bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Implementation of the Madrasah Principal's Policies in Enhancing the Competence of Educators and Educational Staff of Islamic Junior High School (Perspective of the Independent Curriculum)
Authors: Dwiyono Yudo , Tannarong Yudhy 
Published: June 2024

This research aims to analyze the policies, implementation strategies, and influence of the policies of the Principal of the Islamic Middle School to improve the competence of educators and education staff based on the independent curriculum perspective. This research used a qualitative approach with a case study method. The informants in this research were the school principal, deputy principal for curriculum, educators/teachers, and education staff. The data was collected through in-depth interviews, observations, and documentary studies. The data analysis technique used the Miles and Huberman model with the following stages: (1) Data Collection, (2) Data Reduction, (3) Data Presentation, (4) Conclusion Drawing/Verification. Data validity used triangulation techniques, including source and technical triangulation. The results of the research show that: (1) the policies implemented by the principal of the Islamic Middle School, among others, recruitment of educators and educational staff is always adjusted to their qualifications or abilities, placement of educators and educational staff is based on competency, fostering active and communicative relationships with educators and educational staff, giving awards to educators and educational staff who excel; (2) the strategy of the principal of the Islamic Middle School includes: regular meetings, training, supervision, Subject Teacher Working Groups (MGMP), follow-up studies, and benchmarking; (3) The influence of the policy of the principal of the Islamic Middle School including increased accreditation, increased student achievement, and high public trust. The conclusion of this research is to implement the Islamic Middle School policy to improve the competence of educators and education personnel from the Independent Curriculum perspective.
LEXICAL DENSITY AND READABILITY IN STUDENTS’ THESIS INTRODUCTIONS
Authors: Siregar May Sarah , Hara Nina Tiya , Sinar Tengku Silvana 
Published: June 2024

This study investigates lexical density and readability in students’ undergraduate thesis introductions. Documentation technique is used to collect the data while qualitative content analysis was employed as the method to present the data. The data of this study were content words and sentences taken from the data sources of 20 undergraduate’s thesis introductions. The scores of lexical density and readability were obtained by using Flesch Reading Ease Tool online. The findings show that all introductions exhibit high lexical density, with scores ranging from 51,28% to 68,08%. Whilst, the readability scores range from 10.92 to 17.58, and they are all categorized as being very difficult writings. In summary, the findings demonstrate that all thesis introductions exhibit a high level of complexity in their writing. These introductions showcase the deliberate use of rich and precise content words. Consequently, they pose a significant challenge for comprehension due to their density.
Fanny Brawne and Criticism
Authors: Nersessian Anahid 
Published: June 2024

This paper considers the letters and the character of Frances ‘Fanny’ Brawne together as a model for criticism at the present time, as well as a meaningful indication of how criticism was practiced by laypeople in the Romantic period. Focusing on Keats’s great love affair rather than on Keats himself, or on Keats to the exclusion of his interlocuters, I describe the erotic conflict between Brawne and the poet as a form of agonistic engagement between writer and critic–the one tragic in impulse, the other more comic. Toward the end of the essay, I ask how conflict of this kind may be understood, in Stanley Cavell’s terms, not as the ugly underside of love but as one of its most significant expressions, a way of keeping up (in Cavell’s words) ‘the conversation love demands’. Throughout, the essay queries the relation between criticism and love, and how that relation might contest contemporary thinking around affect and pleasure.
RANCANG BANGUN SISTEM INFORMASI MONITORING BIMBINGAN TUGAS AKHIR BERBASIS WEB MENGGUNAKAN FRAMEWORK REACTJS
Authors: Setiawan La Ode Muhammad Ilham , Gunawan  , Tenriawaru Andi 
Published: June 2024

Proses bimbingan skripsi menjadi bagian penting dari proses pengerjaan tugas akhir yang dilakukan oleh mahasiswa. Bimbingan dilakukan dengan melibatkan dosen pembimbing dengan tujuan memberi tahu capaian yang telah dicapai dalam penulisan tugas akhir. Berdasarkan hasil observasi yang dilakukan, proses bimbingan tugas akhir yang ada di Program Studi Ilmu Komputer Universitas Halu Oleo masih dilaksanakan secara tatap muka sehingga sering terjadi komunikasi antara mahasiswa dan dosen pembimbing. Untuk mengefisienkan proses monitoring bimbingan tugas akhir mahasiswa Program Studi Ilmu Komputer. ReactJs merupakan library front-end yang dikembangkan oleh Meta. Keunggulan yang ditawarkan oleh reactJs diantaranya memberikan kecepatan, kemudahan dan skalabilitas yang luas. Tujuan dari penelitian ini adalah menghasilkan sebuah sistem informasi layanan monitoring bimbingan tugas akhir pada Program Studi Ilmu Komputer mengunakan framework ReactJS. Pemilihan reactJs dalam penelitian ini dikarenakan keunggulan serta kelebihan yang diberikannya. ReactJs dapat mengembangkan single page application dengan kecepatan, kemudahan serta skalabilitas yang luas. Karena kelebihan yang ditawarkan inilah framework reactJs mampu membantu mengembangkan sistem monitoring tugas akhir lebih efisien dan cepat. Berdasarkan hasil pengujian fungsional yang dilakukan menggunakan blackbox telah menunjukan hasil yang baik, begitu juga berdasarkan hasil pengujian menggunakan system usability scale yang dilakukan pada dosen dan mahasiswa telah menunjukan skor 87 dari 100 dengan kategori excellent serta skala A untuk pada pengujian SUS dosen serta skor 73 dari 100 dengan kategori Good serta grade scale yaitu B pada pengujian SUS mahasiswa. Dengan tingkat penerimaan untuk dosen dan mahasiswa berada pada skala accpetable atau dapat diterima.
Computer-aided design and implementation of efficient biosynthetic pathways to produce high added-value products derived from tyrosine in Escherichia coli
Authors: Ferreira Sofia , Balola Alexandra , Sveshnikova Anastasia , Hatzimanikatis Vassily , Vilaça Paulo , Maia Paulo , Carreira Rafael , Stoney Ruth , Carbonell Pablo , Souza Caio Silva , Correia João , Lousa Diana , Soares Cláudio M. , Rocha Isabel 
Published: June 2024

Developing efficient bioprocesses requires selecting the best biosynthetic pathways, which can be challenging and time-consuming due to the vast amount of data available in databases and literature. The extension of the shikimate pathway for the biosynthesis of commercially attractive molecules often involves promiscuous enzymes or lacks well-established routes. To address these challenges, we developed a computational workflow integrating enumeration/retrosynthesis algorithms, a toolbox for pathway analysis, enzyme selection tools, and a gene discovery pipeline, supported by manual curation and literature review. Our focus has been on implementing biosynthetic pathways for tyrosine-derived compounds, specifically L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine, with significant applications in health and nutrition. We selected one pathway to produce L-DOPA and two different pathways for dopamine–one already described in the literature and a novel pathway. Our goal was either to identify the most suitable gene candidates for expression in Escherichia coli for the known pathways or to discover innovative pathways. Although not all implemented pathways resulted in the accumulation of target compounds, in our shake-flask experiments we achieved a maximum L-DOPA titer of 0.71 g/L and dopamine titers of 0.29 and 0.21 g/L for known and novel pathways, respectively. In the case of L-DOPA, we utilized, for the first time, a mutant version of tyrosinase from Ralstonia solanacearum. Production of dopamine via the known biosynthesis route was accomplished by coupling the L-DOPA pathway with the expression of DOPA decarboxylase from Pseudomonas putida, resulting in a unique biosynthetic pathway never reported in literature before. In the context of the novel pathway, dopamine was produced using tyramine as the intermediate compound. To achieve this, tyrosine was initially converted into tyramine by expressing TDC from Levilactobacillus brevis, which, in turn, was converted into dopamine through the action of the enzyme encoded by ppoMP from Mucuna pruriens. This marks the first time that an alternative biosynthetic pathway for dopamine has been validated in microbes. These findings underscore the effectiveness of our computational workflow in facilitating pathway enumeration and selection, offering the potential to uncover novel biosynthetic routes, thus paving the way for other target compounds of biotechnological interest.
Clinical characteristics, viral dynamics, and antibody response of monkeypox virus infections among men with and without HIV infection in Guangzhou, China
Authors: Yang Huiqin , Xie Xiaoqing , Zeng Mou , Cao Yinghui , Fan Qinghong , Jiang Mengling , Lei Chunliang , Wang Jian , Li Feng , Tang Xiaoping , Yu Haisheng , Li Linghua 
Published: June 2024

BackgroundMonkeypox virus (MPXV) is spreading globally and nearly half of the infected people were human immunodeficiency virus (HIV) positive. Therefore, an in-depth understanding of the effects of HIV infection on the outcomes of MPXV infection is urgently needed. This study aimed to explore the clinical features, viral dynamics, and antibody response to MPXV infections in men who had sex with men (MSM) with and without HIV co-infection.Design or methodsMPXV-infected patients diagnosed by PCR were recruited in this study and were divided into MPXV and MPXV + HIV groups based on whether they were co-infected with HIV. Clinical data and samples were collected during of the hospital stay and follow up interviews. The symptoms and signs, laboratory examinations, viral shedding in various body fluids or swabs, antibody dynamics were tracked and compared between the two groups.ResultsA total of 41 MPXV patients were recruited through June 2023 to September 2023 in Guangzhou. The MPXV group and MPXV + HIV group comprised 20 and 21 MSM, respectively. Patients in the two groups exhibited similar clinical characteristics except for pruritus and eschar, both were significantly fewer in MPXV + HIV group than in MPXV only group. Among the 355 clinical samples collected, MPXV DNA was detected in 100% of scabs, 97.4% of skin swabs, and 92.3% of exudate swabs from lesions, while the positive rate was 87.5% from oropharyngeal swabs, 59% from saliva, 51.3% from anal swabs, 50% from feces, 30.6% from urine samples, 37.5% of semen, and 28.2% from sera. Dynamics analysis revealed that viral DNA was undetectable in most patients 20 days after symptom onset. IgM and IgG antibodies to MPXV were detected in all patients with 3–5 days earlier in the MPXV group than in the MPXV + HIV group.ConclusionThis cohort analysis based on a large outbreak among MSM in Guangzhou indicated no obvious differences in clinical symptoms, viral DNA data, but antibody responses were 3–5 days later in mpox patients with HIV infection.
Effects of high-intensity intermittent exercise on glucose and lipid metabolism in type 2 diabetes patients: a systematic review and meta-analysis
Authors: Feng Jingwen , Zhang Qiuhua , Chen Baoyi , Chen Jinping , Wang Wenjun , Hu Yuhang , Yu Jiabin , Huang Huiming 
Published: June 2024

ObjectiveTo evaluate the effects of high-intensity interval training (HIIT) on glycolipid metabolism among type 2 diabetes patients.MethodsHIIT is consistent with an exercise program (65%-90%VO2max or 75%-95% HRmax; exercise cycle≥2 weeks; frequency ≥ 2 times/week). A meta-analysis was conducted utilizing the random effects model to synthesize the data.ResultsA total of 22 RCT studies with 1034 diabetic patients were included. Compared to moderate-intensity aerobic exercise or conventional controls, HIIT yields noteworthy effects on FBG (MD: -0.55; 95% CI: -0.85- -0.25, Hedges’ g =0.98), 2h-PG (MD: -0.36; 95% CI: -0.57- -0.14, Hedges’ g =1.05), FINS (MD: -0.41; 95% CI: -0.79- -0.03, Hedges’ g =1.07), HbA1c (MD: -0.60; 95% CI: -0.84- -0.36, Hedges’ g =2.69), TC (MD: -0.58; 95% CI: -0.80- -0.36, Hedges’ g =2.36), TG (MD: -0.50; 95% CI: -0.86- -0.14, Hedges’ g =1.50), HDL (MD: 0.62; 95% CI: 0.29–0.95, Hedges’ g =1.19) and LDL (MD: -0.31; 95% CI: -0.56- -0.08, Hedges’ g =0.91), all of the above p&lt;0.01.ConclusionsHIIT has been shown to improve glucose and lipid metabolism in patients with type 2 diabetes, especially in HbA1c, TC, TG, and HDL. For patients between the ages of 40 and 60 with less than 5 years of disease, exercise programs of moderate to longer duration or moderate to high intensity will produce more favorable results.
Spatial-temporal changes of landscape ecological risk in the Liuchong river basin from the perspective of production-life-ecological space
Authors: Ren Jintong , Dong Yanqin , He Panxing , Lu Hanyu 
Published: June 2024

Promoting the construction of ecological civilization and sustainable development in karst mountainous areas by analyzing the spatial and temporal changes of landscape ecological risks is critical in karst mountainous watersheds. In this study, the land use transfer matrix, landscape ecological risk evaluation model, ecological contribution rate of land use change, and spatial autocorrelation analysis were combined to quantitatively analyze the land use and landscape ecological risk of a typical karst watershed, Liuchong River Basin, over the past 20 years. The results revealed that: 1) From 2000 to 2020, the functional classification of land use in the Liuchong River Basin was dominated by the woodland ecological space, and the most significant shifting characteristics were the increase in the area of watershed ecological space and industrial production space and the decrease in woodland ecological space, with shifts in the middle reaches of the Liuchong River being the most drastic; 2) Generally, the change of the regional landscape pattern was related to the transformation of the land use function type of “production-life-ecological space,” and the spatial aggregation of ecological risk level showed a gradual weakening trend. 3) The conversion of the watershed ecological space to the grassland ecological and agricultural production spaces, the conversion of urban living space to the agricultural production space, and the conversion of the rural living space to the agricultural production space were the dominant factors affecting ecological improvement, whereas the conversion of the woodland ecological space to the grassland ecological space, the woodland ecological space to the agricultural production space, and the grassland ecological space to the agricultural production space contributed to ecological degradation. The study findings can be used as a reference for the coordinated development of “production-life-ecological space” in karst watersheds and provide a scientific basis for ecological environmental protection and sustainable utilization.
Effects of flows on transparent exopolymer particles released from branching Acropora coral colonies
Authors: Wu Heng , Yamada Yosuke , Chuang Po-Shun , Ishikawa Kota , Mitarai Satoshi 
Published: June 2024

Transparent exopolymer particles (TEP), a major component of coral mucus, are responsible for particle aggregation. These particles contribute substantially to the carbon cycle in coral reefs, and serve as an energy source for bacteria and other microorganisms. Water flows and induced turbulent mixing control material exchange between the coral canopy and the surrounding water, which is critical for coral health. However, how these factors affect TEP release by coral colonies has yet to be evaluated. Using a recirculating flume, we assessed TEP release by branching Acropora coral colonies and associated bacterial growth in the water column under different unidirectional flows. Changes in TEP and bacterial concentrations after 24-h incubation were quantified for flow speeds of 0, 5, 10, and 30 cm/s. Particle image velocimetry (PIV) measurements provided an estimate of turbulent mixing efficiency above the coral canopy. TEP and bacterial concentrations in the water column increased after 24 h of incubation. The increase in TEP and bacterial concentrations were 6.2–9.3 times and 3.4–5.1 times higher in the absence of flows, respectively, than mean values under water flows. Although mixing efficiency increased linearly with mean flow speeds, TEP release and bacterial growth differed only marginally at flows ranging from 5–30 cm/s. Detailed flow measurements combined with evaluation of TEP release suggest that the complex geometry of corals facilitates efficient material exchange at a range of flow speeds, and highlight the importance of considering these factors when estimating coral reef biogeochemistry.
Serum parameters of inflammatory markers as prognostic biomarkers with maternal-neonatal outcome in patients with GDM
Authors: Xiu Xiaoyan , Lin Yingying , Chen Zhiwei , Lin Lin , Zu Yizheng , Yan Jianying 
Published: June 2024

ObjectiveGestational diabetes mellitus (GDM) is one of the most common complications of pregnancy, which is increasing annually. GDM can cause serious harm to both the mother and the offspring. However, the clinical indicators that predict pregnancy outcomes with GDM remain limited.MethodsThis study included 3,229 pregnancies. Inflammatory markers were defective in the mother’s peripheral blood. Also, the Chi-square test, logistic regression analyses and Spearman rank correlation coefficient were performed to evaluate inflammatory markers with pregnancy outcomes. The association between inflammatory markers and pregnancy outcomes was analyzed. The optimal cut-off values of inflammatory markers were calculated.ResultsFinally, 3,229 women were included. 1852 (57.36%) participants suffered good pregnancy outcomes. This study revealed that the maternal age, the baseline BMI (kg/m2), the times of parity, and the level of lymphocyte, SII and SIRI significantly increased in poor pregnancy outcomes groups. Additionally, inflammatory markers, such as white blood cells (WBC), neutrophils, monocytes, platelet counts, lymphocytes, systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were related to pregnancy outcomes. Furthermore, the results revealed that the SII level had the highest odd rates (OR) [OR = 6.957; 95% CI (5.715–8.468)], followed by SIRI level [OR = 2.948; 95% CI (2.382–3.649)], the WBC counts [OR = 1.930; 95% CI (0.901–2.960)], the lymphocyte counts [OR = 1.668; 95% CI (1.412–1.970)], and baseline BMI [OR = 1.050; 95% (1.021–1.080)].ConclusionThis study presented that the baseline SII and SIRI levels can be valuable biochemical markers to predict the pregnancy outcome with GDM with non-invasive procedures. They can help identify high-risk pregnant women with GDM early, provide a personalized intervention in time, and enhance perinatal surveillance.
Differential distribution of plasma apoA-I and apoB levels and clinical significance of apoB/apoA-I ratio in ischemic stroke subtypes
Authors: Van Tuyen Nguyen , Hoang Ngoc Nguyen , Quoc Hoan Phan , Thi Yen Nguyen , Hoan Nghiem Xuan , Cam Thach Nguyen 
Published: June 2024

Background and purposeIschemic stroke (IS) is classified into clinical subtypes and likely influenced by various lipid components. Nevertheless, the roles of apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), and apoB/apoA-I ratio in different IS subtypes remain underexplored. This study aimed to investigate the differential distribution of plasma apoA-I and apoB levels among IS subtypes and to evaluate the predictive value of the apoB/apoA-I ratio in assessing IS subtypes and disease severity.MethodsIn this study, 406 IS patients were categorized into three IS-subtypes based on clinical manifestations and imaging assessment, including intracranial atherosclerosis-related IS patients (ICAS, n = 193), extracranial atherosclerosis-related IS patients (ECAS, n = 111), and small artery occlusion-related IS patients (SAO, n = 102). Plasma apoA-I and apoB levels were measured upon hospital admission. Random forest (RF) models were performed to assess predictive values of these apolipoproteins apoB, apoA-I and their ratio in assessing IS subtype stratification and disease severity.ResultsSerum apoA-I levels were significantly lower in ICAS compared to ECAS and SAO patients (p &lt; 0.0001), while apoB levels were higher in ICAS patients (p &lt; 0.0001). The apoB/apoA-I ratio was significantly higher in ICAS compared to ECAS and SAO patients (p &lt; 0.0001). Correlation analyses found a significant correlation between the apoB/apoA-I ratio and conventional lipid components. Additionally, RF models and plots of variable importance and distribution of minimal depth revealed that the apoB/apoA-I ratio played the most influential predictor in predicting IS subtypes and stenosis severity.ConclusionOur study shows the differential distribution of apoA-I and apoB IS subtypes and reveals the significance of the apoB/apoA-I ratio in assessing IS subtypes and arterial stenosis severity. Further studies are warranted to validate these findings and enhance their clinical applicability.