bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategic planning in conditions of uncertainty: Adaptivity for sustainability
Authors: Якобсон Л.И. 
Published: April 2024

При разработке стратегических планов государства и бизнеса сегодня приходится учитывать глубокую неопределенность будущих состояний природной и общественной среды. В бизнесе постепенно формируются подходы к решению этой задачи и переосмысливаются привычные представления об управлении рисками. Та же задача, еще более сложная применительно к стратегическому планированию на уровне государств, становится весьма настоятельной, но пока решается менее успешно. Бесперспективны попытки найти ее решение на основе опыта советского планирования и в целом на базе планирования как детальных, так и агрегированных показателей производства конкретной продукции (outputs). Более адекватны подходы, ориентированные на индикаторы конечных результатов (outcomes) при условии придания приоритетности не многочисленным количественно определенным заданиям, а устойчивости направлений развития и оптимальных способов действий. Целесообразно, с одной стороны, избегать включения в стратегические планы верхнего уровня того, что может потребовать корректировок ради реакций на новые вызовы и возможности, а с другой — предусматривать в этих планах стратегии реагирования на них, включающие условия и правила корректировок планов иных уровней. Предлагается один из инструментов управления рисками в условиях неопределенности под названием «лестницы устойчивости».
When designing both governmental and business strategic plans nowadays, an overwhelming uncertainty about the future state of natural and social environment needs to be considered. Businesses are gradually shaping approaches to solve this problem and revising the known ideas of risk management. At the government level, however, the same problem, which becomes even more challenging, urgent and demanding, is still being solved less successfully. Any attempts to find the solution, mostly drawing on the Soviet planning experience, and generally based on the planning of both detailed and aggregate output indicators for specific products are futile. Approaches targeting outcomes are more adequate, provided that priority is given to the sustainability of the plans rather than to the number of quantitatively defined targets. It is expedient, on the one hand, to avoid including in the strategic plans a higher level of what may require adjustments for the sake of responding to new challenges and opportunities. On the other hand, it is advisable to introduce response strategies in these plans, including conditions and rules for the adjustment of plans at the other levels. This paper proposes one of the instruments for risk management in conditions of uncertainty called “a ladder of sustainability”.
Prospects for the use of probiotic microorganisms in the production of fermented buckwheat-based products
Authors: Gelazov R.  Kh. , Iakovchenko N. V. , Bayazitov K. R. , Shiriaev V. A. 
Published: April 2024

Relevance. The market segment for products based on plant-based ingredients continues to gain momentum. Protecting health and reducing the environmental burden are the most important driving forces for consumers to buy plant-based products. About 1% of the world’s population suffers from diagnosed celiac disease. Around 13% of the population exhibits symptoms of non-celiac gluten sensitivity. Thus, the production of gluten-free food products, including fermented ones, is becoming increasingly important.Methods. The technological parameters for producing buckwheat dispersion and its quality indicators were assessed. The analysis of the process of acid accumulation during fermentation by microorganisms Lactobacillus, Bifidobacterium, Propionibacterium, and Streptococcus was carried out. Data on the dynamics of microbial biomass accumulation during fermentation were obtained, and the influence of selected starter cultures on the antioxidant properties of fermented dispersions during storage was studied. The impact of chosen strains on organoleptic characteristics was determined, and the dependence of the viscosity of fermented samples on the shear rate was studied.Results. Buckwheat dispersion is a suitable medium for the production of fermented drinks. The duration of fermentation ranged from 5 to 9 hours. The most intense acid accumulation process is observed when S. thermophilus is used for 5 hours. The maximum increase in biomass is achieved with L. bulgaricus, L. acidophilus AT-41, and B. bifidum. Probiotic microorganisms provide stable levels of antioxidant activity during storage. The samples fermented with S. thermophilus, B. bifidum, P. shermanii KM-186, and L. bulgaricus were the most viscous. The most outstanding organoleptic preference was given to samples with L. acidophilus 57S, S. thermophilus, and L. bulgaricus.
The mechanism of interaction of the animal›s body with the microbiota of the gastrointestinal tract (review)
Authors: Grechkina V. V. , Sheida E. V. , Kvan O. V. 
Published: April 2024

The intestines of animals are a complex ecosystem consisting of a microbiome, host cells, and nutrients. There are about 100 trillion bacteria in the intestinal tract that form the intestinal microbiota. They are taxonomically classified by genus, family, order, and type. The intestinal microflora mainly consists of six types: Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Fusobacteria and Verrucomicrobia. Bacterioidetes and firmicutes occupy a dominant position in the intestinal tract of animals and play a key role in the nutrient absorption system and help strengthen the intestinal barrier. The composition of the microbial community ecosystem is dynamic, and its composition depends on many factors including genes, medications, and feeding.The purpose of this review is to analyze the microbiome of the gastrointestinal tract of animals and factors affecting their biodiversity. The composition of the microbial community ecosystem is dynamic and depends on many factors, including genes, medications, and feeding. Changes in the feeding diet can cause time shifts (within 24 hours) in a large number of microorganisms. It follows that feeding is also a vital regulator of the intestinal microbiota. The prospects for applying the results of the study of the microbiota of the body of farm animals are obvious, since they can become the basis for creating technologies that allow correcting undesirable changes in the microbiome of animals that arise as negative consequences of the intensification of highly productive agricultural production.
ВІДПОВІДАЛЬНЕ ТА ЕТИЧНЕ ВИКОРИСТАННЯ ШТУЧНОГО ІНТЕЛЕКТУ В ДОСЛІДНИЦЬКІЙ І ПУБЛІКАЦІЙНІЙ ДІЯЛЬНОСТІ
Authors: Пінчук Ольга , Малицька Ірина 
Published: April 2024

Artificial intelligence (AI) is gradually gaining a stable place in our lives, and its use is spreading too quickly in all areas of activity, changing approaches and simplifying the solution of some tasks. AI can help at certain stages of scientific research, but it also poses risks of plagiarism, lack of academic integrity and high ethical standards. The problem of plagiarism and its prevention in the research and publication process has reached a high degree of relevance, especially with the use of AI programs and services. The article presents a comprehensive analysis of scientific sources covering the prevention of plagiarism in scientific publications, the development of AI in research culture, the observance of academic integrity in the university environment, and changes in the assessment of students' academic achievements..Using the GoogleTrends service, based on the search engine's statistical data, it was determined that recently, scientific topics related to ChatGPT have been dominating in the queries of Internet users, while the discourse related to plagiarism, academic integrity, research ethics, and responsible use of AI is not noticeably relevant, and there is an increase in related queries between "plagiarism" and AI tools. The authors substantiate the impact of the use of AI on the responsible attitude to the presentation of research results. After processing the downloaded data in Excel, a hypothesis is formulated regarding the convergence of interests and joint consideration of the problems of ethics in research and responsible use of AI. The analysed data demonstrate that the relevance of ethical and responsible use of artificial intelligence tools in writing scientific manuscripts is extremely high. The article demonstrates how digital tools such as Connected Papers, Inciteful, LitMaps, Scite.Ai, ResearchRabbit, and Semantic Scholar can conveniently visualise documents related to search terms. The article offers recommendations for researchers and editorial board members of scientific journals to promote responsible presentation of research findings in the context of the growing availability and use of AI.
THE INFLUENCE OF EMOTIONAL INTELLIGENCE AND TIME MANAGEMENT ON THE SUCCESS OF MEMORIZING THE QUR'AN
Authors: Iqomatin Durrotul , Lina  
Published: April 2024

This research aimed to determine the existence of a positive and significant relationship between the level of emotional intelligence and time management and the success of memorizing the Qur'an and to find out how much influence it has on tahfiz students at Islamic Boarding School Bantul Yogyakarta An Nur (Al-Maghfiroh Complex). The research subjects were Islamic boarding school students at Madrasah Aliyah level, with a total of 78 students. Data collection used questionnaire methods and test methods. Instrument content validity analysis was carried out using the Aiken formula, while reliability estimation used Cronbach Alpha. Data analysis was carried out using multiple regression analysis. The results of this research showed that the variables emotional intelligence (X1) and time management (X2) had a strong, positive, and significant relationship with the success of memorizing the Qur'an. It was proven by correlation values (r) of 0.656 and 0.212. Together, the variables emotional intelligence (X1) and time management (X2) influence the success of memorizing the Qur’an (Y) by 54.5%. As for the remaining 45.5%, success in memorizing the Qur’an was influenced by other variables not explained in this research. Therefore, this research could contribute to students memorizing the Qur'an, thereby influencing their intelligence and the time management they carried out in the future learning process.
Effect of Varied Cure Temperature on the Cure Behavior, Mechanical Properties and Heat Build-Up of Solid Tire Tread Compound Containing Different Particles Sizes of Ground Tire Rubber
Authors: Umunakwe Reginald , Madueke Chioma Ifeyinwa , Umunakwe Ifeoma Janefrances , Adebayo Abdullahi Olawale , Oyetunji Akinlabi , Borisade Sunday Gbenga , Adigun Oluwole Daniel , Malomo Dosu 
Published: April 2024

This work investigates the effect of variation in vulcanization temperature on the cure behavior, tensile properties, tear strength, hardness, Akron abrasion loss and heat build-up of vulcanized tire tread compound in which the total rubber was replaced with 10% and 20% ground tire rubber (GTR) of 40, 60 and 80 mesh sizes. The first step was the characterization of the GTR using optical microscopy and a thermogravimetric analyzer. The first step of mixing each rubber compound was carried out using an internal mixer (Brabender) at 60°C and 40 rev/min rotor speed and the second step was done on a two-roll mill. The mooney viscosity of each rubber compound was investigated. the cure behavior of the rubber compounds was studied at 140°C, 150°C, and 160°C respectively. Results show that the introduction of GTR reduced vulcanization time, while increased cure temperature resulted in a lower vulcanization time. No significant difference was observed in the vulcanization time at a particular temperature of the rubber sample with different particle sizes and varied amounts of GTR. The introduction of ground tire rubber in the rubber vulcanizate however resulted in decreased tensile strength, tear strength and elongation, and increased hardness, abrasion resistance, modulus and heat build-up. An increase in the vulcanization temperature from 140°C to 150°C and 160°C did not impart a significant reduction in the tensile strength of the vulcanizates containing GTR. Vulcanization at higher temperatures resulted in reduced hardness, and modulus, slightly increased abrasion loss and increased elongation of the vulcanizates containing GTR. The heat build-up increased as the cure temperature increased. Generally, the control sample with no content of ground tire rubber exhibited the best properties. If GTR is to be introduced in rubber matrix at an amount up to 20%, the results suggest that 60 mesh size particles will impart better properties. The optimal vulcanization temperature recommended based on the findings from the work is 150°C.
Research on the facile regeneration of degraded cathode materials from spent LiNi0.5Co0.2Mn0.3O2 lithium-ion batteries
Authors: Yang Chen , Hao Yujia , Wang Jiayi , Zhang Mingdao , Song Li , Qu Jiaan 
Published: April 2024

Rational reusing the waste materials in spent batteries play a key role in the sustainable development for the future lithium-ion batteries. In this work, we propose an effective and facile solid-state-calcination strategy for the recycling and regeneration of the cathode materials in spent LiNi0.5Co0.2Mn0.3O2 (NCM523) ternary lithium-ion batteries. By systemic physicochemical characterizations, the stoichiometry, phase purity and elemental composition of the regenerated material were deeply investigated. The electrochemical tests confirm that the material characteristics and performances got recovered after the regeneration process. The optimal material was proved to exhibit the excellent capacity with a discharge capacity of 147.9 mAh g−1 at 1 C and an outstanding capacity retention of 86% after 500 cycles at 1 C, which were comparable to those of commercial NCM materials.
Effect of post-vitrification cryopreservation duration on singleton birth-weight in frozen-thawed blastocysts transfer cycles
Authors: Wang Xue , Xiao Yaling , Sun Zhengyi , Xiong Wei 
Published: April 2024

IntroductionThis study aimed to explore the effect of cryopreservation duration after blastocyst vitrification on the singleton birth-weight of newborns to assess the safety of long-term preservation of frozen–thawed blastocyst transfer (FBT) cycles.MethodsThis was a retrospective observational study conducted at the Gynecological Endocrinology and Assisted Reproduction Center of the Peking Union Medical College Hospital. Patients who gave birth to singletons between January 2006 and December 2021 after undergoing FBT cycles were included. Five groups were formed according to the duration of cryopreservation of embryos at FBT: Group I included 274 patients with a storage time &lt; 3 months. Group II included 607 patients with a storage time of 3–6 months. Group III included 322 patients with a storage time of 6–12 months. Group IV included 190 patients with a storage time of 12–24 months. Group V included 118 patients with a storage time of &gt; 24 months. Neonatal outcomes were compared among the groups. Multivariate linear regression analysis was performed to evaluate birth-weights and other birth-related outcomes.ResultsA total of 1,511 patients were included in the analysis. The longest cryopreservation period was 12 years. The birth-weights of neonates in the five groups were 3344.1 ± 529.3, 3326.1 ± 565.7, 3260.3 ± 584.1, 3349.9 ± 582.7, and 3296.7 ± 491.9 g, respectively (P &gt; 0.05). The incidences of preterm birth, very preterm birth, low birth-weight, and very low birth-weight were similar in all groups (P &gt; 0.05). The large-for-gestational-age and small-for-gestational-age rates did not differ significantly among the groups (P &gt; 0.05). After adjusting for confounding factors that may affect neonatal outcomes, a trend for an increased risk of low birth-weight with prolonged cryopreservation was observed. However, cryopreservation duration and neonatal birth-weight were not significantly correlated (P &gt; 0.05).ConclusionThe duration of cryopreservation after blastocyst vitrification with an open device for more than 2 years had no significant effect on the birth-weight of FBT singletons; however, attention should be paid to a possible increase in the risk of low birth-weight.
VELVET: an enclosure vegetation system to measure BVOC emission fingerprints in temperate and tropical climates
Authors: Rocco Manon , Brugere Etienne , Magand Olivier , Borbon Agnes , Colomb Aurelie , Bouvier Laetitia , Baray Jean-Luc , Duflot Valentin , Ribeiro Mickael , Picard David , Metzger Jean-Marc , Stamenoff Pierre , Benoit Yoan , Ah-Peng Claudine 
Published: April 2024

The VELVET chamber, utilizing the vegetation enclosure technique, was used to measure biogenic volatile organic compound (BVOC) emissions from representative plant leaves in temperate and tropical climates. This study demonstrates the instrument’s capability, among the various measurements conducted in other studies using the vegetation enclosure technique, in qualifying and quantifying volatile organic compound (VOC) emissions from different tree species. The measurements were performed using Tenax tubes for sampling and GC/MS analysis. The use of PTR-ToF-MS for temperate species allows us to perform flux measurements in the chamber of Norway spruce (Picea abies), European beech (Fagus sylvatica), and common hazel tree (Corylus avellana) in the Puy de Dôme region (France). We found that all species are monoterpene emitters (on average 1.52 ± 0.29 ng m−2 s−1) and more particularly sesquiterpene emitters for C. avellana (7.49 ± 0.70 ng m−2 s−1). In the tropical region of Réunion Island (France), comprehensive measurements were conducted across three distinct vegetation types, on 10 of the most representative species, native and exotic to the island. The study revealed that emissions from these species were influenced by spatial variability, their environment, and the type of the forest (cloud forest, and high- and low-altitude forests). Notably, the research marked a groundbreaking achievement by capturing emissions from endemic species on the island for the first time. The collected data will be added to the biogenic emission inventory of the island, thereby enhancing model simulations by incorporating these new measurements.
Total eosinophil count as a biomarker for therapeutic effects of upadacitinib in atopic dermatitis over 48 weeks
Authors: Hagino Teppei , Hamada Risa , Yoshida Mai , Fujimoto Eita , Saeki Hidehisa , Kanda Naoko 
Published: April 2024

BackgroundAtopic dermatitis (AD) is a chronic skin disease characterized by type 2-skewed immune responses, and significantly influenced by cytokines dependent on Janus kinases (JAKs). Upadacitinib, a JAK1 inhibitor, is effective for moderate-to-severe AD. This study aims to identify biomarkers that reflect long-term therapeutic effects of upadacitinib 15 mg or 30 mg.MethodsA retrospective study from August 2021 to July 2023 included 213 AD patients treated with upadacitinib 15 mg and 70 AD patients with 30 mg. We analyzed eczema area and severity index (EASI), peak pruritus-numerical rating scale (PP-NRS), serum immunoglobulin E (IgE), thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), and total eosinophil count (TEC) at weeks 0, 4, 12, 24, 36, and 48 of treatment.ResultsBoth treatments with upadacitinib 15 mg and 30 mg significantly reduced EASI and PP-NRS scores over week 4 to 48 compared to baseline. Upadacitinib 15 mg or 30 mg treatment significantly decreased TEC compared to baseline through week 4 to 36 or week 4 to 48, respectively. The percent reduction of TEC correlated with those of EASI and PP-NRS through week 4 to 48 of treatment with upadacitinib 15 mg, or through week 12 to 48 with 30 mg, respectively. After adjusting for % reductions of other laboratory markers, the significance of correlations was preserved at weeks 36 and 48 of 15 mg treatment, while at weeks 4 and 36 of 30 mg treatment.ConclusionThe % reduction of TEC correlated with those of EASI and PP-NRS during upadacitinib treatment, indicating its potential as a biomarker reflecting treatment responses to upadacitinib in AD patients. However, the variability of significant correlation during treatment indicates that further inspection is needed for its usefulness in monitoring responses to upadacitinib treatment for AD.
Heterogeneity of immune cells and their communications unveiled by transcriptome profiling in acute inflammatory lung injury
Authors: Kang Zhi-ying , Huang Qian-yu , Zhen Ning-xin , Xuan Nan-xia , Zhou Qi-chao , Zhao Jie , Cui Wei , Zhang Zhao-cai , Tian Bao-ping 
Published: April 2024

BackgroundAcute Respiratory Distress Syndrome (ARDS) or its earlier stage Acute lung injury (ALI), is a worldwide health concern that jeopardizes human well-being. Currently, the treatment strategies to mitigate the incidence and mortality of ARDS are severely restricted. This limitation can be attributed, at least in part, to the substantial variations in immunity observed in individuals with this syndrome.MethodsBulk and single cell RNA sequencing from ALI mice and single cell RNA sequencing from ARDS patients were analyzed. We utilized the Seurat program package in R and cellmarker 2.0 to cluster and annotate the data. The differential, enrichment, protein interaction, and cell-cell communication analysis were conducted.ResultsThe mice with ALI caused by pulmonary and extrapulmonary factors demonstrated differential expression including Clec4e, Retnlg, S100a9, Coro1a, and Lars2. We have determined that inflammatory factors have a greater significance in extrapulmonary ALI, while multiple pathways collaborate in the development of pulmonary ALI. Clustering analysis revealed significant heterogeneity in the relative abundance of immune cells in different ALI models. The autocrine action of neutrophils plays a crucial role in pulmonary ALI. Additionally, there was a significant increase in signaling intensity between B cells and M1 macrophages, NKT cells and M1 macrophages in extrapulmonary ALI. The CXCL, CSF3 and MIF, TGFβ signaling pathways play a vital role in pulmonary and extrapulmonary ALI, respectively. Moreover, the analysis of human single-cell revealed DCs signaling to monocytes and neutrophils in COVID-19-associated ARDS is stronger compared to sepsis-related ARDS. In sepsis-related ARDS, CD8+ T and Th cells exhibit more prominent signaling to B-cell nucleated DCs. Meanwhile, both MIF and CXCL signaling pathways are specific to sepsis-related ARDS.ConclusionThis study has identified specific gene signatures and signaling pathways in animal models and human samples that facilitate the interaction between immune cells, which could be targeted therapeutically in ARDS patients of various etiologies.