bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence of hyperuricemia in China: a meta-analysis
Authors: B Liu , T Wang , HN Zhao , WW Yue , HP Yu , CX Liu , J Yin , RY Jia , HW Nie 
Published: October 2011

Abstract

Background
The prevalence of hyperuricemia varied in different populations and it appeared to be increasing in the past decades. Recent studies suggest that hyperuricemia is an independent risk factor for cardiovascular disease. However, there has not yet been a systematic analysis of the prevalence of hyperuricemia in China.

Methods
Epidemiological investigations on hyperuricemia in China published in journals were identified manually and on-line by using CBMDISC, Chongqing VIP database and CNKI database. Those Reported in English journals were identified using MEDLINE database. Selected studies had to describe an original study defined by strict screening and diagnostic criteria. The fixed effects model or random effects model was employed according to statistical test for homogeneity.

Results
Fifty-nine studies were selected, the statistical information of which was collected for systematic analysis. The results showed that the pooled prevalence of hyperuricemia in male was 21.6% (95%CI: 18.9%-24.6%), but it was only 8.6% (95%CI: 8.2%-10.2%) in female. It was found that thirty years was the risk point age in male and it was fifty years in female.

Conclusions
The prevalence of hyperuricemia is different as the period of age and it increases after 30 years in male and 50 in female. Interventions are necessary to change the risk factors before the key age which is 30 years in male and 50 in female.
A fast approach to determine a fed batch feeding profile for recombinant Pichia pastoris strains
Authors: Dietzsch Christian , Spadiut Oliver , Herwig Christoph 
Published: October 2011

Abstract

Background
The microorganism Pichia pastoris is a commonly used microbial host for the expression of recombinant proteins in biotechnology and biopharmaceutical industry. To speed up process development, a fast methodology to determine strain characteristic parameters, which are needed to subsequently set up fed batch feeding profiles, is required.

Results
Here, we show the general applicability of a novel approach to quantify a certain minimal set of bioprocess-relevant parameters, i.e. the adaptation time of the culture to methanol, the specific substrate uptake rate during the adaptation phase and the maximum specific substrate uptake rate, based on fast and easy-to-do batch cultivations with repeated methanol pulses in a batch culture. A detailed analysis of the adaptation of different P. pastoris strains to methanol was conducted and revealed that each strain showed very different characteristics during adaptation, illustrating the need of individual screenings for an optimal parameter definition during this phase. Based on the results obtained in batch cultivations, dynamic feeding profiles based on the specific substrate uptake rate were employed for different P. pastoris strains. In these experiments the maximum specific substrate uptake rate, which had been defined in batch experiments, also represented the upper limit of methanol uptake, underlining the validity of the determined process-relevant parameters and the overall experimental strategy.

Conclusion
In this study, we show that a fast approach to determine a minimal set of strain characteristic parameters based on easy-to-do batch cultivations with methanol pulses is generally applicable for different P. pastoris strains and that dynamic fed batch strategies can be designed on the specific substrate uptake rate without running the risk of methanol accumulation.
Some Coincidence Point Theorems for Nonlinear Contraction in Ordered Metric Spaces
Authors: Shatanawi Wasfi , Mustafa Zead , Tahat Nedal 
Published: October 2011

AbstractWe establish new coincidence point theorems for nonlinear contraction in ordered metric spaces. Also, we introduce an example to support our results. Some applications of our obtained results are given.MSC: 54H25; 47H10; 54E50; 34B15.
Identification of genotype 4 Hepatitis E virus binding proteins on swine liver cells
Authors: Zhang Wen , Hua Xiuguo , Shen Quan , Yang Shixing , Yin Hong , Cui Li 
Published: October 2011

Abstract
Hepatitis E virus (HEV) is a zoonotic pathogen of which several species of animal were reported as reservoirs. Swine stands out as the major reservoir for HEV infection in humans, as suggested by the close genetic relationship of swine and human virus and cross-species infection of HEV. Up to now, the mechanism of cross-species infection of HEV from swine to humans is still unclear. This study sought to identify receptor element for genotype 4 HEV on swine liver cells using the viral overlay protein binding assay (VOPBA) technique and Mass Spectrometry fingerprinting. A single virus binding band with natural molecular weight about 55 kDa was observed, and mass spectrometry revealed that this virus binding band contained 31 different proteins. Infection inhibition assay suggested that this 55 kDa protein could prevent HEV from infecting its susceptible A549 cell line, which was further confirmed by the HEV genome detecting in the inoculated cells. Further research should be performed to elucidate the accurate receptor of HEV on the swine liver cells.
Adult separation anxiety in patients with complicated grief versus healthy control subjects: relationships with lifetime depressive and hypomanic symptoms
Authors: Dell'Osso Liliana , Carmassi Claudia , Corsi Martina , Pergentini Irene , Socci Chiara , Maremmani Angelo GI , Perugi Giulio 
Published: October 2011

Abstract

Background
Around 9% to 20% of bereaved individuals experience symptoms of complicated grief (CG) that are associated with significant distress and impairment. A major issue is whether CG represents a distinctive nosographic entity, independent from other mental disorders, particularly major depression (MD), and the role of symptoms of adult separation anxiety. The purpose of this study was to compare the clinical features of patients with CG versus a sample of healthy control subjects, with particular focus on adult separation anxiety and lifetime mood spectrum symptoms.

Methods
A total of 53 patients with CG and 50 healthy control subjects were consecutively recruited and assessed by means of the Structured Clinical Interview for DSM-IV Axis-I disorders (SCID-I/P), Inventory of Complicated Grief (ICG), Adult Separation Anxiety Questionnaire (ASA-27), Work and Social Adjustment Scale (WSAS) and Mood Spectrum-Self Report (MOODS-SR) lifetime version.

Results
Patients with CG reported significantly higher scores on the MOODS-SR, ASA-27, and WSAS with respect to healthy control subjects. The scores on the ASA-27 were significantly associated with the MOODS-SR depressive and manic components amongst both patients and healthy control subjects, with a stronger association in the latter.

Conclusions
A major limitation of the present study is the small sample size that may reduce the generalizability of the results. Moreover, lifetime MOODS-SR does not provide information about the temporal sequence of the manic or depressive symptoms and the loss. The frequent comorbidity with MD and the association with both depressive and manic lifetime symptoms do not support the independence of CG from mood disorders. In our patients, CG is associated with high levels of separation anxiety in adulthood. However, the presence of lifetime mood instability, as measured by the frequent presence of depressive and hypomanic lifetime symptoms, suggests that cyclothymia might represent the common underlying feature characterizing the vulnerability to both adult separation anxiety and CG.
The genetic validation of heterogeneity in schizophrenia
Authors: Tsutsumi Atsushi , Glatt Stephen J , Kanazawa Tetsufumi , Kawashige Seiya , Uenishi Hiroyuki , Hokyo Akira , Kaneko Takao , Moritani Makiko , Kikuyama Hiroki , Koh Jun , Matsumura Hitoshi , Yoneda Hiroshi 
Published: October 2011

Abstract

Introduction
Schizophrenia is a heritable disorder, however clear genetic architecture has not been detected. To overcome this state of uncertainty, the SZGene database has been established by including all published case-control genetic association studies appearing in peer-reviewed journals. In the current study, we aimed to determine if genetic variants strongly suggested by SZGene are associated with risk of schizophrenia in our case-control samples of Japanese ancestry. In addition, by employing the additive model for aggregating the effect of seven variants, we aimed to verify the genetic heterogeneity of schizophrenia diagnosed by an operative diagnostic manual, the DSM-IV.

Methods
Each positively suggested genetic polymorphism was ranked according to its p-value, then the seven top-ranked variants (p < 0.0005) were selected from DRD2, DRD4, GRIN2B, TPH1, MTHFR, and DTNBP1 (February, 2007). 407 Schizophrenia cases and 384 controls participated in this study. To aggregate the vulnerability of the disorder based on the participants' genetic information, we calculated the "risk-index" by adding the number of genetic risk factors.

Results
No statistically significant deviation between cases and controls was observed in the genetic risk-index derived from all seven variants on the top-ranked polymorphisms. In fact, the average risk-index score in the schizophrenia group (6.5+/-1.57) was slightly lower than among controls (6.6+/-1.39).

Conclusion
The current work illustrates the difficulty in identifying universal and definitive risk-conferring polymorphisms for schizophrenia. Our employed number of samples was small, so we can not preclude the possibility that some or all of these variants are minor risk factors for schizophrenia in the Japanese population. It is also important to aggregate the updated positive variants in the SZGene database when the replication work is conducted.
Xenorhodopsins, an enigmatic new class of microbial rhodopsins horizontally transferred between archaea and bacteria
Authors: Ugalde Juan A , Podell Sheila , Narasingarao Priya , Allen Eric E 
Published: October 2011

Abstract
Based on unique, coherent properties of phylogenetic analysis, key amino acid substitutions and structural modeling, we have identified a new class of unusual microbial rhodopsins related to the Anabaena sensory rhodopsin (ASR) protein, including multiple homologs not previously recognized. We propose the name xenorhodopsin for this class, reflecting a taxonomically diverse membership spanning five different Bacterial phyla as well as the Euryarchaeotal class Nanohaloarchaea. The patchy phylogenetic distribution of xenorhodopsin homologs is consistent with historical dissemination through horizontal gene transfer. Shared characteristics of xenorhodopsin-containing microbes include the absence of flagellar motility and isolation from high light habitats.
Reviewers: This article was reviewed by Dr. Michael Galperin and Dr. Rob Knight.
A new model for the characterization of infection risk in gunshot injuries:Technology, principal consideration and clinical implementation
Authors: von See Constantin , Rana Majeed , Stoetzer Marcus , Wilker Conrad , Rücker Martin , Gellrich Nils-Claudius 
Published: October 2011

Abstract

Introduction
The extent of wound contamination in gunshot injuries is still a topic of controversial debate. The purpose of the present study is to develop a model that illustrates the contamination of wounds with exogenous particles along the bullet path.

Material and methods
To simulate bacteria, radio-opaque barium titanate (3-6 μm in diameter) was atomized in a dust chamber. Full metal jacket or soft point bullets caliber .222 (n = 12, v0 = 1096 m/s) were fired through the chamber into a gelatin block directly behind it. After that, the gelatin block underwent multi-slice CT in order to analyze the permanent and temporary wound cavity.

Results
The permanent cavity caused by both types of projectiles showed deposits of barium titanate distributed over the entire bullet path. Full metal jacket bullets left only few traces of barium titanate in the temporary cavity. In contrast, the soft point bullets disintegrated completely, and barium titanate covered the entire wound cavity.

Discussion
Deep penetration of potential exogenous bacteria can be simulated easily and reproducibly with barium titanate particles shot into a gelatin block. Additionally, this procedure permits conclusions to be drawn about the distribution of possible contaminants and thus can yield essential findings in terms of necessary therapeutic procedures.
Cardiovascular and renal effects of carperitide and nesiritide in cardiovascular surgery patients: a systematic review and meta-analysis
Authors: Mitaka Chieko , Kudo Toshifumi , Haraguchi Go , Tomita Makoto 
Published: October 2011

Abstract
Introduction
Acute kidney injury (AKI) following cardiovascular surgery is a common disease process and is associated with both morbidity and mortality. The aim of our study was to evaluate the cardiovascular and renal effects of an atrial natriuretic peptide (ANP, carperitide) and a B-type (or brain) natriuretic peptide (BNP, nesiritide) for preventing and treating AKI in cardiovascular surgery patients.

Methods
Electronic databases, including PubMed, EMBASE and references from identified articles were used for a literature search.

Results
Data on the infusion of ANP or BNP in cardiovascular surgery patients was collected from fifteen randomized controlled trials and combined. The infusion of ANP or BNP increased the urine output and creatinine clearance or glomerular filtration rate, and reduced the use of diuretics and the serum creatinine levels. A meta-analysis showed that ANP infusion significantly decreased peak serum creatinine levels, incidence of arrhythmia and renal replacement therapy. The meta-analysis also showed that ANP or BNP infusion significantly decreased the length of ICU stay and hospital stay compared with controls. However, the combined data were insufficient to determine how ANP or BNP infusion during the perioperative period influences long-term outcome in cardiovascular surgery patients.

Conclusions
The infusion of ANP or BNP may preserve postoperative renal function in cardiovascular surgery patients. A large, multicenter, prospective, randomized controlled trial will have to be performed to assess the therapeutic potential of ANP or BNP in preventing and treating AKI in the cardiovascular surgical setting.
Serum thyroglobulin reference values according to NACB criteria in healthy subjects with normal thyroid ultrasound
Authors: Giovanella Luca , Imperiali Mauro , Ferrari Anna , Palumbo Alessia , Furlani Lino , Graziani Maria Stella , Castello Roberto 
Published: October 2011

AbstractThe present study was undertaken to establish serum thyroglobulin (Tg) normal reference values in a large group of healthy subjects.Four hundred and thirty-eight non-smoking healthy subjects were selected to assess the Tg reference values (209 males, 229 non-pregnant females, age 34.7±13.1 years). Inclusion criteria were: no personal or familial history of thyroid disease, thyrotropin levels from 0.5 to 2.00 mUI/L, negative thyroperoxidase and thyroglobulin antibodies. In addition, the patients had a normal size thyroid (females ≤18 mL, males ≤25 mL) without nodules on the thyroid ultrasound (TUS). According to National Academy of Clinical Biochemistry (NACB) criteria the Tg results were transformed to a logarithmic scale and reference ranges were calculated as mean±2 SD.Serum Tg was measured on the Beckman Coulter UniCel DxI 800 automated platform by the simultaneous 1-step immunoenzymatic Access Thyroglobulin assay (Beckmann-Coulter SA, Nyon, Switzerland). Serum Tg levels were higher in females than in males (p=0.0022). Accordingly, gender-specific reference values were calculated (i.e., males: 1.40–29.2 ng/mL; females: 1.50–38.5 ng/mL).To the best of the authors’ knowledge, the first reference interval study for Tg that integrates NACB criteria and TUS assessment for the selection of the reference population is provided here.
Integrating Global Regulatory Input Into theSalmonellaPathogenicity Island 1 Type III Secretion System
Authors: Golubeva Yekaterina A , Sadik Adam Y , Ellermeier Jeremy R , Slauch James M 
Published: October 2011

AbstractSalmonella enterica serovar Typhimurium uses the Salmonella pathogenicity island 1 (SPI1) type III secretion system to induce inflammatory diarrhea and bacterial uptake into intestinal epithelial cells. The expression of hilA, encoding the transcriptional activator of the SPI1 structural genes, is directly controlled by three AraC-like regulators, HilD, HilC, and RtsA, each of which can activate the hilD, hilC, rtsA, and hilA genes, forming a complex feed-forward regulatory loop. A large number of factors and environmental signals have been implicated in SPI1 regulation. We have developed a series of genetic tests that allows us to determine where these factors feed into the SPI1 regulatory circuit. Using this approach, we have grouped 21 of the known SPI1 regulators and environmental signals into distinct classes on the basis of observed regulatory patterns, anchored by those few systems where the mechanism of regulation is best understood. Many of these factors are shown to work post-transcriptionally at the level of HilD, while others act at the hilA promoter or affect all SPI1 promoters. Analysis of the published transcriptomic data reveals apparent coregulation of the SPI1 and flagellar genes in various conditions. However, we show that in most cases, the factors that affect both systems control SPI1 independently of the flagellar protein FliZ, despite its role as an important SPI1 regulator and coordinator of the two systems. These results provide a comprehensive model for SPI1 regulation that serves as a framework for future molecular analyses of this complex regulatory network.
Use of Tamoxifen Before and During Pregnancy
Authors: Braems Geert , Denys Hannelore , De Wever Olivier , Cocquyt Veronique , Van den Broecke Rudy 
Published: October 2011

Abstract
For premenopausal patients with receptor-positive early breast cancer, administration of tamoxifen for 5 years constitutes the main adjuvant endocrine therapy. During pregnancy, tamoxifen and its metabolites interact with rapidly growing and developing embryonic or fetal tissues.
Information about tamoxifen and pregnancy was gathered by searching PubMed. In addition, we had access to the records of the pharmaceutical company AstraZeneca. Because these observations are retrospective and other therapies and diagnostic measures are possible confounders, a causal relationship was not established between tamoxifen treatment and pregnancy outcome.
The records from AstraZeneca documented three live births with congenital anomalies and four live births without congenital anomalies related to tamoxifen treatment before pregnancy. Tamoxifen therapy during pregnancy resulted in 16 live births with congenital malformations and a total of 122 live births without malformations. The 122 live births without malformations included 85 patients from a prevention trial that did not record a single anomaly, whereas the AstraZeneca Safety Database alone reported 11 babies with congenital malformations of 44 live births. Additionally, there were: 12 spontaneous abortions, 17 terminations of pregnancy without known fetal defects, six terminations of pregnancy with fetal defects, one stillbirth without fetal defects, two stillbirths with fetal defects, and 57 unknown outcomes.
The relatively high frequency of severe congenital abnormalities indicates that reliable birth control during tamoxifen treatment is mandatory. After tamoxifen use, a washout period of 2 months is advisable based on the known half-life of tamoxifen. In case of an inadvertent pregnancy, risks and options should be discussed.
The Prevalence of Headache and Associated Psychosocial Factors in an Urban Biracial Sample of Older Adults
Authors: Cohen Carl I. , Henry Katherine A. 
Published: October 2011

Objective: There are limited epidemiological data about headache in urban elderly persons in the United States, especially those from minority backgrounds. This article examines the prevalence of headache and associated psychosocial factors in a biracial sample of older adults in New York City. Methods: Data from a population-based sample consisting of 214 Caucasians and 859 Blacks aged 55 and over (mean age: 68 years) were analyzed using an adaptation of George's Social Antecedent Model of Psychopathology. The model consisted of 15 independent variables, one interactive variable, and a dependent variable that dichotomized headaches that bothered respondents into “none or little of the time” versus “some, a good part, or most of the time” in the past few weeks. Results: Controlling for design effects, 17.8% of the sample met headache criteria. For the entire sample, logistic regression analysis indicated that headache was significantly associated with anxiety symptoms, depressive symptoms, religiosity, and a smaller proportion of confidantes. When examined separately, headache among blacks was significantly associated with anxiety symptoms, larger social networks, and greater financial strain. Among Caucasians, headache was associated with anxiety symptoms, smaller social networks, religiosity, physical illness, and higher daily functioning. Conclusions: The study confirms earlier findings that anxiety and depressive symptoms are associated with headache in older adults. The results also identify other psychosocial factors that may differ by race. These findings have important implications with respect to the etiology and management of headache in older adults.
L'interstitiel, un lieu fécond pour penser les liens entre-deux
Authors: Bourion Christian , Barth Isabelle 
Published: October 2011

Résumé Dans ce monde en émergence, on sait que la ressource essentielle ne sera plus la matière mais la pensée. Il en résulte que la qualité et l’opérationnalité d’une discipline scientifique sera inversement proportionnelle au volume de ses impensés. L’impensé est un espace vide de sens entre deux concepts. De nombreux phénomènes sociétaux font l’objet d’impensés, particulièrement au sein des organisations éducatives, commerciales ou religieuses. Toutefois, la méthodologie de repérage est spécifique : on ne peut collecter des données sur un « ensemble vide » avec les méthodes qui permettent de collecter des données sur des ensembles habités. Il est toutefois possible de procéder à ce type de recherche en s’inspirant de la sérendipité, de l’Evidence-Based Medicine (EBM), de la Grounded Theory (GT), en collectant des retours d’expérience (REX), en utilisant la puissance des moteurs de recherche et les logiciels adéquats, comme le montre l’exemple développé.
Quand on se suicide au travail
Authors: Brodier Philippe 
Published: October 2011

Résumé Se suicider au travail a émergé sur la scène médiatique ces dix dernières années. En corollaire, se sont engouffrés de nombreux leaders d’opinion de toute sorte qui selon leurs intérêts ou leurs idéologies ont livré leurs interprétations obligeant à une compréhension partisane de la situation. Pour se dégager de cette contrainte, cette réflexion vise à éclairer les interstices entre le suicide et le management, d’en expliciter les liens et les dépendances au travers de différents outils et concepts psychanalytiques. La conjonction de la métapsychologie de la dépression associée à la topique narcissique semble être opérante pour expliquer le passage à l’acte suicidaire. Ainsi, il apparaît que le suicide au travail n’est pas l’aboutissement d’un stress insupportable ou l’issue dramatique de contraintes instituées par un nouveau capitalisme. Au-delà des concepts analytiques usités, ceux-ci sont nourris par les événements dramatiques qui se sont déroulés au sein de Renault et de France Télécom avec en filigrane la tentative de répondre à la question : pourquoi là et non pas dans une autre entreprise ? A l’heure de la société libérée et individualiste de masse où chacun est laissé libre de donner le sens qu’il entend à sa vie, lorsque le sens s’échappe au travail, il est parfois difficile de ne pas s’échapper avec lui.