bluuebunny/crossref_metadata_2025_split huggingface dataset:
COPI-mediated membrane trafficking is required for cytokinesis inDrosophilamale meiotic divisions
Authors: Kitazawa Daishi , Yamaguchi Masamitsu , Mori Hajime , Inoue Yoshihiro H. 
Published: May 2012

SummaryThe coatomer protein complex, COPI, mediates retrograde vesicle transport from the Golgi apparatus to the ER. Here, we investigated the meiotic phenotype of Drosophila melanogaster spermatocytes expressing dsRNA of 52 genes encoding membrane-trafficking-related factors. We identified COPI as an essential factor for male meiosis. In Drosophila male meiotic divisions, COPI is localized in the ER–Golgi intermediate compartment of tER–Golgi units scattered throughout the spermatocyte cytoplasm. Prior to chromosome segregation, the vesicles assemble at the spindle pole periphery through a poleward movement, mediated by minus-end motor dynein along astral microtubules. At the end of each meiotic division, COPI-containing vesicles are equally partitioned between two daughter cells. Our present data strongly suggest that spermatocytes possess a regulatory mechanism for equal inheritance of several types of membrane vesicles. Using testis-specific knockdown of COPI subunits or the small GTPase Arf or mutations of the γCOP gene, we examined the role of COPI in male meiosis. COPI depletion resulted in the failure of cytokinesis, through disrupted accumulation of essential proteins and lipid components at the cleavage furrow region. Furthermore, it caused a reduction in the number of overlapping central spindle microtubules, which are essential for cytokinesis. Drosophila spermatocytes construct ER-based intracellular structures associated with astral and spindle microtubules. COPI depletion resulted in severe disruption of these ER-based structures. Thus, we propose that COPI plays an important role in Drosophila male meiosis, not only through vesicle transport to the cleavage furrow region, but also through the formation of ER-based structures.
Invasive lobular carcinoma of the breast: MRI pathological correlation following bilateral total mastectomy
Authors: Stivalet Aude , Luciani Alain , Pigneur Frederic , Dao Thu Ha , Beaussart Pauline , Merabet Zahira , Perlbarg Julie , Meyblum Evelyne , Baranes Laurence , Calitchi Elie , Lepage Christophe , Belkacemi Yazid , Lagrange Jean-Leon , Lantieri Laurent , Rahmouni Alain 
Published: May 2012

Background Invasive lobular carcinoma (ILC) is more often multifocal and bilateral than invasive ductal carcinoma. MRI is usually recommended for detection of all ILC sites. The performance of known diagnostic breast MRI criteria for ILC characterization has not been evaluated to date using bilateral mastectomy specimens as gold standard. Purpose To determine the value of BI-RADS 2006 MRI criteria for ILC detection and characterization, using pathological examination of bilateral mastectomy specimens as the reference standard. Material and Methods Between 2004 and 2007, we retrospectively included all patients with pathologically documented ILC referred to our institution for bilateral mastectomy and preoperative bilateral breast MRI. The location, diameter, and characteristics (BI-RADS) of all lesions were compared with pathological findings. The sensitivity and positive predictive value of bilateral breast MRI for the diagnosis of ILC were calculated. Association of MRI BI-RADS categorical variables and characterization of ILC were assessed (Fisher exact test). Results Among 360 patients treated for ILC in 2004–2007, 15 patients qualified for this study. Thirty-one ILC foci were found on pathological examination (30 ipsilateral and 1 contralateral tumor; mean diameter 23 mm; range 2–60 mm) and all were identified on MRI, with 90% of masses and 10% non-mass-like enhancements; MRI features significantly associated with ILC included absence of smooth margins ( P = 0.02) and rim-shaped enhancement ( P = 0.039). Enhancement kinetics of the 31 foci were evenly distributed among wash-out, plateau, and persistent profiles. Eleven additional lesions were seen on MRI, mainly corresponding to fibrocystic disease; 91% presented as masses and 9% had a wash-out profile. Conclusion Based on the 2006 BI-RADS criteria, breast MRI shows a high sensitivity for ILC detection, at the expense of a 26% false-positive rate, suggesting that a pathological proof by US- or MR-guided biopsy is required in case of suspicious MRI images in this context.
Planning a Pharmacy-Led Medical Mission Trip, Part I: Focus on Medication Acquisition
Authors: Brown Dana A , Ferrili Mary J 
Published: May 2012

This article, focusing on medication acquisition and formulary development, is the first in a 4-part series on pharmacist-led medical mission trips. The second article, “Servant Leadership and Team Dynamics,” examines the concept of servant leadership as part of medical missions’ efforts and provides suggestions for team building, both before and during the mission trip. Part 3, “Development and Implementation of an Elective Medical Missions Advanced Pharmacy Practice Experience (APPE) Rotation,” focuses on developing an elective APPE for international and domestic medical missions, including provision of products. Part 4, “An Exploratory Study of Student Experiences,” is an evaluation of data collected from both APPE and non-APPE student participants on Gregory School of Pharmacy mission trips during the summer of 2011. Specifically it examines the issue of professionalism and the personal impact that mission trips may have on pharmacy students. Pharmacists can be involved in many functions of the medical mission team. Particularly, they can play a large role in formulary development, acquisition of medications, and organization of medications before and during the mission trip. Important factors for consideration in formulary development and logistical planning include the group's budget; importation laws and regulations of the country being visited; transportation and storage of medications and supplies; disease states anticipated; whether controlled substances wilt be included; whether medical or surgical procedures will be provided; age distribution and languages of the population to be treated; whether sample medications will be used; handling of unused medications and supplies after the trip; and considerations of the population's cultural beliefs. Various organizations are available to provide medications for medical mission efforts at little to no cost, and knowledge of these organizations will help to facilitate the process of medication acquisition. Additionally, pharmacists can provide insight regarding the logistical set-up and workflow considerations during the mission experience.
The Relationships Among Different Types of Social Support Accessed by Traumatic Spinal Cord Injury Survivors
Authors: Murphy Gregory C. , O'Hare Mary Alice , Wallis Lara 
Published: May 2012

AbstractAim: This exploratory study examined the relationships among different types of social support accessed by patients with traumatic spinal cord injury (SCI). Method: Using a cross-sectional study design, 20 SCI patients of workforce age discharged from the Royal Talbot Rehabilitation Hospital, Melbourne, Australia during 2007 were assessed on a range of demographic, injury and social support variables. Results: Higher quality interactions (i.e., actual social support) were significantly associated with greater social integration (i.e., structural social support) and higher perceived social support. However, community integration and social integration, which measure different aspects of structural social support, were essentially unrelated. Conclusions: Actual social support influences perceived social support and social integration. Theoretically, these results suggest that actual social support influences the two main opposing models that explain the relationship between social support and wellbeing: the stress-buffering model (for perceived social support) and the main-effects model (for structural social support). From a research perspective, the use of well-defined types of social support, and psychometrically sound measures, is critical for assessing the influence of social support on rehabilitation outcomes. To effectively match rehabilitation efforts with SCI survivors' needs, future research should examine which types of social support best predict particular rehabilitation outcomes.
Competencies and Tasks of Disability Management Professionals in Germany
Authors: Niehaus Mathilde , Marfels Britta 
Published: May 2012

AbstractDemographic changes are transforming Germany's working environment. A shrinking and aging workforce is having to cope with rising market requirements for skilled labour. As the risk of occupational disability rises with age, lawmakers have introduced a number of legislative changes to sustain workers' ability to work as long as possible. Another important step in this direction was the introduction of a training program to become a Certified Disability Management Professional (CDMP), based on the Canadian model and driven by the German Social Accident Insurance (DGUV). International scientific research has long recognised the importance of professional counselling and support for successful vocational rehabilitation of sick and disabled people. In Germany, however, there has been a lack of studies investigating which competencies disability managers need for their work or whether their training is adequate. The present study fills this gap. 217 disability managers and other vocational rehabilitation professionals were asked about their tasks and the competencies required for their work. Two important areas of responsibility were identified: work with the client, on the one hand, and organisational and managerial tasks on the other. This represents a lower degree of specialisation than that found in related American or Australian studies. Possible reasons for these differences are discussed.
Romantic Partner Behaviours as Social Context: Measuring Six Dimensions of Relationships
Authors: Ducat Wendy H. , Zimmer-Gembeck Melanie J. 
Published: May 2012

AbstractA new measure, Partner Behaviours as Social Context (PBSC), was developed and tested in two studies (N = 215, N = 316) and tested as a correlate of psychological wellbeing in a third (N = 157). Self-Determination Theory (Deci & Ryan, 2000) and related research has suggested that there are six important dimensions of partner behaviours, which should be associated with individual psychological need fulfilment, wellbeing and development. Three of these dimensions are positive, including warmth, or provision of love/affection; autonomy support, or supporting a partner's decisions; and structure, or being consistent and reliable. Three of these dimensions are negative, namely rejection, or ignoring/being hostile to a partner; coercion, or being controlling/demanding; and chaos, or unpredictability. Factor analysis supported the six-dimensional construct. The six PBSC dimensions, positive and negative subscales and total score had good distributional properties, high internal consistency, related as expected to other relationship quality measures, and diverged from most personality constructs. All PBSC scales were related to wellbeing, with some behaviours more related than others. For example, coercion was strongly associated with compromised wellbeing, while warmth showed weak, positive associations with positive functioning. The PBSC is expected to have utility in both research and clinical settings.
The Brief Attachment Adjective Checklist: A Measure of the Fourfold Definition of the Theory of Attachment
Authors: Bowles Terry 
Published: May 2012

AbstractThe aims of this research were to develop and validate a Brief Attachment Adjective Checklist (BAAC) to represent the four category model of attachment, compare it with a current measure of attachment, and use both to predict relationship satisfaction. A 32-item operationalisation of a hypothesised four-category model was analysed using a principal component analysis. Results of Study 1 (n = 174) indicated the items of the four-category model reflected good factor structure. Comparison with the four-paragraph Relationship Questionnaire (RQ) showed low correlation between the two operationalisations, suggesting that they were measuring different aspects of attachment. Analyses showed that the BAAC was a weak but better predictor of relationship satisfaction than the RQ. A confirmatory factor analysis in Study 2 (n = 131) refined the structure of the BAAC. The pattern of correlations showing relative independence of the BAAC and the RQ in Study 1 was also shown in Study 2. The frequency of respondents in dominant attachment categories of the RQ was consistent with previous research but the frequency of respondents in dominant attachment categories differed for RQ compared with the BAAC. The replication of the prediction of relationship satisfaction in Study 2 showed that both measures were weak predictors of relationship satisfaction but the BAAC was a better predictor than the RQ.
A focal subgroup theorem for outer commutator words
Authors: Acciarri Cristina , Fernández-Alcober Gustavo A. , Shumyatsky Pavel 
Published: May 2012

Abstract.
Let be a finite group of order , where is a prime and
is not divisible by , and let be a Sylow -subgroup of .
If is an outer commutator word, we prove that is
generated by the intersection of with the set of th powers
of all values of in .
Exploring the movement dynamics of manual and oral articulation: Evidence from coarticulation
Authors: Grosvald Michael , Corina David P. 
Published: May 2012

AbstractThis project explores three classes of human action through an investigation of long-distance coarticulation, defined here as the articulatory influence of one phonetic element (e.g., consonant or vowel) on another across more than one intervening element. Our first experiment investigated anticipatory vowel-to-vowel (VV) coarticulation in English. The second experiment was patterned after the first but deals instead with anticipatory location-to-location (LL) effects in American Sign Language (ASL). The sign experiment also incorporated a non-linguistic manual action, permitting a comparison of effects not only between spoken and signed language, but also between linguistic and non-linguistic manual actions.For the spoken-language study, sentences were created in which multiple consecutive schwas (target vowels) were followed by various context vowels. Eighteen English speakers were recorded as they repeated each sentence six times, and statistical tests were performed to determine the extent to which target vowel formant frequencies were influenced differently by different context vowels. For some speakers, significant effects of one vowel on another were found across as many as five intervening segments. In the sign study, motion-capture technology was used to investigate LL coarticulation in the signing of five ASL users. Some evidence was found of significant LL coarticulatory influence of one sign on another across as many as three intervening signs. However, LL effects overall were weaker and less pervasive than the VV effects found in the spoken-language study. The outcomes in the sign study's linguistic and non-linguistic conditions did not substantially differ. Collectively, these results support and complement previous research which has found that in comparisons of linguistic and non-linguistic manual and oral actions, movement patterns associated with oral and manual actions differ appreciably, while the linguistic vs. non-linguistic distinction appears to show little or no influence.
Matrix population models from 20 studies of perennial plant populations
Authors: Ellis Martha M. , Williams Jennifer L. , Lesica Peter , Bell Timothy J. , Bierzychudek Paulette , Bowles Marlin , Crone Elizabeth E. , Doak Daniel F. , Ehrlén Johan , Ellis-Adam Albertine , McEachern Kathryn , Ganesan Rengaian , Latham Penelope , Luijten Sheila , Kaye Thomas N. , Knight Tiffany M. , Menges Eric S. , Morris William F. , Nijs Hans den , Oostermeijer Gerard , Quintana-Ascencio Pedro F. , Shelly J. Stephen , Stanley Amanda , Thorpe Andrea , Ticktin Tamara , Valverde Teresa , Weekley Carl W. 
Published: May 2012

Demographic transition matrices are among the most commonly applied population models for both basic and applied ecological research. The relatively simple framework of these models and simple, easily interpretable summary statistics they produce have prompted the wide use of these models across an exceptionally broad range of taxa. Here, we provide annual transition matrices and observed stage structures/population sizes for 20 perennial plant species which have been the focal species for long‐term demographic monitoring. These data were assembled as part of the “Testing Matrix Models” working group through the National Center for Ecological Analysis and Synthesis (NCEAS). The data represent 82 populations with >460 total population‐years of observations. It is our hope that making these data available will help promote and improve our ability to monitor and understand plant population dynamics.The complete data sets corresponding to abstracts published in the Data Papers section of the journal are published electronically in Ecological Archives at 〈http://esapubs.org/archive〉. (The accession number for each Data Paper is given directly beneath the title.)
A Novel Approach for Enhanced Nanoparticle‐Sized Bone Substitute Adhesion to Chemically Treated Peri‐Implantitis–Affected Implant Surfaces: An In Vitro Proof‐of‐Principle Study
Authors: Gamal Ahmed Y. , Abdel‐Ghaffar Khaled A. , Iacono Vincent J. 
Published: May 2012

Background: The objective of this study is to evaluate micro and nano‐hydroxyapatite (NHA) blended clot adhesion to citric acid–conditioned peri‐implantitis–affected surfaces.Methods: Forty hopeless implants with peri‐implantitis designated for removal were included in this study. Implants were divided into eight groups of five each: group 1 (G1) test areas were coated with hydroxyapatite of a microparticle size (MHA); group 2 (G2) test areas were coated with NHA; group 3 (G3) implants were coated with MHA after surface conditioning using citric acid; group 4 (G4) samples were treated in the same manner as in G3 except for the use of NHA; group 5 (G5) samples were coated without surface treatment with MHA mixed with whole human blood; group 6 (G6) implant samples were treated in the same manner as in G5 except for the use of NHA; group 7 (G7) implant samples were treated in the same way as in G5 plus surface conditioning using citric acid; and group 8 (G8) samples were treated in the same manner as in G7 except for the use of NHA. All implants in all groups were agitated for 3 minutes in phosphate‐buffered saline. All samples were prepared for scanning electron microscopy evaluation.Results: G1 and G2 non‐etched implants coated with MHA or NHA sizes were devoid of any bone particle adhesion to the peri‐implantitis–affected surfaces. Contrary to the lack of microparticle adhesion to the root surface that was seen in G3, G4 acid‐treated and NHA‐coated samples revealed nearly complete coverage of the peri‐implantitis–affected parts by the graft material. G5 non‐etched, clot‐blended MHA showed some areas of clot‐blended graft adhesion covering 6.7% of the examined surfaces. G6 non‐etched, clot‐blended NHA showed NHA retention within the fibrin strands in areas where the implant surface pores were exposed (24.3%). G7 acid‐treated and clot‐blended MHA‐treated implant surfaces showed partial coverage of the implant surface with detached fibrin clot–blended graft material (31.4%). G8 acid‐treated and NHA clot‐blended graft‐coated implants showed complete coverage of the implant surface by the clot‐blended graft material (93.4%).Conclusion: Peri‐implantitis–affected surface conditioning with citric acid improves NHA‐blended clot adhesion to titanium implant surfaces.
Clinical Effects of Potassium–Titanyl–Phosphate Laser and Photodynamic Therapy on Outcomes of Treatment of Chronic Periodontitis: A Randomized Controlled Clinical Trial
Authors: Dilsiz Alparslan , Canakci Varol , Aydin Tugba 
Published: May 2012

Background: The main objective of periodontal treatment is to control infection and thereby curb disease progression. Recent studies have demonstrated that adjunctive treatment procedures, such as laser irradiation or photodynamic therapy (PDT), may provide some additional benefit in the treatment of chronic periodontitis (CP). The aim of this randomized controlled trial is to clinically evaluate and compare the clinical effects of potassium–titanyl–phosphate (KTP) laser and PDT on outcomes of CP treatment.Methods: Twenty‐four patients with untreated CP were treated using a split‐mouth study design in which the teeth in each quadrant were randomly treated by scaling and root planing (SRP) alone (group A), PDT followed by SRP (group B), or KTP laser followed by SRP (group C). The periodontal pockets were exposed to a KTP laser with the following parameters: 0.8 W output power, 50 milliseconds time on/50 milliseconds time off, 30 seconds per irradiation at 532 nm and 11.7 J/cm2 fluence, with a flexible fiberoptic tip with a diameter of 200 µm. The selected pockets were probed with a pressure‐controlled probe, guided by stents. Clinical periodontal parameters assessed included plaque index, gingival index, bleeding on probing (BOP), probing depth (PD), and clinical attachment level (CAL), which were recorded at baseline and at 6 months after therapy.Results: Statistical analysis demonstrated no differences between groups at baseline for all parameters (P >0.05). All treatments yielded significant improvements in terms of BOP and PD decrease and CAL gain compared to baseline values (P <0.05). Group C showed a greater reduction in PD compared to the other groups (P <0.05). In addition, group C showed a greater CAL gain compared to the other groups (P <0.05).Conclusion: In patients with CP, clinical outcomes from conventional periodontal treatment of deeper pockets can be improved by using adjunctive KTP laser.
Patterns of Attendance of Children Under 12 Years at School Dental Service in Western Australia
Authors: Lam SPL , Baros H , O’Grady MJ , Kendall GE , Messer LB , Slack-Smith LM 
Published: May 2012

The aim of this study was to investigate the patterns of attendance at School Dental Service (SDS) and reasons for attendance (treatment or prevention) for children in the Perth Metropolitan Area, in particular investigating the first year of SDS attendance and attendance until the year the child turned 12. The first 150 SDS records located for children from the Western Australian Pregnancy Cohort (Raine) Study were used for this study. Patterns of attendance of children at SDS were described, as were associated factors (enrolment, age and nature of first visit, general nature of visits and number of visits) until the end of the year that the child turned 12.The age of the child at the first SDS visit ranged from 4 years 3 months to 14 years 11 months, with a median of 5 years 1 month. First visits were primarily for an examination (98%). Children had a median of 13 visits until 12 years of age, with 10% having less than five visits and 4% having more than 25 visits.These data provide useful information regarding attendance at the SDS in Western Australia which could provide a basis for oral health promotion programs.