bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential expression of protease‐activated receptors in monocytes from patients with primary antiphospholipid syndrome
Authors: López‐Pedrera Chary , Aguirre Maria Ángeles , Buendía Paula , Barbarroja Nuria , Ruiz‐Limón Patricia , Collantes‐Estevez Eduardo , Velasco Francisco , Khamashta Munther , Cuadrado Maria José 
Published: January 2010

AbstractObjectiveTo investigate the expression of protease‐activated receptors (PARs), their potential regulation by anticardiolipin antibodies (aCL), and their association with the expression of other molecules relevant to thrombosis in monocytes obtained from 62 patients with primary antiphospholipid syndrome (APS).MethodsMonocytes were isolated from peripheral blood mononuclear cells by magnetic depletion of nonmonocytes. Expression of tissue factor (TF) and PARs 1–4 genes was measured by quantitative real‐time reverse transcription–polymerase chain reaction. Cell surface TF and PARs 1–4 expression was analyzed by flow cytometry. For in vitro studies, purified normal monocytes were incubated with purified APS patient IgG, normal human serum IgG, or lipopolysaccharide, in the presence or absence of specific monoclonal antibodies anti–PAR‐1 (ATAP2) or anti–PAR‐2 (SAM11) to test the effect of blocking the active site of PAR‐1 or PAR‐2.ResultsAnalysis of both mRNA and protein for the 4 PARs revealed significantly increased expression of PAR‐2 as compared with the control groups. PAR‐1 was significantly overexpressed in APS patients with thrombosis and in the control patients with thrombosis but without APS. PAR‐3 expression was not significantly altered. PAR‐4 expression was absent in all groups analyzed. In addition, we demonstrated a correlation between the levels of PAR‐2 and the titers of IgG aCL, as well as parallel behavior of TF and PAR‐2 expression. In vitro, IgG from APS patients significantly increased monocyte expression of PAR‐1 and PAR‐2. Inhibition studies suggested that there was direct cross‐talk between TF and PAR‐2, such that inhibition of PAR‐2 prevented the aCL‐induced expression of TF.ConclusionThese results provide the first demonstration of increased expression of PARs in monocytes from patients with APS. Thus, PAR antagonists might have therapeutic potential as antithrombotic agents in APS.
Antimalarial treatment may have a time‐dependent effect on lupus survival: Data from a multinational Latin American inception cohort
Authors: Shinjo Samuel K. , Bonfá Eloísa , Wojdyla Daniel , Borba Eduardo F. , Ramirez Luis A. , Scherbarth Hugo R. , Brenol João C. Tavares , Chacón‐Diaz Rosa , Neira Oscar J. , Berbotto Guillermo A. , de la Torre Ignacio Garcia , Acevedo‐Vázquez Eduardo M. , Massardo Loreto , Barile‐Fabris Leonor A. , Caeiro Francisco , Silveira Luis H. , Sato Emilia I. , Buliubasich Sandra , Alarcón Graciela S. , Pons‐Estel Bernardo A. 
Published: January 2010

AbstractObjectiveTo evaluate the beneficial effect of antimalarial treatment on lupus survival in a large, multiethnic, international longitudinal inception cohort.MethodsSocioeconomic and demographic characteristics, clinical manifestations, classification criteria, laboratory findings, and treatment variables were examined in patients with systemic lupus erythematosus (SLE) from the Grupo Latino Americano de Estudio del Lupus Eritematoso (GLADEL) cohort. The diagnosis of SLE, according to the American College of Rheumatology criteria, was assessed within 2 years of cohort entry. Cause of death was classified as active disease, infection, cardiovascular complications, thrombosis, malignancy, or other cause. Patients were subdivided by antimalarial use, grouped according to those who had received antimalarial drugs for at least 6 consecutive months (user) and those who had received antimalarial drugs for <6 consecutive months or who had never received antimalarial drugs (nonuser).ResultsOf the 1,480 patients included in the GLADEL cohort, 1,141 (77%) were considered antimalarial users, with a mean duration of drug exposure of 48.5 months (range 6–98 months). Death occurred in 89 patients (6.0%). A lower mortality rate was observed in antimalarial users compared with nonusers (4.4% versus 11.5%; P< 0.001). Seventy patients (6.1%) had received antimalarial drugs for 6–11 months, 146 (12.8%) for 1–2 years, and 925 (81.1%) for >2 years. Mortality rates among users by duration of antimalarial treatment (per 1,000 person‐months of followup) were 3.85 (95% confidence interval [95% CI] 1.41–8.37), 2.7 (95% CI 1.41–4.76), and 0.54 (95% CI 0.37–0.77), respectively, while for nonusers, the mortality rate was 3.07 (95% CI 2.18–4.20) (P for trend < 0.001). After adjustment for potential confounders in a Cox regression model, antimalarial use was associated with a 38% reduction in the mortality rate (hazard ratio 0.62, 95% CI 0.39–0.99).ConclusionAntimalarial drugs were shown to have a protective effect, possibly in a time‐dependent manner, on SLE survival. These results suggest that the use of antimalarial treatment should be recommended for patients with lupus.
Association of the FAM167A–BLK region with systemic sclerosis
Authors: Ito Ikue , Kawaguchi Yasushi , Kawasaki Aya , Hasegawa Minoru , Ohashi Jun , Kawamoto Manabu , Fujimoto Manabu , Takehara Kazuhiko , Sato Shinichi , Hara Masako , Tsuchiya Naoyuki 
Published: January 2010

AbstractObjectiveAn association of single‐nucleotide polymorphisms (SNPs) in the FAM167A (previously referred to as C8orf13)–BLK region with systemic lupus erythematosus (SLE) has been demonstrated in Caucasians and in Asians. Recent studies have shown that many genes, including IRF5, STAT4, and PTPN22, are shared susceptibility genes in multiple autoimmune diseases. We undertook the current study to examine whether the FAM167A–BLK region is also associated with susceptibility to systemic sclerosis (SSc).MethodsJapanese patients with SSc (n = 309) and healthy controls (n = 769) were enrolled in a 2‐tiered case–control association study. In tier 1, 124 patients and 412 controls were tested to determine association of 16 tag SNPs encompassing the FAM167A–BLK region with SSc. In tier 2, an additional 185 patients and 357 controls were analyzed for SNP rs13277113.ResultsTwo haplotype blocks that correspond approximately to FAM167A and BLK were observed. In tier 1 of the study, the rs13277113A allele in the BLK block exhibited the most significant association with SSc after correction for multiple testing (permutated P = 0.024). Two SNP haplotypes formed by rs13277113 and the most significant SNP in the FAM167A block did not exhibit stronger association. When samples from tier 1 and tier 2 were combined, the rs13277113A allele was significantly associated with SSc (odds ratio 1.45 [95% confidence interval 1.17–1.79], P = 6.1 × 10−4). Association or a tendency toward association of rs13277113A with SSc was observed regardless of a patient's autoantibody profile or whether a patient had diffuse cutaneous or limited cutaneous SSc.ConclusionOur findings indicate that the rs13277113A allele is associated not only with SLE but also with SSc and that the FAM167A–BLK region is a common genetic risk factor for both SLE and SSc.
Evaluating the effects of reactivity to supervisor presence on staff response to tactile prompts and self‐monitoring in a group home setting
Authors: Mowery Judy M. , Miltenberger Raymond G. , Weil Timothy M. 
Published: January 2010

AbstractBecause staff management research in group home settings typically involves direct observation of staff performance, reactivity to being observed is a potential limitation in these studies. The current study evaluated the use of a tactile prompt, self‐monitoring, and feedback to increase positive interaction in a group home setting. Reactivity was assessed by having a confederate observe staff positive interaction when the supervisor was present and when the supervisor was absent. The effect of supervisor presence was evaluated using an alternating treatment within a multiple baseline across participants' research design. Results showed that two of four participants increased positive interactions only when a supervisor was present and the two other participants increased positive interaction only when a supervisor was present and provided feedback. Copyright © 2010 John Wiley & Sons, Ltd.
The Role of Flexibility in the Rational Design of Modularly Assembled Ligands Targeting the RNAs that Cause the Myotonic Dystrophies
Authors: Disney Matthew D. , Lee Melissa M. , Pushechnikov Alexei , Childs‐Disney Jessica L. 
Published: January 2010

AbstractModularly assembled ligands were designed to target the RNAs that cause two currently untreatable neuromuscular disorders, myotonic dystrophy types 1 (DM1) and 2 (DM2). DM1 is caused by an expanded repeating sequence of CUG, and DM2 is caused by expanded CCUG repeats. Both are present in noncoding regions and fold into hairpins with either repeating 1×1 nucleotide UU (DM1) or 2×2 nucleotide 5′‐CU/3′‐UC (DM2) internal loops separated by two GC pairs. The repeats are toxic because they sequester the RNA splicing regulator muscleblind‐like 1 protein (MBNL1). Rational design of ligands targeting these RNAs was enabled by a database of RNA motif–ligand partners compiled by using two‐dimensional combinatorial screening (2DCS). One 2DCS study found that the 6′′‐azido‐kanamycin A module binds internal loops similar to those found in DM1 and DM2. In order to further enhance affinity and specificity, the ligand was assembled on a peptoid backbone to precisely control valency and the distance between ligand modules. Designed compounds are more potent and specific binders to the toxic RNAs than MBNL1 and inhibit the formation of the RNA–protein complexes with nanomolar IC50 values. This study shows that three important factors govern potent inhibition: 1) the surface area sequestered by the assembled ligands; 2) the spacing between ligand modules since a longer distance is required to target DM2 RNAs than DM1 RNAs; and 3) flexibility in the modular assembly scaffold used to display the RNA‐binding module. These results have impacts on the general design of assembled ligands targeting RNAs present in genomic sequence.
Copper‐Catalysed Ring Opening of Polycyclic meso‐Hydrazines with Trialkylaluminium Reagents and SimplePhos Ligands
Authors: Palais Laëtitia , Bournaud Chloée , Micouin Laurent , Alexakis Alexandre 
Published: January 2010

Abstractmeso‐Hydrazines could be desymmetrised by ring‐opening reactions by using various metal catalysts to form substituted cyclopentenes, which have a high synthetic potential. Herein, we report the asymmetric copper‐catalysed ring opening of a range of polycyclic hydrazines with trialkylaluminium reagents and SimplePhos ligands with both high isolated yields and enantioselectivities of up to 95 %.
Structure‐Directing Forces in Intercluster Compounds of Cationic [Ag14(CCtBu)12Cl]+ Building Blocks and Polyoxometalates: Long‐Range versus Short‐Range Bonding Interactions
Authors: Gruber Franziska , Schulz‐Dobrick Martin , Jansen Martin 
Published: January 2010

AbstractCrystallization of [Ag14(CCtBu)12Cl][BF4] and different polyoxometalates in organic solvents yields a series of new intercluster compounds: [Ag14(CCtBu)12Cl(CH3CN)]2[W6O19] (1), (nBu4N)[Ag14(CCtBu)12Cl(CH3CN)]2[PW12O40] (2), and [Ag14(CCtBu)12Cl]2[Ag14(CCtBu)12Cl(CH3CN)]2[SiMo12O40] (3). Applying the same technique to a system starting from polymeric {[Ag3(CCtBu)2][BF4]⋅0.6 H2O}n and the polyoxometalate (nBu4N)2[W6O19] results in the formation of [Ag14(CCtBu)12(CH3CN)2][W6O19] (4). Here, the Ag14 cluster is generated from polymeric {[Ag3(CCtBu)2][BF4]⋅0.6 H2O}n during crystallization. In a similar way, [Ag15(CCtBu)12(CH3CN)5][PW12O40] (5) has been obtained from {[Ag3(CCtBu)2][BF4]⋅0.6 H2O}n and (nBu4N)3[PW12O40]. The use of charged building blocks was intentional, because at these conditions the contribution of long‐range Coulomb interactions would benefit most from full periodicity of the intercluster compound, thus favoring formation of well‐crystalline materials. The latter has been achieved, indeed. However, as a most conspicuous feature, equally charged species aggregate, which demonstrates that the short‐range interactions between the “surfaces” of the clusters represent the more powerful structure direction forces than the long‐range Coulomb bonding. This observation is of significant importance for understanding the mechanisms underlying self‐organization of monodisperse and structurally well‐defined particles of nanometer size.
ChemInform Abstract: Structural and Dynamic Properties of the Polyanionic hydrides SrAlGeH and BaAlGeH.
Authors: Kranak Verina F. , Evans Michael J. , Daemen Luke L. , Proffen Thomas , Lee Myeong H. , Sankey Otto F. , Haeussermann Ulrich 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Decomposition Pathways for the Photoactivated Anticancer Complex cis,trans,cis‐ [Pt(N3)2(OH)2(NH3)2]: Insights from DFT Calculations.
Authors: Salassa Luca , Phillips Hazel I. A. , Sadler Peter J. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation and Properties of BaxFe3‐xO4 with Spinel Structure by Mechanochemical Reaction of α‐Fe2O3 and BaCO3.
Authors: He Q. , Wang H. Z. , Wen G. H. , Sun Y. , Yao B. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective Functionalization of sp3 C—H Bonds Adjacent to Nitrogen Using (Diacetoxyiodo)benzene (DIB).
Authors: Shu Xing‐Zhong , Xia Xiao‐Feng , Yang Yan‐Fang , Ji Ke‐Gong , Liu Xue‐Yuan , Liang Yong‐Min 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bifunctional Heterogeneous Catalysis of Silica—Alumina‐Supported Tertiary Amines with Controlled Acid—Base Interactions for Efficient 1,4‐Addition Reactions.
Authors: Motokura Ken , Tanaka Satoka , Tada Mizuki , Iwasawa Yasuhiro 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Remarkable Rate Acceleration of Intramolecular Diels—Alder Reaction in Ionic Liquids.
Authors: Yanai Hikaru , Ogura Hiroshi , Taguchi Takeo 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sequential 1,3‐Dipolar Cycloadditions in the Synthesis of Novel Tri‐Spiro Cyclohexanones and Piperidin‐4‐ones.
Authors: Kumar Raju Ranjith , Loganayaki Balaganesan , Perumal Subbu 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Benzo[c]thiophene Analogues Containing Benzimidazole, Benzothiazole, and Oxazole.
Authors: Clement J. Arul , Gunasekaran Pethaiah , Mohanakrishnan Arasambattu K. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Generation and Reactions of Trifluoromethylethenyl Titanium(II) Species.
Authors: Hanamoto Takeshi , Yamada Kenji 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Enantioselective Synthesis of Optically Active Diols by Asymmetric Hydrogenation with Modular Chiral Metal Catalysts.
Authors: Kadyrov Renat , Koenigs Rene M. , Brinkmann Claus , Voigtlaender David , Rueping Magnus 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: α‐Halogenation of α,β‐Unsaturated Carbonyls and Dihalogenation of Alkenes Using Bisacetoxyiodobenzene/Pyridine Hydrohalides.
Authors: Ngatimin Marsewi , Gartshore Christopher J. , Kindler Jeremy P. , Naidu Sudha , Lupton David W. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Stereoselective Synthesis of (E)‐Octafluoro‐1,3,5‐hexatriene and (3E,5E,7E)‐Dodecafluoro‐1,3,5,7,9‐decapentaene.
Authors: Liu Qibo , Burton Donald J. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring‐Conformer Effects of the Cyclopropyl Group: First Use of trans‐(2R,3R)‐Cyclopropanecarbaldehydes as Electrophiles in Diastreoselective Baylis—Hillman Reaction.
Authors: Krishna Palakodety Radha , Kishore S. , Reddy P. Srinivas 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric [2,3]‐Wittig Rearrangement of Oxygenated Allyl Benzyl Ethers in the Presence of a Chiral Di‐tBu‐bis(oxazoline) Ligand: A Novel Synthetic Approach to THF Lignans.
Authors: Kitamura Maria , Hirokawa Yoshimi , Maezaki Naoyoshi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of (E)‐β,β‐Disubstituted Nitroalkenes.
Authors: Soltani Omid , Ariger Martin A. , Carreira Erick M. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Enantioselective Henry Reaction Catalyzed by a New Chiral C2‐Symmetric N,N′‐Bis(isobornyl)ethylenediamine—Copper Complex.
Authors: Sanjeevakumar Nalluri , Periasamy Mariappan 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Aryl Halides Using Organotitanium Nucleophiles.
Authors: Lee Hang Wai , Lam Fuk Loi , So Chau Ming , Lau Chak Po , Chan Albert S. C. , Kwong Fuk Yee 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective Synthesis of β‐Amino Ketones: A Three‐Component Mannich‐Type Reaction of Aromatic Aldehydes, Anilines, and Cyclohexanone Using Amberlyst‐15.
Authors: Das Biswanath , Kumar Avula Satya , Kanth Bommena Ravi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient and Mild Protocol for the Synthesis of 4(3)‐Substituted 3(4)‐Nitro‐1H‐pyrroles (III) and 3‐Substituted 4‐Methyl‐2‐tosyl‐1H‐pyrroles (IV) from Nitroolefins and Tosylmethyl Isocyanide in Ionic Liquids.
Authors: Qin Jie , Zhang Ji , Wu Bo , Zheng Zhangguo , Yang Meng , Yu Xiaoqi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Direct Acetoxylation Of Indoles.
Authors: Mutule Ilga , Suna Edgars , Olofsson Kristofer , Pelcman Benjamin 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.