bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Enantio‐ and Diastereoselective Cyclopropanation with tert‐Butyl α‐Diazopropionate Catalyzed by Dirhodium(II) Tetrakis[N‐tetrabromophthaloyl‐(S)‐tert‐leucinate].
Authors: Goto Takayuki , Takeda Koji , Anada Masahiro , Ando Kaori , Hashimoto Shunichi 
Published: October 2011

AbstractGenerally high diastereoselectivity is already observed in the crude mixtures.
ChemInform Abstract: Mild Nonepimerizing N‐Alkylation of Amines by Alcohols Without Transition Metals.
Authors: Guerin Claire , Bellosta Veronique , Guillamot Gerard , Cossy Janine 
Published: October 2011

AbstractThe method includes the oxidation of primary and secondary alcohols followed by imine/iminium formation upon treatment with amines and reduction with NaBH(OAc)3.
ChemInform Abstract: Atom‐Economical Chemoselective Synthesis of 1,4‐Diynes and Polysubstituted Furans/Pyrroles from Propargyl Alcohols and Terminal Alkynes.
Authors: Wang Tao , Chen Xin‐liang , Chen Li , Zhan Zhuang‐ping 
Published: October 2011

AbstractAll types of title compounds are prepared from the same propargylic alcohols and terminal alkynes.
ChemInform Abstract: Expeditious Construction of Spiro‐Pyrrolidines by an Autocatalytic One‐Pot, Five‐Component, 1,3‐Dipolar Cycloaddition of in situ Generated Azomethine Ylides and Olefinic Dipolarophiles.
Authors: Li Ming , Gong Fu‐Meng , Wen Li‐Rong , Li Zhao‐Rui 
Published: October 2011

AbstractThe title compounds are prepared by a solvothermal synthesis in a highly regio‐ and stereoselective manner involving a classical Huisgen reaction in which the azomethine ylide and olefinic dipolarophiles are simultaneously generated in situ without the need to isolate the intermediates.
ChemInform Abstract: Electrosynthesis of Fluorinated Benzo[b]thiophene Derivatives.
Authors: Yin Bin , Inagi Shinsuke , Fuchigami Toshio 
Published: October 2011

AbstractAnodic oxidation of benzo[b]thiophen‐3(2H)‐ones with Et3N·5HF in DME gives monofluorinated products in reasonable yields.
ChemInform Abstract: Regiodivergent Annulation of Alkynyl Indoles to Construct Spiro‐pseudoindoxyl and Tetrahydro‐β‐carbolines.
Authors: Zhang Yong‐Qiang , Zhu Dao‐Yong , Jiao Zhi‐Wei , Li Bao‐Sheng , Zhang Fu‐Min , Tu Yong‐Qiang , Bi Zhigang 
Published: October 2011

AbstractThe N‐protecting group in the starting alkynyl indoles determines the reaction path.
ChemInform Abstract: Synthesis and Antibacterial Evaluation of Novel Heterocycles from 5‐Chloro‐3‐methyl‐1‐phenylpyrazole‐4‐carbaldehyde.
Authors: Siddiqui Zeba N. , Praveen Shagufta , Musthafa T. N. Mohammed 
Published: October 2011

Abstract4 Compounds of type (IV) or (VI) are prepared and screened for their antibacterial activities.
ChemInform Abstract: Synthesis of 5‐Acetyloxazoles and 1,2‐Diketones from β‐Alkoxy‐β‐ketoenamides and Their Subsequent Transformations.
Authors: Lechel Tilman , Gerhard Markus , Trawny Daniel , Brusilowskij Boris , Schefzig Luise , Zimmer Reinhold , Rabe Juergen P. , Lentz Dieter , Schalley Christoph A. , Reissig Hans‐Ulrich 
Published: October 2011

AbstractThree‐component reaction of lithiated alkoxyallenes (I) and (IX), nitriles and carboxylic acids provides access towards highly substituted β‐alkoxy‐β‐ketoenamides (IV), (XII) and (XIX).
ChemInform Abstract: Palladium‐Catalyzed Diastereo‐ and Enantioselective Synthesis of Substituted Cyclopentanes Through a Dynamic Kinetic Asymmetric Formal [3 + 2]‐Cycloaddition of Vinyl Cyclopropanes and Alkylidene Azlactones.
Authors: Trost Barry M. , Morris Patrick J. 
Published: October 2011

AbstractVinyl cyclopropane (I) is used in asymmetric cycloadditions with a range of aryl, heterocyclic, alkenyl, and alkyl substituted azlactone alkylidenes.
ChemInform Abstract: A Mild and Efficient Four Component One‐Pot Synthesis of 2,4,5‐Triphenyl‐(1H‐1‐imidazolyl)isoxazoles Catalyzed by Ceric Ammonium Nitrate.
Authors: Rajanarendar E. , Murthy K. Rama , Reddy M. Nagi 
Published: October 2011

AbstractA four‐component one‐pot reaction of benzil (I), aromatic aldehydes of type (II) or (V), isoxazole amines of type (III) or (VI), and ammonium acetate in the presence of cerium(IV) ammonium acetate is described.
ChemInform Abstract: An Efficient One‐Pot Synthesis of 3‐Aryl‐5‐methylisoxazoles from Aryl Aldehydes.
Authors: Zhu Shirong , Shi Shuhao , Gerritz Samuel W. 
Published: October 2011

AbstractThe approach includes a one‐pot combination of oxime formation, chlorination to hydroximinoyl chlorides and subsequent nitrile oxide 1,3‐dipolar cycloaddition with different dipolarophiles.
ChemInform Abstract: Synthesis of Substituted Triazolyl Curcumin Mimics that Inhibit RANKL‐Induced Osteoclastogenesis.
Authors: Park Sang‐Kyu , Oh Sangtae , Shin Hye Kyoung , Kim Seong Hwan , Ham Jungyeob , Song Jae‐Seok , Lee Seokjoon 
Published: October 2011

AbstractCu‐catalyzed Huisgen 1,3‐cycloaddition reaction between azidoarenes (I) and various alkynes leads to the title compounds (III) (22 examples).
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 195. Synthesis of Novel, Potential Analgesics Based on 4‐(Hetarylmethyl)amino‐2‐oxo‐1,2‐dihydroquinoline‐3‐carboxylic Acids.
Authors: Ukrainets I. V. , Mospanova E. V. , Savchenkova L. V. , Yankovich S. I. 
Published: October 2011

AbstractA variety of the title 4‐aminoquinoline‐3‐carboxylic acids (III) are synthesized by amination of corresponding 4‐chloroquinolinecarboxylic acid (I) with primary amines (II).
ChemInform Abstract: 10‐Alkyl‐2,7‐dinitro‐9(10H)‐acridinones by Tandem SNAr Reactions.
Authors: Bunce Richard A. , Grant Matthew T. 
Published: October 2011

AbstractTitle compounds (VI) are formed smoothly by tandem SNAr reaction while all attempts to cyclize the mono‐nitro substrate (IX) fail.
ChemInform Abstract: 6,7‐Dimethoxy‐3,4‐dihydroisoquinolin‐1(2H)‐ylidenoacetonitrile in Some Fusion Reactions.
Authors: Afon'kin A. A. , Kostrikin M. L. , Shumeiko A. E. , Popov A. F. 
Published: October 2011

AbstractA series of 1,2‐heterofused 6,7‐dimethoxytetrahydroisoquinoline derivatives is synthesized by reaction of title compound (I) with versatile dielectrophiles.
ChemInform Abstract: Palladium‐Catalyzed C—C Coupling Reactions of 3,5‐Dichloro‐4H‐1,2,6‐thiadiazin‐4‐one.
Authors: Ioannidou Heraklidia A. , Kizas Christos , Koutentis Panayiotis A. 
Published: October 2011

AbstractA wide range of derivatives is prepared via Suzuki—Miyaura, Stille and Sonogashira coupling from the parent (I).
Hydrothermal Carbonization: A Review
Authors: Glasner Christoph , Deerberg Görge , Lyko Hildegard 
Published: October 2011

AbstractDie hydrothermale Carbonisierung (HTC) eröffnet eine verfahrenstechnisch praktikable Möglichkeit, um aus einer Vielzahl von organischen Rest‐ und Abfallstoffen wertvollere Produkte zu erzeugen. Diese können Humus oder eine Art Biokohle sein, die als lagerfähiger und leicht zu transportierender Brennstoff oder evtl. als Bodenverbesserer genutzt werden kann. Darüber hinaus können spezialisierte, nanostrukturierte Materialien hergestellt werden. Im Gegensatz zu anderen Prozessen der Biomasseumwandlung sind die Anforderungen an den Rohstoff relativ gering. Besonders für feuchte Biomasse mit geringen Anteilen an reinen Wertstoffen wie Pflanzenöl, Stärke oder Zucker bietet sich die HTC an. Der Beitrag fasst den Stand des Wissens zusammen und ergänzt an geeigneten Stellen durch eigene Untersuchungen.
Non‐Adsorbing Macromolecules in Plasma Induce Erythrocyte Adhesion to the Endothelium
Authors: Yang Yang , Koo Stephanie , Xia Yun , Venkatraman Subbu , Neu Björn 
Published: October 2011

AbstractRed blood cell (RBC) adhesion to the endothelium is usually insignificant. However, an enhanced adhesion can be observed in various pathological conditions such as diabetes mellitus or sickle cell disease, which is often accompanied by elevated levels of pro‐adhesive plasma proteins such as fibrinogen. In the past, these proteins have only been considered to act as ligands, cross‐linking the corresponding receptors on adjacent cells, but the detailed underlying mechanism often remained obscure. This work demonstrates that the presence of non‐adsorbing polymers in plasma can also enhance the adhesion efficiency of RBCs to endothelial cells (ECs) through depletion interaction. Furthermore, adhesion of RBCs to ECs may be likewise promoted by the protein fibrinogen through depletion interaction. We propose an alternative mechanism for the pro‐adhesive effects of plasma proteins and indicate that depletion interaction might play a significant role for the stabilization and destabilization of blood flow in health and disease.
The Chemistry of Bioluminescence: An Analysis of Chemical Functionalities
Authors: Navizet Isabelle , Liu Ya‐Jun , Ferré Nicolas , Roca‐Sanjuán Daniel , Lindh Roland 
Published: October 2011

AbstractFirefly luciferase is one of the most studied bioluminescent systems, both theoretically and experimentally. Herein we review the current understanding of the bioluminescent process from a chemical functionality perspective based on those investigations. Three key components are emphasized: the chemiluminophore, the electron‐donating fragment, and how these are affected by the substrate–enzyme interaction. The understanding is based on details of how the peroxide OO bond supports the production of electronically excited products and how the charge‐transfer (CT) mechanism, with the aid of an electron‐donating group, lowers the activation barrier to support a reaction occurs in living organisms. For the substrate–enzyme complex it is demonstrated that the enzyme can affect the hydrogen‐bonding around the CT‐controlling group, resulting in a mechanism for color modulation. Finally, we analyse other luciferin–luciferase systems and compare them to the key chemical functionalities of the fragments of the luciferin–luciferase complex with respect to similarities and differences.
Dielectric Properties of Lead‐Free BZT–KNN Perovskite Ceramics for Energy Storage
Authors: Gui Dong‐Yun , Liu Han‐Xing , Hao Hua , Sun Yue , Cao Ming‐He , Yu Zhi‐Yong 
Published: October 2011

AbstractLead‐free (1−x)Ba(Zr0.15Ti0.85)O3–x(K0.5Na0.5)NbO3; x=0–0.05) (BZT–KNN) perovskite ceramics, a materials with potential applications for energy storage, are investigated. The samples are prepared by a solid‐state reaction method. Powder X‐ray diffraction (XRD) and scanning electron microscopy (SEM) are used to study the microstructure of the samples. Their dielectric properties and impedance spectra are reported as functions of temperature and frequency. The addition of 1 mol % (K0.5Na0.5)NbO3 to Ba(Zr0.15Ti0.85)O3 improves the dielectric constant and enhances its diffuseness in a wide temperature range. The small amount of (K0.5Na0.5)NbO3 is found to markedly affect the microstructure of the Ba(Zr0.15Ti0.85)O3 ceramic (grain size and other characteristics) without changing the phase or crystal symmetry. In addition, we report that fine substructures in the grains, so‐called sheet structures, are responsible for the dielectric properties (both diffuseness and dielectric constant) of (1−x)Ba(Zr0.15Ti0.85)O3–x(K0.5Na0.5)NbO3 (x=0–0.03; especially x=0.01) ceramics.
RC models of a constant phase element
Authors: Valsa Juraj , Vlach Jiri 
Published: October 2011

SUMMARYThe paper describes models of a constant‐phase element consisting of passive R and C components. The models offer any input impedance argument (phase) between −90° and 0° over a selectable frequency band covering several decades. The design procedure makes it possible to choose values of average phase, phase ripple, frequency bandwidth, and total number of R and C elements. The model can cover three frequency decades with as few as five resistors and five capacitors. The models can be used for practical realization of fractional analog differentiators and integrators, fractional oscillators, chaotic networks or for analog simulation of fractional control systems. Copyright © 2011 John Wiley & Sons, Ltd.
A complementary metal–oxide semiconductor digitally programmable current conveyor
Authors: Alzaher Hussain , Tasadduq Noman , Al‐Ees Osama , Al‐Ammari Fares 
Published: October 2011

SUMMARYA second‐generation current conveyor with digitally programmable current gains is presented. A current division network with zero standby power consumption is utilized in two different ways to provide both gain and attenuation of the second‐generation current conveyor's current transfer characteristics. The proposed topology overcomes several drawbacks of the previous solutions through affording a more power and area efficient solution while exhibiting relatively wider tuning range and bandwidth. A variable‐gain amplifier and a two‐integrator‐loop filter biquad providing low‐pass and band‐pass responses are given as application examples. A modified two‐integrator‐loop topology is developed to offer independent control of the pole frequency and quality factor without disturbing the passband gain. Simulation results obtained from a standard 0.18 µm complementary metal–oxide semiconductor process are given. Copyright © 2011 John Wiley & Sons, Ltd.
Design space exploration for sparse matrix‐matrix multiplication on FPGAs
Authors: Lin Colin Yu , Wong Ngai , So Hayden Kwok‐Hay 
Published: October 2011

SUMMARYThe design and implementation of a sparse matrix‐matrix multiplication architecture on field‐programmable gate arrays is presented. Performance of the design, in terms of computational latency, as well as the associated power‐delay and energy‐delay tradeoff are studied. Taking advantage of the sparsity of the input matrices, the proposed design allows user‐tunable power‐delay and energy‐delay tradeoffs by employing different number of processing elements (PEs) in the architecture design and different block size in the blocking decomposition. Such ability allows designers to employ different on‐chip computational architecture for different system power‐delay and energy‐delay requirements. It is in contrast to conventional dense matrix‐matrix multiplication architectures that always favor the maximum number of PEs and largest block size. In our implementation, the better energy consumption and power‐delay product favors less PEs and smaller block size for the 90%‐sparsity matrix‐matrix multiplications. Although in order to achieve better energy‐delay product, more PEs and larger block size are preferred. Copyright © 2011 John Wiley & Sons, Ltd.
A transgenic mouse line expressing cre recombinase in pancreatic β‐cells
Authors: Dahlhoff Maik , Grzech Marjeta , Habermann Felix A. , Wolf Eckhard , Schneider Marlon R. 
Published: October 2011

AbstractTransgenic mouse lines expressing Cre recombinase in a cell‐specific and tissue‐specific manner are essential tools for studying gene function and for developing suitable models for human diseases. Here, we used an expression cassette containing the full 5′ untranslated region of the porcine insulin gene to generate a mouse line expressing Cre recombinase specifically in pancreatic β‐cells by pronuclear DNA microinjection. We obtained a founder animal that transmitted the construct to its descendants in a Mendelian fashion and whose descendants showed a clear activation of β‐galactosidase expression in pancreatic β‐cells after crossing into the ROSA26 lacZ reporter mouse line. Cre expression in other organs was negative except for the kidney, intestine, and the cerebral pons where β‐galactosidase activity was detected in a small percentage of the cells. This new mouse line is a valuable tool for recombination of floxed alleles in pancreatic β‐cells in vivo. genesis 50:437–442, 2012. © 2011 Wiley Periodicals, Inc.
Olefin‐Metathesis‐Based Synthesis of Furans by an RCM/Deprotonation/Phosphorylation Sequence and Their Diels–Alder Reactions
Authors: Schmidt Bernd , Geißler Diana 
Published: October 2011

AbstractButenolides, obtained by ring‐closing metathesis (RCM) of acrylates, undergo quantitative deprotonation with amide bases. Trapping of the resulting anions with electrophiles, for example, chlorophosphates, give furans. Subsequent Diels–Alder reaction and acid‐catalysed rearrangement of the resulting oxabicyclonorbornadienes give substituted benzenes.
Triterpenoids and Limonoids from Dysoxylum lukii with Cytotoxic and Antimicrobial Activities
Authors: Hu Jiang , Wang Xiao , Shi Xiaodong 
Published: October 2011

AbstractA phytochemical investigation of a 70 % ethanol extract of the stem bark of Dysoxylum lukii has resulted in the isolation of eight new tirucallane‐type triterpenoids, one new limonoid, and five known compounds. Their structures have been elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The cytotoxic and antimicrobial properties of the isolated compounds were evaluated in vitro. Compounds 6 and 10 exhibited significant cytotoxic activity against all tested cell lines with IC50 values of 6.64–10.55 and 8.90–12.08 μM, respectively. Furthermore, compounds 6, 7, 8, 10, and 11 exhibited potent antimicrobial activity against all the Gram‐positive and Gram‐negative bacteria tested.
Sol‐Gel Derived Nanostructured Metal Oxide Platform for Bacterial Detection
Authors: Solanki Pratima R. , Patel Manoj K. , Kaushik Ajeet , Pandey M. K. , Kotnala R. K. , Malhotra B. D. 
Published: October 2011

AbstractO1 gene based 24‐mer single stranded deoxyribonucleic acid probe (ssDNA) has been immobilized onto sol‐gel derived nanostructured zirconium oxide (NanoZrO2) film fabricated onto indium‐tin‐oxide (ITO) coated glass plate to detect Vibrio cholerae. The X‐ray diffraction and Atomic Force Microscopy techniques have been used to characterize the nanostructured ZrO2 (particle size of ∼ 30–40 nm) and the ssDNA/ZrO2 bioelectrode. The hybridization of ssDNA/ZrO2 bioelectrode with the complementary and genomic DNA has been investigated using differential pulse voltammetry. The results of electrochemical studies suggest that electro‐active and cationic NanoZrO2 provides an effective surface to bind with the phosphate group of DNA resulting in enhanced electron transport. The ssDNA/NanoZrO2 bioelectrode shows a detection range from 1×10−8 to 10 nM of complementary DNA of V. cholerae within 60 s of hybridization time at 25 °C using methylene blue as an electroactive indicator. This O1 gene based metal oxide (ZrO2) sensor exhibits sensitivity for ssDNA/NanoZrO2/ITO bioelectrode as 0.48 µA/nM cm−2 for complementary DNA and 2.34 µA/nM cm−2 for genomic DNA with regression coefficients (R) of 0.991 and 0.995, respectively. This DNA bioelectrode is stable for about 15 weeks when stored at 4 °C.
Ionic liquid‐assisted SDS‐PAGE to improve human serum protein separation
Authors: Zhang Tao , Gai Qingqing , Qu Feng , Zhang Yukui 
Published: October 2011

AbstractIonic liquid (IL)‐assisted sodium dodecyl sulfate polyacrylamide gel electrophoresis (ILs‐SDS‐PAGE) was presented to improve protein separation. ILs were employed during the preparation process of polyacrylamide gel, then the modified gel was used for commercial protein marker, binary bovine serum albumin/lysozyme (BSA/Lyz) and human serum separation. The influence of ionic liquid concentration, cation alkyl chain length, cation and anion types on proteins separation were investigated. The results showed that ILs played a role in improving some protein separation, and ILs‐SDS‐PAGE provided higher resolution and separation efficiency than ordinary SDS‐PAGE for low and middle relative molecular mass proteins in human serum. In addition, the principle of ILs‐SDS‐PAGE was discussed and the comparison of ILs‐SDS‐PAGE with ordinary SDS‐PAGE and Native PAGE was made.
Technical-grade perfluorooctane sulfonate alters the expression of more transcripts in cultured chicken embryonic hepatocytes than linear perfluorooctane sulfonate
Authors: O'Brien Jason M , Austin Aislynn J , Williams Andrew , Yauk Carole L , Crump Doug , Kennedy Sean W 
Published: October 2011

Abstract
Recently it was discovered that the perfluorooctane sulfonate (PFOS) detected in wildlife, such as fish-eating birds, had a greater proportion of linear PFOS (L-PFOS) than the manufactured technical product (T-PFOS), which contains linear and branched isomers. This suggests toxicological studies based on T-PFOS data may inaccurately assess exposure risk to wildlife. To determine whether PFOS effects were influenced by isomer content, we compared the transcriptional profiles of cultured chicken embryonic hepatocytes (CEH) exposed to either L-PFOS or T-PFOS using Agilent microarrays. At equal concentrations (10 µM), T-PFOS altered the expression of more transcripts (340, &gt;1.5-fold change, p &lt; 0.05) compared with L-PFOS (130 transcripts). Higher concentrations of L-PFOS (40 µM) were also less transcriptionally disruptive (217 transcripts) than T-PFOS at 10 µM. Functional analysis showed that L-PFOS and T-PFOS affected genes involved in lipid metabolism, hepatic system development, and cellular growth and proliferation. Pathway and interactome analysis suggested that genes may be affected through the RXR receptor, oxidative stress response, TP53 signaling, MYC signaling, Wnt/β-catenin signaling, and PPARγ and SREBP receptors. In all functional categories and pathways examined, the response elicited by T-PFOS was greater than that of L-PFOS. These data show that T-PFOS elicits a greater transcriptional response in CEH than L-PFOS alone and demonstrates the importance of considering the isomer-specific toxicological properties of PFOS when assessing exposure risk. Environ. Toxicol. Chem. 2011;30:2846–2859. © 2011 SETAC
The US department of Energy's R&D program to reduce greenhouse gas emissions through beneficial uses of carbon dioxide
Authors: Damiani Darin , Litynski John T. , McIlvried Howard G. , Vikara Derek M. , Srivastava Rameshwar D. 
Published: October 2011

AbstractAs high CO2‐emitting utilities and other industries move toward implementing carbon capture and storage (CCS) technologies to manage greenhouse gas emissions, more and more CO2 will become available as a resource for multiple applications. CO2 will be a plentiful potential feedstock (carbon source) for many products, including commercial chemicals, plastics, and improved cement. Unfortunately, CO2 is a stable compound with a low energy state and does not readily participate in chemical reactions without added energy. Additionally, the supply of CO2 that may be available as the USA moves toward a carbon‐constrained economy far exceeds the current demand for CO2 as a commodity chemical. Thus, identifying candidate chemistries and economically feasible approaches that utilize large amounts of CO2 as a feedstock for high‐demand products is very challenging.The United States Department of Energy (DOE), through its National Energy Technology Laboratory (NETL), has an active carbon sequestration program. The goal of the CO2 Utilization Focus Area is to identify and develop a suite of technologies that can beneficially use CO2 to produce useful products that can generate revenue to offset capture costs associated with CCS implementation, contribute to CO2 emissions reductions, and reduce the demand for petroleum based feedstocks and products. Currently, projects being supported fall into the categories of (i) enhanced hydrocarbon recovery, (ii) chemicals production, (iii) mineralization processes for building products, and (iv) plastics production. This perspective discusses the current status of CO2 use and presents a review of DOE's program to identify and demonstrate uses for captured CO2. © 2011 Society of Chemical Industry and John Wiley & Sons, Ltd