bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Truncated Sum of Processing‐Times–Based Learning Model for a Two‐Machine Flowshop Scheduling Problem
Authors: Lai Kunjung , Hsu Peng‐Hsiang , Ting Ping‐Ho , Wu Chin‐Chia 
Published: October 2011

AbstractScheduling with learning effects has gained increasing attention in recent years. A well‐known learning model is called “sum‐of‐processing‐times‐based learning” in which the actual processing time of a job is a nonincreasing function of the jobs already processed. However, the actual processing time of a given job drops to zero precipitously when the normal job processing times are large. Moreover, the concept of learning process is relatively unexplored in a flowshop environment. Motivated by these observations, this article addresses a two‐machine flowshop problem with a truncated learning effect. The objective is to find an optimal schedule to minimize the total completion time. First, a branch‐and‐bound algorithm incorporating with a dominance property and four lower bounds is developed to derive the optimal solution. Then three simulated annealing algorithms are also proposed for near‐optimal solution. The experimental results indicated that the branch‐and‐bound algorithm can solve instances up to 18 jobs, and the proposed simulated annealing algorithm performs well in item of CPU time and error percentage. © 2011 Wiley Periodicals, Inc.
Prediction and assessment of multiple glacial lake outburst floods scenario in Pho Chu River basin, Bhutan
Authors: Osti Rabindra , Egashira Shinji , Adikari Yognath 
Published: October 2011

AbstractIn this study, the characteristic of multiple glacial lake outburst floods (GLOFs) in the Pho Chu River basin in Bhutanese Himalayas is evaluated to help assess the potential impact. Thorthormi Cho (TC) and Lugge Cho (LC) in the east branch and two unnamed lakes labelled A and B in the west branch of Pho Chu are chosen for the study. Numerical models were employed to simulate different involved processes. The results show that the peak sediment discharge in the east branch of the Pho Chu River by the TC dam breach reached about 5000 m3/s (during the first GLOF) at 4 km whereas by the LC dam breach is about 600 m3/s (second GLOF) at 6 km. However, the highest peak hydrographs (sediment and water mixture) calculated during the first and second GLOF are about 10 000 m3/s at the 18‐km section and about 23 000 m3/s at the 10‐km section, respectively. In the west branch of Pho Chu, erosion and depositions are the frequent intermittent local processes during the first GLOF event from Lake A. Because the first event stabilized the irregular river bed profile, there is not much sediment discharge developed during the second GLOF from Lake B. At the 17‐km section of the west branch, the peak hydrograph reached about 9000 m3/s during the first event against the peak of about 800 m3/s during the second event. The results suggest that even if multiple dam breaches occur simultaneously, GLOF surges pass through the main river channel at different times with very different flood characteristics. The differences in travel time and flood characteristics mostly depend on the distributions of bed slope and potential erosion depth along the reach. Further, the amount of sediment accumulated in and transported by each surge is reliant on the temporal geomorphologic setting of the river and therefore on the impact of the previous GLOF on riverbed profile and potential erosion depth. The robustness in peak GLOF hydrographs is associated with sediment flow dynamics. As a consequence, serious inundation of Punakha, Lobeysa and major portion of Wangdue Phodrang is anticipated. Copyright © 2011 John Wiley & Sons, Ltd.
Mixing law versus discharge and electrical conductivity relationships: application to an alpine proglacial stream
Authors: Dzikowski Marc , Jobard Sylvain 
Published: October 2011

AbstractMixing laws have been used in hydrogeology for decades. In glacial hydrology, they are used to determine the contributions of the different reservoirs supplying the proglacial stream. However, some assumptions about discharge–solute matter and discharge–electrical conductivity (EC) relationships have led to erroneous conclusions. Analysis of a theoretical example indicated a hyperbolic relationship between discharge and solute matter concentration/EC for two reservoirs. We applied this approach to experimental data from the Baounet Glacier (Savoie, France), assuming that the proglacial stream is provided by a combination of watershed groundwater flow (diurnally stable and with high EC) and quick drainage from the glacier (low EC and discharge that change very quickly). Applying mixing laws allowed us to characterise these two flows and to separate the quick flows (glacial ablation and rainfalls). Copyright © 2011 John Wiley & Sons, Ltd.
Homologous recombination induced by doxazosin mesylate and saw palmetto in the Drosophila wing‐spot test
Authors: Gabriel Katiane Cella , Dihl Rafael Rodrigues , Lehmann Mauricio , Reguly Maria Luiza , Richter Marc François , de Andrade Heloisa Helena Rodrigues 
Published: October 2011

ABSTRACTBenign prostatic hyperplasia (BPH) is the most common tumor in men over 40 years of age. Acute urinary retention (AUR) is regarded as the most serious hazard of untreated BPH. α‐Blockers, such as doxazosin mesylate, and 5‐α reductase inhibitors, such as finasteride, are frequently used because they decrease both AUR and the need for BPH‐related surgery. An extract of the fruit from American saw palmetto plant has also been used as an alternative ttreatment for BPH. The paucity of information available concerning the genotoxic action of these compounds led us to assess their activity as inducers of different types of DNA lesions using the somatic mutation and recombination test in Drosophila melanogaster. Finasteride did not induce gene mutation, chromosomal mutation or mitotic recombination, which means it was nongenotoxic in our experimental conditions. On the other hand, doxazosin mesylate and saw palmetto induced significant increases in spot frequencies in trans‐heterozygous flies. In order to establish the actual role played by mitotic recombination and by mutation in the genotoxicity observed, the balancer‐heterozygous flies were also analyzed, showing no increment in the total spot frequencies in relation to the negative control, for both drugs. Doxazosin mesylate and saw palmetto were classified as specific inducers of homologous recombination in Drosophila proliferative cells, an event linked to the loss of heterozygosity. Copyright © 2011 John Wiley & Sons, Ltd.
Expression and activity of alcohol and aldehyde dehydrogenases in melanoma cells and in melanocytes
Authors: Amann Philipp M. , Hofmann Claudia , Freudenberger Muriel , Holland‐Cunz Stefan , Eichmüller Stefan B. , Bazhin Alexandr V. 
Published: October 2011

AbstractDisturbances in vitamin A metabolism are an important attribute of some cancer cells. Most evidence point that these disturbances lead to decreasing of the retinoic acid concentration in tumor cells. Up to now, in benign and malignant skin cells the features of vitamin A metabolism with its participating enzymes are not entirely understood. Alcohol and aldehyde dehydrogenases (ALDH) are involved in the retinol metabolism, oxidizing retinol, and retinal in retinoic acid or reducing retinal in retinol. In this work we investigated the expression and enzymatic activity of alcohol and ALDH in melanoma cells compared to their benign counterparts. We demonstrated that melanoma cell lines and melanocytes despite similar pattern of the enzyme expression, show different general ALDH activity. Retinal, the substrate of ALDH, could stimulate the ALDH activity through up‐regulation of retinaldehyde dehydrogenase 1 and aldehyde dehydrogenase 6. Furthermore, we found that retinoids regulate alcohol dehydrogenase activity, probably via effects on alcohol dehydrogenase expression at the post‐transcriptional level. We suggest that melanoma cells in contrast to melanocytes should favor the retinal reduction over its oxidation. The decreasing cellular amount of the precursor molecules of retinoic acid could result in a changed gene regulation in melanoma cells. J. Cell. Biochem. 113: 792–799, 2012. © 2011 Wiley Periodicals, Inc.
Regulatory effects of curcumin on lipid accumulation in monocytes/macrophages
Authors: Zingg Jean‐Marc , Hasan Syeda T. , Cowan Danica , Ricciarelli Roberta , Azzi Angelo , Meydani Mohsen 
Published: October 2011

AbstractRecent evidence suggests potential benefits from phytochemicals and micronutrients in protecting against atherosclerosis and inflammation, but the molecular mechanisms of these actions are still unclear. Here, we investigated whether the dietary polyphenol curcumin can modulate the accumulation of lipids in monocytes/macrophages. Curcumin increased the expression of two lipid transport genes, the fatty acids transporter CD36/FAT and the fatty acids binding protein 4 (FABP4/aP2; P < 0.05), leading to increased lipid levels in THP‐1 and RAW264.7 monocytes and macrophages (P < 0.05). To investigate the molecular mechanisms involved, we assessed the activity of Forkhead box O3a (FOXO3a), a transcription factor centrally involved in regulating several stress resistance and lipid transport genes. Curcumin increased FOXO3a‐mediated gene expression by twofold (P < 0.05), possibly as a result of influencing FOXO3a phosphorylation and nuclear translocation. The curcumin derivative, tetrahydrocurcumin (THC), with similar chemical antioxidant activity as curcumin, did not show any measurable effects. In contrast to the in vitro results, curcumin showed a trend for reduction of lipid levels in peritoneal macrophages in LDL receptor knockout mice fed a high fat diet for 4 months, suggesting additional regulatory mechanisms in vivo. Thus, the up‐regulation of FOXO3a activity by curcumin could be a mechanism to protect against oxidant‐ and lipid‐induced damage in the inflammatory cells of the vascular system. J. Cell. Biochem. 113: 833–840, 2012. © 2011 Wiley Periodicals, Inc.
AMP‐activated protein kinase mediates erythropoietin‐induced activation of endothelial nitric oxide synthase
Authors: Su Kuo‐Hui , Yu Yuan‐Bin , Hou Hsin‐Han , Zhao Jin‐Feng , Kou Yu Ru , Cheng Li‐Ching , Shyue Song‐Kun , Lee Tzong‐Shyuan 
Published: October 2011

AbstractWe investigated whether AMP‐activated protein kinase (AMPK), a multi‐functional regulator of energy homeostasis, participates in the regulation of erythropoietin (EPO)‐mediated activation of endothelial nitric oxide synthase (eNOS) in endothelial cells (ECs) and mice. In ECs, treatment with EPO increased the phosphorylation of AMPK, acetyl‐CoA carboxylase (ACC), and eNOS, as revealed by Western blot analysis. Inhibition of AMPK activation by compound C or dominant‐negative AMPK mutant abrogated the EPO‐induced increase in the phosphorylation of AMPK, ACC, and eNOS, as well as nitric oxide (NO) production. Additionally, suppression of AMPK activation abolished EPO‐induced EC proliferation, migration and tube formation. Immunoprecipitation analysis demonstrated that AMPK mediated the EPO‐induced increase in the phosphorylation of β common receptor (βCR) and the formation of a βCR–AMPK–eNOS complex. In mice, inhibition of AMPK activation by compound C markedly decreased EPO‐elicited angiogenesis in Matrigel plugs. Furthermore, the phosphorylation of AMPK and eNOS was significantly higher in aortas from EPO transgenic mice than wild‐type mice. Moreover, treatment with EPO neutralizing antibody greatly reduced the exercise training‐induced increase in phosphorylation of AMPK and eNOS in aortas of wild‐type mice. Taken together, EPO may trigger AMPK‐dependent signaling, which leads to enhanced phosphorylation of βCR and eNOS, increased βCR–AMPK–eNOS complex formation, NO production, and, ultimately, angiogenesis. J. Cell. Physiol. 227: 3053–3062, 2012. © 2011 Wiley Periodicals, Inc.
Ganoderma lucidum polysaccharides prevent platelet‐derived growth factor‐stimulated smooth muscle cell proliferation in vitro and neointimal hyperplasia in the endothelial‐denuded artery in vivo
Authors: Wang Shu‐Huei , Liang Chan‐Jung , Weng Yu‐Wen , Chen Yung‐Hsiang , Hsu Hsien‐Yeh , Chien Hsiung‐Fei , Tsai Jaw‐Shiun , Tseng Ying‐Chin , Li Chi‐Yuan , Chen Yuh‐Lien 
Published: October 2011

AbstractGanoderma lucidum is used in traditional Chinese medicine to prevent or treat a variety of diseases, including cardiovascular disorders. We previously demonstrated that a glucan‐containing extract of Reishi polysaccharides (EORP) has the potent anti‐inflammatory action of reducing ICAM‐1 expression in lipopolysaccharide (LPS)‐treated human aortic smooth muscle cells (HASMCs) and LPS‐treated mice. In the present study, we examined whether EORP inhibited platelet‐derived growth factor‐BB (PDGF)‐stimulated HASMC proliferation and the mechanism involved. EORP dose‐dependently reduced cell numbers and DNA synthesis of PDGF‐treated HASMCs in vitro. EORP also arrested cell cycle progression in the G0/G1 phase, and this was associated with decreased expression of cyclin D1, cyclin E, CDK2, CDK4, and p21Cip1 and upregulation of the cyclin‐dependent kinase inhibitor p27Kip1. The anti‐proliferative effect of EORP was partly mediated by downregulation of PDGF‐induced JNK phosphorylation. In in vivo studies, the femoral artery of C57BL/6 mice was endothelial‐denuded and the mice were fed a diet containing 100 mg/kg/day of EORP. On day 14, both cell proliferation (proliferating cell nuclear antigen‐positive cells) in the neointima and the neointima/media area ratio (0.67 ± 0.03 vs. 1.46 ± 0.30) were significantly reduced. Our data show that EORP interferes with the mitogenic activation of JNK, preventing entry of HASMCs into the cell cycle in vitro and reducing cell proliferation in the neointima and decreasing the neointimal area in vivo. Thus, EORP may represent a safe and effective novel approach to the prevention and treatment of vascular proliferative diseases. J. Cell. Physiol. 227: 3063–3071, 2012. © 2011 Wiley Periodicals, Inc.
Monocytes differentiation upon treatment with a peptide corresponding to the C‐terminus of activated T cell‐expressed Tirc7 protein
Authors: Mouline Caroline C. , Beranger Guillaume E. , Schmid‐Antomarchi Heidy , Quincey Danielle , Momier David , Boukhechba Florian , Carle Georges F. , Rochet Nathalie , Scimeca Jean‐Claude 
Published: October 2011

AbstractAtp6v0a3 gene encodes for two alternative products, Tirc7 and a3 proteins, which are differentially expressed in activated T cells and resorbing osteoclasts, respectively. Tirc7 plays a central role in T cell activation, while a3 protein is critical for osteoclast‐mediated bone matrix resorption. Based on the large body of evidences documenting the relationships between T cells and osteoclasts, we hypothesized that the extracellular C‐terminus of Tirc7 protein could directly interact with osteoclast precursor cells. To address this issue, we performed the molecular cloning of a mouse Atp6v0a3 cDNA segment encoding the last 40 amino acids of Tirc7 protein, and we used this peptide as a ligand added to mouse osteoclast precursor cells. We evidenced that Tirc7‐Cter peptide induced the differentiation of RAW264.7 cells into osteoclast‐like cells, stimulated an autocrine/paracrine regulatory loop potentially involved in osteoclastic differentiation control, and strongly up‐regulated F4/80 protein expression within multinucleated osteoclast‐like cells. Using a mouse bone marrow‐derived CD11b+ cell line, or total bone marrow primary cells, we observed that similarly to Rankl, Tirc7‐Cter peptide induced the formation of TRACP‐positive large multinucleated cells. At last, using mouse primary monocytes purified from total bone marrow, we determined that Tirc7‐Cter peptide induced the appearance of small multinucleated cells (3–4 nuclei), devoid of resorbing activity, and which displayed modulations of dendritic cell marker genes expression. In conclusion, we report for the first time on biological effects mediated by a peptide corresponding to the C‐terminus of Tirc7 protein, which interfere with monocytic differentiation pathways. J. Cell. Physiol. 227: 3088–3098, 2012. © 2011 Wiley Periodicals, Inc.
Proteasome modulator 9 is linked to microvascular pathology of T2D
Authors: Gragnoli Claudia 
Published: October 2011

AbstractThe locus 12q24 is linked to type 2 diabetes (T2D) and to changes in retinal vascular caliber in Caucasians. Proteasome Modulator 9 gene (PSMD9) lies in the 12q24 locus and is implicated in diabetes onset and in degradation of intracellular proteins in antigenic peptides in the immune response to antigen presentation by MHC class I cells. Within PSMD9, we reported a linkage to T2D and to MODY3 in Italian families. We recently demonstrated a linkage of the PSMD9 T2D risk SNPs with T2D‐nephropathy, T2D‐neuropathy, retinopathy, hypercholesterolemia, and macrovascular pathology. We aimed at studying the presence of the linkage signal of the PSMD9 T2D risk SNPs IVS3 + nt460, IVS3 + nt437, E197G to microvascular pathology associated to T2D in Italian siblings/families. We screened 200 T2D siblings/families for the PSMD9 above‐mentioned variants and performed a parametric and non‐parametric linkage study by Merlin software. Our results show significant LOD score in linkage with microvascular pathology for the PSMD9 SNPs studied using the non‐parametric and parametric linkage analysis. The strongest signal is present under the recessive model. Our statistical power relies on the presence of T2D affected siblings, which represent an ideal dataset to identify linkage with a recessive disease model. Our simulation analysis confirms that the results are not due to random chance. In summary, the PSMD9 IVS3 + nt460, IVS3 + nt437, E197G SNPs are linked via the recessive model to microvascular pathology of T2D in Italians. A possible role of PSMD9 in microvascular pathology may be related to a causative pathogenetic role in inflammation as part of an autoimmune process. J. Cell. Physiol. 227: 3116–3118, 2012. © 2011 Wiley Periodicals, Inc.
The effect of short‐term hypoxic exposure on metabolic gene expression
Authors: Everett Meredith V. , Antal Corina E. , Crawford Douglas L. 
Published: October 2011

AbstractThe long‐term effect of hypoxia is to decrease both the production and use of ATP and thus decrease the reliance on mitochondrial oxidative energy production. Yet, recent studies include more immediate affects of hypoxia on gene expression and these data suggest the maintenance of mitochondrial function. To better understand the short‐term physiological response to hypoxia, we quantified metabolic mRNA expression in the heart ventricles and livers of the teleost fishFundulus grandisexposed to partial oxygen pressure of 2.8 kPa (∼13.5% air saturation).Twenty‐eight individuals from a single population were exposed to hypoxia for 0, 4, 8, 12, 24, 48, and 96 hr. Liver and cardiac tissues were sampled from the same individuals at 0–48 hr. At 96 hr, only cardiac tissue was assayed. Gene expression was significantly different (ANOVA,P<0.05) for 17 of 226 metabolic genes (7.5%) in cardiac tissue and for 20 of 256 (7.8%) metabolic genes in hepatic tissue. For the two tissues examined in this study, the maximum response occurred at different times. For cardiac tissue, using Dunnett's post hoc test, most of these significant differences occurred at 96 hr of exposure. For liver, all but one significant difference occurred at 4 hr. Surprisingly, too many (relative to random expectations) of the genes with significant increase in mRNA are involved in the oxidative phosphorylation pathway: 44% of the significant genes at 96 hr in the heart and 33% of the significant genes at 4 hr in the liver are involved in the oxidative phosphorylation pathway. These data indicate that there are tissue‐specific differences in the timing of the response to hypoxia, yet both cardiac and hepatic tissues have increases in mRNA that code for enzyme in the oxidative phosphorylation pathway. If these changes in mRNA produce a similar change in protein, then these data suggest that the initial response to hypoxia involves an increase in the oxidative pathway potentially as a mechanism to maintain ATP production.J. Exp. Zool. 317:9–23, 2012. © 2011 Wiley Periodicals, Inc.
A tropical oviparous lizard, Calotes versicolor, exhibiting a potentially novel FMFM pattern of temperature‐dependent sex determination
Authors: Inamdar (Doddamani) Laxmi S. , V. Vani , Seshagiri Polani B. 
Published: October 2011

AbstractAmong squamate reptiles, lizards exhibit an impressive array of sex‐determining modes viz. genotypic sex determination, temperature‐dependent sex determination, co‐occurrence of both these and those that reproduce parthenogenetically. The oviparous lizard, Calotes versicolor, lacks heteromorphic sex chromosomes and there are no reports on homomorphic chromosomes. Earlier studies on this species presented little evidence to the sex‐determining mechanism. Here we provide evidences for the potential role played by incubation temperature that has a significant effect (P<0.01) on gonadal sex and sex ratio. The eggs were incubated at 14 different incubation temperatures. Interestingly, 100% males were produced at low (25.5±0.5°C) as well as high (34±0.5°C) incubation temperatures and 100% females were produced at low (23.5±0.5°C) and high (31.5±0.5°C) temperatures, clearly indicating the occurrence of TSD in this species. Sex ratios of individual clutches did not vary at any of the critical male‐producing or female‐producing temperatures within as well as across the seasons. However, clutch sex ratios were female‐ or male‐biased at intermediate temperatures. Thermosensitive period occurred during the embryonic stages 30–33. Three pivotal temperatures operate producing 1:1 sex ratio. Histology of gonad and accessory reproductive structures provide additional evidence for TSD. The sex‐determining pattern, observed for the first time in this species, that neither compares to Pattern I [Ia (MF) and Ib (FM)] nor to Pattern II (FMF), is being referred to as FMFM pattern of TSD. This novel FMFM pattern of sex ratio exhibited by C. versicolor may have an adaptive significance in maintaining sex ratio. J. Exp. Zool. 317:32–46, 2012. © 2011 Wiley Periodicals, Inc.
Corporate social responsibility as a bolster for economic performance: Evidence from emerging markets
Authors: Lagoarde‐Segot Thomas 
Published: October 2011

AbstractAlthough the main responsibility of firms may be to maximize their profits, organizations stand to gain much from the development of corporate social responsibility (CSR) strategies. This article reviews the connection between CSR and financial performance and discusses existing multilateral initiatives that global managers and investors are taking to align their business decisions with social and environmental needs. Moreover, an analysis of developments in six emerging markets—Malaysia, South Africa, Egypt, Turkey, Brazil, and Morocco—highlights how ongoing regulatory reforms provide incentives for company sustainability. The adoption of proactive CSR strategies while generating and disseminating robust and quantitative extra‐financial information to shareholders and regulators is an emerging driver of global competitiveness. Therefore, regulators and leaders of industrial organizations and business schools would do well to incorporate these elements into their twenty‐first‐century strategies. © 2011 Wiley Periodicals, Inc.