bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYP3A4 inhibitors may influence the quantification of [123I]I-FP-CIT SPECT scans
Authors: Booij Jan , Yağci Eda , Sheikh Zulfiqar H , Chahid Youssef 
Published: May 2024

Abstract
Purpose
[123I]I-FP-CIT SPECT is an imaging tool to support the diagnosis of parkinsonian syndromes characterized by nigrostriatal dopaminergic degeneration. After intravenous injection, [123I]I-FP-CIT is metabolized for a small part by the enzyme CYP3A4, leading to the formation of [123I]I-nor-β-CIT. [123I]I-nor-β-CIT passes the blood-brain barrier and has a very high affinity for the serotonin transporter (SERT). The SERT is expressed in the striatum and cortical areas. So, at least theoretical, the use of frequently used CYP3A4 inhibitors (like amiodarone) may influence the specific to non-specific striatal [123I]I-FP-CIT ratio. Here we tested this novel hypothesis.

Methods
Using a retrospective design, we determined the specific to non-specific striatal [123I]I-FP-CIT ratio (using BRASS software) in 6 subjects that were using an CYP3A4 inhibitor and 18 matched controls. Only subjects were included with a normal rated [123I]I-FP-CIT SPECT scan, and all participants were scanned on the same brain-dedicated SPECT system.

Results
The specific to non-specific (assessed in the occipital cortex) striatal [123I]I-FP-CIT binding ratio was significantly higher in CYP3A4 users than in the control group (3.52 ± 0.33 vs. 2.90 ± 0.78, p < 0.001).

Conclusion
Our preliminary data suggest that the use of CYP3A4 inhibitors may influence striatal [123I]I-FP-CIT binding ratios. This information, when reproduced in larger studies, may be relevant for studies in which quantification of [123I]I-FP-CIT SPECT imaging is used for diagnostic or research purposes.
The efficacy and safety of adding PD-1 blockade to induction chemotherapy and concurrent chemoradiotherapy (IC-CCRT) for locoregionally advanced nasopharyngeal carcinoma: an observational, propensity score-matched analysis
Authors: Jin Ya-Nan , Qiang Meng-Yun , Wang Ying , Lin Yu-Jing , Jiang Ren-Wei , Cao Wan-Wei , Zhang Wang-Jian , Wang Si-Yang , Zhang Hong-Yu , Yao Ji-Jin 
Published: May 2024

Abstract
Background
Despite the success of PD-1 blockade in recurrent/metastatic nasopharyngeal carcinoma (NPC), its effect for locoregionally advanced NPC (LANPC) remains unclear. This study aimed to evaluate the benefit of adding PD-1 blockade to the current standard treatment (gemcitabine and cisplatin IC <induction chemotherapy> plus cisplatin CCRT <concurrent chemoradiotherapy>) for LANPC patients.

Methods
From January 2020 to November 2022, 347 patients with non-metastatic high-risk LANPC (stage III-IVA, excluding T3-4N0) were included. Of the 347 patients, 268 patients were treated with standard treatment (IC-CCRT), and 79 received PD-1 blockade plus IC-CCRT (PD-1 group). For the PD-1 group, PD-1 blockade was given intravenously once every 3 weeks for up to 9 cycles (3 induction and 6 adjuvant). The primary endpoint was disease-free survival (DFS) (i.e. freedom from local/regional/distant failure or death). The propensity score matching (PSM) with the ratio of 1:2 was performed to control confounding factors.

Results
After PSM analysis, 150 patients receiving standard treatment and 75 patients receiving additional PD-1 blockade remained in the current analysis. After three cycles of IC, the PD-1 group had significantly higher rates of complete response (defined as disappearance of all target lesions; 24% vs. 9%; P = 0.006) and complete biological response (defined as undetectable cell-free Epstein-Barr virus DNA, cfEBV DNA; 79% vs. 65%; P = 0.046) than that in the standard group. And the incidence of grade 3–4 toxicity during IC was 47% in the PD-1 group and 41% in the standard group, with no significant difference (P = 0.396). During follow-up period, additional PD-1 blockade to standard treatment improved 3-year DFS from 84 to 95%, with marginal statistical significance (HR, 0.28; 95%CI, 0.06-1.19; P = 0.064).

Conclusion
Additiaonl PD-1 blockade to gemcitabine and cisplatin IC and adjuvant treatment results in significant improvement in tumor regression, cfEBV DNA clearance, superior DFS, and comparable toxicity profiles in high-risk LANPC patients.
The failure of biological treatment in axial spondyloarthritis is linked to the factors related to increased intestinal permeability and dysbiosis: prospective observational cohort study
Authors: Chmielińska Magdalena , Felis-Giemza Anna , Olesińska Marzena , Paradowska-Gorycka Agnieszka , Szukiewicz Dariusz 
Published: May 2024

Abstract
Background
A significant number of patients with axial spondyloarthritis (axSpA) do not respond to biological therapy. Therefore, we decided to investigate the specificity of this group of patients and, in particular, whether haptoglobin (Hp), its polymorphism and zonulin, in addition to other clinical features, are predictors of poor response to biological treatment.

Methods
48 patients with axSpA who were unsuccessfully treated with standard drugs were converted to biological treatment, and from this time on, a 12-week follow-up was started to assess the failure of biological treatment (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) decrease < 2 points). Predictors of treatment failure were identified using logistic regression analysis.

Results
21% of subjects had biological treatment failure. Patients who had a higher zonulin level, a history of frequent infections, were older, had inflammatory bowel disease (IBD), had a lower Hp level at the time of inclusion in biological therapy showed an increased risk of treatment failure.

Conclusions
The results of the study support the hypothesis that the effectiveness of biological treatment of axSpA is limited by changed microbiota and intestinal epithelial barrier dysfunction, as an increased risk of biological treatment failure was observed in patients who were older, had higher zonulin level, IBD and repeated courses of antibiotics due to frequent infections. Therefore, starting biological treatment should be followed by reducing intestinal permeability and regulating the disturbed gut microbiome.
Evaluation of the convection permitting regional climate model CNRM-AROME on the orographically complex island of Corsica
Authors: Cortés-Hernández Virginia Edith , Caillaud Cécile , Bellon Gilles , Brisson Erwan , Alias Antoinette , Lucas-Picher Philippe 
Published: May 2024

AbstractMeteorological processes over islands with complex orography could be better simulated by Convection Permitting Regional Climate Models (CP-RCMs) thanks to an improved representation of the orography, land–sea contrasts, the combination of coastal and orographic effects, and explicit deep convection. This paper evaluates the ability of the CP-RCM CNRM-AROME (2.5-km horizontal resolution) to simulate relevant meteorological characteristics of the Mediterranean island of Corsica for the 2000–2018 period. These hindcast simulations are compared to their driving Regional Climate Model (RCM) CNRM-ALADIN (12.5-km horizontal resolution and parameterised convection), weather stations for precipitation and wind and gridded precipitation datasets. The main benefits are found in the representation of (i) precipitation extremes resulting mainly from mesoscale convective systems affected by steep mountains during autumn and (ii) the formation of convection through thermally induced diurnal circulations and their interaction with the orography during summer. Simulations of hourly precipitation extremes, the diurnal cycle of precipitation, the distribution of precipitation intensities, the duration of precipitation events, and sea breezes are all improved in the 2.5-km simulations with respect to the RCM, confirming an added value. However, existing differences between model simulations and observations are difficult to explain as the main biases are related to the availability and quality of observations, particularly at high elevations. Overall, better results from the 2.5-km resolution, increase our confidence in CP-RCMs to investigate future climate projections for Corsica and islands with complex terrain.
Clinical evaluation of a machine learning-based dysphagia risk prediction tool
Authors: Gugatschka Markus , Egger Nina Maria , Haspl K. , Hortobagyi David , Jauk Stefanie , Feiner Marlies , Kramer Diether 
Published: May 2024

Abstract
Purpose
The rise of digitization promotes the development of screening and decision support tools. We sought to validate the results from a machine learning based dysphagia risk prediction tool with clinical evaluation.

Methods
149 inpatients in the ENT department were evaluated in real time by the risk prediction tool, as well as clinically over a 3-week period. Patients were classified by both as patients at risk/no risk.

Results
The AUROC, reflecting the discrimination capability of the algorithm, was 0.97. The accuracy achieved 92.6% given an excellent specificity as well as sensitivity of 98% and 82.4% resp. Higher age, as well as male sex and the diagnosis of oropharyngeal malignancies were found more often in patients at risk of dysphagia.

Conclusion
The proposed dysphagia risk prediction tool proved to have an outstanding performance in discriminating risk from no risk patients in a prospective clinical setting. It is likely to be particularly useful in settings where there is a lower incidence of patients with dysphagia and less awareness among staff.
Rhinitis medicomentosa and substance addiction
Authors: Birinci Mehmet , Ozdemir Dogukan , Pusuroglu Meltem , Sevim Ömer , Yemiş Tuğba , Cihan Seda Nur , Yılmaz Esra , Çeliker Metin , Çelebi Erdivanlı Özlem 
Published: May 2024

Abstract
Background
Rhinitis medicomentosa (RM) is a form of non-allergic rhinitis caused by the use of nasal decongestants for longer than the recommended duration. Because of this problem of use, addiction to the drug occurs in individuals. In our study, we aimed to evaluate the susceptibility of RM patients to substance addiction.

Methods
The study was planned as a prospective, multicentric study between September 2022 and September 2023. Patients diagnosed with RM were included in the study. Beck depression scale, Drug use disorders identification test, Substance Abuse Proclivity Scale were applied to the patients participating in the study. The research data were analyzed electronically with SPSS program version 25.

Results
The study included 86 patients with an average age of 31 years. The average duration of medication use was 22 months. Age, gender, duration of nasal congestion, duration of drug use and smoking were not independent predictors for depression and substance use tendency.

Conclusion
The relationship between RM and addictive substances is not clear. The tendency to use drugs did not increase in RM patients. In the light of these data, we think that there is no need for a practice other than routine functioning in the use of drugs and similar substances that are likely to cause addiction in RM patients.
Studying eruption patterns of mandibular third molars for forensic age assessment: Introducing current reference data from a population of black South Africans
Authors: Timme Maximilian , Viktorov Jan , Steffens Laurin , Streeter Adam , Karch André , Smit Chané , Robinson Liam , Bernitz Herman , Schmeling Andreas 
Published: May 2024

Abstract
Introduction
Evaluation of the eruption of mandibular third molars in orthopantomograms (OPGs) is a method of forensic age assessment. The objective of our study was to provide valid reference data for this trait within a population of black South Africans. The study was guided by the criteria for reference studies in age assessment.

Materials and methods
A study population from Pretoria, South Africa comprising 670 OPGs obtained from 338 black females and 332 black males aged between 15.00 and 25.97 years was analysed. All OPGs were performed for medical indication during the period from 2011 to 2022 and were retrospectively evaluated. From the 670 OPGs, a total of 1021 mandibular third molars were evaluated. The assessment of mandibular third molars was conducted using the staging scale presented by Olze et al. in 2012. Two experienced dentists evaluated the OPGs independently of each other. If the two examiners diverged in their assessments, a consensus stage was assigned.

Results
As expected, the mean, median and minimal age increased with higher stages for both teeth and both sexes. The minimum age recorded for stage D, indicating complete tooth eruption, was 15.79 years in females and 16.62 years in males.

Conclusion
As it is the case for previous reference studies in other countries, placing exclusive reliance on the evaluation of mandibular third molar eruption is inadequate for ascertaining the age of majority among Black South Africans. Future studies need to examine if our results are transferable to other countries in Sub-Saharan Africa.
JEWELFISH: 24-month results from an open-label study in non-treatment-naïve patients with SMA receiving treatment with risdiplam
Authors: Chiriboga Claudia A. , Bruno Claudio , Duong Tina , Fischer Dirk , Mercuri Eugenio , Kirschner Janbernd , Kostera-Pruszczyk Anna , Jaber Birgit , Gorni Ksenija , Kletzl Heidemarie , Carruthers Imogen , Martin Carmen , Scalco Renata S. , Fontoura Paulo , Muntoni Francesco ,   the JEWELFISH Study Group
Published: May 2024

Abstract
Risdiplam is a once-daily oral, survival of motor neuron 2 (SMN2) splicing modifier approved for the treatment of spinal muscular atrophy (SMA). JEWELFISH (NCT03032172) investigated the safety, tolerability, pharmacokinetics (PK), and PK/pharmacodynamic (PD) relationship of risdiplam in non-treatment-naïve patients with SMA. JEWELFISH enrolled adult and pediatric patients (N = 174) with confirmed diagnosis of 5q-autosomal recessive SMA who had previously received treatment with nusinersen (n = 76), onasemnogene abeparvovec (n = 14), olesoxime (n = 71), or were enrolled in the MOONFISH study (NCT02240355) of the splicing modifier RG7800 (n = 13). JEWELFISH was an open-label study with all participants scheduled to receive risdiplam. The most common adverse event (AE) was pyrexia (42 patients, 24%) and the most common serious AE (SAE) was pneumonia (5 patients, 3%). The rate of AEs and SAEs decreased by > 50% from the first to the second year of treatment, and there were no treatment-related AEs that led to withdrawal from treatment. An increase in SMN protein in blood was observed following risdiplam treatment and sustained over 24 months of treatment irrespective of previous treatment. Exploratory efficacy assessments of motor function showed an overall stabilization in mean total scores as assessed by the 32-item Motor Function Measure, Hammersmith Functional Motor Scale—Expanded, and Revised Upper Limb Module. The safety profile of risdiplam in JEWELFISH was consistent with previous clinical trials of risdiplam in treatment-naïve patients. Exploratory efficacy outcomes are reported but it should be noted that the main aim of JEWELFISH was to assess safety and PK/PD, and the study was not designed for efficacy analysis.

Trial registration
The study was registered (NCT03032172) on ClinicalTrials.gov on January 24, 2017; First patient enrolled: March 3, 2017.
Assessing the quality of chest compressions with a DIY low-cost manikin (LoCoMan) versus a standard manikin: a quasi-experimental study in primary education
Authors: Peixoto-Pino Lucía , Isasi Santiago Martínez , Agra Martín Otero , Van Duijn Tina , Rico-Díaz Javier , Núñez Antonio Rodriguez , Furelos Roberto Barcala 
Published: May 2024

AbstractExtending the access to cardiopulmonary resuscitation (CPR) training to a wider public is an important step in increasing survivability of out-of-hospital cardiac arrest. However, often price and maintenance of CPR manikins are barriers that prevent training at schools. This study aims to evaluate the learning of hands-only (HO) CPR by practicing with a low-cost manikin (LoCoMan) with visual qualitative feedback and to compare the results with the skills acquired by practice on a conventional manikin. A quasi-experimental study with 193 schoolchildren (10 to 12 years old) who were allocated to two groups: the LoCoMan group was taught via an integrative approach (science combined with physical education (PE)) and practiced on a handmade manikin, and a control group practiced in a traditional setting with a commercial manikin (Resusci Junior, Laerdal, Norway). All participants practiced for 1 hands-on skill session before performing a post-test on an instrumented CPR manikin. The outcomes including HO-CPR performance variables were compared between groups. The LoCoMan and control groups both achieved acceptable percentage of HO-CPR quality (57% and 71%, p = 0.004). Among 6th-graders, there were no significant differences in HO-CPR quality between LoCoMan 68% and control 71%, p = 0.66. The control group achieved better chest compression depth while the LoCoMan group showed more compressions with adequate chest recoil. Conclusion: Schoolchildren are able to build and use a low-cost manikin with visual feedback. The integrative learning approach used in this study may be a feasible alternative methodology for training and learning HO-CPR in schools when commercial manikins are not available.

What is Known:• Access to CPR training should be universal and independent of age, location, financial means, or access to qualified instructors.• Scientific societies promote the implementation of CPR in schools, so that teachers and schoolchildren can play a multiplier role in their environment, but the gap in CPR learning is related to cultural, economic factors or access to resources and materials.

What is New:• LoCoMan may be a useful device for teaching and learning CPR in schoolchildren from the age of 10 and upwards.• LOCOMAN shows that it is feasible and possible to build a low-cost manikin (about €5 in the European Region) and to integrate it into an integrative educational project, and outlines how this could be done. this approach can be an incentive for teachers to attempt teaching CPR, but also for education outside the formal environment.
Updated dendrochronology and axial variation of climatic sensitivity in Sequoiadendron giganteum
Authors: Carroll Allyson L. , Sillett Stephen C. 
Published: May 2024

Abstract
Key message
Dendroclimatic sensitivity varies by axial position for Sequoiadendron giganteum: negative correlations with June temperature strengthen with height, while positive correlations with snow water are strongest in the lower trunk.
Increment cores collected along trunks of mature Sequoiadendron giganteum provide new and updated ring-width chronologies ideal for assessing how height above ground affects sensitivity of radial growth to climatic variation. Chronologies from 61 living trees at nine locations across the geographic distribution span 1973 yr. Analyses of subsets of 18–44 trees reveal that correlations between radial increments and climate (temperature, water availability) vary with axial position. Negative correlations with maximum and minimum June temperature intensify with height and are strongest at the highest position analyzed (60 m above ground). Sensitivity to the hydroclimate variable of April-1 snow water equivalent is stronger at lower trunk positions (10 m) compared to breast height or the upper trunk, and a similar relationship is identified for the standardized precipitation evapotranspiration index using a 12-month window ending in September. Drought-induced low-growth years computed as radial increment relative to the mean of 10 yr before and after are more weakly expressed at breast height compared to higher on the trunk (10–60 m). Analysis of regional upper (maximum core height = 87 m) versus lower trunk (above buttress) chronologies corroborate differing inter-annual correlations with climate depending on height above ground. Accounting for axial variation in dendroclimatic sensitivity can maximize the quality of environmental reconstructions using tree rings and improve biophysical understanding of Sequoiadendron, especially in the context of an increasingly arid climate.
Same-day discharge after percutaneous coronary procedures—Structured review and comprehensive meta-analysis
Authors: Brandt Mathias C. , Alber Hannes , Berger Rudolf , Binder Ronald K. , Mascherbauer Julia , Niessner Alexander , Schmid Martin , Wernly Bernhard , Frick Matthias ,   Austrian working group of interventional cardiology
Published: May 2024

SummaryIntroductionPercutaneous coronary intervention is a well-established revascularization strategy for patients with coronary artery disease. The safety and feasibility of performing these procedures on a same-day discharge basis for selected patients has been studied in a large number of mostly nonrandomized trials. An up to date literature review should focus on trials with radial access, representing the current standard for coronary procedures in Austria and other European countries.MethodsThe aim of this consensus statement is to review the most recent evidence for the safety and feasibility of performing same-day discharge procedures in selected patients. A structured literature search was performed using prespecified search criteria, focusing on trials with radial access procedures.ResultsA total of 44 clinical trials and 4 large meta-analyses were retrieved, spanning 21 years of clinical evidence from 2001 to 2022. The outcome data from a wide range of clinical settings were unanimous in showing no negative effect on early (24 h) or late (30 day) major adverse events after same-day discharge coronary procedures. Based on nine prospective trials a comprehensive meta-analysis was compiled. Using 1‑month major adverse events data the pooled odds ratio of same-day discharge versus overnight stay procedures was 0.66 (95% confidence interval, CI 0.35–01.24;p = 0.19; I20%), indicating a noninferiority in carefully selected patients.ConclusionOutcome data from same-day discharge coronary intervention trials with radial access confirm the robust safety profile showing no increase in the risk of major adverse events compared to overnight stay.
Same-day discharge after percutaneous coronary procedures—Consensus statement of the working group of interventional cardiology (AGIK) of the Austrian Society of Cardiology
Authors: Brandt Mathias C. , Alber Hannes , Berger Rudolf , Binder Ronald K. , Mascherbauer Julia , Niessner Alexander , Schmid Martin , Frick Matthias ,   the Austrian working group of interventional cardiology
Published: May 2024

Summary
Introduction
Percutaneous coronary intervention is a well-established revascularization strategy for patients with coronary artery disease. Recent technical advances such as radial access, third generation drug-eluting stents and highly effective antiplatelet therapy have substantially improved the safety profile of coronary procedures. Despite several practice guidelines and a clear patient preference of early hospital discharge, the percentage of coronary procedures performed in an outpatient setting in Austria remains low, mostly due to safety concerns.

Methods
The aim of this consensus statement is to provide a practical framework for the safe and effective implementation of coronary outpatient clinics in Austria. Based on a structured literature review and an in-depth analysis of available practice guidelines a consensus statement was developed and peer-reviewed within the working group of interventional cardiology (AGIK) of the Austrian Society of Cardiology.

Results
Based on the available literature same-day discharge coronary procedures show a favorable safety profile with no increase in the risk of major adverse events compared to an overnight stay. This document provides a detailed consensus in various clinical settings. The most important prerequisite for same-day discharge is, however, adequate selection of suitable patients and a structured peri-interventional and postinterventional management plan.

Conclusion
Based on the data analysis this consensus document provides detailed practice guidelines for the safe operation of daycare cathlab programs in Austria.