bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chrom
Authors: Schwedt Georg 
Published: August 2011

AbstractDas seit fast 200 Jahren bestehende Mineralogische Museum der Universität Bonn, das 1874 eine bedeutende Sammlung vom Gründer des heutigen Rheinischen Mineralien‐Kontors A. Krantz erhielt, zeigt unter anderem systematisch geordnet Minerale zu ausgewählten chemischen Elementen. Sie werden in dieser Serie zum Internationalen Jahr der Chemie 2011 näher vorgestellt.
Assessment of Clam Ruditapes philippinarum as Heavy Metal Bioindicators Using NMR‐Based Metabolomics
Authors: Liu Xiaoli , Zhang Linbao , You Liping , Yu Junbao , Cong Ming , Wang Qing , Li Fei , Li Lianzhen , Zhao Jianmin , Li Chenghua , Wu Huifeng 
Published: August 2011

AbstractThere are mainly distributed three pedigrees (White, Liangdao Red, and Zebra) of Manila clam Ruditapes philippinarum in Yantai population along the Bohai marine and coast. However, the biological differences to environmental stressors have been ignored in toxicology studies, which could lead to the distortion of biological interpretations of toxicological effects induced by environmental contaminants. In this study, we applied a system biology approach, metabolomics to compare the metabolic profiles in digestive gland from three pedigrees of clam and characterize and compare the metabolic responses induced by mercury in clam digestive gland tissues to determine a sensitive pedigree of clam as a preferable bioindicator for metal pollution monitoring and toxicology research. The most abundant metabolites, respectively, included branched‐chain amino acids, alanine, and arginine in White samples, glutamate, dimethylglycine, and glycine in Zebra clams and acetylcholine, betaine, glucose, and glycogen in Liangdao Red clams. After 48 h exposure of 20 µg L−1 Hg2+, the metabolic profiles from the three pedigrees of clams showed differentially significant changes in alanine, glutamate, succinate, taurine, hypotaurine, glycine, arginine, glucose, etc. Our findings indicate the toxicological effects of mercury exposure in Manila clams including the neurotoxicity, disturbances in energetic metabolisms and osmoregulation in the digestive glands and suggest that Liangdao Red pedigree of clam could be a preferable bioindicator for the metal pollution monitoring based on the more sensitive classes of metabolic changes from digestive glands compared with other two (White and Zebra) pedigrees of clams.
Metabolomic Study on the Halophyte Suaeda salsa in the Yellow River Delta
Authors: Liu Xiaoli , Zhang Linbao , You Liping , Wu Huifeng , Zhao Jianmin , Cong Ming , Li Fei , Wang Qing , Li Lianzhen , Li Chenghua , Han Guangxuan , Wang Guangmei , Xia Chuanhai , Yu Junbao 
Published: August 2011

AbstractPlant metabolomics has been well established and applied across multiple fields including medicine, biotechnology, and environmental sciences in the post‐genomic era. The Chenopodiaceae C3 halophyte Suaeda salsa is the most important plant species in the vegetation of saline soil and even intertidal zone in the Yellow River Delta, which is economically consumed as food, widely used as a bioindicator of environmental stresses (salinity, drought, and pollution) and typically applied for the phyto‐remediation of degraded wetland. However, no global studies have been focused on the metabolic profile of this halophyte which is widely applied in environment related research areas. In metabolomics, the first crucial step is the preparation of plant samples. In this work, several strategies of metabolite extraction from this C3 halophytes S. salsa were evaluated and the metabolic profile was characterized by NMR‐based metabolomics. Multiple replicates of plant tissues (approx. 250 mg whole fresh weight of leaves and stems) were homogenized by a high throughput automated Precellys 24 bead‐based homogenizer and then extracted using the following solvent systems of varying polarities: methanol, water, methanol/water, methanol/chloroform/water, and acetonitrile. The hydrophilic metabolites were analyzed using one‐dimensional proton NMR spectroscopy, and the subsequent NMR spectra were evaluated by principal components analysis (PCA). Each extraction protocol revealed unique metabolic profile from S. salsa. Overall, the quality of each extraction protocol was assessed based on the yield, reproducibility, ease, and speed, and we concluded that the solvent of methanol/water was preferable for the metabolite extraction due to its highest reproducibility, ease, and speed, and considerably high yield. Validation of methanol/water (1:1) solvent also showed a high degree of reproducibility with technical variation being considerably lower than biological variation in S. salsa samples. This demonstrated the quality and robustness of the methanol/water extraction method for NMR‐based metabolomics studies.
New Larvicidal Acetogenin from the Red Alga Laurencia papillosa
Authors: Abou‐Elnaga Zeinab S. , Alarif Walied M. , Al‐lihaibi Sultan S. 
Published: August 2011

AbstractA new C15 acetogenin, cyclic enyne (12E)‐cis‐maneonene‐E (1) and (12Z)‐trans‐maneonene‐B (2), together with different secondary metabolites including sesquiterpenoid 2,10‐dibromo‐3‐chloro‐α‐chamigrene (3) and fatty acid aldehydes (4–8) were isolated from the petroleum ether extract of a red alga, identified as Laurencia papillosa, collected from the Saudi Red Sea coast. The L. papillosa crude extract and its active ingredient acetogenin (1) have been evaluated for the ability to control two main economically important pests, the confused flour beetle larvae Tribolium confusum and Culex pipiens mosquito larvae. Compound 1 showed high potential as a natural insecticide against these two pests. In the case of T. confusum larvae, the LD50 values were 0.21 and 0.16% after 6 and 12 days of treatment with crude extract and acetogenin, respectively. On the other hand, the resulting LC50 values of mosquito larvae bioassay were 30.7, 36.9, and 41.8 ppm after 24 h treatment against 2nd, 3rd, and 4th larval instars, respectively. Also, an increase of the insecticidal effects against mosquito larvae was recorded after extending treatment time to 48 h.
Ecommerce interface colour and consumer decision making: Two routes of influence
Authors: J. Westerman S. , Sutherland E. J. , Gardner P. H. , Metcalfe R. , Nash J. , Palframan S. , Woodburn N. 
Published: August 2011

AbstractThis article reports an empirical study of the effects of interface colour (blue vs. grey) on ecommerce decision making. Participants viewed a set of products and information on the attributes of each and then made a series of purchase decisions that provided the basis for individual rankings of this set. Results support two proposed ‘routes of influence’. In the first, interface colour influences the cognitive capacities and strategies of consumers. This was evident as participants considered more attributes in the grey interface condition. Importantly, this was not mediated by participants' affective state. In the second, interface colour exerts influence via participants' aesthetic judgements. This was evident at a product‐specific level—with colour‐related differences in product selection decisions mediated (for two product alternatives) by participants' assessments of product aesthetics. There was also some support for a product‐generic effect of interface colour—with product aesthetics tending to be more influential in the grey condition. Overall, the results demonstrate the multifacetted nature of the influence of interface colour on consumer decision making in retail environments. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2011;
Spectroscopic Studies of Phosphazene Polymers Containing Photoluminescent Metal Complexes
Authors: Ainscough Eric W. , Allcock Harry R. , Brodie Andrew M. , Gordon Keith C. , Hindenlang Mark D. , Horvath Raphael , Otter Carl A. 
Published: August 2011

AbstractA series of small phosphazene ligands with pendant 6‐phenyl‐2,2′‐bipyridyl moieties, namely L1 [N3P3(OPh)5(OPhbpyPh)], L2 [N3P3(biph)2(OPhbpyPh)2], L3 [N3P3(tBubiph)2(OPhbpyPh)2], L4 [N3P3(biph)2(OPhbpyPh)Cl] and L5 [N3P3(biph)2(OPhbpyPh)(OPh)] [OPhbpyPh = 4‐(4‐phenoxy)‐6‐phenyl‐2,2′‐bipyridine, OPh = phenoxy, biph = 2,2′‐oxybiphenyl and tBubiph = 4,4′‐di‐tert‐butyl‐2,2′‐oxybiphenyl], have been used to synthesise the new cyclometallated palladium(II) and platinum(II) complexes [(L1‐H)PdCl], [(L1‐H)PtCl], [(L1‐H)(PdCl)2], [(L3‐H)(PdCl)2], [(L4‐H)PtCl], [(L5‐H)PtCl] and the rhenium(I) complex [L5Re(CO)3Cl]. Single‐crystal X‐ray diffraction analysis was performed on the free ligand L2 and the palladium complexes [(L1‐H)PdCl] and [(L3‐H)(PdCl)2]. In both PdII complexes, the metal centre lies in a distorted square‐planar geometry with an “N2CCl” donor set confirming the cyclopalladation. The ligand pendant arms are involved in intermolecular stacking interactions with adjacent molecules. A polyphosphazene (L6) with 4‐tert‐butylphenoxy (OtBuPh) and the potential donor OPhbpyPh as pendant groups was prepared and used to synthesise metallopolymers with ReI and PtII. Spectroscopic and computational studies were conducted to compare the discrete complexes with the polymers with similar metal pendants as well as to model compounds in the literature. By using UV/Vis and resonance Raman spectroscopic techniques it was found that very few deviations from known metal chromophores exist for both the triphosphazene‐ and polyphosphazene‐based complexes. The transient resonance Raman spectra of the PtII complexes revealed a ligand radical anion signature associated with the N2C unit.
ESR Study of Light‐Induced Valence Tautomerism of a Dinuclear Co Complex
Authors: Teki Yoshio , Shirokoshi Mugen , Kanegawa Shinji , Sato Osamu 
Published: August 2011

AbstractLight‐induced valence tautomerism (LIVT) of a dinuclear complex, [{Co(dpqa)}2(dhbq)](PF6)3 (1), was investigated by ESR analysis of dhbq3–. LIVT phenomena were observed in the sample diluted in the glass matrix as well as that in powder form. The signal decay and the relaxation were analyzed by double exponential fitting; the results suggest a two‐step mechanism. Quantum mechanical tunneling was clearly observed in the glass matrix.
Chiral Lanthanoid Dimers Ligated by Carbohydrate‐Based Diketonates: Catalytic and Luminescent Properties
Authors: Gee William J. , Hierold Judith , MacLellan Jonathan G. , Andrews Philip C. , Lupton David W. , Junk Peter C. 
Published: August 2011

AbstractThe reaction of hydrated lanthanoid chlorides (Ln = La, Eu) with chiral, carbohydrate‐based diketonate ligands has yielded dimeric species with Ln2L6 composition as determined by MALDI mass spectrometry and single‐crystal X‐ray crystallography. The X‐ray crystallographic analysis identified a chiral cavity formed by interligand repulsion able to coordinate dimethylformamide, prompting investigation of the catalytic properties of the dimers. Preliminary results indicate that the dimers display catalytic activity in thio‐Michael addition reactions as well as metal‐based luminescence in the case of europium.
Enyne‐Metathesis‐Based Tandem Processes (Eur. J. Org. Chem. 23/2011)
Authors: Li Jingwei , Lee Daesung 
Published: August 2011

AbstractThe cover picture shows a chain of dominoes in motion where one domino topples the one next to it, and so on. The individual dominoes symbolize elementary bond‐forming events by which simple alkene and alkyne building blocks are processed in tandem to form products of extended conjugation and polycyclic systems. Many enyne‐metathesis‐based tandem reactions developed and applied to the synthesis of natural and unnatural products are detailed in the Microreview by J. Li and D. Lee on p. 4269 ff.
Signal Enhancement of Electrochemical Biomemory Device Composed of Recombinant Azurin/Gold Nanoparticle
Authors: Lee Taek , Yoo Si‐Youl , Chung Yong‐Ho , Min Junhong , Choi Jeong‐Woo 
Published: August 2011

AbstractA signal‐enhanced biomemory device was developed by introducing cysteine‐modified azurin/gold nanoparticle (GNP) heterolayers. The proposed recombinant azurin/GNP heterolayers provided an enhanced electron transfer between recombinant azurin/GNP and the Au surface, which stored the charges in the fabricated heterolayer. The fabricated recombinant azurin/GNP heterolayers was investigated by atomic force microscopy (AFM) and surface plasmon resonance (SPR) spectroscopy. Cyclic voltammetry (CV) was performed to examine the current signal‐amplified electrochemical property. In this analysis, the recombinant azurin/GNP heterolayers produced current that was 5 times greater than the recombinant azurin monolayer. These redox potentials were then used to obtain the ‘write step’ and ‘erase step’. Using these parameters, the biomemory function of the device was verified by chronoamperometry (CA).
Electroanalysis at Salt – Cotton – Electrode Interfaces: Preconcentration Effects Lead to Nano‐Molar Hg2+ Sensitivity
Authors: Shariki Sara , Dale Sara E. C. , Marken Frank 
Published: August 2011

AbstractCotton is employed as a sample absorbent which is analysed sandwiched between a glassy carbon electrode and ammonium nitrate salt in a humidified argon atmosphere (ca. 80 % relative humidity). Exploratory experiments show that well‐defined voltammetric responses for the Fe(CN)63−/4− redox system pre‐absorbed into cotton are observed. Experiments with gold plating solution absorbed into cotton reveal the microscopic regions (cotton – glassy carbon contact points) of electrochemical activity where gold microparticles are plated onto the cotton surface. Stripping voltammetry experiments for trace metals such as Hg2+ pre‐absorbed into cotton show a surprisingly high sensitivity with nanomolar detection readily achieved.
Applying the Drosophila wing spot test to assess the genotoxic impact of 10 essential oil constituents used as flavouring agents or cosmetic ingredients
Authors: Mademtzoglou Despoina , Akmoutsou Paraskevi , Kounatidis Ilias , Franzios Gerasimos , Drosopoulou Elena , Vokou Despoina , Mavragani‐Tsipidou Penelope 
Published: August 2011

ABSTRACTThe genotoxicity of 10 essential oil constituents was evaluated using the Drosophila melanogaster (Meigen) somatic mutation and recombination test, also known as the wing spot test, in the frame of a screening project aiming at evaluating the mutagenic activity of widely used substances, natural or not. Of the compounds that we tested here, l‐carveol, dihydrocarveol, (+)‐dihydrocarvone, (−)‐fenchone and (−)‐carvyl acetate did not exhibit any mutagenic or recombinogenic activity, whereas (±)‐linalool, S‐(+)‐carvone and S‐(−)‐limonene gave inconclusive results. In contrast, α‐phellandrene and R‐(−)‐carvone significantly increased the frequency of mutant spots when compared with the negative control, suggesting mutagenic activity even at the lowest concentration used (1.5 µl/ml). Moreover, these data clearly demonstrate differences in activity between stereoisomers such as S‐(+)‐ and R‐(−)‐carvone. Given that α‐phellandrene and R‐(−)‐carvone are widely used compounds, further research is needed in order to have a better understanding of their activity and a clearer picture of their genotoxicity in order to decide whether they should remain or not in the lists of compounds that are safe to use. Copyright © 2011 John Wiley & Sons, Ltd.
Disruption of astrocytic glutamine turnover by manganese is mediated by the protein kinase C pathway
Authors: Sidoryk‐Wegrzynowicz Marta , Lee Eunsook , Mingwei Ni , Aschner Michael 
Published: August 2011

AbstractManganese (Mn) is a trace element essential for normal human development and is required for the proper functioning of a variety of physiological processes. Chronic exposure to Mn can cause manganism, a neurodegenerative disorder resembling idiopathic Parkinson's disease (PD). Mn(II) neurotoxicity is characterized by astrocytic impairment both in the expression and activity of glutamine (Gln) transporters. Because protein kinase C (PKC) activation leads to the downregulation of a number of neurotransmitter transporters and Mn(II) increases PKC activity, we hypothesized that the PKC signaling pathway contributes to the Mn(II)‐mediated disruption of Gln turnover. Our results have shown that Mn exposure increases the phosphorylation of both the PKCα and PKCδ isoforms. PKC activity was also shown to be increased in response to Mn(II) treatment. Corroborating our earlier observations, Mn(II) also caused a decrease in Gln uptake. This effect was blocked by PKC inhibitors. Notably, PKC activation caused a decrease in Gln uptake mediated by systems ASC and N, but had no effect on the activities of systems A and L. Exposure to α‐phorbol 12‐myristate 13‐acetate significantly decreased SNAT3 (system N) and ASCT2 (system ASC) protein levels. Additionally, a co‐immunoprecipitation studydemonstrated the association of SNAT3 and ASCT2 with the PKCδ isoform, and Western blotting revealed the Mn(II)‐mediated activation of PKCδ by proteolytic cleavage. PKC activation was also found to increase SNAT3 and ubiquitin ligase Nedd4‐2 binding and to induce hyperubiquitination. Taken together, these findings demonstrate that the Mn(II)‐induced dysregulation of Gln homeostasis in astrocytes involves PKCδ signaling accompanied by an increase in ubiquitin‐mediated proteolysis. © 2011 Wiley‐Liss, Inc.
Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
Authors: Bilezikian John P , Khan Aliya , Potts John T , Brandi Maria Luisa , Clarke Bart L , Shoback Dolores , Jüppner Harald , D'Amour Pierre , Fox John , Rejnmark Lars , Mosekilde Leif , Rubin Mishaela R , Dempster David , Gafni Rachel , Collins Michael T , Sliney Jim , Sanders James 
Published: August 2011

Abstract
Recent advances in understanding the epidemiology, genetics, diagnosis, clinical presentations, skeletal involvement, and therapeutic approaches to hypoparathyroidism led to the First International Workshop on Hypoparathyroidism that was held in 2009. At this conference, a group of experts convened to discuss these issues with a view towards a future research agenda for this disease. This review, which focuses primarily on hypoparathyroidism in the adult, provides a comprehensive summary of the latest information on this disease. © 2011 American Society for Bone and Mineral Research
Fetal transverse limb defects: Case series and literature review
Authors: Saeed Ferha , Paramasivam Gowrishankar , Wiechec Marcin , Kumar Sailesh 
Published: August 2011

AbstractPurpose.To investigate the incidence and outcome of antenatally diagnosed isolated transverse limb defects at a major tertiary center and to review the literature relevant to this rare condition.Methods.This was a retrospective review of all cases (2000–2009) diagnosed with an isolated transverse limb defect referred to a tertiary fetal medicine center. Isolated transverse limb defects were defined as partial or complete absence of a part of one or more limbs in the absence of other abnormalities.Results.Nine cases were identified. The upper limbs were affected in seven cases. The median gestational age at diagnosis was 22+5 weeks (range 21–29 weeks). The defects ranged from absence of digits to the absence of three limbs in one case. Four women opted to have termination of pregnancy. Postnatal and postmortem examination confirmed the ultrasound findings. No obvious risk factors could be identified in the majority of cases.Conclusions.Most cases of limb defects are believed to be secondary to a vascular insult occurring early in embryonic life. The reason for upper limb predominance remains unclear. Perinatal outcome in this series was poor with the majority of pregnancies terminated. Long‐term functional outcome depends on the severity of the limb reduction defect. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Prenatal 3D sonographic diagnosis of an isolated lateral facial cleft
Authors: Chang Yao‐Lung , Lien Reyin , Chang Shuenn‐Dyh , Chao An‐Shine 
Published: August 2011

AbstractWe report a case of lateral facial cleft (Tessier 7) diagnosed by sonography at a gestational age of 24 weeks. Two‐dimensional sonography revealed a fetus appropriate for gestational age without obvious anomaly, but a three‐dimensional sonogram with surface mode rendering showed asymmetrical macrostomia as a result of a left lateral facial cleft. Our case highlights the advantage of using three‐dimensional sonography in the prenatal diagnosis of lateral facial clefts. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Prenatal diagnosis of aortopulmonary window
Authors: Aslan Halil , Corbacioglu Aytul , Yildirim Gokhan , Ceylan Yavuz 
Published: August 2011

AbstractAortopulmonary window (APW) is a rare congenital heart malformation. It refers to a connection between the ascending aorta and the pulmonary trunk before bifurcation. We report a case of APW that was detected by prenatal fetal echocardiography. The diagnosis was confirmed postnatally with an additional partial anomalous pulmonary venous connection. Corrective surgery was performed at the age of 1 week. Prenatal diagnosis of APW is important because an operation early after birth is required to prevent congestive heart failure due to high pulmonary blood flow. It is essential to visualize the aortopulmonary septum during fetal echocardiographic examination. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011
Cyanoacetamide in heterocyclic chemistry: Synthesis, antitumor and antioxidant activities of some new benzothiophenes
Authors: El Bialy Serry A. A. , Gouda Moustafa A. 
Published: August 2011

AbstractCyanoacylation of 2‐amino‐tetrahydrobenzothiophene‐3‐carboxylate ethyl ester with 3‐(3,5‐dimethyl‐1H‐pyrazol‐1‐yl)‐3‐oxopropanenitrile afforded cyanoacetamide 2. The later was utilized as key intermediate for the synthesis of 3‐substituted 2‐iminocoumarins 3, 4, 5, 6 and acrylamides 7a, b via Knoevenagel condensation with 2‐hydroxy‐1‐naphthaldehyde; 2‐hydroxybenzaldehyde; 1‐nitrosonaphthalen‐2‐ol; 7‐hydroxy‐5‐methoxy‐2‐methyl‐4‐oxo‐4H‐chromene‐6‐carbaldehyde; 4‐dimethylamino‐benzaldehyde; and 4‐piperidin‐1‐yl‐benzaldehyde in EtOH/piperidine. The derivatives 7a, b did not afford the pyrazoles 8a, b upon treating with phenyl hydrazine. Furthermore, coupling of 2 with 4‐amino‐1,5‐dimethyl‐2‐phenyl‐1H‐pyrazol‐3(2H)‐one and 4,6‐dimethyl‐1H‐pyrrolo[2,3‐b]pyridin‐3‐amine afforded the hydrazone derivatives 9 and 10, respectively. The later derivative 10 was cyclized in acetic acid to afford the pyridopyrazolotriazine 11. Finally, 2 was treated with dimethylformamide‐dimethylacetal (DMF‐DMA) to afford the dimethylaminoacrylamide 12 which underwent transamination with 4,6‐dimethyl‐1H‐pyrrolo[2,3‐b]pyridin‐3‐amine to afford the pyrazole 13. Cyclization of compound 13 in acetic acid or pyridine was unsuccessful. The antitumor and antioxidant activities of the synthesized products were evaluated; several were found to exhibit promising antioxidant activities. J. Heterocyclic Chem., (2011).
Novel sulfenamides as promising acetylcholinesterase inhibitors
Authors: Proença Carla , Serralheiro M. Luísa , Araújo M. Eduarda , Pamplona Teresa , Santos Susana , Santos M. Soledade , Frazão Fátima 
Published: August 2011

AbstractSeveral sulfenamide derivatives were designed as possible acetylcholinesterase (AChE) inhibitors. New sulfenamides were synthesized and proved to be stable under the physiological conditions used in the enzymatic assays. N‐benzyl‐2‐benzoxazolylsulfenamide (8) and N‐benzyl‐2‐benzimidazolylsulfenamide (9) revealed anti‐AChE activity with IC50 values of 0.6 and 0.8 μM, respectively, values of the same magnitude as those reported for galantamine and tacrine. The affinity for the biological site was evaluated in terms of interaction/partition toward sodium dodecyl sulfate (SDS) micelles. The inhibitory activity profiles were reasoned in terms of both partition toward a hydrophobic anionic environment and molecular geometry. The XCSN dihedral angle deviations from collinearity stood out as a major parameter linked to enzyme specificity. J. Heterocyclic Chem., (2011).