bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triassic granitic magmatism in the Lancangjiang zone in southwestern China associated with Paleo-Tethys evolution and its control on tin mineralization
Authors: Zheng Mingjun , Sun Xiang , Santosh M. , Pei Tong , Xiao Ke , Si Xiaobo , Deng Jun 
Published: June 2024

Abstract
Tin deposits are predominantly associated with granitic rocks, yet the factors controlling tin enrichment in granites remain controversial. Here, we investigated the Daguanshan pluton within the central part of the Lincang batholith in the Lancangjiang zone, southwestern China, representing a northern extension of the Southeast Asian tin belt (spanning Thailand, Malaysia, and Indonesia) as part of the Paleo-Tethyan tectonic realm. The Daguanshan pluton, linked to the Hongmaoling tin deposit, is composed of variably evolved granite units, including hornblende-biotite granite, biotite granite, two-mica granite, and muscovite granite. Zircon U-Pb ages of the Daguanshan granite units range from 235.2 ± 0.7 Ma to 230.3 ± 1.2 Ma, consistent with the cassiterite U-Pb age of 238.2 ± 4.5 Ma for Hongmaoling mineralization. The four granite units have similar zircon εHf(t) values (−11.1 to −5.1) and bulk-rock εNd(t) values (−10.1 to −9.5) and show a magmatic fractionation trend. The less evolved hornblende-biotite granite and biotite granite, characterized as I-type granites, were probably derived from the remelting of early Paleozoic metamorphic igneous rocks in a postcollisional setting. Subsequently, the more evolved two-mica and muscovite granites emerged from these magmas, enriching tin contents from ~3.7 ppm to 25 ppm. Analysis of whole-rock Fe2O3/FeO ratios and zircon oxybarometry indicates that the oxygen fugacity of the less evolved granites was lower than the fayalite + magnetite + quartz (FMQ) buffer, and it decreased further with magma fractionation due to magnetite crystallization. Comparative assessments of the Daguanshan granites and the broader Lincang batholith, alongside Triassic tin granites in Southeast Asia, illuminate a cohesive tectonic origin linked to a collisional setting subsequent to the closure of the Paleo-Tethyan Ocean. These findings highlight the potential for significant tin mineralization within the highly evolved Triassic granites in the Lancangjiang zone.
Do various types of prelacteal feeding (PLF) have different associations with breastfeeding duration in Indonesia? A cross-sectional study using Indonesia Demographic and Health Survey datasets
Authors: Rahmartani Lhuri D , Quigley Maria A , Carson Claire 
Published: June 2024

IntroductionPrelacteal feeding (PLF) is anything other than breastmilk given to newborns in the first few days of birth and/or before breastfeeding is established. PLF comes in many forms and is known as a challenge to optimal breastfeeding. Interestingly, both breastfeeding and PLF are common in Indonesia. This study investigated the association between PLF (any PLF, formula, honey, water and other milk) and breastfeeding duration.MethodsThis study used Indonesia Demographic and Health Surveys data from 2002, 2007 and 2017. Sample sizes were 5558 (2007), 6268 (2007) and 6227 (2017) mothers whose last child was aged 0–23 months. We used Cox regression survival analysis to assess the association between PLF and breastfeeding duration, estimating hazard ratios (HR) for stopping earlier.ResultsOverall PLF was prevalent (59%, 67% and 45% in 2002, 2007 and 2017, respectively), with formula being the most common (38%, 50% and 25%). No association between any PLF and breastfeeding duration in 2002 (HR 0.90 (95% CI 0.70 to 1.16)), but in 2007 and 2017, mothers who gave any PLF were more likely to stop breastfeeding earlier than those who did not (HR 1.33 (95% CI 1.11 to 1.61) and 1.47 (95% CI 1.28 to 1.69), respectively), especially in the first 6 months (HR 2.13 (95% CI 1.55 to 2.92) and 2.07 (95% CI 1.74 to 2.47), respectively). This association was more consistent for milk-based PLF. For example, HR in 2017 was 2.13 (95% CI 1.78 to 2.53) for prelacteal formula and 1.73 (95% CI 1.39 to 2.15) for other milk. The associations were inconsistent for the other PLF types. Prelacteal water showed no association while prelacteal honey showed some association with a longer breastfeeding duration in 2002 and 2007.ConclusionThe impact of PLF on breastfeeding duration varied by type. While this study supports current recommendations to avoid PLF unless medically indicated, the potential consequences of different PLF types on breastfeeding outcomes should be clearly communicated to healthcare providers and mothers. Further research should explore the reasons for the high PLF prevalence in this setting.
Useful or not? The discussion of traditional Chinese medicine to treat COVID-19 on a Chinese social networking site
Authors: Wang Di , Lu Jiahui , Zhou Jiaming , Wong Vincent Kam Wai 
Published: June 2024

The use of traditional medicine is a global phenomenon, and the WHO advocated its appropriate integration into modern healthcare systems. However, there is a hot debate about the legitimacy of traditional medicine among the general public. Here, we investigated the debate in the Chinese digital context by analysing 1954 responses related to 100 questions about traditional Chinese medicine (TCM) treatment against COVID-19 on the Zhihu platform. Attitude function theory was applied to understand the reasons underlying public attitudes.Results showed that Zhihu users generally held a supportive attitude toward TCM. Their attitudes mainly came from their own experience and traditional media. The general users were more negative while medical professionals were more positive toward TCM. Ego defence (eg, derogating evidence sources) was used the most to support attitudes, followed by value expression (eg, believing in science). Supporters showed fewer expressions of faith (eg, the use of TCM is a kind of faith), politics (eg, supporting TCM is about politics) and science value (eg, TCM is a field of science), fewer ego defence, more patriotism and cultural confidence expressions (eg, TCM is a cultural pride) and more knowledge explanation (eg, TCM accelerates the metabolism of phlegm) than expected. Opposers showed fewer utilitarian and knowledge functions, fewer expressions of patriotism and more expressions of faith, politics and economics, but more ego defence functions than expected. Opposing posts were more likely to attract engagement than supporting and neutral posts. Posts that mentioned attitude functions generally attracted more engagement.Our findings indicate that TCM debate in modern China is not only relevant to medical science and health, but also rooted deeply in cultural ideology, politics and economics. The findings can provide global insights into the development of proactive policies and action plans that will help the integration of traditional medicine into modern healthcare systems.
Widening geographic range of Rift Valley fever disease clusters associated with climate change in East Africa
Authors: Situma Silvia , Nyakarahuka Luke , Omondi Evans , Mureithi Marianne , Mweu Marshal Mutinda , Muturi Matthew , Mwatondo Athman , Dawa Jeanette , Konongoi Limbaso , Khamadi Samoel , Clancey Erin , Lofgren Eric , Osoro Eric , Ngere Isaac , Breiman Robert F , Bakamutumaho Barnabas , Muruta Allan , Gachohi John , Oyola Samuel O , Njenga M Kariuki , Singh Deepti 
Published: June 2024

BackgroundRecent epidemiology of Rift Valley fever (RVF) disease in Africa suggests growing frequency and expanding geographic range of small disease clusters in regions that previously had not reported the disease. We investigated factors associated with the phenomenon by characterising recent RVF disease events in East Africa.MethodsData on 100 disease events (2008–2022) from Kenya, Uganda and Tanzania were obtained from public databases and institutions, and modelled against possible geoecological risk factors of occurrence including altitude, soil type, rainfall/precipitation, temperature, normalised difference vegetation index (NDVI), livestock production system, land-use change and long-term climatic variations. Decadal climatic variations between 1980 and 2022 were evaluated for association with the changing disease pattern.ResultsOf 100 events, 91% were small RVF clusters with a median of one human (IQR, 1–3) and three livestock cases (IQR, 2–7). These clusters exhibited minimal human mortality (IQR, 0–1), and occurred primarily in highlands (67%), with 35% reported in areas that had never reported RVF disease. Multivariate regression analysis of geoecological variables showed a positive correlation between occurrence and increasing temperature and rainfall. A 1°C increase in temperature and a 1-unit increase in NDVI, one months prior were associated with increased RVF incidence rate ratios of 1.20 (95% CI 1.1, 1.2) and 1.93 (95% CI 1.01, 3.71), respectively. Long-term climatic trends showed a significant decadal increase in annual mean temperature (0.12–0.3°C/decade, p<0.05), associated with decreasing rainfall in arid and semi-arid lowlands but increasing rainfall trends in highlands (p<0.05). These hotter and wetter highlands showed increasing frequency of RVF clusters, accounting for 76% and 43% in Uganda and Kenya, respectively.ConclusionThese findings demonstrate the changing epidemiology of RVF disease. The widening geographic range of disease is associated with climatic variations, with the likely impact of wider dispersal of virus to new areas of endemicity and future epidemics.
Understanding the extent of economic evidence usage for informing policy decisions in the context of India’s national health insurance scheme: Ayushman Bharat Pradhan Mantri Jan Aarogya Yojana (PM-JAY)
Authors: Sharma Deepshikha , Chauhan Akashdeep Singh , Guinness Lorna , Mehndiratta Abha , Dhiman Anamika , Singh Malkeet , Prinja Shankar 
Published: June 2024

IntroductionAyushman Bharat Pradhan Mantri Jan Aarogya Yojana (PM-JAY) is one of the world’s largest tax-funded insurance schemes. The present study was conducted to understand the decision-making process around the evolution (and revision) of health benefit packages (HBPs) and reimbursement rates within PM-JAY, with a specific focus on assessing the extent of use of economic evidence and role of various stakeholders in shaping these policy decisions.MethodsA mixed-methods study was adopted involving in-depth interviews with seven key stakeholders involved in HBP design and reimbursement rates decisions, and a survey of 80 government staff and other relevant stakeholders engaged in the implementation of PM-JAY. The data gathered were thematically analysed, and a coding framework was developed to explore specific themes. Additionally, publicly available documents were reviewed to ensure a comprehensive understanding of the decision-making processes.ResultsFindings reveal a progressive transition towards evidence-based practices for policy decisions within PM-JAY. The initial version of HBP relied heavily on key criteria like disease burden, utilisation rates, and out-of-pocket expenditures, along with clinical opinion in shaping decisions around the inclusion of services in the HBP and setting reimbursement rates. Revised HBPs were informed based on evidence from a national-level costing study and broader stakeholder consultations. The use of health economic evidence increased with each additional revision with consideration of health technology assessment (HTA) evidence for some packages and reimbursement rates based on empirical cost evidence in the most recent update. The establishment of the Health Financing and Technology Assessment unit further signifies the use of evidence-based policymaking within PM-JAY. However, challenges persist, notably with regard to staff capacity and understanding of HTA principles, necessitating ongoing education and training initiatives.ConclusionWhile substantial progress has been made in transitioning towards evidence-based practices within PM-JAY, sustained efforts and political commitment are required for the ongoing systematisation of processes.
Study of self-bound compact stars in $$f(\mathscr {T})$$ gravity and observational constraints on the model parameters
Authors: Maurya S. K. , Chaudhary Himanshu , Ditta Allah , Mustafa G. , Ray Saibal 
Published: June 2024

AbstractThe present study is based on $$f(\mathscr {T})$$

f
(
T
)

gravity, where we impose possible observational constraints on the model parameters to obtain physically plausible features of compact stars, specifically neutron stars. To do so, as a first step, we consider the field equations in the $$f(\mathscr {T})$$

f
(
T
)

gravity framework. We then solve the field equations to generate a set of new exact solutions in $$f(\mathscr {T})$$

f
(
T
)

gravity where model parameters are found by using boundary conditions. A few tests are performed to asses the stability of the model and compare the obtained results with observations of compact stars, in particular with the compact binary merger event GW190814. We observe the maximum mass of the star beyond the $$3M_{\odot }$$

3

M
⊙

when the surface density is of the order $$10^{14}$$

10
14

gm/cm$$^3$$

3

for the higher torsion parameter, which implies that an anisotropic solution in teleparallel gravity is more suitable for modeling of massive compact objects in lower $$mass-gap$$

m
a
s
s
-
g
a
p

, and thus the model presented herein provides a satisfactory physical scenario with respect to the observational signature.
Euler–Heisenberg black hole surrounded by perfect fluid dark matter
Authors: Ma Shi-Jie , Wang Rui-Bo , Deng Jian-Bo , Hu Xian-Ru 
Published: June 2024

AbstractA generation method of new metric in the case of static spherically symmetric space-time is derived. Using this approach, we construct a metric which describes Euler–Heisenberg black hole surrounded by perfect fluid dark matter and investigate its optical and thermodynamic properties. We found that radius of shadow will increase with the increase of dark matter effect, and more strong dark matter will diminish the light intensity of accretion disk generally. Moreover, in thermodynamics, when quantum electrodynamic parameter is positive, there will be a critical value of dark matter parameter, which determine the number of black hole’s critical points.
SMEFT chromomagnetic dipole operator contributions to $$t{{\bar{t}}}$$ production at approximate NNLO in QCD
Authors: Kidonakis Nikolaos , Tonero Alberto 
Published: June 2024

AbstractWe study higher-order QCD corrections for the production of a top–antitop quark pair ($$t{{\bar{t}}}$$

t

t

¯

production) at the Large Hadron Collider in the Standard Model Effective Field Theory. We consider effects of new physics parametrized by the top-quark chromomagnetic dipole operator. We calculate new physics contributions to the total cross section at approximate NNLO, with second-order soft-gluon corrections added to the complete NLO result, including uncertainties from scale dependence and from parton distributions. We also calculate new physics contributions at approximate NNLO for differential distributions in top-quark transverse momentum.
Influence of quantum correction on the Schwarzschild black hole polarized image
Authors: Guo Sen , Huang Yu-Xiang , Liu Kuan , Liang En-Wei , Lin Kai 
Published: June 2024

AbstractUsing a model of an accretion disk around a Schwarzschild black hole, the analytic estimates for image polarization were derived by Narayan et al. (Astrophys J 102:912, 2021). Recently, the EHT team also obtained polarization images of the Sgr A$$^{*}$$

∗

and measured both linear and circular polarization (Astrophys J Lett 964:L25, 2024). We find that quantum correction effects can also influence polarization information. Considering the quantum corrected Schwarzschild black hole (Kazakov–Solodukhin black hole), we derive the polarization intensity of the target black hole and investigate polarization images under different parameters. It is found that a larger quantum deformation leads to an expansion of the polarization region, while the polarization intensity value decrease. Under different observation angles, magnetic fields, fluid direction angles, and fluid velocity conditions, we also derive polarization images of corrected black holes. These key indicators not only affect the intensity of polarization but also the direction of polarization. We establish the relationship between polarization intensity and quantum correction deformation parameters, revealing a gradual decline in polarization intensity with reduced radius and an anti-polarization behavior induced by the progressive increase in deformation parameters at a constant radius. Our analysis may provide observational evidence for quantum effect of general relativity.
Motion of particles around a magnetically charged Euler–Heisenberg black hole with scalar hair and the Event Horizon Telescope
Authors: Theodosopoulos Dionysios P. , Karakasis Thanasis , Koutsoumbas George , Papantonopoulos Eleftherios 
Published: June 2024

AbstractWe study the motion of uncharged particles and photons in the background of a magnetically charged Euler–Heisenberg (EH) black hole (BH) with scalar hair. The spacetime can be asymptotically (A)dS or flat. After investigating particle motions around the BH and the behavior of the effective potential of the particle radial motion, we determine the contribution of the BH parameters to the geodesics. Photons follow null geodesics of an effective geometry induced by the corrections of the EH non-linear electrodynamics. Thus, after determining the effective geometry, we calculate the shadow of the BH. We also analyze in detail the case of extremal BH spacetimes and we find that the radius of both the event horizon and shadow exhibits discontinuities when varying with respect to either the magnetic charge or the scalar charge. These extremal scenarios exist for sufficiently small values of the EH parameter, and imply the formation of a second photon ring around the BH shadow. Upon comparing the theoretically calculated BH shadow to the images of the shadows of M87* and Sgr A* observed by the Event Horizon Telescope collaboration, we impose constraints on the BH parameters, namely the scalar hair ($$\nu $$
ν
), the magnetic charge ($$Q_{m}$$

Q
m

) and the EH parameter ($$\alpha $$
α
). For sufficiently large values of the EH parameter, our model is in agreement with the EHT observations for approximately every value for the BH magnetic charge.
MYTX-011: A pH-Dependent Anti–c-MET Antibody–Drug Conjugate Designed for Enhanced Payload Delivery to c-MET–Expressing Tumor Cells
Authors: Gera Nimish , Fitzgerald Kyle M. , Ramesh Vijay , Patel Purvi , Kanojia Deepak , Colombo Federico , Kien Lena , Aoyama Simon , Xu Lihui , Jean Jussekia , Deshpande Amit M. , Comb William C. , Chittenden Thomas , Fiske Brian P. 
Published: June 2024

Abstract
Advances in linker payload technology and target selection have been at the forefront of recent improvements in antibody–drug conjugate (ADC) design, leading to several approvals over the last decade. In contrast, the potential of novel ADC technologies to enhance payload delivery to tumors is relatively underexplored. We demonstrate that incorporation of pH-dependent binding in the antibody component of a c-mesenchymal–epithelial transition (MET)–targeting ADC (MYTX-011) can overcome the requirement for high c-MET expression on tumors, an innovation that has the potential to benefit a broader population of patients with lower c-MET levels. MYTX-011 drove fourfold higher net internalization than a non–pH-engineered parent ADC in non–small cell lung cancer (NSCLC) cells and showed increased cytotoxicity against a panel of cell lines from various solid tumors. A single dose of MYTX-011 showed at least threefold higher efficacy than a benchmark ADC in mouse xenograft models of NSCLC ranging from low to high c-MET expression. Moreover, MYTX-011 showed improved pharmacokinetics over parent and benchmark ADCs. In a repeat dose toxicology study, MYTX-011 exhibited a toxicity profile similar to other monomethyl auristatin E–based ADCs. These results highlight the potential of MYTX-011 for treating a broader range of patients with NSCLC with c-MET expression than other c-MET–targeting ADCs. A first-in-human study is ongoing to determine the safety, tolerability, and preliminary efficacy of MYTX-011 in patients with NSCLC (NCT05652868).
Abstract A025: KAT6A/B and Menin-MLL complexes coordinately regulate estrogen receptor-driven gene expression programs in breast cancer
Authors: Olsen Sarah Naomi , Anderson Bryn , Hatton Charles , Jeselsohn Rinath , Brown Myles , Toska Eneda , Armstrong Scott 
Published: June 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR012) of the Conference Program/Proceedings.
Citation Format: Sarah Naomi Olsen, Bryn Anderson, Charles Hatton, Rinath Jeselsohn, Myles Brown, Eneda Toska, Scott Armstrong. KAT6A/B and Menin-MLL complexes coordinately regulate estrogen receptor-driven gene expression programs in breast cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr A025.
Abstract IA010: Targeting genome instability in cancer: Translating synthetic lethal biology into the clinic
Authors: Zinda Michael 
Published: June 2024

Abstract
Membrane-associated tyrosine- and threonine-specific Cdc2-inhibitory kinase (PKMYT1) is a cell cycle regulatory kinase that inhibits CDK1/CyclinB activity, delaying entry into mitosis in tumor cells experiencing replication stress (RS). RS is frequently induced by genetic alterations that drive premature transition from G1 to S phase, promoting genome instability and creating a synthetic lethal (SL) relationship between these specific alterations and PKMYT1 inhibition. This relationship has been demonstrated preclinically and clinically with CCNE1 amplification as well as FBXW7 and PPP2R1A deleterious mutations. These genetic alterations are common across a range of tumors including ovarian, endometrial and colorectal cancers. On this basis, we developed lunresertib (RP-6306), a first-in-class, potent and selective oral PKMYT1 inhibitor currently being investigated in phase I clinical trials (NCT04855656, NCT05147272, NCT05147350). Here we discuss the translation of pre-clinical data to the clinical setting as both monotherapy and mechanistic combinations approaches.
Citation Format: Michael Zinda. Targeting genome instability in cancer: Translating synthetic lethal biology into the clinic [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Expanding and Translating Cancer Synthetic Vulnerabilities; 2024 Jun 10-13; Montreal, Quebec, Canada. Philadelphia (PA): AACR; Mol Cancer Ther 2024;23(6 Suppl):Abstract nr IA010.