bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic link between depression and musculoskeletal disorders: insights from Mendelian randomization analysis
Authors: Wang Yanpeng , Zhang Yinzhen , Zhao Changwei , Yang Hao , Ai Chenglong , Zhao Wenhai , Xu Ji 
Published: May 2024

BackgroundThe association between depression and musculoskeletal diseases has long been a subject of contentious debate. However, the causal relationship between the two remains uncertain. This study employs a two-sample Mendelian randomization (MR) analysis to investigate the causality between depression and six musculoskeletal diseases.MethodsIn this study, we performed MR analysis to systematically explore the causal relationship between depression and six musculoskeletal disorders. Single nucleotide polymorphisms (SNPs) that are linked to depression were employed as instrumental variables. To ensure robust and reliable conclusions, multiple analytical approaches were utilized, including inverse variance weighting(IVW), weighted median, and MR-Egger regression. Additionally, sensitivity analysis methods such as the MR-Egger intercept test, Cochran’s Q test, leave-one-out analysis, and funnel plot were employed.ResultsOur MR analysis revealed a significant association between depression and cervical spondylosis (depression: OR 1.003, 95% CI 1.002–1.005, P = 8.32E-05; major depressive disorder: OR 1.003, 95% CI 1.001–1.005, P = 0.0052). Furthermore, a strong correlation was noted between major depressive disorder (MDD) and knee osteoarthritis (KOA) (OR 1.299, 95% CI 1.154–1.463, P = 1.50E−5). Sensitivity analysis confirmed the robustness of these findings. Our independent validation study also corroborated these results.ConclusionThe MR analysis conducted in this study provides evidence supporting a genetic link between depression and cervical spondylosis, as well as KOA. Targeted interventions to manage depression in susceptible populations may contribute to lowering the risk of cervical spondylosis and KOA in these cohorts.
A tumor-like renal arteriovenous malformation on 18F-PSMA-1007 PET/CT: a case report
Authors: Feng Yaqi , Zhao Wenjiang , Feng Yawen , Dai Wenli 
Published: May 2024

BackgroundRenal arteriovenous malformations (rAVMs) are congenital abnormal pathways between renal arteries and veins that are rare in the general population. It is often misdiagnosed as malignant renal tumors with abundant blood supply, and the definitive diagnosis primarily relies on angiography. Multimodality imaging, including contrast-enhanced computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET)/CT plays an important role in the differential diagnosis of renal space-occupying lesions.Case presentationA 56-year-old man presented with abdominal distension, loss of appetite, and back pain without obvious cause 2 years ago, without nausea vomiting, or frequent urination. Gastroscopy and colonoscopy showed multiple polyps in the duodenum and colon. Abdomen contrast-enhanced CT revealed a mass of 1.6 × 1.4 cm in the left kidney, which was considered to be a malignant tumor. PET/CT was performed for further diagnosis; the 18F-fluorodesoxyglucose (18F-FDG) PET/CT scan showed mild uptake in the left renal mass, while no uptake of 18F- prostate-specific membrane antigen (PSMA) was observed. Following a multidisciplinary discussion, the possibility of renal AVMs was considered and subsequently confirmed by renal angiography as the diagnosis. Then, selective segmental renal artery embolization was performed for treatment.ConclusionRenal AVMs are extremely rare in clinical practice. Due to limited research on the application of 18F-FDG and 18F-PSMA PET/CT to renal AVMs, its role remains largely unexplored. With the increasing popularity of PET/CT imaging, comprehensive imaging of the disease has become indispensable. We report the first case of PSMA PET/CT imaging in renal AVMs, and when PSMA expression is absent in a renal mass, the possibility of renal AVMs should be considered.
Intimate partner violence perpetration among veterans: associations with neuropsychiatric symptoms and limbic microstructure
Authors: Rojczyk Philine , Heller Carina , Seitz-Holland Johanna , Kaufmann Elisabeth , Sydnor Valerie J. , Berger Luisa , Pankatz Lara , Rathi Yogesh , Bouix Sylvain , Pasternak Ofer , Salat David , Hinds Sidney R. , Esopenko Carrie , Fortier Catherine B. , Milberg William P. , Shenton Martha E. , Koerte Inga K. 
Published: May 2024

BackgroundIntimate partner violence (IPV) perpetration is highly prevalent among veterans. Suggested risk factors of IPV perpetration include combat exposure, post-traumatic stress disorder (PTSD), depression, alcohol use, and mild traumatic brain injury (mTBI). While the underlying brain pathophysiological characteristics associated with IPV perpetration remain largely unknown, previous studies have linked aggression and violence to alterations of the limbic system. Here, we investigate whether IPV perpetration is associated with limbic microstructural abnormalities in military veterans. Further, we test the effect of potential risk factors (i.e., PTSD, depression, substance use disorder, mTBI, and war zone-related stress) on the prevalence of IPV perpetration.MethodsStructural and diffusion-weighted magnetic resonance imaging (dMRI) data were acquired from 49 male veterans of the Iraq and Afghanistan wars (Operation Enduring Freedom/Operation Iraqi Freedom; OEF/OIF) of the Translational Research Center for TBI and Stress Disorders (TRACTS) study. IPV perpetration was assessed using the psychological aggression and physical assault sub-scales of the Revised Conflict Tactics Scales (CTS2). Odds ratios were calculated to assess the likelihood of IPV perpetration in veterans with either of the following diagnoses: PTSD, depression, substance use disorder, or mTBI. Fractional anisotropy tissue (FA) measures were calculated for limbic gray matter structures (amygdala-hippocampus complex, cingulate, parahippocampal gyrus, entorhinal cortex). Partial correlations were calculated between IPV perpetration, neuropsychiatric symptoms, and FA.ResultsVeterans with a diagnosis of PTSD, depression, substance use disorder, or mTBI had higher odds of perpetrating IPV. Greater war zone-related stress, and symptom severity of PTSD, depression, and mTBI were significantly associated with IPV perpetration. CTS2 (psychological aggression), a measure of IPV perpetration, was associated with higher FA in the right amygdala-hippocampus complex (r = 0.400, p = 0.005).ConclusionVeterans with psychiatric disorders and/or mTBI exhibit higher odds of engaging in IPV perpetration. Further, the more severe the symptoms of PTSD, depression, or TBI, and the greater the war zone-related stress, the greater the frequency of IPV perpetration. Moreover, we report a significant association between psychological aggression against an intimate partner and microstructural alterations in the right amygdala-hippocampus complex. These findings suggest the possibility of a structural brain correlate underlying IPV perpetration that requires further research.
The efficacy and safety of bilateral synchronous transcutaneous auricular vagus nerve stimulation for prolonged disorders of consciousness: a multicenter, double-blind, stratified, randomized controlled trial protocol
Authors: Wang Yan , Yang Li , Liu Wei , Zhou Qianhui , Huang Meiling , Zou Leyao , Feng Zhen , Bai Yang 
Published: May 2024

BackgroundTreatment of disorders of consciousness (DOC) poses a huge challenge for clinical medicine. Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation method, which shows potential in improving recovery of DOC. However, the evidence came from single-center, small-sample randomized controlled trial, which is insufficient to form a conclusion. Thereby, we propose a prospective, multicenter, double-blind, stratified, two-arm randomized controlled trial protocol to investigate the efficacy and safety of bilateral synchronous taVNS for treatment of DOC.MethodsWe aim to recruit 382 patients with prolonged DOC, and divide them into an active stimulation group and a sham stimulation group. The patients in the active stimulation group will receive bilateral synchronous taVNS with a 200 μs pulse width, 20 Hz frequency, and personal adjusted intensity. The sham stimulation group will wear the same stimulator but without current output. Both groups will receive treatment for 30 min per session, twice per day, 6 days per week lasting for 4 weeks. The clinical assessment including Coma Recovery Scale-Revised (CRS-R), Full Outline of Unresponsiveness (FOUR), Glasgow Coma Scale (GCS), and Extended Glasgow Outcome Scale (GOS-E) will be conducted to evaluate its efficacy. Heart rate variability (HRV), blood pressure, and adverse events will be recorded to evaluate its safety.DiscussionThese results will enable us to investigate the efficacy and safety of taVNS for DOC. This protocol will provide multicenter, large-sample, high-quality Class II evidence to support bilateral synchronous taVNS for DOC, and will advance the field of treatment options for DOC.Clinical trial registration:https://www.chictr.org.cn/showproj.html?proj=221851, ChiCTR2400081978.
Effects of different speed-accuracy instructions on perception in psychology experiments: evidence from event-related potential and oscillation
Authors: Li Haijian , Wang Xiaoshuang , Hamalainen Timo , Meng Zhaoli 
Published: May 2024

IntroductionIn cognitive behavioral experiments, we often asked participants to make judgments within a deadline. However, the most common instruction of “do the task quickly and accurately” does not highlight the importance of the balance between being fast and accurate.MethodsOur research aimed to explore how instructions about speed or accuracy affect perceptual process, focus on event-related potentials (ERPs) and event-related oscillations (EROs) of two brain responses for visual stimuli, known as P1 and N1. Additionally, we compared the conventional analysis approach with principal component analysis (PCA) based methods to analyze P1 and N1 ERP amplitude and ERO power.ResultsThe results showed that individuals instructed to respond quickly had lower P1 amplitude and alpha ERO than those who prioritized accuracy, using the PCA-based approach. However, these two groups had no differences between groups in the N1 theta band using both methods. The traditional time-frequency analysis method could not detect any ERP or ERO distinctions between groups due to limitations in detecting specific components in time or frequency domains. That means PCA is effective in separating these components.DiscussionOur findings indicate that the instructions given regarding speed and accuracy impact perceptual process of subjects during cognitive behavioral experiments. We suggest that future researchers should choose their instructions carefully, considering the purpose of study.
On the effects of 30.5 GHz sinusoidal wave exposure on glioblastoma organoids
Authors: Rampazzo Elena , Persano Luca , Karim Nissar , Hodgking George , Pinto Rosanna , Casciati Arianna , Tanori Mirella , Zambotti Alessandro , Bresolin Silvia , Cani Alice , Pannicelli Alessandro , Davies Ilan W. , Hancock Cristopher , Palego Cristiano , Viola Giampietro , Mancuso Mariateresa , Merla Caterina 
Published: May 2024

IntroductionGlioblastoma (grade IV) is the most aggressive primary brain tumor in adults, representing one of the biggest therapeutic challenges due to its highly aggressive nature. In this study, we investigated the impact of millimeter waves on tridimensional glioblastoma organoids derived directly from patient tumors. Our goal was to explore novel therapeutic possibilities in the fight against this challenging disease.MethodsThe exposure setup was meticulously developed in-house, and we employed a comprehensive dosimetry approach, combining numerical and experimental methods. Biological endpoints included a global transcriptional profiling analysis to highlight possible deregulated pathways, analysis of cell morphological changes, and cell phenotypic characterization which are all important players in the control of glioblastoma progression.Results and discussionOur results revealed a significant effect of continuous millimeter waves at 30.5 GHz on cell proliferation and apoptosis, although without affecting the differentiation status of glioblastoma cells composing the organoids. Excitingly, when applying a power level of 0.1 W (Root Mean Square), we discovered a remarkable (statistically significant) therapeutic effect when combined with the chemotherapeutic agent Temozolomide, leading to increased glioblastoma cell death. These findings present a promising interventional window for treating glioblastoma cells, harnessing the potential therapeutic benefits of 30.5 GHz CW exposure. Temperature increase during treatments was carefully monitored and simulated with a good agreement, demonstrating a negligible involvement of the temperature elevation for the observed effects. By exploring this innovative approach, we pave the way for improved future treatments of glioblastoma that has remained exceptionally challenging until now.
Genes associated with cellular senescence as diagnostic markers of major depressive disorder and their correlations with immune infiltration
Authors: Chen Juan , Xie Xin , Lin Min , Han Hong , Wang Tingting , Lei Qirong , He Rongfang 
Published: May 2024

BackgroundEmerging evidence links cellular senescence to the pathogenesis of major depressive disorder (MDD), a life-threatening and debilitating mental illness. However, the roles of cellular senescence-related genes in MDD are largely unknown and were investigated in this study using a comprehensive analysis.MethodsPeripheral blood microarray sequencing data were downloaded from Gene Expression Omnibus (GEO) database and retrieved cellular senescence-related genes from CellAge database. A weighted gene co-expression network analysis was used to screen MDD-associated genes. Protein-protein interactions (PPI) were predicted based on STRING data, and four topological algorithms were used to identify hub genes from the PPI network. Immune infiltration was evaluated using CIBERSORT, followed by a correlation analysis between hub genes and immune cells.ResultsA total of 84 cell senescence-related genes were differentially expressed in patients with MDD compared to healthy control participants. Among the 84 genes, 20 were identified to be associated with the MDD disease phenotype, and these genes were mainly involved in hormone-related signaling pathways (such as estrogen, steroid hormone, and corticosteroid) and immune and inflammatory pathways. Three genes, namely, JUN, CTSD, and CALR, which were downregulated in MDD, were identified as the hub genes. The expression of hub genes significantly moderate correlated with multiple immune cells, such as Tregs, NK cells, and CD4+ T cells, and the abundance of these immune cells markedly differed in MDD samples. Multiple microRNAs, transcription factors, and small-molecule drugs targeting hub genes were predicted to explore their molecular regulatory mechanisms and potential therapeutic value in MDD.ConclusionJUN, CTSD, and CALR were identified as potential diagnostic markers of MDD and may be involved in the immunoinflammatory mechanism of MDD.
Traduction technique et technicité de la traduction : organiser le dialogue entre monde professionnel et formations
Authors: Froeliger Nicolas 
Published: May 2024

Cet article aborde la question de l’adéquation entre les besoins du marché et les formations sous un angle essentiellement quantitatif, en rapprochant trois ensembles de données : un sondage effectué en 2022 par la Société française des traducteurs (SFT), renseignant essentiellement sur l’attitude des indépendants face à la technique et à la technicité de la traduction ; un deuxième conduit en 2021 sur les perceptions qu’ont de ces questions les traducteurs travaillant dans et pour des institutions (représentant le monde salarié) ; et un troisième réalisée auprès d’étudiants entrants et sortants au sein du réseau EMT (indicateur du travail accompli par les formations). Malgré des différences entre ces trois approches, il apparaît clairement que le dialogue existe, donne des résultats et doit être approfondi. Un des enseignements principaux de la confrontation de ces données est que l’on n’a pas encore tout à fait fini d’apprendre les arcanes de la
biotraduction lorsqu’on sort de formation, mais que celle-ci est souvent en avance sur le monde professionnel en ce qui concerne l’introduction des outils. Un autre est que la formation continue revêt une importance cruciale dans le secteur de la traduction et doit être approfondie.
Are Dividends and Share Buybacks Substitutes in a Tax-Free Environment? Evidence from the GCC
Authors: AlTaweel AbdulRahman M. , Alabdullah Yaqoub A. 
Published: May 2024

Purpose: We test whether dividends and share buybacks are substitutes in a tax-free environment. Firms in recent decades substituted buybacks for dividends due to the low tax rates on capital gains. Investors in the Gulf Cooperation Council (GCC) countries do not pay taxes on cash dividends, making the substitution between dividends and buybacks less relevant. Study design/ methodology/approach: We use an empirical approach using the Lintner (1956) model to estimate future dividend surprises, and subsequently run cross-sectional regressions using Fama-Macbeth (1973) to compare predicted dividend surprises with actual dividends paid and share repurchases.Sample and data: We collect data for firms headquartered in GCC countries from the World scope and DataStream databases, resulting in 8,729 firm-year observations spanning from 1993 to 2019.Results: We find that the dividend changes are positively related to share buyback yield. Firms that have positive (negative) dividend surprises are associated with more (less) repurchases activity. Our results suggest that dividends and repurchases are complements rather than substitutes in a tax-free environment. It supports the findings that taxes play an important consideration when firms decide their payout policy.Originality/value: This is the first paper that studies this substitution effect in payout policy in a tax-free environment.Research limitations/ implications: Limitations include lack of data prior to 2003 and other data availability limitations. Implications include how firms may decide their optimal payout policy and how repurchase regulations are set in the GCC.
JEL classification: G15, G35
GERAKAN LITERASI MASYARAKAT DI KECAMATAN SAPE KABUPATEN BIMA
Authors: Setiawan Agus , Tayeb Irfan , Waliyudin Waliyudin 
Published: May 2024

Gerakan literasi pengabdian masyarakat di pendidikan format menjadi ujung tombak dalam mengatasi literasi dasar masyarakat di desa, hal ini sebagai upaya mendorong maju perkembangan anak dalam mengatasi dampak perilaku negatif di tengah masyarakat. Lokus desa parangina salah satu desa di kecamatan sape yang literasi dasarnya tidak sedang baik-baik saja, maka untuk mengatasi permasalahan literasi ini perlu dilakukan dengan metode dengan tahapan sebagai berikut; 1). Melakukan koordinasi dengan masyarakat. 2). Ceramah menyampaikan materi literasi. 3). Melakukan pendampingan. Kegiatan gerakan literasi dapat memberikan manfaat wawasan kepada anak dan bagi orang tua. Temuan kegiatan pengabdian gemar literasi masyarakat adalah; 1). Mewujudkan pendidikan yang berkualitas sebab dalam proses pembelajarannya memberikan kesempatan kepada anak untuk bebas berkarya, berkreasi dan berimajinasi. 2). Kegiatan pembelajaran dengan menggunakan media berupa mewarnai memberikan motivasi kepada anak untuk memahami literasi (membaca dan menulis). 3). Adanya dukungan orang tuan dan masyarakat dalam kegiatan gemar literasi, hal ini diwujudkan dalam rekomendasi anak-anaknya untuk belajar di program literasi serta adanya dukungan tempat di masyarakat
Clinical and Laboratory Characteristics of COVID-19 Patients with Different Outcome, Treated with Convalescent Plasma
Authors: Дунаев И.А. , Потапнёв М.П. , Максимович А.В. , Гущина Л.М. , Карпенко Ф.Н. 
Published: May 2024

Проведен анализ клинических, функциональных и лабораторных показателей пациентов с COVID-19, получавших терапию плазмой иммунной анти-COVID-19 (CCP). Сравнение пациентов группы выздоровевших (n=84) и умерших (n=27) показало, что факторами риска смертельного исхода при проведении терапии являются: возраст более 65 лет, уровень потока кислорода через носовые канюли более 10 л/мин (p=0,00027), потребность в ИВЛ (p=0,02), повышенные уровни лейкоцитов и нейтрофилов периферической крови до трансфузии ССР (p=0,0055 и p=0,0063 соответственно), возрастание уровня нейтрофилов периферической крови (p=0,00027) и уровня СОЭ и С-реактивного белка после трансфузии ССР (p=0,0045 и p=0,0001 соответственно). Сделан вывод о различии прогностически значимых клинико-лабораторных показателей у пациентов, выздоровевших или впоследствии умерших, при применении терапии с использованием ССР.
The analysis of clinical, functional and laboratory parameters of patients with COVID-19 who received therapy with immune anti-COVID-19 plasma (CCP) was carried out. The comparison of groups the recovered (n=84) and deceased (n=27) patients showed that the risk factors for death were: age of patients over 65 years, the level of oxygen flow through nasal cannulas over 10 l/min (p=0.00027), need for mechanical ventilation (p=0.02), increased levels of leukocytes and neutrophils of peripheral blood before CCP transfusion (p=0.0055 and p=0.0063, respectively), increased levels of peripheral blood neutrophils (p=0.00027) and levels of ESR and C-reactive protein after CCP transfusion (p=0.0045 and p=0.0001, respectively). The conclusion was made for existence of discrepancy between prognostically significant clinical and laboratory parameters of patients with recovered or deceased outcome when used CCP in COVID-19 therapy.