bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time management practice and associated factors among health professionals working in public and private hospitals in Dessie City, Northeast Ethiopia: a comparative cross-sectional study
Authors: Yimer Ali , Feleke Amsalu , Yazachew Lake , Ahmed Mohammed , Seid Seada , Adem Mohammed , Mustofa Semira Muhidin , Markos Merkineh , Sirage Nurye , Kassaw Abdulaziz Kebede , Mustefa Nuru Muhammed , Ali Dawed , Dellie Endalkachew 
Published: May 2024

BackgroundTime management is a widely ignored concern in all types of organizations, including the healthcare system, despite its crucial role in the achievement of personal and organizational goals. Therefore, determining the practice of time management and its associated factors among health professionals is of paramount importance.ObjectiveWe aimed to assess time management practice and associated factors among health professionals working in public and private hospitals in Dessie City, Northeast Ethiopia.MethodsA comparative cross-sectional study was conducted from 24 March to 24 April 24 2021 among 660 health professionals (220 from private hospitals and 440 from public hospitals), who were randomly selected using a stratified sampling technique. A self-administered questionnaire was used to collect data. A multivariable binary logistic regression model was run separately for public and private hospitals. A p-value of &lt; 0.05 and a 95% confidence interval were reported to be statistically significant.ResultsA total of 615 participants responded to the survey, which resulted in a response rate of 93.2%. The magnitude of good time management practice among health professionals in both public and private hospitals was reported to be 57.1% (95% CI: 53.5–60.8%). However, the magnitude differed between public [50.1% (95% CI:45.5–54.7%)] and private hospitals [70.9% (95% CI: 63.5–76.7%)]. Living with families (AOR: 5.39, 95% CI: 1.84–15.77), satisfaction with compensation and benefits (AOR: 7.83, 95% CI: 1.97–31.16), satisfaction with work autonomy (AOR: 7.10, 95% CI: 1.94–25.95), and having a good plan (AOR: 3.42, 95% CI: 1.15–10.13) were statistically significant predictors of time management practice in private hospitals. Satisfaction with an organizational policy and strategy (AOR: 2.34, 95% CI: 1.25–4.36), performance appraisal (AOR: 1.95, 95% CI: 1.13–3.36), work autonomy (AOR: 1.92, 95% CI: 1.12–3.27), and the good approach of employees toward time (AOR: 2.12, 95% CI: 1.26–3.58) were statistically significant predictors of time management practice in public hospitals.ConclusionThe magnitude of a good time management practice in public and private hospitals in the study area was low. The practice was observed to be higher in private hospitals than in public hospitals. The study revealed that the magnitude and associated factors of time management practice vary between hospitals, indicating the need for targeted intervention.
Coverage and determinants of second-dose measles vaccination among under-five children in East Africa countries: a systematic review and meta-analysis
Authors: Alemu Tewodros Getaneh , Tamir Tadesse Tarik , Workneh Belayneh Shetie , Mekonen Enyew Getaneh , Ali Mohammed Seid , Zegeye Alebachew Ferede , Wassie Mulugeta , Kassie Alemneh Tadesse , Tekeba Berhan , Gonete Almaz Tefera 
Published: May 2024

BackgroundOne of the biggest breakthroughs of contemporary medicine is measles vaccination. It is essential for the total elimination of measles. Understanding the magnitude and determinants of effective second-dose measles vaccination coverage is a critical task. Accordingly, we set out to check the best available evidence of the pooled second-dose measles vaccination coverage among under-five children in East Africa.MethodWe searched electronic databases such as PubMed, Google Scholar, Cochrane, and others. Two reviewers separately carried out the search of the Joanna Briggs Institute, selection of studies, critical appraisal, and data extraction. A third party was involved in resolving the disagreement among the reviewers. Seven studies included in this study, four from Ethiopia, two from Kenya, and one from Tanzania were cross-sectional and published in English language, with publication dates before 29 November 2023. Articles lacking full-text, the intended outcome, and that are not qualitative studies were excluded from the analysis. The Microsoft Excel checklist was used to extract the data and then exported to STATA 11. In addition, I2, Funnel plots, and Egger's test were employed to measure heterogeneity and detect publication bias, respectively. A random effect model was used.ResultThe meta-analysis includes a total sample size of 4,962 children from seven articles. The pooled prevalence of second-dose measles vaccination among under-five children in East Africa was found to be 32.22% [95% CI; (18.82, 45.63)], and the significant factors were as follows: birth order (1.72; OR = 95% CI: 1.32, 2.23), information about measles-containing second-dose vaccine (MCV 2) (7.39; OR = 95% CI: 5.21, 10.50), mother's marital status (1.47; OR = 95% CI: 1.05, 2.07), complete immunization for other vaccines (2.17; OR = 95% CI: 1.49, 3.17), and distance of vaccination site (3.31; OR = 95% CI: 2.42, 4.53).ConclusionThe current study found that pooled prevalence of second-dose measles vaccination coverage among under-five children was still very low. It was also observed that birth order, distance of the vaccination site, complete immunization for other vaccines, mother's marital status, and information about MCV were factors associated with second-dose measles vaccination. These factors imply that there is a need for countries and their partners to act urgently to secure political commitment, expand primary health service and health education, and increase vaccination coverage.
Quality assessment of mHealth apps: a scoping review
Authors: Giebel Godwin Denk , Speckemeier Christian , Schrader Nils Frederik , Abels Carina , Plescher Felix , Hillerich Vivienne , Wiedemann Desiree , Börchers Kirstin , Wasem Jürgen , Blase Nikola , Neusser Silke 
Published: May 2024

IntroductionThe number of mHealth apps has increased rapidly during recent years. Literature suggests a number of problems and barriers to the adoption of mHealth apps, including issues such as validity, usability, as well as data privacy and security. Continuous quality assessment and assurance systems might help to overcome these barriers. Aim of this scoping review was to collate literature on quality assessment tools and quality assurance systems for mHealth apps, compile the components of the tools, and derive overarching quality dimensions, which are potentially relevant for the continuous quality assessment of mHealth apps.MethodsLiterature searches were performed in Medline, EMBASE and PsycInfo. Articles in English or German language were included if they contained information on development, application, or validation of generic concepts of quality assessment or quality assurance of mHealth apps. Screening and extraction were carried out by two researchers independently. Identified quality criteria and aspects were extracted and clustered into quality dimensions.ResultsA total of 70 publications met inclusion criteria. Included publications contain information on five quality assurance systems and further 24 quality assessment tools for mHealth apps. Of these 29 systems/tools, 8 were developed for the assessment of mHealth apps for specific diseases, 16 for assessing mHealth apps for all fields of health and another five are not restricted to health apps. Identified quality criteria and aspects were extracted and grouped into a total of 14 quality dimensions, namely “information and transparency”, “validity and (added) value”, “(medical) safety”, “interoperability and compatibility”, “actuality”, “engagement”, “data privacy and data security”, “usability and design”, “technology”, “organizational aspects”, “social aspects”, “legal aspects”, “equity and equality”, and “cost(-effectiveness)”.DiscussionThis scoping review provides a broad overview of existing quality assessment and assurance systems. Many of the tools included cover only a few dimensions and aspects and therefore do not allow for a comprehensive quality assessment or quality assurance. Our findings can contribute to the development of continuous quality assessment and assurance systems for mHealth apps.Systematic Review Registrationhttps://www.researchprotocols.org/2022/7/e36974/, International Registered Report Identifier, IRRID (DERR1-10.2196/36974).
Investigating Earth surface deformation with SAR interferometry and geomodeling in the transborder Meuse–Rhine region
Authors: Schlögel Romy , Owczarz Karolina , Orban Anne , Havenith Hans-Balder 
Published: May 2024

Introduction: This study aims to differentiate local and regional ground uplift, as well as sub-regional subsidence induced by groundwater level drawdown, which are possibly enhanced across fault structures, as monitored by various synthetic aperture radar interferometry (InSAR) processing methods. A buoyant mantle plume under the Eifel may be responsible for the regional ground uplift, including the Weser–Geul (BE) and South Limburg regions (NL), which could negatively affect the area proposed for the future Einstein Telescope.Methods: Different InSAR processing techniques are compared to evaluate their limits in tracking fault structures on a time series of Copernicus Sentinel-1 images while detecting and measuring ground motion based on their phase signature. The results present an overall stable ground for the Euregio Meuse–Rhine region, especially at the Belgian–Dutch border, while tectonic activity is observed along the German side of the Rhine Graben.Results: As the current neotectonic activity in the target area was not well known, we performed a spatiotemporal analysis of ground deformation associated with the presence of NW–SE-trending normal faults where karst also develops, as well as along the Variscan NE–SW-trending thrust faults. This work demonstrates that the identification of deformation hazards using satellite remote sensing (and connected seismological) techniques is challenging mainly due to (very) small regional scale deformation, terrain conditions, and SAR properties.Discussion: Thus, the results mostly indicate ground stability over the area; however, also some agricultural activities were observed, as was deformation along some infrastructure such as railways. Displacements of millimetric order measured along the faults located near the Geul valley (BE) are probably related to old mining activities.
Longitudinal assessment of syringomyelia in Pomeranians
Authors: Santifort Koen M. , Carrera Ines , Mandigers Paul J. J. 
Published: May 2024

IntroductionChiari-like malformation (CM) and syringomyelia (SM) are disorders that, in dogs, affect mainly small and toy breeds, including the Pomeranian. These disorders are linked to a great number of (owner-reported) clinical signs (ORCS) suggestive of pain. Aging was associated with an increased risk of having SM in several studies. However, there are only a few longitudinal studies that assess the presence and severity of CM/SM over time in CKCS dogs and progression of SM was linked to progression of clinical signs. The aim of this study was to investigate ORCS, CM/SM classification, and quantitative syrinx parameters in relation to progression of time (age) within individual Pomeranians.Materials and methodsPomeranians with or without ORCS and with or without diagnoses of CM/SM were included that had undergone two (or more) MRI studies of the craniocervicothoracic region between January 2020 and June 2023. Classification of CM/SM and quantitative syrinx measurements were performed. Absolute values as well as ratios for syrinx height, width, and cross-sectional area were included for analysis.ResultsA total of 19 Pomeranians were included in the study, of which 11 were male (58%) and 8 were female (42%). The median age at the time of MRI1 was 26 months (range 7–44 months). The median scan interval was 26 months (range 11–49 months). Eleven dogs (58%) were presented with ORCS at the time of MRI1, whereas the other 8 dogs (42%) had no ORCS at that time. At the time of MRI2, there were 17/19 dogs (89%) with ORCS and 2/19 dogs without ORCS (11%). Dogs were significantly more likely to have ORCS at MRI2 than MRI1 (p = 0. 0411). There was no significant difference between CM/SM classification at the time of MRI1 and MRI2. Significant differences were found between MRI1 and MRI2 for syrinx height (based on transverse images) (absolute value and ratio P = 0.0059), syrinx width (absolute value P = 0.1055, ratio P = 0.0039), and syrinx cross sectional area (absolute value P = 0.0195, ratio P = 0.0217).DiscussionThere are differences in the presence or absence of ORCS as well as quantitative syrinx measurements in Pomeranians at different ages. This finding supports that longitudinal changes occur in the SM status of Pomeranians.
GhCLCc-1, a Chloride Channel Gene from Upland Cotton, Positively Regulates Salt Tolerance by Modulating the Accumulation of Chloride Ions
Authors: Li Wenhao , Gao Siqi , Zhao Yinghao , Wu Yuchen , Li Xiaona , Li Jianing , Zhu Wei , Ma Zongbin , Liu Wei 
Published: May 2024

The ionic toxicity induced by salinization has adverse effects on the growth and development of crops. However, researches on ionic toxicity and salt tolerance in plants have focused primarily on cations such as sodium ions (Na+), with very limited studies on chloride ions (Cl−). Here, we cloned the homologous genes of Arabidopsis thaliana AtCLCc, GhCLCc-1A/D, from upland cotton (Gossypium hirsutum), which were significantly induced by NaCl or KCl treatments. Subcellular localization showed that GhCLCc-1A/D were both localized to the tonoplast. Complementation of Arabidopsis atclcc mutant with GhCLCc-1 rescued its salt-sensitive phenotype. In addition, the silencing of the GhCLCc-1 gene led to an increased accumulation of Cl− in the roots, stems, and leaves of cotton seedlings under salt treatments, resulting in compromised salt tolerance. And ectopic expression of the GhCLCc-1 gene in Arabidopsis reduced the accumulation of Cl− in transgenic lines under salt treatments, thereby enhancing salt tolerance. These findings elucidate that GhCLCc-1 positively regulates salt tolerance by modulating Cl− accumulation and could be a potential target gene for improving salt tolerance in plants.
Vascular Access Outcomes in Patients with Autosomal Dominant Polycystic Kidney Disease
Authors: Laboyrie Suzanne L. , Svensson Maria K. , Josemans Sabine , Sigvant Birgitta , Rotmans Joris I. , Welander Gunilla 
Published: May 2024

Key Points

More patients with autosomal dominant polycystic kidney disease received their first intervention to re-establish vascular access patency.Patients with autosomal dominant polycystic kidney disease do not require differential monitoring and treatment of hemodialysis vascular access.

Background
Autosomal dominant polycystic kidney disease (ADPKD) is a leading hereditary cause of ESKD, often using hemodialysis as a form of RRT. Patients with ADPKD may also present with extrarenal manifestations, including arterial aneurysms. The gold standard for hemodialysis access is an arteriovenous vascular access (VA), such as arteriovenous fistulas (AVFs) or arteriovenous grafts (AVGs). However, limitations, such as low VA flow and inadequate AVF outward remodeling, affect VA utilization. This study aimed to explore whether ADPKD affects patency rates of AVFs/AVGs in comparison with other underlying ESKD causes.

Methods
We conducted a retrospective cohort study using data from the Swedish Renal Registry from 2011 to 2020, with follow-up until 2022. We included 496 patients with ADPKD and 4321 propensity score–matched controls. VA patency rates of patients with ADPKD were compared with those of non-ADPKD patients using Kaplan–Meier survival curves and Mantel–Cox log-rank test. Interventions to maintain or restore patency were also analyzed.

Results
Patients with ADPKD constituted 8.0% of all patients, with a higher proportion in the pre-ESKD phase during VA creation (51.6% versus 40.6%). No significant differences were observed in primary, postcannulation primary, secondary, or functional patency between patients with ADPKD and non-ADPKD patients. However, more VAs were ligated in patients with ADPKD (10.5% versus 7.7%, P = 0.03), and they underwent more first interventions to re-establish flow (49.4% versus 41.9%, P = 0.02).

Conclusions
These findings suggest that AVF/AVG patency remains comparable in patients with ESKD with or without ADPKD, and VA monitoring and treatment strategies for patients with ADPKD should align with those for individuals with other ESKD causes.
Genetic Analysis of Severe Polycystic Liver Disease in Japan
Authors: Mizuno Hiroki , Besse Whitney , Sekine Akinari , Long Kelly T. , Kurihara Shigekazu , Oba Yuki , Yamanouchi Masayuki , Hasegawa Eiko , Suwabe Tatsuya , Sawa Naoki , Ubara Yoshifumi , Somlo Stefan , Hoshino Junichi 
Published: May 2024

Key Points

Among patients with severe polycystic liver disease (PLD) (height-adjusted total liver volume of <1800 ml/m), PKD2 variants were found in 34%.Three patients with PKD1 or PKD2 variants are reported with severe PLD but normal-sized kidneys (hTKV of < 250 ml/m).

Background
Polycystic liver disease (PLD) is present in most patients with autosomal dominant polycystic kidney disease (ADPKD). PLD can alternatively be found with few, if any, kidney cysts as a diagnosis of isolated PLD (autosomal dominant PLD [ADPLD]). Several genes are identified as causative for this spectrum of phenotypes; however, the relative incidence of genetic etiologies among patients with severe PLD is unknown.

Methods
Patients with ADPKD or ADPLD having severe PLD defined as height-adjusted total liver volume (hTLV) >1800 ml/m were recruited. Subsequent clinical care was followed. Genetic analysis was performed using whole exome sequencing.

Results
We enrolled and sequenced 49 patients (38 women, 11 men). Pathogenic or suspected pathogenic variants in polycystic disease genes were found in 44 of 49 patients (90%). The disease gene was PKD1 in 20 of 44 patients (45%), PKD2 in 15 of 44 patients (34%), PRKCSH in 5 of 44 patients (11%), GANAB in 2 of 44 patients (5%), SEC63 in 1 of 44 patients (2%), and ALG8 in 1 of 44 patients (2%). The median hTLV was no different between genetically defined ADPKD and ADPLD groups (4431 [range, 1817–9148] versus 3437 [range, 1860–8211]) ml, P = 0.77), whereas height-adjusted kidney volume was larger as expected in ADPKD than in ADPLD (607 [range, 190–2842] versus 179 [range, 138–234] ml/m, P < 0.01). Of the clinically defined ADPKD patients, 20 of 38 patients (53%) were PKD1, 15 of 38 (39%) were PKD2, and 3 (8%) remained genetically unsolved. Among patients with a pathogenic PKD1 or PKD2 variant, we found three patients with a liver-dominant ADPKD (severe PLD with height-adjusted total kidney volume <250 ml/m).

Conclusions
ADPLD-related genes represent 20% of patients with severe PLD in our cohort. Of those enrolled with ADPKD, we observed a higher frequency of PKD2 carriers than in any previously reported ADPKD cohorts. Although there was no significant difference in the hTLV between patients with PKD1 and PKD2 in this cohort, our data suggest that enrollment on the basis of severe PLD may enrich for patients with PKD2.
ETYKA W DZIALALNOSCI ZAWODOWEJ: JEJ ZNACZENIE I ROLA
Authors: Bagrij Maria , Greczanik Natalia 
Published: May 2024

Professional morality consists primarily of such activities, the object of which is a person. Undoubtedly, working with people presents unique situations, difficulties, and contradictions that need to be resolved and overcome in the course of the activity itself. The qualitative peculiarity of the nature of relations between people in each profession implies that the activity complies with certain social norms and standards, moral and ethical requirements. Therefore, professional morality, on the one hand, is a component of general morality, and on the other hand, it has a qualitative specificity. The connection between them is expressed in the dialectic of the general and the particular. Ethics plays an important role in all areas of life, including professional activities. In a professional context, ethics defines the rules and norms of behavior that are aimed at ensuring fairness, trust and responsibility in the performance of professional duties.
The basic principles of professional ethics may include: honesty and integrity: professionals must demonstrate honesty and a high level of integrity, refraining from fraud, forgery and dishonesty. Confidentiality: the obligation to maintain the confidentiality of information obtained in the course of work that relates to clients, patients or other parties.
Integrity and equality: ensuring fairness in dealing with customers, patients, colleagues and other stakeholders and avoiding discrimination. Responsibility: taking responsibility for your actions and accepting the consequences of your actions. Social responsibility: taking into account the impact of one's activities on society and the environment, and adhering to social standards and principles.
The Influence of Product Price, Outlet Location, and Discounts on the Interest to Rebuy
Authors: Sinurat Andrio Avelino , Simanjorang Elida Florentina Sinaga , Zebua Yuniman 
Published: May 2024

Product prices, outlet locations, and discounts are several important factors in influencing consumer repurchase intentions. Reasonable and affordable prices can encourage consumers to buy products again. Strategic and easily accessible sales locations can also increase consumer interest in repurchasing a product. The discount at a lower price will broaden consumer interest to make repeat purchases. This study aims to describe and test how much influence partially and simultaneously the price, outlet location, and discount variables have on repurchasing interest for popcorn snacks in the city of Rantauprapat. This type of research is quantitative descriptive research with 100 respondents. The results of the research show that partially the price, outlet location, and environment variables have a positive and significant effect on the intention to repurchase popcorn snacks. The location of popcorn sales outlets that are easy to reach and easy to find is the most dominant reason for a consumer to make a repeat purchase, then the price is competitive according to taste and followed by a discount for purchasing a certain amount. Simultaneously it also shows that price, location, and discount have a positive and significant effect on the intention to repurchase popcorn in the city of Rantauprapat.