bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmental physiotherapy: knowledge, attitudes, and practices among physiotherapists in Iceland
Authors: Olafsdottir Steinunn A. , Petursdottir Lilja Salome H. 
Published: February 2025

IntroductionWith growing concerns about climate change and the healthcare sector's carbon footprint, integrating sustainable practices into physiotherapy could not only reduce this impact but also enhance patient outcomes. This study explores the knowledge, attitudes, and practices of physiotherapists in Iceland regarding climate change and their role in promoting sustainability.MethodsA cross-sectional survey was distributed to active members of the Icelandic Physiotherapy Association. A total of 114 physiotherapists participated (17.1% response rate). The survey, consisting of 21 questions across four themes—knowledge, attitudes, behavior, and obstacles—captured insights on respondents' understanding of climate change, their environmental practices, and the challenges they encounter.ResultsThe results revealed a strong awareness of the relevance of climate change to health, though many respondents acknowledged limited knowledge on the topic. A majority expressed a sense of responsibility to mitigate climate change and reported taking actions such as reducing waste and promoting energy conservation. However, many identified a need for more guidance and training to integrate sustainable practices effectively. The primary obstacle was insufficient knowledge on implementing environmental strategies, with respondents indicating that education and resources would help overcome this barrier.DiscussionThis study highlights the potential for physiotherapists to contribute significantly to the healthcare sector's sustainability goals. The respondents' desire to enhance their environmental practices suggests an opportunity for professional associations and educational institutions to provide targeted training and support. By fostering greater environmental literacy, physiotherapists could not only contribute to reducing the healthcare sector's carbon footprint but also promote sustainable health behaviors in patients. Enhanced knowledge and support could help physiotherapists become key contributors to sustainability in healthcare.
Effect of Supplementation with a Specific Probiotic (Bifidobacterium bifidum PRL2010) in Pregnancy for the Prevention of Atopic Dermatitis in Children: Preliminary Results of a Randomized Trial
Authors: Anania Caterina , Matys Viviana , Marra Simona , De Canditiis Daniela , Olivero Francesca , Carraro Carlo , Giugliano Anna , Zicari Anna Maria , Piccioni Maria Grazia 
Published: February 2025

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the appearance of recurrent eczematous lesions and intense itching. The World Allergy Organization (WAO) suggested the administration of probiotics in pregnant women at high risk of allergies in their children. Objectives: Our study aims to evaluate the role of administering the Bifidobacterium bifidum strain PRL2010 during pregnancy and breastfeeding in preventing and/or reducing the severity of AD manifestations in children. Methods: It is a monocentric, randomized, double-blind, placebo-controlled trial with probiotic/placebo administration since the 36th week of gestation to mothers with atopy or a family history of atopy; the effects were evaluated over the first 12 months of the children’s lives. Results: No severe adverse effects due to probiotic intake were reported in our cohort. Although proportionally fewer children with AD were in the probiotic group, the statistical analysis showed no significant differences between the probiotic and placebo groups. However, infants who developed the most severe forms of AD in the probiotic group showed a better clinical course during follow-up compared to those in the placebo group. Conclusions: In conclusion, administering the probiotic Bifidobacterium bifidum strain PRL2010 during pregnancy and breastfeeding is safe and potentially beneficial; further large-scale studies may confirm its usefulness in improving the clinical manifestation of AD in children with a family history of atopy.
LITERATURE REVIEW RESIKO KANKER LEHER DAN KEPALA PADA PENGUNAAN TEMBAKAU KUNYAH
Authors: Tuhumury Filian , Kertadjaya Wiwi , Purnamawati Purnamawati 
Published: February 2025

Kanker adalah penyakit yang ditandai dengan tumbuhnya sel-sel jaringan tubuh yang tidak normal yang lalu berubah menjadi sel kanker. Diantara banyak jenis kanker, Kanker kepala dan leher merupakan salah satu jenis kanker yang berkembang di sekitar jaringan dan organ kepala serta leher. Beberapa faktor risiko yang dapat meningkatkan peluang seseorang terkena kanker kepala dan leher adalah Merokok tembakau, termasuk diantaranya tembakau kunyah. Penggunaan tembakau kunyah menghasilkan lebih dari 70 karsinogen, seperti nitrosamine khusus tembakau (TSNA / Tobacco spesific nitrosamines),polisiklik hidrokarbon aromatik ,aldehida, dan logam berat. sebagai penyebab utama kanker kepala dan leher. Literature review ini dibuat untuk mengetahui resiko kanker leher dan kepala pada pengunaan tembakau kunyah. Metode dalam pembuatan literatur review ini berupa tinjauan kepustakaan dengan mengumpulkan beberapa landasan teori dari berbagai jurnal penelitian, internet, dan artikel ilmiah lainnya. mengumpulkan jurnal penelitian dari berbagai database untuk dianalisis. Jurnal atau artikel yang didapatkan merupakan hasil dari pencarian di Google Scholar, ProQuest dan PubMed. Hasil dari Literatur review ini menunjukan bahwa terdapat hubungan yang bermakna antara resiko kanker kepala dengan pengunaan tembakau kunyah.
Embedded scalar diversity
Authors: Ronai Eszter 
Published: February 2025

This paper is an experimental investigation of embedded scalar implicatures in the context of scalar diversity. We test whether a sentence such as Every student read some of the books leads to the implicature that No student read all of the books, and similarly whether Every soup was warm leads to the implicature that No soup was hot—across 42 different lexical scales. We find 1) that embedded implicatures arise; 2) that there is across-scale variation in embedded implicatures, paralleling scalar diversity among global implicatures; and 3) that properties of alternatives (namely, semantic distance and boundedness) that predict global scalar diversity predict variation at the embedded level too. It is argued that these findings are most compatible with an account of embedded implicatures that builds on alternatives, such as the grammatical theory (i.a., Chierchia 2004; Chierchia, Fox & Spector 2012), a modified neo-Gricean account such as Sauerland (2004), or the “neo-Gricean uncertainty” version of the Rational Speech Act with lexical uncertainty account (RSA-LU, Potts, Lassiter, Levy & Frank 2015). They are, however, less compatible with the “unconstrained uncertainty” RSA-LU model (Bergen, Levy & Goodman 2016; Potts et al. 2015), which leaves unexplained (without further assumptions) why the same alternative-driven variation should occur both in global and embedded implicatures.
Fomento de la Cultura Ambiental a través de la Reforestación de las Zonas Verdes con Semillas de Árboles Nativos en la I.E.C.E.M. del Municipio de Solano Caquetá
Authors: Bermúdez Sepúlveda William de Jesús , Hurtado Torres Amparo 
Published: February 2025

En esta investigación se aborda la importancia de la conservación ambiental como responsabilidad compartida de toda una comunidad, destacando el papel crucial de la educación en la formación de ciudadanos comprometidos con la protección de los recursos naturales. Se propone la reforestación de zonas verdes con semillas de árboles nativos como una estrategia efectiva para fomentar la cultura ambiental entre los estudiantes de quinto grado de la Institución Educativa Campo Elías Marulanda, en Solano, Caquetá. En este mismo contexto, el planteamiento del problema surge de la falta de conciencia ambiental entre los estudiantes, y se establece como objetivo general la generación de cultura ambiental a través de la reforestación. Se destaca, la importancia de la participación de la comunidad educativa y estudiantil en este proceso, reflexionando sobre cómo mejorar la cultura ambiental y diseñando una estrategia pedagógica centrada en la reforestación de zonas verdes de la Institución en mención. Igualmente, la justificación y viabilidad de este proyecto se sustentan en los múltiples beneficios que la reforestación con árboles nativos ofrece, tanto a nivel ecológico, cultural y social. Se resalta la colaboración con entidades y la comunidad educativa como elementos clave para llevar a cabo esta iniciativa, que se espera tenga un impacto positivo en el entorno escolar y en la conciencia ambiental de toda la comunidad educativa.
Analysis of Risk Factors Associated with Measles Incidence in Toddlers in South Halmahera Regency
Authors: Abdullah Syarif , Anggraini Novita Ana , Peristiowati Yuly 
Published: February 2025

Measles is an internal disease (VPD) caused by Morbilivirus. This disease is characterized by the appearance of fever, reddish spots, cough, runny nose, red eyes and rashes all over the body which generally occurs in children. Measles, also known as Morbili or Measles, is a disease caused by the measles virus of the Paramyxovirus group. Transmission can occur through air that has been contaminated by droplets (spit) of an infected person. This case tends to attack early childhood and elementary school age children. Once a person has had measles, he or she will have lifelong immunity to the disease The aim of this research is to determine the factors related to the incidence of measles in toddlers in South Halmahera Regency. The research design used is quantitative research using a "case control" approach. The sampling technique used was purposive sampling with a sample of 106 consisting of 53 case groups and 53 control respondents. Data analysis techniques use Chi Square, Multivariate and Logistic Regression tests. The results of the research show that of the 106 respondents studied, the factors that most influence the incidence of measles in toddlers 0 - 59 months based on the beta value and p value, it is found that the environmental variable has a value < α, namely .021 and the beta value is -1.830, so the variable with the most dominant is the environment. Conclusion. The factors that most influence the occurrence of measles are environmental factors, so it is necessary to conduct socialization or education on the importance of environmental cleanliness to prevent the emergence of measles in children under five.
Transmettre l’horreur : Annihilation (2014) comme réécriture de Heart of Darkness (1899)
Authors: Rider Georges Pillegand-Le 
Published: February 2025

Cet article explore les résonances de Heart of Darkness de Joseph Conrad dans le roman Annihilation de Jeff VanderMeer. L’écrivain contemporain, figure phare du New Weird, reconfigure la manière dont l’humain envisage son rapport au non-humain. Partant de la littérature éco-critique qui existe sur Heart of Darkness, l’analyse proposée en applique les constats à VanderMeer. Puisque des scènes et motifs du roman de Conrad sont repris explicitement, il s’agit aussi de comprendre comment Annihilation s’en affranchit. L’étude replace donc l’œuvre d’une part dans le genre hybride du New Weird, qui rompt avec les ambiances de Joseph Conrad et certains de ses positionnements ; et, d’autre part, dans un type de récits, celui des invasions extraterrestres, qui, par le prisme d’une compréhension de l’humain et de son environnement terrestre, offre des réflexions particulièrement stimulantes. Dans un récit où la “horror” de Kurtz devient, chez VanderMeer, l’“annihilation” que hurle une psychologue mourante, l’analyse s’attellera enfin à réfléchir aux symboliques de pouvoir et aux capacités d’agir des personnages. Bien que les agentivités plurielles que les deux œuvres imaginent se répondent, Annihilation parvient à dépasser les limites de ce qui était envisagé dans Heart of Darkness en proposant de nouvelles subjectivités.
New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer
Authors: Shang-Guan Xin-Chang , Zhang Jun-Rong , Lin Chao-Nan , Chen Shuai , Wei Yong , Chen Wen-Xuan , Pan Lin , Huang Li-Qin , Zheng Shao-Hua , Chen Xian-Qiang 
Published: February 2025

BACKGROUND
The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer (OCRC). The existing assessment still relies on the colorectal obstruction scoring system (CROSS) which is based on a comprehensive analysis of patients’ complaints and eating conditions. The data collection relies on subjective descriptions and lacks objective parameters. Therefore, a scoring system for the evaluation of computed tomography-based obstructive degree (CTOD) is urgently required for OCRC.
AIM
To explore the relationship between CTOD and CROSS and to determine whether CTOD could affect the short-term and long-term prognosis.
METHODS
Of 173 patients were enrolled. CTOD was obtained using k-means, the ratio of proximal to distal obstruction, and the proportion of nonparenchymal areas at the site of obstruction. CTOD was integrated with the CROSS to analyze the effect of emergency intervention on complications. Short-term and long-term outcomes were compared between the groups.
RESULTS
CTOD severe obstruction (CTOD grade 3) was an independent risk factor [odds ratio (OR) = 3.390, 95% confidence interval (CI): 1.340-8.570, P = 0.010] via multivariate analysis of short-term outcomes, while CROSS grade was not. In the CTOD-CROSS grade system, for the non-severe obstructive (CTOD 1-2 to CROSS 1-4) group, the complication rate of emergency interventions was significantly higher than that of non-emergency interventions (71.4% vs 41.8%, P = 0.040). The postoperative pneumonia rate was higher in the emergency intervention group than in the non-severe obstructive group (35.7% vs 8.9%, P = 0.020). However, CTOD grade was not an independent risk factor of overall survival and progression-free survival.
CONCLUSION
CTOD was useful in preoperative decision-making to avoid unnecessary emergency interventions and complications.
Risk of progression to high-grade intraepithelial neoplasia and gastric cancer: A multi-center prospective study in Anhui Province, China
Authors: Liu Ying-Ling , Liu Jie , Wang Ye-Tao 
Published: February 2025

BACKGROUND
Gastric cancer is one of the most common cancers worldwide, especially in East Asia.
AIM
To explore the clinical outcomes and progression-related factors of low-grade intraepithelial neoplasia (LGIN) in the gastric mucosa and provide valuable guidance for improving treatment efficacy.
METHODS
A total of 357 patients diagnosed with LGIN based on initial pathological examination in Anhui Provincial Hospital or three other medical consortium units between January 2022 and June 2024 were included. Among them, 296 patients were followed up with endoscopic and biopsy pathology. Logistic regression was utilized to analyze the relevant risk factors for LGIN progression in the gastric mucosa.
RESULTS
The distribution sites of LGIN among the 357 patients were as follows: Gastric antrum (54.6%), gastric cardia (24.1%), gastric angulus (8.7%), gastric body (4.8%), gastric fundus (4.8%), and multiple sites (3.1%). Additionally, of the 357 patients with LGIN, 112 (31.4%) developed ulceration and 59 (16.5%) experienced gastric polyps. Furthermore, 231 of the 357 (64.71%) patients with LGIN tested positive for Helicobacter pylori (H. pylori ) infection. The H. pylori infection rates of the patients with LGIN with accompanying atrophy, intestinal metaplasia, and gastric ulcer were 51.95%, 59.31%, and 28.57%, respectively. Multivariate logistic regression analysis showed that age ≥ 60 years [odds ratio (OR) = 3.063, 95% confidence interval (CI): 1.351-6.945, P = 0.007], H. pylori infection (OR = 3.560, 95%CI: 1.158-10.949, P = 0.027), multiple locations (OR = 10.136, 95%CI: 2.045-50.237, P = 0.005), lesion size ≥ 2 cm (OR = 3.921, 95%CI: 1.664-9.237, P = 0.002), and gastric ulcer (OR = 2.730, 95%CI: 1.197-6.223, P = 0.017) were predictive factors for LGIN progression.
CONCLUSION
LGIN progression is closely related to age, H. pylori positivity, multiple locations, lesion size ≥ 2 cm, and gastric ulcer. Thus, actively identifying these risk factors in patients with LGIN may have certain clinical significance in preventing further tumor progression.
Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma
Authors: Chen Xia , Liu Hai-Yan , Zhou Wu-Bi , Zhang Li-Li , Huang Jian , Bao Da-Wei 
Published: February 2025

BACKGROUND
Esophageal squamous-cell carcinoma (ESCC) is a highly aggressive cancer, predominantly affecting populations in Eastern Asia and parts of Africa. Its pathogenesis is influenced by both genetic and environmental factors. Despite recent therapeutic advances, survival rates remain dismal, underscoring an urgent need for novel therapeutic targets.
AIM
To investigate the role of hypoxia-inducible factor 1-alpha (HIF1A) in the progression of ESCC and its impact on the metabolic enzyme lactate dehydrogenase A (LDHA), which is crucial for the glycolytic pathway in hypoxic tumor environments.
METHODS
Utilizing transcriptomic data from multiple public databases, we analyzed differential gene expression and conducted gene ontology and transcription factor network analyses. The regulatory impact of HIF1A on LDHA was specifically examined through integrative analysis with HIF1A ChIP-seq data and confirmed via siRNA-mediated knockdown experiments in ESCC cell lines.
RESULTS
Our findings reveal a significant upregulation of HIF1A in ESCC tissues, associated with poor prognosis. HIF1A directly regulates LDHA, enhancing glycolysis under hypoxic conditions and contributing to tumor aggressiveness. Knockdown of HIF1A in cell lines not only reduced LDHA expression but also altered key pathways related to cell cycle and apoptosis.
CONCLUSION
The critical role of the HIF1A-LDHA axis in ESCC highlights its potential as a therapeutic target, underscoring the need for future clinical trials to validate the efficacy of HIF1A inhibitors in enhancing treatment outcomes.
Transmembrane protein 176B promotes epithelial-mesenchymal transition in colorectal cancer through inflammasome inhibition
Authors: Qian Wei , Xu Chong-Yi , Hong Wei , Li Zhe-Ming , Xu Dao-Gun 
Published: February 2025

BACKGROUND
Activation of the epithelial-mesenchymal transition (EMT), a pivotal process in tumor metastasis and evasion, as well as the NLRP3 inflammasome, both promote colorectal cancer (CRC) progression. Recent studies have shown that Transmembrane protein 176B (TMEM176B) regulates NLRP3 and promotes CRC malignant phenotypes.
AIM
To investigate the role of TMEM176B in modulating NLRP3 inflammasome and its implications on EMT and tumor progression in CRC.
METHODS
CRC in situ mouse and co-cultured cell models were established using CT26 cells, BALB/c mice, and primary cultured mouse natural killer (NK) cells. Short hairpin RNA knocked down TMEM176B and NLRP3 expression in CT26 cells. Fluorescence imaging, Terminal deoxynucleotidyl transferase dUTP nick end labeling assays, immunohistochemistry staining, flow cytometry, and molecular assays were used to investigate the effects of TMEM176B knockdown on the NLRP3 inflammasome in NK cells to assess tumor metastasis, apoptosis, and EMT indicators.
RESULTS
Silencing TMEM176B in CRC mice significantly reduced tumor metastasis, proliferation, and EMT, while activating apoptosis, NLRP3 inflammasome, and NK cell activity. Furthermore, silencing TMEM176B in co-cultured cell models inhibited cell migration and invasion, and promoted apoptosis. The interference of NLRP3 reversed these effects by modulating key proteins such as phosphorylated nuclear factor kappa B subunit 1 p65, matrix metallopeptidase 9, and transforming growth factor-β.
CONCLUSION
This study highlights the critical role of TMEM176B/NLRP3 in CRC progression and provides a basis for targeting this axis as a novel therapeutic approach to manage CRC progression and metastasis.
Significance of monitoring imatinib plasma concentration in second-line treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors
Authors: Li Hai-Tao , Du Yun-Yun , Huang Zhen , Li Jin-Jin , Zhang Jun 
Published: February 2025

BACKGROUND
For patients with advanced gastrointestinal stromal tumors (GISTs) carrying the c-kit exon 11 mutation, imatinib (IM) at a standard dosage of 400 mg per day is the preferred first-line treatment. In cases where treatment with IM fails, there is an urgent need for a more precise assessment method to determine whether to switch therapies or escalate the IM dosage. This approach will enhance clinical decision-making and optimize patient outcomes.
AIM
To investigate IM plasma concentration’s role in second-line treatment decisions for c-kit 11-mutated advanced GISTs post-IM failure.
METHODS
Patients with advanced GIST harboring c-kit 11 mutation who experienced failure with IM 400 mg per day as first-line treatment at our hospital were retrospectively analyzed. Patients were categorized into a low plasma (LP) concentration group (LP group, < 1100 ng/mL) and high plasma (HP) concentration group (HP group, ≥ 1100 ng/mL). Each group was further subdivided into Group A (dose-escalation group) and Group B (drug-switch group). Baseline characteristics were compared and Kaplan-Meier curves were used to analyze the survival of patients.
RESULTS
Seventy-five patients were included in the analysis. For the LP group (n = 28), Group A (n = 14) had longer overall survival (OS) than Group B (n = 14) (P = 0.02). No differences were observed between the two subgroups in disease control rate (DCR), objective response rate, and progression-free survival (PFS) (P > 0.05). For the HP group (n = 47), Group B (n = 18) had a higher DCR and longer PFS than Group A (n = 29) (P = 0.008 and P = 0.03, respectively). No difference in OS was observed between the two subgroups (P > 0.05).
CONCLUSION
Increasing IM dosage for c-kit 11-mutated advanced GISTs post-IM failure may prolong OS if plasma concentration is < 1100 ng/mL. Switching tyrosine kinase inhibitors may improve DCR and PFS if ≥ 1100 ng/mL.
Cystic artery embolism after transarterial chemoembolization for hepatocellular carcinoma: A case report and review of the literature
Authors: Chen Yi-Fan , Lin Zhen-Yi , Chen Lin-Tao , Zhang Yu , Du Zhao-Qing 
Published: February 2025

BACKGROUND
Acute cholecystitis due to unintended cystic artery embolism is an uncommon and mostly self-limiting complication after transarterial chemoembolization procedure for treatment of hepatocellular carcinoma. Usually, conservative management is sufficient for complete recovery of patients who develop this complication. If conservative treatment is ineffective, urgent surgical intervention may be required to prevent the progression of complications.
CASE SUMMARY
This article reports a rare and serious case of acute cholecystitis complicated by gallbladder necrosis and biliary peritonitis, which was initially treated conservatively but eventually necessitated emergency laparotomy. The patient initially presented with equivocal symptoms of fever and upper abdominal pain and distention, which worsened at the two weeks mark along with emergence of signs of peritonitis. This was managed by emergency laparotomy and cholecystostomy, allowing rapid symptom relief. The patient ultimately discharged and succumbed to advanced liver cancer 11 months after diagnosis.
CONCLUSION
After cholecystostomy, the patient showed symptom relief and was discharged, surviving 11 months post-stage IIIB liver cancer diagnosis.