bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing Antibiotic Use in Older Adults Through Digital Health Initiatives
Authors: Bear Michael , Aungst Timothy , Herren Janelle , Mosaffa Shayan , Liu Songyun , Riley Sharnett 
Published: February 2025

Abstract

Purpose of Review
The goal of this paper is to explore the impact of digital health technologies (DHTs) on antibiotic utilization in older adults. The paper aims to address how these technologies are implemented to improve antibiotic stewardship, address age-specific challenges, and manage infection risks in this vulnerable population while assessing limitations, ethical issues, educational barriers, and potential benefits.

Recent Findings
Recent research highlights the potential of DHTs to enhance antibiotic use and infection management among older adults. Telehealth has increased access to infectious disease specialists and stewardship services, with promising outcomes in older adults. DHTs like remote monitoring, telemedicine, and AI-driven surveillance may advance outbreak response, predict resistance patterns, and personalize therapy. Home diagnostic kits and physiological sensors offer convenience but face challenges in accuracy, patient education, and health literacy.

Summary
Further research is needed to validate and optimize these technologies for this population. Risks such as antibiotic overprescribing due to virtual diagnostic limitations need additional research and ethical consideration of DHTs in older adults require more attention and study and educational and technical barriers must be addressed to maximize use and benefits of DHTs in older adults.
Cultural responsiveness, Positive Behaviour Interventions and Supports, and the settler colonial state
Authors: Delany Tim , Rudolph Sophie , McKay-Brown Lisa 
Published: February 2025

Abstract
Positive Behaviour Interventions and Supports (PBIS) is a whole school change framework and approach to learning and engagement that originated in the United States (US) and is now implemented around the world. Such a framework requires consideration of cultural responsiveness, particularly in settler colonial states such as the US and Australia. This article examines guidance for improving culturally responsive practice in the PBIS Cultural Responsiveness Field Guide: Resources for Trainers and Coaches (the Guide), a key resource for educators working with students from culturally diverse backgrounds. We employ critical policy analysis and Decolonising Race Theory (DRT) to analyse and discuss the possibilities and consequences of the Guide for educators who are working with Indigenous students in settings that inherit and uphold structural racisms endemic to colonisation. We identify possible intended and unintended effects of the Guide in settler colonial contexts, particularly Australia. Our critical analysis using DRT highlighted some silences and erasures within the PBIS cultural responsiveness advice. The tendency towards othering, binary thinking, and maintenance of the cultural status quo was also apparent. Through this analysis we show how DRT offers rich opportunities for unsettling settler colonial hegemonies in PBIS and in education more broadly.
Performance Analysis of NoC and WiNoC in Multicore System Architectures
Authors: Lit Asrani , Suhaili Shamsiah , Kipli Kuryati , Rajaee Nordiana 
Published: February 2025

Abstract
Wireless network-on-chip has emerged as an innovative and effective solution to meet the growing demands for efficient data communication in multi-core processors. It offers an alternative approach to overcoming scalability challenges in communication systems. This study offers an in-depth performance assessment of network-on-chip and wireless network-on-chip multicore system architectures in the context of a 64-core and 256-core system. The analysis includes four synthetic traffic patterns—random, shuffle, butterfly, and transpose—giving a detailed overview of how each impacts system performance. Key metrics such as data transmission delay, network throughput efficiency, and energy consumption were thoroughly analyzed. To support our conclusions, simulations were conducted on 64-core and 256-core for NoC and WiNoC multicore system. The results highlight the effectiveness of the WiNoC multicore system design, demonstrating its advantage in network performance based on the simulations carried out with Noxim. WiNoC’s enhanced ability to handle higher traffic loads and achieve lower latency across all traffic profiles showcases its advantage over the traditional NoC setup.
Grand funerary stelae (2nd–3rd c. AD) of the microregion of Musti (El Krib, Tunisia): an iconographic and epigraphic analysis and the latest eco-factual data (2019–2023)
Authors: Kłodziński Karol , Abid Mohammed , Badura Monika , Iwaszczuk Urszula , Hajji Jamel , Waliszewski Tomasz 
Published: February 2025

Abstract
New research in the microregion of Musti (El Krib) in N Tunisia in 2019–2023 has revealed unpublished 2nd–3rd-century AD funerary monuments featuring rich iconography, including a female figure beside the altar and two pigs. These items and other published epigraphic and anepigraphic monuments from the fertile microregion stand out from other tombstones in Roman Africa. Both the type of monument and its relief decoration distinguish these objects. A rare holistic approach, combining historical, epigraphic and iconographic analyses with the results of archaeobotanical and archaeozoological research, will enhance our understanding of the history and agriculture of the Musti microregion and this part of Proconsular Africa during the early Roman Empire.
Prevalence and determinants of wasting and overweight in Brazilian children between 6- 59 months: Brazilian National Survey on Child Nutrition (ENANI-2019)
Authors: Farias D. R. , Anjos L.A. , Berti T. L. , Santos N. H. A. , Andrade P. G. , de Freitas M. B. , da Costa J. L. , Oliveira N. , Lacerda E. M. A. , Carneiro L. B. V. , Schincaglia R. M. , Normando P. , de Castro I. R.R. , Kac G. 
Published: February 2025

Abstract
Understanding the determinants of malnutrition is pivotal for public health interventions. This study aimed to identify socio-economic, demographic, dietary, and maternal determinants of wasting and overweight among Brazilian children between 6–59 months. Data from the Brazilian National Survey on Child Nutrition were analyzed (n=11,789). Children’s weight-for height Z scores were calculated according to the WHO growth standard and classified as wasting (Z < -2), normal weight (-2 ≤ Z ≤1), overweight risk (1 < Z ≤ 2), and overweight (Z > 2). Socio-economic, demographic, dietary, and maternal covariables were considered. Adjusted multinomial logistic regression (odds ratio (OR) and 95% confidence interval (95% CI) was employed. The prevalence of overweight and wasting was 9.5% and 2.6%, respectively. In the adjusted model, younger age (6-23 months: OR: 1.7; 95%CI: 1.3; 2.2), consumption of ≥ 5 ultra-processed food groups (OR: 1.8; 95%CI: 1.1; 3.1), maternal underweight (OR: 0.4; 95%CI: 0.2; 0.9), overweight (OR: 1.5; 95%CI: 1.2; 1.9) and mild food insecurity (OR: 0.8; 95%CI: 0.6; 1.0) were associated with child overweight. The Brazilian Northeast (OR: 4.9; 95%CI: 2.1; 11.3), Southeast (OR: 7.1; 95%CI: 3.0; 16.6), South (OR: 4.7; 95%CI: 1.8; 12.1), Midwest regions (OR: 2.7; 95%CI: 1.2; 6.2) and maternal underweight (OR: 5.4; 95%CI: 2.7; 10.7) were associated with wasting. Overweight in Brazil is prevalent among children between 6-59 months, while wasting is not a major public health problem. The main determinants of these Brazilian children's nutritional status were age, ultra-processed food consumption, and maternal nutritional status.
Studying Multi-Level Systems with Cross-Level Data: Introducing Three Integrated Datasets
Authors: Röth Leonce , Saldivia Gonzatti Daniel , Kaftan Lea , Kaiser André 
Published: February 2025

Abstract
Most political systems consist of multiple layers. Yet datasets are predominantly situated at a single territorial tier, encouraging methodological nationalism, regionalism, and localism. We present three new integrated datasets that include electoral, institutional, ideological, and government composition data on the country and regional level (RD|CED, RED and RPSD). With this data, we cover 337 country elections on the regional level, 2,226 regional elections, and 2,825 regional cabinets in 365 regions of 21 countries from 1941 to 2019, accounting for 800 political parties and their ideological positions. Combined, these data complement and extend existing datasets and facilitate the study of political interaction across levels. Data are available at http://multi-level-cross-level-politics.eu/ or can be accessed through the Havard Dataverse repository. We conclude with an agenda for future cross-level studies.
Homeland Is Where the Soul Resides: Travel Prayer, Passports, and Nation in the Western Indian Ocean
Authors: Limbert Mandana 
Published: February 2025

Abstract
This article examines conflicting notions of political home or homeland (waṭan) in the early twentieth-century Western Indian Ocean. In a period of colonial consolidation and shifts in trans-oceanic mobility, determining political belonging took on urgency for both British officials and Omani intellectuals and migrants. This article examines how, in contrast to both anti-colonial nationalists and British colonial officials, homeland in Omani religious scholarship was neither bounded territorially nor articulated through origins or subjecthood. Yet, it was spatial, affective, and hierarchically determined. And, it was manifest, embodied, and performed in the daily requirements of prayer. Spatial but not territorial, necessary but personally, hierarchically, and affectively decided, this pious notion of homeland has for the most part been replaced by the nation-state form. Yet, legacies of attachment to waṭan outside the bounded territorial model occasionally surface, operating as a simultaneous, but not synonymous, expression of political and personal belonging.
Fifty years of astrobiology: mapping researcher communities with topic-based network analyses
Authors: Malaterre Christophe , Lareau Francis 
Published: February 2025

Abstract
Astrobiology is often defined as the study of the origin, evolution, distribution and future of life on Earth and in the Universe and thought of as a discipline. In practice though, the delineation of astrobiology-related research and corresponding groups of researchers is far from straightforward. Here, we propose to apply text-mining methods to identify researcher communities depending on thematic similarities in their published works. After fitting a latent Dirichlet allocation topic model to the complete article corpus of three flagship journals in the field – Origins of Life and Evolution of Biospheres (1968–2020), Astrobiology (2001–2020), the International Journal of Astrobiology (2002–2020) – and computing author topic profiles, researcher communities are inferred from topic similarity networks to which community detection is applied. Such semantic social networks reveal, as we call them, ‘hidden communities of interest’ that gather researchers who publish on similar topics. The evolution of these communities is also mapped through time, bringing to light the significant shifts that the discipline underwent in the past 50 years.
A Novel Topography‐Based Approach for Real‐Time Flood Inundation Mapping
Authors: Shi Pengfei , Lyu Kai , Li Zhenya , Yang Tao , Xu Chong‐Yu , Hao Xiaobo , Xiao Jiaqing 
Published: February 2025

AbstractThe occurrence frequency and catastrophe caused by flooding are increasing rapidly, highlighting the importance of real‐time impact‐based forecasting. However, traditional approaches primarily based on hydrodynamic models need large computational cost and generally fail to achieve real‐time flood mapping, especially for large‐scale watersheds. In this work, a novel, simple and convenient approach called Topography‐based Flood Inundation Mapping (TOPFIM) is developed to achieve rapid and accurate flood mapping. TOPFIM is characterized by an adaptive river segmentation method and a dynamic inundation volume allocation approach adhering full water volume constraint. The proposed approach is applied to the upper reaches of the Le'an River basin, China, and HEC‐RAS is employed as the benchmark for comparison. The results demonstrate that TOPFIM's simulation accuracy for inundation extent approaches that of hydrodynamic models, with an averaged critical success index of 0.83 and hit rate of 0.90 compared to HEC‐RAS's simulation. Moreover, TOPFIM generates flood inundation mapping prediction within 10 s rather than hours required by conventional hydrodynamic models. It signifies a pivotal practical enhancement that has the potential to effectively preserve lives and protect assets in times of flood emergencies. Overall, as a simple and convenient tool, TOPFIM demonstrates its potential for real‐time flood inundation mapping and risk analysis.
Novel FBN1 intron variant causes isolated ectopia lentis via in-frame exon skipping
Authors: Shimizu Norihiro , Mashimo Yoichi , Yokouchi Hirotaka , Nishio Yosuke , Sawai Setsu , Ichikawa Tomohiko , Ogi Tomoo , Baba Takayuki , Onouchi Yoshihiro 
Published: February 2025

Abstract
Mutations in fibrillin-1 (FBN1) cause various clinical conditions, such as Marfan syndrome (MFS). However, the genotype–phenotype relationships underlying MFS and other conditions relevant to FBN1 mutations have not been fully elucidated. We performed whole-exome sequencing on three participants, including an affected mother–daughter pair, in a three-generation Japanese family with isolated ectopia lentis (IEL). The sequencing identified a novel single-nucleotide variant (c.1327+3A>C) in intron 11 of FBN1 that was shared between the two patients. We confirmed the co-segregation of the variant with IEL in two additional affected relatives in the family. The Combined Annotation-Dependent Depletion score of the variant was 26.1, which was indicated by SpliceAI to influence splicing, with a score of 0.93. Reverse transcription-polymerase chain reaction (RT-PCR) of mRNAs isolated from peripheral blood mononuclear cells revealed aberrant bands in all four affected individuals. Subsequent sequencing revealed that these bands originated from FBN1 transcripts lacking exon 11. The causality of the variant in the skipping of exon 11, which results in an in-frame deletion of 60 amino acids corresponding to the “hinge” region of FBN1 protein, was confirmed in a minigene experiment. Interestingly, the same result was observed for a minigene for c.1327+1G>A, a variant previously identified in two unrelated EL families without MFS manifestations. These results suggest that the c.1327+3A>C mutation in FBN1 likely leads to IEL. The findings expand our knowledge of FBN1 and provide insights into FBN1-related diseases.
ACOT12, a novel factor in the pathogenesis of kidney fibrosis, modulates ACBD5
Authors: Kim Ee Hyun , Kim Mi Kyung , Choe MiSun , Ryu Ji Hyun , Pak Eun Seon , Ha Hunjoo , Jin Eun-Jung 
Published: February 2025

Abstract
Lipid metabolism, particularly fatty acid oxidation dysfunction, is a major driver of renal fibrosis. However, the detailed regulatory mechanisms underlying this process remain unclear. Here we demonstrated that acyl-CoA thioesterase 12 (Acot12), an enzyme involved in the hydrolysis of acyl-CoA thioesters into free fatty acids and CoA, is a key regulator of lipid metabolism in fibrotic kidneys. A significantly decreased level of ACOT12 was observed in kidney samples from human patients with chronic kidney disease as well as in samples from mice with kidney injuries. Acot12 deficiency induces lipid accumulation and fibrosis in mice subjected to unilateral ureteral obstruction (UUO). Fenofibrate administration does not reduce renal fibrosis in Acot12

−/−
mice with UUO. Moreover, the restoration of peroxisome proliferator-activated receptor α (PPARα) in Acot12

−/−

Pparα

−/−
kidneys with UUO exacerbated lipid accumulation and renal fibrosis, whereas the restoration of Acot12 in Acot12

−/−

Pparα

−/−
kidneys with UUO significantly reduced lipid accumulation and renal fibrosis, suggesting that, mechanistically, Acot12 deficiency exacerbates renal fibrosis independently of PPARα. In Acot12

−/−
kidneys with UUO, a reduction in the selective autophagic degradation of peroxisomes and pexophagy with a decreased level of ACBD5 was observed. In conclusion, our study demonstrates the functional role and mechanistic details of Acot12 in the progression of renal fibrosis, provides a preclinical rationale for regulating Acot12 expression and presents a novel means of preventing renal fibrosis.
Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis
Authors: Lim Bryce , Kamal Aryan , Gomez Ramos Borja , Adrian Segarra Juan M. , Ibarra Ignacio L. , Dignas Lennart , Kindinger Tim , Volz Kai , Rahbari Mohammad , Rahbari Nuh , Poisel Eric , Kafetzopoulou Kanela , Böse Lio , Breinig Marco , Heide Danijela , Gallage Suchira , Barragan Avila Jose E. , Wiethoff Hendrik , Berest Ivan , Schnabellehner Sarah , Schneider Martin , Becker Jonas , Helm Dominic , Grimm Dirk , Mäkinen Taija , Tschaharganeh Darjus F. , Heikenwalder Mathias , Zaugg Judith B. , Mall Moritz 
Published: February 2025

Abstract
Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. While transcription master regulators induce lineage-specific genes to restrict plasticity, it remains unclear whether plasticity is actively suppressed by lineage-specific repressors. Here we computationally predict so-called safeguard repressors for 18 cell types that block phenotypic plasticity lifelong. We validated hepatocyte-specific candidates using reprogramming, revealing that prospero homeobox protein 1 (PROX1) enhanced hepatocyte identity by direct repression of alternative fate master regulators. In mice, Prox1 was required for efficient hepatocyte regeneration after injury and was sufficient to prevent liver tumorigenesis. In line with patient data, Prox1 depletion caused hepatocyte fate loss in vivo and enabled the transition of hepatocellular carcinoma to cholangiocarcinoma. Conversely, overexpression promoted cholangiocarcinoma to hepatocellular carcinoma transdifferentiation. Our findings provide evidence for PROX1 as a hepatocyte-specific safeguard and support a model where cell-type-specific repressors actively suppress plasticity throughout life to safeguard lineage identity and thus prevent disease.
Phase equilibria and drug partitioning ability of betaine based aqueous two-phase systems
Authors: Zafarani-Moattar Mohammed Taghi , Shekaari Hemayat , Asadollahi Soheila 
Published: February 2025

Abstract
The aqueous two-phase system (ATPS) as an environmentally friendly technique has a high potential for extraction of drugs, proteins, metals, etc. In this work first the formation of ATPSs by betaine, which is a novel, low toxic, and high biodegradable material, and polyethylene glycol or phosphate salts (K3PO4 and K2HPO4) were investigated temperatures of 298.15, 308.15, 318.15 K and atmospheric pressure (≈ 85 kPa). The effect of increasing temperature on the binodal curves was investigated. The experimental binodal data were correlated using two empirical nonlinear three parameter expressions developed by Merchuk, and Zafarani-Moattar et al. and the two-parameter modified equation derived from effective excluded volume theory. Then, the experimental tie-line data were represented with Othmer-Tobias and Setschenow correlations. Finally, in these ATPSs the partition behavior of analgesic drugs, namely acetaminophen, salicylic acid, and ceftriaxone were investigated by measuring of partition coefficient and extraction efficiency. The trend of obtained results showed that the selected drugs were successfully extracted into the top phase of studied ATPSs with a partition coefficient greater than one and in the salt systems extraction efficiency was obtained up to 98% and in the case of polymer systems was obtained up to 8% at different tie-lines and it was found that the hydrophobicity of partitioned drugs is responsible for this phenomenon.
City-scale residential energy consumption prediction with a multimodal approach
Authors: Sheng Yulan , Arbabi Hadi , Ward Wil O. C. , Álvarez Mauricio A. , Mayfield Martin 
Published: February 2025

Abstract
The key role of buildings in tackling climate change has gained global recognition. To avoid unnecessary costs and time wasted, it is important to understand the conditions and energy usage for existing housing stock to identify the most important features affecting energy consumption and to guide the relevant retrofit measures. This paper investigated how the spatial, morphological and thermal characteristics of residential houses contribute to housing energy consumption. Additionally, it presents a rapid assessment tool using minimum data input to answer two main questions: 1) What type of properties may need retrofit? 2) What building elements/features may be prioritised to be retrofitted? A case study was performed with around 143,000 residential properties in Sheffield. An automated machine approach was applied which successfully estimated the energy consumption of target buildings with an
$$R^2$$
score of 0.828. Permutation feature importance and partial dependence of the features were examined against energy consumption. The results indicate that housing sizes and conditions of the external walls are found to be the most important features when estimating the energy consumption of residential buildings in Sheffield. Relatively larger and older detached houses in neighbourhoods with higher build density may benefit the most from home upgrading projects for energy consumption reduction.
Improving case fatality ratio estimates in ongoing pandemics through case-to-death time distribution analysis
Authors: Farooq Zia , Sjödin Henrik , Rocklöv Joacim , Brännström Åke 
Published: February 2025

Abstract
The case fatality ratio (CFR) is a vital metric for assessing the disease severity of novel pathogens. The widely used direct method of CFR estimation—the ratio of total confirmed deaths to total confirmed cases—is inherently simplistic, as it fails to account for the essential time lag between case confirmation to death, and reporting delays. These limitations often lead to biased CFR estimates, particularly in the early stages of outbreaks. This study introduces a novel approach—the distributed-delay method that, like the direct method, utilizes publicly available aggregate time-series data on cases and deaths. It estimates CFR by flexibly incorporating a case-to-death time distribution without requiring a priori assumptions on distribution parameters. Using a fitting approach to forecast case fatalities based on known or assumed case-to-death time distributions, the method consistently recovers true CFR much earlier than the direct method under various simulation settings. These settings reflect variability in disease severity, uncertainties in case-to-death time parameters, and limited knowledge of case-to-death time distributions. It outperforms other methods such as Baud’s, which assumes a non-zero constant case-to-death time, and the Generalized Baud’s method, which allows for a direct comparison with our new approach. While evaluations based on empirical data are challenging, our conclusions are supported by CFR estimates obtained using empirical COVID-19 data from 34 countries. As an added value, this analysis also demonstrates a significant negative association between eventual CFR and the expected case-to-death time within the context of COVID-19 data. Our study highlights the complexities of inferring real-time CFR from aggregate time-series case and death data, highlighting that refining this method can lead to accurate real-time CFR estimations for actual outbreaks.