bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemistry of thienopyridines. VIII. Substitution products derived from thieno[2,3‐b] pyridine 7‐oxide
Authors: Klemm L. H. , Barnish I. T. , Zell Reinhard 
Published: May 2009

AbstractThieno[2,3‐b]pyridine (I) was concerted to the N‐oxide (II, 53%) by means of hydrogen peroxide and acetic acid. Nitration of II in sulfuric acid gave 4‐nitrothieno[2,3‐b]pyridine 7‐oxide (III, 50%), while nitration in acetic acid formed the isomeric 5‐nitrothieno[2,3‐b]pyridine 7‐oxide (IV, 54%). Compounds III and IV were reduced to the corresponding 4‐ and 5‐aminothieno[2,3‐b]pyridines, respectively. Treatment of III with acetyl chloride gave 4‐chlorothieno‐[2,3‐b]pyridine 7‐oxide (XI, 81%), convertible in two steps to 4‐(N‐substituted amino)thieno‐[2,3‐b]pyridines (especially of the 4‐dialkylaminoalkylamino type) for screening as potential antimalarial drugs. 4‐Aminothieno[2,3‐b]pyridine reacted with aromatic aldehydes to give Schiff's bases and other products. Mechanisms for some of the reactions are suggested. NMR spectral data are reported for various 4‐substituted thieno[2,3‐b]pyridine compounds.
Chlorination of quinoline
Authors: Tong Y. C. 
Published: May 2009

AbstractChlorination of Quinoline at 160–190° without solvent gave a mixture of compounds. The five major components were isolated and identified as 3,4‐dichloro‐, 3,4,6‐, 3,4,8‐trichloro‐, 3,4,6,8‐tetrachloro‐ and 3,4,6,7,8‐pentachloroquinolines.
Synthesis of organic isocyanates. I. Thermal decomposition of substituted 1,3,2,4‐dioxathiazole S‐oxides
Authors: Burk Emmett H. , Carlos Donald D. 
Published: May 2009

AbstractA new synthesis of aromatic isocyanates from hydroxamic acids is described which involves pyrolysis of the derived 1,3,2,4‐dioxathiazole S‐oxides.
De la synthèse du formyl‐2 hydroxy‐3 sélénophène et de l'acétyl‐2 hydroxy‐3 sélénophène
Authors: Morel J. , Paulmier C. , Pastour P. 
Published: May 2009

AbstractLe formyl‐2 hydroxy‐3 sélénophène et l'acétyl‐2 hydroxy‐3 sélénophène ont été synthétises par désalkylation d'éthers tert‐butoxylés; pour ces deux composés l'importance des liaisons hydrogènes est mise en évidence.
Synthesis of some derivatives of imidazo[1,2‐a]pyridine, pyrazolo[1,5‐b]imidazole, and 4‐(3H)quinazolinone from α‐ketohydrazidoyl bromides
Authors: Shawali Ahmad S. , Sami M. , Sherif S. Mourad , Párkányi Cyril 
Published: May 2009

Abstractα‐Aroyl‐N‐arylhydrazidoyl bromides 1 react with 2‐aminopyridine in ethanol and give 2‐aryl‐3‐arylazo‐imidazo[1,2‐α]pyridines 2 in 60‐75% yield. The reaction of 1 with 3‐phenyl‐5‐aminopyrazole in ethanol leads to 2,6‐diaryl‐3‐arylazo‐1H‐pyrazolo[1,5‐b]imidazoles 3 in almost quantitative yield. Also, 1 react with anthran‐ilic acid in the presence of triethylamine giving 3‐arylamino‐2‐aroyl‐4‐(3H)quinazolinones 4 in 80‐85% yield. The structures of the products were assigned and confirmed on the basis of their elemental analysis and electronic absorption, infrared and nmr spectra.
Pulse radiolysis study of the reduction of 1‐phenyl‐1‐cyanonitroethylene. Cyclization leading to 5‐amino‐4‐phenylisoxazole
Authors: Deswarte S. , Bellec C. , Pucheault J. , Ferradini C. , Gilles L. 
Published: May 2009

AbstractIt is known that the electrochemical reduction of the 1‐phenyl‐1‐cyanonitroethylene leads to the formation of a cyclic compound, the 5‐amino‐4‐phenyl isoxazole, but the mechanism of such a cyclization, which is pH dependent, is not clearly established. Pulse radiolytic methods were used to follow the various stages resulting from the reduction of the 1‐phenyl‐l‐cyanonitroethylene by the radical anion COO− in order to obtain a better understanding of the preceding reduction. The transient spectra are studied between 250 and 400 nm for times ranging from 4 microseconds to several minutes after the pulse; one of these spectra concerns the ene hydroxylamine. As expected, the changes and evolution of the spectra are pH dependent and corresponding mechanisms are proposed to explain the cyclization following the formation of the ene hydroxylamine. A general scheme is given taking into account all the results obtained.
Synthesis of 4,7,9‐trimethyl‐2H‐thieno[3,2‐g]‐1‐benzopyran‐2‐one. A psoralen isostere
Authors: Wellman George R. 
Published: May 2009

AbstractThe title compound, an isostere of 4,5′,8‐trimethylpsoralen, was prepared in good yield from 7‐[(2‐bromo‐allyl)thio]‐4,8‐dimethylcoumarin via a thio‐Claisen rearrangement. The structure of the final product was determined by proton nmr decoupling experiments.
Mass spectrometric fragmentation of saturated six membered heterocyclic systems containing two chalcogen family atoms
Authors: Kulkarni P. S. , Khan M. M. , Sturgeon G. D. , Gross M. L. 
Published: May 2009

AbstractThe mass spectra of six‐membered saturated heterocycles containing oxygen, sulphur, selenium and tellurium in the 1,4‐positions have been measured. The differing fragmentation modes have been characterized using high resolution, low voltage and metastable ion scan techniques. The important decomposition reactions of the molecular ions involve elimination of C2H4 and CH2X (X is a chalcogen atom) and formation of [C2H4X]+ and C2H5+. The propensities of these reactions vary systematically as a function of the ability of the chalcogen to stabilize a positive charge.
A new synthesis of methoxalen
Authors: Nore Pentti , Honkanen Erkki 
Published: May 2009

AbstractA new seven step synthesis of methoxalen, 9‐methoxy‐7H‐furo[3,2‐g][1]benzopyran‐7‐one, starting from 2‐chloro‐2′‐hydroxy‐3′,4′‐dimethoxyacetophenone is described. The yields in every step are good (60‐100%).
Benzo[b]naphtho[2,1‐d]thiophene (thiachrysene) derivatives as potential carcinostatic molecules
Authors: Alunni‐Bistocchi Giovanni , De Meo Giovanni , Pedini Mauro , Ricci Adolfo , Jacquignon Pierre , Croisy Alain 
Published: May 2009

AbstractAbout twenty compounds of the benzo[b]naphtho[2,1‐d]thiophene series have been synthesized, namely, 6‐amino derivatives, with the aim of biological testing as possible carcinostatic molecules.
Synthesis of 1‐substituted‐7‐hydroxyquinolinium salts
Authors: Ranganathan N. , Storey B. T. 
Published: May 2009

AbstractThe reaction of 7‐acetoxyquinoline with trifluorosulfonate esters of primary alcohols in methylene chloride or acetonitrile, followed by acid hydrolysis, provides a general synthesis of 1‐substituted‐7‐hydroxyquinolines, whose phenolate anions are fluorescent.
4‐Amino‐3‐mercapto‐4H‐1,2,4‐triazoles and propargyl aldehydes: A new route to 3‐R‐8‐aryl‐1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazepines
Authors: Heindel Ned D. , Reid Jack R. 
Published: May 2009

AbstractThe pendant amino and mercapto groups on 4‐amino‐3‐mercapto‐4H‐4H‐1,2,4‐triazoles can be cyclized by phenylpropargyl aldehydes. The aldehydes experience Michael addition of the SH to the alkyne linkage and imine formation between the NH2 and the aldehyde carbonyl to produce 3‐R‐8‐aryl‐1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazepines.
A Carbon‐13 and nitrogen‐15 NMR study of some nitrogen heterocycles
Authors: Buchman Russell , Komoroski Richard A. 
Published: May 2009

AbstractA number of phenyl‐substituted nitrogen heterocycles and the corresponding 2,6‐diethylphenyl derivatives were examined by 13C nmr in order to verify that the heterocyclic ring system was the same in both series. The heterocyclic ring carbon shifts did not differ substantially between the phenyl and 2,6‐diethylphenyl derivatives for all systems except one, where substantial differences were also seen in the 15N chemical shifts. Acetylated derivatives were prepared to confirm the cyclization mode in this latter case.
4‐(Arylaminothiocarbonyl)‐1‐(1‐o‐methoxyphenylcarbamido)‐ethylpiperazines as anticonvulsants
Authors: Pandey Bhagwan R. , Kumar Sushil , Singh Shiva P. , Parmar Surendra S. 
Published: May 2009

AbstractSeveral 4‐(arylaminothiocarbonyl)‐1‐(1‐o‐methoxyphenylcarbamido)‐ethylpiperazines were synthesized and evaluated for their anticonvulsant activity against pentylenetetrazol‐induced seizures in mice. The ability of substituted piperazines to inhibit in vitro respiratory activity of rat brain homogenates was also determined to study their structure‐activity relationship.
Chemistry of the phenoxathiins and isosterically related heterocycles. X. Correlation of the dihedral angles of phenoxathiin analogs with the 13NMR chemical shifts of the sulfur bearing la carbon
Authors: Caldwell Steven R. , Turley James C. , Martin Gary E. 
Published: May 2009

AbstractThe observation of a linear relationship between the 13C‐nmr chemical shifts of the C‐la carbon and the dihedral angle in a series of phenoxathiin analogs is reported. Presently available data, although limited, is presumed to be indicative of a more general behavior which has not been previously recognized or utilized. Extension of this observation to include other sulfur containing tricyclic systems may be expected to provide a useful means for the preliminary estimation of dihedral angles from solution 13C‐nmr measurements after suitable parameterization.
Benzomorphan related compounds. XIV. Synthesis of 2‐(2‐pyrrolylmethyl)‐ and 2‐(2‐indolylmethyl)tetrahydropyridines and cyclization to pyrrolo[3,2‐f]morphans
Authors: Bosch Joan , Mauleón David , Boncompte Fontsanta , Granados Ricardo 
Published: May 2009

AbstractThe synthesis of 2‐{2‐pyrrolylmethyl)‐ and 2‐(2‐indolylmethyl)tetrahydropyridines by condensation of 2‐cyanopyridines with appropriate pyrrole or indole derivatives followed by ketone reduction, quaternization and sodium borohydride reduction are described. The acid‐induced cyclization of 2‐(2‐pyrrolylmethyl)tetrahydropyridines affords 4,5,6,7,8,9‐hexahydro‐4,8‐methanopyrrolo[2,3‐d]azocine systems (pyrrolo[3,2‐f]‐morphans), although the method fails with N‐benzyl substituted pyrroles. The acid treatment of 2‐(2‐indolylmethyl)tetrahydropyridines and of 2‐indolyl tetrahydro‐2‐pyridyl ketones is not a suitable procedure for the preparation of indolo[3,2‐f]morphans, because of the protonation of indole nucleus or carbonyl group, respectively.
S‐demethylation of nitrogen heterocycles
Authors: Chen Shih‐Fong , Panzica Raymond P. 
Published: May 2009

AbstractWhen 3‐chloro‐4,5‐diaminopyridazine (2) was treated with sodium methylmercaptide in refluxing N,N‐dimethylformamide, two heterocycles were formed and isolated, neither of which was the expected 3‐methylthio‐4,5‐diaminopyridazine (3). A thorough spectral analysis of these heterocycles showed them to be 4‐methylthioimidazo[4,5‐d]pyridazine (5) and imidazo[4,5‐d]pyridazine‐4‐thione (6). N,N‐Dimethylformamide was found to provide the one carbon unit required for the formation of 5. The origin of 6 was shown to be a result of S‐demethylation of 5. S‐Demethylation of 3 could also be effected with sodium methylmercaptide in methyl sulfoxide without the occurrence of annulation. In methyl sulfoxide the process of demethylation was accelerated and occurred at lower temperature.
Ring transformations of 4H‐pyrans. Pyridines from 2‐amino‐4H‐pyrans
Authors: Seoane Carlos , Soto José L. , Zamorano Pilar , Quinteiro Margarita 
Published: May 2009

AbstractRing transformations of 4H‐pyrans into pyridines are reported. Treatment of 2‐amino‐4,6‐diaryl‐3,5‐dicyano‐4H‐pyrans (I) with nitrosylsulfuric acid brings about their transformation into 3,5‐dicyano‐4,6‐diaryl‐2‐pyridones (VI) which can also be obtained from α‐benzoylcinnamonitriles (IX) and cyanoacetamide. Similarly, 2‐amino‐4,6‐diaryl‐5‐carbethoxy‐3‐cyano‐4H‐pyrans (II) lead to 4,6‐diaryl‐5‐carbethoxy‐3‐cyano‐2‐pyridones (VII). Treatment of both series of pyrans with sulfuric acid results in the formation of the corresponding 3,4‐dihydro‐2‐pyridones (IV and V). Reaction of pyrans II with ammonium acetate in acetic acid yields 2‐amino‐4,6‐diaryl‐5‐carbethoxy‐3‐cyanopyridines (XII). Pyrans I undergo an entirely different type of reaction upon treatment with this reagent leading to 2,4,6‐triaryl‐3,5‐dicyano‐1,4‐dihydropyridines (XV).
Tricyclic thiazolo[3,2‐a]thiapyrano[4,3‐d]pyrimidines and related analogs as potential anti‐inflammatory agents
Authors: Rovnyak George , Shu Virginia , Schwartz Joseph 
Published: May 2009

AbstractA series of novel tricyclic thiazolo[3,2‐a]thiapyrano[4,3‐d]pyrimidines and related oxa, aza and carbo analogs of general formula 1 were prepared by a convenient addition‐cyclization reaction involving 2‐amino‐2‐thiazoline (4) and bisarylidene ketones of formula 3. Some of these compounds demonstrated antiinflammatory activity.
Synthesis of 3‐Acyl‐1,2‐benzisoxazoles
Authors: Yamamori Teruo , Hiramatsu Yoshiharu , Adachi Ikuo 
Published: May 2009

AbstractA convenient method for the synthesis of 3‐acyl‐1,2‐benzisoxazoles, which are unstable toward bases, is described. Base‐catalyzed cyclization of 2‐alkyl‐ and aryl‐1,3‐dithian‐2‐yl o‐chlorophenylketoximes 4a‐1 gave 3‐(2‐alkyl‐ and aryl‐1,3‐dithian‐2‐yl)‐1,2‐benzisoxazoles 8a‐1, which were converted into the corresponding 3‐acyl‐1,2‐benzisoxazoles 1a‐1.
Synthesis and reactions of 1‐[1‐oxido‐2‐(3,4)‐pyridinyl]‐2‐methyloxiranes with nitrogen nucleophiles
Authors: Avasthi Kamlakar , Knaus Edward E. 
Published: May 2009

AbstractReaction of 2(3,4)‐pyridinecarboxaldehydes (5) with ethylidenetriphenylphosphorane afford a mixture of stereoisomers Z‐(6) and E‐1‐[2(3,4)‐pyridinyl]‐1‐propenes (7). m‐Chloroperbenzoic acid oxidation of 6 and 7 yields a 60:40 mixture of Z‐(8) and E‐1‐[1‐oxido‐2(3,4)‐pyridinyl]‐2‐methyloxiranes (9). The regiospecific reaction of Z‐isomers 8a‐c with cyclic amines as piperidine give rise to threo‐1‐hydroxy‐1‐[1‐oxido‐2(3,4)‐pyridinyl]‐2‐(1‐piperidino)propanes (10) while the E‐isomer 9a yields erythro‐11. On tho other hand, the E‐isomers 9b and 9c having 1‐oxido‐3(4)‐pyridinyl substituents afford erythro‐12 resulting from attack by piperidine at C‐1 of the oxirane. Reductive deoxygenation using 10% palladium on charcoal and hydrogen gas effectively removed the N‐oxide substituent from the threo‐10 and erythro‐11 β‐aminoalcohols. Dilute solution ir spectroscopy indicated the existance of strong intramolecular hydrogen bonding in the β‐aminoalcohols 10 and 11. The assignment of relative configuration of diastereoisomers 10 and 11 was based on the magnitude of the vicinal coupling constant J where J threo is greater than J erythro.
Thermal decomposition of 2‐amino‐3‐aziridino‐1,4‐naphthoquinones
Authors: Antonini Ippolito , Claudi Francesco , Cristalli Gloria , Grifantini Mario , Martelli Sante 
Published: May 2009

AbstractThe course of the thermal decomposition of various 2‐amino‐3‐substituted aziridino‐1,4‐naphthoquinones (Ia‐g) was investigated. In all the cases, the thermal decomposition gave variable amounts of 2,3‐diamino‐1,4‐naphthoquinone (II) and of substituted 1,2,3,4,5,10‐hexahydrobenzo[g]quinoxaline‐5,10‐diones (IIIa‐g) with complete stereospecificity. The decomposition of the aziridines Ib,f also gave significative amounts of 2‐amino‐3‐allylamino‐1,4‐naphthoquinones (IVb,f). In the case of 2‐amino‐3‐(2′‐phenyl‐3′‐ethylaziridino)‐1,4‐naphthoquinone (Ig), the formation of trans‐1‐phenyl‐1‐butene (V), 2‐(1‐phenylpropyl)‐1H‐naphtho‐imidazole‐4,9‐dione (VI), 2‐phenyl‐3‐ethyl‐3,4,5,10‐tetrahydrobenzo[g]quinoxaline‐5,10‐dione (VII), 2‐phenyl‐3‐ethyl‐5,10‐dihydrobenzo[g]quinoxaline‐5,10‐dione (VIII), and a mixture of cis‐ and trans‐4H‐2,3,5,6‐tetra‐hydro‐2‐phenyl‐3‐ethyl‐5‐iminonaphtho[1,2‐b]oxazin‐6‐one (IX) also occurred. Hypotheses concerning the mechanism and the steric course of this reaction are given. The reaction is a general method for the stereospecific synthesis of 2,3‐disubstituted 1,2,3,4,5,10‐hexahydrobenzo[g]quinoxalines.
Chemical constitution and activity of bipyridinium herbicides. Part XIV. Reduction potential and herbicidal activity of 4,4′‐(1,3,4‐thiadiazole‐2,5‐diyl)‐ and 4,4′‐(1,3,4‐oxadiazole‐2,5‐diyl)bis(1‐methylpyridinium) diiodides
Authors: Kennedy Debra A. , Summers Lindsay A. 
Published: May 2009

AbstractThe diquaternary salts 4,4′‐(1,3,4‐thiadiazole‐2,5‐diyl)bis(1‐methylpyridinium) diiodide and 4,4′‐(1,3,4‐oxadiazole‐2,5‐diyl)bis(1‐methylpyridinium) diiodide are reduced in aqueous solution in the pH range 5.4‐8.0 to radical cations at a potential (Eo) of ‐0.39 V and ‐0.48 V, respectively. Their activity as herbicides is reported.
An improved synthesis of 1‐methyl‐2,5‐piperazinedione
Authors: Harris Thomas D. , Reilly Timothy J. , Delprincipe Joseph A. 
Published: May 2009

AbstractA new synthesis of 1‐methyl‐2,5‐piperazinedione in three steps starting from sarcosine is described. This method proceeds in higher overall yield (49%) than previous methods.
Pyridazines: (thiényl‐2)‐3 pyridazine, quelques (thiényl‐2)‐3 pyridazines substituées en 6 et systèmes à noyaux condensés dérivés
Authors: Bourguignon Jean , Bécue Christian , Queguiner Guy 
Published: May 2009

AbstractNous décrivons la synthèse de la (thiényl‐2)‐3 pyridazine et de quelques‐uns de ses dérivés substituée en 6 (éthoxy, hydrazino et azido). Certains de ces composés nous ont permis d'accéder à des systèmes à noyaux condensés (triazolo et tétrazolo pyridazines).
Chemistry of the phenoxathiins and isosterically related heterocycles. XV. Synthesis of 1‐nitrophenoxathiin and the relation of the 13C‐Nmr chemical shift of the alpha‐carbon to the dihedral angle
Authors: Turley James C. , Martin Gary E. 
Published: May 2009

AbstractThe synthesis of the previously unreported 1‐nitrophenoxathiin is described. The 13C‐nmr spectrum of the title compound is assigned based on chemical shift additivities and 1H‐13C spin‐coupling constants. From the observed 13C‐nmr chemical shift of the alpha‐carbon the title compound was predicted to have a molecular dihedral angle, Ø = 143.3°, based on a recently described interrelation between the alpha‐carbon 13C‐nmr chemical shift and the dihedral angle. Independent measurement of the dihedral angle in a crystallographic study has shown that there are two independent molecules contained in the assymetric unit which posess dihedral angles, Ø = 145.7 and 163.4°, the former in excellent agreement with the angle predicted by the assigned 13C‐nmr data.
A photochemical synthesis of 11H‐benzo[a]carbazole
Authors: Olsen Robert J. , Cummings O. William 
Published: May 2009

Abstract11H‐Benzo[a]carbazole was prepared from 5‐acetamido‐1,2,3,4‐tetrahydronaphthalene in four steps. A Goldberg arylation followed by hydrolysis afforded N‐phenyl‐1,2,3,4‐tetrahydro‐5‐naphthylarnine (3). Photolysis of 3 produced 1,2,3,4‐tetrahydro‐11H‐benzo[a]carbazole (4) which was converted to 11H‐benzo[a]‐carbazole by dehydrogenation with chloranil.
Reissert compound studies. XL. The first monocyclic reissert compounds
Authors: Veeraraghavan Seshadri , Bhattacharjee Debkumar , Popp Frank D. 
Published: May 2009

AbstractPyridazine and pyrimidine have been reacted with trimethylsilyl cyanide and benzoyl chloride to give the first examples of Reissert compounds derived from monocyclic systems.
The unusual formation of pyrrolo[1,2‐a]pyrazines in the reaction of alkylpyrazine anions with trans‐1,2‐dichloroethylene
Authors: Houminer Yoram 
Published: May 2009

AbstractThe reaction of alkylpyrazine anions with trans‐1,2‐dichloroethylene produces pyrrolo[1,2‐a]pyrazines in low yields.
Ètude des reactions de nitration de l'acetamido‐3 ethyl‐9 carbazole
Authors: Lancelot Jean‐Charles , Gazengel Jean‐Marie , Robba Max 
Published: May 2009

AbstractLa première nitration de l'acétamido‐3 éthyl‐9 carbazole (1c) s'effectue en position 6 alors que le formamido‐3 et le N‐carbéthoxyamino‐3 éthyl‐9 carbazole (1b) et (1d) sont nitrés initialement sur le sommet 4. Le formarnido‐3 éthyl‐9 carbazole (1b) peut subir une dinitration en 4 et en 6 de měme que l'acétamido‐3 et le N‐carbethoxyamino‐3 éthyl‐9 carbazole qui donnent également des dérivés trinitrés 7b et 7c. Les structures sont établies par voie chimique et au moyen des spectres de rmn.
Functionalization of the 4(5)methyl group of imidazoles: A novel synthesis of substituted imidazoles
Authors: Webb R. Lee , Lewis Joseph J. 
Published: May 2009

AbstractAcyl vinyl phosphonium salts react with amidines to form imidazolyl phosphonium salts. These imidazolyl salts can be readily converted to multifunctional imidazoles with quantitative recovery of triphenyl phosphine.
Synthesis and properties of 1‐Benzothiopyrano[2,3‐d]‐pyrimidine‐2,4‐(3H)diones (10‐thia‐5‐deazaflavins)
Authors: Yoneda Fumio , Tsukuda Kinshiro , Kawazoe Michiko , Sone Atsuko , Koshiro Akira 
Published: May 2009

AbstractTreatment of 6‐arylthiouracils with the Vilsmeier reagent (dimethylformamide‐phosphorus oxychloride) gave the corresponding 6‐arylthio‐5‐formyluracils, which could alternatively be prepared by the condensation of 6‐chloro‐5‐formyluracils with thiophenols. Dehydrative cyclization of the above 5‐formyluracils with polyphosphoric acid gave 1‐benzothiopyrano[2,3‐d]pyrimidine‐2,4‐(3H)diones (10‐thia‐5‐deazaflavins). These 10‐thia‐5‐deazaflavins oxidized alcohols to give the corresponding carbonyl compounds with the aid of strong base, and they were hydrogenated to 1,5‐dihydro‐10‐thia‐5‐deazaflavins. Treatment of 10‐thia‐5‐deazaflavins with concentrated aqueous potassium hydroxide led to the exclusive formation of 1,5‐dihydro‐10‐thia‐5‐deazaflavins and 1,5‐dihydro‐10‐thia‐5‐deazaflavin‐5‐ones via intermolecular oxidation‐reduction (disproportionation) between initially formed 1,5‐dihydro‐5‐hydroxy‐10‐thia‐5‐deazaflavins and unchanged 10‐thia‐5‐deazaflavins.
Amination of 2,6‐ and 2,7‐Naphthyridine. An NMR study on σ‐Adducts of heterocyclic systems with amide ions
Authors: Van Den Haak Henk J. W. , Van Der Plas Henk C. , Van Veldhuizen Beb 
Published: May 2009

AbstractA facile synthesis of 2,6‐naphthyridine is described. Both 2,6‐ and 2,7‐naphthyridine undergo with potassium amide under kinetically and thermodynamically controlled conditions σ‐adduct formation at position 1. Chichibabin amination of 2,6‐naphthyridine yields 1‐amino‐2,6‐naphthyridine in 54% yield.
Synthesis of bridgeheaded nitrogen systems. s‐triazolo[4,3‐b]‐as‐triazine, s‐triazolo[4,3‐d]‐as‐triazine and s‐triazolo[3,4‐b]‐1,3,4‐Thiadiazole ring systems
Authors: Sasaki Tadashi , Ito Eikoh 
Published: May 2009

AbstractBy the reactions of hydrazino‐as‐triazines (1a‐d and 5) with cyanogen bromide were synthesized s‐triazolo‐as‐triazines (2a‐d) and (6). Likewise, similar reactions of amino‐s‐triazolethiols (7a‐e) gave s‐triazolo‐1,3,4‐thiadiazoles (8a‐e). Compound 2a was brominated to 2g.
Synthèse d'acétyl‐6 et benzoyl‐6 indoles
Authors: Ta Kim Phieo , Guilard Roger , Dodey Pierre , Sornay Roland 
Published: May 2009

AbstractLa synthèse d'acétyl‐6 et benzoyl‐6 indoles a été réalisée via la réaction de Hemetsberger. Quelques aspects de leur réactivité sont envisagés.
Conversion of 3,7‐Dialkoxy‐4H,8H‐benzo[l,2‐c:4,5‐c']diisoxazole‐4,8‐dione into new heterocyclic systems
Authors: Neidlein R. , Throm S. 
Published: May 2009

AbstractTreatment of 1a or 1b with concentrated acids yielded the acid 3, with alkali hydrogen carbonates the sodium salt 7 and the potassium salt 8; by reacting with phosphorus pentachloride the vinylogous acid chloride 9 was isolated. Reactions of 9 with amines such as N‐nucleophiles led to the corresponding amides 10, 11, 14, 15, and with alcohols such as O‐nucleophiles to the corresponding alkoxyderivatives 16a, 16b, which are isomeric compounds to 1a, 1b and 2a, 2b.
The route of action of sodium methoxide on 5‐Arylmethylene‐2‐Disubstituted amino‐4‐oxo‐2‐thiazolines
Authors: Omar M. T. , Kasem M. A. 
Published: May 2009

Abstract5‐Arylmethylene‐2‐disubstituted amino‐4‐oxo‐2‐thiazolines 1a‐d reacted with six and two moles of sodium methoxide to give the 2‐mercaptocinnamic acid esters 6 and mixtures of 2,2‐dimethoxy‐4‐oxothiazolidines 4 and 2,4‐dioxothiazolidines 5, respectively. The intermediate mixture of the sodium salt of 5‐aryImethylene‐2,2‐dimethoxy‐4‐oxothiazolidines 3 in the above mentioned transofrmations was established. The structures of 3, 4, 5 and 6 were based on analytical and spectral evidence. The route of conversion of 1 into 3, 4,5 and 6 was presented and discussed.