bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization for bilevel spatial configuration of underground space surrounding high-speed railway station in China from the perspective of urban morphology
Authors: Du Y , Dong Y H , Wang P , Peng F L 
Published: May 2024

Abstract
The rapid growth of high-speed railways has led to the development of underground spaces surrounding high-speed railway stations (USSHRSs). The evolution of USSHRS has enhanced the space utilization efficiency. As USSHRSs expand, the layout of the underground connectivity network becomes increasingly intricate. Additionally, pedestrian behavior in USSHRSs transitions from mere passing to longer stays, and its spatial configuration becomes more difficult to evaluate. To date, studies have mostly focused on the structural analysis or inner underground space relationship of USSHRSs. A research gap exists in the field of USSHRS spatial configuration from the perspective of urban development. To fill this research gap, this study focused on the spatial configuration of the USSHRS from the perspective of urban morphology and established a quantitative analysis method for USSHRSs at both global and local levels. At the global level, we devised a method for measuring the USSHRS spatial configuration using pedestrian composite accessibility based on a complex network. At the local level, we used space syntax to study the inner spatial configuration problems of USSHRSs. Finally, we used the Shanghai Hongqiao Station (Shanghai, China) as a case study. The results revealed that the spatial configuration optimization of the USSHRS must improve the connectivity efficiency of the USSHRS, and the corresponding functional layout should also be optimized towards a centralized layout. This study aims to provide decision-making support for the planning and layout of complicated USSHRS and to highlight the role of USSHRS in urban sustainable development.
Holding capacity of suction anchors under combined loading
Authors: Wang Yufei , Petter Jostad Hans , Zhou Zefeng 
Published: May 2024

Abstract
This paper introduces a numerical investigation aimed at evaluating the Vertical, Horizontal, and Moment (VHM) yield surface of suction anchors. It employs a generalized elliptical function guided by a predefined fitting strategy. The resulting yield surfaces are then juxtaposed with findings from previous studies, establishing the groundwork for the macro model of suction anchors in clay. This model plays a pivotal role in the integrated analysis of mooring systems for floating wind turbines.
The pull-out capacity of torpedo anchor in clay considering the full opening cavity
Authors: Tang C , Wu XN , Chen JJ , Wang T , Shu J 
Published: May 2024

Abstract
Torpedo anchors are increasingly being considered for mooring floating facilities in deep waters owing to their efficient and economical installation. The anchor was released from a specified height above the seabed to allow it to gain velocity as it fell freely into the water before penetrating the seabed. A cavity was formed above the anchor shaft after the anchor installation. The formation of this post-installation cavity is largely dependent on the soil strength conditions and affects the anchor capacity after installation. However, there is a lack of understanding regarding the formation mechanisms of the cavity and its effect on the bearing capacity of a torpedo anchor. Thus, this study focuses on the effects of the post-installation cavity on the bearing capacity of the torpedo anchor. The impact of a fully open post-penetration cavity on both the vertical and inclined bearing capacity of a torpedo anchor without fins was investigated using the Coupled Eulerian–Lagrangian (CEL) method in ABAQUS with three-dimensional large deformation finite element (LDFE) analysis. A method for evaluating the vertical bearing capacity of a torpedo anchor, considering the effect of a post-installation cavity, was proposed. This study provides insight into the installation effect on the bearing capacity of torpedo anchors.
New method for incorporating foundation damping in time-domain analysis of integrated offshore wind turbine structures
Authors: Guo P , Zhang Y , Bi Q , Di T 
Published: May 2024

Abstract
Foundation damping has significant potential for reducing the loads of monopile-supported offshore wind turbines. However, the contribution of foundation damping is not well understood, primarily because of the absence of suitable methods for incorporating it into the time-domain analysis of wind turbine structures. This paper presents a novel approach for this purpose. In this approach, a dashpot is attached parallel to each of the p-y springs along a monopile, which models the stiffness and damping of soil-pile interactions. Employing this approach, the influence of foundation damping on the structural dynamic response is investigated using the time-domain analysis of a monopile-supported IEA 15 MW reference wind turbine. The results demonstrate that foundation damping has a limited impact on the overall dynamic response and fatigue loads of wind turbines during power production. However, the foundation fatigue loads after an emergency shutdown can be reduced by 29-46% owing to the inclusion of foundation damping. In addition, foundation damping is found to significantly influence the bending moment, horizontal displacement, and angular rotation of the monopile at the mudline under parked conditions, with load reductions of up to 20%.
Wavelength calibration and spectral analysis of vacuum ultraviolet spectroscopy in EAST
Authors: JI 计 Huajian 华健 , ZHANG 张 Hongming 洪明 , LYU 吕 Bo 波 , BAE Cheonho , HE 何 Liang 梁 , LIN 林 Zichao 子超 , YIN 尹 Xianghui 相辉 , SHEN 沈 Yongcai 永才 , DAI 戴 Shuyu 舒宇 
Published: May 2024

Abstract
A vacuum ultraviolet (VUV) spectroscopy with a focal length of 1 m has been engineered specifically for observing edge impurity emissions in Experimental Advanced Superconducting Tokamak (EAST). In this study, wavelength calibration for the VUV spectroscopy is achieved utilizing a zinc lamp. The grating angle and charge-coupled device (CCD) position are carefully calibrated for different wavelength positions. The wavelength calibration of the VUV spectroscopy is crucial for improving the accuracy of impurity spectral data, and is required to identify more impurity spectral lines for impurity transport research. Impurity spectra of EAST plasmas have also been obtained in the wavelength range of 50–300 nm with relatively high spectral resolution. It is found that the impurity emissions in the edge region are still dominated by low-Z impurities, such as carbon, oxygen, and nitrogen, albeit with the application of full-tungsten divertors on the EAST tokamak.
Prevalence, sociodemographic, and clinical correlates of underweight in a sample of Chinese male alcohol-dependent patients
Authors: Li Huanfen , Zhu Lifang , Zhang Jie , Xue Jun 
Published: May 2024

Abstract

Background
Underweight is a significant symptom in alcohol-dependent patients, yet few studies have examined underweight in Chinese male patients. The current study aimed to identify the prevalence, sociodemographic, and clinical correlates of underweight in Chinese male patients with alcohol dependency.

Methods
In this cross-sectional study, 405 male inpatients with alcohol dependence and 383 healthy male controls were recruited. Participants’ demographic and clinical data, including anthropometric data, were collected. We first conducted univariate analysis to identify seven variables with significant differences between groups: smoking behavior, hospitalization, alcohol consumption, cerebral infarction, hypertension, Hamilton Depression Scale (HAMD) score, and Scale for Assessment of Negative Symptom (SANS) score. Then, binary logistic regression was used to assess their relationship with underweight, with a significance level of .05.

Results
The prevalence of underweight was significantly higher in the study population than in the control group (2.99% vs. 2.87%; P &lt; .001). Patients with underweight had significantly higher rates of smoking behavior and cerebral infarction, as well as higher scores of SANS and HAMD than non-underweight patients. The non-underweight patients had higher daily alcohol consumption and times of hospitalization. Furthermore, logistic regression analysis showed that smoking behavior [odds ratio (OR) = 2.84, 95% confidence interval (CI) = 1.03–7.80, P = .043)], cerebral infarction (OR = 5.20, 95% CI = 1.13–23.85, P = .036), SANS score (OR = 1.22, 95% CI = 1.16–1.28, P &lt; .001), and HAMD score (OR = 1.06, 95% CI = 1.02–1.11, P = .005) were associated with underweight.

Conclusions
More than 20% of male alcohol-dependent patients in a Chinese sample were underweight. Some demographic and clinical variables independent correlates for underweight in alcohol-dependent patients. We need to focus on alcohol-dependent patients with smoking, cerebral infarction, depression, and more prominent negative symptoms.
Prevalence, incidence, mortality and healthcare resource use for generalized pustular psoriasis, palmoplantar pustulosis and plaque psoriasis in England: a population-based cohort study
Authors: Frysz Monika , Patel Smit , Li Marie Oy Yee , Griffiths Christopher E M , Warren Richard B , Ashcroft Darren M 
Published: May 2024

Abstract

Background
Generalized pustular psoriasis (GPP) and palmoplantar pustulosis (PPP) are chronic inflammatory skin conditions. Accumulating evidence shows that GPP and PPP have different characteristics to plaque psoriasis and are distinct clinical entities.

Objectives
To assess the epidemiology, comorbidities, mortality and healthcare use for patients in England with GPP and PPP versus those with plaque psoriasis.

Methods
We carried out a cohort study involving analyses of longitudinal electronic health record data in the Clinical Practice Research Datalink Aurum database and linked hospital and mortality data between 2008 and 2019. The primary study outcome was the incidence and prevalence rates of GPP, PPP and plaque psoriasis in England. Secondary outcomes included survival rates and healthcare resource use (HCRU) by disease type.

Results
We identified 373 patients with GPP, 1828 with PPP and 224 223 with plaque psoriasis. Mean (SD) age was 55.9 (18.6) years for patients with GPP, 51.5 (16.4) years for those with PPP and 48.5 (19.1) years for those with plaque psoriasis; 62.5% and 65.9% of patients with GPP and PPP, respectively, were women, vs. 49.4% of those with plaque psoriasis. About half of patients were overweight or obese at baseline (GPP 48.6%, PPP 56.0%, plaque psoriasis 45.9%). The incidence rates for GPP, PPP and plaque psoriasis were 0.25 [95% confidence interval (CI) 0.21–0.28], 2.01 (95% CI 1.92–2.11) and 103.2 (95% CI 102.5–103.9) per 100 000 person-years, respectively. From 2008 to 2019, the prevalence rates per 100 000 persons ranged from 1.61 to 3.0 for GPP, from 1.1 to 18.7 for PPP and from 1771.0 to 1903.8 for plaque psoriasis. Survival rates were lower for patients with GPP, particularly those who were &gt; 55 years of age and those with a history of one or more comorbidities in each cohort. HCRU was lower in the cohort with plaque psoriasis and highest in the cohort with GPP, particularly among those who had more than one GPP flare.

Conclusions
Our results provide further evidence that, in England, GPP is a distinct disease with different epidemiology, lower survival and higher HCRU than plaque psoriasis.
Efficacy and safety of irreversible electroporation in unresectable perihilar cholangiocarcinoma: a systematic review and meta-analysis
Authors: Scrofani Anna Rita , Valvano Marco , Lancellotta Valentina , Pezzulla Donato , Vinci Antonio , Cornacchione Patrizia , Bonome Paolo , Tagliaferri Luca , Iezzi Roberto 
Published: May 2024

Abstract

Objectives
The prognosis of patients with perihilar-cholangiocarcinoma (PHC) is poor, with the majority presenting with unresectable disease at diagnosis. Palliative chemotherapy (CHT) is the standard treatment for unresectable PHC. Irreversible electroporation (IRE) has been introduced as a novel ablation technique, working predominantly nonthermal. This review aims to analyse the efficacy and safety of IRE in treating unresectable PHC.

Methods
This systematic review and meta-analysis was performed according to a specific protocol designed a priori, and reported according to the PRISMA. PubMed/MEDLINE, Scopus, and Cochrane CENTRAL were searched up to December 2023. Primary Outcome of interest of our meta-analysis was the mean Overall Survival (OS). Secondary outcomes were progression-free survival (PFS) and adverse event rate (AE).

Results
The mean OS was estimated at 25.49 months (CI, 21.47-38.72, I2 81.37%), PFS 17.86 (CI, 13.00-22.72, I2 11.42%), with an AE incidence of 12% (CI, 7%-31%, I2 83.57%). High heterogeneity was found among studies, with no single study fully responsible for it, suggesting high variability among facilities/populations.

Conclusion
IRE is effective and relatively safe for unresectable PHC. However, the lack of prospective studies and randomized trials comparing chemotherapy or locoregional treatment with IRE prevents drawing sufficiently robust conclusions.

Advances in knowledge
IRE appears a safe and effective technique for treating unresectable perihilar cholangiocarcinoma.
129 PARATHYROID GLAND IDENTIFICATION AND ANGIOGRAPHY CLASSIFICATION USING SIMPLE MACHINE LEARNING METHODS
Authors: Mc Entee P D , Greevy J E , Triponez F , Demarchi M S , Cahill R A 
Published: May 2024

Abstract

Background
Near-infrared indocyanine green (ICG) angiography allows experienced surgeons reliably discern parathyroid gland (PG) vitality during thyroid and parathyroid operations and so predict post-operative function. To facilitate all surgeons perform similarly, we developed an automatic computational quantification method using computer vision that accurately portrays expert interpretation of visualised PG ICG angiographic fluorescence signals.

Methods
ICG-PG angiography video recordings (Fluobeam® LX, Fluoptics, Grenoble – part of Getinge - Göteborg) from patients undergoing endocrine cervical surgery in a high-volume unit were used developmentally. Computation (Matlab, Mathworks, Ireland) included segmentation-identification of PG (by autofluorescence), image stabilisation (by linear translation) and adjusted time-fluorescence intensity profile (TFIP) generation. Relative upslope and maximum intensity ratios then trained a simple logistic regression model grounded in expert interpretation and outcome (including hypoparathyroidism), with unseen testing subsequently.

Results
The model was trained on 37 patient videos (45 glands, 29 judged well perfused by PG angiography experts), achieving feature data separation with 100% accuracy, and tested on 22 unseen videos (27 glands, 15 judged well perfused), including four live in-theatre. Segmentation-guided PG detection correctly identified all PGs during unseen testing along with three additional non-PG regions (90% positive predictive value). Subsequent TFIP extraction with vitality prediction proved feasible in all cases within five minutes, with 96.3% model prediction accuracy (sensitivity/specificity = 93.3/100% respectively) versus expert judgement.

Conclusions
Automatic PG perfusion quantification with simple machine learning computational methods discriminates PG perfusion concordant with expert surgeon interpretation, providing too a means for ICG-PG signal documentation.
152 QUALITY OF LIFE IN PATIENTS WITH PERMANENT HYPOPARATHYROIDISM AFTER THYROIDECTOMY FOR BENIGN THYROID DISEASE: A POPULATION-BASED STUDY WITH LONG-TERM FOLLOW UP
Authors: Annebäck M , Wachtmeister S , Hedberg J , Stålberg P , Norlén O 
Published: May 2024

Abstract

Background
In recent years, several studies have shown that permanent hypoparathyroidism has a negative impact on health-related quality of life (HRQoL). However, these results could have been affected by short-term follow up, selection bias and confounding factors. The aim of this study was to investigate HRQoL in patients with and without permanent hypoparathyroidism after total thyroidectomy for benign thyroid disease, using a strict definition of permanent hypoparathyroidism and long-term follow up data.

Methods
All patients who underwent total thyroidectomy in a region of Sweden between 2005 and 2015 were assessed for eligibility. All eligible patients were invited to participate in the study through a letter on August 2021. SF-36 v2 was used to compare HRQoL in patients with and without permanent hypoparathyroidism.

Results
Out of 1636 patients, 1483 patients were invited to participate in the study. In total, 716 (48,3%) patients answered the SF-36 v2 questionnaire and were included in the study cohort. Mean follow-up was 10.9 (SD ±3.2) years. Patients with and without permanent hypoparathyroidism did not differ in baseline characteristics, with the exception that patients with permanent hypoparathyroidism were younger. There were no evident differences in HRQoL between the two groups, encompassing all health domains and summary component scores. (p&gt;0.05).

Conclusions
No difference in HRQoL was found when comparing patients with and without permanent hypoparathyroidism after total thyroidectomy for benign thyroid disease on long-term follow up. These results challenge previous findings and underscore the importance of comprehensive, long-term investigations, calling for a more nuanced understanding of the condition’s effects on HRQoL.
Stability-Indicating TLC-Densitometric and HPLC Methods for Simultaneous Determination of Teneligliptin and Pioglitazone in Pharmaceutical Dosage Forms with Eco-Friendly Assessment
Authors: Akabari Ashok H , Gajiwala Harsh , Patel Sagarkumar K , Surati Jasmina , Solanki Divya , Shah Ketan V , Patel Tejas J , Patel Sagar P 
Published: May 2024

Abstract
The combination of teneligliptin hydrobromide hydrate and pioglitazone hydrochloride in pharmaceutical formulations has improved type 2 diabetes management. Two chromatographic methods TLC-densitometry and RP-HPLC were developed for simultaneous quantification of teneligliptin hydrobromide hydrate and pioglitazone hydrochloride in pharmaceutical formulations, ensuring accuracy and stability assessment. The TLC method uses a mobile phase of methanol, toluene, ethyl acetate and triethylamine (1:7:2:0.1, v/v/v/v) on TLC silica gel plates, scanned at 268 nm. The RP-HPLC method employs isocratic elution with acetonitrile and sodium acetate buffer (adjust pH 3.6 with glacial acetic acid, 60:40 v/v) on a shimpack C18 column (250 × 4.6 mm i.d., 5 μm), detected at 235 nm. Both methods offer high accuracy and reliability, making them valuable for pharmaceutical quality control. Additionally, an environmental impact assessment was conducted using eco-scale, Analytical Greenness Metric Approach, Green Analytical Procedure Index, and national environmental method index to evaluate solvent consumption, waste generation and energy usage. Statistical comparisons (t-tests and F-tests) validate the outcomes of both methods, ensuring their effectiveness in drug formulation analysis. These methods can enhance pharmaceutical quality control while fulfilling environmental responsibilities.
Facial vascular visualization enhancement based on optical detection technology
Authors: Liu Kai , Li Kai , Wang Xudong , Sun Jiuai , Shen Steve G F 
Published: May 2024

Abstract

Objective
This study aims to develop a facial vascular enhancement imaging system and analyze vascular distribution in the facial region to assess its potential in preventing unintended intravascular injections during cosmetic facial filling procedures.

Methods
A facial vascular enhancement imaging system based on optical detection technology was designed, and volunteers were recruited. The system was utilized to detect and analyze vascular distribution in various anatomical regions of the faces. The vascular visualization-enhanced (VVE) images generated by the system were compared with visible light images to validate the vascular visualization capability of the system. Additionally, the reliability of vascular visualization was assessed by comparing the observed vascular patterns in the VVE images with those in near-infrared light images.

Results
Thirty volunteers were recruited. The VVE images produced by the system demonstrated a significant capacity to identify vascular morphology and yielded a higher vessel count compared to visible light images, particularly in the frontal, orbital, perioral, mental, temporal, cheek, and parotid masseter regions (P &lt; .05). The temporal region exhibited the highest vascular density, followed by the cheek region and then the frontal region. Reliability analysis of vascular visualization enhancement indicated that the system’s imaging of facial vasculature not only demonstrated reliability but also enhanced physicians’ visual perception.

Conclusion
Blood vessel distribution varies across facial regions. The facial vascular enhancement imaging system facilitates real-time and clear visualization of facial vasculature, offering immediate visual feedback to surgeons. This innovation holds promise for enhancing the safety and effectiveness of facial filling procedures.
Prevalence and determinants of low QRS voltages and QRS fragmentation in children and adolescents undergoing sports pre-participation screening
Authors: Graziano Francesca , Genta Oscar Edoardo , Manfrin Laura , Corrado Domenico , Brusamolin Laura , Giada Franco , Gerbino Luigi , Compagno Silvia , Zorzi Alessandro 
Published: May 2024

Abstract

Aims
Low QRS voltages (LQRSV) in limb leads and QRS fragmentation (FQRS) are possible electrocardiographic signs of myocardial fibrosis and cardiomyopathy, but they are not listed in current criteria for interpreting athlete’s electrocardiogram (ECG). We investigated the prevalence and determinants of LQRSV and FQRS in a cohort of young apparently healthy athletes undergoing pre-participation screening (PPS).

Methods and results
We analysed a consecutive series of 2140 ECG obtained during PPS of young athletes (mean age 12.5 ± 2.6 years, 7–18-year-old, 49% males). The peak-to-peak QRS voltage was measured in all limb leads, and LQRSV were defined when maximum value was &lt;0.5 mV. Fragmented QRS morphologies were grouped into five patterns. Lead aVR was not considered. Maximum peak-to-peak QRS voltage in limb leads was 1.4 ± 0.4 mV, similar between younger and older athletes, but significantly lower in females than males (1.35 ± 0.38 mV vs. 1.45 ± 0.42 mV; P &lt; 0.001). There was a weak correlation between maximal QRS voltages and body mass index (BMI), but not with type of sport or training load. Only five (0.2%) individuals showed LQRSV. At least one fragmented QRS complex was identified in 831 (39%) individuals but excluding the rSr′ pattern in V1–V2, only 10 (0.5%) showed FQRS in ≥2 contiguous leads. They were older than those without FQRS, but did not differ in terms of gender, BMI, type of sport, or training load.

Conclusion
Low QRS voltages in limb leads and FQRS in ≥2 contiguous leads excluding V1–V2 are rare in young apparently healthy athletes and are not related to the type and intensity of sport activity. Therefore, they may require additional testing to rule out an underlying disease particularly when other abnormalities are present.