bluuebunny/crossref_metadata_2025_split huggingface dataset:
Traumatic Pseudoaneurysm of the Cervical Carotid Artery: The Value of Arteriography
Authors: Applegate Laura Jones , Pritz Michael B. , Pribram Henry F. W. 
Published: April 2011

Abstract
A patient who sustained a gunshot wound to the neck and subsequent blunt trauma is presented. No angiogram was performed after the initial injury. Subsequently, the patient developed a cerebral embolus from a thrombus dislodged from a pseudoaneurysm of the cervical carotid artery, resulting in complete occlusion of the distal internal carotid artery. After antiplatelet therapy, the distal internal carotid artery recanalized. and the pseudoaneurysm occluded spontaneously. We stress the need for the use of arteriography in the initial evaluation of penetrating injuries to the neck and the utility of repeated arteriograms for further treatment planning as these traumatic lesions can change with time.
Congenital Aneurysmal Dilatation of the Petrous-Cavernous Carotid Artery and Vertebral Basilar Junction in a Child
Authors: Guha Abhijit , Montanera Walter , Hoffman Harold J. 
Published: April 2011

Abstract
The occurrence of intracranial aneurysms in the pediatric population is a rare phenomenon. An unusual case of aneurysmal dilatation of both petrous and cavernous carotid arteries and the vertebral-basilar junction in a child is presented. The underlying etiology, natural history, and possible modes of management are reviewed and discussed.
Intraneural Synovial Cyst of the Peroneal Nerve: Report of Two Cases and Review of The Literature
Authors: Nucci Francesco , Artico Marco , Santoro Antonio , Bardella Lia , Delfini Roberto , Bosco Sandro , Palma Lucio 
Published: April 2011

Abstract
We report two cases of peroneal nerve compression caused by an intraneural synovial cyst and discuss the pathogenesis. clinical and electrophysiological diagnosis, and treatment of these uncommon lesions in the light of the salient published work on the subject.
Anticopper Treatment Inhibits Pseudopodial Protrusion and the Invasive Spread of 9L Gliosarcoma Cells in the Rat Brain
Authors: Brem Steven , Tsanaclis Ana Maria C. , Zagzag David 
Published: April 2011

Abstract
The copper ion, a cofactor of angiogenesis, is sequestered in human brain tumors and the adjacent brain. The invasive spread of neoplastic cells has been linked to angiogenesis and involves similar mechanisms of migration and tumormatrix interaction. In this report, copper depletion inhibited the infiltrative spread of the normally invasive 9L gliosarcoma. Twenty male Fischer 344 rats were each injected with 1 x 1059L cells; 10 rats were treated with a lowcopper diet and penicillamine. In the normocupremic control rats, a “diffuse” invasive pattern was observed in all 10 animals. In the hypocupremic group, a “nodular” pattern, with a discrete border between tumor and brain, was found in 7 of 10 rats (P&lt; 0.01). In a second experiment, the brains of 16 tumor-bearing rats were studied by electron microscopy. In the 8 normocupremic control rats, cytoplasmic extensions and pseudopodial protrusions, cytological markers of invasive cells, were prominent at the tumor-brain interface. In striking contrast, pseudopodia were absent along the border of the tumors in the 8 hypocupremic rats. These findings suggest a biological role of copper in the neoplastic spread of brain tumor cells. Pharmacological and metabolic alteration of the cellular microenvironment to inhibit invasiveness represents a novel therapeutic approach, especially for tumors of the brain in which malignancy is a function of regional invasiveness.
Cerebral Venous and Sagittal Sinus Thrombosis after Transcallosal Removal of a Colloid Cyst of the Third Ventricle
Authors: Garrido Eddy , Fahs Gerald R. 
Published: April 2011

Abstract
The authors report a case of cortical vein and sagittal sinus thrombosis after a transcallosal removal of a colloid cyst of the third ventricle. Thirty-six hours after the operation, the patient developed focal seizures: after progressive deterioration. he died on the sixth postoperative day. At the autopsy, a venous hemorrhagic infarct in the right frontoparietal area and fresh thrombus occluding the sagittal sinus and cortical veins were found. The mechanism of cortical vein and sinus thrombosis subsequent to this procedure is discussed, and suggestions are made to prevent this serious complication.
Operative Treatment of Intracranial Epidermoid Cysts and Cholesterol Granulomas: Report of 21 Cases
Authors: Altschuler Eric M. , Jungreis Charles A. , Sekhar Laligam N. , Jannetta Peter J. , Sheptak Peter E. 
Published: April 2011

Abstract
Thirteen patients had operations to remove intracranial epidermoid cysts, and long-term follow-up was obtained. Total or nearly total tumor and capsule removal was accomplished in 7 patients during the initial operation. This group required no additional operations. The other 6 underwent subtotal tumor removal and required multiple operations for symptomatic tumor recurrence. This latter group had a poorer neurological outcome. We conclude that initial total or near-total tumor resection is highly desirable in treating intracranial epidermoid cysts, particularly in physiologically young individuals. Five patients were followed after operations to remove pure cholesterol granulomas of the petroclival bone, and 3 additional patients were followed after operations to remove tumors with combined histopathological features of both an epidermoid cyst and cholesterol granuloma. Four patients with some component of a cholesterol granuloma had concurrent middle ear infections, and 4 did not. Intracranial subtotal excision and drainage of these lesions was the initial operative management in 7 patients. 5 of whom have required multiple operations for symptomatic tumor recurrence. Therefore, we conclude that subtotal excisional procedures for tumors with histopathological features of cholesterol granulomas are not usually successful in establishing long-term cures. Total excision, as recommended for epidermoid cysts, tumors frequently confused with cholesterol granulomas when occupying the petroclival region, may be warranted for these tumors as well. We postulate that when a congenital epidermoid cyst occurs in the petroclival bone, it may incite a local inflammatory reaction, producing lesions which have the histological features of both epidermoid cysts and cholesterol granulomas.
Chronic Encapsulated Intracerebral Hematoma Associated with Cavernous Angioma: A Case Report
Authors: Murakami Shigeyuki , Sotsu Masahiro , Morooka Satoru , Suzuki Takashi 
Published: April 2011

Abstract
The case of a patient with a chronic encapsulated intracerebral hematoma associated with a cavernous angioma is reported. In spite of a huge space-occupying lesion in the frontal lobe, our patient showed no focal neurological deficit. The clinical picture suggested a slowly growing brain tumor. Intraoperative findings revealed a liquefied intracerebral hematoma with a thick capsule. Pathological investigations demonstrated a capsule rich in neovascularity with a cavernous angioma attached to it. It is presumed that initial bleeding from the cavernous angioma encouraged capsule formation similar to the membrane of chronic subdural hematomas and that repeated bleeding from the capillaries of the capsule allowed the expansion of the hematoma.
Cerebral Granuloma and Meningitis Caused by Candida albicans: Useful Monitoring of Mannan Antigen in Cerebrospinal Fluid
Authors: Ikeda Kiyonobu , Yamashita Junkoh , Fujisawa Hironori , Fujita Shi-ichi 
Published: April 2011

Abstract
The authors report the case of a previously healthy patient who had recurrent cerebral granulomas and meningitis caused by Candida albicans 15 years after the first onset. A combination of external drainage of cerebrospinal fluid (CSF) and intraventricular and intravenous chemotherapy with antifungal agents resulted in a favorable outcome. Investigation of this patient revealed no immunological dysfunction, lymphoproliferative disorder, or candidicidal defect of peripheral blood leukocytes. Sequential measurement of Candida mannan antigen in CSF was useful for establishing the early diagnosis of cerebral candidiasis and for judging the effect of our antifungal chemotherapy. In determining the surgical indications and timing of placement of a ventriculoperitoneal or ventriculoatrial shunt for meningitis subsequent to hydrocephalus after candidal infection, it is better to confirm normal concentrations of the mannan antigen in the CSF repeatedly for more than a week and to determine that cultures of the CSF are negative for Candida albicans.
Surgical Approaches to the Cavernous Sinus: A Microsurgical Study
Authors: Inoue Tooru , Rhoton Albert L. , Theele Dan , Barry Margaret E. 
Published: April 2011

Abstract
The surgical approaches to the cavernous sinus were examined in 50 adult cadaveric cavernous sinuses using magnification of ×3 to ×40. The following approaches were examined: 1) the superior intradural approach directed through a frontotemporal craniotomy and the roof of the cavernous sinus: 2) the superior intradural approach combined with an extradural approach for removing the anterior clinoid process and unroofing the optic canal and orbit; 3) the superomedial approach directed through a supraorbital craniotomy and subfrontal exposure to the wall of the sinus adjacent to the pituitary gland; 4) the lateral intradural approach directed below the temporal lobe to the lateral wall of the sinus; 5) the lateral extradural approach for exposure of the internal carotid artery in the floor of the middle cranial fossa proximal to the sinus; 6) the combined lateral and inferolateral approach, in which the infratemporal fossa was opened and the full course of the petrous carotid artery and the lateral wall of the sinus were exposed and; 7) the inferomedial approach, in which the medial wall of the sinus was exposed by the transnasal-transsphenoidal route. It was clear that a single approach was not capable of providing access to all parts of the sinus. The intracavernous structures best exposed by each route are reviewed. The osseous relationships in the region were examined in dry skulls. Anatomic variants important in exposing the cavernous sinus are reviewed.
Infection of the Intervertebral Disc Space after Placement of a Percutaneous Lumboperitoneal Shunt for Benign Intracranial Hypertension
Authors: Cabezudo Jose M. , Olabe Javier , Bacci Fernando 
Published: April 2011

Abstract
The authors report the case of 22-year-old woman who developed a disc space infection after percutaneous placement of a lumboperitoneal shunt for benign intracranial hypertension.
Two Cases of Giant Serpentine Aneurysm
Authors: Kumabe Toshihiro , Kaneko Uichi , Ishibashi Takao , Kaneko Kou , Uchigasaki Shin'ya 
Published: April 2011

Abstract
Giant serpentine aneurysm (GSA) is an entity defined on radiological and pathological grounds as a giant, partially thrombosed aneurysm containing tortuous vascular channels. We have had the opportunity to study two patients with GSAs, which has allowed for a complete comparative anatomical and radiological study. This report emphasizes the etiology of the GSAs. Twenty-two patients with GSAs have been reported in the literature, of which pathological studies were done in 10. In most of these, the aneurysm was found to be filled with an organized thrombus, but in our patients the aneurysm was filled with relatively new clot. The aneurysm enlarged and a change in the tortuous vascular channel was observed over a period of 1 year in the first patient, whereas a globoid aneurysm developed into a GSA in the brief period of just 2 weeks in the second patient. This rapid transformation of a globoid aneurysm into a GSA is of particular interest when the etiology of GSAs is considered. Our patients therefore shed some interesting light on the possible pathophysiology of GSAs. That is, the bloodstream may change dynamically in a giant aneurysm and may become a serpentine channel under conditions that lead to a “Coanda effect.”
Carcinoma Metastatic to a Cerebellar Vascular Malformation: Case Report
Authors: Greene George M. , Hart Michael N. , Poor Marshall M. , Loftus Christopher M. 
Published: April 2011

Abstract
A 73-year-old woman with a spontaneous intracerebellar hemorrhage was seen and was found to have metastatic adenocarcinoma within a vascular malformation. There was no evidence of other metastatic disease. The association of these two lesions is uncommon and has rarely been reported. The rich vascularity of the malformation may explain the hematogenous deposition of metastatic neoplasm at this site.
Loss of Vision after Transsphenoidal Surgery
Authors: Barrow Daniel L. , Tindall George T. 
Published: April 2011

Abstract
Eleven patients who experienced significant loss of vision after transsphenoidal surgery are reported on. The mechanisms involved in these visual complications include direct injury or devascularization of the optic apparatus, fracture of the orbit, postoperative hematoma, cerebral vasospasm, and prolapse of the optic chiasm into an empty sella. Factors that may increase the risk of visual complications include the presence of a pituitary macroadenoma, previous visual impairment, a “bottleneck” or dumbbell-shaped tumor, previous surgery and/or radiation therapy, and, possibly, use of a lumbar subarachnoid catheter during operation. A practical approach to the management and avoidance of these complications is presented.
Cotrel-Dubousset Instrumentation for the Treatment of Thoracolumbar Fractures
Authors: Moreland Douglas B. , Egnatchik James G. , Bennett Gregory J. 
Published: April 2011

Abstract
Cotrel-Dubousset instrumentation (CDI) was introduced in 1984 primarily for the treatment of scoliosis. The applications of this unique and versatile system have expanded to other diseases of the spine. Thoracolumbar fractures are a common management problem for which the device seems to be well suited. We review our results of 15 patients with unstable thoracolumbar fractures treated with CDI at an average of 24 months‘ follow-up. The results are promising and compare favorably with other forms of surgical and medical management. Postoperatively, there was a loss of 2° in the angle of deformity and 0.9 mm of vertebral body displacement. Incomplete neurological injuries improved one or more Frankel grades in 75% of our patients. There were three complications (20%). CDI offers theoretical advantages over Harrington instrumentation and conservative (nonoperative) management. The use of CDI in the treatment of unstable thoracolumbar fractures is endorsed by these results.
The Risk and Efficacy of Anticoagulant Therapy in the Treatment of Thromboembolic Complications in Patients with Primary Malignant Brain Tumors
Authors: Altschuler Eric , Moosa Hans , Selker Robert G. , Vertosick Frank T. 
Published: April 2011

Abstract
Twenty-three patients with malignant glial neoplasms were treated with anticoagulant therapy for thromboembolic complications. Fifteen patients had deep vein thrombosis alone, and 8 patients had both deep vein thrombosis and pulmonary embolism. Serum prothrombin times were maintained at 1.25 times control for an average of 5.8 months per patient, for a total patient exposure to warfarin therapy of 132 patient-months (11 patient-years). Only 1 patient suffered a recurrent pulmonary embolism, and this occurred during an episode of gastrointestinal bleeding, when anticoagulant therapy had to be discontinued prematurely. All patients were followed with serial computed tomographic or magnetic resonance imaging scans, and no patient showed radiographic evidence of intratumoral hemorrhage either during or after warfarin therapy. One patient, who died from a large recurrent glioblastoma, was found at autopsy to have scattered foci of intratumoral hemorrhage. This series, together with a review of the available literature, suggests that oral anticoagulant therapy is both a safe and effective means of treating thromboembolic complications in patients with residual malignant glial tumors.
Changing Concepts in Spinal Epidural Abscess: A Report of 29 Cases
Authors: Del Curling O. , Gower David J. , McWhorter Joe M. 
Published: April 2011

Abstract
A review of our recent experience with spinal epidural abscess (SEA) reveals several important changing concepts in diagnosis, etiology, management, and outcome. All cases of SEA seen by our service from August 1975 to July 1989 were reviewed retrospectively, and 29 patients were identified (19 men and 10 women, aged 13-78 years). Abscesses were located in the lumbar (n = 21), thoracic (n = 7), and cervical (n = 1) epidural spaces. Gram-positive organisms were the infectious agent in 72% of the cases, and Staphyloccus aureus was the sole agent in 45% other agents were Gram-negative aerobes (n = 5), a Gram-negative anaerobe (n = 1), Mycobacterium tuberculosis(n = 1), and Sporotrichum schenckii(n = 1), the last occurring in a young woman with acquired immune deficiency syndrome. Seventeen patients had concomitant extraspinal infections. Diagnosis was confirmed by myelography, computed tomography, or magnetic resonance imaging. All patients underwent operative decompression and debridement; 2 required a second procedure for persistent infection. The most common operative findings were pus and granulation tissue in the epidural space (52%); the preoperative course correlated poorly with operative findings. The wound was closed primarily in 84% of cases. Postoperative intravenous antibiotic courses for the bacterial abscesses ranged from 1.5 to 6 weeks (median, 2 weeks), followed by antibiotics given orally for 0 to 6 weeks. Two patients died perioperatively. Neurological outcome was good in 21 patients and fair in 6 (mean follow-up, 1.4 years). Over the last 50 years the spectrum of organisms causing SEA has broadened, and the distinction between acute and chronic SEAs has minimal clinical significance. In addition, magnetic resonance imaging has come to have an adjunctive diagnostic role. Treatment by operative debridement, primary wound closure, and short courses of antibiotics given intravenously and orally has a consistently good result, and prognosis has markedly improved.
An Extreme Lateral Approach to Intradural Lesions of the Cervical Spine and Foramen Magnum
Authors: Sen Chandra N. , Sekhar Laligam N. 
Published: April 2011

Abstract
Meningiomas and neurofibromas are the most common intradural extramedullary tumors of the foramen magnum and cervical spine. Many of these tumors are located ventral or ventrolateral to the spinal cord and medulla. Posterior approaches, although adequate for the management of most of these tumors, can sometimes result in incomplete removal of the tumor and exacerbation of the neurological deficits. Although the transoral and transcervical approaches provide a direct route to the tumor, the exposure of the lateral margins in the case of large tumors is inadequate. In addition, because of the removal of vertebral bodies, subsequent fusion may be necessary. In the present report, an extreme lateral approach to the foramen magnum and cervical spine for the removal of intradural tumors is described. The approach provides a lateral exposure of the tumor-cord/stem interface, thus permitting safe dissection without retraction of the cord. The entire longitudinal and lateral extent of the tumor and also its extradural extension can be can be managed by this approach. This approach can be considered in such a group of patients harboring entirely ventral or recurrent tumors for which the conventional posterior approach has failed. Six patients who underwent this procedure are described to illustrate its application.
Histological Changes in Glioblastoma after Intratumoral Injection of Autologous Lymphocytes and Human Lymphoblastoid Interferon
Authors: Vaquero Jesùs , Coca Santiago , Oya Santiago , Martinez Roberto , Regidor Carmen , Barbolla Luz , Salazar Francisco G. , Ramiro Josefa 
Published: April 2011

Abstract
Seven glioblastomas were studied between 1 and 6 months after intratumoral injection of autologous lymphocytes and human lymphoblastoid interferon. Morphological study showed a great number of lymphocytes within the tumor tissue, and interactions between lymphocytes and glioblastoma cells, suggesting a killing phenomenon. These data support the potential usefulness of adoptive immunotherapy in patients with glioblastoma by means of intratumoral administration of activated lymphoid cells.
Acute Spinal Intradural Extramedullary Hematoma: A Nonsurgical Approach for Spinal Cord Decompression
Authors: Schwerdtfeger Karsten , Caspar Wolfhard , Alloussi Schanas , Strowitzki Martin , Loew Friedrich 
Published: April 2011

Abstract
The authors present the case of a 60-year old man with a spontaneous spinal intradural hematoma in the thoracic and lumbar region, which was caused by anticoagulant therapy and led to a severe progressive transverse lesion. After substitution of coagulation factors, a small catheter was inserted into the subarachnoid space via a lumbar puncture. By alternating irrigation and suction removal of the blood clot, restoration of the cerebrospinal fluid passage was possible along with a marked improvement in the neurological deficits. At 8 months' follow-up, the patient had completely recovered from the severe paraparesis and bladder dysfunction.
The Frequency-Dependent Behavior of Cerebral Autoregulation
Authors: Giller Cole A. 
Published: April 2011

Abstract
Cerebral autoregulation is a complex physiological process composed of both fast and slow components that may respond differently to different rates and patterns of blood pressure variation. To assess the temporal nature of autoregulation, transcranial Doppler velocity recordings of the middle cerebral artery obtained over prolonged periods were compared with blood pressure recordings in 5 patients without cerebral disease and in 13 patients with intracranial pathological changes. Correlations between the velocity and pressure wave forms at various frequencies of variation were measured with systems analysis techniques. Patients with aneurysmal subarachnoid hemorrhage had high correlations indicating pressure-dependent flow and impaired autoregulation. Patients without cerebral disease had significantly lower correlations (P&lt;0.01), indicating intact autoregulation. Examples of increasing correlations and correlations at new frequencies emerging as the clinical condition worsened are given. These preliminary examples suggest that the application of systems analysis techniques to velocity and pressure data allow measurement of the temporal nature of cerebral autoregulation.