bluuebunny/crossref_metadata_2025_split huggingface dataset:
The socio‐economic burden of H1‐antihistamine‐refractory chronic spontaneous urticaria in Germany
Authors: Augustin Matthias , Beier Dominik , Branner Jennifer , Häckl Dennis , Hampel Regina , Kramps Thomas , Kurzen Hjalmar , Lintener Hannah , Melzer Nima , Müller Malina , Staubach Petra , Schwichtenberg Uwe , Termeer Christian , Zink Alexander , Nathan Petra , Maurer Marcus 
Published: May 2024

AbstractBackground and Study AimData from the AWARE study (A Worldwide Antihistamine‐Refractory chronic urticaria patient Evaluation) illustrate a substantial disease burden in German patients with H1‐antihistamine (‐H1‐AH)‐refractory chronic spontaneous urticaria (CSU). Detrimental effects on patients' quality of life, poor disease control and impairment in the ability to work and perform other daily activities are reported. Based on these findings, this study aims to quantify the epidemiological and socio‐economic burden of H1‐AH‐refractory CSU in Germany.MethodsTo determine the epidemiological burden of H1‐AH‐refractory CSU, the age‐ and gender‐specific prevalence of CSU and the proportion of H1‐AH‐refractory patients in Germany anonymized data from the InGef research database have been used. In a second step, the socio‐economic burden in terms of lost numbers of hours in paid and unpaid work was calculated by extrapolating the age‐ and gender‐specific work productivity and activity impairment (WPAI) observed in AWARE to the H1‐AH‐refractory CSU population in Germany. Finally, productivity losses in paid and unpaid work were monetized using the human capital and the friction cost approach respectively. Moreover, socio‐economic burden was calculated depending on symptom control of the patients (measured by urticaria control test [UCT]).ResultsIn Germany, over 203,000 patients (20 years or older) had H1‐AH‐refractory CSU in 2018. The avoided lost paid and unpaid work hours attributable to H1‐AH‐refractory CSU summed up to over 100 million. Overall, the socio‐economic burden of H1‐AH‐refractory CSU in monetary terms was evaluated at € 2.2 billion and the majority of this was due to unpaid work loss. Patients with poor disease control, as indicated by UCT score < 12, were more likely to suffer from high impairment than patients with controlled disease, resulting in a higher socio‐economic burden.ConclusionsThe results of our analyses picture the substantial socio‐economic burden of H1‐AH‐refractory CSU and therefore the tremendous impact it has on daily lives of individuals and society overall.
Temporal declines in fecundity: A study of southern Gulf of St. Lawrence Atlantic herring (Clupea harengus) and implications for potential reproductive output
Authors: Burbank Jacob , McDermid Jenni L. , Turcotte François , Sylvain François‐Étienne , Rolland Nicolas 
Published: May 2024

AbstractIndividuals must reproduce to survive and thrive from generation to generation. In fish, the fecundity of individuals and estimates of total reproductive output are critical for evaluating reproductive success and understanding population dynamics. Estimating fecundity is an onerous task; therefore, many populations lack contemporary estimates of fecundity and size‐fecundity relationships. However, reproductive dynamics are not static in time; therefore, it is important to develop contemporary fecundity estimates to better inform conservation and management action. To highlight the importance of contemporary fecundity estimates, we examined the fecundity of southern Gulf of St. Lawrence (sGSL) spring and fall spawning Atlantic herring in 2022, developed size‐fecundity models, and compared these to historical fecundity estimates and models. Our results suggest that the average fecundity of sGSL spring and fall herring has undergone a substantial temporal decline of approximately 47% and 58%, respectively, since the 1970s and 1980s. The size‐fecundity relationships for fall spawning herring have shifted, with fish of a given size exhibiting lower fecundity in 2022 compared to the 1970s. Alternatively, the size‐fecundity relationships for spring spawning herring have remained relatively static. Furthermore, simulations highlighted a substantial reduction in potential reproductive output in 2022 compared to 1970 of approximately 32% and 68% for spring and fall spawners, respectively, based on a fixed number of mature females, which may have negative implications for stock rebuilding. Overall, our study provides support for periodic estimates of fecundity in fish populations to better understand temporal changes in reproductive and population dynamics.
Technology‐enhanced mindfulness‐based collaborative social reasoning to improve adolescents' social–emotional competencies
Authors: Nagpal Manisha , Lin Tzu‐Jung , Park Haeun , Anderman Eric , Bihari Thomas , Madrid Leon , Ford Jodi , Subramaniam Balachundhar 
Published: May 2024

AbstractThis study reports the preliminary efficacy of an innovative school‐based, technology‐enhanced social–emotional learning program called “mindfulness‐based collaborative social reasoning” (MBCSR) for middle school students. MBCSR was developed by an interdisciplinary team of educational psychologists, mindfulness researchers, computer scientists, and health experts. We integrated the strengths of contemplative approaches, collaborative small group discussions, learning technology, and multidimensional assessments of students' social–emotional outcomes. Using a quasi‐experimental design, the study was implemented in four sixth‐grade English language arts classrooms (2 experimental and 2 business‐as‐usual control; N = 74) in a public middle school in the Midwest of the United States. It was co‐implemented by researchers and teachers, with sessions occurring for 45 minutes, once per week, for 8 weeks. The MBCSR group showed greater self‐efficacy for using Upa‐yoga and mindful breathing to regulate their emotions and behaviors ( = .13), and lower externalizing ( = .07) and bullying behaviors ( = .09) at the posttest compared to the control group, after controlling for baseline differences. Students in the experimental group overall showed positive and relaxed emotional and physiological states during the sessions. There were no significant differences between the two groups in mindfulness, emotional regulation, and social skills. This program sets an example for integrating social–emotional learning and academic learning into students' daily content instruction.
Electrophysiological Evidence for a Whorfian Double Dissociation of Categorical Perception Across Two Languages
Authors: Casaponsa Aina , García‐Guerrero M. Acebo , Martínez Alejandro , Ojeda Natalia , Thierry Guillaume , Athanasopoulos Panos 
Published: May 2024

AbstractTaza in Spanish refers to cups and mugs in English, whereas glass refers to different glass types in Spanish: copa and vaso. It is still unclear whether such categorical distinctions induce early perceptual differences in speakers of different languages. In this study, for the first time, we report symmetrical effects of terminology on preattentive indices of categorical perception across languages. Native speakers of English or Spanish saw arrays of cups, mugs, copas, and vasos flashed in streams. Visual mismatch negativity, an implicit electrophysiological correlate of perceptual change in the peripheral visual field, was modulated for categorical contrasts marked in the participants’ native language but not for objects designated by the same label. Conversely, P3a, an index of attentional orienting, was modulated only for missing contrasts in the participants’ native language. Thus, whereas native labels influenced participants’ preattentive perceptual encoding of objects, nonverbally encoded dissociations reoriented their attention at a later processing stage.
Lipid turnover through lipophagy in the newly identified extremophilic green microalga Chlamydomonas urium
Authors: Pérez‐Pérez María Esther , Mallén‐Ponce Manuel J. , Odriozola‐Gil Yosu , Rubio Alejandro , Salas Joaquín J. , Martínez‐Force Enrique , Pérez‐Pulido Antonio J. , Crespo José L. 
Published: May 2024

Summary

Autophagy is a central degradative pathway highly conserved among eukaryotes, including microalgae, which remains unexplored in extremophilic organisms. In this study, we described and characterized autophagy in the newly identified extremophilic green microalga Chlamydomonas urium, which was isolated from an acidic environment.

The nuclear genome of C. urium was sequenced, assembled and annotated in order to identify autophagy‐related genes. Transmission electron microscopy, immunoblotting, metabolomic and photosynthetic analyses were performed to investigate autophagy in this extremophilic microalga.

The analysis of the C. urium genome revealed the conservation of core autophagy‐related genes. We investigated the role of autophagy in C. urium by blocking autophagic flux with the vacuolar ATPase inhibitor concanamycin A. Our results indicated that inhibition of autophagic flux in this microalga resulted in a pronounced accumulation of triacylglycerols and lipid droplets (LDs). Metabolomic and photosynthetic analyses indicated that C. urium cells with impaired vacuolar function maintained an active metabolism. Such effects were not observed in the neutrophilic microalga Chlamydomonas reinhardtii.

Inhibition of autophagic flux in C. urium uncovered an active recycling of LDs through lipophagy, a selective autophagy pathway for lipid turnover. This study provided the metabolic basis by which extremophilic algae are able to catabolize lipids in the vacuole.
Women's perspectives on mHealth behavior change interventions for the management of overweight, obesity, or gestational diabetes: A qualitative meta‐synthesis
Authors: McGovern Liz , O'Toole Laura , Houshialsadat Zeinab , O'Reilly Sharleen L. 
Published: May 2024

SummarymHealth interventions play an increasingly important role in health behavior change for gestational diabetes or peripartum obesity management. This qualitative systematic review and meta‐synthesis aims to explore women's perceptions of mHealth behavior change interventions for gestational diabetes and/or overweight/obesity management during pregnancy and the postpartum period. Cumulative Index of Nursing and Allied Health Literature (CINAHL), Cochrane, Excerpta Medica Database (EMBASE), Medical Literature Analysis and Retrieval System Online (MEDLINE), and Psychological Information Database (PsycINFO) databases were searched using a Sample, Phenomenon of Interest, Design, Evaluation and Research type (SPIDER) concept framework through to February 2024. Included studies were quality assessed using the Critical Appraisal Skills Programme checklist. Study findings were evaluated using reflexive thematic analysis and GRADE‐Confidence in the Evidence from Reviews of Qualitative Research (CERQual) checklist. We identified 29 studies, representing 604 women's views from one upper middle‐income and nine high‐income countries. Two themes were generated: mHealth as a supportive tool; and mHealth as a personalizable tool. Women highlighted the importance of self‐monitoring, information trustworthiness, peer support, motivational tools (goal setting, risk awareness, and problem solving) and convenience in achieving behavior change using mHealth technology. They suggest mHealth programs incorporate these elements to support user engagement and improved health outcomes. Understanding what women want as mHealth users is particularly important for effective interventions in gestational diabetes, weight management, and chronic disease prevention. Creating a better, more woman‐centered experience by addressing central engagement issues should result in improved maternal health outcomes.
The topical azithromycin meibomian gland dysfunction survey: The effect of topical azithromycin on signs and symptoms of meibomian gland dysfunction
Authors: Jarvis Ian , McCullough Sara , Jarvis John 
Published: May 2024

AbstractIntroductionThe aim of this study was to assess the long‐term effects of topical azithromycin on signs, symptoms and self‐management of meibomian gland dysfunction (MGD).MethodsForty participants were assessed for MGD and its effect on the fluorescein tear break‐up time (FTBUT). Participants were treated with topical azithromycin twice daily for 2 weeks and then once daily for a further 2 weeks. One year after treatment, 31 participants completed a survey assessing pre‐ and post‐treatment effect on symptoms, lifestyle and self‐treatment methods.ResultsFollowing treatment, there was a significant reduction in MGD grading from a median of grade 2 to grade 0 (z = 4.40, p < 0.0001) and an increase in FTBUT from a median of 3–8 s (z = 4.75, p < 0.0001). One year afterwards, the survey showed a significant improvement in symptoms (sensitivity to light, grittiness, burning, blurred vision, all p < 0.03) and reduction in required self‐treatments (lid wipes, tear substitutes, both p < 0.03). There was also a reduced impact on lifestyle (reading, night driving, computer use and watching television, all p < 0.0001) and in all environmental conditions (all p < 0.0001).ConclusionsThis study confirms the positive effect of topical azithromycin on MGD and shows it has a long‐term impact on symptoms, self‐treatment methods and lifestyle. This has implications for both chair time and healthcare costs when managing patients with MGD. Pending further clinical trials in a larger population with different demographics, topical azithromycin should be considered by all eyecare practitioners as a viable pharmacological treatment when managing MGD.
Plant dispersal in the Devonian world (c. 419–359 Ma)
Authors: Liu Bing‐Cai , Wang Kai , Bai Jiao , Wang Yao , Huang Bing , Xu Hong‐He 
Published: May 2024

AbstractDispersal, whether active or passive, plays a crucial role in biogeography by facilitating the movement of propagules away from their original location. Botanical geographical zonation, resulting from the co‐evolution of plants and their environment, has been established since the remarkable plant diversification during the Devonian Period (c. 419–359 Ma). However, a significant knowledge gap exists in understanding plant dispersal between living and fossil organisms due to the rarity of opportunities for tracing plant dispersal in geological history. In this study, we present evidence of two plant dispersal routes and verify their occurrence through the examination of geographical zonation, changes in plant diversity, and latitudinal and longitudinal gradients during the Devonian. We analyse global occurrence data from widely‐distributed and extensively‐studied Devonian plants. The two dispersal routes, namely clockwise and anticlockwise, connect the South China and Euramerica–Siberia realms. These routes clearly demonstrate inland and inter‐land dispersal models, closely linked to Devonian sea–land topography and dispersal vectors such as wind and ocean currents. Moreover, these models probably apply to all Devonian plants. Our comprehensive synthesis of plant dispersal in deep time reveals that propagule diversity and dispersal vectors have progressively increased and become more complex over time, facilitating plant colonization and diversity changes. Importantly, our study unveils the dispersal models of fossil plants, demonstrating the equivalent models observed in extant plants that have been established since the Devonian Period.
Field response and genetic variability of elite spring bread wheat (Triticum aestivum L.) genotypes for septoria tritici blotch under natural infection in Northwest Ethiopia
Authors: Kassie Molla Mekonnen , Abebe Tiegist Dejene , Abate Desta Ermias , Aseress Tazebachew , Tadesse Wuletaw 
Published: May 2024

AbstractFungal diseases cause significant yield loss to wheat production. Septoria tritici blotch (STB), caused by the ascomycete fungus Zymoseptoria trtici, is one of the major fungal diseases affecting wheat production worldwide. In Ethiopia, STB is a severe problem that causes significant yield loss in high and mid‐altitude wheat‐growing areas. The use of resistant varieties is one of the sustainable disease management strategies, particularly for resource‐poor farmers in developing countries. Two hundred and fifty bread wheat genotypes were evaluated to identify septoria tritici resistant genotypes and estimate the extent of genetic variability for resistance to STB and other economically important traits using alpha lattice design under natural infestation in two STB hotspot environments. Analysis of variance revealed highly significant differences among genotypes, environment, and genotype × environment interaction for all traits measured. The genetic coefficient of variance was lower than the phenotypic coefficient of variance for all traits studied, and both test environments showed the influence of the environment on trait expression. High and moderate heritability values were observed for the septoria disease severity parameters, indicating that the STB resistance trait was less influenced by the environment. The days to heading and plant height were inversely correlated with disease severity. This suggests that genotypes with tall plant height and long maturity period could be resistant to septoria tritici blotch through escape mechanisms. Four of the genotypes, namely, G‐215, G‐255, G‐257, and G‐258, were found to be resistant across all locations. These and other promising genotypes will be used in future breeding programmes to select or develop high‐yielding and STB‐resistant bread wheat genotypes that can be deployed in septoria tritici blotch‐prone areas. Highly susceptible genotypes will also be used as controls for STB resistance breeding programmes.
Mate value discrepancies and mate retention behaviors: A cubic response surface analysis
Authors: Young Gracynn , Zeigler‐Hill Virgil , Ross Jessica 
Published: May 2024

AbstractThis study used cubic polynomial regression with response surface analysis to examine the associations that mate value discrepancies (i.e., the difference between an individual's self‐reported mate value and their perceptions of their partner's mate value) had with mate retention behaviors performed by the individual and their perceptions of the mate retention behaviors performed by their partner. The sample included 1083 undergraduates, and the results revealed a congruence effect such that participants who perceived themselves and their romantic partners to have similarly low levels of mate value reported high levels of cost‐inflicting behaviors by themselves and their partners. There was also a curvilinear association that emerged for mate value discrepancies such that individuals who perceived themselves to have higher levels of mate value than their partners reported higher levels of cost‐inflicting behaviors by themselves and their romantic partners. These results demonstrate how cubic response surface analysis can allow for a better understanding of the connections that mate value discrepancies have with outcomes in romantic relationships.
Pitchfork bifurcation along a slow parameter ramp: Coherent structures in the critical scaling
Authors: Goh Ryan , Kaper Tasso J. , Scheel Arnd 
Published: May 2024

AbstractWe investigate the slow passage through a pitchfork bifurcation in a spatially extended system, when the onset of instability is slowly varying in space. We focus here on the critical parameter scaling, when the instability locus propagates with speed , where is a small parameter that measures the gradient of the parameter ramp. Our results establish how the instability is mediated by a front traveling with the speed of the parameter ramp, and demonstrate scalings for a delay or advance of the instability relative to the bifurcation locus depending on the sign of , that is on the direction of propagation of the parameter ramp through the pitchfork bifurcation. The results also include a generalization of the classical Hastings–McLeod solution of the Painlevé‐II equation to Painlevé‐II equations with a drift term.
Prevalence of human herpesvirus in plasma and saliva of cirrhotic patients: A pilot study
Authors: Bueno Marinho Gabriella , Bertoldi Franco Juliana , Tenório Jefferson R. , Silva Andrade Natália , Zerbinati Rodrigo Melim , Medina Janaína B. , Pérez‐Sayáns Mário , Braz‐Silva Paulo Henrique , Ortega Karem L. 
Published: May 2024

AbstractAimsThe objective of this study was to identify the presence of human herpesvirus (HHV) in the plasma and saliva of hepatic‐cirrhosis patients and correlate it with clinical data and laboratory tests. This is a pilot, observational, and cross‐sectional study.Methods and resultsSpecimens of plasma and saliva from 72 cirrhotic individuals were analyzed by means of polymerase chain reaction. The patient population had a mean age of 54.84 years old (SD ± 10) and was 70% males (51/72). Approximately 47% (n = 34) of the patients had leukopenia and HHV was not identified in the plasma specimens. The main species of HHV identified in the saliva were HHV‐7 (n = 42, 62%) and Epstein‐Barr virus (EBV) (n = 30, 41%). Moreover, there was a significant decrease in the total number of leukocytes and lymphocytes in saliva containing EBV (P = .038 and P = .047, respectively).ConclusionThe results show that the presence of EBV in the saliva of cirrhotic patients was correlated with their circulating immune status. It may be possible that the immune dysfunction displayed by the cirrhotic patients plays a role in the shedding of EBV into saliva.
Schemas, rounding, and comparison, oh my!: Supporting students with money word problems
Authors: Bouck Emily C. , Cox Sarah , Long Holly , Reiley Sarah 
Published: May 2024

AbstractPurchasing skills are important for students with disabilities, including those with support needs, to access their community and future employment opportunities independently. However, making purchasing and money decisions can involve a variety of mathematics skills like rounding, estimation, and price comparison. Schematic diagrams and schema‐based instruction are researcher‐supported interventions used to support students with disabilities in solving word problems related to purchasing and other money related skills. Researchers in this study explored the use of schematic instruction for teaching rounding, estimating, and number comparison skills to aid students in making purchasing decisions. Two of the three students in the study met the mastery criteria of 100% independence for two consecutive sessions; the third did not. The two students who met mastery criteria also successfully generalized the skills to a simulated shopping experience. Overall, the results suggest the value of schematic diagram but also indicate the need to provide more supports and scaffolds to support some students with disabilities in solving multi‐step word problems.
NOMINALIZED CLAUSES AND DISCOURSE‐GIVENNESS: EXPERIMENTAL EVIDENCE FROM RUSSIAN*
Authors: Knyazev Mikhail , Rudaleva Ekaterina 
Published: May 2024

AbstractIn a seminal paper, Kiparsky & Kiparsky (1970) proposed a two‐way correspondence between presuppositionality of clauses and nominal structure. The proposal remains highly relevant to current research (a.o. Kastner 2015, Bochnak & Hanink 2022), despite the existence of counterexamples in both directions. In this paper, we examine Russian nominalized clauses to show that presuppositionality is indeed neither necessary nor sufficient for nominalization. However, instead of completely discarding the correspondence between presuppositionality and nominalization, we argue for a weaker “preference” hypothesis, whereby presuppositional, or discourse‐given, contexts are associated with a higher likelihood of nominalization compared to discourse‐new contexts. We provide support for the preference hypothesis based on four experimental studies, a forced‐choice and a givenness‐rating study using matrix negation as a proxy for givenness and a forced‐choice and a sentence completion study directly manipulating the discourse context. We suggest a tentative explanation for the preference hypothesis in terms of definiteness/familiarity marking.