bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long Non-coding RNA DANCR Regulates the Proliferation and Migration of Human Adipose-derived Mesenchymal Stromal Cells in Inflammation
Conditions
Authors: Yan Ran , Dong Ping , Yang Zhigang , Cao Rui , Xiao Ran , Liu Xia 
Published: June 2024

Background:
Mesenchymal stromal cells (MSCs) and Dexamethasone (Dex) are both
effective methods to treat inflammatory diseases. However, the interaction between inflammatory
factors, Dex, and MSCs in repair is not fully understood. The purpose of this study is to clarify
the effects and mechanisms of glucocorticoids on the tissue repair characteristics of MSCs in an
inflammatory environment.

Methods:
This is an experimental study. Human adipose-derived mesenchymal stromal cells
(hASCs) were cultured, and Long non-coding RNA (lncRNA) differentiation antagonizing nonprotein
coding RNA (DANCR) expression was detected after treatment with Dex and inflammation
factors. Additionally, DANCR was knockdown or overexpressed before Dex or tumor necrosis
factor-alpha (TNF-α) treatments, respectively. hASC proliferation, cell cycle, and migration
ability were analyzed to evaluate the effects of DANCR in hASCs treated with Dex or TNF-α. Nuclear
factor-kB (NF-κB) pathway inhibitors were used to clarify the signal pathway that DANCR
involved. All data are presented as the mean ± standard deviation. The two-tailed Student's t-test
or one-way analysis of variance (ANOVA) was used to determine the statistical differences between
groups.

Results:
Dex decreased the proliferation and migration of hASCs and upregulated DANCR expression
in a dosage-dependent relationship. The knockdown of DANCR reversed Dex's repression
of hASC proliferation. Moreover, DANCR was decreased by inflammatory cytokines, and
overexpressing DANCR alleviated the promotion effects of TNF-α on hASC proliferation and migration.
Furthermore, mechanistic investigation validated that DANCR was involved in the NF-
κB signaling pathway.

Conclusions:
We identified a lncRNA, DANCR, that was involved in Dex and inflammation-affected
hASC proliferation and migration. Dex reduced the proliferation and migration of hASCs
through DANCR while exerting its anti-inflammatory effects. Thus, it is suggested to avoid the simultaneous
application of hASCs and steroids in clinical practice. These results enrich our understanding
of the versatile function of lncRNAs in the crosstalk of inflammation conditions and
MSCs.
Exploring Biomedical Named Entity Recognition via SciSpaCy and BioBERT Models
Authors: Jolly Aman , Pandey Vikas , Singh Indrasen , Sharma Neha 
Published: June 2024

IntroductionBiological Named Entity Recognition (BioNER) is a crucial preprocessing step for Bio-AI analysis.MethodsOur paper explores the field of Biomedical Named Entity Recognition (BioNER) by closely analysing two advanced models, SciSpaCy and BioBERT. We have made two distinct contributions: Initially, we thoroughly train these models using a wide range of biological datasets, allowing for a methodical assessment of their performance in many areas. We offer detailed evaluations using important parameters like F1 scores and processing speed to provide precise insights into the effectiveness of BioNER activities.ResultsFurthermore, our study provides significant recommendations for choosing tools that are customised to meet unique BioNER needs, thereby enhancing the efficiency of Named Entity Recognition in the field of biomedical research. Our work focuses on tackling the complex challenges involved in BioNER and enhancing our understanding of model performance.ConclusionThe goal of this research is to drive progress in this important field and enable more effective use of advanced data analysis tools for extracting valuable insights from biomedical literature.
HIV Incidence and Transactional Sex Among Men Who Have Sex With Men in Ningbo, China: Prospective Cohort Study Using a WeChat-Based Platform
Authors: Hong Hang , Shi Xiaojun , Liu Yuhui , Feng Wei , Fang Ting , Tang Chunlan , Xu Guozhang 
Published: June 2024

Abstract

Background
Sexual transmission among men who have sex with men (MSM) has become the major HIV transmission route. However, limited research has been conducted to investigate the association between transactional sex (TS) and HIV incidence in China.

Objective
This study aims to investigate HIV incidence and distinguish sociodemographic and sexual behavioral risk factors associated with HIV incidence among MSM who engage in TS (MSM-TS) in China.

Methods
We conducted a prospective cohort study using a WeChat-based platform to evaluate HIV incidence among Chinese MSM, including MSM-TS in Ningbo, recruited from July 2019 until June 2022. At each visit, participants completed a questionnaire and scheduled an appointment for HIV counseling and testing on the WeChat-based platform before undergoing offline HIV tests. HIV incidence density was calculated as the number of HIV seroconversions divided by person-years (PYs) of follow-up, and univariate and multivariate Cox proportional hazards regression was conducted to identify factors associated with HIV incidence.

Results
A total of 932 participants contributed 630.9 PYs of follow-up, and 25 HIV seroconversions were observed during the study period, resulting in an estimated HIV incidence of 4.0 (95% CI 2.7-5.8) per 100 PYs. The HIV incidence among MSM-TS was 18.4 (95% CI 8.7-34.7) per 100 PYs, which was significantly higher than the incidence of 3.2 (95% CI 2.1-5.0) per 100 PYs among MSM who do not engage in TS. After adjusting for sociodemographic characteristics, factors associated with HIV acquisition were MSM-TS (adjusted hazard ratio [aHR] 3.93, 95% CI 1.29-11.93), having unprotected sex with men (aHR 10.35, 95% CI 2.25-47.69), and having multiple male sex partners (aHR 3.43, 95% CI 1.22-9.64) in the past 6 months.

Conclusions
This study found a high incidence of HIV among MSM-TS in Ningbo, China. The risk factors associated with HIV incidence include TS, having unprotected sex with men, and having multiple male sex partners. These findings emphasize the need for developing targeted interventions and providing comprehensive medical care, HIV testing, and preexposure prophylaxis for MSM, particularly those who engage in TS.
Association Between Microvascular Disease and Cardiorespiratory Fitness Among Adults With Type 2 Diabetes
Authors: Kaze Arnaud D. , Santhanam Prasanna , Ahima Rexford S. , Bertoni Alain G. , Echouffo-Tcheugui Justin B. 
Published: June 2024

OBJECTIVE
Little is known about the extent to which microvascular disease is associated with cardiorespiratory fitness (CRF) among individuals with type 2 diabetes.

RESEARCH DESIGN AND METHODS
A total of 4,766 participants with type 2 diabetes underwent maximal exercise testing in the Look AHEAD (Action for Health in Diabetes) study at baseline. Low CRF was defined based on the Aerobics Center Longitudinal Study reference standards. Microvascular disease was defined as having one or more of diabetes-related kidney disease (DKD), retinopathy, and neuropathy. The burden of microvascular disease was defined as the number of microvascular beds affected.

RESULTS
Of the 4,766 participants (mean age 58.9 ± 6.7 years, 58.5% women, 66.1% White individuals), 1,761 (37%) had microvascular disease. Participants with microvascular complications in three vascular territories had a lower CFR than those without any microvascular disease (mean adjusted metabolic equivalent of task [MET] 6.58 vs. 7.26, P = 0.001). Participants with any microvascular disease had higher odds of low CRF than those without microvascular disease (adjusted odds ratio [OR] 1.45, 95% CI 1.24–1.71). An increasing burden of microvascular disease was associated with higher odds of low CRF (for microvascular disease in three vascular territories, adjusted OR 2.82, 95% CI 1.36–5.85). Adjusted ORs for low CRF were 1.24 (95% CI 0.99–1.55), 1.34 (95% CI 1.02–1.76), and 1.44 (95% CI 1.20–1.73) for neuropathy, retinopathy, and DKD associations, respectively.

CONCLUSIONS
In a large cohort of adults with type 2 diabetes, the presence of microvascular disease and its burden were independently associated with lower CRF.
Growth Allometry of Sweet Corn as Influenced by Tillage and Seaweed under Tarai Region of Nagaland
Authors: Kumari Shivani , Tzudir Lanunola , Merentoshi  , Chishi Hillel M. , Yosung Lenmem , Malemnganbi Takhelmayum , Zion G. , Debbarma John , Jamir Zulutemjen , Lytan Damitre , Marwein B. Selectstar , Roy Shalini 
Published: June 2024

A study was carried out at Crop Research Farm, Department of Agronomy, SAS, Nagaland University, Nagaland, India during kharif (May-September, 2021 and 2022) situated at 25° 45’ 3.68”N latitude and 93° 51’ 29.79” E longitude, to study the influence of tillage and seaweed extract on growth allometry of sweet corn under tarai region of Nagaland. The experiment was conducted in split plot design with two factor treatment and was replicated thrice. Factor one comprised of three tillage practices viz., conventional tillage, minimum tillage and zero tillage in the main plots and factor two included seven treatments consisting of seed priming followed by foliar spray of seaweeds i.e. Kappaphycus alvarezii and Sargassum wightii viz., water spray (control), K-Seaweed sap 5%, K-Seaweed sap 10%, K-Seaweed sap 15%, S-Seaweed sap 5%, S-Seaweed sap 10%, S-Seaweed sap 15%, in the sub-plots at 30, 50 and 70 days after sowing. Results of study revealed that significantly higher stem girth, leaf area, leaf area index, leaf area duration, SPAD meter reading at different intervals were noticed in conventional tillage. When seeds were treated with 10% S-Sap along with 10% S-Sap spray at three different intervals recorded significantly higher stem girth, number of functional leaves plant-1, leaf area, leaf area index, leaf area duration and chlorophyll index readings.
Studi Pengaruh Volume Tungsten terhadap Optimalisasi Biaya Proses Carbon Analyzer di PT.XYZ
Authors: Setiawan Dibyo , Handy Rayhan Aliva Vitra , Wibowo Cahyo , Wiyono Apri , Putra Fisika Prasetyo , Rinaldi Kardian 
Published: June 2024

PT XYZ merupakan suatu perusahaan joint venture, terdapat 2 (dua) macam proses produksi, yaitu Proses Casting dan Proses Machining, dalam proses produksi Casting, tersedia produk FC (Ferro Casting), FCD (Ferro Casting Ductile) dan dapat juga melaksanakan proses Machining, Assembling serta Metal Forming. Penghargaan yang telah diperoleh Cost Reduction Program, Good Delivery Perfomance, Good Cost Perfomance, dan Kategori Proses. Salah satu fokus terkait Cost Reduction Program bertujuan optimalisasi konsumsi dan biaya penggunaan tungsten, serta biaya tenaga kerja. Kegiatan merupakan kontribusi akademisi memberikan rekomendasi bagi PT.XYZ dalam rangka menyelesaikan masalah di Industri. Metode yang digunakan dalam pelaksanaan kegiatan optimalisasi proses carbon analyzer di PT.XYZ menggunakan pendekatan eksperimental dengan pemberlakuan volume tungsten pada setiap tahap eksperimen. Tahapan meliputi penyiapan alat, peralatan dan sampel, proses penimbangan dan pencampuran, proses treatment carbon analyzer, analisis hasil eksperimen dan kalkulasi reduksi biaya dan menyusun kesimpulan. Eksperimen yang diterapkan diantaranya volume 0, 0.75, 1.5 dan 1.8 Gram pada Treatmen Carbon Analyzer. Hasil kegiatan diperoleh bahwa semakin banyak penggunaan volume tungsten pada proses carbon analyzer, dapat mengurangi waktu pengerjaan yang dibutuhkan oleh mesin carbon analyzer sebanyak 3 (tiga) detik. Penggunaan tungsten 0,75gram (½ dari standard) lebih efektif mampu menghemat biaya penggunaan tungsten (Cost Reduction). Selanjutnya terkait dengan penghematan, dengan menggunakan penerapan tungsten 0,75gram dapat menghemat biaya sebesar Rp 14.149.779/bulan dan penghematan biaya tenaga kerja sebesar 250.000/bulan.
Molecular tools for epidemiological investigations into Legionella pneumophila environmental diffusion: applications for the prevention
Authors: Boccia Stefania , Spica Vincenzo Romano , Ricciardi Walter 
Published: June 2024

Microbiological typing is a useful tool in the epidemiological investigations of infectious diseases, given that it allows for the identification of specific clones among a set of isolates.
In the last ten years several studies have demonstrated how genotyping methods can be useful in Legionella spp investigations in hospital setting (e.g., epidemic events). Pulsed field gel electrophoresis and amplified fragment length polymorphisms are the current typing methods of choice, even though multilocus sequence typing will probably be the gold standard of the future.
Legionnaires’ disease and occupational risk: a case report
Authors: Mansi Antonella , Paba Emilia , Marcelloni Anna Maria , Bruni Roberta , Spagnoli Giuseppe 
Published: June 2024

We report results of environmental microbiological sampling in an office building whose occupants referred different symptoms ascribable to the air conditioning system.
Legionella pneumophila serogroup 1 was detected in water samples drawn from the cooling tower with counts that ranged from 1.4 x105 to 1.5x107 CFU/L.
This biological agent is classified in the second risk group according to Italian law (D.Lgs. 626/94), consequently proper control measures in order to re-establish acceptable hygienic environment conditions and to assure healthy workplace are needed.
Evaluation of benzene exposure in petrol pump attendants and in mechanics by urinary trans, trans-muconic acid (t, t-MA) determination
Authors: Cirillo Teresa , Arnese Antonio , Spagnoli Giuseppe , Amodio Cocchieri Renata , Del Prete Umberto 
Published: June 2024

Occupational exposure to benzene in petrol pump attendants and in mechanics was studied by examining the benzene content in both the air breathed and in the urinary metabolite trans,trans-muconic acid (t,t-MA). Thirty petrol pump attendants and thirty mechanics (as exposed workers) and thirty adult male office workers (as non exposed workers) were involved in the study. Measures were taken at the begin and at the end of the working shifts.
The benzene concentrations in the breathing air samples varied from 2 to 88 μg m-3, lower than the EU acceptable limit for occupational environment. The average urinary t,t-MA in the petrol pump attendants at the begin and at the end of the working shifts ranged between 133 ± 69 and 255 ± 174 μg g-1 creatinine and in the mechanics between 204 ± 139 and 300 ± 211 μg g-1 creatinine, respectively.
In all the participants the mean levels of urinary t,t-MA at the end of the working shifts were significantly higher than those at the beginning. In the exposed workers mean levels of urinary t,t-MA were significantly higher than in those of the non-exposed workers. The influence of the smoking was demonstrated by the urinary t,t-MA levels in smoking non-exposed subjects.
Genetic parameters and correlations in growth and wood density traits of Balfourodendron riedelianum based on provenance and progeny testing
Authors: Longui Eduardo L. , de Lima Israel L. , Paneque Letícia , Machado José A. R. , Freitas Miguel L.M. , Sebbenn Alexandre M. 
Published: June 2024

Abstract

Balfourodendron riedelianum is an important timber species of South America used in civil construction and carpentry. Knowing the genetic variation, heritability and correlation between traits is an essential prerequisite for guiding selection of the best genotypes in tree improvement. In this study, growth (diameter and height) and wood density (mean, pith, middle and bark position) traits were investigated in 30-year-old trees planted in a B. riedelianum provenance and progeny test established in two sites, Luiz Antônio (LA) and Pederneiras (PE), in São Paulo State (Brazil). ANOVA results showed significant differences between sites for all traits, among provenances and families for wood density traits in the LA site and among families for growth traits in PE. Provenance x site and family x site interactions were significant for almost traits, and genetic correlation between sites was low for all traits (0.17–0.20). Genetic variation (CV
g) was higher (4.0–5.4 %) and mean family heritability (h
m
2) was lower for growth (0.12–0.20) compared to wood density (CV
g: 2.3–3.8%, h
m
2: 0.31–0.59) traits. Genetic correlation was significantly positive and ranged from moderate to high between growth traits (0.47–0.68) and between wood density traits (0.42–0.83) and non-significant between growth and wood density (-0.22–0.30) traits. An analysis of different radial positions showed that heritability tended to increase from pith to the bark position. Our results show a lower environmental effect on wood density traits, allowing the possibility of selecting superior provenances and families with high wood quality in breeding programs in both sites.
Reduksi Parameter pada Soft Set
Authors: Zukri Mhd , Nazra Admi , Yanita Yanita 
Published: June 2024

Soft set merupakan salah satu teori matematika yang mengkaji tentang ketidakpastian dalam suatu pengambilan keputusan dalam kehidupan sehari-hari. Di sisi lain, sering kali terjadi pengambilan keputusan dengan melibatkan data yang banyak. Terdapat kemungkinan beberapa data tersebut ada yang dapat diabaikan tanpaÂ mengubah keputusan awalnya. Usaha untuk mengabaikan beberapa informasi yang berlebihan tanpa mengubah hasil keputusan awalnya disebut dengan reduksi parameter.Â Pada penelitian ini, dikaji kembali konsep reduksi parameter oleh Kong, dkk tahun 2008Â yang menggunakan suatu metode dimana derajat kepentingan digunakan sebagai acuanÂ untuk mereduksi parameter dalam pengambilan keputusan. Selanjutnya metode ini akanÂ dibandingkan dengan algoritma alternatif yang mana proses reduksinya cukup denganÂ menghitung kelipatan dari banyaknya objek dalam pengambilan keputusan.
Vision-Based Marker-Less Landing of an Unmanned Aerial System on Moving Ground Vehicle
Authors: Krpec Blake , Valasek John , Nogar Stephen 
Published: June 2024

Current autonomous unmanned aerial systems (UASs) commonly use vision-based landing solutions that depend upon fiducial markers to localize a static or mobile landing target relative to the UAS. This paper develops and demonstrates an alternative method to fiducial markers with a combination of neural-network-based object detection and camera intrinsic properties to localize an unmanned ground vehicle (UGV) and enable autonomous landing. Implementing this visual approach is challenging given the limited compute power on board the UAS, but it is relevant for autonomous landings on targets for which affixing a fiducial marker a priori is not possible or not practical. The position estimate of the UGV is used to formulate a landing trajectory that is then input to the flight controller. Algorithms are tailored toward low size, weight, and power constraints, as all compute and sensing components weigh less than 100 g. Landings were successfully demonstrated in both simulation and experimentally on a UGV traveling in both a straight line and while turning. Simulation landings were successful at UGV speeds of up to 3.0 m/s, and experimental landings at speeds up to 1.0 m/s.
Неполные семьи в Туве и Казахстане: статистико-демографический взгляд на проблему
Authors: Ростовская Тамара Керимовна , Натсак Органа Доржуевна , Еламанова Айнур Султановна 
Published: June 2024

В статье представлен сравнительный анализ статистико-демографического измерения неполных семей в Туве (Россия) и Казахстане на современном этапе. Рассматриваются ключевые факторы, влияющие на причины распространения семей с неполной структурой. В качестве источников были использованы итоги Всероссийских переписей населения 2010 и 2020 гг., Национальной переписи населения Республики Казахстан 2009, 2021 гг.; материалы текущей демографической статистики, касающиеся гендерных характеристик населения Тувы и Казахстана, рождаемости, в том числе, вне брака, ожидаемой продолжительности жизни, брачной структуры рассматриваемых обществ, коэффициентов разводимости, а также экономического положения и доходной стратификации семей разных типов.
В результате социодемографических трансформаций и в Туве, и Казахстане наблюдается рост монородительских семей, однако удельный вес нуклеарных неполных семей в Казахстане выше, чем в Туве. Количественная гендерная дифференциация в структуре современного населения более выражена в Туве, чем в Казахстане, что в свою очередь влияет на брачную структуру населения. В казахском обществе уровень брачности выше по сравнению с тувинским. В Туве доля незарегистрированных супружеских союзов более чем в два раза выше, чем в Казахстане, что отрицательно влияет на качество семейной структуры населения.
Показано, что структура причин формирования и типология неполных семей в Туве и Казахстане имеют существенные различия. Для казахстанского общества более свойственно общественное порицание и осуждение внебрачной рождаемости и одинокого материнства.
Для обоих обществ характерен высокий уровень рождаемости, однако имеются заметные различия в уровне внебрачной рождаемости и подростковой фертильности, которые являются причиной формирования неполных семей. В Туве они — выше.
Распад семьи в результате развода практически в равной степени характерен для обоих регионов. Неполные семьи потенциально подвержены риску бедности, особенно детской бедности, и социальной неустойчивости, эти риски высоки для тех монородителей, кто воспитывает более одного ребенка, детей с инвалидностью, имеет невысокий уровень образования.
Correlation of Global Longitudinal Strain with Functional Status of Patients with Left Ventricular Systolic Dysfunction: Does Gender Difference Exist?
Authors: Beura Biraja Prasad , Singh Subhasish 
Published: June 2024

Objectives:
Two-dimensional (2D) echocardiographic (echo) assessment of the left ventricular ejection fraction (LVEF) by Simpson’s biplane method is routinely used in clinical practice for patient management. The measurement of global longitudinal strain (GLS) using speckle tracking echocardiography is a new method for assessing left ventricular (LV) systolic function with several advantages. There are very few observations regarding the correlation of 2D GLS with the functional status of patients with the LV systolic dysfunction (LVSD). Therefore, we aimed to evaluate the superiority of GLS over Simpson’s method of LVEF in predicting the functional status of the patients with moderate-to-severe LVSD (ejection fraction <40%) and to find out if any difference exists between male and female patients.

Materials and Methods:
Fifty patients aged 18–80 years satisfying the inclusion and exclusion criteria were studied over a period of 2 months. Simpson’s method was used to calculate 2D LVEF. 2D GLS was assessed using an automated function imaging technique. The Minnesota living with heart failure questionnaire was used to assess the functional status of patients.

Results:
Correlation of functional status of patients was better with 2D GLS than 2D LVEF, although both were found to be statistically significant and no statistically significant difference was found in observations between both genders.

Conclusion:
The correlation of functional status of patients with moderate-to-severe LVSD was better with 2D GLS than 2D LVEF. Further studies are needed to identify the gender differences in 2D GLS correlation with the functional status of patients with LVSD.