bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the benefits and safety profile of incorporating poly ADP-ribose polymerase (PARP) inhibitors in the treatment of advanced lung cancer: a thorough systematic review and meta-analysis
Authors: Tang Min , Wang Yue , Li Pulin , Han Rui , Wang Ran 
Published: June 2024

BackgroundPoly (ADP-Ribose) Polymerase (PARP) inhibitors represent a novel class of drugs that hinder DNA repair mechanisms in tumor cells, leading to cell death. This systematic review aims to evaluate the effectiveness, safety, and potential adverse effects of PARP inhibitors (PARPi) in the management of patients with advanced lung cancer.Materials and MethodsWe conducted a comprehensive search for relevant studies in PubMed, Embase, Cochrane, and ClinicalTrials.gov. We extracted primary and secondary outcome measures, including progression-free survival (PFS), overall survival (OS), and adverse events (AEs), from the identified literature for subsequent meta-analysis and systematic review.ResultsThis study encompassed twelve randomized controlled trials, involving 3,132 patients with advanced lung cancer. In comparison to non-PARPi treatments, the administration of PARPi significantly extended OS (hazard ratio (HR) = 0.90, 95% CI = 0.83–0.97, p = 0.006). However, the difference in PFS did not reach statistical significance.ConclusionIn summary, therapies incorporating PARPi provide a degree of benefit by extending OS in patients with advanced lung cancer. Nonetheless, further trials are necessary to furnish additional evidence regarding the efficacy and safety of PARPi in the treatment of lung cancer.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/, identifier number: CRD42023424673.
Evidence of synergistic mechanisms of hepatoprotective botanical herbal preparation of Pueraria montana var. lobata and Schisandra sphenanthera
Authors: Lv Yang , Li Huan , Zhai Bing-Tao , Sun Jing , Cheng Jiang-Xue , Zhang Xiao-Fei , Guo Dong-Yan 
Published: June 2024

BackgroundPueraria montana var. lobata (Willd.) Maesen &amp; S.M.Almeida ex Sanjappa &amp; Predeep (syn. Pueraria lobata (Willd.) Ohwi) and Schisandra sphenanthera Rehder &amp; E.H. Wilson are traditional edible and medicinal hepatoprotective botanical drugs. Studies have shown that the combination of two botanical drugs enhanced the effects of treating acute liver injury (ALI), but the synergistic effect and its action mechanisms remain unclear. This study aimed to investigate the synergistic effect and its mechanism of the combination of Pueraria montana var. lobata (Willd.) Maesen &amp; S.M.Almeida ex Sanjappa &amp; Predeep (syn. Pueraria lobata (Willd.) Ohwi) (PM) and Schisandra sphenanthera Rehder &amp; E.H. Wilson (SS) in the treatment of ALI.MethodsHigh performance liquid chromatography (HPLC) were utilized to conduct the chemical interaction analysis. Then the synergistic effects of botanical hybrid preparation of PM-SS (BHP PM-SS) against ALI were comprehensively evaluated by the CCl4 induced ALI mice model. Afterwards, symptom-oriented network pharmacology, transcriptomics and metabolomics were applied to reveal the underlying mechanism of action. Finally, the key target genes were experimentally by RT-qPCR.ResultsChemical analysis and pharmacodynamic experiments revealed that BHP PM-SS was superior to the single botanical drug, especially at 2:3 ratio, with a better dissolution rate of active ingredients and synergistic anti-ALI effect. Integrated symptom-oriented network pharmacology combined with transcriptomics and metabolomics analyses showed that the active ingredients of BHP PM-SS could regulate Glutathione metabolism, Pyrimidine metabolism, Arginine biosynthesis and Amino acid sugar and nucleotide sugar metabolism, by acting on the targets of AKT1, TNF, EGFR, JUN, HSP90AA1 and STAT3, which could be responsible for the PI3K-AKT signaling pathway, MAPK signaling pathway and Pathway in cancer to against ALI.ConclusionOur study has provided compelling evidence for the synergistic effect and its mechanism of the combination of BHP PM-SS, and has contributed to the development and utilization of BHP PM-SS dietary supplements.
A defect detection method for industrial aluminum sheet surface based on improved YOLOv8 algorithm
Authors: Wang Luyang , Zhang Gongxue , Wang Weijun , Chen Jinyuan , Jiang Xuyao , Yuan Hai , Huang Zucheng 
Published: June 2024

In industrial aluminum sheet surface defect detection, false detection, missed detection, and low efficiency are prevalent challenges. Therefore, this paper introduces an improved YOLOv8 algorithm to address these issues. Specifically, the C2f-DSConv module incorporated enhances the network’s feature extraction capabilities, and a small target detection layer (160 × 160) improves the recognition of small targets. Besides, the DyHead dynamic detection head augments target representation, and MPDIoU replaces the regression loss function to refine detection accuracy. The improved algorithm is named YOLOv8n-DSDM, with experimental evaluations on an industrial aluminum sheet surface defect dataset demonstrating its effectiveness. YOLOv8n-DSDM achieves an average mean average precision (mAP50%) of 94.7%, demonstrating a 3.5% improvement over the original YOLOv8n. With a single-frame detection time of 2.5 ms and a parameter count of 3.77 M, YOLOv8n-DSDM meets the real-time detection requirements for industrial applications.
Are different generations of female employees trapped by work-family conflicts? A study on the impact of family-supportive supervisor behavior on thriving at work
Authors: Zhao Xiao , Zhang Tian , Choi Myeongcheol , Xu Jingyi 
Published: June 2024

IntroductionWith women's advancement in education and status, they drive corporate and social progress. However, traditional gender roles burden female employees with more family responsibilities, challenging work-life balance and affecting job performance. Organizations should supporting female employees to address these challenges. Thriving at work, a core aspect of positive work engagement, helps maintain enthusiasm and efficiency. This study explores the impact of family-supportive supervisor behavior (FSSB) on the thriving at work of female employees in China, considering generational differences in their work-family balance needs and the mediating mechanisms involved.MethodsThe methodology adopted in this study utilized Amos 26.0 and SPSS 25.0 to analyze data obtained from a sample of 279 female employees in China. Specifically, the study examined the direct impact of FSSB on thriving at work, alongside the mediating influence of work-family balance. Moreover, the research aimed to discern variations in these effects across different generational cohorts.ResultsThis study highlights the direct impact of FSSB on female employees' thriving at work across different generational cohorts. Notably, the “post-90s” generation displayed the strongest direct effect of FSSB on thriving at work. Additionally, the impact of FSSB on work-family balance varied by generation, with the “post-90s” generation showing the weakest effect. Furthermore, the mediating role of work-family balance differed among generations, with complete mediation observed in the “post-80s” generation but no mediating effect in the “post-90s” generation, reflecting their distinct work-life balance priorities and needs.DiscussionThis study uses a generational difference perspective to explore the main and mediating effects of FSSB on thriving at work, enriching the theoretical research on generational differences and providing valuable insights for future research. Practically, organizations should focus on the needs of different generations while encouraging FSSB, fostering a supportive work environment and enhancing outcomes.
The indirect effects of perfectionism on athletes’ self-views through maladaptive emotion regulation
Authors: Minichiello Hollie , Reasonover Madisen , Fuglestad Paul 
Published: June 2024

IntroductionIn general, increased levels of perfectionism have been associated with increased levels of burnout, heightened levels of depression and anxiety, lowered self-esteem, and poorer overall performance, yet perfectionistic strivings within athletes have also been associated with lower burnout and better performance in some contexts.MethodsThe current study investigated whether emotion regulation strategies would indirectly link perfectionism with self-esteem in young adults who had participated in competitive athletics. Two hundred and fifty-three primarily white (60.0 %), female (83.0 %) undergraduate students who had participated in competitive athletics completed a series of questionnaires including: the Self-liking and Self-Competence Scale – Revised, the Cognitive Emotion Regulation Questionnaire, and the short form of the Multidimensional Perfectionism Scale.ResultsThe PROCESS macro for SPSS was used to examine the indirect association between perfectionism and self-esteem through emotion regulation. Higher self-oriented perfectionism and socially prescribed perfectionism were both indirectly associated with lower self-liking and self-competence through greater catastrophizing and self-blame.DiscussionFor individuals like athletes, who experience internal and external pressures, increased perfectionism may lead to negative self-views through maladaptive emotion regulation. However, longitudinal and experimental work is needed to establish this proposed pattern of relationships.
Identifying vulnerable mother-infant dyads: a psychometric evaluation of two observational coding systems using varying interaction periods
Authors: Sharp Helen , Vitoratou Silia , O’Mahen Heather , Bozicevic Laura , Refberg Miriam , Hayes Chloe , Gay Jessica , Pickles Andrew 
Published: June 2024

IntroductionClinical services require feasible assessments of parent-infant interaction in order to identify dyads requiring parenting intervention. We assessed the reliability and predictive validity of two observational tools and tested whether briefer forms could be identified which retain acceptable psychometric properties over short observation periods.MethodsA stratified high-risk community sample of 250 mother-infant dyads from The Wirral Child Health and Development Study completed 7-min play-based interaction at 6–8 months. Film-footage was independently coded by two trained raters using PIIOS and NICHD-SECCYD systems. Incremental predictive validity was assessed from 3, 5 and 7 min observation to attachment outcomes (Strange Situation; 14 months) and infant mental health (BITSEA; 14 and 30 months).ResultsExcellent inter-rater reliability was evident at code and subscale level for each tool and observation period. Stability of within-rater agreement was optimal after 5 min observation. ROC analysis confirmed predictive (discriminant) validity (AUCs &gt;0.70) to top decile age 2 mental health outcomes for PIIOS total score and a brief 3-item composite from NICHD-SECCYD (sensitivity, intrusiveness, positive regard; NICHD-3), but not to attachment outcomes. Logistic regression showed dyads rated at-risk for externalizing problems using NICHD-3 were also at significantly higher risk for insecurity at 14 months (OR = 2.7, p = 0.004).ConclusionPIIOS total and NICHD-3 ratings from 5 min observation are both reliable and valid tools for use in clinical practice. Findings suggest NICHD-3 may have greater utility due to its comparative brevity to train and code, with suitability for use over a broader developmental time frame (3–24 months).
Overvaluation of weight and shape in obesity: a comparative study between people with and without binge eating disorder
Authors: Escandón-Nagel Neli , Peró-Cebollero Maribel , Grau Antoni , Soriano José , Feixas Guillem 
Published: June 2024

IntroductionThe overvaluation of weight and shape is a diagnostic criterion in eating disorders, except in binge eating disorder (BED), where it has received less attention. This aspect is also not usually analyzed in people with overweight or obesity without an eating disorder. This research aims to identify the indicators of symptomatology, as well as those of self-construction and cognitive structure, that are associated with overvaluation in obesity, either alone or in conjunction with BED.MethodA sample of 102 overweight or obese participants was accessed. The sample was divided into four groups: one without overvaluation or BED (n = 33); a second with overvaluation and without BED (n = 21); a third with BED, but without overvaluation (n = 15), and a fourth with BED and overvaluation (n = 33). The groups completed instruments regarding eating symptomatology, anxiety, depression, and stress. In addition, they were administered the Repertory Grid Technique, a semi-structured interview to evaluate the cognitive structure involved in the construal of the self and others.ResultsThe factors of overvaluation and the presence of BED independently explained eating symptomatology, and the latter also showed a tendency to influence anxiety, depression, and stress. In terms of cognitive structure, weight polarization was explained by overvaluation, while BED was associated with a high presence of cognitive conflicts. In self-construction, BED was the factor that explained the differences, particularly in Self-Ideal discrepancy.DiscussionThe results highlight the importance of overvaluation in obesity, even in the absence of BED. Its evaluation and treatment are recommended. Furthermore, in the case of BED, it is also advisable to evaluate the overvaluation of weight and shape since it can be a severity specifier.
Race and ethnicity moderate the associations between lifetime psilocybin use and past year hypertension
Authors: Jones Grant M. , Ricard Jocelyn A. , Nock Matthew K. 
Published: June 2024

BackgroundHypertension is a major source of morbidity and mortality worldwide, particularly for racial and ethnic minorities who face higher rates of hypertension and worse health-related outcomes. Recent research has reported on protective associations between classic psychedelics and hypertension; however, there is a need to explore how race and ethnicity may moderate such associations.MethodsWe used data from the National Survey on Drug Use and Health (2005–2014) to assess whether race and ethnicity moderate the associations between classic psychedelic use – specifically psilocybin – and past year hypertension.ResultsHispanic identity moderated the associations between psilocybin use and past year hypertension. Furthermore, individuals who used psilocybin and identified as Non-Hispanic White had reduced odds of hypertension (aOR: 0.83); however, these associations were not observed for any other racial or ethnic groups in our study for individuals who used psilocybin.ConclusionOverall, our results demonstrate that the associations between psychedelics and hypertension may vary by race and ethnicity. Longitudinal studies and clinical trials can further advance this research and determine whether such differences exist in causal contexts.Project registrationhttps://osf.io/xsz2p/?view_only=0bf7b56749034c18abb2a3f8d3d4bc0b.
Omega-3 PUFAs’ efficacy in the therapy of coronary artery disease combined with anxiety or depression: a meta-analysis
Authors: Gui Yiwei , He Dongyu , Li Junwei , Zhao Haibin 
Published: June 2024

ObjectiveThe evidence demonstrates that omega-3 polyunsaturated fatty acids (omega-3 PUFAs) protect the cardiovascular system and alleviate anxious or depressive situations. We conducted a meta-analysis to evaluate the effectiveness of omega-3 PUFAs in the treatment of anxiety or depressive states in patients with coronary artery disease.MethodsThis meta-analysis analyzed data from randomized controlled trials to determine the efficacy of omega-3 PUFAs alone or in combination with conventional psychotropic medications in coronary artery disease patients suffering from anxiety or depression. Primary outcomes included changes in depression scores, the Beck Anxiety Inventory (BAI) scores, and the omega-3 index.ResultsIncluded were 6 trials involving 2,570 participants. Compared to controls,omega-3 PUFAs did not improve depression or anxiety {depression: [SMD=0.09 (95% CI: -0.07, 0.26)], anxiety [BAI: SMD=0.07 (95% CI: -0.17, 0.32)]}; For the results of the subgroup analyses, analyzed by different types of depression scales, four studies used the HAMD scale [SMD=0.19 (95% CI: -0.20, 0.58)]; 5 studies used the BDI-II scale [SMD=0.01 (95% CI: -0.07, 0.09)], all of which indicated no decrease in depression scale scores; analyzed by different types of intervention, 3 studies used the omega-3 PUFAs group [SMD=0.24 (95% CI: -0.26, 0.74)]; 2 studies used sertraline + omega-3 PUFAs [SMD=-0.08 (95% CI: -0.46, 0.31)], and the omega-3 index was elevated [SMD=1.33 (95% CI: 0.18, 2.49)], suggesting that the body’s omega-3 content was indeed replenished but did not change the patient’s depressive state; analyzed by different courses of therapy, a 10-week course of therapy [SMD=0.02 (95% CI: -0.23, 0.26)] and a 12-week course of therapy [SMD=0.40 (95% CI: -0.40, 1.20)] both resulted in a lack of improvement in depressive symptoms.ConclusionAccording to the available evidence, omega-3 PUFAs do not alleviate anxiety or depression in coronary artery disease patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023391259.
Childhood trauma, psychache, and depression among university students: a moderated mediation model
Authors: Chen Shufeng , Fu Tiantian , Wang Yiwen , Sun Guoxiao 
Published: June 2024

BackgroundChildhood trauma is a potential threat to depression and can have a lifelong impact on the mental health of university students. Our study aimed to construct a moderated mediation model to explore the relationship between childhood trauma, psychache, ambivalence over emotional expression, physical activity, and depression in university students.MethodsA cross-sectional study was conducted in three universities in China, recruiting 476 university students using self-report questionnaires. The moderated mediation model was examined using the SPSS PROCESS model 21.ResultsAmbivalence over emotional expression (F=12.843), childhood trauma (F=117.639), and psychache (F=581.594) all had a significant positive effect on depression (p&lt;0.001), explaining 2.9%, 21.7%, and 56.8% of the variance, respectively. On the chain of influence between childhood trauma and depression, the mediating effect of psychache, the moderating effect of ambivalence over emotional expression, and the moderating effect of physical activity are all significant the overall indirect effect value of the three is 0.287, accounting for 61.59% of the total effect.ConclusionThis study investigated the relationship between childhood trauma, ambivalence over emotional expression, psychache, physical activity, and depression in university students. Future interventions should focus on developing good emotional expression among university students, increasing opportunities for physical activity, and reducing psychache to reduce depression.
Influence of non-pharmaceutical interventions during the COVID-19 pandemic on respiratory viral infections – a prospective population-based cohort study
Authors: Käding Nadja , Waldeck Frederike , Meier Bjarne , Boutin Sébastien , Borsche Max , Balck Alexander , Föh Bandik , Kramer Jan , Klein Christine , Katalinic Alexander , Rupp Jan 
Published: June 2024

Non-pharmaceutical interventions (NPI) have been proven successful in a population-based approach to protect from SARS-CoV-2 transmission during the COVID-19 pandemic. As a consequential-effect, a reduction in the spread of all respiratory viruses has been observed, but the primary factors behind this phenomenon have yet to be identified. We conducted a subgroup analysis of participants from the ELISA study, a prospective longitudinal cohort study on SARS-CoV-2 transmission, at four timepoints from November 2020 – September 2022. The aim was to provide a detailed overview of the circulation of respiratory viruses over 2 years and to identify potential personal risk factors of virus distribution. All participants were screened using qPCR for respiratory viral infections from nasopharyngeal swabs and answered a questionnaire regarding behavioral factors. Several categories of risk factors for the transmission of respiratory viruses were evaluated using a scoring system. In total, 1,124 participants were included in the study, showing high adherence to governmental-introduced NPI. The overall number of respiratory virus infections was low (0–4.9% of participants), with adenovirus (1.7%), rhino−/enterovirus (3.2%) and SARS-CoV-2 (1.2%) being the most abundant. We detected an inverse correlation between the number and intensity of NPI and the number of detected respiratory viruses. More precisely, the attendance of social events and household size was associated with rhino−/enterovirus infection while social contacts were associated with being positive for any virus. NPI introduced during the COVID-19 pandemic reduced the occurrence of seasonal respiratory viruses in our study, showing different risk-factors for enhanced transmission between viruses.Trial registrationDRKS.de, German Clinical Trials Register (DRKS), Identifier: DRKS00023418, Registered on 28 October 2020.
The influence of recall direction on judgments of subjective temporal distance from the beginning of the COVID-19 pandemic lockdowns
Authors: Dantzler Connor , Markman Keith D. 
Published: June 2024

IntroductionIn a series of 5 studies, Lam and Buehler found that first-year university students felt closer to a target event (the day they learned that they were accepted into university) when they recalled a stream of related events in a backward direction (a reverse-chronological order ending with the target event) than when they recalled those events in a forward direction (a forward-chronological order beginning with the target event).MethodsIn a conceptual replication of their Study 2, we asked participants how close they felt to the first day that lockdowns were imposed in response to the Covid-19 pandemic in the U.S. (federally mandated on March 13, 2020) following either backward or forward recall of a stream of related events.ResultsThe results of the present study ran directly counter to those of Lam and Buehler: participants rated the first day of lockdowns as feeling closer following forward recall than following backward recall.DiscussionPotential explanations for this reversal of Lam and Buehler's effect are discussed that focus on the temporal distortions that people have been found to experience when they think about autobiographical events that occurred at the beginning of the pandemic.