bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the need for an arterial resection a contraindication to pancreatic resection for locally advanced pancreatic adenocarcinoma? a case‐matched controlled study
Authors: Bachellier Philippe , Rosso Edoardo , Lucescu Ionut , Oussoultzoglou Elie , Tracey Jacky , Pessaux Patrick , Ferreira Nelio , Jaeck Daniel 
Published: November 2010

AbstractBackground and ObjectivesArterial resection (AR) has traditionally been considered as a contraindication to pancreatic resection for locally advanced pancreatic adenocarcinoma. The objective was to evaluate if pancreatic resection with AR was worthwhile.MethodsBetween January 1990 and December 2008 the records of 26 consecutive patients who underwent a curative‐intent pancreatic resection for adenocarcinoma of the pancreas with AR (AR+ group) were matched 1:1 to those of the whole series of pancreatic resection performed in our institution. The final study population (n = 52) included two groups of patients: the study group AR+ = 26 and the control group AR− = 26.ResultsThe 1‐ and 3‐year survival rates were similar in the two groups (65.9% and 22.1%, median 17 months for the group AR + , versus 50.0% and 17.6%, median 12 months, for the group AR−; P = 0.581). The multivariate analysis showed that: arterial wall invasion at the site of AR, the total number of resected lymph nodes of ≤15, and perineural invasion were independent prognostic factors for survival.ConclusionPancreatic resections with AR for adenocarcinoma allowed to obtain a 3‐survival rate similar to that of a matched group of patients not requiring AR. J. Surg. Oncol. 2011;103:75–84. © 2010 Wiley‐Liss, Inc.
Methanol exposure does not lead to accumulation of oxidative DNA damage in bone marrow and spleen of mice, rabbits or primates
Authors: McCallum Gordon P. , Siu Michelle , Ondovcik Stephanie L. , Sweeting J. Nicole , Wells Peter G. 
Published: November 2010

AbstractGenotoxicity tests indicate methanol (MeOH) is not mutagenic, but a rodent study has suggested carcinogenic potential, which could result from free radical‐initiated oxidative DNA damage. To investigate this possibility we treated male CD‐1 mice, New Zealand white rabbits, and cynomolgus monkeys with MeOH (2.0 g/kg ip) and assessed tissue oxidative DNA damage 6 h post‐dose, measured as 8‐hydroxy‐2′‐deoxyguanosine (8‐oxodG). We found no MeOH‐dependent increases in 8‐oxodG in bone marrow or spleen of any species. Chronic treatment of CD‐1 mice with MeOH (2.0 g/kg ip) daily for 15 d also did not increase 8‐oxodG levels in these organs. Further studies in the DNA repair deficient oxoguanine glycosylase 1 (Ogg1) knockout (KO) mice supported these findings. Fibroblasts fromOgg1KO mice accumulated 8‐oxodG following acute exposure to the renal carcinogen potassium bromate (KBrO3; 2.0 mM) but did not accumulate 8‐oxodG following exposure to 125 mM MeOH 6 h post‐treatment.Ogg1KO mice accumulated 8‐oxodG in bone marrow and spleen with age but not following exposure to MeOH. In addition, free radical‐mediated hydroxynonenal‐histidine protein adducts were not enhanced by MeOH in primate bone marrow or spleen, or in rabbit bone marrow or mouse spleen, although modest increases were observed in rabbit spleen and mouse bone marrow. Taken together these observations suggest that MeOH exposure does not promote the accumulation of oxidative DNA damage in bone marrow and spleen, and it is unlikely that human environmental exposure to MeOH would lead to lymphomas via this mechanism. Mol. Carcinog. © 2010 Wiley‐Liss, Inc.
Ah receptor antagonism inhibits constitutive and cytokine inducible IL6 production in head and neck tumor cell lines
Authors: DiNatale Brett C. , Schroeder Jennifer C. , Perdew Gary H. 
Published: November 2010

AbstractThere is increasing evidence that the aryl hydrocarbon receptor (AHR) plays a role in tumor progression through numerous mechanisms. We have previously shown that, in certain cancer cell lines that are typically nonresponsive to cytokine‐mediated IL6 induction, activation of the AHR with the agonist 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin derepresses the IL6 promoter and allows for synergistic induction following IL1β treatment. The mechanism by which this occurs involves liganded AHR binding upstream from the transcription start site and dismissing HDAC‐containing corepressor complexes, giving rise to a promoter structure that is more amenable to NF‐κB activation. This fact, combined with observations of multiple endogenously produced chemicals activating the AHR, led us to study its role in basal expression among high cytokine‐producing cancer cell lines. The current study provides evidence that several head and neck squamous cell carcinoma cell lines have a level of constitutively bound AHR at the IL6 promoter, allowing for higher basal and readily inducible IL6 transcription. Treatment of these cell lines with an AHR antagonist led to dismissal of the AHR from the IL6 promoter and recruitment of corepressor complexes, thus diminishing cytokine expression. Head and neck squamous cell carcinoma is typically a high cytokine‐producing tumor type, with IL6 expression levels correlating with disease aggressiveness. For this reason, AHR antagonist treatment could represent a novel adjuvant therapy for patients, lowering pro‐growth and antiapoptotic signaling with minimal systemic side effects. Mol. Carcinog. © 2010 Wiley‐Liss, Inc.
Critical evaluation of folate data in European and international databases: Recommendations for standardization in international nutritional studies
Authors: Bouckaert Kimberley P. , Slimani Nadia , Nicolas Geneviève , Vignat Jérôme , Wright Anthony J. A. , Roe Mark , Witthöft Cornelia M. , Finglas Paul M. 
Published: November 2010

AbstractScope: The objective was to perform an inventory and critical evaluation of folate data in selected European and international databases. The ultimate aim was to establish guidelines for compiling standardized folate databases for international nutritional studies.Methods and results: An ad hoc questionnaire was prepared to critically compare and evaluate folate data completeness, quantification, terminologies, and documentation of 18 European and international databases, and national fortification regulations. Selected countries participated in the European Prospective Investigation into Nutrition and Cancer project and European Food Information Resource Network (EuroFIR). Folate completeness was generally high. “Total folate” was the most common terminology and microbiological assay was the most frequently reported quantification method. There is a lack of comparability within and between databases due to a lack of value documentation, the use of generic or non‐appropriate terminologies, folate value conversions, and/or lack of identification of synthetic folic acid.Conclusion: Full value documentation and the use of EuroFIR component identifiers and/or INFOODS tagnames for total folate (“FOL”) and synthetic folic acid (“FOLAC”), with the additional use of individual folates, will increase comparability between databases. For now, the standardized microbiological assay for total folate and HPLC for synthetic folic acid are the recommended quantification methods.
The impact of pre‐ and/or probiotics on human colonic metabolism: Does it affect human health?
Authors: De Preter Vicky , Hamer Henrike M , Windey Karen , Verbeke Kristin 
Published: November 2010

AbstractSince many years, the role of the colonic microbiota in maintaining the host's overall health and well‐being has been recognized. Dietary modulation of the microbiota composition and activity has been achieved by the use of pre‐, pro‐ and synbiotics. In this review, we will summarize the available evidence on the modification of bacterial metabolism by dietary intervention with pre‐, pro‐ and synbiotics. Enhanced production of SCFA as a marker of increased saccharolytic fermentation is well documented in animal andin vitrostudies. Decreased production of potentially toxic protein fermentation metabolites, such as sulfides, phenolic and indolic compounds, has been less frequently demonstrated. Besides, pre‐, pro‐ and synbiotics also affect other metabolic pathways such as the deconjugation of secondary bile acids, bacterial enzyme activities and mineral absorption. Data from human studies are less conclusive. The emergence of new analytical techniques such as metabolite profiling has revealed new pathways affected by dietary intervention. However, an important challenge for current and future research is to relate changes in bacterial metabolism to concrete health benefits. Potential targets and expected benefits have been identified: reduced risk for the metabolic syndrome and prevention of colorectal cancer.
Multiscale modeling of a sensitive marine clay
Authors: Yin Zhen‐Yu , Hattab Mahdia , Hicher Pierre‐Yves 
Published: November 2010

AbstractThis paper examines the mechanical behavior of a sensitive marine clay. Various laboratory tests on intact and reconstituted samples of Guinea Gulf marine clay were performed under isotropic compression and drained triaxial compression at constant confining stresses. Microstructure analysis on intact and reconstituted samples was also carried out under different loading conditions. The effect of inter‐aggregates bonding on mechanical properties is discussed. Based on experimental analysis, a new modeling method is proposed. In this approach, the clay is regarded as an assembly of aggregates of clay particles. An inter‐aggregate contact law is introduced relating contact forces to aggregates relative displacements. The deformation of the assembly can be obtained by integrating the movement of the inter‐aggregate contacts in all orientations. Thus, the effect of inter‐aggregates bonds and debonding is considered in a direct way. The model is evaluated through comparisons between the predicted and measured results on Guinea Gulf marine clay. The evolutions of local stresses, strains, and bonds in inter‐aggregates planes are discussed to explain the anisotropy induced by the applied loading. Copyright © 2010 John Wiley & Sons, Ltd.
Transplant‐associated thrombotic microangiopathy in pediatric patients treated with sirolimus and tacrolimus
Authors: Rosenthal Joseph , Pawlowska Anna , Bolotin Ellen , Cervantes Cheryl , Maroongroge Sean , Thomas Sandra H. , Forman Stephen J. 
Published: November 2010

AbstractBackgroundTransplant‐associated thrombotic microangiopathy (TMA) syndromes are reported to occur with increased frequency in transplant patients treated with siroliumus combined with a calcineurin inhibitor. We performed a retrospective study of all pediatric transplant patients at City of Hope who were administered combined tacrolimus/sirolimus (TAC/SIR) to determine the occurrence of TMA.ProcedureThis analysis includes 41 consecutive patients between the ages of 2 and 20 (median age 9.1) who received an allogeneic hematopoietic stem cell transplant from any source and also received TAC/SIR for prevention or treatment of GVHD. Of those 41 patients, 20 received TAC/SIR as GVHD prohpylaxis and were designated the preventative group (PG), while 21 received TAC/SIR as treatment for GVHD and were designated the therapy group (TG). TMA occurrence in both groups was documented from day −1 of transplant to day 60 for the PG, and until 30 days after last dose for the TG. TMA was defined according to 2005 consensus criteria.ResultsFive of twenty patients in the PG, and five of twenty one in the TG, experienced TMA, with an overall rate of 23.8% for the population. All ten patients with TMA showed elevated levels of TAC, SIR or both and nine of ten suffered from organ injury due to regimen‐related toxicity or GVHD.ConclusionPhysicians should exercise caution in the use of TAC/SIR in pediatric patients due to a high rate of TMA. It is not recommended for heavily pre‐treated patients and peak levels of TAC/SIR must be very carefully controlled. Pediatr Blood Cancer 2011;57:142–146. © 2010 Wiley‐Liss, Inc.
The NSN link as electron accepting moiety for stable, solution‐processable conjugated oligomers
Authors: Wang Mingfeng , Sun Yanming , Tong Minghong , Chesnut Eneida S. , Seo Jung Hua , Kumar Rajeev , Wudl Fred 
Published: November 2010

AbstractNew conjugated oligomers, oligo(9,9‐didodecylfluorene‐bis‐sulphurdiimide), consisting of 9,9‐didodecylfluorene separated by NSN moieties, are reported. These oligomers are stable purple solids under ambient conditions with absorption covering a broad spectral window in the UV‐vis range and a main broad peak centered at 555 nm with onset extending to 700 nm. These oligomers show an obviously longer conjugation length than its dimeric analogue, bis‐9,9‐didodecyl‐fluorene‐2‐sulfurdiimide that shows a band‐edge absorption centered at 484 nm with onset at 590 nm. The dimer and oligomers are soluble in a variety of organic solvents. Moreover, we found that the oligomer with an average repeating‐unit number of six could significantly quench the photoluminescence (PL) of poly[2‐methoxy‐5‐(2′‐ethyl‐hexyloxy)‐1,4‐phenylene vinylene] (MEH‐PPV) or poly(3‐hexylthiophene) (P3HT) in the solid state. More importantly, the composites of this oligomer with P3HT showed a nearly 10‐fold enhancement of the photocurrent, compared with that of P3HT itself. In addition, the PL of this oligomer could be quenched by the presence of phenyl‐C61‐butyric acid methyl ester (PCBM) in toluene. These results suggest the presence of photoinduced charge transfer in composites of these oligomers blended with an electronic partner that either donates or accepts electrons. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Synthesis and properties of multiblock copoly(arylene ether)s containing superacid groups for fuel cell membranes
Authors: Mikami Takefumi , Miyatake Kenji , Watanabe Masahiro 
Published: November 2010

AbstractA series of block copoly(arylene ether)s containing pendant superacid groups were synthesized, and their properties were investigated for fuel cell applications. Two series of telechelic oligomers, iodo‐substituted oligo(arylene ether ketone)s and oligo(arylene ether sulfone)s, were synthesized. The degree of oligomerization and the end groups were controlled by changing the feed ratio of the monomers. The nucleophilic substitution polymerization of the two oligomers provided iodo‐substituted precursor block copolymers. The iodo groups were converted to perfluorosulfonic acid groups via the Ullmann coupling reaction. The high degree of perfluorosulfonation (up to 83%) was achieved by optimizing the reaction conditions. Tough and bendable membranes were prepared by solution casting. The ionomer membranes exhibited characteristic hydrophilic/hydrophobic phase separation with large hydrophilic clusters (ca. 10 nm), which were different from that of our previous random copolymers with similar molecular structure. The block copolymer structure was found to be effective in improving the proton‐conducting behavior of the superacid‐modified poly(arylene ether) ionomer membranes without increasing the ion exchange capacity (IEC). The highest proton conductivity was 0.13 S/cm at 80 °C, 90% relative humidity, for the block copolymer ionomer membrane with IEC = 1.29 mequiv/g. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011
Polymers for neural implants
Authors: Hassler Christina , Boretius Tim , Stieglitz Thomas 
Published: November 2010

AbstractNeural implants are technical systems that restore sensory or motor functions after injury and modulate neural behavior in neuronal diseases. Neural interfaces or prostheses have lead to new therapeutic options and rehabilitation approaches in the last 40 years. The interface between the nervous tissue and the technical material is the place that determines success or failure of the neural implant. Recording of nerve signals and stimulation of nerve cells take place at this neuro‐technical interface. Polymers are the most common material class for substrate and insulation materials in combination with metals for interconnection wires and electrode sites. This work focuses on the neuro‐technical interface and summarizes its fundamental specifications first. The most common polymer materials are presented and described in detail. We conclude with an overview of the different applications and their specific designs with the accompanying manufacturing processes from precision mechanics, laser structuring and micromachining that are introduced in either the peripheral or central nervous system. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2010
Progress in low‐loss and high‐bandwidth plastic optical fibers
Authors: Koike Yasuhiro , Koike Kotaro 
Published: November 2010

AbstractPlastic optical fibers (POFs) are highly promising transmission media for future home networking.In comparison to glass optical fibers (GOFs), which are commonly used in core and metropolitan networks, POFs offer many advantages such as great flexibility and easy handling. This review begins with the basic concepts of optical fibers and moves on to the early history of loss reduction in POFs. What drastically changed the status of POFs in the communications field was a graded‐index technology that improved the bandwidth to over 1 gigabits per second. However, even after the loss and bandwidth were enhanced to their limits, the performances of POFs were insufficient for market demand when using conventional optical polymer materials such as poly(methyl methacrylate). Recently, this problem has been solved by several lines of material research using fluorinated polymers. As a result, high‐speed optical home networking by POFs has become more realistic. © 2010 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2011
Risk factors for current wheezing and its phenotypes among elementary school children
Authors: Civelek Ersoy , Cakir Banu , Orhan Fazıl , Yuksel Hasan , Boz Aysen B. , Uner Abdurrahman , Sekerel Bulent E. 
Published: November 2010

AbstractBackgroundAccumulating evidence suggests, asthma includes many phenotypes with varying clinical and prognostic features. Epidemiological surveys documented a number of environmental risk factors for the development of asthma and interestingly these differ between and within countries, suggesting that the differences may be related with the different distribution of asthma phenotypes. This study aimed to investigate risk factors of current wheezing (CW) and different wheezing phenotypes in elementary school children.MethodsSix thousand nine hundred sixty‐three 9‐ to 11‐year‐old children of a previous multicenter survey where the methodology of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase‐II was used were analyzed. Wheezing phenotypes were defined as wheezing with rhinitis (RW), wheezing with rhinoconjunctivitis (RCW), atopic wheezing (AW), non‐atopic wheezing (NAW), and frequent wheezing (FW) (≥4/year wheezing episodes).ResultsThe prevalence of CW was 15.8% and among these, 22.4%, 67.3%, 45.9%, 20.5%, and 79.5% were classified as FW, RW, RCW, AW, and NAW, respectively. History of parental asthma/allergic rhinitis, coexistence of other allergic diseases, presence of mold and dampness in the house lived during the first year of life and maternal smoking in pregnancy were found to be risk factors for most phenotypes (odds ratio (OR) ranged from 1.43 to 3.56). Number of household in the last year (OR = 1.14), prematurity (OR = 2.08), and duration of breastfeeding (OR = 1.02) per additional month were found to be risk factor for FW, AW, and RCW, respectively.ConclusionBeside common risk factors for the development of asthma and its phenotypes, certain risk factors appeared to play a role in the development of phenotypic characteristics of asthma. These findings support our hypothesis that each phenotype has not only different clinical characteristics but also has different roots. Pediatr. Pulmonol. 2011; 46:166–174. © 2011 Wiley‐Liss, Inc.
Respiratory syncytial virus prevention and therapy: Past, present, and future
Authors: Wright Melvin , Piedimonte Giovanni 
Published: November 2010

AbstractRespiratory syncytial virus (RSV) is the most common respiratory pathogen in infants and young children worldwide. More than 50 years after its discovery, and despite relentless attempts to identify pharmacological therapies to improve the clinical course and outcomes of this disease, the most effective therapy remains supportive care. Although the quest for a safe and effective vaccine remains unsuccessful, pediatricians practicing during the past decade have been able to protect at least the more vulnerable patients with safe and effective passive prophylaxis. This review summarizes the history, microbiology, epidemiology, pathophysiology, and clinical manifestations of this infection in order to provide the reader with the background information necessary to fully appreciate the many challenges presented by the clinical management of young children with bronchiolitis. The last part of this article attempts an evidence‐based review of the pharmacologic strategies currently available and those being evaluated, intentionally omitting highly experimental approaches not yet tested in clinical trials and, therefore, not likely to become available in the foreseeable future. Pediatr Pulmonol. 2011; 46:324–347. © 2010 Wiley‐Liss, Inc.
The action of fish peptide Orpotrin analogs on microcirculation
Authors: Conceição Katia , Bruni Fernanda Miriane , Santos Juliane M. , Lopes Robson Melo , Marques Elineide E. , Fernandez Jorge H. , Lopes‐Ferreira Mônica 
Published: November 2010

AbstractIn order to investigate the relationship between the primary structure of Orpotrin, a vasoactive peptide previously isolated from the freshwater stingray Potamotrygon gr. orbignyi, and its microcirculatory effects, three Orpotrin analogs were synthesized. The analogs have a truncated N‐terminal with a His residue deletion and two substituted amino acid residues, where one Nle is substituted for one internal Lys residue and the third analog has a substitution of a Pro for an Ala (Orp‐desH1, Orp‐Nle and Orp‐Pro/Ala, respectively). Only Orp‐desH1 could induce a lower vasoconstriction effect compared with the natural Orpotrin, indicating that besides the N‐terminal, the positive charge of Lys and the Pro residues located at the center of the amino acid chain is crucial for this vasoconstriction effect. Importantly, the suggestions made with bioactive peptides were based on the molecular modeling and dynamics of peptides, the presence of key amino acids and shared activity in microcirculation, characterized by intravital microscopy. Moreover, this study has demonstrated that even subtle changes in the primary structure of Orpotrin alter the biological effects of this native peptide significantly, which could be of interest for biotechnological applications. Copyright © 2010 European Peptide Society and John Wiley & Sons, Ltd.
Effect of UV radiation on the reactivity of porous methyl‐doped SiO2 layers
Authors: Dultsev Fedor N. 
Published: November 2010

AbstractThe effect of plasma treatment on the chemical reactivity of the surface of porous layers based on methyl‐doped silicon dioxide is considered. A principal difference between the effects of plasma on materials with the pores of different sizes is demonstrated. It is shown that the VUV irradiation passivates the surface of the layers with smaller pores (1.1 nm in radius), while the films with larger pores (5.5 nm) do not get passivated (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)