bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetic tracking in the operation room using the da Vinci® telemanipulator is feasible
Authors: Kenngott H. G. , Wegner I. , Neuhaus J. , Nickel F. , Fischer L. , Gehrig T. , Meinzer H. P. , Müller-Stich B. P. 
Published: March 2012

Abstract
In recent years, robotic assistance for surgical procedures has grown on a worldwide scale, particularly for use in more complex operations. Such operations usually require meticulous handling of tissue, involve a narrow working space and limit the surgeon’s sense of orientation in the human body. Improvement in both tissue handling and working within a narrow working space might be achieved through the use of robotic assistance. Soft tissue navigation might improve orientation by visualizing important target and risk structures intraoperatively, thereby possibly improving patient outcome. Prerequisites for navigation are its integration into the surgical workflow and accurate localization of both the instruments and patient. Magnetic tracking allows for good integration but is susceptible to distortion through metal or electro-magnetic interference, which may be caused by the operation table or a robotic system. We have investigated whether magnetic tracking can be used in combination with the da Vinci® (DV) telemanipulator in terms of stability and precision. We used a common magnetic tracking system (Aurora®, NDI Inc.) with the DV in a typical operation setup. Magnetic field distortion was evaluated using a measuring facility, with the following reference system: without any metal (R), operation table alone (T), DV in standby (D) and DV in motion (Dm). The maximum error of the entire tracking volume for R, T, D and Dm was 9.9, 32.8, 37.9 and 37.2 mm, respectively. Limiting the tracking volume to 190 mm (from cranial to caudal) resulted in a maximum error of 4.0, 8.3, 8.5 and 8.9 mm, respectively. When used in the operation room, magnetic tracking shows high errors, mainly due to the operation table. The target area should be limited to increase accuracy, which is possible for most surgical applications. The use of the da Vinci® telemanipulator only slightly aggravates the distortion and can thus be used in combination with magnetic tracking systems.
Fibrodysplasia ossificans progressiva
Authors: Stefanova I. , Grünberg C. , Gillessen-Kaesbach G. 
Published: March 2012

Zusammenfassung
Bei der Fibrodysplasia ossificans progressiva (FOP) handelt es sich um eine sehr seltene, autosomal-dominant vererbbare Erkrankung, die durch Ausbildung von heterotopen Ossifikationen charakterisiert ist, welche zu einer ausgeprägten Mobilitätseinschränkung führen. Angeborene Fehlbildungen von Großzehen im Sinne von Hypoplasie und fibularer Deviation werden bei den meisten Patienten beschrieben. Eine Hypoplasie der Daumen besteht bei etwa der Hälfte der Patienten. Als genetische Ursache der FOP wurden heterozygote Mutationen im ACVR1-Gen identifiziert. Wir berichten über die klinischen und molekulargenetischen Daten von 25 eigenen Patienten (3 bereits veröffentlicht) und weiteren 47 Patienten aus der Literatur mit bekannten Mutationen, bei denen klinische Daten vorlagen und stellen eine Genotyp-Phänotyp-Korrelation dar.
Data interoperability in the future of middleware
Authors: Paolucci Massimo , Souville Berrand 
Published: March 2012

Abstract
Data interoperability is one of the main problems of system interoperability. Indeed, it is estimated that the cost of data interoperability ranges in the billions of dollars every year. The traditional approach to data interoperability is to define mappings between different data structures and different data formats. Whereas this is surely a very important part of the problem, it is not its only aspect. Often systems need to aggregate data coming from different systems, and to reason and derive conclusions from these data. In this paper, we will review the efforts performed in the semantic web to unlock this problem and highlight trends and pitfalls.
A new type of absorbable barbed suture for use in laparoscopic myomectomy
Authors: Angioli Roberto , Plotti Francesco , Montera Roberto , Damiani Patrizio , Terranova Corrado , Oronzi Irma , Luvero Daniela , Scaletta Giuseppe , Muzii Ludovico , Panici Pierluigi B. 
Published: March 2012

AbstractObjectiveTo compare effectiveness, feasibility, and suturing time required between an absorbable barbed wire (V‐Loc) uterine suture and a classic continuous suture with intracorporeal knots among women undergoing laparoscopic myomectomy.MethodsFrom January 2010 to February 2011, women with single symptomatic intramural myoma were prospectively enrolled in a single‐center study at a university hospital in Rome, Italy. A control group with characteristics meeting the criteria for study inclusion was retrospectively identified from the hospital databases. In the prospective group uterine wall defects were closed with V‐Loc suture, whereas in the control group they were closed by classical continuous suture with intracorporeal knots. Data were analyzed via Student t test, Mann–Whitney U test, and Fisher exact test.ResultsThe mean operative time was shorter in the V‐Loc (51 ± 18.1 min) than in the control (58 ± 17.8 min) group. Suturing time was significantly lower in the V‐Loc than in the control (9.9 ± 4.3 versus 15.8 ± 4.7 min; P = 0.0004) group. Both intraoperative bleeding and drop in hemoglobin were significantly lower in the V‐Loc group (P = 0.0076 and P = 0.0176, respectively).ConclusionUse of a barbed suture may aid surgeons during laparoscopic suturing by reducing operative time, suturing time, and blood loss.
The Transcript-Centric Mutations in Human Genomes
Authors: Cui Peng , Lin Qiang , Ding Feng , Hu Songnian , Yu Jun 
Published: March 2012

Abstract
Since the human genome is mostly transcribed, genetic variations must exhibit sequence signatures reflecting the relationship between transcription processes and chromosomal structures as we have observed in unicellular organisms. In this study, a set of 646 ubiquitous expression-invariable genes (EIGs) which are present in germline cells were defined and examined based on RNA-sequencing data from multiple high-throughput transcriptomic data. We demonstrated a relationship between gene expression level and transcript-centric mutations in the human genome based on single nucleotide polymorphism (SNP) data. A significant positive correlation was shown between gene expression and mutation, where highly-expressed genes accumulate more mutations than lowly-expressed genes. Furthermore, we found four major types of transcript-centric mutations: C→T, A→G, C→G, and G→T in human genomes and identified a negative gradient of the sequence variations aligning from the 5′ end to the 3′ end of the transcription units (TUs). The periodical occurrence of these genetic variations across TUs is associated with nucleosome phasing. We propose that transcript-centric mutations are one of the major driving forces for gene and genome evolution along with creation of new genes, gene/genome duplication, and horizontal gene transfer.
Gene2DGE: A Perl Package for Gene Model Renewal with Digital Gene Expression Data
Authors: Tang Xiaoli , Deng Libin , Zhang Dake , Lin Jiari , Wei Yi , Zhou Qinqin , Li Xiang , Li Guilin , Liang Shangdong 
Published: March 2012

Abstract
For transcriptome analysis, it is critical to precisely define all the transcripts across the whole genome. More and more digital gene expression (DGE) scannings have indicated the presence of huge amount of novel transcripts in addition to the known gene models. However, almost all these studies still depend crucially on existing annotation. Here, we present Gene2DGE, a Perl software package for gene model renewal with DGE data. We applied Gene2DGE to the mouse blastomere transcriptome, and defined 98,532 read-enriched regions (RERs) by read clustering supported by more than four reads for each base pair. Taking advantage of this ab initio method, we refined 2,104 exonic regions (4% of a total of 48,501 annotated transcribed regions) with remarkable extension into un-annotated regions (&gt;50 bp). For 5% of uniquely mapped reads falling within intron regions, we identified 13,291 additional possible exons. As a result, we renewed 4,788 gene models, which account for 39% of a total of 12,277 transcribed genes. Furthermore, we identified 12,613 intergenic RERs, suggesting the possible presence of novel genes outside the existing gene models. In this study, therefore, we have developed a suitable tool for renewal of known gene models by ab initio prediction in transcriptome dissection. The Gene2DGE package is freely available at http://bighapmap.big.ac.cn/.
On the Flow Structures Under a Partially Inundated Bridge Deck
Authors: Lin C. , Kao M.-J. , Hsieh S.-C. , Lo L.-F. , Raikar R. V. 
Published: March 2012

ABSTRACTThis paper presents the flow structure under a partially inundated bridge deck measured by using particle image velocimetry (PIV) and flow visualization techniques. The approaching flow was subcritical having Froude number F in the range 0.12 ∼ 0.55. The proximity ratio Pr (= ratio of clearance below the bridge deck h to the total depth of deck D) was varied from 0.57 to 2. Depending upon the Froude number F and proximity ratio Pr, four types of flow structures under the bridge deck were recognized. In flow Type I, the water surface elevation on the downstream side of bridge deck is slightly lower than the counterpart on the upstream side, and the shear layer formed at the bottom of upstream girder continuously fluctuates and touches soffit of all girders. In the case of flow Type II, the water surface on downstream side of bridge deck is lower than that on the upstream side and the shear layer originating from the upstream girder impinges near the third cavity between girders. However, in both the cases, the cavities between the girders are completely occupied by vortices. On the contrary, in the cases of flow Type III and flow Type IV, the flow is separated from the upstream girder edge. However, in flow Type III, the separated flow impinges on successive girders and cavities are partially filled by water; while in flow Type IV, the flow is totally separated from the deck bottom like orifice flow. The phenomena of vortex formation within the cavities are discussed for the cases of flow Type I and flow Type II. Also, for the vertical distribution of mean streamwise velocity in the shear layer below bridge deck, the nonlinear regression equations are developed. Using the distributions of measured mean streamwise velocity within the shear layer below the bridge deck at different streamwise distances, the similarity profile is obtained. The mean velocity deficit (usl – usu) and representative thickness bs are considered as the appropriate characteristic velocity and length scales for developing similarity profile. The proposed characteristic scales provided unique similarity profiles having promising regression coefficient. The similarity profile proposed is suitable for more general case of bridge deck having different bridge girders and even for rectangular block without girder. Further, the turbulence characteristics for the flow below the bridge deck are also presented.
Nonlinear Dynamic Analysis of Micro Cantilever Beam Under Electrostatic Loading
Authors: Liu C.-C. , Yang S.-C. , Chen C.-K. 
Published: March 2012

ABSTRACTA hybrid differential transformation / finite difference scheme is used to analyze the complex nonlinear behavior of an electrostatically-actuated micro cantilever beam which high aspect ratios (length/width). The validity of the proposed method is confirmed by comparing the numerical results obtained for the tip displacement and pull-in voltage of the cantilever beam with the analytical and experimental results presented in the literature. The hybrid scheme is then applied to analyze both the steady-state and the dynamic deflection behavior of the cantilever beam as a function of the applied voltage. Overall, the results confirm that the hybrid method provides an accurate and computationally-efficient means of analyzing the complex nonlinear behavior of both the current micro cantilever beam system and other micro-scale electrostatically-actuated structures.
Iron supplementation is positively associated with increased serum ferritin levels in 9-month-old Danish infants
Authors: Gondolf Ulla Holmboe , Tetens Inge , Michaelsen Kim F. , Trolle Ellen 
Published: March 2012

Fe deficiency is still common in infancy, even in affluent societies, and has prompted Fe fortification of food products and use of Fe supplements in many populations. In the present study, we tested the hypothesis that Fe status among 9-month-old infants following the Danish Fe supplementation recommendation (>400 ml Fe-fortified formula or 8 mg Fe/d) is associated with more favourable levels of Fe status indicators compared to those not following the recommendation. A random sample of 9-month-old infants living in Copenhagen was established and 312 healthy term infants were examined at 9·1 (sd0·3) months of age. Blood samples were available from 278 infants. Overall, twenty infants (7·8 %) had Fe deficiency (serum ferritin < 12 μg/l) and < 1 % had Fe deficiency anaemia (serum ferritin < 12 μg/l and Hb < 100 g/l). Serum ferritin was positively associated with birth weight (P < 0·001), intake of fortified formula and follow-on formula (P = 0·001), and female sex (P < 0·001). Cow's milk intake and length of exclusive breast-feeding were negatively associated with Hb levels (P = 0·013 andP < 0·001). Serum ferritin levels were significantly higher (P < 0·0001) and transferrin receptor (TfR) was significantly lower (P = 0·003) among infants (n188) meeting the Fe supplementation recommendation compared to those (n67) not meeting the recommendation. No significant difference between these two groups was found for Hb. In conclusion, this study confirmed that Fe status of infants following the Danish Fe supplementation recommendation was significantly associated with increased serum ferritin and decreased levels of TfR indicating more favourable Fe status, compared to infants not following the recommendation.
Drinking water is a significant predictor ofBlastocystisinfection among rural Malaysian primary schoolchildren
Authors: ABDULSALAM AWATIF M. , ITHOI INIT , AL-MEKHLAFI HESHAM M. , AHMED ABDULHAMID , SURIN JOHARI , MAK JOON-WAH 
Published: March 2012

SUMMARYBlastocystisinfection has a worldwide distribution especially among the disadvantaged population and immunocompromised subjects. This study was carried out to determine the prevalence and the association ofBlastocystisinfection with the socio-economic characteristics among 300 primary schoolchildren, living in rural communities in Lipis and Raub districts of Pahang state, Malaysia. Stool samples were collected and examined for the presence ofBlastocystisusing direct smear microscopy afterin vitrocultivation in Jones' medium. The overall prevalence ofBlastocystisinfection was found to be as high as 25·7%. The prevalence was significantly higher among children with gastrointestinal symptoms as compared to asymptomatic children (x2=4·246;P=0·039). Univariate and multivariate analyses showed that absence of a piped water supply (OR=3·13; 95% CI=1·78, 5·46;P<0·001) and low levels of mothers’ education (OR=3·41; 95% CI=1·62, 7·18;P<0·01) were the significant predictors ofBlastocystisinfection. In conclusion,Blastocystisis prevalent among rural children and the important factors that determine the infection were the sources of drinking water and mothers' educational level. Interventions with provision of clean water supply and health education especially to mothers are required.
Intrusions in trauma and psychosis: information processing and phenomenology
Authors: Marks E. M. , Steel C. , Peters E. R. 
Published: March 2012

BackgroundIntrusions are common symptoms of both post-traumatic stress disorder (PTSD) and schizophrenia. It has been suggested that an information processing style characterized by weak trait contextual integration renders psychotic individuals vulnerable to intrusive experiences. This ‘contextual integration hypothesis’ was tested in individuals reporting anomalous experiences in the absence of a need for care.MethodTwenty-six low schizotypes and 23 individuals reporting anomalous experiences were shown a traumatic film with and without a concurrent visuospatial task (VST). Participants rated post-traumatic intrusions for frequency and form, and completed self-report measures of information processing style. It was predicted that, because of their weaker trait contextual integration, the anomalous experiences (AE) group would (1) exhibit more intrusions following exposure to the trauma film, (2) display intrusions characterized by more PTSD qualities and (3) show a greater reduction of intrusions with the concurrent VST.ResultsAs predicted, the AE group reported a lower level of trait contextual integration and more intrusions than the low schizotypes, both immediately after watching the film and during the following 7 days. Their post-traumatic intrusive memories were more PTSD-like (more intrusive, vivid and associated with emotion). The VST had no effect on the number of intrusions in either group.ConclusionsThese findings provide some support for the proposal that weak trait contextual integration underlies the development of intrusions within both PTSD and psychosis.
Predictors of suicide attempts in patients with borderline personality disorder over 16 years of prospective follow-up
Authors: Wedig M. M. , Silverman M. H. , Frankenburg F. R. , Reich D. Bradford , Fitzmaurice G. , Zanarini M. C. 
Published: March 2012

BackgroundIt is clinically important to understand the factors that increase the likelihood of the frequent and recurrent suicide attempts seen in those with borderline personality disorder (BPD). Although several studies have examined this subject in a cross-sectional manner, the aim of this study was to determine the most clinically relevant baseline and time-varying predictors of suicide attempts over 16 years of prospective follow-up among patients with BPD.MethodTwo-hundred and ninety in-patients meeting Revised Diagnostic Interview for Borderlines (DIB-R) and DSM-III-R criteria for BPD were assessed during their index admission using a series of semistructured interviews and self-report measures. These subjects were then reassessed using the same instruments every 2 years. The generalized estimating equations (GEE) approach was used to model the odds of suicide attempts in longitudinal analyses, controlling for assessment period, yielding an odds ratio (OR) and 95% confidence interval (CI) for each predictor.ResultsNineteen variables were found to be significant bivariate predictors of suicide attempts. Eight of these, seven of which were time-varying, remained significant in multivariate analyses: diagnosis of major depressive disorder (MDD), substance use disorder (SUD), post-traumatic stress disorder (PTSD), presence of self-harm, adult sexual assault, having a caretaker who has completed suicide, affective instability, and more severe dissociation.ConclusionsThe results of this study suggest that prediction of suicide attempts among borderline patients is complex, involving co-occurring disorders, co-occurring symptoms of BPD (self-harm, affective reactivity and dissociation), adult adversity, and a family history of completed suicide.
Activation Work: Policy Programme Administration or Professional Service Provision?
Authors: VAN BERKEL RIK , VAN DER AA PAUL 
Published: March 2012

AbstractThis article focuses on the design of frontline work in public agencies involved in the delivery of activation programmes and services. More specifically, it raises the following questions: should we think of activation work as an administrative function or as a form of professional service provision? And does the design of activation work matter in terms of the effectiveness of activation services? In answering these questions, the article provides a meta-analysis of two strands of literature. First, we analyse the available literature reporting on studies of activation frontline work and its organisation and management in public agencies responsible for delivering activation programmes. Secondly, we look at those studies of the effectiveness of activation that focus on the impact of characteristics of frontline work and its organisation and management on activation policy outcomes. We conclude that although the desirability of a professional design of activation work meets relatively wide support among scholars, the feasibility of this professionalisation project is highly contested. In addition, the debate on the nature of the activation profession has only just started. Finally, evaluation studies show that activation work characteristics do affect the outcomes of activation programmes. Against this background, we conclude that a more prominent place of activation work on the research agenda of social policy scholars is recommendable.
Reaching the Hard-to-Reach: Conceptual Puzzles and Challenges for Policy and Practice
Authors: MACKENZIE MHAIRI , REID MAGGIE , TURNER FIONA , WANG YINGYING , CLARKE JULIA , SRIDHARAN SANJEEV , PLATT STEPHEN , O'DONNELL CATHERINE 
Published: March 2012

AbstractThe concept of systematic inequalities in social and health outcomes has come to form part of contemporary policy discourse. This rhetoric is deployed even in the face of policy decisions widely viewed as iniquitous. Moreover, there is a widespread view, expressed across the political spectrum, that those in more deprived circumstances are less likely than their more affluent counterparts to be in receipt of optimal public services. Such individuals and communities are variously described as excluded, disadvantaged, underserved or hard to reach. Across countries and policy domains the term ‘hard to reach’ is used to refer to those deemed not to be in optimal receipt of public sector services which are intended to increase some aspect of material, social or physical wellbeing. It is increasingly used in health policy documents which aim to address health inequalities. However, it is an ill-defined and contested term. The purpose of this paper is two-fold. First, it offers a critical commentary on the concept of hard-to-reachness and asks: who are viewed as hard to reach and why? Second, using a case-study of a Scottish health improvement programme that explicitly aims to reach and engage the ‘hard to reach’ in preventive approaches to cardiovascular disease, it tests the policy and practice implications of the concept. It finds that a lack of conceptual clarity leads to ambiguous policy and practice and argues for possible theoretical refinements.
The voice of others: Identity, alterity and gender normativity among gay men in Israel
Authors: Levon Erez 
Published: March 2012

AbstractThis article presents an analysis of a slang variety, calledoxtšit, as it is described and used by a cohort of gay men in Israel. Unlike many previous analyses of gay slang, I argue that the men described do not use the variety to help construct and affirm an alternative gay identity, but rather that they use it as a form of in-group mockery through which normative and nonnormative articulations of Israeli gay male sexuality are delineated. It is suggested that this discussion has implications for sociolinguistic understandings of “groupness” more broadly, and particularly the relationship between macro-level social categories (like “gay”) and individual lived experience. (Gay slang, Israel, vari-directional voicing, identity/alterity)*