bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary investigation into the genetic etiology of short stature in children through whole exon sequencing of the core family
Authors: He Jinshui , Zhang Shuyun , Kang Yueya , Zhang Yugui , Zheng Zhugui , Ruan Minyi 
Published: May 2024

Abstract
A comprehensive survey was carried out to investigate the genetic etiology of short stature in children by whole exon sequencing of a core family cohort to find and study mutations in multiple genes to assess their potential correlations to low height in children. The study included 56 pediatric patients from the Department of Pediatrics at the Zhangzhou Affiliated Hospital of Fujian Medical University. The participants met strict inclusion criteria, including age, Han Chinese ethnicity, low height standard deviation score, and the absence of known causes for short stature. Core pedigrees were identified using exome sequencing. After sequencing, variations were categorized and interpreted according to a variety of factors, including inheritance, location, type, and disease-causing gene databases. Variants were verified by Sanger sequencing. Most of the 97 gene mutations were missense. ACAN, PHEX, and COL2A1 were the most common gene mutations. Copy number variations were identified, particularly associated with the PHEX gene. Protein functional studies revealed that the mutations had a considerable influence on disease-promoting damage. The chromosomal locations with the highest enrichment of these genes were chr12, chr5, and chr2. In conclusion, the study revealed numerous genetic changes that may substantially impact physiological processes and disease. These findings establish the basis for further investigations into their diagnostic and therapeutic capabilities.
Japanese EFL undergraduate students’ use of the epistemic modal verbs may, might, and could in academic writing
Authors: Hollmann Willem B. , Fujimoto Kazuko , Kuroda Masahiro 
Published: May 2024

Abstract
Modifying and hedging one’s claims appropriately is an important characteristic of academic writing. This study focuses on the three main English modal verbs used to express “epistemic possibility” to avoid making strong statements, viz., may, might, and could. The purpose of this corpus-based study is to explore modal verb usage by Japanese EFL undergraduate students and consider pedagogical implications of our findings. Our analysis suggests that the Japanese students’ use of these modal verbs, especially could, has a tendency to be informal and insufficiently academic. While the Japanese students use could very frequently, they do not use it sufficiently in the sense of “epistemic possibility”, and some of their use is inappropriate not just in academic English but in English more generally. The observed high frequency of could may be related to topics and may also be due to the influence of L1. We discuss different factors that may explain the findings, based mainly on the overview of factors impacting on EFL learners’ use of academic English offered by Gilquin and Paquot (2008). Too chatty: Learner academic writing and register variation. English Text Construction 1(1). 41–61), suggest several additions to this overview, and discuss implications for the instruction of these modal verbs in academic writing and in order to improve relevant teaching materials.
Das Nacaps-Datenportal – Potenziale, Besonderheiten und Datenqualität in interaktiven digitalen Reportings
Authors: Azeroual Otmane 
Published: May 2024

Zusammenfassung
Die Veröffentlichung von Forschungsaktivitäten und -ergebnissen sowie die verschiedenen Beteiligten stellen den Datenaustausch, die Exploration und die Visualisierung vor große Herausforderungen. Für die vom Bundesministerium für Bildung und Forschung (BMBF) geförderte National Academics Panel Study (Nacaps) hat das Deutsche Zentrum für Hochschul- und Wissenschaftsforschung (DZHW) ein offenes Datenportal entwickelt. Mit interaktiven Grafiken zu Themen wie Promotionsbedingungen, Karriereabsichten, Mobilität oder Finanzierung bietet das Portal einen Überblick zur Lebens- und Arbeitsrealität Promovierender in Deutschland. Befragungsdaten werden im Datenportal so aufbereitet, dass sie niedrigschwellig verwendbar sind. Da die Daten in offenen und wiederverwendbaren Formaten ohne Einschränkung unentgeltlich zur Verfügung gestellt werden, können sie gleichermaßen von der Forschung und der Öffentlichkeit genutzt werden. Zugleich bietet das Portal kooperierenden Partnerhochschulen in einem geschützten Raum eine hochschulspezifische Berichterstattung über die Daten von Promovierenden ihrer Einrichtung. Erörtert werden die mögliche Weiterentwicklung und effektiven Nutzung des Nacaps-Datenportals für das Management von offenen Befragungsdaten. Dabei werden besonders die Qualität offener Befragungsdaten sowie das Potenzial und die Besonderheiten des Nacaps-Datenportals bei der Visualisierung von Befragungsdaten diskutiert.
On the construction of various soliton solutions of two space-time fractional nonlinear models
Authors: Tariq Kalim U. , Liu Jian-Guo 
Published: May 2024

Abstract
In this article, we investigate a couple of nonlinear fractional models of eminent interests subsequently the conformable derivative sense is used to designate the fractional order derivatives. The given structures are transformed into nonlinear ordinary differential equations of integer order, and the extended simple equation technique is then employed to solve the resulting equations. Initially, the nonlinear space time fractional Klein–Gordon equation is considered emerging from quantum and classical relativistic mechanics, which have application in plasma physics, dispersive wave phenomena, quantum field theory, and optical fibres. Later, the (2 + 1)-dimensional time fractional Zoomeron equation is analysed which is convenient to explore the innovative phenomena related to boomerons and trappons. As a result, various new soliton solutions are successfully established. The reported results offer a key implementation for analysing the soliton solutions of nonlinear fractional models which are extremely encouraging arising in the recent era of science and engineering. The 3D simulations have been carried out to demonstrate dynamics of the various soliton solutions for a given set of parameters.
Verified of leakage loss, birefringence, nonlinear parameters and total number of modes in silica/silica doped and plastic fibers for fiber system efficiency improvement
Authors: Prabu Ramachandran Thandaiah , Santhakumar Dhilipkumar , Kumar Ata Kishore , Lalitha Sangeetham Dharuman , Jebanazer Jeneetha , Mohan Salem Balamurugan , Ahmed Aisha abd Rahman 
Published: May 2024

Abstract
This paper has clarified verified of leakage loss, birefringence, nonlinear parameters and total number of modes in silica/silica doped and plastic fibers for fiber system efficiency improvement. The signal power loss is demonstrated with silica/silica doped/plastic fibers at various ambient temperatures. The estimated number of fiber modes is clarified in the core against silica/silica doped/plastic fiber core radius. The fiber birefringence is studied against silica/silica doped/plastic fiber core radius. The silica/silica doped/plastic fibers effective refractive index is clarified versus ambient temperature variations. The nonlinear parameter is demonstrated based silica doped fiber against the dopant concentration ratio with different temperature variations. The effective area cross section is studied based silica doped fiber against the dopant concentration ratio with different temperature variations. The predicted fiber loss is demonstrated against the fiber operating wavelength for silica glass fibers/silica doped fibers/plastic fibers. As well as the predicted fiber loss is clarified and studied versus fiber core radius for silica glass/silica doped/plastic fibers.
Biomedical and therapeutic potential of marine-derived Pseudomonas sp. strain AHG22 exopolysaccharide: A novel bioactive microbial metabolite
Authors: Aloraini Ghfren S. , Albureikan Mona Othman I. , Shahlol Aisha M. A. , Shamrani Taghreed , Daghistani Hussam , El-Nablaway Mohammad , Tharwat Nagwa A. , Elazzazy Ahmed M. , Basyony Ahmed F. , Ghareeb Ahmed 
Published: May 2024

Abstract
Microbial exopolysaccharides (EPSs) are gaining interest as alternatives to chemical antioxidants and pharmaceuticals. This study mines the promising biomedical and antimicrobial potential of a marine bacterium, a prolific EPS producer, isolated from the Red Sea. Pseudomonas sp. strain AHG22 generated an EPS weighing 6.98 g·L−1, coded EPSF8, subjected to FT-IR and HPLC chemical analysis. EPSF8 was then investigated for antioxidant assessment by 2,2-diphenyl-1-picrylhydrazyl (DPPH), H2O2, ABTS˙
+
, nitric oxide, total antioxidant capacity (TAC), and ferric reducing antioxidant power (FRAP). EPSF8 had an IC50 of 46.99 μg·mL−1 in the DPPH antioxidant assay and antioxidant capacities of 219.45 μg·mg−1 ascorbic acid equivalent (AAE) in the TAC assay and 54.15 μg·mg−1 AAE in the FRAP assay. The in vitro anti-inflammatory effect of EPSF8 was tested against 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) enzymes and compared with the drugs ibuprofen and celecoxib used as controls. The IC50 values of 5-LOX, COX-2, ibuprofen, and celecoxib were found to be 14.82, 15.49, 1.5, and 0.28 μg·mL−1, respectively. Additionally, EPSF8 revealed antidiabetic activity toward α-amylase and α-glucosidase, and the IC50 values were 93.1 and 127.28 μg·mL−1, compared to those of acarbose (50.93 and 4.13 μg·mL−1, respectively). Anti-obesity activity of EPSF8 by lipase inhibition revealed IC50 = 56.12 μg·mL−1 compared to orlistat (IC50 = 20.08 μg·mL−1) as a control. EPSF8 displayed antibiofilm and bactericidal activity against Gram-positive (G +ve) and Gram-negative (G −ve) ATCC pathogenic bacterial strains. It had a minimum bactericidal concentration/minimum inhibitory concentration ratio ≤2, indicating a broad bactericidal spectrum. Furthermore, EPSF8 is evidenced to have a promising anti-butyrylcholinesterase activity for the control of Alzheimer’s disease. The findings of the present analysis suggest that the isolated Pseudomonas sp. strain AHG22 EPS can potentially be explored as a promising green therapeutic compound.
Physical activity with person-centered guidance supported by a digital platform or with telephone follow-up for persons with chronic widespread pain: Health economic considerations along a randomized controlled trial
Authors: Gyllensten Hanna , Larsson Anette , Bergenheim Anna , Barenfeld Emmelie , Mannerkorpi Kaisa 
Published: May 2024

Abstract

Objectives
The aim was to investigate the resource use and costs associated with the co-creation of a physical activity plan for persons with chronic widespread pain (CWP) followed by support through a digital platform, compared to telephone follow-up.

Methods
In this 12-month cost comparison study following up results after a randomized controlled trial, individuals with CWP, aged 20–65 years, were recruited at primary healthcare units in Western Sweden. All participants developed a person-centered health-enhancing physical activity plan together with a physiotherapist. Participants were then randomized to either an intervention group (n  =  69) who had a follow-up visit after 2 weeks and was thereafter supported through a digital platform, or an active control group (n  =  70) that was followed up through one phone call after a month. Costs to the health system were salary costs for the time recorded by physiotherapists when delivering the interventions.

Results
The reported time per person (2.8 h during the 12 months) corresponded to costs of SEK 958 (range: 746–1,517) for the initial visits and follow-up (both study groups), and an additional 2.5 h (corresponding to a mean SEK 833; range: 636–1,257) for the time spent in the digital platform to support the intervention group.

Conclusion
After co-creation of a physical activity plan, it was more costly to support persons through a digital platform, compared to telephone follow-up.
ChatGPT from the students' point of view – Lessons from a pilot study using ChatGPT in business higher education
Authors: Kétyi András , Géring Zsuzsanna , Dén-Nagy Ildikó 
Published: May 2024

AbstractIn a recent pilot study, we examined the potential benefits and opportunities that ChatGPT can bring to higher education, particularly from the perspective of business students and educators. The study included 41 participants and aimed to explore their opinions on using ChatGPT in business language classes. Twelve students did not use ChatGPT during the course (control group), while 29 students used it actively (experimental group). Examining their experiences and comparing the two groups, it is evident that students see the benefits and disadvantages of ChatGPT and use it for tasks they find helpful. However, the practice and hands-on experience helped the experimental group members gain much more diverse and nuanced opinions about ChatGPT. These results underline that universities and their boards must embrace the technology and find reasonable areas to use ChatGPT. These may not only be connected to assignment forms and plagiarism, but can embrace more general topics, like equal eligibility to these new technologies or strengthening the students' social and emotional intelligence and skills to help their future lives.
Development of nursing learning program for COVID-19 patients with e-learning method for nursing department students Poltekkes Ministry of Health Jayapura Papua
Authors: Maryorita Blestina , Maay Jems Kifen Roget 
Published: May 2024

Introduction: In the COVID-19 pandemic, educational institutions must align learning programs with advances in information technology and conditions of COVID-19. Knowledge about COVID-19 nursing care is also very much needed, especially for students majoring in Nursing.One of the media suitable for current conditions is e-learning, which can have a positive effect because students can study independently anytime and anywhere. The-learning method has more independence. Some experts believe that in learning, learner autonomy and self-determination are important. This research method uses the ADDIE Model. This study aims to investigate the problems and needs of the learning program in nursing care COVID-19 and to respond to the Nursing care learning program for COVID-19 disease.
Method: The research was conducted at the nursing department of Jayapura Health Polytechnic. Data collection techniques using questionnaires and observation sheets. The data were analyzed using quantitative descriptive, namely changing the quantitative data from the results of product validation and testing into qualitative data based on the criteria for the validity and feasibility of the product. The ADDIE model stages consist of five steps: analysis, design, development or production, implementation and evaluation.
Result: The results showed that 78.2% of COVID-19 nursing care learning was inadequate, and 82% indicated the need for COVID-19 nursing care learning. The expert team's assessment of program development is averaging 81.6% with valid criteria. The results of product trials in the small group obtained an average result of 81.11% with very good criteria. While the results of product trials in the large group were 81.26% with very good criteria.
Conclusion: The results of the COVID-19 nursing care learning program using e-learning were developed through the stages of analysis, design, development, trial and evaluation. It is necessary to test the product to produce an up-to-date program. The development of COVID-19 nursing care learning programs using e-learning makes it easier to understand and be able to achieve the competencies expected in the COVID-19 pandemic situation.
Skin graft as a modality reconstruction of post-burn contractures during pandemic area: case series
Authors: Elfiah Ulfa , David Sontani Perdanakusuma  , Iswinarno Dososaputra  , I Nyoman Riasa  , Lumintang Loelita Marcelia , Naufal Muhammad Fahmi 
Published: May 2024

Background: The Covid-19 pandemic causes the postponement of elective surgery. At the same time, patients with post-burn contractures require immediate operation due to impaired function that can lead to depression and disruption of daily life. Operations on contracture patients during a pandemic must be carried out using the principles of accuracy, speed, and safety. The skin graft is one of the most appropriate treatments modalities for releasing contractures. This case study aims to evaluate the skin graft as a modality reconstruction of post-burn contractures during pandemic area.
Case Presentation: We present three cases of post-burn contractures who underwent contracture release and skin graft surgery with a hospital stay of 3-5 days. Surgical results showed that graft take reached 90%-100% in all patients, and 100% epithelialization occurred at donor sites between 2-4 weeks postoperatively. There were no post-operative complications.
Conclusion: The skin graft is an effective and suitable technique for treating post-burn contractures in the pandemic era.
Prevalence of multidrug-resistant Escherichia coli isolated from Jember hospital food handler in Indonesia
Authors: Suswati Enny , Supangat  , Indreswari Laksmi , Nur U’alifa Farhatina , Nabila Faiza , Inas Gama Putri Hertian  
Published: May 2024

Introduction: Foodborne illness is a significant global public health issue. Improper food handling and personal cleanliness can result in a few ailments. Over 400 food-related infections have been found by the CDC, of which food handlers cause 20%. Escherichia coli is often found in hospital food handler hand and nasal swabs. This study aimed to ascertain the prevalence of E. coli and the antibiotic susceptibility profile of food handlers working in hospitals in Jember City, Indonesia.
Method: A cross-sectional investigation uses a total sampling method held between October and November 2022. Inclusion criteria are asymptomatic food handlers that have not taken antibiotics for the last three months and have already given informed consent. Exclusion criteria are food handlers who’s sick or with incomplete questionnaires. We performed hand and nasal swabs and continued with bacteria identification, culture, and antibiotic sensitivity tests.
Result: Ten food workers (14.71%) and fourteen (20.59%) of the 68 who underwent hand and nasal swab culture screenings for E. coli were positive. All E. coli hand swab isolates were susceptible to levofloxacin and azithromycin antibiotics. Still, of the 10 E. coli hand swab isolates, 90% were resistant to the antibiotics; penicillin, Cefotaxime, and ceftriaxone, while 70% were resistant to erythromycin. For E. coli isolates originating from nasal swabs, 85.71% were resistant to Cefotaxime, 71.43% to Penicillin and Cefepime, and 57.14% were resistant to Ceftriaxone and Erythromycin. E. coli Multiple Antibiotic Resistance (MAR) index for hand and nasal swab specimens is 0.18 – 0.82. Most of the hand swab specimens (90%) are Multidrug Resistant (MDR), while nasal swab specimen shows 78.57% Multidrug Resistant (MDR).
Conclusion: The predominance of multidrug-resistant E. coli among hospital food handlers makes it imperative to implement infection control measures, including better biosecurity, to ensure that they do not enter the food supply and limit alternatives to inpatient therapy.
Research gap and trend in neurological therapy related to nanotechnology based on bibliometric analysis
Authors: Saleh Arman Yurisaldi , Valentina Riezky 
Published: May 2024

Link of Video Abstract: https://youtu.be/3n_K49-K4jM

Introduction: The development of nanotechnology science is so fast that there has been a lot of progress in terms of therapeutic research related to diseases in Neurology. To our knowledge, there have been no bibliometric studies in this field, so this study is needed to see research gaps that world researchers can do to accelerate and multiply nanotechnology that can be applied in patient therapy in clinics and collaborate with existing researchers in this field. This research aims to look for gaps in research fields that have not been widely studied in the field of nanotechnology related to neurological diagnosis and therapy and know research trends.
Method: Documents were collected from the Scopus site from 2002 to 2022, totaling 245 documents, which were then analyzed quantitatively with Biblioshiny and Vosviewer software. Furthermore, a qualitative analysis was also carried out.
Results: Gathered information on document trends, citation counts, authors, producing nations, affiliations, research topics, and research networks. Three developing domains (niches) are three developing domains (niches) that present research opportunities for researchers worldwide. The United States seems to be the industry leader in document production.
Conclusion: The politics of a nation's financing policies heavily influence the advancement of research in the field of nanotechnology connected to the diagnosis and treatment of neurological illnesses. In order to expedite and replicate applications in the therapeutic use of nanotechnology, establishing new international research networks is required. Research gaps might be found through this research.
Predictors of neonatal mortality with congenital heart disease
Authors: Pradnya Paramita Made Indah , Gunawijaya Eka , Yantie Ni Putu Veny Kartika , Kardana Made 
Published: May 2024

Link of Video Abstract : https://youtu.be/Vi3785NsB1A

Introduction: Congenital heart disease (CHD) is the leading cause of birth defect-associated infant illness and death. In developing countries, the mortality related to CHD increased by up to 25%, but the data about predictors of mortality are limited. The purpose of this study was to investigate the predictors of mortality in neonates with CHD.
Methods: We conducted a case-control study of neonatal mortality with CHD from January 2018 to October 2022. Data were collected from the neonatal registry in Prof Ngoerah Hospital, Bali. Characteristics and clinical risk of mortality were analyzed. Chi-square and logistic regression analysis was carried out to determine the potential predictor of mortality.
Results: A total of 288 neonatal with CHD were analyzed. Neonatal morbidities such as extremely low birth weight (ELBW) were found in 7.6%, asphyxia in 50.7%, multiple congenital anomalies (MCA) in 13.2%, pulmonary hypertension (PH) in 13.5%, sepsis in 66.3%, and severe form of CHD in 50.7%. Patent ductus arteriosus (PDA) was the most acyanotic CHD (35%). Mortality resulting from CHD was 27%. ELBW, severe and moderate asphyxia, MCA, PH, sepsis, and severe form of CHD were significant mortality predictors (p<0.05) with (OR; 95%CI) were (6.21; 1.24-31.12), (4.13; 1.93-8.81), (3.20;1.69-6.08), (2.70; 1.17-6.24), (2.54;1.10-5.84), (2.33; 1.28-4.22), (2.00; 1.15-3.49) respectively.
Conclusion: ELBW, severe and moderate asphyxia, MCA, PH, sepsis, and severe forms of CHD are predictors of neonatal mortality with CHD.