bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding of home care and interest level of nursing students working as home care nurses
Authors: Nur Chayati  , Riska Adellia  
Published: May 2024

Introduction: Comprehension materials in the learning curriculum allow students to think critically about nursing care while practicing in-home care. It also can foster an interest in working as a home care nurse but not all nurses students want to be home care nurses as hope. The purpose of this study is to analyze the relationship of understanding about home care with the interest level of nursing students to be home care nurses.
Methods: This study is a quantitative correlational method with a cross-sectional approach. Data were examined in the univariate and bivariate analysis with Pearson correlation. Sixty participants were recruited by using a stratified random sampling technique.
Results: This study showed that respondents have a good understanding of home care, as many as 51 respondents (85%). Also, most of the respondents are interested in working as a home care nurse, as many as 25 respondents (41.7%). The results obtained a p-value 0.000 (p<0.05) (r=0.633). This study showed that the level of understanding of nursing students is good, and the interest in working students as home care nurses is high. It can be concluded that the understanding of home care influences the work interests of nursing students to work as home care nurses.
Conclusion: The theory and concept of home care as one of the working areas of nurses should be delivered to nursing students since they are in the academic stage, and clinical exposure to home care during the nurse profession will enhance them to involve more caring people in the home care setting.
An evaluation of the relationship between the occurrence of chronic kidney disease and the use of NSAIDs
Authors: Kamri Andi Maulana , Zullies Ikawati  , Rosnani Hashim  , Fita Rahmawati  
Published: May 2024

Background: Non-steroidal Anti-Inflammatory Drugs (NSAIDs) are painkillers that Indonesians widely use. Many people use it because it is easy to get and low price. Although, the public does not pay attention to safety in its use. This study aims to determine the relationship and the level of causality between the use of NSAIDs and chronic kidney disease (CKD) events.
Methods: An observational case-control with retrospective retrieval was adopted, and the risk factors between the use of NSAIDs and CKD events were analyzed. Meanwhile, the study was conducted in Makassar city hospital with consecutive sampling from January 2017 until January 2018.
Results: The results showed that 118 patients from a total of 350 used NSAIDs, while 35 of the 175 with CKD had a history of NSAIDs. Furthermore, the data on the use of NSAIDs in these patients was 40% meloxicam and 10% mefenamic acid, and the result of the Chi-square analysis showed a p-value <0.001 and an OR of 0.277. Additionally, the possible incidence of CKD in men and women is 48.55% and 70.72%, respectively, with a history of using NSAIDs for over 3 months. It was further shown that 2 of 118 patients had side effects from CKD due to the long-term use of NSAIDs.
Conclusion: Conclusively, there is no relationship between CKD incidence and the use of NSAIDs in the community. However, some CKD side effects are related to NSAIDs, which implies that NSAIDs do not result in CKD.
Jatropha multifida L stem sap gel versus Aloe vera gel to post-gingivectomy healing process
Authors: Listari Khusnul Munika , Az-Zahra Tsarwah , Hasanah Amalia , Agistasari Yessy 
Published: May 2024

Introduction: Gingivectomy is cutting the gingiva during a gingival enlargement condition that causes an open wound in the gingiva. Jatropha multifida L gel contains active ingredients of alkaloids, flavonoids, saponins and tannins, which are thought to accelerate the wound healing process, but its use in dentistry is limited. The objective of this research is to determine the effectiveness of the application of Jatropha multifida L stem sap gel in the wound healing process post-gingivectomy in Wistar rats (Rattus novergicus) compare with Aloe vera gel (Aloe Barbadensis Miller) by using parameters the number of fibroblasts, blood vessels and the density of collagen fibers
Methods: Rats were divided into 4 groups, namely group K (Aloe vera gel), P1 (Jatropha multifida L stem sap gel 2,5%), P2 (Jatropha multifida L stem sap gel 5%) and P3 (Jatropha multifida L stem sap gel 10%). Each group was given the gel twice a day in the wound area; then the wound was observed microscopically by Haematoxylin Eosin staining to count the number of fibroblasts and blood vessels also Masson Trichrome staining to observe the density of collagen fibers on day 3 and 7.
Results: The data obtained were statistically analyzed using the One Way Anova, Dunnet and Kruskal-Wallis test. One Way Anova test shows there is a significant difference (p<0.05) in the number of fibroblasts, and the Dunnet test shows there is a significant difference (p<0.05) in the number of fibroblasts in Jatropha multifida L stem sap gel group 2.5% and 5 % on day 3. One Way Anova test shows no significant difference (p>0.05) in the number of blood vessels. The Kruskal-Wallis test shows no significant difference (p>0.05) in collagen fiber density.
Conclusion: Jatropha multifida L Stem Sap gel has the same potential as Aloe vera gel in accelerating wound healing after gingivectomy in Wistar rats.
Efficacy of transcutaneous electrical nerve stimulation on slow transit constipation in children with cerebral palsy
Authors: Soumena Rifah Zafarani , Darma Andy , Ranuh Reza Gunadi , Indra Gunawan Prastiya , Fardah Athiyyah Alpha , Rizky Sumitro Khadijah , Marto Sudarmo Subijanto 
Published: May 2024

Introduction: Slow transit constipation ended up causing persistent symptoms that do not respond to medical treatment. Children have common soiling, irregular bowel movements, and colicky abdominal pain. Treatment-resistant slow-transit constipation in children has improved with transcutaneous electrical nerve stimulation (TENS). Several studies reported that TENS therapy was successful in prolonging colonic transit time in children with chronic constipation and reported no side effects. Thus in this study, we would like to investigate the effectiveness of TENS in conjunction with standard therapies for constipated children with cerebral palsy (CP).
Method: This was a cross-section study with a consecutive random sampling technique. This study was conducted from April 2022 – October 2022, in the faculty of medicine, Universitas Airlangga, Surabaya, Indonesia. Patients from 2 until 18 years with cerebral palsy suffering from constipation with slow transit time were recognized according to Rome-IV criteria of constipation and colonic transit colon (CTT) based on radio-opaque markers, Sitzmarks®. In two treatment groups, the intervention group was given laxatives with TENS, and the control group was given laxatives without TENS. Patient records the history of defecation frequency/week, type of stool, and colonic transit colon (CTT) based on radio-opaque markers. Analyses based on statistical parametric comparisons were performed before and after therapy (paired t-test).
Result: Defecation frequency was increased significantly in the intervention group (pre 1.33 ± 0.5 vs post 3.56 +2.0 defecation/week p=0.019) compared with the control group (pre 1.9 ± 01.9 vs post 3 ± 1.8 defecation/week p=0.117). Stools got wetter after stimulation significantly in the intervention group (p = 0.02). Colonic transit was a shorter duration in the children intervention group compared to their based line (p = 0.039).
Conclusion: Transcutaneous electrical nerve stimulation can speed up colonic transit time to be considered for constipation in CP children.
Successful treatment for retinopathy of prematurity in a very preterm baby: a case report
Authors: Yulia Dian Estu , Casey Anthea 
Published: May 2024

Background: Retinopathy of prematurity (ROP) is a leading cause of childhood blindness worldwide, including in Indonesia. ROP screening and intervention are essential to establish the diagnosis, stop disease progression, and prevent retinal detachment that causes blindness. ROP treatments such as vitrectomy and laser are beneficial. This case aims to report the anatomical and functional outcomes after surgery for ROP.
Case description: A very preterm baby with 29 weeks of gestational age and birthweight of 1300 grams was referred to the pediatric ophthalmology clinic at Cipto Mangunkusumo Hospital for ROP screening. Retinal camera (RetCam®) examination revealed stage 3 ROP in the right eye (RE) and stage 4A ROP in the left eye (LE). The LE underwent a vitrectomy, while the RE underwent laser photocoagulation under general anesthesia. Upon examination under sedation (EUS) after surgery, the retina was examined using RetCam® and was found attached to the LE and regressed on the RE. The baby is able to fixate on and follow objects. However, the refraction examination showed myopia in both eyes. Glasses were prescribed due to the myopia outcome in this case.
Conclusion: Vitrectomy for stage 4A ROP and laser photocoagulation for stage 3 ROP are effective in anatomical and functional outcomes in a very preterm baby.
Factors related to mortality in geriatric patients after elective surgery: a retrospective cohort study
Authors: Mupangati Yudo Murti , Mustain  , Setyawan Henry , Riwanto Ignatius , Soejono Czeresna Heriawan , Gasem Muhammad Hussein 
Published: May 2024

Introduction: The increased number of surgery on the elderly is often followed by an increased risk of mortality rate. Identifying the risk factors of surgical death in elderly patients will be mandatory before making a decision. This study aimed to determine mortality-associated factors in older people who underwent inpatient elective surgery.
Methods: This cohort retrospective study analyzed secondary data from the medical records of geriatric patients hospitalized at Dr. Kariadi Hospital Semarang in 2020. Patients aged ≥ 60 years and who have undergone elective surgery were included. Patients with incomplete medical records, who had undergone outpatient surgery, more than one surgery, and emergency surgery, Covid-19, were excluded. A total of 382 patients met the criteria. In this study, independent variables analyzed were age, sex, nutritional status based on body mass index, functional status by Barthel, marital status, residence status, number of comorbidities according to Charlson Comorbidity Index, albumin levels, electrocardiogram (ECG) abnormalities, surgery type, and American Society of Anesthesiologists (ASA) status. The dependent variable was in-hospital mortality. In the logistic regression analysis, we identified the five most significant variables to allow for the prediction of in-hospital mortality.
Results: Residence status (p= 0.003), ECG (p= 0.001), comorbidity (p <0.0001), albumin status (p< 0.0001), and ASA status (p< 0.0001) were identified as factors that affect postoperative mortality after multivariate analysis.
Conclusion: In this study, mortality-associated factors were living alone, ECG abnormality, comorbidity > 2, hypoalbumin, and ASA > 2.
A novel preoperative scoring system to predict postoperative mortality after pancreaticoduodenectomy in pancreatic cancer patients at Dr. Soetomo General Hospital: a retrospective cohort study
Authors: Arland Chandra  , Lesmana Tomy 
Published: May 2024

Introduction: Knowing the risk of surgery before performing one is essential for informed consent and decisions making for the doctors, patients, and their families. Complexities of surgery and pancreatic cancer aggressiveness are two factors that contribute to high mortality rate in pancreaticoduodenectomy. There has been a few scoring systems developed to predict mortality after pancreaticoduodenectomy. However, external validation of these scoring systems failed to achieve good predictive value consistently. This could happen due to differences in patient demographics, variables and their cut-off, patient samples, and hospital or health care standard where these scoring systems were constructed. This study aims to develop a novel scoring system to predict postoperative mortality and to compare its performance with the existing scoring systems.
Methods: Data were collected retrospectively from all patients who underwent pancreaticoduodenectomy in Dr. Soetomo General Hospital, starting from January 2012 to October 2022. 75 patients were included based on the inclusion criteria. Multivariate logistic regression analysis was performed to select multiple risk factors correlated with in-house mortality. A novel scoring system was formed using these risk factors. We also assessed and compared the predictive value of the existing scores (Parikh, Nugroho, and WHipple-ABACUS) using the ROC curve. Chi square test with odds ratio calculation and logistic regression were used in this study.
Results: Post pancreaticoduodenectomy mortality rate was 28% (21 out of 75 patients) with 4 statistically significant risk factors. Those factors are age > 52 years. (OR 7.435; 95% CI 1.113-49.677, p = 0.038), comorbidities (OR 5.793; 95% CI 1.116-30.067, p = 0.037), American Society of Anaesthesiology (ASA) 3 (OR 8.932; 95% CI 1.329-60.022, p = 0.024), and total bilirubin > 16.6 mg/dL (OR 8.329; 95% CI 1.577-43.983, p = 0,013). These factors were used to form a novel scoring system. The predictive performance of the newly created scoring system was 0.911 (95% CI 0.823-0.965). While external validation of the existing scoring systems was as follows: Parikh 0.684 (95% CI 0.567-9.787), Nugroho 0.829 (95% CI 0.724-0.906), and WHipple-ABACUS 0.736 (95% CI 0.62-0.832).
Conclusion: The newly created scoring system uses 4 relatively easy and accessible preoperative variables to predict post-pancreaticoduodenectomy mortality. However, it still requires external validation in multicenter hospitals with large numbers of patients.
Effect of Spiramycin and Moringa leaf feeding in improving placenta, heart, histopathological neurons and glia in fetal models with toxoplasmosis
Authors: Nurinasari Hafi , Sajidan  , Bambang Purwanto  , Dono Indarto  , Didik T Subekti  , Hendrastuti Apriningsih  , Ariva Syiva’a  , Soetrisno  
Published: May 2024

Background: Toxoplasmosis is a protozoan disease caused by Toxoplasma gondii that can cause fetal abortion, stillbirth, death, or fetal and neonatal abnormalities. Spiramycin prophylactic purpose is to prevent fetal infection in toxoplasmosis. While Moringa oleifera contains bioactive compounds that benefit from treating oxidative stress and infections. This study aims to evaluate the effect of Spiramycin and Moringa leaf extract in improving the placenta, heart, histopathological neurons and glia in fetal rat models with toxoplasmosis.
Methods: An experimental study with a post-test-only control group design was done using 24 pregnant female rats divided into the control group receiving spiramycin therapy (P1) and two intervention groups that were given spiramycin and ethanol extract from Moringa leaves at a dose of 240 mg/kg body weight (P2) and combination of spiramycin and ethanol extract from moringa leaves at a dose of 420 mg/kgBW (P3). A histopathological examination was then performed.
Results: Administration of spiramycin and ethanol extract of Moringa leaves at 420 mg/kg body weight had the same histopathological examination results as spiramycin administration. In a histopathological examination of toxoplasmosis pregnant rat placenta and toxoplasmosis fetal rat heart was effective in repairing gliosis in neurons and neuroglia of toxoplasmosis rat fetuses.
Conclusion: Administration of spiramycin and ethanol extract from Moringa leaves was effective in repairing gliosis in neurons and neuroglia of toxoplasmosis rat fetuses.
The relationship between metabolic acidosis as a predictive factor of mortality in Ludwig's Angina patients at Dr. Soetomo General Hospital, Surabaya, Indonesia
Authors: Adi Alif Rakhman Prima , Wibowo Marjono Dwi , Susilo Dwi Hari 
Published: May 2024

Background: Mortality in a patient with Ludwig's Angina is usually due to prolonged sepsis. When sepsis is present, acidosis and lactate independently predict mortality in critically ill patients. Patients who develop acidosis after 6 hours are at high risk of death and should be treated more aggressively than septic patients.
Methods: A retrospective cohort study to determine the association between metabolic acidosis and mortality in Ludwig's Angina patient at Dr. Soetomo General Hospital Surabaya at Dr. Soetomo between January 2019 - December 2020. We retrospectively reviewed 42 medical records of patients with Ludwig's Angina. We collected patient data such as age, history, physical examination, blood gas analysis, surgical intervention, comorbidities, complications before surgery, and patient outcomes.
Results: We analyze a total of 42 patients. 71.40% were male, and 38.60% were in the group of 51-60 years, with a mean age of 45.73 years. 59.50% had metabolic acidosis, and 83.30% died. Based on the comorbidities, there were 28.60% with diabetes mellitus, 21.40% with dental caries and 16.70% with hypertension. A complication of hypoalbuminemia was found in 42.90%, 23.80% with sepsis, and 21.40% with acute kidney injury. Metabolic acidosis and mortality had a significant relationship with a p-value of 0.047, OR 5.00 (95% CI, 0.933-26.785). No comorbidity or complication variables impacted patient outcomes (p > 0.05 for all).
Conclusion: There was a significant relationship between metabolic acidosis and mortality of Ludwig's angina patients.
The percentage of positive biopsy cores in predicting biochemical recurrence and adverse pathology in prostate cancer patients after radical prostatectomy: a systematic review and meta-analysis
Authors: Fitra Ahmad Fathira , Yogiswara Niwanda , Djatisoesanto Wahjoe , Chung Eric , Hakim Lukman 
Published: May 2024

Background: Biochemical recurrence (BCR) occurs in more than one-third of prostate cancer (PCa) patients 10 years after radical prostatectomy. The percentage of positive biopsy cores (PPBC) obtained from prostate needle biopsy is suggested as one of the predictors of BCR. We aim to investigate the role of PPBC in predicting BCR and adverse pathology in PCa patients after RP.
Methods: A systematic search was conducted based on PRISMA guidelines from Pubmed, Scopus, and Cochrane Library databases up to July 2022. We screened studies that met our inclusion criteria and NOS (Newcastle-Ottawa Scale) was utilized as the quality assessment tool. The primary outcome was BCR measured as Hazard Ratios (HRs). The secondary outcome was adverse pathology, including positive surgical margin (PSM), Extra-prostatic disease (EPD), and seminal vesicle invasion (SVI). Review Manager®5.4 was used as the statistical analysis tool.
Results: A total of 5971 patients were included from eleven eligible studies with overall good quality scores. Eleven studies were included in the qualitative synthesis and five of them were analyzed in the meta-analysis. The pooled analysis demonstrated that higher PPBC has a 2.77 times risk of BCR (OR 2.77 (95% CI: 1.97, 3.9; p<0.00001) after RP. Similarly, it has significant results in SVI (OR 2.61 (95% CI: 1.19, 5.73; p=0.02). However, there were insignificant results in terms of EPD (p=0.17) and PSM (p=0.33).
Conclusion: This systematic review and meta-analysis (SRMA) indicate that a high PPBC is strongly correlated with a greater risk of BCR and SVI, but not EPD and PSM in patients following RP.
Unmet need for Family Planning (FP) in 7 national development areas in Indonesia
Authors: Musafaah Musafaah  , Tris Eryando  , Meiwita Paulina Budiharsana  , Martya Rahmaniati  , Hadrianti Lasari  
Published: May 2024

Introduction: Unmet need for Family Planning (FP) was conducted to measure the achievement of the FP program. Since decentralization, each region has the flexibility to implement certain policies according to regional needs, including family planning program policies. This study aimed to describe the unmet need for FP in 7 regions in Indonesia in 2018-2021.
Methods: This research is an ecological study using data derived from the National Population and Family Planning Agency Field Control Report in 2018-2021 and descriptively analyzed based on 7 development areas of the 2020-2024 National Medium-Term Development Plan. Unmet need for FP is the percentage of married couples whose wife is between the ages of 15 to 49 years and aren’t using contraception, those who still wanted children but have postponed it for up to 2 years and those who decided that they didn’t want any more children.
Result: The results showed that the unmet need for FP in the Nusa Tenggara, Kalimantan, Sulawesi, Maluku, and Papua regions continued to decline in 2018-2021. The largest decrease in unmet need for FP occurred in Papua (7.6%) while the smallest decrease occurred in Sumatra (0.9%).
Conclusion: The magnitude of the decrease in the unmet need for FP varies by region. Region-specific FP program interventions are needed to increase the need for contraception in couples of childbearing age (EFA).
Development of preconceptions health modules in adolescents based on information and communication technology
Authors: Ani Luh Seri , Darmayani I Gusti Ayu Sri , Mogi I Komang Ari , Utami Ni Wayan Arya 
Published: May 2024

Background: Preconception health is a behavioral and social health intervention for women and couples before conception occurs. Intervention starts from adolescence to improved health and readiness in pregnancy. This research is aimed at the development of preconception health modules for adolescents based on Information and Communication Technology (ICT).
Method: Qualitative study of exploration conducted on adolescents in the working area of Sidemen Health Center data collection was conducted in August 2020 against 4 informants consisting of 2 adolescents, 1 head of Public Health Center, and 1 obstetrician specialist. Data is collected by in-depth interview methods online. The data of the results of the study is analyzed thematically.
Result: The results of the interview obtained 4 (four) themes that are preconception health problems in adolescents, the content of the material of modules, methods of dissemination of information and the place of preconception health services. The teen had never heard of preconception health. Suitable materials presented in the preconception health module in adolescents are the introduction of reproductive devices, menstrual cycles, pregnancy cycles, premarital screening preparations, and preconception health interventions. Preconception health services are provided in private health services, hospitals and public health centers. Nevertheless, preconception health services in adolescents have not been optimally provided. Precisely the media chosen in the dissemination of knowledge about preconception health is face-to-face, lectures, video and book.
Conclusion: Based on this, it can be concluded that this module is expected to improve the teen's knowledge of preconception health.