bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blossoming of the Pleistocene volcanism in the Ecuadorian Andes: a review based on new and recent geochronological data
Authors: Santamaria Santiago David , Bablon Mathilde , Quidelleur Xavier , Samaniego Pablo , Pennec Jean-Luc Le , Hidalgo Silvana , Liorzou Céline 
Published: May 2024

Abstract

The Ecuadorian arc is composed of an unusually high number of volcanoes organized as along-arc alignments and across-arc clusters, over a relatively small area. Although several geochronological studies were carried out in the past three decades, the eruptive history of the central zone of the arc remained poorly documented, preventing the analyses of volcanism initiation of the whole arc. In this study, we present new K-Ar ages obtained from this central area, referred as the Quito segment. These results were then included in an updated comprehensive geochronological database including about 250 ages, allowing us to describe, at the arc scale, the spatial and temporal development of Quaternary volcanic activity in Ecuador. About eighty Quaternary volcanoes are identified in the Ecuadorian Andes, amounting to 45 volcanic complexes with radiometric ages and/or identified as active or potentially active. The volcanic arc developed in three stages marked by increases in the total number of active volcanoes. During the oldest Plio-Early Pleistocene stage, the documented volcanic activity was mostly concentrated in the Eastern Cordillera of the Quito segment, with minor effusive eruptions in the southern Back-Arc. Since ~ 1.4 Ma, the activity spread to the surroundings of the Quito segment and new edifices also appeared in the Western Cordillera and the Inter-Andean Valley. Towards the end of this intermediate stage (i.e., ~ 800 ka), volcanism occurred in isolated areas to the north and south of the Inter-Andean Valley. Finally, the late and current stage was characterized by a remarkable increase in volcanic activity since ~ 600 ka. Approximately 50 volcanoes were active during this stage. The spatial distribution of the Ecuadorian arc volcanism seems to be guided by deep mechanisms and old crustal tectonic structures from the Western Cordillera, whereas the neotectonics seem to influence the development of stratovolcanoes. In addition, we note that the spatial and temporal evolution of volcanism highlights the influence of the Carnegie Ridge and the thermal regime anomaly of the young Nazca crust on the increase of volcanic activity in Ecuador.
Chitooligosaccharide Inhabits Migration of Pancreatic Cancer Cells by Regulating Epithelial– Mesenchymal Transition
Authors: Liu Xu , Liu Han , Ding Siyuan , Lyu Weiyan , Lu Shengyan 
Published: May 2024

Abstract

Background
Studies have confirmed that chito-oligosaccharide (COS) has antitumour effect, but research on its effect on pancreatic cancer (PC) remains limited and unclear. This study aimed to explore effects of COS on PC cells.
Method
We used different concentrations of COS to treat PC cells and conducted Cell Counting Kit-8, wound-healing, and transwell assays to evaluate the proliferation, invasion, and migration ability of PC cells, respectively. Western blotting was conducted to assess the expression levels of epithelial–mesenchymal transition (EMT) related markers.
Result
The proliferation, invasion, and migration ability of PC cells (PANC-1 and MIAPaCa-2) gradually decreased in a manner dependent on COS concentration. COS at 10 mg/mL exerted the strongest inhibitory effect on the two PC cell lines. At 10 mg/mL, the proliferative activity was 60.61% ± 5.25% and 64.02% ± 4.96%, respectively; the invasive ability was (18.67 ± 4.416) and (31.33 ± 3.162), respectively; and the cell-migration ability was 26.83% ± 0.442% and 17.66% ± 0.647%, respectively. The expression levels of N-cadherin and vimentin were significantly downregulated in PANC-1 cells (0.198 ± 0.047 and 0.225 ± 0.038, respectively) and MIAPaCa-2 cells (0.214 ± 0.094 and 0.214 ± 0.094, respectively) at 10 mg/mL, respectively. Conversely, E-cadherin was upregulated (0.460 ± 0.037 and 0.491 ± 0.047, respectively). Compared with control group, the differences were statistically significant.
Conclusion
The upregulation of E-cadherin and the downregulation of vimentin and N-cadherin suggested that the specific mechanism of COS in PC may be related to EMT. This study provided a new direction for PC treatment.
Early Intervention of 5% Albumin shown Superior Control of Vascular Integrity and Function Compared to Ringer’s Lactate in Hospitalized Adult with Grade I &amp; II Dengue Hemorrhagic Fever: A Multicenter Randomized Controlled Trial in Indonesia
Authors: Bur Rika , Suwarto Suhendro , Pohan Herdiman T , Prihartono Joedo , Harahap Alida Roswita , Dewi Beti Ernawati , Sadikin Mohamad , Rachman Andhika , Yusuf Hadi 
Published: May 2024

Abstract

Background
Dengue virus remains a major public health problem with one of the hallmark pathologies is the vascular leakage caused by endothelial dysfunction which can lead to Dengue Hemorrhagic Fever (DHF) manifestation. In the status quo, no specific therapy has been discovered but rather heavily relies on judicious and frequent monitoring of intravenous fluids administration. The current guideline has discussed the roles of fluid therapy during the Dengue Shock Syndrome (DSS) stage, however, administration of early fluid intervention for DHF grade I and II remains uncharted territory. In addition, the choice and timing of colloid administration remains underexplored. As one of the widely available colloids, 5% albumin has known physiological properties that potentially minimize plasma leakage. Therefore, this study aimed to evaluate the benefit of early intervention of 5% albumin in adults with DHF in the hope of preventing the lethal progression to DSS and further, shorten the length of stay (LOS) for patients.
Methods
We conducted a multicenter, open-labeled, randomized controlled trial in Jakarta and Banten to compare the effect of early intervention with 5% albumin in adult patients with DHF compared to Ringer’s Lactate (RL). Statistical analyses were conducted using unpaired t-test and Mann-Whitney for normally and abnormally distributed data respectively.
Results
Adult patients with a diagnosis of DHF grade I and II that being hospitalized to receive the early intervention of 5% albumin had significantly lower levels of hemoconcentration 4, 12, and 24 hours (p = 0.002, 0.001, 0.003, respectively), higher platelet counts 4 hours (p = 0.036), higher serum albumin levels 48 hours (p = 0.036), lower proteinuria 24 and 48 hours post-albumin administration (p < 0.001, < 0.001, respectively), and shorter LOS (p < 0.001) when compared to the RL group.
Conclusion
Early intervention of 5% albumin showed better control on vascular integrity and function compared to ringer lactate in hospitalized adults with grade I & II DHF, thus halting the progression of DHF into DSS and other related complications which leads to faster recovery and shorter length of stay.
Trial Registration:
The study was registered to www.clinicaltrial.gov with trial registration number NCT04076254, and registration date October 31st 2016.
Proof of the association between adenovirus infection and appendicitis in children through pathological evidence
Authors: Lin Lung-Huang , Huang Chi-Jung , Lo Cheng-Yu , Lee Yu-Hsien 
Published: May 2024

Abstract

Appendicitis is inflammation and swelling of the appendix that can occur at any age. It can be caused by fecalith blocking the appendix entrance and has been associated with lamina propria thickening due to infection. Some reports have observed a relation between appendicitis and hyperplastic lymphoid tissue, which might be caused by infections like adenovirus, while others have linked adenovirus infection and appendicitis in children. This study retrospectively analyzed appendix tissue pathology from children who underwent appendectomy and more directly investigate the relation between adenovirus infection and appendicitis. We included 120 children under age 18 who underwent appendectomy in patients with appendicitis at Cathay General Hospital between January 2016 and January 2021. Adenovirus immunohistochemistry (IHC) and quantitative polymerase chain reaction (qPCR) were analyzed to determine the positive rate of adenovirus in appendicitis. Thirty-one cases (25.8%) were positive for anti-adenovirus antibody IHC. qPCR was positive for adenovirus in 42 cases (35%). Eleven (9.2%) tested positive by both IHC and qPCR. Our pathological evidence directly confirms a relation between adenovirus infection and appendicitis. IHC and qPCR analyses confirmed evidence of adenovirus infection in patients with appendicitis. qPCR is as useful and reliable as IHC, and more sensitive, for diagnosing adenovirus in appendicitis.
Modified Bergman spaces on the unit ball of $\mathbb C^n$ and applications
Authors: Amor Hajer Ben , Ghiloufi Noureddine 
Published: May 2024

Abstract

In this paper, we introduce new spaces $\mathcal A^p_{a,b}(\mathbb B_n)$ of holomorphic functions on the unit ball $\mathbb{B}_{n}$ of $\mathbb{C}^{n}$ generalizing the classical Bergman spaces. We start by giving some properties of these spaces and the determination of the reproducing kernel in the case $p=2$, then we study the boundedness of the Bergman projections. Using the Berezin transform, a type of Bergman-Poincar\'e metric with an application on the space of bounded mean oscillation functions are given at the end of the paper.
2010 Mathematics Subject Classification. 47G10, 32A25, 32A36, 32A37.
Liquefaction Subsidence and Cyclic Loading as Design Factors for Stable Foundations in Deltaic Soils
Authors: Kennedy Charles , Udo Essien 
Published: May 2024

Abstract

The presence of high fines percentages in Deltaic soils near the surface necessitates consideration of the soil's engineering properties when designing structures for this environment. This study examines the fines content and engineering properties of soil in deltaic settings to ascertain potential risks associated with liquefaction and settlement issues. The findings reveal that the deeper layers of deltaic soil have a reduced plasticity and liquid limit, providing a more stable foundation with a lower susceptibility to liquefaction. Thus, deep foundations may be required in order to ensure the structural integrity of buildings during periods of cyclic loading and stress. Comprehensive foundation designs, such as the use of piles or caissons, are recommended in order to penetrate beyond the fine-grained surface layer. Moreover, particular attention should also be paid to soil improvement techniques, including compaction, grafting, or reinforcement, which can increase soil properties and therefore the load-bearing capacity and resistance to settlement. Ultimately, it is essential to comprehend the technical properties of soil to implement appropriate foundation designs. The higher concentrations of fines at the surface could lead to liquefaction and potentially reduced load capacities. Hence, deeper soil layers should be used as they present greater rigidity and improved fluid retention, helping to provide safer and more durable structures.
Study on the Ecological Environment quality and its driving factors of the Spatial Transformation of Production-Living-Ecological Space in Baishan City
Authors: huang jintao , Zhang Yichen , Zhang Jiquan , Qi Jiawei , Liu Peng 
Published: May 2024

Abstract

In order to strengthen the overall planning and coordination of urban construction and ecological space in Baishan City, we should formulate a scientific land type planning of Production-Living-Ecological Space (PLES). In this paper, land use dynamic attitude model, land use transfer matrix, land use function center of gravity transfer model, eco-environmental quality index(EEQI) and geographic detector model are used to discuss the spatio-temporal evolution of ternary spatial types in Baishan City from 2000 to 2020. Spatio-temporal evolution of EEQI and its influencing factors. The results show that: (1) During the study period, Baishan City showed the characteristics that the production space first increased and then decreased, the ecological space decreased, and the living space continued to increase. Among them, the ecological space is the dominant space of Baishan City, covering an area of more than 80%. From the perspective of the transformation of PLES, from 2000 to 2020, Baishan City is mainly characterized by the transformation of ecological space into production space and living space. In the second type of space, forage ecological space, forestry ecological space and other ecological space have decreased, while other types of space have increased in varying degrees. (2) During the study period, the overall EEQI of Baishan City remained in good condition, and the ecological environment quality(EEQ) of the three periods were 0.6571, 0.6412 and 0.6562 respectively. The higher EEQI is distributed in Changbai County and Linjiang City, while the areas with lower EEQI are concentrated in the north-central part of Hunjiang City, the middle part of Jiangyuan District and the northwest of Fusong County. (3) According to the analysis of the influencing factors of EEQ, the influence of the factors of spatial differentiation of EEQI in Baishan City changed significantly from 2000 to 2020, and the average annual rainfall was the core factor affecting the spatial differentiation of EEQ in Baishan City, the second is the urbanization rate and the distance from the county government, and the interaction between the average annual rainfall and the distance from the county government has a strong influence on the spatial differentiation of EEQ in Baishan City. This study reveals the evolution of spatial types and EEQ of PLES in Baishan City, and provides a scientific reference for the effective management and utilization of land resources in Baishan City.
The correlation among occupational stress, coping style and depressive symptoms in 2,083 Chinese manufacturing workers
Authors: Li Xiaoyi , Chen Huiqing , Liao Xiqing , Huang Manqi , Liu Xiaoman , Guo Yao , Chen Jiabin , Li Shuang 
Published: May 2024

Abstract

Background
This study aims to investigate the correlation among occupational stress, coping style and depressive symptoms in manufacturing workers of China.
Methods
A total of 2,083 workers from two manufacturing enterprises in Beijing City and four manufacturing enterprises in Guangdong Province are selected as study subjects using judgment sampling method. The occupational stress, coping style, and depression symptoms are accessed using the Core Occupational Stress Measurement Scale, Trait Coping Style Questionnaire and Patient Health Questionnaire Depression Scale, and we analyze the correlation among occupational stress, coping style and depressive symptoms.
Results
A total of 2,311 questionnaires are distributed, and 2,083 valid questionnaires are collected, with a valid questionnaire recovery rate of 90.1%. The average scores of occupational stress, positive coping style, negative coping style and depressive symptoms among the study subjects are 45.2, 31.7, 23.7 and 6.3, respectively. The detection rates of occupational stress and depressive symptoms are 29.5% (615/2,083) and 15.7% (327/2,083). Depressive symptoms are positively correlated with occupational stress and negative coping style (both P < 0.001), and negatively correlated with positive coping style (P < 0.001). Occupational stress is positively correlated with negative coping style (P < 0.001) and negatively correlated with positive coping style (P < 0.001). The four dimensions of occupational stress explained 15.7% of variation in depressive symptoms (P < 0.001). The inclusion of the two dimensions of coping style on the above basis can explain 19.5% of the variation in depressive symptoms (P < 0.001). Meanwhile, the four dimensions of occupational stress has a statistically significant effect on depressive symptoms (P < 0.05).
Conclusions
Occupational stress can directly affect the occurrence of depressive symptoms in manufacturing workers of China. Coping style moderates the effect of occupational stress on depressive symptoms. Positive coping style can help alleviate the adverse effects of occupational stress and reduce the risk of depressive symptoms.
Clinical impact of pneumomediastinum in patients with myositis-associated interstitial lung disease
Authors: Jung Junghee , Kim Min Jee , Yoo Bin , Lee Chang-Keun , Kim Yong-Gil , Hong Seokchan , Ahn Soo Min , Kim Ho Cheol 
Published: May 2024

Abstract

Background: Idiopathic inflammatory myositis (IIM) frequently coexists with interstitial lung disease (ILD), significantly impacting morbidity and mortality. Spontaneous pneumomediastinum, a complication of myositis-associated ILD, remains understudied regarding its clinical implications.
Method: We retrospectively reviewed patients diagnosed with myositis-associated ILD at Asan Medical Center, Seoul, South Korea, from April 2012 to September 2023. Patients were categorized into two groups based on the presence or absence of spontaneous pneumomediastinum during the follow-up period.
Results: Among the 70 patients included in the study, the median age was 55.9 ± 12.2 years, with 62.9% being female. Pneumomediastinum developed in 12 (17.1%) patients. Clinical characteristics did not significantly differ between the pneumomediastinum and non-pneumomediastinum groups, except for the subtype of IIM. Notably, pneumomediastinum was observed in 11 (91.7%) patients with dermatomyositis and 1 (8.3%) with anti-synthetase syndrome (ASS), but none with polymyositis. Multivariate analysis revealed pneumomediastinum as a significant risk factor for mortality (hazard ratio: 2.829, 95% confidence interval: 1.100 – 7.270, p = 0.031) after adjusting for other variables. Patients with pneumomediastinum exhibited worse survival compared with patients without pneumomediastinum (median survival time: 77.7 ± 11.7 vs. 13.6 ± 3.7 months, p = 0.013).
Conclusion: Spontaneous pneumomediastinum is an independent risk factor for mortality in patients with myositis-associated ILD.
Virtual Reality for Assessing Emergency Medical Competencies in Junior Doctors – A Pilot Study
Authors: Keicher Franca , Backhaus Joy , König Sarah , Mühling Tobias 
Published: May 2024

Abstract

Background
The teaching and assessment of clinical-practical skills in medical education face challenges in adequately preparing students for professional practice, especially in handling emergency situations. This study aimed to evaluate the emergency medical competencies of junior doctors using Virtual Reality (VR)-based scenarios to determine their preparedness for real-world clinical situations.
Methods
Junior doctors with 0–6 months of professional experience participated in one of three VR-based emergency scenarios. These scenarios were designed to test competencies in emergency medical care. Performance was automatically assessed through a scenario-specific checklist, and participants also completed self-assessments and a clinical reasoning ability test using the Post-Encounter Form.
Results
Twenty-one junior doctors participated in the study. Results showed that while general stabilization tasks were performed well, there were notable deficiencies in disease-specific diagnostic and therapeutic actions. The average performance score was 65.6%, with no significant variance between different scenarios. Clinical reasoning ability was generally high (average 80.5%), indicating a robust ability to handle diagnostic decisions. Self-assessments did not correlate significantly with objective measures of competency, highlighting the subjective nature of self-evaluation.
Conclusion
VR-based simulations are effective for assessing emergency medical competencies in junior doctors, providing a detailed measure of their abilities across various emergency scenarios. The findings suggest that while participants are generally well-prepared for routine tasks, more focus is needed on complex case management. VR assessments could be an essential tool for evaluating and improving the readiness of new medical professionals for clinical practice.
Scedosporium boydii disseminated infection complicating severe SARS-CoV2 infection in an immunocompetent patient: a case report
Authors: Tenorio Adriana M Trejos , Roldán Daniel Montoya , Botero Alicia I Hidrón 
Published: May 2024

Abstract

Background:Disseminated disease by species in theScedosporiumgenus are rarein immunocompetent patients, and have not been reported in the context of severe SARS Cov-2 infection.Case presentation:A retired, 41-year-old police officer with a history of obesity and arterial hypertension presented to emergency department with acute respiratory hypoxemic failure due to severe SARS-Cov2 pneumonia. He used to practice home aquarium care, biking, river swimming, and fishing. He reported no recent travel to the sea, lakes, or caves. He required prolonged mechanical ventilation, and had several documented episodes of ventilator-associated pneumonia due toPseudomonas aeruginosaandKlebsiella pneumoniae,which later evolved to necrotizing pneumonia, multiple lung abscesses, bronchopleural fistula, empyema and subpleural abscess. Despite sedation withdrawal he remained unconscious; a brain MRI revealed multiple brain abscesses.Scedosporium boydiiwas isolated from both lung and brain abscess cultures. In addition to percutaneous drainage of lung abscesses, he was treated with combined therapy with voriconazole and liposomal amphotericin B, considering a possible synergic effect. Drainage of the multiple brain abscesses was not feasible; thus, radiological progression was documented, leading to the patient´s demise despite five weeks of treatment.Conclusion:Invasive fungal infections (IFIs) by molds are an emerging condition in patients with COVID-19. Cases of aspergillosis, candidiasis and mucormycosis were increasingly reported during the COVID-19 pandemic. This is the first report of a fatal disseminated infection due toScedosporium boydiipreceded by a severe SARS Cov-2 infection.
Cerebral tuberculoma in pregnant women: A systematic review and comprehensive analysis of literature
Authors: Vinueza Daniela , Rebellón-Sánchez David , Llanos Julio , Rosso Fernando 
Published: May 2024

Abstract

This systematic review and descriptive analysis examines the diagnostic and management complexities of cerebral tuberculomas in pregnant women, a condition that is infrequent and characterized by a wide spectrum of symptoms resembling those of other neurological diseases. We analyzed data from 26 cases across 16 countries between 1975 and 2024, highlighting the clinical manifestations, diagnostic strategies—including diverse interpretations of histopathological, imaging, and laboratory findings—and treatment options for tuberculomas during pregnancy. The absence of comprehensive guidelines for managing this condition underscores the urgent need for specialized knowledge and research in this area, aiming to improve outcomes for both pregnant women and their products of gestation.