bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Usefulness of Basal FSH as a Prognostic Factor in Patients Undergoing Intracytoplasmic Sperm Injection*
Authors: Chae Hee‐Dong , Kim Chung‐Hoon , Kang Byung‐Moon , Chang Yoon Seok 
Published: May 2010

AbstractObjective: To determine if basal serum follicle stimulating hormone (FSH) level could be a prognostic factor of the clinical outcome in intracytoplasmic sperm injection (ICSI) cycles in the couples with male factor infertilityMaterials and Methods: From December 1995 to March 1998, total 118 patients underwent in vitro fertilization and embryo transfer (IVF‐ET) with ICSI due to male factor infertility were included in this study. Patients were allocated to the low basal FSH group (< 8.5 mIU/ml) and the high basal FSH group (< 8.5 mIU/ml). The basal levels of FSH were measured in the 3rd day of menstrual cycle preceding ovarian stimulation cycle in total IVF cycles by immunoradiometric assay (IRMA). Statistical analysis was performed using Student's t‐test, Fisher's exact test, and X2 test as appropriate. Statistical significance was defined as p < 0.05.Results: The total dose of exogeneous gonadotropin required in the high basal FSH group was significantly higher than that in the low basal FSH group. The numbers of retrieved oocytes and oocytes with grade I, II were significantly higher in the low basal FSH group. The clinical pregnancy rate per cycle in the low basal FSH group (16.2%) was significantly higher than that in the high basal FSH group (4.0%).Conclusion: These results suggested that the basal serum FSH levels could be predictive of pregnancy outcome and the results of controlled ovarian hyperstimulation (COH) in ICSI cycles.
Transvaginal Hysterosalpingo‐Contrast Sonography (HyCoSy) Compared with Chromolaparoscopy
Authors: Tanawattanacharoen Somchai , Suwajanakorn Somchai , Uerpairojkit Boonchai , Boonkasemsanti Wisut , Virutamasen Pramuan 
Published: May 2010

AbstractObjective: To compare the efficacy and safety of HyCoSy with chromolaparoscopy for the diagnosis of tubal occlusion and uterine abnormalities.Methods: Sixty infertile women in whom the cause of infertility was thought to be tubal occlusion or uterine abnormalities and who satisfied the inclusion and exclusion criteria as specified in the study protocol were included. HyCoSy was performed during the first half of the menstrual cycle at least 24 hours prior to chromolaparoscopy. The results from both HyCoSy and chromolaparoscopy were compared in assessing tubal occlusion and uterine pathology.Results: For the evaluation of fallopian tubes, we found corresponding results between HyCoSy and chromolaparoscopy in 80.0%. The agreement between both procedures in assessing the uterine pathology was 80.4%. Twenty‐two women experienced adverse events. The most common complaint was pelvic pain. Other events encountered were: nausea (3 women) and vaginal bleeding (2 women). All events were thought to be not related to the study drug.Conclusion: HyCoSy showed good diagnostic performance in the evaluation of the fallopian tubes and uterus in infertile women. The adverse events reported in this study are minor and procedure‐related (catheter insertion) rather than the trial substance.
Changes in the Serum Levels of Human Chorionic Gonadotropin and the Pulsatility Index of Uterine Arteries during Conservative Management of Retained Adherent Placenta
Authors: Matsumura Noriomi , Inoue Takuya , Fukuoka Masatsune , Sagawa Norimasa , Fujii Shingo 
Published: May 2010

AbstractObjective: Our purpose was to assess the natural course of retained adherent placenta at term.Methods: Five cases of retained adherent placenta, clinically diagnosed as placenta accreta, were managed conservatively without methotrexate. To assess the biochemical and circulatory changes in the placentas, the serum levels of human chorionic gonadotropin (hCG) and the pulsatility index (PI) of the uterine arteries were examined.Results: Serum hCG levels decreased spontaneously; the half‐life of serum hCG was calculated to be 5.2 ± 0.26 days (mean ± SEM). The PI of the uterine arteries remained at the level of pregnant women at term, but became elevated within a few days after the removal of the placentas. All the placentas were successfully removed transvaginally within 6 weeks postpartum.Conclusions: The changes in serum hCG observed in this study indicated the spontaneous degeneration of the placenta. Such changes might be similar to those reported to occur during treatment with methotrexate. In contrast, the PI of the uterine arteries did not reflect degeneration of the placenta.
A Retrospective Survey of Clinical, Pathologic, and Prognostic Features of Adnexal Masses Operated on during Pregnancy
Authors: Usui Rie , Minakami Hisanori , Kosuge Shuichi , Iwasaki Ryuhiko , Ohwada Michitaka , Sato Ikuo 
Published: May 2010

AbstractObjectives: To evaluate retrospective data concerning patients with adnexal masses that were managed surgically during pregnancy and their effect on fetal outcome.Methods: Data were reviewed concerning pregnant women who required surgery at our hospital between 1980 and 1997 for an adnexal mass.Results: In the past 19 years at our hospital a total of 69 Japanese women aged 28.5 ± 3.4 years (including 2 women with twin pregnancies) were diagnosed with adnexal masses that required surgery. The masses (10.2 ± 4.5 cm in the largest diameter) were removed at 13.9 ± 3.7 weeks of gestation. The pathologic features of the 69 lesions were as follows: 33 mature cystic teratomas, 13 functional cysts, 8 mucinous cystadenomas, 6 endometriotic cysts, 4 paraovarian cysts, 3 serous cystadenomas, and 2 malignant neoplasms. Of the 60 patients for whom the outcome of pregnancy was available, 7 (12%) gave birth before 37 weeks of gestation, while 2 (3.3%) experienced spontaneous abortions. There were 3 perinatal deaths among the 60 infants. Two of these 3 infants died due to major anomalies.Conclusions: Although larger studies are required for confirmation, our results suggest that an adnexal mass might be associated with an adverse fetal outcome. Surgical intervention at < 24 weeks of gestation per se might not have been related to the adverse outcomes. We emphasize that surgical intervention during pregnancy can be avoided in patients who have ultrasonographically pathognomonic features of benign cystic teratomas, which are the most common neoplasms operated on during pregnancy.
Anemia as a Risk Factor of Hemorrhagic Tendency during Surgery
Authors: Sagesaka Toshiaki , Juen Hiroyasu , Kaibara Makoto 
Published: May 2010

AbstractObjectives: Although it is well‐known that a hemorrhagic tendency in patients with massive bleeding during surgery, or with anemia before surgery, is difficult to control, its mechanism is still obscure.Study Design: Using a damped oscillation rheometer, we measured the initiation time (Ti) of whole blood with several concentrations of red blood cells (RBCs) and the Ti of platelet‐free plasma (PFP) with various concentrations of RBCs.Results: The Ti of the whole blood became prolonged according to the dilution of the RBC concentration. RBCs could coagulate the PFP, and the Ti of PFP also was prolonged according to the dilution of the RBC concentration.Conclusion: These results suggest that RBCs might have an important role as a phospholipid supplier in the intrinsic pathway of the blood‐coagulation mechanism. Anemia could thus represent a risk factor for hemorrhagic tendency during surgery due to lower RBC concentrations.
Comparison of Sex Chromosome Aneuploidy in Spermatozoa of Fertile Men and Those Requiring ICSI Treatment Detected by Fluorescence In Situ Hybridization*
Authors: Damri Louise E. , Vutyavanich Teraporn , Fishel Simon 
Published: May 2010

AbstractObjective: To compare the frequencies of aneuploidy for chromosomes X, Y and 18 in spermatozoa of infertile and fertile males, using 3‐color fluorescence in situ hybridization.Methods: Twelve infertile patients who underwent intracytoplasmic sperm injection treatment at Queen's Medical Centre, Nottingham were studied. Three fertile men served as controls. Aneuploidy frequencies in both groups were compared using 2‐sample t‐tests.Results: A total of 26,615 ad 93,649 cells were scored in the control and infertile groups respectively. The frequencies of diploidy, sex chromosome disomy and chromosome 18 disomy in the fertile (0.11, 0.28 and 0.11%) compared to the infertile males (0.05, 0.18 and 0.06%) were not statistically significantly different.Conclusion: Our preliminary data do not indicate an increased risk from paternal origin sex chromosome aneuploidies in ICSI. However, we recommend further investigations of the cytogenetic constitution of spermatozoa from severe male factor patients.
Post Partum Splenic Artery Aneurysm Rupture
Authors: Asokan S. , Chew E. K. , Ng K. Y. , Thanaletchimy N. , Asmiati A. , Kong N. M. 
Published: May 2010

AbstractRuptured splenic artery aneurysm during pregnancy is a rare event with high maternal and fetal mortality rate. A case of ruptured splenic artery aneurysm in the post partum period is presented. The literature is reviewed on pathophysiology, clinical presentation and management of this rare and potentially fatal entity.
A Clinicopathological Study of Postoperatively Upgraded Early Squamous‐Cell Carcinoma of the Uterine Cervix
Authors: Yoshida Manabu , Jimbo Haruko , Shirai Takako , Takahashi Michiko , Shiromizu Kenji , Kuwabara Yoshinori 
Published: May 2010

AbstractObjective:To investigate the clinicopathological backgrounds and diagnostic problems of postoperatively upgraded early squamous‐cell carcinomas of the uterine cervixPatients and Methods:A total of 23 patients with postoperatively upgraded early squamous‐cell carcinomas who were treated at the Saitama Cancer Center during the period of January 1, 1976, through December 31, 1991, were analyzed clinicopathologically. We reexamined the Pap smears (ectocervix, endocervix), colposcopic findings, punch biopsies, and histological findings of the operative specimens. All patients were divided into one of 3 groups based on each patient's main location of the carcinoma of the cervix:Type A: ectocervical type;Type B: endocervical type; orType C: combined (ectocervical and endocervical) type.Clinical staging of the uterine cervical carcinomas was done in accordance with the 1994 FIGO rules.Results:The numbers of patients were: Type A, 2; Type B, 10; Type C, 11. Of the 23 patients, 21 (91.3%) had lesions in the endocervical portion at least. Fifteen patients (65.2%) complained of atypical vaginal bleeding. Colposcopic findings suggesting an invasive carcinoma appeared for only 6 patients (26.1%). A cytological reevaluation revealed that the endocervical findings were much stronger than the ectocervical ones in 10 (66.7%) of 15 patients whose smears of both sites could be rechecked.Conclusions:Even if the preoperative diagnosis was early cervical carcinoma, CIS or Stage Ia1, the signs of atypical vaginal bleeding suggested that the final clinical stage would be upgraded after an operation. Furthermore, when the endocervical cytological findings were much more exaggerated than the ectocervical ones, the possibility of deeply invaded endocervical lesions should be considered.
Effectiveness of Second‐ and Third‐Generation Immunoassays for the Detection of Hepatitis C Virus Infection in Pregnant Women
Authors: Lin Ho‐Hsiung , Kao Jia‐Horng 
Published: May 2010

AbstractObjective: To compare the sensitivity and specificity of a third‐generation anti‐hepatitis C virus (anti‐HCV) assay (HCV 3.0) with second‐generation one (HCV 2.0), and correlate with HCV‐RNA positivity by reverse‐transcription polymerase chain reaction (RT‐PCR).Methods: We enrolled 197 pregnant women without screening for alanine aminotransferase (ALT) (Group A) and 324 pregnant women with elevated ALT activity (> 45 IU/l) (Group B). Each serum sample was tested by second‐ and third‐generation tests, and anti‐HCV titer was determined by serial dilutions. Anti‐HCV‐positive samples were subjected to HCV‐RNA assays.Results: Three (1.5%) and 4 (2.0%) of the 197 group A subjects were anti‐HCV‐positive by the second‐ and third‐generation methods, respectively, while 17 (5.3%) and 21 (6.5%) of group B were positive, respectively. Three (1.5%) in group A and 8 (2.5%) in group B were HCV 2.0‐negative, but positive for HCV 3.0. The sensitivity, specificity, positive and negative predictive values of HCV 2.0 and HVC 3.0 for positive HCV‐RNA in both groups were 67 vs 100%, 30 vs 75%, 67 vs 92%, and 30 vs 100%, respectively. The anti‐HCV‐positive samples with optical density (O.D.) < 1.0 either by second‐ or third‐generation test were negative for HCV‐RNA, whereas samples with O.D. < 1.0 were all HCV‐RNA‐positive.Conclusions: The performance of HCV 3.0 is better than that of HCV 2.0, and anti‐HCV‐positive samples with O.D. < 1.0 are negative for HCV‐RNA.
Uterine Leiomyoma Causing Massive Ascites and Left Pleural Effusion with Elevated CA 125: A Case Report
Authors: Migishima Fujio , Jobo Toshiko , Hata Hiroki , Sato Rinya , Ikeda Yasuhiro , Arai Masahide , Kuramoto Hiroyuki 
Published: May 2010

AbstractA 51‐year‐old patient presented with an abdominal mass and ascites as well as a left pleural effusion. Her serum CA125 was 820 U/ml. Surgical exploration revealed a benign leiomyoma of the uterus without malignant cytology in the ascites. Postoperatively, the pleural effusion was resolved dramatically and the CA125 decreased to the normal range after 4 months postoperatively. This is an extremely rare case of pseudo‐Meigs' syndrome caused by uterine leiomyoma.
Perinatal Risk Factors Related to Neurologic Outcomes of Term Newborns with Asphyxia at Birth: A Prospective Study*
Authors: Asakura Hirobumi , Ichikawa Hisashi , Nakabayashi Masao , Ando Kazuto , Kaneko Kazuhiko , Kawabata Masakiyo , Tani Akihiro , Satoh Masashi , Takahashi Katsuyuki , Sakamoto Shouichi 
Published: May 2010

AbstractObjectives: The incidence of poor neurologic outcomes was studied in term newborns who had suffered severe asphyxia at birth.Methods: Subjects were 152 newborns admitted to the NICU with a low Apgar score at 1 or 5 minutes. A 1‐year prospective follow‐up of neurological outcomes was carried out by a questionnaire survey concluded between April 1, 1996 and March 31, 1998.Results: 1) The incidence of a poor neurologic outcome, including 15 neurologic sequelae and 6 deaths, was 13.8% among the subjects. 2) The risk of a poor outcome was increased by 13‐fold in neonates with adverse neurological signs and 31‐fold in those with hypoxic ischemic encephalopathy.Conclusion: The incidence of poor neurologic outcome was very high among term infants with low Apgar scores. These infants were 10 times to 20 times more likely to die, or to survive with permanent disabilities, than were infants without low Apgar scores.
Primary Mucinous Adenocarcinoma of the Appendix: A Rare Entity in the Differential Diagnosis of Ovarian Cancer
Authors: Sehouli J. , Kopetsch O. J. , Ricke J. , Buchmann E. , Stengel D. , Riess H. , Weidemann H. , Schäper F. , Freiesleben W. , Lichtenegger W. 
Published: May 2010

AbstractWe report a 58‐year‐old female patient with the suspected diagnosis of ovarian cancer. Upon surgical exploration, examination of the appendix revealed the histological diagnosis of primary mucinous adenocarcinoma. This is an unusual consideration in the differential diagnosis of the ovarian cancer. We discuss the diagnosis, classification and treatment of the cancer of the appendix in relation to ovarian cancer.
Secondary Mitochondrial Dysfunction after Transient Intrauterine Ischemia in the Fetal Rat Brain*
Authors: Nakai Akihito , Taniuchi Yoshinari , Asakura Hirobumi , Yokota Akishige , Koshino Tatsuo , Araki Tsutomu 
Published: May 2010

AbstractObjective: Recirculation following transient intrauterine ischemia has previously been found to cause partial recovery and secondary deterioration of cellular bioenergetic states in the fetal rat brain. Our objective was to assess whether secondary bioenergetic failure is due to mitochondrial dysfunction.Study Design: Cerebral cortical tissues were obtained from 20‐day‐old fetal rats at the end of 30 minutes of intrauterine ischemia (n = 6) and after 1 hour (n = 6), 2 hours (n = 6), and 4 hours (n = 6) of recirculation. Mitochondrial respiratory activities were measured polarographically using homogenates.Results: Mitochondrial activities decreased to 45% of sham‐operated controls at the end of ischemia. Recirculation (1 hour) brought about partial recovery, but continued reflow (2 hours and 4 hours) was associated with a secondary deterioration of mitochondrial activities.Conclusion: The results indicate that although during the early time period after ischemia mitochondrial respiratory capacity is restored, secondary mitochondrial dysfunction develops in the immature rat brain.
Rapid Detection of Chromosome Aneuploidies by Prenatal Interphase FISH (Fluorescence in situ Hybridization) and Its Clinical Utility in Japan
Authors: Sawa Rintaro , Hayashi Zuisei , Tanaka Tadao , Onda Takekazu , Hoshi Kazuhiko , Fukada Yukihito , Takai Yasushi , Taketani Yuji , Kubo Takeshi , Hamada Hiromi , Yoshida Koyo , Nakamura Yasushi , Okai Takashi , Sakai Masato , Kaneoka Tsuyoshi , Makino Yasuo , Aono Toshihiro , Maeda Kazuhisa , Honda Ritsuo , Okamura Hitoshi , Sago Haruhiko , Kitagawa Michihiro , Minoura Shigeki , Inaba Junichi , Terakawa Naoki , Nagata Naoki , Shimomura Katsunori , Sapeta Michael J. , Estabrooks Laurel L. 
Published: May 2010

AbstractObjective: The purpose of this study was to assess the accuracy, informative rate, detection rate, and clinical utility of prenatal interphase fluorescence in situ hybridization (FISH) analysis of amniotic fluid samples from Japanese women.Methods:Amniotic fluid specimens from 2,639 Japanese women were received for prenatal interphase FISH and chromosome analysis. A questionnaire was designed to evaluate FISH clinical utility by collaboration sites.Results:Based on 2,319 tested samples, the accuracy (100%), informative (94%), and detection (87.6%) rates were all high. The accuracy (100%), informative (90.2%), and detection (90.0%) rates were also remarkable in third‐trimester pregnancies. We perceive significant advantages from this test regarding medical management and patient satisfaction.Conclusions:This novel report shows that in Japan prenatal interphase FISH testing is highly informative and accurate, not only in second‐trimester pregnancies but also in third‐trimester pregnancies. This test provides advantages to both physicians and patients, provided that its capabilities and limitations are understood.
Plasma Homocysteine, Fasting Insulin, and Androgen Patterns among Women with Polycystic Ovaries and Infertility
Authors: Sills E. Scott , Genton Marc Georges , Perloe Mark , Schattman Glenn L. , Bralley J. Alexander , Tucker Michael J. 
Published: May 2010

AbstractObjective: To measure plasma homocysteine, androgen, and insulin concentrations in women with normal and polycystic‐appearing ovaries in an infertility setting.Methods: Among women referred for infertility evaluation (n = 54), homocysteine, androstenedione, DHEAS, total testosterone, fasting insulin/glucose and methyltetrahydrofolate reductase (MTHFR) polymorphism status (C677T mutation) were studied. Ovaries were examined via transvaginal sonogram by one observer and scored as either normal (n = 18) or polycystic (n = 36).Results: When polycystic ovaries were identified, mean total testosterone was significantly higher than when non‐polycystic ovaries were present (p = 0.01), although no measured androgen was outside the normal reference range in either group. Average BMI was higher in the polycystic group, but the difference was not significant (p = 0.10). We observed a trend toward higher mean fasting insulin levels in women with polycystic ovaries, but this increase did not reach statistical significance (p = 0.07). Median plasma homocysteine was identical (7.0 mmol/l) in both populations, and no study subject exceeded the current recommended maximum reference value.Conclusions: In this population, the presence of polycystic ovaries was associated with higher serum androgens (especially total testosterone) although none of the measured androgens were above the normal range. While fasting insulin levels were also higher in this group, median plasma homocysteine levels were similar irrespective of ovarian morphology. Concomitant plasma homocysteine derangements in this population of young, lean patients with polycystic‐appearing ovaries seem unlikely. Further studies are needed to clarify the role(s) of homocysteine in human reproductive physiology.
Bilateral Jugular Venous Thromboembolism and Pulmonary Emboli in a Patient with Severe Ovarian Hyperstimulation Syndrome
Authors: Tavmergen Erol , Özçakir Hasan Tayfun , Levi Rafael , Adakan Şaban , Ulukuş Murat , Terek Mustafa Coşan 
Published: May 2010

AbstractWe report here a case of severe ovarian hyperstimulation syndrome with massive ascites in a 25‐year‐old woman with a history of primary infertility after an IVF‐ET cycle. At the 9th gestational week she presented with neck pain and dyspnea and duplex Doppler sonographic examination of the neck veins revealed bilateral jugular venous thrombosis. Despite prompt administration of low‐molecular weight heparin, pulmonary emboli developed a few days later.
Successful Laparoscopic Treatment of Ileo‐cecal Endometriosis Producing Bowel Obstruction
Authors: Fujimoto Akihisa , Osuga Yutaka , Tsutsumi Osamu , Fujii Tomoyuki , Okagaki Ryugo , Taketani Yuji 
Published: May 2010

AbstractBowel endometriosis manifesting with ileus is difficult to diagnose, often requiring laparotomy for diagnosis and treatment. We report here a case of ileo‐cecal endometriosis causing bowel obstruction. A diagnosis of intestinal endometriosis with menstruation‐associated bowel symptoms was made, and the patient was successfully treated by laparoscopic ileocecal resection.
Prenatal Diagnosis of Isolated Anorectal Atresia with Colonic Perforation
Authors: Tongsong Theera , Chanprapaph Pharuhus 
Published: May 2010

AbstractWe report here a case of prenatal diagnosis of isolated anorectal atresia with intrauterine colonic perforation at 34 weeks of gestation, characterized by the presence of a bilobed cystic pelvic mass with a V‐shape appearance separated from the bladder with changing features during observation. Mild ascites was also visualized. Other structures were normal on detailed ultrasound. The patient had spontaneously delivered a male infant weighing 2,100 g at 34 weeks of gestation. The infant died one day after birth, before surgical correction secondary to respiratory distress syndrome. Autopsy revealed isolated anorectal atresia, and high (supraelevator) lesions. In conclusion, the findings of bilobed cystic pelvic mass with a V‐shape were useful to diagnose anorectal atresia in this case. Prenatal ultrasound can facilitate early diagnosis and treatment.