bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perancangan Motion Comic Cerita Pewayangan Bima dan Dewa Ruci untuk Masalah Krisis Identitas pada Remaja
Authors: Ardiyansyah Riyan , Kurniawan Rahmat , Poerbaningtyas Evy 
Published: May 2024

Krisis identitas pada remaja berpotensi membuat remaja melakukan kegiatan negatif. Remaja dalam mencari jati diri ada beberapa bentuk problem perilaku yang paling umum dialam yang berakar adanya hambatan dalam proses perkembangan adalah depresi, kenakalan dan penyalahgunaan narkotika. Perancangan ini bertujuan untuk mengetahui bagaimana proses merancang motion comic sebagai media edukasi untuk remaja dalam memahami identitasnya. Metode yang digunakan dalam perancangan ini adalah Design Thinging, kemudian Metode prolehan data yang digunakan perancang yang diperoleh menggunakan analisis 5W+1H, wawancara,studi literasi, dokumen dan pencarian di internet, dengan pendekatan kualitatif. Hasil uji coba alpa dan beta dari perancangan motion comic cerita bima dan dewa ruci untuk krisis identitas pada remaja, dapat diambil kesimpulan bahwa, video motion comic bisa digunakan untuk penunjang media pembelajan, akan tetapi untuk perubahan psikologi dan karakter, tanyangan video motion comic dengan alur cerita yang disampaikan belum efektif
Biomechanical study of a biplanar double support screw (BDSF) technique based on Pauwels angle in femoral neck fractures: finite element analysis
Authors: Tang Zhongjian , Zhang Yazhong , Huang Shaolong , Zhu Zhexi , Zhou Chengqiang , Zhu Ziqiang , Wang Yunqing , Wang Bin 
Published: May 2024

ObjectiveThe objective of the present study is to conduct a comparative analysis of the biomechanical advantages and disadvantages associated with a biplanar double support screw (BDSF) internal fixation device.MethodsTwo distinct femoral neck fracture models, one with a 30° angle and the other with a 70° angle, were created using a verified and effective finite element model. Accordingly, a total of eight groups of finite element models were utilized, each implanted with different configurations of fixation devices, including distal screw 150° BDSF, distal screw 165° BDSF, 3 CLS arranged in an inverted triangle configuration, and 4 CLS arranged in a “α” configuration. Subsequently, the displacement and distribution of Von Mises stress (VMS) in the femur and internal fixation device were assessed in each fracture group under an axial load of 2100 N.ResultsAt Pauwels 30° Angle, the femur with a 150°-BDSF orientation exhibited a maximum displacement of 3.17 mm, while the femur with a 165°-BDSF orientation displayed a maximum displacement of 3.13 mm. When compared with the femoral neck fracture model characterized by a Pauwels Angle of 70°, the shear force observed in the 70° model was significantly higher than that in the 30° model. Conversely, the stability of the 30° model was significantly superior to that of the 70° model. Furthermore, in the 70° model, the BDSF group exhibited a maximum femur displacement that was lower than both the 3CCS (3.46 mm) and 4CCS (3.43 mm) thresholds.ConclusionThe biomechanical properties of the BDSF internal fixation device are superior to the other two hollow screw internal fixation devices. Correspondingly, superior biomechanical outcomes can be achieved through the implementation of distal screw insertion at an angle of 165°. Thus, the BDSF internal fixation technique can be considered as a viable closed reduction internal fixation technique for managing femoral neck fractures at varying Pauwels angles.
Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy
Authors: Basar Oyku Yagmur , Mohammed Sawsan , Qoronfleh M. Walid , Acar Ahmet 
Published: May 2024

Metronomic chemotherapy (MCT), characterized by the continuous administration of chemotherapeutics at a lower dose without prolonged drug-free periods, has garnered significant attention over the last 2 decades. Extensive evidence from both pre-clinical and clinical settings indicates that MCT induces distinct biological effects than the standard Maximum Tolerated Dose (MTD) chemotherapy. The low toxicity profile, reduced likelihood of inducing acquired therapeutic resistance, and low cost of MCT render it an attractive chemotherapeutic regimen option. One of the most prominent aspects of MCT is its anti-angiogenesis effects. It has been shown to stimulate the expression of anti-angiogenic molecules, thereby inhibiting angiogenesis. In addition, MCT has been shown to decrease the regulatory T-cell population and promote anti-tumor immune response through inducing dendritic cell maturation and increasing the number of cytotoxic T-cells. Combination therapies utilizing MCT along with oncolytic virotherapy, radiotherapy or other chemotherapeutic regimens have been studied extensively. This review provides an overview of the current status of MCT research and the established mechanisms of action of MCT treatment and also offers insights into potential avenues of development for MCT in the future.
Change in prosocial development following adversity exposure among U.S. Mexican youth
Authors: Carlo Gustavo , White Rebecca , Curlee Alexandra , Tein Jenn-Yun , Partovi Roushanac , Knight George , Gonzales Nancy 
Published: May 2024

IntroductionAltruistic prosocial behaviors (i.e., actions primarily intended to benefit others with little to no regard for self-benefit) are of special interest to researchers interested in growth in character strengths following exposure to adversity and trauma (referred to as the altruism-born-of-suffering hypothesis). The present study was designed to examine this hypothesis. Changes in prosocial behaviors following trauma exposure and whether problem-focused coping and familism facilitated prosocial behaviors were investigated in U.S. Mexican youth.MethodsA total of 749 Mexican-origin students (initial M age = 10.42 years, SD = 0.55; 48.9% girls) from the U.S. Southwest completed surveys from 5th grade to early adulthood.ResultsU.S. Mexican girls who reported earlier trauma exhibited increases in altruistic behaviors into young adulthood but only when they reported relatively high levels of familism values in middle adolescence. A similar trend pattern was found for U.S. Mexican boys but only when they expressed relatively high levels of problem-focused coping in middle adolescence. There was other evidence of significant relations between both familism and problem focused coping and prosocial behaviors in these youth.DiscussionFindings demonstrate the potential for prosocial development across adolescence to young adulthood among trauma-exposed youth from a U.S. ethnic/racial minority background.
Information literacy skills of health professions students in assessing YouTube medical education content
Authors: Pearlman Orianne , Konecny Lynda Tierney , Cole Matthew 
Published: May 2024

IntroductionYouTube is a popular social media video platform used by health professions students for medical education. YouTube videos vary in quality, and students need to be able to evaluate and select high-quality videos to supplement their learning. Evaluating the quality of YouTube videos is an essential information literacy skill, and the Association of College and Research Libraries updated the framework of information literacy to include collaborative platforms such as YouTube. Research is needed to understand and explore the information literacy proficiency of students in the health professions who are using YouTube videos as learning resources.MethodsThis exploratory expert-novice study investigated the information literacy proficiency of students in evaluating the quality of medical education YouTube videos. Students (n = 89) and experts (n = 23) evaluated three preselected medical education YouTube videos of varying quality using the Medical Quality Video Evaluation Tool (MQ-VET).ResultsResults of two-way mixed repeated-measures ANOVA found experts assigned significantly lower ratings to low- and medium-quality videos than students. In other words, students were less information proficient in selecting videos due to overrating source credibility, education quality, and production quality, along with having lower expectations and finding videos more useful.DiscussionThe tendency of students to overrate lower-quality videos raises concerns about their selection of educational content outside structured learning environments. If students select videos to watch outside the classroom, they could unintentionally learn medical skills from low-quality videos. These insights suggest a need for teachers to select only high-quality videos for students and for more focused curricular strategies to enhance students’ abilities in critically assessing YouTube resources for medical education.
Relationship between the longitudinal trajectory of the triglyceride-glucose index and the development of CKD: an 8-year retrospective longitudinal cohort study
Authors: Hou Qinchuan , Zhang Huiwang , Zhang Rui , Li Binghong , Li Lei , Li Dongyu , Wang Xian , Liu Yuping , Wan Zhengwei , Zhang Junlin , Shuai Ping 
Published: May 2024

BackgroundThe triglyceride-glucose (TyG) index, a simple surrogate marker of insulin resistance, is significantly associated with chronic kidney disease (CKD). However, there is limited research on the longitudinal trajectory of TyG index over time and its relationship with CKD.ObjectiveTo analyse the characteristics of the longitudinal trajectory of the TyG index over time and its association with the development of CKD in a health check-up population.MethodsParticipants who underwent at least three annual health check-ups at the Health Management Center of Sichuan Provincial People’s Hospital from 2015 to 2022 were included in this retrospective cohort study. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. The latent class mixed model (LCMM) was used to identify the TyG index trajectory of the study population. A Cox proportional hazard model was used to estimate the CKD incidence risk in different quartile groups and the association of changes in the TyG index trajectory with the development of CKD.ResultsA total of 4,921 participants were included in this study, and they were divided into four groups according to the quartiles of the baseline TyG index: Q1 (5.43-6.66), Q2 (6.67-7.04), Q3 (7.05-7.43), and Q4 (7.43-9.97). There was no difference in the risk of CKD occurrence among the TyG groups. Three different TyG index trajectories were identified in this study: a high-level group, middle-level stable group and low-level stable group, respectively. The incidence rate of CKD in the high-level TyG index trajectory group was 2.399 times greater than that in the low-level stable trajectory group (HR=2.399, 95% CI 1.167-4.935).ConclusionIndividuals with long-term exposure to high TyG index levels had a significantly greater risk of CKD. Routine monitoring of the TyG index and its longitudinal trend will aid in the risk stratification of CKD in the general population and will be helpful for CKD prevention and targeted management.
Study on low-carbon service mode of park-level integrated energy system with flexible supply and demand balance
Authors: Pan Hua , Li Yanji , Liu Rong , Zhu Huimin 
Published: May 2024

Against the backdrop of “carbon peaking and carbon neutrality” goals in China, the park-level integrated energy system is a significant approach to meeting the energy consumption demand of users and improving the utilization rate of new energy. To take into account both the interests of integrated energy services (IES) providers and the current power market rules in China, targeting at low-carbon energy consumption, a balancing service mode for integrated energy services providers is created herein based on the idea of balancing multiple interests of regional integrated energy services providers. It aims to break down the market barriers and address the tricky problem that the integrated energy services industry fails to establish a sophisticated industrial system under the original mode. Combining the integrated energy services with the auxiliary market of power balance, the paper analyzes the characteristics of energy flow within the system, and puts forward the optimization scheme of regional integrated energy balancing services under the low-carbon background. The objective is solved by Mayfly algorithm and compared for analysis, and the results show that the optimal daily operating cost is 2632.59 yuan and the daily carbon emission is 3869.90 kg under the typical industrial scenario. The examples provided here show that the optimization plan for integrated energy balancing services can reduce carbon emissions from the park-level integrated energy system and boost the revenue for integrated energy service providers. It provides theoretical support for the green transformation of energy enterprises and promotes the healthy development of the global integrated energy industry.
Simulation and multi-scenario prediction of land-use change in the Gansu section of the Yellow River Basin, China
Authors: Ma Xin , Li Jie , Li Guang 
Published: May 2024

Introduction: The Gansu section of the Yellow River Basin is an important water resource conservation and replenishment area for the entire Yellow River Basin. With urbanization and socio-economic development, it is urgent to study the characteristics of land-use change and its future simulation in order to realize the coordinated ecological and economic development.Methods: Based on the patch-generating land-use simulation (PLUS) model, this paper investigated the main drivers of land-use type expansion with a comprehensive consideration of natural and socio-economic aspects; moreover, the study simulated land-use change in 2030 under the four scenarios of natural development, cultivated land protection, ecological priority, and economic construction.Results: The results showed the following: 1) the prediction of land-use types continued the historical evolution since 1980. Grassland, cultivated land, and forest land were still the dominant land types, accounting for more than 87% of the basin’s total area. Water bodies and wetlands remained relatively stable, and there was an obvious increase of approximately 20% in construction land. 2) Construction land and grassland were primarily driven by the social factor of the distance from the primary road and the distance from the secondary road, respectively. The cultivated land was greatly affected by the economic factor of population density. 3) The cultivated land protection scenario was the only one of the four scenarios that could make the cultivated land area increase positively, with an increase rate of 0.5%. This scenario also restricted effectively the conversion of cultivated land into construction land. The ecological priority scenario can expand grassland obviously with a proportion of 1.82% and slow down oasis desertion. The economic construction scenario can increase the construction land area the most by a rate of 25.5% to accelerate the economic development of specific regions in the study area.Discussion: Therefore, implementing policies on the basis of choosing suitable scenarios in different areas was significant for optimizing the land-use structure, promoting the efficient use of land resources and ecological environment in the Gansu section of the Yellow River Basin.
Soil organic carbon, pH, and ammonium nitrogen controlled changes in bacterial community structure and functional groups after forest conversion
Authors: Cao Xiaoqing , Xia Kai , Zhao Hongfei , Deng Pengfei , Teng Zhen , Xu Xiaoniu 
Published: May 2024

IntroductionLand-use changes significantly impact soil properties in forests, which is an area of concern. Therefore, the effects of changing forest types on soil microbial communities and their functions in northern subtropical forest regions need to be further researched.MethodsWe used 16S rDNA sequencing and Functional Annotation of Prokaryotic Taxa (FAPROTAX) to assess the variation of soil bacterial communities and potential functions related to carbon (C) and nitrogen (N) cycling in two soil layers (0–10 and 10–30 cm) after the conversion of the secondary masson pine (Pinus massoniana, PM) forest to plantations of slash pine (Pinus elliottii, PE) and Chinese fir (Cunninghamia lanceolata, CL) located in Jingde County, Anhui Province, China.ResultsThe study found that converting coniferous secondary forests to coniferous plantations resulted in a notable increase in soil pH and a decrease in nitrate nitrogen and organic carbon contents. Additionally, soil microbial diversity increased significantly, and microbial community structure changed, particularly in the topsoil. These changes might affect the C- and N-cycling mediated by soil bacteria. The analysis revealed a significant decrease in the abundance of functional groups associated with C-cycling and a significant increase in the abundance of functional groups associated with N-cycling, particularly those associated with denitrification. Soil organic carbon, pH, and ammonium nitrogen were the most critical variables affecting changes in the soil microbial community.DiscussionThese findings provide valuable information for ecological restoration and future sustainable forest management.
Genome-wide identification analysis in wild-type Solanum pinnatisectum reveals some genes defending against Phytophthora infestans
Authors: Shen Chunxiu , Lu Qineng , Yang Di , Zhang Xueru , Huang Xinping , Li Rungen , Que Zhiqun , Chen Na 
Published: May 2024

Solanum pinnatisectum exhibits strong resistance to late blight caused by Phytophthora infestans but only an incomplete genome assembly based on short Illumina reads has been published. In this study, we generated the first chromosome-level draft genome for the wild-type potato species S. pinnatisectum in China using Oxford Nanopore technology sequencing and Hi-C technology. The high-quality assembled genome size is 664 Mb with a scaffold N50 value of 49.17 Mb, of which 65.87% was occupied by repetitive sequences, and predominant long terminal repeats (42.51% of the entire genome). The genome of S. pinnatisectum was predicted to contain 34,245 genes, of which 99.34% were functionally annotated. Moreover, 303 NBS-coding disease resistance (R) genes were predicted in the S. pinnatisectum genome to investigate the potential mechanisms of resistance to late blight disease. The high-quality chromosome-level reference genome of S. pinnatisectum is expected to provide potential valuable resources for intensively and effectively investigating molecular breeding and genetic research in the future.
Dynamic changes of immunocyte subpopulations in thermogenic activation of adipose tissues
Authors: Ye Yuqing , Wang Huiying , Chen Wei , Chen Zhinan , Wu Dan , Zhang Feng , Hu Fang 
Published: May 2024

ObjectivesThe effects of cold exposure on whole-body metabolism in humans have gained increasing attention. Brown or beige adipose tissues are crucial in cold-induced thermogenesis to dissipate energy and thus have the potential to combat metabolic disorders. Despite the immune regulation of thermogenic adipose tissues, the overall changes in vital immune cells during distinct cold periods remain elusive. This study aimed to discuss the overall changes in immune cells under different cold exposure periods and to screen several potential immune cell subpopulations on thermogenic regulation.MethodsCibersort and mMCP-counter algorithms were employed to analyze immune infiltration in two (brown and beige) thermogenic adipose tissues under distinct cold periods. Changes in some crucial immune cell populations were validated by reanalyzing the single-cell sequencing dataset (GSE207706). Flow cytometry, immunofluorescence, and quantitative real-time PCR assays were performed to detect the proportion or expression changes in mouse immune cells of thermogenic adipose tissues under cold challenge.ResultsThe proportion of monocytes, naïve, and memory T cells increased, while the proportion of NK cells decreased under cold exposure in brown adipose tissues.ConclusionOur study revealed dynamic changes in immune cell profiles in thermogenic adipose tissues and identified several novel immune cell subpopulations, which may contribute to thermogenic activation of adipose tissues under cold exposure.
Individual and population-level variability in HLA-DR associated immunogenicity risk of biologics used for the treatment of rheumatoid arthritis
Authors: Sugiyama Naonobu , Terry Frances E. , Gutierrez Andres H. , Hirano Toshitaka , Hoshi Masato , Mizuno Yasushi , Martin William , Yasunaga Shin’ichiro , Niiro Hiroaki , Fujio Keishi , De Groot Anne S. 
Published: May 2024

HypothesisWhile conventional in silico immunogenicity risk assessments focus on measuring immunogenicity based on the potential of therapeutic proteins to be processed and presented by a global population-wide set of human leukocyte antigen (HLA) alleles to T cells, future refinements might adjust for HLA allele frequencies in different geographic regions or populations, as well for as individuals in those populations. Adjustment by HLA allele distribution may reveal risk patterns that are specific to population groups or individuals, which current methods that rely on global-population HLA prevalence may obscure.Key findingsThis analysis uses HLA frequency-weighted binding predictions to define immunogenicity risk for global and sub-global populations. A comparison of assessments tuned for North American/European versus Japanese/Asian populations suggests that the potential for anti-therapeutic responses (anti-therapeutic antibodies or ATA) for several commonly prescribed Rheumatoid Arthritis (RA) therapeutic biologics may differ, significantly, between the Caucasian and Japanese populations. This appears to align with reports of differing product-related immunogenicity that is observed in different populations.Relevance to clinical practiceFurther definition of population-level (regional) and individual patient-specific immunogenic risk profiles may enable prescription of the RA therapeutic with the highest probability of success to each patient, depending on their population of origin and/or their individual HLA background. Furthermore, HLA-specific immunogenicity outcomes data are limited, thus there is a need to expand HLA-association studies that examine the relationship between HLA haplotype and ATA in the clinic.