bluuebunny/crossref_metadata_2025_split huggingface dataset:
Learning Sea Surface Height Interpolation From Multi‐Variate Simulated Satellite Observations
Authors: Archambault Théo , Filoche Arthur , Charantonis Anastase , Béréziat Dominique , Thiria Sylvie 
Published: June 2024

AbstractSatellite‐based remote sensing missions have revolutionized our understanding of the Ocean state and dynamics. Among them, space‐borne altimetry provides valuable Sea Surface Height (SSH) measurements, used to estimate surface geostrophic currents. Due to the sensor technology employed, important gaps occur in SSH observations. Complete SSH maps are produced using linear Optimal Interpolations (OI) such as the widely used Data Unification and Altimeter Combination System (duacs). On the other hand, Sea Surface Temperature (SST) products have much higher data coverage and SST is physically linked to geostrophic currents through advection. We propose a new multi‐variate Observing System Simulation Experiment (OSSE) emulating 20 years of SSH and SST satellite observations. We train an Attention‐Based Encoder‐Decoder deep learning network (abed) on this data, comparing two settings: one with access to ground truth during training and one without. On our OSSE, we compare abed reconstructions when trained using either supervised or unsupervised loss functions, with or without SST information. We evaluate the SSH interpolations in terms of eddy detection. We also introduce a new way to transfer the learning from simulation to observations: supervised pre‐training on our OSSE followed by unsupervised fine‐tuning on satellite data. Based on real SSH observations from the Ocean Data Challenge 2021, we find that this learning strategy, combined with the use of SST, decreases the root mean squared error by 24% compared to OI.
A Method for Elevated Ducts Refinement Based on Convolutional Neural Network
Authors: Zhu Xunyang , Yan Ke , Jiang Liquan , Tian Ling , Tian Bin 
Published: June 2024

AbstractElevated duct (EleD) is an abnormal atmospheric refraction structure with a suspended trapped layer. The precise and highly resolved elevated duct‐height‐based data (EleDH) is crucial for radio communication systems, especially in electromagnetic wave path loss prediction and EleDH‐producing systems. However, producing high‐resolution EleDH is challenging because of the massive details in the EleDH data. Direct and high‐time refinement procedures mostly lead to unrealistic outcomes. The study provides a Dense‐Linear convolutional neural network (DLCNN)‐based EleDH refinement technique based on the development of statistical downscaling and super‐resolution technologies. Additionally, the stack approach is used, and the refining order is taken into consideration to ensure precision in high‐time refinement and provide reliable outcomes. To demonstrate the strength of DLCNN in capturing complex internal characteristics of EleDH, a new EleD data set is first funded, which only contains the duct height. From this data set, we use the duct height as the core refinement of the EleD's trapped layer and the thickness of the trapped layer to ensure reliable duct height. Seven super‐resolution models are utilized for fair comparisons. The experimental results prove that the DLCNN has the highest refinement performance; also, it obtained excellent generalization capacity, where the minimum and maximum obtained Accuracy(20%), MAE, and RMSE were 85.22% ∓ 88.30%, 36.09 ∓ 45.97 and 8.68 ∓ 10.14, respectively. High‐resolution EleDH improves path loss prediction, where the minimum and maximum obtained bias were 2.37 ∓ 9.51 dB.
Role of Subauroral Polarization Streams in Deep Injections of Energetic Electrons Into the Inner Magnetosphere
Authors: Goyal R. , Zhao H. , Califf S. , Goldstein J. , Sarris T. E. 
Published: June 2024

AbstractThe electric fields of subauroral polarization streams (SAPS) have been suggested to affect energetic charged particles' dynamics in the inner magnetosphere, though their role on radiation belt electrons has never been properly quantified. A moderate geomagnetic storm on 2015‐09‐07 caused the deep injection of 10–100s of keV electrons in Earth's inner magnetosphere to low L* (L* < 4). Using a 2‐D test particle tracer, we present the effects of electric fields given by the Volland‐Stern model, a SAPS (Goldstein et al., 2005, https://doi.org/10.1029/2005ja011135) model, and a modified SAPS model on the energetic electron deep injections. The modified SAPS model reflects the SAPS electric field observations by the Van Allen Probes and is supported by Defense Meteorological Satellite Program observations. Simulations suggest that the SAPS electric field pushes 10–20 MeV/G electrons Earthward to L* ∼ 2.7 in 2.5 hr, much deeper compared to the Volland‐Stern electric field.
Resolving the Interpretation of Magnetic Coercivity Components From Backfield Isothermal Remanence Curves Using Unmixing of Non‐Linear Preisach Maps: Application to Loess‐Paleosol Sequences
Authors: Necula Cristian , Lascu Ioan , Panaiotu Cristian , Gheorghe Daniela 
Published: June 2024

AbstractUnmixing of remanent magnetization curves, either isothermal remanent magnetization (IRM) or backfield IRM, is widely used in rock magnetic and environmental magnetic studies to discriminate between magnetic coercivity components of different origins. However, the wide range of physical properties of natural magnetic particles gives rise to an ambiguous interpretation of these components. To reduce this ambiguity and provide a straightforward interpretation of coercivity components in terms of domain state, interactions, and constituent magnetic phases, we combined backfield IRM unmixing with unmixing of nonlinear Preisach maps for two typical mid‐latitude northern hemisphere loess‐paleosol sequences. Both backfield IRM and nonlinear Preisach maps unmixing are based on the same non‐parametric algorithm, and provide similar endmembers (EMs) in the two sections studied. The first EM (EM1) has a low median coercivity (∼21 mT) and is a non‐interacting single domain (SD) magnetite/maghemite of pedogenic origin. The second EM (EM2) has a moderate median coercivity (∼60 mT) and is a mixture of pseudo‐single domain/multidomain, SD magnetite/maghemite and non‐interacting SD hematite, all of eolian origin. The same EM1 found in both sections suggests that this component's grain size and coercivity are independent of pedogenesis intensity. The same EM2 indicates that a similar magnetic population is being transported and deposited, irrespective of the dust source area and loess granulometry. The approach outlined here provides strong evidence that non‐parametric backfield IRM unmixing isolates physically realistic EMs. Unmixing nonlinear Preisach maps elucidates these EMs in terms of domain states and their constituent magnetic phases.
Assessment of extremely premature lambs supported by the Extrauterine Environment for Neonatal Development (EXTEND)
Authors: Peers de Nieuwburgh Maureen , Dave Apeksha , Khan Sameer A. , Ngo Michelle , Hayes Kevin B. , Slipenchuk Matthew , Lieberman Evan , Youssef Mohanad R. , Crompton Dan , Choudhry Alia Mohsin , Guo Nan , Tian Zhiyun , Rychik Jack , Davey Marcus G. , Flake Alan W. 
Published: June 2024

Abstract

Background
Our team has previously reported physiologic support by the EXTra-uterine Environment for Neonatal Development (EXTEND) of 105 to 117 days gestational age (GA) lambs for up to 28 days with normal organ maturation. However, the fetal lamb brain matures more rapidly, requiring the study of 90-105 day GA fetal lambs to assess more neurodevelopmentally equivalent lambs to the 23–25 week GA extreme premature infant.

Methods
Extremely preterm lambs (90–95 days of GA) were delivered by C-section and supported by EXTEND. Estimated circuit flows were maintained at around 325 ml/kg/min. After support on EXTEND, MRI and histopathologic analysis were performed and compared to 105–112 days GA control lambs.

Results
The extremely preterm group includes 10 animals with a mean GA of 91.6 days, a mean weight at cannulation of 0.98 kg and a mean length of stay on EXTEND of 13.5 days (10–21 days). Hemodynamics and oxygenation showed stable parameters. Animals showed growth and physiologic cardiac function. MRI volumetric and diffusion analysis was comparable to controls. Histologic brain analysis revealed no difference between study groups.

Conclusion
EXTEND appears to support brain and cardiac development in an earlier gestation, less mature, lamb model.

Impact

Prolonged (up to 21 days) physiological support of extremely preterm lambs of closer neurodevelopmental equivalence to the 24–28 gestational week human was achieved using the EXTEND system.

EXTEND treatment supported brain growth and development in extremely preterm fetal lambs and was not associated with intraventricular hemorrhage or white matter injury.

Daily echocardiography demonstrated physiologic heart function, absence of cardiac afterload, and normal developmental increase in cardiac chamber dimensions.

This study demonstrates hemodynamic and metabolic support by the EXTEND system in the extremely preterm ovine model.
Fairer AI in ophthalmology via implicit fairness learning for mitigating sexism and ageism
Authors: Tan Weimin , Wei Qiaoling , Xing Zhen , Fu Hao , Kong Hongyu , Lu Yi , Yan Bo , Zhao Chen 
Published: June 2024

AbstractThe transformative role of artificial intelligence (AI) in various fields highlights the need for it to be both accurate and fair. Biased medical AI systems pose significant potential risks to achieving fair and equitable healthcare. Here, we show an implicit fairness learning approach to build a fairer ophthalmology AI (called FairerOPTH) that mitigates sex (biological attribute) and age biases in AI diagnosis of eye diseases. Specifically, FairerOPTH incorporates the causal relationship between fundus features and eye diseases, which is relatively independent of sensitive attributes such as race, sex, and age. We demonstrate on a large and diverse collected dataset that FairerOPTH significantly outperforms several state-of-the-art approaches in terms of diagnostic accuracy and fairness for 38 eye diseases in ultra-widefield imaging and 16 eye diseases in narrow-angle imaging. This work demonstrates the significant potential of implicit fairness learning in promoting equitable treatment for patients regardless of their sex or age.
Atmospheric emissions of hexachlorobutadiene in fine particulate matter from industrial sources
Authors: Zhao Chenyan , Yang Lili , Sun Yuxiang , Chen Changzhi , Huang Zichun , Yang Qiuting , Yun Jianghui , Habib Ahsan , Liu Guorui , Zheng Minghui , Jiang Guibin 
Published: June 2024

AbstractHexachlorobutadiene (HCBD) is a concerning chemical that is included in the United States Toxic Substances Control Act, and the Stockholm Convention. Knowledge of the sources of HCBD is insufficient and is pivotal for accurate inventory and implementing global action. In this study, unintentional HCBD release and source emission factors of 121 full-scale industrial plants from 12 industries are investigated. Secondary copper smelting, electric arc furnace steelmaking, and hazardous waste incineration show potential for large emission reductions, which are found of high HCBD emission concentrations of > 20 ng/g in fine particulate matter in this study. The highest HCBD emission concentration is observed for the secondary copper smelting industry (average: 1380 ng/g). Source emission factors of HCBD for the 12 industries range from 0.008 kg/t for coal fire power plants to 0.680 kg/t for secondary lead smelting, from which an estimation of approximately 8452.8 g HCBD emissions annually worldwide achieved. The carcinogenic risks caused by HCBD emissions from countries and regions with intensive 12 industrial sources are 1.0-80 times higher than that without these industries. These results will be useful for formulating effective strategies of HCBD control.
Plants interfere with non-self recognition of a phytopathogenic fungus via proline accumulation to facilitate mycovirus transmission
Authors: Hai Du , Li Jincang , Jiang Daohong , Cheng Jiasen , Fu Yanping , Xiao Xueqiong , Yin Huanran , Lin Yang , Chen Tao , Li Bo , Yu Xiao , Cai Qing , Chen Wei , Kotta-Loizou Ioly , Xie Jiatao 
Published: June 2024

AbstractNon-self recognition is a fundamental aspect of life, serving as a crucial mechanism for mitigating proliferation of molecular parasites within fungal populations. However, studies investigating the potential interference of plants with fungal non-self recognition mechanisms are limited. Here, we demonstrate a pronounced increase in the efficiency of horizontal mycovirus transmission between vegetatively incompatible Sclerotinia sclerotiorum strains in planta as compared to in vitro. This increased efficiency is associated with elevated proline concentration in plants following S. sclerotiorum infection. This surge in proline levels attenuates the non-self recognition reaction among fungi by inhibition of cell death, thereby facilitating mycovirus transmission. Furthermore, our field experiments reveal that the combined deployment of hypovirulent S. sclerotiorum strains harboring hypovirulence-associated mycoviruses (HAVs) together with exogenous proline confers substantial protection to oilseed rape plants against virulent S. sclerotiorum. This unprecedented discovery illuminates a novel pathway by which plants can counteract S. sclerotiorum infection, leveraging the weakening of fungal non-self recognition and promotion of HAVs spread. These promising insights provide an avenue to explore for developing innovative biological control strategies aimed at mitigating fungal diseases in plants by enhancing the efficacy of horizontal HAV transmission.
XIST dampens X chromosome activity in a SPEN-dependent manner during early human development
Authors: Alfeghaly Charbel , Castel Gaël , Cazottes Emmanuel , Moscatelli Madeleine , Moinard Eva , Casanova Miguel , Boni Juliette , Mahadik Kasturi , Lammers Jenna , Freour Thomas , Chauviere Louis , Piqueras Carla , Boers Ruben , Boers Joachim , Gribnau Joost , David Laurent , Ouimette Jean-François , Rougeulle Claire 
Published: June 2024

AbstractXIST (X-inactive specific transcript) long noncoding RNA (lncRNA) is responsible for X chromosome inactivation (XCI) in placental mammals, yet it accumulates on both X chromosomes in human female preimplantation embryos without triggering X chromosome silencing. The XACT (X-active coating transcript) lncRNA coaccumulates with XIST on active X chromosomes and may antagonize XIST function. Here, we used human embryonic stem cells in a naive state of pluripotency to assess the function of XIST and XACT in shaping the X chromosome chromatin and transcriptional landscapes during preimplantation development. We show that XIST triggers the deposition of polycomb-mediated repressive histone modifications and dampens the transcription of most X-linked genes in a SPEN-dependent manner, while XACT deficiency does not significantly affect XIST activity or X-linked gene expression. Our study demonstrates that XIST is functional before XCI, confirms the existence of a transient process of X chromosome dosage compensation and reveals that XCI and dampening rely on the same set of factors.
Semi-empirical model for Henry’s law constant of noble gases in molten salts
Authors: Lee Kyoung O. , Williams Wesley C. , McFarlane Joanna , Kropaczek David , de Wet Dane 
Published: June 2024

AbstractHenry’s law constant, which describes the proportionality of dissolved gas to partial pressure of free gas in liquid–gas equilibrium systems, can also be applied to mass transport applications. In this work, we investigated an approach for determining the solubility of noble gases in a molten salt liquid utilizing the equilibrium concept of Henry’s gas constant. Henry’s gas constant is described as a mathematical function dependent on the van der Waals radius of the noble gas and the temperature of the molten salt. The alteration in Gibbs free energy encompasses contributions from both surface and volume energies. Enthalpy and entropy are deduced from these surface and volume energies in the Gibbs free energy formulation. A comparative analysis was conducted between the conventional method and our proposed model. Moreover, useful chemical properties can be determined from examination of surface and volume energies. Our findings provide an accurate and general theory of Gibbs free energy that can be validated experimentally based on the model proposed herein. This work unifies the prediction of Henry gas constant and subsequently the entropy and enthalpy calculation for noble gases in a molten salt solution to a single functional form using van der Waals radius of the gas and temperature of the system. This functional form is then used to perform a multiple regression method to find two parameters corresponding to the surface energy and volume energy. These two parameters are consistent between all combinations of noble gas and molten salt.
A comparative analysis of clinical outcomes between conversion to mTOR inhibitor and calcineurin inhibitor reduction in managing BK viremia among kidney transplant patients
Authors: Cho Ara , Park Sunghae , Han Ahram , Ha Jongwon , Park Jae Berm , Lee Kyo Won , Min Sangil 
Published: June 2024

AbstractBK virus-associated nephropathy (BKVAN) exerts a substantial impact on allograft survival, however, the absence of robust clinical evidence regarding treatment protocols adds to the complexity of managing this condition. This study aimed to compare the two treatment approaches. The study population consisted of patients who underwent kidney transplantation between January 2016 and June 2020 at two tertiary hospitals in Korea. Patients diagnosed with BK viremia were evaluated based on their initial viral load and the treatment methods. The ‘Reduction group’ involved dose reduction of tacrolimus while the ‘Conversion group’ included tacrolimus discontinuation and conversion to sirolimus. A total of 175 patients with an initial viral load (iVL) ≥ 3 on the log10 scale were evaluated within two iVL intervals (3–4 and 4–5). In the iVL 4–5 interval, the Reduction group showed potential effectiveness in terms of viral clearance without statistically significant differences. However, within the iVL 3–4 interval, the Reduction group demonstrated superior viral clearance and a lower incidence of biopsy-proven acute rejection (BPAR) than the Conversion group. The renal function over 12 months after BKV diagnosis showed no statistically significant difference. Reducing tacrolimus compared to converting to mTORi would be a more appropriate treatment approach for BK viral clearance in kidney transplantation. Further research is warranted in a large cohort of patients.
Predictive value of lymphocyte subsets and lymphocyte-to-monocyte ratio in assessing the efficacy of neoadjuvant therapy in breast cancer
Authors: Zhang Hao , Li Yan , Liu Ya-Wen , Liu Ye-Gang , Chen Xin 
Published: June 2024

AbstractLymphocyte subsets are the most intuitive expression of the body’s immune ability, and the lymphocyte-to-monocyte ratio (LMR) also clearly reflect the degree of chronic inflammation activity. The purpose of this study is to investigate their predictive value of lymphocyte subsets and LMR to neoadjuvant therapy (NAT) efficacy in breast cancer patients. In this study, lymphocyte subsets and LMR were compared between breast cancer patients (n = 70) and benign breast tumor female populations (n = 48). Breast cancer patients were treated with NAT, and the chemotherapy response of the breast was evaluated using established criteria. The differences in lymphocyte subsets and LMR were also compared between pathological complete response (pCR) and non-pCR patients before and after NAT. Finally, data were analyzed using SPSS. The analytical results demonstrated that breast cancer patients showed significantly lower levels of CD3 + T cells, CD4 + T cells, CD4 + /CD8 + ratio, NK cells, and LMR compared to benign breast tumor women (P < 0.05). Among breast cancer patients, those who achieved pCR had higher levels of CD4 + T cells, NK cells, and LMR before NAT (P < 0.05). NAT increased CD4 + /CD8 + ratio and decreased CD8 + T cells in pCR patients (P < 0.05). Additionally, both pCR and non-pCR patients exhibited an increase in CD3 + T cells and CD4 + T cells after treatment, but the increase was significantly higher in pCR patients (P < 0.05). Conversely, both pCR and non-pCR patients experienced a decrease in LMR after treatment. However, this decrease was significantly lower in pCR patients (P < 0.05). These indicators demonstrated their predictive value for therapeutic efficacy. In conclusion, breast cancer patients experience tumor-related immunosuppression and high chronic inflammation response. But this phenomenon can be reversed to varying degrees by NAT. It has been found that lymphocyte subsets and LMR have good predictive value for pCR. Therefore, these markers can be utilized to identify individuals who are insensitive to NAT early on, enabling the adjustment of treatment plans and achieving precise breast cancer treatment.
Effects of intravenous inflammasome inhibitor (NuSepin) on suppression of proinflammatory cytokines release induced by cardiopulmonary bypass in swine model: a pilot study
Authors: Yoon Seung Zhoo , Park Jeong Jun , Jung Jae Seung , Kim Ji Eon , Lee Seung Hyong , Lee Jeonghoon , Kim Eung Hwi 
Published: June 2024

AbstractThe systemic inflammatory response syndrome can occur due to an inflammatory reaction to the release of cytokines, and it has been linked to the circulation of pro- and anti-inflammatory cytokines. The cardiopulmonary bypass (CPB) system is known to activate numerous inflammatory pathways. Applying CPB in large animals for an extended period may be useful as a controlled experimental model for systemic inflammatory responses. The authors hypothesized that 0.2 mg/kg NuSepin® would inhibit CBP-induced proinflammatory cytokine release, and attenuate CPB-induced vasoplegia. CPB was maintained for 2 h in 8 male Yorkshire pigs. Ten ml of saline was administered intravenously to the control group, while the study group received 10 ml of NuSepin® (0.2 mg/kg), before start of CPB. Blood samples were collected at four different time points to evaluating the level of cytokine (TNF-α, IL-1β, IL-6, IL-8) release during and after CBP. All vital signals were recorded as continuous waveforms using the vital recorder®. Our study demonstrated that IL-6 increased in both groups during CPB remained unchanged. However, in the Nusepin group, IL-6 levels rapidly decreased when CPB was stopped and the proinflammatory reaction subsided. Furthermore, the dose of norepinephrine required to maintain a mean pressure of 60 mmHg was also lower in the Nusepin group.