bluuebunny/crossref_metadata_2025_split huggingface dataset:
The communication model for real‐time web service in telecom domain
Authors: Bo Cheng , Jie Guo , Junliang Chen , Xiangwu Meng 
Published: May 2009

AbstractDevelopment of services that span over the Internet and Telecom networks is driving significant efforts towards the integration of services offered by Telecom operators. The telecommunications R&D community also starts adapting and developing similar service delivery platforms to offer a wide range of new value‐added services faster and more cost efficiently inspired by the success of Web service technologies for the development and deployment of IT services. In this paper, we have an analysis for Telecom Web services communication requirements and also propose Telecom Web services communication model considering the specific characteristics as state, asynchronous, event‐driven communications in Telecom domain. We focus on the design and implementation details for real‐time Web service communication model in Telecom domain, and as the framework of communication model for Telecom Web services, the enhanced state machine design and implementation, and the messages dispatching design and implementation for Telecom Web services communication model, and also illustrate the third party end call control scenarios. Finally, we give the conclusion and future essential work. Copyright © 2009 John Wiley & Sons, Ltd.
Characterisation of BaZr0.9Y0.1O3‐δ Prepared by Three Different Synthesis Methods: Study of the Sinterability and the Conductivity
Authors: Duval S. B. C. , Holtappels P. , Vogt U. F. , Stimming U. , Graule T. 
Published: May 2009

AbstractBaZr0.9Y0.1O3‐δ has been synthesised by three different methods: the solid‐state reaction, the spray pyrolysis and the spray drying. Significantly different apparent lattice parameters (between 0.4192 nm for the sample prepared by the solid‐state reaction method and sintered at 1,500 °C and 0.4206 nm for the sample prepared by the solid‐state reaction method and sintered at 1,720 °C) are observed after calcination and sintering, depending on the synthesis method and the sintering temperature. The bulk conductivity values also vary over several orders of magnitude (–7.2< log σb <–3.6 at 300 °C) depending on the synthesis method and the sintering temperature. These variations of the bulk conductivity and also the activation energy are correlated with variations of the apparent lattice parameter. The influence of the preparation method on the electrical properties is discussed. The grain boundaries are more resistive than the bulk. The variation of the grain boundary conductivity could be correlated to the microstructure in terms of the grain size.
On the Approximation of Transport Phenomena – a Dynamical Systems Approach
Authors: Dellnitz Michael , Froyland Gary , Horenkamp Christian , Padberg Kathrin 
Published: May 2009

AbstractTransport phenomena are studied in a large variety of dynamical systems with applications ranging from the analysis of fluid flow in the ocean and the predator‐prey interaction in jelly‐fish to the investigation of blood flow in the cardiovascular system. Our approach to analyze transport is based on the methodology of so‐called transfer operators associated with a dynamical system since this is particularly suitable. We describe the approach and illustrate it by two real world applications: the computation of transport for asteroids in the solar system and the approximation of macroscopic structures in the Southern Ocean (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
On the generation of conjugate flanks for arbitrary gear geometries
Authors: Johann A. , Scheurle J. 
Published: May 2009

AbstractIn this paper, we present a novel approach to three‐dimensional mathematical gearing theory. We start from a general formulation of the so called basic law of gear kinematics. Based on that we derive an analytic closed form solution for the generation of conjugate tooth flanks, given a (local) parametric representation for any prescribed flank profile. Also, we study the problem of constructing pairs of tooth flanks that give rise to a prescribed surface of action. Surfaces of action will be represented in an implicit global rather than in a parametric way. To illustrate the general theory, we consider a number of specific examples including the standard involute profile for spur gears as well as a more sophisticated three‐dimensional generalization of that (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Modelling disturbances in early sensory processing in schizophrenia
Authors: Popovych S. , Küpper T. , Müller R. , Brockhaus‐Dumke A. 
Published: May 2009

AbstractRecent results suggest that disturbances of information processing within the thalamo‐cortical circuit are central in the pathophysiology of schizophrenia. We derive a mathematical model based on phase oscillators to describe the neural activity within the thalamo‐cortical loop and show that the results derived from the corresponding equations coincide with experimental data obtained by EEG measurements. It is an important advantage of the mathematically based approach that information concerning activities in deeply localized brain areas which are not directly accessible to measurements becomes available. The mathematical model describes differences between healthy subjects and patients with schizophrenia by various states of phase locking between different brain areas involved (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Breaks invisible to the DNA damage response machinery accumulate in ATM‐deficient cells
Authors: Martín Marta , Terradas Mariona , Iliakis George , Tusell Laura , Genescà Anna 
Published: May 2009

AbstractAfter irradiation, ATM defective cells accumulate unrepaired double strand breaks (DSBs) for several cell divisions. At the chromosome level, unresolved DSBs appear as chromosome breaks that can be efficiently scored by using telomeric and mFISH probes. H2AX is immediately activated by ATM in response to DNA damage and its phosphorylated form, γH2AX, flanks the DSB through several megabases. The γH2AX‐labeling status of broken chromosome ends was analyzed in AT cells to check whether the DNA damage response was accurately taking place in these persistent DSBs. The results show that one quarter of the scored breaks are devoid of γH2AX foci in metaphase spreads from ATM‐deficient cells, and this fraction is significantly higher than in normal cells (χ2 < 0.05). Accumulation of sensor and repair proteins at damaged sites is a key event in the cellular response to DSBs, so MRE11 labeling at broken ends was also analyzed. While all γH2AX foci scored at visible broken ends colocalize with MRE11 foci, all γH2AX‐unlabeled breaks are also devoid of MRE11‐labeling. The present results suggest that a significant subset of the AT long‐lived DSBs may persist as “invisible” DSBs due to deficient detection by the DNA damage repair machinery. Eventually the properly signaled DSBs will be repaired while invisible breaks may indefinitely accumulate; most probably contributing to the AT cells' well known genomic instability. © 2009 Wiley‐Liss, Inc.
Parametric model‐based statistics for possible genotyping errors and sample stratification in sibling‐pair SNP data
Authors: Korostishevsky Michael , Malkin Ida , Spector Tim , Livshits Gregory 
Published: May 2009

AbstractThe detection of genotyping errors, based on apparent Mendelian incompatibilities in a sample of sib‐pairs, is a complicated problem. In the case of a single marker and unknown parental genotypes, all combinations of sib‐pair genotypes are self‐consistent. Moreover, the observed deviation from equilibrium genotype frequencies may result from genotyping errors as well as from the sample's stratification. This in turn, may profoundly affect the results of association and linkage analyses, and therefore an estimation of these factors should be done beforehand. Here we present several parametric models, and using likelihood ratio statistics, we suggest a method of combined analysis of genotyping errors and a sample stratification for randomly ascertained sib‐pair single nucleotide polymorphism (SNP) data. Specifically, we implemented two models of genotyping errors in either heterozygotes or homozygotes, and two models of sample stratification resulting from either the presence of families of different ethnic origin (e.g., a population admixture) or from a different ethnic origin of the parents in the family (e.g., intermarriage). The power of this method was established by Monte Carlo data simulation. The results clearly suggest that the proposed method is most efficient for detecting genotyping errors in heterozygotes, a common error caused by incorrect SNP data interpretation. We also provide an example of its application to real data. Genet. Epidemiol. 34:26–33, 2010. © 2009 Wiley‐Liss, Inc.
Discovering genetic ancestry using spectral graph theory
Authors: Lee Ann B. , Luca Diana , Klei Lambertus , Devlin Bernie , Roeder Kathryn 
Published: May 2009

AbstractAs one approach to uncovering the genetic underpinnings of complex disease, individuals are measured at a large number of genetic variants (usually SNPs) across the genome and these SNP genotypes are assessed for association with disease status. We propose a new statistical method called Spectral‐GEM for the analysis of genome‐wide association studies; the goal of Spectral‐GEM is to quantify the ancestry of the sample from such genotypic data. Ignoring structure due to differential ancestry can lead to an excess of spurious findings and reduce power. Ancestry is commonly estimated using the eigenvectors derived from principal component analysis (PCA). To develop an alternative to PCA we draw on connections between multidimensional scaling and spectral graph theory. Our approach, based on a spectral embedding derived from the normalized Laplacian of a graph, can produce more meaningful delineation of ancestry than by using PCA. Often the results from Spectral‐GEM are straightforward to interpret and therefore useful in association analysis. We illustrate the new algorithm with an analysis of the POPRES data [Nelson et al., 2008]. Genet. Epidemiol. 34:51–59, 2010. © 2009 Wiley‐Liss, Inc.
Role of the oligodendroglial cytoskeleton in differentiation and myelination
Authors: Bauer Nina G. , Richter‐Landsberg Christiane , Ffrench‐Constant Charles 
Published: May 2009

AbstractOligodendrocytes, the myelin‐forming cells of the central nervous system, are in culture characterized by an elaborate process network, terminating in flat membranous sheets that are rich in myelin‐specific proteins and lipids, and spirally wrap axons forming a compact insulating layer in vivo. By analogy with other cell types, maintenance and stability of these processes, as well as the formation of the myelin sheath, likely rely on a pronounced cytoskeleton consisting of microtubules and microfilaments. While the specialized process of wrapping and compaction forming the myelin sheath is not well understood, considerably more is known about how cytoskeletal organization is mediated by extracellular and intracellular signals and other interaction partners during oligodendrocyte differentiation and myelination. Here, we review the current state of knowledge on the role of the oligodendrocyte cytoskeleton in differentiation with an emphasis on signal transduction mechanisms and will attempt to draw out implications for its significance in myelination. © 2009 Wiley‐Liss, Inc.
Impact of interchange fees on a nonsaturated multi‐agent payment card market
Authors: Alexandrova‐Kabadjova Biliana 
Published: May 2009

AbstractThe impact that the level of interchange fees has on the payment adoption rate in a non‐saturated market is investigated. This study is performed under different degrees of consumers' and merchants' awareness of the benefits arriving from the network externalities. In a four‐party scheme, we model explicitly the interactions between consumers and merchants at the point of sale. The interchange fees flow from the acquirers to issuers. We allow card issuers to charge consumers with fixed fees and provide net benefits from card usage, whereas acquirers could charge fixed and transactional fees to the merchants. Merchant's transactional fees are determined proportionally to the level of interchange fees. We establish that, under this scheme, the two‐sided nature of the market leads to higher adoption rates with lower interchange fees. Copyright © 2009 John Wiley & Sons, Ltd.
Responses to monetary policy shocks in the east and the west of Europe: a comparison
Authors: Jarociński Marek 
Published: May 2009

AbstractThis paper compares impulse responses to monetary policy shocks in the euro area countries before the EMU and in the New Member States (NMS) from central–eastern Europe. We mitigate the small‐sample problem, which is especially acute for the NMS, by using a Bayesian estimation that combines information across countries. The impulse responses in the NMS are broadly similar to those in the euro area countries. There is some evidence that in the NMS, which have had higher and more volatile inflation, the Phillips curve is steeper than in the euro area countries. This finding is consistent with economic theory. Copyright © 2009 John Wiley & Sons, Ltd.
Identification of a direct hemolytic effect dependent on the catalytic activity induced by phospholipase‐D (dermonecrotic toxin) from brown spider venom
Authors: Chaves‐Moreira Daniele , Chaim Olga M. , Sade Youssef B. , Paludo Kátia S. , Gremski Luiza H. , Donatti Lucélia , de Moura Juliana , Mangili Oldemir C. , Gremski Waldemiro , da Silveira Rafael B. , Senff‐Ribeiro Andrea , Veiga Silvio S. 
Published: May 2009

AbstractBrown spiders have world‐wide distribution and are the cause of health problems known as loxoscelism. Necrotic cutaneous lesions surrounding the bites and less intense systemic signs like renal failure, DIC, and hemolysis were observed. We studied molecular mechanism by which recombinant toxin, biochemically characterized as phospholipase‐D, causes direct hemolysis (complement independent). Human erythrocytes treated with toxin showed direct hemolysis in a dose‐dependent and time‐dependent manner, as well as morphological changes in cell size and shape. Erythrocytes from human, rabbit, and sheep were more susceptible than those from horse. Hemolysis was not dependent on ABO group or Rhesus system. Confocal and FACS analyses using antibodies or GFP‐phospholipase‐D protein showed direct toxin binding to erythrocytes membrane. Moreover, toxin‐treated erythrocytes reacted with annexin‐V and showed alterations in their lipid raft profile. Divalent ion chelators significantly inhibited hemolysis evoked by phospholipase‐D, which has magnesium at the catalytic domain. Chelators were more effective than PMSF (serine‐protease inhibitor) that had no effect on hemolysis. By site‐directed mutation at catalytic domain (histidine 12 by alanine), hemolysis and morphologic changes of erythrocytes (but not the toxin's ability of membrane binding) were inhibited, supporting that catalytic activity is involved in hemolysis and cellular alterations but not toxin cell binding. The results provide evidence that L. intermedia venom phospholipase‐D triggers direct human blood cell hemolysis in a catalytic‐dependent manner. J. Cell. Biochem. 107: 655–666, 2009. © 2009 Wiley‐Liss, Inc.
Comparative study of amplification systems in immunoenzyme assays for the diagnosis of American tegumentary leishmaniasis
Authors: Nascimento Lílian Dias , Passos Sonia Regina Lambert , Mouta‐Confort Eliame , de Almeida Santiago Marta , Alves Andreia Silva , de Fátima Madeira Maria , de Oliveira Schubach Armando , de Almeida Marzochi Mauro Célio 
Published: May 2009

AbstractWe compared the accuracy and reliability of three amplification systems for enzyme immunoassays in the detection of specific IgG antibodies for the diagnosis of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in patients from an endemic area in Rio de Janeiro, Brazil. Partially soluble antigens obtained from the promastigote forms of L. (V.) braziliensis were used. For development of the reaction, two chromogens, 1,2‐orthophenylenediamine (OPD) and 3,3′,5,5′‐tetramethylbenzidine (TMB), and a fluorogen, 4‐methylumbelliferylphosphate (MUP), were tested. The performance of each system was compared using the following parameters: accuracy, intraclasscorrelation coefficient (ICC), and area under the receiver operating characteristic (ROC) curve. Sensitivity was the same (97.4%) for all systems. The reliability was excellent (ICC=98.6, 98.7, and 99.1%) and specificity was 93.7, 95.8, and 97.4% for OPD, MUP, and TMB, respectively, showing no statistical significance. Despite the absence of differences in the performance of the three systems, the use of TMB is suggested because of its operational advantages, such as low cost compared with fluorogens, easy manipulation, greater stability, and lower toxicity. J. Clin. Lab. Anal. 23:152–156, 2009. © 2009 Wiley‐Liss, Inc.
Diagnostic efficacy of the ELISA test for the detection of deamidated anti‐gliadin peptide antibodies in the diagnosis and monitoring of celiac disease
Authors: Tonutti Elio , Visentini Daniela , Picierno Alessia , Bizzaro Nicola , Villalta Danilo , Tozzoli Renato , Kodermaz Graziano , Carroccio Antonio , Iacono Giuseppe , Teresi Saverio , Chiusa Stella Maria La , Brusca Ignazio 
Published: May 2009

AbstractBackground and Aim: We evaluated the diagnostic performance of an ELISA test for anti‐gliadin IgA and IgG antibodies, which uses synthetic deamidated gliadin peptides (anti‐gliadin antibodies, AGAs) as coating; the results were compared with a test that uses extracted gliadin (AGAe).Methods: The study was conducted on the sera of 144 patients suffering from celiac disease (CD), including 20 patients with IgA deficiency and 9 who were following a gluten‐free diet (GFD), and 129 controls.Results: In the 115 CD patients (without IgA deficiency), the sensitivity of AGAe IgA and IgG was 32.2 and 60.9%, whereas that of AGAs IgA and IgG was 59.1 and 72.2%. The specificity for AGAe IgA and IgG, and AGAs IgA and IgG was 93.8 and 89.9%, and 96.9% and 99.2%, respectively. Of the 20 patients with CD and IgA deficiency, 7 tested positive for AGAe IgG and 14 for AGAs IgG. The test using deamidated gliadin peptides performed better in terms of sensitivity and specificity than the AGA tests with extracted antigen.Conclusions: The very high specificity of the AGAs IgG test (99.2%) also suggests that patients who test positive with this assay require a thorough followup, even if the anti‐tissue transglutaminase antibodies (anti‐tTG) and anti‐endomysial autoantibodies (EMA) assays are negative. J. Clin. Lab. Anal. 23:165–171, 2009. © 2009 Wiley‐Liss, Inc.
Age‐dependent decreases in serum soluble interleukin‐1 receptor type I (sIL‐1RI) in healthy individuals: a population study of serum sIL‐1RI levels in Japanese subjects
Authors: Okamoto Yoshihiro , Tanaka Mayuri , Miyahara Nobuhiro , Tanabe Mie , Gotoh Yoshimitsu , Nagai Takuhito , Fujita Naoya , Fukui Takashi , Masuzawa Toshiyuki 
Published: May 2009

AbstractThe levels of several soluble cytokine receptors in body fluids of healthy individuals change with age. Clinical application of the measurement of the serum soluble interleukin‐1 receptor type I (sIL‐1RI) level depends critically on the samples used as the controls. At present, there is no information regarding the levels of serum sIL‐1RI in healthy subjects. The purpose of this study is to reveal the age‐related changes that occur in the serum sIL‐1RIlevels of healthy individuals. We determined the serum sIL‐1RI levels of healthy Japanese children using ELISA. The serum sIL‐1RI level of children (0–14 years) was significantly higher than that of adults (more than 15 years) (P=0.0138, n=90). Thus, it is recommended that when the serum sIL‐1RI level of patients is evaluated, it should be compared against age‐matched controls. J. Clin. Lab. Anal. 23:175–178, 2009. © 2009 Wiley‐Liss, Inc.
Simultaneous determination of α‐fetoprotein immune complexes and α‐fetoprotein concentration in hepatocellular carcinoma using dual‐label time‐resolved immunofluorometric assays
Authors: Sheng Shi Le , Wang Qing , Huang Gang , Yu Bin , Qin Wen Xin 
Published: May 2009

Abstractα‐Fetoprotein (AFP) is a commonly used tumor marker in the detection of hepatocellular carcinoma (HCC), and its sensitivity and specificity is insufficient to detect HCC in all patient samples. Recently, the immunocomplexed forms of AFP (AFP‐IgM) have been reported to be present in HCC patients. This study was aimed at developing a novel time‐resolved immunofluorometric assay (TR‐IFMA) for the simultaneous determination of AFP‐IgM and AFP concentration in HCC. We constructed a double‐label assay by using Sm3+‐labeled mAb to human IgM antibody, Eu3+‐labeled mAb to AFP, and immobilized another mAb to AFP on the solid phase. The performances of the assay were all found to be satisfactory. The validity of the novel assay was confirmed by the good correlation between the results obtained by TR‐IFMA and commercial ELISA or electrochemiluminescence immunoassay. AFP‐IgM and AFP were increased above the cutoffs in 65.25 and 45.76% of HCC, respectively. ROC analysis yielded the following area under the curve: AFP‐IgM 0.774 (CI 95% 0.736–0.809), AFP 0.771 (CI 95% 0.733–0.860). The combined use of AFP‐IgM and AFP increased the sensitivity of detection to 72.88% in patients with HCC. These data suggest that the use of a combination of two markers in clinical practice could increase the accuracy of HCC diagnosis. J. Clin. Lab. Anal. 23:179–185, 2009.© 2009 Wiley‐Liss, Inc.
Temperament and character associated with depressive symptoms in women: analysis of two genetically informative samples
Authors: Yuh Jongil , Neiderhiser Jenae M. , Lichtenstein Paul , Hansson Kjell , Cederblad, Marianne , Elthammer Olle , Reiss David 
Published: May 2009

AbstractAlthough previous research has explored associations between personality and depressive symptoms, a limited number of studies have assessed the extent to which genetic and environmental influences explain the association. This study investigated how temperament and character were associated with depressive symptoms in 131 pairs of twin and sibling women in early adulthood, as well as 326 pairs of twin women in middle adulthood. Results indicated that genetic influences accounted for a moderate to substantial percentage of the association between these personality features and depressive symptoms, emphasizing the role of genetic influences. Nonshared environmental influences made important contributions to the association between character and depressive symptoms, particularly in the sample of middle‐aged twin women. These findings suggest that unique social experiences and relationships with a partner in adulthood may play an important role in these associations between character and depressive symptoms. © 2009 Wiley Periodicals, Inc. J Clin Psychol 65: 1–19, 2009.
Belief in a concerned god predicts response to treatment for adults with clinical depression
Authors: Murphy Patricia E. , Fitchett George 
Published: May 2009

AbstractBelief in a concerned God has been shown to be associated with lower depression through the mediation of hopelessness. This study hypothesized that this relationship would also be true longitudinally. Shortly after admission to treatment and 8 weeks later, 136 adults with clinical depression completed the Beck Depression Inventory, the Beck Hopelessness Scale, and the Religious Well‐Being Scale (RWB). Logistic regression models supported an association of baseline RWB, but not baseline hopelessness, with a 50% reduction in symptoms after 8 weeks. Persons in the upper third of RWB at admission were 75% more likely to have a response to treatment than persons in the lower third. Clinicians need to be aware of the role of religion for their clients. © 2009 Wiley Periodicals, Inc. J Clin Psychol 65:1–9, 2009.