bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photolytic Release of Butyric Acid from Oxygen‐ and Nitrogen‐Based Heteroaromatic Cages
Authors: Soares Ana M. S. , Piloto Ana M. , Hungerford Graham , Costa Susana P. G. , Gonçalves M. Sameiro T. 
Published: December 2011

AbstractIn order to develop butyric acid photoactive prodrugs, new heteroaromatic conjugates based on oxygen and nitrogen were synthesised and evaluated under irradiation at 254, 300, 350 and 419 nm. Light‐triggered uncaging of butyric acid from the corresponding heterocyclic cages was achieved with complete release of the drug in short times. Naphtho[2,3‐d]oxazole, naphtho[1,2‐d]oxazole, 3‐oxo‐3H‐benzo[f]benzopyran, 2‐oxo‐2H‐benzo[h]benzopyran and 6‐oxo‐6H‐benzopyrano[6,7‐d]oxazole conjugates were readily photolysed, and the best results were obtained for naphtho‐oxazoles at 254 and 300 nm and for 3‐oxo‐3H‐benzo[f]benzopyran, 2‐oxo‐2H‐benzo[h]benzopyran and 2‐methyl‐6‐oxo‐6H‐benzopyrano[6,7‐d]oxazole at 350 nm. 3‐Oxo‐3H‐benzo[f]benzopyran also afforded good results at 419 nm. The photophysical processes involved were further elucidated by the use of time‐resolved fluorescence techniques.
ETV6 rearrangements are recurrent in myeloid malignancies and are frequently associated with other genetic events
Authors: Haferlach Claudia , Bacher Ulrike , Schnittger Susanne , Alpermann Tamara , Zenger Melanie , Kern Wolfgang , Haferlach Torsten 
Published: December 2011

AbstractETV6 (TEL) rearrangements are favorable in pediatric acute lymphoblastic leukemia but are less well characterized in myeloid malignancies. We investigated 9,550 patients with myeloid disorders for ETV6 rearrangements by chromosome banding analysis and interphase fluorescence in situ hybridization. ETV6 rearrangements were identified in 51 of 9,550 (0.5%) patients (range, 19.2–85.3 years). Frequencies were in detail: acute myeloid leukemia (AML): 40 of 3,798, 1.1%; myelodysplastic syndromes (MDS): 6 of 3,375, 0.2%; myeloproliferative neoplasms (MPNs): 5 of 1,720, 0.3%; MDS/MPN: 0 of 210; and chronic myelomonocytic leukemia: 0 of 447. Thirty‐three different partner bands of ETV6 were identified, and most were recurrent: 3q26 (n = 10), 5q33 (n = 4), 17q11 (n = 3), 22q12 (n = 3), 5q31 (n = 2), and 2q31 (n = 2). Additional chromosomal abnormalities were identified in 29 of 51 (57%) ETV6 rearranged cases. In AML, ETV6 rearrangements were frequently associated with NPM1 (9/39, 23%) and RUNX1 mutations (6/31, 19%). The FAB M0 subtype was more frequent in ETV6 rearranged de novo AML than other AML (P < 0.001); expression of CD7 and CD34 by immunophenotyping was higher in ETV6 rearranged AML compared with other subgroups. Survival of 29 ETV6 rearranged de novo AML was compared with 818 AML from other cytogenetic subgroups. Median overall and event‐free survival of ETV6 rearranged cases was similar to the intermediate‐risk cohort (26.3 vs. 62.2 months and 14.0 vs. 15.4 months) defined according to Medical Research Council criteria. Our study confirms the variety of ETV6 rearrangements in AML, MDS, and MPNs often in association with other genetic events. Prognosis of ETV6 rearranged de novo AML seems to be intermediate, which should be independently confirmed. © 2011 Wiley Periodicals, Inc.
CGH arrays compared for DNA isolated from formalin‐fixed, paraffin‐embedded material
Authors: Krijgsman Oscar , Israeli Danielle , Haan Josien C. , van Essen Hendrik F. , Smeets Serge J. , Eijk Paul P. , M. Steenbergen Renske D. , Kok Klaas , Tejpar Sabine , Meijer Gerrit A. , Ylstra Bauke 
Published: December 2011

AbstractFormalin‐fixed, paraffin‐embedded (FFPE) archival tissue is an important source of DNA material. The most commonly used technique to identify copy number aberrations from chromosomal DNA in tumorigenesis is array comparative genomic hybridization (aCGH). Although copy number analysis using DNA from FFPE archival tissue is challenging, several research groups have reported high quality and reproducible DNA copy number results using aCGH. Aim of this study is to compare the commercially available aCGH platforms suitable for high‐resolution copy number analysis using FFPE‐derived DNA. Two dual channel aCGH platforms (Agilent and NimbleGen) and a single channel SNP‐based platform (Affymetrix) were evaluated using seven FFPE colon cancer samples, and median absolute deviation (MAD), deflection, signal‐to‐noise ratio, and DNA input requirements were used as quality criteria. Large differences were observed between platforms; Agilent and NimbleGen showed better MAD values (0.13 for both) compared with Affymetrix (0.22). On the contrary, Affymetrix showed a better deflection of 0.94, followed by 0.71 for Agilent and 0.51 for NimbleGen. This resulted in signal‐to‐nose ratios that were comparable between the three commercially available platforms. Interestingly, DNA input amounts from FFPE material lower than recommended still yielded high quality profiles on all platforms. Copy number analysis using DNA derived from FFPE archival material is feasible using all three high‐resolution copy number platforms and shows reproducible results, also with DNA input amounts lower than recommended. © 2011 Wiley Periodicals, Inc.
The effect of 3 versus 6 years of Zoledronic acid treatment of osteoporosis: A randomized extension to the HORIZON-Pivotal Fracture Trial (PFT)
Authors: Black Dennis M , Reid Ian R , Boonen Steven , Bucci-Rechtweg Christina , Cauley Jane A , Cosman Felicia , Cummings Steven R , Hue Trisha F , Lippuner Kurt , Lakatos Peter , Leung Ping Chung , Man Zulema , Martinez Ruvie Lou Maria , Tan Monique , Ruzycky Mary Ellen , Su Guoqin , Eastell Richard 
Published: December 2011

Abstract
Zoledronic acid 5 mg (ZOL) annually for 3 years reduces fracture risk in postmenopausal women with osteoporosis. To investigate long-term effects of ZOL on bone mineral density (BMD) and fracture risk, the Health Outcomes and Reduced Incidence with Zoledronic acid Once Yearly–Pivotal Fracture Trial (HORIZON-PFT) was extended to 6 years. In this international, multicenter, double-blind, placebo-controlled extension trial, 1233 postmenopausal women who received ZOL for 3 years in the core study were randomized to 3 additional years of ZOL (Z6, n = 616) or placebo (Z3P3, n = 617). The primary endpoint was femoral neck (FN) BMD percentage change from year 3 to 6 in the intent-to-treat (ITT) population. Secondary endpoints included other BMD sites, fractures, biochemical bone turnover markers, and safety. In years 3 to 6, FN-BMD remained constant in Z6 and dropped slightly in Z3P3 (between-treatment difference = 1.04%; 95% confidence interval 0.4 to 1.7; p = 0.0009) but remained above pretreatment levels. Other BMD sites showed similar differences. Biochemical markers remained constant in Z6 but rose slightly in Z3P3, remaining well below pretreatment levels in both. New morphometric vertebral fractures were lower in the Z6 (n = 14) versus Z3P3 (n = 30) group (odds ratio = 0.51; p = 0.035), whereas other fractures were not different. Significantly more Z6 patients had a transient increase in serum creatinine &gt;0.5 mg/dL (0.65% versus 2.94% in Z3P3). Nonsignificant increases in Z6 of atrial fibrillation serious adverse events (2.0% versus 1.1% in Z3P3; p = 0.26) and stroke (3.1% versus 1.5% in Z3P3; p = 0.06) were seen. Postdose symptoms were similar in both groups. Reports of hypertension were significantly lower in Z6 versus Z3P3 (7.8% versus 15.1%, p &lt; 0.001). Small differences in bone density and markers in those who continued versus those who stopped treatment suggest residual effects, and therefore, after 3 years of annual ZOL, many patients may discontinue therapy up to 3 years. However, vertebral fracture reductions suggest that those at high fracture risk, particularly vertebral fracture, may benefit by continued treatment. (ClinicalTrials.gov identifier: NCT00145327). © 2012 American Society for Bone and Mineral Research
Mourning dove reporting probabilities for web‐address versus toll‐free bands
Authors: Sanders Todd A. , Otis David L. 
Published: December 2011

AbstractFederal migratory bird bands have been inscribed with a postal address and toll‐free telephone number (toll‐free bands) since 1995 for their reporting, but in 2007 the postal mail address was replaced with an internet address (web‐address bands). The reporting rate of web‐address bands is unknown, and knowledge of band reporting probabilities is an integral part of bird band‐recovery studies designed to obtain unbiased estimates of harvest rates and recovery rates if use of band types differs across space and time. We estimated web‐address band reporting probabilities for mourning doves (Zenaida macroura) in the United States by comparing the relative recovery rate (ratio) of web‐address to toll‐free bands and applying this as an adjustment factor to the known reporting probabilities of toll‐free bands. Cooperators banded 132,386 doves representing 57,982 (44%) web‐address and 74,404 (56%) toll‐free bands in July and August during 2008–2010 across 34 states, 12 regions, and 3 management units. Of the birds banded, 4,642 (3.5%) were direct recoveries, as a result of being shot, and all but 3 were reported via telephone or internet. Nationally, internet reporting accounted for 16.3% of toll‐free bands and 42.9% of web‐address bands recovered. Web‐address bands had a greater recovery rate than toll‐free bands (ratio = 1.081, SE = 0.027). We found some evidence of spatial variation in ratio estimates at management unit and regional scales, but the variation was primarily at the regional level where it was not great (range = 1.015–1.213) and statistical support for this variation was not particularly strong (SE = 0.129). Nationally, the web‐address band reporting probability was 0.535 (SE = 0.021), an absolute increase of 0.040 compared to the reporting probability of toll‐free bands. The additional reporting probability of web‐address bands relative to toll‐free bands must be accounted for in band‐recovery studies used to obtain estimates of harvest rates and recovery rates if use of band types differs across space and time for mourning doves and possibly other species. © 2011 The Wildlife Society.
Variations in elk aggregation patterns across a range of elk population sizes at Wall Creek, Montana
Authors: Proffitt Kelly M. , Gude Justin A. , Shamhart Julee , King Fred 
Published: December 2011

AbstractIn the Greater Yellowstone Ecosystem, growing concern over increasing rates of brucellosis seroprevalence in wildlife has challenged wildlife managers to develop strategies for minimizing the potential for pathogen exchange within and between wildlife populations. Recent evidence suggests that increases in elk seroprevalence may be associated with increasing elk densities and/or increasing size of elk aggregations. However, the interactions between elk population density, landscape factors, and elk aggregation patterns are not well‐understood, making appropriate management responses challenging. Using a unique, long‐term elk aggregation dataset collected across a wide range of elk population sizes, we investigated relationships between elk population size, landscape factors, and elk aggregation responses (group size and group density) with goals of clarifying how changes in elk population size may affect elk aggregation patterns. Overall, landscape attributes and weather had a stronger influence on elk aggregation patterns than factors such as elk population size that are within management control. We found little evidence that elk population size affected mean elk group sizes, but we did find evidence that the size and density of the largest elk aggregations increased as elk population size increased. We also found some evidence that group densities increased following the establishment of wolves. However, across the relatively wide range of elk population sizes observed in this study, only modest changes in elk group density were observed, suggesting that dramatic reductions in population sizes would be necessary to produce measureable reductions in elk group density to affect frequency‐dependent transmission. Management actions designed to lower disease transmission are likely to negatively affect other objectives related to elk management and conservation. We therefore suggest that a first step in managing disease transmission risk is agreement among stakeholders interested in elk management of all objectives related to elk management, including acknowledgment that disease transmission is undesirable. © 2011 The Wildlife Society.
Identification of a novel biomarker gene set with sensitivity and specificity for distinguishing between allograft rejection and tolerance#*
Authors: Xie Lin , Ichimaru Naotsugu , Morita Miwa , Chen Jiajie , Zhu Ping , Wang Jihong , Urbanellis Peter , Shalev Itay , Nagao Shizuko , Sugioka Atsushi , Zhong Liang , Nonomura Norio , Takahara Shiro , Levy Gary A. , Li Xiao-Kang 
Published: December 2011

Abstract
Here we examined whether the expression of a novel immunoregulatory gene set could be used to predict outcomes in murine models of rapamycin-induced cardiac tolerance, spontaneous hepatic tolerance, and cardiac rejection. The expression of the immunoregulatory gene set was assessed with the GeXP multiplex reverse-transcription polymerase chain reaction (RT-PCR) analysis system, and it was correlated to the pathological and biochemical parameters of the allografts. In rejecting cardiac grafts, the increased expression of an inflammatory set of genes, which included CD45, CD4, CD25, suppressor of cytokine signaling 2, cytotoxic T lymphocyte–associated protein 4 (CTLA4), selectin lymphocyte, interferon-γ (IFN-γ), programmed cell death 1 (Pdcd1), and granzyme B (Gzmb), was seen 8 days after transplantation along with histological evidence of severe allograft rejection. In tolerant cardiac allografts, the expression of fibrinogen-like protein 2 (Fgl2), Pdcd1, killer cell lectin-like receptor G1 (Klrg1), CTLA4, and lymphocyte-activation gene 3 was associated with tolerance. In a model of liver allograft tolerance, the increased expression of lectin galactose-binding soluble 1, Fgl2, CD39, phosphodiesterase 3B, Klrg1, forkhead box P3 (Foxp3), and transforming growth factor β as well as the inflammatory set of genes was observed 8 to 14 days after transplantation (ie, when there was severe inflammatory injury). At a later time when the liver allografts had been fully accepted and were histologically normal, the expression of the inflammatory set of genes returned to the baseline, but the expression of the tolerogenic set of genes was still increased. Genes that were expressed in tolerant cardiac and liver allografts included Fgl2, Klrg1, and Foxp3, whereas genes associated with rejection included CD25, Gzmb, and IFN-γ. Our data indicate that monitoring the graft expression of a novel biomarker gene set with the GeXP multiplex RT-PCR analysis system may allow differentiation between rejection and tolerance. Liver Transpl 18:444–454, 2012. © 2012 AASLD.
Milder phenotype of congenital muscular dystrophy in a novel POMT1 mutation
Authors: Al‐Zaidy Samiah A. , Baskin Berivan , Hawkins Cynthia , Yoon Grace , Ray Peter N. , Vajsar Jiri 
Published: December 2011

AbstractIntroduction: Congenital muscular dystrophies (CMD) with hypoglycosylated α‐dystroglycan due to POMT1 mutations are associated with clinical phenotypes that vary in severity.Methods: We describe a patient with congenital hypotonia, generalized weakness, elevated creatine kinase (CK), and normal brain imaging. Results: Histochemical analysis of the index case's muscle showed deficiency of glycosylated α‐dystroglycan and secondary merosin deficiency. Genetic testing revealed a novel mutation in exon 20 of the POMT1 gene. Conclusions: Our patient's milder form of CMD adds to the emerging evidence of an expanding phenotype caused by POMT1 mutations. The histopathological findings of the muscle biopsy in this case support the need for careful clinical, genetic, and histochemical diagnostic interpretation. Muscle Nerve 45: 752–755, 2012
Synthesis of Bis[N,N′‐(alkylamideethyl)ethyl] Triethylenediamine Bromide Surfactants and Their Oilfield Application Investigation
Authors: Zhou Ming , Zhao Jinzhou , Hu Xingqi 
Published: December 2011

AbstractBis[N,N′‐(alkylamideethyl)ethyl] triethylenediamine surfactants are quaternary ammonium salt Gemini surfactants with amide, which are synthesized from fatty acid (dodecanoic, hexadecanoic, tetradecanoic and octadecanoic) methyl esters, triethylene tetramine and ethyl bromide. The chemical structures of the prepared compounds were characterized by elemental analysis, FTIR and 1H‐NMR spectra, melting point and Krafft point. Several properties of the synthesized surfactants were studied including surface tension, critical micelle concentration, interfacial tension, emulsification power, salt effect, corrosion inhibition efficiency and biological activity. The results show that the surface activity, critical micelle concentration and interfacial activity are correlated to their chemical structures. The emulsification power measurements of these surfactants show their low emulsifying tendency towards Tazhong's crude oil from Tarim Oilfield. The synthesized surfactants also exhibit high biocidal activity towards Gram‐positive and Gram‐negative bacteria and fungi. This activity increases with the increase of alkyl chain length. The corrosion measurement of these surfactants in acidic media with a weight loss technique show good protection of mild steel alloys against acidic environments. These properties suggest that the synthesized compounds have potential for application in the oilfield area.
Early Paleozoic tectonics and geodynamics of Central Asia: role of mantle plumes
Authors: Dobretsov N.L. 
Published: December 2011

Abstract
There were two key stages in the history of Paleozoids that formed in the place of the Paleoasian ocean, one in the Cambrian–Ordovician and the other in the Permian–Triassic. Both time spans were characterized by a combination of similar geodynamic, magmatic, and geomagnetic events: closure and opening of oceanic basins, intense plume magmatism associated with Earth’s core cooling, and absence of geomagnetic reversals (superchrons). Three superchrons about 490–460, 260–300, and 124–86 Ma correlate with major events of plume magmatism. Plume reconstructions have to be updated for the period 490–460 Ma, which corresponded to the third superchron and was marked by ocean opening. The previous superplume, about 800–740 Ma, requires further justification but fits the global periodicity with 240 Ma major cycles and smaller ones of 120 (or also 30) Ma.
In the Late Cambrian–Ordovician, large-scale accretion and collision events acted, in similar tectonic settings, upon the vast territory that currently extends from the Polar Urals to Lake Baikal (and was times larger in the past). As a result, Gondwanian microcontinents (Kokchetav, Altai–Mongolia, Tuva–Mongolia, etc.) and island arcs joined into the Kazakhstan–Tuva–Mongolia system. The formation of the Late Cambrian–Ordovician orogen in Central Asia was synchronous with opening of the Ural, Ob–Zaisan, Turkestan, and Paleotethys oceans. The plume pulses (520–500 and 490–460 Ma) may have been responsible for opening of new oceans, accelerated amalgamation of terranes, and synchronicity in geodynamic events from the Urals to Transbaikalia.
Problems of geodynamics, tectonics, and metallogeny of orogens
Authors: Dobretsov N.L. , Buslov M.M. 
Published: December 2011

Abstract
This is an overview of papers published in the present volume of Russian Geology and Geophysics (Geologiya i Geofizika), a special issue that covers presentations at the International Conference “Geodynamic Evolution, Tectonics, and Metallogeny of Orogens”, held on 28–30 June 2010 in Novosibirsk (http://altay2010.igm.nsc.ru). The workshop concerned the general evolution of the Central Asian orogenic system, with a special focus on continental growth, history of oceans and continental margins, and role of plumes in accretionary-collisional tectonics and metallogeny. The discussed papers are grouped in three sections: 1. General issues of geodynamics and geodynamic evolution; 2. Role of mantle plumes in tectonics, magmatism, and metallogeny; 3. Regional tectonic and geodynamic problems of Asia.
The synthesis of data reported at the workshop demonstrates critical importance of mantle plumes for the evolution of the Paleoasian ocean and for orogenic processes in Central Asia.
In addition to three large pulses of continental growth at about 2900–2700, 1900–1700, and 900–700 Ma, three orogenic stages have been distinguished in the geological history of Eurasia: Late Cambrian–Ordovician (510–470 Ma), Late Devonian–Early Carboniferous (380–320 Ma), and Permian–Triassic (285–230 Ma). In the evolution of the Central Asian orogen, these stages were associated with events of ultramafic-mafic and bimodal plume magmatism which promoted translithospheric strike-slip faulting. Plume magmatism was an active agent in ocean opening when the Paleotethys, Ural, Ob–Zaisan, and Turkestan basins appeared while the Late Cambrian–Ordovician orogen was forming in Central Asia (North Kazakhstan, Altai–Sayan, Tuva, and Baikal areas). Closure of the Ob–Zaisan ocean and collision of the Kazakhstan–Baikal continent with Siberia in the Late Devonian–Early Carboniferous was coeval with the maximum opening of the Turkestan ocean, possibly, as a consequence of plume activity. The Tarim (285–275 Ma) and Siberian (250–230 Ma) superplume events corresponded in time to closure of the Ural ocean and opening of the Meso- and Neotethys, as well as to major metallogenic events.
Initial construction of a maladaptive personality trait model and inventory for DSM-5
Authors: Krueger R. F. , Derringer J. , Markon K. E. , Watson D. , Skodol A. E. 
Published: December 2011

BackgroundDSM-IV-TR suggests that clinicians should assess clinically relevant personality traits that do not necessarily constitute a formal personality disorder (PD), and should note these traits on Axis II, but DSM-IV-TR does not provide a trait model to guide the clinician. Our goal was to provide a provisional trait model and a preliminary corresponding assessment instrument, in our roles as members of the DSM-5 Personality and Personality Disorders Workgroup and workgroup advisors.MethodAn initial list of specific traits and domains (broader groups of traits) was derived from DSM-5 literature reviews and workgroup deliberations, with a focus on capturing maladaptive personality characteristics deemed clinically salient, including those related to the criteria for DSM-IV-TR PDs. The model and instrument were then developed iteratively using data from community samples of treatment-seeking participants. The analytic approach relied on tools of modern psychometrics (e.g. item response theory models).ResultsA total of 25 reliably measured core elements of personality description emerged that, together, delineate five broad domains of maladaptive personality variation: negative affect, detachment, antagonism, disinhibition, and psychoticism.ConclusionsWe developed a maladaptive personality trait model and corresponding instrument as a step on the path toward helping users of DSM-5 assess traits that may or may not constitute a formal PD. The inventory we developed is reprinted in its entirety in the Supplementary online material, with the goal of encouraging additional refinement and development by other investigators prior to the finalization of DSM-5. Continuing discussion should focus on various options for integrating personality traits into DSM-5.