bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of adding lignin on preparation and properties of pitch/PAN‐derived electrospun nanofibers inducing cross‐linking structure
Authors: Zou Jialing , Li Mengzhu , Zhang Jiahui , Qi Yong , Yang Jianxiao , Zhang Aihua , Cao Jinchao 
Published: June 2024

AbstractIn this work, the content of lignin, pitch, and PAN as well as the preparation process would be systematically controlled in order to prepare carbon nanofibers (CNFs) with cross‐linked structure, high specific surface area, and good flexibility. The evolution of nanofibers with different lignin contents during stabilization and carbonization were explored, and the properties of the resultant CNFs as supercapacitor self‐supported electrodes were compared. The results indicated that with the increase of lignin content, not only cross‐linked structures were introduced in CNFs, but also the flexibility were obviously improved, accomplishing for supercapacitor self‐supported electrodes. Moreover, CNFs with different content of lignin varied in fiber morphology and microstructure, harvesting developed porous structure in CNFs. PPL3‐CNF prepared with adding lignin at a mass ratio of 3/7 into a concentration of 10 wt.% pitch/PAN solution presented the highest specific surface area of 949 m2 g−1, exhibiting an excellent specific capacitance of 190.7 F g−1 at 0.2 A g−1.
Validation of a high‐performance liquid chromatography method for determining lysophosphatidylcholine content in bovine pulmonary surfactant medication
Authors: Aghaei Mahsa , Talari Faezeh Shirgaei , Mollahosseini Afsaneh , Keramati Malihe 
Published: June 2024

AbstractPulmonary surfactant replacement therapy is a promising improvement in neonatal care for infants with respiratory distress syndrome. Lysophosphatidylcholine (LPC) is an undesirable component that can hinder surfactant proteins from enhancing the adsorption of surfactant lipids to balance surface tensions by creating a saturated coating on the interior of the lungs. A novel normal‐phase liquid chromatography method utilizing UV detection and non‐toxic solvents was developed and validated for the first time to analyze LPC in the complex matrix of pulmonary surfactant medication. The analytical method validation included evaluation of system suitability, repeatability, intermediate precision, linearity, accuracy, limit of detection (LOD), limit of quantification (LOQ), stability and robustness. The method yielded detection and quantification limits of 4.4 and 14.5 μg/ml, respectively. The calibration curve was modified linearly within the LOQ to 1.44 mg/ml range, with a determination coefficient of 0.9999 for standards and 0.9997 for sample solutions. Given the lack of reliable published data on LPC analysis in pulmonary surfactant medications, this newly developed method demonstrates promising results and offers advantages of HPLC methodology, including simplicity, accuracy, specificity, sensitivity and an exceptionally low LOD and LOQ. These attributes contribute to considering this achievement as an innovative method.
Ultra‐high‐performance liquid chromatography–mass spectrometry combined with molecular docking and molecular dynamics simulation reveals the source of bitterness in the traditional Chinese medicine formula Runchang‐Tongbian
Authors: Li Na , Li Chunyu , Zheng Aizhu , Liu Weipeng , Shi Yuwen , Jiang Mengcheng , Xiao Yusheng , Qiu Zhidong , Qiu Ye , Jia Ailing 
Published: June 2024

AbstractThe Runchang‐Tongbian (RCTB) formula is a traditional Chinese medicine (TCM) formula consisting of four herbs, namely Cannabis Fructus (Huomaren), Rehmanniae Radix (Dihuang), Atractylodis Macrocephalae Rhizoma (Baizhu), and Aurantii Fructus (Zhiqiao). It is widely used clinically because of its beneficial effect on constipation. However, its strong bitter taste leads to poor patient compliance. The bitter components of TCM compounds are complex and numerous, and inhibiting the bitter taste of TCM has become a major clinical challenge. Here, we use ultra‐high‐performance liquid chromatography coupled with mass spectrometry (UPLC–MS) and high‐resolution mass spectrometry to identify 59 chemical components in the TCM compound RCTB formula. Next, four bitter taste receptors, TAS2R39, TAS2R14, TAS2R7, and TAS2R5, which are tightly bound to the compounds in RCTB, were screened as molecular docking receptors using the BitterX database. The top‐three‐scoring receptor‐small‐molecule complexes for each of the four receptors were selected for molecular dynamics simulation. Finally, seven bitter components were identified, namely six flavonoids (rhoifolin, naringin, poncirin, diosmin, didymin, and narirutin) and one phenylpropanoid (purpureaside C). Thus, we proposed a new method for identifying the bitter components in TCM compounds, which provides a theoretical reference for bitter taste inhibition in TCM compounds.
Evaluation of the safety and efficacy of the Axiostat® dressing device to achieve radial artery access hemostasis: The R3A study
Authors: Nakache Ariel , Darmon Arthur , Molho Antoine , Steinecker Matthieu , Nejjari Mohammed , Digne Franck 
Published: June 2024

AbstractBackgroundRadial access is the default approach in interventional cardiology. The Axiostat® surgical hemostatic dressing, using chitosan as its active component, has demonstrated potential in accelerating blood clotting. This study aims to assess the efficacy and the safety of the Axiostat® dressing in achieving hemostasis in patients undergoing transradial coronary angioplasty (TRCA).MethodsThis prospective, single‐center observational study, conducted in 2022, enrolled consecutive patients undergoing TRCA, with a target of 150 participants. The primary outcome was the success rate of radial artery hemostasis at 120 min, without bleeding necessitating immediate re‐compression. The secondary outcome included Axiostat® performance at 24 h and 30 days Postprocedure.ResultsThe study was terminated prematurely for ethical and patient safety reasons, after inclusion of 41 consecutive TRCA patients due to an unexpectedly high radial artery thrombosis rate (19.5%, n = 8/41) observed 24 h Postprocedure. The success rate of radial hemostasis with the Axiostat® dressing was 78.0%. Procedural details and patient characteristics were comparable between successful Axiostat® removal and device failure cases.ConclusionThe use of the Axiostat® dressing to achieve hemostasis after TRCA is effective but is associated with an unexpectedly high incidence of radial thrombosis. Our results should encourage caution in the future evaluation and use of this device for radial artery compression following TRCA.
Axial Coordination Regulating Single Atoms for Enhanced CO2 Electroreduction
Authors: Lv Runyu , Chen Shan , Wang Huan 
Published: June 2024

AbstractWith the merits of high atomic utilization and well‐defined configuration, metal−nitrogen−carbon (M−N−C) single‐atomic catalysts (SACs), show great capability in selective reduction of CO2 into CO and formate. However, the metal center with the planar configuration of M−N4 has a highly symmetric structure, which is not conductive to charge transfer, thus limiting the intrinsic activity of SACs. Introduction of axially coordinated atoms with M−N4 center can break the symmetry and optimize the intermediate adsorption for accelerating CO2 reduction. Here, we briefly discuss the CO2RR pathway on single atoms and introduce the emerging synthetic methods for SACs with axial ligands. Then we review the axial coordination effect on CO2RR behavior. This review will be helpful for understanding the working mechanism of axially coordinated single atoms for enhancing CO2RR performance and thereby designing ideal coordination ligand in the axial direction.
The Influence of Metal Impurities on NiOOH Electrocatalytic Activity in the Oxygen Evolution Reaction
Authors: Watson Noë I. , Keegan Mark , van den Bosch Bart , Yan Ning , Rothenberg Gadi 
Published: June 2024

AbstractThe energy transition and the implementation of new electrochemical technologies will result in an increased reliance on critical raw materials for electrodes. Their large‐scale application will ultimately mean working with lower grade materials. Here we study the influence of metal impurities on nickel foam electrocatalysts. We do this by electrodepositing known amounts of first‐row transition metals (Cu, Cr, Mn, Fe, Co and Ni) on nickel foam and studying their performance in the oxygen evolution reaction (OER) as a model reaction. The electrodes’ performance is studied using cyclic voltammetry (CV), linear sweep voltammetry (LSV), Tafel analysis, stepwise chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS). Combining these results with microscopy analysis, we show that even small amounts of transition‐metal impurities have profound effects on the catalytic performance of nickel electrodes. The changes affect the OER onset potential (the energy that the system requires to convert OH– to O2) and the Tafel slope of each electrode (the electrode's initial activity in the OER onset region). Our results highlight the implications of such impurities on electrode design and future large‐scale application.
Activation of σ‐Bonds by Group 13/Ylide‐Based Ambiphiles: Understanding and Design
Authors: González‐Pinardo Daniel , Krämer Felix , Breher Frank , Fernández Israel 
Published: June 2024

AbstractThe factors controlling the activation of σ‐bonds promoted by hidden Frustrated Lewis Pairs have been computationally explored using quantum chemical tools. To this end, the influence of both the nature of the group 13 element acting as Lewis acid as well as the cooperative action of the Lewis antagonists on the bond activation was quantitatively analyzed by means of the activation strain model of reactivity in combination with the energy decomposition analysis method. It is found that while the activation of the polar EX−H bonds (E15=group 15 element; E16=group 16 element) is feasible, the analogous processes involving non‐polar E14−H bonds (CH4, SiH4 or H2) proceed with much higher barriers. Nevertheless, these processes, and in particular the dihydrogen activation, can be realizable (i. e. proceeding with a feasible barrier) through rational design.
Oral Irrigation Devices: A Scoping Review
Authors: Sarkisova Farzana , Morse Zac , Lee Kevin , Bostanci Nagihan 
Published: June 2024

ABSTRACTObjectivesSelf‐performed oral hygiene is essential for preventing dental caries, periodontal, and peri‐implant diseases. Oral irrigators are adjunctive oral home care aids that may benefit oral health. However, the effects of oral irrigation on oral health, its role in oral home care, and its mechanism of action are not fully understood. A comprehensive search of the literature revealed no existing broad scoping reviews on oral irrigators. Therefore, this study aimed to provide a comprehensive systematic review of the literature on oral irrigation devices and identify evidence gaps.MethodsThe Joanna Briggs Institute and Preferred Reporting Items for Systematic reviews and Meta‐Analyses extension for Scoping Reviews guidelines were utilized to prepare the review. Four databases and eight gray literature sources were searched for English publications across any geographical location or setting.ResultsTwo hundred and seventy‐five sources were included, predominantly from scientific journals and academic settings. Most studies originated from North America. Research primarily involved adults, with limited studies in children and adolescents. Oral irrigation was safe and well‐accepted when used appropriately. It reduced periodontal inflammation, potentially by modulating the oral microbiota, but further research needs to clarify its mechanism of action. Promising results were reported in populations with dental implants and special needs. Patient acceptance appeared high, but standardized patient‐reported outcome measures were rarely used. Anti‐inflammatory benefits occurred consistently across populations and irrigant solutions. Plaque reduction findings were mixed, potentially reflecting differences in study designs and devices.ConclusionsOral irrigators reduce periodontal inflammation, but their impact on plaque removal remains unclear. Well‐designed, sufficiently powered trials of appropriate duration need to assess the clinical, microbiological, and inflammatory responses of the periodontium to oral irrigation, particularly those with periodontitis, dental implants, and special needs. Patient‐reported outcome measures, costs, caries prevention, and environmental impact of oral irrigation need to be compared to other oral hygiene aids.
Titanium‐Immobilized Layered HUS‐7 Silicate as a Catalyst for Photocatalytic CO2 Reduction
Authors: Ricka Rudolf , Amen Tareq W. M. , Tsunoji Nao , Reli Martin , Filip Edelmannová Miroslava , Kormunda Martin , Ritz Michal , Kočí Kamila 
Published: June 2024

AbstractUtilizing photocatalytic CO2 reduction presents a promising avenue for combating climate change and curbing greenhouse gas emissions. However, maximizing its potential hinges on the development of materials that not only enhance efficiency but also ensure process stability. Here, we introduce Hiroshima University Silicate‐7 (HUS‐7) with immobilized Ti species as a standout contender. Our study demonstrates the remarkable photocatalytic activity of HUS‐7 in CO2 reduction, yielding substantially higher carbonaceous product yields compared to conventional titanium‐based catalysts TS‐1 and P25. Through thorough characterization, we elucidate that their boosted photocatalytic performance is attributed to the incorporation of isolated Ti species within the silica‐based precursor, serving as potent photoinduced active sites. Moreover, our findings underscore the crucial role of the Ligand‐to‐Metal Charge Transfer (LMCT) process in facilitating the photoactivation of CO2 molecules, shedding new light on key mechanisms underlying photocatalytic CO2 reduction.
Perceptions of cognitive decline among American Indian and Alaska Native elders
Authors: Allick Cole 
Published: June 2024

AbstractINTRODUCTIONAmerican Indian and Alaska Native elders aged ≥ 65 years are experiencing increased life expectancy. Elders are critical to intergenerational knowledge, yet limited data exist on the health challenges faced by this group.METHODSThis study engaged individuals attending the National Indian Council on Aging 2021 Annual Meeting in Reno, Nevada. A 19‐question survey, designed to examine perceptions about cognitive decline and to identify comfort with potential risk and protective factors, was disseminated to 50 participants.RESULTSParticipants indicated that they are concerned about cognitive decline, are willing to plan for their future care and cognitive testing, and articulated a desire for Tribally led long‐term support services.DISCUSSIONThis study found similar results to studies on White individuals, which include a lack of knowledge, stigma around the aging process, and gaps in services available. More work is necessary to address the gap in literature and policy.Highlights
American Indian and Alaska Natives (AI/ANs) are underrepresented in literature on Alzheimer's disease and related dementia (ADRD).
AI/ANs believe that they will experience cognitive decline as they age.
AI/ANs indicate a willingness to plan for future care and participate in future research on ADRD.
An assessment of nutrient removal by harvesting constructed floating wetlands in two coastal lagoons in the SE Baltic Sea
Authors: Lesutienė Jūratė , Bielecka Małgorzata , Petkuvienė Jolita , Razinkovas‐Baziukas Artūras 
Published: June 2024

AbstractIn the last decades, so‐called internal or sea‐based mitigation measures have been suggested as nature‐based solutions to remove nutrients and improve water quality in semi‐enclosed coastal waters. However, these have rarely been tested in the field, especially in colder climates where winter ice cover is common. The aim of this experimental research was to investigate plant growth conditions in such an environment, as well to estimate nutrient removal capacity by harvesting constructed floating wetlands (CFWs). We tested small (24–28 m2) CFWs (Biomatrix®, Scotland, UK) at two demonstration sites: the Curonian lagoon (CL, Lithuania) and Szczecin lagoon (SL, Poland). In the CL, CFWs were planted predominantly with Carex acutiformes (Ehrh.), while the SL CFW was planted mainly with the reed Phragmites australis (Cav.) Trin. ex Steud. We aimed to test the amount of nutrient removal by plant harvesting over three subsequent years (2019–2021). We investigated carbon storage capacity and plant nutrient stoichiometry as indicators of potential nutrient limitation in the brackish coastal waters. Plant biomass increased annually, stabilising at 2.5–3.7 kg wet weight m−2. The total nutrient uptake per installed island area varied with the plant species composition. In the successive years, the harvested plants from the CL CFW dominated by Carex accumulated 10.4–13.1 g N m−2, 0.6–0.8 g P m−2 and 318–431 g C m−2 per year. The harvest from the SL CFW dominated by Phragmites contained a two‐times higher amount of nutrients, the respective figures being 21.2 g N m−2, 1.6 g P m−2 and 704 g C m−2. The nutrient stoichiometry in the vegetation did not suggest the presence of sub‐optimal growth conditions due to nitrogen limitation. However, the CL's dissolved nutrient supply was very low during the summer cyanobacteria bloom and indicated a severe nitrogen deficiency (as reflected in the dissolved inorganic nitrogen:dissolved inorganic phosphorus [DIN:DIP] molar ratio of 6). We suggest that to maximise nutrient removal capacity, tall plants with high biomass should be selected and/or plants with fine root systems to efficiently uptake the limiting nutrient from the water.
Developing an eDNA approach for wetland biomonitoring: Insights on technical and conventional approaches
Authors: Bird Starsha , Dutton Paul , Wilkinson Shaun , Smith Josh , Duggan Ian , McGaughran Angela 
Published: June 2024

AbstractWetlands are ecologically and culturally significant ecosystems that are experiencing biodiversity declines globally. Biomonitoring techniques that use environmental DNA (eDNA) to detect and monitor biodiversity are well established in lake, riverine, and marine ecosystems. However, their use in wetlands requires further development due to the presence of sediments that block eDNA filters to limit water filtration, alongside a lack of standardized methodology. In this study, we examined eDNA dynamics to understand spatiotemporal biodiversity patterns in an Aotearoa New Zealand wetland and to optimize their application to wetland‐specific challenges. We sampled four sites across Opuatia Wetland at three time points during an austral spring. We conducted conventional taxonomic surveys, tested three different filter sizes (1.2 μm, 5 μm, and semi‐quantitative dacron filters), and assessed our ability to detect foreign DNA (from kea; Nestor notabilis) at different time points and distances post‐release. We found significant differences in DNA sequence composition across time and space, and when using different sized filters. eDNA data generally complemented (versus replaced) conventional survey and identification methods, with certain species only detected by one method or the other. Taxonomic resolution of conventional sampling and identification methods often exceeded that of eDNA. Foreign DNA was detectable 10 m from its release point for up to 1 week post‐release. Our results provide new considerations for future eDNA research in wetland environments, where rapid biomonitoring techniques are needed to support conservation and preservation.
Advancements in oral insulin: A century of research and the emergence of targeted nanoparticle strategies
Authors: Han Yue , Spicer Julie , Huang Yuan , Bunt Craig , Liu Mengyang , Wen Jingyuan 
Published: June 2024

AbstractWith the growing prevalence of diabetes, there is an urgent demand for a user‐friendly treatment option that minimizes side effects related to the use of subcutaneous injections. Scientists have dedicated over a century to developing an oral dosage form of insulin that can be administrated orally. The oral route of administration is the most desirable route for regularly dosed drugs in terms of safety and patient compliance. However, oral delivery of insulin remains a formidable challenge due to its intrinsically limited ability to cross the intestinal epithelium membrane and susceptibility to enzymatic degradation. This article reviews oral insulin research over the past decade, with a particular focus on surface modifications of nanoparticles (NPs). Various strategies involving controlling surface charges, utilizing protective proteins, and targeting specific receptors with ligands have been explored. Notably, surface modifications of the NPs for targeting specific intestinal receptors have shown promise in enhancing insulin oral absorption and bioavailability. Advanced technologies such as oral microneedles and gene therapy have also been developed, but their safety requires further assessment. Despite encouraging preclinical results across numerous strategies, the current clinical evidence is less optimistic. In summary, the present findings highlight the substantial journey that still lies ahead before achieving successful oral delivery of insulin.Practical Applications: This review provides a summary of recent progress in oral insulin delivery, particularly highlighting surface‐modified functional nanoparticles serving as an effective drug delivery system, which offers valuable information to the researchers. Due to the limited effectiveness of oral protein drugs caused by biological barriers, innovative technologies and drug delivery systems have been developed to overcome these obstacles and achieve therapeutic goals. This review concluded that surface modifications to nanoparticles can improve insulin stability and permeability, thereby enhancing oral bioavailability. It could assist researchers in developing more effective and patient‐friendly oral drug delivery systems.
Co‐constructing comunidad: A collective critical reflection on the co‐creation of La RED
Authors: Aponte‐Soto Lisa , Maldonado Saúl I. , Neubauer Leah C. , Hernandez Arthur 
Published: June 2024

AbstractThis article describes the co‐creation of the American Evaluation Association's Latinx Responsive Evaluation Discourse (La RED) Topical Interest Group by using a collective critical reflection approach to analyze the evolution of La RED as a platform for theory building and a community of practice during its foundational years (2014–2017). Ten years post instituting the TIG, the authors illustrate how the positionality of inaugural La RED Latine evaluators, their lived experiences, and their engagement in discourse on Critical Race Theory, Latine Critical Race Theory (LatCrit), culturally responsive evaluation, and community participatory approaches informed the conceptualization of Latine culturally responsive and equitable evaluation (LatCREE). LatCREE is introduced as an effective and appropriate framework for the study and practice of evaluation with Latine communities. We emphasize the value of discourse in comunidad as an essential actionable process for practicing LatCREE and offer epistemological, ontological, and axiological considerations for co‐constructing and sustaining comunidad as La RED Latine evaluators.