bluuebunny/crossref_metadata_2025_split huggingface dataset:
Catalytic ozonation of reverse osmosis membrane concentrates by catalytic ozonation: Properties and mechanisms
Authors: Sun Wenquan , Cheng Yueqian , Xiao Zhiqiang , Zhou Jun , Shah Kinjal J. , Sun Yongjun 
Published: June 2024

AbstractNi‐Mn@KL ozone catalyst was prepared for the efficient treatment of reverse osmosis membrane concentrates. The working conditions and reaction mechanism of the ozone‐catalyzed oxidation by Ni‐Mn@KL were systematically studied. Then, a comprehensive CRITIC weighting–coupling coordination evaluation model was established. Ni‐Mn@KL was characterized by scanning electron microscopy, BET, X‐ray diffraction, X‐ray photoelectron spectroscopy, energy‐dispersive spectrometry, and X‐ray fluorescence spectrometry and found to have large specific surface area and homogeneous surface dispersion of striped particles. Under the optimum working conditions with an initial pH of 7.9 (raw water), a reaction height‐to‐diameter ratio of 10:1, an ozone‐aeration intensity of 0.3 L/min, and a catalyst filling rate of 10%, the maximum COD removal rate was 60.5%. Free‐radical quenching experiments showed that OH oxidation played a dominant role in the Ni‐Mn@KL‐catalyzed ozone‐oxidation system, and the reaction system conformed to the second‐order reaction kinetics law. Ni‐Mn@KL catalysts were further confirmed to have good catalytic performance and mechanical performance after repeated utilization.Practitioner Points
Ni‐Mn@KL catalyst can achieve effective treatment of RO film concentrated liquid.
High COD removal rate of RO membrane concentrated liquid was obtained at low cost.
Ni‐Mn@KL catalyst promotes ozone decomposition to produce ·OH and O2−· oxidized organic matter.
The Ni‐Mn@KL catalyst can maintain good stability after repeated use.
A CRITIC weight–coupling coordination model was established to evaluate the catalytic ozonation.
Decided Return and Reintegration in a Post-Conflict Society
Authors: Ibričević Aida 
Published: June 2024

AbstractThe people my study attempts to understand are part of a small cohort in absolute terms, and particularly small relative to the staggering numbers of people either leaving or trying to leave Bosnia and Herzegovina. Their return is voluntary because each study participant could stay in the host state, as most of them have also attained full citizenship status. There was also no direct political, economic, social, or family pressure for them to return, and they were not part of an assisted return program. They are of full working age, still in the process of building a retirement nest egg and thus, the decision to return to Bosnia and Herzegovina entailed a considerable amount of financial risk. The circumstances of their departure from BiH were, most times, violent and traumatic, while their years of life as a refugee in the host state were filled with other kinds of struggle. However, at the time of their return, they are no longer refugees. After gaining citizenship of the host state and managing to re-build their shattered lives abroad, they decide to come back. This chapter attempts to understand why and what happens to them later on?
The Emotional Dimension of BiH Citizenship
Authors: Ibričević Aida 
Published: June 2024

AbstractThe argument presented in my study is that the motivation to return to a post-conflict society, like Bosnia and Herzegovina, given a viable alternative of livelihood and successful integration abroad is primarily emotional. This premise makes the returnees particularly sensitive to the emotional experience of citizenship and therefore, their understanding of “citizenship as feeling” is expected to be particularly pronounced, nuanced and diversified. In addition, most of the participants are dual citizens, and as such, they are in a position to compare their emotional experiences, or lack thereof, of both home and host state citizenships. Emotional citizenship relies heavily on citizenship as practice (Wood, 2013), that is on the daily experience of citizenship (Nyers, 2007), so for analytical purposes, the concept of “emotional citizenship” is defined as the area of intersection between the daily experience of citizenship and an emotional response. Some examples of the daily experiences of citizenship discussed with the returnees include remembering events from BiH’s recent past and the 1992–95 war; experiencing commemorations of genocide and war atrocities, seeing the BiH flag or hearing the BiH national anthem; using the BiH passport at border controls; attempting to resolve an administrative issue; voting; or paying taxes to the BiH government. The overarching research questions this chapter aims to answer are: What understanding do return migrants have of the ‘emotional dimension of BiH citizenship’? Which specific emotions do they associate with citizenship?
Connecting the Dots: Conceptual Model
Authors: Ibričević Aida 
Published: June 2024

AbstractAfter presenting a wealth of empirical material to illustrate the complexity of observed social reality, which often includes conflicting and puzzling elements, the question emerges: is there some unifying pattern that could produce an overall explanation, re-storying the data “into a framework that makes sense” (Creswell, 2007, p.56)? This chapter aspires to provide the “intellectual satisfaction” (Blaikie, 2010, p. 71), promised by qualitative research by presenting a lower-level abstraction conceptual model as a response to the main theoretical problem. On a conceptual level, my study tackles the creation of a nexus between voluntary return migration, citizenship, home, belonging and a set of specific ‘political’ emotions. When laying out the foundation for my contribution, I defined the theoretical problem; reviewed the existing literature(s) to examine how the relevant concepts have been explored previously; and I identified the research gaps. The research design of my study operates within the interpretivist paradigm, which requires the researcher not only to observe social reality, but to understand and interpret it. This chapter aims to deliver an empathetic understanding, the Weberian notion ofVerstehen, by offering a solution to the central theoretical problem.
LUZP1 regulates the maturation of contractile actomyosin bundles
Authors: Wang Liang , Tsang Hoi Ying , Yan Ziyi , Tojkander Sari , Ciuba Katarzyna , Kogan Konstantin , Liu Xiaonan , Zhao Hongxia 
Published: June 2024

AbstractContractile actomyosin bundles play crucial roles in various physiological processes, including cell migration, morphogenesis, and muscle contraction. The intricate assembly of actomyosin bundles involves the precise alignment and fusion of myosin II filaments, yet the underlying mechanisms and factors involved in these processes remain elusive. Our study reveals that LUZP1 plays a central role in orchestrating the maturation of thick actomyosin bundles. Loss of LUZP1 caused abnormal cell morphogenesis, migration, and the ability to exert forces on the environment. Importantly, knockout of LUZP1 results in significant defects in the concatenation and persistent association of myosin II filaments, severely impairing the assembly of myosin II stacks. The disruption of these processes in LUZP1 knockout cells provides mechanistic insights into the defective assembly of thick ventral stress fibers and the associated cellular contractility abnormalities. Overall, these results significantly contribute to our understanding of the molecular mechanism involved in actomyosin bundle formation and highlight the essential role of LUZP1 in this process.
Schnelle Hilfen für Betroffene von akuter Gewalt – aktuelle Versorgung in Traumaambulanzen in Deutschland
Authors: Giesmann Marc , Flatten-Whitehead Isabella , Specht Lina , Fegert Jörg M. , Schellong Julia , Rassenhofer Miriam , Schäfer Ingo 
Published: June 2024

Zusammenfassung
Hintergrund
Hilfen nach akuter Gewalt wurden bislang durch das Opferentschädigungsgesetz (OEG) geregelt. Zu Beginn des laufenden Jahres wurde es durch das Sozialgesetzbuch XIV (SGB XIV) abgelöst. Durch das SGB XIV werden neue Gruppen von Leistungsberechtigten definiert, Traumaambulanzen müssen flächendeckend vorgehalten werden und es wurden verbindliche Kriterien für die Qualität der Versorgung festgelegt. Die vorliegende Untersuchung hatte zum Ziel, den aktuellen Stand der Versorgung in Traumaambulanzen nach den Vorgaben des neuen SGB XIV abzubilden. In Bezug auf neue Leistungsberechtigte wurde exemplarisch der Stand der Angebote für Betroffene von Menschenhandel erfasst.

Methodik
Ambulanzen, die Schnelle Hilfe nach dem OEG bzw. SGB XIV anbieten, wurden zu strukturellen und inhaltlichen Aspekten ihrer Arbeit befragt. Dabei kam ein Online-Survey zum Einsatz, der aus 10 thematischen Modulen bestand. Es konnten Daten von insgesamt N = 110 Ambulanzen erhalten werden (Rücklaufquote 50 %).

Ergebnisse
Die teilnehmenden Ambulanzen berichteten eine breite Spannweite in Bezug auf die Anzahl der dort Beschäftigten und die Anzahl der Ratsuchenden. Bei einem Teil der Ambulanzen zeigten sich Defizite in Bezug auf strukturelle Aspekte wie die Wartezeit bis zum Erstgespräch und spezifische traumatherapeutische Fortbildungen beim Personal. In Bezug auf den Umgang mit Betroffenen von Menschenhandel bestand beim überwiegenden Teil der Ambulanzen Unsicherheit.

Diskussion
Traumaambulanzen scheinen ihre Zielpopulation zu erreichen und angemessene Angebote zu deren Versorgung vorzuhalten. Allerdings weist ein bedeutsamer Teil der Ambulanzen Nachbesserungsbedarf auf, um die Qualitätskriterien des SGB XIV zu erfüllen und neue Gruppen von Leistungsberechtigten angemessen zu versorgen.
New insights into aflatoxin B1 mechanistic toxicology in cattle liver: an integrated approach using molecular docking and biological evaluation in CYP1A1 and CYP3A74 knockout BFH12 cell lines
Authors: Iori Silvia , Lahtela-Kakkonen Maija , D’Onofrio Caterina , Maietti Federica , Mucignat Greta , Bardhi Anisa , Barbarossa Andrea , Zaghini Anna , Pauletto Marianna , Dacasto Mauro , Giantin Mery 
Published: June 2024

AbstractAflatoxin B1 (AFB1) is a pro-carcinogenic compound bioactivated in the liver by cytochromes P450 (CYPs). In mammals, CYP1A and CYP3A are responsible for AFB1 metabolism, with the formation of the genotoxic carcinogens AFB1-8,9-epoxide and AFM1, and the detoxified metabolite AFQ1. Due to climate change, AFB1 cereals contamination arose in Europe. Thus, cattle, as other farm animals fed with grains (pig, sheep and broiler), are more likely exposed to AFB1 via feed with consequent release of AFM1 in milk, posing a great concern to human health. However, knowledge about bovine CYPs involved in AFB1 metabolism is still scanty. Therefore, CYP1A1- and CYP3A74-mediated molecular mechanisms of AFB1 hepatotoxicity were here dissected. Molecular docking of AFB1 into CYP1A1 model suggested AFB1 8,9-endo- and 8,9-exo-epoxide, and AFM1 formation, while docking of AFB1 into CYP3A74 pointed to AFB1 8,9-exo-epoxide and AFQ1 synthesis. To biologically confirm these predictions, CYP1A1 and CYP3A74 knockout (KO) BFH12 cell lines were exposed to AFB1. LC–MS/MS investigations showed the abolished production of AFM1 in CYP1A1 KO cells and the strong increase of parent AFB1 in CYP3A74 KO cells; the latter result, coupled to a decreased cytotoxicity, suggested the major role of CYP3A74 in AFB1 8,9-exo-epoxide formation. Finally, RNA-sequencing analysis indirectly proved lower AFB1-induced cytotoxic effects in engineered cells versus naïve ones. Overall, this study broadens the knowledge on AFB1 metabolism and hepatotoxicity in cattle, and it provides the weight of evidence that CYP1A1 and CYP3A74 inhibition might be exploited to reduce AFM1 and AFBO synthesis, AFB1 toxicity, and AFM1 milk excretion.
Tanshinol ameliorates imiquimod-induced psoriasis by inhibiting M1 macrophage polarization through suppression of the notch signaling pathway
Authors: Liu Junhao , Yong Shuangshuang , Yin Sisi , Feng Jinhong , Lian Caihua , Chen Jie 
Published: June 2024

Abstract
Background
Psoriasis is a common immune-related chronic inflammatory skin disease, often accompanied by significant itching, and once diseased, the course of the disease lasts for most of the lifetime. Tanshinol (TAN) is an active ingredient of Salvia miltiorrhiza, which possesses pharmacological effects such as anti-inflammatory and antioxidant properties. However, the effects of TAN on psoriasis have not been widely reported. Therefore, the aim of this study was to investigate the therapeutic effects and mechanisms of TAN in psoriasis.

Methods
An imiquimod (IMQ)-induced psoriasis mouse model was constructed and treated with different doses of TAN to observe the changes in skin lesion phenotype, macrophage polarization, inflammation and Notch signaling pathway in mice. Further removal of macrophages or inhibition or activation of Notch signaling pathway was performed to examine the changes in skin lesion phenotype, macrophage polarization, inflammation and Notch signaling pathway in mice. In addition, in vitro experiments verified that TAN regulates RAW264.7 macrophage polarization and cytokine secretion through the Notch pathway.

Results
The results showed that TAN alleviated IMQ-induced skin lesions and pathological phenotypes in psoriasis mice and inhibited Notch signaling pathway and M1-type macrophage polarization. Moreover, macrophage clearance and Notch signaling pathway activation inhibited the effect of TAN on psoriasis. Further in vitro experiments showed that Notch agonists reversed the effects of TAN on macrophage polarization and inflammatory cytokines.

Conclusions
Collectively, these findings suggest that TAN may exert a therapeutic effect on psoriasis by inhibiting the Notch signaling pathway and thus M1-type macrophage polarization.
Should I stay or should I go? The influence of environmental conditions on green turtle residence time and outward transit in foraging areas
Authors: Webster Emily G. , Duce Stephanie , Hamann Mark , Murray Nicholas , Shimada Takahiro , Limpus Colin 
Published: June 2024

AbstractForaging animals move through the environment to satisfy their requirements for food, rest, reproduction and risk-avoidance. Understanding how animals respond to changing environmental conditions can help to characterise favourable habitat and determine whether they might be motivated to depart when those habitats become unsuitable. Foraging green turtles are typically residents that scarcely move in response to environmental changes or disturbances. Some individuals though, exhibit high mobility at fine scales. We developed an analysis of Fastloc GPS tracks of 61 green turtles using cox regression models and generalised linear mixed models to investigate the influence of a suite of environmental characteristics on the length of residence time and probability of turtles transitioning between two behavioural modes, “stay” or “go”. Decisions to move (“go”) were influenced by short-term changes in the local environmental conditions. Individuals were more likely to “stay” when temperature increased during their stay and were more likely to “go” when turbidity decreased, and they entered deeper habitats. This result implies that foraging and resting (“staying”) primarily occurs in benthic, shallow, warm habitats, while transit (“going”) is facilitated in deeper, clear water. We also determined that individuals within the green turtle foraging aggregation respond differently to environmental cues to move and hypothesise that a diversity of strategies within a foraging aggregation could confer its resilience to disturbance events. Our study provides new evidence of the factors influencing movements in green turtles and can aid in predicting how they may respond to future changes and enhance risk mitigation efforts through dynamic and adaptive planning.
Assessment of bone marrow edema on dual-energy CT scans in people with diabetes mellitus and suspected Charcot neuro-osteoarthropathy
Authors: Bouman Carlijn M. B. , Mens Marieke A. , Wellenberg Ruud H. H. , Streekstra Geert J. , Bus Sicco A. , Busch-Westbroek Tessa E. , Nieuwdorp Max , Maas Mario 
Published: June 2024

Abstract
Objective
This study aimed to quantitatively assess the diagnostic value of bone marrow edema (BME) detection on virtual non-calcium (VNCa) images calculated from dual-energy CT (DECT) in people with diabetes mellitus and suspected Charcot neuro-osteoarthropathy (CN).

Materials and Methods
People with diabetes mellitus and suspected CN who underwent DECT of the feet (80kVp/Sn150kVp) were included retrospectively. Two blinded observers independently measured CT values on VNCa images using circular regions of interest in five locations in the midfoot (cuneiforms, cuboid and navicular) and the calcaneus of the contralateral or (if one foot was available) the ipsilateral foot. Two clinical groups were formed, one with active CN and one without active CN (no-CN), based on the clinical diagnosis.

Results
Thirty-two people with diabetes mellitus and suspected CN were included. Eleven had clinically active CN. The mean CT value in the midfoot was significantly higher in the CN group (-55.6 ± 18.7 HU) compared to the no-CN group (-94.4 ± 23.5 HU; p < 0.001). In the CN group, the difference in CT value between the midfoot and calcaneus was statistically significant (p = 0.003); this was not the case in the no-CN group (p = 0.357). The overall observer agreement was good for the midfoot (ICC = 0.804) and moderate for the calcaneus (ICC = 0.712). Sensitivity was 100.0% and specificity was 71.4% using a cutoff value of -87.6 HU.

Conclusion
The detection of BME on VNCa images has a potential value in people with diabetes mellitus and suspected active CN.
Sex and survival outcomes in patients with renal cell carcinoma receiving first-line immune-based combinations
Authors: Incorvaia Lorena , Monteiro Fernando Sabino Marques , Massari Francesco , Park Se Hoon , Roviello Giandomenico , Fiala Ondřej , Myint Zin W. , Kucharz Jakub , Molina-Cerrillo Javier , Santini Daniele , Buttner Thomas , Poprach Alexandr , Kopecky Jindrich , Zeppellini Annalisa , Pichler Martin , Buchler Tomas , Pichler Renate , Facchini Gaetano , Fay Andre Poisl , Soares Andrey , Manneh Ray , Iezzi Laura , Kuronya Zsofia , Russo Antonio , Bourlon Maria T. , Bhuva Dipen , Ansari Jawaher , Kanesvaran Ravindran , Grande Enrique , Buti Sebastiano , Santoni Matteo 
Published: June 2024

Abstract
Background
There is an ongoing debate as to whether sex could be associated with immune checkpoint inhibitor (ICI) benefit. Existing literature data reveal contradictory results, and data on first-line immune combinations are lacking.

Method
This was a real-world, multicenter, international, observational study to determine the sex effects on the clinical outcomes in metastatic renal cell carcinoma (mRCC) patients treated with immuno-oncology combinations as first-line therapy.

Results
A total of 1827 mRCC patients from 71 cancer centers in 21 countries were included. The median OS was 38.7 months (95% CI 32.7–44.2) in the overall study population: 40.0 months (95% CI 32.7–51.6) in males and 38.7 months (95% CI 26.4–41.0) in females (p = 0.202). The median OS was higher in males vs. females in patients aged 18-49y (36.9 months, 95% CI 29.0–51.6, vs. 24.8 months, 95% CI 16.8–40.4, p = 0.426, with + 19% of 2y-OS rate, 72% vs. 53%, p = 0.006), in the clear cell histology subgroup (44.2 months, 95% CI 35.8–55.7, vs. 38.7 months, 95% CI 26.0–41.0, p = 0.047), and in patients with sarcomatoid differentiation (34.4 months, 95% CI 26.4–59.0, vs. 15.3 months, 95% CI 8.9–41.0, p < 0.001). Sex female was an independent negative prognostic factor in the sarcomatoid population (HR 1.72, 95% CI 1.15 − 2.57, p = 0.008).

Conclusions
Although the female’s innate and adaptive immunity has been observed to be more active than the male’s, women in the subgroup of clear cell histology, sarcomatoid differentiation, and those under 50 years of age showed shorter OS than males.
Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer
Authors: Chen Rongfa , Liu Linna , Chen Hui , Xing Chao , Zhang Tingting , Pang Yilin , Yang Xunjun 
Published: June 2024

Abstract
Background
The significance of tumor-secreted cytokines in tumor development has gained substantial attention. Nevertheless, the precise role of tumor-related inflammatory cytokines in prostate cancer (PCa) remains ambiguous.

Objectives
To gain deeper insights into the inflammatory response in the process of PCa.

Methods
A total of 233 cases were collected, including 80 cases of prostate hyperplasia as disease control, 65 cases of postoperative prostate cancer and 36 cases of prostate cancer as PCa group. Additionally, 52 patients undergoing physical examinations during the same period were collected as the healthy control. The levels of 12 inflammatory cytokines in peripheral blood samples were analyzed using flow cytometric bead array technology. The levels of total prostate-specific antigen (TPSA) and free prostate-specific antigen (FPSA) in peripheral blood samples were analyzed using electrochemiluminescence technology.

Results
Our findings revealed significant increases in serum IL-8 levels in PCa group compared to the healthy control group. Additionally, IL-6, IL-10, IFN-γ and IL-12p70 levels were markedly elevated in the PCa group compared to the disease control group (all p < 0.05). Conversely, the level of IL-4, TNF-α, IL-1β, IL-17A and IFN-α were lower in the PCa group compared to those in control group. Following surgery, the concentration of IL-6 decreased; whereas, the concentrations of IL-4, TNF-α, IL-17A, IL-1β, IL-12p70, and IFN-α increased, demonstrating significant differences (p < 0.05). The differential upregulation of IL-6 or downregulation of IL-17A in peripheral blood exhibited diagnostic efficacy in PCa patients. Moreover, we observed a significant increase in IL-17A levels, accompanied by decreased of IL-2, IL-4, IL-10, TNF-a, IFN-γ, IL-1β, and IL-12P70 in patients with distant metastasis.

Conclusion
The peripheral blood cytokines are closely associated with the occurrence and development of prostate cancer, especially the serum levels of IL-6 and IL-17A may be useful as potential predictors of PCa diagnosis.
Integration of deep learning and habitat radiomics for predicting the response to immunotherapy in NSCLC patients
Authors: Caii Weimin , Wu Xiao , Guo Kun , Chen Yongxian , Shi Yubo , Chen Junkai 
Published: June 2024

Abstract
Background
The non-invasive biomarkers for predicting immunotherapy response are urgently needed to prevent both premature cessation of treatment and ineffective extension. This study aimed to construct a non-invasive model for predicting immunotherapy response, based on the integration of deep learning and habitat radiomics in patients with advanced non-small cell lung cancer (NSCLC).

Methods
Independent patient cohorts from three medical centers were enrolled for training (n = 164) and test (n = 82). Habitat imaging radiomics features were derived from sub-regions clustered from individual’s tumor by K-means method. The deep learning features were extracted based on 3D ResNet algorithm. Pearson correlation coefficient, T test and least absolute shrinkage and selection operator regression were used to select features. Support vector machine was applied to implement deep learning and habitat radiomics, respectively. Then, a combination model was developed integrating both sources of data.

Results
The combination model obtained a strong well-performance, achieving area under receiver operating characteristics curve of 0.865 (95% CI 0.772–0.931). The model significantly discerned high and low-risk patients, and exhibited a significant benefit in the clinical use.

Conclusion
The integration of deep-leaning and habitat radiomics contributed to predicting response to immunotherapy in patients with NSCLC. The developed integration model may be used as potential tool for individual immunotherapy management.