bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease
Authors: Quiroz Yakeel T. , Budson Andrew E. , Celone Kim , Ruiz Adriana , Newmark Randall , Castrillón Gabriel , Lopera Francisco , Stern Chantal E. 
Published: December 2010

AbstractObjectiveThe examination of individuals who carry fully penetrant genetic alterations that result in familial Alzheimer's disease (FAD) provides a unique model for studying the early presymptomatic disease stages. In AD, deficits in episodic and associative memory have been linked to structural and functional changes within the hippocampal system. This study used functional MRI (fMRI) to examine hippocampal function in a group of healthy, young, cognitively‐intact presymptomatic individuals (average age 33.7 years) who carry the E280A presenilin‐1 (PS1) genetic mutation for FAD. These PS1 subjects will go on to develop the first symptoms of the disease around the age of 45 years. Our objective was to examine hippocampal function years before the onset of clinical symptoms.MethodsTwenty carriers of the Alzheimer's‐associated E280A PS1 mutation and 19 PS1‐negative control subjects participated. Both groups were matched for age, sex, education level, and neuropsychological test performance. All participants performed a face‐name associative encoding task while in a Phillips 1.5T fMRI scanner. Analysis focused on the hippocampal system.ResultsDespite identical behavioral performance, presymptomatic PS1 mutation carriers exhibited increased activation of the right anterior hippocampus during encoding of novel face‐name associations compared to matched controls.InterpretationOur results demonstrate that functional changes within the hippocampal memory system occur years before cognitive decline in FAD. These presymptomatic changes in hippocampal physiology in FAD suggest that hippocampal fMRI patterns during associative encoding may also provide a preclinical biomarker in sporadic AD. ANN NEUROL 2010
Synthesis and photovoltaic properties of dithienyl benzotriazole based poly(phenylene vinylene)s
Authors: Zhang Zhenhua , Peng Bo , Ding Ping , Liu Bo , He Yuehui , Zhou Kechao , Li Yongfang , Pan Chunyue , Zou Yingping 
Published: December 2010

AbstractTwo new alternating copolymers based on dithienyl benzotriazole segment and phenylene vinyl unit were synthesized by Heck cross coupling method. The polymers exhibited broad absorption bands (from 300 nm to 752 nm for P1, and from 300 nm to 654 nm for P2) in the UV‐visible region with optical bandgap ranging between 1.6 and 1.9 eV and proper electronic energy levels measured by cyclic voltammetry. The photovoltaic properties of the polymers as electron donors with 6.6‐phenyl C61‐butyric acid methyl ester as the electron acceptor in a bulk heterojunction structures were reported. Preliminary results showed moderate power conversion efficiency of 0.36% and 0.4%, respectively, under the illumination of AM 1.5, 100 mW/cm2 with a device structure of ITO/PEDOT : PSS/polymer : PC60BM (1 : 3)/Ca/Al. Furthermore, the side chain effect on properties has also been investigated. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Optimized formulation of an oxidative curing system for liquid polysulfide sealants used in fuel tanks by D‐optimal design method
Authors: Rezaeian Iraj , Zahedi Payam , Rezaeian Ali , Ghadiri Maryam , Honarvar Faraz Mohammadzadeh , Mohammadi Amir Hossein 
Published: December 2010

AbstractIn this work, the effective parameters in liquid polysulfide curing system were optimized by D‐optimal design method. Five main components in the formulation, carbon black, vulcanizing agents (MnO2, Na2Cr2O7, and PbO2), CaCO3, fumed silica, and chlorinated paraffin, were selected. Mechanical and chemical properties of the samples were investigated. The results showed that tensile strength, hardness, viscosity, and optimum cure time (t90) presented a suitable coordination with reduced quadratic model. For elongation at break and swelling tests, reduced two‐factor interaction (2FI), and for peel strength, a linear model showed the best correlation. To achieve the desirable properties for liquid polysulfide sealants used in fuel tanks, an optimized amount of the above components in the formulation were used. Finally, MnO2 curing system, compared with Na2Cr2O7 and PbO2, was selected as the best choice. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Vinyl triazole carrying metal‐chelated beads for the reversible immobilization of glucoamylase
Authors: Kök Senay , Osman Bilgen , Kara Ali , Beşirli Necati 
Published: December 2010

AbstractPoly(ethylene glycol dimethacrylate–1‐vinyl‐1,2,4‐triazole) [poly(EGDMA–VTAZ)] beads with an average diameter of 100–200 μm were obtained by the copolymerization of ethylene glycol dimethacrylate (EGDMA) with 1‐vinyl‐1,2,4‐triazole (VTAZ). The copolymer hydrogel bead composition was determined by elemental analysis and was found to contain 5 EGDMA monomer units for each VTAZ monomer unit. The poly(EGDMA–VTAZ) beads were characterized by swelling studies and scanning electron microscopy (SEM). The specific surface area of the poly(EGDMA–VTAZ) beads was found 65.8 m2/g. Cu2+ ions were chelated on the poly(EGDMA–VTAZ) beads. The Cu2+ loading was 82.6 μmol/g of support. Cu2+‐chelated poly(EGDMA–VTAZ) beads with a swelling ratio of 84% were used in the immobilization of Aspergillus niger glucoamylase in a batch system. The maximum glucoamylase adsorption capacity of the poly(EGDMA–VTAZ)–Cu2+ beads was 104 mg/g at pH 6.5. The adsorption isotherm of the poly(EGDMA–VTAZ)–Cu2+ beads fitted well with the Langmuir model. Adsorption kinetics data were tested with pseudo‐first‐ and second‐order models. The kinetic studies showed that the adsorption followed a pseudo‐second‐order reaction model. The Michaelis constant value for the immobilized glucoamylase (1.15 mg/mL) was higher than that for free glucoamylase (1.00 mg/mL). The maximum initial rate of the reaction values were 42.9 U/mg for the free enzyme and 33.3 U/mg for the immobilized enzyme. The optimum temperature for the immobilized preparation of poly(EGDMA–VTAZ)–Cu2+–glucoamylase was 65°C; this was 5°C higher than that of the free enzyme at 60°C. The glucoamylase adsorption capacity and adsorbed enzyme activity slightly decreased after 10 batch successive reactions; this demonstrated the usefulness of the enzyme‐loaded beads in biocatalytic applications. The storage stability was found to increase with immobilization. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Characteristics and iso‐baric relaxation phenomenon of pmma monolayers with different molecular weights at different temperatures
Authors: Jheng Kai‐Teng , Hsu Wen‐Ping 
Published: December 2010

AbstractPoly(methyl methacrylate) (PMMA) monolayers with different molecular weights at the air/water interface were investigated at three different temperatures. The monolayer characteristics of PMMA were studied in terms of surface pressure‐area per molecule (π‐A) isotherm and isobaric relaxation experiments. The results show that the π‐A isotherms of PMMA converge at 40°C regardless of molecular weight. The collapse pressure of PMMA monolayers decreases as the temperature is elevated. It was shown the area relaxation process of PMMA could be described by a model considering the nucleation and growth mechanisms. The simulation parameters of area relaxation of PMMA with different molecular weights at 8 mN/m are very similar, indicating similar mechanisms. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
A simple Suboptimal siphon‐based control model of a well‐known S3PR
Authors: Chao Daniel , Liu Guan Jun 
Published: December 2010

AbstractSiphon‐based deadlock control suffers from reaching fewer states than the maximally permissive one. We report an alternative control to reach the same good states as that based on the theory of regions, but with fewer monitors, by refining some monitors into several monitors with smaller controller regions. More states can be reached since the controller region is less disturbed by covering only a place in a subregion where only one place is marked at any reachable marking. Formal proof of the correctness is provided.Copyright © 2010 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society
ILSI/HESI maternal toxicity workshop summary: maternal toxicity and its impact on study design and data interpretation
Authors: Beyer Bruce K. , Chernoff Neil , Danielsson Bengt R. , Davis‐Bruno Karen , Harrouk Wafa , Hood Ronald D. , Janer Gemma , Liminga Ulla Wändel , Kim James H. , Rocca Meredith , Rogers John , Scialli Anthony R. 
Published: December 2010

AbstractWorkshops on maternal toxicity were held at the annual Society of Toxicology, Teratology Society, and European Teratology Society meetings in 2009. Speakers presented background information prior to a general discussion on this topic.The following recommendations/options are based on the outcome of the discussions at the workshops:

A comprehensive evaluation of all available data from general toxicity studies, range‐finding Developmental and Reproductive Toxicology (DART) studies, class effects, structure–activity relationships, exposure studies, etc. is essential for appropriate dose selection for definitive DART studies. The intent is to avoid marked maternal toxicity leading to mortality or decreased body weight gains of greater than 20% for prolonged periods.

Evaluate alternative endpoints for dose selection and data interpretation (e.g., target tissue effects and pharmacology) for biotherapeutics.
Evaluate additional maternal parameters based on effects and/or target organs observed in short‐term (e.g., 2‐ or 4‐week) general toxicity studies.

Evaluate all available data to determine a cause–effect relationship for developmental toxicity.

Conduct a pair‐feeding/pair‐watering study as a follow‐up.
Evaluate individual data demonstrating maternal toxicity in the mother with adverse embryo–fetal outcomes in the litter associated with the affected mother.
Conduct single‐dose studies at increasing doses as a complement to conventional embryo–fetal toxicity studies for certain classes of compounds that affect the hERG channel.

Support statements that embryo–fetal effects are caused by maternal toxicity and/or exaggerated pharmacology, especially for malformations.

Provide mechanistic or other supporting data.
Establish the relevance of the DART findings in animals for human exposures. Birth Defects Res (Part B) 92:36–51, 2010. © 2011 Wiley‐Liss, Inc.
Oscillating chemiluminescence systems: state of the art
Authors: Iranifam Mortaza , Segundo Marcela A. , Santos João L. M. , Lima José L. F. C. , Sorouraddin Mohammad H. 
Published: December 2010

AbstractThis month's featured article; ‘Oscillating chemiluminescence systems: state of the art’ is authored by Mortaza Iranifam, Marcela A. Segundo, João L. M. Santos, José L. F. C. Lima and Mohammad H. Sorouraddin.In this review, the authors present the first comprehensive account of the developments and current state of the art regarding Oscillating chemiluminescent systems. From Belousov–Zhabotinskii and horseradish peroxidase‐catalyzed reactions through to Orban oscillators and more. This report pulls together many important developments in the field that have previously only been available scattered across periodicals and diff erent media.The cover image is a graphical representation of a biological Belousov–Zhabotinskii reaction composited against the oscillating CL behavior for 1,10‐phenanthroline–H2O2–KSCN–CuSO4–NaOH system in a batch reactor.
DNA and chromatin imaging with super‐resolution fluorescence microscopy based on single‐molecule localization
Authors: Flors Cristina 
Published: December 2010

AbstractWith the expansion of super‐resolution fluorescence microscopy methods, it is now possible to access the organization of cells and materials at the nanoscale by optical means. This review discusses recent progress in super‐resolution imaging of isolated and cell DNA using single‐molecule localization methods. A high labeling density of photoswitchable fluorophores is crucial for these techniques, which can be provided by sequence independent DNA stains in which photoblinking reactions can be induced. In particular, unsymmetrical cyanine intercalating dyes in combination with special buffers can be used to image isolated DNA with a spatial resolution of 30–40 nm. For super‐resolution imaging of chromatin, cell permeant cyanine dyes that bind the minor groove of DNA have the potential to become a useful alternative to the labeling of histones and other DNA‐associated proteins. Other recent developments that are interesting in this context such as high density labeling methods or new DNA probes with photoswitching functionalities are also surveyed. Progress in labeling, optics, and single‐molecule localization algorithms is being rapid, and it is likely to provide real insight into DNA structuring in cells and materials. © 2010 Wiley Periodicals, Inc. Biopolymers 95: 290–297, 2011.
Learning motivational interviewing in a real‐life setting: A randomised controlled trial in the Swedish Prison Service
Authors: Forsberg Lars , Ernst Denise , Farbring Carl Åke 
Published: December 2010

ABSTRACTBackground Motivational interviewing (MI) is a client‐centred, directive counselling style for helping people to explore and resolve ambivalence about behaviour change and shown to decrease drug and alcohol use. A five‐session semi‐structured MI intervention [Beteende, Samtal, Förändring (BSF; Behaviour, Counselling, Change)] was implemented in Swedish prisons.Aims To examine whether, in a real‐life implementation of semi‐structured MI, staff receiving ongoing MI training, based on audio‐recorded feedback in peer groups (BSF+), possess greater MI skill compared with staff receiving workshop‐only MI training (BSF), and staff conducting usual prison planning interviews (UPI).Methods Prisoners were randomised to one of the three interventions. The first sessions between staff and prisoner with complete data were assessed with the Motivational Interviewing Treatment Integrity Code 3.0.Results Content analysis of 45 staff: prisoner sessions revealed that counsellors in the BSF+ group were significantly more competent in MI than those in the UPI group, but there was no difference in MI competency between the BSF and UPI groups. Overall, staff were rated as not having achieved beginning proficiency.Conclusions Our findings suggest that staff delivering motivational interviewing programmes for substance‐misusing prisoners in Sweden are not being given sufficient training for the task. Previous literature has suggested that staff need more than a basic 3‐ to 5‐day workshop training, but our findings suggest that they may need longer‐term continuing supervision and support than previously recognised. Copyright © 2010 John Wiley & Sons, Ltd.
Silica‐Supported Gold Nanoparticles Catalyzed One‐Pot, Tandem Aerobic Oxidative Cyclization Reaction for Nitrogen‐Containing Polyheterocyclic Compounds
Authors: So Man‐Ho , Liu Yungen , Ho Chi‐Ming , Lam Kar‐Yee , Che Chi‐Ming 
Published: December 2010

AbstractA silica‐supported gold nanoparticle catalyst AuNPs/SiO2 (A) has been prepared by deposition of in situ synthesized gold nanoparticles (AuNPs) onto the surface of silica. A simple method that uses A as the catalyst and oxygen as the oxidant is effective for oxidative cyclization of anilines with aldehydes to form quinolines in a one‐pot reaction (20 examples; product yields up to 95 %). The “AuNPs/SiO2+O2” protocol is applicable to the synthesis of nitrogen‐containing polyheterocyclic compounds in good to excellent product yields by using bulky polycyclic anilines as the starting materials (10 examples; product yields up to 96 %). The A catalyst can be easily recovered by centrifugation and reused for seven consecutive runs without significant loss of catalytic activity.
ChemInform Abstract: Synthesis of Some Biologically Important Fluorinated 3‐Chlorochromones and 1,5‐Benzothiazepines as Antimicrobial and Antifungal Agents.
Authors: Ghotekar D. S. , Joshi R. S. , Mandhane P. G. , Bhagat S. S. , Gill C. H. 
Published: December 2010

AbstractAll newly synthesized compounds are screened for their antimicrobial activity.
ChemInform Abstract: Design, Synthesis and Qualitative Structure—Activity Evaluations of Novel Hexahydropyrano[3,2‐c][1,2]diazepin‐3(4H)‐one and Tetrahydropyrano[3,2‐b]pyrrol‐2(1H)‐one Derivatives as Anticancer Agents.
Authors: Al‐Tel Taleb H. 
Published: December 2010

AbstractThe synthesis of novel pyrano[3,2‐c]diazepine (III) and pyrano[3,2‐b]pyrrole derivatives (VI) and the cell growth inhibition assay (five human cancer cell lines) for these substances are described.
ChemInform Abstract: Efficient Ring Opening of Epoxides with Trimethylsilyl Azide and Cyanide Catalyzed by Erbium(III) Triflate.
Authors: Procopio Antonio , Costanzo Paola , Dalpozzo Renato , Maiuolo Loredana , Nardi Monica , Oliverio Manuela 
Published: December 2010

AbstractThe transformation proceeds under neutral conditions.
ChemInform Abstract: Rhodium‐Catalyzed Isomerization of Allylic Alcohols in Water at Ambient Temperature.
Authors: Ahlsten Nanna , Lundberg Helena , Martin‐Matute Belen 
Published: December 2010

AbstractThe environmentally benign redox isomerization of secondary and some primary alcohols into carbonyl compounds is catalyzed by the cationic complex [Rh(cod)(MeCN)2]BF4 in combination with phosphatriazaadamantane.
ChemInform Abstract: Copper‐Promoted and Copper‐Catalyzed Intermolecular Alkene Diamination.
Authors: Sequeira Fatima C. , Turnpenny Benjamin W. , Chemler Sherry R. 
Published: December 2010

AbstractThe present new copper(II)‐promoted intra‐ and intermolecular olefin diamination reaction tolerates a wide range of functionalized amines to form various nitrogen heterocycles.
ChemInform Abstract: Stereospecific Decarboxylative Allylation of Sulfones.
Authors: Weaver Jimmie D. , Ka Being J. , Morris David K. , Thompson Ward , Tunge Jon A. 
Published: December 2010

AbstractPd‐catalyzed decarboxylative allylation of sulfonylacetic esters proceeds stereospecifically to give tertiary homoallylic sulfones (II), (IV) in excellent yields and with almost complete retention of enantioselectivities.
ChemInform Abstract: Azidomethyl 4‐Nitrophenyl Carbonate — A Reagent for the One‐Step Introduction of the Azidomethyloxycarbonyl (Azoc) Protecting Group.
Authors: Kaiser Andreas , Richert Clemens 
Published: December 2010

AbstractThe method is successful for reactive aliphatic amines, whereas it fails for aniline or benzyl alcohol under similar conditions.
ChemInform Abstract: Enhanced Reactivity of Silver‐ and Gold‐Catalyzed Hydrogenations Using Silver(I) Salts.
Authors: Crook Robert , Deering John , Fussell Steven J. , Happe Alan M. , Mulvihill Sean 
Published: December 2010

AbstractSilver and gold on aluminum oxide is efficiently activated by AgOAc or Ag2CO3 to produce halogenated anilines selectively.
ChemInform Abstract: Enantioselective Organocatalytic Transfer Hydrogenation of α‐Imino Esters by Utilization of Benzothiazoline as Highly Efficient Reducing Agent.
Authors: Zhu Chen , Akiyama Takahiko 
Published: December 2010

Abstractα‐Amino esters are prepared with excellent enantioselectivities using optically active phosphoric acid BPA as catalyst and benzothiazolines (I).
ChemInform Abstract: C—H Bond Functionalization in Water Catalyzed by Carboxylato Ruthenium(II) Systems.
Authors: Arockiam Percia B. , Fischmeister Cedric , Bruneau Christian , Dixneuf Pierre H. 
Published: December 2010

AbstractA new catalyst system in situ generated from [Ru2Cl4(p‐cymene)2] and potassium pivalate efficiently mediates the direct ortho‐arylation of functional arenes with aryl halides in water.
ChemInform Abstract: Magnetically Separable Nanoferrite‐Anchored Glutathione: Aqueous Homocoupling of Arylboronic Acids under Microwave Irradiation.
Authors: Luque Rafael , Baruwati Babita , Varma Rajender S. 
Published: December 2010

AbstractA nanoferrite‐glutathione catalyst is found to promote efficiently the homocoupling of boronic acids (I) under microwave irradiation conditions (12 examples).
ChemInform Abstract: Palladium‐Catalyzed One‐Pot Suzuki Coupling Followed by Arylpalladium Addition to Aldehyde: A Convenient Route to Fluoren‐9‐one Derivatives.
Authors: Paul Sunanda , Samanta Shubhankar , Ray Jayanta K. 
Published: December 2010

AbstractVarious target compounds can be prepared in moderate to good yields under the optimized conditions starting from aromatic 2‐bromoaldehydes and boronic acid (II).
ChemInform Abstract: New Synthesis of Pyrrole‐2‐carboxylic and Pyrrole‐2,5‐dicarboxylic Acid Esters in the Presence of Iron‐Containing Catalysts.
Authors: Khusnutdinov R. I. , Baiguzina A. R. , Mukminov R. R. , Akhmetov I. V. , Gubaidullin I. M. , Spivak S. I. , Dzhemilev U. M. 
Published: December 2010

AbstractA general method for the introduction of a carboxy group into the pyrrole ring is developed using Fe‐catalyzed reactions of pyrrole derivatives with CCl4—alcohol systems.
ChemInform Abstract: Synthesis of 2‐Oxazolines via Boron Esters of N‐(2‐Hydroxyethyl) Amides.
Authors: Ilkgul Baris , Gunes Deniz , Sirkecioglu Okan , Bicak Niyazi 
Published: December 2010

AbstractThe one‐pot three‐step process is based on the thermolysis of boron esters of hydroxyamides.
ChemInform Abstract: Cu—Mn Bimetallic Catalyst for Huisgen [3 + 2]‐Cycloaddition.
Authors: Yousuf Syed Khalid , Mukherjee Debaraj , Singh Baldev , Maity Sudip , Taneja Subhash Chandra 
Published: December 2010

AbstractCu‐Mn spinel oxide is found to be a robust and recyclable catalyst for the azide‐alkyne cycloaddition reaction both in solution phase and solvent‐free microwave irradiation conditions.
ChemInform Abstract: An Effective Synthesis of 5,4′‐Disubstituted Flavones via a Cesium Enolate Assisted Intramolecular ipso‐Substitution Reaction.
Authors: Matsugi Masato , Takeda Masaki , Takahashi Ayano , Tazaki Takahide , Tamura Hiroto , Shioiri Takayuki 
Published: December 2010

AbstractWith a view to obtaining androgen receptor antagonists, the title compounds (III), (VI), and (X) are prepared.
ChemInform Abstract: Design and Synthesis of Fluorine‐Substituted 3‐Hydroxypyridin‐4‐ones.
Authors: Ma Yong Min , Hider Robert C. 
Published: December 2010

AbstractSeveral 2‐ and 5‐fluoro‐containing 3‐hydroxpyridin‐4‐ones such as (I)‐(IV) are prepared as modified analogues of the known drug deferiprone (V) in order to get substances with improved pharmaceutical profile.
ChemInform Abstract: 3‐(Hetarylamino)‐ and 3‐[(Hetarylmethyl)amino]isoquinolin‐1(2H)‐ones.
Authors: Potikha L. M. , Gutsul R. M. , Kovtunenko V. A. , Tolmachev A. A. 
Published: December 2010

AbstractThe reaction of 2‐(cyanomethyl)benzoic acid (I) with hetarylamines (II) leads selectively to 3‐aminoisoquinolinones (III).
ChemInform Abstract: Synthetic Studies of Some Varied Structural Systems of Biologically Potent Polynitrogen Heteropolycyclics.
Authors: Gupta Shallu , Gupta Poonam , Sachar Anand , Sharma Rattan L. 
Published: December 2010

AbstractStarting from barbituric acid and using classical synthetic methods a variety of fused nitrogen heterocycles is synthesized and screened for antimicrobial activity.
ChemInform Abstract: Synthesis and Antimicrobial Activities of Novel 5‐Substituted Pyrimidin‐2,4,6‐triones.
Authors: Goudgaon N. M. , Batil S. B. , Rahaman S. A. , Reddy CH Upendar 
Published: December 2010

AbstractReaction of barbituric acid (I) with aromatic or heteroaromatic aldehydes gives the corresponding chalcones, which on reduction with NaBH4 yield the desired novel 5‐(het)arylmethylpyrimidinetriones (IV) and (VII).
ChemInform Abstract: Synthesis of New Series of Quinoxaline Based MAO‐Inhibitors and Docking Studies.
Authors: Khattab Sherine N. , Hassan Seham Y. , Bekhit Adnan A. , El Massry Abdel Moneim , Langer Vratislav , Amer Adel 
Published: December 2010

AbstractSynthesized compounds are investigated for their monoamine oxidase (MAO) inhibitory activity.