bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: The Structural Chemistry of Organosilicon Compounds
Authors: Kaftory Menahem , Kapon Moshe , Botoshansky Mark 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development and Application of the Analytical Methods with Spectrometry for Bio‐Related Compounds
Authors: Santa Tomofumi 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Route to 2‐Cyanobenzothiazoles via N‐Arylimino‐1,2,3‐dithiazoles.
Authors: Besson Thierry , Dozias Marie‐Joelle , Guillard Jerome , Rees Charles W. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Up‐regulation of interleukin‐17 expression by human papillomavirus type 16 E6 in nonsmall cell lung cancer
Authors: Chang Yih‐Hsin , Yu Chen‐Wei , Lai Li‐Chuan , Tsao Chang‐Hui , Ho Kuo‐Ting , Yang Shun‐Chun , Lee Huei , Cheng Ya‐Wen , Wu Tzu‐Chin , Shiau Ming‐Yuh 
Published: June 2010

AbstractBACKGROUND:Human papillomavirus (HPV) 16/18 infection is associated with nonsmoking lung cancer. In this study, the authors investigated a putative correlation between interleukin (IL)‐17 expression and HPV infection in clinical nonsmall cell lung cancer (NSCLC) tissues and examined the effects of HPV infection on a human NSCLC cell line.METHODS:IL‐17 expression was investigated in 79 NSCLC tumor tissues by immunohistochemistry. Growth rate, IL‐17 mRNA, and secreting protein levels were also examined in HPV 16/18 E6‐transfected H1299 human NSCLC cells.RESULTS:Immunohistochemical data showed that 48.1% of lung tumors had IL‐17 staining, which was significantly associated with patients' sex (P = .03), HPV infection (P = .002), and tumor stage (P = .03). Significant correlations of IL‐17 with IL‐6 (P < .001) and IL‐17 with Mcl‐1 (P < .001) expression were also observed. Cell growth rate was increased, and IL‐17/Mcl‐1 expression levels were elevated in HPV 16 E6‐transfected H1299 cells. The transfected E6 oncoproteins can significantly up‐regulate expression levels of IL‐17 and antiapoptotic protein Mcl‐1.CONCLUSIONS:The study suggests that HPV infection‐induced IL‐17 levels can stimulate Mcl‐1 expression through the PI3K pathway and promote lung tumor cell progression through a p53‐ and IL‐6‐independent pathway. Cancer 2010. © 2010 American Cancer Society.
Cellular and subcellular localization of the neuron‐specific plasma membrane calcium ATPase PMCA1a in the rat brain
Authors: Kenyon Katharine A. , Bushong Eric A. , Mauer Amy S. , Strehler Emanuel E. , Weinberg Richard J. , Burette Alain C. 
Published: June 2010

AbstractRegulation of intracellular calcium is crucial both for proper neuronal function and survival. By coupling ATP hydrolysis with Ca2+ extrusion from the cell, the plasma membrane calcium‐dependent ATPases (PMCAs) play an essential role in controlling intracellular calcium levels in neurons. In contrast to PMCA2 and PMCA3, which are expressed in significant levels only in the brain and a few other tissues, PMCA1 is ubiquitously distributed, and is thus widely believed to play a “housekeeping” function in mammalian cells. Whereas the PMCA1b splice variant is predominant in most tissues, an alternative variant, PMCA1a, is the major form of PMCA1 in the adult brain. Here, we use immunohistochemistry to analyze the cellular and subcellular distribution of PMCA1a in the brain. We show that PMCA1a is not ubiquitously expressed, but rather is confined to neurons, where it concentrates in the plasma membrane of somata, dendrites, and spines. Thus, rather than serving a general housekeeping function, our data suggest that PMCA1a is a calcium pump specialized for neurons, where it may contribute to the modulation of somatic and dendritic Ca2+ transients. J. Comp. Neurol. 518:3169–3183, 2010. © 2010 Wiley‐Liss, Inc.
Study of Carbon Monoxide Oxidation on Mesoporous Platinum
Authors: Esterle Thomas F. , Russell Andrea E. , Bartlett Philip N. 
Published: June 2010

AbstractH1 mesoporous platinum surfaces formed by electrodeposition from lyotropic liquid crystalline templates have high electroactive surface areas (up to 60 m2 g−1) provided by the concave surface within their narrow (≈2 nm diameter) pores. In this respect, they are fundamentally different from the flat surfaces of ordinary Pt electrodes or the convex surfaces of high‐surface‐area Pt nanoparticles. Cyclic voltammetry of H1 mesoporous Pt films in acid solution is identical to that for polycrystalline Pt, suggesting that the surfaces of the pores are made up of low‐index Pt faces. In contrast, CO stripping voltammetry on H1 mesoporous Pt is significantly different from the corresponding voltammetry on polycrystalline Pt and shows a clear prewave for CO oxidation and the oxidation CO at lower overpotential. These differences in CO stripping are related to the presence of trough sites where the low‐index Pt faces that make up the concave surface of the pore walls meet.
Tips for success: Fostering a good mentoring relationship
Authors: Kiefer Julie C. 
Published: June 2010

AbstractA mentor can mean the difference between a mentoree's failure and success. Yet mentoring is more than an altruistic venture. A good mentor will be more likely to recruit and retain strong student and postdoctoral candidates, and cultivate productive personnel. Despite these advantages, faculty often receive little, if any, mentoring training. Here, three panelists, Marianne Bronner‐Fraser, Ph.D., Kathy Iovine, Ph.D., and Carl Thummel, Ph.D., share their mentoring tips. Their mentorees also articulate how these accomplished mentors helped them to grow professionally and personally. Together, their insights outline ways to achieve a productive mentoring relationship, a topic of interest to mentors and mentorees alike. Developmental Dynamics 239:2136–2139, 2010. © 2010 Wiley‐Liss, Inc.
Endothelial SUR‐8 acts in an ERK‐independent pathway during atrioventricular cushion development
Authors: Yi Jing , Chen Muyun , Wu Xiaohui , Yang Xiao , Xu Tian , Zhuang Yuan , Han Min , Xu Rener 
Published: June 2010

AbstractSUR‐8, a conserved leucine‐rich repeats protein, was first identified as a positive regulator of Ras pathway in Caenorhabditis elegans. Biochemical studies indicated that SUR‐8 interacts with Ras and Raf, leading to the elevated ERK activity. However, the physiological role of SUR‐8 during mammalian development remains unclear. Here we found that germline deletion of SUR‐8 in mice resulted in early embryonic lethality. Inactivated SUR‐8 specifically in mouse endothelial cells (ECs) revealed that SUR‐8 is essential for embryonic heart development. SUR‐8 deficiency in ECs resulted in late embryonic lethality, and the mutant mice displayed multiple cardiac defects. The reduced endothelial‐mesenchymal transformation (EMT) and the reduced mesenchyme proliferation phase were observed in the atrioventricular canal (AVC) within the mutant hearts, leading to the formation of hypoplastic endocardial cushions. However, ERK activation did not appear to be affected in mutant ECs, suggesting that SUR‐8 may act in an ERK‐independent pathway to regulate AVC development. Developmental Dynamics 239:2005–2013, 2010 © 2010 Wiley‐Liss, Inc.
A method for stabilizing RNA for transfection that allows control of expression duration
Authors: Hayashi Toshinori , Lamba Deepak A. , Slowik Amber , Reh Thomas A. , Bermingham‐McDonogh Olivia 
Published: June 2010

AbstractRNA transfection methods have not proven to be as popular as DNA methods due to the highly transient nature of the RNA inside the cell. However, there are many advantages in using RNA for gene over‐expression, such as the rapidity of expression, the ability to express in all cell types without the need for cell‐type‐specific promoters, and the ability to analyze the effects of gene over‐expression in a transient manner. Therefore, we have developed a method (StabiLizingUtr: SLU) to stabilize the RNA for varying durations, using specific sequences from the 3′UTR of the Venezuelan equine encephalitis virus (VEEV). We have designed a plasmid for cloning genes upstream from repeated stabilizing sequences to generate mRNA with one or more VEEV‐stabilizing sequence motifs. We demonstrate this method in several cell and tissue types, including the mammalian cochlea, a tissue that has been difficult to transfect with other methods. Developmental Dynamics 239:2034–2010, 2010. © 2010 Wiley‐Liss, Inc.
Micellar electrokinetic chromatography for the determination of cortisol in urine samples in view of biomedical studies
Authors: Olędzka Ilona , Plenis Alina , Konieczna Lucyna , Kowalski Piotr , Bączek Tomasz 
Published: June 2010

AbstractAn MEKC method used for the determination of cortisol in urine was developed and elaborated. In turn, the measurements of urinary free cortisol provided the diagnostic information for excess adrenal production of cortisol. MEKC realized by the addition of anionic surfactant SDS to the buffer solution was demonstrated to be the appropriate mode for the separation of cortisol and dexamethasone was used as internal standard. A buffer solution composed of 10 mM sodium tetraborate and 50 mM SDS at pH 8.8 was used. The MEKC assay was evaluated by analyzing a series of urine samples containing cortisol in variable concentrations. The proposed method was validated for specificity, linearity, LODs and LOQs, precision and trueness. The LOQ for cortisol equaled 5 ng/mL. The method was selective and reliable for identification and can detect changes of endogenous levels of cortisol in urine under different stress situations.
Landscape‐scale controls on the spatial distribution of caesium 137: A study based on an airborne geophysical survey across Northern Ireland
Authors: Rawlins B. G. , Scheib C. , Beamish D. , Webster R. , Tyler A. N. , Young M. E. 
Published: June 2010

AbstractThe spatial distribution of 137Cs across the landscape and the processes controlling its redistribution are of interest because (i) 137Cs has been widely used to quantify the movement of soil and sediments and (ii) substantial fallout of 137Cs after the Chernobyl accident has led to contamination of foodstuffs in some places. A high‐resolution airborne geophysical radiometric survey of Northern Ireland has provided an opportunity to study the distribution and possible redistribution of 137Cs.The 137Cs activity (recorded at 1·2 million points) is distributed in a series of bands oriented approximately 160° and 115° clockwise from north. Geostatistical analysis of the data shows a strong, short‐range structure (correlation ranges between 0·6 and 8 km) in 137Cs activity across the vast majority of the region; the spatial distribution shows association with a published, coarse‐scale depositional pattern of 137Cs from Chernobyl. Two indices of land form derived from a digital elevation model, namely compound topographic index and the length–slope factor of the Revised Universal Soil Loss Equation, account for only 3% of the variance in 137Cs activity. In contrast, soil type and land cover in combination (including their interaction) account for 20% of the variance. In areas that received moderate fallout from Chernobyl, soil type alone accounts for a substantial proportion of the spatially correlated 137Cs activity. We attribute this to each soil type having a fairly uniform radiocaesium interception potential that differs from those of other soil types and that this potential controls the vertical migration of 137Cs. Over the granitic Mourne Mountains there is a strong spatial cross‐correlation between 137Cs activity and airborne estimates of soil potassium, suggesting that the latter provides a measure of the soil's radiocaesium interception potential; this is probably dominated by the quantity of the mineral illite. Copyright © 2010 John Wiley & Sons, Ltd. and British Geological Survey
The vomeronasal organ is not involved in the perception of endogenous odors
Authors: Frasnelli Johannes , Lundström Johan N. , Boyle Julie A. , Katsarkas Athanasios , Jones‐Gotman Marilyn 
Published: June 2010

AbstractChemosensory‐based communication is a vital signaling tool in most species, and evidence has recently emerged in support of the notion that humans also use social chemosignals (so‐called pheromones) to communicate. An ongoing controversy does exist, however, concerning the receptor organ through which these chemicals are processed. There is a widespread belief that the vomeronasal organ (VNO) is responsible for processing social chemosignals in humans. Here we demonstrate that functional occlusion of the VNO does not change the percept of, sensitivity toward, or functional neuronal processing of a putative human pheromone. Perithreshold and suprathreshold perception of the endogenous chemical androstadienone (AND) were compared, as were positron emission tomography brain activations evoked by AND when the VNO was either occluded or left open. In addition, we compared sensitivity to AND in subjects with an identifiable VNO to those in whom no VNO could be detected. Thus we could examine the effects of the VNO at several different levels of processing. Occlusion or absence of the VNO did not affect either the perceptual measurements or the functional processing of the putative human pheromone, AND. These results provide strong evidence that the human VNO has no obvious function. Pheromonal communication in humans may be conveyed via the main olfactory system. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Is the human left middle longitudinal fascicle essential for language? A brain electrostimulation study
Authors: De Witt Hamer Philip C. , Moritz‐Gasser Sylvie , Gatignol Peggy , Duffau Hugues 
Published: June 2010

AbstractHuman brain pathways required for language processing are poorly known. A new white matter tract in humans, the middle longitudinal fascicle, has recently been anatomically determined by diffusion tensor imaging and suggested to be essential for language. Our aim is to determine the importance of the middle longitudinal fascicle for language processing. This study is based on 8 patients with glioma resection at least involving the superior temporal gyrus of the left dominant hemisphere. Language is systematically examined pre‐ and postoperatively at 3 months. Intraoperative electrostimulation is used to map cortical and subcortical structures as functional boundaries of the glioma resection, including those essential for language processing. The resections are extensive (on average 62 ml, ranging from 21 to 111 ml) and include a large part of the middle longitudinal fascicle in all patients. Intraoperatively, no interference with picture naming is observed by electrostimulation of the middle longitudinal fascicle, while in all patients the inferior fronto‐occipital fascicle is identified by eliciting semantic paraphasia as functional boundary. Postoperatively, no new permanent language deficits are detected by systematic language examination. Therefore, we suggest that the middle longitudinal fascicle may participate but is not essential for language processing. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Application of whole‐brain CBV‐weighted fMRI to a cognitive stimulation paradigm: Robust activation detection in a stroop task experiment using 3D GRASE VASO
Authors: Poser Benedikt A. , Norris David G. 
Published: June 2010

AbstractBrain activation studies generally utilize blood oxygenation level dependent (BOLD) contrast, most commonly measured using the gradient‐echo echo‐planar imaging (EPI) technique. BOLD contrast arises from regional changes in cerebral blood flow (CBF), cerebral blood volume (CBV), and the local metabolic rate of oxygen consumption. An alternative to BOLD is the detection of activation through direct measurement of these parameters. A noninvasive approach to measure activation‐related CBV changes is the vascular space occupancy (VASO) method, which exploits blood as an endogenous contrast agent by selectively nulling the magnetization of the water spins in the blood. Using a recently developed multislice variant of VASO that enables single‐shot whole‐brain coverage by virtue of a three‐dimensional GRASE readout, we here present the first application of VASO to an fMRI study with a whole‐brain cognitive task. Within acceptable measurement times (∼12 minutes), brain activation during a Stroop color‐word matching task could be detected reliably both on the group (N = 12) and single subject level, as evident from a qualitative comparison with separately acquired BOLD data and literature reports. Hum Brain Mapp, 2011. © 2010 Wiley‐Liss, Inc.
Alternative technical efficiency measures: Skew, bias and scale
Authors: Feng Qu , Horrace William C. 
Published: June 2010

SUMMARYIn the fixed‐effects stochastic frontier model an efficiency measure relative to the best firm in the sample is universally employed. This paper considers a new measure relative to the worst firm in the sample. We find that estimates of this measure have smaller bias than those of the traditional measure when the sample consists of many firms near the efficient frontier. Moreover, a two‐sided measure relative to both the best and the worst firms is proposed. Simulations suggest that the new measures may be preferred depending on the skewness of the inefficiency distribution and the scale of efficiency differences. Copyright © 2010 John Wiley & Sons, Ltd.
Firm size distributions through the lens of functional principal components analysis
Authors: Huynh Kim P. , Jacho‐Chávez David T. 
Published: June 2010

AbstractWe explore the dynamics of firm size distributions through the lens of Functional Principal Component Analysis as proposed by Kneip and Utikal (2001). Using samples of UK firms from Geroski et al. (2003) we apply the methodology to their balanced panel sample, present in the sample for all 31 years. We extend the analysis to an unbalanced panel sample (minimum and maximum spell of five and 31 years). For the unbalanced panel, we reject the null hypothesis that the densities are the same, while we fail to reject the null hypothesis for the balanced panel. These results suggest that inclusion of young firms that non‐randomly exit will affect the firm size distribution. The difference in the results is due to the presence of survivorship bias. These results highlight the attractiveness of this methodology and its ability to succinctly describe the time dynamics of distributions without the need for explicit parametric specification of the growth and exit processes. Copyright © 2010 John Wiley & Sons, Ltd.
A novel gelatin sponge for accelerated hemostasis
Authors: Hajosch Reiner , Suckfuell Markus , Oesser Steffen , Ahlers Michael , Flechsenhar Klaus , Schlosshauer Burkhard 
Published: June 2010

AbstractTo more effectively manage the substantial bleeding encountered during surgical procedures in oto‐rhino‐laryngology, we developed a novel hemostatic sponge made of pharmaceutical grade, chemically cross‐linked gelatin. The sponge is characterized by a high pore density, reduced ligaments, and a high nanoscale roughness of lamella surfaces in the matrix. In vitro blood uptake assays revealed a very rapid absorption of human blood, which was two to three times faster than that measured with comparative hemostyptic devices. In an in vitro hemorrhage model using human veins, the novel gelatin sponge matrix induced hemostasis less than a minute after bleeding was induced. The sponge was shown to bring about rapid hemostasis when it was administered in a young patient suffering from acute bleeding of a pharyngeal angiofibroma, even though the patient had been treated with an anticoagulant because of a transient ischemic attack. As the gelatin matrix of the sponge is biocompatible and resorbable, the hemostyptic device could be left in place and was shown to be resorbed within 2 weeks. We hypothesize that the excellent hemostatic performance of the sponge might be linked to enhanced capillary effects in conjunction with optimized anchoring of fibrinogen on the nano‐rough material surface, as suggested by scanning electron microscopy. The novel gelatin sponge appears to be a promising hemostatic matrix, which could be of great benefit for patients suffering from epistaxis and other acute injuries resulting in severe bleeding. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.
Small peptide (P‐15) bone substitute efficacy in a rabbit cancellous bone model
Authors: Lindley Emily M. , Guerra Fernando A. , T. Krauser Jack , Matos Sergio M. , Burger Evalina L. , Patel Vikas V. 
Published: June 2010

AbstractP‐15 is a synthetic 15‐amino acid residue identical to the cell binding domain of type I collagen. P‐15 can be adsorbed onto anorganic bovine bone mineral (ABM) and will enhance cell attachment and subsequent cell activation. Although ABM/P‐15 has been studied as a bone graft substitute in the oral cavity, its use in orthopedic models has been limited. Thus, this study investigated the efficacy of ABM/P‐15 treatment in a rabbit model of long bone cancellous healing. Defects were created in the distal femurs and proximal medial tibiae of rabbits and were filled with either ABMP/P‐15 suspended in hydrogel, ABM alone suspended in hydrogel, hydrogel carrier alone, or no graft material. Rabbits were sacrificed at 1, 2, 4, or 8 weeks postsurgery, and the femurs and tibiae were harvested. Histomorphometric analyses indicated that defects treated with ABM/P‐15 had significantly larger areas of new bone formation than the other three treatments at 2 and 8 weeks postsurgery. ABM/P‐15 treated defects also had significantly more bone growth than defects left empty or filled with ABM alone at 4 weeks postsurgery. Furthermore, histological examination did not reveal acute inflammatory infiltrate cells in any of the treatment conditions. These results are consistent with the findings of ABM/P‐15 use in human oral‐maxillofacial studies and in large animal spine fusion models. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.