bluuebunny/crossref_metadata_2025_split huggingface dataset:
NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections
Authors: Kumar Himanshu , Pandey Surya , Zou Jian , Kumagai Yutaro , Takahashi Ken , Akira Shizuo , Kawai Taro 
Published: December 2010

Abstract
Nucleotide-binding domain and leucine rich repeat containing gene family receptors (NLRs) are cytosolic proteins that respond to a variety of pathogen and host components to induce inflammatory cytokines. NLRC5 is a recently identified member of the NLR family that has been implicated in positive and negative regulation of antiviral innate immune responses. To clarify whether NLRC5 controls antiviral innate immunity in vivo, we generated NLRC5-deficient mice. Macrophages and dendritic cells derived from NLRC5-deficient mice induced relatively normal levels of IFN-β, IL-6, and TNF-α after treatment with RNA viruses, DNA viruses, and bacteria. The serum cytokine levels after polyinosinic-polycytidylic acid infection were also comparable between control and NLRC5-deficient mice. NLRC5 overexpression promoted IL-1β production via caspase-1, suggesting that NLRC5 constitutes an inflammasome. However, there was no reduction of IL-1β in NLRC5-deficient cells in response to known inflammasome activators, suggesting that NLRC5 controls IL-1β production through an unidentified pathway. These findings indicate that NLRC5 is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions.
Training for Optimal Performance Biofeedback Program: A Cooperative Program Between East Carolina University and the United States Marine Corps Wounded Warrior Battalion East
Authors: Russoniello Carmen , Fish Matt , Parks Jennifer , Rhodes John , Stover Bennie , Patton Holly , Gold Ginger , Maes Tami 
Published: December 2010

Abstract
The signature wounds of the Iraq War are traumatic brain injury and post traumatic stress disorder (PSTD). Due to an emergent need to address the symptoms of these wounds in returning Marines and navy corpsmen, a memorandum of understanding between the U.S. Marine Corps and East Carolina University's Psychophysiology Lab and Biofeedback Clinic was signed and training services were begun in February 2008. The Training for Optimal Performance program involves a biofeedback circuit-training method in which marines and navy corpsmen participate in a graded exposure protocol that includes virtual reality, cognitive retraining, neurofeedback, heart rate variability, and relationship and resiliency training. Preliminary results indicate that this approach is effective in ameliorating symptoms of traumatic brain injury and PTSD.
Psychophysiologic Assessment and Combat Post Traumatic Stress Disorder
Authors: Pyne Jeffrey M. , Gevirtz Richard 
Published: December 2010

AbstractPost traumatic stress disorder (PTSD) is a common mental health outcome associated with combat operations. Since October 2001, more than 1.6 million U.S. troops have deployed as part of Operation Enduring Freedom or Operation Iraqi Freedom. Current estimates for postdeployment post-traumatic stress disorder in Operation Enduring Freedom and Operation Iraqi Freedom veterans range from 5%–30%. This paper will briefly review a series of new and ongoing projects that utilize psychophysiologic assessment for patients with Operation Enduring Freedom or Operation Iraqi Freedom combat-related PTSD. Two treatment studies are supported by the Office of Naval Research, one assessment study is supported by the Veterans Health Administration, and a second assessment study is supported by the Department of Defense. Psychophysiologic reactivity is not new to combat-related PTSD, but there are new technologies that may enhance our ability to assess and understand this aspect of the condition. Papers describing the outcomes of these studies will be forthcoming.
Post Traumatic Stress Disorder—The Neurofeedback Remedy
Authors: Othmer Siegfried , Othmer Susan F. 
Published: December 2010

Abstract
The application of neurofeedback to post traumatic stress disorder (PTSD) in returning veterans is described herein and is illustrated with two case histories. Initially, frequency-based electroencephalogram training was employed to promote functional recovery, in the manner of the traditional sensorimotor rhythm/beta approach. An optimization procedure was employed in which the reinforcement frequency is tailored to the client on the basis of symptom response, with particular regard for the regulation of arousal. Low frequencies, down to .01 Hz, have been found especially useful in the remediation of post-traumatic stress disorder. This training was complemented with traditional alpha-theta work as pioneered at the Menninger Foundation and by Peniston. The objective here is experiential, because prior traumas typically are revisited in a nonforced, nontraumatic manner. The benign witnessing of traumas consolidates the experience of safety for which the prior training laid the groundwork. Collectively, this approach has been found to be much better tolerated than traditional exposure therapies. In addition, it is helpful in the shedding of substance dependencies that are common in treatment-resistant PTSD
Post Traumatic Stress Disorder in Police and Military Personnel: Assessment and Treatment Methods from Psychophysiology and Neuroscience—Essential Preliminary Information
Authors: Carmichael John A. 
Published: December 2010

Abstract
This article presents the clinical approach developed by a Canadian biofeedback practitioner for the assessment and treatment of police and military clients, especially those with post traumatic stress disorder (PTSD). The author conducted a clinical practice for more than 25 years primarily with male police and military clients. He examines the impact on treatment effectiveness of a number of factors, such as how police and military clients differ from civilian populations, the definition of trauma in this population, Diagnostic and Statistical Manual of Mental Disorders (4th edition; DSM-IV) diagnostic criteria, the assessment of post-traumatic stress disorder, risks and coping factors, consequences of PTSD, DSM-IV conundrums, epidemiology, and other reactions to traumatic events.
Neurofeedback in Work With Refugee Trauma: Rebuilding Fragile Foundations
Authors: Aroche Jorge , Tukelija Sejla , Askovic Mirjana 
Published: December 2010

Abstract
The authors describe the Service for the Treatment and Rehabilitation of Torture and Trauma Survivors (STARTTS), established by the Australian government to provide specialized services for the many torture and trauma survivors accepted as refugees in Australia. Of the clients served by STARTTS, 30% present with post traumatic stress disorder. The authors report on the integration of neurofeedback into the psychotherapy provided to these individuals.
The Importance of Electroencephalogram Assessment for Autistic Disorders
Authors: Coben Robert 
Published: December 2010

Abstract
Autistic disorders are a set of complex syndromes that lead to challenges impacting communication, behavior repertoire, and social skills. The etiology of autism is unknown but is likely epigenetic in nature. It is likely associated with an inflammatory process leading to neuroinflammation in early childhood. Autistic disorders include seizures in approximately one-third of the cases and there are often regions of brain dysfunction associated with neural connectivity anomalies. The electroencephalogram (EEG) is presented as a premiere tool to assess these difficulties due to its' non-invasive nature, availability and utility in detailing these difficulties. Techniques for seizure detection, monitoring, and tracing their propagation are shown. Similar approaches can then be utilized for assessing EEG oscillations, which are at the heart of these neuronal regulation dysfunctions. Autistic disorders are clearly associated with regions of dysfunction and quantitative electroencephalogram strategies for assessing these impairments are shown. These include techniques for increasing the specificity and spatial resolution of the EEG such as source localization and independent components analysis. Lastly, advanced methods for assessing the neural connectivity problems that underlie the difficulties of these children are presented. EEG assessment, when processed and analyzed with the most advanced techniques, can be invaluable in the evaluation of autistic disorders.
Limb Position Biofeedback for Patellofemoral Pain
Authors: Ming Wong Yiu 
Published: December 2010

Abstract
Individuals with excessive internal hip rotation and knee valgus during functional movement often develop abnormal lateral patellar tracking, sometimes resulting in anterior knee pain. A configuration of currently available biofeedback instruments, including an electronic goniometer, can provide feedback on limb position, which is useful in correcting the knee valgus. The article reports on the use of this biofeedback system with three individuals with measurable knee valgus, producing a remediation of the limb angle in each case.
Keep Cell Phones and PDAs Away From EMG Sensors and the Human Body to Prevent Electromagnetic Interference Artifacts and Cancer
Authors: Lin I-Mei , Peper Erik 
Published: December 2010

Abstract
Cell phones produce electromagnetic interference (EMI), which can cause artifacts in physiological recordings and be misinterpreted by the clinician. This study investigated the possible effect of EMI (electrical artifact) on physiological recordings when cell phones are activated/ringing. The procedure consisted of placing the cell phone at varying distances from surface electromyographic sensors. Depending on the orientation of the cell phone's antenna, the EMI produced an artifact in the physiological signal for up to 175 cm (6 ft) that can be misinterpreted by the therapist. To avoid EMI artifacts, clients and therapists should turn off their cell phones when recording physiological signals. This means turning the cell phone off and not just switching it to vibrate. In addition, recent epidemiological studies suggest that long-term intensive cell phone use may increase the risk of gliomas, auditory tumors, and salivary tumors on the side of the head to which the person places the cell phone. Thus, to reduce artifacts and biological harm, the authors recommend keeping the cell phone away from the body and the biofeedback equipment.
Ethical Treatment of Traumatic Brain Injury
Authors: Striefel Sebastian “Seb” 
Published: December 2010

Abstract
Traumatic brain injury is a frequently occurring event. Often it is not diagnosed in a timely manner. Neurofeedback interventions have not yet been recognized as a treatment of choice. This lack of acceptance of neurofeedback as a treatment of choice may well be due to a scarcity of published control group studies. In addition, the use of the quantitative electroencephalography, one of the most promising diagnostic and treatment planning tools, has been opposed by the American Academy of Neurology (AAN). Yet sufficient clinical and published research data exist to warrant the use of the quantitative electroencephalography as a supplemental tool for diagnostic and treatment planning purposes and the use of various neurofeedback interventions for overcoming many of the symptoms of traumatic brain injury. Practitioners must remain current on both clinical and research data if they are to practice both ethically and competently. In addition, they must attend to other ethical issues such as informed consent, competence, and practice guidelines and standards.
The Elusive Nature of Mild Traumatic Brain Injury
Authors: Swatzyna Ronald J. 
Published: December 2010

Abstract
The author discloses a personal history of undiagnosed mild traumatic brain injury (MBTI) and identifies a typical course and progression of this condition. He advocates a careful inquiry for possible head injury whenever the clinical history shows an original period of normal functioning, a progression of disturbance over time, multiple diagnoses, and poor response to treatment with medication. He discusses the use of quantitative electroencephalography (QEEG) in assessing possible mild traumatic brain injury, describes typical features of quantitative electroencephalography in mild traumatic brain injury, and cautions about the frequency of false negatives. He provides two case histories showing the progression of disturbing cognitive, personality, and impulse control problems following early head injuries.
Ethical Behavior in Medical Settings
Authors: Striefel Sebastian “Seb” 
Published: December 2010

Abstract
Medical schools have recognized and endorsed integrative health care. As such, integrated care is becoming more common. Biofeedback practitioners already trained to work in medical settings and those willing to be so trained have a real opportunity to expand their base of services because self-regulation is an important part of integrated care and lifestyle change. Working in medical settings requires a broad base of knowledge and skill, including an understanding of both the formal and informal rules that govern activities in such settings. Having a mentor or supervisor who already possesses the requisite skills can be most useful in helping the practitioner acquire the needed knowledge and skills and to make a shift from focusing on pathology to one of promoting good physical and mental health. Issues of competence, informed consent, and confidentiality must also be addressed and often in ways not common in other settings.
Biofeedback Certification Institute of America Goes Global
Authors: Shaffer Fred , Crawford Judy 
Published: December 2010

Abstract
As biofeedback and neurofeedback achieve greater worldwide recognition, there is increased demand for international education and training standards. This article discusses the promise of international biofeedback and neurofeedback, challenges to the growth of international certification, and the Biofeedback Certification Institute of America initiatives to eliminate the obstacles to both U.S. and international certification.
A Single-Participants Investigation of the Effects of Various Biofeedback-Assisted Breathing Patterns on Heart Rate Variability: A Practitioner's Approach
Authors: Edmonds William A. , Kennedy Tom D. , Hughes Philip A. , Calzada Pablo J. 
Published: December 2010

AbstractThe objective of this study was to define specific breathing patterns and examine the effects these patterns have on indicators of heart rate variability. Perceived accounts of ease and comfort in relation to the patterned breathing applications also were assessed. A breathing pattern is the within-cycle respiratory timing or the ratio between the inspiration and expiration of breath, including the pause time at the top of the inspiration and at the bottom of the expiration. The within-participants analysis (N  =  14), including the subjective components, revealed significant differences and illuminated the strength of the effects the varied breathing patterns had on each participant.
Chocolate: Finger Licking Good An Economic and Tasty Temperature Feedback Device
Authors: Peper Erik , Johnston James , Christie Anna 
Published: December 2010

Abstract
Peripheral temperature can be monitored with various equipment ranging from digital or glass thermometers to mood rings. This article reports on an additional “yummy” temperature feedback approach, milk or dark chocolate, as an indicator of successful hand warming. The chocolate feedback was discovered initially by a trainee to reduce symptoms associated with syringomyelia. In addition, the article summarizes data demonstrating that hand warming is easily learned. Using a thermometer, 219 participants—students and physical therapists—rapidly warmed their hands an average of 10.1°F when guided with imagery. For the subset of 106 university students, their subjective stress levels decreased by 49% as their hands warmed. Regardless of the technique, hand warming provides a useful demonstration that voluntary self-control is possible.
Garbage In; Garbage Out—Identify Blood Volume Pulse (BVP) Artifacts Before Analyzing and Interpreting BVP, Blood Volume Pulse Amplitude, and Heart Rate/Respiratory Sinus Arrhythmia Data
Authors: Peper Erik , Shaffer Fred , Lin I-Mei 
Published: December 2010

Abstract
Blood volume pulse is a popular method for monitoring the relative changes in peripheral blood flow, heart rate, and heart rate variability. This article stresses the danger of blindly interpreting measures like heart rate, which are derived from blood volume pulse, without close inspection of the raw blood volume pulse signal. The authors identify common sources of signal contamination and recommend practical precautions and treatment of artifacts.
Biofeedback Certification Institute of America Certification for Academics and Technicians
Authors: Shaffer Fred , Neblett Randy , Crawford Judy 
Published: December 2010

Abstract
Feedback from Biofeedback Certification Institute of America (BCIA) certificants and noncertificants has resulted in the expansion of our certification programs and simplification of our lapsed certification policy. This article discusses our new Academic and Technician-Level Certifications, how professionals who have allowed their credential to lapse may be reinstated, and how these innovative policies help to achieve BCIA's mission.
Cortical Cartography
Authors: Kaiser David A. 
Published: December 2010

Abstract
Architecture is one part science, one part craft, and two parts art.—David Rutten
This article describes the investigation of structural-functional associations in the brain. Using light microscopy in 1909, Brodmann divided the human and primate brains into dozens of areas based on cell types and distributions, which has since been supplemented by a 3-dimensional coordinate system, an xyz system of millimeter distances. A number of electroencephalograph tomographic (volume) solutions exist, and this article explains the Brodmann montage developed by the author using the spherical harmonic expansion solution by Pascual-Marqui. The author describes his approach to training specific Brodmann areas with electroencephalograhic operant conditioning or feedback.
Uncommon Surface Electromyography
Authors: Bolek Jeffrey E. 
Published: December 2010

Abstract
Surface electromyography (SEMG) can be used as a tool to help gain the return/discovery of motor function in those with disabilities. This article presents the case of “Joey,” an 18-month-old toddler. An already challenging case due to age is made even more difficult considering his genetically based multiple impairments. SEMG provided a window of opportunity, previously unavailable, to allow Joey to demonstrate the new motor skills that he was capable of learning.
Surface Electromyography Biofeedback Training to Address Muscle Inhibition as an Adjunct to Postoperative Knee Rehabilitation
Authors: Neblett Randy , Perez Yoheli 
Published: December 2010

Abstract
Following a knee injury and surgery, pain-related and fear-related muscle inhibition can interfere with rehabilitation and may contribute to the development of chronic pain. Surface electromyography biofeedback can help patients identify and overcome muscle inhibition during physical therapy exercises, so that normal muscle strength and range of motion can be regained.
Future Directions in Surface Electromyography
Authors: Arena John G. 
Published: December 2010

Abstract
The use of surface electromyography (SEMG) has increased exponentially in the past four decades. SEMG is one of the most widespread measures employed today in psychophysiological assessment and one of three primary biofeedback modalities. This article briefly outlines three areas that the author believes are important for SEMG to address if it is to continue to flourish in the future: applications in telehealth, the use of telemetry and ambulatory monitoring, and studies on the stability or reliability of surface electromyography.
Anwendungen des endogenen Thrombinpotenzials
Authors: Wilkens M. 
Published: December 2010

SummaryAn overview is given on the method and the applications of thrombin generation assays. Thrombin generation assays provide a tool which can be used to trace the entire thrombin formation and inactivation of a plasma sample. Therefore they are principally different from traditional global assays like PT and aPTT and promise new opportunities for the assessment of bleeding or thrombotic risks.
Stellenwert der Thrombelastometrie für das Monitoring von Faktor XIII
Authors: Sanders J. O. , Friedrich K. , Gerlach R. , Platz J. , Miesbach W. , Hanke A. A. , Hofstetter C. , Weber C. F. 
Published: December 2010

SummaryRecently published studies give evidence, that an increased maximum lysis in the APTEM® – test (ML60 > 12%) of the ROTEM® (Tem International GmbH, Munich, Germany) might indicate a factor XIII deficiency (FXIII < 70%). It was the aim of this study to investigate the feasibility of thrombelastometric measurements with the ROTEM device to reflect the isolated influence of FXIII on clot stability and therefore to indicate potential factor XIII deficiencies. Patients, method: After approval by the local Scientific and Ethic Review Board, 26 consecutive patients, scheduled for elective craniotomy for tumour resection, were prospectively enrolled into this study. Blood samples were taken for conventional laboratory coagulation analyses, FXIII analyses and thrombelastometric measurements (EXTEM, FIBTEM and APTEM tests) after induction of general anaesthesia (T1), before skin incision (T2) as well as at (T3) and 24 hours after (T4) postoperative admission to ICU, respectively. Statistical analyses included Spearman rank order correlations and multiple linear regressions. Results: FXIII concentrations did not correlate with the ML60 in the APTEM test at any measuring point. Neither platelet count nor fibrinogen nor FXIII concentrations were of predictive value for ML60 of the APTEM test. Conclusion: The results lead to the assumption that thrombelastometric measurements may not be appropriate for the perioperative monitoring of FXIII concentration.
Neue Ansätze und Indikationen zur Plättchenfunktionsdiagnostik in der Kardiologie
Authors: Ivandic B. , Frey N. 
Published: December 2010

SummaryInhibiting platelet function is a key therapeutic principle in cardiology because platelets play a pivotal role in triggering cardiovascular events. In addition to acetylsalicylic acid, a cyclooxygenase inhibitor, ADP-receptor blockers are frequently used for anti-platelet therapy. This therapy does not abolish platelet activation and aggregation. Platelets may still be activated by alternative routes such as the thrombin receptor-mediated pathway. New, more potent inhibitors of platelet function continue to lower the risk of ischaemic events but several trials and clinical registries have also shown that this advantage was frequently offset by an increased risk of bleeding complications. As a consequence, the individual risk of ischaemia and bleeding of a patient must be taken into consideration to select the platelet inhibitor offering the best benefit-risk ratio. Modern laboratory diagnostics may help to achieve this goal by complementing functional platelet tests with pharmacogenomic analyses consistent with the idea of „personalized medicine“.