bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrically empowered microcomb laser
Authors: Ling Jingwei , Gao Zhengdong , Xue Shixin , Hu Qili , Li Mingxiao , Zhang Kaibo , Javid Usman A. , Lopez-Rios Raymond , Staffa Jeremy , Lin Qiang 
Published: May 2024

AbstractOptical microcomb underpins a wide range of applications from communication, metrology, to sensing. Although extensively explored in recent years, challenges remain in key aspects of microcomb such as complex soliton initialization, low power efficiency, and limited comb reconfigurability. Here we present an on-chip microcomb laser to address these key challenges. Realized with integration between III and V gain chip and a thin-film lithium niobate (TFLN) photonic integrated circuit (PIC), the laser directly emits mode-locked microcomb on demand with robust turnkey operation inherently built in, with individual comb linewidth down to 600 Hz, whole-comb frequency tuning rate exceeding 2.4 × 1017 Hz/s, and 100% utilization of optical power fully contributing to comb generation. The demonstrated approach unifies architecture and operation simplicity, electro-optic reconfigurability, high-speed tunability, and multifunctional capability enabled by TFLN PIC, opening up a great avenue towards on-demand generation of mode-locked microcomb that is of great potential for broad applications.
Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow
Authors: Ferreira-Gomes Marta , Chen Yidan , Durek Pawel , Rincon-Arevalo Hector , Heinrich Frederik , Bauer Laura , Szelinski Franziska , Guerra Gabriela Maria , Stefanski Ana-Luisa , Niedobitek Antonia , Wiedemann Annika , Bondareva Marina , Ritter Jacob , Lehmann Katrin , Hardt Sebastian , Hipfl Christian , Hein Sascha , Hildt Eberhard , Matz Mareen , Mei Henrik E. , Cheng Qingyu , Dang Van Duc , Witkowski Mario , Lino Andreia C. , Kruglov Andrey , Melchers Fritz , Perka Carsten , Schrezenmeier Eva V. , Hutloff Andreas , Radbruch Andreas , Dörner Thomas , Mashreghi Mir-Farzin 
Published: May 2024

AbstractBone marrow plasma cells (BMPC) are the correlate of humoral immunity, consistently releasing antibodies into the bloodstream. It remains unclear if BMPC reflect different activation environments or maturation of their precursors. Here we define human BMPC heterogeneity and track the recruitment of antibody-secreting cells (ASC) from SARS-CoV-2 vaccine immune reactions to the bone marrow (BM). Trajectories based on single-cell transcriptomes and repertoires of peripheral and BM ASC reveal sequential colonisation of BMPC compartments. In activated B cells, IL-21 suppresses CD19 expression, indicating that CD19low-BMPC are derived from follicular, while CD19high-BMPC originate from extrafollicular immune reactions. In primary immune reactions, both CD19low- and CD19high-BMPC compartments are populated. In secondary immune reactions, most BMPC are recruited to CD19high-BMPC compartments, reflecting their origin from extrafollicular reactivations of memory B cells. A pattern also observable in vaccinated-convalescent individuals and upon diphtheria/tetanus/pertussis recall-vaccination. Thus, BMPC diversity reflects the evolution of a given humoral immune response.
A scalable Li-Al-Cl stratified structure for stable all-solid-state lithium metal batteries
Authors: Su Han , Li Jingru , Zhong Yu , Liu Yu , Gao Xuhong , Kuang Juner , Wang Minkang , Lin Chunxi , Wang Xiuli , Tu Jiangping 
Published: May 2024

AbstractSulfides are promising electrolyte materials for all-solid-state Li metal batteries due to their high ionic conductivity and machinability. However, compatibility issues at the negative electrode/sulfide electrolyte interface hinder their practical implementation. Despite previous studies have proposed considerable strategies to improve the negative electrode/sulfide electrolyte interfacial stability, industrial-scale engineering solutions remain elusive. Here, we introduce a scalable Li-Al-Cl stratified structure, formed through the strain-activated separating behavior of thermodynamically unfavorable Li/Li9Al4 and Li/LiCl interfaces, to stabilize the negative electrode/sulfide electrolyte interface. In the Li-Al-Cl stratified structure, Li9Al4 and LiCl are enriched at the surface to serve as a robust solid electrolyte interphase and are diluted in bulk by Li metal to construct a skeleton. Enabled by its unique structural characteristic, the Li-Al-Cl stratified structure significantly enhances the stability of negative electrode/sulfide electrolyte interface. This work reports a strain-activated phase separation phenomenon and proposes a practical pathway for negative electrode/sulfide electrolyte interface engineering.
Fourier transform noise spectroscopy
Authors: Vezvaee Arian , Shitara Nanako , Sun Shuo , Montoya-Castillo Andrés 
Published: May 2024

AbstractSpectral characterization of noise environments that lead to the decoherence of qubits is critical to developing robust quantum technologies. While dynamical decoupling offers one of the most successful approaches to characterize noise spectra, it necessitates applying large sequences of π pulses that increase the complexity and cost of the method. Here, we introduce a noise spectroscopy method that utilizes only the Fourier transform of free induction decay or spin echo measurements, thus removing the need for the application many π pulses. We show that our method faithfully recovers the correct noise spectra for a variety of different environments (including 1/f-type noise) and outperforms previous dynamical decoupling schemes while significantly reducing their experimental overhead. We also discuss the experimental feasibility of our proposal and demonstrate its robustness in the presence of statistical measurement error. Our method is applicable to a wide range of quantum platforms and provides a simpler path toward a more accurate spectral characterization of quantum devices, thus offering possibilities for tailored decoherence mitigation.
Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial
Authors: Anter Elad , Mansour Moussa , Nair Devi G. , Sharma Dinesh , Taigen Tyler L. , Neuzil Petr , Kiehl Erich L. , Kautzner Josef , Osorio Jose , Mountantonakis Stavros , Natale Andrea , Hummel John D. , Amin Anish K. , Siddiqui Usman R. , Harlev Doron , Hultz Paul , Liu Shufeng , Onal Birce , Tarakji Khaldoun G. , Reddy Vivek Y. ,   SPHERE PER-AF Investigators, Reddy Vivek Y. 
Published: May 2024

AbstractClinical outcomes of catheter ablation for atrial fibrillation (AF) are suboptimal due, in part, to challenges in achieving durable lesions. Although focal point-by-point ablation allows for the creation of any required lesion set, this strategy necessitates the generation of contiguous lesions without gaps. A large-tip catheter, capable of creating wide-footprint ablation lesions, may increase ablation effectiveness and efficiency. In a randomized, single-blind, non-inferiority trial, 420 patients with persistent AF underwent ablation using a large-tip catheter with dual pulsed field and radiofrequency energies versus ablation using a conventional radiofrequency ablation system. The primary composite effectiveness endpoint was evaluated through 1 year and included freedom from acute procedural failure and repeat ablation at any time, plus arrhythmia recurrence, drug initiation or escalation or cardioversion after a 3-month blanking period. The primary safety endpoint was freedom from a composite of serious procedure-related or device-related adverse events. The primary effectiveness endpoint was observed for 73.8% and 65.8% of patients in the investigational and control arms, respectively (P < 0.0001 for non-inferiority). Major procedural or device-related complications occurred in three patients in the investigational arm and in two patients in the control arm (P < 0.0001 for non-inferiority). In a secondary analysis, procedural times were shorter in the investigational arm as compared to the control arm (P < 0.0001). These results demonstrate non-inferior safety and effectiveness of the dual-energy catheter for the treatment of persistent AF. Future large-scale studies are needed to gather real-world evidence on the impact of the focal dual-energy lattice catheter on the broader population of patients with AF. ClinicalTrials.gov identifier: NCT05120193.
Employing discrete global grid systems for reproducible data obfuscation
Authors: Caspari Gino , dos Santos Manuel João , Gago-Silva Ana , Jendryke Michael 
Published: May 2024

AbstractArchaeological heritage worldwide is threatened through deliberate destruction in particular site looting making the location of archaeological sites potentially sensitive data. At the same time, public information about site locations are important for heritage management, as well as agricultural and urban development. Finding a balance between revealing detailed site locations and not providing data at all is a difficult task. Here we provide an approach to obfuscate archaeological site location data facilitated through a Discrete Global Grid System. We then apply the new obfuscation method to the global p3k14c data set. Veiling the locations of heritage sites with a Discrete Global Grid System allows tiered accuracy access for different stakeholders tailored to their respective needs as well as legal constraints and requirements of administrations. Discrete Global Grid System based obfuscation is globally scalable, consistent, reproducible, and can address the current heterogeneity of obfuscation methods.
Identification of cancer risk groups through multi-omics integration using autoencoder and tensor analysis
Authors: Braytee Ali , He Sam , Tang Shuxian , Sun Yuxuan , Jiang Xiaoying , Yu Xuanding , Khatri Inder , Chaturvedi Kunal , Prasad Mukesh , Anaissi Ali 
Published: May 2024

AbstractIdentifying cancer risk groups by multi-omics has attracted researchers in their quest to find biomarkers from diverse risk-related omics. Stratifying the patients into cancer risk groups using genomics is essential for clinicians for pre-prevention treatment to improve the survival time for patients and identify the appropriate therapy strategies. This study proposes a multi-omics framework that can extract the features from various omics simultaneously. The framework employs autoencoders to learn the non-linear representation of the data and applies tensor analysis for feature learning. Further, the clustering method is used to stratify the patients into multiple cancer risk groups. Several omics were included in the experiments, namely methylation, somatic copy-number variation (SCNV), micro RNA (miRNA) and RNA sequencing (RNAseq) from two cancer types, including Glioma and Breast Invasive Carcinoma from the TCGA dataset. The results of this study are promising, as evidenced by the survival analysis and classification models, which outperformed the state-of-the-art. The patients can be significantly (p-value<0.05) divided into risk groups using extracted latent variables from the fused multi-omics data. The pipeline is open source to help researchers and clinicians identify the patients’ risk groups using genomics.
Antifungal activity of bio-active cell-free culture extracts and volatile organic compounds (VOCs) synthesised by endophytic fungal isolates of Garden Nasturtium
Authors: Santra Hiran Kanti , Dutta Riya , Banerjee Debdulal 
Published: May 2024

AbstractAntimicrobial resistance in fungal pathogens (both human and plant) is increasing alarmingly, leading to massive economic crises. The existing anti-fungal agents are becoming ineffective, and the situation worsens on a logarithmic scale. Novel antifungals from unique natural sources are highly sought to cope sustainably with the situation. Metabolites from endophytic microbes are the best-fitted alternatives in this case. Endophytes are the untapped sources of ‘plants’ internal microbial population’ and are promising sources of effective bio-therapeutic agents. Fungal endophytes were isolated from Tropaeolum majus and checked for antifungal activity against selected plant and human pathogens. Bioactive metabolites were identified through chromatographic techniques. The mode of action of those metabolites was evaluated through various spectroscopic techniques. The production of antifungal metabolite was optimized also. In particular VOCs (volatile organic compounds) of TML9 were tested in vitro for their anti-phytopathogenic activity. Ethyl acetate (EA) extract of cell-free culture components of Colletotrichum aenigma TML3 exhibited broad-spectrum antifungal activity against four species of Candida and the major constituents reported were 6-pentyl-2H-pyran-2-one, 2-Nonanone, 1 propanol 2-amino. The volatile metabolites, trans-ocimene, geraniol, and 4-terpinyl acetate, produced from Curvularia lunata TML9, inhibited the growth of some selected phyto pathogens. EA extract hampered the biofilm formation, minimised the haemolytic effect, and blocked the transformation of Candida albicans (MTCC 4748) from yeast to hyphal form with a Minimum Fungicidal Concentration (MFC) of 200–600 µg mL−1. Central carbohydrate metabolism, ergosterol synthesis, and membrane permeability were adversely affected and caused the lethal leakage of necessary macromolecules of C. albicans. Volatile metabolites inhibited the growth of phytopathogens i.e., Rhizoctonia solani, Alternaria alternata, Botrytis cinerea, Cercospora beticola, Penicillium digitatum, Aspergillus fumigatus, Ceratocystis ulmi, Pythium ultimum up to 89% with an IC50 value of 21.3–69.6 µL 50 mL−1 and caused leakage of soluble proteins and other intracellular molecules. Citrusy sweet odor volatiles of TML9 cultured in wheat-husk minimised the infections of Penicillium digitatum (green mold), in VOC-exposed sweet oranges (Citrus sinensis). Volatile and non-volatile antifungal metabolites of these two T. majus endophytes hold agricultural and pharmaceutical interests. Metabolites of TML3 have strong anti-Candida activity and require further assessment for therapeutic applications. Also, volatile metabolites of TML9 can be further studied as a source of antifungals. The present investigational outcomes bio-prospects the efficacy of fungal endophytes of Garden Nasturtium.
Examining the unsustainable relationship between SDG performance, ecological footprint and international spillovers
Authors: Moinuddin Mustafa , Olsen Simon Høiberg 
Published: May 2024

AbstractFor almost a decade, countries have been working to achieve the Sustainable Development Goals (SDGs). Yet progress on the SDGs across countries, as well as across the 17 goals, has proven frustratingly slow. Even countries that have performed relatively well on the SDGs may have done so by causing negative externalities, such as environmental degradation, in other parts of the world. To determine if this is the case empirically, we developed and tested hypotheses concerning how a country’s SDG performance is associated with such externalities. We then ran a regression to examine correlations between indices measuring SDG progress, ecological footprints and international spillovers. We found that SDG progress is positively correlated with increased ecological footprints and spillovers. The results indicate that SDG progress remains closely associated with conventional measures of economic growth, and that negative environmental and social impacts of internationally-sourced consumption represent behavioural and structural barriers to meaningful progress on sustainability.
Comparison of 8-vs-12 weeks, adapted dialectical behavioral therapy (DBT) for borderline personality disorder in routine psychiatric inpatient treatment—A naturalistic study
Authors: Kujovic Milenko , Benz Daniel , Riesbeck Mathias , Mollamehmetoglu Devin , Becker-Sadzio Julia , Margittai Zsofia , Bahr Christian , Meisenzahl Eva 
Published: May 2024

AbstractDialectical behavior therapy (DBT) is widely acknowledged as an effective treatment for individuals with borderline personality disorder (BPD). However, the optimal treatment duration within DBT remains a topic of investigation. This retrospective, naturalistic non-randomized study aimed to compare the efficacy of 8 week and 12 week DBT interventions with equivalent content, focusing on the change of BPD-specific symptomatology as the primary outcome and depressive symptoms as the secondary outcome. Overall, 175 patients who participated in DBT and received either 8 week or 12 week intervention were included in the analysis. Routine inpatient treatment was adapted from standard DBT with the modules: skill training, interpersonal skills, dealing with feelings, and mindfulness. Measurements were taken at baseline, mid-point, and endpoint. The borderline symptom list-23 (BSL-23) was used for the assessment of borderline-specific symptoms, while the Beck depression inventory-II (BDI-II) was used for the assessment of depressive symptoms. Statistical analysis was conducted using linear mixed models. Effect sizes were calculated for both measures. The results of the analysis indicated an improvement in both groups over time. Effect sizes were d = 1.29 for BSL-23 and d = 1.79 for BDI-II in the 8 week group, and d = 1.16 for BSL-23 and d = 1.58 for BDI-II in the 12 week group. However, there were no differences in the change of BPD-specific symptoms or the severity of depressive symptoms between the 8 week and 12 week treatment duration groups. Based on these findings, shorter treatment durations, like 8 weeks, could be a viable alternative, offering comparable therapeutic benefits, potential cost reduction, and improved accessibility. However, further research is needed to explore factors influencing treatment outcomes and evaluate the long-term effects of different treatment durations in DBT for BPD.Trial registration: drks.de (DRKS00030939) registered 19/12/2022.
Unveiling the electronic origin of lanthanide based Metal Organic Framework with ideal spin filtering capacity
Authors: Gastearena Xuban , Ugalde Jesus M. , Pieslinger German E. , San Sebastian Eider , Jimenez-Izal Elisa 
Published: May 2024

AbstractRecently, a three dimensional metal-organic framework (MOF) based on Dy(III) and the L-tartrate ligand was experimentally shown to exhibit a spin polarization (SP) power of 100% at room temperature. The material’s spin filtering ability was ascribed to the chiral-induced spin selectivity (CISS) effect. In this work, we computationally characterize the electronic structure of this MOF, revealing that the high SP of the material is linked to the asymmetric arrangement, around the Fermi level, of the alpha- and beta-spin electron states arising from the 4f-states of the lanthanide Dy atom, which results in two different conduction channels (band gaps) for each spin state. Based on the understanding gathered in this work, we propose that the substitution of the hydroxyl groups of the ligand by mercaptan groups should boost the electrical conductivity, while retaining the spin filtering power of the material.
Atmospheric destabilization leads to Arctic Ocean winter surface wind intensification
Authors: Zapponini Martina , Goessling Helge F. 
Published: May 2024

AbstractThe surface-amplified winter warming over the Arctic Ocean is accompanied by a pronounced intensification of near-surface winds, simulated by climate models and emerging in reanalysis data. Here, the influences of sea-ice decline, wind changes aloft, and atmospheric stability are revisited based on CMIP6 historical and high-emission scenario and ERA5 reanalysis data. Spatial trend patterns suggest that near-surface wind intensification over the inner Arctic Ocean in winter is largely driven by an increasing downward momentum transfer due to a weakening atmospheric stratification. In contrast, a near-surface wind intensification in summer appears to be largely driven by accelerating winds aloft, amplified in a high-emission future by decreasing surface roughness due to sea-ice decline. In both seasons, differences in near-surface wind-speed trends are closely linked to atmospheric stability trends. Models suggest that by 2100 the lower troposphere may become as unstable in winter as in summer, implying a fundamental regime shift of the Arctic winter boundary layer.
DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Authors: Liu Qianqian , Han Mingrui , Wu Zhigui , Fu Wenqiang , Ji Jun , Liang Qingqing , Tan Minjia , Zhai Linhui , Gao Jian , Shi Dongquan , Jiang Qing , Sun Ziying , Lai Yuping , Xu Qiang , Sun Yang 
Published: May 2024

AbstractHyaline cartilage fibrosis is typically considered an end-stage pathology of osteoarthritis (OA), which results in changes to the extracellular matrix. However, the mechanism behind this is largely unclear. Here, we found that the RNA helicase DDX5 was dramatically downregulated during the progression of OA. DDX5 deficiency increased fibrosis phenotype by upregulating COL1 expression and downregulating COL2 expression. In addition, loss of DDX5 aggravated cartilage degradation by inducing the production of cartilage-degrading enzymes. Chondrocyte-specific deletion of Ddx5 led to more severe cartilage lesions in the mouse OA model. Mechanistically, weakened DDX5 resulted in abundance of the Fn1-AS-WT and Plod2-AS-WT transcripts, which promoted expression of fibrosis-related genes (Col1, Acta2) and extracellular matrix degradation genes (Mmp13, Nos2 and so on), respectively. Additionally, loss of DDX5 prevented the unfolding Col2 promoter G-quadruplex, thereby reducing COL2 production. Together, our data suggest that strategies aimed at the upregulation of DDX5 hold significant potential for the treatment of cartilage fibrosis and degradation in OA.
The Role of Hypertension for Maternal Outcomes of Women with HELLP Syndrome – a Retrospective Study from a Tertiary Obstetric Center
Authors: Müller Linda-Marie , Eveslage Maria , Köster Helen Ann , Willy Kevin , Möllers Mareike , Schmitz Ralf , Oelmeier Kathrin , Willy Daniela 
Published: May 2024

AbstractHELLP syndrome is a serious disorder that can occur in pregnancy; it has many possible complications and is associated with adverse maternal outcome. Due to the lack of predictive parameters for HELLP syndrome, finding the right time for delivery is challenging. In contrast to preeclampsia, hypertension is not an essential part of the diagnosis; nevertheless, many women with HELLP syndrome are hypertensive. The role and possible implications of hypertension in HELLP syndrome are not fully understood.In this retrospective cohort study, we analyzed the maternal outcomes of 59 patients diagnosed with HELLP syndrome. The patients were divided into three groups according to their blood pressure levels during their stay in hospital. These three groups were compared in terms of patient characteristics and maternal outcomes. A combined endpoint for adverse maternal outcome was defined which included blood pressure and antihypertensive medication at discharge from hospital, severe postpartum anemia, and eclampsia.Women with hypertensive crises had an unfavorable outcome compared to women with lower blood pressure levels. Patients with higher blood pressure during pregnancy were more likely to be hypertensive at discharge and needed a combination of antihypertensive agents significantly more often. The risk of an adverse maternal outcome increased with the severity of hypertension. An increase in systolic blood pressure by 10 mmHg raised the risk of an adverse outcome by 74% (95% CI: 1.22–2.66).Hypertension not only plays an important role in preeclampsia but also affects the outcomes of patients with HELLP syndrome. These patients need to be identified quickly and treated accordingly as they are at risk of cardiovascular impairment. Patients should be followed up closely after delivery to reduce cardiovascular morbidity.