bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioresolution of five β‐blockers by reversed‐phase high‐performance liquid chromatography using fifteen chiral derivatizing reagents having amino acids or their amides as chiral auxiliaries on a cyanuric chloride platform
Authors: Bhushan Ravi , Dixit Shuchi 
Published: June 2011

ABSTRACTEnantioseparation of five β‐blockers, namely, (R,S)‐atenolol, (R,S)‐propranolol, (R,S)‐bisoprolol, (R,S)‐metoprolol and (R,S)‐carvedilol, was achieved as their diastereomers prepared with chiral derivatizing reagents (CDRs) synthesized on a cyanuric chloride platform. Fifteen CDRs were synthesized by nucleophilic substitution of the Cl atom in cyanuric chloride or its 6‐methoxy derivative with amino acids (namely, l‐Leu, l‐Val, d‐Phg, l‐Met and l‐Ala) or their amides as chiral auxiliaries. The diastereomers were synthesized under microwave irradiation for 70 or 100 s at 85% power. Separation of diastereomers was carried out on a C18 column and gradient eluting mixtures of methanol with aqueous trifluoroacetic acid with UV detection at 230 nm. Separation efficiencies of the reagents were compared on the basis of effect of chiral auxiliaries (i.e. amino acids or amino acid amides) and achiral substituents (i.e. chlorine or methoxy group) in the CDRs. The method was validated for detection limit, linearity, accuracy and precision. Copyright © 2011 John Wiley & Sons, Ltd.
Overcoming challenges in WAVE bioreactors without feedback controls for pH and dissolved oxygen
Authors: Yuk Inn H. , Baskar Dinesh , Duffy Philip H. , Hsiung Jenny , Leung Susan , Lin Andy A. 
Published: June 2011

AbstractThe biopharmaceutical industry is increasing its use of the WAVE Bioreactor for culturing cells. Although this disposable bioreactor can be equipped to provide real‐time pH and dissolved oxygen (DO) monitoring and control, our goal was to develop a process for culturing CHO cells in this system without relying on pH and DO feedback controls. After identifying challenges in culturing cells without controlling for pH and DO in the WAVE Bioreactor, we characterized O2 and CO2 transfer in the system. From these cell‐free studies, we identified rock rate and rock angle as key parameters affecting O2 transfer. We also identified the concentration of CO2 in the incoming gas and the rate of gas flow into the headspace as key parameters affecting CO2 transfer—and therefore pH—in the disposable culture chamber. Using a full‐factorial design to evaluate the rock rate, rock angle, and gas flow rate defined for this WAVE Bioreactor process, we found comparable cell growth and pH profiles in the ranges tested for these three parameters in two CHO cell lines. This process supported cell growth, and maintained pH and DO within our desired range—pH 6.8–7.2 and DO exceeding 20% of air saturation—for six CHO cell lines, and it also demonstrated comparable cell growth and viability with the stirred‐tank bioreactor process with online pH and DO control. By eliminating the use of pH and DO probes, this process provides a simple and more cost‐effective method for culturing cells in the WAVE Bioreactor. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Effect of codon optimization on the expression of Trichoderma reesei endoglucanase 1 in Pichia pastoris
Authors: Akcapinar Gunseli Bayram , Gul Ozgur , Sezerman Ugur 
Published: June 2011

AbstractTrichoderma reesei cellulases are important biocatalysts for a wide range of industrial applications that include the paper, feed, and textile industries. T. reesei endoglucanase 1 (egl1) was successfully expressed as an active and stable catalyst in Pichia pastoris for the first time. Codon optimization was applied to egl1 of T. reesei to enhance its expression levels in P. pastoris. When compared with the originally cloned egl1 gene of T. reesei, the synthetic codon optimized egl1 gene (egl1s) was expressed at a higher level in P. pastoris. Batch fermentations of both clones with the same copy number under controlled conditions indicated that codon optimized EGI enzyme activity increased to 1.24 fold after 72 h of methanol induction. Our research indicated that P. pastoris is a suitable host for cellulase production. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2011
Two‐stage percutaneous closure of mitral periprosthetic valvular leak
Authors: Hetherington Simon L. , Murphy Ross T. , Pate Gordon E. 
Published: June 2011

AbstractPeriprosthetic valve leak can develop as a complication of valve replacement surgery and may manifest as symptomatic valvular regurgitation, heart failure, or haemolysis. We report a case of severe mitral periprosthetic valve leak requiring a two‐stage percutaneous closure technique with multiple Amplatzer® III vascular plugs.© 2011 Wiley‐Liss, Inc.
Tunable Emission of Static Excimer in a Pyrene‐Modified Polyamidoamine Dendrimer Aggregate through Positive Solvatochromism
Authors: Lekha P. K. , Prasad Edamana 
Published: June 2011

AbstractSignificant aggregation is observed in pyrene‐modified zero‐ and first‐generation polyamidoamine (PAMAM) dendrimers above their critical aggregation concentration (CAC, >10−6 M). The pyrene units are attached to the dendrimer skeleton through imine bonds, which play a pivotal role in enhancing the aggregation propensity of the PAMAM dendrimers. Scanning electron microscopy studies suggest that pyrene‐modified PAMAM dendrimers aggregate into doughnut‐shaped assemblies. As a result of aggregation, the pyrene chromophores are pre‐arranged in a face‐to‐face geometry in the ground state, and readily generate pyrene “static excimer” on photoexcitation. The static pyrene excimer emits with an unprecedented quantum yield of 0.62±0.01 in dichloromethane, and also exhibits remarkable positive solvatochromism from 498 to 638 nm, which leads to the highest bathochromic shift for pyrene excimer emission in solution reported so far. Lippert–Mataga analysis of the system suggests that general and specific solvent effects play a crucial role in the positive solvatochromism exhibited by the system. Luminescence quenching studies on both monomer and aggregate systems were carried out in the presence of various metal ions, and the results imply that pyrene‐modified PAMAM dendrimer can be utilized for selective detection of Hg ions in the presence of a wide variety of transition, alkali, and alkaline earth metal ions. This report presents the first dendrimer‐based chromophoric system exhibiting positive solvatochromism over a range of 140 nm, and shows that pyrene‐modified PAMAM dendrimers can be effectively utilized to generate wavelength‐tunable emitting systems displaying bluish green, greenish yellow, and orange‐red colors at room temperatures.
ChemInform Abstract: Unusually Large Magnetic Anisotropy in a CuO‐Based Semiconductor Cu5V2O10.
Authors: He Zhangzhen , Lin Chensheng , Cheng Wendan , Okazawa Atsushi , Kojima Norimichi , Yamaura Jun‐ichi , Ueda Yutaka 
Published: June 2011

AbstractMagnetic measurements on single crystals of the title compound show that it exhibits an unexpected large magnetic anisotropy energy of up to 107 erg/cm3 at 5 K.
ChemInform Abstract: Ca3N2 and Mg3N2: Unpredicted High‐Pressure Behavior of Binary Nitrides.
Authors: Braun Cordula , Boerger Saskia L. , Boyko Teak D. , Miehe Gerhard , Ehrenberg Helmut , Hoehn Peter , Moewes Alexander , Schnick Wolfgang 
Published: June 2011

AbstractRed γ‐Ca3N2 is obtained from the ambient‐pressure α‐ and β‐phases at pressures of 8—18 GPa and 1000—1200 °C.
ChemInform Abstract: Short‐Range Layered A‐Site Ordering in Double Perovskites NaLaBB′O6 (B: Mn, Fe; B′: Nb, Ta).
Authors: Dachraoui Walid , Yang Tao , Liu Chang , King Graham , Hadermann Joke , Van Tendeloo Gustaaf , Llobet Anna , Greenblatt Martha 
Published: June 2011

AbstractThe new compounds NaLaFeTaO6, NaLaFeNbO6, NaLaMnTaO6, and NaLaMnNbO6 are synthesized by solid state reaction in air using La2O3, Na2CO3, Mn2O3/Fe2O3, and Nb2O5/Ta2O5 as starting materials (1350 °C, 120 h).
ChemInform Abstract: M3‐x(NH4)xCrO8 (M: Na, K, Rb, Cs): A New Family of Cr5+‐Based Magnetic Ferroelectrics.
Authors: Samantaray Raghabendra , Clark Ronald J. , Choi Eun S. , Zhou Haidong , Dalal Naresh S. 
Published: June 2011

AbstractThe new magnetic title compounds are synthesized by reaction of H2O2 with an ice‐cold solution of basic CrO3, alkali‐metal hydroxide, and NH4OH.
ChemInform Abstract: Hydrothermal Synthesis of Isostructural Open‐Framework Manganese and Iron Borophosphates: Effect of the Organic Templates in Determining the Pore Shapes.
Authors: Yang Weiting , Li Jiyang , Xu Jin , Xing Hongzhu , Wang Lei , Yu Jihong , Xu Ruren 
Published: June 2011

AbstractThe three new isostructural compounds (II) and (III) crystallize in the orthorhombic space group Ima2 with Z = 4 (single crystal XRD).
ChemInform Abstract: Solvothermal Syntheses and Crystal Structures of Two Thioarsenate Metal Complexes [Co(dien)2]3[As3S6]2 and [Mn(teta)]2As2S5.
Authors: Liu Xing , Zhou Jian 
Published: June 2011

AbstractCompounds (III) and (V) crystallize in the monoclinic space group P21/c with Z = 2 for (III) and Z = 4 for (V).
ChemInform Abstract: Bis(μ3‐iodo)‐pentakis(μ2‐iodo)‐penta‐copper (I) — A Fully Ordered, Isolated [Cu5I7]2‐ Cluster.
Authors: Jalilian Ehsan , Lidin Sven 
Published: June 2011

Abstract(Bu4P)2[Cu5I7] (I) and (Bu4P)2 [Cu5I7]·Me‐CO‐CH2OH (II) are synthesized by refluxing a mixture of Cu powder, iodine, and (Bu4P)I in hydroxyacetone.
ChemInform Abstract: Organocatalytic Functionalization of Carboxylic Acids: Isothiourea‐Catalyzed Asymmetric Intra‐ and Intermolecular Michael Addition—Lactonizations.
Authors: Belmessieri Dorine , Morrill Louis C. , Simal Carmen , Slawin Alexandra M. Z. , Smith Andrew D. 
Published: June 2011

AbstractThe intramolecular reaction of enone acids in the presence of tetramisole·HCl affords indene or dihydrobenzofuran carboxylates with up to 99% ds.
ChemInform Abstract: Pentanidium‐Catalyzed Enantioselective Phase‐Transfer Conjugate Addition Reactions.
Authors: Ma Ting , Fu Xiao , Kee Choon Wee , Zong Lili , Pan Yuanhang , Huang Kuo‐Wei , Tan Choon‐Hong 
Published: June 2011

AbstractPentanidium chloride (I) is found to be an excellent chiral phase‐transfer catalyst for the Michael addition reaction of Schiff base (II) with a variety of α,β‐unsaturated acceptors.
ChemInform Abstract: Gold‐Catalyzed Cyclizations: A Comparative Study of ortho,ortho′‐Substituted KITPHOS Monophosphines with Their Biaryl Monophosphine Counterpart SPHOS.
Authors: Hashmi A Stephen K. , Loos Annette , Doherty Simon , Knight Julian G. , Robson Katharine J. , Rominger Frank 
Published: June 2011

AbstractA new gold(I) complex is used as an efficient catalyst for intramolecular cycloisomerizations to afford benzopyran (II) and oxazoline (VI) in high yields.
ChemInform Abstract: Selective Photocatalytic Aerobic Bromination with Hydrogen Bromide via an Electron‐Transfer State of 9‐Mesityl‐10‐methylacridinium Ion.
Authors: Ohkubo Kei , Mizushima Kentaro , Iwata Ryosuke , Fukuzumi Shunichi 
Published: June 2011

AbstractPhotoinduced bromination of various aromatic compounds (I) is smoothly achieved with HBr using oxygen as terminal oxidant in the presence of N‐methyl mesitylacridinium ion.
ChemInform Abstract: Palladium‐Catalyzed α‐Ketone Arylation under Mild Conditions.
Authors: Cao Changsheng , Wang Lingling , Cai Zhengyuan , Zhang Lingqiao , Guo Jin , Pang Guangsheng , Shi Yanhui 
Published: June 2011

AbstractThe N‐heterocyclic carbene complex PAL displays high activity for activated, unactivated, and sterically hindered aryl chlorides and bromides in the reaction with aryl or alkyl ketones.
ChemInform Abstract: Nanocrystalline Copper(II) Oxide‐Catalyzed One‐Pot Synthesis of Imidazo[1,2‐a]quinoline and Quinolino[1,2‐a]quinazoline Derivatives via a Three‐Component Condensation.
Authors: Ahmadi Seyed Javad , Hosseinpour Morteza , Sadjadi Sodeh 
Published: June 2011

AbstractNanocrystalline copper(II) oxide is used as catalyst for the synthesis of 3 imidazo[1,2‐a]quinoline derivatives of type (IV) and 3 quinolino[1,2‐a]quinazoline derivatives of type (VI).
ChemInform Abstract: 1,2‐Addition of Phenylacetylene to Aldimines Catalyzed by InCl3/CuCl in Water under Barbier Conditions.
Authors: Prajapati Dipak , Sarma Rupam , Bhuyan Debajyoti , Hu Wenhao 
Published: June 2011

AbstractA simple procedure is developed for the synthesis of various propargylamines.
ChemInform Abstract: Direct Acetoxylation and Etherification of Anilides Using Phenyliodine Bis(trifluoroacetate).
Authors: Liu Huan , Wang Xuemin , Gu Yonghong 
Published: June 2011

AbstractReaction of a wide variety of anilides (I) and (VII) with acetic acid (II) or alcohols (V) in the system PIFA—BF3·OEt2 provides access towards the corresponding acetoxylation or alkoxylation products.
ChemInform Abstract: Hypervalent Phenyl‐λ3‐iodane‐mediated para‐Selective Aromatic Fluorination of 3‐Phenylpropyl Ethers.
Authors: Saito Motomichi , Miyamoto Kazunori , Ochiai Masahito 
Published: June 2011

AbstractExposure of 3‐phenylpropyl ethers (I) to an activated iodosyl‐benzene monomer 18‐crown‐6 complex in the presence of a Lewis acid and water results in the para‐selective monofluorination of the benzene ring via neighboring alkoxy group participation.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Suzuki Coupling of Benzyl Halides with Potassium Aryltrifluoroborates in Aqueous Media.
Authors: Wu Xiao‐Feng , Neumann Helfried , Beller Matthias 
Published: June 2011

AbstractVarious benzyl halides are converted into diarylethanones in the presence of carbon monoxide using different aryl trifluoroborates.
ChemInform Abstract: Unique Reactivity of Grignard Reagents Towards Cyclopropenyl‐Carboxylates — Highly Selective Carbon—Carbon Bond Cleavage.
Authors: Liu Yu , Ma Shengming 
Published: June 2011

AbstractReaction of cyclopropenyl dicarboxylates (I) and (XIII) with Grignard reagents proceeds chemoselectively with cyclopropene ring opening to give enedicarboxylates (III) and (XIV), resp., with excellent regio‐ and diastereoselectivity.
ChemInform Abstract: Dimethylsulfoxide‐Promoted Strecker Reaction of N‐Tosylaldimines with Cyanoformate.
Authors: Kadam Santosh T. , Thirupathi Ponnaboina , Kim Sung Soo 
Published: June 2011

AbstractA metal‐free, uncatalyzed Strecker reaction of N‐tosylaldimines (I) with ethyl cyanoformate (II) is developed.
ChemInform Abstract: Novel C—H Functionalization of Arenes: Palladium‐Catalyzed Synthesis of Diaryl Sulfides.
Authors: Anbarasan Pazhamalai , Neumann Helfried , Beller Matthias 
Published: June 2011

AbstractA novel protocol for the direct arylthiolation of arenes (I) applying arylsulfonyl cyanides (II) is described.
ChemInform Abstract: The Actual Active Species of Sulfur‐Modified Gold‐Supported Palladium as a Highly Effective Palladium Reservoir in the Suzuki—Miyaura Coupling.
Authors: Hoshiya Naoyuki , Shuto Satoshi , Arisawa Mitsuhiro 
Published: June 2011

AbstractThe reactions of (hetero)aryl and styryl iodides with phenylboronic acids proceed with nearly quantitative yields.
ChemInform Abstract: Suzuki Coupling Reactions in Pure Water Catalyzed by Supported Palladium — Relevance of the Surface Polarity of the Support.
Authors: Soomro Saeeda S. , Roehlich Christoph , Koehler Klaus 
Published: June 2011

AbstractHeterogeneous palladium catalysts are highly active for Suzuki coupling reactions in neat water and in the presence of tetrabutylammonium bromide under mild conditions.
ChemInform Abstract: An Efficient and General Iron‐Catalyzed C—C Bond Activation with 1,3‐Dicarbonyl Units as a Leaving Groups.
Authors: Li Huanrong , Li Wenjuan , Liu Weiping , He Zhiheng , Li Zhiping 
Published: June 2011

AbstractDiones such as (I) undergo a novel FeCl3‐catalyzed C—C bond cleavage to release carbocations which are treated with reactive arenes to afford the products of electrophilic aromatic substitution.
ChemInform Abstract: Microwave‐Assisted Nickel(II) Acetylacetonate‐Catalyzed Arylation of Aldehydes with Arylboronic Acids.
Authors: Chen Wen , Baghbanzadeh Mostafa , Kappe C. Oliver 
Published: June 2011

AbstractOptimized reaction conditions A) or B) are developed to give diarylmethanols or benzyl alcohols.
ChemInform Abstract: Bis(μ‐iodo)bis((‐)‐sparteine)dicopper(I) Catalyzed Sonogashira‐Type Reaction under Palladium and Phosphine‐Free Conditions.
Authors: Priyadarshini S. , Joseph P. J. Amal , Srinivas P. , Maheswaran H. , Kantam M. Lakshmi , Bhargava Suresh 
Published: June 2011

AbstractThe dicopper(I)‐complex is a versatile catalyst for the cross‐coupling of a broad spectrum of aryl halides, where the bromides are generally the most suitable ones.
ChemInform Abstract: Pd‐Catalyzed Coupling of β‐Hydroxy α‐Diazocarbonyl Compounds with Aryl Iodides: A Migratory Insertion/β‐Hydroxy Elimination Sequence.
Authors: Zhou Lei , Liu Yizhou , Zhang Yan , Wang Jianbo 
Published: June 2011

AbstractThe title reaction represents a new method for the synthesis of tetrasubstituted olefins.
ChemInform Abstract: A Novel Samarium(II)‐Mediated Tandem Spirocyclization onto an Aromatic Ring.
Authors: Iwasaki Hiroki , Tsutsui Nozomi , Eguchi Toru , Ohno Hiroaki , Yamashita Masayuki , Tanaka Tetsuaki 
Published: June 2011

AbstractThe synthesis proceeds via ketyl radical attack on the aromatic ring, single electron transfer, and nucleophilic attack of the resulting dienyl anion to the ester group.
ChemInform Abstract: Studies on Tetrahydrofuran‐Based Highly O‐Functionalized Alkynes: Applications to Synthesis of Tetrahydrofuranyl‐Polyynes and C‐Nucleoside Analogues.
Authors: Reddy P. Venkat , Bajpai Vikas , Kumar Brijesh , Shaw Arun K. 
Published: June 2011

AbstractThe synthesis of C‐alkynyl glycosides is best performed by treatment of the crude aldehydes derived from building blocks such as (I) with the Bestmann—Ohira compound (II).
ChemInform Abstract: A Novel α‐Isocyanoacetamide‐Based Three‐Component Reaction for the Synthesis of Dialkyl 2‐Acyl‐5‐aminofuran‐3,4‐dicarboxylates.
Authors: Mossetti Riccardo , Caprioglio Diego , Colombano Giampiero , Tron Gian Cesare , Pirali Tracey 
Published: June 2011

AbstractOne‐pot two‐step reaction of α‐isocyanoacetamides (I) with acyl chlorides (II) and acetylene dicarboxylates (III) provides access towards title aminofuran dicarboxylates (IV) in moderate yields.
ChemInform Abstract: Synthesis of Indenoindene‐Fused α‐Methylene‐γ‐butyrolactones via a Tandem Intra‐ and Intermolecular Friedel—Crafts Reaction.
Authors: Park Bo Ram , Kim Se Hee , Kim Yu Mi , Kim Jae Nyoung 
Published: June 2011

AbstractTreatment of spiro‐lactones (I) and (IV) with sulfuric acid affords the title compounds in a cycloaddition sequence.
ChemInform Abstract: Novel Methodologies for the Synthesis of Functionalized Pyroglutamates.
Authors: Tekkam Srinivas , Alam M. A. , Jonnalagadda Subash C. , Mereddy Venkatram R. 
Published: June 2011

AbstractA series of pyroglutamates (III), (VIII), and (X) is readily prepared by reaction of iminoesters (I) with corresponding Baylis—Hillman derivatives followed by acidic cleavage of imines and a subsequent lactamization.
ChemInform Abstract: Synthesis of Isoindole Derivatives by Palladium‐Catalyzed Domino Reaction of (2‐Alkynyl)phenylketone O‐Pentafluorobenzoyloximes.
Authors: Kitamura Mitsuru , Moriyasu Yohei , Okauchi Tatsuo 
Published: June 2011

AbstractThe importance of the o‐phenylene tether is found to be highly important for an efficient cyclization process.
ChemInform Abstract: Domino Sonogashira Coupling/Cyclization Reaction Catalyzed by Copper and ppb Levels of Palladium: A Concise Route to Indoles and Benzo[b]furans.
Authors: Wang Ruiping , Mo Song , Lu Yongzhong , Shen Zengming 
Published: June 2011

AbstractIt is shown that traces of palladium must be present to achieve good results, but no phosphine ligand is necessary.
ChemInform Abstract: Synthesis and Fungicidal Activity of 2‐Acetyl‐6‐(un)substituted‐1H‐benzimidazole Oxime‐ethers.
Authors: Jiang Lin , Wang Haibo , Mu Wei , Ji Jengchen , Cao Peng 
Published: June 2011

AbstractNew compounds (IIIa)—(IIId) show good activities against Botrytis cinerea, while compounds (IIIa), (IIIe) additionally exhibit excellent activities against Alternaria alternate.
ChemInform Abstract: Copper‐Catalyzed Direct Benzylation or Allylation of 1,3‐Azoles with N‐Tosylhydrazones.
Authors: Zhao Xia , Wu Guojiao , Zhang Yan , Wang Jianbo 
Published: June 2011

AbstractThe title reactions allow efficient access to 2‐benzylated/ allylated oxazoles, benzoxazoles, thiazoles, and benzothiazoles.
ChemInform Abstract: An Efficient and Stereoselective Cycloaddition of C‐Aryl and C‐Amido Nitrones to Dimethyl 2‐Benzylidenecyclopropane‐1,1‐dicarboxylate.
Authors: Tran Tung Q. , Diev Vyacheslav V. , Molchanov Alexander P. 
Published: June 2011

AbstractThe 1,3‐dipolar cycloaddition of benzylidenecyclopropanes (I) with nitrones gives spirocyclopropylisoxazolidines as single isomers in the absence of Lewis acid.
ChemInform Abstract: Caros′s Acid—Silica Gel‐Catalyzed One‐Pot Synthesis of 12‐Aryl‐8,9,10,12‐tetrahydrobenzo[a]xanthen‐11‐ones.
Authors: Karimi Narges , Oskooie Hossein Abdi , Heravi Majid M. , Tahershamsi Leila 
Published: June 2011

AbstractA simple three‐component synthesis of the title compounds (IV) including an easy work‐up and the use of a inexpensive, nontoxic and easily available catalyst is described.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Cross‐Coupling Between Pyridine N‐Oxides and Indoles.
Authors: Gong Xue , Song Guoyong , Zhang Hong , Li Xingwei 
Published: June 2011

AbstractA variety of pyridine‐oxides undergoes a Pd‐catalyzed oxidative coupling with substituted indoles at the 3‐position.
ChemInform Abstract: Aqueous Suspension of Basic Alumina: An Efficient Catalytic System for the Synthesis of Poly Functionalized Pyridines
Authors: Shinde Pravin V. , Shingate Bapurao B. , Shingare Murlidhar S. 
Published: June 2011

Abstractvia one‐pot, three‐component condensation of aromatic aldehydes (I), malononitrile (II), and thiophenols (III)
ChemInform Abstract: Efficient Synthesis of 1,3,5‐Trisubstituted Benzenes via Three Pd‐Mediated Carbon—Sulfur, Carbon—Nitrogen and Carbon—Carbon Bond Formation Reactions.
Authors: Liu Bin , Shetty Rupa S. , Moffett Kristofer K. , Kelly Martha J. 
Published: June 2011

AbstractVarious types of title compounds are prepared starting from dichloride (I).
ChemInform Abstract: An Approach to Highly Functionalized Quinolines and Isoquinolines via a Gold‐Catalyzed Benzannulation.
Authors: Panda Biswajit , Bhadra Jhuma , Sarkar Tarun K. 
Published: June 2011

AbstractPyridine derived o‐alkynyl‐substituted aldehydes readily react with internal and terminal alkynes to yield the target compounds in a regioselective fashion.
ChemInform Abstract: A One‐Pot, Three‐Component Approach to Functionalized Tetrahydroisoquinolines Using Domino Heck‐aza‐Michael Reactions.
Authors: Priebbenow Daniel L. , Pfeffer Frederick M. , Stewart Scott G. 
Published: June 2011

AbstractThe generation of acrylamides followed by domino Heck—aza‐Michael reaction represents a novel synthetic pathway to tetrahydroisoquinolines bearing a C1‐acetamide functionality (IV), (VI), (VIII) and (IX).
ChemInform Abstract: A General Approach to N‐Heterocyclic Scaffolds Using Domino Heck—aza‐Michael Reactions.
Authors: Priebbenow Daniel L. , Stewart Scott G. , Pfeffer Frederick M. 
Published: June 2011

AbstractPalladium‐catalyzed domino Heck—aza‐Michael reaction of o‐bromophenylalkylamines (I) and (VI) with electron‐deficient olefins (II) provides access to tetrahydroisoquinolines (III) and isoindolines (VII), resp., in good yields.
ChemInform Abstract: Unexpected Synthesis of Indolo[1,2‐c]quinazolines by a Sequential Ugi 4CC—Staudinger—aza‐Wittig—Nucleophilic Addition Reaction.
Authors: He Ping , Nie Yi‐Bo , Wu Jing , Ding Ming‐Wu 
Published: June 2011

AbstractUgi reaction of o‐azidobenzaldehyde (I) with o‐acylaniline (II), a carboxylic acid and an isonitrile provides the product (V).