bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penerapan Metode Cluster Dalam Data Mining Mengelompokkan Kenakalan Remaja (Studi Kasus Polda Sultra)
Authors: Rival Muhammad , Misriani Misriani , Bakrim La Ode 
Published: May 2024

Masalah sosial perilaku menyimpang kenakalan remaja di wilayah Sulawesi Tenggara sudah banyak terdengar atau bahkan sering membuat masyarakat itu sendiri merasakan dampak yang terjadi akibat kenakalan remaja tersebut. Data Mining yaitu sebuah proses menyatukan dan mengolah data untuk mengekstrak informasi penting. K-Means clustering adalah algoritma unsupervised learning yang dipakai untuk mengelompokkan dataset yang belum dilabel ke dalam kluster yang berbeda. Simbol K pada K-Means clustering menandakan jumlah kluster yang digunakan. Hasil dari penelitian ini dengan wilayah yang terdominasi jumlah kenakalan remaja terbanyak yaitu kota Kendari yang menduduki puncak sebanyak 2588 kasus, Muna 2427 kasus, Baubau 893 kasus, Konawe 786 kasus, Konawe Selatan 776 kasus, Buton 558 kasus, Kolaka 494 kasus, Wakatobi 240 kasus, Kolaka Utara 212 kasus, Bombana 187 kasus, Butur 90 kasus, Konawe Utara 82 kasus, Buton Tengah 14 kasus, dan Kolaka Timur sebanyak 12 kasus kenakalan remaja.
Analisis Pengukuran Kualitas Pelayanan Perbankan pada Aplikasi LIVIN by Mandiri menggunakan framework ITIL V3
Authors: Wulantari Nur Ayu , Tata Sutabri  
Published: May 2024

Penelitian ini membahas tentang analisis manajemen pelayanan perbankan pada aplikasi Livin by Mandiri yang berbasis TI dengan menggunakan framework ITIL 3. Penelitian dilakukan dengan tujuan untuk meningkatkan kualitas layanan perbankan pada aplikasi Livin by Mandiri. Metode yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan teknik pengumpulan data melalui wawancara dan observasi. Hasil penelitian menunjukkan bahwa implementasi framework ITIL3 pada aplikasi Livin by Mandiri dapat meningkatkan manajemen pelayanan perbankan dengan penggunaan ITIL 3 Service Management Lifecycle yang meliputi strategi layanan, desain layanan, transisi layanan, operasi layanan, dan pemantauan layanan. Dengan demikian, penggunaanframework ITIL 3 dapat membantubank dalam mengeloladan meningkatkan kualitas layanan padaaplikasi Livin by Mandiri
The impact of facial pattern on esthetic evaluation of cheek size
Authors: Pizzurno Lucia Gloria Diana Aguilar , Fernandes Thais Freire , Oltramari Paula Pedron , Conti Ana Claudia Ferreira de Castro , Almeida Márcio Rodrigues de , Almeida-Pedrin Renata 
Published: May 2024

This research evaluate the facial esthetic related to cheek size changes in vertical facial patterns. The sample included 18 images of three female models with brachyfacial, mesofacial and dolichofacial patterns. Frontal facial photographs were taken at rest and smiling, and modified simulating bichectomy or cheek augmentation. A total of 76 evaluators were invited, including laypersons (LP) (n=25), professionals with experience in facial harmonization (HOFp) (n=25) and orthodontists (n=26), to judge the attractiveness of the face according to the Likert scale. The Kruskal-Wallis test for the evaluators and the Friedman test for the cheeks changes at a significance level (p<0.05) were used. In the brachyfacial pattern, resting photography with bichectomy simulation was preferred by HOFp and LP. According to LP, there is a tendency to assign higher grades to the brachyfacial smile photo, regardless of the alteration. In the mesofacial pattern, cheek augmentation, original and reduction, at rest and smiling, were similarly evaluated by the 3 groups. In the dolichofacial pattern, LP gave higher scores than orthodontists for all cheek changes in smile photographs. It is concluded that facial esthetic in relation to cheek size in the different vertical facial patterns was assessed differently by orthodontists, HOFp and LP. However, it was not possible to identify a preferred size (original, -6mm or +6mm) for each facial pattern. The clinical relevance of this study is related to the orientation of patients in making decisions about the treatment plan, including aesthetics and multidisciplinarity, considering the facial pattern and the patient's opinion.
Enraizamento de estacas de marula em resposta a aplicação de ácido 3-indolacético e fosfato monoamônico
Authors: Souza Mirna Ariane Taveira de Sousa e , Maia Victor Martins Maia , Santos João Rafael Prudêncio dos , Silva Bruno Soares da , Oliveira Fernanda Soares 
Published: May 2024

A marula (Sclerocarya birrea) é uma espécie de origem africana com importância nutricional e medicinal, com grande potencial de produção nas regiões de clima semiárido. Por se tratar de uma espécie dióica faz-se necessário o uso de propagação vegetativa a fim de se obter plantas com maior uniformidade e vigor, reduzindo o período juvenil e antecipando a floração e produção. Objetivou-se com o presente trabalho avaliar o enraizamento de estacas da maruleira tratadas com diferentes concentrações de fosfato monoamônico (MAP) e ácido indolacético (AIA). Os experimentos foram conduzidos no viveiro de mudas da Universidade Estadual de Montes Claros do campus Janaúba, utilizando estacas semilenhosas de plantas masculinas e femininas. Utilizou-se delineamento inteiramente casualizado, no esquema fatorial 5 x 5, correspondentes as concentrações de AIA (0; 250; 500; 1000 e 2000 mg L-1) e concentrações de MAP (0; 4834,3; 9668,8; 14503,2 e 24172 mg L-1), com 5 repetições. Avaliou-se a porcentagem de estacas vivas, número de ramos ou brotações, comprimento de ramo, diâmetro da base do ramo, número de folhas, porcentagem de estacas enraizadas, matéria fresca e seca de folhas, ramos e raízes; comprimento e volume de raízes. Foi observado média geral de 2,4% de enraizamento e 74,4% de estacas vivas para as estacas da planta feminina e 32,8% de estacas vivas e 0% de estacas enraizadas para as estacas da planta masculina. Não foram encontradas diferenças significativas entre as variáveis enraizamento e estacas vivas, em função das concentrações de AIA e MAP, não havendo promoção do crescimento das mesmas.
Analisis dan Perancangan Sistem Informasi Penyaluran Dana Zakat berbasis Web menggunakan Framework Laravel: Studi Kasus di Yayasan Baitul Maal PLN Depok
Authors: Munir Sirojul , Surya Tubagus Muhammad Billal Zakky 
Published: May 2024

Yayasan Baitul Maal PLN Depok adalah salah satu lembaga amil zakat nasional yang saat ini dalam pengelolaan administrasinya YBM PLN masih menggunakan cara manual yaitu dengan menerima berkas pengajuan dan menentukan waktu agar bisa berdiskusi dengan manajemen YBM PLN barulah diambil keputusan dari hasil diskusi tersebut. Cara tersebut sangat memakan waktu yang lama, karena seorang amil yang menerima berkas pengajuan tersebut harus menunggu waktu senggang dari manajemen YBM PLN tersebut. Dalam membangun sistem ini dilakukan tahapan pengumpulan data dengan studi pustaka dan studi lapangan, Tahapan desain dan pengembangan sistem menggunakan pemodelan diagram Unified Modeling Language dan model pengembangan Extreme Programming. Berdasarkan hasil dari pengujian black box terhadap fungsionalitas aplikasi didapatkan persentase keberhasilan sebesar 100%. Untuk pengujian UAT didapatkan hasil 100% pada sisi super-admin, 100% pada sisi admin, 100% pada sisi amil dan 100% pada sisi pegawai. Sedangkan dari hasil kuesioner yang diberikan kepada 10 responden terkait kelayakan aplikasi, didapatkan hasil sebesar 75%. Kesimpulannya adalah aplikasi penyaluran dana zakat cukup memudahkan YBM PLN dalam memberikan keputusan terhadap pengajuan yang diterima.
ผลของพฤติกรรมการแบ่งปันความรู้ที่มีต่อผลการปฏิบัติงานของพนักงาน โดยมีพฤติกรรมการทำงานเชิงนวัตกรรมเป็นตัวแปรส่งผ่าน
Authors: ทรงทิพย์ สมฤดี , ทวีไพบูลย์วงษ์ จุฑามาศ 
Published: May 2024

การวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาความสัมพันธ์ระหว่างพฤติกรรมการแบ่งปันความรู้ พฤติกรรมการทำงานเชิงนวัตกรรม และผลการปฏิบัติงานของพนักงาน รวมถึงวิเคราะห์บทบาทการเป็นตัวแปรส่งผ่านของพฤติกรรมการทำงานเชิงนวัตกรรมในความสัมพันธ์ระหว่างพฤติกรรมการแบ่งปันความรู้และผลการปฏิบัติงานของพนักงาน กลุ่มตัวอย่างได้แก่พนักงาน บริษัทผู้ผลิตอาหารเสริมแห่งหนึ่ง ในจังหวัดชลบุรี จำนวน 220 คน ใช้แบบสอบถามเป็นเครื่องมือในการเก็บข้อมูล โดยการสุ่มตัวอย่างแบบแบ่งชั้นตามสัดส่วน การทดสอบสมมติฐานการวิจัยใช้การวิเคราะห์โมเดลสมการโครงสร้าง ผลการศึกษาพบว่า โมเดลการวัดมีความเที่ยงและความตรง และโมเดลโครงสร้างความสัมพันธ์ระหว่างพฤติกรรมการแบ่งปันความรู้ พฤติกรรมการทำงานเชิงนวัตกรรม และผลการปฏิบัติงานของพนักงานมีความสอดคล้องกับข้อมูลเชิงประจักษ์ โดยมีค่า CMIN/DF = 1.657, GFI = 0.962, AGFI = 0.923, TLI = 0.984, CFI = 0.990, NFI = 0.976, RMR = 0.014, RMSEA = 0.055 การวิเคราะห์เส้นทางอิทธิพลพบว่าพฤติกรรมการแบ่งปันความรู้ส่งผลทางบวกต่อผลการปฏิบัติงานของพนักงาน พฤติกรรมแบ่งปันความรู้ส่งผลทางบวกต่อพฤติกรรมการทำงานเชิงนวัตกรรมของพนักงาน และพฤติกรรมการทำงานเชิงนวัตกรรมส่งผลทางบวกต่อผลการปฏิบัติงานของพนักงานอย่างมีนัยสำคัญทางสถิติ และจากการทดสอบการเป็นตัวแปรส่งผ่านของพฤติกรรมการทำงานเชิงนวัตกรรม พบว่า พฤติกรรมการทำงานเชิงนวัตกรรมของพนักงานเป็นตัวแปรส่งผ่านแบบบางส่วนระหว่างความสัมพันธ์ของพฤติกรรมการแบ่งปันความรู้และผลการปฏิบัติงานของพนักงาน โดยความแปรปรวนของพฤติกรรมแบ่งปันความรู้และพฤติกรรมการทำงานเชิงนวัตกรรมสามารถอธิบายความแปรปรวนของผลการปฏิบัติงานของพนักงานได้ร้อยละ 41
Enhancing Oral Solubility and Permeability of Edoxaban Tosylate Via Development of Self-microemulsifying Drug Delivery System
Authors: Azad Syeda Aneela , Ilyas Umair , Altaf Reem , Saleem Kalsoom , Gul Shaista 
Published: May 2024

Edoxaban tosylate monohydrate (EDTM) is present in class IV of the biopharmaceutics classification system (BCS), as it is poorly soluble and poorly permeable, which limits its bioavailability. The rationale of this study was to improve the permeability and solubility of EDTM by incorporating it into a self-micro-emulsifying drug delivery system (SMEDDS). Suitable excipients were selected and evaluated for their compatibility. The solubility of EDTM was evaluated for all excipients (oil, surfactant, and co-surfactants) at different ratios. Olive oil, Kolliphor RH40, and PEG-400 were chosen as the oil, surfactant, and co-surfactants, respectively, and were developed into a SMEDDS by adding 15 mg of EDTM. The optimized EDTM-SMEDDS (F1, F2, F3, and F4) were characterized for particle size, polydispersity index (PDI), zeta potential, stability, in vitro release, and ex vivo permeation studies. F2 showed a particle size of 56.43 ± 1.78, PDI of 0.190 and -3.30 ± 0.56 mV of zeta-potential. The enhanced release and permeability of F2 were observed for all other EDTM-SMEDDSs and raw EDTM dispersions. Upon storage under continuous temperature and accelerated stability conditions, F2 showed no signs of phase separation and was visually clear while retaining the %encapsulation efficiency and drug loading, that is, it was stable. The liquid EDTM-SMEDDS improved the bioavailability of EDTM.
Genetic Polymorphisms in GABRD and Treatment Response and Dose in Methadone Maintenance Treatment
Authors: Editorial Staff  
Published: May 2024

Xie and colleagues studied the association between the genetic polymorphs of the GABA receptor delta subunit (GABARD) and dose-response to methadone in heroin addicts subjected to methadone maintenance therapy (MMT) was studied. They investigated two groups: responders and non-responders were created from a total of 286 recruited MMT patients where the parameter for classification was retention time in therapy. According to stabilized methadone dose, 177 patients were divided into subgroups of high dose and low dose. TaqMan SNP assay was used for GABRD genotyping and the following single nucleotide polymorphisms (SNPs) were identified rs2376805 rs13303344, rs2229110, and rs4481796. MMT treatment response and dose showed no significant association with the SNPs whereas the ACGC haplotype for the 4 SNPs varied slightly between the non-responder and responder groups. They concluded that genetic polymorphs of the GABARD do not play a major role in effecting treatment response to methadone Per Med. 2021 Sep;18(5):423-430.
Novel Genetic Variants Associated With Cardiovascular Events in Clopidogrel and Aspirin Users
Authors: Editorial Staff  
Published: May 2024

Despite reports showing the effects of genetic variations on major adverse cardiovascular events in individuals suffering from acute coronary syndrome (ACS) and in patients undergoing percutaneous coronary intervention (PCI), the data, studied until now, covers only a minute fraction of the genetic variations of the human genome. Using two-stage large-scale sequencing data which consists of high-depth exome sequencing of 168 patients in the discovery cohort and 1793 patients of the replication cohort being subjected to high-depth targeted sequencing, Lie and colleagues discovered novel variants that show associations with major cardiovascular events in a 1.5 year-long follow-up. MYOM2 (rs17064642), ECHS1 (rs140410716), AGAP3 (rs75750968), WDR24 (rs11640115), EFR3A (rs4736529), NECAB1 (rs74569896), ZDHHC3 (rs3749187), and KRTAP10-4 (rs201441480) were the 8 novel genotypes that we found to bear associations with major cardiovascular adverse effects in patients with ACS. MYOM2 and ECHS1, interestingly, were downregulated both in human and animal models with adverse effect-related phenotypes. With AUC ranges between 0.92 and 0.94 for three machine-learning methods, Liu and colleagues were able to develop a superior classifier for predicting these adverse events over a period of 18 months. Their findings bring focus to predicting cardiovascular adverse outcomes and can aid clinicians in optimizing pharmacological intervention while treating patients suffering from ACS. Pharmacogenomics J. 2021 Dec;21(6):664-672.
MTHFR Gene Polymorphisms and Response to Chemotherapy in Metastatic Colorectal Cancer
Authors: Editorial Staff  
Published: May 2024

Ramos-Esquivel and colleagues investigated the association between the first-line fluoropyrimidine-based chemotherapy being administered to patients diagnosed with metastatic colorectal adenocarcinoma and C677T, A1298C single nucleotide polymorphisms (SNPs) of the enzyme methylenetetrahydrofolate reductase (MTHFR). Between January 2019 and November 2020, 68 individuals admitted to San Juan de Dios Hospital in Jose, Costa Rica were subjected to a prospective follow-up. Capecitabine/5-fluorouracil was co-administered with oxaliplatin/irinotecan. Their findings reveal that patients that were homozygotes for the wild-type allele demonstrated a poorer overall response rate as compared to those that possessed one or both MTHFR677T T alleles. MTHFR A1298C genotypes and overall response exhibited no association. Patients with progression-free survival did not contain the MTHFR 677 TT and CT genotypes compared to CC individuals. These conclusions continued to hold post adjustment of confounding factors. A hazard ratio: 1.35; 95% CI, 0.72–2.55; P = 0.34 showed no association between progression-free survival and the MTHFR A1298C SNP. Moreover, no SNP was associated with overall survival. The authors conclude that MTHFR C677T SNP homozygotes and heterozygotes had a better overall response and longer progression-free survival than patients that were homozygous for the wildtype allele. Pharmacogenet Genomics. 2021 Dec 1;31(9):191-199.
Genetic Variations and Drug-Induced Liver Injury in Patients on Simvastatin
Authors: Riaz Muhammad Naeem , Salar Rehan Ullah , Rehman Halim Ur , Noor Sadia 
Published: May 2024

Drug-induced liver injury, or DILI, is a primary reason for heart failure. Uridine diphosphate glucuronosyltransferase 1-1 encoded by the UDP glucuronosyltransferase family 1-member A1 gene (UGT1A1) helps prevent DILI by taking part in reactions that conjugate glucuronic acid with bilirubin. UGT1A1 variations are reported to be linked with DILI. In this study, we investigated the association between genetic variations in UGT1A1 and hepatic adverse effects in patients treated with simvastatin. Our results show that rs4148325 is not significantly associated with elevated bilirubin levels. Therefore, our study suggests that genotypic variations in the UGT1A1 gene may be responsible for simvastatin-related increases in bilirubin levels in our patient cohort. We conclude that genotyping patients on simvastatin for variations in the UGT1A1 gene may not help predict whether these patients are more likely to suffer from liver injury and consequently can change the drug or dose of the drug.
Resistance of Breast Cancer Cells to Paclitaxel Elucidated
Authors: Editorial Staff  
Published: May 2024

The effects of the gene SHOC2 in breast cancer patients and how it is regulated by the long noncoding RNA (lncRNA) MALAT1 were studied to elucidate the potential resistance mechanism to chemotherapy. Breast cancer cells were conferred resistance to Paclitaxel via titrating the cells with increasing doses of the drug. For predicting MALAT1 miRNA regulation, bioinformatic tools were used. It was observed that Paclitaxel resistance in the breast cancer cells was liked to an elevated expression of SHOC2 and MALAT1. They found that MALAT1 confers the Paclitaxel resistance by sequestering miR-497-5p to exaggerate the expression of SHOC1. Increased expression of SHOC2 and MALAT1 in breast cancer has demonstrated poorer therapeutic outcomes of Paclitaxel. They concluded that inhibition of MALAT1 and SHOC2 will lead to up-regulation of miR-497-5p, improving response to Paclitaxel in breast cancer patients. Pharmacogenomics. (2022) DOI: 10.2217/pgs-2022-0077.
Pregnane X Receptor Gene Variation and Total Mortality in Nonalcoholic Fatty Liver Disease
Authors: Staff Editorial 
Published: May 2024

The pregnane X receptor (PXR) is a nuclear receptor that plays a role in regulating the metabolism and clearance of drugs and xenobiotics in the liver. Variations in the PXR gene, including the rs7643645 variant, have been associated with altered PXR activity and potential implications for various liver-related conditions, including nonalcoholic fatty liver disease (NAFLD). It is known that the more progressive the NAFLD, the higher the hepatic and extra-hepatic mortality and morbidity. Käräjämäki et al investigated the total mortality in Finnish middle-aged ultrasonographically verified NAFLD patients with PXR rs7643645 variants. In up to 30 years of follow-up, PXR rs7643645 GG subjects were at an increased risk of total mortality compared with AA/AG subjects. The statistically significant difference prevailed after multiple adjustments for potentially confounding factors, RR, 2.024 (1.191-3.440), P = 0.009. In the subjects without NAFLD, the mortality risk was not associated with rs7643645 variants, 1.051 (0.708-1.560; P = 0.804). As the rs7643645 G variant disrupts a putative hepatocyte nuclear factor 4α binding site located in the PXR gene promoter and is associated with lower hepatic expression of PXR and its target genes, their result suggests that genetic disruption of xenobiotic metabolism increases mortality in subjects with NAFLD. Pharmacogenet Genomics. 2023 Feb 1;33(2):35-39. doi: 10.1097/FPC.0000000000000489.
Editor's Summaries of the Articles Published in This Issue of Precision Medicine Communications
Authors: Staff Editorial 
Published: May 2024

In this issue, Rafiq et al, investigated noncancerous FDA-approved drugs for repurposing through molecular docking studies in Breast Cancer patients after their target cystic fibrosis transmembrane conductance regulator protein (CFTR) detection in breast cancer patients. Konain and colleagues evaluate the anticancer potential of commonly used angiotensin receptor blocker (ARB) telmisartan and validate it through molecular techniques, Bangash and friends investigate whether the efficacy and adverse effects of fluvoxamine are associated with polymorphism in the CYP2D6 gene in patients with depression; Mubarak and colleagues reviewed studies aimed at investigating resistance to Carbamazepine in epilepsy patients influenced by the polymorphism of genes encoding metabolic enzymes and drug transporters, while Riaz and Chen provide general information about Type 2diabetes mellitus, treatment challenges, and pharmacogenetic aspects of metformin pharmacotherapy in type 2 diabetes mellitus.
TREX1 Mutations in Aicardi–Goutières Syndrome with Congenital Glaucoma
Authors: Staff Editorial 
Published: May 2024

Aicardi–Goutières syndrome (AGS) is a rare genetic disorder that primarily affects the brain, the skin, and the immune system. It is characterized by a group of symptoms that mimic the effects of a viral infection, leading to inflammation in various tissues. Świerczyńska and colleagues presented a case of a neonate with hypotrophy, microcephaly, frostbite-like skin lesions, thrombocytopenia, elevated liver enzymes, and hepatosplenomegaly and showed that she had ‘three prime repair exonuclease 1’ (TREX1) gene mutations. The genetic investigation found pathogenic mutations, c.490C>T and c.222del (novel mutation) in the TREX1 gene showing AGS type 1 (AGS1). High serum IFN-α levels were also found. Later examination showed multiple ocular abnormalities including intraocular pressure (IOP) of 51 mmHg in the right eye and 49 in the left eye. The patient was diagnosed with congenital glaucoma, and it was managed with trabeculectomy with a basal iridectomy of both eyes, resulting in a reduction and stabilization in the IOP to 12 mmHg in the right eye and 10 mmHg in the left eye without any hypotensive eyedrops. This case report adds to the growing evidence of the involvement of the pathogenic c.490C>T and c.222del mutations in TREX1 in ophthalmic abnormalities. J Pers Med. 2023 Nov 15;13(11):1609. doi: 10.3390/jpm13111609.