bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acid‐sensing ion channel 1: A novel therapeutic target for migraine with aura
Authors: Holland Philip R. , Akerman Simon , Andreou Anna P. , Karsan Nazia , Wemmie John A. , Goadsby Peter J. 
Published: May 2012

AbstractObjective:Migraine with aura is a severe debilitating neurological disorder with few relatively specific therapeutic options.Methods:We used amiloride, a blocker of epithelial sodium channels, to evaluate its pharmacological potential and explored the biology of a potential mechanism of action in well‐established experimental models.Results:Amiloride was shown to block cortical spreading depression, the experimental correlate of aura, and inhibited trigeminal activation in in vivo migraine models, via an acid‐sensing ion channel 1 mechanism. Remarkably, amiloride then demonstrated good clinical efficacy in a small open‐labeled pilot study of patients, reducing aura and headache symptoms in 4 of 7 patients with otherwise intractable aura.Interpretation:The observations here identify an entirely novel treatment strategy for migraine. ANN NEUROL 2012;72:559–563
Major, non‐chromosomal, birth defects and maternal physical activity: A systematic review
Authors: Flak Audrey L. , Yun Tark Ji , Tinker Sarah C. , Correa Adolfo , Cogswell Mary E. 
Published: May 2012

AbstractBACKGROUNDWe reviewed the published literature to assess the association between maternal periconceptional physical activity and the risk for major, non‐chromosomal, birth defects and whether this varies by pre‐pregnancy obesity.METHODSWe conducted a systematic literature search of MEDLINE, EMBASE, and CINAHL databases. Data were abstracted from all articles that met our inclusion criteria and included information on physical activity intensity (mild, moderate, and vigorous) and modality (i.e., standing, lifting, other). We assessed occupational and recreational physical activity separately. The quality of included articles was assessed using the Newcastle–Ottawa Scale.RESULTSOf 3316 screened articles, 11 were included in this review. Of the four studies that assessed prolonged standing, two reported a positive association with risk for some birth defects; null associations were observed in the other two studies. Associations between heavy lifting or other occupational physical activity exposures and risk for birth defects were inconsistent. A protective association between leisure‐time physical activity (i.e., active sports, swimming) and some birth defects (e.g., neural tube defects), was suggested by the results of two studies. Only one study reported assessment of possible effect modification by maternal body mass index (BMI).DISCUSSIONOur review suggests that there may be some associations between occupational and leisure‐time physical activities and some, major non‐chromosomal, birth defects, but relatively limited published research exists on these associations. Further research in this area should include differentiation of birth defects phenotypes, valid assessments of all domains of physical activity, including household and transportation activity, and account for the potential influence of pre‐pregnancy BMI. Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc.
DFT Study of Steam Reforming of Formaldehyde on Cu, PdZn, and Ir
Authors: Li Xiang , Lim Kok Hwa 
Published: May 2012

AbstractDensity functional theory has been used in this study to investigate the steam reforming of formaldehyde and its reaction intermediates on Cu (2 2 1), PdZn (1 0 0), and Ir (1 0 0) surfaces. The adsorption complexes (CH2O, H2COOH, H2COO, HCOO, COOH, etc.), binding energies, and reaction energies involved in the steam reforming and dehydrogenation of formaldehyde have been systematically characterized. Our results showed that CH2O dehydrogenation is the dominant pathway for Ir (1 0 0). In contrast, desorption of CH2O is more favorable than dehydrogenation on regular Cu and PdZn (1 0 0) surfaces and the steam reforming reaction is likely to occur at defect sites such as the Cu (2 2 1) surface.
ChemInform Abstract: Solution‐Phase Monitoring of the Structural Evolution of a Molybdenum Blue Nanoring.
Authors: Miras Haralampos N. , Richmond Craig J. , Long De‐Liang , Cronin Leroy 
Published: May 2012

AbstractThe inorganic host—guest complex Na22{ [MoVI36O112(H2O)16] [MoVI130MoV20O442 (OH)10(H2O)61]}·180H2O (I) is synthesized in a flow reactor from aqueous solutions of Na2MoO4, HCl, and Na2S2O4 reacting in a mixing chamber at a flow rate of 4—6 mL/h.
ChemInform Abstract: Complex Clover Cross‐Sectioned Nanotubes Exist in the Structure of the First Uranium Borate Phosphate.
Authors: Wu Shijun , Wang Shuao , Diwu Juan , Depmeier Wulf , Malcherek Thomas , Alekseev Evgeny V. , Albrecht‐Schmitt Thomas E. 
Published: May 2012

AbstractBa5 [(UO2)(PO4)3(B5O9)] (H2O)0.125 is synthesized by solid state reaction of H3BO3, BPO4, UO2(NO3)2·6H2O, and BaCO3 (Pt crucible, 1000 °C, slow cooling to room temperature, 8—10% yield).
ChemInform Abstract: High‐Nuclearity 3d—4f Clusters as Enhanced Magnetic Coolers and Molecular Magnets.
Authors: Peng Jun‐Bo , Zhang Qian‐Chong , Kong Xiang‐Jian , Zheng Yan‐Zhen , Ren Yan‐Ping , Long La‐Sheng , Huang Rong‐Bin , Zheng Lan‐Sun , Zheng Zhiping 
Published: May 2012

AbstractThe CoII/CoIII (9:1) mixed compounds (III) and the NiII compounds (V) are isostructural and crystallize in the monoclinic space group P21/m with Z = 2 (single crystal XRD).
ChemInform Abstract: Electronic Tuning of Chiral Diene Ligands in Iridium‐Catalyzed Asymmetric 1,6‐Addition of Arylboroxines to δ‐Aryl‐α,β,γ,δ‐unsaturated Ketones.
Authors: Nishimura Takahiro , Noishiki Akira , Hayashi Tamio 
Published: May 2012

AbstractHighly enantioselective addition of arylboroximes to the title unsaturated ketones is achieved in the presence of an iridium catalyst coordinated to a chiral benzobarrelene derivative (bar).
ChemInform Abstract: Enhancement of Enantioselectivity by Alcohol Additives in Asymmetric Hydrogenation with Bis(oxazolinyl)phenyl Ruthenium Catalysts.
Authors: Ito Jun‐ichi , Teshima Tomoki , Nishiyama Hisao 
Published: May 2012

AbstractThe chiral bulky (9‐anthracenyl)ethanol enhances the enantioselectivities up to 50% in the asymmetric hydrogenation of prochiral ketones, even in protic solvents.
ChemInform Abstract: Development of the Enantioselective Addition of Ethyl Diazoacetate to Aldehydes: Asymmetric Synthesis of 1,2‐Diols.
Authors: Trost Barry M. , Malhotra Sushant , Koschker Philipp , Ellerbrock Pascal 
Published: May 2012

AbstractThe title method is applied to the synthesis of vicinal diols bearing a tertiary carbon center.
ChemInform Abstract: Gold(I)‐Catalyzed Enantioselective Intramolecular Dehydrative Amination of Allylic Alcohols with Carbamates.
Authors: Mukherjee Paramita , Widenhoefer Ross A. 
Published: May 2012

AbstractBy use of an optimized catalyst system, vinyl‐substituted pyrrolidine, piperidine, and piperazine compounds are formed with up to 95% enantioselectivity.
ChemInform Abstract: Divergent Amine‐Catalyzed [4 + 2] Annulation of Morita—Baylis—Hillman Allylic Acetates with Electron‐Deficient Alkenes.
Authors: Xu Silong , Chen Rongshun , Qin Zifeng , Wu Guiping , He Zhengjie 
Published: May 2012

AbstractThe process provides easy access to highly functionalized cyclic compounds.
ChemInform Abstract: Iridium‐Catalyzed Addition of Aroyl Chlorides and Aliphatic Acid Chlorides to Terminal Alkynes.
Authors: Iwai Tomohiro , Fujihara Tetsuaki , Terao Jun , Tsuji Yasushi 
Published: May 2012

AbstractThe ligands in the iridium catalytic system play a crucial role for the success of the reactions.
ChemInform Abstract: A Domino Approach of Heck Coupling for the Synthesis of β‐Trifluoromethylstyrenes.
Authors: Prakash G. K. Surya , Krishnan Hema S. , Jog Parag V. , Iyer Anjali P. , Olah George A. 
Published: May 2012

AbstractThe efficient, simple method gives an access to some previously unknown compounds avoiding the use of low‐boiling, gaseous reagents.
ChemInform Abstract: Efficient Iron(III)‐Catalyzed Three‐Component Coupling Reaction of Alkynes, CH2Cl2 and Amines to Propargylamines.
Authors: Gao Jian , Song Qing‐Wen , He Liang‐Nian , Yang Zhen‐Zhen , Dou Xiao‐Yong 
Published: May 2012

AbstractAn economical and facile protocol for the synthesis of propargyl amines is reported.
ChemInform Abstract: Peroxide‐Mediated Transition‐Metal‐Free Direct Amidation of Alcohols with Nitroarenes.
Authors: Xiao Fuhong , Liu Yong , Tang Chenglin , Deng Guo‐Jun 
Published: May 2012

AbstractThe reaction shows very good selectivity: amides are formed as the major products, and only trace amounts of imine by‐products are obtained in most cases.
ChemInform Abstract: An Efficient Method for the Preparation of Mono α‐Aryl Derivatives of Diethyl Malonate and Ethyl Cyanoacetate Using Ethyl‐1‐imidazole Carbamate (EImC).
Authors: Behera Manoranjan , Ragavan R. Venkat , Sambaiah M. , Erugu Balaiah , Reddy J. Rama Krishna , Mukkanti K. , Yennam Satyanarayana 
Published: May 2012

AbstractA simple approach to the title compounds, which are required as synthons of heterocycles, becomes possible by treatment of arylacetic esters (II) and nitriles (IV) with reagent (I).
ChemInform Abstract: Iron‐Catalyzed Selective Oxidation of Sulfides to Sulfoxides with the Polyethylene Glycol/O2 System.
Authors: Li Bin , Liu An‐Hua , He Liang‐Nian , Yang Zhen‐Zhen , Gao Jian , Chen Kai‐Hong 
Published: May 2012

AbstractAliphatic and aromatic sulfides are transformed into the corresponding sulfoxides with high selectivity by using molecular oxygen as the oxidant in polyethylene glycol in the presence of Fe(acac)2 as the catalyst.
ChemInform Abstract: Bi(III)‐Catalyzed Intermolecular Reactions of (Z)‐Pent‐2‐ene‐4‐ynyl Acetates with Ethynylarenes for the Construction of Multisubstituted Fluorene Skeletons Through a Cascade Electrophilic Addition/Cycloisomerization Sequence.
Authors: Wang Xiang‐Chuan , Yan Ru‐Long , Zhong Mei‐Jin , Liang Yong‐Min 
Published: May 2012

AbstractIt provides a straightforward approach to multisubstituted fluorenes and related compounds.
ChemInform Abstract: Generation of Metalated Thiophenes with Grignard Reagent and Catalytic Secondary Amine for the Cross‐Coupling Reaction with Aryl Halides.
Authors: Tanaka Shota , Tanaka Daiki , Sugie Atsushi , Mori Atsunori 
Published: May 2012

AbstractThiophenes and benzofuran are metalated in 2‐position under conditions A), followed by Ni‐ or Pd‐catalyzed cross‐coupling with aryl halides.
ChemInform Abstract: Hydrogen‐Bond‐Mediated Cascade Reaction Involving Chalcones: Facile Synthesis of Enantioenriched Trisubstituted Tetrahydrothiophenes.
Authors: Ling Jun‐Bing , Su Yu , Zhu Hai‐Liang , Wang Guan‐Yu , Xu Peng‐Fei 
Published: May 2012

AbstractTarget compounds with three stereogenic centers are directly obtained from commercially available materials with a low catalyst loading.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of Terminal Acetals via Highly Selective anti‐Markovnikov Nucleophilic Attack of Pinacol on Vinylarenes, Allyl Ethers, and 1,5‐Dienes.
Authors: Yamamoto Mayumi , Nakaoka Sonoe , Ura Yasuyuki , Kataoka Yasutaka 
Published: May 2012

AbstractIn the presented reaction, the sterical bulkiness of pinacol (II) controls the regioselectivity in an anti‐Markovnikov manner.
ChemInform Abstract: Syntheses of Cyclic Carbonates with Amidinium Halide Catalysts in Reusable, Reversible, Room‐Temperature Ionic Liquids or Acetonitrile.
Authors: Yu Tao , Weiss Richard G. 
Published: May 2012

AbstractReaction between epoxides (I) and carbon dioxide (II) in room temperature ionic liquids and in the presence of an amidinium halide catalyst occurs cleanly to provide the cyclic carbonates (III), exclusively.
ChemInform Abstract: Sc(OTf)3‐Catalyzed, Solvent‐Free Domino Synthesis of Functionalized Pyrazoles under Controlled Microwave Irradiation.
Authors: Kumari Kumkum , Raghuvanshi Dushyant Singh , Jouikov Viatcheslav , Singh Krishna Nand 
Published: May 2012

AbstractOptimized conditions are developed for the three‐component reaction to give highly functionalized pyrazoles for drug development.
ChemInform Abstract: An Efficient One‐Pot Synthesis of 1‐Amino‐3‐cyano‐4‐aryl‐10‐ethoxycarbonylazuleno[2,1‐b]pyrans
Authors: Wang Dao‐lin , Feng Shan‐Shan , Cui Qing‐Tao , Yu Jia‐Yi 
Published: May 2012

Abstractvia DABCO‐catalyzed three‐component condensation of 2‐hydroxyazulenecarboxylate (I) with malononitrile and aromatic aldehydes; 14 examples
ChemInform Abstract: N‐Heterocyclic Carbene Cascade Catalysis: Dual Broensted/Lewis Base Rearrangement of Cyclopropyl Enol Esters to Dihydropyranones.
Authors: Candish Lisa , Lupton David W. 
Published: May 2012

AbstractThe scope and mechanistic studies implicate that the title reaction proceeds via a novel electrocyclic cyclopropane rearrangement followed by an anionic oxy Claisen‐rearrangement.
ChemInform Abstract: A Stereoselective Hydroamination Transform to Access Polysubstituted Indolizidines.
Authors: Pronin Sergey V. , Tabor M. Greg , Jansen Daniel J. , Shenvi Ryan A. 
Published: May 2012

AbstractThe indolizines are accessed from simple dieneamines by an intramolecular, diastereo‐, regio‐, and chemoselective directed hydroboration/oxidative migration strategy.
ChemInform Abstract: Microwave‐Enhanced Suzuki Coupling: A Diversity‐Oriented Approach to the Synthesis of Highly Functionalized 3‐Substituted‐2‐aryl/heteroaryl Imidazo[4,5‐b]pyridines.
Authors: Sajith Ayyiliath M. , Muralidharan A. 
Published: May 2012

AbstractA modified approach using (A‐taphos)2PdCl2 as optimal catalyst allows the synthesis of various title compounds from iodo precursors (I) and (IV) for medicinal studies.
ChemInform Abstract: Straightforward Palladium‐Mediated Synthesis and Biological Evaluation of Benzo[j]phenanthridine‐7,12‐diones as Antituberculosis Agents.
Authors: Huygen Kris , et al. et al. 
Published: May 2012

AbstractA variety of benzophenanthridines (VII) (8 examples) is prepared by palladium‐catalyzed intramolecular cyclization of bromides (VI).
ChemInform Abstract: Synthesis and Biological Activity of Ethyl 2‐(Substituted benzylthio)‐4‐(3′‐ (ethoxycarbonyl)biphenyl‐4‐yl) ‐6‐methyl‐1,4‐dihydropyrimidine‐5‐carboxylate Derivatives.
Authors: Maddila Suresh , Jonnalagadda Sreekantha B. 
Published: May 2012

AbstractTitle compounds (VII), synthesized starting from aldehyde (I) via a multicomponent reaction, are found to possess good to excellent antifungal (compared to amphotericin) and antibacterial (compared to ciprofloxacin) activity.
ChemInform Abstract: AlCl3‐Induced C‐Arylation/Cyclization in a Single Pot: A New Route to Benzofuran‐ Fused N‐Heterocycles of Pharmacological Interest.
Authors: Kumar K. Shiva , Adepu Raju , Kapavarapu Ravikumar , Rambabu D. , Krishna G. Rama , Reddy C. Malla , Priya K. Krishna , Parsa Kishore V. L. , Pal Manojit 
Published: May 2012

AbstractThe AlCl3‐mediated cyclocondensation of 2,3‐dichloropyrazine derivatives with 2‐naphthol or resorcinol monoalkyl ethers offers a direct synthesis of various polycyclic bis‐fused furan derivatives.
ChemInform Abstract: Synthesis of Benzoxazines, Quinazolines and 4H‐Benzo[e][1,3]thiazine by ANRORC Rearrangements of 1,2,4‐Oxadiazoles.
Authors: Draghici Bogdan , El‐Gendy Bahaa El‐Dien M. , Katritzky Alan R. 
Published: May 2012

Abstract1,2,4‐Oxadiazoles bearing an aryl group with a nucleophilic substituent at the ortho‐position react with BuLi via addition reaction, ring opening, and ring closing to give the title heterocycles in moderate yields.
ChemInform Abstract: Preparation of New Nitrogen‐Bridged Heterocycles. Part 75. Novel Rearrangements of a 8aH‐Pyrido[1,2‐d]thieno[2′,3′‐b][1,4]thiazepine Derivative.
Authors: Kakehi Akikazu , Itoh Kennosuke , Suga Hiroyuki , Ohkubo Yuuki , Kobayashi Ayaka , Nishi Takashi 
Published: May 2012

AbstractThe reaction of thiolate (I) with alkyne (II) in THF gives rise to tetracyclic derivative (III), whilst the reaction in chloroform leads to pyrrolothienothiazocine (IV).
ChemInform Abstract: Highly Enantioselective Synthesis of Silahelicenes Using Ir‐Catalyzed [2 + 2 + 2] Cycloaddition.
Authors: Shibata Takanori , Uchiyama Toshifumi , Yoshinami Yusuke , Takayasu Satoshi , Tsuchikama Kyoji , Endo Kohei 
Published: May 2012

AbstractThe first synthesis of silahelicenes (IV), which have helical chirality including silole moieties, is reported.
ChemInform Abstract: Shuffle off the Classic β‐Si Elimination by Ni‐NHC Cooperation: Implication for C—C Forming Reactions Involving Ni‐Alkyl‐β‐silanes
Authors: Ho Chun‐Yu , He Lisi 
Published: May 2012

AbstractVia cooperation of an NHC, Si substituents and metal center, β‐Si elimination is attenuated revealing a new way to attain a high amount of Ni‐β‐SiR3.
ChemInform Abstract: Enantioselective Synthesis of Quaternary α‐Aminophosphonates via Conjugate Addition of α‐Nitrophosphonates to Enones.
Authors: Bera Kalisankar , Namboothiri Irishi N. N. 
Published: May 2012

AbstractThe reaction proceeds in the presence of a new alkaloid‐derived thiourea catalyst.The scope of enones and nitrophosphonates investigated suggests that electron‐rich aryl vinyl ketones (I) are excellent substrates.
ChemInform Abstract: Synthesis of Enantiomerically Pure anti‐1,2‐Diaryl and syn‐1, 2‐Alkylaryl vic‐Selenoamines.
Authors: Garcia Ruano Jose L. , Torrente Esther , Alonso Ines , Rodriguez Mercedes , Martin‐Castro Ana M. , Degl'Innocenti Alessandro , Frateschi Lucrezia , Capperucci Antonella 
Published: May 2012

AbstractTreatment of selenide (I) with the sulfinylarylimines (II) allows highly stereoselective formation of anti‐1,2‐diaryl selenoamines.
ChemInform Abstract: Tumonoic Acids K and L, Novel Metabolites from the Marine‐Derived Fungus Penicillium citrinum
Authors: Chen Li , Huang Kai , Zhong Ping , Hu Xiao , Fang Zhe‐Xiang , Wu Jiu‐lin , Zhang Qi‐Qing 
Published: May 2012

Abstractisolation, structure and cytotoxicity of new ester (II) and epimeric tumonoic acids (I) as well as nine known compounds
ChemInform Abstract: Exo‐ and Endohormones. Part 24. A Convenient Synthesis of (Z)‐11‐Tetradecen‐1‐yl Acetate, Component of Lepidoptera Insect Sex Pheromone.
Authors: Gansca Lucia , Andreica Adriana , Ciotlaus Irina , Maxim Sanda , Oprean Ioan 
Published: May 2012

AbstractTitle compound (V) is synthesized starting from diol (I) using the lithiation and subsequent alkylation of di(t‐butoxy‐dodecyne)mercury (II) as the key step.
ChemInform Abstract: Potent Antioxidant and Lipoxygenase Inhibitory Flavanone and Chalcone from Erythrina mildbraedii Harms (Fabaceae) of Cameroon.
Authors: Ali Muhammad Shaiq , Ali Muhammad Imran , Ahmed Ghafoor , Afza Nighat , Lateef Mehreen , Iqbal Lubna , Waffo Alain F. K. , Ahmed Zeeshan 
Published: May 2012

AbstractThe new flavanone, mildbone (I), and the new chalcone, mildbenone (II), show significant antioxidant and moderate lipoxygenase inhibitory activities.
Tuning the Dimensions of ZnO Nanorod Arrays for Application in Hybrid Photovoltaics
Authors: Baeten Linny , Conings Bert , D'Haen Jan , De Dobbelaere Christopher , Hardy An , Manca Jean V. , Van Bael Marlies K. 
Published: May 2012

AbstractZnO nanorod arrays are a very eligible option as electron acceptor material in hybrid solar cells, owing to their favorable electrical properties and abundance of available, easy, and low‐cost synthesis methods. To become truly effective in this field, a major prerequisite is the ability to tune the nanorod dimensions towards optimal compatibility with electron‐donating absorber materials. In this work, a water‐based seeding and growth procedure is used to synthesize ZnO nanorods. The nanorod diameter is tuned either by modifying the zinc concentration of the seeding solution or by changing the concentration of the hydrothermal growth solution. The consequences of this morphological tailoring in the performance of hybrid solar cells are investigated, which leads to a new record efficiency of 0.82 % for hydrothermally grown ZnO nanorods of size 300 nm in combination with poly(3‐hexylthiophene‐2,5‐diyl) (P3HT). This improvement is attributed to a combined effect of nanorod diameter and orientation, and possibly to a better alignment of the P3HT backbone resulting in improved charge transport.
Synthesis of lead telluride particles by thermal decomposition method for thermoelectric applications
Authors: Leontyev V. G. , Ivanova L. D. , Bente K. , Lazenka V. V. , Gremenok V. F. 
Published: May 2012

AbstractThe lead telluride fine crystalline particles were synthesized using thermal decomposition and chemical interaction of lead acetate and tellurium powder mixture in reducing atmosphere (H2). For the process control, thermal gravimetry (TG), the different‐scanning calorimetry (DSC), X‐ray diffraction (XRD), electronic microscopy (SEM) and measurements of the specific surface of particles were used. Additionally the influence of gas phases on the decomposition kinetics, crystal structure, size, specific surface of the particles and the physical properties were analyzed. Seebeck coefficient values increased with decreasing synthesis temperature and increasing specific surfaces of the powder. The presented method of preparing lead telluride polydisperse particles is developed to create nano‐structured thermoelectric materials with high figure of merit.
Luminescent properties of CsI single crystals grown from the melt treated with EuI2
Authors: Cherginets V. L. , Rebrova T. P. , Datsko Yu. N. , Goncharenko V. F. , Kosinov N. N. , Yavetsky R. P. , Pedash V. Yu. 
Published: May 2012

AbstractCsI single crystals treated with EuI2 as a scavenger are grown and their radioluminescence spectra and scintillation light decay curves are obtained. Addition of the quantities of the scavenger comparable with the total concentration of the oxygen‐containing admixtures in the melt results in complete destruction of the latter. In its turn, this causes the disappearance of the band with a maximum at 2.8 eV in the radioluminescence spectrum and decreases the fraction of the slow 2 µs‐component to 0.01. The addition of larger quantities of EuI2 leads to the appearance of a wide band with the maximum at 2.8 eV characterized by a decay constant of 2 µs; its intensity increases with the EuI2 concentration. The maximum ratio of two faster components with the decay constants equal to 7 and 30 ns approaches 0.58:0.41 at EuI2 concentration in CsI melt equal to 0.01 mol·kg−1.
Carbonization and Activation of Inexpensive Semicoke‐Packed Electrodes to Enhance Power Generation of Microbial Fuel Cells
Authors: Wei Jincheng , Liang Peng , Zuo Kuichang , Cao Xiaoxin , Huang Xia 
Published: May 2012

AbstractA simple and low‐cost modification method was developed to improve the power generation performance of inexpensive semicoke electrode in microbial fuel cells (MFCs). After carbonization and activation with water vapor at 800–850 °C, the MFC with the activated coke (modified semicoke) anode produced a maximum power density of 74 W m−3, 17 W m−3, and 681 mW m−2 (normalized to anodic liquid volume, total reactor volume, and projected membrane surface area, respectively), which was 124 % higher than MFCs using a semicoke anode (33 W m−3, 8 W m−3, and 304 mW m−2). When they were used as biocathode materials, activated coke produced a maximum power density of 177 W m−3, 41 W m−3, and 1628 mW m−2 (normalized to cathodic liquid volume, total reactor volume, and projected membrane surface area, respectively), which was 211 % higher than that achieved by MFCs using a semicoke cathode (57 W m−3, 13 W m−3, and 524 mW m−2). A substantial increase was also noted in the conductivity, C/O mass ratio, and specific area for activated coke, which reduced the ohmic resistance, increased biomass density, and promoted electron transfer between bacteria and electrode surface. The activated coke anode also produced a higher Coulombic efficiency and chemical oxygen demand removal rate than the semicoke anode.