bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent advancements in the biosynthetic mechanisms for polyketide‐derived mycotoxins
Authors: Huffman Justin , Gerber Ryan , Du Liangcheng 
Published: June 2010

AbstractPolyketides (PKs) are a large group of natural products produced by microorganisms and plants. They are biopolymers of acetate and other short carboxylates and are biosynthesized by multifunctional enzymes called polyketide synthases (PKSs). This review discusses the biosynthesis of four toxic PK, aflatoxins, fumonisins, ochratoxins (OTs), and zearalenone. These metabolites are structurally diverse and differ in their mechanisms of toxicity. However, they are all of concern in food safety and agriculture because of their toxic properties and their frequent accumulation in crops used for food and feed. The focus is on the recent advancements in the understanding of the molecular mechanisms for the biosynthesis of these mycotoxins. Several of the mycotoxin PKSs have been genetically and biochemically studied while other PKSs remain to be investigated. Multiple post‐PKS modifications are often required for the maturation of the mycotoxins. Many of these modification steps for aflatoxins and fumonisins are well established while the post‐PKS modifications for zearalenone and OTs remain to be biochemically characterized. More efforts are needed to completely illustrate the biosynthetic mechanisms for this important group of PKs. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 764–776, 2010.
Heterologous expression of the biosynthetic gene clusters of coumermycin A1, clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains
Authors: Flinspach Katrin , Westrich Lucia , Kaysser Leonard , Siebenberg Stefanie , Gomez‐Escribano Juan Pablo , Bibb Mervyn , Gust Bertolt , Heide Lutz 
Published: June 2010

AbstractThe biosynthetic gene clusters of the aminocoumarin antibiotics clorobiocin and coumermycin A1 and of the liponucleoside antibiotic caprazamycin were stably integrated into the genomes of different host strains derived from Streptomyces coelicolor A3(2). For the heterologous expression of clorobiocin derivatives in a chemically defined medium, inclusion of 0.6% of the siloxylated ethylene oxide/propylene oxide copolymer Q2‐5247 into the growth medium proved to result in a 4.8‐fold increase of productivity. Presumably, this copolymer acts as an oxygen carrier. The additional inclusion of cobalt chloride (0.2–2 mg l−1) dramatically increased the percentage of the desired compound clorobiocin within the total produced clorobiocin derivatives. This is very likely due to a stimulation of a cobalamin‐dependent methylation reaction catalyzed by the enzyme CloN6 of clorobiocin biosynthesis. All three investigated host strains (S. coelicolor M512, M1146 and M1154) gave similar production rates of total clorobiocin derivatives (on average, 158 mg l−1 in the presence of 0.6% Q2‐5247 and 0.2 mg l−1 CoCl2). In contrast, heterologous production of caprazamycin derivatives was optimal in strain M1154 (amounts of 152 mg l−1 on average). © 2010 Wiley Periodicals, Inc. Biopolymers 93: 823–832, 2010.
Probing the active site of MIO‐dependent aminomutases, key catalysts in the biosynthesis of β‐amino acids incorporated in secondary metabolites
Authors: Cooke Heather A. , Bruner Steven D. 
Published: June 2010

AbstractThe tyrosine aminomutase SgTAM produces (S)‐ß‐tyrosine from L‐tyrosine in the biosynthesis of the enediyne antitumor antibiotic C‐1027. This conversion is promoted by the methylideneimidazole‐5‐one (MIO) prosthetic group. MIO was first identified in the homologous family of ammonia lyases, which deaminate aromatic amino acids to form α,ß‐unsaturated carboxylates. Studies of substrate specificity have been described for lyases but there have been limited reports in altering the substrate specificity of aminomutases. Furthermore, it remains unclear as to what structural properties are responsible for catalyzing the presumed readdition of the amino group into the α,ß‐unsaturated intermediates to form ß‐amino acids. Attempts to elucidate specificity and mechanistic determinants of SgTAM have also proved to be difficult as it is recalcitrant to perturbations to the active site via mutagenesis. An X‐ray cocrystal structure of the SgTAM mutant of the catalytic base with L‐tyrosine verified important substrate binding residues as well as the enzymatic base. Further mutagenesis revealed that removal of these crucial interactions renders the enzyme inactive. Proposed structural determinants for mutase activity probed via mutagenesis, time‐point assays and X‐ray crystallography revealed a complicated role for these residues in maintaining key quaternary structure properties that aid in catalysis. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 802–810, 2010.
Heparin or enoxaparin anticoagulation for primary percutaneous coronary intervention
Authors: Brieger David , Collet Jean‐Philippe , Silvain Johanne , Landivier Antoine , Barthélémy Olivier , Beygui Farzin , Bellemain‐Appaix Anne , Mercadier Anne , Choussat Remi , Vignolles Nicolas , Costagliola Dominique , Montalescot Gilles 
Published: June 2010

AbstractObjectives: The aim of this study was to compare efficacy and safety outcomes among patients receiving enoxaparin or unfractionated heparin (UFH) while undergoing percutaneous coronary intervention (PCI) for ST‐segment elevation myocardial infarction (STEMI). Background: Primary PCI (pPCI) for ST elevation has traditionally been supported by UFH. The low molecular weight heparin enoxaparin may provide better outcomes when used for pPCI. Methods: Consecutive eligible patients (580) undergoing pPCI enrolled in the prospective electronic Pitié‐Salpêtrière registry of ischemic coronary syndromes (e‐PARIS) registry were grouped according to whether they received UFH or enoxaparin as the sole anticoagulant. Logistic regression modeling, propensity‐weighted adjustment, and sensitivity analyses were used to evaluate efficacy and safety endpoints for enoxaparin vs. UFH. Results: Enoxaparin was administered to 346 patients and UFH to 234 without ACT or anti‐Xa guided dose adjustment. PCI was performed through the radial artery in 90%, with frequent (75%) use of GPIIb/IIIa antagonists. Patients receiving enoxaparin were more likely to be therapeutically anticoagulated during the procedure (68% vs. 50%, P < 0.0001) and were less likely to experience death or recurrent myocardial infarction (MI) in hospital (adjusted OR 0.28 95% CI (0.12–0.68) or by 30 days (adjusted OR 0.35 95% CI 0.16–0.81). All cause mortality was also reduced in hospital (adjusted OR 0.32, 95% CI (0.12–0.85) and to 30 days (adjusted OR 0.40 95% CI 0.17–0.99). Other ischemic endpoints were similarly reduced with enoxaparin. Thrombolysis in myocardial infarction (TIMI) major bleeding events were numerically fewer among patients receiving enoxaparin (1.2% vs. 2.6%, P = 0.2). Conclusions: In patients with STEMI presenting for PCI, enoxaparin was associated with a reduction in all ischemic complications, more frequent therapeutic anticoagulation, and no increase in major bleeding when compared against unfractionated heparin. © 2010 Wiley‐Liss, Inc.
Retrograde transcatheter closure of ventricular septal defects in children using the Amplatzer Duct Occluder II
Authors: Koneti Nageswara Rao , Penumatsa Raghava Raju , Kanchi Vasudevan , Arramraj Srinivas Kumar , S. Jaishankar , Bhupathiraju Somaraju 
Published: June 2010

AbstractObjectives: To describe the technique and results of transcatheter closure of ventricular septal defects (VSDs) by a modified retrograde transarterial approach using the new Amplatzer Duct Occluder II (ADO II). Background: Transcatheter device closure of ventricular septal defects (VSDs) by antegrade method is well established, but a challenging procedure. We describe a retrograde technique that obviates the need for arteriovenous looping. Material and Methods: This is a prospective study from a single center. Between April 2009 and February 2010 13 children were identified for closure of various types of perimembranous and muscular VSDs using the ADO II device. All had met the criteria for surgical closure. Following left ventricular angiogram two were excluded as technically nonfeasible. The median age was 48 months (range 15–78). The median weight was 14 kg (range 7.5–20). The device was successfully deployed in the 11 selected children by the method described. The follow‐up evaluation included chest roentgenogram, ECG, and echocardiogram on day 1, at 6 weeks, at 3, 6, and 12 months. Results: The immediate and follow up complete closure rates were 73 and 82%, respectively. The median fluoroscopic time was 14 min (range 8.2–45). There were no procedure related complications. All patients were doing well at median follow up of 10 months; none showing any conduction abnormality. Conclusion: Transcatheter retrograde device closure of selected cases of Ventricular Septal Defects using the Amplatzer Duct Occluder II is simple and appears safe in the short term and can be completed within a short fluoroscopic time.© 2010 Wiley‐Liss, Inc.
Effects of aspiration thrombectomy on necrosis size and ejection fraction after transradial percutaneous coronary intervention in acute ST‐elevation myocardial infarction
Authors: Bertrand Olivier F. , Larose Éric , Costerousse Olivier , Mongrain Rosaire , Rodés‐Cabau Josep , Déry Jean‐Pierre , Nguyen Can M. , Barbeau Gérald , Gleeton Onil , Proulx Guy , De Larochellière Robert , Noël Bernard , Roy Louis 
Published: June 2010

AbstractBackground: The use of routine aspiration thrombectomy in primary percutaneous coronary intervention (PCI) remains controversial. Methods: Patients in the EArly Discharge after Transradial Stenting of CoronarY Arteries in Acute Myocardial Infarction (n = 105) study were treated with aspirin, clopidogrel, and abciximab within 6 hr of symptoms onset. Operators were allowed to use 6 Fr Export aspiration catheter at their discretion. In this observational analysis, we compared acute and late results in patients treated with and without thrombectomy using cardiac biomarkers, angiographic, cardiovascular magnetic resonance (CMR), and clinical parameters. Results. Patients in the thrombectomy group (n = 44) had longer symptoms to balloon time (196 ± 86 min vs. 164 ± 62, P = 0.039) and higher incidence of preprocedural TIMI flow grade 0 or 1 (84% vs. 64%, P = 0.028). Following PCI, both groups had similar incidence of TIMI flow grade 3 (93 vs. 92%, P = 0.73) and myocardial blush grade 2 or 3 (80 vs. 77%, P = 0.86), respectively. Patients in thrombectomy group had significantly higher post‐PCI maximum values of creatine kinase‐MB (P = 0.0007) and troponin T (P = 0.0010). Accordingly, post‐PCI myocardial necrosis by CMR was higher (P = 0.0030) in patients in the thrombectomy group. At 6‐month follow‐up, necrosis size remained higher (20.7% ± 13.3% vs. 13.5% ± 11.1%, P = 0.012) in the thrombectomy group. Ejection fraction at 6 months was 65% ± 9% in patients in thrombectomy group compared to 70% ± 11% in patients without (P = 0.070). Results were not affected by initial TIMI flow or symptoms to balloon time. Clinical events remained comparable in both groups at 12 months follow‐up. Conclusion: In patients with ST‐segment elevation myocardial infarction presenting within 6 hr of symptoms and undergoing primary angioplasty with maximal antiplatelet therapy, acute and late results did not suggest significant benefit for additional aspiration thrombectomy, irrespective of initial TIMI flow or total ischemic time. © 2010 Wiley‐Liss, Inc.
ChemInform Abstract: Combination of Ion Exchange and Freeze Drying as a Synthetic Route to New Oxoferrates(VI) M2FeO4 with M: Li, Na, N(CH3)4, N(CH3)3Bzl, N(CH3)3Ph.
Authors: MALCHUS M. , JANSEN M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Disodium Zinc Pyrophosphate and Disodium (Europium) Zinc Pyrophosphate.
Authors: ERRAGH F. , BOUKHARI A. , SADEL A. , HOLT E. M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: KAg5S3.
Authors: EMIRDAG M. , SCHIMEK G. L. , KOLIS J. W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pentaamminenitrocobalt(III) Dichloride at Pressure of 0.24, 0.52, 1.25, 1.91 and 3.38 GPa.
Authors: BOLDYREVA E. V. , AHSBAHS H. , NAUMOV D. YU. , KUTOGLU A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: (NH4)Zn2(PO4)(HPO4).
Authors: BIRCSAK Z. , HARRISON W. T. A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrosynthesis of Sodium Hydrosulfite. Part 2. The Effect of Cathode Material.
Authors: Ding Youzhen , Scott Leonard L. , Stalder Sloane M. , Kohl Paul A. , Winnick Jack , Bottomley Lawrence A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aluminum and Aluminum Alloy Dissolution in Concentrated Phosphoric Acid.
Authors: Vidal Roberto , West Alan C. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Understanding the Nature of Low‐Potential Li Uptake into High Volumetric Capacity Molybdenum Oxides.
Authors: Leroux F. , Goward G. R. , Power W. P. , Nazar L. F. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bipyridine Building Blocks for Self‐Organization Systems: First Complete NMR‐Spectroscopic Investigation of 6,6′‐Disubstituted 2,2′‐Bipyridines Obtained via N‐Oxidation Route and Related Reactions.
Authors: SCHUBERT U. S. , NEWKOME G. R. , GOELDEL A. , PEMP A. , KERSTEN J. L. , EISENBACH C. D. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Analysis of Natural Abundance Deuterium NMR Spectra of Enantiomers in Chiral Liquid Crystals via 2D Auto‐correlation Experiments.
Authors: MERLET D. , ANCIAN B. , SMADJA W. , COURTIEU J. , LESOT P. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Barium Cobalt Phosphate, BaCo2(PO4)2.
Authors: Bircsak Zsolt , Harrison William T. A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structures, Vibrational Spectra and Normal Coordinate Analysis of cis‐[ReCl4X2]2‐, X: NCS, NCSe.
Authors: Homolya L. , Struess S. , Preetz W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: La0.9Sr0.1Ga0.8Mn0.2 O2.85: A New Oxide Ion Conductor.
Authors: Thangadurai V. , Shukla A. K. , Gopalakrishnan J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical—Hydrothermal Synthesis and Structural Characterization of Zn2(OH)VO4.
Authors: Wang Xiqu , Liu Lumei , Jacobson Allan J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: On Thallium(I)‐oxochloromolybdates: Synthesis and Crystal Structures of Tl[MoOCl4(NCCH3)], Tl[Mo2O2Cl7], and Tl2[Mo4O4Cl14] and the Structure of Tl2[MoCl6].
Authors: Beck J. , Hengstmann M. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular‐Recognition‐Directed Self‐Assembly of Pleated Sheets from 2‐Aminopyrimidine Hydrogen‐Bonding Motifs.
Authors: KRISCHE M. J. , LEHN J.‐M. , KYRITSAKAS N. , FISCHER J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Recognition of Pyranosides by a Family of Trimeric, 1,1′‐Binaphthalene‐Derived Cyclophane Receptors.
Authors: BAEHR A. , DROZ A. S. , PUENTENER M. , NEIDLEIN U. , ANDERSON S. , SEILER P. , DIEDERICH F. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Sensing of Mercury over Cadmium and Lead Cations by the Redox‐Active Polyazacycloalkane Ligand 1,1′′:1′,1′′′‐Bis[ethane‐1,2‐diylbis(iminomethylene)]bis[ferrocene].
Authors: LLORIS J. M. , BENITO A. , MARTINEZ‐MANEZ R. , PADILLA‐TOSTA M. E. , PARDO T. , SOTO J. , TENDERO M. J. L. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Effects of the Substituent Groups at the 4‐ and 7‐Positions on the Fluorescence Characteristics of Benzofurazan Compounds.
Authors: UCHIYAMA S. , SANTA T. , FUKUSHIMA T. , HOMMA H. , IMAI K. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phenols, Acetylenes, and Sesquiterpene Lactones from Inulanthera nuda.
Authors: GAFNER S. , WOLFENDER J.‐L. , HOSTETTMANN K. , STOECKLI‐EVANS H. , MAVI S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Double Stereocontrol in α‐Alkylation of Chiral Lithium Dienolates Generated from (E)‐α,β‐Olefinic Amides and Esters.
Authors: Tomooka Katsuhiko , Nagasawa Atsushi , Nakai Takeshi 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereochemistry and Fate of Hydrogen Atoms in the Diol‐Dehydratase‐Catalyzed Dehydration of meso‐Butane‐2,3‐diol.
Authors: MANITTO P. , SPERANZA G. , FONTANA G. , GALLI A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Impurity Annihilation: A Strategy for Solution Phase Combinatorial Chemistry with Minimal Purification.
Authors: BARRETT A. G. M. , SMITH M. L. , ZECRI F. J. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Radical and Palladium‐Mediated Cyclizations of ortho‐Iodo Benzyl Enamines: A Scope and Limitation Study.
Authors: BERTEINA S. , DE MESMAEKER A. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.