bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-effectiveness analysis of sequential two-step screening versus direct colonoscopy screening for colorectal cancer: a large-scale survey in Eastern China
Authors: Fu Yun , Li Hao , Xu Ao , Yang Zhongrong , Zhang Peng , Wang Weibing 
Published: February 2025

ObjectivesDespite the implementation of colorectal cancer (CRC) screening programs in many regions worldwide over the past few decades, the cost-effectiveness of these programs has been questioned owing to their acceptance rates. In this study, we evaluated the cost-effectiveness of screening strategies, quantified the impact of colonoscopy acceptance rates, and analyzed the underlying factors driving individual preferences.MethodsThe cost-effectiveness of three strategies—no screening, sequential two-step screening (fecal immunochemical test and risk assessment, followed by colonoscopy), and colonoscopy screening—was evaluated from a societal perspective. This assessment was conducted using a decision-tree Markov model with the incremental cost-effectiveness ratio as the primary evaluation criterion.ResultsSequential screening was more cost-effective than colonoscopy screening (19,335 vs. 27,379 United States dollars per quality-adjusted life year). Ideal sequential screening could prevent 32.2%(691/2147) CRC deaths, whereas colonoscopy screening at the same colonoscopy acceptance rate (20.3%) could prevent 17.6%(377/2147) CRC deaths. When the acceptance rate of direct colonoscopy surpasses the threshold of 37.2%, the resulting health benefits likely outweigh those achieved using a the sequential two-step screening approach.ConclusionsSequential screening is recommended for individuals in areas with constrained screening resources or during the early stages of regional screening program implementation. However, once screening habits are established, transitioning to direct colonoscopy screening becomes more favorable. Notably, reducing colonoscopy costs is the principal factor for enhancing an individual’s willingness to undergo the procedure.
Competency self-assessment for a learning-based autonomous aircraft system
Authors: Conlon Nicholas , Acharya Aastha , McGinley Jamison , Slack Trevor , Hirst Camron A. , D’Alonzo Marissa , Hebert Mitchell R. , Reale Christopher , Frew Eric W. , Russell Rebecca , Ahmed Nisar R. 
Published: February 2025

IntroductionFuture concepts for airborne autonomy point toward human operators moving out of the cockpit and into supervisory roles. Urban air mobility, airborne package delivery, and military intelligence, surveillance, and reconnaissance (ISR) are all actively exploring such concepts or currently undergoing this transition. Supervisors of these systems will be faced with many challenges, including platforms that operate outside of visual range and the need to decipher complex sensor or telemetry data in order to make informed and safe decisions with respect to the platforms and their mission. A central challenge to this new paradigm of non-co-located mission supervision is developing systems which have explainable and trustworthy autonomy and internal decision-making processes.MethodsCompetency self-assessments are methods that use introspection to quantify and communicate important information pertaining to autonomous system capabilities and limitations to human supervisors. We first discuss a computational framework for competency self-assessment: factorized machine self-confidence (FaMSeC). Within this framework, we then define the generalized outcome assessment (GOA) factor, which quantifies an autonomous system’s ability to meet or exceed user-specified mission outcomes. As a relevant example, we develop a competency-aware learning-based autonomous uncrewed aircraft system (UAS) and evaluate it within a multi-target ISR mission.ResultsWe present an analysis of the computational cost and performance of GOA-based competency reporting. Our results show that our competency self-assessment method can capture changes in the ability of the UAS to achieve mission critical outcomes, and we discuss how this information can be easily communicated to human partners to inform decision-making.DiscussionWe argue that competency self-assessment can enable AI/ML transparency and provide assurances that calibrate human operators with their autonomous teammate’s ability to meet mission goals. This in turn can lead to informed decision-making, appropriate trust in autonomy, and overall improvements to mission performance.
COL7A1 indicates crucial potential as a basal membrane-related prognostic biomarker and therapeutic target in lung adenocarcinoma
Authors: Zhang Jiao , Zi Rui , Hu Ping , Jiang Zongying , Lv Ye , Zhang Haixia , Zhao Yanjiao , Wang Yan , Zhao Lujun 
Published: February 2025

IntroductionLung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer. Basal membrane (BM) is important to the invasive processes of LUAD. Our object is to explore hub BM-related genes in LUAD.MethodsThe gene expression data of LUAD were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus databases. The weighted gene co-expression network analysis and differentially expressed gene analysis were used to identify candidates. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were used to evaluate their functions. Univariate Cox regression analysis was used to evaluate the prognostic value, and multivariate Cox regression analysis was used to verify its independence as a prognostic risk factor. The qPCR and Western blot were performed to ascertain the hub gene expression. The survival curve of two groups was drawn using Kaplan-Meier method. The hub gene-related immune characteristics were analyzed in independent cohorts by ESTIMATE and CIBERSORT methods.ResultsWe successfully identified COL7A1 as a BM-related prognostic biomarker in LUAD, with elevated expression compared to controls, and associated with poor prognosis. Functional enrichment analysis revealed it was involved in pathways related to cell proliferation and inflammation like ECM-receptor interaction. Time-dependent ROC analysis results showed that the AUC of COL7A1 in predicting 1-, 3-, and 5-year survival all exceeded 0.78. Immune infiltration characteristic analysis showed that the higher COL7A1 expression group exhibited lower ESTIMATE scores and higher TIDE scores.DiscussionOur study identified COL7A1 as a reliable BM-related prognostic biomarker, providing a new reference for the mechanistic understanding and target therapy of LUAD.
Reciprocal longitudinal effects between sense of school belonging and academic achievement: quasi-experimental estimates using United States primary school data
Authors: Sakellariou Chris 
Published: February 2025

IntroductionThis study investigates the bidirectional relationship between earlier sense of school belonging and later academic achievement in schoolchildren at grades 4 and 5 in US schools, using ECLS-K:2011 longitudinal data.MethodsTwo alternative estimation methods were used, both addressing biases due to endogenous covariates.Results and discussionThe findings (sample size &gt; 8,000 observations) provide strong evidence that (1) the dominant effect is from sense of school belonging to achievement, where lower bound effect sizes are substantially larger than those reported in correlational studies; and (2) in the opposite direction biases are small, and bias-corrected effect estimates are generally in line with the multiple regression estimates. The findings also provide suggestive evidence of larger effects for girls compared to boys in the direction from sense of school belonging to achievement scores. The study’s findings provide useful insights into the potential impact of school-based interventions.
Wind energy development in Norway: exploring the emotional landscape
Authors: Lundheim Sigurd Hilmo , Löfström Erica 
Published: February 2025

IntroductionIn Norway, despite ambitious goals for a low-carbon society, the extensive extraction of fossil fuels persists, accompanied by widespread climate skepticism. Wind energy is proposed as a solution but faces resistance.MethodsThis study examines the experiences of both developers and opponents of wind energy through qualitative interviews. Using appraisal theory, we classify emotional reactions, finding sadness and disgust as the most prominent negative emotions.Results and discussionAdditionally, fear and frustration were prevalent, reflecting tensions between wind energy and individual values. Emotional reactions vary widely and suggest that opposition to wind energy is multifaceted. Opponents exhibit stronger emotional responses, while developers, representing business interests, show less intense emotions. We identified 23 key triggers for these emotions, which often can be seen as disruptions caused by the development of wind energy. Engagement, comprising cognitive, affective, and behavioral elements, is essential to addressing these conflicts. Early engagement gives stakeholders the opportunity to influence the process, thereby reducing the conflict level. This highlights the need for earlier and more inclusive engagement processes to foster meaningful dialog and uphold democratic principles.
The quest for systematization in educational psychology practice—the case of SDQ
Authors: Szulevicz Thomas , Arnfred Jon Busck 
Published: February 2025

IntroductionThe field of Educational Psychology (EP) practice is currently shaped by debates on the balance between systematized and situated approaches. This study explores these debates through the lens of the Strengths and Difficulties Questionnaire (SDQ).MethodsUtilizing data from a current research project, the application of the SDQ in EP practice was analyzed. The study involved analyses of SDQ responses and psychoeducational reports and interviews with educational psychologists who used the SDQ in their assessments.ResultsThe findings indicate that the participating educational psychologists were generally satisfied with the use of the SDQ. Additionally, a significant portion of the SDQ responses suggested that many of the examined children exhibited symptoms warranting further investigation for ADHD.DiscussionThe article concludes with a discussion on the dual perspectives regarding the systematic use of the SDQ. On one hand, there are arguments for its systematic application On the other hand, while a standardized use of the SDQ ensures systematic information, the questionnaire also contributes to a specific framing of the issue. It is crucial to recognize that the SDQ, originally developed by a child psychiatrist and not specifically designed for EP practice, frames the understanding of issues in a predominantly psychiatric manner. This can lead to a narrow focus on diagnosing and treating perceived deficiencies, potentially overlooking the broader educational and contextual factors that influence student wellbeing.
The impact of depression and anxiety on the correlation between somatic symptom disorder and subjective cognitive decline in the Chinese elderly population: an exploration by simple, serial, and moderated mediation models
Authors: Lin Yongsen , Lin Pingzhen , Zeng Guiying , Wu Shufang , Chen Ronghua , Xiao Yingchun , Chen Hongbin 
Published: February 2025

BackgroundSomatic symptom disorder (SSD) exacerbates subjective cognitive decline (SCD). This association can be significantly impacted by the mental well-being of the SSD patients. However, the underlying mechanisms remain obscure.MethodsA total of 525 elderly patients, who visited the Department of Neurology of Fujian Medical University Union Hospital between October 2017 and August 2024, and the Department of Neurology of Quanzhou First Hospital Affiliated to Fujian Medical University between August 2022 and August 2024, were included in the study. Data of sociodemographics, medical history, somatic symptom disorder, subjective cognitive decline, depression, and anxiety were analyzed by simple, serial and moderated mediation models to evaluate the impact of depression and anxiety on the linkage between SSD and SCD.ResultsSSD significantly affected SCD. Simple mediation analysis showed that depression and anxiety significantly mediated the association between SSD and SCD (βdepression = 0.079, 95% CI: 0.030 to 0.132; βanxiety = 0.058, 95% CI: 0.031 to 0.093). Serial mediation analyses indicated that the worsening of SSD exacerbates anxiety, in turn aggravating depressive symptoms and SCD (βb = 0.044, 95% CI: 0.026 to 0.069). Moderated mediation model revealed that the depressive symptoms-conferred mediation of the correlation between SSD and SCD was moderated by anxiety symptoms (β = −0.073, 95% CI: −0.131 to −0.014).ConclusionThese findings provided new insights into possible avenues for prevention and intervention of SCD through SSD-based treatments with a multifaceted approach to psychiatric disorders.
Symptoms of common mental disorders and suicidality among female survivors of war related sexual and gender based violence in one stop centers of the Amhara region, Ethiopia: a multicenter cross-sectional study
Authors: Michael Tsion , Demeke Solomon Moges 
Published: February 2025

IntroductionCommon mental disorders (CMDs) and suicidality are two of the most common psychological and mental health issues associated with acute and chronic sexual and gender-based violence (SGBV). Thus, the purpose of this study was to determine the magnitude of symptoms of CMDs, and suicidality among females experienced SGBV in Ethiopia.MethodA cross-sectional study was conducted among 407 female survivors of SGBV in the One Stop Centers of the Amhara region. Data analysis was performed using SPSS version 25. The odds ratio at a p-value of 0.05 was used to determine the strength of the association of the independent variables with CMDs and suicidality.ResultsA total of 407 women participated in the study. Suicidality was reported by a quarter of the survivors (24.1%), while CMDs were reported by nearly two-thirds (61.7%). Being widowed (AOR = 3.0, 95% CI = 3.0 [1.22, 7.66]), having a family history of mental illnesses (AOR = 7.1, 95% CI = 7.1 [4.07, 12.39)], being low-income (AOR = 2.8, 95% CI = 2.8 [1.64, 5.06]), and current drug use (AOR = 2.9, 95% CI = 2.9 [1.63, 5.16]) were all linked with CMDs. Having a history of abortion (AOR = 4.1, 95% CI = 4.1 [1.9, 8.5]), CMDs (AOR = 4.6, 95% CI = 4.6 [2.0, 10.74]), and history of suicide (AOR = 3.41, 95% CI = 3.41 [1.22, 9.55]) were some of the characteristics that were substantially linked with suicidality.ConclusionFemales with SGBV had a high prevalence of CMDs and suicidality and calls for comprehensive remedies.
Frequency-dependent changes in the amplitude of low-frequency fluctuations in post stroke apathy: a resting-state fMRI study
Authors: Liu Ying , Hsien Yi-Kuang , Su Wenlong , Tang Zhiqing , Li Hui , Long Junzi , Liao Xingxing , Zhang Hao 
Published: February 2025

BackgroundApathy is a prevalent psychiatric condition after stroke, affecting approximately 30% of stroke survivors. It is associated with slower recovery and an increased risk of depression. Understanding the pathophysiological mechanisms of post stroke apathy (PSA) is crucial for developing targeted rehabilitation strategies.MethodsIn this study, we recruited a total of 18 PSA patients, 18 post-stroke non-apathy (NPSA) patients, and 18 healthy controls (HCs). Apathy was measured using the Apathy Evaluation Scale (AES). Resting-state functional magnetic resonance imaging (rs-fMRI) was utilized to investigate spontaneous brain activity. We estimated the amplitude of low-frequency fluctuation (ALFF) across three different frequency bands (typical band: 0.01–0.08 Hz; slow-4: 0.027–0.073 Hz; slow-5: 0.01–0.027 Hz) and the fractional amplitude of low-frequency fluctuation (fALFF).ResultsBand-specific ALFF differences among the three groups were analyzed. Significant differences were found in the typical band within the left lingual gyrus, right fusiform gyrus, right superior temporal gyrus (STG), and left insula. In the slow-4 band, significant differences were observed in the left middle frontal gyrus (MFG) and right STG. In the slow-5 band, significant differences were identified in the left calcarine cortex and right insula. For fALFF values, significant differences were found in the left lingual gyrus and right thalamus. Moreover, positive correlations were observed between AES scores and the ALFF values in the right STG (r = 0.490, p = 0.002) in the typical band, left MFG (r = 0.478, p = 0.003) and right STG (r = 0.451, p = 0.006) in the slow-4 band, and fALFF values of the right thalamus (r = 0.614, p &lt; 0.001).ConclusionThis study is the first to investigate the neural correlates of PSA using voxel-level analysis and different ALFF banding methods. Our findings indicate that PSA involves cortical and subcortical areas, including the left MFG, right STG, and right thalamus. These results may help elucidate the neural mechanisms underlying PSA and could serve as potential neuroimaging indicators for early diagnosis and intervention.
Influencing factors of depressive symptoms during pregnancy in Beijing, China
Authors: He Xiayue , Wang Xiaoqian , Li Guoguang , Zhu Simin , Wu Yifan , Sun Xiaotong , Wu Yuze , Hu Bo , Wu Jianyin , Feng Lina , Li Guihong , Zhang Lei , Wang Ning , Li Xuehan 
Published: February 2025

ObjectivePrenatal depression is a prevalent mental health challenge encountered during pregnancy and is notably associated with adverse maternal and neonatal outcomes. This study aimed to elucidate the likelihood and determinants of depressive symptoms among pregnant individuals in Beijing, thereby laying a foundational framework for the theoretical underpinning of prenatal screening and preemptive interventions for mental disorders.MethodsThe study dataset was derived from 4,564 pregnant individuals in Beijing utilizing a cross-sectional survey methodology. Data collection focused primarily on the personal and obstetric information of the participants. The Edinburgh Postnatal Depression Scale (EPDS) was employed as the primary screening tool to identify depressive symptoms.ResultsThe prevalence of depressive symptoms among the included pregnant individuals was 4.1%. The univariate analysis results revealed statistically significant differences in the incidence of depressive symptoms in women with different parities, numbers of births, medication use, numbers of abortions, prepregnancy weights, and body mass indices (BMIs) (the χ2 values were 61.130, 52.008, 23.291, 5.293, and 12.681, respectively; P&lt;0.05). There were statistically significant differences in the incidence of depressive symptoms among women with different occupation types (χ2 = 30.263, P&lt;0.01). The multivariate logistic regression analysis results revealed that a greater number of pregnancies, number of births, and BMI were risk factors for prenatal depression, whereas the commercial and service worker occupation types were protective factors against prenatal depression.ConclusionFuture directives should emphasize the enhancement of screening for depressive symptoms among pregnant individuals with greater parity and BMIs, alongside encouraging continued employment and flexible job selection. It is imperative to implement suitable intervention strategies for pregnant individuals exhibiting depressive symptoms to mitigate the incidence of adverse maternal and neonatal outcomes.
Examining the coupling relationship between industrial upgrading and eco-environmental system in resource-based cities in China
Authors: Lei Yu , Chen Yongxiang , Zhang Lanyue , Lu Yifu 
Published: February 2025

IntroductionThe long-term extensive development of resource-based cities makes them face problems such as resource exhaustion, industrial structure imbalance, ecological environment deterioration, which urgently need to carry out green transformation.MethodsIn this study, Entropy-CRITIC-TOPSIS model and coupling coordination degree model were constructed to estimate and analyze the coordinated development level of industrial structure upgrading and ecological environment of 19 resource-based cities in Northeast China from 2010 to 2021.ResultsThe results showed that the coupling coordination situation between industrial structure rationalization and ecological environment in 19 resource-based cities were unsatisfactory, and the proportion of uncoordinated development between industrial structure rationalization and ecological environment was as high as 89.47%. In comparison, the coupling coordination situation between industrial structure advancement and ecological environment were relatively better, with all cities’ industrial structure upgrading and ecological environment systems being basically coordinated or above.DiscussionThis suggests that resource-based cities in Northeast China should still focus on improving the rational allocation of resources, environmental protection, and coordinated development of resource utilization. The conclusion of this study provides a theoretical basis for the sustainable development of domestic resource-based cities, and can also be used as a reference for domestic and foreign resource-based cities or regions.
Water retention influences thigh skin temperature variation post-exercise: preliminary study of bioimpedance analysis and thermography data
Authors: Amato Alessandra , Petrigna Luca , Sortino Martina , Amorim Paulo Roberto S. , Musumeci Giuseppe 
Published: February 2025

ObjectivesThis study aimed to investigate the influence of body composition variables, focusing on the extracellular water level and gender difference, on infrared thermography detection during and post exercise.MethodOne hundred two participants were included in the study. Body composition was analyzed by bioimpedance, and three thermal imaging were taken before, at the end, and 5 min after a vigorous exercise. First, participants were divided by gender, and differences in skin temperature variation during exercise were highlighted. In the second analysis, the subjects were divided into three groups depending on the percentage of extracellular water. The correlation between body composition variables and skin temperature at the 3-time points was studied.Resultsan association between extracellular water (%) and basal thigh temperature both in the dominant leg (r: −0.27, p &lt; 0.01) and non-dominant leg (r: −0.26, p &lt; 0.01) was found; temperature variation analysis shows a significative temperature reduction between baseline and the end of exercise in both leg for (non-dominant: p &lt; 0.001; dominant: p &lt; 0.001) and a significative skin temperature increase after 5 min recovery, 0.14°C for the dominant leg (p &gt; 0.05) and 0.12°C for the non-dominant leg (p &gt; 0.05) considering the whole group. However, when we considered the separate group for extracellular contente the same significative decrease was found just in the lower water retention group (p &lt; 0.05) and medium water retention group (p &lt; 0.05). The high water retention group showed an opposite skin temperature trend in 5-min post-exercise recovery and had lower skin temperature at each time point compared with the other groups. The female group had lower skin temperature than the male at each time point.ConclusionWater retention could influence basal skin temperature and the temperature variation following vigorous exercise. A value of less than 45% of extracellular water should be considered for reliable use of thermal imaging. Further studies are needed to confirm this value.