bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: 1‐Alkynyl‐ and 1‐Alkenyl‐3‐arylimidazo[1,5‐a]pyridines: Synthesis, Photophysical Properties, and Observation of a Linear Correlation Between the Fluorescent Wavelength and Hammett Substituent Constants.
Authors: Yamaguchi Eiji , Shibahara Fumitoshi , Murai Toshiaki 
Published: November 2011

AbstractA number of title compounds is prepared which all exhibit fluorescence in solution.
ChemInform Abstract: Synthesis of Imidazo[1,2‐a]pyridines by the Bis(acetyloxy)(phenyl)‐λ3‐iodane Mediated Oxidative Coupling of 2‐Aminopyridines with β‐Keto Esters and 1,3‐Diones.
Authors: Wang Xianpei , Ma Lijuan , Yu Wei 
Published: November 2011

AbstractOptimized conditions are evaluated for the title process which is applied to the preparation of various biologically important heterocyclic scaffolds.
ChemInform Abstract: Synthesis of Antitrypanosomal 1,2‐Dioxane Derivatives Based on a Natural Product Scaffold.
Authors: Holla Harish , Labaied Mehdi , Pham Ngoc , Jenkins Ian D. , Stuart Kenneth , Quinn Ronald J. 
Published: November 2011

AbstractThe new scaffold (IV), based on antitrypanosomal and antimalarial compounds isolated from different Plakortis species, contains a peroxide unit which is stable to chemical manipulation elsewhere in the molecule.
ChemInform Abstract: Hydrazine‐Hydroquinone Complex as an Efficient Solid Phase Hydrazine Donor: High Yield Synthesis of Luminol and Isoluminol.
Authors: Chattopadhyay Gautam , Ray Partha Sinha 
Published: November 2011

AbstractA simple solid phase synthesis of luminol (IV), isoluminol (VI) and related chemiluminescent compounds (X) is presented.
ChemInform Abstract: Synthesis of an Aryloxy Oxo Pyrimidinone Library that Displays ALK‐Selective Inhibition.
Authors: Slavish P. Jake , Price Jeanine E. , Jiang Qin , Cui Xiaoli , Morris Stephan W. , Webb Thomas R. 
Published: November 2011

AbstractSome of the synthesized compounds exhibit single digit micromolecular inhibition of ALK in vitro.
ChemInform Abstract: Silica‐Bonded S‐Sulfonic Acid as a Recyclable Catalyst for Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones.
Authors: Niknam Khodabakhsh , Mohammadizadeh Mohammad Reza , Mirzaee Salimeh 
Published: November 2011

AbstractSilica‐bonded S‐sulfonic acid (SBSSA) is prepared in three steps and can be recycled for at least ten times.
ChemInform Abstract: Cationic Palladium‐Catalyzed [5 + 2] Annulation of 2‐Acylmethoxyboronic Acids and Allenoates: Synthesis of 1‐Benzoxepine Derivatives.
Authors: Yu Xufen , Lu Xiyan 
Published: November 2011

AbstractThe formation of naphthoxepines, benzocycloheptanes, and fused 8‐membered O‐heterocycles is not possible.
ChemInform Abstract: Switch in Stereoselectivity Caused by the Isocyanide Structure in the Rhodium‐Catalyzed Silylimination of Alkynes.
Authors: Fukumoto Yoshiya , Hagihara Motoyuki , Kinashi Fuyuko , Chatani Naoto 
Published: November 2011

AbstractReaction of terminal alkynes with isocyanides and hydrosilanes proceeds smoothly in the presence of a Rh catalyst to give, after imine hydrolysis, the β‐silyl‐α,β‐unsaturated aldehydes (IV)/(V).
ChemInform Abstract: Diastereo‐ and Enantioselective Ruthenium‐Catalyzed Hydrohydroxyalkylation of 2‐Silyl‐butadienes: Carbonyl syn‐Crotylation from the Alcohol Oxidation Level.
Authors: Zbieg Jason R. , Moran Joseph , Krische Michael J. 
Published: November 2011

AbstractThe reaction of silylbutadiene (I) with a wide variety of primary alcohols is catalyzed by Ru(II) and SEGPHOS ligands.
ChemInform Abstract: Photoredox Catalyzed C—P Bond Forming Reactions — Visible Light Mediated Oxidative Phosphonylations of Amines.
Authors: Rueping Magnus , Zhu Shaoqun , Koenigs Rene M. 
Published: November 2011

AbstractThe first protocol for an oxidative carbon‐phosphorous bond formation using a photoredox catalysis procedure is described.
ChemInform Abstract: Copper/DIPEA‐Catalyzed, Aldehyde‐Induced Tandem Decarboxylation—Coupling of Natural α‐Amino Acids and Phosphites or Secondary Phosphine Oxides.
Authors: Yang Dongxu , Zhao Depeng , Mao Lijuan , Wang Linqing , Wang Rui 
Published: November 2011

AbstractThe reaction allows a new access to α‐amino phosphonates and phosphine oxides.
ChemInform Abstract: A Protecting‐Group‐Free Route to Chiral BINOL—Phosphoric Acids.
Authors: Li Baojian , Chiu Pauline 
Published: November 2011

AbstractA two‐step, protecting‐group‐free route for the synthesis of 3,3‐disubstituted and 6,6‐disubstituted chiral BINOL—phosphoric acids is realized.
ChemInform Abstract: Three New Megastigmane Glucopyranosides from the Cardamine komarovii.
Authors: Lee Il Kyun , Kim Ki Hyun , Lee Seung Young , Choi Sang Un , Lee Kang Ro 
Published: November 2011

AbstractThe three new compounds, named komaroveside A (I), B (II), and C (III) are isolated together with eight known compounds.
ChemInform Abstract: Nothospondin, a New AP‐1 Inhibitory Quassinoid from the Cameroonian Plant Nothospondias staudtii.
Authors: Diyabalanage Thushara , Ratnayake Ranjala , Wilson Jennifer A. , Henrich Curtis J. , Beutler John A. , Colburn Nancy H. , McMahon James B. , Gustafson Kirk R. 
Published: November 2011

AbstractThe quassinoid, nothospondin (I), is obtained along with the known compound glaucarubinone.
ChemInform Abstract: A Powerful New Construction of Complex Chiral Polycycles by an Indium(III)‐Catalyzed Cationic Cascade.
Authors: Surendra Karavadhi , Qiu Wenwei , Corey E. J. 
Published: November 2011

AbstractInI3‐ and InBr3‐promoted π activation of CC triple bonds initiates cationic cascade reactions of propargylic alcohols or silyl ethers to give polycycles with up to six fused ring systems.
ChemInform Abstract: Fast and Efficient Microwave‐Assisted Synthesis of Functionalized Peptoids via Ugi Reactions.
Authors: Barreto Angelica de Fatima S. , Vercillo Otilie E. , Birkett Mike A. , Caulfield John C. , Wessjohann Ludger A. , Andrade Carlos Kleber Z. 
Published: November 2011

AbstractMicrowave‐assisted four‐component Ugi reaction of isocyanoacetate (I) with Cbz‐glycine (II), paraformaldehyde and a diversity of amines provides an efficient access towards functionalized peptoids (V).
ChemInform Abstract: New Insight on 2‐Naphthylmethyl (NAP) Ether as a Protecting Group in Carbohydrate Synthesis: A Divergent Approach Toward a High‐Mannose Type Oligosaccharide Library.
Authors: Li Yao , Roy Bimalendu , Liu Xinyu 
Published: November 2011

AbstractA new method for the selective cleavage of 2‐naphthylmethyl ether utilizing 10—20 molar excess of HF/Py is revealed and applied to a divergent approach towards the generation of an oligosaccharide library.
ChemInform Abstract: Synthesis of Renieramycins: Construction of the Core Ring System of Cribrostatin 4 Through Modified Pictet—Spengler Cyclization of 3,6‐Bisarylpiperazine‐2,5‐dione with Diethoxyethyl Benzoate.
Authors: Yokoya Masashi , Ito Hiroshi , Saito Naoki 
Published: November 2011

AbstractThe synthesis of the compound (V), which is a key intermediate in the synthesis of cribrostatin 4 can be achieved by a stereoselective cyclization, cf.
ChemInform Abstract: Enantioselective Synthesis of Glutarimide Alkaloids Cordiarimides A, B, Crotonimides A, B, and Julocrotine.
Authors: Teng Bo , Zheng Jianfeng , Huang Huiying , Huang Peiqiang 
Published: November 2011

AbstractFor the confirmation of their structures all alkaloids are synthesized starting from Boc‐L‐glutamine.
ChemInform Abstract: Exploring a Unique Reactivity of 6π‐Azaelectrocyclization to Enzyme Inhibition, Natural Products Synthesis, and Molecular Imaging: An Approach to Chemical Biology by Synthetic Chemists
Authors: Tanaka Katsunori , Fukase Koichi , Katsumura Shigeo 
Published: November 2011

AbstractReview: ca. 100 refs.
Pathways for plasmalemmal repair mediated by PKA, Epac, and cytosolic oxidation in rat B104 cells in vitro and rat sciatic axons ex vivo
Authors: Spaeth Christopher S. , Spaeth Elaine B. , Wilcott Robert W. , Fan Jerry D. , Robison Taylor , Bittner George D. 
Published: November 2011

AbstractPlasmalemmal repair (sealing) is necessary for survival of damaged eukaryotic cells. Ca2+ influx through plasmalemmal disruptions activates pathways that initiate sealing, which is commonly assessed by exclusion of extracellular dye. These sealing pathways include PKA, Epac, and cytosolic oxidation. In this article, we investigate whether PKA, Epac, and/or cytosolic oxidation, activate specific proteins required to produce a plasmalemmal seal. We report that toxin cleavage of proteins required for neurotransmitter release (SNAP‐25), inhibition of Golgi trafficking (with Brefeldin A: Bref A) or inhibition of N‐ethylmaleimide sensitive factor (NSF) all decrease sealing of rat B104 hippocampal cells with transected neuritis in vitro. Epac, but not PKA or cytosolic oxidation, partly overcomes the decrease in sealing produced by cleavage of SNAP‐25. PKA and increased cytosolic oxidation, but not Epac, can partly overcome the decrease in sealing due to Bref A. PKA, Epac, and/or cytosolic oxidation cannot overcome NSF inhibition. Substances that affect plasmalemmal sealing of B104 neurites in vitro have similar effects on plasmalemmal sealing in rat sciatic axons ex vivo. From these and other data, we propose a model of plasmalemmal sealing having three redundant, evolutionarily conserved, parallel pathways that all converge on NSF. © 2011 Wiley Periodicals, Inc. Develop Neurobiol, 2012
Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: Implications for neurodevelopmental disorders
Authors: Schaevitz Laura R. , Picker Jonathan D. , Rana Jasmine , Kolodny Nancy H. , Shane Barry , Berger‐Sweeney Joanne E. , Coyle Joseph T. 
Published: November 2011

AbstractInteractions between genetic and environmental risk factors underlie a number of neuropsychiatric disorders, including schizophrenia (SZ) and autism (AD). Due to the complexity and multitude of the genetic and environmental factors attributed to these disorders, recent research strategies focus on elucidating the common molecular pathways through which these multiple risk factors may function. In this study, we examine the combined effects of a haplo‐insufficiency of glutamate carboxypeptidase II (GCPII) and dietary folic acid deficiency. In addition to serving as a neuropeptidase, GCPII catalyzes the absorption of folate. GCPII and folate depletion interact within the one‐carbon metabolic pathway and/or of modulate the glutamatergic system. Four groups of mice were tested: wild‐type, GCPII hypomorphs, and wild‐types and GCPII hypomorphs both fed a folate deficient diet. Due to sex differences in the prevalence of SZ and AD, both male and female mice were assessed on a number of behavioral tasks including locomotor activity, rotorod, social interaction, prepulse inhibition, and spatial memory. Wild‐type mice of both sexes fed a folic acid deficient diet showed motor coordination impairments and cognitive deficits, while social interactions were decreased only in males. GCPII mutant mice of both sexes also exhibited reduced social propensities. In contrast, all folate‐depleted GCPII hypomorphs performed similarly to untreated wild‐type mice, suggesting that reduced GCPII expression and folate deficiency are mutually protective. Analyses of folate and neurometabolite levels associated with glutamatergic function suggest several potential mechanisms through which GCPII and folate may be interacting to create this protective effect. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 891–905, 2012
Crystal Growth and Structure of the New Ferrimagnetic Oxyphosphate PbFe3O(PO4)3
Authors: El Hafid Hassan , Velázquez Matias , Pérez Olivier , El Jazouli Abdelaziz , Pautrat Alain , Decourt Rodolphe , Veber Philippe , Viraphong Oudomsack , Delmas Claude 
Published: November 2011

AbstractA new oxyphosphate, PbFe3O(PO4)3, has been discovered and its structure has been characterized by single‐crystal XRD between 293 and 973 K (monoclinic, space groupP21/m, a = 7.5826 Å, b = 6.3759 Å, c = 10.4245 Å, β = 99.956°, Z = 2, at r.t.). Direct‐current (DC) magnetic susceptibility and specific heat measurements performed on single crystals revealed an unusual sequence of second‐order ferromagnetic‐like phase transitions at Tc1 = 31.8 K, Tc2 = 23.4 K and Tc3 ≈ 10 K. Alternating‐current (AC) magnetic susceptibility measurements suggest glass‐like dynamics between ca. 20 K and Tc3.
A prototypic system of parallel electrophoresis in multiple capillaries coupled with microwell arrays
Authors: Su Jing , Ren Kangning , Dai Wen , Zhao Yihua , Zhou Jianhua , Wu Hongkai 
Published: November 2011

AbstractWe present a microfluidic system that can be directly coupled with microwell array and perform parallel electrophoresis in multiple capillaries simultaneously. The system is based on an array of glass capillaries, fixed in a polydimethylsiloxane (PDMS) microfluidic scaffold, with one end open for interfacing with microwells. In this capillary array, every two adjacent capillaries act as a pair to be coupled with one microwell; samples in the microwells are introduced and separated by simply applying voltage between two electrodes that are placed at the other ends of capillaries; thus no complicated circuit design is required. We evaluate the performance of this system and perform multiple CE with direct sample introduction from microwell array. Also with this system, we demonstrate the analysis of cellular contents of cells lysed in a microwell array. Our results show that this prototypic system is a promising platform for high‐throughput analysis of samples in microwell arrays.
A simultaneous space sampling method for DNA fraction collection using a comb structure in microfluidic devices
Authors: Li Zheyu , Sun Kai , Sunayama Misato , Araki Ryoko , Ueno Kosei , Abe Masumi , Misawa Hiroaki 
Published: November 2011

AbstractFraction collection of selected components from a complex mixture plays a critical role in biomedical research, environmental analysis, and biotechnology. Here, we introduce a novel electrophoretic chip device based on a signal processing theorem that allows simultaneous space sampling for fractionation of ssDNA target fragments. Ten parallel extraction channels, which covered 1.5‐mm‐long sampling ranges, were used to facilitate the capturing of fast‐moving fragments. Furthermore, the space sampling extraction made it possible to acquire pure collection, even from partly overlapping fragments that had been insufficiently separated after a short electrophoretic run. Fragments of 180, 181, and 182 bases were simultaneously collected, and then the recovered DNA was PCR amplified and assessed by CE analysis. The 181‐base target was shown to be isolated in a 70‐mm‐long separation length within 10 min, in contrast to the >50 min required for the 300‐mm‐long separation channel in our previous study. This method provides effective combination of time and space, which is a breakthrough in the traditional concept of fraction collection on a chip.
Developmental profile of SK2 channel expression and function in CA1 neurons
Authors: Ballesteros‐Merino Carmen , Lin Mike , Wu Wendy W. , Ferrandiz‐Huertas Clotilde , Cabañero María J. , Watanabe Masahiko , Fukazawa Yugo , Shigemoto Ryuichi , Maylie James , Adelman John P. , Luján Rafael 
Published: November 2011

AbstractWe investigated the temporal and spatial expression of SK2 in the developing mouse hippocampus using molecular and biochemical techniques, quantitative immunogold electron microscopy, and electrophysiology. The mRNA encoding SK2 was expressed in the developing and adult hippocampus. Western blotting and immunohistochemistry showed that SK2 protein increased with age. This was accompanied by a shift in subcellular localization. Early in development (P5), SK2 was predominantly localized to the endoplasmic reticulum in the pyramidal cell layer. But by P30 SK2 was almost exclusively expressed in the dendrites and spines. The level of SK2 at the postsynaptic density (PSD) also increased during development. In the adult, SK2 expression on the spine plasma membrane showed a proximal‐to‐distal gradient. Consistent with this redistribution and gradient of SK2, the selective SK channel blocker apamin increased evoked excitatory postsynaptic potentials (EPSPs) only in CA1 pyramidal neurons from mice older than P15. However, the effect of apamin on EPSPs was not different between synapses in proximal or distal stratum radiatum or stratum lacunosum‐moleculare in adult. These results show a developmental increase and gradient in SK2‐containing channel surface expression that underlie their influence on neurotransmission, and that may contribute to increased memory acquisition during early development. © 2011 Wiley Periodicals, Inc.
Oxygen Productivity of Planktonic Algae under Fluctuating and Constant Light Conditions
Authors: Gervais Frank 
Published: November 2011

AbstractNet oxygen productivity in cultures of Monoraphidium minutum, Cryptomonas sp. and Planktothrix agardhii exposed to fluctuating and constant light conditions was measured in a laboratory incubator. The fluctuating light climate simulated a linear up and down movement in a 2 m water column at 4 different ratios of euphotic depth to mixing depth. In addition, cultures were kept at a constant light climate simulating static incubation at 0, 0.5, 1 and 2 m depth and at the depth of the mean irradiance, respectively. Integral productivity in the simulated water column was lowest when algae were incubated at constant light in different depths, highest when the algae were incubated at constant mean photon flux density (PFD) and intermediate under fluctuating light. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
CLAY DISPERSION IN TYPICAL SOILS OF NORTH CAMEROON AS A FUNCTION OF PH AND ELECTROLYTE CONCENTRATION
Authors: Nguetnkam J. P. , Dultz S. 
Published: November 2011

ABSTRACTKnowledge of clay dispersion behaviour [which is highly influenced by ion concentration in the aqueous phase and by related surface charge (SC) of colloids] is important for rating soil erosion risk (by water). It can also be useful for improving soil management systems. Clay fractions separated from samples of the A‐horizon of a Vertisol, Ultisol and Oxisol were collected, representing typical soils of North Cameroon. These soils were very different in physicochemical and mineral parameters. The effect of pH and the multivalent ions Ca2+, SO42− and PO43− on SC and dispersion characteristics were determined. The water dispersible clay was found to be higher in the Vertisol and Ultisol than in the Oxisol, indicating that the <2 µm fractions from the Vertisol and Ultisol are more dispersible than that from the Oxisol. The clay dispersion ratio together with the dispersion ratio were found to be in good agreement with water dispersible clay and are negatively correlated with the amount of organic matter and dithionite citrate bicarbonate soluble Fe and Al. Generally, SC of the <2 µm fraction was found to be negative when the pH was in the region of 3 to 9; thus the absolute value is highly pH‐dependent. At pH 6 and 8, CaCl2, Na2SO4 and Na2HPO4 additions had antagonistic effects on SC: Ca2+ increased SC, whereas SO42− and PO43−decreased SC indicating the adsorption of positively as well as negatively charged multivalent ions by soil colloids. Along with the increase of SC, there was a fall in repulsive forces and formation of Ca‐bridges, the addition of Ca2+ induced flocculation more rapidly than SO42− and PO43− amendments. Copyright © 2011 John Wiley & Sons, Ltd.
Resolution adapted finite element modeling of radio frequency interactions on conductive resonant structures in MRI
Authors: Ruoff Jürgen , Würslin Christian , Graf Hansjörg , Schick Fritz 
Published: November 2011

AbstractPrediction of interactions between the radiofrequency electromagnetic field in magnetic resonance scanners and electrically conductive material surrounded by tissue plays an increasing role for magnetic resonance safety. Testing of conductive implants or instruments is usually performed by standardized experimental setups and temperature measurements at distinct geometrical points, which cannot always reflect worst‐case situations. A finite element method based on Matlab (The Mathworks, Natick, MA) and the finite element method program Comsol Multiphysics (Stockholm, Sweden) with a spatially highly variable mesh size solving Maxwell's full‐wave equations was applied for a comprehensive simulation of the complete geometrical arrangement of typical birdcage radiofrequency coils loaded with small conductive structures in a homogenous medium. Conductive implants like rods of variable length and closed and open ring structures, partly exhibiting electromagnetic resonance behavior, were modeled and evaluated regarding the distribution of the B1‐ and E‐field, induced currents and specific absorption rates. Numerical simulations corresponded well with experiments using a spin‐echo sequence for visualization of marked B1‐field inhomogeneities. Even resonance effects in conductive rods and open rings with suitable geometry were depicted accurately. The proposed method has high potential for complementation or even replacement of common experimental magnetic resonance compatibility measurements. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Reduced complexity sphere decoding
Authors: Li Boyu , Ayanoglu Ender 
Published: November 2011

ABSTRACTIn multiple‐input multiple‐output (MIMO) systems, sphere decoding (SD) can achieve a performance equivalent to a full‐search maximum likelihood decoding, with reduced complexity. Several researchers reported techniques that reduce the complexity of SD further. In this paper, a new technique that decreases the computational complexity of SD substantially, without sacrificing performance, is introduced. The reduction is accomplished by deconstructing the decoding metric to decrease the number of computations and by exploiting the structure of a lattice representation. Furthermore, an application of SD employing a proposed smart implementation with very low computational complexity is introduced. This application calculates the soft bit metrics of a bit‐interleaved convolutional‐coded MIMO system in an efficient manner. On the basis of the reduced complexity SD, the proposed smart implementation employs the initial radius acquired by zero‐forcing decision feedback equalization, which ensures no empty spheres. Other than that, a technique of a particular data structure is also incorporated to efficiently reduce the number of executions carried out by SD. Simulation results show that these approaches achieve substantial gains in terms of the computational complexity for both uncoded and coded MIMO systems. Copyright © 2011 John Wiley & Sons, Ltd.