bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selection of cervicalgia›s analgesia management in the prehospital stage in everyday ambulance operations and possible emergency situations
Authors: Tarakanov A. V. , Tarakanov A. A. , Los E. G. , Yakushev I. D. , Khatisova E. V. , Lisina O. A. , Skorodumova E. G. 
Published: February 2025

Purpose of the study: to evaluate the analgesic efficacy of ketoprofen, ketorolac, sodium metamizole (combination with pithophenone and fenpiverinium bromide) and percutaneous neurostimulation method for the choice of optimal analgesia of nonspecific cervicalgia in the conditions of daily ambulance work and possible emergency situations.Materials and methods of the study: in 160 patients in conditions of real work of emergency medical aid in 7 cities of the Russian Federation were used: 1 gr. — Ketoprofen («Ketonal») (100 mg), intramuscularly (n=31); 2 gr. — ketorolac tromethamine («Ketorol») (30 mg), intramuscularly (n=25); 3 gr. — Metamizole sodium 500 mg, pitofenone 2 mg, fenpiverinium bromide 20 mcg («Baralgin») in 1 ml, 5 ml intramuscularly (n=22); 4 gr. — percutaneous neurostimulation (CHENS-SCENAR-02) (n=82).Results of the study: cervicalgia was accompanied by complaints of headache (86%), «noise» in the head (33%), dizziness (25%), less frequently by complaints of paresthesias in the hands, cardialgia, nausea, agitation or lethargy in antalgic posture. Reliable analgesic efficacy with evaluation on visual analogue scale is realized by 10 minutes by 20–25% decrease of pain; by 40 minutes by 70%; reduction of cranialgia to 20–40% of the initial one is noted. A slight decrease in BP, HR and HR was registered; ketorolac and SCENAR-therapy were the most effective in these parameters. There were no significant side effects in any group.Conclusion. Ketoprofen and ketorolac are the most effective in the conditions of daily activities of the emergency department and possible emergencies, and percutaneous neurostimulation is also possible in conditions of drug deprivation and/or contraindications to pharmacotherapy.
Ankyrin repeat domain 1 is dysregulated in keloids and suppresses keloid fibroblast growth, migration, and extracellular matrix deposition
Authors: Wu Weiqi , Si Yuan , Yang Juan , Wen Liuyan , Li Jingrong 
Published: February 2025

Objective
The etiology and specific pathological mechanisms of keloids remain elusive. Array expression profiling has revealed dysregulation of the transcription cofactor ankyrin repeat domain 1 (ANKRD1) in keloid fibroblasts. The present study focused on examining the expression pattern of ANKRD1 in keloids and assessing its function in human keloid fibroblasts (HKFs).

Material and Methods
Differential mRNA expression profiles in keloid fibroblasts were investigated by analyzing data from gene expression omnibus (GEO) datasets. Immunohistochemistry assays were performed to verify the expression patterns of ANKRD1 and claudin 11 (CLDN11) in keloid tissue samples. Functional studies were conducted by transfecting HKFs with either a small interfering RNA (siRNA) targeting ANKRD1 (siANKRD1) or ANKRD1-overexpressing plasmids. The functional impact of ANKRD1 was assessed using cell proliferation, flow cytometry, and Transwell migration assays. mRNA expression was evaluated using reverse transcription polymerase chain reaction, and protein expression was determined using Western blotting.

Results
Analysis of the GEO series (GSE) GSE44270 revealed eight differentially expressed mRNAs, with ANKRD1 and CLDN11 being the top two downregulated mRNAs. ANKRD1 expression was observed to be lower in keloid tissues than in normal skin tissues, whereas CLDN11 expression showed no significant difference between the two groups. ANKRD1 overexpression suppressed HKF proliferation, migration, and the expression levels of collagen I, fibronectin, matrix metallopeptidase 9, whereas the opposite effects were observed on ANKRD1 knockdown. ANKRD1 did not affect apoptotic cell levels.

Conclusion
ANKRD1 is downregulated in keloids and inhibits the growth, migration, and extracellular matrix deposition of keloid fibroblasts. Thus, ANKRD1 may function as a suppressor in keloid formation.
ФИТОХИМИЧЕСКИЙ СОСТАВ ВИДОВ РОДА ARTEMISIA L. ЮЖНОГО КАЗАХСТАНСКОГО РЕГИОНА
Authors: Рахимбердиева Ж.Ш. , Арыстанова С.Д. , Жуматаева У.Т. 
Published: February 2025

В настоящей статье проведены результаты исследования по химическому изучению видов рода Астровые (Asteraceae), травянистое растение из рода Полынь (Artemisia L.) собранной на территории из районов (Арыс (село Дармине), Байдибекской (село Шаян), Шардаринской (село Алатау батыр)) Южного Казахстана. Род Полынь (Artemisia L.) является мало изученным в научной сфере. Цель работы выделить и определить из (Artemisia karatavica Krasch. & Abolin ex Poljakov, Artemisia cina Berg ex Poljakov, Artemisia porrecta Krasch. ex Poljakov) надземной части полыни химический состав. Инулин определяли по методу Бертрана. Витамина «С» определили титриметрическим методом. Углеводы определили перманганатным методом В результате проведенных исследований получены результаты витамина «С», углеводы, каротины, инулин и полифенолы. Большая часть этих веществ из трех (Artemisia karatavica Krasch. & Abolin ex Poljakov, Artemisia cina Berg ex Poljakov, Artemisia porrecta Krasch. ex Poljakov) образцов витамина «С», углеводы, каротины, инулин и полифенолы обнаружилась у полыни Каратауской что позволяет рекомендовать исследованные виды полыней для последующего изучения в качестве потенциальных источников растительного сырья.
ТАБИҒИ РЕСУРСТАРДАН КӨМІРТЕКТІ МАТЕРИАЛДАРДЫ АЛУ: ШОЛУ
Authors: Шинибекова Асем , Диаз де Туеста Хосе Луиз , Масалимова Бакытгуль 
Published: February 2025

Қазіргі таңда судан ауыр металдарды жою үшін химиялық тұндыру, электрохимиялық әдіс, ион алмасу, мембраналық сүзу және адсорбция қолданылады және бұл технологиялар нақты жағдайларда артықшылықтары мен кемшіліктері бар. Жою сыйымдылығын, энергияны тұтынуды, пайдалану жағдайларының сезімталдығын және екіншілік ластануды ескерсек, адсорбция әдісі ең жақсы процесс болып табылады. Кәдімгі адсорбенттерге арзан материалдар, көміртегі бар материалдар және түрлендірілген материалдар жатады және бұл адсорбенттердің әртүрлілігі мен шығу көздері ауқымды болып табылады, оларды суды тазартуда әртүрлі елдер мен аймақтардағы жергілікті жағдайларға сәйкес таңдауға болады. Адсорбцияның негізгі сипаттамаларының маңыздысы: пайдаланудың қарапайымдылығы, жаңартылатын адсорбент және төмен уыттылық болып табылады, бұл судағы ауыр металдарды жою кезінде адсорбцияны қолданудың тиімділігін көрсетеді.
Жыл өткен сайын жиналған дәнді дақылдар көп мөлшерде ауыл шаруашылығы қалдықтарын шығарады. Белсендірілген көмір сияқты сұранысқа ие адсорбентті өндіру үшін бастапқы материал ретінде ауылшаруашылық қосалқы өнімдерін пайдалану жиналған дақылдың құндылығын арттырады. Дамушы елдердің көпшілігінде белсендірілген көмір импортының жоғары құны олардың өз халқы үшін жеткілікті қауіпсіз ауыз су өндіру мүмкіндігінің шектеулілігін түсіндіреді. Бүкіл әлемде ауыз суды тазарту үшін арзан және қолайлы технологияларды қолдануға баса назар аударылып отыр. Алдыңғы зерттеулер суды тазарту үшін жергілікті материалдарды өндіру үшін жергілікті ауылшаруашылық қалдықтарын пайдалануға бағытталған. Құрамында көміртегі мөлшері жоғары, бейорганикалық заттардың мөлшері аз, ұшқыш заттардың мөлшері жоғары, тығыздығы жоғары, сақтау кезінде ыдырауы аз, активтенуге бейім, өз ішінде микроқұрылымдары бар және белсендірілген кезде жоғары өнімділік беретін үлкен материалдар ретінде белсендірілген көмірді алу үшін ең қолайлы параметрлар болып табылады.
Developing Collaborative Governance Capabilities for Sustainable Development at Santer Application in Samarinda City
Authors: Perwitasari Dyah Rahayuning , Dyah Kuntorini Dwi Angreni  , Lara Ayu Lestari  , Bulan Erika Bato  , Iqbal Saputra Zana  
Published: February 2025

Governments, development organizations, and others must increase their ability to tackle the complex difficulties of sustainable development. Significant investments in governance networks are being made by non-governmental groups. Nevertheless, excitement for there isn't always empirical support for the establishment of governance networks. This disparity presents difficulties. These groups to determine the value of their time and effort spent investing in governance networks; an assessment that is very important when resources are few. We assess the using a qualitative case study conducted in Samarinda City. proportionate share that the Santer Program, a governance network, made to four Individual, relational, organizational, and institutional are dimensions of collaborative governance capacity. We discover that the network contributed only moderately to the capacity of the individual, the relationship, and the organization, but the institutional capacity held steady in spite of the network's existence. This research is a qualitative study that will be conducted by reviewing the literature and examining the existing facts and data. Based on these findings, we argue that governance networks are not a panacea. Continued efforts are needed to establish when, how, and in what contexts collaborative networks are effective for building collaborative capacity for sustainable development. It would be fruitful for future studies to investigate how collaborative capacity changed over time, and in particular if increases in collaborative governance ability persisted after the network had stopped.
Keywords: Collaborative Governance, Collaborative capacity, Samarinda City, Samarinda Santer
A novel classification method for LUAD that guides personalized immunotherapy on the basis of the cross-talk of coagulation- and macrophage-related genes
Authors: Li Zhuoqi , Chen Ling , Wei Zhigang , Liu Hongtao , Zhang Lu , Huang Fujing , Wen Xiao , Tian Yuan 
Published: February 2025

PurposeThe coagulation process and infiltration of macrophages affect the progression and prognosis of lung adenocarcinoma (LUAD) patients. This study was designed to explore novel classification methods that better guide the precise treatment of LUAD patients on the basis of coagulation and macrophages.MethodsWeighted gene coexpression network analysis (WGCNA) was applied to identify M2 macrophage-related genes, and TAM marker genes were acquired through the analysis of scRNA-seq data. The MSigDB and KEGG databases were used to obtain coagulation-associated genes. The intersecting genes were defined as coagulation and macrophage-related (COMAR) genes. Unsupervised clustering analysis was used to evaluate distinct COMAR patterns for LUAD patients on the basis of the COMAR genes. The R package “limma” was used to identify differentially expressed genes (DEGs) between COMAR patterns. A prognostic risk score model, which was validated through external data cohorts and clinical samples, was constructed on the basis of the COMAR DEGs.ResultsIn total, 33 COMAR genes were obtained, and three COMAR LUAD subtypes were identified on the basis of the 33 COMAR genes. There were 341 DEGs identified between the three COMAR subtypes, and 60 prognostic genes were selected for constructing the COMAR risk score model. Finally, 15 prognosis-associated genes (CORO1A, EPHA4, FOXM1, HLF, IFIH1, KYNU, LY6D, MUC16, PPARG, S100A8, SPINK1, SPINK5, SPP1, VSIG4, and XIST) were included in the model, which was efficient and robust in predicting LUAD patient prognosis and clinical outcomes in patients receiving anti-PD-1/PD-L1 immunotherapy.ConclusionsLUAD can be classified into three subtypes according to COMAR genes, which may provide guidance for precise treatment.
Sheep-Derived Lactobacillus johnsonii M5 Enhances Immunity and Antioxidant Capacity, Alleviates Diarrhea, and Improves Intestinal Health in Early-Weaned Lambs
Authors: Wang Zhuo , Zhao Yuwei , Fan Dingkun , Zhang Jixian , Diao Qiyu , Cui Kai 
Published: February 2025

The early weaning of lambs frequently leads to weakened immunity, impaired intestinal function, and increased susceptibility to intestinal disease. Lactobacillus plays a role in regulating immunity, enhancing antioxidant capacity, and maintaining intestinal health. This study aims to isolate a strain of Lactobacillus with favorable probiotic properties from sheep feces and investigate its effects on the intestinal health of early-weaned lambs. In this study, the growth characteristics, acid production capacity, bacteriostatic capacity, bile salt tolerance, gastrointestinal fluid tolerance, self-coagulation capacity, and surface hydrophobicity of Lactobacillus isolated from sheep feces were analyzed for in vitro probiotic properties. Lactobacilli with strong probiotic properties were used for in vivo validation. A total of 72 Hu lambs were allocated into four groups: a ewe-reared group (ER), early-weaning group (EW), low-dose Lactobacillus group (LL), and high-dose Lactobacillus group (HL). Early weaning was performed in the EW, LL, and HL groups at the age of 28 days. Lactobacillus johnsonii M5 (L. johnsonii M5), isolated from sheep feces, exhibited strong probiotic properties in vitro. Feeding EW lambs with a low dose of L. johnsonii M5 significantly reduced their diarrhea rate (p < 0.05). Its supplementation increased the levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and total antioxidant capacity (T-AOC) in serum and jejunal mucosa and decreased levels of malondialdehyde (MDA) (p < 0.05). Compared to the EW group, serum immunoglobulin G (IgG) levels were significantly increased in the LL group (p < 0.05). Compared to the EW group, feeding with L. johnsonii M5 increased the content of anti-inflammatory cytokines, while reducing the content of pro-inflammatory cytokines in serum and jejunal mucosa (p < 0.05). Feeding early-weaned lambs with L. johnsonii M5 also decreased jejunal crypt depth and increased occludin and claudin-1 in jejunal mucosa (p < 0.05). These findings indicate that feeding early-weaned lambs with L. johnsonii M5 enhances their immunity and antioxidant capacity, improving intestinal health, and mitigates diarrhea in early-weaned lambs.
A recepção da Antiguidade Clássica na Contemporaneidade
Authors: Frandji Ingrid Cristini Kroich 
Published: February 2025

Nas últimas décadas, os estudos sobre a Antiguidade Clássica passaram a abranger também o impacto das civilizações antigas na formação de identidades nacionais, suas utilizações e retomadas a partir de aspectos políticos e artísticos, ligados aos produtos culturais próprios dos séculos XX e XXI. Compreendendo a relevância do mundo antigo e suas diferentes apropriações e releituras nos últimos três séculos, o presente artigo discorre sobre os resultados obtidos no âmbito do projeto A Recepção da Antiguidade Clássica na Contemporaneidade (2000-2020), desenvolvido na UNESPAR – Campus Paranaguá entre 2022 e 2023. São apresentados os dados quantitativos de cinco eixos de pesquisa (filmes, álbuns musicais, histórias em quadrinhos, séries e jogos). A partir destes dados, algumas considerações parciais são apresentadas, em especial sobre a relação entre os estudos da recepção e ensino de História.
3D Printing Errors Detection During the Process
Authors: MARIN Florin-Bogdan , MARIN Mihaela 
Published: February 2025

Automated error detection in 3D printing is an important challenge that impacts not only the quality of the final parts but also operational efficiency, helping to minimize wasted time and material. Certain types of errors can even result in printer malfunctions. A widely used solution for monitoring the printing process involves employing a webcam to observe the process in real time, either alerting the operator or halting the print if an issue is detected. In this paper, a computer vision algorithm able to detect specific errors is proposed.
Concrete for tidal power plant (on the 50th anniversary of the Kislogubskaya tidal power plant in the Arctic)
Authors: Usachev I. N. , Rozental N. K. , Chekhnii G. V. 
Published: February 2025

Introduction. The first experimental tidal power station in Russia has been operating in the Kislyaya Bay of the Barents Sea, Arctic Region, since December 1968. Constructed using float-on methods, it is recognized as an outstanding structure of the 20th century and has been designated as a “Monument of Science and Technology of the Russian Federation.” The paper discusses the research on frost resistance and corrosion resistance of monolithic concrete and reinforced concrete used in the tidal power plant.Aim. To summarize half a century of research and observations on reinforced concrete structures of this large facility and experimental samples of concrete and reinforced concrete in the harsh marine conditions of the Arctic.Materials and methods. High-strength, frost-resistant, and low-permeability concrete was utilized. The methodology involved laboratory and long-term field tests, including systematic inspections of the condition of concrete samples and reinforced concrete structures of the tidal power plant, with assessments of their strength and frost resistance.Results. The study demonstrated high frost resistance and corrosion resistance in the marine environment under prolonged exposure to low temperatures typical of the Arctic zone, ensuring the complete preservation of structures over 50 years of operation in harsh Arctic sea conditions, including tidal zones and ice impact.Conclusions. The findings confirm the feasibility of constructing and maintaining reinforced concrete structures for tidal power plantss in marine Arctic conditions without repair for an extended period (up to fifty years).
A Systematic Literature Review on the Relationship Between Smart Learning Environments and Learning Performance in Higher Education
Authors: Gao Jing , Ismail Normala 
Published: February 2025

Smart learning environments, as an advanced educational technology, are widely acknowledged as a crucial component of contemporary educational systems. This study aims to examine the current literature concerning smart learning environments and their influence on learning performance in higher education. The writers examine papers published in ERIC over the past decade, focusing on their content, reasoning, terminology, methodology, and findings. This comprehensive literature review offers educators practical information on efficiently utilizing smart learning environments and provides academics with significant insights and references for further exploration in the topic. This will facilitate the advancement and refinement of smart learning environments in higher education to more effectively address contemporary educational demands and enhance student learning performance.
Optimizing Breathing Patterns in Asthma Patients Through Purse Lip Breathing Technique
Authors: Fibriansari Rizeki Dwi , Imania Shafa Camila Say  , Zainal Abidin  
Published: February 2025

Asthma is a leading cause of global morbidity and mortality, accounting for 17.4% of deaths worldwide. As one of the top 10 non-communicable diseases, asthma significantly impacts patients and their families. Characterized by recurrent and reversible airway obstruction, asthma often leads to ineffective breathing patterns. This study explored the impact of pursed-lip breathing (PLB) therapy on reducing respiratory rate in asthma patients with ineffective breathing patterns at Dr. Haryoto Hospital, Lumajang. A case study design was employed from June 14 to June 18, 2024, involving a single asthma patient who met the criteria of dyspnea, abnormal breathing patterns, and the use of accessory respiratory muscles. Data collection included objective and subjective measurements using observation sheets, physical examination tools, and standard operational procedures. PLB therapy was administered over five days, with three daily sessions, each lasting 5 to 15 minutes. The patient, presenting with symptoms such as shortness of breath, chest tightness, prolonged expiratory phase, and abnormal breathing patterns, showed significant improvements following PLB therapy. Results indicated a reduction in respiratory rate by 6.76 breaths per minute, an increase in SpO2 by 3.44%, and a decrease in pulse rate by 51.62 beats per minute. PLB therapy effectively reduced respiratory effort, alleviated dyspnea, enhanced oxygen transport, and strengthened respiratory muscles. This study demonstrates that PLB therapy is an effective non-pharmacological intervention for managing asthma symptoms. Nurses are encouraged to incorporate PLB therapy into patient education to empower asthma patients to manage their symptoms independently.
A atuação do assistente social nas equipes multidisciplinares dos serviços oncológicos: uma revisão integrativa
Authors: Pinto Lana de Queiroz , Torres Camila Guimarães 
Published: February 2025

Esta pesquisa tem como objetivo analisar a atuação do Assistente Social nas equipes multidisciplinares de serviços oncológicos, especificamente busca entender a importância do papel desenvolvido por esse profissional na abordagem do paciente oncológico, sua relevância dentro das equipes, assim como o trabalho desenvolvido com pacientes e familiares. Este trabalho tem o intuito de ampliar o debate sobre tal tema, no âmbito das pesquisas na área de Serviço Social. Trata-se de uma pesquisa descritiva, com abordagem qualitativa, que utiliza como método a Revisão Integrativa de Literatura(1), sendo escolhidos dez artigos, publicados entre 2013 e 2023, encontrados através das palavras-chaves: equipe multidisciplinar, Serviço Social, serviços oncológicos, equipe de saúde, paciente oncológico e, diante disso, foi criada uma planilha para realizar uma análise mais criteriosa de cada artigo escolhido. Os resultados encontrados mostram que o assistente social desenvolve um papel fundamental dentro das equipes multidisciplinares dos diferentes serviços oncológicos, realizando o acolhimento e orientação não só aos pacientes, mas também aos familiares, o que pode contribuir para o enfrentamento das consequências do tratamento, sobretudo as repercussões sociais, que o diagnóstico e prognóstico trazem. Também foi possível observar uma escassez de produções acadêmicas sobre o tema em questão, sendo encontrados uma maior quantidade de artigos referentes à atuação profissional do assistente social com o paciente oncológico, com poucas produções que reflitam sobre a atuação dentro das equipes multidisciplinares nos serviços de oncologia.
The Influence of Active Types of Tourism on the Development of Territories and The Achievement of Esg Principles
Authors: Stepanova Diana , Nurgaliyeva Aliya , Bessonova Tatyana , Chernova Oxana , Litvinov Aleksandr , Aru Yuliya 
Published: February 2025

Objective: The purpose of the study is to detect opportunities for the development of different types of extreme tourism in Kazakhstan to promote opportunities for innovative change in the territories while respecting the principles of sustainable development.

Methods: The study employs qualitative and quantitative research methods, including surveys and analysis of existing literature.

Results: Authors devined the prospects for different types of extreme tourism in Kazakhstan. However, the driver of innovative change of territories in this area is only available with the improvement of staff qualification in the field of extreme tourism, the support of government programs to attract investment in the development of infrastructure, and the development of special environmental regulations to avert the risks of environmental problems that hinder the sustainable development of territories.

Conclusion: In today's highly competitive tourism business around the world, each country is searching for new ways to attract more tourists by developing infrastructure, building a knowledge economy, and stimulating the development of human capital. Implementing of the proposed measures will enhance Kazakhstan's competitive position in extreme tourism, drive economic growth, and ensure environmental sustainability.