bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pendidikan Karakter Melalui Pembiasaan di Kelas III SDN Karanganyar Gunung 02 Semarang
Authors: Listyarini Ikha , Miyono Noor 
Published: April 2024

Fokus penelitian ini untuk mendiskripsikan pendidikan karakter melalui pembiasaan di sekolah dasar. Untuk mencapai tujuan dari penelitian di atas, menggunakan penelitian kualitatif yang bersifat deskriptif. Penelitian dilakukan di SDN Karanganyar Gunung 02 Semarang, dengan subyek penelitian adalah 25 siswa kelas III. Pengumpulan data dilakukan dengan mengadakan observasi atau pengamatan, wawancara, dan dokumentasi. Analisisi data dilakukan dengan memberikan penjelasan terhadap data yang telah dikumpulkan. Berdasarkan hasil analisis diperoleh di SDN Karanganyar Gunung 02 Semarang menunjukkan bahwa adanya pembentukan karakter melalui pembiasaan yang sudah diterapkan dan dijalankan di SDN Karanganyar Gunung 02 Semarang diantaranya: (1) Berdoa sebelum dan sesudah pembelajaran; (2) melaksanakan upacara bendera di hari Senin; (3) melaksanakan program literasi sekolah di hari Selasa; (4) melaksanakan kegiatan asmaul husna di hari Rabu; (5) melaksanakan apel pagi di hari Kamis; (6) melaksanakan senam pagi di hari Jumat dan jalan sehat di akhir bulan hari Jumat. Dengan adanya kegiatan pembiasaan yang sudah dijalankan tersebut merupakan implementasi dari cara-cara yang digunakan untuk membentuk karakter siswa di kelas III SDN Karanganyar Gunung 02 Semarang. Kata-kata Kunci : pendidikan, karakter, siswa kelas III
International Student Agency in Emergency
Authors: Kuzhabekova Aliya , Amankulova Zhuldyz 
Published: April 2024

This qualitative study uses data from interviews with 20 recipients of a Kazakhstani “Bolashak” scholarship to explore how international students overcome structural barriers and manifest agency in the conditions of public health emergency. The analysis addresses the gap in the scholarly literature on agency of international students by explicitly focusing on manifestations of agency in the experiences of students from Kazakhstan, who have not yet received sufficient attention in research, and by following the students in a variety of country destinations. In addition, in contrast to the majority of studies conducted in the past, instead of recruiting students on a campus of a specific university or in the context of a single country, this study recruits participants from among recipients of a government-sponsored scholarship. The findings are interpreted with the help of Relational Ecological Theory of Agency.
تأثير استراتيجية الانشطة المتدرجة في مستوى الاداء الفعالية لمراحل الوثب الطويل لدى الطلاب
Authors: Teacher. Shawkhan Ramadan Tawfiq  , Assis  prof .Dr. zardasht Mohammed rawuwf  
Published: April 2024

الملخص
يهدف البحث التعرف على تأثير الاستراتيجية الانشطة المتدرجة و اليقظة العقلية ومستوى الاداء فعالية الوثب الطويل للطلاب المتحقق لهذه الفعالية ، واما منهج البحث استخدمت الباحثان المنهج التجريبي لملائمتة متطلبات البحث ، اذ قام الباحثان بتحديد مجتمج البحث با طلاب المرحلة الاولى با لكلية التربية الاساسية التربية الرياضية باالجامعة السليمانية ، و بالغ عددهم (61) طالباً و طالبة ، بواقع (10) طالبة و(51) طالبا, حيث تم اختيار (38) طلاب بشكل عشوائي بواقع (19) طالبا لكل شعبة دراسية عشوائيا، عن طريقة القرعة، وتم توزيعهن على مجموعتين (تجريبية و ضابطة) ، اهم الاستنتاجات البحث : اثبتت إستراتيجية الانشطة المتدرجة والاسلوب المتبع فاعليتهما في تطوير مستوى الاداء لدى عينة البحث بين الاختبارات القبلية و البعدية ، و اثبتت إستراتيجية الانشطة المتدرجة فاعليتها في تطوير مستوى الاداء لدى عينة البحث بين الاختبارات البعدية لصالح المجموعة التجريبية .
Buddhist Higher Learning Horizon and Its Relation to Global Trends : The Trajectory of Global Buddhist Pedagogy
Authors: Jovini Jovini , Surya Julia , Utami Sri 
Published: April 2024

This study aims to dissect the challenges, identify the unique characteristics, and propose viable strategies for the seamless integration of local and global dimensions in higher Buddhist education. This study used the systematic literature review method with a qualitative approach. The research hinged on an extensive review of scholarly articles, primary texts, and reports on Buddhist education in Indonesia and internationally and then analyzed using thematic analysis. Results highlight that Indonesian Buddhist education possesses unique characteristics and mirrors global patterns, albeit with localized interpretations. The study underscored the importance of recognizing and integrating the Buddhayana spirit amidst global Buddhist sectarian diversities. The contribution of this review was twofold: first, it enriches the understanding of the specificities of Indonesian Buddhist higher education and its relation to global trends; second, it advocates for a harmonious blend of local and global in shaping the trajectory of global Buddhist pedagogy.
Screening parameters for diagnosing primary aldosteronism in patients with moderate to severe obstructive sleep apnea hypopnea syndrome and resistant hypertension
Authors: Yan Dien , Zou Xiaofan , Li Xiao , Zeng Qiao , He Hongbing , Guo Jianping , Wang Yulan , Zheng Huanhuan , Fu Jinxiang , Wang Meili , Peng Danping , Zhou Xiaozi , Luo Xian , Luo Jiahua , Li Shaofen , Liu Jinping , Hu Pingsheng , Shen Yunfeng 
Published: April 2024

BackgroundPatients with obstructive sleep apnea hypopnea syndrome (OSAHS) combined with resistant hypertension (RH) have a high risk of developing primary aldosteronism (PA). This study investigated the aldosterone-renin ratio (ARR), plasma aldosterone concentration (PAC), and plasma renin activity (PRA) to determine the optimal cutoff values for PA diagnosis in patients with OSAHS combined with RH.MethodsPatients diagnosed with moderate and severe OSAHS combined with RH were recruited from the inpatient clinic of the Department of Endocrinology at Ji'an Central Hospital between October 2020 and April 2023. The included patients were divided into PA and no-PA groups. Diagnostic accuracy measures were calculated for each group, and receiver operating characteristic (ROC) curves were generated.ResultsA total of 241 patients were included, of which 103 had positive ARR screening results in the diagnostic accuracy analysis and 66 were diagnosed with PA. PAC and ARR showed moderate predictive capacity for PA, with area under the curve (AUC) values of 0.66 [95% confidence interval (CI): 0.55–0.77] and 0.72 (95% CI: 0.63–0.82), respectively, while PRA exhibited a limited predictive capacity (AUC = 0.51, 95% CI: 0.40–0.63). Using 45 as the optimal cutoff value for ARR, the sensitivity was 86% and the specificity was 52%. The optimal cutoff value for PAC was 17, with a sensitivity of 78% and a specificity of 55%. Notably, in patients with severe OSAHS, ARR at screening demonstrated significant predictive value for PA, with an AUC of 0.84 (95% CI: 0.72–0.96), a sensitivity of 85%, and a specificity of 76%. Conversely, in patients with moderate OSAHS, only ARR demonstrated significant predictive value for PA diagnosis, while PAC did not demonstrate notable diagnostic value.ConclusionARR and PAC are initial screening tools for PA, facilitating early detection, particularly in low-resource settings. In patients with OSAHS and RH, the ARR and PAC thresholds for PA diagnosis may require more stringent adjustment.
To develop a prognostic model for neoadjuvant immunochemotherapy efficacy in esophageal squamous cell carcinoma by analyzing the immune microenvironment
Authors: Yehan Zhou , Sheng Qin , Hong Yang , Jiayu Li , Jun Hou , Juan Ji , Min Shi , Jiaxin Yan , Shangzhi Hu , Yi Wang , Qifeng Wang , Xuefeng Leng , Wenwu He , Xueyan Cheng , Yang Liu , Zongyao Huang 
Published: April 2024

ObjectiveThe choice of neoadjuvant therapy for esophageal squamous cell carcinoma (ESCC) is controversial. This study aims to provide a basis for clinical treatment selection by establishing a predictive model for the efficacy of neoadjuvant immunochemotherapy (NICT).MethodsA retrospective analysis of 30 patients was conducted, divided into Response and Non-response groups based on whether they achieved major pathological remission (MPR). Differences in genes and immune microenvironment between the two groups were analyzed through next-generation sequencing (NGS) and multiplex immunofluorescence (mIF). Variables most closely related to therapeutic efficacy were selected through LASSO regression and ROC curves to establish a predictive model. An additional 48 patients were prospectively collected as a validation set to verify the model’s effectiveness.ResultsNGS suggested seven differential genes (ATM, ATR, BIVM-ERCC5, MAP3K1, PRG, RBM10, and TSHR) between the two groups (P &lt; 0.05). mIF indicated significant differences in the quantity and location of CD3+, PD-L1+, CD3+PD-L1+, CD4+PD-1+, CD4+LAG-3+, CD8+LAG-3+, LAG-3+ between the two groups before treatment (P &lt; 0.05). Dynamic mIF analysis also indicated that CD3+, CD8+, and CD20+ all increased after treatment in both groups, with a more significant increase in CD8+ and CD20+ in the Response group (P &lt; 0.05), and a more significant decrease in PD-L1+ (P &lt; 0.05). The three variables most closely related to therapeutic efficacy were selected through LASSO regression and ROC curves: Tumor area PD-L1+ (AUC= 0.881), CD3+PD-L1+ (AUC= 0.833), and CD3+ (AUC= 0.826), and a predictive model was established. The model showed high performance in both the training set (AUC= 0.938) and the validation set (AUC= 0.832). Compared to the traditional CPS scoring criteria, the model showed significant improvements in accuracy (83.3% vs 70.8%), sensitivity (0.625 vs 0.312), and specificity (0.937 vs 0.906).ConclusionNICT treatment may exert anti-tumor effects by enriching immune cells and activating exhausted T cells. Tumor area CD3+, PD-L1+, and CD3+PD-L1+ are closely related to therapeutic efficacy. The model containing these three variables can accurately predict treatment outcomes, providing a reliable basis for the selection of neoadjuvant treatment plans.
Trunk control and acute-phase multifactorial predictors of community mobility after stroke: a longitudinal observational study
Authors: Alomari Randah Ahmed , BinMulayh Ejlal Abdullah , Alqarni Abdullah Mohammad , Alsobhi Mashael , Chevidikunnan Mohamed Faisal , Basuodan Reem , Khan Fayaz 
Published: April 2024

IntroductionStroke is a detrimental condition associated with long-term functional impairments that restrict community reintegration, which is an indicator of successful post-stroke functional recovery and rehabilitation. Additionally, trunk control is an understudied factor that may contribute to community mobility and participation after stroke. This study aimed to identify predictors of community mobility among stroke survivors in the acute phase, with a primary focus on trunk control, in addition to exploring the mediating and moderating role of predictive factors.MethodsA longitudinal observational study included 61 participants with acute stroke. Trunk control test (TCT) during sitting, stroke severity, quality of life, fear of falls, depression, and age was assessed during the acute phase as potential predictors. The community mobility outcome measure was assessed 3 months after baseline using the Reintegration to Normal Living Index (RNLI). Statistical analyses included correlation, linear regression, mediation, and moderation analyses.ResultsTrunk control test was the strongest predictor of RNLI among all factors (β = 0.72; 95%CI = 0.004–0.007; p ≤ 0.0001). Stroke severity, quality of life, fear of falls, and age significantly predicted RNLI (p &lt; 0.01). Higher age was a significant moderator of the relationship between TCT and RNLI (β = 0.002; p &lt; 0.001; 95% CI = 0.0001–0.0003).DiscussionThe findings highlight sitting trunk control impairment during the acute stage as a crucial predictor of reduced community mobility after stroke, where age over 60 years can moderate this relationship. The study emphasizes that addressing trunk control during early stroke rehabilitation may enhance community reintegration prospects.
Zuranolone for treatment of major depressive disorder: a systematic review and meta-analysis
Authors: Ahmad Abdullah , Awan Abdul Rafeh , Nadeem Natasha , Javed Aamir Shahid , Farooqi Mobeen , Daniyal Muhammed , Mumtaz Hassan 
Published: April 2024

BackgroundCurrent treatment modalities for Major Depressive Disorder have variable efficacies and a variety of side effects. To amend this, many trials for short term, well tolerated monotherapies are underway. One such option is Zuranolone (SAGE-217), which is a recent FDA approved antidepressant for Post Partum depression (PPD) and is undergoing clinical trials for PPD, major depressive disorder (MDD) and essential tremors (ET).ObjectivesPool currently available data that compare Zuranolone to Placebo for the treatment of Major Depressive Disorder and evaluate its efficacy and safety profile.MethodsWe retrieved data from PUBMED and SCOPUS from inception to July 2023. We included articles comparing Zuranolone or SAGE 217 with placebo in patients suffering from Major Depressive Disorder. Review Manager 5.4 was used to analyze the outcomes including changes in the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A) and Montgomery–Åsberg Depression Rating Scale (MADRS) scores from baseline as well as any treatment emergent adverse events (TEAEs) and severe adverse events.ResultsOur review analyzed 4 trials and the data of 1,357 patients. Patients treated with Zuranolone indicated a statistically significant effect in the change from baseline in HAM-D score (p = 0.0009; MD [95% CI]: −2.03 [−3.23, −0.84]) as well as in MADRS score (p = 0.02; MD [95% CI]: −2.30[−4.31, −0.30]) and HAM-A score (p = 0.03; MD [95% CI]: −1.41[−2.70, −0.11]) on 15th day when compared to the Placebo group. Zuranolone was also significantly associated with a higher response rate (p = 0.0008; OR [95% CI]: 1.63[1.14, 2.35]) and higher remission rate (p = 0.03; OR [95% CI]: 1.65[1.05, 2.59]) when compared with the placebo. As for safety, Zuranolone was significantly associated with 1 or more TEAE (p = 0.006; RR [95% CI]: 1.14[1.04, 1.24]) but an insignificant association with side effects that lead to drug discontinuation (p = 0.70; RR [95% CI]: 1.18[0.51, 2.76]) and serious adverse events (p = 0.48; RR [95% CI]: 1.46 [0.52, 4.10]) when compared with placebo.ConclusionZuranolone is an effective and safe drug for short course major depressive disorder monotherapy. It shows results in 14 days (compared to 2–4 weeks that SSRI’s take) and has anti-anxiolytic effects as well. However, only 4 trials have been used for the analysis and the sample size was small. The trials reviewed also cannot determine the long-term effects of the drug. More trials are needed to determine long term effects.
The hidden costs of working from home: examining loneliness, role overload, and the role of social support during and beyond the COVID-19 lockdown
Authors: Fostervold Knut Inge , Ulleberg Pål , Nilsen Odd Viggo , Halberg Anne Marie 
Published: April 2024

ObjectiveThis study evaluated the impact of the number of days per week working from home (WFH) on employee loneliness during and 2 years after the COVID-19 lockdown, with a focus on role overload as a mediating factor and social support from coworkers as a moderating variable.MethodsData were collected via self-reports from a sample of 6,918 participants during the lockdown in January 2021 and 6,576 participants 2 years post-lockdown in January 2023.ResultsAnalysis using a moderated mediation model showed that increased WFH days were associated with heightened loneliness during the lockdown, a link that weakened post-lockdown. Role overload served as a mediator, intensifying loneliness during WFH but less so after the lockdown. While higher social support was generally linked to reduced role overload and loneliness, it paradoxically intensified these issues in individuals with extensive WFH days.ConclusionsThe findings suggest that the number of days WFH can exacerbate loneliness and role overload among employees, with the effect being more pronounced during the lockdown. Employees with substantial social support faced more challenges as WFH duration increased. These results underscore the complex dynamics between WFH, social support, and employee wellbeing.
Minimally invasive surgical technique for unstable supracondylar humerus fractures in children (Gartland type III or IV)
Authors: Lee Chang-Hyun , Jung Sung-Taek , Park Chun-Gon , Kim Joonyeong , Kang Gyo Rim , Kim Sungmin 
Published: April 2024

BackgroundAchieving and maintaining anatomical reduction during the treatment of pediatric humerus fractures, classified as Gartland type III or IV, presents a clinical challenge. Herein, we present a minimally invasive surgical approach using a novel and simple K-wire push technique that aids in achieving and maintaining anatomical reduction.MethodsWe reviewed data of children receiving treatment for supracondylar fractures of the humerus at our hospital between January 2016 and December 2020. Patients were divided into two groups based on the method of treatment: Group 1 was treated with the K-wire push technique, and Group 2 was treated with the standard technique as described by Rockwood and Wilkins. The medical records and radiographic images were reviewed. In total, 91 patients with Gartland types III and IV fractures were included, with 37 and 54 patients in Groups 1 and 2, respectively.ResultsThe postoperative reduction radiographic parameters and Flynn scores at final follow-up were not significantly different between the two groups.ConclusionThe minimally invasive K-wire push technique for unstable supracondylar fractures in children is a safe and effective alternative for improving reduction. Using this technique, complications can be minimized, and the requirement for open reduction can be reduced.
Loose-patch clamp analysis applied to voltage-gated ionic currents following pharmacological ryanodine receptor modulation in murine hippocampal cornu ammonis-1 pyramidal neurons
Authors: Bertagna Federico , Ahmad Shiraz , Lewis Rebecca , Silva S. Ravi P. , McFadden Johnjoe , Huang Christopher L.-H. , Matthews Hugh R. , Jeevaratnam Kamalan 
Published: April 2024

IntroductionThe loose-patch clamp technique was first developed and used in native amphibian skeletal muscle (SkM), offering useful features complementing conventional sharp micro-electrode, gap, or conventional patch voltage clamping. It demonstrated the feedback effects of pharmacological modification of ryanodine receptor (RyR)-mediated Ca2+ release on the Na+ channel (Nav1.4) currents, initiating excitation–contraction coupling in native murine SkM. The effects of the further RyR and Ca2+-ATPase (SERCA) antagonists, dantrolene and cyclopiazonic acid (CPA), additionally implicated background tubular-sarcoplasmic Ca2+ domains in these actions.Materials and methodsWe extend the loose-patch clamp approach to ion current measurements in murine hippocampal brain slice cornu ammonis-1 (CA1) pyramidal neurons. We explored the effects on Na+ currents of pharmacologically manipulating RyR and SERCA-mediated intracellular store Ca2+ release and reuptake. We adopted protocols previously applied to native skeletal muscle. These demonstrated Ca2+-mediated feedback effects on the Na+ channel function.ResultsExperiments applying depolarizing 15 ms duration loose-patch clamp steps to test voltages ranging from −40 to 120 mV positive to the resting membrane potential demonstrated that 0.5 mM caffeine decreased inward current amplitudes, agreeing with the previous SkM findings. It also decreased transient but not prolonged outward current amplitudes. However, 2 mM caffeine affected neither inward nor transient outward but increased prolonged outward currents, in contrast to its increasing inward currents in SkM. Furthermore, similarly and in contrast to previous SkM findings, both dantrolene (10 μM) and CPA (1 μM) pre-administration left both inward and outward currents unchanged. Nevertheless, dantrolene pretreatment still abrogated the effects of subsequent 0.5- and 2-mM caffeine challenges on both inward and outward currents. Finally, CPA abrogated the effects of 0.5 mM caffeine on both inward and outward currents, but with 2 mM caffeine, inward and transient outward currents were unchanged, but sustained outward currents increased.ConclusionWe, thus, extend loose-patch clamping to establish pharmacological properties of murine CA1 pyramidal neurons and their similarities and contrasts with SkM. Here, evoked though not background Ca2+-store release influenced Nav and Kv excitation, consistent with smaller contributions of background store Ca2+ release to resting [Ca2+]. This potential non-canonical mechanism could modulate neuronal membrane excitability or cellular firing rates.
Differences in Albizia odoratissima genetic diversity between Hainan Island and mainland populations in China
Authors: An Qi , Feng Yuanheng , Yang Zhangqi , Hu La , Wu Dongshan , Gong Guifang 
Published: April 2024

BackgroundThis study aimed at exploring unique population genetic characteristics of Albizia odoratissima (Linn. f) Benth on Hainan Island to provide a scientific basis for its rational utilization and protection.MethodsIt analyzed the genetic diversity and structure of 280 individuals from 10 subpopulations of A. odoratissima from Hainan Island and Baise City using 16 expression sequence markers - simple sequence repeat markers.ResultsThe genetic diversity of Hainan population (I = 0.7290, He = 0.4483) was lower than that of the Baise population (I = 0.8722, He = 0.5121). Compared with the Baise population (Nm = 2.0709, FST = 0.1077), the Hainan Island population (Nm = 1.7519, FST = 0.1249) exhibited lower gene flow and higher degree of genetic differentiation. Molecular variance and genetic differentiation analyses showed that the main variation originated from individuals within the subpopulation. There were significant differences in the genetic structure between Hainan and Baise populations. It grouped according to geographical distance, consistent with the Mantel test results (R2 = 0.77, p = 0.001). In conclusion, the genetic diversity of the island A. odoratissima population was lower than that distributed on land, the two populations exhibited obvious genetic structure differences. Both the degrees of inbreeding and genetic differentiation were higher in the island population than in the land population.