bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRT letter: Contrast‐enhanced computed tomographic imaging of soft callus formation in fracture healing
Authors: Hayward Lauren Nicole Miller , Bakker Chantal Marie‐Jeanne DE , Lusic Hrvoje , Gerstenfeld Louis Charles , Grinstaff Mark W. , Morgan Elise Feng‐i 
Published: October 2011

AbstractFormation of a cartilaginous soft callus at the site of a bone fracture is a pivotal stage in the healing process. Noninvasive, or even nondestructive, imaging of soft callus formation can be an important tool in experimental and pre‐clinical studies of fracture repair. However, the low X‐ray attenuation of cartilage renders the soft callus nearly invisible in radiographs. This study utilized a recently developed, cationic, iodinated contrast agent in conjunction with micro‐computed tomography to identify cartilage in fracture calluses in the femora of C57BL/6J and C3H/HeJ mice. Fracture calluses were scanned before and after incubation in the contrast agent. The set of pre‐incubation images was registered against and then subtracted from the set of post‐incubation images, resulting in a three‐dimensional map of the locations of cartilage in the callus, as labeled by the contrast agent. This map was then compared to histology from a previous study. The results showed that the locations where the contrast agent collected in relatively high concentrations were similar to those of the cartilage. The contrast agent also identified a significant difference between the two strains of mice in the percentage of the callus occupied by cartilage, indicating that this method of contrast‐enhanced computed tomography may be an effective technique for nondestructive, early evaluation of fracture healing. Microsc. Res. Tech., 2012. © 2011 Wiley Periodicals, Inc.
MRT letter: Expression of ATP sensor protein in Caenorhabditis elegans
Authors: Kishikawa Jun‐Ichi , Fujikawa Makoto , Imamura Hiromi , Yasuda Kayo , Noji Hiroyuki , Ishii Naoaki , Mitani Shohei , Yokoyama Ken 
Published: October 2011

AbstractAdenosine 5′‐triphosphate (ATP) is the major energy currency and is involved in many biological processes. The ATP‐monitoring system for cells in animals can be helpful to study the relationship between energy metabolism and biological processes. The fluorescent ATP biosensor ATeam (ATP indicator based on Epsilon subunit for Analytical Measurements), which has been reported to monitor ATP levels in cultured cells on the basis of fluorescence resonance energy transfer (FRET), was introduced into nematodes by microinjection and UV‐irradiation method. To confirm whether ATeam functions as an ATP sensor in nematode cells, the authors measured FRET of ATeam in cells of transgenic nematode. The ATeam was expressed in target cells in nematode. In vulva cells, ATP levels in the cytosol were higher than those in mitochondria. ATeam also sensed ATP level change in cultured cells from the transgenic nematode. These experiments indicated that ATeam is available for detection of changes in ATP levels in nematode cells. Microsc. Res. Tech., 2012. © 2011 Wiley Periodicals, Inc.
Pocket card and dedicated feedback session to improve feedback to ward residents: A randomized trial
Authors: Peccoralo Lauren , Karani Reena , Coplit Lisa , Korenstein Deborah 
Published: October 2011

AbstractBACKGROUND:Residents are often dissatisfied with feedback received on the wards, and hospital attendings are often uncomfortable and unskilled at giving feedback.OBJECTIVE:Determine the impact of a pocket card and feedback session on Internal Medicine (IM) residents' perceptions of feedback and attendings' comfort giving feedback.DESIGN:Prospective randomized trial using chi‐square analysis.SETTING:Inpatient wards at 1 academic medical center.PARTICIPANTS:One hundred eleven IM residents and 36 attendings.INTERVENTION:We introduced a pocket feedback card, structured around the Accreditation Council for Graduate Medical Education competencies, and a feedback session to guide mid‐rotation feedback. Control group attendings received the usual reminder to provide feedback.MEASUREMENTS:Attendings' and residents' survey responses, after the inpatient month, assessing attitudes towards feedback and qualitative interviews with intervention attendings.RESULTS:Intervention residents were more likely than controls to report sufficient and useful feedback from attendings. They reported more feedback regarding skills needing improvement and how to improve their skills (51.3% vs 25.5%, P = 0.02), and felt their clinical (61.5% vs 27.8%, P = 0.001) and professionalism/communication (51.3% vs 29.1%, P = 0.03) skills improved based on this feedback. Intervention attendings, as compared to controls, agreed that residents improved their professionalism/communication skills (76.9% vs 31.1%, P = 0.02) based on feedback. Most intervention attendings found the card and session acceptable and would use both in the future.CONCLUSIONS:A pocket feedback card and dedicated feedback session improved the quantity and quality of feedback delivered to IM residents by their attendings on the inpatient wards. Journal of Hospital Medicine 2011;. © 2011 Society of Hospital Medicine
Inpatient staffing within pediatric residency programs: Work hour restrictions and the evolving role of the pediatric hospitalist
Authors: Oshimura Jennifer , Sperring Jeffrey , Bauer Benjamin D. , Rauch Daniel A. 
Published: October 2011

AbstractOBJECTIVE:In October 2010, the Accreditation Council for Graduate Medical Education (ACGME) mandated new standards that will further restrict resident work hours. There is growing concern surrounding the impact these restrictions will have on the staffing of inpatient services. The objective of this study was to survey the landscape of pediatric resident coverage of noncritical care inpatient teaching services prior to the implementation of these guidelines. In addition, we sought to explore how changes in work hour restrictions might affect the role of pediatric hospitalists in training programs.METHODS:In January 2010, an institutional review board (IRB)‐approved electronic survey was sent to 196 US residency training programs via the Association of Pediatric Program Directors (APPD) listserve.RESULTS:One hundred twenty responses were received representing 5201 pediatric residents. Of the programs that responded, 84% have hospitalists. At programs with hospitalists (n = 97), 24% have pediatric hospitalist attendings in‐house at night. Nearly a quarter of responding programs (22%) reported having no attending physicians in‐house at night. At the time of our survey, 31% of programs anticipated the addition of 24‐hour in‐house hospitalist coverage within the next 5 years. When the additional work hour restrictions are implemented, 70% of programs anticipated the need to add additional hospitalist coverage at night.CONCLUSIONS:Significant variation exists in how pediatric teaching services provide overnight coverage. While hospitalists are prevalent in pediatric training programs (84% overall, 67% day only), their role in direct patient care during the overnight hours has been limited thus far. New work hour restrictions will promote the need for more hospitalists. Journal of Hospital Medicine 2012;. © 2011 Society of Hospital Medicine.
Severe acute hypertension among inpatients admitted from the emergency department
Authors: Shorr Andrew F. , Zilberberg Marya D. , Sun Xiaowu , Johannes Richard S. , Gupta Vikas , Tabak Ying P. 
Published: October 2011

AbstractBACKGROUND:Hospitalists often treat patients with severe acute hypertension (AH) presenting to the hospital. Little is known about the epidemiology of this syndrome.OBJECTIVE:To examine the prevalence of severe AH in patients admitted through the emergency department (ED) and its associated outcomes.DESIGN:A cohort study using retrospectively collected vital signs and other clinical data.PATIENTS:A total of 1,290,804 adults admitted between 2005 and 2007.SETTING:One hundred fourteen acute‐care hospitals.MEASUREMENTS:Severe AH was defined as at least 1 systolic blood pressure (SBP) >180 mmHg. We used multivariable regression to estimate AH‐attributable in‐hospital mortality, need for mechanical ventilation (MV), and length of stay (LOS).RESULTS:Severe AH occurred in 178,131 (13.8%) patients. Disease categories with the highest prevalence were nervous (29.0%), circulatory (16.0%), endocrine (14.7%), and kidney/urinary (13.5%). The overall in‐hospital mortality was 3.6%. The relationship between severe AH strata and mortality was graded for nervous system diseases; mortality rates for each 10 mmHg increase in SBP from 180 to >220 mmHg were 6.5%, 8.1%, 9.9%, 12.0%, and 19.7%, respectively (P < 0.0001). The relationship between severe AH strata and need for MV was graded in the most pronounced way in respiratory and circulatory conditions (P < 0.0001). The relationship between severe AH strata and LOS was graded in most disease categories (P < 0.0001).CONCLUSIONS:Severe AH appears common and its prevalence varies by underlying clinical condition. Severe AH is associated with excess in‐hospital mortality for patients with nervous system diseases and, for most disease categories, prolongs hospitalization. Journal of Hospital Medicine 2011;. © 2011 Society of Hospital Medicine
Short‐term mortality among older persons hospitalized for pneumonia: Influence of baseline patient characteristics beyond severity of illness
Authors: Ding Yew Y. , Abisheganaden John , Chong Wai F. , Heng Bee H. , Lim T. K. 
Published: October 2011

AbstractBACKGROUND:Although severity of illness indices such as pneumonia severity index (PSI) are good predictors of short‐term mortality for community‐acquired pneumonia (CAP) and healthcare‐associated pneumonia (HCAP), other patient factors may have added prognostic value.OBJECTIVE:To identify patient factors beyond the PSI which explain 30‐day mortality among older persons hospitalized with CAP and HCAP.DESIGN:Retrospective cohort study.SETTING:Three acute care hospitals in Singapore in 2007.PATIENTS:Hospitalized adults aged 65 years or older who have primary International Classification of Diseases, 9th revision, Clinical Modification (ICD‐9‐CM) codes 480 to 486 with clinical and radiological features of pneumonia.INTERVENTIONS:None.MEASUREMENTS:Thirty‐day mortality, PSI class, demographic and clinical features, comorbid conditions, functional status, selected laboratory tests, and chest radiographic findings.RESULTS:Among 1607 patients included, 890 (55.4%) had CAP and 717 (44.6%) had HCAP. After adjustment for PSI class in logistic regression analyses, pre‐morbid ambulation impairment (odds ratio [OR] 2.61, 95% confidence interval [CI] 1.98 to 3.45), hospitalization in the prior 30 days (OR 1.93, 95% CI 1.38 to 2.71), and absence of cough and purulent sputum (OR 1.47, 95% CI 1.14 to 1.90) were all significantly associated with 30‐day mortality. These associations remained constant when CAP and HCAP were analyzed separately.CONCLUSIONS:Recent hospitalization, pre‐morbid ambulation impairment, and atypical presentation were independently associated with higher 30‐day mortality among older persons hospitalized for pneumonia, after adjusting for severity of illness. These factors could be considered in addition to PSI when performing risk stratification and adjustment in this setting. Journal of Hospital Medicine 2011;. © 2011 Society of Hospital Medicine.
Polydisulfide manganese(II) complexes as non‐gadolinium biodegradable macromolecular MRI contrast agents
Authors: Ye Zhen , Jeong Eun‐Kee , Wu Xueming , Tan Mingqian , Yin Shouyu , Lu Zheng‐Rong 
Published: October 2011

AbstractPurpose:To develop safe and effective manganese(II) ‐based biodegradable macromolecular MRI contrast agents.Materials and Methods:In this study, we synthesized and characterized two polydisulfide manganese(II) complexes, Mn‐DTPA cystamine copolymers and Mn‐EDTA cystamine copolymers, as new biodegradable macromolecular MRI contrast agents. The contrast enhancement of the two manganese‐based contrast agents were evaluated in mice bearing MDA‐MB‐231 human breast carcinoma xenografts, in comparison with MnCl2.Results:The T1 and T2 relaxivities were 4.74 and 10.38 mM−1s−1 per manganese at 3T for Mn‐DTPA cystamine copolymers (Mn = 30.50 kDa) and 6.41 and 9.72 mM−1s−1 for Mn‐EDTA cystamine copolymers (Mn = 61.80 kDa). Both polydisulfide Mn(II) complexes showed significant liver, myocardium and tumor enhancement.Conclusion:The manganese‐based polydisulfide contrast agents have a potential to be developed as alternative non‐gadolinium contrast agents for MR cancer and myocardium imaging. J. Magn. Reson. Imaging 2012;35:737‐744. © 2011 Wiley Periodicals, Inc.
Corticomedullary differentiation on T1‐Weighted MRI: Comparison between cirrhotic and noncirrhotic patients
Authors: Lee Karen S. , Muñoz Amelia , Báez Adán Bello , Ngo Long , Rofsky Neil M. , Pedrosa Ivan 
Published: October 2011

AbstractPurpose:To determine whether corticomedullary differentiation (CMD) is increased in patients with cirrhosis compared to controls on axial T1‐weighted magnetic resonance imaging (MRI).Materials and Methods:Sixty patients with cirrhosis and 60 age‐matched controls without renal disease underwent axial, T1‐weighted in‐phase gradient echo abdominal MRI. Each group of 60 was subdivided into three groups of 20 patients based on age: 18 to 45 years old; 45 to 65 years old; and greater than 65 years old. Signal intensity measurements of regions of interest obtained within the cortex and medulla of each kidney were recorded and the cortex‐to‐medulla contrast‐to‐noise ratio (CM‐CNR) was calculated. Each patient's estimated glomerular filtration rate (eGFR) was recorded.Results:Mean CM‐CNR for both kidneys in cirrhotic patients (19.1 ± 10.5) was significantly higher than in controls (12.4 ± 5.0) (P < 0.0001). No significant correlation was observed between CM‐CNR and eGFR levels for both cirrhotics and controls (P > 0.05). When stratified by age groups, no difference was observed in the mean CM‐CNR for both kidneys among these three subgroups for both cirrhotics and controls (P > 0.05).Conclusion:Cirrhotic patients with normal renal function have an increased CMD compared to age‐matched controls. J. Magn. Reson. Imaging 2012;35:644‐649. © 2011 Wiley Periodicals, Inc.
Simultaneous determination of tetrahydropalmatine and tetrahydroberberine in rat urine using dispersive liquid–liquid microextraction coupled with high‐performance liquid chromatography
Authors: Zhang Mingyong , Le Jian , Wen Jun , Chai Yifeng , Fan Guorong , Hong Zhanying 
Published: October 2011

AbstractDispersive liquid–liquid microextraction (DLLME) coupled with high‐performance liquid chromatography (HPLC)‐UV detection was applied in rat urine for the extraction and determination of tetrahydropalmatine (THP) and tetrahydroberberine (THB), both active components in Rhizoma corydalis. Various parameters affecting the extraction efficiency, such as the type and volume of extraction and dispersive solvent, pH, etc. were evaluated. Under the optimal conditions (extraction solvent: 37 μL of chloroform, dispersive solvent: 100 μL of methanol, alkaline with 100 μL of 1 mol/L NaOH, and without salt addition), the enrichment factors of THP and THB were more than 30. The extraction recoveries were 69.8–75.8% and 72.7–77.6% for THP and THB in rat urine, respectively. Both THP and THB showed good linearity in the range of 0.025–2.5 μg/mL, and the limit of quantification was 0.025 μg/mL (S/N=10, n=6). The intra‐day and inter‐day precision of THP and THB were <12.6%. The relative recoveries ranged from 95.5 to 107.4% and 96.8 to 100.9% for THP and THB in rat urine, respectively. The method has been successfully applied to rat urine samples. The results demonstrated that DLLME is a very simple, rapid and efficient method for the extraction and preconcentration of THP and THB from urine samples.
Toughening of PHBV/PBS and PHB/PBS Blends via In situ Compatibilization Using Dicumyl Peroxide as a Free‐Radical Grafting Initiator
Authors: Ma Piming , Hristova‐Bogaerds Denka G. , Lemstra Pieter Jan , Zhang Yong , Wang Shifeng 
Published: October 2011

AbstractPHB/PBS and PHBV/PBS blends are prepared via in situ compatibilization using DCP as a free‐radical grafting initiator. A considerable reduction in PBS particle size and a significant increase in the interfacial adhesion between the PHB(V) and PBS phases are observed after the compatibilization. The elongation at break of the PHBV/PBS blends was considerably increased. The local deformation mechanism indicates that matrix yielding together with dilatation, deformation, and fibrillation of the PBS particles are responsible for the improved tensile toughness of the compatibilized PHBV/PBS blends. The tensile strength, impact toughness, and elongation at break of injection‐molded PHB(homopolymer)/PBS blends are also increased after in situ compatibilization.magnified image
On the design of inscribed triangle non‐concentric circular fractal antenna
Authors: Kumar Raj , Sawant Kalias 
Published: October 2011

AbstractThis article presents the new ultra‐wideband fractal antenna with CPW‐fed.The fractal antenna has been fabricated on substrate εr = 4.3 mm and thickness h = 1.53 mm with 15‐mm radius. This antenna inscribed triangles in non‐concentric circles with varied radius offers the excellent bandwidth around 13.54 GHz (span from 1.335 to 14.88 GHz) corresponding to 167% impedance bandwidth at S11 < −10 dB. The first resonant frequency of fractal antenna shifted to 1.51 GHz by the application of fractal geometry in comparison to solid circular disc monopole first resonant frequency 2.215 GHz. This indicates the size reduction of the antenna. The experimental radiation patterns of the antenna are nearly omni directional. The proposed antenna is useful for mobile communication and UWB communication system. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2696–2699, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25555
A novel broadband patch antenna for universal UHF RFID tags
Authors: Huang Jun Zh. , Yang Peng H. , Chew Weng Cho , Ye Terry Tao 
Published: October 2011

AbstractA compact broadband patch antenna is proposed in this paper for global ultra‐high‐frequency (UHF) RF identification (RFID) applications. The antenna is composed of four synchronous shorted patches that resonate at four different frequencies, broadening its impedance bandwidth. A central loop is incorporated to feed the four patches simultaneously, which provides the required input reactance for matching to the chip as well. Since the current of neighboring patch is vertical to each other that they can radiate well without canceling each other, the gain is stable over the whole frequency band. Prototype is fabricated and tested, which shows that the impedance bandwidth can cover the whole UHF RFID band (840 MHz – 960 MHz), and the read range is over 3 meters when EIRP is set to 30 dBm at the reader. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2653–2657, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25560
Performance of double sideband modulated probe wave in BOTDA distributed fiber sensor
Authors: Cui Qingsong , Pamukcu Sibel , Lin Aoxiang , Xiao Wen , Toulouse Jean 
Published: October 2011

AbstractWe report on the performance of double sideband (DSB) modulated probe wave in Brillouin optical time domain analysis (BOTDA) distributed fiber sensor. Compared to single sideband (SSB) modulation, along the sensing fiber the pump depletion of DSB modulation is remarkably suppressed in time domain and also has a relatively narrower Brillouin gain spectrum in frequency domain. Both the theoretical simulation and the experimental results demonstrate that the DSB modulation provides potentially longer sensing distance and higher accuracy in measurement than the SSB modulation in the BOTDA distributed fiber sensor system. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2713–2717, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25566
CPW‐fed dielectric resonator antenna for ultra‐wideband applications
Authors: Weng Zi‐Bin , Wang Xiao‐Ming , Jiao Yong‐Chang , Zhang Fu‐Shun 
Published: October 2011

AbstractA new dielectric resonator antenna (DRA) is introduced for ultra‐wideband applications.In this structure, the DRA consists of three factors: a compact circular‐shaped dielectric resonator, a crescent patch, and a CPW feed ground. With the electromagnetic coupling between the feeding patch and the dielectric resonator, a broadband impedance bandwidth is achieved. Measured results demonstrate that the proposed DRA has a wide bandwidth from 1.6 to 15 GHz, and the measured return losses are less than −10 dB in this band. The experimental and numerical results are carried out showing a good agreement. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2709–2712, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25567
Design of a new compact dual‐mode multiband bandpass filter using multi‐armed ring‐open‐loop resonators without coupling gaps
Authors: Boutejdar Ahmed 
Published: October 2011

AbstractIn this article, we proposed at first step a new compact dual‐mode bandstop filter with broad stopband and low insertion loss in the passband using one ring resonator.Based of this microstrip ring resonator, a novel type of multibandpass filters is proposed. The idea of the proposed filters is to engineer the transmission band using multireject band resonators, which are implemented using multi‐armed open‐loop resonators that are directly coupled to the input/output ports. Each resonator pair of arms creates a reject band in the transmission response. By properly adjusting the multireject bands, appropriate multitransmission bands are created. The idea was verified by designing three different filters with multibandpass response. The designed and fabricated filters have compact size with good agreement between the measured and simulated responses. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2668–2672, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25576
Multibeam leaky‐wave antenna using slot and metasurface
Authors: Park Woo‐Young , Lim Sungjoon 
Published: October 2011

AbstractA novel multibeam leaky‐wave (LW) antenna is demonstrated in this letter.A beam passing through the defected ground structure is radiated at a fixed angle, while one passing through the D‐composite right/left‐handed metasurface moves from backward to forward including the broadside direction. The peculiar properties of both beams are described theoretically and experimentally according to the basic transmission line (TL) theory and Cherenkov radiation principles. By changing the frequency from 3.9 to 4.2 GHz, the angle of one beam changes from −7° to +10°, whereas that of the other is fixed at 55°. Therefore, the proposed multibeam LW antenna is suitable for detecting immovable and movable objects at the same time. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2759–2762, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25587
Impact of technology dispersion on slow‐wave high performance shielded CPW transmission lines characteristics
Authors: Franc A.‐L. , Kaddour D. , Issa H. , Pistono E. , Corrao N. , Fournier J.‐M. , Ferrari P. 
Published: October 2011

AbstractShielded coplanar waveguides are promising candidates for the development of high quality factor transmission lines in millimeter‐wave frequency bands. In this article, state‐of‐the‐art experimental results carried out on a CMOS 0.35 μm low‐cost technology are presented. This letter especially deals with the benchmark of slow‐wave transmission lines in focusing on the impact of technology dispersion on the measurement results. Eight dies have been measured, each from a different wafer, showing a robust design versus the technology. These results open new possibilities for the development of miniaturized low‐loss compact passive devices. © 2010 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52:2786–2789, 2010; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.25598