bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vivo fluid dynamics of the Ventura interatrial shunt device in patients with heart failure
Authors: Pfeiffer Michael , Boehmer John , Gorcsan John , Eguchi Shunsuke , Orihara Yoshiyuki , Perl Michal Laufer , Eigler Neal , Abraham William T. , Villota Julio Nuñez , Lee Elizabeth , Bayés‐Genís Antoni , Moravsky Gil , Kar Saibal , Zile Michael R. , Holcomb Richard , Anker Stefan D. , Stone Gregg W. , Rodés‐Cabau Josep , Lindenfeld JoAnn , Bax Jeroen J. 
Published: May 2024

AbstractAimsInteratrial shunts are under evaluation as a treatment for heart failure (HF); however, their in vivo flow performance has not been quantitatively studied. We aimed to investigate the fluid dynamics properties of the 0.51 cm orifice diameter Ventura shunt and assess its lumen integrity with serial transesophageal echocardiography (TEE).Methods and resultsComputational fluid dynamics (CFD) and bench flow tests were used to establish the flow‐pressure relationship of the shunt. Open‐label patients from the RELIEVE‐HF trial underwent TEE at shunt implant and at 6 and 12 month follow‐up. Shunt effective diameter (Deff) was derived from the vena contracta, and flow was determined by the continuity equation. CFD and bench studies independently validated that the shunt's discharge coefficient was 0.88 to 0.89. The device was successfully implanted in all 97 enrolled patients; mean age was 70 ± 11 years, 97% were NYHA class III, and 51% had LVEF ≤40%. Patency was confirmed in all instances, except for one stenotic shunt at 6 months. Deff remained unchanged from baseline at 12 months (0.47 ± 0.01 cm, P = 0.376), as did the trans‐shunt mean pressure gradient (5.1 ± 3.9 mmHg, P = 0.316) and flow (1137 ± 463 mL/min, P = 0.384). TEE measured flow versus pressure closely correlated (R2 ≥ 0.98) with a fluid dynamics model. At 12 months, the pulmonary/systemic flow Qp/Qs ratio was 1.22 ± 0.12.ConclusionsWhen implanted in patients with advanced HF, this small interatrial shunt demonstrated predictable and durable patency and performance.
Effect of a gamified mobile‐based self‐management application on disease activity index, quality of life, and mental health in adults with inflammatory bowel disease: A protocol of a randomized controlled trial study
Authors: Norouzkhani Narges , Faramarzi Mahbobeh , Bahari Ali , Shokri Shirvani Javad , Shirvani Yeganeh Ebrahimnia , Eslami Saeid , Tabesh Hamed 
Published: May 2024

AbstractBackground and AimsInflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal tract disease subdivided into Crohn's disease (CD) and ulcerative colitis (UC). There is currently no cure for IBD, and individuals with IBD frequently experience a lower health‐related quality of life (HRQOL) than the general population. Gamification has become an increasingly popular topic in recent years. Adapting game design concepts to nongaming contexts represents a novel and potential approach to changing user engagement. This study will be conducted with the aim of evaluating the effect of a gamified mobile‐based self‐management application on disease activity index, quality of life, and mental health in adults with IBD.MethodsA multicenter, parallel, two‐arm, exploratory randomized controlled trial with a 6‐month follow‐up per patient will be designed to compare the impact of the gamified mobile‐based tele‐management system on primary and secondary health outcomes and outpatient visits in 210 patients with all types of IBD which are divided equally into a control group with standard care and an intervention group which will use the developed mobile application named MY IBD BUDDY. All patients will attend study visits at baseline, 12 and 24 weeks, and routine IBD clinic visits or telephone consultations based on randomization group assignment. Disease activity or disease activity index, mental health (anxiety and depression) symptoms, quality of life, self‐efficacy, and IBD‐specific knowledge will be measured at baseline with two follow‐ups at 12 and 24 weeks.ConclusionsIn sum, the outcomes of our trial will demonstrate the impact of the gamified mobile‐based self‐management system on disease activity, quality of life, and anxiety and depression by means of interactive care and patient empowerment.Trial RegistrationIRCT: IRCT20200613047757N1. Registered November 16, 2021. Prospectively registered and visible at OSF (https://doi.org/10.17605/OSF.IO/AWFY9).
Protective effects of Dioscin against sepsis‐induced cardiomyopathy via regulation of toll‐like receptor 4/MyD88/p65 signal pathway
Authors: Zhang Meng , Zhi Deyuan , Liu Pei , Wang Yajun , Duan Meili 
Published: May 2024

AbstractBackgroundDioscin has many pharmacological effects; however, its role in sepsis‐induced cardiomyopathy (SIC) is unknown. Accordingly, we concentrate on elucidating the mechanism of Dioscin in SIC rat model.MethodsThe SIC rat and H9c2 cell models were established by lipopolysaccharide (LPS) induction. The heart rate (HR), left ventricle ejection fraction (LVEF), mean arterial blood pressure (MAP), and heart weight index (HWI) of rats were evaluated. The myocardial tissue was observed by hematoxylin and eosin staining. 4‐Hydroxy‐2‐nonenal (4‐HNE) level in myocardial tissue was detected by immunohistochemistry. Superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) activities in serum samples of rats and H9c2 cells were determined by colorimetric assay. Bax, B‐cell lymphoma‐2 (Bcl‐2), toll‐like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), phosphorylated‐p65 (p‐p65), and p65 levels in myocardial tissues of rats and treated H9c2 cells were measured by quantitative real‐time PCR and Western blot. Viability and reactive oxygen species (ROS) accumulation of treated H9c2 cells were assayed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and dihydroethidium staining assays.ResultsDioscin decreased HR and HWI, increased LVEF and MAP, alleviated the myocardial tissue damage, and reduced 4‐HNE level in SIC rats. Dioscin reversed LPS‐induced reduction on SOD, CAT, GSH, and Bcl‐2 levels, and increment on Bax and TLR4 levels in rats and H9c2 cells. Overexpressed TLR4 attenuated the effects of Dioscin on promoting viability, as well as dwindling TLR4, ROS and MyD88 levels, and p‐p65/p65 value in LPS‐induced H9c2 cells.ConclusionProtective effects of Dioscin against LPS‐induced SIC are achieved via regulation of TLR4/MyD88/p65 signal pathway.
Knowledge framework of intravenous immunoglobulin resistance in the field of Kawasaki disease: A bibliometric analysis (1997−2023)
Authors: Zhang Jiaying , Huang Hongbiao , Xu Lei , Wang Shuhui , Gao Yang , Zhuo Wenyu , Wang Yan , Zheng Yiming , Tang Xuan , Jiang Jiaqi , Lv Haitao 
Published: May 2024

AbstractBackgroundKawasaki disease (KD) is an autoimmune disease with cardiovascular disease as its main complication, mainly affecting children under 5 years old. KD treatment has made tremendous progress in recent years, but intravenous immunoglobulin (IVIG) resistance remains a major dilemma. Bibliometric analysis had not been used previously to summarize and analyze publications related to IVIG resistance in KD. This study aimed to provide an overview of the knowledge framework and research hotspots in this field through bibliometrics, and provide references for future basic and clinical research.MethodsThrough bibliometric analysis of relevant literature published on the Web of Science Core Collection (WoSCC) database between 1997 and 2023, we investigated the cooccurrence and collaboration relationships among countries, institutions, journals, and authors and summarized key research topics and hotspots.ResultsFollowing screening, a total of 364 publications were downloaded, comprising 328 articles and 36 reviews. The number of articles on IVIG resistance increased year on year and the top three most productive countries were China, Japan, and the United States. Frontiers in Pediatrics had the most published articles, and the Journal of Pediatrics had the most citations. IVIG resistance had been studied by 1889 authors, of whom Kuo Ho Chang had published the most papers.ConclusionResearch in the field was focused on risk factors, therapy (atorvastatin, tumor necrosis factor‐alpha inhibitors), pathogenesis (gene expression), and similar diseases (multisystem inflammatory syndrome in children, MIS‐C). “Treatment,” “risk factor,” and “prediction” were important keywords, providing a valuable reference for scholars studying this field. We suggest that, in the future, more active international collaborations are carried out to study the pathogenesis of IVIG insensitivity, using high‐throughput sequencing technology. We also recommend that machine learning techniques are applied to explore the predictive variables of IVIG resistance.
Parental sensitivity and family conversation: A naturalistic longitudinal study with both mothers and fathers across three time‐points in early infancy
Authors: Fink Elian , Foley Sarah , Browne Wendy , Hughes Claire 
Published: May 2024

AbstractParental verbal sensitivity is known to promote child language skills, but few studies have considered: (a) links between global (i.e., verbal, behavioral, and affective) measures of parental sensitivity and infant‐initiated conversations, an important precursor to language development; (b) whether maternal and paternal sensitivity show similar links with infant‐initiated conversation; or (c) the transactional role of infant conversation for later parental sensitivity. Addressing these gaps, this study of 186 British first‐time parents (93 families) examines the developmental dynamics between parental sensitivity and infant communication across the first year of life. We explore; (i) the role of maternal and paternal sensitivity (assessed during structured home observations at 4 months post‐partum) for parent‐infant conversational interactions at 7 months (indexed by day‐long naturalistic recordings), and (ii) whether these mother‐infant and father‐infant conversations at 7 months shape maternal and paternal sensitivity at 14 months (also assessed via structured home observations). For both male and female infants, maternal (but not paternal) sensitivity at 4 months predicted infant vocalisations and conversational initiation at 7‐months. By contrast, neither index of infant talk predicted maternal or paternal sensitivity at 14 months. Together these findings refine understanding of theoretical models of social development and suggest new possibilities for future research.
Molecular Epidemiology and Antifungal Susceptibility Profile in Nakaseomyces glabrata Species Complex: A 5‐Year Countrywide Study
Authors: Salimi Maryam , Javidnia Javad , Faeli Leila , Moslemi Azam , Hedayati Mohammad Taghi , Haghani Iman , Aghili Seyed Reza , Moazeni Maryam , Badiee Parisa , Roudbari Maryam , Zarrinfar Hossein , Mohammadi Rasoul , Lotfali Ensieh , Nouripour‐Sisakht Sadegh , Seyedmousavi Seyedmojtaba , Shokohi Tahereh , Abastabar Mahdi 
Published: May 2024

ABSTRACTBackgroundThe current study aimed to identify Iranian Nakaseomyces (Candida) glabrata complex species in the clinical isolates and determine their antifungal susceptibility profile.MethodsIn total, 320 N. glabrata clinical isolates were collected from patients hospitalized in different geographical regions of Iran. The initial screening was performed by morphological characteristics on CHROMagar Candida. Each isolate was identified by targeting the D1/D2 rDNA using a multiplex‐PCR method. To validate the mPCR method and determine genetic diversity, the ITS‐rDNA region was randomly sequenced in 40 isolates. Additionally, antifungal susceptibility was evaluated against nine antifungal agents following the CLSI M27‐A4 guidelines.ResultsAll clinical isolates from Iran were identified as N. glabrata. The analysis of ITS‐rDNA sequence data revealed the presence of eight distinct ITS clades and 10 haplotypes among the 40 isolates of N. glabrata. The predominant clades identified were Clades VII, V, and IV, which respectively accounted for 22.5%, 17.5%, and 17.5% isolates. The widest MIC ranges were observed for voriconazole (0.016–8 μg/mL) and isavuconazole (0.016–2 μg/mL), whereas the narrowest ranges were seen with itraconazole and amphotericin B (0.25–2 μg/mL).ConclusionHaplotype diversity can be a valuable approach for studying the genetic diversity, transmission patterns, and epidemiology of the N. glabrata complex.
Dietary characteristics associated with the risk of non‐alcoholic fatty liver disease and metabolic dysfunction‐associated steatotic liver disease in non‐obese Japanese participants: A cross‐sectional study
Authors: Taniguchi Hirokazu , Ueda Miho , Sano Fumika , Kobayashi Yukiko , Shima Takatomo 
Published: May 2024

AbstractBackground and AimDietary characteristics associated with non‐alcoholic fatty liver disease (NAFLD) and metabolic dysfunction‐associated steatotic liver disease (MASLD) in non‐obese patients remain to be elucidated. This study examined the association of NAFLD and MASLD with dietary characteristics according to obesity status.MethodsWe performed a cross‐sectional study of 15 135 participants (n = 7568 men and 7567 women) aged 35–74 years using data of annual health checks between 2008 and 2020. Obesity was defined as BMI ≥ 25 kg/m2. Diagnosis of fatty liver was based on abdominal ultrasonography. Fatty‐liver‐related dietary characteristics were assessed using a self‐administered questionnaire.ResultsFor non‐obese participants, NAFLD was found in 31.0% of men and 19.4% of women. Non‐obese MASLD was found in 27.6% of men and 18.1% of women. Multivariable‐adjusted stepwise logistic regression analysis indicated that, in males, both non‐obese NAFLD and non‐obese MASLD were significantly and negatively associated with “often eat sesame/nuts”, and positively associated with “often eat noodles/rice bowl” and “often eat evening meal” (P < 0.05). For non‐obese women, both NAFLD and MASLD were significantly and positively associated with “often eat sweet buns/bread with fillings” (P < 0.05). Adjusted analyses showed that all dietary characteristics were not significantly associated with the risk of NAFLD/MASLD in obese men and women.ConclusionThis cross‐sectional study indicates the existence of sex and obesity differences in the association of NAFLD and MASLD with dietary characteristics. Our findings suggest that some dietary characteristics are associated with NAFLD and MASLD prevalence in non‐obese Japanese participants.
Clinical validation and accuracy assessment of the Capsule Endoscopy‐Crohn's Disease index (CE‐CD)
Authors: Arcos‐Machancoses José Vicente , Kapoor Akshay , Schluckebier Dominique , Thomson Mike 
Published: May 2024

AbstractObjectivesTo compare the recently proposed Capsule Endoscopy‐Crohn's Disease index (CE‐CD) to pre‐existing capsule endoscopy (CE) scores, to measure its precision and accuracy to predict adverse clinical outcomes in children with Crohn's disease (CD).MethodsChildren with CD who underwent CE at diagnosis and had, at least, 1‐year follow‐up postprocedure were selected. Capsule study was viewed and the different indices were independently scored by two trained paediatric gastroenterologists. The relationship between pre‐existing scores and CE‐CD was assessed by linear regression analysis. Clinical outcomes prediction assessment was based on receiver operating characteristics curves, survival analysis and Cox regression. Finally, interobserver agreement was measured.ResultsFifty‐nine patients were finally included. CE‐CD showed a strong positive correlation with the Lewis score (ρ = 0.947) and the Capsule Endoscopy Crohn's Disease Activity Index (CECDAI) (ρ = 0.982). Both CE‐CD and CECDAI were significant predictors of treatment escalation (hazard ratio 1.07 and 1.09, respectively, with both p‐values < 0.01). However, no score predicted risk of hospital admission, surgery or clinical/endoscopic relapse. The presence of moderate‐to‐severe small bowel (SB) inflammation, defined as a score of ≥9 on CE‐CD, provided a hazard ratio of treatment escalation of 2.6 (95% confidence interval: 1.3–5.3). This cut‐off provided the optimal sensitivity/specificity pair: 48.4%/89.3%. No interobserver misclassification among inflammation categories given by CE‐CD were observed (kappa 100%).ConclusionCE‐CD is a useful tool to document SB inflammation in children with CD. It correlates strongly with classical scores, can better predict need for treatment escalation and shows good interobserver agreement.
Knowledge, attitude, intentional practice and individualized determinants of COVID‐19 vaccine uptake among adults: A cross‐sectional study in Tanzania
Authors: Nassoro Amimu A. , Millanzi Walter C. , Herman Patricia Z. 
Published: May 2024

AbstractAimThe study assessed the knowledge, attitude, intentional practice and individualized factors of COVID‐19 vaccine uptake among adults in Tanzania.DesignHospital‐based analytical cross‐sectional study.MethodsQuantitative approaches were adopted to study 312 randomly selected adults using an interviewer‐administered structured questionnaire. Descriptive analysis established frequencies and percentages of variables at a 95% confidence interval and a 5% significance level.ResultsMean age was 24.66 ± 6.503 of which 61.5% were males. 86.9% of them were not vaccinated. 57.7% of respondents had inadequate knowledge about the COVID‐19 vaccine, and 61.5% had negative attitudes towards it. 63.8% of adults demonstrated an unwillingness to be vaccinated. Participants' sociodemographic characteristics profiles were significantly associated with COVID‐19 vaccine knowledge, attitude and willingness to uptake it (p < 0.05). Findings highlight the need for large‐scale interventions to address the low uptake vaccine. Adults' willingness to get a coronavirus vaccine was comparatively low. Sociodemographic profiles, knowledge and attitude were associated significantly with low uptake of the COVID‐19 vaccine among adults in Tanzania.
Cluster analysis of patients with alcohol use disorder featuring alexithymia, depression, and diverse drinking behavior
Authors: Kurihara Kazuhiro , Enoki Hiroyuki , Shinzato Hotaka , Takaesu Yoshikazu , Kondo Tsuyoshi 
Published: May 2024

AbstractAimThis study aimed to identify subgroups of alcohol use disorder (AUD) based on a multidimensional combination of alexithymia, depression, and diverse drinking behavior.MethodWe recruited 176 patients with AUD, which were initially divided into non‐alexithymic (n = 130) and alexithymic (n = 46) groups using a cutoff score of 61 on the Toronto Alexithymia Scale (TAS‐20). Subsequently, the profiles of the two groups were compared. Thereafter, a two‐stage cluster analysis using hierarchical and K‐means methods was performed with the Z‐scores from the TAS‐20, the Quick Inventory of Depressive Symptomatology Self‐Report Japanese Version, the 12‐item questionnaire for quantitative assessment of depressive mixed state, and the 20‐item questionnaire for drinking behavior pattern.ResultsIn the first analysis, Alexithymic patients with AUD showed greater depressive symptoms and more pathological drinking behavior patterns than those without alexithymia. Cluster analysis featuring alexithymia, depression, and drinking behavior identified three subtypes: Cluster 1 (core AUD type) manifesting pathological drinking behavior highlighting automaticity; Cluster 2 (late‐onset type) showing relatively late‐onset alcohol use and fewer depressive symptoms or pathological drinking behavior; and Cluster 3 (alexithymic type) characterized by alexithymia, depression, and pathological drinking behavior featuring greater coping with negative affect.ConclusionThe multidimensional model with alexithymia, depression, and diverse drinking behavior provided possible practical classification of AUD. The alexithymic subtype may require more caution, and additional support for negative affect may be necessary due to accompanying mood problems and various maladaptive drinking behaviors.
Convergence analysis of a L1‐ADI scheme for two‐dimensional multiterm reaction‐subdiffusion equation
Authors: Jiang Yubing , Chen Hu 
Published: May 2024

AbstractIn this paper, we consider the numerical approximation for a two‐dimensional multiterm reaction‐subdiffusion equation, where we adopt an alternating direction implicit (ADI) method combined with the L1 approximation for the multiterm time Caputo fractional derivatives of orders between 0 and 1. Stability and convergence of the full‐discrete L1‐ADI scheme are established. The final convergence in time direction is point‐wise, that is, at . Numerical results are given to confirm our theoretical results.
Clonal evolution and relapse in early‐stage follicular lymphoma – a tree with many branches†
Authors: Fend Falko , Quintanilla‐Martinez Leticia 
Published: May 2024

AbstractFollicular lymphoma (FL) is an indolent B‐cell neoplasm characterised by multistep evolution from premalignant precursor cells carrying the hallmark t(14;18) translocation in the majority of cases. In a new article in The Journal of Pathology, samples of relapsed early‐stage FL – primary manifestation and relapse with or without transformation – initially treated with radiotherapy only, were studied for clonal relationships and evolution. Using somatic mutations and the rearranged immunoglobulin sequences as markers, the majority of paired lymphoma samples showed so‐called branched evolution from a common, possibly premalignant progenitor cell, with both shared and private mutations. In addition, clonally unrelated cases were identified. This and previous studies with similar findings clearly document that relapse or transformation of FL in many instances not necessarily represents a linear progression of disease due to acquisition of additional mutations and therapy resistance, but rather new outgrowths derived from a pool of clonally related, long‐lived, and low proliferating precursor cells, or even unrelated second neoplasms. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
Improved performance of epoxy resin coating with the modification of dopamine doped Ti4O7
Authors: Lin Huanhuan , Wang Yanli , Li Weihua 
Published: May 2024

AbstractIn this paper, a dense and well‐adherent polydopamine‐Ti4O7/epoxy resin (PDA‐Ti4O7/EP) composite coating is successfully prepared. The modified grafting of Ti4O7 by polydopamine (PDA) is achieved through the coordination complexation of unstable catechol groups in PDA with coordination unsaturated Ti atoms in Ti4O7. The potentiodynamic polarization curve and electrochemical impedance spectroscopy test results show that the performance of the composite coating is improved compared with that of the pure epoxy coating, and the composite coating slows down the penetration of electrolytes and aggressive ions and improves the corrosion resistance. The composite coating with 2 wt.% PDA‐Ti4O7 filler shows the best corrosion resistance, and its |Z|0.01 Hz remains above 1011 Ω cm2 after 30 days of immersion in 3.5 wt% NaCl solution. This can be attributed to the good barrier property of PDA‐Ti4O7 filler, which carries NH2 and OH reactive groups, interacting with the resin and matrix to improve the dispersion of the filler and the adhesion of the composite coating. The NH2 group reacts with the epoxy group in the epoxy resin in a ring‐opening reaction, which avoids the agglomeration of the filler and the uniformly dispersed filler fills the pores in the coating due to curing to improve the denseness of the coating and give full play to the barrier property of the filler. At the same time, the hydrogen bonding between the filler and the OH group in the resin and the substrate increases the adhesion of the coating. In addition, the unstable catechol group in PDA chelates with iron ions to further improve the overall corrosion resistance of the coating.Highlights
A dense and well‐adherent PDA‐Ti4O7/EP coating is successfully prepared.
PDA connect with Ti4O7 through coordination of catechol groups and Ti atom.
PDA‐Ti4O7 are chemically bonded to the EP through a ring‐opening reaction.
PDA‐Ti4O7 improves the crosslinking density and barrier ability of the coating.