bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myo‐InositolTrisPyroPhosphate Treatment Leads to HIF‐1α Suppression and Eradication of Early Hepatoma Tumors in Rats
Authors: Aprahamian Marc , Bour Gaétan , Akladios Chérif Y. , Fylaktakidou Konstantina , Greferath Ruth , Soler Luc , Marescaux Jacques , Egly Jean‐Marc , Lehn Jean‐Marie , Nicolau Claude 
Published: March 2011

AbstractMyo‐inositol trispyrophosphate (ITPP), a synthetic allosteric effector of hemoglobin, increases the regulated oxygen‐releasing capacity of red blood cells (RBCs), leading to suppression of hypoxia‐inducible factor 1α (HIF‐1α) and to down‐regulation of hypoxia‐inducible genes such as vascular endothelial growth factor (VEGF). As a consequence, tumor growth is markedly affected. The effect of weekly intravenous injection of ITPP on an orthotopic, syngenic rat hepatocellular carcinoma (HCC) model was compared to that for untreated animals and animals subjected to conventional Doxorubicin chemotherapy. The longitudinal examination of HCC was performed by microCT imaging, and the cellular and molecular changes were evaluated by histology and Western blotting analysis of HIF‐1α, VEGF, and caspase‐3 gene expression in the tumor and in the surrounding liver. Hematologic impact was evaluated by blood cell‐count measurement and determination of P50 (oxygen partial pressure for a 50 % oxygen saturation of hemoglobin). The HCC evaluation by microCT revealed a high potency of ITPP for tumor growth inhibition, thus allowing long‐term survival and even cure of almost all the treated animals. The P50 value of hemoglobin in RBCs underwent a shift of 30 % following ITPP injection. Under these conditions, HIF‐1α activity was strongly decreased, VEGF expression was down‐regulated, and apoptosis was induced in HCC and surrounding liver cells, as indicated by Caspase‐3 expression. ITPP did not affect hematologic parameters during treatment. The observations of in vivo tumor eradication suggest a significant clinical potential for ITPP in cancer therapy.
STEM HAADF Tomography of Molybdenum Disulfide with Mesoporous Structure
Authors: Nan Feihong , Song Chaojie , Zhang Jiujun , Hui Rob , Chen Jinwen , Fairbridge Craig , Botton Gianluigi A. 
Published: March 2011

AbstractA highly ordered mesoporous molybdenum disulfide has been developed for catalysis in heavy oil refining. The morphology, structure, and composition of the material have been systematically characterized with advanced electron microscopy techniques. Scanning transmission electron microscopy with high‐angle annular dark field tomography has been used to investigate the porous structure to give spatial information on the nanometre scale, and offer a direct view of individual porous particles in three‐dimensions. The pore‐size distribution, connectivity of the pores, and the mesoporous surface area have also been analyzed and offer useful information towards catalyst design.
The direct oxidation of hydrogen sulphide over activated carbons prepared from lignite coal and biochar
Authors: Azargohar R. , Dalai A. K. 
Published: March 2011

AbstractPhysically (steam) and chemically (KOH) activated carbons prepared from Luscar coal and biochar were used for removal of low concentrations of hydrogen sulphide (1 mol%) in methane. A modification method including acid treatment and thermal desorption in an inert atmosphere was used and the effects of this modification on the porous structure, surface chemistry, and ash content were studied. It increased total pore volume of activated carbons prepared from coal and biochar by 43% and 11%, respectively. Acid treatment changed the surface chemistry of activated carbons. Also, thermal desorption removed most of the acidic groups, especially carboxylic groups. The break‐through times corresponding to 80% removal of H2S using modified activated carbons prepared from coal and biochar were increased to 102 and 131 min, respectively. Also, the production of SO2 as an undesirable by‐product was less than 1.9% of H2S fed into the reactor.
Solids suspension with angle‐mounted agitators in unbaffled vessels
Authors: Myers Kevin J. , Herr Jonathan P. , Janz Eric E. 
Published: March 2011

AbstractSolids suspension using an angle‐mounted axial‐flow impeller in an unbaffled tank relies on proper placement of the impeller in the vessel such that swirling flow does not occur. Even with proper placement, the just‐suspended speed of an angle‐mounted agitator is often 75% higher than with vertical mounting on the centreline in a baffled tank, leading to torque and power requirements that average more than twice and five times higher, respectively. Angle‐mounted turbulent power numbers of axial‐flow impellers are generally similar to, but lower than the corresponding power numbers with vertical mounting on the centreline of a baffled tank.
Removal of strontium and barium from aqueous solutions by adsorption onto expanded perlite
Authors: Torab‐Mostaedi Meisam , Ghaemi Ahad , Ghassabzadeh Hamid , Ghannadi‐Maragheh Mohammad 
Published: March 2011

AbstractThe adsorption of strontium and barium from aqueous solution onto expanded perlite (EP) has been investigated as a function of pH, contact time, adsorbent dosage, and temperature. Sorption experiments indicated that the sorption capacity was dependent on operating variables and the process was strongly pH‐dependent. Equilibrium isotherm data were analysed using Langmuir, Freundlich, and Dubinin–Radushkevich isotherm models. The adsorption was well described by Langmuir isotherm model. The maximum adsorption capacity was found to be 1.14 and 2.486 mg/g for Sr (II) and Ba (II) from the Langmuir isotherm model at 20°C, respectively. Two simplified kinetic models viz. pseudo‐first‐order and pseudo‐second‐order models were tested to describe the adsorption process. The kinetic data indicated that adsorption fitted well with the pseudo‐second‐order kinetic model. Using the equilibrium constant value obtained at four (20, 30, 40, and 50°C) different temperatures, the thermodynamic parameters of the adsorption (ΔG°, ΔH°, and ΔS°) were also determined. The results showed that the adsorption of Sr (II) and Ba (II) ions on EP was exothermic and spontaneous.
Wettability of porous two‐dimensional ZnO nanocrystal films
Authors: Shi D. , Wang X. C. , Yao Z. W. , Liu F. , Zhang X. B. , Cheng J. P. 
Published: March 2011

AbstractLarge‐scale two‐dimensional ZnO nanocrystal films on aluminum substrate were fabricated by a one‐step hydrothermal method under mild conditions, where all the ZnO nanocrystals had a lamellar structure generally perpendicular to the substrates and formed network‐like porous configurations. The morphologies of the films were dependent on both the reaction temperature and concentration of zinc. The wettability of the ZnO films was assessed by measuring the water contact angle without any surface functionalisation. The porous structures of the as‐prepared films could effectively enhance its hydrophobicity and the water contact angle ranged from 40° to 135° depending on the surface morphology and the arrangement of ZnO planes, indicating a simple and promising route to make aluminum surface waterproof and even self‐cleaning. The hydrophobic ZnO surface could be switched to hydrophilic state by UV irradiation.
Ab initio Study of Electronic Structure and Properties of Crystalline of 1,5‐Diamino‐1,2,3,4‐tetrazole
Authors: Shang Jing , Zhang Jianguo , Zhang Tonglai , Shu Yuanjie , Zhang Shaowen , Huang Huisheng 
Published: March 2011

AbstractDensity functional method was applied to study 1,5‐diamino‐1,2,3,4‐tetrazole (DAT, CH4N6) in both gaseous and bulk states. The banding and electronic structures of crystalline have been investigated at DFT‐B3LYP/ 6‐311G** level of theory. Relaxed crystal structure compares well with experimental data. The light fluctuation of the frontier orbital, which is mainly formed by atomic orbital of N(4) (heterocycle), is the most reactive part of the molecule, which is in good agreement with the experimental results. The energy gap is 9.035 eV, which indicates that DAT is an insulator. The distribution of electrostatic potential is uniform, indicating DAT is insensitive. The charge density of the intermolecular regions in the plane is not overlaid, indicating that the intermolecular interaction between the neighboring molecules along this direction in the bulk is very weak. The overlap populations of N(1)N(2) bonds are much less than those of other bonds, therefore the N(1)N(2) bonds first rupture by external stimuli.
Crystal Structure and Theoretical Calculation of 1,4‐Bis‐(1‐ferrocenesulfonyl‐2‐benzimidazolyl) Butane
Authors: Yue Kefen , Zhuo Fei , Zhai Gaohong , Hou Lei , Hou Yibo , Yin Bing , Wang Yaoyu 
Published: March 2011

AbstractA N,N′‐bisferrocenesulfonyl bisbenzimidazole compound 1,4‐bis(1‐ferrocenesulfonyl‐2‐benzimidazolyl) butane was prepared. Its crystal structure was determined. The crystal belongs to triclinic with space group P‐1 and a=0.87241(13) nm, b=0.97553(15) nm, c=1.4120(2) nm, and α=83.041(2) °, β=72.454(2)°, γ=69.732(2)°, the unit cell volume V=1.0746(3) nm3, the molecule number in one unit cell Z=1, the absorption coefficient μ=1.191 mm−1, the calculated density Dc=1.584 g/cm3. The theoretical investigation of the compound as a structure unit was fully optimized by B3LYP/6‐31G method in Gaussian 03 package, and the most stable structure of the compound in theory was obtained. The two results were compared. The optimized structure was in accordance with the crystal structure in the main, suggesting that the molecular geometry optimization of the structures was reliable and the calculation method used was reliable. The distribution of atomic charges and the energy, and composition of frontier molecular orbits were analyzed. Thermal analysis indicated that it is stable before melting.
Highly Efficient Hydrogenation of Methyl Propionate to Propanol over Hydrous Zirconia Supported Ruthenium
Authors: Fan Guangyin , Zhou Yafen , Fu Haiyan , Ye Xiaoli , Li Ruixiang , Chen Hua , Li Xianjun 
Published: March 2011

AbstractHydrous zirconia supported ruthenium catalyst Ru/ZrO2·xH2O, prepared by co‐precipitating ruthenium trichloride and zirconium oxychloride with ammonia, was able to catalyze efficiently methyl propionate to propanol under the mild conditions. In aqueous system, the propanol yield of >99% was achieved under the conditions of reaction temperature of 150°C and hydrogen pressure of 5.0 MPa, while in non‐aqueous system the maximum propanol yield was only 47.0%. FTIR spectra and hydrogenation results indicated that the high catalytic performance of Ru/ZrO2·xH2O in aqueous phase results from the cooperation effect between water as a solvent and hydroxyl groups on the surface of carrier.
Synthesis, Crystal Structure and Optical Properties of Europium Trifluoroacetate Complexes with 1,10‐Phenanthroline and 2,2′‐Bipyridine
Authors: She Jiangbo , Cui Xiaoxia , Hou Chaoqi , Gao Chao , Wei Wei , Peng Bo 
Published: March 2011

AbstractTwo europium trifluoroacetate complexes, Eu(CF3COO)3·phen (1) and Eu(CF3COO)3·bpy (2) (where phen=1,10‐phenanthroline, bpy=2,2′‐bipyridine), were synthesized and characterized by elemental analysis, Fourier transform infrared spectroscopy (FT‐IR), photoluminescence (PL) spectroscopy and thermogravimetric analysis (TA). Single‐crystal X‐ray structure has been determined for the complex [Eu2(CF3COO)6·(phen)3·(H2O)2]·EtOH. The crystal structure of [Eu2(CF3COO)6·(phen)3·(H2O)2]·EtOH shows that two different coordination styles with europium ions coexist in the same crystal and have entirely different coordination geometries and numbers. This crystal can be considered as an 1:1 adduct of [Eu(CF3COO)3·(Phen)2·H2O]·EtOH (9‐coordination part) and Eu(CF3COO)3·phen·H2O (8‐coordination part). The excitation spectra of the two complexes demonstrate that the energy collected by "antenna ligands" is transferred to Eu3+ ions efficiently. The room‐temperature PL spectra of the complexes are composed of the typical Eu3+ ions red emission, due to transitions between 5D0→7FJ(J=0→4). The lifetimes of 5D0 of Eu3+ in the complexes were examined using time‐resolved spectroscopic analysis, and the lifetime values of Eu(CF3COO)3·phen and Eu(CF3COO)3·bpy were fitting with bi‐exponential (2987 and 353 µs) and monoexponential (3191 µs) curves, respectively. In order to elucidate the energy transfer process of the europium complexes, the energy levels of the relevant electronic states had been estimated. The thermal analyses indicate that they are all quite stable to heat.
Investigation of the Effect of Metallic Lewis Acid on the Nitrolysis of [3,7‐Diacetyl‐1,3,5,7‐tetraazabicyclo(3.3.1)‐nonane] and Hexamine
Authors: Shi Liangwei , Yu Menglong , Zhang Yazhu , Qin Guangming , Lü Jian , Zhao Gang 
Published: March 2011

AbstractThe effect of metallic ions on the nitrolysis of DAPT [3,7‐diacetyl‐1,3,5,7‐tetraazabicyclo(3.3.1)nonane] and HA (hexamine) was investigated by experimental and theoretical approaches. The combinatorial reagent, M(NO−3)n/Ac2/NH4NO3 (M=Mg2+, Cu2+, Pb2+, Bi3+, Fe3+ and Zr4+), was found to be efficient in the experiment of the nitrolysis of DAPT. A key intermediate during the nitrolysis of DAPT was detected by 1H NMR. The formation mechanism of the intermediate was proposed and analyzed. Some discrepant results for the nitrolysis of DAPT and HA catalyzed by different metallic nitrates were explained based on hard‐soft and acid‐base principle and stabilized energy of ion‐complex. From the latter point of view, some cations with high polarizable ligands, e.g., OSO2CF3−, (CF3SO2)2N−, and (C4F9SO2)2N−, can increase the yields. Two newly designed catalysts, Cu[(CF3SO2)2N]2 and Cu[(C4F9SO2)2N]2, were tested to be highly efficient.
An Efficient Synthesis of 3‐Alkyl‐2‐alkyliminooxazolidin‐4‐one via a Domino Reaction
Authors: Liu Yongwei , Li Zhengning , Jiang Lan , Zheng Aijun 
Published: March 2011

Abstract3‐Alkyl‐2‐alkyliminooxazolidin‐4‐ones were prepared from a copper‐catalyzed domino intermolecular nucleophilic addition of α‐hydroxy‐(or mecapto) carboxylic acid ester to carbodiimide and a followed nucleophilic substitution of the formed amino group to carboxylic acid ester. The reactions could be performed under convenient conditions and good yields were achieved in most cases.
Carbohydrate Coated Polymer Particles: Preparation and Protein‐binding Studies
Authors: Sun Zicai , Wei Zheng , Chen Jianjun , Wei Kemei 
Published: March 2011

AbstractA facile and effective organic synthesis route was provided for preparation of the carbohydrate coated polymer small particles. First, amino‐activated particles were prepared from PAN (polyacrylonitrile) by the heterogeneous cross‐linking method, then the amino groups on the particle were converted into hydrazide groups by N‐alkylation and hydrazine activation, meanwhile the length of linker was prolonged to the designed value. FTIR (Fourier Transform Infrared Spectroscopy) was used to study the reactions in the synthesis steps and to optimize part of the synthesis conditions. Two carbohydrates (maltose and heparin) were then directly coupled to the hydrazide‐activated particles in a relative high yield, the obtained particles were used to interact with BSA (bovine serum albumin) and typical heparin‐binding proteins. All of these particles had some nonspecific interactions with proteins and heparin coated particles showed additional strong binding ability with the heparin‐binding proteins. Data also showed that a longer linker length not only weakened nonspecific interaction but also increased the specific binding ability. As the carbohydrate coated particles are independent, flexible and easily detectable, they should be good acceptors for the diverse bioactive studies of carbohydrates.
Grafting of 4‐Vinyl Pyridine onto Nylon‐6 Initiated by Redox System
Authors: Zhou Jian , Bai Libin , Qin Hong , Liu Yinghai 
Published: March 2011

AbstractThe graft copolymerization of 4‐vinyl pyridine (4VP) onto nylon‐6 (PA6) was studied by using potassium diperiodatonickelate(IV) (DPN)‐PA6 redox system in alkaline medium. The structures of graft copolymers were confirmed by Fourier transfer infrared spectroscopy (FTIR) and X‐ray diffraction. The properties of graft copolymers were investigated by thermogravimetric analysis (TGA). A mechanism was proposed to explain the generation of radicals and the initiation. The effects of reaction variables, such as the initiator concentration, the ratio of 4VP to PA6, pH as well as reaction temperature and time were investigated. Graft copolymers with high grafting efficiency (>95%) were obtained, which indicated that DPN‐PA6 redox system is an efficient initiator for this graft copolymerization. The quaternized PA6‐g‐P4VP (QPAVP) was proved to be an excellent adsorbent to heavy metal ions.
Preparation of Novel Silica Nanoparticles with Controllable Fluorescence Intensity from Porphyrin‐Bridged Silsesquioxane
Authors: Guo Ximing , Guo Bin , Sun Xuemei , Zhang Qingyuan , Shi Tongshun 
Published: March 2011

AbstractA method for the fabrication of an improved class of controllable fluorescence intensity, highly sensitive and photostable porphyrin doped silica nanoparticles (PDSNPs) was demonstrated. The fluorescence intensity of PDSNPs could be controlled by finely tuning self‐dissociated time of the precursor of porphyrin‐bridged silsesquioxane. Porphyrin was well dispersed into the silica matrix due to the covalent attachment in the system, thus entirely avoiding the porphyrin leakage and fluorescence quenching effects. The resultant PDSNPs with a narrow size‐distributed region and a regular spherical structure can be attained.
Effect of Organic Additives on the Performance of Nano‐sized Ru‐Zn Catalyst
Authors: Sun Haijie , Chen Zhihao , Guo Wei , Zhou Xiaoli , Liu Zhongyi , Liu Shouchang 
Published: March 2011

AbstractA novel Ru‐Zn catalyst was prepared by coprecipitation. The catalyst was characterized by XRF, XRD and TEM. The effects of organic additives on the performance of the Ru‐Zn catalyst for benzene selective hydrogenation to cyclohexene were investigated. The results showed that the catalyst was composed of Ru and Zn in molar ratio of 33.8:1, and the most probable value of the Ru crystallite size in the catalyst was 5.1 nm. The modification of Ru with Zn and the small size effect were the main cause why the catalyst exhibited the high activity and the excellent cyclohexene selectivity. When PEG (polyethylene glycol) was used as an additive, the activity of the catalyst decreased, and the cyclohexene selectivity increased with the increase of the PEG molecular weight. With the addition of PEG‐20000, a cyclohexene selectivity of 78.9% at a benzene conversion of 68.7% and a maximum cyclohexene yield of 61.4% were obtained. With diethanolamine and triethanolamine as additives, cyclohexene yields were as high as 58.9% and 58.2%, respectively.
Target‐Selective Drug Delivery through Liposomes Labeled with Oligobranched Neurotensin Peptides
Authors: Falciani Chiara , Accardo Antonella , Brunetti Jlenia , Tesauro Diego , Lelli Barbara , Pini Alessandro , Bracci Luisa , Morelli Giancarlo 
Published: March 2011

AbstractThe structure and the in vitro behavior of liposomes filled with the cytotoxic drug doxorubicin (Doxo) and functionalized on the external surface with a branched moiety containing four copies of the 8–13 neurotensin (NT) peptide is reported. The new functionalized liposomes, DOPC‐NT4Lys(C18)2, are obtained by co‐aggregation of the DOPC phospholipid with a new synthetic amphiphilic molecule, NT4Lys(C18)2, which contains a lysine scaffold derivatized with a lipophilic moiety and a tetrabranched hydrophilic peptide, NT8–13, a neurotensin peptide fragment well known for its ability to mimic the neurotensin peptide in receptor binding ability. Dynamic light scattering measurements indicate a value for the hydrodynamic radius (RH) of 88.3±4.4 nm. The selective internalization and cytotoxicity of DOPC‐NT4Lys(C18)2 liposomes containing Doxo, as compared to pure DOPC liposomes, were tested in HT29 human colon adenocarcinoma and TE671 human rhabdomyosarcoma cells, both of which express neurotensin receptors. Peptide‐functionalized liposomes show a clear advantage in comparison to pure DOPC liposomes with regard to drug internalization in both HT29 and TE671 tumor cells: FACS analysis indicates an increase in fluorescence signal of the NT4‐liposomes, compared to the DOPC pure analogues, in both cell lines; cytotoxicity of DOPC‐NT4Lys(C18)2‐Doxo liposomes is increased four‐fold with respect to DOPC‐Doxo liposomes in both HT29 and TE671 cell lines. These effects could to be ascribed to the higher rate of internalization for DOPC‐NT4Lys(C18)2‐Doxo liposomes, due to stronger binding driven by a lower dissociation constant of the NT4‐liposomes that bind the membrane onto a specific protein, in contrast to DOPC liposomes, which approach the plasma membrane unselectively.
From β‐Amino‐γ‐sultone to Unusual Bicyclic Pyridine and Pyrazine Heterocyclic Systems: Synthesis and Cytostatic and Antiviral Activities
Authors: de Castro Sonia , Familiar Olga , Andrei Graciela , Snoeck Robert , Balzarini Jan , Camarasa María‐José , Velázquez Sonsoles 
Published: March 2011

AbstractHerein we describe the first successful application of the β‐amino‐γ‐sultone system as an intermediate for the synthesis of hitherto virtually unknown 3H‐[1,2]‐oxathiole [4,3‐b]pyridine and pyrazine 1,1‐dioxide bicyclic heterocyclic systems. All novel compounds were evaluated for their antiviral and cytostatic activities. Compounds 3 a, 15 a, and 21 a inhibited HIV‐1‐induced cytopathicity. Compound 7 showed remarkable cytostatic activity, and can be regarded as a potential antitumor candidate for further exploration.
Retracted: Up‐regulation of microRNA‐145 promotes differentiation by repressing OCT4 in human endometrial adenocarcinoma cells
Authors: Wu Yanjing , Liu Shupeng , Xin Hong , Jiang Jing , Younglai Edward , Sun Shuhan , Wang Huilan 
Published: March 2011

AbstractRetraction: Yanjing Wu, Shupeng Liu, Hong Xin, Jing Jiang, Edward Younglai, Shuhan Sun, and Huilan Wang. Up‐Regulation of MicroRNA‐145 Promotes Differentiation by Repressing OCT4 in Human Endometrial Adenocarcinoma Cells. Cancer 2011;117:3989‐3998.The above article, published online on March 1, 2011 in Wiley Online Library ( https://doi.org/10.1002/cncr.25944) has been retracted by agreement between the journal’s Editor‐in‐Chief, Dr. Suresh S. Ramalingam, and Wiley Periodicals LLC. The retraction has been agreed upon following concerns raised by a third party (1) regarding flaws and inconsistencies between the results presented and the experimental methods described. In addition, evidence of image manipulation was also detected. As a result, the Editor‐in‐Chief considers the conclusions of this article to be invalid.Park Y, West RA, Pathmendra P, Favier B, Stoeger T, Capes‐Davis A, Cabanac G, Labbé C, Byrne JA. “Identification of human gene research articles with wrongly identified nucleotide sequences.” Life Sci Alliance. 2022 Jan 12;5(4):e202101203. doi: 10.26508/lsa.202101203. Print 2022 Apr.