bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Call To Action: Black Male Educators! It is Your Time: A Mixed Methods Study on Beginning Black Male Educator’s Experiences in Teacher Preparation Programs, Preparedness, and Opportunities for Retention
Authors: Jackson Leonard , Dicks Towan 
Published: June 2024

Abstract

The purpose of this sequential explanatory mixed method study was to understand the beginning Black male teachers’ (BMT) preparedness, perceptions of the pre-service experience, and give opportunities for retention for Teacher Education Programs. The significance of this study was to fill the significant void in research, understand the preparedness of African American male students through a teacher preparation program, and to understand the beginning teachers' preparedness and the ability to fully execute their roles as a classroom teacher. This study used a sequential explanatory mixed method design which included survey collection and in-depth interviews to explore the critical lived experiences of the participants. The quantitative data was collected from 104 Black Male Educators. The data content validity was checked with the Pearson r 2-tailed correlation. Qualitative data was collected from the interviews of five (5) beginning Black Male Educators. The researcher interpreted the statements from the interviews and conducted an analysis revealing codes and themes. Four major themes emerged from the data, which were: (1) Self-Efficacy, (2) Teacher Preparation Programs are effective, (3) Family Dynamics and Socioeconomics play a critical role, and (4) Representation of Black Men Matters. The conclusions specified that Teacher Preparation Programs are effective in the trajectory of Black male educators. However, the findings revealed that the further Black male educators move away, in time, from their programs, the less they it as a factor in their effectiveness. The findings revealed that there was a significant relationship between the beginning African American male educator and their preparedness by their Teacher Preparation Program. The findings additionally show that the further the beginning Black Male Educator moves away from their program, the least impact it has on their level of preparedness to fulfill their role. The study revealed several recommendations for practice and research that would improve the lived experiences of Black male educators including mentorships in Teacher Preparation Programs, Partnerships amongst Teacher Preparation Programs and School districts, and Empowerment and Continual Support of Black Male Educators. The participants responses provide a framework for Teacher Preparation Program stakeholders, current administrators, and district-level staff recruiters to follow.
Artificial intelligence-based morphologic classification and molecular characterization of neuroblastic tumors from digital histopathology
Authors: Applebaum Mark , Ramesh Siddhi , Dyer Emma , Pomaville Monica , Doytcheva Kristina , Dolezal James , Kochanny Sara , Terhaar Rachel , Mehrhoff Casey , Patel Kritika , Brewer Jacob , Kusswurm Benjamin , Naranjo Arlene , Shimada Hiroyuki , Sokol Elizabeth , Cohn Susan , George Rani , Pearson Alexander 
Published: June 2024

Abstract

A deep learning model using attention-based multiple instance learning (aMIL) and self-supervised learning (SSL) was developed to perform pathologic classification of neuroblastic tumors and assess MYCN-amplification status using H&E-stained whole slide digital images. The model demonstrated strong performance in identifying diagnostic category, grade, mitosis-karyorrhexis index (MKI), and MYCN-amplification on an external test dataset. This AI-based approach establishes a valuable tool for automating diagnosis and precise classification of neuroblastoma tumors.
Optimization of DMAs design and cooperative pressure reducing valves and pumping stations to achieve leakage control and energy saving strategy of water distribution networks
Authors: Li HongYan , Shi Wentao , Chang Zifeng , Zhang Feng , Cui Jianguo , Lu Xulong , Mao Libo 
Published: June 2024

Abstract

Leakage and energy consumption in urban water distribution networks (WDNs) have been receiving increasing attention, and pressure management based on district metered areas (DMAs) can effectively control leakage and save energy. In this paper, a new design method for establishing DMAs and carrying out pressure management is proposed. First, the combination of the non-dominated sorting genetic algorithm (NSGA-III) and spectral clustering algorithms, considering the partition cost, operation and management difficulty, post-partition water quality safety, and network water supply capacity factors, identifies the best DMA layouts and the corresponding boundary pipes with the help of multicriteria decision making (MCDM) methods. Second, the non-dominated sorting genetic algorithm (NSGA-II) is used to solve the optimal arrangement model of valves and flow meters on the boundary pipes, and the optimal arrangement is determined based on the equipment cost, water quality safety, and leakage control effect after partition. Finally, pressure reducing valves (PRVs) are installed at the inlet of the DMAs, and a genetic algorithm is used to solve the joint scheduling optimization model of the PRVs and pump station in WDNs to determine the optimal scheduling strategy for the PRVs and the fixed and variable speed pumps for leakage control and energy saving. The proposed method is applied to the SH town network. Results reveal that the method can establish DMAs considering multiple objectives. Furthermore, pressure management in DMAs can not only significantly reduce leakage and energy consumption of pumping stations but also improve the water quality of networks. Therefore, this method can provide a reference for water utilities in establishing DMAs and carrying out pressure management in WDNs in the future.
Psychological Difficulties and the Needs for Counseling Services in High School Students
Authors: Le Cong Minh , Huynh Son-Van , Nguyen Vu Hoang Anh , Le Vy Truc , Luu-Thi Huyen-Trang , Tran-Chi Vinh-Long 
Published: June 2024

Abstract

Adolescents experience numerous changes, both psychologically and physically, and they are also the age group with a high prevalence of mental problems that need counseling help. The study aims to assess the demand for psychological services among adolescents, a vital concern that must be discussed. A total of 672 high school students were collected in Thu Duc City, Vietnam. The results showed that there was a statistically significant difference between grades 10–12 in student’s difficulties (DS), need for psychological support (NPS), and request for psychology services (RPS). Additionally, there was a statistically significant difference in student performance for DS. The findings also implied that RPS was predicted by a DS, NPS, and factors affecting the need to use psychological services (FA), in which NPS and DS were mediators in the relationship between FA and RPS. The study significantly contributes to research practices and the theoretical framework that the parliament and the government use to make counselors mandatory in schools. Meanwhile, the study suggested that school counselors, educators, and teachers must appropriately evaluate students' counseling needs and psychological difficulties; this is essential to providing support and interventions when students deal with challenges promptly.
Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition criteria in nutritional diagnosis of hepatocellular carcinoma
Authors: Li Juan , Jiang Minjie , Hua Xin , Xu Hongxia , Wu Muchen , Wu Jing , Liu Songtao , Shi Hanping , Meng Qinghua 
Published: June 2024

Abstract

Background
The Global Leadership Initiative on Malnutrition criteria (GLIM) was established to build a global consensus on the diagnostic criteria for malnutrition. The study aimed to assess the prevalence of the malnutrition diagnosed by GLIM criteria for patients with hepatocellular carcinoma (HCC), and to determine the role of the reduced muscle mass defined by CT scans in the GLIM criteria.
Methods
This cohort research was conducted on adult patients with HCC. The risk of malnutrition was screened by Nutritional Risk Screening 2002 (NRS-2002), and malnutrition was diagnosed by GLIM criteria. The third lumbar vertebrae (L3-SMI) were used to represent the muscle mass in GLIM criteria. The variables associated with overall mortality were assessed by multivariate Cox regression analyses.
Results
The prevalence of malnutrition defined by GLIM criteria was 49.7% (179/360) in patients with HCC. If reduced muscle mass was not included in GLIM criteria, the prevalence of malnutrition was 31.7% (114/360). GLIM-defined malnutrition (HR=1.979, 95%CI 1.019-3.841, P=0.044) was independently associated with overall mortality in patients with HCC. However, the GLIM-defined malnutrition (without muscle mass) was not associated with overall mortality (HR=0.863, 95%CI 0.399-1.867, P=0.709).
Conclusions
Skeletal muscle mass is an important part of GLIM criteria in patients with HCC. The malnutrition is common in patients with HCC, and malnourishment is associated with higher overall mortality. GLIM criteria is recommended to assess the nutritional status of hospitalized patients with HCC, which is recommended and can be used as the basis for nutritional interventions.
A bibliometric analysis of HIV-1 drug-resistant minority variants from 1994 to 2022
Authors: Yan Chang , Yu Fengting , Li Mengying , Yang Xiaojie , Sun Rui , Liang Xuelei , Lao Xiaojie , Zhang Hanxi , Lv Wenhao , Hu Ying , Lai Yuan , Ding Yi , Zhang Fujie 
Published: June 2024

Abstract

Background
The rapid initiation of antiretroviral therapy has become an international trend, necessitating lifelong medication for all HIV patients. Sanger sequencing, as the gold standard for clinically detecting HIV drug resistance, often fails to detect mutations comprising less than 20% of the total viral population. With the advancement of detection technologies, HIV-1 DRMinVs have garnered increasing attention. However, there are few studies exploring the hotspots and trends in this field. Fortunately, bibliometrics, a novel approach to literature analysis, can fill this gap effectively.
Methods
Publications related to HIV-1 DRMinVs from 1994 to 2022 were searched on the WoSCC database. Visual knowledge maps and bibliometric analyses were generated using VOSviewers, CiteSpace, and the R package "bibliometrix."
Results
In total, 853 publications concerning HIV-1 DRMinVs were identified from 1994 to 2022, demonstrating a steady increase in publication output over the years. The United States, France, and the United Kingdom significantly lead in publication output. The main research institutions are Harvard University, University of Pittsburgh, Stanford University and National Cancer Institute. The Journal of Antimicrobial Chemotherapy holds the highest prominence among journals in this domain, while the Journal of Virology emerges as the most frequently co-cited journal. A total of 5687 authors have contributed to these publications. Among them, Vincent Calvez, Francesca Ceccherini-Silberstein, and John M. Coffin emerge as the most prolific authors, having published the highest number of articles. Additionally, Metzner, KJ emerges as the most frequently co-cited author. The main trends include the origins, molecular epidemiology, detection methods of DRMinVs, their impact on virological outcomes in drug-naïve patients, and novel research focuses primarily revolve around keywords such as "NGS," "ART," "VF," and "GRT."
Conclusions
The use of medication inevitably leads to drug resistance. For HIV-1 DRMinVs, the emergence of NGS has addressed the issue of missed detections by Sanger sequencing. However, its high cost and stringent laboratory requirements have limited its widespread application. Therefore, future research should focus on improving and refining NGS to make it simpler and more affordable, and explore when it can serve as a supplement to Sanger sequencing.
Abdominal LIPUS stimulation prevents cognitive decline in hind limb unloaded mice by regulating gut microbiota
Authors: zheng Yumei , Yu Yanan , Chen Mengyao , zhang Huiyuan , Wang Wanzhao , Fan Xiushan , Sun Lijun , Tang Liang , Ta Dean 
Published: June 2024

Abstract

Weightlessness usually causes disruption of the gut microbiota and impairs cognitive function. There is a close connection between gut microbiota and neurological diseases. Low intensity pulsed ultrasound (LIPUS) has a beneficial effect on reducing intestinal inflammation. So we wondered if abdominal LIPUS stimulation can have a positive impact on weightlessness induced cognitive decline by reducing intestinal dysfunction. The findings revealed that the hind limb unloaded mice exhibited evident disruption in intestinal structure and gut microbial homeostasis, along with impairment in their learning and memory capabilities. However, 4-week abdominal LIPUS treatment improved intestinal function in hind limb unloaded mice, characterized by upregulation of tight junction proteins ZO-1 and Occludin expression in the colon, increased diversity and abundance of intestinal microbiota, decreased serum lipopolysaccharide (LPS), and increased short chain fatty acids in colon contents. The hind limb unloaded mice treated with LIPUS exhibited heightened activity levels, improved exploratory tendencies, and significantly enhanced learning and memory faculties, and elevated expression of neuroadaptation-related proteins such as PSD95, GAP43, P-CREB, BDNF, and its receptor TRKB in the hippocampus. Furthermore, the hind limb unloaded mice receiving fecal transplants from the mice whose abdomens were irradiated with LIPUS displayed enhanced cognitive abilities and improved intestinal structure, akin to the outcomes observed in hind limb unloaded mice who received LIPUS abdominal treatment directly. The above results indicate that LIPUS enhances intestinal structure and microbiota, which helps alleviate cognitive impairment caused by weightlessness. LIPUS could be a potential strategy to simultaneously improve gut dysfunction and cognitive decline in astronauts or bedridden patients.
Lipid remodeling in serum and correlation with stroke in patients with leukoaraiosis
Authors: Lin Feng , Song Yige , Cao Hongi , Song Wangting , Liao Fengye , Deng Yanping , Wei Qinyu , Hong Weimin , Yao Guifeng , Sze Fat Tin Agassi , Ding Chunguang , Chen Xianyang 
Published: June 2024

Abstract

Background
Despite the identification of many hub lipids for stroke, the underlying pathophysiology of stroke in elderly patients with leukoaraiosis (LA) remains poorly understood, which is important for the administration of antithrombotic therapy for LA patients. This study aims to illuminate the preliminary lipid metabolic process associated with stroke in LA patients (LS).
Methods
The study cohort consisted of 215 individuals undergoing magnetic resonance imaging(MRI), from which a subset 13 patients with stroke matched with a control group, and 48 LS patients matched with 40 LA patients were selected for further investigation after exclusion. Serum lipidome was profiled by UPLC-TOF. OPLS-DA was used for classification and identifying differential metabolites. Customizing structural equation (CSE) model was applied to assess the pathway weight of novel metabolites in stroke incidence. Linear regression and matrix correlation were used to investigate the relationships between differentiated metabolites and outcomes.
Results
Using lipid profiling and multivariate statistical analysis, we screened 168 different compounds between LA and LS. Based on the enrichment and Sankey diagram of pathway, 52 lipid molecules were regarded as differential metabolites associated with glycerolipid, glycerophospholipid, and sphingolipid metabolism. After CSE weighted the pathway node molecules, we finally identified 11 key metabolites achieving a prediction, in which DG(14:0/22:4) (OR = 5.33) and Cer(d18:1/24:1) (OR = 21.44) were significant risk factors for LS. All 11 metabolites exhibited correlations with the outcome (LS incidence), with particularly heightened metabolic disruption in the presence of high blood pressure. We conducted linear regression analysis and found changes in FA16:1; O, DG(12:0/17:2) and DG(14:0/22:4) out of 11 metabolites correlated with Fazekas scores between CK and LS group. Similarly, compared with LA group, DG(14:0/22:4) (OR = 5.33, p = 0.02) and Cer(d18:1/24:1) (OR = 21.44, p = 0.068) are risk factors for LS. Especially, Cer(d18:1/24:1) and PI(22:1/20:1) were significantly associated with the LS incidence.
Conclusion
This study identified 11 metabolites as key metabolites for stroke incidence in LA patients, including subgroups divided by Fazekas scores. This study provides novel insights into lipid metabolic process from LA to LS, in which the lipid disturbance in glycolipids and glycerophospholipids, as well as the regulatory role of Cer(18:1/24:1), which are valuable for further studies of LS.
An iridium(III) complex based luminogenic probe for high-throughput screening of H2S donors in living cells
Authors: Wu Ke-Jia , Sun Wen , Sun Jian-Min , Lu Chang , Li Yan , Sun Ning , Leung Chung-Hang , Wu Chun 
Published: June 2024

Abstract

The scarcity of suitable high-throughput screening technology for H2S donors has hampered the discovery of H2S donors. In this study, a long-lived cyclometalated iridium complex was rationally designed as a mitochondria-targeted H2S probe to monitor the real-time dynamic change of H2S. By using time-resolved emission spectroscopy (TRES) technique, an anti-interference high-throughput screening system was developed to monitor H2S in living cells with decreased false negative results. As a proof-of-concept, three natural products were identified as potential H2S donors from a natural product library using the developed TRES probe. Notably, the discovery of allicin and diallyl trisulfide demonstrated the feasibility of this screening platform, while garlic derived allyl methyl sulfide was explored as a H2S donor candidate. The results were further validated by a commercial assay. We anticipate this high-throughput platform could facilitate the discovery of H2S donors by discriminating the endogenous interfering fluorescence from biological system.
Case Report: Prolonged Clinical Benefit of ESG401, a Novel Trophoblast Cell-Surface Antigen 2 (Trop-2) Antibody-Drug Conjugate (ADC), in a Patient with Endocrine- Refractory Hormone Receptor-Positive, HER-2 Negative Metastatic Breast Cancer
Authors: Zhao Jing , Huang Fengbo , Xu Xia , Zhang Yan , Xing Xiaoyan , Huang Jian , Qiu Fuming 
Published: June 2024

Abstract

Breast cancer (BC) remains a leading cause of cancer-related mortality in women, with hormone receptor-positive (HR+) tumors accounting for a significant proportion of cases. Despite advancements in endocrine therapy (ET), resistance remains a challenge in metastatic settings. The use of cyclin-dependent kinases 4/6 (CDK4/6) inhibitors in combination with endocrine therapy has notably improved survival. In China, when patients develop resistance to CDK4/6 inhibitors (CDK4/6i) or face financial constraints that prevent their use, chemotherapy becomes the standard treatment approach. This highlights an urgent need for effective treatments following CDK4/6i therapy. ESG401 is a novel Trop2-directed antibody-drug conjugate (ADC) with promising preclinical and early clinical efficacy and safety data. We report a case of a 61-year-old female with HR + HER2- metastatic breast cancer (MBC) who developed resistance to fulvestrant and subsequent chemotherapy but achieved a durable partial response (PR) lasting more than 22.5 months following ESG401 treatment. This case underscores the potential role of Trop2-directed ADCs, such as ESG401, in overcoming endocrine resistance and providing meaningful clinical benefit in heavily pretreated patients with HR+/HER2- MBC. Furthermore, the patient's exceptionally long clinical benefit distinguishes her from other patients receiving ESG401 treatment. Further exploration of the use of ESG401 in HR + HER2- MBC patients, as well as a deeper understanding of the characteristics of patients that may impact sustained efficacy, in expanded clinical trials is warranted.
Study on the control of mechanical and electrical properties of 3D printed BTO/PDMS flexible porous composites
Authors: Hao YiChen , Wang Jun , Wang Qian , Chen Jimin , Zeng Yong 
Published: June 2024

Abstract

Flexible piezoelectric functional composite materials have the advantages of strong plasticity and good surface adhesion, and show great potential in smart wearable devices, electronic skin and other applications. However, due to the complexity of traditional preparation process, high molding cost and poor air permeability, its further development is limited. Direct ink writing (DIW) 3D printing technology is a rapid prototyping technology, with higher flexibility, faster manufacturing speed and lower manufacturing costs, is widely used in metal, ceramic and composite material molding. In this work, a slurry system with polydimethylsiloxane (PDMS) as binder and Barium titanate (BTO) ceramic powder as piezoelectric filler was developed, the printing work of flexible porous BTO/PDMS composite material was completed, and DIW dual-nozzle printing technology was developed. The integrated flexible porous electrode - piezoelectric - electrode functional gradient structure composite was realized. The results show that the BTO/PDMS ink has the characteristics of shear thinning. When the nozzle diameter is 0.5 mm, the printing speed is 650 mm/min, and the BTO mass fraction is 80%, the flexible porous piezoelectric composite with high precision and complex structure is printed. By phase analysis of BTO/PDMS, it is found that the sample has the characteristic peak of BTO. The microstructure analysis shows that the surface of the sample has good structural fidelity and there are a few island-like pores in the interior. The mechanical test shows that the maximum tensile strength of the sample is 1.33 MPa, the elastic modulus is 1.72 MPa, the longitudinal piezoelectric coefficient d33 is 4.37 Pc/N, and the open circuit voltage VOC is 3.17 V. This work demonstrates a highly attractive method for forming flexible piezoelectric materials with “electrode-piezoelectric-electrode” structures, which, due to its simple operation, time and manufacturing cost savings, proposes solutions to key problems in current 3D ceramic manufacturing technologies.