bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antihyperlipidemic Activity of Leaves of Malvaviscus arboreus Dil.Ex.cav
in High-fat Diet (HFD) Induce Hyperlipidemia in Wistar Rats
Authors: Kumar Tirath , Rastogi Mansi , kaur Virender , Srivastava Rajnish 
Published: June 2024

Aim::
The present study aimed to explore the therapeutic efficacy of an ethanolic extract
of Malvaviscus arboreus Dil.Ex.cav against HFD-induced hyperlipidemia in experimental
rats.

Background::
Dietary alterations influence normal metabolic function and provide significant
risks for cardiovascular disease and oxidative stress. The likelihood of dyslipidemia is related to
the intake of HFD and is associated with increased LDL and VLDL cholesterol in humans. This
condition also increases the risk of atherosclerosis, diabetes, and hepatosteatosis.

Objective::
The objective of the present study is to determine whether the EEMA can help in reducing
elevated levels of lipids (such as cholesterol and triglycerides) in HFD-induced hyperlipidemia
in Wistar rats.

Methods::
Normal control (Group I) receives a normal standard pellet. HFD was given to all the
experimental groups for 15 days without any treatment to achieve hyperlipidemia. Except for the
negative control group, the positive control, the low dose (300 mg/kg), and the high dose (600
mg/kg), EEMA groups were treated for the next 16th to 28th days along with the HFD. The lipid
profile (TC, TG, HDL, LDL, and VLDL) and liver markers (AST, ALT, and ALP) were estimated
at the end of the study on the 29th day.

Results::
The oral administration of EEMA offered significant dose-dependent protection against
HFD-induced hyperlipidemia. It significantly improved the lipid profile and liver function biomarkers
as compared to a negative control group, with the maximum effects recorded by the
EEMA at 600 mg/kg b.w.

Conclusion::
The present study revealed that the EEMA protects against HFD-induced hyperlipidemia.
Phytoconstituents Ameliorates Alzheimer's Disease and Cognitive
Impairments: A Review of Preclinical Studies
Authors: Biswkarma Vishal Kumar , Wadhawan Swati 
Published: June 2024

Abstract::
Alzheimer's disease (AD) stands as a pressing global health challenge with limited
therapeutic options. In pursuit of alternative interventions, this review critically examines the potential
of phytoconstituents in alleviating AD-related cognitive impairments through a comprehensive
analysis of preclinical studies. The diverse and intricate pathogenesis of AD calls for
multifaceted approaches, and phytoconstituents present a promising avenue due to their multifunctional
properties. These natural compounds, derived from various plant sources, have been
shown to possess anti-inflammatory, antioxidant, and neurogenesis-promoting activities, along
with the ability to modulate amyloid-beta aggregation. A review of the literature highlights a
broad spectrum of phytoconstituents, including polyphenols, alkaloids, flavonoids, and terpenoids,
which have demonstrated neuroprotective effects in various animal models of AD. Despite
the consistency in positive outcomes across studies, challenges emerge from the variability in
dosages, administration routes, and extraction methods employed. The transition from preclinical
findings to clinical applications demands a meticulous assessment of safety, pharmacokinetics,
and dosing regimens, as well as consideration of individual patient characteristics. The review
emphasizes the need for standardized protocols in future investigations to facilitate reliable comparisons
and evidence-based conclusions. While promising, the translation of these preclinical
successes to human trials necessitates a cautious approach guided by robust scientific inquiry.
Collaboration between diverse disciplines, including botany, pharmacology, neurology, and clinical
medicine, is pivotal for refining our understanding of phytoconstituent mechanisms, optimizing
their delivery, and ultimately harnessing their potential for AD therapeutics.
Nutrients and Foods Recommended for Blood Pressure Control on Twitter in Japan: Content Analysis
Authors: Terada Marina , Okuhara Tsuyoshi , Yokota Rie , Kiuchi Takahiro , Murakami Kentaro 
Published: June 2024

Background
Management and prevention of hypertension are important public health issues. Healthy dietary habits are one of the modifiable factors. As Twitter (subsequently rebranded X) is a digital platform that can influence public eating behavior, there is a knowledge gap regarding the information about foods and nutrients recommended for blood pressure control and who disseminates them on Twitter.

Objective
This study aimed to investigate the nature of the information people are exposed to on Twitter regarding nutrients and foods for blood pressure control.

Methods
A total of 147,898 Japanese tweets were extracted from January 1, 2022, to December 31, 2022. The final sample of 2347 tweets with at least 1 retweet was manually coded into categories of food groups, nutrients, user characteristics, and themes. The number and percentage of tweets, retweets, and themes in each category were calculated.

Results
Of the 2347 tweets, 80% (n=1877) of tweets mentioned foods, which were categorized into 17 different food groups. Seasonings and spices, including salt, were most frequently mentioned (1356/1877, 72.2%). This was followed by vegetable and fruit groups. The 15 kinds of nutrients were mentioned in 1566 tweets, with sodium being the largest proportion at 83.1% (n=1301), followed by potassium at 8.4% (n=132). There was misinformation regarding salt intake for hypertension, accounting for 40.8% (n=531) of tweets referring to salt, including recommendations for salt intake to lower blood pressure. In total, 75% (n=21) of tweets from “doctors” mentioned salt reduction is effective for hypertension control, while 31.1% (n=74) of tweets from “health, losing weight, and beauty-related users,” 25.9% (n=429) of tweets from “general public,” and 23.5% (n=4) tweets from “dietitian or registered dietitian” denied salt reduction for hypertension. The antisalt reduction tweets accounted for 31.5% (n=106) of the most disseminated tweets related to nutrients and foods for blood pressure control.

Conclusions
The large number of tweets in this study indicates a high interest in nutrients and foods for blood pressure control. Misinformation asserting antisalt reduction was posted primarily by the general public and self-proclaimed health experts. The number of tweets from nutritionists, registered dietitians, and doctors who were expected to correct misinformation and promote salt reduction was relatively low, and their messages were not always positive toward salt reduction. There is a need for communication strategies to combat misinformation, promote correct information on salt reduction, and train health care professionals to effectively communicate evidence-based information on this topic.
Optimization of Spray Drying Process of Mangiferin Extract from Mango Leaf (Mangifera indica L.) and Encapsulation for Diabetes Treatment
Authors: Nguyen Ngoc Nha Thao , Vo Duc Linh , Le Thi Thanh Yen , Nguyen Thi Trang Dai 
Published: June 2024

Mangiferin is known as a major compound in mango leaves with various pharmacological effects such as antioxidant, antiviral, cancer, diabetes,... However, the poor solubility of mangiferin limits its pharmaceutical applications. Thus, this work’s major goal was to optimize the parameters of the spray-drying process in order to improve the dissolution of mangiferin in Mangiferin indica L. leaf extract and capsule formulation for diabetes treatment. Fourteen experiments were designed with Design Expert software and optimized process formulas with BC Pharsoft OPT software. Three independent variables were selected for surveying namely the ratio of mangiferin to excipients (X1), the ratio of maltodextrin in spray fluid composition (X2), and inlet air temperature (X3). The dissolution of mangiferin was shown as the percentage of this compound released within 5 minutes (Y1), 15 minutes (Y2), 30 minutes (Y3), and the percentage of hygroscopicity at 25oC (Y4). The results showed that the optimized spray drying process and formula which included the ratio of mangiferin and maltodextrin in the spray drying solution being 8.30% and 9.63%, respectively, the inlet air temperature of 156.26oC, blowing speed of 50 m3/s, pump flow of 3 mL/min possessed the dissolution of mangiferin in spray drying powder of 91.89 ± 2.43% at 30 minutes, the percentage hygroscopicity of 0.13 ± 0.13% at 25oC. The cause-effect relations and optimization of Mangiferin indica L leaf extract powder formulation were investigated and reported for the first time. The spray-dried powder capsule released more than 90% active ingredients in 30 minutes and showed significant hypoglycemic effects in inhibiting the α-glucosidase enzyme (IC 50 of 36.94 µg/mL equivalent to mangiferin in comparison with the commercial drug Glucobay (acarbose 176.09 µg/mL). In summary, the capsules containing the optimized formula of mangiferin spray-dried powder from Mangifera indica L. leaf extract have been successfully prepared and had potential antidiabetic effects in in-vitro settings.
Comparing the cognitive Flexibility and Response Inhibition Abilities in Individuals with Mild Cognitive Impairment and Older Healthy Individuals
Authors: Aradhya Abhishek Budiguppe Panchakshari , - Rajasudhakar , Kashyap Ranjitha 
Published: June 2024

Cognitive flexibility refers to the ability to switch rapidly between different responses sets. It is further sub divided into set shifting and cognitive shifting. While set shifting is considered to be automatic, cognitive shifting is considered to be conscious and strategic. Cognitive shifting can be assessed through a variety of linguistic and non-linguistic tasks. The non-linguistic tasks include stroop task, non-zero task etc. The alternating fluency task is a linguistic task, built in the same lines of generative naming. The only difference is that the participant has to rapidly alternate between two lexical categories in other words has to name a lexical item from first lexical category and then name a lexical item from the other lexical category. Response inhibition is the other executive function required for performing the alternating fluency task, as it would require the participants to inhibit the response belonging to the other lexical category. The current study was taken up with the aim of comparing cognitive shifting abilities in individuals with MCI and older individuals by employing alternating fluency task. Four lexical category combinations (animals-vehicles; birds-common objects; fruits-vegetables, colours and body parts) were considered and the task of participant was to name a lexical category from each combination (at once) within a period of 2 minutes. Each correct response was given a score of 1 when the participant could produce responses from both lexical categories given. 0 was given for partial and incorrect responses. Older participants performed better compared to participants with MCI. Individuals with MCI performed poorly as the cognitive flexibility and response inhibition are found to be compromised in these individuals.
Tratamiento de paciente bruxista con restauraciones mínimamente invasivas: reporte de caso clínico
Authors: Vargas Santana Francisco , Guedea Preciado Nora Esther , Bayardo González Daniel Eduardo , Rodríguez-Chávez Jacqueline Adelina , Curiel González Ricardo , Magaña Curiel Karina 
Published: June 2024

Introducción: el bruxismo es una condición oral asociada con numerosos problemas clínicos, se define como “hábito oral que consiste en rechinar o apretar en forma rítmica o espasmódica los dientes durante movimientos no masticatorios, lo cual puede ocasionar trauma oclusal”. Objetivos: presentar el seguimiento de un paciente con bruxismo de vigilia y del sueño, con pérdida de sustancia dental generalizada. Presentación del caso: se diagnosticó pérdida de sustancia dental generalizada asociada a bruxismo, así como dimensión vertical de oclusión disminuida. El tratamiento se dividió en 4 fases. Primera fase: Se tomaron modelos de diagnóstico, radiografías y fotografías. Segunda fase: Se evaluó el encerado mediante una maqueta de diagnóstico observando la armonía facial y aceptación del paciente. Tercera fase: Se prepararon las piezas, se tomó impresión final y se colocaron las restauraciones provisionales, las cuales se mantuvieron 2 semanas en boca para verificar la adaptación del paciente. Cuarta fase: Se cementaron las restauraciones finales y se colocó férula oclusal. El paciente tuvo una correcta adaptación a la nueva dimensión vertical de oclusión, se cumplieron los objetivos estéticos, biológicos y funcionales y se dio tratamiento a la parafunción. Conclusiones: las restauraciones mínimamente invasivas resultan ser una opción cómoda, rápida e indolora la cual cumple con los requisitos estéticos, biológicos y funcionales.
Pengolahan Buah Kelapa Menjadi Serundeng Sebagai Upaya Pemanfaatan Potensi Alam Desa Ban, Karangasem
Authors: - Gek ayu sagita widya tresna wati , Sang Ayu Made Agung Prasetiawati Djelantik  , Gusti Ngurah Oka Jiwantara  
Published: June 2024

Desa Ban, Kubu, Karangasem mempunyai keunggulan pada potensi alam yang dimiliki, yaitu pohon kelapa. Potensi alam berupa pohon kelapa di Desa Ban, Kubu, Karangasem belum dioptimalkan secara maksimal karena mayoritas masyarakat hanya memanfaatkan dengan menjualnya dalam bentuk buah kelapa, belum dijadikan produk unggulan pangan yang mampu meningkatkan nilai potensi ekonomi masyarakat desa tersebut. Tujuan dilaksanakan pengabdian ini adalah agar masyarakat bisa memanfaatkan potensi alam yang ada di desa Ban, Kubu, Karangasem agar dapat bernilai ekonomi dengan harapan kedepannya potensi alam tersebut dapat dijadikan produk unggulan pangan yang mampu meningkatkan nilai potensi ekonomi masyarakat desa Ban, Kubu, Karangasem. Kegiatan pengabdian ini berhasil menarik perhatian pemerintahan dan masyarakat Desa Ban, Kubu, Karangasem.
Pengaruh Zat Pengatur Tumbuh Atonik Dan Pupuk Bokasi Terhadap Pertumbuhan Dan Hasil Tanaman Tomat (Solanum lycopersicum L.)
Authors: I Komang Sujana  , Made Suarta  , Ketut Agung Sudewa  
Published: June 2024

This study aims to determine the interaction of Bokasi Fertilizer and Atonic Growth Regulators on the growth of tomato plants. This research was conducted in the greenhouse of the Faculty of Agriculture, Warmadewa University, JI. Ompong 24 Tanjung Bungkak, Denpasar with a height of 25 m above sea level. This research starts from August - October 2023. This experiment uses a factorial pattern Group Randomized Design (RAK) with two factors, namely: Factor I is atonic ZPT with 4 levels of concentration, namely: A0 = 0 cc 1-1, A1 = 1 cc 1-1, A2 = 2 cc 1-1, A3 = 3 cc 1-1, Factor II is bokashi fertilizer consisting of 4 concentrations, namely: B0= 0 tons / ha, B1 = 10 tons / ha, B2 = 20 tons / ha, B3 = 30 tons / ha, Thus there are 16 combination treatments, each of which is repeated 3x so that there are 48 experimental polybags. The treatment of atonic growth regulators 1 cc 1-1 tends to give the highest dry weight yield of 148.68 grams, which is not real from other treatments. The treatment of 30 tons / ha of bokasi fertilizer tends to produce the highest dry weight of 149.44 grams which is not real from other treatments. Bokasi fertilizer has a real effect (P<0.05) on the fruit diameter and no real effect (P>0.05) on other variables. The treatment of bokasi fertilizer of 30 tons / ha produces the highest fruit diameter of 3.49 cm which is not real with the treatment of fertilizer 0 tons / ha and 20 tons / ha with fruit diameters of 3.31 cm and 3.40 cm respectively, but differs markedly from the application of bokasi fertilizer of 10 tons / ha with a fruit diameter of 3.10 cm. Bocation fertilizer tends to show no real influence on the growth and yield of tomato plants which is likely due to goat manure bokashi fertilizer has not been absorbed by tomato plants optimally.
Implementation of the Plate Meal Method towards Self-Management of Type 2 Diabetes Mellitus Patients
Authors: Alda Rauza , Mulfianda Riyan , Desreza Nanda 
Published: June 2024

Plate meal is a diet therapy program for Diabetes Mellitus Type 2 patients, which may balance the blood glucose by dividing food on the plate. Improving patient self-management may difference the patients, especially those with Diabetes Mellitus type 2. This research aimed to determine the difference of the plate meal method with diet program implementation toward self-management among patients with Diabetes Mellitus type 2. This research was a quasi-experiment with pre and post-test equivalent control group methods. The population of this research was thirty patients with Diabetes Mellitus type 2 in Ulee Kareng Regional Technical Implementation Unit Health Community Center of Banda Aceh, which was divided into two groups, consisting of 15 respondents from the intervention group and 15 from the control group. The technique used in taking the samples was purposive sampling. This research was conducted in Ulee Kareng Regional Technical Implementation Unit Health Community Center from June 19 to 27, 2023. The data analysis used was a paired t-test and an independent t-test. The result of the research showed that the p-value of the paired t-test on the intervention group was 0.002. Therefore, there was a difference. The p-value of the control group was 0.369, which showed that there was no difference toward the control group, while the p-value of the independent t-test was 0.047 (p-Value ? 0,05), indicating that there was an difference between the intervention and control group after the treatment of the intervention group. The conclusion of this study is that there is a difference in the application of the plate meal method diet program towards self-management in Type 2 DM patients at the UPTD Ulee Kareng Community Health Center, Banda Aceh between the control and treatment groups.
SARS-CoV-2 in pediatric patients with immunosuppressed and neoplastic disorders from a cancer center in the Colombian Caribbean
Authors: Pertuz María , Serrano-Coll Héctor , Perez-Yepes Carlos , Mattar Salim 
Published: June 2024

Introduction: COVID-19 has caused a health, social, and health system emergency, with a dismal infection behavior in patients with special conditions, such as the immunocompromised pediatric population. Objective: To describe the clinical-epidemiological characteristics of infected SARS-CoV-2 pediatric patients with immunocompromised and neoplastic disorders. Methods: Between March 2020 and February 2022, a retrospective descriptive study was carried out in a cancer center in the Colombian Caribbean. Forty-one immunocompromised children with oncological pathologies and a diagnosis of SARS-CoV-2 infection were included. Inflammatory markers associated with severity, such as ferritin, leukocytosis, and lymphocytosis, were analyzed. Results: 24.39% of the children evaluated had sickle cell anemia and acute lymphoid leukemia (in the consolidation or maintenance phase). The most frequent symptoms were fever (31.71%), cough (29.27%), and runny nose (19.51%). The severity of the COVID-19 infection was mild in 39.02% of the cases, and 24.39% were asymptomatic. Inflammatory markers and clinical manifestations were not associated with severity. Severity was also not associated with oxygen requirements, thoracic radiological changes, or admission to the ICU (P-value >0.05). Conclusions: The results suggest that despite immunosuppression, the pediatric population did not present severe cases of COVID-19 infection.
Prevalencia del papiloma virus humano de alto riego en una población de mujeres y hombres que tienen sexo con hombres (HSH) VIH (+) atendidos en el Laboratorio Clínico VID Medellín - Colombia; durante los años 2020 a 2023
Authors: Estrada Santiago , Sánchez Paola , Arango Carolina , Salazar Karolina , López Catalina 
Published: June 2024

Objetivo: identificar la prevalencia de los VPH de alto riesgo en mujeres y en hombres que tienen sexo con hombres VIH positivos, durante el periodo comprendido entre 2020 y 2023. Materiales y método: Estudio observacional descriptivo retrospectivo, de pacientes que acudieron al Laboratorio Clínico VID. Se incluyeron todos los pacientes que llegaron con el propósito de realizarse la prueba de VPH y que cumplían con los criterios para la toma de la muestra. Resultados: el total de pacientes incluidos en el estudio fue de 2.379 mujeres y 2.078 HSH-VIH (+).Se identifica VPH-AR en 586 mujeres y 1.652 HSH-VIH (+).La frecuencia de genotipos de alto riesgo identificados fue de 0,36 % en las mujeres y de 2,52 % en los HSH VIH (+). Los genotipos de VPH más prevalentes en ambos grupos fueron: 16, 52, 58 y 68. Conclusiones: La prevalencia de VPH-AR en las mujeres fue de 26,4 % y en los hombres que tienen sexo con hombres de 79,5 %, la mayoría de los genotipos de alto riesgo presentes en mujeres se encuentran en el rango de edad entre los 30-39 años, mientras que en los HSH VIH (+) se encuentran en el rango de menor de 30 años.
Histoplasmosis y bacteremia persistente por Staphylococcus aureus meticilino-resistente asociada a derivación ventriculoperitoneal: reporte de caso
Authors: Álvarez-Ortega Carolina , Rebellon-Sanchez David E. , Marquez Juan Camilo , Vélez Juan Diego , Ramos-Ospina Natalia , Zuñiga-Restrepo Valeria , Moncada-Vallejo Pablo A. 
Published: June 2024

La histoplasmosis es una infección fúngica causada por Histoplasma ssp, que afecta principalmente el sistema respiratorio, mientras que Staphylococcus aureus resistente a la meticilina (SARM) es una bacteria notoria por ser resistente a los antibióticos y asociarse con infecciones graves. Presentamos un informe de caso de una mujer de 33 años con antecedente de hidrocefalia que se sometió a la colocación de una derivación ventriculoperitoneal (VP) y posteriormente fue llevada al servicio de urgencias debido a debilidad muscular progresiva y síntomas sugestivos de infección sistémica. Evaluaciones adicionales revelaron paquimeningitis, anomalías pulmonares y diagnósticos de histoplasmosis y bacteriemia por SARM que persistió durante varias semanas a pesar de la terapia antibiótica dirigida. La bacteriemia solo se resolvió después de que se retirara la derivación. Este caso resalta la importancia de considerar diversas etiologías, realizar investigaciones diagnósticas oportunas con un historial médico completo y adoptar enfoques de tratamiento adaptados para casos complejos que involucran infecciones concomitantes.