bluuebunny/crossref_metadata_2025_split huggingface dataset:
FDA Approval Summary: Repotrectinib for Locally Advanced or Metastatic ROS1-Positive Non–Small Cell Lung Cancer
Authors: Barbato Michael I. , Bradford Diana , Ren Yi , Aungst Stephanie L. , Miller Claudia P. , Pan Lili , Zirkelbach Jeanne F. , Li Yangbing , Bi Youwei , Fan Jianghong , Grimstein Manuela , Dorff Sarah E. , Amatya Anup K. , Mishra-Kalyani Pallavi S. , Scepura Barbara , Schotland Peter , Udoka Opeyemi , Ojofeitimi Idara , Leighton John K. , Rahman Nam A. , Pazdur Richard , Singh Harpreet , Kluetz Paul G. , Drezner Nicole 
Published: June 2024

Abstract
On November 15, 2023, the U.S. Food and Drug Administration (FDA) granted traditional approval to repotrectinib (Augtyro, Bristol Myers Squibb Corporation) for the treatment of adult patients with locally advanced or metastatic receptor tyrosine kinase encoded by the ROS1 gene (ROS1)-positive non–small cell lung cancer (NSCLC). The approval was based on TRIDENT-1, a single-arm trial with multiple cohorts of patients with ROS1 fusion-positive (hereafter “ROS1-positive”) NSCLC (NCT03093116), who were either treatment naïve or had received prior ROS1 tyrosine kinase inhibitor (TKI) and/or platinum-based chemotherapy. The primary efficacy outcome measure is objective response rate (ORR) assessed by blinded independent central review (BICR) using response evaluation criteria in solid tumors version 1.1. ORR was assessed in 71 patients who were ROS1 TKI naïve and 56 patients who had received a prior ROS1 TKI. Among the 71 patients who were ROS1 TKI naïve, the ORR was 79% (95% CI, 68–88), median duration of response was 34.1 months (95% CI, 26–NE). In patients who had received a prior ROS1 TKI and no prior chemotherapy, the ORR was 38% (95% CI, 25–52). The median duration of response was 14.8 months (95% CI, 7.6–NE); BICR-assessed responses were observed in CNS metastases in patients in both cohorts and in patients who developed resistance mutations following prior TKI therapy. The most common (&gt;20%) adverse reactions were dizziness, dysgeusia, peripheral neuropathy, constipation, dyspnea, ataxia, fatigue, cognitive disorders, and muscular weakness. A unique feature of this ROS1 TKI approval is the inclusion of robust evidence of efficacy in patients with ROS1-positive NSCLC who had progressed on prior ROS1 TKIs.
Characterization of Pinilisa Dance Using the Dance Protocol as Performed by A Local Community in Isabela
Authors: Guado Mark Jason D. 
Published: June 2024

This study aimed to characterize the Pinilisa dance using the dance protocol as performed by a local community in Isabela and to create instructional materials as well as to improve the Pinilisa dance movement. Using ethnographic and narrative inquiry in the data gathering through a Focus Group Discussion (FGD), observation, structured interview guide, and documentation, this study documented, notated, and analyzed the Pinilisa dance as a reflection of the Ilocano culture, as well as the costumes, props, accessories, movement or dance pattern, dance notation, staging (formation) and performance, music notation, and sequencing to facilitate the development of supplemental instructional materials in teaching folk dance in Grade 7 Physical Education subject. This study's key informants were the residents and government employees of Jones, Isabela who are knowledgeable about the Pinilisa dance, including the municipal vice-mayor, municipal administrator, tourism officer, festival organizer, selected Local Government Units (LGUs), choreographers, and PE teachers. This study revealed that Pinilisa dance is an expression of Ilocano culture emphasizing five aspects: political, social, physical, economic, and religious. It is a dance that celebrates the abundant harvest of Pinilisa rice, from planting and harvesting to selling, honoring its people and expressing gratitude for the year's abundant crop. It embodies the Ilocano values of being hard-working, industrious, family-oriented, bayanihan, cheerful, resilient, and God-fearing, which reflects the people of Jones. The instructional materials in which the documented Pinilisa dance is an input for significant use in PE class in Grade 7, particularly in teaching folk dance. It is an additional instrument for uplifting, preserving, and promoting Jones, Isabela's cultural heritage.
Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension
Authors: Zhang Qi , Yaoita Nobuhiro , Tabuchi Arata , Liu Shaofei , Chen Shiau-Haln , Li Qiuhua , Hegemann Niklas , Li Caihong , Rodor Julie , Timm Sara , Laban Hebatullah , Finkel Toren , Stevens Troy , Alvarez Diego F. , Erfinanda Lasti , de Perrot Marc , Kucherenko Mariya M. , Knosalla Christoph , Ochs Matthias , Dimmeler Stefanie , Korff Thomas , Verma Subodh , Baker Andrew H. , Kuebler Wolfgang M. 
Published: June 2024

BACKGROUND:
Endothelial cell (EC) apoptosis and proliferation of apoptosis-resistant cells is a hallmark of pulmonary hypertension (PH). Yet, why some ECs die and others proliferate and how this contributes to vascular remodeling is unclear. We hypothesized that this differential response may: (1) relate to different EC subsets, namely pulmonary artery (PAECs) versus microvascular ECs (MVECs); (2) be attributable to autophagic activation in both EC subtypes; and (3) cause replacement of MVECs by PAECs with subsequent distal vessel muscularization.

METHODS:

EC subset responses to chronic hypoxia were assessed by single-cell RNA sequencing of murine lungs. Proliferative versus apoptotic responses, activation, and role of autophagy were assessed in human and rat PAECs and MVECs, and in precision-cut lung slices of wild-type mice or mice with endothelial deficiency in the autophagy-related gene 7 (
Atg7
EN-KO
). Abundance of PAECs versus MVECs in precapillary microvessels was assessed in lung tissue from patients with PH and animal models on the basis of structural or surface markers.

RESULTS:

In vitro and in vivo, PAECs proliferated in response to hypoxia, whereas MVECs underwent apoptosis. Single-cell RNA sequencing analyses support these findings in that hypoxia induced an antiapoptotic, proliferative phenotype in arterial ECs, whereas capillary ECs showed a propensity for cell death. These distinct responses were prevented in hypoxic
Atg7
EN-KO
mice or after
ATG7
silencing, yet replicated by autophagy stimulation. In lung tissue from mice, rats, or patients with PH, the abundance of PAECs in precapillary arterioles was increased, and that of MVECs reduced relative to controls, indicating replacement of microvascular by macrovascular ECs. EC replacement was prevented by genetic or pharmacological inhibition of autophagy in vivo. Conditioned medium from hypoxic PAECs yet not MVECs promoted pulmonary artery smooth muscle cell proliferation and migration in a platelet-derived growth factor–dependent manner. Autophagy inhibition attenuated PH development and distal vessel muscularization in preclinical models.

CONCLUSIONS:
Autophagic activation by hypoxia induces in parallel PAEC proliferation and MVEC apoptosis. These differential responses cause a progressive replacement of MVECs by PAECs in precapillary pulmonary arterioles, thus providing a macrovascular context that in turn promotes pulmonary artery smooth muscle cell proliferation and migration, ultimately driving distal vessel muscularization and the development of PH.
English Private Money, 1648–1672
Authors: Monter William 
Published: June 2024

Abstract
Between 1644 and 1672, England halted the production of its lowest denomination coins, prompting ordinary individuals and communities to create coins to address the shortage of small change. A large twentieth-century collection that includes over 13,000 such surviving tokens has largely been overlooked by historians and economists, despite the tokens’ significance. In this source and others are a total of over 9,000 types of tokens, originating mainly from the City of London, thirty-seven English counties, and the Irish Pale. Catalogued in an eight-volume Sylloge, published over thirty years, the tokens offer valuable insights into England’s history and societal dynamics during a tumultuous period that included two major regime changes, plague, and London’s Great Fire.
What Does the Surfer Know That Confucius Doesn’t?: Zhuangzian Skill Stories and Hawaiian Epistemology
Authors: Morrow Sydney 
Published: June 2024

Abstract
In her chapter “Models of knowledge in the Zhuangzi: Knowing with chisels and sticks,” Karyn L. Lai ponders Confucius’s conversation with the cicada catcher in the Zhuangzi. Lai asks, “What does the cicada catcher know that Confucius doesn’t?” The knowledge that Confucius and his disciples seek may be precisely what they can never have. I explore the epistemological rift between ways of knowing by applying Karen Amimoto Ingersoll’s distinction between “seascape epistemology” (based on Native Hawaiian, Kānaka Maoli, ways of knowing) and Western epistemology (framed as girding neocolonialist expansion on the Hawaiian Islands).
Comparative Philosophy and Practical Applied Ethics
Authors: Sullivan Laura Specker 
Published: June 2024

Abstract
Comparative philosophy is gaining traction in professional academic philosophy, with specialist journals, organizations, books, and public campaigns. These inroads have been made in canonical areas of philosophy, including epistemology, metaphysics, logic, and value theory. Yet comparative philosophy still plays little role in practical applied ethics, an interdisciplinary research area in which work with practice and policy implications are dominated by the anglophone world. In this article, I explain why comparative work might be especially difficult in this type of applied ethics, and I suggest how comparative philosophers might overcome these challenges to connect their theoretical work with contemporary practical issues.
Unveiling novel and known Cryptaphelenchus species from China and USA
Authors: Gu Jianfeng , Castillo Pablo , Ma Xinxin , Munawar Maria 
Published: June 2024

Summary
Cryptaphelenchus species are wood- or bark-inhabiting nematodes, generally mycetophagous and reported to have endophoretic associations with insects. In the present study, we describe two new and one known Cryptaphelenchus species detected in imported and domestic wood samples. Cryptaphelenchus americanum n. sp. and C. minutus were detected in the log samples of Pinus taeda imported from the USA, whereas C. orientalis n. sp. was isolated from the bark of dying Pinus sylvestris trees in Inner Mongolia, China. Both new species displayed characteristic features, including a relatively short body length, four lateral lines, a short post-vulval uterine sac in females, and a distinct cloacal apophysis in male tails. Newly recovered and known species were characterised molecularly, and phylogenetic trees were constructed to study their relationship with related Cryptaphelenchus species. Notably, the genetic divergence observed among Cryptaphelenchus species was found to be more significant compared to morphometrical differences, highlighting the importance of molecular data in taxonomy. The identification of new and known species expands our understanding of the genus and suggests that Cryptaphelenchus species may be under studied, underscoring the necessity for continued exploration.
Gender and Theological Tradition
Authors: do Vale Fellipe 
Published: June 2024

Abstract
Two incompatible trends have characterized contemporary systematic theological work. On the one hand, consistency with the broad Christian tradition has grown as a methodological desideratum, especially through the work of theological retrieval. On the other hand, theologians who turn their attention to gender maintain that it cannot look to Christian history for salutary resources. Can a theologian interested in giving an account of gender utilize the recognizable virtues of systematic theology? This article argues that it is possible. By retrieving doctrines that implicate gender, a theologian can be both catholic and sensitive to the right inheritance of the Christian tradition.
“To Seek the Welfare of the City”
Authors: Lowe John T. 
Published: June 2024

Abstract
Andrew Fuller is mostly read in light of his missiological fervor and rarely cast into political light. However, a successive reading of Andrew Fuller on patriotism, benevolence, and slavery will expand our understanding of antislavery narratives and the development of immediatism among religious activity in Europe. Here, Fuller demonstrated how close religion and politics were linked and advocated why piety informed politics well after the English Civil Wars (1642–1651). Moreover, this study illustrates how Calvinistic Baptists both encouraged and resisted civil polity so long as it was informed by biblical interpretation and not the Enlightenment ideals of deistic altruism. While Fuller, and other Calvinistic Baptists, did not possess the same influence as other contemporary Christian abolitionists, such as William Wilberforce (1759–1833), his thoughts on patriotism reveal that the webs of antislavery and abolitionism within the historical and theological veins of the Reformed tradition have yet to be untangled.
Beatific Governance and the Problems of Evil
Authors: Luke Sean 
Published: June 2024

Abstract
Several authors have recently argued that the Reformed doctrine of providence poses particular problems of evil that are intractable. How can one hold to a robust, Reformed doctrine of providence without either making God the author of evil or turning God into a Machiavellian tyrant? In this paper, I outline a model of providence I call “Beatific Governance”, in which God ordains and directs all that comes to pass unto the display of his beauty in all things without being the author of evil; and he does so, I argue, without violating an agent-causal view of freedom. I then resource this model to address several formulations of the problem of evil.
Impact of Vegetation Assimilation on Flash Drought Characteristics across the Continental United States
Authors: Fallah Ali , Barlow Mathew A. , Agel Laurie , Kim Junghoon , Mankin Justin , Mocko David M. , Skinner Christopher B. 
Published: June 2024

Abstract
Predicting and managing the impacts of flash droughts is difficult owing to their rapid onset and intensification. Flash drought monitoring often relies on assessing changes in root-zone soil moisture. However, the lack of widespread soil moisture measurements means that flash drought assessments often use process-based model data like that from the North American Land Data Assimilation System (NLDAS). Such reliance opens flash drought assessment to model biases, particularly from vegetation processes. Here, we examine the influence of vegetation on NLDAS-simulated flash drought characteristics by comparing two experiments covering 1981–2017: open loop (OL), which uses NLDAS surface meteorological forcing to drive a land surface model using prognostic vegetation, and data assimilation (DA), which instead assimilates near-real-time satellite-derived leaf area index (LAI) into the land surface model. The OL simulation consistently underestimates LAI across the United States, causing relatively high soil moisture values. Both experiments produce similar geographic patterns of flash droughts, but OL produces shorter duration events and regional trends in flash drought occurrence that are sometimes opposite to those in DA. Across the Midwest and Southern United States, flash droughts are 4 weeks (about 70%) longer on average in DA than OL. Moreover, across much of the Great Plains, flash drought occurrence has trended upward according to the DA experiment, opposite to the trend in OL. This sensitivity of flash drought to the representation of vegetation suggests that representing plants with greater fidelity could aid in monitoring flash droughts and improve the prediction of flash drought transitions to more persistent and damaging long-term droughts.

Significance Statement
Flash droughts are a subset of droughts with rapid onset and intensification leading to devastating losses to crops. Rapid soil moisture decline is one way to detect flash droughts. Because there is a lack of widespread observational data, we often rely on model outputs of soil moisture. Here, we explore how the representation of vegetation within land surface models influences the U.S. flash drought characteristics covering 1981–2017. We show that the misrepresentation of vegetation status propagates soil moisture biases into flash drought monitoring, impacting our understanding of the onset, magnitude, duration, and trends in flash droughts. Our results suggest that the assimilation of near-real-time vegetation into land surface models could improve the detection, monitoring, and prediction of flash droughts.
Clarifying the Diagnosis and Management of Acute Uncomplicated Pediatric Mastoiditis
Authors: Esce Antoinette R. , Trujillo Samantha A. , Hawley Karen A. 
Published: June 2024

Introduction: Acute pediatric mastoiditis is a bacterial infection of the mastoid bone most commonly associated with acute otitis media. Complicated mastoiditis is traditionally characterized by intracranial complications or subperiosteal abscess, but definitions are inconsistent in the literature. Surgical intervention is identified as the main treatment for complicated mastoiditis, but there is some evidence to support medical management of uncomplicated mastoiditis. This study sought to clarify the diagnostic criteria and management of uncomplicated acute mastoiditis. Methods: All cases of acute pediatric mastoiditis were identified from a single institution over a 16-year period and reviewed for demographic and clinical data. Two different definitions of uncomplicated mastoiditis were compared; the traditional one that excluded patients with intracranial complications or subperiosteal abscess (SPA) and the proposed definition that also excluded patients with any evidence of bony erosion including coalescence, not just SPA. Univariate and multivariate analysis was conducted. Results: Eighty cases were identified. Using the traditional definition of uncomplicated mastoiditis, 46.3% of cases were uncomplicated, compared to 36.2% when using the proposed definition. Truly uncomplicated patients, categorized with the proposed definition, were treated more consistently: no patients underwent mastoidectomy and they were less likely to receive a long term course of antibiotics. On multivariate regression analysis, only categorization with the proposed definition of uncomplicated mastoiditis was independently associated with less long-term antibiotic therapy and non-surgical management. Conclusion: Uncomplicated acute mastoiditis should be defined using clinical criteria and exclude any cases with evidence of bony erosion, including coalescence or subperiosteal abscess. These truly uncomplicated patients often do not require mastoidectomy and can be prescribed a shorter course of antibiotics. Further research into treatment pathways is necessary to optimize the management of uncomplicated acute pediatric mastoiditis.
Subjective evaluation of thermal comfort of tropically acclimatized subjects in air conditioned, naturally ventilated and radiant cooling environments
Authors: Arumugam Jayashree , MP Maiya , SM Shiva Nagendra 
Published: June 2024

The thermal sensation of people is subjective. It depends on the external climatic condition and thermal history of a person. Thermal comfort standards suggest a narrow temperature range to assert an environment as comfortable or otherwise. It is important to evaluate people’s thermal perception in different climatic regions and set comfort limits based on their thermal perception. This study evaluates the thermal perception of subjects in hot and humid climatic regions at higher indoor temperatures and air velocities. Three different thermal environments chosen for the study are air conditioned (AC), naturally ventilated (NV), and radiant cooling (RC) thermal environments. The study shows that more than 80% of subjects voted as comfortable in AC and RC thermal environments for the measured Top and va range of 25.3 – 28.4℃/0.1 – 0.3m/s and 25.9 – 29.1℃/0.1 – 0.9m/s respectively. The findings gathered from the study in NV environment indicate that 68% of subjects opt for the use of table fans over ceiling fans. The subjects' free control of air movement improves their thermal sensation over no control of air movement, indicating that they prefer table fans and free control of air movement. In AC, NV, and RC thermal environments, humidity and air quality remain uncontrolled. In AC and RC thermal environments, less than 20% of subjects voted unacceptable for the humidity sensation and Perceived air quality (PAQ) scales in nearly all the studied experimental conditions. In NV thermal environment, the percentage of subjects voting dissatisfied on the humidity sensation scale and PAQ scale is 30-52% and 26-37%, respectively. This outcome shows that a thermally comfortable environment with air movement improves subjects' humidity sensation and PAQ even when humidity and air quality are unaltered. The study points out that air velocity played a vital role in influencing the thermal sensation, humidity sensation and perceived air quality of subjects in the three studied thermal environments. Further the study shows that with free control of air movement will significantly aid in rising the comfort temperature band of tropically acclimatized subjects. Practical application The study shows the variation in limits of thermal comfort indices such as operative temperature and air velocity for tropically acclimatized subjects in three thermal environments. The same group of subjects participated in the subject study conducted in air conditioned, naturally ventilated and radiant cooling thermal environments. The outcomes indicate that subjects are comfortable at higher indoor temperature and air velocity. Further the outcomes showed that the humidity and air quality sensation of subjects is influenced by the subjects’ thermal sensation and air velocity.
Psychological Interventions for Post-traumatic Stress Disorder as a Primary Diagnosis Among Adolescents: A Meta-analysis
Authors: Arora Silky , Satapathy Sujata 
Published: June 2024

Purpose: The objective of this study was to do a meta-analysis focusing on the efficacy of psychological intervention for the adolescent population and PTSD as a primary outcome variable. Collection and Analysis of Data: An electronic search was conducted on PubMed, Science Direct, PsycINFO, and Cochrane Library databases from January 1, 1990, to March 31, 2023. Original studies and systematic reviews/meta-analyses were segregated. In the first study, 129 meta-analyses (MAs) were screened and 8 MAs were analyzed. In the second study, six RCTs and five non-RCTs exclusively including adolescents with a primary diagnosis of PTSD were analyzed. The MA revealed the average sample size to be 243.33 (SD = 372.94) with 63.98% female participants in RCTs and 153 (SD = 237.17) with 56.99% female participants in non-RCTs. A total of 13 different interventions were analyzed. Cognitive-behavioral intervention had a large effect size of 1.63 for PTSD. Cochrane’s Q test and I2 index revealed considerable heterogeneity among groups. There was no significant difference between RCTs and non-RCTs in the total number and duration of intervention sessions and the duration of each session. However, the average follow-up time points varied significantly between RCTs and non-RCTs. RCTs followed random sequence generation and, hence, had a low risk of selection bias. Conclusion: Although the CBT framework with a focus on trauma and traumatic emotions was at the core of treatment efficacy, the type of trauma was the key consideration. Further studies of treatment efficacy moderated by specific trauma characteristics are required to advance the knowledge base in the treatment of PTSD in adolescents.