bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunoglobulin G4-related disease presenting with nephrotic syndrome due to minimal change disease: a case report
Authors: Needleman Amy , Sheaff Michael , Pepper Ruth J. , Evans Rhys D. R. 
Published: April 2024

Abstract
Background
Immunoglobulin G4-related disease is an inflammatory disease affecting multiple organs including the kidney. Immunoglobulin G4-related kidney disease most commonly manifests as a tubulointerstitial nephritis and is associated with glomerular disease in a proportion of cases. Membranous nephropathy is the most frequent glomerular lesion. Herein, we report the first documented case of immunoglobulin G4-related disease presenting with nephrotic syndrome owing to minimal change disease.

Case presentation
A 67-year-old South Asian male presented to our service with systemic upset and leg swelling. He had heavy proteinuria (urine protein:creatinine ratio 1042 mg/mmol) and was hypoalbuminemic (17 g/L) and hypercholersterolemic (9.3 mmol/L), consistent with the nephrotic syndrome. His serum creatinine was 140 μmol/L, and he was hypocomplementemic (C3 0.59 g/L, C4 < 0.02 g/L) with raised immunoglobulin G4 subclass levels (5.29 g/L). Kidney biopsy demonstrated minimal change disease alongside a plasma-cell-rich tubulointerstitial nephritis with strong positive staining for immunoglobulin G4. A diagnosis of minimal change disease in the setting of immunoglobulin G4-related disease was made. He was commenced on oral prednisolone at 60 mg daily but suffered infectious complications, including necrotizing fasciitis within 3 weeks of starting treatment, ultimately resulting in his death 52 days after initial presentation.

Conclusion
This case highlights the potential for immunoglobulin G4-related disease to be associated with a spectrum of glomerular pathologies including minimal change disease. It adds to the differential diagnosis of secondary causes of minimal change disease, and moreover, aids as an important reminder of the potential complications of high-dose steroids used in its treatment.
Dimorphic effect of TFE3 in determining mitochondrial and lysosomal content in muscle following denervation
Authors: Oliveira Ashley N. , Memme Jonathan M. , Wong Jenna , Hood David A. 
Published: April 2024

AbstractBackgroundMuscle atrophy is a common consequence of the loss of innervation and is accompanied by mitochondrial dysfunction. Mitophagy is the adaptive process through which damaged mitochondria are removed via the lysosomes, which are regulated in part by the transcription factor TFE3. The role of lysosomes and TFE3 are poorly understood in muscle atrophy, and the effect of biological sex is widely underreported.MethodsWild-type (WT) mice, along with mice lacking TFE3 (KO), a transcriptional regulator of lysosomal and autophagy-related genes, were subjected to unilateral sciatic nerve denervation for up to 7 days, while the contralateral limb was sham-operated and served as an internal control. A subset of animals was treated with colchicine to capture mitophagy flux.ResultsWT females exhibited elevated oxygen consumption rates during active respiratory states compared to males, however this was blunted in the absence of TFE3. Females exhibited higher mitophagy flux rates and greater lysosomal content basally compared to males that was independent of TFE3 expression. Following denervation, female mice exhibited less muscle atrophy compared to male counterparts. Intriguingly, this sex-dependent muscle sparing was lost in the absence of TFE3. Denervation resulted in 45% and 27% losses of mitochondrial content in WT and KO males respectively, however females were completely protected against this decline. Decreases in mitochondrial function were more severe in WT females compared to males following denervation, as ROS emission was 2.4-fold higher. In response to denervation, LC3-II mitophagy flux was reduced by 44% in females, likely contributing to the maintenance of mitochondrial content and elevated ROS emission, however this response was dysregulated in the absence of TFE3. While both males and females exhibited increased lysosomal content following denervation, this response was augmented in females in a TFE3-dependent manner.ConclusionsFemales have higher lysosomal content and mitophagy flux basally compared to males, likely contributing to the improved mitochondrial phenotype. Denervation-induced mitochondrial adaptations were sexually dimorphic, as females preferentially preserve content at the expense of function, while males display a tendency to maintain mitochondrial function. Our data illustrate that TFE3 is vital for the sex-dependent differences in mitochondrial function, and in determining the denervation-induced atrophy phenotype.
PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief
Authors: Deng Daling , Zhang Tianhao , Ma Lulin , Zhao Wenjing , Huang Shiqian , Wang Kaixing , Shu Shaofang , Chen Xiangdong 
Published: April 2024

AbstractPain is a common symptom of many diseases with a high incidence rate. Clinically, drug treatment, as the main method to relieve pain at present, is often accompanied by different degrees of adverse reactions. Therefore, it is urgent to gain a profound understanding of the pain mechanisms in order to develop advantageous analgesic targets. The PD-L1/PD-1 pathway, an important inhibitory molecule in the immune system, has taken part in regulating neuroinflammation and immune response. Accumulating evidence indicates that the PD-L1/PD-1 pathway is aberrantly activated in various pain models. And blocking PD-L1/PD-1 pathway will aggravate pain behaviors. This review aims to summarize the emerging evidence on the role of the PD-L1/PD-1 pathway in alleviating pain and provide an overview of the mechanisms involved in pain resolution, including the regulation of macrophages, microglia, T cells, as well as nociceptor neurons. However, its underlying mechanism still needs to be further elucidated in the future. In conclusion, despite more deep researches are needed, these pioneering studies indicate that PD-L1/PD-1 may be a potential neuroimmune target for pain relief.
Microbiological features of drowning-associated pneumonia: a systematic review and meta-analysis
Authors: Cousin Vladimir L. , Pittet Laure F. 
Published: April 2024

Abstract
Background
Drowning-associated pneumonia (DAP) is frequent in drowned patients, and possibly increases mortality. A better understanding of the microorganisms causing DAP could improve the adequacy of empirical antimicrobial therapy. We aimed to describe the pooled prevalence of DAP, the microorganisms involved, and the impact of DAP on drowned patients.

Methods
Systematic review and meta-analysis of studies published between 01/2000 and 07/2023 reporting on DAP occurrence and microorganisms involved.

Results
Of 309 unique articles screened, 6 were included, involving 688 patients. All were retrospective cohort studies, with a number of patients ranging from 37 to 270. Studies were conducted in Europe (France N = 3 and Netherland N = 1), United States of America (N = 1) and French West Indies (N = 1). Mortality ranged between 18 to 81%. The pooled prevalence of DAP was 39% (95%CI 29–48), similarly following freshwater (pooled prevalence 44%, 95%CI 36–52) or seawater drowning (pooled prevalence 42%, 95%CI 32–53). DAP did not significantly impact mortality (pooled odds ratio 1.43, 95%CI 0.56–3.67) but this estimation was based on two studies only. Respiratory samplings isolated 171 microorganisms, mostly Gram negative (98/171, 57%) and mainly Aeromonas sp. (20/171, 12%). Gram positive microorganisms represented 38/171 (22%) isolates, mainly Staphylococcus aureus (21/171, 12%). Water salinity levels had a limited impact on the distribution of microorganisms, except for Aeromonas sp. who were exclusively found following freshwater drowning (19/106, 18%) and never following seawater drowning (0%) (p = 0.001). No studies reported multidrug-resistant organisms but nearly 30% of the isolated microorganisms were resistant to amoxicillin-clavulanate, the drug that was the most commonly prescribed empirically for DAP.

Conclusions
DAP are commonly caused by Gram-negative bacteria, especially Aeromonas sp. which is exclusively isolated following freshwater drowning. Empirical antimicrobial therapy should consider covering them, noting than amoxicillin-clavulanate may be inadequate in about one-third of the cases. The impact of DAP on patients’ outcome is still unclear.
Reliable urban vehicle localization under faulty satellite navigation signals
Authors: Gupta Shubh , Gao Grace X. 
Published: April 2024

AbstractReliable urban navigation using global navigation satellite system requires accurately estimating vehicle position despite measurement faults and monitoring the trustworthiness (or integrity) of the estimated location. However, reflected signals in urban areas introduce biases (or faults) in multiple measurements, while blocked signals reduce the number of available measurements, hindering robust localization and integrity monitoring. This paper presents a novel particle filter framework to address these challenges. First, a Bayesian fault-robust optimization task, formulated through a Gaussian mixture model (GMM) measurement likelihood, is integrated into the particle filter to mitigate faults in multiple measurement for enhanced positioning accuracy. Building on this, a novel test statistic leveraging the particle filter distribution and the GMM likelihood is devised to monitor the integrity of the localization by detecting errors exceeding a safe threshold. The performance of the proposed framework is demonstrated on real-world and simulated urban driving data. Our localization algorithm consistently achieves smaller positioning errors compared to existing filters under multiple faults. Furthermore, the proposed integrity monitor exhibits fewer missed and false alarms in detecting unsafe large localization errors.
Internet-delivered therapy for alcohol misuse: engagement, satisfaction, and outcomes when patients select their preference for therapist- or self-guided treatment
Authors: Sapkota Ram P. , Lozinski Tristen , Wilhems Andrew , Nugent Marcie , Schaub Michael P. , Keough Matthew T. , Sundström Christopher , Hadjistavropoulos Heather D. 
Published: April 2024

Abstract
Background
Alcohol misuse is common and causes substantial harm. Internet-delivered cognitive behaviour therapy (ICBT) is effective in reducing alcohol misuse; however, the literature investigating how treatment outcomes are impacted by patients’ preferences for therapist- versus self-guided ICBT for alcohol misuse is sparse.

Methods
In this preference trial, 74 eligible patients (who reported ≥ 14 drinks in the previous week and obtained scores suggesting hazardous or harmful drinking) chose between enrolling in either therapist- or self-guided ICBT for alcohol misuse. We investigated whether those who chose therapist- versus self-guided ICBT differed in their (a) drinking outcomes—as measured by Timeline Follow-Back (TLFB) and heavy drinking days (HDD) at post-treatment and 3-month follow-up—and (b) post-treatment ICBT engagement and satisfaction.

Results
The majority (81.1%) of eligible patients chose therapist-guided ICBT. These patients reported higher psychotropic medication use, drinking difficulties, and anxiety symptoms. For both the therapist- and self-guided patients, a modified intention-to-treat analysis revealed large within-group treatment effects for TLFB (β =  − 2.64, SE 0.66; p < 0.001) and HDD (β =  − 0.34, SE 0.07; p < 0.001), with large pre-to-post-treatment Cohen’s effect sizes of d = 0.97 (95% CI [0.49, 1.45]) for TLFB and d = 1.19 (95% CI [0.69, 1.68]) for HDD. The interaction comparing the effects of therapist- to self-guided ICBT over time was not significant for TLFB (p = 0.34) or HDD (p = 0.06). With treatment, for both therapist- and self-guided patients, there was a significant improvement in drinking difficulties, cravings, and confidence with controlling cravings, as well as in anxiety, depression, and functional impairment. Further, the majority (75.7%) of patients completed five or more lessons, as well as reported overall satisfaction with the treatment (88.9%) and increased confidence in managing their symptoms (86.7%); these outcomes also did not differ between therapist- and self-guided patients.

Conclusions
The current study shows that ICBT for alcohol misuse is associated with reduced drinking and comorbid mental health difficulties over time, irrespective of whether patients chose to complete the course on their own or with therapist guidance.
Trial registration number: NCT04611854 (https://clinicaltrials.gov/ct2/show/NCT04611854).
Hyperoside ameliorates depression-like behavior in ovariectomized mice
Authors: Hong Kyung Hee , Jung Jonghoon , Kim Minji , Um Min Young 
Published: April 2024

AbstractThe physiological changes caused by the decline in estrogen levels due to menopause are linked to an increased risk of depression. This study investigated the antidepressant effects of hyperoside (HYP), a natural flavonol glycoside, and its associated molecular mechanisms in primary hippocampal neurons and ovariectomized (OVX) mice. HYP treatment increased nitric oxide (NO) production and neuronal nitric oxide synthase (nNOS) expression in primary hippocampal neurons; additionally, it upregulated the expression of brain-derived neurotrophic factor (BDNF) and phosphorylated tropomyosin receptor kinase B (TrkB). In OVX mice, HYP treatment significantly improved depression-like behaviors in an open field test to a level comparable to estrogen treatment. Furthermore, HYP treatment upregulated OVX-induced decreased nNOS expression and BDNF-TrkB signaling in the hippocampus. Therefore, this study suggests that HYP exhibits antidepressant potential by addressing estrogen deficiency-induced alterations, specifically by restoring nNOS expression, promoting NO production, and concurrently enhancing BDNF-TrkB signaling in OVX mice.
What does it mean to be good at peer reviewing? A multidimensional scaling and cluster analysis study of behavioral indicators of peer feedback literacy
Authors: Zhang Yi , Schunn Christian D. , Wu Yong 
Published: April 2024

AbstractPeer feedback literacy is becoming increasingly important in higher education as peer feedback has substantially grown as a pedagogical approach. However, quality of produced feedback, a key behavioral aspect of peer feedback literacy, lacks a systematic and evidence-based conceptualization to guide research, instruction, and system design. We introduce a novel framework involving six conceptual dimensions of peer feedback quality that can be measured and supported in online peer feedback contexts: reviewing process, rating accuracy, feedback amount, perceived comment quality, actual comment quality, and feedback content. We then test the underlying dimensionality of student competencies through correlational analysis, Multidimensional Scaling, and cluster analysis, using data from 844 students engaged in online peer feedback in a university-level course. The separability of the conceptual dimensions is largely supported in the cluster analysis. However, the cluster analysis also suggests restructuring perceived and actual comment quality in terms of initial impact and ultimate impact. The Multi-Dimensional Scaling suggests the dimensions of peer feedback can be conceptualized in terms of relative emphasis on expertise vs. effort and on overall review quality vs. individual comment quality. The findings provide a new road map for meta-analyses, empirical studies, and system design work focused on peer feedback literacy.
Report of a semi-branched stent-graft to treat a type 1a endoleak after failed EVAR
Authors: Yazar Ozan , Wong ChunYu , Salemans Pieter Bartholomeus , van Wely Chrissy , Nouwens Ruben , van Grinsven Bart , Bouwman Lee Hans 
Published: April 2024

Abstract
Background
Endovascular techniques are advancing with the change of treatment paradigm for abdominal aortic aneurysms. Fenestrated EVAR (fEVAR) and branched EVAR (bEVAR) are used for complex aortic aneurysm repair. Both fEVAR and bEVAR have their own advantages and disadvantages. Semi-branches are a new feature that attempt to combine the advantages of both fEVAR and bEVAR.

Technique
We describe the use of a 4-vessel semi-branched EVAR in a failed EVAR case with a type 1a endoleak.

Conclusion
The novel feature of semi-branches in custom-made EVAR devices in endovascular aortic treatment following failed EVAR appear to be a feasible option.
Optimized diagnosis of local anomalies in charge and discharge of solar cell capacitors
Authors: Liu Xianhua , Liu Qinghong 
Published: April 2024

Abstract
Background
With the increasingly serious environmental pollution and natural environment damage, renewable energy such as solar cells have gradually become the key to change this situation. Therefore, the local abnormal diagnosis of the charge and discharge of solar cell capacitors is particularly important.

Objective
To extend the life of ultracapacitors by resolving the issue of their low detection rate and enhancing the capacity to recognize fault diagnosis factors. A novel approach to charging and discharging, as well as the diagnosis of local anomalies, is put forth, utilizing switching networks.

Methods
By controlling the capacitors of multiple solar cells and supercapacitors to work together, it is possible to compensate for the shortage of photovoltaic power. The performance of fault diagnosis is optimized by combining principal component analysis and binary K-means clustering, which completes the fault diagnosis of capacitors.

Results
The experimental results show that the research method can increase the maximum output power of photovoltaic by 32.9% under multi-layer shadows. In the charging state of the training set, the number of abnormal capacitors is 6, and the number of normal capacitors is 12, and both of them are in accordance with the preset value. The number of abnormal capacitors and normal capacitors in the discharge state is the same as that in the charging state, which is also 6 and 12.

Conclusion
The research method can effectively address the issue of unbalanced energy storage battery packs and minimize the impact of local shadows on photovoltaic systems. In comparison to fuzzy C-means clustering, this method requires fewer iterations, enables faster fault diagnosis, and produces more accurate clustering results. It can provide technical support for diagnosing local abnormalities in the charging and discharging of solar cell capacitors.
Addressing comprehensive complexities a striking familial hypercholesterolemia case study
Authors: Rasheed Shazia , Kubra Ghulam , Baqai Lubna , Raza Muhammad Liaquat , Hassan Fariha , Rizvi Syed Ghazi Abbas 
Published: April 2024

Abstract
Background
Premature aortic involvement and comprehensive management strategies in familial hypercholesterolemia familial hypercholesterolemia (FH), a rare autosomal dominant genetic disorder, poses significant challenges due to its propensity for elevated low-density lipoprotein cholesterol, premature coronary heart disease, and vascular atherosclerosis.

Case presentation
Unraveling Cardiovascular Complexities: A Striking Familial Hypercholesterolemia. This case study delves into a remarkable instance of FH in a 16-year-old female who presented with chest pain and worsening dyspnea. Diagnostic evaluation revealed distinct electrocardiographic changes, elevated troponin levels, and profound dyslipidemia. Remarkable findings on transthoracic echocardiography, computed tomography angiography, and catheterization prompted multidisciplinary interventions and demonstrated remarkable enhancements in ventricular function, mitral regurgitation, and aortic stenosis.

Conclusion
The case study underscores the urgency of comprehensive management strategies in confronting the myriad challenges of FH, emphasizing the value of early intervention, innovative therapies, and rigorous imaging modalities for unraveling the intricate cardiovascular manifestations of this condition.
A proposed multidimensional model for predicting financial distress: an empirical study on Egyptian listed firms
Authors: Abdelkader Noha Adel Mohamed , Wahba Hayam Hassan 
Published: April 2024

AbstractAlthough there has been a growing interest by researchers worldwide over the past decades to identify the factors pertaining to corporate financial distress and to develop financial distress prediction models that serve as early warning signs to the various firm stakeholders, notably to date, studies that were conducted were context specific and cannot be objectively generalized to other countries and rendered mixed inconclusive results. Therefore, the main objective of this study is to thoroughly investigate the factors that affect corporate financial distress in Egypt and to develop a multidimensional financial distress prediction model. Using comprehensive data of EGX100 listed firms, the researcher examines the role played by financial ratios, market-based indicators, macroeconomic factors, and corporate governance mechanisms in modeling corporate financial distress. Empirical results indicate that after controlling for the COVID-19 effects, the most significant financial ratios in predicting corporate financial distress are the working capital to total assets ratio, earnings before interest and taxes to total assets ratio, and the sales to total assets ratio. Such ratios are negatively related to the likelihood of corporate financial distress. However, the market value of equity to total liabilities ratio, and GDP growth rate have a positive impact on the likelihood of financial distress. However, the retained earnings to total assets ratio, the corporate governance mechanisms, the firm market capitalization, the interest rate, and the consumer price index are insignificant in predicting corporate financial distress in the Egyptian context. The resulting model demonstrates outstanding classification accuracy at around 96%.
Estrogen Receptor Alpha Mutations, Truncations, Heterodimers, and Therapies
Authors: Hancock Govinda R , Gertz Jason , Jeselsohn Rinath , Fanning Sean W 
Published: April 2024

Abstract
Annual breast cancer (BCa) deaths have declined since its apex in 1989 concomitant with widespread adoption of hormone therapies that target estrogen receptor alpha (ERα), the prominent nuclear receptor expressed in ∼80% of BCa. However, up to ∼50% of patients who are ER+ with high-risk disease experience post endocrine therapy relapse and metastasis to distant organs. The vast majority of BCa mortality occurs in this setting, highlighting the inadequacy of current therapies. Genomic abnormalities to ESR1, the gene encoding ERα, emerge under prolonged selective pressure to enable endocrine therapy resistance. These genetic lesions include focal gene amplifications, hotspot missense mutations in the ligand binding domain, truncations, fusions, and complex interactions with other nuclear receptors. Tumor cells utilize aberrant ERα activity to proliferate, spread, and evade therapy in BCa as well as other cancers. Cutting edge studies on ERα structural and transcriptional relationships are being harnessed to produce new therapies that have shown benefits in patients with ESR1 hotspot mutations. In this review we discuss the history of ERα, current research unlocking unknown aspects of ERα signaling including the structural basis for receptor antagonism, and future directions of ESR1 investigation. In addition, we discuss the development of endocrine therapies from their inception to present day and survey new avenues of drug development to improve pharmaceutical profiles, targeting, and efficacy.
Cinematic Independence: Constructing the Big Screen in Nigeria, Noah Tsika (2022)
Authors: Azuawusiefe Chijioke 
Published: April 2024

Review of: Cinematic Independence: Constructing the Big Screen in Nigeria, Noah Tsika (2022)
Oakland, CA: University of California Press, 262 pp.,
ISBN 978-0-52038-609-9, p/bk, $34.95