bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple pseudoprogressions during ongoing immunotherapy-based treatment of advanced gastric neuroendocrine carcinoma: A case report and review of literature
Authors: Mou Yan-Hua , Zhang Juan , Shen Hui , Yu Jing , Han Lan , Li Hui , Li Qing-Feng 
Published: February 2025

BACKGROUND
Gastric neuroendocrine carcinomas (NECs) exhibit aggressive features, such as rapid growth, higher rate of metastasis, and a generally unfavorable prognosis compared to gastric adenocarcinoma. As a result, therapeutic options for NECs remain limited, contributing to the poor prognosis of patients. Immunotherapy has emerged as a promising treatment strategy and demonstrated the potential to partially improve the survival and prognosis of patients with NECs. Nevertheless, the unique clinical response termed pseudoprogression (PsP) has garnered considerable attention in the context of immunotherapy.
CASE SUMMARY
Presented here is a case of NEC recurrence five and a half months after radical gastric surgery. The 45-year-old male patient underwent combination treatment involving a PD-1 blocker and tyrosine kinase inhibitors and encountered two instances of PsP during treatment. The patient ultimately achieved a durable treatment response without altering his treatment regimens, resulting in a substantial therapeutic benefit.
CONCLUSION
This case report aimed to provide the authors’ experience with the diagnosis of PsP and treatment strategies for PsP in ongoing immunotherapy.
Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism
Authors: Wu Ling , Chen Hong-Yao , Zhang Jing-Ting , Yang Ren-Yi , Wang Zhi-Bin , Xue Pei-Sen , Peng Wei , Li Ke-Xiong , Gao Wen-Hui , Zeng Pu-Hua 
Published: February 2025

BACKGROUND
Ferroptosis is an iron-dependent programmed non-apoptotic cell death characterized by the accumulation of free iron ions and lipid peroxidation. It is associated with the inactivation of glutathione peroxidase (GPX) and the accumulation of lipid peroxides within cells. Ferroptosis is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Chlorogenic acid (CGA), an important bioactive component found in 61 traditional Chinese medicines such as Eucommia ulmoides , has been extensively studied for its effects on various malignant tumors. However, the specific role and potential mechanism of CGA in HCC remain unclear.
AIM
To elucidate the anti-tumor characteristics and potential mechanisms of CGA in inducing ferroptosis in HCC cells.
METHODS
The effects of CGA on the proliferation, migration, and invasion of HCC cells were evaluated through in vitro experiments. Bioinformatics analysis combined with network pharmacology was used to study the potential targets and molecular mechanisms of CGA intervention in HCC ferroptosis. In vitro experiments were conducted to verify and explore the anti-HCC effects and mechanisms of CGA through the ferroptosis pathway.
RESULTS
In vitro experiments showed that CGA dose-dependently inhibited the proliferation, invasion, and migration of HCC cells. Bioinformatics analysis combined with network pharmacology revealed that the pathway of CGA intervention in HCC cell ferroptosis was mainly enriched in the prostaglandin endoperoxide synthase 2 (PTGS2)/aldo-keto reductase family 1 member C3 (AKR1C3)/GPX4 signaling pathway, which was associated with arachidonic acid. In vitro experiments further confirmed that CGA-induced ferroptosis in HCC cells was related to mitochondrial damage through the reprogramming of arachidonic acid metabolism by regulating the PTGS2/AKR1C3/ GPX4 signaling pathway.
CONCLUSION
This study demonstrates that CGA inhibits HCC cell proliferation, migration, and invasion by inducing ferroptosis through the PTGS2/AKR1C3/GPX4 axis, suggesting its potential as a novel ferroptosis inducer or anti-HCC drug.
Políticas agrárias e o acesso à moradia: uma análise do cenário brasileiro
Authors: Garcia Ana Carolina de Morais , Freire Diego Sander , Andrade Amanda Barbosa , Silistrino Jean , Medeiros Laryssa Pereira de , Silva Wesley Leandro 
Published: February 2025

Este artigo aborda a função social da terra, um conceito fundamental na Constituição Brasileira que está relacionado ao direito à moradia. O direito à moradia é um direito humano crucial, mas a concentração da propriedade da terra dificulta o acesso a moradias adequadas. A função social da terra exige que a propriedade seja usada de maneira a atender às necessidades da população. O objetivo deste artigo é analisar a função social da terra, o Estatuto da Terra e a Reforma Agrária no contexto brasileiro, destacando como esses elementos estão interconectados. Além disso, o artigo busca compreender o papel do Movimento dos Trabalhadores Rurais Sem Terra (MST) na promoção do direito à moradia e na efetivação da função social da terra. A metodologia adotada neste artigo é baseada em análises históricas e jurídicas. Examina a evolução do conceito de função social da propriedade, destacando sua importância na legislação brasileira. Além disso, explora o Estatuto da Terra como uma legislação crucial no contexto agrário brasileiro e analisa o papel da Reforma Agrária na busca por uma distribuição mais equitativa de terras. O artigo também destaca o surgimento e a atuação do MST como um instrumento para garantir o direito à moradia. Os resultados destacam a importância da função social da terra como um conceito fundamental para garantir que a propriedade da terra seja usada de maneira produtiva e benéfica para toda a sociedade. Além disso, ressaltam a relevância do Estatuto da Terra como uma legislação abrangente que aborda questões relacionadas à propriedade rural e à Reforma Agrária. O MST emerge como um ator importante na luta pela reforma agrária e na promoção do direito à moradia, demonstrando como a redistribuição de terras pode ser uma solução para a concentração fundiária.Em conclusão, o artigo destaca que a função social da terra é essencial para garantir o direito à moradia e promover o desenvolvimento socioeconômico. O Estatuto da Terra desempenha um papel fundamental na regulamentação das questões agrárias no Brasil, enquanto o MST atua como um instrumento para pressionar por reformas e promover a redistribuição de terras. No contexto atual, a questão da terra no Brasil está intrinsecamente ligada à busca por justiça social e igualdade, e o cumprimento da função social da terra é crucial para atingir esses objetivos.
Refining remote sensing precipitation datasets in the South Pacific with an adaptive multi-method calibration approach
Authors: Mirones Óscar , Bedia Joaquín , Herrera Sixto , Iturbide Maialen , Baño Medina Jorge 
Published: February 2025

Abstract. Calibration techniques refine numerical model outputs for climate research, often preferred for their simplicity and suitability in many climate impact applications. Atmospheric pattern classifications for conditioned transfer function calibration, common in climate studies, are seldom explored for satellite product calibration, where significant biases may occur compared to in situ meteorological observations. This study proposes a new adaptive calibration approach, applied to the Tropical Rainfall Measuring Mission (TRMM) precipitation product across multiple stations in the South Pacific. The methodology involves the daily classification of the target series into five distinct weather types (WTs) capturing the diverse spatio-temporal precipitation patterns in the region. Various quantile mapping (QM) techniques, including empirical quantile mapping (eQM), parametric quantile mapping (pQM), and generalized Pareto distribution quantile mapping (gpQM), as well as an ordinary scaling, are applied to each WT. We perform a comprehensive validation by evaluating 10 specific precipitation-related indices that hold significance in impact studies, which are then combined into a single ranking framework (RF) score, which offers a comprehensive evaluation of the performance of each calibration method for every weather type. These indices are assigned user-defined weights, allowing for a customized assessment of their relative importance to the overall RF score. Thus, the adaptive approach selects the best performing method for each WT based on the RF score, yielding an optimally calibrated series. Our findings indicate that the adaptive calibration methodology surpasses standard and weather-type-conditioned methods based on a single technique, yielding more accurate calibrated series in terms of mean and extreme precipitation indices consistently across locations. Moreover, this methodology provides the flexibility to customize the calibration process based on user preferences, thereby allowing for specific indices, such as extreme rainfall indicators, to be assigned higher weights. This ability enables the calibration to effectively address the influence of intense rainfall events on the overall distribution. Furthermore, the proposed adaptive method is highly versatile and can be applied to different scenarios, datasets, and regions, provided that a prior weather typing exists to capture the pertinent processes related to regional precipitation patterns. Open-source code and illustrative examples are freely accessible to facilitate the application of the method.
Strategizing Cardiovascular Management in Diabetic Patients: Insights and Advancements from the 2023 ESC Guidelines for the Management of Cardiovascular Disease in Patients with Diabetes
Authors: Zhang Hongyuan , Green Darren , Liu Yanrong 
Published: February 2025

Communication
Strategizing Cardiovascular Management in Diabetic Patients: Insights and Advancements from the 2023 ESC Guidelines for the Management of Cardiovascular Disease in Patients with Diabetes

Hongyuan Zhang 1, Darren Green 2 and Yanrong Liu 1,3,*
1 Michael Smith Building, Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M20 4BX, UK
2 Vascular Research Group, Department of Renal Medicine, Salford Royal NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
3 The Department of Cardiology, the 1st Affiliated Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China
* Correspondence: yanrong.liu@manchester.ac.uk

Received: 12 October 2023; Revised: 26 November 2023; Accepted: 27 November 2023; Published: 13 February 2025

Abstract: Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). The 2023 European Society of Cardiology (ESC) guidelines represent a significant advancement in the management of CVD in T2DM, building on the 2019 recommendations. Unlike previous iterations, the updated guidelines focus exclusively on T2DM, excluding pre-diabetes due to limited evidence directly linking it to cardiovascular risk. A notable addition is the SCORE2-Diabetes algorithm, which integrates diabetes-specific factors with traditional risk determinants to estimate the 10-year cardiovascular risk. This personalized risk stratification tool underscores the importance of early identification and management of key contributors, such as hyperglycemia and insulin resistance. The guidelines advocate for a multidisciplinary approach, emphasizing collaboration among diabetes, cardiovascular, and chronic kidney disease specialists to address the complex interplay of these conditions effectively. Moreover, the 2023 ESC guidelines highlight the necessity of individualized treatment strategies to reduce cardiovascular complications in T2DM. By reflecting the heterogeneity of diabetic populations and the evolving pharmacological landscape, these recommendations aim to optimize cardiovascular outcomes. This comprehensive update marks a critical step toward reducing the burden of CVD and improving the quality of life for patients with diabetes.
IMPACT OF ISRAELI-HAMAS WAR ON EDUCATION/LEARNING AND LEARNERS’ MENTAL HEALTH IN ISRAEL, GAZA STRIP AND THE USA: A SYSTEMATIC REVIEW OF LITERATURE
Authors: Josephine Oranga  
Published: February 2025

Educators hope that Israel and the Gaza Strip’s experience during the corona-virus pandemic will make the management of education and learning during the current Israeli-Hamas war a little easier as education systems grapple with trauma amongst teachers and learners, on both sides of the divide. It is not clear how long this situation will last, but it definitely means putting on hold the traditional scheduled educational programmes and progress, in most instances, in favour of online and hybrid make-shift educational programmes with the hope that normalcy returns soon. In times of crisis, ideally, the population of learners affected by the crisis need clear directives and frameworks coupled with caring and sensitive teachers and frequent in-person and hybrid meetings amongst teachers and learners to provide re-assurance and hope. Notably, the main dynamic during war is the learners’ constant fear of attacks to them or their families as uncertainty looms large. This fear leads to anxiety, thereby adversely impacting the learners’ mental well-being. This paper, thus, discusses educational situation with regard to Israel, Gaza and to a limited extent, the USA, in light of the latest Israeli–Hamas conflict that began on October the 7th, 2023, following a Hamas attack on Israeli civilians leading to retaliatory attacks from Israel. Accordingly, the main impacts of the war are disruption of education systems and structures, shift to remote learning, psychological trauma and insecurity and fear amongst learners.
ANALYSIS OF FARMERS' INSURANCE LITERACY IN ACEH BESAR DISTRICT, ACEH PROVINCE
Authors: Liston Siringo Ringo  , Hermanto Siregar  , Nunung Kusnadi  , Harianto  
Published: February 2025

Insurance literacy plays a crucial role in expanding farmers' access to insurance. Lack of understanding of insurance products and inability to process information prevent farmers from making the right decisions, which leads to low levels of insurance participation. This study aims to analyze the level of knowledge, attitudes, and behavior of farmers towards insurance and examine the factors that influence farmers' insurance literacy. Data were collected directly from 94 farmer households in four sub-districts in Aceh Besar Regency. This study measured farmers' insurance literacy using a questionnaire and then conducted a regression analysis using the ordinary least squares (OLS) method on variables suspected of influencing insurance literacy. The results of this study indicate that farmers' insurance literacy is sufficient literate. Variables such as gender, age, education level, and main occupation significantly affect farmers' understanding of insurance. The average scores of farmers' knowledge, attitudes, and practices towards insurance were 42.23, 71.36, and 46.28, respectively. Education has a significant impact on farmers' knowledge of insurance. This study suggests that the government and other stakeholders can carry out promotional activities, socialization and training periodically to increase insurance knowledge and awareness.
Számszerűsített Térbeli Modell Rendszer fejlesztése a különböző közlekedési beruházások hatásainak optimalizálása érdekében
Authors: Fütyü István  
Published: February 2025

A kutatás célja a közlekedési munkamegosztás térbeli vizsgálata, annak pozitív befolyásolása és várható hatásainak becslése különböző ösztönzők alkalmazása mellett. A munkamegosztás regionális / körzetek közötti hatékonyabb eloszlása mellett a további cél a modal-shift hasonló alapokon történő térbeli vizsgálata és a különböző multimodalitást ösztönző beavatkozások, valamint az innovatív és kooperatív rendszerek alkalmazásának és hatásainak modellezése. Az intermodalitás EU szinten már régóta fokozott és kitüntetett figyelmet kap, továbbá a technológiai fejlődés eredményeképpen a különböző módszertanok is újra értelmezhetőek, azok könnyebben, hatékonyabban és fokozott hasznossággal alkalmazhatóak. Az EU-s közlekedéspolitikai és klímacélok megvalósulása is jelentős mértékben függ az intermodalitás, és az egyes beruházások optimális alkalmazásától, melyhez a térbeli modell rendszer EU-szintű kiterjesztése további hozzáadott értékkel szolgálhat.
De verbintenisrechtelijke bescherming van de kleine opdrachtnemer
Authors: Sagel S.F. 
Published: February 2025

De verbintenisrechtelijke bescherming van de kleine opdrachtnemer. Bespreking van het proefschrift van mr. N.M.Q. van der Neut
Van der Neut onderzoekt in dit helder geschreven en voor de praktijk uiterst relevante proefschrift welke additionele bescherming een ‘kleine opdrachtnemer’ kan ontlenen aan het verbintenissenrecht, boven op de nogal beknopte wettelijke regeling van de overeenkomst van opdracht. Hij zet die additionele bescherming af tegen de vergaande bescherming die de wet aan de werknemer toekent.
Empowering Consumers through Law?
Authors: van Schagen E.A.G. 
Published: February 2025

Empowering Consumers through Law? Bespreking van het proefschrift van mr. K.E. O’Reilly
Het proefschrift van Kate O’Reilly stelt voor om consumer empowerment te herconceptualiseren. Na een analyse van het concept empowerment en de betekenis daarvan in uiteenlopende vakgebieden, waarbij onderscheid wordt gemaakt in empowerment in vier dimensies, wordt verdedigd om uit te gaan van de ‘disempowered consumer’, dat structureel moet worden gerelateerd aan consumentennadeel. Deze transformatie van het consumentenrecht, waar de huidige gemiddelde consument niet meer het centrale uitgangspunt zou vormen, zou ook niet ten koste moeten gaan van consumentenbescherming, maar hierop moeten voortbouwen.
Afspraken en aanspraken
Authors: Sluysmans J.A.M.A. 
Published: February 2025

Afspraken en aanspraken. Bespreking van het proefschrift van mr. N. van Triet
In haar ambitieuze, actuele en maatschappelijk relevante proefschrift onderzoekt Nikky van Triet in hoeverre ‘afspraken’ met overheden kunnen leiden tot ‘aanspraken’ jegens overheden, enerzijds onder het bestuursrecht en anderzijds onder het civiele recht, welke verschillen op dat vlak tussen beide rechtsgebieden bestaan, en in hoeverre (en hoe) die verschillen kunnen (of moeten) worden overbrugd.
Pelatihan Wl Bagi Remaja Pemuda Sebagai Usaha Keaktifan Dan Keterlibatan Remaja Pemuda Dalam Pelayanan Di GKSI Bacong
Authors: Pingkanita Mese Kasse  
Published: February 2025

Worship leader is a person who is responsible for leading praise in worship sessions. The existence of a worship leader has a very important role in the implementation of worship because almost the entire worship process takes place in the responsibility of the worship leader, not only the person who compiles a series of worship, but is responsible for inspiring the congregation to thank God through song, as well as to enter and enjoy God's presence during the atmosphere of worship or praise and worship God. Thus, whether or not the purpose of worship is achieved depends on the conduct of a worship leader in leading worship. Where a worship leader is needed who is able to bring the atmosphere to truly feel the leading of the Holy Spirit in worship so as to help the preacher to convey what is his part in conveying the truth of God's Word. And young teenagers are the next generation of the church or the backbone of the church. Youth need to be trained as much as possible to take part in church services. And in the ministry, youth have a very important role. Youth ministry determines the future of the Church. However, in GKSI Bacong there are still many young people who are less active and involved in carrying out services in the Church. This PKM aims to facilitate and provide training to young teenagers so that they can be involved and can improve the quality of service in the Church. This PKM was carried out using the training method. During the training, the youth were very enthusiastic and participated in the activities until the end. The youth can understand the material provided. After the PKM is carried out, the teenage youth can apply the material that has been received and carry out with full responsibility and be involved in the service of the Church.
Nordisk tema om mundhygiejne – refleksioner, kommentarer og generelle synspunkter
Authors: Ekstrand Kim , Gussgard Anne M. , Heimisdóttir Lára Hólm , Lingström Peter , Tanner Tarja , Twetman Svante 
Published: February 2025

Klinisk relevans
Dette nordiske tema fokuserer på forskellige aspekter af mundhygiejnens betydning for opretholdelse af oral sundhed. Caries, gingivitis og parodontitis kan kontrolleres ved tiltag over for fælles risikofaktorer. Inden for tandplejen er motiverende samtale den mest anvendte model til adfærdsændring på individniveau. Desuden kan teletandpleje på sigt blive en supplerende strategi til kontrol af caries og parodontale sygdomme. Følgende tiltag kan bidrage til bedre mundhygiejne gennem plakreduktion: grundig tandbørstning med elektrisk eller manuel tandbørste, interdental rengøring med mellemrumsbørster fremfor tandtråd. Fluorid i diverse udgaver modvirker caries ved at reducere progressionshastigheden.
Keramika cetinskog tipa u unutrašnjosti zapadnog Balkana i problem kulturno-istorijske interpretacije praistorijskih nalaza
Authors: Govedarica Blagoje 
Published: February 2025

Cetinska kultura je bez sumnje najznačajnija tekovina ranog bronzanog doba na području istočnog Jadrana i jedna od najautentičnijih kulturnih cjelina u praistoriji zapadnog Balkana uopšte. Najveći broj nalazišta ove kulture koncentrisan je u Dalmaciji i u srednjodalmatinskom zaleđu, te se taj prostor može s pravom smatrati njenom primarnom teritorijom. Otkrivanjei proučavanje Cetinske kulture na tom njenom primarnom prostoru u velikoj mjeri su vezani za ime Ivana Marovića, vrsnog i neumornog istraživača kome smo kao znak osobitog poštovanja nedavno posvetili studiju u kojoj se, takođe, razmatraju pitanja vezana za problematiku odnosa Cetinske kulture i njenog zapadnobalkanskog zaleđa.
Rano srednjovjekovna nekropola Kicelj kod Tuzle
Authors: Bakalović Mirsad 
Published: February 2025

Područje grada Tuzle je zbog svog prirodnog bogatstva - soli, kao i povoljnog prirodno-geografskog položaja, još u prethistorijskom dobu privlačilo čovjeka da se na njemu trajno nastani. 0 tome govore brojni otkriveni arheološki nalazi u samoj Tuzli, kao i njenoj bližoj i daljoj okolini. Arheološki ostaci pripadaju raznim vremenskim periodima: prethistorija, antika, srednji vijek. Svakako najznačajnija su neolitska nalazišta u Gornjoj Tuzli i strogom centru grada Tuzle. U Gornjoj Tuzli otkriveno je najstarije neolitsko naselje u Bosni i Hercegovini, a u Tuzli jedno od najvećih i najstarijih neolitskih sojeničkih naselja u jugoistočnoj Evropi. Za oba naselja veže se prvobitna proizvodnja soli, koja kao i kontinuitet života, traje sve do danas. U aprilu 1992. godine, prilikom kopanja rovova za odbranu grada Tuzle od neprijateljske agresije na Bosnu i Hercegovinu, na brdu Kicelj, koje se uzdiže iznad centra grada, otkrivena je nekropola. Tom prilikom, zbog ratnih dejstava, dio grobova je oštećen, a samo otkriće nekropole nije prijavljeno, već je i zaboravljeno. Kako je vrijeme odmicalo, zahvaljujući atmosferlijama i pojavi klizišta na lokalitetu Kicelj, u profilu iskopanih rovova pojavili su se ostaci skeleta. Ti ostaci su zainteresovali Tahira Abdulića, koji živi neposredno uz nekropolu, da otkopa jedan od grobova i tom prilikom uz skelet je pronašao i dva para bronzanih naušnica. Gospodin Abdulić je naušnice predao Mirzi Mukiću, novinaru lista Front Slobode, a on ih je ustupio Muzeju istočne Bosne Tuzla.