bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community mental healthcare for people with severe personality disorder: narrative review
Authors: Koekkoek Bauke , van Meijel Berno , Hutschemaekers Giel 
Published: January 2010

Aims and methodTo assess the contents and the theoretical and empirical base of community mental healthcare (CMHC) for people with severe personality disorder. Medline and PsycINFO databases and handbooks were searched from 1980, as well as a recent meta-analysis and systematic review of trials in which CMHC served as the control condition.ResultsCommunity mental healthcare is a long-term community-based treatment within a supportive atmosphere, aimed at stability rather than change. Mostly offered by community psychiatric nurses, occupational therapists and social workers, it lacks a formal structure, as well as theoretical underpinnings that guide interventions.Clinical implicationsCommunity mental healthcare might profit from a more systematic application of effective ingredients from other treatments.
TP53 Mutations and Pathologic Complete Response to Neoadjuvant Cisplatin and Fluorouracil Chemotherapy in Resected Oral Cavity Squamous Cell Carcinoma
Authors: Perrone Federica , Bossi Paolo , Cortelazzi Barbara , Locati Laura , Quattrone Pasquale , Pierotti Marco A. , Pilotti Silvana , Licitra Lisa 
Published: January 2010

Purpose To find out if TP53 functional status predicts response to neoadjuvant chemotherapy and thus may be helpful during treatment decision making of oral cavity squamous cell carcinoma (SCC) patients. Patients and Methods We analyzed the predictive value of TP53 mutations and their functional status on the basis of the transactivation activity of p53 mutant proteins in 53 pretreatment biopsies of oral cavity SCC patients receiving primary cisplatin and fluorouracil chemotherapy followed by surgery. Results The surgical specimens showed that 15 patients (28%) achieved a pathologic complete remission (pCR) at both T and N sites, and 38 patients had residual tumor cells. Among the 53 pretreatment biopsies, 24 (45%) displayed TP53 mutations: 22 single-nucleotide substitutions and two deletions. According to functional status that could be determined only for the 22 substitutions, 21 mutations were nonfunctional and one was partially functional. TP53 mutation was found in four (27%) of 15 patients who achieved a pCR and in 20 (53%) of 38 nonresponder patients; the difference was not statistically significant (P = .12). In contrast, two (14%) of 14 cases with pCR carried a nonfunctional TP53 mutation, a frequency significantly less than that found in the nonresponders (19 [51%] of 37; P = .02). TP53 mutation predicted pCR in four (17%) of 24 patients and a nonfunctional mutation in only two (9%) of 22 patients. Conclusion The results indicate that the loss of function (transactivation activities) of p53 mutant proteins may predict a significant low pCR rate and suboptimal response to cisplatin-based neoadjuvant chemotherapy in patients with oral cavity SCC.
Validation of a Web-Based Predictive Nomogram for Ipsilateral Breast Tumor Recurrence After Breast Conserving Therapy
Authors: Sanghani Mona , Truong Pauline T. , Raad Rita Abi , Niemierko Andrzej , Lesperance Mary , Olivotto Ivo A. , Wazer David E. , Taghian Alphonse G. 
Published: January 2010

PurposeIBTR! version 1.0 is a web-based tool that uses literature-derived relative risk ratios for seven clinicopathologic variables to predict ipsilateral breast tumor recurrence (IBTR) after breast-conserving therapy (BCT). Preliminary testing demonstrated over-estimation in high-risk subgroups. This study uses two independent population-based datasets to create and validate a modified nomogram, IBTR! version 2.0.MethodsCox regression modeling was performed on 7,811 patients treated with BCT at the British Columbia Cancer Agency (median follow-up, 9.4 years). Population-based hazard ratios were generated for the seven variables in the original nomogram. A modified nomogram was then tested against 664 patients from Massachusetts General Hospital (median follow-up, 9.3 years). The mean predicted and observed 10-year estimates were compared for the entire cohort and for four groups predefined by nomogram-predicted risks: group 1: less than 3%; group 2: 3% to 5%; group 3: 5% to 10%; and group 4: more than 10%.ResultsIBTR! version 2.0 predicted an overall 10-year IBTR estimate of 4.0% (95% CI, 3.8 to 4.2), while the observed estimate was 2.8% (95% CI, 1.6 to 4.7; P = .10). The predicted and observed IBTR estimates were: group 1 (n = 283): 2.2% versus 1.3%, P = .40; group 2 (n = 237): 3.8% versus 3.5%, P = .80; group 3 (n = 111): 6.7% versus 3.2%, P = .05; and group 4 (n = 33): 12.5% versus 8.7%, P = .50.ConclusionIBTR! version 2.0 is accurate in the majority of patients with a low to moderate risk of in-breast recurrence. The nomogram still overestimates risk in a minority of patients with higher risk features. Validation in a larger prospective data set is warranted.
Exercise, Tea Consumption, and Depression Among Breast Cancer Survivors
Authors: Chen Xiaoli , Lu Wei , Zheng Ying , Gu Kai , Chen Zhi , Zheng Wei , Shu Xiao Ou 
Published: January 2010

Purpose To examine the association of lifestyle factors and supplement use with depression among breast cancer survivors. Patients and Methods In a population-based cohort study conducted between April 2002 and December 2006 in Shanghai, China, a total of 1,399 women who were diagnosed with stage 0 to III breast cancer completed 6-month and 18-month postdiagnosis, in-person interviews. Information on sociodemographic, clinical, and lifestyle factors were collected through the interviews and through review of medical charts at approximately 6 months postdiagnosis. A metabolic equivalent (MET) score was calculated from reported exercise activities. Quality of life (QOL) was evaluated by the Medical Outcomes Short Form-36 Health Survey at 6 months postdiagnosis. Depressive symptoms were measured by using a 20-item Center for Epidemiological Studies–Depression Scale at approximately 18 months postdiagnosis. Results Overall, 26% of women reported depressive symptoms and 13% met the criteria of clinical depression at 18 months postdiagnosis. Women with a higher exercise level (ie, ≥ 8.3 MET h/wk) were less likely to have depression than nonexercisers; the multivariate adjusted odds ratios (ORs) were 0.71 (95% CI, 0.47 to 1.07) for mild depression and 0.56 (95% CI, 0.35 to 0.88) for clinical depression in analyses controlled for sociodemographic and clinical factors and baseline QOL. Women who increased their exercise level had lower risk for depression. Regular tea consumption (ie, > 100 g dried tea leaves/mo) was inversely associated with overall depression (OR, 0.39; 95% CI, 0.19 to 0.84). No associations were found for dietary intake or supplement use with depression. Conclusion Regular exercise participation and tea consumption may play an important role in the prevention of depression among breast cancer survivors.
Efficacy of Low-Dose Interferon α2a 18 Versus 60 Months of Treatment in Patients With Primary Melanoma of ≥ 1.5 mm Tumor Thickness: Results of a Randomized Phase III DeCOG Trial
Authors: Hauschild Axel , Weichenthal Michael , Rass Knuth , Linse Ruthild , Berking Carola , Böttjer Jörg , Vogt Thomas , Spieth Konstanze , Eigentler Thomas , Brockmeyer Norbert H. , Stein Annette , Näher Helmut , Schadendorf Dirk , Mohr Peter , Kaatz Martin , Tronnier Michael , Hein Rüdiger , Schuler Gerold , Egberts Friederike , Garbe Claus 
Published: January 2010

Purpose Low-dose (LD) interferon (IFN) alfa (LDI) has demonstrated a consistent disease-free survival benefit for patients with clinically lymph node–negative melanoma in clinical trials. However, the optimal duration of treatment is still under discussion, and no previous trial has evaluated this question specifically. A prolongation of LDI from 18 months to 60 months might be of clinical benefit for patients with intermediate or high-risk melanoma. Patients and Methods Eight hundred fifty patients with resected cutaneous melanoma of at least 1.5 mm tumor thickness were included in this prospective randomized, multicenter trial in Germany and Austria. Patients had to be clinically lymph node–negative, and sentinel node biopsy (SLNB) was performed in a majority of cases. They were randomly assigned to receive 3 MU IFNα2a three times a week subcutaneously for either 18 months (arm A) or 60 months (arm B). Results Of 850 randomly assigned patients, 840 were eligible for evaluation after a median follow-up of 4.3 years. Tumor thickness and other relevant prognostic factors were well balanced between both groups. SLNB was performed in 635 patients (75.6%), with a positivity rate of 18.0% in arm A and 17.5% in arm B. Neither relapse-free survival (arm A, 75.6% v arm B, 72.6%; P = .72; hazard ratio, 1.05; 95% CI, 0.80 to 1.39) nor distant-metastasis–free survival (81.9% v 79.7%; P = .56; HR, 1.10; 95% CI, 0.80 to 1.52) or overall survival (85.9% v 84.9%; P = .86; HR, 1.03; 95% CI, 0.71 to 1.50) showed significant differences. Conclusion A prolongation of conventional LDI therapy from 18 to 60 months showed no clinical benefit in patients with intermediate and high-risk primary melanoma.
Randomized Study of Intensified Anthracycline Doses for Induction and Recombinant Interleukin-2 for Maintenance in Patients With Acute Myeloid Leukemia Age 50 to 70 Years: Results of the ALFA-9801 Study
Authors: Pautas Cecile , Merabet Fatiha , Thomas Xavier , Raffoux Emmanuel , Gardin Claude , Corm Selim , Bourhis Jean-Henri , Reman Oumedaly , Turlure Pascal , Contentin Nathalie , de Revel Thierry , Rousselot Philippe , Preudhomme Claude , Bordessoule Dominique , Fenaux Pierre , Terré Christine , Michallet Mauricette , Dombret Hervé , Chevret Sylvie , Castaigne Sylvie 
Published: January 2010

PurposeIn patients with acute myeloid leukemia (AML), induction chemotherapy is based on standard doses of anthracyclines and cytarabine. High doses of cytarabine have been reported as being too toxic for patients older than age 50 years, but few studies have evaluated intensified doses of anthracyclines.Patients and MethodsIn this randomized Acute Leukemia French Association 9801 (ALFA-9801) study, high doses of daunorubicin (DNR; 80 mg/m2/d × 3 days) or idarubicin (IDA4; 12 mg/m2/d × 4 days) were compared with standard doses of idarubicin (IDA3; 12 mg/m2/d × 3 days) for remission induction in patients age 50 to 70 years, with an event-free survival (EFS) end point. After two consolidation courses based on intermediate doses of cytarabine, patients in continuous remission were randomly assigned to receive or not receive maintenance therapy with recombinant interleukin-2 (rIL-2; 5 × 106U/m2× 5 days each month) for a total duration of 12 months. A total of 468 patients entered the study (median age, 60 years).ResultsOverall complete remission rate was 77% with significant differences among the three randomization arms (83%, 78%, and 70% in the IDA3, IDA4, and DNR arms, respectively; P = .04). However, no significant differences were observed in relapse incidence, EFS, or overall survival among the three arms. In the 161 patients randomly assigned for maintenance therapy, no difference in outcome was observed between the rIL-2 and the no further treatment arms.ConclusionNeither intensification of anthracycline doses nor maintenance with rIL-2 showed a significant impact on AML course, at least as scheduled in this trial.
Alternating Systemic and Hepatic Artery Infusion Therapy for Resected Liver Metastases From Colorectal Cancer: A North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) Phase II Intergroup Trial, N9945/CI-66
Authors: Alberts Steven R. , Roh Mark S. , Mahoney Michelle R. , O'Connell Michael J. , Nagorney David M. , Wagman Lawrence , Smyrk Thomas C. , Weiland Timothy L. , Lai Lily Lau , Schwarz Roderich E. , Molina Roy , Dentchev Todor , Bolton John S. 
Published: January 2010

Purpose Prior trials have shown that surgery followed by hepatic artery infusion (HAI) of floxuridine (FUDR) alternating with systemic fluorouracil improves survival rates. Oxaliplatin combined with capecitabine has demonstrated activity in advanced colorectal cancer. Based on this observation a trial was conducted to assess the potential benefit of systemic oxaliplatin and capecitabine alternating with HAI of FUDR. The primary end point was 2-year survival. Patients and Methods Patients with liver-only metastases from colorectal cancer amenable to resection or cryoablation were eligible. HAI and systemic therapy was initiated after metastasectomy. Alternating courses of HAI consisted of 0.2 mg/m2/d FUDR and dexamethasone, day 1 through 14 weeks 1 and 2. Systemic therapy included oxaliplatin 130 mg/m2 day 1 with capecitabine at 1,000 mg/m2 twice daily, days 1 through 14, weeks 4 and 5. Two additional 3-week courses of systemic therapy were given. Capecitabine was reduced to 850 mg/m2 twice daily after interim review of toxicity. Results Fifty-five of 76 eligible patients were able to initiate protocol-directed therapy and completed median of six cycles (range, one to six). Three postoperative or treatment-related deaths were reported. Overall, 88% of evaluable patients were alive at 2 years. With a median follow-up of 4.8 years, a total of 30 patients have had disease recurrence, 11 involving the liver. Median disease-free survival was 32.7 months. Conclusion Alternating HAI of FUDR and systemic capecitabine and oxaliplatin met the prespecified end point of higher than 85% survival at 2 years and was clinically tolerable. However, the merits of this approach need to be established with a phase III trial.
Latino Disparities in Prescription Drug Use and Expenditures: A Nationally Representative Analysis
Authors: Chen Jie , Fang Hai , Vargas-Bustamante Arturo , Rizzo John A , Ortega Alexander N 
Published: January 2010

BACKGROUND Latinos are disproportionately affected by the lack of affordable prescription drugs. Within the Latino population, there are significant heterogeneities in the patterns of prescription drug expenditures and use. However, studies have traditionally treated them as a single, monolithic group. OBJECTIVES gTo identify and quantify factors associated with disparities in drug use and expenditures between non-Latino whites and Latino subgroups. METHODS We examined trends in prescription drug use, total prescription drug expenditures, and the proportion of out-of-pocket (OOP) payment to total drug expenditures for whites and Latino subgroups using the Medical Expenditure Panel Survey from 1999 to 2006. Multivariate regressions were used to adjust for confounding factors that may also affect drug use and expenditures. RESULTS Latinos were significantly less likely to use drugs compared to whites. Mexicans had significantly lower prescription drug costs and a higher proportion of OOP expenditures compared to whites after socioeconomic and demographic factors were controlled. Usual source of care, health insurance, and limited English proficiency were the most important factors associated with these disparities. Among the Latino subgroups, Puerto Ricans had drug expenditures and use patterns most similar to those of whites. CONCLUSIONS Substantive disparities in prescription drug expenditures and use existed between whites and specific Latinos groups, with Mexicans faring the worst. Future health studies should examine Latino subgroups separately, rather than treating Latinos as a homogeneous group. Policies aimed at expanding insurance coverage and access to a usual source of care, as well as addressing language barriers, should substantially reduce these disparities.
Use of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to Investigate Group and Gender Differences in Schizophrenia and Bipolar Disorder
Authors: Gogos Andrea , Joshua Nicole , Rossell Susan L. 
Published: January 2010

Objective: Gender differences exist in schizophrenia and bipolar disorder (BD), therefore the aim of the present study was to clarify the role of gender in cognitive deficits in these disorders. Methods: Cognitive performance was examined in schizophrenia (24M: 14F) and BD (16M: 24F) patients compared with age-, IQ- and gender-matched control participants (21M: 22F). The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was used to assess five cognitive domains: immediate memory/learning, visuospatial ability, language, attention, and delayed memory, which are summed to provide a Total score. Results: In comparison to controls, schizophrenia patients showed deficits on all domains, while BD patients had impaired immediate memory/learning, language and Total score. Schizophrenia patients showed deficits compared to BD in the Total score, immediate and delayed memory and visuospatial ability. The Total and domain scores were not different in men and women across or within groups. There were gender effects on four of the 12 individual cognitive tasks, in which female patients outperformed male patients. Further, there were gender differences across groups for three of the individual tasks: female schizophrenia patients showed poorer story memory and story recall compared to male schizophrenia patients; female BD patients had enhanced figure copy performance compared to male BD patients. Conclusions: The RBANS highlighted the cognitive deficits in schizophrenia and BD patients compared to controls and also each other. There were no overall gender differences in cognition.
A Brief Measure of Vocational Activity and Community Participation: Development and Reliability of the Activity and Participation Questionnaire
Authors: Stewart Gavin , Sara Grant , Harris Meredith , Waghorn Geoffrey , Hall Anna , Sivarajasingam Siva , Gladman Beverley , Mowry Bryan 
Published: January 2010

Objectives: Social and economic marginalization are significant problems for many people living with mental illness. Clinicians and policy-makers have increased their focus on these aspects of recovery. Current outcome measures, however, do not support this focus, and detailed functional measures are not suitable for routine clinical use. This report describes the development and test–retest reliability of the Activity and Participation Questionnaire (APQ6); a self-report measure of vocational activity and social participation for routine use in community mental health services. Method: The APQ6 was developed from concepts of the Australian Bureau of Statistics Labour Force Surveys and Census. Field testing and consumer consultation were undertaken in New South Wales (NSW) mental health rehabilitation services. Test–retest reliability trials were conducted simultaneously by research teams in NSW and Queensland. Results: Pairs of short-cycle test–retest reliability interviews were obtained from 129 mental health service consumers. Consumer feedback and test–retest reliability results at question and item levels indicate good construct validity. The measure has utility as both a telephone and a personal interview in community mental health settings. Conclusions: The reported psychometric properties support the proposed use of the APQ6 as a recovery-orientated measure focusing on vocational activity and community participation. The APQ6 is being introduced for routine use by NSW mental health services.
Increased Risk of Acute Myocardial Infarction After Acute Episode of Schizophrenia: 6 Year Follow-Up Study
Authors: Lin Hung-Chuan , Chen Yi-Hua , Lee Hsin-Chien , Lin Herng-Ching 
Published: January 2010

Objective: The aim of the present study was to estimate the risk of acute myocardial infarction (AMI) among patients who received a first hospital diagnosis of schizophrenia during a 6 year follow-up period. Method: Data from the Taiwan National Health Insurance Research Database were used. The study cohort consisted of 7353 patients who were hospitalized with a principal diagnosis of schizophrenia in 2000. The comparison cohort were 22 059 enrollees randomly selected matched with the study group in terms of gender and age. Each patient was tracked from their index hospitalization in 2000 until the end of 2006 to identify whether or not an AMI had occurred during the follow-up period. Cox proportional hazard regressions were performed to compute the adjusted 6 year survival rate, following adjustment for possible confounding variables. Results: A total of 130 patients suffered AMI during the 6 year follow-up period, including 30 from the study cohort (0.41% of the schizophrenia patients), and 100 (0.45%) from the comparison cohort. But after censoring those patients who died from non-AMI causes and adjusting for potential confounding factors, the risk of AMI occurrence during the 6 year follow-up period was 1.83-fold greater for schizophrenia patients (95% confidence interval 5 1.62–2.05) than for patients in the comparison cohort. Conclusion: Schizophrenia patients had a higher risk of AMI compared to patients in the comparison cohort. The present study draws attention to the need for clinicians to more actively monitor and treat schizophrenia patients with well-recognized risk factors associated with AMI.
Characteristics of Chinese Service Users in an Old Age Psychiatry Service in New Zealand
Authors: Cheung Gary 
Published: January 2010

Objective: There is a paucity of research on the mental health issues of older Chinese people in New Zealand. This study aimed to describe the profiles of Chinese service users in a community-based old age psychiatry service. Method: There were 22 older Chinese service users at the time of this cross-sectional analysis. Information on their demographics, referral pattern, diagnosis and treatment was obtained from their medical records and compared with a sample of 22 non-Chinese service users. Results: The referral rates for Chinese and non-Chinese were 0.8% and 1.2% respectively. There did not appear to be any differences in the gender ratio, mean age, referral sources, diagnosis and medication use in the Chinese and non-Chinese groups. The largest observed differences were the higher rates of physical aggression at referral, use of Mental Health Act and inpatient treatment in the Chinese group. These observations suggest there might have been a delay in seeking care until psychiatric symptoms became unmanageable. Conclusions: There is a need for further research to improve primary care, mental health service access and responsiveness for older Chinese and other Asian minority groups.
Quinoxalines as Orchard Acaricides in British Columbia
Authors: Downing R. S. 
Published: January 2010

AbstractThe quinoxalines, Eradex and Morestan, were found to be very effective miticides in laboratory and orchard experiments with the latter the most toxic. Applied at the pink stage of apple bud development Eradex and Morestan gave excellent control of European red mite, Panonychus ulmi (Koch), and delayed the build-up of the apple rust mite, Vasates schlechtendali (Nal.), and the McDaniel spider mite, Tetranychus mcdanieli McG. Both miticides were also very effective when applied in summer. The rates of use for Morestan were established at 8 to 16 ounces of active ingredient per acre in concentrate sprayers and at 2 ounces per 100 gallons in handgun sprayers and at twice these rates for Eradex. Where Eradex or Morestan were the only miticides used in an orchard for four years, the control of the European red mite and the McDaniel spider mite was excellent, an indication that selection of a resistant strain had not occurred. Morestan was highly toxic to the predaceous phytoseiid mite, Neoseiulus caudiglans (Schuster). Morestan has not injured fruit or foliage when applied at the pink bud stage but has marked fruit when applied in summer especially when applied by high-volume handgun sprayer.
The Genera of the Ammophilini (Hymenoptera: Sphecidae)
Authors: Menke A. S. 
Published: January 2010

AbstractSix genera are recognized in the tribe Ammophilini: Ammophila, Podalonia, Eremnophila, Eremochares, Hoplammophila and Parapsammophila. A synonymical species checklist is given for the last three genera. A key to genera is provided which is based partially on characters heretofore unutilized.