bluuebunny/crossref_metadata_2025_split huggingface dataset:
QSPR Analysis of the Patterns Scheme Parameters for the Prediction of Monomer Reactivity Ratios
Authors: Yi Bing , Tan Zhengde , Yu Xinliang 
Published: February 2011

AbstractTwo quantitative structure‐property relationship (QSPR) models were developed to correlate radical chemical structure and the reactivity parameters u and v, respectively, of the revised patterns scheme for the prediction of monomers reactivity ratios. The radicals with structure C1H3–C2HR3· (formed from C1H2C2HR3 and H·) were calculated using the UB3LYP density functional theory (DFT) methods with a 6‐31G(d) basis set. The calculated quantum chemical descriptors were used to construct QSPR models for the reactivity parameters (u, v) by applying the genetic algorithm (GA) method, together with multiple linear regression (MLR) analysis. Correlation coefficients for the training sets are 0.941 for the parameter u and 0.947 for the parameter v; correlation coefficients for the test sets are 0.947 for u and 0.934 for v. The results suggest that calculating quantum chemical descriptors from radicals to develop models for parameters u and v is feasible.
Crystal Structure, Thermal Decomposition Behaviors and Sensitivity Properties of a Novel Energetic Compound [Co(DAT)6] (ClO4)2
Authors: Qi Shuyuan , Li Zhimin , Zhou Zunning , Cui Yan , Zhang Guotao , Zhang Tonglai , Zhang Jianguo , Yang Li 
Published: February 2011

AbstractA novel energetic coordination compound [Co(DAT)6](ClO4)2 has been synthesized by using 1,5‐diaminotetrazole (DAT) as a ligand and its structure has been characterized using X‐ray single crystal diffraction, elemental analysis and FT‐IR spectroscopy. The central cobalt(II) cation is coordinated by six N atoms from six DAT molecules to form a six‐coordinated and distorted octahedral structure. Di‐dimension layer structure was formed by the extensive intermolecular hydrogen bonds between DAT ligands and ClO−4 anions along a‐axis and b‐axis. Thermal decomposition mechanism of [Co(DAT)6](ClO4)2 was investigated based on differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and Fourier transform infrared (FT‐IR) spectra. The kinetic parameters of the first exothermic process were studied by applying the Kissinger's and Ozawa‐Doyle's methods. Additionally, the sensitivities of this complex were tested. The results of all the studies show that [Co(DAT)6](ClO4)2 has an extreme potential application as an energetic material.
Synthesis, Crystal Structure and DNA Cleavage Activity of a Ternary Copper(II) Complex of Dipyrido[3,2‐d:2′,3′‐f]‐quinoxaline and Glycine
Authors: Zhang Shouchun , Chun Xiaogai , Chen Yun , Zhou Jianliang 
Published: February 2011

AbstractA ternary copper(II) complex, [Cu(Dpq)(Gly)(H2O)]·NO3·1.5H2O (Dpq=dipyrido[3,2‐d:2′,3′‐f]quinoxaline, Gly=glycine), has been synthesized and structurally characterized. The complex crystallized in a triclinic system with space group P‐1, a=6.6979(9) Å, b=7.6351(10) Å, c=18.980(2) Å, α=85.815(2) °, β=88.182(2) °, γ=71.203(2) °. The five‐coordinate copper(II) center is a distorted square pyramid. Absorption spectra, fluorescence spectra and CD spectra showed that there were interactions between the copper complex and DNA through a groove binding mode. The complex exhibited efficient DNA cleavage activity at micromolar concentration in the presence of ascorbate with hydroxyl radicals as the active species.
Ligand‐free Suzuki‐Miyaura Cross‐Coupling Reactions of Aryltriazenes with Arylboronic Acids
Authors: Nan Guangming , Zhu Fanghua , Wei Zhijun 
Published: February 2011

AbstractThe boron trifluoride induced Suzuki‐Miyaura cross‐coupling of aryltriazenes with arylboronic acids catalyzed by Pd(OAc)2 without added ligands has been achieved for the first time. The reactions performed at room temperature under an argon atmosphere give biaryls in good to excellent yields. It is noteworthy that the reactions were conducted under mild and ligand‐free conditions.
Flavonol Glycoside from Psorospermum androsaemifolium
Authors: Poumale Poumale Herve Martia , Krebs Hans Christoph , Amadou Dawe , Shiono Yoshihito , Guedem Alphonsine Nkapwa , Komguem Justin , Ngadjui Bonaventure Tchaleu , Randrianasolo Rivoarison 
Published: February 2011

AbstractA new flavonol glycoside, 3′‐(4′''‐(3′''',4′'''‐dihydroxyphenoxy)‐2′''‐hydroxyphenoxy)acanthophorin B (1a) together with 3′‐(2′'',4′''‐dihydroxyphenoxy)acanthophorin B (1), acanthophorin B (2), vismiaquinone (3), rheochrysidin (3a), lupeol acetate and fatty acid were isolated from the chloroform extract of the stem bark of Psorospermum androsaemifolium Baker (Clusiaceae). The structure of 1a was determined on the basis of detailed spectroscopic analysis and comparison with the literature. Compounds 1a and 3a showed moderate antimicrobial activity.
2D‐Π‐A Type Organic Dyes Based on N,N‐Dimethylaryl Amine and Rhodamine‐3‐acetic Acid for Dye‐sensitized Solar Cells
Authors: Tang Kai , Liang Mao , Liu Yongkang , Sun Zhe , Xue Song 
Published: February 2011

AbstractThree organic dyes XS17–19 based on N,N‐dimethylaryl amine and rhodamine‐3‐acetic acid moieties are designed and synthesized. These dyes were applied into nanocrystalline TiO2 dye‐sensitized solar cells through standard operations, showing strong absorption bands at around 320–650 nm, and exhibiting broad IPCE responses. Cell based on XS17 gave a Jsc of 3.7 mA/cm2, an open circuit voltage of 550 mV, and a fill factor of 0.68, corresponding to an overall conversion efficiency of 1.4%. The low overall conversion efficiency is due to the modest IPCE and Voc values, which mainly stem from the acceptor of rhodanine‐3‐acetic acid.
Synthesis of Novel Spiro Thiazolo[3,2‐a][1,3,5]triazines via 1,3‐Dipolar Cycloaddition of Azomethine Ylide
Authors: Li Xiaofang , Liu Haochong , Zheng Aiting , Li Zhikui , Li Guobin , Yu Xianyong , Yi Pinggui 
Published: February 2011

AbstractThe 1,3‐dipolar cycloaddition of an azomethine ylide generated by a decarboxylative route from sarcosine and acenaphthenequinone to 7‐arylmethylidene‐3‐aryl‐3,4‐dihydro‐2H‐thiazolo[3,2‐a][1,3,5]triazin‐6(7H)‐ones afforded novel dispiro[acenaphthylene‐1,2′‐pyrrolidine]‐3′,7′ ′‐[1,3]thiazolo[3,2‐a][1,3,5]triazines in moderate yields. The structures of the products were determined and characterized thoroughly by NMR, MS, IR, elemental analysis and X‐ray crystallographic analysis. The results of experiment indicated that this 1,3‐dipolar cycloaddition proceeded with high stereoselectivity and regioselectivity.
Implantable Mechanical Circulatory Support: Demystifying Patients With Ventricular Assist Devices and Artificial Hearts
Authors: Shah Keyur B. , Tang Daniel G. , Cooke Richard H. , Harton Suzanne , Flattery Maureen , Katlaps Gundars J. , Kasirajan Vigneshwar , Hess Michael L. 
Published: February 2011

AbstractEngineering advancements have expanded the role for mechanical circulatory support devices in the patient with heart failure. More patients with mechanical circulatory support are being discharged from the implanting institution and will be seen by clinicians outside the immediate surgical or heart‐failure team. This review provides a practical understanding of device design and physiology, general troubleshooting, and limitations and complications for implantable left ventricular assist devices (pulsatile‐flow and continuous‐flow pumps) and the total artificial heart. © 2011 Wiley Periodicals, Inc.Dr. Vigneshwar Kasirajan and Dr. Michael Hess receives a consulting honorarium from SynCardia Systems, Inc. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
The utility of endobronchial ultrasound‐guided transbronchial needle aspiration biopsy in the diagnosis of mediastinal lymphoproliferative disorders
Authors: Marshall Carrie B. , Jacob Betsy , Patel Shobhana , Sneige Nour , Jimenez Carlos A. , Morice Rudolph C. , Caraway Nancy 
Published: February 2011

AbstractBACKGROUND:Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) biopsy is routinely used to stage lung cancer; however, its usefulness in diagnosing lymphoproliferative disorders has not been well established. In this retrospective study, we determined the utility of EBUS‐TBNA in evaluating mediastinal lymphadenopathy in patients with suspected lymphoproliferative disorders.METHODS:The authors searched the pathology database at their institution to identify all patients who had undergone EBUS‐TBNA biopsy for possible lymphoproliferative disorders. The cytologic diagnoses were correlated with concurrent and subsequent biopsy findings and clinical follow‐up data.RESULTS:Of 886 lymph nodes evaluated by EBUS‐TBNA biopsy, 91 nodes from 33 patients (23 men and 10 women) were eligible. Fourteen patients had a history of lymphoma. Adequate material for diagnosis was obtained in 31 of 34 procedures (1 patient had 2 procedures). The cytologic diagnoses of the 31 adequate procedures included 19 with benign disease (8 reactive lymph nodes and 11 granulomatous inflammation), 8 with lymphoma (2 large B‐cell, 2 small lymphocytic, 2 Hodgkin, 1 mantle cell, and 1 T‐cell lymphoblastic), 2 with cells suspicious for Hodgkin lymphoma, and 2 cases with atypical cells.CONCLUSIONS:EBUS‐TBNA proved to be useful for evaluating mediastinal lymphadenopathy in patients with suspected lymphoproliferative disorders. Its use may decrease the need for invasive diagnostic procedures. Immediate assessment is valuable in these cases because of the need to triage material for immunophenotyping or other studies to determine optimal and clinically meaningful diagnoses. Cancer (Cancer Cytopathol) 2011. © 2011 American Cancer Society
A FRET Sensor for Non‐Invasive Imaging of Amyloid Formation in Vivo
Authors: Kaminski Schierle Gabriele S. , Bertoncini Carlos W. , Chan Fiona T. S. , van der Goot Annemieke T. , Schwedler Stefanie , Skepper Jeremy , Schlachter Simon , van Ham Tjakko , Esposito Alessandro , Kumita Janet R. , Nollen Ellen A. A. , Dobson Christopher M. , Kaminski Clemens F. 
Published: February 2011

AbstractMisfolding and aggregation of amyloidogenic polypeptides lie at the root of many neurodegenerative diseases. Whilst protein aggregation can be readily studied in vitro by established biophysical techniques, direct observation of the nature and kinetics of aggregation processes taking place in vivo is much more challenging. We describe here, however, a Förster resonance energy transfer sensor that permits the aggregation kinetics of amyloidogenic proteins to be quantified in living systems by exploiting our observation that amyloid assemblies can act as energy acceptors for variants of fluorescent proteins. The observed lifetime reduction can be attributed to fluorescence energy transfer to intrinsic energy states associated with the growing amyloid species. Indeed, for α‐synuclein, a protein whose aggregation is linked to Parkinson′s disease, we have used this sensor to follow the kinetics of the self‐association reactions taking place in vitro and in vivo and to reveal the nature of the ensuing aggregated species. Experiments were conducted in vitro, in cells in culture and in living Caenorhabditis elegans. For the latter the readout correlates directly with the appearance of a toxic phenotype. The ability to measure the appearance and development of pathogenic amyloid species in a living animal and the ability to relate such data to similar processes observed in vitro provides a powerful new tool in the study of the pathology of the family of misfolding disorders. Our study confirms the importance of the molecular environment in which aggregation reactions take place, highlighting similarities as well as differences between the processes occurring in vitro and in vivo, and their significance for defining the molecular physiology of the diseases with which they are associated.
Liver lesions in children and adolescents: Cytopathologic analysis and clinical correlates in 44 cases
Authors: Laiq Zenab , Bishop Justin A. , Ali Syed Z. 
Published: February 2011

AbstractThe role of fine needle aspiration (FNA) as a first‐line diagnostic modality is well‐established for neoplastic and nonneoplastic liver masses in adults. However, cytopathologic analysis of such lesions in children and adolescents has not been well studied. An 18‐year retrospective review of the cytopathology archives at The Johns Hopkins Hospital identified 44 cases of hepatic FNA in children and adolescents (i.e., 21 years and younger). The cytopathologic material was reviewed and correlated with subsequent surgical pathology diagnoses and/or clinical follow‐up. Among the 44 FNAs studied, 40 (90.9%) were deemed diagnostic for evaluation and 4 (9.1%) were nondiagnostic. Twenty four (60%) of the diagnostic FNAs were neoplasms, 10 (25%) were nonneoplastic lesions, and 6 (15%) were “atypical” or “suspicious.” There were 21 (87.5%) malignant and 3 (12.5%) benign tumors. Among the malignant cases, metastases/secondary tumors accounted for 12 (54.5%) followed by hepatocellular carcinoma (HCC)—7 (38.1%). The types of metastatic/secondary neoplasms were Wilms tumor (2), germ cell tumor (2), acute leukemias (2), and miscellaneous others (6). Among the nonneoplastic lesions focal nodular hyperplasia was most common—4 (40%). Among the “atypical” cases, 4 (66.6%) turned out to be benign on follow‐up, 2 were HCC, and 1 was Hodgkin lymphoma. Immunoperoxidase (IPOX) studies were done in 20 (45.5%) cases to confirm the cytopathologic diagnoses. Overall, FNA showed a sensitivity of 95.2% and a specificity of 100% for a malignant diagnosis. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Endometriosis of sigmoid colon mimicking malignant tumor diagnosed by intraoperative imprint cytology
Authors: Ohsaki Hiroyuki , Nakamura Muneo , Arie Keiji , Hirakawa Eiichiro , Haba Reiji , Norimatsu Yoshiaki 
Published: February 2011

AbstractA case of endometriosis of the sigmoid colon on imprint cytology from an intraoperative biopsy is discussed. Cytologic specimens showed sheets or tubular epithelial clusters and stromal fragments. The epithelial cell nuclei were small and round to ovoid with finely granular chromatin and inconspicuous nucleoli. The background showed a few scattered spindle‐type stromal cells without pigment‐laden histiocytes. A definitive diagnosis of endometriosis can be based on cytology, provided that the cytologic findings are interpreted in the appropriate clinical context. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
An atypical morphologic presentation of coccidioides spp. in fine‐needle aspiration of lung
Authors: Schuetz Audrey N. , Pisapia David , Yan Jiong , Hoda Rana S. 
Published: February 2011

AbstractInfection due to Coccidioides spp., a dimorphic fungal pathogen, usually presents as a chronic pulmonary disease, occasionally with pulmonary nodules. On cytology, large spherules filled with endospores are typically seen. We report an unusual case of coccidioidomycosis in a 39‐year‐old female from an area nonendemic for Coccidioides and without other known risk factors for infection. Fine‐needle aspiration of the patient's cavitary lung lesion revealed Coccidioides spp., which demonstrated atypical delicate septate hyphal forms and chains of conidia, with none of the large spherules typical of Coccidioides spp. Atypical hyphal and other forms of Coccidioides spp. have been reported in several studies, primarily from biopsy or tissue resection specimens. However, this is the first case to our knowledge that the organism has presented solely as conidial and atypical hyphal forms in an aspirated specimen. Pathologists who are unfamiliar with this atypical hyphal formation may misdiagnose the organism as several different fungi, including Aspergillus spp. or Fusarium spp. It is important to differentiate among fungi, as antifungal treatments may vary. Cytologists should be aware of the diverse morphologies demonstrated by Coccidioides spp. and include this organism in their differential diagnosis, even in patients seemingly devoid of pertinent risk factors. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Fractal dimension of chromatin texture of squamous intraepithelial lesions of cervix
Authors: Dey Pranab , Banik Tarak 
Published: February 2011

AbstractThe aim of this study was to explore the role of fractal dimension (FD) of chromatin texture in routinely stained Papanicolaou's smears and to distinguish the different grades of cervical intraepithelial lesions and normal cervical cells. We selected 14 each cases of normal, low grade cervical intra epithelial lesions (LSIL), and high‐grade cervical intra epithelial lesions (HSIL) of Papanicolaou's stained cervical smears. Fractal dimension of the pseudo three‐dimensional grey image of the nuclear chromatin was measured in 140 nuclei of each group. Mean FD of the normal cases, LSIL cases, and HSIL cases were 2.4225 ± 0.06410, 2.5159 ± 0.03291, and 2.5905 ± 0.06840, respectively. ANOVA test showed significant differences of mean FD in all these three groups (P < 0.000). Fractal dimension of the chromatin texture is easy to perform and can be done in routinely stained Papanicolaou's smear. It is reproducible and gives valuable information about the chromatin texture of the nucleus. In future, this promising variable can be incorporated along with other image morphometric features for accurate classification of dysplastic cells in cervical smear. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Dedifferentiation and the role of sall4 in reprogramming and patterning during amphibian limb regeneration
Authors: Neff Anton W. , King Michael W. , Mescher Anthony L. 
Published: February 2011

AbstractA central feature of epimorphic regeneration during amphibian limb regeneration is cellular dedifferentiation. Two questions are discussed. First, what is the origin and nature of the soluble factors involved in triggering local cellular and tissue dedifferentiation? Secondly, what role does the key stem cell transcription factor Sall4 play in reprogramming gene expression during dedifferentiation? The pattern of Sall4 expression during Xenopus hindlimb regeneration is consistent with the hypothesis that Sall4 plays a role in dedifferentiation (reprogramming) and in maintaining limb blastema cells in an undifferentiated state. Sall4 is involved in maintenance of ESC pluripotency, is a major repressor of differentiation, plays a major role in reprogramming differentiated cells into iPSCs, and is a component of the stemness regulatory circuit of pluripotent ESCs and iPSCs. These functions suggest Sall4 as an excellent candidate to regulate reprogramming events that produce and maintain dedifferentiated blastema cells required for epimorphic regeneration. Developmental Dynamics 240:979–989, 2011. © 2011 Wiley‐Liss, Inc.
Nodal‐mediated epigenesis requires dynamin‐mediated endocytosis
Authors: Ertl Robin P. , Robertson Anthony J. , Saunders Diane , Coffman James A. 
Published: February 2011

AbstractNodal proteins are diffusible morphogens that drive pattern formation via short‐range feedback activation coupled to long‐range Lefty‐mediated inhibition. In the sea urchin embryo, specification of the secondary (oral‐aboral) axis occurs via zygotic expression of nodal, which is localized to the prospective oral ectoderm at early blastula stage. In mid‐blastula stage embryos treated with low micromolar nickel or zinc, nodal expression expands progressively beyond the confines of this localized domain to encompass the entire equatorial circumference of the embryo, producing radialized embryos lacking an oral‐aboral axis. RNAseq analysis of embryos treated with nickel, zinc, or cadmium (which does not radialize embryos) showed that several genes involved in endocytosis were similarly perturbed by nickel and zinc but not cadmium. Inhibiting dynamin, a GTPase required for receptor‐mediated endocytosis, phenocopies the effects of nickel and zinc, suggesting that dynamin‐mediated endocytosis is required as a sink to limit the range of Nodal signaling. Developmental Dynamics 240:704–711, 2011. © 2011 Wiley‐Liss, Inc.
Dynamic analysis of BMP‐responsive smad activity in live zebrafish embryos
Authors: Laux Derek W. , Febbo Jennifer A. , Roman Beth L. 
Published: February 2011

AbstractBone morphogenetic proteins (BMPs) are critical players in development and disease, regulating such diverse processes as dorsoventral patterning, palate formation, and ossification. These ligands are classically considered to signal via BMP receptor‐specific Smad proteins 1, 5, and 8. To determine the spatiotemporal pattern of Smad1/5/8 activity and thus canonical BMP signaling in the developing zebrafish embryo, we generated a transgenic line expressing EGFP under the control of a BMP‐responsive element. EGFP is expressed in many established BMP signaling domains and is responsive to alterations in BMP type I receptor activity and smad1 and smad5 expression. This transgenic Smad1/5/8 reporter line will be useful for determining ligand and receptor requirements for specific domains of BMP activity, as well as for genetic and pharmacological screens aimed at identifying enhancers or suppressors of canonical BMP signaling. Developmental Dynamics 240:682–694, 2011. © 2011 Wiley‐Liss, Inc.
Sulfated is a negative feedback regulator of wingless in Drosophila
Authors: You Jia , Belenkaya Tatyana , Lin Xinhua 
Published: February 2011

AbstractDrosophila Wingless (Wg) acts as a morphogen to control pattern formation in a concentration dependent manner. Previous studies demonstrated important roles of heparan sulfate proteoglycans (HSPGs) in controlling Wg signaling and distribution. Here, we examined the role of Sulfated (Sulf1), a Drosophila homolog of vertebrate heparan sulfate 6‐O endosulfatase, in Wg signaling and distribution. We show that sulf1 is specifically up‐regulated by Wg signaling in the wing disc. We found that expression of Wg target gene senseless (sens) was elevated in the sulf1 mutant wing discs. Sulf1 also negatively regulate extracellular levels of Wg. Genetic interaction experiments indicate that Wg antagonist Notum may work synergistically with Sulf1 to restrict Wg signaling, and Dally, a member of Drosophila HSPGs, is a potential target of Sulf1. Our results demonstrate that sulf1 is a novel Wg target gene and by a feedback mechanism, it negatively regulated Wg signaling and distribution in vivo. Developmental Dynamics 240:640–648, 2011. © 2011 Wiley‐Liss, Inc.
Dynamic smad‐mediated BMP signaling revealed through transgenic zebrafish
Authors: Collery Ross F. , Link Brian A. 
Published: February 2011

AbstractBone morphogenic protein (BMP) signaling is fundamental to development, injury response, and homeostasis. We have developed transgenic zebrafish that report Smad‐mediated BMP signaling in embryos and adults. These lines express either enhanced green fluorescent protein (eGFP), destabilized eGFP, or destabilized Kusabira Orange 2 (KO2) under the well‐characterized BMP Response Element (BRE). These fluorescent proteins were found to be expressed dynamically in regions of known BMP signaling including the developing tail bud, hematopoietic lineage, dorsal eye, brain structures, heart, jaw, fins, and somites, as well as other tissues. Responsiveness to changes in BMP signaling was confirmed by observing fluorescence after activation in an hsp70:bmp2b transgenic background or by inhibition in an hsp70:nog3 background. We further demonstrated faithful reportage by the BRE transgenic lines following chemical repression of BMP signaling using an inhibitor of BMP receptor activity, dorsomorphin. Overall, these lines will serve as valuable tools to explore the mechanisms and regulation of BMP signal during embryogenesis, in tissue maintenance, and during disease. Developmental Dynamics 240:712–722, 2011. © 2011 Wiley‐Liss, Inc.