bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neue Arzneimittel für Kleintiere 2023
Authors: Emmerich Ilka Ute 
Published: May 2024

ZusammenfassungIm Jahr 2023 kamen für Kleintiere 2 neue Wirkstoffe auf den deutschen
Tierarzneimittelmarkt: das strukturelle, aber nicht funktionelle Analog des
hemmenden Botenstoffes Gamma-Aminobuttersäure Pregabalin mit anxiolytischer
Wirkkomponente und der Dopaminagonist Ropinirol als Augentropfen zum Auslösen
von Erbrechen. Zwei Wirkstoffe erhielten eine Tierartenerweiterung. Die
Phosphorverbindung Butafosfan wurde auch für Pferde, Hunde und Katzen und das
Mineral Natriumchlorid als isotonische Natriumchloridlösung auch für Kaninchen
und Meerschweinchen zugelassen. Des Weiteren kamen für Kleintiere auf den Markt:
ein Wirkstoff (Dexamethason) in einer neuen Darreichungsform, ein Wirkstoff
(Hydrocortisonaceponat) mit einer neuen Anwendungsart, ein Wirkstoff mit einem
neuen Wirkstoffgehalt (Firocoxib) und eine neue Wirkstoffkombination
(Gentamicin+Mometason+Posaconazol). Außerdem ist eine Wirkstoffkombination
(Diprophyllin+Heptaminol) wieder auf dem Markt für Kleintiere verfügbar.
Absorbable versus Nonabsorbable Sutures for Facial Skin Closure: A Systematic Review and Meta-analysis of Clinical and Aesthetic Outcomes
Authors: Malhotra Kashish , Bondje Sophie , Sklavounos Alexandros , Mortada Hatan , Khajuria Ankur 
Published: May 2024

AbstractWhen repairing facial wounds, it is crucial to possess a thorough understanding of suitable suture materials and their evidence base. The absence of high-quality and comprehensive systematic reviews poses challenges in making informed decisions. In this study, we conducted a review of the existing literature and assessed the quality of the current evidence pertaining to the clinical, aesthetic, and patient-reported outcomes associated with absorbable and nonabsorbable sutures for facial skin closure.The study was registered on Prospective Register of Systematic Reviews. We conducted searches on Embase, Ovid, and PubMed/MEDLINE databases. Only randomized controlled trials (RCTs) were eligible for inclusion in this study. Additionally, the risk of bias in the randomized studies was assessed using Cochrane's Risk of Bias Tool.The study included a total of nine RCTs involving 804 participants with facial injuries. Among these injuries, absorbable sutures were utilized in 50.2% (403 injuries), while nonabsorbable sutures were employed in 49.8% (401 injuries). The analysis of cosmesis scales revealed no statistically significant difference between absorbable and nonabsorbable sutures regarding infections (p = 0.72), visual analog scale (p = 0.69), wound dehiscence (p = 0.08), and scarring (p = 0.46). The quality of the included studies was determined to have a low risk of bias.Absorbable sutures can be considered a suitable alternative to nonabsorbable sutures, as they demonstrate comparable aesthetic and clinical outcomes. Future high-quality studies with a level I evidence design and cost-effectiveness analysis are necessary to enhance clinician–patient shared decision-making and optimize the selection of suture materials.Level of evidence is I, risk/prognostic study.
Early Predictors of Remission in Acromegaly Patients after Pure Endoscopic Endonasal Transsphenoidal Surgery
Authors: Cetinalp Nuri Eralp , Akkus Gamze , Seydaoglu Gulsah , Ozsoy Kerem Mazhar , Akbaba Mevlana , Baykara Okay , Oktay Kadir , Erman Tahsin 
Published: May 2024

Abstract
Objective Surgery is the first-line treatment in acromegaly but it takes months to confirm remission. It is crucial to determine remission early in order to inform the patient and plan further treatment options. We aimed to evaluate the predictors of remission at the early phase after endoscopic endonasal pituitary surgery in acromegaly patients.
Methods Fifty-four growth hormone (GH)-adenoma patients operated via pure endoscopic endonasal approach were analyzed in this observational study. We compared the basic clinical, radiological characteristics, and the preoperative and postoperative hormone levels in terms of remission according to current guidelines.
Results The surgical remission rate was 61.1%. When the patients were compared according to surgical remission, the age, gender, and immunohistochemical granulation type were found to be nonsignificant, while diabetes mellitus was more common (55.6 vs. 44.4%). The preoperative tumor volume (1.2 ± 0.9 vs. 4.1 ± 4.2 cm3) and postoperative GH and insulin-like growth factor-1 (IGF-1) levels were higher in the nonremission group (p < 0.05). We defined a number of cut-off values of both GH and IGF-1 levels to predict remission at the postoperative phase. Age standardized regression analyses showed that postoperative day 1 (POD-1) GH levels (odds ratio [OR]: 8.9; 95% confidence interval [CI]: 1.99–40.0, p = 0.004) and tumor volume (OR: 3.14; 95% CI: 1.09–9.0, p = 0.034) were found to be significant independent predictors for remission.
Conclusion We demonstrated that tumor volume and POD-1 GH levels are independent predictors of remission in acromegaly patients operated via the pure endoscopic endonasal technique and may be used as an early marker of remission, and this may lead to taking adjuvant medical therapies early into account to improve prognosis.
Manejo de fractura de platillo tibial medial utilizando placas rim anteromedial y posteromedial
Authors: Franulic Nicolás , Pineda Tomás , Valiente Diego , Laso José , Gaggero Nicolás 
Published: May 2024

Resumen
Introducción En los últimos años, se ha descrito el uso de placas horizontales para la fijación de fracturas que comprometen el reborde articular de los platillos tibiales, lo que se conoce como placa rim. La mayoría de las publicaciones al respecto describen su uso en columnas posteriores y posterolaterales de los platillos tibiales, y a la fecha hay escasos reportes del uso de este tipo de placa en la columna anteromedial y ninguno para la posteromedial. El objetivo de este artículo es presentar dos casos clínicos de fracturas conminutas del platillo tibial medial mostrando su tratamiento con el uso de placas rim.
Casos Clínicos El primer caso presentaba compromiso anteromedial y posteromedial, y el segundo, compromiso posteromedial. En ambos casos, se logró la reducción mediante un abordaje posteromedial y su fijación con placa bloqueada de 2,7 mm como placa rim. En cada caso, se detalló la estrategia de reducción y el manejo postoperatorio.
Resultados Ambos pacientes consiguieron la consolidación ósea entre las semanas 14 y 18 tras la osteosíntesis definitiva, sin presentar pérdidas de reducción. Ambos lograron rango de movilidad articular completo (0°–125°), y retornaron a sus trabajos a los 4 y 6 meses respectivamente.
Conclusiones Estas placas ofrecen una buena opción de tratamiento para fracturas articulares conminutas del borde del platillo tibial, tanto en la columna anteromedial como en la posteromedial. A pesar de la ausencia de grandes series de pacientes con uso de placas rim mediales, el resultado de los casos presentados aquí nos permite plantear su utilidad al momento de enfrentarnos a fracturas del reborde articular.
Nivel de evidencia V.
Year in Review: Synopsis of Selected Articles in Neuroanesthesia and Neurocritical Care from 2023
Authors: Hayes Sarah J. , Nijs Kristof , Venkatraghavan Lashmi 
Published: May 2024

AbstractThis review is a synopsis of selected articles from neuroscience, neuroanesthesia, and neurocritical care from 2023 (January–November 2023). The journals reviewed include anesthesia journals, critical care medicine journals, neurosurgical journals as well as high-impact medical journals such as the Lancet, Journal of American Medical Association, New England Journal of Medicine, and Stroke. The summary of important articles will serve to update the knowledge of neuroanesthesiologists and other perioperative physicians who provide care to neurosurgical and neurocritical patients.
The Effects of Ultrasonic Scaling and Air-Abrasive Powders on the Topography of Implant Surfaces: Scanning Electron Analysis and In Vitro Study
Authors: Gianfreda Francesco , Marenzi Gaetano , Nicolai Eleonora , Muzzi Maurizio , Bari Monica , Bernardini Sergio , Adamo Daniela , Miniello Alessandra , Sammartino Gilberto , Bollero Patrizio 
Published: May 2024

Abstract
Objectives This in vitro study aimed to investigate the impact of bicarbonate air-abrasive powders and ultrasonic scaling with stainless steel tips on the micro- and nanotopography and roughness of three different implant–abutment junction titanium surfaces.
Materials and Methods Three types of sterile and decontaminated titanium surfaces (RS, UTM, XA) were used for analysis. Nine disks per surface type were subjected to micro- and nanotopography analysis, scanning electron microscopy (SEM), roughness analysis, and fibroblast cultivation. Ultrasonic debridement and air polishing were performed on the surfaces. Human dermal fibroblasts were cultured on the surfaces for 5 days.
Statistical Analysis Data analysis adhered to ISO 25178 standards for surface texture assessment. SEM micrographs were used to reconstruct areas for extracting roughness parameters. Excel and Mex 6.0 software were utilized for quantitative and stereoscopic analysis.
Results The study found varying effects on surface roughness posttreatment. RS Disco samples exhibited higher surface roughness compared with UTM and XA samples, both in average and nanoscale roughness. Decontamination led to increased surface roughness for all samples, particularly RS Disco. Fibroblast growth tests revealed enhanced cell network formation on decontaminated discs, possibly due to increased nanoscale roughness or the presence of bicarbonate salts.
Conclusion The study underscores the complex interplay between surface topography, microbial biofilm, and treatment efficacy in peri-implant disease management. While smoother surfaces may resist biofilm accumulation, increased nanoscale roughness postdecontamination can enhance fibroblast attachment and soft tissue integration. This dichotomy highlights the need for tailored treatment protocols that consider material-specific factors, emphasizing that successful implant therapy should balance microbial control with conducive surface characteristics for long-term osseointegration and soft tissue stability.
Effects of Capsaicin on Migration and Alkaline Phosphatase Activity of Dental Pulp Cells
Authors: Khonglim Kittipot , Chuenjitkuntaworn Boontharika , Tamura Yukihiko , Fuangtharnthip Pornpoj 
Published: May 2024

Abstract
Objectives Dental pulp, a specialized mesenchymal tissue within teeth, is pivotal in dental health and tissue repair. Capsaicin, the primary pungent component of chili peppers, is known for its diverse pharmacological properties. While capsaicin's effects on various cell types have been studied, its impact on dental pulp cells remains relatively unexplored. This study investigated the influence of pure capsaicin extract on dental pulp cell behavior, focusing on cell viability, proliferation, migration, and alkaline phosphatase (ALP) activity.
Materials and Methods Capsaicin solution was prepared and diluted to various concentrations (1 nM, 0.01 µM, 0.1 µM, 1 µM, 10 µM, and 100 µM), then was tested on rat dental pulp cells (RPC-C2A). Cell viability and proliferation were assessed using the MTT assay. Boyden chamber tests and wound healing were used for evaluating cell migration. The activity of ALP was determined to show cell function during dental pulp repair.
Statistical Analysis The data were analyzed using a one-way analysis of variance or an independent-sample Kruskal–Wallis, followed by multiple comparison tests.
Results Capsaicin of 100 µM exhibited cytotoxicity, whereas those with lower concentrations stimulated cell proliferation. Wound healing assays revealed increased cell migration, particularly when cultured with 1 nM capsaicin (p = 0.002). Boyden chamber assays demonstrated enhanced cell invasion without statistical significance. ALP activity of dental pulp cells increased significantly at 1 nM (p < 0.001) and 1 µM (p = 0.021) capsaicin concentrations, indicating potential dentinogenesis and pulp repair.
Conclusion Capsaicin of lower concentrations, less than 10 µM, is likely to promote proliferation, migration, and ALP activity of dental pulp cells. Our findings offer potential applications for capsaicin as a medication for dental pulp repair.
Influence of Different Apical Foramen Morphologies on the Accuracy of Four Electronic Foramen Locators
Authors: Furlan Renan D. , Alcalde Murilo P. , Vivan Rodrigo R. , Klymus Michel E. , Limoeiro Ana G.S. , Duarte Marco A.H. , de Vasconcelos Bruno C. 
Published: May 2024

Abstract
Objective The aim of this study was to evaluate the accuracy of the Root ZX II (RZX), Raypex 6 (RAY), EPex Pro (EPEX), and CanalPro (CNP) electronic foramen locators (EFLs) in different foraminal morphologies (fully formed foramen, immature foramen with parallel walls, and immature foramen with divergent walls); this article also evaluated the influence of different penetration levels (0.0 mm and −1.0 mm).
Materials and Methods Thirty single-rooted human premolars were accessed and had their cervical/middle thirds prepared with SX ProTaper files. The apical foramens (AF) were standardized to 250 µm and the initial root canal length (RCL1) was measured under 16x magnification with aid of a digital caliper. Using the alginate model, electronic measurements (EM) were taken 1.0 mm up to AF (EM1/-1) and at AF (EM1/0), always using adjusted hand K-files. The root apexes were then cross-sectioned 3.0 mm from the foramen; then, new RCL (RCL2) and electronic measurements were performed (EM2/-1 and EM2/0.0). Finally, retropreparations were performed with instruments SX ProTaper files introduced 4.0 mm in the apicocervical direction. Then new RCL (RCL3) and electronic measurements (EM3/-1 and EM3/0) were performed.
Statistical Analysis Values were tabulated and tested for normality using the Shapiro–Wilk test, which yielded nonparametric distributions of the data. Data were subjected to the Kruskal–Wallis and Dunn tests to estimate possible differences between devices as a function of foramen morphology and/or apical limit. The significance level was set at 5.0%.
Results In general, the EFLs were accurate in determining the RCL. Statistically significant differences were observed between EPEX and RAY at 0.0, when measuring the divergent AF canals (p < 0.05). Regarding the different foramen morphologies in each EFL, RZX and EPEX showed no interference (p > 0.05), whereas RAY and CNP had lower accuracy levels at 0.0 with divergent AF (p < 0.05).
Conclusion The four devices evaluated are accurate to determine the RCL in the conditions tested. The apical limit of penetration did not have significant influence on their accuracy. Conversely, the presence of divergence in the AF walls negatively influenced de RAY and CNP precisions at the foraminal level.
Postimplantation Syndrome after Traumatic Internal Carotid Artery Pseudoaneurysm Repair with Stent
Authors: Romanelli Antonio , Langone Antonella , Vicinanza Veronica , Gammaldi Renato 
Published: May 2024

AbstractEndovascular repair of traumatic internal carotid artery pseudoaneurysm (TICAP) with covered stents represents a safe treatment with few complications. However, the presence of foreign material used to treat TICAP and blood clots in the excluded pseudoaneurysms can trigger an acute systemic inflammatory response syndrome called postimplantation syndrome (PIS). To the best of our knowledge, PIS is described only after abdominal aortic endovascular aneurysm repair. Here, we report the case of PIS in a young, healthy, polytraumatized female patient with TICAP treated with endovascular covered stent.
Analgesic Efficacy of Thoracolumbar Interfascial Plane Block versus Standard Care in Patients Undergoing Lumbar Spinal Surgeries—A Randomized Controlled Trial
Authors: Saini Suman , Sharma Ananya , Gupta Anju , Mankotia Dipankar S. , Boruah Tankeswar 
Published: May 2024

Abstract
Background Patients who undergo spine surgery often experience severe pain postoperatively. Multimodal analgesia inclusive of a regional block provides optimal pain relief. Thoracolumbar interfascial plane (TLIP) block may provide promising analgesia in these patients.
Materials Fifty consenting adults aged between 18 and 60 years undergoing elective lumbar spinal surgeries under balanced general anesthesia were divided into two equal groups (group T: received bilateral TLIP block, and group C: received conventional opioid analgesia). All the patients were taken care of by an independent anesthesiologist unaware of the study protocol in the postanesthesia care unit. The postoperative pain was assessed by visual analog scale (VAS). Time to first rescue analgesia, total morphine consumption, complications, and patient satisfaction were also recorded.
Results Postoperative mean VAS scores till 12 hours were significantly higher in the control group. The mean time to the first analgesic requirement among group T and group C patients was 404.4 ± 25.1 and 150.2 ± 12.4 minutes, respectively (p < 0.001). Morphine consumptions in 24 hours were also significantly higher in group C (3.36 ± 1.04 vs. 7.84 ± 1.43; p < 0.001). Mean intraoperative fentanyl consumption was significantly more in group C (122.4 ± 16.4 µg and 140.4 ± 21.7 µg; p = 0.001). Complications were similar in both groups. However, patient satisfaction was significantly higher in group T (p < 0.001).
Conclusion TLIP block provided superior analgesia, decreased opioid consumption, and improved patient satisfaction as compared with patients receiving standard general anesthesia with opioid analgesics. Hence, TLIP block could be a component of multimodal analgesia in patients undergoing lumbar spine surgeries.CTRI No.: CTRI/2021/03/031682
Incidence of Complications in Obese Patients Undergoing Elective Spine Surgery Under General Anesthesia: A Retrospective Study
Authors: Boonsombat Thanachporn , Akavipat Phuping , Suchartwatnachai Pathomporn , Sookplung Pimwan , Eiamcharoenwit Jatuporn , Chotisukarat Haruthai 
Published: May 2024

Abstract
Background The prevalence of obesity has been increasing worldwide. Simultaneously, the number of obese patients undergoing anesthesia and the risk of anesthesia-related complications are increasing. Our study aimed to identify the incidence of intraoperative anesthetic complications in obese patients undergoing elective spine surgery.
Methods Electronic medical records of patients with a body mass index (BMI) ≥ 30 kg/m2 who underwent elective spine surgery at the Neurological Institute of Thailand between January 2018 and December 2020 were retrospectively reviewed. The primary outcome was the incidence of five anesthetic adverse events: difficult intubation, oxygen desaturation, hypotension, major adverse cardiac and cerebrovascular events (MACCE), and pressure skin lesions. Logistic regression was used for statistical analysis.
Results A total of 165 obese patients' medical records were analyzed. Their mean age was 56.8 ± 11.9 years, and median BMI (interquartile range) was 32.04 kg/m2 (31.11–34.69 kg/m2). Fifty-one patients (30.9%) experienced adverse events. Six patients (3.6%) with class 3 obesity had anesthetic complications. The most common adverse event was intraoperative hypotension (26.7%), followed by pressure skin lesions (4.2%), intraoperative oxygen desaturation (1.2%), and MACCE (0.6%). No difficult intubations or deaths occurred.
Conclusion The incidence of overall intraoperative anesthetic complications in obese patients undergoing spine surgery was 30.9%, and class 3 obesity was an independent risk factor for these complications. Consequently, well-trained, vigilant, and experienced anesthesiologists should manage anesthesia in these patients.
Sexual dimorphism and reproductive biology of commercially harvested oriental rat snakes (Ptyas mucosa: Colubridae) from West Java
Authors: Hamidy Amir , Arida Evy , Maireda Noor Laina , Herlambang Alamsyah Elang Nusa , Riyanto Awal , Mumpuni  , Shine Richard , Natusch Daniel J. D. 
Published: May 2024

Large (>3 m) slender-bodied rat snakes are abundant in agroecosystems of southern Asia and are heavily exploited for their skins and meat. We examined 216 specimens killed at commercial facilities in Cirebon, West Java, to quantify morphological and reproductive traits and evaluate harvest sustainability by comparing this sample to one taken 25 years previously. The snakes we examined were mostly adults, and mostly male. Females were less heavy-bodied than males of the same body length, matured at a larger size than males, but attained smaller maximum sizes. Reproduction and energy (fatbody) storage was seasonal in both sexes, with females containing oviductal eggs primarily during the annual wet season. Clutch size averaged 12.6 eggs and increased with maternal body size. Comparison of the two samples taken 25 years apart revealed strong similarity in sex ratio, the numerical preponderance of adults, body sizes at sexual maturation and mean adult body sizes, sexual dimorphism in body length and mass, reproductive seasonality in females, mean fecundity, and the relationship between fecundity and maternal body size. That consistency suggests that commercial harvesting over the intervening period has not affected the biological traits of rat snake populations, consistent with a sustainable level of offtake.
Air pollution mortality from India’s coal power plants: unit-level estimates for targeted policy
Authors: Singh Kirat , Peshin Tapas , Sengupta Shayak , Thakrar Sumil K , Tessum Christopher W , Hill Jason D , Azevedo Inês M L , Luby Stephen P 
Published: May 2024

Abstract
Air pollution from coal-fired electricity generation is an important cause of premature mortality in India. Although pollution-related mortality from the sector has been extensively studied, the relative contribution of individual coal-fired units to the fleet-wide mortality burden remains unclear. Here, we find that emissions from a small number of units drive overall mortality. Units producing just 3.5% of total generation and constituting less than 3% of total capacity result in 25% of annual premature mortality from coal-fired generation. This is a direct consequence of the 200-fold variation that we find in the mortality intensity of electricity generation across units. We use a detailed emissions inventory, a reduced complexity air quality model, and non-linear PM2.5 concentration-response functions to estimate marginal premature mortality for over 500 units operational in 2019. Absolute annual mortality ranges from less than 1 to over 650 deaths/year across units, and the mortality intensity of generation varies from under 0.002 to 0.43 deaths/GWh. Our findings suggest the potential for large social benefits in the form of reduced PM2.5-related premature mortality in India if the highest mortality intensity units are prioritized for the implementation of pollution control technologies or accelerated retirement.
Synthesis and characterisation of Cu2Ge, a new two-dimensional Dirac nodal line semimetal
Authors: Cameau Mathis , Olszowska Natalia , Rosmus Marcin , Silly Mathieu G , Cren Tristan , Malecot Axel , David Pascal , D’angelo Marie 
Published: May 2024

Abstract
Dirac nodal line (DNL) semimetals are a novel class of topological materials in which the valence and conduction bands touch along lines in the reciprocal space, with linear dispersion. These materials attract a growing attention, but the experimental realizations for two-dimensional systems are sparse. This article reports the first experimental realization of a two-dimensional hexagonal monolayer Cu2Ge, grown by evaporation of Ge on a Cu(111) substrate. Through a combination of low-energy electron diffraction XPS and ARPES measurements, it is shown that the surface presents all characteristics expected from calculations for a free-standing Cu2Ge monolayer. More specifically, the preservation of the two concentric nodal lines around the Γ point indicates weak interactions between the Cu2Ge surface and its Cu(111) substrate, making it an ideal system for the study of DNL materials.