bluuebunny/crossref_metadata_2025_split huggingface dataset:
How can food extracts consumed in the Mediterranean and East Asia suppress prostate cancer proliferation?
Authors: Yao Mu , Xie Chanlu , Constantine Maryrose , Hua Sheng , Hambly Brett D. , Jardine Greg , Sved Paul , Dong Qihan 
Published: November 2011

We have developed a blend of food extracts commonly consumed in the Mediterranean and East Asia, named blueberry punch (BBP), with the ultimate aim to formulate a chemoprevention strategy to inhibit prostate cancer progression in men on active surveillance protocol. We demonstrated previously that BBP inhibited prostate cancer cell proliferationin vitroandin vivo. The purpose of this study was to determine the molecular mechanism responsible for the suppression of prostate cancer cell proliferation by BBP. Treatment of lymph node-metastasised prostate cancer cells (LNCaP) and bone-metastasised prostate cancer cells (PC-3 and MDA-PCa-2b) with BBP (up to 0·8 %) for 72 h increased the percentage of cells at the G0/G1phase and decreased those at the S and G2/M phases. The finding was supported by the reduction in the percentage of Ki-67-positive cells and of DNA synthesis measured by the incorporation of 5-ethynyl-2′-deoxyuridine. Concomitantly, BBP treatment decreased the protein levels of phosphorylated retinoblastoma, cyclin D1 and E, cyclin-dependent kinase (CDK) 4 and 2, and pre-replication complex (CDC6 and MCM7) in LNCaP and PC-3 cells, whereas CDK inhibitor p27 was elevated in these cell lines. In conclusion, BBP exerts its anti-proliferative effect on prostate cancer cells by modulating the expression and phosphorylation of multiple regulatory proteins essential for cell proliferation.
The Returns of Theory
Authors: Tageldin Shaden M. 
Published: November 2011

For the discipline of Arabic literature in the United States, “theory” is a double entendre: promise, danger. Until the mid-1990s, U.S. Arabic literary studies was landlocked in Near Eastern language departments, whose “anti-theoretical” bent Magda Al-Nowaihi imputes to dependence on U.S. government and Gulf state support. Theory is “dangerous” to such funders, Al-Nowaihi maintains, because it traffics in “the relations between knowledge and power. . . . The result is a situation where European departments produce the theory, we provide the raw material.” “Theory” is what Arabic literature needs—to become a site and an agent of aesthetic-political critique—yet lacks because powers of state insulate its energies within microtextual hermeneutics. Uniquely empowered to translate Arabic literature from particularist “ghetto” to universalist (Euro-dominant) “center” through the abstracting medium of “theory,” then, “European departments” control Arabic literature's legitimization. What emerges is a curious chiasmus: “theory” is at once a danger to state power and a desideratum for Arabic literature, on the one hand, and a seat of institutional power within the U.S. humanities and a danger to Arabic literature, on the other.
YOUTH AS PERIL AND PROMISE: THE EMERGENCE OF ADOLESCENT PSYCHOLOGY IN POSTWAR EGYPT
Authors: El Shakry Omnia 
Published: November 2011

AbstractA public discourse of “youth crisis” emerged in 1930s Egypt, partly as a response to the widespread student demonstrations of 1935 and 1936 that ushered in the figure of youth as an insurgent subject of politics. The fear of youth as unbridled political and sexual subjects foreshadowed the emergence of a discourse of adolescent psychology. By the mid-1940s, “adolescence” had been transformed into a discrete category of analysis within the newly consolidated disciplinary space of psychology and was reconfigured as a psychological stage of social adjustment, sexual repression, and existential anomie. Adolescence—perceived as both a collective temporality and a depoliticized individual interiority—became a volatile stage linked to a psychoanalytic notion of sexuality as libidinal raw energy, displacing other collective temporalities and geographies. New discursive formations, for example, of a psychology centered on unconscious sexual impulses and a cavernous interiority, and new social types, such as the “juvenile delinquent,” coalesced around the figure of adolescence in postwar Egypt.
Burying the hatchet? Britain and France in the Democratic Republic of Congo
Authors: Cumming Gordon D. 
Published: November 2011

ABSTRACTAgainst the background of conflict in the Great Lakes Region, the UK and France promised, at their 1998 Saint-Malo summit, to set aside rivalries and cooperate on Africa. In subsequent Anglo-French gatherings, they singled out the DRC and pledged to work together there to promote peace and tackle poverty. This article asks whether this coordination took place and whether it involved a ‘deconflictualisation’ of approaches, ‘coincidental’ cooperation, or ‘sustained and reciprocal’ collaboration. It looks for evidence of institutionalisation of UK-French ties and policy cooperation in the fields of peacebuilding and poverty reduction. It then identifies the pressures for, and barriers to, collaboration, focusing particularly on the role of interests, foreign policy norms, institutional factors and resource constraints. It concludes by setting out the wider implications of UK-French cooperation and the limited prospects of closer future collaboration.
From South Africa with love: the malayisha system and Ndebele households' quest for livelihood reconstruction in south-western Zimbabwe
Authors: Thebe Vusilizwe 
Published: November 2011

ABSTRACTIn the 1980s and early 1990s, sending remittances from South Africa posed major challenges for Ndebele migrants. As a result households receiving remittances only did so at irregular intervals. With increased diasporisation into South Africa, it was to be expected that new channels would open up. This article explores what is known as the malayisha system, its role and significance as an informal channel of remittances into Ndebele society. It argues that the system bridged the geographical gap between Matabeleland and Johannesburg, averting food insecurity and poverty for semi-proletarian households in Matabeleland. By facilitating the movement of goods and people between Matabeleland and South Africa, the system became instrumental in the quest of households to reconstruct their livelihoods after the destruction of their rural–urban-based livelihoods in Zimbabwe due to perennial droughts and ESAP. As a result, the services of omalayisha are highly sought-after, by both the migrant community in South Africa and households in Matabeleland.
Assessment of the viability of embryos stored in liquid nitrogen produced commercially using culture medium as a complementary test for stereoscopic microscopy
Authors: Godinez B. , Galina C.S. , Leon H. , Gutierrez M. , Moreno-Mendoza N. 
Published: November 2011

SummaryThe objective of the present study was to evaluate the viability of frozen embryos obtained from various private farmers in a culture medium for 4 h. Forty-seven embryos were used that had been previously graded as good and fair. These embryos were evaluated using stereoscopic microscopy by experienced clinicians prior to freezing. Embryos were divided in two groups: the non-cultured group, made up of six good quality embryos, and five fair; and the cultured group that consisted of 20 good quality embryos and 16 fair. Fifty-four per cent of the good quality embryos achieved a favourable development during culture whereas just 42% of embryos determined to be fair were observed to have adequate development. This evaluation was undertaken by serial photographs obtained at the onset of culture and 4 h later. This finding was corroborated by a more specific technique: terminal deoxynucleotide transferase dUTP nick end labelling–bromodeoxyuridine (TUNEL–BrdU). These results are indicative of the necessity of tight quality controls for commercially produced frozen embryos, as once thawed it is unlikely that clinicians will examine them to determine their physiological status prior to transfer.
QT dispersion and cardiac involvement in children with Familial Mediterranean fever
Authors: Koca Bülent , Kasapçopur Özgür , Bakari Süleyman , Sönmez Emine , Öztunç Funda , Eroğlu Ayşe Güler , Saltik Levent , Calay Özden 
Published: November 2011

AbstractFamilial Mediterranean fever is a hereditary disease characterised by recurrent and self-terminated attacks of fever and polyserositis. An earlier study found that adult patients of Familial Mediterranean fever had an abnormally longer QT dispersion and corrected QT dispersion, markers for ventricular arrhythmogenicity. QT dispersion is a simple non-invasive arrhythmogenic marker that can be used to assess homogeneity of cardiac repolarisation; however, it has not been studied in children with Familial Mediterranean fever before. The aim of this study was to assess QT dispersion and corrected QT dispersion, and their relationship with systolic and diastolic function of the left ventricle in a group of children with Familial Mediterranean fever. We performed electrocardiography and Doppler echocardiography on patients and controls. Maximum QT, minimum QT, QT dispersion, corrected QT, maximum corrected QT, minimum corrected QT, and corrected QT dispersion intervals were measured from standard 12-lead electrocardiography. No statistically significant differences were found between the groups in QT dispersion, corrected QT dispersion, and systolic–diastolic function of the left ventricle parameters. During the 12 months of follow-up, no ventricular arrhythmias were documented in either group.
Innominate vein vascular ring provides novel insight into systemic venous embryogenesis
Authors: Pockett Charissa R. , Soni Reeni , Mackie Andrew S. 
Published: November 2011

AbstractAnomalies of the innominate vein are uncommon in congenital cardiac disease. We report a case of duplicate innominate veins forming a vascular ring encircling the ascending aorta. We postulate that this vascular ring represents the failure of both a dorsal and ventral precardinal anastomosis to regress.
Balloon atrial septostomy and pre-operative brain injury in neonates with transposition of the great arteries: a systematic review and a meta-analysis
Authors: Polito Angelo , Ricci Zaccaria , Fragasso Tiziana , Cogo Paola E. 
Published: November 2011

AbstractObjectiveTo perform a systematic review and a meta-analysis of the effects of balloon atrial septostomy on peri-operative brain injury in neonates with transposition of the great arteries.Data sourceWe conduct a systematic review of the literature to identify all observational studies that included neonates born with transposition of the great arteries who had peri-operative evidence of brain injury.Study selection and data extractionThe search strategy produced three prospective and two retrospective cohort studies investigating the association between balloon atrial septostomy and brain injury totalling 10,108 patients. In two studies, the outcome was represented by the presence of a coded diagnosis of a clinically evident stroke at discharge, whereas in three studies the outcome was represented by the finding of pre-operative brain injury identified by magnetic resonance scans.Data synthesisThe overall brain injury rate for neonates who underwent balloon atrial septostomy versus control patients was 60 of 2273 (2.6%) versus 45 of 7835 (0.5%; pooled odds ratio, 1.90; 95% confidence intervals, 0.93–3.89; p = 0.08). A subgroup analysis of the three studies that used pre-operative brain injury as the primary outcome found no significant association between balloon atrial septostomy and brain injury (pooled odds ratio, 2.70; 95% confidence intervals, 0.64–11.33; p = 0.17). Balloon atrial septostomy frequency was 22.4% (2273 of 10,108), with reported rates ranging from 20% to 75%.ConclusionOur analysis shows that balloon atrial septostomy is not associated with increased odds for peri-operative brain injury. Balloon atrial septostomy should still be used for those patients with significant hypoxaemia, haemodynamic instability, or both.
Automated Grain Mapping Using Wide Angle Convergent Beam Electron Diffraction in Transmission Electron Microscope for Nanomaterials
Authors: Kumar Vineet 
Published: November 2011

AbstractThe grain size statistics, commonly derived from the grain map of a material sample, are important microstructure characteristics that greatly influence its properties. The grain map for nanomaterials is usually obtained manually by visual inspection of the transmission electron microscope (TEM) micrographs because automated methods do not perform satisfactorily. While the visual inspection method provides reliable results, it is a labor intensive process and is often prone to human errors. In this article, an automated grain mapping method is developed using TEM diffraction patterns. The presented method uses wide angle convergent beam diffraction in the TEM. The automated technique was applied on a platinum thin film sample to obtain the grain map and subsequently derive grain size statistics from it. The grain size statistics obtained with the automated method were found in good agreement with the visual inspection method.
Haben sich motorische Leistungen von 3- bis 7-jährigen Jungen und Mädchen im Zeitraum von 1973 bis 2001 verschlechtert?
Authors: Krombholz Heinz 
Published: November 2011

Zusammenfassung.Die motorische Leistungsfähigkeit von Kindern im Alter von 3–7 Jahren wurde anhand vorliegender Untersuchungsergebnisse aus den Jahren 1973 (N = 375), 1973/74 (N = 123), 1977 (N = 644) und 1999/2001 (N = 1532) verglichen. Die erfassten motorischen Leistungen waren Standweitsprung und die Aufgaben Balancieren Rückwärts und Seitliches Hin- und Herspringen des Körperkoordinationstests für Kinder KTK (Kiphard & Schilling 1974). Innerhalb der überprüften Zeitspanne konnte eine generelle Verschlechterung der motorischen Leistungsfähigkeit nicht belegt werden. Unterschiede zwischen den Stichproben ließen sich eher auf Besonderheiten der jeweiligen Stichproben als auf den jeweiligen Erhebungszeitpunkt zurückführen. Ebenfalls konnten Erwartungen hinsichtlich einer unterschiedlichen Veränderung der Leistungsfähigkeit bei Jungen und Mädchen nicht bestätigt werden.
Crustal structure of Australia from ambient seismic noise tomography
Authors: Saygin Erdinc , Kennett B. L. N. 
Published: November 2011

Surface wave tomography for Australian crustal structure has been carried out using group velocity measurements in the period range 1–32 s extracted from stacked correlations of ambient noise between station pairs. Both Rayleigh wave and Love wave group velocity maps are constructed for each period using the vertical and transverse component of the Green's function estimates from the ambient noise. The full suite of portable broadband deployments and permanent stations on the continent have been used with over 250 stations in all and up to 7500 paths. The permanent stations provide a useful link between the various shorter‐term portable deployments. At each period the group velocity maps are constructed with a fully nonlinear tomographic inversion exploiting a subspace technique and the Fast Marching Method for wavefront tracking. For Rayleigh waves the continental coverage is good enough to allow the construction of a 3D shear wavespeed model in a two stage approach. Local group dispersion information is collated for a distribution of points across the continent and inverted for a 1D SV wavespeed profile using a Neighbourhood Algorithm method. The resulting set of 1D models are then interpolated to produce the final 3D wavespeed model. The group velocity maps show the strong influence of thick sediments at shorter periods, and distinct fast zones associated with cratonic regions. Below the sediments the 3D shear wavespeed model displays significant heterogeneity with only moderate correlation with surface tectonic features. For example, there is no evident expression of the Tasman Line marking the eastern edge of Precambrian outcrop. The large number of available inter‐station paths extracted from the ambient noise analysis provide detailed shear wavespeed information for crustal structure across the Australian continent for the first time, including regions where there was no prior sampling because of difficult logistics.
Bird surveys for REDD+: avian communities indicate forest degradation in a Peruvian coffee landscape
Authors: Aerts Raf , Spranghers Sarah , Verbist Bruno , Lens Luc , Sekercioglu Cagan 
Published: November 2011

AbstractShade coffee cultivation in the Peruvian Andes assists in reducing emissions from deforestation because it avoids conversion to non-forest land uses such as coca and sun grown coffee farming. REDD+ is a potential finance mechanism which may provide incentives for local coffee cooperatives to maintain high shade tree cover. REDD+ has potential multiple benefits other than carbon sequestration, including the conservation of biodiversity. When monitoring for REDD+, surveys of bird biodiversity may prove to be particularly valuable: apart from their high intrinsic value and their value as essential ecosystem service providers, birds inhabiting forest habitats are extremely sensitive to forest loss and forest degradation and are therefore potential useful indicators for the impact of habitat and climate disturbances on biodiversity and environmental health.We analyzed the impact of coffee cultivation on the conservation of birds and assessed what can be learned from bird surveys when monitoring the Peruvian mountain forests for REDD+. Using twelve day-long transect walks, bird species were recorded in two sites in the buffer zone of the Bahuaja-Sonene National Park in SE Peru. The two sites had contrasting human pressure: one site an intimate mixture of shade coffee plantations, orchards, secondary forest patches and coca plantations and the other site secondary forest with patchily distributed shade coffee, fruit and coca plantations. An indirect gradient approach (non-metric multidimensional scaling and multi-response permutation procedure tests) was used to detect differences in forest degradation between sites.In a two-dimensional ordination space, individual counts of the less disturbed site were separated from the other counts, but sites did not differ significantly at the community-level. Observed birds were indicative for one habitat type. The bird assemblage was dominated by species of forest edges and second growth habitat (78%). The majority of species (68%) had a wide range covering Amazonia and the east slopes of the Andes; only 25 species (29%) were more or less restricted to Andes and the outlying ridges.The current state of the forest, in both sites with contrasting human influence, can be described as disturbed secondary montane evergreen forest of the transition zone between the Andes and the Amazon. Despite severe human impact, several forest specialists (22%) of both Andean montane and Amazonian forest persisted –including the enigmatic Andean cock-of-the-rock and Military macaw. For such species, REDD+ projects should not only focus on the sustainable management of the shade coffee stands but also aim to conserve the remaining old-growth secondary forest patches.
Determining the Waist Circumference Cut off which Best Predicts the Metabolic Syndrome components in urban Africans: The SABPA study
Authors: Prinsloo J. , Malan L. , de Ridder J. , Potgieter J. , Steyn H. 
Published: November 2011

AbstractVarious studies have shown that the relationship between waist circumference (WC) and abdominal obesity is age, gender as well as ethnicity-dependent. WC criteria for Sub Saharan Africans have not been defined by the International Diabetes Federation (IDF). The aim was to determine which WC cut off best predicted Metabolic Syndrome (MetS) in a group of urban African teachers (80 males and 93 females). We determined sphygmomanometer blood pressure, WC, glucose, high density lipoprotein cholesterol (HdL) and triglyceride (TRIG) values. The males′ MetS profile was less favourable as their glucose, TRIG and blood pressure levels were higher than the proposed cut off for MetS. The females could be classified as obese, based on their mean BMI (32.78±6.36) and WC (93.48±15.68). Receiver operating characteristic (ROC) WC cut offs of 90, 91, 94 and 96 cm for the respective MetS components in males (blood pressure, HdL, glucose and TRIG) were suggested. In the females, cut offs of 92, 98, 94 and 94 cm for TRIG, blood pressure, HdL and glucose respectively, were put forward. Odds ratios revealed that increased blood pressure best predicted ROC WC in both males (OR 9.59; 95% CI 3.14–29.32) and females (OR 3.11; 95% CI 1.30–7.42) irrespective of age. We suggest that the optimal cut off point for the males be set at 90 cm, as opposed to the current 94 cm; whilst the female cut off be set at 98 cm as opposed to the existing cut off of 80 cm. Larger sample groups are recommended to justify our data.
Low-Level Subchronic Arsenic Exposure from Prenatal Developmental Stages to Adult Life Results in an Impaired Glucose Homeostasis
Authors: Dávila-Esqueda M. , Morales J. , Jiménez-Capdeville M. , De la Cruz E. , Falcón-Escobedo R. , Chi-Ahumada E. , Martin-Pérez S. 
Published: November 2011

AbstractWe evaluated how low-level (3 ppm) subchronic inorganic arsenic (iAs) exposure from prenatal developmental stages until adult life affects glucose homeostasis. Biochemical parameters of glucose and lipid metabolism, pancreatic insulin and glycosylated haemoglobin were determined in 4-month-old female offspring of adult Wistar rats. Pancreatic histology was also performed. Statistical comparisons between control and iAs-treated groups were performed by unpaired two-tailed Student’s t-test. Statistical significance was set at p<0.05. We found that iAs treatment resulted in an impaired glucose tolerance test, suggestive of impaired glucose metabolism. This group was found to have hyperglycaemia and high levels of HOMA-IR, glycosylated haemoglobin, cholesterol and pancreatic insulin compared to control rats. However, plasma insulin, triglycerides and high-density lipoprotein cholesterol were not different from control rats. Moreover, β-cell damage found in iAs-treated rats consisted of cells with a nucleus with dense chromatin and predominance of eosinophilic cytoplasm, as well as changes in the pancreatic vasculature. The current study provided evidence that subchronic iAs exposure at 3 ppm from prenatal developmental stages to adult life resulted in damage to pancreatic β cells, affected insulin secretion and demonstrated altered glucose homeostasis, thus supporting a causal association between iAs exposure and diabetes.
Reduction of Insulin Signaling Upregulates Angiopoietin-like Protein 4 Through Elevated Free Fatty Acids in Diabetic Mice
Authors: Mizutani N. , Ozaki N. , Seino Y. , Fukami A. , Sakamoto E. , Fukuyama T. , Sugimura Y. , Nagasaki H. , Arima H. , Oiso Y. 
Published: November 2011

AbstractAngiopoietin-like protein 4 (Angptl4) is thought to cause an increase in serum triglyceride levels. In the present study, we elucidated Angptl4 expression in the mouse models of type 1 and type 2 diabetes mellitus, and investigated the possible mechanisms involved.Type 1 diabetes was induced in C57BL/6 J mice by treating them with streptozotocin (STZ). Type 2 diabetes was induced by feeding the mice a high-fat diet (HFD) for 18 weeks.The levels of Angptl4 mRNA expression in liver, white adipose tissue (WAT), and brown adipose tissue (BAT) were found to increase in the STZ diabetic mice relative to control mice. This effect was attenuated by insulin administration. In the HFD diabetic mice, the Angptl4 mRNA expression levels were increased in liver, WAT, and BAT. Treatment with metformin for 4 weeks attenuated the increased levels of Angptl4 mRNA. Fatty acids (FAs) such as palmitate and linoleate induced Angptl4 mRNA expression in H4IIE hepatoma cells and 3T3-L1 adipocytes. Treatment with insulin but not metformin attenuated FA-induced Angptl4 mRNA expression in H4IIE. Both insulin and metformin did not influence the effect of FAs in 3T3-L1 cells.These observations demonstrated that Angptl4 mRNA expression was increased through the elevated free FAs in diabetic mice.