bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related conditions among long-term cancer survivors diagnosed in adolescence and young adulthood (AYA): results of the SURVAYA study
Authors: Janssen Silvie H. M. , Vlooswijk Carla , Bijlsma Rhodé M. , Kaal Suzanne E. J. , Kerst Jan Martijn , Tromp Jacqueline M. , Bos Monique E. M. M. , van der Hulle Tom , Lalisang Roy I. , Nuver Janine , Kouwenhoven Mathilde C. M. , van der Graaf Winette T. A. , Husson Olga 
Published: May 2024

Abstract
Background
With 5-year survival rates > 85%, gaining insight into the long-term and late health-related conditions of cancer survivors diagnosed in adolescence and young adulthood is of utmost importance to improve their quantity and quality of survival. This study examined the prevalence of and factors associated with, patient-reported health-related conditions and their latency times among long-term adolescent and young adult (AYA) cancer survivors.

Methods
AYA cancer survivors (5–20 years after diagnosis) were identified by the population-based Netherlands Cancer Registry (NCR), and invited to participate in the SURVAYA questionnaire study. Participants reported the prevalence and date of diagnosis of health-related conditions. Clinical data were retrieved from the NCR.

Results
Three thousand seven hundred seventy-six AYA cancer survivors (response rate 33.4%) were included for analyses. More than half of the AYAs (58.5%) experienced health-related conditions after their cancer diagnosis, of whom 51.4% were diagnosed with two or more conditions. Participants reported conditions related to vision (15.0%), digestive system (15.0%), endocrine system (14.1%), cardiovascular system (11.7%), respiratory system (11.3%), urinary tract system (10.9%), depression (8.6%), hearing (7.4%), arthrosis (6.9%), secondary malignancy (6.4%), speech-, taste and smell (4.5%), and rheumatoid arthritis (2.1%). Time since diagnosis, tumor type, age at diagnosis, and educational level were most frequently associated with a health-related condition.

Conclusions
A significant proportion of long-term AYA cancer survivors report having one or more health-related conditions.

Implications for cancer survivors
Future research should focus on better understanding the underlying mechanisms of, and risk factors for, these health-related conditions to support the development and implementation of risk-stratified survivorship care for AYA cancer survivors to further improve their outcomes.

Clinical trials registration
NCT05379387.
Modeling Zinc Absorption in the Adult Population of Colombia: Insights for Nutritional Evaluation and Intervention Strategies
Authors: Alvarez-Bustamante José Alexander , Muñoz Angélica María 
Published: May 2024

AbstractZinc is a vital trace element, yet its deficiency is common in various populations. This study addresses the gap in understanding zinc intake and its relationship with key nutritional parameters in a Colombian population. We analyzed data from 12,987 individuals, focusing on the daily intake of zinc, phytate, protein, and calcium, and used the phytate/zinc molar ratio as an input parameter in the Miller et al. (2013) model. This model was employed to estimate the total absorbed zinc (TAZ) and the fractional absorption of zinc (FAZ). Our findings highlight a general trend towards insufficient intake compared to the standards of the Institute of Medicine (IOM) and Colombia, with a significant percentage of the population falling below the estimated average requirement (EAR) and recommended daily allowance (RDA) for zinc, underscoring the need for targeted nutritional strategies. Our study contributes to a broader understanding of zinc nutrition and public health implications in Colombia, providing a basis for future dietary guidelines and health interventions.
Tumor microenvironment and clinical efficacy of first line immunotherapy-based combinations in metastatic renal cell carcinoma
Authors: Sammarco Enrico , Rossetti Martina , Salfi Alessia , Bonato Adele , Viacava Paolo , Masi Gianluca , Galli Luca , Faviana Pinuccia 
Published: May 2024

AbstractThe impact of tumor microenvironment (TME) in influencing clinical response to first-line immune checkpoint inhibitor (ICI)-based treatment in advanced renal cell carcinoma (RCC) is unclear. Immunohistochemistry (IHC) could identify biomarkers related to immune checkpoints and immune cell population. This study retrospectively characterized TME from 28 RCC patients who received first line ICI-based therapy through IHC assessment of selected markers and explored preliminary evidence about their possible correlation with treatment efficacy. We found a significantly higher count of CD80+, CD163+ cells and their ratio in RCC with clear cell component compared to those without clear cell features; additionally, patients with metastatic disease at diagnosis were associated with higher expression of CD163+ cells, while higher count of CD4+ cells and CD4+/CD8+ ratio were found in RCC with sarcomatoid features. Patients achieving partial or complete response were associated with lower expression of CD163+ cells (median 28 vs 47; p = 0.049). Furthermore, lower expression of CD163+ was associated with better PFS (median PFS 20.0 vs 4.7 months; HR 0.22 p = 0.011) and OS (median OS NR vs 14.4 months; HR 0.28 p = 0.036). A longer OS was reported in PD-L1 CPS negative patients (median OS NR vs 11.8 months; HR 0.20 p = 0.024). High infiltration of CD163+ macrophages, who typically present “anti-inflammatory” M2-like phenotype, could identify a subgroup of patients with poor survival after receiving first-line ICI.
Efficacy and safety of robotic versus laparoscopic liver resection for hepatocellular carcinoma: a propensity score-matched retrospective cohort study
Authors: Li He , Meng Lingzhan , Yu Simiao , Zheng Haocheng , Yu Lingxiang , Wang Hongbo , Ren Hui , Li Hu , Zhang Xiaofeng , Wang Zizheng , Yu Peng , Hu Xiongwei , Yang Muyi , Yan Jin , Shao Yanling , Cao Li , Ding Xia , Hong Zhixian , Zhu Zhenyu 
Published: May 2024

Abstract
Background
Evidence concerning long-term outcome of robotic liver resection (RLR) and laparoscopic liver resection (LLR) for hepatocellular carcinoma (HCC) patients is scarce.

Methods
This study enrolled all patients who underwent RLR and LLR for resectable HCC between July 2016 and July 2021. Propensity score matching (PSM) was employed to create a 1:3 match between the RLR and LLR groups. A comprehensive collection and analysis of patient data regarding efficacy and safety have been conducted, along with the evaluation of the learning curve for RLR.

Results
Following PSM, a total of 341 patients were included, with 97 in the RLR group and 244 in the LLR group. RLR group demonstrated a significantly longer operative time (median [IQR], 210 [152.0–298.0] min vs. 183.5 [132.3–263.5] min; p = 0.04), with no significant differences in other perioperative and short-term postoperative outcomes. Overall survival (OS) was similar between the two groups (p = 0.43), but RLR group exhibited improved recurrence-free survival (RFS) (median of 65 months vs. 56 months, p = 0.006). The estimated 5-year OS for RLR and LLR were 74.8% (95% CI: 65.4–85.6%) and 80.7% (95% CI: 74.0–88.1%), respectively. The estimated 5-year RFS for RLR and LLR were 58.6% (95% CI: 48.6–70.6%) and 38.3% (95% CI: 26.4–55.9%), respectively. In the multivariate Cox regression analysis, RLR (HR: 0.586, 95% CI (0.393–0.874), p = 0.008) emerged as an independent predictor of reducing recurrence rates and enhanced RFS. The operative learning curve indicates that approximately after the 11th case, the learning curve of RLR stabilized and entered a proficient phase.

Conclusions
OS was comparable between RLR and LLR, and while RFS was improved in the RLR group. RLR demonstrates oncological effectiveness and safety for resectable HCC.
Thalamic Nucleus Reuniens Glutamatergic Neurons Mediate Colorectal Visceral Pain in Mice via 5-HT2B Receptors
Authors: Li Di , Du Han , Qu Shu-Ting , Wu Jing-Lai , Li Yong-Chang , Xu Qi-Ya , Chen Xia , Dai Xiao-Xuan , Xu Ji-Tian , Wang Qian , Xu Guang-Yin 
Published: May 2024

AbstractIrritable bowel syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain and visceral hypersensitivity. Reducing visceral hypersensitivity is the key to effectively relieving abdominal pain in IBS. Increasing evidence has confirmed that the thalamic nucleus reuniens (Re) and 5-hydroxytryptamine (5-HT) neurotransmitter system play an important role in the development of colorectal visceral pain, whereas the exact mechanisms remain largely unclear. In this study, we found that high expression of the 5-HT2B receptors in the Re glutamatergic neurons promoted colorectal visceral pain. Specifically, we found that neonatal maternal deprivation (NMD) mice exhibited visceral hyperalgesia and enhanced spontaneous synaptic transmission in the Re brain region. Colorectal distension (CRD) stimulation induced a large amount of c-Fos expression in the Re brain region of NMD mice, predominantly in glutamatergic neurons. Furthermore, optogenetic manipulation of glutamatergic neuronal activity in the Re altered colorectal visceral pain responses in CON and NMD mice. In addition, we demonstrated that 5-HT2B receptor expression on the Re glutamatergic neurons was upregulated and ultimately promoted colorectal visceral pain in NMD mice. These findings suggest a critical role of the 5HT2B receptors on the Re glutamatergic neurons in the regulation of colorectal visceral pain.
A Screening Instrument for Trauma-Related Behavior Among Young Primary School Students: Development and Validation of the RaPTOSS
Authors: Leeuwestein Hanneke , Kupers Elisa , Boelhouwer Marieke , Tondera Paul , van Dijk Marijn 
Published: May 2024

AbstractThis article reports on the development and psychometric evaluation of a new teacher observation instrument to systematically assess young primary school students’ well-being and detect potential indicators of psychological trauma, the RaPTOSS: Risk and Protective factors Trauma Observation School Situations. The RaPTOSS is developed specifically for preschool and early primary school teachers, because of the limited abilities their young students have to verbally reflect and report on their well-being and stressful experiences. We examined the factor structure, internal consistency, convergent validity and criterion validity of the RaPTOSS in a sample of 406 4- to 8-year-old regular education students. Exploratory factor analyses yielded a four-factor structure for the risk items with the following factors: Withdrawn, Dysphoria, Destructive and Inattentive. The protective factor items revealed a four-factor structure closely aligning the theoretical factor structure: Safety and Relations, Self-Image, Everyday Life and Self-Regulation. All factors exhibited good to excellent internal consistency. Correlations between the RaPTOSS and existing measures of psychosocial well-being without a specific focus on trauma-related behavior demonstrated good convergent validity. Criterion validity was supported, as indicated by moderate to large positive correlations between teacher worries about a student and RaPTOSS risk factors, and moderate to large negative correlations between teacher worries and RAPTOSS protective factors. We conclude that the RaPTOSS is a promising measure for trauma-informed teaching and research, although future research is needed to establish its psychometric qualities in specific samples such as children diagnosed with PTSD and refugee children.
Developing a 3D hydrostratigraphical model of the emerged part of the Pelotas Basin along the northern coast of Rio Grande do Sul state, Brazil
Authors: Marquetto Luciano , Jüstel Alexander , Troian Guilherme Casarotto , Reginato Pedro Antonio Roehe , Simões Jefferson Cardia 
Published: May 2024

AbstractThe coastal plain of Rio Grande do Sul state, in Brazil, is highly vulnerable to expected changes in sea level, while having an increasing population and consequently increasing water demands. Adequate management is essential to restrain contamination, depletion and salinization of the region’s aquifers considering current and future challenges, but geologic knowledge is essential to guide groundwater sustainable practices. To contribute to this discussion, this work integrated existing geological data from the northern coast of Rio Grande do Sul state to create a three-dimensional representation of the main hydrostratigraphical units of the region and its relation to the basement rocks, expanding the current knowledge of the coastal aquifer system. A review of existing data was carried out, consisting of 307 borehole logs from 13 municipalities inside the area of interest, as well as 19 vertical electrical soundings and 37 logs from oil and coal exploratory drillings, that resulted in 315 input points for the model. This work builds up on the conceptual model previously developed for the area, that defined four hydrostratigraphical units for the region, and was able to constrain the geometries of the main aquifers (unit 1 and 3) and aquitards (unit 2 and 4) and their relation to the basement rocks, showing them to be more heterogeneous in thicknesses and extent than previously thought. In addition, this work was able to model what could be a fifth hydrostratigraphical unit, that strongly differs from the other four and could be an indication of the alluvial fans previously described in the literature.
Birational reparameterizations of surfaces
Authors: Caravantes Jorge , Pérez-Díaz Sonia , Sendra J. Rafael 
Published: May 2024

AbstractGiven a unirational parameterization of a surface, we present a general algorithm to determine a birational parameterization without using parameterization algorithms. Additionally, if the surface is assumed to have a birational parameterization with empty base locus, and the input parameterization is transversal, the degree of the solution is determined in advance and the dimension of the space of solutions is reduced. As a consequence, for these cases, we present a second faster algorithm.
MRI-prostaat voorafgaand aan het eerste consult: efficiënt? Of niet geïndiceerd?
Authors: Maas Daniel C. , Buddingh K. Tim , Oldenburg Philip , de Walle Steven F. , Wolterbeek Derek W. , de Vries Remco R. 
Published: May 2024

Samenvatting
Introductie
Met het oog op efficiëntie en patiëntvriendelijkheid zijn we in 2020 begonnen met een pilotonderzoek waarbij we een upfront MRI maken bij patiënten jonger dan 75 jaar en een PSA (prostaatspecifiek antigeen) boven de 5 ug/L. Met dit onderzoek willen wij evalueren hoeveel MRI’s niet zijn geïndiceerd op basis van de prostaatwijzer (Rotterdam Prostate Cancer Risk Calculator (RPCRC- 3/4)).

Materiaal en methoden
We includeerden 197 patiënten. Een MRI beschouwden we als overbodig indien het risico op het detecteren van prostaatkanker bij biopsie < 12,5% was en het risico op hooggradig of gevorderd prostaatkanker < 4% was.

Resultaten
Van de 197 mannen met upfront MRI waren er 50 volgens de prostaatwijzer niet geïndiceerd (26%). Binnen de categorie PSA 5 tot 7 waren 34/74 (46%) van de MRI niet geïndiceerd. Binnen de categorie PSA > 7 waren 16/123 (13%) van de MRI’s niet geïndiceerd.

Conclusie
Het verrichten van een MRI-prostaat voor het eerste consult leidt bij mannen met een PSA < 7 tot een fors aantal niet-geïndiceerde MRI’s. Bij een PSA > 7 is op basis van de RPCRC-3/4 de MRI bijna altijd gerechtvaardigd.
Procedure Valuation: How a Code Becomes an RVU and a Review of the Current Literature
Authors: Quinton Brooke A. , Quereshy Humzah A. , Cleveland Chelsea , Hayden Jamil , Shah Jay R. 
Published: May 2024

Abstract
Purpose of Review
The goal of this review is to describe the complex process by which a procedure code is assigned value using relative value units (RVUs) and discuss current research that assesses the objectivity and equity of the process.

Recent Findings
While research on this topic is somewhat limited, the authors of a majority of studies call for revaluation of common codes within their surgical specialty due to misvaluation when comparing current RVU scales with national procedure time data. In addition, several studies report that the current system does not adequately reflect patient-based factors that influence physician workload during a case. Finally, certain small subspecialties and pediatric subspecialties in surgical fields are particularly vulnerable to misvaluation.

Summary
Procedure valuation is critically important for surgeons to understand to ensure advocacy for their field and their patients. Continued research using large, national datasets will provide evidence for needed improvements in objectivity in this process and increased surgeon participation in this committee-based decision is imperative for equitable change.
Incorporating physiological knowledge into correlative species distribution models minimizes bias introduced by the choice of calibration area
Authors: Zhang Zhixin , Zhou Jinxin , García Molinos Jorge , Mammola Stefano , Bede-Fazekas Ákos , Feng Xiao , Kitazawa Daisuke , Assis Jorge , Qiu Tianlong , Lin Qiang 
Published: May 2024

AbstractCorrelative species distribution models (SDMs) are important tools to estimate species’ geographic distribution across space and time, but their reliability heavily relies on the availability and quality of occurrence data. Estimations can be biased when occurrences do not fully represent the environmental requirement of a species. We tested to what extent species’ physiological knowledge might influence SDM estimations. Focusing on the Japanese sea cucumber Apostichopus japonicus within the coastal ocean of East Asia, we compiled a comprehensive dataset of occurrence records. We then explored the importance of incorporating physiological knowledge into SDMs by calibrating two types of correlative SDMs: a naïve model that solely depends on environmental correlates, and a physiologically informed model that further incorporates physiological information as priors. We further tested the models’ sensitivity to calibration area choices by fitting them with different buffered areas around known presences. Compared with naïve models, the physiologically informed models successfully captured the negative influence of high temperature on A. japonicus and were less sensitive to the choice of calibration area. The naïve models resulted in more optimistic prediction of the changes of potential distributions under climate change (i.e., larger range expansion and less contraction) than the physiologically informed models. Our findings highlight benefits from incorporating physiological information into correlative SDMs, namely mitigating the uncertainties associated with the choice of calibration area. Given these promising features, we encourage future SDM studies to consider species physiological information where available.
Lie Symmetry Analysis, Power Series Solutions and Conservation Laws of (2+1)-Dimensional Time Fractional Modified Bogoyavlenskii–Schiff Equations
Authors: Yu Jicheng , Feng Yuqiang 
Published: May 2024

Abstract
In this paper, Lie symmetry analysis method is applied to the (2+1)-dimensional time fractional modified Bogoyavlenskii–Schiff equations, which is an important model in physics. The one-dimensional optimal system composed by the obtained Lie symmetries is utilized to reduce the system of (2+1)-dimensional fractional partial differential equations with Riemann–Liouville fractional derivative to the system of (1+1)-dimensional fractional partial differential equations with Erdélyi–Kober fractional derivative. Then the power series method is applied to derive explicit power series solutions for the reduced system. In addition, the new conservation theorem and the generalization of Noether operators are developed to construct the conservation laws for the equations studied.
Grazing Management Plan Adoption and Objective Prioritization in U.S. Cow-Calf and Stocker Operations
Authors: Tang Minfeng , Aherin Cassandra Kniebel , Pendell Dustin L. , Johnson Myriah D. , McDonald Ashley , Lancaster Phillip A. 
Published: May 2024

AbstractThis study examines the grazing management plans (GMPs) adoption and prioritization of environmental and economic objectives among U.S. cow-calf and stocker operations, utilizing 2020–2021 survey data and logistic regression analysis. Findings reveal regional adoption differences, with higher rates in the Midwest. Operations with succession plans, larger grazing lands, and stocker activities are more likely to adopt GMPs. Operations with more privately owned land and smaller herd sizes prefer environmental goals, while those with less grazing land prioritize economic outcomes due to resource concerns. The study provides insights for policies promoting GMP adoption and sustainability in the U.S. beef sector.
An improved Baldwin–Lomax algebraic wall model for high-speed canonical turbulent boundary layers using established scalings
Authors: Chen Xianliang , Gan Jianping , Fu Lin 
Published: May 2024

In this work, we employ well-established relations for compressible turbulent mean flows, including the velocity transformation and algebraic temperature–velocity (TV) relation, to systematically improve the algebraic Baldwin–Lomax (BL) wall model for high-speed zero-pressure-gradient air boundary layers. Any new functions or coefficients fitted by ourselves are avoided. Twelve published direct numerical simulation (DNS) datasets are employed for a priori inspiration and a posteriori examination, with Mach numbers up to 14 under adiabatic, cold and heated walls. The baseline BL model is the widely used one with semilocal scalings. Three targeted modifications are made. First, we employ a total-stress-based transformation (Griffin et al., Proc. Natl Acad. Sci. USA, vol. 118, issue 34, 2021, e2111144118) to the inner-layer eddy viscosity for improved scaling up to the logarithmic region. Second, we utilize the van Driest transformation in the outer layer based on the compressible defect velocity scaling. Third, considering the difficulty in modelling the rapidly varying and singular turbulent Prandtl number near the temperature peak in cold-wall cases, we design a two-layer strategy and use the TV relation to formulate the inner-layer temperature. Numerical results prove that the modifications take effect as designed. The prediction accuracy for mean streamwise velocity is notably improved for diabatic cases, especially in the logarithmic region. Moreover, a significant improvement in mean temperature is realized for both adiabatic and diabatic cases. The mean relative errors of temperature to DNS for all cases are down to 0.4 % in the logarithmic wall-normal coordinate and 3.4 % in the outer coordinate, around one-third of those in the baseline model.
Multivariate regularly varying insurance and financial risks in multidimensional risk models
Authors: Cheng Ming , Konstantinides Dimitrios G. , Wang Dingcheng 
Published: May 2024

AbstractMultivariate regular variation is a key concept that has been applied in finance, insurance, and risk management. This paper proposes a new dependence assumption via a framework of multivariate regular variation. Under the condition that financial and insurance risks satisfy our assumption, we conduct asymptotic analyses for multidimensional ruin probabilities in the discrete-time and continuous-time cases. Also, we present a two-dimensional numerical example satisfying our assumption, through which we show the accuracy of the asymptotic result for the discrete-time multidimensional insurance risk model.