bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacology and placental transfer of a human αv integrin monoclonal antibody in rabbits
Authors: Martin Pauline L. , Zhou Zhao , Van den Bulck Kathleen , Kwok Deborah , Powers Gordon , Jiao Qun , Schantz Allen , Treacy George 
Published: February 2010

AbstractBACKGROUND: Intetumumab is a human IgG1 anti‐αv‐integrin monoclonal antibody that inhibits angiogenesis. Integrin binding and angiogenesis are important in reproduction including fertilization, implantation, and embryofetal development. These studies were designed to determine the pharmacological relevance of the rabbit for the evaluation of potential effects on embryofetal development and to evaluate the placental transfer of intetumumab in rabbits. METHODS: In vitro pharmacology studies evaluated the binding of intetumumab to rabbit cells and the inhibition of vessel sprouting from rabbit aorta. For the evaluation of placental transfer, pregnant rabbits (8/group) were injected intravenously with intetumumab 50 or 100 mg/kg every 2 days from Gestation Day (GD)7 to GD19. Maternal sera, fetal homogenates/sera, and amniotic fluid were collected at necropsy on GD19 or GD28 for evaluation of intetumumab concentrations. Clinical condition of the dams was monitored and fetuses were screened for abnormalities. RESULTS: Intetumumab (5–40 µg/mL) inhibited aortic cell adhesion to vitronectin and vessel sprouting from rabbit aortic rings. Immunohistochemical staining of rabbit tissues demonstrated binding of intetumumab to placenta. Administration of intetumumab to pregnant rabbits was well tolerated by the dams and the fetuses did not show major abnormalities. Fetal exposure to intetumumab relative to maternal exposure was <0.1% on GD19 and 100–130% on GD29. CONCLUSIONS: The rabbit is a pharmacologically relevant species for evaluation of potential developmental effects of intetumumab. Intetumumab crosses the rabbit placenta during the fetal period (GD 19–28). Birth Defects Res (Part B) 89:116–123, 2010. © 2010 Wiley‐Liss, Inc.
An antibody‐based affinity chromatography tool to assess Cu, Zn superoxide dismutase (SOD) G93A structural complexity in vivo
Authors: Palacios Florencia , Cota Germán , Horjales Sofía , Lima Analía , Battistoni Julio , Sotelo‐Silveira José , Marín Mónica 
Published: February 2010

Abstract‘Conformational diseases’ are a group of diverse disorders that have been associated with misfolding of specific proteins, leading to their aggregation in particular cell tissues. Despite their relevance, the mechanisms involved in neurodegenerative processes remains poorly understood. Mutations in Cu,Zn superoxide dismutase (SOD1) are implicated in death of motor neurons in amyotrophic lateral sclerosis. Among others, the SOD1G93A mutation is known to weaken the structure and this could lead to conformational variations of the protein. As an approach to understand the tissue‐specific propensity of protein aggregation, we developed an experimental procedure allowing rapid extraction of variants of human SOD1 (hSOD1) produced in different tissues. Using an antibody‐based affinity chromatography procedure enzymatically active hSOD was extracted, indicating preservation of its native conformation. Analysis of the eluted fractions of hSOD extracted from the brain and liver of transgenic hSODG93A rats provided evidence about heterodimers rSOD–hSODG93A formation in both extracts. Moreover, when characterized by 2‐DE and MALDI‐TOF/TOF MS, the extracted hSODG93A showed a complex profile suggesting the existence of various covalent modifications of the enzyme in both tissues. Thus, this method should allow following post‐translational modifications of hSOD1 produced in various tissues.
Die Evolution der Religiosität. Hat Gott Naturgeschichte?
Authors: Voland Eckart 
Published: February 2010

AbstractIn diesem Essay werden Befunde und Argumente zusammengetragen, die für die Auffassung sprechen, dass es sich bei der menschlichen Religiosität um ein Bündel evolutionärer Angepasstheiten handeln könnte. Wenngleich Religionen aus wissenschaftlicher Sicht keinen Wahrheitsanspruch erheben können, scheint religiöse Lebenspraxis mit adaptiven Vorteilen verbunden zu sein. Hierzu zählen vor allem eine verbesserte Kontingenzbewältigung, sowie die Stärkung von Kooperation und moralischer Solidarität nach innen durch Überwindung des so genannten “Schwarzfahrer‐Problems” bei gleichzeitiger Stärkung der Konkurrenzfähigkeit nach außen. In dieses Bild passt, dass die kognitiven Strategien des Menschen geradezu dafür prädisponiert sind, religiöse Überzeugungen zu generieren.
Peptide vor RNA? Das Wattenmeer als Wiege des Lebens
Authors: Egel Richard 
Published: February 2010

AbstractZur hypothetischen “RNA‐Welt” gibt es eine realistische Alternative, indem Peptide von stochastischen Sequenzen in ein autokatalytisches System von Quasiproteinen gelangten. Einige dieser Komponenten synthetisierten metabolische Coenzyme, unter denen geeignete Ribonukleotide zur Effektivisierung der Proteinsynthese herangezogen wurden. Hieraus gingen dann Ribosomen und andere RNA‐Moleküle hervor. Die thermodynamischen Voraussetzungen wurden am besten im Gezeitenwechsel der Meeresküste gewährleistet.
Hahn oder Henne?
Authors: Kronberg Inge 
Published: February 2010

AbstractOb Huhn, Fliege oder Maus: Die meisten Tiere begegnen uns als Männchen oder Weibchen – also in Form von zwei Geschlechtern. Dieses Erfolgsmodell der Evolution wurde unabhängig voneinander in vielfältiger Weise verwirklicht: Anders als bei Säugetieren, bei denen das Männchen das heterogametische Geschlecht (XY) darstellt, ist es bei Vögeln das Weibchen (ZW). Schon im unbefruchteten Ei steht also fest, ob einmal Hahn oder Henne schlüpfen wird. Welche Gene auf Z und W dabei eine Rolle spielen, wird aber erst allmählich verstanden.
Hermann Friedrich Stannius: Stannius'sche Körperchen und Stanniocalcin
Authors: Kinzelbach Ragnar 
Published: February 2010

AbstractManche ungemein kreative Wissenschaftler geraten in Vergessenheit, weil ihre Leistungen von Amtsnachfolgern oder Biografen nur sektoral wahrgenommen werden und daher der Zugang zur Gesamtleistung fehlt. So sitzt der Rostocker Professor H. F. Stannius, dort tätig von 1837 bis 1862, zwischen vielen Stühlen: Ein tüchtiger Entomologe, Arzt und Humanphysiologe, Humananatom, nebenbei Rektor und vielfacher Dekan, Erfinder und Beförderer der “Zootomie”, d. h. der vergleichenden Anatomie der Tiere, welche eine der Grundlagen für Darwins Evolutionstheorie war.
Screening of Biological Activities of a Series of Chalcone Derivatives against Human Pathogenic Microorganisms
Authors: Karaman İsa , Gezegen Hayreddin , Gürdere M. Burcu , Dingil Alparslan , Ceylan Mustafa 
Published: February 2010

AbstractIn an effort to develop new antimicrobial agents, a series of chalcone derivatives, 3–60, were prepared by Claisen–Schmidt condensation of appropriate acetophenones and 2‐furyl methyl ketones with appropriate aromatic aldehydes, furfural, and thiophene‐2‐carbaldehyde in an aqueous solution of NaOH and EtOH at room temperature. The synthesized compounds were characterized by means of their IR‐ and NMR‐spectral data, and elemental analysis. All compounds were tested for their antibacterial and antifungal activities by the disc diffusion method. For the most active compounds, also minimum inhibitory concentrations (MICs) were determined.
Habitat‐Dependent Variations in Berberine Content of Berberis asiaticaRoxb. ex. DC. in Kumaon, Western Himalaya
Authors: Andola Harish Chandra , Gaira Kailash Singh , Rawal Ranbeer Singh , Rawat Mohan Singh Muniyari , Bhatt Indra Dutt 
Published: February 2010

AbstractThe variation of the berberine content in roots and stem bark of Berberis asiatica with altitude and edaphic conditions in the western Himalaya was estimated by HPLC. The comparative assessment revealed a significantly higher berberine content in roots than in stem barks. Moreover, the berberine content varied significantly with altitude and edaphic conditions both in root and stem bark samples. The populations growing at low altitude contained significantly more berberine than the ones growing at high altitude. Also the moisture and potassium (K) percentage of the soil significantly influenced the berberine content.
Synthesis and Biophysical Properties of Oligodeoxynucleotides Containing 2′‐Deoxy‐5‐(4‐nitro‐1H‐imidazol‐1‐yl)‐β‐D‐uridine and 2′‐Deoxy‐5‐(1,3‐dioxo‐1H‐benzo[de]isoquinolin‐2(3H)‐yl)‐β‐D‐uridine Monomers
Authors: Gondela Andrzej , Kumar Thatikonda Santhosh , Walczak Krzysztof , Wengel Jesper 
Published: February 2010

AbstractDetection of single‐nucleotide polymorphisms (SNPs) of biologically relevant DNA and RNA samples remain a scientific and practical challenge. We have synthesized phosphoramidite building blocks and oligodeoxynucleotide probes containing novel 2′‐deoxyuridine monomers modified by 5‐(4‐nitro‐1H‐imidazol‐1‐yl; (monomer X) or 2′‐deoxy‐5‐(1,3‐dioxo‐1H‐benzo[de]isoquinolin‐2(3H)‐yl; monomer Y) substituents. The effects of monomers X and Y on duplex thermal stability, and their capability towards discrimination of single‐base mismatches were furthermore studied. Encouraging results were obtained with respect to thermal mismatch discrimination using oligodeoxynucleotides containing monomer X and fluorescence‐based discrimination using oligodeoxynucleotides containing monomer Y.
Triplex‐Stabilizing Properties of Parallel Clamps Carrying LNA Derivatives at the Hoogsteen Strand
Authors: Alvira Margarita , Eritja Ramon 
Published: February 2010

AbstractDNA Parallel clamps with a polypurine strand linked to a polypyrimidine Hoogsteen strand containing locked nucleic acids bind their corresponding polypyrimidine targets with high affinity.
The Resurgence of Acyclic Nucleic Acids
Authors: Zhang Su , Switzer Christopher , Chaput John C. 
Published: February 2010

AbstractThis review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic‐acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self‐assembly.
Control of Biocatalytic Transformations by Programmed DNA Assemblies
Authors: Freeman Ronit , Sharon Etery , Teller Carsten , Willner Itamar 
Published: February 2010

AbstractThis study demonstrates the self‐assembly of inhibitor/enzyme‐tethered nucleic acid fragments or enzyme I‐, enzyme II‐modified nucleic acids into functional nanostructures that lead to the controlled inhibition of the enzyme or the activation of an enzyme cascade. In one system, the anti‐cocaine aptamer subunits are modified with monocarboxy methylene blue (MB+) as the inhibitor and with choline oxidase (ChOx). The cocaine‐induced self‐assembly of the aptamer subunits complex results in the inhibition of ChOx by MB+. In a further configuration, two nucleic acids of limited complementarity are functionalized at their 3′ and 5′ ends with glucose oxidase (GOx) and horseradish peroxidase (HRP), respectively, or with MB+and ChOx. In the presence of a target DNA sequence, synergistic complementary base‐pairing occurs, thus leading to stable supramolecular Y‐shaped nanostructures of the nucleic acid units. A GOx/HRP bienzyme cascade or the programmed inhibition of ChOx by MB+is demonstrated in the resulting nucleic acid nanostructures. A quantitative theoretical model that describes the nucleic acid assemblies and that results in the inhibition of ChOx by MB+or in the activation of the GOx/HRP cascade, respectively, is provided.
ChemInform Abstract: Half Antiperovskites. Part 4. Crystallographic and Electronic Structure Investigation on A2Rh3S2 (A: In, Sn, Tl, Pb, Bi).
Authors: Anusca Irina , Schmid Andreas , Peter Philipp , Rothballer Jan , Pielnhofer Florian , Weihrich Richard 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Crystal Structures of the Cyanidofluoroborates K[BFx(CN)4‐x], x = 0—4.
Authors: Bernhardt Eduard , Willner Helge 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electronic Structure and Photoluminescence Properties of Eu2+‐Activated Ca2BN2F.
Authors: Li Y. Q. , Fang C. M. , Fang Y. , Delsing A. C. A. , de With G. , Hintzen H. T. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Crystal Structures and Magnetic Properties of Two‐Dimensional Antiferromagnets Co1‐xZnxTeMoO6.
Authors: Doi Yoshihiro , Suzuki Ryo , Hinatsu Yukio , Ohoyama Kenji 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Synthesis of Carbon‐Decorated Single‐Crystalline Fe3O4 Nanowires and Their Application as High Performance Anode in Lithium Ion Batteries.
Authors: Muraliganth Theivanayagam , Murugan Arumugam Vadivel , Manthiram Arumugam 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: K2Ca6Si4O15 — Structural and Spectroscopical Studies on a Mixed Tetrahedral—Octahedral Framework.
Authors: Arroyabe E. , Kaindl R. , Toebbens D. M. , Kahlenberg V. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Thallium Iodates — Synthesis, Characterization, and Calculations of Tl(IO3)3 and Tl4(IO3)6, [Tl3+Tl3+(IO3)6].
Authors: Yeon Jeongho , Kim Sang‐Hwan , Halasyamani P. Shiv 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dinuclear Manganese and Cobalt Complexes with Cyclic Polyoxovanadate Ligands: Synthesis and Characterization of [Mn2V10O30]6‐ and [Co2(H2O)2V10O30] 6‐.
Authors: Inami Shinnosuke , Nishio Masaki , Hayashi Yoshihito , Isobe Kiyoshi , Kameda Hiroyuki , Shimoda Tatsuya 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Low Temperature Molten‐Salt Synthesis of Nanocrystalline Cubic Sr2SbMnO6.
Authors: Baral Antara , Varma K. B. R. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation and Properties of Antiperovskite‐Type Nitrides: InNNi3 and InNCo3.
Authors: Cao W. H. , He B. , Liao C. Z. , Yang L. H. , Zeng L. M. , Dong C. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dual‐Activation Asymmetric Strecker Reaction of Aldimines and Ketimines Catalyzed by a Tethered Bis(8‐quinolinolato) Aluminum Complex.
Authors: Abell Joshua P. , Yamamoto Hisashi 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Useful Synthetic Equivalent of an Acetone Enolate.
Authors: Maslak Veselin , Tokic‐Vujosevic Zorana , Ferjancic Zorana , Saicic Radomir N. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Taming the Silylium Ion for Low‐Temperature Diels—Alder Reactions.
Authors: Klare Hendrik F. T. , Bergander Klaus , Oestreich Martin 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Michael Addition Initiated Carbocyclization Sequences with Nitroolefins for the Stereoselective Synthesis of Functionalized Heterocyclic and Carbocyclic Systems.
Authors: Dumez Estelle , Durand Anne‐Catherine , Guillaume Martial , Roger Pierre‐Yves , Faure Robert , Pons Jean‐Marc , Herbette Gaetan , Dulcere Jean‐Pierre , Bonne Damien , Rodriguez Jean 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Erbium(III) Triflate Is a Highly Efficient Catalyst for the Synthesis of β‐Alkoxy Alcohols, 1,2‐Diols and β‐Hydroxy Sulfides by Ring Opening of Epoxides.
Authors: Dalpozzo Renato , Nardi Monica , Oliverio Manuela , Paonessa Rosina , Procopio Antonio 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reusable Copper‐Aluminum Hydrotalcite/rac‐BINOL System for Room Temperature Selective Aerobic Oxidation of Alcohols.
Authors: Kantam M. Lakshmi , Arundhathi R. , Likhar Pravin R. , Damodara D. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Zn‐Mediated, Pd‐Catalyzed Cross‐Couplings in Water at Room Temperature Without Prior Formation of Organozinc Reagents.
Authors: Krasovskiy Arkady , Duplais Christophe , Lipshutz Bruce H. 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient Chemo‐ and Regioselective Silylation of ‐OH Groups and Cyanosilylation of Aldehydes Promoted by TiCl2(OTf)—SiO2 as a New Recyclable Catalyst.
Authors: Firouzabadi Habib , Iranpoor Nasser , Farahi Soghra 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Catalyzed Negishi Coupling Toward an Effective Olefin Synthesis.
Authors: Hatakeyama Takuji , Nakagawa Naohisa , Nakamura Masaharu 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three‐Component Synthesis of α‐Branched Amines under Barbier‐Like Conditions.
Authors: Le Gall Erwan , Haurena Caroline , Sengmany Stephane , Martens Thierry , Troupel Michel 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quinoxaline‐Based U‐Shaped Septuple‐Bridged [7,7]Orthocyclophanes: Synthesis, Solid‐State Structure, and Self‐Assembly.
Authors: Chou Teh‐Chang , Lin Kuen‐Cheng , Wu Cheng‐An 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Ring‐Opening Reactions of Racemic Ethynyl Epoxides via Copper—Allenylidene Intermediates: Efficient Approach to Chiral β‐Amino Alcohols.
Authors: Hattori Gaku , Yoshida Akiko , Miyake Yoshihiro , Nishibayashi Yoshiaki 
Published: February 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.