bluuebunny/crossref_metadata_2025_split huggingface dataset:
Noonan‐like syndrome with loose anagen hair associated with growth hormone insensitivity and atypical neurological manifestations
Authors: Capalbo D. , Melis D. , De Martino L. , Palamaro L. , Riccomagno S. , Bona G. , Cordeddu V. , Pignata C. , Salerno M. 
Published: March 2012

AbstractNoonan‐like syndrome with loose anagen hair (NS/LAH; OMIM 607721), recently related to the invariant c.4A>G missense change in SHOC2, is characterized by features reminiscent of Noonan syndrome. Ectodermal involvement, short stature associated with growth hormone (GH) deficiency (GHD), and cognitive deficits are common features. We report on a patient with molecularly confirmed NS/LAH exhibiting severe short stature associated with GH insensitivity (GHI), and chronic complex tics, a neurological feature never described before in this syndrome. IGF1 generation test revealed only a blunted increase in IGF1 after exogenous GH treatment, revealing mild GH insensitivity associated with proper STAT5 activation. Most common causes of secondary tics in childhood were excluded. © 2012 Wiley Periodicals, Inc.
Genome wide study of maternal and parent‐of‐origin effects on the etiology of orofacial clefts
Authors: Shi Min , Murray Jeffrey C. , Marazita Mary L. , Munger Ronald G. , Ruczinski Ingo , Hetmanski Jacqueline B. , Wu Tao , Murray Tanda , Redett Richard J. , Wilcox Allen J. , Lie Rolv T. , Jabs Ethylin Wang , Wu‐Chou Yah Huei , Chen Philip K. , Wang Hong , Ye Xiaoqian , Yeow Vincent , Chong Samuel S. , Shi Bing , Christensen Kaare , Scott Alan F. , Patel Poorav , Cheah Felicia , Beaty Terri H. 
Published: March 2012

AbstractWe performed a genome wide association analysis of maternally‐mediated genetic effects and parent‐of‐origin (POO) effects on risk of orofacial clefting (OC) using over 2,000 case‐parent triads collected through an international cleft consortium. We used log‐linear regression models to test individual SNPs. For SNPs with a P‐value <10−5 for maternal genotypic effects, we also applied a haplotype‐based method, TRIMM, to extract potential information from clusters of correlated SNPs. None of the SNPs were significant at the genome wide level. Our results suggest neither maternal genome nor POO effects play major roles in the etiology of OC in our sample. This finding is consistent with previous genetic studies and recent population‐based cohort studies in Norway and Denmark, which showed no apparent difference between mother‐to‐offspring and father‐to‐offspring recurrence of clefting. We, however, cannot completely rule out maternal genome or POO effects as risk factors because very small effects might not be detectable with our sample size, they may influence risk through interactions with environmental exposures or may act through a more complex network of interacting genes. Thus, the most promising SNPs identified by this study may still be worth further investigation. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Long‐term survival in infantile malignant autosomal recessive osteopetrosis secondary to homozygous p.Arg526Gln mutation in CLCN7
Authors: Kantaputra Piranit Nik , Thawanaphong Saranya , Issarangporn Witchapong , Klangsinsirikul Phennapha , Ohazama Atsushi , Sharpe Paul , Supanchart Chayarop 
Published: March 2012

AbstractInfantile malignant autosomal recessive osteopetrosis (ARO; OMIM 259700) has been reported to be associated with mutations in TCIRG1, CLCN7, or OSTM1. ARO caused by homozygous (or compound heterozygous) mutations in CLCN7, as described here, is usually diagnosed at birth or early in infancy due to generalized osteosclerosis and severe hematologic deficits. The maximal life expectancy of patients with ARO in the absence of bone marrow transplantation is thought to be 10 years. We report on a 25‐year‐old Thai man who is affected with ARO. Clinical features include proportionate short stature, vision impairment, esotropia, exophthalmos, mild hearing loss, and hepatosplenomegaly. Pancytopenia was present and the patient had frequent illnesses. Radiographs showed generalized osteosclerosis with almost no visible of bone marrow spaces. Dense maxilla and mandible with impacted and malformed teeth were observed. Multiple fractures were reported. He developed osteomyelitis of the mandible on four separate occasions, and partial mandibulectomy was performed. Molecular studies showed that there were no pathogenic mutations in TCIRG1. However, mutation analysis of CLCN7 revealed a homozygous missense mutation (p.Arg526Gln). This patient is, it appears, the longest lived individual with ARO ever reported. Evaluation of osteoclastogenesis in our patient demonstrated very large immature osteoclasts with a high number of nuclei. © 2012 Wiley Periodicals, Inc.
On the Use of Feedback Control in the Design of Computing System Components
Authors: Maggio Martina , Papadopoulos Alessandro Vittorio , Leva Alberto 
Published: March 2012

AbstractFeedback controllers are typically applied to computing systems by acting on some quantities (“tunable parameters” in the computer science lexicon, e.g., a packet drop rate) to attain some goal (e.g., a required bandwidth allocation). In other words, control loops are closed around the computing system. In the authors' opinion, this is definitely a partial use of control. Many critical parts of computing systems should not be controlled, but rather redesigned in the form of controllers. This paper formalises the statement above and illustrates some results, including application examples, to demonstrate the advantages of such a novel approach, and to stimulate research on the matter.
Smooth Switching Output Tracking Control for LPV Systems
Authors: Song Lei , Yang Jianying 
Published: March 2012

AbstractThis paper is concerned with the problem of smooth switching state feedback controller design for aircraft dynamic systems with multiple operating points. Based on the theory of robust control, a single state feedback controller which considers smooth switching is constructed. With the constant controller, the output response can be considerably improved in the switching process when the flight condition changes. An example for autopilot design of an F‐18 aircraft is given to illustrate the effectiveness of the proposed approach.
Hermite Polynomials for Iterative Output Replanning for Flat Systems Affected by Additive Noise
Authors: Consolini Luca , Lini Gabriele , Piazzi Aurelio 
Published: March 2012

AbstractThe paper considers the output tracking problem for nonlinear systems whose performance output is also a flat output of the system itself. A desired output signal is sought on the actual performance output by using a feedforward inverse input that is periodically updated with discrete‐time feedback of the sampled state of the system. The proposed method is based on an iterative output replanning that uses the desired output trajectory and the sampled state to replan an output trajectory whose inverse input helps in reducing the tracking error. This iterative replanning exploits the Hermite interpolating polynomials to achieve an overall arbitrarily smooth input and a tracking error that can be made arbitrarily small if the state sampling period is sufficiently small and mild assumptions are considered. Some simulation results are presented for the cases of a unicycle and a one‐trailer system affected by additive noise.
High‐field magneto‐photoluminescence of semiconductor nanostructures
Authors: Hayne Manus , Bansal Bhavtosh 
Published: March 2012

ABSTRACTWe review the photoluminescence of semiconductor nanostructures in high magnetic fields, concentrating on the effects of the applied magnetic field on orbital motion (wave function extent), which is probed in experiments on large ensembles. We present an overview of the physics of excitons in high magnetic fields in 3‐ and 2‐D before introducing the zero‐dimensional case. We then discuss the physics of quantum‐dot excitons in high magnetic fields with particular attention to the approximate analytical models used to interpret experimental results. This is followed by a brief description of a typical high‐field magneto‐photoluminescence setup. We then present four examples of magneto‐photoluminescence experiments on different materials systems chosen from our own research to illustrate how high magnetic fields can be used to reveal new insights into the physics of semiconductor nanostructures. Copyright © 2012 John Wiley & Sons, Ltd.
Impact of anastomotic complications on outcome after laparoscopic gastrectomy for early gastric cancer
Authors: Nagasako Y , Satoh S , Isogaki J , Inaba K , Taniguchi K , Uyama I 
Published: March 2012

Abstract

Background
The effects of anastomotic complications after laparoscopically assisted gastrectomy (LAG) have not been studied widely. The aims of this observational study were to identify potential factors that predict anastomotic complications and investigate the impact of anastomotic complications in patients undergoing gastrectomy for early gastric cancer.

Methods
The study included consecutive patients with histologically proven T1 gastric adenocarcinoma treated by LAG with regional lymphadenectomy between August 1997 and March 2008, who had not received neoadjuvant chemotherapy. Anastomotic complications included anastomotic leakage, stricture and remnant gastric stasis of grade II or higher (modified Clavien classification) and were identified by clinical assessment and confirmatory investigation. Predictive factors for the development of anastomotic complications were identified by univariable and multivariable analyses. Long-term survival with or without anastomotic complications was examined.

Results
Anastomotic complications occurred in 37 (9·3 per cent) of 400 patients. Multivariable analysis indicated surgeon experience as the only independent predictor of anastomotic complications (hazard ratio 4·40, 95 per cent confidence interval 2·04 to 9·53; P &lt; 0·001). Patients with anastomotic complications had a significantly worse overall 5-year survival rate than those without (81 versus 94·2 per cent; P = 0·009).

Conclusion
Anastomotic complications after LAG lead to worse long-term survival.
Early statin treatment prior to primary PCI for acute myocardial infarction: REPERATOR, a randomized placebo‐controlled pilot trial
Authors: Post Simone , Post Martijn C. , van den Branden Ben J. , Eefting Frank D. , Goumans Marie‐José , Stella Pieter R. , van Es Hendrik W. , Wildbergh Thierry X. , Rensing Benno J. , Doevendans Pieter A. 
Published: March 2012

AbstractObjective: The aim of this pilot study was to determine whether early atorvastatin treatment will reduce left ventricle (LV) remodeling, infarct size, and improve microvascular perfusion. Background: In animal studies, early statin therapy reduces reperfusion injury after a percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Methods: Forty‐two consecutive patients (82% male, mean age 61.2 ± 9.8) who underwent a primary PCI for a first ST‐elevated AMI were randomized for pretreatment with atorvastatin 80 mg (n = 20) or placebo (n = 22) and continued with the same dosage daily for 1 week. All patients received atorvastatin 80 mg once daily 7 days after primary PCI. The LV function and infarct size were measured by magnetic resonance imaging within 1 day, at 1 week, and 3 months follow up. The primary endpoint was the end‐systolic volume index (ESVI) at 3 months. Secondary endpoints were global LV function measurements, myocardial infarct size, biochemical cardiac markers, TIMI flow, and ST‐T elevation resolution. Results: ESVI 3 months after AMI was 25.1 mL/m2 in the atorvastatin arm and 25.0 mL/m2 in the placebo arm (P = 0.74). The differences in change from baseline to 3 months follow up in global LV function and myocardial infarct size did not differ between both treatment arms. Furthermore, biochemical markers, TIMI flow, and ST‐T elevation resolution did not differ between atorvastatin and placebo arm. Conclusions: In this pilot study, pretreatment with atorvastatin in an acute myocardial infarction does not result in an improved cardiac function, microvascular perfusion, or decreased myocardial infarct size. © 2012 Wiley Periodicals Inc.
Aneurysm formation after drug‐eluting balloon treatment of drug‐eluting in‐stent restenosis: First case report
Authors: Vassilev Dobrin , Hazan Maxim , Dean Larry 
Published: March 2012

AbstractA 55‐year‐old male underwent paclitaxel‐eluting stent implantation in a bifurcation lesion of his left anterior descending artery (LAD) during an episode of unstable angina in 2008. A late in‐stent restenosis developed 15 months after implantation of the drug‐eluting stent (DES) and was treated with paclitaxel eluting balloon. Two months later, during angiography for functional assessment of the significance of lesions in the circumflex artery, an aneurysm at the place of drug‐eluting balloon (DEB) inflation was observed. The patient was left on double antiplatelet therapy and scheduled for clinical observation after 3 months and control coronary angiography after 6 months for aneurysm progression follow‐up. © 2012 Wiley Periodicals, Inc.
Percutaneous interventions in high‐risk patients following mustard repair of transposition of the great arteries
Authors: Hill Kevin D. , Fleming Gregory , Curt Fudge J. , Albers Erin L. , Doyle Thomas P. , Rhodes John F. 
Published: March 2012

AbstractObjectivesTo assess safety, efficacy, and intermediate term outcomes of percutaneous interventions in Mustard patients.BackgroundBaffle leaks and obstruction are present in 20% of Mustard survivors. Surgical reintervention is associated with high mortality.MethodsRetrospective review of percutaneous interventions performed at three adult congenital catheterization programs.ResultsOverall, 26 catheterizations and 29 interventions were performed in 22 patients (mean age 32.4 ± 8.3 years). Previous laser pacemaker lead extraction was successful in seven of seven procedures where the lead was at risk. Stent placement was successful in all 18 patients with systemic venous baffle (SVB) obstruction (mean gradient: 6.2 ± 3.4–0.6 ± 1.0 mm Hg; P < 0.01, narrowest diameter 4.5 ± 4.5–17.1 ± 3.9 mm; P < 0.01). Balloon angioplasty was performed in two patients for pulmonary venous baffle (PVB) obstruction with mixed results. Baffle leak interventions included device occlusion (n = 6), coil occlusion (n = 1), and covered stent occlusion (n = 3). Postprocedural residual leaks were demonstrated in three of eight. In two of the three the residual leak was not appreciable at 1‐year follow‐up. No patient experienced leak or obstruction related symptom recurrence (mean follow‐up: 33.4 ± 29.5 months). Complications included one death secondary to ventricular arrhythmia 2 days after PVB angioplasty and device related inferior SVB obstruction with resolution following stent placement.ConclusionsStent placement for SVB obstruction following Mustard repair is effective and likely safer than surgical intervention. Baffle leak occlusion can be safely accomplished but residual leaks are common in the short term. © 2012 Wiley Periodicals Inc.
Fast Prediction Method for Steady‐State Heat Convection
Authors: Wang Y. , Yu B. , Sun S. 
Published: March 2012

AbstractA reduced model by proper orthogonal decomposition (POD) and Galerkin projection methods for steady‐state heat convection is established on a nonuniform grid. It was verified by thousands of examples that the results are in good agreement with the results obtained from the finite volume method. This model can also predict the cases where model parameters far exceed the sample scope. Moreover, the calculation time needed by the model is much shorter than that needed for the finite volume method. Thus, the nonuniform POD‐Galerkin projection method exhibits high accuracy, good suitability, and fast computation. It has universal significance for accurate and fast prediction. Also, the methodology can be applied to more complex modeling in chemical engineering and technology, such as reaction and turbulence.
ChemInform Abstract: The Structure of (H3O) 2B12F12·6H2O — A CCP Lattice of B12F122‐ Anions Intercalated with a Nonplanar Network of O—H···O Connected O6 Rings.
Authors: Bukovsky Eric V. , Fiedler Stephanie R. , Peryshkov Dmitry V. , Popov Alexey A. , Strauss Steven H. 
Published: March 2012

AbstractThe title compound crystallizes in the monoclinic space group C2/m with Z = 2 (single crystal XRD).
ChemInform Abstract: F‐Doped Co3O4 Photocatalysts for Sustainable H2 Generation from Water/Ethanol.
Authors: Gasparotto Alberto , et al. et al. 
Published: March 2012

AbstractUndoped and F‐doped Co3O4 nanostructured films are prepared by plasma‐enhanced chemical vapor deposition from both fluorine‐free and fluorinated β‐diketonate cobalt derivatives [Co(dpm)2] (dpm: 2,2,6,6‐tetramethyl‐3,5‐heptanedionate) and [Co(hfa)2TMEDA] (hfa: 1,1,1,5,5,5‐hexafluoro‐2,4‐pentanedionate), respectively.
ChemInform Abstract: Palladium‐Catalyzed Oxidation of Vinyl Ether to Acetate with Hydrogen Peroxide.
Authors: Kon Yoshihiro , Chishiro Takefumi , Imao Daisuke , Nakashima Takuya , Nagamine Takashi , Hachiya Houjin , Sato Kazuhiko 
Published: March 2012

AbstractIn some cases it is necessary to add an organic solvent to form the desired product or to increase the yield.
ChemInform Abstract: Introduction of a Clean and Promising Protocol for the Synthesis of β‐Amino‐Acrylates and 1,4‐Benzoheterocycles: An Emerging Innovation.
Authors: Choudhary Garima , Peddinti Rama Krishna 
Published: March 2012

AbstractA simple protocol for the synthesis of title compounds (III), (V), (VII) and (IX) is established, by carrying out the transformations at exceptionally mild conditions, such as, ambient temperature, open to air, catalyst‐ and solvent‐free.
ChemInform Abstract: Facile Knoevenagel and Domino Knoevenagel/Michael Reactions Using Gel‐Entrapped Base Catalysts.
Authors: Shinde Shital , Rashinkar Gajanan , Kumbhar Arjun , Kamble Santosh , Salunkhe Rajashri 
Published: March 2012

AbstractThe gel‐entrapped KOH can be recycled and used in at least five cycles with only a slight loss of activity.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Oxidative Esterification Reaction of Aldehydes with Alkyl Halides under Aerobic Conditions.
Authors: Xin Yang‐Chun , Shi Shi‐Hui , Xie Dong‐Dong , Hui Xin‐Ping , Xu Peng‐Fei 
Published: March 2012

AbstractAn efficient IMesCl‐catalyzed oxidative esterification of various aromatic and aliphatic aldehydes with alkyl halides and alkyl tosylates is presented.
ChemInform Abstract: Synthesis of a New Class of Ligands Derived from Isosorbide and Their Application to Asymmetric Reduction of Aromatic Ketones by Transfer Hydrogenation.
Authors: Huynh Khanh‐Duy , Ibrahim Houssein , Kolodziej Emile , Toffano Martial , Vo‐Thanh Giang 
Published: March 2012

AbstractA variety of isosorbide‐derived amino alcohols as well as diamines such as (I) is prepared and tested as ligands in the Ru‐catalyzed asymmetric transfer hydrogenation of aromatic ketones.
ChemInform Abstract: Diphenyl Diselenide‐Assisted α‐Phenylthiolation of Carbonyl Compounds with Diphenyl Disulfide.
Authors: Anbou Hiroaki , Umeda Rui , Nishiyama Yutaka 
Published: March 2012

AbstractA catalytic system of cesium carbonate and diphenyl diselenide is successfully applied for the α‐phenylthiolation of carbonyl compounds (I).
ChemInform Abstract: Catalytic, Asymmetric, Interrupted Feist—Benary Reactions of α‐Tosyloxyacetophenones.
Authors: Calter Michael A. , Korotkov Alexander 
Published: March 2012

AbstractA new variant of the interrupted Feist—Benary reaction ‐ the condensation of α‐haloketones and 1,3‐dicarbonyl compounds ‐ uses α‐tosyloxyacetophenones (I) as electrophiles.
ChemInform Abstract: Synthesis of Some New 1H‐Benzimidazole‐2‐carboxamido Derivatives and Their Antimicrobial Activity.
Authors: Oezden Seckin , Usta Figen , Altanlar Nurten , Goeker Hakan 
Published: March 2012

AbstractCompound (IIIa) exhibits the best inhibitory activity against S.
ChemInform Abstract: A Powerful Palladium‐Catalyzed Multicomponent Process for the Preparation of Oxazolines and Benzoxazoles.
Authors: Boissarie Patrick J. , Hamilton Zoe E. , Lang Stuart , Murphy John A. , Suckling Colin J. 
Published: March 2012

AbstractThe three‐component coupling of an aryl halide (I), isocyanide (II), and an amino alcohol (III) and (VI) under Pd catalysis gives rise to the formation of oxazolines (IV) and benzoxazoles (VII), respectively, in high yields.
ChemInform Abstract: A New Synthetic Protocol for One‐Pot Preparations of 5‐Halo‐1,4‐disubstituted‐1,2,3‐triazoles.
Authors: Li Lingjun , Li Yanyan , Li Ran , Zhu Anlian , Zhang Guisheng 
Published: March 2012

AbstractThe CuI‐NCS and CuBr‐NCS reaction system is developed for the one‐pot preparation of 5‐halo‐triazoles using mild reaction conditions with a high tolerance of various sensitive groups.
ChemInform Abstract: Diastereoselective Access to Nonracemic 2‐cis‐Substituted and 2,6‐cis‐Disubstituted Piperidines.
Authors: Coia Nicolas , Mokhtari Naima , Vasse Jean‐Luc , Szymoniak Jan 
Published: March 2012

AbstractAccess to enantiopure amino ketones (III) and (X) via a hydrozirconation/transmetalation/ acylation sequence of protected 1‐aminobut‐3‐enes (I) and (X) is reported.
ChemInform Abstract: Synthesis of Thioglycosides in Room Temperature Ionic Liquid.
Authors: Santra Abhishek , Sau Abhijit , Misra Anup Kumar 
Published: March 2012

AbstractTreatment of per‐O‐acetylated sugar derivatives with thiols in the presence of boron trifluoride diethyl etherate in an ionic liquid affords the corresponding thioglycosides in good to very good yields.
ChemInform Abstract: Designing 2‐Aminoimidazole Alkaloids Analogues with anti‐Biofilm Activities: Structure—Activities Relationships of Polysubstituted Triazoles.
Authors: Linares D. , Bottzeck O. , Pereira O. , Praud‐Tabaries A. , Blache Y. 
Published: March 2012

AbstractA library of triazole‐based analogues of 2‐aminoimidazole marine alkaloids naamine A and isonaamine A (22 examples in all) are designed, synthesized using click chemistry and evaluated for their biofilm inhibitory activities.
ChemInform Abstract: Synthesis and anti‐HIV‐1 Activity of 4‐Substituted‐7‐ (2′‐deoxy‐2′‐fluoro‐4′‐azido‐β‐D‐ribofuranosyl)pyrrolo [2,3‐d]pyrimidine Analogues.
Authors: Chang Junbiao , et al. et al. 
Published: March 2012

AbstractTitle nucleoside (Va) shows promising activity against HIV‐1 replication.
ChemInform Abstract: New Diarylureas and Diarylamides Containing 1,3,4‐Triarylpyrazole Scaffold: Synthesis, Antiproliferative Evaluation Against Melanoma Cell Lines, ERK Kinase Inhibition, and Molecular Docking Studies.
Authors: Choi Won‐Kyoung , El‐Gamal Mohammed I. , Choi Hong Seok , Baek Daejin , Oh Chang‐Hyun 
Published: March 2012

AbstractDerivatives (Ib)—(Id), and (IIIa)—(IIIc) show the highest potency against A375P human melanoma cell line.