bluuebunny/crossref_metadata_2025_split huggingface dataset:
BACE1 (Beta‐Secretase) Inhibitory Phenolic Acids and a Novel Sesquiterpenoid from Homalomena occulta
Authors: Tian Xiao‐Yan , Zhao Ying , Yu Shi‐Shan , Fang Wei‐Shuo 
Published: April 2010

AbstractFour phenolic acids, namely 2‐[(Z)‐heptadec‐11‐enyl]‐6‐hydroxybenzoic acid (1), 2‐[(6Z,9Z,12Z)‐heptadeca‐6,9,12‐trienyl]‐6‐hydroxybenzoic acid (2), 2‐[(9Z,12Z)‐heptadeca‐9,12‐dienyl]‐6‐hydroxybenzoic acid (3), and 2‐hydroxy‐6‐(12‐phenyldodecyl)benzoic acid (4), and one sesquiterpene, asperpenoid (5), were isolated from the 95% EtOH extract of the roots of Homalomena occulta, among which 1, 2, and 5 represent new compounds. Further, the phenolic acids 1–4 exhibited BACE1 (β‐secretase) inhibitory activity with IC50 values of 6.23±0.94, 6.28±0.63, 7.93±0.38, and 7.65±0.62 μM, respectively.
Antiprotozoal, Schistosomicidal, and Antimicrobial Activities of the Essential Oil from the Leaves of Baccharis dracunculifolia
Authors: Parreira Natállia A. , Magalhães Lizandra G. , Morais Denis R. , Caixeta Soraya C. , de Sousa João P. B. , Bastos Jairo K. , Cunha Wilson R. , Silva Márcio L. A. , Nanayakkara N. P. D. , Rodrigues Vanderlei , da Silva Filho Ademar A. 
Published: April 2010

AbstractBaccharis dracunculifolia DC. (Asteraceae), popularly known as ‘alecrim do campo’, is a native plant from Brazil used in folk medicine as febrifuge, anti‐inflammatory, antiseptic, and to treat skin sores. Also, B. dracunculifolia is the most important plant source of the Brazilian green propolis, which is recognized for its antiseptic and antiprotozoal activities. This study aimed at investigating the in vitro antiprotozoal, schistosomicidal, and antimicrobial activities of the essential oil from the leaves of B. dracunculifolia. The essential oil was obtained by hydrodistillation and analyzed by GC and GC/MS, which allowed the identification of 14 compounds, mainly oxygenated sesquiterpenes, such as (E)‐nerolidol (33.51%) and spathulenol (16.24%). The essential oil showed activity against promastigote forms of Leishmania donovani, with IC50 values of 42 μg/ml. The essential oil displayed high activity in the schistosomicidal assay, since all pairs of Schistosoma mansoni adult worms were dead after incubation with the essential oil (10, 50, and 100 μg/ml). B. dracunculifolia essential oil was neither cytotoxic against Vero cells, nor active in the antimicrobial and antiplasmodial assays.
Composition and Chemical Variability of Mentha suaveolens ssp. suaveolens and M. suaveolens ssp. insularis from Corsica
Authors: Sutour Sylvain , Bradesi Pascale , Casanova Joseph , Tomi Félix 
Published: April 2010

AbstractA detailed analysis of two essential oils from individual plants of Mentha suaveolens ssp. suaveolens growing wild in Corsica was carried out by combination of GC(RI), GC/MS, and 13C‐NMR analyses. One oil sample is characterized by the pre‐eminence of piperitenone oxide, and the second is dominated by piperitenone. In contrast, it was reported that the essential oil of M. suaveolens ssp. insularis, an endemic species to Corsica and Sardinia, contained pulegone and cis‐cis‐p‐menthenolide as main components. A principal‐component analysis (PCA) carried out on the composition of the essential oil of 59 individual plants of M. suaveolens sp. allowed the classification into three well‐defined groups. All the oil samples from Mentha suaveolens ssp. insularis belonged to the same group, while the oils from M. suaveolens ssp. suaveolens were distributed in the two other groups. The composition of the essential oil isolated from aerial parts of M. suaveolens ssp. has been shown to be an additional tool to differentiate the botanically close subspecies suaveolens and insularis.
The Future of Aminoglycosides: The End or Renaissance?
Authors: Houghton Jacob L. , Green Keith D. , Chen Wenjing , Garneau‐Tsodikova Sylvie 
Published: April 2010

AbstractAlthough aminoglycosides have been used as antibacterials for decades, their use has been hindered by their inherent toxicity and the resistance that has emerged to these compounds. It seems that such issues have relegated a formerly front‐line class of antimicrobials to the proverbial back shelf. However, recent advances have demonstrated that novel aminoglycosides have a potential to overcome resistance as well as to be used to treat HIV‐1 and even human genetic disorders, with abrogated toxicity. It is not the end for aminoglycosides, but rather, the challenges faced by researchers have led to ingenuity and a change in how we view this class of compounds, a renaissance.
Simultaneous 19F NMR Screening of Prolyl Oligopeptidase and Dipeptidyl Peptidase IV Inhibitors
Authors: Kichik Nessim , Tarragó Teresa , Giralt Ernest 
Published: April 2010

AbstractProlyl oligopeptidase (POP) and dipeptidyl peptidase IV (DPP IV) are serine proteases that belong to the same family of enzymes. These peptidases are relevant because of their association with the pathophysiology of serious illnesses, such as type 2 diabetes (DPP IV), and those related to cognitive disorders (POP). Several NMR‐based screening methods are being used to find and validate new hit scaffolds. In particular, 19F NMR‐based screening methods have proven to be powerful tools for the discovery and development of new inhibitors. Here we present an accurate and reliable 19F NMR‐based simultaneous assay that is used to screen for new selective POP and DPP IV inhibitors in compound mixtures. This activity assay consists of the simultaneous performance of POP and DPP‐IV 19F NMR activity assays in the presence of their fluorine‐containing substrates. Furthermore, the assays were conducted in the presence of 0.01 % v/v of Triton X‐100, which is a detergent that disrupts micelle formation, thereby preventing unspecific aggregate‐based inhibition. Finally, this 19F NMR methodology was applied to screen for ligands in plant extracts. Our results indicate that this method allows the simultaneous and accurate identification of selective POP and DPP IV inhibitors in these compound mixtures.
Giant splenic artery aneurysm: Managed in the cardiovascular catheterization laboratory using the modified neck remodeling technique
Authors: Pappy Reji , Sech Candice , Hennebry Thomas A. 
Published: April 2010

AbstractWe report the first case of coil embolization using the “modified neck remodeling technique” in the management of a splenic artery aneurysm. This technique was feasible due to the unique and complex anatomy of the aneurysm. This condition has been largely treated by vascular surgeons and interventional radiologists; however, this patient was referred to the interventional cardiologists for endovascular coiling. © 2010 Wiley‐Liss, Inc.
Occlusion of Sano conduit with the Amplatzer Vascular Plug: A reliable method for staged elimination of accessory pulmonary blood flow in single ventricle palliation
Authors: Gordon Brent M. , Hashmi Aijaz , Kuhn Micheal A. 
Published: April 2010

AbstractBackground: Staged palliative surgery is often required to regulate pulmonary and systemic blood flow in children with complex congenital heart disease. Accessory sources of pulmonary blood flow have been utilized to provide satisfactory pulmonary blood flow after Glenn anastomosis in select patients. Prolonged exposure to increased flow can lead to elevated pulmonary arterial pressures and volume loading of the ventricle, potentially limiting candidacy for Fontan completion. Objective: To review the feasibility, technique, and outcome of transcatheter closure of the Sano conduit utilizing the Amplatzer Vascular Plug (AVP). Methods: All patients who underwent device closure of the Sano conduit with an AVP were reviewed retrospectively. Patient demographics, indications, procedural details, and patient outcomes were reviewed. Hemodynamic changes before and after occlusion of the Sano conduit were compared. A P value < 0.05 was considered significant. Results: Between 2005 and 2009, 11 male patients underwent Sano occlusion with an AVP. Average weight was 8.8 ± 2.2 kg. The Sano was occluded from both antegrade (n = 6) and retrograde (n = 5) approaches. Arterial saturation and mean pulmonary artery pressure both decreased significantly after Sano occlusion [86.9 ± 4.9% to 82.6 ± 4.9% (P < 0.001) and 14.1 ± 5 mm Hg to 12.8 ± 4 mm Hg (P < 0.05), respectively]. Conduit diameter averaged 3.6 mm (range 3.1–4.4) 13 months after Stage I palliation. The conduit was closed using a 6 mm AVP in nine patients and a 4 mm AVP in the other two. The ratio of AVP size to conduit diameter was 1.5 ± 0.27. There were no procedural complications and all patients at least 2 years of age have undergone Fontan completion. Conclusions: The Sano conduit can be left open in select patients who do not tolerate closure after Glenn anastomosis. It can be closed safely and effectively using the AVP. © 2010 Wiley‐Liss, Inc.
Improving myocardial salvage in late presentation acute ST‐elevation myocardial infarction with proximal embolic protection
Authors: Larose Eric , Tizon‐Marcos Helena , Rodés‐Cabau Josep , Rinfret Stéphane , Déry Jean‐Pierre , Nguyen Can M. , Gleeton Onil , Boudreault Jean‐Rock , Roy Louis , Noël Bernard , Proulx Guy , Rouleau Jacques , Barbeau Gérald , De Larochellière Robert , Bertrand Olivier F. 
Published: April 2010

AbstractBackground: Late‐presenting ST‐elevation myocardial infarction (STEMI) patients possess larger, more organized coronary thrombus leading to greater ventricular remodeling and arrhythmia despite angioplasty and pharmacological therapies. We hypothesized that myocardial injury would be reduced in late STEMI by proximal embolic protection (PEP). Methods: 31 patients with first STEMI 12–24 hr after pain onset and TIMI 0–1 flow were treated with or without PEP (cohort design matched for age, gender, and infarct‐related artery). Contrast‐enhanced magnetic resonance determined myocardial function, area at risk, necrosis, salvaged myocardium, and arrythmogenic peri‐infarct region. Clinical follow‐up was performed. Results: Pain to balloon time was 18 hr (95% CI 15.5–21.2 h), and Q waves were present in 87%. Angioplasty was performed with PEP in 15 and without in 16. Left ventricular (LV) volumes and ejection fraction were similar (EF 46.9% vs. 49.0% without PEP, P = 0.9). Although myocardial necrosis was similar (32.5 vs. 37.3% of LV, P = 0.3), PEP improved microvascular obstruction (8.7 vs. 11.2% of LV, P = 0.02) salvaged myocardium (39.6% vs. 29.6% of area at risk, P = 0.001), and the peri‐infarct region (20.9 vs. 29.6% of infarct, P < 0.0001). On multivariate analysis, the use of PEP was an independent predictor of decreased arrythmogenic peri‐infarct region and greater myocardial salvage. Conclusion: In this pilot study, PEP improved myocardial salvage and the arrythmogenic peri‐infarct region in late‐presentation STEMI. Randomized trials are required to assess the clinical impact of improving salvaged myocardium and the peri‐infarct region with PEP. © 2010 Wiley‐Liss, Inc.
Cardiac catheterization in patients with end‐stage liver disease: Safety and outcomes
Authors: Pillarisetti Jayasree , Patel Pavan , Duthuluru Sowjanya , Roberts Jenny , Chen Warren , Genton Randall , Wiley Mark , Candipan Robert , Tadros Peter , Gupta Kamal 
Published: April 2010

AbstractIntroduction: Patients with end‐stage liver disease (ESLD) awaiting transplant are at increased risk of bleeding. Nevertheless, these patients routinely undergo cardiac catheterization for various indications. Safety and outcomes of cardiac catheterization in these patients are not well reported. Methods: In a case–control study 43 patients with ESLD who underwent angiography for liver transplant work‐up were compared to 43 age and gender‐matched controls with no liver dysfunction. In‐hospital outcomes and procedural variables were compared. Results: Patients with ESLD had a lower baseline hemoglobin (12.1 ± 2.1 vs. 13.7 ± 1.8, P < 0.0005), lower platelet counts (86.8 ± 66 vs. 247 ± 80, P < 0.0001) and higher international normalized ratio (INR) (1.4 ± 0.2 vs. 1.1 ± 0.2, P < 0.0001) than controls. Among ESLD group, five (11.6%) patients received platelet transfusions, one received blood transfusion, and three patients (7%) with INR > 1.6 received fresh frozen plasma (FFP) compared with none in the control group. Smaller size (four French) vascular sheaths were used more frequently in the group with ESLD (16% vs. 4%, P = 0.04). There were no significant vascular or bleeding complications in either group. Conclusions: Elective cardiac catheterization can be safely performed in patients with ESLD with outcomes (vascular and bleeding complications, length of hospital stay and in‐hospital mortality) similar to patients without liver disease despite significant thrombocytopenia and elevated INR in patients with ESLD. Practices such as platelet transfusion for platelets <60,000 μL, prophylactic FFP transfusion for INR ≥≥ 1.6, less frequent use of antiplatelet therapy and more frequent use of smaller vascular sheaths may have contributed to the safety of cardiac catheterization in ESLD patients. © 2010 Wiley‐Liss, Inc.
First‐in‐man use of a tapered endovascular stent graft for treatment of aneurysm after coarctation repair
Authors: Nietlispach Fabian , Leipsic Jonathon , Wijesinghe Namal , Webb John G. , Carere Ronald G. 
Published: April 2010

AbstractObjectives: Endovascular stenting of aneurysms late after surgical repair of coarctation may have to deal with marked changes in aortic diameter proximal and distal to the aneurysm. We report our first‐in‐man successful use of a custom‐made tapered (variable diameter) covered stent. Methods: The aneurysm was 42 mm in diameter with a length of 40 mm. On MRI, the aorta measured 19.6 mm proximal and 13.3 mm distal to the aneurysm. The aim was to oversize the stent by 10–20%. A covered Cheatham‐platinum stent was designed so that cranial portion of the stent would expand to 22 mm and the caudal portion to 15 mm with a length of 8.5 cm when fully inflated. The stent was mounted on a balloon‐in‐balloon delivery system and was delivered through an 18 F femoral arterial sheath. Rapid‐pacing technique was used for deployment. Results: The stent was successfully deployed without complications. After deployment, the stent diameter measured 21.2 mm cranially and 15.6 mm caudally. A mild distal endoleak due to inadequate fixation of the stent graft was resolved by post dilation expanding the stent diameter to 22.1 mm and 15.9 mm, respectively. The femoral access site was closed using two percutaneous closure devices and the patient discharged the day after the procedure. Follow‐up CT‐angiography showed continued successful exclusion of the aneurysm. Conclusions: A new custom‐made balloon expandable covered stent‐design enabled successful treatment of an aortic aneurysm. This design may offer greater potential for more favorable initial angiographic results and potentially long‐term outcomes due to superior apposition to the aortic wall. © 2010 Wiley‐Liss, Inc.
Management of implant failure during transcatheter aortic valve implantation
Authors: Ussia Gian Paolo , Barbanti Marco , Immè Sebastiano , Scarabelli Marilena , Mulè Massimiliano , Cammalleri Valeria , Aruta Patrizia , Pistritto Anna Maria , Capodanno Davide , Deste Wanda , Di Pasqua Maria Concetta , Tamburino Corrado 
Published: April 2010

AbstractBackground: Transcatheter aortic valve implantation (TAVI) is an emerging alternative to palliative medical therapy for nonsurgical patients with severe aortic stenosis. There is a paucity of detailed data on the management and outcome of complications related to the sub‐optimal deployment of the prosthesis. We appraised the incidence and management of early implant failure occurring during TAVI. Methods: Of 110 patients who underwent TAVI using the third generation 18‐French CoreValve ReValving System (Medtronic, MN) in our Institution between June 2007 and January 2010, we identified those experiencing early implant failure and reported on their management and clinical outcome. The primary endpoint was the incidence of major adverse cardiovascular and cerebrovascular event (MACCE) at 30 days and mid‐term follow up. Results: Early implant failure occurred in 18 of 110 patients (16.3%). The most common cause was prosthesis under‐expansion conditioning moderate to severe peri‐valvular leak (44.4%). Prosthesis deployment too low or too high with respect to the aortic annulus leading to severe peri‐valvular leak occurred in 22.2% and 5.5% of patients, respectively. Need of valve retrieve after the first attempt of deployment occurred in four cases (22.2%). Prosthesis embolization in the ascending aorta occurred in 5.5% of patients who experienced early implant failure. All implant failure cases were managed percutaneously with gain in aortic valve area from 0.44 ± 0.17 to 1.28 ± 0.27 cm2 (P < 0.001), decrease of mean transaortic gradient from 55.00 ± 19.51 to 11.58 ± 5.91 mmHg (P < 0.001) and no MACCE at 30 days. After 11 ± 6 months, MACCE occurred cumulatively in two patients (11.1%). Conclusions: Early implant failure can complicate the TAVI procedure with the CoreValve system, but it can be managed safely and effectively with bailout transcatheter techniques, avoiding surgery, with good early and mid‐term clinical and echocardiographic results. © 2010 Wiley‐Liss, Inc.
Chemoselective Hydrogenolysis of Tetrahydropyran‐2‐methanol to 1,6‐Hexanediol over Rhenium‐Modified Carbon‐Supported Rhodium Catalysts
Authors: Chen Kaiyou , Koso Shuichi , Kubota Takeshi , Nakagawa Yoshinao , Tomishige Keiichi 
Published: April 2010

AbstractModification of Rh/C with Re species enabled chemoselective hydrogenolysis of tetrahydropyran‐2‐methanol to 1,6‐hexanediol. In particular, the Rh–ReOx/C (Re/Rh ratio=0.25) catalyst gave a high yield of 1,6‐hexanediol (84 %) and showed a very low activity for overhydrogenolysis to 1‐hexanol. Using the same catalyst in the hydrogenolysis of tetrahydrofurfuryl alcohol also gave a high yield of 1,5‐pentanediol (94 %). Characterization results indicate the formation of ReOx clusters attached on the surface of Rh metal particles. This can cause the synergy between ReOx and Rh, and the tetrahydropyran‐2‐methanol hydrogenolysis proceeds on the interface between Rh metal surface and attached ReOx species.
Minimal Hydrolases: Organocatalytic Ring‐Opening Polymerizations Catalyzed by Naturally Occurring Carboxylic Acids.
Authors: Domínguez de María Pablo 
Published: April 2010

AbstractOrganocatalysis has emerged during the last decade as a concept with a significant number of synthetic applications. Important driving forces for this growth are that organocatalytic strategies often operate at rather mild reaction conditions, with reduced waste formation, and that processes may lead to high selectivities. In this area, some organocatalytic examples have been reported in the field of ring‐opening polymerizations of lactones, as well as for some (trans)esterifications. These reactions are catalyzed by organic molecules such as α‐hydroxycarboxylic acids, amino acids, 4‐(dimethylamino)pyridine, N‐heterocyclic carbenes, guanidines, or bifunctional thiourea–amines. With regard to α‐hydroxycarboxylic acids, it is believed that these organocatalysts catalyze reactions in a similar fashion to hydrolases, such as lipases or esterases, thus leading to valuable biomimetic catalytic concepts. Importantly, advantages that are inherent to enzymatic catalysis can be combined with a broader range of potential reaction conditions (e.g., solvent‐free), or exploited for the efficient and selective (tailored) modification of synthetically challenging substrates (e.g., ring‐opening polymerizations with cellulose and other polysaccharides as initiators). Furthermore, α‐hydroxycarboxylic acids are readily accessible by biotechnological routes such as fermentation, are nontoxic, and easy to apply. Herein, the uses of these “minimal hydrolases” in catalyzing ring‐opening polymerizations and transesterifications are categorized and discussed. Albeit still at the level of proof‐of‐principle, many interesting practical applications can be conducted according to these biomimetic routes.
Deconvolution of femtosecond time‐resolved spectroscopy data in multivariate curve resolution. Application to the characterization of ultrafast photo‐induced intramolecular proton transfer
Authors: Mouton Nicolas , Sliwa Michel , Buntinx Guy , Ruckebusch Cyril 
Published: April 2010

AbstractIn femtosecond absorption spectroscopy, deconvolution of the measured kinetic traces is still an important issue as photochemical processes that may possess shorter characteristic times than the time resolution of the experiment are usually considered. In this work, we propose to perform deconvolution of the time‐dependent concentration profiles extracted from multivariate curve resolution (MCR) applied to spectrokinetic data. The profiles are fitted with a model function including a description of the instrumental response function (IRF) of the experiment. The method combines the potential benefits of soft‐modeling data analysis with the ones of hard‐modeling for parameter estimation. The potential of the method is demonstrated first analyzing five synthetic data sets for which IRF of different widths are simulated. It is then successfully applied to resolve femtosecond UV‐visible transient absorption spectroscopy data investigating the photodynamics of salicylidene aniline, a photochromic molecule of wide interest. Considering a time resolution of 150 fs for the IRF, a characteristic time of 45 fs is recovered for the first step of the photo‐induced process which consists of an ultrafast intramolecular proton transfer. Our results also confirm the existence of an intermediate species with a characteristic time of 240 fs. Copyright © 2010 John Wiley & Sons, Ltd.
Borane and Borohydride Complexes of the Rare‐Earth Elements: Synthesis, Structures, and Butadiene Polymerization Catalysis
Authors: Jenter Jelena , Meyer Nils , Roesky Peter W. , Thiele Sven K.‐H. , Eickerling Georg , Scherer Wolfgang 
Published: April 2010

AbstractThe reaction of potassium 2,5‐bis[N‐(2,6‐diisopropylphenyl)iminomethyl]pyrrolyl [(dip2‐pyr)K] with the borohydrides of the larger rare‐earth metals, [Ln(BH4)3(thf)3] (Ln=La, Nd), afforded the expected products [Ln(BH4)2(dip2‐pyr)(thf)2]. As usual, the trisborohydrides reacted like pseudohalide compounds forming KBH4 as a by‐product. To compare the reactivity with the analogous halides, the dimeric neodymium complex [NdCl2(dip2‐pyr)(thf)]2 was prepared by reaction of [(dip2‐pyr)K] with anhydrous NdCl3. Reaction of [(dip2‐pyr)K] with the borohydrides of the smaller rare‐earth metals, [Sc(BH4)3(thf)2] and [Lu(BH4)3(thf)3], resulted in a redox reaction of the BH4− group with one of the Schiff base functions of the ligand. In the resulting products, [Ln(BH4){(dip)(dip‐BH3)‐pyr}(thf)2] (Ln=Sc, Lu), a dinegatively charged ligand with a new amido function, a Schiff base, and the pyrrolyl function is bound to the metal atom. The by‐product of the reaction of the BH4− anion with the Schiff base function (a BH3 molecule) is trapped in a unique reaction mode in the coordination sphere of the metal complex. The BH3 molecule coordinates in an η2 fashion to the metal atom. The rare‐earth‐metal atoms are surrounded by the η2‐coordinated BH3 molecule, the η3‐coordinated BH4− anion, two THF molecules, and the nitrogen atoms from the Schiff base and the pyrrolyl function. All new compounds were characterized by single‐crystal X‐ray diffraction. Low‐temperature X‐ray diffraction data at 6 K were collected to locate the hydrogen atoms of [Lu(BH4){(dip)(dip‐BH3)‐pyr}(thf)2]. The (DIP2‐pyr)− borohydride and chloride complexes of neodymium, [Nd(BH4)2(dip2‐pyr)(thf)2] and [NdCl2(dip2‐pyr)(thf)]2, were also used as Ziegler–Natta catalysts for the polymerization of 1,3‐butadiene to yield poly(cis‐1,4‐butadiene). Very high activities and good cis selectivities were observed by using each of these complexes as a catalyst in the presence of various cocatalyst mixtures.