bluuebunny/crossref_metadata_2025_split huggingface dataset:
An assessment of priorities in handling climate change impacts on infrastructures
Authors: Leal Filho Walter , Abeldaño Zuñiga Roberto Ariel , Sierra Javier , Dinis Maria Alzira Pimenta , Corazza Laura , Nagy Gustavo J. , Aina Yusuf A. 
Published: June 2024

AbstractClimate change (CC) will likely significantly impact the world’s infrastructure significantly. Rising temperatures, increased precipitation, and rising sea levels are all likely to stress critical infrastructures (CI). Rising temperatures can lead to infrastructure damage from extreme heat events. This can cause roads and bridges to buckle or crack, leading to costly repairs and potential traffic disruptions. In addition, heat waves can damage vital electrical infrastructure, leading to widespread power outages. In light of this context, this article reports on a study which examined the connections and impacts of CC on infrastructure. The study employed a mixed-method approach, combining bibliometric analysis for the period 1997–2022 with a series of relevant case studies from the five continents to offer insight into the impact of CC on infrastructure. The article fills a research gap in respect of assessments of the extent to which climate change (CC) negative influences the infrastructure, with a special focus on developing countries. It also showcases CI projects and adaptation measures being currently deployed, to address CC. The results show that the current infrastructure is vulnerable to CC. The selected case studies on CI adaptation show that in developing and industrialised countries, there is a perceived need to understand better the connections and potential impacts of CC on critical areas such as transport, settlements, and coastal infrastructure. In order to protect infrastructure from CC impacts, governments need to invest in measures such as flood control, early warning systems, and improved building codes. Additionally, they need to work to reduce greenhouse gas emissions more actively, which are the primary cause of CC.
Investigation of the mechanical behavior of rock-like material with two flaws subjected to biaxial compression
Authors: Lian Shuailong , Wan Wen , Zhao Yanlin , Wu Qiuhong , Du Can 
Published: June 2024

AbstractThe biaxial compression experiments of rock-like materials with two flaws are carried out under different flaw inclination angle, rock bridge ligament angle, lateral stress. The experimental studies show that crack propagation modes of rock-like material are as follows: wing crack through mode (Y mode), shear crack through mode (J mode), mixed crack through mode (wing shear JY mode), longitudinal extension of crack and transverse shear splitting. prefabricated fractured rock specimens have experienced the closing stage of prefabricated fractures, the elastic deformation stage, the generation and expansion of cracks (or plastic strengthening), and the residual loading stage. The peak strength of the specimen is increases with the increase of flaw inclination angle and lateral stress. With the increase of the rock bridge ligament angle, the failure of the rock bridge region changes from the shear crack failure to composite failure of shear crack and the wing type tensile crack failure, and then to the wing crack failure. With the increase of the lateral pressure, the failure of the specimen changes from the wing type tensile crack failure to the wing type and shear crack failure, and then to shear crack failure. The flaw inclination angle mainly changes the form of crack growth but does not effect on the failure modes. The counting number of acoustic emission events at the center of the sample is relative large, indicating that the cacks appear in the part of the rock bridge firstly. With the increasing of loads, the cracks of the rock bridge expanding constantly and connecting finally. The changes of acoustic emission event counts is consistent with the macroscopic damage form obtained from the experiments.
Ethanol consumption in non-human primates alters plasma markers of bone turnover but not tibia architecture
Authors: Zhakubayev Alibek , Sattgast Lara H. , Lewis Anne D. , Grant Kathleen A. , Turner Russell T. , Iwaniec Urszula T. , Benton Mary Lauren 
Published: June 2024

AbstractEthanol consumption is associated with positive, negative, and neutral effects on the skeletal system. Our previous work using a nonhuman primate model of voluntary ethanol consumption showed that chronic ethanol use has an impact on skeletal attributes, most notably on biochemical markers of bone turnover. However, these studies were limited by small sample sizes and resulting lack of statistical power. Here, we applied a machine learning framework to integrate data from 155 monkeys (100 ethanol and 55 controls) to identify the bone features associated with chronic ethanol use. Specifically, we analyzed the influence of ethanol consumption on biomarkers of bone turnover and cancellous and cortical bone architecture in tibia. We hypothesized that chronic ethanol use for 6 months to 2.5 years would result in measurable changes to cancellous features and the biochemical markers compared to control animals. We observed a decrease in bone turnover in monkeys exposed to ethanol; however, we did not find that ethanol consumption resulted in measurable changes in bone architecture.
RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma
Authors: Liu Meng , Bai Ruimin , Zhang Guanfei , Liu Xinyi , Wang Ziyang , He Ke , Gan Xinyi , Zhou Xiaolin , Yin Pan , Zheng Yan , Wang Guorong 
Published: June 2024

AbstractSkin cutaneous melanoma (SKCM) is a highly malignant form of skin cancer, known for its unfavorable prognosis and elevated mortality rate. RARRES1, a gene responsive to retinoic acid receptors, displays varied functions in various cancer types. However, the specific role and underlying mechanisms of RARRES1 in SKCM are still unclear. GSE15605 was utilized to analyze the expression of RARRES1 in SKCM. Subsequently, the TCGA and GEO databases were employed to investigate the relationships between RARRES1 and clinicopathological parameters, as well as the prognostic implications and diagnostic efficacy of RARRES1 in SKCM. GO, KEGG, and GSEA analyses were conducted to explore the potential functions of RARRES1. Furthermore, the associations between RARRES1 and immune infiltration were examined. Genomic alterations and promoter methylation levels of RARRES1 in SKCM were assessed using cBioPortal, UALCAN, and the GEO database. Finally, RARRES1 expression in SKCM was validated through immunohistochemistry, and its functional role in SKCM progression was elucidated via in vivo and in vitro experiments. We found that RARRES1 was downregulated in SKCM compared with normal tissues, and this low expression was associated with worse clinicopathological features and poor prognosis of SKCM. The diagnostic efficacy of RARRES1, as determined by ROC analysis, was 0.732. Through GO, KEGG, and GSEA enrichment analysis, we identified 30 correlated genes and pathways that were mainly enriched in the tumor immune microenvironment, proliferation, apoptosis, and autophagy. Additionally, RARRES1 expression was found to be positively related to the infiltration of various immune cells in SKCM, particularly macrophages and T helper cells, among others. Analysis of genomic alterations and promoter methylation revealed that shallow deletion and hypermethylation of the RARRES1 promoter could lead to reduced RARRES1 expression. IHC validation confirmed the downregulation of RARRES1 in SKCM. Moreover, overexpression of RARRES1 inhibited the proliferation and migration of A375 cells, promoted apoptosis, and inhibited autophagic flux. In the mouse xenograft model, RARRES1 overexpression also suppressed SKCM tumor growth. Collectively, these findings suggest that RARRES1 may function as a suppressor and could potentially serve as a prognostic biomarker and therapeutic target for SKCM.
Oocyte maturation, fertilization, and embryo development in vitro by green and chemical iron oxide nanoparticles: a comparative study
Authors: Nejadali Chaleshtari Shamim , Amini Elaheh , Baniasadi Farzaneh , Tavana Somayeh , Ghalamboran Mohammadreza 
Published: June 2024

AbstractOxidative stress is considered one of the main challenges for in vitro maturation (IVM) and makes assisted reproductive technology (ART), including IVF and embryonic development less effective. Reducing free radicals via biocompatible nanoparticles (NPs) is one of the most promising approaches for developing IVM. We investigated the comparative effect of green and chemically synthesized iron oxide nanoparticles (IONPs) with an aqueous extract of date palm pollen (DPP) on oocyte parameters related to the IVM process. To this end, IONPs were synthesized by chemical (Ch-IONPs) and green methods (G-IONPs using DPP) and characterized. The mature oocyte quality of the Ch-IONPs and G-IONPs groups was evaluated by JC1 and Hoechst staining, Annexin V-FITC-Propidium Iodide, 2′, 7′-dichlorofluorescein diacetate, and dihydroethidium staining compared to the control group. Eventually, the mature oocytes were fertilized, promoted to blastocysts (BL), and evaluated in vitro. Compared with the control and G-IONPs groups, the Ch-IONPs-treated group produced more hydrogen peroxide and oxygen radicals. Compared with the Ch-IONPs group, the fertilization rate in the G-IONPs and control groups increased significantly. Finally, the G-IONPs and control groups exhibited a significant increase in the 2PN, 2-cell, 4-cell, 8-cell, compacted morula (CM), and BL rates compared with the Ch-IONPs group. Green synthesis of IONPs can reduce the toxicity of chemical IONPs during the IVM process. It can be concluded that G-IONPs encased with DPP compounds have the potential to protect against exogenous reactive oxygen species (ROS) production in an IVM medium, which can have a crucial effect on oocyte maturation and fertilization efficiency.
Dissecting the complexity of local and systemic circadian communication in plants
Authors: Mortada Mostafa , Xiong Lu , Mas Paloma 
Published: June 2024

AbstractThe plant circadian clock regulates daily and seasonal rhythms of key biological processes, from growth and development to metabolism and physiology. Recent circadian research is moving beyond whole plants to specific cells, tissues, and organs. In this review, we summarize our understanding of circadian organization in plants, with a focus on communication and synchronization between circadian oscillators, also known as circadian coupling. We describe the different strengths of intercellular coupling and highlight recent advances supporting interorgan communication. Experimental and mathematical evidence suggests that plants precisely balance both the circadian autonomy of individual cellular clocks and synchronization between neighboring cells and across distal tissues and organs. This complex organization has probably evolved to optimize the specific functions of each cell type, tissue, or organ while sustaining global circadian coordination. Circadian coordination may be essential for proper regulation of growth, development, and responses to specific environmental conditions.
Editorial
Authors: Jacobs Collin 
Published: June 2024

Sehr geehrte Kolleginnen und Kollegen,ich freue mich, Ihnen die zweite Ausgabe der IOK dieses Jahres präsentieren zu
dürfen. Als Thema für diese Ausgabe habe ich die klinische Kieferorthopädie gewählt.
Fallbeispiele aus diversen Arbeitsgruppen stellen die Möglichkeiten unseres Faches
dar. Medizinische Indikationen, digitale Diagnostik, individualisierte Planungen und
moderne Therapiekonzepte beschreiben die heutige Kieferorthopädie. Der Einsatz
moderner, Setup-basierter Apparaturen in kieferorthopädischen Fällen, deren
Behandlungsindikationen mehr als nur die Verbesserung der Ästhetik darstellen,
zeigen den Fortschritt unseres Faches. Von „A“ wie Aligner über „L“ wie Lingual bis
„Z“ wie Zentrik ist alles dabei. Die folgenden Beiträge der verschiedenen Autoren
sollen Ihnen Fallbespiele zu verschiedenen Themengebieten darstellen. Die zugehörige
Literatur unterstreicht die Evidenz der verwendeten Therapien im Kontext der
vorhandenen Wissenschaft.
Erwachsenenbehandlung einer Kl.II Malokklusion mit skelettal offenem
Biss und seitlichem Kreuzbiss – Kombination aus chirurgisch unterstützter
Gaumennahterweiterung und vollständig individualisierter
Lingualapparatur
Authors: Schneider Olina , Jacobs Collin 
Published: June 2024

ZusammenfassungDer vorliegende Fallbericht beschreibt die Therapie und das Behandlungsergebnis
eines erwachsenen Patienten mit einer Angle-Klasse II – Malokklusion, einem
skelettal offenen Biss und einem seitlichen Kreuzbiss, welcher durch eine
vollständig individualisierte Lingualapparatur (WIN, DW Lingualsystems, Bad
Essen, Germany) in Verbindung mit einer chirurgisch unterstützten
Gaumennahterweiterung (GNE) behandelt wurde. Eine bilaterale Neutralokklusion
mit physiologischem Overjet und Overbite konnte ohne die primär geplante
Dysgnathie Operation erfolgreich eingestellt werden.
Post–Intensive Care Syndrome in Neurocritical Care Patients
Authors: Dangayach Neha S. , Kreitzer Natalie , Foreman Brandon , Tosto-Mancuso Jenna 
Published: June 2024

AbstractPost–intensive care syndrome (PICS) refers to unintended consequences of critical care that manifest as new or worsening impairments in physical functioning, cognitive ability, or mental health. As intensive care unit (ICU) survival continues to improve, PICS is becoming increasingly recognized as a public health problem. Studies that focus on PICS have typically excluded patients with acute brain injuries and chronic neurodegenerative problems. However, patients who require neurocritical care undoubtedly suffer from impairments that overlap substantially with those encompassed by PICS. A major challenge is to distinguish between impairments related to brain injury and those that occur as a consequence of critical care. The general principles for the prevention and management of PICS and multidomain impairments in patients with moderate and severe neurological injuries are similar including the ICU liberation bundle, multidisciplinary team-based care throughout the continuum of care, and increasing awareness regarding the challenges of critical care survivorship among patients, families, and multidisciplinary team members. An extension of this concept, PICS-Family (PICS-F) refers to the mental health consequences of the intensive care experience for families and loved ones of ICU survivors. A dyadic approach to ICU survivorship with an emphasis on recognizing families and caregivers that may be at risk of developing PICS-F after neurocritical care illness can help improve outcomes for ICU survivors. In this review, we will summarize our current understanding of PICS and PICS-F, emerging literature on PICS in severe acute brain injury, strategies for preventing and treating PICS, and share our recommendations for future directions.
Hemostasis Testing in the Emergency Department: A Narrative Review
Authors: Thonon Henri , Van Nieuwenhove Michael , Thachil Jecko , Lippi Giuseppe , Hardy Michael , Mullier François 
Published: June 2024

AbstractRoutine laboratory screening is typically performed at initial evaluation of the vast majority of presentations to the emergency department (ED). These laboratory results are crucial to the diagnostic process, as they may influence up to 70% of clinical decisions. However, despite the usefulness of biological assessments, many tests performed are inappropriate or of doubtful clinical relevance. This overutilization rate of laboratory testing in hospitals, which represents a significant medical–economic burden, ranges from 20 to 67%, with coagulation tests at the top of the list. While reviews frequently focus on nonintensive care units, there are few published assessments of emergency-specific interventions or guidelines/guidance to date. The aim of this review is to highlight current recommendations for hemostasis evaluation in the emergency setting with a specific analysis of common situations leading to ED admissions, such as suspected venous thrombosis or severe bleeding. We revisit the evidence related to the assessment of patient's hemostatic capacity based on comprehensive history taking and physical examination as well as best practice recommendations for blood sample collection to ensure the reliability of results. This review also includes an examination of various currently available point of care tests and a comprehensive discussion on indications, limitations, and interpretation of these tests.
The effect of cadre–farmer relationship on farmers’ willingness to treat domestic waste: evidence from China
Authors: Jian Bei , Lin Ying , Li Qi , Xu Xiaoqian , Cao Yang , Liu Jiajia , Zhang Han , Qu Mei 
Published: June 2024

AbstractThe construction of an ecologically livable rural environment requires treating rural domestic waste. Farmers, as key participants in rural domestic waste disposal, can improve the rural environment by disposing of domestic waste in an environmentally friendly manner. Few studies have examined the cadre–farmer relationship and its impact on rural waste pollution. Using a questionnaire survey of farmers in Shaanxi Province, China, this study estimates the effect of cadre–farmer relationship on their willingness to treat domestic waste. The findings indicate that a positive cadre–farmer relationship significantly increases farmers’ willingness to treat domestic waste. This positive relationship can also strengthen the positive effects of institutional rules on waste treatment willingness. Further mechanism analysis shows that a good cadre–farmer relationship mobilizes farmers to protect the environment and to comply with national ecological laws and regulations, enhancing their willingness to treat domestic waste. These findings enrich research on rural domestic waste management.
Serum 25-Hydroxyvitamin D Is Associated With Prediabetes, Type 2 Diabetes Mellitus, and Insulin Resistance in Children: A Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies
Authors: Hajhashemy Zahra , Ziaei Rahele , Askari Gholamreza , Saneei Parvane 
Published: June 2024

Abstract

Context
Although several investigations have been conducted on the association between serum vitamin D levels and prediabetes and type 2 diabetes mellitus (T2DM) in children and adolescents, their findings are inconsistent.

Objective
We conducted a systematic review and dose-response meta-analysis to summarize this subject.

Data Sources
The electronic databases of ISI Web of Science, Scopus, PubMed, and motor engineering of Google Scholar were comprehensively searched up to May 2023.

Data Extraction
Epidemiologic studies that investigated the risk of hyperglycemia and insulin resistance in relation to serum 25-hydroxy vitamin D levels in children and adolescents were included.

Data Analysis
Twenty-two investigations, with a total of 38 622 participants, were systematically reviewed. Meta-analysis of 15 studies (n = 32 720 participants) showed that participants with the highest serum vitamin D levels had 42% lower risk of hyperglycemia, compared with those in the lowest category of serum vitamin D levels (relative risk [RR] = 0.58; 95%CI, 0.48, 0.71). Moreover, pooling 8 studies (n = 10 465 participants) illustrated that highest serum vitamin D level was associated with a 44% lower risk of insulin resistance compared with the lowest serum vitamin D level (RR = 0.56; 95%CI, 0.37, 0.83). Based on linear dose-response analysis, each 10 nmol/L increment in serum 25-hydroxy vitamin D was associated with a 6% decreased risk of hyperglycemia and insulin resistance in children. Furthermore, nonlinear dose-response analysis revealed that increasing serum vitamin D concentration from 40 nmol/L to sufficient values (&gt;50 nmol/L) was associated with a decreasing trend in risk of hyperglycemia and insulin resistance.

Conclusion
This meta-analysis revealed inverse associations between serum vitamin D levels and hyperglycemia and insulin resistance in children and adolescents, in a dose-response manner. Increasing serum vitamin D concentration from 40 nmol/L to sufficient values (&gt;50 nmol/L) was associated with a decreasing trend in hyperglycemia and insulin resistance risk. Systematic Review Registration: PROSPERO registration no. CRD42023458155.
Neoplatonism in Schelling’s Of the I and Letters
Authors: Fisher Naomi 
Published: June 2024

Abstract
This chapter details Schelling’s exposure to Neoplatonism in his early education and the way that Neoplatonic commitments are manifested in two of his early writings: Of the I as the Principle of Philosophy and Letters on Dogmatism and Criticism. This chapter argues that Schelling shares with certain Neoplatonists two fundamental commitments. First, Schelling is committed to two kinds of cognition: a lower, discursive kind and a higher, intuitive kind, which he terms intellectual intuition. Second, Schelling is committed to the triad of immanence, procession, and return as the basic grounding structure of the world. This structure is present in his early writings: All things remain immanent in the absolute, which is accessed in intellectual intuition. The absolute is that from which the world of finite things proceeds. Finally, it is that to which all things return, either through moral progress or through creative, artistic activity.
Conclusion
Authors: Fisher Naomi 
Published: June 2024

Abstract
This brief conclusion offers a summary of the major claims of the book and argues for their ongoing historical and philosophical relevance. This conclusion also examines the notion of progress at work in Schelling’s philosophy. Schelling draws on the resources of the past in order to address the idiosyncratic projects and problems of his own philosophical era. Schelling, in his attention to the tradition of Platonism, presents a model for engaging with past philosophy in order to make progress in the present. This conclusion accordingly offers a reflection on the ongoing relevance and resources of Schelling’s philosophy for our own age.
Debt Situation of SNGs in India
Authors: Dwivedi Hari Krishna 
Published: June 2024

Abstract
This chapter discusses the historical trend of debt accumulation in Indian states over the past forty years from 1982. The forty-year period can be broken into three phases, with the first being 1982–2003, during which there was a visible deterioration in the debt position of the states. The period from 2003 to 2015 witnessed the enactment and formalization on the FRBM regime in all the states which contributed to bringing the debt of most states under control. However, the period from 2015 has seen the situation worsening on account of multiple reasons such as the inclusion of the power sector debt under states’ ambit and increased borrowing to fight the Covid-19 pandemic. The trends in gross fiscal deficit and revenue deficit are covered to understand how states have accumulated debt over the years, and to get a better sense of the quality of the debt that states have been undertaking. An interstate comparison of the states’ debt position reveals that there are large differences between the states in terms of their indebtedness as a percentage of their gross state domestic product. Some of the reasons for the poor fiscal condition of the states are also discussed.