bluuebunny/crossref_metadata_2025_split huggingface dataset:
A reflection on continuing professional development
Authors: O'Loughlin Kieran , Guerandel Allys , Malone Kevin 
Published: May 2012

SummaryThe enactment of Part II of the Medical Practitioners Act 2007 in Ireland heralds a move from voluntary to statutory provision of professional competence and marks an important advance in medical professionalism in the country. This formalises consultant psychiatrists' existing commitment to updating their knowledge and skills and compels basic and higher specialist trainees to actively engage in the process. The relevance of reflective practice for professional and personal development of trainee psychiatrists is discussed and the role of existing trainee learning activities in the process of lifelong learning is explored in this context.
Long-Term Analysis of the IFM 99 Trials for Myeloma: Cytogenetic Abnormalities [t(4;14), del(17p), 1q gains] Play a Major Role in Defining Long-Term Survival
Authors: Avet-Loiseau Hervé , Attal Michel , Campion Loic , Caillot Denis , Hulin Cyrille , Marit Gerald , Stoppa Anne-Marie , Voillat Laurent , Wetterwald Marc , Pegourie Brigitte , Voog Eric , Tiab Mourad , Banos Anne , Jaubert Jerome , Bouscary Didier , Macro Margaret , Kolb Brigitte , Traulle Catherine , Mathiot Claire , Magrangeas Florence , Minvielle Stephane , Facon Thierry , Moreau Philippe 
Published: May 2012

Purpose In multiple myeloma, many prognostic parameters have been proposed. However, all of these predict shorter survival. To identify patients with a longer life expectancy, we updated the data of patients treated in the IFM (Intergroupe Francophone du Myelome) 99-02 and 99-04 trials. Patients and Methods A series of 520 patients was analyzed. Median follow-up was 90.5 months. To perform a comprehensive analysis of the major prognostic factors, we reanalyzed all patients for 1q gains [in addition to updating del(13), t(4;14), and del(17p) analyses]. Results It was possible to identify a subgroup of patients (representing 20% of total patients) with an 8-year survival of 75%. These patients were defined by the absence of t(4;14), del(17p), and 1q gain and β2-microglobulin less than 5.5 mg/L. Conclusion We propose that all patients with newly diagnosed multiple myeloma be evaluated for these three chromosomal changes, not only to define high-risk patients but also to identify those with a longer life expectancy.
Panobinostat in Patients With Relapsed/Refractory Hodgkin's Lymphoma After Autologous Stem-Cell Transplantation: Results of a Phase II Study
Authors: Younes Anas , Sureda Anna , Ben-Yehuda Dina , Zinzani Pier Luigi , Ong Tee-Chuan , Prince H. Miles , Harrison Simon J. , Kirschbaum Mark , Johnston Patrick , Gallagher Jennifer , Le Corre Christophe , Shen Angela , Engert Andreas 
Published: May 2012

Purpose Hodgkin's lymphoma (HL) has no standard of care for patients who are relapsed or refractory to autologous stem-cell transplantation (ASCT). This phase II study examined safety and activity of panobinostat in this population. Patients and Methods Panobinostat 40 mg was administered orally three times per week. The primary end point was objective response rate (ORR) based on investigator assessment of radiologic imaging. Secondary end points included ORR by independent central review, time to response (TTR), duration of response (DOR), progression-free survival (PFS), overall survival, and safety. Exploratory biomarker analyses were performed. Results The 129 treated patients (median age, 32 years; range, 18 to 75 years) were heavily pretreated with a median of four (range, two to seven) prior systemic regimens, and 41% did not respond to the regimen immediately preceding panobinostat. Tumor reductions occurred in 96 patients (74%). Objective response was achieved by 35 patients (27%), including 30 (23%) partial responses and five (4%) complete responses. The median TTR was 2.3 months, median DOR was 6.9 months, and median PFS was 6.1 months. The estimated 1-year overall survival rate was 78%. Common nonhematologic adverse events (AEs)—diarrhea, nausea, vomiting, and fatigue—were generally grade 1 and 2. Most common grade 3 and 4 hematologic AEs—thrombocytopenia, anemia, and neutropenia—were manageable. Early reductions in thymus and activation-regulated chemokine were observed in patients achieving complete or partial response. Conclusion In the largest, prospective, multicenter, international trial conducted in heavily pretreated patients with HL who relapsed or were refractory to ASCT, panobinostat monotherapy demonstrated antitumor activity, resulting in durable responses.
The effect of settling velocity on the transport of mussel larvae in a cobble‐bed river: Water column and near‐bed turbulence
Authors: Schwalb Astrid Nadine , Morris Todd James , Ackerman Josef Daniel 
Published: May 2012

Lay AbstractSimple transport models predict that the distance small organisms such as larvae “drift” downstream in rivers is determined by their settling velocity, the release height, and the stream velocity. However, natural turbulent conditions in a river may also affect the downstream transport and dispersion (spread) of larvae. The main goal of this study was to examine how stream velocity and larval settling velocity (Mucket [Actinonaias ligamentina] and the Wavy‐rayed Lampmussel [Lampsilis fasciola] differ by 2.5 times) affect the transport of freshwater unionid mussel larvae in the Grand River, Ontario, Canada. Larvae were released and captured in a series of nets downstream. Larval spread in rivers appeared to be strongly affected by stream flow conditions. Larvae were spread more rapidly with increased stream velocity likely due to increased turbulence in the water. Overall there was a good agreement between measured downstream decrease in capture of larvae and predictions from a 3‐dimensional advection–diffusion model that considered the spread due to hydrodynamics. However, in contrast to the predictions of simple transport models, differences in settling velocity had no detectable effect on the transport of larvae. Future studies are necessary to further explore the role of settling velocity and other factors under different stream flow conditions, which may also be important for dispersal of other organisms and particles.
Diagnostic accuracy of dual-time-point 18F-FDG PET/CT for the detection of axillary lymph node metastases in breast cancer patients
Authors: Hahn Steffen , Hecktor Jennifer , Grabellus Florian , Hartung Verena , Pöppel Thorsten , Kimmig Rainer , Forsting Michael , Antoch Gerald , Heusner Till A 
Published: May 2012

Background The diagnostic accuracy of FDG-PET/CT for the detection of axillary lymph node metastases in breast cancer patients acquired 60 min after FDG administration is reported to be only moderate, especially due to low sensitivity. Purpose To test whether a delayed scan 90 min after FDG administration could enhance the diagnostic accuracy of FDG-PET/CT for the detection of axillary lymph node metastases. Material and Methods Thirty-eight women suffering from primary breast cancer (mean age 52 years; range 25–78 years; standard deviation 14 years) underwent a pre-therapeutic dual-time-point FDG-PET/CT scan. The maximum standardized uptake value (SUVmax) of axillary lymph nodes was measured at two different time points (time point T1: 60 min after FDG injection, time point T2: 90 min after FDG injection). SUVmax of axillary lymph nodes at T1 and T2 were assessed for statistical significance using a paired Wilcoxon-Test ( P < 0.05). At T1 a qualitative analysis of the FDG-PET/CT scan was performed to define physiologic and metastatic lymph nodes. At T2 an increase of the SUVmax of at least 3.75% over time was rated as indicating malignancy. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the accuracy of FDG-PET/CT for the detection of axillary lymph node metastases was calculated at time points T1 and T2. Statistically significant differences were determined using Fisher's exact test ( P < 0.05). Histopathology served as the standard of reference. A compartment based analysis was done. Results Axillary lymph nodes had a mean SUVmax of 1.6 (range 0.6–10.8; SD 1.9) at T1 and a mean SUVmax of 1.8 (range 0.5–17.9; SD 3.5) at T2. This difference was statistically significant ( P = 0.047). The sensitivity, specificity, PPV, NPV, and accuracy of FDG-PET/CT for the detection of axillary lymph node metastases was 81%, 100%, 100%, 88%, and 92% at T1, and 88%, 50%, 56%, 85%, and 66% at T2, respectively. This difference was not statistically significant ( P = 0.27). Conclusion There is a slight increase of the FDG accumulation of axillary lymph nodes between 60 and 90 min after FDG administration. This increase did not translate into a statistical significant enhancement of the diagnostic accuracy of FDG-PET/CT for the detection of axillary lymph nodes. Especially due to false-positive results a delayed FDG-PET/CT scan 90 min after FDG administration is not able to enhance the diagnostic accuracy for the detection of lymph node metastases.
Transarterial chemoembolization for hepatocellular carcinoma after transjugular intrahepatic portosystemic shunt
Authors: Kang Ji-Won , Kim Jin Hyoung , Ko Gi-Young , Gwon Dong Il , Yoon Hyun-Ki , Sung Kyu-Bo 
Published: May 2012

Background The decreased portal blood flow and the potential decrease in arterial nutrient hepatic blood flow after creation of a transjugular intrahepatic portosystemic shunt (TIPS) makes the treatment of hepatocellular carcinoma (HCC) challenging. Purpose To evaluate the safety and efficacy of transarterial chemoembolization (TACE) after TIPS in patients with HCC. Material and Methods From 1998 to 2009, 20 patients underwent selective (segmental or subsegmental) TACE for HCC after TIPS. Among 20 patients, seven patients had undergone one to three sessions of TACE for HCC before TIPS creation. TACE was performed using a mixture of iodized oil and cisplatin, and absorbable gelatin sponge particles. Tumor response, complications, and patient survival were evaluated after TACE. Results After TACE, 14 of the 20 (70%) patients showed a tumor response, with only one (5%) experiencing a TACE-related major complication, spontaneous bacterial peritonitis. None of the patients who underwent TACE after TIPS died within 30 days. During the follow-up period (range 2.2–107 months; mean 32.6 months), 18 patients died and two remained alive. The median survival period after TACE was 23 months. Multivariate Cox regression analysis showed that tumor stage was the only independent prognostic factor for patient survival ( P = 0.049). Conclusion Selective TACE may be safe and effective for the palliative treatment of HCC in patients with TIPS. Late tumor stage ( ≥III) was poor prognostic factor for determining the patient survival period after post-TIPS TACE.
Spatial Textile Reinforcement Structures for Ventilated and Sandwich Facade Elements
Authors: Hegger Josef , Kulas Christian , Horstmann Michael 
Published: April 2012

Textile Reinforced Concrete (TRC) is a new composite material using mesh-like technical textiles to transfer tensile forces in a concrete member. The main advantage in using these reinforcements is the reduction of concrete covers to only few millimeters leading to slender and light-weight concrete applications like ventilated facade elements and sandwich panels with TRC facings. Based on three applications, which are realized in the last two years, it is revealed that there is a need not only for capable planar fabrics but also for spatial structures. Inherently stable reinforcement structures are achieved by impregnating the fabrics with a resin (e.g. epoxy resin) and curing the structures in the desired shape at temperatures up to 180°C. Moreover, the utilization of the cross-section of the rovings is homogenized and, thus, a tensile strength up to 1400 MPa is achieved for AR-glass fabrics. The article deals with selected applications for facade structures made of TRC, material properties and demands on the textile reinforcement as well as production processes. Furthermore, test results regarding the load-bearing behavior of these selected applications are presented.
Numerical simulation of 2D granular particles and its analyses by means of the micropolar fluid model
Authors: Takechi Kohei , Yoshida Kyo , Arimitsu Toshihico 
Published: April 2012

AbstractNumerical simulations of two-dimensional granular flows under uniform mean shear and external body torque were performed following the setting of the authors’ previous study [10]. Convergence of the stresses with the increase of coarse-graining length is investigated. Difference R between vorticity field and spin field is controlled by the external torque and the stresses for the region R > 0 is obtained as well as those for R < 0. The symmetry of the stresses under the change of the sign of R is discussed.
Irradiation in the treatment of arthrofibrosis after total knee arthroplasty: a preliminary trial
Authors: Baier Clemens , Springorum Hans-Robert , Maderbacher Günther , Winkler Sebastian , Füchtmeier Bernd , Neugebauer Rainer 
Published: April 2012

Abstract
Postoperative arthrofibrosis after primary and revision total knee arthroplasty is a severe complication for the affected patient. Several risk factors have been identified for this diagnosis. We present a series of 3 patients with arthrofibrosis after (revision) total knee arthroplasty. Approximately 2 hours before the operative revision procedure, all patients were irradiated once with 7.01 gray. At latest follow-up, all 3 patients showed a distinct improvement of range of motion. Before revision total knee arthroplasty due to arthrofibrosis, a single dose of pre- or postoperative irradiation should be considered.
Angiokeratoma of Fordyce in man and woman — case reports
Authors: Bjekić Milan , Marković Milica , Šipetić Sandra 
Published: April 2012

Abstract
Angiokeratomas are papular vascular lesions characterized by marked ectasia of the superficial dermal blood vessels. Dermatological examination of angiokeratomas of Fordyce is characterized by papular keratotic lesions of erythematous-violet color. They are more common in the scrotum, and vulval involvement is rarely reported. This article reports the cases of angiokeratoma of Fordyce in a 25-year-old man and a 42-year-old woman. Diagnosis were made by history and physical examination. Dermoscopy has shown well-demarcated round dark lacunae in both patients. As the lesions were asymptomatic, the patients requested no further treatment.
Modulation of physiological and pathological activities of lysozyme by biological membranes
Authors: Trusova Valeriya 
Published: April 2012

AbstractThe molecular details of interactions between lipid membranes and lysozyme (Lz), a small polycationic protein with a wide range of biological activities, have long been the focus of numerous studies. The biological consequences of this process are considered to embrace at least two aspects: i) correlation between antimicrobial and membranotropic properties of this protein, and ii) lipid-mediated Lz amyloidogenesis. The mechanisms underlying the lipid-assisted protein fibrillogenesis and membrane disruption exerted by Lz in bacterial cells are believed to be similar. The present investigation was undertaken to gain further insight into Lz-lipid interactions and explore the routes by which Lz exerts its antimicrobial and amyloidogenic actions. Binding and Förster resonance energy transfer studies revealed that upon increasing the content of anionic lipids in lipid vesicles, Lz forms aggregates in a membrane environment. Total internal reflection fluorescence microscopy and pyrene excimerization reaction were employed to study the effect of Lz on the structural and dynamic properties of lipid bilayers. It was found that Lz induces lipid demixing and reduction of bilayer free volume, the magnitude of this effect being much more pronounced for oligomeric protein.
Estimation of Chloride Migration Coefficient in Air-Entrained Concretes Containing Fluidized Bed Combustion Fly Ash / Ocena Współczynnika Migracji Jonów Chlorkowych W Betonach Zawierajacych Popiół Fluidalny
Authors: Józwiak-Niedźwiedzka D. 
Published: April 2012

Abstract The objective of this investigation was comparing the penetration of chloride ions in ordinary and air-entrained concretes containing a waste material Fluidized Bed Combustion Fly Ash (FBCFA). All concretes were tested with 15% and 30% cement replacement by FBCFA, with the same water-binder ratio of 0.45. Two kinds of fly ash coming from fluid bed combustion in two power plants in Poland have been used.In this study the rapid chloride permeability test - Nordtest Method BUILD 492 method - was used. The microstructure of the concrete was analyzed on thin polished sections and the measurement of air voids sizes and their distribution, using digital image analysis, was carried on according to PN-EN 480-11:2008.Obtained results have shown a significant influence of partial cement replacement by FBCFA on the chloride ions movements in concrete. It has been found that this kind of addition reduced considerably the chloride ion penetration. The influence of air entrainment on the chloride diffusion coefficients was also measured and it was shown that application of air-entraining admixture for concretes with FBCFA reduce the chloride diffusion coefficient but it should be used with caution.
Selection of Parameters of Dowelling Connections in Concrete Airport Pavement / Wpływ Dyblowania Na Przemieszczenia I Naprezenia W Betonowych Nawierzchniach Lotniskowych
Authors: Dacko M. , Brodzik R. 
Published: April 2012

Abstract The article presents numerical analysis of the portion of concrete airport pavement that consists of two concrete panels connected with dowels, subjected to thermal and service loads, in terms of changes in base rigidity, plate thickness and diameters, and spacing of dowels. Modifications of the thickness of the plates, diameter and spacing of dowels, and base rigidity were considered by assessing the level of stress and displacement in the analysed concrete plate, as well as normal and tangential stresses in dowels by using finite element method. On the basis of an analysis of examples, an optimal solution of dowelling connections in concrete plates with established loads was proposed. The results of the calculations were presented as a contour level distributions and comparison tables.
Estimation of internal radiation exposure using a whole body counter
Authors: Pliszczyński Tomasz , Ośko Jakub , Ciszewska Katarzyna , Haratym Zbigniew , Umaniec Marianna , Sosnowiec Renata 
Published: April 2012

Ocena narażenia wewnętrznego za pomocą licznika promieniowania ciała człowieka
Proces oceny narażenia wewnętrznego na skażenia substancjami promieniotwórczymi jest skomplikowany i towarzyszy mu wiele czynników, które są źródłem niepewności szacowania obciążającej dawki efektywnej. W niniejszym artykule przedstawiono sposób właściwego postępowania podczas szacowania obciążającej dawki efektywnej za pomocą Licznika Promieniowania Ciała Człowieka.
Analysis of the measurement uncertainty during calibration of radioherapy and radiodiagnostics dosemeters at the Polish Secondary Standard Dosimetry Laboratory
Authors: Ulkowski Piotr , Bulski Wojciech , Gwiazdowska Barbara 
Published: April 2012

Analiza niepewności pomiaru współczynnika wzorcowania dawkomierzy terapeutycznych i diagnostycznych, wzorcowanych w polskim Laboratorium Wtórnych Wzorców Dozymetrycznych
Celem pracy było opracowanie metody szacowania niepewności i wstępne określenie wartości szacowanych wielkości w przypadku wzorcowanych w LWWD dawkomierzy. Zastosowano metodę obliczania niepewności typu A i B wg międzynarodowej normy ISO. Uwzględniono stosowany w LWWD sposób wzorcowania dawkomierzy wg raportów Międzynarodowej Agencji Energii Atomowej. Przedstawione wyniki dotyczą wszystkich wzorcowanych w LWWD dawkomierzy. Zarówno szczegółowa analiza wszystkich etapów wzorcowania jak i otrzymane wyniki wskazują, że niepewność pomiarów jest w zakresie akceptowanym przez Polskie Centrum Akredytacji.
A Method of determination of ambient quality factor of fast neutrons in mixed radiation fields using advanced recombination methods
Authors: Zielczyński Mieczysław , Golnik Natalia , Gryziński Michał 
Published: April 2012

Sposób wyznaczania przestrzennego współczynnika jakości neutronów prędkich w polach promienowania mieszanego wykorzystujacy zaawansowane metody rekombinacyjne
Przedstawiono sposób wyznaczania przestrzennego współczynnika jakości neutronów prędkich, Qn
*(10), w polu promieniowania mieszanego o nieznanym, lecz ograniczonym, widmie energii neutronów. W tym sposobie wykorzystuje się korelacje między wartościami Qn
*(10), obliczonymi metodą Monte Carlo dla neutronów monoenergetycznych, a parametrami doświadczalnych charakterystyk nasycenia komory rekombinacyjnej, umieszczonej we wzorcowych polach neutronów monoenergetycznych wraz z towarzyszącym promieniowaniem gamma. Omija się przy tym szereg niepewności, m.in. związanych z brakiem pełnej odpowiedniości między współczynnikiem jakości promieniowania a parametrami, od których zależy lokalna rekombinacja jonów, a także z brakiem pełnej odpowiedniości konstrukcji komory rekombinacyjnej z tzw. kulą MKJR (ang. ICRU) definiującą wielkości operacyjne H*(10) i Q*(10).
First Order Languages: Further Syntax and Semantics
Authors: Caminati Marco 
Published: April 2012

First Order Languages: Further Syntax and SemanticsThird of a series of articles laying down the bases for classical first order model theory. Interpretation of a language in a universe set. Evaluation of a term in a universe. Truth evaluation of an atomic formula. Reassigning the value of a symbol in a given interpretation. Syntax and semantics of a non atomic formula are then defined concurrently (this point is explained in [16], 4.2.1). As a consequence, the evaluation of any w.f.f. string and the relation of logical implication are introduced. Depth of a formula. Definition of satisfaction and entailment (aka entailment or logical implication) relations, see [18] III.3.2 and III.4.1 respectively.
Some Features of Regular Spaces in Supra Fuzzy Topology
Authors: Hoque M. F. , Hossain M. S. , Ali D. M. 
Published: May 2012

We introduce and study supra fuzzy a-regular spaces and we establish some relationships among them in this paper. We also study some other properties of these concepts and obtain their several features.Keywords: Fuzzy regular spaces; Supra fuzzy regular spaces.© 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v4i2.8157 J. Sci. Res. 4 (2), 373-382 (2012)
Synthesis and Characterization of Vanadium Substituted Potassium Tungsten Bronzes, K<sub>x</sub>V<sub>y</sub>W<sub>1-y</sub>O<sub>3</sub>
Authors: Abdullah A. M. , Debnath T. , Rüscher C. H. , Hussain A. 
Published: May 2012

A series of vanadium substituted potassium hexagonal tungsten bronzes KxVyW1-yO3 (K-HTB) were prepared by conventional solid state method at 800 °C with compositions of x = 0.30 and 0.00 ? y ? 0.15. A mixture of K-HTB and non bronze phases with y ? 0.20 was observed. The proportion of this non bronze phase increases with increasing vanadium content. The non bronze phases in the mixture could not be indexed yet. In contrast, a very small amount of vanadium can be substituted in potassium tetragonal tungsten bronzes (K-TTB) at 800 °C with x = 0.50 and 0.00 ? y ? 0.02, however at 700 °C vanadium substituted K-TTB can be prepared with 0.00 ? y ? 0.05. Further substitution of vanadium in K-TTB decomposes to K-HTB and non-bronze phases. Keywords: Tungsten bronzes; Vanadium substituted bronze; Bronzoids. © 2012 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v4i2.9349 J. Sci. Res. 4 (2), 507-514 (2012)