bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of α‐Hydroxy‐1,2,3‐Triazole‐linked Sialyltransferase Inhibitors and Evaluation of Selectivity Towards ST3GAL1, ST6GAL1 and ST8SIA2
Authors: Szabo Rémi , Dobie Chris , Montgomery Andrew P. , Steele Harrison , Yu Haibo , Skropeta Danielle 
Published: May 2024

AbstractTumour‐derived sialoglycans, bearing the charged nonulosonic sugar sialic acid at their termini, play a critical role in tumour cell adhesion and invasion, as well as evading cell death and immune surveillance. Sialyltransferases (ST), the enzymes responsible for the biosynthesis of sialylated glycans, are highly upregulated in cancer, with tumour hypersialylation strongly correlated with tumour growth, metastasis and drug resistance. As a result, desialylation of the tumour cell surface using either targeted delivery of a pan‐ST inhibitor (or sialidase) or systemic delivery of a non‐toxic selective ST inhibitors are being pursued as potential new anti‐metastatic strategies against multiple cancers including pancreatic, ovarian, breast, melanoma and lung cancer. Herein, we have employed molecular modelling to give insights into the selectivity observed in a series of selective ST inhibitors that incorporate a uridyl ring in place of the cytidine of the natural donor (CMP‐Neu5Ac) and replace the charged phosphodiester linker of classical ST inhibitors with a neutral α‐hydroxy‐1,2,3‐triazole linker. The inhibitory activities of the nascent compounds were determined against recombinant human ST enzymes (ST3GAL1, ST6GAL1, ST8SIA2) showing promising activity and selectivity towards specific ST sub‐types. Our ST inhibitors are non‐toxic and show improved synthetic accessibility and drug‐likeness compared to earlier nucleoside‐based ST inhibitors.
CVO/TiO2 Heterojunction Photocatalyst for the Synthesis of Arylamines via Oxidative Aromatization of Amines and Cyclohexenones
Authors: Xu Sen , Liang Zeyao , Guo Jiabao , Lin Ping , Huang Zezhao , Zhu Li , Yao Xiaoquan 
Published: May 2024

AbstractA novel CVO/TiO2 heterojunction material has been prepared and used to catalyze the oxidative aromatization of amines and cyclohexenones under visible light irradiation, avoiding the use of noble metal catalysts and providing an environmentally friendly alternative for the synthesis of aromatic amines. The catalytic reaction uses oxygen as the final oxidant and provides good yields over a wide range of substrates. Notably, the recyclable heterogeneous semiconductor photocatalyst can be readily recovered and reused for at least four cycles. In addition, several biologically active molecules were successfully synthesized using the photocatalytic method.
Effect of Fluorine and Phosphorus Impurities in Phosphogypsum on Microstructure and Mechanism of α‐Type Hemihydrate Gypsum Crystals
Authors: Chen Xingyu , Shi Tianyao , Zhao Weidong , Li Yuefei 
Published: May 2024

AbstractIn this study, phosphogypsum (PG) is simulated by doping fluorine and phosphorus ions in an analytically pure reagent of gypsum dihydrate. The influence of fluorine and phosphorus impurity and content on the dehydration reaction process of phosphogypsum and its crystalline micromorphology is assessed during the preparation of α‐type gypsum hemihydrate in the reversed‐phase microemulsion system and its mechanism. The results show that when the fluorine content increases from 0 to 1.0 mol L−1 (ωNaF = 1.0 mol L−1), the dehydration process of dihydrate gypsum will be greatly slowed down. Scanning electron microscopy (SEM) analysis showed that even a small amount of F− (ωNaF = 0.2 mol L−1) can significantly inhibit the formation of α‐type hemi‐hydrated gypsum. When ωH3PO4 = 0.10 mol L−1, the water of crystallization content in the solid phase of the sample decreased to 5.24% after 90 min, which is significantly lower than during the same period of the benchmark group. However, there is a threshold value for the effect of phosphorus on the microscopic morphology of the α‐type gypsum hemihydrate crystals, when ωH3PO4 ≤ 0.04 mol L−1, the crystal morphology is basically unaffected. Moreover, when ωH3PO4 continued to increase, the defects on the crystal surface increased.
Plasma emission spectroscopy diagnosis of a direct current reverse‐brush electrode discharge
Authors: Lyu Xingbao , Li Zhiyong , Ma Yiqun , Wang Ying , Yuan Chengxun , Kudryavtsev Anatoly , Zhou Zhongxiang 
Published: May 2024

AbstractIn this work, emission spectra measurements from direct current (DC) reverse‐brush discharge plasmas were used to elucidate the energy level transition processes corresponding to each spectral line based on the mechanism of emission spectrum generation. The axial distribution patterns of the spectral line intensity and the electron excitation temperature in the electrode gap and post‐cathode space were systematically investigated. By comparing the acquired experimental results, it was observed that both the relative intensity of the plasma emission spectra and the electron excitation temperature in the electrode gap were higher than in the post‐cathode space, while their axial distribution trends exhibited an initial increase followed by a decrease. Additionally, the impact of the discharge gas pressure, reverse‐brush electrode thickness, and the number of electrode openings on the emission spectral line intensity and electron excitation temperature in the electrode gap were explored. Explanations for the underlying physical mechanisms were also provided.
A statistical integrative analysis method for microRNA and gene expression
Authors: Kodama Keita , Umezu Tomohiro , Fukuoka Yutaka 
Published: May 2024

AbstractMicroRNA (miRNA), a type of non‐coding RNA, is known to suppress the expression of target genes and there is an increasing number of studies analyzing various miRNAs in cancer. In an integrated analysis of miRNA and gene expressions, it is often difficult to obtain a significant result with a small amount of data. In this study, we proposed a method that allows integrated analysis even with a small amount of miRNA and gene expression data, and examined its validity. The method is based on a group comparison between target genes having specific functions controlled by a specific miRNA and a background group of randomly selected genes. We conducted a simulation to verify the validity of the proposed method. The simulation results indicated that the method can detect significant differences in expression of target genes controlled by a miRNA showing significant expression change. We then applied the proposed method to real data derived from multiple myeloma cells. As a result, some functions were detected as significantly changed due to a significant change of miRNA.
Critical linkages among floodplain hydrology, geomorphology and ecology along a lowland meandering river, Illinois, USA
Authors: Shukla Tanya , Salas Chelsy R. , Pankau Ryan C. , Rhoads Bruce L. 
Published: May 2024

AbstractThe ecology of forested floodplains is intricately linked to river hydrology through the frequency, magnitude, timing and duration of floodplain inundation. Spatial variability in inundation characteristics is influenced by the geomorphic template of a floodplain, both in terms of the topography of floodplain features and connectivity of these features to the main river channel. Spatial variability in inundation, in turn, has the potential to produce spatial variability in forest ecological characteristics. This study examines the influence of floodplain geomorphic features on spatial variability in inundation frequency as well as the relationship between these geomorphic features and the ecological characteristics of a floodplain forest. The frequencies of floods of different magnitudes are determined from flow‐duration analysis of over 100 years of discharge data for a lowland meandering river in Illinois, USA. Data on discharge, stage, and topography are then used to calibrate a two‐dimensional hydraulic model of flow across the floodplain at different levels of inundation. Integrating the frequency and inundation data yields mapping of average annual inundation frequency for different parts of the floodplain. Significant differences in inundation frequency correspond to three distinct floodplain geomorphic features: secondary channels (frequency = 12%), closed depressions (frequency = 4%) and the floodplain surface (frequency = 3%). Tree density is similar among the three types of geomorphic features, but tree species composition and canopy density differ significantly between secondary channels and the floodplain surface. The results provide insight into linkages among hydrology, geomorphology and tree characteristics of forested floodplains of lowland meandering rivers.
From social traditions to personalized routines: Maintenance goals as a resilience factor
Authors: Ecker Yael , Busch Alexandra W. , Schreiber Stefan , Imhoff Roland 
Published: May 2024

AbstractWe identified and tested a novel aspect of human resilience: The daily pursuit of maintenance goals. Taking inspiration from archaeological records, which point at routinized cultural practices as a central resilience factor, we tested whether personal routine practices, governed by maintenance goals, serve a similar function to individuals as traditional practices do to societies. Namely, we hypothesized that maintenance striving increases individuals’ resilient responses to stressful events. Confirming this prediction, a longitudinal Study 1 showed that maintenance striving but not avoidance striving, predicted subsequent increases in well‐being following the third wave of the COVID‐19 pandemic in Germany. Study 2 confirmed our predictions on trait resilience and maintenance versus avoidance motivations in the household and relationship life domains in cross‐sectional data. These studies contribute to the understanding of resilience by demonstrating the benefits of maintenance goals for both situational and trait‐level resilience.
Evaluation of a hybrid advanced oxidation process for removal of pirimicarb insecticide in aqueous media: Statistical optimization and estimation of electrical energy consumption
Authors: Ghavi Azam , Bagherian Ghadamali , Rezaei‐Vahidian Hadi 
Published: May 2024

AbstractIn this paper, the role of periodate and persulfate as inorganic oxidants were studied in presence of ultraviolet radiation and titanium dioxide nanoparticles as a hybrid advanced oxidation photocatalytic processes for degradation and mineralization of the pirimicarb insecticide in aqueous media. The effects of several factors such as the ultraviolet irradiation, initial oxidant concentration, titanium dioxide nanoparticles dosage, and pH on the process performance were investigated. The process optimization was performed by the central composite design as a tools of response surface methodology for 30 mg L−1 of the insecticide initial concentration at 25°C and 10 min of degradation process. A degradation efficiency of about 86% and 85% have been obtained for the persulfate and periodate processes, respectively, in the optimum conditions. The mineralization efficiency of the process using persulfate and periodate were about 35% and 46% after 60 min, respectively. The kinetic studies show that both processes follow a pseudo‐first‐order kinetic model and the rate constants were 0.1483 min−1 for the persulfate and 0.1152 min−1 for the periodate process. Generally, it can be concluded that this method is suitable for the degradation and mineralization of toxic aromatic compounds.
Coupled effects of heavy rainfall and falling water‐level exhibit the most significant influences on reservoir bank failures
Authors: Li Yihang , Xu Xiangzhou , Guo Shengli 
Published: May 2024

AbstractMass failures are often induced or activated by the variation of hydrological factors within a reservoir area. Clarifying the relationships between the failure volume and different hydrological factors may help to identify both the dominant factors influencing reservoir bank failures and the most hazardous combinations of factors inducing such events. This study examines the influence of different hydrological factors on bank failures using model experiments incorporating variations in rainfall, wave and water level. The results indicate that the coupled effects of heavy rainfall and falling water‐level had the most significant impact on bank failure. The cumulative failure mass of the reservoir bank peaked at 177.2 × 103 cm3 under the coupled effects of rainfall and falling water‐level. In comparison, the cumulative mass failures on the reservoir bank under rainfall superimposed onto waves and rainfall superimposed onto water level rise were 162.4 × 103 and 129.2 × 103 cm3, respectively. The impact of heavy rainfall significantly contributed the mass failures on soil reservoir bank. The analysis reveals that the highest cumulative failure, 106.3 × 103 cm3, occurred during periods of heavy rainfall. Compared with heavy rainfall, the cumulative failure volumes in the reservoir experienced a reduction of 46% and 55% under solely declining and solely rising reservoir water levels, respectively. The early phases of changing hydrological conditions have a significant effect on the stability of the soil reservoir bank. Mass failures on the bank predominantly occurred during the initial three events of the five simulation experiments performed for each landform, which could account for up to 87% of the total volume. Hence, it is advisable to avoid lowering reservoir water levels during periods of sustained heavy rainfall in order to mitigate the risk of bank failure.
Association depressive symptoms with memory function and social capital before and during COVID‐19 in community‐dwelling older adults in rural Japan: A retrospective study with a longitudinal data
Authors: Kunitake Yutaka , Imamura Yoshiomi , Kunitake Hiroko , Ohishi‐Fukuchi Junko , Matsushima Jun , Tateishi Hiroshi , Murakawa‐Hirachi Toru , Kojima Ryohei , Sakemura Yuta , Kikuchi Jun , Shiraishi Takumi , Takamori Ayako , Morisaki Toshihiro , Yamada Shigeto , Monji Akira , Mizoguchi Yoshito 
Published: May 2024

AbstractObjectivesThis study aimed to investigate the impact of memory function and social capital on depressive symptoms during the COVID‐19 pandemic among older adults in rural Japan.MethodsA retrospective study with longitudinal data was conducted during COVID‐19 from May 2021 to November 2021 (T2) in Kurogawa, Japan. The candidate population for this study was 145 with the following requirements: (1) older individuals aged 65 years or above who were registered in the Kurogawa study, and (2) those with previous data (from November 2016 to February 2020; T1 as pre‐pandemic). Memory function was assessed using the Wechsler Memory Scale‐Revised Logical Memory II delayed recall part A (LM II‐DR). Depressive symptoms were assessed using the Japanese version of the 15‐item Geriatric Depression Scale (GDS‐15). Social capital was evaluated through civic participation, social cohesion, and reciprocity. Fear of the COVID‐19 infection (FCV‐19S) was evaluated.ResultsThe final analysis included 96 participants (mean age = 81.0 years, SD = 4.8) Multivariate analysis for GDS‐15 score by Mixed Model Repeated Measures (MMRM) revealed significant associations between LM II‐DR (β = −0.13, 95% CI: −0.21–0.05, p = 0.002) and FCV‐19S during COVID‐19 (β = 0.08, 95% CI: 0.01–0.15, p = 0.02) with GDS‐15 score. However, civic participation, social cohesion and reciprocity were not associated with GDS‐15 score.ConclusionsAmong older adults in rural Japan, memory function and fear of the COVID‐19 infection were significantly associated with depressive symptoms in MMRM analysis. However, social capital was not associated with depressive symptoms. This highlights the need to address memory function and fear of the COVID‐19 infection in interventions for older adults during crises like the COVID‐19 pandemic.
A recipe for why and how to set up and sustain an experimental catchment
Authors: Penna Daniele 
Published: May 2024

AbstractExperimental catchments are fundamental elements in hydrological sciences as they provide key data for putting forward and testing hypotheses, developing theories, constraining models, and making predictions. Significant progress in catchment hydrology stemmed from field measurements but increasing costs and risks associated with field work and the availability of big data based on remote sensing, machine learning, and a plethora of models, as well as observations deriving from previous and current sites, raises questions on whether running an experimental catchment still provides individual and community benefits as in the past. In this commentary, I highlight the advantages of keeping experimental catchments alive and propose a personal 10‐step “recipe” to set up a new experimental catchment and manage and sustain it in the long term. These suggestions can be useful both to young and less young researchers who are open to facing the challenge of measuring processes in the field and are willing to offer the scientific community new experimental evidence for advancing our current knowledge in catchment hydrology.
DTM resolution controls the accuracy of estimating surface runoff indicators in flat, lowland landscapes
Authors: Schaap Peter , van der Velde Ype , de Louw Perry , Bartholomeus Harm 
Published: May 2024

AbstractSurface runoff plays an important role in contaminant transport, nutrient loss, soil erosion and peak discharges in streams and rivers. Because it is the result of a variety of complex hydrological processes, estimating surface runoff using physically based hydrological models is challenging. Upscaling of physical soil properties is necessary to cope with the limits of computational power in surface runoff modelling. In flat landscapes, the (micro)topographic surface controls the onset and progression of surface runoff on saturated soils during rain events. Therefore, its proper representation is crucial when attempting to model and predict surface runoff. In this study, the influence of microtopography (centimetre scale) on estimations of maximum depression storage (MDS), random roughness (RR) and the connectivity threshold (CT) is explored. These properties are selected because they often serve as surface runoff indicators in hydrological modelling. To characterize microtopography, a terrestrial laser scanner (TLS) is used to generate a digital terrain model (DTM) of the study site with a horizontal spatial resolution of 5 cm. MDS, RR and CT are then calculated and compared to the values generated from the publicly available Dutch national DTM dataset with a resolution of 50 cm. Our results show considerable differences in MDS, RR and CT when calculated for the different input resolution datasets. Using DTMs that do not sufficiently capture microtopography leads to underestimation of MDS and RR, and to overestimation of CT. Our findings indicate that surface runoff indicators, and thereby the surface runoff response of a saturated surface to rainfall events, are defined at scales smaller than the scales of typically available DTMs. Understanding surface runoff through modelling studies therefore requires a framework that accounts for this lack of information arising from using coarser resolution DTMs. We demonstrate a linear relationship between MDS values generated from the different resolution DTMs. This opens the possibility of using empirical scaling relationships between high‐ and lower‐resolution DTMs to account for microtopography. Repetition of our measurements on similar surfaces would contribute to establishing such empirical scaling relationships. Our results should be seen as indicative of flat landscapes and surfaces where centimetre scale microtopography is relevant.
Risk factors for intensive care unit admission after cesarean hysterectomy for placenta accreta spectrum
Authors: Munoz Jessian L. , Cheng CeCe , McCann Georgia A. , Ramsey Patrick , Byrne John J. 
Published: May 2024

AbstractObjectivePlacenta accreta spectrum (PAS) is a complex disorder of uterine wall disruption with significant morbidity and mortality, particularly at time of delivery. Both physician and physical hospital resource allocation/utilization remains a challenge in PAS cases including intensive care unit (ICU) beds. The primary objective of the present study was to identify preoperative risk factors for ICU admission and create an ICU admission prediction model for patient counseling and resource utilization decision making in an evidence‐based manner.MethodsThis was a case–control study of 145 patients at our PAS referral center undergoing cesarean hysterectomy for PAS. Final confirmation by histopathology was required for inclusion. Patient disposition after surgery (ICU vs post‐anesthesia care unit) was our primary outcome and pre‐/intra‐/postoperative variables were obtained via electronic medical records with an emphasis on the predictive capabilities of the preoperative variables. Uni‐ and multivariate analysis was performed to identify independent predictive factors for ICU admission.ResultsIn this large cohort of 145 patients who underwent cesarean hysterectomy for PAS, with histopathologic confirmation, 63 (43%) were admitted to the ICU following delivery. These patients were more likely to be delivered at an earlier gestational age (34 vs 35 weeks, P < 0.001), have had >2 episodes of vaginal bleeding and emergent delivery compared to patients admitted to patients with routine recovery care (44% vs 18.3%, P = 0.009). Uni‐ and multivariate logistic regression showed an area under the curve of 0.73 (95% CI: [0.63, 0.81], P < 0.001) for prediction of ICU admission with these three variables. Patients with all three predictors had 100% ICU admission rate.ConclusionResource prediction, utilization and allocation remains a challenge in PAS management. By identifying patients with preoperative risk factors for ICU admission, not only can patients be counseled but this resource can be requested preoperatively for staffing and utilization purposes.
Hibernoma in the renal sinus: A case mimicking malignancy
Authors: Kashima Ayano , Majima Tsuyoshi , Muramatsu Tomoaki , Kurosu Haruka , Kawanishi Hideji , Kobayashi Ikuo , Kajikawa Keishi , Takahara Taishi , Yamamoto Takahiro , Sassa Naoto 
Published: May 2024

IntroductionHibernomas are benign tumors of brown adipose tissue. Hibernoma in the renal sinus is extremely rare. Herein, we present the third known case of renal hibernoma.Case presentationA 71‐year‐old man reported to our department with a left kidney tumor with an average growth rate of 5 mm/year and a progressive contrast effect on computed tomography. It was diagnosed as a hibernoma following a laparoscopic radical nephrectomy.ConclusionWe encountered a rare case of a hibernoma in the renal sinus. Development of new and accurate diagnostic methods for hibernoma, without resorting to nephrectomy, is essential.