bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can CBC Profile and Liver Function Test Predict Chronic Kidney Disease among a Normal population?
Authors: Moosazadeh Mahmood , Espahbodi Fatemeh , Afshari Mahdi , Eslami Arman 
Published: May 2024

Background:
Kidney disorders are mainly diagnosed after a major decline in the renal function. Chronic kidney disease (CKD) is one of the most common disorders of the urinary system defined by gradual reduction of renal function. Considering the silent nature and late diagnosis of this problem, this study aims to investigate the prevalence of CKD and its association with Complete Blood Count (CBC) profile and liver function tests.

Methods:
Out of the total population enrolled in the Tabari cohort study, 5822 subjects without history of diabetes mellitus, hypertension, cardiac disease, renal failure, cancer, and pathologic obesity were selected. Glomerular filtration rate (GFR) was calculated using creatinine clearance as well as Modification of Diet in Renal Disease (MDRD) equation. CKD was defined as GFR decline less than 60 ml/min/1.73 m2 regardless of its main cause.

Results:
Prevalence of CKD in total population as well as men and women was 20.2%, 16.8%, and 23.1%, respectively. Multivariate models showed the odds ratios for third and fourth quartiles of Mean corpuscular volume (MCV) and also for the fourth quartile of the lymphocyte count as of 0.78 (0.64, 0.95), 0.81 (0.67, 0.99), and 1.22 (1.01, 1.47), respectively. Corresponding odds ratios for the fourth, third, and second quartiles of Blood Urea Nitrogen (BUN) were 1.42 (1.14, 1.77), 1.76 (1.42, 2.19), and 2.79 (2.27, 3.43), respectively.

Conclusions:
This study showed a high prevalence of CKD among the normal residents (without major underlying diseases and excessive obesity) in the north of Iran, especially among women. In addition, low MCV, low lymphocyte, and high BUN were detected as predictors of this disorder.
Investigation of Intrathoracic Morphology in Computed Tomography Images of Individuals with Anterior Chest Wall Deformity
Authors: Ozturk Mustafa , Ulger Harun , Ozsoy Ibrahim Ethem , Tezcan Mehmet Akif , Savranlar Ahmet 
Published: May 2024

Abstract

Objective:
Morphological determination of the location, position, and level of the intrathoracic organs in relation to the thoracic vertebrae of individuals with anterior chest wall deformity using computed tomography (CT) images.

Study Design:
Retrospective study.

Place and Duration of Study:
Kayseri Health Practice and Research Center, University of Health Sciences Turkey, Kayseri, Turkey, January 2020–January 2022.

Subjects and Methods:
In the study, clinical and morphological measurements of intrathoracic organs were performed on thorax CT images of 80 patients with pectus excavatum (PE) and 70 pectus carinatum (PC) diagnose.

Results:
The mean Haller index (HI) of patients with PE was measured at the highest T11 (Female: 3.79 cm, Male: 3.67 cm) and lowest at T7 (Female: 3.41 cm, Male: 3 cm). The mean HI at all levels (T5-T11) was higher than healthy individuals (P < 0.05). PE severity was higher in women than men. Due to the increase in the severity of PE, it was determined that the heart was displaced in the left anterior, left posterior and downward directions, and the cardiothoracic ratio (CTR) increased. In severe cases, it was seen that the aorta was located on the left side of the corpus vertebrae in the left posterior region. In patients with PC, the most severe HI value was measured at the T7 level (1.54 cm) in women and at the T9 level (1.42 cm) in men. There was no significant difference between the CTRs of patients with PC and healthy individuals.

Conclusion:
We think that knowing the location, position, and levels of the organs in cases with anterior chest wall deformity will shed light on clinical studies.
Morphologic and Morphometric Evaluation of Nutrient Foramina of Tibia
Authors: Ülkir Mehmet , Karaçoban Levend , Günes Burcu Erçakmak 
Published: May 2024

Abstract

Introduction:
The aim of this study is to investigate the morphologic and morphometric characteristics of nutrient foramina on dry tibia bones, as well as the clinical implications.

Materials and Methods:
This study involved 63 tibiae (28 right and 35 left). The length of the tibia, number, direction, size, and location of nutrient foramina in relation to borders, surfaces, and soleal line, the distance between the nutrient foramina and proximal tibial end, the mediolateral, anteroposterior diameter of the tibial shaft at the level of the nutrient foramina, and the foraminal and cnemicus indexes were evaluated. The size of the nutrient foramina was classified using hypodermic needles of 14-16-18-20-22-24 gauge. Nutrient foramina with gauge sizes of 14–16, 18–20, and 22–24 were classified as large, medium, and small, respectively.

Results:
On the tibia, there is usually one nutrient foramina (92.06%), which may locate on the posterior surface (91.18%), lateral to the soleal line (95.17%), and in the upper 1/3 of the tibia (80.9%). The nutrient foramina was primarily 18–20 gauge (72.05%) and directed downward.

Discussion and Conclusion:
The morphological and morphometric features of nutrition foramina are vital to know, especially in surgical procedures and fractures of the upper 1/3 of the tibia. The sizes of NFs were evaluated detail in this study, and it was found that shorter tibiae had smaller NFs that were located more proximal than medium and large NFs. This morphological feature was described in the literature for the first time.
Sexual and Continence Rehabilitation after Radical Prostatectomy
Authors: Aggarwal Amit , Cahill Declan , Jena Rahul 
Published: May 2024

Summary
Incontinence and Erectile-Dysfunction (ED) is a reality for many men post-Radical Prostatectomy. Urologists undertaking this procedure should prioritize minimizing postoperative incontinence and sexual dysfunctions. One major obstacle in the rehabilitation process is the lack of a standardized, objective, universal definition to accurately define post-operative incontinence and ED. This makes it challenging to tailor treatment, manage expectations, and also monitor progress in patients who suffer from post-RP incontinence and ED. Nevertheless, treatment always remains undoubtedly superior to leaving the issues without intervention. This chapter describes in details about the complete rehabilitation process to be followed in each and every patient undergoing Radical Prostatectomy.
Future Landscape in High-risk Prostate Cancer and Metastatic Prostate Cancer
Authors: Garg Harshit , Kaushik Dharam , Liss Michael Andre 
Published: May 2024

Summary
The management of high-risk and advanced prostate cancer had a major paradigm shift over the past decade. From the Huggins’ era of sole androgen deprivation therapy (ADT), the management has evolved to novel androgen receptor signaling inhibitors (ARSI), chemotherapy, targeted molecular, immunotherapy, and radiotheranostics. The management of advanced prostate cancer is broadly studied under metastatic hormone or castration-sensitive prostate cancer (mCSPC) or metastatic castration-resistant prostate cancer (mCRPC). The mCSPC has evolved from mere ADT to the use of abiraterone, enzalutamide, and docetaxel-based chemotherapy and the burning conflict of treatment intensification with triplet therapy. Various novel agents, such as poly (ADP-ribose) polymerase inhibitors (PARPIs) and radiotheranostics, are being explored in the management of mCSPC. The management of mCRPC has evolved from mitoxantrone to docetaxel-based therapy, novel ARSI therapy, PARPI, 177 lutetium-prostate-specific membrane antigen-617, or novel-targeted therapy.
Pathology of Prostate Cancer: What Urologist Should Know and Future Directions
Authors: Singh Nikhil , Rane Swapnil , Menon Santosh 
Published: May 2024

Summary
Prostate cancer is the second-most common malignancy in men. Risk factors include age, family history, and genetic predisposition. Gleason grading remains one of the strongest prognostic factors in prostate cancer which has been modified multiple times with the most recent modifications brought in ISUP 2019 consensus conference and by GUPS. This chapter aims to familiarize the urologist with the nuances of pathology reporting, especially the Gleason scoring system in a simplified manner with some practical updates. It also brings forth the latest upcoming trends in areas of the utility of artificial intelligence in the field of prostate pathology.
Artificial Intelligence Applications in Prostate Cancer Management: Success Stories and Future Ahead
Authors: Khanna Raghav , Martinez Alejandro Granados , Raison Nicholas , Ourselin Sebastien , Briganti Alberto , Montorsi Francesco , Dasgupta Prokar 
Published: May 2024

Summary
This review summarizes and provides an outlook for developments around the use of artificial intelligence (AI) in the diagnosis and treatment of prostate cancer. We searched existing literature on the design and development of new AI-based systems using a non-systematic approach. Areas targeted by AI include the diagnosis, Gleason scoring, biomarker identification, and prognosis of prostate cancer (PCa) from digitised histopathology, segmentation, detection, and classification of PCa from magnetic resonance imaging, AI applications for prostate ultrasound, AI in radiotherapy for PCa including synthetic computed tomography generation and treatment planning and AI in measuring and improving surgical outcomes and education. Recent work has focused on deep learning techniques. Algorithms have achieved results that outperform or are similar to those of experts. However, few proposed algorithms are clinically oriented and can be practically deployed. Future progress needs to be made in data availability, prospective evaluation, regulation, responsible AI, explainability, and practical aspects of clinical deployment.
Moment analysis on channel eigenvalue for DAS‐to‐DAS system
Authors: Gwak Donghyuk , Jeon Youngil , Lee Jemin , Na Jee‐Hyeon 
Published: May 2024

AbstractIn this paper, we study on channel eigenvalue distribution of MIMO system, namely, DAS‐to‐DAS system, of which transmit and receive nodes are geometrically distributed in unplanned manner. It offers key to performance upper bound analysis of collaborative transmission in unplanned network and multi‐user transmission of distributed antenna system. Previous studies on stochastic geometry have analyzed performance of single typical receiver, while transmitters are geometrically distributed. And random matrix theory has unveiled probabilistic behavior of MIMO channel eigenvalues, while transmit and receive antennas are collocated. Our study integrates knowledge from the two different research fields to extend the applicability to analysis on channel eigenvalue distribution of DAS‐to‐DAS system. As a preliminary research on such channel eigenvalue distribution, its first few moments are derived in analytic form. And its coherency of the analysis results with Monte‐Carlo simulation results has examined.
IgG, IgM, and Nonstructural Protein 1 Response Profiles after Receipt of Tetravalent Dengue Vaccine TAK-003 in a Phase 2 Randomized Controlled Trial
Authors: Low Jenny G. , Oh Helen M. , Leo Yee-Sin , Kalimuddin Shirin , Wijaya Limin , Pang Junxiong , Lee Tau Hong , Moss Kelley J. , Brose Manja , Tricou Vianney 
Published: May 2024

ABSTRACT.
The profiles of vaccine-induced dengue antibodies may differ from those produced following natural infection and could potentially interfere with the interpretation of diagnostic tests. We assessed anti-dengue IgG and IgM antibodies, and nonstructural protein 1 antigen profiles in the serum of adults who received a single dose of the tetravalent dengue vaccine TAK-003 as either an initially developed high-dose formulation or the standard approved formulation in a phase 2 study in Singapore (#NCT02425098). Immunoglobulin G and IgM profiles during the first 30 days postvaccination varied by baseline serostatus (microneutralization assay). Nonstructural protein 1 antigen was not detected in the serum of any participants. Vaccine-induced IgG and IgM antibodies can affect serological confirmation of subsequent dengue infection in vaccinees. These results highlight the limitations of using serological tests for dengue diagnosis, particularly in a postvaccination setting, and emphasize the need for more sensitive antigen- and molecular-based testing for accurate dengue diagnosis.
Automating the Generation of Notifiable Bacterial Disease Reports: Proof-of-Concept Study and Implementation in Six Hospitals in Thailand
Authors: Lim Cherry , Klaytong Preeyarach , Hantrakun Viriya , Rangsiwutisak Chalida , Phiancharoen Chadaporn , Tangwangvivat Ratanaporn , Kripattanapong Somkid , Jitpeera Charuttaporn , Poldech Wiratya , Jiramahasan Punya , Laosatiankit Bangon , Photivet Orawan , Sukbut Punchawee , Thongsri Warintorn , Kosasaeng Kailas , Chiwehanyon Bongkoch , Leesahud Nutjamee , Ritthong Preecha , Linreung Wandee , Aramrueang Panatda , Bhunyakitikorn Wichan , Iamsirithaworn Sopon , Limmathurotsakul Direk 
Published: May 2024

ABSTRACT.
Information on notifiable bacterial diseases (NBD) in low- and middle-income countries (LMICs) is frequently incomplete. We developed the AutoMated tool for the Antimicrobial resistance Surveillance System plus (AMASSplus), which can support hospitals to analyze their microbiology and hospital data files automatically (in CSV or Excel format) and promptly generate antimicrobial resistance surveillance and NBD reports (in PDF and CSV formats). The NBD reports included the total number of cases and deaths after Brucella spp., Burkholderia pseudomallei, Corynebacterium diphtheriae, Neisseria gonorrhoeae, Neisseria meningitidis, nontyphoidal Salmonella spp., Salmonella enterica serovar Paratyphi, Salmonella enterica serovar Typhi, Shigella spp., Streptococcus suis, and Vibrio spp. infections. We tested the tool in six hospitals in Thailand in 2022. The total number of deaths identified by the AMASSplus was higher than those reported to the national notifiable disease surveillance system (NNDSS); particularly for B. pseudomallei infection (134 versus 2 deaths). This tool could support the NNDSS in LMICs.
Clinical Characteristics and Outcomes of Disseminated Strongyloidiasis in the United States—A Multicenter Network Analysis
Authors: Henao-Martínez Andrés F. , Olivo Freites Christian , Agudelo Higuita Nelson I. , Marcos Luis A. , Chastain Daniel B. , Mohareb Amir M. , Tuells Jose , Villalpando-Carrion Salvador , Franco-Paredes Carlos 
Published: May 2024

ABSTRACT.
Human strongyloidiasis is a potentially life-threatening parasitic disease among immunocompromised hosts. We aim to determine the factors and mortality associated with disseminated strongyloidiasis. We conducted a U.S.-based multicenter retrospective cohort study to determine 90-day clinical outcomes for people diagnosed with Strongyloides infection in the TriNetX patient database. We identified adult patients with the International Classification of Diseases (10th revision, clinical modification) code for Strongyloides infection (B78) or a positive Strongyloides IgG antibody test and captured outcomes at 90 days. We identified 5,434 patients with strongyloidiasis, of whom 48 had disseminated strongyloidiasis for 0.9% prevalence of disseminated disease. Systemic connective tissue disorders, pulmonary eosinophilia, liver cirrhosis, blood disorders (monoclonal gammopathy, aplastic anemia, and lymphoid malignancy), malnutrition, alcohol use disorder, and transplantation status were frequent in patients with disseminated disease. Mortality was significantly higher in people with disseminated disease at 30 days (21%). The 90-day risk of hospitalization, bacteremia, and acute respiratory distress syndrome (ARDS) was higher in those with disseminated infection. People with disseminated strongyloidiasis had a heightened risk of hospitalization, bacteremia, acute respiratory distress syndrome, and mortality. The population at risk for severe strongyloidiasis infection is evolving, reflecting conditions in which glucocorticoids or additional immunosuppressive medications are commonly used for treatment.
Melioidosis and Activation from Latency: The “Time Bomb” Has Not Occurred
Authors: Howes Matthew , Currie Bart J. 
Published: May 2024

ABSTRACT.
Burkholderia pseudomallei, the causative agent of melioidosis has long been considered able to exist in a latent form. Seropositivity among U.S. soldiers returning from the Vietnam conflict led to melioidosis being dubbed “the Vietnamese time bomb.” Cases assigned to “(re)activation from latency” over 30 years of the Darwin Prospective Melioidosis Study (DPMS) were reviewed and reassessed and additional cases from DPMS years 31–34 were added. Historical reports of melioidosis attributed to activation from latency were reviewed. Some earlier DPMS cases and most historical cases described as activation from latency more accurately reflect undiagnosed chronic melioidosis, often with relapsing–remitting courses, rather than truly latent, asymptomatic infection. Such protracted disease should now be diagnosable much earlier, provided melioidosis is considered and laboratory facilities are available. The longest plausible duration of asymptomatic latency remains 29 years. In conclusion, activation from latency is a rare event in melioidosis, accounting in our analysis for under 3% of DPMS cases, consistent with why the Vietnamese time bomb never eventuated.
Percepciones de los estudiantes de educación física sobre el aprendizaje basado en problemas (ABP) (Physical education students' perceptions of problem-based learning (ABP))
Authors: Laclote-Gutierrez Guillermo , Azócar-Gallardo Jairo , Lara-Subiabre Brenda , Pereira-Berrios MR , Avila-Saldaña Claudio , Vera-Assaoka Tiago 
Published: May 2024

La sociedad actual requiere de sistemas educativos capaces de desarrollar nuevas habilidades y competencias que permitan a los futuros profesionales ser reflexivos y con habilidades de investigación, para resolver problemas del medio socio laboral. El objetivo de esta investigación es identificar los niveles de desarrollo de las habilidades personales y participativas en el ABP, según valoración de los estudiantes de la formación universitaria en educación física. Mediante un estudio cuantitativo descriptivo no experimental, se administró un cuestionario a estudiantes de educación física. Los resultados muestran niveles sensibles de desarrollo en relación a la formación mediante el ABP, seguido por el nivel de satisfacción respecto del proceso tutorial del ABP y las competencias personales y participativas.
Palabras claves: Metodologías Activas, Aprendizaje basado en problemas, Educación Superior, Satisfacción
Abstract. Today's society requires educational systems capable of developing new skills and competencies; that allow future professionals to be reflective and with research skills, to solve problems in the socio-labor environment. The objective of this research is to identify the levels of development of personal and participatory skills in the PBL, according to the assessment of the students of the university training in physical education. Through a non-experimental descriptive quantitative study, a questionnaire was administered to physical education students. The results show sensitive levels of development in relation to training through PBL, followed by the level of satisfaction regarding the PBL tutorial process and personal and participatory skills.
Key words: Active Methodologies, Problem-Based Learning, Higher Education, Satisfaction.
Anxiety in elite athletes, sex and age characteristics and association with sports
Authors: Pushcarov G. S. , Senatorova O. V. , Tempel L. A. , Butov D. I. , Turovinina E. F. 
Published: May 2024

Introduction: Long-term anxiety can lead to increased injuries and negatively affect physical performance, but it is also a significant risk factor for the development and progression of cardiovascular diseases. At the same time, participation in certain sports at a professional level is associated with an increased prevalence of risk factors such as excess body weight, dyslipidemia and hypertension. Therefore, the study of anxiety in elite athletes seems to us an urgent task.Objective: to assess the prevalence of anxiety of varying severity among elite athletes permanently residing in the Tyumen region, and to identify possible associations of anxiety indicators with sports, gender and age.Materials and methods: The study involved 141 elite athletes of the Tyumen region (40 (28.4 %) and 101 (71.6 %) female and male, respectively) aged from 14 to 38 years (average age 21.0 ± 4.2). Participants competed in both individual (biathlon and judo, n = 62 (44.0 %)) and team sports (volleyball, hockey, n = 79 (56.0%)). Anxiety (reactive and personal) was assessed using the Spielberger — Hanin questionnaire. To assess the independent relationship of the variables under consideration with anxiety indicators, multivariate analysis was used — multinomial logistic regression.Results: Severe reactive anxiety was found in 21 (15.7 %) athletes, and severe personal anxiety in 26 (19.5 %) athletes. 80 (59.7 %) athletes had moderate reactive anxiety, and 83 (62.4 %) had moderate personal anxiety. When conducting multivariate analysis, independent associations of reactive anxiety with age (OR = 1.25, 95 % CI 1.08–1.45, p = 0.003), types of sports (OR = 0.39, 95 % CI 0.17) were established -0.94, p=0.036) and gender (OR=0.23, 95 % CI 0.06–0.93, p=0.039). Personal anxiety was independently associated with gender (OR = 0.12, 95 % CI 0.02–0.63, p = 0.013) and type of sport (OR = 0.29, 95 % CI 0.11–0.77, p = 0.013).Conclusion: The prevalence of anxiety symptoms among elite athletes was quite high. Moreover, the indicator of reactive anxiety among them was independently and significantly associated with age, types of sports and gender, and the indicator of personal anxiety was associated with gender and types of sports.
EFEKTIVITAS PENGGUNAAN MEDIA TANAM AGRONIKA PADA PERTUMBUHAN DAN PRODUKSI JAGUNG MANIS (Zea mays saccharata sturt)
Authors: Rio Dewantara , Sanjaya Refki 
Published: May 2024

Abstract : Sweet corn production at the Indonesian farmer level is still very low. The low production is due to the many obstacles faced in the cultivation of sweet corn, including low soil fertility. The tendency of farmers to currently use inorganic fertilizers. The negative effect of using inorganic fertilizers is that the physical condition of the soil becomes worse, crop yields decrease from previous results. An alternative to overcome this negative effect is by using organic fertilizers. This fertilizer tends to increase the amount of water that can be held in the soil. in the soil and available to plants, as well as a source of energy for micro-organisms. The aim is to determine the effectiveness of the use of agronomic fertilizers on the growth of sweet corn, and to determine the level of effectiveness of the use of agronic fertilizers.
This study consisted of using agronic fertilizers with different dosage levels. The observed plant growth parameters were plant height, number of leaves, and stem diameter, while the observed production parameters were stover weight, firm weight and non-husked weight. Data analysis. Parameter data obtained were analyzed statistically with 95% variance then continued with Duncan's test at 5% level.
The results of the application of agronomic fertilizer types and dose levels of 2.4 Kg per plot, 4.8 Kg per plot, 7.2 Kg per plot, on sweet corn plants showed the highest growth and production with a better dose level of 7.2 per plot.

Keywords: Dosage, Sweet Corn, Growth, Organic Fertilizer, Productio