bluuebunny/crossref_metadata_2025_split huggingface dataset:
A nomogram based on conventional and contrast-enhanced ultrasound radiomics for the noninvasively prediction of axillary lymph node metastasis in breast cancer patients
Authors: Sun Chao , Gong Xuantong , Hou Lu , Yang Di , Li Qian , Li Lin , Wang Yong 
Published: May 2024

BackgroundThis study aimed to investigate whether quantitative radiomics features extracted from conventional ultrasound (CUS) and contrast-enhanced ultrasound (CEUS) of primary breast lesions can help noninvasively predict axillary lymph nodes metastasis (ALNM) in breast cancer patients.MethodA total of 111 breast cancer patients with 111 breast lesions were prospectively enrolled. All the included patients received presurgical CUS screening and CEUS examination and were randomly assigned to the training and validation sets at a ratio of 7:3 (n = 78 versus 33). Radiomics features were respectively extracted based on CUS and CEUS using the PyRadiomics package. The max-relevance and min-redundancy (MRMR) and least absolute shrinkage and selection operator (LASSO) analyses were used for feature selection and radiomics score calculation in the training set. The variance inflation factor (VIF) was performed to check the multicollinearity among selected predictors. The best performing model was selected to develop a nomogram using binary logistic regression analysis. The calibration and clinical utility of the nomogram were assessed.ResultsThe model combining CUS reported ALN status, CUS radiomics score (CUS-radscore) and CEUS radiomics score (CEUS-radscore) exhibited the best performance. The areas under the curves (AUC) of our proposed nomogram in the training and external validation sets were 0.845 [95% confidence interval (CI), 0.739-0.950] and 0.901 (95% CI, 0.758-1). The calibration curves and decision curve analysis (DCA) demonstrated the nomogram’s robust consistency and clinical utility.ConclusionsThe established nomogram is a promising prediction tool for noninvasive prediction of ALN status. The radiomics features based on CUS and CEUS can help improve the predictive performance.
Case report: Rapidly progressive desmoid tumor after surgery for esophagogastric junction cancer and slowly progressive primary desmoid tumor: a report of two cases and literature review
Authors: Li Chuan-Ying , Gao Yan-Peng , Jia Ming-Hao , Zhou Yuan , Xu Jia-You 
Published: May 2024

BackgroundDesmoid tumor (DT) is a rare locally aggressive but non-metastatic mesenchymal soft tissue neoplasm that predominantly occurs in the abdominal wall, abdominal cavity, and extremities. Its occurrence in the mesentery is relatively uncommon.Case reportsThis article reports two cases of desmoid tumor treated at the Department of Gastrointestinal Surgery, Weifang People’s Hospital. The first case was a 59-year-old male patient who had previously undergone surgery for esophagogastric junction cancer. Postoperatively, he developed an intra-abdominal mass that rapidly increased in size within three months. The second case was a 60-year-old male patient who incidentally discovered a mass in the left lower abdomen. Both patients underwent surgical treatment, and the postoperative pathological diagnosis was mesenteric desmoid tumor.ConclusionThe treatment of desmoid tumor remains challenging. Simple surgical resection often yields unsatisfactory outcomes, and the efficacy of adjuvant radiotherapy and chemotherapy is also limited. Further research and clinical practice are necessary to improve diagnostic and therapeutic strategies, aiming to enhance patient survival and quality of life.
Lobetyolin protects mice against LPS-induced sepsis by downregulating the production of inflammatory cytokines in macrophage
Authors: Chen Zhonghua , Su Yixin , Ding Jingtong , He Jia , Lai Lihua , Song Yinjing 
Published: May 2024

Introduction: Sepsis is a clinical syndrome characterized by dysregulation of the host immune response due to infection, resulting in life-threatening organ damage. Despite active promotion and implementation of early preventative measures and bundle treatments, sepsis continues to exhibit high morbidity and mortality rates with no optimal pharmacological intervention available. Lobetyolin (LBT), the crucial component of polyacetylenes found in Codonopsis pilosula, has been scientifically proven to possess potent antioxidant and antitumor properties. However, its therapeutic potential for sepsis remains unknown.Methods: The mice received pretreatment with intraperitoneal injections of LBT, followed by injection with lipopolysaccharide (LPS) to induce sepsis. Peripheral blood samples were collected to detect TNF-α, IL-1β, and IL-6 levels. The survival status of different groups was recorded at various time intervals. RNA-Seq was utilized for the analysis of gene expression in peritoneal macrophages treated with LBT or LPS.Results: In this study, we observed a significant increase in the survival rate of mice pretreated with LBT in LPS induced sepsis mouse model. LBT demonstrated a remarkable reduction in the production of IL-6, TNF-α, and IL-1β in the serum, along with mitigated lung and liver tissue damage characterized by reduced inflammatory cell infiltration. Additionally, through RNA-seq analysis coupled with GO and KEGG analysis, it was revealed that LBT effectively suppressed genes associated with bacterium presence, cellular response to lipopolysaccharide stimulation, as well as cytokine-cytokine receptor interaction involving Cxcl10, Tgtp1, Gbp5, Tnf, Il1b and IRF7 specifically within macrophages. We also confirmed that LBT significantly downregulates the expression of IL-6, TNF-α, and IL-1β in macrophage activation induced by LPS.Discussion: Therefore, our findings demonstrated that LBT effectively inhibits the production of inflammatory cytokines (IL-6, TNF-α, and IL-1β) and mitigates sepsis induced by LPS through modulating macrophages' ability to generate these cytokines. These results suggest that LBT holds promise as a potential therapeutic agent for sepsis treatment.
Hype or hope? Ketamine for the treatment of depression: results from the application of deep learning to Twitter posts from 2010 to 2023
Authors: Ng Qin Xiang , Lim Yu Liang , Ong Clarence , New Silas , Fam Johnson , Liew Tau Ming 
Published: May 2024

ObjectiveTo investigate societal perceptions of ketamine’s use in depression therapy by analysing Twitter posts from January 1, 2010 to April 1, 2023.MethodsUsing Twitter as the social media platform of choice, and employing search terms based on (depression OR depressed OR depressive) AND (ketamine OR esketamine OR Spravato), we collected English-language tweets from January 1, 2010, to April 1, 2023. Using unsupervised machine learning and natural language processing (NLP) techniques, including Bidirectional Encoder Representations from Transformers (BERT) and BERTopic, the study identified prevalent topics surrounding public chatter around the use of ketamine in depression treatment. Manual thematic analyses further refined these topics into themes.ResultsOut of an initial dataset of 99,405 tweets, after removing duplicate tweets, re-tweets and tweets posted by organizations over Twitter, 18,899 unique tweets from presumably individual users were analysed. Analysis of temporal trends revealed a shift in public attitudes, particularly after the United States Food and Drug Administration (FDA)’s 2019 approval of ketamine for depression. Three major themes emerged: a changing regulatory landscape, cautious optimism, and personal experiences with the drug. There was an initial spike in discussions post-FDA approval in 2019. Thereafter, cautious optimism (Theme 2) decreased among the general public, with more personal accounts (Theme 3) highlighting the potential benefits for some treatment-resistant patients. Limitations of the study include Twitter’s inherent biases towards younger, English-speaking demographics.ConclusionIn summary, the public’s multifaceted perception leans towards a hopeful stance on ketamine’s therapeutic potential for depression.
Factors associated with the use of annual health checkups in Thailand: evidence from a national cross-sectional health and welfare survey
Authors: Paek Seung Chun , Zhang Ning Jackie 
Published: May 2024

IntroductionThailand has provided free annual health checkups (AHC) since universal health coverage began in 2002. However, evidence regarding the equitable use of AHC is scarce. Thus, this study explored factors associated with the use of AHC in Thailand.MethodsA cross-sectional study was conducted using data from the national 2015 Health and Welfare Survey. Respondents aged 15 years or above (n = 57,343) were selected as the study sample. Descriptive statistical analysis and multivariable binary logistic regression were conducted to examine the association between the use of AHC and factors selected on the basis on Andersen’s Behavioral Model of Access to Medical Care.ResultsAmong the study sample, approximately 4.9% (n = 2,815) had used AHC during the past year. Regarding predisposing factors, the use of AHC was positively related to age (e.g., over 61 vs. 15–30: AOR = 2.90 [95% CI = 2.40–3.52], p &lt; 0.001) and female sex (AOR = 1.23 [95% CI = 1.12–1.35] p &lt; 0.001). For enabling factors, the AHC use was positively associated with income (e.g., Q4 vs. Q1: AOR = 1.98 [95% CI = 1.75–2.25], p &lt; 0.001), education (e.g., high vs. low: AOR = 3.11 [95% CI = 2.75–3.51], p &lt; 0.001), being married (e.g., vs. single: AOR = 1.27 [95% CI = 1.11–1.46], p &lt; 0.001), and urban residency (AOR = 1.12 [95% CI = 1.04–1.22], p = 0.006). For need-for-care factors, the AHC use was positively related to chronic disease (AOR = 1.26 [95% CI = 1.15–1.38], p &lt; 0.001), non-smoking (e.g., vs. daily: AOR = 1.18 [95% CI = 1.03–1.36], p = 0.015), non-drinking (e.g., vs. 3–4 times per week: AOR = 1.26 [95% CI = 1.04–1.53], p = 0.016), and vegetable consumption (e.g., over 5 ladles vs. below 1 ladle: AOR = 1.86 [95% CI = 1.50–2.31], p &lt; 0.001).ConclusionThe results indicate that health awareness could play a significant role in the use of AHC. Individuals with high socioeconomic status (e.g., high-income people) and those with low-risk health behaviors (e.g., non-smokers) generally have a high interest in health and well-being. This may have been the primary reason for the high use of AHC among these groups. Thus, the government should continue to promote the public’s health awareness through various public campaigns and education programs to increase the use of AHC.
Novel Tick-Borne Anaplasmataceae Genotypes in Tropical Birds from the Brazilian Pantanal Wetland
Authors: Alabí Córdova Amir Salvador , Fecchio Alan , Calchi Ana Cláudia , Dias Clara Morato , Mongruel Anna Claudia Baumel , das Neves Lorena Freitas , Lee Daniel Antonio Braga , Machado Rosangela Zacarias , André Marcos Rogério 
Published: May 2024

Despite numerous reports of Anaplasmataceae agents in mammals worldwide, few studies have investigated their occurrence in birds. The present study aimed to investigate the occurrence and molecular identity of Anaplasmataceae agents in birds from the Pantanal wetland, Brazil. Blood samples were collected from 93 different species. After DNA extraction, samples positive for the avian β-actin gene were subjected to both a multiplex quantitative real-time (q)PCR for Anaplasma and Ehrlichia targeting the groEL gene and to a conventional PCR for Anaplasmataceae agents targeting the 16S rRNA gene. As a result, 37 (7.4%) birds were positive for Anaplasma spp. and 4 (0.8%) for Ehrlichia spp. in the qPCR assay; additionally, 13 (2.6%) were positive for Anaplasmataceae agents in the PCR targeting the 16S rRNA gene. The Ehrlichia 16S rRNA sequences detected in Arundinicola leucocephala, Ramphocelus carbo, and Elaenia albiceps were positioned closely to Ehrlichia sp. Magellanica. Ehrlichia dsb sequences detected in Agelasticus cyanopus and Basileuterus flaveolus grouped with Ehrlichia minasensis. The 16S rRNA genotypes detected in Crax fasciolata, Pitangus sulphuratus and Furnarius leucopus grouped with Candidatus Allocryptoplasma. The 23S-5S genotypes detected in C. fasciolata, Basileuterus flaveolus, and Saltator coerulescens were related to Anaplasma phagocytophilum. In conclusion, novel genotypes of Anaplasma, Ehrlichia, and Candidatus Allocryptoplasma were detected in birds from the Pantanal wetland.
Insentif Pajak PMK 86/2020, Norma Subjektif, Modernisasi Sistem Perpajakan Dan Kepatuhan Wajib Pajak UMKM
Authors: Yobelia Gabrielle Merry Yobelia , Kristanto Septian Bayu 
Published: May 2024

The purpose of this study is to examie the effect of PMK 86/ 2020 tax incentives, subjective norms, and modernization of the tax system on MSME taxpayer compliance during the COVID-19 pandemic in Tangerang City. From 105 samples in the age category and NPWP ownership category, it have been found that: 1) the PMK 86/ 2020 tax incentives has a positive effect on the compliance level of MSME taxpayers in Tangerang City during the COVID-19 pandemic, 2) subjective norms has a negative effect on the level of compliance of MSME taxpayers in Tangerang City during the COVID-19 pandemic, and 3) the modernization of the taxation system has a positive effect on the level of taxpayer compliance in Tangerang City during the COVID-19 pandemic.

Keywords: Tax incentives, subjective norms, modernization of the tax system, and taxpayer compliance
Whistleblowing Intention: Suatu Tinjauan Theory of Planned Behavior
Authors: Yuniarwati Yuniarwati , Ardana I Cenik , Prima Dewi Sofia 
Published: May 2024

Entering the 21st century, there has been an increase in white-collar crime both in quantity and quality in various parts of the world. White-collar crime is synonymous with various frauds committed by business and government professionals characterized by fraud, concealment, or breach of trust and is not dependent on the application of threats of violence or physical force. The internal control system, which has been very popular and is believed by many parties to prevent various violations, is a blunt weapon to expose various forms of certain white-collar crimes. This is because certain types of white collar crimes often involve the top leaders of an organization that has high authority in the organization, even though the person functions as a guardian of the rules in the internal control system that is applied. Bearing in mind the weaknesses of the internal control system and the increasing white collar crime, various countries and business associations have made various prevention efforts and have increasingly increased the demand for a good governance system. The violation reporting mechanism can be one of the elements that can be relied upon in a good governance system. It is recognized that whistleblowers have given a very important role in exposing various major crime scandals. The population in this study are employees of private companies located in Jakarta. The research data was obtained from distributing questionnaires directly to respondents or via email. The research sample is non random selected in convenience. The results showed subjective norms had a positive and significant effect on intentions of reporting violations, while attitudes and behavioral control perceived positive but not significant effect on intentions of reporting violations.

Keywords: intentions of reporting violations, attitudes, subjective norms, perceived behavioral control.
Dampak Corporate Social Responsibility pada Kinerja Keuangan yang Dimoderasi Ukuran Perusahaan (Studi Empiris Pada Perusahaan LQ45 Yang Terdaftar di Bursa Efek Indonesia Tahun (2021)
Authors: Dasmaran Verliani , Fika Fauziah 
Published: May 2024

This study aims to obtain empirical evidence regarding the Effect of Corporate Social Responsibility on Financial Performance with Company Size as a Moderating Variable listed on the Indonesia Stock Exchange in 2021. The population in this study are LQ45 companies listed on the Indonesia Stock Exchange. The number of research samples is 45 companies. The data analysis technique used is saturated sampling technique, with regression, correlation and determination tests. The results of the study prove that Corporate Social Responsibility has a positive effect on Financial Performance, this is because the complete disclosure of Corporate Social Responsibility activities can convince investors or stakeholders in carrying out their responsibilities. While company size can moderate the effect of Corporate Social Responsibility on Financial Performance, this proves company size can increase the trust of external parties in carrying out corporate responsibility

Keywords: corporate social responsibility. company size, financial performance
Evaluación de las Propiedades Químicas y Funcionales, Actividad Antioxidante y Cuantificación de Flavonoides de la Pulpa de Yaca Liofilizada (Artocarpus Heterophyllus)
Authors: Moreno Zaragoza Josue , Moctezuma García Gonzalo , Gama Gálvez María de los Ángeles , Gabriel Salmerón Beatriz , Catalán Cardeño Yolanda 
Published: May 2024

En el país al año se producen aproximadamente 30,000 ton de yaca, de las cuales el 90 % son del estado de Nayarit. Es el fruto más grande del mundo, además es una fuente rica en carbohidratos, proteína, compuestos antioxidantes como las vitaminas A y B. Sin embargo, es poco el aprovechamiento de todas sus propiedades, debido a que es un fruto traspatio, gran parte de esto se debe a la falta información científica. Debido a la problemática de salud pública que hay en obesidad, diabetes y enfermedades cancerígenas. Existe la gran necesidad de incrementar la ingesta de los alimentos nutracéuticos, por lo que abre un sector de investigación donde se requiere caracterizar nuevas alternativas de alimentos que puedan además de aportar nutrientes, dar un control y prevención de enfermedades crónico-degenerativas. El objetivo del trabajo fue evaluar las propiedades químicas, funcionales y actividad antioxidante de la pulpa de yaca liofilizada. Para obtener mayor rendimiento de los compuestos antioxidantes se optó por usar liofilización para el secado de la pulpa. Se destacó un aumento del 50.21 % en carbohidratos totales y del 11 % en lípidos con respecto a estudios publicados por otros autores. Se cuantificaron los (ácidos urónicos=103.2098 mg Equivalentes de Ácido Galacturónico/g b.s., taninos condensados=4.4154 mg Equivalentes de Catequina/g b.s. y fenoles totales=58.6910 µg Equivalentes de Ácido Gálico/ g b.s.), se evaluó la capacidad antioxidante por los ensayos DPPH• (59.74 % de inhibición) y ABTS•+ (67 % de inhibición) para el método por ABTS•+ se analizaron los factores tiempo-temperatura vs disolvente donde las condiciones óptimas de extracción con metanol fueron (70º C; 12 min) y con agua (60 ºC; 5min), el contenido de flavonoides fue de 0.100 mg Equivalentes de Quercetina / g b.s. A partir de lo anterior, se considera que la pulpa de yaca contiene los compuestos característicos de un alimento nutracéutico para poder ser aprovechados en la industria alimentaria en darle valor agregado al fruto y poder potenciar su comercialización en México.
Phosphorus Enrichment by ONe Novae in the Galaxy
Authors: Bekki Kenji , Tsujimoto Takuji 
Published: May 2024

Abstract
Recent observations have shown that [P/Fe] in the Galactic stars decreases with increasing [Fe/H] for [Fe/H] ≳ − 1 whereas it is almost subsolar for [Fe/H] ≲ −2. These [P/Fe] trends with [Fe/H] have not been well reproduced by previous theoretical models incorporating phosphorus (P) enrichment only by core collapse supernoave. We here show, for the first time, that the trends can be naturally explained by our new models incorporating P enrichment by oxygen–neon (ONe) novae, which occur at the surface of massive white dwarfs whose masses are larger than 1.25M
⊙ with a metallicity-dependence rate. We also show that the observations can be better reproduced by the models by assuming that (i) the total mass of gaseous ejecta per ONe nova (M
ej) is as high as 4 × 10−5
M
⊙ and (ii) the number of such novae per unit mass (N
ONe) is as large as 0.01 at [Fe/H] ≈ −3. The assumed M
ej is consistent with observations, and the high N
ONe is expected from recent theoretical models for ONe nova fractions. We predict that (i) [P/Fe] increases with increasing [Fe/H] for −2 ≲ [Fe/H] ≲ −1 and (ii) [P/Fe] and [Cl/Fe] trends with [Fe/H] are very similar to each other due to very large yields of P and Cl from ONe novae. It is thus worthwhile for future observations to assess the validity of the proposed P enrichment by ONe novae by confirming or ruling out these two predictions.
The Sensitivity of NEO Surveyor to Low-perihelion Asteroids
Authors: Masiero Joseph R. , Kwon Yuna G. , Dahlen Dar W. , Masci Frank J. , Mainzer Amy K. 
Published: May 2024

Abstract
Asteroids with low orbital perihelion distances experience extreme heating from the Sun that can modify their surfaces and trigger nontypical activity mechanisms. These objects are generally difficult to observe from ground-based telescopes due to their frequent proximity to the Sun. The Near-Earth Object (NEO) Surveyor mission, however, will regularly survey down to solar elongations of 45° and is well suited for the detection and characterization of low-perihelion asteroids. Here, we use the survey simulation software tools developed for mission verification to explore the expected sensitivity of NEO Surveyor to these objects. We find that NEO Surveyor is expected to be >90% complete for near-Sun objects larger than D ∼ 300 m. Additionally, if the asteroid (3200) Phaethon underwent a disruption event in the past to form the Geminid meteor stream, Surveyor will be >90% complete to any fragments larger than D ∼ 200 m. For probable disruption models, NEO Surveyor would be expected to detect dozens of objects on Phaethon-like orbits, compared to a predicted background population of only a handful of asteroids, setting strong constraints on the likelihood of this scenario.
Energy efficiency assessment of wireless system exploiting multiple reconfigurable intelligent surfaces with hardware impairments
Authors: Vinh Nguyen Van 
Published: May 2024

AbstractThis article explores a practical scenario with hardware impairments (HIs) in a multireconfigurable intelligent surface (RIS) assisted wireless system. This approach is based on a mathematical analysis of the performance of the HI‐RIS system. To this end, a closed‐form expression of the energy efficiency (EE) and its asymptotic behavior, particularly in regions with high transmit power, are derived. Next, an analysis was conducted to compare the EE of the HI‐RIS system with those of relevant systems: the ideal hardware (ID)‐RIS system, HI‐point‐to‐point (P2P) system (without RISs), and ID‐P2P system (without RISs). The numerical findings unequivocally demonstrate that the incorporation of RISs substantially enhances the EE of the HI‐RIS system, particularly at high transmit rates. However, at low transmit rates, the EE of the HI‐RIS system less than that of the HI‐P2P system. This trend is also reflected in the EEs of the ID‐RIS and ID‐P2P systems. Moreover, the significant impact of HI on the EEs of the HI‐RIS and HI‐P2P systems is analyzed. The effects of crucial system parameters, such as the number of reflecting elements, frequencies of WiFi networks, and fading order, are comprehensively determined to provide insights into the behaviors of the HI‐RIS system. The outage probability and throughput behaviors of the HI‐RIS system are also evaluated to comprehensively analyze of the benefits of RISs and the effects of HI. Finally, the accuracy of the derived expressions was verified using Monte Carlo simulations.