bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laser therapy for treating cleft lip or/and palate scarring—a systematic review and meta-analysis
Authors: Sun Yixin , Li Ziming , Qi Xiaoyu , Wang Binghan , Yu Nanze , Huang Jiuzuo , Ting Wenyun , Long Xiao 
Published: June 2024

Abstract
This review aims to assess the efficacy and safety of laser therapy in managing scars resulting from cleft lip and/or palate (CL/P) repair surgeries, as well as to determine the optimal timing for intervention. A systematic search was conducted across four databases using a predefined search strategy. Studies included were randomized controlled trials, non-randomized studies, and case series focusing on laser therapy for CL/P scars. Data extraction and analysis were performed using Revman Software. A total of two randomized controlled trials, four non-randomized studies, and three case series were included in the analysis. The fractional CO2 laser was the most commonly utilized type of laser. Following laser therapy, there was a significant decrease in Vancouver Scar Scale (VSS) scores by 4.05 (95% CI, 2.10–5.99). Meta-analysis revealed that laser treatment groups exhibited a significantly lower mean VSS score (1.3; 95% CI, 0.02–2.67) compared to control groups. Moreover, initiating laser therapy intervention at one month postoperatively resulted in a significantly lower VSS score compared to initiation at three months postoperatively (difference of 1.70; 95% CI, 1.33–2.08). No severe complications were reported. Laser therapy demonstrates effectiveness and safety in improving CL/P scars, with earlier intervention yielding greater benefits.
Trajectory Tracking Control of Fixed-Wing Hybrid Aerial Underwater Vehicle Subject to Wind and Wave Disturbances
Authors: Li Junping , Jin Yufei , Hu Rui , Bai Yulin , Lu Di , Zeng Zheng , Lian Lian 
Published: June 2024

AbstractThe hybrid aerial underwater vehicle (HAUV) could operate in the air and underwater might provide a great convenience for aerial and underwater exploration, and the fixed-wing HAUV (FHAUV) has time, space and cost advantages in future large-scale applications, while the large difference between the aerial and underwater environments is a challenge to control, especially in the air/water transition. However, for FHAUV control, there is a lack of research on phenomena or problems caused by large changes in the air/water transition. In addition, the effects of wind, wave, other factors and conditions on motion control are not investigated. This paper presents the first control study on the above issues. The motion model of FHAUV is developed, with the effects of wind and wave disturbances. Then, this paper improves a cascade gain scheduling (CGS) PID for different media environments (air and water) and proposes a cascade state feedback (CSF) control strategy to address the convergence problem of FHAUV control caused by large speed change in the air/water transition. In the comparisons of the two control schemes in various tracking cases including trajectory slopes, reference speeds, wind and wave disturbances, CSF has a better control effect, convergence rate and robustness; the key factors and conditions of the air/water transition are investigated, the critical relations and feasible domains of the trajectory slopes and reference speeds that the FHAUV must meet to successfully exit the water and enter the air are obtained, the critical slope decreases as the reference speed increases, and the feasible domain of CSF is larger than that of CGS, revealing that CSF is superior than CGS for exiting the water.
The digital operational resilience act: challenges and some reflections on the adequacy of Europe’s architecture for financial supervision
Authors: Buttigieg Christopher P. , Zimmermann Beatriz Brunelli 
Published: June 2024

AbstractThe paper critically analyses the Digital Operational Resilience Act (DORA) within the European Union (EU) with respect to challenges such as supervision and the oversight framework coordination. It delves into the adequacy of the European System of Financial Supervision (ESFS) in ensuring compliance with this regulation, highlighting issues of fragmented supervision at national level and inconsistent approaches. The main argument suggests that while the DORA Regulation is a positive step for harmonising digital operational resilience regulation, it brings about challenges in supervisory convergence and cooperation due to the existing fragmented supervisory architecture. The authors propose potential solutions like a more centralised supervision model to address these challenges. The paper follows a structured format with an overview of the DORA Regulation, discussion on identified challenges, and a concluding section.
Human Microglia–Like Cells Differentiated from Monocytes with GM-CSF and IL-34 Show Phagocytosis of α-Synuclein Aggregates and C/EBPβ-Dependent Proinflammatory Activation
Authors: Llaves-López Andrea , Micoli Elia , Belmonte-Mateos Carla , Aguilar Gerard , Alba Clara , Marsal Anais , Pulido-Salgado Marta , Rabaneda-Lombarte Neus , Solà Carme , Serratosa Joan , Vidal-Taboada Jose M. , Saura Josep 
Published: June 2024

AbstractMicroglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using rodent microglial cultures. To understand the role of microglia in human disease, reliable in vitro models of human microglia are necessary. Monocyte-derived microglia-like cells (MDMi) are a promising approach. This study aimed to characterize MDMi cells generated from adult human monocytes using granulocyte–macrophage colony-stimulating factor and interleukin-34. To this end, 49 independent cultures of MDMI were prepared, and various methodological and functional studies were performed. We show that with this protocol, adult human monocytes develop into microglia-like cells, a coating is unnecessary, and high cell density seeding is preferable. When compared to monocytes, MDMi upregulate the expression of many, but not all, microglial markers, indicating that, although these cells display a microglia-like phenotype, they cannot be considered bona fide human microglia. At the functional level, MDMi phagocytose α-synuclein aggregates and responds to lipopolysaccharide (LPS) by nuclear translocation of the transcription factor nuclear factor-kappaB (NFkappaB) and the upregulation of proinflammatory genes. Finally, a long-lasting silencing of the transcription factor CCAAT/enhancer protein β (C/EBPβ) was achieved by small interfering RNA, resulting in the subsequent downregulation of proinflammatory genes. This supports the hypothesis that C/EBPβ plays a key role in proinflammatory gene program activation in human microglia. Altogether, this study sheds new light on the properties of MDMi cells and supports these cells as a promising in vitro model for studying adult human microglia–like cells.
Mapping the Behavioral Signatures of Shank3b Mice in Both Sexes
Authors: Liu Jingjing , Ye Jialin , Ji Chunyuan , Ren Wenting , He Youwei , Xu Fuqiang , Wang Feng 
Published: June 2024

AbstractAutism spectrum disorders (ASD) are characterized by social and repetitive abnormalities. Although the ASD mouse model with Shank3b mutations is widely used in ASD research, the behavioral phenotype of this model has not been fully elucidated. Here, a 3D-motion capture system and linear discriminant analysis were used to comprehensively record and analyze the behavioral patterns of male and female Shank3b mutant mice. It was found that both sexes replicated the core and accompanied symptoms of ASD, with significant sex differences. Further, Shank3b heterozygous knockout mice exhibited distinct autistic behaviors, that were significantly different from those those observed in the wild type and homozygous knockout groups. Our findings provide evidence for the inclusion of both sexes and experimental approaches to efficiently characterize heterozygous transgenic models, which are more clinically relevant in autistic studies.
Principles of EU law in climate litigation
Authors: Colombo Esmeralda 
Published: June 2024

AbstractThe present contribution questions the role of principles of EU law in climate litigation. Notwithstanding their importance within the EU general regulatory framework, their operationalisation in climate litigation is underexplored. To appreciate EU principles in the context of climate change litigation, this paper positions them within the scope and dynamics of climate change litigation worldwide. Secondly, with this background, the analysis develops as a case law review on the emerging role of the precautionary principle, intergenerational equity, and the minimum harmonisation principle in the climate litigation. To date, five relevant climate lawsuits have unfolded before the courts of EU Member States, which allows for canvassing the content, status, and significance of the principles under examination with concrete examples of the climate lawsuits where these principles have been applied. In this regard, the paper finds that courts in Member States have steadily provided protection of the climate and future generations through rights-based arguments supported by principles. In this context, domestic courts seem to be filling the normative gap left by the CJEU by interpreting fundamental rights in relation to EU environmental principles in what I conceptualise as “the rights turn through principles.” As a final point, the paper concludes with the prospective development of EU principles in the EU legal order and beyond, possibly enabling comparisons with other jurisdictions.
Bisexual Discrimination, Internalized Binegativity and their Impact on Mental Health
Authors: Velasco Judith , Miranda-Tena Andrea , Sanmartín Francisco J. 
Published: June 2024

Abstract
Introduction
Bisexual individuals experience discrimination both from heterosexual individuals and from the Lesbian and Gay (LG) community. This double discrimination affects their mental health. This study aimed to explore the relationship between binegativity (from heterosexual and LB individuals) and internalized binegativity and symptoms of depression and anxiety, as well as the mediating role of social support. The second purpose was to explore whether these variables could predict the symptoms of depression and anxiety.

Methods
A sample of 110 bisexual individuals (77.3% cisgender women, Mage = 25.2) completed self-report measures.

Results
Most participants reported being discriminated against by heterosexual (93.2%) and LG (81.8%) individuals. However, they perceived and experienced higher discrimination from heterosexual people. The majority experienced internalized binegativity. As hypothesized, heterosexual discrimination predicted depressive and anxiety symptoms. Contrary to expectations, discrimination from the LG community and internalized binegativity did not predict symptoms, although bivariate correlations showed a positive relationship. Social support was a moderator of symptoms of depression, but not of anxiety.

Conclusions
These findings highlight the impact of binegativity on the mental health of bisexual individuals and the importance of social support.

Policy implications
Our results provide practitioners and policymakers with evidence of the effects of discrimination experienced by bisexual individuals. Educational campaigns and public awareness programs are needed to foster a more inclusive and accepting society.
Classification of Diffusion Constants of Transmitter and Receiver and Distance Between Them Using Mobile Molecular Communication via Diffusion Model
Authors: Er Mehmet Bilal , Isik Ibrahim , Kuran Umut , Isik Esme 
Published: June 2024

AbstractMolecular communication (MC) holds promise for enabling communication in scenarios where traditional wireless methods may be impractical or ineffective, offering unique capabilities for a range of applications in both natural and engineered systems. In this research, a novel approach to MC is explored, diverging from the standard use of stationary transmitter and receiver models typically found in the field. The study introduces a dynamic MC model, where both the transmitter and receiver are mobile within a diffusion environment. This model operates using a 5-bit system. The key finding is that the mobility of these nanodevices alters their distance, which in turn impacts the likelihood of molecule reception at the receiver. The study employs deep learning techniques, specifically a combination of Convolutional Neural Networks (CNN) and Long Short-Term Memory (LSTM) networks, to categorize the mobility patterns of the receiver (Rx) and transmitter (Tx). By analyzing various mobility rates (Drx and Dtx) and distances between the Tx and Rx, the research successfully identifies the most efficient mobile MC model in terms of molecule reception rates. The use of Linear Support Vector Machine alongside the CNN and LSTM hybrid feature vector resulted in an 87.68% accuracy in predicting diffusion coefficients. Moreover, using a Cubic Support Vector with the same hybrid feature vector, the study achieved an 88.09% accuracy in estimating the distance between the transmitter and receiver. The study concludes that an increase in the mobilities of Rx and Tx correlates with a higher rate of molecule reception.
The confluence of attitudes towards mathematics and pedagogical practice: evaluating the use of mathematical manipulatives
Authors: Quane Kate 
Published: June 2024

AbstractThe use of manipulatives to develop conceptual understanding is a prevalent practice in many mathematical learning experiences, particularly in the early years of schooling. From primary student perspectives, our understanding of the impact of manipulatives in mathematics education on students’ attitudes is limited. This study evaluates the impact of mathematical manipulatives on Young Children’s Attitudes Towards Mathematics (YCATM) by examining children’s drawings, as well as their written and verbal descriptions of their drawings from 106 year 2 and year 3 students. Classroom observations were conducted to investigate how attitudes towards mathematics are enacted during mathematical learning experiences. The modified three-dimensional model of attitude (MTMA) and Bruner’s experiential stages were used to investigate how manipulatives influence YCATM. Data analyses used systematic, numerical coding, and thematic and comparative approaches, employing inductive, deductive, and anticipatory coding for data from both lesson and non-lesson contexts. The findings suggest that young children enjoyed using manipulatives, contributing to their vision of mathematics and perceived competence. However, the transition between enactive, iconic, and symbolic experiences can contribute to the formation of negative attitudes. The present study also emphasizes the importance of context, content, and familiarity with the use of manipulatives.
On Darboux theorems for geometric structures induced by closed forms
Authors: Gràcia Xavier , de Lucas Javier , Rivas Xavier , Román-Roy Narciso 
Published: June 2024

AbstractThis work reviews the classical Darboux theorem for symplectic, presymplectic, and cosymplectic manifolds (which are used to describe mechanical systems), as well as certain cases of multisymplectic manifolds, while extends the Darboux theorem in new ways to k-symplectic and k-cosymplectic manifolds (all these structures appear in the geometric formulation of first-order classical field theories). Moreover, we discuss the existence of Darboux theorems for classes of precosymplectic, k-presymplectic, k-precosymplectic, and premultisymplectic manifolds, which are the geometrical structures underlying some kinds of singular field theories, i.e. with locally non-invertible Legendre maps. Approaches to Darboux theorems based on flat connections associated with geometric structures are given, while new results on polarisations for (k-)(pre)(co)symplectic structures arise.
Parthenium hysterophorus-derived iron-coated biochar: a sustainable solution for nitrate and phosphate removal from water
Authors: islam Izaz ul , Ahmad Mushtaq , Shah Behzad , Ahmad Hafiz Muhammad , Janiad Sara , Shah Nasrullah , Yabalak Erdal 
Published: June 2024

AbstractWater bodies face severe pollution from industrial operations and other human activities, endangering biotic life worldwide. Nitrate and phosphate contamination poses a significant challenge globally. This study focuses on developing an efficient adsorbent, derived from Parthenium hysterophorus (P. hysterophorus), for nitrate and phosphate removal from water. Biochar, termed P. hysterophorus stem biochar (SBC), was prepared at 650℃ and further coated with iron, creating iron-coated stem biochar (ICSBC), to enhance adsorption potential. SEM, TEM, EDX, and FTIR analyses characterized raw and coated biochars. Comparative adsorption studies revealed that P. hysterophorus ICSBC exhibited high adsorption capacity (nitrate = N = 77.17 mg/g, phosphate = P = 83.93 mg/g) and removal efficiency (nitrate = 88.19%, phosphate = 95.89%). Batch experiments explored the effects of contact time, adsorbent loading, pH, and initial concentration. Kinetic and equilibrium models demonstrated that the pseudo-second-order kinetic and Langmuir isotherm models best fit the data (R2 values: N = 0.9644, P = 0.98122, N = 93.68, P = 92.97, respectively). ICSBC’s favorable attributes, including strong adsorption, low cost, and eco-friendliness, position it as an ideal adsorbent for nitrate and phosphate removal from contaminated water.
Graphical abstract
A review of soil pollution by potentially toxic elements and remediation strategies in copper mining areas in Iran
Authors: Rouhani A. , Hejcman M. , Trögl J. 
Published: June 2024

AbstractWith a substantial rise in both domestic and worldwide copper mining rates over the past decade, Iran has become a major producer of copper in the Middle East. The increasing need for copper-based products in a variety of industries, including as information technology, electronics, transportation, and construction, is driving this rise. However, the expansion of copper mining activities has led to environmental degradation, particularly in mining sites where potentially hazardous elements (PTEs) have contaminated the soil. Despite these significant environmental impacts, they have often been overlooked, posing long-term environmental challenges as copper extraction continues. This research extensively reviews the literature (from 2000 to 2023) on soil contamination in Iran’s copper mining districts, focusing on PTEs. It evaluates the extent of potentially hazardous elements’ pollution in soils, comparing findings with global data, and explores remediation strategies employed in these regions. Results suggest that studies predominantly center around the Sarcheshmeh copper mine, highlighting copper, lead, and molybdenum as dominant PTE pollutants. Phytoremediation emerges as the primary remediation method used in these areas, indicating Iran's sustainable approach to addressing potentially hazardous elements’ contamination. This review recommends comprehensive monitoring of PTEs across all Iranian copper mines and further exploration of native plant species that successfully grow and stabilize potentially hazardous elements grow in copper mining areas remediation.
Vitamin D and Toxic Metals in Pregnancy - a Biological Perspective
Authors: Fisher Mandy , Weiler Hope A. , Kuiper Jordan R. , Borghese Michael , Buckley Jessie P. , Shutt Robin , Ashley-Martin Jillian , Subramanian Anita , Arbuckle Tye E. , Potter Beth K. , Little Julian , Morisset Anne-Sophie , Jukic Anne Marie 
Published: June 2024

Abstract
Purpose of Review
To discuss the potential biological mechanisms between vitamin D and toxic metals and summarize epidemiological studies examining this association in pregnant women.

Recent Findings
We identified four plausible mechanisms whereby vitamin D and toxic metals may interact: nephrotoxicity, intestinal absorption of metals, endocrine disruption, and oxidative stress. Few studies have examined the association between vitamin D and toxic metals in pregnant women. North American studies suggest that higher vitamin D status early in pregnancy are associated with lower blood metals later in pregnancy. However, a trial of vitamin D supplementation in a pregnant population, with higher metal exposures and lower overall nutritional status, does not corroborate these findings.

Summary
Given ubiquitous exposure to many toxic metals, nutritional intervention could be a means for prevention of adverse outcomes. Future prospective studies are needed to establish a causal relationship and clarify the directionality of vitamin D and metals.
Risk of Anaphylaxis Associated with Cold Urticaria
Authors: Bizjak Mojca , Rutkowski Krzysztof , Asero Riccardo 
Published: June 2024

Abstract
Purpose of review
Cold-induced anaphylaxis (ColdA) is a poorly understood form of anaphylaxis that occurs in patients with cold urticaria (ColdU). This comprehensive review aims to deepen the understanding of ColdA. It emphasizes the identification of high-risk ColdU patients susceptible to ColdA and provides recommendations for their effective management.

Recent findings
Recent studies, including the large international COLD-CE study, have identified clinical features of ColdU patients associated with increased ColdA risk. These individuals can now be recognized through routine clinical assessments. Key diagnostic indicators for assessing ColdU and the risk of ColdA include oropharyngeal/laryngeal symptoms and positive standard local cold provocation tests. ColdA has been defined as acute cold-induced involvement of the skin and/or visible mucosal tissue accompanied by cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms, but a universally accepted definition is lacking. Additionally, ColdA has recently been recognized as an indication for prescribing adrenaline (epinephrine) autoinjectors, marking a significant advancement in disease management.

Summary
ColdA is a major and potentially life-threatening concern for a subset of ColdU patients. Early recognition of high-risk patients, coupled with education and preparedness of both patients and healthcare providers, is crucial for effectively managing this challenging condition. Further research is needed to expand understanding of the underlying pathophysiological mechanisms of ColdA, identify potential cofactors influencing ColdA, and improve disease-management strategies.