bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polarimetric Radar–Based Estimates of Spatial Variability in Characteristic Sizes of Raindrops in Stratiform Rainfall
Authors: Matrosov Sergey Y. 
Published: July 2011

AbstractPolarimetric X-band radar measurements of differential reflectivity ZDR in stratiform rainfall were used for retrieving mean mass-weighted raindrop diameters Dm and estimating their spatial variability δDm at different scales. The ZDR data were calibrated and corrected for differential attenuation. The results revealed greater variability in Dm for larger spatial scales. Mean values of δDm were respectively around 0.32–0.34, 0.28–0.30, and 0.24–0.26 mm at scales of 20, 10, and 4.5 km, which are representative of footprints of various spaceborne sensors. For a given spatial scale, δDm decreases when the mean value of Dm increases. At the 20-km scale the decreasing trend exhibits a factor-of-1.7 decrease of δDm when the average Dm changes from 1 to 2 mm. Estimation data suggest that this trend diminishes as the spatial scale decreases. Measurement noise and other uncertainties preclude accurate estimations of Dm variability at smaller spatial scales because for many data points estimated variability values are equal to or less than the expected retrieval errors. Even though they are important for retrievals of absolute values of Dm, the details of the drop shape–size relation did not significantly affect estimates of size spatial variability. The polarization cross coupling in simultaneous transmission–simultaneous receiving measurement mode presents another limiting factor for accurate estimations of Dm. This factor, however, was not too severe in estimations of the size variability. There are indications that tuning the differential attenuation correction scheme might balance off some possible cross-coupling ZDR bias if differential phase accumulation is less than approximately 40°.
Comparison of Clinical Results of Anatomic Posterolateral Corner Reconstruction for Posterolateral Rotatory Instability of the Knee With or Without Popliteal Tendon Reconstruction
Authors: Yoon Kyoung Ho , Lee Jung Hwan , Bae Dae Kyung , Song Sang Jun , Chung Kee Yun , Park Yang Woo 
Published: July 2011

Background: It is unknown whether popliteal tendon reconstruction is necessary in anatomic posterolateral corner reconstruction, although the tendon has function in the varus and rotatory stability of the knee joint. Hypothesis: Anatomic reconstructions of the posterolateral corner with the popliteal tendon reconstructed will present better clinical and radiographic results than cases with the popliteal tendon not reconstructed. Study Design: Cohort study; Level of evidence, 3. Methods: The authors retrospectively analyzed 32 cases of anatomic posterolateral corner reconstruction with a minimum 2-year follow-up. There were 17 cases of anatomic reconstruction with popliteal tendon reconstruction and 15 cases without popliteal tendon reconstruction. The authors compared preoperative and postoperative range of motion, varus instability by varus stress test, lateral joint opening on varus stress radiographs, posterolateral rotatory instability by dial test, Tegner activity score, Lysholm score, and International Knee Documentation Committee (IKDC) subjective knee evaluation form and knee examination form between the 2 groups. They also compared posterior translation on posterior stress radiographs in cases with posterior cruciate ligament reconstruction. Results: There was no difference in range of motion, varus stress test, dial test, Tegner score, Lysholm score, or the score by IKDC subjective knee evaluation form. The side-to-side difference in lateral joint opening on the varus stress radiographs significantly improved after anatomic reconstruction in both groups ( P < .001, P = .001), but there was no preoperative or postoperative differences between the groups. No difference was found in the grade distribution on the IKDC examination form. In the cases with posterior cruciate ligament reconstruction, there was also no difference in posterior translation between the groups on posterior stress radiographs at the last follow-up. Conclusion: No effect of popliteal tendon reconstruction was found in anatomic posterolateral corner reconstruction on the stability and clinical results.
Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease
Authors: Kawase Shigeo , Hattori Noboru , Ishikawa Nobuhisa , Horimasu Yasushi , Fujitaka Kazunori , Furonaka Osamu , Isobe Takeshi , Miyoshi Seigo , Hamada Hironobu , Yamane Takashi , Yokoyama Akihito , Kohno Nobuoki 
Published: July 2011

Abstract

Background
A high incidence of interstitial lung disease (ILD) has been reported in patients with advanced non-small cell lung cancer (NSCLC) treated with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), particularly in Japanese populations. A previous report from our laboratory demonstrated that KL-6 was a useful serum biomarker to assess the severity of drug-induced pneumonitis. Based on these observations, this study was conducted to evaluate the risk factors of EGFR-TKIs induced ILD and the usefulness of monitoring serum KL-6 levels in patients who developed EGFR-TKIs induced ILD in a large multi-institutional setting.

Methods
We retrospectively reviewed clinical records and radiographies of 341 patients with advanced NSCLCs who were treated with EGFR-TKIs, and analyzed risk factors for the development of EGFR-TKIs induced ILD. Changes of circulating levels of KL-6 were also evaluated in the patients who developed EGFR-TKIs induced ILD.

Results
Among the 341 patients included in this study, 20 (5.9%) developed EGFR-TKIs induced ILD, and 9 (2.6%) died from ILD. Univariate analyses revealed that only preexisting pulmonary fibrosis was a significant risk factor for the development of EGFR-TKIs induced ILD (p = 0.003). Absolute levels of circulating KL-6 at neither baseline nor the onset of ILD could discriminate between life-threatening and non-life threatening EGFR-TKIs induced ILDs. However, we found that the ratios of serum KL-6 levels just after the onset of EGFR-TKIs induced ILD to those at baseline could quite precisely distinguish survivors from non-survivors (p = 0.006) as well as acute interstitial pneumonia (AIP) pattern from non-AIP pattern (p = 0.005).

Conclusions
The results of this study strongly support the potential of KL-6 as a diagnostic biomarker for life-threatening EGFR-TKIs induced ILD. Monitoring of KL-6 is also useful to evaluate the progression and severity of EGFR-TKIs induced ILD.
Short-term and medium-term clinical outcomes of laparoscopic-assisted and open surgery for colorectal cancer: a single center retrospective case-control study
Authors: Sun Jing , Jiang Tao , Qiu Zhengjun , Cen Gang , Cao Jun , Huang Kejian , Pu Ying , Liang Hong , Huang Renxiang , Chen Shifu 
Published: July 2011

AbstractBackgroundLaparoscopic procedure is a rapid developed technique in colorectal surgery. In this investigation we aim at assessing the diversities of short-term and medium-term clinical outcomes of laparoscopic-assisted versus open surgery for colorectal cancer.MethodsA total number of 519 patients with non-metastatic colorectal cancer were enrolled for this study. The patients underwent either laparoscopic-assisted surgery (LAP) (n = 254) or open surgery (OP) (n = 265). Surgical techniques, perioperative managements and clinical follow-ups were standardized. Short-term perioperative data and medium-term recurrence and survival were compared and analyzed between the two groups.ResultsThere were no differences in perioperative parameters between the two groups except in regards to a trend of faster recovery in laparoscopic procedures. There was no statistically significant difference in postoperative complications, reoperation rate, or perioperative mortality. Statistically significant differences in a faster return of gastrointestinal function and shorter hospital stay were identified in favor of laparoscopic-assisted resection. In colon and rectal cancer cases separately, the overall survival, cancer-free survival and recurrence rate were similar in two groups. There was also no tendency of significant differences in overall survival, cancer-free survival and recurrence in stage I-II and stage III patients in two cancer categories between the two groups, respectively. pT, lymph node metastasis, and clinical stage were independent predictors of overall death risk, while pT, pN, lymph node metastasis and clinical stage were found to be the independent predictors of recurrence risk in enrolled patients database.ConclusionsLaparoscopic-assisted procedure has more benefits on postoperative recovery, while has the same effects on medium-term recurrence and survival compared with open surgery in the treatment of non-metastatic colorectal cancer.
Targeting renal cell carcinoma with NVP-BEZ235, a dual PI3K/mTOR inhibitor, in combination with sorafenib
Authors: Roulin Didier , Waselle Laurent , Dormond-Meuwly Anne , Dufour Marc , Demartines Nicolas , Dormond Olivier 
Published: July 2011

Abstract

Background
Targeted therapies for metastatic renal cell carcinoma (RCC), including mammalian target of rapamycin (mTOR) inhibitors and small-molecule multikinase inhibitors, have produced clinical effects. However, most patients acquire resistance over time. Thus, new therapeutic strategies need to be developed. Here, we evaluated the effect of the dual PI3K/mTOR inhibitor NVP-BEZ235, in combination with the multikinase inhibitor sorafenib on renal cancer cell proliferation and survival in vitro as well as on tumor growth in vivo.

Methods
The renal carcinoma cell lines 786-0 and Caki-1 were treated with NVP-BEZ235 or sorafenib, either alone or in combination. Tumor cell proliferation and apoptosis were investigated in vitro. The anticancer efficacy of NVP-BEZ235 alone, or in combination with sorafenib, was also evaluated on RCC xenografts in nude mice.

Results
Treatment of 786-0 and Caki-1 cells with NVP-BEZ235 or sorafenib resulted in reduced tumor cell proliferation and increased tumor cell apoptosis in vitro. The combination of NVP-BEZ235 and sorafenib was more effective than each compound alone. Similarly, in vivo, NVP-BEZ235 or sorafenib reduced the growth of xenografts generated from 786-0 or Caki-1 cells. The antitumor efficacy of NVP-BEZ235 in combination with sorafenib was superior to NVP-BEZ235 or sorafenib alone.

Conclusions
Our findings indicate that the simultaneous use of NVP-BEZ235 and sorafenib has greater antitumor benefit compared to either drug alone and thus provides a treatment strategy in RCC.
ZEB1 limits adenoviral infectability by transcriptionally repressing the Coxsackie virus and Adenovirus Receptor
Authors: Lacher Markus D , Shiina Marisa , Chang Peter , Keller Debora , Tiirikainen Maarit I , Korn W Michael 
Published: July 2011

Abstract

Background
We have previously reported that RAS-MEK (Cancer Res. 2003 May 1;63(9):2088-95) and TGF-β (Cancer Res. 2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake. In the case of TGF-β, down-regulation of CAR occurred in context of epithelial-to-mesenchymal transition (EMT), a process associated with transcriptional repression of E-cadherin by, for instance, the E2 box-binding factors Snail, Slug, SIP1 or ZEB1. While EMT is crucial in embryonic development, it has been proposed to contribute to the formation of invasive and metastatic carcinomas by reducing cell-cell contacts and increasing cell migration.

Results
Here, we show that ZEB1 represses CAR expression in both PANC-1 (pancreatic) and MDA-MB-231 (breast) human cancer cells. We demonstrate that ZEB1 physically associates with at least one of two closely spaced and conserved E2 boxes within the minimal CAR promoter here defined as genomic region -291 to -1 relative to the translational start ATG. In agreement with ZEB1's established role as a negative regulator of the epithelial phenotype, silencing its expression in MDA-MB-231 cells induced a partial Mesenchymal-to-Epithelial Transition (MET) characterized by increased levels of E-cadherin and CAR, and decreased expression of fibronectin. Conversely, knockdown of ZEB1 in PANC-1 cells antagonized both the TGF-β-induced down-regulation of E-cadherin and CAR and the reduction of adenovirus uptake. Interestingly, even though ZEB1 clearly contributes to the TGF-β-induced mesenchymal phenotype of PANC-1 cells, TGF-β did not seem to affect ZEB1's protein levels or subcellular localization. These findings suggest that TGF-β may inhibit CAR expression by regulating factor(s) that cooperate with ZEB1 to repress the CAR promoter, rather than by regulating ZEB1 expression levels. In addition to the negative E2 box-mediated regulation the minimal CAR promoter is positively regulated through conserved ETS and CRE elements.

Conclusions
This report provides evidence that inhibition of ZEB1 may improve adenovirus uptake of cancer cells that have undergone EMT and for which ZEB1 is necessary to maintain the mesenchymal phenotype. Targeting of ZEB1 may reverse some aspects of EMT including the down-regulation of CAR.
High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal
Authors: Kilbride Seán M , Gluchowska Sonia A , Telford Jayne E , O'Sullivan Catherine , Davey Gavin P 
Published: July 2011

Abstract

Background
The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington's disease and Alzheimer's disease, respectively, and are associated with excitotoxic cell death in these disorders. In this study, we investigated the control that complexes III and complex IV exert on glutamate release from the isolated nerve terminal.

Results
Inhibition of complex III activity by 60-90% was necessary for a major increase in the rate of Ca2+-independent glutamate release to occur from isolated nerve terminals (synaptosomes) depolarized with 4-aminopyridine or KCl. Similarly, an 85-90% inhibition of complex IV activity was required before a major increase in the rate of Ca2+-independent glutamate release from depolarized synaptosomes was observed. Inhibition of complex III and IV activities by ~ 60% and above was required before rates of glutamate efflux from polarized synaptosomes were increased.

Conclusions
These results suggest that nerve terminal mitochondria possess high reserves of complex III and IV activity and that high inhibition thresholds must be reached before excess glutamate is released from the nerve terminal. The implications of the results in the context of the relationship between electron transport chain enzyme deficiencies and excitotoxicity in neurodegenerative disorders are discussed.
Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study
Authors: Darmon Michael , Vincent Francois , Dellamonica Jean , Schortgen Frederique , Gonzalez Frederic , Das Vincent , Zeni Fabrice , Brochard Laurent , Bernardin Gilles , Cohen Yves , Schlemmer Benoit 
Published: July 2011

Abstract
Introduction
Several factors, including diuretic use and sepsis, interfere with the fractional excretion of sodium, which is used to distinguish transient from persistent acute kidney injury (AKI). These factors do not affect the fractional excretion of urea (FeUrea). However, there are conflicting data on the diagnostic accuracy of FeUrea.

Methods
We conducted an observational, prospective, multicenter study at three ICUs in university hospitals. Unselected patients, except those with obstructive AKI, were admitted to the participating ICUs during a six-month period. Transient AKI was defined as AKI caused by renal hypoperfusion and reversal within three days. The results are reported as medians (interquartile ranges).

Results
A total of 203 patients were included. According to our definitions, 67 had no AKI, 54 had transient AKI and 82 had persistent AKI. FeUrea was 39% (28 to 40) in the no-AKI group, 41% (29 to 54) in the transient AKI group and 32% (22 to 51) in the persistent AKI group (P = 0.12). FeUrea was of little help in distinguishing transient AKI from persistent AKI, with the area under the receiver operating characteristic curve being 0.59 (95% confidence interval, 0.49 to 0.70; P = 0.06). Sensitivity was 63% and specificity was 54% with a cutoff of 35%. In the subgroup of patients receiving diuretics, the results were similar.

Conclusions
FeUrea may be of little help in distinguishing transient AKI from persistent AKI in critically ill patients, including those receiving diuretic therapy. Additional studies are needed to evaluate alternative markers or strategies to differentiate transient from persistent AKI.
High efficiency in human muscle: an anomaly and an opportunity?
Authors: Nelson Frank E. , Ortega Justus D. , Jubrias Sharon A. , Conley Kevin E. , Kushmerick Martin J. 
Published: July 2011

SummaryCan human muscle be highly efficient in vivo? Animal muscles typically show contraction-coupling efficiencies &lt;50% in vitro but a recent study reports that the human first dorsal interosseous (FDI) muscle of the hand has an efficiency value in vivo of 68%. We examine two key factors that could account for this apparently high efficiency value: (1) transfer of cross-bridge work into mechanical work and (2) the use of elastic energy to do external work. Our analysis supports a high contractile efficiency reflective of nearly complete transfer of muscular to mechanical work with no contribution by recycling of elastic energy to mechanical work. Our survey of reported contraction-coupling efficiency values puts the FDI value higher than typical values found in small animals in vitro but within the range of values for human muscle in vivo. These high efficiency values support recent studies that suggest lower Ca2+ cycling costs in working contractions and a decline in cost during repeated contractions. In the end, our analysis indicates that the FDI muscle may be exceptional in having an efficiency value on the higher end of that reported for human muscle. Thus, the FDI muscle may be an exception both in contraction-coupling efficiency and in Ca2+ cycling costs, which makes it an ideal muscle model system offering prime conditions for studying the energetics of muscle contraction in vivo.
High phosphate uptake requirements of the scleractinian coral Stylophora pistillata
Authors: Godinot Claire , Grover Renaud , Allemand Denis , Ferrier-Pagès Christine 
Published: July 2011

SUMMARY
Several untested aspects of the regulation of inorganic nutrient uptake were examined using nutrient depletion experiments with the symbiotic coral Stylophora pistillata. The total inhibition of phosphate uptake in artificial seawater lacking sodium indicates the involvement of a sodium/phosphate symporter for the uptake of phosphate across host membranes. Addition of ammonium or nitrate (up to 6.0 μmol l–1) did not enhance saturated phosphate uptake rates, thus indicating that corals, or their symbiotic algae, were not, or not sufficiently, nitrogen limited to modify their phosphate needs. Conversely, the saturated uptake rate of ammonium increased by 2.5-fold in the presence of 3.0 μmol l–1 of phosphate, thus indicating that the corals or their symbionts were lacking intracellular phosphate to take advantage of the inorganic nitrogen compounds dissolved in their surrounding medium. Overall, these results highlight some greater limitation in phosphate rather than in nitrogen. Finally, the rate of phosphate uptake decreased with particulate feeding of the host (organic phosphate source). Indeed, corals that were fed 1 and 3 days before the uptake experiment took up phosphate 42 and 19% slower, respectively, than corals that were fed 21 days before. This result provides additional evidence of phosphate limitation in S. pistillata. This study therefore brings new insights into the relationships between nutrients and symbiotic corals, and may provide a rapid and effective tool to investigate which nutrient is the most limiting for coral metabolism.
4kast-Pro™ - A Novel Tool for Trend-based and Multi-stream Production Forecasting
Authors: Ibeh C. , Adeoye A. , Ibrahim J , Reynolds K. 
Published: July 2011

Abstract
The application of appropriate tools and processes is necessary to ensure reliable and accurate forecasts of hydrocarbon reserves that will enable more informed capital management decisions on projects. This becomes even more critical considering the tight budget environment which most operators face in the oil and gas industry.
Sustaining oil production in brown fields comes with a myriad of challenges because the once blocky and apparently homogeneous sands are now compartmentalized due to differential depletion, water influx / poor waterflood performance and the emergent effects of erstwhile salient features like small channels, sub-seismic faults, baffles and heterogeneities. These truths get revealed with time as we know more about the reservoirs / fields through: state-of-the-art seismic data acquisition and/or reprocessing, formation evaluation and production data mapping. This information also helps to finetune our simulation models.
The implication is that viable new drill opportunities have now become more difficult to identify and adequately plan because the targets are no longer as evident or "stacked" one on top of another. Due to the prevailing high cost environment, a new drill opportunity today more than ever before will require multiple targets in order to pass the economic hurdle.
Accurately forecasting these multiple streams is critical to meeting the overall project objective. The 4kast-Pro™ software has been built to provide a structured approach to developing production forecasts which is critical to achieving world-class reservoir performance and return on investment.
Evaluation of dehiscences using cone beam computed tomography
Authors: Ising Nicholas , Kim Ki Beom , Araujo Eustaquio , Buschang Peter 
Published: July 2011

Abstract

Objective:
To validate the use of three-dimensional (3-D) surface rendering (SR) images to quantify the height of alveolar dehiscences.

Materials and Methods:
Twenty-four dehiscences were created on 9 incisors, 9 canines, and 6 premolars on 4 cadaver skulls. i-CAT cone beam computed tomography scans (CBCTs) were taken of each skull at .2 mm voxel size. Each dehiscence was quantified by 21 orthodontic residents using 3-D SR. The principal investigator (PI) also quantified each dehiscence using the 2-D multiplanar (MP) image and the 3-D SR image.

Results:
Results of this study showed an average method error of the residents as a group to be 0.57 mm with an intraclass correlation (ICC) of 0.77%. Residents' method error ranged from 0.45 mm to 1.32 mm, and the ICC ranged from 0.201% to 0.857%. Systematic error was low at −0.01 mm for the direct measurement compared with the residents' average 3-D SR at 1365 density value (DV) measurement. The 3-D SR at 1365 DV images were compared with the MP and 3-D SR images at 1200 DV, and no significant differences in measurements and low systematic error were noted. The method error of the PI was 0.45 mm, 0.45 mm, and 0.41 mm for 3-D SR at 1365 DV, 3-D SR at 1200 DV, and 2-D MP, respectively.

Conclusions:
3-D SR and 2D MRP can be used to measure dehiscences of the periodontium with similar levels of accuracy.