bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis pengaruh motivasi belajar, self-efficacy, dan pengalaman mengajar terhadap kompetensi pedagogik mahasiswa pendidikan administrasi perkantoran
Authors: Choerunissa Ira , Tusyanah Tusyanah 
Published: February 2025

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh variabel motivasi belajar, self-efficacy, dan pengalaman mengajar terhadap kemampuan kompetensi pedagogik pada mahasiswa. Jenis penelitian ini adalah menggunakan kuantitatif. Populasi penelitian ini sejumlah 108 mahasiswa dan sampel sejumlah 76 mahasiswa Pendidikan Administrasi Perkantoran angkatan 2020. Teknik pengambilan sampel yang digunakan adalah teknik nonprobability sampling yang merujuk kepada teknik purposive sampling. Pengambilan data penelitian menggunakan angket. Metode analisis data menggunakan analisis regresi linier berganda. Hasil dari penelitian ini diantaranya (1) Terdapat pengaruh secara parsial positif dan signifikan motivasi belajar terhadap kemampuan kompetensi pedagogik. (2) Terdapat pengaruh positif dan signifikan self-efficacy terhadap kemampuan kompetensi pedagogik. (3) Terdapat pengaruh positif dan signifikan pengalaman mengajar terhadap kemampuan kompetensi pedagogik. (4) Terdapat pengaruh positif dan signifikan secara simultan variabel motivasi belajar, self-efficacy dan pengalaman mengajar terhadap kemampuan kompetensi pedagogik pada mahasiswa Pendidikan Ekonomi Administrasi Perkantoran Universitas Negeri Semarang tahun 2020.Kata Kunci: Kemampuan Kompetensi Pedagogik; Motivasi Belajar; Self-Efficacy; Pengalaman Mengajar Analysis of the influence of learning motivation, self-efficacy, and teaching experience on the pedagogical competence of office administration education students. Abstract: The purpose of this study was to analyze the influence of learning motivation variables, self-efficacy, and teaching experience on the ability of pedagogical competence in students. This type of research is quantitative. The population of this study was 108 students and the sample was 76 students of Office Administration Education class of 2020. The sampling technique used is a nonprobability sampling technique that refers to a purposive sampling technique. Research data collection using a questionnaire. The data analysis method uses multiple linear regression analysis. The results of this study include (1) There is a partially positive and significant effect of learning motivation on pedagogical competence. (2) There is a positive and significant influence of self-efficacy on the ability of pedagogical competence. (3) Teaching experience has a positive and significant effect on pedagogical competence. (4) There is a simultaneous positive and significant effect of learning motivation, self-efficacy, and teaching experience variables on pedagogical competence abilities in Office Administration Economics Education students at Semarang State University in 2020.
Health-demand ventilation control strategy in northern Chinese homes: how much ventilation do we need to protect occupants’ health
Authors: Wang Zhigang , Hou Jing , Fu Jinming , Tian Zhe , Feng Shuyuan , Kosonen Risto , Sun Yuexia 
Published: February 2025

IntroductionIndoor air quality in dwellings has particular importance regarding occupants’ health. Ventilation is an important means to improve indoor air quality and guarantee occupants’ health.MethodsWe utilized CO2 produced by occupants to measure air exchange rate (i.e., the volumetric out-to-indoor airflow rate divided by building volume, h−1) in Chinese homes, which were then linked to health outcomes like asthma and sick building syndrome symptom. Finally, we proposed a “health-demand” ventilation control strategy according to the relationship between air exchange rate and health outcomes.Results and DiscussionEach 0.1 h−1 increase in air exchange rate at night was associated with adjusted odds ratios of 0.97 (Confidence Interval (CI): 0.94–1.00) for rhinitis among children and 0.95 (95% CI: 0.91–0.98) for mucosal sick building symptom among adults. Finally, we proposed a “health-demand” ventilation control strategy according to the relationship between air exchange rate and health outcomes. Air exchange rate of 2.5 h−1 and 6.5 h−1 was suggested to deal with sick building syndrome symptoms among adults and rhinitis symptoms among children, respectively.
Trajectory of gut microbiota before and after pediatric cardiopulmonary bypass surgery
Authors: Yin Xi , Xiao Minhua , Sun Jing , Feng Jinqing , Xia Shuliang , Li Fengxiang , Liu Xihong , Li Jia 
Published: February 2025

BackgroundVaried congenital heart disease (CHD) may induce gut microbiota dysbiosis due to intestinal hypoperfusion or/and hypoxemia. Microbiota dysbiosis has been found in preoperative infants and cardiopulmonary bypass (CPB) exacerbated it further. However, the trajectory of gut microbiota from pre- to early post-CPB and one-year later remains unexplored. We examined this trajectory in the two most common CHDs, i.e., left-to-right shunt (ventricular septal defect, VSD) vs. right-to-left shunt (tetralogy of Fallot, TOF).MethodsWe enrolled 13 infants with VSD and 11 with TOF, and collected fecal samples at pre- and early post-CPB. 10 and 12 age- and gender-matched healthy control infants were enrolled respectively. We also enrolled 13 and 9 gender- and CHD diagnosis- and operation-matched one-year post-CPB patients, and 8 age- and gender-matched healthy control children. 16S rRNA sequencing of fecal samples were performed.ResultsCompared to the control groups, both VSD and TOF pre-CPB groups had significantly increased Enterobacteriaceae and Shigella, and decreased Bifidobacterium (Ps ≤ 0.049). No significant change in microbial community diversity was observed between pre- and early post-CPB periods (Ps≥0.227). Compared with early post-CPB, one-year post-CPB groups had significantly increased short-chain fatty acids-producing microbes (Ps ≤ 0.025), and their microbial communities were close to that of the control group (Ps≥0.102). There was no significant difference in microbial communities between VSD and TOF groups in any of 3 periods (Ps≥0.055).ConclusionIn children with VSD or TOF, gut microbiota dysbiosis existed preoperatively and were not significantly altered by CPB. One-year post-CPB, microbiota significantly improved towards normal. Similar microbial communities were found between children with VSD and TOF throughout the perioperative and long-term postoperative periods.
The association between cardiovascular diseases and their subcategories with the severity of chronic obstructive pulmonary disease: a large cross-sectional study based on a Chinese hospital population cohort
Authors: Li Tianye , Chen Lefu , Xu Hao , Zheng Yanhong , Yang Heying , Zhao Hongjun , Chen Chengshui 
Published: February 2025

BackgroundCurrent evidence suggests that cardiovascular disease (CVD) plays a role in the progression of chronic obstructive pulmonary disease (COPD). However, the relationship between CVD and the severity of COPD remains inadequately understood. Therefore, this study aims to elucidate the association between CVD and the severity of COPD.MethodsIn this cross-sectional study involving 7,152 individuals with COPD., Logistic regression, subgroup and sensitivity analyses were employed to evaluate the association between CVD, its subcategories, and the severity of COPD.ResultsMultivariable logistic regression analysis showed that CVD and hypertension remained independently associated with COPD severity (P &lt; 0.001). Patients with CVD had a 1.701 times higher risk of developing severe or very severe COPD compared to those without CVD, while patients with hypertension had a 1.686 times higher risk of developing severe or very severe COPD compared to those without hypertension (P &lt; 0.05). Subgroup analyses showed that the association between CVD and COPD severity remained stable among men, patients ≤ 70 years of age, patients &gt; 70 years of age, BMI &lt; 24 or ≥24 kg/m2, and never smokers, whereas coronary artery disease was significantly associated with COPD severity only among patients ≤ 70 years of age and never smokers (P &lt; 0.05). In addition, hypertension was also stably associated with COPD severity among men, patients ≤ 70 years of age, patients &gt; 70 years of age, BMI &lt; 24 or ≥24 kg/m2, and never smokers. Sensitivity analyses reconfirmed the robustness of the associations of CVD and hypertension with COPD severity among patients who excluded bronchiectasis, tuberculosis, lung cancer, pulmonary hypertension, pulmonary heart disease, and diabetes (P &lt; 0.05).ConclusionThe strong association between CVD and its subcategories (mainly hypertension) and the severity of COPD suggests that the potential risk of exacerbation of CVD should also be addressed in the clinical management of patients with COPD. However, limitations of the cross-sectional design may limit the extrapolation of the results, and more large prospective clinical cohort studies are needed in the future to further validate the association.
Impact of targeted interventions on success of high-risk engineering students: a focus on historically underrepresented students in STEM
Authors: Atindama Emmanuel , Ramsdell Michael , Wick David P. , Mondal Sumona , Athavale Prashant 
Published: February 2025

IntroductionThe study examines the impact of targeted educational interventions on the academic success and retention of engineering students identified as high-risk, with a focus on two student groups historically underrepresented in STEM: underrepresented minority (URM) and female students. These interventions included an alternative curriculum pathway, a co-calculus support course, and spatial visualization training. Building on our previous work, we evaluated the outcomes of interventions designed to improve retention and graduation rates among the most academically underprepared students from these groups, who were consequently categorized as high-risk.MethodologyWe analyzed data from 10 student cohorts, covering 5 years before and 5 years after the interventions were implemented. We utilized a two-population proportion test to compare the groups' retention rates, graduation rates, and success in early STEM courses during pre- and post-intervention periods. Additionally, we constructed logistic regression models to identify key factors influencing on-time graduation.ResultsOur results show that the interventions significantly increased both the 4- and 6-year graduation rates for high-risk URM students by nearly 20 percentage points. Although high-risk female students improved retention and graduation rates, these changes were not found to be statistically significant. However, their performance in early foundation STEM courses, particularly Physics I and Calculus I, significantly improved post-intervention.DiscussionLogistic regression models indicated a shift in the significance of the graduation rate predictors post-intervention, demonstrating the efficacy of these tailored strategies. The reduced importance of Physics I grades in predicting on-time graduation during the intervention years suggests a benefit of the alternative curriculum pathway, which decoupled this course from Calculus I for high-risk students. Additionally, the intervention mitigated the previously significant predictor of being non-URM for on-time graduation, indicating a leveling effect for URM students. These findings highlight the potential of customized interventions to enhance the academic outcomes and retention of high-risk students in STEM disciplines.
Comprehensive analysis of the multifaceted role of ITGAV in digestive system cancer progression and immune infiltration
Authors: Shi Xinyue , Zang Jingyu , Gu Qi , Zhang Mengmeng , Sun Handi , Yang Lijun , Cheng Jiahui , Wang Ruonan , Mao Han , Xu Aitong , Wang Xin , Xiao Yu , Cai Jialing , Han Fang , Yang Depeng , Li Yu , Nie Huan 
Published: February 2025

BackgroundDigestive system cancers are among the most common malignancies, exhibiting consistently high incidence and mortality rates, yet effective detection and treatment targets remain limited. Integrin αv (ITGAV, CD51) is a significant member of the integrin family, widely recognized for its role in mediating interactions between cells and the extracellular matrix, as well as intracellular signaling. In recent years, ITGAV has been found to have significantly elevated expression in multiple tumors, such as prostate cancer, breast cancer, and osteosarcoma, and was considered to be a key component in various stages of tumor progression. However, no systematic digestive system cancer analysis has been conducted to explore its function in prognosis, diagnosis, and immunology.MethodsTranscriptome sequencing and clinical data of samples were obtained from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression Project (GTEx), Human Protein Atlas (HPA), cBioPortal, TIMER and TISIDB databases. Bioinformatics methods were employed to investigate the potential oncogenicity of ITGAV, focusing specifically on the analysis of its prognosis, diagnostic value, and immune infiltration level of ITGAV in digestive system cancers. In addition, GO, KEGG, and PPI network analysis revealed the biological functions and related signaling pathways related to ITGAV. Finally, the role of ITGAV in regulating cancer progression was experimentally verified using hepatocellular carcinoma and pancreatic cancer as examples.ResultsWe found that ITGAV was highly expressed in multiple digestive system cancers. In addition, high expression of ITGAV was closely associated with poor prognosis and showed potential for early diagnosis. Enrichment of pathways related to extracellular matrix organizing processes and tumor migratory movements was identified. In vitro, results showed that the knockdown of ITGAV significantly inhibited the migratory movement ability of hepatocellular carcinoma and pancreatic cancer cells, while its overexpression significantly promoted the migration of the above cells. Finally, immunoassays showed a significant correlation between ITGAV expression and the infiltration level of various immune cells, further clarifying the critical role of ITGAV in the tumor immune microenvironment.ConclusionOur results elucidated the importance of ITGAV in the prognostic assessment, early diagnosis, and targeted immunotherapy of digestive system cancers, and revealed its multifaceted role in regulating cancer progression.
Integrative analysis of m7G methylation-associated genes prognostic signature with immunotherapy and identification of LARP1 as a key oncogene in head and neck squamous cell carcinoma
Authors: Xu Juan , You Zihao , Zhu Zhongping , Liu Min , Zhang Zheng , Xu Panpan , Dong Juanjuan , Huang Yuting , Wang Chao , Qin Haotian 
Published: February 2025

BackgroundN7-methylguanosine (m7G) methylation is an RNA modification associated with cancer progression, but its specific role in head and neck squamous cell carcinoma (HNSCC) remains unclear.MethodsThis study analyzed the differential expression of m7G-related genes (m7GRGs) in HNSCC using the TCGA-HNSCC dataset, identifying key pathways associated with the cell cycle, DNA replication, and focal adhesion. A LASSO-Cox regression model was constructed based on four m7GRGs (EIF3D, EIF1, LARP1, and METTL1) and validated with GEO datasets and clinical samples. Further validation of gene upregulation in HNSCC tissues was conducted using RT-qPCR and immunohistochemistry, while the role of LARP1 in HNSCC cells was assessed via knockout experiments.ResultsThe constructed model demonstrated strong predictive performance, with the risk score significantly correlating with prognosis, immune infiltration, and drug sensitivity. An external dataset and clinical specimens further confirmed the model’s predictive accuracy for immunotherapy response. Additionally, two regulatory axes—LINC00707/hsa-miR-30b-5p/LARP1 and SNHG16/hsa-miR-30b-5p/LARP1—were identified. LARP1 knockout experiments revealed that suppressing LARP1 markedly inhibited HNSCC cell proliferation, migration, and invasion.ConclusionThe m7GRG-based prognostic model developed in this study holds strong clinical potential for predicting prognosis and therapeutic responses in HNSCC. The identification of LARP1 and its related regulatory pathways offers new avenues for targeted therapy in HNSCC.
Novel mRNA vaccines induce potent immunogenicity and afford protection against tuberculosis
Authors: De Voss Christopher J. , Korompis Marcellus , Li Shuailin , Ateere Alberta , McShane Helen , Stylianou Elena 
Published: February 2025

IntroductionMycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a disease with a severe global burden. The intractability of Mtb has prevented the identification of clear correlates of protection against TB and hindered the development of novel TB vaccines that are urgently required. Lipid nanoparticle (LNP)-formulated mRNA is a highly promising vaccine platform that has yet to be thoroughly applied to TB.MethodsWe selected five Mtb antigens (PPE15, ESAT6, EspC, EsxI, MetE) and evaluated their potential as LNP-formulated mRNA vaccines, both when each antigen was delivered individually, and when all five antigens were combined in a mix regimen (m-Mix).ResultsEach mRNA construct demonstrated unique cellular and humoral immunogenicity, and both m-Mix, as well as the single antigen EsxI, conferred significant protection in a murine Mtb challenge model. Whilst the potent immune responses of each mRNA were maintained when applied as a boost to BCG, there was no additional increase to the efficacy of BCG. Combination of m-Mix with a recombinant, replication-deficient chimpanzee adenovirus (ChAdOx1), in a heterologous prime-boost delivery (C-m-Mix), appeared to result in increased protection upon murine Mtb infection, than either regimen alone.DiscussionThis work warrants further investigation of LNP-formulated mRNA vaccines for TB, whilst indicating the potential of m-Mix and C-m-Mix to progress to further stages of vaccine development.
Effect of dietary glycemic index on insulin resistance in adults without diabetes mellitus: a systematic review and meta-analysis
Authors: Yu Yu-Ting , Fu Yu-Hsiang , Chen Yi-Hsien , Fang Yu-Wei , Tsai Ming-Hsien 
Published: February 2025

Low glycemic index (LoGI) diets are associated with decreased insulin resistance and are an effective strategy for patients with diabetes mellitus to control postprandial glucose levels. However, whether these effects on insulin resistance and glucose levels are also observable in those without diabetes mellitus is poorly understood. The present study examined the influence of LoGI diets compared with that of high glycemic index (HiGI) diets on insulin resistance in adults without diabetes mellitus. This meta-analysis included six randomized controlled trials involving 192 participants with a mean age of 52.5 years. A homeostasis model assessment of insulin resistance (HOMA-IR) score was calculated for each trial, and differences in HOMA-IR before and after each dietary intervention were calculated independently. The primary outcome was variations in insulin resistance, which was assessed by proxy as the difference between HOMA-IR scores at the beginning and end of the trials. The results suggested that LoGI diets decrease HOMA-IR scores to a greater extent than HiGI diets (estimate: 0.31; 95% confidence interval [CI], 0.01–0.61; p &lt; 0.001) in individuals without diabetes mellitus. This association remained significant (estimate: 0.16; 95% CI, 0.01–0.31) after excluding one study with a short follow-up time (7 days). In conclusion, LoGI diets lower HOMA-IR scores to a greater extent than HiGI diets in adults without diabetes mellitus.Systematic review registration(https://www.crd.york.ac.uk/PROSPERO/).
Mining and analysis of dizziness adverse event signals in postoperative analgesia patients based on the FDA adverse event reporting system database
Authors: Zhou Fengqi , He Haiou , Zhang Zhen , Gao Jing 
Published: February 2025

ObjectiveThis study aimed to explore the association between drugs used in postoperative anesthesia patients and postoperative dizziness using the U.S. Food and Drug Administration’s Adverse Event Reporting System (FAERS) database, along with other risk factors for dizziness.MethodsUsing the FAERS database, we retrospectively analyzed dizziness cases reported between 2004 and the third quarter of 2023. We analyzed the relationship between drugs during postoperative anesthesia and the risk of postoperative dizziness, and conducted subgroup analysis according to age, sex and other factors. Signal detection was further performed using the reported odds ratio (ROR) method to identify medications significantly associated with an increased risk of postoperative dizziness.ResultsA total of 166,292 dizziness case reports were obtained, with 128 cases specifically related to postoperative analgesia. The number of dizziness reports has been increasing yearly, with a higher concentration of cases among individuals aged 18–85 years, predominantly in female patients. The analysis identified that amitriptyline, clonazepam, and ketamine were significantly associated with an increased risk of dizziness, with RORs of 34.91, 17.39, and 7.37, respectively. Subgroup analyses revealed variations in the relative risk of dizziness based on sex and age groups. Ketamine may be associated with higher risk of dizziness in the adult male subgroup.ConclusionThe results of this study suggest that specific medications used by patients with postoperative analgesia are associated with an increased risk of postoperative dizziness. Future studies should further validate this finding and explore other potential risk factors.
Novel human single-domain antibodies exert potent anti-tumor activity by targeting EGF-like repeat epitope of EpCAM
Authors: Zhou Xiaofeng , Liu Zhifang , Zhang Weixiong , Dai Lin , Chen Tao , Lin Zexiong , Pan Hong , Qi Qi , Wei Henry 
Published: February 2025

IntroductionEpCAM (Epithelial cell adhesion molecule) is a key cancer stem cell marker involved in cancer progression, making it an important target for both diagnosis and therapy. Despite efforts using anti-EpCAM monoclonal antibodies (mAbs), their anti-tumor effects have been limited. Single-domain antibodies (sdAbs), in contrast, offer advantages such as efficient tumor penetration and reduced immunogenicity. This study aims to screen and explore novel sdAbs targeting EpCAM for cancer therapy.MethodsA critical EGF-like repeat epitope on the EpCAM extracellular domain was selected for screening a human sdAb library via phage display. The selected sdAbs were purified and their anti-cancer activity was validated through specific binding with the EpCAM peptide. The effects of these sdAbs on cell proliferation, migration, invasion, and apoptosis were tested in vitro, and their anti-tumor activity was assessed in a xenograft model.ResultsFive fully human anti-EpCAM sdAbs were isolated, all of which specifically bound to the EpCAM peptide and showed selective binding to various cancer cell lines, but not to 293T and 3T3 cells. Functional assays demonstrated that these sdAbs significantly inhibited cancer cell proliferation, migration, and invasion, and induced apoptosis. Notably, two sdAbs (aEP3D4 and aEP4G2) exhibited potent anti-tumor effects in vivo, significantly reducing tumor volume and weight in a mouse xenograft model.DiscussionThis study provides compelling evidence that targeting EpCAM with sdAbs is a promising approach for cancer treatment. The identified anti-EpCAM sdAbs exhibit substantial anti-tumor activity both in vitro and in vivo, suggesting they are strong candidates for future therapeutic applications in cancer therapy.