bluuebunny/crossref_metadata_2025_split huggingface dataset:
SCANPatient: study protocol for a multi-centre, batched, stepped wedge, comparative effectiveness, randomised clinical trial of synoptic reporting of computerised tomography (CT) scans assessing cancers of the pancreas
Authors: Li Lin , Kasza Jessica , Recasens Ariadna , Ioannou Liane , Greenhill Elysia , Merrett Neil , Cavallucci David , Ellis Samantha , Madgwick Helen , Ko Hyun Soo , Chantrill Lorraine , Loveday Benjamin , Nikfarjam Mehrdad , Croagh Daniel , Yang Jessica , Dwyer Andrew , Zalcberg John , Pilgrim Charles ,   SCANPatient Authorship Group
Published: June 2024

Abstract
Background
Complete surgical removal of pancreatic ductal adenocarcinoma (PDAC) is central to all curative treatment approaches for this aggressive disease, yet this is only possible in patients technically amenable to resection. Hence, an accurate assessment of whether patients are suitable for surgery is of paramount importance. The SCANPatient trial aims to test whether implementing a structured synoptic radiological report results in increased institutional accuracy in defining surgical resectability of non-metastatic PDAC.

Methods
SCANPatient is a batched, stepped wedge, comparative effectiveness, cluster randomised clinical trial. The trial will be conducted at 33 Australian hospitals all of which hold regular multi-disciplinary team meetings (MDMs) to discuss newly diagnosed patients with PDAC. Each site is required to manage a minimum of 20 patients per year (across all stages). Hospitals will be randomised to begin synoptic reporting within a batched, stepped wedge design. Initially all hospitals will continue to use their current reporting method; within each batch, after each 6-month period, a randomly selected group of hospitals will commence using the synoptic reports, until all hospitals are using synoptic reporting. Each hospital will provide data from patients who (i) are aged 18 or older; (ii) have suspected PDAC and have an abdominal CT scan, and (iii) are presented at a participating MDM. Non-metastatic patients will be documented as one of the following categories: (1) locally advanced and surgically unresectable; (2) borderline resectable; or (3) anatomically clearly resectable (Note: Metastatic disease is treated as a separate category). Data collection will last for 36 months in each batch, and a total of 2400 patients will be included.

Discussion
Better classifying patients with non-metastatic PDAC as having tumours that are either clearly resectable, borderline or locally advanced and unresectable may improve patient outcomes by optimising care and treatment planning. The borderline resectable group are a small but important cohort in whom surgery with curative intent may be considered; however, inconsistencies with definitions and an understanding of resectability status means these patients are often incorrectly classified and hence overlooked for curative options.

Trial registration
The SCANPatient trial was registered on 17th May 2023 in the Australian New Zealand Clinical Trials Registry (ANZCTR) (ACTRN12623000508673).
Hepatic myelopathy neurological complication of chronic liver disease: two case reports
Authors: Mhiri Mariem , Ben Abdelwahed Mehdi , Dhiflaoui Mohamed Amine , Ben Dhia Rihab , Gouta Narjes , Jemni Imen , Baklouti Raoua , Zakhama Mejda , Gueddiche Arwa , Loghmari Mohamed Hichem , Ben Chaabene Nabil , Safer Leila , Frih-Ayed Mahbouba 
Published: June 2024

Abstract
Background
Hepatic myelopathy is a very rare neurological complication of chronic liver disease. Patients habitually present with progressive pure motor spastic paraparesis. This neurological dysfunction is almost always due to cirrhosis and portocaval shunt, either surgical or spontaneous.

Cases report
We report two cases of a 57-year-old man and a 37-year-old woman with progressive spastic paraparesis linked to cirrhosis and portal hypertension. The two patients are of Tunisian origin (north Africa). Magnetic resonance imaging of the spinal cord of two patients was normal, while brain magnetic resonance imaging showed a T2 hypersignals of the pallidums. These signs, in favor of hepatic encephalopathy in the two patients with cirrhosis with isolated progressive spastic paraparesis without bladder or sensory disorders, help to retain the diagnosis of hepatic myelopathy.

Conclusion
Hepatic myelopathy is a severe and debilitating neurological complication of chronic liver disease. The pathogenesis is misunderstood and seems to be multifactorial, including the selective neurotoxic role both of ammonia and other pathogenic neurotoxins. Usually a pathological brain magnetic resonance imaging showing a hepatic encephalopathy was documented, contrasting with a normal spinal cord magnetic resonance imaging that contributed to diagnosis of hepatic myelopathy. Conservative therapies such as ammonia-lowering measures, diet supplementation, antispastic drugs, and endovascular shunt occlusion show little benefit in improving disease symptoms. Liver transplantation performed at early stage can prevent disease progression and could probably allow for recovery.
Highly compact UWB-MIMO antenna with sharp multi-stop band characteristics
Authors: Pannu Preeti 
Published: June 2024

AbstractWith multi-band rejection characteristics, a new low-profile antenna of size 34 × 34 mm2 is conferred in this article. It consists of quad identical monopole elements (originated orthogonally), contributing ultra-wideband characteristics in the system. The single unit of the proposed design consists of a modified spinning-top shape radiator (MSTSR), excited by a tapered microstrip line feed (TMLF) and semi-circular ground. An excellent bandwidth of 3–12.9 GHz (where S11 < − 10 dB) is obtained at each port. By inserting the structure of four spiral coils, a sharp notch ranging from 7.9 to 8.5 GHz is achieved to filter the X-band satellite communication uplink. In addition, a circular spiral slot in the radiator near the ground plane creates a stop band at 7.35–7.565 GHz band (satellite communication downlink band). Furthermore, symmetrical rectangular trapezoid resonators and inverted symmetrical rectangular trapezoid structures near the feed line are responsible for the elimination of interferences at 5.5 GHz lower WLAN and 3.5 GHz WiMAX respectively. The FR-4 substrate used for the UWB-MIMO design fabrication process and fabricated results are found in good match with the simulated results. Also, the design provides good performance metrics such as total active reflection coefficient, diversity gain, channel capacity loss, isolation, and envelope correlation coefficient.
Remote expert viewing, laboratory tests or objective metrics: which one(s) to trust?
Authors: Wien Mathias , Jung Joel 
Published: June 2024

AbstractWe present a study on the validity of quality assessment in the context of the development of visual media coding schemes. The work is motivated by the need for reliable means for decision-taking in standardization efforts of MPEG and JVET, i.e., the adoption or rejection of coding tools during the development process of the coding standard. The study includes results considering three means: objective quality metrics, remote expert viewing, which is a method designed in the context of MPEG standardization, and formal laboratory visual evaluation. The focus of this work is on the comparison of pairs of coded video sequences, e.g., a proposed change and an anchor scheme at a given rate point. An aggregation of performance measurements across multiple rate points, such as the Bjøntegaard Delta rate, is out of the scope of this paper. The paper details the test setup for the subjective assessment methods and the objective quality metrics under consideration. The results of the three approaches are reviewed, analyzed, and compared with respect to their suitability for the decision-taking task. The study indicates that, subject to the chosen test content and test protocols, the results of remote expert viewing using a forced-choice scale can be considered more discriminatory than the results of naïve viewers in the laboratory tests. The results further that, in general, the well-established quality metrics, such as PSNR, SSIM, or MS-SSIM, exhibit a high rate of correct decision-making when their results are compared with both types of viewing tests. Among the learning-based metrics, VMAF and AVQT appear to be most robust. For the development process of a coding standard, the selection of the most suitable means must be guided by the context, where a small number of carefully selected objective metrics, in combination with viewing tests for unclear cases, appears recommendable.
Impact of LiDAR point cloud compression on 3D object detection evaluated on the KITTI dataset
Authors: Martins Nuno A. B. , Cruz Luís A. da Silva , Lopes Fernando 
Published: June 2024

AbstractThe rapid growth on the amount of generated 3D data, particularly in the form of Light Detection And Ranging (LiDAR) point clouds (PCs), poses very significant challenges in terms of data storage, transmission, and processing. Point cloud (PC) representation of 3D visual information has shown to be a very flexible format with many applications ranging from multimedia immersive communication to machine vision tasks in the robotics and autonomous driving domains. In this paper, we investigate the performance of four reference 3D object detection techniques, when the input PCs are compressed with varying levels of degradation. Compression is performed using two MPEG standard coders based on 2D projections and octree decomposition, as well as two coding methods based on Deep Learning (DL). For the DL coding methods, we used a Joint Photographic Experts Group (JPEG) reference PC coder, that we adapted to accept LiDAR PCs in both Cartesian and cylindrical coordinate systems. The detection performance of the four reference 3D object detection methods was evaluated using both pre-trained models and models specifically trained using degraded PCs reconstructed from compressed representations. It is shown that LiDAR PCs can be compressed down to 6 bits per point with no significant degradation on the object detection precision. Furthermore, employing specifically trained detection models improves the detection capabilities even at compression rates as low as 2 bits per point. These results show that LiDAR PCs can be coded to enable efficient storage and transmission, without significant object detection performance loss.
‘I take the drugs… to make the sickness to move out of me’: key populations’ and service provider perspectives about facilitators and barriers to ART adherence and retention in care in Nigeria
Authors: Dirisu Osasuyi , Eluwa George I. E. , Callens Steve , Adams Eseoghene , Akinwunmi Akinola , Geibel Scott , Iyortim Isa 
Published: June 2024

Abstract
Background
Adherence to antiretroviral therapy (ART) has individual and public health benefits and is critical to improving life expectancy, achieving viral suppression, and reducing the risk of HIV transmission. This qualitative study explored the experience of receiving care as well as perceived facilitators and barriers of treatment initiation, retention in ART care, and adherence to treatment.

Methods
In-depth interviews were conducted among 28 men who have sex with men (MSM) and female sex workers (FSWs) receiving ART services in Lagos and Benue states. Key informant interviews were also conducted among 16 service providers engaged in counselling, clinical care, and ART treatment for MSM and FSWs. The Social Ecology Model guided the exploration of perceived barriers and facilitators of treatment initiation, retention in ART care and adherence to treatment. Qualitative data analysis was managed using NVIVO 11 software and themes were analysed using thematic analysis.

Results
We found that the key barriers to ART adherence were low motivation to comply with medication regimen, work commitments, socioeconomic factors, stigma, negative provider attitude and distance to health facilities. Facilitators of adherence identified include the desire to live a productive life, strong family support and participation in support group programs. Comprehensive adherence counselling, support group programs and an effective follow-up system were factors identified by service providers as key to facilitating adherence.

Conclusion
To be effective, ART programs must address the unique challenges key populations face in accessing treatment and achieving optimal adherence regarding establishing a strong support system and follow-up. Community level interventions that support a stigma-free environment are critical to sustaining engagement in care.
Short-chain fatty acid valerate reduces voluntary alcohol intake in male mice
Authors: Bokoliya Suresh C. , Russell Jordan , Dorsett Yair , Panier Hunter A. , Singh Vijender , Daddi Lauren , Yuan Hanshu , Dedon Liv R. , Liu Zhongmao , Zhou Yuqi , Min Zefang , Barson Jessica R. , Covault Jonathan , Bubier Jason A. , Zhou Yanjiao 
Published: June 2024

Abstract
Background
Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. The development of novel therapeutic and preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between the gut microbiome and microbial metabolites with drinking behavior, but druggable targets and their underlying mechanism of action are understudied.

Results
Here, using a drink-in-the-dark mouse model, we identified a microbiome metabolite-based novel treatment (sodium valerate) that can reduce excessive alcohol drinking. Sodium valerate is a sodium salt of valeric acid short-chain fatty acid with a similar structure as γ-aminobutyric acid (GABA). Ten days of oral sodium valerate supplementation attenuates excessive alcohol drinking by 40%, reduces blood ethanol concentration by 53%, and improves anxiety-like or approach-avoidance behavior in male mice, without affecting overall food and water intake. Mechanistically, sodium valerate supplementation increases GABA levels across stool, blood, and amygdala. It also significantly increases H4 acetylation in the amygdala of mice. Transcriptomics analysis of the amygdala revealed that sodium valerate supplementation led to changes in gene expression associated with functional pathways including potassium voltage-gated channels, inflammation, glutamate degradation, L-DOPA degradation, and psychological behaviors. 16S microbiome profiling showed that sodium valerate supplementation shifts the gut microbiome composition and decreases microbiome-derived neuroactive compounds through GABA degradation in the gut microbiome.

Conclusion
Our findings suggest that sodium valerate holds promise as an innovative therapeutic avenue for the reduction of habitual binge drinking, potentially through multifaceted mechanisms.
Application of mendelian randomization in ocular diseases: a review
Authors: Zhang Xiran , Yuan Weichen , Xu Jun , Zhao Fangkun 
Published: June 2024

AbstractOcular disorders can significantly lower patients’ quality of life and impose an economic burden on families and society. However, for the majority of these diseases, their prevalence and mechanisms are yet unknown, making prevention, management, and therapy challenging. Although connections between exposure factors and diseases can be drawn through observational research, it is challenging to rule out the interference of confounding variables and reverse causation. Mendelian Randomization (MR), a method of research that combines genetics and epidemiology, has its advantage to solve this problem and thus has been extensively utilized in the etiological study of ophthalmic diseases. This paper reviews the implementation of MR in the research of ocular diseases and provides approaches for the investigation of related mechanisms as well as the intervention strategies.
Clinical care for severe and persistent eating disorders in pediatric populations: Perspectives of health professionals
Authors: Coelho Jennifer S. , Pardiwala Tanya , Marshall Sheila K. , Lam Pei-Yoong , Grewal Seena , Virani Alice , Olmos Pérez Alexandra , Geller Josie 
Published: June 2024

Abstract
Objective
Models of treatment for adults with severe and enduring eating disorders focus on harm reduction and improving quality of life. However, there is a notable gap in the pediatric literature in this area. The current study set out to assess the perspectives of health professionals regarding clinical care for young people (e.g., ages 10–25 years) with severe and enduring eating disorders, and to explore perceptions about appropriate treatment options for these presentations.

Methods
Health professionals were invited to complete a two-stage online survey about their experiences with clinical care for pediatric eating disorders through Canadian and Australian professional eating disorder networks. Survey 1 included questions about their experiences in supporting individuals with severe and enduring presentations. Participants who completed Survey 2 reviewed clinical vignettes and shared their perspectives about treatment recommendations and models of care, including for a severe and enduring presentation.

Results
A total of 85 clinicians responded to questions on Survey 1 about severe and enduring eating disorder presentations. A portion of these respondents (n = 25) also participated in Survey 2. The majority of respondents to Survey 1 reported providing clinical care for pediatric severe and enduring eating disorder presentations. Amongst respondents to Survey 2, there was low consensus amongst respondents for the clinical care that would be most appropriate for young people with a severe and enduring eating disorder presentation. Numerous challenges in models of care for severe and enduring presentations in pediatric settings were raised in responses on Survey 2, with clinicians sharing their awareness of models focusing on quality of life, while also raising concerns about the appropriateness of these models for young people.

Conclusions
The preliminary results of this study demonstrate that the majority of clinicians report that they have provided care to young people with severe and enduring presentations. There is a clear need for establishing guidance for clinicians working in pediatric eating disorder settings around models of care focused on quality of life. Engagement with interested parties, including those with lived experience, can clarify the development of terminology and clinical pathways for severe and enduring presentations of pediatric eating disorders.
Challenges and coping mechanisms of parents of children with attention deficit hyperactivity disorder in Addis Ababa, Ethiopia: a qualitative study
Authors: Mesfin Wongelawit , Habtamu Kassahun 
Published: June 2024

AbstractBackgroundAttention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that has manifestations of inattention, hyperactivity, and impulsivity. It affects every facet of a child’s life, including one’s own emotions, family and school life, and social interaction. The few available studies on ADHD conducted in Ethiopia focus on teachers’ awareness and the prevalence of ADHD. None of these studies has taken into account parents of children who have ADHD. The present study, therefore, aimed to find out the challenges and coping mechanisms of parents who have children with ADHD.MethodsA phenomenological qualitative study was conducted to explore the experiences of parents who have children with ADHD. The study was carried out in Addis Ababa, the capital city of Ethiopia. Fourteen parents and two healthcare providers were involved in the study. Participants were selected using a purposive sampling technique. In-depth interviews were conducted with parents of children with ADHD (n = 8) and healthcare providers (n = 2). One focus group discussion (FGD), consisting of six members, was also conducted with parents. A topic guide for conducting the interviews and FGD was developed. Interviews and the FGD were audio-recorded. The data were transcribed verbatim, translated into English, and then analyzed using a thematic analysis approach.ResultsWith regard to challenges of parents of children with ADHD, three themes emerged: social challenges, economic challenges and psychological challenges. Stigma is found to be the most common challenge. Other challenges included worry about the child’s future, lack of social support, strained relationships with others, impact on their job, and marital conflict. Concerning coping mechanisms, two themes emerged: Inward and outward means of coping. The inward means of coping included prayer and developing an optimistic mindset whereas the outward means were family support, healthcare providers’ guidance, and social avoidance.ConclusionsThe study found that parents of children with ADHD experience several aspects of psychological, social, and economic challenges. Support from healthcare professionals, family members, and the community at large is found to be useful for parents to cope with these challenges. Future research should focus on evaluating interventions that would help parents with ADHD cope with the challenges they experience.
Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration
Authors: Nakos Bimpos Modestos , Karali Katerina , Antoniou Christine , Palermos Dionysios , Fouka Maria , Delis Anastasios , Tzieras Iason , Chrousos George Panagiotis , Koutmani Yassemi , Stefanis Leonidas , Polissidis Alexia 
Published: June 2024

AbstractA link between chronic stress and Parkinson’s disease (PD) pathogenesis is emerging. Ample evidence demonstrates that the presynaptic neuronal protein alpha-synuclein (asyn) is closely tied to PD pathogenesis. However, it is not known whether stress system dysfunction is present in PD, if asyn is involved, and if, together, they contribute to neurodegeneration. To address these questions, we assess stress axis function in transgenic rats overexpressing full-length wildtype human asyn (asyn BAC rats) and perform multi-level stress and PD phenotyping following chronic corticosterone administration. Stress signaling, namely corticotropin-releasing factor, glucocorticoid and mineralocorticoid receptor gene expression, is also examined in post-mortem PD patient brains. Overexpression of human wildtype asyn leads to HPA axis dysregulation in rats, while chronic corticosterone administration significantly aggravates nigrostriatal degeneration, serine129 phosphorylated asyn (pS129) expression and neuroinflammation, leading to phenoconversion from a prodromal to an overt motor PD phenotype. Interestingly, chronic corticosterone in asyn BAC rats induces a robust, twofold increase in pS129 expression in the hypothalamus, the master regulator of the stress response, while the hippocampus, both a regulator and a target of the stress response, also demonstrates elevated pS129 asyn levels and altered markers of stress signalling. Finally, defective hippocampal stress signalling is mirrored in human PD brains and correlates with asyn expression levels. Taken together, our results link brain stress system dysregulation with asyn and provide evidence that elevated circulating glucocorticoids can contribute to asyn-induced neurodegeneration, ultimately triggering phenoconversion from prodromal to overt PD.