bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-Evaluation as a Tool in Developing Environmental Responsibility
Authors: Pace Paul 
Published: June 2010

Self-Evaluation as a Tool in Developing Environmental ResponsibilityThe purpose of the paper is to share the findings of an action research project aimed at exploring the impact of transformative pedagogies on pre-service teachers following an environmental education programme (EEP), offered by the University of Malta. Assessment and evaluation practices of environmental education (EE) and education for sustainable education (ESD) programmes tend to cater just for knowledge content and skills, usually failing to target the development of attitudes and values that promote sustainable lifestyles. The EEP was specifically designed to target the development of pro-environmental values by actively involving students in their learning mainly and providing opportunities for reflection and self-evaluation. The paper analyses qualitative research data obtained from evaluation questionnaires about every study unit in the programme; reflective questionnaires drawing upon the students' reflective journals; a focus group interview and in depth one-to-one interviews with individual students. The paper provides students' evaluations about the course design and effectiveness that should provide insights for course developers and evaluators seeking to develop EE/ESD programmes that address individual needs through learner centred pedagogies.
Teachers' Perceptions on What Inclusion Needs
Authors: Bērziņa Ženija 
Published: June 2010

Teachers' Perceptions on What Inclusion NeedsA decade has passed since the equal right of all children to quality education regardless of their mental or physical abilities was declared by the Education Law (Izglītības likums, 1998). During that interlude, the Latvian educational system went through a period of tremendous change from total segregation of children with special needs in special schools to so-called "correction" classes in general schools, then to the special classes in general schools and finally to inclusion of special needs children in regular classrooms. Thus, the idea of inclusive education has been developed and implemented in various forms, which causes people to have a different understanding of what inclusive education means and impedes children with special needs from learning together with their peers in general classrooms. This article reflects on the findings of a qualitative study that was designed and conducted to investigate different perceptions of pre-school and primary school teachers on the preconditions for inclusive education.
Treatment of endometrial polyps: a systematic review
Authors: LIENG MARIT , ISTRE OLAV , QVIGSTAD ERIK 
Published: June 2010

AbstractBackground. Transcervical resection of endometrial polyps is usually performed in order to exclude atypic and/or malignant endometrial changes, to relieve abnormal uterine bleeding or to improve infertility. Objective. To systematically explore the rationale of transcervical polyp resection. Search strategy. Electronic searches of MEDLINE, EMBASE and The Cochrane Library. Selection criteria. Studies reporting the prevalence of premalignant and/or malignant tissue changes within endometrial polyps, as well as outcomes of endometrial polyp removal in terms of symptom relief and improved fertility were included. Main results. 46 studies met the criteria for inclusion (malignancy: 20 studies including 9,266 women, symptom relief: 15 studies including 1,034 women, infertility: 11 studies including 935 women). Most studies were uncontrolled retrospective case series. Only two randomized controlled trials were identified. The prevalence of premalignant and malignant tissue changes within endometrial polyps varied in the included studies, 0.2–23.8% and 0–12.9%, respectively. Postmenopausal symptomatic women appeared to have the highest risk of premalignant and malignant tissue changes. The effect of polypectomy on periodic blood loss appeared to be questionable, but all studies measuring the effect of polypectomy by general terms such as improved/not improved reported a favorable outcome (75–100% success rate). Polypectomy appears to have a favorable outcome in infertile women. Conclusions. The evidence which substantiates the removal of endometrial polyps is limited, and future research evaluating the outcome of this common procedure is required. Based on the available evidence, however, we provide recommendations for treatment of women with endometrial polyps.
18F-fluoroethylcholine uptake in arterial vessel walls and cardio vascular risk factors
Authors: Rominger A. , Saam T. , Wolpers S. , Nikolaou K. , Cumming P. , Reiser M. F. , Bartenstein P. , Hacker M. , Förster S. 
Published: June 2010

Summary
Aim: Fluorine-labelled choline derivatives were recently suggested as agents for visualizing vulnerable atherosclerotic plaques. We therefore aimed to evaluate the association between18F-fluoroethylcholine (FEC) uptake in the wall of large arteries, where calcification was also measured, with the presence of cardiovascular risk factors and occurrence of prior cardiovascular events. Patients, methods: Detailed clinical information, including common cardiovascular risk factors, was obtained retrospectively in 60 prostate cancer patients examined with whole-body FEC PETCT. In each patient, we calculated the mean blood pool-corrected SUV, as well as the mean target-to-background ratio (TBR), in addition to the sum of calcified plaques (CPsum) from six major vessels: ascending and descending aorta, aortic arch, abdominal aorta, and both iliac arteries. Results: As reported previously, the CPsum correlated significantly with cardiovascular risk factors, in contrast to mean SUV or TBR scores, which did not show any significance with the presence of cardiovascular risk factors. There was no correlation between CPsum, mean TBR or SUV, nor was there any significant association of CPsum, mean TBR or SUV with the prior occurrence of cardio- or cerebrovascular events. Conclusion: Contrary to a recent report, we found in our rather large cohort of elderly prostate cancer patients no significant association between FEC uptake in large vessels and atherosclerotic plaque burden, or the presence of cardiovascular risk factors. In line with prior reports on structural changes in vessels, increased calcified atherosclerotic plaque burden was strongly associated with the occurrence of common cardiovascular risk factors.
Mechanisms of IL-12 Synthesis by Human Dendritic Cells Treated with the Chemical Sensitizer NiSO4
Authors: Antonios Diane , Rousseau Philippe , Larangé Alexandre , Kerdine-Römer Saadia , Pallardy Marc 
Published: June 2010

Abstract
Allergic contact dermatitis, caused by metallic ions, is a T cell-mediated inflammatory skin disease. IL-12 is a 70-kDa heterodimeric protein composed of IL-12p40 and IL-12p35, playing a major role in the generation of allergen-specific T cell responses. Dendritic cells (DCs) are APCs involved in the induction of primary immune responses, as they possess the ability to stimulate naive T cells. In this study, we address the question whether the sensitizer nickel sulfate (NiSO4) itself or in synergy with other signals can induce the secretion of IL-12p70 in human monocyte-derived DCs (Mo-DCs). We found that IL-12p40 was produced by Mo-DC in response to NiSO4 stimulation. Addition of IFN-γ concomitantly to NiSO4 leads to IL-12p70 synthesis. NiSO4 treatment leads to the activation of MAPK, NF-κB pathways, and IFN regulatory factor 1 (IRF-1). We investigated the role of these signaling pathways in IL-12 production using known pharmacological inhibitors of MAPK and NF-κB pathways and RNA interference-mediated silencing of IRF-1. Our results showed that p38 MAPK, NF-κB, and IRF-1 were involved in IL-12p40 production induced by NiSO4. Moreover, IRF-1 silencing nearly totally abrogated IL-12p40 and IL-12p70 production provoked by NiSO4 and IFN-γ. In response to NiSO4, we observed that STAT-1 was phosphorylated on both serine and tyrosine residues and participated to NiSO4-induced IRF-1 activation. N-acetylcysteine abolished STAT-1 phosphorylation, suggesting that STAT-1 activation may be dependent on NiSO4-induced alteration of the redox status of the cell. These results indicate that p38 MAPK, NF-κB, and IRF-1 are activated by NiSO4 in Mo-DC and cooperate for IL-12 production.
TLR4-Mediated Sensing of Campylobacter jejuni by Dendritic Cells Is Determined by Sialylation
Authors: Kuijf Mark L. , Samsom Janneke N. , van Rijs Wouter , Bax Marieke , Huizinga Ruth , Heikema Astrid P. , van Doorn Pieter A. , van Belkum Alex , van Kooyk Yvette , Burgers Peter C. , Luider Theo M. , Endtz Hubert P. , Nieuwenhuis Edward E. S. , Jacobs Bart C. 
Published: June 2010

Abstract
In Guillain-Barré syndrome (GBS), ganglioside mimicry of Campylobacter jejuni lipo-oligosaccharide (LOS) drives the production of cross-reactive Abs to peripheral nerve gangliosides. We determined whether sialic acid residues in C. jejuni LOS modulate dendritic cell (DC) activation and subsequent B cell proliferation as a possible mechanism for the aberrant humoral immune response in GBS. Highly purified sialylated LOS of C. jejuni isolates from three GBS patients induced human DC maturation and secretion of inflammatory cytokines that were inhibited by anti-TLR4 neutralizing Abs. The extent of TLR4 signaling and DC activation was greater with LOS of the wild type isolates than with nonsialylated LOS of the corresponding sialyltransferase gene knockout (cst-II mutant) strains, indicating that sialylation boosts the DC response to C. jejuni LOS. Supernatants of LOS-activated DCs induced B cell proliferation after cross-linking of surface Igs in the absence of T cells. Lower B cell proliferation indices were found with DC supernatants after DC stimulation with cst-II mutant or neuraminidase desialylated LOS. This study showed that sialylation of C. jejuni LOS enhances human DC activation and subsequent B cell proliferation, which may contribute to the development of cross-reactive anti-ganglioside Abs found in GBS patients following C. jejuni infection.
Chronic Rejection Triggers the Development of an Aggressive Intragraft Immune Response through Recapitulation of Lymphoid Organogenesis
Authors: Thaunat Olivier , Patey Natacha , Caligiuri Giuseppina , Gautreau Chantal , Mamani-Matsuda Maria , Mekki Yahia , Dieu-Nosjean Marie-Caroline , Eberl Gérard , Ecochard René , Michel Jean-Baptiste , Graff-Dubois Stéphanie , Nicoletti Antonino 
Published: June 2010

Abstract
The unwarranted persistence of the immunoinflammatory process turns this critical component of the body’s natural defenses into a destructive mechanism, which is involved in a wide range of diseases, including chronic rejection. Performing a comprehensive analysis of human kidney grafts explanted because of terminal chronic rejection, we observed that the inflammatory infiltrate becomes organized into an ectopic lymphoid tissue, which harbors the maturation of a local humoral immune response. Interestingly, intragraft humoral immune response appeared uncoupled from the systemic response because the repertoires of locally produced and circulating alloantibodies only minimally overlapped. The organization of the immune effectors within adult human inflamed tissues recapitulates the biological program recently identified in murine embryos during the ontogeny of secondary lymphoid organs. When this recapitulation was incomplete, intragraft B cell maturation was impeded, limiting the aggressiveness of the local humoral response. Identification of the molecular checkpoints critical for completion of the lymphoid neogenesis program should help develop innovative therapeutic strategies to fight chronic inflammation.
Parent/Child Training to Increase Preteens' Calcium, Physical Activity, and Bone Density: A Controlled Trial
Authors: Hovell Melbourne F. , Nichols Jeanne F. , Irvin Veronica L. , Schmitz Katharine E. , Rock Cheryl L. , Hofstetter C. Richard , Keating Kristen , Stark Lori J. 
Published: June 2010

Purpose. To test effects of parent/child training designed to increase calcium intake, bone-loading physical activity (PA), and bone density. Design. Two-group randomized controlled trial. Setting. Family-based intervention delivered at research center. Subjects. 117 healthy children aged 10–13 years (58.1% female, 42.7% Hispanic, 40.2% White). Ninety-seven percent of participants had at least one parent graduate from high school and 37.2 % had at least one parent graduate from a 4-year university. Intervention. Children and parents were randomly assigned to diet and exercise (experimental) or injury prevention (control) interventions. Children were taught in eight weekly classes how to engage in bone-loading PA and eat calcium-rich foods or avoid injuries. Parents were taught behavior management techniques to modify children's behaviors. Measures. Measures at baseline and at 3, 9, and 12 months included 24-hour diet and PA recalls, and bone mineral density (BMD) by dual-energy x-ray absorptiometry. Analysis. Analysis of variance and generalized estimating equations (GEE) assessed group by time differences. Comparisons were conducted separately for boys and girls. Results. For boys, cross-sectional differences between experimental and control groups were achieved for 3- and 9-month calcium intake (1352 vs. 1052 mg/day, 1298 vs. 970 mg/day, p < .05). For girls, marginal cross-sectional differences were achieved for high-impact PA at 12 months (p < .10). For calcium intake, a significant group by time interaction was observed from pretest to posttest for the full sample (p = .008) and for girls (p = .006) but not for boys. No significant group by time differences in calcium were observed across the follow-up period. No group by time differences were observed for high-impact PA. Among boys, longitudinal group by time differences reached significance for total hip BMD (p = .045) and femoral neck BMD (p = .033), even after adjusting for skeletal growth. Similar differential increases were observed among boys for bone mineral content (BMC) at the hip (p = .068) and total body (p = .054) regions. No significant group by time interaction effects were observed for girls at any bone site for BMD. For BMC, control girls showed a significant increase (p = .03) in spine BMC compared to intervention girls. Conclusion. This study demonstrated that parent/preteen training can increase calcium intake and attenuate the decline in high-impact PA. Results suggest that more powerful interventions are needed to increase activity levels and maximize bone mineral accrual during preadolescent years.
Production of Xylenes from Toluene and 1,2,4‐Trimethylbenzene over ZSM‐5 and Mordenite Catalysts in a Fluidized‐Bed Reactor
Authors: Aitani A. M. , Ali A. M. , Waziri S. M. , Al‐Khattaf S. 
Published: June 2010

AbstractThe production of various xylenes from toluene, heavy aromatics such as 1,2,4‐trimethylbenzene (1,2,4‐TMB) and their mixture was investigated over H‐ZSM‐5 (H‐Z), H‐mordenite (H‐M) and a dual zeolitic catalyst comprising ZSM‐5 and mordenite (H‐ZM). The experiments were conducted in a riser‐simulator reactor under different operating conditions to study the effect of temperature, reaction time and feed composition on conversion and product yields. At 400 °C, the conversion of toluene over the three catalysts yielded mainly benzene and xylenes with maximum conversion at 25 % and a xylene yield of 12.5 wt % over the H‐M catalyst. The transformation of 1,2,4‐TMB doubled the conversion level and xylene yield and suppressed benzene formation. However, a considerable portion of the 1,2,4‐TMB feed was isomerized into 1,2,3‐TMB and 1,3,5‐TMB accompanied by the formation of tetramethylbenzenes (TeMBs). The conversion of an equimolar mixture of toluene and 1,2,4‐TMB over the three catalysts resulted in higher toluene conversion and double xylene yield in comparison with 1,2,4‐TMB alone. The advantage of using a dual zeolitic catalyst was observed at an equimolar feed of toluene and 1,2,4‐TMB, exhibiting maximum toluene conversion, higher xylene yield and the formation of lower levels of undesirable products.
ChemInform Abstract: Total Synthesis of (‐)‐Dysiherbaine, a Novel Neuroexcitotoxic Amino Acid.
Authors: Sasaki Makoto , Koike Tatsuki , Sakai Ryuichi , Tachibana Kazuo 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Formal Synthesis of Reserpine: Hydrindane Approach to the Woodward′s Ring‐E Precursor.
Authors: Mehta Goverdhan , Reddy D. Srinivasa 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Pericyclic Cascade to the Stereocontrolled Synthesis of 9‐cis‐Retinoids.
Authors: Iglesias Beatriz , Torrado Alicia , de Lera Angel R. , Lopez Susana 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Some Alkaloids Using the Allyl Derivatives of Boron
Authors: Bubnov Yu. N. , Klimkina E. V. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Conversion of Acylsilanes to Esters Mediated by Iron(III) and Nitrate Ions.
Authors: Patrocinio Amauri F. , Moran Paulo J. S. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Syntheses and Ring‐Opening Reactions of trans‐ and cis‐Oxazoline‐5‐carboxylates.
Authors: Lee Sang‐Hyeup , Yoon Juyoung , Nakamura Kensuke , Lee Yoon‐Sik 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Thiopyran Route to Polypropionates: Aldol Diastereoselectivity of Linear and Two‐Directional Iterative Homologations.
Authors: Ward Dale E. , Guo Cheng , Sasmal Pradip K. , Man Chuk C. , Sales Marcelo 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Affinity Labeling at the 4‐Hydroxyl Group of N‐Acetylglucosamine and N‐Acetylgalactosamine.
Authors: Moule Christie J. , Clements Peter R. , Hopwood John J. , Crisp Geoffrey T. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Catalysis: A Ligand′s Eye View
Authors: Handy Scott T. 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Heat‐Accumulating Properties of Melts
Authors: Gasanealiev A. M. , Gamataeva B. Yu 
Published: June 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Fermentative Herstellung von L‐Lysin‐L‐lactat mittels Fraktionierungssäften aus der Grünen Bioraffinerie
Authors: Leiß S. , Kamm B. , Venus J. 
Published: June 2010

AbstractMilchsäure ist eine Plattformchemikalie für eine zukünftig biobasierte Stoffwirtschaft. Aminiumlactate fungieren als Intermediate für die Herstellung von Milchsäurefolgeprodukten wie Dilactid. Im Artikel wird gezeigt, dass nach Separation von Proteinen aus Luzernepresssaft der Überstand als Fermentationsmedium für die Herstellung des Aminiumlactats L‐Lysin‐L‐lactat eingesetzt werden kann.
Automatisiertes Prozessieren von hochviskosen Flüssigkeiten im Labor
Authors: Müller A. , Mathes V. , Stumpf M. , Hürtgen D. , Reiss M. , Hauck P. , Troppmann U. , Laubender M. , Schröder J. , Kulzer K. 
Published: June 2010

AbstractVollautomatisierte Hochdurchsatzsysteme in F&E‐Labors helfen Produktionsprozesse zu optimieren. Breite Parameterräume können experimentell erfasst werden. Die Bestandteile von Produkten aus den Bereichen Kosmetik, Nahrungsmittel, Lacke und Farben oder Agrochemie sind häufig hochviskose Flüssigkeiten, Gele oder Pasten. Die rheologischen Eigenschaften dieser Medien stellen allerdings eine besondere Herausforderung für die automatische Prozessierung dar.
E,E‐Bis(styryl)sulfones—Synthons for a new class of bis(heterocycles)
Authors: Padmavathi Venkatapuram , Mohan Reddy Boggu Jagan , Mahesh Konda , Thriveni Pinnu , Padmaja Adivireddy 
Published: June 2010

Abstract
magnified image A new class of bis heterocycles having two different heterocyclic rings viz., pyrroles in combination with pyrazolines and isoxazolines were synthesized. All the compounds were characterized by elemental and spectral analysis. J. Heterocyclic Chem., (2010).
An efficient one‐pot synthesis of N‐(1,3‐diphenyl‐1H‐pyrazol‐ 5‐yl)amides
Authors: Su Wei‐Nien , Lin Tsung‐Ping , Cheng Kaung‐Min , Sung Kuan‐Chin , Lin Shao‐Kai , Wong Fung Fuh 
Published: June 2010

Abstractmagnified image A “one‐pot” method for the synthesis of N‐(1,3‐diphenyl‐1H‐pyrazol‐5‐yl)amides was developed by cyclization of benzoylacetonitrile (1) and phenylhydrazine in neat condition followed by acylation. The corresponding N‐(1,3‐diphenyl‐1H‐pyrazol‐5‐yl)amides were provided in good to excellent yields (70–90%). The significant advantages of the new synthetic method are excellent yields and simple work‐up procedure without isolation and purification of intermediary 5‐amino‐1,3‐diphenyl pyrazol (2). J. Heterocyclic Chem., (2010).