bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Lanthanide Amidinates and Guanidinates: From Laboratory Curiosities to Efficient Homogeneous Catalysts and Precursors for Rare‐Earth Oxide Thin Films
Authors: Edelmann Frank T. 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Impact of Natural Products on Developing New Anticancer Agents
Authors: Cragg Gordon M. , Grothaus Paul G. , Newman David J. 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Regulation of Tumor Angiogenesis and Perfusion via Redox Signaling
Authors: Miller Thomas W. , Isenberg Jeff S. , Roberts David D. 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dissecting Molecular Mechanisms in the Living Brain of Dementia Patients
Authors: Barrio Jorge R. , Satyamurthy Nagichettiar , Huang Sung‐Cheng , Petric Andrej , Small Cary W. , Kepe Vladimir 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nanoparticulate Assemblies of Amphiphiles and Diagnostically Active Materials for Multimodality Imaging
Authors: Mulder Willem J. M. , Strijkers Gustav J. , van Tilborg Geralda A. F. , Cormode David P. , Fayad Zahi A. , Nicolay Klaas 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Therapeutic Strategy for Autoimmune and Chronic Inflammatory Disease Based on Clinical Results Using IL‐6 Blocking Therapy with a Humanized anti‐IL‐6 Receptor Antibody
Authors: Yoshizaki Kazuyuki 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: B Cell Targeting Therapy Using the anti‐CD20 Antibody in Autoimmune Diseases
Authors: Tanaka Yoshiya 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Lipid‐Shelled Vehicles: Engineering for Ultrasound Molecular Imaging and Drug Delivery
Authors: Ferrara Katherine W. , Borden Mark A. , Zhang Hua 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gd—Hydroxypyridinone (HOPO)‐Based High‐Relaxivity Magnetic Resonance Imaging (MRI) Contrast Agents
Authors: Datta Ankona , Raymond Kenneth N. 
Published: October 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Berechnung von Dampf/Flüssig‐Gleichgewichtsdaten binärer Gemische aus Dampfdruckdaten
Authors: Aust E. , Jacob K.‐H. , Knorr T. , Schindler M. 
Published: October 2009

AbstractVorgestellt wird ein Verfahren, das aus wenigen Dampfdruckkurven binärer Gemische bei verschiedenen Zusammensetzungen die Wechselwirkungsparameter für die Berechnung von Aktivitätskoeffizienten zugänglich macht und so die Vorhersage von Dampf/Flüssig‐Gleichgewichten ermöglicht. Der Vorteil dieses Verfahrens liegt in der experimentell einfachen Zugänglichkeit von Dampfdruckdaten. Eine Demonstration dieses Verfahrens erfolgt anhand zweier binärer Gemische, für die aus Dampfdruckdaten die entsprechenden Dampf/Flüssig‐Gleichgewichte vorhergesagt und mit experimentell ermittelten Daten verglichen werden.
Adsorptive Entfernung von Monophenolethern aus primären und sekundären Alkoholen mit Aktivkohlen
Authors: Bathen D. , Gräf T. , Pasel C. 
Published: October 2009

AbstractAufgrund der steigenden Nachfrage nach hochreinen Lösungsmitteln für spezielle Applikationen bei der Produktion von Elektronikkomponenten, Pharmazeutika oder diversen Life Science‐Produkten gewinnt die adsorptive Entfernung von Spurenkomponenten aus der flüssigen Phase zunehmend an Bedeutung. Im Rahmen dieses Beitrags werden die experimentellen Ergebnisse von 52 Adsorptionsisothermenmessungen vorgestellt. Es wurden Modellsysteme mit Aktivkohlen als Adsorbentien, Monophenolethern als Adsorptiven sowie primären und sekundären Alkoholen als Lösungsmitteln untersucht, um eine Lücke in der Stoffdatenliteratur zu schließen. Es konnte gezeigt werden, dass die Länge der aliphatischen C‐Atomkette der Alkohole einen bestimmenden Einfluss auf den Adsorptionsprozess ausübt. Die experimentellen Befunde können mit einem einfachen empirischen Modell gut beschrieben werden.
Prognostic value of quantitative p63 immunostaining in adenoid cystic carcinoma of salivary gland assessed by computerized image analysis
Authors: Ramer Naomi , Wu HaiShan , Sabo Edmond , Ramer Yael , Emanuel Patrick , Orta Lurmag , Burstein David E. 
Published: October 2009

AbstractBACKGROUND:In a long‐term retrospective immunohistochemical study of adenoid cystic carcinoma (ACC) of salivary gland, we investigated the relation of p63 immunodetection to prognosis. Although it is generally agreed that the solid pattern is the most aggressive pattern of growth, ACCs with predominantly cribriform or tubular patterns have an unpredictable clinical course, with a relatively favorable 5‐year survival but a low 20‐year survival.METHODS:Formalin‐fixed paraffin sections from 35 cases of ACC showing a predominantly better differentiated histopathology, ie, cribriform or tubular patterns of growth, were immunostained for p63. Automated image analysis was used to quantify p63 positivity, using a modification of a previously developed algorithm.RESULTS:Patients alive for more than 10 years had a lower extent of p63 expression than those who died of disease. Kaplan‐Meier analysis revealed that separation of patients with morbidity and mortality from those alive with no evidence of disease, could be achieved at a cutoff of 35% p63 positivity (P = .0031, log‐rank test). Multivariate analysis using the Cox proportional hazard model revealed p63 and tumor stage to be independent predictors of survival (P = .012 and P = .0003, respectively).CONCLUSIONS:To our knowledge, the present study is the first to report prognostic significance of p63 in salivary gland ACC and the first report of a robust and well‐studied immunohistochemical stain performable on routinely fixed and processed tissue with prognostic utility. Cancer 2010. © 2010 American Cancer Society.
Primary plasma cell leukemia
Authors: Ramsingh Giridharan , Mehan Paul , Luo Jingqin , Vij Ravi , Morgensztern Daniel 
Published: October 2009

AbstractBACKGROUND:Primary plasma cell leukemia (PCL) is a rare plasma cell disorder, and current knowledge regarding survival in this disease is limited to small series of patients. Although there has been significant improvement in the survival of patients with multiple myeloma (MM) over the past few decades, it is not known whether there has been a similar trend for PCL.METHODS:The authors analyzed the Surveillance, Epidemiology, and End Results (SEER) database to evaluate the characteristics and survival of patients who had PCL compared with those of patients who had MM.RESULTS:Among 291 patients with PCL, the median age was 67 years (range, 19‐98 years), the distribution of men and women was nearly equal, and the majority of patients were white (79.4%). The median overall survival (OS) was 4 months and the median disease‐specific survival (DSS) was 6 months for patients with PCL; the 1‐year, 2‐year, and 5‐year OS rates were 27.8%, 14.1%, and 6.4%, respectively. There were no survival differences noted according to sex or race. Patients aged <60 years were found to have a better median OS compared with patients aged ≥60 years (median OS, 7 months vs 3 months; P = .007), although the 5‐year OS was equally poor in both groups (6.3% vs 6.4%, respectively). During the same period, 49,106 patients with MM were identified. Unlike MM, in which there has been a modest but statistically significant improvement in OS and DSS noted over time, no significant improvement was evident for PCL.CONCLUSIONS:The poor long‐term outcome and the lack of survival improvement in PCL suggest the need for better therapeutic options for these patients. Cancer 2009. © 2009 American Cancer Society.
Comparative anatomy of the locus coeruleus in humans and nonhuman primates
Authors: Sharma Yukti , Xu Tao , Graf Werner M. , Fobbs Archie , Sherwood Chet C. , Hof Patrick R. , Allman John M. , Manaye Kebreten F. 
Published: October 2009

AbstractThe locus coeruleus (LC) is a dense cluster of neurons that projects axons throughout the neuroaxis and is located in the rostral pontine tegmentum extending from the level of the inferior colliculus to the motor nucleus of the trigeminal nerve. LC neurons are lost in the course of several neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. In this study we used Nissl staining and tyrosine hydroxylase (TH) immunoreactivity to compare the human LC with that of closely related primate species, including great and lesser apes, and macaque monkeys. TH catalyzes the initial and rate‐limiting step in catecholamine biosynthesis. The number of TH‐immunoreactive (TH‐ir) neurons was estimated in each species using stereologic methods. In the LC of humans the mean total number of TH‐ir neurons was significantly higher compared to the other primates. Because the total number of TH‐ir neurons in the LC was highly correlated with the species mean volume of the medulla oblongata, cerebellum, and neocortical gray matter, we conclude that much of the observed phylogenetic variation can be explained by anatomical scaling. Notably, the total number of LC neurons in humans was most closely predicted by the nonhuman allometric scaling relationship relative to medulla size, whereas the number of LC neurons in humans was considerably lower than predicted according to neocortex and cerebellum volume. J. Comp. Neurol. 518:963–971, 2010. © 2009 Wiley‐Liss, Inc.
Expression of calcium‐binding proteins and nNOS in the human vestibular and precerebellar brainstem
Authors: Baizer Joan S. , Broussard Dianne M. 
Published: October 2009

AbstractInformation about the position and movement of the head in space is coded by vestibular receptors and relayed to four nuclei that comprise the vestibular nuclear complex (VNC). Many additional brainstem nuclei are involved in the processing of vestibular information, receiving signals either directly from the eighth nerve or indirectly via projections from the VNC. In cats, squirrel monkeys, and macaque monkeys, we found neurochemically defined subdivisions within the medial vestibular nucleus (MVe) and within the functionally related nucleus prepositus hypoglossi (PrH). In humans, different studies disagree about the borders, sizes, and possible subdivisions of the vestibular brainstem. In an attempt to clarify this organization, we have begun an analysis of the neurochemical characteristics of the human using brains from the Witelson Normal Brain Collection and standard techniques for antigen retrieval and immunohistochemistry. Using antibodies to calbindin, calretinin, parvalbumin, and nitric oxide synthase, we find neurochemically defined subdivisions within the MVe similar to the subdivisions described in cats and monkeys. The neurochemical organization of PrH is different. We also find unique neurochemical profiles for several structures that suggest reclassification of nuclei. These data suggest both quantitative and qualitative differences among cats, monkeys, and humans in the organization of the vestibular brainstem. These results have important implications for the analysis of changes in that organization subsequent to aging, disease, or loss of input. J. Comp. Neurol. 518:872–895, 2010. © 2009 Wiley‐Liss, Inc.
Nonlinear Hamiltonian waves with constant frequency and surface waves on vorticity discontinuities
Authors: Biello Joseph , Hunter John K. 
Published: October 2009

AbstractWaves with constant, nonzero linearized frequency form an interesting class of nondispersive waves whose properties differ from those of nondispersive hyperbolic waves. We propose an inviscid Burgers‐Hilbert equation as a model equation for such waves and give a dimensional argument to show that it models Hamiltonian surface waves with constant frequency. Using the method of multiple scales, we derive a cubically nonlinear, quasi‐linear, nonlocal asymptotic equation for weakly nonlinear solutions. We show that the same asymptotic equation describes surface waves on a planar discontinuity in vorticity in two‐dimensional inviscid, incompressible fluid flows. Thus, the Burgers‐Hilbert equation provides an effective equation for these waves. We describe the Hamiltonian structure of the Burgers‐Hilbert and asymptotic equations, and show that the asymptotic equation can also be derived by means of a near‐identity transformation. We derive a semiclassical approximation of the asymptotic equation and show that spatially periodic, harmonic traveling waves are linearly and modulationally stable. Numerical solutions of the Burgers‐Hilbert and asymptotic equations are in excellent agreement in the appropriate regime. In particular, the lifespan of small‐amplitude smooth solutions of the Burgers‐Hilbert equation is given by the cubically nonlinear timescale predicted by the asymptotic equation. © 2009 Wiley Periodicals, Inc.
Java implementation platform for the integrated state‐ and event‐based specification in PROB
Authors: Yang L. , Poppleton M. R. 
Published: October 2009

AbstractPROB is an animation and model checking tool, which supports integrated event‐ and state‐based specifications combining B and CSP. We present an initial strategy for implementing the combined specification model as a concurrent Java program. Our Java implementation for the combined B and CSP model uses a similar approach to that of JCSP. The restricted operational semantics for the integrated B and CSP model in PROB is defined. Then a new Java package, JCSProB, is developed for implementing the semantics. The new package supports external choice with multi‐way synchronization, and introduces an improved multi‐threading implementation from JCSP. Copyright © 2009 John Wiley & Sons, Ltd.
The Quakesim portal and services: new approaches to science gateway development techniques
Authors: Pierce Marlon E. , Gao Xiaoming , Pallickara Sangmi L. , Guo Zhenhua , Fox Geoffrey C. 
Published: October 2009

AbstractTraditional techniques in building science portals and gateways are being challenged by new techniques such as Web 2.0 and Cloud Computing. This paper discusses some of our efforts to evaluate these techniques as we evolve the QuakeSim architecture. We believe that architecturally both traditional and newer approaches for Gateways are very similar; thus, giving us a path for moving to hybrid approaches. In this paper, we specifically evaluate techniques for building interactive user interfaces that rely on remote services; architectural approaches for managing massive job submissions that can include both parallel and serial jobs; and an architectural prototype for building component‐based containers compatible with emerging standards. Copyright © 2009 John Wiley & Sons, Ltd.
Highly Dispersed Pd Species Active in the Suzuki–Miyaura Reaction
Authors: Okumura Kazu , Matsui Hirosuke , Tomiyama Takuya , Sanada Takashi , Honma Tetsuo , Hirayama Sayaka , Niwa Miki 
Published: October 2009

AbstractStructures of Pd/zeolites immersed in solvents were measured by in situ X‐ray absorption fine structure (XAFS). Systematic studies revealed that the selection of an appropriate support (USY‐zeolite), thermal treatment temperature of USY, solvent (o‐xylene), H2 partial pressure (6 %), and the use of a Pd amine complex affect the structure of Pd. As a result, we found that monomeric Pd can be obtained in the USY support with H2 bubbling in o‐xylene. The structural properties of Pd correlate well with its catalytic performance in the Suzuki–Miyaura coupling reactions; a very high TON of up to 11 000 000 was obtained over the monomeric Pd.
Update on the Development of a New U.S. Kidney Transplant Allocation System
Authors: Norman Silas P. 
Published: October 2009

AbstractA substantial revision of the adult kidney allocation system in the U.S. is currently underway. The proposed revised system combines the new concepts of life years from transplant (LYFT), the donor profile index (DPI), and dialysis time (DT) into an overall kidney allocation score (KAS). The KAS for the first time integrates a measure of medical utility into kidney allocation. A KAS‐based system holds the promise of improved efficiency, increased waitlist access and a gain in the number of life‐years achieved from transplantation. This article discusses the rationale for the development of a new system, the state of the KAS proposal, and the challenges that remain to implementation of a new kidney allocation system.
Development of behavior in the litter huddle in rat pups: Within‐ and between‐litter differences
Authors: Bautista Amando , García‐Torres Esmeralda , Prager Geraldine , Hudson Robyn , Rödel Heiko G. 
Published: October 2009

AbstractEarly postnatal growth in mammals can be considerably influenced by litter size and often differs among littermates in relation to birth mass. In a study of Long Evans laboratory rats we asked whether within‐ and between‐litter differences in body mass and growth are related to behavioral development during early postnatal life. For this, we analyzed the amount of general motor activity and the display of directed, seemingly goal‐oriented interactions within the litter huddle in previsual pups. During the study period from postnatal days 2 to 11, we found significant changes in pup behavior, showing a nonlinear, quadratic shape. General motor activity and, more specifically, the display of behaviors apparently directed to reaching central positions in the litter huddle increased during the first postnatal days and then decreased again. However, pups from small litters that grow more rapidly than pups from large litters, showed a faster increase in both behaviors, whereas the young from large litters reached a higher maximum. We also found striking within‐litter differences in the amount of directed behavior performed by light and heavy pups, with higher levels in the former group, most probably because light pups that have a less favorable body mass‐to‐volume ratio and more often occupy peripheral positions in the litter huddle, make a greater effort to reach thermally favorable central positions. In conclusion, our study shows there to be consistent between‐litter as well as within‐litter differences in behavioral patterns during early life. These differences might have important implications for an individual's long‐term behavioral and physiological performance. © 2009 Wiley Periodicals, Inc. Dev Psychobiol 52: 35–43, 2010
The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β‐cell function in middle‐aged male subjects
Authors: Hwang You‐Cheol , Jeong In‐Kyung , Ahn Kyu Jeung , Chung Ho Yeon 
Published: October 2009

AbstractBackgroundRecent human studies support the notion that serum osteocalcin increases β‐cell proliferation and insulin secretion, and improves insulin sensitivity. However, no study has examined the effects of serum osteocalcin γ‐carboxylation status on these associations or determined the role of uncarboxylated osteocalcin in glucose metabolism in humans.MethodsThe aim of this study was to determine the association between uncarboxylated osteocalcin and β‐cell function and insulin sensitivity in humans. As many as 199 men, aged 25–60 years (mean age, 47 years), who had never been treated with glucose lowering agents, were enrolled in this cross‐sectional study. OGTT was performed and other metabolic parameters, such as, BMI, BP, lipid profiles, and both uncarboxylated and carboxylated osteocalcin plasma levels were measured.ResultsWhen subjects were divided into tertiles by uncarboxylated and carboxylated osteocalcin plasma concentrations, subjects in the upper tertile of each showed lower fasting and post‐challenge glucose levels after adjusting for age and BMI (P < 0.05). The upper uncarboxylated osteocalcin tertile was associated with higher HOMA‐B% levels, which are representative of β‐cell function (P < 0.05), and the upper carboxylated osteocalcin tertile was associated with lower HOMA‐IR values, which are representative of insulin resistance (P < 0.05).ConclusionsElevated levels of both carboxylated and uncarboxylated forms of osteocalcin were associated with improved glucose tolerance. Moreover, the uncarboxylated form of osteocalcin was found to be associated with enhanced β‐cell function, and the carboxylated form was associated with improved insulin sensitivity in middle‐aged male subjects. Copyright © 2009 John Wiley & Sons, Ltd.
Characterization of the expression pattern of the PRC2 core subunit Suz12 during embryonic development of Xenopus laevis
Authors: Aldiri Issam , Vetter Monica L. 
Published: October 2009

AbstractThe Polycomb repressive complex 2 is a multimeric aggregate that mediates silencing of a broad range of genes, and is associated with important biological contexts such as stem cell maintenance and cancer progression. PRC2 mainly trimethylates lysine 27 of histone H3 and is composed of three essential core subunits: EZH2, EED, and SUZ12. The Xenopus orthologs of PRC2 subunits Ezh2 and Eed have been described but Suz12 remained unidentified. Here, we report the cloning of the Xenopus Suz12, and determine its spatiotemporal expression during development. Xsuz12 transcript is provided maternally and continues to be expressed throughout development, particularly in the anterior part of the developing central nervous system. Importantly, comparative analysis of the expression of the PRC2 subunits Xez, Xeed, and Xrbbp4 indicates that their expression largely coincides with Xsuz12 in the nervous system, suggesting that PRC2 may have unexplored functions in the development of the frog central nervous system. Developmental Dynamics 238:3185–3192, 2009. © 2009 Wiley‐Liss, Inc.