bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial
Authors: Lannering Birgitta , Rutkowski Stefan , Doz Francois , Pizer Barry , Gustafsson Göran , Navajas Aurora , Massimino Maura , Reddingius Roel , Benesch Martin , Carrie Christian , Taylor Roger , Gandola Lorenza , Björk-Eriksson Thomas , Giralt Jordi , Oldenburger Foppe , Pietsch Torsten , Figarella-Branger Dominique , Robson Keith , Forni Marco , Clifford Steven C. , Warmuth-Metz Monica , von Hoff Katja , Faldum Andreas , Mosseri Véronique , Kortmann Rolf 
Published: July 2012

Purpose To compare event-free survival (EFS), overall survival (OS), pattern of relapse, and hearing loss in children with standard-risk medulloblastoma treated by postoperative hyperfractionated or conventionally fractionated radiotherapy followed by maintenance chemotherapy. Patients and Methods In all, 340 children age 4 to 21 years from 122 European centers were postoperatively staged and randomly assigned to treatment with hyperfractionated radiotherapy (HFRT) or standard (conventional) fractionated radiotherapy (STRT) followed by a common chemotherapy regimen consisting of eight cycles of cisplatin, lomustine, and vincristine. Results After a median follow-up of 4.8 years (range, 0.1 to 8.3 years), survival rates were not significantly different between the two treatment arms: 5-year EFS was 77% ± 4% in the STRT group and 78% ± 4% in the HFRT group; corresponding 5-year OS was 87% ± 3% and 85% ± 3%, respectively. A postoperative residual tumor of more than 1.5 cm2 was the strongest negative prognostic factor. EFS of children with all reference assessments and no large residual tumor was 82% ± 2% at 5 years. Patients with a delay of more than 7 weeks to the start of RT had a worse prognosis. Severe hearing loss was not significantly different for the two treatment arms at follow-up. Conclusion In this large randomized European study, which enrolled patients with standard-risk medulloblastoma from more than 100 centers, excellent survival rates were achieved in patients without a large postoperative residual tumor and without RT treatment delays. EFS and OS for HFRT was not superior to STRT, which therefore remains standard of care in this disease.
Synthesis, Crystal Structure, and Properties of a New Lead Barium Borate, Pb1.13Ba7.87B18O36
Authors: Wu Hongping , Pan Shilie , Jia Dianzeng , Chen Zhaohui , Yu Hongwei 
Published: July 2012

Abstract
A new compound, Pb1.13Ba7.87B18O36, has been synthesized by a solid-state reaction, and its structure was determined by single-crystal X-ray diffraction. It crystallizes in the non-centrosymmetric space group R32. The fundamental building units of Pb1.13Ba7.87B18O36 are the hexagonal B3O6 rings, which are parallel to the (001) plane and stack along the c axis. Pb1.13Ba7.87B18O36 exhibits a short-wavelength absorption onset at 210 nm. Functional groups present in the sample were identified by Fourier transform infrared spectrum.
Link to Success: How Blogs Build an Audience by Promoting Rivals
Authors: Mayzlin Dina , Yoganarasimhan Hema 
Published: July 2012

Empirically, we find that Web logs (or “blogs”) often link to other blogs in the same category. We present an analytical model that explains why a rational blogger may choose to link to another blog. We allow bloggers to differ along two dimensions: (1) the ability to post news-breaking content, and (2) the ability to find news in other blogs. By linking, a blog signals to the reader that it will be able to direct her to news in other blogs in the future. The downside of a link is that it is a positive signal on the rival's news-breaking ability. We show that linking will be in equilibrium when the heterogeneity on the ability to break news is low relative to the heterogeneity on the ability to find news in other blogs. One implication of the linking mechanism is that blogs that are high on the news-breaking ability are more likely to gain readers. Hence, despite the fact that bloggers link for purely selfish reasons, the macro effects of this activity is that readers' learning is enhanced. This paper was accepted by J. Miguel Villas-Boas, marketing.
Dividend Smoothing and Predictability
Authors: Chen Long , Da Zhi , Priestley Richard 
Published: July 2012

The relative predictability of returns and dividends is a central issue because it forms the paradigm to interpret asset price variation. A little studied question is how dividend smoothing, as a choice of corporate policy, affects predictability. We show that even if dividends are supposed to be predictable without smoothing, dividend smoothing can bury this predictability. Because aggregate dividends are dramatically more smoothed in the postwar period than before, the lack of dividend growth predictability in the postwar period does not necessarily mean that there is no cash flow news in stock price variations; rather, a more plausible interpretation is that dividends are smoothed. Using two alternative measures that are less subject to dividend smoothing—net payout and earnings—we reach the consistent conclusion that cash flow news plays a more important role than discount rate news in price variations in the postwar period. This paper was accepted by Wei Xiong, finance.
Miszelle. ′Inb(w) ḥḏ “White wall(s)”: A Town or White Limestone Cliffs?
Authors: Verner Miroslav 
Published: July 2012

Abstract
The text on a Fifth Dynasty sealing found in the pyramid complex of Raneferef is a rare piece of historical evidence confirming the commonly accepted presumption that Ỉnb in Ptah’s epithet was merely an abbreviated form of ’Inb(w) ḥḏ and, at the same time, suggesting that the enclosure wall of ’Inb(w) ḥḏ was very probably decorated with the “Prunkscheintür”-pattern.
Measurement of fasting salivary insulin and its relationship with serum insulin in children
Authors: Fabre B , Maccallini G , Oneto A , Gonzalez D , Hirschler V , Aranda C , Berg G 
Published: July 2012

BackgroundSaliva is a useful sample as a source of hormones for the diagnosis of different diseases, particularly in pediatric patients and aged individuals, because saliva offers a noninvasive and stress-free alternative to serum collection. The aim of this study was to validate a salivary insulin method and to check its clinical application in pediatric patients.MethodsSaliva samples were collected from 130 boys and 147 girls aged 6–14 years. Salivary and serum insulin levels were measured with the chemiluminescent automated method Access (Beckman Coulter, Brea, CA, USA). Serum blood glucose levels were measured with the glucose oxidase method in an autoanalyzer.ResultsThe precision profile of the method was determined for six aliquots of different concentrations from pools of saliva, and the coefficients of variation (CV) were 2.4% for 1 μUI/ml, 4% for 0.5, 8.9% for 0.25, 19% for 0.12, 28% for 0.06, and 38% for 0.03 μUI/ml, being the functional sensibility (concentration corresponding to a 20% CV) 0.12 μUI/ml. Insulin recovery was 100.13%. Salivary insulin levels diminished 29.8% in samples stored during 7 days at 2–8 °C. Differences in insulin values were not observed when samples were stored at −20 °C during 7 days. The methods used to measure salivary and serum insulin correlated significantly (r=0.92, P<0.001). However, at levels of serum insulin >20 μUI/ml, this correlation declined (r=0.57, P=0.083).ConclusionThe proposed method for salivary insulin measurement showed convenient analytical characteristics.
ENDOCRINOLOGY IN PREGNANCY: Thyroid antibodies and risk of preterm delivery: a meta-analysis of prospective cohort studies
Authors: He Xiaoyan , Wang Pingping , Wang Zengfang , He Xiaoqin , Xu Donghua , Wang Bin 
Published: July 2012

BackgroundObservational studies suggest possible associations between thyroid antibodies and risk of preterm delivery. However, whether thyroid antibodies are risk factors of preterm labor remains controversial. Our goal was to evaluate the associations between thyroid antibodies and risk of preterm delivery by conducting a meta-analysis of prospective cohort studies.MethodsPubMed, Embase, and Wangfang databases were searched through January 2012 to identify studies that met pre-stated inclusion criteria. Data were extracted using standardized forms. Either a fixed- or a random-effects model was used to calculate the overall combined relative ratio (RR) with its corresponding 95% confidence interval (95% CI) to evaluate the relationship between thyroid antibodies and preterm delivery risk. Subgroup analyses were mainly performed by type of thyroid antibodies including thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (TG-Ab).ResultsEleven prospective cohort studies involving 35 467 participants were included. The combined RR of preterm delivery for pregnant women with thyroid antibodies compared with the reference group was 1.41 (95% CI 1.08–1.84, P=0.011). Subgroup analysis yielded the combined RR of preterm delivery for pregnant women with TPO-Ab compared with the reference group was 1.69 (95% CI 1.19–2.41, P=0.003), whereas pregnant women with positive TG-Ab had no obvious risk of preterm delivery compared with the reference group (RR=0.88, 95% CI 0.60–1.29, P=0.513). Sensitivity analysis restricted to studies excluding women with thyroid dysfunction yielded similar results. Meta-regression analysis suggested that the status of exclusion or inclusion of women with thyroid dysfunction was the major source of heterogeneity in this meta-analysis. No evidence of publication bias was observed.ConclusionsCurrent evidence suggests that the presence of TPO-Ab in pregnant women significantly increases the risk of preterm delivery.
THERAPY OF ENDOCRINE DISEASE: A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy
Authors: Han Tingting , Bai Jiefei , Liu Wei , Hu Yaomin 
Published: July 2012

ObjectiveTo evaluate the effects and safety of 300–600 mg α-lipoic acid (ALA) given i.v. for diabetic peripheral neuropathy (DPN).MethodsWe searched the databases of Medline, Embase, and Cochrane central register of Controlled Trials and Chinese biological medicine for clinical trials of ALA in the treatment of DPN. Data were extracted to examine methodological quality and describe characteristics of studies. The primary outcomes were efficacy, median motor nerve conduction velocity (MNCV), median sensory nerve conduction velocity (SNCV), peroneal MNCV, and peroneal SNCV. Secondary outcomes were adverse events.ResultsFifteen randomized controlled trials met the inclusion criteria. The treatment group involved the administration of ALA 300–600 mg i.v. per day. And the control group used the same interventions except for ALA. Compared with the control group, nerve conduction velocities increased significantly in the treatment group. The weighted mean differences in nerve conduction velocities were 4.63 (95% confidence interval 3.58–5.67) for median MNCV, 3.17 (1.75–4.59) for median SNCV, 4.25 (2.78–5.72) for peroneal MNCV, and 3.65 (1.50–5.80) for peroneal SNCV in favor of the treatment group. The odds ratio in terms of efficacy was 4.03 (2.73–5.94) for ALA. Furthermore, no serious adverse events were observed during the treatment period.ConclusionsThe results of this meta-analysis provide evidence that treatment with ALA (300–600 mg/day i.v. for 2–4 weeks) is safe and that the treatment can significantly improve both nerve conduction velocity and positive neuropathic symptoms. However, the evidence may not be strong because most of the studies included in this meta-analysis have poor methodological quality.
DNA Replication Origin Function Is Promoted by H3K4 Di-methylation inSaccharomyces cerevisiae
Authors: Rizzardi Lindsay F , Dorn Elizabeth S , Strahl Brian D , Cook Jeanette Gowen 
Published: July 2012

AbstractDNA replication is a highly regulated process that is initiated from replication origins, but the elements of chromatin structure that contribute to origin activity have not been fully elucidated. To identify histone post-translational modifications important for DNA replication, we initiated a genetic screen to identify interactions between genes encoding chromatin-modifying enzymes and those encoding proteins required for origin function in the budding yeast Saccharomyces cerevisiae. We found that enzymes required for histone H3K4 methylation, both the histone methyltransferase Set1 and the E3 ubiquitin ligase Bre1, are required for robust growth of several hypomorphic replication mutants, including cdc6-1. Consistent with a role for these enzymes in DNA replication, we found that both Set1 and Bre1 are required for efficient minichromosome maintenance. These phenotypes are recapitulated in yeast strains bearing mutations in the histone substrates (H3K4 and H2BK123). Set1 functions as part of the COMPASS complex to mono-, di-, and tri-methylate H3K4. By analyzing strains lacking specific COMPASS complex members or containing H2B mutations that differentially affect H3K4 methylation states, we determined that these replication defects were due to loss of H3K4 di-methylation. Furthermore, histone H3K4 di-methylation is enriched at chromosomal origins. These data suggest that H3K4 di-methylation is necessary and sufficient for normal origin function. We propose that histone H3K4 di-methylation functions in concert with other histone post-translational modifications to support robust genome duplication.
Synthesis, characterization, and dielectric properties of nanocrystalline Ba1−xPbxZrO3(0 ≤x≤ 0.75) by polymeric citrate precursor route
Authors: Al-Hartomy Omar A. , Ubaidullah Mohd , Khatoon Sarvari , Madani Jamal H. , Ahmad Tokeer 
Published: July 2012

Abstract
Comparison of Two-Dimensional and Three-Dimensional Images for Phenotypic Assessment of Craniofacial Microsomia
Authors: Birgfeld Craig B. , Saltzman Babette S. , Luquetti Daniela V. , Latham Kerry , Starr Jackie R. , Heike Carrie L. 
Published: July 2012

Background and Purpose Three-dimensional surface imaging is used in many craniofacial centers. However, few data exist to indicate whether such systems justify their cost. Craniofacial microsomia is associated with wide phenotypic variability and can affect most facial features. The purpose of this study is to compare three-dimensional versus two-dimensional images for classification of facial features in individuals with craniofacial microsomia. Methods We obtained a series of two-dimensional and three-dimensional images of 50 participants, aged 0-20 years, diagnosed with craniofacial microsomia, microtia, or Goldenhar syndrome. Three clinicians classified the craniofacial features on each image, and ratings were compared by calculating kappa statistics. We also evaluated image quality using a 5-point Likert scale. Results Reliability estimates were high for most features using both two-dimensional and three-dimensional image data. Our three-dimensional protocol did not allow for scoring of facial animation, occlusal cant, or tongue anomalies. Image quality scores for the mandible and soft tissue assessment were higher for three-dimensional images. Raters preferred two-dimensional photographs for assessment of the ear, ear canal, and eyes. Conclusions Both three-dimensional and two-dimensional images provide useful data for objective characterization of the craniofacial features affected in craniofacial microsomia. A series of two-dimensional images has relative advantages for assessment of some specific features, such as the ear, though three-dimensional images may have advantages for quantitative analysis and qualitative assessment of deformities of the jaw and soft tissue. These results should apply to any assessment of these features with or without a craniofacial microsomia diagnosis.
Bone Grafting, Corticotomy, and Orthodontics: Treatment of Cleft Alveolus in a Chinese Cohort
Authors: Mao Li-Xia , Shen Guo-Fang , Fang Bing , Xia Yun-Hui , Ma Xu-Hui , Wang Bo 
Published: July 2012

Objective A multimodal therapy was applied to solve a set of related problems including collapse of the posterior segment, high level gingival margin of canine, and resorption of grafted bone in a cohort of Chinese youngsters with cleft lip and palate. This study aimed to evaluate the benefits of this treatment procedure. Methods Thirty patients with unilateral cleft lip and palate were included in this prospective study. All patients had previously undergone only cleft lip and palate repair and presented with alveolar cleft and an obvious step in the gingival margin between the canine tooth and the teeth beside it. A multimodal therapy that included bone grafting, corticotomy, and orthodontics was applied to solve these problems. Grafted bone volume, parallelism of the roots, root resorption, gingival margin, and mobility of the canine on the cleft side were established before surgery, 1 week after surgery, and after straightening of the canine. Results Less than 25% of the grafted bone was reabsorbed in 25 of the 30 patients, while less than 50% was resorbed in the remaining five. The roots of the canines on the cleft side were mostly parallel to the adjacent teeth. Root resorption and mobility of the canines were slight. The difference in the gingival margin between the canines on the cleft side and the other side was small. Conclusions Canines moved into the grafted bone safely and effectively, thus achieving a normal gingival margin and retaining grafted bone volume in one operation.
Auditors' Relationship with Their Accounting Firm and Its Effect on Burnout, Turnover Intention, and Post-Employment Citizenship
Authors: Herda David N. 
Published: July 2012

SUMMARY
This summary discusses two related papers (one focusing on auditors currently employed by their firm and the other on firm alumni) that examine the relationship between auditors and their firm; both papers address auditors' commitment to their firm and how it affects important organizational outcomes including burnout, turnover intention, and post-employment citizenship. Herda and Lavelle's (2012) paper, “The Auditor-Audit Firm Relationship and Its Effect on Burnout and Turnover Intention,” suggests that stronger relationships between auditors and their firms can reduce burnout and turnover intention. Herda and Lavelle's (2011) paper, “The Effects of Organizational Fairness and Commitment on the Extent of Benefits Big Four Alumni Provide Their Former Firm,” investigates how these relationships continue to provide benefits to the firm after the auditor's employment with the firm has ended. The results of both papers underscore the importance of fair treatment in building high-quality relationships between auditors and their firm. If audit firms use fair procedures when making organizational decisions (e.g., performance evaluations, scheduling, paid time-off), then current auditors are less likely to burn out and leave the firm, and former auditors are more likely to send the firm business.
Maternal Efficacy and Safety Outcomes in a Randomized, Controlled Trial Comparing Insulin Detemir With NPH Insulin in 310 Pregnant Women With Type 1 Diabetes
Authors: Mathiesen Elisabeth R. , Hod Moshe , Ivanisevic Marina , Duran Garcia Santiago , Brøndsted Lise , Jovanovič Lois , Damm Peter , McCance David R. ,   on behalf of the Detemir in Pregnancy Study Group
Published: July 2012

OBJECTIVE
This randomized, controlled noninferiority trial aimed to compare the efficacy and safety of insulin detemir (IDet) versus neutral protamine Hagedorn (NPH) (both with prandial insulin aspart) in pregnant women with type 1 diabetes.

RESEARCH DESIGN AND METHODS
Patients were randomized and exposed to IDet or NPH up to 12 months before pregnancy or at 8–12 weeks gestation. The primary analysis aimed to demonstrate noninferiority of IDet to NPH with respect to A1C at 36 gestational weeks (GWs) (margin of 0.4%). The data were analyzed using linear regression, taking several baseline factors and covariates into account.

RESULTS
A total of 310 type 1 diabetic women were randomized and exposed to IDet (n = 152) or NPH (n = 158) up to 12 months before pregnancy (48%) or during pregnancy at 8–12 weeks (52%). The estimated A1C at 36 GWs was 6.27% for IDet and 6.33% for NPH in the full analysis set (FAS). IDet was declared noninferior to NPH (FAS, –0.06% [95% CI –0.21 to 0.08]; per protocol, –0.15% [–0.34 to 0.04]). Fasting plasma glucose (FPG) was significantly lower with IDet versus NPH at both 24 GWs (96.8 vs. 113.8 mg/dL, P = 0.012) and 36 GWs (85.7 vs. 97.4 mg/dL, P = 0.017). Major and minor hypoglycemia rates during pregnancy were similar between groups.

CONCLUSIONS
Treatment with IDet resulted in lower FPG and noninferior A1C in late pregnancy compared with NPH insulin. Rates of hypoglycemia were comparable.
Intervention Costs and Cost-Effectiveness of a Successful Telephonic Intervention to Promote Diabetes Control
Authors: Schechter Clyde B. , Cohen Hillel W. , Shmukler Celia , Walker Elizabeth A. 
Published: July 2012

OBJECTIVE
To characterize the costs and cost-effectiveness of a telephonic behavioral intervention to promote glycemic control in the Improving Diabetes Outcomes study.

RESEARCH DESIGN AND METHODS
Using the provider perspective and a time horizon to the end of the 1-year intervention, we calculate the costs of a telephonic intervention by health educators compared with an active control (print) intervention to improve glycemic control in adults with type 2 diabetes. We calculate the cost-effectiveness ratios for a reduction of one percentage point in hemoglobin A1c (A1C), as well as for one participant to achieve an A1C &lt;7%. Base-case and sensitivity analysis results are presented.

RESULTS
The intervention cost $176.61 per person randomized to the telephone group to achieve a mean 0.36 percentage point of A1C improvement. The incremental cost-effectiveness ratio was $490.58 per incremental percentage point of A1C improvement and $2,617.35 per person over a 1-year intervention in achieving the A1C goal. In probabilistic sensitivity analysis, the median (interquartile range) of per capita cost, cost per percentage point reduction in A1C, and cost per person achieving the A1C goal of &lt;7% are $175.82 (147.32–203.56), $487.75 (356.50–718.32), and $2,312.88 (1,785.58–3,220.78), respectively.

CONCLUSIONS
The costs of a telephonic intervention for diabetes self-management support are moderate and commensurate to the modest associated improvement in glycemic control.
Sectional anatomic and magnetic resonance imaging features of the head of juvenile loggerhead sea turtles (Caretta caretta)
Authors: Arencibia Alberto , Hidalgo María R. , Vázquez José M. , Contreras Samuel , Ramírez Gregorio , Orós Jorge 
Published: July 2012

Abstract
Objective—To compare anatomic features of cross-sectional specimens with those of MRI images of the heads of loggerhead sea turtles (Caretta caretta).
Animals—5 cadavers of juvenile female loggerhead sea turtles.
Procedures—Spin-echo T1-weighted and T2-weighted MRI scans were obtained in sagittal, transverse, and dorsal planes with a 0.2-T magnet and head coil. Head specimens were grossly dissected and photographed. Anatomic features of the MRI images were compared with those of gross anatomic sections of the heads from 4 of these turtles.
Results—In the MRI images, anatomic details of the turtles' heads were identified by the characteristics of signal intensity of various tissues. Relevant anatomic structures were identified and labeled on the MRI images and corresponding anatomic sections.
Conclusions and Clinical Relevance—The MRI images obtained through this study provided valid information on anatomic characteristics of the head in juvenile loggerhead sea turtles and should be useful for guiding clinical evaluation of this anatomic region in this species.