bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional scaling of sea surface temperature with global warming levels in the CMIP6 ensemble
Authors: Milovac Josipa , Iturbide Maialen , Fernández Jesús , Gutiérrez José Manuel , Diez-Sierra Javier , Jones Richard G. 
Published: April 2024

AbstractSea surface temperature (SST) and sea surface air temperature (SSAT) are commonly used as proxies for investigating the impact of climate change on oceans. These variables have been warming since pre-industrial times and are expected to continue to warm in the future under all Shared Socioeconomic Pathways (SSPs). However, they are warming in a spatially heterogeneous way, even with some cooling spots. In this work, we provide a general overview on the regional scaling of SST and SSAT with global warming, based on a 26-member CMIP6 ensemble. We utilize the global warming level (GWL) as a climate change dimension to analyze scaling patterns between sea temperature anomalies and the corresponding GWLs during the 21st century. This analysis is conducted globally, regionally, and on grid-point basis. The results show that SST and SSAT scale linearly with GWL at global scale, with scaling factors $$\beta $$
β
= 0.71 ± 0.001 K/K and $$\beta $$
β
= 0.86 ± 0.001 K/K, respectively. These results are robust, showing only minor differences between seasons, SSPs, and horizontal model resolutions. However, large differences emerge at regional scale, and the scaling of the two temperatures are strongly influenced by sea-ice. The lowest values are obtained for the Southern Ocean region, $$\beta $$
β
= 0.54 ± 0.005 K/K, projecting that the mean SST will increase only half as fast as the global mean temperature. These results provide valuable insight for refining the ocean IPCC reference regions, considering spatial homogeneity in terms of the regional response to global warming. A refinement of six ocean reference regions has been proposed.
Single-incision plus one-port laparoscopy surgery versus conventional multi-port laparoscopy surgery for colorectal cancer: a systematic review and meta-analysis
Authors: Kong Jian , Wu Meng-qi , Yan Shuai , Zhao Zheng-fei , Yao Hui 
Published: April 2024

Abstract
Objective
The efficacy of single-incision plus one-port laparoscopic surgery (SILS + 1) versus conventional laparoscopic surgery (CLS) for colorectal cancer treatment remains unclear. This study compares the short-term and long-term outcomes of SILS + 1 and CLS using a high-quality systematic review and meta-analysis.

Method
Literature search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, drawing from PubMed, Embase, Web of Science, and the Cochrane Library until December 10, 2023. Statistical analysis was conducted using RevMan and Stata.

Result
The review and meta-analysis included seven studies with 1740 colorectal cancer patients. Compared to CLS, SILS + 1 showed significant improvements in operation time (WMD =  − 18.33, P < 0.00001), blood loss (WMD =  − 21.31, P < 0.00001), incision length (WMD =  − 2.07, P < 0.00001), time to first defecation (WMD =  − 14.91, P = 0.009), time to oral intake (WMD =  − 11.46, P = 0.04), and time to ambulation (WMD =  − 11.52, P = 0.01). There were no significant differences in lymph node harvest, resection margins, complications, anastomotic leakage, hospital stay, disease-free survival, overall survival, and postoperative recurrence.

Conclusions
Compared to CLS, SILS + 1 demonstrates superiority in shortening the surgical incision and promoting postoperative recovery. SILS + 1 can provide a safe and feasible alternative to CLS.
The Synthetic Surfactant CHF5633 Restores Lung Function and Lung Architecture in Severe Acute Respiratory Distress Syndrome in Adult Rabbits
Authors: Mikolka Pavol , Kosutova Petra , Kolomaznik Maros , Nemcova Nikolett , Hanusrichterova Juliana , Curstedt Tore , Johansson Jan , Calkovska Andrea 
Published: April 2024

Abstract
Purpose
Acute respiratory distress syndrome (ARDS) is a major cause of hypoxemic respiratory failure in adults. In ARDS extensive inflammation and leakage of fluid into the alveoli lead to dysregulation of pulmonary surfactant metabolism and function. Altered surfactant synthesis, secretion, and breakdown contribute to the clinical features of decreased lung compliance and alveolar collapse. Lung function in ARDS could potentially be restored with surfactant replacement therapy, and synthetic surfactants with modified peptide analogues may better withstand inactivation in ARDS alveoli than natural surfactants.

Methods
This study aimed to investigate the activity in vitro and the bolus effect (200 mg phospholipids/kg) of synthetic surfactant CHF5633 with analogues of SP‐B and SP‐C, or natural surfactant Poractant alfa (Curosurf®, both preparations Chiesi Farmaceutici S.p.A.) in a severe ARDS model (the ratio of partial pressure arterial oxygen and fraction of inspired oxygen, P/F ratio ≤ 13.3 kPa) induced by hydrochloric acid instillation followed by injurious ventilation in adult New Zealand rabbits. The animals were ventilated for 4 h after surfactant treatment and the respiratory parameters, histological appearance of lung parenchyma and levels of inflammation, oxidative stress, surfactant dysfunction, and endothelial damage were evaluated.

Results
Both surfactant preparations yielded comparable improvements in lung function parameters, reductions in lung injury score, pro-inflammatory cytokines levels, and lung edema formation compared to untreated controls.

Conclusions
This study indicates that surfactant replacement therapy with CHF5633 improves lung function and lung architecture, and attenuates inflammation in severe ARDS in adult rabbits similarly to Poractant alfa. Clinical trials have so far not yielded conclusive results, but exogenous surfactant may be a valid supportive treatment for patients with ARDS given its anti-inflammatory and lung-protective effects.
Diagnostic value of neurofilaments in differentiating motor neuron disease from multifocal motor neuropathy
Authors: Wohnrade Camilla , Seeliger Tabea , Gingele Stefan , Bjelica Bogdan , Skripuletz Thomas , Petri Susanne 
Published: April 2024

Abstract
Objective
To evaluate the performance of serum neurofilament light chain (NfL) and cerebrospinal fluid (CSF) phosphorylated neurofilament heavy chain (pNfH) as diagnostic biomarkers for the differentiation between motor neuron disease (MND) and multifocal motor neuropathy (MMN).

Methods
This retrospective, monocentric study included 16 patients with MMN and 34 incident patients with MND. A subgroup of lower motor neuron (MN) dominant MND patients (n = 24) was analyzed separately. Serum NfL was measured using Ella automated immunoassay, and CSF pNfH was measured using enzyme-linked immunosorbent assay. Area under the curve (AUC), optimal cutoff values (Youden’s index), and correlations with demographic characteristics were calculated.

Results
Neurofilament concentrations were significantly higher in MND compared to MMN (p < 0.001), and serum NfL and CSF pNfH correlated strongly with each other (Spearman’s rho 0.68, p < 0.001). Serum NfL (AUC 0.946, sensitivity and specificity 94%) and CSF pNfH (AUC 0.937, sensitivity 90.0%, specificity 100%) performed excellent in differentiating MND from MMN. Optimal cutoff values were ≥ 44.15 pg/mL (serum NfL) and ≥ 715.5 pg/mL (CSF pNfH), respectively. Similar results were found when restricting the MND cohort to lower MN dominant patients. Only one MMN patient had serum NfL above the cutoff. Two MND patients presented with neurofilament concentrations below the cutoffs, both featuring a slowly progressive disease.

Conclusion
Neurofilaments are valuable supportive biomarkers for the differentiation between MND and MMN. Serum NfL and CSF pNfH perform similarly well and elevated neurofilaments in case of diagnostic uncertainty underpin MND diagnosis.
Neuroanatomical correlates of peripersonal space: bridging the gap between perception, action, emotion and social cognition
Authors: Basile Gianpaolo Antonio , Tatti Elisa , Bertino Salvatore , Milardi Demetrio , Genovese Giovanni , Bruno Antonio , Muscatello Maria Rosaria Anna , Ciurleo Rosella , Cerasa Antonio , Quartarone Angelo , Cacciola Alberto 
Published: April 2024

AbstractPeripersonal space (PPS) is a construct referring to the portion of space immediately surrounding our bodies, where most of the interactions between the subject and the environment, including other individuals, take place. Decades of animal and human neuroscience research have revealed that the brain holds a separate representation of this region of space: this distinct spatial representation has evolved to ensure proper relevance to stimuli that are close to the body and prompt an appropriate behavioral response. The neural underpinnings of such construct have been thoroughly investigated by different generations of studies involving anatomical and electrophysiological investigations in animal models, and, recently, neuroimaging experiments in human subjects. Here, we provide a comprehensive anatomical overview of the anatomical circuitry underlying PPS representation in the human brain. Gathering evidence from multiple areas of research, we identified cortical and subcortical regions that are involved in specific aspects of PPS encoding.We show how these regions are part of segregated, yet integrated functional networks within the brain, which are in turn involved in higher-order integration of information. This wide-scale circuitry accounts for the relevance of PPS encoding in multiple brain functions, including not only motor planning and visuospatial attention but also emotional and social cognitive aspects. A complete characterization of these circuits may clarify the derangements of PPS representation observed in different neurological and neuropsychiatric diseases.
Changes in periodontal parameters of splinted versus non-splinted posterior teeth during ten years of supportive periodontal therapy – A retrospective evaluation
Authors: Sonnenschein Sarah K. , Kilian Samuel , Ruetters Maurice , Ciardo Antonio , Kim Ti-Sun 
Published: April 2024

Abstract
Objectives
To compare periodontal parameters of splinted posterior teeth versus control teeth over ten years of supportive periodontal therapy (SPT) and to assess the survival rate of splints.

Material and methods
Retrospective data of 372 SPT-patients was screened for splints (composite/fiberglass-reinforced composite) in the posterior (molars/premolars) which were inserted at least ten years before due to increased tooth mobility. For each splinted tooth (test), a corresponding control tooth had to be present at the first SPT-session after splint insertion (T1). Data was assessed at T1 and ten years later (T2). Possible influencing covariates for splint survival (mobility degree/Eichner class) were tested by Cox regression. The change in clinical attachment level (ΔCAL), probing pocket depth (ΔPPD) and the testing of possible influencing covariates was analyzed by using mixed linear regression.

Results
Twenty-four patients (32 splints, 58 splinted teeth) were included. Ten test and two control teeth were lost. No differences were observed between ΔCAL and ΔPPD of test teeth compared to control teeth (ΔCAL -0.38 ± 1.90 vs. 0.20 ± 1.27 mm; ΔPPD -0.17 ± 1.18 vs. 0.10 ± 1.05 mm). Twenty-two splints fractured during the observation period (survival-rate: 31%). Mobility degree and Eichner class did not influence time until fracture.

Conclusions
Splinting of periodontally compromised and mobile posterior teeth does not have any disadvantage regarding the clinical periodontal situation when regular SPT is applied. However, splint fractures occur very often.

Clinical relevance
Splinting of posterior teeth is a treatment option in addition to active periodontal therapy when patients are disturbed by tooth mobility but splints have a high susceptibility to fracture.
Clinical Longevity of Obturators in Patients with Jaw Defects: a Retrospective Cohort Study
Authors: Zierden Karina , Koch Carolin Julia , Wöstmann Bernd , Rehmann Peter 
Published: April 2024

Abstract
Objectives
The primary objective of the present retrospective clinical study was to determine the survival time of obturators while analyzing possible influencing factors.

Materials and methods
This retrospective clinical cohort study analyzed the influence of various clinical factors on the survival probability of obturators and their follow-up outcomes using Kaplan‒Meier analysis.

Results
A total of 76 patients with 115 obturators were included in the study (47 men and 29 women, mean age 58.1 ± 18.1 years). The mean observation time was 3.0 ± 4.5 years (maximum 26.3 years). A total of 40.9% (47) of all obturators observed had to be replaced. The survival rate after 5 years was 79.5% for telescopic-crown-retained tooth-supported obturators, 86.9% for telescopic-crown-retained implant-supported obturators, 58.8% for removable full denture obturators, 22.1% for clasp-retained obturators and 0.0% for splints. The type of attachment, attendance at a regular follow-up and defect cause significantly influenced the survival of the obturators (p < .05).

Conclusions
The findings obtained in this study support the recommendation of using implant-supported obturators. Telescopic-crown attachments, either tooth- or implant-supported, seem to be favorable in terms of survival time. Attendance at a strict follow-up program seems to have a major influence on the longevity of the obturators.

Clinical relevance
The use of implant-supported obturators to cover permanent oral and maxillofacial defects is highly recommended. Additionally, the use of telescopic-crown attachments seems to be favorable in terms of survival time. Clasp-retained obturators and surgical splints should be used primarily for temporary restorations due to their shorter survival times.
Treatment patterns of antidepressants in children and adolescents in Scandinavia
Authors: Rasmussen Lotte , Jensen Peter Bjødstrup , Reutfors Johan , Furu Kari , Skurtveit Svetlana , Selmer Randi , Damkier Per , Bliddal Mette , Wesselhoeft Rikke 
Published: April 2024

Abstract
The aim of this study was to examine variations in use of antidepressants among children and adolescents in the three Scandinavian countries (Sweden, Norway, and Denmark). We identified new users of antidepressants (5–17 years) during 2007–2018 and described the annual incidence rate, treatment duration, concomitant psychotropic drug use, and the clinical setting of the prescribing physician (in Sweden and Denmark). Incident use of antidepressants increased by a factor 1.9 in Sweden, 1.3 in Norway and decreased by a factor 0.6 in Denmark during the study period. In Sweden, 58% of antidepressant users were covered by a prescription 12 months after initiation compared to 40% in Norway and 49% in Denmark. Also, 34% of Swedish antidepressant users were in continuous treatment after 12 months compared to 26% in Norway and 31% in Denmark. Concomitant use of other psychotropics was more common in Sweden (57%) than in Norway (37%) and Denmark (27%). During 2007–2018, clinicians from psychiatry settings initiated 75% of antidepressant treatments in Sweden, while this was the case for 50% of prescriptions in Denmark, although the proportion increased over time. The number of new antidepressant users is high and still rising in Sweden compared to Norway and Denmark. Swedish antidepressant users are more likely to use other psychotropics and to be covered by an antidepressant prescription after one year. Most antidepressants in Sweden are prescribed by physicians within psychiatric settings suggesting that they are based on specialized psychiatric evaluation.
Hooded crows (Corvus cornix) manufacture objects relative to a mental template
Authors: Smirnova Anna A. , Bulgakova Leia R. , Cheplakova Maria A. , Jelbert Sarah A. 
Published: April 2024

Abstract
It was recently found that not only tool-specialized New Caledonian crows, but also Goffin cockatoos can manufacture physical objects in accordance with a mental template. That is, they can emulate features of existing objects when they manufacture new items. Both species spontaneously ripped pieces of card into large strips if they had previously learned that a large template was rewarded, and small strips when they previously learned that a small template was rewarded. Among New Caledonian crows, this cognitive ability was suggested as a potential mechanism underlying the transmission of natural tool designs. Here, we tested for the same ability in another non-specialised tool user–Hooded crows (Corvus cornix). Crows were exposed to pre-made template objects, varying first in colour and then in size, and were rewarded only if they chose pre-made objects that matched the template. In subsequent tests, birds were given the opportunity to manufacture versions of these objects. All three crows ripped paper pieces from the same colour material as the rewarded template, and, crucially, also manufactured objects that were more similar in size to previously rewarded, than unrewarded, templates, despite the birds being rewarded at random in both tests. Therefore, we found the ability to manufacture physical objects relative to a mental template in yet another bird species not specialized in using or making foraging tools in the wild, but with a high level of brain and cognitive development.
High PPP4C expression predicts poor prognosis in diffuse large B-cell lymphoma
Authors: Hui Xue , Li Liru , Xiong Wenjing , Liu Yue , Li Hongbin , Zhang Han , Zhao Shu , Zhang Yue 
Published: April 2024

AbstractThe significance of Protein phosphatase 4 catalytic subunit (PPP4C) in diffuse large B-cell lymphoma (DLBCL) prognosis is not well understood. This work aimed to investigate the expression of PPP4C in DLBCL, investigate the correlation between PPP4C expression and clinicopathological parameters, and assess the prognostic significance of PPP4C. The mRNA expression of PPP4C was investigated using data from TCGA and GEO. To further analyze PPP4C expression, immunohistochemistry was performed on tissue microarray samples. Correlation analysis between clinicopathological parameters and PPP4C expression was conducted using Pearson's chi-square test or Fisher's exact test. Univariate and multivariate Cox hazard models were utilized to determine the prognostic significance of clinicopathological features and PPP4C expression. Additionally, survival analysis was performed using Kaplan–Meier survival curves. In both TCGA and GEO datasets, we identified higher mRNA levels of PPP4C in tumor tissues compared to normal tissues. Upon analysis of various clinicopathological features of DLBCL, we observed a correlation between high PPP4C expression and ECOG score (P = 0.003). Furthermore, according to a Kaplan–Meier survival analysis, patients with DLBCL who exhibit high levels of PPP4C had worse overall survival (P = 0.001) and progression-free survival (P = 0.002). PPP4C was shown to be an independent predictive factor for OS and PFS in DLBCL by univariate and multivariate analysis (P = 0.011 and P = 0.040). This study's findings indicate that high expression of PPP4C is linked to a poor prognosis for DLBCL and may function as an independent prognostic factors.
“Teaching capital”– a sociological analysis of medical educator portfolios for promotion
Authors: Christensen Mette Krogh , Pedersen I. M. , Wichmann-Hansen G. 
Published: April 2024

AbstractMedical educator portfolios (MEP) are increasingly recognized as a tool for developing and documenting teaching performance in Health Professions Education. However, there is a need to better understand the complex interplay between institutional guidelines and how teachers decode those guidelines and assign value to teaching merits. To gain a deeper understanding of this dynamic, this study employed a sociological analysis to understand how medical educators aspiring to professorships use MEPs to display their teaching merits and how cultural capital is reflected in these artefacts. We collected 36 medical educator portfolios for promotion from a large research-intensive university and conducted a deductive content analysis using institutional guidelines that distinguished between mandatory (accounting for the total body of teaching conducted) and optional content (arguing for pedagogical choices and evidencing the quality, respectively). Our analysis showed that the portfolios primarily included quantifiable data about teaching activities, e.g., numbers of students, topics and classes taught. Notably, they often lacked evidence of quality and scholarship of teaching. Looking at these findings through a Bourdieusian lens revealed that teachers in this social field exchange objectified evidence of hours spent on teaching into teaching capital recognized by their institution. Our findings highlight how institutional guidelines for MEPs construct a pedagogical battlefield, where educators try to decode and exchange the “right” and recognized teaching capital. This indicates that MEPs reflect the norms and practices of the academic field more than individual teaching quality.
Identification and Validation of Basement Membrane Related LncRNA Signatures as a Novel Prognostic Model for Hepatocellular Carcinoma
Authors: Liu Xuyang , Lv Chao , Zheng Jian , Xiao Jingjing , He Nan , Du Jun , Yang Xianwu , Gu Huajian 
Published: April 2024

AbstractHepatocellular carcinoma (HCC) is a significant cancer with limited treatments and a poor prognosis, with the basement membrane (BM) playing a crucial role in its initiation and growth. This study utilized data from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases to identify basement membrane-related genes differentially expressed in HCC. Through gene co-expression analysis, BM-associated long non-coding RNAs (lncRNAs) were discovered. LncRNAs related to HCC survival were selected via univariate analysis, and a prognostic model was constructed using LASSO regression and multivariate analysis. This model effectively classified HCC patients into high and low-risk groups, uncovering significant differences in prognosis, immune response, mutation, and drug sensitivity. Six BM-related lncRNAs (GSEC, MIR4435-2HG, AC092614.1, AC127521.1, LINC02580, and AC008050.1) were validated in normal and HCC cell lines, and the key role of AC092614.1 in regulating proliferation, migration, and invasion of HCC cells in vitro was explored. This research emphasizes the prognostic and therapeutic relevance of BM-related lncRNAs in HCC, highlighting AC092614.1’s role in disease progression and as a potential target for targeted therapy.
Ethical Consumerism in Emerging Markets: Opportunities and Challenges
Authors: Kutaula Smirti , Gillani Alvina , Gregory-Smith Diana , Bartikowski Boris 
Published: April 2024

AbstractDespite the economic, social, and environmental importance of emerging countries, most existing research into ethical consumerism has focused on developed market contexts. We introduce this Special Issue (SI) and provide a comprehensive thematic literature review considering three broad categories or aspects of ethical consumerism research, (1) contexts of ethical consumption, (2) forms of ethical consumerism, and (3) approaches to explaining ethical consumer behavior. We summarize the articles of this SI as part of the thematic literature review to provide an understanding of how these articles and this SI’s overall contribute to ethical consumerism research. Each article in this SI offers new insights into a specific field of ethical consumerism while focusing on emerging market contexts. Overall, this SI expands knowledge related to the dynamics and challenges of ethical consumerism and offers future research directions in this area.