bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of fractal shaped antenna with MBBA LC material dispersed with ZnO nanoparticles for bandwidth improvement
Authors: Prasad Nagandla , Pardhasaradhi Pokkunuri , Taraka Phani Madhav Boddapati , Venkata Ganesh Gorla , Sidda Reddy Velichalamala , Rama Krishna Nanchara Rao Manepalli , Krishna Mohan Nutakki 
Published: May 2024

Abstract
This article proposes a compact coplanar waveguide (CPW)-fed antenna to improve proposed antenna’s bandwidth without altering its basic design. The proposed fractal shaped antenna comprises a CPW feed with a defective ground structure (DGS). The proposed antenna is operating at single frequency band (C), when the gap between two glass plates is filled with an air and covers two different frequency bands (S and C), when there is a LC material p-methoxy-benzylidene-p-n-butyl aniline (MBBA) with ZnO nanoparticles, further the proposed fractal antenna, resonating from 4.4 to 6 GHz frequency and offers 5.64 dBi peak gain with air gap and operates from 3.1 GHz to 6.8 GHz with a maximum obtained peak gain of 3.9 dBi when filled with MBBA dispersed with ZnO nano particles. IT also evident that the transition temperatures of pure MBBA are reduced when doped with ZnO nano particles. The results are compared and analyzed with the body of data available.
Salvage Reconstruction of a 12-cm Tendon Defect Following Chronic Achilles Rerupture—15-Year Follow-Up
Authors: Manz Wesley J. , Bowman Jason , Pongastron Tee , Sherwood Scot , Labib Sameh A. 
Published: May 2024

Case:
A 39-year-old man with a chronic Achilles rupture status post (1) failed primary repair and (2) secondary xenograft repair with graft rejection, resulting in a 12-cm Achilles tendon defect, which was reconstructed utilizing an Achilles bone block allograft and flexor hallucis longus (FHL) tendon transfer. At 15-year follow-up, the patient reported good functionality and satisfaction with the repair, with positive patient-reported outcome measures. Physical examination revealed excellent strength and range of motion. Magnetic resonance imaging confirmed the integrity and incorporation of the Achilles/FHL graft composite.

Conclusion:
This case study provides valuable insight into successful long-term management of complex chronic Achilles ruptures with large defects.
Mеsozoic Tectonothermal Evolution of the Zagan Metamorphic Core Complex in Western Transbaikalia: 40Ar/39Ar and FTA Dating
Authors: Buslov Mikhail M. , Kulikova Anna V. , Sklyarov Evgenii V. , Travin Alexei V. 
Published: May 2024

Abstract
A model of tectonothermal evolution of the Zagan metamorphic core complex (MCC) based on the new data from 40Ar/39Ar dating of amphibole, mica, and apatite fission-track dating is discussed. A relationship with the long-range impact of processes from the collision of the North China (Amurian–North China) block with the Siberian continent in the Mesozoic era is proposed. The Zagan MСС was formed in the Cretaceous period on the southern flank of a high mountain uplift of Western Transbaikalia, composed of late Paleozoic granitoids of the Angara–Vitim batholith. According to 40Ar/39Ar dating of amphiboles and micas from the mylonite zone, the active development time of the Zagan MCC corresponds to the early Cretaceous epoch (131, 114 Ma). The tectonic exposure of the core from about 15 km to the depths of about 10 km occurred at a rate of tectonic erosion of 0.4–0.3 mm/year as a result of post-collisional extension of the Mongol–Okhotsk orogen. Apatite fission-track dating shows that further exhumation and cooling of the rocks to about 3 km occurred in the lower-upper Cretaceous epoch (112, 87 Ma). The erosional denudation rate was about 0.3 mm/year.MCC- metamorphic core complexes, AFT- apatite fission-track
Optimal Inversion Method Based on Joint Waveform Inversion and Least Squares Reverse Time Migration
Authors: Zhang Kai , Xu Yipeng , Li Zhenchun , He Zilin , Pan Yiming 
Published: May 2024

Abstract
Joint Waveform inversion (JWI) uses the results of reflection waveform inversion (RWI) as the initial model for full waveform inversion (FWI). Compared with the FWI, the JWI method can obtain more information about the structure of the subsurface medium. The reason is that the reflected waveform inversion can invert the long wavelength component in the middle and deep areas. In JWI, reflected waveform inversion is used to obtain the reflected wave information in the simulation record by demigration, which is computationally more expensive than FWI; the least squares reverse time migration (LSRTM) also obtains the reflected wave information in the simulated record by demigration. In order to effectively use the reflected wave information brought by the high computational amount of reverse migration in JWI, this paper proposes a simultaneous inversion method of JWI and LSRTM (JWI-LSRTM). This method can simultaneously perform an iterative update of the subsurface medium velocity of JWI and the migration imaging of LSRTM, which improves the calculation data utilization rate of each forward and inversion process. In the model test, the effectiveness of the method is proved.
Posters of Watching Eyes and Nature Promote and posters of Injunctive Norms Undermine Clean Environments
Authors: Gangl Katharina , Walter Anna , Lange Paul A. M. Van 
Published: May 2024

Abstract

Fostering pro-environmental behavior is central to mitigate climate change. In the present paper four distinct interventions are tested which, based on different processes, should reduce littering: monetary information, depiction of the injunctive norm, watching eyes and a nature picture. To test these interventions, a randomized controlled trial (RCT) involving 440 community building’s waste disposal areas (N = 71,155) was conducted in Vienna. Littering was assessed before the intervention, 24 to 48 hours after and again seven weeks after the intervention. Results show that the financial intervention (monetary information) hardly had any effect on littering whereas the norm-based intervention (depicted injunctive norm) led to more littering compared to the control condition. In contrast, the reputation-based intervention (watching eyes) and ecological-based intervention (nature picture) reduced littering over time. Thus, modern interventions based on soft appeals to reputational and ecological motivations are more effective in fostering clean environments than classical interventions applying information on finances and norms.
Standardization of human-induced pluripotent stem cells by optimizing culture conditions and monitoring key parameters
Authors: Yamamoto Takako , Hosoya Masaki , Kawamata Shin 
Published: May 2024

Abstract

The differentiation potential of human-induced pluripotent stem cells (hiPSCs) is not constant among clones, therefore standardization of iPSCs as a starting material is a key issue for the dissemination of hiPSC-based cell therapy. We showed that hiPSCs cultured with medium that supported the glycolytic pathway demonstrated a high level of chromodomain-helicase-DNA-binding protein 7 (CHD7) expression and retained differentiation potential. Notably, hiPSCs cultured with medium that supported mitochondrial activity expressed a low level of CHD7 and lost differentiation potential. In addition, we showed secretion of kynurenine by undifferentiated hiPSCs, and 2-AAA when differentiated. Thus, we propose re-cloning iPSC clones with medium supporting the glycolytic pathway for standardization, and measuring the expression of CHD7 by flow cytometry to check the differentiation potential and measuring Kynurenine and 2-AAA levels in the culture medium to monitor and assure the differentiation status of cells during culture.
Primary Cutaneous Mucinous Carcinoma: A Case with Diagnostic Dilemma
Authors: Yusof Mohd Rizal Mohd , Hanipah Zubaidah Nor , Nasir Noor Ain Mohd , Gopal Navarasi S Raja , Bahari Norafida , Shaker Abd 
Published: May 2024

Abstract

Introduction: Primary cutaneous mucinous carcinoma (PCMC) is a rare slow-growing neoplasm of the skin with an indolent behaviour. PCMC is slightly more common in men than women and typically affects people at 50 to 70 years old. The usual clinical presentation of PCMC in adults is asymptomatic, solitary erythematous nodule, papule, or cyst of variable sizes typically occurring on the face, scalp or in the axilla. Histologically, PCMC is indistinguishable from metastatic mucinous adenocarcinoma of breasts, gastrointestinal tracts, lungs, and salivary glands. This case report presents a case of PCMC, mimicking a skin metastasis from a male breast cancer. Case Presentation: A 43-year-old Indian gentleman presented with large matted left axillary lymph nodes. Clinical examination showed a wart-like skin lesion (2x2 cm) at the medial aspect of the left axillary region, with multiple matted enlarged left axillary lymph nodes. No abnormalities on bilateral breast examination. He then underwent wide local excision of the skin lesion and excision of the matted left axillary lymph nodes. The axillary skin lesion showed adenocarcinoma with mucinous differentiation and the excised lymph nodes confirmed metastatic mucinous adenocarcinoma. The immunohistochemistry (IHC) of the tumour was positive for mammaglobin, oestrogen receptor (ER), progesterone receptor (PR) and GATA-3. Hence, the initial diagnosis of metastatic primary breast carcinoma was favoured; despite no breast tissue was identified histologically from the axillary specimen. Given this diagnostic dilemma, the slides were sent for a second opinion to the histopathology experts. After further evaluation and multidisciplinary team discussion, the final diagnosis for him was PCMC. Conclusion: PCMC is a rare tumour with challenging clinical presentation and histological diagnostic dilemma. Therefore, a multidisciplinary team approach with strong clinical and radiological correlation is warranted to differentiate PCMC from a case of metastatic breast carcinoma, as the IHC may overlap.
Over-expression of KRT8 is associated with invasion of non-functioning pituitary adenomas
Authors: Chen Yong , Li QingXiu , Song XuRi , Jiang Yu , Liu Bo , Li Zhen , Liu Zhongmei 
Published: May 2024

Abstract

Objectives
This study aimed to investigate the correlation between KRT8 and non-functioning pituitary adenomas (NFPAs).
Methods
Tumor tissues from fifty NFPAs (comprising twenty-nine cases of invasive NFPAs and twenty-one cases of noninvasive NFPAs) obtained from transsphenoidal surgery were utilized. Gene expression levels and protein expression levels were assessed using qRT-PCR and western blot techniques in both invasive and non-invasive NFPAs tumor tissue samples. The level of KRT8 was downregulated in the pituitary adenoma cell line GH3 to examine the invasive effect of KRT8 on GH3 cells using RNA interference.
Results
Both gene and protein expression levels of KRT8 were significantly higher in invasive NFPAs compared to non-invasive NFPAs. In vitro experiments demonstrated a noticeable decrease in cell invasion ability after silencing KRT8.
Conclusion
KRT8 may serve as a crucial biomarker for invasiveness in NFPAs, offering promising guidance for therapeutic decision-making.
Effects of Lactobacillus salivary on spleen T cells and inflammatory factors in a rat model of type II collagen induced arthritis Running title: Effects exploration of Lactobacillus salivary
Authors: Yuan Fei , Huang Nuanqin , Xiao Yunjian , Li Li , Yang Caihong , Yang Min 
Published: May 2024

Abstract

To explore the therapeutic effect and role of Lactobacillus salivarius on rheumatoid arthritis. A Collagen induced arthritis (CIA) model was constructed in male Sprague Dawley (SD) rats by adopting bovine type II collagen as immunogen. The modeled rats (24 SD rats) were randomly divided into the CIA model group, salivary lactobacillus group, and methotrexate group, and 8 rats in each group with healthy group. Both the healthy group and CIA group were administered bacterial culture medium; the salivary lactobacillus group administered salivary lactobacillus. The methotrexate group given methotrexate medication, and each group was continuously operated by gavage for 4 weeks. After that, evaluated arthritis index, thickness of the affected foot, pathological changes in the naked joint tissue, and histopathological staining. Moreover, the content of T helper cell 17 (Th17) and regulatory T cells (Treg) in the spleen were also detected, and included the levels of expression of interleukin-1 β (IL-1 β), Interleukin-10 (IL-10), Interleukin-17 (IL-17), Interleukin-2 (IL-2), Interleukin-6 (IL-6), Interleukin-8 (IL-8), γ Interferon (IFN- γ), and Tumor Necrosis Factor- α (TNF- α) in the serum of each group. Compared with the CIA model group, the arthritis index score, onset foot thickness, spleen Th17 cells, the content of inflammatory factors above were significantly decreased (P < 0.05) in the salivary lactobacillus group and methotrexate group. The level of Th17 cells significantly increased (F-value: 238.918, P < 0.05), and the content of Treg cells significantly increased (CIA group: 9.47 ± 0.30, Salivary Lactobacillus group: 13.04 ± 0.47, Methotrexate group: 22.41 ± 0.33, P = 0.003 < 0.05); while the Th17/Treg cell ratio in both the salivary lactobacillus group and the methotrexate group was decreased (CIA group: 0.62 ± 0.03, salivary lactobacillus group: 0.29 ± 0.11, methotrexate group: 0.15 ± 0.03, P = 0.004 < 0.05). However, there was no significant difference in the content of spleen Th17 cells, Th17/Treg ratio, and total joint pathology score (P = 0.54 > 0.05) between the salivary lactobacillus group and the methotrexate group. Lactobacillus salivarius has immune regulatory and anti-inflammatory effects on CIA model SD rats, and the corresponding mechanism of action is mainly reflected in the regulation of Th17 and Treg cell balance, and inhibiting the expression of inflammatory factors.
Construction and Validation of a Risk Prediction Nomogram Model for Different Sites of Ankle Pain in Patients with Chronic Ankle Instability Using the OpenSim Environment
Authors: Zhang Zeyi , Song Jian , Shi Hanlin , Wei Shengmeng , Sun Youping 
Published: May 2024

Abstract

This study aimed to establish a risk prediction nomogram model for anterolateral, mediolateral, and posterolateral ankle pain in patients with chronic ankle instability (CAI) and analyse the risk factors for pain at different ankle sites. Thirty runners with CAI who reported ankle pain in the anterolateral, mediolateral, or posterolateral regions were recruited for this study. Kinematic, kinetic, and electromyographic data during running were collected using motion capture system, etc. These data were used to generate a dynamic nomogram. The results showed that anterolateral ankle pain in patients with CAI may be caused by insufficient gastrocnemius muscle strength (OR = 0.85, 95% CI: 0.73 ~ 0.97), excessive ground reaction force (GRF, OR = 2.64, 95% CI: 1.25 ~ 6.22), and an increased percentage of ankle energy absorption (OR = 9.11, 95% CI: 1.50 ~ 77.79). Mediolateral ankle pain might be contributed by greater ankle inversion angle (OR = 1.08, 95% CI: 1.01 ~ 1.00) and GRF (OR = 2.13, 95%CI: 1.17 ~ 4.31). Moreover, posterolateral ankle pain was predicted by increased ankle internal rotation angle (OR = 1.06, 95% CI: 1.00-1.12), increased GRF (OR = 2.16, 95% CI: 1.07–4.80), and decreased dynamic stability (OR = 0.20, 95% CI: 0.05–0.68). To prevent ankle pain, patients with CAI should be encouraged to focus on improving the neuroreceptor sensitivity of the gastrocnemius muscles, and retraining their energy absorption patterns.
Is It Worth Performing Inter-Sphincteric Resection in Patients Having Rectal Adenocarcinoma with Oligo-Metastasis: A Study Of 416 Patients.
Authors: Kaderi Abdeali Saif Arif , Singh Sanjay , Sharma Ankit , Kazi Mufaddal , Desouza Ashwin , Saklani Avanish 
Published: May 2024

Abstract

Purpose:
Inter-sphincteric resection (ISR) is being increasingly performed in metastatic rectal adenocarcinoma (with oligo-metastasis) patients. There has been a trend towards worse prognosis in this group. This study compares the oncological and surgical outcomes of patients with and without pre-operative oligo-metastasis who underwent ISR. The outcomes compared include prognostic factors like margin positivity, recurrence rates, stoma reversal rate, surgical failure rate (defined as a combination of one or more of the aforestated factors). The demographic pattern, American Society of anaesthesia grade (ASA), treatment received, clinical and histopathological T and N stage, grade, type of MIS approach, neoadjuvant therapy and pathological high-risk features are also studied.
Methods:
Patients who underwent minimally invasive ISR over ten years at a high-volume tertiary cancer centre were selected for the study. Factors used for the assessment of oncological outcomes were margin positivity (circumferential resection and distal margin), recurrence (both local and systemic) and stoma reversal rate. A descriptive and comparative analysis were performed.
Results:
Four hundred and eight patients underwent minimally invasive ISR of which 25 (6.12%) patients were oligo-metastatic. Higher recurrence (24% versus 18.5%) and low stoma reversal rate (36.8% versus 67.3%) were observed in the oligo-metastatic group with statistically significant differences. Though no local recurrence was seen in the oligometastatic group the difference was not statistically different. Margin positivity was the same in both groups.
Conclusion:
This study shows that oligometastatic patients who underwent ISR experienced higher recurrence and low stoma reversal rates without affecting margin positivity.
Preparation of contamination-resistant ultraviolet broadband double-layer antireflective coating
Authors: Wang Wenwen , Jin Zhiyong , Xiao Zhiwei , Jia Hongbao , Zhang Zichao , Yang Chunming , Wang Ying , Wu Henan , Zhu Shihai 
Published: May 2024

Abstract

A double-layer broadband antireflection (AR) coating with excellent transmittance at 250–400 nm has been designed and prepared by the sol-gel method. The quarter-half double-layer structure is optimized with the aid of Filmstar thin film design software. Mesoporous SiO2 film templated by an ethylene oxide-propylene oxide-ethylene oxide triblock copolymer is used as the top layer, and a ZrO2-SiO2 hybrid film with matching refractive index is employed as the bottom layer. 1H, 1H, 2H, 2H-Perfluorodecyltriethoxysilane is used to modify the surface of the AR coating, which greatly improves the environmental stability of the coating. The obtained double-layer AR coating can achieve an average transmittance of 99.34% in the wavelength range of 250–400 nm. The laser induced damage threshold of the coating is measured using a 355 nm laser (pulse width: 6.4 ns), and the results show that the damage threshold is 2.24 J·cm− 2. This study provides a new way for the preparation of UV AR coatings with good optical performance and environmental stability.
A Self-Powered Enzymatic Glucose Sensor Utilizing Bimetallic Nanoparticle Composites Modified Pencil Graphite Electrodes as Cathode
Authors: Emir Gamze , Dilgin Yusuf , Sahin Samet , Akgül Cahit 
Published: May 2024

Abstract

Enzymatic biofuel cells (EBFC) are promising sources of green energy owing to the benefits of using renewable biofuels, eco-friendly biocatalysts, and moderate operating conditions. In this study, a simple and effective EBFC was presented using an enzymatic composite material-based anode and a nonenzymatic bimetallic nanoparticle-based cathode, respectively. The anode was constructed from a glassy carbon electrode (GCE) modified with a multi-walled carbon nanotube (MWCNT) and ferrocene (Fc) as a conductive layer coupled with the enzyme glucose oxidase (GOx) as a sensitive detection layer for glucose. A chitosan layer was also applied to the electrode as a protective layer to complete the composite anode. On the other hand, the cathode consisted of a disposable pencil graphite electrode (PGE) modified with platinum-palladium bimetallic nanoparticles (Nps) which exhibit excellent conductivity and electron transfer rate for the oxygen reduction reaction. The EBFC consisting of MWCNT-Fc-GOx/GCE anode and Pt-PdNps/PGE cathode exhibits an open circuit potential of 285 mV and a maximum power density of 32.25 µW cm− 2 under optimized conditions. The results show that the proposed EBFC is a promising candidate for detecting glucose while harvesting power from artificial serum samples.
Insufficient diffusion of tedizolid in cerebrospinal fluid: about a case report and mini-review of literature
Authors: BROUSSE Xavier , LÊ Minh P , LAHOUATI Marin , PETITGAS Paul 
Published: May 2024

Abstract

Background: Tedizolid, a recent oxazolidinone developed for skin and soft tissues infection with bacteriostatic activity, is believed to have identical pharmacokinetic parameters to linezolid with less myelosuppression and neurotoxicity. However, its neuro-meningeal diffusion seems different than linezolid. This case report and this review aim to investigate the diffusion of this molecule.
Case presentation: We report a clinical case of meningitis secondary to skull base osteomyelitis and we present a rapid review of literature. Liquid chromatography coupled with mass tandem spectrometry was used to measure tedizolid concentration.
The trough concentration in CSF was under the limit of quantification while serum concentration was appropriate. A short review of the literature seems to confirm that meningeal diffusion is weaker than linezolid.
Conclusion: It is therefore important to be cautious when prescribing tedizolid in neuro-meningeal infections, especially if targeted pathogens have high MICs.
KNL1 is a lung cancer prognostic biomarker associated with the immune microenvironment
Authors: Dong YiRan , Wu Ting , Chen Jiayang , Mo Liang , You Yong 
Published: May 2024

Abstract

Background: Kinetochore scaffold 1 (KNL1) plays a crucial role in cell cycle regulation and is implicated in lung adenocarcinoma (LUAD) progression, especially in the tumor microenvironment and immunotherapy. Our study aims to investigate KNL1's potential as a therapeutic target for LUAD.
Methods: We conducted pan-cancer analysis of KNL1 expression using the CancerSea database and performed survival analysis. Functional studies included GO, KEGG, and GESA analyses, as well as protein interaction network construction. Immune infiltration analysis was conducted using six algorithms from the "IOBR" R package. Therapeutic effects of immune checkpoint inhibitors were predicted using the TIDE and TCIA databases, and drug responses were forecasted using the "Oncopredict" R package.
Results: KNL1 was significantly expressed across 22 malignancies, including LUAD, and correlated with worse prognosis. Immune infiltration analysis revealed associations between KNL1 expression and various immune cell types. Higher KNL1 expression was associated with increased susceptibility to CTLA4 inhibitors. Drug prediction suggested potential treatments for LUAD patients with high KNL1 expression.
Conclusion: Our findings suggest KNL1 as a potential therapeutic target for LUAD, particularly in immunotherapy, making it a valuable biomarker for treatment strategies in this cancer type.