bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent advances in the management of primary hepatic tumors refinement of surgical techniques and effect on outcome
Authors: Sharma Rohit , Gibbs John F. 
Published: May 2010

AbstractAdvances in diagnostic, anesthetic, and surgical techniques have led to significant reductions in perioperative morbidity and mortality. The preoperative factors that have been of particular importance are a careful evaluation of hepatic function and of the predicted future liver remnant (FLR) volume prior to a decision on the feasibility of resection. Better patient selection, increased understanding of the liver anatomy leading to anatomical resections has together led to marked improvement in outcomes. In this article, we discuss the pre‐ and intraoperative factors, which have evolved in the last decade influencing the trend towards increased safety. We also share our technique of liver resection. J. Surg. Oncol. 2010; 101:745‐754. © 2010 Wiley‐Liss, Inc.
Part 2 – Coherent Light: “From Chips to Ships”
Authors: Poprawe Reinhart , Loosen Peter , Schulz Wolfgang , Brajdic Mihael , Gillner Arnold , Beckemper Stefan , Schleifenbaum Henrich , Bergmann Klaus , Gottmann Jens , Willenborg Edgar , Wortmann Dirk , Gasser Andres , Petring Dirk , Backes Gerhard , Noll Reinhard , Sturm Volker , Wehner Martin , Hinke Christian 
Published: May 2010

AbstractThis article is the second part of a two‐part series about the history as well as the future of laser technology. In the first part (published in Laser Technik Journal issue 2/2010), the history processes and their perspectives have been discussed as well as the effects on markets and megatrends, thus their societal impact have been displayed. In the following we will focus on the environmental “green” aspects of coherent light.
Vom Laser fasziniert
Authors: Treffert Claudia 
Published: May 2010

AbstractSeit fast 20 Jahren produziert der mittelständische Dienstleister Weihbrecht Lasertechnik Prototypen, Einzelteile, Vor­ und Kleinserien im Auftrag von Unternehmen zahlreicher Branchen. Die Auftraggeber: meist Entwickler und Konstrukteure. Das wichtigste Werkzeug von Anfang an: der Laser.
Ruck Zuck zum Bauteil
Authors: Bartels Florian 
Published: May 2010

AbstractModerne Strahlquellen haben die Grenzen der materialstärken‐ und leistungsabhängigen Schneidgeschwindigkeit deutlich angehoben. Speziell der Einsatz neuester Festkörperlaser (Scheibenlaser, Faserlaser) ermöglicht es, im Dünnblechbereich deutlich höhere Schneidgeschwindigkeiten bei gleicher Laserleistung im Vergleich zu Co2‐Strahlquellen zu erreichen. Die hauptsächlichen Gründe hierfür sind in der besseren Strahlqualität und in der höheren Absorption dieser Wellenlänge an der Schneidfront von Metallen zu suchen. Dieser Zugewinn kann entweder zur Laserleistungsreduzierung oder zur Produktivitätssteigerung der Maschine eingesetzt werden. Eine Produktivitätssteigerung ist jedoch nur möglich, wenn auch die Dynamikgrenzen der Führungsmaschinen angehoben werden. Die Herausforderung für Flachbettmaschinen ergibt sich aus der Forderung nach einem großen Arbeitsfeld bei gleichzeitig höchster Dynamik und Führungsgenauigkeit.
Neue Markierungstechnik für Flachglas
Authors: Losch Patrick 
Published: May 2010

AbstractOb Tintenstrahldrucker, Papieretiketten oder das Siebdruckmarkierverfahren durch die neuartige LTF‐C Markiertechnik ersetzt werden kann kommt auf die individuelle Applikation an. In diesem Bericht werden die Möglichkeiten dieser neuen Technologie beleuchtet und die Unterschiede bzw. Vorzüge aufgezeigt.
Duchenne muscular dystrophy: Drug development and regulatory considerations
Authors: McNeil D. Elizabeth , Davis Carole , Jillapalli Devanand , Targum Shari , Durmowicz Anthony , Coté Timothy R. 
Published: May 2010

AbstractDuchenne muscular dystrophy (DMD) is one of the most commonly recognized dystrophinopathies. There are no approved therapeutic options available for this disease but recent discoveries have led to hope that effective therapies might be forthcoming. With funding from patient advocacy groups, private investors, and governmental bodies such as the Food and Drug Administration Office of Orphan Product Development (FDA/OOPD), gene modification and other molecular therapies are being actively investigated. However, since DMD patients are few in number and disease manifestations vary considerably in early and late stages of disease, obtaining the data needed for full evaluation of putative therapies may prove challenging. Should ambulation remain the focus of Phase 2/3 studies or should consideration be given to the primary causes of late‐stage morbidity and mortality, e.g., cardiac and respiratory dysfunction related to reduced or absent dystrophin production? It seems reasonable to argue that clinical trials planned for DMD should consider the entire population. Muscle Nerve, 2010
Inefficient dystrophin expression after cord blood transplantation in Duchenne muscular dystrophy
Authors: Kang Peter B. , Lidov Hart G.W. , White Alexander J. , Mitchell Matthew , Balasubramanian Anuradha , Estrella Elicia , Bennett Richard R. , Darras Basil T. , Shapiro Frederic D. , Bambach Barbara J. , Kurtzberg Joanne , Gussoni Emanuela , Kunkel Louis M. 
Published: May 2010

AbstractWe report a boy who received two allogeneic stem cell transplantations from umbilical cord donors to treat chronic granulomatous disease (CGD). The CGD was cured after the second transplantation, but 2.5 years later he was diagnosed with Duchenne muscular dystrophy (DMD). Examinations of his DNA, muscle tissue, and myoblast cultures derived from muscle tissue were performed to determine whether any donor dystrophin was being expressed. The boy was found to have a large‐scale deletion on the X chromosome that spanned the loci for CYBB and DMD. The absence of dystrophin led to muscle histology characteristic of DMD. Analysis of myofibers demonstrated no definite donor cell engraftment. This case suggests that umbilical cord–derived hematopoietic stem cell transplantation will not be efficacious in the therapy of DMD without additional interventions that induce engraftment of donor cells in skeletal muscle. Muscle Nerve, 2010
Seasonal variations on energy yield of a‐Si, hybrid, and crystalline Si PV modules
Authors: Nikolaeva‐Dimitrova Miglena , Kenny Robert P. , Dunlop Ewan D. , Pravettoni Mauro 
Published: May 2010

AbstractThis paper presents a study of long‐term outdoor performance of a‐Si and hybrid modules mounted in the same location over several years. The modules were also characterized indoors using standard measurement methods employing pulsed solar simulators at the European Solar Test Installation (ESTI). The present study is intended to contribute to future standards on energy rating by presenting a common procedure for correcting the outdoor performance measurements to standard test conditions and comparing the resulting module performance at real and laboratory conditions. A seasonal variation in output, higher in the summer and lower in the winter, suggests that the module performance improves due to annealing when the module temperature is higher. The total output energy per month for these two technologies and a reference c‐Si technology is also presented. Copyright © 2010 John Wiley & Sons, Ltd.
Photosensitized alkoxyamines as bicomponent radical photoinitiators
Authors: Versace Davy‐Louis , Lalevée Jacques , Fouassier Jean‐Pierre , Gigmes Didier , Guillaneuf Yohann , Bertin Denis 
Published: May 2010

AbstractThe photopolymerization ability of photosensitized alkoxyamines has been investigated. These compounds behave as interesting two‐component photoinitiators. Laser flash photolysis, electron spin resonance, and density functional theory allow to support the interactions encountered between the photosensitizer (benzophenone and isopropylthioxanthone) and the alkoxyamines (CO bond breaking and hydrogen transfer) and the side reactions of the nitroxide radical with photosensitizer (electron transfer). © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2910–2915, 2010
Clinical factors are not the best predictors of quality of sexual life and sexual functioning in women with early stage breast cancer
Authors: Den Oudsten Brenda L. , Van Heck Guus L. , Van der Steeg Alida F. W. , Roukema Jan A. , De Vries Jolanda 
Published: May 2010

AbstractBackground: Few studies have prospectively assessed the impact of breast cancer (BC) on women's sexual lives. Therefore, this study examines the determinants of quality of sexual life (QOSL), sexual functioning (SF), and sexual enjoyment (SE) at 6 and 12 months after surgical treatment.Methods: All participants completed a measure of QOSL (The World Health Organization Quality of Life assessment instrument‐100 (WHOQOL‐100)‐facet Sexual Activity) before diagnosis (Time‐1), and 1 (Time‐2), 3 (Time‐3), 6 (Time‐4) and 12 months (Time‐5) after surgical treatment. At Time‐1, women also completed questionnaires on personality (The State Trait Anxiety Inventory‐trait, NEO‐FFI), body image and self‐esteem (WHOQOL‐100), depressive symptoms (Center for Epidemiological Studies‐Depression Scale), and fatigue (Fatigue Assessment Scale). Furthermore, SF and SE (The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Breast Cancer module) were measured from Time‐2 onwards.Results: At baseline, the analysis included 223 women with early stage BC. Clinical factors did not predict QOSL, SF or SE. In the final analyses, trait anxiety predicted QOSL and SF at Time‐4 (p's<0.01). At Time‐5, agreeableness predicted QOSL and SE (p's<0.05). Having a partner and age predicted SF, while SE was predicted by educational level (Time‐4). In addition, fatigue predicted SE at Time‐4 (p<0.05). In general, QOSL diminished across time, while SF improved. However, women with a mastectomy did not differ from women with breast conserving therapy.Conclusions: Mainly personality and psychological factors affect patients' sexuality after surgical treatment. Clinical factors did not predict QOSL, SF or SE. More knowledge in this field will help professionals to identify women who are at risk of experiencing sexual problems and consequently will contribute to provide adequate support. Copyright © 2009 John Wiley & Sons, Ltd.
On the beautiful diverse Danube? Danubian floodplain forest vegetation and flora under the influence of river eutrophication
Authors: Mölder Andreas , Schneider Erika 
Published: May 2010

AbstractThe aim of this study was to investigate and compare the flora and vegetation of three well‐preserved hardwood floodplain forest areas along the river Danube and to discuss whether possible differences between the floodplain forests can be linked to river eutrophication. Flora and vegetation data from three study areas located on the Upper, Middle and Lower Danube in Central and Eastern Europe were compared using univariate and multivariate statistical methods. Special attention was paid to floristic composition, plant functional types, and ecological indicator values. We found that the three studied hardwood floodplain forests appeared to be rather different regarding floristic composition and herb‐layer vegetation. Despite the high beta diversity, the distribution of the plant functional types indicated generally equal habitat conditions, which were quite stable. The diversity of herb‐layer vegetation decreased downstream, while the indicators of nutrient availability pointed to increasing nutrient supply. The factor light apparently played a minor role for herb‐layer diversity. There is a remarkable congruence between the results of our floodplain vegetation analysis and the longitudinal river eutrophication patterns as described in the literature. We conclude that the nutrient input into Danubian hardwood floodplain forests increased downstream, resulting in higher nutrient availability for plants. This promoted especially the growth of tall and competitive forbs, which outcompeted other plant species. Even if the importance of the various eutrophication patterns is difficult to quantify, our study provides evidence that anthropogenic eutrophication has a distinct effect on the flora and vegetation of Danubian hardwood floodplain forests. Copyright © 2010 John Wiley & Sons, Ltd.
Emergency bedside ultrasound diagnosis of sub-massive acute pulmonary embolism: a case of the McConnell sign
Authors: Liao Michael M. , Theoret Jonathan , Dannemiller Elisa M. , Erickson Catherine , Sanz Geoffrey E. , Kendall John L. 
Published: May 2010

Abstract

Introduction
This is a case of a healthy 61-year-old man with acute onset of dyspnea and atrial flutter where bedside emergency ultrasound was used to identify a classic echocardiographic finding called the “McConnell sign”. The clinical presentation and this echocardiographic finding led to the presumptive diagnosis of acute pulmonary embolism.

Materials and methods
This is a case report and brief review of the literature.

Conclusion
Bedside echocardiography has important diagnostic value in the evaluation of suspected acute pulmonary embolism. Findings, such as the McConnell sign are relatively quick and easy to identify at the bedside and could provide valuable information to rapidly guide management decisions when further research defines its role in emergent bedside ultrasound.
A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects
Authors: Heinz Serena A. , Henson Dru A. , Nieman David C. , Austin Melanie D. , Jin Fuxia 
Published: May 2010

Quercetin, a flavonoid found in fruits and vegetables, is a strong antioxidant with anti-inflammatory, antimicrobial and immune-modulating properties. The purpose of the present study was to investigate the effects of long-term quercetin supplementation on innate immune function and inflammation in human subjects. Female subjects (n120; aged 30–79 years) were recruited from the community and randomised to one of three groups, with supplements administered using double-blinded procedures: 500 mg quercetin/d (n38), 1000 mg quercetin/d (n40) or placebo (n42). Subjects ingested two soft chew supplements twice daily during the 12-week study period. Fasting blood samples were obtained pre- and post-study and were analysed for plasma quercetin, IL-6, TNF-α and leucocyte subset cell counts. Natural killer cell activity (NKCA) and lymphocyte subsets were assessed in a subset of seventy-four subjects. Granulocyte oxidative burst activity (GOBA) and phagocytosis were assessed in sixty-four subjects. Eighteen subjects had overlapping data. Quercetin supplementation at two doses compared with placebo increased plasma quercetin (interaction effect;P < 0·001) but had no significant influence on blood leucocyte subsets, plasma IL-6 or TNF-α concentration, NKCA, GOBA or phagocytosis. NKCA was inversely correlated with BMI (r− 0·25;P = 0·035) and body fat percentage (r− 0·38;P = 0·001), and positively correlated with self-reported physical fitness level (r0·24;P = 0·032). In summary, results from the present double-blinded, placebo-controlled, randomised trial indicated that quercetin supplementation at 500 and 1000 mg/d for 12 weeks significantly increased plasma quercetin levels but had no influence on measures of innate immune function or inflammation in community-dwelling adult females.
The red fox (Vulpes vulpes) and the arctic fox (Vulpes lagopus) are definitive hosts ofSarcocystis alcesandSarcocystis hjortifrom moose (Alces alces)
Authors: DAHLGREN STINA S. , GJERDE BJØRN 
Published: May 2010

SUMMARYThe aim of this study was to determine whether foxes might act as definitive hosts ofSarcocystis alcesin moose. In 2 experiments, 6 silver foxes (Vulpes vulpes) and 6 blue foxes (Vulpes lagopus) were fed muscle tissue from moose containing numerous sarcocysts ofS. alces, and euthanased 7–28 days post-infection (p.i.). Intestinal mucosal scrapings and faecal samples were screened microscopically forSarcocystisoocysts/sporocysts, which were identified to species by means of species-specific primers and sequence analysis targeting the ssu rRNA gene. All foxes in both experiments became infected withSarcocystis; the oocysts were fully sporulated by 14 days p.i., containing sporocysts measuring 14–15×10 μm. Molecular identification revealed that the oocysts/sporocysts belonged to 2 species,S. alcesandSarcocystis hjorti, although sarcocysts ofS. hjortiwere only identified in moose subsequent to the infection of foxes. In the first experiment, all 8 foxes also became infected with aHammondiasp. derived from moose, shedding unsporulated, subspherical oocysts, measuring 10–12 μm in diameter, from 6–7 days p.i. onwards. The study proved that canids (the red fox and arctic fox) are definitive hosts forS. alcesandS. hjorti, as had been inferred from the phylogenetic position of these species.
Actinobacillus pleuropneumoniaesurface polysaccharides: their role in diagnosis and immunogenicity
Authors: Dubreuil J. Daniel , Jacques Mario , Mittal Khyali R. , Gottschalk Marcelo 
Published: May 2010

AbstractActinobacillus pleuropneumoniaeis an important pig pathogen that is responsible for swine pleuropneumonia, a highly contagious respiratory infection. Knowledge of the importance, composition and structural determination of the major antigens involved in virulence provides crucial information that could lead to the development of a rationale for the production of specific serodiagnostic tools as well as vaccine development. Thus, efforts have been devoted to study mainlyA. pleuropneumoniaevirulence determinants with special emphasis on the Apx toxins (forA. pleuropneumoniaeRTX toxins). In comparison, little attention has been given to the surface polysaccharides, which include capsular polysaccharides (CPS) and cell-wall lipopolysaccharides (LPS). Here, we review current knowledge on CPS and LPS ofA. pleuropneumoniaeused as diagnostic tools to monitor the infection and as immunogens for inclusion in vaccine preparations for animal protection.
A parallel algorithm to compute chemical organizations in biological networks
Authors: Centler Florian , Kaleta Christoph , Speroni di Fenizio Pietro , Dittrich Peter 
Published: May 2010

Abstract
Summary: Analysing genome-scale in silico models with stoichiometry-based methods is computationally demanding. The current algorithms to compute chemical organizations in chemical reaction networks are limited to small-scale networks, prohibiting a thorough analysis of large models. Here, we introduce a parallelized version of the constructive algorithm to determine chemical organizations. The algorithm is implemented in the Standard C programming language and parallelized using the message passing interface (MPI) protocol. The resulting code can be executed on computer clusters making use of an arbitrary number of processors. The algorithm is parallelized in an embarrassing parallel manner, providing good scalability.
Availability: An implementation of the algorithm including source code can be obtained from http://www.minet.uni-jena.de/csb/prj/ot/tools
Contact: florian.centler@ufz.de
GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base
Authors: Khelashvili George , Dorff Kevin , Shan Jufang , Camacho-Artacho Marta , Skrabanek Lucy , Vroling Bas , Bouvier Michel , Devi Lakshmi A. , George Susan R. , Javitch Jonathan A. , Lohse Martin J. , Milligan Graeme , Neubig Richard R. , Palczewski Krzysztof , Parmentier Marc , Pin Jean-Philippe , Vriend Gerrit , Campagne Fabien , Filizola Marta 
Published: May 2010

Abstract
Summary: Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers.
Availability and Implementation: The GPCR-OKB web application is freely available at http://www.gpcr-okb.org
Contact: marta.filizola@mssm.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Annular lichenoid dermatosis of youth: Report of the first Japanese case and published work review
Authors: HUH WookKang , KANITAKIS Jean 
Published: May 2010

AbstractAnnular lichenoid dermatosis of youth is a recently described skin disease with particular clinicopathological features. It has been so far described in 35 patients, all of whom (but one) were white. We report here the first case of annular lichenoid dermatosis of youth in a Japanese patient, who is the youngest reported with this diagnosis, and briefly review the salient clinicopathological features of this condition. Our observation shows that annular lichenoid dermatosis of youth can also affect Japanese patients; therefore, Japanese dermatologists should be aware of this particular dermatosis.
Localized crossed hyperhidrosis and the coexistence of thyroid gland disease
Authors: SERDAR Zehra A. , ALTUNAY Ilknur K. , YASAR Sirin , KAYAOGLU Semra , GÜNES Pembegül 
Published: May 2010

AbstractHyperhidrosis is the most common type of sweat gland disorder. It may be localized or generalized. The localized type usually occurs in a symmetrical fashion over the palms, soles and armpits as a response to emotional stimuli. Another form of the localized type is idiopathic localized unilateral hyperhidrosis which is very rare and the etiopathogenesis remains unclear. Here, we report a female patient who had localized crossed hyperhidrotic areas on her body (on the left side of the scalp, face and the shoulder and on the right side of the trunk) and also had thyroid gland disease. We herein discuss this extremely rare presentation of the disease and its association with thyroid gland disease.
Systematic review: steroid withdrawal in anti‐TNF‐treated patients with inflammatory bowel disease
Authors: Bultman E. , Kuipers E. J. , Van Der Woude C. J. 
Published: May 2010

Aliment Pharmacol Ther 2010; 32: 313–323SummaryBackground  The increasing awareness of increased risk for opportunistic infections when combining several immunosuppressant drugs led to new treatment goals for inflammatory bowel disease including limited use of steroids.Aim  To conduct a systematic review to establish figures for steroid withdrawal in anti‐TNF treated inflammatory bowel disease‐patients.Methods  Medline was searched using the search‐terms Ulcerative Colitis (UC) [Mesh], Crohn Disease (CD) [Mesh], IBD [Mesh], crohn, colitis, IBD and steroid sparing, all combined with infliximab and adalimumab. We selected English‐language publications that addressed the effect of anti‐TNF on steroid withdrawal. Studies had to assess patients with luminal CD or UC. Numbers of patients who were able to withdraw steroids were calculated.Results  Six studies could be included; five reporting on infliximab and one on adalimumab. Studies were heterogeneously designed. Overall, in the adult population, up to 38% of the patients were able to withdraw corticosteroids during infliximab therapy. In the paediatric population, up to 75% of the patients were able to withdraw corticosteroids during infliximab therapy.Conclusions  Although a consensus on the definition of steroid‐sparing is lacking, approximately two‐thirds of the inflammatory bowel disease‐patients are unable to withdraw corticosteroid treatment during anti‐TNF therapy.