bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orbital dynamics in the GG Tau A system: Investigating its enigmatic disc
Authors: Toci Claudia , Ceppi Simone , Cuello Nicolás , Duchêne Gaspard , Ragusa Enrico , Lodato Giuseppe , Farina Francesca , Ménard François , Aly Hossam 
Published: June 2024

Context. GG Tau is one of the most studied young multiple stellar systems: GG Tau A is a hierarchical triple surrounded by a massive disc and its companion, GG Tau B, is also a binary. Despite numerous observational attempts, a comprehensive understanding of the geometry of the GG Tau A system is still elusive. Given the significant role of dynamical interactions in shaping the evolution of these systems, it is relevant to characterise the stellar orbits and the discs’ properties.
Aims. To determine the best orbital configuration of the GG Tau A system and its circumtriple disc, we provide new astrometric measures of the system and we run a set of hydrodynamical simulations with two representative orbits to test how they impact a disc composed of dust and gas.
Methods. We tested the dynamical evolution of the two scenarios on short and long timescales. We obtained synthetic flux emission from our simulations at different timescales and we compared them with multi-wavelength observations of 1300 µm ALMA dust continuum emission and 1.67 µm SPHERE dust scattering to infer the most likely orbital arrangement.
Results. We extend the analysis of the binary orbital parameters using six new epochs from archival data, showing that the current measurements alone (and future observations coming in the next 5–10 yr) are not capable of fully breaking the degeneracy between families of coplanar and misaligned orbits, but finding that a modest misalignment is probable. We find that the timescale for the onset of the disc eccentricity growth, τecc, is a fundamental timescale for the morphology of the system. Results from the numerical simulations obtained using the representative coplanar and misaligned (∆θ = 30°) orbits show that the best match between the position of the stars, the cavity size, and the dust ring size of GG Tau A is obtained with the misaligned configuration on timescales shorter than τecc. The results exhibit an almost circular cavity and dust ring, favouring slightly misaligned (∆θ ~ 10–30°) low-eccentricity (e ~ 0.2–0.4) orbits. However, for both scenarios, the cavity size and its eccentricity quickly grow for timescales longer than τecc and the models do not reproduce the observed morphology anymore. This implies that either the age of the system is shorter than τecc or that the disc eccentricity growth is not triggered or dissipated in the system. This finding raises questions about the future evolution of the GG Tau A system and, more generally, the time evolution of eccentric binaries and their circumbinary discs.
High-cadence monitoring of the emission properties of magnetar XTE J1810−197 with the Stockert radio telescope
Authors: Bause Marlon L. , Herrmann Wolfgang , Spitler Laura G. 
Published: June 2024

Context. Since the detection of a burst resembling a fast radio burst (FRB) from the Galactic magnetar SGR 1935+2154, magnetars have joined the set of favourable candidates for FRB progenitors. However, the emission mechanism of magnetars remains poorly understood.
Aims. Observations of magnetars with a high cadence over extended timescales have allowed for their emission properties to be determined, in particular, their temporal variations. In this work, we present the results of the long-term monitoring campaign of the magnetar XTE J1810−197 since its second observed active phase from December 2018 until November 2021, with the Stockert 25 m radio telescope.
Methods. We present a single pulse search method, improving on commonly used neural network classifiers thanks to the filtering of radio frequency interference based on its spectral variance and the magnetar’s rotation.
Results. With this approach, we were able to lower the signal to noise ratio (S/N) detection threshold from 8 to 5. This allowed us to find over 115 000 spiky single pulses – compared to 56 000 from the neutral network approach. Here, we present the temporal variation of the overall profile and single pulses. Two distinct phases of different single pulse activity can be identified: phase 1 from December 2018 to mid-2019, with a few single pulses per hour, and phase 2 from September 2020 with hundreds of single pulses per hour (with a comparable average flux density). We find that the single pulse properties and folded profile in phase 2 exhibit a change around mid-March 2021. Before this date, the folded profile consists of a single peak and single pulses, with fluences of up to 1000 Jyms and a single-peaked width distribution at around 10 ms. After mid-March 2021, the profile consists of a two peaks and the single pulse population shows a bimodal width distribution with a second peak at 1 ms and fluences of up to 500 Jyms. We also present asymmetries in the phase-resolved single pulse width distributions beginning to appear in 2020, where the pulses arriving earlier in the rotational phase appear wider than those appearing later. This asymmetry persists despite the temporal evolution of the other single pulse and emission properties.
Conclusions. We argue that a drift in the emission region in the magnetosphere may explain this observed behaviour. Additionally, we find that the fluence of the detected single pulses depends on the rotational phase and the highest fluence is found in the centre of the peaks in the profile. While the majority of the emission can be linked to the detected single pulses, we cannot exclude another weak mode of emission. In contrast to the pulses from SGR 1935+2154, we have not found any spectral feature or bursts with energies in the order of magnitude of an FRB during our observational campaign. Therefore, the question of whether this magnetar is capable of emitting such highly energetic bursts remains open.
Update zu COVID-19 und Impfungen gegen respiratorische Erreger bei entzündlich-rheumatischen Erkrankungen
Authors: Hasseli-Fräbel Rebecca 
Published: June 2024

ZUSAMMENFASSUNGDerzeit steigen die Zahlen der Atemwegserkrankungen in der Wintersaison wieder deutlich an. Trotz des Endes der Pandemie spielt COVID-19 (Coronavirus-Infektion 2019) weiterhin eine wichtige Rolle. Vor allem Menschen ab dem 60. Lebensjahr haben weiterhin ein erhöhtes Risiko, einen schweren COVID-19-Verlauf zu entwickeln. Etwa 33 % der COVID-19-Fälle mussten seit der 40. Kalenderwoche 2023 stationär behandelt werden. Basierend auf der Entwicklung der SARS-CoV-2-Infektion und der Virusvarianten wird seit Januar 2024 eine jährliche Auffrischimpfung gegen COVID-19 mit den adaptierten Impfstoffen für Personen mit entsprechendem Risikoprofil empfohlen. Darüber hinaus soll erneut auf die Anwendung von Schutzmaßnahmen insbesondere in der Wintersaison zur Reduzierung des Infektionsrisikos hingewiesen werden. Für die antivirale Therapie stehen bei erhöhtem Risiko für schwere COVID-19-Verläufe Nirmatrelvir/Ritonavir und Remdesivir zur Verfügung. Neben COVID-19 spielen Influenza-, Pneumokokken- und Respiratory-Syncytial-Virus-Infektionen eine wichtige Rolle. Auch hier kann eine Impfprävention schwere Infektionsverläufe verhindern.
Wie impfe ich im Alter bzw. bei anderen Risikogruppen und sollte man den Impferfolg kontrollieren?
Authors: Krasselt Marco 
Published: June 2024

ZUSAMMENFASSUNGImpfungen leisten einen unschätzbaren Beitrag zur Verhinderung von Infektionen und reduzieren damit die Mortalität, insbesondere im Alter. Die erfolgreichen Impfkampagnen während der COVID-19-Pandemie haben diese Tatsache eindrücklich unterstrichen. Die Alterung des Immunsystems (Immunoseneszenz) einerseits und die Zunahme von Komorbiditäten andererseits begünstigen mit zunehmendem Alter Infektionen. Die Immunoseneszenz führt darüber hinaus zu einer eingeschränkten Impfantwort. Infektiologische Erkrankungen des Respirationstraktes – wie eine Pneumokokken-Pneumonie oder Influenza – spielen mit fortschreitendem Alter eine besondere Rolle. Bei der Pneumokokken-Pneumonie betrifft die Mortalität beispielsweise fast ausschließlich ältere Menschen. In jüngster Vergangenheit finden auch Infektionen mit dem Respiratory Syncytial Virus (RSV) zunehmend Beachtung, erste Empfehlungen hierzu gibt es von der Sächsischen Impfkommission. Auch wenn eine Kontrolle des Impferfolges im klinischen Alltag verlockend erscheint und manchmal auch aktiv nachgefragt wird, besteht hierzu selten eine Indikation. Dies begründet sich u. a. dadurch, dass häufig gar keine serologischen Schutzkorrelate bekannt sind und die Interpretation der Befunde damit schwierig ist. Die Serologie sollte besonderen Situationen (z. B. Immunsuppression) vorbehalten bleiben.
Reaktanz: Missing Link der Bewegungsförderung?
Authors: Huber Gerhard 
Published: June 2024

ZusammenfassungEs besteht eine große Diskrepanz zwischen dem Wissen um den gesundheitlichen Wert
der körperlichen Aktivität und der tatsächlichen Umsetzung in der Bevölkerung.
Dies gilt in besonderer Ausprägung für das von uns untersuchte Personal in der
stationären Altersversorgung. Der sozialpsychologische Ansatz der Reaktanz und
die die dazugehörige Theorie hilft uns, dieses Phänomen besser zu verstehen. In
dem Beitrag wird dieses Konzept kurz erläutert und seine Bedeutung für die
Bewegungsförderung vor dem Hintergrund der Erfahrungen im Modellvorhaben POLKA
dargestellt.
Grußwort
Authors: Storm Andreas 
Published: June 2024

Sehr geehrte Leserinnen und Leser,die Stärkung der Pflege bleibt insbesondere nach der Pandemie eine der großen
Herausforderungen für unsere Gesellschaft: Das Personal ist erschöpft und leidet
mehr denn je unter dem Personalmangel. Der demografische Wandel verschärft die
Situation weiter: Einer wachsenden Zahl Pflegebedürftiger steht eine stetig
abnehmende Zahl an Nachwuchskräften gegenüber.
Duodenal Atresia in Finland from 2004 to 2017: Prevalence, Mortality, and Associated Anomalies—A Population-Based Study
Authors: Alikärri Suvi , Helenius Ilkka , Heiskanen Susanna , Syvänen Johanna , Kemppainen Teemu , Löyttyniemi Eliisa , Gissler Mika , Raitio Arimatias 
Published: June 2024

Abstract
Introduction Duodenal atresia (DA) is the most common atresia of the small bowel. This study aims to assess the prevalence, mortality, and associated anomalies related to DA in Finland from 2004 to 2017.
Material and Methods A nationwide study based on registers maintained by the Finnish Institute for Health and Welfare and Statistics Finland containing data on all live births and stillbirths and terminations of pregnancy. The cases were identified based on the ICD-9 and 10 (International Classification of Diseases revisions 9 and 10) codes. Associated anomalies were classified based on the EUROCAT criteria; minor anomalies were excluded.
Results There were 249 DA cases including 222 (89.2%) live births, 16 (6.4%) stillbirths, and 11 (4.4%) terminations. There was no significant change in the prevalence rates between 2004 and 2017. Live birth prevalence was 2.75/10,000 and total prevalence was 3.08/10,000 births. A total of 100 (40.2%) cases were isolated, 67 (26.9%) had other multiple congenital anomalies, and 83 (33.3%) were syndromic. There were no terminations in isolated DA. Most associated anomalies were cardiac (36.1%), followed by other gastrointestinal tract anomalies (23.7%) and limb deformities/defects (7.2%). Trisomy 21 was observed in 63 cases (25.3%). Neonatal mortality was 3.6% (n = 8) and at 1 year 95.0% were alive. Both neonatal and infant mortalities were associated with cardiac anomalies (p < 0.001 and p = 0.001, respectively). All neonatal deaths had associated cardiac defect(s).
Conclusions The prevalence of DA in Finland remains stable and among the highest reported. DA is often associated with cardiac anomalies, which portend a high risk for mortality. Despite the burden of associated anomalies, overall survival is high.
Is a 3 mm Surgical Margin Safe for Basal Cell Carcinoma in the Head and Neck that is Less than 2 cm, Considering Different Risk Factors?
Authors: Yong Min-Jun , Yoo Seok-Ju , Shin Hea-Kyeong 
Published: June 2024

Abstract
Background Basal cell carcinoma (BCC) is the most common type of nonmelanoma skin cancer. Typically, resection requires a safety margin of ≥4 mm. When removing tumor cells, achieving complete excision with minimal safety margins and reconstructing the defect to preserve the original appearance are important. In this study, we used a 3-mm resection margin to confirm recurrence and re-resection rates.
Methods Electronic medical records and photographic data were obtained for patients with primary BCC lesions less than 2 cm in diameter who underwent wide excision with a 3-mm surgical margin from January 2015 to November 2021. We analyzed factors determining recurrence and re-resection rates, such as tumor size, location, age, sex, underlying diseases (including immunosuppression state), ethnicity, subtypes, tumor borders, etc.
Results This study included 205 patients. The mean age and follow-up period were 73.0 ± 11.5 years and 10.2 ± 8.0 months, respectively. The recurrence and re-resection rates were 1.95% and 25.85%, respectively.A statistically significant correlation was found between recurrence rate and tumor border (p = 0.013) and the re-resection rate was correlated statistically with location (p = 0.022) and immunosuppressed patients (p = 0.006).
Conclusion We found that a 3-mm excision margin provided sufficient safety in small facial BCC, resulting in ease of surgery and better aesthetic outcomes.However, surgical margins must be determined case by case by integrating various patient factors. In particular, a surgical margin of ≥4 mm is required for BCC in high-risk areas, immunosuppressed patients, or poorly defined border.
Tandem Diboration–Protoboration of Terminal Alkynes: A Practical Route to α-Substituted Alkenyl Boronates
Authors: Morken James P. , Kong Ziyin , Park Jimin , Fei Muchun , Warfield Josephine , Wang Dunwei 
Published: June 2024

AbstractA practical method is introduced for the catalytic conversion of terminal alkynes into α-substituted vinyl boronic esters. The process employs catalytic amounts of nanoparticle-supported gold catalysts and catalytic amounts of copper to effect the overall transformation.
Diagnostic Accuracy of Somatosensory Evoked Potential and Transcranial Motor Evoked Potential in Detection of Neurological Injury in Intradural Extramedullary Spinal Cord Tumor Surgeries: A Short-Term Follow-Up Prospective Interventional Study Experience from Tertiary Care Center of India
Authors: Mishra Manish Kumar , Pandey Nityanand , Sharma Hanjabam Barun , Prasad Ravi Shankar , Sahu Anurag , Pradhan Ravi Shekhar , Yadav Vikrant 
Published: June 2024

Abstract
Objective Intraoperative neuromonitoring (IONM) is an acknowledged tool for real-time neuraxis assessment during surgery. Somatosensory evoked potential (SSEP) and transcranial motor evoked potential (MEP) are commonest deployed modalities of IONM. Role of SSEP and MEP in intradural extramedullary spinal cord tumor (IDEMSCT) surgery is not well established. The aim of this study was to evaluate sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of SSEP and transcranial MEP, in detection of intraoperative neurological injury in IDEMSCT patients as well as their postoperative limb-specific neurological improvement assessment at fixed intervals till 30 days.
Materials and Methods Symptomatic patients with IDEMSCTs were selected according to the inclusion criteria of study protocol. On modified McCormick (mMC) scale, their sensory-motor deficit was assessed both preoperatively and postoperatively. Surgery was done under SSEP and MEP (transcranial) monitoring using appropriate anesthetic agents. Gross total/subtotal resection of tumor was achieved as per IONM warning alarms. Sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of SSEP and MEP were calculated considering postoperative neurological changes as “reference standard.” Patients were followed up at postoperative day (POD) 0, 1, 7, and 30 for convalescence.
Statistical Analysis With appropriate tests of significance, statistical analysis was carried out. Receiver-operating characteristic curve was used to find cutoff point of mMC for SSEP being recordable in patients with higher neurological deficit along with calculation of sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of SSEP and MEP for prediction of intraoperative neurological injury.
Results Study included 32 patients. Baseline mean mMC value was 2.59. Under neuromonitoring, gross total resection of IDEMSCT was achieved in 87.5% patients. SSEP was recordable in subset of patients with mMC value less than or equal to 2 with diagnostic accuracy of 100%. MEP was recordable in all patients and it had 96.88% diagnostic accuracy. Statistically significant neurological improvement was noted at POD-7 and POD-30 follow-up.
Conclusion SSEP and MEP individually carry high diagnostic accuracy in detection of intraoperative neurological injuries in patients undergoing IDEMSCT surgery. MEP continues to monitor the neuraxis, even in those subsets of patients where SSEP fails to record.
The Prevalence of the Middle Clinoid Process: A Cross-Sectional Comparative Study in Patients with and without Pathology of the Sella Turcica
Authors: Anukulsampan Suppaluk , Tansirisithikul Chottiwat , Sitthinamsuwan Bunpot 
Published: June 2024

Abstract
Background The middle clinoid process (MCP), particularly caroticoclinoid ring (CCR) type of the MCP, is an important part of the sphenoid bone for skull base surgery. Previous studies have shown a wide range of MCP prevalence affected by various factors. However, no study has investigated the association between the MCP and the presence of sellar lesions.
Objectives The main aim of this study was to evaluate the prevalence of the MCP in the Thai population and factors associated with its presence.
Materials and Methods We conducted a cross-sectional study on 400 sides from 200 patients (100 with and 100 without sellar lesions) using cranial computerized tomography scans. Demographic data and MCP characteristics were collected. The association between individual variables and the presence of the MCP was determined by univariate and multivariate analysis.
Results The MCP was identified in 168 of 400 sides (42%). Patients with sellar lesions had a significantly lower prevalence of the MCP compared with normal controls (29.5% versus 54.5%, p < 0.001). Of all MCP only 6% were the CCR type. Univariate and multivariate analysis showed that the absence of the sellar lesion was the only factor significantly associated with presence of the MCP (odds ratio: 2.86; 95% confidence interval: 1.90–4.32; p< 0.001).
Conclusion The prevalence of the MCP was relatively high in the Thai population, while the prevalence of the CCR was relatively low compared with previous studies. The absence of sellar lesions was the only factor associated with the presence of the MCP.
Use of Ambient Light Compatible Fluorescence-Guided Surgical Technology for Objective Assessment of Flap Perfusion in Autologous Breast Reconstruction
Authors: Shaffrey Ellen C. , Moura Steven P. , Seitz Allison J. , Jupitz Sydney , Seets Trevor , Kawahara Tisha , Uselmann Adam , Lin Christie , Poore Samuel O. 
Published: June 2024

Abstract
Background Decreased autologous flap vascular perfusion can lead to secondary procedures. Fluorescence angiography during surgery reduces the probability of repeat surgery but suffers from interpretation variability. Recently, the OnLume Avata System was developed, which evaluates real-time vascular perfusion in ambient light. This study aims to predict complications in autologous breast reconstruction using measures of relative intensity (RI) and relative area (RA).
Methods Patients undergoing autologous breast reconstruction underwent intraoperative tissue perfusion assessment using the OnLume Avata System. Post-hoc image annotation was completed by labeling areas of the flap interpreted to be “Well Perfused,” “Questionably Perfused,” and “Under Perfused.” RIs and RAs were calculated for the marked areas. Primary complications of interest were overall complication rate, fat and mastectomy skin flap necrosis, and surgical revision. Logistic regression was applied to determine the odds of developing a complication based on RI and RA for each image.
Results A total of 25 patients (45 flaps) were included. In total, 17 patients (68%) developed at least one complication. Patients who developed any complication (p = 0.02) or underwent a surgical revision for complications (p = 0.02) had statistically lower RI of under-perfused portions of the flap. Patients with greater areas of under-perfused flap had a significantly higher risk of developing fat necrosis (odds ratio [OR]: 5.71, p = 0.03) and required a revision operation (OR: 1.10, p = 0.01).
Conclusion Image-based interpretation using the OnLume Avata System correlated with the risk of developing postoperative complications that standard fluorescence imaging systems may not appreciate. This information can benefit surgeons to improve perfusion assessment and intraoperative decision-making.
“Flap-in-Flap” Technique: Double V-Y Flap in Fingertip Injury Management
Authors: Jayachandiran Anand Prasath , Rajendran Suresh , Ananthappan Manoj , Mahipathy Surya Rao Rao Venkata , Durairaj Alagar Raja 
Published: June 2024

Abstract
Background Fingertip injuries with amputation are one of the common hand injury problems. Several reconstructive options are available for fingertip injury. V-Y advancement flap is one of the common flaps. In some cases, their advancement capacities are not sufficient to cover the whole defect, resulting in flexion deformity of the distal interphalangeal (DIP) joint, loss of finger pulp shape, or hooked deformity. The double V-Y flap consists of harvesting two cutaneous flaps on the same neurovascular digital palmar bundle. The first V-Y flap is raised as a neurovascular flap and the second flap is an advancement V-Y plasty.
Objective This article evaluates the outcomes of the double V-Y advancement flap for the fingertip reconstruction.
Materials and Methods This is a prospective study on 19 patients with zone II and III fingertip amputation tip defects between December 2021 and June 2023. The majority were workplace injuries.
Results There were 16 males and 3 females. The average static two-point discrimination was 6 mm. Average advancement of first flap is 8.5 mm and the average advancement of second flap is 4.3 mm. The average total advancement of a double V-Y flap is 12.94 mm (10–15 mm). All of them had “good” total active motion with movement > 210. One patient had flexion deformity at the DIP joint without causing any functional disturbance. All the flaps settled well except for one patient who had superficial partial necrosis of flap which was managed conservatively.
Conclusion This is simple and safe for the reconstruction of zone II and III fingertip amputations with the advantage of like-for-like tissue with near-normal sensation. The second flap increased the advancement of the proximal flap, restoring the pulp shape, and thereby reconstructing a functional and aesthetic fingertip.