bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online model adaptation in Monte Carlo tree search planning
Authors: Zuccotto Maddalena , Fusa Edoardo , Castellini Alberto , Farinelli Alessandro 
Published: June 2024

AbstractWe propose a model-based reinforcement learning method using Monte Carlo Tree Search planning. The approach assumes a black-box approximated model of the environment developed by an expert using any kind of modeling framework and it improves the model as new information from the environment is collected. This is crucial in real-world applications, since having a complete knowledge of complex environments is impractical. The expert’s model is first translated into a neural network and then it is updated periodically using data, i.e., state-action-next-state triplets, collected from the real environment. We propose three different methods to integrate data acquired from the environment with prior knowledge provided by the expert and we evaluate our approach on a domain concerning air quality and thermal comfort control in smart buildings. We compare the three proposed versions with standard Monte Carlo Tree Search planning using the expert’s model (without adaptation), Proximal Policy Optimization (a popular model-free DRL approach) and Stochastic Lower Bounds Optimization (a popular model-based DRL approach). Results show that our approach achieves the best results, outperforming all analyzed competitors.
Exact solutions of the $$(2+1)$$-dimensional Zoomeron model arising in nonlinear optics via mapping method
Authors: Akgül Ali , Manzoor Saliha , Ashraf Farrah , Ashraf Romana 
Published: June 2024

AbstractThe Zoomeron model covers particular kinds of solitons with distinctive properties that appear in several physical scenarios, such as, fluid dynamics, nonlinear optics and laser physics. First time utilising the mapping method, we determine the analytical solution to the described model, including several novel dynamical behaviours. Through symbolic computation, we are able to derive the breather waves, kink waves, dark soliton, singular soliton, periodic soliton and bright soliton of this model. Additionally, we encounter single kink waves and single breather waves. We find novel hyperbolic trigonometric, rational and elliptic functions. Modelling our observations with MATLAB tools and producing many 3D graphs. The results obtained will be crucial for further research on complicated nonlinear models.
It’s About Time: The Inequitable Distribution of Time as a Resource for College, by Gender and Race/Ethnicity
Authors: Wladis Claire , Hachey Alyse C. , Conway Katherine 
Published: June 2024

AbstractExisting qualitative research in higher education on students’ work and family commitments already suggests that time as a resource for college is likely not distributed equitably by race/ethnicity or gender. However, the relationship between race/ethnicity, gender, and time as a resource for college has yet to be quantitatively measured in large-scale higher education research. This study explored whether gender or race/ethnicity correlated with differences in time as a resource for college; and further, the extent to which differences in time as a resource for college may be explained by other factors such as age, number of children, and access to childcare. Retrospective survey responses (n = 41,579) on self-reported time use were merged with institutional data records from students at the City University of New York (CUNY), a large diverse public university in the U.S. Women, Black, and Hispanic students were all significantly more time poor than male, White, or Asian students. Age accounted for significant portions of these differences, perhaps because it correlates with increased work and family responsibilities. Having children as well as a student’s access to childcare also explained a significant portion of inequitable distributions of time as a resource for college.
Upscaling and Effective Behavior for Two-Phase Porous-Medium Flow Using a Diffuse Interface Model
Authors: Kelm Mathis , Bringedal Carina , Flemisch Bernd 
Published: June 2024

AbstractWe investigate two-phase flow in porous media and derive a two-scale model, which incorporates pore-scale phase distribution and surface tension into the effective behavior at the larger Darcy scale. The free-boundary problem at the pore scale is modeled using a diffuse interface approach in the form of a coupled Allen–Cahn Navier–Stokes system with an additional momentum flux due to surface tension forces. Using periodic homogenization and formal asymptotic expansions, a two-scale model with cell problems for phase evolution and velocity contributions is derived. We investigate the computed effective parameters and their relation to the saturation for different fluid distributions, in comparison to commonly used relative permeability saturation curves. The two-scale model yields non-monotone relations for relative permeability and saturation. The strong dependence on local fluid distribution and effects captured by the cell problems highlights the importance of incorporating pore-scale information into the macro-scale equations.
Unleashed: walking dogs off the lead greatly increases habitat disturbance in UK lowland heathlands
Authors: Thomas Rebecca L. , Papworth Sarah K. , Fellowes Mark D.E. 
Published: June 2024

AbstractHuman population growth is associated with increased disturbance to wildlife. This effect is particularly acute in urban and periurban areas, where the area of effective disturbance extends beyond that of human presence by the roaming behaviour of pet dogs. Dogs are globally the dominant companion animal, with a population of ~ 12 million in the UK. As urban areas extend, dogs are exercised in green space close to housing. In southeast and southern England these areas include lowland heath, a habitat of high conservation value. To quantify disturbance caused by dog walkers and their dogs, we used GPS units to track the movement of people and their dogs across four lowland heath sites, used a questionnaire to ask about dog walking habits, and mapped potential areas of disturbance caused by dog walkers. Questionnaires were completed by 798 dog walkers and the walks of 162 owners and their 185 dogs were recorded. Mean (± SE) walk time was 56 ± 23 min, walk distance 3.75 ± 1.68 km and dogs were a median distance of 20 m from the owner during walks. Dogs were walked once (44%) or twice (56%) a day. Most (always: 85%; always or occasionally: 95%) dogs were walked off the lead even when signs were present requesting that dogs were kept on a lead. This resulted in up to a 21% increase in reserve area disturbed. In one reserve (Snelsmore Common), > 90% of the area was disturbed by dogs, greatly eroding its conservation value. This work highlights the importance of considering how dog ownership can exacerbate levels of disturbance in sensitive periurban habitats when housing developments are planned.
An update on non-aureus staphylococci and mammaliicocci in cow milk: unveiling the presence of Staphylococcus borealis and Staphylococcus rostri by MALDI-TOF MS
Authors: Penati Martina , Ulloa Fernando , Locatelli Clara , Monistero Valentina , Pavesi Laura Filippone , Santandrea Federica , Piccinini Renata , Moroni Paolo , Bronzo Valerio , Addis Maria Filippa 
Published: June 2024

AbstractNon-aureus staphylococci and mammaliicocci (NASM) are the microorganisms most frequently isolated from milk. Given their numerosity and complexity, MALDI-TOF MS is one of the preferred species identification approaches. Nevertheless, reference mass spectra for the novel species Staphylococcus borealis were included only recently in the Bruker Biotyper System (MBT) library, and other species of veterinary interest such as S. rostri are still absent. This work provides an updated picture of the NASM species found in milk, gained by retrospectively analyzing the data relating to 21,864 milk samples, of which 6,278 from clinical mastitis (CM), 4,039 from subclinical mastitis (SCM), and 11,547 from herd survey (HS), with a spectrum library including both species. As a result, S. borealis was the second most frequently isolated NASM (17.07%) after S. chromogenes (39.38%) in all sample types, with a slightly higher percentage in CM (21.84%), followed by SCM (17.65%), and HS (14.38%). S. rostri was also present in all sample types (3.34%), reaching 8.43% of all NASM in SCM and showing a significant association (p < 0.01) with this condition. Based on our findings, the presence of S. borealis and S. rostri in milk and their potential association with mastitis might have been overlooked, possibly due to the difficulties in differentiating these species from other closely related NASM. Our results indicate that S. borealis could be a more frequent contributor to bovine udder infections than previously thought and that S. rostri should also not be underestimated considering its significant association with SCM.
Rapid Assessment of Bio-distribution and Antitumor Activity of the Photosensitizer Bremachlorin in a Murine PDAC Model: Detection of PDT-induced Tumor Necrosis by IRDye® 800CW Carboxylate, Using Whole-Body Fluorescent Imaging
Authors: McMorrow Roisin , de Bruijn Henriette S. , Que Ivo , Stuurman Debra C. , de Ridder Corrina M.A. , Doukas Michail , Robinson Dominic J. , Mezzanotte Laura , Lowik Clemens W.G.M. 
Published: June 2024

AbstractPhotodynamic therapy (PDT) is a light-based anticancer therapy that can induce tumor necrosis and/or apoptosis. Two important factors contributing to the efficacy of PDT are the concentration of the photosensitizer in the tumor tissue and its preferential accumulation in the tumor tissue compared to that in normal tissues. In this study, we investigated the use of optical imaging for monitoring whole-body bio-distribution of the fluorescent (660 nm) photosensitizer Bremachlorin in vivo, in a murine pancreatic ductal adenocarcinoma (PDAC) model. Moreover, we non-invasively, examined the induction of tumor necrosis after PDT treatment using near-infrared fluorescent imaging of the necrosis avid cyanine dye IRDye®-800CW Carboxylate. Using whole-body fluorescence imaging, we observed that Bremachlorin preferentially accumulated in pancreatic tumors. Furthermore, in a longitudinal study we showed that 3 hours after Bremachlorin administration, the fluorescent tumor signal reached its maximum. In addition, the tumor-to-background ratio at all-time points was approximately 1.4. Ex vivo, at 6 hours after Bremachlorin administration, the tumor-to-muscle or -normal pancreas ratio exhibited a greater difference than it did at 24 hours, suggesting that, in terms of efficacy, 6 hours after Bremachlorin administration was an effective time point for PDT treatment of PDAC. In vivo administration of the near infrared fluorescence agent IRDye®-800CW Carboxylate showed that PDT, 6 hours after administration of Bremachlorin, selectively induced necrosis in the tumor tissues, which was subsequently confirmed histologically. In conclusion, by using in vivo fluorescence imaging, we could non-invasively and longitudinally monitor, the whole-body distribution of Bremachlorin. Furthermore, we successfully used IRDye®-800CW Carboxylate, a near-infrared fluorescent necrosis avid agent, to image PDT-induced necrotic cell death as a measure of therapeutic efficacy. This study showed how fluorescence can be applied for optimizing, and assessing the efficacy of, PDT.
Agile model-driven re-engineering
Authors: Lano Kevin , Haughton Howard , Yuan Ziwen , Alfraihi Hessa 
Published: June 2024

AbstractIn this paper we describe an Agile model-driven engineering (MDE) approach, AMDRE, for the re-engineering of legacy systems. The objective is to support the reuse of business-critical functionality from such systems and the porting of legacy code to modernised platforms, together with technical debt reduction to improve the system maintainability and extend its useful life. AMDRE uses a lightweight MDE process which involves the automated abstraction of software systems to UML specifications and the interactive application of refactoring and rearchitecting transformations to remove quality flaws and architectural flaws. We demonstrate the approach on Visual Basic, COBOL and Python legacy codes, including a finance industry case. Significant quality improvements are achieved, and translation accuracy over 80% is demonstrated. In comparison to other MDE re-engineering approaches, AMDRE does not require high MDE skills and should be usable by mainstream software practitioners.
Mathematical Assessment of the Role of Intervention Programs for Malaria Control
Authors: Korsah Maame Akua , Johnston Stuart T. , Tiedje Kathryn E. , Day Karen P. , Flegg Jennifer A. , Walker Camelia R. 
Published: June 2024

AbstractMalaria remains a global health problem despite the many attempts to control and eradicate it. There is an urgent need to understand the current transmission dynamics of malaria and to determine the interventions necessary to control malaria. In this paper, we seek to develop a fit-for-purpose mathematical model to assess the interventions needed to control malaria in an endemic setting. To achieve this, we formulate a malaria transmission model to analyse the spread of malaria in the presence of interventions. A sensitivity analysis of the model is performed to determine the relative impact of the model parameters on disease transmission. We explore how existing variations in the recruitment and management of intervention strategies affect malaria transmission. Results obtained from the study imply that the discontinuation of existing interventions has a significant effect on malaria prevalence. Thus, the maintenance of interventions is imperative for malaria elimination and eradication. In a scenario study aimed at assessing the impact of long-lasting insecticidal nets (LLINs), indoor residual spraying (IRS), and localized individual measures, our findings indicate that increased LLINs utilization and extended IRS coverage (with longer-lasting insecticides) cause a more pronounced reduction in symptomatic malaria prevalence compared to a reduced LLINs utilization and shorter IRS coverage. Additionally, our study demonstrates the impact of localized preventive measures in mitigating the spread of malaria when compared to the absence of interventions.
Cardiac tamponade – a rare cause of sudden death in autoimmune polyglandular syndrome
Authors: Tan Luzern , Gilbert John D. , Byard Roger W. 
Published: June 2024

AbstractA 27-year-old male died suddenly due to cardiac tamponade arising from pericarditis complicating autoimmune polyglandular syndrome (APS) type 2. He had a history of primary Addison disease and autoimmune hypothyroidism which were corroborated at autopsy. In addition a florid fibrinous pericarditis was associated with 287 g of turbid fluid in the pericardial sac. Although pericarditis with tamponade is a potential complication of APS, it has rarely if ever, been reported as a cause of sudden death. Lethal mechanisms may involve both compressive and restrictive effects.
Asciminib in Patients With CML-CP Previously Treated With ≥ 2 Tyrosine Kinase Inhibitors: 96-Week Results From the Japanese Subgroup Analysis of the ASCEMBL Study
Authors: Minami Yosuke , Doki Noriko , Matsuoka Hiroshi , Yokota Takafumi , Tomita Akihiro , Takahashi Naoto , Kubo Kohmei , Goto Tatsunori , Kirito Keita , Maki Akio , Aoki Makoto , Dawson Meryem Ktiouet , Matsumura Itaru 
Published: June 2024

AbstractAsciminib is a first-in-class BCR::ABL1 inhibitor that Specifically Targets the ABL1 Myristoyl Pocket (STAMP). It is approved worldwide and in Japan for chronic myeloid leukemia in chronic phase (CML-CP) with resistance or intolerance to previous tyrosine kinase inhibitor (TKI) therapy. In the Phase 3 ASCEMBL study, patients with CML-CP who received ≥ 2 prior ATP-competitive TKIs were randomized (2:1) to asciminib 40 mg twice-daily or bosutinib 500 mg once-daily. Here, we report the 96-week results of the subgroup analysis of Japanese patients (asciminib, n = 13; bosutinib, n = 3) in the ASCEMBL study. The MMR rate at Week 96 was 46.2% in asciminib-treated patients, increasing from Weeks 24 and 48. Patients who achieved MMR at Week 24 remained in MMR up to the Week 96 cutoff. While a high proportion of patients treated with asciminib remained on treatment at cutoff, none randomized to bosutinib were on treatment at Week 96. Despite the longer duration of exposure to asciminib, its safety and tolerability continued to be favorable with no new or worsening safety findings. Overall, the efficacy and safety outcomes in the Japanese subgroup were comparable with the ASCEMBL global study population, which supports the use of asciminib in Japanese patients with previously treated CML-CP.
Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
Authors: Starnovskaya Sofya S. , Nesterenko Liliana E. , Popov Roman S. , Kirichuk Natalya N. , Chausova Viktoria E. , Chingizova Ekaterina A. , Chingizov Artur R. , Isaeva Marina P. , Yurchenko Ekaterina A. , Yurchenko Anton N. 
Published: June 2024

AbstractThe marine holothurian-derived fungal strain KMM 4401 has been identified as Paragliomastix luzulae using 28S rDNA, ITS regions and the partial TEF1 gene sequences. The metabolite profile of the fungal culture was studied by UPLC-MS technique. The strain KMM 4401 is a source of various virescenoside-type isopimarane glycosides suggested as chemotaxonomic feature for this fungal species. Also Px. luzulae KMM 4401 was proposed as possible source of new bioactive secondary metabolites especially antimicrobials. Moreover, the co-cultures of Px. luzulae KMM 4401 with another marine fungus Penicillium hispanicum KMM 4689 inoculated simultaneously or after two weeks were investigated by same way. It was shown, that P. hispanicum KMM 4689 suppressed the production of most of Px. luzulae KMM 4401 metabolites. On the other hand, the co-cultivation of P. hispanicum KMM 4689 and Px. luzulae KMM 4401 resulted in increasing of production of main deoxyisoaustamide alkaloids of P. hispanicum KMM 4689 on 50–190%.
Graphical Abstract
Mapping the Apps: Ethical and Legal Issues with Crowdsourced Smartphone Data using mHealth Applications
Authors: Farag Nada , Noë Alycia , Patrinos Dimitri , Zawati Ma’n H. 
Published: June 2024

AbstractMore than 5 billion people in the world own a smartphone. More than half of these have been used to collect and process health-related data. As such, the existing volume of potentially exploitable health data is unprecedentedly large and growing rapidly. Mobile health applications (apps) on smartphones are some of the worst offenders and are increasingly being used for gathering and exchanging significant amounts of personal health data from the public. This data is often utilized for health research purposes and for algorithm training. While there are advantages to utilizing this data for expanding health knowledge, there are associated risks for the users of these apps, such as privacy concerns and the protection of their data. Consequently, gaining a deeper comprehension of how apps collect and crowdsource data is crucial. To explore how apps are crowdsourcing data and to identify potential ethical, legal, and social issues (ELSI), we conducted an examination of the Apple App Store and the Google Play Store in North America and Europe to identify apps that could potentially gather health data through crowdsourcing. Subsequently, we analyzed their privacy policies, terms of use, and other related documentation to gain insights into the utilization of users’ data and the possibility of repurposing it for research or algorithm training purposes. More specifically, we reviewed privacy policies to identify clauses pertaining to the following key categories: research, data sharing, privacy/confidentiality, commercialization, and return of findings. Based on the results of these app search, we developed an App Atlas that presents apps which crowdsource data for research or algorithm training. We identified 46 apps available in the European and Canadian markets that either openly crowdsource health data for research or algorithm training or retain the legal or technical capability to do so. This app search showed an overall lack of consistency and transparency in privacy policies that poses challenges to user comprehensibility, trust, and informed consent. A significant proportion of applications presented contradictions or exhibited considerable ambiguity. For instance, the vast majority of privacy policies in the App Atlas contain ambiguous or contradictory language regarding the sharing of users’ data with third parties. This raises a number of ethico-legal concerns which will require further academic and policy attention to ensure a balance between protecting individual interests and maximizing the scientific utility of crowdsourced data. This article represents a key first step in better understanding these concerns and bringing attention to this important issue.
Urban air mobility (UAM) and ground transportation integration: A survey
Authors: Yan Yiping , Wang Kai , Qu Xiaobo 
Published: June 2024

AbstractThis study explores urban air mobility (UAM) as a strategy for mitigating escalating traffic congestion in major urban areas as a consequence of a static transportation supply versus dynamic demand growth. It offers an in-depth overview of UAM development, highlighting its present state and the challenges of integration with established urban transport systems. Key areas of focus include the technological advancements and obstacles in electric vertical take-off and landing (eVTOL) aircrafts, which are essential for UAM operation in urban environments. Furthermore, it explores the infrastructure requirements for UAM, including vertiport deployment and the creation of adept air traffic control (ATC) systems. These developments must be integrated into the urban landscape without exacerbating land-use challenges. This paper also examines the regulatory framework for UAM, including existing aviation regulations and the necessity for novel policies specifically designed for urban aerial transport. This study presents a comprehensive perspective for various stakeholders, from policymakers to urban planners, highlighting the need for a thorough understanding of UAM’s potential and effective assimilation into urban mobility frameworks.