bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Brain Networks in Toddlers with Autism Spectrum Disorder
Authors: Zuo Xi-Nian , Zhang Gongwei , Zhou Liwei , Nie Jingxin , Wang Xin , Han Junrong , Wu Hang , Zhang Xinyu , Yang Longyu , Liu Yunhe , Liao Qianyi , Li Peng , Zhao Cailei , Zhou Zhenhui , Zhou Jiaxiu , Qin Pengmin , Weng Xuchu 
Published: May 2024

Abstract

As early as 18-24 months, self-processing has been reported abnormal in autism spectrum disorder (ASD), echoing a key period for the emergence of self-awareness. However, the neural mechanisms underlying this phenomenon remains unclear. The self-processing was supposed integrating three nested levels: the interoceptive-self which represents bodily internal state, the exteroceptive-self which links the internal and external environment and marks a key step in self-awareness development, the mental-self which represents the mental world built on the abstract relationship between the internal and external environment. Therefore, we assumed that ASD may show abnormal exteroceptive-self from 18-24 months and then develop the disorders of mental-self with their growing. To test this hypothesis, resting-state functional magnetic resonance imaging data from both ASD and typically developing controls (TDC) were collected and divided into two age groups: 18-24 months and 25-48 months. In ASD, functional connectivity revealed hyperconnectivity within exteroceptive-self network; graph theory analysis revealed atypical nodal topological properties in both exteroceptive- and mental-self network. Based on these findings, a support vector machine (SVM) model was trained to distinguish ASD from TDC for each age groups, and then validated with independent datasets. The SVM models achieved accuracy rates of 88.2% (training) and 75% (testing) for the 18-24 months group, and 86.7% (training) and 84.6% (testing) for the 25-48 months group while SVM models based on the non-self-related brain regions cannot achieve similar accuracy. These findings disclose the abnormal information processing within self-network in brains of toddlers with ASD, and provide potential neuroimaging markers for its early detection and future translation.
A 2D Zn-MOF with Oxygen Functional Sites as An Efficient Luminescent Sensor for Detecting Cr2O72− in Water Media and HEPES Biological Buffer Solution
Authors: Niu Xue-Li , Yang Hua , Kong Lingqian , Dou Jian-Min , Wu Qian 
Published: May 2024

Abstract

Efficient detection of toxic heavy metal anions Cr2O72− residue in water media is of great significance due to its severe damage to ecosystem and human health. Herein, a new 2D (two-dimensional) luminescent metal–organic frameworks (MOFs) {[Zn2(bmida)(phen)]·H2O}n (abbr. Zn-MOF) (1,10-phen = 1,10-phenanthroline, H4bmida = N-(phosphonomethyl)iminodiacetic acid) with rich oxygen functional sites was constructed and structurally characterized. Notably, this Zn-MOF as an efficient luminescent sensor can detect Cr2O72− both in water media and HEPES biological buffer solution with high selectivity and sensitivity, and good cyclic stability. The corresponding detection limit (LOD) of Zn-MOF towards Cr2O72− is as low as 1.21 and 5.46 μM with large quenching constant (Ksv), respectively. The LOD in H2O solution is lower than the benchmark of drinking water recommended by United States Environmental Protection Agency (USEPA, 1.92 μM). Moreover, a possible weak interaction mechanism induced by competitive energy absorption is suggested by multiple experiments.
Endoscopic Treatment of Pilonidal Sinus Disease in Paediatric Patients – A Study in Western Australia
Authors: O’Sullivan Jessica Lesley , Gera Parshotam 
Published: May 2024

Abstract

Background
Pilonidal disease is considered a spectrum of disease ranging from acute abscesses to a chronic
state most often associated with draining sinuses in the gluteal fold. An increasing prevalence is
seen in children with 3 out of every 250,000 children developing pilonidal sinus disease
(PSD). Although this is a common disease within general and paediatric surgery departments
worldwide, there is yet to be an agreement on a ‘Gold Standard ‘of treatment. Minimally invasive treatment techniques such as EPSiT are a more recent development for pilonidal disease that are showing promising results.
Method
This study is a retrospective study of children and adolescents who underwent excision of pilonidal disease using EPSiT by a single paediatric surgeon in Western Australia. The primary outcome measure is recurrence, secondary outcomes include complications, length of hospital stay, time to return to school/work, post-operative pain, and time to complete wound healing.
Results
No patients suffered recurrence or wound complications at mean follow up of thirteen months. No patients were readmitted to hospital for procedure related complications. All patients reported complete wound healing at an average of twenty-eight days and definitive total wound closure at six weeks post operatively. All patients reported the ability to resume daily activities at 2-4 days post operatively.
Conclusion
PEPSiT is a promising method of treating paediatric PSD and may represent a
new 'Gold Standard’ of treatment in these patients. Our results were comparable to
other studies in the literature. However, more studies and large-scale randomized control trials
are necessary in the paediatric patient cohort.
Level of Evidence: IV
Supportive local treatment of diseases of the distal colon of various inflammatory genesis in the outpatient department
Authors: Belik B. M. , Kovalev A. N. , Mirkin Ya. B. , Ponomarenko M. E. , Kryachko A. A. , Skorlyakov V. V. , Babiev V. F. , Kivva A. N. 
Published: May 2024

Introduction. Currently, along with the improvement of the scheme of combined drug therapy with first-line anti-inflammatory drugs, important importance is attached to adjuvant topical methods of treating diseases of the distal colon of various inflammatory genesis.Aim. Evaluate the clinical efficacy of the drug on sodium hyaluronate as an adjuvant topical agent in the complex treatment of patients with diseases of the distal colon.Materials and methods. A comparative analysis of the results of drug treatment of 97 patients with diseases of the distal colon of various inflammatory genesis, which were divided into two groups, was carried out. In 46 (47.4%) patients of the I (control) group, standard drug therapy with basic anti-inflammatory drugs was performed; 51 (52.6%) patients – II (main) group, the standard program of drug treatment was supplemented with instillations into the rectum of the drug on sodium hyaluronate (0.8 mg of hyaluronic acid in 1 ml). The comparative assessment of the results of treatment took into account the severity of clinical, laboratory and endoscopic manifestations of the disease.Results. In patients of the main group, there was a significant reduction in the healing time of erosions and ulceration of the mucous membrane of the distal colon compared with patients in the control group (29.4 ± 5.7 days, respectively, versus 52.8 ± 6.2 days). Also, in patients of the main group, it was possible to achieve stable clinical and laboratory remission of the disease at an earlier time, restoration of patients’ ability to work, and improvement of their quality of life.Conclusion. The results obtained by us allow us to recommend the drug on sodium hyaluronate as an additional topical drug for the medical treatment of chronic diseases of the distal colon of various inflammatory genesis in outpatient settings.
Comparative morphological and morphometric analysis of the structure of the wall of the calf venous collectors
Authors: Sannikov A. B. , Morozova O. N. , Shaydakov E. V. 
Published: May 2024

Introduction. Development of venous pathology of the lower extremities is based on morphological changes in the vascular wall. Further structural restructuring of the vein wall in chronic venous insufficiency will depend on the initially present differences in the structure of their walls.Aim. To conduct a comparative analysis of morphological and morphometric features of the structure of the walls of the main venous collectors of the lower leg: the great saphenous vein, intramuscular veins, posterior tibia veins and poplitea vein.Materials and methods. Histological studies were carried out on autopsy material of the veins of 32 people who died from various causes aged 35 to 50 years and 10 amputated limbs. Morphological studies of the venous wall were carried out by light microscopy with digital photo processing.Results. A quantitative comparative analysis of morphological changes with the determination of the volume fraction of smooth muscle and connective tissue elements of various membranes of the venous wall, as well as measurement of the total thickness of the vascular wall and its ratio to the lumen of the veins showed statistically significant differences at a significance level of p < 0.05.Discussion. Despite the similarity of the general morphological picture of the structure of various venous collectors of the lower leg, structural differences were established, which concerned the volume fraction of the presence of both smooth muscle and connective tissue elements.Conclusion. The comparative qualitative and quantitative statistical analysis of morphological and morphometric features of the structure of the walls of the main venous collectors of the lower leg allows us to make an assumption about the unequal role of individual main venous collectors in the work of the muscular-venous pump of the lower leg as a whole.
Assessing the effects of dam regulation on multiscale variations in river hydrological regime and ecological responses
Authors: Wang Hongxiang , Bai Xiangyu , Yang Huan , Jiao Xuyang , Huang Lintong , Guo Wenxian 
Published: May 2024

ABSTRACT

Using a combination of the long short-term memory model and hydrological change indicators, this study proposes an assessment framework at inter-annual and intra-annual scales to quantify the hydrological regime changes and ecological event responses caused by the regulation of the Three Gorges Dam (TGD) in the upper reaches of the Yangtze River. The results indicate that during the post-TGD period (2004–2019), 2 indicators of the natural flow regime undergo a high degree of alteration at the inter-annual scale, which increase to 12 when regulated flows are considered. Furthermore, we find that while climate and incoming water change significantly reduces the annual flow and monthly flow during the flood season, it increases the complexity (79%) and ecodeficit at the seasonal scale (94%). Among the 32 indicators of hydrologic alteration, TGD is the dominant factor influencing changes in 20 indicators, increasing the magnitude of low-flow events, decreasing the frequency of high-flow pulses, and advancing the timing of 1-day minimum flow (43 Julian date). From the hydrological perspective, the altered rising water conditions due to TGD regulation may cause an average decrease of 19.5% in the fry abundance for the Four Famous Major Carps.
Development of an electrocoagulation method using alternating pulse current to treat wastewater generated by tanneries
Authors: Al Hariri Hassoun , Atallah Fouad , Hathal Mustafa M. 
Published: May 2024

ABSTRACT

Electrocoagulation has several disadvantages, such as electrode passivation, generation of heat due to energy consumption, and significant sludge formation. The constraints restrict its application in the treatment of tannery effluent. Therefore, the introduction of alternating pulse current electrocoagulation (APC-EC) aimed to resolve these concerns. We conducted an empirical examination of the research, specifically focusing on the frequency and stirring speed. This study investigated the impact of different parameters on the effectiveness of removing chemical oxygen demand (COD), the turbidity of trivalent chromium, and the energy consumption of perforated aluminium (Al) electrodes. The implementation of the central composite design (CCD) within the surface response design technique has enhanced multiple operational parameters in the APC-EC process for the treatment of tannery effluent. By employing our advanced mathematical and statistical techniques, we successfully eliminated the highest levels of COD, chromium (III) ion, and turbidity, all while significantly reducing energy usage. As a result, we achieved the optimal conditions for our process. The components that were eliminated most rapidly at 11000 Hz, 576 rpm, and 30 minutes were COD (70.3%), turbidity (96%), and 89.56%. The surface response results provide a description of the frequency dynamics of APC-EC.
CARACTERIZAÇÃO DA PRODUÇÃO PATENTÁRIA DE UM INSTITUTO FEDERAL DE EDUCAÇÃO DO NORDESTE
Authors: Leal Raimundo Nonato , Oliveira Francisca Mesquita de , Rocha Lízia Barbosa , Feitosa Samylla de Moura 
Published: May 2024

A criação de algo novo, que vá facilitar e melhorar em algum aspecto a vida humana, é sempre um desafio ante a quantidade de variantes implicadas. Diante disso surge a necessidade de regulamentação para a segurança do invento e do inventor, sendo o registo de uma patente a forma seguro de se resguardar. Este trabalho evidencia a importância da inovação nas Instituições Federais de Ciência e Tecnologia, através da realização do mapeamento no banco de dados do INPI, referente ao depósito de patentes inscritas pelo Instituto Federal do Piauí, no período de 2014 a 2021. Realizou-se um comparativo quantitativo no depósito de patentes a nível de Instituto Federais da região Nordeste a fim de nortear o IFPI perante os demais IFs da região. O artigo demostra a importância das instituições como impulsionadores locais de inovações e foi identificado o quantitativo e as características de alguns aspectos importantes quanto ao mapeamento da quantidade de depósito de patentes, suas fases, a quantidade de depósitos publicados, suas parcerias, e suas áreas de conhecimento. A pesquisa demostra que o IFPI se tornou um promotor de inovação e um depositário de patentes, seus registros permitiram mapear a caracterização dos depósitos patentários em vários aspectos e não há ainda a concessão de nenhuma patente depositada, visto que é um processo lento. Feita a análise, indica-se que o registro de patentes no IFPI é um campo relativamente "novo" e passível de exploração pela pesquisa e tecnologia e com algumas melhorias pode se destacar para a região.
Correlation between Metabolic Syndrome and Gastric Cancer: Results of an Evidence-Based Strategy in Oriental Populations
Authors: Liang Tong , Wang Junhong , Gao Zhenhua , Da Mingxu 
Published: May 2024

Background:
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors,
including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. Gastric cancer
(GC) is a common malignancy with significant mortality rates. The relationship between MetS
and GC risk remains controversial. This systematic review and meta-analysis aimed to evaluate
the correlation between MetS and GC.

Methods:
Case-control studies investigating the association between MetS and GC were obtained
from various databases, including China National Knowledge Infrastructure (CNKI), SinoMed,
Embase, Web of Science, The Cochrane Library, and PubMed. The search was performed
from the inception of each database up until September, 2023. Two researchers independently
screened the literature, extracted data, and assessed the quality of the included studies.
A meta-analysis of the included literature was conducted using Stata 12.0 software. The study
protocol is registered in PROSPERO (CRD42023490410).

Results:
A total of eight studies involving a combined sample size of forty-four thousand eight
hundred and seventy participants were included in the meta-analysis. The findings revealed that
the risk of developing GC was not significantly associated with body mass index, triglycerides,
hypertension, high fasting glucose, or MetS. However, it was found to be positively correlated
with high-density lipoprotein cholesterol (OR = 1.69, 95%CI: 1.35-2.12).

Conclusion:
This meta-analysis suggests that MetS is not significantly associated with an increased
risk of GC. The risk of GC increases with the presence of individual MetS components,
such as high-density lipoprotein cholesterol. Therefore, GC prevention strategies should include
lifestyle modifications and targeted interventions to manage MetS and its components.

Trial Registration:
CRD42023490410 (PROSPERO).
Suicidal Thoughts and Self-injurious Behavior Associated With Glucagon-Like Peptide-1 Receptor Agonists - A Review
Authors: Maideen Naina Mohamed Pakkir , Al Rashid Sultan 
Published: May 2024

Abstract:
GLP-1 receptor agonists mimic the actions of GLP-1 and are used to manage type 2
diabetes and help with weight loss. In recent times, antidiabetic GLP-1 receptor agonists have
been misused widely for weight loss. This review article focuses on some serious side effects
of GLP-1 receptor agonists, notified by different regulatory agencies. We searched the literature
in online databases such as Medline/Pubmed/PMC, Google Scholar, Science Direct, Ebsco,
Scopus, Web of Science, Embase, and reference lists to identify publications relevant to
the serious side effects associated with the use of GLP-1 receptor agonists. Various pharmacovigilance
analyses and notifications from different regulatory agencies have documented the
occurrence of suicidal thoughts and self-injurious behavior associated with the use of GLP-1
receptor agonists. Healthcare professionals should be aware of GLP-1 receptor agonistsassociated
suicidal thoughts and self-injurious behavior. Patients should not misuse/abuse antidiabetic
GLP-1 receptor agonists and should consult their physician before using any GLP-1
receptor agonists for weight loss.
Problemas de las autonomías en el ordenamiento jurídico de Bolivia
Authors: Cruz Aduviri Fidel 
Published: May 2024

Bolivia como Estado unitario, mediante la Constitución Política de 2009 se constituye en un Estado con autonomías, emergente de la pretensión legítima de algunas regiones para la conformación de un Estado federal; el objetivo consiste en establecer los principales problemas para la consolidación de un Estado autonómico; a través del análisis del ordenamiento jurídico, la situación sociopolítica y económica; concluyendo que no existe voluntad política del gobierno para su desarrollo, la cual se verifica en la falta: de determinación de competencias para una mayor autonomía; de concertación para un pacto fiscal, redistribución de recursos económicos y resolución de asimetrías, e inexistente desarrollo de leyes en materia indígena y medio ambiente, así como de mecanismos de judicialización para su afianzamiento.
Analisis Pengaruh Teknologi Digital Terhadap Pertumbuhan Ekonomi di Pulau Jawa
Authors: Rochmahwati Milda Rizki 
Published: May 2024

The purpose of this study is to find out how much influence digital technology has on economic growth in Java. The method used in this research is using panel data regression. The results of this study indicate that smartphone users, the value of labor e-commerce transactions and the Human Development Index (IPM) have a positive and significant effect on economic growth. The results of the study show that the number of internet users has a negative and significant effect on economic growth.

Tujuan penelitian ini adalah untuk mengetahui seberapa besar pengaruh teknologi digital terhadap pertumbuhan ekonomi di Pulau Jawa. Metode yang digunakan dalam penelitian ini yaitu menggunakan regresi data panel. Dari hasil penelitian ini menunjukkan bahwa variabel pengguna smartphone, nilai transaksi e-commerce tenaga kerja dan Indeks Pembangunan Manusia (IPM) berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi. Hasil penelitian menunjukkan bahwa jumlah pengguna internet negatif dan signifikan berpengaruh terhadap pertumbuhan ekonomi.
Analisis Pengaruh Tingkat Pendidikan, Pendapatan Perkapita, Belanja Daerah di Bidang Pendidikan dan Kesehatan Terhadap Kemiskinan di Provinsi Jawa Timur
Authors: Mantika Ade Ana , Kusuma Hendra 
Published: May 2024

This study aims to analyze the effect of education level, income per capita, regional spending on education and health on poverty in the districts/cities of East Java Province. The data used in this research is secondary data. The data analysis method used is panel data regression analysis in 9 cities and 29 regencies of East Java Province from 2019 – 2021. The results show that the education level variable in Elementary School has a negative and insignificant effect, the education level variable in Senior High School is positive does not mean to give a significant effect. Meanwhile, the variable level of education in junior high school, income per capita and local spending on education has a negative and significant effect. Meanwhile, regional expenditure variables in the health sector have a positive and significant influence.

Penelitian ini tujuannya untuk menganalisa pengaruh tingkat pendidikan, pendapatan per kapita, belanja daerah di bidang pendidikan dan kesehatan terhadap kemiskinan di Kabupaten/Kota Provinsi Jawa Timur. Data yang dipergunakan pada penelitian ini yaitu data sekunder. Metode analisa data yang dipakai ialah analisis regresi data panel di 9 kota dan 29 kabupaten Provinsi Jawa Timur dari tahun 2019 – 2021. Hasilnya memperlihatkan bahwa variabel tingkat pendidikan pada Sekolah Dasar memberi pengaruh negatif dan tidak signifikan, variabel tingkat pendidikan pada Sekolah Menengah Atas secara positif tidak bermakna memberi pengaruh signifikan. Sedangkan variabel tingkat pendidikan pada Sekolah Menengah Pertama, pendapatan per kapita dan belanja daerah di bidang pendidikan memberi pengaruh negatif dan signifikan. Sementara variabel belanja daerah di bidang kesehatan memberi pengaruh positif dan signifikan.
A Review: Novel Granulation Technology
Authors: S Saravanan , Bisht Meena 
Published: May 2024

All the pharmaceutical Active pharmaceutical Ingredients (API) and Pharmaceutical excipients will have different particle size. While formulating a dosage form, particles from raw materials will tend to separate from other due to their rheological properties. There could be a condition where fine particles separate from the larger particles causing demixing or uneven distribution of active with its excipients leading to tablet content uniformity issue. To overcome this problem, particle enlargement or particle cohesiveness with or without additional aid is necessary, which could be achieved by granulation. Hence granulation technology is important in the formulation of pharmaceutical oral solid dosage form. Granulation is the process of adhering fine particles agglomerate into a large particle using two most common methods i.e. wet granulation and dry granulation/compaction. Day by day technological innovation is happening in all fields and pharmaceutical granulation process is also not an exemption. The objective of present review is to focus the novel granulation technology and how it is differing from the conventional granulation technology.