bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiovascular profile in ankylosing spondylitis: A systematic review and meta‐analysis
Authors: Mathieu Sylvain , Gossec Laure , Dougados Maxime , Soubrier Martin 
Published: October 2010

AbstractObjectiveRheumatoid arthritis is associated with increased cardiovascular risk. In ankylosing spondylitis (AS), there is a paucity of information concerning this risk. Our objective was to assess the incidence of myocardial infarction (MI) or strokes and the cardiovascular risk profile in AS patients.MethodsWe performed a systematic literature review using PubMed, EMBase, and the Cochrane Library up to August 2009. Incidence of MI or stroke was calculated by metaproportion. For cardiovascular risk factors, differences between AS patients and controls were expressed by standardized mean differences using inverse of variance method.ResultsFor MI, 8 longitudinal studies were included. In controls (n = 82,745), 1,318 MI cases were observed (4.6%; 95% confidence interval [95% CI] 1.2%, 10.0%). In AS patients (n = 3,279), 224 MI cases were reported (incidence 7.4%; 95% CI 5.2%, 10.0%). The increase in MI cases in AS patients was not significant (risk ratio 1.88; 95% CI 0.83, 4.28). For stroke, 7 longitudinal studies reported 327 strokes in AS patients (n = 31,949), which is an incidence of 2.2% (95% CI 1.3%, 3.4%). In controls (n = 7,372), one study reported 170 strokes (2.3%; 95% CI 2.0%, 2.7%). For cardiovascular risk factors, 15 case–control studies and 9 abstracts were included (n = 1,214 for patients and n = 1,000 for controls). AS patients were characterized by a higher weighted mean intima‐media thickness and higher risk of metabolic syndrome. In AS patients, there was a significant decrease in triglycerides, total cholesterol, and high‐density lipoprotein (HDL) cholesterol.ConclusionAS patients appear to be at higher risk of MI, which could be due to low HDL cholesterol levels or to systemic inflammation. Management of cardiovascular risk factors and control of systemic inflammation should be taken into account in AS.
Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice
Authors: Soffritti Morando , Belpoggi Fiorella , Manservigi Marco , Tibaldi Eva , Lauriola Michelina , Falcioni Laura , Bua Luciano 
Published: September 2010

AbstractBackgroundAspartame (APM) is a well‐known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague–Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and that its effects are increased when exposure starts from prenatal life.ObjectiveThe aim of this study is to evaluate the potential of APM to induce carcinogenic effects in mice.MethodsSix groups of 62–122 male and female Swiss mice were treated with APM in feed at doses of 32,000, 16,000, 8,000, 2,000, or 0 ppm from prenatal life (12 days of gestation) until death. At death each animal underwent complete necropsy and all tissues and organs of all animals in the experiment were microscopically examined.ResultsAPM in our experimental conditions induces in males a significant dose‐related increased incidence of hepatocellular carcinomas (P < 0.01), and a significant increase at the dose levels of 32,000 ppm (P < 0.01) and 16,000 ppm (P < 0.05). Moreover, the results show a significant dose‐related increased incidence of alveolar/bronchiolar carcinomas in males (P < 0.05), and a significant increase at 32,000 ppm (P < 0.05).ConclusionsThe results of the present study confirm that APM is a carcinogenic agent in multiple sites in rodents, and that this effect is induced in two species, rats (males and females) and mice (males). No carcinogenic effects were observed in female mice. Am. J. Ind. Med. 53:1197–1206, 2010. © 2010 Wiley‐Liss, Inc.
Nonisothermal crystallization and melting behavior of β‐nucleated isotactic polypropylene and polyamide 66 blends
Authors: Yang Zhugen , Mai Kancheng 
Published: September 2010

AbstractA highly novel nano‐CaCO3 supported β‐nucleating agent was employed to prepare β‐nucleated isotactic polypropylene (iPP) blend with polyamide (PA) 66, β‐nucleated iPP/PA66 blend, as well as its compatibilized version with maleic anhydride grafted PP (PP‐g‐MA), maleic anhydride grafted polyethylene‐octene (POE‐g‐MA), and polyethylene‐vinyl acetate (EVA‐g‐MA), respectively. Nonisothermal crystallization behavior and melting characteristics of β‐nucleated iPP and its blends were investigated by differential scanning calorimeter and wide angle X‐ray diffraction. Experimental results indicated that the crystallization temperature (T) of PP shifts to high temperature in the non‐nucleated PP/PA66 blends because of the α‐nucleating effect of PA66. T of PP and the β‐crystal content (Kβ) in β‐nucleated iPP/PA66 blends not only depended on the PA66 content, but also on the compatibilizer type. Addition of PP‐g‐MA and POE‐g‐MA into β‐nucleated iPP/PA66 blends increased the β‐crystal content; however, EVA‐g‐MA is not benefit for the formation of β‐crystal in the compatibilized β‐nucleated iPP/PA66 blend. It can be relative to the different interfacial interactions between PP and compatibilizers. The nonisothermal crystallization kinetics of PP in the blends was evaluated by Mo's method. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Living AnatoME: Teaching and learning musculoskeletal anatomy through yoga and Pilates
Authors: McCulloch Carrie , Marango Stephanie Pieczenik , Friedman Erica S. , Laitman Jeffrey T. 
Published: October 2010

AbstractLiving AnatoME, a program designed in 2004 by two medical students in conjunction with the Director of Anatomy, teaches musculoskeletal anatomy through yoga and Pilates. Previously offered as an adjunct to the Gross Anatomy course in 2007, Living AnatoME became an official part of the curriculum. Previous research conducted on the program demonstrated its efficacy in providing relaxation and well‐being to students who attended. In 2007, with all 144 gross anatomy students required to participate in a 1.5 hour Living AnatoME session on the upper and lower limbs, the impact of the program on students' comprehension of musculoskeletal anatomy was analyzed through the administration of 25‐question pre‐ and post‐tests, gauging knowledge in the following domains: upper limb, lower limb, muscle function, palpation, attachment/location, clinical correlate, and control (i.e., material not emphasized during the intervention). Analysis of postintervention tests revealed significant improvement in total Living AnatoME scores as well as in the domains of upper limb, muscle function, and palpation, indicating the possible efficacy of Living AnatoME in teaching anatomy. Performance on control questions also improved, although not significantly, which may indicate the role of other variables (e.g., additional study time) in increased performance. Anat Sci Educ. © 2010 American Association of Anatomists.
A Water‐Soluble Conjugated Polymer for Protein Identification and Denaturation Detection
Authors: Xu Qingling , Wu Chunxian , Zhu Chunlei , Duan Xinrui , Liu Libing , Han Yuchun , Wang Yilin , Wang Shu 
Published: September 2010

AbstractRapid and sensitive methods to detect proteins and protein denaturation have become increasingly needful in the field of proteomics, medical diagnostics, and biology. In this paper, we have reported the synthesis of a new cationic water‐soluble conjugated polymer that contains fluorene and diene moieties in the backbone (PFDE) for protein identification by sensing an array of PFDE solutions in different ionic strengths using the linear discriminant analysis technique (LDA). The PFDE can form complexes with proteins by electrostatic and/or hydrophobic interactions and exhibits different fluorescence response. Three main factors contribute to the fluorescence response of PFDE, namely, the net charge density on the protein surface, the hydrophobic nature of the protein, and the metalloprotein characteristics. The denaturation of proteins can also be detected using PFDE as a fluorescent probe. The interactions between PFDE and proteins were also studied by dynamic light scattering (DLS) and isothermal titration microcalorimetry (ITC) techniques. In contrast to other methods based on conjugated polymers, the synthesis of a series of quencher or dye‐labeled acceptors or protein substrates has been avoided in our method, which significantly reduces the cost and the synthetic complexity. Our method provides promising applications on protein identification and denaturation detection in a simple, fast, and label‐free manner based on non‐specific interaction‐induced perturbation of PFDE fluorescence response.
Characterizing and modeling the diversity of cropping situations under climatic constraints in West Africa
Authors: Traoré Seydou B. , Alhassane Agali , Muller Bertrand , Kouressy Mamoutou , Somé Léopold , Sultan Benjamin , Oettli Pascal , Siéné Laopé Ambroise C. , Sangaré Safiatou , Vaksmann Michel , Diop Mbaye , Dingkhun Michael , Baron Christian 
Published: October 2010

AbstractThe Sahel region is known for the high vulnerability of its agriculture to climate variability. Early warning systems that make use of agrometerological forecasts are one of the coping strategies developed by policy makers. However, the predictive quality of the tools and methods used needs improvement. In order to address some of these challenges, we conducted agronomic trials and on‐farm surveys to adapt the SARRAH (Système d'Analyse Régionale des Risques Agroclimatiques, version H) crop simulation model, and also evaluated it in farmers' field conditions. The farmers' practices such as sowing dates and densities, fertilizer use and yields potentials of the millet and sorghum crops were characterized under different climatic conditions. Copyright © 2010 Royal Meteorological Society
Ljungan virus: A commentary on its association with fetal and infant morbidity and mortality in animals and humans
Authors: Krous Henry F. , Langlois Neil E. 
Published: October 2010

AbstractEpidemiologic and experimental data support the notion that Ljungan virus (LV), endemic in some rodent populations in Sweden, Denmark, and the United States, can cause morbidity and mortality in animals and humans. LV infection can cause type I diabetes mellitus, myocarditis, and encephalitis in bank voles and experimental mice, and lemmings. Mouse dams infected with LV experience high rates of stillbirth that may persist across generations, and their fetuses may develop cranial, brain, and limb malformations. In humans, epidemiologic and serologic data suggest that LV infection correlates with intrauterine fetal death, malformations, placental inflammation, myocarditis, encephalitis, and Guillain‐Barré syndrome. The proposed role of LV infection in SIDS is unconvincing. Further research is necessary to clarify the role of LV infection in animal and human disease. Birth Defects Research (Part A), 2010. © 2010 Wiley‐Liss, Inc.
Synthesis of Room‐Temperature Ionic Liquids with the Weakly Coordinating [Al(ORF)4]− Anion (RF=C(H)(CF3)2) and the Determination of Their Principal Physical Properties
Authors: Bulut Safak , Klose Petra , Huang Mian‐Mian , Weingärtner Hermann , Dyson Paul J. , Laurenczy Gábor , Friedrich Christian , Menz Jakob , Kümmerer Klaus , Krossing Ingo 
Published: September 2010

AbstractA large series of ionic liquids (ILs) based on the weakly coordinating alkoxyaluminate [Al(hfip)4]− (hfip: hexafluoroisopropoxy) with classical as well as functionalized cations were prepared, and their principal physical properties determined. Melting points are between 0 ([C4MMIM][Al(hfip)4]) and 69 °C ([C3MPip][Al(hfip)4]); three qualify as room‐temperature ILs (RTILs). Crystal structures for six ILs were determined; their structural parameters and anion–cation contacts are compared here with known ILs, with a special focus on their influence on physical properties. Moreover, the biodegradability of the compounds was investigated by using the closed‐bottle and the manometric respirometry test. Temperature‐dependent viscosities and conductivities were measured between 0 and 80 °C, and described by either the Vogel–Fulcher–Tammann (VFT) or the Arrhenius equations. Moreover, conductivities and viscosities were investigated in the context of the molecular volume, Vm. Physical property–Vm correlations were carried out for various temperatures, and the temperature dependence of the molecular volume was analyzed by using crystal structure data and DFT calculations. The IL ionicity was investigated by Walden plots; according to this analysis, [Al(hfip)4]− ILs may be classified as “very good to good ILs”; while [C2MIM][Al(hfip)4] is a better IL than [C2MIM][NTf2]. The dielectric constants of ten [Al(hfip)4]− ILs were determined, and are unexpectedly high (εr=11.5 to 16.8). This could be rationalized by considering additional calculated dipole moments of the structures frozen in the solid state by DFT. The determination of hydrogen gas solubility in [Al(hfip)4]− RTILs by high‐pressure NMR spectroscopy revealed very high hydrogen solubilities at 25 °C and 1 atm. These results indicate the significant potential of this class of ILs in manifold applications.
Vapochromic and Mechanochromic Tetrahedral Gold(I) Complexes Based on the 1,2‐Bis(diphenylphosphino)benzene Ligand
Authors: Osawa Masahisa , Kawata Isao , Igawa Satoshi , Hoshino Mikio , Fukunaga Takeo , Hashizume Daisuke 
Published: September 2010

AbstractTetrahedral gold(I) complexes containing the diphosphane ligand (dppb=1,2‐bis(diphenylphosphino)benzene), [Au(dppb)2]X [X=Cl (1), Br (2), I (3), NO3 (4), BF4 (5), PF6 (6), B(C6H4F‐4)4 (7)], and the ethanol and methanol adducts of complex 4, 8, and 9, were prepared to analyze their unique photophysical properties. These complexes are classified into two categories on the basis of their crystal structures. In Category I, the complexes (1–5) have relatively‐small counter anions and two dppb ligands are symmetrically coordinated to the central AuI atom, and display an intense blue phosphorescence. Alternatively, the complexes (6–9) in Category II have large counter anions and two dppb ligands asymmetrically coordinated to AuI atom, and display a yellow or yellow orange phosphorescence. The difference in the phosphorescence color of the complexes between the Category I and II is ascribed to the change in the structure of the cationic moiety in the complex. According to DFT calculations, the symmetry reduction caused by the large counter anion of the complex in Category II gives the destabilization of HOMO (σ*) levels, leading to the red‐shift of the emission peak. We have demonstrated that the symmetry reductions are responsible for the phosphorescence color alteration caused by external stimuli (volatile organic compounds and mechanical grinding).
ChemInform Abstract: Pyrrolizidine Alkaloids from the Roots of Paris verticillata.
Authors: Kim Ki Hyun , Lee Kyu Ha , Choi Sang Un , Kim Kyung Ran , Lee Kang Ro 
Published: September 2010

AbstractThe three new pyrrolizidine alkaloids verticillatins A (I), B (II), and C (III) are isolated from the roots of Paris verticillata (Liliaceae) together with seven known alkaloids.
Product Design of Plastic Materials for the Detergent Industry
Authors: Rähse W. 
Published: October 2010

AbstractWasserlösliche Polymere werden in der Waschmittelindustrie sowohl in den Formulierungen zur Verbesserung des Waschergebnisses als auch als Folien für die Verpackung flüssiger Waschmittelportionen gebraucht. Unlösliche, thermoplastische Kunststoffe (PE, PP, PET) werden als Verpackungsmaterial für Feststoffe, Pasten, Suspensionen und Flüssigkeiten in Form von kaschiertem Karton, Beuteln, Flaschen, Eimern und Tuben eingesetzt. Die Polymere lassen sich je nach Anwendung maßschneidern. Hierfür stehen nicht nur die Möglichkeiten der Reaktions‐ und Synthesetechnik zur Verfügung, sondern es gelingt auch über den Zusatz von Additiven die geforderten physikalischen, technischen und optischen Eigenschaften, z. B. Farbe und Alterungsbeständigkeit, einzustellen. Die im Extruder aufgeschmolzenen Thermoplasten lassen sich beliebig formen. Die Verpackungen sollen nicht nur in Form und Funktion, sondern auch in der gesamten Ästhetik überzeugen und markentypisch gestaltet sein. Das Produktdesign ist die Summe dieser Parameter.
Substitution of Scarce Metals – A Way out of Resource Scarcities?
Authors: Ziemann S. , Schebek L. 
Published: October 2010

AbstractViele technische Anwendungen benötigen eine wachsende Zahl von Metallen, die meist zwar nur in äußerst geringen Mengen in den Produkten enthalten, aber durch ihre einzigartigen Werkstoffeigenschaften nahezu unentbehrlich sind. Eine nachhaltige Bewirtschaftung mineralischer Rohstoffe ist unerlässlich um die Rohstoffversorgung bedeutender Schlüsseltechnologien zu gewährleisten. Die Substitution knapper Metalle wird dabei als eine Erfolg versprechende Strategie angesehen.
Potential of Construction and Demolition Waste as Raw Material
Authors: Müller A. , Schnell A. , Rübner K. 
Published: October 2010

AbstractDie Ressourcenverknappung und steigende Preise rücken nachhaltiges Wirtschaften und die Wiederverwertung von Abfällen in den Blickpunkt der Forschung. Bauabfälle sind in Deutschland – mit 72,4 Mio. t im Jahr 2004 – der größte Abfallstrom. Es wird ein Überblick über den Stand der Technik zur Aufarbeitung und Verwertung von Bauabfällen gegeben und die Anforderungen an Bauabfälle, die als Sekundärrohstoff eingesetzt werden sollen, diskutiert. Die Forschung im Baustoffrecycling bezieht sich sowohl auf neue Aufbereitungstechniken als auch auf die Charakterisierung der Recyclingmaterialien sowie auf deren Einfluss auf die Betonqualität. Die Eignung und Verwertung von Bauabfällen als Sekundärrohstoffe für Baustoffe wird anhand ihrer chemischen Zusammensetzungen mit Hilfe von ternären Diagrammen diskutiert.
A Theoretical Study on the Vibrational Spectra and Thermodynamic Properties for the Derivatives of 2,5‐Dipicryl‐1,3,4‐oxadiazole with –NO2, –NH2, –OH and –CH3 Groups
Authors: Wang Guixiang , Gong Xuedong , Liu Yan , Xu Xiaojuan , Xiao Heming 
Published: September 2010

AbstractThe derivatives of 2,5‐dipicryl‐1,3,4‐oxadiazole (DPO) with nitro, amino, hydroxy and methyl groups were optimized to obtain their molecular geometries and electronic structures at the DFT‐B3LYP/6‐31G* level. Their IR spectra were obtained and assigned by vibrational analysis. Compared with the experimental results, all the calculated IR data were found to be reliable. Based on the frequencies scaled by 0.96 and the principle of statistic thermodynamics, the thermodynamic properties were evaluated, which are respectively linearly related with the number of nitro, amino, hydroxy and methyl groups as well as the temperature, obviously showing good group additivity.
Photoinduced Electron Transfer within Porphyrin‐Anthra‐quinone Dyads Connected by Hamilton Hydrogen Bonding
Authors: Zhao Xin , Chen Jinping , Zeng Yi , Li Yingying , Han Yongbin , Li Yi 
Published: September 2010

AbstractPorphyrin‐ or zinc‐porphyrin‐cyanuric acid conjugants (TPP‐CA or ZnTPP‐CA) and anthraquinone connected with the known "Hamilton receptor" (AQ‐H) were synthesized. The supramolecular dyads constructed via the AQ‐H and TPP‐CA/ZnTPP‐CA exhibit six hydrogen bonds, which provide the association constant KAPP approximately (2.8±0.3)×103 mol−1·L in toluene. Selective excitation of the porphyrin/zinc porphyrin chromophores results in an electron transfer between TPP‐CA/ZnTPP‐CA and AQ‐H within the supramolecular assemblies, leading to an efficient quenching of the TPP‐CA/ZnTPP‐CA fluorescence. The singlet electron transfer from porphyrin/ zinc‐porphyrin to anthraquinone proceeds mainly via a 'through space' mechanism with efficiencies of 43%, 58%, and rate constants of 7.6×107, 7.0×108 s−1, respectively.
Study on the Reactions of 3‐Bromo‐4‐ethoxy‐1,1,1‐trifluoro‐ 3‐buten‐2‐one with Benzenethiols Promoted by InCl3·4H2O
Authors: Zhao Jingwei , Song Tao , Jiang Huiling , Xu Liangzhong , Zhu Shizheng 
Published: September 2010

AbstractIn the presence of InCl3·4H2O, the reaction of 3‐bromo‐4‐ethoxy‐1,1,1‐trifluoro‐3‐buten‐2‐one 2 with a series of benzenethiols proceeds readily and gave both the addition‐elimination product 3‐bromo‐1,1,1‐trifluoro‐4‐thiophenyl‐but‐3‐en‐2‐one and substitution product 1,1,1‐trifluoro‐3,4‐bis‐thiophenyl‐but‐3‐en‐2‐one. The reactivity of benzenethiols is discussed in terms of their substituted group.
Synthesis of Oxindoles via Direct Photolysis of N‐(2‐Bromoaryl)alkanamides
Authors: Cao Lidong , Li Chaozhong 
Published: September 2010

AbstractThe direct photolysis of N‐(2‐bromoaryl)alkanamides in refluxing acetonitrile with NaHCO3 as the base afforded the corresponding oxindoles in moderate to high yields under transition‐metal‐free and radical‐initiator‐free conditions.
Identification of Angiotensin I‐Converting Enzyme Inhibitors in Peptides Mixture of Hydrolyzed Red Deer Plasma with Proteomic Approach
Authors: Liu Xiaoyan , Song Chunxia , Chen Rui , Jiang Xinning , Jin Yan , Zou Hanfa 
Published: September 2010

AbstractProteomics is a rapidly emerging set of key technologies that are of major importance for proteins and drug development process, especially when mass spectrometry (MS) is being used for high‐throughput characterization and identification of proteins. Since the safer and healthier angiotensin I‐converting enzyme (ACE) inhibitors are extremely concerned, many research groups have combed for novel ACE inhibitors from food components by different approaches. Here, shotgun proteomics technology aided with structure‐activity analysis was applied to screen ACE inhibitory peptides from hydrolyzed red deer plasma. The peptides were analysed by mass spectrometry after primary separation with Sephadex G‐25 chromatography. 36 peptides were identified by searching red deer database and 165 peptide sequences derived were identified in mammalian database. Amino acid sequences of peptide and bioactivity relationship have been developed as a faster and useful way to predict and screen new inhibitors. Depending on the relationship of peptide structure and ACE inhibitory activity, a nonapeptide, VYNEGLPAP, was predicted with ACE inhibitory activity. The activity was verified by synthesized VYNEGLPAP and the 50% inhibition concentration (IC50) was 3.1 µmol·L−1. VYNEGLPAP had good thermal stability, pH stability and strong enzyme‐resistant properties against gastrointestinal protease. Kinetic experiments demonstrated that inhibitory kinetic mechanism of this peptide was competitive. This study demonstrated the possibility of screening bioactive peptides from protein hydrolysates mixture based on shotgun proteomics technology, which will provide a potential convenient method to screening bioactive peptides from protein source.
Application of Tandem Mass Spectra for the Peaks of Isotope Pattern in the Elemental Composition Assignment of Product Ions
Authors: Leng Jiapeng , Wang Haoyang , Zhang Li , Zhang Jing , Guo Yinlong 
Published: September 2010

AbstractFor an ion of known formula, there are some ambiguous formulas with respect to its product ions in tandem mass spectrometry in many cases. Researchers determined them mainly by high resolution mass spectrometer combing database searching. Here, we presented an innovative method to enhance the assignment possibility of the elemental composition of the product ion by exploiting the tandem mass spectra of isotopic peaks from the precursor ion such as [M+H+1]+, [M+H+2]+ and [M+H+3]+. This approach involved a process of excluding low match formulas for product ion stepwise until the final formula with the highest match. It also facilitated the deduction of the fragmentation pathway for the precursor ion in tandem mass spectrometry. The isotopic proportions of product ions possessed a good repeatability. Additionally, this method could be performed fast and conveniently on variety of instruments, which offers an alternative determination tool for the elemental composition of product ion in tandem mass spectrometry.