bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV
Authors: Akay-Espinoza Cagla , Newton Sarah E.B. , Dombroski Beth A. , Kallianpur Asha , Bharti Ajay , Franklin Donald R. , Schellenberg Gerard D. , Heaton Robert K. , Grant Igor , Ellis Ronald J. , Letendre Scott L. , Jordan-Sciutto Kelly L. 
Published: May 2024

Abstract
Based on emerging evidence on the role for specific single-nucleotide variants (SNVs) in EIF2AK3 encoding the integrated stress response kinase PERK, in neurodegeneration, we assessed the association of EIF2AK3 SNVs with neurocognitive performance in people with HIV (PWH) using a candidate gene approach. This retrospective study included the CHARTER cohort participants, excluding those with severe neuropsychiatric comorbidities. Genome-wide data previously obtained for 1047 participants and targeted sequencing of 992 participants with available genomic DNA were utilized to interrogate the association of three noncoding and three coding EIF2AK3 SNVs with the continuous global deficit score (GDS) and global neurocognitive impairment (NCI; GDS ≥ 0.5) using univariable and multivariable methods, with demographic, disease-associated, and treatment characteristics as covariates. The cohort characteristics were as follows: median age, 43.1 years; females, 22.8%; European ancestry, 41%; median CD4 + T cell counts, 175/µL (nadir) and 428/µL (current). At first assessment, 70.5% used ART and 68.3% of these had plasma HIV RNA levels ≤ 200 copies/mL. All three noncoding EIF2AK3 SNVs were associated with GDS and NCI (all p < 0.05). Additionally, 30.9%, 30.9%, and 41.2% of participants had at least one risk allele for the coding SNVs rs1805165 (G), rs867529 (G), and rs13045 (A), respectively. Homozygosity for all three coding SNVs was associated with significantly worse GDS (p < 0.001) and more NCI (p < 0.001). By multivariable analysis, the rs13045 A risk allele, current ART use, and Beck Depression Inventory-II value > 13 were independently associated with GDS and NCI (p < 0.001) whereas the other two coding SNVs did not significantly correlate with GDS or NCI after including rs13045 in the model. The coding EIF2AK3 SNVs were associated with worse performance in executive functioning, motor functioning, learning, and verbal fluency. Coding and non-coding SNVs of EIF2AK3 were associated with global NC and domain-specific performance. The effects were small-to-medium in size but present in multivariable analyses, raising the possibility of specific SNVs in EIF2AK3 as an important component of genetic vulnerability to neurocognitive complications in PWH.

Graphical Abstract
Taxonomic Status of Diplectanum robustitubum Wu & Li, 2003 (Monogenoidea: Diplectanidae) from the Purple-Spotted Bigeye Priacanthus tayenus (Priacanthidae) and the Description of Platycephalotrema parile n. sp. (Monogenoidea: Dactylogyridae) from the Bartail Flathead Platycephalus indicus (Platycephalidae), in the Arabian Gulf
Authors: Kritsky Delane C. , Al-Darwesh Ali Adnan , Ali Atheer H. 
Published: May 2024

Abstract
Purple-spotted bigeyes Priacanthus tayenus Richardson (Priacanthidae) and bartail flathead Platycephalus indicus (Linnaeus) (Platycephalidae) were collected from the Arabian Gulf and examined for species of Monogenoidea (Polyonchoinea) from February to December 2020. Diplectanum robustitubum Wu & Li, 2003 and an undescribed species of Platycephalotrema Kritsky & Nitta, 2019 were recovered from the gill lamellae of these hosts, respectively. Diplectanum robustitubum from Iraq was redescribed and transferred to Oliveriplectanum Domingues & Boeger, 2008 (Diplectanidae) as Oliveriplectanum robustitubum (Wu & Li, 2003) n. comb. Platycephalotrema parile n. sp. (Dactylogyridae) from Iraq and Kuwait was described and differentiated from the similar species, Haliotrema indicum Tripathi, 1959, Platycephalotrema ogawai Kritsky & Nitta, 2019, and Platycephalotrema platycephali (Yin & Sproston, 1948) Kritsky & Nitta, 2019, based primarily on the comparative morphologies of the vaginal sclerites. Haliotrema indicum was transferred to Platycephalotrema as Platycephalotrema indicum (Tripathi, 1959) n. comb. and Haliotrema swatowense Yao, Wang, Xia, & Chen, 1998 was considered a junior subjective synonym of P. indicum. The finding of O. robustitubum in the Arabian Gulf represents a new geographic record for the species.

Background
The present paper represents the third installment concerning the monogenoids collected during surveys to explore their diversity on the marine and freshwater fishes of Iraq. Previous installments on the monogenoids emanating from the surveys included the dactylogyrid and gyrodactylid species parasitizing mugilid fishes.

Purpose
The purpose of this paper is to further document the diversity of monogenoids infecting the fishes of Iraq.

Methods
Marine fishes were necropsied for parasites, and standard procedures for collecting, mounting, drawing, and measuring of monogenoids were employed.

Results
Oliveriplectanum robustitubum n. comb. (Diplectanidae) and Platycephalotrema parile n. sp. (Dactylogyridae) were collected. The occurrence of O. robustitubum in the Arabian Gulf represented a new locality record for the species.

Conclusion
The recorded presence of O. robustitubum and P. parile n. sp. suggests that the diversity of monogenoids in Iraq is under estimated in the literature.
Patient Satisfaction and Experience with Same-Day Discharge After Laparoscopic Roux-en-Y Gastric Bypass: A Mixed-Methods study
Authors: Kleipool Suzanne C. , Willinge Gijs J. A. , Mathijssen Elke G. E. , Romijnders Kim A. G. J. , de Castro Steve M. M. , Marsman Hendrik A. , van Rutte Pim W. J. , van Veen Ruben N. 
Published: May 2024

Abstract
Introduction
Same-day discharge (SDD) after laparoscopic Roux-en-Y gastric bypass (RYGB) is a safe and effective healthcare pathway. However, there is limited understanding of the patient perspective on SDD. The aim of this study was to explore patient satisfaction and experience with SDD after RYGB.

Methods
A mixed-methods study with a concurrent design was conducted in a Dutch teaching hospital, using questionnaires and interviews. Patients who underwent RYGB and were discharged on the day of the surgery completed four questionnaires of the BODY-Q (satisfaction with the surgeon, satisfaction with the medical team, satisfaction with the office staff, and satisfaction with information provision) ± 4 months postoperative. The results of the questionnaires were compared with pre-existing data from a cohort of patients who stayed overnight after surgery (i.e., control group). A subset of patients was individually interviewed for an in-depth understanding of the patient perspective on SDD.

Results
In the questionnaires, median scores for the control group (n = 158) versus the present group of patients (n = 51) were as follows: 92/100 vs. 92/100 (p = 0.331) for the surgeon, 100/100 vs. 92/100 (p = 0.775) for the medical team, 100/100 vs. 100/100 (p = 0.616) for the office staff, and 90/100 vs. 73/100 (p = 0.015) for information provision. Interviews with 14 patients revealed seven themes, describing high satisfaction, along with several points of interest.

Conclusions
Patient satisfaction with SDD after RYGB is high, although information provision regarding the day of surgery could be improved. However, not every medically eligible patient might be suitable for this healthcare pathway, as responsibilities are shifted.

Graphical Abstract
Transplantation of Wnt5a-modified Bone Marrow Mesenchymal Stem Cells Promotes Recovery After Spinal Cord Injury via the PI3K/AKT Pathway
Authors: Yang Haimei , Liang Chaolun , Luo Junhua , Liu Xiuzhen , Wang Wanshun , Zheng Kunrui , Luo Dan , Hou Yu , Guo Da , Lin Dingkun , Zheng Xiasheng , Li Xing 
Published: May 2024

AbstractSpinal cord injury (SCI) is a severe neurological condition that can lead to paralysis or even death. This study explored the potential benefits of bone marrow mesenchymal stem cell (BMSC) transplantation for repairing SCI. BMSCs also differentiate into astrocytes within damaged spinal cord tissues hindering the cell transplantation efficacy, therefore it is crucial to enhance their neuronal differentiation rate to facilitate spinal cord repair. Wnt5a, an upstream protein in the non-classical Wnt signaling pathway, has been implicated in stem cell migration, differentiation, and neurite formation but its role in the neuronal differentiation of BMSCs remains unclear. Thus, this study investigated the role and underlying mechanisms of Wnt5a in promoting neuronal differentiation of BMSCs both in vivo and in vitro. Wnt5a enhanced neuronal differentiation of BMSCs in vitro while reducing astrocyte differentiation. Additionally, high-throughput RNA sequencing revealed a correlation between Wnt5a and phosphoinositide 3-kinase (PI3K)/protein kinase B(AKT) signaling, which was confirmed by the use of the PI3K inhibitor LY294002 to reverse the effects of Wnt5a on BMSC neuronal differentiation. Furthermore, transplantation of Wnt5a-modified BMSCs into SCI rats effectively improved the histomorphology (Hematoxylin and eosin [H&E], Nissl and Luxol Fast Blue [LFB] staining), motor function scores (Footprint test and Basso-Beattie-Bresnahan [BBB]scores)and promoted neuron production, axonal formation, and remodeling of myelin sheaths (microtubule associated protein-2 [MAP-2], growth-associated protein 43 [GAP43], myelin basic protein [MBP]), while reducing astrocyte production (glial fibrillary acidic protein [GFAP]). Therefore, targeting the Wnt5a/PI3K/AKT pathway could enhance BMSC transplantation for SCI treatment.
Ruxolitinib in steroid-refractory acute graft-vs-host disease: Japanese subgroup analysis of the randomized REACH2 trial
Authors: Teshima Takanori , Onishi Yasushi , Kato Koji , Taniguchi Shuichi , Miyamura Koichi , Fukushima Kentaro , Kato Jun , Ishikawa Takayuki , Doki Noriko , Nakamae Hirohisa , Maeda Yoshinobu , Inamoto Yoshihiro , Okada Masaya , Maki Akio , Shimada Fumika , Tajima Takeshi , Wroclawska Monika , Zeiser Robert , Onizuka Makoto 
Published: May 2024

AbstractAcute graft-versus-host disease (aGvHD) is a major complication after allogeneic hematopoietic stem cell transplantation in Japan and other countries. Nearly one-third of patients do not respond to standard systemic steroid therapy and no standard second-line treatment has been established in Japan. We report efficacy and safety findings of ruxolitinib versus best available therapy (BAT) from a subgroup analysis of the international, phase 3 REACH2 study in Japanese patients with steroid-refractory aGvHD. The primary endpoint was overall response rate (ORR) at day 28. Overall, 9 patients received ruxolitinib and 21 received BAT. The ORR at day 28 (88.9% vs 52.4%) and durable ORR at day 56 (66.7% vs 28.6%) were higher with ruxolitinib versus BAT. The estimated cumulative incidence of loss of response at 6 months was 12.5% with ruxolitinib and 18.2% with BAT. The median failure-free survival was longer with ruxolitinib versus BAT (2.73 vs 1.25 months). The most common adverse events up to day 28 in the ruxolitinib and BAT groups were anemia (55.6% vs 19.0%) and thrombocytopenia (44.4% vs 4.8%, respectively). Ruxolitinib showed better efficacy outcomes and a consistent safety profile compared with BAT in the Japanese subgroup, and the findings were consistent with overall study results.
Advancing Aquatic Food Safety Detection Using Highly Sensitive Graphene Oxide and Reduced Graphene Oxide (GO/r-GO) Fluorescent Sensors
Authors: Chen Mei-Xi , Cheng Jun-Hu , Ma Ji , Sun Da-Wen 
Published: May 2024

AbstractWith the increasing demand for aquatic products, the requirement for the safety detection of aquatic products is also increasing. In the past decade, graphene oxide (GO) and reduced graphene oxide (r-GO) have become hot topics in many fields due to their special physical and chemical properties. With their excellent conductivity, a variety of electrochemical sensors have been developed in the fields of biology, food and chemistry. However, the unique optical properties of GO/r-GO have not yet been widely utilized. With the deepening of research, the fluorescence quenching performance of GO/r-GO has been proven to have excellent potential for building fluorescent sensors, and GO/r-GO fluorescent sensors have thus become an inevitable trend in sensor development. This review summarizes the main preparation methods of GO/r-GO and the principles of GO/r-GO fluorescent sensors comprehensively. Additionally, recent advances in utilizing GO/r-GO fluorescent sensors to detect aquatic food are discussed, including the application for the detection of harmful chemicals, microorganisms, and endogenous substances in aquatic products, such as pesticides, antibiotics and heavy metals. It is hoped that this review will help accelerate the progress in the field of analysis, and promote the establishment of an aquatic food supervision system.
The impact of resilience acquisition on students transitioning to university during covid-19: a follow up study with Myanmar students
Authors: Gomersall Steve , Floyd Alan 
Published: May 2024

AbstractIn our previous study (Gomersall & Floyd, in Asia Pacific Education Review 24:447–459, 2022), we reported that a group of Myanmar students, who studied online for their high school qualifications during COVID-19, reported drawing on a range of factors to enable them to overcome the adversity and continue their education. Moreover, they claimed that they had benefited from the online experience and were ready to progress to university. This study returns one year later to interview some of the original participants to see if their perceptions became reality. In addition, a group of students from the 2020 cohort are also interviewed so that a comparison can be made between the last group of students who studied ‘normally’ before COVID-19, and those who experienced online learning for the first time. This study addresses a gap in the literature by examining student perspectives of the ways in which they thrived as a result of digitally enhanced learning. We conclude that learning online enabled students to develop personally, enhance their digital skills, and acquire skills and knowledge that could be utilised again in the future. Moreover, those who studied online in both high school and university found the process of commencing online studies at university easier, which supports the tentative conclusion that even in low resource settings, it would be beneficial for schools to explore integrating more digital skills into the classroom.
Rare origin of the sinoatrial node artery: an anatomic report and a brief review of the literature
Authors: Pinto Filipe F. , Madeira M. Dulce , Pereira Pedro A. 
Published: May 2024

Abstract
Several studies reported anatomical variations in the sinoatrial node artery (SANa). Here, we report a rare variation in the origin of the SANa on a human adult male cadaver. During dissection, we identified the SANa originating from a large atrial branch of the right coronary artery (RCA). This branch originates at the level of the inferior border of the heart and courses upwards. The initial part of this vessel is tortuous, and then it follows a straight path parallel to the RCA along the anterior surface of the right atrium. After this part, the artery curves posteriorly and to the left until it reaches the lower border of the right auricle, where it closely approaches the RCA. Finally, the artery runs posteriorly and to the right to follow a course along the medial wall of the right auricle and right atrium to reach a location close to the region of the junction of the superior vena cava and right atrium, where it follows its path buried in the myocardium. After perforating the myocardium, this vessel gives rise to branches that are distributed to both atria in addition to the SANa. The SANa runs to the sinoatrial node in a precaval (anterior to the superior vena cava) course. We also tried to characterize the vessels radiologically. The knowledge of the anatomical variations of the SANa is of the utmost importance for cardiologists and heart surgeons to better understand cardiac disease and accurately plan and execute cardiac interventions and surgical procedures.
Gap solitons in optical fibers with the concatenation model
Authors: Alngar Mohamed E. M. , Shohib Reham. M. A. , Biswas Anjan , Yildirim Yakup , Moshokoa Seithuti P. , Dakova Anelia , Alshomrani Ali Saleh 
Published: May 2024

AbstractThis paper recovers gap solitons from Bragg gratings of the concatenation model. The new mapping method recovers a full spectrum of optical solitons. The parameter constraints for the existence of such solitons are enumerated.
Insights from elite soccer players: understanding the downward spiral and the complex dynamics of crises
Authors: Jekauc Darko , Vrancic Damir , Fritsch Julian 
Published: May 2024

AbstractThis study focused on identifying the factors that lead to prolonged crises in soccer teams and how players view the development of these crises. A qualitative analysis of interviews with six current and three former professional soccer players revealed that the failure to meet team expectations is often the starting point of crises, which can impact both individual and team levels. The issues at the individual level include anxiety, pressure, lack of self-confidence, somatic manifestations, negative body language, loss of motivation, rumination, and self-focus. At the team level, conflicts arise, the team atmosphere deteriorates, which is reflected in impaired communication and lack of cohesion. During soccer matches, on-field behavior frequently evolves into a more defensive mindset and a desire to avoid mistakes and responsibility, resulting in lower team performance. Poor results usually ensue, perpetuating and even intensifying the crisis process which players refer to as a vicious circle, negative spiral, or vortex. Societal factors such as media landscape, coronavirus disease 2019 (COVID-19) pandemic, club structures, or fans, and individual factors such as crisis experiences, players’ resilience, family cohesion, or support from friends affect the development of crises. The study’s insights illustrate the negative impacts of pressure on the team’s emotional state and social interaction, leading to a downward spiral, and thus, reinforcing the crisis process. The study concludes that crisis management training and support should focus on managing expectations, promoting positive affective states, and supporting healthy motivation among team members, and should expand coaches’ crisis competency training.
Empathy for wildlife: The importance of the individual
Authors: Smith Pauline , Mann Janet , Marsh Abigail 
Published: May 2024

AbstractBecause climate change and the biodiversity crisis are driven by human actions, determining psychological mechanisms underpinning support for environmental action is an urgent priority. Here, we experimentally tested for mechanisms promoting conservation-related motivation and behavior toward a flagship species, wild Tamanend's bottlenose dolphins. Following evidence that empathy increases prosocial motivations and behavior, and that the ability to identify individual humans promotes empathy, we tested whether this relationship applied to the ability to identify individual dolphins. Participants identified dolphins from their dorsal fins at above chance levels, and better individuation correlated with higher empathy for dolphins and higher willingness to pledge environmental behaviors. Pairing a narrative with an image of an injured dolphin leads to higher donations relative to a narrative alone. Our novel finding that the ability to individually identify dolphins relates to empathy and conservation-related behavior suggests pathways for strengthening environmental attitudes and behavior.
Uplifting local ecological knowledge as part of adaptation pathways to wildfire risk reduction: A case study in Montseny, Catalonia (Spain)
Authors: Uyttewaal Kathleen , Stoof Cathelijne R. , Canaleta Guillem , Cifre-Sabater Maria , Langer E. R. , Ludwig Fulco , Kroeze Carolien , Moran Pepa , Ottolini Isabeau , Prat-Guitart Núria 
Published: May 2024

AbstractLiving with wildfires in an era of climate change requires adaptation and weaving together many forms of knowledge. Empirical evidence of knowledge co-production in wildfire management is lacking in Mediterranean European areas. We explored how local ecological knowledge can be leveraged to reduce wildfire risk through an adaptation pathways process in the Montseny massif and wider Tordera River watershed of Catalonia, Spain: an area stewarded through forestry and agriculture, tourism, nature conservation, and fire management. We combined different methods (e.g., a timeline and Three Horizons framework) throughout three workshops with agents of change to co-create adaptation pathways to reduce wildfire risk, integrating a historical perspective of the landscape while envisioning desirable futures. Our results showed that local ecological knowledge and other soft adaptation strategies contribute to innovative sustainable development initiatives that can also mitigate wildfire risk. The adaptation pathways approach holds much potential to inform local policies and support wildfire-based community initiatives in diverse contexts.
AI-Related Risk: An Epistemological Approach
Authors: Zanotti Giacomo , Chiffi Daniele , Schiaffonati Viola 
Published: May 2024

AbstractRisks connected with AI systems have become a recurrent topic in public and academic debates, and the European proposal for the AI Act explicitly adopts a risk-based tiered approach that associates different levels of regulation with different levels of risk. However, a comprehensive and general framework to think about AI-related risk is still lacking. In this work, we aim to provide an epistemological analysis of such risk building upon the existing literature on disaster risk analysis and reduction. We show how a multi-component analysis of risk, that distinguishes between the dimensions of hazard, exposure, and vulnerability, allows us to better understand the sources of AI-related risks and effectively intervene to mitigate them. This multi-component analysis also turns out to be particularly useful in the case of general-purpose and experimental AI systems, for which it is often hard to perform both ex-ante and ex-post risk analyses.
Self-dispersed molybdenum disulfide quantum dot/graphene crumpled ball as efficient high temperature lubricant additive
Authors: Du Guiru , Zhang Yujuan , Fan Shuguang , Song Ningning , Zhang Shengmao , Zhang Pingyu 
Published: May 2024

AbstractInorganic nanoparticles have been proved as powerful lubricant additives at elevated temperature. However, the tribological properties are inevitably impaired due to poor dispersion and insufficient high temperature resistance of organic matter modified nanoparticles. Here, we prepare a self-dispersed molybdenum disulfide quantum dot/graphene crumpled ball (MGCB) comprising molybdenum disulfide quantum dot uniformly interspersed on the wrinkled graphene ball. The crumpled ball composite possesses excellent dispersity in polyalkylene glycol base oil without depending on surface modifiers. Compared with the conventional phosphate esters lubricant, our results indicate MGCB could vastly improve the lubrication performance of polyalkylene glycol with an extremely low concentration (0.05 wt%) at elevated temperature (150 °C), showing a friction reduction of 47% and a wear reduction of 30% compared with the conventional phosphate esters lubricant (tricresyl phosphate, TCP). This is because crumpled ball potentiates synergistic lubrication effect within the boundary lubrication. Overall, we envision our designed self-dispersed MGCB has significant potential in tribological application at elevated temperature.