bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication, encapsulation and controlled release of multilayer capsule based on thermosensitivity and host‐guest interaction
Authors: Wang Yuhang , Liu Mingyang , Hu Zhengsheng , Lv Hanlin , Chen Yanjun , Wang Yifeng 
Published: May 2024

AbstractAs an efficient means of material carrying, multilayer capsules are widely used in medicine, agriculture, food safety and other fields. Here, we report a kind of temperature‐triggered multilayer capsule with chitosan‐sodium dodecyl benzene sulfonate (CS‐SDBS) as the shell and gelatin bead containing α‐cyclodextrin (α‐CD@gelatin) as the core. The α‐CD@gelatin/CS‐SDBS multilayer capsules can simultaneously encapsulate various substances, such as drugs, fluorescent materials, and nanoparticles. The encapsulated substances do not interfere with each other because they are located in different layers. Both the temperature‐sensitive property of gelatin and the host‐guest interaction between α‐CD and SDBS are utilized to achieve temperature‐controlled release of substances in the multilayer capsules. The release rate can be adjusted by the α‐CD amount in the gelatin beads. The controlled drug release and chemical detection of the multilayer capsules are studied with sodium salicylate, iodine, and purple cabbage pigment as the carriers. The results show that the α‐CD@gelatin/CS‐SDBS multilayer capsules have excellent capabilities of encapsulation and controlled release, which are beneficial for their application in the fields of substance encapsulation, drug‐controlled release, and chemical detection.
Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B–NS3 protease
Authors: Huber Simon , Braun Niklas J. , Schmacke Luna C. , Murra Robin , Bender Daniela , Hildt Eberhard , Heine Andreas , Steinmetzer Torsten 
Published: May 2024

AbstractThree new series of macrocyclic active site‐directed inhibitors of the Zika virus (ZIKV) NS2B–NS3 protease were synthesized. First, attempts were made to replace the basic P3 lysine residue of our previously described inhibitors with uncharged and more hydrophobic residues. This provided numerous compounds with inhibition constants between 30 and 50 nM. A stronger reduction of the inhibitory potency was observed when the P2 lysine was replaced by neutral residues, all of these inhibitors possess Ki values >1 µM. However, it is possible to replace the P2 lysine with the less basic 3‐aminomethylphenylalanine, which provides a similarly potent inhibitor of the ZIKV protease (Ki = 2.69 nM). Crystal structure investigations showed that the P2 benzylamine structure forms comparable interactions with the protease as lysine. Twelve additional structures of these inhibitors in complex with the protease were determined, which explain many, but not all, SAR data obtained in this study. All individual modifications in the P2 or P3 position resulted in inhibitors with low antiviral efficacy in cell culture. Therefore, a third inhibitor series with combined modifications was synthesized; all of them contain a more hydrophobic d‐cyclohexylalanine in the linker segment. At a concentration of 40 µM, two of these compounds possess similar antiviral potency as ribavirin at 100 µM. Due to their reliable crystallization in complex with the ZIKV protease, these cyclic compounds are very well suited for a rational structure‐based development of improved inhibitors.
Pulsed electromagnetic fields used in regenerative medicine: An in vitro study of the skin wound healing proliferative phase
Authors: Bedja‐Iacona Léa , Scorretti Riccardo , Ducrot Marie , Vollaire Christian , Franqueville Laure 
Published: May 2024

AbstractNumerous studies have demonstrated the efficacy of extremely low frequency‐pulsed electromagnetic fields (ELF‐PEMF) in accelerating the wound healing process in vitro and in vivo. Our study focuses specifically on ELF‐PEMF applied with the Magnomega® device and aims to assess their effect during the main stages of the proliferative phase of dermal wound closure, in vitro. Thus, after the characterization of the EMFs delivered by the Magnomega® unit, primary culture of human dermal fibroblasts (HDFs) were exposed, or not for the control culture, to 10–12 and 100 Hz ELF‐PEMF. These parameters are used in clinical practice by physiotherapists in order to enhance healing of dermal lesions in patients. HDFs proliferation was first assessed and revealed an increase in the expression of one of the two genetic markers of cell proliferation tested (PCNA and MKI67), after initial exposure of the cells to 10–12 Hz PEMF. Next, migration of HDFs was investigated by performing scratch assays on HDF layers. The observed wound closure kinetics corroborate the early organization of actin stress fibers that was revealed in the cytoplasm of HDFs exposed to 100 Hz ELF‐PEMF. Also, maturation of HDFs into myofibroblasts was significantly increased in cells exposed to 10–12 or to 100 Hz PEMF. The present study is the first to demonstrate, in vitro, an early stimulation of HDFs, after their exposure to ELF‐PEMF delivered by the Magnomega® device, which could contribute to an acceleration of the wound healing process.
Das DBV‐Merkblatt Frischbetonverbundsysteme für eine geregelte Bauart
Authors: Filusch Sebastian , Fingerloos Frank , Meyer Lars , Urban Susanne 
Published: May 2024

AbstractFrischbetonverbundsysteme (FBVS) stellen eine innovative Bauart im Bereich der Bauwerksabdichtung dar, die eine weite Marktverbreitung in Deutschland gefunden hat. Die abdichtende Wirkung dieser Bauart beruht auf dem flächigen hinterlaufsicheren Verbund von wasserdichten Frischbetonverbundbahnen (FBV‐Bahnen) mit dem Frischbeton. Das DBV‐Merkblatt „Frischbetonverbundsysteme“ in der Fassung September 2023 stellt einen wesentlichen Schritt zu einer geregelten Bauart dar. Es soll sich im Laufe der nächsten Jahre als weitestgehend geschlossenes Regelwerk für diese Bauart, deren Planung und Ausführung sowie mit Vorgaben für eine Qualitätssicherung zu einer anerkannten Regel der Technik (aRdT) entwickeln. Es hebt die Bauart FBVS als additive oder kompensierende Abdichtungsmaßnahme in Kombination mit WU‐Betonkonstruktionen nach der DAfStb‐WU‐Richtlinie auf eine neue Qualitätsstufe. Die Verwendungssicherheit eines FBVS wird somit für die am Bau Beteiligten gegenüber der bisherigen ungeregelten Situation grundlegend verbessert. Das DBV‐Merkblatt kann und soll Grundlage von WU‐Betonbaukonzepten, von Ausschreibungen und Leistungsverzeichnissen sowie von vertraglichen Vereinbarungen sein.
Environmental management accounting for strategic decision‐making: A systematic literature review
Authors: Swalih M. M. , Ram Ronita , Tew Edward 
Published: May 2024

AbstractHeightened environmental concerns have prompted businesses to align with regulatory demands, fostering a need for internal accounting tools aiding managerial decision‐making. While environmental management accounting (EMA) has become pivotal in supporting eco‐efficiency decisions within organizations, a gap persists in comprehending its genuine, proactive implementation for sustainable development in the existing literature. This study investigates why and how EMA is used for strategic decision‐making. A systematic literature review of 89 studies was conducted, and factors influencing EMA usage for strategic decision‐making were identified using the drivers–enablers–outcomes–barriers framework. Three reasons for EMA use in strategic decision‐making were identified: legitimacy, organizational efficiency, and strategic sustainable development. This study highlights the evolving use of EMA within organizations, moving from short‐term applications to recognizing its long‐term potential for strategic sustainable development. It explains the changing motives behind EMA adoption, driven by factors that encourage the use of advanced EMA tools for proactive, long‐term decision‐making in sustainable development. The integration of these tools depends on internal organizational factors like management's environmental responsibility, and proactive leadership commitment to sustainability. By exploring theoretical underpinnings and motivations of enhanced EMA usage, this research contributes to pragmatic approaches in sustainability accounting, illustrating how organizations, initially adopting EMA for legitimacy, recognize its benefits in guiding proactive, solution‐oriented managerial decisions toward strategic sustainable development.
S‐LASSIE: Structure and smoothness enhanced learning from sparse image ensemble for 3D articulated shape reconstruction
Authors: Feng Jingze , He Chong , Wang Guorui , Wang Meili 
Published: May 2024

AbstractIn computer vision, the task of 3D reconstruction from monocular sparse images poses significant challenges, particularly in the field of animal modelling. The diverse morphology of animals, their varied postures, and the variable conditions of image acquisition significantly complicate the task of accurately reconstructing their 3D shape and pose from a monocular image. To address these complexities, we propose S‐LASSIE, a novel technique for 3D reconstruction of quadrupeds from monocular sparse images. It requires only 10–30 images of similar breeds for training. To effectively mitigate depth ambiguities inherent in monocular reconstructions, S‐LASSIE employs a multi‐angle projection loss function. In addition, our approach, which involves fusion and smoothing of bone structures, resolves issues related to disjointed topological structures and uneven connections at junctions, resulting in 3D models with comprehensive topologies and improved visual fidelity. Our extensive experiments on the Pascal‐Part and LASSIE datasets demonstrate significant improvements in keypoint transfer, overall 2D IOU and visual quality, with an average keypoint transfer and overall 2D IOU of 59.6% and 86.3%, respectively, which are superior to existing techniques in the field.
Multifaceted manifestations: A case report of MRSA pneumonia with sepsis, pyelonephritis, and ileus muscle abscess
Authors: Damlakhy Ahmad , Khan Zohaib A. , Abdel‐Qader Anas , Chernyshev Dmitrii , Ross Emily 
Published: May 2024

Key Clinical MessageMethicillin‐resistant staph aureus (MRSA) infections are challenging to treat, and with the emergence of community‐associated MRSA (CA‐MRSA) strains, early consideration of this pathogen in populations without typical risk factors is critical. Here we present a case of CA‐MRSA pneumonia that resulted in Community‐acquired pneumonia (CAP) with septic shock, pyelonephritis, and muscle abscess.
A case report of leukemoid reaction in a child with severe diabetic ketoacidosis (DKA) and cerebral edema: When rarity and complexity meet
Authors: Alfraij Abdulla , Al‐Enazi Naser 
Published: May 2024

Key Clinical MessageIn pediatrics, a leukemoid reaction in severe DKA cases with cerebral edema has never been reported. The fluid management was challenging as it required balancing rates to ensure improvement of the condition while preventing neurological sequelae.AbstractThe combination of diabetic ketoacidosis (DKA), cerebral edema, and leukemoid reaction in pediatrics has never been reported before in the literature. It may lead to significant morbidity and high mortality. Here, we report a case of DKA‐induced cerebral edema associated with severe leukocytosis (WBC 98 × 109/L), which had many challenges in fluid therapy.
HFIP‐Triggered Reduction Radical Coupling of Enamides with Alkynes Towards β‐Keto Alkylamides via H‐Bonding Electron Transfer
Authors: Cheng Xingda , Zhao LuLu , Yan Kelu , Yang Jianjing , Xu Lirong , Wen Jiangwei 
Published: May 2024

AbstractThis study presents metal‐free protocols for the reduction radical coupling of enamides with diverse alkynes, triggered by 1,1,1,3,3,3‐Hexafluoro‐2‐propanol (HFIP), enabling access to β‐keto alkylamides. The established approach demonstrates remarkable efficiency, facile gram‐scale synthesis, and outstanding functional group tolerance. Mechanistic investigations have revealed that the radical reaction is initiated through H‐bonding electron transfer (Hb‐ET) between enamides and HFIP promoted by acids. Notably, the introduction of Hb‐ET protocols for generating radicals represents a highly promising approach in the field of radical chemistry.
Safety of carfentrazone‐ethyl following application of bensulide to creeping bentgrass putting greens
Authors: Raudenbush Zane , Sousek Matt , Thompson Cole S. , Gaussoin Roch 
Published: May 2024

AbstractGolf course superintendents may use bensulide to control annual grassy weeds and carfentrazone‐ethyl (CE) to control silvery‐thread moss (Bryum argenteum Hedw.) in creeping bentgrass putting greens. Creeping bentgrass injury has been reported if CE is applied soon after treatment with bensulide and the safe application interval varies as much as 68 days. Our goal was to improve the precision of recommendations for safe application of CE following bensulide, considering both CE rate and timing. We used a factorial treatment structure that included (1) bensulide or no bensulide, (2) three rates of CE, and (3) nine CE application timings in 2018 and 2019 at locations in Nebraska and Ohio. Because of limited effects in 2018, different CE rates and application timings were used in 2019. Significant creeping bentgrass injury was only observed at 6.7 or 13.4 fl oz acre−1 rates of CE that were applied within 3 days of applying bensulide. Even the 13.4 fl oz acre−1 rate (a 2× rate) of CE did not injure creeping bentgrass when applied at least 7 days after applying bensulide. The 2.0 fl oz acre−1 rate of CE never injured creeping bentgrass, even when applied the same day as bensulide. Cultivar, management, and environmental differences may influence whether subsequent application of bensulide and CE injures creeping bentgrass. Based on the environmental/cultural conditions and cultivars used in this research, golf course superintendents should expect little to no injury when CE is applied at least 1 week after applying bensulide.
Molecular Packing Topology and Interactions to Decipher Mechanical Compliances in Dicyano‐Distyrylbenzene Derivatives
Authors: Ghora Madhubrata , Manna Ranjit Kumar , Park Sang Kyu , Oh Sangyoon , Kim Sung‐Il , Park Soo Young , Gierschner Johannes , Varghese Shinto 
Published: May 2024

AbstractFlexible optoelectronics is the need of the hour as the market moves toward wearable and conformable devices. Crystalline π‐conjugated materials offer high performance as active materials compared to their amorphous counterpart, but they are typically brittle. This poses a significant challenge that needs to be overcome to unfold their potential in optoelectronic devices. Unveiling the molecular packing topology and identifying interaction descriptors that can accommodate strain offers essential guiding principles for developing conjugated materials as active components in flexible optoelectronics. The molecular packing and interaction topology of eight crystal systems of dicyano‐distyrylbenzene derivatives are investigated. Face‐to‐face π‐stacks in an inclined orientation relative to the bending surface can accommodate expansion and compression with minimal molecular motion from their equilibrium positions. This configuration exhibits good compliance towards mechanical strain, while a similar structure with a criss‐cross arrangement capable of distributing applied strain equally in opposite directions enhances the flexibility. Molecular arrangements that cannot reversibly undergo expansion and compression exhibit brittleness. In the isometric CT crystals, the disproportionate strength of the interactions along the bending plane and orthogonal directions makes these materials sustain a moderate bending strain. These results provide an updated explanation for the elastic bending in semiconducting π‐conjugated crystals.
Visible‐Light‐Mediated [2+2] Photocycloadditions of Alkynes
Authors: Zhang Qing‐Bao , Li Feng , Pan Bin , Yu Lei , Yue Xiang‐Guo 
Published: May 2024

AbstractVisible‐light‐mediated [2+2] photocycloaddition reaction can be considered an ideal solution due to its green and sustainable properties, and is one of the most efficient methods to synthesize four‐membered ring motifs. Although research on the [2+2] photocycloaddition of alkynes is challenging because of the diminished reactivity of alkynes, and the more significant ring strain of the products, remarkable achievements have been made in this field. In this article, we highlight the recent advances in visible‐light‐mediated [2+2] photocycloaddition reactions of alkynes, with focus on the reaction mechanism and the late‐stage synthetic applications. Advances in obtaining cyclobutenes, azetines, and oxetene active intermediates continue to be breakthroughs in this fascinating field of research.
Lower intensity therapy with cladribine/low dose cytarabine/venetoclax in older patients with acute myeloid leukemia compares favorably with intensive chemotherapy among patients undergoing allogeneic stem cell transplantation
Authors: Senapati Jayastu , Kantarjian Hagop M. , Bazinet Alexandre , Reville Patrick , Short Nicholas J. , Daver Naval , Borthakur Gautam , Bataller Alex , Jabbour Elias , DiNardo Courtney , Haddad Fadi , Sasaki Koji , Popat Uday , Oran Betul , Alousi Amin M. , Loghavi Sanam , Shpall Elizabeth , Garcia‐Manero Guillermo , Ravandi Farhad , Kadia Tapan M. 
Published: May 2024

AbstractBackgroundAllogeneic stem cell transplantation (SCT) remains the best consolidative modality in most patients with acute myeloid leukemia (AML). Along with factors directly pertaining to SCT, pretransplantation disease control, performance status, and prior treatment‐related complications are important factors that affect posttransplantation survival outcomes.MethodsThe authors compared the survival outcomes of patients ≥60 years of age treated on the phase 2 clinical trial of venetoclax (Ven) added to cladribine (CLAD) and low dose cytarabine (LDAC) alternating with azacitidine (CLAD/LDAC/Ven arm) (NCT03586609) who underwent allogeneic SCT in first remission to a retrospective cohort of patients ≥60 years of age who underwent SCT after intensive chemotherapy. Intensive chemotherapy was defined as the use of cytarabine >1 g/m2 and anthracyclines during induction/consolidation.ResultsThirty‐five patients at median age of 68 years in the CLAD/LDAC/Ven arm were compared to 42 patients at a median age of 62 years in the intensive therapy arm. The 2‐year relapse‐free survival was superior with CLAD/LDAC/Ven versus intensive chemotherapy (88% vs. 65%; p = .03) whereas the 2‐year overall survival (OS) was comparable (84% vs. 70%; p = .14). On a competing event analysis, the 2‐year cumulative incidence of relapse (CIR) was significantly lower with CLAD/LDAC/Ven versus intensive chemotherapy (2.9% vs. 17.2%, Gray’s p = .049) whereas nonrelapse mortality was comparable (16.2% vs. 17.1%; p = .486).ConclusionIn conclusion, treatment with CLAD/LDAC/Ven was associated with favorable outcomes in older patients who underwent subsequent allogeneic SCT. The OS was comparable to that with intensive chemotherapy followed by allogeneic SCT, but the CIR rate was significantly lower.
Enhanced Bioavailability and Reduced Variability of Dasatinib and Sorafenib with a Novel Amorphous Solid Dispersion Technology Platform
Authors: Lennernäs Hans , Brisander Magnus , Liljebris Charlotta , Jesson Gérald , Andersson Per 
Published: May 2024

AbstractDespite clinical advances with protein kinase inhibitors (PKIs), oral administration of many PKIs is associated with highly variable plasma exposure and a narrow therapeutic window. We developed a novel hybrid nanoparticle‐amorphous solid dispersion (ASD) technology platform consisting of an amorphous PKI embedded in a polymer matrix. The technology was used to manufacture immediate‐release formulations of 2 tyrosine kinase inhibitors (TKIs), dasatinib and sorafenib. Our primary objective was to improve the absorption properties and reduce the pharmacokinetic (PK) variability of each TKI. The PKs of XS004 (dasatinib‐ASD, 100 mg tablet) and XS005 (sorafenib‐ASD, 2 × 50 mg capsules) were compared with their crystalline formulated reference drugs (140 mg of dasatinib‐reference and 200 mg of sorafenib‐reference). The in vitro biopharmaceutics of dasatinib‐ASD and XS005‐granulate showed sustained increased solubility in the pH range 1.2‐8.0 compared to their crystalline references. In vivo, XS004 was bioequivalent at a 30% lower dose and showed increased absorption and bioavailability, with 2.1‐4.8 times lower intra‐ and intersubject variability compared to the reference. XS005 had an increased absorption and bioavailability of 45% and 2.2‐2.8 times lower variability, respectively, but it was not bioequivalent at the investigated dose level. Taken together, the formulation platform is suited to generate improved PKI formulations with consistent bioavailability and a reduced pH‐dependent absorption process.
On the Unusual Global Aromaticity of Two Cyclopenta‐Ring‐Fused Oligo(m‐Phenylenes)
Authors: Summa Francesco F. , Zanasi Riccardo , Đorđević Slađana , Radenković Slavko , Monaco Guglielmo 
Published: May 2024

AbstractSome years ago, Jishan Wu reported the synthesis of 8MC and 10MC, two homologues of the cyclopenta‐ring‐fused oligo(m‐phenylene) macrocycles mMC, each behaving as an annulene‐within‐an‐annulene (AWA). This was a surprising result as the AWA behavior is rare. Both molecules have a partial polyradical character, enforced by the quest for restoring some aromatic character of benzene rings. However, that restoration brings back some coupling between the two annulenes. Indeed, we found that the geometry and the magnetically induced currents indicate that, while 8MC does have an AWA character, this is not the case of the larger 10MC. Limitations of the design strategy of AWA molecules should be taken into account in future attempts to prepare novel large coronenes.
Repurposing of drugs against bacterial infections: A pharmacovigilance‐based data mining approach
Authors: Ohra Simran , Sharma Ruchika , Kumar Anoop 
Published: May 2024

AbstractThe World Health Organization (WHO) has published a list of priority pathogens that urgently require research to develop new antibiotics. The main aim of the current study is to identify potential marketed drugs that can be repurposed against bacterial infections. A pharmacovigilance‐based drug repurposing approach was used to identify potential drugs. OpenVigil 2.1 tool was used to query the FDA Adverse Event Reporting System database. The reporting odds ratio (ROR) < 1, ROR95CI upper bound <1, and no. of cases ≥30 were used for filtering and sorting of drugs. Sunburst plot was used to represent drugs in a hierarchical order using the Anatomical Therapeutic Chemical classification. Molecular docking and dynamics were performed using the Maestro and Desmond modules of Schrodinger 2023 software respectively. A total of 40 drugs with different classes were identified based on the pharmacovigilance approach which has antibacterial potential. The molecular docking results have shown energetically favored binding conformation of lisinopril against 3‐deoxy‐manno‐octulosonate cytidylyltransferase, UDP‐2,3‐diacylglucosamine hydrolase, and penicillin‐binding protein 3 (PBP3) of Pseudomonas aeruginosa; olmesartan, atorvastatin against lipoteichoic acids flippase LtaA and rosiglitazone and varenicline against
d‐alanine ligase of Staphylococcus aureus; valsartan against peptidoglycan deacetylase (SpPgdA) and atorvastatin against CDP‐activated ribitol for teichoic acid precursors of Streptococcus pneumoniae. Further, molecular dynamic results have shown the stability of identified drugs in the active site of bacterial targets except lisinopril with PBP3. Lisinopril, olmesartan, atorvastatin, rosiglitazone, varenicline, and valsartan have been identified as potential drugs for repurposing against bacterial infection.