bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Validation Study of the Canadian Organ Replacement Register
Authors: Moist Louise M. , Richards Heather A. , Miskulin Dana , Lok Charmaine E. , Yeates Karen , Garg Amit X. , Trpeski Lilyanna , Chapman Ann , Amuah Joseph , Hemmelgarn Brenda R. 
Published: January 2011

Summary

Background and objectives
Accurate and complete documentation of patient characteristics and comorbidities in renal registers is essential to control bias in the comparison of outcomes across groups of patients or dialysis facilities. The objectives of this study were to assess the quality of data collected in the Canadian Organ Replacement Register (CORR) compared with the patient's medical charts.

Design, setting, participants, & measurements
This cohort study of a representative sample of adult, incident patients registered in CORR in 2005 to 2006 examined the prevalence, sensitivity, specificity, positive and negative predictive values, and κ of comorbid conditions and agreement in coding of patient demographics and primary renal disease between CORR and the patient's medical record. The effect of coding variation on patient survival was evaluated.

Results
Medical records on 1125 patients were reviewed. Agreement exceeded 97% for health card number, date of birth, and sex and 71% (range 46.6 to 89.1%) for the primary renal disease. Comorbid conditions were under-reported in CORR. Sensitivities ranged from 0.89 (95% confidence interval 0.80, 0.92) for hypertension to 0.47 (0.38, 0.55) for peripheral vascular disease. Specificity was >0.93 for all comorbidities except hypertension. Hazard ratios for death were similar whether calculated using data from CORR or the medical record.

Conclusions
Comorbid conditions are under-reported in CORR; however, the associated risks of mortality were similar whether using the CORR data or the medical record data, suggesting that CORR data can be used in clinical research with minimal concern for bias.
Breast Arterial Calcification
Authors: Duhn Valerie , D'Orsi Ellen T. , Johnson Samuel , D'Orsi Carl J. , Adams Amy L. , O'Neill W. Charles 
Published: January 2011

Summary

Background and objectives
Because previous studies have not distinguished between intimal (atherosclerotic) and medial vascular calcification, the prevalence and clinical significance of either condition in chronic or end-stage kidney disease (CKD or ESKD) are unknown. We hypothesized that breast arterial calcification (BAC) is exclusively medial and that mammography can serve as a useful marker of generalized medial calcification in CKD and ESKD.

Design, setting, participants, & measurements
Arterial calcification was identified histologically in breast tissue or visually in mammograms and radiographs of extremities from patients with CKD or ESKD.

Results
Medial calcification but no intimal calcification was present in all 16 specimens from patients with CKD or ESKD. In 71 women with ESKD, BAC was present on mammograms in 63% compared with 17% in women without renal insufficiency matched for age, race, and diabetes (P < 0.001). Age and ESKD duration were significant, independent predictors of BAC. BAC was also present in 36% of mammograms from the same patients performed 5.5 ± 0.7 years before the onset of ESKD (P < 0.05 versus control) but in only 14% of patients with stage 3 CKD. Comparison of mammograms and extremity radiographs revealed that BAC was present in over 90% of patients with peripheral arterial calcification (PAC), and PAC was observed in less than 6% of patients without BAC.

Conclusions
BAC is a specific and useful marker of medial vascular calcification in CKD, and its prevalence is markedly increased in ESKD and advanced CKD.
The 25-Year Cumulative Incidence of Lower Extremity Amputations in People With Type 1 Diabetes
Authors: Sahakyan Karine , Klein Barbara E.K. , Lee Kristine E. , Myers Chelsea E. , Klein Ronald 
Published: January 2011

OBJECTIVE
To examine the 25-year cumulative incidence of lower-extremity amputation (LEA) in people with type 1 diabetes.

RESEARCH DESIGN AND METHODS
Cumulative incidence of LEA was ascertained in Wisconsin Epidemiologic Study of Diabetic Retinopathy participants (n = 943) using the Kaplan-Meier approach accounting for competing risk of death. Relationships of baseline characteristics with incidence of LEA were explored using a proportional hazards approach with discrete linear regression modeling.

RESULTS
The overall 25-year incidence of LEA was 10.1%. In multivariate analyses (results reported as odds ratio; 95% CI), being male (3.90; 2.29–6.65), heavy smoking (2.07; 1.11–3.85), having hypertension (3.36; 1.91–5.93), diabetic retinopathy (2.62; 1.13–6.09), neuropathy (1.68; 1.02–2.76), and higher HbA1c (per 1% 1.40; 1.24–1.58) were independently associated with the incidence of LEA.

CONCLUSIONS
Our results show a high 25-year incidence of LEA and suggest that glycemic control and blood pressure control and preventing heavy smoking may result in reduction in its incidence.
Underdiagnosed and Undertreated Depression Among Racially/Ethnically Diverse Patients With Type 2 Diabetes
Authors: Sorkin Dara H. , Ngo-Metzger Quyen , Billimek John , August Kristin J. , Greenfield Sheldon , Kaplan Sherrie H. 
Published: January 2011

OBJECTIVE
To examine racial/ethnic differences in the prevalence of depressive symptoms and in provider recognition of depression among Latino, Asian, and non-Hispanic white patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS
Patients (n = 1,209) with type 2 diabetes were recruited from five university-affiliated primary care clinics for an observational study.

RESULTS
Vietnamese American (133, 59.4%) and Mexican American (351, 50.2%) patients were more likely to report symptoms consistent with clinical depression (Center for Epidemiological Studies Depression [CES-D] scale score ≥22) than non-Hispanic whites (119, 41.6%; F [2, 1206] = 8.05, P &lt; 0.001). Despite comparable diabetes care, Vietnamese and Mexican patients with high depressive symptoms were less likely to be diagnosed and treated than non-Hispanic whites (all P values &lt; 0.001). Minority patients who reported low levels of trust in their provider were less likely to have been diagnosed or treated for depression (adjusted odds ratio 0.65, 95% CI 0.44–0.98, P &lt; 0.05).

CONCLUSIONS
Innovative strategies are needed to improve recognition of depressive symptoms in minority patients.
« El Castillo interior » y el « Arte de la memoria ».
Authors: Gerli M 
Published: January 2011

« El castillo interior » et V « Arte de la memoria ».
L'aspect iconographique du castillo interior de sainte Thérèse révèle une influence de Vars memorativa, c'est-à-dire de la méthode utilisée dans les cultures et sociétés de tradition orale pour structurer la connaissance et faciliter la mémorisation. Sainte Thérèse employa la méthodologie de l'art de la mémoire pour organiser son livre et pour garantir ainsi le souvenir des voies de sa nouvelle spiritualité. Le propos du Castillo interior est de fixer la doctrine carmélite de l'oraison dans la mémoire de ses lecteurs et d'offrir une exposition claire et cohérente des croyances de la secte de sainte Thérèse. Au-delà de la piété et la conviction, il y a dans le fond de cet ouvrage une propagande réformiste qui se manifeste par un procédé rigoureux et délibéré de composition.
La formación de una biblioteca de libros prohibidos en la España isabelina. [Luis Usoz y Río, importador clandestino de libros protestantes (1841-1850)]
Authors: Bautista Vilar Juan 
Published: January 2011

En el segundo tercio del siglo XIX don Luis Usoz y Río (1805-1865) formó la más importante biblioteca de autores heterodoxos que ha existido jamás en España : 11.357 volúmenes. Este fondo bibliográfico fue donado en 1873 por la viuda de Usoz a la Biblioteca Nacional de Madrid, donde se conserva actualmente.
El presente artículo, elaborado a base de una documentación inédita, reconstruye, día a día, el proceso de formación de esa biblioteca y, al propio tiempo, ilumina un tema poco conocido : la importación clandestina de libros prohibidos en la España contemporánea.
Une énigme géomorphologique : les limons d'Isturits (Pyrénées-Atlantiques)
Authors: Viers Georges 
Published: January 2011

RÉSUMÉ
Les blocs siliceux (calcédoine et quartz) des limons d'Isturits (Pyrénées- Atlantiques, France) sont des meulières. La silicification s'est opérée en milieu calcaire dans un poljé à inondation temporaire grâce à des apports de silice venus de l'Est (Grès de Mixe) et du Sud (gneiss d'Urzuia). Les limons datent du Quaternaire moyen (Mindel).
Le karst d'Italie Centrale
Authors: Raffy Jeannine 
Published: January 2011

ZUSAMMENFASSUNG
Die entwicklung des Karstes in Mittelitalien wurde durch die gemäszigl warmen und feuchien Paleo-Klimas, dit während des Pleisiozäns herrschten, begünstigt. Seine Entwicklung, die auf den beiden Hängen des Apennin verschieden ist, erktärt sich durch eine zeitlich wie räumlisch ungleiche Versteilung der normalen Verwerfungen und offenen Spätlen, die damit verbunden sind. Das Sickern des Wassers durch eine dünne Schicht verwillerter vulkanischer Aschen fördert die Auflösungs prozesse.
Problèmes hydrologiques et hydrochimiques du karst du Liban central
Authors: Hakim Bahzad 
Published: January 2011

SUMMARY
The wealth of karst in central Lebanon has permitted the study of the perched aquifer (of the high cenomanien plateau of Kesrouane) in comparison to the Barred limestone aquifer (of the low and middle mountains) and the cretaceous aquifer of the littoral area that contributes of the alimentation of powerful submarine springs.
The study of the « ablation cycle » leads to the valuation of the dissolved contents of the meteoric waters, the streaming, percolated, infiltred waters, as well as of the subterranean rivers and the karstic springs. The chimical analyse of rain waters, as soon as they arrive on a karstic reception basin and stream on a distance of 100 meters, gives important results.
Expression of CD44s and CD44v6 in Lung Cancer and Their Correlation with Prognostic Factors
Authors: Afify Alaa M. , Tate Stacey , Durbin-Johnson Blythe , Rocke David M. , Konia Thomas 
Published: January 2011

Background CD44, a transmembrane glycoprotein receptor, plays a major role in tumor progression and metastasis. Objective: To evaluate the expression of CD44 standard (CD44s) and its variant 6 (CD44v6) in normal and neoplastic lung tissue and correlate it with prognostic factors in lung cancer. Methods The study included 52 non-small cell lung carcinomas (NSCLC) (21 squamous cell carcinomas and 31 adenocarcinomas), 15 small cell lung carcinomas (SCLC) and 8 carcinoid tumors. Expression of CD44s and CD44v6 was evaluated by immunohistochemistry and correlated with lung cancer prognostic factors. Results All squamous cell carcinomas expressed both CD44s and CD44v6. Adenocarcinomas expressed CD44s in 39% of cases and CD44v6 in 45%. Carcinoid tumors expressed only CD44s in 88% of cases. All SCLCS were negative for both CD44s and CD44v6. A restricted panel consisting of CD44s and CD44v6 will discriminate NSCLC from SCLC with a sensitivity of 67% and a specificity of 100%. In adenocarcinoma CD44s expression was significantly correlated with lymph node metastases (p=0.007) while CD44v6 expression was more significantly associated with tumor size (p=0.0032). Conclusions CD44s and CD44v6 are expressed in certain types of lung cancer. In adenocarcinoma CD44s and CD44v6 expression is significantly correlated with lymph node metastases and tumor size.
Modeling of heat recovery from a steam‐gas mixture in a high‐temperature sorption process
Authors: Jeong Kwangkook , Sircar Shivaji , Caram Hugo S. 
Published: January 2011

AbstractA high pressure condenser is considered to remove water vapor as well as recover heat from the desorbed steam—CO2 gas mixture in a novel sorption enhanced reaction process. It is possible to have water condensation at the gas side as well as water evaporation at the coolant water side because of large temperature difference between the hot and cold side. A model of heat and mass transfer and phase change was developed to understand the complex phenomena associated with the simultaneous condensation and evaporation taking place in the unit. A finite difference method was used to solve the boundary value problem. Additional insight was obtained by describing the operating lines and equilibrium condition in an enthalpy diagram. The model was used to explore the performance in terms of the heat recovery. The heat recovery was best at the beginning of the process when the superheated steam was generated. © 2011 American Institute of Chemical Engineers AIChE J, 2012
The Compromise Effect in Choosing for Others
Authors: Chang Chung‐Chau , Chuang Shih‐Chieh , Cheng Yin‐Hui , Huang Tien‐Ying 
Published: January 2011

ABSTRACTMost research into the compromise effect focuses on cognitive factors related to choosing for oneself. However, there are daily opportunities to make choices for others, from helping friends to buy merchandise to choosing souvenirs for relatives. Although it is a common practice, choosing for others is rarely discussed in the literature. Hence, this research is directed to determine whether (i) the compromise effect is greater for people choosing for others with whom one has a distant relationship compared to choosing for themselves, (ii) the decision maker's susceptibility to interpersonal relationships, accountability, and anticipated regret moderate the relationship between choosing for others versus choosing for themselves and the compromise effect, and (iii) the confidence of the decision maker mediates the relationship between deciding for others and the compromise effect. Five hypotheses are proposed and they are supported by the results from four experiments. Copyright © 2011 John Wiley & Sons, Ltd.
The Value of Task Conflict to Group Decisions
Authors: Boyle Peter J. , Hanlon Dennis , Russo J. Edward 
Published: January 2011

ABSTRACTWe tested the ability of task conflict to improve the quality of decisions made by four‐person groups. In a choice between two entrepreneurial investments, conflict was created by endowing group members with a preference for either one investment or the other. Because the decision was subjective, decision quality was necessarily judged by a process criterion, the reduction in the biased evaluation of new information to support the leading alternative. Groups in which conflict was installed exhibited less bias than individuals, who themselves exhibited less bias than groups without such conflict. Regardless of whether conflict was installed, groups that reached an early consensus exhibited the greatest information bias, while groups that experienced sustained conflict exhibited the least. Before achieving consensus, information bias was not significantly different from zero, but then rose steadily after that agreement. This result identifies one specific mechanism by which conflict can improve the process of group decisions. Copyright © 2011 John Wiley & Sons, Ltd.
Hydrodynamics of a Tapered Bubble Column
Authors: Bandyopadhyay A. , Biswas M. N. 
Published: January 2011

AbstractThe hydrodynamic behavior of a single‐stage tapered bubble column using an air‐water two‐phase system has been studied. The experimental results indicate that the holdup increases with increasing superficial gas velocity and bubble slip velocity, while it remains constant with increasing superficial liquid velocity. The gas flow rate has a subtle effect on pressure drop owing to the dynamic pressure recovery stemming from the increase in flow area in the axial direction. The results further suggest that the tapered bubble column shows higher holdup with lower energy dissipation than the conventional bubble columns under similar hydrodynamic conditions. The experimental values of the holdup are in excellent agreement with the well‐known Akita and Yoshida correlation available in the existing literature. Also, the performance of the tapered system has been shown to be much better than that of conventional columns under similar conditions in water/alkaline scrubbing of fly ash and SO2 either alone or in combination.
Lung cancer mortality risk among breast cancer patients treated with anti‐estrogens
Authors: Bouchardy Christine , Benhamou Simone , Schaffar Robin , Verkooijen Helena M. , Fioretta Gerald , Schubert Hyma , Vinh‐Hung Vincent , Soria Jean‐Charles , Vlastos Georges , Rapiti Elisabetta 
Published: January 2011

AbstractBACKGROUND:The Women's Health Initiative randomized clinical trial reported that menopausal hormone therapy increases lung cancer mortality risk. If this is true, use of anti‐estrogens should be associated with decreased lung cancer mortality risk. The authors compared lung cancer incidence and mortality among breast cancer patients with and without anti‐estrogen therapy.METHODS:Our study included all 6655 women diagnosed with breast cancer between 1980 and 2003 and registered at the Geneva Cancer Registry. Among these women, 46% (3066) received anti‐estrogens. All women were followed for occurrence and death from lung cancer until December 2007. The authors compared incidence and mortality rates among patients with and without anti‐estrogens with those expected in the general population by Standardized Incidence Ratios (SIRs) and Standardized Mortality Ratios (SMRs).RESULTS:After a total of 57,257 person‐years, 40 women developed lung cancer. SIRs for lung cancer were not significantly decreased among breast cancer patients with and without anti‐estrogens (0.63, 95% confidence intervals [CI], 0.33‐1.10; and 1.12, 95% CI, 0.74‐1.62, respectively) while SMR was decreased among women with anti‐estrogens (0.13, 95% CI, 0.02‐0.47, P<.001) but not for women without anti‐estrogens (0.76, 95% CI, 0.43‐1.23).CONCLUSIONS:Compared with expected outcomes in the general population, breast cancer patients receiving anti‐estrogen treatment for breast cancer had lower lung cancer mortality. This study further supports the hypothesis that estrogen therapy modifies lung cancer prognosis. Cancer 2011. © 2011 American Cancer Society.
Usage of erythropoiesis‐stimulating agents in cancer patients at an academic cancer center and experience with specific care management tools for anemia
Authors: Ferrajoli Alessandra , Buzdar Aman U. , DeJesus Yvette , Cheng Lee , Michaud Laura B. , Rodriguez Maria A. 
Published: January 2011

AbstractBACKGROUND:In 2007, the US Food and Drug Administration (FDA) issued regulatory alerts for use of erythropoiesis‐stimulating agents (ESAs) in cancer patients with anemia after clinical trials and meta‐analysis data found that high ESA doses were associated with adverse outcomes in patients. In response to these findings, specific patient management tools for anemia (consisting in an algorithm and prescribing order set) were developed by a multidisciplinary team at The University of Texas MD Anderson Cancer Center.METHODS:A retrospective study consisted of 7117 patients aged 18 years and older with cancer malignancies who had received an ESA between January 2006 and December 2008 at MD Anderson. Changes in utilization of ESAs and packed red blood cells (PRBCs) were evaluated.RESULTS:The number of ESA doses dispensed each month decreased by 83% from January 2006 to December 2008 (P < .01), and the number of patients who received ESAs decreased by 80% (P < .01). The number of dispensed ESA doses for hemoglobin (Hb) levels ≥12 g/dL decreased significantly from 4% to 0% (P < .01), and the number for ≥10 g/dL decreased from 44% to 12% (P < .01). The PRBC transfusion rate remained stable in solid tumor patients (P > .05) but increased from 7% to 9% (P < .05) in patients with hematologic malignancies.CONCLUSIONS:The authors summarized their experience with use of ESAs in a tertiary oncology center. The implementation of their patient management tools for anemia might have facilitated the observed change at MD Anderson Cancer Center. Cancer 2011. © 2011 American Cancer Society.
The impact of symptom interference using the MD Anderson Symptom Inventory‐Brain Tumor Module (MDASI‐BT) on prediction of recurrence in primary brain tumor patients
Authors: Armstrong Terri S. , Vera‐Bolanos Elizabeth , Gning Ibrahima , Acquaye Alvina , Gilbert Mark R. , Cleeland Charles , Mendoza Tito 
Published: January 2011

AbstractBACKGROUND:Tumor grade, age, extent of resection, and performance status are established prognostic factors for survival in primary brain tumor (PBT) patients. Development of disease‐related symptoms is predictive of tumor recurrence in other cancers but has not been reported in the PBT population.METHODS:A cross‐sectional sample of 294 PBT patients participated. Progression was based on the radiologist report of the magnetic resonance imaging (MRI). The relation of clinical variables (age, extent of resection, tumor grade, and Karnofsky performance status [KPS]) and MD Anderson Symptom Inventory‐Brain Tumor Module (MDASI‐BT) mean symptom and interference subscales with progression was examined using logistic regression.RESULTS:The study enrolled more men (60%, n = 175); median age was 46 years. The majority had less than a gross total resection (n = 186, 64%), and a good KPS (KPS ≥ 90) (N = 208). The majority had a grade 3 or 4 tumor (n = 199) and 24% of patients had recurrence. Tumor grade and activity‐related interference were significantly related to progression. Patients with tumor grade 4 were 2.4 times more likely to have recurrence (95% CI, 1.2‐5.; P < .015). Patients with significant (ratings of ≥5) activity‐related interference were 3.8 times more likely to have recurrence (95% CI, 2.14‐6.80; P < .001). Mean activity‐related score was 4.8 for those with progression on MRI and 2.2 for those with stable disease.CONCLUSIONS:Significant activity‐related interference and tumor grade were associated with recurrence but not KPS, age, or extent of resection. These results provide preliminary support for the use of symptom interference in assessment of disease status. Because the authors used a cross‐sectional sample, future studies evaluating change over time are needed. Cancer 2011. © 2011 American Cancer Society.
Using breast cancer quality indicators in a vulnerable population
Authors: Chen Formosa , Puig Melissa , Yermilov Irina , Malin Jennifer , Schneider Eric C. , Epstein Arnold M. , Kahn Katherine L. , Ganz Patricia A. , Gibbons Melinda Maggard 
Published: January 2011

AbstractBACKGROUND:Adherence to quality indicators may be especially important to disease‐specific outcomes for uninsured, vulnerable patients. The objective of this study was to measure adherence to National Initiative for Cancer Care Quality (NICCQ) breast cancer quality indicators in a public hospital and compare performance to published rates in a previously collected 5‐city cohort.METHODS:One hundred five consecutive, newly diagnosed, stage I‐III, breast cancer patients at a public hospital (from 2005 to 2007) were identified. Adherence rates to 31 quality indicators were measured by using medical record abstraction. Rates were calculated for individual indicators, aggregated domains, and components of care and were compared with the 5‐city cohort results by using a 2‐sided test of proportions.RESULTS:Overall adherence to the NICCQ indicators at the public hospital was 82%, versus 86% in the 5‐city cohort. Public hospital adherence was better in 3 domains and components (Management of Treatment Toxicity 95% vs 73%, Referrals 76% vs 15%, and Documentation of Key Clinical Factors 72% vs 64%, P < .05 for all), but it was lower in others (Testing 82% vs 96%, Adjuvant Therapy 76% vs 83%, Surgery 72% vs 86%, Surveillance 63% vs 94%, and Respect for Patient Preferences 52% vs 72%, P < .001 for all).CONCLUSIONS:The results showed that it is possible to deliver breast cancer care to vulnerable patients comparable in quality to the care received by the broader population. Further study should identify the factors that lead to variation in adherence across domains of quality. Cancer 2011. © 2011 American Cancer Society.