bluuebunny/crossref_metadata_2025_split huggingface dataset:
On a multistable dynamic model of behavioral and perceptual infant development
Authors: Frank T.D. , van der Kamp J. , Savelsbergh G.J.P. 
Published: March 2010

AbstractIn this theoretical work, we treat behavioral and perceptual issues on an equal footing and examine the emergence of mutually exclusive behavioral patterns and perceptual variables during infant development from the perspective of multistable competitive dynamic systems. Accordingly, behavioral modes and modes of perception compete with each other for activation. One and only one mode survives the mode–mode competition, which accounts for the incompatibility of modes being considered. However, the winning behavioral or perceptual state is not predefined. Rather, we argue that during particular stages of maturation multiple modes coexist for the same set of developmental, body‐scaled, and environmental parameters or constraints. The winning behavioral or perceptual state depends on these parameters as well as on initial conditions as operationalized in terms of previously performed behaviors or utilized perceptual stimuli. We give explicit examples of our approach and address the emergence of two‐handed grasping and catching movements and the emergence of monocular and binocular vision during infant development. In particular, we propose that the emergence of midline crossing movements in 3‐ to 6‐month‐old infants involves two independent but interaction control parameters: a body‐scaled and a developmental one. Likewise, we argue that the onset of binocularity in infants involves two independent but interaction control parameters: a developmental and an environmental one. © 2010 Wiley Periodicals, Inc. Dev Psychobiol 52: 352–371, 2010.
Identification of a Van der Woude syndrome mutation in the cleft palate 1 mutant mouse
Authors: Stottmann R.W. , Bjork B.C. , Doyle J.B. , Beier D.R. 
Published: March 2010

AbstractMutations in Interferon Regulatory Factor 6 (IRF6) have been identified in two human allelic syndromes with cleft lip and/or palate: Van der Woude (VWS) and Popliteal Pterygium syndromes (PPS). Furthermore, common IRF6 haplotypes and single nucleotide polymorphisms (SNP) alleles are strongly associated with nonsyndromic clefting defects in multiple ethnic populations. Mutations in the mouse often provide good models for the study of human diseases and developmental processes. We identified the cleft palate 1 (clft1) mouse mutant in a forward genetic screen for phenotypes modeling human congenital disease. In the clft1 mutant, we have identified a novel missense point mutation in the mouse Irf6 gene, which confers an amino acid alteration that has been found in a VWS family. Phenotypic comparison of clft1 mutants to previously reported Irf6 mutant alleles demonstrates the Irf6clft1 allele is a hypomorphic allele. The cleft palate seen in these mutants appears to be due to abnormal adhesion between the palate and tongue. The Irf6clft1 allele provides the first mouse model for the study of an etiologic IRF6 missense mutation observed in a human VWS family. genesis 48:303–308, 2010. © 2010 Wiley‐Liss, Inc.
p89c‐Myb is not required for fetal or adult hematopoiesis
Authors: Baker Stacey J. , Kumar Atul , Reddy E. Premkumar 
Published: March 2010

AbstractThe c‐myb gene encodes two proteins, termed p75 and p89. Of these, the larger isoform is transcribed from an alternatively spliced message that contains an additional exon, exon 9A. Disruption of the c‐myb locus in mice results in embryonic lethality due to defective hematopoiesis and in the adult, tissue‐specific inactivation of c‐myb in hematopoietic tissues blocks differentiation along several lineages. The c‐myb knock‐out mouse models described thus far result in the disruption of both the p75 and p89 isoforms, making it impossible to assign a definitive role to p89c‐Myb in development and hematopoiesis. We have therefore generated a null‐mutant mouse where exon 9A has been systemically deleted that results in the absence of only the p89‐myb transcript and protein. Unlike disruption of both forms of the c‐myb gene, loss of only the p89‐encoding isoform does not have any deleterious effects on mammalian hematopoiesis and development. genesis 48:309–316, 2010. © 2010 Wiley‐Liss, Inc.
Photoactivated Biological Activity of Transition‐Metal Complexes
Authors: Schatzschneider Ulrich 
Published: March 2010

AbstractPhotochemical activation is a very attractive way to achieve precise spatial and temporal control of the biological action of transition‐metal complexes that behave as inactive “prodrugs” in the dark. A significant amount of work has been devoted to metal complexes that act on DNA. In this area, focus has been on ruthenium and rhodium polypyridyl compounds, but copper, iron, cobalt, and vanadium complexes also find increasing application as photoactivable DNA cleaving agents, with excitation sometimes even possible in the near IR region. Most often, the activity of these systems is based on the formation of reactive radical species. Another promising approach is the photochemical generation of covalent DNA binders from inactive precursors, as, for example, by some platinum(IV) compounds. The photolytic liberation of biologically active small molecules from inactive metal complex precursors has also become the target of recent research efforts and complements work on purely organic “caged” compounds. The significant progress made on light‐induced liberation of neurotransmitters as well as small molecule messengers like nitric oxide (NO) or carbon monoxide (CO) is also summarized here.
Quadrane Sesquiterpenes: Natural Sources, Biology, and Syntheses
Authors: Presset Marc , Coquerel Yoann , Rodriguez Jean 
Published: March 2010

AbstractQuadranes, discovered with the isolation of (–)‐quadrone in 1978, are biologically active naturally occurring sesquiterpenes featuring a distinctive set of bi‐ to tetracyclic ring systems. The available data for this family of natural products, including isolation data, biosynthetic considerations, a comprehensive compilation of the reported biological activities, and an exhaustive survey of the synthetic work in this area so far, are critically analyzed.
Simple, One‐Pot, and Facile Synthesis of Angularly Fused [6‐7‐5], [6‐7‐6], [6‐7‐7], and [6,7] Ring Systems Using Baylis–Hillman Acetates
Authors: Basavaiah Deevi , Aravindu Kunche , Kumar Katta Santosh , Reddy Kanumuri Ramesh 
Published: March 2010

AbstractA simple, convenient, and one‐pot synthesis of angularly fused [6‐7‐5], [6‐7‐6], [6‐7‐7], and [6,7] carbocyclic ring systems from Baylis–Hillman acetates through a strategy involving alkylation, formation of a vinyl chloride, and intramolecular cyclization (Friedel–Crafts or Michael reaction) is described.
Decoupling CE and ESI for a more robust interface with MS
Authors: Maxwell E. Jane , Zhong Xuefei , Zhang Hong , van Zeijl Nikita , Chen David D. Y. 
Published: March 2010

AbstractAn interface for CE‐ESI‐MS that decouples both the electrical and the solution flow rate requirements of the separation and ionization processes is presented. The interface uses a tapered and beveled stainless steel hollow needle surrounding the separation capillary terminus so that the inside of the electrode acts as the CE outlet vial and the outside tip acts as the electrospray emitter. No capillary pre‐treatment is required, enabling the use of capillaries with any type of surface modification. A chemical modifier solution is introduced through a second capillary connected to the needle via a tee junction and can be used to improve the compatibility of the CE BGE with electrospray. The flow rate of modifier solution can be as low as 0.1 μL/min, much less than that in a typical sheath‐flow interface, thus minimizing dilution of the CE effluent in order to maximize sensitivity. The presence of the modifier solution also allows the use of neutral‐coated capillaries for protein analysis by CE‐MS without using an assisting pressure, despite the absence of EOF under these conditions. The interface is easily integrated into a commercial CE instrument, such that all operations can be carried out by the automated controls. Compared with a commercial sheath‐flow CE‐MS interface operating under optimized conditions, LODs for amino acids were, on average, improved fivefold.
Analysis of methylated melamines in reaction mixtures by CZE‐MS
Authors: Himmelsbach Markus , Schmid Thomas , Buchberger Wolfgang , Schwarzinger Clemens , List Manuela 
Published: March 2010

AbstractA fast and reliable method based on CZE coupled to Q‐TOF MS for the analysis of methylated melamines is presented. Experiments with UV detection were performed using BGE containing formic acid and TFA to optimize electrophoretic conditions and to achieve baseline separation. Employing a TFA‐based electrolyte containing 80% ACN and MS detection, nine different methyl melamines were determined in real samples, which were produced by catalytic hydrogenation of melamine/formaldehyde reaction mixtures. The use of a Q‐TOF MS resulted in LOD better than 0.01 mg/L for all compounds and high mass accuracy with mass errors lower than 2.3 ppm.
French adaptation of the eating disorder recovery self‐efficacy questionnaire (EDRSQ): Psychometric properties and conceptual overview
Authors: Couture Stéphanie , Lecours Serge , Beaulieu‐Pelletier Genevieve , Philippe Frederick L. , Strychar Irene 
Published: March 2010

AbstractHigh prevalence of Eating Disorders (EDs) and poor treatment outcome rates have urged research in the assessment of EDs. Self‐efficacy is a key motivational factor in the recovery from EDs. A self‐report measure, the Eating Disorder Recovery Self‐Efficacy Questionnaire (EDRSQ), was recently developed to assess confidence in adopting healthy eating behaviours and in maintaining a realistic body image. The objectives of this study were to (a) translate the EDRSQ to French (EDRSQ‐F), (b) assess the psychometric properties of this French version, and (c) establish normative data for a non‐clinical sample. Participants were 203 undergraduate women. They completed the EDRSQ‐F and measures of ED symptoms, depression and self‐esteem. A confirmatory factor analysis (CFA) revealed a bi‐factorial structure. Both scales demonstrated evidence of reliability and theoretically consistent evidence of construct validity. Findings support the validity of the EDRSQ‐F and suggest it is a useful instrument for the assessment of EDs. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.
Polyhalogenated aromatic hydrocarbons and metabolites: Relation to circulating thyroid hormone and retinol in nestling bald eagles (Haliaeetus leucocephalus)
Authors: Cesh Lillian S. , Elliott Kyle H. , Quade Susan , McKinney Melissa A. , Maisoneuve France , Garcelon David K. , Sandau Court D. , Letcher Robert J. , Williams Tony D. , Elliott John E. 
Published: March 2010

AbstractPolyhalogenated aromatic hydrocarbons are global contaminants that are often considered to be endocrine disruptors and include 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (p,p′-DDE), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ethers (PBDEs). The present study examined these compounds and their hydroxylated metabolites or analogues and relationships with circulating thyroid hormones and retinols in plasma from nestling and adult bald eagles in British Columbia, Canada, and California, USA. We also compared our results with published data. Thyroxine (T4) decreased with ∑PCB and CB153 in nestling bald eagles, which was congruent with results from nine of 14 other published avian laboratory and field studies. Free thyroid hormone levels also decreased with CB-153 and hydroxylated PCBs (OH-PCBs). Retinol increased with CB118 and CB180 in nestling eagles, decreased with OH-PCBs in a subset of nestlings, and decreased in 7 of 12 PCB published studies. Thyroxine decreased with p,p′-DDE for nestlings and with data reported in one of five other published studies. In our samples, plasma retinol, triiodothyronine (T3), and T4 were independent of ∑PBDEs, whereas ∑OH-PBDEs were weakly but significantly correlated with increases in T3 and retinol. Adult bald eagles showed no relationship between contaminants and thyroid hormones, which is consistent with other studies of long-lived birds, perhaps because adult birds have time to adjust to contaminant levels. Measurement of circulating thyroid hormones appears to be a more useful biomarker than retinols, given the more consistent response of T4 to PCBs here and reported in the literature. We conclude that current environmental exposures to PCBs in British Columbia and in southern California are associated with significant decreases in T4, suggesting a potential negative effect on the endocrine system of nestling bald eagles. Environ. Toxicol. Chem. 2010;29:1301–1310. © 2010 SETAC
Clinical signs of photodamage are associated with basal cell carcinoma multiplicity and site: A 16‐year longitudinal study
Authors: Richmond‐Sinclair Naomi M. , Pandeya Nirmala , Williams Gail M. , Neale Rachel E. , van der Pols Jolieke C. , Green Adèle C. 
Published: March 2010

AbstractAlthough sun exposure is known to be associated with basal cell carcinoma (BCC), it is not known what determines multiple occurrences of BCCs among sporadically affected individuals or why BCCs develop on uncommonly sun‐exposed body sites like the trunk. In a prospective community‐based skin cancer study in Queensland, Australia, we studied all participants who experienced a histologically confirmed BCC from 1992 to 2007. Sun exposure history was monitored, and dermatologists documented phenotype at baseline and signs of photodamage over the study period. Anatomic sites of all incident BCCs were recorded. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression. Of 401 participants who developed a new BCC during the 16 years of follow‐up, 232 (58%) developed more than 1. Male sex (OR = 2.5, 95% CI 1.5–5.3) and age 60 or over (OR = 4.2, 95% CI 1.5–11.8) but not skin type were associated with highest BCC counts among those affected. Participants with high numbers of solar keratoses were most likely to experience the highest BCC counts overall (OR = 4.3, 95% CI 1.4–13.5). Moreover, occurrences of BCC on the trunk (OR = 3.3, 95% CI 1.4–7.6) and on the limbs (OR = 3.7, 95% CI 2.0–7.0) were strongly associated with high numbers of solar keratoses on these sites, respectively. Among those newly affected by BCC, chronic cutaneous sun damage predicts those who will be affected by more than 1 BCC, while chronic sun damage on the trunk and limbs predicts BCC occurrence on the trunk and limbs, respectively.
Effect of the correction for noncompliance and contamination on the estimated reduction of metastatic prostate cancer within a randomized screening trial (ERSPC section Rotterdam)
Authors: Kerkhof Melissa , Roobol Monique J. , Cuzick Jack , Sasieni Peter , Roemeling Stijn , Schröder Fritz H. , Steyerberg Ewout W. 
Published: March 2010

AbstractThe European Randomized study of Screening for Prostate Cancer (ERSPC) has recently reported a 20% reduction in death from prostate cancer in a population‐based prostate cancer screening (core age group: 55–69 years of age). The effect of screening may be diluted by noncompliance in the screening arm and contamination by PSA testing in the control arm. The purpose is to analyze the effect of prostate cancer screening on the incidence of metastatic prostate cancer, both with and without adjustment for noncompliance and contamination. We analyzed the occurrence of metastases in 42,376 men aged 55–75 years who were randomized in the Rotterdam section of the ERSPC between 1993 and 1999. Contamination adjustment was based on follow‐up findings and questionnaire data from all men in the control group who developed prostate cancer and from a random sample of 291 men without cancer who had a PSA test. Prostate cancer screening significantly reduced the occurrence of metastatic prostate cancer in the intention‐to‐screen analysis [RR 0.75, 95% CI 0.59–0.95, p = 0.02] and more so in adjusted analyses; contamination adjusted RR 0.73, 95% CI 0.56–0.96; noncompliance adjusted RR 0.72, 95% CI 0.55–0.95 and fully adjusted analysis RR 0.68, 95% CI 0.49–0.94, p = 0.02. In the population of ERSPC Rotterdam (N = 42,376 men), screening reduces the risk to be diagnosed with metastatic prostate cancer considerably on population level, an effect which is even more pronounced in men who are in fact screened.
Measuring forecast uncertainty by disagreement: The missing link
Authors: Lahiri Kajal , Sheng Xuguang 
Published: March 2010

AbstractUsing a standard decomposition of forecast errors into common and idiosyncratic shocks, we show that aggregate forecast uncertainty can be expressed as the disagreement among the forecasters plus the perceived variability of future aggregate shocks. Thus the reliability of disagreement as a proxy for uncertainty will be determined by the stability of the forecasting environment and the length of the forecast horizon. Using density forecasts from the Survey of Professional Forecasters, we find direct evidence in support of our hypothesis. Our results support the use of GARCH‐type models, rather than theex postsquared errors in consensus forecasts, to estimate theex antevariability of aggregate shocks as a component of aggregate uncertainty. Copyright © 2010 John Wiley & Sons, Ltd.
Gold nanorods as new nanochromophores for photothermal therapies
Authors: Ratto Fulvio , Matteini Paolo , Centi Sonia , Rossi Francesca , Pini Roberto 
Published: March 2010

AbstractResults and perspectives on the biomedical exploitation of gold nanorods with plasmon resonances in the near infrared window are reported. The authors describe experimental studies of laser‐activated nanoparticles in the direct welding of connective tissues, which may become a valuable technology in biomedicine. In particular, colloidal gold nanorods excited by diode laser radiation at 810 nm were used to mediate functional photothermal effects and weld eye's lens capsules and arteries. The preparation of biopolymeric matrices including gold nanorods is also described, as well as preliminary tests for their application in the closure of wounds in vessels and tendons. Finally, the use of these nanoparticles for future applications in the diagnosis, imaging and therapy of cancer is discussed. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A regional scale assessment of land use/land cover and climatic changes on water and energy cycle in the upper Midwest United States
Authors: Mishra Vimal , Cherkauer Keith A. , Niyogi Dev , Lei Ming , Pijanowski Bryan C. , Ray Deepak K. , Bowling Laura C. , Yang Guoxiang 
Published: March 2010

AbstractThis study examines the relative impact of regional land‐cover/land‐use patterns and projected future climate change on hydrologic processes. Historic, present and projected future land cover data were used to drive the variable infiltration capacity (VIC) model using observed meteorological forcing data for 1983–2007 over Wisconsin (USA). The current and projected future (year 2030) land cover data were developed using the land transformation model (LTM). The VIC model simulations were driven using downscaled and bias‐corrected projected future climate forcing from three different Intergovernmental Panel for Climate Change (IPCC) AR4 general circulation models (GCMs): HadCM3, PCM and GFDL. Sensitivity results conducted on a single grid cell show that annual average surface runoff and baseflow were increased by 8 and 6 mm, respectively, while evapotranspiration was reduced by 15 mm when a fully forested grid was converted to cropland. Results also indicate that annual average net radiation and sensible heat flux were reduced considerably due to forest‐to‐cropland conversion, and the reduction was more prominent in winter and spring seasons due to effect of snow albedo. Forest‐to‐cropland conversion also resulted in increased latent heat flux in summer (JJA) while this land transformation increased the snow water equivalent in winter (DJF) and spring (MAM). Complete conversion of forest to cropland resulted in a decrease of the radiative surface temperature on an annual basis with more cooling occurring in winter and summer. Impacts of historic deforestation were similar to what was expected based on a single grid sensitivity analysis. Copyright © 2010 Royal Meteorological Society
A review of methods for estimating anthropogenic heat and moisture emissions in the urban environment
Authors: Sailor David J. 
Published: March 2010

AbstractEnergy consumption in the urban environment impacts the urban surface energy budget and leads to the emission of anthropogenic sensible heat and moisture into the atmosphere. Anthropogenic heat and moisture emissions vary significantly both in time and space, and are not readily measured. As a result, detailed models of these emissions are not commonly available for most cities. Furthermore, most attempts to quantify anthropogenic emissions have focused on the sensible heat component, largely ignoring moisture emissions and invoking assumptions—such as the equivalence of energy consumption and anthropogenic sensible heating—which limit the accuracy of the resulting anthropogenic heating estimates. This paper provides a historical perspective of the development of models of energy consumption in the urban environment and the associated anthropogenic impacts on the urban energy balance. It highlights some fundamental limitations of past approaches and suggests a roadmap forward for including anthropogenic heat and moisture in modelling of the urban environment. Copyright © 2010 Royal Meteorological Society
Assessing the retrieval of cloud properties from radiation measurements over snow and ice
Authors: Kuipers Munneke P. , Reijmer C. H. , van den Broeke M. R. 
Published: March 2010

AbstractWe critically review and improve a simple method to extract year‐round records of cloud optical thickness from radiation measurements made by automatic weather stations (AWSs) over snow and ice surfaces. A ‘longwave‐equivalent cloudiness’, Nε, obtained from longwave radiation measurements, is combined with the effective cloud optical thickness, τ, from shortwave data, to obtain consistent, year‐round information on cloud properties. The method is applied to radiation data from six AWSs in Dronning Maud Land, Antarctica, and the ablation area of the West‐Greenland ice sheet. The good correlation between daily‐mean Nε and τ for all locations (0.77 < r < 0.94) shows that shortwave radiative properties of clouds can be inferred using longwave radiation even in the absence of solar radiation itself. An error analysis shows that retrievals of τ are sensitive to the quality of the input data, but accurate to about 21% for hourly values, 11% for daily means, and about 6% for monthly means. As three applications of the method presented above, we discuss the influence of clouds on the radiation budget (Application I), the relation between cloud cover and broadband albedo (Application II) at the six AWS locations, and we demonstrate the possibility to detect trends in τ in longer data series (Application III). About one‐third of the attenuation of solar radiation by clouds is compensated by multiple reflections between the high‐albedo surface and the cloud base (Application I). Cloudy‐sky surface albedo is higher than the clear‐sky albedo for snow surfaces but not for ice (Application II): over snow surfaces, clouds deplete near‐infrared (IR) radiation and thus increase the broadband albedo. Ice surfaces have a much lower albedo for visible radiation, weakening this enrichment of visible radiation and thus the increase of broadband albedo. The method is used to detect a trend in τ of − 0.40 ± 0.15 y−1 in the 1995–2004 time series from Neumayer, Antarctica (Application III). Copyright © 2010 Royal Meteorological Society