bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the serial use of the myelofibrosis symptom assessment form for measuring symptomatic improvement
Authors: Mesa Ruben A. , Kantarjian Hagop , Tefferi Ayalew , Dueck Amylou , Levy Richard , Vaddi Kris , Erickson‐Viitanen Susan , Thomas Deborah A. , Cortes Jorge , Borthakur Gautam , Pardanani Animesh D. , Estrov Zeev , Verstovsek Srdan 
Published: April 2011

AbstractBACKGROUND:Symptomatic burden from constitutional symptoms, anemia, and splenomegaly‐related symptoms are common and morbidity inducing in patients with myelofibrosis (MF). The authors previously developed a MF‐specific instrument for capturing the burden of MF‐associated disease‐related symptoms, the Myelofibrosis Symptom Assessment Form.METHODS:The authors evaluated the usefulness of serial administration of the Myelofibrosis Symptom Assessment Form as an instrument for the assessment of symptomatic burden and improvement in conjunction with the therapeutic clinical trial of the open label phase 2 trial of the JAK1 and JAK2 inhibitor INCB018424 in patients with MF.RESULTS:The analysis cohort of 87 patients treated in this trial demonstrated that the instrument was comprehensive and sensitive to symptoms present at trial enrollment. In addition, baseline Myelofibrosis Symptom Assessment Form symptom scores correlated well with objective parameters such as splenomegaly and impaired performance status assessed by the 6‐minute walk test. Serial administration while on therapy with INCB018424 demonstrated the instrument to be sensitive to symptomatic change, and that improvements in symptoms correlated well with objective improvements in both weight loss and performance status (6‐minute walk test).CONCLUSIONS:The use of the Myelofibrosis Symptom Assessment Form in this phase 2 trial helped characterize the symptomatic improvements observed with use of INCB018424 in MF patients. In an era of many targeted therapies undergoing testing for MF with potential symptomatic benefit, the Myelofibrosis Symptom Assessment Form may provide a useful tool for objective symptomatic assessment and potentially allow some nonrandomized comparison between therapeutic agents. Cancer 2011;. © 2011 American Cancer Society.
The effect of streamflow reductions on aquatic habitat availability and fish and macroinvertebrate assemblages in coastal plain streams
Authors: Procopio Nicholas A. 
Published: April 2011

ABSTRACTThe purpose of this study was to estimate changes to aquatic habitat availability and fish and aquatic macroinvertebrate assemblages in coastal plain streams that may result from groundwater withdrawals. Hypothetical streamflow reductions of 5, 10, 20, and 30% of average annual streamflow and the 7‐day low flow were calculated for 14 study sites. Using study‐site streamflow and channel morphology data, relationships were developed to estimate five physical habitat metrics including average stream width, stream depth, stream cross‐sectional area, stream‐reach volume, and stream velocity. A second set of relationships was then developed to estimate the percentage reduction to each habitat metric under the hypothetical streamflow reduction scenarios. The average percentage decrease and variability of each habitat metric increased with successive streamflow reductions. Average percentage decreases in stream width, stream depth, stream cross‐sectional area, and stream‐reach volume were more pronounced for the reductions of average flow, whereas the average percentage decreases in stream velocity were more pronounced for the reductions of low flow. Models derived from a separate fish and macroinvertebrate study were used to estimate assemblage structure responses based on hypothetical reductions in average annual streamflow. The results of this study can be used to estimate the potential impact of groundwater withdrawals and subsequent streamflow reductions on available aquatic habitat and changes to fish and macroinvertebrate assemblages in coastal plain streams. Copyright © 2011 John Wiley & Sons, Ltd.
Modulation of human T‐cell functions by reactive nitrogen species
Authors: Kasic Tihana , Colombo Piergiuseppe , Soldani Cristiana , Wang Chiuhui M. , Miranda Elena , Roncalli Massimo , Bronte Vincenzo , Viola Antonella 
Published: April 2011

AbstractPrevious studies have suggested that T‐lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS). In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T‐cell signaling, activation, and migration. We found that short exposure of human T cells to RNS induced tyrosine phosphorylation of several proteins, including the CD3ζ chain of the TCR complex, and release of Ca2+ from intracellular stores. When the exposure to RNS was prolonged, T cells became refractory to stimulation, downregulated membrane receptors such as CD4, CD8, and chemokine receptors, and lost their ability to migrate in response to chemokines. Since substantial protein nitration, a hallmark of nitrative stress, was observed in various human cancers, intratumoral generation of RNS might represent a relevant mechanism for tumor evasion from immune surveillance.
Stabilin‐1/CLEVER‐1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages
Authors: Palani Senthil , Maksimow Mikael , Miiluniemi Mari , Auvinen Kaisa , Jalkanen Sirpa , Salmi Marko 
Published: April 2011

AbstractStabilin‐1/common lymphatic endothelial and vascular endothelial receptor‐1 (CLEVER‐1) is a multidomain protein present in lymphatic and vascular endothelial cells and type 2 immunosuppressive macrophages. In adults, stabilin‐1/CLEVER‐1 is a scavenging receptor and an adhesion molecule, but much less is known about its role during development. Here, we studied the expression and functions of macrophage stabilin‐1/CLEVER‐1 in human placenta and during human ontogeny. Using newly generated mAbs, we found that stabilin‐1/CLEVER‐1 is expressed on virtually all macrophages in term placenta, both in the decidua and in the placental villi. Placental stabilin‐1/CLEVER‐1 was involved in the scavenging of Ac‐LDL (acetylated low density lipoprotein) and in the uptake of fluorescently labeled model antigen OVA. siRNA‐mediated suppression of stabilin‐1/CLEVER‐1 altered the cytokine profile produced by placental macrophages. Stabilin‐1/CLEVER‐1 on placental macrophages mediated their adhesion to placental vessels and supported their transmigration through vascular endothelium. Finally, we found that stabilin‐1/CLEVER‐1 is induced very early in fetal macrophages, high endothelial venules, and lymphatic vessels in multiple lymphatic organs. Together, these data suggest that macrophage stabilin‐1/CLEVER‐1 can potentially regulate leukocyte migration and scavenging during the development of the placenta and fetus.
Two‐Phase Approach to High‐Quality, Oil‐Soluble, Near‐Infrared‐Emitting PbS Quantum Dots by Using Various Water‐Soluble Anion Precursors
Authors: Deng Dawei , Cao Jie , Xia Junfei , Qian Zhiyu , Gu Yueqing , Gu Zhongze , Akers Walter John 
Published: April 2011

AbstractColloidal PbS quantum dots (QDs) with tunable photoemission throughout the near‐infrared (NIR) region (ca. 750–1000 nm) were synthesized by a two‐phase approach. Here, oil‐soluble lead oleate formed by a reaction of lead acetate and oleic acid (OA, the capping agent) in n‐decane at 130 °C was used as lead precursor, and water‐soluble Na2S, thioacetamide (TAA), and thiourea, each having a different reactivity, were used as sulfur sources. When an n‐decane solution of lead precursor and an aqueous solution of sulfur precursor were mixed at the appointed temperature, oil‐soluble, near‐infrared‐emitting PbS QDs were achieved. In this study, we investigated the influence of the reactivity of water‐soluble sulfur sources on the synthesis of PbS QDs. The morphology and crystal structure of the as‐prepared PbS QDs were characterized by (high‐resolution) transmission electron microscopy (TEM), selected area electron diffraction (SAED), and X‐ray diffraction (XRD).
Solvent extraction of highly valuable oxygenated terpenes from lemon essential oil using a polypropylene membrane contactor: potential and limitations
Authors: Dupuy A. , Athes V. , Schenk J. , Jenelten U. , Souchon I. 
Published: April 2011

ABSTRACTIn this study, the technology of membrane contactors was assessed for the liquid–liquid extraction of highly valuable oxygenated terpenes from lemon essential oil using mixtures of water and ethanol as solvents (20–66% v/v ethanol). The main expected benefit of using membrane contactors in this application was the elimination of the phase separation step, which can be difficult in these types of systems, which are characterized by a low interfacial tension and the presence of natural surfactants. A commercially available polypropylene hollow fibre contactor (Liqui‐Cel® 2.5 × 8 with X30 fibres) was used in this study. Stabilizing the interface between the hydro‐alcoholic solvent and lemon essential oil in membrane pores proved difficult (breakthrough pressure below 0.2 bar), even with solvents containing only 20% v/v ethanol. This problem was probably due to defects in the membrane material such as the presence of large pores (up to 4 µm in diameter). Nonetheless, the hydro‐alcoholic extract remained emulsion free throughout extraction, considered to be an improvement since it eliminated the time‐consuming decantation step (process intensification). High mass transfer coefficients up to 1.08 × 10−6 m/s were obtained for the tracer of oxygenated terpenes and a solvent with 66% v/v ethanol. The membrane never represented more than 25% of the total resistance to mass transfer. We demonstrated the high potential of using membrane contactors for this application, provided that improvements were performed on membrane materials. Copyright © 2011 John Wiley & Sons, Ltd.
Study on umami taste: the MSG taste‐enhancing activity of N2‐alkyl and N2‐alkanoyl‐5′‐guanylic acids having a sulfoxide group inside the N2‐substituent
Authors: Morelli Carlo F. , Manitto Paolo , Speranza Giovanna 
Published: April 2011

ABSTRACTN2‐alkyl and N2‐alkanoyl derivatives of guanosine 5′‐phosphate bearing a sulfoxide group into the side chain (3b,e; 4b) were synthesized and tested for their synergistic effect with monosodium‐l‐glutamate (MSG), which is the prototypical substance imparting umami taste to savoury‐based foods. Capacities to enhance the taste intensity of MSG were estimated (as γ values) through subjective comparisons of MSG/5′‐nucleotide mixtures in water with appropriate solutions of MSG alone, followed by statistical treatment (Probit method) of the resulting responses. The synergistic activity of each sulfoxide toward MSG resulted to be lower than that of the corresponding sulfide. Copyright © 2011 John Wiley & Sons, Ltd.
Can oil diversify away the unpriced risk of a portfolio?
Authors: Cifarelli Giulio , Paladino Giovanna 
Published: April 2011

ABSTRACTThe growing presence of financial operators in the oil market has brought about the diffusion of techniques—such as feedback trading—which lead to departures of prices from their fundamental values and increase their variability. Oil price changes are here associated with changes in stocks, bonds and effective USD exchange rate. The feedback trading mechanism is combined with an ICAPM scheme. This original model is estimated in a four asset CCC GARCH non‐linear framework, where the risk premium and the feedback trading components of the conditional means are multiplicative functions of the system's conditional variances and covariances. The empirical analysis, which encompasses the 2008–2009 financial crisis, identifies a structural change in the year 2000. From then on oil returns tend to become more reactive to the remaining assets of the model and feedback trading more pervasive. A comparison is drawn between three and four asset minimum variance portfolios in the two subperiods, 1992–1999 and 2000–2009. Indeed, the trade‐off between risk and returns—measured here by the average return per unit of risk index—indicates that in the last decade, oil diversifies away the empirical risk of our portfolio. Copyright © 2011 John Wiley & Sons, Ltd.
Incorporating spiritual beliefs into a cognitive model of worry
Authors: Rosmarin David H. , Pirutinsky Steven , Auerbach Randy P. , Björgvinsson Thröstur , Bigda‐Peyton Joseph , Andersson Gerhard , Pargament Kenneth I. , Krumrei Elizabeth J. 
Published: April 2011

AbstractCognitive theory and research have traditionally highlighted the relevance of the core beliefs about oneself, the world, and the future to human emotions. For some individuals, however, core beliefs may also explicitly involve spiritual themes. In this article, we propose a cognitive model of worry, in which positive/negative beliefs about the Divine affect symptoms through the mechanism of intolerance of uncertainty. Using mediation analyses, we found support for our model across two studies, in particular, with regards to negative spiritual beliefs. These findings highlight the importance of assessing for spiritual alongside secular convictions when creating cognitive‐behavioral case formulations in the treatment of religious individuals. © 2011 Wiley Periodicals, Inc. J Clin Psychol 67:1–10, 2011.
Training competent psychologists in the field of child maltreatment
Authors: Damashek Amy , Balachova Tatiana , Bonner Barbara 
Published: April 2011

AbstractChild maltreatment is a serious threat to children's physical and psychological well‐being; therefore, it is critically important to develop high‐quality educational programs to train psychologists in effectively addressing child abuse and neglect. Various health care disciplines and areas within the field of psychology have established competencies as a guide for student training curricula; however, none have been established for the area of child maltreatment. The present article presents training competencies for the field of child maltreatment that have been developed from a program designed to train psychology graduate students to practice and conduct research in child maltreatment. The competencies have been divided into eight core areas including assessment, treatment, multidisciplinary collaboration, advocacy, ethics, research, research ethics, and professional development. © 2011 Wiley Periodicals, Inc. J Clin Psychol 67:1–6, 2011.
The modified wells score accurately excludes pulmonary embolus in hospitalized patients receiving heparin prophylaxis
Authors: Bahia Amit , Albert Richard K. 
Published: April 2011

AbstractBACKGROUND:The usefulness of the Wells score has not been assessed in hospitalized patients receiving prophylactic heparin.METHODS:Retrospective, observational study of hospitalized patients receiving prophylactic heparin who underwent contrast‐enhanced chest computed tomography (CT) for a concern of pulmonary embolism (PE) more than 2 days after admission. Patients with contraindications to, or interruptions in, prophylactic heparin were excluded. The modified (eg, dichotomous) Wells score was retrospectively calculated by reviewing each patient's record. Requesting a d‐dimer was taken to mean that alternate diagnoses were of equal or greater likelihood than acute PE.RESULTS:From January 2006 through December 2007, 286 patients met inclusion criteria. Pulmonary embolus diagnosed by CT was present in 20 patients (7%). The sensitivity, specificity, positive and negative predictive values of a Wells score ≥4.0 were 95%, 27%, 9% and 99%, respectively. A d‐dimer was ordered in 70 of the 74 PE‐unlikely cases, was elevated in 67, and falsely positive in all but 1.CONCLUSIONS:The prevalence of PE in hospitalized patients receiving prophylactic heparin is lower than in cohorts from which the Wells prediction criteria were derived and validated. A modified Wells score <4 safely excludes PE in such patients and reduces the need for CT. D‐dimer testing adds nothing to the evaluation. Journal of Hospital Medicine 2011;. © 2011 Society of Hospital Medicine.
An alternative to R2 for assessing linear models of effect size
Authors: Aloe Ariel M. , Becker Betsy Jane , Pigott Therese D. 
Published: April 2011

AbstractReviewers often use regression models in meta‐analysis (‘meta‐regressions’) to examine the relationships between effect sizes and study characteristics. In this paper, we propose and illustrate the use of an index (R) that expresses the amount of variance in the outcome that is explained by the meta‐regression model. The values of R2 obtained from the standard computer output for linear models of effect size in the meta‐analysis context are typically too small, because the typical R2 considers sampling variance to be unexplained whereas in meta‐analysis it can be quantified. Although the idea of removing the unexplainable variance from the estimator of variance accounted for in meta‐analysis is not new (Cook et al., 1992; Raudenbush, 1994) we explicitly define four estimators of variance explained, and illustrate via two examples that the typical R2 obtained in a linear model of effect size is always lower than our indices. Thus, the typical R2 underestimates the explanatory power of linear models of effect sizes. Our four estimators improve upon typical weighted R2 values. Copyright © 2011 John Wiley & Sons, Ltd.
Use of quality control charts for detection of outliers and temporal trends in cumulative meta‐analysis
Authors: Kulinskaya Elena , Koricheva Julia 
Published: April 2011

AbstractCumulative meta‐analysis (CMA) aims to aggregate accumulating evidence. Essentially a visual tool, CMA should be supplemented by formal statistical methods for assessment of the significance of the accumulating evidence, and for detection of temporal trends in effect sizes. These methods should also take into account multiple testing inherent in CMA. We review the existing methods for detection of temporal trends in effect sizes and suggest a new approach, namely the use of standard quality control (QC) charts, in particular X charts and CUSUM charts, to detect possible outliers and trends over time. We discuss the application of the QC charts to four popular measures of effect size: the odds ratios, the relative risks, the correlation coefficients and the standardized mean differences. Applications of QC charts are illustrated by three meta‐analysis examples from medicine, ecology and evolutionary biology. Copyright © 2011 John Wiley & Sons, Ltd.
Cancer therapy based on oncogene addiction
Authors: McCormick Frank 
Published: April 2011

AbstractTumor cells contain multiple mutations, yet they often depend on continued expressed of a single oncoprotein for survival. Targeting these proteins has led to dramatic responses. Unfortunately, patients usually progress, through drug resistance or adaptive resistance through reprogramming of signaling networks. The Ras‐MAPK pathway provides examples of these successes and failures, and has revealed unexpected degrees of oncogene addiction and signaling complexity that are likely to be useful lessons for the future of targeted therapy. J. Surg. Oncol. 2011;103:464–467. © 2011 Wiley‐Liss, Inc.
Detection and prognostic impact of micrometastasis in colorectal cancer
Authors: Sirop Saad , Kanaan Mohammed , Korant Alpesh , Wiese David , Eilender David , Nagpal Sunil , Arora Madan , Singh Trevor , Saha Sukamal 
Published: April 2011

AbstractReview of literature was performed on studies with prognostic impact of micrometastasis in colorectal cancer. Among 16 studies included, micrometastasis was detected in 26.5% of patients. Most analysis revealed that micrometastasis carries a poorer prognosis compared to node negative disease (NND). The results of those studies were compared with our pilot study of 109 patients with colon cancer, showing improved prognosis of micrometastasis after being upstaged and treated with chemotherapy when compared with NND. J. Surg. Oncol. 2011;103:534–537. © 2011 Wiley‐Liss, Inc.
Experimental models to study lymphatic and blood vascular metastasis
Authors: Chen Lu , Hann Byron , Wu Lily 
Published: April 2011

AbstractAs a model system for the understanding of human cancer, the mouse has proved immensely valuable. Indeed, studies of mouse models have helped to define the nature of cancer as a genetic disease and demonstrated the causal role of genetic events found in tumors. As an experimental platform, they have provided critical insight into the process of tumor metastasis in the lymphovascular system. Once viewed with skepticism, mouse models are now an integral arm of basic and clinical cancer research. The use of a genetically tractable organism that shares organ systems and an immense degree of genetic similarity to humans provides a means to examine multiple features of human disease. Mouse models enable development and testing of new approaches to disease prevention and treatment, identification of early diagnostic markers and novel therapeutic targets, and an understanding of the in vivo biology and genetics of tumor initiation, promotion, progression, and metastasis. This review summarizes recent mouse models for lymphangiogenesis and the process of lymphovascular metastasis, focusing on the use of the cornea as an experimental platform for lymphangiogenesis in inflammation and immunity, and on the use of molecular and viral vector mediated imaging and to identify and monitor lymph node metastases of prostate cancer. J. Surg. Oncol. 2011;103:475–483. © 2011 Wiley‐Liss, Inc.
Diagnostic and therapeutic imaging for cancer: Therapeutic considerations and future directions
Authors: Roach Mack , Alberini Jean‐Louis , Pecking Alain Paul , Testori Alessandro , Verrecchia Francesco , Soteldo Javier , Ganswindt Ute , Joyal John L. , Babich John W. , Witte Russell S. , Unger Evan , Gottlieb Ronald 
Published: April 2011

AbstractAs cancer treatment cost soar and the mantra for “personalized medicine” grows louder, we will increasingly be searching for solutions to these diametrically opposed forces. In this review we highlight several exciting novel imaging strategies including MRI, CT, PET SPECT, sentinel node, and ultrasound imaging that hold great promise for improving outcomes through detection of lymph node involvement. We provide clinical data that demonstrate how these evolving strategies have the potential to transform treatment paradigms. J. Surg. Oncol. 2011;103:587–601. © 2011 Wiley‐Liss, Inc.
Prostate cancer stem cells and their potential roles in metastasis
Authors: Li Hangwen , Tang Dean G. 
Published: April 2011

AbstractMost solid tumors have now been reported to contain stem cell‐like cells called cancer stem cells (CSCs). These cells are endowed with high tumorigenic capacity and may be the cells that drive tumor formation, maintain tumor homeostasis, and mediate tumor metastasis. Since these self‐renewing cancer cells may be the sole population to develop a primary tumor, it is predicted that CSCs may also represent the lethal seeds of metastasis, as supported by a flurry of recent studies on the relationship between CSCs and metastasis. Herein, we summarize current knowledge of stem/progenitor cells and CSCs, especially in the context of normal human prostate and prostate cancer. We further update the recently gained knowledge on the involvement of CSCs in metastasis. We also discuss the fundamental influence of tumor microenvironment on the manifestation of CSCs and metastasis. Finally, we discuss the clinical implication of CSC‐based therapy. J. Surg. Oncol. 2011;103:558–562. © 2011 Wiley‐Liss, Inc.