they could affect sugar or acid concentration by regulating the expression of sugar or acid metabolism-related genes in apple fruits. Our transcriptional regulatory network provides a suitable platform to identify candidate genes that control sugar and acid accumulation. Meanwhile, our data set will aid in analyzing other characteristics of apple fruit that have not been illuminated previously. Overall, these findings support a better understanding of the regulatory dynamics during apple fruit development and lay a foundation for quality improvement of apple.
From pole to pole, life-long research of sleep in extreme environments
Authors: Buguet Alain G C 
Published: May 2024

Abstract
In November 1965, Michel Jouvet accepted me into his laboratory in Lyon as a medical student at a time when sleep research was an adventure. After 4 years of investigations in cats, I obtained my medical doctorate. Being a military physician, I was posted to Antarctica for wintering over and was initiated by Jean Rivolier into the psychology of small isolated human groups. I recorded 180 polysomnographic (PSG) nights in eight of my companions. This was my first contribution to research on human sleep under extreme environments and conditions. I then entered René Hénane’s military thermophysiology laboratory, where I analyzed thermal exchanges during human sleep in the heat. Back to the cold, I spent 2 years in Canada and analyzed sleep during the Arctic winter under the direction of Manny W. Radomski, who headed the Defense and Civil Institute of Environmental Medicine and judged my PhD dissertation along with my first two mentors. Throughout my career, I worked in collaboration with Manny Radomski under the auspices of the Franco-Canadian Accord for Defence Research. We studied sleep and exercise, sleep deprivation, and recovery with and without chemical help. He also gave me support during several investigations in Africa. There, I studied normal sleep under various tropical climates (warm and dry in Niger, warm and humid in Côte d’Ivoire and Congo, temperate mid-mountain in Angola). I determined that human African trypanosomiasis, the ravaging sleeping sickness or tsetse disease, is not a hypersomnia, but a disorder of circadian rhythms, notably in the sleep–wake cycle.
SecYEG-mediated translocation in a model synthetic cell
Authors: Schoenmakers Ludo L J , den Uijl Max J , Postma Jelle L , van den Akker Tim A P , Huck Wilhelm T S , Driessen Arnold J M 
Published: May 2024

Abstract
Giant unilamellar vesicles (GUVs) provide a powerful model compartment for synthetic cells. However, a key challenge is the incorporation of membrane proteins that allow for transport, energy transduction, compartment growth and division. Here, we have successfully incorporated the membrane protein complex SecYEG—the key bacterial translocase that is essential for the incorporation of newly synthesized membrane proteins—in GUVs. Our method consists of fusion of small unilamellar vesicles containing reconstituted SecYEG into GUVs, thereby forming SecGUVs. These are suitable for large-scale experiments while maintaining a high protein:lipid ratio. We demonstrate that incorporation of SecYEG into GUVs does not inhibit its translocation efficiency. Robust membrane protein functionalized proteo-GUVs are promising and flexible compartments for use in the formation and growth of synthetic cells.
The Society of Behavioral Medicine urges passage of the PLANT (Peas, Legumes, And Nuts Today) Act
Authors: Bell Brooke M , Battaglia Kyra , Wasim Natasha , Marquez Alejandra S , Tichenor Blackstone Nicole 
Published: May 2024

Abstract
Current US diets negatively impact human health and the environment, while shifting toward increased intake of plant-based foods could mitigate these issues. Current food policies exacerbate these problems, necessitating a reevaluation and the implementation of new policies. The Society of Behavioral Medicine urges legislators to support the PLANT Act (H.R.5023), which would enhance production, research, and development of plant-based foods and address both health and environmental concerns.