bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edible Long‐Afterglow Photoluminescent Materials for Bioimaging
Authors: Shen Shen , Xie Qishan , Sahoo Smruti Ranjan , Jin Jian , Baryshnikov Glib V. , Sun Hao , Wu Hongwei , Ågren Hans , Liu Qingsong , Zhu Liangliang 
Published: May 2024

AbstractConfining luminophores into modified hydrophilic matrices or polymers is a straightforward and widely used approach for afterglow bioimaging. However, the afterglow quantum yield and lifetime of the related material remain unsatisfactory, severely limiting the using effect especially for deep‐tissue time‐resolved imaging. This fact largely stems from the dilemma between material biocompatibility and the quenching effect of water environment. Herein an in situ metathesis promoted doping strategy is presented, namely, mixing ≈10−3 weight ratio of organic‐emitter multicarboxylates with inorganic salt reactants, followed by metathesis reactions to prepare a series of hydrophilic but water‐insoluble organic–inorganic doping afterglow materials. This strategy leads to the formation of edible long‐afterglow photoluminescent materials with superior biocompatibility and excellent bioimaging effect. The phosphorescence quantum yield of the materials can reach dozens of percent (the highest case: 66.24%), together with the photoluminescent lifetime lasting for coupes of seconds. Specifically, a long‐afterglow barium meal formed by coronene salt emitter and BaSO4 matrix is applied into animal experiments by gavage, and bright stomach afterglow imaging is observed by instruments or mobile phone after ceasing the photoexcitation with deep tissue penetration. This strategy allows a flexible dosage of the materials during bioimaging, facilitating the development of real‐time probing and theranostic technology.
Shape‐Versatile Fixed Cellular Materials for Multiple Target Immunomodulation
Authors: Sousa Ana Rita , Cunha Ana F. , Santos‐Coquillat Ana , Estrada Beatriz Hernaez , Spiller Kara L. , Barão Marta , Rodrigues Artur Filipe , Simões Susana , Vilaça Andreia , Ferreira Lino , Oliveira Mariana B. , Mano João F. 
Published: May 2024

AbstractTherapeutic cells are usually administered as living agents, despite the risks of undesired cell migration and acquisition of unpredictable phenotypes. Additionally, most cell‐based therapies rely on the administration of single cells, often associated with rapid in vivo clearance. 3D cellular materials may be useful to prolong the effect of cellular therapies and offer the possibility of creating structural volumetric constructs. Here, the manufacturing of shape‐versatile fixed cell‐based materials with immunomodulatory properties is reported. Living cell aggregates with different shapes (spheres and centimeter‐long fibers) are fixed using a method compatible with maintenance of structural integrity, robustness, and flexibility of 3D constructs. The biological properties of living cells can be modulated before fixation, rendering an in vitro anti‐inflammatory effect toward human macrophages, in line with a decreased activation of the nuclear factor kappa B (NF‐κB) pathway that preponderantly correlated with the surface area of the materials. These findings are further corroborated in vivo in mouse skin wounds. Contact with fixed materials also reduces the proliferation of activated primary T lymphocytes, while promoting regulatory populations. The fixation of cellular constructs is proposed as a versatile phenotypic stabilization method that can be easily implemented to prepare immunomodulatory materials with therapeutic potential.
Diagnosis of Serous Effusion with Intelligent Imaging Flow Cytometry
Authors: Long Mengping , Weng Yueyun , Mei Liye , Yang Dingchao , Wei Shubin , Meng Guanxiong , Zhao Wanyue , Liu Sheng , Wang Du , Liu Yiqiang , Shen Hui , Hou Jianxuan , Xu Yu , Tao Liang , Zhou Fuling , Chen Hongwei , Hu Taobo , Lei Cheng 
Published: May 2024

AbstractA serous effusion is a buildup of extra fluid in the serous cavities including pleural, peritoneal, and pericardial cavities. It is important to distinguish benign reactive effusions from effusions caused by malignant proliferation in cytopathology since different diagnoses can lead to completely different disease staging and therapeutic choices. The conventional cytopathology procedure has the disadvantages of low throughput and low objectivity. To enhance the efficiency and accuracy of malignant serous effusion diagnosis, in this paper, an imaging flow cytometry, called optofluidic time‐stretch microscopy is first employed, to image the cells in the serous effusion at an event rate of 100 000 events per second and with a spatial resolution better than 1 µm. The acquired cellular images are then analyzed using a convolutional neural network, by which the malignant cells are accurately detected. The performance of the method is validated with 18 clinical samples, including 14 malignant and 4 benign ones. The results show that the method can detect malignant cells at an accuracy of 90.53%. The high throughput, high accuracy, and high convenience of the method make it a potential solution for malignant serous effusion diagnosis in various scenarios.
Tuning the Electronic Characteristics of Monolayer MoS2‐Based Transistors by Ion Irradiation: The Role of the Substrate
Authors: Fekri Zahra , Chava Phanish , Hlawacek Gregor , Ghorbani‐Asl Mahdi , Kretschmer Silvan , Awan Wajid , Mootheri Vivek , Venanzi Tommaso , Sycheva Natalia , George Antony , Turchanin Andrey , Watanabe Kenji , Taniguchi Takashi , Helm Manfred , Krasheninnikov Arkady V. , Erbe Artur 
Published: May 2024

AbstractThis study explores defect engineering in 2D materials using ion beam irradiation to modify the electrical and optical properties with potential in advancing quantum electronics and photonics. Helium and neon ions ranging from 5 to 7.5 keV are employed to manipulate charge transport in monolayer molybdenum disulfide (MoS2). In situ electrical characterization occurs without vacuum breakage post‐irradiation. Raman and photoluminescence spectroscopy quantify ion irradiation's impact on MoS2. Small doses of helium ion irradiation enhance monolayer MoS2 conductivity in field‐effect transistor geometry by inducing doping and substrate charging. Findings reveal a strong correlation between the electrical properties of MoS2 and the primary ion used, as well as the substrate on which the irradiation occurred. Using hexagonal boron nitride (h‐BN) as a buffer layer between MoS2 flake and SiO2 substrate yields distinct alterations in electrical behavior subsequent to ion irradiation compared to the MoS2 layer directly interfacing with SiO2. Molecular dynamics simulations and density functional theory provide insight into experimental results, emphasizing substrate influence on measured electrical properties post‐ion irradiation.
Multilayer Metamaterials with Ferromagnetic Domains Separated by Antiferromagnetic Domain Walls
Authors: Salikhov Ruslan , Samad Fabian , Schneider Sebastian , Pohl Darius , Rellinghaus Bernd , Böhm Benny , Ehrler Rico , Lindner Jürgen , Kiselev Nikolai S. , Hellwig Olav 
Published: May 2024

AbstractMagnetic nano‐objects possess great potential for more efficient data processing, storage, and neuromorphic‐type applications. Using high perpendicular magnetic anisotropy synthetic antiferromagnets in the form of multilayer‐based metamaterials, the antiferromagnetic interlayer exchange energy is purposefully reduced below the out‐of‐plane demagnetization energy, which controls magnetic domain formation. In this unusual magnetic energy regime, as demonstrated via macroscopic magnetometry and microscopic Lorentz transmission electron microscopy, it becomes possible to stabilize nanometer‐scale stripe and bubble textures consisting of ferromagnetic out‐of‐plane domain cores separated by antiferromagnetic in‐plane Bloch‐type domain walls. This unique coexistence of mixed ferromagnetic/antiferromagnetic order on the nanometer scale opens so far unexplored perspectives in the architecture of magnetic domain landscapes as well as the design and functionality of individual magnetic textures, such as bubble domains with depth‐wise alternating chirality.
“We are mothers, sisters, and lovers too”: Examining young Black women's experiences navigating sex and sexual health
Authors: Darko Natasha A. , Wilson Ciann L. , Oliver Vanessa 
Published: May 2024

AbstractIn Canada, there is a lack of research that addresses the sexual health and well‐being of African, Caribbean, and Black young women. This paper aims to gather perspectives of young Black women to address the social contexts of how young Black women navigate issues related to sex and sexual health. Young Black women experience unique dynamics in navigating their sexualities and sexual healthcare. The nuanced experiences stem from social contexts with historical underpinnings, such as the perception of Black women's bodies, Black identity, gender roles, and sexual double standards. This Community‐Based Participatory Research study (N = 24) utilized focus groups to examine young Black women's experiences navigating sexual health. Employing a thematic analysis, participants identified four themes representing their narratives of navigating sexual health. The themes included the perceptions and hypersexuality of Black women's bodies, navigating sexual double standards and gender roles as Black women, diverse Blackness, and migration experiences concerning sexual health and surveillance of Black women's bodies. This paper is intended to add to scholarly discourse and will include practical strategies for use by researchers and community practitioners in sexual health within the Black community.
A pilot study to identify factors associated with frailty within the World Trade Center general responder cohort
Authors: Thompson Hannah M. , Thanik Erin , Sabra Ahmad , Ko Fred , Hung William W. , Colicino Elena , Lucchini Roberto G. , Bello Ghalib , Crane Michael , Teitelbaum Susan L. , Ornstein Katherine A. 
Published: May 2024

AbstractBackgroundGiven the significant exposures experienced by the World Trade Center (WTC) general responders, there is increasing interest in understanding the effect of these exposures on aging in this population. We aim to identify factors that may be associated with frailty, a clinical syndrome characterized by a decrease in one's reserve that has been linked to poor health outcomes.MethodsWTC general responders enrolled in the WTC Health Program aged 50 and older provided informed consent. Validated frailty assessments, the Frailty Phenotype (with the Johns Hopkins Frailty Assessment Calculator) along with the FRAIL scale, categorized nonfrail from prefrail/frail. Fall risk, functional status, and cognition were also assessed. WTC variables, including an identified WTC‐certified condition, were utilized. The risk of frailty was estimated using log binomial regression analysis. A 95% confidence interval (CI) was used to estimate the prevalence ratio (PR).ResultsOne hundred and six participants were included; 38 (35.8%) were classified as pre‐frail or frail. More of the pre‐frail/frail group were obese (57.9% vs. 25%; p = 0.004) and had a WTC‐certified condition (78.9% vs. 58.8%; p = 0.036). Obesity (PR = 2.43, 95% CI = 1.31, 4.53), a WTC‐certified condition (PR = 1.77, 95% CI = 1.09, 2.89), and risk of falling (PR = 1.97, 95% CI = 1.01, 3.84) were independently associated with frailty.ConclusionsObesity and having a WTC‐certified condition were found to be risk factors for frailty in our pilot study. Future work may focus on further identifying risk factors for frailty in the larger WTC general responder population.
Filippi syndrome: Three new families suggest that urinary system abnormalities may belong to clinical spectrum of the disease
Authors: Bas Hasan , Durmaz Ceren Damla , Tombak Merve Celenkoglu , Cetin Gokhan Ozan , Karaer Kadri 
Published: May 2024

AbstractFilippi syndrome is a rare genetic disorder characterized by growth and neurodevelopmental delays, dysmorphism, and selective limb abnormalities. Although the syndrome was described approximately four decades ago, only a few families with molecularly confirmed diagnoses have been reported. In this article, we present three new patients of Filippi syndrome with unusual clinical and genetic aspects. These patients exhibited novel clinical features that have not previously been associated with Filippi syndrome, including renal hypoplasia/aplasia, renal cysts, renal cortical thinning, hypomelanotic, and hypermelanotic macules. All three patients had homozygous frameshift variants of the CKAP2L gene, specifically NM_152515.3: c.554_555del, c.981_982del, and c.1463_1467del, with the second being a novel variant. Given the limited number of reported Filippi syndrome patients to date and the ongoing discovery of new clinical aspects of the disease, exploring its potential connection with kidney and skin pigmentation abnormalities could be valuable for future research.
Surgical management of headache and facial pain/pressure in chronic rhinosinusitis: A systematic review and meta‐analysis
Authors: Heiland Luke D. , Marrero‐Gonzalez Alejandro R. , Nguyen Shaun A. , Farmer Hannah G. , Rathi Vinay K. , Soler Zachary M. , Schlosser Rodney J. 
Published: May 2024

AbstractBackgroundHeadache and facial pain are common symptoms of chronic rhinosinusitis (CRS). However, given the numerous etiologies that can cause these symptoms, the impact of sinus surgery is not well characterized.MethodsA systematic review was performed by searching the literature from inception through June 6, 2023. English‐language articles reporting outcomes for facial pain/pressure or headache following endoscopic sinus surgery were selected for inclusion. Meta‐analyses were performed using random and fixed effect models on continuous measures (mean), mean difference (Δ), and proportions (%).ResultsA total of 26 articles reporting on 2839 patients were selected for inclusion. The mean patient age was 44.0 ± 3.9 (range 16.0–84.0), with an average symptom duration of 5.3 ± 2.8 years. Among these patients, 56.5% (95% confidence interval [CI]: 52.3–60.6) were male and 77.0% (95% CI: 56.6–92.3) had nasal polyposis (NP). Patients with and without NP reported substantial reductions in both 22‐item sino‐nasal outcome test facial pain/pressure (with NP: −1.4 [95% CI: −1.6 to −1.2; relative reduction 59.1%]; without NP: −1.5 [95% CI: −1.9 to −1.1; relative reduction 60.9%]) and visual analogue scale (VAS) headache (with NP: −2.5 [95% CI: −2.8 to −2.1; relative reduction 67.2%]; without NP: −2.8 [95% CI: −4.7 to −1.0; relative reduction 42.7%]). Symptom reductions were greater in the without NP versus with NP group; VAS facial pain/pressure: Δ0.4 (95% CI: 0.2–0.6; p = 0.0006) and VAS headache: Δ0.4 (95% CI: 0.1–0.7; p = 0.02).ConclusionsOur findings suggest that CRS patients, regardless of polyp status, benefit from significant reductions in facial pain/pressure and headache following surgical therapy.
Reverse Separation of Carbon Dioxide and Acetylene in Two Isostructural Copper Pyridine‐Carboxylate Frameworks
Authors: Li Jing‐Hong , Gan You‐Wei , Chen Jun‐Xian , Lin Rui‐Biao , Yang Yisi , Wu Hui , Zhou Wei , Chen Banglin , Chen Xiao‐Ming 
Published: May 2024

AbstractSeparating acetylene from carbon dioxide is important but highly challenging due to their similar molecular shapes and physical properties. Adsorptive separation of carbon dioxide from acetylene can directly produce pure acetylene but is hardly realized because of relatively polarizable acetylene binds more strongly. Here, we reverse the CO2 and C2H2 separation by adjusting the pore structures in two isoreticular ultramicroporous metal–organic frameworks (MOFs). Under ambient conditions, copper isonicotinate (Cu(ina)2), with relatively large pore channels shows C2H2‐selective adsorption with a C2H2/CO2 selectivity of 3.4, whereas its smaller‐pore analogue, copper quinoline‐5‐carboxylate (Cu(Qc)2) shows an inverse CO2/C2H2 selectivity of 5.6. Cu(Qc)2 shows compact pore space that well matches the optimal orientation of CO2 but is not compatible for C2H2. Neutron powder diffraction experiments confirmed that CO2 molecules adopt preferential orientation along the pore channels during adsorption binding, whereas C2H2 molecules bind in an opposite fashion with distorted configurations due to their opposite quadrupole moments. Dynamic breakthrough experiments have validated the separation performance of Cu(Qc)2 for CO2/C2H2 separation.
A General Iron‐Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids
Authors: Denkler Luca Mareen , Aladahalli Shekar Meghana , Ngan Tak Shing Jason , Wylie Luke , Abdullin Dinar , Engeser Marianne , Schnakenburg Gregor , Hett Tobias , Pilz Frank Hendrik , Kirchner Barbara , Schiemann Olav , Kielb Patrycja , Bunescu Ala 
Published: May 2024

AbstractWe report an iron‐catalyzed decarboxylative C(sp3)−O bond‐forming reaction under mild, base‐free conditions with visible light irradiation. The transformation uses readily available and structurally diverse carboxylic acids, iron photocatalyst, and 2,2,6,6‐tetramethylpiperidine 1‐oxyl (TEMPO) derivatives as oxygenation reagents. The process exhibits a broad scope in acids possessing a wide range of stereoelectronic properties and functional groups. The developed reaction was applied to late‐stage oxygenation of a series of bio‐active molecules. The reaction leverages the ability of iron complexes to generate carbon‐centered radicals directly from carboxylic acids by photoinduced carboxylate‐to‐iron charge transfer. Kinetic, electrochemical, EPR, UV/Vis, HRMS, and DFT studies revealed that TEMPO has a triple role in the reaction: as an oxygenation reagent, an oxidant to turn over the Fe‐catalyst, and an internal base for the carboxylic acid deprotonation. The obtained TEMPO adducts represent versatile synthetic intermediates that were further engaged in C−C and C‐heteroatom bond‐forming reactions using commercial organo‐photocatalysts and nucleophilic reagents.
Eine Alkin‐verbrückte kovalent organische Gerüstverbindung mit interaktiven Bindungstaschen für das Einfangen von Brom
Authors: De Ankita , Haldar Sattwick , Schmidt Johannes , Amirjalayer Saeed , Reichmayr Fanny , Lopatik Nikolaj , Shupletsov Leonid , Brunner Eike , Weidinger Inez M. , Schneemann Andreas 
Published: May 2024

AbstractDie hohe Korrosivität und Reaktivität von Brom, welches aus verschiedenen Quellen freigesetzt wird, stellt eine ernsthafte Gefahr für die Umwelt dar. Darüber hinaus erfordert seine Koexistenz mit Iod und die daraus resultierende Gleichgewichtsverbindung Iodmonobromid (IBr) die selektive Abtrennung von Brom aus Halogengemischen. Die Elektrophilie von Halogenen gegenüber π‐elektronenreichen Strukturen ermöglichte uns die strategische Entwicklung einer kovalent organischen Gerüstverbindung für die Halogenaufnahme, die eine definierte Porenumgebung mit lokalisierten Sorptionsstellen aufweist. Die um ~41 % höhere Aufnahmekapazität von Brom (4,6 g g−1) gegenüber Iod zeigt das Potenzial für die selektive Aufnahme. Die spektroskopischen Ergebnisse, welche die bevorzugten Wechselwirkungsstellen aufzeigen, werden durch theoretische Untersuchungen gestützt. Die Alkin‐Brücke ist eine Kernfunktionalität, die die Selektivität bei der Aufnahme durch synergistische Physisorption fördert, was durch die höhere Orbitalüberlappung von Brom aufgrund seiner geringeren atomaren Größe, sowie durch reversible chemische Wechselwirkungen begründet ist. Das sogenannte „slip stacking“ in der Struktur hat dieses Phänomen weiter gefördert, indem Cluster molekularer Interaktionsstellen mit zwischen den Schichten eingelagertem Brom geschaffen wurden. Die Einführung ungesättigter Einheiten, d. h. Dreifachbindungen, und die komplementäre Porengeometrie bieten eine vielversprechende Designstrategie für die Konstruktion poröser Materialien für die Halogenaufnahme.
Dynamic Near‐Infrared Circularly Polarized Luminescence Encoded by Transient Supramolecular Chiral Assemblies
Authors: Wang Qian , Xu Hanren , Qi Zhen , Mei Ju , Tian He , Qu Da‐Hui 
Published: May 2024

AbstractCircularly polarized luminescence (CPL) is promising for applications in many fields. However, most systems involving CPL are within the visible range; near‐infrared (NIR) CPL‐active materials, especially those that exhibit high glum values and can be controlled spatially and temporally, are rare. Herein, dynamic NIR‐CPL with a glum value of 2.5×10−2 was achieved through supramolecular coassembly and energy‐transfer strategies. The chiral assemblies formed by the coassembly between adenosine triphosphate (ATP) and a pyrene derivative exhibited a red CPL signal (glum of 10−3). The further introduction of sulfo‐cyanine5 resulted in a energy‐transfer process, which not only led to the NIR CPL but also increased the glum value to 10−2. Temporal control of these chiral assemblies was realized by introducing alkaline phosphatase to fabricate a biomimetic enzyme‐catalyzed network, allowing the dynamic NIR CPL signal to be turned on. Based on these enzyme‐regulated temporally controllable dynamic CPL‐active chiral assemblies, a multilevel information encryption system was further developed. This study provides a pioneering example for the construction of dynamic NIR CPL materials with the ability to perform temporal control via the supramolecular assembly strategy, which is expected to aid in the design of supramolecular complex systems that more closely resemble natural biological systems.
Designing Dual‐Site Catalysts for Selectively Converting CO2 into Methanol
Authors: Cui Wenjie , Wang Fei , Wang Xiao , Li Yuou , Wang Xiaomei , Shi Yi , Song Shuyan , Zhang Hongjie 
Published: May 2024

AbstractThe variability of CO2 hydrogenation reaction demands new potential strategies to regulate the fine structure of the catalysts for optimizing the reaction pathways. Herein, we report a dual‐site strategy to boost the catalytic efficiency of CO2‐to‐methanol conversion. A new descriptor, τ, was initially established for screening the promising candidates with low‐temperature activation capability of CO2, and sequentially a high‐performance catalyst was fabricated centred with oxophilic Mo single atoms, who was further decorated with Pt nanoparticles. In CO2 hydrogenation, the obtained dual‐site catalysts possess a remarkably‐improved methanol generation rate (0.27 mmol gcat.−1 h−1). For comparison, the singe‐site Mo and Pt‐based catalysts can only produce ethanol and formate acid at a relatively low reaction rate (0.11 mmol gcat.−1 h−1 for ethanol and 0.034 mmol gcat.−1 h−1 for formate acid), respectively. Mechanism studies indicate that the introduction of Pt species could create an active hydrogen‐rich environment, leading to the alterations of the adsorption configuration and conversion pathways of the *OCH2 intermediates on Mo sites. As a result, the catalytic selectivity was successfully switched.