bluuebunny/crossref_metadata_2025_split huggingface dataset:
Domains, competences and learning outcomes for undergraduate education in periodontology
Authors: Figuero Elena , Gürsoy Mervi , Monnet‐Corti Virginie , Iniesta Margarita , Antezack Angeline , Kapferer‐Seebacher Ines , Graetz Christian , Vered Yuval , Stavropoulos Andreas , Wilensky Asaf , Eickholz Peter , Sanz Mariano 
Published: April 2024

AbstractAimThis review is intended to adapt the current conceptual framework in dental education based on four domains to propose a set of competences, learning outcomes and methods of teaching, learning and assessment for undergraduate education in periodontology.ReviewBased on the current framework of competences and learning outcomes recommended by the Association for Dental Education in Europe (ADEE), undergraduate education in periodontology has been updated using the classification and clinical practice guidelines for the diagnosis and treatment of periodontal and peri‐implant diseases.ConclusionsSpecific learning outcomes have been proposed within each competence area, that is in Domain I (n = 10), Domain II (n = 13), Domain III (n = 33) and Domain IV (n = 12). Teaching methods and learning activities based on the different dimensions of the cognitive process have been proposed. Additionally, 10 key learning outcomes have been proposed as exit outcomes, which implies their accomplishment within the final assessment of any graduating student.
Systematic review and meta‐analysis: Impact of depression on prognosis in inflammatory bowel disease
Authors: Ji Yuejin , Li Hongxiao , Dai Guoliang , Zhang Xu , Ju Wenzheng 
Published: April 2024

AbstractBackground and AimDepression is highly prevalent in patients with inflammatory bowel disease (IBD), which may affect the prognosis of IBD. This aimed to investigate the impact of depression on prognosis in IBD.MethodsA systematic literature search was performed in four databases (Medline, Embase, Web of Science, and PsycINFO) up to December 31, 2023. Studies were included if they investigated the impact of depression on prognosis in IBD. The primary outcome was flare in IBD, and secondary outcomes were hospitalization, readmission, emergency visits, surgery, and escalation of medical therapy. Relative risks (RRs) were utilized to estimate the risk in each of the above prognostic indicators.ResultsFourteen cohort and 10 case–control studies matched our entry criteria, comprising 630 408 patients with IBD. Twenty‐two of included studies were considered to have a low risk of bias. Depression was found to significantly increase the risk of flare (RR = 1.37, 95% CI 1.16–1.63), hospitalization (RR = 1.11, 95% CI 1.00–1.23), readmission (RR = 1.32, 95% CI 1.04–1.67), emergency visits (RR = 1.33, 95% CI 1.12–1.59), surgery (1.38, 95% CI 1.08–1.76), and escalation of medical therapy (RR = 1.38, 95% CI 1.13–1.69) in IBD. Of note, patients with depression in ulcerative colitis had significant differences in readmission (RR = 1.38, 95% CI 1.19–1.60) and escalation of medical therapy (RR = 1.78, 95% CI 1.55–2.04). Additionally, the association was observed in patients with Crohn's disease in terms of flare (RR = 1.47, 95% CI 1.08–2.01) and hospitalization (RR = 1.20, 95% CI 1.03–1.40).ConclusionsCurrent evidence suggested that depression could significantly increase the risk of poor prognosis worsening in patients with IBD. However, the association varied in IBD subtypes.
Assisted living residents with dementia: Disparities in mental health services pre and during COVID‐19
Authors: Temkin‐Greener Helena , Hua Yechu , Cai Shubing 
Published: April 2024

AbstractBackgroundLittle is known about mental health among Medicare beneficiaries with Alzheimer's disease or related dementias (ADRD) who reside in assisted living (AL) communities. The COVID‐19 pandemic may have curtailed ambulatory care access for these residents, but telehealth may have expanded it. We examined in‐person and telehealth use of ambulatory mental health visits among AL residents with ADRD, pre and during the COVID pandemic, focusing on race/ethnicity and Medicare/Medicaid dual status.MethodsA CY2018 cohort of AL residents with ADRD was identified. Outcome was any quarterly in‐person or telemedicine mental health visit based on national CY2019‐2020 Medicare claims. Key independent variables were individual race/ethnicity and dual status and the AL‐level proportion of dual residents. We estimated a linear probability model with random effects and robust standard errors. Quarterly indicators captured service use before and after the onset of the pandemic.ResultsThe study included 102,758 fee‐for‐service Medicare beneficiaries with ADRD in 13,400 ALs. One in five residents had any mental health visits prior to the COVID‐19 pandemic. Black residents, and those with dual Medicare/Medicaid eligibility, were significantly less likely to use mental health services prior to and during the pandemic. There were no significant differences in visits via telemedicine by race/ethnicity or individual dual status. Residents in AL communities with a higher proportion of duals had a lower likelihood of visits before and during the pandemic.Conclusions/ImplicationsMental health service use among AL residents with ADRD was low and declining prior to the pandemic. Telehealth allowed for mental health visits to continue during the pandemic, albeit at a lower level. Residents in ALs with a higher proportion of duals were less likely to have in‐person or telehealth visits. The results suggest that some ALs may find it difficult to assure mental health service provision to this vulnerable population.
Association of behavioural and social–communicative profiles in children with 16p11.2 copy number variants: a multi‐site study
Authors: Verbesselt J. , Walsh L. K. , Mitchel M. W. , Taylor C. M. , Finucane B. M. , Breckpot J. , Zink I. , Swillen A. 
Published: April 2024

AbstractBackgroundDespite the established knowledge that recurrent copy number variants (CNVs) at the 16p11.2 locus BP4–BP5 confer risk for behavioural and language difficulties, limited research has been conducted on the association between behavioural and social–communicative profiles. The current study aims to further delineate the prevalence, nature and severity of, and the association between, behavioural and social–communicative features of school‐aged children with 16p11.2 deletion syndrome (16p11.2DS) and 16p11.2 duplication (16p11.2Dup).MethodsA total of 68 individuals (n = 47 16p11.2DS and n = 21 16p11.2Dup) aged 6–17 years participated. Standardised intelligence tests were administered, and behavioural and social–communicative skills were assessed by standardised questionnaires. Scores of both groups were compared with population norms and across CNVs. The influence of confounding factors was investigated, and correlation analyses were performed.ResultsCompared with the normative sample, children with 16p11.2DS showed high rates of social responsiveness (67%) and communicative problems (69%), while approximately half (52%) of the patients displayed behavioural problems. Children with 16p11.2Dup demonstrated even higher rates of social–communicative problems (80–90%) with statistically significantly more externalising and overall behavioural challenges (89%). In both CNV groups, there was a strong positive correlation between behavioural and social–communicative skills.ConclusionsSchool‐aged children with 16p11.2 CNVs show high rates of behavioural, social responsiveness and communicative problems compared with the normative sample. These findings point to the high prevalence of autistic traits and diagnoses in these CNV populations. Moreover, there is a high comorbidity between behavioural and social–communicative problems. Patients with difficulties in both domains are vulnerable and need closer clinical follow‐up and care.
Staying on track – Keeping things running in a high‐end scientific imaging core facility
Authors: Renaud Oliver , Aulner Nathalie , Salles Audrey , Halidi Nadia , Brunstein Maia , Mallet Adeline , Aumayr Karin , Terjung Stefan , Levy Daniel , Lippens Saskia , Verbavatz Jean‐Marc , Heuser Thomas , Santarella‐Mellwig Rachel , Tinevez Jean‐Yves , Woller Tatiana , Botzki Alexander , Cawthorne Christopher ,   The Core4Life Consortium, Munck Sebastian 
Published: April 2024

AbstractModern life science research is a collaborative effort. Few research groups can single‐handedly support the necessary equipment, expertise and personnel needed for the ever‐expanding portfolio of technologies that are required across multiple disciplines in today's life science endeavours. Thus, research institutes are increasingly setting up scientific core facilities to provide access and specialised support for cutting‐edge technologies. Maintaining the momentum needed to carry out leading research while ensuring high‐quality daily operations is an ongoing challenge, regardless of the resources allocated to establish such facilities. Here, we outline and discuss the range of activities required to keep things running once a scientific imaging core facility has been established. These include managing a wide range of equipment and users, handling repairs and service contracts, planning for equipment upgrades, renewals, or decommissioning, and continuously upskilling while balancing innovation and consolidation.
Successful surgical management of a pyothorax in a Guinea baboon (Papio papio)
Authors: Sailler Anaïs , Laidebeure Sylvie , Lécu Alexis 
Published: April 2024

AbstractA 16‐year‐old male Guinea baboon (Papio papio) was evaluated for weakness and focal wet fur of 1‐week duration. A pyothorax caused by Streptococcus anginosus was diagnosed. A surgical approach was chosen, combined with a systemic antibiotic therapy. Medical imaging and C‐reactive protein follow‐up revealed the resolution of the pyothorax.
Early transfusion patterns improve the Molecular International Prognostic Scoring System (IPSS‐M) prediction in myelodysplastic syndromes
Authors: Creignou Maria , Bernard Elsa , Gasparini Alessandro , Tranberg Anna , Todisco Gabriele , Moura Pedro Luis , Ejerblad Elisabeth , Nilsson Lars , Garelius Hege , Antunovic Petar , Lorenz Fryderyk , Rasmussen Bengt , Walldin Gunilla , Mortera‐Blanco Teresa , Jansson Monika , Tobiasson Magnus , Elena Chiara , Ferrari Jacqueline , Gallì Anna , Pozzi Sara , Malcovati Luca , Edgren Gustaf , Crowther Michael J. , Jädersten Martin , Papaemmanuil Elli , Hellström‐Lindberg Eva 
Published: April 2024

AbstractBackgroundThe Molecular International Prognostic Scoring System (IPSS‐M) is the new gold standard for diagnostic outcome prediction in patients with myelodysplastic syndromes (MDS). This study was designed to assess the additive prognostic impact of dynamic transfusion parameters during early follow‐up.MethodsWe retrieved complete transfusion data from 677 adult Swedish MDS patients included in the IPSS‐M cohort. Time‐dependent erythrocyte transfusion dependency (E‐TD) was added to IPSS‐M features and analyzed regarding overall survival and leukemic transformation (acute myeloid leukemia). A multistate Markov model was applied to assess the prognostic value of early changes in transfusion patterns.ResultsSpecific clinical and genetic features were predicted for diagnostic and time‐dependent transfusion patterns. Importantly, transfusion state both at diagnosis and within the first year strongly predicts outcomes in both lower (LR) and higher‐risk (HR) MDSs. In multivariable analysis, 8‐month landmark E‐TD predicted shorter survival independently of IPSS‐M (p < 0.001). A predictive model based on IPSS‐M and 8‐month landmark E‐TD performed significantly better than a model including only IPSS‐M. Similar trends were observed in an independent validation cohort (n = 218). Early transfusion patterns impacted both future transfusion requirements and outcomes in a multistate Markov model.ConclusionThe transfusion requirement is a robust and available clinical parameter incorporating the effects of first‐line management. In MDS, it provides dynamic risk information independently of diagnostic IPSS‐M and, in particular, clinical guidance to LR MDS patients eligible for potentially curative therapeutic intervention.
Black mothers' ethnic–racial socialization one year after highly publicized anti‐Black murders during the pandemic
Authors: Coates Erica E. , Moore Carrington , de Heer Rebecca , Brumley Calyn , Prudhomme Arielle , Edwards Lauren , Curtis Latisha 
Published: April 2024

AbstractAlthough research on ethnic–racial socialization is well established, limited studies have examined the influence of specific, highly publicized anti‐Black murders. We assessed Black mothers' (N = 12, mean age = 37.45) concerns and ethnic–racial socialization with adolescents aged 11–18 years old approximately 1 year following the murders of George Floyd and other unarmed Black people. Researchers generated the following themes using reflexive thematic analysis: protecting adolescents from physical harm; protecting adolescents from psychological harm; parents' emotional distress; and parents' lack of confidence in their ethnic–racial socialization practices. Black mothers exhibit exceptional amounts of strength and courage as they navigate pervasive physical and psychological threats to their adolescents while experiencing worry and low confidence in their ability to socialize their adolescents about anti‐Black racism.
Development of a hard cider flavor wheel using free word sorting and multivariate statistical techniques
Authors: Calvert Martha D. , Neill Clinton L. , Ac‐Pangan Marlon F. , Stewart Amanda C. , Lahne Jacob 
Published: April 2024

AbstractFlavor wheels are visual tools built from standardized sensory lexicons that are used in many different industries to improve communication, marketing, and quality discrimination among products. To date, flavor wheels have been developed for spices, coffee, wine, beer, and many other foods and beverages—yet no flavor wheel has been constructed for hard cider. While there is no single established method for constructed flavor wheels, most approaches are based on sensory descriptive analysis (DA) and free word sorting activities that investigate the semantic similarity and dissimilarity of descriptive terms. This research study utilized multiple DA studies for the generation of a sensory lexicon, followed by independent word sorting tasks with cider industry professionals (N = 40) and untrained consumers (N = 58) to establish two flavor wheels that are broadly understandable to a variety of industry stakeholders. Based on the results of DISTATIS and additive tree partitioning, this research showcases a workflow for developing and refining flavor wheels that incorporate both stakeholder and researcher input and can be built upon by other analysts.Practical ApplicationsThis research demonstrates an accessible methodology for developing flavor wheels that incorporates input from diverse parties and considers the semantic associations of terms used by cider consumers and industry professionals. The proposed methodology is a useful framework for other sensory scientists seeking to efficiently develop flavor wheels for multiple audiences. As a demonstration, this research also delivers two flavor wheels—one that highlights discrepancies in how industry consumers and producers semantically understand sensory experiences compared to trained sensory personnel, and a second wheel that showcases how hard cider can more objectively be described. Together, these flavor wheels are tools for improving sensory communication, education, and marketing in the US hard cider industry.
Epidemiology and assessment of Hepatitis B positive children in Western Australia
Authors: Bartley Hannah Elizabeth , Turner Emma Kate Lefroy , Ford Timothy John , Cherian Sarah 
Published: April 2024

AimTo describe the characteristics of patients with chronic hepatitis B (CHB) presenting to a tertiary paediatric hospital in Perth, Western Australia. Review of implementation of previous follow‐up recommendations for the cohort was also undertaken.MethodA retrospective data analysis of all individuals aged between 0 and 17 years presenting to the tertiary children's hospital who were hepatitis B surface antigen (HBsAg) positive over 8 years (2013–2020). Demographic features, clinical progress and follow up are described, including proportion transferred to adult services.ResultsSeventy‐four patients were identified to have CHB; mean age at diagnosis 11 years; standard deviation 4 years; 41 (55%) male. Cultural and ethnolinguistic diversity was high; 74% (n = 55) were from refugee‐like backgrounds. Many did not demonstrate English proficiency (23/40; 75%) and 7 (10%) Australian born including 4 patients who were Aboriginal. Most patients (58%) with CHB were in the hepatitis B e antigen‐positive chronic infection phase with no intervention provided. Seventeen children had undergone liver ultrasonography and one underwent liver biopsy; none received antiviral treatment. Follow up was concerning; 28 (38%) had at least one clinic non‐attendance, 24 (32%) lost to follow‐up and interpreter utilisation was poorly documented. Thirty‐nine (53%) were transferred to adult services with only 56% attending follow‐up.ConclusionCHB burden is higher in those from culturally and ethnolinguistically diverse backgrounds. There is a significant loss to follow‐up and suboptimal transfer to adult services. Improved recall, education and referral processes are necessary to overcome language, socioeconomic and cultural barriers. Although childhood complications are infrequent, longitudinal monitoring is crucial to prevent long‐term complications and adult morbidity.
Disease spectrum of torticollis in children and diagnostic flowchart: A retrospective, single‐centre study
Authors: Jianqiang Ma , Haitian Li , Xiaohu Fu , LV Zhongli , Xiaohong Mu 
Published: April 2024

AimTo describe the disease spectrum of torticollis in Chinese children and to improve its diagnostic flowchart.MethodsA retrospective analysis was conducted at the Rehabilitation Department of Beijing Children’s Hospital from 2017 to 2021. Patients were diagnosed and referred based on a diagnostic flowchart of torticollis. Detailed patient data were collected from the outpatient electronic medical record system.ResultsA total of 2047 patients met the inclusion criteria. The top five conditions were congenital muscular torticollis (CMT) (76.6%), cerebral palsy (5.1%), ocular torticollis (4.7%), brachial plexus injury (1.9%) and atlantoaxial rotary subluxation (1.3%). CMT was most common in 0–2 year olds, cerebral palsy in 3–5 year olds, and atlantoaxial rotary subluxation in 7–12 year olds. The top five referral departments were orthopaedics, ophthalmology, otolaryngology, head and neck surgery, neurology and neurosurgery.ConclusionsThe disease spectrum of torticollis in children and the diagnostic flowchart provide important references for diagnosing torticollis, which necessitates multidisciplinary collaboration.
Development of the Multidimensional Workaholism Scale (MWS) Japanese Edition and Examination of its Convergent, Discriminant, and Incremental Validity
Authors: Eslami Armaghan , Kanai Atsuko , Matsumoto Miyuki 
Published: April 2024

AbstractThis study aimed to translate and validate the Multidimensional Workaholism Scale (MWS) for the Japanese population in two divided studies. The MWS has four dimensions—motivational, emotional, cognitive, and behavioral—with a correlated four‐factor model. In Study 1, we translated the MWS into Japanese using the back‐translation method. Next, 200 participants recruited by a research company answered the Japanese version of the MWS. An exploratory factor analysis of the collected data indicated four factors that were in line with the original scale. In the second survey, 316 different participants were recruited using the same method as in Study 1, and they responded to the MWS, WorkBat, Dutch Work Addiction Scale, work engagement, perfectionism, work–family conflict, and negative affect measures. At first, we tested different factorial models of the MWS through the confirmatory factor analysis and correlated the four‐factor model that indicated the best model fit. Next, the discriminant, convergent, and incremental validity of the MWS were tested in Study 2. In general, the Japanese version of the MWS has good validity and reliability. Finally, some of the results, implications, and limitations of this study are discussed.
Molecular phylogeny and spatio‐temporal diversification of the Millettioid/Phaseoloid clade (Fabaceae: Papilionoideae)
Authors: Oyebanji Oyetola , Stull Gregory W. , Zhang Rong , Rahaingoson Fabien R. , Li De‐Zhu , Yi Ting‐Shuang 
Published: April 2024

AbstractThe Millettioid/Phaseoloid (or the Millettioid) clade is a major lineage of the subfamily Papilionoideae (Fabaceae) that is poorly understood in terms of its diversification and biogeographic history. To fill this gap, we generated a time‐calibrated phylogeny for 749 species representing c. 80% of the genera of this clade using nrDNA ITS, plastid matK, and plastome sequence (including 38 newly sequenced plastomes). Using this phylogenetic framework, we explored the clade's temporal diversification and reconstructed its ancestral areas and dispersal events. Our phylogenetic analyses support the monophyly of the Millettioid/Phaseoloid clade and four of its tribal lineages (Abreae, Desmodieae, Indigofereae, and Psoraleeae), while two tribal lineages sensu lato millettioids and phaseoloids are polyphyletic. The fossil‐calibrated dating analysis showed a nearly simultaneous divergence between the stem node (c. 62 Ma) and the crown node (c. 61 Ma) of the Millettioid/Phaseoloid clade in the Paleocene. The biogeographic analysis suggested that the clade originated in Africa and dispersed to Asia, Europe, Australia, and the Americas at different periods in the Cenozoic. We found evidence for shifts in diversification rates across the phylogeny of the Millettioid/Phaseoloid clade throughout the Cenozoic, with a rapid increase in net diversification rates since c. 10 Ma. Possible explanations for the present‐day species richness and distribution of the Millettioid/Phaseoloid clade include boreotropical migration, frequent intra‐ and intercontinental long‐distance dispersals throughout the Cenozoic, and elevated speciation rates following the Mid‐Miocene Climatic Optimum. Together, these results provide novel insights into major diversification patterns of the Millettioid/Phaseoloid clade, setting the stage for future evolutionary research on this important legume clade.