bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Mechanically Tailored Gelatin‐Chondroitin Sulphate Hydrogel Films
Authors: Van Vlierberghe Sandra , Samal Sangram Keshari , Dubruel Peter 
Published: December 2011

AbstractThe aim of the present work was to develop and characterize biohybrid hydrogels containing combinations of gelatin and chondroitin sulphate. Two approaches have been compared. First, physisorption of chondroitin sulphate to gelatin hydrogels was investigated using surface plasmon resonance measurements. Due to the limited interaction between both biopolymers, we developed in a second approach methacrylate‐modified chondroitin sulphate hydrogels as such or in combination with methacrylamide‐modified gelatin. Rheology measurements indicated that following this approach, mechanically stable hydrogel films could be obtained after UV irradiation in the presence of Irgacure 2959 as UV photo‐initiator. When keeping the gelatin concentration and the modification degree constant, an increase in derivatization of the chondroitin sulphate component resulted in a high increase of the storage modulus.
The Influence of Zwitterionic Phospholipid Brushes Grafted via UV‐Initiated or SI‐ATR Polymerization on the Hemocompatibility of Polycarbonateurethane
Authors: Feng Yakai , Yang Dazhi , Behl Marc , Lendlein Andreas , Zhao Haiyang , Guo Jintang 
Published: December 2011

AbstractBiomimetic phosphorylcholine (PC) groups were introduced onto material surfaces in order to improve the hydrophilicity and in this way the hemocompatibility of polycarbonateurethanes (PCUs). Surface‐initiated atom transfer radical polymerization (SI‐ATRP) of 2‐methacryloyloxyethyl phosphorylcholine (MPC) initiated by irradiation with ultraviolet (UV) light created polymer brushes having PC side groups. Fourier transform infrared (FTIR), X‐ray photoelectron spectroscopy (XPS), scanning electrical microscopy (SEM) and water contact angle were used to characterize the chemical and physical properties of the modified PCU surfaces. The PC‐grafted PCU surfaces showed a significantly higher hydrophilicity as indicated by low water contact angles when compared with original PCU. The in vitro hemocompatibility of the PC‐grafted PCU surfaces was evaluated by platelet adhesion tests. The PCU surfaces modified with phosphorylcholine zwitterionic brushes showed effective resistance for platelet adhesion and high hemocompatibility. These PC‐grafted PCU materials might be potentially applied in blood‐contacting materials or devices due to their good mechanical and hemocompatible properties.
Selective Immobilization of Biomolecules on PTMC Network Surfaces Using Micro Contact Printing
Authors: Teixeira Sandra , González‐Campo Arancha , Cabanas‐Danés Jordi , Huskens Jurriaan , Jonkheijm Pascal , Grijpma Dirk W. 
Published: December 2011

AbstractUsing poly(trimethylene carbonate) (PTMC) network surfaces containing unreacted macromer methacrylate groups, thiol‐functionalized biotin (SH‐undecyl‐biotin) can be bound to the surface. With micro contact printing techniques and making use of the biotin‐streptavidin (SAv) binding system patterned surfaces with biological functionality can be prepared in a very straightforward manner. This method has high potential in numerous biomedical applications.
Functional Polymer Scaffolds for Blood Vessel Tissue Engineering
Authors: Diban Nazely , Stamatialis Dimitrios F. 
Published: December 2011

AbstractScaffold pore size plays a critical role in the infiltration of the cells into the structure. For engineered blood vessels, co‐cultures of endothelial (EC) on the lumen, and smooth muscle cells (SMC) on the external surface of tubular scaffolds are performed. The more adequate pore sizes for EC are, in general, smaller than for SMC. In the present work, poly(ε‐caprolactone) (PCL) flat film and hollow fibers are prepared by phase inversion. The influence of polymer and coagulation solution compositions on pore morphology of the films is analysed and the results are applied to obtain, in a one step process, PCL hollow fibers with suitable pore size for both EC and SMC.
Enhanced Collagen Type IV Based Differentiation of Embryonic Stem Cells Towards Flk‐1 Expressing Vascular Progenitors by the Wnt/β‐Catenin Synergist QS11
Authors: Poels Mark W. J. , Golbach Lieke A. , Poot André A. , Feijen Jan , Grijpma Dirk W. , Kruijer Wiebe 
Published: December 2011

AbstractMouse embryonic stem (mES) cells when plated onto collagen type IV in the presence of serum‐containing medium differentiate into a mixed cell population that contains low levels of Flk‐1 expressing vascular progenitor cells. When isolated and re‐plated onto collagen type IV, Flk‐1+ cells further differentiate into PECAM1+ endothelial and SMA+ mural cells. However, the low abundance and transient nature by which Flk‐1+ cells are generated during embryonic stem (ES) cell differentiation presents limitations in case large numbers of Flk‐1+ cells or its derivates are to be obtained. To optimize Flk‐1 progenitor induction from undifferentiated mES cells, the effects of QS11, a small organic molecule that synergistically activates canonical Wnt signalling, were investigated. In the presence of QS11 the percentage of Flk‐1+ cells in differentiating cultures of mES cells increases 1.5 fold. Furthermore, QS11 enhances cell proliferation in differentiating mES cells that results in a 2 fold increase in cell numbers when Flk‐1 induction is maximal. The combined effects of QS11 on differentiation and proliferation increase the efficiency by which Flk‐1 progenitors can be generated by approximately 300%, thereby providing a novel tool for vascular progenitor cell production for use in fundamental research and applications such as tissue engineering.
Novel Amphiphilic Mikto‐Arm Star‐Shaped Copolymers for the Preparation of PLA‐Based Nanocarriers
Authors: Cajot Sébastien , Riva Raphaël , Billiet Leen , Du Prez Filip , Alexandre Michaël , Lecomte Philippe , Jérôme Christine 
Published: December 2011

AbstractThree‐arm (A2B) and four‐arm (A2B2) star‐shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε‐caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an ω‐azide terminated PEO chains with PCL chain bearing one (A2B) or two (A2B2) alkyne functions at the middle of the chain by the copper mediated azide‐alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure.
Preparation and In Vivo Imaging of Lucifer Yellow Tagged Hydrogels
Authors: Möller Lena , Krause Andreas , Bartsch Ivonne , Kirschning Andreas , Witte Frank , Dräger Gerald 
Published: December 2011

AbstractThe synthesis of new Lucifer Yellow labeled hyaluronic acid‐ and alginate hydrogels that are covalently cross‐linked is reported. Biocompatibility and biodegradation of the fluorescent tagged hydrogel is investigated using an in vivo fluorescence imaging system.
Preparation of Three‐Dimensional Scaffolds from Degradable Poly(ether)esterurethane by Thermally‐Induced Phase Separation
Authors: Luetzow Karola , Weigel Thomas , Schossig Michael , Kratz Karl , Lendlein Andreas 
Published: December 2011

AbstractHighly porous scaffolds with an overall volume up to 30 cm3 and porosities in the range from 80% to 93% were prepared from degradable poly(ether)esterurethane by thermally‐induced phase separation (TIPS) and subsequent solvent sublimation. The variation of the polymer concentration when applying a fixed TIPS cooling protocol led to an adjustment in pore size as well as in pore size distribution. While polymer concentrations of 5, 7.5 and 10 wt% resulted in averaged pore sizes ranging from 70 to 90 µm with a broad pore size distribution (according to µ‐CT analysis) for polymer concentrations of 15 wt% a significant lower averaged pore size of 50 µm with a narrow pore size distribution was obtained.
Synthesis and Characterization of Polyetherimides with 3‐Methoxy‐1,2‐propanediol Moieties
Authors: Lange Maik , Luetzow Karola , Neffe Axel T. , Lendlein Andreas 
Published: December 2011

AbstractPolyetherimides have been evaluated as non‐toxic and steam‐sterilizable and are therefore potentially suited for biomedical applications. To enable a broader range of potential applications, polyetherimides with lower Tg, higher elasticity at room temperature and better processability are required. Our concept was to explore, whether the incorporation of 3‐methoxy‐1,2‐propanediol moieties in the main chain lead to a reduction of Tg and increase the elastic properties of the polymer compared to commercially available polyetherimides from 4,4′‐(4,4′‐isopropylidenediphenoxy)bis(phthalic anhydride) and 1,3‐diaminobenzene. Two different monomers were synthesized and co‐condensated with each other or using 4,4,4′‐(4,4′‐isopropylidenediphenoxy)bis(phthalic anhydride), respectively. The results proofed the successful synthesis and polymerization leading to polymers with molecular weights up to Mn = 6,400 g/mol. The polymers showed lowered Tg, resistance to heat up to 400 °C, tendencies to reduced contact angles and partially reduced E‐moduli in comparison to the commercial polyetherimide ULTEM 1000.
Synthesis and Characterization of Gelatin Fragments Obtained by Controlled Degradation
Authors: Piluso Susanna , Weigel Thomas , Lendlein Andreas , Neffe Axel T. 
Published: December 2011

AbstractTelechelic oligomers are attractive starting materials for the preparation of materials with tailorable properties. Here, peptide chains with defined molecular weight were obtained by controlled degradation of gelatin with hydroxylamine, which resulted in the cleavage of asparaginyl‐glycine bonds and formation of new aspartyl hydroxamates and amino endgroups. The reaction of gelatin with hydroxylamine resulted in fragments with molecular weights of 15, 25, 37, and 50 kDa (determined by SDS‐PAGE) independently of the reaction time and conditions. The fragment mixture showed typical single and triple helical organization in WAXS spectra, but rheological studies showed lower G′ and G″ values for gels from the fragment mixture than from gelatin, and lower gel‐sol transitions temperatures. A more narrow distribution was found for the fragment mixture (Mn = 25 kDa, PDI = 1.4) than for commercial gelatin.
Bilateral deep brain stimulation for cervical dystonia in patients with previous peripheral surgery
Authors: Capelle Hans‐Holger , Blahak Christian , Schrader Christoph , Baezner Hansjörg , Hariz Marwan I. , Bergenheim Tommy , Krauss Joachim K. 
Published: December 2011

AbstractBackground:There are no data available concerning whether patients with cervical dystonia who have recurrent or new symptoms after peripheral denervation surgery benefit similarly from pallidal deep brain stimulation compared with patients who receive primarily pallidal stimulation.Methods:Data on 7 cervical dystonia patients with recurrent or progressive dystonia after peripheral denervation who underwent pallidal stimulation were prospectively collected. Deep brain stimulation was performed in Mannheim/Hannover, Germany, or in Umea, Sweden. To the subgroup from Mannheim/Hannover, a second group of patients without previous peripheral surgery was matched. Assessments included the Toronto Western Spasmodic Torticollis Rating Scale and the Burke‐Fahn‐Marsden dystonia rating scale, as well as the Tsui scale in the Swedish patients.Results:The 4 patients from Mannheim/Hannover experienced sustained improvement from pallidal stimulation by a mean of 57.5% according to the Toronto Western Spasmodic Torticollis Rating Scale (P < .05) and by a mean of 69.5% according to the Burke‐Fahn‐Marsden dystonia rating scale (P < .05) at long‐term follow‐up of 40.5 months. The patients from Umea had a mean Tsui score of 7 prior to surgery and a mean score of 3 at the mean follow‐up of 8 months (62.5%). In the matched group the Toronto Western Spasmodic Torticollis Rating Scale improved by 58.8% and the Burke‐Fahn‐Marsden dystonia rating scale by 67% (P < .05) at long‐term follow‐up (mean, 41.5 months).Conclusions:Patients who had prior peripheral surgery for cervical dystonia experience improvement from subsequent pallidal stimulation that is comparable to that of de novo patients. © 2011 Movement Disorder Society
Eye symptoms in relatives of patients with primary adult‐onset dystonia
Authors: Defazio Giovanni , Abbruzzese Giovanni , Stella Aniello Maria , Di Fede Roberta , Esposito Marcello , Fabbrini Giovanni , Girlanda Paolo , Liguori Rocco , Marinelli Lucio , Martino Davide , Morgante Francesca , Santoro Lucio , Tinazzi Michele , Berardelli Alfredo 
Published: December 2011

AbstractMethods:Using a validated questionnaire, we screened eye symptoms (burning sensation, grittiness, dry eye) in 333 first‐degree relatives of 140 probands with different forms of primary adult‐onset dystonia, 208 healthy subjects, and 293 patients with primary blepharospasm.Results:The rate of eye symptoms was similar in the relatives of focal dystonia patients and in healthy subjects (adjusted HR, 1.1; 95% CI, 0.7–1.7; P = .69), thus suggesting a common origin of eye symptoms in both groups. A higher rate was observed in blepharospasm patients (adjusted HR, 2; 95% CI, 1.4–2.9; P < .0001). Relatives of focal dystonia patients who developed blepharospasm were more likely to have preceding eye symptoms than were relatives who developed focal dystonia other than blepharospasm (BSP) or relatives who did not develop dystonia.Conclusions:Eye symptoms reported by relatives of patients with focal dystonia probably result from eye diseases and are not part of the clinical spectrum of blepharospasm. © 2011 Movement Disorder Society
Dissociating between sensory and perceptual deficits in PD: More than simply a motor deficit
Authors: Martens Kaylena A. Ehgoetz , Almeida Quincy J. 
Published: December 2011

AbstractAlthough Parkinson's disease (PD) is traditionally considered a motor output disorder, recent evidence suggests that people with PD may have sensory and perceptual impairments that may underlie movement impairments. Yet there has not been any direct testing of perceptual judgments, especially when manipulating the sensory feedback on which these judgments are made. The present study investigated how perception might be influenced by sensory feedback to contribute to height estimations and obstacle stepping in PD relative to healthy age‐matched control participants. Perceptual judgment accuracy was evaluated by judging 3 typically encountered obstacle heights in 2 sensory feedback conditions: (1) vision of foot available and (2) without vision of foot (reliance on proprioceptive feedback to estimate height). Then participants proceeded to walk and step over the obstacle. Fifteen individuals with PD and 15 healthy control participants completed the task. As seen with toe elevation, toe elevation variability, and toe error measures, individuals with PD overestimated the obstacle height and were significantly more variable when relying solely on proprioception (in contrast to when vision was available) compared with healthy controls, although no differences between groups in obstacle crossing were found. These results support the notion that sensory deficits may contribute to inaccuracy of perceptual judgment and has the potential to contribute to gait behaviors such as tripping and falling, especially when vision is not available. Future studies should carefully consider the impact of sensory and perceptual deficits that might contribute to movement planning problems and consequentially movement impairments. © 2011 Movement Disorder Society
A motor signature of REM sleep behavior disorder
Authors: Oudiette Delphine , Leu‐Semenescu Smaranda , Roze Emmanuel , Vidailhet Marie , De Cock Valérie Cochen , Golmard Jean‐Louis , Arnulf Isabelle 
Published: December 2011

AbstractBackground:The purpose of this study was to determine if there was a common pattern in movements during REM sleep behavior disorder (RBD).Methods:We blindly compared video‐monitored movements during RBD (n = 136 clips) and wakefulness/arousal (n = 53 clips) in patients with Parkinson's disease (n = 29) and without parkinsonism (idiopathic RBD, n = 31; narcolepsy, n = 5).Results:The scorers accurately guessed the sleep/wake stage of 94% of video clips. Compared with wake movements, RBD movements were faster and more often repeated, jerky, and pseudohallucinatory, not self‐centered, never associated with tremor, and rarely involved the environment in an appropriate manner. A specific posture of the hand (limp wrist with flexed digits) during grasping movements was evidenced during RBD in 48% of patients, reminiscent of hand‐babbling in babies.Conclusions:These characteristics of movements were found in the 3 conditions (Parkinson's disease, idiopathic RBD, and primary narcolepsy), delineating a common motor signature of RBD. © 2011 Movement Disorder Society
A UWB bandpass filter with high performances using pair of multiple‐mode resonators
Authors: Cheng Wei , Wang XinHuai , Tuo Yong , Bai YanFu , Shi XiaoWei 
Published: December 2011

AbstractA microstrip line ultra‐wideband (UWB) bandpass filter with high performances using a pair of multiple‐mode resonators (MMRs) is proposed in this letter. A pair of MMRs and aperture on background are adopted in the filter to tighten the coupling strength of inter‐digital capacitor, and good impedance match is implemented by stepped impedance feeders so as to achieve high performances. Based on the design above, a UWB filter with high performances is simulated, fabricated, and measured. Simulated results show that the proposed filter has good UWB passband performances with insertion loss lower than 0.5 dB from 3.11 to 9.52 GHz and return loss higher than 20 dB from 3.28 to 10.36 GHz as well as group delay variation less than 0.1 ns. Good agreements are obtained between its measured and simulated results. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 54:289–292, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26547
Quadrature VCO based on an LC‐ring in 0.18‐μm CMOS technology
Authors: Jang Sheng‐Lyang , Chang Chia‐Wei , Shih Chih‐Chieh , Hsue Ching‐Wen 
Published: December 2011

AbstractIn this letter, a new LC‐ring quadrature voltage‐controlled oscillator (QVCO) is proposed. The proposed 0.18‐μm CMOS QVCO uses a new composite LC resonator, and it occupies the die area of 0.61 × 0.95 mm2. At the supply voltage of 1.2 V, the total power consumption is 3.7 mW. The free‐running frequency of the QVCO is tunable from 3.86 to 4.22 GHz as the tuning voltage is varied from 0.0 to 1.2 V. The measured phase noise at 1 MHz frequency offset is −123.42 dBc/Hz at the oscillation frequency of 3.94 GHz and the figure of merit of the proposed QVCO is −190.38 dBc/Hz. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 54:474–477, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26549
Design of a microstrip bandpass filter with wide stopband
Authors: Tang Ching‐Wen , Lai Hsuan‐Yu 
Published: December 2011

AbstractIn this work, a novel microstrip bandpass filter with a wide stopband is proposed. With the assistance of an open stub, one modified open‐circuit coupled line with symmetrical feeding, a long transmission line, and a wide stopband with a sufficient rejection level can be achieved. Detailed design and synthesis procedures are provided. Good agreement between simulation and measurement demonstrates feasibility of the proposed filter. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:549–551, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26557
Small planar internal wireless wide area network tablet computer antenna
Authors: Wong Kin‐Lu , Wu Tsung‐Ju 
Published: December 2011

AbstractA planar penta‐band wireless wide area network (WWAN) antenna with a small size of 12 × 35 mm2 for application in the tablet computer as an internal antenna is presented. The antenna is printed on a 0.8‐mm thick FR4 substrate on which a radiating portion and an antenna ground for accommodating a matching circuit are formed. The antenna is mounted at the top edge of the display ground which supports a 9.7‐inch display for the tablet computer. The antenna's radiating portion comprises a feeding strip, a parasitic strip short‐circuited to the antenna ground, and a printed distributed parallel resonant circuit. The latter two contribute a 0.25‐wavelength dual‐resonance mode at about 850 MHz for the GSM850/900 operation. The feeding strip generates a 0.25‐wavelength resonant mode at about 1800 MHz to combine with a higher‐order resonant mode at about 2200 MHz contributed by the shorted strip for the GSM1800/1900/UMTS operation. Additionally, the matching circuit on the antenna ground replacing the function of the matching circuit that is usually disposed on the system circuit board and provides a convenient means to adjust the impedance matching of the antenna to cover the desired operating bands. Owing to the new configuration of the antenna, the size of the proposed antenna is about the smallest among the internal WWAN antennas that have been reported for the tablet or laptop computer applications. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:426–431, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26559
Compact triple‐band antenna with rectangular ring for WLAN and WiMAX applications
Authors: Li Xin , Wang Ya‐Fang , Shi Xiao‐Wei , Hu Wei , Chen Lei 
Published: December 2011

AbstractA novel compact triple‐band antenna with rectangular ring for wireless local area network and worldwide interoperability for microwave access applications is proposed.The antenna is simply composed of a rectangular ring, a pair of symmetrical L‐shaped strips, and a T‐shaped monopole. Dual‐band characteristic can be produced by the pair of L‐shaped strips and T‐shaped monopole. By extending the rectangular ring from the ground plane, a new resonant frequency is obtained. Based on this concept, a prototype of this triple‐band antenna has been designed, fabricated, and measured. The experimental results show that the antenna covers the frequency bands 2.34–2.74, 3.04–3.82, and 5.03–6.05 GHz with −10 dB return loss. Moreover, good omnidirectional radiation patterns and reasonable gains are also obtained. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:286–289, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26561
Effective permeability of an S‐shaped resonator
Authors: Khan M. F. , Mughal M.J. , Bilal M. 
Published: December 2011

AbstractLeft‐handed material (LHM) is a hot topic of research due to its astonishing characteristics. S‐shaped resonator (SSR) is one of the resonators, which can be used to fabricate LHM. In this article, a simple expression for the effective permeability of SSR is presented and is verified by the experimental results. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 54:282–286, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26562