bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transvenous Embolization of a Symptomatic Venous Aneurysm Developing in the Drainage Network of a Deep Cerebral AVM: A Case Report
Authors: Benabu Yves , Roy Daniel , Guilbert Francois , Raymond Jean , Weill Alain 
Published: June 2010

ABSTRACT We present a case of a symptomatic venous aneurysm that developed in the drainage network of a deep‐seated basal ganglia and thalamic arteriovenous malformation. The venous aneurysm was treated selectively with platinum coils using a venous approach.
Multifocal Intradural Spinal AVF and Renal Artery Aneurysms in a Case of Klippel Trenaunay Syndrome (KTS)
Authors: Sharma Sandeep 
Published: June 2010

ABSTRACT We report an interesting case of a young patient who had hypertrophy of right leg and nevoid geographic skin lesion on the dorsal aspect of the right foot and leg suggestive of Klippel Trenaunay syndrome (KTS) and who presented for spinal digital subtraction angiography (DSA) to investigate the cause of progressive weakness of bilateral lower limbs. DSA revealed spinal arteriovenous fistulae (AVFs) at 3 levels and bilateral renal artery aneurysms. Although multiple intradural spinal cord AVFs and renal artery aneurysms are considered a feature of KTS, their clear demonstration in a single case either alone or together is not available in literature to the best of this author's knowledge. Existence of multifocal intradural fistulae in KTS calls for a detailed and complete spinal DSA even after a fistula is detected.
DWI Lesion Volume Reduction Following Acute Stroke Treatment with Transient Partial Aortic Obstruction
Authors: Hussain Muhammad S. , Bhagat Yusuf A. , Liu Songling , Scozzafava James , Khan Khurshid A. , Dillon William P. , Shuaib Ashfaq 
Published: June 2010

ABSTRACTBACKGROUND AND PURPOSE Diffusion‐weighted imaging (DWI) identifies acute cerebral ischemia and DWI lesions are thought to indicate irreversibly damaged areas. However, new evidence suggests that DWI lesions may be reversible, especially with reperfusion. We present a patient who showed substantial reversal of her acute DWI lesion following partial aortic occlusion with Neuroflo™, a novel dual balloon catheter (Neuroflo™, CoAxia, MN). METHODS Case report/literature review. RESULTS A 48‐year‐old woman presented with left‐sided weakness and demonstrated an acute DWI lesion in the right middle cerebral artery territory, with diffusion‐perfusion mismatch. She was enrolled into an experimental study in which a dual balloon catheter was inflated in the lower aorta. The patient improved and her postprocedure magnetic resonance image showed a significant reduction in lesion volume on diffusion and perfusion‐weighted imaging. At 1 month, a repeat computed tomography scan showed a small infarction in the right insula, lentiform nucleus, and frontal cortex. The patient had recovered with no significant disability at her 3‐month follow‐up. CONCLUSION Reperfusion can improve DWI lesions. Partial aortic obstruction with a novel dual balloon catheter may be useful to promote reperfusion.
The effects of lithium and anticonvulsants on brain structure in bipolar disorder
Authors: Germaná C. , Kempton M. J. , Sarnicola A. , Christodoulou T. , Haldane M. , Hadjulis M. , Girardi P. , Tatarelli R. , Frangou S. 
Published: June 2010

Germaná C, Kempton MJ, Sarnicola A, Christodoulou T, Haldane M, Hadjulis M, Girardi P, Tatarelli R, Frangou S. The effects of lithium and anticonvulsants on brain structure in bipolar disorder.Objective:  To investigate the effect of lithium, anticonvulsants and antipsychotics on brain structure in bipolar disorder (BD).Method:  A cross‐sectional structural brain magnetic resonance imaging study of 74 remitted patients with BD, aged 18–65, who were receiving long‐term prophylactic treatment with lithium or anticonvulsants or antipsychotics. Global and regional grey matter, white matter, and cerebrospinal fluid volumes were compared between treatment groups.Results:  Grey matter in the subgenual anterior cingulate gyrus on the right (extending into the hypothalamus) and in the postcentral gyrus, the hippocampus/amygdale complex and the insula on the left was greater in BD patients on lithium treatment compared to all other treatment groups.Conclusion:  Lithium treatment in BD has a significant effect on brain structure particularly in limbic/paralimbic regions associated with emotional processing.
Relation of chelation regimes to cardiac mortality and morbidity in patients with thalassaemia major: an observational study from a large Greek Unit
Authors: Ladis Vassilios , Chouliaras Giorgos , Berdoukas Vasilios , Moraitis Panagiotis , Zannikos Kirykos , Berdoussi Eleni , Kattamis Christos 
Published: June 2010

AbstractObjectives:  Cardiac complications because of transfusional iron overload are the main cause of death in thalassaemia major. New chelators and iron monitoring methods such as cardiac magnetic resonance (CMR) became available after the year 2000. We evaluated the impact of these new management options on cardiac mortality and morbidity.Methods:  The risk of cardiac death during 1990–1999 and 2000–2008 was compared. Furthermore, after 1999, morbidity, mortality and reversal of heart failure were evaluated according to chelation regime: desferrioxamine (DFO), deferiprone (DFP) and combination therapy of DFO and DFP. We also present preliminary results for deferasirox (DFX), a new oral chelator.Results:  Three hundred and fifty‐four patients were included in the de novo cardiac event evaluation, while 86 were included in the improvement component. The annual risk of cardiac death in patients aged between 20–30 and 30–40 reduced from 1.52% to 0.67% and 1.87% to 0.56%, respectively, before and after the year 2000. The risk for a de novo cardiac event for DFO was 9.1 times greater than that of DFP and 23.6 than with the combination of DFP and DFO. For DFX, there was one cardiac event over 269 patient‐years. The risk of cardiac death was 9.5 per 1000 patient‐years for DFO, 2.5 on DFP, 1.4 on combination. In the DFX group no cardiac deaths were recorded. The odds of improvement were 8.5 times greater with DFP and 6.1 with combination therapy compared to DFO.Conclusions:  The new chelation regimes, together with CMR have contributed significantly to the reduction in cardiac morbidity and mortality in patients with thalassaemia major.
Optical diagnostics in the oral cavity: an overview
Authors: Wilder‐Smith P , Holtzman J , Epstein J , Le A 
Published: June 2010

Oral Diseases (2010) 16, 717–728As the emphasis shifts from damage mitigation to disease prevention or reversal of early disease in the oral cavity, the need for sensitive and accurate detection and diagnostic tools become more important. Many novel and emergent optical diagnostic modalities for the oral cavity are becoming available to clinicians with a variety of desirable attributes including: (i) non‐invasiveness, (ii) absence of ionizing radiation, (iii) patient‐friendliness, (iv) real‐time information (v) repeatability, and (vi) high‐resolution surface and subsurface images. In this article, the principles behind optical diagnostic approaches, their feasibility and applicability for imaging soft and hard tissues, and their potential usefulness as a tool in the diagnosis of oral mucosal lesions, dental pathologies, and other dental applications will be reviewed. The clinical applications of light‐based imaging technologies in the oral cavity and of their derivative devices will be discussed to provide the reader with a comprehensive understanding of emergent diagnostic modalities.
Relationship between periodontal condition and arterial properties in an adult population in Japan
Authors: Furuta M , Tomofuji T , Ekuni D , Tamaki N , Yamamoto T , Azuma T , Irie K , Endo Y , Yamada S , Morita M 
Published: June 2010

Oral Diseases (2010) 16, 781–787Objective:  This study addressed the relationship between periodontal condition and second derivative of the finger photoplethysmogram (SDPTG) in Japanese adults.Subject and methods:  The Community Periodontal Index (CPI) and SDPTG were recorded in 415 subjects (mean age: 44.0 years). For assessing SDPTG, we mainly focused on the ratio of the absolute value of the height of the early negative ‘b’ wave and ratio of the late re‐decreasing ‘d’ wave to the height of the initial positive ‘a’ wave, namely the b/a and d/a ratios.Results:  The CPI score was positively correlated with the b/a ratio (P < 0.001), and negatively correlated with the d/a ratio (P < 0.001). Logistic regression analysis showed that subjects with CPI scores ≥3 were more likely to have a higher level (male >−0.69, female >−0.64) of b/a ratio (Odds ratio = 1.7, P = 0.026) and lower level (male ≤−0.29, female ≤−0.32) of d/a ratio (Odds ratio = 2.2, P = 0.001) than those with CPI scores 0–2, after adjusting for age, gender, smoking status, pulse rate and presence of hypertension.Conclusion:  There was a statistical association between the CPI scores and SDPTG indices in Japanese adults.
Suppressive effects of nicotine on the cytodifferentiation of murine periodontal ligament cells
Authors: Yanagita M , Kojima Y , Kawahara T , Kajikawa T , Oohara H , Takedachi M , Yamada S , Murakami S 
Published: June 2010

Oral Diseases (2010) 16, 812–817Objectives:  Tobacco smoking has been suggested to be one of the important risk factors of developing periodontal disease. Although epidemiological studies have shown the detrimental effects of smoking on periodontal disease, the effects of smoke compounds on gingival tissue are not well understood. The aim of this study was to evaluate the effects of nicotine, which is the major component of the thousands of chemicals that constitute cigarette smoke, for cytodifferentiation of murine periodontal ligament (MPDL) cell.Materials and methods:  Expression of nAChR subunits on MPDL cells was examined using RT‐PCR. The effects of nicotine on gene expression of extracellular matrices and osteoblastic transcription factors were evaluated by quantitative RT‐PCR. Mineralized nodule formation of nicotine‐treated MPDL cells was characterized by alizarin red staining.Results:  Murine periodontal ligament cells expressed several subunits of nAChR, which have functional calcium signals in response to nicotine. Gene expression of extracellular matrices and osteoblastic transcription factors were reduced in nicotine‐treated MPDL cells. In addition, mineralized nodule formation was inhibited in MPDL cells in the presence of nicotine.Conclusion:  Our findings indicate that nicotine may negatively regulate the cytodifferentiation and mineralization of MPDL cells.
Misnomers in oral pathology
Authors: Subramanyam RV 
Published: June 2010

Oral Diseases (2010) 16, 740–746Background:  Diseases which involve the oral cavity usually derive their names from either Greek or Latin. These terms are customarily based on etiology or description of the lesion. However, because of various reasons, some of these terms are misnomers.Objective:  To review commonly encountered misnomers in oral pathology.Conclusions:  Most of the misnomers encountered in oral pathology may arise from lack of understanding of underlying etiology, pathogenesis, histopathology, and/or concepts. Some misnomers are due to imprecise translations from word origins, etymological bungles, and/or factual errors. Clinical, histopathological, and/or etymological explanations are used to analyze and elucidate the nature of these misnomers. Alternative terms, where possible, have been suggested.
Comparative proteomic analysis of human oral fluids according to gender and age
Authors: Fleissig Y , Reichenberg E , Redlich M , Zaks B , Deutsch O , Aframian D J , Palmon A 
Published: June 2010

Oral Diseases (2010) 16, 831–838Background:  Recently, interest in finding disease bio‐markers in human body fluids including oral fluids (OF), mainly saliva has increased. However, the physiologic differences in salivary proteins according to gender and age should be explored to establish a clinical diagnostic tool.Objective:  To compare OF protein expression according to gender and age, using proteomic approaches.Materials and Methods:  Oral fluids from 27 healthy volunteers (14 males, 13 females) was collected and divided into three age‐groups. OF proteins were separated by means of 2D‐SDS‐PAGE. A total of 51 proteins in 37 protein spots were identified by ESI‐MS/MS.Results:  Gender differences revealed six proteins with significant higher expression in females, including β‐2‐microglobulin and transferrin. Age differences revealed decrease in expression of eight proteins with aging among males and seven proteins differentially expressed with aging among females including prolactin inducible protein, Ig‐k light chain, transferrin, and calgranulin‐B.Conclusion:  Proteomic analysis of OF revealed differences in protein expression according to gender and age and therefore can highlight future use of this technique for diagnostic purposes in health and in disease.
Immunohistochemical expression of SHH, PTC, SMO and GLI1 in glandular odontogenic cysts and dentigerous cysts
Authors: Zhang L , Sun ZJ , Chen XM , Chen Z 
Published: June 2010

Oral Diseases (2010) 16, 818–822Objective:  To investigate expression of the sonic hedgehog (SHH) signaling pathway components in glandular odontogenic cysts (GOCs), and dentigerous cysts (DCs).MATIERIALS AND METHODS: Immunohistochemical staining for SHH, patched (PTC), smoothened (SMO), and the transcriptional factor GLI1 were investigated in the 12 GOCs specimens and 20 DCs.Results:  In GOCs and DCs, immunoreactivity for SHH, PTC, SMO, and GLI1 were detected in the epithelial cytoplasm. Each of the genes of the SHH signaling pathway was expressed in similar patterns in the epithelial lining of the cysts. The expression of SHH, PTC, SMO, and GLI1 was significantly higher in epithelia than that of subepithelial fibroblasts (P < 0.01). No statistical difference among the labeling index of the epithelial lining among the different cyst types could be revealed.Conclusions:  The findings suggest that the proteins of the SHH signaling pathway are predominantly located within the epithelial components of GOCs and DCs. SHH signaling pathway may play a role in epithelial lining formation.
Comparison of Classical and Bayesian Approaches for Intervention Analysis
Authors: Santos Thiago R. , Franco Glaura C. , Gamerman Dani 
Published: June 2010

SummaryIntervention analysis has been recently the subject of several studies, mainly because real time series present a wide variety of phenomena that are caused by external and/or unexpected events. In this work, transfer functions are used to model different forms of intervention to the mean level of a time series. This is performed in the framework of state‐space models. Two canonical forms of intervention are considered: pulse and step functions. Static and dynamic explanation of the intervention effects, normal and non‐normal time series, detection of intervention, and study of the effect of outliers are also discussed. The performance of the two approaches is compared in terms of point and interval estimation through Monte Carlo simulation. The methodology was applied to real time series and showed satisfactory results for the intervention models used.
Oral cysticercosis: report of two cases with review of literature
Authors: Gadbail A.R. , Korde S. , Wadhwan V. , Chaudhary M. , Patil S. 
Published: June 2010

AbstractCysticercosis is the result of infestation with the larval stage of the tapeworm (Taenia solium). Cysticercosis is a potentially fatal parasitic disease when involving the central nervous system (neurocysticercosis). This article reports two cases of oral cysticercosis and reviews 133 reported cases in English language literature. The prevalence of oral cysticercosis was 3.5% out of 769 cases of cysticercosis. Tongue is the most commonly affected site followed by buccal mucosa and lower lip. Most oral lesions appeared as asymptomatic submucosal nodules. Multiple oral involvements have been reported in few cases. Both genders were nearly equally affected. Fine needle aspiration cytology has also been used for preoperative diagnosis. The definitive diagnosis was done histopathologically. Simple surgical excision was sufficient to ensure complete removal. It is important to carry out a detailed medical evaluation in every case, in order to exclude the presence of the parasite at other sites. Medical treatment with antihelminthics drugs such as Praziquantel and Albendazole used for multiple involvement and neurocysticercosis.
The Pyhäjärvi Cataract Study II. Criteria for cataract surgery
Authors: Kuoppala Jaana , Falck Aura , Winblad Ilkka , Tuulonen Anja 
Published: June 2010

Abstract.Purpose:  It is necessary to develop tools for patient selection to target cataract surgery to patients with the best expected outcomes. We used visual acuity, visual functioning 14 (VF‐14) test, the 15‐dimension health‐related quality‐of‐life questionnaire (15D) and the New Zealand priority criteria to evaluate the criteria for cataract surgery in a post hoc setting.Material and methods:  Ninety‐three consecutive patients living in a defined rural area in Finland had cataract surgery as a part of the Pyhäjärvi Cataract Study in 2003. Success of cataract surgery was defined as improvement of visual acuity by at least 2 lines and/or improvement of visual function measured by questionnaires.Results:  The patients with a visual acuity of 0.30 logMAR (0.5 Snellen decimal) or worse in the better eye and/or 0.52 logMAR (0.3 Snellen decimal) in the worse eye had successful surgery in 59–83% of cases depending on the definition of success. When subjective judgement was added, the success rates varied between 63% and 91%.Conclusion:  Setting indication criteria, it seems sufficient to use two global questions in addition to visual acuity: one on the subjective view on disability, and one on a more neutral view on visual function, such as the 15D item on vision. The VF‐14 did not perform any better than the single item counterparts.
Ocular motor function in relation to gross motor function in congenital and childhood myotonic dystrophy type 1
Authors: Aring Eva , Ekström Anne‐Berit , Tulinius Mar , Sjöström Anders 
Published: June 2010

Abstract.Purpose:  To assess ocular motor function in congenital and childhood myotonic dystrophy type 1 (DM1) and correlate the results with cytosine‐thymine‐guanine (CTG) repeat size, severity of the disease, myotonia and skeletal muscle function.Methods:  A cross‐sectional investigation into strabismus, versions/ductions, saccades, smooth pursuit movements and ptosis was performed on 49 individuals with a confirmed diagnosis of DM1, all diagnosed at <18 years of age and with >40 CTG expansion repeats. The results were correlated with myotonia as well as Hammersmith motor ability scale (HMA). In addition, the ocular results were compared to results from an age and‐ sex‐matched control group.Results:  Ocular motor abnormalities were seen in 82%; the most frequent findings were altered conjugate eye movements and ‘pseudoptosis’ while blepharoptosis was rare. Strabismus was most common in the severe congenital subgroup, with a frequency 14 times higher than in the control group. Positive correlations were seen between CTG repeat size and affected eyelids, and between myotonia and affected eyelids; both these findings were most prominent in the mild congenital group. CTG repeat size was also correlated with version/duction defects, and most obviously in the childhood group. Low HMA scores were associated with high occurrence of strabismus and version/duction defects.Conclusion:  Abnormalities of ocular motor function are frequently present. CTG repeat size correlates positively with altered versions/ductions and eyelid pathology. Gross motor dysfunction correlates with strabismus and defect versions/ductions, and eyelid pathology indicates involvement of myotonia.
Inflorescence characteristics, seed composition, and allometric relationships predicting seed yields in the biomass crop Cynara cardunculus
Authors: ARCHONTOULIS S. V. , STRUIK P. C. , YIN X. , BASTIAANS L. , VOS J. , DANALATOS N. G. 
Published: June 2010

AbstractCynara (Cynara cardunculus) is a perennial C3 herb that has its potential as bioenergy crop. This paper aims (a) to derive empirical relationships to predict cynara seed yield per head and per unit area, avoiding laborious extraction of seeds from the complex structure of its inflorescences; (b) to determine the head‐weight distribution per unit area, the seed composition and the oil profile of cynara seeds; and (c) to estimate the range of cynara biomass, seed and oil yield in representative parts of Greece. We analyzed 16 field experiments, varying in crop age and environmental conditions in Greece. Seed yield per head (SYhead) can be accurately predicted as a linear function of dry head weight (Hw): SYhead=0.429·Hw−2.9 (r2=0.96; n=617). Based on this relationship, we developed a simple two‐parameter equation to predict seed yield per unit area (SY): SY=HN·(0.429·μ−2.9), where μ is the mean head weight (g head−1) and HN is the total number of heads per unit area, respectively. The models were tested against current and published data (n=180 for head‐level; n=35 for unit area‐level models), and proved to be valid under diverse management and environmental conditions. Attainable cynara seed yields ranged from 190 to 480 g m−2 yr−1, on dry soils and on aquic soils (shallow ground water level). This variation in seed yield was sufficiently explained by the analyses of head‐weight distribution per unit area (small, medium and large heads) and variability of seed/head weight ratio at head level. Seed oil concentration (average: 23%) and crude protein concentration (average: 18.7%) were rather invariant across different seed sizes (range: 26–56 mg seed−1) and growing environments.
Global mapping of Jatropha curcas yield based on response of fitness to present and future climate
Authors: TRABUCCO ANTONIO , ACHTEN WOUTER M. J. , BOWE COLM , AERTS RAF , ORSHOVEN JOS VAN , NORGROVE LINDSEY , MUYS BART 
Published: June 2010

AbstractAlthough acclaimed as a biofuel crop with high potential to sustainably replace fossil fuels, Jatropha curcas L. remains a poorly studied plant. Reliable yield assessments with conventional methods require agroclimatic and physiological knowledge, which is not yet available for Jatropha. To fill this gap, we tested a novel two‐step approach integrating knowledge from biogeography and population biology with available Jatropha field data. In the first step, using MaxEnt, a widely implemented model in biogeography, we predicted Jatropha fitness in response to climate by relating natural occurrence recorded in herbaria with bioclimatic geodatasets. In the second step, we relied on population biology principles supported by seed mass addition experiments to relate fitness to reproductive potential, hence seed yield. Jatropha seed yield in response to climate was mapped worldwide for actual (1950–2000 average) and future (2020) climate conditions. The modelled Jatropha seed yield was validated against a set of on‐field yield assessments (R2=0.67, P<0.001). The discrepancies between estimated and measured yields were partially explained by model uncertainties, as quantified by the sensitivity analysis of our modelling (R2=0.57, P=0.001). Jatropha has a pan‐tropical distribution, plus specific adaptability to hot temperate areas. Climate variables most significantly affecting modelled yield response were annual average temperature, minimum temperature, annual precipitation and precipitation seasonality.