bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating microRNA profile of long‐lived Okinawans identifies novel potential targets for optimizing lifespan and health span
Authors: Noureddine Sarah , Schneider Augusto , Strader Sydney , Zhu Xiang , Dhahbi Joseph , Allsopp Richard , Willcox D. Craig , Donlon Timothy A. , Shimabukuro Michio , Higa Moritake , Suzuki Makoto , Torigoe Trevor , Ashiqueali Sarah , Yadav Hariom , Willcox Bradley J. , Masternak Michal M. 
Published: May 2024

AbstractNonagenarians and centenarians serve as successful examples of aging and extended longevity, showcasing robust regulation of biological mechanisms and homeostasis. Given that human longevity is a complex field of study that navigates molecular and biological mechanisms influencing aging, we hypothesized that microRNAs, a class of small noncoding RNAs implicated in regulating gene expression at the post‐transcriptional level, are differentially regulated in the circulatory system of young, middle‐aged, and nonagenarian individuals. We sequenced circulating microRNAs in Okinawan males and females <40, 50–80, and >90 years of age accounting for FOXO3 genetic variations of single nucleotide polymorphism (SNP) rs2802292 (TT ‐ common vs. GT ‐ longevity) and validated the findings through RT‐qPCR. We report five microRNAs exclusively upregulated in both male and female nonagenarians with the longevity genotype, play predictive functional roles in TGF‐β, FoxO, AMPK, Pi3K‐Akt, and MAPK signaling pathways. Our findings suggest that these microRNAs upregulated in nonagenarians may provide novel insight into enhanced lifespan and health span. This discovery warrants further exploration into their roles in human aging and longevity.
European survey showed wide variations in diagnostic procedures and management strategies for metabolic bone disease of prematurity in 22 countries
Authors: Brado Luise , Matheisl Daniel , Mildenberger Eva , Fuchs Hans , Klotz Daniel , Kidszun André 
Published: May 2024

AbstractAimThe aim of this study was to evaluate the clinical relevance, diagnostic procedures and treatment strategies for metabolic bone disease in preterm infants across Europe.MethodsAn e‐survey was distributed by email to 545 neonatal units in 38 European countries between July and October 2021. The protocol was based on the Checklist for Reporting Results of Internet E‐Surveys.ResultsIn total, 76 neonatal units (14%) from 22 European countries (58%) completed the e‐survey. In the 12 months prior to the survey, 29% of 76 units reported at least one symptomatic case of fracture associated with metabolic bone disease of prematurity, and 18% of 76 units reported at least one case of craniofacial deformity. Most centres followed local guidelines for diagnosis (77% of 73 units) and treatment (63% of 72 units). Alkaline phosphatase was the blood marker most used for treatment indication (81% of 72 units), and phosphate supplementation was the treatment most used (82% of 71 units).ConclusionMetabolic bone disease of prematurity remains clinically relevant. Wide variations in diagnostic procedures and management strategies were observed in European neonatal units. Evidence‐based consensus guidelines appear urgently needed to reduce the number of symptomatic cases.
Early impact assessment of the paninvasive polyphagous shot hole borer beetle on commercial pear production
Authors: Neethling Emma C. , Engelbrecht Karyn , Roets Francois , Crous Casparus J. 
Published: May 2024

AbstractThe polyphagous shot hole borer (PSHB) beetle, Euwallacea fornicatus (Eichhoff) (Coleoptera: Curculionidae, Scolytinae), and its phytopathogenic fungal symbiont (Fusarium euwallaceae Freeman et al.) threaten commercial and urban tree species worldwide. This pest–fungus complex has been newly discovered in the commercial deciduous fruit industry (Western Cape, South Africa), where its effect is still unknown. This study explored the impact of PSHB infestation on fruit quality and plant water‐use efficiency (WUE) – as indicated by carbon and nitrogen stable isotope ratios – of commercially cultivated Packham's Triumph pear trees within the first year of invasion, as well as changes in phenotypic plasticity (trait expression range). The impact of PSHB infestation is currently most evident in fruit quality traits, with a clear distinction between the control and most densely attacked tree categories. Fruit and leaf traits showed high variation and a significant change in phenotypic plasticity. Increased PSHB attack density was associated with smaller, duller‐toned, sweeter fruit at the time of harvest and data tended towards reduced plant WUE. Producers can expect significant variation in fruit quality and plant WUE even in hosts without branch dieback, visible plant stress or extensive beetle breeding, especially in orchards where infestations persist beyond the first year. These findings necessitate additional research to describe the long‐term impact, examine the threat to other deciduous fruit crops and cultivars and assess the need for adapted management or harvesting methods.
Trends in preterm birth in women living with HIV in Switzerland over the last three decades: A multicentric, prospective, cohort study
Authors: Lumbreras Areta Marina , Migliorelli Falcone Federico E. , Rudin Christoph , Kahlert Christian R. , Paioni Paolo , Baumann Marc U. , Darling Katharine , Polli Christian , Martinez de Tejada Begoña 
Published: May 2024

AbstractBackgroundHIV infection and its management during pregnancy to reduce perinatal transmission has been associated with preterm birth (PTB). This management has drastically changed. We aimed to evaluate changes in rates of PTB over 34 years in women living with HIV (WLWH) in Switzerland, and to identify factors and interventions associated with these changes.MethodsWe analysed data from 1238 singleton pregnancies, prospectively collected by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and the Swiss HIV Cohort Study (SHCS) between 1986 and 2020. Rates of PTB in this cohort were compared with that of the general Swiss population for three time periods according to changing treatment strategies recommended at the time. We evaluated the association of PTB with sociodemographic, HIV infection and obstetric variables in uni‐ and multivariate logistic regression.ResultsRate of PTB in WLWH was highest prior to 2010 (mean 20.4%), and progressively decreased since then (mean 11.3%), but always remained higher than in the general population (5%). Older maternal age, lower CD4 count and detectable viraemia at third trimester (T3), drug consumption and mode of delivery were all significantly associated with both PTB and period of study in univariate analysis. There was no association between PTB and type of antiretroviral regimen. No difference was found in the rate of spontaneous labor between PTB and term delivery groups. Only higher CD4 count at T3 and vaginal delivery were significantly associated with a decrease in PTB over time in multivariate analysis.ConclusionsPreterm birth in WLWH in Switzerland has drastically decreased over the last three decades, but remains twice the rate of that in the general population. Improved viral control and changes in mode of delivery (vaginal birth recommended if viral loads are low near birth) have led to this progress.
Program logic of a service collaboration to support parents with intellectual disability
Authors: Doery Elizabeth Jane , Varcoe Jay , Benstead Michelle , Ghayour‐Minaie Matin , Sheils Rebecca , Kavanagh Siobhan , Little Keriann , Pert Allie , Toumbourou John W. 
Published: May 2024

AbstractBackgroundThis article describes the Steps to Confident Parenting (SCP) program, developed by an Australian family service consortium. The SCP integrates home‐based and case‐management services to enhance the skills of parents with a diagnosed or suspected intellectual disability/cognitive impairment and to prevent child protection interventions.Method‘Program explication’ methodology documented the components/activities, and underpinning evidence for this practitioner designed service through interviews with nine agency staff. A literature review evaluated evidence for the implicit program benefit theory.Results and ConclusionThe SCP comprised five logically consistent components—Targeted Referral, Assessments, Initial Consultation, Program Delivery, Closure and Follow‐up. Components generally had ‘some’ supportive evidence, however there was a ‘lack of’ evidence for Closure and Follow‐up. In the context of a partnership seeking to build the evidence for the SCP, it was recommended that a protocol for a randomised trial evaluation with longer term follow‐up be drafted by the consortia.
Promoting solidarity based collective action through increasing hope using nonviolent communication intervention
Authors: Avichail Tamar , Ruhrman Anat , Eick Noa Cohen , Estlein Roi , Halperin Eran 
Published: May 2024

AbstractThe present study explores the impact of nonviolent communication (NVC) intervention on advantaged group members’ actual participation in collective action on behalf of disadvantaged outgroups, also known as solidarity‐based collective action (SBCA). It also examines the mediating role of hope and empathy in this process. Using an experimental longitudinal field study in the context of the Israeli–Palestinian conflict, Jewish Israelis (N = 220) were randomly assigned either to an NVC or to a control condition. Results indicated that, relative to the control, participants in the NVC condition showed an increased tendency to engage in activities that are considered part of SBCA 6 weeks after the intervention. Furthermore, the NVC intervention affected both hope and empathy by maintaining higher levels of hope 6 weeks after intervention and by increasing empathy immediately after intervention. Yet hope, but not empathy, mediated the effect of the NVC intervention on participation in SBCA. Theoretical and applicable implications are discussed.
Best anticoagulation strategy with and without appendage occlusion for stroke‐prophylaxis in postablation atrial fibrillation patients with cardiac amyloidosis
Authors: Mohanty Sanghamitra , Torlapati Prem Geeta , La Fazia Vincenzo Mirco , Kurt Merve , Gianni Carola , MacDonald Bryan , Mayedo Angel , Allison John , Bassiouny Mohamed , Gallinghouse G. Joseph , Burkhardt John D. , Horton Rodney , Di Biase Luigi , Al‐Ahmad Amin , Natale Andrea 
Published: May 2024

AbstractIntroductionBoth atrial fibrillation (AF) and amyloidosis increase stroke risk. We evaluated the best anticoagulation strategy in AF patients with coexistent amyloidosis.MethodsConsecutive AF patients with concomitant amyloidosis were divided into two groups based on the postablation stroke‐prophylaxis approach; group 1: left atrial appendage occlusion (LAAO) in eligible patients and group 2: oral anticoagulation (OAC). Group 1 patients were further divided into Gr. 1A: LAAO + half‐does NOAC (HD‐NOAC) for 6 months followed by aspirin 81 mg/day and Gr. 1B: LAAO + HD‐NOAC. In group 1 patients, with complete occlusion at the 45‐day transesophageal echocardiogram, patients were switched to aspirin, 81 mg/day at 6 months. In case of leak, or dense “smoke” in the left atrium (LA) or enlarged LA, they were placed on long‐term half‐dose (HD) NOAC. Group 2 patients remained on full‐dose NOAC during the whole study period.ResultsA total of 92 patients were included in the analysis; group 1: 56 and group 2: 36. After the 45‐day TEE, 31 patients from group 1 remained on baby‐aspirin and 25 on HD NOAC. At 1‐year follow‐up, four stroke, one TIA and six device‐thrombus were reported in group 1A, compared to none in patients in group 1B (5/31 vs. 0/25, p = .03). No bleeding events were reported in group 1, whereas group 2 had five bleeding events (one subdural hematoma, one retinal hemorrhage, and four GI bleedings). Additionally, one stroke was reported in group 2 that happened during brief discontinuation of OAC.ConclusionIn patients with coexistent AF and amyloidosis, half‐dose NOAC following LAAO was observed to be the safest stroke‐prophylaxis strategy.
Norm Contestation in EU Foreign Policy: The Case of Sexual and Reproductive Health and Rights
Authors: Badell Diego 
Published: May 2024

AbstractThe EU considers gender equality fundamental to its identity, with Sexual and Reproductive Health and Rights (SRHR) playing a crucial role. This article delves into the contested aspects of EU foreign policy concerning SRHR from 1997 to 2021. Through document analysis and 18 semi‐structured interviews, it discerns three phases of contestation. Between 1997 and 2017, contestation was institutionalised within the EU, and the norm was reinforced. However, from 2017 to 2020, validity contestation arose as Hungary, Poland and the United States formed an alliance opposing SRHR, resulting in their symbolic exclusion from the EU's normative community. In 2021, within a less polarised international context (with the United States returning to consensus on SRHR), Hungary and Poland reaffirmed their commitment to the EU's SRHR consensus, highlighting the resilience of the norm.
Sporophytic control of tapetal development and pollen fertility by a mitogen‐activated protein kinase cascade in rice
Authors: Zeng Jianguo , Duan Manman , Wang Yiqing , Li Guangtao , You Yujing , Shi Jie , Liu Changhao , Zhang Jinyang , Xu Juan , Zhang Shuqun , Zhao Jing 
Published: May 2024

ABSTRACTTapetum, the innermost layer of the anther wall, provides essential nutrients and materials for pollen development. Timely degradation of anther tapetal cells is a prerequisite for normal pollen development in flowering plants. Tapetal cells facilitate male gametogenesis by providing cellular contents after highly coordinated programmed cell death (PCD). Tapetal development is regulated by a transcriptional network. However, the signaling pathway(s) involved in this process are poorly understood. In this study, we report that a mitogen‐activated protein kinase (MAPK) cascade composed of OsYDA1/OsYDA2‐OsMKK4‐OsMPK6 plays an important role in tapetal development and male gametophyte fertility. Loss of function of this MAPK cascade leads to anther indehiscence, enlarged tapetum, and aborted pollen grains. Tapetal cells in osmkk4 and osmpk6 mutants exhibit an increased presence of lipid body‐like structures within the cytoplasm, which is accompanied by a delayed occurrence of PCD. Expression of a constitutively active version of OsMPK6 (CA‐OsMPK6) can rescue the pollen defects in osmkk4 mutants, confirming that OsMPK6 functions downstream of OsMKK4 in this pathway. Genetic crosses also demonstrated that the MAPK cascade sporophyticly regulates pollen development. Our study reveals a novel function of rice MAPK cascade in plant male reproductive biology.
The Incidence of Intrahepatic Cholestasis of Pregnancy and its Maternal, Fetal, and Neonatal Adverse Outcomes: A Systematic Review and Meta‐Analysis
Authors: Odabaş Resmiye Kaya , Sökmen Yasemin , Dünder Emre , Taşpınar Ayten 
Published: May 2024

IntroductionIntrahepatic cholestasis of pregnancy (ICP) is a problem with an increasing incidence and negative maternal, fetal, and neonatal consequences. This problem is becoming increasingly important. This systematic review and meta‐analysis aimed to determine the incidence of ICP and its adverse maternal, fetal, and neonatal adverse outcomes based on primary research studies.MethodsThis systematic review and meta‐analysis used Preferred Reporting Items for Systematic Reviews and Meta‐Analyses reporting guidelines and was conducted between June and September 2023 using the following keywords: obstetric cholestasis OR intrahepatic cholestasis AND pregnancy OR pregnant OR prenatal OR antenatal OR perinatal OR maternal OR fetal OR neonatal. Quality assessment of the studies was performed using the Critical Appraisal Checklists developed by the JBI Institute. Data were synthesized using meta‐analysis methods.ResultsThe analysis included 10 studies published between 2013 and 2023. The meta‐analysis showed that the incidence of ICP was 1.7% (odds ratio [OR], 0.021; 95% CI, 0.012‐0.027), whereas maternal, fetal, and neonatal adverse outcomes included cesarean birth (OR, 2.938; 95% CI, 1.467‐5.881), preterm birth or preterm prelabor rupture of membranes (OR, 4.241; 95% CI, 1.996‐9.009), hypertensive disorders of pregnancy (OR, 3.715; 95% CI, 1.545‐8.929), maternal infection (OR, 3.301; 95% CI, 2.917‐3.737), neonatal intensive care unit admission (OR, 2.715; 95% CI, 1.458‐5.056), birth weight less than or equal to 2500 g (OR, 2.518; 95% CI, 1.296‐4.892), and small for gestational age (OR, 1.915; 95% CI, 1.424‐2.573).DiscussionThis systematic review and meta‐analysis revealed that ICP has a high incidence and several maternal, fetal, and neonatal adverse outcomes. Therefore, midwives and other health professionals must be aware of these outcomes and provide appropriate care to pregnant individuals with ICP.
The advantages of being disadvantaged
Authors: Bohas Alexandre , Grolleau Gilles , Mzoughi Naoufel 
Published: May 2024

AbstractAlthough many contributions examine how individuals and various entities (e.g., organizations and countries) manage to obtain a (competitive) advantage, there is a knowledge gap on how to make the best of disadvantages. Using notably the theories of self‐enhancement and psychological reactance, the existing literature has explained the mechanisms that can motivate and support an entity to get out from a disadvantageous position. We go further by addressing the “how” issues. We conceptualize disadvantages and adopt a provocative stance by showing how they can be transformed into valuable opportunities. Specifically, we document how being disadvantaged may be a driver of compensatory behaviors, effectual thinking, and innovation and serves as an emotional bond and in‐group marker. We also draw managerial and policy implications that offer a refreshing view on how to take advantage of disadvantages, such as changing the non‐market context and promoting the disadvantage as a market differentiation factor. As a caveat, adopting this stance should not be interpreted as a catch‐all solution that exonerates stakeholders from doing their part in providing support to disadvantaged entities.
The role of pre‐supplementary motor cortex in action control with emotional stimuli: A repetitive transcranial magnetic stimulation study
Authors: Battaglia Simone , Nazzi Claudio , Di Fazio Chiara , Borgomaneri Sara 
Published: May 2024

AbstractSwiftly halting ongoing motor actions is essential to react to unforeseen and potentially perilous circumstances. However, the neural bases subtending the complex interplay between emotions and motor control have been scarcely investigated. Here, we used an emotional stop signal task (SST) to investigate whether specific neural circuits engaged by action suppression are differently modulated by emotional signals with respect to neutral ones. Participants performed an SST before and after the administration of one session of repetitive transcranial magnetic stimulation (rTMS) over the pre‐supplementary motor cortex (pre‐SMA), the right inferior frontal gyrus (rIFG), and the left primary motor cortex (lM1). Results show that rTMS over the pre‐SMA improved the ability to inhibit prepotent action (i.e., better action control) when emotional stimuli were presented. In contrast, action control in a neutral context was fostered by rTMS over the rIFG. No changes were observed after lM1 stimulation. Intriguingly, individuals with higher impulsivity traits exhibited enhanced motor control when facing neutral stimuli following rIFG stimulation. These results further our understanding of the interplay between emotions and motor functions, shedding light on the selective modulation of neural pathways underpinning these processes.
Immunohistochemical and transcriptomic characterization of T and myeloid cell infiltrates in canine malignant melanoma
Authors: Cronise Kathryn E. , Coy Jonathan , Dow Steven , Hauck Marlene L. , Regan Daniel P. 
Published: May 2024

AbstractImmune checkpoint inhibitor therapy can provide significant clinical benefit in patients with certain cancer types including melanoma; however, objective responses are only observed for a subset of patients. Mucosal melanoma is a rare melanoma subtype associated with a poor prognosis and, compared with cutaneous melanoma, is significantly less responsive to immune checkpoint inhibitors. Spontaneous canine tumours have emerged as valuable models to inform human cancer studies. In contrast to human melanoma, most canine melanomas are mucosal—an incidence that may be leveraged to better understand the subtype in humans. However, a more comprehensive understanding of the immune landscape of the canine disease is required. Here, we quantify tumour infiltrative T and myeloid cells in canine mucosal (n = 13) and cutaneous (n = 5) melanomas using immunohistochemical analysis of CD3 and MAC387 expression, respectively. Gene expression analysis using the Canine IO NanoString panel was also performed to identify genes and pathways associated with immune cell infiltration. T and myeloid cell densities were variable with geometric means of 158.7 cells/mm2 and 166.7 cells/mm2, respectively. Elevated T cell infiltration was associated with increased expression of cytolytic genes as well as genes encoding the coinhibitory checkpoint molecules PD‐1, CTLA‐4, TIM‐3 and TIGIT; whereas increased myeloid cell infiltration was associated with elevated expression of protumourigenic cytokines. These data provide a basic characterization of the tumour microenvironment of canine malignant melanoma and suggest that, like human melanoma, inherent variability in anti‐tumour T cell responses exists and that a subset of canine melanomas may respond better to immunomodulation.
Particle verbs versus simplex verbs in Maldivian English
Authors: Bernaisch Tobias , Suad Aishath , Saeed Aminath 
Published: May 2024

AbstractNotwithstanding current indications that English might soon become the country's dominant L1, the structures of English in the Maldives have—despite laudable exceptions—not yet received sufficient academic attention. The present paper studies the contrast between simplex verbs (e.g. COMPRISE) and their innovative particle–verb alternatives (e.g. COMPRISE of) (a) in a short‐term diachronic database of Maldivian newspaper texts and (b) with the help of acceptability ratings of the forms concerned collected through an online survey. The research questions address the relative frequencies of use of innovative particle verbs as opposed to corresponding simplex verbs, the diachronic variability of these relative frequencies and the degree to which the local speech community accepts innovative verb–particle combinations. While the well‐established simplex verbs constitute the overall dominant structural choices, each of the innovative particle verbs has become more frequent in the course of the 14‐year time period observed. These corpus‐based insights align with the generally high acceptability ratings for the innovative particle–verb constructions evident from the survey data, where young women display the largest degree of acceptance towards the innovative particle verbs.