bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic significance of FOXP1 as an oncogene in hepatocellular carcinoma
Authors: Zhang Yixin , Zhang Suqin , Wang Xudong , Liu Jibin , Yang Liping , He Song , Chen Li , Huang Jianfei 
Published: March 2012

BackgroundForkhead Box P1 (FOXP1) has been described as both a tumour suppressor candidate and a potential oncogene. The aim of this study is to identify new prognostic biomarkers and therapeutic target structures for the diagnosis and treatment of hepatocellular carcinoma (HCC).MethodsThe expression of FOXP1 mRNA in HCC was characterised using real-time PCR and 20 pairs of fresh frozen HCC tissues and corresponding non-cancerous tissues. FOXP1 protein expression in HCC was confirmed using immunohistochemistry on a tissue microarray chip. Finally, FOXP1 expression was correlated with conventional clinicopathological features of HCC and patient outcome.ResultsThe expression of FOXP1 mRNA and protein in HCC cells was much higher than in normal hepatic cells (Z=2.315, p=0.021 and χ2=28.071, 95% CI 0.233 to 0.480, p<0.001, individually). The comparison of clinicopathological characteristics and immunohistochemistry by χ2test analysis showed that the high expression of FOXP1 in HCC was related to large tumour diameter (χ2=6.210, p=0.013), high serum α-fetoprotein levels (χ2=6.920, p=0.031) and later stage grouping with tumour node metastasis classification (χ2=6.714, p=0.035). Kaplan–Meier survival and Cox regression analysis showed that high FOXP1 expression (HR=2.182, 95% CI 1.146 to 4.154, p=0.018) and regional lymph node metastasis (HR=2.326, 95% CI 1.037 to 5.217, p=0.041) were independent prognosis factors.ConclusionsFrom this investigation the authors elucidated for the first time that the correlation of high FOXP1 expression correlates with an aggressive malignant phenotype and may constitute a novel prognostic factor for HCC. These results also support a role for FOXP1 as an oncogene in HCC.
Contemporaneous eruption of Nb-enriched basalts – K-adakites – Na-adakites from the 2.7 Ga Penakacherla terrane: implications for subduction zone processes and crustal growth in the eastern Dharwar craton, India
Authors: Kerrich Robert , Manikyamba Chakravadhanula 
Published: March 2012

An association of Nb-enriched basalts (NEB), high-MgO andesites (HMA), and flows with adakitic characteristics are interlayered with tholeiitic pillow basalts in the 2.7 Ga Penakacherla greenstone belt of eastern Dharwar craton. Two populations of basalt are present, a high-Mg# Ni (0.65–0.56, 106–52 ppm) and low-Mg# Ni (0.45–0.34, 32–13 ppm) counterpart; Nb spans 6.3–18 ppm relative to “normal” arc tholeiitic basalts, where Nb ∼3 ppm, and hence qualify as NEB. Basalts plot on the low-Ce/Yb trend of intraoceanic arcs, and have fractionated heavy rare-earth elements (HREE) indicative of melting with residual garnet at >90 km. Ratios of Nb/Ta (7.6 ± 0.7), Zr/Hf (44 ± 0.8), and Zr/Sm (27 ± 2.4) are systematically low, high, and similar to respective primitive mantle ratios of 17, 36, and 25, consistent with a mid-ocean ridge basalt-like mantle source in the sub-arc mantle wedge. Intermediate compositions are divided into high-K but low-Na (K2O 1.8–5.3; Na2O 0.5–2.1 wt.%) and low-K but high-Na (K2O 0.10–1.5; Na2O 4.1–5.6 wt.%) populations defining distinct magma series; accordingly, these are termed K-adakitic and Na-adakitic rocks, respectively. The Na-type has SiO2 ≥56 wt.%, MgO <3 wt.%, Mg# ∼0.5, Na2O ≥3.5 wt.%, K2O ≤3 wt.%, Yb ≤1.9 ppm, Cr ≥30 ppm, with slightly lower limits of Al2O3 ≥15 wt.% and La/Yb 7.5–8.2 versus ≥20, thus conforming to most criteria for Na-adakites. NEB are interpreted as melts of mantle wedge hybridized by adakitic melts having residual garnet; and Na-adakites are slab melts of low-Mg basalt in the garnet–amphibolite facies. K-adakitic flows are melts of mafic lower crust, or melts of lower crust delaminated into mantle wedge asthenosphere.
ON THE OPTIMAL POLYNOMIAL APPROXIMATION OF STOCHASTIC PDES BY GALERKIN AND COLLOCATION METHODS
Authors: BECK JOAKIM , TEMPONE RAUL , NOBILE FABIO , TAMELLINI LORENZO 
Published: March 2012

In this work we focus on the numerical approximation of the solution u of a linear elliptic PDE with stochastic coefficients. The problem is rewritten as a parametric PDE and the functional dependence of the solution on the parameters is approximated by multivariate polynomials. We first consider the stochastic Galerkin method, and rely on sharp estimates for the decay of the Fourier coefficients of the spectral expansion of u on an orthogonal polynomial basis to build a sequence of polynomial subspaces that features better convergence properties, in terms of error versus number of degrees of freedom, than standard choices such as Total Degree or Tensor Product subspaces. We consider then the Stochastic Collocation method, and use the previous estimates to introduce a new class of Sparse Grids, based on the idea of selecting a priori the most profitable hierarchical surpluses, that, again, features better convergence properties compared to standard Smolyak or tensor product grids. Numerical results show the effectiveness of the newly introduced polynomial spaces and sparse grids.
Phase I Study of Vincristine, Irinotecan, and 131I-Metaiodobenzylguanidine for Patients with Relapsed or Refractory Neuroblastoma: A New Approaches to Neuroblastoma Therapy Trial
Authors: DuBois Steven G. , Chesler Louis , Groshen Susan , Hawkins Randall , Goodarzian Fariba , Shimada Hiroyuki , Yanik Greg , Tagen Michael , Stewart Clinton , Mosse Yael P. , Maris John M. , Tsao-Wei Denice , Marachelian Araz , Villablanca Judith G. , Matthay Katherine K. 
Published: March 2012

Abstract
Purpose:131I-metaiodobenzylguanidine (MIBG) is a targeted radiopharmaceutical with activity in patients with relapsed or refractory neuroblastoma. Irinotecan is a known radiosensitizer with activity in neuroblastoma. This phase I study aimed to determine the recommended phase 2 dose of MIBG together with fixed doses of vincristine and irinotecan.
Experimental Design: Patients 1 to 30 years old with relapsed or refractory neuroblastoma and MIBG-avid tumors were eligible. All patients had autologous hematopoietic stem cells (PBSC) available and met standard phase I organ function requirements. Irinotecan (20 mg/m2/dose IV) was given on days 0 to 4 and 7 to 11, with vincristine (1.5 mg/m2 IV) on days 0 and 7. MIBG was given on day 1 following a 3 + 3 phase I dose escalation design starting at 8 mCi/kg MIBG. PBSCs were administered at dose level 8 mCi/kg for prolonged myelosuppression and for all patients at 12 mCi/kg or more.
Results: Twenty-four patients evaluable for dose escalation (median age, 6.7 years; range, 1.9–26.8 years) received 1 (n = 17), 2 (n = 5), or 3 (n = 2) cycles of therapy. Myelosuppression and diarrhea were the most common toxicities. Two of 6 patients at the 18 mCi/kg dose level had dose-limiting toxicity (DLT), including one with protocol-defined DLT with prolonged mild aspartate aminotransferase elevation. Eighteen mCi/kg was the recommended phase 2 dose. Six additional patients were treated at 18 mCi/kg, with one additional DLT. Responses (2 complete and 4 partial responses) occurred in 6 of 24 (25%) evaluable patients.
Conclusions: MIBG is tolerable and active at 18 mCi/kg with standard doses of vincristine and irinotecan. Clin Cancer Res; 18(9); 2679–86. ©2012 AACR.
Drug Interactions: The Importance of Looking Inside Cancer Cells
Authors: Clark Jeffrey W. 
Published: March 2012

Abstract
nab-Paclitaxel increased intratumoral gemcitabine levels by reactive oxygen species–mediated degradation of cytidine deaminase, the rate-limiting enzyme in gemcitabine inactivation. This not only has implications for how this drug combination mediates anticancer effects but also demonstrates the importance of evaluating mechanisms of drug activity within malignant cells. Cancer Discovery; 2(3); 208–10. ©2012 AACR.
Commentary on Frese et al., p. 260.
PDGF-Induced Migration of Vascular Smooth Muscle Cells Is Inhibited by Heme Oxygenase-1 Via VEGFR2 Upregulation and Subsequent Assembly of Inactive VEGFR2/PDGFRβ Heterodimers
Authors: Cheng Caroline , Haasdijk Remco A. , Tempel Dennie , den Dekker Wijnand K. , Chrifi Ihsan , Blonden Lau A.J. , van de Kamp Esther H.M. , de Boer M. , Bürgisser Petra E. , Noorderloos Annemarie , Rens Joost A.P. , ten Hagen Timo L.M. , Duckers Henricus J. 
Published: March 2012

Objective—
In cardiovascular regulation, heme oxygenase-1 (HO-1) activity has been shown to inhibit vascular smooth muscle cell (VSMC) proliferation by promoting cell cycle arrest at the G1/S phase. However, the effect of HO-1 on VSMC migration remains unclear. We aim to elucidate the mechanism by which HO-1 regulates PDGFBB-induced VSMC migration.

Methods and Results—
Transduction of HO-1 cDNA adenoviral vector severely impeded human VSMC migration in a scratch, transmembrane, and directional migration assay in response to PDGFBB stimulation. Similarly, HO-1 overexpression in the remodeling process during murine retinal vasculature development attenuated VSMC coverage over the major arterial branches as compared with sham vector-transduced eyes. HO-1 expression in VSMCs significantly upregulated VEGFA and VEGFR2 expression, which subsequently promoted the formation of inactive PDGFRβ/VEGFR2 complexes. This compromised PDGFRβ phosphorylation and impeded the downstream cascade of FAK-p38 signaling. siRNA-mediated silencing of VEGFA or VEGFR2 could reverse the inhibitory effect of HO-1 on VSMC migration.

Conclusion—
These findings identify a potent antimigratory function of HO-1 in VSMCs, a mechanism that involves VEGFA and VEGFR2 upregulation, followed by assembly of inactive VEGFR2/PDGFRβ complexes that attenuates effective PDGFRβ signaling.
The story of Dharmaruci In the Divyāvadāna and Kemendra's Bodhisattvāvadānakalpalatā
Authors: Silk Jonathan A. 
Published: March 2012

AbstractOf the myriad tales found in Indian Buddhist literature, the story of Dharmaruci is, from many points of view, among the more interesting, engaging as it does iconic themes of incest and patricide. A great deal may be said about this story, particularly in comparison with the tale of Mahādeva, the schismatic monk blamed by some for the initial rupture in the Buddhist monastic community roughly a century after the death of the Buddha. Any detailed study of this story, as of any such story, however, naturally requires the best possible textual sources. The present contribution, therefore, is dedicated in the first place to an effort to establish the textual basis for the Dharmaruci story in Indian sources in Sanskrit, as found in the Divyāvadāna collection, and upon that basis in Kemendra's Bodhisattvāvadānakalpalatā.
Pāinian accounts of the Vedic subjunctive: le Krvaíte
Authors: Scharf Peter M. 
Published: March 2012

AbstractTo determine which Vedic texts Pāini knew requires a comprehensive approach that establishes a high correlation between the complete set of linguistic traits his treatise describes and the complete set of linguistic traits exhibited in each text in question. The examination of individual linguistic traits is inadequate to determine which texts he knew because neither the Vedic nor the grammatical tradition is uniform and static. Bronkhorst (Pāinian Studies: Professor S. D. Joshi Felicitation Volume, p. 75, 1991) calls into question the assumption that Vedic texts were known to Pāini in the form we have received them, while Cardona (Pāinian Studies: Professor S. D. Joshi Felicitation Volume, p. 130, 1991) shows that Pāini's silence concerning certain Vedic forms may be due to deference to certain received exegetical traditions. The current paper considers a case where the Pāinian grammatical tradition entertains disagreement over the derivation of obscure forms. Doubt concerning the recurrence of the term pit (3.4.92) into 3.4.94 brings into question whether Pāini systematically accounts for stem strengthening in the present subjunctive. Kātyāyana, Patañjali, Jayāditya, and Jinendrabuddhi remain silent on the point. Rāmacandra, Śīkria, and Bhaojidīkita assert that pit recurs, thereby allowing stem strengthening. Haradatta, on the other hand, maintains that a rule of indeterminate variation, 3.4.117 chandasy ubhayathā, accounts for it. Nāgeśa points out that the latter procedure is more comprehensive in that it accounts for the lack of stem strengthening in exceptional forms, such as Krvaíte in the Rgveda. The implication is that the former procedure fails to account for the form, which, if Pāini's knowledge of texts were to be established based upon the consideration of individual traits, would imply the absurdity that Pāini, as interpreted by Rāmacandra et al. did not know the Rgveda. On the contrary, however, the procedure of Rāmacandra et al. can employ another rule of indeterminate variation: 3.1.85 vyatyayo bahulam. This procedure, which provides a systematic explanation of the present subjunctive generally and requires a rule of indeterminate variation only to account for exceptional forms, is preferable to leaving the account of stem strengthening in the present subjunctive generally to a rule of indeterminate variatio Since both procedures rely on rules of indeterminate variation to account for the Rgvedic form, however, it is impossible to establish either Pāini's knowledge or ignorance of the text on the basis of his account of the subjunctive. The controversy demonstrates that the depth and variety of the Indian grammatical tradition must be taken into account in determining which rules describe which linguistic facts and that it is inadequate to consider individual traits. A comprehensive approach is required.
REMARKS ON THE NEW EDITION OF THE PAIP PALĀDA-SAHITĀ
Authors: Hoffmann Karl 
Published: March 2012

AbstractThe Paippalāda version of the Atharvaveda existed hitherto, as is generally known, only in a single manuscript originating from Kashmir. It was rendered accessible in an excellent reproduction. Unfortunately the text of this manuscript which is written in Śārada script, is corrupt, in many cases beyond recognition. LeRoy Carr Barret, between the years 1906 and 1940, did the tedious work oftranscribing the Kashmirian manuscript book by book, and added to it his attempts at reconstructing the original wording. It is not Barret's fault that for the most part his efforts and sagacity were doomed to failure, and that rarely convincing results were reached. Nevertheless all scholars who have so far concerned themselves with the Paippalāda version cannot but fully acknowledge and feel grateful for the enormous amount of useful work done by Barret. His edition is distributed in several volumes of the Journal of the American Oriental Society and two independent publications. Thus Raghu Vira's Devanāgarī reproduction of Barret's text, which added some improvements and a specification of parallel passages was very welcome. Yet, inspite of what was achieved by Barret and Raghu Vira, everyone who has dealt with the Paippalāda version from a philological or linguistic point of view has, again and again, been driven to despair. There were only rare cases in which the details inferred from the text could be relied on.
Studien zum śrautaritual II 6. Nigada
Authors: Einoo Shingo 
Published: March 2012

AbstractThis article tries to interpret the word Nigada in a new way. So far Nigada has, on the basis of medieval commentaries, been identified with praia or sampraia, or it has been understood as a term which includes both concepts. As Vedic ritual literature hardly provides an explanation of this word, examples of the use of Nigada have been collected and analysed here. This lead to the conclusion that Nigada is a prose mantra which can be distinguished from sampraia, praia, and nivid. At various occasions during a sacrifice, and because of various reasons, a Nigada is spoken (mostly) by the hot, as an injunction directed to the priests as well as to the deities.
The Contributions of Patrick Colquhoun to Social Theory and Social Philosophy
Authors: Pieris Ralph 
Published: March 2012

AbstractBiographical details of Colquhoun's early life are remarkably scanty. Little is known of his childhood and adolescence. His only formal education was at the local grammar school, where he would have learnt Latin. At the age of sixteen, Colquhoun immigrated to America. During the five years he spent in Virginia, Colquhoun developed an interest in law, political economy, and the social sciences from his legal acquaintances there. In the year of the French Revolution, Colquhoun abandoned the pursuit of commerce and devoted himself to philanthropic and intellectual interests. Colquhoun was far in advance of his time as he argued for the compatibility of social regulation with liberty.
Will Japan Become a Global Power?
Authors: Brown Richard 
Published: March 2012

AbstractMany have argued that Japan will soon emerge as one of the world's greatest powers. During the nineteenth century, Japan had pressed for pre-eminence in Asia and beyond. Does this earlier military expansion and more recent economic dynamism indicate Japan's desire and capacity to play the role of a great power? Japan's regional economic and diplomatic activity, her prominence in such international bodies as the IMF and the World Bank, her status as a leading creditor and technological innovator, all suggest that she does. Just as Britain and the United States created and dominated international systems when they were leading creditors, perhaps Japan in its turn will become a global power.
The Interpretation of μαλιστα In 1 Timothy 5:17
Authors: Kim Hong Bom 
Published: March 2012

AbstractThe word μαλιστα in 1 Tim. 5:17 is traditionally translated into "especially", while contemporary scholars tend to translate it into "in other words". This new translation is based upon Skeat's hypothesis. However, his arguments are not convincing. If we apply the hypothesis to the verse, it is difficult to answer why the author gives directions about the πρεσβυτεροι who rule well without mentioning the πρεσβυτεροι who rule. Ruling is one thing and teaching is another. Skeat himself does not think μαλιστα is used with the meaning here. No support can be found for him in BAGD or LSJ.
Incense Revisited: Reviewing the Evidence for Incense as a Clue to the Christian Provenance of The Greek Life of Adam and Eve
Authors: Smit Peter-Ben 
Published: March 2012

AbstractIn her well-documented article "The Aromatic Fragrances of Paradise in the Greek Life of Adam and Eve and the Christian Origin of the Composition," NovT 46 (2004) 20-45, Rivka Nir offered a fresh interpretation of references to incense and other aromatic substances in the Greek Life of Adam and Eve arguing that these are clearly indicative of its Christian origins. The present contribution reviews Nir's evidence for her conclusions, and argues in the opposite direction, suggesting that this evidence is not always as relevant as Nir assumes and can therefore not be the basis for the kind of conclusions Nir draws.
Mononchid nematodes from oak forests in Bulgaria. 1. The subfamily Anatonchinae Jairajpuri, 1969 with descriptions of Anatonchus genovi sp. n. and Tigronchoides quercus sp. n.
Authors: Peneva Vlada , Neilson Roy , Nedelchev Sevdan 
Published: March 2012

AbstractTwo new and three known species of the family Anatonchidae associated with Quercus spp. in Bulgaria are described and illustrated. Anatonchus genovi n. sp. can be distinguished by the medium size of body (L = 2.5-3.2 mm) and buccal capsule (65- 70 47-59 mum), posterior dorsal tooth, tail short (170-251 mum; c = 13-17; c = 3.1-4.4), elongate conical, narrowly rounded, and cuticle very finely striated at tail tip. Tigronchoides quercus n. sp. is distinguished by females: body 2.5-2.9 mm long, buccal capsule measuring 51-58 43-48 mum, tail 198-267 mum long; males: body 2.1-2.6 mm long, buccal capsule measuring 42-48 29-38 mum, tail 161-204 mum long, ventrally curved, gradually tapering to a long almost cylindrical part with rounded tip; buccal capsule clearly transversely striated and cuticle on tail finely annulated in both sexes. Tigronchoides quercus sp. n. most closely resembles T. istvani and T. ginglymodontus. Morphological data for T. ginglymodontus, Anatonchus tridentatus and A. hortensis are presented. Comments on tooth development for Anatonchinae species with known juvenile stages are provided. Nematodes Mononchides provenant d'une foret de chenes de Bulgarie. 1. La sous-famille des Anatonchinae Jairajpuri, 1969, avec description d'Anatonchus genovi sp. n. et de Tigronchoides quercus sp. n. - Trois especes deja connues et deux nouvelles appartenant a la famille des Anatonchidae et associees a Quercus spp. en Bulgarie sont decrites et illustrees. Anatonchus genovi n. sp. se distingue par la taille moyenne du corps (L = 2,5-3,2 mm) et de la capsule buccale (65-70 47-59 mum), la dent dorsale posterieure, la queue courte (170-251 mum; c = 13-17; c = 3,1-4,4) allongee-conique, etroitement arrondie a l'extremite dont la cuticule est finement striee. Tigronchoides quercus n. sp. se distingue par i) les femelles longues de 2,5-2,9 mm, la capsule buccale mesurant 51-59 43-48 mum, la queue longue de 198-267 mum; ii) les males longs de 2,1-2,6 mm, ayant une capsule buccale mesurant 42-48 29-38 mum, une queue longue de 161-204 mum, courbee ventralement, s'amincissant graduellement jusqu'a une longue partie subcylindrique a extremite arrondie; iii) chez les deux sexes, la capsule buccale finement striee transversalement et la cuticule caudale portant de fines stries. Tigronchoides quercus sp. n. ressemble etroitement a T. istvani et T. ginglymodontus. Des donnees sont fournies sur la morphologie de T. ginglymodontus, Anatonchus tridentatus et A. hortensis. Le developpement de la dent chez les especes d'Anatonchinae dont les stades juveniles sont connus est egalement commente.
After Adorno: Art, Autonomy, and Critique
Authors: Roberts John 
Published: March 2012

AbstractIn conversation with two artist friends recently, both declared that Adorno was a far more serious and productive guide to their practices than any other philosopher or aesthetician. Given their work and histories as artists – one had lived through the period of conceptual art and had been won over briefly to its arguments, the other had emerged out of its ruins — this was a surprise. Like many artists in the late 1970s and early 1980s, both had fallen under the sway of Walter Benjamin, and were convinced, in their respective ways, that the dissolution of the category of Art into the forms of modern technology and everyday life was a good thing. Indeed, both artists were proselytisers for photography and its powers of social reference and communality. Discussions of art's autonomy were not on their checklist of priorities. In fact, if autonomy was discussed or thought of at all, it was denounced as a bourgeois category. Autonomy was what Clement Greenberg and modernist painters believed in, and the bane of all materialist art criticism. It was not what serious post-conceptualist artists, armed with the ‘critique of representation’ and theories of the social production of art, should be worrying about.
The Amarna Royal Women As Images Of Fertility: Perspectives on a Royal Cult
Authors: Stevens Anna 
Published: March 2012

AbstractThis paper is ostensibly an investigation of whether royal women of the Amarna period in Egypt were perceived as figures who could be supplicated for divine assistance in matters of personal fertility. Concurrently, it forms an exercise in approaching the blurred horizon between state and private religion in an Amarna period context. It offers the inclusion of female royalty in private fertility cults as an illustration of the flexibility inherent in the Amarna royal cult, a result of its transposition onto, and interaction with, the private religious landscape of the Eighteenth Dynasty.