bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis
Authors: Engesser Jonas , Khatri Robin , Schaub Darius P. , Zhao Yu , Paust Hans-Joachim , Sultana Zeba , Asada Nariaki , Riedel Jan-Hendrik , Sivayoganathan Varshi , Peters Anett , Kaffke Anna , Jauch-Speer Saskia-Larissa , Goldbeck-Strieder Thiago , Puelles Victor G. , Wenzel Ulrich O. , Steinmetz Oliver M. , Hoxha Elion , Turner Jan-Eric , Mittrücker Hans-Willi , Wiech Thorsten , Huber Tobias B. , Bonn Stefan , Krebs Christian F. , Panzer Ulf 
Published: May 2024

Abstract

Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (ANCA-GN). To date, treatment of most patients with ANCA-GN relies on unspecific immunosuppressive agents that harbor serious adverse effects and are sometimes only partially effective. By performing spatial and single cell transcriptome analysis, we characterized inflammatory niches in the kidneys of 34 patients with ANCA-GN and identified proinflammatory, cytokine producing CD4+ (Th1 and Th17 subsets) and CD8+ T cells (Tc1 and Tc17-like subsets) as a key pathogenic signature. Digital pharmacology identified ustekinumab, a monoclonal antibody targeting IL-12 and IL-23, as the most promising therapeutic drug to target. Based on these findings, four patients with relapsing ANCA-GN were treated with ustekinumab in combination with low-dose cyclophosphamide and steroids. Ustekinumab was given subcutaneously (90 mg) at weeks 0, 4, 12, and 24. Patients were followed up for 26 weeks. This treatment was well-tolerated and induced clinical response in all ANCA-GN patients, including improved kidney function and Birmingham Vasculitis Activity Score. Our findings suggest that immune-profiling-based targeting of pathogenic T cells in ANCA-GN patients with ustekinumab is a promising approach and warrants further investigation in clinical trials.
Earnings Management: A Synthesis of a Century of Research
Authors: Al-Asfour Fadi 
Published: May 2024

Abstract

This paper offers a comprehensive analysis of earnings management, synthesizing insights from the 100 most cited studies in this significant field of accounting research. Utilizing a robust methodology, we sourced citation counts as of January 1, 2024, from two leading academic databases: Web of Science and Google Scholar. This approach allowed for the identification and examination of pivotal works that have shaped understanding and discussions in the realm of earnings management. The range of citations for these influential studies is remarkable, reflecting their impact and importance in the academic community. The most cited paper in our analysis boasts a staggering 14,571 citations, indicating its central role in shaping the discourse around earnings management. Conversely, the least cited paper, with 599 citations, still contributes substantially to the field, underlining the depth and diversity of research in this area. Our analysis delves into various themes that emerge from these landmark studies, including the impact of corporate governance on earnings management practices, the influence of global and cultural variations, the role of audit quality, the complex interplay of managerial incentives, market reactions, regulatory changes, and the dichotomy between accrual-based and real earnings management. This thematic exploration not only highlights the nuanced and multifaceted nature of earnings management but also sheds light on the evolving methodologies and analytical approaches adopted by researchers over time. The findings from this synthesis offer critical insights into the mechanics of earnings management, its underlying motivations, and the broad spectrum of strategies employed by firms in different contexts. This paper contributes to the academic literature by providing a consolidated view of the most influential research in earnings management, drawing connections between various studies, and highlighting areas for future research. Our work serves as a valuable resource for academics, practitioners, and policymakers, offering a thorough understanding of the complexities and implications of earnings management in the contemporary financial reporting landscape.
Jurimetrics in the Reconstruction of the Joint Property Division Model for Wage-Earner Wives in Indonesia
Authors: Rouf Abd. 
Published: May 2024

The joint property division in Article 97 of the Compilation of Islamic Law (Kompilasi Hukum Islam/KHI) is one-half (1/2) as long as it is not specified otherwise in the marriage agreement. This is followed mainly by judges because of the legal certainty in it, but not for wives with double burdens who work to earn a living and are also housewives. This research aims to reconstruct the joint property division through jurimetrics analysis to obtain more objective and tested results because it is based on empirical data. This research is a normative law study with a descriptive approach. The data in this study are the Compilation of Islamic Law, and concepts, as well as other laws and regulations related to the joint property division analyzed with jurimetrics to get the ideal formulation and scale of division. The results obtained include several models of joint property division for wage-earner wives (breadwinners) along with the scale of formulation which are divided into two groups, namely the joint property division with a share of one-half for the former husband and wife and the joint property division with a share other than one-half for the former husband and wife according to the role taken by both. This research can be used as a reference by judges in deciding cases of joint property, especially related to the condition that a wife is a wage-earner.
The complex association between drinking water consumption and endemic gastrointestinal illness as shown by Swedish cohort studies
Authors: Säve-Söderbergh Melle , Toljander Jonas , Simonsson Magnus 
Published: May 2024

ABSTRACT

It is well known that municipal drinking water may be the cause of gastrointestinal illness (GII) outbreaks, but it is still unclear to what extent drinking water contributes to endemic GII. To explore this, we conducted a prospective cohort study among 6,955 adults in five municipalities in Sweden, collecting monthly GII episodes and mean daily cold drinking water consumption through SMS (Short Message Service). When the association between drinking water consumption and GII (all symptoms) and acute gastrointestinal illness (AGI, vomiting and/or three loose stools during a 24-h period) were assessed, there were indications that the association departed from linearity, following a unimodal shape. Among consumers in surface water areas, the highest risk of GII and AGI was generally seen among the average consumers, while the opposite was seen among groundwater consumers. The association however also seemed to be affected by neighbouring communities. The results of the study indicate that there is indeed an association between drinking water consumption and endemic GII, but the nature of this association is complex and likely affected by multiple factors, for example, water source type in the home and degree of exposure to drinking water from additional sources.
Enhanced removal of ciprofloxacin and associated antibiotic-resistant genes from wastewater using a biological aeration filters in combination with Fe3O4-modified zeolite
Authors: Ye Minzhi , Jiang Yiping , Qian Laying , Qiu Feng , Liu Zhiquan , Wang Zhu , Hu Chun 
Published: May 2024

ABSTRACT

Antibiotics release into the water environment through sewage discharge is a significant environmental concern. In the present study, we investigated the removal of ciprofloxacin (CIP) in simulated sewage by biological aeration filter (BAF) equipped with Fe3O4-modified zeolite (Fe3O4@ZF). Fe3O4@ZF were prepared with impregnation method, and the Fe3O4 particles were successfully deposited on the surface of ZF in an amorphous form according to the results of XPS and XRD analysis. The modification also increased the specific surface area (from 16.22 m²/g to 22 m²/g) and pore volume (from 0.0047 cm³/g to 0.0063 cm³/g), improving the adsorption efficiency of antibiotics. Fe3O4 modified ZF improved the treatment performance significantly, and the removal efficiency of CIP in BAF-Fe3O4@ZF was 79%±2.4%. At 10ml/L CIP, the BAF-Fe3O4@ZF reduced the relative abundances of antibiotics resistance genes (ARGs) int, mexA, qnrB and qnrS in the effluent by 57.16%, 39.59%, 60.22%, and 20.25%, respectively, which effectively mitigate the dissemination risk of ARGs. The modification of ZF increased CIP-degrading bacteria abundance, such as Rhizobium and Deinococcus-Thermus, and doubled bacterial ATP activity, promoting CIP degradation. This study offers a viable, efficient method to enhance antibiotic treatment and prevent leakage via sewage discharge.
Protective Effects of the Aqueous Extract of Malva sylvestris Plant against the
Lethality and Histopathological Damage in Experimental Envenoming of
Hemiscorpius lepturus Venom in Balb/c Mice
Authors: Ahmadi Sayyed Matin , Yousofpour Mohammad , Kamalinejad Mohammad , Otroshi Arman , Amiri Fereshteh Talebpour , Alipour Abbas , Zareinejad Mohammad Reza , Shahbazzadeh Delavar 
Published: May 2024

Introduction:
Hemiscorpius lepturus envenomation is a serious health problem in the southern
provinces of Iran. The antiserum produced in Iran to counteract this scorpion venom is not entirely effective
due to the risk of anaphylactic shock and other adverse effects.

Methods:
Therefore, more efficient alternatives to treat patients deserve attention, and plants are extensively
good candidates to be studied. This study aimed to assess the potential of the aqueous fraction of Malva
sylvestris in inhibiting the toxic effects of H. lepturus venom. Injection of sub-lethal dose of H. lepturus venom
leads to severe tissue damage in vital organs including the kidney, liver, heart and intestine, after 24 hours.

Results:
By injecting 80 mg of the aqueous extract of M. sylvestris into the peritoneum helped treat the damaged
tissues caused by H. lepturus venom in mice.

Conclusion:
Thus, Malva sylvestris could serve as an alternative treatment for scorpion sting envenomation
and may be used as a drug to neutralize relevant toxic effects in patients stung by H. lepturus.
Bioinformatics Approaches in the Development of Antifungal Therapeutics and Vaccines
Authors: Ahlawat Vaishali , Sura Kiran , Singh Bharat , Dangi Mehak , Chhillar Anil Kumar 
Published: May 2024

:
Fungal infections are considered a great threat to human life and are associated with
high mortality and morbidity, especially in immunocompromised individuals. Fungal pathogens
employ various defense mechanisms to evade the host immune system, which causes severe infections.
The available repertoire of drugs for the treatment of fungal infections includes azoles, allylamines,
polyenes, echinocandins, and antimetabolites. However, the development of multidrug
and pandrug resistance to available antimycotic drugs increases the need to develop better treatment
approaches. In this new era of -omics, bioinformatics has expanded options for treating fungal
infections. This review emphasizes how bioinformatics complements the emerging strategies,
including advancements in drug delivery systems, combination therapies, drug repurposing, epitope-
based vaccine design, RNA-based therapeutics, and the role of gut-microbiome interactions
to combat anti-fungal resistance. In particular, we focused on computational methods that can be
useful to obtain potent hits, and that too in a short period.
The Trend of Cesarean Hysterectomy in Hamadan, Iran, between 2009-2022
Authors: Radnia Nahid , Talebi-Ghane Elaheh , Tavilani Heydar , Garousian Maryam , Alimohammadi Neda , Ghorbani Marzieh 
Published: May 2024

Background and Objectives:
Hysterectomy is the emergency removal of the uterus after
a cesarean section (CS), usually performed after vaginal or cesarean deliveries, as a life-saving
measure to control heavy bleeding during childbirth. This surgery has many complications. However,
it has been increasing recently. The aim of this study is to determine the prevalence of hysterectomy
over time and to explore factors associated with hysterectomy.

Methods:
All patients with emergency hysterectomies following vaginal or cesarean delivery at the
Fatemieh Medical and Educational Center were included in this study. Risk factors and indications
for hysterectomy were recorded based on the study purpose.

Results:
The data indicated that out of 114175 deliveries, there were 60 hysterectomies over 14
years with the age range of 20-45 years. The incidence of hysterectomy increased from 0.34/1000
during 2009-2015 to 0.71/1000 deliveries in 2015-2022, with an overall incidence of 0.53 per 1000
deliveries during 14 years. The results indicated that the mean rate of hysterectomy (0.95% CI) increased
significantly by 0.059 yearly, and by adjusting other variables, the history of CS (0.95% CI)
and placenta accreta previa significantly increased the hysterectomy mean rate by 0.291 (0.053-
0.529) and 0.284 (0.074-0.494), respectively.

Conclusion:
The mean rate of hysterectomy represented an annual increase, especially during the
last 7 years. In summary, the main reason can be the history of CS that leads to placental disorders
and, thus, hysterectomy.
Polymeric Materials as a Promising Platform for Suppressing Protein
Aggregation Process
Authors: Ghosh Pooja , Mondal Anushree , De Priyadarsi 
Published: May 2024

Abstract:
The idea of designing novel anti-amyloid therapeutic agents has generated a lot of scientific interest and the potential for treating a variety of
human pathophysiologies, such as neurodegenerative and non-neuropathic diseases linked to amyloid protein aggregation. To address this,
different small molecules, peptides, surfactants, nanomaterials, etc., have been thoroughly investigated to learn more about their antiamyloidogenic
capabilities, offering a great deal of potential for them to show up as future anti-amyloidogenic agents. In contrast to existing smallmolecule
analogues, polymers have been envisaged as promising anti-amyloid agents for treating these diseases because of their enthralling
physicochemical features and simplicity of functionalisation. This review article emphasises the latest developments in the design of synthetic
polymers such as amino acid-conjugated polymers, glycopolymers, zwitterionic polymers and so on reported in the last decade in modulating
amyloid aggregation process. Additionally, the structural function and mechanism involved in modifying the aggregation process are highlighted in
order to inspire the researchers even more and provide insight into this important field of study.
A Systemic Review of Pre-clinical Studies of Herbal Plants having Anti-Polycystic Ovarian Syndrome Activity: A PAN-India Study
Authors: Karmakar Manashi , Chakraborty Binita , Hussain Amisha Sultana , Barbhuiya Pervej Alom , Chang Noksensangla Y. , Warjri Ireenia , Wankhar Wankupar , Barman Utpal , Basak Mrinmoy , Sen Saikat , Pathak Manash Pratim 
Published: May 2024

Background:
Polycystic ovarian syndrome (PCOS) is a prevalent endocrine and metabolic
condition seen in premenopausal women. A number of pharmacological agents like metformin,
oral contraceptives, and anti-androgen agents have been used to treat PCOS and its associated implications,
but it has been associated with numerous negative effects like fatal and nonfatal lactic acidosis,
weight gain, cardiovascular, and hepatic toxicity.

Methodology:
This study considered the Preferred Reporting Items for Systematic Review and Meta-
Analysis (PRISMA) guideline where a vast number of article sources from different scientific databases
like Google Scholar (https://scholar.google.com/), PubMed (https://pubmed.ncbi.nlm.nih.gov/),
and Web of Science (https://mjl.clarivate.com/search-results) were screened out.

Results:
From a total of 154 studies, 24 studies were screened out following the inclusion and exclusion
criteria, which reported 24 different plants that were used against PCOS preclinically. Details of
various plants used, including their respective families, plant parts utilized, extraction methods employed,
formulations developed, animal models of polycystic ovary syndrome (PCOS) utilized, and
the geographical locations within India where the research has been conducted are all documented.

Conclusion:
This systematic review is the first in India to report the pre-clinical studies of medicinal
plants against PCOS, and it provides a thorough summary of the application of medicinal plants for
the management of PCOS. Nonetheless, molecular level investigations on the plants utilized, their
bioactive phytoconstituent responsible for the anti-PCOS activity, the probable mechanism of action
and the pathway through which they conserve their effect, the effective dose, and the potential adverse
effects are the need of time.
Ideologies in outdoor public signs in Bali: A critical pragmatic and linguistic landscape study
Authors: Widiatmika Putu Wahyu , Sosiowati I Gusti Ayu Gde 
Published: May 2024

Outdoor public signs found in Bali contain ideologies and messages that can be mistakenly understood, potentially triggering conflicts. This study aims to identify and analyze the underlying ideology and the language functions in outdoor public signs found in Bali from the perspective of critical pragmatics and linguistic landscape. The data of this study were outdoor public signs that contain power relation from government and private stakeholders. The data were collected through observation and photography. The data were analyzed through referential and pragmatic identity methods with descriptive-qualitative approach. The theories applied were Halliday’s context of situation, Yule’s speech act, Fairclough’s critical discourse analysis, and Saussure’s signifier and signified. The results show that outdoor public signs in Bali have underlying ideologies, such as ethnocentrism, xenocentrism, and ecologism. The language functions are directive, commisive, and expressive. The ideologies represented by the language used can potentially cause conflicts as they may be sensitive to certain ethnic groups. The findings highlight the significance of critically examining public signage to understand its influence in shaping social dynamics and potential for unintended consequences.
Changes in the indicators of hemodynamics and oxygen transport in patients with idiopathic pulmonary arterial hypertension depending on their survival
Authors: Botsiuk Yu.A. , Sirenko Yu.M. 
Published: May 2024

Background. Idiopathic pulmonary arterial hypertension (IPAH) is a severe disease that affects the vessels of the pulmonary circulation and leads to right ventricular failure and death of patients. Indicators of hemodynamics and oxygen transport play central role in the progression and development of the disease. Objective: to evaluate indicators of hemodynamics, oxygen transport. Materials and methods. The study included 124 patients with IPAH. They were divided into two groups: alive patients (group 1) and those who died (group 2). All of them underwent general clinical examinations, a 6-minute walk test, transthoracic and speckle tracking echocardiography, right heart catheterization, blood gas analysis and calculation of hemodynamic parameters. Results. We calculated and compared the right (RVSWI) (19.93 ± 7.84 vs. 16.47 ± 4.67 g·m·m–2, p = 0.009) and left ventricular stroke work index (LVSWI) (39.47 ± 10.53 vs. 35.92 ± 11.19 g·m·m–2, p = 0.036) and their ratio (RVSWI/LVSWI) (0.59 ± 0.16 vs. 0.46 ± ± 0.13, p = 0.008), right (RVPC) (97.00 ± 2.16 vs. 1.82 ± 1.04 g·m, p = 0.001) and left ventricular pump coefficient (LVPC) (5.36 ± 4.84 vs. 4.41 ± 2.15 g·m, p = 0.04) and their ratio (RVPC/LVPC) (0.54 ± 0.19 vs. 0.44 ± 0.11, p = 0.05) in both groups of patients. Also, we found differences in partial pressure of carbon dioxide (PaCO2) of venous blood (34.5 ± 5.1 vs. 40.2 ± 6.9 mm Hg, p = 0.02), partial pressure of oxygen (PaO2) of arterial blood (90.2 ± 15.1 vs. 78.9 ± 11.2 mm Hg; p = 0.01), arteriovenous oxygen difference (A-vO2) (4.5 ± 1.2 vs. 5.0 ± 0.8 ml/dL, p = 0.02) between both groups. Conclusions. RVSWI, LVSWI, RVSWI/LVSWI, RVPC, LVPC, RVPC/LVPC were significantly different between the groups. The use of the above hemodynamic parameters can help in a deeper understanding of the prognosis in IPAH patients. Performance of oxygen transport indicators (PaCO2, PaO2) and A-vO2 in IPAH patients provides a broader understanding of the status and prognosis of this disease.
IN-VIVO ANTIDIABETIC POTENTIALS AND TOXICOLOGICAL EFFECT OF DENNETTIA TRIPETALA SEEDS ON ALLOXAN-INDUCED DIABETIC MALE ALBINO RATS
Authors: Alaebo Prince Ogochukwu , Egbuonu Anthony Cemaluk Chinedum , Achi Ngozi Kalu , Obike Chiemeziem Adanma , Ukpabi-Ugo Jacinta Chigozie , Ezeigwe Obiajulu Christian , Chukwu Uchechukwu Daniel , Wisdom Chukwuka Enyinna 
Published: May 2024

Background: Hyperglycemia and dyslipidemia are hallmarks of diabetes mellitus. Diabetes mellitus is a complex metabolic disorder characterized by disturbances in carbohydrates, protein, and lipid metabolism due to insufficient insulin production.
Aim: Present study was aimed to estimate the effects of Dennettia tripetala seed methanol extract (DTSE) on blood sugar and toxicological effect in alloxan-induced diabetes models using male wistar rats.
Methods: A total of thirty (30) male albino rats were divided into six distinct groups. Group A served as normal control group, where rats were neither induced nor treated. Group B acted as the negative control group, where rats were induced but not treated. Group C served as the positive control group, where rats were induced and treated with glibenclamide. Group D consisted of rats that were induced and treated with 100 mg of DTSE. Group E included rats that were induced and treated with 200 mg of DTSE. Lastly, group F comprised rats that were induced and treated with 400 mg of DTSE. Liver and kidney functions were determined using established analytical procedures. Blood samples were collected through ocular puncture for the evaluation of biochemical parameters.
Results: Blood glucose level in all the alloxan-induced diabetic rats treated with DTSE showed a relative significant (p<0.05) reduction when compared with the controls. Histological investigation of diabetic rat’s liver and kidney indicated degradation of normal tissue architecture, however after the treatment with DTSE minor reparative alteration were seen.
Conclusions: The study suggests that DTSE possesses a hypoglycemic effect, hepatoprotective and anti-atherogenic effect but has toxicological effect on the kidney of the rats treated with high dose of DTSE as pathological changes were elicited in the organ of the rats.

Peer Review History:
Received 6 February 2024; Revised 9 March 2024; Accepted 20 April; Available online 15 May 2024
Academic Editor: Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, amaka_mgbahurike@yahoo.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 8.0/10
Reviewers:
Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id
Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my
Mayada M. El-Azab, Phytochemistry Unit, Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, Egypt. drmayadaelazab2020@gmail.com