bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Nanostructured Self‐Assembly Materials Formed by Non‐Ionic Urea Amphiphiles
Authors: Gong Xiaojuan , Sagnella Sharon , Drummond Calum J. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Process Selection of Biosolids: Management Systems
Authors: Shammas Nazih K. , Wang Lawrence K. 
Published: September 2009

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Use of (S)‐BINOL as NMR chiral solvating agent for the enantiodiscrimination of omeprazole and its analogs
Authors: Redondo Jordi , Capdevila Anna , Latorre Isabel 
Published: September 2009

AbstractThe application of (S)‐1,1′‐binaphthyl‐2,2′‐diol as NMR chiral solvating agent (CSA) for omeprazole, and three of its analogs (lanso‐, panto‐, and rabe‐prazole) was investigated. The formation of diastereomeric host–guest complexes in solution between the CSA and the racemic substrates produced sufficient NMR signal splitting for the determination of enantiomeric excesses by 1H‐ or 19F‐NMR spectroscopy. Using of hydrophobic deuterated solvents was mandatory for obtaining good enantiodiscrimination, thus suggesting the importance of intermolecular hydrogen bonds in the stabilization of the complexes. The method was applied to the fast quantification of the enantiomeric purity of in‐process samples of S‐omeprazole. Chirality, 2010. © 2009 Wiley‐Liss, Inc.
Circular dichroism spectra, optical rotations and absolute configurations of cis‐dihydrodiol metabolites of quinoline and derivatives: The role of the nitrogen atom
Authors: Kwit Marcin , Gawronski Jacek , Sbircea Lenuta , Sharma Narain D. , Kaik Magdalena , Boyd Derek R. 
Published: September 2009

AbstractThe absolute configurations of cis‐dihydrodiol bacterial metabolites derived from quinoline substrates and their quinolinium salts have been determined by comparison of experimental and calculated chiroptical data (circular dichroism spectra and optical rotations). The role of intramolecular H‐bonding and other interactions in the preferred conformations has been investigated, including the effect of protonation of several cis‐dihydrodiols. The presence of a strong intramolecular OH···N bond in several cis‐dihydrodiol metabolites suggests that such species have a residually chiral oxygen atom. Chirality 21:E37–E47, 2009. © 2009 Wiley‐Liss, Inc.
Theoretical approaches to the calculation of Raman optical activity spectra
Authors: Ruud Kenneth , Thorvaldsen Andreas J. 
Published: September 2009

AbstractIn this article, we will give a brief account of the different approaches that have been presented in the literature for calculating Raman optical activity (ROA) spectra by ab initio methods. We will also outline the general structure of a self‐consistent‐field‐based approach for analytic calculations of ROA spectra, including also contributions from London orbitals. The use of London orbitals ensures that the relevant ROA parameters are gauge origin independent. We will also give an outlook on the future of ab initio calculations of Raman optical activity spectra. Chirality 21:E54–E67, 2009. © 2009 Wiley‐Liss, Inc.
From Structure–Activity to Structure–Selectivity Relationships: Quantitative Assessment, Selectivity Cliffs, and Key Compounds
Authors: Peltason Lisa , Hu Ye , Bajorath Jürgen 
Published: September 2009

AbstractThe exploration of structure–activity relationships (SARs) in chemical lead optimization is mostly focused on activity against single targets. Because many active compounds have the potential to act against multiple targets, achieving a sufficient degree of target selectivity often becomes a major issue during optimization. Herein we report a data analysis approach to explore compound selectivity in a systematic and quantitative manner. Sets of compounds that are active against multiple targets provide a basis for exploring structure–selectivity relationships (SSRs). Compound similarity and selectivity data are analyzed with the aid of network‐like similarity graphs (NSGs), which organize molecular networks on the basis of similarity relationships and SAR index (SARI) values. For this purpose, the SARI framework has been adapted to quantify SSRs. Using sets of compounds with differential activity against four cathepsin thiol proteases, we show that SSRs can be quantitatively described and categorized. Furthermore, local SSR environments are identified, the analysis of which provides insight into compound selectivity determinants at the molecular level. These environments often contain “selectivity cliffs” formed by pairs or groups of similar compounds with significantly different selectivity. Moreover, key compounds are identified that determine characteristic features of single‐target SARs and dual‐target SSRs. The comparison of compounds involved in the formation of selectivity cliffs often reveals chemical modifications that render compounds target selective.
Virtual‐core flow cytometry
Authors: Swalwell Jarred E. , Petersen Timothy W. , van den Engh Ger 
Published: September 2009

AbstractTraditional flow cytometers use a sheath fluid to position particles or cells for cytometric measurements, but the need for sheath fluid greatly complicates flow cytometric instrumentation. A cytometric detector that is free of the requirements of sheath fluid can simplify the design of flow cytometers and can extend their use into a number of areas. We designed a flow cytometer that uses a combination of three photodetectors to sense the position of a particle in sample stream. The position‐sensitive detectors create a virtual core in the sample stream that eliminates the need for sheath fluid. In this article, we demonstrate the efficacy of a virtual‐core flow cytometer (VCFC) using test particles, immunofluorescently labeled thymocytes, and raw seawater. The VCFC performs accurate measurements that can be used for a number of uses including environmental monitoring or simple immunology tests. © 2009 International Society for Advancement of Cytometry
Alloantigen‐specific de novo‐induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD
Authors: Koenecke Christian , Czeloth Niklas , Bubke Anja , Schmitz Susanne , Kissenpfennig Adrien , Malissen Bernard , Huehn Jochen , Ganser Arnold , Förster Reinhold , Prinz Immo 
Published: September 2009

AbstractInduced antigen‐specific Foxp3+ T cells (iTreg) are being discussed as a promising alternative to polyclonal natural Foxp3+ T cells (nTreg) for cell‐based therapies, particularly to achieve transplantation tolerance. Using Foxp3eGFP‐reporter mice, we here establish an efficient protocol to induce and expand alloantigen‐specific iTreg from Foxp3−CD4+ T cells with cluster‐disrupted DC. These iTreg were mainly CD62L+ and showed efficient suppressive activity in vitro. However, in contrast to nTreg, adoptively transferred iTreg entirely failed to prevent lethal graft versus host disease (GVHD). Within irradiated recipients, the majority of adoptively transferred Foxp3+ iTreg, but not Foxp3+ nTreg quickly reverted to Foxp3−CD4+ T cells. We therefore suggest that therapeutic approaches to treat GVHD should rely on nTreg, whereas the use of de novo alloantigen‐induced iTreg should be handled with caution since the stability of the regulatory phenotype of the iTreg could be of major concern.
Evidence that cathelicidin peptide LL‐37 may act as a functional ligand for CXCR2 on human neutrophils
Authors: Zhang Zhifang , Cherryholmes Gregory , Chang Frances , Rose David M. , Schraufstatter Ingrid , Shively John E. 
Published: September 2009

AbstractLL‐37, derived from human cathelicidin, stimulates immune responses in neutrophils. Although FPR2 and P2X7 were proposed as LL‐37 receptors, we have shown that among 21 neutrophil receptors only CXCR2 was down‐regulated by LL‐37. LL‐37 functions similarly to CXCR2‐specific chemokines CXCL1 and CXCL7 in terms of receptor down‐regulation and intracellular calcium mobilization on freshly isolated neutrophils. Neutrophils pretreated with CXCL8, a chemokine that binds both CXCR1/2, completely blocked the calcium mobilization in response to LL‐37, while LL‐37 also partially inhibited 125I‐CXCL8 binding to neutrophils. SB225002, a selective CXCR2 antagonist, blocked LL‐37‐induced calcium mobilization and migration of neutrophils. LL‐37 stimulates calcium mobilization in CXCR2‐transfected HEK293 cells, CXCR2+ THP‐1 cells and monocytes, but not in CXCR1‐transfected HEK293 cells. WKYMVm peptide (ligand for FPR2) does not block LL‐37‐stimulated calcium flux in either THP‐1 (FPR2−) or monocytes (FPR2high), further confirming the specificity of LL‐37 for CXCR2 and not FPR2. Among all ligands tested (ATP, BzATP, WKYMVm, CXCL1, and LL‐37), only LL‐37 stimulated migration of monocytes (CXCR2+ and FPR2+) and migration was inhibited by the CXCR2 inhibitor SB225002. Moreover, CXCR2 but not CXCR1 was internalized in LL‐37‐treated neutrophils. Thus, our data provide evidence that LL‐37 may act as a functional ligand for CXCR2 on human neutrophils.
Insertion of CO and Strained Olefins into Organometallic (Ferrocenylmethyl)phosphane Palladium Complexes
Authors: Dell'Anna Maria Michela , Giardina‐Papa Daniela , Ibáñez Susana , Martín Antonio , Mastrorilli Piero , Nobile Cosimo Francesco , Peruzzini Maurizio 
Published: September 2009

AbstractThe reaction of [Pd(cod)(CH3)Cl] (cod = 1,5‐cyclooctadiene) with the primary phosphane (ferrocenylmethyl)phosphane (PH2CH2Fc, 1, 2 equiv.) affords trans‐[Pd(PH2CH2Fc)2(CH3)Cl] (2) in 95 % yield. The intermediate chlorido‐bridged dinuclear complex [Pd(PH2CH2Fc)(CH3)(μ‐Cl)]2 (3) is traversed along the formation of 2. Complex 3 may be isolated as a mixture of anti‐3a and syn‐3b isomers by treating [Pd(cod)(CH3)Cl] with 1 (1 equiv.). For comparison, the analogous reactions of 1 with [Pt(cod)(CH3)Cl] gives [Pt(PH2CH2Fc)2(CH3)Cl] as a mixture of cis‐4a and trans‐4b geometric isomers, regardless of the P/Pt molar ratio used. The insertion (at 1 atm and 253 K) of CO into the methyl–Pd bonds of either 2 or 3 gives the acetyl Pd complexes trans‐[Pd(PH2CH2Fc)2(COCH3)Cl] (5) and anti‐[Pd(PH2CH2Fc)(COCH3)(μ‐Cl)]2 (6), respectively. The process leading from 3 to 6 occurs without fragmentation of the dinuclear core of the complexes, lending support to an associative mechanism with CO binding to the metal. Complex 6 undergoes facile insertion of strained olefins, such as norbornadiene or norbornene, into the acetyl–palladium bond, giving the complexes [Pd(κ2C,O‐C7H8C(O)CH3)(Cl)(PH2CH2Fc)] (7) and [Pd(κ2C,O‐C7H10C(O)CH3)(Cl)(PH2CH2Fc)] (8), respectively. Complexes 3 were tested as precatalysts for the vinylic polymerization of norbornene at 253 K, as well as for the alternate copolymerization of carbon monoxide with norbornene.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Characteristic Structures and Photophysical Properties of Nine‐Coordinate Europium(III) Complexes with Tandem‐Connected Tridentate Phosphane Oxide Ligands
Authors: Miyata Kohei , Hasegawa Yasuchika , Kuramochi Yusuke , Nakagawa Tetsuya , Yokoo Toshiaki , Kawai Tsuyoshi 
Published: September 2009

AbstractStructures and photophysical properties of f‐block metal complexes with tandem‐connected tridentate phosphane oxide ligands, {bis[o‐(diphenylphosphoryl)phenyl]phenylphosphane oxide}tris(hexafluoroacetylacetonato)europium(III) [Eu(hfa)3(DPPPO)], {bis[o‐(diphenylphosphoryl)pyridyl]phenylphosphane oxide}tris(hexafluoroacetylacetonato)europium(III) [Eu(hfa)3(DPPYPO)] and {bis[o‐(diphenylphosphoryl)benzothienyl]phenylphosphane oxide}tris(hexafluoroacetylacetonato)europium(III) [Eu(hfa)3(DPBTPO)], are reported. The coordination geometries of Eu(hfa)3(DPPPO) and Eu(hfa)3(DPBTPO) provide characteristic distorted, capped square antiprism structures with nine‐coordinate oxygen atoms. The emission properties related to the electric transition are characterized by the emission spectra, the emission quantum yields, the emission lifetimes, and the radiative and non‐radiative rate constants. EuIII complexes with tridentate phosphane oxide ligands offer relatively high emission quantum yields (> 60 % in [D6]acetone) due to their low‐symmetric and low‐frequency vibrational structures. The electric dipole transition intensities in the emission spectra depend on the chemical structures of tridentate phosphane oxides. The characteristic photophysical properties of polyhedral f‐block metal complexes, nine‐coordinate EuIII complexes with tridentate phosphane oxide, are demonstrated for the first time.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Synthesis and structural consideration of 1‐chloro‐N,N′,N″‐tris(pentafluorophenyl)azagermatrane: Azagermatrane with the shortest intramolecular N → Ge bond
Authors: Lermontova El'mira Kh. , Churakov Andrei V. , Howard Judith A. K. , Oprunenko Yuri F. , Karlov Sergey S. , Zaitseva Galina S. 
Published: September 2009

AbstractTwo compounds of a novel‐type azagermatrane, N(CH2CH2NC6F5)3Ge‐Hal: HalCl (1), Br (2), were prepared via a metathetical reaction of trilithium salt of tetramine, N[CH2CH2N(Li)C6F5]3, with corresponding GeHal4. A single crystal structure of 1 was determined by the X‐ray diffraction study: The compound shows the strongest transannular Nax → Ge interaction (2.148(7) Å) among other studied azagermatranes. © 2008 Wiley Periodicals, Inc. Heteroatom Chem 19:738–741, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20476
5‐phosphorylated 1,2‐disubstituted imidazoles
Authors: Yurchenko A. A. , Huryeva A. N. , Zarudnitskii E. V. , Marchenko A. P. , Koidan G. N. , Pinchuk A. M. 
Published: September 2009

Abstract1,2‐Disubstituted imidazoles react with phosphorus(III) halides in pyridine regioselectively at position 5. The reaction proceeds the more readily, the higher the electron‐donating ability of the 2‐substituent in the starting imidazole. Hitherto unknown dihalo(imidazol‐5‐yl)phosphines have been obtained, and their properties have been studied. Also synthetic methods for the preparation of various monohalo(organyl)(imidazolyl)phosphines have been developed. © 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:289–308, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20550
Corneal epithelial cell adhesion and growth on EGF‐modified aminated PDMS
Authors: Klenkler Bettina J. , Dwivedi Dhruva , West‐Mays Judith A. , Sheardown Heather 
Published: September 2009

AbstractGrowth factor tethering has significant potential to mediate cellular responses in biomaterials and tissue engineering. We have previously demonstrated that epidermal growth factor (EGF) can be tethered to polydimethylsiloxane (PDMS) substrates and that these surfaces promoted interactions with human corneal epithelial cellsin vitro. The goal of the current work was to better understand the specific effects of the tethered growth factor on the cells. The EGF was reacted with a homobifunctionalN‐hydroxysuccinimide (NHS) polyethylene glycol (PEG) derivative, and then bound to allyamine plasma‐modified PDMS. Human corneal epithelial cells were seeded on the surfaces and cultured in serum‐free medium for periods of up to 5 days. Cell growth was monitored and quantified by trypsinization and counting with a Coulter counter. Expression of matrix proteins and α6‐integrins was assessed by immunostaining and confocal microscopy. A centrifugation assay was used to determine cell adhesion under an applied detachment force. Binding of EGF was found to significantly increase cell numbers and coverage across the surfaces at 5 days of culturein vitro. Immunofluorescence experiments indicate increased expression of fibronectin, laminin, and α6‐integrins on the EGF‐modified surfaces, and expression is localized at the cell‐material interface as observed by confocal microscopy. In accordance with these results, the highest quantity of adherent cells is found on the EGF‐modified subtrates at 5 days of culture. The results provide initial evidence that binding of EGF may be used to improve the epithelialization of and the adhesion of the cells on a polymeric artificial cornea device. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res, 2010
Fast and simple method for the determination of urinary 1‐hydroxypyrene
Authors: Cahours Xavier , Blanchet Maryline , Rey Miguel 
Published: September 2009

AbstractA fast method for the measurement of metabolites of pyrene in urine was improved by HPLC with fluorescence detector using “heart‐cut” technique. This method can quantify the total amount of pyrene metabolites corresponding to glucuronic acid and sulfate conjugates as well as free 1‐OH‐Py. The hydrolyzed biological fluid was directly injected into the chromatographic system, via a column‐switching system. Pre‐treatment and analysis were performed within 0.5 and 9 min, respectively. Enzymatic hydrolysis has been optimized to not exceed 2 h. The best response function, in the 0.2–10 ng/mL range, is the linear regression, bringing simplicity, good accuracy, and low LOQ. The intra‐ and interday precision values were inferior to 1 and 2%, respectively. The proposed method provided a simple, convenient, and practical procedure to determine the level of the main urinary pyrene metabolites in biological samples.
Photo‐Polymerization of Amphiphilic N,O‐diacylated Serine‐Based Monomers in their Micellar States for an Encapsulation
Authors: Tomatsu Itsuro , Hashidzume Akihito , Harada Akira 
Published: September 2009

AbstractThe photo‐polymerization of amphiphilic monomers, two isomers of N,O‐diacylated serine (AM and EM), has been studied. Self‐assembling properties of the monomers were characterized in aqueous media by NMR and fluorescence techniques. These data show that both can form micellar structures by forming hydrophobic cores from both of the polymerizable and alkyl groups. Photo‐polymerizations of AM and EM were performed in their micellar and solution states. In the micellar states, polymerizations proceeded rapidly and reached almost complete conversion within 1 h, while those in DMSO solutions did not. Comparing the polymers obtained, we concluded that EM was more useful for further applications mainly because of the solubility of the resulting polymer. Based on DLS data, the resulting EM‐polymer micelle had a diameter of ca. 20 nm, about ten times larger than the original micelle. Furthermore, preliminary experiments indicated that the micellar state polymerization of EM afforded an encapsulation of pyrene in a stable hydrophobic domain.magnified image
PCL‐Isocyanate: A New, Degradable Macromolecular Synthon for the Synthesis of Polymeric Bioconjugates
Authors: Blanquer Sébastien , Garric Xavier , Coudane Jean 
Published: September 2009

AbstractA new route to poly(ε‐caprolactone) (PCL) conjugates is described. It is based on successive reactions: the formation of a polycarboxylated PCL via an anionic carboxylation of PCL, the activation of the carboxylic acid group via an acyl chloride group, the conversion of the acyl chloride group to an azide group and finally the formation of an isocyanate group by the Curtius rearrangement. The various steps were monitored using FTIR spectroscopy. To exemplify the potential of the method, isocyanated poly(ε‐caprolactone) was reacted with UV–absorbing, model, alcohol‐ and amine‐bearing small molecules that were bound to the PCL skeleton via carbamate or urea bonds, respectively. FTIR spectroscopy, SEC with refractometric/photodiode‐array double detection, and 1H NMR spectroscopy were used to assess the effective binding of the drug models on the polymeric backbone. The thermal transitions of the conjugates were characterized using DSC.magnified image
The Self‐Assembled Structure of the Diblock Copolymer PCL‐b‐P4VP Transforms Upon Competitive Interactions with Octaphenol Polyhedral Oligomeric Silsesquioxane
Authors: Lu Chu‐Hua , Kuo Shiao‐Wei , Chang Wen‐Teng , Chang Feng‐Chih 
Published: September 2009

AbstractThis paper describes the miscibility and self‐assembly, mediated by hydrogen‐bonding interactions, of new block copolymer/nanoparticle blends. The morphologies adopted by the immiscible poly[(ε‐caprolactone)‐block‐(4‐vinyl pyridine)] (PCL‐b‐P4VP) diblock copolymer changes upon increasing the number of competitive hydrogen‐bonding interactions after adding increasing amounts of octaphenol polyhedral oligomeric silsesquioxane (OP‐POSS). Transmission electron microscopy reveals morphologies that exhibit high degrees of long‐range order, such as cylindrical and spherical structures, at relatively low OP‐POSS contents, and short‐range order or disordered structures at higher OP‐POSS contents. Analyses performed using differential scanning calorimetry, wide‐angle X‐ray diffraction, and FT‐IR spectroscopy provide positive evidence that the pyridyl units of the P4VP block are significantly stronger hydrogen‐bond acceptors toward the OH group of OP‐POSS than are the CO groups of the PCL block, thereby resulting in excluded and confined PCL phases.magnified image
Camptocormia as a presentation of generalized inflammatory myopathy
Authors: KUO Sheng‐Han , Vullaganti Mithila , Jimenez‐Shahed Joohi , Kwan Justin Y. 
Published: September 2009

AbstractCamptocormia is an abnormal truncal flexion posture that occurs while walking or standing. It is usually caused by various hypokinetic movement disorders such as Parkinson disease and multiple system atrophy. Myopathy or motor neuron disease can also be infrequent causes of camptocormia. Paraspinous muscle biopsy usually reveals focal myositis, regardless of the etiology of camptocormia. We describe the first case of generalized inflammatory myopathy with prominent camptocormia and proximal muscle weakness. Muscle biopsy of the quadriceps confirmed the diagnosis of polymyositis, and the posture showed modest improvement in response to steroid treatment. Muscle Nerve, 2009
Effect of superficial peroneal nerve fascial penetration site on nerve conduction studies
Authors: Park Geun‐Young , Im Sun , Lee Jong‐In , Lim Seong‐Hoon , Ko Young‐Jin , Chung Myung‐Eun , Hong Bo‐Young , Kim Hye‐Won 
Published: September 2009

AbstractUsing nerve conduction studies (NCS) and ultrasonography, we sought to determine the stimulation site that corresponds to the site at which the superficial peroneal nerve (SPN) penetrates the fascia and yields the most accurate NCS results. NCS parameters of the SPN sensory nerve action potential (SNAP) were recorded from 37 legs at 14, 12, 9, 7, and 5 cm (S1, S2, S3, S4, and S5, respectively) proximal to the recording electrode, and analyzed by one‐way analysis of variance. SPN penetration sites were visualized by ultrasonography. The mean SNAP amplitude/area (17.2 ± 6.7 μV/9.6 ± 4.6 μV/ms) at S3–S5 differed significantly from that at S1–S2 (11.6 ± 4.7 μV/9.2 ± 4.4 μV/ms) (F = 10.2, P < 0.001; F = 5.09, P = 0.0007). Ultrasonography showed that the SPN became subcutaneous between S3 and S4. Clinical application of these results should help in obtaining more accurate data during electrodiagnostic studies of conditions that involve the SPN. Muscle Nerve, 2010