bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen‐Bond‐Enhanced Photoreforming of Biomass Furans over a Urea‐Incorporated Cu(II) Porphyrin Framework
Authors: Zhang Yingchuan , Zhang Wanzhang , Zhang Fupeng , Xiao Yang , Jia Guangri , Wang Wenchao , Ke Fu‐Sheng , Guo Zhengxiao 
Published: April 2024

AbstractSolar‐driven upgrading of biomass‐derived 5‐hydroxylmethylfurfural (HMF) to 2,5‐furandicarboxylic acid (FDCA) holds great promise for sustainable production of bio‐plastics and resins. However, the process is limited by poor selectivity and sluggish kinetics due to the vertical coordination of HMF at relatively strong metal sites. Here, we purposely developed a Cu(II) porphyrin framework featuring side‐chain incorporated urea linkages, denoted as TBUPP−Cu MOF, to render HMF a weak hydrogen bond at the urea site and flat adsorption via π–π stacking with the benzene moiety. The unique configuration promotes the approaching of −CHO of HMF to the photoexcited porphyrin ring towards kinetically and thermodynamically favourable intermediate formation and subsequent desorption. The charge localisation and orbital energy alignment enable the selective activation of O2 over the porphyrin to generate ⋅O2− and 1O2 instead of highly oxidative H2O2 and ⋅OH via spin‐flip electron transfer, which drive the ambient oxidation of proximal −CHO. The effective utilisation of redox species and circumvented over‐oxidation facilitate a FDCA selectivity of >90 % with a high turnover number of 193 molHMF molCu−1. The facile purification of high‐purity FDCA and zero‐waste recycling of intermediates and durable catalyst feature TBUPP−Cu MOF a promising photo‐oxidation platform towards net‐zero biorefining and organic transformations.
Self‐assembled nanoparticles based on pullulan‐g‐poly(Z‐L‐lysine) for controlled drug delivery: Synthesis, characterization and preliminary studies on the encapsulation of indomethacin
Authors: Vieira T. A. , Matos L. , Carvalho L. T. , Alves G. M. , Lacerda T. M. , Medeiros S. F. 
Published: April 2024

AbstractNovel biocompatible systems suitable for the controlled release of active ingredients are under the spotlight within the last few years. The present investigation focuses on the preparation of nanoparticles (NPs) based on the amphiphilic copolymer pullulan‐graft‐poly(Z‐L‐lysine) bearing different amounts of lysine (10, 20, and 30 wt%), and on the evaluation of their ensuing viability to encapsulate the hydrophobic nonsteroidal anti‐inflammatory drug indomethacin (INDO). The copolymers are synthesized by ring‐opening polymerization, characterized by NMR and FTIR, and their critical aggregation concentration is determined by fluorescence. The NPs are prepared with and without INDO using different copolymer/solvent ratios and INDO/copolymer ratios. The hydrodynamic diameter and polydispersity of the NP suspensions are monitored by dynamic light scattering for 30 days. Their sizes vary between 208 and 338 nm, and some reach the micrometric range (19–73 μm). INDO‐free NPs are identified as spherical‐shaped by atomic force microscopy. Two formulations are tested in terms of encapsulation efficiency (EE = 43%–89%), and the drug crystallinity (DC = 7%–27%) which is determined by differential scanning calorimetry, indicating a reduction with respect to pristine INDO. The results suggest that the copolymers prepared herewith have potential to be applied as carriers for new drug delivery systems of class II drugs.
Synthesis and characterization of styrene‐maleic acid block copolymers with acrylic and methacrylic acids for potential use in membrane protein extraction
Authors: Khaojanta Thidarat , Punyamoonwongsa Patchara , Molloy Robert 
Published: April 2024

AbstractStyrene‐maleic acid (SMA) block copolymers with acrylic acid (AA) and methacrylic acid (MAA) were synthesized via a 3‐step process comprising: (1) photopolymerization of styrene and maleic anhydride in solution to yield an alternating styrene‐maleic anhydride (SMAnh) copolymer, (2) copolymerization of SMAnh with AA and MAA to yield SMAnh‐b‐AA and SMAnh‐b‐MAA block copolymers, and (3) base‐catalyzed hydrolysis of the anhydride groups to yield water‐soluble SMA‐b‐AA and SMA‐b‐MAA block copolymers. Copolymer compositions and average molecular weights were determined by the synthesis methodology used in which reversible chain transfer was a key component. Copolymer characterization was carried out by a combination of techniques, namely: ATR‐FTIR, 1H‐NMR, dilute‐solution viscometry, GPC, DSC, and TGA. These novel SMA block copolymers have been designed with a view to their use in membrane protein (MP) extraction from plant extracts and other naturally occurring substances of potential therapeutic value. The main function of the AA or MAA blocks is to widen the operational pH range of SMA in terms of (a) maintaining its water solubility at low pH and (b) stabilizing its MP assemblies in solution.
Bioavailability enhancement of coenzyme Q10: An update of novel approaches
Authors: Maciejewska‐Stupska Karolina , Czarnecka Kamila , Szymański Paweł 
Published: April 2024

AbstractCoenzyme Q10 (CoQ10) is an essential, lipid‐soluble vitamin involved in electron transport in the oxidoreductive reactions of the mitochondrial respiratory chain. Structurally, the quinone ring is connected to an isoprenoid moiety, which has a high molecular weight. Over the years, coenzyme Q10 has become relevant in the treatment of several diseases, like neurodegenerative disorders, coronary diseases, diabetes, hypercholesterolemia, cancer, and others. According to studies, CoQ10 supplementation might be beneficial in the treatment of CoQ10 deficiencies and disorders associated with oxidative stress. However, the water‐insoluble nature of CoQ10 is a major hindrance to successful supplementation. So far, many advancements in CoQ10 bioavailability enhancement have been developed using novel drug carriers such as solid dispersion, liposomes, micelles, nanoparticles, nanoemulsions, self‐emulsifying drug systems, or various innovative approaches (CoQ10 complexation with proteins). This article aims to provide an update on methods to improve CoQ10 solubility and bioavailability.
Personalization above anonymization? A role for considering the humanity and spirituality of the dead in anatomical education
Authors: Lazarus Michelle D. , Douglas Peter , Stephens Georgina C. 
Published: April 2024

AbstractClinical anatomy education is meant to prepare students for caring for the living, often by working with the dead. By their nature many clinical anatomy education programs privilege topographical form over the donor's humanity. This inbalance between the living and the dead generates tensions between the tangible and the spiritual insofar as semblances of the humanity of donors endure even in depictions and derivatives. This article argues that considering the relevance of spirituality, and what endures of a donor's humanity after death, would enhance contemporary anatomy education and the ethical treatment of human body donors (and derivatives). In developing this argument, we (the authors) address the historical connection between spirituality and anatomy, including the anatomical locations of the soul. This serves as a basis for examining the role of the mimetic—or imitative—potential of deceased human donors as representations of the living. We deliberate on the ways in which the depersonalization and anonymization of those donating challenge the mimetic purpose of human body donors and the extent to which such practices are misaligned with the health care shift from a biomedical to a biopsychosocial model. Weighing up the risks and opportunities of anonymization versus personalization of human body donors, we propose curricula that could serve to enhance the personalization of human donors to support students learning topographical form. In doing so, we argue that the personalization of human donors and depictions could prevent the ill effects of digital representations going “viral,” and enhance opportunities for donors to help the general public learn more about the human form.
Optimal control for networked control system with Markovian packet loss and delay
Authors: Wang Hongxia , Liu Tao , Li Zixing , Liang Xiao 
Published: April 2024

AbstractThis paper focuses on the optimal output‐feedback control and stabilization of a networked control system, where both time delay and packet loss are involved. Different from most previous work, the packet loss is Markovian, and the time delay occurs between the actuator and controller. The difficulty is rooted in the failure of the separation principle. The main tools are solving the delayed forward‐backward stochastic difference equations (D‐FBSDEs) and convergent analysis. Resorting to solving D‐FBSDEs and completing the square, we acquire the analytical solution, including the necessary and sufficient solvability condition and the explicit controller, of the finite‐horizon optimal control problem. Based on the finite‐horizon result and convergent analysis, we then obtain the analytical solution of the infinite‐horizon optimal control and stabilization problems. In addition, by analyzing the convergence of the optimal estimator, we establish a constraint relationship between the packet loss probability
and the system matrix
. The results are evaluated by numerical examples.
Event‐triggered secure control under denial‐of‐service attacks for cyber‐physical systems with positive constraint
Authors: Liu Jiao , Li Xiaopeng , Liu Yixian , Kang Le 
Published: April 2024

AbstractThis paper investigates the stabilization problem for cyber‐physical systems subject to positive constraint and denial‐of‐service (DoS) attacks using the event‐triggered scheme. Unlike traditional modeling of cyber physical systems with DoS attack, this paper establishes a positive switched system model composed of two positive subsystems that according to the DoS attack is active or inactive. Considering the effect of positive constraint and DoS attack, a 1‐norm‐based event‐triggered mechanism is proposed in the sleep interval of DoS attacks. By incorporating switching theory with event‐triggered mechanism, the sufficient condition of positive property and exponential stabilization for the considered system is established. Thereafter, the gain matrix of the controller is calculated by matrix decomposition technique. Furthermore, the Zeno behavior is eliminated with a lower bound of the event‐triggered interval. Finally, an example is carried out to verify the validity of the theoretical results.
Mechanical and Electrochemical Implications of Drying Temperature on Lithium‐Ion Battery Electrodes
Authors: Kukay Alexander , Polizos Georgios , Bott Emily , Ielvev Anton , Tao Runming , Sharma Jaswinder , Li Jianlin 
Published: April 2024

AbstractLithium‐ion battery (LIB) electrodes are typically produced with n‐methyl‐2‐pyrrolidone, a toxic solvent that is a known carcinogen and reproductive hazard. Accordingly, aqueous processing has been an expanding area of research interest in the field of LIB manufacturing. Although aqueous processing has been widely successful in anode processing, serious challenges remain in processing the cathode. In this work, the drying mechanics of cathode processed with both solvents is investigated though implementation of a chemical‐engineering‐based model to better understand the utilization of heat provided by experimentally determining the heat and mass transfer coefficients. Electrochemical performance is also evaluated to determine the impact of drying temperature on cycling performance. Binder distribution is determined via various methods to confirm differences in binder homogeneity as a function of both solvent and drying temperature. Identified is the large difference in the efficiency in which the heat is used as well as an ideal drying temperature for both aqueous and non‐aqueous processed cathodes. Also identified is the increased sensitivity to processing temperature for aqueous processed electrodes compared to non‐aqueous processed counterparts, pointing to the possibility of tuned drying regimes which would capitalize on the potential cost savings of aqueous processing for cathodes.
Advancing the agave‐soil nexus approach: A systematic review
Authors: Queiroz Hermano Melo , Ferreira Tiago Osório , Cerri Carlos Eduardo Pellegrino , Pereira Gonçalo Amarante Guimarães , Cherubin Maurício Roberto 
Published: April 2024

AbstractAgave plants, found primarily in arid and semi‐arid regions, have been utilized by indigenous communities for various purposes for thousands of years. They currently serve as crops to produce alcoholic beverages and fibers. Despite their importance, there is limited understanding of the relationship between agave and soil. This article addresses some of the knowledge gaps regarding the interactions and benefits of the agave‐soil approach. Among all the documents reviewed, 153 discussed individual soil parameters (45 physical, 68 chemical, and 40 biological), 59 explored interactions between them, and 130 did not address soil aspects (i.e., soil was merely presented as a substrate for the growth and development of plants and was not examined in the study's findings). Moreover, the historical evolution of the research highlights two distinct periods (from 1985 to 2000 and between 2010 to 2023) of notable publication activity, with recent years witnessing a surge in studies involving soil management techniques, genetic improvement of agave species, bioremediation, and the use of residues for bioenergy, biofuel, and soil amendments. There is a notable increasing trend in diverse research areas interested in these interactions, reflecting a broader recognition of the importance of understanding soil functioning in agave cultivation. Indeed, from 2010 to 2023, the use of the keyword ‘soil’ increased by 96% in studies of agave cultivation. This shift in research trends suggests that scientific advances in agave cultivation and soil science can be expected, contributing to sustainable agriculture and the long‐term viability of agave‐based industries. This article underscores an opportunity for further research to optimize agave cultivation and processing (e.g., soil management and productivity), for different purposes while conserving soil health and promoting sustainable land‐use practices.
Thienopyrimidine‐derived multifunctional fluorescence sensor for the detection of Cu2+, Fe3+, and PPi in different solvents
Authors: Shi Manman , Kang Mingyi , Liu Peng , Zhou Han , Pei Meishan , Zhang Guangyou , Yang Xiaofeng 
Published: April 2024

AbstractHydrazine substituted thienopyrimidine, a new fluorophore, was used to synthesize a novel Schiff base R1 as a chemosensor via the condensation with p‐formyltriphenylamine, and the structure was confirmed using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS) analysis. When treated with Cu2+ in dimethylsulfoxide (DMSO)/H2O buffer, R1 showed a phenomenon of fluorescence quenching, which was reversible with the action of ethylenediaminetetraacetic acid (EDTA). When treated with Fe3+ in dimethylformamide (DMF)/H2O buffer, R1 exhibited the same phenomenon, but fluorescence was recovered with inorganic pyrophosphate (PPi) quantitatively. The complexation ratios for R1‐Cu2+ and R1‐Fe3+ were both 1:2, which were manifested by MS titrations and corresponding Job's plots. The limits of detection of R1 for Cu2+ and Fe3+ were 3.11 × 10−8 and 1.24 × 10−7 M, respectively. The sensing mechanism of R1 toward Cu2+ and Fe3+ was confirmed using density functional theory calculations and electrostatic potential analysis. Test strips of R1 were fabricated successfully for on‐site detection of Cu2+ and Fe3+. In addition, R1 was applied to recognize Cu2+ and Fe3+ in actual water samples with satisfactory recovery.
Near‐infrared mechanoluminescence sensor: A new method for on‐site infrastructure detection
Authors: An Hongbin , Ju Haonan , Ren Zhiliang , Yang Hang , Huang Xinru , Tu Dong 
Published: April 2024

AbstractNear‐infrared mechanoluminescence is a phenomenon that produces high penetrating near‐infrared light under external stimulation. Near‐infrared light coincides with the biological window, lower optical loss, and the fact that the mechanoluminescence material is a medium that converts mechanical energy into light energy. The near‐infrared mechanoluminescence material has potential application prospects in the fields of biological imaging, medical diagnosis, and monitoring of building materials. In this article, we report on a perovskite‐type Sr3Sn2O7:Nd3+ near‐infrared mechanoluminescence material, and its peaks locate in the first near‐infrared window (800–1000 nm) and the second near‐infrared window (1080, 1350 nm), respectively. Under the condition of pre‐sintering with Li2CO3 as flux, the best sintering conditions are obtained, and the luminescence of material is in perfect agreement with the applied mechanical stress. In addition, a near‐infrared mechanoluminescence sensor is proposed to solve the problem of building damage and timely maintenance.
A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits
Authors: Chiang Hsueh‐Sheng , Mudar Raksha A. , Dugas Christine S. , Motes Michael A. , Kraut Michael A. , Hart John 
Published: April 2024

AbstractWord finding difficulty is a frequent complaint in older age and disease states, but treatment options are lacking for such verbal retrieval deficits. Better understanding of the neurophysiological and neuroanatomical basis of verbal retrieval function may inform effective interventions. In this article, we review the current evidence of a neural retrieval circuit central to verbal production, including words and semantic memory, that involves the pre‐supplementary motor area (pre‐SMA), striatum (particularly caudate nucleus), and thalamus. We aim to offer a modified neural circuit framework expanded upon a memory retrieval model proposed in 2013 by Hart et al., as evidence from electrophysiological, functional brain imaging, and noninvasive electrical brain stimulation studies have provided additional pieces of information that converge on a shared neural circuit for retrieval of memory and words. We propose that both the left inferior frontal gyrus and fronto‐polar regions should be included in the expanded circuit. All these regions have their respective functional roles during verbal retrieval, such as selection and inhibition during search, initiation and termination of search, maintenance of co‐activation across cortical regions, as well as final activation of the retrieved information. We will also highlight the structural connectivity from and to the pre‐SMA (e.g., frontal aslant tract and fronto‐striatal tract) that facilitates communication between the regions within this circuit. Finally, we will discuss how this circuit and its correlated activity may be affected by disease states and how this circuit may serve as a novel target engagement for neuromodulatory treatment of verbal retrieval deficits.
Can neurocognition, brain neurotrophic factor, triglyceride, and total cholesterol predict suicidal ideation in first‐episode Han Chinese patients with schizophrenia?
Authors: Dongxia Li , Li Ma , Yingying Feng 
Published: April 2024

AbstractObjectivePrevious studies have suggested that the suicide rate of patients with schizophrenia is high. This study investigates factors influencing suicidal ideation in first‐episode schizophrenia patients, focusing on cognitive function, brain‐derived neurotrophic factor (BDNF), triglyceride (TG), and total cholesterol (TC) in patients with first‐episode schizophrenia.MethodsA total of 123 patients with first‐episode schizophrenia and 38 healthy controls were included in the study. The patients were divided into suicidal and nonsuicidal ideation groups based on the Beck Scale for Suicidal Ideation, and they were assessed with Positive and Negative Syndrome Scale (PANSS). Cognitive function was assessed using the Chinese version of the MATRICS consensus cognitive battery (MCCB) and the serum BDNF, TG, and TC were detected. The main statistical methods include t‐test, χ2 test, multivariate logistic regression analysis, receiver operating characteristic (ROC) curve analysis, and the DeLong test.Results26.02% of patients exhibited suicidal ideation. Higher PANSS and TC levels were risk factors, while higher MCCB scores and BDNF levels were protective factors. ROC analysis indicated AUCs of 0.630, 0.724, and 0.762 for serum BDNF, PANSS, and MCCB, respectively, with a combined AUC of 0.870.ConclusionSerum BDNF level, PANSS score, and MCCB score can be used as auxiliary predictors of suicidal ideation in schizophrenic patients. Combining these three indicators can effectively predict suicidal ideation in schizophrenic patients.
Organisational practices and social inclusion: Inclusionary place‐making in the library
Authors: Kerr Rosslyn , Hopkins Nick 
Published: April 2024

AbstractSocial psychology has long been concerned with social exclusion. Much of this interest has focused on people's negative intergroup attitudes and how these may be changed through individual‐level interventions. In this paper we explore a different level of intervention – one that targets the routine organisational practices that communicate who is welcome and able to draw on the organisation's services. Specifically, we investigate how a public‐facing organisation—a library service—engaged in a process of self‐reflection on its routine social practices with the aim of making people experiencing various forms of exclusion (e.g., job seekers, benefit claimants, ethnic minorities) more welcome. Our data arise from interviews (N = 19) with staff concerning their attempts to transform the practices that constitute the library as a distinctive public place. Throughout, we explore how they reflected on their everyday organisational practices, how these may unintentionally exclude, and how they could be modified to facilitate social inclusion. Moreover, we pay particular attention to our participants' understanding of the challenges involved in changing organisational culture and creating a social space in which diversity is accepted.
Metabolomic Profiling and DNA‐Fingerprinting of Newly Recorded White‐Flowered Populations of Salvia lanigera Poir. in Egypt
Authors: Farid Mai M. , Marzouk Mona M. , Ivanova Viktoria , Nedialkov Paraskev , El Shabrawy Mona O. , Kawashty Salwa A. , Sakr Mahmoud M. , Hussein Sameh R. , Trendafilova Antoaneta 
Published: April 2024

AbstractSalvia lanigera Poir. is a small herbaceous perennial species with violet flowers that grows in low‐altitude deserts, and sandy loam. During the collection of S. lanigera, unusual populations with white flowers were found. Therefore, the two populations (violet‐ and white‐flowered) were subjected to comparative investigations, including DNA fingerprinting, chemical composition, and biological evaluation. The two populations showed DNA variations, with 6.66 % polymorphism in ISSR and 25 % in SCoT markers. GC/MS and UHPLC/HRMS of aqueous methanol extracts, led to the tentative identification of 43 and 50 compounds in both populations. In addition, the structures of nine compounds, including four first‐time reported compounds in the species, were confirmed by NMR. Furthermore, the total extracts exhibited weak radical scavenging activity against DPPH and a lower inhibitory effect towards acetylcholinesterase. In conclusion, the obtained data suggested that the white‐colored flower could be an additional important character record for the Egyptian S. lanigera.