bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of a cementless onlay short stem reverse shoulder arthroplasty in elderly patients: a comprehensive analysis of clinical and radiological findings
Authors: Claro Rui , Sousa Arnaldo , Silva Eurico , Barros Luís Henrique 
Published: April 2024

Abstract
Objective
The objective of this study was to evaluate clinical and radiological outcomes of a short stem reverse shoulder prosthesis with metaphyseal fixation specifically in older patients.

Methods
All patients, older than 70 years, submitted to a Reverse Shoulder Arthroplasty (RSA) using a cementless onlay short stem (Aequalis Ascend™ Flex Convertible Shoulder System (Stryker®)) from January 2017 to December 2021, with a minimum follow-up of 2 years, were included. Postoperative radiographs were assessed for stem loosening, subsidence, and varus-valgus tilt. Range of motion, visual analogue scale for pain, constant score, complication rate and revision rate were also analysed.

Results
A total of 34 patients with a mean age of 75 years (range 71–83 years) were submitted to a cementless onlay short stem RSA with a Bone Increased Off-Set (BIO-RSA) construct. The mean follow-up period was 61 months (range 54–87). Significant improvements (p < 0.001) were observed for the constant score and range of motion from the preoperative state to final follow-up. One case exhibited a significant varus deviation (> 5˚) during the follow-up period. No case of stem loosening was identified. There was only one case of complication because of post-traumatic dislocation, but the stem didn’t need revision.

Conclusion
Short stem RSA, even in patients older than 70 years, can yield a stable fixation with a good clinical and radiological outcome at short-medium term follow-up.

Level of Evidence
Level III; Retrospective Study
A variety-specific analysis of climate change effects on California winegrapes
Authors: Parker Lauren E. , Zhang Ning , Abatzoglou John T. , Kisekka Isaya , McElrone Andrew J. , Ostoja Steven M. 
Published: April 2024

AbstractCalifornia contains a broad geography over which climate conditions can be suitable for cultivating multiple varieties of winegrapes. However, climate change is projected to make winegrape cultivation more challenging across many of California’s winegrowing regions. In order to understand the potential effects of climate change on winegrapes, this study models variety-specific phenology for six winegrape varieties and quantifies the change in phenology and viticulturally-important agroclimate metrics over 12 of California’s American Viticultural Areas (AVAs) by the mid-21st century. Results show more rapid development for winegrapes with earlier budburst, flowering, veraison, and maturation across all varieties and AVAs. Cabernet Sauvignon shows the greatest change in phenology timing, while Chardonnay shows the least change. Likewise, the West Sonoma Coast AVA shows the greatest average change in phenology timing across varieties and development stages and Lodi AVA shows the least. Projected changes in agroclimatic metrics include an additional month of potentially damaging heat days (above 35 °C) in some AVAs, and decreases in frost days. These results have implications for numerous factors related to viticultural production, including water resources management and crop yield and quality, and underscore the need for California winegrape growers to improve their resilience to climate change by adopting strategies such as increasing soil health and water use efficiency and selecting cultivars suited for future climate conditions. By conducting climate effects analyses at the variety-specific and AVA scale, important information is provided to the winegrowing industry at a resolution that can support decision-making towards resilience.
Improving quality of life after breast cancer: a comparison of two microsurgical treatment options for breast cancer-related lymphedema (BCRL)
Authors: Seidenstuecker Katrin , Fertsch Sonia , Ghazaleh Alina A. , Fabi Adriano , Stoffel Julia , Bukowiecki Julia , Wolter Andreas , Aghlmandi Soheila , Nadella Anshoo , Halbeisen Florian S. , Andree Christoph , Haug Martin D. , Schaefer Dirk J. , Handschin Tristan M. , Kappos Elisabeth A. 
Published: April 2024

Abstract
Purpose
Vascularized lymph node transfer (VLNT) entails the autologous relocation of lymph nodes to a lymphedematous region of the body, whereas lymphaticovenous anastomosis (LVA) creates a direct bypass between the lymphatic and venous system. Both techniques are meant to lastingly bolster the local lymphatic drainage capacity. This study compared safety and effectiveness of VLNT and LVA in patients with chronic breast cancer related lymphedema (BCRL).

Methods
A retrospective cohort study was conducted using data from our encrypted database composed of patients with chronic BCRL who were treated with either VLNT or LVA and had a minimum follow-up of two years. Patient-specific variables analyzed included pre- and postoperative arm circumferences, lymphedema stages and postoperative complications.

Results
A total of 105 patients met the inclusion criteria, of which 96 patients demonstrated a complete follow-up period of two years. The VLNT group displayed larger preoperative circumferential measurements, evident in both in the isolated examination of the affected arm, as well as when adjusted for the contralateral unaffected arm. Significant reduction in arm volume was achieved by both groups. However, VLNT demonstrated superior relative reduction rates than LVA, neutralizing any significant arm size disparities after 24 months. Surgery duration was slightly longer for VLNT than LVA. Postoperative complications, predominantly minor, were exclusively observed in the VLNT group.

Conclusions
Both VLNT and LVA offer significant improvement for patients suffering from chronic BCRL. VLNT shows an even greater potential for improvement in more severe cases of BCRL, but involves a higher risk for (mostly minor) complications.
Observations of golden eagles attacking and consuming wolf pups
Authors: Fernández-Gil Alberto , Carral José M. , Barrientos Luis M. , García Laurentino , Benito Laura , de Gabriel Hernando Miguel 
Published: April 2024

AbstractAlthough lethal interactions between wolves and other apex carnivores have been reported for a handful of species, the killing or consumption of wolves by free-ranging golden eagles has rarely been reported. Here, we present four opportunistic field observations documenting the consumption of a wolf pup by free-ranging golden eagles and predatory behavior of eagles towards wolf pups. Although we could not confirm the killing and consumption of wolves by eagles in a single predatory event, actual predation seems plausible based on our observations. We hypothesize that these intraguild apex predators’ interactions, consisting on a smaller raptor predator attacking or consuming a lager mammal and social predator, are rare events, but provide valuable information on potential relationships across keystone apex predators.
Inconsistencies in rater-based assessments mainly affect borderline candidates: but using simple heuristics might improve pass-fail decisions
Authors: Schauber Stefan K. , Olsen Anne O. , Werner Erik L. , Magelssen Morten 
Published: April 2024

Abstract
Introduction
Research in various areas indicates that expert judgment can be highly inconsistent. However, expert judgment is indispensable in many contexts. In medical education, experts often function as examiners in rater-based assessments. Here, disagreement between examiners can have far-reaching consequences. The literature suggests that inconsistencies in ratings depend on the level of performance a to-be-evaluated candidate shows. This possibility has not been addressed deliberately and with appropriate statistical methods. By adopting the theoretical lens of ecological rationality, we evaluate if easily implementable strategies can enhance decision making in real-world assessment contexts.

Methods
We address two objectives. First, we investigate the dependence of rater-consistency on performance levels. We recorded videos of mock-exams and had examiners (N=10) evaluate four students’ performances and compare inconsistencies in performance ratings between examiner-pairs using a bootstrapping procedure. Our second objective is to provide an approach that aids decision making by implementing simple heuristics.

Results
We found that discrepancies were largely a function of the level of performance the candidates showed. Lower performances were rated more inconsistently than excellent performances. Furthermore, our analyses indicated that the use of simple heuristics might improve decisions in examiner pairs.

Discussion
Inconsistencies in performance judgments continue to be a matter of concern, and we provide empirical evidence for them to be related to candidate performance. We discuss implications for research and the advantages of adopting the perspective of ecological rationality. We point to directions both for further research and for development of assessment practices.
Secretary bird optimization algorithm: a new metaheuristic for solving global optimization problems
Authors: Fu Youfa , Liu Dan , Chen Jiadui , He Ling 
Published: April 2024

AbstractThis study introduces a novel population-based metaheuristic algorithm called secretary bird optimization algorithm (SBOA), inspired by the survival behavior of secretary birds in their natural environment. Survival for secretary birds involves continuous hunting for prey and evading pursuit from predators. This information is crucial for proposing a new metaheuristic algorithm that utilizes the survival abilities of secretary birds to address real-world optimization problems. The algorithm's exploration phase simulates secretary birds hunting snakes, while the exploitation phase models their escape from predators. During this phase, secretary birds observe the environment and choose the most suitable way to reach a secure refuge. These two phases are iteratively repeated, subject to termination criteria, to find the optimal solution to the optimization problem. To validate the performance of SBOA, experiments were conducted to assess convergence speed, convergence behavior, and other relevant aspects. Furthermore, we compared SBOA with 15 advanced algorithms using the CEC-2017 and CEC-2022 benchmark suites. All test results consistently demonstrated the outstanding performance of SBOA in terms of solution quality, convergence speed, and stability. Lastly, SBOA was employed to tackle 12 constrained engineering design problems and perform three-dimensional path planning for Unmanned Aerial Vehicles. The results demonstrate that, compared to contrasted optimizers, the proposed SBOA can find better solutions at a faster pace, showcasing its significant potential in addressing real-world optimization problems.
Robust assessment of life insurance products
Authors: Bernard Carole , De Vecchi Corrado , Vanduffel Steven 
Published: April 2024

AbstractIn this paper we propose a robust assessment for the premium of a standard life insurance contract with respect to the uncertainty on the estimated residual lifetime distribution function. Specifically, we provide a method to derive the range of values that the premium of a given contract can attain when considering all residual lifetime distribution functions that satisfy an $$L^2$$

L
2

distance constraint to a reference distribution function. Furthermore, we show that the $$L^2$$

L
2

distance constraint can be used as flexible starting point to include further information regarding future mortality.
Spatially limited pathogen pollution in an invasive tick and host system
Authors: De Jesus Carrie E. , Harman Madison E. A. , Sutton Amber , Bredin Stephen , Romagosa Christina M. , Wisely Samantha M. 
Published: April 2024

AbstractExpansion of global commerce has facilitated pathogen pollution via the transportation and translocation of invasive species and their associated parasites and pathogens. In Florida, imported cane toads (Rhinella horribilis) were accidentally and intentionally released on multiple occasions. Early populations were found to be infested with the invasive tick, Amblyomma rotundatum, yet it is unknown if these ticks dispersed with their hosts as cane toads spread throughout much of the state. The objectives of our investigation were to (1) determine if there are fewer tick infestations on toads at the periphery than at the core of their distribution as predicted by founder effect events, and (2) identify if ticks were infected with exotic pathogens. We captured toads from 10 populations across Florida. We collected ticks, vent tissue, and tick attachment site tissue from each toad, then tested samples for bacteria in the genus, Rickettsia. We found that 3/10 populations had toads that were infested with A. rotundatum, and infested individuals were in the earliest introduced populations at the core of their distribution. Pathogen testing confirmed Rickettisa bellii in ticks, but not in toad tissues. Haplotype networks could not clearly distinguish if R. bellii in Florida was more closely related to North or South American strains, but host-tick associations suggest that the pathogen was exotic to Florida. Our investigation demonstrated that an invasive species facilitated the introduction of parasites and pathogens into Florida, yet the invasive tick species encountered limitations to dispersal on this host species.
Elongin B promotes breast cancer progression by ubiquitinating tumor suppressor p14/ARF
Authors: Sui Xin-Yi , Ma Xiao-Yan , Hou Yujin , Cao Shuo-Wen , Wang Zhi-Qing , Jia Li-Jun , Fan Lei , Shao Zhi-Ming , Zhang Wen-Juan 
Published: April 2024

Abstract
Elongin B (ELOB), a pivotal element in the ELOB/c-Cullin2/5-SOCS-box E3 ubiquitin-protein ligase complex, plays a significant role in catalyzing the ubiquitination and subsequent degradation of a broad spectrum of target proteins. Notably, it is documented to facilitate these processes. However, the regulatory role of ELOB in breast cancer remains ambiguous. In this study, through bio-informatic analysis of The Cancer Genome Atlas and Fudan University Shanghai Cancer Center database, we demonstrated that ELOB was over-expressed in breast cancer tissues and was related to unfavorable prognosis. Additionally, pathway enrichment analysis illustrated that high expression of ELOB was associated with multiple cancer promoting pathways, like cell cycle, DNA replication, proteasome and PI3K − Akt signaling pathway, indicating ELOB as a potential anticancer target. Then, we confirmed that both in vivo and in vitro, the proliferation of breast cancer cells could be significantly suppressed by the down-regulation of ELOB. Mechanically, immunoprecipitation and in vivo ubiquitination assays prompted that, as the core element of Cullin2-RBX1-ELOB E3 ligase (CRL2) complex, ELOB regulated the ubiquitination and the subsequent degradation of oncoprotein p14/ARF. Moreover, the anticancer efficacy of erasing ELOB could be rescued by simultaneous knockdown of p14/ARF. Finally, through analyzing breast cancer tissue microarrays and western blot of patient samples, we demonstrated that the expression of ELOB in tumor tissues was elevated in compared to adjacent normal tissues. In conclusion, ELOB is identified to be a promising innovative target for the drug development of breast cancer by promoting the ubiquitination and degradation of oncoprotein p14/ARF.

Graphical headlights
ELOB is highly expressed in breast cancer.
High ELOB levels were positively associated with poor prognosis.
ELOB promotes p14/ARF degradation as part of the Cullin2-RBX1-ELOB E3 ligase complex.
ELOB is a promising biomarker for breast cancer.

Graphical Abstract
Robust inversion of 1D magnetotelluric data using the Huber loss function
Authors: Desifatma Elfitra , Djaja I. Gede Putu Fadjar Soerya , Pratomo Prihandhanu Mukti , Supriyadi  , Mustopa Enjang Jaenal , Evita Maria , Djamal Mitra , Srigutomo Wahyu 
Published: April 2024

AbstractIn this study, a robust 1D inversion was performed on magnetotelluric (MT) data by utilizing the Huber loss function to avoid misleading interpretation of results, which is caused by the presence of outliers in the data. The MT method utilizes the ratio between the electric field (E) and the magnetic field (H), which are perpendicular to each other, to obtain impedance values (Z). These values are used to extract subsurface information in the form of electrical resistivity variations with depth. In the study, forward modeling of the 1D MT responses was conducted by recursively calculating Z values. Robust inversion was performed using the Huber loss function as an objective function to minimize the difference between the calculated and observed data. The Huber loss function combines the squared loss and the absolute loss to anticipate the presence of outliers in MT observation data. The robust inversion was performed on synthetic data with additional noise and field data. The inversion process utilized 50 layers with a thickness of 500 m, a hyperparameter $$\varvec{\delta }= 5\times {10}^{-2}$$

δ

=
5
×

10

-
2

, $$\lambda =0.01$$

λ
=
0.01

, and $${\lambda }_{t}=100$$

λ
t

=
100

. The number of iterations used was 500 for inversions that used synthetic data and 3000 for inversions that used field data. The robust inversion scheme using the Huber loss function successfully overcame the presence of outliers and accurately estimated the actual model parameters, both for synthetic data and field data that contained outliers. The misfit was relatively small and close to zero, indicating that the inversion code works well.
Framing adequate digital competence in early childhood education
Authors: Masoumi Davoud , Bourbour Maryam 
Published: April 2024

AbstractDeveloping children’s abilities to act safely, respectfully, and responsibly in digital environments has been an essential component of educational systems for all ages. This study aims to explore what adequate digital competence is in early childhood education and how preschool teachers characterise young children’s adequate digital competence. The research seeks to address these questions by conducting in-depth interviews with 13 preschool teachers at three preschools in Sweden. The collected data were analysed using thematic analysis in accordance with the Grounded Theory perspective.Preschool teachers characterize adequate digital competence in early childhood education as more than just a skillful and safe use of digital technologies. The study reveals seven key themes in which preschool teachers characterise children’s adequate digital competence: (a) to become familiar with digital technologies; (b) to dare try digital technologies; (c) to use digital technologies; (d) to have a critical approach toward digital technologies; (e) to have ethical media competence, which includes moral, formal, and legal responsibilities; (f) to have problem-solving skills; (g) and to be producer, not just a consumer of digital technologies. By framing and exemplifying children’s adequate digital competence, the findings of this study offer a potential framework for preschools and preschool teachers to foster children’s digital competences at an appropriate level.
Is Green Transition in Europe Fostered by Energy and Environmental Efficiency Feedback Loops? The Role of Eco-Innovation, Renewable Energy and Green Taxation
Authors: Chatzistamoulou Nikos , Koundouri Phoebe 
Published: April 2024

AbstractGreen transition is in the core of the European policy agenda to achieve the ambitious goal of climate neutrality following the launch of the European Green Deal. The cornerstone of the new growth strategy of Europe is resource efficiency which focuses on shifting to a more sustainable production paradigm by conserving scarce resources and by prioritizing enhanced environmental performance. Scattered efforts to investigate the drivers of resource efficiency measures have shed light on the key drivers, however, those consider resource efficiency measures in isolation neglecting for feedback loops influencing green transition. Therefore, we develop a conceptual framework to study green transition as a system of resource efficiency measures affected by feedback loops, path dependence, green technologies, and green policy tools. We mobilize the analysis by devising a unique balanced panel covering the EU-28 from 2010 through 2019, including policy efforts paving the way for green transition. Econometric results based on a system of fractional probit models, indicate that resource efficiency measures are intertwined via feedback loops, especially in the case of environmental efficiency. Green technologies affect green transition, however, rebound effects emerge in the case of energy efficiency. Past performance affects current levels pushing towards divergence. Evidence suggests that green taxation fosters energy efficiency whereas hinders environmental efficiency. The asymmetric operation of feedback loops and green taxation on energy and environmental efficiency highlights that horizontal policies hinder rather than foster green transition. This study contributes to SDGs 7, 12, 13 and 16.
Political ‘Colour’ and Firm Behaviour: Evidence from U.S. Power Plants’ Pollution Abatement
Authors: Di Maria Corrado , Lazarova Emiliya , Lange Lan 
Published: April 2024

AbstractWe ask whether firms behave differently depending on the political party in charge, above and beyond responding to any actual differences in policy. We use the pollution abatement behaviour of U.S. Steam Electric Power Plants under the Clean Water Act as our case study. Exploiting the variation provided by the outcome of tightly contested gubernatorial elections, we provide causal evidence that large firms respond to the political ‘colour’ of the governor in the state they operate, even when neither the stringency nor the enforcement of the rules depend on it. Within a theoretical model of the interaction between the regulator and the regulated firms, we show that multiple equilibria arise, and the outcomes of the election provide an effective coordination device. This unexpected behaviour has real-world consequences and leads to significant differences in pollution levels.
Hearing Behavioral Messages: Avoiding Misinterpretation to Make Effective, Inclusive Decisions
Authors: McGuire Stacy N. , VanUitert Victoria J. 
Published: April 2024

AbstractBehavior is a form of communication. For many young children, they may engage in certain behaviors to consciously or subconsciously communicate a need to access something, such as a desired adult or peer, sensory stimulation, or a tangible item. Other times, children may engage in a behavior to escape or avoid something, such as a particular environment. Sometimes the behaviors in which young children engage can be interpreted as challenging, based on the perceptions of those who work with the child, including the child’s early childhood teacher. These interpretations of challenging behavior derive from one’s own cultural backgrounds, beliefs, and biases. Such interpretations can lead to discriminatory discipline practices, particularly against children from marginalized and minoritized backgrounds. Instead, teachers can consider the behavioral messages expressed by the children they work with from an unbiased perspective, identify if the behavior in which the child is engaging is truly challenging, and implement appropriate intervention if necessary. The purpose of this paper is to present a plan for hearing behavioral messages of marginalized and minoritized children in a way that systematically addresses their needs while also considering the potential mismatch between teacher and child identities.