bluuebunny/crossref_metadata_2025_split huggingface dataset:
Una revisión de literatura sobre el mercado de Bonos de Carbono
Authors: Plaza Calle Erika Liliana , Tonon Ordóñez Luis Bernardo , Cevallos Rodríguez Estefanía 
Published: May 2024

El desarrollo y la producción industrial, han requerido un alto uso de combustibles fósiles lo que ha conllevado a un deterioro ambiental, en el contexto del cambio climático y gracias al Protocolo de Kioto, se creó el mercado de carbono como mecanismo de la economía verde. Mediante el método PRISMA se realizó una revisión descriptiva de literatura desde 2007 hasta el año 2022 para conocer cómo se desarrolló el mercado de bonos de carbono. En un primer momento, estos instrumentos financieros negociados en mercados internacionales facilitaron a países desarrollados el cumplimiento de los compromisos de reducción de emisiones, así como la financiación de proyectos limpios en países en desarrollo, sin embargo, su demanda disminuyó en 2013 bajo la crítica de si tenían verdadero compromiso ambiental o se estaba beneficiando a las grandes industrias para que puedan contaminar más. Finalmente, estos documentos fueron sustituidos por la negociación de bonos verdes al ser más flexibles. Palabras Clave: cambio climático, deterioro ambiental, dióxido de carbono, mercado financiero
Abstract
Industrial development and production have required a high use of fossil fuels, which has led to environmental deterioration. In thecontext of climate change and thanks to the Kyoto Protocol, the carbon market was created as a mechanism of the green economy. Using the PRISMA method, a descriptive literature review was carried out from 2007 to the year 2022 to learn how the carbon credit market developed. At first, these financial instruments negotiated in international markets facilitated developed countries to comply with emission reduction commitments, as well as the financing of clean projects in developing countries, however, their demand decreased in 2013 under the criticism of whether they had true environmental commitment or were benefiting large industriesso that they could pollute more. Eventually, these documents were replaced by the trading of green bonds because they were more flexible.Keywords: climate change, carbon dioxide, environmental degradation, financial markets
Pengaruh Kegiatan Senam Irama Terhadap Kemampuan Kinestetik Anak Usia Dini Kelompok B Di TK PGRI Tanjung Batu Ogan Ilir
Authors: Putri Salsabila , Cindrya Elsa , Laila Nur 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Kegiatan Senam Irama Terhadap Kemampuan Kinestetik Anak Usia Dini Kelompok B di TK PGRI Tanjung Batu, Kecamatan Tanjung Batu, Kabupaten Ogan Ilir. Metode penelitian ini adalah Metode Eksperimen. Metode eksperimen ini adalah metode yang mencari pengaruh terhadap sesuatu antara sebab dan akibat yang dilakukan oleh peneliti. Penelitian ini menggunakan jenis Pre Eksperimental Designs dengan design One Group Pretest-Posttes Designs. Populasi penelitian ini adalah anak-anak kelompok B yang berjumlah 14 anak di TK PGRI Tanjung Batu. Observasi dilakukan penulis bertujuan untuk mengetahui Pengaruh kegiatan senam irama terhadap kemampuan kinestetik anak usia dini kelompok B. Belrdasarkan hasil penelitian dan hasil analisis data yang dilakukan peneliti di TK PGRI Tanjung Batu, Kecamatan Tanjung Batu Kabupaten Ogan Ilir, dengan subjek penelitian 14 peserta didik yang dimana tidak telrdapat pengaruh yang signifikan antara kegiatan senam irama terhadap kemampuan kinestetik anak pada kelompok B, yang diperoleh thitung = 5,806 sedangkan dk = 14-1=13 dengan taraf 5% sehingga didapat ttabell = 1,245 karena thitung ttabel (5,8061,245). Maka Ho diterima dan Ha ditolak. Artinya tidak ada pengaruh Kegiatan Senam Irama terhadap kemampuan kinestetik anak kelompok B di TK PGRI Tanjung Batu, Kebupaten Ogan Ilir. Kegiatan Senam Irama yang sudah peneliti lakukan tidak berpengaruh di TK tersebut, dimana anak-anak tersebut baru pertama kali melakukan kegiatan senam ini. Hal ini dikarenakan TK tersebut hanya fokus kepada calistung (membaca, menulis dan berhitung) sehingga selama kegiatan penelitian berlangsung anak-anak antusias mengikuti kegiatan penelitian sampai dengan selesai. Kegiatan mengembangkan kemampuan kinestetik anak akan terus dilanjutkan oleh tenaga pendidik di TK PGRI, dimana peneliti sudah memberikan alat dan bahan untuk membantu pendidik dalam mengembangkan kemampuan kinestetik anak usia dini.
Pengaruh Metode Storytelling Terhadap Peningkatan Minat Baca Anak Usia 5-6 Tahun Di TK Marfu’ah Palembang
Authors: Purnia Carlis , Fitri Izza , Febriyanti Febriyanti 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Metode Storytelling Terhadap peningkatan Minat Baca Anak Usia 5-6 Tahun di TK Marfu’ah Palembang. Jenis penelitian ini adalah pre-experimental design dengan desain One Group Pretest -Posttest. Jumlah sampel adalah 10 orang anak. Teknik pengempulan Data dalam penelitian ini menggunakan observasi, wawancara dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah menggunakan uji normalitas, uji homogenitas, dan uji hipoteisi. Berdasarkan hasil penelitian yang didapat bahwa ada perbedaan anatara nilai pretest dan postest, diman prestest dengan rata-rata 56,4 sedangkan postest dengan nilai rata-rata 115,2 yang berati nilai setelah diberikan treatment membuahkan hasil. Dengan menggunakan metode storytelling dapat berpengaruh terhadap peningkatan Minat Baca anak usia 5-6 tahun di tk marfu’ah palembang. Yang dapat dilihat kembali pada sig (2-tailed)= 0.000 karena signifikan (probabilitas) lebih kecil dari 0.05. maka Ho di tolak dan Ha di terima.
Supporting the Biomedical Science UG Project Research Journey Through Staff-Student Partnerships
Authors: Veuger S. , Cookson L. , Creighton H. , Gallaher S. , Racey S. , Ridley M. , Robson I. 
Published: May 2024

Introduction: Developing research skills enhances graduate attributes and student employability. The UG research project is coined the pedagogy of the 21st century but the diversity of supervisory styles is a source of student perceived inequality of experience. The goal of this study was to provide structure and support to undergraduate (UG) biomedical science research students and supervisors by co-creating research informed resources that are accessible, engaging and student centred. We asked 1) How do UG students experience research supervision? 2) What approaches do supervisors use to support UG project students? 3) How do students as partners benefit from being involved in pedagogical research?Materials and Methods: In Stage One, 3 UG student research partners co-developed questionnaires and followed these up with semi-structured interviews. Fifty two UG project students took part in an interactive poll and 14 supervisors answered a questionnaire. Seven students and 4 supervisors were interviewed. These were analysed by thematic analysis. In Stage Two, the questions were asked of UG project students (n = 79) via an interactive poll and the resource developed in Stage One was trialled with students (n = 68) and supervisors (n = 37).Results: The global theme identified was that students feel strongly that the student-supervisor relationship influences their experience, satisfaction and success. In all polls, &gt;90% of students but &lt;60% of supervisors agree that a good student/supervisor partnership has an effect on the success of the final project. A smaller percentage of students felt strongly that they were able to develop a successful partnership with their supervisor. We co-created a visual model and a list of discussion points of how the student-supervisor partnership can be developed, aimed at making supervision more effective whilst being non-prescriptive.Discussion: The resource can be easily adapted. Students believe it helped them to develop a staff-student partnership and supervisors commented that it helps to clarify roles and manage student expectations. This scalable project will support the practice of future UG biomedical science project research students and supervisors. Working with students as partners enabled the development of richer ideas whilst supporting their employability.
Liraglutide, a glucagon-like peptide-1 receptor agonist, inhibits bone loss in an animal model of osteoporosis with or without diabetes
Authors: Wu Zongyi , Deng Wei , Ye Yiming , Xu Jie , Han Deyu , Zheng Yu , Zheng Qun 
Published: May 2024

IntroductionLiraglutide (Lrg), a novel anti-diabetic drug that mimics the endogenous glucagon-like peptide-1 to potentiate insulin secretion, is observed to be capable of partially reversing osteopenia. The aim of the present study is to further investigate the efficacy and potential anti-osteoporosis mechanisms of Lrg for improving bone pathology, bone- related parameters under imageology, and serum bone metabolism indexes in an animal model of osteoporosis with or without diabetes. MethodsEight databases were searched from their inception dates to April 27, 2024. The risk of bias and data on outcome measures were analyzed by the CAMARADES 10-item checklist and Rev-Man 5.3 software separately.ResultsSeventeen eligible studies were ultimately included in this review. The number of criteria met in each study varied from 4/10 to 8/10 with an average of 5.47. The aspects of blinded induction of the model, blinding assessment of outcome and sample size calculation need to be strengthened with emphasis. The pre-clinical evidence reveals that Lrg is capable of partially improving bone related parameters under imageology, bone pathology, and bone maximum load, increasing serum osteocalcin, N-terminal propeptide of type I procollagen, and reducing serum c-terminal cross-linked telopeptide of type I collagen (P&lt;0.05). Lrg reverses osteopenia likely by activating osteoblast proliferation through promoting the Wnt signal pathway, p-AMPK/PGC1α signal pathway, and inhibiting the activation of osteoclasts by inhibiting the OPG/RANKL/RANK signal pathway through anti-inflammatory, antioxidant and anti-autophagic pathways. Furthermore, the present study recommends that more reasonable usage methods of streptozotocin, including dosage and injection methods, as well as other types of osteoporosis models, be attempted in future studies. DiscussionBased on the results, this finding may help to improve the priority of Lrg in the treatment of diabetes patients with osteoporosis.
Maternal thyroid function and offspring birth anthropometrics in women with polycystic ovary syndrome
Authors: Trouva Anastasia , Alvarsson Michael , Calissendorff Jan , Åsvold Bjørn Olav , Ujvari Dorina , Hirschberg Angelica Lindén , Vanky Eszter 
Published: May 2024

ObjectivesPolycystic ovary syndrome (PCOS) and thyroid disorders have both been linked to adverse pregnancy and neonatal outcomes. Even small variations in thyroid function within the normal range may influence fetal growth. Our aim was to investigate whether maternal thyroid function is associated with newborn anthropometrics in PCOS and explore the potential modifying effect of metformin.MethodsPost-hoc analyses of two RCTs in which pregnant women with PCOS were randomized to metformin or placebo, from first trimester to delivery. Maternal serum levels of thyroid stimulating hormone (TSH) and free thyroxine (fT4) were measured at gestational weeks (gw) 5–12, 19, 32 and 36 in 309 singleton pregnancies. The mean z-scores of birthweight, birth length, and head circumference were estimated in the offspring. Associations of maternal thyroid parameters with offspring anthropometrics and the outcomes large for gestational age (LGA) and small for gestational age (SGA) were studied using linear and logistic regression models, with adjustment for body mass index (BMI) when relevant.ResultsMaternal fT4 at baseline was negatively associated with birth length (b= -0.09, p=0.048). Furthermore, ΔfT4 during pregnancy correlated positively to z-score of both birth weight and length (b=0.10, p=0.017 and b=0.10, p=0.047 respectively), independently of treatment group. TSH at baseline and gw19 was inversely associated with LGA (OR 0.47, p=0.012 and OR 0.58, p=0.042), while ΔTSH was positively associated with LGA (OR 1.99, p=0.023). There were inverse associations between TSH at baseline and SGA (OR 0.32, p=0.005) and between ΔfT4 and SGA (OR 0.59, p=0.005) in the metformin group only. There were no associations between maternal thyroid function and head circumference of the newborns.ConclusionIn women with PCOS, a higher maternal fT4 in early pregnancy and a greater decrease in fT4 during pregnancy was associated with a lower offspring birthweight and shorter birth length. Higher TSH by mid-gestation and smaller increase in TSH during pregnancy was associated with less risk of LGA. Subclinical variations in maternal thyroid function might play a role for birth anthropometrics of PCOS offspring.
Causal association of immune cells and endometriosis: a Mendelian randomization study
Authors: Fang Xingyi , Deng Qinghua , Yang Haili , Yan Zhaohua , Peng Zhen , Zhao Yuheng , Liao Tantan , Tu Ziying , Liu Jia , Liu Li , Zou Lin , He Honghua 
Published: May 2024

ObjectiveTo investigate the causal effect of immune cells on endometriosis (EMS), we performed a Mendelian randomization analysis.MethodsMendelian randomization (MR) uses genetic variants as instrumental variables to investigate the causal effects of exposures on outcomes in observational data. In this study, we conducted a thorough two-sample MR analysis to investigate the causal relationship between 731 immune cells and endometriosis. We used complementary Mendelian randomization (MR) methods, including weighted median estimator (WME) and inverse variance weighted (IVW), and performed sensitivity analyses to assess the robustness of our results.ResultsFour immune phenotypes have been found to be significantly associated with the risk of developing EMS: B cell %lymphocyte (WME: OR: 1.074, p = 0.027 and IVW: OR: 1.058, p = 0.008), CD14 on Mo MDSC (WME: OR: 1.056, p =0.021 and IVW: OR: 1.047, p = 0.021), CD14+ CD16− monocyte %monocyte (WME: OR: 0.947, p = 0.024 and IVW: OR: 0.958, p = 0.011), CD25 on unsw mem (WME: OR: 1.055, p = 0.030 and IVW: OR: 1.048, p = 0.003). Sensitivity analyses confirmed the main findings, demonstrating consistency across analyses.ConclusionsOur MR analysis provides compelling evidence for a direct causal link between immune cells and EMS, thereby advancing our understanding of the disease. It also provides new avenues and opportunities for the development of immunomodulatory therapeutic strategies in the future.
Sex differences in the combined influence of inflammation and nutrition status on depressive symptoms: insights from NHANES
Authors: Xu Yifeng , Yan Zhaoqi , Liu Liangji 
Published: May 2024

BackgroundBoth nutrition and inflammation are associated with depression, but previous studies have focused on individual factors. Here, we assessed the association between composite indices of nutrition and inflammation and depression.MethodsAdult participants selected from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018 were chosen. The exposure variable was the Advanced Lung Cancer Inflammation Index (ALI) integrating nutrition and inflammation, categorized into low, medium, and high groups. The outcome variable was depression assessed using the Patient Health Questionnaire-9 (PHQ-9). A multivariable logistic regression model was employed to evaluate the relationship between ALI and the risk of depression.ResultsAfter extensive adjustment for covariates, in the overall population, participants with moderate and high levels of ALI had a decreased prevalence of depression compared to those with low ALI levels, with reductions of 17% (OR, 0.83; 95% CI: 0.72–0.97) and 23% (OR, 0.77; 95% CI: 0.66–0.91), respectively. Among females, participants with moderate and high ALI levels had a decreased prevalence of depression by 27% (OR, 0.73; 95% CI: 0.60–0.88) and 21% (OR, 0.79; 95% CI: 0.64–0.98), respectively, compared to those with low ALI levels, whereas no significant association was observed among males. Subgroup analyses based on females and males yielded consistent results.ConclusionIn this study, we observed a negative correlation between moderate to high levels of ALI and the prevalence of depression, along with gender differences. Specifically, in females, greater attention should be given to the nutritional and inflammatory status.
Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis
Authors: Chen Jing , Zhu Qiaozhen , Li Lan , Xue Zheng 
Published: May 2024

BackgroundRecent observational research suggests a potential link between celiac disease (CeD) and an increased incidence of attention-deficit/hyperactivity disorder (ADHD). However, the genetic relationship between CeD and ADHD remains unclear. In order to assess the potential genetic causality between these two conditions, we conducted a Mendelian randomization (MR) analysis.MethodsWe performed a bidirectional MR analysis to investigate the relationship between CeD and ADHD. We carefully selected single nucleotide polymorphisms (SNPs) from publicly available large-scale genome-wide association studies (GWAS) databases, employing rigorous quality screening criteria. MR estimates were obtained using four different methods: fixed-effect inverse variance weighted (fe-IVW), random-effect inverse variance weighting (re-IVW), weighted median (WM), and MR-Egger. The robustness and reliability of our findings were confirmed through sensitivity analyses, assessment of instrumental variable (IV) strength (F-statistic), and statistical power calculations.ResultsOur MR analyses did not reveal any significant genetic associations between CeD and ADHD (fe-IVW: OR = 1.003, 95% CI = 0.932–1.079, P = 0.934). Similarly, in the reverse direction analysis, we found no evidence supporting a genetic relationship between ADHD and CeD (fe-IVW: OR = 0.850, 95% CI = 0.591–1.221, P = 0.378). Various MR approaches consistently yielded similar results. Sensitivity analysis indicated the absence of significant horizontal pleiotropy or heterogeneity. However, it’s important to note that the limited statistical power of our study may have constrained the causal analysis of the exposure’s influence on the outcome.ConclusionsOur findings do not provide compelling evidence for a genetic association between CeD and ADHD within the European population. While the statistical power of our study was limited, future MR research could benefit from larger-scale datasets or datasets involving similar traits. To validate our results in real-world scenarios, further mechanistic studies, large-sample investigations, multicenter collaborations, and longitudinal studies are warranted.
Expert opinions on improving coercion data collection across Europe: a concept mapping study
Authors: Lickiewicz Jakub , Efkemann Simone Agnes , Husum Tonje Lossius , Lantta Tella , Pingani Luca , Whittington Richard 
Published: May 2024

IntroductionCoercion is frequently used in mental health practice. Since it overrides some patients’ fundamental human rights, adequate use of coercion requires legal and ethical justifications. Having internationally standardised datasets to benchmark and monitor coercion reduction programs is desirable. However, only a few countries have specific, open, publicly accessible registries for this issue.MethodsThis study aims to assemble expert opinions regarding strategies that might be feasible for promoting, developing, and implementing an integrated and differentiated coercion data collection system in Europe at national and international levels. A concept mapping methodology was followed, involving 59 experts from 27 countries in generating, sorting and rating strategies regarding relevance and feasibility. The experts were all researchers and/or practitioner members of an EU-COST-Action focused on coercion reduction Fostering and Strengthening Approaches to Reducing Coercion in European Mental Health Services (FOSTREN).ResultsA hierarchical cluster analysis revealed a conceptual map of 41 strategies organized in seven clusters. These clusters fit into two higher-order domains: “Advancing Global Health Research: Collaboration, Accessibility, and Technological Innovations/Advancing International Research” and “Strategies for Comprehensive Healthcare Data Integration, Standardization, and Collaboration.” Regarding the action with the higher priority, relevance was generally rated higher than feasibility. No differences could be found regarding the two domains regarding the relevance rating or feasibility of the respective strategies in those domains. The following strategies were rated as most relevant: “Collection of reliable data”, “Implementation of nationwide register, including data on coercive measures”, and “Equal understanding of different coercive measures”. In analysing the differences in strategies between countries and their health prosperity, the overall rating did not differ substantially between the groups.ConclusionThe strategy rated as most relevant was the collection of reliable data in the nationwide health register, ensuring that countries share a standard understanding/definition of different coercive measures. Respondents did not consider the feasibility of establishing a shared European database for coercive measures to be high, nor did they envision the unification of mental health legislation in the future. There is some consensus on the most suitable strategies that can be adopted to enable international benchmarking of coercion in mental health settings.
Pre-Transplant Frequencies of FoxP3+CD25+ in CD3+CD8+ T Cells as Potential Predictors for CMV in CMV-Intermediate Risk Kidney Transplant Recipients
Authors: Mooslechner Agnes A. , Schuller Max , Pfeifer Verena , Klötzer Konstantin A. , Prietl Barbara , Kirsch Alexander H. , Stiegler Philipp , Sucher Robert , Sourij Harald , Rosenkranz Alexander R. , Eller Kathrin 
Published: May 2024

Cytomegalovirus (CMV) infection detrimentally influences graft survival in kidney transplant recipients, with the risk primarily determined by recipient and donor serostatus. However, recipient CD8+ T cells play a crucial role in CMV control. The optimal preventive strategy (prophylaxis vs. pre-emptive treatment), particularly for seropositive (intermediate risk) recipients, remains uncertain. We investigated CD8+ T cell subpopulation dynamics and CMV occurrence (DNAemia ≥ 100 IU/mL) in 65 kidney transplant recipients, collecting peripheral blood mononuclear cells before (T1) and 1 year after transplantation (T2). Comparing the two timepoints, we found an increase in granulocyte, monocyte and CD3+CD8+ T cells numbers, while FoxP3+CD25+, LAG-3+ and PD-1+ frequencies were reduced at T2. CMV DNAemia occurred in 33 recipients (55.8%) during the first year. Intermediate risk patients were disproportionally affected by posttransplant CMV (N = 29/45, 64.4%). Intermediate risk recipients developing CMV after transplantation exhibited lower leukocyte, monocyte, and granulocyte counts and higher FoxP3+CD25+ frequencies in CD3+CD8+ T cells pre-transplantation compared to patients staying CMV negative. Pre-transplant FoxP3+CD25+ in CD3+CD8+ T cells had the best discriminatory potential for CMV infection prediction within the first year after transplantation (AUC: 0.746). The FoxP3+CD25+ CD3+CD8+ T cell subset may aid in selecting intermediate risk kidney transplant recipients for CMV prophylaxis.