bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing self-adaptation for efficient decision-making at run-time in streaming applications on multicores
Authors: Vogel Adriano , Danelutto Marco , Torquati Massimo , Griebler Dalvan , Fernandes Luiz Gustavo 
Published: June 2024

AbstractParallel computing is very important to accelerate the performance of computing applications. Moreover, parallel applications are expected to continue executing in more dynamic environments and react to changing conditions. In this context, applying self-adaptation is a potential solution to achieve a higher level of autonomic abstractions and runtime responsiveness. In our research, we aim to explore and assess the possible abstractions attainable through the transparent management of parallel executions by self-adaptation. Our primary objectives are to expand the adaptation space to better reflect real-world applications and assess the potential for self-adaptation to enhance efficiency. We provide the following scientific contributions: (I) A conceptual framework to improve the designing of self-adaptation; (II) A new decision-making strategy for applications with multiple parallel stages; (III) A comprehensive evaluation of the proposed decision-making strategy compared to the state-of-the-art. The results demonstrate that the proposed conceptual framework can help design and implement self-adaptive strategies that are more modular and reusable. The proposed decision-making strategy provides significant gains in accuracy compared to the state-of-the-art, increasing the parallel applications’ performance and efficiency.
Knowledge creation through maker practices and the role of teacher and peer support in collaborative invention projects
Authors: Davies Sini , Seitamaa-Hakkarainen Pirita , Hakkarainen Kai 
Published: June 2024

AbstractThis study analyzed collaborative invention projects by teams of lower-secondary (13–14-year-old) Finnish students. In invention projects, student teams design and make materially embodied collaborative inventions using traditional and digital fabrication technologies. This investigation focused on the student teams’ knowledge creation processes by examining how they applied maker practices (i.e., design process, computer engineering, product design, and science practices) in their co-invention projects and the effects of teacher and peer support. In our investigations, we relied on video data and on-site observations, utilizing and further developing visual data analysis methods. Our findings assist in expanding the scope of computer-supported collaborative learning (CSCL) research toward sociomaterially mediated knowledge creation, revealing the open-ended, nonlinear, and self-organized flow of the co-invention projects that take place around digital devices. Our findings demonstrate the practice-based, knowledge-creating nature of these processes, where computer engineering, product design, and science are deeply entangled with design practices. Furthermore, embodied design practices of sketching, practical experimenting, and working with concrete materials were found to be of the essence to inspire and deepen knowledge creation and advancement of epistemic objects. Our findings also reveal how teachers and peer tutor students can support knowledge creation through co-invention.
Investigating the impact of hearing loss on attentional networks among older individuals: an event-related potential study
Authors: Madashetty Sankalpa , Palaniswamy Hari Prakash , Rajashekhar Bellur 
Published: June 2024

AbstractAttention is a core cognitive domain crucial in facilitating day-to-day life. Using an attention network test (ANT) along with event-related potentials (ERPs) in older individuals with hearing loss would provide excellent information about the impact of hearing loss on attentional processes. Thus, the current study aims to understand the attentional deficits and its cortical dynamics in older individuals with and without hearing loss. The study recruited 40 participants, 20 older individuals with hearing loss and 20 age and education-matched controls with normal hearing. All the participants underwent cognitive assessment using ANT with simultaneous 32-channel EEG recording. Results revealed significant impairment in executive attention and subtle alterations in alerting and orienting attention among older individuals with hearing loss compared to their normal-hearing counterparts. These findings suggest the negative impact of hearing loss on attentional networks. In addition, ANT and ERPs provide insight into the underlying neural mechanisms in specific attention network deficits associated with hearing loss.
The Role of the Microbiome in Allergy, Asthma, and Occupational Lung Disease
Authors: Peer Ashley , Samuelson Derrick R. 
Published: June 2024

Abstract
Purpose of Review
The human commensal microbiota is now widely accepted as a key regulator of human health and disease. The composition of the mucosal associated microbiota has been shown to play a critical role in the lung health. The role of the mucosal microbiota in the development and severity of allergy, asthma, and occupational lung disease is only beginning to take shape. However, advances in our understanding of these links have tremendous potential to led to new clinical interventions to reduce allergy, asthma, and occupational lung disease morbidity.

Recent Findings
We review recent work describing the relationship and role of the commensal microbiota in the development of allergy, asthma, and occupational lung disease. Our review primarily focuses on occupational exposures and the effects of the microbiome, both in composition and function. Data generated from these studies may lead to the development of interventions targeted at establishing and maintaining a healthy microbiota. We also highlight the role of environmental exposures and the effects on the commensal microbial community and their potential association with occupational lung disease.

Summary
This review explores the current research describing the role of the human microbiome in the regulation of pulmonary health and disease, with a specific focus on the role of the mucosal microbiota in the development of allergy, asthma, and occupational lung disease.
Immune checkpoint inhibitors-associated thrombosis in patients with head and neck cancer: a study of the Spanish society of medical oncology (SEOM) thrombosis and cancer group
Authors: Sánchez Cánovas Manuel , Moya Hernández Miguel Ángel , Adoamnei Evdochia , Cacho Lavin Diego , Fernández Garay David , Quintanar Verdúguez Teresa , Rogado Revuelta Jacobo , García Verdejo Francisco José , García Adrián Silvia , Ferrer Pérez Ana Isabel , Guirao García María Esperanza , López Robles Javier , Mendiola Jaime , Muñoz Martín Andrés J. 
Published: June 2024

Abstract

Purpose
Both venous and arterial thrombotic events (VTE/AT) can be associated with Immune Checkpoint Inhibitors (ICI). However, there is a paucity of information apropos patients in routine clinical practice.

Methods
/Patients.
This retrospective, multicenter study was promoted by the Thrombosis and Cancer Section of the Spanish Society of Medical Oncology (SEOM). Individuals with head and neck cancer who initiated ICI between 01/01/2015 and 31/12/2021 were recruited. Minimum follow-up was 6 months (except in cases of demise).
The primary objective was to calculate the incidence of ICI-associated VTE/AT, with secondary objectives including the analysis of their impact on survival and the identification of variables predictive of VTE/AT.

Results
A total of 143 patients with head and neck cancer were enrolled. The incidence of VTE/AT during follow-up (median 8.6 months) was 2.8%. Survival analysis showed no significant differences (p = 0.644) between the group that developed VTE/AT (median 7.13 months, 95% CI 0–22.9) and the group that did not (median 9.86 months, 95% CI 6.3–13.4). The presence of liver metastases was predictive of VTE/AT (p < 0.05).

Conclusions
Thromboembolic disease associated with immunotherapy in patients with head and neck neoplasia does not significantly impact survival. The presence of liver metastases can predict these events.
EGMS-toolkit: a set of Python scripts for improved access to datasets from the European Ground Motion Service
Authors: Hrysiewicz Alexis , Khoshlahjeh Azar Mahdi , Holohan Eoghan P. 
Published: June 2024

AbstractContinental-scale, open-access datasets of ground surface displacement in all countries of the European Union, plus Norway, United Kingdom, and Iceland, are now available from the European Ground Motion Service (EGMS). Under the European Union’s Copernicus program, the EGMS has been available since the end of 2022 and will continue for the foreseeable future. The EGMS data are presently derived from Interferometric Synthetic Aperture Radar (InSAR) processing of the Sentinel-1 SAR satellite imagery, which has been collected from 2015 to date. While EGMS data can be visualised and obtained through an online platform (EGMS Explorer), the data access arrangements are inefficient for large-scale analysis of ground surface displacements due to the volume of data, the tile-formatting of datasets and some server limitations. Here we present a Python-based toolkit, named EGMS-toolkit, to provide a unified and more efficient workflow for accessing EGMS datasets. The toolkit can automatically detect and download EGMS datasets based on a Region of Interest provided by users, then it can merge, clip, and crop the results to that region regardless of its scale. The toolkit then produces files of EGMS ground surface motions in GIS-ready formats for further analysis.
Comparative Analysis of Seven Endogenous Hormones in a Novel Dual-axillary Bud Mutant Genotype of Sugarcane
Authors: Wickramasinghe Kamal Priyananda , Mao Jun , Xu Chao-hua , Lin Xiu-qin , Li Xu-juan , Qin Wei , Liu Hong-bo , Liu Xin-long , Mehdi Faisal , Zhao Pei-fang , Lu Xin 
Published: June 2024

AbstractThe sugarcane genotype YZ 07-86 is a distinct natural mutant with dual-axillary buds. Exploitation of this valuable trait in sugarcane breeding requires an understanding of the physiological mechanism of dual-axillary bud formation. This experiment determined the contents of indole-3-acetic acid (IAA), abscisic acid (ABA), gibberellins (GA3 and GA4), and three cytokinins (CKs), namely isopentenyl adenosine (iPA), zeatin riboside (ZR), and dihydrozeatin riboside (DHZR), in the shoot apical meristem tissues of YZ 07-86 and its sister line YZ 07-87, which served as the control genotype. The field experiment followed a completely randomized design with three replications for each genotype. Sampling was done at 5-day intervals, starting 106 days after planting. The ELISA technique was used to measure the contents of endogenous hormones. The study revealed that the mean contents of IAA, GA3, GA4, DHZR, and iPA were not significantly different (P > 0.05) among the genotypes. Conversely, in YZ 07-86, the mean ZR content was significantly higher (P < 0.05), and the mean ABA content was significantly lower than in the control genotype. Moreover, the mean content ratios of ZR/IAA, ZR/ABA, ZR/GA3, and ZR/GA4 were also significantly higher in YZ 07-86. The study concludes that elevated ZR content and an increased ZR/ABA ratio directly contributes to dual-axillary bud formation in YZ 07-86, offering valuable insights for the advancement of sugarcane genotypes.
Optical dromions with polarization–mode dispersion having parabolic law of self–phase modulation with multiplicative white noise
Authors: Zayed Elsayed M. E. , Alurrfi Khaled A. E. , El–Shater Mona , Biswas Anjan , Yildirim Yakup , Rawal Bharat S. , Alshomrani Ali Saleh 
Published: June 2024

AbstractThis article studies optical dromions with spatio–temporal dispersion having parabolic law of nonlinear refractive index change in presence of white noise. Two integration approaches reveal the dromion solutions. They are the extended auxiliary equation approach and the generalized projective Riccati equation scheme. A wide spectrum of dromion solution structures have been revealed from such algorithms. The parameter constraints are also enlisted for these dromions to exist.
A Probe in to Site Occupancy of Uranium in Barium Aluminium Borate (BaAl2B2O7) Matrix by EXAFS and its Photoluminescence Studies
Authors: Rout Annapurna , Jha S. K. , Nayak C. , Bhattacharyya D. , Jha S. N. 
Published: June 2024

AbstractA host matrix with a potential of incorporating heavy element like uranium, that have several forms of stabilization is the key interest. Uranium-doped BaAl2B2O7 is synthesized through solution combustion synthesis method. The luminescence studies indicate suitability of this alumino borate matrix to stabilize uranium as uranate (UO66−). The uranium life-time values suggest uranium to be surrounded by two different environments with varied defect concentration. The site occupancy of uranium in BaAl2B2O7 is probed through EXAFS studies. It is observed that the preferred sites for uranium incorporation is the Al3+ regular lattice sites.
BOLERO-5: a phase II study of everolimus and exemestane combination in Chinese post-menopausal women with ER + /HER2- advanced breast cancer
Authors: Shao Zhi-Ming , Cai Li , Wang Shusen , Hu Xichun , Shen Kunwei , Wang Haibo , Li Huiping , Feng Jifeng , Liu Qiang , Cheng Jing , Wu Xinhong , Wang Xiaojia , Li Hongyuan , Luo Ting , Liu Jinping , Amin Khalid , Slimane Khemaies , Qiao Yongping , Liu Yongmin , Tong Zhongsheng 
Published: June 2024

Abstract
Background
The global BOLERO-2 trial established the efficacy and safety of combination everolimus (EVE) and exemestane (EXE) in the treatment of estrogen receptor positive (ER +), HER2-, advanced breast cancer (ABC). BOLERO-5 investigated this combination in a Chinese population (NCT03312738).

Methods
BOLERO-5 is a randomized, double-blind, multicenter, placebo controlled, phase II trial comparing EVE (10 mg/day) or placebo (PBO) in combination with EXE (25 mg/day). The primary endpoint was progression-free survival (PFS) per investigator assessment. Secondary endpoints included PFS per blinded independent review committee (BIRC), overall survival (OS), overall response rate (ORR), clinical benefit rate (CBR), pharmacokinetics, and safety.

Results
A total of 159 patients were randomized to EVE + EXE (n = 80) or PBO + EXE (n = 79). By investigator assessment, treatment with EVE + EXE prolonged median PFS by 5.4 months (HR 0.52; 90% CI 0.38, 0.71), from 2.0 months (PBO + EXE; 90% CI 1.9, 3.6) to 7.4 months (EVE + EXE; 90% CI 5.5, 9.0). Similar results were observed following assessment by BIRC, with median PFS prolonged by 4.3 months. Treatment with EVE + EXE was also associated with improvements in ORR and CBR. No new safety signals were identified in BOLERO-5, with the incidence of adverse events in Chinese patients consistent with the safety profile of both drugs.

Conclusion
The efficacy and safety results of BOLERO-5 validate the findings from BOLERO-2, and further support the use of EVE + EXE in Chinese post-menopausal women with ER + , HER2- ABC. NCT03312738, registered 18 October 2017.
Establishment and validation of a novel disulfidptosis-related immune checkpoint gene signature in clear cell renal cell carcinoma
Authors: Du Lihuan , Zhang Nan , Wang Bohan , Cheng Wei , Wen Jiaming 
Published: June 2024

Abstract
Background
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal tumors and is associated with a unfavorable prognosis. Disulfidptosis is a recently identified form of cell death mediated by disulfide bonds. Numerous studies have highlighted the significance of immune checkpoint genes (ICGs) in ccRCC. Nevertheless, the involvement of disulfidptosis-related immune checkpoint genes (DRICGs) in ccRCC remains poorly understood.

Methods
The mRNA expression profiles and clinicopathological data of ccRCC patients were obtained from The Cancer Genome Atlas and Gene Expression Omnibus (GEO) databases. The associations between disulfidptosis-related genes (DRGs) and immune checkpoint genes (ICGs) were assessed to identify DRICGs. Cox regression analysis and least absolute shrinkage and selection operator (LASSO) analysis were conducted to construct a risk signature.

Results
A total of 39 differentially expressed immune-related candidate genes were identified. A prognostic signature was constructed utilizing nine DRICGs (CD276, CD80, CD86, HLA-E, LAG3, PDCD1LG2, PVR, TIGIT, and TNFRSF4) and validated using GEO data. The risk model functioned as an independent prognostic indicator for ccRCC, while the associated nomogram provided a reliable scoring system for ccRCC. Gene set enrichment analysis indicated enrichment of phospholipase D, antigen processing and presentation, and ascorbate and aldarate metabolism-related signaling pathways in the high-risk group. Furthermore, the DRICGs exhibited correlations with the infiltration of various immune cells. It is noteworthy that patients with ccRCC categorized into distinct risk groups based on this model displayed varying sensitivities to potential therapeutic agents.

Conclusions
The novel DRICG-based risk signature is a reliable indicator for the prognosis of ccRCC patients. Moreover, it also aids in drug selection and correlates with the tumour immune microenvironment in ccRCC.
PARP1 bound to XRCC2 promotes tumor progression in colorectal cancer
Authors: Xu Kaiwu , Yu Zhige , Lu Tailiang , Peng Wei , Gong Yongqiang , Chen Chaowu 
Published: June 2024

Abstract
Background
By complexing poly (ADP-ribose) (PAR) in reaction to broke strand, PAR polymerase1 (PARP1) acts as the key enzyme participated in DNA repair. However, recent studies suggest that unrepaired DNA breaks results in persistent PARP1 activation, which leads to a progressively reduce in hexokinase1 (HK1) activity and cell death. PARP-1 is TCF-4/β-A novel co activator of gene transactivation induced by catenin may play a role in the development of colorectal cancer. The molecular mechanism of PARP1 remains elusive.

Methods
212 colorectal cancer (CRC) patients who had the operation at our hospital were recruited. PARP1 expression was evaluated by immunohistochemistry. Stable CRC cell lines with low or high PARP1 expression were constructed. Survival analysis was computed based on PARP1 expression. The cell proliferation was tested by CCK-8 and Colony formation assay. The interaction of PARP1 and XRCC2 was detected by immunoprecipitation (IP) analysis.

Results
Compared with matching adjacent noncancerous tissue, PARP1 was upregulated in CRC tissue which was correlated with the degree of differentiation, TNM stage, depth of invasion, metastasis, and survival. In addition, after constructing CRC stable cell lines with abnormal expression of PARP1, we found that overexpression of PARP1 promoted proliferation, and demonstrated the interaction between PARP1 and XRCC2 in CRC cells through immunoprecipitation (IP) analysis. Moreover, the inhibitor of XRCC2 can suppress the in vitro proliferation arousing by upregulation of PARP1.

Conclusions
PARP1 was upregulated in CRC cells and promoted cell proliferation. Furthermore, the expression status of PARP1 was significantly correlated with some clinicopathological features and 5-year survival.
Photosynthetic response to a winter heatwave in leading and trailing edge populations of the intertidal red alga Corallina officinalis (Rhodophyta)
Authors: Kolzenburg Regina , Ragazzola Federica , Tamburello Laura , Nicastro Katy R. , McQuaid Christopher D. , Zardi Gerardo I. 
Published: June 2024

AbstractMarine heatwaves (MHWs) caused by anthropogenic climate change are becoming a key driver of change at the ecosystem level. Thermal conditions experienced by marine organisms across their distribution, particularly towards the equator, are likely to approach their physiological limits, resulting in extensive mortality and subsequent changes at the population level. Populations at the margins of their species’ distribution are thought to be more sensitive to climate-induced environmental pressures than central populations, but our understanding of variability in fitness-related physiological traits in trailing versus leading-edge populations is limited. In a laboratory simulation study, we tested whether two leading (Iceland) and two trailing (Spain) peripheral populations of the intertidal macroalga Corallina officinalis display different levels of maximum potential quantum efficiency (Fv/Fm) resilience to current and future winter MHWs scenarios. Our study revealed that ongoing and future local winter MHWs will not negatively affect leading-edge populations of C. officinalis, which exhibited stable photosynthetic efficiency throughout the study. Trailing edge populations showed a positive though non-significant trend in photosynthetic efficiency throughout winter MHWs exposure. Poleward and equatorward populations did not produce significantly different results, with winter MHWs having no negative affect on Fv/Fm of either population. Additionally, we found no long-term regional or population-level influence of a winter MHWs on this species’ photosynthetic efficiency. Thus, we found no statistically significant difference in thermal stress responses between leading and trailing populations. Nonetheless, C. officinalis showed a trend towards higher stress responses in southern than northern populations. Because responses rest on a variety of local population traits, they are difficult to predict based solely on thermal pressures.
AI in Healthcare and the Public Sector: How to Face the Challenges of High-Risk Applications and What AI Research Can Get Out of It
Authors: Braun Tanya , Möller Ralf 
Published: June 2024

AbstractApplication projects, may it be in healthcare and the public sector or elsewhere, have the potential to advance foundational (“genuine”) artificial intelligence (AI) research. Unfortunately, insights from specific application projects are rarely propagated back to AI research. This article argues for ways to facilitate such backpropagation and how the contributions in this special issue enable exactly this backpropagation. It also addresses the challenges that come along with high-risk application project, which frequently occur in the area of healthcare and the public sector due to the sensitivity of the subjects.
Integrating vertidrome management tasks into U-space
Authors: Schuchardt Bianca I. , Devta Aditya , Volkert Andreas 
Published: June 2024

AbstractU-space as defined by the European Commission is a set of new services relying on a high level of digitalization and automation of functions and specific procedures, designed to provide safe, efficient, and secure access to airspace for large numbers of unmanned aircraft, operating automatically and even beyond visual line of sight. This kind of concepts of operations (ConOps) of airspace integration for drones and air taxis are also called UTM (unmanned aircraft system traffic management) systems, being U-space the UTM ConOps agreed for Europe. U-space services are under development but commercially not available yet. For demonstration purposes, in the project HorizonUAM, a central U-space cloud service is simulated through a local messaging server using the protocol MQTT (message queuing telemetry transport). A prototypical vertidrome management tool was created to demonstrate the scheduling and sequencing of air taxi flights. The vertidrome manager is fully integrated within U-space and receives real-time information on flight plans, including requests for start and landing and emergency notifications. Additional information coming from other U-space services (e.g., weather information) can be accessed on request. The integration was demonstrated in a scaled flight test environment with multicopters (< 15 kg) representing passenger carrying air taxis.