bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dementia Education for Physiotherapy Students: A Questionnaire of Australian and Canadian Entry-To-Professional Practice Programs
Authors: Quick Stephen M. , Snowdon David A. , Lawler Katherine , Soh Sze-Ee , McGinley Jennifer L. , Hunter Susan W. , Callisaya Michele L. 
Published: June 2024

Purpose: To determine (1) what dementia education is provided to entry-to-professional practice physiotherapy students in Canada and Australia; (2) how this education is delivered; and (3) the challenges in delivering this education. Methods: A designated education provider from each university who offered entry-to-professional practice physiotherapy programs received a web-based questionnaire. Data were analyzed using descriptive statistics and qualitative content analysis. Results: Responses from 30/36 eligible universities resulted in 35 physiotherapy programs included for analysis. Canadian programs had a median of 5.5 hours (range, min-max, 0.5–13.0 hours), and Australia 4.0 hours (range, min-max, 2.0–22.0 hours) of dementia education. Lectures and tutorials were the most common method of delivery. There were varying amounts of education on topics such as cognition, communication, and behavioural symptoms and strategies. Challenges included dementia being difficult to teach, student stigma about people with dementia, difficulty providing students with real-life exposure to people with dementia, engaging students in the topic, and integrating dementia education into full programs. Conclusion: Dementia education across programs varies, with some programs lacking content on key topics such as cognitive, communication, and behavioural symptoms and strategies. These results may help physiotherapy accreditation organizations and universities develop dementia education standards and content.
Effectiveness of Continuous Dopaminergic Therapies in Parkinson’s Disease: A Review of L-DOPA Pharmacokinetics/Pharmacodynamics
Authors: Demailly Alexandre , Moreau Caroline , Devos David 
Published: June 2024

Background: Parkinson’s disease (PD) is characterized by striatal dopamine deficiency. Since dopamine cannot cross the digestive and blood-brain barriers, its precursor, levodopa (L-DOPA), remains the mainstay of treatment. However, the significant pharmacokinetic (Pk) and pharmacodynamic (Pd) limitations of L-DOPA, combined with the severity of PD, may trigger motor and non-motor complications, for which continuous dopaminergic delivery therapies have been developed. Objective: The aim of this study was to review the literature on the Pk/Pd limitations of L-DOPA and how current treatments of continuous dopaminergic administration ameliorate these problems, in order to identify the need for new therapeutic avenues. Methods: A comprehensive literature search was carried out using PubMed and 75 articles were initially extracted. Following independent screening by two reviewers and consideration of eligibility, 10 articles were chosen for further analysis. Information concerning the Pk/Pd of L-DOPA was classified for each article. Results: Pk/Pd problems notably include: (i) restricted digestive and cerebral absorption; (ii) unnecessary peripheral distribution; (iii) short half-life; (iv) age- and PD-induced decline of central aromatic L-amino acid decarboxylase; (v) misdistribution in many cells; and (vii) pulsatile stimulation of dopaminergic receptors. Current treatments only slightly ameliorate some of these problems. Conclusions: Many Pk/Pd constraints are not resolved by existing continuous dopaminergic delivery therapies. This highlights the significant gap between these treatments and the ideal of continuous dopaminergic stimulation.
Reflections on Retirement: The Sunset Can be Spooktacular!
Authors: Lapeña José Florencio 
Published: June 2024

Where are we headed, oh, where have we gone?
We’ve come a long way, now, let us move on.
Dreams are for dreaming, wake up and they run,
Life is for living, come, let us move on.1
1JF Lapena, Moving on

Retirement (n.); from French retirement (1570’s); retire + ment.
Retire (v.) 1530s, of armies, “to retreat, draw back,” also, of persons,
“to withdraw” to some place, especially for the sake of privacy; from
French retirer – from re- “back” + tirer “to draw” and -ment; common
suffix of Latin origin; came to be used as a formative in nouns of
action in Vulgar Latin and Old French. The sense of “leave one’s
business or occupation” is by 1660s.2

2Online Etymology Dictionary
https://www.etymonline.com/word/retirement
©2001-2024 Douglas Harper
Parental Influence on Smoking Behavior in Teenagers
Authors: Nurhalimah Nurhalimah , Putri Fauziah Yuliana , Haryati Omi , Banon Endang , Nurlaela Ela 
Published: June 2024

Adolescence is a problematic and difficult period because it often gives rise to several problems that are difficult to overcome, such as drug and cigarette dependence. The proportion of smoking among teenagers aged less than 15 years is greater than among those aged above because teenagers tend to have a greater curiosity, so they are more likely to smoke than adults. Parents are one of the factors causing smoking behavior in teenagers, because parents are figures for their children, so if parents smoke, teenagers tend to imitate their parents' behavior. Parents who smoke significantly increase teenagers' tendency to smoke by 1.397 times compared to teenagers whose parents are not smokers. Smoking has a huge negative impact on teenagers. Knowing how much influence parents have on adolescent smoking behavior. This research uses quantitative methods, and analytical descriptive design with a cross-sectional approach. The research population was teenagers with smoking behavior, totaling 83 respondents. The sampling technique uses purposive sampling. The questionnaire used was created by researchers from modifications from various sources. There is a significant relationship between parental influence and smoking behavior in adolescents. With an OR of 2,824, this means that parents have a 2,824 times chance of causing smoking behavior in teenagers. There is a need to educate parents not to smoke at home and in front of their children.
PENGARUH ONLINE CUSTOMER REVIEW DAN ENDORSEMENT INFULENCER TERHADAP MINAT BELI PRODUK SKINTIFIC PADA MEDIA SOSIAL TIKTOK
Authors: Pranita Khani 
Published: June 2024

Abstract: In the digital age, social media is used to interact to do business. One of the emerging social media is TikTok. With these social media, it creates influencers who create a variety of video content that works with a brand to promote a product or service. Endorse is a form of digital marketing advertising that involves other parties to support or promote a product or service so as to attract the interest of potential buyers. Online customer review is a tool that allows customers to freely and easily share their thoughts about products or services online. The purpose of this study is to find out the influence of Online Customer Review (X1), Endorsement Influencer (X2), and Buying Interest (Y). The survey population was consumers who were interested or purchased Skintific products due to Online Customer Review and Endorsement Influencer on TikTok Social Media. The sampling technique uses Purposive Sampling with the number of samples as many as 55. This data analysis technique uses PSPP software. The results of this research show that Online Customer Review and Endorsement Influencers have a positive and significant influence on Skintific Product Buy Interest on TikTok Social Media.
Abstrak: Pada era digital, media sosial digunakan untuk berinteraksi hingga berbisnis. Salah satunya media sosial yang sedang berkembang yaitu TikTok. Dengan adanya media sosial ini, menciptakan influencer yang membuat berbagai konten video yang bekerja sama dengan suatu merek guna mempromosikan produk atau jasa. Endorse adalah salah satu bentuk digital marketing periklanan yang melibatkan pihak lain untuk mendukung atau mempromosikan sebuah produk atau jasa sehingga menarik minat beli pembeli potensial. Online customer review adalah alat yang memungkinkan pelanggan secara bebas dan mudah membagikan pemikiran mereka tentang produk atau jasa secara online. Tujuan penelitian ini adalah untuk mengetahui pengaruh Online Customer Review (X1), Endorsement Influencer (X2), dan Minat Beli (Y). Populasi penelitian ini adalah konsumen yang pernah berminat atau membeli produk Skintific dikarenakan Online Customer Review dan Endorsement Influencer pada Media Sosial TikTok. Teknik pengambilan sampel menggunakan Purposive Sampling dengan jumlah sampel sebanyak 55. Teknik analisis data penelitian ini menggunakan software PSPP. Hasil penelitian ini menunjukan bahwa Online Customer Review dan Endorsement Influencer berpengaruh secara positif dan signifikan terhadap Minat Beli produk Skintific pada Media Sosial TikTok.
PENGARUH PEMBERIAN TIMBAL (Pb) TERHADAP PERTUMBUHAN DUA VARIETAS LADA (Piper nigrum L)
Authors: Santi Ratna , Pratama Deni , TV Nababan 
Published: June 2024

The pepper (Piper nigrum L.) a plantation crop that widely cultivated farmers in Indonesia, especially in Bangka Belitung Islands. One of the challenges of pepper cultivation in Bangka Belitung is the reduction in land conversion caused by tin mining. Tin mining causes high levels heavy metal content. The heavy metal lead (Pb) is element that can influence its growth. Pb are will become an inhibitor of enzyme formation which inhibits plant metabolism and effect growh of pepper. The aim of this research to determine the effect of giving Pb to both varieties and determine which varieties are adaptive in planting media containing Pb. This research was carried out April to July, at Bangka Belitung University. The method used was experiment and the design used was a randomized (RAKF). Treatment consists 2 factors. The first factor is Petaling 1 cultivar and the Nyelungkup cultivar. The second factor, Pb concentration which consists of Pb concentration of 0 ppm, 100 ppm and 200 ppm. Data analysis used the F test (ANOVA) followed the Duncan’s Multiple Range Test (DMRT). The research results showed each cultivar did not have a real influence on the observed parameters. Aplication Pb concentrations 100 and 200 Ppm had effect on plant height, number of leaves, increasing number of shoots, leaf area and root length and root fresh weight. Nyelungkup cultivar is a cultivar that is better able to adapt to growing media contaminated with the heavy metal Pb better than Petaling 1.
Programa Stewardship de antimicrobianos em Unidade de Terapia Intensiva adulto: Uma revisão integrativa
Authors: Oliveira Luana Cristina Maia de , Eller Lizzianne Kretli Winkelstroter , Souza Adriano Messias de 
Published: June 2024

Pacientes internados em UTI estão mais propensos a adquirir infecções relacionadas à saúde devido ao seu quadro clínico grave e o uso inadequado dos antimicrobianos que pode acarretar no aumento de resistência bacteriana. Neste contexto, uma estratégia para o controle da resistência bacteriana é o Antimicrobial Stewardship definido como intervenções coordenadas para diminuir o uso inadequado dos antimicrobianos, reduzir o desenvolvimento de resistência e reduzir custos. Objetivo: Realizar uma revisão integrativa sobre a aplicação do Stewardship de antimicrobianos em desfechos clínicos e econômicos de pacientes adultos internados em UTI. Metodologia: Esta revisão adotou a estratégia PICo para elaboração da pergunta “Quais melhorias que o programa Stewardship de antimicrobianos podem trazer para unidades de terapia intensiva adulto?”. Foram utilizadas as bases de dados: LILACS, PubMed Central, SCOPUS, EMBASE, WEB OF SCIENCE, SCIENCE DIRECT e MEDLINE, com artigos publicados em inglês entre os anos de 2018 a 2023. Os descritores DeCS e MeSH foram: “Intensive Care Units”, “Antimicrobial Stewardship”, “Drug Resistance, Bacterial”, “Infection Control”. Resultados: Doze estudos estavam em concordância com os critérios de inclusão estabelecidos e demonstraram que a adesão às intervenções propostas pelo Programa Stewardship de Antimicrobianos estão associadas a uma diminuição do tempo e doses de terapia antibiótica, além de estimular o uso racional em UTI. Conclusão: O Programa Stewardship de Antimicrobianos em UTI adulto traz benefícios na diminuição na resistência bacteriana e no uso de antimicrobianos. Consequentemente reduzindo custos hospitalares, sendo o farmacêutico a peça chave na estratégia no uso racional e seguro dos antimicrobianos.
A comprehensive approach for osteoporosis detection through chest CT analysis and bone turnover markers: harnessing radiomics and deep learning techniques
Authors: Fang Kaibin , Zheng Xiaoling , Lin Xiaocong , Dai Zhangsheng 
Published: June 2024

PurposeThe main objective of this study is to assess the possibility of using radiomics, deep learning, and transfer learning methods for the analysis of chest CT scans. An additional aim is to combine these techniques with bone turnover markers to identify and screen for osteoporosis in patients.MethodA total of 488 patients who had undergone chest CT and bone turnover marker testing, and had known bone mineral density, were included in this study. ITK-SNAP software was used to delineate regions of interest, while radiomics features were extracted using Python. Multiple 2D and 3D deep learning models were trained to identify these regions of interest. The effectiveness of these techniques in screening for osteoporosis in patients was compared.ResultClinical models based on gender, age, and β-cross achieved an accuracy of 0.698 and an AUC of 0.665. Radiomics models, which utilized 14 selected radiomics features, achieved a maximum accuracy of 0.750 and an AUC of 0.739. The test group yielded promising results: the 2D Deep Learning model achieved an accuracy of 0.812 and an AUC of 0.855, while the 3D Deep Learning model performed even better with an accuracy of 0.854 and an AUC of 0.906. Similarly, the 2D Transfer Learning model achieved an accuracy of 0.854 and an AUC of 0.880, whereas the 3D Transfer Learning model exhibited an accuracy of 0.740 and an AUC of 0.737. Overall, the application of 3D deep learning and 2D transfer learning techniques on chest CT scans showed excellent screening performance in the context of osteoporosis.ConclusionBone turnover markers may not be necessary for osteoporosis screening, as 3D deep learning and 2D transfer learning techniques utilizing chest CT scans proved to be equally effective alternatives.
Prognostic factors of patients with thyroid cancer and bone metastasis at presentation
Authors: Yao Zhaonong , Yao Yuhong , Zhou Xiaowei , Shen Shujia , Hu Xiaofeng , Gao Qian 
Published: June 2024

ObjectiveWhile bone metastases (BMs) are present in a minority of thyroid cancer (TC) patients at the time of initial diagnosis, there has been growing concern regarding their impact on life expectancy and quality of life. The aim of this study was to identify prognostic factors associated with overall survival (OS) and cancer-specific survival (CSS) in these patients and provide therapeutic recommendations based on the findings.MethodsIn this retrospective cohort study, we included 82 patients diagnosed as TC with BM received treatment in our department from 2011.03 to 2023.03 (average follow-up duration was 3.02 years). The retrospective study was performed according to the inclusion and exclusion criteria. Kaplan-Meier analysis was used to estimate the OS and CSS, while the univariate and multivariate Cox proportional hazard models were employed to determine prognostic factors associated with OS and CSS. Also, 287 patients’ data were collected from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2015 to confirm the prognostic factors identified in the retrospective study.ResultsThe average survival time of the 82 patients was estimated to be 5.818 years (with a 95% confidence interval (CI) of 4.767 to 6.868 years). The cox regression analysis showed that older age (hazard ratio (HR) = 1.045, 95% CI: 1.001-1.092, P = 0.047), larger tumor size (&gt;5cm, HR = 11.087, 95% CI: 3.728 - 32.976, P = 0.000), and the presence of extraosseous metastasis (HR = 3.247, 95% CI: 1.376 - 7.665, P = 0.007) were statistically significant factors associated with worse CSS. The results were furtherly confirmed in 287 SEER-sourced patients (age (HR = 1.020, 95% CI: 1.006 - 1.034, P = 0.006), tumor size (HR = 2.917, 95% CI: 2.044 - 4.161, P = 0.000), and extraosseous metastasis (HR = 3.726, 95% CI: 2.571 - 5.398, P = 0.000)).ConclusionsThese results offer a population-based assessment of prognostic factors for patients with TC and BMs, revealing that age, primary tumor size (&gt;5cm), and presence of extraosseous metastases are independent prognostic factors that correlate with worse survival. Accordingly, treatment for such patients ought to concentrate on systemic integrative therapy instead of surgical intervention.
Association between monocyte to high-density lipoprotein cholesterol ratio and kidney stone: insights from NHANES
Authors: Wang Zhaoxiang , Zhao Guang , Cao Yuanfei , Gu Tian , Yang Qichao 
Published: June 2024

PurposeThe ratio of monocyte to high-density lipoprotein cholesterol (MHR) has surfaced as a novel biomarker indicative of inflammation and oxidative stress. The aim of our study was to evaluate the association between MHR and the risk of kidney stones.MethodsThis study analyzed data from individuals aged 20-79 who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018. The MHR was assessed as the exposure variable, while a self-reported history of kidney stones was used as the outcome variable. The independent relationship between MHR and the risk of kidney stones was thoroughly evaluated.ResultsThis study included 28,878 participants, and as the quartile range of the MHR increased, the proportion of kidney stones also rose progressively (7.20% to 8.89% to 10.88% to 12.05%, P&lt;0.001). After adjusting for confounding factors, MHR was independently associated with an increased risk of kidney stones (OR=1.31, 95%CI=1.11-1.54, P=0.001), also independent of some common inflammatory indices. Subgroup analysis suggested that the relationship between MHR and kidney stones was more pronounced in female and individuals aged 20-49. Further restricted cubic spline (RCS) analysis indicated a nonlinear relationship between MHR and the risk of kidney stones.ConclusionOur results indicate a positive correlation between MHR and an increased risk of kidney stones in US adults, underscoring the need for further large-scale prospective cohort studies to validate these findings.
IL-1 and TNF mediates IL-6 signaling at the maternal-fetal interface during intrauterine inflammation
Authors: Presicce Pietro , Roland Cynthia , Senthamaraikannan Paranthaman , Cappelletti Monica , Hammons McKensie , Miller Lisa A. , Jobe Alan H. , Chougnet Claire A. , DeFranco Emily , Kallapur Suhas G. 
Published: June 2024

IntroductionIL6 signaling plays an important role in triggering labor and IL6 is an established biomarker of intrauterine infection/inflammation (IUI) driven preterm labor (PTL). The biology of IL6 during IUI at the maternal-fetal interface was investigated in samples from human subjects and non-human primates (NHP).MethodsPregnant women with histologic chorioamnionitis diagnosed by placenta histology were recruited (n=28 term, n=43 for preterm pregnancies from 26-36 completed weeks of gestation). IUI was induced in Rhesus macaque by intraamniotic injection of lipopolysachharide (LPS, n=23). IL1 signaling was blocked using Anakinra (human IL-1 receptor antagonist, n=13), and Tumor necrosis factor (TNF) signaling was blocked by anti TNF-antibody (Adalimumab n=14). The blockers were given before LPS. All animals including controls (intraamniotic injection of saline n=27), were delivered 16h after LPS/saline exposure at about 80% gestation.ResultsIUI induced a robust expression of IL6 mRNAs in the fetal membranes (chorion-amnion-decidua tissue) both in humans (term and preterm) and NHP. The major sources of IL6 mRNA expression were the amnion mesenchymal cells (AMC) and decidua stroma cells. Additionally, during IUI in the NHP, ADAM17 (a protease that cleaves membrane bound IL6 receptor (IL6R) to release a soluble form) and IL6R mRNA increased in the fetal membranes, and the ratio of IL6 and soluble forms of IL6R, gp130 increased in the amniotic fluid signifying upregulation of IL6 trans-signaling. Both IL1 and TNF blockade suppressed LPS-induced IL6 mRNAs in the AMC and variably decreased elements of IL6 trans-signaling.DiscussionThese data suggest that IL1 and TNF blockers may be useful anti-inflammatory agents via suppression of IL6 signaling at the maternal-fetal interface.
Causal effects of gut microbiota on chalazion: a two-sample Mendelian randomization study
Authors: Zhang Wenfei , Gu Xingwang , Zhao Qing , Wang Chuting , Liu Xinyu , Chen Youxin , Zhao Xinyu 
Published: June 2024

PurposeTo investigate the causal relationship between gut microbiota (GM) and chalazion through Mendelian randomization (MR) analysis.MethodsGM-related genome-wide association studies (GWAS) were obtained from the International Consortium MiBioGen. Genetic data for chalazion were sourced from the MRC Integrative Epidemiology Unit (IEU) Open GWAS database. Five MR methods, including inverse variance weighted (IVW), were employed to estimate causal relationships. Cochran’s Q test was used to detect heterogeneity, the MR-Egger intercept test and MR-PRESSO regression were utilized to detect horizontal pleiotropy, and the leave-one-out method was employed to validate data stability.ResultsWe identified 1,509 single nucleotide polymorphisms (SNPs) across 119 genera as instrumental variables (IVs) (p &lt; 1 × 10−5). According to the inverse variance weighted (IVW) estimate, the Family XIII AD3011 group (OR = 1.0018, 95% CI 1.0002–1.0035, p = 0.030) and Catenibacterium (OR = 1.0013, 95% CI 1.0002–1.0025, p = 0.022) were potentially associated with increased risk of chalazion. Conversely, Veillonella (OR = 0.9986, 95% CI 0.9974–0.9999, p = 0.036) appeared to provide protection against chalazion. There was no evidence of heterogeneity or pleiotropy.ConclusionThis study uncovered the causal relationship between GM and chalazion, pinpointing Catenibacterium and Family XIII AD3011 group as potential risk contributors, while highlighting Veillonella as a protective factor. In-depth investigation into the potential mechanisms of specific bacteria in chalazion was essential for providing novel therapeutic and preventive strategies in the future.