bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical effectiveness and cost-effectiveness of a multidisciplinary team-based approach to the management of community residents with hypertension: an analysis of an interventional follow-up study
Authors: Xu Yingjie , Du Xiushuai , Jin Yan , Wu Yitian , Wu Shuli , Yue Jingwen , Wang Xueting , Shen Hong , Zhao Yue , Xia Weibing , Yang Lihong , Huang Shan , Dong Xiaoyan , Wang Haiyin , Zheng Weiwei , Jiang Li 
Published: May 2024

Abstract

Background
This study assessed the medical effectiveness and cost-effectiveness of a multidisciplinary team (MDT)-based interventional follow-up in managing hypertension, thereby serving as an evidence base for decision-making in disease prevention and control for community residents.
Methods
We randomly assigned 5,676 community residents in Shanghai’s Changning District to the intervention or the control group and followed them up for two years.
Results
The mean BP of the intervention group decreased from 132.28/79.55 mmHg to 130.73/77.62 mmHg after the follow-up. The prevalence of hypertension in the intervention group (86.1%, n = 2,450) was lower than in the control group (89.8%, n = 2,510) (odds ratio (OR) = 1.30, 95% confidence interval (CI): 1.09–1.58, P = 0.004). The ICER of the intervention group was ¥6,837 ($989.135, £792.135) in cost analysis, with the threshold of cost-effectiveness set as the incremental costs per QALY, which was 0.63 times China’s 2017 GDP (gross domestic product) per capita (¥59,960). Additionally, the incremental costs of the intervention group totaled ¥5,128.394 with a QALY value of 2.018, while those of the control group were ¥4,855.406 with a QALY value of 1.978. The ICER of ¥6,837/QALY in the intervention group was far less than 0.63 times China’s 2017GDP per capita (¥59,960), suggesting the economic feasibility of the interventional strategy.
Conclusions
The MDT-based intervention is a highly cost-effective strategy, and it effectively reduces the prevalence of hypertension in community residents, the occurrence of MACEs, and the mortality rate from CVDs while providing scientific medication guidance.
Trial registration: item number 134119b2200.
Road traffic noise and breast cancer: DNA methylation in four core circadian genes
Authors: Thacher Jesse D. , Snigireva Anastasiia , Dauter Ulrike Maria , Oudin Anna , Mattisson Kristoffer , Sørensen Mette , Borgquist Signe , Albin Maria , Broberg Karin 
Published: May 2024

Abstract

Background
Transportation noise has been linked with breast cancer, but existing literature is conflicting. One proposed mechanism is that transportation noise disrupts sleep and the circadian rhythm. We investigated the relationships between road traffic noise, DNA methylation in circadian rhythm genes, and breast cancer. We selected 610 female participants (318 breast cancer cases and 292 controls) enrolled into the Malmö, Diet, and Cancer cohort. DNA methylation of CpGs (N = 29) in regulatory regions of circadian rhythm genes (CRY1, BMAL1, CLOCK, and PER1) were assessed by pyrosequencing of DNA from lymphocytes collected at enrollment. To assess associations between modelled 5-year mean residential road traffic noise and differentially methylated CpG positions, we used linear regression models adjusting for potential confounders, including sociodemographics, shiftwork, and air pollution. Linear-mixed effects models were used to evaluate road traffic noise and differentially methylated regions. Unconditional logistic regression was used to investigate CpG methylation and breast cancer.
Results
We found that higher mean road traffic noise was associated with lower DNA methylation of three CRY1 CpGs (CpG1, CpG2, and CpG12) and three BMAL1 CpGs (CpG2, CpG6, and CpG7). Road traffic noise was also associated with differential methylation of CRY1 and BMAL1 regions. In CRY1 CpG2 and CpG5 and in CLOCK CpG1, increasing levels of methylation tended to be associated with lower odds of breast cancer, with odds ratios (OR) of 0.88 (95% confidence interval (CI): 0.76–1.02), 0.84 (95% CI: 0.74–0.96), and 0.80 (95% CI: 0.68–0.94), respectively.
Conclusions
In summary, our data suggests that DNA hypomethylation in CRY1 could be part of a causal chain from road traffic noise to breast cancer. This is consistent with the hypothesis that disruption of the circadian rhythm, e.g., from road traffic noise exposure, increases the risk for breast cancer. Since no prior studies have explored this association, it is essential to replicate our results.
Iranian Nurses' Experiences with Interprofessional Collaboration in Oncology Care: A Qualitative Study
Authors: Seyyedin Seyyed Abolfazl Vaghar , Sadeghi-Akbari Ali , Nakhaei Maryam , Bahrami Mahnaz 
Published: May 2024

Abstract

Background
Interprofessional collaboration is essential for the provision of safe and comprehensive care to patients with complex health needs, particularly in oncology care settings. This qualitative study aimed to explore the experiences of oncology nurses in interprofessional collaboration.
Methods
This conventional content analysis study involved semi-structured interviews with 14 oncology nurses in Iran. Sampling was purposeful, and data were collected until saturation was achieved. Data were analyzed using the five steps of the Graneheim and Landman method. Trustworthiness was established using the Goba and Lincoln criteria.
Results
Five categories of interprofessional collaboration emerged from the experiences of oncology nurses: (1) Collaboration in the hands of physicians; (2) Collaboration as a forgotten issue; (3) Vague professional roles; (4) The role of a competent nurse in collaboration; and (5) Complex psychological state of oncology nurses.
Conclusions
Interprofessional collaboration is a complex, interactive, and communicative process that requires nurses to develop their professional roles and competencies. The nursing profession should take a leadership role in promoting interprofessional collaboration in oncology care. The findings of this study highlight the need to create opportunities for collaboration and to clarify professional roles to ensure that the common goal of providing high-quality care to oncology patients is achieved.
Interband Optical Absorption Coefficient of the DMS Ellipsoid Quantum Dot with Rashba Spin Orbit Interaction.
Authors: Babanlı A. M. , Balcı M. , Ovezov M. , Orazov G. , Sabyrov V. 
Published: May 2024

Abstract

In this paper, the effects of temperature, magnetic field, Rashba parameter, Mn atom impurity concentration and ellipsoid radius on the optical absorption coefficient of a dilute magnetic semiconductor ellipsoid quantum dot with spin-orbit Rashba interaction are investigated. Within the framework of the approximation of effective masses, the eigenvalue and the wave vector of the system are calculated. The obtained values are used to find the expression of the optical absorption coefficient for interband optical transitions. According to the results, temperature, magnetic field, Rashba parameter, Mn atom impurity concentration and ellipsoid radius change significantly affects the optical absorption coefficient.
Decoupling Control Strategy of Three-port DC-DC Converter based on Model Prediction
Authors: Wang Junrui , Qiao Xuanjing , Li Linhui , Wang Rui , Qin Hao 
Published: May 2024

Abstract

Due to the use of multi winding high-frequency isolation transformers in the three port isolated bidirectional DC-DC converter to achieve port isolation and power transmission, there is a power coupling problem between each port. This article proposes a Model Prediction Control (MPC) strategy to address this issue. Considering the control objectives for each port of the Three Active Bridge (TAB) DC-DC converter, a discrete predictive model of the TAB converter is established based on phase-shifting modulation and average model. The MPC problem is solved optimally and a predictive controller is designed with control accuracy to achieve decoupling control effect between each port. And the traditional single voltage closed-loop control, diagonal matrix decoupling control, and model predictive control proposed in this paper are compared through simulation. Finally, a TAB converter experimental platform is built based on the DSP control chip TMS320F28335. The experimental results are verified the effectiveness and superiority of the proposed method, as well as its faster dynamic characteristics and power decoupling ability between each port.
Clocking effect on the hydraulic performance and internal flow characteristics of a multistage centrifugal pump
Authors: xu tao , zhai lulu , Liang Weiwei , jin zheliang , jiang lei 
Published: May 2024

Abstract

Multistage centrifugal pumps are widely used in offshore oil production, the petrochemical and coal-chemical industries, and nuclear power fields for their advantages of large flow rate, high pressure, and excellent operation stability. The impellers in such pumps are often fixed with circumferential phase differences to avoid the synergistic excitation vibration of unbalanced mass in the same phase, which is the main cause of the clocking effect in multistage centrifugal pumps. In this study, the clocking effect on the hydraulic and internal flow characteristics of the first three stages of a 5-stage pump under the designed flow rate conditions are investigated. 9 test schemes were designed with the orthogonal design method， and internal flow characteristics measurements were done at 3 different positions of the pump. The results indicate that the clocking effect has minor impacts on the hydraulic performances, with a maximum reduction of lift coefficient of 0.275% and a maximum reduction in efficiency of 1.3%. The impeller pressure pulsation shows a maximum phase departure angle of 90 and a maximum dominant frequency departure phase of 59.17 Hz. The internal flow characteristics of a multistage pump have been improved. Comparing the results of 9 test schemes reveals adjusting the clocking positions of the impellers of the pump can obtain better internal flow characteristics of the whole pump．
Experimental and numerical investigation of cemented and non-cemented collapsible soils
Authors: Meftahi Maryam , LU Yong , Naeini Seyed Abolhasan , Schneider-Muntau Barbara 
Published: May 2024

Abstract

This paper presents findings from an experimental study examining the effects of colloidal nanosilica grouting on the behavior of collapsible soil under monotonic and cyclic loading conditions. Drained and undrained monotonic as well as cyclic triaxial tests were conducted on cemented and non-cemented soil specimens. Results indicated that the injection of colloidal nanosilica enhanced shear strength, reduced excess pore water pressure, and increased the brittleness index of cemented samples. In cyclic triaxial tests, non-cemented soil samples experienced liquefaction within initial cycles, while cemented samples remained stable until the 300th cycle. An elastoplastic constitutive model was employed to describe the mechanical behaviors of cemented and non-cemented soil specimens, showing good agreement between calculated and experimental results. However, slight discrepancies were observed in the trends of pore pressure and volume change for cemented soil. Factors such as incomplete saturation during sample preparation, hydraulic gradients along the length of the sample, colloidal nanosilica compressibility, and instrument sensitivity during data collection can lead to discrepancies between experimental and calculated values.
Reliability aware Task scheduler in Cloud Computing using improved AsynchronousAdvantage Actor critic(A3C) algorithm
Authors: Mangalampalli Sudheer , Karri Ganesh Reddy , Chakrabarti Prasun , chakrabarti Tulika , Margala Martin 
Published: May 2024

Abstract

Task Scheduling problem (TSP) in cloud computing is a critical aspect as diversified tasks from heterogeneous resources comes to cloud console. Mapping these diversified tasks to suitable virtual machines is challenge for the cloud service provider(CSP) to employ an efficient algorithm to tackle TSP. Ineffective scheduling lead to increase in makespan, failures which impacts reliability on CSP. Many authors developed various task scheduling mechanisms to tackle parameters makespan, execution time, energy consumption but very few authors addressed Rate of failures, reliability but there is need to optimize scheduling process in Cloud paradigm as it is a dynamic scenario. In this paper, a reliability aware task scheduler is formulated which calculates task priorities at task manager level to effectively schedule tasks. All priorities are fed to scheduler which is integrated with a deep Reinforcement learning model A3C which improved by adding RCNN to accelerate learning capacity and to extract features accurately mapping tasks to VMs according to their priorities. Simulations are carried out on Cloudsim using fabricated data distributions, real time worklogs. We evaluated our proposed RTSIA3C with baseline algorithms DQN, A2C. Results revealed that RTSIA3C outperformed over baseline approaches by minimizing makespan, rate of failures while improving reliability.
Asymptotic Properties of Conditional Value-at-risk Estimate for Asymptotic Negatively Associated Samples
Authors: jin rong , Tang Xufei , Chen Kan 
Published: May 2024

Abstract

In this article, we investigate the strong consistency of conditional value-at-risk (CVaR) estimatefor asymptotic negatively associated (ANA or $\rho^-$, for short) randoms samples under mild conditions. It is shown that the optimal rate can achievenearly $O (n^{-1/2})$ under some appropriate conditions. We also carry out some numerical simulations and a real data example to support our theoretical results based on finite samples.
MSC: 60G05; 62G20
Advancing Wine Fermentation: Extended Kalman Filter for Early Fault Detection
Authors: Lima Bruno , Luna Ricardo , Lima Daniel , Normey-Rico Julio , Perez-Correa Jose 
Published: May 2024

Abstract

This work proposes an Extended Kalman Filter (EKF) state estimation approach for early detection of stuck and sluggish wine fermentations. The goal is to provide accurate information to enologists during fermentation to facilitate timely intervention and decision making. The study investigates the sensitivity of the fermentation process to various factors such as model parameters and initial conditions, especially for unmeasured nitrogen. It also shows how the estimation depends on meaningful sugar measurements, which are not available during the lag phase of fermentation. According to Monte Carlo simulations, the estimation algorithm was able to predict 95% of the problematic fermentations within the first few days. When initial nitrogen measurements are taken into account, a reliable prediction is available on the first day in 80% of the cases, justifying the additional cost. These results support the use of advanced control and monitoring methods in wine production and other alcoholic fermentation processes.
Assessing the Factors Associated with the Respiratory Health of Children Working in Waste Management Activities: A Cross-Sectional Observational Study in Dhaka, Bangladesh
Authors: Bishwas Md. Sajan , Sehrin Farzana , Bayazid Anisur Rahman , Sara Hasna Hena , Quayyum Zahidul 
Published: May 2024

Abstract

Background: Children working in the waste management sector are vulnerable to respiratory health issues due to their high exposure to hazardous waste. This study aimed to examine the prevalence and determine the factors associated with respiratory symptoms among children involved in waste management activities in urban Dhaka, Bangladesh.
Methods: A cross-sectional observational study was conducted among 335 children aged 5-17 years working at Secondary Transfer Stations (STSs) in waste management activities in Dhaka city in July 2021. Data on sociodemographic characteristics, the nature of work, exposure to hazardous materials and conditions, smoking habits, and the knowledge of personal protective equipment (PPE) were collected using a structured questionnaire. Multistage cluster sampling and snowball techniques were used to recruit respondents. Bivariate and multivariate logistic regression were used to identify significant predictors of respiratory symptoms, with a p-value less than 0.05.
Results: The prevalence of respiratory symptoms among the children was 52.5%: dry cough (68.75%), followed by wheezing (13.64%), chest congestion (4.55%), and asthma (3.98%). Children working more than 60 hours per week were more likely to report respiratory symptoms (AOR: 3.41; 95% CI: 1.32-8.75). Additionally, children exposed to dust, fumes, and smoke have more than thirteen times the risk of respiratory symptoms than children without these exposures (AOR:13.5; 95% CI: 3.52-64.9). Belief in the effectiveness of protective masks was not significantly correlated with a lower incidence of respiratory symptoms.
Conclusion: This study highlights the high prevalence of respiratory symptoms among child waste workers in Dhaka City. This suggests that high levels of exposure to dust and long working hours increase the risk of respiratory symptoms among child waste workers in Dhaka City. Improved waste management practices, reduced working hours, effective use of PPE to reduce dust and fume exposure, and targeted health policies could mitigate respiratory symptoms of children working in the waste management sector.
Longitudinal associations of plasma amino acid levels with recovery from malarial coma
Authors: Granger Donald L. , Ansong Daniel , Agbenyega Tsiri , Liddle Melinda S. , Brinton Benjamin A. , Hale Devon C. , Lopansri Bert K. , Reithinger Richard , Bisanzio Donal 
Published: May 2024

Abstract

Background
Disordered amino acid metabolism is observed in cerebral malaria (CM). We sought to determine whether abnormal amino acid concentrations were associated with level of consciousness in children recovering from coma. We quantified 21 amino acids and coma scores longitudinally and analyzed data for associations.
Methods
In a prospective observational study, we enrolled 42 children with CM. We measured amino acid levels at entry and at frequent intervals thereafter and assessed consciousness by Blantyre Coma Scores (BCS). Thirty-six healthy children served as controls for in-country normal amino acid ranges. We employed logistic regression using a generalized linear mixed-effects model to assess associations between out-of-range amino acid levels and BCS.
Results
At entry 16/21 amino acid levels were out-of-range. Longitudinal analysis revealed 10/21 out-of-range amino acids were significantly associated with BCS. Elevated phenylalanine levels showed the highest association with low BCS. This finding held when out-of-normal-range data were analyzed at each sampling time.
Discussion
We provide longitudinal data for associations between abnormal amino acid levels and recovery from CM. Of 10 amino acids significantly associated with BCS, we propose that elevated phenylalanine may be a surrogate for impaired clearance of ether lipid mediators of inflammation contributing to CM pathogenesis.
Exploring the Potential of Oryza sativa derived Candidate miRNAs to Target Rice Tungro Bacilliform Virus (RTBV) Genome
Authors: Awan Mudassar Fareed , Suddal Tauheed , Bibi Rozina , Iqbal Muhammad Shahzad , Irshad Asma , Ahsan Muhammad Umair , Yahya Muhammad , Rab Sofia Obaidur 
Published: May 2024

Abstract

Background: Rice tungro disease (RTD) poses a serious threat to global rice cultivation, primarily afflicted by Rice tungro bacilliform virus (RTBV) and Rice tungro spherical virus (RTSV) strains. This challenge demands innovative approaches presenting a computational procedure to identify potential candidate miRNAs from Oryza sativa based mirBase repository that can predict target sites in RTBV and RTSV genome.
Results: Through our insilico based analysis utilizing different target prediction algorithms, five potential rice derived miRNAs were screened with maximum potential to target the RTBV genome. The candidate miRNAs include osa-miR166a-5p, osa-miR156g-3p, osa-miR413, osa-miR426, and osa-miR160a-5p. Additionally, seven miRNAs were predicted to explore their potential to target the RTSV genome i.e., osa-miR530-3p, osa-miR414, osa-miR390-5p, osa-miR156h-3p, osa-miR164b, osa-miR166c-3p, and osa-miR160a-5p. These miRNAs underwent effective evaluation, including free energy estimation and secondary structures were determined to ensure their efficacy in genome silencing. Moreover, site conservation analysis revealed conserved domains inside target sites. The screened miRNAs underscoring their immense potential to trigger robust mRNA intervention in viral genome. Furthermore, phylogenetic trees were also constructed to interpret the evolutionary relationships among closely related species providing valuable insights into the evolutionary standing of RTBV and RTSV. This study presents a holistic computational framework exploring potential candidate miRNAs derived from Oryza sativa with good capability to target RTBV and RTSV genomes.
Conclusion: These findings hold considerable promise for the development of RNA-based strategies aimed at mitigating the impact of rice tungro disease, thereby contributing to sustainable rice production and global food security.
The ROS mediates MCUb in mitochondria-regulated apoptosis of TM4 cells induced by titanium dioxide nanoparticles
Authors: Sun# Chenhao , Wang# Qianqian , Dong Ruoyun , Lei Yuzhu , Hu Yunhua , Yan Yizhong , Song Guanling 
Published: May 2024

Abstract

Titanium dioxide nanoparticles (TiO2 NPs) can cause mitochondrial apoptosis of TM4 cells, but the mechanisms behind this process are not yet clear. The aim of this study was to evaluate if the accumulation of ROS caused by TiO2 NPs inhibits MCUb expression, causing mitochondrial calcium overload and ultimately leading to cell apoptosis through the mitochondrial pathway. TM4 cells were exposed to different concentrations of TiO2 NPs (0, 25, 50, 75, 100 µg/mL) for 24 hours. We measured the cell viability, ROS level, MCUb and VDAC1 expression, mitochondrial and cytoplasmic Ca2+ level, MMP, apoptosis rate, and the key proteins related to apoptosis via the mitochondria pathway (Bcl-2, Bax, Caspase 3, Caspase 9, p53 and Cyt c). The effect of NAC on MCUb expression, calcium homeostasis, and cell apoptosis were also measured in this study. The results showed that compared to TM4 cells in control group, TiO2 NPs significantly increased ROS level, downregulated MCUb expression, prompted the Ca2+ level in mitochondria and cytoplasm, and enhanced the mitochondria-regulated apoptosis, starting from the 50 µg/mL TiO2 NPs group. However, NAC significantly increased the expression of MCUb, attenuated Ca2+ level in mitochondria and cytoplasm, and reduced the mitochondria-related apoptosis of TM4 cells compared with those in TiO2 NPs group cells. In conclusion, TiO2 NPs induced ROS accumulation which inhibits the expression of MCUb. The deceased MCUb level leads to Ca2+ overload in mitochondria, which causes TM4 cells apoptosis through the mitochondrial pathway. The results of this research elucidate the role of ROS in regulating mitochondrial calcium overload through MCUb for the first time when TM4 cells were exposed to TiO2 NPs, and the results also supplement the molecular mechanism of cell apoptosis induced by TiO2 NPs.