bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular‐Arc Bigraphs and Its Subclasses
Authors: Basu Asim , Das Sandip , Ghosh Shamik , Sen Malay 
Published: July 2012

AbstractIn this article, we obtain two new characterizations of circular‐arc bigraphs. One of them is the representation of a circular‐arc bigraph in terms of two two‐clique circular‐arc graphs while another one represents the same as a union of an interval bigraph and a Ferrers bigraph. Finally, we introduce the notions of proper and unit circular‐arc bigraphs, characterize them and show that, as in the case of circular‐arc graphs, unit circular‐arc bigraphs form a proper subclass of the class of proper circular‐arc bigraphs.
Physiological traits related to terminal drought resistance in common bean (Phaseolus vulgaris L.)
Authors: Rosales Miguel A , Cuellar‐Ortiz Sonia M , de la Paz Arrieta‐Montiel María , Acosta‐Gallegos Jorge , Covarrubias Alejandra A 
Published: July 2012

AbstractBACKGROUND: A major problem in common bean (Phaseolus vulgaris L.) agriculture is the low yield due to terminal drought. Because common beans are grown over a broad variety of environments, the study of drought‐resistant genotypes might be useful to identify distinctive or common mechanisms needed for survival and seed production under drought.RESULTS: In this study the relationship between terminal drought resistance and some physiological parameters was analysed using cultivars contrasting in their drought response from two different gene pools. Trials were performed in three environments. As expected, drought treatments induced a decrease in leaf relative humidity and an increase in leaf temperature; however, when these parameters were compared between susceptible and resistant cultivars under optimal irrigation and drought, no significant differences were detected. Similar results were obtained for chlorophyll content. In contrast, analysis of relative water content (RWC) and stomatal conductance values showed reproducible significant differences between susceptible and resistant cultivars grown under optimal irrigation and drought across the different environments.CONCLUSIONS: The data indicate that drought‐resistant cultivars maximise carbon uptake and limit water loss upon drought by increasing stomatal closure during the day and attaining a higher RWC during the night as compared with susceptible cultivars, suggesting a water balance fine control to achieve enough yield under drought. Copyright © 2012 Society of Chemical Industry
Physical barriers to carotenoid bioaccessibility. Ultrastructure survey of chromoplast and cell wall morphology in nine carotenoid‐containing fruits and vegetables
Authors: Jeffery Jennifer , Holzenburg Andreas , King Stephen 
Published: July 2012

AbstractBACKGROUND: The ultrastructural characterisation of cellular components is a key element in revealing the bases for differences in nutrient bioaccessibility among fruits and vegetables and their derived products. Together, cell walls and chromoplasts constitute the two major physical barriers to carotenoid release from the food matrix (structure) during digestion. In general, larger cells with thinner cell walls are most likely to fail under mechanical pressure. In relation to chromoplasts, the substructures plastoglobuli, crystals and membranes give decreasing rates of carotenoid solubilisation when exposed to digestive forces.RESULTS: This paper describes cell wall and chromoplast structures in nine carotenoid‐storing raw fruits and vegetables. Watermelon and melon cells were shown to have the largest cells concomitant with thin, non‐fibrous cell walls, while carrot, hypodermal grapefruit and sweet potato cells were smallest with fibrous or dense cell walls. Mango fruit showed the highest proportion of globules to other substructures. Carrot, papaya and tomato contained many crystalline structures. Finally, watermelon, mango and butternut squash developed a high proportion of membranous structures.CONCLUSION: A more precise description of the physical characteristics of foods that stand as barriers to bioaccessibility can help in understanding which are more or less inhibitory for particular foods. Copyright © 2012 Society of Chemical Industry
Proanthocyanidin‐rich grape seed extract reduces leg swelling in healthy women during prolonged sitting
Authors: Sano Atsushi , Tokutake Shoichi , Seo Akihiko 
Published: July 2012

AbstractBACKGROUND: Leg swelling is a modern‐day affliction of sedentary working women. The aim of this study was to evaluate the effectiveness of the intake of grape seed extract (GSE) on leg swelling in healthy Japanese women while sitting.RESULTS: Single intake trials and 14 day intake trials were held in a double‐blind, placebo‐controlled, crossover clinical study. A prolonged sedentary position was maintained for 6 h after GSE or placebo administration. Leg volume distension, increase in body extracellular fluid, and leg water were significantly suppressed in the GSE groups.CONCLUSION: The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting. © 2012 Society of Chemical Industry
Hepatic artery infusional chemotherapy in patients with unresectable colorectal liver metastases and extrahepatic disease
Authors: Ammori John B. , D'Angelica Michael I. , Fong Yuman , Cercek Andrea , Dematteo Ronald P. , Allen Peter J. , Kingham T. Peter , Paty Philip B. , Jarnagin William R. , Kemeny Nancy E. 
Published: July 2012

AbstractBackground and ObjectivesHepatic arterial infusional (HAI) chemotherapy combined with systemic chemotherapy is effective palliative therapy for unresectable colorectal cancer liver metastases (CRLM). Some patients considered for HAI have evidence of minimal extrahepatic disease (EHD), and the role of HAI in these situations is unknown.MethodsAll patients with unresectable CRLM treated with HAI and systemic chemotherapy from 2000 to 2009 were included. Survival of patients who were ultimately proven to have low‐volume EHD was compared to those without EHD.ResultsThree hundred seventy‐three patients were included in this study. Seventy‐nine percent of patients were previously treated with chemotherapy. One hundred forty‐five patients (39%) ultimately proved to have EHD. Median overall survival from HAI pump placement in patients without EHD was 32 months compared to 16 months for patients with EHD, P < 0.001. Median overall survival from HAI pump placement in patients with a single site of EHD was 18 months compared to 9 months for those with multiple sites of EHD, P = 0.01.ConclusionsIn this study of heavily pre‐treated patients, overall survival was favorable in patients who proved to have EHD at one site. J. Surg. Oncol. 2012; 106: 953–958. © 2012 Wiley Periodicals, Inc.
Direct dynamics study of the hydrogen abstraction reaction of CF3CH2Cl + Cl → CF3CHCl + HCl
Authors: Zhao Yuan , He Hongqing , Zhang Jinglai , Wang Li 
Published: July 2012

AbstractThe hydrogen abstraction reaction of Cl atoms with CF3CH2Cl (HCFC‐133a) is investigated by using density function theory and ab initio approach, and the rate constants are calculated by using the dual‐level direct dynamics method. Optimized geometries and frequencies of reactants, transition state, and products are computed at the B3LYP/6‐311+G(2d,2p) level. To refine the energetic information along the minimum energy path, single‐point energy calculations are carried out at the G3(MP2) level of theory. The interpolated single‐point energy method is employed to correct the energy profiles for the title reaction. The rate constants are evaluated by using the canonical variational transition state theory with a small‐curvature tunneling correction over a wide range of temperature, 200–2000 K. The variational effect for the reaction is moderate at low temperatures and very small at high temperatures. However, the tunneling correction has an important contribution in the lower temperature range. The agreement between calculated rate constants and available experimental values is good at lower temperatures but diverges significantly at higher temperatures. © 2012 Wiley Periodicals, Inc. Int J Chem Kinet 44: 661–667, 2012
Transoral robotic surgery: A multicenter study to assess feasibility, safety, and surgical margins
Authors: Weinstein Gregory S. , O'Malley Bert W. , Magnuson J. Scott , Carroll William R. , Olsen Kerry D. , Daio Lixia , Moore Eric J. , Holsinger F. Christopher 
Published: July 2012

AbstractObjectives/Hypothesis:Our objective was to determine the safety, feasibility, and the adequacy of surgical margins for transoral robotic surgery (TORS), by reviewing the early results from independent institutional review board‐approved clinical trials in three separate institutions.Study Design:Pooled Data from Independent Prospective Clinical Trials.Methods:One hundred ninety‐two patients were initially screened, but inadequate exposure did not permit TORS in 13 (6.7%). For two additional patients, TORS was begun but intraoperatively converted to an open procedure. Thus, the intent‐to‐treat population was 177 patients (average age, 59 years; 81% male), predominantly comprised of tumors arising in the oropharynx (139, 78%) and larynx (26, 15%). TORS was performed for 161 (91%) patients with malignant disease: 153 (95%) with squamous cell carcinoma (T1 [50, 32.7%], T2 [74, 48.4%], T3 [21, 13.7%], T4 [8, 5.2%]), six patients (3.72%) with salivary gland tumors, and two patients with carcinoma in situ. The average follow‐up was 345 days.Results:There was no intraoperative mortality or death in the immediate postoperative period. Average estimated blood loss was 83 mL; no patient required transfusion. The rate of positive margins was 4.3%. Twenty‐nine patients (16%) experienced 34 serious adverse events that required hospitalization or intervention (grade 3) or were considered life threatening (grade 4, 2.3%). Tracheostomy was performed in 12.4% of all patients (22/177), but only 2.3% had a tracheostomy at last follow‐up. For all patients undergoing TORS without previous therapy, the percutaneous endoscopic gastrostomy dependency rate was 5.0%. The average hospital stay was 4.2 days.Conclusions:Based on this multicenter study, TORS appears to be safe, feasible, and as such play an important role in the multidisciplinary management of head and neck cancer.
Systematic analysis of cephalometry in obstructive sleep apnea in Asian children
Authors: Ping‐Ying Chiang Rayleigh , Lin Chia‐Mo , Powell Nelson , Chiang Yuh‐Chyun , Tsai Yih‐Jeng 
Published: July 2012

AbstractObjectives/Hypothesis:This study was designed to systematically analyze the relationship between a cephalometric analysis and the apnea‐hypopnea index in a group of Asian children with obstructive sleep apnea.Study Design:Retrospective study.Methods:Data were collected from 56 children with obstructive sleep apnea who were between 3 and 13 years old. Each child underwent attended overnight polysomnography and cephalometry. We measured nine angles, 10 lines, and two ratios as well as adenoid size on each cephalometric film. Data included five segments of the upper airway: nasal cavity (segment 1), nasopharyngeal space (segment 2), retropalatal space (segment 3), retroglossal space and hyoid (segment 4), and oral cavity‐related space (segment 5).Results:Four cephalometric anthropomorphic findings (Gn‐Go‐H, MP‐H, MPH/GnGo, Ad/Na) were related to the apnea‐hypopnea index. Three of the four parameters belonged to segment 4, indicating the importance of hyoid position in pediatric obstructive sleep apnea.Conclusions:This study showed that segment 4 was the most important segment affecting the apnea‐hypopnea index. Most of the cephalometric parameters in segment 4 did not show a difference from the results of Caucasian groups, except that mandibular length and position appeared to have more positive findings in the Caucasian results. In segment 2, the apnea‐hypopnea index was less affected by the skull base‐related parameters in our data. The reason why the other segments appeared to play a lesser role in pediatric obstructive sleep apnea might due to the limitations of two‐dimensional imaging. Further cephalometric studies with anterior‐posterior view and on the differences between Caucasian and Asian children are mandatory.
Customization of the voice prosthesis to prevent leakage from the enlarged tracheoesophageal puncture: Results of a prospective trial
Authors: Lewin Jan S. , Hutcheson Katherine A. , Barringer Denise A. , Croegaert Lindsay E. , Lisec Asher , Chambers Mark S. 
Published: July 2012

AbstractObjectives/Hypothesis:Customization of the tracheoesophageal (TE) voice prosthesis (VP) is often preferred over surgical closure to prevent aspiration around the VP in laryngectomized patients with an enlarged tracheoesophageal puncture (TEP), but it has not been thoroughly evaluated.Study Design:Single‐institution prospective trial.Methods:A prospective trial was conducted to evaluate the effectiveness of a customized VP with the addition of an enlarged tracheal and/or esophageal collar in patients with leakage around an enlarged TEP. Absence of leakage around the VP after placement defined immediate effectiveness. Long‐term success was defined by the prevention of adverse events related to leakage during the study period. Events that defined failure included: permanent gastrostomy dependence, aspiration pneumonia, and/or surgical TEP closure.Results:Twenty‐one patients with enlarged TEP were enrolled (2003–2006). Insertion of a customized VP was unsuccessful in one patient; 145 customizations were performed in the remaining 20 patients (median, 3.5 customizations) during the trial period. Of the customizations, 77% (112/145) prevented leakage immediately after VP insertion. The most common adverse event was dislodgement of the prosthesis (11%) or the collar alone (7%) in 18% (26/145) of customized VP placements. Six patients who died of disease were not evaluable for long‐term outcomes. Long‐term success was achieved in 80% (12/15) of evaluable patients who avoided permanent gastrostomy, aspiration pneumonia, and surgical TEP closure.Conclusions:Prosthetic customization offers an effective method to prevent leakage around the VP in many patients with an enlarged TEP, thereby preserving TE voice while avoiding surgical closure in this high‐risk population.
Sentinel node biopsy in early oral squamous cell carcinomas: A 10‐year experience
Authors: Melkane Antoine E. , Mamelle Gérard , Wycisk Gregory , Temam Stéphane , Janot François , Casiraghi Odile , Lumbroso Jean 
Published: July 2012

AbstractObjectives/Hypothesis:To evaluate the reliability of the sentinel node (SN) biopsy in early oral squamous cell carcinomas.Study Design:Prospective cohort study.Methods:We conducted a primary prospective study on 53 consecutive patients presenting T1, T2 N0 squamous cell carcinomas of the oral cavity between January 2000 and June 2003. Primary results demonstrated a negative predictive value of 100%. The series was then extended until June 2010, with a total number of 166 successful procedures.Results:The cohort accounted for 118 males and 48 females with a mean age of 56 years. The median follow‐up period was 36 months. There were 42 patients (25%) with positive SNs, 14 of them (33%) only harboring micrometastasis. The negative predictive value of the sentinel node biopsy was 95.2%. The SN involvement was strongly correlated with the tumor location (34% of SN+ for the tongue vs. 13% for the floor of mouth, P = .003), tumor stage (18% of SN+ for T1 vs. 40% for T2, P = .002), depth of invasion (median depth for SN+ lesions was 6.5 mm vs. 4 mm for SN− lesions, P = .028), and lymphovascular involvement (P = .002). The false‐negative rate of frozen section examination was 42%.Conclusions:The sentinel node biopsy appears to be an excellent staging method in early oral cancers. This study also provides evidence that routinely undiagnosed micrometastasis may have clinical significance.
Paranasal sinus exostoses: An unusual complication of topical drug delivery using cold nasal irrigations
Authors: Haffey Timothy , Woodard Troy , Sindwani Raj 
Published: July 2012

AbstractObjectives/Hypothesis:The use of topical drug delivery through nasal irrigations can minimize systemic side effects and deliver higher concentrations of drugs directly to diseased sinus mucosa. Complications related to this popular method of treatment are not well described. We present our experience with paranasal sinus exostosis (PSE), a new diagnostic entity that appears to be a complication of cold nasal irrigations.Study Design:Retrospective chart review.Methods:Retrospective chart reviews were performed on patients within the Cleveland Clinic Foundation from 2005 to 2011. Six patients were identified with sinus exostoses. A literature review for “sinonasal exostoses” and “paranasal sinus exostoses” was performed using PubMed.Results:Six patients with PSE were identified at the Cleveland Clinic Foundation between 2005 and 2011. All patients had undergone sinus surgery, and none had documented evidence of PSE prior to surgery. There was no evidence of worsening PSE once the cold irrigations were stopped. No patients showed any resolution of PSE over time. None of our patients has progressed to have disease burden significant enough to require intervention.Conclusions:PSE is a rare condition that mirrors a well‐described otologic process; exostoses of the external auditory canal. PSE appears to be a complication of cold nasal irrigations. It does not resolve with the halting of cold irrigations, but does not appear to progress further after intervention. PSE only affects postoperative patients. With the evolving trend to treat postoperative sinus disease topically, the clinician should be aware of the dangers of cold irrigations, and patients should be counseled accordingly.
Extracapsular dissection for benign parotid tumors: A meta‐analysis
Authors: Albergotti W. Greer , Nguyen Shaun A. , Zenk Johannes , Gillespie M. Boyd 
Published: July 2012

AbstractObjectives/Hypothesis:Recent studies suggest that extracapsular dissection (ECD) is an option for the resection of certain benign parotid tumors. This study investigates complication rates and effectiveness of ECD versus superficial parotidectomy (SP) for the treatment of primary benign parotid neoplasms.Study Design:Systematic literature review with meta‐analysis.Methods:Studies available for inclusion evaluated the complications and effectiveness of ECD and SP as surgical techniques for the treatment of solitary, benign parotid tumors. An Ovid/Medline search revealed nine articles that met inclusion criteria. A critical review and meta‐analysis of these articles was performed.Results:The included studies evaluated a total of 1,882 patients. There was no observed difference in tumor recurrence between the ECD and SP groups (odds ratio [OR], 0.557; 95% confidence interval [CI], 0.271‐1.147). There was a significantly lower rate of transient facial nerve paresis (OR, 0.256; 95% CI, 0.174‐0.377) in the ECD group (59 of 741; 8.0%) compared to the SP group (81 of 397; 20.4%); however, there was no observed difference in permanent facial paralysis between the ECD and SP groups (OR, 0.878; 95% CI, 0.282‐2.730). Frey's syndrome was less often observed (OR, 0.117; 95% CI, 0.071‐0.191) after ECD (27 of 602; 4.5%) compared to SP (75 of 287; 26.1%).Conclusions:This systematic review with meta‐analysis suggests that ECD has a similar recurrence rate as SP with fewer postoperative complications. ECD may be considered an alternative surgical modality for select benign parotid neoplasms.
Hearing aid satisfaction and use in the advanced digital era
Authors: Kaplan‐Neeman Ricky , Muchnik Chava , Hildesheimer Minka , Henkin Yael 
Published: July 2012

AbstractObjectives/Hypothesis:To evaluate satisfaction ratings and use patterns of advanced digital hearing aids (HAs) in a group of hearing‐impaired adults by means of self‐report questionnaires.Study Design:A self report questionnaire study.Methods:One hundred seventy‐seven hearing‐impaired adults who were fitted with advanced digital HAs at the Speech and Hearing Center at Sheba Medical Center were asked to participate in a structured telephone interview regarding HA satisfaction and use by means of the Satisfaction With Amplification in Daily Life (SADL) questionnaire. Patients who were not using their HAs completed a nonuse questionnaire.Results:One hundred thirty‐one patients participated in the survey, yielding a response rate of 74%. Eighty‐three percent used their HAs regularly, whereas 17% were nonusers. Of the users, 92% were satisfied to some degree with their HAs. The global SADL score was 5.12 on a scale of 1 to 7. Background variables that were significantly associated with satisfaction ratings were hours of HA use per day, fitting mode (binaural vs. monaural), age, and degree of hearing loss. Although nonuse was not significantly associated with background variables, the main reasons for nonuse were excessive amplification in background noise and minimal functional benefit.Conclusions:High satisfaction and use rates were characteristic of adults fitted with advanced digital HAs. Patients should be advised that longer use of HAs per day may lead to higher satisfaction and that binaural amplification is advantageous, especially while communicating in noise. Finally, expectation from HA functionality in challenging listening situations should be realistic, as additional research and technology development is still needed.
Occult middle ear and mastoid fluid in acute otitis externa
Authors: Brennan Tara E. , Saadia‐Redleaf Miriam I. 
Published: July 2012

AbstractObjectives/Hypothesis:Presence of fluid in the middle ear (ME) or mastoid air cells in acute otitis externa (OE) has not been reported. We hypothesize that in patients with OE there is often otitis media (occult middle ear and mastoid fluid) and secondary fluid in the mastoid air cell system, which is not seen during a clinical examination because of edema in the external canal skin.Study Design:Retrospective chart review.Methods:We reviewed the medical records of 209 patients who presented to our ear, nose, and throat (ENT) clinic with acute OE that was resolved with oral and/or topical antibiotics.Results:Twenty‐seven of the 209 patients presented with unilateral or bilateral acute OE (29 ears) and received a computed tomography (CT) scan of their temporal bones, which was ordered by the Emergency Department or ENT services. Twenty‐three of 29 ears (79%) showed fluid in the ME, mastoid, or both. Nine of the 10 patients (82%), who obtained their CT scan within 1 week of symptom onset, were found to have fluid.Conclusions:These findings support our hypothesis and serve to inform the medical community (both ENT and primary care) that fluid is often present in the ME or mastoid in patients with acute OE whose symptoms will resolve with oral and/or topical antibiotics.