bluuebunny/crossref_metadata_2025_split huggingface dataset:
A proposal to teach medical students how to use interpreters
Authors: Thomas Kyle , Jacobs Nicole , Lopez Vera Alexandra 
Published: June 2024

Abstract
Introduction
Medical interpreters are crucial to ensure fair and high-quality healthcare for patients with limited English proficiency (LEP). Despite the need to use high-quality medical interpreters to communicate with LEP patients, medical schools often do not adequately educate their students on how to work with interpreters.

Aims
This study seeks to investigate the efficacy of using peer-assisted learning to teach medical students how to properly use medical interpreters. Moreover, the study strives to elucidate if an interactive peer-led model can be an effective teaching modality to train medical students about the basics of using medical interpreters.

Methods
A pre- and post-training design was utilized to investigate the efficacy of peer-assisted learning in teaching medical students how to use interpreters. Second year medical students led a two-part workshop consisting of the following: (1) a didactic training session and (2) a practical session where learners interacted with Spanish-speaking standardized patients through an interpreter. Pre-training and post-training responses to survey questions were analyzed to determine changes in student comfort, confidence, and knowledge of best practices when using a medical interpreter.

Results
There was a statistically significant increase in comfort and confidence with using interpreters after receiving peer-assisted training.

Conclusions
A peer-led didactic training followed by an interactive training session can increase student comfort and confidence with using medical interpreters in clinical settings. Peer-assisted-learning may be an effective way to teach some of the best practices of using medical interpreters.
Cost analysis review of a patient navigator and fecal immunochemical testing on colorectal cancer screening in an underserved population
Authors: Fiske Hannah W. , Monteiro Joao Filipe G. , Hilliard Ross W. , Grisson Ricky , Holloway Marlaydis , Feliz Carrie Bridges , Rich Harlan 
Published: June 2024

Abstract
Background
Colorectal cancer screening is a critical preventative service and part of routine patient care, yet a substantial portion of the population fails to undergo recommended screening.

Aims
To investigate the impact and cost-effectiveness of a patient navigator on colorectal cancer screening via fecal immunochemical testing.

Methods
Design: retrospective analysis investigating structured outreach via a dedicated patient navigator. Location: Center for Primary Care, Rhode Island Hospital’s primary safety-net clinic for adult patients in Providence, Rhode Island. Timing: the study ran between 01/2017 and 12/2021, with the intervention introduced 01/2021.

Results
This study included 3542 patients. The intervention improved completion rates from 64.7 to 74.5% at 1 month (HR 1.12, 95%CI [1.003–1.243]), 73.7% to 90.1% at 3 months (1.28[1.156–1.410]), and 87.8 to 98.8% at 1 year (1.36 [1.239–1.498]). Overall, completion rates were improved by 38.5% (1.39[1.260–1.522]). Total cost of colorectal cancer screening per patient was decreased by $874.18 in the post-intervention group ($72.0 ± 383.3 vs. $946.1 ± 1873.5, p < 0.0001).

Conclusions
In this retrospective analysis, our targeted intervention improved fecal immunochemical testing kit return rates and significantly reduced screening costs. The addition of a dedicated patient navigator is critical to ensuring compliance with screening guidelines, particularly for deprived and/or medically underserved populations. Health care systems, insurance companies and payers, and state health departments should actively and consistently support this role, as it will allow fecal immunochemical testing to reach and risk-stratify more patients, increasing the yield of colonoscopy for detecting advanced neoplasia and cancer and subsequently reducing pressure on endoscopy centers.
The Importance of Accounting for Landscape Position When Investigating Grasslands: A Multidisciplinary Characterisation of a California Coastal Grassland
Authors: Rowley Mike C. , Falco Nicola , Pegoraro Elaine , Dafflon Baptiste , Gerlein‐Safdi Cynthia , Wu Yuxin , Castanha Cristina , Peña Jasquelin , Nico Peter S. , Torn Margaret S. 
Published: June 2024

AbstractGrasslands are one of the most common land‐cover types, providing important ecosystem services globally, yet few studies have examined grassland critical‐zone functioning throughout hillslopes. This study characterised a coastal grassland over a small hillslope at Point Reyes National Seashore, California, using multidisciplinary techniques, combining remotely‐sensed, geophysical, plant, and soil measurements. Clustering techniques delineated the study area into four landscape zones, up‐, mid‐, and down‐slope, and a bordering riparian ecotone, which had distinct environmental properties that varied spatially across the site, with depth, and time. Soil moisture increased with depth and down slope towards a bordering riparian zone, and co‐varied with soil CO2 flux rates both spatially and temporally. This highlighted three distinct controls of soil moisture on soil respiration: CO2 fluxes were inhibited by high moisture content in the down‐slope during the wet winter months, and converged across landscape positions in the dry summer months, while also displaying post‐rain pulses. The normalised difference vegetation index (NDVI) ranged from 0.32 (September)–0.80 (April) and correlated positively with soil moisture and aboveground biomass, moving down slope. Yet, NDVI, aboveground biomass, and soil moisture were not correlated to soil organic carbon (SOC) content (0.4%–4.5%), which was highest in the mid‐slope. The SOC content may instead be linked to shifts in dominant grassland species and their rhizosphere properties with landscape position. This multidisciplinary characterisation highlighted significant heterogeneity in grassland properties with landscape position, and demonstrated an approach that could be used to characterise other critical‐zone environments on hillslopes.
In Memoriam of Editor Jennifer L. Gannon
Authors: Lugaz Noé , Knipp Delores , Morley Steven K. , Liu Huixin , Hapgood Mike , Carter Brett , Zou Shasha , Lei Jiuhou , Welling Dan 
Published: June 2024

AbstractDr. Jennifer Gannon passed away suddenly on 2024 May 2 in Greenbelt, MD. Dr. Gannon had served as an editor for the Space Weather journal since April 2019, and she was the longest‐serving editor on the current board, having started under the previous editor‐in‐chief, Dr. Delores Knipp.
Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors
Authors: Papp Orsolya , Jordán Viktória , Hetey Szabolcs , Balázs Róbert , Kaszás Valér , Bartha Árpád , Ordasi Nóra N. , Kamp Sebestyén , Farkas Bálint , Mettetal Jerome , Dry Jonathan R. , Young Duncan , Sidders Ben , Bulusu Krishna C. , Veres Daniel V. 
Published: June 2024

AbstractCombination therapy is well established as a key intervention strategy for cancer treatment, with the potential to overcome monotherapy resistance and deliver a more durable efficacy. However, given the scale of unexplored potential target space and the resulting combinatorial explosion, identifying efficacious drug combinations is a critical unmet need that is still evolving. In this paper, we demonstrate a network biology-driven, simulation-based solution, the Simulated Cell™. Integration of omics data with a curated signaling network enables the accurate and interpretable prediction of 66,348 combination-cell line pairs obtained from a large-scale combinatorial drug sensitivity screen of 684 combinations across 97 cancer cell lines (BAC = 0.62, AUC = 0.7). We highlight drug combination pairs that interact with DNA Damage Response pathways and are predicted to be synergistic, and deep network insight to identify biomarkers driving combination synergy. We demonstrate that the cancer cell ‘avatars’ capture the biological complexity of their in vitro counterparts, enabling the identification of pathway-level mechanisms of combination benefit to guide clinical translatability.
The impact of PD-1 inhibitors on prognosis in unresectable hepatocellular carcinoma treated with TACE and lenvatinib: a retrospective study
Authors: Ding Zongren , Fang Guoxu , Tang Yanyan , Zeng Yongyi 
Published: June 2024

AbstractOur aim was to explore whether programmed death receptor-1 (PD-1) inhibitors would improve the prognosis of unresectable hepatocellular carcinoma (HCC) treated with transarterial chemoembolization (TACE) plus lenvatinib. In this single-center retrospective study, patients with unresectable HCC who underwent TACE and were administered lenvatinib with or without PD-1 inhibitors were enrolled and divided into the TACE + lenvatinib group and TACE + lenvatinib + PD-1 group. Overall survival (OS), progression-free survival (PFS) and tumor response were assessed by the Response Evaluation Criteria in Solid Tumors (RECIST v1.1 and mRECIST). Treatment-related adverse events (AEs) were evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE, version 5.0). In total, 35 eligible patients with unresectable HCC were included; 82.9% of patients had Hepatitis B virus (HBV) infection, and 88.6% of patients had liver cirrhosis. A total of 88.6% of patients had multiple tumors, and the median diameter of the largest tumor was 10.1 cm. A total of 14.3% of patients had extrahepatic metastasis, and 51.4% of patients had portal vein tumor thrombus. The percentages of BCLC stages A, B and C were 5.7%, 28.6% and 65.7%, respectively. There were 16 patients in the TACE + lenvatinib group and 19 patients in the TACE + lenvatinib + PD-1 group. The median follow-up time was 7.7 months (ranging from 1.7 to 31.6 months). Neither group reached the median overall survival. Under RECIST v1.1 criteria, the median PFS was 10.4 and 7.9 months in the TACE + lenvatinib and TACE + lenvatinib + PD-1 groups (HR, 1.13; 95% CI 0.45–2.84; p = 0.80), the objective response rates (ORR) were 31.3% and 31.6% (p > 0.05), and the disease control rates (DCR) were 93.8% and 78.9% (p > 0.05), respectively. Under mRECIST criteria, the median PFS was 10.4 and 10.1 months (HR, 0.98; 95% CI 0.38–2.54, p = 0.97), the ORR was 62.5% and 63.2% (p > 0.05), and the DCR was 93.8% and 73.7% (p > 0.05), respectively. Overall, AEs were relatively similar between the two groups. PD-1 inhibitors did not improve the PFS and tumor response of unresectable HCC treated with TACE plus lenvatinib. Hepatitis B infection, liver cirrhosis, portal vein tumor thrombus, multiple tumors and large tumor diameter may be potential factors that affect the efficacy of PD-1 inhibitors but need further validation.
Complete chloroplast genomes and phylogenetic relationships of Pedicularis chinensis and Pedicularis kansuensis
Authors: Wang Tao , Li Xiuzhang , Tang Chuyu , Cao Zhengfei , He Hui , Ma Xiaoping , Li Yuling , De Kejia 
Published: June 2024

AbstractThe complete cp genomes of Pedicularis chinensis (GenBank accession number: OQ587614) and Pedicularis kansuensis (GenBank accession number: OQ587613) were sequenced, assembled, and annotated. Their chloroplast (cp) genome lengths were 146,452 bp, and 146,852 bp, respectively; 120 and 116 genes were identified, comprising 75 and 72 protein-coding genes (PCGs), 37 and 36 transfer RNA (tRNA) genes, and 8 and 8 ribosomal RNA (rRNA) genes, for P. chinensis and P. kansuensis, respectively. A simple sequence repeat (SSR) analysis revealed that the repetitive sequences were mainly composed of mononucleotide repeats (A/T motif) and dinucleotide repeats (AT/TA motif). Comparative genomics identified several variant genes (rpl22, rps19, rpl12, ycf1, trnH, psbA, and ndhH) and variant regions (trnS-GGA, trnV-UAC, ndhJ-trnV, ycf4-cemA, ndhE-nhdG, and rpl32-trnL) with a high Pi, indicating the potential to serve as deoxyribo nucleic acid (DNA) barcodes for Pedicularis species identification. The results show that the cp genomes of P. chinensis and P. kansuensis were the same as those of other plants in Pedicularis, with different degrees of AT preference for codons. Large differences in the number of SSRs and the expansion of the inverted repeat (IR) region showed strong variability and interspecific differentiation between these two species and other species represented in the genus Pedicularis. A phylogenetic analysis showed that P. kansuensis had the closest relationship with P. oliveriana, and P. chinensis had the closest relationship with P. aschistorhyncha. These results will facilitate the study of the phylogenetic classification and interspecific evolution of Pedicularis plants.
Volume control strategy and patient survival in sepsis-associated acute kidney injury receiving continuous renal replacement therapy: a randomized controlled trial with secondary analysis
Authors: Park Cheol Ho , Koh Hee Byung , Lee Jin Hyeog , Jung Hui-Yun , Ha Joohyung , Kim Hyung Woo , Park Jung Tak , Han Seung Hyeok , Kang Shin-Wook , Yoo Tae-Hyun 
Published: June 2024

AbstractOptimal strategy for volume control and the clinical implication of achieved volume control are unknown in patients with sepsis-associated acute kidney injury (AKI) receiving continuous renal replacement therapy (CRRT). This randomized controlled trial aimed to compare the survival according to conventional or bioelectrical impedance analysis (BIA)-guided volume control strategy in patients with sepsis-associated AKI receiving CRRT. We also compared patient survival according to achieved volume accumulation rate ([cumulative fluid balance during 3 days × 100]/fluid overload measured by BIA at enrollment) as a post-hoc analysis. We randomly assigned patients to conventional volume control strategy (n = 39) or to BIA-guided volume control strategy (n = 34). There were no differences in 28-day mortality (HR, 1.19; 95% CI, 0.63–2.23) or 90-day mortality (HR, 0.99; 95% CI 0.57–1.75) between conventional and BIA-guided volume control group. In the secondary analysis, achieved volume accumulation rate was significantly associated with patient survival. Compared with the achieved volume accumulation rate of ≤  − 50%, the HRs (95% CIs) for the risk of 90-day mortality were 1.21 (0.29–5.01), 0.55 (0.12–2.48), and 7.18 (1.58–32.51) in that of  − 50–0%, 1–50%, and > 50%, respectively. Hence, BIA-guided volume control in patients with sepsis-associated AKI receiving CRRT did not improve patient outcomes. In the secondary analysis, achieved volume accumulation rate was associated with patient survival.
Warm-up music and low-dose caffeine enhance the activity profile and psychophysiological responses during simulated combat in female taekwondo athletes
Authors: Delleli Slaheddine , Ouergui Ibrahim , Messaoudi Hamdi , Bridge Craig , Ardigò Luca Paolo , Chtourou Hamdi 
Published: June 2024

AbstractTo assess the effects of warm-up music and low dose (3 mg·kg−1) of caffeine (CAF) on female taekwondo athlete’s activity profile and psychophysiological responses during simulated combat. In a double-blinded, randomized, crossover study, 16 female athletes participated in simulated combats under one control and 5 experimental conditions [i.e., CAF alone (CAF), placebo alone (PL), CAF with music (CAF + M), PL with music (PL + M), and no supplement with music (M)]. After warming-up, athletes rated their felt arousal (FAS). Mean (HRmean) and peak (HRpeak) heart rate values were determined for each combat. After fighting, athletes rated their perceived exertion (RPE), feeling scale (FS), FAS, and physical enjoyment (PACES). Time-motion and technical-tactical variables were analyzed. CAF + M induced shorter skip and pause time, while attack time increased compared to other conditions (p < 0.05). Moreover, CAF + M increased single attacks, combined attacks, counter-attacks (p < 0.001), and defensive actions (p < 0.05) than other conditions. HRmean and HRpeak were lower under CAF + M than other conditions (p < 0.05). Additionally, higher FAS post-combat, FS, and PACES were observed under CAF + M, while RPE was lower (except CAF condition) compared to the other conditions (p < 0.05.Using CAF with warm-up music may increase combat cadence and improve the psychological state in female athletes more effectively than either strategy alone.
RBC transfusion and necrotizing enterocolitis in very preterm infants: a multicenter observational study
Authors: Dang Dan , Gu Xinyue , Jiang Siyuan , Li Wenli , Zhou Wenhao , Cao Yun , Lee Shoo Kim , Wu Hui , Zhou Jianguo ,   Chinese Neonatal Network (CHNN),   Group Information of the Chinese Neonatal Network, Lee Shoo Kim , Chen Chao , Du Lizhong ,   Site principle investigators of the Chinese Neonatal Network, Chen Xiuyong , Zhang Huyan , Tian Xiuying , Shi Jingyun , Li Zhankui , Yang Chuanzhong , Liu Ling , Yang Zuming , Fu Jianhua , Ji Yong , Chen Dongmei , Yang Changyi , Chen Rui , Peng Xiaoming , Shan Ruobing , Han Shuping , Wu Hui , Wang Lili , Wei Qiufen , Li Mingxia , Dai Yiheng , Jiang Hong , Kang Wenqing , Gong Xiaohui , Zhong Xiaoyun , Shi Yuan , Jiang Shanyu , Sun Bing , Li Long , Lin Zhenlang , Liu Jiangqin , Pan Jiahua , Xia Hongping , Li Xiaoying , Xu Falin , Qiu Yinping , Ma Li , Yang Ling , He Xiaori , Li Yanhong , Zhuang Deyi , Zhang Qin , Dong Wenbin , Sun Jianhua , Liang Kun , Wang Huaiyan , Feng Jinxing , Chen Liping , Lin Xinzhu , Jiang Chunming , Nie Chuan , Zeng Linkong , Hei Mingyan , Zhu Hongdan , Mi Hongying , Yin Zhaoqing , Song Hongxia , Wang Hongyun , Li Dong , Gao Yan , Wang Yajuan , Dai Liying , Zhang Liyan , Li Yangfang , Zhang Qianshen , Ding Guofang , Wang Jimei , Chen Xiaoxia , Wang Zhen , Tang Zheng , Ma Xiaolu , Zhang Xiaomei , Zhang Xiaolan , Wu Fang , Chen Yanxiang , Wu Ying , Ting Joseph 
Published: June 2024

AbstractThe causal relationship between Packed red blood cell (RBC) transfusion and necrotizing enterocolitis (NEC) remains uncertain. This study aims to provide an exploration of transfusion and NEC in very preterm infants. Using data from the Chinese Neonatal Network cohort study between 2019 and 2021, the analysis focused on very preterm infants (with a birth weight of < 1500 g or a gestational age of < 32 weeks) who developed NEC after receiving transfusions. The time interval between the prior transfusion and NEC was analyzed. An uneven distribution of the time interval implies an association of transfusion and NEC. Additionally, multivariable logistic analysis was conducted to detect the prognosis of defined transfusion-associated NEC(TANEC). Of the 16,494 infants received RBC transfusions, NEC was noted in 1281 (7.7%) cases, including 409 occurred after transfusion. Notably, 36.4% (149/409) of post-transfusion NEC occurred within 2 days after transfusion. The time interval distribution showed a non-normal pattern (Shapiro–Wilk test, W = 0.513, P < 0.001), indicating a possible link between transfusion and NEC. TANEC was defined as NEC occurred within 2 days after transfusion. Infants with TANEC had a higher incidence of death (adjusted OR 1.69; 95% CI 1.08 to 2.64), severe bronchopulmonary dysplasia (adjusted OR 2.03; 95% CI 1.41 to 2.91) and late-onset sepsis (adjusted OR 2.06; 95% CI 1.37 to 3.09) compared with infants without NEC after transfusion. Unevenly high number of NEC cases after RBC transfusions implies transfusion is associated with NEC. TANEC is associated with a poor prognosis. Further research is warranted to enhance our understanding of TANEC.
GnRH agonist early follicular challenge test as a predictor of ovarian response in antagonist cycles for fertility preservation
Authors: Yerushalmi Gil M. , Avraham Sarit , Kedem Alon , Youngster Michal , Barkat Jonathan , Baruchin Ohad , Gat Itai , Yaakov Odelia , Gidoni Yariv , Hourvitz Ariel 
Published: June 2024

AbstractThe aim of our study was to evaluate if the response to follicular GnRH agonist (GnRHa) trigger be used to predict intracycle ovarian response in GnRH antagonist cycles among women undergoing fertility preservation IVF. We conducted a prospective study of 146 GnRH antagonist oocyte pickup (OPU) cycles to evaluate GnRHa stimulation test (GAST). On day 2 of the cycle, basal E2 were measured, followed by injection of 0.2 mg GnRHa as part of the initial ovarian stimulation. 12 h later blood sampling was repeated (GAST E3). E2 response was used as test parameter. The major outcome was the number of mature cryopreserved oocytes. We found a linear correlation between both GAST E3 level and GAST E3/E2 ratio and number of M2 oocytes. ROC curve analysis of GAST E3, GAST E3/E2 ratio, AFC and day 3 FSH for > 15 M2 and < 5 M2 oocytes was calculated. For GAST E3 levels obtaining < 5 M2 oocytes, an AUC value of 0.79 was found. For GAST E3 levels obtaining > 15 M2 oocytes, AUC value of 0.8. Patients with GAST E3 ≤ 384 pmol/l has 58.6% risk to obtain < 5 oocytes. Patients younger than 35 with GAST E3 > 708 pmol/l have 66% chance for freezing > 15 oocytes. The response to single GnRHa administration during GnRH antagonist cycle can be used as biomarker of ovarian reserve. This simple, widely available marker, which reflect the estradiol response of small follicles, might predict the response of the specific cycle, and can potentially be used to adjust the treatment dose.Trial registration number: 0304-20-ASF.
Research on short-term photovoltaic power generation forecasting model based on multi-strategy improved squirrel search algorithm and support vector machine
Authors: Zhu Ruijin , Li Tingyu , Tang Bo 
Published: June 2024

AbstractSolar photovoltaic (PV) power generation is susceptible to environmental factors, and redundant features can disrupt prediction accuracy. To achieve rapid and accurate online prediction, we propose a method that combines Principal Component Analysis (PCA) with a multi-strategy improved Squirrel Search Algorithm (SSA) to optimize Support Vector Machine (MISSA-SVM) for prediction. Initially, to mitigate the impact of redundant features on prediction accuracy, KPCA is employed for feature dimensionality reduction. Subsequently, SVM is suggested as the foundational algorithm for constructing the prediction model. Furthermore, to address the influence of hyperparameter selection on model performance, SSA is introduced for optimizing SVM hyperparameters, with the aim of establishing the optimal prediction model. Moreover, to enhance solution efficiency and accuracy, a multi-strategy approach termed MISSA is proposed, which integrates Population Initialization based on the Tent map, Nonlinear Predator Presence Probability, Chaotic-based Dynamic Opposition-based Learning, and Selection Strategy, to refine SSA. Finally, through case studies, the performance of MISSA optimization is assessed using challenging CEC2021 test functions, demonstrating its high optimization performance, stability, and significance. Subsequently, the performance of the prediction model is validated using two datasets, showcasing that the proposed prediction method achieves high accuracy and robust prediction stability.