bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lagrangian subbundles of symplectic bundles over a curve
Authors: CHOE INSONG , HITCHING GEORGE H. 
Published: February 2012

AbstractA symplectic bundle over an algebraic curve has a natural invariantsLagdetermined by the maximal degree of its Lagrangian subbundles. This can be viewed as a generalization of the classical Segre invariants of a vector bundle. We give a sharp upper bound onsLagwhich is analogous to the Hirschowitz bound on the classical Segre invariants. Furthermore, we study the stratifications induced bysLagon moduli spaces of symplectic bundles, and get a full picture for the case of rank four.
On the set of zero coefficients of a function satisfying a linear differential equation
Authors: BELL JASON P. , BURRIS STANLEY N. , YEATS KAREN 
Published: February 2012

AbstractLetKbe a field of characteristic zero and suppose thatf:→Ksatisfies a recurrence of the form\[ f(n) = \sum_{i=1}^d P_i(n) f(n-i), \]fornsufficiently large, whereP1(z),. . .,Pd(z) are polynomials inK[z]. Given thatPd(z) is a nonzero constant polynomial, we show that the set ofn∈for whichf(n) = 0 is a union of finitely many arithmetic progressions and a finite set. This generalizes the Skolem–Mahler–Lech theorem, which assumes thatf(n) satisfies a linear recurrence. We discuss examples and connections to the set of zero coefficients of a power series satisfying a homogeneous linear differential equation with rational function coefficients.
The manifestation of transference during early psychotherapy sessions: Exploring an alternate data source for therapist narratives in transference research
Authors: Jaffee Catherine Tellides , Fitzpatrick Marilyn , Drapeau Martin , Bracewell Robert , Chamodraka Martha , Marini Nadia 
Published: February 2012

AbstractIntroduction: Previous transference studies have compared in‐session client narratives about significant others to in‐session client narratives about the therapist, limiting data to the information that clients are willing to share with the therapist. Method: The first three sessions of 30 therapies with high‐functioning individuals were examined using the Core Conflictual Relationship Theme (CCRT) method. Client narratives about others were drawn from the psychotherapy sessions and client narratives about the therapist were drawn from a Participant Critical Event (PCE) interview conducted after the third session of therapy. Results: Factor analyses of the CCRT components indicated several relational patterns: a complementary pattern of relating characterised by a devaluation of the therapist and idealisation of others; a concordant relational transfer where clients feel bad with both the therapist and others; and as clients experience control issues with significant others, they wish to adopt a submissive stance toward the therapist. The results suggest that the source of therapist narratives may influence the results of transference research.
Photo-induced currents in CdZnTe crystals as a function of illumination wavelength
Authors: Teague L C , A L Washington , Duff M C , Groza M , Buliga V , Burger A 
Published: February 2012

Abstract
We report variations in the currents of CdZnTe semiconductor crystals during exposure to a series of light emitting diodes of various wavelengths ranging from 470 to 950 nm. The changes in the steady-state current of one CdZnTe crystal with and without illumination along with the time dependence of the illumination effects are discussed. Analysis of the de-trapping and transient bulk currents during and after optical excitation yield insight into the behaviour of charge traps within the crystal. Similar behaviour is observed for illumination of a second CdZnTe crystal suggesting that the overall illumination effects are not crystal dependent.
A new approach for improving the silicon texturing process using gas-lift effect
Authors: Amouzgar M , Kahrizi M 
Published: February 2012

Abstract
A new cost-effective and efficient approach is proposed for texturing the crystalline silicon using the gas-lift effect (GLE). The advantages of this approach over the conventional ones are that significantly lower amounts of IPA is used and much shorter etching time is required to achieve the same reflectivity. GLE is generated by taking advantage of the hydrogen bubbles evolved between the silicon wafer being etched and a glass plate, placed in parallel, creating a gap of 1–2 mm. This effect then acts as a pumping mechanism detaching more bubbles from the silicon surface, accelerating them to the top and out of the system, as quickly as they are generated. Experiments were carried out with various combinations of TMAH/IPA concentrations for two different GLE conditions to analyse and determine their influence on etching time, etching rate, surface morphology and reflectivity of the textured silicon surface. The use of this new approach in surface texturing, allowed the reduction of the required IPA by 50% and etching time by more than 60% to achieve the same reflectivity. This can ultimately lead to a significant reduction in cost by increasing the efficiency of the texturing process. A combination of 3.5% IPA and 2 mm GLE resulted in a textured silicon surface having a low specular solar-weighted reflectivity of 0.15%.
TiO2 coatings with Au nanoparticles analysed by photothermal IR radiometry
Authors: Macedo F , Vaz F , Torrell M , Faria R T , Cavaleiro A , Barradas N P , Alves E , Junge K H , Bein B K 
Published: February 2012

Abstract
Optically active Au : TiO2 nanocomposite thin films with an amount of gold of about 15 at% were prepared by dc reactive magnetron sputtering. After the deposition, the samples were annealed in vacuum at different constant temperatures between 200 and 800 °C. Depending on the annealing temperature, considerable changes have been found in the films' crystalline structure and for the number, the shape and the dimensions of the Au clusters. Modulated IR Radiometry (MIRR), a non-contact, non-destructive modulation-frequency-dependent photothermal measurement technique, was used for the characterization of the thermo-optical depth profiles of the as-deposited and annealed samples. Based on the results of MIRR, it was possible to establish correlations of the measured thermo-optical depth profiles with various effects: the heat treatment induced progress of crystallization of the TiO2 matrix, the evolution of Au nanoparticles and strong subsurface heat sources related to the surface plasmon resonance (SPR) effect. For the annealing temperature of 800 °C, a diffusion and accumulation of gold just at the surface was found, which contributes to limit the subsurface heat sources and the SPR effect.
Changes and trends in the demersal fish community of the Flemish Cap, Northwest Atlantic, in the period 1988–2008
Authors: Pérez-Rodríguez Alfonso , Koen-Alonso Mariano , Saborido-Rey Fran 
Published: February 2012

Abstract
Pérez-Rodríguez, A., Koen-Alonso, M., and Saborido-Rey, F. 2012. Changes and trends in the demersal fish community of the Flemish Cap, Northwest Atlantic, in the period 1988–2008. – ICES Journal of Marine Science, 69: 902–912. The Flemish Cap fish community (NAFO Division 3M) has been fished since the 1950s, and major changes in the biomass and abundance of its most important commercial species have been reported since the late 1980s. Variations in oceanographic conditions at the Cap, with alternating periods of cold and warm weather, have also been described. This work examines the existence of common trends in the biomass levels of the main demersal species over time using dynamic factor analysis, and the occurrence of “occasional species” was explored in relation to temperature conditions. Overall, there have been significant changes in community structure involving both commercial and non-commercial species. Common trends among species were identified and overall fishing pressure, environmental conditions (represented by a moving average of the North Atlantic Oscillation, NAO), and predation pressure (represented by the abundance of piscivorous fish) emerged as important drivers of the temporal dynamics. The NAO influence in the dynamics of most species was in agreement with their temperature preference. For occasional species, their pattern of occurrence appears also to be linked to changes in temperature regimes.
Muscle-Specific Kinase-Antibody-Positive Myasthenia Gravis After Autologous Bone Marrow Transplantation
Authors: Grover Kavita Mohindra , Sripathi Naganand , Elias Stanton Bernard 
Published: February 2012

Abstract
A 44-year-old man presented with oculobulbar weakness approximately 5 years after autologous bone marrow transplantation (BMT). His workup led to the diagnosis of muscle-specific kinase-antibody-related myasthenia gravis (MG). There has been only one case report of muscle-specific kinase-antibody-positive MG after BMT, which was allogeneic. We report the first case of autologous BMT-associated MG with muscle-specific kinase antibody. The pathogenic mechanisms of immune dysregulation leading to MG after BMT are discussed.
Outcome Prediction Value of Nerve Conduction Studies for Endoscopic Carpal Tunnel Surgery
Authors: Lo Yew-Long , Lim Shu-Han , Fook-Chong Stephanie , Lum Sau-Ying , Teoh Lam-Chuan , Yong Fook-Chuan 
Published: February 2012

Objective
Carpal tunnel syndrome is the most common entrapment neuropathy. We explore the clinical use of nerve conduction study in the outcome prediction and preoperative selection for endoscopic carpal tunnel syndrome surgery.

Methods
Sixty-seven patients with carpal tunnel syndrome were prospectively enrolled. Each patient's clinical symptomatic score at baseline and 3 months postsurgery was compared with nerve conduction study parameters of distal motor latency, motor amplitude, motor conduction velocity, distal sensory latency, sensory amplitude, and sensory conduction velocity. A statistical logistic regression model was used to ascertain outcomes.

Results
Endoscopic surgery resulted in significant improvement for all four major symptoms pain, numbness, paresthesia, and weakness. From multivariate logistic regression, a shorter distal sensory latency is associated with a higher likelihood of a good outcome (P = 0.058; odds ratio, 0.912; 95% confidence interval, 0.828–1.0) only for paresthesia. The other factors were not found to be significant (all P > 0.10). The area under the curve (AUC) was 0.69 (95% confidence interval for AUC, 0.50–0.88). A cutoff of 6.0 ms or lower for sensory latency predicts for good outcome (in terms of paresthesia score) with the sensitivity/certainty of 84.6% and positive predictive value of 86.8%. A receiver operating characteristic analysis of baseline paresthesia score for good outcome of the paraesthesia domain showed that the AUC was 0.967 (95% confidence interval for AUC, 0–1.0). At a cutoff of baseline paraesthesia score of 4 or above, prediction for good outcome achieved a sensitivity of 87.2% and positive predictive value of 97.1%.

Conclusions
A shorter distal sensory latency is associated with a higher likelihood of a good outcome for paraesthesia. In addition, patients with baseline of 4 or above had correlated with better surgical outcome than those with less severe symptoms. Our data thus suggest that surgical benefit is best seen in patients with moderate symptoms, in combination with electrophysiological evidence of early demyelination, as a possible therapeutic window.
Muscle Restricted Vasculitis Causing Dropped Head Syndrome
Authors: Nielsen Amy Almaraz , Smith Benn E. , Engel Andrew G. , Bosch Erich Peter 
Published: February 2012

Abstract
A 52-year-old man presented with a severe head drop and proximal extremity weakness. Magnetic resonance imaging of the cervical spine showed T2 hyperintensity in cervical paraspinal muscles. Electrodiagnostic studies revealed an axial myopathy isolated to paraspinal muscles. A splenius capitis muscle biopsy confirmed an acute myopathy associated with nonsystemic vasculitis. The patient improved on steroids, intravenous immunoglobulin, and monthly pulse doses of cyclophosphamide. Our case emphasizes that a subgroup of patients with dropped head syndrome have treatable conditions.
Current understanding of human genetics and genetic analysis of psoriasis
Authors: OKA Akira , MABUCHI Tomotaka , OZAWA Akira , INOKO Hidetoshi 
Published: February 2012

AbstractDuring the past 5 years, genome‐wide association studies (GWAS), primarily based on single nucleotide polymorphism markers, have identified many loci as potential psoriasis susceptibility regions. These studies appeared to provide strong evidence because the susceptibility genes are involved in the interleukin‐23/T‐helper 17 axis of psoriasis immunopathogenesis and/or skin barrier functions. However, the “identified” genes only explained a small proportion of psoriasis heritability, although it is known to be comparatively higher than that of other common diseases. GWAS are based on the hypothesis that disease‐causing variants are high frequency variants within populations. However, this hypothesis is problematic because deleterious variants such as those predisposing to specific diseases will generally not be maintained by selection pressure throughout human evolution. This issue also affects psoriasis studies. Here, we review the current paradigm shift in human genetic analyses and its implications for detection of psoriasis‐causing variants based on linkage analysis and GWAS, except the well‐known psoriasis susceptibility locus HLA‐C.
Association of adiponectin with blood pressure in healthy people
Authors: Baden Megu Y. , Yamada Yuya , Takahi Yasumitsu , Obata Yoshinari , Saisho Kenji , Tamba Sachiko , Yamamoto Koji , Umeda Miyuki , Furubayashi Aiko , Tsukamoto Yoshifumi , Sakaguchi Katsuhiko , Matsuzawa Yuji 
Published: February 2012

SummaryObjectiveWith the increasing prevalence of diseases related to obesity, metabolic syndrome and its key player adiponectin are now attracting considerable attention. Hypoadiponectinaemia is reported to be a risk factor for hypertension and associated with endothelial dysfunction, which is closely related to complications of obesity such as hypertension. As there is limited information regarding serum adiponectin levels in normotensive people, we undertook the large‐scale study to determine the association of adiponectin with blood pressure (BP) in mainly normotensive people.Design, patients and measurementsIn 21 100 Japanese adults (12 363 men and 8737 women) who had no apparent diseases, we examined the relationship between the serum adiponectin concentration and BP by performing a questionnaire survey, physical measurements and measurement of laboratory parameters including the serum adiponectin level.ResultsSubjects with hypoadiponectinaemia had higher systolic and diastolic BPs as already reported. And interestingly, subjects with higher adiponectin had lower systolic and diastolic BP. According to linear regression analysis, adiponectin showed a significant negative correlation with systolic and diastolic BP independently of the other variables. Analysis of covariance according to adiponectin quintiles showed that systolic and diastolic BP in highest adiponectin quintile was significantly lower than in other quintiles.ConclusionsThis study revealed that there were significant trends toward lower systolic and diastolic BP with higher adiponectin not only in hypertensive people but also in normotensive people.
Emerging therapeutic strategies for Epstein–Barr virus+ post‐transplant lymphoproliferative disorder
Authors: Hatton Olivia , Martinez Olivia M. , Esquivel Carlos O. 
Published: February 2012

Hatton O, Martinez OM, Esquivel CO. Emerging therapeutic strategies for Epstein–Barr virus+ post‐transplant lymphoproliferative disorder.Abstract:  De novo malignancies represent an increasing concern in the transplant population, particularly as long‐term graft and patient survival improves. EBV‐associated B‐cell lymphoma in the setting of PTLD is the leading malignancy in children following solid organ transplantation. Therapeutic strategies can be categorized as pharmacologic, biologic, and cell‐based but the variable efficacy of these approaches and the complexity of PTLD suggest that new treatment options are warranted. Here, we review current therapeutic strategies for treatment of PTLD. We also describe the life cycle of EBV, addressing the viral mechanisms that contribute to the genesis and persistence of EBV+ B‐cell lymphomas. Specifically, we focus on the oncogenic signaling pathways activated by the EBV LMP1 and LMP2a to understand the underlying mechanisms and mediators of lymphomagenesis with the goal of identifying novel, rational therapeutic targets for the treatment of EBV‐associated malignancies.
System for integrated adherence monitoring: Real‐time non‐adherence risk assessment in pediatric kidney transplantation
Authors: Pai Ahna L. H. , Rausch Joseph , Tackett Alayna , Marsolo Keith , Drotar Dennis , Goebel Jens 
Published: February 2012

Pai ALH, Rausch J, Tackett A, Marsolo K, Drotar D, Goebel J. System for integrated adherence monitoring: Real‐time non‐adherence risk assessment in pediatric kidney transplantation.Abstract:  This study reports initial results of the development of the SIAM, a non‐adherence risk assessment system for tacrolimus and sirolimus for the pediatric kidney transplant population. Forty‐eight youths between 10 and 25 yr of age diagnosed with chronic kidney disease or a kidney transplant used an electronic pill bottle (EM; time stamps each bottle opening) to dispense their medication for at least 30 days or until their next clinic appointment. Youth also completed a self‐report adherence measure, and standard deviations were calculated for the last four medication serum trough levels obtained for each patient. Estimation models were developed for each medication (i.e., SIAMTACRO and SIAMSIRO) to assign weights to these clinically available adherence measures (self‐report and trough levels) for the calculation of a non‐adherence risk composite score. SIAMTACRO models included both self‐report and tacrolimus trough levels and significantly predicted EM. For sirolimus, the model predictive of adherence as measured by EM consisted of the standard deviation of sirolimus trough levels only (SIAMSIRO). Non‐adherence risk can be effectively assessed using clinically available assessment tools. However, the best methods for using self‐report and trough levels to predict non‐adherence likely differ based on the medication for which adherence is being assessed.
Can evolution of sexual dimorphism be triggered by developmental temperatures?
Authors: KETOLA T. , KRISTENSEN T. N. , KELLERMANN V. M. , LOESCHCKE V. 
Published: February 2012

AbstractGenetic prerequisites for the evolution of sexual dimorphism, sex‐specific heritabilities and low or negative genetic correlations between homologous traits in males and females are rarely found. However, sexual dimorphism is evolving rapidly following environmental change, suggesting that sexual dimorphism and its genetic background could be environmentally sensitive. Yet few studies have explored the sensitivity of the genetic background of sexual dimorphism on environmental variation. In this study, onDrosophila melanogaster, we used a large nested full‐sib–half‐sib breeding design where families were split into four different developmental temperatures: two constant temperature treatments of 25 and 30 °C and two cycling temperatures with means of 25 and 30 °C, respectively. After emergence, we tested heat shock tolerance of adult flies. We found that sexual dimorphism was strongly affected by temperature during development. Moreover, we found that female heritability was significantly lower in flies developing at hot temperature and more so under hot and cycling temperatures. Interestingly, most of the genetic variation for heat shock tolerance was orthogonal (i.e. noncorrelated) between sexes, allowing independent evolution of heat shock tolerance in males and females. These findings give support to the hypothesis that the evolution of sexual dimorphism can be influenced by the environments experienced during development.
Do different disparity proxies converge on a common signal? Insights from the cranial morphometrics and evolutionary history of Pterosauria (Diapsida: Archosauria)
Authors: FOTH C. , BRUSATTE S. L. , BUTLER R. J. 
Published: February 2012

AbstractDisparity, or morphological diversity, is often quantified by evolutionary biologists investigating the macroevolutionary history of clades over geological timescales. Disparity is typically quantified using proxies for morphology, such as measurements, discrete anatomical characters, or geometric morphometrics. If different proxies produce differing results, then the accurate quantification of disparity in deep time may be problematic. However, despite this, few studies have attempted to examine disparity of a single clade using multiple morphological proxies. Here, as a case study for this question, we examine the disparity of the volant Mesozoic fossil reptile clade Pterosauria, an intensively studied group that achieved substantial morphological, ecological and taxonomic diversity during their 145+ million‐year evolutionary history. We characterize broadscale patterns of cranial morphological disparity for pterosaurs for the first time using landmark‐based geometric morphometrics and make comparisons to calculations of pterosaur disparity based on alternative metrics. Landmark‐based disparity calculations suggest that monofenestratan pterosaurs were more diverse cranially than basal non‐monofenestratan pterosaurs (at least when the aberrant anurognathids are excluded), and that peak cranial disparity may have occurred in the Early Cretaceous, relatively late in pterosaur evolution. Significantly, our cranial disparity results are broadly congruent with those based on whole skeleton discrete character and limb proportion data sets, indicating that these divergent approaches document a consistent pattern of pterosaur morphological evolution. Therefore, pterosaurs provide an exemplar case demonstrating that different proxies for morphological form can converge on the same disparity signal, which is encouraging because often only one such proxy is available for extinct clades represented by fossils. Furthermore, mapping phylogeny into cranial morphospace demonstrates that pterosaur cranial morphology is significantly correlated with, and potentially constrained by, phylogenetic relationships.
A functional screen for recovery of 4′‐phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries
Authors: Owen J. G. , Robins K. J. , Parachin N. S. , Ackerley D. F. 
Published: February 2012

SummaryThe single‐module non‐ribosomal peptide synthetase BpsA from Streptomyces lavendulae has the unique ability to autonomously synthesize a coloured product (indigoidine) from a single substrate (l‐glutamine), conditional upon activation by a 4′‐phosphopantetheinyl transferase (PPTase) partner. We show that bpsA can be expressed in an entD PPTase gene deleted mutant of Escherichia coli to yield a sensitive reporter strain for recovery of PPTase genes from metagenome libraries. We also show that recombinant bpsA constructs, generated by substitution of the native peptidyl carrier protein domain followed by directed evolution to restore function, can be used to increase the diversity of PPTase genes recovered from a sample. As PPTases are essential for activation of non‐ribosomal peptide synthetase and polyketide synthase enzymes, they are frequently associated with secondary metabolite gene clusters. Nearly half of the PPTases recovered in our screening of two small‐insert soil metagenome libraries were genetically linked to recognizable secondary metabolite biosynthetic genes, demonstrating that PPTase‐targeting functional screens can be used for efficient recovery of natural product gene clusters from metagenome libraries. The plasticity and portability of bpsA reporter genes can potentially be exploited to maximize recovery and expression of PPTase‐bearing clones in a wide range of hosts.