bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing resonance frequency analysis assessed by Osstell™mentor during implant tissue integration: II. Implant surface modifications and implant diameter
Authors: Han Jie , Lulic Martina , Lang Niklaus P. 
Published: April 2010

AbstractObjectives: To monitor the development of the stability of Straumann® tissue‐level implants during the early phases of healing by resonance frequency analysis (RFA) and to determine the influence of implant surface modification and diameter.Material and methods: A total of twenty‐five 10 mm length implants including 12 SLA RN ∅4.1 mm implants, eight SLActive RN ∅4.1 mm implants and five SLA WN ∅4.8 mm implants were placed. Implant stability quotient (ISQ) values were determined with Osstell™mentor at baseline, 4 days, 1, 2, 3, 4, 6, 8 and 12 weeks post‐surgery. ISQ values were compared between implant types using unpaired t‐tests and longitudinally within implant types using paired t‐tests.Results: During healing, ISQ decreased by 3–4 values after installation and reached the lowest values at 3 weeks. Following this, the ISQ values increased steadily for all implants and up to 12 weeks. No significant differences were noted over time. The longitudinal changes in the ISQ values showed the same patterns for SLA implants, SLActive implants and WB implants. At placement, the mean ISQ values were 72.6, 75.7 and 74.4, respectively. The mean lowest ISQ values, recorded at 3 weeks, were 69.9, 71.4 and 69.8, respectively. At 12 weeks, the mean ISQ values were 76.5, 78.8 and 77.8, respectively. The mean ISQ values at all observation periods did not differ significantly among the various types. Single ISQ values ranged from 55 to 84 during the entire healing period. Pocket probing depths of the implants ranged from 1 to 3 mm and bleeding on probing from 0 to 2 sites/implant post‐surgically.Conclusions: All ISQ values indicated the stability of Straumann® implants over a 12‐week healing period. All implants showed a slight decrease after installation, with the lowest ISQ values being reached at 3 weeks. ISQ values were restored 8 weeks post‐surgically. It is recommended to monitor implant stability by RFA at 3 and 8 weeks post‐surgically. However, neither implant surface modifications (SLActive) nor implant diameter were revealed by RFA. To cite this article:
Han J, Lulic M, Lang NP. Factors influencing resonance frequency analysis assessed by Osstell™mentor during implant tissue integration: II. Implant surface modifications and implant diameter. Clin. Oral Impl. Res. 21, 2010; 605–611. doi: 10.1111/j.1600‐0501.2009.01909.x
Transmucosal healing around peri‐implant defects: crestal and subcrestal implant placement in dogs
Authors: Tran Binh L. T. , Chen Stephen T. , Caiafa Anthony , Davies Helen M. S. , Darby Ivan B. 
Published: April 2010

AbstractObjective: This study was designed to evaluate the transmucosal healing response of implants placed with the junction of the smooth surfaces, either crestal or subcrestal, into simulated extraction defects after healing periods of 1 and 3 months.Materials and methods: A total of 23 Straumann SP ∅3.3 mm NN, SLA® 10 mm implants were placed in the mandibular premolar regions of three greyhound dogs 3 months after the teeth were removed. Five control implants were placed at the crestal bone level, and test implants with surgically created peri‐implant defects of 1.25 mm wide × 5 mm depth were placed either at the crestal (nine implants) or at the 2 mm subcrestal (nine implants) bone level. Implants on the right side were placed 1 month before the dogs were sacrificed, and implants on the left side were placed 3 months before sacrifice. All dogs had daily plaque control following surgery and were sacrificed 3 months after implant placement for histological and histometric analyses.Results: Mesial–distal ground sections of the control and test implant specimens showed a greater %BIC in the coronal defect region after 3 months of healing. This healing response was incomplete for the test implants compared with the control implants after a 1‐month healing period. The histometric measurements for test implants placed at the crestal bone level or 2 mm subcrestal with surgically created peri‐implant defects were more coronal or closer to the implant margin compared with the control implants. Additionally, the degree of osseointegration between the newly formed bone and the implant surface was similar between the test implants.Conclusion: Peri‐implant defects of 1.25 mm width healed with spontaneous bone regeneration around implants placed transmucosally at crestal or 2 mm subcrestal with a high degree of osseointegration after a 3‐month healing period. To cite this article:
Tran BLT, Chen ST, Caiafa A, Davies HMS, Darby IB. Transmucosal healing around peri‐implant defects: crestal and subcrestal implant placement in dogs. Clin. Oral Impl. Res. 21, 2010; 794–803. doi: 10.1111/j.1600‐0501.2010.01911.x
Long‐term implant survival and success: a 10–16‐year follow‐up of non‐submerged dental implants
Authors: Simonis Pierre , Dufour Thomas , Tenenbaum Henri 
Published: April 2010

AbstractObjectives: The aim of the present study was to evaluate the long‐term results of dental implants using implant survival and implant success as outcome variables.Methods: Of the 76 patients who received 162 implants of the Straumann Dental Implant System during the years 1990–1997, 55 patients with 131 implants were recalled 10–16 years after implant placement for a complete clinical and radiographic examination, followed by a questionnaire that examined the degree of satisfaction. The incidence of biological and technical complications has been carefully analysed for each implant. Success was defined as being free of all these complications over the entire observation period. Associated factors related to peri‐implant lesions were analysed for each implant.Results: The long‐term implant cumulative survival rate up to 16 years was 82.94%. The prevalence of biological complications was 16.94% and the prevalence of technical complications was 31.09%. The cumulative complication rate after an observation period of 10–16 years was 48.03%, which meant that substantial amounts of chair time were necessary following implant placement. The majority of implant losses and biological complications were concentrated in a relatively small number of patients.Conclusion: Despite a relatively high long‐term survival rate, biological and technical complications were frequent. Patients with a history of periodontitis may have lower implant survival rates than patients without a history of periodontitis and were more prone to biological complications such as peri‐implant mucositis and peri‐implantitis. To cite this article: Simonis P, Dufour T, Tenenbaum H. Long‐term implant survival and success: a 10–16‐year follow‐up of non‐submerged dental implants. Clin. Oral Impl. Res. 21, 2010; 772–777 doi: 10.1111/j.1600‐0501.2010.01912.x
Establishment of a streptozotocin‐induced diabetic domestic pig model and a systematic evaluation of pathological changes in the hard and soft tissue over a 12‐month period
Authors: Von Wilmowsky Cornelius , Stockmann Philipp , Metzler Philipp , Harsch Igor Alexander , Amann Kerstin , Schlegel Karl Andreas 
Published: April 2010

Abstract:Objective: The number of diabetic patients in need of medical treatment is growing steadily. Therefore, a diabetic animal model with high degree of similarities with humans, which is suitable for the systematic evaluation of biomaterials and medical devices, is needed.Materials and methods: Twenty domestic pigs were used for the study. Fifteen received Streptozotocin (STZ) to induce diabetes mellitus. Internal parameters were measured and bone as well as soft tissues biopsies were taken after 0, 6 and 12 months and evaluated qualitatively and quantitatively by means of scanning electronic microscopy, light microscopy and microradiography.Results: The results of the clinical internal parameters, determined by the American Diabetes Association for the definition of diabetes mellitus could be fulfilled. Pathological changes of the skin vasculatures were already visible after 6 months with a significant wall thickening in the diabetic group. The bone mineralization was lower in the diabetic group after 6 months and with a significant difference after 12 months.Conclusion: From the present results, it can be concluded that a STZ dosage of 90 mg/kg body weight in the domestic pig is suitable for the induction of an apparent diabetes, leading to histolopathological changes in the hard and soft tissues already after 6 months. The high degree of similarities with humans makes it an interesting diabetic animal model for biomaterial research in a compromised animal model. To cite this article: von Wilmowsky C, Stockmann P, Metzler P, Harsch IA, Amann K, Schlegel KA. Establishment of a streptozotocin‐induced diabetic domestic pig model and a systematic evaluation of pathological changes in the hard and soft tissue over a 12‐month period. Clin. Oral Impl. Res. 21, 2010; 709–717. doi: 10.1111/j.1600‐0501.2010.01914.x
Effects of dose reduction on multi‐detector computed tomographic images in evaluating the maxilla and mandible for pre‐surgical implant planning: a cadaveric study
Authors: Koizumi Hiroshi , Sur Jaideep , Seki Kenji , Nakajima Koh , Sano Tsukasa , Okano Tomohiro 
Published: April 2010

AbstractObjective: To assess effects of dose reduction on image quality in evaluating maxilla and mandible for pre‐surgical implant planning using cadavers.Materials and methods: Six cadavers were used for the study using multi‐detector computed tomography (CT) operated at 120 kV and the variable tube current of 80, 40, 20 and 10 mA. A slice thickness of 0.625 mm and pitch 1 were used. Multi‐planar images perpendicular and parallel to dentitions were created. The images were evaluated by five oral radiologists in terms of visibility of the anatomical landmarks including alveolar crest, mandibular canal, floors of the maxillary sinus and nasal cavity, contours/cortical layer of jaw bones and the details of trabecular bone. Observers were asked to determine the quality of the images in comparison with 80 mA images based on the criteria: excellent, good, fair or non‐diagnostic. The average scores of all observers were calculated for each specimen in all exposure conditions.Results: The 40 mA images could visualize such landmarks and were evaluated to be same or almost equivalent in quality to the 80 mA images. Even the 20 mA images could be accepted just for diagnostic purpose for implant with substantial deterioration of the image quality. The 10 mA images may not be accepted because of the obscured contour caused by image noise.Conclusion: Significant dose reduction by lowering mA can be utilized for pre‐surgical implant planning in multi‐detector CT. To cite this article:
Koizumi H, Sur J, Seki K, Nakajima K, Sano T, Okano T. Effects of dose reduction on multi‐detector computed tomographic images in evaluating the maxilla and mandible for pre‐surgical implant planning: a cadaveric study. Clin. Oral Impl. Res. 21, 2010; 830–834. doi: 10.1111/j.1600‐0501.2010.01925.x
Early loading of single crowns supported by 6‐mm‐long implants with a moderately rough surface: a prospective 2‐year follow‐up cohort study
Authors: Rossi Fabio , Ricci Emanuele , Marchetti Claudio , Lang Niklaus P. , Botticelli Daniele 
Published: April 2010

AbstractAim: To evaluate prospectively the clinical and radiographic outcomes after 2 years of loading of 6 mm long moderately rough implants supporting single crowns in the posterior regions.Material and methods: Forty SLActive Straumann® short (6 mm) implants were placed in 35 consecutively treated patients. Nineteen implants, 4.1 mm in diameter, and 21 implants, 4.8 mm in diameter, were installed. Implants were loaded after 6 weeks of healing. Implant survival rate, marginal bone loss and resonance frequency analysis (RFA) were evaluated at different intervals. The clinical crown/implant ratio was also calculated.Results: Two out of 40 implants were lost before loading. Hence, the survival rate before loading was 95%. No further technical or biological complications were encountered during the 2‐year follow‐up. The mean marginal bone loss before loading was 0.34±0.38 mm. After loading, the mean marginal bone loss was 0.23±0.33 and 0.21±0.39 mm at the 1‐ and 2‐year follow‐ups. The RFA values increased between insertion (70.2±9) and the 6‐week evaluation (74.8±6.1). The clinical crown/implant ratio increased with time from 1.5 at the delivery of the prosthesis to 1.8 after 2 years of loading.Conclusion: Short implants (6 mm) with a moderately rough surface loaded early (after 6 weeks) during healing yielded high implant survival rates and moderate loss of bone after 2 years of loading. Longer observation periods are needed to draw more definite conclusions on the reliability of short implants supporting single crowns. To cite this article:
Rossi F, Ricci E, Marchetti C, Lang NP, Botticelli D. Early loading of single crowns supported by 6‐mm‐long implants with a moderately rough surface: a prospective 2‐year follow‐up cohort study. Clin. Oral Impl. Res. 21, 2010; 937–943. doi: 10.1111/j.1600‐0501.2010.01942.x
Review article: Phenytoin use and efficacy in the ED
Authors: Gallop Katharine 
Published: April 2010

AbstractThis article reviews the evidence regarding the use of phenytoin in adult and paediatric patients experiencing seizures in the ED in Australasia, including relevant pharmacokinetics, dosage, therapeutic drug monitoring and methods of administration. It summarizes current evidence regarding the use of phenytoin in a number of seizure types commonly seen in ED. A search of Medline, Embase and Cochrane was performed using appropriate keyword and MeSH headings. A loading dose of phenytoin should be given to phenytoin naïve patients for the emergency treatment of seizures; parenteral administration results in therapeutic concentration sooner than oral administration but is associated with more frequent and significant adverse effects. Diluting phenytoin is safe but there is limited evidence regarding adverse effects of diluted phenytoin; a filter is probably not needed. Free phenytoin concentrations correlate best with antiseizure efficacy. Phenytoin is used in the treatment of status epilepticus although evidence here is limited; it may also be given to prevent early post‐traumatic seizures. It should not be given to treat or prevent eclamptic or alcohol‐related seizures. There is insufficient evidence regarding its use in preventing febrile convulsions, treating or preventing seizures due to space occupying lesions or intracerebral haemorrhage and thrombosis. In conclusion, phenytoin is appropriate for treatment of some seizures seen in the ED; it is associated with significant adverse effects; trials are ongoing regarding the use of other anticonvulsants in the treatment of status epilepticus.
Ultrasound‐assisted peripheral vascular access in a paediatric ED
Authors: Oakley Ed , Wong Ai‐Ming 
Published: April 2010

AbstractObjectives:  To assess the implementation and utility of US for assisting peripheral venous access in a paediatric ED.Methods:  A prospective, observational study of a convenience sample comparing the landmark and US‐guided technique for peripheral vascular access in children from July 2006 to February 2007. Clinicians involved under went 3 months of training in US physics and with practical models. Clinicians estimated the degree of difficulty of insertion (using a Likert scale) before each line placement. Data including time of procedure and success or failure were collected, using a standardized clinical record form, by an observing researcher.Results:  A total of 84 patients were enrolled. There were 61 line placement episodes in the landmark group (with 253 attempts), and 38 in the US group (with 90 attempts). US recorded slightly higher success per attempt overall (42% vs 38%, P= 0.08), and performed better in the patients with difficult access (success 35% vs 18%, P= 0.003). US attempts took longer than landmark attempts (2 min 15 s vs 4 min, P < 0.001).Conclusion:  The US guidance may improve the success rate of peripheral vascular access in children rated to have difficult or very difficult vascular access.
Sex Steroid Receptors in Male Human Bladder: Expression and Biological Function
Authors: Chavalmane Aravinda K. , Comeglio Paolo , Morelli Annamaria , Filippi Sandra , Fibbi Benedetta , Vignozzi Linda , Sarchielli Erica , Marchetta Matilde , Failli Paola , Sandner Peter , Saad Farid , Gacci Mauro , Vannelli Gabriella B. , Maggi Mario 
Published: April 2010

ABSTRACT

Introduction
In male, lower urinary tract symptoms (LUTS) have been associated, beside benign prostatic hyperplasia, to some unexpected comorbidities (hypogonadism, obesity, metabolic syndrome), which are essentially characterized by an unbalance between circulating androgens/estrogens. Within the bladder, LUTS are linked to RhoA/Rho-kinase (ROCK) pathway overactivity.

Aim
To investigate the effects of changing sex steroids on bladder smooth muscle.

Methods
ERα, ERβ, GPR30/GPER1 and aromatase mRNA expression was analyzed in male genitourinary tract tissues, and cells isolated from bladder, prostate, and urethra. Estrogen and G1 effect on RhoA/ROCK signaling output like cell migration, gene expression, and cytoskeletal remodeling, and [Ca2+]i was also studied in hB cells. Contractile studies on bladder strips from castrated male rats supplemented with estradiol and testosterone was also performed.

Main Outcome Measures
The effects of classical (ERα, ERβ) and nonclassical (GPR30/GPER1) estrogen receptor ligands (17β-estradiol and G1, respectively) and androgens on RhoA/ROCK-.mediated cell functions were studied in hB cells. Contractility studies were also performed in bladder strips from castrated male rats supplemented with testosterone or estradiol.

Results
Aromatase and sex steroid receptors, including GPR30, were expressed in human bladder and mediates several biological functions. Both 17β-estradiol and G1 activated calcium transients and induced RhoA/ROCK signaling (cell migration, cytoskeleton remodeling and smooth muscle gene expression). RhoA/ROCK inhibitors blunted these effects. Estrogen-, but not androgen-supplementation to castrated rats increased sensitivity to the ROCK inhibitor, Y-27632 in isolated bladder strips. In hB cells, testosterone elicited effects similar to estrogen, which were abrogated by blocking its aromatization through letrozole.

Conclusion
Our data indicate for the first time that estrogen-more than androgen-receptors up-regulate RhoA/ROCK signaling. Since an altered estrogen/androgen ratio characterizes conditions, such as aging, obesity and metabolic syndrome, often associated to LUTS, we speculate that a relative hyperestrogenism may induce bladder overactivity through the up-regulation of RhoA/ROCK pathway.
Fluoxetine-Induced Decrements in Sexual Responses of Female Rats and Hamsters Are Reversed by 3α,5α-THP
Authors: Frye Cheryl A. , Rhodes Madeline E. 
Published: April 2010

ABSTRACT

Introduction
Sexual dysfunction, as a result of selective-serotonin reuptake inhibitor (SSRI) treatment among women, is relatively common and is a factor in medication compliance. The mechanisms that underlie these side-effects of SSRIs are not well-understood. SSRIs can alter activity of catabolic enzymes that are involved in progesterone’s conversion to 5α-pregnan-3α-ol-20-one (3α,5α-THP). 3α,5α-THP plays a key role in female reproductive physiology and behavior.

Aims
This study aimed to determine whether 3α,5α-THP, in the midbrain ventral tegmental area (VTA) may be a potential mechanism for fluoxetine’s reduction in sexual responding of female rodents. We hypothesized that if fluoxetine induces decrements in sexual responding in part through actions of 3α,5α-THP, then fluoxetine will inhibit sexual receptivity concomitant with reducing 3α,5α-THP levels, effects which can be reversed by 3α,5α-THP administration.

Methods
Experiment 1 investigated effects of acute systemic fluoxetine [20 mg/kg intraperitoneal (IP)] and/or 3α,5α-THP [500 µg, subcutaneous (SC)] administration on sexual responding of ovariectomized, hormone-primed rats. Experiment 2 examined effects of 3α,5α-THP administration to the midbrain VTA (100 ng) on fluoxetine-induced decrements in lordosis of ovariectomized, hormone-primed rats and hamsters.

Main Outcome Measures
Sexual responding was determined in rats and hamsters. For rats, the percentage of times that the lordosis response occurred following mounting by a sexually-vigorous male (lordosis quotients) was utilized. For hamsters, lateral displacement, the pelvic movement that females will make to facilitate intromissions by a male hamster, was utilized.

Results
Fluoxetine significantly reduced lordosis, and this was reversed SC 3α,5α-THP. Intra-VTA 3α,5α-THP attenuated fluoxetine’s detrimental effects on lordosis quotients and lateral displacement of rats and hamsters, respectively.

Conclusions
Thus, fluoxetine’s effects to disrupt female sexual responses may involve its effects on progestogens in the midbrain VTA.
Efficacy of Udenafil for the Treatment of Erectile Dysfunction up to 12 Hours after Dosing: A Randomized Placebo-Controlled Trial
Authors: Park Hyun Jun , Park Jong Kwan , Park Kwangsung , Min Kweonsik , Park Nam Cheol 
Published: April 2010

ABSTRACT

Introduction
Udenafil is a newly developed selective phosphodiesterase type 5 inhibitor for the treatment of men with erectile dysfunction (ED).

Aim
To evaluate the efficacy of udenafil in treating ED for up to 12 hours after dosing.

Methods
This was a randomized, double-blind, placebo-controlled, parallel-group, fixed dose design, multicenter study. Following a 4-week nondrug baseline period, 104 men with ED of broad etiology and severity were randomized to one of two treatment groups: udenafil 100 mg or placebo. Participants were requested to attempt sexual intercourse at 12 hours after udenafil or placebo dosing during a 4-week treatment period.

Main Outcome Measures
The primary efficacy variable was the response of patients to question 3 of the Sexual Encounter Profile (SEP Q3). The secondary efficacy measures were the response of patients to question 2 of the Sexual Encounter Profile (SEP Q2). Additional secondary efficacy measures included changes from baseline in the erectile function (EF) domain scores of the International Index of Erectile Function (IIEF) questionnaire.

Results
Of the 104 patients, 103 (50 in the udenafil group, 53 in the placebo group) completed the study. Udenafil significantly enhanced the rate of maintenance of erection (SEP Q3; placebo, 28.3% vs. udenafil, 54.7%; P &lt;0.0001). Significant change from baseline in the IIEF-EF domain was observed in the udenafil group (placebo, –0.58 ± 0.67; udenafil, 4.40 ± 0.84; P &lt;0.0001). For SEP Q2, there was no difference from baseline and no difference between the two groups. The overall adverse events rate was 11.3%. Most adverse events were mild or moderate in severity, and no serious adverse events were reported during the study and the follow-up period.

Conclusions
Udenafil at 100 mg was effective for relieving ED for up to 12 hours after dosing. This duration of effectiveness could allow for flexibility and spontaneity in the sexual lives of patients.