bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIFFERENCES BETWEEN PROFILE OF OFFICE, HOME AND 24H AMBULATORY BLOOD PRESSURE MONITORING IN PREECLAMPSIA AND UNCOMPLICATED HYPERTENSION IN PREGNANCY
Authors: Szczepaniak-chichel Ludwina , Lipski Dawid , Uruski Pawel , Tykarski Andrzej 
Published: May 2024

Objective:
Definition of arterial hypertension and management decision making in guidelines is still based on office blood pressure measurement (OBPM), both in general and pregnant population, although in clinical practice 24h ambulatory monitoring (ABPM) seems to be more accurate, which if not available often replaced with home BP (HBPM). Information on differences between values of BP depending on method in course of pregnancy are scarce. Aim of the study was to assess profile and compare results of three methods of BP measurement used simultaneously – HBPM, OBPM and 24 ABPM in pregnancy in real clinical setting with regard to hypertensive status, development of preeclampsia (PE) and time of pregnancy.

Design and method:
In a prospective longitudinal study 241 pregnant women admitted between 2017 and 2023 to outpatient clinic had their BP examined - monthly throughout pregnancy and 6-8 weeks, 6 months and 1 year postpartum. On each occasion data on HBPM (from 7 days prior) were collected, compared with OBPM in standardized conditions (OMRON®-705I) as well as with result of 24h ABPM (AND®TM-2430). Pharmacotherapy in hypertensive patients was managed in accordance with ESH/ESC guidelines.

Results:
We have recruited 40 normotensive controls and 201 women with hypertension (145 chronic; 56 pregnancy induced). Preeclampsia developed in 49 of hypertensives (HT+PE) (18,6% of chronic HT, 39,3% of PIH) – on average in 32,8 w.g. (20-39). SBP/DBP as median are presented in table 1. BP of controls differed significantly from both complicated (HT+PE) and uncomplicated hypertensive patients (HT) in all three methods at all stages of pregnancy and postpartum (p< 0.05). Significant differences between HT+PE and HT are marked in table 2 in gray.

Conclusions:
Regardless of method of BP assessment and good BP control with antihypertensives achieved values in HT pregnancies differed significantly from normotensive pregnancies. Preeclamptic patients were characterized with significantly higher BP values in HBPM, OBPM and – most strongly expressed - in night-ABPM than uncomplicated hypertensives already 2 months before average time of PE recognition. The night-time BP values from ABPM seems to have the strongest predictive and diagnostic value for early recognition of preeclampsia.
Stillbirth Risk and Smallness for Gestational Age According to Hadlock, INTERGROWTH-21st, WHO, and GROW Fetal Weight Standards: Analysis by Maternal Ethnicity and Body Mass Index
Authors: Gardosi Jason , Hugh Oliver 
Published: May 2024

(Abstracted from Am J Obstet Gynecol 2023;229:547.e1–13
Fetal growth during pregnancy is an important marker of fetal health, and fetal growth restriction (FGR) is highly correlated with stillbirth. To mitigate this risk, fetal growth must be assessed accurately and appropriately to recognize risk factors that point to FGR versus a normally developing fetus.
Antibiotic Treatment of Women With Isolated Intrapartum Fever vs Clinical Chorioamnionitis: Maternal and Neonatal Outcomes
Authors: Shqara Raneen Abu , Glikman Daniel , Jad Saher , Rechnitzer Hagai , Lowenstein Lior , Wolf Maya Frank 
Published: May 2024

(Abstracted from Am J Obstet Gynecol. 2023;229:540.e1–540.e9
Clinical chorioamnionitis affects up to 13% of all term pregnancies and up to 70% of spontaneous preterm premature rupture of the membrane. It is a syndrome defined by the presence of intrapartum maternal fever ≥38°C accompanied by at least 2 of the following clinical signs: maternal tachycardia (>100 bpm), fetal tachycardia (>160 bpm), maternal leukocytosis >15,000/mm2, purulent cervical discharge, or uterine tenderness.
The Womb Cancer Awareness Measure (WCAM): Development of an Instrument to Assess Public Awareness of Endometrial Cancer
Authors: Jones Olivia , Young Hannah , Clarke Helen , Crosbie Emma J , Sivalingam Vanitha N 
Published: May 2024

(Abstracted from Int J Gynecol Cancer 2023;34:73–79
This survey study describes the development of the Womb Cancer Awareness Measure (WCAM), an instrument to assess public awareness of endometrial cancer, consisting of items related to knowledge of red flag symptoms and risk factors. The 36-item questionnaire was developed with the input of a panel of scientists, gynecologic oncologists, and patient representatives and aimed to evaluate confidence levels in detecting a red flag symptom and the rapidity of seeking medical care.
Serum Progesterone Is Lower in Ovarian Stimulation With Highly Purified HMG Compared to Recombinant FSH Owing to a Different Regulation of Follicular Steroidogenesis: A Randomized Controlled Trial
Authors: Bosch Ernesto , Alama Pilar , Romero Josep Lluis , Marı Marta , Labarta Elena , Pellicer Antonio 
Published: May 2024

(Abstracted from Hum Reprod 2024;39:393–402
Serum progesterone levels following ovarian stimulation (OS) are associated with the cycle result in terms of ongoing pregnancy and live birth rate, with levels above a certain threshold associated with poorer results. An increase in progesterone is positively associated with the ovarian response and the FSH dose administered during OS; however, this mechanism is not well understood.
Performance Evaluation of a Supervised Machine Learning Pain Classification Model Developed by Neonatal Nurses
Authors: Manworren Renee C. B. , Horner Susan , Joseph Ralph , Dadar Priyansh , Kaduwela Naomi 
Published: May 2024

Background:
Early-life pain is associated with adverse neurodevelopmental consequences; and current pain assessment practices are discontinuous, inconsistent, and highly dependent on nurses’ availability. Furthermore, facial expressions in commonly used pain assessment tools are not associated with brain-based evidence of pain.

Purpose:
To develop and validate a machine learning (ML) model to classify pain.

Methods:
In this retrospective validation study, using a human-centered design for Embedded Machine Learning Solutions approach and the Neonatal Facial Coding System (NFCS), 6 experienced neonatal intensive care unit (NICU) nurses labeled data from randomly assigned iCOPEvid (infant Classification Of Pain Expression video) sequences of 49 neonates undergoing heel lance. NFCS is the only observational pain assessment tool associated with brain-based evidence of pain. A standard 70% training and 30% testing split of the data was used to train and test several ML models. NICU nurses’ interrater reliability was evaluated, and NICU nurses’ area under the receiver operating characteristic curve (AUC) was compared with the ML models’ AUC.

Results:
Nurses weighted mean interrater reliability was 68% (63%-79%) for NFCS tasks, 77.7% (74%-83%) for pain intensity, and 48.6% (15%-59%) for frame and 78.4% (64%-100%) for video pain classification, with AUC of 0.68. The best performing ML model had 97.7% precision, 98% accuracy, 98.5% recall, and AUC of 0.98.

Implications for Practice and Research:
The pain classification ML model AUC far exceeded that of NICU nurses for identifying neonatal pain. These findings will inform the development of a continuous, unbiased, brain-based, nurse-in-the-loop Pain Recognition Automated Monitoring System (PRAMS) for neonates and infants.
Novel therapies in juvenile idiopathic arthritis
Authors: Sage Anne M. , Clarke Sarah L.N. , Ramanan Athimalaipet V. 
Published: May 2024

Purpose of review
This review summarises the major novel treatment options for children with juvenile idiopathic arthritis (JIA) since the pandemic, reflecting not only on advancements in therapeutics but also approach to management and research.

Recent findings
Several recent international paediatric trials have been important in advancing understanding of JIA and furthering available treatment options. Biologic and small molecule agents were demonstrated to be effective and safe in recalcitrant or severe JIA (including extra-articular complications), mirroring the adult equivalent diseases.

Summary
Although joint and overall health have vastly improved for young people with JIA, ongoing international collaboration, critical review of treatment strategies and high quality research are essential to optimize outcomes.
INTEREST OF REGULAR ASSAYS OF AQUEOUS HUMOR INTERLEUKIN-10 LEVELS IN MONITORING OF VITREORETINAL LYMPHOMA
Authors: Metayer Charline , Kodjikian Laurent , Nguyen Anh-Minh , Loria Olivier , Chaperon Mayeul , Ghesquieres Hervé , Mathis Thibaud 
Published: May 2024

Purpose:
To investigate the variation of interleukin-10 (IL-10) levels in the aqueous humor (AH) of patients with vitreoretinal lymphoma (VRL) throughout therapy and follow-up and analyze the relation of these variations with VRL clinical course and relapse.

Methods:
This study retrospectively included consecutive patients diagnosed with VRL in a single center. AH IL-10 samples and patient clinical course were evaluated. The response to treatment was evaluated according to the criteria set by the International Primary Central Nervous System Lymphoma Collaborative Group.

Results:
A total of 59 eyes of 34 patients were included. Interleukin-10 levels decreased significantly at first AH sample after therapy induction (median [IQR] 3.0 [2.8–3.6] months) among patients in complete clinical remission (P < 0.001). Among patients in complete clinical remission with residual detectable IL-10 in AH after therapy induction (85.3% systemic chemotherapy, 11.8% intravitreal methotrexate, 2.9% palliative care), 87.5% experienced ocular relapse within 5 years. The detection of IL-10 in AH at the first visit after induction for complete clinical remission obtained a sensitivity of 77.8% (95% CI 0.45–0.96) and a specificity of 96.4% (95% CI 0.82–0.99) to predict ocular relapse. For relapsing eyes (N = 26), IL-10 significantly increased between the last IL-10 measurement and the time of the first ocular relapse (P < 0.001). In 76.0% of cases, an increase in IL-10 was detected earlier than clinical relapse with a mean (SD) of 4.0 (2.4) months.

Conclusion:
The present study suggested the usefulness of IL-10 in the prognosis of VRL. This study showed a relation between IL-10 in AH and tumoral activity, and for the first time with disease relapse.
MIXED PATHOPHYSIOLOGIES OF LAMELLAR MACULAR HOLES AND RELATED DISEASES
Authors: Matoba Ryo , Kanzaki Yuki , Morita Tetsuro , Masuda Yuki , Kimura Shuhei , Hosokawa Mio M. , Shiode Yusuke , Morizane Yuki 
Published: May 2024

Purpose:
To investigate the characteristics of mixed pathophysiologies in lamellar macular holes (LMHs) and related diseases using multimodal optical coherence tomography.

Methods:
Overall, 126 eyes diagnosed with LMH, epiretinal membrane foveoschisis, or macular pseudohole using the horizontal B-scan image according to the definition proposed by Hubschman et al in 2020 were analyzed using multimodal optical coherence tomography imaging including horizontal and vertical 5-line B-scan, radial scan, and macular three-dimensional volume scan images. If at least two diagnostic criteria for LMH, epiretinal membrane foveoschisis, or macular pseudohole were satisfied in these scans, the patient was diagnosed as having a “mixed type.” Retinal traction force was quantitatively evaluated by measuring the maximum depth of the retinal folds using en-face images.

Results:
Mixed types constituted 34.1% of the cases. The LMH-related mixed group demonstrated intermediate characteristics between the epiretinal membrane foveoschisis/macular pseudohole and true LMH groups in terms of retinal traction and LMH-specific features and had a significant positive correlation between the maximum depth of the retinal folds and mean M-CHARTS scores (P = 0.034).

Conclusion:
A thorough optical coherence tomography analysis is necessary to accurately diagnose LMH and related diseases. A significant positive correlation was observed between the maximum depth of the retinal folds and the degree of metamorphopsia in the LMH-related mixed group.
Ceftazidime Poloxamer Gel: Expanding the Therapeutic Armamentarium for Ciprofloxacin-Resistant Pseudomonas Mastoid Cavity Otorrhea
Authors: Roy Catherine F. , Cohen-Tenoudji Bertrand , Mijovic Tamara 
Published: May 2024

Objective
To present and evaluate the treatment of ciprofloxacin-resistant Pseudomonas mastoid cavity otorrhea with a ceftazidime thermosensitive poloxamer gel.

Study design
A retrospective clinical capsule report.

Patients
Three patients diagnosed with ciprofloxacin-resistant Pseudomonas otorrhea in the setting of a previous canal-wall-down mastoidectomy between March 2019 and June 2023 visiting our tertiary care institution were retrospectively reviewed.

Intervention
Application of a 2% ceftazidime thermosensitive poloxamer gel to mastoid cavity.

Main Outcome Measures
No evidence of disease during microscopic inspection of the ear within a month of initial treatment or bacterial eradication on subsequent culture.

Results
Two patients had complete resolution of symptoms and achieved a safe and dry ear after topical application of the hydrogel. The second patient had pseudomonal eradication on culture, but persistent otorrhea due to other multidrug-resistant bacteria and an anatomically unfavorable mastoid cavity, which ultimately resolved after revision surgery.

Conclusions
This small case series suggests that topical treatment of mastoid cavity otorrhea with a 2% ceftazidime poloxomer gel is a potential therapeutic avenue in patients with ciprofloxacin-resistant Pseudomonas.
Accuracy of the OMRON HEM-7361T blood pressure monitor in the differentiation between atrial fibrillation and sinus rhythm
Authors: Zhou Yi , Xia Jia-Hui , Zhang Wei , Li Yan , Wang Ji-Guang 
Published: May 2024

Objective
We investigated the accuracy of the OMRON HEM-7361T automated oscillometric blood pressure (BP) monitor in the differentiation between atrial fibrillation and sinus rhythm.

Methods
An approximately equal number of patients with persistent atrial fibrillation and individuals with sinus rhythm were recruited from outpatients and inpatients of Ruijin Hospital, Shanghai, China. BP was measured three times consecutively with a 30-s interval with the OMRON HEM-7361T automatic electronic BP monitor for atrial fibrillation detection. A hand-held single lead electrocardiogram device was used for simultaneous electrocardiogram recordings.

Results
The device accurately identified atrial fibrillation in 100 (99.0%) of the 101 patients, with only 1 patient incorrectly classified as non-atrial fibrillation. The device correctly identified 99 (95.2%) of the 104 participants with sinus rhythm as non-atrial fibrillation, with five participants incorrectly classified as atrial fibrillation. The device had a positive predictive value of 95.2%, negative predictive value of 99.0%, and overall accuracy of 97.1%. Among the six misclassified participants, one with atrial fibrillation had a heart rate of 65 beats/min, and four of the five participants with sinus rhythm had cardiac arrhythmias (atrial or ventricular premature beat in one participants, sinus tachycardia in one participant, and both arrhythmias in one participant).

Conclusion
The OMRON HEM-7361T BP monitor is accurate in the differentiation between atrial fibrillation and sinus rhythm. Whether the device is sufficiently accurate in the differentiation between atrial fibrillation and other cardiac arrhythmias remains under investigation.
Validating the accuracy of Omron HEM-7372T1-AZAZ (BP5460) in monitoring blood pressure according to the ISO 81060-2:2018+Amd 1:2020 protocol in the general population
Authors: Takahashi Hakuo , Yamashita Shingo , Yakura Nobuki 
Published: May 2024

Purpose
The performance of the Omron HEM-7372T1-AZAZ (BP5460) in monitoring blood pressure (BP) in the upper arm was validated in accordance with the International Organization for Standardization (ISO) 81060-2:2018 (E) and amendment (Amd)1:2020 protocol.

Methods
The device was used to assess 98 participants who fulfilled the inclusion criteria, including the range of arm circumference and systolic and diastolic BP, in accordance with the protocol. Data validation and analysis were performed according to the manufacturer’s instructions.

Results
In the ISO validation procedure (criterion 1), the mean ± SD of the differences between test device readings and reference BP was 0.3 ± 6.17/3.6 ± 5.26 mmHg (systolic/diastolic). These data fulfilled the ISO requirements of ≤5±≤8 mmHg. The mean differences between the observer measurements and Omron HEM-7372T1-AZAZ (BP5460) readings were 0.3 ± 4.82 mmHg for systolic BP and 3.6 ± 4.78 mmHg for diastolic BP, fulfilling criterion 2 with SD values of ≤6.95 for SBP and ≤5.89 for DBP. Therefore, two ISO criteria were fulfilled.

Conclusion
The Omron HEM-7372T1-AZAZ BP monitor fulfilled the requirements of the ISO validation standard. This device can be recommended for home BP measurements in the general population.
Associations of Homelessness With Primary Care and Acute Care Utilization Among Medicaid-Enrolled Youth
Authors: Yue Dahai , Chuang Emmeline , Zhou Weihao , Essien Elsie A. , Lee Youngeun , O’Masta Brenna , Pourat Nadereh 
Published: May 2024

Background:
Youth comprise one-third of the US homeless population. However, little is known about how homelessness affects health care utilization.

Objective:
Examine associations of homelessness with hospitalization, primary care, and ED visits, varying by race/ethnicity, among Medicaid-enrolled youth.

Research Design:
A cross-sectional analysis was conducted using California Medicaid claims data on youth beneficiaries with complex needs. We examined the number of hospitalizations, preventable and nonpreventable ED, and primary care visits using a multivariate regression. We further explored the differential associations by race/ethnicity.

Results:
Approximately 17% of our sampled youth experienced homelessness in 2018 (N=90,202). Compared with their housed counterparts, youth experiencing homelessness had a 1.9 percentage point (pp) higher likelihood of frequent ED visits (95% CI: 1.7–2.2) but a 2.9 pp lower probability of any primary care visits (95% CI: -3.9 to -1.9). Homelessness was associated with 221 more ED visits (95% CI: 182–260), 100 more preventable ED visits (95% CI: 84–116), 19.9 more hospitalizations (95% CI: 12–27), but 56 fewer primary care visits (95% CI: -104 to -7), per 1000 youth. The associations of homelessness with total ED visits, preventable ED visits, and needed and nonpreventable ED visits were all higher among Whites and, particularly, Blacks than for Hispanics and Asians.

Conclusions:
Medicaid-enrolled youth who experienced homelessness had more overall ED, preventable ED, and hospital visits, but fewer primary care visits than their housed peers. Our results suggest promoting primary care use should be considered among strategies to improve health and reduce costs.
Discussions of Cancer Survivorship Care Needs
Authors: Borders Tyrone F. , Hammerslag Lindsey 
Published: May 2024

Background:
Rural cancer survivors may face greater challenges receiving survivorship care than urban cancer survivors.

Purpose:
To test for rural versus urban inequities and identify other correlates of discussions about cancer survivorship care with healthcare professionals.

Methods:
Data are from the 2017 Medical Expenditure Panel Survey (MEPS), which included a cancer survivorship supplement. Adult survivors were asked if they discussed with a healthcare professional 5 components of survivorship care: need for follow-up services, lifestyle/health recommendations, emotional/social needs, long-term side effects, and a summary of treatments received. The Behavioral Model of Health Services guided the inclusion of predisposing, enabling, and need factors in ordered logit regression models of each survivorship care variable.

Results:
A significantly lower proportion of rural than urban survivors (42% rural, 52% urban) discussed in detail the treatments they received, but this difference did not persist in the multivariable model. Although 69% of rural and 70% of urban ssurvivors discussed in detail their follow-up care needs, less than 50% of both rural and urban survivors discussed in detail other dimensions of survivorship care. Non-Hispanic Black race/ethnicity and time since treatment were associated with lower odds of discussing 3 or more dimensions of survivorship care.

Conclusions:
This study found only a single rural/urban difference in discussions about survivorship care. With the exception of discussions about the need for follow-up care, rates of discussing in detail other dimensions of survivorship care were low among rural and urban survivors alike.
Inequities Along the Human Immunodeficiency Virus (HIV) Pre-exposure Prophylaxis Services Continuum for Black Women in the United States, 2015–2020
Authors: Townes Ashley , Tanner Mary R. , Yu Lei , Johnson Wayne D. , Zhu Weiming , Iqbal Kashif , Dominguez Kenneth L. , Henny Kirk D. , Drezner Kate , Schumacher Christina , Bickham Jacquelyn , Elopre Latesha , Edelstein Zoe R. , Hoover Karen W. ,   On Behalf of the Targeted Highly Effective Interventions to Reverse the HIV Epidemic (THRIVE) Project Team
Published: May 2024

(Abstracted from Obstet Gynecol 2024;143:294–301
Throughout the United States, racial disparities in sexually transmitted infections (STIs) and human immunodeficiency virus (HIV) diagnoses persist. Disproportionately higher rates of diagnosed STIs and HIV infections occur among Black individuals (people who identified as Black or African American were combined into this group).
Effect of Pelvic Floor Muscle Training With Smartphone Reminders on Women in the Postpartum Period: A Randomized Controlled Trial
Authors: Chu Lei , Jin Xia , Wu Siyu , Tong Xiaowen , Li Huaifang , Chen Xinliang 
Published: May 2024

(Abstracted from Urogynecology (Phila) 2024;30:138–146
Long-term pelvic floor dysfunction may be caused by pregnancy and childbirth, with urinary incontinence (UI) prevalence rates of 30% in the first 3 postpartum months and persisting in half of those women 20 years after delivery. Combatting pelvic floor dysfunction is possible through pelvic floor muscle training (PFMT), which may improve overall quality of life, as well as prevent UI, sexual dysfunction, and postpartum pelvic muscle impairment.
Outcomes in Women With Pelvic Organ Prolapse Presenting With Pessary-Related Complications
Authors: Omosigho Ukpebo , Propst Katie , Ferrando Cecile A. 
Published: May 2024

(Abstracted from Urogynecology 2024;30:147–152
Pessaries are an effective first-line treatment for pelvic organ prolapse (POP) and urinary incontinence (UI) symptoms and are associated with significant quality-of-life improvement. In patients willing to consider both pessary and surgery, effectiveness of pessary can rival that of surgical interventions.
Variables Associated With Resolution and Persistence of Ovarian Cysts
Authors: Lasher Anne , Harris Lauren E. , Solomon Angelica L. , Harbin Laura M. , Raby Lauren , Dietrich Charles S. , Kryscio Richard J. , van Nagell John R. , Pavlik Edward J. 
Published: May 2024

(Abstracted from Obstet Gynecol 2023;142:1293–1301
Approximately 15%–20% of women develop ovarian cysts, and roughly 85% resolve within 5 years. However, ovarian cysts do carry a very low potential for malignancy and can be distressing.