bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nanoarchitectonics of catalytic tubular nanomotors based on Cu/Fe@SBA-15 for lung cancer treatment
Authors: El-Okaily Mohamed S. , El-Seidy Ahmed M. A. , Ismail Eman H. , Allam Rasha M. , Saeed Ayman A. , Bhaumik Asim , Mostafa Amany A. 
Published: May 2024

AbstractFabrications of nanomotors (NMs) are at the forefront of exploring the true potential of nanotechnology. Tubular nanomotors (TNMs) have been attracting huge interest recently. NMs based on 2D-hexagonal mesoporous silica (SBA-15) have been prepared through the surfactant-assisted sol–gel method. Copper and/or iron oxide nanoparticles have been impregnated in SBA-15 to form catalytic tubular nanomotors. Characterization has been investigated by XPS, XRD, HR-TEM, SEM–EDS, and BET. The electrochemical measurements were used to confirm the motion of the nanomotors. By increasing the loading of metal oxide nanoparticles, the motion decreases; this could be observed from the current loss. The anti-cancer potential of synthesized nanomotors against two cell lines (A549 and H460) of human lung carcinoma has been tested. Among all tested NMs, high-metal oxide-loaded materials containing CuO only as well as CuO and Fe2O3 are potent and significant in apoptotic cell death for lung cancer treatment.
Graphical abstract
The growth and characterization of Au-catalyzed gallium oxide nanowires
Authors: Dorsey Geordan , Moore Antonio , Heffner Christian , Ueda Akira , Mu Richard , Collins W. E. 
Published: May 2024

AbstractGallium oxide is a powerful and versatile wide band gap semiconductor, which has been gaining scientific interest in recent years due to its applications in power electronics. In this work, the growth of β-gallium oxide (Ga2O3) nanowires has been achieved by the vapor–solid–liquid method on silicon wafer, fused quartz, and gallium oxide thin-film substrates. In a chamber purged of ambient atmosphere, pure gallium was heated to produce gallium vapor, which was then oxidized by minute oxygen impurities in the backing gas to form gallium oxide nanowires on a substrate, inside a vertical tube furnace. On the silicon wafer substrates, β-Ga2O3 nanowires were observed to grow in a specific crystallographic direction via transmission electron microscopy. The resulting nanowires were highly faceted and had a unique polyhedral structure on the gold catalyst ‘cap’ of the nanowire. Time of growth and oxygen-level studies were conducted on nanowires grown on various substrates.
Graphical abstract
Acid attack on hydrated cement: effect of organic acids on the degradation process
Authors: Hilbig H. , Gutberlet T. , Beddoe R. E. 
Published: May 2024

AbstractOwing to their ability to form buffer solutions, the attack of organic acids on concrete structural components can be highly aggressive. This work considers the changes in microstructure, chemical and phase composition in hardened Portland cement paste (hcp) exposed to acetic acid/sodium acetate or citric acid/sodium citrate buffer solutions. The degradation products were investigated using 29Si and 27Al NMR spectroscopy with XRD and ICP-OES. Exposure to acetic acid/sodium acetate at pH 3.9 ≤ pH ≤ 5.5 decalcifies hcp to produce aluminosilica gels (0.1 ≤ Al/Si ≤ 0.3) with Si predominately in Q3/Q4 sites and NBO values (non-bridging oxygen per Si atom) 0.6 ≤ NBO ≤ 0.9. Cross-linking processes causing the formation of the gel from C–A–S–H dreierketten incorporate Al, originally in crystalline phases and C–A–S–H phases. Degradation by citric acid/sodium citrate is governed by the precipitation of expansive calcium citrate which continuously removes degraded surface material. Pore-blocking at the degradation front inhibits acid transport deeper into the material. A new mathematical expression is presented which enables the calculation of NBO for aluminosilica gels of known Al/Si ratio from 29Si NMR spectra despite overlapping signals. The expression was verified by a stochastic computer model based on a Si quartz lattice with substituted Al and vacancies. The model simulated the measured 29Si NMR spectra of aluminosilica gels.
Effectiveness and safety profile of fluticasone propionate 0.05% in paediatric dermatoses
Authors: Mohankar Atul Dilip , Sinha Mayank 
Published: May 2024

Background: Topical corticosteroids are effective in the treatment of paediatric dermatoses. However, concerns regarding possible side effects of topical steroids have limited the use of moderate-potency corticosteroids in children. Objective of this study was to evaluate the effectiveness and safety profile of fluticasone propionate 0.05% cream in paediatric dermatoses.
Methods: A total 84 children between 6 months to 12 years of age with moderate to severe dermatoses (< or =30% body surface area) were treated with fluticasone propionate 0.05% cream twice daily for 4 to 6 weeks. Adverse effects of topical steroids were analyzed.
Results: Out of total 84 patients, 46 (54.76%) patients completely cured at 4 weeks and 23 (27.38%) patients at 6 weeks, while remaining 11 (13.10%) patients showed moderate improvement, 4 were lost for follow up after 2 weeks. Only in 2 patients we observed hypopigmentatipon of skin, otherwise in all patients no significant side effect were seen.
Conclusions: Fluticasone propionate 0.05% cream appears to be quite safe for the treatment of moderate to severe dermatoses for up to 4 to 6 weeks in children less than 12 years of age.
Comparing of Metabolic Syndrome Components, Inflammation, Cortisol Level, and Psychological Distress in Obese/Overweight and Normal Weight Women
Authors: Hoseini Golazin , Soltani Esmail , Hejazi Najmeh , Gordali Maedeh , Sohrabi Zahra 
Published: May 2024

Background: High levels of stress in obese people, hypothalamic-pituitary-adrenal (HPA) axis disorder, and social pressures can increase cortisol level and lead to psychological disorders. The aim of this study is to compare psychological distress, biochemical parameters, and metabolic syndrome components between normal-weight and overweight (OW)/obese women. Methods: This was an analytical cross-sectional study conducted on 75 women aged 18 to 60; they were divided into three groups: obese and OW on diet (obese/OW on diet), obese and OW without diet (obese/OW without diet), and normal-weight. The components of metabolic syndrome, serum cortisol, and high sensitive C-reactive protein (hs-CRP) levels were measured. General health questionnaire-28 (GHQ-28) was also completed to assess psychological distress. Result: The results revealed that there was a significant difference between normal weight and the other two groups regarding metabolic syndrome components, which included waist circumference (WC), fasting blood sugar (FBS), systolic blood-pressure (SBP), and hs-CRP (P<0.05). Serum cortisol level was significantly higher in obese/OW on diet compared with the other two groups (P<0.001). Moreover, the total-GHQ score was significantly lower in normal weight compared with the group of obese/OW on diet and the group without diet (P=0.001). Conclusion: Being on a diet may expose a person to stress and increase the serum cortisol level. Elevated psychological distress, metabolic syndrome components, and inflammation were apparent in obese and OW women compared to normal-weight ones.
A multi-center clinical study on the treatment of knee osteoarthritis with Qubi Yangge Decoction combined with three steps and nine methods of whole knee
Authors: Zhang Shuming , Ye Jie , Jin Zhenxiong , Zhou Xiaoning , Xu Jinhai , Mo Wen 
Published: May 2024

Abstract

Background
Knee osteoarthritis(KOA) is the type of osteoarthritis with the highest incidence, the most common clinical, and the greatest damage to individuals and society. The combination of traditional Chinese decoction and manipulation has been proved to be effective in the treatment of KOA. However, no evidence-based medical research has been organized to assess the effectiveness and safety of traditional Chinese medicine(TCM) treatment of KOA.
Methods
In this multicenter randomized positive controlled clinical trial, 144 eligible patients from four clinical trial centers will be randomly divided into a treatment group (Qubi Yangge Decoction combined with three steps and nine methods of whole knee) and a control group (oral western medicine and physiotherapy). Before and after the intervention, the main efficacy indicators included WOMAC osteoarthritis index questionnaire; VAS visual analogue pain score; Sf-36 score of quality of Life Evaluation Scale. The above indexes were recorded once before treatment, 2 weeks, 4 weeks and 12 weeks after treatment. During the treatment period, any signs of acute adverse eventswill be recorded at each visit.
Discussion
Although Qubi Yangge Decoction combined with three steps and nine methods of whole knee in treating of KOA has been used in China for many years, there is no consensus on its effectiveness. This experiment will provide convincing evidence of the efficacy of Qubi Yangge Decoction combined with three steps and nine methods of whole knee in the treatment of KOA.
Trial registration:
The clinical trial has been registered in the Chinese Clinical Trial Database (registration number ChiCTR2000036077).
The Impact of Histone Post-translational Modifications H3K9me on Same Gene Mutation Rate in Fission Yeast
Authors: Abdalla Ola , Walker Cameron 
Published: May 2024

Abstract

Mutations are the driving force behind genetic variation, fueling both the oncogenesis and evolution of species. The mutation rate varies across the genome, potentially in response to chromatin organization by histone modifications and other factors. However, the exact relationship between the two is yet to be fully understood and requires further investigation. One modification involves the methylation of histone H3 at lysine 9, which creates heterochromatin and represses transcription in euchromatin to maintain genome stability for organism survival. This study aimed to determine the effect of H3K9 methylation alone, without other histone markers, on the mutation rate in fission yeast using fluctuation assays and statistical analysis. Our groundbreaking method has been proven to accurately estimate mutation rates of a single gene under two different conditions in a single experiment using one isogenic clone. Our research results demonstrate that the H3K9me markers increase the phenotypic mutation rate of the same gene. For prospective researchers, this study presents an innovative experimental approach that ensures unparalleled accuracy in gene analysis for genetics applications and epigenetic therapy.
Femoral Neck Shaft Angle Measurement for Differentiating Femoral Head
Stress Fracture from Avascular Necrosis
Authors: Kim Dong Kyu , Lee Kyu-Chong , Ahn Kyung-Sik , Kang Chang Ho 
Published: May 2024

Objective:
The study aimed to evaluate whether the measurement of Femoral Neck Shaft Angle (FNSA) can be helpful in differentiating femoral head Stress
Fracture (SF) from Avascular Necrosis (AVN).

Methods:
From September 2019 to April 2022, sixty-four patients [median age 32.0 years, interquartile range (IQR) 23.0–39.0 years] who underwent both
hip radiograph and Magnetic Resonance Imaging (MRI) and diagnosed as femoral head SF or AVN were included in our retrospective study.
Patients were divided into as having either femoral head SF (n = 34) or AVN (n = 30). The FNSA was measured in anteroposterior hip
radiography. Continuous values were compared using the Mann-Whitney U test. The assessment of the predictive value of FNSA for femoral head
SF was performed by Receiver Operating Characteristic (ROC) analysis.

Results:
The FNSA was significantly higher in patients with SF (median 133.5°, IQR 128.0–136.7°) than those with AVN (median 127.5°, IQR
124.0–132.0°) (p = 0.001). In addition, the FNSA was significantly higher in SF femurs (median 134.8°, IQR 129.2–137.4°) than in contralateral
normal femurs (median 127.1°, IQR 124.3–132.5°) in patients with unilateral femoral head SF (n = 30) (p < 0.001). In ROC analysis, the
sensitivity, specificity, and Area Under the Curve (AUC) for predicting the femoral head SF were 77.3%, 63.3%, and 0.785 (95% confidence
interval: 0.666–0.905), respectively, at a cutoff of 130.2°.

Conclusion:
Increased FNSA was associated with femoral head SF; thus, measurement of FNSA could be helpful for differentiating femoral head SF from
AVN.
MR Imaging of Typical Ovarian Hemangioma: A Case Report
Authors: Yu Xiaoli , Zheng Qingqing , Ai Min , Zhang Hanghang , Li Chuanming , Feng Junbang , Zhou Jing 
Published: May 2024

Background:
Ovarian hemangioma is an extremely rare tumor with atypical clinical manifestations, often discovered incidentally during autopsy or surgery.
Approximately 60 cases have been reported in the past, but no more than 10 cases have been investigated by MRI and ultrasound (US).

Case Presentation:
ln this paper, we reported a 51-year-old female patient with Ovarian Hemangioma who had no symptoms of abdominal pain, abnormal vaginal
bleeding or discharge, or any other discomfort. Laboratory tests revealed an elevated serum carbohydrate antigen (CA125) of 48.99U/ml (reference
range: 0-35U/ml). Multiparametric 3.0T magnetic resonance imaging (MRI) showed a cystic solid mass with a clear boundary and regular shape in
the left ovarian area and minimal ascites in the abdominal cavity. The histological examination of the mass confirmed an ovarian hemangioma.

Conclusion:
The MRI findings of ovarian hemangiomas are highly similar to those observed in hepatic hemangiomas, emphasizing the distinctive radiological
characteristics specific to this condition in the ovary. This paper presents an overview of the typical MRI findings associated with ovarian
hemangioma, which holds great importance for accurate diagnosis and effective treatment.
Evaluating Ocular Blood Flow in Diabetic Macular Edema using Three-dimensional
Pseudocontinuous Arterial Spin Labeling
Authors: Sun Jiao , Wang Huihui , Wang Yan-ling 
Published: May 2024

Background:
Alterations in ocular blood flow play an important role in the pathogenesis of diabetic macular edema; however, this remains unclear.

Objectives:
This study aimed to investigate ocular blood flow in eyes with or without diabetic macular edema using arterial spin labeling.

Methods:
This cross-sectional study included 118 eyes of 65 patients with diabetic retinopathy analyzed between November 2018 and December 2019. We
included a total of 53 eyes without diabetic macular edema (mean [SD] age, 57.83 [7.23] years; 29 men [54.7%]) and 65 eyes with diabetic
macular edema (mean [SD] age, 60.11 [7.63] years; 38 men [58.5%]). Using a 3.0-T magnetic resonance imaging, participants were imaged with
arterial spin labeling with multiple post-labeling delays.

Results:
The mean ocular blood flow at post-labeling delays of 1.5 and 2.5 s was significantly lower in eyes with diabetic macular edema among patients
with diabetic retinopathy compared with the remaining subgroups (P=0.022 and P <0.001, respectively). The mean ocular blood flow exhibited a
significant decrease in eyes with diabetic macular edema when the post-labeling delay was set at 2.5 s in the nonproliferative and proliferative
diabetic retinopathy groups, compared with the remaining subgroups (P=0.005 and P=0.002, respectively). The cutoff points of ocular blood flow
at post-labeling delays of 1.5 s and 2.5 s were 9.40 and 11.10 mL/100 g/min, respectively.

Conclusion:
Three-dimensional pseudocontinuous arterial spin labeling can identify differences in the ocular blood flow of patients with diabetic eyes with and
without diabetic macular edema.
Експресія нейрон-специфічної єнолази в сітківці та вплив на неї агоніста бензодіазепінових рецепторів карбацетаму при експериментальній діабетичній ретинопатії
Authors: Zyablitzev S.V. , Zhupan D.B. 
Published: May 2024

Актуальність. На сьогодні визнано, що в патогенезі діабетичної ретинопатії (ДР) поряд з розвитком судинних порушень у сітківці незалежно розвивається дисфункція нейронів і процеси нейродегенерації. Метою наших досліджень було визначення експресії нейрон-специфічної єнолази (NSE) у сітківці на початкових стадіях розвитку експериментальної ДР і впливу на неї агоніста бензодіазепінових рецепторів карбацетаму. Матеріали та методи. У 45 трьохмісячних щурів-самців лінії Wistar моделювали ДР шляхом одноразового введення стрептозотоцину (50 мг/кг; Sigma-Aldrich, Co, China). Щурів було розподілено на 3 групи: контрольна, з уведенням інсуліну (30 ОД; Novo Nordisk A/S, Denmark) і з уведенням інсуліну й карбацетаму (5 мг/кг). Імуногістохімічно в сітківці виявляли NSE (ThermoFisher Scietific, USA). Результати. У сітківці щурів з експериментальною ДР NSE-позитивне забарвлення мали гангліонарні клітини, нейрони внутрішнього і зовнішнього ядерних шарів і внутрішній сегмент фоторецепторів. Інтенсивність забарвлення в контрольній групі збільшувалася до 14-ї доби, після чого лишалася на низькому рівні. У внутрішньому ядерному шарі спостерігалося фонове забарвлення, на тлі якого візуалізувалися численні нервові волокна. Через 2 місяці в контрольній групі загальна інтенсивність забарвлення в нейронах сітківки була слабкою, NSE-позитивні клітини групувалися навколо мікроаневризм, які на цей час утворювалися по внутрішній поверхні сітківки. У зовнішньому ядерному шарі формувалися численні клітинні фіброзні проліферати. Застосування інсуліну сприяло збереженню NSE-позитивно забарвлених клітин у шарах сітківки при зменшенні інтенсивності фонового забарвлення. Застосування інсуліну з карбацетамом посилювало цю тенденцію: NSE-позитивне забарвлення виявлялося в гангліонарних клітинах, клітинах внутрішнього ядерного шару і внутрішньому сегменті фоторецепторів. При цьому утворення мікроаневризм і клітинних проліфератів не спостерігалося. Висновки. У даному дослідженні показаний ефект карбацетаму щодо запобігання розвитку процесів нейродегенерації та збереження NSE-позитивних нейронів сітківки при ДР.
Elimination study of intact lipid nanocapsules after intravenous rat administration
Authors: Lebreton Vincent , Legeay Samuel , Rapenne Clara , Saulnier Patrick , Lagarce Frédéric 
Published: May 2024

Aim: The present study investigated renal elimination after intravenous administration of four different formulations of lipid nanocapsules (LNCs) containing dyes adapted to Förster resonance energy transfer (FRET-LNCs). Materials & methods: FRET-LNCs of 85 or 50 nm with or without a pegylated surface were injected and collected in the blood or urine of rats at different time points. Quantitative analysis was performed to measure intact FRET-LNCs. Results & conclusion: No intact LNCs were found in urine (0 particles/ml) for all formulations. The 50-nm pegylated LNCs were eliminated faster from the blood, whereas 85-nm pegylated LNCS were eliminated slower than nonpegylated LNCs. Elimination of FRET-LNCs was mainly due to liver tissue interaction and not renal elimination.
A CLAUSE COMPLEX ANALYSIS OF PROBLEM STATEMENT SECTIONS IN MPHIL THESES ACROSS THREE DISCIPLINES IN A GHANAIAN UNIVERSITY
Authors: Abedu Lucy Amoah , Afful Joseph Benjamin Archibald , Insaidoo Harry Ato 
Published: May 2024

Academic writing is considered persuasive (Hyland 2008) and as post-graduate-students negotiate their entry into the research community, they are expected to build a formidable argument to create a research space for themselves in their research problem statements. As such, how they build logical connections of ideas in their problem statements is key, varying from one discipline to the other. This study explores the Problem Statement sections of MPhil theses, using Halliday and Matthiessen’s (2004/2014) notion of clause complexing in Systemic Functional Linguistics (SFL). Specifically, the study focused on the tactic and the logico-semantic relations of the Problem Statements sections of three disciplines: Mathematics, Nursing, and English Language in the University of Cape Coast, Ghana. The findings reveal that regarding the basic clause complex structure of the three disciplines, English Language uses a lot of clause complexes compared to the other disciplines. Also, all three disciplines use considerable hypotactic relations and hypotactic projection of locution instead of idea since in the problem statements, writers report what others have said and not their own thoughts. In terms of relations of expansion, there are variations in the three disciplines, with English language favoring elaboration whilst Mathematics favor extension and enhancement. The use of expansion relations for Nursing is closer to that of English language. It is suggested that clause complexing is not only determined by genre and mode but also conventions of academic discipline. The findings have implication for theory and disciplinarity in academic writing.
Inhibition of some multidrug-resistant bacteria using prepared essential oil Nanoemulsion formulas and their mode of action
Authors: Amasha Reda H 
Published: May 2024

Objective: The use of essential oils for the preparation of different nanoemulsions (NEa, NEb and NEc) and detect their biological activities.
Methods: Nanoemulsiona were prepared by mixing the essential oil (10 %) of Coriandrum seed of Coriandrum sativum, Ginger roots of Zingiber officinale, or Achillea leaves of Achillea clavennae), sterile water, and surfactants (Brij 30, Span 20, Triton X-100, Tween 60) in addition to the 0.1M Tris-HCl buffer (pH 7.22). The three prepared nanoemulsions were examined and characterized. Their antibacterial activities were examined against some multidrug-resistant Gram-positive and negative bacteria.
Results: The maximum activity was recorded By NEb against Serratia marcescens, Staphylococcus aurous, Micrococcus luteus, Enterococcus faecalis, Streptococcus pyogenes, and Staphylococcus saprophyticus while lower activity was obtained against Klebsiella pneumonia and Escherichia coli. The minimum inhibitory concentrations (MICs) of the NEb ranged from 40-60 µl/ml of the nutrient broth. NEb affects the cell counts and morphology of S. marcescens and destroys the bacterial cells by reducing cell respiration and enhancing the cell permeability and leakage of protein, DNA, and potassium of the bacterial cell membrane. NEb recorded no toxicity against Artimia salina and HaCaT cell line. It decreases biofilm formation by 51%, bacterial infection, and cell attachment.
Conclusion: This study suggests that NEs have great antibacterial activity against some human pathogens and process different modes of action, thus they can be used effectively to treat different bacterial infections.