bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological Characteristics and Genetic Relationship of Red Snappers (Lutjanus timoriensis, Lutjanus malabaricus, Lutjanus erythropterus) in Papuan Waters
Authors: Pranata Bayu , Sala Ridwan , Kusuma Aradea Bujana , Purbani Debora Christin , Mokodongan Daniel Frikli , Sipriyadi Sipriyadi , Azhar Muhamad Ilham 
Published: June 2024

Environmental and genetic variables can exert an influence on alterations in morphological traits. Within fish species inhabiting diverse aquatic settings, there can be observed variations in morphological traits. Genetically, variations in fish morphological characteristics can occur through mating and gene flow. To date, there has been a lack of research conducted on the variability in morphological traits and genetic relationships between Lutjanus timoriensis, L. malabaricus, and L. erythropterus. Thus, the current research aimed to identify variations in the morphological characteristics as well as in the intra- and inter-specific relationships between three red snapper species from the genus Lutjanus. Cytochrome oxidase I (COI) gene was used to study the molecular relationship among species of red snapper. The results showed that L. timoriensis had high intraspecific morphological variation in young individuals. Morphologically, L. timoriensis, L. malabaricus, and L. erythropterus are very similar. Unlike L. malabaricus and L. erythropterus, young and adult L. timoriensis have black patches in the pectoral fin axils. The adult L. erythropterus has a comparatively small mouth, no hump on its head, and no black saddle at the base of its tail. Meanwhile, L. malabaricus has a comparatively large mouth, a head with a hump, and a black saddle at the base of its tail. In terms of body size, L. erythropterus is larger than L. timoriensis and L. malabaricus. Based on NCBI and Bold System data, molecular analyses determined that the observed fish were L. timoriensis, L. malabaricus, L. erythropterus with a similarity of between 99.85 and 100%. The phylogenetic tree construction demonstrated that L. malabaricus, L. timoriensis and L. erythropterus were closely related.
Embarking on the era in new medicine: reshaping the systems of medical education and knowledge
Authors: Han Lefei , Wang Zhaojun , Zhou Xiaonong , Guo Xiaokui 
Published: June 2024

Abstract
Recent revolutions in science and technology have driven human civilisation to an unprecedented level and have promoted the rapid development of modern medicine. New Medicine (NM) is proposed in response to the recent technological revolution and higher requirements for health. The characteristics of NM have been summarised using systems, holistic, intelligent, and precision (SHIP) paradigms. The development of NM has led to substantial changes in healthcare systems and related human resources. However, information regarding how current medical talent cultivation goals adapt to the developments in the era of NM remains unclear. Such adaptations may require a systemic revamping of the current medical education. Recently, medical educators have proposed the construction of New Medical Education (NME), but no unified consensus on its connotation and roadmap exists. Systematically understanding the core essence of NM and identifying the matched strategies of NME are crucial and will benefit future reform strategies that attempt to tackle potential challenges and achieve sustainable goals for medical services. Here, we aim to summarise the changes that have emerged in the field of medicine, how these changes affect the development of medicine, and how the field should prepare for the future medical education.
Evolution of residual stress and microstructure of 2205 duplex stainless steel welded joints during different post-weld heat treatment
Authors: Wan Yu , Song Laimin , Xie Xuefang , Shi Yue 
Published: June 2024

Abstract
Duplex stainless steel (DSS) has been widely used in various applications due to the combination of excellent mechanical properties and corrosion resistance. However, shielded manual arc welding (SMAW) always deteriorates its phase balance and further changes its mechanical properties. Therefore, an appropriate post-weld heat treatment (PWHT) is of the essence to gain the superior performance of the DSS SMAW joint. In this article, the effects of PWHT temperature on the microstructure and residual stress of 2205 DSS SMAW joint were investigated by both experimental and simulation methods. The microstructural characteristics including phase ratio, morphology, grain misorientation, and boundary type were analyzed by the electron backscattered diffraction, while the evolution of residual stress was investigated by a thermal–mechanical coupled finite-element simulation and hole drilling method. The results showed that the residual stress decreased significantly after PWHT, particularly under the higher PWHT temperature. The maximum longitudinal residual stress had dropped by 20.4 and 66.8% at the PWHT temperatures 380 and 1,050°C, which were both far below the yield strength. However, the increase in PWHT temperature promoted the phase proportion imbalance due to the excessive precipitation of intragranular austenite and the formation of low-angle grain boundaries. The fraction of austenite had reached 75.5% when the PWHT temperature was 1,050°C. In order to obtain a reasonable distribution of residual stress and microstructure for the 2205 DSS SMAW joint, it is recommended to perform PWHT at 380°C.
The H2Valdien derivatives regulate the epithelial–mesenchymal transition of hepatoma carcinoma cells through the Hedgehog signaling pathway
Authors: Zhao Xuhui , Shao Xiangxiang , Huang Xiaomin , Dang Chunyan , Wang Ruilin , Li Hongling 
Published: June 2024

Abstract
This research delves into the influence of H2Valdien derivatives on the proliferation, migration, and apoptosis induction in hepatoma carcinoma cells (HepG2, Huh-7, and SMMC-7721), with a specific emphasis on inhibiting epithelial–mesenchymal transition (EMT) through modulation of the Hedgehog (Hh) signaling pathway. Utilizing the cell counting kit-8 method, flow cytometry, TUNEL assay, wound healing, and transwell assays, we observed a dose-dependent growth arrest and apoptosis induction in HepG2, Huh-7, and SMMC-7721 cells. Notably, H2Valdien derivatives exhibited a capacity to reduce migration and invasion, impacting the expression of EMT-associated proteins such as N-cadherin, vimentin, and E-cadherin. Mechanistically, these derivatives demonstrated the inhibition of the Hh signaling pathway by inactivating Sonic Hh (Shh) and smoothened proteins. This study underscores the robust antiproliferative and apoptosis-inducing effects of H2Valdien derivatives on hepatoma carcinoma cells and elucidates their regulatory role in EMT through modulation of the Hh signaling pathway, providing valuable insights for potential therapeutic interventions.
Weather index-based agricultural insurance for flower farmers: Willingness to pay, sales, and profitability perspectives
Authors: Mitra Sandip , Datta Ananna , Dipto Md. Rashid Asef , Khatun Most. Nilufa 
Published: June 2024

Abstract
This study investigated the nexus among the profitability, sales, and willingness to pay (WTP) more for weather index-based agricultural insurance premiums of flower farmers. In addition, the effect of sociodemographic and farm characteristics of flower farmers on their WTP more for insurance premiums was also estimated. A total of 160 flower farmers were selected from Bangladesh using the purposive random sampling technique. Propensity score matching technique was employed to identify the sales difference depending on WTP for insurance premiums while the profitability differences of flower farmers were assessed from different points of view. A binary logistic regression model was used to estimate the effect of sociodemographic and farm characteristics of flower farmers on their WTP more for insurance premiums, while a Likert scale was used to identify the major problems faced by flower farmers. Flower growers are willing to pay a higher premium for insurance when their sales decline. Farmers with lower profitability show a greater WTP higher insurance premiums, whereas those with relatively higher profitability are less inclined to do so. Farmers’ WTP more for insurance premiums decreases with age, education, and farm area, while farmers’ WTP more for insurance premiums increases with experience, training, earning members, marigold farming, and consciousness about natural calamities, pests, and diseases. The most significant problems faced in flower production are high input costs, demand fluctuation, pest and disease attacks, price fluctuation, and loss of production. Thus, the introduction of crop insurance in flower farming may increase profitability and reduce the exposure to risks involved in flower farming. The involvement of younger and more trained farmers in flower farming will increase their WTP more for insurance premiums.
Time Course of Neuromuscular Fatigue During Different Resistance Exercise Loadings in Power Athletes, Strength Athletes, and Nonathletes
Authors: Kotikangas Johanna , Walker Simon , Peltonen Heikki , Häkkinen Keijo 
Published: June 2024

Abstract
Kotikangas, J, Walker, S, Peltonen, H, and Häkkinen, K. Time course of neuromuscular fatigue during different resistance exercise loadings in power athletes, strength athletes, and nonathletes. J Strength Cond Res 38(7): 1231–1242, 2024—Training background may affect the progression of fatigue and neuromuscular strategies to compensate for fatigue during resistance exercises. Thus, our aim was to examine how training background affects the time course of neuromuscular fatigue in response to different resistance exercises. Power athletes (PA, n = 8), strength athletes (SA, n = 8), and nonathletes (NA, n = 7) performed hypertrophic loading (HL, 5 × 10 × 10RM), maximal strength loadings (MSL, 7 × 3 × 3RM) and power loadings (PL, 7 × 6 × 50% of 1 repetition maximum) in back squat. Average power (AP), average velocity (VEL), surface electromyography (sEMG) amplitude (sEMGRMS), and sEMG mean power frequency (sEMGMPF) were measured within all loading sets. During PL, greater decreases in AP occurred from the beginning of SET1 to SET7 and in VEL to both SET4 and SET7 in NA compared with SA (p < 0.01, g > 1.84). During HL, there were various significant group × repetition interactions in AP within and between sets (p < 0.05, ηp
2 > 0.307), but post hoc tests did not indicate significant differences between the groups (p > 0.05, g = 0.01–0.93). During MSL and HL, significant within-set and between-set decreases occurred in AP (p < 0.001, ηp
2 > 0.701) and VEL (p < 0.001, ηp
2 > 0.748) concurrently with increases in sEMGRMS (p < 0.01, ηp
2 > 0.323) and decreases in sEMGMPF (p < 0.01, ηp
2 > 0.242) in all groups. In conclusion, SA showed fatigue resistance by maintaining higher AP and VEL throughout PL. During HL, PA tended to have the greatest initial fatigue response in AP, but between-group comparisons were nonsignificant despite large effect sizes (g > 0.8). The differences in the progression of neuromuscular fatigue may be related to differing neural activation strategies between the groups, but further research confirmation is required.
LGL-leukémia: Dasatinib mellett molekuláris remisszióban lévő chronikus myeloid leukémia ritka szövődménye a splenomegália hátterében
Authors: Timár Botond , Szalóki Gábor , Zajta Erik , Bodó Imre , Szepesi Ágota 
Published: June 2024

A nagy granuláris lymphocyta (LGL) leukémia leggyakrabban normál LGL-sejtek expanzióját kiváltó krónikus antigén stimulációt okozó állapotokkal, mint például krónikus vírus infekcióval, autoimmun betegségekkel és elsősorban hematológiai malignitásokkal társul. A bemutatott esetben az LGL-leukémia egy ritka okát, tünetét és diagnosztikai lehetőségeit tárgyaljuk. A várandós nőbetegnél rutin vérvizsgálat során észlelt thrombocytosis és splenomegália hátterében chronikus myeloid leukémia igazolódott. Az interferon terápiával indult kezelést autoimmun pneumonitis miatt, a másodvonalban elindított glivec terápiát pedig súlyos neutropénia és társuló MRSA sepsis miatt kellett elhagyni. Harmadvonalban császármetszés után indított dasatinib terápia 16 hónap elteltével major molekuláris választ eredményezett. A betegség kezdetétől észlelt splenomegalia és neutropenia azonban nem szűnt meg. További kivizsgálás során JAK2, CALR, MPL mutáció nem igazolódott, a beteg a lép biopsziába nem egyezett bele. A splenomegália hátterében végső soron a perifériás vérben észlelt monoclonalis T-LGL-sejtszaporulat és cytotoxikus T-sejtek csontvelői infiltrációja alapján diagnosztizált LGL-leukémia állhat. Míg a klonális LGL lymphocytosis a dasatinib kezeléshez ismerten társuló gyakori jelenség, klinikai tüneteket okozó esetet nem találtunk az irodalomban. Miután az LGL lymphocytosis chronikus myeloid leukémia válaszra kifejtett kedvező hatásáról számolnak be, és betegünknél az LGL-leukémia csak egy könnyen uralható enyhe neutropeniát okozott, így a dasatinib kezelésen egyelőre nem változtattunk.
Tendencias de la ingeniería multimedia: una mirada glocal desde el sector educativo
Authors: Leal-Pabón Jessica Lorena , Rodríguez-Ibáñez Raúl Eduardo , Mendoza-Gafaro Richard Eliseo 
Published: June 2024

Este artículo aborda el análisis de la Ingeniería Multimedia en el contexto glocal, con el objetivo de analizar las tendencias y su relación con la solución de necesidades de la industria, así como el desarrollo de la Ingeniería Multimedia en Colombia a través de los programas académicos; este programa académico emerge para satisfacer la creciente demanda de profesionales en tecnologías de la información y comunicación, abarcando software multimedia, diseño gráfico, producción audiovisual, videojuegos, entre otros campos emergentes; a nivel global, universidades líderes como Nanyang Technological University, National University of Singapore, Northeastern University, Zhejiang University y Shanghai Jiao Tong University ofrecen programas relacionados; en América Latina se han identificado tendencias en diseño gráfico y posproducción multimedia, videojuegos y 3D, y web y aplicaciones móviles; universidades como UNIACC, La Salle Noroeste y Universidad de La Rioja reflejan esta evolución; en Colombia, la Ingeniería Multimedia se alinea con tendencias como contenidos multimedia, realidad aumentada, sistemas centrados en el usuario y desarrollo web por el crecimiento de las TIC; actualmente existen 14 programas activos que desarrollan competencias en tecnologías de telecomunicaciones y aplicaciones informáticas para producir y distribuir contenidos audiovisuales; estos programas se ofrecen en modalidad presencial y virtual; la investigación se desarrolló mediante el enfoque cualitativo de tipo documental; obteniendo como conclusión que la Ingeniería Multimedia impacta campos como educación, periodismo, salud y entretenimiento; aportando soluciones multimedia innovadoras en estos sectores, como plataformas de telemedicina, software educativo, realidad virtual para entrenamiento, entre otros; este artículo ofrece una visión integral de las tendencias contemporáneas y el impacto de la disciplina en la región; asimismo, destaca la relevancia de la Ingeniería Multimedia en la industria actual y cómo la formación de profesionales es decisiva para el avance tecnológico en América Latina.
Sob os prismas da educação integral e da complexidade: possibilidades para o ensino médio
Authors: De Souza Bezerra Daniella , De Freitas Thaisa Lemos 
Published: June 2024

O texto apresenta aproximações entre ensino médio de tempo integral, educação integral e epistemologia da complexidade. Discute-se o sentido do tempo e da formação destinada à juventude brasileira. Em seguida, discorre-se acerca dos sentidos da educação popular na perspectiva integral. Ao final, aprofunda-se sobre as formas de organização do trabalho pedagógico e curricular na perspectiva complexa, como vias de superação de uma formação resignada diante da realidade.
COVID-19 impact on thrombotic complications in cancer patients
Authors: Vorobev A. V. , Einullaeva S. E. , Borodulin A. S. , Shikina M. A. , Aliev S. A. , Solopova A. G. , Galkin V. N. , Ivanov A. E. , Bitsadze V. O. , Khizroeva J. Kh. , Blinov D. V. , Gris J.-C. , Elalamy I. , Makatsariya A. D. 
Published: June 2024

Aim: to study the features of thrombotic complications in cancer patients during COVID-19 infection, and identify the most significant diagnostic and prognostic criteria.Materials and Methods. Within the framework of cohort non-randomized study, there were analyzed the course of coronavirus infection in 72 hospitalized patients with uterine cancer (n = 22), cervical cancer (n = 19), ovarian cancer (n = 24) as well as vaginal and vulvar cancer (n = 7). All patients hospitalized for COVID-19 were examined and treated in accordance with the Interim guidelines “Prevention, diagnosis and treatment of novel coronavirus infection (COVID-19)” effective at the time of therapy. Additionally, on days 3–7 after hospitalization, a blood test was performed once to determine the level of metalloproteinase ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), ADAMTS-13 activity, ADAMTS-13 inhibitor and von Willebrand factor (vWF) level.Results. It was shown that the average age of the patients was 56.96 ± 7.55 years, the length of hospitalization ranged from 7 to 19 (13.0 ± 3.79) days. The disease severity was assessed by the degree of lung tissue damage based on computed tomography (CT), respiratory failure and development of systemic inflammatory response syndrome (SIRS). During hospitalization, CT-2 was detected in 46 (63.9 %) patients, CT-3 – in 26 (36.1 %) patients; 37 (51.4 %) patients were transferred to the intensive care unit (ICU). Clinically significant deep vein thrombosis (DVT) was diagnosed in 9 (12.5 %) patients, and pulmonary embolism (PE) – in 4 (5.6 %) patients. Of these, 6 cases of DVT and 3 cases of PE were fatal. A total of 14 (19.44 %) patients deceased due to developing acute cardiopulmonary failure. A vWF/ADAMTS-13 ratio greater than 2.1 was found in all ICU patients. Despite anticoagulant therapy, patients with DVT and PE had this ratio higher than 3.3 (4.00 ± 0.48), whereas in all 14 deceased patients it exceeded 2.98.Conclusion. Venous thromboembolism, including PE and DVT, has been identified as а serious complication of COVID-19. An opportunity to predict them early is of special importance because they may lead to serious complications such as disseminated intravascular coagulation, SIRS, cardiopulmonary failure, and death. In patients suffering from cancer infected with COVID-19, not only a decline in ADAMTS-13 activity and level was detected, but also a parallel increase in vWF level. A vWF/ADAMTS-13 ratio may be an early indicator of COVID-19 severity in such patients: a vWF/ADAMTS-13 ratio exceeding 2.1 was common for all ICU patients. Hence, it evidences about a potential for using this parameter to early identify such risk patients who may require more intensive care and medical intervention.
Autopercepção de saúde de idosos participantes de grupos de canto coral na Cidade de Curitiba/Paraná
Authors: Santos Magda da Silva Oliveira Menezes dos , Paula Ana Caroline de , Flores-Gomes Gerson , Oliveira Valdomiro de , Vagetti Gislaine Cristina 
Published: June 2024

Introdução: o canto coral pode ser uma ferramenta protetiva para cognição e aspectos da qualidade de vida de idosos e a autopercepção de saúde tem se mostrado um bom indicador da saúde das pessoas idosas.Objetivo: investigar a autopercepção de saúde de idosos participantes de grupos de canto coral na cidade de Curitiba/Paraná. Materiais e métodos: estudo de abordagem mista, 32 participantes idosos responderam a questionários fechados e a questão “o que é ter saúde para o(a) senhor(a)?”. Os dados descritivos foram apresentados mediante medidas de tendência central e dispersão para variáveis contínuas e distribuição de frequência para as variáveis categóricas. A questão aberta foi analisada por meio de análise temática do conteúdo, utilizando o método de análise de especificidades e análise fatorial combinatório com recursos do software IRAMUTEQ.Resultados: os participantes declararam uma autopercepção de saúde positiva. A saúde é compreendida como um conceito amplo que envolve cinco principais aspectos: relações interpessoais, aspectos físicos, espirituais, conforto e temores. Ter saúde está associado a autonomia para exercer suas atividades.Conclusões: as condições socioeconômicas e estilo de vida são aspectos que irão influenciar diretamente na autopercepção de saúde de pessoas idosas. A participação em atividades sociais pode fomentar as relações interpessoais.
Ad-Dalālah aṣ-Ṣautiyah li Ḥurūf ar-Rawiy fī Dīwān “Syajar El-Lail” li Salah Abdel Sabbour
Authors: Muhammad Zakaria Darlin  , Sherif Alalfy  
Published: June 2024

The narration letters were multiplied in the free verse (free poetry) of its first pioneer in Egypt, the poet Salah Abdel Sabbour, violating the rules of rhyme established by al-Khalil. In the opinion of his followers, this may spoil the unity of the poem's meaning and lead to the corruption of the entire poem. The researchers tried to respond to these old critical opinions by discovering the hidden secrets behind these various rhymes by using stylistic and structural methodologies in addition to literature statistics, to justify the sincerity of the emotion of this new poetry and the extent of its interaction with the conditions of time and place in which the poetry is said. The researchers will apply it in his poetry collection "The Trees of the Night". The stylistic characteristics of these contemporary poems are going to be the proven evidence on the phonetic level in front of the reader. We found that the diversity of the last letter within the poem has enriched the meaning, making the poetry richer in meaning, and at the same time did not diminish the poetic energies.