bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquisition of green algal photobionts enables both chlorolichens and chloro-cyanolichens to activate photosynthesis at low humidity without liquid water
Authors: Worthy Fiona Ruth , Schaefer Douglas Allen , Wanasinghe Dhanushka , Xu Jian Chu , Wang Li Song , Wang Xin Yu 
Published: April 2024

Abstract
Cyanobacteria require liquid water for photosynthesis, whereas green algae can photosynthesise with water vapour alone. We discovered that several Lobaria spp. which normally have cyanobacteria as the sole photobiont, in some regions of the trans-Himalayas also harboured green algae. We tested whether green algal acquisition was: limited to high elevations; obtained from neighbouring chloro-Lobaria species; enabled photosynthesis at low humidity. Lobaria spp. were collected from 2000 to 4000 m elevation. Spectrophotometry quantified green algal abundance by measuring chlorophyll b (absent in cyanobacteria). Thalli cross-sections visually confirmed green algal presence. We sequenced gene regions: Lobaria (ITS-EF-1α-RPB2), green algae (18S-RBC-L) and Nostoc (16S). Phylogenetic analysis determined myco-photobiont associations. We used a custom closed-circuit gas exchange system with an infrared gas analyser to measure CO2 exchange rates for desiccated specimens at 33%, 76%, 86% and 98% humidity. Cross-sections revealed that the photobiont layers in putative cyano-Lobaria contained both cyanobacteria and green algae, indicating that they should be considered chloro-cyanolichens. Chloro-Lobaria had no visible cephalodia nor cyanobacteria in the photobiont layer. Chloro-Lobaria and chloro-cyano-Lobaria had comparable levels of chlorophyll b. Chloro-Lobaria usually contained Symbiochloris. Chloro-cyano-Lobaria mainly associated with Parachloroidium and Nostoc; infrequently with Symbiochloris, Apatococcus, Chloroidium, Pseudochlorella, Trebouxia. Sequences from two green algal genera were obtained from within some thalli. Desiccated specimens of every Lobaria species could attain net photosynthesis with light exposure and 33% humidity. CO2 exchange dynamics over a five-day period differed between species. At all elevations, chloro-cyano-Lobaria spp. had abundant green algae in the photobiont layer, but green algal strains mostly differed to those of chloro-Lobaria spp. Both chloro-Lobaria and chloro-cyano-Lobaria were capable of conducting photosynthesis without liquid water. The data strongly suggest that they attained positive net photosynthesis.
Plastic Surgeons’ Perspective on the FDA Breast Implant Regulatory Mandates
Authors: Villanueva Karie , Gupta Nisha , Alnaseri Tahera , Da Lio Andrew L , Roostaeian Jason , DeLong Michael 
Published: April 2024

Abstract

Background
In 2021, the US FDA issued a new checklist, labeling, and rupture-screening recommendations for breast implants to improve the decision-making process.

Objectives
The aim of this study was to understand plastic surgeons' perspective on these changes and their perceived impact on clinical practice.

Methods
In September 2023, a 27-question multiple-choice cross-sectional survey was distributed to 4352 active members of the American Society of Plastic Surgeons to evaluate attitudes on the FDA's black-box warning, informed decision checklist, and updated rupture-screening recommendations.

Results
A total of 591 responses were collected (13.6%). The majority of respondents were between the ages of 45 and 64 years (58%) and had been in practice for more than 20 years (52%). Surgeons felt that some additions were appropriate; however, the majority (57%) stated that the informed decision checklist did not have a positive impact on workflow; 66% were also neutral or disagreed with the reported incidence rates related to complications and cancer. Nearly half of respondents (47%) did not feel the black-box warning improved their patients’ understanding of the risks and benefits. Additionally, 47% of respondents also believed these requirements, in combination, did not improve the overall patient experience with implants.

Conclusions
Respondents had an overall positive response towards the addition of risk information provided by the FDA-issued guidance and updates to rupture-screening recommendations. However, they remained divided as to whether the black-box warning and patient decision checklist had an overall positive impact on clinical practice patterns.

Level of Evidence: 4
AI and machine learning in medical imaging: key points from development to translation
Authors: Samala Ravi K , Drukker Karen , Shukla-Dave Amita , Chan Heang-Ping , Sahiner Berkman , Petrick Nicholas , Greenspan Hayit , Mahmood Usman , Summers Ronald M , Tourassi Georgia , Deserno Thomas M , Regge Daniele , Näppi Janne J , Yoshida Hiroyuki , Huo Zhimin , Chen Quan , Vergara Daniel , Cha Kenny H , Mazurchuk Richard , Grizzard Kevin T , Huisman Henkjan , Morra Lia , Suzuki Kenji , Armato Samuel G , Hadjiiski Lubomir 
Published: April 2024

Abstract
Innovation in medical imaging artificial intelligence (AI)/machine learning (ML) demands extensive data collection, algorithmic advancements, and rigorous performance assessments encompassing aspects such as generalizability, uncertainty, bias, fairness, trustworthiness, and interpretability. Achieving widespread integration of AI/ML algorithms into diverse clinical tasks will demand a steadfast commitment to overcoming issues in model design, development, and performance assessment. The complexities of AI/ML clinical translation present substantial challenges, requiring engagement with relevant stakeholders, assessment of cost-effectiveness for user and patient benefit, timely dissemination of information relevant to robust functioning throughout the AI/ML lifecycle, consideration of regulatory compliance, and feedback loops for real-world performance evidence. This commentary addresses several hurdles for the development and adoption of AI/ML technologies in medical imaging. Comprehensive attention to these underlying and often subtle factors is critical not only for tackling the challenges but also for exploring novel opportunities for the advancement of AI in radiology.
Right heart strain in arrhythmogenic right ventricular cardiomyopathy: implications for cardiovascular outcome
Authors: Anwer Shehab , Stollenwerk Lauren , Winkler Neria E , Guastafierro Francesca , Hebeisen Monika , Akdis Deniz , Saguner Ardan M , Brunckhorst Corinna , Duru Firat , Tanner Felix C 
Published: April 2024

Abstract

Aims
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by progressive myocardial dysfunction and associated with an increased risk of major cardiovascular (CV) events. To determine right heart strain (ventricular and atrial global longitudinal strain (RVGLS and RAGLS) in patients with definite ARVC and its association with adverse events during follow-up.

Methods and results
RVGLS and RAGLS were analysed in focused right heart apical views from 70 patients using TomTec ImageArena and association with a composite endpoint was determined (sustained ventricular arrhythmia and cardiovascular death). Over a median follow-up duration of 4.9 years, 26 (37%) patients met the endpoint. RVGLS was significantly impaired in the event group (−11.5 [−13.3 to −10.2] %) vs. the no-event group (−15.8 [−17.1 to −14.5] %, P &lt; 0.001), and so was RAGLS (22.8 [21.4–27.4] % vs. 31.5 [25.1–39.6] %, respectively, P &lt; 0.001). In Cox regression, RVGLS (HR 1.36, P &lt; 0.001) and RAGLS (HR 0.92, P = 0.002) were associated with a higher risk of adverse events. In multivariable Cox regression models, RVGLS and RAGLS remained independent of and were incremental to age, gender, and conventional RV parameters, and model fitness was improved when RVGLS and RAGLS were applied together rather than alone.

Conclusion
RVGLS and RAGLS are more impaired in patients with adverse events and associated with adverse events independent of age, gender, and conventional RV parameters. When RVGLS and RAGLS are applied together, prediction models are improved suggesting that right heart strain may form part of the echocardiographic routine protocol in patients with ARVC.
Stiff right atrial syndrome? A complex clinical case report utilizing multimodality imaging and invasive hemodynamics
Authors: Krishnarao Krithika , Yip Daniel S , Goswami Rohan M , Leoni Juan C , Patel Parag C 
Published: April 2024

Abstract

Background
Stiff left atrial syndrome is a well-established cause of heart failure symptoms. A parallel entity involving the right atrium (RA) has not previously been described. We present a case of refractory right heart failure (RHF) 12 years following orthotopic heart transplantation.

Case summary
Patient underwent annuloplasty ring placement for severe tricuspid regurgitation in 2018 and kidney transplantation in 2020. The use of multimodality imaging and a multidisciplinary approach suggested a stiff RA as a potential etiology to refractory symptoms. Redo-heart and kidney transplantation in March 2021 led to the resolution of symptoms without recurrence.

Discussion
We propose stiff right atrial syndrome that may need to be considered in the setting of refractory RHF primarily suggested by significant right atrial enlargement and restrictive physiology.
Subjective–Objective Sleep Discrepancy in a Predominately White and Educated Older Adult Population: Examining the Associations With Cognition and Insomnia
Authors: Musich Madison , Beversdorf David Q , McCrae Christina S , Curtis Ashley F 
Published: April 2024

Abstract

Objectives
This study examined associations between various cognitive domains and sleep discrepancy (self-reported vs objectively measured sleep), and evaluated interactive associations with insomnia status (non-insomnia vs insomnia).

Methods
Older adults (N = 65, Mage = 68.72, SD = 5.06, 43 insomnia/22 non-insomnia) aged 60+ reported subjective sleep (7 days of sleep diaries), objective sleep assessment (one-night polysomnography, PSG, via Sleep Profiler during the 7-day period), and completed cognitive tasks (National Institutes of Health Toolbox-Cognition Battery) measuring attention and processing speed, working memory, inhibitory control, cognitive flexibility, and episodic memory. The sleep diary variable corresponding to the same one night of PSG was used to calculate the sleep discrepancy (diary minus PSG parameter) variables for total sleep time (TST), sleep onset latency, wake after sleep onset, and sleep efficiency. Regression analyses determined independent and interactive (with insomnia status) associations between cognition and sleep discrepancy, controlling for age, sex, apnea–hypopnea index, and sleep medication usage.

Results
Working memory interacted with insomnia status in associations with sleep discrepancy related to TST and sleep efficiency. In those with insomnia, worse working memory was associated with shorter self-reported TST (p = .008) and lower sleep efficiency (p = .04) than PSG measured.

Discussion
In older adults with insomnia, worse working memory may be a contributing factor to sleep discrepancy. Future investigations of underlying neurophysiological factors and consideration of other objective sleep measures (actigraphy) are warranted. Prospective findings may help determine whether sleep discrepancy is a potential marker of future cognitive decline.
Temporal evolution of shear-induced dilatancy of rock fractures: controls from surface roughness and normal stress
Authors: Zhang Supeng , Ji Yinlin , Hofmann Hannes , Yin Qian , Li Shouding , Zhang Yuanchao 
Published: April 2024

SUMMARY
Understanding the shear-induced dilatancy of rock fractures is important for assessing the permeability evolution and seismic hazard in shale and geothermal reservoirs. The displacement dependence of fracture dilation has been well studied, while the influence of slip velocity is poorly constrained. In this study, we combined displacement- and velocity-dependent aperture models to reproduce the transient shear-induced dilatancy of fractures in sandstone in 16 normal stress unloading tests. Our results show that the combined aperture model can describe the transient fracture aperture evolution during accelerating slip induced by normal stress unloading better than the model dependent only on slip displacement. Slip velocity could enhance the aperture increase on smoother fractures at lower normal stresses and higher slip velocities. Both the dilation factor and characteristic slip distance decrease with increasing normal stress and surface roughness, signifying reduced contribution of slip velocity to transient shear-induced dilatancy at higher normal stresses and surface roughness. The dilation angle increases with the increase of surface roughness, and this increase diminishes at higher normal stresses primarily attributable to more severe asperity wear. These findings highlight the importance of slip velocity in controlling the transient evolution of aperture and permeability of a rock fracture. Our study also provides constraints on the constitutive parameters in the combined aperture model for describing transient shear-induced fracture dilatancy. We suggest that it is crucial to incorporate the velocity-dependent aperture model to simulate the nonlinear evolution of fracture aperture in future analytical and numerical models involving coupled hydromechanical processes in geoenergy systems.
The statistical significance revolution
Authors: Neugut Alfred I , Fojo Tito 
Published: April 2024

Abstract
Statistical significance has long relied on the criterion of P less than or equal to .05. Although this threshold has generally functioned well, it has engendered some negative practices to circumvent it and been criticized as too inflexible. We concur with the statisticians and methodologists who are currently arguing for more flexibility to the P value and more reliance on the 95% confidence interval, a shift that is likely to change future practice in data analysis and interpretation for oncology.
Segmentation of the general public according to differences in knowledge and beliefs about radiation-cluster analysis by attitude, knowledge, belief and anxiety
Authors: Hirai Kei , Yamamura Asayo , Matsumura Yuko , Miura Asako , Yagi Ekou , Fujino Ryohei , Tsubokura Masaharu , Ohtaka Fumio 
Published: April 2024

Abstract
Following the 2011 Fukushima Daiichi Nuclear Power Plant accident, public behaviors have been marked by excessive avoidance and stigma, driven by fear and uncertainty regarding radiation exposure and its health implications. Despite extensive media dissemination of information on radiation, the precise nature of the public’s knowledge, beliefs and the resultant behavioral responses remain unclear. This study aimed to segment the population based on their attitudes, knowledge, beliefs and anxiety levels about radiation, correlating these factors with their cognitive and behavioral responses to radiation exposure. Surveying 2400 individuals, we identified seven distinct segments that illustrated a spectrum of health concerns, even among those well-informed about radiation. Notably, individuals with higher health anxiety were found to reject discriminatory prejudices linked to radiation, yet they tended to distrust official information, potentially as a psychological mechanism to justify their avoidance behaviors. These findings underscore the need for tailored communication strategies that address the complex landscape of radiation-related perceptions and misinformation.
Regulatory cellular and molecular networks in the bone microenvironment during aging
Authors: Zhang Lingli , Wang Zhikun , Zhang Yuan , Ji Rui , Li Zhiben , Zou Jun , Gao Bo 
Published: April 2024

Abstract
Age-induced abnormalities in bone metabolism disrupt the equilibrium between bone resorption and formation. This largely stems from disturbances in bone homeostasis, in which signaling pathways exert a significant regulatory influence. Aging compromises the functionality of the bone marrow mesenchymal stem cells (BMSCs), ultimately resulting in tissue dysfunction and pathological aging. Age-related bone degradation primarily manifests as reduced bone formation and the increased accumulation of bone marrow fat. Cellular senescence diminishes bone cell vitality, thereby disrupting the balance of bone remodeling. Intensive osteoclast differentiation leads to the generation of more osteoclasts and increased bone resorption. This review provides insight into the impact of aging on bone, encompassing bone cell states during the aging process and bone signaling pathway transformations. It primarily delves into aging-related signaling pathways, such as the bone morphogenetic protein/Smad, Wnt/β-catenin, osteoprotegerin/receptor activator of NF-κB ligand/receptor activator of NF-κB, connexin43/miR21, and nuclear factor erythroid 2-related factor 2/antioxidant response element pathways, seeking to enhance our comprehension of crucial bone cells and their secretory phenotypes during aging. Furthermore, the precise molecular regulatory mechanisms underlying the interactions between bone signaling pathways and aging are investigated.
Time-domain analysis of multiwaveband flares from AD Leonis
Authors: Zhang Xuying , Li Jixuan , Gao Yang , Qian Lei 
Published: April 2024

ABSTRACT
Radio bursts of magnetically active stars reveal the intensity and activity of the stellar magnetic field. They may also be related to the planets around the stars. We monitored a radio-active star, AD Leonis, 3000 s d−1 for 17 d in 2020 November, and 5000 s d−1 for 5 d in 2023 July with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). Based on the simultaneous flux increases in Stokes I and Stokes V, one left-hand circular polarized radio burst is identified. The $\sim 50~{{\ \rm per\ cent}}$ degree of circular polarization indicates the burst being originated from non-thermal radiation related to the stellar magnetic field. Combining the newly discovered burst with previous observations of radio and X-ray bursts from AD Leonis, we did a periodicity analysis for the 49 bursts in total. No periodicity with confidence level &gt;3σ is found, while a candidate period of 3.04 d at ≈2σ confidence level is presented and discussed. Results of recent FAST observations and the periodicity analysis suggest a more compact campaign of observation towards this source, from which a more optimistic result of period search could be achieved.
The M33 synoptic stellar survey. III. Miras and LPVs in griJHKS
Authors: Konchady Tarini , Macri Lucas M , Yan Xiaomeng , Huang Jianhua Z 
Published: April 2024

ABSTRACT
We present the results of a search for Miras and long-period variables (LPVs) in M33 using griJHKS archival observations from the Canada–France–Hawaii Telescope. We use multiband information and machine learning techniques to identify and characterize these variables. We recover ∼1300 previously discovered Mira candidates and identify ∼13 000 new Miras and LPVs. We detect for the first time a clear first-overtone pulsation sequence among Mira candidates in this galaxy. We use O-rich, fundamental-mode Miras in the LMC and M33 to derive a distance modulus for the latter of μ = 24.629 ± 0.046 mag.
VIRA: an exoplanet atmospheric retrieval framework for JWST transmission spectroscopy
Authors: Constantinou Savvas , Madhusudhan Nikku 
Published: April 2024

ABSTRACT
JWST observations are leading to important new insights into exoplanetary atmospheres through transmission spectroscopy. In order to harness the full potential of the broad spectral range and high sensitivity of JWST, atmospheric retrievals of exoplanets require a high level of robustness and accuracy in the underlying models. We present the VIRA retrieval framework which implements a range of modelling and inference capabilities motivated by early JWST observations of exoplanet transmission spectra. This includes three complementary approaches to modelling atmospheric composition, three atmospheric aerosol models, including a physically motivated Mie scattering approach, and consideration of correlated noise. VIRA enables a cascading retrieval architecture involving a sequence of retrievals with increasing sophistication. We demonstrate VIRA using a JWST transmission spectrum of the hot Saturn WASP-39b in the ∼1–5 $\mu$m range. In addition to confirming prior chemical inferences, we retrieve molecular abundances for H2O, CO, CO2, SO2, and H2S, resulting in supersolar elemental abundances of log(O/H) = −2.0 ± 0.2, log(C/H) = −2.1 ± 0.2, and log(S/H) = −3.6 ± 0.2, along with C/O and S/O ratios of $0.83^{+0.05}_{-0.07}$ and $0.029^{+0.012}_{-0.009}$, respectively, in the free chemistry case. The abundances correspond to $20.1^{+10.5}_{-8.1}\times$, $28.2^{+16.3}_{-12.1}\times$, and $20.8^{+10.3}_{-7.5}\times$ solar values for O/H, C/H, and S/H, respectively, compared to C/H = 8.67 ± 0.35 × solar for Saturn. Our results demonstrate how JWST transmission spectroscopy combined with retrieval frameworks like VIRA can measure multi-elemental abundances for giant exoplanets and enable comparative characterization with solar system planets.
Metabolism-dependent secondary effect of anti-MAPK cancer therapy on DNA repair
Authors: Aubé Fabien , Fontrodona Nicolas , Guiguettaz Laura , Vallin Elodie , Fabbri Lucilla , Lapendry Audrey , Vagner Stephan , Ricci Emiliano P , Auboeuf Didier 
Published: April 2024

Abstract
Amino acid bioavailability impacts mRNA translation in a codon-dependent manner. Here, we report that the anti-cancer MAPK inhibitors (MAPKi) decrease the intracellular concentration of aspartate and glutamate in melanoma cells. This coincides with the accumulation of ribosomes on codons corresponding to these amino acids and triggers the translation-dependent degradation of mRNAs encoding aspartate- and glutamate-rich proteins, involved in DNA metabolism such as DNA replication and repair. Consequently, cells that survive MAPKi degrade aspartate and glutamate likely to generate energy, which simultaneously decreases their requirement for amino acids due to the downregulation of aspartate- and glutamate-rich proteins involved in cell proliferation. Concomitantly, the downregulation of aspartate- and glutamate-rich proteins involved in DNA repair increases DNA damage loads. Thus, DNA repair defects, and therefore mutations, are at least in part a secondary effect of the metabolic adaptation of cells exposed to MAPKi.
Controversies in neuro-oncology: Focal proton versus photon radiation therapy for adult brain tumors
Authors: Eekers Danielle B P , Zegers Catharina M L , Ahmed Kamran A , Amelio Dante , Gupta Tejpal , Harrabi Semi Ben , Kazda Tomas , Scartoni Daniele , Seidel Clemens , Shih Helen A , Minniti Giuseppe 
Published: April 2024

Abstract
Radiation therapy (RT) plays a fundamental role in the treatment of malignant and benign brain tumors. Current state-of-the-art photon- and proton-based RT combines more conformal dose distribution of target volumes and accurate dose delivery while limiting the adverse radiation effects. PubMed was systematically searched from from 2000 to October 2023 to identify studies reporting outcomes related to treatment of central nervous system (CNS)/skull base tumors with PT in adults. Several studies have demonstrated that proton therapy (PT) provides a reduced dose to healthy brain parenchyma compared with photon-based (xRT) radiation techniques. However, whether dosimetric advantages translate into superior clinical outcomes for different adult brain tumors remains an open question. This review aims at critically reviewing the recent studies on PT in adult patients with brain tumors, including glioma, meningiomas, and chordomas, to explore its potential benefits compared with xRT.