bluuebunny/crossref_metadata_2025_split huggingface dataset:
La psychanalyse, la réflexivité et l'enfant
Authors: Ody Michel 
Published: June 2012

Résumé À première vue, la notion de réflexivité, déjà utilisée dans de multiples champs de la connaissance, paraît superflue pour son utilisation en psychanalyse. Dans un second temps, sa confrontation avec les notions et concepts psychanalytiques montre en fait son utilité. L’auteur part d’une analogie discutée par lui il y a une quinzaine d’années à propos de la notion d’ insight , et en particulier chez l’enfant. Cette analogie vaut ici pour le trajet qu’elle opère à partir de celui processuel du devenir conscient freudien. La réflexivité, à son tour, élargit la question de l’ insight , de par sa connotation de retour, à celle du double retournement, dont les textes freudiens qui en traitent montrent que ce double retournement est le soubassement pulsionnel à la réflexivité, tant du côté des pulsions érotiques que des pulsions du moi. L’élargissement du travail analytique aux situations non névrotiques montre bien que les deux faces de la réflexivité, celle pulsionnelle érotique, celle avant tout narcissique pour sa face « miroir », sont impliquées. La reprise d’une analyse d’enfant tente d’illustrer ces propos.
Bion, la rêverie, la contenance et le rôle de la barrière de contact
Authors: Bronstein Catalina , Hacker Anne-Lise 
Published: June 2012

Résumé L’auteure explore la relation entre la capacité de penser et de réfléchir et les notions bioniennes de contenance maternelle et de lien K. La notion de contenance désigne la capacité de la mère de recevoir des identifications projectives de son petit enfant, de s’en servir comme communication et de les renvoyer sous une forme modifiée. Chez le petit enfant, cette fonction contribue au développement d’une barrière de contact, une structure perméable, mais qui sépare également le conscient et l’inconscient, permettant ainsi un passage sélectif d’éléments de l’un à l’autre. C’est sur ce fondement que s’établit une capacité de penser et de réfléchir. Les attaques contre le lien K peuvent amener à des états d’esprit – K (moins K), l’activité de penser sur le self et la curiosité à l’égard de celui-ci étant alors remplacées par des attaques contre l’activité de la pensée et l’évacuation d’éléments bêta. L’auteure suggère que cela peut également amener le patient à être bouleversé par des expériences sensorielles. Un exemple clinique illustre ces notions.
Germes de concepts psychanalytiques fondamentaux
Authors: Grubrich-Simitis Ilse , Lortholary Bernard 
Published: June 2012

Résumé Premier tome de l’édition intégrale des Brautbriefe , les lettres échangées entre Sigmund Freud et Martha Bernays pendant leurs fiançailles entre 1882 et 1886 ont été publiées l’an dernier dans l’édition originale allemande. Il s’agit de la correspondance de Freud la plus importante et la plus intime, dont seulement une petite sélection était jusqu’alors dans le domaine public. Ilse Grubrich-Simitis est coéditrice de ce document concernant la préhistoire de la psychanalyse, qui comprendra pour finir cinq volumes au total. Le XLVII e congrès de l’ api , qui s’est tenu à Mexico au début du mois d’août 2011, était consacré au thème : « Exploration des concepts fondamentaux : Sexualité, Rêves, Inconscient ». Dans la première partie de sa conférence d’ouverture, Ilse Grubrich-Simitis montre que ces premières lettres, y compris celles écrites par Martha, contiennent déjà les germes de concepts psychanalytiques fondamentaux ainsi que ceux de la méthode psychanalytique. Dans la seconde partie de sa conférence, deux portraits surgissent dans la lumière : Martha Bernays occupe le devant de la scène pour la première fois, tandis qu’apparaît une image fascinante, originale et complexe du jeune Freud.
The IL-2 Diphtheria Toxin Fusion Protein Denileukin Diftitox Modulates the Onset of Diabetes in Female Nonobese Diabetic Animals in a Time-Dependent Manner and Breaks Tolerance in Male Nonobese Diabetic Animals
Authors: Zinser Elisabeth , Rössner Susanne , Littmann Leonie , Pangratz Nadine , Schuler Gerold , Steinkasserer Alexander 
Published: June 2012

Abstract
Denileukin diftitox, also known as DAB389IL-2 or Ontak, is a fusion protein toxin consisting of the full-length sequence of the IL-2 protein and as toxophore the truncated diphtheria toxin. As a consequence, it delivers the toxic agent to CD25-bearing cells, whereby CD25 represents the high-affinity α-subunit of the IL-2 receptor. Initially it was developed for the treatment of patients with cutaneous T cell lymphoma. Meanwhile, denileukin diftitox is also used as an adjuvant in other tumor therapies and neoplastic disorders. In this study, to our knowledge we report for the first time that denileukin diftitox has also dramatic effects regarding the pathology of type 1 diabetes using the NOD mouse model. Repeated injections of denileukin diftitox into female NOD mice at 12 wk of age led to a clear acceleration of disease onset, whereas injection at 7 wk of age did not. Using male NOD mice, which are much less susceptible to diabetes, we demonstrate that the injection of denileukin diftitox leads to a dramatic development of type 1 diabetes within days after injection, thereby obviously breaking pre-existing tolerance mechanisms. This is accompanied by an increased IFN-γ production of autoreactive splenic cells and a decreased presence of regulatory CD4+CD25+Foxp3+ T cells. In contrast, transfer of CD4+CD25+Foxp3+ T cells could correct the defect after denileukin diftitox treatment. Furthermore, whereas IFN-γ production was increased in the pancreata of treated animals, insulin expression was strongly reduced. These finding should be considered when denileukin diftitox is used for the treatment of patients suffering from tumors and/or autoimmune disorders.
Redundant and Nonredundant Functions of ATM and H2AX in αβ T-Lineage Lymphocytes
Authors: Yin Bu , Lee Baeck-Seung , Yang-Iott Katherine S. , Sleckman Barry P. , Bassing Craig H. 
Published: June 2012

Abstract
The ataxia telangiectasia mutated (ATM) kinase and H2AX histone tumor suppressor proteins are each critical for maintenance of cellular genomic stability and suppression of lymphomas harboring clonal translocations. ATM is the predominant kinase that phosphorylates H2AX in chromatin around DNA double-strand breaks, including along lymphocyte Ag receptor loci cleaved during V(D)J recombination. However, combined germline inactivation of Atm and H2ax in mice causes early embryonic lethality associated with substantial cellular genomic instability, indicating that ATM and H2AX exhibit nonredundant functions in embryonic cells. To evaluate potential nonredundant roles of ATM and H2AX in somatic cells, we generated and analyzed Atm-deficient mice with conditional deletion of H2ax in αβ T-lineage lymphocytes. Combined Atm/H2ax inactivation starting in early-stage CD4–/CD8– thymocytes resulted in lower numbers of later-stage CD4+/CD8+ thymocytes, but led to no discernible V(D)J recombination defect in G1 phase cells beyond that observed in Atm-deficient cells. H2ax deletion in Atm-deficient thymocytes also did not affect the incidence or mortality of mice from thymic lymphomas with clonal chromosome 14 (TCRα/δ) translocations. Yet, in vitro-stimulated Atm/H2ax-deficient splenic αβ T cells exhibited a higher frequency of genomic instability, including radial chromosome translocations and TCRβ translocations, compared with cells lacking Atm or H2ax. Collectively, our data demonstrate that both redundant and nonredundant functions of ATM and H2AX are required for normal recombination of TCR loci, proliferative expansion of developing thymocytes, and maintenance of genomic stability in cycling αβ T-lineage cells.
Epigenetic Silencing of Cd8 Genes by ThPOK-Mediated Deacetylation during CD4 T Cell Differentiation
Authors: Rui Jinxiu , Liu Haifeng , Zhu Xiaoyan , Cui Yu , Liu Xiaolong 
Published: June 2012

Abstract
Intrathymic CD4/CD8 differentiation is a process that establishes the mutually exclusive expression profiles of the CD4 and CD8 T cell lineage. The RUNX3-mediated silencing of CD4 in CD8 lineage cells has been well documented; however, it is unclear how CD8 is silenced during CD4 lineage differentiation. In this study, we report that, by directly binding the CD8 locus, ThPOK works as a negative regulator that mediates the deacetylation of Cd8 genes and repositions the CD8 alleles close to heterochromatin during the development of the CD4 lineage. The ectopic expression of ThPOK resulted in increased recruitment of histone deacetylases at Cd8 loci; the enhanced deacetylation of Cd8 genes eventually led to impaired Cd8 transcription. In the absence of ThPOK, the enhanced acetylation and transcription of Cd8 genes were observed. The results of these studies showed that Cd8 loci are the direct targets of ThPOK, and, more importantly, they provide new insights into CD8 silencing during CD4 lineage commitment.
Furegrelate, a Thromboxane Synthase Inhibitor, Blunts the Development of Pulmonary Arterial Hypertension in Neonatal Piglets
Authors: Hirenallur‐S Dinesh K. , Detweiler Neil D. , Haworth Steven T. , Leming Jeaninne T. , Gordon John B. , Rusch Nancy J. 
Published: June 2012

The development of pulmonary arterial hypertension (PAH) in pediatric patients has been linked to the production of the arachidonic acid metabolite, thromboxane A2 (TxA2). The present study evaluated the therapeutic effect of furegrelate sodium, a thromboxane synthase inhibitor, on the development of PAH in a neonatal piglet model. Three‐day‐old piglets were exposed to 21 days of normoxia (N; 21% FIO2) or chronic hypoxia (CH; 10% FIO2). A third group of piglets received the oral TxA2 synthase inhibitor, furegrelate (3 mg/kg, 2 or 3 times daily) at the induction of CH. In vivo hemodynamics confirmed a 2.55‐fold increase of the pulmonary vascular resistance index (PVRI) in CH piglets (104±7 WU) compared to N piglets (40±2 WU). The CH piglets treated twice daily with furegrelate failed to show improved PVRI, but furegrelate three times daily lowered the elevated PVRI in CH piglets by 34% to 69±5 WU and ameliorated the development of right ventricular hypertrophy. Microfocal X‐ray computed tomography (CT) scanning was used to estimate the diameter‐independent distensibility term, α (% change in diameter per Torr). Pulmonary arterial distensibility in isolated lungs of CH piglets (α=1.0±0.1% per Torr) was lower than that of N piglets (α=1.5±0.1% per Torr) indicative of vascular remodeling. Arterial distensibility was partially restored in furegrelate‐treated CH piglets (α =1.2±0.1% per Torr) and microscopic evidence showing muscularization of small pulmonary arteries also was less prominent in these animals. Finally, isolated lungs of furegrelate‐treated piglets showed lower basal and vasodilator‐induced transpulmonary pressures compared to CH animals. These findings suggest that pharmacological inhibition of TxA2 synthase activity by furegrelate blunts the development of hypoxia‐induced PAH in an established neonatal piglet model primarily by preserving the structural integrity of the pulmonary vasculature.
Reactive Hyperplastic Lesions of the Gingiva: A Retrospective Study of 260 Cases
Authors: Ramu Sangeetha , Rodrigues Charlotte 
Published: June 2012

ABSTRACT

Objectives
The purpose of the study was to analyze the frequency and distribution of gingival lesions in MR Ambedkar Dental College, Bengaluru.

Materials and methods
The material included the biopsies of all localized reactive hyperplastic lesions (LRHL) of the gingiva stored in the department's database (1995-2011). The lesions were analyzed according to their location and the patient's age and gender. The findings were compared with other published studies on reactive lesions.

Results
A total of 260 reactive lesion biopsies were accessed. focal fibrous hyperplasia (FFH) was the most common (38.5%), followed by pyogenic granuloma (PG) (34.6%), peripheral ossifying fibroma (POF) (17.7%) and peripheral giant cell granuloma (PGCG) (9.2%). The mean age of the patients was 33 years, with a range varying from 9 to 80 years. The LRHL occurred more commonly in females except focal fibrous hyperplasia, which showed male predilection. PG and POF were more common in the maxilla and FFH as well as PGCG were more common in the mandible.

Conclusion
This study indicates some differences in age and gender distribution as well as in location between the different lesions. The results of this study differ from those of other studies and the data presented here can be used as a guide for further multicenter studies.

How to cite this article
Ramu S, Rodrigues C. Reactive Hyperplastic Lesions of the Gingiva: A Retrospective Study of 260 Cases. World J Dent 2012;3(2):126-130.
Effectiveness of Silorane-based Composite as a Repair Filling for Dimethacrylate- or Silorane-based Composite Restorations
Authors: Barcellos Daphne Câmara , Pucci Cesar Rogério , Torres Carlos Rocha Gomes , de Paiva Gonçalves Sergio Eduardo , Pleffken Patricia Rondon , Pagani Clovis 
Published: June 2012

ABSTRACT

Objective
This study aimed to evaluate the suitability of one specific silorane-based composite for the application as a repair material for different substrates.

Materials and methods
Truncated cones of composites fabricated and thermocycled for 6000 cycles to serve as a substrate were made of two commercially available dimethacrylate-based composites (DBC) (Filtek Supreme and Clearfil APX) and one silorane-based composite (SBC) (Filtek P90). The surface of the specimens was treated with air-abraded using Al2O3-particles of 50 µm size. A Teflon device was used to fabricate inverted truncated cones of repair composite over the surface-treated top of each original truncated cone. DBC and SBC were used as repair materials and bonded to the specimens using either a dimethacrylate-based (single bond 2) or a phosphate-methacrylate-based (adhesive belongs to the silorane) adhesives. The specimens were stored in distilled water at 37°C for 7 days and stressed to failure under tension. The data were analyzed with one-way ANOVA and Tukey tests at 5%.

Results
Bonding DBC as a repair material to a DBC substrate using the dimethacrylate-based adhesive produced the highest bond strength. Bonding DBC as repair material using the phosphate-methacrylate-based adhesive or SBC as repair material using the dimethacrylate-based adhesive produced lower bond strength, regardless the brand and of the chemical formulation of the aged substrate.

Conclusion
In order to obtain high bond strength, there is need to match adhesive and repair material, regardless the brand and of the chemical formulation of the substrate.

How to cite this article
Barcellos DC, Pleffken PR, Pucci CR, Pagani C, Gonçalves SEP, Torres CRG. Effectiveness of Silorane-based Composite as a Repair Filling for Dimethacrylate- or Silorane-based Composite Restorations. World J Dent 2012;3(2):161-65.
Bioactive Glass: A Material for the Future
Authors: Imran Zonera 
Published: June 2012

ABSTRACT
Bioactive glasses are novel dental materials that are different from conventional glasses and are used in dentistry. Bioactive glasses are composed of calcium and phosphate which are present in a proportion that is similar to the bone hydroxyapatite. These glasses bond to the tissue and are biocompatible. They have a wide range of medical and dental applications and are currently used as bone grafts, scaffolds and coating material for dental implants. This article reviews various properties of bioactive glasses and their applications and also reviews the changes that can be made in their composition according to a desired application.

How to cite this article
Farooq I, Imran Z, Farooq U, Leghari A, Ali H. Bioactive Glass: A Material for the Future. World J Dent 2012;3(2):199-201.
Management of Oral Pain
Authors: Pickett Frieda A 
Published: June 2012

ABSTRACT
Pain is the leading reason for individuals to seek dental care and understanding factors in pain response assists in pain management. Some dental services, including those involving tooth preparation, can result in postprocedure discomfort leading to a recommendation for analgesic therapy following treatment. Analgesia is defined as pain relief by inhibiting specific pain pathways and drugs to relieve pain are analgesics. Over the counter agents are efficacious agents for most dental pain with ibuprofen and acetaminophen commonly recommended. Considerations for analgesic recommendations, based on the medical history, scientific evidence of efficacy, and patient preferences are discussed.

How to cite this article
Pickett FA. Management of Oral Pain. World J Dent 2012;3(2):207-212.
Eating and Reading Hiromi Goto
Authors: Harris Lisa 
Published: June 2012

Hiromi Goto uses salted sour plums, cucumber and tonkatsu to expose the limits of reading and eating as ways of knowing gender and race. Ultimately, Goto argues, "difference exists, all cannot be understood." The narrator of Goto’s fictocriticism, Not Your Ethnic Body, describes herself through food to challenge how the female Japanese-Canadian body is consumed through writing. Yet she makes herself unpalatable to readers by prompting them to recoil and, thereby, to question their own reading practice.
Goto rarely provides secure ideological footing in her prose; although there is space to gender or racialize her characters, she never confirms the legitimacy of such assumptions. The narrator of The Kappa Child is ambiguously gendered, for example, and has an ambivalent relationship to cucumbers. The family meal in Chorus of Mushrooms interrupts food’s conciliatory role in multicultural exchange. Goto’s work demonstrates that culinary authenticity, when tied to a particular place or racial identity, is always socially constructed and subject to change.
Reading the Real: An Illustrated Tour of Montreal’s Marché Jean-Talon
Authors: Musgrave Sarah 
Published: June 2012

The slogan of Montreal's Marché Jean-Talon is "When country comes to town." An afternoon stroll through the city's largest public food market suggests that the word applies in both senses: country, as in the rural landscape, and country, as in the nations of the world. In surveying the cornucopia of place-based messages that greet potential shoppers, this paper positions the farmers’ market as a site for the consumption of authentic and authenticated foods, and thus a suitable microcosm for the exploration of larger issues related to consumer trends towards provenance purchasing, origin labelling, and the promotion of place as the primary marker of alimentary authenticity in the wider food marketplace.
De Versailles à Niamey. Le patrimoine constitutionnel canado-britannique du Québec et sa participation au sein de la Francophonie, 1968-1970
Authors: Meren* David 
Published: June 2012

Cet article analyse les événements entourant le débat sur la nature de la participation du Québec au sein de la Francophonie, de l’affaire Gabon (1968) jusqu’à la deuxième conférence de Niamey (1970), afin d’explorer les origines et les inspirations de l’activité internationale du Québec. Les récits antérieurs ont mis l’accent sur l’intérêt manifesté par les néonationalistes pour le développement de relations avec la France et la communauté internationale francophone et sur l’idée que le Québec devait se projeter sur la scène internationale afin de protéger ses juridictions constitutionnelles contre les empiétements fédéraux. Cet article soutient que toute analyse des circonstances entourant la participation du Québec à l’institutionnalisation de la Francophonie et des efforts qu’il déploie pour affirmer sa « capacité internationale » doit aussi tenir compte de l’évolution parallèle du Canada vers la souveraineté internationale d’une part, et du fait que les actions posées par le Québec s’inspirent en partie de son patrimoine constitutionnel canado-britannique d’autre part. Pour le Québec, l’appui de la France s’avère certes crucial pour l’obtention et le maintien d’une place à la table de la Francophonie. Pourtant, en accord avec les éléments pragmatiques et gradualistes de sa culture politique –un legs de son patrimoine britannique –, le Québec a dû, tout au long de ce processus, faire preuve de prudence dans ses relations avec la France, tant il est vrai que la compréhension qu’a Paris des réalités et des enjeux québécois demeurait imparfaite.
Mothers' negative focus during memory‐sharing conversations is linked to negative interpretation and memory biases in young children
Authors: Principe Gabrielle F. , Greenberg Daniel L. , Cibischino Amanda W. 
Published: June 2024

AbstractParent‐guided reminiscing helps children learn how to interpret and recollect personal experiences. These interpretive abilities are important because many experiences are ambiguous, and a tendency toward negative interpretation is associated with emotional disorders. Here, we explore whether naturally‐occurring variations in parent‐guided reminiscing are associated with children's interpretation and recall of novel ambiguous events. Mothers and their children (aged 5–6 years) reminisced about three shared negative events. Next, children were read several stories that described ambiguous social situations and were asked to invent endings that involved making an inference about motives of others in the stories. Later, children were asked questions to elicit story recall. Mothers who used more negative terms during reminiscing had children who were more likely to invent negative story endings and distort story recall negatively. Thus, mothers who frame memory‐sharing conversations with children negatively might put them at risk for developing negative interpretation and memory biases.
An Intelligent, Recyclable, Biomass Film for Adaptive Day‐Night and Year‐Round Energy Savings
Authors: Zeng Zhi‐Wei , Tang Bo , Zeng Fu‐Rong , Chen Hao , Chen Shi‐Qiang , Liu Bo‐Wen , Wang Yu‐Zhong , Zhao Hai‐Bo 
Published: June 2024

AbstractPassive radiative cooling is a zero‐energy technology vital for mitigating the energy crisis. However, achieving intelligent thermal management across varying weather conditions (day/night and summer/winter) while maintaining sustainability is a significant challenge. Here, a recyclable biomass film engineered for adaptive, year‐round energy conservation is introduced. This film utilizes porous acetyl cellulose (AC) as a cooling‐side matrix, enabling efficient radiative cooling during hot days (8.5 °C reduction) and minimizing overcooling on cold nights (only 2.5 °C reduction). This performance is facilitated by high solar reflectance (96.3%) and broad‐spectrum infrared emission (95.4%), optimizing atmospheric thermal regulation. The reverse side, coated with carbon black (CB), demonstrates superior solar heating (20.9 °C increase), allowing for effortless switching between cooling and heating by flipping the film. Further, the film employs a solvent‐responsive ethyl cellulose (EC) adhesion, ensuring durability, complete recycling, and reuse. With ultraviolet (UV) resistance, self‐cleaning, and durability, coupled with intelligent thermal management, this work provides new ideas for advanced radiative heat management materials, enabling adaptive control during both daytime/nighttime and summer/winter.