bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantitative cellular pathology of the amygdala in temporal lobe epilepsy and correlation with magnetic resonance imaging volumetry, tissue microstructure, and sudden unexpected death in epilepsy risk factors
Authors: Lam Hou Wang , Patodia Smriti , Zeicu Claudia , Lim Yau Mun , Mrzyglod Alicja , Scott Catherine , Oliveira Joana , De Tisi Jane , Legouhy Antoine , Zhang Hui , Koepp Matthias , Diehl Beate , Thom Maria 
Published: June 2024

AbstractObjectiveAmygdala enlargement can occur in temporal lobe epilepsy, and increased amygdala volume is also reported in sudden unexpected death in epilepsy (SUDEP). Apnea can be induced by amygdala stimulation, and postconvulsive central apnea (PCCA) and generalized seizures are both known SUDEP risk factors. Neurite orientation dispersion and density imaging (NODDI) has recently provided additional information on altered amygdala microstructure in SUDEP. In a series of 24 surgical temporal lobe epilepsy cases, our aim was to quantify amygdala cellular pathology parameters that could predict enlargement, NODDI changes, and ictal respiratory dysfunction.MethodsUsing whole slide scanning automated quantitative image analysis methods, parallel evaluation of myelin, axons, dendrites, oligodendroglia, microglia, astroglia, neurons, serotonergic networks, mTOR‐pathway activation (pS6) and phosphorylated tau (pTau; AT8, AT100, PHF) in amygdala, periamygdala cortex, and white matter regions of interest were compared with preoperative magnetic resonance imaging data on amygdala size, and in 13 cases with NODDI and evidence of ictal‐associated apnea.ResultsWe observed significantly higher glial labeling (Iba1, glial fibrillary acidic protein, Olig2) in amygdala regions compared to cortex and a strong positive correlation between Olig2 and Iba1 in the amygdala. Larger amygdala volumes correlated with lower microtubule‐associated protein (MAP2), whereas higher NODDI orientation dispersion index correlated with lower Olig2 cell densities. In the three cases with recorded PCCA, higher MAP2 and pS6‐235 expression was noted than in those without. pTau did not correlate with SUDEP risk factors, including seizure frequency.SignificanceHistological quantitation of amygdala microstructure can shed light on enlargement and diffusion imaging alterations in epilepsy to explore possible mechanisms of amygdala dysfunction, including mTOR pathway activation, that in turn may increase the risk for SUDEP.
Learning, memory and blood–brain barrier pathology in Duchenne muscular dystrophy mice lacking Dp427, or Dp427 and Dp140
Authors: Verhaeg Minou , Adamzek Kevin , van de Vijver Davy , Putker Kayleigh , Engelbeen Sarah , Wijnbergen Daphne , Overzier Maurice , Suidgeest Ernst , van der Weerd Louise , Aartsma‐Rus Annemieke , van Putten Maaike 
Published: June 2024

AbstractDuchenne muscular dystrophy is a severe neuromuscular disorder that is caused by mutations in the DMD gene, resulting in a disruption of dystrophin production. Next to dystrophin expression in the muscle, different isoforms of the protein are also expressed in the brain and lack of these isoforms leads to cognitive and behavioral deficits in patients. It remains unclear how the loss of the shorter dystrophin isoform Dp140 affects these processes. Using a variety of behavioral tests, we found that mdx and mdx4cv mice (which lack Dp427 or Dp427 + Dp140, respectively) exhibit similar deficits in working memory, movement patterns and blood–brain barrier integrity. Neither model showed deficits in spatial learning and memory, learning flexibility, anxiety or spontaneous behavior, nor did we observe differences in aquaporin 4 and glial fibrillary acidic protein. These results indicate that in contrast to Dp427, Dp140 does not play a crucial role in processes of learning, memory and spontaneous behavior.
Towards a historical geography of girlhood
Authors: Krishnan Sneha 
Published: June 2024

AbstractThis paper makes an argument for a geography of girlhood, located at the intersection of historical geographies of globalisation and empire on the one hand, and feminist interventions in the geography of childhood and youth on the other. A focus on girlhood, I argue, opens up a debate on the discipline's own implication in a debate on climate science, moral hierarchies of civilisation and reproductive health at which intersection the category of ‘girl’ was materialised in the 19th century. This focus extends and historicises the argument made by scholars like Nicola Ansel that geographies of childhood speak not only to intimate scales of experience ‐ such as the home and neighbourhood—but instead suggest the ways in which everyday life is implicated in the scale of the global and the geopolitical. Drawing on an inter‐disciplinary scholarship, the paper argues that debates on gender and maturity—converging on the figure of the ‘girl’—shaped raced and classed imaginaries of progress in the 19th and 20th centuries. Through this, the paper demonstrates that ‘girlhood’ is at the heart of historical geographies of urban planning, social care, and health, as well as indexing the continuities in the transition from a colonial discourse of civilisation to a mid‐20th century concern with development. Finally, the paper asks how to write about girls through an archive that is almost obsessively fixated on them as subjects of education and reform, even whilst they rarely appear in it as speaking subjects. I argue that both an emergent focus on non‐textual objects as sources, as well as the use of ephemeral material—including notes, creative writing exercises from the classroom, school diaries etc.—alongside the official archive might open the scholarship up to a multi‐scalar analysis of girlhood as imbricated in larger global and national discursive and material practices.
Strategies for involving patients and the public in scaling initiatives in health and social services: A scoping review
Authors: de Carvalho Corôa Roberta , Ben Charif Ali , Robitaille Vincent , G. V. Mochcovitch Diogo , Abdoulaye Samri Mamane , Akpo Talagbe Gabin , Gogovor Amédé , Blanchette Virginie , Gomes Souza Lucas , Kastner Kathy , M. Achim Amélie , McLean Robert K. D. , Milat Andrew , Légaré France ,   The RePOS Network
Published: June 2024

AbstractBackgroundScaling in health and social services (HSS) aims to increase the intended impact of proven effective interventions. Patient and public involvement (PPI) is critical for ensuring that scaling beneficiaries’ interests are served. We aimed to identify PPI strategies and their characteristics in the science and practice of scaling in HSS.MethodsIn this scoping review, we included any scaling initiative in HSS that used PPI strategies and reported PPI methods and outcomes. We searched electronic databases (e.g., Medline) from inception to 5 February 2024, and grey literature (e.g., Google). Paired reviewers independently selected and extracted eligible reports. A narrative synthesis was performed and we used the PRISMA for Scoping Reviews and the Guidance for Reporting Involvement of Patients and the Public (GRIPP2).FindingsWe included 110 unique reports out of 24,579 records. In the past 5 years, the evidence on PPI in scaling has increased faster than in any previous period. We found 236 mutually nonexclusive PPI strategies among 120 scaling initiatives. Twenty‐four initiatives did not target a specific country; but most of those that did so (n = 96) occurred in higher‐income countries (n = 51). Community‐based primary health care was the most frequent level of care (n = 103). Mostly, patients and the public were involved throughout all scaling phases (n = 46) and throughout the continuum of collaboration (n = 45); the most frequently reported ethical lens regarding the rationale for PPI was consequentialist‐utilitarian (n = 96). Few papers reported PPI recruitment processes (n = 31) or incentives used (n = 18). PPI strategies occurred mostly in direct care (n = 88). Patient and public education was the PPI strategy most reported (n = 31), followed by population consultations (n = 30).ConclusionsPPI in scaling is increasing in HSS. Further investigation is needed to better document the PPI experience in scaling and ensure that it occurs in a meaningful and equitable way.Patient and Public ContributionTwo patients were involved in this review. They shared decisions on review questions, data collection instruments, protocol design, and findings dissemination.Review RegistrationOpen Science Framework on 19 August 2020 (https://osf.io/zqpx7/).
SARS‐CoV‐2 Seroprevalence Trends in the Netherlands in the Variant of Concern Era: Input for Future Response
Authors: Vos Eric R. A. , van Hagen Cheyenne C. E. , Wong Denise , Smits Gaby , Kuijer Marjan , Wijmenga‐Monsuur Alienke J. , Kaczorowska Joanna , van Binnendijk Robert S. , van der Klis Fiona R. M. , den Hartog Gerco , de Melker Hester E. 
Published: June 2024

ABSTRACTBackgroundTo inform future response planning we aimed to assess SARS‐CoV‐2 trends in infection‐ and/or vaccine‐induced immunity, including breakthrough infections, among (sub)groups, professions and regions in the Dutch population during the Variant of Concern (VOC)‐era.MethodsIn this prospective population‐based cohort, randomly selected participants (n = 9985) aged 1–92 years (recruited early‐2020) donated home‐collected fingerstick‐blood samples at six timepoints in 2021/2022, covering waves dominated by Alpha, Delta, and multiple Omicron (sub‐)variants. IgG antibody assessment against Spike‐S1 and Nucleoprotein was combined with vaccination‐ and testing data to estimate infection‐induced (inf) and total (infection‐ and vaccination‐induced) seroprevalence.ResultsNationwide inf‐seroprevalence rose modestly from 12% (95% CI 11–13) since Alpha to 26% (95% CI 24–28) amidst Delta, while total seroprevalence increased rapidly to 87% (95% CI 85–88), particularly in elderly and those with comorbidities (i.e., vulnerable groups). Interestingly, highest infection rates were noticeable among low/middle educated elderly, non‐Western, those in contact professions, adolescents and young adults, and in low‐vaccination coverage regions. Following Omicron emergence, inf‐seroprevalence elevated sharply to 62% (95% CI 59–65) and further to 86% (95% CI 83–90) in late‐2022, with frequent breakthrough infections and decreasing seroprevalence dissimilarities between most groups. Whereas > 90% of < 60‐year‐olds had been infected at least once, 30% of vaccinated vulnerable individuals had still not acquired hybrid immunity.ConclusionsGroups identified to have been infected disproportionally during the acute phase of the pandemic require specific attention in evaluation of control measures and future response planning worldwide. Furthermore, ongoing tailored vaccination efforts and (sero‐)monitoring of vulnerable groups may remain important.
Enhanced oxidation resistance of HfB2‐SiC‐ZrSi2 coating at 1700°C through low‐loss film‐forming treatment
Authors: Zhang Menglin , Ji Xiang , Zhang Youkui , Chen Yuexing , Wang Peipei , Kiryukhantsev‐Korneev Philipp V. , Levashov Evgeny A. , Shi Ji , Ren Xuanru , Kang Xueqin , Zhang Baojing , Zhang Ping , Feng Peizhong 
Published: June 2024

AbstractTo enhance the oxidation resistance of HfB2‐SiC‐ZrSi2 coating, low‐loss film‐forming treatment (LFT) was employed to generate high‐quality oxygen barrier glass layers, and the modification effect of varying formation temperature on the oxidation resistance was investigated at 1700°C. The results demonstrated that, with LFT at 1500°C, the relatively modest oxidation activity and complete dispersion of metal oxide nanocrystals generated a compact and continuous composite glass layer, which caused a decreased oxidation activity at 1700°C. The excessive formation temperature might result in oxidized and porous coatings, while lower temperatures could lead to poor fluidity of the glass layer, rendering it challenging to achieve compact composite glass layers. The coating sample with LFT at 1500°C exhibited a carbon loss rate of 0.33 × 10−6 g·cm−2·s−1 and an oxygen permeability level of 0.28%, respectively, when oxidized at 1700°C. These results provide fundamental insights into the oxidation resistance mechanisms within the modified HfB2‐SiC‐ZrSi2 coating system.
Natural killer cell‐related anti‐tumour adoptive cell immunotherapy
Authors: Qi Yuwen , Li Ying , Wang Hua , Wang Anjin , Liu Xuelian , Liang Ziyan , Gao Yang , Wei Liqing 
Published: June 2024

AbstractChimeric antigen receptor‐ (CAR‐)modified T cells have been successfully used to treat blood cancer. With the improved research on anti‐tumour adoptive cell therapy, researchers have focused on immune cells other than T lymphocytes. Natural killer (NK) cells have received widespread attention as barriers to natural immunity. Compared to T lymphocyte‐related adoptive cell therapy, the use of NK cells to treat tumours does not cause graft‐versus‐host disease, significantly improving immunity. Moreover, NK cells have more sources than T cells, and the related modified cells are less expensive. NK cells function through several pathways in anti‐tumour mechanisms. Currently, many anti‐tumour clinical trials have used NK cell‐related adoptive cell therapies. In this review, we have summarized the recent progress in NK cell‐related adoptive cellular immunotherapy for tumour treatment and propose the current challenges faced by CAR‐NK cell therapy.
Fuzzy‐PID controller based on improved LFPSO for temperature and humidity control in a CA ripening system
Authors: Zhou Haiyi , Wu Junhui , Zheng Xinnan , Zhu Hongfei , Lu Guangjun , Zhang Yalei , Shen Zheng 
Published: June 2024

AbstractTemperature and humidity as the key factors affecting the storage and ripening of fruits and vegetables directly determine the quality of fruits and vegetables. In this paper, a temperature and humidity model was constructed based on an integrated device of controlled atmosphere storage and ripening. Aiming at the shortcomings of the temperature and humidity model such as large inertia, nonlinearity, and model uncertainty, a fuzzy‐PID controller based on the improved Lévy flight particle swarm algorithm (LFPSO) is proposed. Initially, a mathematical model of temperature and humidity is developed through mechanism research and parameter estimation. Subsequently, a temperature and humidity fuzzy‐PID control strategy is proposed for regulating temperature and humidity. An improved LFPSO is then introduced to optimize the key parameters of the fuzzy‐PID controller, such as the quantization factor and the scale factor. The superiority of the improved LFPSO algorithm is verified by comparing the test functions. Finally, the improved LFPSO‐fuzzy‐PID controller, fuzzy‐PID controller, and Smith‐PID controller are applied to the simulation model for comparison using the MATLAB Simulink simulation platform. The results show that the improved LFPSO‐fuzzy‐PID control algorithm has a good control effect in the temperature and humidity simulation system of controlled atmosphere (CA) ripening container, which provides a reference for solving the optimization problem of actual engineering design.Practical applicationsIn order to reduce the postharvest cold chain losses of fruits and vegetables, this paper proposes a containerized style device that combines fruits and vegetables storage and ripening for simplifying the losses caused by transshipment at cold chain nodes. Since temperature and humidity play a key role in fruits and vegetables storage and ripening, which directly affect the product quality, this paper establishes a complete mathematical model of CA ripening temperature and humidity system by combining mechanism modeling and parameter identification. In order to keep the temperature and humidity within the ideal range, Smith‐PID controller, fuzzy‐PID controller, and fuzzy‐PID control method based on improved Lévy flight particle swarm optimization are proposed to regulate the air conditioner and humidifier. The performance of three different types of controllers was tested on the MATLAB. The simulation results demonstrate that the improved LFPSO‐fuzzy‐PID controller is superior and more effective than Smith‐PID and fuzzy‐PID controllers.
Effectiveness of integrated care for older adults‐based interventions on depressive symptoms: A systematic review and meta‐analysis
Authors: Liu Wei , Qin Rixin , Zhang Xueyan , Li Guichen , Qiu Yiming , Huang Kexin , Li Xin , Chen Li , Xiao Jun 
Published: June 2024

AbstractAimTo pool existing studies to assess the overall effectiveness of integrated care for older adults (ICOPE)‐based interventions in improving depressive symptoms in older adults.DesignA systematic review and meta‐analysis.Data SourcesTen databases were systematically searched from inception to 15 July 2023 and the search was last updated on 2 September 2023.MethodsStandardized mean difference (SMD) was calculated using random effects models. RoB 2 and GRADEpro GDT were used to assess the methodological quality and confidence in the cumulative evidence. Funnel plots, egger's test and begg's test were used to analyse publication bias. Sensitivity, subgroup and meta‐regression analyses were performed to explore potential sources of heterogeneity.ResultsThe results of 18 studies showed ICOPE‐based interventions had a significant effect on improving depressive symptoms (SMD = −.84; 95% CI, −1.20 to −.3647; p < .001; 18 RCTs, 5010 participants; very low‐quality evidence). Subgroup analysis showed the intervention group was characterized by mean age (70–80 years old), intervention duration between 6 to 12 months, gender (female <50%), non‐frail older adults, depressed older adults and mixed integration appeared to be more effective. Sensitivity analysis found the results to be robust.ConclusionICOPE‐based interventions may be a potentially effective alternative approach to reduce depressive symptoms in the older adults.Implications for the Profession and/or Patient CareHealthcare professionals are expected to use ICOPE as one of the interventions for depressive symptoms in older adults, and this ICOPE could provide more comprehensive care services for older adults to reduce depressive symptoms.Impact

ICOPE‐based interventions may be a potentially effective alternative approach to reduce depressive symptoms in the older adults.

ICOPE‐based interventions had a significant effect on reducing depressive symptoms in the older adults.

The intervention group characterized by mean age of older adults, intervention duration, gender ratio, health condition and integration types may influence the effect size.

Reporting MethodAccording to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines.Patient or Public ContributionNo Patient or Public Contribution.
The exchange rate pass‐through to domestic prices: A meta‐analysis
Authors: Iorngurum Tersoo David 
Published: June 2024

AbstractEstimates of the exchange rate pass‐through vary significantly across studies. Therefore, I conduct a meta‐analysis to understand why estimates differ and provide consensus for the conflicting results. The dataset includes 72 primary studies containing 1219 estimates of the pass‐through from nominal effective exchange rates to consumer prices for 111 countries. Because there are many potential causes of heterogeneity, I use Bayesian model averaging to identify the important ones. I find that results vary mainly due to a combination of country‐specific and methodological characteristics, even though factors such as asymmetry and product‐specific characteristics also play a role. The country‐specific characteristics include trade openness, exchange rate flexibility, economic development status, exchange rate persistence, and commodity dependence. On the other hand, the methodological factors include estimation methods, data characteristics, endogeneity bias, and the researcher's choice of control variables. Finally, I model the exchange rate pass‐through, taking into account asymmetry and the best practices in the literature. I find that a 1% increase in the exchange rate leads to a 0.09% decrease in the consumer price level, whereas a 1% decrease leads to a 0.19% increase.
Recent stressful life events and identity development in emerging adults: An examination of within‐person effects
Authors: Wong Tracy K. , Hamza Chloe A. 
Published: June 2024

AbstractObjectiveTo examine longitudinal associations among stressful life events and identity processess in emerging adults while accounting for within‐person and between‐person effects.BackgroundTheoretical perspectives suggest that stressful life events may impact one's identity (i.e., coherent sense of self), but few studies have considered how changes in stressful life events are associated with changes within an individual's identity development over time (within‐person effects).Methods Recent stressful life events (i.e., academic problems, friendship problems, romantic problems, and time pressure) and the processes through which identity develops (e.g., exploring in breadth and depth) were examined longitudinally (T1–T3) in a sample of emerging adults (N = 1125, Mage = 17.96 years).ResultsRandom‐intercept cross‐lagged modeling demonstrated that at the between‐person level, emerging adults with greater academic and friendship problems, as well as more time pressures (relative to their counterparts), tended to engage in greater ruminative exploration. Further, those with more academic problems tended to demonstrate weaker commitment‐making and exploration in breadth and depth (relative to their counterparts). Within‐person increases in romantic problems predicted lower commitment‐making and higher ruminative exploration over time.ConclusionFindings suggest that romantic problems may predict within‐person changes in identity processes, whereas academic problems, friendship problems, and time pressure may be more concurrently related to identity development.
A revision of the genusWrangelia(Wrangeliaceae, Ceramiales) in Bermuda resolves six new species includingW. ryancraigiifrom the mesophotic zone
Authors: Jongbloed Walter M. , Schneider Craig W. , Lane Christopher E. , Cassidy Margaret M. , Saunders Gary W. 
Published: June 2024

AbstractFour species of the genusWrangeliaare presently known from the western Atlantic Ocean:W. argus,W. bicuspidata,W. penicillata,andW. gordoniae, with the first three historically being reported from Bermuda. Morphological and molecular barcode (COI‐5P) and phylogenetic analyses used in this study (SSU, LSU,rbcL) indicated eight species groupings ofWrangeliain Bermuda, excluding two of the historically recognized species, retaining onlyW. arguswhile adding seven new species, of which six are formally described. What had been historically reported asW. penicillatafrom Bermuda was shown to be distinct from Mediterranean Sea specimens (type locality) and was shown to be a mixture ofW. hesperiasp. nov. andW. incrassatasp. nov. Along with these two, three other new species (W. laxasp. nov.,W. ryancraigiisp. nov., andW. secundirameasp. nov.) have complete rhizoidal cortication tightly covering axial cells of indeterminate axes below the apices, distinguishing them from the two local incompletely corticated congenersW. argusandW. absconditasp. nov., the latter a morphologically cryptic sister species withW. bicuspidatafrom the Caribbean Sea. Only one of the new species,W. ryancraigii, has thus far been observed in the mesophotic zone off the Bermuda platform, and it is morphologically cryptic with the euphotic zone'sW. laxa.