bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of Microbiome in Personalized Medicine
Authors: Siraj Sami 
Published: May 2024

The human microbiome, which consists of trillions of microorganisms residing in and on the human body, plays a significant role in personalized medicine. The microbiome has been recognized as a critical factor influencing various aspects of health and disease, and its consideration in personalized medicine is expanding. Factors such as genetics, diet, environment, and lifestyle contribute to the unique microbial profile of each person. Therefore, the microbiome varies between individuals in terms of its composition and diversity.
The microbiome can influence drug metabolism and response. Some drugs undergo biotransformation by gut bacteria, affecting the pharmacokinetics and efficacy of the drugs. Understanding an individual's microbiome may help predict and optimize drug responses. The microbiome also plays a crucial role in shaping the immune system. Imbalances or dysbiosis in the microbiome have been linked to various immune-related disorders. Considering the microbiome in the development of immunotherapies and treatments for autoimmune diseases would help in developing personalized medicine.
The bidirectional communication between the gut and the brain, known as the gut-brain axis, is influenced by the microbiome. The gut microbiome may impact neurological conditions, mental health, and even responses to certain medications. Personalized approaches may consider the gut-brain axis in neurological and psychiatric disorders. Similarly, alterations in the microbiome have been associated with various diseases, including inflammatory bowel disease, obesity, diabetes, and cancer.
An individual's unique microbiome is crucial when designing personalized dietary recommendations. The microbiome influences metabolism, nutrient absorption, and overall health. Microbial biomarkers are being explored for disease diagnosis, prognosis, and treatment response. The identification of specific microbial signatures associated with certain conditions may aid in personalized diagnostics and treatment planning.
Personalized medicine can help develop microbiome-targeted therapies, such as fecal microbiota transplantation or probiotics, to restore a healthy microbial balance in individuals with dysbiosis-related conditions. Computational models that integrate genetic, clinical, and microbiome data can be used to predict an individual's susceptibility to certain diseases or response to specific treatments. These models contribute to more precise and individualized medical care.
The microbiome is an integral component of personalized medicine, influencing drug responses, immune function, and disease risk. Integrating microbiome data into personalized healthcare approaches has the potential to enhance diagnostic accuracy, treatment efficacy, and overall health outcomes for individuals. However, several challenges remain including the complexity of microbial interactions and the need for standardized methodologies. Ethical considerations, including privacy issues related to microbiome data, also need attention in the context of personalized medicine.
Pharmacogenomic Variants Affecting Statins Response in Sri Lanka
Authors: Staff Editorial 
Published: May 2024

Pharmacogenomic variants can influence the efficacy and toxicity of statins, which are commonly prescribed medications for managing cholesterol levels and reducing the risk of cardiovascular events. Statins work by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis. Ranasinghe and colleagues investigated the diversity of pharmacogenetic variants of statins among Sri Lankans. They compared the minor allele frequencies (MAFs) of 426 Sri Lankans with other populations. They observed the following MAFs in common genes usually associated with statins response and toxicity. The MAF of SLCO1B1*5 (rs4149056 [T>C]) was 18.19% (95% CI: 14.53-21.85), MAFs of CYP2C9*2 (rs1799853 [C>T]) and CYP2C9*3 (rs1057910 [A>C]) were 2.58% (95% CI: 1.08-4.08) and 10.30% (95% CI: 7.75-13.61), respectively, MAFs of rs2231142 (G>T) (ABCG2), rs7412 (C>T) (APOE) and rs20455 (A>G) (KIF6) variants were 10.68% (95% CI: 7.76-13.60), 3.52% (95% CI: 1.77-5.27) and 50.7% (95% CI: 45.96-55.45), respectively. They found the frequency of two variants higher in the Sri Lankan population compared to the Western and other Asian populations (rs20455 (A>G), CYP2C9*3 (A>C) and SLCO1B1*5 (T>C)). They concluded that genetic polymorphisms affecting efficacy of statins (KIF6 [rs20455], CYP2C9*3) and increased risk of statin-induced myotoxicity (SLCO1B1*5 and CYP2C9*3) were prevalent in higher frequencies among Sri Lankans compared with Western populations. Pharmacogenomics. 2023 Oct;24(15):809-819. doi: 10.2217/pgs-2023-0149.
Melissa Officinalis and Essential Hypertension
Authors: Editorial Staff  
Published: May 2024

For long plants and herbs have been used to treat cardiovascular diseases and Melissa officinalis (M. officinalis) Is one of those plants. However, there is no conclusive evidence for the effects of the plant on both systolic and diastolic blood pressures in hypertensive patients. Shekarriz and colleagues performed a double-blind cross-over clinical trial with 49 hypertensive patients given either placebo or capsules of the plant (400mg/d) thrice a day for a week. The blood pressure was measured at baseline once and then biweekly for 2.5 months. Their findings revealed that both systolic and diastolic blood pressures were reduced in patients given M. officinalis compared to the placebo. Moreover, no drastic adverse effects were observed. Hence, they conclude that in patients with primary hypertension, both systolic and diastolic blood pressures can be significantly decreased by M. officinalis. Phytother Res. 2021 Dec;35(12):6883-6892.
Activation of Wnt/β-Catenin Pathway by Icarisid II Improves Cognition
Authors: Editorial Staff  
Published: May 2024

Reestablishing the impaired neurogenesis in Alzheimer’s disease (AD) patients can lead to improved cognitive function. Xiao and colleagues investigated whether the natural product icarisid II (ICS II) which possesses strong neuroprotective properties can restore physiological neurogenesis in APP/PS1 mice. After oral administration of ICS II, APP/PS1 mice showed hippocampal neuronal generation alongside the activation Wnt/β-catenin signal pathway as exhibited by the stimulation of Wnt-3a, phosphorylated glycogen synthase kinase-3β (p-GSK-3β) and β-catenin. Their data also showed inhibition of phosphorylated dynamin-related protein 1 (p-Drp), mitochondrial fission factor (Mff), and mitochondrial fission 1 protein (Fis1). However, upregulation of Mitofusin 1 (Mfn 1) and Mitofusin (Mfn 2) suggested a depression in mitochondrial fission. These effects of ICS II were canceled by XAV-939. a Wnt/β-catenin signaling pathway inhibitor. The authors concluded that ICS II can mitigate mitochondrial fission through the Wnt/β-catenin pathway and alleviate cognitive damage through neurogenesis in an AD mouse model. Phytother Res. 2022 May;36(5):2095-2108.
Amelioration of Liver Fibrosis by Pharbitis nil Through TGFβ1-SMAD2/3 Pathway
Authors: Editorial Staff  
Published: May 2024

In the regions of Eastern Asia, traditional remedies of the seeds of the medicinal herb Choisy, scientifically known as Pharbitis nil (L.) have been used to treat hepatic diseases such as cirrhosis of the liver, fatty liver, and obesity. In chronic inflammatory hepatic disorders such as non-alcoholic steatohepatitis, fibrosis of the liver is the leading cause of morbidity and mortality. However, efficacious pharmaceutical products to treat liver fibrosis are awaiting approval. Jung and colleagues investigated whether alleviation of hepatic fibrosis is possible with Pharbitis nil ethanolic extract (PNE). Two different pre-clinical models were used in this investigation. C57BL/6 male mice that were 6 weeks old were given CCl4 as intraperitoneal injections two times a week for 6 weeks after which they were subjected to daily administration of 5 or 10 mg/kg PNE from the third week onwards. For 41 weeks the mice were given a high-fat diet (HFD) and at week 35 they were given 5mg/kg PNE every day for the final 6 weeks. The antifibrotic effects of PNE were further evaluated in primary mouse hepatic stellate cells and LX-2 cells. In both CCl4-treated mice and mice subjected to HFD, PNE successfully mitigated liver fibrosis, inflammation, and hepatic necrosis as well as inhibited the liver fibrosis progression. Reduced levels of fibrosis markers such as SMAD2/3 activations in mouse livers and in TGFβ1-treated primary mouse hepatic stellate and LX-2 cells show that PNE attenuates liver fibrosis by downregulating TGFβ1-induced SMAD2/3 activation. J Ethnopharmacol. 2022 Aug 10;294:115370.
Artemisia Argyi Extract Uses PI3K/MAPK Signaling to Induce Apoptosis in Human Gemcitabine-Resistant Lung Cancer Cells
Authors: Editorial Staff  
Published: May 2024

Artemisia argyi H. Lév. & Vaniot (Asteraceae), also called "Chinese mugwort,” is frequently used as a herbal medicine in China, Japan, Korea, and eastern parts of Russia. It is termed “ai ye” and “Gaiyou” in China and Japan, respectively. It was an ancient Chinese practice that before Tomb-sweeping day, the leaves of A. argyi be consumed. Renal and Hepatic pathologies and conditions such as hepatitis, asthma, sinusitis, irregular menstrual cycles, and inflammatory syndromes were all treated by this plant. Although A. argyi extract (AAE) has demonstrated antineoplastic potential, the mechanisms by which this is achieved in lung cancer are yet to be known. Su et al. used CL1-0 parent and gemcitabine-resistant (CL1-0-GR) lung cancer cells to investigate the underlying mechanisms of AAE’s anti-tumor effects. In CL1-0 and CL1-0-GR cells, a significantly decreased cell viability and induction of apoptosis were observed after AAE treatment. AAE-induced apoptosis was found to be regulated via the PI3K/AKT, and MAPK signaling pathways. AAE also prevented CL1-0 and CL1-0-GR cancer cell invasion, migration, colony formation, and spheroid formation. In addition, AAE acted cooperatively with commercial chemotherapy drugs to enhance tumor spheroid shrinkage. Their study provides the first evidence that A. argyi treatment suppresses both parent and gemcitabine-resistant lung cancer cells by inducing ROS, mitochondrial membrane depolarization, and apoptosis. Their findings provide insights into the anti-cancer activity of A. argyi and suggest that the plant may serve as a chemotherapy adjuvant that potentiates the efficacy of chemotherapeutic agents. J Ethnopharmacol (2022) DOI: 10.1016/j.jep.2022.115658.
Editor's Summaries of the Articles Published in This Issue of Phytopharmacological Communications
Authors: Editorial Staff  
Published: May 2024

In this issue, Afzal and colleagues investigated the diuretic potential of diosmetin, a flavonoid from Citrus lemon, in the Sprague-Dawley rat model; Hafsa et al. reviewed natural remedies for gout and highlighted the importance of medicinal plants as a safe alternative to current conventional therapies against gout, Saghir and colleagues investigated the antispasmodic and antidiarrheal effect of Hippeastrum puniceum and elucidated their mechanism of action, Naseer et al., investigated, n-hexane fraction of Conyza bonariensis's (CB) for its cytotoxic property, Jahanabadi and colleagues compiled and reviewed the medicinal plants with anti-colic activities, while Ahmed and Zahid reviewed and discussed natural remedies for the treatment of diabetes Mellitus.
Kaempferol Promotes Lung Cancer Cell Autophagy
Authors: Staff Editorial 
Published: May 2024

Autophagy is a cellular process involved in the degradation and recycling of cellular components, and it plays a complex role in cancer. In the context of lung cancer, including lung cell cancer, the relationship between autophagy and cancer is multifaceted and can vary depending on the specific circumstances. Wang and colleagues investigated the molecular mechanism by which kaempferol (from Hedyotis diffusa) promotes autophagy in Non-Small Cell Lung Carcinoma (NSCLC) cells. Their results suggest that kaempferol significantly inhibits NSCLC cell proliferation. Kaempferol also caused NSCLC cell death by promoting NSCLC cell autophagy. Their experiments reveal that both protein and mRNA expression of Met was significantly inhibited. They also observed the inhibition of PI3K/AKT/mTOR signaling pathway. These results were validated by the overexpression of Met which resulted in the reversal of kaempferol effects on NSCLC cell viability and cell autophagy. They concluded that Kaempferol exerts its anti-NSCLC effect by promoting NSCLC cell autophagy which involves Met and its downstream PI3K/AKT/mTOR signaling pathway. Phytomedicine. 2023 Dec:121:155090. doi: 10.1016/j.phymed.2023.155090.
Pengaruh Kualitas Produk dan Promosi Terhadap Keputusan Pembelian Handphone VIVO di Transcom Gunungsitoli
Authors: Zendrato Erna Kristiani , Laia Otanius , Waruwu Meiman Hidayat , Mendrofa Yupiter 
Published: May 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Kualitas Produk Dan Promosi Terhadap Keputusan Pembelian Hp Vivo Di Transcom Gunungsitoli.Penelitian ini menggunakan 3 Variabel yaitu Kualitas Produk (X1), Promosi (X2) dan Keputusan Pembelian (Y) dengan Sumber data yaitu data Primer dengan teknik pengumpulan data melalui Kuesioner dengan ukuran Sampel 30 Responden. Jenis Penelitian yang digunakan dalam penelitian ini adalah Penelitian Kuantitatif, dari hasil penelitian maka disimpulkan bahwa hasil perhitungan Uji Validitas butur item angket variabel Kualitas Produk (X1) dan Variabel Promosi (X2) didapatkan bahwa memenuhi syarat validasi karena, dengan jumlah sampel sebanyak 30 dan sig.2-tailed 0,05 maka diperoleh nilai r tabel sebesar 0,361 dan berdasarkan table pengolahan spss diatas. Nilai r hitung setiap data kuesioner lebih besar dari 0,362, sehinggha dapat di katan bahwa data kuesioner valid dan hasil perhitung uji validitas butir item angket variabel keputusan pembelian (Y) didapatkan bahwa memenuji syarat validasi karena berdasarkan hasil penelitian r-hitung seluruh butir pertanyaan memiliki nilai lebih besar dari r-tabel sebesar, 0,361 (r-hitung>r-tabel), sehingga di nyatakan Valid.
Wearable: ¿Lujo o Necesidad?
Authors: Pinzon Rios Ivan Dario 
Published: May 2024

Se realizó un análisis reflexivo de artículos originales en inglés, portugués y español disponible 2013-2023 sin restricción de edad o género, que mencionen la definición, usos e implicaciones de los sensores portátiles o wearables (SP-W) en Fisioterapia. Se obtuvo una muestra total de 350 artículos, luego de la lectura y análisis de los títulos y resúmenes, se seleccionaron 56 bibliografías. Se pudo concluir que los SP-W son una necesidad real que el fisioterapeuta tiene al alcance para poder evaluar, intervenir y monitorizar diversas poblaciones con o sin alteraciones del movimiento y se vislumbran como un futuro cerca en el quehacer de este profesional, llevándolo a estar a la vanguardia con las nuevas tecnologías
Peningkatan Pengetahuan Kesehatan Reproduksi pada Lansia Pre-Menopause di Desa Taraweang Kabupaten Pangkep
Authors: Kasim Jamila , Firawati Firawati 
Published: May 2024

Tujuan Pengabdian Kepada Masyarakat ini untuk meningkatkan pengetahuan pada masyarakat khusunya ibu-ibu lansia dengan kisaran usia 40-55 Tahun di desa taraweang dalam menghadapi Pre-Menopause, cara paling mudah dengan dilakukan pendidkan kesehatan melalui penyuluhan, agar itulah maka dilakukan kegiatan pengabdian yang di harapkan meningkatkan pengetahuan masyarakat tentang kesehatan reproduksi lansia pre-menopause sehingga dapat mencegah beberapa hal yang tidak diinginkan, salah satunya gangguan fisik dan psikis, Metode pelaksanaan Pengabdian ini menggunakan ceramah dan diskusi, materi yang diberikan yakni Proses Biologis, Menopause , Proses Menopause ,Gejala Menopause, Perubahan dan gejala timbul saat menopause, Persiapan diri menghadapi menopause, Seksualitas Pada Wanita Menopause, hasil evaluasi pengabdian pre test dan post test, peserta menunjukkan peningkatan pengetahuan terhadap materi yang diberikan.

Kata Kunci : Pengetahuan, Kesehatan Reproduksi Lansia , Pre-Manopause
การดำเนินนโยบายการต่างประเทศของสหรัฐอเมริกาต่อเวียดนามตั้งเเต่ยุคโอบามาจนถึงต้นยุค โจ ไบเดน
Authors:   , โพลงพันธ์ ณัฐนันท์ 
Published: May 2024

สารนิพนธ์ฉบับนี้มุ่งศึกษาความสัมพันธ์ระหว่างสหรัฐอเมริกากับสาธารณรัฐสังคมนิยมเวียดนามตั้งแต่ยุคบริหารของประธานาธิบดี บารัค โอบามา จนถึงยุคประธานาธิบดี โจ ไบเดน เพื่อทำความเข้าใจเหตุผลว่าทำไมสหรัฐฯ ถึงให้ความสำคัญกับเวียดนาม โดยมุ่งตอบคำถามว่าแต่ละยุคสมัยนั้นการดำเนินนโยบายการต่างประเทศของสหรัฐฯ ต่อเวียดนามมีความต่อเนื่องและต่างกันอย่างไร โดยใช้แนวคิด partnership – alliance เป็นกรอบการวิเคราะห์ เพื่อเสนอจุดยืนว่า ทั้งสามนโยบาย Pivot to Asia, Free and Open Indo-Pacific และ Indo-Pacific Strategy ของสามยุคสมัยประธานาธิบดีสหรัฐฯ โอบามา ทรัมป์ และโจ ไบเดน มีวัตถุประสงค์หลักที่ต่อเนื่องกันคือการคานการผงาดขึ้นมาของจีนที่เป็นมหาอำนาจใหม่ที่กำลังท้าทายสถานภาพของสหรัฐอเมริกาในภูมิภาคเอเชียตะวันออกเฉียงใต้และคงไว้สถานะมหาอำนาจของสหรัฐฯ โดยเน้นส่งเสริมด้านเศรษฐกิจและ ความมั่นคง แต่แตกต่างกันตรงที่วิธีการดำเนินนโยบายต่อเวียดนามจะปรับตามแนวคิดของแต่ละยุคประธานาธิบดี
Caesarean Section Trend in a Selected Hospital between 2014 And 2019: Observational Study
Authors: Al–Asabe Qaid Hasan Ali , Al-Haddad Ahmed Mohammed , Al-Emad Adel Ahmed 
Published: May 2024

Caesarean section is a life-saving surgical procedure that can prevent complications and mortality of maternal and new-born when used for clinically indicated reasons. this study aimed to describe trends in caesarean section in private hospital under study from 2014 to 2019 Sana’a, Yemen. This study conducted as a retrospective observational study, The study population was all pregnant women admitted to labour room and gave birth between March 2014 and September 2019, and used secondary data on defined period, for 3,740 pregnant women admitted to labour room and gave birth by vaginal delivery or caesarean section. The data were analysed using Microsoft Excel and IBM SPSS Statistics software version 26.0. The results of this study found that the total mean of CS rate for period of 2014 to 2019 was 65% of total deliveries, the associated factor with the caesarean section was the maternal age (P-value <,000). Also, there was a significant relationship exists between Length of Stay and mode of delivery across various age groups. Further, studies are recommended to identify determinants, indications of CS and nonclinical factors, affecting CS rate in the same hospital and others.
Unilateral Vocal Fold Paralysis in Adults: Etiological Factors in Yemen
Authors: Muthanna Ali Obaid 
Published: May 2024

Background: Unilateral vocal fold paralysis is common finding in otolaryngology practice. It is not a diagnosis by itself. The exact incidence of unilateral vocal fold paralysis has been difficult to find out because of multiple reasons. Various etiologies known to cause this condition are neck surgery, cancer, neck trauma, and neurological disorders.
Objective: The aim of this study was to determine the possible etiologies of unilateral vocal fold paralysis in adult patients.
Methods: A hospital-based study was conducted at OtoLaryngology Department, Al-Thawra Teaching Hospital, Sana'a, Yemen, between January 2014-June 2018. Patients have unilateral vocal fold paralysis were enrolling in this study. All patients underwent to history, clinical examination, laboratory investigations, and radiological studies, X- ray, CT, MRI).
Results: A total of 80 patients with unilateral vocal fold paralysis, males59 (73.6%), females 21(26.4%). Age ranged from18-80 years, mean age 51.5years Left vocal fold paralysis (72.5%), while right side was (27.5%). Peripheral causes (93.7%). Idiopathic (32.5%), malignancy (31.2%), trauma (21.2%), TB (7.5%), while central causes were (6.3%), and Guillain Barre (GB) syndrome (1.3%).
Conclusion: Left vocal fold paralysis was the most common finding. Idiopathic was the most common cause, flowed by malignancies and trauma. Thyroidectomy continues to be the single most surgical procedures responsible for unilateral vocal fold paralysis. For this reason, pre and post thyroidectomy laryngoscopy should be considered in all patients undergoing thyroid surgeries
PENGUJIAN MUTU FISIK FORMULASI SEDIAAN SABUN PADAT BERBAHAN SUSU KEDELAI
Authors: Sanjiwani Ni Made Sukma Sanjiwani , Ni Nyoman Yudianti Mendra  , Agus Sudharmayasa  
Published: May 2024

Soap is a product formed through the reaction between fatty acids and strong bases, which has a function as a dirt cleaner. Soap containing Sodium Lauryl Sulfate (SLS) can cause irritation for users with sensitive skin types. The use of natural ingredients is highly considered to minimize the side effects of using synthetics. Soy milk is one of the natural ingredients that can be utilized because it contains antioxidant compounds that are beneficial to ward off free radicals on the skin. Soy milk also contains saponin compounds, a natural ingredient used as a soap foaming agent that is more environmentally friendly than chemicals. This study aims to evaluate the physical quality of soy milk solid soap dosage formulations. In this study, four soap formulas were made with variations in soy milk concentrations of 11, 15 and 19%. The physical quality test parameters included organoleptic test, homogeneity test, pH test, and foam height test. The research data was analyzed with SPSS version 25 with the Kruskal-Wallis test with a confidence level of 95%. Based on the results of the study, soy milk solid soap was obtained with good physical quality including organoleptic, homogeneity and foam height. However, the pH value of soy milk solid soap does not comply with the provisions imposed for soap products.
Nutrient management for enhancing productivity of pigeonpea (Cajanus cajan) based intercropping system under rainfed condition
Authors: I.B. PANDEY  , S. TIWARI  
Published: May 2024

A field experiment was conducted during the rainy (kharif) season of 2011–12 and 2012–13 at Tirhut College of Agriculture, Dholi, Bihar, to study the effect of nutrient management for enhancing productivity of pigeonpea [Cajanus cajan (L.) Millsp.]-based intercropping systems. Pigeonpea + turmeric (Curcuma longa L.) intercropping system, recorded significantly higher pigeonpea yield (2.00 t/ha), pigeonpea-equivalent yield (4.79 t/ha), fruiting efficiency (18.8%), water-use efficiency (6.1 kg grain/ha/mm), production efficiency (18.0 kg/ha/day) and net re turns ( 106.32 ×10/ha) than pigeonpea + maize (Zea mays L.) intercropping and sole pigeonpea. However, pigeonpea + turmeric recorded lower benefit: cost (B: C) ratio than sole pigeonpea. Significantly higher B: C ratio was recorded under pigeonpea + sesame (Sesamum indicum L.) (2.32) and pigeonpea + urdbean [Vigna mungo (L.) Hepper] (2.31) intercropping systems than pigeonpea + maize, pigeonpea + turmeric and sole pigeonpea. Pigeonpea + maize recorded significantly lower NPK uptake by pigeonpea than sole pigeonpea and the other in tercropping systems. Pigeonpea + mungbean [Vigna radiata (L.) R. Wilczek] and pigeonpea + urdbean recorded significantly higher number and dry weight of nodules /plant than pigeonpea + maize. Application of 125% recom mended dose of fertilizer (RDF) recorded significantly higher number of branches and pods/plant, pigeonpea equivalent yield (3.39 t/ha), land-equivalent ratio (1.87), production efficiency (12.8 kg/ha/day), net returns ( 80.83 ×103/ha), benefit: cost ratio (2.17) and NPK uptake by pigeonpea than RDF and 75% RDF. Pigeonpea equivalent yield in pigeonpea + urdbean, pigeonpea + mungbean and pigeonpea + sesame intercropping sys tems, increased significantly with the increasing levels of fertilizer up to RDF, and further increase in fertilizer level did not show significant effect on pigeonpea-equivalent yield. However, it increased significantly up to 125% RDF in pigeonpea + maize and pigeonpea + turmeric intercropping systems. Pigeonpea + urdbean and pigeonpea + mungbean increased organic carbon, available N, P, K content of the soil than the other intercropping systems and initial soil value.