bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of antireaction medications on the association between periodontitis and leprosy reactions: An important methodological issue in periodontal medicine
Authors: Sacramento Isabela de Souza , Gomes‐Filho Isaac Suzart , Cruz Simone Seixas da , Trindade Soraya Castro , Figueiredo Ana Claudia Morais Godoy , Machado Paulo Roberto Lima , Vianna Maria Isabel Pereira , Falcão Michelle Miranda Lopes , Hintz Alexandre Marcelo , de Lacerda Juliana Andrade , Matos Bruno Costa , Seymour Gregory John , Scannapieco Frank Andrew , Loomer Peter Michael , Passos‐Soares Johelle de Santana 
Published: June 2024

AbstractBackground: The treatment of leprosy reactions (LRs) involves thalidomide, corticosteroids, and other immunomodulatory medications. This study evaluated the effect of these treatments on the association between periodontitis and LRs, as well as factors associated with LRs.Methods: This case–control study was conducted on 283 individuals followed at a leprosy outpatient clinic in Brazil. The case group was comprised of 158 individuals presenting type 1 or type 2 LRs, and the control group of 125 leprosy individuals without reactions. A complete oral examination was performed to diagnose periodontitis, the independent variable. Antireaction medication used was collected from medical records, and participants were classified according to the use of prednisone and/or thalidomide, time of use, or non‐use of medication. Socioeconomic–demographic, clinical, and lifestyle covariables were collected by interview. Unconditional logistic regression analysis by subgroups evaluated the effect of antireaction medication on the association between periodontitis and LRs, estimating the odds ratio with a 95% confidence interval (OR; 95% CI).Results: A relationship between periodontitis and LRs was observed only in the subgroup using the association prednisone and thalidomide: ORadjusted = 0.32; 95% CI = 0.11–0.95. Conversely, more severe periodontal clinical parameters were observed in cases versus controls. Several socioeconomic, health conditions, and lifestyle factors were associated with the presence of LRs.Conclusions: Although periodontal disease indicators were worse among the cases, the findings showed a negative relationship between periodontitis and LRs in individuals receiving associated prednisone and thalidomide. These medications appear to influence the inflammatory cascade between diseases, modifying and masking the manifestations of periodontitis.
Infant versus noninfant formulas and cow's milk: Transition based on age or weight?
Authors: Orkin Sarah , Hitchcock Kathryn , Phillips Jennifer , Romantic Emily , Trauth Amiee , Wessel Jacqueline , Mouzaki Marialena 
Published: June 2024

AbstractInfant formulas are meant to be used until 1 year of age, at which point children are transitioned to non‐infant formulas or cow's milk, depending on their remaining dietary intake. Noninfant formulas and cow's milk are appropriate for children who have an average weight at that 1‐year mark (9–9.5 kg); however, can contribute significant protein and/or electrolytes to children who are underweight for age, particularly if they still rely heavily on formula feeding for their caloric intake. In this short communication, we present several cases of patients who received excessive amounts of nutrients for age following the formula transition at the 1‐year mark. We also provide recommendations for clinicians to consider when faced with underweight infants who are meant to be transitioning off infant formulas.
Micro‐Raman study of black and red decorations of Neolithic Yangshao potteries excavated from Taiyuan city, Shanxi province, China (c. 3000 BCE)
Authors: Wang Ying , Yang Yuanqing , Hou Liangliang , Guo Rui , Wang Fen , Zhu Jianfeng , Pei Jingrong , Luo Hongjie , Wang Tian 
Published: June 2024

AbstractYangshao culture, as the most important Neolithic culture in China, is famous for its finely decorated pottery. In this work, Yangshao potteries excavated in Shanxi province, one of the core distribution areas, were studied by micro‐Raman spectroscopy combined with optical microscopy, X‐ray fluorescence, and scanning electron microscopy equipped with energy‐dispersive X‐ray spectroscopy. The color of the red decor is derived from hematite and maghemite. The black decorations on the surface are more complex, which could be divided into two types according to the Mn/Fe ratios and crystalline types: (1) low MnO2/Fe2O3 ratio and jacobsite and magnetite and (2) high MnO2/Fe2O3 ratio and hausmannite. The former color is obviously brighter than the latter. This study also demonstrates the potential of micro‐Raman microscopy in analyzing the nature of colorant crystals in Yangshao painted potteries and, therefore, better deciphering the technical details involved in the potteries of Yangshao culture.
Effects of foliar application of methyl jasmonate and/or urea, conventional or via nanoparticles, on grape volatile composition
Authors: Torres‐Díaz Lesly L. , Pérez‐Álvarez Eva P , Parra‐Torrejón Belén , Marín‐San Román Sandra , de Sáenz de Urturi Itziar , Ramírez‐Rodríguez Gloria B , Murillo‐Peña Rebeca , González‐Lázaro Miriam , Delgado‐López José M , Garde‐Cerdán Teresa 
Published: June 2024

AbstractBACKGROUNDViticulture has adapted foliar applications of biostimulants as a tool to improve crop quality. Recently, nanotechnology has been incorporated as a strategy to reduce the loss of biostimulants and treat nutrient deficiencies. Therefore, the present study aimed to investigate the effect of foliar applications of amorphous calcium phosphate nanoparticles (ACP) doped with methyl jasmonate (ACP‐MeJA) and urea (ACP‐Ur), individually or together (ACP‐MeJA+Ur), on the content of volatile compounds in ‘Tempranillo’ grapes, compared to the conventional application of MeJA and Ur, individually or in combination (MeJA+Ur).RESULTSThe results showed that nanoparticle treatments reduced the total C6 compounds and some carbonyl compounds in the grape musts. This is of novel interest because their presence at high levels is undesirable to quality. In addition, some aroma‐positive compounds such as nerol, neral, geranyl acetone, β‐cyclocitral, β‐ionone, 2‐phenylethanal and 2‐phenylethanol increased, despite applying MeJA and Ur at a lower dose.CONCLUSIONConsequently, although few differences in grape volatile composition were detected, nanotechnology could be an option for improving the aromatic quality of grapes, at the same time as reducing the required doses of biostimulants and generating more sustainable agricultural practices. © 2024 The Author(s). Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Effects of foliar spraying different sizes of zinc fertilizer on the growth and cadmium accumulation in rice
Authors: Ma Haorui , You Laiyong , Yi Xiu , Ding Chengcheng , Zhou Jing , Zhou Jun 
Published: June 2024

AbstractBACKGROUNDNanotechnology has been widely applied in agricultural science. During the process of reducing metal toxicity and accumulation in rice, nanomaterials exhibit size effects. However, there is limited knowledge regarding these size effects. We aim to explore the impact of fertilizer with various sizes of ZnO nanoparticles (ZnO‐NPs) on rice growth and cadmium (Cd) accumulation and to elucidate the potential mechanism of Cd reduction in rice. Foliar applications of different concentrations (0.5 and 2 mmol L−1) and different sizes (30 and 300 nm ZnO‐NPs) of zinc (Zn) fertilizer (Zn(NO3)2) were performed to investigate the effects on rice growth, Cd accumulation and subcellular distribution, and the expression of Zn–Cd transport genes.RESULTSThe results suggested that all the foliar sprayings can significantly reduce the Cd concentrations in rice grains by 41–61% with the highest reduction in the application of ZnO‐NPs with large size and low concentration. This is related to the enhancement of Cd fixation in leaf cell walls and downregulation of Cd transport genes (OsZIP7, OsHMA2, OsHMA3) in stem nodes. Foliar ZnO‐NPs applications can increase the Zn concentration in grains by 9–21%. Foliar applications of Zn(NO3)2 and small‐sized ZnO‐NPs promoted plant growth and rice yield, while the application of large‐sized ZnO‐NPs significantly reduced rice growth and yield.CONCLUSIONThe study suggests that the rice yield and Cd reduction are dependent on the size and concentration of foliar spraying and the use of large‐sized ZnO‐NPs is the most effective strategy when considering both yield and Cd reduction comprehensively. © 2024 Society of Chemical Industry.
Kappa‐carrageenan and xylooligosaccharide effect on water mobility and structural changes in silver carp proteins during frozen storage
Authors: Walayat Noman , Wei Ran , Lorenzo Jose M , Nawaz Asad , Khalifa Ibrahim , Su Zhucheng , Salah Mahmoud , Ahmed Mukhtar 
Published: June 2024

AbstractBACKGROUNDThe cryoprotective effect of xylooligosaccharide (XO) and kappa‐carrageenan (KC) mixture on silver carp proteins in fluctuated frozen storage from 4 to −18 °C was analyzed. Positive control as a conventional cryoprotectant mixture of sucrose (4%) and sorbitol (4%), KC (3%) and XO/KC (3%) treatments were incorporated in silver carp surimi and myofibrillar proteins to analyze the water mobility and its influence on structural attributes.RESULTSThe temperature fluctuation significantly increased the structural alteration in samples with no treatments due to oxidative changes, protein denaturation and recrystallization. Meanwhile, the mixture of XO and KC (XO/KC 3%) significantly reduced the tertiary and secondary structural alterations by preventing the oxidative changes in α‐helix and tryptophan (Trp) residues. Moreover, XO/KC (3%) inhibited water mobility, hindering the T22 relaxation time, as compared to the samples added with KC (3%) and the positive control. Interestingly, the XO/KC (3%) mixture significantly reduced the formation of extracellular spaces and recrystallization by restricting the partial dehydration of muscles and extracellular solution concentration.CONCLUSIONFrom the current results, it can be concluded that the XO/KC mixture could be efficient in protecting aquatic food proteins during fluctuating frozen storage by preventing the exposure of Trp residues and α‐helix contents. Moreover, XO/KC restricted the water mobility by establishing a bond and making water unavailable for crystallization and recrystallization. Therefore, XO/KC could be used as an effective mixture to prevent fluctuated and frozen storage changes in aquatic foods. © 2024 Society of Chemical Industry.
Vertical field‐effect transistor using c‐axis aligned crystal indium–gallium–zinc oxide on glass substrate and prototype organic light‐emitting diode display
Authors: Nakada Masataka , Shima Yukinori , Jincho Masami , Sato Manabu , Kurosaki Daisuke , Koezuka Junichi , Okazaki Kenichi , Saito Motoharu , Kusunoki Koji , Atsumi Tomoaki , Seo Norihiko , Yamazaki Shunpei 
Published: June 2024

AbstractThis study developed a technology for a vertical field‐effect transistor (VFET) incorporating c‐axis aligned crystal oxide semiconductor on a Gen 3.5 glass substrate. VFETs, with a channel length of 0.5 μm, demonstrated stable characteristics with minimal variation, higher on‐state current compared with low‐temperature polysilicon FETs, and extremely low off‐state leakage current. A prototype 513‐ppi organic light‐emitting diode display that features a red, green, and blue stripe arrangement and includes an internal compensation circuit with a configuration of six transistors and two capacitors was fabricated by harnessing the advantageous features of VFETs. Such a display was previously unattainable with planar FETs. Thus, the developed VFET technology presents a viable pathway for achieving ultrahigh‐resolution panels on glass substrates.
A review of portal vein embolization prior to hepatic resection
Authors: Sivakumar Ishwarya , Liddell Robert P. 
Published: June 2024

AbstractPrimary and metastatic liver cancers are increasing in incidence, and the approaches with the longest survival are resection and transplantation. Posthepatectomy liver failure (PHLF) is the leading cause of mortality following liver resection. PHLF is largely due to liver insufficiency due to the insufficient size of the future liver remnant (FLR). In this review, we will describe portal vein embolization, which is a neoadjuvant therapy used to induce hypertrophy in the FLR before resection.
Who still needs surgical staging of the axilla for invasive breast cancer?
Authors: Kelley Kathryn , Sener Stephen F. 
Published: June 2024

AbstractSentinel lymphadenectomy may be safely omitted for postmenopausal patients with low‐risk estrogen‐receptor‐positive cancers who have a negative pretreatment axillary ultrasound. Surgical staging should still be done for patients who are premenopausal or postmenopausal with high‐risk estrogen receptor‐positive cancers, for those having neoadjuvant chemotherapy, or those with estrogen‐receptor‐negative or human epidermal growth factor receptor‐positive cancers.
circUQCRC2 promotes asthma progression in children by activating the VEGFA/NF‐κB pathway by targeting miR‐381‐3p
Authors: Yang Li‐Juan , Sui Shu‐Xiang , Zheng Qing‐Hua , Wang Min 
Published: June 2024

AbstractThis study targeted to explore circUQCRC2's role and mechanism in childhood asthma. A mouse model of ovalbumin‐induced asthma was established to evaluate the effects of circUQCRC2 on childhood asthma in terms of oxidative stress, inflammation, and collagen deposition. The effects of circUQCRC2 on platelet‐derived growth factor‐BB (PDGF‐BB)‐induced smooth muscle cells (SMCs) were evaluated, the downstream mRNA of miRNA and its associated pathways were predicted and validated, and their effects on asthmatic mice were evaluated. circUQCRC2 levels were upregulated in bronchoalveolar lavage fluid of asthmatic mice and PDGF‐BB‐treated SMCs. Depleting circUQCRC2 alleviated tissue damage in asthmatic mice, improved inflammatory levels and oxidative stress in asthmatic mice and PDGF‐BB‐treated SMC, inhibited malignant proliferation and migration of SMCs, and improved airway remodeling. Mechanistically, circUQCRC2 regulated VEGFA expression through miR‐381‐3p and activated the NF‐κB cascade. circUQCRC2 knockdown inactivated the NF‐κB cascade by modulating the miR‐381‐3p/VEGFA axis. Promoting circUQCRC2 stimulates asthma development by activating the miR‐381‐3p/VEGFA/NF‐κB cascade. Therefore, knocking down circUQCRC2 or overexpressing miR‐381‐3p offers a new approach to treating childhood asthma.
Intraoperative lateral laxity greater than 4° is associated with inferior functional improvement in posterior‐stabilised total knee arthroplasty
Authors: Inokuchi Takao , Muratsu Hirotsugu , Kamenaga Tomoyuki , Tsubosaka Masanori , Nakano Naoki , Hayashi Shinya , Kuroda Ryosuke , Matsumoto Tomoyuki 
Published: June 2024

AbstractPurposeThe study aimed to determine the impact of intraoperative lateral laxity at extension on clinical and functional outcomes 1 year after posterior‐stabilised total knee arthroplasty (PS‐TKA).MethodsIn total, 91 varus‐type osteoarthritic knees that underwent PS‐TKA using the medial preservation gap technique were included. After the femoral trial component placement and patellofemoral joint reduction, the soft‐tissue balance was assessed using an offset‐type tensor with a 40‐lb joint‐distraction force. Patients were divided into the following three groups according to the intraoperative lateral laxity at extension (i.e., varus ligament balance) using the mean ± 1 standard deviation: Groups A, ≤0°; B, 0–4°; and C, >4°. The 2011 Knee Society Score (KSS) and 3‐m timed up‐and‐go test (TUG) time 1‐year postoperatively, and their improvements were compared among the groups.ResultsWhile significant improvements were observed in all subscales of the 2011 KSS and TUG post‐TKA (p < 0.05), the improvement of functional activities and TUG time were significantly lower in Group C than in Group B (p < 0.05). However, no significant differences were observed in symptom improvement, patient satisfaction or patient expectation scores among the groups.ConclusionAn excessive lateral laxity (varus angle) >4° at extension was associated with lower improvement in functional ability 1‐year postoperatively. Therefore, excessive intraoperative lateral laxity should be avoided in PS‐TKA.Level of EvidenceLevel IV.
Overnight Monitoring Criteria for Children with Obstructive Sleep‐Disordered Breathing After Tonsillectomy: Revisited
Authors: Jáuregui Emmanuel J. , Diala Obinna , Rove Kyle O. , Hoefner‐Notz Regina , Tong Suhong , Nguyen Thanh , Friedman Norman R. 
Published: June 2024

ObjectivesPrevious studies indicate children who pass an Asleep Room Air Challenge (AsRAC) do not have significant postoperative adverse respiratory events after adenotonsillectomy (T&A).Subsequently, we revised our overnight monitoring (OM) criteria, allowing patients with an obstructive apnea/hypopnea index (OAHI) ≤20 or nonsevere obesity (Class I) to be considered for same‐day surgery (SDS) if they passed an AsRAC.Our hypothesis is that our modified OM criteria would not increase the return visits or readmission rates for patients undergoing SDS within 48 h or 15 days of T&A.MethodsA retrospective review of all children aged ≥3 and <21 years who underwent T&A at a tertiary children's hospital and its satellite locations was performed from January 2017 to September 2022. Descriptive statistics and outcome measures were compared using a 3% margin noninferiority test before and after the new criteria implementation.ResultsBefore intervention, 3,266 (58%) T&As were performed as SDS.Afterward, 74% of T&As were performed as SDS (p‐value <0.05). There was no difference in the ED revisit rate for SDS within the 3% noninferiority margin. Following intervention, 29% more children with Class I obesity (62% vs. 33%) underwent SDS (p‐value <0.001). Afterward, 19% more children with polysomnography underwent SDS (39% vs. 20%), p‐value <0.001. After intervention, within 48 h of SDS, six (0.9%) children had revisits for bleeding and seven (1.2%) for vomiting. There were no perioperative respiratory events.ConclusionOur revised monitoring criteria did not demonstrate an increase in ED visit or readmissions rates within 48 h or 15 days of T&A. Additionally, we found a 29% increase in Class I obese children undergoing SDS T&A.Level of Evidence3 Laryngoscope, 134:5223–5230, 2024
Accumulated soil seed bank of the invasive sand dropseed (Sporobolus cryptandrus) poses a challenge for its suppression
Authors: Török Péter , Espinoza Ami Francis David , Szél‐Tóth Katalin , Díaz Cando Patrícia , Guallichico Suntaxi Luis Roberto , McIntosh‐Buday Andrea , Hábenczyus Alida Anna , Törő‐Szijgyártó Viktória , Kovacsics‐Vári Gergely , Tölgyesi Csaba , Tóthmérész Béla , Sonkoly Judit 
Published: June 2024

AbstractGlobal warming, elevated atmospheric CO2 concentrations and increased likeliness of extreme drought and wildfires in many regions will likely favour C4 grass species. To support future management actions, we explored the effect of the encroachment of an invasive perennial C4 grass, Sporobolus cryptandrus on the composition of soil seed banks in dry sand grasslands in Central Europe. In five mass‐locality sites of the species we assessed the composition and vertical segmentation of the soil seed bank in 12 1‐m2 plots along an increasing cover of the invasive species. We found that the seed bank diversity and density decreased with increasing sampling depth; the decrease in density was affected by the increasing S. cryptandrus cover. Neither the diversity nor the seed bank density of other species were affected by increasing S. cryptandrus cover but both were affected by the sampling site. Most of the studied seed bank characteristics were affected by the sampling depth, but none of them were affected by the increasing cover of S. cryptandrus. Increasing cover of S. cryptandrus in the vegetation was associated with an increasing proportion of S. cryptandrus seeds in the seed bank, and we found a low‐density soil seed bank of the species even in plots with no S. cryptandrus cover. Our finding that S. cryptandrus forms a massive soil seed bank, together with the predicted decrease in the precipitation of the summer months and increase in the frequency of droughts in the region, projects further rapid spread of the species.
Exploring drug repositioning possibilities of kinase inhibitors via molecular simulation**
Authors: Wang Qing‐Xin , Cai Jiao , Chen Zi‐Jun , Liu Jia‐Chuan , Wang Jing‐Jing , Zhou Hai , Li Qing‐Qing , Wang Zi‐Xuan , Wang Yi‐Bo , Tong Zhen‐Jiang , Yang Jin , Wei Tian‐Hua , Zhang Meng‐Yuan , Zhou Yun , Dai Wei‐Chen , Ding Ning , Leng Xue‐Jiao , Yin Xiao‐Ying , Sun Shan‐Liang , Yu Yan‐Cheng , Li Nian‐Guang , Shi Zhi‐Hao 
Published: June 2024

AbstractKinases, a class of enzymes controlling various substrates phosphorylation, are pivotal in both physiological and pathological processes. Although their conserved ATP binding pockets pose challenges for achieving selectivity, this feature offers opportunities for drug repositioning of kinase inhibitors (KIs). This study presents a cost‐effective in silico prediction of KIs drug repositioning via analyzing cross‐docking results. We established the KIs database (278 unique KIs, 1834 bioactivity data points) and kinases database (357 kinase structures categorized by the DFG motif) for carrying out cross‐docking. Comparative analysis of the docking scores and reported experimental bioactivity revealed that the Atypical, TK, and TKL superfamilies are suitable for drug repositioning. Among these kinase superfamilies, Olverematinib, Lapatinib, and Abemaciclib displayed enzymatic activity in our focused AKT‐PI3K‐mTOR pathway with IC50 values of 3.3, 3.2 and 5.8 μM. Further cell assays showed IC50 values of 0.2, 1.2 and 0.6 μM in tumor cells. The consistent result between prediction and validation demonstrated that repositioning KIs via in silico method is feasible.
Updating and profiling the natural product‐likeness of Latin American compound libraries**
Authors: Gómez‐García Alejandro , Prinz Ann‐Kathrin , Jiménez Daniel A. Acuña , Zamora William J. , Barazorda‐Ccahuana Haruna L. , Chávez‐Fumagalli Miguel Á. , Valli Marilia , Andricopulo Adriano D. , da S. Bolzani Vanderlan , Olmedo Dionisio A. , Solís Pablo N. , Núñez Marvin J. , Rodríguez Pérez Johny R. , Sánchez Hoover A. Valencia , Cortés Hernández Héctor F. , Mosquera Martinez Oscar M. , Koch Oliver , Medina‐Franco José L. 
Published: June 2024

AbstractCompound databases of natural products play a crucial role in drug discovery and development projects and have implications in other areas, such as food chemical research, ecology and metabolomics. Recently, we put together the first version of the Latin American Natural Product database (LANaPDB) as a collective effort of researchers from six countries to ensemble a public and representative library of natural products in a geographical region with a large biodiversity. The present work aims to conduct a comparative and extensive profiling of the natural product‐likeness of an updated version of LANaPDB and the individual ten compound databases that form part of LANaPDB. The natural product‐likeness profile of the Latin American compound databases is contrasted with the profile of other major natural product databases in the public domain and a set of small‐molecule drugs approved for clinical use. As part of the extensive characterization, we employed several chemoinformatics metrics of natural product likeness. The results of this study will capture the attention of the global community engaged in natural product databases, not only in Latin America but across the world.