bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analyzing the impact of bounded degree constraints on computational complexity of argumentation frameworks
Authors: Elaroussi Mohammed 
Published: February 2025

This research explores the relationship between the bounded in-degree and out-degree of an argumentation framework and the computational complexity of the problems of Credulous Acceptance ( CredA ) and Skeptical Acceptance ( SkepA ) under preferred extensions. Researchers have studied the complexity of these problems when the in-degree [Formula: see text] and out-degree [Formula: see text] of the arguments are restricted to [Formula: see text]. Despite this restriction, the computational complexities of CredA and SkepA persist. Based on these results, we presents new results that provide deeper insights into the impact of additional constraints on the argumentation framework. Specifically, we show that when “[Formula: see text]” or “[Formula: see text]” is restricted to [Formula: see text], both problems CredA and SkepA can be solved in polynomial time. Subsequently, we impose additional constraints on the argumentation framework by analyzing the quantities “[Formula: see text],” “[Formula: see text],” and “[Formula: see text].” For an argumentation framework [Formula: see text] and all arguments “[Formula: see text]” of [Formula: see text], the parameter “[Formula: see text]” indicates the maximum number of attackers that any argument “[Formula: see text]” can have among all those that are not attacked by “[Formula: see text]” [Formula: see text], “[Formula: see text]” indicates the maximum number of arguments that any argument “[Formula: see text]” attacks among all those that do not attack “[Formula: see text]”, and “[Formula: see text]” denotes the maximum number of arguments that any argument “[Formula: see text]” attacks among those that attack “[Formula: see text]”. Surprisingly, even when all these quantities are restricted to [Formula: see text], the computational complexity of CredA persists. Furthermore, we explore the influence of symmetric attacks by fixing “[Formula: see text]” to zero, while setting “[Formula: see text]” and “[Formula: see text]” to [Formula: see text]. Remarkably, the complexity of CredA persists under this restriction as well.
Relationship of sKlotho with hemoglobin level in patients undergoing maintenance hemodialysis: a case–control study
Authors: Liu Qi-Feng , Sun Zhuo-Yi , Tang Xiao-Fang , Yu Li-Xia , Li Sha-Sha 
Published: February 2025

Background: Klotho is a kidney-derived protein that is involved in various kidney diseases. The role of serum soluble Klotho (sKlotho) in the anemia of patients undergoing hemodialysis has not been well characterized. Objective: We aimed to characterize the relationship between sKlotho and hemoglobin (Hb) levels in this group of patients. Design: A single-center cross-sectional study of 208 patients undergoing maintenance hemodialysis (MHD) and 50 healthy controls was performed between June 1 and 31, 2023. Methods: Demographic information and biomedical parameters, such as age, body mass index, medication use, and their Hb, albumin, interleukin-6, and sKlotho concentrations, were obtained. Patients undergoing MHD were allocated to a group that achieved the Hb target (⩾110 g/L) and a group that did not (<110 g/L). Correlation analysis and multivariate logistic and linear regression analyses were performed to evaluate the relationship of sKlotho with Hb concentration. Results: Participants undergoing MHD had lower Hb and sKlotho concentrations than controls. Those who had not achieved the target Hb level were given fewer erythropoiesis-stimulating agents and had lower sKlotho and albumin concentrations, but higher interleukin-6 concentrations, than those who had achieved the Hb target. The sKlotho concentration positively correlated with the Hb concentration and was inversely associated with the incidence of a lack of achievement of the target Hb level. Multivariate logistic regression models revealed that there was a close association between sKlotho and a lack of achievement of the target Hb level after adjustment for potential confounders (odds ratio: 0.335, 95% confidence interval: 0.142–0.791, p = 0.013). This relationship was closer on multivariate linear regression analysis when sKlotho was included as a continuous variable. Conclusion: The circulating sKlotho concentration is very low, but deficiency of this protein is independently associated with a high risk of anemia in patients undergoing MHD. Therefore, the routine monitoring of sKlotho concentration might be useful in the management of renal anemia in such patients.
A model for predicting factors affecting health information avoidance on WeChat
Authors: Chen Minghong , Huang Xiumei , Wu Yinger , Song Shijie , Qi Xianjun 
Published: February 2025

Objective WeChat serves as a crucial source of health information, distinguished by its highly personalized nature. Avoidance of such personalized health information has a direct impact on individuals’ health decision-making. This study aims to identify the factors influencing personalized health information avoidance on WeChat and to construct a hierarchical framework illustrating the relationships among these factors. Methods A hybrid method was utilized. Semi-structured interviews and grounded theory were used to identify the influencing factors. The interpretive structural modeling (ISM) method was adopted to develop a hierarchical model of the identified factors, followed by matrice d'impacts croises-multiplication appliqué a un classemen (MICMAC) to analyze the dependence and driving power of each factor. Results The 20 predictors of personalized health information avoidance were broadly categorized into three groups: personal, informational, and social factors. These factors collectively form a three-tier explanatory framework, consisting of the top, middle and bottom layers. At the root layer, health characteristics and cognition exerted a strong driving force, while negative emotions and affective factors at the top layer showed a high degree of dependence. In contrast, the decision-making cognition, informational factors, and social factors in the middle layer exhibited relatively weaker driving force and dependence power. Conclusion This study bridged the research gap of information avoidance by providing new insights targeting the factors influencing personalized health information avoidance behavior on WeChat. It also contributed to enhancing personal health information management and the health information services provided on WeChat.
Physical activity as a predictor of fremanezumab response in chronic migraine – the Phy-Fre-Mig study
Authors: Sierra-Mencía Álvaro , Recio-García Andrea , García-Azorín David , de la Torre Antonio José Molina , González Isabel Ros , Guerrero-Peral Ángel Luis 
Published: February 2025

Abstract

Background
The relationship between physical activity (PA) and migraine is insufficiently understood. Studies have not analysed levels of PA or Time Sitting (TS) during preventive treatment, nor the role these might play in the response to preventive treatment.

Methods
An observational, longitudinal prospective study in a headache clinic was conducted. All consecutive chronic migraine patients initiating fremanezumab were invited to participate and were followed for three visits. The International Physical Activity Questionnaire (IPAQ) - long version was used.

Results
Seventy-six patients with a median of 46 years old, 84.2% female were enrolled. One month after fremanezumab administration, there was a significant increase of most PA variables and a significant decrease in TS levels compared with baseline; headache days and walking, TS and migraine days showed a moderate correlation. Three months after initiation, all PA variables statistically increased and TS levels statistically decreased, and variables such as headache/migraine days showed a moderate correlation with all PA variables analysed. In the multivariate analysis, higher levels of walking at baseline were independently associated with response to fremanezumab (ORa: 1.194; CI: 1.018–1.401, p = 0.029).

Conclusion
Patients who spent more time walking before starting treatment, were more likely to have a response to fremanezumab. PA and TS levels changed since the first month and correlated with clinical variables.
Women’s health and healthcare experiences in the years after gestational diabetes or hypertensive disorders of pregnancy
Authors: Jenkinson Bec , Charlton Valerie , Hardiman Leah , Limmer Ayme , McKenzie Melanie , Ura Anna-Lee , Bonner Carissa , Lawler Sheleigh , Middleton Philippa , Mishra Gita , Doust Jenny 
Published: February 2025

Abstract

Background
Pregnancy complications, such as gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP), affect a significant proportion of women in Australia, with long-term implications for cardiovascular disease (CVD) risk. Despite existing preventive measures, participation in ongoing health monitoring remains low. This study aims to explore women’s preferences and experiences regarding preventive healthcare after GDM and HDP, and to identify their unanswered questions about the association between these conditions and future CVD risk.

Methods
A participatory, qualitative approach was adopted, involving a Lived Experience Expert Group (LEE Group) to plan, conduct, and interpret focus groups with women who had experienced either GDM or HDP. Participants were recruited through health consumer and community organisations and took part in two focus groups conducted via Zoom. The focus groups involved a stimulus presentation about CVD and GDM or HDP, facilitated group discussion about participants’ health and healthcare since their pregnancy, and Nominal Group Technique to prioritise participants’ questions about their CVD risk. Focus groups were audio recorded and transcripts from each group were analysed thematically. Synthesised Member Checking was used to verify the trustworthiness of findings.

Results
Twelve women participated in the focus groups, with distinct themes emerging from the GDM and HDP focus groups. Participants were previously unaware of the association between their pregnancy complication and increased risk of future CVD and wished to know more. Three themes were generated from the GDM focus groups: ‘a distressing diagnosis’; ‘degrees of diabetes’; and ‘balancing motherhood and self-care’. Two themes were generated from the HDP focus groups: ‘women’s concerns were dismissed’ and ‘wanting follow up at the right time and with the right person’. The ‘top ten’ questions from each group focussed on improving maternity care, preventing CVD, and (for the HDP group) concerns beyond CVD.

Conclusions
Women’s capacity to engage in preventive health after GDM and HDP is influenced by their maternity care experiences and the accessibility of primary care pathways. Future interventions should focus on improving woman-centred maternity care, ensuring seamless transitions to primary care, and addressing the social determinants of health for new mothers.
Rates of mental health concerns among individuals assessed at the GoodHope Ehlers-Danlos Syndrome Clinic
Authors: Slepian P. Maxwell , Axenova Kristina , McCarthy Molly , Siegal Rachel , Gobin Keisha , Weinrib Aliza , Buryk-Iggers Stephanie , Santa Mina Daniel , McGillis Laura , Mittal Nimish , Katz Joel , Clarke Hance 
Published: February 2025

Abstract
Past research has indicated that individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobililty Spectrum Disorder (G-HSD) report psychological and psychiatric symptoms, particularly anxiety disorders and depressive symptoms, at much greater rates than the general population. However, these studies have been primarily conducted in small samples at European centres. We report a retrospective chart review from 1035 consecutive patients (88% female) assessed for EDS/G-HSD at the GoodHope EDS Clinic at Toronto General Hospital between June 2019 and June 2021. Prior to assessment, all patients completed self-reported mental health screening questions, the Inventory of Depressive and Anxiety Symptoms – Dysphoria scale, and the Borderline Symptom List-23. The majority of patients reported current or past anxiety or depressive symptoms (53–87%), and a substantial minority reported significant mental health concerns, including Posttraumatic Stress Disorder (4.7–34.8%), disordered eating (19%), self-harm (3-29.2%), and suicidal behaviour (7.8–18.6%). Patients did not differ by diagnostic category on self-report measures of dysphoria or borderline symptoms. Individuals with G-HSD reported higher rates of anxiety and depression in clinical interview than those diagnosed with non-hypermobile EDS, and endorsed a higher rate of having “struggled with anxiety or depression” on the mental health screening questionnaire than individuals not diagnosed with EDS/G-HSD. No other differences emerged across diagnostic groups. These findings highlight the need for psychological support for individuals with EDS or G-HSD.
Bovine milk-derived extracellular vesicles reduce oxidative stress and ferroptosis induced by Klebsiella pneumoniae in bovine mammary epithelial cells
Authors: Liang Bingchun , Xiong Yindi , Cobo Eduardo R. , Kastelic John , Tong Xiaofang , Han Bo , Gao Jian 
Published: February 2025

Abstract

Background
Ferroptosis is characterized by increased production of reactive oxygen species (ROS) and membrane lipid peroxidation that can exacerbate inflammatory damage. Extracellular vesicles (EVs) isolated from bovine milk have many biological functions, including antioxidant properties. However, the role of EVs on Klebsiella pneumoniae-induced ferroptosis and oxidative stress in bovine mammary epithelial cells (bMECs) and murine mammary tissue is unclear. In this study, EVs were isolated from bovine colostrum, mature milk and clinical mastitis milk (defined as C-EVs, M-EVs and CM-EVs, respectively) and assessed by transmission electron microscopy, Western blot and transcriptome sequencing. Effects of EVs on K. pneumoniae-induced ferroptosis and oxidative stress in bMECs were evaluated with immunofluorescence and Western blot.

Results
In bMECs, infection with K. pneumoniae induced oxidative stress, decreasing protein expression of Nrf2, Keap1 and HO-1 plus SOD activity, and increasing ROS concentrations. However, protein expression of GPX4, ACSL4 and S100A4 in bMECs, all factors that regulate ferroptosis, was downregulated by K. pneumoniae. Furthermore, this bacterium compromised tight junctions in murine mammary tissue, with low expression of ZO-1 and Occludin, whereas protein expression of Nrf2 and GPX4 was also decreased in mammary tissue. Adding C-EVs, M-EVs or CM-EVs reduced oxidative stress and ferroptosis in K. pneumoniae-infected bMECs in vitro and murine mammary tissues in vivo.

Conclusion
In conclusion, all 3 sources of milk-derived EVs alleviated oxidative stress and ferroptosis in K. pneumoniae-infected bMECs and mammary tissues.
In situ analysis of soluble organic compounds in Hayabusa Category 3 particles
Authors: Hashiguchi Minako , Naraoka Hiroshi , Uesugi Masayuki , Yada Toru , Abe Masanao 
Published: February 2025

Abstract
In this study, two Category 3 carbonaceous particles (RB-CV-0008 and RB-CV-0031) among more than 700 Hayabusa-returned particles were analyzed by molecular imaging using desorption electrospray ionization–high-resolution mass spectrometry (desorption electrospray ionization (DESI)–high-mass-resolution mass spectrometry (HRMS)) with an electrically charged methanol spray. RB-CV-0031 was unfortunately lost during the analysis; however, 176 positive ions (m/z 70–1000) were successfully identified from the surface of RB-CV-0008. The chemical compositions of these ions were assigned using their exact masses, and CHNO and CHO compounds were abundant in both number and total ion intensity. The ions showed varying spatial distributions, which could be classified into six patterns, and their chemical compositions were different between the distribution patterns. Furthermore, the ions were predominantly detected from the region surrounding the main body of the particle, where tiny particles that were likely broken up during handling were observed. This result suggests that RB-CV-0008 consists of more than two materials with different solubilities in methanol. Furthermore, several homologous compounds containing the C3H6O unit (at 58.0418 amu) were found in the identified ions from RB-CV-0008 using a mass defect (MD) plot. Among the possible contaminants analyzed in this study, the features of the positive ions identified by DESI–HRMS imaging and energy-dispersive spectroscopy (EDS) of RB-CV-0008 most closely resembled those of Nylon-6. These results suggest that some of the moieties, including the side chains corresponding to the C3H6O unit of RB-CV-0008, resembled those of Nylon-6 and polypropylene glycol (PPG), but the carbon skeleton differed between RB-CV-0008 and those materials. Our results indicate that RB-CV-0008 likely contains a mixture of different materials, such as polyamide and PPG. This study represents first comprehensive investigation of the soluble organic matter (SOM) characteristics of Category 3 particles by in situ analysis. The spatial distribution and ion species detected in this study indicate that the RB-CV-0008 particles have heterogeneous moieties with different solubilities in methanol and/or ionization efficiency and different chemical compositions. This study supports previous studies suggesting that Category 3 particles are derived from terrestrial materials and have multiple origins.

Graphical Abstract
SREBF1, a target gene of multiple sclerosis and coronary heart disease: based on mendelian randomization study
Authors: Du Linqin , Cui Yangyang , Zhou Yang , Kwaku Ofe Eugene , Ding Xuefeng , Zeng Lang , Li Shikang , Xiong Lijuan , Zhang Yonghong , Zhou Peng , Wang Kun , Yue Rongchuan 
Published: February 2025

Abstract

Background and purpose
Research shows that people with multiple sclerosis (MS) are more likely to experience cardiovascular complications. However, the precise mechanisms underlying this association remain unclear. This study investigated the causal relationship between MS and coronary heart disease (CHD) using Mendelian randomization (MR) techniques to clarify direct effects and identify relevant target genes.

Methods
We conducted various methods, including two-sample MR. method, reverse, and multivariable MR analyses, to examine the causal relationship between MS and CHD. These. methodologies effectively mitigate confounding variables and neutralize adverse causal effects. Additionally, the study explored the involvement of social factors through a two-step MR analysis. The research team performed a thorough screening of differentially expressed genes in MS based on GEO database, identifying potential target genes that may be associated with genetic risk of CHD. Enrichment analyses and protein-protein interaction studies were used to elucidate biological functions associated with these genes. We included colocalization analysis and summary data-based Mendelian randomization (SMR) method for further screening of core genes to obtain target genes.Finally, we investigated how these genes might affect health by conducting a phenome-wide MR analysis.

Results
Our findings revealed that genetic predisposition to MS significantly increases the risk of CHD, with an IVW-MR analysis yielding an odds ratio of 1.091 (95% CI: 1.030, 1.155, P = 0.0029). Mediation analysis revealed that frailty mediated 20.2% of the effect of MS on CHD (P = 0.026), suggesting that frailty is a critical pathway in this relationship. Additionally, low-density lipoprotein (LDL) is associated with an increased risk of developing both MS and CHD. We identified 3025 differentially expressed genes and 130 genes causally linked to CHD. Protein-protein interaction network analysis identified 77 interacting genes, with core genes such as SREBF1 involved in organelle regulation and nucleic acid metabolism. Colocalization analysis further supported the presence of shared genetic variants between IL6R and SREBF1 associated with CHD, with posterior probabilities (PPH4) of 90.2% and 92.3%, respectively. Interestingly, summary mendelian randomization (SMR) analysis revealed that SREBF1 may be a target gene for MS(bSMR=-0.174,PSMR = 0.0218, PHEIDI = 0.2806, topSNP: rs12951376). Further analysis of the phenome-wide MR did not find significant evidence of side effect associated with targeted therapy against SREBF1.

Conclusion
This study provided genetic evidence indicating that indivduals with MS face higher risk of coronary heart disease. Furthermore, SREBF1 maybe a critical target gene which would significantly contribute to drug development.
Research on construction risk assessment method of shield tunnel based on subjective and objective weights
Authors: Zheng Yuanxun , Li Fengwei , Guo Huiji , Chen Jing , Wu Jingjiang 
Published: February 2025

Abstract
Various risks often exist in metro construction and building, and how to assess the risk when metro is constructed by shield method and establish the construction risk indicator system has become a hot research topic nowadays. In this paper, HHM (hierarchical holography method) is firstly used to list the initial 26 risk indicators, and the risk list is optimized by using vague set theory to get 13 risk indicators. Then, the risk indicators are assigned by a combination of the G1 method (order-relationship hierarchy method) and the COWA method (order-weighted average operator) to determine the weights of the construction safety risk evaluation indicators of the shield construction method of metro tunnels. At the same time, to reduce the influence of the uncertainty, randomness and ambiguity of the shield construction of metro tunnels and more intuitively represent the risk weights of the indicators, and the cloud theory is used to objectively display the risk weights of the indicators. Finally, the subway tunnel shield method construction safety risk evaluation model introduced into the Tianjin Metro an interval case for risk assessment, and test of the scientific nature of the model, applicability, the evaluation results obtained, and the actual results are consistent with the validation of this paper to build the subway tunnel shield method construction safety risk evaluation model of scientific applicability and reliability, enriching the subway tunnel engineering construction safety risk evaluation method for subway tunnels. Construction safety risk evaluation provides a scientific basis for decision-making, but also for the further development of risk prevention measures, reduces the risk of construction of subway tunneling projects to provide a basis for promoting the healthy and rapid development of the construction of urban subways, and provides guidance for similar projects.
O outro lado da metáfora
Authors: Figueira Filipo 
Published: February 2025

Neste ensaio teórico, pretende-se dar continuidade às considerações tecidas anteriormente sobre o “ordinário do sentido”, como este conceito aparece no pensamento de Michel Pêcheux. Propõe-se uma forma de dar consequências à necessidade de pensar a práxis dentro de uma teoria discursiva do sentido e da linguagem através da reinterpretação do “primado da metáfora”, princípio semântico que sustenta a Análise do Discurso desenvolvida por ele. Defende-se, assim, que de dentro da própria proposição do “primado da metáfora”, o “efeito de sentido” pode então ser melhor compreendido como um laborioso esforço para fazer sentido, também fazendo aí intervirem as reflexões sobre a possibilidade de uma performatividade do discurso. Caminha-se, portanto, na direção da hipótese da materialidade prática do sentido, evidenciando o papel teórico do fazer discursivo do sujeito com a língua.