bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interleukin‐22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts
Authors: Kim Kyoung‐Woon , Kim Hae‐Rim , Park Jin‐Young , Park Jin‐Sil , Oh Hye‐Jwa , Woo Yun‐Ju , Park Mi‐Kyung , Cho Mi‐La , Lee Sang‐Heon 
Published: October 2011

AbstractObjectiveTo examine the regulatory role of interleukin‐22 (IL‐22) in the expression of RANKL and induction of osteoclastogenesis in rheumatoid arthritis (RA).MethodsConcentrations of IL‐22 and RANKL in the serum and synovial fluid of RA patients were measured using enzyme‐linked immunosorbent assay. RA synovial fibroblasts were treated with recombinant human IL‐22 (rhIL‐22), and the expression of RANKL messenger RNA (mRNA) and protein was measured using real‐time polymerase chain reaction, Western blotting, and intracellular immunostaining. Human monocytes were cocultured with IL‐22–prestimulated RA synovial fibroblasts and macrophage colony‐stimulating factor, and osteoclastogenesis was assessed by counting the multinucleated cells (those staining positive for tartrate‐resistant acid phosphatase).ResultsThe IL‐22 concentration in the synovial fluid was higher in RA patients than in patients with osteoarthritis (OA). The serum IL‐22 concentration was also higher in RA patients than in OA patients and healthy volunteers, and this correlated with serum titers of rheumatoid factor and anti–cyclic citrullinated peptide antibodies. In RA synovial fibroblasts treated with rhIL‐22, the expression of RANKL mRNA and protein was increased in a dose‐dependent manner. IL‐22–induced RANKL expression was down‐regulated significantly by the inhibition of p38 MAPK/NF‐κB or JAK‐2/STAT‐3 signaling. In human monocytes cocultured with IL‐22–prestimulated RA synovial fibroblasts in the absence of exogenous RANKL, the monocytes differentiated into osteoclasts, but this osteoclastogenesis decreased after p38 MAPK/NF‐κB or JAK‐2/STAT‐3 signaling was inhibited.ConclusionThese results show that IL‐22 up‐regulates RANKL expression in RA synovial fibroblasts and induces osteoclastogenesis. These effects are mediated by the p38 MAPK/NF‐κB and JAK‐2/STAT‐3 signaling pathways.
Taktile und laserbasierte Messverfahren für die messtechnische Überwachung einer Autobahnbrücke
Authors: Liebig Jan Peter , Grünberg Jürgen , Paffenholz Jens‐André , Vennegeerts Harald 
Published: October 2011

AbstractDie zutreffende Abbildung der Einwirkungen auf ein Tragwerk durch geeignete Lastmodelle ist eine wichtige Voraussetzung für dessen Zuverlässigkeit und Dauerhaftigkeit. Bei Brückenbauwerken sind insbesondere die Lastmodelle der Straßenverkehrseinwirkungen einem ständigen Wandel unterlegen. Dies macht den regelmäßigen Abgleich der Lastmodelle auf das aktuelle Verkehrsaufkommen notwendig. Das Verkehrsaufkommen lässt sich durch unterschiedliche Arten von Weigh‐In‐Motion‐Systemen ermitteln und durch numerische Untersuchungen erweiternd beschreiben. Der Schwerpunkt dieses Beitrags liegt in der Darstellung des kombinierten Einsatzes von direkten Messungen am Bauwerk sowie in der Anwendung laserbasierter Messmethoden aus dem Bereich der Ingenieurgeodäsie zur Kalibrierung eines Finite‐Elemente‐Rechenmodells (FE‐Modell), das der numerischen Untersuchung des aktuellen wie auch des prognostizierten Verkehrsaufkommens dient.Mapping of real impacts on a structure by acceptable load models is a fundamental assumption for its reliability and durability. Especially for road bridges traffic load models are affected by increasing traffic loads. This needs a periodical calibration of the load models to the actual traffic volume, which can be achieved by different ways of Weigh‐In‐Motion‐Systems and numerical investigations. The main focus of this article is in the presentation of a combined application of structural measurements and laser based geodetic measurements to calibrate a numerical model. This model allows a numerical investigation of the actual traffic volume and predicted traffic loads.
Experimentelle Untersuchung der Verformungsakkumulation eines Flachgründungsmodells von Offshore‐Windenergieanlagen
Authors: Zachert Hauke , Triantafyllidis Theodoros , Wienbroer Holger 
Published: October 2011

AbstractGründungen von Offshore‐Windenergieanlagen sind im Laufe ihre Nutzungsdauer vielen Millionen von Lastwechseln ausgesetzt. Diese Wechselbeanspruchung kann zu Setzungen und Verdrehungen der Anlage führen, die die Gebrauchstauglichkeit beeinträchtigen. Das Verhalten von Flachgründungen bei solchen Beanspruchungen wurde bisher allerdings nur wenig erforscht. Daher wurden zahlreiche experimentelle Untersuchungen an einem kleinmaßstäblichen Flachfundament unter horizontaler zyklischer Belastung durchgeführt. Die in diesem Beitrag vorgestellten Modellversuche wurden auf einem trockenen Feinsand durchgeführt. Nach einer kurzen allgemeinen Einführung wird das experimentelle Setup vorgestellt. Es besteht aus einer speziell entworfenen Mess‐ und Belastungstechnik sowie einer Einrichtung zur Herstellung von Proben mit mitteldichter bis dichter Lagerung. Anschließend werden die Versuchsergebnisse vorgestellt. Untersucht wurden das Setzungs‐ und Verdrehungsverhalten unter ein‐ und mehrdimensionaler Beanspruchung und unter mehrstufiger Schwelllastbeanspruchung. Des Weiteren wurde das Verhalten nach einem einzelnen Großereignis, wie es beispielsweise eine sogenannte “freak wave“ darstellt, untersucht. Infolge eines darauf folgenden Zyklenpakets wurde der Abbau der aus dem Großereignis resultierenden Verdrehung beobachtet. Die Einflüsse auf diese Rückdrehung wurden systematisch untersucht, wobei sowohl Lastamplituden, ‐mittelwerte und ‐richtungen als auch die Lagerungsdichte des Bodens variiert wurden.Experimental investigations on the deformations accumulation of a shallow foundation model for offshore wind turbines. Foundations of offshore wind turbines are exposed to millions of load cycles during their service life. This cyclic loading can lead to settlements and rotations of the structure, affecting its serviceability. The behaviour of shallow foundations under such loading conditions has been rarely investigated so far. Thus, numerous experimental studies were performed on a small scale foundation model under horizontal cyclic loading. The focus of this contribution is on these model tests which were performed on dry fine sand. After a brief general introduction, the experimental setup is presented. It consists of a specially designed measuring and loading device, as well as a facility for the preparation of medium dense to dense samples. Afterwards the experimental results are presented. The settlement and rotation behaviour under single‐ and multi‐dimensional loading as well as under multistage one‐way loading was investigated. Furthermore, the behaviour after a single large wave event, like a so‐called freak wave, was studied. Due to the subsequent cycle packages a reduction of rotations resulting from the strong event was observed. The influences on this backward rotation were investigated systematically. The effects of different load amplitudes, average loads, load directions and relative densities are discussed.
Design of an X‐Ray Powder Diffraction Probe for Multi‐Channel Application: Proof of Principle
Authors: Fait M. J. G. , Schneider M. , Tilgner J. , Bjeoumikhov A. , Linke D. , Rodemerck U. 
Published: October 2011

AbstractThe design of an X‐ray powder diffraction probe and its integration with a multi‐channel reactor system for potential application in high‐throughput experimentation is presented. The working principle of the apparatus is exemplified by measurements of corundum and of the phase change observed when oxidizing vanadium(III) oxide (V2O3) in air during heating up to 450 °C. The phase transformations of the parent material were monitored by phase identification of the crystalline intermediate vanadium(IV) oxide (VO2) and the final product vanadium(V) oxide (V2O5).
ChemInform Abstract: Syntheses, Structures and Raman Spectra of Cd(BF4)(AF6) (A: Ta, Bi) Compounds.
Authors: Radan Kristian , Lozinsek Matic , Goreshnik Evgeny , Zemva Boris 
Published: October 2011

AbstractThe title compounds are obtained in nearly quantitative yields from anhydrous HF solutions containing either Cd(BF4)2, CdF2, and TaF5, or Cd(BF4)2 and Cd(BiF6)2.
ChemInform Abstract: Aluminum(III) Fluoride Originating from Decomposition of Hydrazinium Fluoroaluminate(III) under Oxidative Conditions: Syntheses, X‐Ray Photoelectron Spectroscopy and Some Catalytic Reactions.
Authors: Skapin Tomaz , Mazej Zoran , Makarowicz Anna , Jesih Adolf , Nickkho‐Amiry Mahmood , Schroeder Sven L. M. , Weiher Norbert , Zemva Boris , Winfield John M. 
Published: October 2011

AbstractAlF3 is prepared by oxidative (F2) decomposition of [N2H6][AlF5] under gas—solid conditions and in the presence of liquid anhydrous HF.
ChemInform Abstract: Two New Methods of Synthesis for the Perbromate Ion: Chemistry and Determination by LC‐MS/MS.
Authors: Pisarenko Aleksey N. , Young Robert , Quinones Oscar , Vanderford Brett J. , Mawhinney Douglas B. 
Published: October 2011

AbstractThe formation of perbromate ions by reactions of hypobromite and bromate ions in an alkaline sodium hypobromite solution is demonstrated by liquid chromatography tandem mass spectrometry.
ChemInform Abstract: Bell‐Like [Ga5] Clusters in Eu3Li5+xGa5‐x (x = 0.15).
Authors: Fedorchuk Anatolii , Prots Yurii , Schnelle Walter , Grin Yuri 
Published: October 2011

AbstractEu3Li5.15Ga4.85 is synthesized from the elements at 900 °C for 2 h followed by annealing at 300 °C for 10 months.
ChemInform Abstract: [Ni(en)3][InSbS4]: A One‐Dimensional Polymeric Indium Thioantimonate with a Polar Structure.
Authors: Feng Mei‐Ling , Li Pei‐Xin , Du Ke‐Zhao , Huang Xiao‐Ying 
Published: October 2011

AbstractThe title compound, the first polar indium thioantimonate, is solvothermally synthesized from a mixture of In, Sb, S, and NiCl2 in en (autoclave, 190 °C, 7 d; 8% yield).
ChemInform Abstract: Catalytic Asymmetric α‐Chlorination of 3‐Acyloxazolidin‐2‐one with a Trinary Catalytic System.
Authors: Hamashima Yoshitaka , Nagi Tatsuya , Shimizu Ryo , Tsuchimoto Teruhisa , Sodeoka Mikiko 
Published: October 2011

AbstractA trinary catalytic system allows asymmetric chlorination of aryl acetic acid derivatives in good yield with up to 89% e.e.
ChemInform Abstract: Insertion of Cyclopropanes Between a Carbonyl Carbon and an α‐Carbon of Carbon Compounds with Cyclopropylmagnesium Carbenoids.
Authors: Satoh Tsuyoshi , Kashiwamura Gaku , Nagamoto Shinobu , Sasaki Yuki , Sugiyama Shimpei 
Published: October 2011

AbstractThe reaction produces α‐cyclopropyl‐substituted ketones and is highly stereospecific with respect to the cyclopropylmagnesium carbenoids.
ChemInform Abstract: Simple and Efficient Method for the Halogenation of Oxygenated Aromatic Compounds.
Authors: Koini Eftychia N. , Avlonitis Nicolaos , Calogeropoulou Theodora 
Published: October 2011

AbstractA novel variant concerning oxychlorination or oxybromination of electron‐rich arenes is developed under conditions A)‐D).
ChemInform Abstract: Well‐Defined NHC—Pd(II)—Im (NHC: N‐Heterocyclic Carbene; Im: 1‐Methylimidazole) Complexes Catalyzed Amination of Aryl Chlorides.
Authors: Zhu Lei , Gao Ting‐Ting , Shao Li‐Xiong 
Published: October 2011

AbstractNew air‐ and moisture stable complexes are synthesized and their application in amination reactions of aryl chlorides is investigated.
ChemInform Abstract: Sugar‐monophosphite Ligands Applied to the Asymmetric Ni‐Catalyzed Trialkylaluminum Addition to Aldehydes.
Authors: Alegre Sabina , Dieguez Montserrat , Pamies Oscar 
Published: October 2011

AbstractA variety of glucose‐derived biarylphosphonate ligands is prepared and applied in the Ni‐catalyzed addition of trialkylaluminum towards aromatic aldehydes (I).
ChemInform Abstract: Zirconyl Chloride: An Efficient, Water‐Tolerant, and Reusable Catalyst for the Synthesis of N‐Methylamides.
Authors: Talukdar Dhrubajyoti , Saikia Lakhinath , Thakur Ashim Jyoti 
Published: October 2011

AbstractMicrowave‐assisted condensation of carboxylic acids with dimethylurea allows the preparation of a broad spectrum of N‐methylamides.
ChemInform Abstract: Palladium‐Catalyzed Sonogashira Cross‐Coupling of Organic Tellurides with Alkynes.
Authors: Kawaguchi Shin‐ichi , Srivastava Puneet , Engman Lars 
Published: October 2011

AbstractOptimized reaction conditions are developed for the coupling of alkyl aryl tellurides or tellurol ester (VII).
ChemInform Abstract: E/Z‐Selective Synthesis of Alkylidene‐3‐oxo‐3H‐isobenzofurans by Reaction of Silyl Enol Ethers with Phthaloyl Dichloride.
Authors: Langer Peter , et al. et al. 
Published: October 2011

AbstractThe reaction of various silyl enol ethers with dichloride (I) proceeds with high (E)‐selectivity to provide the desired unsaturated substructures in low to moderate yields.
ChemInform Abstract: Suzuki—Miyaura Reactions of N‐Protected Tribromopyrazoles. Efficient and Site‐Selective Synthesis of 3,4,5‐Triaryl‐pyrazoles, 3,5‐Diaryl‐4‐bromopyrazoles and 5‐Aryl‐3,4‐dibromopyrazoles.
Authors: Khera Rasheed Ahmad , Ali Asad , Rafique Hummera , Hussain Munawar , Tatar Jovana , Saeed Aamer , Villinger Alexander , Langer Peter 
Published: October 2011

AbstractThe reactions proceed with excellent site‐selectivity.
ChemInform Abstract: Triphenylphosphine‐Promoted C‐Vinylation of 4‐Hydroxyquinolines.
Authors: Mohtat Bita , Nahavandian Semiramis , Azar Zohre Najafi , Djahaniani Hoorieh , Hossaini Zinatossadat 
Published: October 2011

AbstractA simple one‐pot synthesis of functionalized 4‐hydroxyquinoline derivatives is presented which as the advantage of neutral conditions.
ChemInform Abstract: Synthesis of 3‐Arylimidazo[1,2‐a]pyridines by a Catalyst‐Free Cascade Process.
Authors: Wu Zhiqing , Pan Yinyin , Zhou Xiangge 
Published: October 2011

AbstractA simple protocol allows the synthesis of the title compounds through cascade reaction of 2‐aminopyridines with dibromoalkenes or bromoacetylenes, respectively.
ChemInform Abstract: Enantioselective [2 + 2 + 2] Cycloaddition of Ketenes and Carbon Disulfide Catalyzed by N‐Heterocyclic Carbenes.
Authors: Wang Xiao‐Na , Shen Li‐Tao , Ye Song 
Published: October 2011

AbstractA mechanism in which the catalytic reaction is initiated by addition of the N‐heterocyclic carbene to ketenes rather than to carbon disulfide is proposed.
ChemInform Abstract: The Novel 3,4‐Dihydropyrimidin‐2(1H)‐one Urea Derivatives of N‐Aryl Urea: Synthesis, Antiinflamatory, Antibacterial and Antifungal Activity Evaluation.
Authors: Tale Rajesh H. , Rodge Atish H. , Hatnapure Girish D. , Keche Ashish P. 
Published: October 2011

AbstractCompounds (IIg) and (IIh) are found to exhibit promising antiinflammatory activities, whereas compounds (IIa)—(IIf) show promising antimicrobial activity against selected pathogenic bacteria and fungi.
ChemInform Abstract: Direct Synthesis of Highly Fused Perimidines by Copper(I)‐Catalyzed Hydroamination of 2‐Ethynylbenzaldehydes.
Authors: Tokimizu Yusuke , Ohta Yusuke , Chiba Hiroaki , Oishi Shinya , Fujii Nobutaka , Ohno Hiroaki 
Published: October 2011

AbstractThe results show that copper‐catalyzed annulation of alkynylbenzaldehydes (I) with diaminonaphthalene (II) and subsequent palladium‐catalyzed arylation provides a convenient access to highly fused perimidine derivatives (IV).
ChemInform Abstract: Efficient One‐Pot Synthesis of Spiro[indoline‐3,4′‐pyrazolo[3,4‐e][1,4]thiazepine] Dione via Three‐Component Reaction.
Authors: Chen Hui , Shi Daqing 
Published: October 2011

AbstractNovel tetracyclic spirooxindole derivatives are efficiently synthesized using p‐toluenesulfonic acid as catalyst.
ChemInform Abstract: Two New Eujindoles from Eupenicillium javanicum.
Authors: Nakadate Shou , Nozawa Koohei , Yaguchi Takashi 
Published: October 2011

AbstractTwo new indole diterpenes, 8,21‐dehydro‐17‐hydroxyeujindole (I) and 8,21‐dehydro‐17,20‐epoxy‐eujindole (II), are isolated from the extract of E.
ChemInform Abstract: Synthesis of Monofluorinated Isofagomine Analogues and Evaluation as Glycosidase Inhibitors.
Authors: Yang Yi , Zheng Feng , Bols Mikael , Marinescu Lavinia G. , Qing Feng‐Ling 
Published: October 2011

AbstractIsomer (III) is found to be a potent inhibitor against β‐glucosidase.
ChemInform Abstract: Benzoic Acid Allopyranosides and Lignan Glycosides from the Twigs of Keteleeria evelyniana.
Authors: He Wen Jun , Fu Zhao Hui , Han Hong Jin , Yan He , Zeng Guang Zhi , Ji Chang Jiu , Chu Hong Biao , Zhang Yu Mei , Tan Ning Hua 
Published: October 2011

AbstractThree new benzoic acid allopyranosides (I) and four new lignan glycosides (II)—(IV) are isolated along with five known compounds from the twigs of the Chinese conifer mentioned above.
ChemInform Abstract: Penicitrinols F—I, New Citrinin Derivatives from the Marine‐Derived Fungus Penicillium citrinum.
Authors: Chen Li , Liu Wei , Huang Kai , Hu Xiao , Fang Zhe‐Xiang , Wu Jiu‐Lin , Zhang Qi‐Qing 
Published: October 2011

AbstractPenicitrinols I(Ia), H(Ib), G(II), and F(III), are isolated from the title plant along with four known analogues.
ChemInform Abstract: A‐90289 A and B, New Inhibitors of Bacterial Translocase I, Produced by Streptomyces sp. SANK 60405
Authors: Fujita Yoko , Kizuka Masaaki , Funabashi Masanori , Ogawa Yasumasa , Ishikawa Tomio , Nonaka Koichi , Takatsu Toshio 
Published: October 2011

Abstractisolation, structural elucidation and biological activity
ChemInform Abstract: Unexpectedly Convenient and Stereoselective Synthesis of 4α‐Acyloxy‐2‐chloropodophyllotoxins in the Presence of BF3·Et2O.
Authors: Xu Hui , Xiao Xiao , Zhao Xue‐Fei , Guo Yong , Yao Xiao‐Jun 
Published: October 2011

AbstractDue to the bulky C‐1 substituent and in the presence of boron trifluoride etherate, O‐acylation of 2‐chloropodophyllotoxin (I) proceeds stereoselectively with retention of the configuration at C‐9.
ChemInform Abstract: Dinapinones, Novel Inhibitors of Triacylglycerol Synthesis in Mammalian Cells, Produced by Penicillium pinophilum FKI‐3864.
Authors: Ohte Satoshi , Matsuda Daisuke , Uchida Ryuji , Nonaka Kenichi , Masuma Rokuro , Omura Satoshi , Tomoda Hiroshi 
Published: October 2011

AbstractDinapinone A (I) is isolated from the culture broth of title fungus as a mixture of the atropisomers.
ChemInform Abstract: Solution Chemistry Synthesis of Intermetallic Gold—Lithium Nanoparticles.
Authors: Bondi James F. , Schaak Raymond E. 
Published: October 2011

AbstractColloidal Au3Li nanoparticles are prepared by reacting Au nanoparticles (obtained by reduction of HAuCl4 with oleylamine; diphenyl ether, ultrasound, 30 min) with a solution of BuLi in diphenyl ether (reflux, 75 min).
Comparison of the adsorption of thin zirconium and titanium oxides films on the 6H‐SiC(0001) surface
Authors: Idczak K. , Skiścim M. , Markowski L. 
Published: October 2011

AbstractIn this work, adsorption of Ti and Zr on the 6H‐SiC(0001) surface under the oxygen pressure of about 5×10−6 Pa was studied. The topography, the chemical composition and the thermal stability were investigated using the X‐ray photoelectron spectroscopy (XPS) and scanning tunneling microscopy (STM). The results show that deposition of titanium oxide onto the SiC surface results in island growth (Volmer–Weber type), which was clearly seen on STM images, whereas Zr oxides adsorb, rather uniformly, in an almost layer‐by‐layer mode. XPS study shows that titanium occurs in different oxidation states, while in case of Zr metallic and dioxide components dominate. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Experimental and Theoretical Studies of the Potential Interconversion of the Amine–Borane iPr2NH·BH(C6F5)2 and the Aminoborane iPr2N=B(C6F5)2 Involving Hydrogen Loss and Uptake
Authors: Robertson Alasdair P. M. , Whittell George R. , Staubitz Anne , Lee Kajin , Lough Alan J. , Manners Ian 
Published: October 2011

AbstractThe amine–borane adduct iPr2NH·BH(C6F5)2 (1) and the aminoborane iPr2N=B(C6F5)2 (2) have been prepared and crystallographically characterised. Interconversion between the two compounds has been attempted using thermal and transition‐metal‐catalysed dehydrogenation and hydrogenation protocols and the overall reaction thermodynamics were probed by computational methods. Thermal dehydrogenation of 1 was found to yield 2, together with uncharacterised by‐products. Treatment of 1 with the carbene 1,3‐di‐tert‐butyl‐4,5‐dihydroimidazol‐2‐ylidene (3) under ambient conditions did not lead to the elimination of hydrogen, but instead to the loss of C6F5H to afford iPr2N=B(H)C6F5 (4). Attempts to hydrogenate aminoborane 2 were unsuccessful with no reaction observed either thermally or in the presence of transition‐metal catalysts. A computational study of the interconversion between compounds 1 and 2 indicated a thermodynamically unfavourable hydrogenation reaction, which was inverse to that demonstrated for the analogous phosphane–borane/phosphanylborane pair, iPr2PH·BH(C6F5)2 (5) and iPr2P–B(C6F5)2 (6). The contrasting reactivity was attributed to the different N–B and P–B π‐bond strengths in 2 and 6, respectively.
Experimental Characterization and Numerical Modeling of PEMFC Stacks Designed for Different Application Fields
Authors: Jannelli E. , Minutillo M. , Perna A. 
Published: October 2011

AbstractProton exchange membrane fuel cell (PEMFC) is regarded as a potential future power technology for stationary and mobile applications due to its high efficiency (full and partial load), rapid start‐up, high power density, and low emissions.Depending on their particular application field (decentralized combined heat and power production, uninterrupted power supplies (UPS), or mobile applications) different operating conditions and designing parameters are required and different performance can be expected.Thus, the aim of this paper is to investigate the behavior and performance of two stacks of the same size, developed with a different approach according to their application sectors.The first PEMFC stack is designed for UPS units or mobile purpose, the second one, is designed to supply heat and power in residential applications (CHP units).The analysis of the stacks behavior has been carried out by using both experimental and numerical investigations.Experimental results have allowed: (i) to characterize the stacks; (ii) to calibrate the numerical model; (iii) to supply useful data for setting and improving the control system.