bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Trans-Crustal Evolution of Miocene Magmatism Parental to Epithermal Mineralization in the Sierra Madre del Sur, Southern Mexico
Authors: Cano Néstor , Martiny Barbara M , Camprubí Antoni , González-Partida Eduardo , Schaaf Peter , Ortega-Obregón Carlos , Solís-Pichardo Gabriela 
Published: May 2024

Abstract
Arc-related volcanism results from the interplay of magmatic processes occurring in trans-crustal systems that consolidate over time in a given location. Trans-crustal systems comprise extensive networks of magma reservoirs and conduits at different depths, wherein melts cyclically differentiate and segregate before reaching the surface. The study of these systems provides valuable insights into crustal-scale phenomena, such as the evolution of the continental crust and the formation of metallogenic regions. In this study, we address the trans-crustal magmatic evolution of lower Miocene magmatism parental to several intermediate-sulfidation epithermal deposits in the eastern Sierra Madre del Sur igneous province, southern Mexico. Using a multi-methodological approach, we document changes over ca. 1.1 Myr in the magmatic system that fed andesitic-to-felsic volcanism in this region. We employ whole-rock REE ratios and λ parameters—which are used to quantify the shape of a REE pattern—to track the involvement of pressure-sensitive minerals in the deep-crustal magmatic evolution. The andesitic rocks consist of lava flows, porphyries, and dikes that collectively show REE patterns suggestive of control by fractionated or residual (i.e. in crustal melting) amphibole and/or clinopyroxene. In contrast, the felsic rocks consist of rhyolitic–dacitic ignimbrites, domes, and dikes that show contrasting REE patterns suggestive of control by plagioclase, clinopyroxene, amphibole, and/or garnet. The distinct pressure-sensitive mineral assemblages in the andesitic and felsic rocks indicate that the locus of deep-crustal magma evolution varied within the middle–lower crust. These magmas were episodically injected into ephemeral shallow crustal reservoirs (shortly?) before being erupted, inducing a progressive thermomechanical maturation of the middle–upper crust. Meanwhile, low degrees of crustal assimilation occurred as recorded by Mesozoic inherited zircon ages and Sr–Nd–Pb radiogenic isotopes. An extensive middle–lower crustal magma evolution has been linked to the formation of porphyry Cu deposits (i.e. ‘fertile’ magmatism). Given that intermediate-sulfidation epithermal deposits may be genetically linked with porphyry Cu deposits, the documented processes could have contributed to the formation of epithermal deposits in the region. However, magmatic fertility proxies resemble those from infertile magmas worldwide. Since these proxies have been exclusively applied to porphyry-type deposits, our results highlight the importance of developing new geochemical exploration tools applicable to a wider range of ore deposits.
Treatment of metastatic hormone-sensitive prostate cancer: from doublet therapy to triplet therapy
Authors: Ye Shi-jie , Huang Rui-da , Fei Xin , Tao Zhu-lei , Liu Wei-hua , Ma Qi 
Published: May 2024

Abstract
For metastatic prostate cancer, androgen deprivation therapy (ADT) is the key strategy to control the disease. However, after 18–24 months of treatment, most patients will progress from metastatic hormone-sensitive prostate cancer (mHSPC) to metastatic castration-resistant prostate cancer (mCRPC) even with ADT. Once patients enter into mCRPC, they face with significant declines in quality of life and a dramatically reduced survival period. Thus, doublet therapy, which combines ADT with new hormone therapy (NHT) or ADT with docetaxel chemotherapy, substitutes ADT alone and has become the “gold standard” for the treatment of mHSPC. In recent years, triplet therapy, which combines ADT with NHT and docetaxel chemotherapy, has also achieved impressive effects in mHSPC. This article provides a comprehensive review of the recent applications of the triplet therapy in the field of mHSPC.
The Balancing Act of Family and College: Reciprocity and Its Consequences for Black Students
Authors: Wiggins Yolanda 
Published: May 2024

Abstract
Literature indicates the ways that young adults –especially those from advantaged backgrounds—rely on parents during college and the transition to adulthood. Little research focuses on how the Black family reaches into college and Black college students’ provision of support to parents and other kin. The nexus of family and higher education is a rich site for investigating inequalities in educational attainment and outcomes. Based on interviews with Black undergraduates, this paper analyzes variation in familial involvement during college. It shows the ways in which Black students maintain a balancing act to meet academic responsibilities and family obligations. These practices help sustain the families they value but also reproduce class inequalities. The social organization of colleges and families imposes greater costs on disadvantaged students and offers greater benefits for advantaged students. The structure of education and constructions of family diminish obligations to family, narrow family ties, and mystify aspects of dependence, especially for disadvantaged students. Student narratives highlight the broad character of family values that often compete with academic obligations and detract from college immersion. Different forms and patterns of assistance and connection by class and gender are tied to structural resources and cultural differences, such as the place of family, the meaning of self, assessments of who counts as family, and reliance on a norm of one-way giving.
Shuffle Out, Shuffle In: Child Protective Services Contact and Institutional Shuffling among Middle-Class Black Mothers
Authors: Smith DeAnna Y 
Published: May 2024

Abstract
Researchers have shown how punitive state contact shapes the lives of poor Black individuals but have paid less attention to the role of punitive state contact in the lives of the Black middle-class. Drawing on in-depth interviews with 29 middle-class Black mothers recently investigated by Child Protective Services (CPS)—a punitive state institution with the ability to remove children from their homes—this article asks how Black mothers who are not poor assess risk of future CPS contact and navigate the threats it poses. Armed with greater resources than poor mothers, middle-class Black mothers work to evade future CPS contact through institutional shuffling—a resource-intensive evasion strategy that involves shuffling children out of certain types of institutions and into others. I find that middle-class Black mothers shuffle their children out of formal institutions and into informal ones, out of predominantly white institutions and into predominantly Black ones, and out of institutions where they have weak ties and into institutions where they have strong ties. While shuffling may shield mothers and children from future CPS contact, it may also shrink mothers’ networks, isolate children from a broad array of institutional resources, and inadvertently expose middle-class Black families to greater surveillance and punishment.
Choosing Health: acceptability and feasibility of a theory-based, online-delivered, tailored weight loss, and weight loss maintenance intervention
Authors: Palacz-Poborczyk Iga , Naughton Felix , Luszczynska Aleksandra , Januszewicz Anna , Quested Eleanor , Hagger Martin S , Pagoto Sherry , Verboon Peter , Robinson Suzanne , Kwasnicka Dominika 
Published: May 2024

Abstract
Few weight loss and weight loss maintenance interventions are tailored to include factors demonstrated to predict the user’s behavior. Establishing the feasibility and acceptability of such interventions is crucial. The aim of this study was to assess the acceptability and feasibility of a theory-based, tailored, online-delivered weight loss and weight loss maintenance intervention (Choosing Health). We conducted a mixed methods process evaluation of the Choosing Health tailored intervention, nested in a randomized controlled trial (N = 288) with an embedded N-of-1 study, investigating participants’ and implementers’ experiences related to intervention context, implementation, and mechanisms of impact. Measures included: (i) surveys, (ii) data-prompted interviews (DPIs) with study participants, (iii) semi-structured interviews with implementers, and (iv) intervention access and engagement data. Five themes described the acceptability of the intervention to participants: (i) monitoring behavior change and personal progress to better understand the weight management process, (ii) working collaboratively with the intervention implementers to achieve participants’ goals, (iii) perceived benefits of non-judgmental and problem-solving tone of the intervention, (iv) changes in personal perception of the weight management process due to intervention tailoring, and (v) insufficient intervention content tailoring. The intervention delivery was feasible, however, emails and text messages differed in terms of accessibility and resources required to deliver the content. The use of Ecological Momentary Assessment as a technique to gather personal data for further tailoring was acceptable, and facilitated behavior change monitoring. Personalization of the intervention content above and beyond domain-specific issues, for example, by addressing participants’ social roles may better match their needs. Support from the implementers and feedback on body composition changes may increase participants’ engagement.
The use of PD-1 functional knockout rats to study idiosyncratic adverse reactions to nevirapine
Authors: Cho Tiffany , Hayes Anthony , Henderson Jeffrey T , Uetrecht Jack 
Published: May 2024

Abstract
Idiosyncratic drug reactions (IDRs) are associated with significant patient morbidity/mortality and lead to considerable drug candidate attrition in drug development. Their idiosyncratic nature makes the study of IDRs difficult. In particular, nevirapine is associated with a relatively high risk of serious skin rash and liver injury. We previously found that nevirapine causes a similar skin rash in female Brown Norway rats, but these animals do not develop significant liver injury. Programmed cell death protein-1 (PD-1) is an immune checkpoint involved in immune tolerance, and anti-PD-1 antibodies have been used to treat cancer. However, they increase the risk of liver injury caused by co-administered drugs. We found that PD-1−/− mice are more susceptible to drug-induced liver injury, but PD-1−/− mice are not a good model for all drugs. In particular, they do not develop a skin rash when treated with nevirapine, at least in part because they lack the sulfotransferase in their skin that forms the reactive metabolite responsible for the rash. Therefore, we developed a PD-1 mutant (PD-1m/m) rat, with an excision in the ligand-binding domain of PD-1, to test whether nevirapine would cause a more serious skin rash in these animals. The PD-1m/m rat was based on a Sprague Dawley background, which has a lower incidence of skin rash than Brown Norway rats. The treated PD-1m/m rats developed more severe liver injury than PD-1−/− mice, but in contrast to expectations, they did not develop a skin rash. Functional knockouts provide a unique tool to study the mechanisms of IDRs.
Decontamination of Actinide-contaminated Injured Skin with Ca-DTPA Products Using an Ex Vivo Rat Skin Model
Authors: Van der Meeren Anne , Devilliers Karine , Griffiths Nina , Chaplault Anne-Sophie , Defrance Martine , Ducouret Gaëtan , Pasteur Michaël , Laroche Pierre , Caire-Maurisier François 
Published: May 2024

Abstract
Skin contamination by α-emitting actinides such as plutonium and americium is a risk for workers during nuclear fuel production and reactor decommissioning. Decontamination of skin is an important medical countermeasure to limit potential internal contamination, particularly in the case of injured skin. Current recommendations include undressing of the victim followed by skin washing using soap or chelating agents, such as diethylene triamine pentaacetic acid (DTPA). The goal of the present work is to assess the efficacy of a novel Ca-DTPA loaded gel to decontaminate injured skin exposed to plutonium or americium as compared to recommended treatments. For decontaminant testing on injured skin, whole body skin was obtained from euthanized rats and lesions created using a metallic brush. Delimited test areas were contaminated with plutonium or americium solutions of known properties. Various protocols were tested including time before contamination, duration of gel application, washing steps, as well as the concomitant addition or not of dressings. Activity was measured in each decontamination product and in skin. Data indicate that healthy skin was easier to decontaminate than damaged skin. On injured skin, we demonstrated an increased decontamination efficacy of the Ca-DTPA gel formulation as compared to the solution. Importantly, gel application alone was effective, and further gel applications could be used for residual activity.
Body mass weighted prostate-specific antigen levels, new markers to predict locally advanced prostate cancer after prostatectomy
Authors: Ou Ying-Lun , Yang Ming-Hsin , Kao Chien-Chang , Meng En , Chen Jin-Li , Tsao Chih-Wei , Sun Guang-Huan , Yu Dah-Shyong , Cha Tai-Lung , Wu Sheng-Tang 
Published: May 2024

Background:
Prostate-specific antigen (PSA) remains the most useful marker for screening, risk categorization, and follow-up in patients with prostate cancer. In the obese population, several studies have revealed that obesity may not only inversely interfere with the concentration of PSA, but also increase the risk of prostate cancer. Thus, we considered using the body mass weighted PSA levels, presented as serum PSA concentration multiplied by body weight or body mass index (BMI), instead of traditional PSA concentration, as potential markers to predict locally advanced prostate cancer after prostatectomy.

Methods:
We retrospectively collected and analyzed data acquired from a single institute at which robot-assisted laparoscopic radical prostatectomy was performed. A total of 174 patients underwent radical prostatectomy, and the collected data included age, PSA level, body weight, BMI, and pathology results.

Results:
A total of 174 patients were diagnosed with adenocarcinoma of the prostate by needle biopsy, and most (N = 165) were considered to have localized disease on preoperative multiparameter magnetic resonance imaging. After prostatectomy, 73% (N = 127) of the patients remained in the localized disease group (group A) and 27% (N = 47) of the patients were reclassified to the locally advanced prostate cancer (group B). The value of PSA was higher in group B (16.9 vs 11.2 ng/dL; p = 0.062), but there was no statistically significant difference between the two groups. After using the numerical values of PSA × body weight and PSA × BMI, a statistically significant difference emerged between the two groups (p = 0.0198 in PSA × BW; p = 0.0110 in PSA × BMI).

Conclusion:
The body mass-weighted PSA levels, instead of the traditional PSA concentration, may be better markers for predicting non-organ-confined disease after surgery. It may also be useful in screening and risk categorization.
Association between daily sitting time and kidney stones based on the National Health and Nutrition Examination Survey (NHANES) 2007–2016: a cross-sectional study
Authors: Li Ya , Di Xingpeng , Liu Mengzhu , Wei Jingwen , Li Tianyue , Liao Banghua 
Published: May 2024

Background:
Kidney stones are among the most common urological conditions affecting ~9% of the world population. Although some unhealthy diets and unhealthy lifestyles are reportedly risk factors for kidney stone, the association between daily sitting time and kidney stone has not been explored.

Materials and Methods:
This large-scale, cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) database 2007–2016. Kidney stone history and daily sitting time were retrieved from the questionnaire and 24 hour (h) recall interviews. Logistic regression and subgroup analysis were conducted to investigate the association. The analysis was further stratified by vigorous recreational activity.

Results:
A total of 19 188 participants aged ≥20 years with complete information were included in this study. The overall prevalence of kidney stone was 9.6%. Among participants without vigorous recreational activity, a trend towards an increasing prevalence of kidney stone was observed with increased daily sitting time. However, the trend was not observed in individuals who participated in vigorous recreational activity, as they experienced a decreased risk of kidney stone despite having a daily sitting time of 6–8 h (crude model OR=0.659, 95% CI: 0.457–0.950, P=0.028), indicating that vigorous recreational activity may partially attenuate the detrimental effect of prolonged sitting time.

Conclusion:
Our study revealed an increasing trend of prevalence of kidney stone with increased daily sitting time among the population not performing vigorous recreational activity despite the difference was nonsignificant. Vigorous recreational activity may modify the association between daily sitting time and kidney stone. More prospective cohort studies are warranted to further examine this association.
Dexmedetomidine use during orthotopic liver transplantation surgery on early allograft dysfunction: a randomized controlled trial
Authors: Yang Liqun , Zhu Ling , Qi Bo , Zhang Yin , Ni Chenlu , Zhang Yijue , Shi Xiao , Xia Qiang , Masters Joe , Ma Daqing , Yu Weifeng 
Published: May 2024

Background:
Previous studies have shown a protective effect of dexmedetomidine use in kidney transplantation. In contrast, it is not known whether intraoperative administration of dexmedetomidine can reduce early allograft dysfunction (EAD) incidence following liver transplantation.

Objective:
To investigate the effect of dexmedetomidine use during surgery on EAD following orthotopic liver transplantation (OLT).

Study Design:
This is a single-center, double-blinded, placebo-controlled randomized clinical trial. Three hundred thirty adult patients undergoing OLT were enrolled from 14th January 2019 to 22nd May 2022. Patients received dexmedetomidine or normal saline during surgery. One year follow-ups were recorded.

Methods:
Patients were randomized to two groups receiving either dexmedetomidine or normal saline intraoperatively. For patients in the dexmedetomidine group, a loading dose (1 μg/kg over 10 min) of dexmedetomidine was given after induction of anesthesia followed by a continuous infusion (0.5 μg/kg /h) until the end of surgery. For patients in the normal saline group, an equal volume loading dose of 0.9% saline was given after the induction of anesthesia followed by an equal volume continuous infusion until the end of surgery. The primary outcome was EAD. Secondary outcomes included primary graft nonfunction, acute kidney injury, and acute lung injury/acute respiratory distress syndrome.

Results:
Of 330 patients included in the intention-to-treat analysis, 165 were in the dexmedetomidine group [mean (SD) age, 49 (10) years; 117 (70.9%) men], and 165 were in the normal saline group [mean SD age, 49 (9) years; 118 (74%) men]. 39 (24.4%) patients in the dexmedetomidine group and 31 (19.4%) in normal saline group developed EAD and the difference was statistically insignificant (P=0.28). Secondary outcomes including primary graft nonfunction and acute kidney injury was similar between the two groups.

Conclusion:
Intraoperative administration of dexmedetomidine did not reduce EAD rate after OLT.
Ethical Decision-Making Confidence and Professional Values Among Nurse Leaders
Authors: Gassas Roai , Ahmed Mohamed Eldigire , Asloob Mashael 
Published: May 2024

OBJECTIVES
The aims of this study were to describe differences in nurse leaders' ethical decision-making confidence and their professional values based on identified characteristics and to explore the relationship between ethical decision making and professional values.

BACKGROUND
Nurse leaders have multiple duties and obligations toward their patients, other staff, and the organizations where they work. However, ethical decisions can be complex, requiring the guidance of professional values and critical appraisal of the situation.

METHODS
This study was conducted using a correlational design. Convenience sampling was used, resulting in a sample of 56 nurse leaders in various positions.

RESULT
Ethical decision making and professional values were found to be strongly correlated.

CONCLUSION
Ethical decision making and professional values are highly correlated in this sample. Understanding the importance of the effects of certain factors on ethical decision making can assist in forming an environment supportive of ethical practices for nurses.
18F-FDG PET/CT in Cystic Papillary Thyroid Carcinoma
Authors: Foppiani Luca , Morbini Patrizia , Catrambone Ugo , Fiz Francesco , Piccardo Arnoldo 
Published: May 2024

Abstract
A 52-year-old woman was evaluated for the appearance of a neck lump and dysphonia. Neck ultrasonography showed a large cystic nodule in the right thyroid lobe, confirmed by fine-needle aspiration cytology. Thyroid function and calcitonin were normal. 18F-FDG PET/TC showed moderate tracer uptake by the outer ring of the large hypodense formation. Right hemithyroidectomy was performed; since intraoperative histology showed an intracystic and invasive papillary thyroid carcinoma, a completion thyroidectomy was done. Definitive histopathology confirmed the intraoperative findings. 18F-FDG PET/CT may be a useful imaging procedure in evaluating patients with cystic thyroid nodules whenever clinical/ultrasonographic features are suspicious for malignancy.
Making Choices
Authors: Antunez Alexis G. , Sinco Brandy R. , Saucke Megan C. , Bushaw Kyle J. , Jensen Catherine B. , Dream Sophie , Fingeret Abbey L , Livhits Masha J , Mathur Aarti , McDow Alexandria , Roman Sanziana A. , Voils Corrine I. , Sydnor Justin , Pitt Susan C. ,   on behalf of the CHOiCE Collaborative (Comparing Health Outcomes in Cancer Experience)
Published: May 2024

Objective:
To evaluate the relative importance of treatment outcomes to patients with low-risk thyroid cancer (TC).

Summary Background Data:
Overuse of total thyroidectomy (TT) for low-risk TC is common. Emotions from a cancer diagnosis may lead patients to choose TT resulting in outcomes that do not align with their preferences.

Methods:
Adults with clinically low-risk TC enrolled in a prospective, multi-institutional, longitudinal cohort study from 11/2019-6/2021. Participants rated treatment outcomes at the time of their surgical decision and again 9 months later by allocating 100 points amongst 10 outcomes. T-tests and Hotelling’s T2 statistic compared outcome valuation within and between subjects based on chosen extent of surgery (TT vs. lobectomy).

Results:
Of 177 eligible patients, 125 participated (70.6% response) and 114 completed the 9-month follow-up (91.2% retention). At the time of the treatment decision, patients choosing TT valued the risk of recurrence more than those choosing lobectomy and the need to take thyroid hormone less (P<0.05). At repeat valuation, all patients assigned fewer points to cancer being removed and the impact of treatment on their voice, and more points to energy levels (P<0.05). The importance of the risk of recurrence increased for those who chose lobectomy and decreased for those choosing TT (P<0.05).

Conclusion:
The relative importance of treatment outcomes changes for patients with low-risk TC once the outcome has been experienced to favor quality of life over emotion-related outcomes. Surgeons can use this information to discuss the potential for asthenia or changes in energy levels associated with total thyroidectomy.