bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcranial focused ultrasound to the posterior cingulate cortex modulates default mode network and subjective experience: an fMRI pilot study
Authors: Lord Brian , Sanguinetti Joseph L. , Ruiz Lisannette , Miskovic Vladimir , Segre Joel , Young Shinzen , Fini Maria E. , Allen John J. B. 
Published: June 2024

BackgroundTranscranial focused ultrasound (TFUS) is an emerging neuromodulation tool for temporarily altering brain activity and probing network functioning. The effects of TFUS on the default mode network (DMN) are unknown.ObjectiveThe study examined the effects of transcranial focused ultrasound (TFUS) on the functional connectivity of the default mode network (DMN), specifically by targeting the posterior cingulate cortex (PCC). Additionally, we investigated the subjective effects of TFUS on mood, mindfulness, and self-related processing.MethodsThe study employed a randomized, single-blind design involving 30 healthy subjects. Participants were randomly assigned to either the active TFUS group or the sham TFUS group. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were conducted before and after the TFUS application. To measure subjective effects, the Toronto Mindfulness Scale, the Visual Analog Mood Scale, and the Amsterdam Resting State Questionnaire were administered at baseline and 30 min after sonication. The Self Scale and an unstructured interview were also administered 30 min after sonication.ResultsThe active TFUS group exhibited significant reductions in functional connectivity along the midline of the DMN, while the sham TFUS group showed no changes. The active TFUS group demonstrated increased state mindfulness, reduced Global Vigor, and temporary alterations in the sense of ego, sense of time, and recollection of memories. The sham TFUS group showed an increase in state mindfulness, too, with no other subjective effects.ConclusionsTFUS targeted at the PCC can alter DMN connectivity and cause changes in subjective experience. These findings support the potential of TFUS to serve both as a research tool and as a potential therapeutic intervention.
Independent association between prostate-specific antigen nadir and PSA progression-free survival in first-line abiraterone acetate treatment in castration-resistant prostate cancer patients: a pilot study
Authors: Du Hong , Xie Wenjuan , Chen Wenqiang , Wang Yu , Liao Yong , Qiu Mingxing , Li Jun 
Published: June 2024

BackgroundThere is limited evidence regarding the correlation between prostate-specific antigen (PSA) kinetics and clinical outcomes. Therefore, after regulating other covariates, we studied patients with castration-resistant prostate cancer who received abiraterone acetate as the first-line treatment. In this study, we investigated whether time to PSA nadir was independently associated with PSA progression-free survival (PFS).MethodsAs a retrospective cohort study, this study contained a total of 77 castration-resistant prostate cancer patients who received abiraterone acetate from October 2015 to April 2021 in a Chinese hospital. The dependent variable was PSA-PFS. The objective independent variable was time to PSA nadir (TTPN). Covariates involved in this study included age, duration of androgen deprivation therapy (ADT), PSA level at baseline, time of 50% PSA decline, time of PSA decline to nadir, Gleason score, bone metastasis, previous treatment, PSA decline &lt;50% in 3 months, PSA to nadir in 3 months, PSA decline &lt;90%, PSA decline &lt;0.2 ng/mL, and PSA flare.ResultsFor the 77 subjects, their mean age was 72.70 ± 8.08 years. Fully calibrated linear regression findings indicated that PSA decline and kinetics were positively associated with PFS (months) after adjusting confounders (β = 0.77, 95% CI: 0.11–1.44). A non-linear relationship was not detected between PSA decline or PSA kinetics and progression-free survival.ConclusionAccording to the data of this study, there was a correlation between early PSA changes and patients treated with abiraterone acetate.
A bibliometric and visualization analysis of research trends and hotspots on targeted therapy for breast cancer from 2003 to 2022
Authors: Wu Deqi , Pan Chi , Hu Yangying , Shi Zhijie , Zhou Yankun , Xiao Min 
Published: June 2024

BackgroundBreast cancer is a significant public health issue, exhibiting the most pronounced occurrence and fatality rates among malignant neoplasms globally. Targeted therapy is a medical intervention that focuses on specific molecular markers. This study aims to investigate and evaluate the current research trends and directions in the field of targeted therapy for breast cancer using bibliometric analysis.MethodThe Web of Science database was utilized to retrieve relevant articles published between 2003 and 2022. The VOSviewer software and Bibliometrix package in the R language were employed to conduct co-occurrence and clustering analyses of authors, countries, institutions, journals, references, and the CiteSpace tool was utilized for keyword burst detection.ResultsA total of 2,258 articles were included and the annual number of publications increased rapidly. The most prolific country on this topic was the USA (n=898, 39.77%) and the University of Texas MD Anderson Cancer Center published most papers (n=93). Dennis J. Slamon and Gabriel N. Hortobagyi stood out in the field, with Dennis J. Slamon leading in terms of co-citations(n=653) and Gabriel N. Hortobagyi topping the list in terms of published articles(n=18). The most productive journal was Breast Cancer Research and Treatment and the most cited journal was Journal of Clinical Oncology. The clustering of keywords indicated that the primary focus of researches in the past two decades was on the development and clinical evaluation of tumor-targeted drugs associated with the epidermal growth factor receptor (EGFR) family signaling pathway, and explored mechanisms related to biological behavior of breast cancer. Keywords co-occurrence and burst analysis identified current research hotspots and potential research trends.ConclusionThis study employed bibliometric analysis to examine research on targeted therapy for breast cancer over a span of 20 years, and identified development trends of research and elucidated potential research trajectories in the domain of this topic. This study helps in the identification of prospective collaborators and partner institutions for researchers.
Concomitant use of renin-angiotensin system inhibitors augments the efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis
Authors: Yu Junjie , Meng Fangang , Sui Wenxia , Yu Junmin , Shen Jinhai 
Published: June 2024

BackgroundThe impact of renin-angiotensin system inhibitors (RASIs) on the outcome of hypertensive cancer patients undergoing immune checkpoint inhibitor (ICIs) therapy remains ambiguous. This investigation sought to elucidate the consequences of RASIs use on the prognosis for this specific patient group within the context of ICIs treatment, aspiring to provide a clearer basis for rational, evidence-driven choices in the clinical prescription of these medications.MethodsA comprehensive search was conducted on PubMed, Embase, Web of Science, and the Cochrane Library for original studies published up to 6 August 2023. Studies published in English reporting hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) and/or progression-free survival (PFS) were included. All statistical analyses were executed utilizing R software (version 4.2.2).ResultsA total of 13 studies, encompassing approximately 12,595 patients, satisfied the inclusion criteria. Meta-analyses demonstrated a statistically significant association between the use of RASIs and a favorable outcome in OS (HR, 0.74; 95% CI, 0.62–0.88) and PFS (HR, 0.77; 95% CI, 0.62–0.96) among cancer patients receiving ICIs treatment.ConclusionThis investigation provides compelling evidence supporting the beneficial prognostic impact of RASIs on cancer patients receiving ICIs. RASIs present a viable option as antihypertensive agents for cancer patients with hypertension undergoing ICIs treatment. Further exploration and validation through prospective studies are necessary to establish definitive guidelines for the use of RASIs in managing hypertensive cancer patients undergoing immunotherapy with ICIs.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023454886.
Case report: EGFR-TKI rechallenge after osimertinib-induced interstitial lung disease: a case report and literature review
Authors: Gu Xiaofei , Zhong Yonghong , Huang Huaqiong 
Published: June 2024

BackgroundOsimertinib, a third-generation tyrosine kinase inhibitor (TKI), has demonstrated significant efficacy in treating non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations. However, EGFR-TKI-induced interstitial lung disease (ILD), a well-known adverse effect, can seriously affect the treatment outcome. There is currently no international consensus on the efficacy and safety of re-administration of EGFR-TKI after EGFR-TKI-induced ILD.Case summaryWe report a case of a 62-year-old male with stage IV lung adenocarcinoma and EGFR L858R mutation who was treated with osimertinib at a dose of 80 mg/day as first-line therapy. On the sixth day of treatment, the patient developed grade 4 ILD, chest tightness, shortness of breath, and paroxysmal dry cough. Arterial blood gas analysis indicated the presence of type I respiratory failure, while the chest CT scan revealed newly developed ground-glass opacities in both lungs and a considerable amount of pleural effusion on the left side. Subsequently, the patient was administered methylprednisolone for anti-inflammatory therapy, in conjunction with oxygen therapy, anti-infection treatment, and closed thoracic drainage, which resulted in a favourable recovery and discharge after 18 days. During this period, the patient adhered to third-generation EGFR-TKI oral targeted therapy. Nevertheless, within a week of discharge, the patient was readmitted due to the recurrence of chest tightness and shortness of breath. A chest CT scan indicated a recurrent ILD. Despite the administration of high-dose methylprednisolone for 9 days, the patient’s condition continued to deteriorate, ultimately resulting in death.ConclusionIt is of the utmost importance to conduct a meticulous evaluation of the severity of osimertinib-induced ILD in order to ascertain the potential risks and benefits of EGFR-TKI rechallenge. Particularly, for patients with grade 4 ILD, firm drug discontinuation should be considered.
Precrop-treated soil influences wheat (Triticum aestivum L.) root system architecture and its response to drought
Authors: Cope Jonathan E. , Berckx Fede , Galinski Anna , Lentz Jonas , Nagel Kerstin A. , Fiorani Fabio , Weih Martin 
Published: June 2024

AimsRoot system architecture (RSA) plays an important role in the plant’s ability to sustain yield under abiotic stresses such as drought. Preceding crops (precrops) can affect the yield of the proceeding crop, partially by affecting the RSA. This experiment aims to explore the interactions between precrop identity, crop genotype and drought at early growth stages.MethodsRhizotrons, sized 60 × 80 × 3.5 cm, were used to assess the early root growth of two winter wheat (Triticum aestivum L.) genotypes, using precrop-treated soil around the seedlings and differing water regimes. The rhizotrons were automatically imaged 3 times a week to track root development.ResultsPrecrop-treated soil affected the RSA and changes caused by the reduced water treatment (RWT) were different depending on the precrop. Largest of these was the 36% reduction in root depth after wheat, but 44% after OSR. This indicates that effects caused by the precrop can be simulated, at least partially, by transferring precrop-treated soils to controlled environments. The genotypes had differential RSA and reacted differently to the RWT, with Julius maintaining an 8.8-13.1% deeper root system compared to Brons in the RWT. In addition, the combined environmental treatment affected the genotypes differently.ConclusionOur results could help explain discrepancies found from using precrops to enhance yield as they indicate differences in the preceding crop effect when experiencing drought stress. Further, these differences are affected by genotypic interactions, which can be used to select and adapt crop genotypes for specific crop rotations, depending on the year. Additionally, we have shown a viable method of stimulating a partial precrop effect at the seedling stage in a controlled greenhouse setting using field soil around the germinated seed.
The experience of effort in ADHD: a scoping review
Authors: Wagner Danika , Mason Samantha G. , Eastwood John D. 
Published: June 2024

BackgroundMental effort plays a critical role in regulating cognition. However, the experience of mental effort may differ for individuals with Attention-Deficit/Hyperactivity Disorder (ADHD), a disorder for which sustained mental effort ‘avoidance’ or ‘dislike’ is a criterion in the DSM. We conducted a scoping review to characterize the literature on the experiences of effort in ADHD.MethodsThis systematic scoping review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Extension for Scoping Reviews and Joanna Briggs Methodology. PsycINFO (OVID), PsycINFO (ProQuest) and PubMed were searched for studies published in English before February 14, 2023. Studies must have included an ADHD population or a measure of ADHD symptomatology, in addition to a self-report measure of the experience of effort or the use of an effort preference paradigm. Two researchers reviewed all abstracts, and one researcher reviewed full-text articles.ResultsOnly 12 studies met the inclusion criteria. Several gaps and inconsistencies in the research were identified in terms of method, definitions of effort, measurements of ADHD, and sample characteristics. Moreover, the pattern of results on the experience of effort was mixed.ConclusionDespite its diagnostic and conceptual significance, the experience of mental effort in ADHD is not well studied. Critical gaps were identified in the existing literature. A three-facet conceptualization of effort is proposed–specifically, task-elicited effort, volitionally exerted effort, and the affect associated with engaging in effort – to guide future explorations of the experience of effort in ADHD.
Expanding access to veterinary clinical decision support in resource-limited settings: a scoping review of clinical decision support tools in medicine and antimicrobial stewardship
Authors: Yusuf Havan , Hillman Alison , Stegeman Jan Arend , Cameron Angus , Badger Skye 
Published: June 2024

IntroductionDigital clinical decision support (CDS) tools are of growing importance in supporting healthcare professionals in understanding complex clinical problems and arriving at decisions that improve patient outcomes. CDS tools are also increasingly used to improve antimicrobial stewardship (AMS) practices in healthcare settings. However, far fewer CDS tools are available in lowerand middle-income countries (LMICs) and in animal health settings, where their use in improving diagnostic and treatment decision-making is likely to have the greatest impact. The aim of this study was to evaluate digital CDS tools designed as a direct aid to support diagnosis and/or treatment decisionmaking, by reviewing their scope, functions, methodologies, and quality. Recommendations for the development of veterinary CDS tools in LMICs are then provided.MethodsThe review considered studies and reports published between January 2017 and October 2023 in the English language in peer-reviewed and gray literature.ResultsA total of 41 studies and reports detailing CDS tools were included in the final review, with 35 CDS tools designed for human healthcare settings and six tools for animal healthcare settings. Of the tools reviewed, the majority were deployed in high-income countries (80.5%). Support for AMS programs was a feature in 12 (29.3%) of the tools, with 10 tools in human healthcare settings. The capabilities of the CDS tools varied when reviewed against the GUIDES checklist.DiscussionWe recommend a methodological approach for the development of veterinary CDS tools in LMICs predicated on securing sufficient and sustainable funding. Employing a multidisciplinary development team is an important first step. Developing standalone CDS tools using Bayesian algorithms based on local expert knowledge will provide users with rapid and reliable access to quality guidance on diagnoses and treatments. Such tools are likely to contribute to improved disease management on farms and reduce inappropriate antimicrobial use, thus supporting AMS practices in areas of high need.
Effectiveness of animal-assisted activities and therapies for autism spectrum disorder: a systematic review and meta-analysis
Authors: Xiao Ningkun , Bagayi Vaishnavi , Yang Dandan , Huang Xinlin , Zhong Lei , Kiselev Sergey , Bolkov Mikhail A. , Tuzankina Irina A. , Chereshnev Valery A. 
Published: June 2024

BackgroundGiven the rising interest in complementary therapeutic strategies for autism spectrum disorder (ASD), this research aims to provide a comprehensive analysis of the impact of animal-assisted activities and therapies (AAAT) on various ASD symptoms.MethodsA meticulous search of databases, including Scopus and PubMed, was conducted to gather relevant research on AAAT for ASD. This process led to the selection of 45 studies encompassing 1,212 participants. The chosen studies were then subjected to a meta-analysis to evaluate the efficacy of AAAT in alleviating core ASD symptoms.ResultsThe meta-analysis revealed significant improvements in several core ASD symptoms due to AAAT. Notably, there were improvements in social communication (MD = −4.96, 95% CI [−7.49, −2.44]), irritability (MD = −2.38, 95% CI [−4.06, −0.71]), hyperactivity (MD = −4.03, 95% CI [−6.17, −1.89]), and different word usage skills (MD = 20.48, 95% CI [7.41, 33.55]). However, social awareness (MD = −1.63, 95% CI [−4.07, 0.81]), social cognition (MD = −3.60, 95% CI [−9.36, 2.17]), social mannerisms (MD = −0.73, 95% CI [−2.55, 1.09]), social motivation (MD = −1.21, 95% CI [−2.56, 0.13]), lethargy (MD = −1.12, 95% CI [−3.92, 1.68]), and stereotypical behaviors (MD = −0.23, 95% CI [−1.27, 0.80]) did not significantly improve.ConclusionThe study demonstrates the potential of AAAT in improving certain core symptoms of ASD, such as social communication, irritability, hyperactivity, and word usage skills. However, the effectiveness of AAAT in other ASD symptom domains remains uncertain. The research is limited by the absence of long-term follow-up data and a high risk of bias in existing studies. Therefore, while the findings indicate the promise of AAAT in specific areas, caution is advised in generalizing its efficacy across all ASD symptoms.
СТУДЕНТСЬКЕ НАУКОВЕ ОБ’ЄДНАННЯ: ПРІОРИТЕТИ ТА ПЕРСПЕКТИВИ
Authors: Галицька Олена 
Published: June 2024

У статті проаналізовано діяльність студентської наукової проблемної групи «Тонкощі дискурсу в сучасному європейському освітньому просторі» (керівник – О. Галицька), яка є добровільним об’єднанням здобувачів вищої освіти першого (бакалаврського) рівня та функціонує на кафедрі німецької філології ВНУ імені Лесі Українки. Основною метою діяльності студентської наукової проблемної групи є розвиток у членів та членкинь наукового мислення, критичного аналізу та методологічних навичок. Пріоритетним завданням для керівника студентської наукової проблемної групи є створення сприятливого середовища для обміну ідеями та співпраці між здобувачами вищої освіти різних кафедр, факультетів та спеціальностей. Участь у студентській науковій проблемній групі відкриває можливості для здобувачів вищої освіти публікувати свої дослідження в наукових журналах та брати участь у студентських конференціях. Діяльність студентської наукової проблемної групи «Тонкощі дискурсу в сучасному європейському освітньому просторі» створює стимулюючий науковий контекст для здобувачів вищої освіти, сприяє їхньому особистому та академічному зростанню, а також формуванню активної інтелектуальної спільноти у ВНУ імені Лесі Українки. Основні перспективи студентської наукової проблемної групи «Тонкощі дискурсу в сучасному європейському освітньому просторі» зводяться до посилення міжвузівської взаємодії, розвитку грантової політики, залучення нових учасників і координації діяльності діючих учасників студентської наукової проблемної групи, підвищення мотивації здобувачів освіти до участі в науковій діяльності, розширення зв’язків між науковими групами нашого університету; у здатності залучати фінансові ресурси, гранти, що допоможе забезпечити сталість функціонування студентської наукової проблемної групита реалізацію її наукових ініціатив.
РОЗВИТОК ЧИТАЦЬКОЇ ГРАМОТНОСТІ СТУДЕНТІВ НЕМОВНИХ СПЕЦІАЛЬНОСТЕЙ НА МАТЕРІАЛІ ПРОФЕСІЙНО-ОРІЄНТОВАНИХ ІНШОМОВНИХ ТЕКСТІВ
Authors: Місечко Ольга 
Published: June 2024

Стаття порушує проблему розвитку читацької грамотності при вивченні іноземної мови на неспеціальних факультетах вищої школи України. Як виявили результати міжнародного оцінювання учнів PISA 2022, саме у галузі читання українські школярі мають найбільше відставання від інших 80 тестованих країн. Метою статті є окреслити сутність сучасного розуміння читацької грамотності за міжнародними стандартами і розглянути можливості її розвитку в процесі професійно-орієнтованого вивчення іноземної мови на немовних факультетах вищої школи, потенційними абітурієнтами яких незабаром будуть протестовані школярі. Автори тлумачать поняття «читацька грамотність» ширше, аніж лише сприйняття й розуміння писемного тексту, розглядаючи його у площині рефлексійного мислення, опрацювання структурно-смислового аспекту інформації, суб’єктизоване через особистий досвід, знання й переконання читача. На основі міжнародних стандартизованих рівнів читацької грамотності складена таблиця, де систематизовано характер текстових матеріалів, когнітивні дії з цими матеріалами та загальний контекст їх опрацювання на кожному з 6 рівнів. Аргументується доцільність виокремлення додаткових методичних засад розвитку читацької грамотності, до яких віднесено принцип текстового різноманіття при навчанні іншомовного читання, принцип використання читацьких стратегій, принцип критичності мислення при опрацюванні текстових матеріалів.