bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic analysis of intracranial aneurysms with moving parent arteries: Basilar tip aneurysms
Authors: Sforza Daniel M. , Löhner Rainald , Putman Christopher , Cebral Juan Raul 
Published: March 2010

AbstractThe effects of parent artery motion on the hemodynamics of basilar tip saccular aneurysms and its potential effect on aneurysm rupture were studied.The aneurysm and parent artery motions in two patients were determined from cine loops of dynamic angiographies. The oscillatory motion amplitude was quantified by registering the frames. Patient‐specific computational fluid dynamics (CFD) models of both aneurysms were constructed from 3D rotational angiography images. Two CFD calculations were performed for each patient, corresponding to static and moving models. The motion estimated from the dynamic images was used to move the surface grid points in the moving model. Visualizations from the simulations were compared for wall shear stress (WSS), velocity profiles, and streamlines.In both patients, a rigid oscillation of the aneurysm and basilar artery in the anterio‐posterior direction was observed and measured. The distribution of WSS was nearly identical between the models of each patient, as well as major intra‐aneurysmal flow structures, inflow jets, and regions of impingement.The motion observed in pulsating intracranial vasculature does not have a major impact on intra‐aneurysmal hemodynamic variables. Parent artery motion is unlikely to be a risk factor for increased risk of aneurysmal rupture. Copyright © 2010 John Wiley & Sons, Ltd.
Testicular leydig cell tumor diagnosed on fine needle aspiration
Authors: Handa Uma , Sood Tanvi , Punia Rajpal Singh 
Published: March 2010

AbstractWe report on the cytopathologic findings of a Leydig cell tumor of the testis in an adult male with no evidence of endocrine dysfunction. The preoperative diagnosis was based on fine needle aspiration cytology (FNAC) and was subsequently confirmed on histomorphology. The cytologic smears were cellular and showed tumor cells arranged singly, as well as in dyscohesive clusters. The tumor cells were large, round to polygonal, with indistinct cytoplasmic margins and pale, abundant, granular to vacuolated cytoplasm. A few intranuclear Reinke's crystals that are considered pathognomonic and essential for the diagnosis were seen. The present case was of interest because of the scarcity of literature on the cytodiagnosis of this tumor. The use of FNAC for diagnosis may vitiate the need for more invasive biopsy procedures in the preoperative diagnosis of this rare testicular tumor. Diagn. Cytopathol. 2010;38:682–684. © 2009 Wiley‐Liss, Inc.
Anchoring the deficit of the anchor deficit: dyslexia or attention?
Authors: Willburger Edith , Landerl Karin 
Published: March 2010

AbstractIn the anchoring deficit hypothesis of dyslexia (Trends Cogn. Sci., 2007; 11: 458–465), it is proposed that perceptual problems arise from the lack of forming a perceptual anchor for repeatedly presented stimuli. A study designed to explicitly test the specificity of the anchoring deficit for dyslexia is presented. Four groups, representing all combinations of reading skills (high or low) and attention (high or low), were given a time estimation task in which a standard tone was compared with tones of varying length. Poor readers showed problems only if they had limited attentional skills as well, while poor readers with good attention were unaffected. It is concluded that a single deficit in time estimation is not sufficient to cause reading deficits. Copyright © 2010 John Wiley & Sons, Ltd.
Oxidomolybdenum(IV), ‐(V), ‐(VI) Complexes with Relevance to Molybdenum Enzymes: Oxygen Atom Transfer, Redox Chemistry and EPR Spectroscopy
Authors: Heinze Katja , Fischer Andreas 
Published: March 2010

AbstractThe cis‐dioxidomolybdenum(VI) complex Mo(NN′)2O2 (1) [(NN′) = N‐(4‐hydroxyphenyl)‐2‐pyrrolatocarbaldimine] transfers one oxygen atom to phosphanes PMenPh3–n (n = 0–3) to give quantitatively the respective phosphane oxides OPMenPh3–n (OAT, oxygen atom transfer). The kinetics of these OAT reactions has been investigated spectrophotometrically. When offering excess PMenPh3–n (n = 1–3), oxido(phoshane)molybdenum(IV) complexes Mo(NN′)2O(PMenPh3–n) 5a–5c are isolated and characterized by multinuclear NMR spectroscopy (1H, 13C, 31P, 15N), IR spectroscopy, UV/Vis spectroscopy and mass spectrometry. The redox chemistry of the molybdenum(IV) complexes 5a–5c and of molybdenum(VI) complex 1 has been probed by preparative one‐electron oxidation and reduction, respectively, in combination with EPR spectroscopy under strictly anhydrous conditions. The reactivity of the resulting MoV species (ligand substitution, protonation, silyation) has been investigated to shed further light onto the biomimetic catalytic cycle of OAT from water to substrates in combination with two coupled electron proton transfer reactions (CEPT).
Anionic d8 Alkyl Hydrides – Selective Formation and Reactivity of Anionic cis‐PtII Methyl Hydride
Authors: Poverenov Elena , Iron Mark A. , Gandelman Mark , Ben‐David Yehoshoa , Milstein David 
Published: March 2010

AbstractThe pincer‐type complexes [(PCN)PtR] {R = H, 2; Me, 4; PCN = C6H4[CH2P(tBu)2](CH2)2N(CH3)2} react with MeLi or Et3BHNa, to give anionic cis‐Pt(Me)H complexes [(PCN*)Pt(H)(Me)]–Li+ (Me trans to P; PCN* denotes the PCN ligand in which the amine arm is not coordinated) and [(PCN*)Pt(Me)(H)]–Na+ (H trans to P). Only the isomer in which the incoming nucleophile is situated trans to the phosphane ligand is formed. These first d8 anionic alkyl hydride complexes were fully characterized spectroscopically. The hemilabile PCN ligand allows for reversible de‐coordination of the amine arm, thereby providing a desirable balance of stability vs. reactivity. Theoretical calculations on model systems indicate a concerted mechanism in which the nucleophilic attack and the amine dissociation occur concurrently. The (unobserved) methane reductive elimination from the stable anionic methyl hydride complex [(PCN*)Pt(Me)(H)]–Li+ (3) is thermodynamically and kinetically unfavorable, as indicated by DFT. This complex reacts with electrophiles, such as water and methyl iodide, to yield exclusively methane and the corresponding organometallic product (either 2 or 4). This reactivity was also further examined by DFT.
Copper‐Catalyzed Formation of Sulfur–Nitrogen Bonds by Dehydrocoupling of Thiols with Amines
Authors: Taniguchi Nobukazu 
Published: March 2010

AbstractCopper‐catalyzed formation of sulfur–nitrogen bonds can be performed by a dehydrocoupling of aryl thiols with amines. Sulfenamides or sulfonamides can be produced by the use of a copper catalyst in air or under oxygen atmosphere. Furthermore, a reaction involving the combination of a palladium catalyst and a copper catalyst selectively afforded sulfinamides.
CE‐LIF‐MSn profiling of oligosaccharides in human milk and feces of breast‐fed babies
Authors: Albrecht Simone , Schols Henk A. , van den Heuvel Ellen G. H. M. , Voragen Alphons G. J. , Gruppen Harry 
Published: March 2010

AbstractMixtures of the complex human milk oligosaccharides (HMOs) are difficult to analyze and gastrointestinal bioconversion products of HMOs may complicate analysis even more. Their analysis, therefore, requires the combination of a sensitive and high‐resolution separation technique with a mass identification tool. This study introduces for the first time the hyphenation of CE with an electrospray mass spectrometer, capable to perform multiple MS analysis (ESI‐MSn) for the separation and characterization of HMOs in breast milk and feces of breast‐fed babies. LIF was used for on‐ and off‐line detections. From the overall 47 peaks detected in off‐line CE‐LIF electropherograms, 21 peaks could be unambiguously and 11 peaks could be tentatively assigned. The detailed structural characterization of a novel lacto‐N‐neo‐tetraose isomer and a novel lacto‐N‐fucopentaose isomer was established in baby feces and pointed to gastrointestinal hydrolysis of higher‐Mw HMOs. CE‐LIF‐ESI‐MSn presents, therefore, a useful tool which contributes to an advanced understanding on the fate of individual HMOs during their gastrointestinal passage.
Determination of cinchona alkaloids by non‐aqueous CE with MS detection
Authors: Buchberger Wolfgang , Gstöttenmayr Daniel , Himmelsbach Markus 
Published: March 2010

AbstractNon‐aqueous CZE was investigated for separation of cinchona alkaloids including diastereomeric pairs of analytes such as quinine/quinidine or cinchonine/cinchonidine. BGEs prepared in mixtures of methanol/ethanol/ACN containing formic acid and ammonium formate turned out to provide satisfactory separation selectivity. Resolution was mainly affected by the EOF which could be adjusted by the ratio of the three solvents in the BGE. Contrary to the previous articles, no addition of a chiral selector was necessary. Therefore, the hyphenation with MS was easily possible by means of a sheath‐flow‐interface. The employment of a Q‐TOF MS resulted in mass accuracies typically better than 2 ppm, providing information about the elemental composition of the peaks and allowing identification. Detection limits of CZE‐MS were at a level of 0.04 mg/L. The applicability to samples of cinchona bark could be demonstrated, so that this technique can be seen as an attractive alternative to HPLC methods in pharmaceutical quality control.
Initiation of DNA interstrand cross‐link repair in mammalian cells
Authors: Hlavin Erica M. , Smeaton Michael B. , Miller Paul S. 
Published: March 2010

AbstractInterstrand cross‐links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross‐linking agents are well established in clinical use, and numerous repair proteins have been implicated in the initial events of mammalian ICL repair, the precise mechanistic details of these events remain to be elucidated. This review will summarize our current understanding of how ICL repair is initiated with an emphasis on the context (replicating, transcribed or quiescent DNA) in which the ICL is recognized, and how the chemical and physical properties of ICLs influence repair. Although most studies have focused on replication‐dependent repair because of the relation to highly replicative tumor cells, replication‐independent ICL repair is likely to be important in the circumvention of cross‐link cytotoxicity in nondividing, terminally differentiated cells that may be challenged with exogenous or endogenous sources of ICLs. Consequently, the ICL repair pathway that should be considered “dominant” appears to depend on the cell type and the DNA context in which the ICL is encountered. The ability to define and inhibit distinct pathways of ICL repair in different cell cycle phases may help in developing methods that increase cytotoxicity to cancer cells while reducing side‐effects in nondividing normal cells. This may also lead to a better understanding of pathways that protect against malignancy and aging. Environ. Mol. Mutagen., 2010. © 2010 Wiley‐Liss, Inc.
An evaluation of the ability of chemical measurements to predict polycyclic aromatic hydrocarbon-contaminated sediment toxicity toHyalella azteca
Authors: McDonough Kathleen M. , Azzolina Nicholas A. , Hawthorne Steven B. , Nakles David V. , Neuhauser Edward F. 
Published: March 2010

AbstractThe present study examined the ability of three chemical estimation methods to predict toxicity and nontoxicity of polycyclic aromatic hydrocarbon (PAH) -contaminated sediment to the freshwater benthic amphipod Hyalella azteca for 192 sediment samples from 12 field sites. The first method used bulk sediment concentrations of 34 PAH compounds (PAH34), and fraction of total organic carbon, coupled with equilibrium partitioning theory to predict pore-water concentrations (KOC method). The second method used bulk sediment PAH34 concentrations and the fraction of anthropogenic (black carbon) and natural organic carbon coupled with literature-based black carbon–water and organic carbon–water partition coefficients to estimate pore-water concentrations (KOCKBC method). The final method directly measured pore-water concentrations (pore-water method). The U.S. Environmental Protection Agency's hydrocarbon narcosis model was used to predict sediment toxicity for all three methods using the modeled or measured pore-water concentration as input. The KOC method was unable to predict nontoxicity (83% of nontoxic samples were predicted to be toxic). The KOCKBC method was not able to predict toxicity (57% of toxic samples were predicted to be nontoxic) and, therefore, was not protective of the environment. The pore-water method was able to predict toxicity (correctly predicted 100% of the toxic samples were toxic) and nontoxicity (correctly predicted 71% of the nontoxic samples were nontoxic). This analysis clearly shows that direct pore-water measurement is the most accurate chemical method currently available to estimate PAH-contaminated sediment toxicity to H. azteca. Environ. Toxicol. Chem. 2010;29:1545–1550. © 2010 SETAC
Uptake kinetics and subcellular compartmentalization of cadmium in acclimated and unacclimated earthworms (Eisenia andrei)
Authors: Yu Shuo , Lanno Roman P. 
Published: March 2010

AbstractAcclimation to cadmium (Cd) levels exceeding background concentrations may influence the ability of earthworms to accumulate Cd with minimum adverse effects. In the present study, earthworms (Eisenia andrei) were acclimated by exposure to 20 mg/kg Cd (dry wt) in Webster soil for 28 d. A 224-d bioaccumulation test was subsequently conducted with both acclimated and unacclimated worms exposed in Webster soils spiked with 20 mg/kg and 100 mg/kg Cd (dry wt). Uptake kinetics and subcellular compartmentalization of Cd were examined. Results suggest that acclimated earthworms accumulated more Cd and required a longer time to reach steady state than unacclimated worms. Most of the Cd was present in the metallothionein (MT) fraction. Cadmium in the MT fraction increased approximately linearly with time and required a relatively longer time to reach steady state than Cd in cell debris and granule fractions, which quickly reached steady state. Cadmium in the cell debris fraction is considered potentially toxic, but low steady state concentrations observed in the present study would not suggest the potential for adverse effects. Future use of earthworms in ecological risk assessment should take into consideration pre-exposure histories of the test organisms. A prolonged test period may be required for a comprehensive understanding of Cd uptake kinetics and compartmentalization. Environ. Toxicol. Chem. 2010;29:1568–1574. © 2010 SETAC
Evaluating the biotic ligand model for toxicity and the alleviation of toxicity in terms of cell membrane surface potential
Authors: Wang Peng , Zhou Dong-Mei , Li Lian-Zhen , Luo Xiao-San 
Published: March 2010

AbstractThe electrostatic nature of plant cell membrane (CM) plays significant roles in ionic interactions at the CM surface and hence in the biotic effects of metal ions. Increases in major cations (commonly Ca2+, Mg2+, H+, Na+, K+, etc.) in bulk-phase medium reduce the negativity of CM surface electrical potential (ψ0), but these slightly increase the driving force of a metal ion crossing CMs (surface-to-surface transmembrane potential difference, Em,surf). Toxicologists commonly attributes the interactions between heavy metals and common cations (e.g., H+, Ca2+, and Mg2+) to competitions for binding sites at a hypothetical CM surface ligand. The ψ0 effects are likely to be more important to metal toxicity and the alleviation of toxicity than site-specific competition. Models that do not consider ψ0, such as the biotic ligand model (BLM) and the free ion activity model (FIAM), as usually employed are likely to lead to false conclusions about competition for binding at CM surface ligands. In the present study a model incorporating ψ0 effects and site-specific competition effects was developed to evaluate metal (Cu2+, Co2+, and Ni2+) toxicities threshold (EA50, causing 50% inhibition) for higher plants. In addition, the mechanisms for the effects of common cations on toxicity of metals were also explored in terms of CM surface electrical potential. Environ. Toxicol. Chem. 2010;29:1503–1511. © 2010 SETAC
Electrocatalytic Activity of Platinum Nanoparticles Supported on Nanosilicon
Authors: Miu M. , Kleps I. , Danila M. , Ignat T. , Simion M. , Bragaru A. , Dinescu A. 
Published: March 2010

AbstractPlatinum (Pt) nanocatalysts were deposited on/inside of nanostructured silicon (nanoSi) matrix using physico‐chemical methods, i.e. E‐beam high vacuum Pt thin film and, respectively, chemically loaded Pt nanoparticles from hexachloroplatinic acid aqueous or alcoholic precursor solutions. High resolution morphological characterisations, completed by microstructural and compositional analyses have been performed to characterise the nanoSi catalyst support and to investigate the Pt thin film nanostructuration as well as the nanoparticle attachment and clustering processes, evidencing the controlling factors and conditions of the size, morphology and distribution. Furthermore, the experimental structures have been subjected to different electrochemical tests and it was revealed that significant improvement of the long term catalyst stability was achieved when the metal‐porous Si nanoassemblies is formed, which represents a step closer to the realisation of the monolithic integrated Si‐based microfabricated fuel cell.
Cognitive and default‐mode resting state networks: Do male and female brains “rest” differently?
Authors: Weissman‐Fogel Irit , Moayedi Massieh , Taylor Keri S. , Pope Geoff , Davis Karen D. 
Published: March 2010

AbstractVariability in human behavior related to sex is supported by neuroimaging studies showing differences in brain activation patterns during cognitive task performance. An emerging field is examining the human connectome, including networks of brain regions that are not only temporally‐correlated during different task conditions, but also networks that show highly correlated spontaneous activity during a task‐free state. Both task‐related and task‐free network activity has been associated with individual task performance and behavior under certain conditions. Therefore, our aim was to determine whether sex differences exist during a task‐free resting state for two networks associated with cognitive task performance (executive control network (ECN), salience network (SN)) and the default mode network (DMN). Forty‐nine healthy subjects (26 females, 23 males) underwent a 5‐min task‐free fMRI scan in a 3T MRI. An independent components analysis (ICA) was performed to identify the best‐fit IC for each network based on specific spatial nodes defined in previous studies. To determine the consistency of these networks across subjects we performed self‐organizing group‐level ICA analyses. There were no significant differences between sexes in the functional connectivity of the brain areas within the ECN, SN, or the DMN. These important findings highlight the robustness of intrinsic connectivity of these resting state networks and their similarity between sexes. Furthermore, our findings suggest that resting state fMRI studies do not need to be controlled for sex. Hum Brain Mapp, 2010. © 2010 Wiley‐Liss, Inc.
Necrotizing fasciitis of the head and neck
Authors: Wolf Henning , Rusan Maria , Lambertsen Karin , Ovesen Therese 
Published: March 2010

AbstractBackgroundNecrotizing fasciitis of the head and neck is a rapidly progressing and life‐threatening condition. The purpose of this study was to describe the patients with a focus on clinical presentation, microbiology, treatment, and prognosis.Patients and ResultsSeventeen patients (10 men; median age, 54 years) were included. Nine patients underwent minor head and neck surgery immediately prior to necrotizing fasciitis. The typical course was a quickly spreading erythema, pronounced tenderness, and severe pain. Imaging demonstrated diffuse swelling of the soft tissue, poorly differentiated dilated fat layers, and subcutaneous gas. All patients underwent surgical debridement within 2 days, and received broad‐spectrum antibiotics and hemodynamic support, hyperbaric oxygen, and immunoglobulin. All patients survived, although 12 of 17 suffered sequelae.ConclusionsEarly diagnosis is of utmost importance. Quickly spreading erythema and extreme pain in the affected area serve as red flags. With the current intensive multimodality regimen, the mortality was zero, although 70% suffered sequelae. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
Employee satisfaction with meetings: A contemporary facet of job satisfaction
Authors: Rogelberg Steven G. , Allen Joseph A. , Shanock Linda , Scott Cliff , Shuffler Marissa 
Published: March 2010

AbstractGiven the ubiquity, time investment, and theoretical relevance of meetings to work attitudes, this study explored whether organizational science should consider employee satisfaction with meetings as a contemporary, important, and discrete facet of job satisfaction. Using affective events theory, we postulated that meetings are affect‐generating events that meaningfully contribute to overall job satisfaction. Two surveys queried working adults: Study 1 used a paper‐based survey (n = 201), while Study 2 used an Internet‐based survey (n = 785). Satisfaction with meetings was positively related to and significantly predicted overall job satisfaction (p < .05) after controlling for individual difference variables (e.g., participant background variables, negative affect), traditional job satisfaction facets (e.g., work, supervision, pay), and other conceptually relevant constructs (e.g., satisfaction with communication, organizational commitment). Exploratory (Study 1) and confirmatory (Study 2) factor analyses provided evidence that meeting satisfaction is a distinct facet of job satisfaction. Finally, as hypothesized, the relationship between meeting satisfaction and job satisfaction depends in part upon the number of meetings typically attended. The relationship was stronger (more positive) when meeting demands were higher and weaker when meeting demands were lower. Implications for assessment, leadership development, on‐boarding, and high potential initiatives are discussed. ©2010 Wiley Periodicals, Inc.
Stock price reactions to GLBT nondiscrimination policies
Authors: Wang Peng , Schwarz Joshua L. 
Published: March 2010

AbstractThis study examines workplace issues of gay, lesbian, bisexual, and transgender (GLBT) employees. Specifically, we analyze the effect of firm GLBT nondiscrimination policies on that firm's stock market value. Corporate equality index (CEI) is used as a proxy for how firms manage GLBT issues. Results reveal that changes in firms' standardized CEI scores are positively associated with changes in firms' standardized stock price trend during the following year. Our findings suggest that the stock prices of firms with more progressive GLBT nondiscrimination policies relative to competing firms in the same industry outperform otherwise equivalent firms with lower CEI scores. © 2010 Wiley Periodicals, Inc.
High performance work systems in emergent organizations: Implications for firm performance
Authors: Messersmith Jake G. , Guthrie James P. 
Published: March 2010

AbstractEmerging firms are the foundation for economic growth in today's business world. Yet relatively little is known about the factors that contribute to the success or failure of developing organizations. This research study addresses this broad question by examining the role that high performance work systems (HPWS) play in the performance of high‐tech new ventures. Using the resource‐based and dynamic capability perspectives, this research project examines the links between HPWS and firm performance. Results indicate that HPWS utilization is positively associated with sales growth and innovation; however, a hypothesized mediating role for employee voluntary turn over was not supported. © 2010 Wiley Periodicals, Inc.