bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients—a randomized multicentre pilot study (PLTS-1)
Authors: Bartoszko Justyna , Peer Miki , Grewal Deep , Ansari Saba , Callum Jeannie , Karkouti Keyvan 
Published: June 2024

Abstract
Background
Platelets stored at 1–6 °C are hypothesized to be more hemostatically active than standard room temperature platelets (RTP) stored at 20–24 °C. Recent studies suggest converting RTP to cold-stored platelets (Delayed Cold-Stored Platelets, DCSP) may be an important way of extending platelet lifespan and increasing platelet supply while also activating and priming platelets for the treatment of acute bleeding. However, there is little clinical trial data supporting the efficacy and safety of DCSP compared to standard RTP.

Methods
This protocol details the design of a multicentre, two-arm, parallel-group, randomized, active-control, blinded, internal pilot trial to be conducted at two cardiac surgery centers in Canada. The study will randomize 50 adult (≥ 18 years old) patients undergoing at least moderately complex cardiac surgery with cardiopulmonary bypass and requiring platelet transfusion to receive either RTP as per standard of care (control group) or DCSP (intervention group). Patients randomized to the intervention group will receive ABO-identical, buffy-coat, pathogen-reduced, platelets in platelet additive solution maintained at 22 °C for up to 4 days then placed at 4 °C for a minimum of 24 h, with expiration at 14 days after collection. The duration of the intervention is from the termination of cardiopulmonary bypass to 24 h after, with a maximum of two doses of DCSP. Thereafter, all patients will receive RTP. The aim of this pilot is to assess the feasibility of a future RCT comparing the hemostatic effectiveness of DCSP to RTP (defined as the total number of allogeneic blood products transfused within 24 h after CPB) as well as safety. Specifically, the feasibility objectives of this pilot study are to determine (1) recruitment of ≥ 15% eligible patients per center per month); (2) appropriate platelet product available for ≥ 90% of patients randomized to the cold-stored platelet group; (3) Adherence to randomization assignment (> 90% of patients administered assigned product).

Discussion
DCSP represents a promising logistical solution to address platelet supply shortages and a potentially more efficacious option for the management of active bleeding. No prospective clinical studies on this topic have been conducted. This proposed internal pilot study will assess the feasibility of a larger definitive study.

Trial registration
NCT 06147531 (clinicaltrials.gov).
A review on the anti-parasitic activity of ruthenium compounds
Authors: Chakraborty Shibam , Ghosh Sumit , Dalui Shauryabrota , Dey Avijit 
Published: June 2024

Abstract
Background
There are many infectious diseases in the world caused by parasites. Among them, toxoplasmosis, American trypanosomiasis, African trypanosomiasis, leishmaniasis, neosporosis and malaria are more common and contribute to a majority of the affected individuals.

Main body
Due to extensive use of antibiotics, antibiotic resistant strain of the parasites has developed. So, we need to develop a new metal ligand complexes which have many configurations, can overcome this drug resistance and also show significant results in elimination of the parasites. A series of anti-parasitic drugs have been formulated and tested for its activity. In this review, we have tried to see the interaction of different ruthenium drugs (arene ruthenium complex, ruthenium clotrimazole complex, etc.) on different parasites associated with the aforementioned diseases.

Conclusion
Combination of ruthenium to any organic ligand shows synergistic effects against parasite either by overcoming the drug resistance of the parasite or by binding with new targets due to the presence of ruthenium ion. The multiple modes of action generate an effective drug exhibiting anti-parasitic activity at low concentration.

Graphical abstract
Clinical outcomes of post-placental insertion of Copper T380A and Multiload 375 contraceptive devices during cesarean section: a randomized clinical trial
Authors: Awaga Hatem Abo Elftooh , Abdel-Mawjud Mahmoud Ahmad , Ismail Mohammed Samir , Ahmed Salah Roshdy 
Published: June 2024

Abstract
Background
To compare two types of intrauterine devices, namely Cu T380A IUD and Multiload 375 IUD, inserted immediately post-placental during cesarean section, with regard to expulsion rates and side effects.

Methods
A randomized comparative clinical trial was carried out over 200 patients with 100 patients in each group. Transabdominal ultrasonography (US) was done on all patients before discharge to ensure the adequate position of the IUD in addition to casco speculum examination to assess the IUD threads, and then women were requested to attend a follow-up appointment at 6 weeks after delivery; gynecological examinations in addition to transvaginal sonography were done to measure the top-fundal distance that reflects the position of the IUD. The participants were instructed to report the pattern of bleeding during the puerperium, fever, or vaginal discharge.

Results
The ultrasonographic assessment of IUD position before patient discharge (1st assessment) revealed that 18% of Cu T380A IUD users were displaced in comparison to 24% of Multiload 375 IUD, and such difference between both groups was not statistically significant (P = 0.3); furthermore, the ultrasonographic assessment of IUD position after 6 weeks (2nd assessment) revealed that 19% of Cu T380A IUD users were displaced in comparison to 30% of Multiload 375 IUD, and such difference between both groups was statistically significant (P = 0.047). In addition, none of the included patients in both groups suffered from fever after IUD insertion.

Conclusion
The present study demonstrated that post-placental insertion of Multiload 375 IUCD results in significantly higher displacement compared to post-placental insertion of Cu T380A IUCD, as well as significantly more bleeding problems with Cu T380A IUCD as compared with Multiload 375 IUCD.

Trial registration
The study was registered prospectively on clinical trial.gov with trial registeration number NCT05624411 (Registered 22-October-2022, https://clinicaltrials.gov/study/NCT05624411).
Bile level of cytokeratin 7 as a diagnostic marker for cholangiocarcinoma: a case-control study in Egyptian patients
Authors: Nada Ali , Alkhatib Alzhraa , Abdelmalik Fady , El-Abd Mona , Elabd Naglaa S. , Abdel-Latif Hossam El-Din 
Published: June 2024

Abstract
Background
Cholangiocarcinoma (CCA) is an aggressive malignancy with a poor prognosis of less than 20% five-year survival rate. Early diagnosis is typically challenging due to asymptomatic characteristics at the earliest stages of the disease. This study aims to assess the potential utility of cytokeratin 7 (CK7) as a CCA diagnostic biomarker in bile. In total, 100 participants were included in this case-control study. Moreover, Group I had 30 CCA patients with malignant obstruction, and Group II had 20 patients with malignant biliary obstruction other than CCA formed. Group III included 20 patients with benign biliary obstruction, and 30 individuals undergoing cholecystectomy with no evidence of biliary obstruction made up the control group (Group IV). Bile samples were collected during endoscopic retrograde cholangiopancreatography or cholecystectomy for the control group. The CK7 levels in bile samples were measured using the enzyme-linked immunosorbent assay.
Results
The bile level of CK7 was significantly higher in cholangiocarcinoma patients (1555.4 ± 302.7 pg/mL) than those of the patients with malignancies other than CCA (581.9 ± 227.5 pg/mL), patients with benign obstruction (439.5 ± 255.7 pg/mL), and the control group (53 ± 26.4 pg/mL) (p value < 0.001). Furthermore, CK7 was significantly higher in CCA patients than in those with other malignancies (p value < 0.001). Patients with CCA with hilar lesions had the highest values compared to those with distal lesions. ROC curve analysis revealed that bile CK7 at a cut point of >1030 pg/mL yielded an area under a curve of 1 (95% CI: 1.000–1.000) in differentiating CCA from other groups.
Conclusion
The bile level of CK7 demonstrates outstanding performance that could help in diagnosing CCA.
An energy-aware cluster-based routing in the Internet of things using particle swarm optimization algorithm and fuzzy clustering
Authors: Lei Chang 
Published: June 2024

AbstractThe effectiveness and longevity of IoT infrastructures heavily depend on the limitations posed by communication, multi-hop data transfers, and the inherent difficulties of wireless links. In dealing with these challenges, routing, and data transmission procedures are critical. Among the fundamental concerns are the attainment of energy efficiency and an ideal distribution of loads among sensing devices, given the restricted energy resources at the disposal of IoT devices. To meet these challenges, the present research suggests a novel hybrid energy-aware IoT routing approach that mixes the Particle Swarm Optimization (PSO) algorithm and fuzzy clustering. The approach begins with a fuzzy clustering algorithm to initially group sensor nodes by their geographical location and assign them to clusters determined by a certain probability. The proposed method includes a fitness function considering energy consumption and distance factors. This feature guides the optimization process and aims to balance energy efficiency and data transmission distance. The hierarchical topology uses the advanced PSO algorithm to identify the cluster head nodes. The MATLAB simulator shows that our method outperforms previous approaches. Various metrics have demonstrated significant improvements over DEEC and LEACH. The method reduces energy consumption by 52% and 16%, improves throughput by 112% and 10%, increases packet delivery rates by 83% and 15%, and extends the network lifespan by 48% and 27%, respectively, compared to DEEC and LEACH approaches.
Importance of Adequate Surgical Local Control in Fusion-Negative Para-Testicular Rhabdomyosarcoma: Data From the Cooperative Weichteilsarkom Studiengruppe Trials (CWS-96 and CWS-2002P) and the European Soft Tissue Sarcoma Registry (SoTiSaR)
Authors: Martynov Illya , Sparber-Sauer Monika , Heinz Amadeus , Vokuhl M. Christian , Ebinger Martin , Gesche Jens , Münter Marc , Koscielniak Ewa , Fuchs Jörg , Seitz Guido ,   Cooperative Soft Tissue Sarcoma Study Group
Published: June 2024

Abstract
Background
This study aimed to assess the impact that the quality of primary and subsequent surgeries has on the survival of patients with para-testicular rhabdomyosarcoma (PTRMS).

Methods
Patients with localized (IRS I–III) and metastatic (IRS IV) PTRMS were enrolled in the two Cooperative Weichteilsarkom Studiengruppe (CWS) trials (CWS-96, CWS-2002P) and the Soft Tissue Sarcoma Registry (SoTiSaR).

Results
Among 196 patients (median age, 8.4 years), 106 (54.1%) had primary complete resection. Image-defined lymph node (LN) disease was detected in 21 (11.5%) patients in the localized cohort and 12 (92.3%) patients in the metastatic cohort. The 5-year event-free survival (EFS) and overall survival (OS) were respectively 87.3% and 94.0% for the patients with localized PTRMS and 46.2% and 42.2% for the patients with metastatic PTRMS. Protocol violations during the primary surgery (PV-PS) were observed in 70 (42%) of the IRS I–III patients. This resulted in higher rates of R1/R2 resections (n = 53 [76%] vs n = 20 [21%]; p < 0.001) with a need for pretreatment re-excision (PRE) (n = 50 [83%] vs n = 10 [17%]; p < 0.001) compared with the patients undergoing correct primary surgery. Protocol violations during PRE occurred for 13 (20%) patients. Although PV-PS did not influence the 5-year EFS or OS in the localized PTRMS cohort, the unadjusted log-rank test showed that R status after PRE is a prognostic factor for 5-year OS (R1 vs R0 [81.8% vs 97.6%]; p = 0.02).

Conclusions
The quality of surgical local control in PTRMS is unsatisfactory. Emphasis should be placed on evaluating the resection status after PRE in further clinical trials.
Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer
Authors: Miller Phoebe N. , Romero-Hernandez Fernanda , Calthorpe Lucia , Wang Jaeyun Jane , Kim Sunhee S. , Corvera Carlos U. , Hirose Kenzo , Kirkwood Kimberly S. , Hirose Ryutaro , Maker Ajay V. , Alseidi Adnan A. , Adam Mohamed A. , Kim Grace E. , Tempero Margaret A. , Ko Andrew H. , Nakakura Eric K. 
Published: June 2024

Abstract
Background
In 2023 alone, it’s estimated that over 64,000 patients will be diagnosed with PDAC and more than 50,000 patients will die of the disease. Current guidelines recommend neoadjuvant therapy for patients with borderline resectable and locally advanced PDAC, and data is emerging on its role in resectable disease. Neoadjuvant chemotherapy may increase the number of patients able to receive complete chemotherapy regimens, increase the rate of microscopically tumor-free resection (R0) margin, and aide in identifying unfavorable tumor biology. To date, this is the largest study to examine surgical outcomes after long-duration neoadjuvant chemotherapy for PDAC.

Methods
Retrospective analysis of single-institution data.

Results
The routine use of long-duration therapy in our study (median cycles: FOLFIRINOX = 10; gemcitabine-based = 7) is unique. The majority (85%) of patients received FOLFIRINOX without radiation therapy; the R0 resection rate was 76%. Median OS was 41 months and did not differ significantly among patients with resectable, borderline-resectable, or locally advanced disease.

Conclusions
This study demonstrates that in patients who undergo surgical resection after receipt of long-duration neoadjuvant FOLFIRINOX therapy alone, survival outcomes are similar regardless of pretreatment resectability status and that favorable surgical outcomes can be attained.
Preoperative COVID-19 and Postoperative Mortality in Cancer Surgery: A South Korean Nationwide Study
Authors: Ju Jae-Woo , Yoon Soo-Hyuk , Oh Tak Kyu , Lee Ho-Jin 
Published: June 2024

Abstract
Background
We evaluated the impact of preoperative COVID-19 on early postoperative mortality in patients undergoing time-sensitive cancer surgery.

Methods
This retrospective, nationwide cohort study included adult patients who underwent various cancer (thyroid, breast, stomach, colorectal, hepatobiliary, genitourinary, lung, and multiple cancer) surgeries under general anesthesia in South Korea in 2022. Patients were grouped according to the duration from the date of COVID-19 confirmation to the date of surgery (0–2 weeks, 3–4 weeks, 5–6 weeks, and ≥7 weeks). Patients without preoperative COVID-19 also were included. Multivariable logistic regression analysis with Firth correction was performed to investigate the association between preoperative COVID-19 and 30-day and 90-day postoperative mortality. The covariates encompassed sociodemographic factors, the type of surgery, and vaccination status in addition to the aforementioned groups.

Results
Of the 99,555 patients analyzed, 30,933 (31.1%) were preoperatively diagnosed with COVID-19. Thirty-day mortality was increased in those who underwent surgery within 0–2 weeks after diagnosis of COVID-19 (adjusted odds ratio [OR], 1.47; 95% confidence interval [CI], 1.02–2.12; P = 0.038); beyond 2 weeks, there was no significant increase in mortality. A similar pattern was observed for 90-day mortality. Full vaccination against COVID-19 was associated with reduced 30-day (OR 0.38; 95% CI 0.29–0.50; P < 0.001) and 90-day (OR 0.39; 95% CI 0.33–0.46; P < 0.001) mortality.

Conclusions
Cancer surgery within 2 weeks of COVID-19 diagnosis was associated with increased early postoperative mortality. These findings support current guidelines that recommend postponing elective surgery for at least 2 weeks after the diagnosis of COVID-19.
Health benefits of exercise and dietary interventions for patients with psoriasis – a literature review
Authors: Staniszewska Izabela 
Published: June 2024

Introduction: Psoriasis is a prevalent chronic inflammatory systemic disease that can manifest in a variety of clinical manifestations. Psoriasis was thought to only affect the skin. Recent findings from dermatologic, rheumatologic, and cardiologic research indicate that it is a systemic disease, henceforth referred to as psoriatic disease.
Purpose of work: Collecting information on the benefits of physical activity and diet modifications in patients with psoriasis on aspects such as metabolic syndrome, cardiovascular risk, mental health, and general well-being.
Summary: Psoriasis is a disease that affects many areas of life. Physical activity improves the body weight, mental health, and cardiovascular risk of patients with psoriasis. Engaging in physical activity may reduce the probability of developing psoriasis and may also ameliorate its course. The Mediterranean diet, ketogenic diet, probiotics, and alcohol withdrawal may also alleviate the course of psoriasis. It is noteworthy to mention the potential limitations that may arise in the context of this disease, including embarrassment resulting from skin lesions and joint discomfort resulting from psoriatic arthritis. Sports training ought to be customized for each patient, taking into account their limitations and preferences.
Pre-service teachers’ reflections on their participation in 1:1 laptop programs
Authors: Walker Rebecca Maria , Blackley Susan Ellen 
Published: June 2024

A number of government and non-government schools have implemented a one-laptopper-student (1:1) policy. Whilst there was initial interest in the implementation of these programs, little has been done to track the uptake of digital learning technologies afforded by access to the laptops. This study examined tertiary students’ reflections on their experiences with 1:1 laptop programs after graduating from secondary school and at the commencement of their Bachelor of Education course. It is an extension of a previous study conducted by the researchers (authors, 2015) that presented findings about teachers’ use of laptops in 1:1 laptop program schools. The objectives of this second-phase research were to: 1) Capture recollections of the students’ experience of 1:1 laptop programs, 2) Categorise these recollections into positive and negative experiences, 3) Investigate the impact of 1:1 laptop programs on students’ perceptions of teaching with ICTs and their personal learning at University.
The ethical considerations of using social media in educational environments
Authors: Cameron Leanne , Tanti Miriam , Mahoney Kim 
Published: June 2024

Students in an undergraduate pre-service teacher education course were asked to utilise Twitter to access the professional educational community. Their tweets were to be used to promote the sharing of educational resources and establish a local supportive community of practice, to keep others informed of their teaching experiences and provide a vehicle for support and advice, both inside and outside the university. The ethical issues in relation to the use of social media in educational environments were wide-reaching and complex. This paper reports on a pilot study that begins an investigation on the practices of university students using social media in their studies. The ultimate aim of the project is to develop workable guidelines on the ethical use and practice of social media use in university education.
Using Learning Design to Unleash the Power of Learning Analytics
Authors: Atkinson Simon Paul 
Published: June 2024

New learning technologies require designers and faculty to take a fresh approach to the design of the learner experience. Adaptive learning, and responsive and predicative learning systems, are emerging with advances in learning analytics. This process of collecting, measuring, analysing and reporting data has the intention of optimising the student learning experience itself and/or the environment in which the experience of learning occurs. However, it is suggested here that no matter how sophisticated the learning analytics platforms, algorithms and user interfaces may become, it is the fundamentals of the learning design, exercised by individual learning designers and faculty, that will ensure that technology solutions will deliver significant and sustainable benefits. This paper argues that effective learning analytics is contingent on well structured and effectively mapped learning designs.
Assessment of antiproliferative activity of green-synthesized nickel oxide nanoparticles against glioblastoma cells using Terminalia chebula
Authors: Long Sui , Hui Lu , Yanli Dou , Dongdong Zhang , Feixiong Du , Weibing Wang 
Published: June 2024

Abstract
The present study investigates the effect of nickel oxide nanoparticles (NiO-NPs) on C6 glioma cells and develops a method for preparing NiO. Plant-based materials (leaf extract) can produce NPs efficiently and economically. Therefore, we developed NiO-NPs from Terminalia chebula leaf extract to reduce C6 glioblastoma cell proliferation. The structural, optical, and antimicrobial properties of NiO-NPs were investigated. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays, Acridine orange/ethidium bromide dual staining, Hoechst 33342, and Rh123 staining were used to evaluate nuclear changes and mitochondrial membrane potential (MMP) in C6 glioblastoma cells. X-ray diffraction analyses revealed the cubic structures of the synthesized NiO-NPs, field emission scanning electron microscope analysis revealed polygonal NiO-NPs and an energy-dispersive X-ray spectrometer confirmed the high purity of the synthesized NiO-NPs. V. cholera, S. pneumonia, S. aureus, B. subtilis, P. aeruginosa, K. pneumonia, and C. albicans were sensitive to NiO-NPs. When NiO-NPs were applied at lower concentrations to rat glioblastoma C6 cells, they dose-dependently inhibited viability and induced apoptosis. Our findings show that NiO-NPs exhibit altered MMP and nuclear integrity. In this study, NiO-NPs were synthesized using T. chebula leaf extract, which has antiproliferative properties, and NiO-NPs increased cell cytotoxicity in C6 cells. Further exploration of NiO-NPs in glioblastoma animal models should be investigated.
Detecting treatment interference under K-nearest-neighbors interference
Authors: Alzubaidi Samirah H. , Higgins Michael J. 
Published: June 2024

AbstractWe propose a model of treatment interference where the response of a unit depends only on its treatment status and the statuses of units within its K-neighborhood. Current methods for detecting interference include carefully designed randomized experiments and conditional randomization tests on a set of focal units. We give guidance on how to choose focal units under this model of interference. We then conduct a simulation study to evaluate the efficacy of existing methods for detecting network interference. We show that this choice of focal units leads to powerful tests of treatment interference that outperform current experimental methods.