bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genotypes of NK Cell KIR Receptors, Their Ligands, and Fcγ Receptors in the Response of Neuroblastoma Patients to Hu14.18-IL2 Immunotherapy
Authors: Delgado David C. , Hank Jacquelyn A. , Kolesar Jill , Lorentzen David , Gan Jacek , Seo Songwon , Kim KyungMann , Shusterman Suzanne , Gillies Stephen D. , Reisfeld Ralph A. , Yang Richard , Gadbaw Brian , DeSantes Kenneth B. , London Wendy B. , Seeger Robert C. , Maris John M. , Sondel Paul M. 
Published: October 2010

Abstract
Response to immunocytokine (IC) therapy is dependent on natural killer cells in murine neuroblastoma (NBL) models. Furthermore, killer immunoglobulin-like receptor (KIR)/KIR-ligand mismatch is associated with improved outcome to autologous stem cell transplant for NBL. Additionally, clinical antitumor response to monoclonal antibodies has been associated with specific polymorphic-FcγR alleles. Relapsed/refractory NBL patients received the hu14.18-IL2 IC (humanized anti-GD2 monoclonal antibody linked to human IL2) in a Children's Oncology Group phase II trial. In this report, these patients were genotyped for KIR, HLA, and FcR alleles to determine whether KIR receptor–ligand mismatch or specific FcγR alleles were associated with antitumor response. DNA samples were available for 38 of 39 patients enrolled: 24 were found to have autologous KIR/KIR-ligand mismatch; 14 were matched. Of the 24 mismatched patients, 7 experienced either complete response or improvement of their disease after IC therapy. There was no response or comparable improvement of disease in patients who were matched. Thus KIR/KIR-ligand mismatch was associated with response/improvement to IC (P = 0.03). There was a trend toward patients with the FcγR2A 131-H/H genotype showing a higher response rate than other FcγR2A genotypes (P = 0.06). These analyses indicate that response or improvement of relapsed/refractory NBL patients after IC treatment is associated with autologous KIR/KIR-ligand mismatch, consistent with a role for natural killer cells in this clinical response. Cancer Res; 70(23); 9554–61. ©2010 AACR.
Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics, and Effect on the Insulin-like Growth Factor Axis
Authors: Brown Victoria A. , Patel Ketan R. , Viskaduraki Maria , Crowell James A. , Perloff Marjorie , Booth Tristan D. , Vasilinin Grygoriy , Sen Ananda , Schinas Anna Maria , Piccirilli Gianfranca , Brown Karen , Steward William P. , Gescher Andreas J. , Brenner Dean E. 
Published: October 2010

Abstract
Resveratrol, a naturally occurring polyphenol, has cancer chemopreventive properties in preclinical models. It has been shown to downregulate the levels of insulin-like growth factor-1 (IGF-I) in rodents. The purpose of the study was to assess its safety, pharmacokinetics, and effects on circulating levels of IGF-I and IGF-binding protein-3 (IGFBP-3) after repeated dosing. Forty healthy volunteers ingested resveratrol at 0.5, 1.0, 2.5, or 5.0 g daily for 29 days. Levels of resveratrol and its metabolites were measured by high performance liquid chromatography-UV in plasma obtained before and up to 24 hours after a dose between days 21 and 28. IGF-I and IGFBP-3 were measured by ELISA in plasma taken predosing and on day 29. Resveratrol was safe, but the 2.5 and 5 g doses caused mild to moderate gastrointestinal symptoms. Resveratrol-3-O-sulfate, resveratrol-4′-O-glucuronide, and resveratrol-3-O-glucuronide were major plasma metabolites. Maximal plasma levels and areas under the concentration versus time curve for the metabolites dramatically exceeded those for resveratrol, in the case of areas under the concentration versus time curve, by up to 20.3-fold. Compared with predosing values, the ingestion of resveratrol caused a decrease in circulating IGF-I and IGFBP-3 (P &lt; 0.04 for both), respectively, in all volunteers. The decrease was most marked at the 2.5 g dose level. The results suggest that repeated administration of high doses of resveratrol generates micromolar concentrations of parent and much higher levels of glucuronide and sulfate conjugates in the plasma. The observed decrease in circulating IGF-I and IGFBP-3 might contribute to cancer chemopreventive activity. Cancer Res; 70(22); 9003–11. ©2010 AACR.
Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
Authors: Payton Marc , Bush Tammy L. , Chung Grace , Ziegler Beth , Eden Patrick , McElroy Patricia , Ross Sandra , Cee Victor J. , Deak Holly L. , Hodous Brian L. , Nguyen Hanh Nho , Olivieri Philip R. , Romero Karina , Schenkel Laurie B. , Bak Annette , Stanton Mary , Dussault Isabelle , Patel Vinod F. , Geuns-Meyer Stephanie , Radinsky Robert , Kendall Richard L. 
Published: October 2010

Abstract
In mammalian cells, the aurora kinases (aurora-A, -B, and -C) play essential roles in regulating cell division. The expression of aurora-A and -B is elevated in a variety of human cancers and is associated with high proliferation rates and poor prognosis, making them attractive targets for anticancer therapy. AMG 900 is an orally bioavailable, potent, and highly selective pan-aurora kinase inhibitor that is active in taxane-resistant tumor cell lines. In tumor cells, AMG 900 inhibited autophosphorylation of aurora-A and -B as well as phosphorylation of histone H3 on Ser10, a proximal substrate of aurora-B. The predominant cellular response of tumor cells to AMG 900 treatment was aborted cell division without a prolonged mitotic arrest, which ultimately resulted in cell death. AMG 900 inhibited the proliferation of 26 tumor cell lines, including cell lines resistant to the antimitotic drug paclitaxel and to other aurora kinase inhibitors (AZD1152, MK-0457, and PHA-739358), at low nanomolar concentrations. Furthermore, AMG 900 was active in an AZD1152-resistant HCT116 variant cell line that harbors an aurora-B mutation (W221L). Oral administration of AMG 900 blocked the phosphorylation of histone H3 in a dose-dependent manner and significantly inhibited the growth of HCT116 tumor xenografts. Importantly, AMG 900 was broadly active in multiple xenograft models, including 3 multidrug-resistant xenograft models, representing 5 tumor types. AMG 900 has entered clinical evaluation in adult patients with advanced cancers and has the potential to treat tumors refractory to anticancer drugs such as the taxanes. Cancer Res; 70(23); 9846–54. ©2010 AACR.
Differential Gene Expression in Benign Prostate Epithelium of Men with and without Prostate Cancer: Evidence for a Prostate Cancer Field Effect
Authors: Risk Michael C. , Knudsen Beatrice S. , Coleman Ilsa , Dumpit Ruth F. , Kristal Alan R. , LeMeur Nolwenn , Gentleman Robert C. , True Lawrence D. , Nelson Peter S. , Lin Daniel W. 
Published: October 2010

Abstract
Background: Several malignancies are known to exhibit a “field effect,” whereby regions beyond tumor boundaries harbor histologic or molecular changes that are associated with cancer. We sought to determine if histologically benign prostate epithelium collected from men with prostate cancer exhibits features indicative of premalignancy or field effect.
Experimental Design: Prostate needle biopsies from 15 men with high-grade (Gleason 8-10) prostate cancer and 15 age- and body mass index–matched controls were identified from a biospecimen repository. Benign epithelia from each patient were isolated by laser capture microdissection. RNA was isolated, amplified, and used for microarray hybridization. Quantitative PCR was used to determine the expression of specific genes of interest. Alterations in protein expression were analyzed through immunohistochemistry.
Results: Overall patterns of gene expression in microdissected benign prostate-associated benign epithelium (BABE) and cancer-associated benign epithelium (CABE) were similar. Two genes previously associated with prostate cancer, PSMA and SSTR1, were significantly upregulated in the CABE group (false discovery rate &lt;1%). Expression of other prostate cancer–associated genes, including ERG, HOXC4, HOXC5, and MME, were also increased in CABE by quantitative reverse transcription-PCR, although other genes commonly altered in prostate cancer were not different between the BABE and CABE samples. The expression of MME and PSMA proteins on immunohistochemistry coincided with their mRNA alterations.
Conclusion: Gene expression profiles between benign epithelia of patients with and without prostate cancer are very similar. However, these tissues exhibit differences in the expression levels of several genes previously associated with prostate cancer development or progression. These differences may comprise a field effect and represent early events in carcinogenesis. Clin Cancer Res; 16(22); 5414–23. ©2010 AACR.
Germline Polymorphisms in Genes Involved in the IGF1 Pathway Predict Efficacy of Cetuximab in Wild-typeKRASmCRC Patients
Authors: Winder Thomas , Zhang Wu , Yang Dongyun , Ning Yan , Bohanes Pierre , Gerger Armin , Wilson Peter M. , Pohl Alexandra , Mauro David J. , Langer Christiane , Rowinsky Eric K. , Lenz Heinz-Josef 
Published: October 2010

AbstractPurpose: The insulin-like growth factor 1 (IGF1) signaling pathway is an important growth-regulatory pathway, which plays a crucial role in colorectal cancer (CRC) proliferation, differentiation, migration, angiogenesis, and apoptosis. Previous studies showed that hyperactivation of the IGF1 receptor (IGF1R) may result in resistance to anti–epidermal growth factor receptor–targeted treatment. We tested whether germline variations within the IGF1 pathway are associated with clinical outcome in wild-type (wt) KRAS drug-refractory metastatic CRC (mCRC) patients who were treated with cetuximab monotherapy (IMC-0144).Experimental Design: Formalin-fixed, paraffin-embedded (FFPE) tissue samples of 130 drug-refractory mCRC patients enrolled in IMC-0144, a phase II clinical trial of cetuximab monotherapy, were analyzed. gDNA was extracted from dissected FFPE tumor tissue, and KRAS mutation status and six potentially functional IGF1 and IGF1R polymorphisms were analyzed using direct DNA sequencing or PCR-RFLP. Tumor response analysis was based on recursive partitioning, and survival analyses were based on univariate and multivariate hazard regression models.Results: In univariate and multivariate analyses, five IGF pathway single-nucleotide polymorphisms were significantly associated with progression-free survival (PFS) and/or overall survival (OS). In multivariate combined risk allele analysis, the additive model for PFS and OS was significantly associated with the number of risk alleles in wt KRAS patients (P = 0.001 and P = 0.02, respectively). In addition, wt KRAS patients harboring IGF1 rs2946834 A/A genotype had a 50% objective response rate compared with 0% for A/G genotype.Conclusions: These results indicate that IGF1 pathway polymorphisms are potential predictive/prognostic molecular markers for cetuximab efficacy in wt KRAS mCRC patients. Prospective biomarker-embedded clinical trials are warranted to validate our findings. Clin Cancer Res; 16(22); 5591–602. ©2010 AACR.
Proanthocyanidins Inhibit Photocarcinogenesis through Enhancement of DNA Repair and Xeroderma Pigmentosum Group A–Dependent Mechanism
Authors: Vaid Mudit , Sharma Som D. , Katiyar Santosh K. 
Published: October 2010

AbstractDietary grape seed proanthocyanidins (GSP) inhibit photocarcinogenesis in mice; however, the molecular mechanisms underlying this effect have not been fully elucidated. As ultraviolet B (UVB)-induced DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) has been implicated in skin cancer risk, we studied whether dietary GSPs enhance repair of UVB-induced DNA damage and, if so, what is the potential mechanism? Supplementation of GSPs (0.5%, w/w) with AIN76A control diet significantly reduced the levels of CPD+ cells in UVB-exposed mouse skin; however, GSPs did not significantly reduce UVB-induced CPD+ cells in the skin of interleukin-12p40 (IL-12) knockout (KO) mice, suggesting that IL-12 is required for the repair of CPDs by GSPs. Using IL-12 KO mice and their wild-type counterparts and standard photocarcinogenesis protocol, we found that supplementation of control diet with GSPs (0.5%, w/w) significantly reduced UVB-induced skin tumor development in wild-type mice, which was associated with the elevated mRNA levels of nucleotide excision repair genes, such as XPA, XPC, DDB2, and RPA1; however, this effect of GSPs was less pronounced in IL-12 KO mice. Cytostaining analysis revealed that GSPs repaired UV-induced CPD+ cells in xeroderma pigmentosum complementation group A (XPA)-proficient fibroblasts from a healthy individual but did not repair in XPA-deficient fibroblasts from XPA patients. Furthermore, GSPs enhance nuclear translocation of XPA and enhanced its interactions with other DNA repair protein ERCC1. Together, our findings reveal that prevention of photocarcinogenesis by GSPs is mediated through enhanced DNA repair in epidermal cells by IL-12- and XPA-dependent mechanisms.Cancer Prev Res; 3(12); 1621–9. ©2010 AACR.
Wang Guowei and the Establishment of Chinese Drama in the Modern Canon of Classical Literature
Authors: Llamas Regina 
Published: October 2010

AbstractThis essay examines the process by which Wang Guowei placed Chinese dramatic history into the modern Chinese literary canon. It explores how Wang formed his ideas on literature, drawing on Western aesthetics to explain, through the notions of leisure and play, the impetus for art creation, and on the Chinese notions of the genesis of literature to explain the psychology of literary creation. In order to establish the literary value of Chinese drama, Wang applied these ideas to the first playwrights of the Yuan dynasty, arguing that theirs was a literature created under the right aesthetic and creative circumstances, and that it embodied the value of "naturalness" which he considered a universal standard for good literature. By producing a scholarly critical history of the origins and nature of Chinese drama, Wang placed drama on a par with other literary genres of past dynasties, thus giving it a renewed status and creating at the same time a new discipline of research. Drama had now become an established literary genre.
Trying Again and Again: Multiple Repetitions in Early Modern Reports of Experiments on Snake Bites
Authors: Schickore Jutta 
Published: October 2010

AbstractThis essay deals with a conspicuous feature of early modern experimental reports: references to multiple repetitions. I examine an episode from the history of research on venomous snakes, the dispute between Francesco Redi and Moyse Charas about the cause of death from viper bites. I identify different kinds of repetitions that are described and specify the various different roles that are attributed to repetitions in experimental reports. I argue that repetition (the successive reproduction of one's own experimental trials) should be distinguished from replication (reproducing other investigators' experiments). At first, replications played hardly any role in the exchange, but references to repetitions were crucial to show that contingencies had been obviated, to support inductive generalizations, and to specify the exact cause of an experimental effect. Notably, it appears that the replication of effects by different experimental means was not part of the repository of methodological notions that Redi and Charas brought to bear on their experiments. Reruns and repetitions with variations (including complementary trials) bore the epistemic weight.
Magnetism and Bradwardine's Rule of Motion in Fourteenth- and Fifteenth-Century Treatises
Authors: Rommevaux Sabine 
Published: October 2010

AbstractIn his Tractatus de proportionibus, Thomas Bradwardine describes some devices consisting of a magnet and pieces of iron, in order to put his rule of motion to the test. These devices, or similar ones, are also found in the Questiones super libros Physicorum of Nicole Oresme, and in three works by Blasius of Parma, namely the Questiones de ponderibus, the Questiones super libros Physicorum and the Questiones circa Tractatum proportionum. In this paper, I describe these devices, while examining the theory of magnetism that is in use and I analyse how the arguments on magnets demarcate the field of application of the rule of motion.
A Science of Signs. Aristotelian Meteorology in Reformation Germany
Authors: Vermij Rienk 
Published: October 2010

AbstractLuther, directly opposing the naturalism of Aristotelian natural philosophy, held that unusual events were often worked directly by either God or the devil, not by natural forces. His ideas were taken up and defended in a more philosophical way by authors like Joachim Camerarius and Caspar Peucer. At the university of Wittenberg, they deeply influenced the teaching of natural philosophy. The field most affected was meteorology (traditionally the explanation of Aristotle's Meteorologia), which obtained a prominent place. Meteorological text-books emphasised the final causes of the phenomena they described; not just their place in the general economy of nature, but also their function in warning and punishing sinners. Moreover, they emphasised that many phenomena people had observed were overstepping their natural limits and as such could not be explained naturally. The text-books, however, did not fully break away from the tradition of commentaries to Aristotle's Meteorologia, which emphasised naturalism. Only topics not discussed in this tradition were unambiguously explained as miraculous.
A Review of Terence E. Fretheim's God and World in the Old Testament: A Relational Theology of Creation
Authors: Stallman Robert 
Published: October 2010

AbstractTerence Fretheim's God and World in the Old Testament is a significant contribution to an emerging conversation about the role of creation in biblical theology. This review essay summarizes the nature and scope of Fretheim's work on this topic within the Old Testament. It then offers a positive assessment of Fretheim's care to relate creational and redemptive strands of theological reflection as well as his sensitivity to exegetical and literary features of the texts he has chosen to consider. The essay concludes with three issues I regard as essential for continuing reflection and exploration.
'A Relational Theology that Isn't Relational Enough': A Response to God and World in the Old Testament
Authors: Ellington Scott 
Published: October 2010

AbstractFretheim explores the biblical theme of creation through the lenses of the divine-human relationship. God leaves space for human co-creation, though sometimes at the expense of God's own participation. In considering how best to balance human and divine participation in creation, I consider three areas; the role of the spirit of God in creation, the role of Torah as an expression of relationship with both God and neighbor, and the problem of God in the book of Job.
God—Creation's Hope, Creation—God's Home: A Pentecostal Theological Response to Terence E. Fretheim's God and World in the Old Testament: A Relational Theology of Creation
Authors: Archer Kenneth 
Published: October 2010

AbstractThis essay is a theological response to Terence E. Fretheim's God and World in the Old Testament. I will look first at Fretheim's theological method and hermeneutics. Then, I will examine the theme of God's relationality as it relates to God's openness and human ongoing participation with continuous creation. In this section I will also address praise, judgment, and salvation. Finally, I will offer a brief theological reflection on Pentecostal glossolalic speech as indicated by Rom. 8.26-27. I argue that glossolalic speech as an act of prayerful praise causes one to enter into the deep symbiotic relationship with the sociality of God and nonhuman creation. This is one significant way for the charismatic community to participate with God in continuous creation.
Pentecost Communal Economics and the Household of God
Authors: Augustine Daniela 
Published: October 2010

AbstractModern economic history has been dominated by the neo-classical economic model which has produced contemporary 'market society' with its all permeating commodifying logic. Contrary to the traditional capitalist priority of economic self-interest, Christian spirituality of social transformation upholds the necessity of covenantal civil society that prioritizes the wellbeing of the other as an indispensable part of a just global future.In view of that, the present work offers an exploration of the theological foundations of the Pentecost model of communal ecological economics and its underlying spirituality as following the pattern of God's generous redemptive self-sharing with humanity and the rest of creation. It further examines the relationship between Pentecost, sanctification and moral economic responsibility, and explores the function of the Eucharist in the faith community as a pedagogy of disciplining desires and teaching reverent consumption.
Between This and That: Reality and Sacramentality in the Pentecostal Worldview
Authors: Vondey Wolfgang , Green Chris 
Published: October 2010

AbstractThe Pentecostal worldview is often seen in conflict with a sacramental worldview. In contrast, the authors of this article argue that sacramentality and reality are helpful terms that together illuminate the Pentecostal understanding of being-in-the-world. The essay delineates the challenges and opportunities in bringing both notions into dialogue and suggests that sacramentality is not an optional but a necessary component for a fuller understanding of Pentecostalism. The narrative underlying this proposal follows the tension between a 'this-is-that' and a 'this-is-not-that' hermeneutic characteristic of early modern-day Pentecostals. Central to such an endeavor is an understanding of how the dialogue between Pentecostal and sacramental theology informs and challenges both sides.
The Missions Theology Of Early Pentecost: Call, Challenge, and Opportunity
Authors: Kowalski Rosemarie Daher 
Published: October 2010

AbstractThis article explores three historical components of Pentecostal theology that influenced Pentecostal missionary women by examining missions after the Pentecostal revival of the early twentieth century. This article presents four case studies of such Pentecostals and their responses to Pentecostal experiences and missionary careers for ongoing theological consideration about what it means to 'Go into all the world' as a Pentecostal. According to this study, the Pentecostal experience and reliance on the Holy Spirit was a significant part of Pentecostal women's call to and empowerment for missions, in facing the challenges of missionary service with Pentecostal eschatology, and in following the biblical mandate and narrative to serve in the power of the Spirit with gospel proclamation and accompanying 'signs and wonders'.
J. H. King and 'the Essential Christ': An Historical Investigation
Authors: Moon Tony 
Published: October 2010

AbstractJ.H. King's From Passover to Pentecost 'essential Christ'/'historic Christ' terminological distinction was probably derived from literature produced and conversation generated by the late nineteenth-century American Congregationalist 'future probation' controversy. An examination of the use of this language in that debate confirms that King's From Passover to Pentecost 'essential Christ'/'historic Christ' paragraph is simply an expression of hope for the salvific status and afterlife fate of at least some of the unevangelized, and in continuity with the rest of his writings, is not a positive, optimistic assessment of the value of non-Christian religions.