bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-alcoholic fatty liver disease in patients with atrial fibrillation: a report from a global federated health network
Authors: Bucci T , Baratta F , Pastori D , Pignatelli P , Violi F , Lip G Y H 
Published: May 2024

Abstract

Background
Few data are available on the clinical course of patients with Atrial Fibrillation (AF) and Nonalcoholic Fatty Liver Disease (NAFLD).

Purpose
To evaluate the 1-year risk of all-cause death, thromboembolic events, and bleeding in AF patients with NAFLD.

Methods
Retrospective cohort study within the global TriNetX platform. Patients with AF were categorized into two groups: i) AF with NAFLD and ii) AF without liver diseases. The primary outcomes were the 1-year risks of a composite outcome of i) all-cause death and thrombotic events (all-cause death, acute myocardial infarction, ischemic stroke, systemic arterial thromboembolism, deep vein thrombosis, and pulmonary embolism), and hemorrhagic outcome (intracranial hemorrhage and gastrointestinal bleeding). Secondary outcomes were each component of the composite primary outcomes. Cox regression analysis before and after propensity-score-matching (PSM) was used to estimate HR and 95% confidence interval (95%CI). Sensitivity analyses were done to investigate the risk associated with cirrhosis and type of oral anticoagulant.

Results
We identified 22,636 AF patients with NAFLD (69±12 years, 46.7% females) and 391,014 AF patients without NAFLD (72±12 years, 42.7% females). Before PSM, AF patients with NAFLD were younger, and with a higher prevalence of cardiovascular risk factors than those without liver disease. After PSM, no difference was found between the two groups, but NAFLD patients showed a higher 1-year risk of thrombotic (HR 1.54, 95%CI 1.47-1.61) and hemorrhagic (HR 1.56, 95%CI 1.42-1.72) composite outcomes (Figure 1). The higher risk in NAFLD was consistent also for all the secondary outcomes (Figure 1). On the sensitivity analyses (Figure 2), a progressively increased risk of thrombotic and hemorrhagic events was found in non-cirrhotic and cirrhotic patients compared to patients without liver diseases, whereas non-vitamin-k antagonist (NOAC) seems to be safer and more effective than warfarin.

Conclusion
In AF patients, NAFLD is associated with a higher 1-year risk of all-cause death, thrombotic and hemorrhagic events. Further studies are needed to establish the best clinical approach to manage NAFLD in AF patients.Figure 1Figure 2
Consistent accumulation of transposable elements in species of the Hawaiian Tetragnatha spiny-leg adaptive radiation across the archipelago chronosequence
Authors: Yang Heidi , Goubert Clément , Cotoras Darko D , Dimitrov Dimitar , Graham Natalie R , Cerca José , Gillespie Rosemary G 
Published: May 2024

Abstract
The ecological and phenotypic diversity observed in oceanic island radiations presents an evolutionary paradox: a high level of genetic variation is typically required for diversification, but species colonizing a new island commonly suffer from founder effects. This reduction in population size leads to lower genetic diversity, which ultimately results in a reduction in the efficiency of natural selection. What then is the source of genetic variation which acts as the raw material for ecological and phenotypic diversification in oceanic archipelagos? Transposable elements (TEs) are mobile genetic elements that have been linked to the generation of genetic diversity, and evidence suggests that TE activity and accumulation along the genome can result from reductions in population size. Here, we use the Hawaiian spiny-leg spider radiation (Tetragnatha) to test whether TE accumulation increases due to demographic processes associated with island colonization. We sequenced and quantified TEs in 23 individuals representing 16 species from the spiny-leg radiation and four individuals from its sister radiation, the Hawaiian web-building Tetragnatha. Our results show that founder effects resulting from colonization of new islands have not resulted in TE accumulation over evolutionary time. Specifically, we found no evidence for an increase in abundance of specific TE superfamilies, nor an accumulation of ‘young TEs’ in lineages which have recently colonized a new island or are present in islands with active volcanoes. We also found that the DNA/hAT transposon superfamily is by far the most abundant TE superfamily in the Tetragnatha radiation. This work shows that there is no clear trend of increasing TE abundance for the spiny-leg radiation across the archipelago chronosequence, and TE accumulation is not affected by population oscillations associated with island colonization events. Therefore, despite their known role in the generation of genetic diversity, TE activity does not appear to be the mechanism explaining the evolutionary paradox of insular diversification in the Tetragnatha spiny-leg radiation.
Evolutionary Rate Shifts in Coding and Regulatory Regions Underpin Repeated Adaptation to Sulfidic Streams in Poeciliid Fishes
Authors: De-Kayne Rishi , Perry Blair W , McGowan Kerry L , Landers Jake , Arias-Rodriguez Lenin , Greenway Ryan , Rodríguez Peña Carlos M , Tobler Michael , Kelley Joanna L 
Published: May 2024

Abstract
Adaptation to extreme environments often involves the evolution of dramatic physiological changes. To better understand how organisms evolve these complex phenotypic changes, the repeatability and predictability of evolution, and possible constraints on adapting to an extreme environment, it is important to understand how adaptive variation has evolved. Poeciliid fishes represent a particularly fruitful study system for investigations of adaptation to extreme environments due to their repeated colonization of toxic hydrogen sulfide–rich springs across multiple species within the clade. Previous investigations have highlighted changes in the physiology and gene expression in specific species that are thought to facilitate adaptation to hydrogen sulfide–rich springs. However, the presence of adaptive nucleotide variation in coding and regulatory regions and the degree to which convergent evolution has shaped the genomic regions underpinning sulfide tolerance across taxa are unknown. By sampling across seven independent lineages in which nonsulfidic lineages have colonized and adapted to sulfide springs, we reveal signatures of shared evolutionary rate shifts across the genome. We found evidence of genes, promoters, and putative enhancer regions associated with both increased and decreased convergent evolutionary rate shifts in hydrogen sulfide–adapted lineages. Our analysis highlights convergent evolutionary rate shifts in sulfidic lineages associated with the modulation of endogenous hydrogen sulfide production and hydrogen sulfide detoxification. We also found that regions with shifted evolutionary rates in sulfide spring fishes more often exhibited convergent shifts in either the coding region or the regulatory sequence of a given gene, rather than both.
Ancient Sheep Genomes Reveal Four Millennia of North European Short-Tailed Sheep in the Baltic Sea Region
Authors: Larsson Martin N A , Morell Miranda Pedro , Pan Li , Başak Vural Kıvılcım , Kaptan Damla , Rodrigues Soares André Elias , Kivikero Hanna , Kantanen Juha , Somel Mehmet , Özer Füsun , Johansson Anna M , Storå Jan , Günther Torsten 
Published: May 2024

Abstract
Sheep are among the earliest domesticated livestock species, with a wide variety of breeds present today. However, it remains unclear how far back this diversity goes, with formal documentation only dating back a few centuries. North European short-tailed (NEST) breeds are often assumed to be among the oldest domestic sheep populations, even thought to represent relicts of the earliest sheep expansions during the Neolithic period reaching Scandinavia &lt;6,000 years ago. This study sequenced the genomes (up to 11.6X) of five sheep remains from the Baltic islands of Gotland and Åland, dating from the Late Neolithic (∼4,100 cal BP) to historical times (∼1,600 CE). Our findings indicate that these ancient sheep largely possessed the genetic characteristics of modern NEST breeds, suggesting a substantial degree of long-term continuity of this sheep type in the Baltic Sea region. Despite the wide temporal spread, population genetic analyses show high levels of affinity between the ancient genomes and they also exhibit relatively high genetic diversity when compared to modern NEST breeds, implying a loss of diversity in most breeds during the last centuries associated with breed formation and recent bottlenecks. Our results shed light on the development of breeds in Northern Europe specifically as well as the development of genetic diversity in sheep breeds, and their expansion from the domestication center in general.
A CRISPR/Cas9-induced male-sterile line facilitating easy hybrid production in polyploid rapeseed (Brassica napus)
Authors: Tu Mengxin , Wang Ruisen , Guo Wenhui , Xu Shiqi , Zhu Yang , Dong Jie , Yao Xiangtan , Jiang Lixi 
Published: May 2024

Abstract
Rapeseed is a globally significant oilseed crop cultivated to meet the increasing demand for vegetable oil. In order to enhance yield and sustainability, breeders have adopted the development of rapeseed hybrids as a common strategy. However, current hybrid production systems in rapeseed have various limitations, necessitating the development of a simpler and more efficient approach. In this study, we propose a novel method involving the targeted disruption of Defective in Anther Dehiscence1 of Brassica napus (BnDAD1), an essential gene in the jasmonic acid biosynthesis pathway, using CRISPR/Cas9 technology, to create male-sterile lines. BnDAD1 was found to be dominantly expressed in the stamen of rapeseed flower buds. Disrupting BnDAD1 led to decreased levels of α-linolenic acid and jasmonate in the double mutants, resulting in defects in anther dehiscence and pollen maturation. By crossing the double mutant male-sterile lines with male-fertile lines, a two-line system was demonstrated, enabling the production of F1 seeds. The male-sterile trait of the bndad1 double mutant lines was maintainable by applying exogenous methyl jasmonate and subsequently self-pollinating the flowers. This breakthrough holds promising potential for harnessing heterosis in rapeseed and offers a simpler and more efficient method for producing hybrid seeds.
Functional data analysis-based yield modeling in year-round crop cultivation
Authors: Matsui Hidetoshi , Mochida Keiichi 
Published: May 2024

Abstract
Crop yield prediction is essential for effective agricultural management. We introduce a methodology for modeling the relationship between environmental parameters and crop yield in longitudinal crop cultivation, exemplified by strawberry and tomato production based on year-round cultivation. Employing functional data analysis (FDA), we developed a model to assess the impact of these factors on crop yield, particularly in the face of environmental fluctuation. Specifically, we demonstrated that a varying-coefficient functional regression model (VCFRM) is utilized to analyze time-series data, enabling to visualize seasonal shifts and the dynamic interplay between environmental conditions such as solar radiation and temperature and crop yield. The interpretability of our FDA-based model yields insights for optimizing growth parameters, thereby augmenting resource efficiency and sustainability. Our results demonstrate the feasibility of VCFRM-based yield modeling, offering strategies for stable, efficient crop production, pivotal in addressing the challenges of climate adaptability in plant factory-based horticulture.
Human papillomavirus vaccine coverage among immigrant adolescents in Alberta: a population-based cohort study
Authors: Du Crystal , Voaklander Don , Meherali Salima , Paudel Yuba Raj , MacDonald Shannon E 
Published: May 2024

Abstract

Background
Little is known about human papillomavirus (HPV) vaccination among immigrant children in Canada. We conducted a study in Alberta, Canada to assess HPV vaccine coverage among school-aged immigrant children compared with non-immigrant children.

Methods
This cohort study analysed population-based linked administrative health data to measure HPV vaccine coverage for 346 749 school-aged children, including 31 656 immigrants. Coverage was examined at 12 y of age from 2008 to 2018 for females, and from 2014 to 2018 for males and both sexes combined; vaccine series completion was considered receipt of three doses, with initiation (one or more dose) as a supplementary analysis. Multivariable logistic regression examined the association of vaccine coverage with migration status, adjusting for sociodemographic variables.

Results
Between 2014 and 2018, HPV vaccination coverage among immigrant children at age 12 y was significantly higher (52.58%) compared with non-immigrant children (47.41%). After controlling for place of residence, income quintile, biological sex and year, immigrant children had 1.10 greater odds (95% confidence interval 1.07 to 1.14) of receiving three doses of HPV vaccine compared with non-immigrant children. Immigrants from Asia and Africa had the highest coverage (60.25–68.78%), while immigrants from North America, Oceania and South America had the lowest coverage (39.97–48.36%).

Conclusions
It is encouraging that immigrant children had higher HPV vaccine coverage compared with non-immigrants. Among immigrants, routine immunization promotion strategies should be tailored based on the country of origin.
Lower Admission Prealbumin and Albumin Levels in Unhoused Burn Patients Is a Marker for Poorer Outcomes
Authors: Donohue Sean J , Baca Joseph , Speiser Noah , Pickering Trevor , Pham Christopher , Gillenwater Justin T , Yenikomshian Haig A 
Published: May 2024

Abstract
Unhoused (UH) individuals experience burn injuries at a higher rate than domiciled individuals, and have poorer outcomes following injuries. One such mechanism proposed for worsened outcomes is secondary to poor nutrition. Access to proper nutrition and food insecurity are major barriers. Malnutrition has been shown to decrease wound tensile strength, increase infection rates, and prolong healing. The purpose of this study was to understand if albumin and prealbumin could help determine outcomes in UH patients and identify at-risk patients earlier in their hospital course. A retrospective chart review was conducted of UH patients from 2015 through 2023 at a large urban safety net hospital. Data collected included admission laboratory values including albumin and prealbumin. Outcomes studied included length of stay (LOS), Intensive Care Unit (ICU) days, ventilator days, and mortality. Data analysis for the effect of albumin and prealbumin included a zero-truncated negative binomial model for LOS, a negative binomial hurdle model for ICU LOS and ventilator days, and logistic regression for mortality. Three hundred and eighty-five patients met inclusion criteria and of these, 366 had albumin and 361 had prealbumin information. Adjusting for age, gender, and total body surface area, the fewest days in the hospital and lowest odds of admission to the ICU occurred for those with admission albumin values of approximately 3.4-3.5 g/dL. Each unit (g/dL) decrease in albumin was associated with 3.19 times the odds of death (95% CI: 1.42, 7.69). Each unit (mg/dL) decrease in prealbumin was associated with 1.19 times the odds of death (95% CI: 1.06, 1.35). Decreased admission albumin and prealbumin levels are associated with worse burn outcomes in UH patients. These nutritional biomarkers may aid in determining which UH patients are suffering from food insecurity at injury onset. Obtaining these values on admission may help burn providers target nutritional goals in their most vulnerable patients.
Facilitating Culturally Competent Breast Imaging Care in South Asian Patients
Authors: Sharma Nidhi , Mehta Tejas S , Wahab Rifat A , Patel Miral M 
Published: May 2024

Abstract
South Asians are a rapidly growing subset of the Asian population in the United States. They comprise people from multiple countries with diverse beliefs, languages, and cultural identities and values. The incidence of breast cancer is rising in South Asian women in the United States, with earlier onset and predilection for HER2-enriched tumors. Despite the rising incidence of breast cancer, participation in screening remains lower than other populations. Health care inequities in South Asian women are multifactorial and may be due to traditional health beliefs and practices, language barriers, cultural differences, and lack of overall awareness. Developing a culturally sensitive environment in breast imaging clinic practice can lead to improved patient care and adherence. Given the scarcity of data specific to the South Asian population in United States, there is a need for health service researchers and practice leaders to obtain more high-quality data to understand the needs of South Asian patient populations.
Artificial neural network-based sequential approximate optimization of metal sheet architecture and forming process
Authors: Han Seong-Sik , Kim Heung-Kyu 
Published: May 2024

Abstract
This paper introduces a sequential approximate optimization method that combines the finite element method (FEM), dynamic differential evolution (DDE), and artificial neural network (ANN) surrogate models. The developed method is applied to address two optimization problems. The first involves metamaterial design optimization for metal sheet architecture with binary design variables. The second pertains to optimizing process parameters in multi-stage metal forming, where the discrete nature arises owing to changing tool geometries across stages. This process is highly non-linear, accumulating contact, geometric, and material non-linear effects discretely through forming stages. The efficacy of the proposed optimization method, utilizing ANN surrogate models, is compared with traditionally used polynomial response surface (PRS) surrogate models, primarily based on low-order polynomials. Efficient learning of ANN surrogate models is facilitated through the FEM and Python integration framework. Initial data for surrogate model training are collected via Latin hypercube sampling and FEM simulations. DDE is employed for sequential approximate optimization, optimizing ANN or PRS surrogate models to determine optimal design variables. PRS surrogate models encounter challenges in dealing with non-linear changes in sequential approximate optimization concerning discrete characteristics such as binary design variables and discrete non-linear behavior found in multi-stage metal forming processes. Owing to the discrete nature, PRS surrogate models require more data and iterations for optimal design variables. In contrast, ANN surrogate models adeptly predict non-linear behavior through the activation function’s characteristics. In the optimization problem of metal sheet architecture for design Target C, the ANN surrogate model required an average of 4.6 times fewer iterations to satisfy stopping criteria compared with the PRS surrogate model. Furthermore, in the optimization of multi-stage deep drawing processes, the ANN surrogate model required an average of 6.1 times fewer iterations to satisfy stopping criteria compared with the PRS surrogate model. As a result, the sequential global optimization method utilizing ANN surrogate models achieves optimal design variables with fewer iterations than PRS surrogate models. Further confirmation of the method’s efficiency is provided by comparing Pearson correlation coefficients and locus plots.
Capnodis tenebrionis (Coleoptera: Buprestidae), an important pest of stone fruits in the Mediterranean basin: current management strategies and prospects for integrated pest management
Authors: Nasouri Hussein 
Published: May 2024

Abstract
Capnodis tenebrionis (Linné) is a devastating pest of stone fruits (Prunus spp.) in the Mediterranean region. The endophytic root-boring larvae cause the main damage and can kill a large tree within 2 years. For several decades, with the absence of an effective biological control strategy, the management of this pest has mainly relied on the use of nonselective insecticides. These insecticides are applied either as a foliar spray targeting adults or as a soil treatment targeting neonate larvae. The search for alternative management options has increased since 2000 as a result of reduced efficacy of chemical control, decreased number of available insecticides, and the need for control measures suitable for organic stone fruit production. The main focus was on entomopathogenic nematodes and fungi. Several isolates/strains of these pathogens were found to be effective against larvae and adults of C. tenebrionis under laboratory and semi-field conditions. In this article, we review the current management options of C. tenebrionis, including chemical, biological, resilient rootstock, and cultural options. The prospects for developing an integrated management approach for this pest are also discussed.
Extracellular vesicles in cancer: golden goose or Trojan horse
Authors: Han Tao , Hao Qian , Chao Tengfei , Sun Qinggang , Chen Yitian , Gao Bo , Guan Liping , Ren Wenjie , Zhou Xiang 
Published: May 2024

Abstract
Intercellular communication can be mediated by direct cell-to-cell contact and indirect interactions through secretion of soluble chemokines, cytokines, and growth factors. Extracellular vesicles (EVs) have emerged as important mediators of cell-to-cell and cell-to-environment communications. EVs from tumor cells, immune cells, and stromal cells can remodel the tumor microenvironment and promote cancer cell survival, proliferation, metastasis, immune evasion, and therapeutic resistance. Most importantly, EVs as natural nanoparticles can be manipulated to serve as a potent delivery system for targeted cancer therapy. EVs can be engineered or modified to improve their ability to target tumors and deliver therapeutic substances, such as chemotherapeutic drugs, nucleic acids, and proteins, for the treatment of cancer. This review provides an overview of the biogenesis and recycling of EVs, discusses their roles in cancer development, and highlights their potential as a delivery system for targeted cancer therapy.
Telehealth Engaged Music for Pain Outcomes: A Music and Imagery Proof-of-concept Study with Veterans
Authors: Story Kristin M , Robb Sheri L , Bravata Dawn M , Damush Teresa M , Bair Matthew J 
Published: May 2024

Abstract
Music therapy interventions target biopsychosocial outcomes and are a non-pharmacological option for integrated pain management. To date, most music and pain studies have focused on acute pain, passive music experiences, and in-person delivery. The purpose of this study was to examine feasibility and acceptability and determine proof-of-concept for a newly developed telehealth music imagery (MI) intervention for Veterans with chronic pain. A single-group proof-of-concept pilot study was conducted with Veterans with chronic pain (n = 8). Feasibility was assessed through examination of recruitment, retention, and session/measure completion rates; acceptability through participant interviews; and whether the intervention resulted in clinically meaningful change scores (pre- to post-intervention) on measures of pain, anxiety, and depression at the individual level. For Veterans who passed eligibility screening, we had an enrollment rate of 89%, with good retention (75%). Overall, participating Veterans found the intervention acceptable, identified specific challenges with technology, and recommended an increased number of sessions. Preliminary outcome data for pain, anxiety, and depression were mixed, with some Veterans reporting clinically meaningful improvements and others reporting no change or worsening symptoms. Findings informed modifications to the telehealth MI intervention and the design of a larger pilot randomized controlled trial to assess feasibility and acceptability of the modified intervention in a larger population of Veterans with chronic pain using additional measures and a control condition.