bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Features, Biological Pathways, and Protein Interaction Networks of Addiction‐Related Genes
Authors: Sun Jingchun , Zhao Zhongming 
Published: May 2010

AbstractAddictions are chronic and common brain disorders affected by many genetic, environmental, and behavioral factors. Recent genome‐wide linkage and association studies have revealed several promising genomic regions and multiple genes relating to addictions. To explore the underlying biological processes in the development of addictions, we used 62 genes recently reviewed by Li and Burmeister (2009) as representative addiction‐related genes, and then we investigated their features in gene function, pathways, and protein interaction networks. We performed enrichment tests of their Gene Ontology (GO) annotations and of their pathways in the Ingenuity Pathways Analysis (IPA) system. The tests revealed that these addiction‐related genes were highly enriched in neurodevelopment‐related processes. Interestingly, we found circadian rhythm signaling in one of the enriched pathways. Moreover, these addiction‐related genes tended to have higher connectivity and shorter characteristic shortest‐path distances compared to control genes in the protein–protein interaction (PPI) network. This investigation is the first of such kind in addiction studies, and it is useful for further addiction candidate‐gene prioritization and verification, thus helping us to better understand molecular mechanisms of addictions.
Gene Network Analysis during Early Infection of Human Coronary Artery Smooth Muscle Cells by Trypanosoma cruzi and Its gp83 Ligand
Authors: Nde Pius N. , Johnson Candice A. , Pratap Siddharth , Cardenas Tatiana C. , Kleshchenko Yuliya Y. , Furtak Vyacheslav A. , Simmons Kaneatra J. , Lima Maria F. , Villalta Fernando 
Published: May 2010

AbstractTrypanosoma cruzi, the causative agent of Chagas' disease, infects heart and muscle cells leading to cardiac arrest, followed by death. The genetic architectures in the early T. cruzi infection process of human cells are unknown. To understand the genetic architectures of the early invasion process of T. cruzi, we conducted gene transcription microarray analysis, followed by gene network construction of the host cell response in primary human coronary artery smooth muscle (HCASM) cells infected with T. cruzi or exposed to T. cruzi gp83, a ligand used by the trypanosome to bind host cells. Using seven RT‐PCR verified up‐regulated genes (FOSB, ATF5, INPP1, CCND2, THBS1, LAMC1, and APLP2) as the seed for network construction, we built an interaction network of the early T. cruzi infection process containing 165 genes, connected by 598 biological interactions. This interactome network is centered on the BCL6 gene as a hub. Silencing the expression of two seed genes (THBS1 and LAMC1) by RNAi reduced T. cruzi infection. Overall, our results elucidate the significant and complex process involved in T. cruzi infection of HCASM cells at the transcriptome level. This is the first elucidation into the interactome network in human cells caused by T. cruzi and its gp83 ligand.
Analysis of Multitag Pyrosequence Data from Human Cervical Lavage Samples
Authors: Naqvi Ammar , Rangwala Huzefa , Spear Greg , Gillevet Patrick 
Published: May 2010

AbstractWe have been using the Roche GS‐FLX sequencing platform to produce tens of thousands of sequencing reads from samples of both bacterial communities (microbiome) and fungal communities (mycobiome) of stool, gut mucosa, vaginal washes, and oral washes from a large number of subjects. This vast volume of data from diverse sources has necessitated the development of an analysis pipeline in order to systematically and rapidly identify the taxa within the samples and to correlate the sample data with clinical and environmental features. Specifically, we have developed automated analytical tools for data tracking, taxonomical analysis, and feature clustering of bacteria in the human microbiome and demonstrate the pipeline using Cervical Vaginal Lavage (CVL) samples. This analysis pipeline will not only provide insight to our specific CVL dataset, but is applicable to other microbiome samples and will ultimately broaden our understanding of how the microbiome influences human health.
Quantitative Assessment of the Human Gut Microbiome Using Multitag Pyrosequencing
Authors: Gillevet Patrick , Sikaroodi Masoumeh , Keshavarzian Ali , Mutlu Ece A. 
Published: May 2010

AbstractRecent advances in molecular techniques have now made it possible to interrogate the human microbiome in depth to better understand the interactions with the host organism and its role in diseases. We now report the utility of Length Heterogeneity Polymerase Chain Reaction (LH‐PCR) to survey samples and a proprietary Multitagged Pyrosequencing (MTPS) methodology to interrogate the gut microbiome in healthy and disease states. We present an overview of our studies demonstrating the application of these molecular‐biology techniques to an example disease state such as Inflammatory Bowel Disease (IBD). The findings show that there is a core mucosal bacterial microbiome (i.e., a mucosal biofilm) that is distinct from the luminal microbiome in health, and that the mucosal microbiome appears to be dysbiotic in IBD. We propose that the mucosal microbiome forms a synergistic and stable interaction with the host immune system, while the lumen microbiome varies based on diet or other environmental factors. We define this composite ecosystem of the human microbiome and human host as the Human Metabiome.
A Genome‐Scale Metabolic Model of Cryptosporidium hominis
Authors: Vanee Niti , Roberts Seth B. , Fong Stephen S. , Manque Patricio , Buck Gregory A. 
Published: May 2010

AbstractThe apicomplexan Cryptosporidium is a protozoan parasite of humans and other mammals. Cryptosporidium species cause acute gastroenteritis and diarrheal disease in healthy humans and animals, and cause life‐threatening infection in immunocompromised individuals such as people with AIDS. The parasite has a one‐host life cycle and commonly invades intestinal epithelial cells. The current genome annotation of C. hominis, the most serious human pathogen, predicts 3884 genes of which ca. 1581 have predicted functional annotations. Using a combination of bioinformatics analysis, biochemical evidence, and high‐throughput data, we have constructed a genome‐scale metabolic model of C. hominis. The model is comprised of 213 gene‐associated enzymes involved in 540 reactions among the major metabolic pathways and provides a link between the genotype and the phenotype of the organism, making it possible to study and predict behavior based upon genome content. This model was also used to analyze the two life stages of the parasite by integrating the stage‐specific proteomic data for oocyst and sporozoite stages. Overall, this model provides a computational framework to systematically study and analyze various functional behaviors of C. hominis with respect to its life cycle and pathogenicity.
Network‐Based Modeling of the Human Gut Microbiome
Authors: Naqvi Ammar , Rangwala Huzefa , Keshavarzian Ali , Gillevet Patrick 
Published: May 2010

AbstractIn this article, we used a network‐based approach to characterize the microflora abundance in colonic mucosal samples and correlate potential interactions between the identified species with respect to the healthy and diseased states. We analyzed the modelled network by computing several local and global network statistics, identified recurring patterns or motifs, fit the network models to a family of well‐studied graph models. This study has demonstrated, for the first time, an approach that differentiated the gut microbiota in alcoholic subjects and healthy subjects using topological network analysis of the gut microbiome.
Nitrooxymethyl‐Substituted Analogues of Rofecoxib: Synthesis and Pharmacological Characterization
Authors: Boschi Donatella , Cena Clara , Di Stilo Antonella , Rolando Barbara , Manzini Paola , Fruttero Roberta , Gasco Alberto 
Published: May 2010

AbstractNitrooxymethyl‐substituted derivatives of Rofecoxib were synthesized and tested for their cyclooxygenase (COX)‐inhibiting activity in whole human blood, vasodilator potency on rat aorta strips, and for their capacity of inhibiting platelet aggregation of human platelet‐rich plasma. The results show that their potency and selectivity in inhibiting COX isoforms, as well as their anti‐aggregatory properties, are closely dependent on the position at which the NO‐donor nitrooxymethyl function is introduced into the Rofecoxib scaffold. All the products were capable of dilating rat aorta strips precontracted with phenylephrine in a dose‐dependent manner, through a cGMP‐dependent mechanism. Compound10emerged as a quite potent COX‐2‐selective inhibitor endowed with good vasodilator activity. Interestingly, compound19behaved as a potent selective COX‐1 inhibitor, and displayed good vasodilator and anti‐aggregatory properties. The hydroxymethyl derivatives, potential metabolites of the nitrooxymethyl analogues, were similarly studied for a comparison.
Cellular Automata Modeling of FASL‐Initiated Apoptosis
Authors: Apte Advait , Bonchev Danail , Fong Stephen 
Published: May 2010

AbstractTwo strategies for fighting cancer by modulating FASL‐induced apoptosis were modeled by 2D‐cellular automata. Our models predict that cancer cells can be killed by maximizing the apoptosis via joint suppression of FLIP and IAP inhibitors by siRNA and SMAC proteins, respectively. It was also predicted that the presumed feedback loop CASP3→CASP9→|IAP in the intrinsic pathway accelerates the apoptosis, but does not change significantly the concentration of DFF40, the protein that decomposes DNA. The alternative strategy of preventing the killing of the immune system's T‐cells, via minimizing their tumor‐induced FAS‐L apoptosis by overexpression of FLIP and IAP, was also shown to be promising with a predicted considerable synergy action of the two inhibitors. Dual suppression or overexpression of apoptosis inhibitors emerges thus as promising approach in the fight against cancer. Our modeling has also brought some light on the process of turning type‐I cells into type‐II ones, which emerges as compensatory mechanism in case of damaged or silenced FASL pathway by preserving about the same self‐death level at only 10–12% lower performance rate.
How to Produce a Chemical Defense: Structural Elucidation and Anatomical Distribution of Aplysioviolin and Phycoerythrobilin in the Sea Hare Aplysia californica
Authors: Kamio Michiya , Nguyen Linh , Yaldiz Seymanur , Derby Charles D. 
Published: May 2010

AbstractWe previously used bioassay‐guided fractionation to identify phycoerythrobilin (1) and its monomethyl ester, aplysioviolin (2), as components in the ink secretion of a marine gastropod, the sea hare Aplysia californica, that act as chemical deterrents against predatory blue crabs. This was the first report of 1 as a natural product. Compound 2 was previously reported as a natural product from three species of Aplysia (A. fasciata, A. dactylomela, and A. parvula), but the reported structure and composition of stereoisomers of 2 are different among these species. Sea hares are thought to produce 2 from phycoerythrin, a photosynthetic pigment in their red‐algal diet composed of a phycobiliprotein covalently linked to the chromophore 1, by cleavage of the covalent bond and methylation of 1, but neither the sequence nor the anatomical location of the cleavage and methylation is known. In this study, we clarify the structure of 1 and 2 in ink secretion of A. californica, and describe the distribution of 1 and 2 in the tissues of sea hares. We conclude that cleavage of the covalent bond in phycoerythrin occurs first, forming 1 in the digestive gland, followed by methylation of 1 to yield 2 in the ink gland.
Antimicrobial and Cytotoxic Activities of Synthetically Derived Tambjamines C and E – J, BE‐18591, and a Related Alkaloid from the Marine Bacterium Pseudoalteromonas tunicata
Authors: Pinkerton David M. , Banwell Martin G. , Garson Mary J. , Kumar Naresh , de Moraes Manoel Odorico , Cavalcanti Bruno C. , Barros Francisco W. A. , Pessoa Cláudia 
Published: May 2010

AbstractIn the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1–9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non‐selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis‐inducing effects.
ChemInform Abstract: Asymmetric Synthesis of α‐Substituted β‐Nitrophosphonic Acids by Phospha‐Analogous Michael Addition to Aromatic Nitroalkenes.
Authors: Enders Dieter , Tedeschi Livio , Bats Jan Willem 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,3‐Dipolar Cycloadditions. Part 119. A Rearrangement of 3‐Pyrazolines as a Missing Link.
Authors: Finke Juergen A. , Huisgen Rolf , Temme Robert 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Trihalomethyl Derivatives of Benzimidazole, Benzotriazole and Indazole.
Authors: Yagupolskii Lev M. , Fedyuk Dmitrij V. , Petko Kirill I. , Troitskaya Valeriya I. , Rudyk Valentina I. , Rudyuk Vitalij V. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Coupling of Aryl Halides in the Ionic Liquid [bmim]PF6.
Authors: Howarth Joshua , James Paraic , Dai Jifeng 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Comprehensive Reinvestigation of the Reaction of D‐Aldoses with Meldrum′s Acid Yielding Mainly Chain Extended 3,6‐Anhydro‐2‐deoxy‐aldono‐1,4‐lactones.
Authors: Koell Peter , Wernicke Angelika , Kovacs Jozsef , Luetzen Arne 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Excited State Processes at Sensitized Nanocrystalline Thin Film Semiconductor Interfaces
Authors: Kelly Craig A. , Meyer Gerald J. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Generation of Bases and Anions from Inorganic and Organometallic Photoinitiators
Authors: Kutal Charles 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase Diagram Studies in the System Tl2O3—BaO—CaO—CuO—Ag.
Authors: Majewski Peter J. , Jalowicki Arthur , Kaesche Stefanie , Aldinger Fritz 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oxidation of Hydroquinones and Hydroquinone Monomethyl Ethers to Quinones with tert‐Butyl Hydroperoxide and Catalytic Amounts of Ceric Ammonium Nitrate (CAN).
Authors: Krohn Karsten , Vitz Juergen 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Angular Triquinanes from 1‐Alkynylbicyclo[3.2.0]hept‐2‐en‐7‐ones. A Tandem Alkoxy‐Cope Ring Expansion/Transannular Ring Closure Reaction.
Authors: Verma Sharad K. , Fleischer Everly B. , Moore Harold W. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Some Potential Antibacterial Pyrazoles and Pyrazolones.
Authors: Jain Rajeev , Padmaja P. , Bhadauria Jyoti , Tomar Sandeep 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Pseudomycin C′ (Ib) via a Novel Acid Promoted Side‐Chain Deacylation of Pseudomycin A (Ia).
Authors: Rodriguez Michael J. , Belvo Matthew , Morris Robert , Zeckner Douglas J. , Current William L. , Sachs Roberta K. , Zweifel Mark J. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stable Pyrano[2,3‐b]quinoxalines and Pyrano[2,3‐g]pteridines Related to Molybdopterin.
Authors: Bradshaw Ben , Collison David , Garner C. David , Joule John A. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: GaCl3‐Promoted Addition Reactions of Carbon Nucleophiles to Alkyne
Authors: Kido Yoshiyuki , Arisawa Mieko , Yamaguchi Masahiko 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure, and Properties of Carbon Encapsulated Metal Nanoparticles
Authors: Mchenry Michael E. , Subramoney Shekhar 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Transient Kinetics in Heterogeneous Catalysis by Metals
Authors: Frennet A. , Hubert C. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Question of exo vs. endo Cyclization. A Joint Experimental and ab initio Study on the Stereoselective Synthesis of Tetrahydrofurans and Tetrahydropyrans via Seleniranium Ions.
Authors: Gruttadauria Michelangelo , Lo Meo Paolo , Noto Renato 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: “Inverse‐Electron‐Demand” Diels—Alder Reactions of (E)‐3‐Diazenylbut‐2‐enes in Water.
Authors: Attanasi Orazio A. , De Crescentini Lucia , Filippone Paolino , Fringuelli Francesco , Mantellini Fabio , Matteucci Mizio , Piermatti Oriana , Pizzo Ferdinando 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New 3‐[4‐(Aryl)piperazin‐1‐yl]‐1‐(benzo[b]thiophen‐3‐yl)propane Derivatives (V) with Dual Action at 5‐HT1A Serotonin Receptors and Serotonin Transporter as a New Class of Antidepressants.
Authors: Monge Antonio , et al. et al. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of (.+‐.)‐Puraquinonic Acid: An Inducer of Cell Differentiation.
Authors: Clive Derrick L. J. , Sannigrahi Mousumi , Hisaindee Soleiman 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Growth, Morphology, Interfacial Effects and Catalytic Properties of Au on TiO2
Authors: Cosandey F. , Madey T. E. 
Published: May 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.