bluuebunny/crossref_metadata_2025_split huggingface dataset:
Notoginsenoside R1 decreases intraplaque neovascularization by governing pericyte‐endothelial cell communication via Ang1/Tie2 axis in atherosclerosis
Authors: Li Yuan , Zhang Lei , Yang Wenqing , Lin Lin , Pan Jinyuan , Lu Mengkai , Zhang Zhiyuan , Li Yunlun , Li Chao 
Published: June 2024

AbstractAtherosclerosis represents the major cause of mortality worldwide and triggers higher risk of acute cardiovascular events. Pericytes‐endothelial cells (ECs) communication is orchestrated by ligand‐receptor interaction generating a microenvironment which results in intraplaque neovascularization, that is closely associated with atherosclerotic plaque instability. Notoginsenoside R1 (R1) exhibits anti‐atherosclerotic bioactivity, but its effect on angiogenesis in atherosclerotic plaque remains elusive. The aim of our study is to explore the therapeutic effect of R1 on vulnerable plaque and investigate its potential mechanism against intraplaque neovascularization. The impacts of R1 on plaque stability and intraplaque neovascularization were assessed in ApoE−/− mice induced by high‐fat diet. Pericytes‐ECs direct or non‐direct contact co‐cultured with VEGF‐A stimulation were used as the in vitro angiogenesis models. Overexpressing Ang1 in pericytes was performed to investigate the underlying mechanism. In vivo experiments, R1 treatment reversed atherosclerotic plaque vulnerability and decreased the presence of neovessels in ApoE−/− mice. Additionally, R1 reduced the expression of Ang1 in pericytes. In vitro experiments demonstrated that R1 suppressed pro‐angiogenic behavior of ECs induced by pericytes cultured with VEGF‐A. Mechanistic studies revealed that the anti‐angiogenic effect of R1 was dependent on the inhibition of Ang1 and Tie2 expression, as the effects were partially reversed after Ang1 overexpressing in pericytes. Our study demonstrated that R1 treatment inhibited intraplaque neovascularization by governing pericyte‐EC association via suppressing Ang1‐Tie2/PI3K‐AKT paracrine signaling pathway. R1 represents a novel therapeutic strategy for atherosclerotic vulnerable plaques in clinical application.
Geometric tracking control of a multi‐rotor UAV for partially known trajectories
Authors: Kumar Yogesh , Roy S. B. , Sujit P. B. 
Published: June 2024

AbstractThis article presents a trajectory‐tracking controller for multi‐rotor unmanned aerial vehicles (UAVs) in scenarios where only the desired position and heading are known without the higher‐order derivatives. The proposed solution modifies the state‐of‐the‐art geometric controller, effectively addressing challenges related to the non‐existence of the desired attitude and ensuring positive total thrust input for all time. We tackle the additional challenge of the non‐availability of the higher derivatives of the trajectory by introducing novel nonlinear filter structures. We formalize theoretically the effect of these filter structures on the system error dynamics. Subsequently, through a rigorous theoretical analysis, we demonstrate that the proposed controller leads to uniformly ultimately bounded system error dynamics. To demonstrate the controller's effectiveness and potential to enhance multi‐rotor performance and reliability in practical applications, we present a simulation study considering two examples with time‐varying trajectories.
Multilingual learners’ exposure to science and language inputs in elementary school: ¿Qué sabemos?
Authors: Boza Lelydeyvis , Chris Curran F. , Harris‐Walls Katharine , Tan Tiffany S. , Deig Amber , Pacheco Mark B. 
Published: June 2024

AbstractAs linguistic diversity continues to increase in the United States public school system, schools are expected to meet the needs of their ever‐changing student body. While much attention within education research has understandably focused on multilingual learners’ (MLs) English language acquisition, an emergent body of work points to science as an important subject for attention among elementary MLs. We suggest that understanding what science and language inputs are afforded to MLs in schools can contribute to understanding the needs and opportunities for enhancing MLs’ science learning. This study leveraged nationally representative data from the Early Childhood Longitudinal Study of 2010–2011 to explore the science and language inputs available to MLs in elementary school. Using descriptive statistics, our analysis of science and language inputs provides evidence on what MLs have, or do not have, access to inside of their schools. Science inputs appear to be relatively evenly distributed across classrooms serving non‐MLs, MLs, and subgroups therein. In comparison, language inputs are differentially distributed across ML subgroups, but they are distributed in ways that may align with student needs. However, while the science inputs do not necessarily vary across subgroups, the language inputs do, and this may affect how students can engage with science inputs. In understanding what science and language inputs MLs are afforded, this study provides a foundation for how to improve formal learning environments for them, especially regarding science learning.
Facile Fabrication of Hydroxyapatite and Bentonite Encapsulated Biopolymeric Hybrid Composites for Selective Removal of Methylene Blue
Authors: Sathiyajothi Vellaiyapillai , Viswanathan Natrayasamy , Naushad Mu. 
Published: June 2024

AbstractDyeing industries release their hazardous dyeing effluents into the environment which affects the human health and ecosystem. Hence, the removal of dye from waste‐water is mandatory one. In this present study, focus on the fabrication of bio‐clay‐ceramic hybrid composites by dispersing bentonite (BT) clay and ceramic hydroxyapatite (HA) into alginate (Alg) and gelatin (Gel) polymeric matrixes by in‐situ method which gives BTHAAlg and BTHAGel hybrid composites for methylene blue (MB) removal. The various adsorption influencing parameters such as shaking time, adsorbent dosage, pH and initial MB concentration were optimized under batch method. The highest MB adsorption capacities of BTHAAlg and BTHAGel composites were found to be 43.70 and 47.50 mg/g respectively with optimized conditions of 100 mg/L of initial MB concentration, 40 min shaking time and 0.1 g dosages. In pH studies, the high MB adsorption capacity of bio‐clay‐ceramic composites were noticed at pH 11. The characterization techniques like FTIR, SEM and EDAX analysis were performed to find the physico‐chemical properties of bio‐clay‐ceramic composites. The equilibrium data of hybrid composites towards MB adsorption was well fitted with Langmuir isotherm model than D‐R and Fruendlich models because of higher r and low sd values. The negative values of ▵Go at three different temperatures (303, 313 and 323 K) indicate that the spontaneous nature of MB adsorption, while positive values of ΔHo and ΔSo revealed that the MB adsorption onto hybrid composites was endothermic in nature and more randomness occurred at solid/liquid interfaces. In kinetic studies, the MB adsorption onto hybrid composites was well fitted with pseudo‐second‐order and intra‐particle diffusion models. The electrostatic attraction and hydrogen bonding plays a dominant role in MB adsorption onto BTHAAlg and BTHAGel bio‐clay‐ceramic composites. The regeneration studies proposed that the hybrid composites can be reusable upto five cycles. Hence, the developed bio‐clay‐ceramic hybrid composites were act as best adsorbents for MB removal.
Imidazo[1,2‐a]Quinoxaline‐2‐Carbonitrile Derivative (RA‐22) Inhibits Self‐Renewal and Growth of Cancer Stem and Cancer Cells via Downregulating AKT Pathway
Authors: Kumar Pramit , Prasad Yadav Umesh , Joshi Gaurav , Arora Sahil , Kumar Manvendra , Chatterjee Joydeep , Chandra Vikas , Singh Sandeep , Kumar Raj , Kumar Santosh 
Published: June 2024

AbstractEGFR activation in colorectal and breast cancer stimulates downstream pathways like Ras/Raf/MEK/ERK and PI3 K/Akt, fostering cell proliferation, invasion, metastasis, and therapy resistance, underscoring its significance as a therapeutic target in both cancers. In the present work, we rationally designed (E)‐4‐methyl‐1‐((3‐oxo‐1‐phenylbutyl)amino)‐4‐styryl‐4,5‐dihydroimidazo[1,2‐a]quinoxaline‐2‐carbonitrile (RA‐22) as EGFR inhibitor. Our research investigates the role of RA‐22 as a target molecule for EGFR, exploring its anticancer potential and mechanism of action across breast cancer and colorectal cancer cell lines. The in‐vitro studies showed its cytotoxic response towards MDA‐MB‐231 and HCT‐116 and its inhibitory effect on cancer stem cells in mammosphere/spheroid culture. The compound downregulates the oncogenic signalling proteins like STAT‐3, AKT, PAN‐AKT, and ERK and also reduces the expression of the anti‐apoptotic protein Bcl‐2 and increases the apoptotic proteins like Cleaved‐PARP, Cleaved‐Caspase‐3, and Cleaved‐Caspase‐9.
Synthesis and in vitro Antiproliferative Evaluation and Molecular Docking Studies of Novel Chalcone‐Phosphonates Derivatives as Anticancer Agents
Authors: Mishra Shweta , Verma Ekta , Debnath Biplab , Chawla Amit , Shama Khandige Prasanna , Saxena Bhagawati , Sahoo Nityananda , Jana Pradeep 
Published: June 2024

AbstractBased on the wide range of pharmacological aspects related to organophosphates, a new type of chalcone‐phosphonate containing derivatives were synthesized by the reaction of dialkyl phosphite and substituted chalcones using anhydrous Mg(ClO4)2 at 80 °C under solvent‐free conditions. The resulting compounds were evaluated for anti‐proliferative activity in vitro against a panel of three human cancer cell lines: MCF7, HeLa, and A549 cell lines. Compound 3 l, 3 m, and 3 p exhibited anti‐proliferative activity against MCF7 and HeLa, with IC50 values of 1.12 μM, 1.63 μM, 1.09 μM and 1.29 μM, 1.44 μM, 2.40 μM respectively. The molecular docking study showed that the synthesized derivatives have good binding ability in the active site of the Vaccinia H1‐related (VHR) phosphatase (PDB: 3F81), PI3‐ kinase (PDB: 3R7Q), androgen receptor (PDB: 3V49) and VEGFR2 kinase (PDB: 3VHE). Finally, in silico pharmacokinetic (ADME) and toxicity studies revealed that compounds have the drug‐like feature for the favourable bioavailability. In conclusion, this work confirmed the potency of chalcone‐phosphonates derivatives for the further optimization of potential anti‐ proliferative agents.
Yttrium Silicate‐Coated Carbon Fiber Reinforced Phenolic Aerogel‐like Composites with Low Density and Low Ablation
Authors: Sun Jin , Wang Shuang , Huang Jie , Huang Haiming , Yao Jun 
Published: June 2024

AbstractThe evolution of hypersonic vehicles has raised higher requirements for thermal protection materials, which have become the focus of research on how to meet the lightweight and less ablative. Herein, a yttrium silicate‐coated carbon fiber felts (YS‐CFs) reinforced phenolic aerogel‐like (PR) composites were prepared. The YS‐CFs/PR with the addition of 12 % hexamethylenetetramine exhibited low density (0.540 g/cm3), low thermal conductivity (0.145 W/(m⋅K)), and good thermal stability. Specifically, under an oxyacetylene flame examination with 2.44 MW/m2 heated for 120 s, its mass ablation rates (9.833 mg/s) and line ablation rates (5 μm/s) were decreased by 40.8 % and 32.6 %, respectively, compared to others. The results show that the composites with these combined properties can meet the requirements for thermal protection materials in the field of hypersonic vehicles.
Review On Strategies For the Design and Synthesis of Flower‐Like Bi2WO6 and BiOX (X=F, Cl, Br, I) Composites for Photocatalytic Environmental Remediation
Authors: Deshmukh Shubham Avinash , Suresh Selvaraj , Bhuse Darpan Vijaykumar , Raut Subodh Uttamrao , Reddy M. Vijaya Bhaskar , Ravichandran S. 
Published: June 2024

AbstractIn latest events, water pollution has posed an immense threat, and its sustainable treatment is a topic of concern. Among myriad of water treatment, research community has lensed towards sustainable heterogeneous photocatalysis especially, inorganic semiconductors. Bismuth tungstate a pristine Aurivillius compound with unique crystal structure, exceptional photochemical stability, and strong redox abilities but minimum visible light absorption and quick carrier recombination are its caveats, these caveats are circumvented by synthesizing BiOX (X=F, Cl, Br and I) composites with surface modifiers, doping with hetero atoms (metals and non‐metals), construction of the heterojunction and amalgamation of carbon materials. The heart of this review is strategic engineering of flower‐like morphology photocatalyst synthesis and optical properties, it also discusses the charge transfer kinetics, photocatalytic performance, and durability. The flower‐like morphology highlighted in this review is due to its ability to harvest light, providing larger specific surface area which introduces more active sites and efficient excitons generation. The comprehensive tabulated data in this review will help the actively engaged research community in Bismuth heterogenous photocatalysis. It also sheds light on the future view of environmental remediation via photocatalytic developments.
Nitration of Derivatives of Imidazo[1,5‐a]pyridine via C−H Functionalization with Fe(NO3)3 ⋅ 9H2O as a Promoter and a Nitro Source
Authors: Yang Xiaohan , Wang Biqin , Zhang Qian , Szekely Aron , Wu Mengxiang , Li Yahong 
Published: June 2024

AbstractAn additive‐free, mild, and regioselective C(1)−H nitration of imidazo[1,5‐a]pyridine derivatives was developed. This protocol features the use of easily handled, commercially available, and nontoxic Fe(NO3)3 ⋅ 9H2O both as a nitration source and as a promoter, exhibits good functional group compatibility, and generates the desired nitrated products in acceptable to excellent yields. Mechanistic studies proposed that the nitration reaction may involve a radical C−H functionalization process.
Enhanced Photoelectrocatalytic Activity of CuO/CuNb2O6 Heterojunction Photocathodes for Efficient Solar Water Splitting
Authors: Li Zhixue , Lin Zeze , Zhang Yuheng , Hu Junhua , Song Angang 
Published: June 2024

AbstractCuNb2O6 (CNO), a novel ternary metal oxide, has garnered much attention since it has a modest bandgap and potentially high current density. However, the reported photocurrent density so far is still much lower than the theoretical value. In this study, a CuO/CNO photoelectrode heterojunction was synthesized for the first time by using a solution‐based spray pyrolysis method. The properties of the heterojunction were investigated through various characterization techniques, including Mott‐Schottky analysis, time‐resolved photoluminescence, surface photovoltage analysis, chopper linear sweep voltammetry, and electrochemical impedance spectroscopy. The optimized maximum photocurrent density of the CuO/CNO heterojunction was ~0.75 mA/cm2 at 0.4 V vs. reversible hydrogen electrode (RHE), which is 2.8 times higher compared to the bare CNO photocathode. The improvement is attributed to the enhanced transport properties of charge carriers and promoted better separation of photo‐generated electrons and holes in the photoelectrode by the heterostructure. By the generation of heterojunctions, this work provides a new foundation for the design and construction of photocathodes with high charge separation efficiencies. This is also useful for future studies on water decomposition using heterojunctions as photoelectrode materials.
A Polymer‐Functionalized GO Composite Prepared through Pickering Emulsion Polymerization for Selective Removal of Zr from Acidic Solutions
Authors: Vignesh Murugesan Veera , Suneesh Asokan Sudha , Selvan Balakrishnan Robert , Jain Ashish , Madapu Kishore Kumar , Ramanathan Nagarajan 
Published: June 2024

AbstractFor the selective removal of Zr from PUREX originated acidic aqueous waste of metallic fuel, an adsorbent based on graphene oxide (GO)‐polystyrene composite functionalized with amide functional group was developed. Improved Hummers’ oxidation of graphite powder was utilized to produce GO and the amide moiety was linked to GO via chemical functionalization. The amide modified GO was converted to GO‐polystyrene composite microspheres through pickering emulsion assisted route. FT‐IR, XRD and SEM analyses were employed to characterize the composite adsorbent. The adsorption behavior of Zr was examined under varying experimental conditions. Adsorption was modeled using several adsorption and kinetic models. The Zr adsorption capacity calculated based on the Langmuir adsorption isotherm and Pseudo‐first‐order models exhibited a close agreement. Adsorption studies using simulated U‐Pu‐Zr originated PUREX aqueous waste signifies the superior Zr‐adsorption capacity (~50 mg g−1), even in the presence of other possible interfering elements present in SHLLW.
enCloud: Aspect‐oriented trusted service migration on SGX‐enabled cloud VM
Authors: Yoo Seehwan , Kim Youngpil , Park Hyunchan , Hwang Jaehyun , Kim Kitak 
Published: June 2024

AbstractThis paper presents enCloud, a new aspect‐oriented trusted service migration with SGX‐enabled cloud VM. Addressing the challenge of reconciling end‐to‐end security with VM migration, enCloud incorporates two key aspects: (1) end‐to‐end security for enclave context migration, and (2) VM abstraction for conventional VM context migration. This paper provides a practical guideline with applicable APIs for trusted service migration. In a case study, enCloud demonstrates effective trusted DB service migration on a cloud VM, achieving end‐to‐end security with minimal trust boundaries. The framework supports pre‐copy live VM migration to minimize service downtime. This paper contributes a concise and practical solution in the form of the enCloud framework for secure service migration.
Detection of Covid‐19 disease by using privacy‐aware artificial intelligence system
Authors: Ismetoglu Abdullah , Canbay Yavuz 
Published: June 2024

AbstractCovid‐19 is a highly infectious respiratory disease that spreads quickly between individuals and has been recognized as a pandemic by the World Health Organization (WHO). Chest x‐ray images, lung computed tomography images, and polymerase chain reaction tests are generally used to diagnose this disease by the doctors. Nevertheless, manual diagnosis of Covid‐19 disease is laborious and requires highly experienced professionals. Therefore, automated systems are always needed to assist doctors in their diagnostic decisions. In the field of medicine and healthcare, artificial intelligence and deep learning currently offer incredibly effective and rapid automatic decision‐support systems. Since sensitive data is used to diagnose Covid‐19, privacy has become a major concern in research that uses artificial intelligence and deep learning. In order to eliminate these issues, this paper proposes a novel deep learning model that privately detects Covid‐19 disease. The proposed model utilizes differential privacy technique to provide data privacy and convolutional neural network to diagnose Covid‐19 disease. The performance of the proposed model was evaluated through experiments conducted on five different datasets, resulting a maximum accuracy rate of 97%.
Unpacking Stimuli and Barriers to Internationalization Across Export Stages: The Case of Spanish Wine Firms in China
Authors: Jiménez‐Asenjo Noelia , Filipescu Diana A. , Curran Louise 
Published: June 2024

ABSTRACTFirm internationalization has been analyzed from different angles based on various theories. However, qualitative research on the stability of the factors that motivate and hinder internationalization across the export stages in emerging markets is limited. This study builds on the “stages” theories of internationalization, providing a detailed analysis of the perceived stability of stimuli and barriers during the exploration, entry, and expansion stages. We focus on a sample of Spanish wine firms exporting to China—a key wine market, with annual growth rates of over 25% between 2000 and 2020. The results suggest that the perception of most barriers is stage‐dependent, varying over time as commitment levels evolve. The main stimuli, on the other hand, remain constant across the different export stages. Moreover, we find that firm size, international experience, and access to local and international networks are key factors that influence the evolution of firms' internationalization in China, while lateral rigidity continues to constrain the expansion of smaller companies. These findings contribute to a deeper understanding of the opportunities and challenges of doing business in an emerging market, particularly in the institutional context in China, as well as their evolution over different stages of internationalization. Furthermore, they offer insights into the dynamics of the Chinese wine market and the implications for European exporters.
Unilateral retrobulbar haemorrhage in a cat secondary to suspected anticoagulant rodenticide intoxication
Authors: Seo Daeyun , Lim Seongsoo , Namgoong Beomkwan , Choe Ahreum , Uhm Heesung , Hong Hyeajeong , Lee Nanju , Kim Isong , Kim Min‐Su 
Published: June 2024

AbstractA 6‐month‐old intact female mixed‐breed kitten presented with severe exophthalmos of the left eye. Periocular lesions, including subconjunctival haemorrhage, third eyelid protrusion, and left eyelid oedema, were detected in the absence of globe retropulsion. The left intraocular pressure was increased, and ocular ultrasonography revealed ipsilateral retrobulbar fluid. Coagulation panels were markedly prolonged and severe anaemia was detected. Ultrasound‐guided retrobulbar centesis performed to decrease intraocular pressure yielded blood. Based on the history and clinical findings, anticoagulant rodenticide intoxication was suspected. Treatment included partial tarsorrhaphy and the administration of topical antibiotics, artificial tears, and vitamin K1. Fresh whole blood and fresh frozen plasma were transfused for supportive therapy. Coagulation parameters improved after 7 days of hospitalisation. The periocular lesions resolved within 14 days, despite persistent optic nerve damage and blindness. This case report raises the possibility that anticoagulant rodenticide toxicity may result in retrobulbar haemorrhage in the absence of other typical cavitary bleeding. Although uncommon, anticoagulant rodenticide toxicity should be considered in cats with retrobulbar haemorrhage.