bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPLC‐ESI‐MS/MS analysis and pharmacokinetics of luteoloside, a potential anticarcinogenic component isolated from Lonicera japonica, in beagle dogs
Authors: Qiu Feng , Li Zhaoxia , He Lang , Wang Dan 
Published: August 2012

ABSTRACTLuteoloside is a potential anticarcinogenic component isolated from Lonicera japonica, a traditional Chinese medicine (TCM). This study details the development and validation of a sensitive and accurate HPLC‐ESI‐MS/MS method for the quantification of luteoloside in dog plasma. Sample pretreatment includes simple protein precipitation using methanol–acetonitrile (1:1, v/v). A Phenomenex Gemini C18 column (2.0 × 50 mm, i.d., 3.5 µm) was used to separate luteoloside and internal standard by gradient mode with mobile phase consisting of water containing 0.1% formic acid and methanol containing 0.1% formic acid at a flow rate of 0.40 mL/min with a column temperature of 25°C. The detection was performed by positive ion electrospray ionization (ESI) in multiple reaction monitoring mode. The calibration curves were linear (R > 0.995) over the concentration range 1.0–2000 ng/mL and the lower limit of quantification was 1.0 ng/mL. The intra‐day and inter‐day precisions (RSD) were all <15%, accuracies (RE) were within the range of ±15%, and recoveries were between 85.0 and 115%. The validated HPLC‐ESI‐MS/MS method was successfully applied to determine plasma concentrations of luteoloside after intravenous administration of luteoloside at a dose level of 20 mg/kg. Copyright © 2012 John Wiley & Sons, Ltd.
Microcin C and Albomycin Analogues with Aryl‐tetrazole Substituents as Nucleobase Isosters Are Selective Inhibitors of Bacterial Aminoacyl tRNA Synthetases but Lack Efficient Uptake
Authors: Vondenhoff Gaston H. , Gadakh Bharat , Severinov Konstantin , Van Aerschot Arthur 
Published: July 2012

AbstractIn 1998, Cubist Pharmaceuticals patented a series of aminoacyl tRNA synthetase (aaRS) inhibitors based on aminoacyl sulfamoyladenosines (aaSAs), in which the adenine was substituted by aryl‐tetrazole moieties linked to the ribose fragment by a two‐carbon spacer. Although potent and specific inhibitors of bacterial IleRS, these compounds did not prove successful in vivo due to low cell permeability and strong binding to serum albumin. In this work, we attempted to improve these compounds by combining them with microcin C (McC) or albomycin (i.e., siderophore–drug conjugate (SDC)) transport modules. We found that aryl‐tetrazole variants of McC and albomycin still lacked antibacterial activity. However, these compounds were readily processed by E. coli aminopeptidases with the release of toxic aaRS inhibitors. Hence, the lack of activity in whole‐cell assays was due to an inability of the new compounds to be taken up by the cells, thus indicating that the nucleotide moieties of McC and albomycin strongly contribute to facilitated transport of these compounds inside the cell.
The A9 Core Sequence from NRPS Adenylation Domain Is Relevant for Thioester Formation
Authors: Bučević‐Popović Viljemka , Šprung Matilda , Soldo Barbara , Pavela‐Vrančič Maja 
Published: August 2012

AbstractThe adenylation (A) domain in nonribosomal peptide synthetases catalyses a two‐step reaction in which an amino acid is activated and then transferred to the neighbouring thiolation (T) domain. In this study, we investigated the role of the conserved A9 core sequence of the A‐domain of tyrocidine synthetase 1, by analysis of single amino acid mutations in the A9 region. Mutation of an absolutely conserved proline (P490G) significantly reduced the conformational stability of the protein, as evidenced by increased susceptibility to proteolytic cleavage and denaturation. All mutant A‐domains were capable of amino acid activation, but the activity in the overall reaction was reduced. Surprisingly, the S491R mutant (mutation at the first residue following the A9 motif) showed elevated overall activity compared to the wild‐type protein. Our results suggest that the A9 core sequence plays a role in the second reaction step, in which it could serve as a “clip” for the proper positioning of residues important for the interaction with the T‐domain, and/or stabilisation of the thioester‐forming conformation.
Controlled Synthesis of Nanoscale Icosahedral Gold Particles at Room Temperature
Authors: Chen Lifang , Leong G. Jeremy , Schulze Maxwell , Dinh Huyen N. , Pivovar Bryan , Hu Juncheng , Qi Zhiwen , Fang Yunjin , Prikhodko Sergey , Pozuelo Marta , Kodambaka Suneel , Richards Ryan M. 
Published: August 2012

AbstractThe shape of nanocrystals determines surface atomic arrangement and coordination, influencing their chemical and physical properties. We present a novel and facile approach to synthesize gold icosahedra by employing glucose as reducing reagent and sodium dodecyl sulfate as directing agent in the environmentally benign medium of water at room temperature. The size of the icosahedra can be controlled in the range of 30–250 nm by altering reaction conditions. High‐resolution microscopy and diffraction studies indicate the icosahedra are composed of rotational twins that owe likely to assemblage of tetrahedral units. The gold icosahedra particles catalytic properties are probed in the borohydride reduction of p‐nitrophenols and exhibit a size‐dependence reaction property. Comparison studies with spherical particles prepared by the Turkevich method, coupled with poisoning experiments, infer that the shape has a strong influence in the abundance of active surface sites as well as their activities. The properties of nanoscale icosahedra particles has promising applications for further catalytic processes, surface enhancement spectroscopic methods, chemical or biological sensing, and the fabrication of nanoscale devices.
Nonlinear Absorbing Platinum(II) Diimine Complexes: Synthesis, Photophysics, and Reverse Saturable Absorption
Authors: Liu Rui , Zhou Dapeng , Azenkeng Alexander , Li Zhongjing , Li Yuhao , Glusac Ksenija D. , Sun Wenfang 
Published: July 2012

AbstractA series of platinum(II) diimine complexes with different substituents on fluorenyl acetylide ligands (1 a–1 e) were synthesized and characterized. The influence of the auxiliary substituent on the photophysics of these complexes has been systematically investigated spectroscopically and theoretically (using density functional theory (DFT) methods). All complexes exhibit ligand‐centered 1π,π* transitions in the UV and blue spectral region, and broad, structureless 1MLCT/1LLCT (1 a, 1 b, 1 d and 1 e) or 1MLCT/1LLCT/1π,π* (1 c) absorption bands in the visible region. All complexes are emissive in solution at room temperature, with the emitting state is tentatively assigned to mixed 3MLCT/3π,π* states. The degree of 3π,π* and 3MLCT mixing varies with different substituents and solvent polarities. Complexes 1 a–1 e exhibit relatively strong singlet and triplet transient absorption from 450 to 800 nm, at which point reverse saturable absorption (RSA) could occur. Nonlinear transmission experiments at 532 nm by using nanosecond laser pulses demonstrate that 1 a–1 e are strong reverse saturable absorbers and could potentially be used as broadband nonlinear absorbing materials.
Self‐Recovery of Pd Nanoparticles That Were Dispersed over La(Sr)Fe(Mn)O3 for Intelligent Oxide Anodes of Solid‐Oxide Fuel Cells
Authors: Shin Tae Ho , Okamoto Yohei , Ida Shintaro , Ishihara Tatsumi 
Published: August 2012

AbstractSelf‐recovery is one of the most‐desirable properties for functional materials. Recently, oxide anodes have attracted significant attention as alternative anode materials for solid‐oxide fuel cells (SOFCs) that can overcome reoxidation, deactivation, and coke‐deposition. However, the electrical conductivity and surface activity of the most‐widely used oxide anodes remain unsatisfactory. Herein, we report the synthesis of an “intelligent oxide anode” that exhibits self‐recovery from power‐density degradation in the redox cycle by using a Pd‐doped La(Sr)Fe‐ (Mn)O3 cell as an oxide anode for the SOFCs. We investigated the anodic performance and oxidation‐tolerance of the cell by using Pd‐doped perovskite as an anode and fairly high maximum power densities of 0.5 and 0.1 W cm−2 were achieved at 1073 and 873 K, respectively, despite using a 0.3 mm‐thick electrolyte. Long‐term stability was also examined and the power density was recovered upon exposure of the anode to air. This recovery of the power density can be explained by the formation of Pd nanoparticles, which were self‐recovered through reoxidation and reduction. In addition, the self‐recovery of the anode by oxidation was confirmed by XRD and SEM and this process was effective for improving the durability of SOFC systems when they were exposed to severe operating conditions.
Hierarchical Structures of Carbon Nanotubes and Arrays of Chromium‐Capped Silicon Nanopillars: Formation and Electrical Properties
Authors: Koch Stefan , Joshi Ravi K. , Noyong Michael , Timper Jan , Schneider Jörg J. , Simon Ulrich 
Published: August 2012

AbstractThe formation of stochastically oriented carbon‐nanotube networks on top of an array of free‐standing chromium‐capped silicon nanopillars is reported. The combination of nanosphere lithography and chemical vapor deposition enables the construction of nanostructures that exhibit a hierarchical sequence of structural sizes. Metallic chromium serves as an etching mask for Si‐pillar formation and as a nucleation site for the formation of carbon nanotubes through the chemical vapor deposition of ethene, ethanol, and methane, respectively, thereby bridging individual pillars from top to top. Iron and cobalt were applied onto the chromium caps as catalysts for CNT growth and the influence of different carbon sources and different gas‐flow rates were investigated. The carbon nanotubes were structurally characterized and their DC electrical properties were studied by in situ local‐ and ex situ macroscopic measurements, both of which reveal their semiconductor properties. This process demonstrates how carbon nanotubes can be integrated into Si‐based semiconductors and, thus, this process may be used to form high‐surface‐area sensors or new porous catalyst supports with enhanced gas‐permeation properties.
Synthesis of Perylene Dyes with Multiple Triphenylamine Substituents
Authors: Keerthi Ashok , Liu Yeru , Wang Qing , Valiyaveettil Suresh 
Published: August 2012

AbstractPerylene monoimide (PMI) was brominated to give tetra‐ and tribrominated molecules, which underwent a Suzuki coupling reaction with 4‐(diphenylamino)phenylboronic acid to give PMI derivatives. The photophysical and electrochemical properties of the synthesized compounds were investigated, and theoretical calculations were performed. Single crystals of tetrasubstituted PMI were grown and studied in detail. The structure–property relationships were examined to reveal the effect of the position and number of substituents on the perylene core unit. All molecules showed a broad absorption up to 750 nm. Corresponding anhydrides of PMIs were used for fabrication of dye‐sensitized solar cells. The molecule with four triphenylamine units on perylene monoanhydride showed the highest power conversion efficiency.
Measuring Equilibrium Bicarbonate Concentrations Directly in Cellular Mitochondria and in Human Serum Using Europium/Terbium Emission Intensity Ratios
Authors: Smith David G , Pal Robert , Parker David 
Published: August 2012

AbstractA series of Eu and Tb complexes of four different chiral ligands incorporating an azaxanthone sensitiser has been evaluated as probes for the bicarbonate anion. Their binding affinities were assessed at ambient pH with bicarbonate, lactate, citrate, phosphate and serum albumin. Binding was signalled by modulation of circularly polarised luminescence and apparent affinity constants were measured by examining changes in emission intensity ratios. Competition experiments show that with these species and ATP present at normal physiological values, bicarbonate can be determined selectively over the concentration range 10 to 35 mM. Bicarbonate levels are also reported by using a mixture of Eu and Tb complexes of a common ligand, examining the ratio of red/green emitted light. These methods have been adapted for the determination of bicarbonate in human serum and used for the assessment of mitochondrial levels of bicarbonate in several different cell types with confocal microscopy.
Bioavailability of Metallic Impurities in Carbon Nanotubes Is Greatly Enhanced by Ultrasonication
Authors: Toh Rou Jun , Ambrosi Adriano , Pumera Martin 
Published: August 2012

AbstractMetallic impurities within carbon nanotubes (CNTs) are considered as the main cause of their toxicity. Ultrasonication is a common procedure used to purify and obtain homogeneous dispersions of CNTs as well as to mix them with other components for further processing into composites. Herein, the influence of ultrasonication upon the bioavailability of metallic impurities in CNTs was investigated. We showed that even ultrasonication times as short as 5 min significantly enhanced the bioavailability of metallic impurities, which can therefore interact more actively with biologically important molecules. These findings will have profound impact on the processing of CNTs as well as on nanotoxicity studies.
ChemInform Abstract: Structural, Electronic and Magnetic Properties of Layered REB2C Compounds (RE: Dy, Tm, Lu).
Authors: Babizhetskyy Volodymyr , Simon Arndt , Hoch Constantin , Hiebl Kurt , Le Polles Laurent , Gautier Regis , Halet Jean‐Francois 
Published: August 2012

AbstractThe isotypic title compounds are prepared from the elements (1270 K, 1 month) and the crystal structure of LuB2C is determined by powder and single crystal XRD.
ChemInform Abstract: Tetragonal YBaFe4O7.0: A Stoichiometric Polymorph of the “114” Ferrite Family.
Authors: Duffort V. , Caignaert V. , Pralong V. , Barrier N. , Raveau B. , Avdeev M. , Zheng H. , Mitchell J. F. 
Published: August 2012

AbstractThe title compound is prepared by solid state reaction of a stoichiometric mixture of BaFe2O4, Fe2O3, Y2O3, and metallic Fe (sealed silica tube, 1100 °C, 24 h).
ChemInform Abstract: New Lithium Chalcogenidotetrelates, LiChT: Synthesis and Characterization of the Li+‐Conducting Tetralithium ortho‐Sulfidostannate Li4SnS4.
Authors: Kaib Thomas , Haddadpour Sima , Kapitein Manuel , Bron Philipp , Schroeder Cornelia , Eckert Hellmut , Roling Bernhard , Dehnen Stefanie 
Published: August 2012

AbstractThe new compound Li4SnS4 (I) is synthesized from stoichiometric mixtures of Li2S, Sn, and sulfur (silica ampule, 600 °C, 24 h, 70% yield).
ChemInform Abstract: The Role of Polar, Lamdba (Λ)‐Shaped Building Units in Noncentrosymmetric Inorganic Structures.
Authors: Donakowski Martin D. , Gautier Romain , Yeon Jeongho , Moore Donald T. , Nino Juan C. , Halasyamani P. Shiv , Poeppelmeier Kenneth R. 
Published: August 2012

AbstractThe purely inorganic, polar compound (IIIb) (orthorhombic space group Pna21, Z = 4) and its centrosymmetric (triclinic space group P$\bar 1$, Z = 4) heterotypes (IIIa,c) and (V) are characterized by single crystal XRD, FTIR spectroscopy, magnetic susceptibility, impedance, and second harmonic generation measurements.
ChemInform Abstract: Gold‐ and Silver‐Catalyzed Reactions of Propargylic Alcohols in the Presence of Protic Additives.
Authors: Pennell Matthew N. , Turner Peter G. , Sheppard Tom D. 
Published: August 2012

AbstractA full account on the recently published room‐temperature Meyer—Schuster rearrangement of propargylic alcohols is presented.
ChemInform Abstract: Pyridine Is an Organocatalyst for the Reductive Ozonolysis of Alkenes.
Authors: Willand‐Charnley Rachel , Fisher Thomas J. , Johnson Bradley M. , Dussault Patrick H. 
Published: August 2012

AbstractCompared to previous two‐step procedures requiring a reaction time of 24 h, the direct reductive ozonolysis is finished within 3 minutes.
ChemInform Abstract: Friedel—Crafts Amidoalkylation via Thermolysis and Oxidative Photocatalysis.
Authors: Dai Chunhui , Meschini Francesco , Narayanam Jagan M. R. , Stephenson Corey R. J. 
Published: August 2012

AbstractGenerally, the photocatalysis provides better yields and selectivity than thermolysis.
ChemInform Abstract: Rhodium‐Catalyzed Synthesis of Branched Amines by Direct Addition of Benzamides to Imines.
Authors: Hesp Kevin D. , Bergman Robert G. , Ellman Jonathan A. 
Published: August 2012

AbstractIn contrast to the pyrrolidine amide moiety (Pya), other directing groups such as dialkyl amides decrease the yields.
ChemInform Abstract: Efficient and Regioselective Ring‐Opening of Arylaziridines with Alcohols, Thiols, Amines and N‐Heteroaromatic Compounds Using Sulfated Zirconia.
Authors: Llaveria Josep , Espinoza Araceli , Negron Guillermo , Matheu M. Isabel , Castillon Sergio 
Published: August 2012

AbstractThe products resulting from nucleophilic attack at the benzylic position are obtained as major products.
ChemInform Abstract: Solvent‐Free, N,N′‐Carbonyldiimidazole (CDI) Mediated Amidation.
Authors: Verma Sanjeev K. , Ghorpade Ramarao , Pratap Ajay , Kaushik M. P. 
Published: August 2012

AbstractA simple and scalable protocol is developed for the synthesis of amides (III) by condensation of carboxylic acids with CDI providing imidazole intermediates which react with various amines.
ChemInform Abstract: Multiple Oxidative Dehydrogenative Functionalization of Arylacetaldehydes Using Molecular Oxygen as Oxidant Leading to 2‐Oxo‐acetamidines.
Authors: Zhang Chun , Zhang Liangren , Jiao Ning 
Published: August 2012

AbstractCopper‐catalyzed multiple oxidative amination of arylacetaldehydes with various aromatic amines provides an efficient access towards oxoacetamidines, e.g. (III) and (VII), in good yields.
ChemInform Abstract: Synthesis of Diaryl Disulfides via Mild Reduction of Arylsulfinates with Hydrazine Monohydrate in DMSO.
Authors: Zhu Rui‐Heng , Shi Xiao‐Xin 
Published: August 2012

AbstractThe reaction is not suitable to aliphatic sulfinates as the corresponding dialkyl disulfides are obtained in less than 10% yield.
ChemInform Abstract: Intermolecular Metal‐Free Cyclopropanation of Alkenes Using Tosylhydrazones.
Authors: Barluenga Jose , Quinones Noelia , Tomas‐Gamasa Maria , Cabal Maria‐Paz 
Published: August 2012

AbstractThe title method is optimized for each type of alkene (styrenes, dienes, enynes, and electron‐deficient alkenes).
ChemInform Abstract: Synthetic Studies with 3‐Oxo‐N‐[4‐(3‐oxo‐3‐phenylpropionylamino)‐phenyl]‐3‐phenylpropionamide.
Authors: Abdelrazek Fathy M. , Sobhy Nehal A. , Metz Peter , Bazbouz Akram A. 
Published: August 2012

AbstractTitle compound (I) and its derivative (IV) are employed for the synthesis of hitherto unknown bis‐heterocyclic amine and bis‐heterocyclic carboxamide derivatives.
ChemInform Abstract: Regioselective Synthesis and Evaluation of 3‐Alkylidene‐1,3‐dihydroisobenzofurans as Potential Antidepressant Agents.
Authors: Praveen C. , Iyyappan C. , Girija K. , Kumar K. Suresh , Perumal P. T. 
Published: August 2012

AbstractPhthalanes (II) and (IV) are obtained regio‐, stereo‐, and chemoselectively by Cu(II)‐catalyzed cycloisomerization of 2‐ethynylbenzyl alcohols.
ChemInform Abstract: Scandium(III)‐Catalyzed Enantioselective Allylation of Isatins Using Allylsilanes.
Authors: Hanhan Nadine V. , Tang Yng C. , Tran Ngon T. , Franz Annaliese K. 
Published: August 2012

AbstractTrimethyl silanes provide best results, whereas chloro‐, methoxy‐ or aryl‐substituted silanes give rise to lower yields and decreasing enantioselectivities.
ChemInform Abstract: Use of Copper(I) Catalyzed Azide Alkyne Cycloaddition (CuAAC) for the Preparation of Conjugated Pyrrolo[2,3‐a]carbazole Pim Kinase Inhibitors.
Authors: Letribot Boris , Akue‐Gedu Rufine , Santio Niina M. , El‐Ghozzi Malika , Avignant Daniel , Cisnetti Federico , Koskinen Paivi J. , Gautier Arnaud , Anizon Fabrice , Moreau Pascale 
Published: August 2012

AbstractNew pyrrolocarbazole‐3‐carbaldehydes, substituted at the N‐10 position, are synthesized and evaluated for their ability to inhibit Pim kinases in vitro.
ChemInform Abstract: CuI‐Catalyzed One‐Pot Synthesis of Benzothiazolones from 2‐Iodoaniline‐Derived Carbamates and Sodium Sulfide.
Authors: Li Jiaojiao , Zhang Yihua , Jiang Yongwen , Ma Dawei 
Published: August 2012

AbstractThe two‐step approach allows the preparation of various benzothiazole structures with a broad spectrum of functionalities.
ChemInform Abstract: Synthesis of 2‐N‐Substituted Benzothiazoles via Domino Condensation‐Hetero Cyclization Process, Mediated by Copper Oxide Nanoparticles under Ligand‐Free Conditions.
Authors: Satish G. , Reddy K. Harsha Vardhan , Ramesh K. , Karnakar K. , Nageswar Y. V. D. 
Published: August 2012

AbstractThe three‐component condensation is mediated by KOH/CuO.
ChemInform Abstract: Enantioselective Construction of Spiro[2H‐pyran‐3,4′‐indoline] by a Systematic Michael/Reduction/Cyclization Sequence Triggered by the Asymmetric Conjugate Addition of Ketones to Isatylidenemalononitriles.
Authors: Zhao Hua , Lan Yu‐Bao , Liu Zhao‐Min , Wang Yong , Wang Xing‐Wang , Tao Jing‐Chao 
Published: August 2012

AbstractThe Michael addition reactions are performed with excellent enantioselectivities in the presence of a cinchona‐based chiral primary amine and L‐camphoric acid as an effective catalyst system.
ChemInform Abstract: Asymmetric Synthesis of Polysubstituted 4‐Amino‐ and 3,4‐Diaminochromans with a Chiral Multifunctional Organocatalyst.
Authors: Hou Wenduan , Zheng Bo , Chen Jun , Peng Yungui 
Published: August 2012

AbstractThe asymmetric addition of nitroolefins to salicylaldimines allows a simple and facile access to various title compounds.
ChemInform Abstract: Efficient, High‐Yield Protocol for the One‐Pot Synthesis of Benzopyran Derivatives Catalyzed by p‐TSA in Aqueous Media.
Authors: Nagarapu Lingaiah , Karnakanti Shuklachary , Bantu Rajashaker , Srindhar B. 
Published: August 2012

AbstractBenzopyran derivatives (III) are obtained in a TosOH‐catalyzed reaction of salicylaldehyde with 1,3‐cyclohexanediones in H2O as green solvent.
ChemInform Abstract: Nucleophilic Addition of β‐Amino Carbanions to Arynes: One‐Pot Synthesis of 4‐Aryl‐N‐methyl‐1,2,3,4‐tetrahydroisoquinolines.
Authors: Singh Kamal Nain , Singh Paramjit , Singh Pushpinder , Deol Yadwinder Singh 
Published: August 2012

AbstractThe novel procedure renders possible the direct C‐4 arylation of the tetrahydroisoquinoline skeleton.
ChemInform Abstract: A New Access to 3‐Substituted‐1(2H)‐isoquinolone by Tandem Palladium‐Catalyzed Intramolecular Aminocarbonylation Annulation.
Authors: Dieudonne‐Vatran Antoine , Azoulay Michel , Florent Jean‐Claude 
Published: August 2012

AbstractIf the compound (V) bears a heteroaromatic substituent or an aromatic substituent with a electron‐withdrawing group the reaction fails.
ChemInform Abstract: Synthesis of Aminopyridines and Aminopyridones by Cobalt‐Catalyzed [2 + 2 + 2] Cycloadditions Involving Yne‐Ynamides: Scope, Limitations, and Mechanistic Insights.
Authors: Garcia Pierre , Evanno Yannick , George Pascal , Sevrin Mireille , Ricci Gino , Malacria Max , Aubert Corinne , Gandon Vincent 
Published: August 2012

AbstractAbout 30 nitriles exhibiting a broad range of steric demand and electronic properties are studied in the title cycloaddition reaction to give pyrrolo‐, pyrido‐, and azepino‐fused pyridines as the desired bicyclic aminopyridines.
ChemInform Abstract: Synthesis of 4‐Aryl‐1,7‐naphthyridine‐2(1H)‐thiones by the Electrocyclic Reaction of 4‐(1‐Arylalk‐1‐enyl)‐3‐isothiocyanatopyridines Generated in situ from the Corresponding Isocyanides.
Authors: Kobayashi Kazuhiro , Kozuki Taketoshi , Suzuki Teruhiko 
Published: August 2012

AbstractFor the first time a simple and practical method for the synthesis of the title compounds (II) and (IV) is described from readily available starting materials.
ChemInform Abstract: Synthesis of Functionalized Furopyrazines as Restricted Dipeptidomimetics.
Authors: Claerhout Stijn , Sharma Sweta , Skoeld Christian , Cavaluzzo Claudia , Sandstroem Anja , Larhed Mats , Thirumal Meganathan , Parmar Virinder S. , Van der Eycken Erik V. 
Published: August 2012

AbstractThe synthesis of a furopyrazine scaffold having points of diversity is presented.