bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term impact of digital media on brain development in children
Authors: Nivins Samson , Sauce Bruno , Liebherr Magnus , Judd Nicholas , Klingberg Torkel 
Published: June 2024

AbstractDigital media (DM) takes an increasingly large part of children’s time, yet the long-term effect on brain development remains unclear. We investigated how individual effects of DM use (i.e., using social media, playing video games, or watching television/videos) on the development of the cortex (i.e., global cortical surface area), striatum, and cerebellum in children over 4 years, accounting for both socioeconomic status and genetic predisposition. We used a prospective, multicentre, longitudinal cohort of children from the Adolescent Brain and Cognitive Development Study, aged 9.9 years when entering the study, and who were followed for 4 years. Annually, children reported their DM usage through the Youth Screen Time Survey and underwent brain magnetic resonance imaging scans every 2 years. Quadratic-mixed effect modelling was used to investigate the relationship between individual DM usage and brain development. We found that individual DM usage did not alter the development of cortex or striatum volumes. However, high social media usage was associated with a statistically significant change in the developmental trajectory of cerebellum volumes, and the accumulated effect of high-vs-low social media users on cerebellum volumes over 4 years was only β = − 0.03, which was considered insignificant. Nevertheless, the developmental trend for heavy social media users was accelerated at later time points. This calls for further studies and longer follow-ups on the impact of social media on brain development.
Breaking law of overburden rock and key mining technology for narrow coal pillar working face in isolated island
Authors: Feng Du , Zhenhua Li , Songtao Li , Xiaolei Li , Guodong Li , Xuan Fan , Hao Ren , Zhengzheng Cao 
Published: June 2024

AbstractWhen conducting retreat mining in segmented coal pillars, the dynamic evolution of stress and overlying strata structure is more complex than conventional working faces due to the influence of adjacent working faces. Understanding and mastering the dynamic evolution patterns of overlying strata structure after retreat mining in segmented coal pillar working faces is essential for guiding the safe recovery of coal pillar resources under similar conditions. Through statistical analysis of the types of residual coal and the mining techniques, the current research status of residual coal mining system in China has been summarized. Based on the safety recovery technology system for multi-type residual coal pillar resources at Zhaogu No.2 Mine, this paper focuses on narrow coal pillar working faces in sections with fully mined-out areas on both sides. By using research methods such as on-site measurement, theoretical analysis, numerical simulation, and engineering experiments, starting from the stress state analysis and evolution law of coal seam mining, the dynamic evolution law of the overlying rock structure of sectional coal pillars has been mastered. On this basis, a stress arch mechanical model of the mining area is constructed, and the working resistance of the support is calculated and determined, ensuring the safe recovery of the working face. The research results show that before the backfilling of the sectional coal pillar working face, the working face is affected by the overlapping mining of the goaf on both sides, presenting a “bimodal” stress distribution pattern, with a stress concentration coefficient between 1.78 and 3.2. After the extraction of segmented coal pillars, stress arches consisting of high-stress zones form along both the strike and dip of the working face. The structural support provided by stress arches undergoes a dynamic evolution process of “formation-development-elevation-stabilization” as the working face advances. Following the instability and rupture of the lower basic roof hinge structure, the stress-bearing structure shifts to the higher basic roof, continuing to provide support for the surrounding rock stress in the mining space of the working face. A stress arch mechanical model for the dip and strike of the mining area is constructed , and the shape characteristics of the overlying rock stress arch in the coal pillar working face is mastered. Based on the stress distribution law and stress arch evolution characteristics of the surrounding rock of the coal pillar working face, the maximum working resistance of the support in the working face is theoretically calculated to be 9153.48kN. Compared with the measured mine pressure data, the selected support effectively ensures the safety production of the working face.
Green extraction and application of yellow natural curcumin colorant from Curcuma aromatica rhizomes for silk dyeing
Authors: Habib Noman , Batool Fatima , Adeel Shahid , Naveed Muhammad , Ali Aamir , Mia Rony , Assiri Mohammed A. 
Published: June 2024

AbstractGreen products such as plant tints are becoming more and more well-known worldwide due to their superior biological and ayurvedic properties. In this work, colorant from Amba Haldi (Curcuma aromatica) was isolated using microwave (MW), and bio-mordants were added to produce colorfast shades. Response surface methodology was used to develop a central composite design (CCD), which maximizes coloring variables statistically. The findings from 32 series of experiments show that excellent color depth (K/S = 12.595) was established onto MW-treated silk fabric (RS = 4 min) by employing 65 mL of radiated aqueous extract (RE = 4 min) of 5 pH cutting-edge the existence of 1.5 g/100 mL used sodium chloride at 75 °C for 45 min. It was discovered that acacia (keekar) extract (1%), pomegranate extract (2%), and pistachio extract (1.5%) were present before coloring by the use of bio-mordants. On the other hand, upon dyeing, acacia extract (1.5%), pomegranate extract (1.5%), and pistachio extract (2%) have all shown extremely strong colorfast colors. Comparatively, before dyeing, salts of Al3+ (1.5%), Fe2+ (2%), and TA (1.5%) gave good results; after dyeing, salts of Al3+ (1%) and Fe2+ (1.5%) and TA (2%) gave good results. When applied to silk fabric, MW radiation has increased the production of dyes recovered from rhizomes. Additionally, the right amount of chemical and biological mordants have been added, resulting in color fastness ratings ranging from outstanding to good. Therefore, the natural color extracted from Amba Haldi can be a sustainable option for the dyeing of silk fabric in the textile dyeing and finishing industries.
Cu(II)-based complex loaded with drug paclitaxel hydrogels against thyroid cancer and optimizing novel derivatives
Authors: Wang Hui-Hui , Yin He-Liang , Yin Wei-Wei , Song Yong-Li , Chen Hong 
Published: June 2024

AbstractThis study introduces a novel approach for synthesizing a Cu(II)-based coordination polymer (CP), {[Cu(L)(4,4´-OBA)]·H2O}n (1), using a mixed ligand method. The CP was successfully prepared by reacting Cu(NO3)2·3H2O with the ligand 3,6-bis(benzimidazol-1-yl)pyridazine in the presence of 4,4´-H2OBA, demonstrating an innovative synthesis strategy. Furthermore, a novel hydrogel composed of hyaluronic acid (HA) and carboxymethyl chitosan (CMCS) with a porous structure was developed for drug delivery purposes. This hydrogel facilitates the encapsulation of CP1, and enables the loading of paclitaxel onto the composite to form HA/CMCS-CP1@paclitaxel. In vitro cell experiments demonstrated the promising modulation of thyroid cancer biomarker genes S100A6 and ARID1A by HA/CMCS-CP1@paclitaxel. Finally, reinforcement learning simulations were employed to optimize novel metal–organic frameworks, underscoring the innovative contributions of this study.
Unveiling genetic signatures associated with resilience to neonatal diarrhea in lambs through two GWAS approaches
Authors: Yaman Yalçın , Kişi Yiğit Emir , Şengül Serkan S. , Yıldırım Yasin , BAY Veysel 
Published: June 2024

AbstractNeonatal diarrhea presents a significant global challenge due to its multifactorial etiology, resulting in high morbidity and mortality rates, and substantial economic losses. While molecular-level studies on genetic resilience/susceptibility to neonatal diarrhea in farm animals are scarce, prior observations indicate promising research directions. Thus, the present study utilizes two genome-wide association approaches, pKWmEB and MLM, to explore potential links between genetic variations in innate immunity and neonatal diarrhea in Karacabey Merino lambs. Analyzing 707 lambs, including 180 cases and 527 controls, revealed an overall prevalence rate of 25.5%. The pKWmEB analysis identified 13 significant SNPs exceeding the threshold of ≥ LOD 3. Moreover, MLM detected one SNP (s61781.1) in the SLC22A8 gene (p-value, 1.85eE-7), which was co-detected by both methods. A McNemar’s test was conducted as the final assessment to identify whether there are any major effective markers among the detected SNPs. Results indicate that four markers—oar3_OAR1_122352257, OAR17_77709936.1, oar3_OAR18_17278638, and s61781.1—have a substantial impact on neonatal diarrhea prevalence (odds ratio: 2.03 to 3.10; statistical power: 0.88 to 0.99). Therefore, we propose the annotated genes harboring three of the associated markers, TIAM1, YDJC, and SLC22A8, as candidate major genes for selective breeding against neonatal diarrhea.
Heterogeneous seed-assisted FAPbI3 crystallization for efficient inverted perovskite solar cells
Authors: Yan Nan , Cao Yang , Dai Zhonghua , Jiang Long , Yang Yuanbo , Li Tiantian , Li Liwei , Liu Shengzhong (Frank) , Fang Zhimin , Feng Jiangshan 
Published: June 2024

A heterogeneous seed-assisted FAPbI3 crystallization facilitated by the 2,4-diaminopyrimidine (DAP) molecule, was employed to promotes the highly-crystalline α-FAPbI3 film, significant increasing the efficiency of inverted device to 25.29%.
Secondary cluster head based SEP in heterogeneous WSNs for IoT applications
Authors: Hossan Arif , Islam Jahidul 
Published: June 2024

AbstractA wireless sensor network (WSN) consists of specialized sensor nodes that perform sensing services for Internet of Things devices with limited battery power. As the replacement or recharging of batteries is not possible, energy consumption becomes the most important design issue in WSNs. The energy‐efficient routing protocol gets the most priority in such energy‐constrained networks. The utilization of clustering‐based routing protocols like stable election protocol (SEP) has gained much attention as the network's lifetime is significantly improved due to the clustering of sensor nodes. Moreover, the inclusion of a secondary CH (SCH) is beneficial when the member node with the most remaining energy performs data aggregation and reduces the energy burden of the CH. This article characterizes SEP and Prolong SEP (P‐SEP) protocols and then extends them by incorporating SCH, which ensures balanced energy consumption. The performance of the proposed Extended SEP and Extended P‐SEP protocols has been analysed regarding stability period, network lifetime, energy usage and throughput. The simulation results demonstrate that the proposed protocols outperform state‐of‐the‐art protocols like P‐SEP, Modified SEP (M‐SEP) and SEP. In particular, the stability period of Extended SEP and Extended P‐SEP has improved up to 42% and 89%, respectively, compared to M‐SEP.
A general matrix decomposition approach with application to stabilization of networked systems with stochastic sampling and two‐channel deception attacks
Authors: Li Yizhen , Hu Zhipei , Deng Feiqi , Su Yongkang , Li Guangjie 
Published: June 2024

AbstractThis study is concerned with the stabilization analysis and controller design for networked systems with stochastic sampling and two‐channel deception attacks. First, we give a general matrix decomposition approach which is applicable to scenarios where the system matrix contains complex‐value eigenvalues. Then, a discrete stochastic framework is established for a class of networked systems which considers the joint effects of sampling errors and two‐channel deception attacks. Utilizing the matrix decomposition approach introduced in this study, it becomes feasible to decouple the expectation operations for specific coupling matrices characterized by substantial nonlinearity and randomness. Based on this, a stabilization controller is constructed that ensures the exponential mean‐square stability of the resulting discrete stochastic system. Finally, three simulation examples are provided to validate the effectiveness of the proposed approach.
A high precision estimation algorithm for multi‐channel wide‐area surveillance ground moving target indication mode based on maximum likelihood method
Authors: Yan He , Xu Wenshuo , Liu Hui , Hao Jialin , Min Zhou , Zhu Daiyin 
Published: June 2024

AbstractA high precision estimation algorithm for ground moving targets in multi‐channel wide‐area surveillance ground moving target indication systems is proposed based on maximum likelihood method. The main concept of this novel algorithm is to estimate the azimuth angle of the detected targets using maximum likelihood method with the space steering vector formed by the estimated interferometric phase extracted from the mainlobe clutter region of the real data. Through this novel algorithm, the effect of channel errors among the multi‐channels can be well reduced. Simulation experiments demonstrate the effectiveness of the proposed algorithm.
iso-Guttiferone J and Structure Revision of Guttiferone J from Garcinia gummi-gutta: A Combined Experimental and Integrated QM/NMR Approach
Authors: Pandey Pankaj , Idrisi Mantasha , Ali Zulfiqar , Husain Islam , Neal William M. , Khan Shabana I. , Ferreira Daneel , Chittiboyina Amar G. , Khan Ikhlas A. 
Published: June 2024

AbstractMany polyprenylated acylphloroglucinols with fascinating chemical structures and intriguing biological activities have been identified as key to phytochemicals isolated from Garcinia, Hypericum, and related genera. In the present work, two chiral, tautomeric, highly-oxygenated polyprenylated acylphloroglucinols tethered with acyl and prenyl moieties on a bicyclo[3.3.1]nonanetrione core were isolated from the 95% ethanolic extract of Garcinia gummi-gutta fruit. The structures of both compounds were elucidated based on the NMR and MS data with ambiguity in the exact position of the enol and keto functions at C-1 and C-3 of the core structure. The structures of both polyprenylated acylphloroglucinols were established as a structurally revised guttiferone J and the new iso-guttiferone J with the aid of gauge-independent atomic orbital NMR calculations, CP3 probability analyses, specific rotation calculations, and electronic circular dichroism calculations in
combination with the experimental data. The structures of both compounds resemble hyperforin, a potent activator of the human pregnane X receptor. As expected, both compounds showed strong pregnane X receptor activation at 10 µM [7.1-fold (guttiferone J) and 5.0-fold (iso-guttiferone J)], explained by a molecular docking study, necessitating further in-depth investigation to substantiate the herb-drug interaction potential of G. gummi-gutta upon co-administration with pharmaceutical drugs.
Increased Glycolytic Activity Is Part of Impeded M1(LPS) Macrophage Polarization in the Presence of Urolithin A
Authors: Bahiraii Sheyda , Braunböck-Müller Barbara , Heiss Elke H. 
Published: June 2024

AbstractUrolithin A is a gut metabolite of ellagitannins and reported to confer health benefits, e.g., by increased clearance of damaged mitochondria by macroautophagy or curbed inflammation. One targeted cell type are macrophages, which are plastic and able to adopt pro- or anti-inflammatory polarization states, usually assigned as M1 and M2 macrophages, respectively. This flexibility is tightly coupled to characteristic shifts in metabolism, such as increased glycolysis in M1 macrophages, and protein expression upon appropriate stimulation. This study aimed at investigating whether the anti-inflammatory properties of urolithin A may be driven by metabolic alterations in cultivated murine M1(lipopolysaccharide) macrophages. Expression and extracellular flux analyses showed that urolithin A led to reduced il1β, il6, and nos2 expression and boosted glycolytic activity in M1(lipopolysaccharide) macrophages. The pro-glycolytic feature of urolithin A occurred
in order to causally contribute to its anti-inflammatory potential, based on experiments in cells with impeded glycolysis. Mdivi, an inhibitor of mitochondrial fission, blunted increased glycolytic activity and reduced M1 marker expression in M1(lipopolysaccharide/urolithin A), indicating that segregation of mitochondria was a prerequisite for both actions of urolithin A. Overall, we uncovered a so far unappreciated metabolic facet within the anti-inflammatory activity of urolithin A and call for caution about the simplified notion of increased aerobic glycolysis as an inevitably proinflammatory feature in macrophages upon exposure to natural products.
Spezielle medikamentöse und interventionelle Therapieverfahren der hypertrophen Kardiomyopathie
Authors: Seggewiß Hubert , Batzner Angelika 
Published: June 2024

ZusammenfassungDie hypertrophe Kardiomyopathie (HCM) ist die häufigste genetische kardiale Erkrankung mit einer Prävalenz von 0,2–0,6% und einer ausgeprägten pathologischen, pathophysiologischen und klinischen Varianz. Aufgrund der therapeutischen Möglichkeiten stehen die bei 70% der betroffenen Patient*innen vorhandene dynamische linksventrikuläre Obstruktion und die seit einigen Jahren in den Vordergrund getretene linksventrikuläre Hyperkontraktilität im Vordergrund des Interesses. Die symptomatische, nicht obstruktive HCM wird entsprechend den Therapieempfehlungen der Herzinsuffizienz behandelt. Therapie der ersten Wahl bei symptomatischer hypertropher obstruktiver Kardiomyopathie (HOCM) sind kardioselektive Betablocker und Verapamil als Nicht-Dihydropyridin-Kalziumantagonist. Selbstverständlich sollte aber zuvor der Einsatz gradientensteigender Medikamente vermieden werden. Bei Nichtansprechen ist aktuell der Septumreduktionstherapie mittels perkutaner Alkoholseptumablation oder in
Einzelfällen der chirurgischen Myektomie der Vorzug zu geben. Bei HOCM mit einer Ausflussbahnobstruktion ist die Behandlung mit Myosin-Inhibitoren zugelassen. Ob diese langfristig wegen zahlreicher offener Fragen (Wechselwirkungsspektrum, Risiko der Verschlechterung der systolischen linksventrikulären Funktion mit notwendigen Kontrolluntersuchungen, Kosten) eine flächendeckende Alternative darstellt, kann aktuell nicht beurteilt werden.
Endoscopic ultrasound- versus ERCP-guided primary drainage of inoperable malignant distal biliary obstruction: systematic review and meta-analysis of randomized controlled trials
Authors: Khoury Tawfik , Sbeit Wisam , Lisotti Andrea , Napoléon Bertrand , Fumex Fabien , Marasco Giovanni , Eusebi Leonardo H. , Fusaroli Pietro , Chan Shannon M. , Shahin Amir , Basheer Maamoun , Gincul Rodica , Leblanc Sarah , Teoh Anthony Y. B. , Jacques Jérémie 
Published: June 2024

Background We assessed efficacy and safety of endoscopic ultrasound-guided biliary drainage (EUS-BD) vs. endoscopic retrograde cholangiopancreatography (ERCP) as first-line intervention in malignant distal biliary obstruction (MDBO).
Methods PubMed/Medline, Embase, and Cochrane databases were searched until 01 /12 /2023 for randomized controlled trials of EUS-BD vs. ERCP for primary biliary drainage in patients with inoperable MDBO. The primary outcome was technical success. Secondary outcomes were clinical success, adverse events, mean procedure time, 1-year stent patency, and overall survival. Relative risk (RR) with 95 %CI were calculated using a random effects model.
Results Five studies (519 patients) were included. RR (95 %CI) for EUS-BD was 1.06 (0.96 to 1.17; P = 0.27) for pooled technical success and 1.02 (0.97 to 1.08; P = 0.45) for clinical success. 1-year stent patency was similar between the groups (RR 1.15, 0.94 to 1.42; P = 0.17), with lower reintervention with EUS-BD (RR 0.58, 0.37 to 0.9; P = 0.01). The RR was 0.85 (0.49 to 1.46; P = 0.55) for adverse events and 0.97 (0.10 to 0.17; P = 0.98) for severe adverse events. On subgroup analysis, EUS-guided placement of lumen-apposing metal stent (LAMS) outperformed ERCP in terms of technical success (RR 1.17, 1.01 to 1.35; P = 0.03). Procedure time was lower with EUS-BD (standardized mean difference –2.36 minutes [–2.68 to –2.05; P < 0.001]).
Conclusions EUS-BD showed a statistically significant lower reintervention rate than ERCP, but with similar technical success, stent patency, clinical success, and safety. Technical success of EUS-BD with LAMS was better than ERCP.
Sumatriptan for Postcraniotomy Headache after Minimally Invasive Craniotomy for Clipping of Aneurysms: A Prospective Randomized Controlled Trial
Authors: Venkatraghavan Lashmi , Shao Evan , Nijs Kristof , Dinsmore Michael , Chowdhury Tumul 
Published: June 2024

Abstract
Introduction Postcraniotomy headaches are often underestimated and undertreaded. This study aimed to identify if postoperative administration of sumatriptan after minimally invasive craniotomy for clipping an unruptured aneurysm could reduce postcraniotomy headache and improve the quality of postoperative recovery.
Settings and Design Tertiary care center, single-center randomized double-blind placebo-controlled trial.
Materials and Methods Patients who complained of postoperative headaches after minimally invasive craniotomy for clipping of unruptured aneurysms were randomized to receive subcutaneous sumatriptan (6 mg) or placebo. The primary outcome was the quality of recovery measured 24 hours after surgery. Secondary outcomes were total opioid use and headache score at 24 hours after surgery. Data were analyzed using a Student's t-test or the chi-square test.
Results Forty patients were randomized to receive sumatriptan (n = 19) or placebo (n = 21). Both groups had similar demographics, comorbidities, and anesthesia management. The Quality of Recovery 40 score was higher for patients receiving sumatriptan compared to placebo, however, not statistically significant (173 [156–196] vs. 148 [139–181], p = 0.055). Postoperative opioid use between sumatriptan and placebo was lower, but not significant (5.4 vs. 5.6 mg morphine equivalent, p = 0.71). The severity of headache was also not statistically different between the two groups (5 [4–5] vs. 4 [2–5], p = 0.155).
Conclusion In patients undergoing minimally invasive craniotomies for aneurysm clipping, sumatriptan given postoperatively has a nonsignificant trend for a higher quality of recovery. Similarly, there was a nonsignificant trend toward lower postcraniotomy headache scores and opioid scores for the patient given sumatriptan.