bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stable Cycling of All-Solid-State Lithium Batteries Enabled by Cyano-Molecular Diamond Improved Polymer Electrolytes
Authors: Dai Yang , Zhuang Mengbing , Deng Yi-Xiao , Liao Yuan , Gu Jian , Song Tinglu , Yan Hao , Zheng Jin-Cheng 
Published: June 2024

AbstractThe interfacial instability of the poly(ethylene oxide) (PEO)-based electrolytes impedes the long-term cycling and further application of all-solid-state lithium metal batteries. In this work, we have shown an effective additive 1-adamantanecarbonitrile, which contributes to the excellent performance of the poly(ethylene oxide)-based electrolytes. Owing to the strong interaction of the 1-Adamantanecarbonitrile to the polymer matrix and anions, the coordination of the Li+-EO is weakened, and the binding effect of anions is strengthened, thereby improving the Li+ conductivity and the electrochemical stability. The diamond building block on the surface of the lithium anode can suppress the growth of lithium dendrites. Importantly, the 1-Adamantanecarbonitrile also regulates the formation of LiF in the solid electrolyte interface and cathode electrolyte interface, which contributes to the interfacial stability (especially at high voltages) and protects the electrodes, enabling all-solid-state batteries to cycle at high voltages for long periods of time. Therefore, the Li/Li symmetric cell undergoes long-term lithium plating/stripping for more than 2000 h. 1-Adamantanecarbonitrile-poly(ethylene oxide)-based LFP/Li and 4.3 V Ni0.8Mn0.1Co0.1O2/Li all-solid-state batteries achieved stable cycles for 1000 times, with capacity retention rates reaching 85% and 80%, respectively.
Tree-Inspired Structurally Graded Aerogel with Synergistic Water, Salt, and Thermal Transport for High-Salinity Solar-Powered Evaporation
Authors: Zhao Xiaomeng , Zhang Heng , Chan Kit-Ying , Huang Xinyue , Yang Yunfei , Shen Xi 
Published: June 2024

Abstract
Solar-powered interfacial evaporation is an energy-efficient solution for water scarcity. It requires solar absorbers to facilitate upward water transport and limit the heat to the surface for efficient evaporation. Furthermore, downward salt ion transport is also desired to prevent salt accumulation. However, achieving simultaneously fast water uptake, downward salt transport, and heat localization is challenging due to highly coupled water, mass, and thermal transport. Here, we develop a structurally graded aerogel inspired by tree transport systems to collectively optimize water, salt, and thermal transport. The arched aerogel features root-like, fan-shaped microchannels for rapid water uptake and downward salt diffusion, and horizontally aligned pores near the surface for heat localization through maximizing solar absorption and minimizing conductive heat loss. These structural characteristics gave rise to consistent evaporation rates of 2.09 kg m−2 h−1 under one-sun illumination in a 3.5 wt% NaCl solution for 7 days without degradation. Even in a high-salinity solution of 20 wt% NaCl, the evaporation rates maintained stable at 1.94 kg m−2 h−1 for 8 h without salt crystal formation. This work offers a novel microstructural design to address the complex interplay of water, salt, and thermal transport.
Photoisomerization pathway of the microbial rhodopsin chromophore in solution
Authors: Sugiura Masahiro , Kandori Hideki 
Published: June 2024

AbstractPhotoisomerization is a key photochemical reaction in microbial and animal rhodopsins. It is well established that such photoisomerization is highly selective; all-trans to 13-cis, and 11-cis to all-trans forms in microbial and animal rhodopsins, respectively. Nevertheless, unusual photoisomerization pathways have been discovered recently in microbial rhodopsins. In an enzymerhodopsin NeoR, the all-trans chromophore is isomerized into the 7-cis form exclusively, which is stable at room temperature. Although, the 7-cis form is produced by illumination of retinal, formation of the 7-cis form was never reported for a protonated Schiff base of all-trans retinal in solution. Present HPLC analysis of retinal oximes prepared by hydroxylamine reaction revealed that all-trans and 7-cis forms cannot be separated from the syn peaks under the standard HPLC conditions, while it is possible by the analysis of the anti-peaks. Consequently, we found formation of the 7-cis form by the photoreaction of all-trans chromophore in solution, regardless of the protonation state of the Schiff base. Upon light absorption of all-trans protonated retinal Schiff base in solution, excited-state relaxation accompanies double-bond isomerization, producing 7-cis, 9-cis, 11-cis, or 13-cis form. In contrast, specific chromophore-protein interaction enforces selective isomerization into the 13-cis form in many microbial rhodopsins, but into 7-cis in NeoR.
Graphical Abstract
Active Community-Based Case Finding of Endemic Leishmaniasis in West Bengal, India
Authors: Guha Subhasish Kamal , Sardar Ashif Ali , Misra Amartya Kumar , Saha Pabitra , Samanta Anwesha , Maji Dipankar , Mandal Amitabha , Saha Punita , Halder Supriya , Ali Kabiul Akhter , Karmakar Sibajyoti , Sharma Dipendra , Maji Ardhendu Kumar 
Published: June 2024

Abstract
Introduction
The ongoing visceral leishmaniasis (VL) elimination programme in India is targeting the elimination of the disease VL but not the pathogen. The persistence of hidden parasite pool may initiate a resurgence in suitable conditions. This study dealt with a novel approach to unearth such pathogen pool and their proper management to prevent the resurgence of VL.

Materials and Methods
We deployed a new approach for detection of pathogen pool by following up the VL and post kala-azar dermal leishmaniasis patients treated during the last 10 years along with mass sero-surveillance within a radius of 500 m of recently treated individuals.

Results
We followed up 72.6% (3026/4168) previously treated VL and post kala-azar dermal leishmaniasis patients and diagnosed 42 (1.4%) new and 38 (1.3%) recurrent post kala-azar dermal leishmaniasis. We detected 93 asymptomatic leishmanial infection, 8 VL and 1 post kala-azar dermal leishmaniasis by mass sero-surveillance.

Conclusion
Our three-step process including mapping and follow-up of previously treated cases, mass surveillance within 500 m of radius of known cases, and 6 monthly follow-on clinical and serological screening of asymptomatic cases, enabled detection of previously undetected cases of post kala-azar dermal leishmaniasis and VL. Recurrent post kala-azar dermal leishmaniasis deserves special attention regarding their treatment guideline. Early diagnosis and effective treatment of all leishmaniasis cases will hasten pathogen elimination and prevent resurgence of VL. This may help the policymakers to develop appropriate strategy for elimination of pathogen to prevent resurgence of VL.
Seasonal Variations, Origin, and Parameterization of Ice‐Nucleating Particles at a Mountain Station in Central France
Authors: Bras Yannick , Freney Evelyn , Canzi Antoine , Amato Pierre , Bouvier Laetitia , Pichon Jean‐Marc , Picard David , Minguillón María Cruz , Pérez Noemí , Sellegri Karine 
Published: June 2024

AbstractIdentifying how aerosol particles interact with atmospheric water is critical to understand climate and precipitation. Ice‐nucleating particles (INP) trigger the formation of atmospheric ice crystals at higher temperatures than pure water. They are difficult to characterize because of their scarce occurrence, and variability, in the atmosphere, especially at temperatures above −20°C. It has been demonstrated that at these temperatures, biological aerosol particles can contribute significantly to INP number concentration. This study incorporates a series of offline, size‐segregated measurements of INPs collected at the Puy de Dôme station (PUY, 1,465 m a.s.l.) over a 6 month period from October to May, covering the transitions from autumn, winter, to spring. These measurements show a general trend of decreasing particle number concentrations during the winter months and higher concentration during autumn and spring. INP concentrations measured in the range of −5 and −18°C, had concentrations of 0.001 INP/Lair at the warmest temperatures, and between 0.01 and 0.1 INP/Lair at the coldest temperatures. The majority of INP measured at temperatures warmer than −15°C were heat labile, suggesting a biological or organic origin. The INP variability was compared with collocated aerosol physical and chemical properties, allowing us to associate highest INP concentrations with local and marine origins. Following these comparisons, we use aerosol total number concentration to develop a new parameterization. In addition, this parameterization is specifically optimized for warmer temperature INP measurements, and demonstrated a good performance when tested on independent data sets.
Kinetic Isotope Effects During Reduction of Fe(III) to Fe(II): Large Normal and Inverse Isotope Effects for Abiotic Reduction and Smaller Fractionations by Phytoplankton in Culture
Authors: John S. G. , Boyle E. A. , Cunningham B. R. , Fu F.‐X. , Greene S. , Hodierne C. , Hutchins D. A. , Kavner A. , King A. L. , Rosenberg A. D. , Saito M. A. , Wasson A. 
Published: June 2024

AbstractIron stable isotopes (δ56Fe) are a useful tool for studying Earth processes, many of which involve redox transformations between Fe(III) and Fe(II). Here, we present two related experimental efforts, a study of the kinetic isotope effects (KIEs) associated with the reduction of Fe(III)‐ethylenediaminetetraacetic acid (EDTA) to Fe(II), and measurements of the biological fractionation of Fe isotopes by phytoplankton in culture. Reductants tested were ascorbate, hydroxylamine, Mn(II), dithionite, and photoreduction at pH between 5 and 9 and temperatures from 0 to 100°C. Isotope fractionations were very large, and included both normal and inverse KIEs, ranging from −4‰ to +5‰. Experiments were reproducible, yielding similar results for triplicate experiments run concurrently and for experiments run weeks apart. However, fractionations were not predictable, without a clear relationship to reaction rate, temperature, pH, or the reductant used. Acquisition of Fe by eukaryotic phytoplankton also often involves the reduction of Fe(III) to Fe(II). Several species of diatoms and a coccolithophore were tested for Fe isotope fractionation in culture using EDTA, NTA, and DFB as Fe(III) chelating ligands, yielding fractionations from −1.3‰ to +0.6‰. Biological isotope effects were also unpredictable, showing no clear relationship to species, growth rate, or Fe concentration. Variability in Fe isotope fractionation observed in culture may be explained in part by the sensitivity of KIEs. This work has implications for the industrial purification of isotopes, interpretation of natural δ56Fe, and the use of Fe isotopes as a tracer Fe source and biological processes in the ocean and other natural systems.
A Global Paleosecular Variation Database for the Paleogene: Stationary Secular Variation Behavior Since the Triassic?
Authors: Engbers Y. A. , Thallner D. , Bono R. K. , Sprain C. J. , Murray M. J. , Bristol K. , Handford B. , Torsvik T. , Biggin A. J. 
Published: June 2024

AbstractPaleosecular variation analysis is a primary tool for characterizing ancient geomagnetic behavior and its evolution through time. This study presents a new high‐quality directional data set, paleosecular variation of the Paleogene (PSVP), with and without correction for serial correlation, compiled from 1,667 sites from 45 different localities from the Paleogene and late Cretaceous (84–23 Ma). The data set is used to study the variability, structure, and latitude dependence of the geomagnetic field during that period by varying selection criteria and PSV models. Modeled values for the equatorial virtual geomagnetic pole (VGP) dispersion have over‐lapping uncertainty intervals within their uncertainty bounds between 8.3° and 18.6° for the past 250 Ma. We investigate the suitability of two descriptive models of PSV, Model G‐style quadratic fits and covariant Giant Gaussian Process models, and find that both styles of model fail to satisfactorily reproduce the latitude dependent morphology of PSV, but suggest that estimates of the equatorial VGP dispersion may still robustly characterize aspects of Earth's long‐term field morphology. During this time where the PSV behavior has not changed substantially, the reversal frequency has varied widely. The lack of a clear relationship between PSV behavior and reversal frequency is not trivially explained in the context of published findings regarding numerical geodynamo simulations.
Effect of Al‐Incorporation on the Sound Velocities of Superhydrous Phase B at High Pressure and High Temperature
Authors: Xu Chaowen , Gréaux Steeve , Li Ying , Sun Fengxia , Gao Jing , Qin Fei , Inoue Toru 
Published: June 2024

AbstractSound velocities and densities of Al‐bearing superhydrous phase B (Al‐bearing SuB) were investigated up to 24 GPa and 1300 K by synchrotron X‐rays combined with ultrasonic interferometry techniques in a multi‐anvil apparatus. We found that Al + H incorporation decreases the adiabatic bulk modulus and shear modulus of SuB. Our results however suggest that this effect is less important than that of temperature. The presence of hydrous pyrolite with ∼10 wt.% Al‐bearing SuB in cold subducting slabs could explain up to ∼2% high velocity anomalies at the bottom of the mantle transition zone (500–660 km) while it turns into ∼7.7% low velocity anomalies below 660 km. Al‐bearing SuB is reportedly stable at mantle temperatures, where it could account for ∼12.2% low velocity anomalies beneath subduction zones in the uppermost lower mantle.
The Decline in Summer Fallow in the Northern Great Plains Cooled Near‐Surface Climate but had Minimal Impacts on Precipitation
Authors: Stoy P. C. , Bromley G. T. , Prein A. F. , Albeke S. E. 
Published: June 2024

AbstractLand management can moderate or intensify the impacts of a warming atmosphere. Since the early 1980s, nearly 116,000 km2 of cropland that was once held in fallow during the summer is now planted in the northern North American Great Plains. To simulate the impacts of this substantial land cover change on regional climate processes, convection‐permitting model experiments using the Weather Research and Forecasting model were performed to simulate modern and historical amounts of summer fallow. The control simulation was extensively validated using multiple observational data products as well as eddy covariance tower observations. Results of these simulations show that the transition from summer fallow to modern land cover led to ∼1.5°C cooler temperatures and decreased vapor pressure deficit by ∼0.15 kPa during the growing season across the study region, which is consistent with observed cooling trends. The cooler and wetter land surface with vegetation led to a shallower planetary boundary layer and lower lifted condensation level, creating conditions more conducive to convective cloud formation and precipitation. Our model simulations however show little widespread evidence of land surface changes effects on precipitation. The observed precipitation increase in this region is more likely related to increased moisture transport by way of the Great Plains Low Level Jet as revealed by the ERA5 reanalysis. Our results demonstrate that land cover change is consistent with observed regional cooling in the northern North American Great Plains but changes in precipitation cannot be explained by land management alone.
The Generic Mapping Tools and Animations for the Masses
Authors: Wessel P. , Esteban F. , Delaviel‐Anger G. 
Published: June 2024

AbstractGeneric Mapping Tools (GMT) is a well‐known set of software originally developed for geosciences, allowing scientists in climate and solid earth disciplines to routinely create publish‐ready maps and graphics. However, GMT users rarely make animations despite their undeniable benefit for understanding and teaching dynamic processes. As reading habits shift from print to digital, capitalizing on animations for illustrating scientific concepts is more accessible than ever. In the latest GMT version (6.5), we have added and refined the movie‐making modules, alleviating the time‐consuming steps that would hinder GMT users from making such animations. In this paper, we will explain how GMT's “movie” module works and provide six representative examples, from basic to more advanced, to show some of its key features. We hope our presentation will encourage the masses to routinely create animations for their publications.
The Origin of Jupiter's Great Red Spot
Authors: Sánchez‐Lavega Agustín , García‐Melendo Enrique , Legarreta Jon , Miró Arnau , Soria Manel , Ahrens‐Velásquez Kevin 
Published: June 2024

AbstractJupiter's Great Red Spot (GRS) is the largest and longest‐lived known vortex of all solar system planets but its lifetime is debated and its formation mechanism remains hidden. G. D. Cassini discovered in 1665 the presence of a dark oval at the GRS latitude, known as the “Permanent Spot” (PS) that was observed until 1713. We show from historical observations of its size evolution and motions that PS is unlikely to correspond to the current GRS, that was first observed in 1831. Numerical simulations rule out that the GRS formed by the merging of vortices or by a superstorm, but most likely formed from a flow disturbance between the two opposed Jovian zonal jets north and south of it. If so, the early GRS should have had a low tangential velocity so that its rotation velocity has increased over time as it has shrunk.
Expert consensus on endodontic therapy for patients with systemic conditions
Authors: Xu Xin , Zheng Xin , Lin Fei , Yu Qing , Hou Benxiang , Chen Zhi , Wei Xi , Qiu Lihong , Wenxia Chen , Li Jiyao , Chen Lili , Wang Zuomin , Wu Hongkun , Lu Zhiyue , Zhao Jizhi , Liang Yuhong , Zhao Jin , Pan Yihuai , Pan Shuang , Wang Xiaoyan , Yang Deqin , Ren Yanfang , Yue Lin , Zhou Xuedong 
Published: June 2024

AbstractThe overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. A systemic consideration of the patient’s overall health along with oral conditions holds the utmost importance in determining the necessity and feasibility of endodontic therapy, as well as selecting appropriate therapeutic approaches. This expert consensus is a collaborative effort by specialists from endodontics and clinical physicians across the nation based on the current clinical evidence, aiming to provide general guidance on clinical procedures, improve patient safety and enhance clinical outcomes of endodontic therapy in patients with compromised overall health.
Impact of structural biology and the protein data bank on us fda new drug approvals of low molecular weight antineoplastic agents 2019–2023
Authors: Burley Stephen K. , Wu-Wu Amy , Dutta Shuchismita , Ganesan Shridar , Zheng Steven X. F. 
Published: June 2024

AbstractOpen access to three-dimensional atomic-level biostructure information from the Protein Data Bank (PDB) facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023. Analyses of PDB holdings, the scientific literature, and related documents for each drug-target combination revealed that the impact of structural biologists and public-domain 3D biostructure data was broad and substantial, ranging from understanding target biology (100% of all drug targets), to identifying a given target as likely druggable (100% of all targets), to structure-guided drug discovery (>80% of all new small-molecule drugs, made up of 50% confirmed and >30% probable cases). In addition to aggregate impact assessments, illustrative case studies are presented for six first-in-class small-molecule anti-cancer drugs, including a selective inhibitor of nuclear export targeting Exportin 1 (selinexor, Xpovio), an ATP-competitive CSF-1R receptor tyrosine kinase inhibitor (pexidartinib,Turalia), a non-ATP-competitive inhibitor of the BCR-Abl fusion protein targeting the myristoyl binding pocket within the kinase catalytic domain of Abl (asciminib, Scemblix), a covalently-acting G12C KRAS inhibitor (sotorasib, Lumakras or Lumykras), an EZH2 methyltransferase inhibitor (tazemostat, Tazverik), and an agent targeting the basic-Helix-Loop-Helix transcription factor HIF-2α (belzutifan, Welireg).
Addressing gaps and enhancing experiences in support services for families of pediatric cancer survivors
Authors: Paul Verena , Inhestern Laura , Sigmund Désirée , Winzig Jana , Rutkowski Stefan , Escherich Gabriele , Bergelt Corinna 
Published: June 2024

Abstract
Background
Childhood cancer’s enduring challenges extend beyond primary therapy. Diverse medical and psychosocial services are available to assist families in follow-up care. This interview study sought to gain a thorough understanding of family motives, satisfaction levels, and barriers to utilization.

Methods
The design of this cross-sectional study involves a qualitative content analysis of semi-structured interviews. We interviewed parents of minor cancer survivors within the first 5 years after primary treatment.

Results
Survivors readily accessed medical support services when necessary. While parents expressed overall satisfaction with the available services, there was a notable gap in their knowledge regarding appropriate psychosocial and family-orientated services. Barriers to access included geographical distances, time constraints, and the absence of childcare options.

Conclusion
There are familial challenges and burdens that fall outside the scope of conventional care services. Tailoring services to family-centered needs, providing more information and easier access to interventions might help to reduce barriers.

Impact

Existing need notwithstanding, families did not frequently utilize psychosocial services as they did medical ones.

Identified barriers included lack of awareness, limited availability, long distances, and scheduling conflicts.

While many studies primarily focus on adult patients or young adults, the present study examines the gaps and strengths in follow-up care for pediatric cancer survivors and their families.

By acknowledging and addressing the unique challenges and strengths of families with pediatric cancer survivors, we can lead to a more tailored and effective follow-up approach that can enhance their overall well-being by minimizing barriers and providing targeted support.