bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cover Picture: Eur. J. Immunol. 4/11
Authors: Jean‐Mairet Roberto Martín , López‐Menéndez Celia , Sánchez‐Ruiloba Lucía , Sacristán Sandra , Rodríguez‐Martínez María , Riol‐Blanco Lorena , Sánchez‐Mateos Paloma , Sánchez‐Madrid Francisco , Rodríguez‐Fernández José Luis , Campanero Miguel R. , Iglesias Teresa 
Published: March 2011

AbstractThe cover image of this issue consists of a microscopy image showing the morphological polarization of JHM1‐2.2 cells upon SDF1‐α‐stimulation, and is taken from Jean‐Mairet et al. (pp. 1035–1046). In this article, the authors investigate the role of the neuronal protein Kidins220/ARMS in T lymphocytes. The authors identify Kidins220/ARMS as a novel and important component of the uropod, where it establishes associations with critical T‐cell uropod components, and participates in the regulation of T‐cell motility. The image has been digitally manipulated and the colours have no significance.
Control Over the Crystallinity and Defect Chemistry of YVO4 Nanocrystals for Optimum Photocatalytic Property
Authors: Yang Liusai , Li Guangshe , Hu Wanbiao , Zhao Minglei , Sun Lang , Zheng Jing , Yan Tingjiang , Li Liping 
Published: March 2011

AbstractThis work reports on the kinetic control over the crystallinity and defect chemistry of YVO4 nanoparticles for the optimization of their photocatalytic performance. YVO4 nanoparticles were prepared at room temperature via a precipitation method and then annealed in air at selected temperatures ≤ 500 °C to tune their crystallinity and defect features. By systematic evaluation of the sample characterizations, it has been found that the as‐prepared samples crystallized in a pure tetragonal zircon‐type structure, and the surfaces of the particles are hydrated. Upon annealing, all YVO4 nanoparticles became dehydrated, which increased the crystallite sizes and improved the crystallinity of the samples. In contrast to many other oxide nanoparticles reported in literature, the increase in crystallite size of YVO4 nanoparticles led to a lattice expansion, as observed by enhancement of the covalency of the V–O bonds and the systematic shifts in the Raman frequency modes, owing to the generation of oxygen vacancies on particle surfaces. The presence of oxygen vacancies not only introduced a deep acceptor level in the electronic structure that gives rise to a slightly narrowed band‐gap and a broad visible emission, but also improved the photocatalytic activity of the particles; this latter effect is also a consesqence of the improved crystallinity of the samples.
Synthesis of the 5′‐Fluoro‐2′β‐methyl Analogues of Neplanocin
Authors: Kumamoto Hiroki , Kobayashi Marina , Kato Nobuyuki , Balzarini Jan , Tanaka Hiromichi 
Published: March 2011

AbstractSynthesis of the 5′‐fluoro‐2′‐β‐methyl analogues of neplanocin was carried out. Key intermediate cyclopentenone 19 was prepared from methyl α‐D‐mannopyranoside by a new approach consisting of ring‐closing metathesis, stereoselective introduction of the 2′‐methyl group, and intramolecular oxyselenenylation of the double bond as representative steps. Subsequent introduction of a fluorine atom at the 5′‐position of 19 was performed by electrophilic fluorination by using Selectfluor
Forecast Combination and Bayesian Model Averaging: A Prior Sensitivity Analysis
Authors: Feldkircher Martin 
Published: March 2011

ABSTRACTIn this study we evaluate the forecast performance of model‐averaged forecasts based on the predictive likelihood carrying out a prior sensitivity analysis regarding Zellner's g prior. The main results are fourfold. First, the predictive likelihood does always better than the traditionally employed ‘marginal’ likelihood in settings where the true model is not part of the model space. Secondly, forecast accuracy as measured by the root mean square error (RMSE) is maximized for the median probability model. On the other hand, model averaging excels in predicting direction of changes. Lastly, g should be set according to Laud and Ibrahim (1995: Predictive model selection. Journal of the Royal Statistical Society B 57: 247–262) with a hold‐out sample size of 25% to minimize the RMSE (median model) and 75% to optimize direction of change forecasts (model averaging). We finally apply the aforementioned recommendations to forecast the monthly industrial production output of six countries, beating for almost all countries the AR(1) benchmark model. Copyright © 2011 John Wiley & Sons, Ltd.
The expression of RKIP, RhoGDI, galectin, c‐Myc and p53 in gastrointestinal system of Cr(VI)‐exposed rats
Authors: Tsao Der‐An , Tseng Wei‐Chang , Chang Huoy‐Rou 
Published: March 2011

ABSTRACTHexavalent chromium (CrVI) is considered to be a risk factor in the formation of human cancer. Raf kinase inhibitor protein (RKIP), Rho‐GDIα, galectin, c‐Myc and p53 play important roles in cancer formation. The purpose of this study was to determine if Cr(VI) induces the formation of gastrointestinal cancer. We explored the expression of RKIP, Rho‐GDIα, galectin, c‐Myc and p53 in the colon and stomach in rats exposed to chromium (CrVI). Thirty Wistar rats were divided into six groups which were chronically fed with 250, 500, 750, 1000 and 1250 ppm Na2Cr2O7 and water for 60 days. The level of Cr(VI) was determined by electrothermal atomic absorption spectrometry. The expression of RKIP, Rho‐GDIα, galectin, c‐Myc and p53 of stomach and colon was measured by western blot. The gene expression of RKIP, Rho‐GDIα, galectin, c‐Myc and p53 of the stomach and colon was determined by RT‐PCR. The results showed that the expression of p53 and Rho‐GDIα was decreased in the stomach and colon of rats with Cr(VI) treatment. The expression of RKIP was decreased in the stomach and colon of rats treated with high‐dose Cr(VI). The expression of c‐Myc and gelectin‐1 was increased in the stomach and colon of rats with Cr(VI) treatment. We concluded that the anomalous expression of RKIP, Rho‐GDIα, galectin, c‐Myc and p53 might be a dangerous index of cancer formation in the stomach and colon of rats with Cr(VI) exposure. Copyright © 2011 John Wiley & Sons, Ltd.
Fabrication of nano‐hydroxyapatite on electrospun silk fibroin nanofiber and their effects in osteoblastic behavior
Authors: Wei Kai , Li Yuan , Kim Kyu‐Oh , Nakagawa Yuya , Kim Byoung‐Suhk , Abe Koji , Chen Guo‐Qiang , Kim Ick‐Soo 
Published: March 2011

AbstractIn this study, a novel tissue engineering scaffold material of electrospun silk fibroin/nano‐hydroxyapatite (nHA) biocomposite was prepared by means of an effective calcium and phosphate (Ca‐P) alternate soaking method. nHA was successfully produced on regenerated silk fibroin nanofiber as a substrate within several minutes without any pretreatments. The morphologies of both nonmineralized and mineralized nanofibers were analyzed using a field‐emission scanning electron microscopy (FESEM). The crystallographic phases of the nHA were analyzed using X‐ray diffraction (XRD). Fourier transform infrared (FTIR) spectrophotometer and thermogravimetry analyses (TGA) were employed to determine the type of functional groups and the amount of nHA presenting in the silk/nHA biocomposite nanofibers, respectively. The osteoblastic activities of this novel nanofibrous biocomposite scaffold were also investigated by employing osteoblastic‐like MC3T3‐E1 cell line. The cell functionality such as alkaline phosphatase (ALP) activity was ameliorated on mineralized nanofibers. All these results indicated that this silk/nHA biocomposite scaffold material may be a promising biomaterial for bone tissue engineering. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2011.
Incorporation of biomimetic matrix molecules in PEG hydrogels enhances matrix deposition and reduces load‐induced loss of chondrocyte‐secreted matrix
Authors: Roberts Justine J. , Nicodemus Garret D. , Giunta Suzanne , Bryant Stephanie J. 
Published: March 2011

AbstractPoly(ethylene glycol) (PEG) hydrogels offer numerous advantages in designing controlled 3D environments for cartilage regeneration, but offer little biorecognition for the cells. Incorporating molecules that more closely mimic the native tissue may provide key signals for matrix synthesis and may also help in the retention of neotissue, particularly when mechanical stimulation is employed. Therefore, this research tested the hypothesis that exogenous hyaluronan encapsulated within PEG hydrogels improves tissue deposition by chondrocytes, while the incorporation of Link‐N (DHLSDNYTLDHDRAIH), a fragment of link protein that is involved in stabilizing hyaluronan and aggrecan in cartilage, aids in the retention of the entrapped hyaluronan as well as cell‐secreted glycosaminoglycans (GAGs), particularly when dynamic loading is employed. The incorporation of Link‐N as covalent tethers resulted in a significant reduction, ∼60%, in the loss of entrapped exogenous hyaluronan under dynamic stimulation. When chondrocytes were encapsulated in PEG hydrogels containing exogenous hyaluronan and/or Link‐N, the extracellular matrix (ECM) analogs aided in the retention of cell‐secreted GAGs under loading. The presence of hyaluronan led to enhanced deposition of collagen type II and aggrecan. In conclusion, our results highlight the importance of ECM analogs, specifically hyaluronan and Link‐N, in matrix retention and matrix development and offer new strategies for designing scaffolds for cartilage regeneration. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011.
Development of chondroitin sulfate encapsulated PLGA microsphere delivery systems with controllable multiple burst releases for treating osteoarthritis
Authors: Jiang Tao , Petersen Rebecca R. , Call Gazell , Ofek Gidon , Gao Jizong , Yao Jian Q. 
Published: March 2011

AbstractThe purpose of the study was to design and develop unique drug delivery systems with controllable multiple burst releases of drugs for treating osteoarthritis. Chondroitin sulfate (CS) was encapsulated into four types of PLGA materials, that is, PLGA 50:50, PLGA 65:35, PLGA 75:25, and PLGA 85:15. The effects of microsphere size and various combinations of blend PLGA microspheres on CS release were investigated. The cytotoxicity of the CS‐encapsulated microspheres was investigated according to the ISO 10993 guideline. Our study showed that the encapsulation efficiency of CS into PLGA 50:50 microspheres varied with the size of microspheres; however, the encapsulation efficiencies of CS into PLGA microspheres were independent of the types of PLGA materials. The size of PLGA microspheres was shown to affect the rate of CS release. With the increase of microsphere size from 75–150 μm to 300–355 μm, the initial CS release decreased. Further increase in microsphere size led to an increase in the initial CS release. In addition, combination of different types of PLGA microspheres was shown to be capable of achieving multiple burst CS releases. Moreover, the CS encapsulated PLGA microspheres were shown to be non‐cytotoxic. This study proved the concept of multiple burst drug releases that were achieved by encapsulating CS into different types of PLGA microspheres and delivering CS from systems consisting of mixed types of PLGA microspheres, which may be applied to treat osteoarthritis by mimicking multiple intra‐joint injection of therapeutic agents. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.
A forward loop between glioma and microglia: Glioma‐derived extracellular matrix‐activated microglia secrete IL‐18 to enhance the migration of glioma cells
Authors: Yeh Wei‐Lan , Lu Dah‐Yuu , Liou Houng‐Chi , Fu Wen‐Mei 
Published: March 2011

AbstractThe mediators and cellular effectors of inflammation are important constituents of the local environment of tumors. In some occasions, oncogenic changes induce an inflammatory microenvironment that promotes the progression of tumors. In gliomas, the presence of microglia may represent tumor‐related inflammation and microglia activation, and subsequent inflammatory responses may influence tumor growth and metastasis. Here, we found that C6 glioma—but not primary astrocyte‐derived extracellular matrix (ECM) could activate microglia, including primary microglia and BV‐2 cell line, and activated microglia‐secreted interleukin (IL)‐18, a potent inflammatory cytokine of the IL‐1 family, to promote C6 migration. In addition, by coating purified ECM components, it was found that secretion of IL‐18 by activated microglia was enhanced when microglia encountered with fibronectin and vitronectin. Furthermore, IL‐18‐induced C6 migration and microfilament disassembly were antagonized by iNOS inhibitor, guanylate cyclase inhibitor, and protein kinase G inhibitor. Taken together, these results indicate that IL‐18 secreted by microglia, which was activated by C6 glioma‐derived ECM, enhanced migration of C6 glioma through NO/cGMP pathway. J. Cell. Physiol. 227: 558–568, 2012. © 2011 Wiley Periodicals, Inc.
Role of FSH and triiodothyronine in Sertoli cell development expressed by formation of connexin 43‐based gap junctions
Authors: Marchlewska Katarzyna , Kula Krzysztof , Walczak‐Jedrzejowska Renata , Oszukowska Elzbieta , Filipiak Eliza , Slowikowska‐Hilczer Jolanta 
Published: March 2011

AbstractFollicle‐stimulating hormone (FSH) and triiodothyronine (T3) are known regulatory factors of spermatogenesis initiation. Connexin 43 (Cx43) is the most ubiquitous constitutive protein of gap junctions in the testis. This study evaluates the effects of the hyperstimulation of FSH and T3 during testicular maturation on Cx43 expression in the testis. The newborn, male Wistar rats were divided randomly into four experimental groups: FSH group—daily injections of FSH 7.5 IU/animal; T3 group—100 µg T3/kg body weight; FSH+T3 group—both substances; A control group—received vehicles in the same volume. Proliferating cell nuclear antigen immunohistochemistry and toluidine blue staining were used to determine the germ cell proliferation and degeneration. Cx43 immunolocalization was evaluated to find Cx43 maturational changes. Under FSH treatment, the proliferation rate was high so the total number of Sertoli cells increased with a low level of degeneration and lumen formation. T3 stimulation evoked a reduction in the proliferation rate and a decrease in Sertoli cell number but with intensive formation of lumen. T3+FSH inhibited the proliferation rate and stimulated lumen formation together with degeneration, which negatively influenced the number of germ cells in the seminiferous epithelium. We conclude that T3 action seems to be particularly connected with the maturation of Cx43 gap junctions. FSH stimulates maturation of Sertoli cell function, but this effect may take place regardless of the presence of Cx43‐dependent intercellular communication. The hyperstimulation of both FSH and T3 damages Cx43 connections and hence evokes regressional changes in the seminiferous epithelium. J. Exp. Zool. 315:329–336, 2011. © 2011 Wiley‐Liss, Inc.
“Don't mourn; organize” institutions and organizations in the politics and economics of growth and poverty‐reduction
Authors: Leftwich Adrian , Sen Kunal 
Published: March 2011

AbstractIt is commonly argued that ‘institutions matter’ for growth and poverty reduction. While recognising the importance of institutions, it is necessary to go ‘beyond institutions’ in understanding the factors that promote growth and poverty reduction. This paper draws on the research findings of the IPPG Research Consortium (Improving Institutions for Pro‐Poor Growth), some of which are included in this issue, to make the following arguments. We argue, first, that the ways in which economic, political and social institutions interact are crucial in shaping pro‐poor development outcomes. Secondly, the establishment of effective institutions also requires the building and strengthening of effective social, political and economic organizations, across sectors and issue areas, which can push for, negotiate, implement and monitor locally appropriate and legitimate institutional arrangements if the aim of poverty reduction is to have sustained traction as a policy goal. Copyright © 2011 John Wiley & Sons, Ltd.
Access to public infrastructure, institutional thickness and pro‐poor growth in Rural Peru
Authors: Escobal Javier A. , Ponce Carmen 
Published: March 2011

AbstractUsing panel data from Rural Peru we explore the role of institutional thickness on furthering the effects of key infrastructure investments on pro‐poor growth. Institutional thickness is characterised here as the result of a combination of four interrelated characteristics: (a) the presence of organisations signalling collective action; (b) the degree of productive asset inequality; (c) the degree of inequality of opportunities and (d) the degree of political fragmentation. The paper shows that institutionally thick environments do contribute to amplify the effects of public infrastructure on income growth for those belonging to the poorest tercile, allowing poverty to be more responsive to growth. Copyright © 2011 John Wiley & Sons, Ltd.
Petroleomics: advanced molecular probe for petroleum heavy ends
Authors: Hsu Chang S. , Hendrickson Christopher L. , Rodgers Ryan P. , McKenna Amy M. , Marshall Alan G. 
Published: March 2011

AbstractTo look into complex mixtures of petroleum heavy ends at the molecular level, ultra high‐resolution mass spectrometry, i.e. resolving power > 50 000, is needed to resolve overlapping components for accurate determination of molecular composition of individual components. Recent progress in Fourier transform ion cyclotron resonance mass spectrometry (FT‐ICR MS) incorporated with soft ionization techniques adaptable to liquid chromatography enables analysis of petroleum high ends, i.e., heavy oils, residua and asphaltenes. FT‐ICR MS at the Future Fuels Institute of Florida State University and the National High Magnetic Field Laboratory (NHMFL) routinely provides 1 000 000 resolving power at 400 Da, with root mean square (rms) mass measurement accuracy between 30 and 500 ppb for 5000–30 000 identified species in a single mass spectrum. Phase correction of the detected ion signal increases resolving power 40–100%, improving mass accuracy up to twofold. Overlapping ionic species that differ in mass by as little as one electron mass (548 µDa) can be resolved. A database of more than 100 000 components of different elemental composition has been generated at NHMFL. Copyright © 2011 John Wiley & Sons, Ltd.
Ultraviolet photodissociation of chromophore‐labeled oligosaccharides via reductive amination and hydrazide conjugation
Authors: Ko Byoung Joon , Brodbelt Jennifer S. 
Published: March 2011

AbstractThe fragmentation patterns of hydrazide‐conjugated and reductively aminated oligosaccharides, including lacto‐N‐fucopentaoses and lacto‐N‐difucohexaoses, produced on collisionally induced dissociation (CID) and ultraviolet photodissociation (UVPD) in a quadrupole ion trap are presented. The two derivatization methods generate different cross‐ring cleavages on UVPD and CID. UVPD of hydrazide‐conjugated oligosaccharides yield predominant 2, 4A‐type cross‐ring cleavage ions. In contrast, UVPD of aminated oligosaccharides results mainly in 0, 1A‐type ions. Moreover, more extensive dual‐cleavage pathways (i.e. internal fragment ions) were observed on UVPD. Copyright © 2011 John Wiley & Sons, Ltd.
Ionic liquid‐assisted electrospray ionization of polysaccharides
Authors: Chang Yu‐Ling , Lee Yuan‐Chun , Yang Wen‐Bin , Chen Chung‐Hsuan 
Published: March 2011

AbstractIn this work, we give the report of significant detection sensitivity improvement of electrospray ionization (ESI) mass spectra of polysaccharides by adding various ionic liquid compounds into samples. Mass spectra obtained were greatly simplified and appeared to be similar to spectra from matrix‐assisted laser desorption/ionization due to the narrow charge number distribution. Mass spectra of polysaccharides with the attachment of either anion or cation of ionic liquid compounds were observed. No protonated or deprotonated polysaccharide ions were detected when ionic liquid compounds were added into samples. Little alkali‐attached polysaccharide ions were observed. Ionic liquid‐assisted ESI (ILA‐ESI) mass spectrometry has significantly improved the detection sensitivity of large neutral polysaccharide compounds. Copyright © 2011 John Wiley & Sons, Ltd.
Nebulization ionization and desorption ionization analysis of reactive organofunctionalized silanes in nanofilm products
Authors: Nørgaard Asger W. , Janfelt Christian , Benassi Mario , Wolkoff Peder , Lauritsen Frants R. 
Published: March 2011

AbstractThree different and recently developed desorption ionization techniques, transmission‐mode desorption electrospray ionization (TM‐DESI), low temperature plasma (LTP) ionization and nano‐assisted laser desorption ionization (NALDI), are compared with electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) for the analysis of two nanofilm products (NFPs) for surface coating, which contain hydrolysates and condensates of organo‐functionalized silanes. The NFPs were characterized in different states from the liquid phase to the fully formed surface film. The LTP spectra were dominated by the silanes, while the corresponding di‐, tri‐ and tetrasiloxanes were common in ESI, APCI and TM‐DESI. This indicates readily condensation of the silanes during the ESI and APCI ionization processes leading to the observed siloxanes. NALDI showed larger siloxane structures than the other techniques, indicating film formation on the NALDI target. Real‐time monitoring of the film formation on a glass surface by LTP showed a decreasing abundance of the silanes, while the abundances of the di‐, tri and tetrasiloxanes increased significantly within the first 100 s. LTP was superior in showing the non‐reacted content of the NFPs, while ESI, APCI and TM‐DESI were characterized by artefact formation of siloxanes. NALDI was ideal for showing the siloxane structures of the formed film. The applicabilities of each of the ionization techniques were examined, showing the advantage of utilizing more than one ionization technique for the analysis of reactive species. Copyright © 2011 John Wiley & Sons, Ltd.
Multi‐ion quantitative mass spectrometry by orthogonal projection method with periodic signal of electrostatic ion beam trap
Authors: Sun Qi , Gu Changxin , Ding Li 
Published: March 2011

AbstractIn this article, orthogonal projection method (OPM) is introduced which could perform multi‐ion quantitative MS with signal of electrostatic ion beam trap (EIBT), and its application has been demonstrated by numerical modeling. To acquire periodic current signal, a model of EIBT with cylindrical‐detector is set up to simulate ions' oscillatory motion. Whereafter, OPM is introduced and applied for quantitative MS with sampling time being as short as 200 µs. Comparing with fast Fourier transform (FFT), the MS acquired by OPM is characterized by a more readable spectrum, a much shortened sampling time and the ability to do quantitative analysis. Within the optimum sampling time range, quantitative MS could be performed with accuracy of over 90%. It is found that the lower limit and the upper limit of the optimum sampling time range are all proportional to $M^{3/2}\big/\delta M$ and its relation is specified by linear regression. Aided by the results of FFT, OPM is applied to a compound tested signal induced by three kinds of ions. It shows that OPM could be performed respectively to each kind of ions without interference from other component of the signal. The resolving power acquired by OPM is about 75 000 with sampling time as short as 10 ms, and the quantitative result that acquired is quite accurate. Copyright © 2011 John Wiley & Sons, Ltd.