bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early determination of clopidogrel responsiveness by platelet reactivity index identifies patients at risk for cardiovascular events after myocardial infarction
Authors: Schäfer Andreas , Flierl Ulrike , Kössler Jürgen , Seydelmann Nora , Kobsar Anna , Störk Stefan , Bauersachs Johann 
Published: June 2011

SummaryWhile acute myocardial infarction (MI) is associated with impaired clopidogrel responsiveness, systematic evaluation is lacking due to the inability of functional aggregation-based assays to analyse clopidogrel responsiveness in the presence of glycoprotein IIb/IIIa inhibitors. Using the P2Y12-specific, non-aggregation-based platelet-reactivity-index (PRI) we assessed clopidogrel responsiveness in patients with acute MI. Clopidogrel responsiveness was determined 24 hours (h) after loading with 600 mg clopidogrel in 54 patients with acute MI admitted for coronary intervention. A PRI > 50% was considered as suboptimal inhibition. Overall response in MI patients was suboptimal with a median PRI of 58%. Diabetes, low high-density lipoprotein and pre-hospital clopidogrel loading were associated with impaired clopidogrel responsiveness. Patients loaded at first medical contact had a significantly weaker platelet inhibition by clopidogrel after 24 h (PRI 63%) compared to those loaded peri-interventionally (PRI 54%, p=0.014). Clinical outcome was assessed as a combination of cardiac death, non-fatal MI, stent thrombosis, ischaemic stroke, and urgent target vessel revascularisation after 12 months. The pre-selected cut-off of PRI ≤ 50% yielded a sensitivity of 87% at a specificity of 26%, whereas a PRI ≤ 57% determined by receiver-operating characteristics (ROC)-analysis yielded a sensitivity of 80% at a specificity of 56% (event rate: PRI ≤ 57%: 12.0%; PRI > 57%: 41.4%, p=0.0136). In conclusion, PRI detects clopidogrel responsiveness in acute MI patients requiring glycoprotein IIb/IIIa antagonism; and impaired clopidogrel responsiveness predisposes to clinical events. Pre-hospital clopidogrel loading was associated with impaired response and more adverse events challenging the concept of earliest oral clopidogrel loading in MI patients.
Platelet function following trauma
Authors: Solomon Cristina , Traintinger Stefan , Ziegler Bernhard , Hanke Alexander , Rahe-Meyer Niels , Voelckel Wolfgang , Schöchl Herbert 
Published: June 2011

SummaryPlatelets play a central role in coagulation. Currently, information on platelet function following trauma is limited. We performed a retrospective analysis of patients admitted to the emergency room (ER) at the AUVA Trauma Centre, Salzburg, after sustaining traumatic injury. Immediately after admission to the ER, blood was drawn for blood cell counts, standard coagulation tests, and platelet function testing. Platelet function was assessed by multiplate electrode aggregometry (MEA) using adenosine diphosphate (ADPtest), collagen (COLtest) and thrombin receptor activating peptide-6 (TRAPtest) as activators. The thromboelastometric platelet component, measuring the contribution of platelets to the elasticity of the whole-blood clot, was assessed using the ROTEM® device. The study included 163 patients, 79.7% were male, and the median age was 43 years. The median injury severity score was 18. Twenty patients (12.3%) died. Median platelet count was significantly lower among non-survivors than survivors (181,000/μl vs. 212,000/μl; p=0.01). Although platelet function defects were relatively minor, significant differences between survivors and non-survivors were observed in the ADPtest (94 vs. 79 U; p=0.0019), TRAPtest (136 vs. 115 U; p<0.0001), and platelet component (134 vs.103 MCEEXTEM – MCEFIBTEM; p=0.0012). Aggregometry values below the normal range for ADPtest and TRAPtest were significantly more frequent in non-survivors than in survivors (p=0.0017 and p=0.0002, respectively). Minor decreases in platelet function upon admission to the ER were a sign of coagulopathy accompanying increased mortality in patients with trauma. Further studies are warranted to confirm these results and investigate the role of platelet function in trauma haemostatic management.Note: This work was carried out at the AUVA Trauma Centre, Salzburg, Austria.
Rapid diagnosis of FHL3 by flow cytometric detection of intraplatelet Munc13-4 protein
Authors: Murata Yuuki , Yasumi Takahiro , Shirakawa Ryutaro , Izawa Kazushi , Sakai Hidemasa , Abe Junya , Tanaka Naoko , Kawai Tomoki , Oshima Koichi , Saito Megumu , Nishikomori Ryuta , Ohara Osamu , Ishii Eiichi , Nakahata Tatsutoshi , Horiuchi Hisanori , Heike Toshio 
Published: June 2011

AbstractFamilial hemophagocytic lymphohistiocytosis (FHL) is a potentially lethal genetic disorder of immune dysregulation that requires prompt and accurate diagnosis to initiate life-saving immunosuppressive therapy and to prepare for hematopoietic stem cell transplantation. In the present study, 85 patients with hemophagocytic lymphohistiocytosis were screened for FHL3 by Western blotting using platelets and by natural killer cell lysosomal exocytosis assay. Six of these patients were diagnosed with FHL3. In the acute disease phase requiring platelet transfusion, it was difficult to diagnose FHL3 by Western blot analysis or by lysosomal exocytosis assay. In contrast, the newly established flow cytometric analysis of intraplatelet Munc13-4 protein expression revealed bimodal populations of normal and Munc13-4–deficient platelets. These findings indicate that flow cytometric detection of intraplatelet Munc13-4 protein is a sensitive and reliable method to rapidly screen for FHL3 with a very small amount of whole blood, even in the acute phase of the disease.
Post-discharge management following hip fracture - get you back to B4: A parallel group, randomized controlled trial study protocol
Authors: Cook Wendy L , Khan Karim M , Bech Michelle H , Brasher Penelope M , Brown Roy A , Bryan Stirling , Donaldson Meghan G , Guy Pierre , Hanson Heather M , Leia Cheryl , Macri Erin M , Sims-Gould Joanie , McKay Heather A , Ashe Maureen C 
Published: June 2011

Abstract

Background
Fall-related hip fractures result in significant personal and societal consequences; importantly, up to half of older adults with hip fracture never regain their previous level of mobility. Strategies of follow-up care for older adults after fracture have improved investigation for osteoporosis; but managing bone health alone is not enough. Prevention of fractures requires management of both bone health and falls risk factors (including the contributing role of cognition, balance and continence) to improve outcomes.

Methods/Design
This is a parallel group, pragmatic randomized controlled trial to test the effectiveness of a post-fracture clinic compared with usual care on mobility for older adults following their hospitalization for hip fracture. Participants randomized to the intervention will attend a fracture follow-up clinic where a geriatrician and physiotherapist will assess and manage their mobility and other health issues. Depending on needs identified at the clinical assessment, participants may receive individualized and group-based outpatient physiotherapy, and a home exercise program. Our primary objective is to assess the effectiveness of a novel post-discharge fracture management strategy on the mobility of older adults after hip fracture.
We will enrol 130 older adults (65 years+) who have sustained a hip fracture in the previous three months, and were admitted to hospital from home and are expected to be discharged home. We will exclude older adults who prior to the fracture were: unable to walk 10 meters; diagnosed with dementia and/or significant comorbidities that would preclude their participation in the clinical service.
Eligible participants will be randomly assigned to the Intervention or Usual Care groups by remote allocation. Treatment allocation will be concealed; investigators, measurement team and primary data analysts will be blinded to group allocation. Our primary outcome is mobility, operationalized as the Short Physical Performance Battery at 12 months. Secondary outcomes include frailty, rehospitalizations, falls risk factors, quality of life, as well as physical activity and sedentary behaviour. We will conduct an economic evaluation to determine health related costs in the first year, and a process evaluation to ascertain the acceptance of the program by older adults, as well as clinicians and staff within the clinic.

Trial registration number
ClinicalTrials.gov: NCT01254942
Controlled Switching of the T402 Transformer in the Križovany 400kV Substation
Authors: Janíček František , Mucha Martin , Česnek Karol , Kováčik Jozef 
Published: June 2011

Controlled Switching of the T402 Transformer in the Križovany 400kV Substation
The paper deals with simulating the circumstances of switching surge and trigger current at switching-in of the T402 autotransformer recently installed in Križovany, with the tests conducted by means of ATP (Alternative Transient Program) simulation software for simulating transient electromagnetic phenomena. The target has been to determine temporal curves for the most critical surge instances against earth and between the phases and the curves for trigger current with and without surge limiters connected, and to determine by means of simulations the size and statistical frequency of switching surges and based on a controlled switching simulation, to describe the elimination of transient phenomena during the process and in reference to the simulations and to operating manual for the PSD02 Siemens control unit, suggest the required configuration settings for the unit.
A Framework for Translating a High Level Security Policy into Low Level Security Mechanisms
Authors: Hassan Ahmed , Bahgat Waleed 
Published: June 2011

A Framework for Translating a High Level Security Policy into Low Level Security MechanismsSecurity policies have different components; firewall, active directory, and IDS are some examples of these components. Enforcement of network security policies to low level security mechanisms faces some essential difficulties. Consistency, verification, and maintenance are the major ones of these difficulties. One approach to overcome these difficulties is to automate the process of translation of high level security policy into low level security mechanisms. This paper introduces a framework of an automation process that translates a high level security policy into low level security mechanisms. The framework is described in terms of three phases; in the first phase all network assets are categorized according to their roles in the network security and relations between them are identified to constitute the network security model. This proposed model is based on organization based access control (OrBAC). However, the proposed model extend the OrBAC model to include not only access control policy but also some other administrative security policies like auditing policy. Besides, the proposed model enables matching of each rule of the high level security policy with the corresponding ones of the low level security policy. Through the second phase of the proposed framework, the high level security policy is mapped into the network security model. The second phase could be considered as a translation of the high level security policy into an intermediate model level. Finally, the intermediate model level is translated automatically into low level security mechanism. The paper illustrates the applicability of proposed approach through an application example.
Design of Robust Guaranteed Cost PID Controller for Networked Control Systems
Authors: Nguyen Quang , Veselý Vojtech 
Published: June 2011

Design of Robust Guaranteed Cost PID Controller for Networked Control SystemsThe paper addresses the problem of an output feedback guaranteed cost controller design for Networked Control Systems (NCSs) with time-delay and polytopic uncertainties. By constructing a new parameter-dependent Lyapunov functional and applying the free-weighting matrices technique, the parameter-dependent, delay-dependent design method will be obtained to synthesize PID controllers achieving a guaranteed cost such that the NCSs can be stabilized for all admissible uncertainties and time-delays. Finally, numerical examples are given to illustrate the effectiveness of the proposed method.
A Localized Recursive Estimation Algorithm for Vector Parameter Estimation in AD HOC Wireless Sensor Networks
Authors: Rastegarnia Amir , Tinati Mohammad , Mozaffari Behzad , Khalili Azam 
Published: June 2011

A Localized Recursive Estimation Algorithm for Vector Parameter Estimation in AD HOC Wireless Sensor NetworksIn this paper a localized recursive estimation scheme for vector parameter estimation in ad hoc wireless sensor networks (WSNs) is proposed. In our setup, each sensor has a noisy measurement from a fixed, but unknown vector parameter. The classical best linear unbiased estimator (BLUE) cannot be implemented in a practical ad hoc sensor network due to its requirement to transmit all real-valued messages to a fusion center (FC). To address this problem, in this paper we propose a recursive estimation algorithm which is based on progressive cooperation between sensors. In our proposed algorithm, each sensor computes an estimate of the unknown parameter using its own local data and some information from prior sensor. The computed estimate is delivered to the next sensor and so on. The last sensor delivers the computed estimate of the unknown parameter to the destination. Our mathematical analysis shows that the proposed recursive algorithm is an unbiased estimator of the unknown parameter and asymptotically approaches to the estimate that would be obtained if each sensor had access to the information across the entire network. Also, the simulation examples are used to show the performance of the proposed scheme.
Mathematical Modelling and Parameter Determination of Reluctance Synchronous Motor with Squirrel Cage
Authors: Hudák Peter , Hrabovcová Valéria 
Published: June 2011

Mathematical Modelling and Parameter Determination of Reluctance Synchronous Motor with Squirrel CageThe paper provides an analysis of reluctance synchronous motor (RSM) with asymmetrical rotor cage. Its performances during its starting up is investigated. A mathematical model is created on the basis of detailed investigation of model parameters. The RSM starting up by switching it directly across the line was simulated and verified by measurements.
Carbon Nanostructures Grown on Fe-Cr-Al Alloy
Authors: Čaplovičová Mária , Čaplovič Ľubomír , Búc Dalibor , Vinduška Peter , Janík Ján 
Published: June 2011

Carbon Nanostructures Grown on Fe-Cr-Al Alloy
The morphology and nanostructure of carbon nanotubes (CNTs), synthesized directly on Fe-Cr-Al-based alloy substrate using an alcohol catalytic chemical vapour deposition method (ACCVD), were examined by transmission electron microscopy (TEM). The grown CNTs were entangled with chain-like, bamboo-like, and necklace-like morphologies. The CNT morphology was affected by the elemental composition of catalysts and local instability of deposition process. Straight and bended CNTs with bamboo-like nanostructure grew mainly on γ-Fe and Fe3C particles. The synthesis of necklace-like nanostructures was influenced by silicon oxide, and growth of chain-like nanostructures was supported by a catalysts consisting of Fe, Si, oxygen and trace of Cr. Most of nanotubes grew according to base growth mechanism.
Synthesis of Carbon Nanostructures by Plasma Enhanced Chemical Vapour Deposition at Atmospheric Pressure
Authors: Jašek Ondřej , Synek Petr , Zajíčková Lenka , Eliáš Marek , Kudrle Vít 
Published: June 2011

Synthesis of Carbon Nanostructures by Plasma Enhanced Chemical Vapour Deposition at Atmospheric PressureCarbon nanostructures present the leading field in nanotechnology research. A wide range of chemical and physical methods was used for carbon nanostructures synthesis including arc discharges, laser ablation and chemical vapour deposition. Plasma enhanced chemical vapour deposition (PECVD) with its application in modern microelectronics industry became soon target of research in carbon nanostructures synthesis. Selection of the ideal growth process depends on the application. Most of PECVD techniques work at low pressure requiring vacuum systems. However for industrial applications it would be desirable to work at atmospheric pressure. In this article carbon nanostructures synthesis by plasma discharges working at atmospheric pressure will be reviewed.
Effect of Charge Recombination on the Fill Factor of Small Molecule Bulk Heterojunction Solar Cells
Authors: Zhang Yuan , Dang Xuan‐Dung , Kim Chunki , Nguyen Thuc‐Quyen 
Published: June 2011

AbstractSolution‐processed organic BHJ solar cells based on 3,6‐bis[5‐(benzofuran‐2‐yl)thiophen‐2‐yl]‐2,5‐bis(2‐ethylhexyl)pyrrolo[3,4‐c]pyrrole‐1,4‐dione (DPP(TBFu)2) or poly(3‐hexylthiophene) blended with [6,6]‐phenyl‐C60(70) ‐butyric acid methyl ester (PC60(70) BM) behave differently under various irradiation intensities. Small molecule‐based DPP(TBFu)2:PC60 BM solar cells show up to 5.2% power conversion efficiency and a high fill factor at low light intensity. At 100 mW cm−2 illumination, the efficiency and fill factor decrease, resulting in stronger power losses. Impedance spectroscopy at various light intensities reveals that high charge recombination is the cause of the low fill factor in DPP(TBFu)2:PC60 BM.
Design Principles of FRET‐Based Dye‐Sensitized Solar Cells with Buried Quantum Dot Donors
Authors: Itzhakov Stella , Buhbut Sophia , Tauber Elad , Geiger Thomas , Zaban Arie , Oron Dan 
Published: June 2011

AbstractIn this article, the physics of FRET is demonstrated for an architecture of dye‐sensitized solar cells, in which the quantum dot “antennas” that serve as donors are incorporated into the solid titania electrode, providing isolation from electrolyte quenching, and potentially increased photostability. The energy transferred to the dye acceptor from the quantum dot donor, in addition to the direct light absorption by the dye, finally induce dye excitation and electron injection to the metal oxide semiconductor electrode. We use time‐resolved photoluminescence measurements to directly show achievement of FRET efficiencies of up to 70%, corresponding to over 80% internal quantum efficiency when considering radiative energy transfer as well. The various parameters governing the FRET efficiency and the requirements for high efficiency FRET‐based cells are discussed. Since both buried donors inside the electrode and donors solubilized in the electrolyte have both been shown to achieve high energy transfer efficiencies, and as the two methods take advantage of different available volumes of the electrode to introduce donors providing the excess absorption, synergy of the two methods is highly promising for achieving panchromatic absorption within a thin electrode.
A Theoretical Study of Hydrogen Transfer Catalyzed by an IrIII PC(sp3)P Pincer Complex
Authors: Kozuch Sebastian , Azerraf Clarite 
Published: June 2011

AbstractA hydrogen transfer mechanism catalyzed by an IrIII PC(sp3)P pincer complex was studied by using DFT, and its efficiency was estimated by using the energetic span model. With the pristine complex, a hydrogen abstraction pathway could not be found, since a ligand dissociation to generate a vacant site is energetically costly. However, a nucleophilic attack of an alkoxide base (present in the reaction mixture) on the carbonyl ligand to form a carboalkoxy ligand generated an anionic catalyst that could easily provide the free site. From there, a hydride abstraction from an isopropyl ion (iPrO−) followed by a hydride transfer to acetophenone resulted in an efficient catalytic cycle.
Intermittent Drying: Energy Expenditure and Product Quality
Authors: Kowalski S. J. , Pawlowski A. 
Published: June 2011

AbstractSeveral issues pertinent to intermittent drying of clay‐like materials were analyzed with respect to energy consumption, quality of dried products, and drying time. Experimental tests were performed on the cylindrically‐shaped kaolin samples for batch convective drying realized with both periodically alternated temperature and humidity of the drying air. To assess the benefits from intermittent drying, a series of tests were carried out at both parameters kept constant. The net energy necessary for material heating and moisture evaporation was numerically calculated based on the authors' model of drying kinetics, and related to the experimentally measured total electric energy consumption to evaluate the effectiveness of intermittent drying. The quality of dried samples was quantified in terms of crack intensity and magnitude. It was found that intermittent drying permits much better product quality with comparable drying time and energy consumption when drying occurs under constant conditions.
Manny's legacy: paying forward my personal therapy
Authors: Freeman Arthur 
Published: June 2011

AbstractThe lessons of childhood will often last a lifetime. Two lessons that I learned early in life were that loss can occur quickly, unexpectedly, and have monumental consequences such as when my father died when I was 9 years old. I also learned that losses can be assuaged or mitigated in many ways, not the least of which would be the replacement of my father with a father figure, who filled the needs of an adolescent and later an adult with a role model, keen insights, and emotional support. This article traces my experiences with personal therapy and addresses how lessons learned can be used and passed on to succeeding generations comprised of one's children and, in my case, my patients and students for the past 45 years. © 2011 Wiley Periodicals, Inc. J Clin Psychol: In Session 67:1–5, 2011.
Comparative analysis of two types of methanol dehydrogenase from Methylophaga aminisulfidivorans MPT grown on methanol
Authors: Kim Hee Gon , Han Gui Hwan , Kim Dockyu , Choi Jong‐Soon , Kim Si Wouk 
Published: June 2011

AbstractTwo types of methanol dehydrogenase (MDH) were obtained from a novel marine methylotrophic bacterium, Methylophaga aminisulfidivorans MPT, grown on methanol. Type I MDH consisted of two identical dimers of α (65.98 kDa) and β (7.58 kDa) subunits organized to form the α2β2tetramer. Type II MDH contained an additional MxaJ protein (27.86 kDa) and had more specific activity than type I MDH. The Km values of type I and II MDH for methanol under cytochrome cL reduction assay system were estimated to be 50.3 and 13.0 μM, respectively, and the isoelectric points of type I and II MDH were determined to be 5.4 and 5.8, respectively. The average molar ratios of α:β, α:MxaJ, and β:MxaJ in type II MDH were approximately 1:0.99, 1:0.41 and 1:0.42, respectively. Based on these results, the original conformation of the MDH of M. aminisulfidivorans MPTis most likely the α2β2‐MxaJ complex. During purification, the lysozyme and freeze‐thawing cell disruption method significantly increased the amount of type II MDH in the soluble fraction compared with strong physical disruption methods such as sonication and French Press. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)