bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utility of IL‐36 immunostaining in distinguishing psoriasis from pityriasis rosea and pityriasis lichenoides
Authors: Ibraheim Marina Kristy , North Jeffrey P. 
Published: May 2024

AbstractBackgroundPsoriasis is an inflammatory skin disease driven by upregulation of cytokines in the Th17 pathway, including interleukin‐36 (IL‐36). Previous studies have highlighted the utility of IL‐36 immunostaining for psoriasis compared to spongiotic dermatitis and other psoriasiform dermatoses; however, no study has examined the role of IL‐36 staining in distinguishing psoriasis from pityriasis rosea (PR) and pityriasis lichenoides (PL), known histologic mimickers of psoriasis.MethodsWe compared the immunostaining pattern of IL‐36 for 21 PR cases, 22 PL cases, and 10 psoriasis cases. We graded the immunostaining as 0, negative; 1, focal weak; 2, diffuse weak; 3, focal, strong; or 4, diffuse strong. We further categorized stains as negative (0–2 score) or positive (3–4 score) and utilized Fisher's exact test to compare the immunostaining pattern of these entities.ResultsAll psoriasis specimens were positive for IL‐36, whereas all PR specimens were negative (p = 0.00000002). Twenty PL specimens were negative (p = 0.000001). Nine of 10 pityriasis lichenoides et varioliformis acuta cases were negative (p = 0.00012), and 11 of 12 cases of pityriasis lichenoides chronica were negative (p = 0.00003).ConclusionsOur findings highlight the potential role of IL‐36 immunostaining in distinguishing psoriasis from other psoriasiform dermatoses, including PR and PL.
Procalcitonin, brain natriuretic peptide and albumin as markers to predict prognosis in hospitalized older Japanese patients with a risk of infection
Authors: Higashikawa Toshihiro , Ito Toru , Ito Tomohiko , Mizuno Takuro , Ishigami Keiichirou , Kuroki Kengo , Maekawa Naoto , Usuda Daisuke , Yoshida Michiteru , Morita Takuro , Hamada Kazu , Yano Hiroshi , Takeshima Kento , Haraguchi Takatoshi , Yamada Shinya , Yamada Sohsuke , Ushimoto Tomoyuki , Sangen Ryusho , Izumida Toshihide , Kiyosawa Jun , Ono Taisuke , Iguchi Masaharu , Wato Yukihiro , Nakahashi Takeshi , Kasamaki Yuji , Fukuda Akihiro , Kanda Tsugiyasu , Morimoto Shigeto , Okuro Masashi 
Published: May 2024

AimWhether serum concentration of procalcitonin (PCT), brain natriuretic peptide (BNP) and albumin (Alb) have an association with the outcome of hospitalized older patients is unclear. We investigated clinical outcomes and any predictive factors in hospitalized Japanese older patients with a risk of infection.MethodsIn the retrospective study, 820 Japanese patients were followed up for 30 days or until death. During the observation period, 656 patients survived and 164 patients died. The predictive factors of death were analyzed according to demographic and clinical variables.ResultsThe survival rate was decreased as the serum PCT increased from <0.5 to ≥10 ng/mL, as was also the case with BNP from <300 to ≥300 pg./mL, whereas low Alb (<2.5 g/dL) showed a lower survival rate than high Alb (≥2.5 g/dL; P < 0.01). Using the Cox regression model, the multivariable‐adjusted hazard ratios (95% confidence interval) were as follows: PCT 0.5–2 versus <0.5 ng/mL: 1.61(1.04–2.49), PCT 2–10 versus <0.5 ng/mL: 1.91(1.15–3.16), PCT ≥10 versus <0.5 ng/mL: 2.90(1.84–4.59), high BNP 1.26 (0.89–1.76) and low Alb 0.68 (0.52–0.87). The mortality rate increased as the number of scores (PCT + BNP + Alb) increased.ConclusionsConcentration‐dependent high PCT, high BNP and low Alb were positive risk factors associated with poor prognosis in hospitalized older patients with a risk of infection. Geriatr Gerontol Int 2024; 24: 571–576.
Prevalence of people living with multidrug‐resistant HIV and limited treatment options in Spain
Authors: Llibre Josep M. , García Federico , Blanco José Luis , Peláez Esmeralda Palmier , de Cea Álvaro Mena , Cortés Luis López , Alonso Marta Montero , Bernáldez Miguel Pascual , Schroeder Melanie , Sánchez Silvia Esteban , Alcántara Felipe Rodríguez 
Published: May 2024

AbstractObjectivesOur aim was to determine the prevalence and characteristics of people with HIV on antiretroviral therapy (ART) with multidrug resistance (MDR; confirmed resistance to three or more [or resistance to two or more plus contraindication to one or more] core ART classes) and limited treatment options (LTOs) in Spain.MethodsThis was an observational, retrospective, multicentre, cross‐sectional chart review study undertaken in five reference Spanish centres. Participants were people with HIV on ART with MDR and LTOs (detectable viral load [HIV‐RNA >200 copies/mL], treatment‐limiting drug–drug interaction [DDI], or intolerance precluding the use of one or more ART classes). Prevalence, demographic/clinical characteristics, and treatment options were assessed. Logistic regression analyses were used to identify MDR‐associated variables.ResultsOf 14 955 screened people with HIV, 69 (0.46%) presented with MDR and 23 (0.15%) had LTOs. The population analysed was 73.9% male with a median age of 54.0 years; the median time since HIV diagnosis was 26.5 years, and median CD4+ cell count was 511.0 cells/μL. The only factor significantly associated with MDR (univariate analysis) was CD4+ cell count. Injection drug use was the most common transmission route. Comorbidities (mainly endocrine and cardiovascular disorders; 34.8% affecting HIV management) and concomitant treatments were frequent. No recent opportunistic infections were reported. Patients had been exposed to the following ART: nucleoside analogue reverse transcriptase inhibitors (100%), protease inhibitors (95.6%), non‐nucleoside analogue reverse transcriptase inhibitors (87.0%), and integrase strand transfer inhibitors (82.6%). The available fully active drugs were dolutegravir (39.1%), bictegravir (30.4%), and raltegravir (21.7%).ConclusionsThe prevalence of people with HIV with MDR and LTOs in Spain is very low, with approximately half of those studied not exhibiting virological suppression. Low CD4+ cell counts were associated with MDR. These findings may help address the impact and treatment needs of these patients and prevent clinical progression and transmission of MDR HIV.
Electrochemical corrosion and tribocorrosion behavior of CrN and CrAlN coatings in artificial seawater
Authors: Bai Xiao , Li Yang , Guo Chunting , Man Jia , Zhang Dejian , Wan Yong , Sun Huilai 
Published: May 2024

AbstractThis study investigated the corrosion and tribocorrosion behavior of CrN and CrAlN coatings deposited on steel through direct current magnetron sputtering. Additionally, the effects of Al addition on the microstructure, corrosion inhibition, and tribocorrosion behavior of CrN coatings were evaluated. Compared with the CrN coating, the CrAlN coating exhibited a denser columnar crystal structure and a higher hardness of 23.8 GPa. The CrAlN coating reacted with water to form Al2O3 and Cr2O3 films, which enhanced its corrosion resistance. Moreover, the addition of Al enhanced the wear resistance of the CrN coating and reduced the material loss due to corrosion, wear, and their synergistic effects. The CrAlN coating exhibited a low corrosion current density of 1.14 × 10−8 A/cm2, indicating a 92% reduction compared with the CrN coating. Furthermore, under either open circuit potential or anodic accelerated tribocorrosion conditions, the CrAlN coating featured significantly lower total material loss and synergistic material loss than the CrN coating, demonstrating higher corrosion and tribocorrosion protection.
Listening to Black Women's Perspectives of Birth Centers and Midwifery Care: Advocacy, Protection, and Empowerment
Authors: Anyiam Shalom , Woo Jennifer , Spencer Becky 
Published: May 2024

IntroductionBlack women in Texas experience high rates of adverse maternal outcomes that have been linked to health inequities and structural racism in the maternal care system. Birth centers and midwifery care are highlighted in the literature as contributing to improved perinatal care experiences and decreased adverse outcomes for Black women. However, compared with White women, Black women underuse birth centers and midwifery care. Black women's perceptions in Texas of birth center and midwifery care are underrepresented in research. Thus, this study aimed to highlight the views of Black women residing in Texas on birth centers and midwifery care to identify their needs and explore ways to increasing access to perinatal care.MethodsSemistructured interviews were conducted with 10 pregnant and postpartum Black women residing in Texas. Questions focused on the women's access, knowledge, and use of birth centers and midwifery care in the context of their lived maternal care experiences. Interview transcripts were reviewed and analyzed using inductive, qualitative content analysis.ResultsThe Black women interviewed all shared experiences of discrimination and bias while receiving obstetric care that affected their interest in and overall perceptions of birth center and midwifery care. Participants also discussed financial and institutional barriers that impacted their ease of access to birth center and midwifery care services. Additionally, participants highlighted the need for culturally sensitive and respectful perinatal health care.DiscussionThe Black women interviewed in this study emphasized the prevalence of racism and discrimination in perinatal health care encounters, a reflection consistent with current literature. Black women also expressed a desire to use birth centers and midwifery care but identified the barriers in Texas that impede access. Study findings highlight the need to address barriers to promote equitable perinatal health care access for Black women.
Translational validity of neuropsychological tasks of sustained attention between rodents and humans: A systematic review of three rodent tasks
Authors: Salmon Claire , Li Shuting , Burrows Emma L. , Johnson Katherine A. 
Published: May 2024

AbstractAtypical sustained attention is a symptom in a number of neurological and psychological conditions. Investigations into its neural underpinnings are required for improved management and treatment. Rodents are useful in investigating the neurobiology underlying atypical sustained attention and several rodent tasks have been developed for use in touchscreen testing platforms that mimic methodology used in human clinical attention assessment. This systematic review was conducted to assess how translatable these rodent tasks are to equivalent clinical human tasks. Studies using the rodent Continuous Performance Task (rCPT), Sustained Attention Task (SAT), and 5‐choice CPT (5C‐CPT) were sought and screened. Included in the review were 138 studies, using the rCPT (n = 21), SAT (n = 90), and 5C‐CPT (n = 27). Translatability between rodent and human studies was assessed based on (1) methodological similarity, (2) performance similarity, and (3) replication of results. The 5C‐CPT was found to be the most translatable cross‐species paradigm with good utility, while the rCPT and SAT require adaptation and further development to meet these translatability benchmarks. With greater replication and more consistent results, greater confidence in the translation of sustained attention results between species will be engendered.image
Particularity, Engagement, Actionable Inferences, Reflexivity, and Legitimation tool for rigor in mixed methods implementation research
Authors: Younas Ahtisham , Fàbregues Sergi 
Published: May 2024

AbstractBackgroundImplementation science helps generate approaches to expedite the uptake of evidence in practice. Mixed methods are commonly used in implementation research because they allow researchers to integrate distinct qualitative and quantitative methods and data sets to unravel the implementation process and context and design contextual tools for optimizing the implementation. To date, there has been limited discussion on how to ensure rigor in mixed methods implementation research.PurposeTo present Particularity, Engagement, Actionable Inferences, Reflexivity, and Legitimation (PEARL) as a practical tool for understanding various components of rigor in mixed methods implementation research.Data SourcesThis methodological discussion is based on a nurse‐led mixed methods implementation study. The PEARL tool was developed based on an interpretive, critical reflection, and purposive reading of selected literature sources drawn from the researchers' knowledge, experiences of designing and conducting mixed methods implementation research, and published methodological papers about mixed methods, implementation science, and research rigor.ConclusionAn exemplar exploratory sequential mixed methods study in nursing is provided to illustrate the application of the PEARL tool. The proposed tool can be a useful and innovative tool for researchers and students intending to use mixed methods in implementation research. The tool offers a straightforward approach to learning the key rigor components of mixed methods implementation research for application in designing and conducting implementation research using mixed methods.Clinical RelevanceRigorous implementation research is critical for effective uptake of innovations and evidence‐based knowledge into practice and policymaking. The proposed tool can be used as the means to establish rigor in mixed methods implementation research in nursing and health sciences.
Machine learning models for prediction of postoperative venous thromboembolism in gynecological malignant tumor patients
Authors: Lin Bijuan , Chen Fang , Wu Meiying , Li Chaojing , Lin Lanzhi 
Published: May 2024

AbstractAimTo identify risk factors that associated with the occurrence of venous thromboembolism (VTE) within 30 days after hysterectomy among gynecological malignant tumor patients, and to explore the value of machine learning (ML) models in VTE occurrence prediction.MethodsA total of 1087 patients between January 2019 and January 2022 with gynecological malignant tumors were included in this single‐center retrospective study and were randomly divided into the training dataset (n = 870) and the test dataset (n = 217). Univariate logistic regression analysis was used to identify risk factors that associated with the occurrence of postoperative VTE in the training dataset. Machine learning models (including decision tree (DT) model and logistic regression (LR) model) to predict the occurrence of postoperative VTE were constructed and internally validated.ResultsThe incidence of developing 30‐day postoperative VTE was 6.0% (65/1087). Age, previous VTE, length of stay (LOS), tumor stage, operative time, surgical approach, lymphadenectomy (LND), intraoperative blood transfusion and gynecologic Caprini (G‐Caprini) score were identified as risk factors for developing postoperative VTE in gynecological malignant tumor patients (p < 0.05). The AUCs of LR model and DT model for predicting VTE were 0.722 and 0.950, respectively.ConclusionThe ML models, especially the DT model, constructed in our study had excellent prediction value and shed light upon its further application in clinic practice.
The Earth atmosphere‐like bulk nitrogen isotope composition obtained by stepwise combustion analyses of Ryugu return samples
Authors: Hashizume Ko , Ishida Akizumi , Chiba Ayano , Okazaki Ryuji , Yogata Kasumi , Yada Toru , Kitajima Fumio , Yurimoto Hisayoshi , Nakamura Tomoki , Noguchi Takaaki , Yabuta Hikaru , Naraoka Hiroshi , Takano Yoshinori , Sakamoto Kanako , Tachibana Shogo , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Abe Masanao , Okada Tatsuaki , Usui Tomohiro , Yoshikawa Makoto , Saiki Takanao , Terui Fuyuto , Tanaka Satoshi , Nakazawa Satoru , Watanabe Sei‐ichiro , Tsuda Yuichi , Broadley Michael W. , Busemann Henner ,   the Hayabusa2 Initial Analysis Volatile Team
Published: May 2024

AbstractThe nitrogen isotope compositions of two samples returned from the asteroid Ryugu were determined using a stepwise combustion method, along with Ivuna (CI) and Y‐980115, a CI‐like Antarctic meteorite, as references. The two Ryugu samples A0105‐07 and C0106‐07 showed bulk δ15N values of +1.7 ± 0.5‰ and +0.2 ± 0.6‰, respectively, significantly lower than Ivuna with +36.4 ± 0.4‰, but close to Y‐980115 with +4.0 ± 0.3‰. The Ryugu samples are further characterized by C/N and 36Ar/N ratios up to 3.4× and 4.9× the value of Ivuna, respectively. Among all Ryugu samples and CI chondrites, a positive correlation was observed between nitrogen concentrations and δ15N values, with samples with lower nitrogen concentrations exhibiting lower δ15N. This trend is explained by a two‐component mixing model. One component is present at a constant abundance among all CI‐related samples, with a δ15N value around 0‰ or lower. The other varies in abundance between different samples, and exhibits a δ15N value of +56 ± 4‰. The first 15N‐poor endmember is seemingly tightly incorporated into a carbonaceous host phase, whereas the 15N‐rich endmember can be mobilized and decoupled from carbon, potentially because it is in the form of ammonia. Asteroid materials with volatile compositions that are similar to those reported here for the Ryugu samples are attractive candidates for the volatile sources among Earth's building blocks.
Israeli Hydro‐Hegemony and the Gaza War
Authors: Seeberg Peter 
Published: May 2024

AbstractThis article analyzes the vicious cycle of Israel's control of water resources in Jordan and the Palestinian territories, the development of a one‐state reality in the region, and geopolitical changes driven by the Israeli occupation and the war in Gaza. Israel no longer suffers from water shortages, but its domination of Palestine and the conflict sparked by Hamas have increased the yawning water deficit. This has played a role in the decades‐long move away from the two‐state solution promised by the Oslo peace process. This article examines regional security through the lens of water resources. It shows that Jordan is left with few options but to accept its dependence on Israel and muddle through. In addition, the Palestinian territories, which face not just Israeli military rule but also the expansion of settlements, experience major water shortages. The article concludes that the increasing water hegemony reduces Israeli incentives for a comprehensive peace with the Palestinians that could resolve the resource crisis and enable two states to live side by side.
Significant Association of Serum Albumin With the Severity of Coronary Microvascular Dysfunction Using Dynamic CZT‐SPECT
Authors: Chien Shih‐Chieh , Wang Shan‐Ying , Tsai Cheng‐Ting , Shiau Yu‐Chien , Wu Yen‐Wen 
Published: May 2024

ABSTRACTObjectiveBoth low serum albumin (SA) concentration and coronary microvascular dysfunction (CMD) are risk factors for the development of heart failure (HF). We hypothesized that SA concentration is associated with myocardial flow reserve (MFR) and implicated in pathophysiological mechanism of HF.MethodsWe retrospectively studied 454 patients undergoing dynamic cardiac cadmium‐zinc‐telluride myocardial perfusion imaging from April 2018 to February 2020. The population was categorized into three groups according to SA level (g/dL): Group 1: >4, Group 2: 3.5–4, and Group 3: <3.5. Myocardial blood flow (MBF) and myocardial flow reserve (MFR, defined as stress/rest MBF ratio) were compared.ResultsThe mean age of the whole cohort was 66.2 years, and 65.2% were men. As SA decreased, stress MBF (mL min−1 g−1) and MFR decreased (MBF: 3.29 ± 1.03, MFR: 3.46 ± 1.33 in Group 1, MBF: 2.95 ± 1.13, MFR: 2.51 ± 0.93 in Group 2, and MBF: 2.64 ± 1.16, MFR: 1.90 ± 0.50 in Group 3), whereas rest MBF (mL min−1 g−1) increased (MBF: 1.05 ± 0.42 in Group 1, 1.27 ± 0.56 in Group 2, and 1.41 ± 0.61 in Group 3). After adjusting for covariates, compared with Group 1, the odds ratios for impaired MFR (defined as MFR < 2.5) were 3.57 (95% CI: 2.32–5.48) for Group 2 and 34.9 (95% CI: 13.23–92.14) for Group 3. The results would be similar if only regional MFR were assessed. The risk prediction for CMD using SA was acceptable, with an AUC of 0.76.ConclusionLow SA concentration was associated with the severity of CMD in both global and regional MFR as well as MBF.
UDP‐glycosyltransferase UGT96C10 functions as a novel detoxification factor for conjugating the activated dinitrotoluene sulfonate in switchgrass
Authors: Su Kunlong , Wu Zhenying , Liu Yuchen , Wang Yan , Wang Han , Liu Meifeng , Wang Yu , Wang Honglun , Fu Chunxiang 
Published: May 2024

SummaryDinitrotoluene sulfonates (DNTSes) are highly toxic hazards regulated by the Resource Conservation and Recovery Act (RCRA) in the United States. The trinitrotoluene (TNT) red water formed during the TNT purification process consists mainly of DNTSes. Certain plants, including switchgrass, reed and alfalfa, can detoxify low concentrations of DNTS in TNT red water‐contaminated soils. However, the precise mechanism by which these plants detoxify DNTS remains unknown. In order to aid in the development of phytoremediation resources with high DNTS removal rates, we identified and characterized 1‐hydroxymethyl‐2,4‐dinitrobenzene sulfonic acid (HMDNBS) and its glycosylated product HMDNBS O‐glucoside as the degradation products of 2,4‐DNT‐3‐SO3Na, the major isoform of DNTS in TNT red water‐contaminated soils, in switchgrass via LC–MS/MS‐ and NMR‐based metabolite analyses. Transcriptomic analysis revealed that 15 UDP‐glycosyltransferase genes were dramatically upregulated in switchgrass plants following 2,4‐DNT‐3‐SO3Na treatment. We expressed, purified and assayed the activity of recombinant UGT proteins in vitro and identified PvUGT96C10 as the enzyme responsible for the glycosylation of HMDNBS in switchgrass. Overexpression of PvUGT96C10 in switchgrass significantly alleviated 2,4‐DNT‐3‐SO3Na‐induced plant growth inhibition. Notably, PvUGT96C10‐overexpressing transgenic switchgrass plants removed 83.1% of 2,4‐DNT‐3‐SO3Na in liquid medium after 28 days, representing a 3.2‐fold higher removal rate than that of control plants. This work clarifies the DNTS detoxification mechanism in plants for the first time, suggesting that PvUGT96C10 is crucial for DNTS degradation. Our results indicate that PvUGT96C10‐overexpressing plants may hold great potential for the phytoremediation of TNT red water‐contaminated soils.