bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of two assays for detection of antibodies against canine parvovirus and canine distemper virus in dogs admitted to a Florida animal shelter
Authors: Gray Lauren K. , Crawford P. Cynda , Levy Julie K. , Dubovi Edward J. 
Published: April 2012

Abstract
Objective—To compare 2 assays for use in the identification of dogs with a protective antibody titer (PAT) against canine parvovirus (CPV) and canine distemper virus (CDV).
Design—Prospective cross-sectional study.
Animals—431 dogs admitted to a municipal animal shelter in north central Florida.
Procedures—Blood samples were collected from dogs on the day of admission to the shelter. Serum was obtained, criterion-referenced assays were used to identify dogs that had PATs against CPV (titers ≥ 80; hemagglutination inhibition assay) and CDV (titers ≥ 32; virus neutralization assay), and results were compared with results of a semiquantitative ELISA and an immunofluorescence assay (IFA).
Results—For correct identification of dogs that had PATs against viruses, the ELISA had significantly higher specificity for CPV (98%) and CDV (95%) than did the IFA (82% and 70%, respectively) and had significantly lower sensitivity for CDV (88%) than did the IFA (97%); the sensitivity for CPV was similar (ELISA, 98%; IFA, 97%). Overall diagnostic accuracy was significantly greater with the ELISA than with the IFA. Predictive value of a positive result for PATs was significantly higher with the ELISA for CPV (99%) and CDV (93%) than with the IFA (92% and 71 %, respectively).
Conclusions and Clinical Relevance—The ELISA had fewer false-positive results than did the IFA and could be performed on-site in shelters in < 1 hour. Accuracy and practicality of the ELISA may be useful for identifying the infection risk of dogs exposed during outbreaks attributable to CPV and CDV infections in shelters.
Relationship between paradoxical breathing and pleural diseases in dyspneic dogs and cats: 389 cases (2001–2009)
Authors: Le Boedec Kevin , Arnaud Catherine , Chetboul Valérie , Trehiou-Sechi Emilie , Pouchelon Jean-Louis , Gouni Vassiliki , Reynolds Brice S. 
Published: April 2012

Abstract
Objective—To determine the strength of the relationship between paradoxical breathing (PB) and spontaneous pleural diseases in dyspneic dogs and cats.
Design—Cross-sectional study.
Animals—Dogs (n = 195) and cats (194) with a recorded diagnosis of dyspnea examined at the National Veterinary Schools of Alfort and Toulouse (France) between January 2001 and October 2009.
Procedures—Dogs and cats were divided into 2 groups according to the presence or absence of PB. Stratified analysis by species was performed. Signalment of affected animals and occurrence of PB were recorded. The relationship between PB and pleural diseases among dyspneic dogs and cats was analyzed.
Results—A strong relationship between PB and pleural diseases was highlighted in multivariate analysis (dogs, OR = 12.6 and 95% confidence interval = 4.6 to 31.2; cats, OR = 14.1 and 95% confidence interval = 6.0 to 33.5). Paradoxical breathing prevalence among dyspneic dogs and cats was 27% and 64%, respectively. Occurrence of pleural diseases in dyspneic animals with and without PB was 49% and 9% in dogs and 66% and 13% in cats, respectively. The sensitivity and specificity of PB as a predictor of pleural diseases were 0.67 and 0.83 in dyspneic dogs and 0.90 and 0.58 in dyspneic cats, respectively. The positive and negative predictive values of PB were 0.49 and 0.91 in dyspneic dogs and 0.66 and 0.87 in dyspneic cats, respectively. Age, sex, feline breeds, and canine morphotypes in patients with PB were not significantly different from those of other dyspneic animals.
Conclusions and Clinical Relevance—PB was strongly associated with pleural diseases in dyspneic dogs and cats. The presence of this clinical sign should prompt small animal practitioners to implement appropriate emergency procedures and guide their diagnostic strategy.
Comparison of radiography, nuclear scintigraphy, and magnetic resonance imaging for detection of specific conditions of the distal tarsal bones of horses: 20 cases (2006–2010)
Authors: Daniel Alexander J. , Judy Carter E. , Rick Mark C. , Saveraid Travis C. , Herthel Douglas J. 
Published: April 2012

Abstract
Objective—To describe pathological findings identified with MRI in the distal tarsal bones of horses with unilateral hind limb lameness attributable to tarsal pain and to compare the usefulness of MRI with that of radiography and nuclear scintigraphy in evaluation of this region.
Design—Retrospective case series.
Animals—20 lame horses.
Procedures—In all horses, MRI, radiography (4 standard projections), and nuclear scintigraphy of the tarsus had been performed. Horses were excluded if the results of all 3 imaging modalities were not available or if lameness was detected in more than 1 limb. Pathological changes identified with MRI were cross-referenced with the findings determined with other imaging modalities.
Results—Compared with MRI findings, the following lesions were identified with radiography: medullary and subchondral bone sclerosis in 9 of 16 horses, pathological changes related to osseous hyperintensity in 0 of 10 horses, and osteoarthritis in 5 of 8 horses. Standard radiographic projections did not aid in the identification of fracture of the distal tarsal bones (3 horses). Location of increased radiopharmaceutical uptake with nuclear scintigraphy corresponded with the location of pathological changes detected with MRI in all horses. The intensity of the radiopharmaceutical uptake on nuclear scintigraphic images did not correspond with the severity of the pathological changes identified with MRI.
Conclusions and Clinical Relevance—Radiography was unreliable for the detection of pathological changes related to osseous hyperintensity identified with MRI, fracture, and subchondral bone sclerosis in the equine tarsus. Nuclear scintigraphy was effective in localizing pathological changes, but MRI provided superior anatomic detail.
The analysis of heavy metals content in herbal infusions
Authors: Suchacz Bogdan , Wesolowski Marek 
Published: April 2012

Abstract
The content of 8 heavy metals (Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn) was evaluated in infusions prepared from 13 different herbal compositions commercially available in drug or herbal stores. The mixtures were produced by a Polish manufacturer “Herbapol”. The concentration of heavy metals was determined using flame atomic absorption spectrometry (FAAS). In the herbal infusions Mn was found in the highest concentration varying from 3.03 to 129.01 mg/kg. The element of the lowest content was Cd in the range of 0.024–0.153 mg/kg. According to interquartile ranges the concentrations of studied heavy metals in infusions decreased in the following descending order: Mn>Fe>Zn>Cu>Ni>Cr>Pb>Cd. Cluster analysis allowed for the division of herbal infusions into groups described by comparable levels of heavy metals. In water extracts made from Urosan, Nervosan, Infektoten and Cholagoga, distinctive levels of Mn, Fe and Cr were determined. According to WHO regulations, the concentrations of the elements did not exceed the allowable limits.
A hydro power system operation using Genetic Algorithms and mixed-integer nonlinear programming
Authors: Šulek P. 
Published: April 2012

A hydro power system operation using Genetic Algorithms and mixed-integer nonlinear programmingThis paper proposes a new hybrid optimization method for solving a hydrothermal coordination problem. In general, the problem is decomposed into smaller hydro and thermal sub-problems which are solved separately. The hydro sub-problem is solved by the peak shaving method using the proposed hybrid optimization method. It combines genetic algorithms with the traditional numerical optimization method. The hybrid method has been applied to a real hydrothermal system, i.e., the Slovak power system. The results have proved the efficiency of the proposed method.
Characteristics of asphalt mixes with FT additive
Authors: Štefunková S. 
Published: April 2012

Characteristics of asphalt mixes with FT additiveThis article is focused on low-temperature asphalt mixture technologies using FT additive and RAP. The modern production and use of asphalt mixture technologies with reduced temperatures has many advantages. These advantages mainly help to save energy and the environment. Lower temperatures enable a reduction in energy consumption, a more acceptable working environment for workers, a reduction in negative environmental effects, such as greenhouse gas emissions, and an improvement in the workability of mixtures and a prolongation of their duration. This technology is currently becoming popular in many countries.
Lumbar Computerized Adaptive Test and Modified Oswestry Low Back Pain Disability Questionnaire: Relative Validity and Important Change
Authors: Hart Dennis L. , Stratford Paul W. , Werneke Mark W. , Deutscher Daniel , Wang Ying-Chih 
Published: April 2012

Study Design Retrospective analysis of longitudinal, observational cohort data. Objectives To compare discriminating ability and minimal clinically important improvement (MCII) calculated using functional status (FS) measures estimated from the lumbar computerized adaptive test (LCAT) and Modified Oswestry Low Back Pain Disability Questionnaire (ODQ). Background The LCAT and ODQ are commonly used to estimate FS in patients seeking outpatient therapy but have not been compared directly. Methods Data from 8198 adult patients who completed the LCAT and ODQ at intake were analyzed, 3379 (41%) of whom completed both surveys at discharge. Global ratings of change data were available for 980 patients. Discriminating ability of FS estimates from the LCAT and ODQ was estimated using relative validity, calculated by dividing F values from LCAT and ODQ analyses of covariance for important risk-adjustment variables. MCII was estimated using receiver-operating-characteristic analyses by quartiles of intake FS values, and areas under the curves were compared. Results Relative validity ratios favored the LCAT for age (3.7; 95% confidence interval [CI]: 2.0, 8.9), acuity (1.3; 95% CI: 1.1, 1.6), comorbidities (1.8; 95% CI: 1.3, 2.6), and surgical history (1.8; 95% CI: 1.2, 2.9). MCII cut scores per quartile favored the LCAT. Receiver-operating-characteristic areas under the curves were not different. Conclusion FS measures estimated by both questionnaires had similar psychometric characteristics. The LCAT FS estimates tended to be more discriminating than ODQ FS estimates. MCII cut scores by quartile of intake FS favored the LCAT. Given the need to be efficient and precise in estimating measures of FS, particularly in older patients, results favor the LCAT in busy, automated outpatient therapy clinics, which are increasingly serving an aging population. J Orthop Sports Phys Ther 2012;42(6):541–551, Epub 19 April 2012. doi:10.2519/jospt.2012.3942
CD4+ T cell activation promotes the differential release of distinct populations of nanosized vesicles
Authors: van der Vlist Els J. , Arkesteijn Ger J.A. , van de Lest Chris H.A. , Stoorvogel Willem , Nolte‐'t Hoen Esther N.M. , Wauben Marca H.M. 
Published: April 2012

Many cell types release nanosized vesicles derived from endosomal compartments (exosomes) or the plasma membrane. Vesicles actively released by CD4+ T cells have immune‐modulatory characteristics. Using our recently developed high‐resolution flow cytometry‐based method for the analysis of individual nanosized vesicles, we here investigated how T cell receptor (TCR)‐triggering and co‐stimulatory signals influence the quantity and characteristics of nanosized vesicles released by CD4+ T cells. We found that the number of released nanosized vesicles within the buoyant density range characteristic for exosomes (1.10–1.19 g/ml) was increased by TCR‐triggering and that additional co‐stimulatory signals had a potentiating effect on vesicle release. However, the increase in the number of released vesicles varied substantially between density fractions within the 1.10–1.19 g/ml range and was highest for the vesicle populations in 1.14 and 1.17 g/ml fractions. Heterogeneity was also observed within the individual density fractions. Based on lipid bilayer fluorescent labelling intensity and light scattering, 3 distinct vesicle subpopulations were identified. One vesicle subpopulation increased significantly more upon T cell activation than the other subpopulations, and this was dependent on high levels of co‐stimulation. These data show that T cells release a heterogeneous population of nanosized vesicles and indicate that T cells differentially regulate the release of distinct vesicle subpopulations depending on their activation status.
D282, a Non-Nucleoside Inhibitor of Influenza Virus Infection that Interferes with de novo Pyrimidine Biosynthesis
Authors: Smee Donald F , Hurst Brett L , Day Craig W 
Published: April 2012

Background: The discovery of novel influenza virus inhibitors remains an important priority in light of the emergence of drug-resistant viruses. Toward this end, a library of over 6,000 compounds was tested for antiviral activity. Methods: Strains of influenza virus were evaluated by cytopathic effect (CPE) inhibition and virus yield reduction assays. Intracellular nucleoside triphosphate pools were analysed by strong anion exchange HPLC. Dihydroorotate dehydrogenase inhibition assays were conducted. Influenza virus-infected mice were treated for 5 days with D282. Results: A non-nucleoside, 4-[(4-butylphenyl)amino]-2-methylene-4-oxo-butanoic acid (D282), was discovered that inhibited influenza A and B virus CPE by 50% at 6–31 μM (giving selectivity indices of >13 to >67, based on cytotoxicity of >400 μM in stationary cell cultures). Ribavirin (positive control) was active at 14–44 μM (yielding selectivity indices of >9 to >29, with >400 μM toxicity). D282 and ribavirin inhibited virus yield by 90% at 9.5 ±3.3 and 10.8 ±3.2 μM, respectively. The antiviral activity of D282 in vitro was reversed by addition of uridine, cytidine and orotic acid. D282 exhibited an uncompetitive inhibition of mouse liver dihydroorotate dehydrogenase (inhibitor constant [Ki] of 2.3 ±0.9 μM, Michaelis constant [Km] of 150 ±16 μM). Because cellular pyrimidine biosynthesis was inhibited, D282-treated cells had decreased uridine triphosphate and cytidine triphosphate levels. D282 (≤100 mg/kg/day) failed to prevent death of mice infected with influenza. Conclusions: D282 was active against influenza A and B viruses by inhibiting de novo pyrimidine biosynthesis. Although effective in vitro, the compound, like others in its class, was devoid of antiviral activity in infected mice.
Sur l'intériorité, la profondeur et l'intimité subjectives : un état des lieux
Authors: Nordmann Jean-François 
Published: April 2012

Résumé Mettant en cause les lacunes et les résistances qu’on trouve dans les sciences humaines comme dans la philosophie relativement aux notions d’intériorité, de profondeur et d’intimité subjectives, ce travail entreprend d’indiquer une voie possible d’habilitation phénoménologique de ces notions qui conduit en particulier à la reconnaissance et à l’exploration du champ d’affectivité intérieure et profonde dont relèvent les formations du désir et de l’intimité. De là, il peut plus spécifiquement interroger et mettre en question le lien communément établi entre l’intime et le familial, et en venir à considérer le sens contradictoire des évolutions actuelles, à la fois libératrices et qui perpétuent d’aliénations, dans le domaine des relations « privées » affectives, sexuelles et familiales.
Aux sources de l'intimité
Authors: Darchis Élisabeth 
Published: April 2012

Résumé Le concept d’intimité recouvre plusieurs aspects : l’intimité première ou intimité primaire qui décrit l’expérience de l’intimité initiale dans l’indifférenciation mère-bébé en périnatalité. Ce bain d’intimité dont bénéficie le nourrisson a été préparé par les futurs parents dès la grossesse lors de leur voyage psychique à la recherche de l’intimité familiale d’autrefois. Progressivement l’enfant s’approprie cette première ambiance familiale de la petite enfance, pour pouvoir vivre psychiquement en dehors de l’objet. Ce stade que l’on pourrait désigner comme l’intimité secondaire ou différenciée, va de pair avec l’autonomie et la construction du Moi. Mais c’est l’empreinte de la première intimité groupale en soi, qui permet la rencontre en profondeur avec l’autre dans l’intimité relationnelle partagée. Quand l’accès à l’autonomie des membres de la famille est entravé, nous observons alors des fonctionnements familiaux prolongeant l’indifférenciation de la première intimité dans ce que l’on pourrait appeler une intimité pathologique confuse.
Les vecteurs corporels du lien filial
Authors: Delaisi de Parseval Geneviève 
Published: April 2012

Résumé Les paramètres corporels et biologiques du lien filial ont été bouleversés depuis l’apparition des techniques d’assistance médicale à la procréation. Devenus autonomes, manipulables et affranchis parfois du temps et même de la différence des sexes, ces signifiants de la filiation donnent lieu à des aménagements psychodynamiques variés dont certains sont examinés ici. L’ébauche d’un roman familial non traditionnel ?
L'électeur incertain
Authors: Muxel Anne 
Published: April 2012

Résumé Les nouvelles générations d’électeurs, libérées des affiliations traditionnelles, opèrent leur choix de plus en plus tardivement. Elles revendiquent aussi le droit de ne pas voter. La légitimité acquise dans les urnes s’en trouve-t-elle affaiblie ? Non, selon Anne Muxel, qui voit le vote se réarticuler à d’autres formes d’expression politique.
PFA(S)[S]: More Mutually Consistent Topological Consequences of PFA and V = L
Authors: Tall Franklin D. 
Published: April 2012

Abstract Extending the work of Larson and Todorcevic, we show that there is a model of set theory in which normal spaces are collectionwise Hausdorff if they are either first countable or locally compact, and yet there are no first countable L-spaces or compact S-spaces. The model is one of the form PFA(S)[S], where S is a coherent Souslin tree.
Analysis of the Brylinski-Kostant Model for Spherical Minimal Representations
Authors: Achab Dehbia , Faraut Jacques 
Published: April 2012

AbstractWe revisit with another view point the construction by R. Brylinski and B. Kostant of minimal representations of simple Lie groups. We start froma pair (V,Q), whereVis a complex vector space andQa homogeneous polynomial of degree 4 onV. The manifoldis an orbit of a covering of Conf(V,Q), the conformal group of the pair (V,Q), in a finite dimensional representation space. By a generalized Kantor-Koecher-Tits construction we obtain a complex simple Lie algebra 𝔤, and furthermore a real form 𝔤ℝ. The connected and simply connected Lie groupGℝ with Lie(Gℝ) = 𝔤ℝ acts unitarily on a Hilbert space of holomorphic functions defined on the manifold.
A Generalization of a Theorem of Boyd and Lawton
Authors: Issa Zahraa , Lalín Matilde 
Published: April 2012

Abstract.The Mahler measure of a nonzero n-variable polynomial P is the integral of log |P| on the unit n-torus. A result of Boyd and Lawton says that the Mahler measure of a multivariate polynomial is the limit of Mahler measures of univariate polynomials. We prove the analogous result for different extensions of Mahler measure such as generalized Mahler measure (integrating the maximum of log |P| for possibly different P’s), multiple Mahler measure (involving products of log |P| for possibly different P’s), and higher Mahler measure (involving logk |P|).
The use of a supplemental sulcus fixated IOL (HumanOptics Add-On IOL) to correct pseudophakic refractive errors
Authors: Basarir Berna , Kaya Vedat , Altan Cigdem , Karakus Sezen , Pinarci Eylem Y. , Demirok Ahmet 
Published: April 2012

Purpose. To evaluate the safety and efficacy of piggybacking with the HumanOptics Add-On intraocular lens (IOL) to correct pseudophakic refractive errors. Materials and Methods. Ten eyes of 10 patients with pseudophakic refractive errors were included in this study. All patients were targeted for a range of refraction −0.50 to +0.50 D. Uncorrected and corrected distance visual acuities (UDVA and CDVA, respectively), endothelial cell count (ECC), anterior chamber depth (ACD), the distance between intraocular lenses, and contrast sensitivity measurements under mesopic, scotopic, and scotopic with glare conditions were evaluated preoperatively and postoperatively. Results. The mean age of the patients was 54±27 years (range 4-78). Mean follow-up time was 10.5±1.36 months (range 6-15 months). Mean diopters of implanted Add-On IOLs were −1.4±6.9 (range −12 to +9 D). Mean preoperative and postoperative UDVA was 0.133±0.12 and 0.73±0.27, respectively (p=0.0001); mean preoperative and postoperative CDVA were 0.77±0.26 and 0.79±0.27, respectively (p=0.066). Mean preoperative and postoperative ACD were 3.87±0.91 mm vs 3.58±1.05 mm, respectively (p=0.343); mean inter-IOL distance was 0.53±0.08 mm. Mean preoperative and postoperative ECC were 2455±302 and 2426±294, respectively (p=0.55). All patients were within the targeted refractive range of −0.50 D to +0.50 D. No complications were observed during the operations or postoperative follow-up period. Conclusions Piggybacking with the Add-On IOL is a safe, efficient, and reliable technique to correct pseudophakic refractive errors.