bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abiotic Stress Reorganizes Rhizosphere and Endosphere Network Structure of Sorghum bicolor
Authors: Barnes Elle M. , Hartman Kyle , Chiniquy Dawn , Zhao Wenting , Liu Peng , Creech Cody , Schachtman Daniel P. , Tringe Susannah G. 
Published: June 2024

Sorghum bicolor is a promising bioenergy feedstock with high biomass production and unusual tolerance for stresses, such as water and nutrient limitation. Although the membership of the sorghum microbiome in response to stress has been explored, relatively little is known about how microbe–microbe networks change under water- or nutrient-limited conditions. This is important because network changes can indicate impacts on the functionality and stability of microbial communities. We performed network-based analysis on the core bacterial and archaeal community of an agronomically promising high biomass bioenergy genotype, Grassl, grown under nitrogen and water stress. Stress caused relatively minor changes in bacterial abundances within soil, rhizosphere, and endosphere communities but led to significant changes in bacterial network structure and modularity. We found a complete reorganization of network roles in all plant compartments, as well as an increase in the modularity and proportion of positive associations, which potentially could represent coexistence and cooperation in the sorghum bacterial/archaeal community under stress. Although stressors are often believed to be destabilizing, we found stressed networks were as or more stable than non-stressed networks, likely due to their redundancy and compartmentalization. Together, these findings support the idea that both sorghum and its bacterial/archaeal community can be resilient to future environmental stressors. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY 4.0 International license .
Monitoring the Distribution, Incidence, and Symptom Expression Associated with Cotton Leafroll Dwarf Virus in the Southern United States Using a Sentinel Plot System
Authors: Koebernick J. C. , Hagan A. K. , Zaccaron M. , Escalante C. , Jacobson A. L. , Bowen K. L. , Strayer-Scherer A. , Heilsnis B. , Brown S. , Sikora E. J. , Allen T. W. , Faske T. R. , Bourland F. , Greene J. K. , Huseth A. S. , Kelly H. , Kemerait R. C. , Kerns D. , Mulvaney M. , Price P. P. , Small I. , Taylor S. , Wang H. , Conner K. 
Published: June 2024

Cotton leafroll dwarf virus (CLRDV), transmitted by the cotton aphid ( Aphis gossypii Glover), was first confirmed in upland cotton ( Gossypium hirsutum L.) in Alabama, U.S.A., in 2017. Subsequent observations of symptomatic plants followed by virus infection confirmation via reverse transcriptase PCR (RT-PCR) were made in neighboring states in 2018. To assess the distribution and incidence of CLRDV and the occurrence of presumed symptoms across the southern cotton belt, a multidisciplinary team established sentinel plot survey sites at 16 experiment stations in 11 states stretching from Texas to Virginia and Tennessee to Florida beginning in 2019. Field trials were conducted over a 3-year period using multiple cotton cultivars that were adjusted annually. Cotton plots were evaluated at each location by a single evaluator to attempt to correlate symptom occurrence across the cotton-growing region with virus incidence in cotton plant tissues using RT-PCR. Symptom incidence, based on visual estimation of plants in each plot with presumed symptoms, differed across the region and ranged from 0 to 75%, with a low average over all locations of 11.4% in 2021 to an average high of 28.0% in 2020. Though symptom incidence suggested the presence of CLRDV, there were instances where apparent symptoms were observed but virus presence was not confirmed by RT-PCR. CLRDV has since been confirmed from all locations, which suggests that it has become endemic in cotton production areas throughout the eastern range of the United States. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Therapeutic microbiome modulation: new frontiers in HIV treatment
Authors: Bulnes Rene , Utay Netanya S. 
Published: June 2024

Purpose of reviewDysbiosis may be a key driver of systemic inflammation, which increases the risk of non-AIDS events in people living with HIV (PLWH). Modulation of the microbiome to reverse this dysbiosis may be a novel approach to decrease inflammation and therefore morbidity and mortality in PLWH.Recent findingsFecal microbiota transplantation (FMT), probiotics, prebiotics, synbiotics, postbiotics, and dietary modifications have the potential to modulate the microbiome. These interventions have been well tolerated in clinical trials to date. However, these interventions have not resulted in consistent or lasting changes to the microbiome or consistent changes in biomarkers of intestinal permeability, microbial translocation, inflammation, immune activation, or CD4+T cell counts. Sustained engraftment may require prebiotics and/or dietary modifications added to either probiotics or FMT.SummaryAdequately powered randomized controlled trials are needed to elucidate whether microbiome modulation can be achieved and impact systemic inflammation in PLWH.
“Breaking Bread” With Respondents
Authors: Foster Kelly N. , Bright Candace Forbes , Beatty Kate , de Jong Jordan , Surles Kristen , Ventura Liane , Kidd Morgan Jones 
Published: June 2024

Background and Objectives:
To fully understand the impact of unintended pregnancy, as well as to evaluate the implementation and outcomes of programs targeted at reducing unintended pregnancy, it is critical that researchers be able to collect comprehensive data from health clinics that provide these services in vulnerable communities.

Methods:
Our paper details recruitment and incentive strategies, as well as the theories that guided them, which allowed us to achieve a high survey response rate among health clinic administrators in public health clinics in 2 Southeastern states—South Carolina and Alabama—both of which have high rates of unintended pregnancy.

Results:
Grounded in organizational theory, and utilizing the Tailored Design Method, we achieved a 68% response rate utilizing paper and web survey administration with multiple contact modes. Our incentive structure comprised both traditional cash-based and food-based incentives.

Conclusions:
Findings indicate high response rates are achievable despite high survey burden (ie, detailed information, length of survey). We found that sample screening was critical and that food-based incentives made an impression on respondents that positively impacted the researcher–respondent relationship. Providing detailed methodology and additional literature will assist researchers working with similar populations—a gap in the applied methodological literature that was problematic at the project’s onset.
Is YouTube a Sufficient and Reliable Source to Inform Patients About Cardiac Rehabilitation?
Authors: Karataş Levent , Utkan Karasu Ayça , Demirsoy Nesrin 
Published: June 2024

Purpose:
There is a growing concern surrounding the utility of medical content on social media. In this study, the popularity metrics and content quality of cardiac rehabilitation (CR) videos on YouTube regarding patient education were examined.

Methods:
Using the search key word “cardiac rehabilitation,” we analyzed the 50 most relevant videos. Our video popularity analytics encompassed viewing rate, such as ratio, number of comments, and the video power index (VPI). We assessed content quality using the Global Quality Scale (GQS), the modified DISCERN questionnaire, Journal of the American Medical Association (JAMA) benchmark criteria, Patient Education Materials Assessment Tool for Audio/Visual Materials (PEMAT-A/V), and a novel tool, the Cardiac Rehabilitation Specific Scale (CRSS).

Results:
Notably, 78% of the videos were uploaded by medical organizations. The average viewing rate was 4.6 views per day. There were positive correlations between the scores from different content quality scales. Median scores for the GQS, the modified DISCERN questionnaire, JAMA benchmark criteria, and the CRSS were 3, 3.5, 2, and 5, respectively. Mean PEMAT-A/V scores were 60.4% for understandability and 38.3% for actionability. Videos published by entities other than medical centers predicted lower CRSS and GQS scores. High JAMA benchmark criteria scores were negative predictors of VPI, view rate, and number of comments.

Conclusion:
Our findings suggest that CR-related videos on YouTube are characterized by low popularity, average content quality and understandability, but a lack of reliability and actionability. To ensure individuals seek accurate CR information on social media platforms, we recommend directing them to videos uploaded by medical centers.
Left Atrial Peak Systolic Strain as an Indicator Pathway of Diastolic Dysfunction of the Left Ventricle
Authors: Chávez Christian Osmar , Centurión Osmar Antonio , Meza Alfredo Javier , del Pilar Falcón Rocío , Scavenius Karina E. , García Laura B. , Sequeira Orlando R. , Torales Judith M. , Galeano Erdulfo J. 
Published: June 2024

Background:
Left atrial peak systolic strain (LA-PSS) imaging is an emerging index of left atrial function, and it was shown to be decreased in heart failure with preserved ejection fraction (EF). We aimed to determine whether LA-PSS could be used as an additional diagnostic parameter to current existing guidelines for the presence of left ventricle diastolic dysfunction (LVDD).

Materials and Methods:
A total of 190 consecutive adult patients with cardiovascular risk factors and normal left ventricle EF with no prior history of heart failure were included in the study. Speckle tracking software was used to study ventricular parietal deformity, left ventricle global longitudinal systolic strain, and LA-PSS.

Results:
The median left ventricle global longitudinal systolic strain was −19%, with a significant difference (P < 0.001) between patients with normal diastolic function versus those with LVDD. The median LA-PSS was 33% (30% to 38%) (P < 0.001). Most patients (61%) had grade 1 atrial dysfunction based on PSS (range 24%–35%). The analysis of the area under the receiver operating characteristic curve of the LA-PSS as a potential indicator pathway of LVDD was 67% [95% confidence interval (CI), 62–72], and 75% (95% CI, 70–80), when the indeterminate pattern was included. The decreased LA-PSS made it possible to reclassify patients with an indeterminate pattern of diastolic function in 96% of cases.

Conclusions:
These results support the potential role of LA-PSS as an additional parameter for the diagnosis of LVDD in patients with normal EF, and may be integrated into the guidelines for routine evaluation of patients.
The Etiologic Organisms, Risk Factors, and Outcomes of Nosocomial Bloodstream Infections in Pediatric Patients
Authors: Deniz Melis , Şenol Hande , Erat Tugba , Arı Hatice Feray , Altug Ümit , Kıral Eylem 
Published: June 2024

Background
Much of the knowledge regarding pediatric healthcare-associated infections is based on studies conducted in adults. Here, we investigated clinical risk factors and etiologic organisms, focusing on antibiotic and antifungal resistance in pediatric patients with nosocomial bloodstream infections (nBSIs) in pediatric intensive care units (PICUs).

Methods
A retrospective evaluation was conducted on pediatric patients with nBSI in the PICUs of a tertiary referral hospital.

Results
A total of 69 nBSI episodes in 65 patients were observed during the study period. Of these, a total of 40 (57.97%) were caused by Gram-negative bacteria, 6 (8.7%) by Gram-positive bacteria, and 23 (33.33%) by Candida species. The rankings of Gram-negative bacteria were Klebsiella pneumoniae (37.5%), Acinetobacter baumannii (22.5%), and Serratia marcescens (12.5%). Carbapenem resistance was found to be common among K. pneumoniae (40%) and all Acinetobacter species. Most children (54.41%) had spent >28 days in the PICU at the time of diagnosis of nBSI. The presence of central venous catheters was significantly associated with fungal nBSI (P = 0.047).

Conclusions
A high rate of antimicrobial resistance was observed among pathogens. A central venous catheter was associated with fungemia in children hospitalized in PICUs. Prolonged hospital stay before the diagnosis of BSI and the use of medical devices were found to be common in fungal infections.
Genetic factors associated with hidradenitis suppurativa, a literature review
Authors: Eble Shannon M. , Wisco Oliver J. , Boccuto Luigi , Laffin Brian , Parker Veronica G. , Davis Nicole J. , Temples Heide S. 
Published: June 2024

Background:
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by deep-seated, painful lesions most frequently occurring in intertriginous areas of the skin. HS leads to poor quality of life in affected individuals and is difficult to diagnose and treat.

Objective:
Understanding the genetics associated with familial inheritance may lead to a better understanding of the pathogenesis of this debilitating disease.

Methods:
Articles published until March 9, 2023, were identified in PubMed using the following search terms: hidradenitis suppurativa and gene* or acne inversa and gene*.

Results:
The rate of monogenic mutations associated with HS is less than 7%, with the most common genetic mutations reported in sporadic and familial HS cases being in NCSTN and less frequently in PSENEN. Individuals with mutations in the gamma-secretase complex tended to have more severe HS and an early age of onset.

Limitations:
This study was limited to the case studies available in PubMed, the majority of which used targeted gene panels to detect genetic mutations.

Conclusion:
Approximately 30% of individuals diagnosed with HS report having a positive family history; however, very few studies demonstrate monogenic familial transmission of HS. The case studies of syndromic HS reported a variety of genetic mutations associated with HS, some of which were familial, while others were sporadic, suggesting that other pathways may be involved in the pathogenesis of HS and other potential mutations that have yet to be evaluated. More research is needed to understand the genetic mutations in HS.
A network meta-analysis comparative the efficacy of angiotensin-converting enzyme inhibitors and calcium channel blockers in hypertension
Authors: Yao You-Jian , Gui Mei , Cai Shi-Kang 
Published: June 2024

Background:
Currently, most studies primarily focus on directly comparing the efficacy and safety of angiotensin-converting enzyme inhibitors (ACEIs) and calcium channel blockers (CCBs), the two major classes of antihypertensive drugs. Moreover, the majority of studies are based on randomized controlled trials and traditional meta-analyses, with few exploring the efficacy and safety comparisons among various members of ACEIs and CCBs.

Methods:
ACEIs and CCB were searched for in randomized controlled trials in CNKI, Wanfang, VIP, China Biology Medicine Disc (Si-noMed), PubMed, EMbase, and Cochrane Library databases. The search can be conducted till November 2022. Stata software (version 16.0) and R 4.1.3 was used for statistical analysis and graphics plotting, applying mvmeta, gemtc, and its packages. Meta-regression analysis was used to explore the inconsistencies of the studies.

Results:
In 73 trials involving 33 different drugs, a total of 9176 hypertensive patients were included in the analysis, with 4623 in the intervention group and 4553 in the control group. The results of the analysis showed that, according to the SUCRA ranking, felodipine (MD = −12.34, 95% CI: −17.8 to −6.82) was the drug most likely to be the best intervention for systolic blood pressure, while nitrendipine (MD = −8.01, 95% CI: −11.71 to −4.18) was the drug most likely to be the best intervention for diastolic blood pressure. Regarding adverse drug reactions, nifedipine (OR = 0.32, 95% CI: 0.14–0.74) was the drug most likely to be the safest.

Conclusion:
The research findings indicate that nifedipine is the optimal intervention for reducing systolic blood pressure in hypertensive patients, nitrendipine is the optimal intervention for reducing diastolic blood pressure in hypertensive patients, and felodipine is the optimal intervention for safety.
Impact of resistance exercise program on muscle strength, cardiopulmonary function and glycolipid metabolism of bedridden population aged 80 years and above: A randomized controlled trial
Authors: Wang Yingjie , Huo Xiaopeng , Wang Xiaojing , Zhu Hongwei , Lai Xiaoxing , Yu Tong 
Published: June 2024

Background:
This study aimed to evaluate the impact of a resistance exercise program in the bedridden older adults in China.

Methods:
The patients aged 80 years and above with stable diseases were randomly divided into control group (receiving routine treatment and nursing) and training group (receiving the elastic ball and elastic band training applied for 55 minutes, 3 times a week during 6 months).

Results:
A total of 59 patients (control group: 30; training groups: 29) completed the study. In terms of muscle strength, the patients of the training group had better grip strength and supine leg lifts and 30-s sit-to-stand actions. In terms of cardiopulmonary function and glycolipid metabolism, the patients in the training groups had better lung capacity and high-density lipoprotein.

Conclusion:
The low-load and low-intensity resistance training may effectively improve not only the muscle strength of the bedridden older adults, but also the lung function and blood lipid metabolism.
A portent of catastrophic carbon dioxide embolism in laparoscopic hepatectomy: A case report
Authors: Li Mei , Yan Bing , Wang Mi , Zhu Shengmei , Kang Xianhui 
Published: June 2024

Introduction:
Laparoscopic hepatectomy (LH) poses a high risk of carbon dioxide embolism due to extensive hepatic transection, long surgery duration, and dissection of the large hepatic veins or vena cava.

Patient concerns:
A 65-year-old man was scheduled to undergo LH. Following intraperitoneal carbon dioxide (CO2) insufflation and hepatic portal occlusion, the patient developed severe hemodynamic collapse accompanied by a decrease in the pulse oxygen saturation (SpO2).

Diagnosis:
Although a decrease in end-tidal carbon dioxide (ETCO2) was not observed, CO2 embolism was still suspected because of the symptoms.

Interventions and Outcomes:
The patient was successfully resuscitated after the immediate discontinuation of CO2 insufflation and inotrope administration. CO2 embolism must always be suspected during laparoscopic surgery whenever sudden hemodynamic collapse associated with decreased pulse oxygen saturation occurs, regardless of whether ETCO2 changes. Instant arterial blood gas analysis is imperative, and a significant difference between PaCO2 and ETCO2 is indicative of carbon dioxide embolism.

Conclusion:
Instant arterial blood gas analysis is imperative, and a significant difference between PaCO2 and ETCO2 is indicative of carbon dioxide embolism.
Transforming performance: The impact of an 8-week complex training program on strength, power, and change of direction in female basketball athletes
Authors: Wang Bin , Xie Enli , Liang Peigen , Liu Tianshu , Zhu Jian , Qin Guoyang , Su Xin 
Published: June 2024

Background:
This study aimed to investigate the effect of complex training on the strength, power, and change of direction (COD) performance of college female basketball athletes.

Methods:
This design used experimental and randomized studies. A total of 32 female basketball players volunteered to participate in this study and were randomly allocated to a complex training group (CT group: n = 16) and a resistance training group (RT group: n = 16). The CT group performed CT and the RT group completed RT for 8 weeks. The CT and RT programs were developed based on the linear periodization theory, which required participants to train 2 times a week in the first 4 weeks and 3 times a week in the following 4 weeks. All participants were tested using the 5-0-5 COD test, Illinois agility test (IAT), one-repetition maximum back squat (1RM BS) test, and countermovement jump (CMJ) test before and after the 8-week training period.

Results:
Two-way repeated measure ANOVA showed a significant group × time interaction for the 5-0-5 COD, IAT, 1RM BS, and CMJ results after the intervention compared with that before the intervention (P < .05) in the CT group (effect size = 0.86–4.04). CT compared with RT caused remarkably larger enhancements in the IAT (P < .001) and CMJ (P = .040) scores.

Conclusion:
Our findings indicate that the implementation of CT could be a promising and innovative intervention for enhancing the strength, power, and COD performance of female basketball players.
Electroacupuncture for oculomotor nerve palsy after chemotherapy: A case report
Authors: Du Chun , Lu Chao , Li Guangliang , Deng Dehou , Chen Weiji 
Published: June 2024

Introduction:
Oculomotor nerve palsy (ONP) is often discovered in the ophthalmology department, manifested as ptosis with the same side, eyeball in the fixed external booth, or accompanied by limited inward, upward, and downward movements. The present case report described the effect of electroacupuncture (EA) on a breast cancer patient with ONP after chemotherapy.

Patient concerns:
A 56-year-old breast cancer patient presented with severe ptosis and fixed right eye exotropia. Besides, it is challenging to perform the movement inward, upward, and downward, and with obvious diplopia.

Diagnoses:
The breast cancer patient was diagnosed with ONP, chemotherapy history.

Interventions:
The patient was introduced to acupuncture department to receiving EA treatment.

Outcomes:
After 12 times of EA treatments, the symptom of ptosis was significantly improved, and the right upper eyelid can lift autonomously as same as the left eye. Besides, the patient’s right lateral eye could move freely, and the symptoms of double vision disappeared.

Conclusion:
The case suggests that EA may be an effective alternative treatment for ONP.