bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual-color FISH analyses of xenogeneic human fibroblast sheets transplanted to repair lung pleural defects in an immunocompromised rat model
Authors: Kanzaki Masato , Takagi Ryo , Mitsuboshi Shota , Shidei Hiroaki , Isaka Tamami , Yamato Masayuki 
Published: May 2024

Abstract
Background
Pulmonary air leaks (PALs) due to visceral pleura injury during surgery is frequently observed after pulmonary resections and the complication is difficult to avoid in thoracic surgery. The development of postoperative PALs is the most common cause of prolonged hospitalization. Previously, we reported that PALs sealants using autologous dermal fibroblast sheets (DFSs) harvested from temperature-responsive culture dishes successfully closed intraoperative PALs during lung resection.

Objective
In this study, we investigated the fate of human DFSs xenogenetically transplanted onto lung surfaces to seal PALs of immunocompromised rat. Dual-color FISH analyses of human fibroblast was employed to detect transplantation human cells on the lung surface.

Results
One month after transplantation, FISH analyses revealed that transplanted human fibroblasts still composed a sheet-structure, and histology also showed that beneath the sheet’s angiogenesis migrating into the sheets was observed from the recipient tissues. FISH analyses revealed that even at 3 months after transplantation, the transplanted human fibroblasts still remained in the sheet. Dual-color FISH analyses of the transplanted human fibroblasts were sparsely present as a result of the cells reaching the end of their lifespan, the cells producing extracellular matrix, and remained inside the cell sheet and did not invade the lungs of the host.

Conclusions
DFS-transplanted human fibroblasts showed that they are retained within cell sheets and do not invade the lungs of the host.
New error bounds for Newton’s formula associated with tempered fractional integrals
Authors: Hezenci Fatih , Budak Hüseyin 
Published: May 2024

AbstractIn this paper, we first construct an integral identity associated with tempered fractional operators. By using this identity, we have found the error bounds for Simpson’s second formula, namely Newton–Cotes quadrature formula for differentiable convex functions in the framework of tempered fractional integrals and classical calculus. Furthermore, it is also shown that the newly established inequalities are the extension of comparable inequalities inside the literature.
Factors and management techniques in odontogenic keratocysts: a systematic review
Authors: Dioguardi Mario , Quarta Cristian , Sovereto Diego , Caloro Giorgia Apollonia , Ballini Andrea , Aiuto Riccardo , Martella Angelo , Lo Muzio Lorenzo , Di Cosola Michele 
Published: May 2024

Abstract
Objectives
Odontogenic keratocysts exhibit frequent recurrence, distinctive histopathological traits, a tendency towards aggressive clinical behavior, and a potential linkage to the nevoid basal cell carcinoma syndrome. The aim of this systematic review is to compile insights concerning the control of this condition and assess the effectiveness of various treatment approaches in reducing the likelihood of recurrence.

Materials and methods
The following systematic review adhered to the PRISMA guidelines. The systematic revision was registered on PROSPERO and structured around the questions related to the population, intervention, control, outcome and study design (PICOS).

Results
After conducting a search on the PubMed database, we initially identified 944 records. After using end-note software to remove duplicate entries, results totally with 462 distinct records. A thorough review of the titles and abstracts of these articles led to the selection of 50 papers for in-depth examination. Ultimately, following the application of our eligibility criteria, we incorporated 11 articles into our primary outcome analysis.

Conclusion
Among the studies examined, the most common location for these lesions was found to be in the area of the mandibular ramus and the posterior region of the mandible. In cases where the exact location wasn’t specified, the mandible emerged as the predominant site. When we considered the characteristics of these lesions in studies that mentioned locularity, most were described as unilocular in two studies, while in two other studies, the prevalence of multilocular lesions was observed. Risk factors associated with keratocyst recurrence include younger patient age, the presence of multilocular lesions, larger lesion size, and a longer anteroposterior dimension. Certain treatment methods have demonstrated a lack of relapses. These include the use of 5-fluorouracil, marsupialization, enucleation with peripheral ostectomy or resection, enucleation and curettage, as well as resection without creating continuity defects. However, it is important to note that further research is essential. Prospective studies and randomized trials are needed to collect more comprehensive evidence regarding the effectiveness of various treatment approaches and follow-up protocols for managing odontogenic keratocysts.

Clinical relevance
Odontogenic keratocysts still enter into differential diagnoses with other lesions that affect the jaw bones such as ameloblastama and other tumor forms, furthermore it is not free from recurrence, therefore the therapeutic approach to the lesion aimed at its elimination can influence both the possible recurrence and complications, knowledge of the surgical methods that offer the most predictable and clinically relevant result for the management of follow-up and recurrences.
An alternative approach to ontology-based curriculum development in higher education
Authors: Piriyapongpipat Pattamaporn , Goldin Sally , Ditcharoen Nadh 
Published: May 2024

AbstractGlobal trends in higher education emphasize the development of curricula that offer greater responsiveness to learners. Creating flexible and responsive curricula will require additional support systems for curriculum management. The first step toward sustainably developing this kind of system is to represent essential curricular information in a way that allows sharing common components across various work processes within the educational environment. The current research implements a new approach for representing curriculum components, by systematically analyzing external source data to extract the basic knowledge, skills and dependencies which then become objects into an ontology. The resulting ontology should act as a computationally-accessible model of the curriculum with sufficient information and usable quality. This paper describes a trial implementation of our approach using actual curriculum documents. Results from performance metrics and expert evaluation validate the proposed strategy and suggest that the approach is feasible for real-world practice.
Integrating incentive spirometry and progressive muscle training in managing respiratory compromise in Guillain–Barré syndrome
Authors: Bappah Babangida Shehu , Womboh Idoo , Ewah Patrick Ayi , Umar Lawan , Mohammed Jibril 
Published: May 2024

Abstract
Background
Guillain–Barré syndrome (GBS) is one of the most common causes of acute neuromuscular paralysis in developed and developing countries. It is a complex autoimmune disorder characterized by progressive skeletal muscle weakness, potentially involving respiratory muscles. The purpose of this case report was to explore the importance of combined use of incentive spirometry and progressive muscle training as essential therapies in a 20-year-old male diagnosed with GBS.

Case presentation
This is a case report of a 20-year-old Nigerian male university student who was brought to the trauma center on a wheelchair with weakness of both upper and lower limbs which was said to be progressive, and a diagnosis of GBS was made by the attending physician. On examination, he was discovered to have quadriparesis with mild respiratory muscle involvement. He deteriorated with cardiopulmonary compromise and was transferred into intensive care unit. He was managed with supplementary oxygen therapy until there was significant improvement and he was weaned off oxygen therapy and then needed further evaluation and management. The patient was placed on immunoglobulin in conjunction with incentive spirometry, progressive strengthening exercise and exercise training which proved to be effective as he regained all the lost function within a few weeks of symptoms.

Results
This intervention delves into the synergistic potential of fortifying respiratory muscles and improving respiratory function alongside overall muscle strength which resulted in the patient regaining all the lost function within a few weeks.

Conclusions
The combined use of incentive spirometry and progressive muscle training in addition to immunoglobulin was effective in modulating GBS related impairments. We recommend the use of a multifaceted strategy in the management of patients with GBS and other similar health conditions.
Robot-assisted treatment of secondary epilepsy caused by parasitic infection: a case report
Authors: Luo Juan , Chen Xin , Yu Sixun , Shu Haifeng 
Published: May 2024

Abstract
Background
Cerebral sparganosis represents the most severe manifestation of sparganosis, with a relatively low global incidence. For cases of secondary epileptic seizures caused by sparganosis infection in the functional areas of the brain, what advanced neurosurgical techniques should be employed to precisely identify and excise the epileptic lesions in the deep functional areas of the brain, aiming to achieve maximal removal while minimising the risk of neurological deficits? This remains a current challenge for epilepsy surgeons.

Case presentation
A 24-year-old Chinese male was admitted to our hospital, presenting with a history of left limb twitching persisting for over a year. His main clinical symptoms presented twitching and numbness of his left limb without loss of consciousness. Under the premise of inappropriate anti-seizure treatment, recurrent epilepsy attacked persist. The patient's diagnosis was considered as “space-occupying lesions in the several lobes of brain, secondary epilepsy” after comprehensive assessment and discussion. And experts considered that the patient's space-occupying lesions in the right frontal and parietal lobes were highly suspected to be infected by parasites. This report delved into the application of neurosurgery robot-assisted frameless stereotaxic technology and intraoperative stereotactic electroencephalography (SEEG) monitoring technology to accurately locate and optimize removal of parasite-related epileptic lesions situated in functional areas of the brain. As a result, the patient had achieved seizure freedom, leaving no symptoms of neurological deficit.

Conclusions
With the highly integrated development of imaging technology, mechanical technology, computer control technology, and artificial intelligence, surgical robots are poised to play a larger role across various neurosurgical specialties in the future. Considering benefits for patients and the promising application of this technology, its utilization holds significant value.
Study on the distribution of average wind speeds at a mountainous bridge site for structural durability design
Authors: Cheng Cheng , Luo Beilong , Jiang Yan , Liu Jian 
Published: May 2024

AbstractConventional wind speed distribution methods (e.g., Rayleigh distribution and Weibull distribution) may not adequately capture complex characteristics of wind fields in mountainous areas. To address this problem, this study proposes a semi-parametric mix method for modeling the distribution of average wind speeds based on the combination of nonparametric Kernel Density Estimation (KDE) and Generalized Pareto Distribution (GPD). In the proposed method, KDE focuses on capturing the distribution in the main part of average wind speeds, while GPD aims at performing the distribution in terms of those in the extreme part. The segment point (i.e., the threshold) between KDE and GPD distributions is determined based on the combination of conditional mean excesses criterion and empirical rule. Meanwhile, the selection of modeling parameters should ensure that the mix distribution model is continuous and differentiable at the identified threshold point. Then, the commonly-used conditional probability model is further introduced to describe the wind direction distribution. Finally, a case study based on the measured 10-min average wind speeds at a mountainous bridge site is employed to demonstrate the effectiveness of the proposed method. The results indicate that: (1) the distribution of omnidirectional average wind speeds in the mountainous bridge site exhibits an obviously single-peak characteristic, while those considering wind directionality present a certain bimodal characteristic; (2) the proposed method can effectively describe wind speed distributions with different statistical characteristics, and the fitting accuracy outperforms the frequently-employed Weibull distribution model.
Experimental characteristic evaluation of micro hole EDM drilling of Ni51.58Ti48.34 alloy with copper electrode and response optimization using GRG assisted with GA
Authors: Sahoo Amiya Kumar , Mishra Dhananjay R. 
Published: May 2024

AbstractNitinol, a biocompatible material, is gradually becoming famous for its superelasticity, shape memory and corrosion resistance behaviours. However, the lower machinability due to the strain-hardening effect and lower thermal conductivity is contrary to its adventitious properties. Therefore, EDM is a preferable machining process for materials like Nitinol. EDM, thermal processing, raises the concern of processing Nitinol with minimal variation of its well-known properties and economical machining process. Therefore, this article deals with multi-objective optimization through GRG-assisted GA of µ-EDM drilling of Ni51.58Ti48.34 alloy using a copper electrode and distilled water. It was found that discharge current and servo voltage significantly influence the responses. The GA, with the assistance of GRG, optimized the multiple responses (viz. MRR, TWR and DoT) and yielded a discharge current of 12 A, gap voltage of 40 V, discharge time of 2 µs, charging time of 9 µs and flushing pressure of 50 kg/cm2. The confirmatory experiment yielded MRR of 0.0036 g/min, TWR of 0.0038 g/min and DoT of 0.0089 radians. There were variations of the predicted and experimentally validated responses by − 2.78, 26.32 and 35.96% for MRR, TWR and DoT, respectively.
Predictors for interest to participate in digital mental health therapy: a cross-sectional survey of individuals with anxiety and depression
Authors: Gunawardena Tharidu , Bartholmae Marilyn M. , Karpov Matvey V. , Dod Rohan , Ahuja Kripa , Rajendran Aishwarya , Kathrotia Mayuri , Dodani Sunita 
Published: May 2024

Abstract
Background
Due to a multitude of factors, the onset of the COVID-19 pandemic resulted in a significant increase in mental health issues within society, including depression and anxiety. Due to the increased trend of mental health disorders in society, digital mental health therapies are more useful than ever. With the emergence of programs utilizing Internet Cognitive Behavioral Therapy (iCBT), mental health resources are easily accessible and can be widely implemented to those in need.
The aim of this study was to identify predictors for interest to participate in SilverCloud digital mental health therapy among individuals with mild to severe anxiety and/or depression based on preliminary findings from the COVIDsmart study.

Methods
COVIDSmart participants who had moderate to severe anxiety and/or depression based on the PHQ-9 and GAD-7 scores, and who consented to be contacted for future studies, were invited to complete a needs assessment survey via Research Electronic Data Capture (REDCap). This assessment used self-reported measures including medical diagnoses, mental health services received, reasons for anxiety and/or depression, the use of coping strategies, suicidal ideology using the Ask Suicide Questions tool, and whether they would be interested in receiving free digital mental therapy. Descriptive statistics were used to report participants’ demographics and a logistic regression was used to find predictors for interest in participation in SilverCloud. SAS 9.4 was used and p values < 0.05 were considered significant.

Results
Out of the original 782 COVIDsmart participants, 634 consented to be contacted for future studies, 280 were subsequently invited to complete the SilverCloud needs assessment, and 120 individuals completed it. The largest demographic among these participants were females (70.83%) who identified as White (80.83%). The mean age was 48.74 years (SD = 14.66). Results revealed that having a mental health comorbidity significantly predicted the likelihood of interest in participating in the SilverCloud digital mental health program (p = 0.027).

Conclusions
In this study, mental illness comorbidities predicted the interest to participate in digital mental therapy. Fragmented healthcare and perceptions of unmet care needs are likely contributor factors. Further research with a diverse sample of participants is necessary for generalizability. Findings may have important implications for healthcare best practices.
Assessing Lateralization Index of Adrenal Venous Sampling for Surgical Indication in Primary Aldosteronism
Authors: Kobayashi Hiroki , Nakamura Yoshihiro , Abe Masanori , Ragnarsson Oskar , Gkaniatsa Eleftheria , Grytaas Marianne Aa , Løvås Kristian , Wada Norio , Ichijo Takamasa , Heinrich Daniel A , Drake William , O’Toole Sam , Kocjan Tomaz , Kastelan Darko , Kraljevic Ivana , Yamamoto Koichi , Tsuiki Mika , Kloock Simon , Dischinger Ulrich , Parasiliti-Caprino Mirko , Sven Gruber , Spyroglou Ariadni , Furnica Raluca Maria , Fallo Francesco , Maiolino Giuseppe , Kometani Mitsuhiro , Wu Vin-Cent , Beuschlein Felix , Reincke Martin , Naruse Mitsuhide 
Published: May 2024

Abstract

Context
Clinical practice guidelines recommend the lateralization index (LI) as the standard for determining surgical eligibility in primary aldosteronism (PA).

Objective
Our goal was to identify the optimal LI cutoffs in adrenal venous sampling (AVS) for diagnosing PA that is amenable to surgical cure.

Methods
We conducted a retrospective international cohort study across 16 institutions in 11 countries, including 1550 patients with PA who underwent AVS, with and/or without adrenocorticotropin (ACTH) stimulation. The establishment of optimal cutoffs was informed by a survey of 82 patients with PA in Japan, aimed at determining the LI cutoff aligned with patient expectations for a surgical cure rate.

Results
The survey revealed that a median cure rate expectation of 80% would motivate patients with PA towards undergoing adrenalectomy. The optimal LI cutoffs achieving an adjusted positive predictive value (PPV) of 80% were identified as 3.8 for unstimulated AVS and 3.4 for ACTH-stimulated AVS. Furthermore, a contralateral ratio of less than 0.4 and the detection of an adrenal nodule on computed tomography imaging were identified as independent predictors of surgically curable PA. Incorporating these factors with the optimal LI cutoffs, the adjusted PPV increased to 96.6% for unstimulated AVS and 89.6% for ACTH-stimulated AVS. No clear differences in predictive ability between unstimulated and ACTH-stimulated LI were found.

Conclusion
The present study clarified the optimal LI cutoffs for without and with ACTH stimulation. The presence of contralateral suppression and adrenal nodule on CT imaging seems to provide additional available information besides LI for surgical indication.
Can Classical Athens Offer Lessons for a Large, Pluralistic Society?
Authors: Roberts Jennifer T. 
Published: May 2024

Abstract
Recoiling from the power that Athenian democracy placed in the hands of the poor, the founding fathers of the United States took Athens as primarily an anti-model, whereas nineteenth-century defenders of slavery found Athens a very congenial model indeed, seeming as it did to lend a mantle of legitimacy to an unspeakable practice. After a “honeymoon period” in which democracy was idealized as the only legitimate form of government, now at the outset of the twenty-first century the alliance of democracy with a capitalism that often proves heartless to the less fortunate has raised some troubling questions about democracy itself. Despite its small size, classical Athens offers valuable guidance for tempering current difficulties in both the United States and elsewhere by adopting and adapting the selection of some officials by sortition, direct election by popular vote of elected officials, a rigorous system of accountability, and the fostering of civic and community values.
Against Antiformalism
Authors: Braddick Michael 
Published: May 2024

Abstract
This contribution to the Common Knowledge symposium “Antipolitics” explores the place of legal agency in the political thought and activities of John Lilburne, one of the leading English Levellers of the seventeenth century. Protection of his rights as a freeborn Englishman was central to his political campaigns and political thought and was an important element of his published Leveller tracts. Much commentary on the Levellers has emphasized their demand for annual parliaments elected on a broad franchise and equal distribution of seats. But these constitutional arrangements were not an endorsement of ideals of universal suffrage, representative democracy, and majoritarianism but instead—along with legal agency—mechanisms for the protection of the people from tyranny. This overlooked feature of Leveller political thought may have something to teach us about the essential purposes of democracy in the face of majoritarian populism.
CEUS in diagnosis of renal masses
Authors: Ochyra Łukasz , Łopuszyńska Anna 
Published: May 2024

Introduction and purpose Contrast enhanced ultrasound (CEUS) is a modern diagnostic method that uses ultrasound waves in combination with intravenous administration of a contrast agent. It enables obtaining high resolution and assessing microcirculation in real time, thanks to which the researcher is able to analyze the enhancement and its features, which may help in diagnosing a specific pathology. Contrast agents, similar to CT and MRI, show specific phases of enhancement after administration - arterial, venous, delayed. Their additional advantage is safety, especially for patients with impaired kidney and thyroid function, and causing fewer allergic reactions. The aim of this review is to present the CEUS examination technique and the latest reports in the field of diagnosis of renal lesions. Material and methods This review was prepared based on the literature available from recent years in the PubMed and Google Scholar scientific databases using the keywords: ultrasonography, contrast enhanced ultrasonography, kidney, renal masses. Results Studies show that CEUS can be an effective method for imaging both cystic and solid lesions in the kidney. When using a contrast agent, the lesions show characteristic features that can guide the investigator to the diagnosis. Moreover, in comparative analyses, CEUS achieved comparable or better results than other diagnostic imaging methods. Conclusions CEUS is a modern and promising diagnostic method that can successfully compete with CT and MRI. Moreover, the metabolism and pharmacokinetics of contrast agents and their safety mean that CEUS can be used for the diagnosis of unclear pathologies in elderly patients, as well as for the control and supervision of changes that require frequent imaging. Keywords: ultrasonography, contrast enhanced ultrasonography, kidneys, renal masses