bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Exposure to Potential CYP450 Pharmacokinetic Drug–Drug Interactions among Patients with Chronic Low Back Pain Taking Opioids
Authors: Pergolizzi, Jr. Joseph V. , Labhsetwar Sumedha A. , Puenpatom R. Amy , Joo Seongjung , Ben‐Joseph Rami H. , Summers Kent H. 
Published: August 2010

AbstractDrug–drug interactions (DDIs) have been defined as two or more drugs interacting in such a way that the effectiveness and/or toxicity of one or all drugs are changed. Patients taking more than one drug metabolized through the cytochrome P450 (CYP450) enzyme system, including some, but not all, opioids experience a drug–drug exposure (DDE), which may result in a potentially dangerous DDI. Using a retrospective analysis of a large commercial claims database and a Medicare database, we evaluated DDEs that have the potential to cause DDIs among chronic low back pain (cLBP) patients on long‐term opioid analgesia, which metabolizes through the CYP450 enzyme system, concomitant with other CYP450‐metabolized drug(s). The overall prevalence of DDEs among cLBP patients was 27%. Women had a higher prevalence of DDEs (30.6% vs. 22% for men). Patients aged 45 to 55 and 56 to 64 years had the highest prevalence of DDEs (30.4% and 29.8%, respectively), followed by patients 34 to 45 years (27.9%). For patients > 65 years, the prevalence of DDEs was 23.1%. In general, the prevalence of DDEs was fairly consistent across age ranges in this population. This study suggests that DDEs are common in the cLBP population. When selecting an opioid to treat cLBP, physicians should consider the potential for exposure of these patients to drugs that might unfavorably interact and, for that reason, the use of opioids that do not rely on the CYP450 system as their primary means of metabolism might be worthy of consideration.
Comparison of platelet transfusion as fresh whole blood versus apheresis platelets for massively transfused combat trauma patients (CME)
Authors: Perkins Jeremy G. , Cap Andrew P. , Spinella Philip C. , Shorr Andrew F. , Beekley Alec C. , Grathwohl Kurt W. , Rentas Francisco J. , Wade Charles E. , Holcomb John B. ,   the 31st Combat Support Hospital Research Group
Published: August 2010

BACKGROUND: At major combat hospitals, the military is able to provide blood products to include apheresis platelets (aPLT), but also has extensive experience using fresh whole blood (FWB). In massively transfused trauma patients, we compared outcomes of patients receiving FWB to those receiving aPLT.STUDY DESIGN AND METHODS: This study was a retrospective review of casualties at the military hospital in Baghdad, Iraq, between January 2004 and December 2006. Patients requiring massive transfusion (≥10 units in 24 hr) were divided into two groups: those receiving FWB (n = 85) or aPLT (n = 284) during their resuscitation. Admission characteristics, resuscitation, and survival were compared between groups. Multivariate regression analyses were performed comparing survival of patients at 24 hours and at 30 days. Secondary outcomes including adverse events and causes of death were analyzed.RESULTS: Unadjusted survival between groups receiving aPLT and FWB was similar at 24 hours (84% vs. 81%, respectively; p = 0.52) and at 30 days (60% versus 57%, respectively; p = 0.72). Multivariate regression failed to identify differences in survival between patients receiving PLT transfusions either as FWB or as aPLT at 24 hours or at 30 days.CONCLUSIONS: Survival for massively transfused trauma patients receiving FWB appears to be similar to patients resuscitated with aPLT. Prospective trials will be necessary before consideration of FWB in the routine management of civilian trauma. However, in austere environments where standard blood products are unavailable, FWB is a feasible alternative.
Pooled peripheral blood mononuclear cells provide an optimized cellular substrate for human immunodeficiency virus Type 1 isolation during acute infection
Authors: Lai‐Hipp Christopher , Goldberg Tiffany , Scott Edward , Ziman Alyssa , Vyas Girish 
Published: August 2010

BACKGROUND: Cellular substrate (CS) composed of phytohemagglutinin (PHA)‐stimulated PBMNCs is required for isolating primary human immunodeficiency virus Type 1 from plasma (PHIV) during early acute infection. The transmitted founder PHIV is neutralization‐sensitive and uses chemokine‐receptor 5 to infect CD4‐positive PBMNCs. Therefore, PHIV cocultured with optimized CS would enable efficient virologic diagnosis, vaccine development, and tests for broadly neutralizing antibodies (bnAb).STUDY DESIGN AND METHODS: Fifteen leukapheresis donations were used to isolate CD4‐enriched PBMNCs. Individual or three or four donors' pooled cells were stimulated with PHA, and both CSs were evaluated in parallel cocultures using five different PHIV isolates from nucleic acid testing–positive anti‐HIV–negative donations. Feasibility of coculturing PHIV with pooled PBMNC‐CS after dimethyl sulfoxide cryopreservation was investigated.RESULTS: The cell‐free supernatants from individual CSs contained mean HIV‐p24 antigen varying between 20.35 and 85.54 ng/mL, while that from pooled CSs ranged between 57.54 and 88.10 ng/mL. Thus, PBMNCs pooled from multiple donors provide an optimal CS for coculturing PHIV. Cryopreserved PBMNC‐CS for PHIV cocultures is promising for systematic biosynthesis of PHIV.CONCLUSIONS: Pooled CSs after cryopreservation were functional for PHIV replication and enable on‐demand diagnostic cocultures, preparing panels of PHIV stocks for bnAb testing and developing an envelope‐subunit vaccine candidate analogous to hepatitis B surface antigen, proven successful in preventing hepatitis B virus infection.
Retroperitoneal Hematoma in Patients Undergoing Cardiac Catheterization
Authors: FRANK JOHN J. , KAMALAKANNAN DESIKAN , KODENCHERY MIHAS , SAVOY‐MOORE RUTH T. , ROSMAN HOWARD 
Published: August 2010

Objective:
To retrospectively study demographic, clinical and hospital outcomes in patients who developed RPH following cardiac catheterization.
Methods:
Charts of patients with RPH from cardiac catheterization, between January 1, 2000 and July 30, 2005 were reviewed and compared with two control groups (Grp‐I, 90 patients with local groin complications and Grp‐II, 98 patients with no bleeding complications).
Results:
31 cases of RPH (0.13%) were identified with 84% females. Most common presentation was hypotension (87%) and hemoglobin drop (96%). CT scan was the diagnostic modality in 93% cases. The mean body surface area in RPH group (1.77 ± .23) was significantly lower than in control group I (1.93 ± .28) and II (1.98 ± .27). The use of larger sheath size was significantly higher in the RPH group (61.3%) than control groups I (26.7%) and II (21.4%). Left groin access was significantly more in RPH group (16.1%) and control group I (17.8) than control group II (0%). The use of antiplatelets and anticoagulants were significantly higher in the RPH group. 13% of patients with RPH were treated surgically. The average hospital stay was 8.6 days, 4.5 days and 3.5 days and mortality 12.9%, 3.3% and 1% in RPH group, control group I and II respectively.
Conclusion:
Our study is the second largest series of RPH following cardiac catheterization and predicts female gender, large sheath size, left groin access and low body surface area as risk factors for RPH. (J Interven Cardiol 2010;23:569–574)
Endovascular Abdominal Aortic Aneurysm Repair by Interventional Cardiologists—A Community‐Based Experience
Authors: BASOOR ABHIJEET , PATEL KIRITKUMAR C. , COTANT JOHN F. , HALABI ABDUL R. , TODOROV MINA , CHUGHTAI HAROON , CHOKSI NISHIT , DIACZOK BENJAMIN , ZONIA SUSAN , DEGREGORIO MICHELE 
Published: August 2010

Introduction:
Endovascular repair of abdominal aortic aneurysm (AAA) is a relatively recent technology. In comparison to the conventional open surgical treatment for AAA, endovascular AAA repair (EVAR) combines a less‐invasive approach with lower morbidity and mortality. There have been few studies regarding the performance of this procedure in a community‐based setting. We report our experience of EVAR performed primarily by interventional cardiologists in a community hospital.
Methods:
In our community hospital setting, between September 2005 and November 2007, we included all patients who underwent EVAR by interventional cardiologists, with available on‐site vascular surgical support. Clinical and serial computed angiographic imaging outcomes were followed by a retrospective chart review. Data collection tools included demographic and clinical characteristics, anatomical aneurysm features, length of stay, peri‐ and postprocedural complications, and mortality.
Results:
A total of 71 consecutive patients had EVAR attempted. The endovascular stent placement was successful in 67 (93%) patients. Thirty‐day mortality in this study was 1 of 71 (1.4%). All four procedural failures and the single periprocedural mortality occurred in women. Mean follow‐up was 12 months. There were a total of six mortalities and among these four were women (P ≤ 0.001); however, multivariate analysis revealed loss of significant difference in mortality (P = 0.16). Major complications following EVAR were noted in 10 of 71 (14%) patients.
Conclusion:
EVAR can be successfully performed by experienced interventional cardiologists with vascular surgical support in a community‐based setting. In our experience, there is acceptable rate of complications and mortality in a carefully selected patient population. (J Interven Cardiol 2010;23:485–490)
Interventions to improve hemodialysis adherence: A systematic review of randomized‐controlled trials
Authors: MATTESON Michelle L. , RUSSELL Cynthia 
Published: August 2010

AbstractOver 485,000 people in the United States have chronic kidney disease, a progressive kidney disease that may lead to hemodialysis. Hemodialysis involves a complex regimen of treatment, medication, fluid, and diet management. In 2005, over 312,000 patients were undergoing hemodialysis in the United States. Dialysis nonadherence rates range from 8.5% to 86%. Dialysis therapy treatment nonadherence, including treatment, medication, fluid, and diet nonadherence, significantly increases the risk of morbidity and mortality. The purpose of this paper is to systematically review randomized‐controlled trial intervention studies designed to increase treatment, medication, fluid, and diet adherence in adult hemodialysis patients. A search of Cumulative Index of Nursing and Allied Health Literature (CINAHL) (1982 to May 2008), MEDLINE (1950 to May 2008), PsycINFO (1806 to May 2008), and all Evidence‐Based Medicine (EBM) Reviews (Cochran DSR, ACP Journal Club, DARE, and CCTR) was conducted to identify randomized‐controlled studies that tested the efficacy of interventions to improve adherence in adult hemodialysis patients. Eight randomized‐controlled trials met criteria for inclusion. Six of the 8 studies found statistically significant improvement in adherence with the intervention. Of these 6 intervention studies, all studies had a cognitive component, with 3 studies utilizing cognitive/behavioral intervention strategies. Based on this systematic review, interventions utilizing a cognitive or cognitive/behavioral component appear to show the most promise for future study.
Comparison of risk factors for contrast‐induced acute kidney injury between patients with and without diabetes
Authors: PAKFETRAT Maryam , NIKOO Mohamad Hosein , MALEKMAKAN Leila , TABANDE Mahmood , ROOZBEH Jamshid , GANBAR ALI Raiss Jalali , KHAJEHDEHI Parviz 
Published: August 2010

AbstractAlthough it is well known that diabetics are at a higher risk of contrast‐induced acute kidney injury (CI‐AKI) than nondiabetic patients, the reason for this discrepancy is not well known. Thus, in this study, we compared the predisposing factors for CI‐AKI between patients with and without diabetes. We prospectively studied 290 consecutive in‐hospital patients including 88 diabetics undergoing coronary angiography or a percutaneous coronary intervention in Kowsar hospital, and we compared risk factors for CI‐AKI between diabetic and nondiabetic patients. CI‐AKI was defined as RIFLE criteria within 48 hours after contrast exposure. The incidence of CR‐AKI was significantly higher in diabetic patients compared with nondiabetics (P<0.05). The incidence of CI‐AKI was significantly higher in patients with diabetes and left‐ventricular ejection fraction ≤40%, hypercholesterolemia, serum creatinine ≥1.1 mg/dL, estimated glomerular filtration rate (eGFR) <90 mL/min, Contrast volume ≥80 (mL), maximum safe contrast volume factor of 1.5, and dehydration, while in nondiabetics, a significantly higher incidence of CR‐AKI was observed in those with serum creatinine ≥1.1 mg/dL (P=0.02) and/or eGFR<60 mL/min (P=0.01). Multiple logistic regression analysis showed hyperchlosteremia to be the strongest predictor of AKI (P=0.01, B:14.5) in diabetics, followed by eGFR<90 (P=0.05, B:12.4) but, in nondiabetics, only eGFR<60 predicted the occurrence of CI‐AKI (P=0.04, B:2.3). It seems that the predisposing factors to CI‐AKI differ in diabetics and nondiabetics. In patients with diabetes, hypercholesterolemia is the strongest predictor of CI‐AKI, followed by eGFR and diabetics are at risk for CI‐AKI in the early stage of chronic kidney disease (stage 2), accounting for the higher incidence of CI‐AKI in them.
Flapless immediate implant placement with or without immediate loading: a histomorphometric study in beagle dog
Authors: Blanco Juan , Liñares Antonio , Villaverde Gabriel , Pérez Javier , Muñoz Fernando 
Published: August 2010

Blanco J, Liñares A, Villaverde G, Pérez J, Muñoz F: Flapless immediate implant placement with or without immediate loading. a histomorphometric study in beagle dog. J Clin Periodontol 2010; 37: 937–942. doi: 10.1111/j.1600‐051X.2010.01608.x.AbstractObjective: To assess the osseointegration process after flapless immediate implant placement with or without immediate loading.Material and Methods: This study was carried out on six beagle dogs. Four implants were placed in the lower jaw (two per side) in each dog immediately after tooth extraction (3rd and 4th premolars). Flapless immediate implant placement was performed in one hemimandible (control). The same procedure was carried out in the contra‐lateral side and immediate prosthesis was connected with occlusal contacts (test). After 3 months of healing, the dogs were sacrificed for histomorphometric analysis.Results: Twelve implants were placed in each group. None of the implants and prosthesis was lost. The percentage of bone‐to‐implant contact (BIC %) was similar in both groups: 82.72% (test) and 76.96% (control). Differences were found neither in the inter‐thread bone area (test: 83.45%, control: 80.65%) nor in peri‐implant bone area (test: 94.37%, control: 94.81%).Conclusion: In this animal model where the implants were well within the confines of the extraction socket, osseointegration following flapless immediate implant placement and loading can be achieved in the same manner as immediate placement without loading.
A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery
Authors: Duss Christof , Lang Niklaus P. , Cosyn Jan , Persson G. Rutger 
Published: August 2010

Duss C, Lang NP, Cosyn J, Persson GR. A randomized, controlled clinical trial on the clinical, microbiological, and staining effects of a novel 0.05% chlorhexidine/herbal extract and a 0.1% chlorhexidine mouthrinse adjunct to periodontal surgery. J Clin Periodontol 2010; 37: 988–997. doi: 10.1111/j.1600‐051X.2010.01609.x.AbstractBackground: Chlorhexidine (CHX) rinsing after periodontal surgery is common. We assessed the clinical and microbiological effects of two CHX concentrations following periodontal surgery.Materials and methods: In a randomized, controlled clinical trial, 45 subjects were assigned to 4 weeks rinsing with a 0.05 CHX/herbal extract combination (test) or a 0.1% CHX solution. Clinical and staining effects were studied. Subgingival bacteria were assessed using the DNA–DNA checkerboard. Statistics included parametric and non‐parametric tests (p<0001 to declare significance at 80% power).Results: At weeks 4 and 12, more staining was found in the control group (p<0.05 and p<0.001, respectively). A higher risk for staining was found in the control group (crude OR: 2.3:1, 95% CI: 1.3 to 4.4, p<0.01). The absolute staining reduction in the test group was 21.1% (9 5% CI: 9.4–32.8%). Probing pocket depth (PPD) decreases were significant (p<0.001) in both groups and similar (p=0.92). No rinse group differences in changes of bacterial counts for any species were found between baseline and week 12.Conclusions: The test CHX rinse resulted in less tooth staining. At the study endpoint, similar and high counts of periodontal pathogens were found.
Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis
Authors: Franek Edward , Napora Magdalena , Blach Anna , Budlewski Tadeusz , Gozdowski Dariusz , Jedynasty Krystyna , Krajewski Jarosław , Gorska Renata 
Published: August 2010

Franek E, Napora M, Blach A, Budlewski T, Gozdowski D, Jedynasty K, Krajewski J, Gorska R. Blood pressure and left ventricular mass in subjects with type 2 diabetes and gingivitis or chronic periodontitis. J Clin Periodontol 2010; 37: 875–880. doi: 10.1111/j.1600‐051X.2010.01613.x.AbstractIntroduction: This study aimed to answer the question of whether chronic periodontitis in subjects with type 2 diabetes mellitus is associated with increased left ventricular mass (LVM) and systemic and central blood pressure (CBP).Material and Methods: One hundred and fifty‐five subjects with type 2 diabetes (67 F, 88 M, mean age 61.1±6.9 years, BMI 32.7±5.7 kg/m2) were divided according to their periodontal status into biofilm–gingival interface – healthy (BGI‐H, 14 subjects), BGI‐gingivitis (BGI‐G, 119 subjects) and BGI‐periodontitis (BGI‐P, 22 subjects) groups. In all subjects, LVM, systemic and CBP were measured. The LVM index (LVMI) was calculated.Results: (1) BGI‐P and BGI‐G subjects, respectively, had higher (mean; 95% CI) LVM (238.6 g; 206.6–267.4 and 222.8 g; 207.0–238.2) versus BGI‐H subjects (170.3 g; 125.5–217.8). (2) BGI‐P and BGI‐G subjects, respectively, had higher (mean; 95% CI) LVM1 (95.2 g/m2; 82.9–107.4) and 87.8 g/m2; 81.5–94.1) versus BGI‐H subjects (63.7 g/m2; 45.2‐62.3). (3) BGI‐P subjects had higher central and systemic systolic and diastolic blood pressure than subjects from BGI‐G and BGI‐H groups.Conclusion: In subjects with type 2 diabetes, periodontitis and gingivitis are associated with increased LVM and periodontitis is associated with increased central and systemic blood pressure.
Platelet‐rich plasma may prevent titanium‐mesh exposure in alveolar ridge augmentation with anorganic bovine bone
Authors: Torres Jesús , Tamimi Faleh , Alkhraisat Mohammad Hamdan , Manchón Ángel , Linares Rafael , Prados‐Frutos Juan Carlos , Hernández Gonzalo , López Cabarcos Enrique 
Published: August 2010

Torres J, Tamimi F, Alkhraisat MH, Manchón Á, Linares R, Prados‐Frutos JC, Hernández G, López Cabarcos E. Platelet‐rich plasma may prevent titanium‐mesh exposure in alveolar ridge augmentation with anorganic bovine bone. J Clin Periodontol 2010; 37: 943–951. doi: 10.1111/j.1600‐051X.2010.01615.x.AbstractObjective: Bone augmentation with the titanium‐mesh (Ti‐mesh) technique is susceptible to a large rate of complications such as morbidity of bone graft donor site, and mesh exposure to the oral cavity. The purpose of this study was to evaluate the effectiveness of anorganic bovine bone (ABB) in alveolar bone augmentation with the Ti‐mesh technique. In addition, we investigated the effect of platelet‐rich plasma (PRP) in preventing mesh exposure by using it to cover the Ti‐mesh.Patients and Methods: Patients included in the clinical trial were randomly allocated by a blinded assistant into two groups. The 30 patients recruited for this study underwent 43 alveolar bone augmentation with the Ti‐mesh technique using ABB as graft material in all of them. In 15 patients, the Ti‐meshes were covered with PRP (PRP group) whereas in the other 15 the Ti‐meshes were not (control group). After 6 months, patients were called for clinical, radiographic, and histological evaluation, and implant placement surgery. A total of 97 implants were placed in the augmented bone and their evolution was followed up for a period of 24 months.Results: Significant differences were found between the two study groups in terms of complications and bone formation. In the control group, 28.5% of the cases suffered from mesh exposure, while in the PRP group, no exposures were registered. Radiographic analysis revealed that bone augmentation was higher in the PRP group than in the control group. Overall, 97.3% of implants placed in the control group and 100% of those placed in the PRP group were successful during the monitoring period. We suggest that the positive effect of PRP on the Ti‐mesh technique is due to its capacity to improve soft tissue healing, thereby protecting the mesh and graft material secured beneath the gingival tissues.Conclusions: Alveolar bone augmentation using ABB alone in the Ti‐mesh technique is sufficient for implant rehabilitation. Besides, covering the Ti‐meshes with PRP was a determining factor in avoiding mesh exposure. Ti‐mesh exposure provoked significant bone loss, but in most cases it did not affect the subsequent placement of implants.
Bisphosphonates affect migration ability and cell viability of HUVEC, fibroblasts and osteoblasts in vitro
Authors: Walter C , Pabst A , Ziebart T , Klein MO , Al‐Nawas B 
Published: August 2010

Oral Diseases (2011) 17, 194–199Objectives:  Bisphosphonate‐associated osteonecrosis of the jaw (BP‐ONJ) is a side effect in patients being treated with bisphosphonates. The bisphosphonates most often associated with BP‐ONJ are the highly potent nitrogen‐containing bisphosphonates, e.g. pamidronate or zoledronate. In terms of BP‐ONJ aetiology, several theories are being discussed: inhibition of bone remodelling, effect on soft tissues, and antiangiogenic effect of bisphosphonates. The aim of this in vitro study was to investigate the effect of different potent bisphosphonates on osteoblasts, fibroblasts and human umbilicord vein endothelial cells (HUVEC).Materials and methods:  Three nitrogen‐containing bisphosphonates (ibandronate, pamidronate and zoledronate) and one non‐nitrogen‐containing bisphosphonate (clodronate) were compared concerning their potency on apoptosis induction (tunel), cell viability (calcein assay) and migration potency (boyden chamber) on osteoblasts, fibroblasts and HUVEC.Results:  The nitrogen‐containing bisphosphonates, particularly pamidronate and zoledronate, affect cell viability, cell migration and the induction of apoptosis of osteoblasts, fibroblasts and HUVEC.Conclusions:  These results support the theory that BP‐ONJ is a multifactorially caused disease because several cell lines of the oral cavity which are responsible for integrity and wound healing are negatively affected by nitrogen‐containing bisphosphonates. Perioperative interruption of bisphosphonate application during dental surgical procedures – if possible – might be feasible to promote better wound healing.