bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stable isotopic composition of Bothrops atrox (common lancehead) in four distinct land covers in eastern Amazonia
Authors: Martinez Melissa Gaste , de Camargo Plinio Barbosa , da Silva Ana Maria Moura , de Oliveira Junior Raimundo Cosme , de Menezes Chalkidis Hipócrates , dos Santos Junior Alfredo Pedroso , Mourão Rosa Helena Veras , Amazonas Diana Rêgo , Soltangheisi Amin , da Silva Araújo Maria Gabriella , Filho Adibe Luiz Abdalla , Martinelli Luiz Antonio 
Published: April 2024

AbstractSince consumers reflect the isotopic composition of an assimilated diet, stable isotopes can be a useful tool to address the feeding ecology of tropical snakes. This is the first study reporting carbon and nitrogen stable isotopic composition of Bothrops atrox (Linnaeus, 1758) living in different landscapes located in the lower Amazon river, encompassing four main natural landscapes of the Amazon: old‐growth forests, várzeas (flooded forests), savannas, and pastures. Our null hypothesis is that the δ13C of forest specimens of B.atrox is more negative because forests are dominated by C3 plants, while C4 plants are common in the other landscapes. On the other hand, δ15N of forest specimens should be more positive, since the δ15N of old‐growth forests are higher than plants of savanna, várzea, and pastures. Confirming our hypothesis, the δ13C of B. atrox scales of the Tapajós National Forest was approximate −25‰ to −24‰, increased to approximately −23.5‰ to −23.0‰ in the savanna and pasture, and to −21‰ in the várzea, showing an increased contribution of C4‐derived carbon. Some specimens of B. atrox had δ15N as high as 18‰, which is much higher than the average δ15N of the snake's prey (7‰), confirming the apex position of B. atrox in the Amazon region. The δ15N values of the forest specimens were 5‰ higher than the savanna specimens, and this difference decreased to 3‰ between the forest and the pasture, and the várzea specimens. Finally, there were not large differences between δ15N values of livers and scales in any of the landscapes, suggesting a constant diet through time, and reinforcing the possibility of the use of snake's scale as a less invasive and non‐lethal tissue to analyze.Abstract in Portuguese is available with online material.
Welfare effects of common ownership in an international duopoly
Authors: Liu Yi , Matsumura Toshihiro 
Published: April 2024

AbstractWe formulate an international oligopoly model in the presence of global common ownership. We theoretically investigate how common ownership affects the volume of international trade in an oligopoly market and global welfare. We find that welfare decreases (increases) with the degree of common ownership when the international transport costs are low (high), whereas common ownership reduces international trade. This conclusion remains valid in the presence of import tariffs and asymmetric common ownership share.
Brain areas interconnected to ventral pathway circuits are independently able to induce enhancement in object recognition memory and cause reversal in object recognition memory deficit
Authors: Masmudi‐Martín Mariam , Navarro‐Lobato Irene , López‐Aranda Manuel F. , Quiros‐Ortega María E. , Carretero‐Rey Marta , Garcia‐Garrido María F. , López Téllez Juan F. , Jiménez‐Recuerda Inmaculada , Muñoz de Leon López Cristina A. , Khan Zafar U. 
Published: April 2024

AbstractAimsVentral pathway circuits are constituted by the interconnected brain areas that are distributed throughout the brain. These brain circuits are primarily involved in processing of object related information in brain. However, their role in object recognition memory (ORM) enhancement remains unknown. Here, we have studied on the implication of these circuits in ORM enhancement and in reversal of ORM deficit in aging.MethodsThe brain areas interconnected to ventral pathway circuits in rat brain were activated by an expression of a protein called regulator of G‐protein signaling 14 of 414 amino acids (RGS14414). RGS14414 is an ORM enhancer and therefore used here as a gain‐in‐function tool. ORM test and immunohistochemistry, lesions, neuronal arborization, and knockdown studies were performed to uncover the novel function of ventral pathway circuits.ResultsAn activation of each of the brain areas interconnected to ventral pathway circuits individually induced enhancement in ORM; however, same treatment in brain areas not interconnected to ventral pathway circuits produced no effect. Further study in perirhinal cortex (PRh), area V2 of visual cortex and frontal cortex (FrC), which are brain areas that have been shown to be involved in ORM and are interconnected to ventral pathway circuits, revealed that ORM enhancement seen after the activation of any one of the three brain areas was unaffected by the lesions in other two brain areas either individually in each area or even concurrently in both areas. This ORM enhancement in all three brain areas was associated to increase in structural plasticity of pyramidal neurons where more than 2‐fold higher dendritic spines were observed. Additionally, we found that an activation of either PRh, area V2, or FrC not only was adequate but also was sufficient for the reversal of ORM deficit in aging rats, and the blockade of RGS14414 activity led to loss in increase in dendritic spine density and failure in reversal of ORM deficit.ConclusionsThese results suggest that brain areas interconnected to ventral pathway circuits facilitate ORM enhancement by an increase in synaptic connectivity between the local brain area circuits and the passing by ventral pathway circuits and an upregulation in activity of ventral pathway circuits. In addition, the finding of the reversal of ORM deficit through activation of an interconnected brain area might serve as a platform for developing not only therapy against memory deficits but also strategies for other brain diseases in which neuronal circuits are compromised.
Radiotherapy plus temozolomide with or without anlotinib in H3K27M‐mutant diffuse midline glioma: A retrospective cohort study
Authors: Liu Chao , Kuang Shuwen , Huang Tianxiang , Wu Jun , Zhang Longbo , Gong Xuan 
Published: April 2024

AbstractBackgroundBesides the hallmark of H3K27M mutation, aberrant amplifications of receptor tyrosine kinases (RTKs) are commonly observed in diffuse midline glioma (DMG), a highly malignant brain tumor with dismal prognosis. Here, we intended to evaluate the efficacy and safety of a multitarget RTK inhibitor anlotinib in patients with H3K27M‐DMG.MethodsA total of 40 newly diagnosed H3K27M‐DMG patients including 15 with anlotinib and 25 without anlotinib treatment were retrospectively enrolled in this cohort. Progression‐free survival (PFS), overall survival (OS), and toxicities were assessed and compared.ResultsThe median PFS and OS of all patients in this cohort were 8.5 months (95% CI, 6.5–11.3) and 15.5 months (95% CI, 12.6–17.1), respectively. According to the Response Assessment in Neuro‐Oncology (RANO) criteria, the disease control rate in the anlotinib group [93.3%, 95% confidence interval (CI), 70.2–98.8] was significantly higher than those without anlotinib (64%, 95% CI: 40.5–79.8, p = 0.039). The median PFS of patients with and without anlotinib was 11.6 months (95% CI, 7.8–14.3) and 6.4 months (95% CI, 4.3–10.3), respectively. Both the median PFS and OS of DMG patients treated with anlotinib were longer than those without anlotinib in the infratentorial patients (PFS: 10.3 vs. 5.4 months, p = 0.006; OS: 16.6 vs. 8.7 months, p = 0.016). Multivariate analysis also indicated anlotinib (HR: 0.243, 95% CI: 0.066–0.896, p = 0.034) was an independent prognosticator for longer OS in the infratentorial subgroup. In addition, the adverse events of anlotinib administration were tolerable in the whole cohort.ConclusionsThis study first reported that anlotinib combined with Stupp regimen is a safe and feasible regimen for newly diagnosed patients with H3K27M‐DMG. Further, anlotinib showed significant efficacy for H3K27M‐DMG located in the infratentorial region.
Long‐term risk of delayed postoperative Crohn's disease recurrence in patients with no or mild endoscopic recurrence at first assessment
Authors: Mañosa Míriam , Rivière Pauline , de Greef Ine , Oller Blanca , Roig Cristina , Calafat Margalida , Garcia‐Planella Esther , Laharie David , Ferrante Marc , Domènech Eugeni 
Published: April 2024

AbstractBackgroundEarly endoscopic evaluation is recommended for assessment of postoperative recurrence (POR) of Crohn's disease (CD) but no further monitoring recommendations are available.AimTo evaluate the long‐term outcome of patients without endoscopic POR at first endoscopic assessment.MethodsRetrospective four‐centre study including consecutive CD patients with ileocolonic resection (ICR) without endoscopic POR (Rutgeerts score i0‐i1) at first endoscopic assessment performed within 18 months from ICR. All patients had a clinical follow‐up ≥24 months and at least one further endoscopic assessment. Main outcomes were endoscopic, clinical and surgical POR, need for rescue therapy and “delayed POR” (any need for rescue therapy or clinical or surgical POR) during follow‐up.ResultsOverall, 183 patients were included (79% with risk factors for POR, 44% without postoperative prophylaxis). Endoscopic POR was observed in 42% of patients. Clinical POR‐free survival was 89.4% and 81.5% at 3 and 5 years, and delayed POR‐free survival was 76.9% and 63.4% at 5 and 10 years, respectively. In multivariate analysis, postoperative prophylaxis (HR .55; 95% CI .325–.942) and active smoking (HR 1.72; 95%CI 1.003–2.962) were independent risk factors for clinical POR, whereas presence of mild endoscopic lesions at index ileocolonoscopy (i1) was the only risk factor for delayed POR (HR 1.824; 95% CI 1.108–3.002).ConclusionsLong‐term risk of POR among patients with no or mild endoscopic lesions at first ileocolonoscopy after surgery is steadily low, being higher among smokers, in the absence of postoperative prophylaxis and when mild endoscopic lesions are observed in the first endoscopic assessment.
Termite females prefer hybrid mating to parthenogenesis when conspecific males are absent
Authors: Wu Jia , Wang Jinpei , Yue Zhiyong , Jiang Qi , Guo Rui , Jia Bao 
Published: April 2024

Abstract
Parthenogenesis and interspecific mating are alternative reproductive strategies that species have evolved alternative strategies when the opportunity of sexual reproduction is hindered by the natural environment. However, it is still unclear how to make a choice between parthenogenesis and interspecific mating when females are unable to reproduce sexually with males of the same species.
This study mainly investigated the reproductive behaviour of female termites in the absence of male termites of the same species. Here, reproductive behaviours of females Reticulitermes aculabialis (Ra♀) were observed when they encountered a male R. flaviceps (Rf♂) with the absence of male R. aculabialis(Ra♂).
The results showed that Ra♀‐Rf♂ tandems were more prevalent and stable compared to Ra♀‐Ra♀ tandems. When a tandem inadvertently broke apart, the female R. aculabialis displayed longer pauses while waiting for male R. flaviceps, but shorter pauses when another female R. aculabialis was involved. Furthermore, there were mating behaviour between female R. aculabialis and males R. flaviceps, resulting in offspring produced in paired Ra♀‐Rf♂ colonies were hybridization between female R. aculabialis and male R. flaviceps.
These results suggest that interspecific mating and recombination is an important aspect for the choice of reproduction strategy, which will provide new insights into the trade‐off between gene contribution rate and genetic diversity.
Developmental plasticity of melanisation in a beetle reveals sex‐specific responses and performance costs
Authors: Kutama Dianah M. , Minnaar Ingrid A. , Starostová Zuzana , Clusella‐Trullas Susana 
Published: April 2024

Abstract
Dark pigmentation of adults resulting from cold exposure during development is ubiquitous among insects. Yet the costs associated with the developmental plasticity of melanisation have been explored only for a handful of species.
We explored two hypotheses relating to colour plasticity of insects. First, if melanin pigments are costly to synthesise and require allocation of resources, increased melanisation should be negatively associated with performance traits (the cost hypothesis). Second, given the positive association between melanisation and immune responses or desiccation resistance in some species, melanisation and performance may co‐vary positively (the positive covariance hypothesis). Furthermore, given the typical differences in reproductive effort and activity between females and males, we expect these performance–melanisation relationships to differ between sexes.
We assessed whether temperature‐induced melanisation of the globally invasive beetle Harmonia axyridis f. succinea (Pallas) (Coleoptera: Coccinellidae) was related to standard metabolic rate and flight performance while accounting for developmental temperature and family affiliation.
Melanisation explained little variation in standard metabolic rate at most temperatures tested (15, 20, 25, 30 and 35°C). For flight performance and after the cold‐rearing regime, lighter coloured female beetles had increased flight speed compared with darker females, whereas the opposite was found in males. In addition, in warm‐reared beetles, darker individuals had lower mean flight speeds.
The results suggest that at least some flight performance costs are associated with developmentally induced melanisation, supporting the cost hypothesis. Disparities in these relationships between males and females suggest that the drivers underlying variation in melanisation differ between sexes. Importantly, variation in melanisation was more acute for females reared in the warm regime compared with equally treated males and to cold‐reared individuals. We propose new directions to test hypotheses pertaining to the maintenance of colour variation and performance between sexes in nature.
Field effects and work‐based learning: The case of school–work alternance in Italy
Authors: Pinna Gabriele , Pitzalis Marco 
Published: April 2024

AbstractThis essay analyses the implementation of a work‐based learning policy in upper secondary schools in Italy. The policy aims to improve student orientation and enhance their soft skills. Based on two ethnographic research studies in Italy, this essay utilises Pierre Bourdieu's theoretical framework, particularly the ‘field’ concept, to examine how this policy has been implemented in different tracks of the Italian school system in a peripheral region. The policy has challenged the autonomy of the scholastic field, primarily advocated by teachers and students in the dominant pole, represented by the classical and scientific lyceums. The policy has been translated into a series of projects in museums, libraries and third‐sector associations in this field segment. These initiatives reinforce students' citizenship values while highlighting their detachment from manual work. In the dominated pole of the field, represented by vocational schools primarily located in the suburbs of large cities and rural areas, the policy has been well received as it aligns with the expectations of teachers and students. However, due to the prevalence of small family companies, planning truly formative work‐based learning experiences becomes challenging. Consequently, this leads to an early, albeit tense, socialisation of students within the hierarchical order of small companies.
Coma in adult cerebral venous thrombosis: The BEAST study
Authors: Ranjan Redoy , Ken‐Dror Gie , Martinelli Ida , Grandone Elvira , Hiltunen Sini , Lindgren Erik , Margaglione Maurizio , Duchez Veronique Le Cam , Triquenot Bagan Aude , Zedde Marialuisa , Giannini Nicola , Ruigrok Ynte M. , Worrall Bradford B. , Majersik Jennifer J. , Putaala Jukka , Haapaniemi Elena , Zuurbier Susanna M. , Brouwer Matthijs C. , Passamonti Serena M. , Abbattista Maria , Bucciarelli Paolo , Lemmens Robin , Pappalardo Emanuela , Costa Paolo , Colombi Marina , Aguiar de Sousa Diana , Rodrigues Sofia , Canhão Patrícia , Tkach Aleksander , Santacroce Rosa , Favuzzi Giovanni , Arauz Antonio , Colaizzo Donatella , Spengos Kostas , Hodge Amanda , Ditta Reina , Pezzini Alessandro , Coutinho Jonathan M. , Thijs Vincent , Jood Katarina , Tatlisumak Turgut , Ferro José M. , Sharma Pankaj 
Published: April 2024

AbstractBackground and purposeComa is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT.MethodsWe used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with <10% missing data in univariate analysis were considered for the multivariate logistic regression model.ResultsOf the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female‐predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p < 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5–60) versus 40 (33–47) years in the coma (p = 0.04) and 44.5 (34–58) versus 37 (29–48) years in the non‐coma sample (p < 0.001), respectively. Furthermore, an age‐ and superior sagittal sinus‐adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0–3.4, p = 0.04) to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52–0.68, p = 0.01).ConclusionsAlthough CVT is a female‐predominant disease, men were older and nearly twice as likely to suffer from coma than women.
Variation in genomic vulnerability to climate change across temperate populations of eelgrass (Zostera marina)
Authors: Jeffery Nicholas W. , Vercaemer Benedikte , Stanley Ryan R. E. , Kess Tony , Dufresne France , Noisette Fanny , O'Connor Mary I. , Wong Melisa C. 
Published: April 2024

AbstractA global decline in seagrass populations has led to renewed calls for their conservation as important providers of biogenic and foraging habitat, shoreline stabilization and carbon storage. Eelgrass (Zostera marina) occupies the largest geographic range among seagrass species spanning a commensurately broad spectrum of environmental conditions. In Canada, eelgrass is managed as a single phylogroup despite occurring across three oceans and a range of ocean temperatures and salinity gradients. Previous research has focused on applying relatively few markers to reveal population structure of eelgrass, whereas a whole‐genome approach is warranted to investigate cryptic structure among populations inhabiting different ocean basins and localized environmental conditions. We used a pooled whole‐genome re‐sequencing approach to characterize population structure, gene flow and environmental associations of 23 eelgrass populations ranging from the Northeast United States to Atlantic, subarctic and Pacific Canada. We identified over 500,000 SNPs, which when mapped to a chromosome‐level genome assembly revealed six broad clades of eelgrass across the study area, with pairwise FST ranging from 0 among neighbouring populations to 0.54 between Pacific and Atlantic coasts. Genetic diversity was highest in the Pacific and lowest in the subarctic, consistent with colonization of the Arctic and Atlantic oceans from the Pacific less than 300 kya. Using redundancy analyses and two climate change projection scenarios, we found that subarctic populations are predicted to be potentially more vulnerable to climate change through genomic offset predictions. Conservation planning in Canada should thus ensure that representative populations from each identified clade are included within a national network so that latent genetic diversity is protected, and gene flow is maintained. Northern populations, in particular, may require additional mitigation measures given their potential susceptibility to a rapidly changing climate.
New directions for Indigenous and local knowledge research and application in fisheries science: Lessons from a systematic review
Authors: Jones Benjamin L. H. , Santos Rolando O. , James W. Ryan , Costa Sophia V. , Adams Aaron J. , Boucek Ross E. , Coals Lucy , Cullen‐Unsworth Leanne C. , Shephard Samuel , Rehage Jennifer S. 
Published: April 2024

AbstractSocial‐ecological systems like fisheries provide food, livelihoods and recreation. However, lack of data and its integration into governance hinders their conservation and management. Stakeholders possess site‐specific knowledge crucial for confronting these challenges. There is increasing recognition that Indigenous and local knowledge (ILK) is valuable, but structural differences between ILK and quantitative archetypes have stalled the assimilation of ILK into fisheries management, despite acknowledged bias and uncertainty in scientific methods. Conducting a systematic review of fisheries‐associated ILK research (n = 397 articles), we examined how ILK is accessed, applied, distributed across space and species, and has evolved. We show that ILK has generated qualitative, semi‐quantitative and quantitative information for diverse taxa across 98 countries. Fisheries‐associated ILK research mostly targets small‐scale and artisanal fishers (70% of studies) and typically uses semi‐structured interviews (60%). We revealed large variability in sample size (n = 4–7638), predicted by the approach employed and the data generated (i.e. qualitative studies target smaller groups). Using thematic categorisation, we show that scientists are still exploring techniques, or ‘validating’ ILK through comparisons with quantitative scientific data (20%), and recording qualitative information of what fishers understand (40%). A few researchers are applying quantitative social science methods to derive trends in abundance, catch and effort. Such approaches facilitate recognition of local insight in fisheries management but fall short of accepting ILK as a valid complementary way of knowing about fisheries systems. This synthesis reveals that development and increased opportunities are needed to bridge ILK and quantitative scientific data.
Queerness, Affekte und Eigensinn in Grimmelshausens Courasche (1670)
Authors: Daldrup Alrik 
Published: April 2024

AbstractAusgehend von der Überlegung, dass Grimmelshausens Courasche (1670) trotz einer konservativen Botschaft ein epistemisch subversives Sujet bietet, analysiert der Beitrag den Roman mithilfe von Sara Ahmeds queerer Affekttheorie. Grimmelshausens Protagonistin geht einen bösen Weg, der sie weit von den vorgeschriebenen Pfaden der christlichen Weltordnung abbringt, ihr jedoch auch eine kreative Politik der Verweigerung ermöglicht, etwas anderes sehen, spüren und erschaffen zu können. Courasche kann ihre hässlichen Gefühle nicht beherrschen, was dazu führt, dass sie die Räume, Objekte und Sprechweisen der Weltordnung auf eine queere Weise nutzt. Ebenso queer ist die Slapstick‐Ästhetik des Romans, die in Momenten affektiver Entgleisung zum Tragen kommt. Courasche zensiert sich nicht selbst, um der Dominanzgesellschaft anzugehören, worauf diese mit disziplinierender Gewalt reagiert, damit Anständigkeit wiederhergestellt ist. Doch Courasche leistet Widerstand gegen die voyeuristischen Blicke der anderen. Sie bewahrt sich Eigensinn, indem sie Bedeutungen produziert, deren Zeit noch nicht gekommen ist und die die Christenmenschen nicht verstehen.