bluuebunny/crossref_metadata_2025_split huggingface dataset:
The mechanism of recrystallization of binary aluminum and tin bronzes
Authors: Marukovich E. I. , Stetsenko V. Yu. , Stetsenko A. V. 
Published: June 2024

A nanostructural mechanism for recrystallization of binary aluminum and tin bronzes has been developed. First, structure-forming nanocrystals of α-phases, β-phases and γ-phases are formed from elementary nanocrystals of copper, aluminum, tin and their free atoms. The crystallization centers of microcrystals of phases are formed from them. From these centers, structure-forming nanocrystals of phases, free atoms of copper, aluminum, tin, microcrystals of α-phases, β-phases and γ-phases of binary aluminum and tin bronzes are formed.
A phase 3 randomised double-blind placebo-controlled trial of mirtazapine as a pharmacotherapy for methamphetamine use disorder: A study protocol for the Tina Trial
Authors: McKetin Rebecca , Degan Tayla , Saunders Lucy , Nguyen Long , Dore Gregory , Shoptaw Steven , Farrell Michael , Degenhardt Louisa , Kelly Peter J , Turner Alyna , Clare Philip J , Dean Olivia M , Arunogiri Shalini , Colledge-Frisby Samantha , Koeijers Juanita , Goodman-Meza David , Sinclair Barbara , Reid David , Hill Harry , Hayllar Jeremy , Christmass Michael , Cordaro Frank , Lundin Robert , Liaw Willy , Liu Danica , Holyoak Ellie , Wu Brian Tid-Fung , Kegan Joel , Kontogiannis Ava , Palmer Lily , Morrison Caity , Wrobel Anna , Hyland Rebecca , Byrne Marianne , Zahra Emma , Russell Samantha , Berk Michael 
Published: June 2024

Abstract

Background
There are no approved pharmacotherapies for methamphetamine use disorder. Two preliminary phase 2 randomised controlled trials have found mirtazapine, a tetracyclic antidepressant, to be effective in reducing methamphetamine use. The proposed Tina Trial is the first phase 3 placebo controlled randomised trial to examine the effectiveness and safety of mirtazapine as an outpatient pharmacotherapy for methamphetamine use disorder.
Methods
This is a multi-site phase 3 randomised, double-blind, placebo-controlled parallel trial. Participants are randomly allocated (1:1) to receive either mirtazapine (30 mg/day for 12 weeks) or matched placebo, delivered as a take-home medication. The target population is 340 people aged 18–65 years who have moderate to severe methamphetamine use disorder. The trial is being conducted through outpatient alcohol and other drug treatment clinics in Australia. The primary outcome is measured as self-reported days of methamphetamine use in the past 4 weeks at week 12. Secondary outcomes are methamphetamine negative oral fluid samples, depressive symptoms, sleep quality, HIV risk behaviour and quality of life. Other outcomes include safety (adverse events), tolerability, and health service use. Medication adherence is being monitored using MEMS® Smart Caps fitted to medication bottles.
Discussion
This trial will provide information on the safety and effectiveness of mirtazapine as a pharmacotherapy for methamphetamine use disorder when delivered as an outpatient medication in routine clinical practice. If found to be safe and effective, this trial will support an application for methamphetamine use disorder to be included as a therapeutic indication for the prescription of mirtazapine.
Trial Registration:
Australian and New Zealand Clinical Trials Registry (ACTRN12622000235707). Registered on February 9, 2022.
Ceftazidime-Avibactam Use in Carbapenem-resistant Klebsiella pneumoniae Bloodstream Infections: A Retrospective Observational Multicenter Study in OXA-48 Endemic settings
Authors: Mert Ali , Derin Okan , Akalın Halis , Dumlu Rıdvan , Gündeş Sibel , Zengin Rehile , Kocagöz Sesin , Gündoğdu Yasemin , Köksal İftihar , Yalçın Demet , Üstün Cemal , Kapmaz Mahir , Görenek Levent , Karahangil Kadriye , Can Füsun , Ergönül Önder , Concortia Concortia 
Published: June 2024

Abstract

Background.
Experience of ceftazidime-avibactam (CAZ-AVI) use in OXA-48 producing K. pneumoniae bloodstream infections (OXA-48-Kp BSIs) is limited. We aimed to describe the clinical outcomes of OXA-48-Kp BSIs treated with CAZ-AVI in hospital settings, where OXA-48-producing K. pneumoniae is endemic.
Methods.
A multicenter retrospective observational study was conducted between January 2017 and September 2021. The aim of the study is to describe the clinical data that affects outcome, the 30-day mortality and relapse. The predictors of 30-day mortality are detected by using cox regression model.
Results.
We included 106 adults with CAZ-AVI-susceptible, carbapenem-resistant K. pneumoniae (CR-Kp) BSIs who received at least 72 hours of CAZ-AVI therapy. Mortality was found to be lower in those who started CAZ-AVI from the initial treatment compared to those who switched from colistin-based-regimen to CAZ-AVI[14.3% (n = 3/21) vs 37.7%(n = 32/85), p = 0.04].In multivariate analysis older age, having severe neutropenia were found to be significantly associated with the higher rate of mortality. Same-day CAZ-AVI start lowers mortality risk significantly.(HR:0.25, CI: 0.07–0.84, p = 0.025).
Conclusions.
Data of our cohort showed that CAZ-AVI monotherapy is an important treatment option in OXA-48-Kp BSIs. In addition, the study confirmed that early initiation of CAZ-AVI is more appropriate than switch to CAZ-AVI from a colistin-based-regimen.
Assessment of Heavy Metal Contamination in Offshore and Inshore Sediments of The Arabian Gulf
Authors: Alharbi Khaild N. , Almalki Majed A. , Almotairy Hany M. , Alotaibi Mohammed F. , Alharbi Khaled S. , Alqahtani Sarah H. , Aleid Musaad K. , Alfaifi Hassan Y. , Almoiqli Mohammed S. , Alhadadi Abdulrahman H. , Bin-Suliman Asim , Albaiji Ahmed , Alhafedh Yousef , Alnasser Ibrahim , Albarqi Mubarak M. , Alsulami Raed A. , Abo-Alhannod Omar , Alzahrani Ekab S. 
Published: June 2024

Abstract

The study focuses on evaluating the presence of heavy metals in sediments samples from the Arabian Gulf, collected in December 2023. Utilizing inductively Coupled Plasma Mass Spectrometry (ICP-MS, the concentrations of various heavy metals were determined. Notably, the average concentration of iron (Fe) exceeds 5000 mg/kg. Other metals such as chromium (Cr), cobalt (Co), nickel (Ni), copper (Cu), and zinc (Zn) exhibit concentrations within acceptable limits. However, arsenic (As) concentration averages around 22 mg/kg. Moreover, concentrations of silver (Ag) and cadmium (Cd) slightly exceed the recommended levels.
Factors Influencing the Improvement of Environmental Health Literacy in Shanghai Residents: Three Rounds of Cross-sectional Studies from 2020 to 2022
Authors: Han Fengchan , Tong Ling , Qian Hailei , Shi Yewen , Zhang Jiang hua , Dong Chunyang , Wang Duo , Chen Feier , Wu Chen , Xu Mingjing , Liu Yongping , Su Jin , Xu Huihui , He Yi , Chen Tian , Shaofeng Sui 
Published: June 2024

Abstract

Background
In 2019, the Chinese State Council issued the "Healthy China Initiative (2019–2030)", in which the section of " Action for the promotion of a Healthy Environment " explicitly calls for the levels of environmental and health literacy (EHL) of the residents to reach more than 15% and 25% in 2022 and 2030, respectively.
Objective
In order to identify weaknesses in the popularization of environmental health knowledge and make targeted improvements, Shanghai has conducted three rounds of environmental health literacy (EHL) surveys from 2020 to 2022.
Methods
Multi-stage random sampling method was used in the three rounds of cross-sectional studies. A total of 8348 valid participants aged from 15 to 69 were assessed by The Core Questionnaire for Assessing the EHL of Chinese residents (Trial Implementation). Factors influencing EHL levels were analyzed using χ 2-test, Kruskal-Wallis test, generalized linear model (GLM), and multivariate logistic regression.
Results
The mean score of EHL for all participants was (58.93 ± 16.35) points, which was below the reference value of 70 points. Compared with the first round of the survey in 2020 (55.28 ± 15.64 points), the scores were significantly promoted (P < 0.001) in 2021 and 2022, with (61.77 ± 15.92 points) and (62.13 ± 17.14 points), respectively. The results showed that the EHL significantly increased from 18.74% in 2020 to 33.22% in 2022. The generalized linear model suggested that survey year, residential area, education level, occupation and income were also influential factors of EHL. For educational attainment, the largest increase of 11.937 points was observed in the postgraduate and above group compared with the control group (primary school and below). The results of the multivariate logistic regression model were consistent with those of GLM: residents had higher EHL in the groups of third round survey [OR: 2.71, 95%CI: 2.23–3.13], high education [OR: 3.73, 95%CI: 2.40–5.86], high income [OR: 1.61, 95%CI: 1.26–2.06], and student occupation [OR: 3.09, 95%CI: 2.06–4.65].
Conclusions
Education attainment was a crucial factor influencing the EHL of Shanghai residents. The popularization and promotion of environmental health knowledge can significantly improve the EHL of Shanghai residents.
Durable All Inorganic Perovskite Tandem Photovoltaics
Authors: Yan Keyou , Duan Chenghao , Zhang Kaicheng , Peng Zijian , Li Shiang , Zou Feilin , Wang Feng , Li Jiong , Zhang Zheng , Chen Chang , Zhu Qiliang , Qiu Jianhang , Lu Xinhui , Li Ning , Ding Liming , Brabec Christoph , Gao Feng 
Published: June 2024

Abstract

Inorganic perovskite tandem solar cells (IPTSCs) are promising candidates to break the efficiency bottleneck and address the stability issue. However, challenges remain in fabricating 2-terminal (2T) IPTSCs due to the inferior film formation and deep trap states induced by tin cations. Herein, a green ligand evolution (GLE) strategy with p-toluenesulfonyl hydrazide is employed to regulate film formation and eliminate deep traps in inorganic narrow bandgap perovskite, enabling the successful development of 2T IPTSCs. Accordingly, the 1.31 eV CsPb0.4Sn0.6I3:GLE device delivers a record efficiency of 17.41%. Combined with the 1.92 eV CsPbI2Br top-cell, 2T-IPTSCs exhibit a champion efficiency of 22.57% (certified 21.92%). Additionally, IPTSCs are engineered to deliver remarkable operation durability under maximum power point tracking, maintaining 80% of the initial efficiency at 65 ℃ for 1510 h and 85℃ for 800 h, respectively.
Serum metabolite changes are implicated in high-altitude acclimatization and de-acclimatization
Authors: Wei Wenxiang , Liu Xiaoyan , Yang Wei , Li Qiuli , Cai Mingjing , Dai Wenjing , Zhang Haifeng , Xing Wenjuan , Ma Lijie 
Published: June 2024

Abstract

For individuals from lowland areas traveling to high-altitude regions, acclimatization and de-acclimatization (ADA) to high altitudes is an inevitable physiological process, accompanied by complex metabolic adjustments. In this study, we investigated 18 subjects (nine males and nine females) who traveled to and remained at an altitude of 4200 m for 3 months. We used untargeted metabolomics to analyze serum metabolomic changes after this period and then at specific time points after their return to the plains. We observed considerable differential serum metabolite expression at T1 (after the 3 month-high-altitude stay), T2 (day 2 after returning to the plains), and T3 (day 30 after returning to the plains). Gender differences and initial high-altitude response levels also affected metabolite changes. Metabolite-related signaling pathway analyses showed that the most significant differential metabolic pathways at T1 and T2 were pentose phosphate pathway (PPP), butanoate metabolism, arginine biosynthesis, and glucagon signaling pathways. The most significant differential metabolic pathways at T1 and T3 were galactose metabolism, arginine biosynthesis, sphingolipid signaling pathway, ATP-binding cassette (ABC) transporter, and biosynthesis of unsaturated fatty acid (FA) pathways. The most significant differential metabolic pathways between males and females at T1 were ABC transporter, purine metabolism (PM), central carbon metabolism in cancer (CCMiC), ascorbate and aldarate metabolism (AAM), and valine, leucine, and isoleucine biosynthesis pathways. Thus, during ADA to high altitudes, ABC transporter, PP, pentose and glucuronate interconversion (PGI), and PM signaling pathways had important roles. Our data provide new insights into the metabolic changes during ADA to high altitudes.
Is Tanzania Freewill Prevention A Response Enough? Reflecting Market Vendors Adherence to Covid-19 Infection Prevention Control Measures in Morogoro Municipal
Authors: Ndeki Douglas G. , Anaseli Mackfallen 
Published: June 2024

Abstract

BACKGROUND
The purpose of this evaluation study was to assess the status of adherence of IPC measures among market vendors in Morogoro Municipal. Specifically, the study aimed to examine IPC measure implemented, the proportion of market vendors’ adherence to IPC measures, factors influencing adherence of IPC among market vendors and perception of market vendors on COVID-19 prevention measures.
METHODS
We employed a cross- sectional study to 525 respondents, where 524 were market vendors and 1 respondent was from Morogoro Municipal Health authority. We deployed sequential mixed methods to the study including questionnaires (quantitative), interviews and unstructured observations (qualitative). We used descriptive statistics to summarize socio - demographic characteristics and Multivariate Logistic regression model to analyze factors influencing adherence of COVID-19.
RESULTS
81.1% of market vendors adhere to IPC measure. However, there were difference in adherence across groups by education 43%. Hand hygiene was the common practiced IPC measure (60.1%), whereas the least practiced measure was mask wearing (10.5%). Age, education level, residence, knowledge on isolation period and previous experience with someone with COVID-19 had influence to adherence of COVID-19 prevention measures by significance value (P < 0.05).
CONCLUSION
Adherence status of market vendors to COVID-19 IPC measures is satisfying. The study recommends improved behavioral change measures such as education in rural areas as it was in urban areas and an increased budget on emergency preparedness.
Identification and validation of disulfidptosis-related signature to evaluate clinical outcomes, immune infiltration and drug sensitivity in osteosarcoma
Authors: Zhao Yonghui , Su Xiaochen , Teng Menghao , Ru Hao , lu Ziliang , Zhang Yulong , Zhang Yilei , Zhang Yingang 
Published: June 2024

Abstract

Disulfidptosis is a novel form of programmed cell death discovered by Liu et al. It's initiated in cells highly expressing SLC7A11, especially in cancers. Our principal aim is to establish and validate a prognostic prediction model for osteosarcoma patients, potentially providing a fresh perspective on the characteristics of disulfidptosis in osteosarcoma and its treatment. Osteosarcoma cohorts obtained from the TARGET and GEO databases were classified into disulfidptosis-high/low-related groups to analyze the Differentially Expressed Genes (DEGs) using the ssGSEA method. DEGs were subsequently analyzed by the Weighted Gene Co-expression Network Analysis (WGCNA) method. Various machine learning algorithms, including the log-rank test, univariate Cox analysis, and LASSO algorithm, were employed, yielding 5 Disulfidptosis-Related Genes (DRGs). GSVA and ssGSEA, were also conducted to investigate the underlying mechanisms of disulfidptosis in osteosarcoma. We established a reliable disulfidptosis-related classification, aand our subsequent analysis has suggested intriguing disparities in the expression of the pentose phosphate pathway (PPP) and cytoskeleton regulation among the groups, indicating that the high-related group was more susceptible to disulfidptosis. 5 disulfidptosis-related genes were selected from the differentially expressed genes (DEGs) , and samples in the cohorts were divided into high-/low-risk groups based on the risk score. Functional analysis demonstrated significantly higher expression of the regulation of the cytoskeleton pathway in the high-risk group. Additionally, immune cell-associated pathways such as the T cell receptor signaling pathway and NOD/TOLL-like receptor signaling pathway showed significant decreases in the high-risk group. We then analyzed the infiltration of immune cells in the tumor microenvironment, revealing lower infiltration of almost every immune cell in the high-risk group. To gain insights into the clinical treatment of osteosarcoma patients, we also analyzed the differences in drug sensitivity between the risk groups, identifying 8 drugs that were more sensitive in the high-risk group.
Anomalous systemic artery supply to the left basal lung with arterial dissection of the feeding artery: a case report and literature review
Authors: Ma Luping , Xia Ruiming , Yu Zhongqiang , Wang Liang , Hu Wenbin , Yao Kelin 
Published: June 2024

Abstract

Anomalous systemic arterial supply to the left basal lung is a rare congenital abnormality and is even rarer when associated with arterial dissection of the feeding artery. Herein, we report a young patient who was hospitalized with sudden chest pain, which proved to be an abnormal thoracic aorta supplying blood to the basal segment of the left inferior lobe of the lung, with the supply artery dissection. It hasn't been reported as far as we know. The patient was successfully surgically resected and recovered well at follow-up.
Impact of Desmopressin on Clinical Outcomes in Patients with Spontaneous Antiplatelet-Associated Intracerebral Hemorrhage Undergoing Neurosurgical Intervention: An Observational Multi-Center Study
Authors: Hsu Pang-Ting , Shuo-Chi Chien , Chen Ching-Chang , Liu Zhuo-Hao , Chuang Chi-Cheng , Tsai Yu-Chen , Chaou Chung-Hsien , Yen Chieh-Ching 
Published: June 2024

Abstract

Objective:
Managing surgical cases of acute spontaneous intracerebral hemorrhage (ICH) in patients with antiplatelet therapy presents significant challenges due to the heightened risk of bleeding. Desmopressin acetate (DDAVP) is commonly employed as a management strategy. This multi-center study aims to compare the functional and safety outcomes in patients with or without preoperative DDAVP administration after spontaneous antiplatelet-associated ICH.
Methods:
From January 2016 to November 2023, we enrolled patients with spontaneous ICH who were under antiplatelet therapy and needed neurosurgical interventions in the emergency departments. Patients were excluded for traumatic brain injury, ICH from subarachnoid hemorrhage, arteriovenous malformation, intracranial tumors, coagulopathies, and anticoagulant use. The primary outcome was the modified Rankin Scale (mRS) at discharge. Secondary endpoints included safety outcomes, in-hospital and follow-up outcomes.
Results:
A total of 75 patients were included, comprising 26 patients treated with DDAVP and 49 patients in the control group. After inverse probability of treatment weighting adjustment, there were no significant differences in baseline characteristics except for preoperative platelet transfusion between the DDAVP and control group (73.6% vs 33.6%; p = 0.007). There were no significant differences in mRS of 4 – 6 at discharge between groups (77.4% vs 85.1%; p = 0.533). Multivariable generalized estimating equations logistic regression demonstrated DDAVP was not significantly associated with improved functional outcome, safety outcomes, in-hospital or follow-up outcomes.
Conclusion:
This study demonstrated that there was no significant difference in mRS at discharge or SAEs between patients with and without DDAVP administration. Further randomized controlled trials are warranted to validate our findings.
Influencing factors of work engagement among ophthalmic specialized nurses in China: a cross-sectional study
Authors: Ren Jie , Zhang Xin , Gao Yun-Xia 
Published: June 2024

Abstract

Aim: This study aims to investigate the current status of work engagement among ophthalmic specialized nurses in China and explore the multifaceted factors influencing work engagement from the physical, psychological, and social perspectives.
Methods：This study adopts a cross-sectional survey design, distributed electronic questionnaires through WeChat software, and 261 valid questionnaires were received from ophthalmic specialized nurses. The survey includes demographic information about ophthalmic specialized nurses, as well as work engagement, sleep quality and social support. A generalized linear model was used to investigate the factors influencing the work engagement of ophthalmic specialized nurses.
Results: The overall work engagement score among ophthalmic specialized nurses in our study was 143.70±13.66. Multivariate analysis showed that participation in teaching, professional title, sleep quality and perceived social support were the influencing factors of work engagement of ophthalmic specialized nurses.
Conclusion: Ophthalmic specialist nurses in China demonstrate a relatively high level of work engagement. Those with the title of senior nurse, involvement in teaching, better sleep quality, and higher perceived social support exhibit higher work engagement.
Impact of caudate lobe resection on overall survival and liver disease-free survival in colorectal liver metastases: A pilot study
Authors: Gul Melih Can , Demirel Emin 
Published: June 2024

Abstract

BACKGROUND
This study aimed to evaluate the management of colorectal liver metastases (CRLM) and the role of anatomical resections, with particular reference to the caudate lobe.
METHODS
We obtained all patient data from the Preoperative CT and Survival Data for Patients Undergoing Resection of Colorectal Liver Metastases dataset. Patients who underwent total caudate lobe resection without radiological evidence of metastases were analyzed. To investigate the net effect of caudate lobe resection, propensity score matching (PSM) was applied to most other parameters. The Kaplan-Meier and log-rank tests were used to calculate overall survival (OS) and liver disease-free survival (liver-DFS) and to investigate differences between groups.
RESULTS
Patients who underwent total caudate resection had better results in terms of overall survival in the whole data set and after PSM (respectively, p < 0.001 HR: 0.43, 95%CI:0.26–0.72 p:0.024, HR: 0.65 95%CI:0.59–0.79).Patients who underwent total caudate resection had better results in terms of liver-DFS in the whole data set set and after PSM (respectively, p = 0.014, HR = 0.46, 95%CI: 0.24–0.85, p = 0.026 HR = 0.5, 95%CI: 0.37–0.79)
CONCLUSİONS
We believe that the addition of total caudate lobe resection to resection may contribute to both OS and liver DFS.