bluuebunny/crossref_metadata_2025_split huggingface dataset:
Workplace Accommodations and the Labour Force Status of Persons with Disabilities
Authors: Schimmele Christoph , Jeon Sung-Hee , Arim Rubab 
Published: June 2024

Abstract

Purpose
The aim of the study is to examine the role of unmet needs for workplace accommodations (WPA) in the labour force status of persons with disabilities (PWD) aged 25–64 years.
Methods
The study used data from the 2017 Canadian Survey on Disability and multinomial logistic regressions to estimate the predicted probabilities of employment, unemployment, detachment from the labour force, and retirement. Product terms were used to examine if the association between unmet needs for WPA and these employment outcomes depended on severity of disability and age group.
Results
The findings show that the probability of employment was far lower for PWD with unmet needs for WPA than it was for their counterparts without unmet needs, after controlling for disability-related and sociodemographic characteristics. While having more severe disabilities associated with a lower employment rate, this occurred entirely in the context of unmet needs for WPA, as there was no difference between persons with milder and more severe disabilities without unmet needs. Unmet needs for WPA had age-specific consequences and were associated with a higher probability of unemployment and detachment from the labour force among PWDs aged 25–34 years and a higher probability of retirement among PWD aged 55–64 years.
Conclusion
Unmet needs for WPA are a barrier to the employment chances of many PWD and eliminating these needs could increase their inclusion in the labour force.
Denticle rows on larval appendages in twelve species of Phytoseiidae (Parasitiformes: Mesostigmata)
Authors: Ren Fang-Xu , Wei Xin-Ju , Ma Min , Fan Qing-Hai 
Published: June 2024

Abstract

The presence of denticles on appendages such as the palpi and legs is rarely documented in phytoseiid mite larvae. To address this gap, we studied twelve species across six genera of Phytoseiidae: Amblydromalus limonicus, Amblyseius herbicolus, Amblyseius orientalis, Amblyseius taiguensis, Euseius utilis, Neoseiulus benjamini, Neoseiulus californicus, Neoseiulus setarius, Neoseiulus womersleyi, Neoseiulus zwoelferi, Phytoseiulus persimilis and Phytoseius hongkongensis. We identified and described the denticles on the palp, basis capitulum, and specific leg segments of these species, discussing their functional significance.
Simultaneous Functionality of Tamm Plasmon Mode-Based Refractive Index Sensor Across Multiple Photonic Bandgaps
Authors: Sharma Anup Kumar , Srivast Amod Kumar , Maji Partha Sona , Kumar Samir 
Published: June 2024

Abstract

In this work, a refractive index sensor based on Tamm plasmons mode is proposed, capable of concurrent functionality across diverse photonic bandgaps. The proposed sensor structure consists of an analyte cavity sandwiched between a one-dimensional photonic crystal of SiO2/TiO2 and a thin metal film. Tamm resonances are observed within different photonic bandgaps. The functioning principle of this optical sensor relies on altering the refractive index of the analyte, resulting in a shift in either the transmission or reflection spectrum. The study reveals that the resonance wavelength demonstrates a linear increase with the rise in the analyte's refractive index. The study reveals that simultaneous utilization of Tamm Plasmon sensors across multiple bandgaps enables multiplexed sensing, where we can detect multiple analytes or parameters in parallel. Tamm resonance-based sensors, notable for their main advantage of prism-free coupling, offer a compelling alternative to other optical sensors like surface plasmon resonance-based sensors.
Active-Bromide and Surfactant Synergy for Enhanced Microfouling Control
Authors: Shukla Sudhir K , Rao T. Subba , Mohan T. V. Krishna 
Published: June 2024

Abstract

Biofilms are structured microbial communities encased in a matrix of self-produced extracellular polymeric substance (EPS) and pose significant challenges in various industrial cooling systems. A nuclear power plant uses a biocide active-bromide for control of biological growth in its condenser cooling system. This study is aimed to evaluate the anti-bacterial and anti-biofilm efficacy of active-bromide against planktonic and biofilm-forming bacteria that are commonly encountered in seawater cooling systems. The results demonstrated that active-bromide at the concentration used at the power plant (1 ppm) exhibited minimal killing activity against Pseudomonas aeruginosa planktonic cells. Biofilm inhibition assays using Staphylococcus aureus and P. aeruginosa also revealed limited efficacy at 1 ppm concentration. However, the addition of a surfactant, Triton-X 100, in combination with active-bromide displayed a synergistic effect, leading to significant biofilm dispersal of pre-formed P. aeruginosa biofilms. These findings suggest that active bromide alone may be insufficient for microfouling control in the seawater-based condenser cooling system of the power plant. The inclusion of a compatible surfactant that dislodged established biofilms (microfouling) has enhanced the effectiveness of active bromide action.
Effects of Remdesivir on liver enzymes, oxidative stress and Liver histopathology in rats
Authors: Abbasi Mehran Mesgari , Darbani Roya , Rabet Oldouz , Ghorbanihaghjo Amir , Rashtchizadeh Nadereh , Raeisi Sina , Khordadmehr Monireh 
Published: June 2024

Abstract

Background & Aims: Remdesivir (REM) has been widely used to treat subjects affected by COVID-19 due to its broad-spectrum activity. The aim was to assess the REM effect on liver histopathology, enzymes, and alterations in oxidative stress markers.Methods Forty-eight Wistar rats were separated into eight groups as follows: Group A (Control) received normal saline intraperitoneally (IP) for 10 days; Group B (Low-dose REM) received REM (2.8 mg/kg for the first day and 1.4 mg/kg for days 2 to 10, IP); Group C (High-dose REM) received REM (8.5 mg/kg IP for the first 17 days and days 2 to 10); Group D (High-dose REM + DEX (Dexamethasone) + HEP (Heparin) received DEX (7 mg/kg intramuscularly for 10 days) and HEP (333 IU/kg subcutaneously on the first day and 250 IU/kg subcutaneously every 12 hours from day 2 to day 10); Group E (High-dose REM + DEX); Group F (High-dose REM + HEP); Group G (DEX); Group H (HEP). For statistical analysis, non-parametric tests (Kruskal-Wallis H and Mann-Whitney U) were used for pathological lesions (semi-quantitative data) between the different groups, and a p < 0.05 was considered significant.Results There were mild to severe pathological changes in the treated groups, including cell swelling, vascular congestion. Also, the D and G groups showed similar pathological lesions, which were more severe than in other treated groups with a significant difference (p < 0.05).Conclusions Remdesivir causes hepatic toxicity and alterations in oxidative stress markers, and therefore monitoring is required during treatment.
Firewall Log Classification: Leveraging Feature Selection and Stacking Ensemble
Authors: Monfared Amir Hussein Ataei , Borna Keivan 
Published: June 2024

Abstract

Firewall logs can provide valuable information about attempted security breaches and attacks. By classifying these logs, security teams can more easily identify patterns and potential threats, allowing them to take proactive measures to protect their systems. This paper presents a thorough analysis of the various features found in firewall log data. It focuses on selecting the most crucial features using feature selection techniques. The recommended feature sets are then assessed using stacking ensemble XGBoost to demonstrate their suitability. In order to compare the effectiveness of different feature selection techniques, we evaluated at least one member from each technique family using the proposed method. The experimental findings indicate that when Feature Shuffle Random Forest is used in conjunction with the proposed approach, the resulting model is the most accurate, achieving a performance evaluation metric of 99.93\%, signifying exceptional accuracy.
Role of Triply Periodic Minimal Surface Ti6Al4V ELI alloy lattices fabricated by L-PBF method on cell behavior and inflammatory response
Authors: Srimaneep Viritpon , Trachoo Vorapat , Phothichailert Suphalak , Srithanya Supreda Suphanantachat , Mahanonda Rangsini , Norbert Heil , Khrueaduangkham Suppakrit , Promoppatum Patcharapit , Osathanon Thanaphum 
Published: June 2024

Abstract

Triple Periodic Minimal Surface lattices have been introduced to dental and medical devices. Numerous designs of these porous structures have been proposed, but the biomechanical effects of the different topographic lattices are not fully understood. So, this study aimed to examine the cell and inflammatory responses to different lattice designs, including strut-based and surface-based lattices. Human osteoblasts, human umbilical vein endothelial cells, and monocytes were used to evaluate cell proliferation, osteogenic differentiation, and inflammatory response on lattices after surface treatment strategies. Post-surface treatment of chemical etching, besides improving the surface roughness by removing some adhered metal powder, also modulated the surface energy. Lattice design had no significant impact on cell proliferation, but higher cell proliferation was found in post-surface treated lattices, regardless of topographic design. For angiogenesis, there was no difference in the release of pro-angiogenic growth factors between topographic designs or post-surface treatment groups. Moreover, lattices with the post-surface treatment were prone to have lower inflammation phenotype when compared to as-printed lattice, though not in a significant manner. This study suggests that different topographic lattice designs may not have a major impact on bone ingrowth, but post-surface treatment and surface properties of lattice could suppress a macrophage-induced inflammatory response.
Puerarin ameliorates apoptosis and inflammation induced by kidney stones through the PI3K/AKT pathway: Network pharmacology and experimental validation
Authors: Xu Yuexian , Liang Hu , Mao Xike , Song Zhenyu , Shen Xudong , Ge Defeng , Chen Yang , Hou Bingbing , Hao Zongyao 
Published: June 2024

Abstract

Puerarin(PUE), an isoflavonoid extracted from Pueraria root, has anti-apoptotic effects. The objective of this research is to examine the impact of PUE on renal apoptosis and inflammation resulting from renal calculi and to elucidate its mechanism.The approach of network pharmacology and molecular docking was employed to discover potential targets and pathways of PUE. An animal model of calcium oxalate crystal deposition by intraperitoneal injection of glyoxylate and a model of COM-induced human renal tubular epithelial cells (HK2) were used to investigate the pharmacological mechanisms of PUE against apoptosis and inflammation. We used hematoxylin-eosin (H&E) and Periodic Acid-Schiff staining (PAS) to assess the effect of PUE on crystal deposition and damage. The mechanism of PUE was elucidated and validated using Western blotting, histology, and immunohistochemical staining.Network pharmacology findings indicated that the PI3K/AKT pathway plays a crucial role in PUE. We experimentally demonstrate that PUE alleviated COM-induced changes in apoptotic proteins, increased inflammatory indicators and changes in oxidative stress-related indicators in HK2 cells by activating the PI3K/AKT pathway, reduced serum creatinine and urea nitrogen levels in mice caused by CaOx, alleviated crystal deposition and damage, and alleviated apoptosis, oxidative stress and inflammation.Puerarin attenuates renal apoptosis and inflammation caused by kidney stones through the PI3K/AKT pathway.
Current Evidence on Molecular Mechanisms of Andrographolide in Cancer
Authors: Attri Dharam Chand , Dhyani Praveen , Trivedi Vijay Laxmi , Sharma Eshita , Ibrayeva Manshuk , Jantwal Arvind , Sati Priyanka , Calina Daniela , Sharifi-Rad Javad 
Published: June 2024

Abstract:
Cancer, a diverse group of diseases characterized by abnormal cell growth
and the potential to spread throughout the body, accounts for approximately 10 million
deaths globally each year. Current cancer therapies, including chemotherapy, radiation,
and various pharmacological treatments, present several challenges and potential side effects.
It is important to differentiate these conventional methods, which often involve
synthetic drugs, from adjuvant therapies that might be used in conjunction. As a result,
there is an increasing interest in alternative therapies, particularly in agents derived from
natural sources for cancer treatment. Secondary metabolites have shown promise in promoting
the development of new clinical drugs with various anti-cancer mechanisms.
This review focuses on the anti-cancer potential of the novel metabolite Andrographolide,
extracted mainly from Andrographis paniculata. The chemopreventive properties
and the ability to inhibit various signaling pathways across different types of cancers
without side effects posit Andrographolide as a promising natural antitumour agent.
The review identified that Andrographolide inhibits multiple signaling pathways, contributing
to its anti-proliferative, anti-metastatic, and apoptotic effects in various cancers.
The compound's natural origin and lack of adverse side effects make it particularly
attractive as a therapeutic agent. However, further detailed studies are needed to fully understand
its specific mechanisms and potential clinical applications. Andrographolide
presents a compelling option as a natural anticancer agent with the potential to overcome
some limitations of traditional cancer treatments. Its broad spectrum of anti-cancer
activities and absence of side effects highlight its therapeutic potential. The review highlights
that continued research and clinical studies are important for confirming the effectiveness
and safety of Andrographolide in human use, alongside optimizing dosage and
delivery techniques.
Sevoflurane and Propofol Co-affect the Development of Colorectal Cancer by Regulating TM2D1
Authors: Lu Yan , Li Ling , Piao Zongfang , Tan Xinmin , Su Rui 
Published: June 2024

Aims:
Sevoflurane and propofol are the most commonly used anesthetics in surgery.
In this study, we aim to explore and clarify the function of sevoflurane and propofol in colorectal
cancer.

Methods:
Cell counting kit-8, colony formation, western blot, and transwell assays were performed
to determine cell proliferation, apoptosis, ferroptosis, invasion, and migration. We performed
overexpression experiments to detect the underlying molecular mechanism of sevoflurane
and propofol. The genes related to epithelial-mesenchymal transition were measured by
western blot.

Results:
We discovered that sevoflurane and propofol co-treatment exerted more anti-tumor activities
than just sevoflurane or propofol treatment in colorectal cancer cells in vitro. Mechanistically,
our data showed that sevoflurane and propofol-induced apoptosis and ferroptosis and inhibited
cell proliferation, invasion, and migration. Additionally, TM2D1 was considered a target
of sevoflurane and propofol, and TM2D1 overexpression reversed the effect of sevoflurane and
propofol on colorectal cancer cell biology behaviors.

Conclusion:
Our results showed a novel anti-tumor mechanism of sevoflurane and propofol in
colorectal cancer cells, and TM2D1 might be an underlying therapeutic target for treating colorectal
cancer patients.

other:
Our results showed novel anti-tumor mechanism of sevoflurane and propofol in colorectal cancer cells, and TM2D1 might be an underlying therapeutic target for treatment of colorectal cancer patients.
Effects of Oxidative Stress on Serum Metabolism in Acute Pancreatitis Rats Based on Untargeted Metabolomics
Authors: Chen Jinfeng , Meng Nuo , Lei Yu , Feng Yong , Li Yurong , Tang Xiping 
Published: June 2024

Objectives:
Acute pancreatitis(AP) is a common digestive tract disease, often accompanied
by severe metabolic disorders, but there are no specific markers and treatment methods,
and the potential metabolic pathways behind it remain to be explored.

Methods:
Establish mild acute pancreatitis and severe acute pancreatitis models in rats and intervene
with antioxidant NAC. Analyze serum oxidative stress indicators and pathological changes
in pancreatic tissue. In addition, non-targeted metabolomics analysis of serum differential metabolites
between groups was conducted based on the LC/MS system.

Results:
The pathological score of the model group rats increased, and the levels of oxidative
stress factors ROS and MDA significantly increased, while the activity of the antioxidant enzyme
SOD decreased. After NAC intervention, oxidative stress damage in rats was alleviated.
Non-targeted metabolomics experiments suggest significant differences in serum metabolic profiles
among different groups of rats.

Conclusion:
Metabolomics results show that the obtained differential metabolites are expected to
become serum biomarkers for AP.

result:
In the untargeted metabolomics test, we found that there were obvious differences in serum metabolic profiles of rats. The MAP model group was compared with the NC group, we selected 7 significant differential metabolites, including PC, Tuftsin, etc. The comparison of the MAP + NAC intervention group with the MAP group yielded a total of five significantly differential metabolites, including 20-Deoxynarasin, VPGPR Enterostatin and 12-Ketoporrigenin et al. Compared with the SO group, 23 metabolites with significant differences were screened out in SAP group. The comparison of SAP + NAC intervention group with SAP model group selected 10 significantly different metabolites, including lipids (PC, PE), Physalolactone B, etc.. These metabolites are involved in complex pathophysiological processes such as oxidative stress and inflammation, involving various metabolic pathways such as glycerophospholipid metabolism, arachidonic acid metabolism, and pentose and glucuronate interconversions.
Rheum khorasanicum Decreases Migration and Induces Apoptosis in the MDA-MB-231 Breast Cancer Cell Line
Authors: Mehrabani Mitra , Miri Zahra , Juybari Kobra Bahrampour , Najafi Rezvan , Goki Maryamossadat Mirtajaddini , Aminizadeh Najmeh , Nematollahi Mohammad Hadi , Vasei Saeede , Mehrabani Mehrnaz , Amirkhosravi Arian 
Published: June 2024

Background:
Rheum khorasanicum is a medicinal plant that belongs to the Polygonaceae
family. This family is well-known for its anticancer activities.

Objective:
Due to the limited studies on the anticancer activity of R. khorasanicum, the present study
aimed to evaluate the apoptotic effect of this medicinal plant on MDA-MB-231 cells as a model for
an aggressive triple-negative breast cancer that has a lower treatment option.

Methods:
R. khorasanicum root was collected in April, 2021 from Neyshabur, Iran, and its hydroalcoholic
extract was prepared using the maceration method. The High-Performance Thin-Layer
Chromatography (HPTLC) assay was used to determine the main ingredients of the extract. The
viability and apoptosis of the cells were evaluated by WST-1 and the annexin-V/PI dual staining
assay, respectively. The scratch assay was used to assess the migratory potential of cancer cells, and
the Western blotting test was employed for determining the expression of Bcl-2, Bax, cleaved caspase-
3, cleaved caspase-7, and procaspase-7 proteins involved in the apoptotic pathway.

Results:
The yield of extract from R. khorasanicum root was 56.8 ± 11.1%. The HPTLC analysis
indicated that emodin, gallic acid, and epigallocatechin were pharmacologically active compounds
isolated from the hydroalcoholic extract of R. khorasanicum root. The extract showed a significant
toxic effect on MDA-MB-231 cells up to 60 μg/mL concentration. R. khorasanicum root extracts
also inhibited the migratory potential of MDA-MB-231 at concentrations ≥ 60 μg/mL. The plant root
extract at concentrations of 60 and 100 μg/mL significantly increased the Bax/Bcl-2 ratio cleaved
caspase-3, cleaved caspase-7/ procaspase-7 protein levels compared to the nontreated cells.

Conclusion:
Our findings demonstrated that the hydroalcoholic extract of R. khorasanicum efficiently
triggered the apoptosis of MDA-MB-231 cells as a suitable model for aggressive triple-negative
breast cancer, possibly by decreasing their migratory potential and stimulating the apoptotic signaling
pathway.
Variations in the Solar Modulation Parameter Over the Last 9.5 Thousand
Years and the Tilt of the Geomagnetic Dipole
Authors: Vasiliev Sergey S. , Dergachev Valentin A. 
Published: June 2024

Background:
Calculations of the solar modulation parameter (Φ) over the past millennia
typically use the relationship between the production rate of cosmogenic isotopes, the earth's
dipole moment, and the magnitude of Φ. The cosmogenic isotopes 14C and 10Be are typically used
in these studies. When studying solar modulation, the cyclic change in dipole tilt is usually not
taken into account, which affects estimates of past solar activity.

Methods:
Tree rings are a reliable basis for obtaining a radiocarbon time scale (IntCal13). However,
determining the concentration of 14C in tree rings is a difficult and controversial task. The
time scale derived from the 10Be production rate simulation (GICC05) is less reliable. Nevertheless,
there is a way to combine the accuracy of the radiocarbon time scale with the reliability of
estimates of the 10Be production rate. This method is the synchronization of the radiocarbon and
beryllium-10 series.
We have selected the most relevant methods for calculating the solar modulation parameter Φ for
the Holocene. When calculating Φ, 10Be data synchronized with 14C data were used. The latest
data on the earth's dipole moment were considered. Empirical Mode Decomposition (EMD) was
used in the analysis of Φ.

Results:
It has been shown that the first two decomposition modes are oscillating components
with periods of 710 and 208 years, the amplitudes of which increase with time, reaching a maximum
of 2500 BP. From contemplation, it follows that the 710-year oscillations are apparently
caused by fluctuations in the tilt of the earth's dipole. After excluding the EMD component associated
with the 710-year cyclicity, a corrected series was obtained for the solar modulation parameter,
free from the influence of changes in the tilt of the magnetic dipole.

Conclusion:
The rate of formation of cosmogenic radionuclides depends on the intensity of penetration
of Galactic Cosmic Rays (GCRs) into the earth's atmosphere. Before reaching earth, GCRs
must cross the heliosphere, where they are exposed to solar modulation. Adequate consideration
of solar modulation parameters is important for the correct interpretation of the rate of production
of cosmogenic isotopes and solar activity.