bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initial investigation on ultrasound-guided percutaneous biopsy of lesions in the first hepatic hilum with fusion of ultrasound and multimodal imaging cognitive guidance
Authors: Zeng Xian-Tao , Liang Xia , Hong Zhi-Liang , Chen Sheng , Yang Jian-Chuan , Lin Yu-cheng , Wu Song-Song 
Published: April 2024

PurposeThis study aims to evaluate the efficacy and safety of ultrasound-guided percutaneous biopsy of the first hepatic hilum lesion, and examine its clinical value of diagnosis and treatment.MethodsWe conducted a retrospective study on patients diagnosed with the first hepatic hilum lesions at Fujian Provincial Hospital between February 2015 and October 2022. We selected patients who had lesions in the first hepatic hilum(including a 2cm surrounding area of the left/right hepatic ducts and upper-middle segment of the common bile duct) and the liver periphery(in the peripheral area of the liver, outside of the above-mentioned first hepatic porta region). These patients underwent percutaneous ultrasound-guided core needle biopsy (PUS-CNB) with cognitive fusion guidance using CT, MRI, or PET-CT. We compared the safety and efficacy of PUS-CNB in the first hepatic hilum and the liver periphery to explore the value of PUS-CNB in optimizing the clinical treatment of the first hepatic hilum lesions.ResultsThe studied includes 38 cases of the first hepatic hilum cases (18 females; 20 males), 23 presented with mass-forming tumors while the remaining 15 exhibited diffuse infiltrative tumors, with an average diameter of 4.65± 2.51 cm. The percutaneous biopsy procedure, conducted under ultrasound guidance, had an average operation time of 14.55 ± 2.73 minutes, and resulted in a postoperative bleeding volume of approximately 10.79 ± 2.79 ml. The diagnostic success rate was noted to be as high as 92.11% among the participants who underwent percutaneous biopsy of the first hepatic hilum. Procedural complications, such as bleeding, bile leakage, intestinal perforation, infection or needle tract seeding, did not occur during or after the biopsy procedure. Affected by biopsy results, 5 altered their clinical treatment plans accordingly, 24patients received non-surgical treatment, 9 underwent surgical treatment, 5 underwent radiofrequency ablation for the lesions. The study comprised a total of 112 cases for percutaneous biopsy of the liver periphery. The safety and effectiveness of the two biopsy techniques were comparable, with diagnostic success rates of 92.11% VS. 94.34%, respectively (p = 0.61).ConclusionCognitive fusion of ultrasound and multi-modal imaging for the first hepatic hilum lesion puncture biopsy is a safe and effective diagnostic procedure, with better diagnostic rate, may improve clinical value of diagnosis and treatment of various diseases.
Prevalence and plasma exosome-derive microRNA diagnostic biomarker screening of adolescent idiopathic scoliosis in Yunnan Province, China
Authors: Yuan Ping , Wang Zhi-Hua , Jiang Hong , Wang Yang-Hao , Yang Jian-Yi , Li Lu-Ming , Wang Wen-Tong , Chen Jing , Li Deng-Hui , Long Sheng-Yu , Zhang Wan , He Fei , Wang Wei-Zhou 
Published: April 2024

BackgroundIdiopathic scoliosis significantly affects the physical and mental health of children and adolescents, with varying prevalence rates in different regions. The occurrence of idiopathic scoliosis is associated with genetic regulation and biochemical factors, but the changes in exosome-derived miRNA profiles among idiopathic scoliosis patients remain unclear. This study aimed to determine the prevalence of idiopathic scoliosis in Yunnan Province, China, and identify key exosome-derived miRNAs in idiopathic scoliosis through a cohort study.MethodsFrom January 2018 to December 2020, a cross-sectional study on idiopathic scoliosis in children and adolescents was conducted in Yunnan Province. A total of 84,460 students from 13 cities and counties in Yunnan Province participated in a scoliosis screening program, with ages ranging from 7 to 19 years. After confirmation through screening and imaging results, patients with severe idiopathic scoliosis and normal control individuals were selected using propensity matching. Subsequently, plasma exosome-derived miRNA sequencing and RT-qPCR validation were performed separately. Based on the validation results, diagnostic performance analysis and target gene prediction were conducted for differential plasma exosome-derived miRNAs.ResultsThe overall prevalence of idiopathic scoliosis in children and adolescents in Yunnan Province was 1.10%, with a prevalence of 0.87% in males and 1.32% in females. The peak prevalence was observed at age 13. Among patients diagnosed with idiopathic scoliosis, approximately 12.8% had severe cases, and there were more cases of double curvature than of single curvature, with thoracolumbar curvature being the most common in the single-curvature group. Sequencing of plasma exosome-derived miRNAs associated with idiopathic scoliosis revealed 56 upregulated and 153 downregulated miRNAs. Further validation analysis confirmed that hsa-miR-27a-5p, hsa-miR-539-5p, and hsa-miR-1246 have potential diagnostic value.ConclusionsWe gained insights into the epidemiological characteristics of idiopathic scoliosis in Yunnan Province and conducted further analysis of plasma exosome-derived miRNA changes in patients with severe idiopathic scoliosis. This study has provided new insights for the prevention and diagnosis of idiopathic scoliosis, paving the way for exploring clinical biomarkers and molecular regulatory mechanisms. However, further validation and elucidation of the detailed biological mechanisms underlying these findings will be required in the future.
Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: aldehyde dehydrogenase 1A1 suppression and ferroptosis induction
Authors: Abu-Serie Marwa M. , Osuka Satoru , Heikal Lamiaa A. , Teleb Mohamed , Barakat Assem , Dudeja Vikas 
Published: April 2024

The development of effective therapy for eradicating glioblastoma stem cells remains a major challenge due to their aggressive growth, chemoresistance and radioresistance which are mainly conferred by aldehyde dehydrogenase (ALDH)1A1. The latter is the main stemness mediator via enhancing signaling pathways of Wnt/β-catenin, phosphatidylinositol 3-kinase/AKT, and hypoxia. Furthermore, ALDH1A1 mediates therapeutic resistance by inactivating drugs, stimulating the expression of drug efflux transporters, and detoxifying reactive radical species, thereby apoptosis arresting. Recent reports disclosed the potent and broad-spectrum anticancer activities of the unique nanocomplexes of diethyldithiocarbamate (DE, ALDH1A1 inhibitor) with ferrous oxide nanoparticles (FeO NPs) mainly conferred by inducing lipid peroxidation-dependent non-apoptotic pathways (iron accumulation-triggered ferroptosis), was reported. Accordingly, the anti-stemness activity of nanocomplexes (DE-FeO NPs) was investigated against human and mouse glioma stem cells (GSCs) and radioresistant GSCs (GSCs-RR). DE-FeO NPs exhibited the strongest growth inhibition effect on the treated human GSCs (MGG18 and JX39P), mouse GSCs (GS and PDGF-GSC) and their radioresistant cells (IC50 ≤ 70 and 161 μg/mL, respectively). DE-FeO NPs also revealed a higher inhibitory impact than standard chemotherapy (temozolomide, TMZ) on self-renewal, cancer repopulation, chemoresistance, and radioresistance potentials. Besides, DE-FeO NPs surpassed TMZ regarding the effect on relative expression of all studied stemness genes, as well as relative p-AKT/AKT ratio in the treated MGG18, GS and their radioresistant (MGG18-RR and GS-RR). This potent anti-stemness influence is primarily attributed to ALDH1A1 inhibition and ferroptosis induction, as confirmed by significant elevation of cellular reactive oxygen species and lipid peroxidation with significant depletion of glutathione and glutathione peroxidase 4. DE-FeO NPs recorded the optimal LogP value for crossing the blood brain barrier. This in vitro novel study declared the potency of DE-FeO NPs for collapsing GSCs and GSCs-RR with improving their sensitivity to chemotherapy and radiotherapy, indicating that DE-FeO NPs may be a promising remedy for GBM. Glioma animal models will be needed for in-depth studies on its safe effectiveness.
Structural characterization and immunostimulant activities of polysaccharides fractionated by gradient ethanol precipitation method from Panax ginseng C. A. Meyer
Authors: Xu Mengran , Ren Jing , Jiang Ziye , Zhou Shuo , Wang Enpeng , Li Hui , Wu Wei , Zhang Xiaoyu , Wang Jing , Jiao Lili 
Published: April 2024

Panax ginseng C. A. Meyer is a dual-purpose plant for medicine and food, its polysaccharide is considered as an immune enhancer. Four polysaccharides, WGP-20-F, WGP-40-F, WGP-60-F and WGP-80-F were obtained from ginseng via water extraction and gradient ethanol precipitation with different molecular weights (Mw) of 1.720 × 106, 1.434 × 106, 4.225 × 104 and 1.520 × 104 Da, respectively. WGP-20-F and WGP-40-F which with higher Mw and a triple-helix structure are glucans composed of 4-ɑ-Glcp, do not show remarkable immunoregulatory effects. WGP-60-F and WGP-80-F are heteropolysaccharides mainly composed of 4-ɑ-Glcp and also contain t-ɑ-Araf, 5-ɑ-Araf and 3,5-ɑ-Araf. They are spherical branched conformations without a triple-helix structure and can effectively increase the index of immune organs, lymphocyte proliferation, activate macrophages to regulate the immune system in mice and further enhance immune functions by improving delayed-type hypersensitivity reaction and antibody response. These results indicated that WGP-60-F and WGP-80-F could be used as potential immune enhancers, and gradient ethanol precipitation can be applied for the preparation of ginseng bioactive polysaccharide.
Effect of circadian rhythm and menstrual cycle on physical performance in women: a systematic review
Authors: Beníčková Michaela , Gimunová Marta , Paludo Ana Carolina 
Published: April 2024

The literature has extensively investigated potential factors influencing women’s performance, including the menstrual cycle and the circadian rhythm. However, review articles exploring the combined influence of both factors remain lacking in the literature. The study aimed to systematically review the literature on the relationship between the circadian rhythm and menstrual cycle on physical performance in women. The review followed the PRISMA guidelines. The search was performed on the Web of Science, PubMed, Scopus, SPORTDiscus, and Google Scholar databases. Of the 1205 records identified, four articles met the inclusion criteria. From four articles, two studies found a significant interaction between the time of day and phase of the menstrual cycle with physical performance. The isometric strength increased in the afternoon in the mid-luteal phase (versus the morning in the mid-luteal phase, p &lt; 0.05), and the maximum cycling power was higher in the afternoon in the mid-follicular phase (versus the morning in the mid-follicular phase, p &lt; 0.01). Our findings suggest that the time of day and the menstrual cycle phase affect physical performance, with the daytime potentially having a more significant influence. However, the results should be interpreted cautiously due to the limited studies and diverse methodologies used to monitor the menstrual cycle phase. This review reinforces the need for further investigation to understand better the combined effects of the circadian rhythm and menstrual cycle on women’s physical performance.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=380965, identifier CRD42022380965.
Oxidative stress parameters in women and men with suicidal thoughts and following a suicide attempt
Authors: Lech Magdalena , Ostrowska Lucyna , Waszkiewicz Napoleon , Kułak-Bejda Agnieszka , Maciejczyk Mateusz , Witczak-Sawczuk Katarzyna , Zalewska Anna , Dańkowska Karolina , Żendzian-Piotrowska Małgorzata 
Published: April 2024

BackgroundThis study aimed to evaluate oxidative stress parameters in individuals with depression and schizophrenia, considering gender differences, and manifesting suicidal behavior, encompassing thoughts without a tendency to be realized, thoughts with a tendency to be realized, and suicide attempts.MethodsFrom among the patients from Department of Psychiatry 120 individuals were selected who met the inclusion criteria and did not meet the exclusion criteria for the study. In the initial phase of the project, patients eligible for the study underwent the M.I.N.I 7.0.2 questionnaire (Mini International Neuropsychiatric Interview). Subsequently, in the second phase of the research, venous blood samples were collected from the patients for the purpose of conducting biochemical assessments, focusing on oxidative stress parameters.ResultsThe obtained results suggest that redox biomarkers, namely TOS (total oxidation state) and OSI (TOS/TAC ratio), in the blood plasma of women increase in tandem with the severity of suicidal behavior. No notable alterations in SOD (Cu-Zn-superoxide dismutase), GPx (glutathione peroxidase), and GSH (reduced glutathione) concentrations and activity were noted between groups exhibiting suicidal behavior. The observed variations in the concentrations and activity of antioxidant parameters were significant solely in comparison to the control group.ConclusionsRedox biomarkers TOS and OSI could prove valuable in diagnosing women at a genuine risk of committing suicide. On the other hand, antioxidant parameters – SOD, GPx, and GSH may be instrumental in identifying patients with suicidal behaviors, without specifying their intensity.
General practice management after transition events: protocol for an experience-based co-design study
Authors: Shariff Zakia , Dale Jeremy , Spencer Rachel Ann 
Published: April 2024

Background
Discharge from hospital is a critical part of the patient journey, particularly for older patients with multimorbidity and polypharmacy. General practice has a key role in managing the post-discharge course of patients. A communication intervention for use in general practice in the immediate post-discharge period has great potential to improve shared decision making, enhancing patient experiences of post-discharge care.

Aim
General Practice Management After Transition Events (GP-MATE) aims to produce a tool for older patients and their carers (GP-MATE), which will assist better communication with their general practice about their care after discharge, thereby improving patient safety outcomes.

Design & setting
Experience-based co-design (EBCD) study involving general practices across the West Midlands.

Method
A slightly modified approach to EBCD will be followed to create GP-MATE. A focused ethnography undertaken at general practices will provide an understanding of practices’ systems for post-discharge management of older patients. Semi-structured video interviews with recently discharged older patients or their carers will be edited into a trigger film. Finally, co-design workshops with older people, carers, and healthcare staff working in general practices will take place with participants from three regions across England.

Conclusion
EBCD will be used to take a patient-centric approach towards creating GP-MATE; patients’ and carers’ priorities will be directly reflected within the tool. GP-MATE will be a low-cost intervention that improves health literacy, empowering patients to fill the emerging gap in continuity in the post-discharge period and enhancing patient experiences of post-discharge care.
Síndrome do desfiladeiro cérvico torácico: relato de caso
Authors: Cruz Francisca Yasminny Silva , Figueiredo Alberto Rubin , Guedes Louise Pessoa de Araújo , Nunes Barbra El Florencio , Soares Hugo Daniel Batista Reis , Oliveira Kariny Rodrigues de , Silva Adercio Pereira da , Alencar Cícero Rodrigues de Paiva 
Published: April 2024

A Síndrome do Desfiladeiro Cérvico Torácico (SDCT) é uma entidade clínica com sintomatologia diversa, decorrente de compressão anormal do plexo braquial, na região do desfiladeiro torácico. Esta compressão é exercida, na maioria das vezes, pelo músculo escaleno anterior, mas pode resultar também da existência de bandas musculofibróticas, alteração da morfologia da primeira costela, costelas cervicais e músculos anômalos. A SDCT pode ser classificada nos tipos arterial, venoso e neurogênico. Neste trabalho, relatamos dois casos de pacientes com sintomatologia e presença de costela cervical que foram operadas e tiveram resultado satisfatório. A SDCT acomete mais mulheres entre 20-50 anos, com vários fatores contribuintes, chegando a limitar as atividades diárias e laborais. O tratamento clínico, frequentemente, é a conduta inicial, com o objetivo de aliviar os sintomas. Em geral, o tratamento cirúrgico tem indicação em alguns casos dependendo da sua apresentação. Apesar da SDCT ser uma condição rara, é importante considerá-la no diagnóstico diferencial de pacientes com queixas de dor e parestesias em membros superiores.
A modified gentle human touch (GHT) to increase oxygen saturation levels on low birth weight infants: A study at a Private and Public Hospital in Central Java, Indonesia
Authors: Riadini Agi Yulia , Suwandono Agus , Runjati  
Published: April 2024

Background: Low birth weight (LBW) care in hospitals often causes discomfort and stress which affect changes in physiological function. Modification of gentle human touch with the left lateral position is described as a treatment for developmental care that supports the comfort and supportive position of the lungs which is expected to have a positive effect on oxygen saturation and respiratory frequency for infants.Aims: This study aimed to find the effect of gentle human touch modification with a left lateral position on oxygen saturation in LBW infants.Methods: This study used a quasi-experimental design study. The population in this study was 36 LBW babies who received care, selected at a private and public hospital in Central Java, Indonesia, using a consecutive sampling technique. The infants were then divided equally to: (i) a group who received a standard human touch given at the hospital, with a supine position (control), and (ii) a group where the infants have been provided with a modified gentle human touch with left lateral position (intervention). The statistical test used was Mann Whitney and Wilcoxon test.Results: From this study, it is acknowledged that modification gentle human touch with the left lateral position was more effective in increasing oxygen saturation than the control group when viewed from clinical changes. The oxygen saturation levels after intervention reached 98 to 99%. However, from the statistical analysis, it has been noted that the mean difference between the two groups is not significantly different at a level of 0.05.Conclusions: A modified gentle human touch with the left lateral position proposed in this study presents a positive contribution to the oxygen saturation of low birth weight infants. Thus, the findings may recommend the modification as a procedure in a hospital care unit for low birth weight infants at hospitals or at home.
Keywords: Gentle human touch, Left lateral position, Low birth weight babies, Oxygen saturation.
Received: 25 August 2018, Reviewed: 04 September 2018, Received: in revised form 26, February 2019, Accepted: 28 February 2019
DOI: 10.35898/ghmj-31549
PENGARUH KONFLIK TERHADAP MOTIVASI KERJA PEGAWAI PEMERINTAH DI DESA LAKATAN KABUPATEN TOLITOLI
Authors: Fathur Alfansyah , Adriani  
Published: April 2024

Penelitian ini bertujuan untuk mengetahui Pengaruh Konflik Terhadap Motivasi Kinerja Pegawai Pemerintah Desa Lakatan. Penelitian Ini Dilakukan Pada Kantor Desa Lakatan / Desa Lakatan Kecamatan Galang Kabupaten Tolitoli. Metode pengumpulan data yaitu observasi, wawancara dan teknik sampel yang digunakan adalah sampling jenuh. Metode analisis yang digunakan adalah menggunakan uji linear sederhana dan uji hipotesis. Berdasarkan hasil penelitian dapat disimpulkan bahwa Konflik Berpengaruh Terhadap Motivasi Kerja Pegawai Pemerintah Desa Di Desa Lakatan Kecamatan Galang Kabupaten. Tolitoli. Setelah melakukakan uji hipotetsis diketahui dari hasil analisis uji t diketahui nilai thitung 2,258 dan ttabel 1,690 sehingga dapat dikatakan bahwa variabel konflik terdapat pengaruh yang signifikan terhadap variabel motivasi pemerintahan.
PENGARUH SUASANA RESTO DAN KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN PADA LAN’S RESTO DAN CAFE LAHAT
Authors: Fitriadi Heri 
Published: April 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh suasana resto dan kualitas pelayanan berpengaruh terhadap pada kepuasan pelanggan pada Lan’s Resto dan Cafe Lahat baik secara simultan dan parsial. Sampel yang diambil sebanyak 90 responden. Teknik pengambilan sampel menggunakan Insidental Sampling. Penelitian ini menggunakan penelitian kuantitatif dimana terdapat dua variabel yaitu suasana resto dan kualitas pelayanan sebagai variabel bebas (independent) dan kepuasan pelanggan sebagai variabel (dependent). Dengan menggunakan sumber data diantaranya: data primer, data sekunder, populasi dan sampel. Metode pengumpulan data yang digunakan adalah: observasi, wawancara dan penyebaran kuesioner kepada sejumlah responden. Serta menggunakan alat ukur validitas dan reliabilitas, uji prasyarat analisis, selanjutnya menggunakan metode analisis data dengan menggunakan analisis regresi berganda, uji hipotesis berupa uji t dan uji F. Serta koefesien korelasi dan koefisien determinasi. Analisis data pada penelitian ini menggunakan bantuan SPSS 23.0. Dari hasil penelitian tersebut, dilihat secara parsial dengan uji t bahwa suasana resto terdapat berpengaruh yang positif terhadap kepuasan pelanggan dengan thitung (7,858) > 2,000, kualitas pelayanan berpengaruh positif terhadap kepuasan pelanggan dengan thitung (11,611) > ttabel (2,000) Selanjutnya dalam uji pengaruh secara simultan dengan uji F menunjukkan bahwa suasana resto dan kualitas pelayanan berpengaruh signifikan terhadap kepuasan pelanggan dengan Fhitung (175,825) > Ftabel (2,72). Dari hasil penelitian tersebut diharapkan dapat bermanfaat kepada semua pihak.
HÉRNIA INGUINAL: ABORDAGEM MÉDICA NO REPARO CIRÚRGICO
Authors: Ribeiro Ingrid Botelho , Santos Thainá Ferreira , Silva Enzo Manhães de Carvalho Reis , Godinho Thiago Reis , Silva Thales André Strabelli Neves da , Fortes Heloísa Alves , Rodrigues Gabriel Piva , Ponte Raul Valério , Mazzei Ana Ligia Silva Carvalho , Santos ⁠Suedivaldo Ferreira dos , Fernandes Caio Costa , Poscidônio Aline Granato Botelho 
Published: April 2024

A hérnia inguinal é uma condição comum em que parte do tecido, frequentemente uma alça intestinal, protrui através de uma fraqueza na parede abdominal na região da virilha. Assim, existem várias abordagens médicas disponíveis para o reparo cirúrgico, incluindo técnicas abertas e laparoscópicas. Dessa forma, a escolha da abordagem depende de vários fatores, como a experiência do cirurgião, a preferência do paciente, as características da hérnia e as condições médicas subjacentes. Esta revisão aborda as diferentes abordagens médicas no reparo cirúrgico da hérnia inguinal, discutindo as indicações, técnicas, resultados e complicações associadas a cada uma delas. Objetivo: Investigar a eficácia e segurança das diferentes abordagens médicas no reparo cirúrgico da hérnia inguinal. Metodologia: Foram utilizadas as bases de dados Cochrane, Scielo e Medline, buscando artigos publicados entre os anos de 2022 e 2024, nos idiomas Português ou Inglês. Considerações Finais: O estudo comparativo entre o reparo cirúrgico laparoscópico transabdominal pré-peritoneal de hérnia inguinal utilizando reparo suturado versus o uso de tacker não demonstrou diferenças significativas em termos de taxa de recorrência, complicações pós-operatórias ou tempo de recuperação. Ambas as técnicas mostraram-se eficazes e seguras para o tratamento da hérnia inguinal, sugerindo que a escolha entre as duas abordagens pode ser baseada em considerações individuais do paciente e preferências do cirurgião.