bluuebunny/crossref_metadata_2025_split huggingface dataset:
CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche
Authors: Kim Minah , Koh Young Jun , Kim Kyung Eun , Koh Bong Ihn , Nam Do-Hyun , Alitalo Kari , Kim Injune , Koh Gou Young 
Published: November 2010

Abstract
Highly metastatic and chemotherapy-resistant properties of malignant melanomas stand as challenging barriers to successful treatment; yet, the mechanisms responsible for their aggressive characteristics are not fully defined. We show that a distinct population expressing CD133 (Prominin-1), which is highly enriched after administration of a chemotherapeutic drug, dacarbazine, has enhanced metastatic potential in vivo. CD133+ tumor cells are located close to tumor-associated lymphatic vessels in metastatic organs such as the regional lymph nodes and lung. Lymphatic endothelial cells promote the migratory activity of a CD133+ subset to target organs and regulation of lymphatic growth efficiently modulates the metastasis of CD133+ tumor cells. We found that lymphatic vessels in metastatic tissues stimulate chemokine receptor 4 (CXCR4)+/CD133+ cell metastasis to target organs by secretion of stromal cell–derived factor-1 (SDF-1). The CXCR4+/CD133+ cells exhibited higher metastatic activity compared with CXCR4−/CD133+ cells and, importantly, blockade of CXCR4 coupled with dacarbazine efficiently inhibited both tumor growth and metastasis; dacarbazine alone could not attenuate tumor metastasis. The current study demonstrates a previously unidentified role of the lymphatic microenvironment in facilitating metastasis of chemoresistant melanoma cells via a specific chemotactic axis, SDF-1/CXCR4. Our findings suggest that targeting the SDF-1/CXCR4 axis in addition to dacarbazine treatment could therapeutically block chemoresistant CD133+ cell metastasis toward a lymphatic metastatic niche. Cancer Res; 70(24); 10411–21. ©2010 AACR.
Councils without Customs, Qadis without States: Property and Community in the Algerian Touat
Authors: Scheele Judith 
Published: November 2010

AbstractThis article investigates relations between qadis and local assemblies in the Touat in the Algerian Sahara. It argues that both drew on an Islamic framework of reference, even though they were frequently obliged to conjugate universal legal injunctions with local notions of overriding communal responsibility that had no place in Islamic law. Islamic notions of private property remained central to the functioning of local assemblies, in which political rights depended on ownership rather than residence. Meanwhile, qadis necessarily relied on the assembly as a source of expertise, for the validation of documents and judgments, and for political and at times also financial backing. Tensions did occur between individual rights of ownership and collective responsibilities, but assemblies and qadis tended to deal with them in similar ways.
Rhipicephalus microplus salivary gland molecules induce differential CD86 expression in murine macrophages
Authors: Brake Danett K , Wikel Stephen K , Tidwell Jason P , Pérez de León Adalberto A 
Published: November 2010

Abstract

Background
Tick parasitism is a major impediment for cattle production in many parts of the world. The southern cattle tick, Rhipicephalus (Boophilus) microplus, is an obligate hematophagous parasite of domestic and wild animals that serves as vector of infectious agents lethal to cattle. Tick saliva contains molecules evolved to modulate host innate and adaptive immune responses which facilitates blood feeding and pathogen transmission. Tick feeding promotes CD4 T cell polarization to a Th2 profile usually accompanied by down-regulation of Th1 cytokines through as yet undefined mechanisms. Co-stimulatory molecules on antigen presenting cells are central to development of T cell responses including Th1 and Th2 responses. Tick induced changes to antigen presenting cell signal transduction pathways are largely unknown. Here we document the ability of R. microplus salivary gland extracts (SGE) to effect differential CD86 expression.

Results
We examined changes in co-stimulatory molecule expression in murine RAW 264.7 cells in response to R. microplus SGE exposure in the presence of the toll-like receptor 4 (TLR4) ligand, LPS. After 24 hrs, CD86, but not CD80, was preferentially up-regulated on mouse macrophage RAW 264.7 cells when treated with SGE and then LPS, but not SGE alone. CD80 and CD40 expression was increased with LPS, but the addition of SGE did not alter expression. Higher concentrations of SGE were less effective at increasing CD86 RNA expression. The addition of mitogen or extracellular kinase (MEK) inhibitor, PD98059, significantly reduced the ability for SGE to induce CD86 expression, indicating activation of MEK is necessary for SGE induced up-regulation.

Conclusions
Molecules in SGE of R. microplus have a concentration-dependent effect on differential up-regulation of CD86 in a macrophage cell line activated by the TLR4 ligand, LPS. This CD86 up-regulation is at least partially dependent on the ERK1/2 pathway and may serve to promote Th2 polarization of the immune response.
Resting in Peace? Regulating the Geological Storage of Radioactive Waste and Carbon Dioxide: Swedish and European Perspectives
Authors: Langlet David 
Published: November 2010

AbstractCarbon capture and storage or sequestration (CCS) and production of nuclear energy are both associated with potentially hazardous geological disposal or storage operations (of captured carbon dioxide [CO2] and spent nuclear fuel, respectively). Using Sweden as a focal point, applicable domestic, EU, and international rules affecting site selection and the nature and allocation of responsibility for long‐term hazard management are compared and analyzed in this article. It is inter alia concluded that the legal terminology is partly misleading and that there are many similarities, but also some significant differences, with respect to spatial and temporal aspects of risks and benefits. Whereas disposal of spent nuclear fuel is mainly the reserve of domestic law, storage of CO2 is the subject of extensive EU regulation. With neither activity is the operator expected to pay for supervision of storage/disposal sites or remedial action for any extensive period of time, though the CCS regime is slightly more in keeping with the polluter pays principle. Neither regulatory framework purports to guarantee funds, knowledge, or technology to address problems that may arise beyond some decades into the future.
New Perspectives on Nuclear Waste Management
Authors: Jenkins‐Smith Hank C , Strandberg Urban , Trousset Sarah R 
Published: November 2010

AbstractThis paper outlines the evolution of the global public policy debate concerning the management and disposal of used nuclear fuel, with particular attention to the central points of contention that have shaped that debate. Utilizing the experience in Sweden and the U.S., we provide a frame for the application of a diverse range of social science perspectives (including law) to the used nuclear fuel policy debate, and introduce a set of papers that apply those perspectives.
SIL-based confocal fluorescence microscope for investigating individual nanostructures
Authors: Krajnik Bartosz , Schulte Tim , Piątkowski Dawid , Czechowski Nikodem , Hofmann Eckhard , Mackowski Sebastian 
Published: November 2010

Abstract
We developed a fluorescence confocal microscope equipped with a hemispherical solid immersion lens (SIL) and apply it to study the optical properties of light-harvesting complexes. We demonstrate that the collection efficiency of the SIL-equipped microscope is significantly improved, as is the spatial resolution, which reaches 600 nm. This experimental setup is suitable for detailed studies of physical phenomena in hybrid nanostructures. In particular, we compare the results of fluorescence intensity measurements for a light-harvesting peridinin-chlorophyll-protein (PCP) complex with and without the SIL.
Assembly of uniform photoluminescent microcomposites using a novel micro‐fluidic‐jet‐spray‐dryer
Authors: Wu Winston Duo , Amelia Ria , Hao Na , Selomulya Cordelia , Zhao Dongyuan , Chiu Yu‐Lung , Chen Xiao Dong 
Published: November 2010

AbstractGeneration of uniform micro‐particles containing (i) pure lactose; (ii) silica nanoparticles and lactose; (iii) silica nanoparticles/lactose doped with Eu(III) have been successfully achieved using a novel spray dryer with a uniquely designed microfluidic aerosol nozzle as the monodisperse droplet generator. Here we investigate the impacts of precursor compositions and concentrations, as well as the drying temperature profile on particle size, morphology, and surface element distribution. Distinct morphologies are observed with different precursor compositions, ranging from smooth spherical lactose microparticles to the buckled shape for composites containing silica nanoparticles. The formation of such morphology is qualitatively interpreted by using Peclet number, indicating that the presence of the suspended silica nanoparticles facilitates shell formation at the early stage of the drying process. As the drying continue, such shell is subject to buckling, induced by the capillary force due to the lower mechanical integrity inside the droplet. Post calcination, transmission electron micrographs of Eu(III)/silica nanoparticles/lactose microcomposites confirm the formation of nano‐sized Eu2O3 homogeneously embedded on the silica shell. Photoluminescence spectra of these particles indicate that enhancement of photoluminescence intensity is directly related to the europium loading, which could be adjusted from the precursor composition. This work demonstrates a scalable route to assemble relatively complex composites with uniform properties, without extensive conjugation or purification steps commonly required in wet chemistry‐based processes. © 2011 American Institute of Chemical Engineers AIChE J, 2011
Difference in outcome among women and men after percutaneous mitral valvuloplasty
Authors: Cruz‐Gonzalez Ignacio , Jneid Hani , Sanchez‐Ledesma Maria , Cubeddu Roberto J. , Martin‐Moreiras Javier , Rengifo‐Moreno Pablo , Diaz Tullio A. , Kiernan Thomas J. , Inglessis‐Azuaje Ignacio , Maree Andrew O. , Sanchez Pedro L. , Palacios Igor F. 
Published: November 2010

AbstractObjective: To analyze the differences in anatomical, clinical and echocardiographic characteristics of women and men undergoing PMV and to evaluate the relationship between sex, PMV success, and immediate and long‐term clinical outcome. Background: Rheumatic mitral stenosis (MS) is predominantly a disease of middle‐aged women. Percutaneous mitral valvuloplasty (PMV) has become the standard of care for suitable patients. However little is known about the relationship between sex, PMV success, and procedural outcome. Methods and results: We evaluated measures of procedural success and clinical outcome in consecutive patients (839 women and 176 men) who underwent PMV. Despite a lower baseline echocardiographic score (7.47 ± 2.15 vs. 8.02 ± 2.18, P = 0.002), women were less likely to achieve PMV success (69% vs. 83%, adjusted OR 0.44, 95% CI 0.27–0.74, P = 0.002), and had a smaller post‐procedural MV area (1.86 ± 0.7 vs. 2.07 ± 0.7 cm2, P < 0.001). Overall procedural and in‐hospital complication rates did not differ significantly between women and men. However, women were significantly more likely to develop severe MR immediately post PMV (adjusted OR 2.41, 95% CI 1.0–5.83, P = 0.05) and to undergo MV surgery (adjusted HR 1.54, 95% CI 1.03–2.3, P = 0.037) after a median follow‐up of 3.1 years. Conclusions: Compared to men, women with rheumatic MS who undergo PMV are less likely to have a successful outcome and more likely to require MV surgery on long‐term follow‐up despite more favorable baseline MV anatomy. © 2010 Wiley‐Liss, Inc.
Solvent‐ and Guest‐Responsive Self‐Assembly of Hamilton Receptor Tethered Bis(merocyanine) Dyes
Authors: Schmidt Ralf , Uemura Shinobu , Würthner Frank 
Published: November 2010

AbstractA novel supramolecular building block (8) that consists of a Hamilton receptor and two merocyanine dyes has been synthesized, and the self‐assembly based on orthogonal hydrogen bonding and dipolar interactions has been studied in detail. Different self‐assembled species, including oligomers, polymers, and inverted micelles could be observed upon variation of the solvent polarity and the concentration. Moreover, this system is highly responsive toward molecular stimuli such as merocyanine molecules with the barbituric acid motif that are bound by the Hamilton receptors. Detailed UV/Vis absorption studies provided insight into isodesmic or cooperative steps during the self‐assembly of 8 into different species. The size of the aggregates in solution and the morphology on substrates have been explored by a combination of dynamic light scattering (DLS), atomic force microscopy (AFM), and TEM investigations.
ChemInform Abstract: Influence of Hydrogen Absorption on Structural and Magnetic Properties of Ce2Ni2In.
Authors: Iwasieczko Waclaw , Kaczorowski Dariusz 
Published: November 2010

AbstractCe2Ni2InHx hydrides with x < 2 retain the Mo2FeB2‐type structure of Ce2Ni2In and crystallize in the tetragonal space group P4/mbm (powder XRD).
ChemInform Abstract: Controlled Synthesis and Characterization of LaPO4, LaPO4:Ce3+ and LaPO4:Ce3+, Tb3+ by EDTA Assisted Hydrothermal Method.
Authors: Dong Hongxing , Liu Yanchao , Yang Piaoping , Wang Wenxin , Lin Jun 
Published: November 2010

AbstractLaPO4, LaPO4:Ce3+ and LaPO4:Ce3+,Tb3+ phosphors are synthesized by an EDTA assisted hydrothermal method from La2O3 and (NH4)2PO4 solutions (autoclave, 160 °C, 24 h).
ChemInform Abstract: The Last of the Five: The Elusive “Tantalum(III) Bromide”, a Perovskite‐Related Salt, [{Ta6}Br12]Br3 [TaBr6]0.86.
Authors: Habermehl Katja , Mudring Anja‐Verena , Meyer Gerd 
Published: November 2010

AbstractBlack cube‐like single crystals of the title compound are prepared from TaBr5 in a NaBr or RbBr flux (tantalum container, 500 °C, 5 d).
ChemInform Abstract: Unsaturated β‐Ketoesters as Versatile Electrophiles in Organocatalysis.
Authors: Piovesana Susy , Scarpino Schietroma Daniele M. , Tulli Ludovico G. , Monaco Mattia R. , Bella Marco 
Published: November 2010

AbstractThe quinine‐catalyzed Michael reaction of ketoesters (I) and (IV) with nitroalkanes proceeds in a stereoselective manner to afford adducts (III) and (VI).
ChemInform Abstract: Regioselective Functionalization of Alkanes by Sequential Dehydrogenation—Hydrozirconation.
Authors: Kuninobu Yoichiro , Ureshino Tomonari , Yamamoto Shun‐ichi , Takai Kazuhiko 
Published: November 2010

AbstractThe iridium‐catalyzed dehydrogenation of alkanes followed by hydrozirconation of the resulting mixture of alkenes leads to isomerized 1‐alkylzirconocene intermediates, which can be readily trapped by different electrophiles.
ChemInform Abstract: Catalyzed Synthesis of β‐Amino Acids Esters.
Authors: Dokichev T. V. , Latypova D. R. , Shakirov R. R. , Biglova R. Z. , Talipov R. F. 
Published: November 2010

AbstractA Kuganak montmorillonite that contains relatively high amount of TiO2 is used as catalyst for the Michael addition.
ChemInform Abstract: Amide Activation by Tf2O: Reduction of Amides to Amines by NaBH4 under Mild Conditions.
Authors: Xiang Shao‐Hua , Xu Jian , Yuang Hong‐Qiu , Huang Pei‐Qiang 
Published: November 2010

AbstractThe reaction of triflic anhydride with amides generates a highly electrophilic iminium triflate intermediate which is reduced by NaBH4 to give the target amines.
ChemInform Abstract: Environmentally Benign Regio‐ and Stereoselective Synthesis of Functionalized Tertiary Amines.
Authors: Wang Rendong , Li Jian , Li Chunju , Liu Jun , Li Dafeng , Jia Xueshun , Zhai Hongbin 
Published: November 2010

AbstractBaylis—Hillman adducts (I) react regio‐ and stereoselectively with various primary aliphatic amines under neat conditions to potentially valuable building blocks containing reactive C—C double bonds and an ester and cyano group, respectively.
ChemInform Abstract: An Efficient and Selective Method for the Preparation of Triphenylmethyl Ethers of Alcohols and Nucleosides.
Authors: Zekri Negar , Alamdari Reza Fareghi 
Published: November 2010

AbstractA simple and efficient method for the trityl protection of primary, secondary and tertiary alcohols is presented, involving their reaction with trityl benzyl ethers in a DEAD—Ce(O‐Tf)4 catalyst system.
ChemInform Abstract: One‐Pot Approach for C—C Bond Formation Through Ruthenium‐Amido Complex Catalyzed Tandem Aldol Reaction/Hydrogenation.
Authors: Sun Haifeng , Ye Deju , Jiang Hualiang , Chen Kaixian , Liu Hong 
Published: November 2010

AbstractThe procedure is highly suitable for the transformation of aromatic aldehydes and tolerates a broad spectrum of functionalities.
ChemInform Abstract: Synthesis of (Z)‐1‐Benzylidene‐3‐(1H‐indol‐1‐yl)‐1H‐indene‐2,2(3H)‐dicarbonitriles via Three‐Component Reaction of 2‐Alkynylbenzaldehyde, Malononitrile, and Indole.
Authors: Qiu Guanyingsheng , Ding Qiuping , Peng Yiyuan , Wu Jie 
Published: November 2010

AbstractThe reaction proceeds highly selectively and might involve tandem condensation, nucleophilic addition and intramolecular 5‐exo‐cyclization.
ChemInform Abstract: Palladium‐Catalyzed Three‐Component Cyclization: Synthesis of Hydroisoindol‐1‐ones from 2‐Bromocyclohex‐1‐enecarbaldehydes, Anilines and Carbon Monoxide.
Authors: Cho Chan Sik , Kim Hyo Bo , Lee Sang Yeon 
Published: November 2010

AbstractPalladium‐catalyzed cyclocarbonylation of bromocyclohexenylcarbaldehydes (I), (V) and (VII) with anilines under CO atmosphere proceeds smoothly for a range of aniline derivatives to give title hydroisoindolones in moderate to good yields.
ChemInform Abstract: Orthogonal Regioselective Synthesis of N‐Alkyl‐3‐substituted Tetrahydroindazolones.
Authors: Kim Jonghoon , Song Heebum , Park Seung Bum 
Published: November 2010

AbstractTwo regioisomers of title N,3‐disubstituted tetrahydroindazolones are synthesized with excellent selectivity.
ChemInform Abstract: Synthesis of 2,5,6‐Trisubstituted Benzimidazoles by Heck and Subsequent 6π‐Electrocyclization—Dehydrogenation Reactions of 2,4,5‐Tribromo‐N‐methylimidazole and 2‐Aryl‐4,5‐dibromo‐N‐methylimidazole.
Authors: Toguem Serge Mitherand Tengho , Langer Peter 
Published: November 2010

AbstractHeck reaction of tribromo imidazoles (I) and dibromo analogues (VI), obtained by arylation of (I), with vinyl compounds produces dialkenyl imidazoles which undergo 6π‐electrocyclization—dehydration to give the title benzimidazoles.
ChemInform Abstract: Facile One‐Pot Synthesis of Three Different Substituted Thiazoles from Propargylic Alcohols.
Authors: Gao Xun , Pan Ying‐ming , Lin Min , Chen Li , Zhan Zhuang‐ping 
Published: November 2010

AbstractA wide range of secondary and tertiary propargylic alcohols reacts smoothly with aromatic and aliphatic thioamides under Ag catalysis to give thiazole derivatives substituted at positions 2, 4, and 5.
ChemInform Abstract: 1,2,4‐Triazole Synthesis via Amidrazones.
Authors: El Kaim Laurent , Gizzi Marion , Grimaud Laurence 
Published: November 2010

AbstractThe optimized one‐pot two‐step procedure allows the preparation of various 1,2,4‐triazoles from aromatic amides and phenylhydrazine via an amidrazone intermediate [cf (III)].
ChemInform Abstract: Synthesis of Substituted 3‐Chloro‐1‐(3‐ (trifluoromethyl)‐5‐methoxy‐4H‐1,2,4‐triazol‐4‐yl) ‐4‐phenylazetidin‐2‐ones.
Authors: Paliwal Rakesh , Sekhar K. Chandra , Taneja Amit , Mishra S. K. 
Published: November 2010

AbstractMost of the title compounds (VII) exhibit moderate antibacterial activities, but only compound (VIIc) possesses moderate antifungal activities.
ChemInform Abstract: Skeletal Diversity via Cationic Rearrangements of Substituted Dihydropyrans.
Authors: Medeiros Matthew R. , Narayan Radha S. , McDougal Nolan T. , Schaus Scott E. , Porco John A. Jr. 
Published: November 2010

AbstractBenzyloxy‐substituted dihydropyrans undergo acid‐catalyzed rearrangement to provide highly functionalized isochroman scaffolds.
ChemInform Abstract: Synthesis of Substituted 4‐Pyridones and 4‐Aminopyridinium Salts via a One‐Pot Pyridine Synthesis.
Authors: Andersson Hans , Das Sajal , Gustafsson Magnus , Olsson Roger , Almqvist Frederik 
Published: November 2010

AbstractAddition of Grignard reagents to N‐oxides (I) provides pyridines (III) which are further converted into pyridones (V) and 4‐aminopyridinium salts (VI) upon treatment with NaOH and NH3, respectively.
ChemInform Abstract: Tandem Asymmetric Michael Reaction—Intramolecular Michael Addition. An Easy Entry to Chiral Fluorinated 1,4‐Dihydropyridines.
Authors: Fustero Santos , Catalan Silvia , Sanchez‐Rosello Maria , Simon‐Fuentes Antonio , del Pozo Carlos 
Published: November 2010

AbstractThe sequential treatment of optically active sulfoxide (I) with fluorinated nitriles and alkyl propiolates affords (sulfinylmethyl)dihydropyridines of type (IV) as single diastereomers in most cases.
ChemInform Abstract: One‐Pot Multicomponent Synthetic Route for New Quinolidinyl 2,4‐Thiazolidinediones (IV)
Authors: Mali Jyotirling R. , Bhosle Manisha R. , Mahalle Shital R. , Mane Ramrao A. 
Published: November 2010

Abstractunder microwave irradiation conditions using polyethylene glycol 400 as reaction medium and catalyst
ChemInform Abstract: Phosphomolybdic Acid (PMA)—SiO2 as a Heterogeneous Solid Acid Catalyst for the One‐Pot Synthesis of 2H‐Indazolo[1,2‐b]phthalazine‐triones.
Authors: Sabitha Gowravaram , Srinivas Chitti , Raghavendar Avula , Yada Jhillu Singh 
Published: November 2010

AbstractAdvantages of this method are its generality, short reaction time, easy workup, and ease of recovery and reuse of the catalyst.
ChemInform Abstract: Primary Amine Catalyzed Biginelli Reaction for the Enantioselective Synthesis of 3,4‐Dihydropyrimidin‐2(1H)‐ones.
Authors: Ding Derong , Zhao Cong‐Gui 
Published: November 2010

AbstractBiginelli reaction of acetoacetate (I) with urea (II) and aromatic or aliphatic aldehydes proceeds smoothly in the presence of a quinidine‐derived primary amine (QDA) as organocatalyst to give the title dihydropyrimidinones (IV) and (VI), resp., in up to 78% optical purity.
ChemInform Abstract: Synthesis of 3‐Aryl‐4(3H)‐quinazolinones from Anthranilic Acid, Orthoesters, and Anilines Using Ce(CH3SO3)3·2H2O as Catalyst.
Authors: Wang Min , Song Zhi‐Guo , Zhang Ting‐Ting 
Published: November 2010

AbstractThe catalyst can be recovered and reused for three consecutive runs without significant loss of activity.
ChemInform Abstract: A Highly Efficient Method for the N‐Alkylation of Aminopyrazines: Synthesis of Hydrophilic Red Fluorescent Dyes.
Authors: Poreddy Amruta R. , Asmelash Bethel , Neumann William L. , Dorshow Richard B. 
Published: November 2010

AbstractN,N′‐Dialkylated aminopyrazines of type (V) are easily prepared by reductive alkylation with different aldehydes.
ChemInform Abstract: One‐Pot Synthesis of Quinoxaline‐2‐carboxylate Derivatives Using Ionic Liquid as Reusable Reaction Media.
Authors: Mershram H. M. , Ramesh P. , Kumar G. Santosh , Reddy B. Chennakesava 
Published: November 2010

AbstractThe condensation of β‐halo‐ketoesters with 1,2‐diamines proceeds under mild conditions in [bmim]BF4.
ChemInform Abstract: Synthesis of New 5‐Acetyl(arylmethyliden)‐4‐thiazolidones.
Authors: Polovkovych Svyatoslav V. , Karkhut Andrii I. , Marintsova Natalia G. , Novikov Volodymyr P. 
Published: November 2010

AbstractA variety of new compounds having a triazine and a 4‐thiazolidinone moiety [cf.
ChemInform Abstract: Synthesis and Structure of Dimethyl 3,6‐Diphenyl‐1,2‐dihydro‐1,2,4,5‐tetrazine‐1,2‐dicarboxylate.
Authors: Rao Guo‐Wu , Lu Xiao‐Jing , Hu Wei‐Xiao 
Published: November 2010

AbstractIn connection with the preparation of biologically interesting derivatives, treatment of substrate (I) with ester (II) is investigated.