bluuebunny/crossref_metadata_2025_split huggingface dataset:
A New Method for Automatic Identification of Inter-Well Connectivity in Heterogeneous Reservoirs Based on Affinity Propagation Unsupervised Learning
Authors: Zhang Lingfeng , Liao Xinwei , Shen Chuanhai , Dong Peng , Ou Yuhao , Tao Ran , Wang Xiaochen 
Published: April 2024

Abstract
Identifying inter-well connectivity is essential for reservoir development adjustment and optimization, but the actual working and reservoir conditions are complex, making the task difficult to do manually. Therefore, a set of unsupervised machine learning algorithms based on affinity propagation (AP) is developed in this work to cluster and map production data of oil wells in two dimensions and then extract inter-well topology to achieve automatic identification of inter-well connectivity. To better respond to the conditional independence of the variables, the Graphical Lasso algorithm is used to find the inter-well correlation matrix. Finally, the Local Linear Embedding (LLE) algorithm is used to embed the production data of the wells into a two-dimensional plane to visualize the clustering results and inter-well connectivity relationships.
Results show that production wells close to the fault can be aggregated automatically, which proves that the method can identify the impermeable boundaries. In addition, the process can automatically cluster production wells of different permeability zones and distinguish production wells at the junction of low and high permeability zones. Finally, this method is applied to the production data of 63 wells in an actual reservoir. The model divides the oil well into four macro-level regions, which is consistent with geological understanding. At the microscopic level, five groups of wells with highly similar production variations were automatically detected, and the presence of high permeability channels between them was accurately identified. The proposed method has important practical significance for reservoir development adjustment and geological understanding.
Delivery of Curcumin Using Colloidal Complexes Formed from Ammonium Chitosan and Acid Treated Soybean Protein
Authors: Weng Shuni , Su Huanhuan , McClements David Julian , Wang Yuting , Li Teng , Fu Yuying 
Published: April 2024

Abstract

Curcumin (CUR) is found to exhibit a broad spectrum of potentially beneficial biological activities, which make it suitable as a nutraceutical ingredient in functional foods and supplements. But its application for this purpose is often limited by its low water-solubility, chemical stability, and bioavailability. In this study, acid-treated soybean protein isolate (SPI) and chitosan quaternary ammonium salt (CQAS) were used to assemble colloidal carriers for CUR to form soybean protein isolate-curcumin-chitosan quaternary ammonium salt nanoparticles (SPI-CUR-CQAS NPs). The nanoparticles formed were relatively small (< 200 nm), approximately spherical, and strongly positively charged (> 43 mV). Fluorescence spectroscopy demonstrated that the dominant interaction between CUR and SPI was hydrophobic attraction, while the dominant interaction between CQAS and SPI was electrostatic attraction. The encapsulation efficiency (95.4%) and loading capacity (14%) of the SPI-CUR-CQAS NPs (pH 1.5) were relatively high. The vitro digestion experiments showed that the CUR was progressively released from the nanoparticles under stomach, small intestine, and colon conditions. Moreover, the final bioavailability of the encapsulated CUR (65%) was much higher than for free CUR (16%). The SPI-CQAS NPs developed in this study can therefore be used as an effective delivery system for CUR in functional foods.
Mechanochemically Responsive Polymer Enables Shockwave Visualization
Authors: Chan Edwin , Centellas Polette , Mehringer Kyle , Bowman Andrew , Evans Katherine , Vagholkar Parth , Thornell Travis , Huang Liping , Morgan Sarah , Soles Christopher , Simon Yoan 
Published: April 2024

Abstract

Understanding the physical and chemical response of materials to impulsive deformation is crucial for applications ranging from soft robotic locomotion 1–3 to space exploration 4,5 to seismology 6. However, investigating material properties at extreme strain rates remains challenging due to temporal and spatial resolution limitations. Combining high-strain-rate testing with mechanochemistry uniquely encodes the molecular-level deformation within the material itself, thus enabling the direct quantification of the material response. Here, we demonstrate a mechanophore-functionalized block copolymer that self-reports unique energy dissipation mechanisms, such as bond rupture and acoustic wave dissipation, in response to high-strain-rate impacts. A microprojectile accelerated towards the polymer permanently deforms the material at a shallow depth. At intersonic velocities, the polymer reports significant subsurface energy absorption due to shockwave attenuation, a mechanism traditionally considered negligible compared to plasticity and not well explored in polymers. The acoustic wave velocity of the material is directly recovered from the mechanochemically-activated subsurface volume recorded in the material, which is validated by simulations, theory, and acoustic measurements. This integration of mechanochemistry with microballistic testing enables characterization of high-strain-rate mechanical properties and elucidates new insights applicable to nanomaterials 7, particle-reinforced composites 8, and biocompatible polymers 9.
Chinese experience in hematopoietic stem cell mobilization and collection in lymphoma patients: a retrospective cohort study
Authors: Lv Jie , Mi Lan , Liu Weiping , Wang Xiaopei , Song Yuqin , Zhu Jun , Zhang Chen 
Published: April 2024

Abstract

Lymphoma can be treated with autologous hematopoietic stem cell transplantation. The mobilization and collection of hematopoietic stem cells is essential for the success of stem cell transplantation. From January 2017 to December 2022, 561 patients who had undergone autologous hematopoietic stem cell mobilization and collection at Peking University Cancer Hospital were analyzed retrospectively. In the post-plerixafor era, the parameters of the mobilization and collection of stem cells have changed. Some factors still influence the number of stem cells collected, such as age, pre-apheresis blood platelet counts, peripheral blood CD34 + cells; However, the pathological type of patients, bone marrow infiltration, number of treatment lines, and whether small molecule drugs such as lenalidomide were used had no significant effect on the number of CD34 + cells collected. Although the number of CD34 + cell yields in chemo-mobilization is indeed higher than that in steady-state mobilization, clinicians also need balance benefits versus risks to select appropriate mobilization regimens. Plerixafor as a new mobilizer can improve the results of CD34 + cell yields, with cost-effectiveness being taken into account.
Prevalence of functional difficulty among school-aged children and effect on school enrolment in rural southern India: A cross-sectional analysis
Authors: Chandy Bobeena Rachel , Davey Calum , Oswald William E , Kaliappan Saravanakumar Puthupalayam , Aruldas Kumudha , Banks Lena Morgon , Jasper Smitha , Nagarajan Guru , Galagan Sean , Kennedy David S , Walson Judd L , Koshy Beena , Ajjam Sitara SR , Kuper Hannah 
Published: April 2024

Abstract
Despite the large number of children in India, there is little information on the impact of children’s disability on school enrolment, and how this differs by population. We estimated the prevalence of childhood disability in two sites in Tamil Nadu, southern India, and the effect of functional difficulty on school enrolment. We used a parent-reported survey containing the UNICEF-Washington Group questions to identify children aged 5 to 17 years with functional difficulty during a census conducted for an ongoing trial. We estimated pooled- and gender-specific prevalence of functional difficulty among 29,044 children. We fitted regression models to identify subgroups with higher rates of functional difficulty and the effect of functional difficulty on reported school enrolment. We estimated the modification of the effect of functional difficulty by age, gender, socioeconomic status, household education, and sub-site, on additive and multiplicative scales. We found of 29,044 children, 299 (1.0%) had any functional difficulty, equal among boys and girls. Being understood (0.5%) and walking (0.4%) were the most common difficulties. Functional difficulty was strongly associated with non-enrolment in school (Prevalence ratio [PR] 4.59, 95% CI: 3.87, 5.43) after adjusting for age, gender, and site. We show scale-dependent differences between age and socioeconomic groups in the effect of functional difficulty on enrolment. This study shows that at least one in a hundred children in this region have severe functional difficulties and nearly half of these children are not enrolled in school, highlighting the need for further efforts and evidence-based interventions to increase school enrolment among these groups.
High-grade cervical intraepithelial neoplasia co-existing with vaginal intraepithelial neoplasia increased the risk of persistent human papillomavirus infection and residual/recurrent disease after LEEP
Authors: Zhang Jing , Zhu Yanmei , Yang Di , Liu Guangcong , Wang Danbo 
Published: April 2024

Abstract

Purpose
Cervical intraepithelial neoplasia (CIN) with co-existent vaginal intraepithelial neoplasia (VaIN) is a challenge in clinical management. This study was aimed to evaluate the association of having co-existent CIN and VaIN with persistent high-risk HPV (HR-HPV) infection and with residual/recurrent disease after treatment.
Methods
A retrospective study was performed involving women treated for co-existent CIN2/3 and VaIN and those treated for CIN2/3 only between January 2018 and December 2020. CIN2/3 was treated with LEEP, and VaIN was treated with electrocoagulation (fulguration) at the time of CIN treatment. First follow-up was conducted by HPV-based testing at 3–6 months after treatment. Persistent HPV infection and residual/recurrent disease after treatment are the outcomes of the study. Univariate and multivariate analyses were used to assess the risk factors of persistent HR-HPV infection and residual/recurrent disease.
Results
Among 676 women with CIN 2/3, 83 (12.3%) women had co-existent VaIN. Age ≥ 50 years (odds ratio, OR = 3.105, 95% confidence interval, CI = 1.399–6.889) and multiple HPV infections (OR = 2.692, 95% CI = 1.406–5.155) were associated with an increased risk of co-existent CIN and VaIN. At the 1st follow-up, 195 (28.8%) of 676 women had persistent HR-HPV infection, which was more common in women having co-existent CIN and VaIN compared those with CIN only (49.4% vs. 26.0%, P < 0.001). After adjusting for potential confounding factors, co-existent CIN and VaIN was an independent risk factor for persistent HR-HPV infection (OR = 2.844, 95% CI = 1.446–5.595) and for residual/recurrent disease (OR = 4.876, 95% CI = 1.131–21.028) after treatment.
Conclusions
Co-existent CIN and VaIN increased the risk of persistent HR-HPV infection and residual/recurrent disease after treatment. Close follow up was proper for women having co-existent CIN and VaIN.
Reduced Systemic Microvascular Function in Patients With Resistant Hypertension and Microalbuminuria: an Observational Study
Authors: TIBIRICA Eduardo , Verri Valeria , Lorenzo Andrea , Crahim Vinicius 
Published: April 2024

Abstract

Resistant hypertension (RH) may be associated with microalbuminuria (MAU), a marker of increased mortality, and both may be related to microvascular damage. Laser speckle contrast imaging (LSCI) is an innovative approach for noninvasively evaluating systemic microvascular endothelial function useful in the context of RH with or without MAU. Microalbuminuria was defined as a urine albumin-to-creatinine ratio between 30 and 300 mg/g. Microvascular reactivity was evaluated using LSCI to perform noninvasive measurements of cutaneous microvascular perfusion changes. Pharmacological (acetylcholine [ACh], or sodium nitroprusside [SNP]) and physiological (postocclusive reactive hyperemia [PORH]) stimuli were used to evaluate vasodilatory responses. Thirty-two patients with RH and a normal urine albumin-to-creatinine ratio (RH group) and 32 patients with RH and microalbuminuria (RH + MAU) were evaluated. Compared with patients without MAU, patients with RH + MAU showed reduced endothelial-dependent systemic microvascular reactivity, as demonstrated by an attenuation of microvascular vasodilation induced by PORH. On the other hand, ACh-induced vasodilation did not differ between groups. The results also revealed reduced endothelial-independent (SNP-induced) microvascular reactivity in hypertensive patients with MAU compared with patients without MAU. In this study, there was evidence of endothelial dysfunction associated with impaired microvascular smooth muscle function in patients with RH + MAU. This may suggest that patients with RH need more intensive therapeutic strategies for the control of blood pressure to avoid further vascular damage and the resulting consequences.
BAP1 serves as a clear-cell renal cell carcinoma suppressor and is inversely regulated by miR-200c-3p
Authors: Wei Du , Wenyu Ge , Ling Yu , Hongzhe Chen , Dongmei Wang , Xinglu Xu 
Published: April 2024

Abstract

The initiation and development of malignant tumor is always accompanied by a series of complex gene expression alterations inside the cells. As a tumor suppressor, the deubiquitinating enzyme BAP1 has been identified as an important regulator on the outcomes and biological properties of clear-cell renal cell carcinoma (ccRCC). However, BAP1-involved intracellular regulatory cascades in clear-cell renal cell carcinoma are still not fully understood. In this study, we provided evidence that the protein levels of BAP1 were dramatically diminished in clear-cell renal cell carcinoma in vitro and in vivo. Notably, the relatively low expression of BAP1 is significantly associated with worse prognosis in ccRCC patients. Besides, through the prediction of bioinformatics methods and verification of biological experiments, we confirmed that miR-200c-3p was the direct upstream regulator of BAP1. Taken together, our study presents an important role of miR-200c-3p/BAP1 in the development of ccRCC, which provided an alternative strategy for treating ccRCC in clinical practice.
Numerical study of the free convection of a hybrid nano-fluid filling a three-dimensional cavity exposed to a horizontal magnetic field
Authors: Benshab Mouna , Bouchta Said , FEDDAOUI M'Barek , Dayf Abdellatif , BOUCHTA Jaouad , Abderrahman Nait Alla 
Published: April 2024

Abstract

This work presents a numerical study of the effect of a horizontal magnetic field on free convection inside a three-dimensional enclosure filled with a hybrid nanofluid. The transport equations are discretized by the finite volume method. The SIMPLEC algorithm was used to couple the velocity and pressure fields. The vertical walls are heated differently and the horizontal walls are assumed to be adiabatic. The effects of Rayleigh number, volumetric fraction of particles and Hartmann number are studied. The results are given in the form of isotherms, streamlines and Nusselt numbers. It has been shown that for low Hartmann numbers the heat transfer intensifies with an increasing percentage of particles and a higher Rayleigh number. In addition, for low Hartmann numbers, it has been shown that the heat transfer intensifies with an increasing percentage of particles and a higher Rayleigh number. In return, for high Hartmann numbers, heat transfer decreases under the influence of the magnetic field.
Refinement Based Stochastic Model for Developing Water Supply System in Bangladesh
Authors: Asaduzzaman Md. , Hasan Mohammad Babul 
Published: April 2024

Abstract

In our everyday lives, we collect water, use it and emit used water into the canal. We use water for drinking, sanitary, and washing purposes in our everyday lives. The amount of water we use for washing purposes is huge. In this paper we will propose a model in which we consider the refining process of water, which will produced for washing purposes. Unrefined water is harmful for the ecosystem of the river. If we emit our used water, which we used for washing purposes under refining, then this used water is not harmful for the environment. We also reused the refined water for our secondary purposes, such as vehicle washing, any construction purpose, in the dying industry, etc. We solve the model under the assumption that the availability of water at the supplying authority is uncertain. We find the cost without refinement, and then we calculate the cost with the refining process by using our proposed model. We compare these two results. Finally, we calculate the expected value of perfect information (EVPI) and the value of stochastic solution (VSS) by calculating the wait-and-see solution (WS), the recourse solution (RS), and the expected solution by using the expected first-stage decision (EEV).
Maternal and Neonatal Outcomes of Post-Bariatric Surgery: A Population-Based Study
Authors: Al-Dewik Nader I. , Samara Muthanna , Mahmah Adel , Al-Dewik Aseel , Nahia Seba Abou , Abukhadijah Hana , Samara Yahya , Hammuda Sara , Razzaq Aleem , Al-Dweik Manar , Alahersh Asma , Moamed Lina , Singh Rajvir , Al-Obaidly Sawsan , Olukade Tawa , Ismail Mohamed , Alnaama Alaa , Thomas Binny , Silang John Paul Ben , Nasrallah Gheyath , Rizk Nasser , Qoronfleh M Walid , AlAlami Usama , Farrell Thomas , Abdulrof Palli Valapila , AlQubaisi Mai , Rifai Hilal Al 
Published: April 2024

Abstract

Objectives: This study has two main goals. The first step is to assess the incidence, risk factors, and maternal and neonatal outcomes in pregnant women who have undergone Bariatric Surgery (BS). Second, to analyze these effects among pregnant women without a history of BS, these include women who are obese, overweight, and of normal weight (non-exposed groups).
Methods: This population-based study was conducted using 12-month retrospective registry data from the PEARL-Peristat Study at the Women's Wellness and Research Center (WWRC) in Qatar.
A total of 6,212 parturient women and their respective offspring were examined. Participants were categorized into two groups: those with a history of Bariatric Surgery (post-BS) as the exposed group (N=315), and those without such a history as the non-exposed group (N=5,897). Both univariate and multivariable regression analyses were employed to scrutinize risk factors and outcomes.
Results: Qatari, advanced maternal age, parity >1, diabetes, and hypertension were found to be significant risk factors for women with post-BS. Also, women in the post-BS group were found to be more likely to have a cesarean delivery (37.5% vs. 24%, aOR=1.59, CI 1.18-2.14), preterm babies (10% vs. 7%, aOR=1.66, CI 1.06-2.59), and stillbirth (1.6% vs. 0.4%, aOR=4.53, CI 1.33-15.50) compared to the normal weight women group. Moreover, post-BS women had a higher risk of low-birth-weight neonates than obese (15% vs. 8%, aOR= 1.77, CI 1.153-2.73), overweight (15% vs. 7%, aOR=1.63, CI:1.09-2.43), and normal weight (15% vs. 8%, aOR=1.838, CI 1.23-2.75) women. Finally, women in the post-BS group were more likely to have low-birth-weight neonates amongst term babies than obese and overweight women.
Conclusion: Pregnancies with post-BS should be considered a high-risk group for certain medical outcomes and should be monitored closely. These findings may guide the future clinical decisions of antenatal and postnatal follow-up for post-BS women.
Spatial-Temporal Monitoring of Groundwater Quality at the Northeast Coast of Alexandria, Egypt Short Title: Spatial-Temporal Monitoring of Groundwater Quality
Authors: Bestawy Ebtesam El , Tonbol Kareem , Omar Mohamed Youssef , Ahmed Ragaa Ahmed Mahmoud 
Published: April 2024

Abstract

The degradation of water quality poses a significant challenge to the utilization of freshwater resources for human activities, which threatening agricultural productivity and the functioning of aquatic ecosystems. The quality of irrigation water is greatly affecting both crop health and production. Hence, there is a must to enhance understanding of the quality of irrigation water. The aim of this assessment is to determine the suitability and compatibility of water sourced from 13 borehole ground wells located at the northeast coast of Alexandria, Egypt, Abu Qir district, with emphasis on the ability of usage for irrigation purposes. The research areas comprise the combination of urban, including residential complexes and academic campuses, alongside agricultural activity. A total of 52 groundwater samples were collected throughout the four seasons of winter, spring, summer, and autumn in the year 2022, with the objective of determining how they fit for agricultural use. Results revealed that the tested groundwater from the selected wells lied in the moderate to poor water quality for irrigation based on SAR, SSP, RSC, KR, PI, CAI, PS, MH, TDS, and TH indices. Therefore, using such groundwater for irrigation in the specified research area poses real dangers for crop health and agricultural productivity unless receive appropriate treatment.
A storyline of ozone pollution extremes in warmer climates
Authors: Emmerichs Tamara , Shen Fuzhen , Gromov Sergey , Hegglin Michaela , Wahner Andreas , Taraborrelli Domenico 
Published: April 2024

Abstract
High ozone levels pose a significant threat to human health and ecosystems, especially during extreme weather events. These are expected to become more frequent and intense with climate change, exacerbating the interactions between weather, vegetation, and air pollution. Traditionally a climate change penalty is expected for ground-level ozone is expected. However, models do not even agree on the sign of the change over most of the continents suggesting an important role for vegetation. We address this uncertainty by incorporating realistic vegetation responses to abiotic stress into a global atmospheric chemistry model. We develop novel storyline scenarios of air pollution, contrasting the actual climate of 2018-2020 with two different levels of warming. Our results show that under warming, vegetation and local photochemistry generally conspire to exacerbate ozone pollution extremes, while a concurrent moistening of the free troposphere leads to a lower ozone background. The competition between these two effects depends on the degree of warming and will determine whether climate change results in a penalty or a benefit. However, the role of changing pollutant emissions remains uncertain and should be addressed in future studies.