bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief communication: Dental development timing in captivePan paniscuswith comparisons toPan troglodytes
Authors: Bolter Debra R. , Zihlman Adrienne L. 
Published: May 2011

AbstractDental eruption provides markers of growth and is one component of a chimpanzee's physical development. Dental markers help characterize transitions between life stages, e.g., infant to juvenile. Most of what we know about the timing of development in chimpanzees derives fromPan troglodytes.Much less is known about the sister species,Pan paniscus, with few in captivity and a restricted wild range in central Africa. Here we report on the dental eruption timing for female captiveP. paniscus(n= 5) from the Milwaukee and San Diego Zoos whose ages are known and range from birth to age 8.54 years. Some observations were recorded in zoo records on the gingiva during life; others were made at death on the gingiva and on the skeleton. At birth,P. paniscusinfants have no teeth emerged. By 0.83 years, all but the deciduous second molars (dm2) (when both upper and lower dentitions are referenced collectively, no super or subscript notation is used) and canines (dc) are emerged. For permanent teeth, results show a sequence polymorphism for an early P4 eruption, not previously described forP. paniscus. Comparisons betweenP. paniscusandP. troglodytesdocument absolute timing differences of emergence in upper second incisors (I2), and upper and lower canines (C) and third molars (M3). The genusPanencompasses variability in growth not previously recognized. These preliminary data suggest that physical growth in captiveP. paniscusmay be accelerated, a general pattern found in captiveP. troglodytes. Am J Phys Anthropol, 2011. © 2011 Wiley‐Liss, Inc.
Feeding behavior and nutrient intake in spiny forest‐dwelling ring‐tailed lemurs (Lemur catta) during early gestation and early to mid‐lactation periods: Compensating in a harsh environment
Authors: Gould Lisa , Power Michael L. , Ellwanger Nicholas , Rambeloarivony Hajamanitra 
Published: May 2011

AbstractStrong resource seasonality in Madagascar has led to the evolution of female feeding priority and weaning synchrony in most lemur species. For these taxa, pregnancy/early lactation periods coincide with low food availability, and weaning of infants is timed with increased resources at the onset of the rainy season. Reproductive females experience high metabolic requirements, which they must accommodate, particularly when food resources are scarce. Female ring‐tailed lemurs (Lemur catta) residing in spiny forest habitat must deal with resource scarcity, high temperatures (∼36–40°C) and little shade in early to mid‐lactation periods. Considered “income breeders,” these females must use resources obtained from the environment instead of relying on fat stores; thus, we expected they would differ from same‐sized males in time spent on feeding and in the intake of food and nutrients. We investigated these variables in two groups (N = 11 and 12) of Lemur catta residing in spiny forest habitat during early gestation and early to mid‐lactation periods. Focal animal data and food plant samples were collected, and plants were analyzed for protein, kcal, and fiber. We found no sex differences for any feeding or nutrient intake variable for the top five food species consumed. Females in early gestation spent more time feeding compared with early/mid‐lactation. Physiological compensation for spiny forest‐dwelling females may be tied to greater time spent resting compared with gallery forest conspecifics, consuming foods high in protein, calories, and water, reduced home range defense in a sparsely populated habitat, and for Lemur catta females in general, production of relatively dilute milk compared with many strepsirrhines. Am J Phys Anthropol, 2011. © 2011 Wiley‐Liss, Inc.
Improved Assessment of Ex Vivo Brainstem Neuroanatomy With High‐Resolution MRI and DTI at 7 Tesla
Authors: Soria Guadalupe , De Notaris Matteo , Tudela Raúl , Blasco Gerard , Puig Josep , Planas Anna M. , Pedraza Salvador , Prats‐Galino Alberto 
Published: May 2011

AbstractThe aim of the present work was to provide the topography of the main gray nuclei and white matter tracts of the human brainstem at 7 Tesla (7 T) high‐field magnetic resonance imaging (MRI) using structural imaging (T1) and diffusion tensor imaging (DTI). Both imaging techniques represent a new field of increasing interest for its potential neuroanatomic and neuropathologic value. Brainstems were obtained postmortem from human donors, fixated by intracarotid perfusion of 10% neutral buffered formalin, and scanned in a Bruker BioSpec 7 T horizontal scanner. 3D‐data sets were acquired using the modified driven equilibrium Fourier transform (MDEFT) sequence and Spin Echo‐DTI (SE‐DTI) sequence was used for DTI acquisition. High‐resolution structural MRI and DTI of the human brainstem acquired postmortem reveals its basic cyto‐ and myeloar‐chitectonic organization, only visualized to this moment by histological techniques and higher magnetic field strengths. Brainstem structures that are usually not observed with lower magnetic fields were now topographically identified at midbrain, pons, and medullar levels. The application of high‐resolution structural MRI will contribute to precisely determine the extension and topography of brain lesions. Indeed, the current findings will be useful to interpret future high‐resolution in vivo MRI studies in living humans. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
Intracellular Trafficking of Histone Deacetylase 4 Regulates Long‐Term Memory Formation
Authors: Wang Wen‐Han , Cheng Li‐Cheng , Pan Fei‐Yan , Xue Bin , Wang Da‐Yong , Chen Zhong , Li Chao‐Jun 
Published: May 2011

AbstractHistone acetylation is important for gene transcription, which is controlled by the balance between two kinds of opposing enzymes: histone acetyltransferases and histone deacetylases (HDACs). HDACs repress gene transcription by decreasing histone acetylation levels. Our hypothesis was that shuttling of Class II HDACs, such as HDAC4, between the nucleus and cytoplasm is critical for its function. We constructed mutants of mammalian HDAC4 that had different cellular locations and checked their function during memory formation using Caenorhabditis elegans as a model. The deletion of hda4, a homolog of HDAC4, was able to enhance learning and long‐term memory (LTM) in a thermotaxis model. Transgenic experiments showed that mammalian wild‐type HDAC4 rescued the phenotype of hda4‐deleted worms but impaired LTM formation in wild‐type worms. The cytosol‐localized HDAC4 mutant was not able to alter the phenotype of knock‐out worms but led to enhanced LTM formation in wild‐type worms similar to hda4‐deletion mutants. Constitutive nuclear localization of HDAC4 rescued the phenotype of deletion worms similar to wild‐type HDAC4 but had no effect on wild‐type worms. These results support our hypothesis that HDAC4′s biological function is regulated by its intracellular distribution. Anat Rec, 2011. © 2011 Wiley‐Liss, Inc.
Functional characterization and immunolocalization of odorant binding protein 1 in the lucerne plant bug, Adelphocoris lineolatus (GOEZE)
Authors: Gu Shao‐Hua , Wang Wei‐Xuan , Wang Gui‐Rong , Zhang Xue‐Ying , Guo Yu‐Yuan , Zhang Ziding , Zhou Jing‐Jiang , Zhang Yong‐Jun 
Published: May 2011

AbstractIn the insect phylum, the relationships between individuals and their environment are often modulated by chemical communication. Odorant binding proteins (OBPs) are widely and robustly expressed in insect olfactory organs and play a key role in chemosensing and transporting hydrophobic odorants across the sensillum lymph to the olfactory receptor neuron. In this study, a novel OBP gene (AlinOBP1) in the lucerne plant bug, Adelphocoris lineolatus was identified, cloned and expressed. Real‐time PCR results indicated that the expression level of AlinOBP1 gene differed in each developmental stage (from first instar to adult) and was predominantly expressed in the antennae of adults. The expression level of AlinOBP1 was 1.91 times higher in male antennae than in female antennae. The binding properties of AlinOBP1 with 114 odorants were measured using a fluorescence probe, N‐phenyl‐1‐naphthylamine (1‐NPN), with fluorescence competitive binding. The results revealed that AlinOBP1 exhibits high binding abilities with two major putative pheromone components, ethyl butyrate and trans‐2‐hexenyl butyrate. In addition, it was observed that six volatiles released from cotton, octanal, nonanal, decanal, 2‐ethyl‐1‐hexanol, β‐caryophyllene and β‐ionone also bind to AlinOBP1. Immunocytochemistry analysis showed that AlinOBP1 was expressed in the sensillum lymph of sensilla trichodica and sensilla basiconca. Our results demonstrate that AlinOBP1 may function as a carrier in the chemoperception of the lucerne plant bug. © 2011 Wiley Periodicals, Inc.
Hepatectomy for recurrent colorectal liver metastases after radiofrequency ablation
Authors: Brouquet A , Vauthey J-N , Badgwell B D , Loyer E M , Kaur H , Curley S A , Abdalla E K 
Published: May 2011

Abstract

Background
The results of surgery for recurrent colorectal liver metastases (CLM) after radiofrequency ablation (RFA) have not been evaluated.

Methods
From 1993 to 2009, data on patients who underwent resection or RFA for recurrent CLM were collected prospectively. Inclusion criteria for this study were RFA as initial treatment for CLM and resection of recurrent CLM after RFA. Postoperative results and oncological outcomes were analysed.

Results
Twenty-eight patients (median number of tumours 1 (1–3), median size 2·8 (2·0–4·0) cm) met the inclusion criteria. Of these, 22 had recurrence at the site of RFA only, two developed new lesions, whereas four had both recurrent and de novo metastases. At the time of resection, patients had a median of 1 (1–13) CLM with a median maximum tumour diameter of 5·0 (1·8–11·0) cm, significantly larger than at the time of RFA (P = 0·021). Ninety-day postoperative morbidity and mortality rates were 46 per cent (13 of 28) and 7 per cent (2 of 28) respectively. After a median follow-up of 35 (0–70) months, 3-year overall and disease-free survival rates calculated by Kaplan–Meier analysis were 60 and 29 per cent respectively. Plasma carcinoembryonic antigen level over 5 ng/ml at the time of resection and a rectal primary tumour were associated with worse survival (P = 0·041 and P = 0·021 respectively).

Conclusion
Resection for recurrence after RFA is associated with significant morbidity and modest long-term benefit.
Bilateral coronary ostial stenoses post‐bentall procedure causing hemodynamic collapse and requiring mechanical assist device placement: Successful intervention using the Szabo technique
Authors: Kovacic Jason C. , Sharma Samin K. , Kini Annapoorna S. 
Published: May 2011

AbstractDespite surgical advances, the Bentall procedure still carries a 2–6% rate of acute complications involving the coronary vessels, including ostial stenoses, kinking or pseudoaneurysm formation. We report an unusual case of a patient who developed acute cardiogenic shock within hours following a Bentall procedure, requiring urgent mechanical assist device support. Coronary angiography revealed significant bilateral coronary ostial stenoses; suggesting global cardiac hypoperfusion as the cause for this acute hemodynamic collapse. Given the disturbed coronary anatomy, the novel Szabo technique was used to accurately position and deploy an ostial right and then an ostial left main coronary stent, with excellent angiographic results. We conclude that even in situations with altered coronary anatomy, the Szabo technique should be considered for any patient requiring precise aorto‐ostial stent placement. © 2011 Wiley‐Liss, Inc.
Subintimal guidewire tracking during successful percutaneous therapy for chronic coronary total occlusions: Insights from an intravascular ultrasound analysis
Authors: Muhammad Kamran I. , Lombardi William L. , Christofferson Ryan , Whitlow Patrick L. 
Published: May 2011

AbstractObjectives: We sought to determine the frequency of subintimal guidewire tracking during successful percutaneous coronary intervention (PCI) for chronic coronary total occlusions (CTOs) and to better understand the procedural implications of this event. Background: Successful PCI for chronic CTO is associated with improved outcomes in patients with ischemia. While subintimal guidewire tracking resulting in failure to cross is recognized as the major mode of failure for CTO PCI, the implications of subintimal guidewire tracking during successful CTO PCI are unknown. Methods: Between March 2007 and October 2007, 26 consecutive patients, each with one de‐novo CTO lesion successfully crossed with a guidewire were included in the analysis. Intravascular ultrasound (IVUS) was performed in each CTO vessel after guidewire crossing. Cases were classified as having definite subintimal wire tracking or no clear evidence of subintimal wire tracking based on analysis of IVUS images. Results: Subintimal wire tracking occurred in 45% of cases. In cases where subintimal wire tracking was present, a previous attempt at CTO PCI was more common (42% vs. 7%, P ≤ 0.05). Subintimal wire tracking was also associated with significantly longer final mean stent length (71 vs. 50 mm), procedure time (122 vs. 69 min), fluoroscopy time (47 vs. 22 min), and contrast dose (300 vs. 199 mL, P ≤ 0.05 for all). There was one perforation in the subintimal group which was successfully treated with stent placement. Conclusions: Subintimal wire tracking occurs frequently during successful PCI for CTO and is associated with increased lesion and procedural complexity.© 2011 Wiley Periodicals, Inc
Retrograde recanalization of chronic total occlusions from the transradial approach; Early canadian experience
Authors: Rinfret Stéphane , Joyal Dominique , Nguyen Can Manh , Bagur Rodrigo , Hui William , Leung Raymond , Larose Eric , Love Michael P. , Mansour Samer 
Published: May 2011

AbstractBackground: Retrograde approach for chronic total occlusions (CTO) improves recanalization success rates. Eight French (Fr) catheters and the femoral approach are advocated. Objectives: Evaluate whether transradial operators can achieve similar success rates using smaller catheters. Methods: This is a single‐operator series of 42 consecutive cases performed between January and December 2010, including 13 while demonstrating CTO recanalization. Patients were referred because of complexity of the CTO or after failed attempt. Results: Most frequent indications for recanalization were CCS 3–4 angina (52%) and CCS 1–2 in 21%. Eighteen (43%) patients underwent previous failed attempts. CTO was in the right coronary in 74%, left anterior descending in 24%, and a left main in 1. Most lesions (88%) were ≥20 mm long and 52% were calcified. We used septal collateral channels (CC) in 33 (79%), epicardial CC in 8 (20%), and a saphenous vein graft in one case. Radial access was used in all patients and was bilateral in 37 (88%). Five cases required one radial and one femoral access. Six French guides were used in 91% for the retrograde side and 71% for the antegrade side. Otherwise, 7 Fr guides were used. The Corsair® was used in 38 (90%). Procedural success was achieved in 37 (88%), mostly using reverse controlled antegrade–retrograde tracking (60%) or retrograde crossing (29%). The average <24‐h Hb drop was 0.75 ± 0.84 g/dl. No in‐hospital major cardiac events occurred. Conclusion: Transradial retrograde CTO recanalization is feasible, safe, and still associated with high success rates despite the use of smaller guide catheters. © 2011 Wiley‐Liss, Inc.
Two‐year follow‐up of the genous™ endothelial progenitor cell capturing stent versus the taxus liberté stent in patients with De Novo coronary artery lesions with a high‐risk of restenosis
Authors: Beijk Marcel A.M. , Klomp Margo , van Geloven Nan , Koch Karel T. , Henriques José P.S. , Baan Jan , Vis Marije M. , Tijssen Jan G.P. , Piek Jan J. , de Winter Robbert J. 
Published: May 2011

AbstractBackground:In the prospective randomized TRIAS pilot study, the bio‐engineered Genous™ endothelial progenitor cell capturing stent was compared with the Taxus Liberté™ SR paclitaxel‐eluting stent. At 1 yr, a statistically nonsignificant difference in the rates of target vessel failure (cardiac death, myocardial infarction, or target vessel revascularization) was observed. We have evaluated the safety and efficacy up to 2 yr.Methods:A total of 193 patients with de novo coronary artery lesions carrying a high risk of restenosis were randomized to a Genous stent versus a Taxus stent. Dual antiplatelet therapy was prescribed for ≥1 month after Genous stent implantation and for ≥6 months after a Taxus stent.Results:Between 1 and 2 yr, patients treated with the Genous stent tended to have fewer episodes of target lesion revascularization (2.0% versus 5.3%), but nearly similar rates of cardiac death (1.0% versus 0%), myocardial infarction (0% versus 1.1%), and stent thrombosis (0% versus 1.1%) when compared with the Taxus stent. As a result, at 2‐yr follow‐up treatment with the Genous stent compared with the Taxus stent resulted in a nonsignificant difference in target vessel failure (TVR) (20.4% versus 15.8%; risk difference 4.6%, 95% CI −6.2–15.5%). No stent thrombosis was observed in the Genous group compared to five cases (in four patients) in the Taxus group, resulting in a difference as compared with the Taxus stent (risk difference −4.2%; 95%CI −8.2% to −0.2%).Conclusions:In the TRIAS pilot study, treatment of coronary artery lesions carrying a high risk of restenosis with the Genous compared with the Taxus stent resulted in a nonsignificant difference of TVR at 2‐yr follow‐up, with convergence of the Kaplan‐Meier curves between 1 and 2 yr. Stent thrombosis was only observed after Taxus stent implantation. © 2011 Wiley‐Liss, Inc.
Prevention of contrast‐induced acute kidney injury in patients with stable chronic renal disease undergoing elective percutaneous coronary and peripheral interventions: Randomized comparison of two preventive strategies
Authors: Hafiz Abdul Moiz , Jan M. Fuad , Mori Naoyo , Shaikh Fareed , Wallach Jeffrey , Bajwa Tanvir , Allaqaband Suhail 
Published: May 2011

AbstractObjective: We compared use of intravenous (IV) normal saline (NS) to sodium bicarbonate (NaHCO3) with or without oral N‐acetylcysteine (NAC) for prevention of contrast‐induced acute kidney injury (CI‐AKI). Background: CI‐AKI is associated with significant adverse clinical events. Use of NAC has produced variable results. Recently, intravenous hydration with NaHCO3 for CI‐AKI prophylaxis has been adopted as standard treatment for patients with stable chronic renal disease undergoing catheterization procedures. Methods: We prospectively enrolled 320 patients with baseline renal insufficiency scheduled to undergo catheterization. Patients were randomly assigned to receive either IV NS ± NAC (n = 161) or IV dextrose 5% in water containing 154 mEq/l of NaHCO3 ± NAC (n = 159). IV NS was administered at 1 ml/kg body weight for 12 hr preprocedure and 12 more hr postprocedure. IV NaHCO3 was administered at 3 ml/kg body weight for 1 hr preprocedure followed by 1 ml/kg body weight postprocedure. A 1,200 mg oral dose of NAC was given 2–12 hr preprocedure and 6–12 hr postprocedure in 50% of patients in each study arm. CI‐AKI was defined as an increase of >0.5 mg/dl or >25% above baseline creatinine. Results: Overall incidence of CI‐AKI was 10.3%. There was no significant difference in incidence among the two groups (NS ± NAC 11.8% vs. NaHCO3 ± NAC 8.8%, p = ns). Incidence of CI‐AKI increased with increasing age (p = 0.001), contrast agent use >3 ml/kg body weight (p = 0.038) and diuretic use (p = 0.005). Conclusion: Incidence of CI‐AKI was no different in the NaHCO3 group compared to NS group, and NAC did not reduce CI‐AKI in the two study arms. © 2011 Wiley Periodicals, Inc.
Mid‐term follow up of perventricular device closure of muscular ventricular septal defects
Authors: Bendaly Edgard A. , Hoyer Mark H. , Breinholt John P. 
Published: May 2011

AbstractBackground: Surgical and transcatheter management of muscular ventricular septal defects (MVSD) have independent drawbacks. Hybrid procedures are becoming increasingly utilized to manage congenital cardiac lesions including MVSDs. This report describes the mid‐term results of perventricular device closure of MVSDs at a single institution. Methods: The cardiology database of patients who underwent attempted perventricular MVSD closure from a single institution was reviewed. Results: Between January 2004 and December 2009, six patients underwent attempted perventricular MVSD closure in the operating room. Mean age was 9.8 ± 9.1 months; mean weight was 7.2 ± 3.7 kg. In five patients, closure was successful without use of bypass. In one patient, the device embolized to the left ventricle after release and patch closure of the MVSD was performed on cardiopulmonary bypass. The mean interval from the procedure to the most recent echocardiogram for the patients with successful perventricular closure was 39.8 ± 25.2 months. Three patients demonstrated no residual shunt at the last echocardiogram. Two patients had mild, hemodynamically insignificant shunting; one had a left ventricular pseudoaneurysm that was embolized during repeat catheterization. Conclusions: Perventricular closure of MVSDs is attractive because it overcomes the limitations of surgery and catheterization. Additionally, it spares the need for cardiopulmonary bypass and its comorbidities. In some instances, however, successful deployment of the device is not possible. Our mid‐term results demonstrate overall success but identify possible complications that are not immediately identified in the short term. © 2011 Wiley‐Liss, Inc.
Coarctate versus Pericyclic Reactivity in Naphthalene‐Fused Azo–Ene–Ynes: Synthesis of Benzocinnolines and Benzoisoindazoles
Authors: McClintock Sean P. , Zakharov Lev N. , Herges Rainer , Haley Michael M. 
Published: May 2011

AbstractThe cyclization reactions of naphthalene‐fused azo–ene–yne compounds are explored both computationally and experimentally. Calculations reveal that naphtho‐fusion to an azo–ene–yne scaffold does not significantly alter the transition state energies compared to the benzene‐based systems; however, fusing the naphthalene in an angular fashion leads to lower energy intermediates due to the creation of arenes possessing greater aromaticity. Experimentally, the cyclization of the angular systems yields not only the expected monomeric benzocinnolines and benzoisoindazoles, but also several dimeric structures, including one that readily isomerizes in the presence of light and/or trace acid.