bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memorialising Keats: Severn, Headstones and Hyperion
Authors: Scott Grant F. 
Published: June 2024

For obvious reasons, Keats's biographers have focused primarily on the last five months of the poet’s life and on the making of his reputation in the later nineteenth century. They have spent very little time, however, on the two uncertain years that followed the poet’s death when his legacy, largely in the hands of Brown, Taylor and Severn, hung in the balance. As Severn was recovering from Keats's death, he fought to establish his own livelihood as a painter and find an adequate means of memorialising his friend. He was preoccupied with two works of art, The Death of Alcibiades and the headstone for Keats's grave. I argue that these artworks represent complex expressions of Severn's grief and in this sense are both memorials, though Alcibiades disguises its aims in a conventional historical painting. In the strong reading of Hyperion embedded in the picture, Severn finds a way of coming to terms with the traumatic aftermath of Keats's death as well as the critical attacks on his poetry. My recent rediscovery of two key manuscript letters of this time by members of the Keats Circle lends support to the argument.
Development and validation of a prediction model for mortality in critically ill COVID-19 patients
Authors: Sun Xiaoxiao , Tang Jinxuan , Lu Jun , Zhang Hui , Li Cheng 
Published: June 2024

BackgroundEarly prediction of prognosis may help early treatment measures to reduce mortality in critically ill coronavirus disease (COVID-19) patients. The study aimed to develop a mortality prediction model for critically ill COVID-19 patients.MethodsThis retrospective study analyzed the clinical data of critically ill COVID-19 patients in an intensive care unit between April and June 2022. Propensity matching scores were used to reduce the effect of confounding factors. A predictive model was built using logistic regression analysis and visualized using a nomogram. Calibration and receiver operating characteristic (ROC) curves were used to estimate the accuracy and predictive value of the model. Decision curve analysis (DCA) was used to examine the value of the model for clinical interventions.ResultsIn total, 137 critically ill COVID-19 patients were enrolled; 84 survived, and 53 died. Univariate and multivariate logistic regression analyses revealed that aspartate aminotransferase (AST), creatinine, and myoglobin levels were independent prognostic factors. We constructed logistic regression prediction models using the seven least absolute shrinkage and selection operator regression-selected variables (hematocrit, red blood cell distribution width-standard deviation, procalcitonin, AST, creatinine, potassium, and myoglobin; Model 1) and three independent factor variables (Model 2). The calibration curves suggested that the actual predictions of the two models were similar to the ideal predictions. The ROC curve indicated that both models had good predictive power, and Model 1 had better predictive power than Model 2. The DCA results suggested that the model intervention was beneficial to patients and patients benefited more from Model 1 than from Model 2.ConclusionThe predictive model constructed using characteristic variables screened using LASSO regression can accurately predict the prognosis of critically ill COVID-19 patients. This model can assist clinicians in implementing early interventions. External validation by prospective large-sample studies is required.
RNA editing landscape of adipose tissue in polycystic ovary syndrome provides insight into the obesity-related immune responses
Authors: Chen Hanxiao , Li Tongtong , Gao Rui , Cheng Meng , Zhang Qiong , Liu Xiumei , Chen Mingli , Liao Xin , Qin Lang 
Published: June 2024

BackgroundPolycystic ovary syndrome (PCOS) is the most common reproductive–endocrine disorder with wide-ranging metabolic implications, including obesity. RNA editing, a post-transcriptional modification, can fine-tune protein function and introduce heterogeneity. However, the role of RNA editing and its impact on adipose tissue function in PCOS remain poorly understood.MethodsThis study aimed to comprehensively analyze RNA-editing events in abdominal and subcutaneous adipose tissue of PCOS patients and healthy controls using high-throughput whole-genome sequencing (WGS) and RNA sequencing.ResultsOur results revealed that PCOS patients exhibited more RNA-editing sites, with adenosine-to-inosine (A-to-I) editing being prevalent. The expression of ADAR genes, responsible for A-to-I editing, was also higher in PCOS. Aberrant RNA-editing sites in PCOS adipose tissue was enriched in immune responses, and interleukin-12 biosynthetic process. Tumor necrosis factor (TNF) signaling, nuclear factor kappa B (NF-κB) signaling, Notch signaling, terminal uridylyl transferase 4 (TUT4), hook microtubule tethering protein 3 (HOOK3), and forkhead box O1 (FOXO1) were identified to be of significant differences. Differentially expressed genes (DEGs) in PCOS adipose tissue were enriched in immune responses compared with controls, and the DEGs between subcutaneous and abdominal adipose tissue were also enriched in immune responses suggesting the important role of subcutaneous adipose tissue. Furthermore, we identified the correlations between RNA editing levels and RNA expression levels of specific genes, such as ataxia–telangiectasia mutated (ATM) and mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) in inflammation pathways and ATM, TUT4, and YTH N6-methyladenosine RNA-binding protein C2 (YTHDC2) in oocyte development pathway.ConclusionsThese findings suggest that RNA-editing dysregulation in PCOS adipose tissue may contribute to inflammatory dysregulations. Understanding the interplay between RNA editing and adipose tissue function may unveil potential therapeutic targets for PCOS management. However, further research and validation are required to fully elucidate the molecular mechanisms underlying these associations.
Effect of oral glucose tolerance test-based insulin resistance on embryo quality in women with/without polycystic ovary syndrome
Authors: Hu Zhengyan , Zeng Rujun , Tang Yuanting , Liao Yingjun , Li Tao , Qin Lang 
Published: June 2024

ObjectiveTo explore the effects of insulin resistance (IR) on embryo quality and pregnancy outcomes in women with or without polycystic ovary syndrome (PCOS) undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).MethodsA retrospective cohort study concerning patients with/without PCOS who received gonadotropin-releasing hormone (GnRH)-antagonist protocol for IVF/ICSI from January 2019 to July 2022 was conducted. All the patients included underwent oral glucose tolerance test plus the assessment of insulin release within 6 months before the controlled ovarian stimulation. The Matsuda Index was calculated to diagnose IR. Two populations (PCOS and non-PCOS) were included and each was divided into IR and non-IR groups and analyzed respectively. The primary outcome was the high-quality day 3 embryo rate.ResultsA total of 895 patients were included (751 with PCOS and 144 without PCOS). For patients with PCOS, the IR group had a lower high-quality day 3 embryo rate (36.8% vs. 39.7%, p=0.005) and available day 3 embryo rate (67.2% vs. 70.6%, p&lt;0.001). For patients without PCOS, there was no significant difference between the IR and non-IR groups in high-quality day 3 embryo rate (p=0.414) and available day 3 embryo rate (p=0.560). There was no significant difference in blastocyst outcomes and pregnancy outcomes for both populations.ConclusionBased on the diagnosis by the Matsuda Index, IR may adversely affect the day 3 embryo quality in patients with PCOS but not pregnancy outcomes. In women without PCOS, IR alone seems to have less significant adverse effects on embryo quality than in patients with PCOS. Better-designed studies are still needed to compare the differences statistically between PCOS and non-PCOS populations.
The association of composite dietary antioxidant index with periodontitis in NHANES 2009–2014
Authors: Meng Zihan , Zheng Wenzhuo , Meng Xiwei , Xu Hui 
Published: June 2024

BackgroundTo date, evidence is rare regarding whether and how dietary antioxidants are associated with the risk of periodontitis. This study aimed to investigate the association of composite dietary antioxidant index (CDAI) with periodontitis and tooth loss, using data from the National Health and Nutrition Examination Survey (2009–2014).MethodsA cross-sectional analysis was conducted using data from 10,067 adults aged ≥30 years who underwent assessments of periodontal health and the 1st day dietary recall. Based on a crude model and three adjusted models, multivariate regressions were used to examine the relationship between CDAI and periodontitis-related measurements including probing pocket depth, clinical attachment loss and tooth loss. Subgroup analyses and the restricted cubic splines plots were applied to examine the association between CDAI ingredients and periodontitis.ResultsFor the subjects with high CDAI scores, increased CDAI was associated with significant (P &lt; 0.05) reduction of severe periodontitis (odd ratio = 0.663, 95% confidence interval: 0.491–0.896) and increased number of remaining teeth (weighted β[SE] = 1.167[0.211]). However, the protective effect of CDAI on periodontitis vanished (P &gt; 0.05) in active smokers and former smokers. There were threshold levels for β-carotene, Vitamin A, C and E intakes where the risk of periodontitis significantly decreased (P &lt; 0.05) above these levels.ConclusionIncreased CDAI was associated with reduced risk of periodontitis and tooth loss for non-smokers. It was recommendable that proper dietary intakes of β-carotene, Vitamin A, C and E would be of benefit for preventive dental care and adjuvant therapies for periodontitis.
Associations between systemic inflammation indicators and nonalcoholic fatty liver disease: evidence from a prospective study
Authors: Gong Hao , He Qida , Zhu Lili , Feng Zhaolong , Sun Mengtong , Jiang Jingting , Yuan Xiaofeng , Shen Yueping , Di Jia 
Published: June 2024

BackgroundAlthough inflammation has been linked to nonalcoholic fatty liver disease (NAFLD), most studies have focused only on a single indicator, leading to inconsistent results. Therefore, a large prospective study that includes a variety of well-documented single and composite indicators of inflammation is needed. This study aimed to thoroughly investigate the potential associations between different systemic inflammatory indicators and NAFLD in the UK Biobank cohort.MethodsAfter excluding ineligible participants, 378,139 individuals were included in the study. Associations between systemic inflammatory indicators and hepatic steatosis were assessed using multivariate logistic regression. The relationships between systemic inflammatory indicators and nonalcoholic fatty liver disease were analysed using Cox proportional hazards models, and nonlinear associations were investigated using restricted cubic splines.ResultsAccording to the cross-sectional analysis, systemic inflammatory indicators significantly correlated with hepatic steatosis. Over a median follow-up of 13.9 years, 4,145 individuals developed NAFLD. After sufficient adjustment for confounding factors, CRP levels were found to be nonlinearly positively associated with NAFLD risk (P&lt;0.001), representing the strongest correlation among the tested relationships; lymphocyte count and the LMR showed an L-shaped correlation; monocyte count and neutrophil count showed a linear positive correlation (all P&lt; 0.001); and the NLR, PLR, and SII showed a U-shaped correlation (all P&lt;0.001).ConclusionsMultiple systemic inflammatory indicators are strongly associated with the development of NAFLD, and aggressive systemic inflammation management may have a favourable impact on reducing the burden of NAFLD; further randomized controlled studies are needed.
A single-center, retrospective study-spring-evaluating the efficacy and safety of recombinant human vascular endothelial inhibitor combined with anti-PD-1 in elderly patients aged 80 and above with NSCLC
Authors: Xing Tian , Gao Qianqian , Zhu Hongbin , Gao Jianrong , Yan Ganglin 
Published: June 2024

AimTo investigate the efficacy and safety of combining Recombinant Human Endostatin Injection (marketed as Endo) with anti-PD-1 in elderly patients aged 80 and above with non-small cell lung cancer (NSCLC).MethodsRetrospective analysis of 181 patients with NSCLC aged 80 and above treated in the Department of Respiratory and Critical Care Medicine at Chaohu Hospital, affiliated with Anhui Medical University, from June 2019 to January 2024. Patients who received at least one cycle of combined Endo with anti-PD-1 were included based on inclusion criteria. Clinical and pathological data were collected, including complete blood count, liver and kidney function, electrocardiogram, coagulation function, thyroid function, cardiac enzymes, and whole-body imaging. Adverse events were recorded with a final follow-up on January 25, 2024. The primary endpoints were progression-free survival (PFS) and overall survival (OS), with safety as a secondary endpoint.ResultsThis study involved 14 elderly patients with NSCLC aged over 80. Median progression-free survival (mPFS) was 102 days, and median overall survival (mOS) was 311 days. Subgroup analyses based on treatment cycles showed a non-significant 441-day mPFS increase in the long-term group (≥6 cycles, 5 patients) compared to the short-term group (&lt;6 cycles, 9 patients). However, the mOS in the long-term group significantly exceeded the short-term group by 141 days, with statistical significance (P=0.048). Further categorization revealed a 204-day shorter mPFS in the monotherapy maintenance group (Endo or Immunol) compared to the combination maintenance group (Endo combined with Immunol, 441 days). The mOS of the monotherapy maintenance group was longer (686 days) than the combination maintenance group (311 days), but no statistical significance (P= 0.710, 0.920). Throughout the treatment, 77 adverse events were recorded, mainly grade 1–2, with no new treatment-related reactions occurred. Overall, the safety of Endo combined with anti-PD-1 was considered good and manageable.ConclusionThe combination of Endo and anti-PD-1 could be an effective treatment choice for patients with NSCLC aged 80 and above.
Geochemical characteristics of the modern Yellow River Delta sediments and their response to evolution of the sedimentary environment
Authors: Meng Liwei , Wang Longsheng , Wang Qing , Zhao Jiawen , Zhang Guiye , Zhan Chao , Liu Xianbin , Cui Buli , Zeng Lin 
Published: June 2024

IntroductionSedimentary evolution and river channel changes of large river delta (e.g. Huang River, Changjiang River) in response to environmental changes have been one of the key issues in global change research.MethodsThis study reconstructed sedimentary environment changes in the modern Yellow River Delta (YRD), based on grain size and elemental chemical analysis of two short cores (YDC and YDG) from the southern region of the Qing 8 course delta of the modern YRD. ResultsThe results indicated that the cores YDC and YDG sediment were dominated by silt (58.47% and 67.6%, respectively) with varied grain-size variations and poor sediment sorting. The cores YDC and YDG sediments are both predominantly composed of the major element SiO2, and have an average content of 55.53% and 58.45%, respectively. The R-mode factor analysis showed the content of chemical substances of core sediments was controlled by three factors: grain size, sedimentary provenance, and marine sedimentary dynamics. DiscussionBefore the diversion of the Yellow River to the Qing 8 course in 1996, the two cores sediment were mainly sources from the Yellow River, and both cores were in the delta-front sedimentary environment under weak hydrodynamic conditions. After the Yellow River was diverted to the Qing 8 course, the cores YDC and YDG experienced significant erosion under the nearshore strong waves and tides. And then the sedimentary environment of the YRD changed from siltation to erosion. The results of the study would be helps to further our understanding of the changes in sediment grain size and geochemical element characteristics in the Yellow River estuary, and reveal the evolution of its sedimentary environment.
Uses of infrared thermography in acute illness: a systematic review
Authors: Stanley Sophie A. , Divall Pip , Thompson Jonathan P. , Charlton Matthew 
Published: June 2024

IntroductionInfrared thermography (IRT) is a non-contact, non-ionising imaging modality, providing a visual representation of temperature distribution across a surface.MethodsWe conducted a systematic search of indexed and grey literature for studies investigating IRT applications involving patients in acute care settings. Studies were categorised and described along themes identified iteratively using narrative synthesis. Quality appraisal of included studies was performed using the Quality Assessment tool for Diagnostic Accuracy Studies.ResultsOf 1,060 unique records, 30 studies were included. These were conducted in emergency departments and intensive care units involving adult, paediatric and neonatal patients. IRT was studied for the diagnosis, monitoring or risk stratification of a wide range of individual conditions. IRT was predominantly used to display thermal change associated with localised inflammation or microcirculatory dysfunction. Existing research is largely at an early developmental stage.DiscussionWe recommend that high quality diagnostic validation studies are now required for some clinical applications. IRT has the potential to be a valuable tool in the acute care setting and represents an important area for future research particularly when combined with advances in machine learning technology.Systematic review registrationCRD 42022327619 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=327619).
Clinical meaningfulness and psychometric robustness of the MG Symptoms PRO scales in clinical trials in adults with myasthenia gravis
Authors: Regnault Antoine , Habib Ali A. , Creel Kristin , Kaminski Henry J. , Morel Thomas 
Published: June 2024

ObjectivesThe objective of this research was to generate psychometric evidence supporting the myasthenia gravis (MG) symptoms patient-reported outcome (PRO) scales as a fit-for-purpose measure of severity of core symptoms of MG and provide information allowing their meaningful interpretation using data from a phase 3 study in MG.MethodsData from the MycarinG study, a phase 3 study of rozanolixizumab in patients with generalized MG who experience moderate to severe symptoms (ClinicalTrials.gov Identifier: NCT03971422) were analyzed with both classical test theory (CTT) and Rasch measurement theory (RMT). Meaningful within-individual change and group-level meaningful change were estimated for three MG Symptoms PRO scales using anchor- and distribution-based methods. Anchor-based methods used patient global impression of severity (PGIS) and change (PGIC) in MG symptoms as anchors.ResultsGood measurement properties of the MG Symptoms PRO scales were shown in the sample of 200 participants: good to excellent reliability (test–retest and internal consistency reliability) and validity (associations between items and scores within the MG Symptoms PRO scales and between the MG Symptoms PRO scores and other clinical outcomes—MG ADL, QMG score, MGC score, and MGFA classes—were as expected); and the items showed good coverage of the continuum and fit to the Rasch model. Triangulation of the anchor- and distribution-based method results led to the definition of clinically meaningful within-patient improvement in scores for Muscle Weakness Fatigability (−16.67), Physical Fatigue (−20.00), and Bulbar Muscle Weakness (−20.00), with associated ranges. Benchmarks are also proposed for the interpretation of group-level results.ConclusionThe strong psychometric performance of the MG Symptoms PRO scales and the information generated to guide its interpretation supports its use in clinical trials for demonstrating the clinical benefits of new treatments targeting core symptoms of MG (muscle weakness fatigability, physical fatigue, bulbar muscle weakness, respiratory muscle weakness, and ocular muscle weakness).
Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy
Authors: Pfender Nikolai , Jutzeler Catherine R. , Hubli Michèle , Scheuren Paulina S. , Pfyffer Dario , Zipser Carl M. , Rosner Jan , Friedl Susanne , Sutter Reto , Spirig José M. , Betz Michael , Schubert Martin , Seif Maryam , Freund Patrick , Farshad Mazda , Curt Armin , Hupp Markus 
Published: June 2024

IntroductionNew diagnostic techniques are a substantial research focus in degenerative cervical myelopathy (DCM). This cross-sectional study determined the significance of cardiac-related spinal cord motion and the extent of spinal stenosis as indicators of mechanical strain on the cord.MethodsEighty-four DCM patients underwent MRI/clinical assessments and were classified as MRI+ [T2-weighted (T2w) hyperintense lesion in MRI] or MRI− (no T2w-hyperintense lesion). Cord motion (displacement assessed by phase-contrast MRI) and spinal stenosis [adapted spinal canal occupation ratio (aSCOR)] were related to neurological (sensory/motor) and neurophysiological readouts [contact heat evoked potentials (CHEPs)] by receiver operating characteristic (ROC) analysis.ResultsMRI+ patients (N = 31; 36.9%) were more impaired compared to MRI− patients (N = 53; 63.1%) based on the modified Japanese Orthopedic Association (mJOA) subscores for upper {MRI+ [median (Interquartile range)]: 4 (4–5); MRI−: 5 (5–5); p &lt; 0.01} and lower extremity [MRI+: 6 (6–7); MRI−: 7 (6–7); p = 0.03] motor dysfunction and the monofilament score [MRI+: 21 (18–23); MRI−: 24 (22-24); p &lt; 0.01]. Both patient groups showed similar extent of cord motion and stenosis. Only in the MRI− group displacement identified patients with pathologic assessments [trunk/lower extremity pin prick score (T/LEPP): AUC = 0.67, p = 0.03; CHEPs: AUC = 0.73, p = 0.01]. Cord motion thresholds: T/LEPP: 1.67 mm (sensitivity 84.6%, specificity 52.5%); CHEPs: 1.96 mm (sensitivity 83.3%, specificity 65.6%). The aSCOR failed to show any relation to the clinical assessments.DiscussionThese findings affirm cord motion measurements as a promising additional biomarker to improve the clinical workup and to enable timely surgical treatment particularly in MRI− DCM patients.Clinical trial registrationwww.clinicaltrials.gov, NCT 02170155.