bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility functions for adaptively executing concurrent workflows
Authors: Lee Kevin , Paton Norman W. , Sakellariou Rizos , Fernandes Alvaro A. A. 
Published: November 2010

AbstractWorkflows are widely used in applications that require coordinated use of computational resources. Workflow definition languages typically abstract over some aspects of the way in which a workflow is to be executed, such as the level of parallelism to be used or the physical resources to be deployed. As a result, a workflow management system has the responsibility of establishing how best to map tasks within a workflow to the available resources. As workflows are typically run over shared resources, and thus face unpredictable and changing resource capabilities, there may be benefit to be derived from adapting the task‐to‐resource mapping while a workflow is executing. This paper describes the use of utility functions to express the relative merits of alternative mappings; in essence, a utility function can be used to give a score to a candidate mapping, and the exploration of alternative mappings can be cast as an optimization problem. In this approach, changing the utility function allows adaptations to be carried out with a view to meeting different objectives. The contributions of this paper include: (i) a description of how adaptive workflow execution can be expressed as an optimization problem where the objective of the adaptation is to maximize a utility function; (ii) a description of how the approach has been applied to support adaptive workflow execution in execution environments consisting of multiple resources, such as grids or clouds, in which adaptations are coordinated across multiple workflows; and (iii) an experimental evaluation of the approach with utility measures based on response time and profit using the Pegasus workflow system. Copyright © 2010 John Wiley & Sons, Ltd.
Photoreduction of Water by using Modified CuInS2 Electrodes
Authors: Ikeda Shigeru , Nakamura Takayuki , Lee Sun Min , Yagi Tetsuro , Harada Takashi , Minegishi Tsutomu , Matsumura Michio 
Published: November 2010

AbstractPolycrystalline CuInS2 films were fabricated by sulfurization of electrodeposited Cu and In metallic precursor films. Structural analyses revealed that the CuInS2 film formed compact agglomerates of crystallites with grain sizes of ca. 0.5–1.5 μm. Photoelectrochemical characterization revealed that the film was p‐type with a flat band potential of 0.3–0.4 V (vs Ag/AgCl at pH 4), which is suitable for water reduction but cannot be for water oxidation. Upon loading Pt deposits, the film worked as a hydrogen (H2) liberation electrode under cathodic polarization. Moreover, by introduction of n‐type thin layers such as CdS and ZnS on the CuInS2 surface before the Pt loading, appreciable improvements of H2 liberation efficiency were achieved: for the CdS modified sample, spectral response data showed incident photon to current efficiency as high as 20 % at wavelengths ranging from ca. 500 to 750 nm. Appreciable H2 evolution on this sample under potentials of power‐producing regions was also confirmed.
IC‐constrained optimization of continuous‐time Gm–C filters
Authors: Fernández‐Bootello Juan F. , Delgado‐Restituto Manuel , Rodríguez‐Vázquez Ángel 
Published: November 2010

SUMMARYThis paper presents an automated synthesis procedure for integrated continuous‐time fully‐differential Gm−C filters. Such procedure builds up on a general extended state‐space system representation which provides simple matrix algebra mechanisms to evaluate the noise and distortion performances of filters, as well as, the effect of amplitude and impedance scaling operations. The proposed technique not only addresses the dynamic range optimization under power dissipation constraints, but also accounts for other relevant integrated circuit related features, such as transconductor decomposition in unitary instances, spread of capacitances and estimated area occupation, among other characteristics. The proposed approach, implemented in the MATLAB® framework, can be also used as an exploratory tool to compare different circuit implementations for a given set of filter specifications. Copyright © 2010 John Wiley & Sons, Ltd.
Analytical synthesis and comparison of voltage‐modeNth‐order OTA‐C universal filter structures
Authors: Chang Chun‐Ming , Swamy M. N. S. 
Published: November 2010

SUMMARYComplementary single‐ended‐input operational transconductance amplifier (OTA)‐based filter structures are introduced in this paper. Through two analytical synthesis methods and two transformations, one of which is to convert a differential‐input OTA to two complementary single‐ended‐input OTAs, and the other to convert a single‐ended‐input OTA and grounded capacitor‐based one to a fully differential OTA‐based one, four distinct kinds of voltage‐modenth‐order OTA‐C universal filter structures are proposed. TSMC H‐Spice simulations with 0.35µm process validate that the new complementary single‐ended‐input OTA‐based one holds the superiority in output precision, dynamic and linear ranges than other kinds of filter structures. Moreover, the new voltage‐mode band‐pass, band‐reject and all‐pass (except the fully differential one) biquad structures, all enjoy very low sensitivities. Both direct sixth‐order universal filter structures and their equivalent three biquad stage ones are also simulated and validated that the former is not absolutely larger in sensitivity than the latter. Finally, a very sharp increment of the transconductance of an OTA is discovered as the operating frequency is very high and leads to a modified frequency‐dependent transconductance. Copyright © 2010 John Wiley & Sons, Ltd.
Companding schemes based on transforming signal statistics into trigonal distributions for PAPR reduction in OFDM systems
Authors: Wu Xinchun , Wang Jinxiang , Zhou Bin , Mao Zhigang , Gao Zhiqiang 
Published: November 2010

AbstractThis paper proposes four companding transforms to reduce the peak‐to‐average power ratio in orthogonal frequency division multiplexing systems. The four companding transforms are obtained by transforming signal statistics into four trigonal distributions. Computer simulations show that the proposed schemes can effectively improve the PAPR performance and bit error rate performance of OFDM systems. Copyright © 2010 John Wiley & Sons, Ltd.
Analysis of SER of MIMO‐MRC systems with imperfect channel estimation in the presence of non‐Rayleigh CCIs
Authors: Zhang Wei‐jiong , Guan Zhang‐jun , Zhou Xi‐lang 
Published: November 2010

AbstractIn this paper, we study the average symbol error rate (SER) for a multiple input multiple output (MIMO) maximal ratio combining (MRC) system with Rayleigh fading desired signal in the presence of non‐Rayleigh fading co‐channel interferers (CCIs) and additive white Gaussian noise (AWGN). To simulate the actual environments of wireless transmission, we assume that the transceiver only obtains imperfect channel estimation (ICE). For the cases of Nakagami and Rician fading CCIs, analytic expressions for the SER have been derived approximately by introducing the modified signal‐to‐interference and noise power ratio (SINR) that can be obtained by averaging the CCI term in the original SINR over the distribution of ICE of intended user. These formulas can provide important reference of design of MIMO diversity systems. Numerical simulations verify the effectiveness of these formulas. Copyright © 2010 John Wiley & Sons, Ltd.
Transmission control in multilateral system for teletraining
Authors: Katsura Seiichiro , Suzuyama Toshiyuki , Ohishi Kiyoshi 
Published: November 2010

AbstractRecently, preservation of the skills of experts has become a serious problem in the medical and production fields. It is difficult to acquire human motion, including touching motion, by means of a conventional visual‐based system. Touching motion is inherently bilateral, since an action is always accompanied by a reaction. Bilateral force feedback control is necessary to acquire another person's skill. This paper proposes a haptic teletraining system using multilateral force feedback control. Since the multilateral control transmits haptic information among three or more remote systems, it is possible to train multiple remote trainees simultaneously using one skilled trainer. In the proposed haptic teletraining system, each local system consists of a master‐slave system. Since a touching motion is subject to the law of action and reaction, it is possible to decompose the force information into an action force and a reaction force by using bilateral control. Thus, the skilled motion of a trainer is acquired and saved as a digital database integrated with his haptic information. The proposed system is applied to a one‐trainer/two‐trainee system. As a result, motion including contact with the environment is transmitted and trained with vivid force feedback. The experimental results show the viability of the proposed method. © 2010 Wiley Periodicals, Inc. Electron Comm Jpn, 93(12): 26–34, 2010; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10237
Low‐Nuclearity MnII Complexes Based on Pyrimidine‐4,6‐dicarboxylato Bridging Ligand: Crystal Structure, Ion Exchange and Magnetic Properties
Authors: Beobide Garikoitz , Castillo Oscar , Cepeda Javier , Luque Antonio , Pérez‐Yáñez Sonia , Román Pascual , Vallejo‐Sánchez Daniel 
Published: November 2010

AbstractThe use of 1,10‐phenanthroline (phen) has allowed the polymerisation process commonly occurring in manganese(II)/pyrimidine‐4,6‐dicarboxylate (pmdc) systems to be blocked off giving the first examples of low‐nuclearity coordination compounds containing the pmdc dianion, namely, the dimeric [Mn2(μ‐pmdc)2(H2O)2(phen)2]·8H2O compound (1) and the tetrameric [Mn4(μ‐pmdc)3(phen)4(H2O)4](X)2·11H2O[X = BF4– (2), ClO4– (3), NO3– (4)] complexes. X‐ray analyses show that the hexacoordinate MnII atoms are bridged by pmdc dianions that exhibit an asymmetric κ2N,O:κO′ coordination mode in compound 1 and adopt a bis‐bidentate κ2N,O:κ2N′,O′ binding pattern in the tetrameric units of compounds 2–4. The distorted octahedral O3N3 donor set of the metal centres in 1 is completed by two nitrogen atoms from a phenanthroline ligand and one water molecule. In the linear zigzag shaped tetrameric cations of compounds 2–4, the two inner manganese centres with a O2N4 donor set are, in addition, coordinated to two nitrogen atoms from a phenanthroline ligand, whereas the outer ones complete their O3N3 coordination environment with a bidentated phenanthroline ligand and two cis coordinated water molecules. The crystal packing of the complex units generates voids filled by hydrogen‐bonded C3‐like water chains in compound 1, whereas compounds 2–4 resemble a 3D open‐framework in which the channels are occupied by the counterions and the water molecules of crystallisation. Ion exchange tests were carried out showing that compound 4 exhibits a high capacity to capture other inorganic anions by releasing nitrates. Cryomagnetic susceptibility measurements have shown the occurrence of weak antiferromagnetic interactions (J = –0.06, –0.21, –0.26 and –0.25 cm–1 for compounds 1–4, respectively). The magneto‐structural analysis indicates that the magnetic interaction taking place through the μ‐pyrimidine ring, although being weak, predominates over the longer exchange pathway involving the two carboxylate groups of the pmdc ligand.
Chemistry of Group IV Metal Ion‐Containing Polyoxometalates
Authors: Nomiya Kenji , Sakai Yoshitaka , Matsunaga Satoshi 
Published: November 2010

AbstractThe chemistry of Group IV metal ion (TiIV, ZrIV and HfIV)‐containing polyoxometalates (POMs) is presented as a sharply focused microreview, introducing an aspect of our own research. The synthesis, structure, and solid/solution state behavior of the POMs, which are prepared by the reactions of various lacunary species of POMs with TiIV, ZrIV and HfIV atoms, are described in several sections, classified with Keggin and Dawson POM families. Because of the ionic radius of TiIV (0.75 Å), close to that of WVI (0.74 Å), the TiIV atom can fit nicely into the mono‐lacunary site of the POM, but ZrIV and HfIV atoms (0.85–0.86 Å), larger than TiIV atom, do not fit into the mono‐lacunary site of the POM. Thus, the mono‐lacunary site of the POM acts as the oxygen‐donor pentadentate ligand to the TiIV atom, whereas it acts as the tetradentate ligand to ZrIV and HfIV atoms. The TiIV atom in the POM takes on six‐coordinate geometry, whereas the ZrIV and HfIV atoms have higher coordination numbers (6, 7 and 8) due to their larger ionic radii. Consequently, most Ti‐substituted Keggin POMs are isolated as oligomers formed by corner‐sharing Ti–O–Ti bonds, whereas Zr/Hf‐containing Keggin/Dawson POMs are usually isolated as di‐, tri‐, tetra‐Zr/Hf cluster cations sandwiched between two lacunary POMs, the cluster cations of which are formed by edge‐sharing M(OH)2M (M = Zr, Hf) bonds. These compounds show quite different behavior under pH‐dependent conditions. The pH‐dependent interconversion between the dimeric and monomeric species of Ti‐substituted Dawson POMs is quite an opposite tendency from those of Zr/Hf‐containing Dawson POMs. The Ti‐substituted Dawson POM oligomers have a tendency to undergo base hydrolysis to give monomers, whereas the Zr/Hf‐containing Dawson POM oligomers have a tendency to undergo acid hydrolysis to provide monomers. In the Group IV metal ion‐containing POMs, the Zr/Hf atoms function very similarly to each other, but show quite different behavior from the Ti atom.
Development of a Novel Electrochemical Biosensor for Detection and Discrimination of DNA Sequence and Single Base Mutation in dsDNA Samples Based on PNA‐dsDNA Hybridization – a new Platform Technology
Authors: Hejazi Mohammad Saeid , Pournaghi‐Azar Mohammad Hossein , Alipour Esmaeel , Abdolahinia Elaheh Dalir , Arami Sanam , Navvah Hosnieh 
Published: November 2010

AbstractIn spite of the extensive attention paid on the development of various DNA detection strategies, very few studies have been reported regarding direct detection of DNA sequence and mutation in dsDNA. Here, we describe the feasibility of detection and discrimination of target DNA sequences and single base mutations (SBM) directly in double‐stranded oligonucleotides and PCR products without the need for denaturation of the target dsDNA samples. This goal was achieved by employing a peptide nucleic acid (PNA) chain, self‐assembled on the gold electrode as a probe, which binds to dsDNA and forms PNA‐dsDNA hybrid.
Effect of nanofillers on the flame retardant properties of a polyethylene–calcium carbonate–silicone elastomer system
Authors: Karlsson Linus , Lundgren Anna , Jungqvist Jonas , Hjertberg Thomas 
Published: November 2010

AbstractThis study shows the effects of three different nanofillers on the viscosity properties and fire behavior of a halogen‐free flame retardant system. The original system, based on ethylene‐acrylate copolymer, calcium carbonate, and a silicone elastomer, shows good flame retardant properties. One of the nanofillers, montmorillonite (MMT), significantly increases the viscosity above 250∘C, resulting in reduced dripping and decreased heat release rate. The ash residue, however, is very brittle, indicating poor interactions between the MMT and other components of the system. The second nanofiller, sepiolite, shows no improvement on the flame retardant properties of the system. Reduced dripping is observed when a small amount of the third nanofiller, polyhedral oligomeric silsesquioxane, POSS, is incorporated into the system. In this case, high silica content on the surface indicates char formation originating from the POSS. However, an increased heat release is observed when POSS is used in the system. Copyright © 2010 John Wiley & Sons, Ltd.
Legitimacy, trustee incentives, and board processes: the case of public and private non‐profit nursing homes
Authors: Dewaelheyns Nico , Eeckloo Kristof , Van Hulle Cynthia 
Published: November 2010

SUMMARYUsing a unique data set, this study explores how type of ownership (government/private) is related to processes of governance. The findings suggest that the neo‐institutional perspective and the self‐interest rationale of the agency perspective are helpful in explaining processes of governance in both government‐ and privately owned non‐profit organizations. Due to adverse incentives and the quest for legitimacy, supervising governance bodies within local government‐owned non‐profit institutions pay relatively less attention to the development of high quality supervising bodies and delegate little to management. Our findings also indicate that governance processes in private institutions are more aligned with the business model and that this alignment is likely driven by a concern to improve decision making. By contrast, our data also suggest that in local government‐owned institutions re‐election concerns of politicians–trustees are an important force in the governance processes of these institutions. In view of these adverse incentives – in contrast to the case of private organizations – a governance code is unlikely to entail much improvement in government‐owned organizations. Copyright © 2010 John Wiley & Sons, Ltd.
Sleep patterns of 7‐week‐old infants at familial risk for attention deficit hyperactivity disorder
Authors: Landau Rivka , Sadeh Avi , Vassoly Paz , Berger Andrea , Atzaba‐Poria Naama , Auerbach Judith G. 
Published: November 2010

AbstractSleep patterns of 26 seven‐week‐old boys at familial risk for attention deficit hyperactivity disorder (ADHD) and 18 control infants were compared by objective (actigraph) and subjective (maternal sleep diary) measures, over five consecutive 24‐hr periods. Actigraph findings indicated that the groups differed on stability (SD) of quiet sleep only during the day. Reports in maternal sleep diaries indicated that they also differed on stability of waking and stability of sleep duration, again only during the day. No group differences were found in terms of average scores, whether calculated for the entire 24‐hr periods, for nights, or for days. Mothers in the risk group reported that fathers were less involved in infant care than did those in the control group. These findings suggest that as early as 7 weeks of age, infants at risk for ADHD differ from controls only on stability of their sleep patterns during the day, when environmental regulatory factors are more intensive.
Integrin beta1 over‐expression associates with resistance to tyrosine kinase inhibitor gefitinib in non‐small cell lung cancer
Authors: Ju Lixia , Zhou Caicun , Li Wei , Yan Linghua 
Published: November 2010

AbstractThe epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) such as gefitinib and erlotinib have been widely used in treating patients with advanced non‐small cell lung cancer (NSCLC). However, acquired resistance to EGFR TKI almost occurs in every patient eventually. To identify its potential mechanism, we established a human NSCLC cell line PC9/AB2 which was 576‐fold decrease in gefitinib sensitivity compared with its parental PC9 cell lines. No EGFR‐T790M mutation or abnormal expression of c‐Met protein was found in PC9/AB2 cells. Over‐expression of integrin β1 was found, accompanied with increase of the cells' adhesion and migration. To further confirm the role of integrin β1 in gefitinib acquired resistance, we transferred its siRNA‐expressing plasmid and its whole cDNA expressing plasmid into PC9/AB2 and into PC9 cells, respectively. The sensitivity of NSCLC cells to gefitinib was negatively correlated with integrin β1 expression levels. All these data suggest that up‐regulation of integrin β1 might be an important factor for gefitinib resistance in NSCLC cell line PC9/AB2. J. Cell. Biochem. 111: 1565–1574, 2010. © 2010 Wiley‐Liss, Inc.
C‐terminal domain of p16INK4a is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT‐1080 fibrosarcoma cells
Authors: Fahham Najmeh , Sardari Soroush , Ostad Seyed Nasser , Vaziri Behrouz , Ghahremani Mohammad Hossein 
Published: November 2010

AbstractThe tumor suppressor p16INK4a has earned widespread attention in cancer studies since its discovery as an inhibitor of cyclin‐dependent kinases (CDKs) 4/6. Structurally, it consists of four complete ankyrin repeats, believed to be involved in CDK4 interaction. According to the previous disparities concerning the importance of domains and inactivating mutations in p16, we aimed to search for the domain possessing the functional properties of the full length protein. Upon our in silico screening analyses followed by experimental assessments, we have identified the novel minimum functional domain of p16 to be the C‐terminal half including ankyrin repeats III, IV and the C‐terminal flanking region accompanied by loops 2 and 3. Transfection of this truncated form into HT‐1080 human fibrosarcoma cells, lacking endogenous p16, revealed that it is able to inhibit cell growth and proliferation equivalent to p16INK4a. The functional analysis showed that this fragment like p16 can interact with CDK4/6, block the entry into S phase of the cell cycle and suppress growth as indicated by colony formation assay. Identification of p16 minimum functional domain can be of benefit to the future peptidomimetic drug design as well as gene transfer for cancer therapy. J. Cell. Biochem. 111: 1598–1606, 2010. © 2010 Wiley‐Liss, Inc.
Role of Bim in diallyl trisulfide‐induced cytotoxicity in human cancer cells
Authors: Lee Byeong‐Chel , Park Bae‐Hang , Kim Seog‐Young , Lee Yong J. 
Published: November 2010

AbstractThe aim of this study was to investigate the effect of garlic constituent diallyl trisulfide (DATS) on the cell‐death signaling pathway in a human breast cell line (MDA‐MB‐231). We observed that DATS (10–100 µM) treatment resulted in dose‐ and time‐dependent cytotoxicity. Treatment of MDA‐MB‐231 cells with a cytotoxicity inducing concentration of DATS (50–80 µM) resulted in an increase in the intracellular level of reactive oxygen species (ROS). Data from assay with MitoSOXTM Red reagent suggest that mitochondria are the main source of ROS generation during DATS treatment. DATS‐induced oxidative stress was detected through glutaredoxin (GRX), a redox‐sensing molecule, and subsequently GRX was dissociated from apoptosis signal‐regulating kinase 1 (ASK1). Dissociation of GRX from ASK1 resulted in the activation of ASK1. ASK1 activated a downstream signal transduction JNK (c‐Jun N‐terminal kinase)‐Bim pathway. SP600125, a JNK inhibitor, inhibited DATS‐induced Bim phosphorylation and protected cells from DATS‐induced cytotoxicity. Our results indicate that the cytotoxicity caused by DATS is mediated by the generation of ROS and subsequent activation of the ASK1‐JNK‐Bim signal transduction pathway in human breast carcinoma MDA‐MB‐231 cells. J. Cell. Biochem. 112: 118–127, 2011. © 2010 Wiley‐Liss, Inc.
Activation of signal pathways and the resistance to anti‐EGFR treatment in colorectal cancer
Authors: Chen Jiezhong , Huang Xu‐Feng , Katsifis Andrew 
Published: November 2010

AbstractColorectal cancer is the third most common cancer with a 5‐year survival rate of less than 10%. It is caused by alterations of multiple signal pathways which are affected by both genetic and environmental factors. In some cases, EGFR is important in the carcinogenesis of colorectal cancer suggesting anti‐EGFR therapy may be a potential treatment option. However, in other cases it is not effective, which may be related to its down‐stream targeted gene mutations. KRAS is highly emphasized in the literature but other mutations like Src, PIK3CA, and BRAF may also be important. Furthermore, obesity may decrease the effectiveness of anti‐EGFR treatment as it increases the risk factors for colorectal cancer. Using next‐generation sequencing technology, it may be possible to identify all gene mutations in an individual with colorectal cancer. Therefore, gene mutations affecting anti‐EGFR therapy in colorectal cancer patients can be identified. J. Cell. Biochem. 111: 1082–1086, 2010. © 2010 Wiley‐Liss, Inc.