bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the effects of dexamethasone on pulmonary surfactant lipids based on lipidomics studies
Authors: Wang Zhao , Li Tao , Lin Lili , Xiong Yingcai , Chen Hui , Ye Jin , Ji Jianjian , Wang Shouchuan 
Published: June 2024

AbstractDexamethasone, a glucocorticoid commonly used in pediatric patients, has potent anti‐inflammatory and immunosuppressive properties. However, it is associated with side effects such as reduced lung function and decreased immunity. Pulmonary surfactant lipids are closely linked to lung disease and play a role in reducing surface tension, immune response and antiviral activity. The dysregulation of lipid metabolism is closely associated with lung disease. Hence, untargeted lipidomics may be instrumental in elucidating the effects of dexamethasone on pulmonary surfactant lipids. We obtained surfactant lipid samples from the bronchoalveolar lavage fluid of young mice injected subcutaneously with dexamethasone and conducted a comprehensive lipidomic analysis, comparing them with a control group. We observed a decrease in lipids, such as phosphatidylcholine, phosphatidylglycerol and phosphatidylethanolamine, and an increase in ceramide, fatty acid, diacylglycerol and monoglyceride, which may impact lung health. This study revealed the influence of dexamethasone on pulmonary surfactant lipids, offering new insights into adverse reactions in clinical settings.
Development of an organic polymer monolith column for the nano liquid chromatography fast analysis of monoclonal antibody in infusion bags prepared in a hospital pharmacy
Authors: Andre Claire , Guillaume Yves Claude 
Published: June 2024

AbstractPoly(butyl methacrylate‐co‐ethylene dimethacrylate) monolith was in situ prepared in a liquid chromatography capillary column with a 75 μm internal diameter. This monolith offered high permeability (5.3 ± 10−14 m2) and good peak capacity (140 for a 15 cm column length at 300 nl/min with a 20 min gradient time). This is exemplified by its separation ability in reversed mode for subunit analysis of monoclonal antibodies after IdeS digestion (middle‐up analysis). The potential of this column was also illustrated for the fast analytical control of therapeutic monoclonal antibodies in standardized infusion bags prepared in advance in a pharmacy department. Linearity analysis revealed the column's capability for accurate quantification analysis of the different dose bandings (in mg) of monoclonal antibodies in <2 min. In addition, lifetime analysis data indicated that the column can be highly reproducible and has a long lifetime with stable and low back pressure. The variations observed on the peak shape and area between unstressed (intact) and stressed monoclonal antibodies indicated that our nano liquid chromatographic method was stability indicating. In addition, using a gradient elution mode, the presence of minor components in the infusion bags was visualized.
Extra Virgin Olive Oil′s Main Components′ Antioxidant Activity and in Silico Effect on AKT1
Authors: Boucheffa Saliha , Kheyar‐Kraouche Naouel , Djermouni Meriem , Bettihi Sarra , Sellal Abdelhakim , Cheraft Nassima , Berboucha Meriem , Rovellini Pierangela , Kelebek Hasim , Tamendjari Abderezak 
Published: June 2024

AbstractThe study compared the chemical composition of various olive oils from the northern Algerian province of Bejaia. The research focused on the antioxidant activities of the oil‘s main constituents and their ability to inhibit the AKT1 protein, which is implicated in the development of colorectal cancer. The findings revealed that all of the examined oils fell within the extra virgin olive oil (EVOO) category and exhibited a high oleic acid content, particularly for samples from wild olives. These oils include high amount of ligstroside and oleocanthal, two important phenolic compounds. Wild olive oils stand out from cultivated ones due to their higher bitterness index. In addition, these oils have the highest concentrations of α‐tocopherols and the best oxidative stability. Olive oil extracts demonstrated their antioxidant properties by neutralizing DPPH and ABTS radicals and converting ferric ions (Fe3+) to ferrous ions (Fe2+) for FRAP assay. Molecular docking was applied to assess the interaction between the main compounds identified in the analyzed olive oils and the human AKT1 protein, which is involved in the genesis of colorectal cancer. The findings revealed that lutein, oleuropein aglycone, and ligstroside aglycone had the highest binding affinity for the AKT1 protein. The present study could provide the theoretical foundation for further research on the interaction between AKT1 protein and EVOO compounds.
Eligibility to COAPT trial in the daily practice: A real‐world experience
Authors: Zancanaro Edoardo , Buzzatti Nicola , Denti Paolo , Guicciardi Nicolò Azzola , Melillo Enrico , Monaco Fabrizio , Agricola Eustachio , Ancona Francesco , Alfieri Ottavio , De Bonis Michele , Maisano Francesco 
Published: June 2024

AbstractBackgroundThe COAPT Trial was the first ever to demonstrate a survival benefit in treating functional mitral regurgitation (FMR). That was achieved through transcatheter mitral repair in selected patients. The exact proportion of patients fulfilling COAPT selection criteria in the real‐world is unknown.AimsTo assess the applicability of COAPT criteria in real world and its impact on patients’ survival.MethodsWe assessed the clinical data and follow‐up results of all consecutive patients admitted for FMR at our Department between January 2016 and May 2021 according to COAPT eligibility. COAPT eligibility was retrospectively assessed by a cardiac surgeon and a cardiologist.ResultsAmong 394 patients, 56 (14%) were COAPT eligible. The most frequent reasons for exclusion were MR ≤ 2 (22%), LVEF < 20% or >50% (19%), and non‐optimized GDMT (21.3%).Among Non‐COAPT patients, weighted 4‐year survival was higher in patients who received MitraClip compared to those who were left in optimized medical therapy (91.5% confidence interval [CI: 0.864, 0.96] vs. 71.8% [CI: 0.509, 0.926], respectively, p = 0.027).ConclusionsOnly a minority (14%) of real‐world patients with FMR referred to a tertiary hospital fulfilled the COAPT selection criteria. Among Non‐COAPT patients, weighted 4‐year survival was higher in patients who received MitraClip compared to those who were left in optimized medical therapy (91.5% [0.864, 0.96] vs. 71.8% [0.509, 0.926], respectively, p = 0.027).
Synthesis of Sulfilimines via Visible‐Light‐Mediated Triplet Energy Transfer to Sulfonyl Azides
Authors: Arichi Norihito , Amano Tsuyoshi , Wu Shuhan , Inuki Shinsuke , Ohno Hiroaki 
Published: June 2024

AbstractSulfilimines and their derivatives have garnered considerable interest in both synthetic and medicinal chemistry. Photochemical nitrene transfer to sulfides is known as a conventional synthetic approach to sulfilimines. However, the existing methods have a limited substrate scope stemming from the incompatibility of singlet nitrene intermediates with nucleophilic functional groups. Herein, we report the synthesis of N‐sulfonyl sulfilimines via visible‐light‐mediated energy transfer to sulfonyl azides, uncovering the previously overlooked reactivity of triplet nitrenes with sulfides. This reaction features broad functional group tolerance, water compatibility, and amenability to the late‐stage functionalization of drugs. Thus, this work represents an important example of energy transfer chemistry that overcomes challenges in traditional synthetic methods.
Aspekte der Energiewende. Teil 2: Wie kann der zukünftige heimische Bedarf an PTX‐Produkten gedeckt werden und was werden sie kosten?
Authors: Machhammer Otto , Janisch Ingo 
Published: June 2024

ZusammenfassungAufbauend auf den Kosten zur Herstellung von PTX‐Produkten wird ein einfaches Rechenmodell zur Ermittlung der Kosten für deren Schiffstransport und Reformierung zu Wasserstoff vorgestellt. Die für die PTX‐Produktion erforderliche Energie wird ausschließlich von Windparks bereitgestellt. Exemplarisch werden die Kosten für den Transport der Power‐to‐X (PTX)‐Produkte NH3, MeOH, flüssiger organischer Wasserstoffträger (LOHC) und von Fischer‐Tropsch‐Diesel aus Chile (Haru Oni) und Marokko (Tarfaya) ermittelt. Verglichen werden diese Kosten mit den Kosten der Wasserstoff‐Produktion an drei heimischen Standorten mit sehr guten bis sehr mäßigen Windverhältnissen in der Reihenfolge Dornum (norddeutsche Küste), Senftenberg (Lausitz) und Ludwigshafen (Rheingraben). Daneben wird auch ein Kostenvergleich für Fischer‐Tropsch‐Diesel angestellt und die Flächenbedarfe für die heimische Produktion werden ermittelt.
Numerical investigation on mixing behaviour in the contact zone of an industrial‐scale dissolved air flotation tank
Authors: Chen Xiuzhen , Huang Jingdong , Hao Yubing 
Published: June 2024

AbstractThe mixing behaviour of the wastewater and the recycle bubbly water in the contact zone could affect the separation performance of dissolved air flotation systems. In this study, the mixing characteristics in the contact zone of an industrial‐scale dissolved air flotation tank were investigated using the computational fluid dynamics method. At first, the influence of the turbulence model on the simulation results was clarified. It is demonstrated that the realizable k‐ε model could predict the gas holdup distribution with better accuracy, and the maximum relative deviation between the predicted gas holdup and the experimental results is only 10%. The influence of the geometry and operating parameters on the mixing process was then studied numerically. It is found that the mixing performance in the contact zone could be improved by decreasing the height position of the nozzle inlet in a certain range. The reason is that microbubbles disperse better in the bottom region and a double circulation flow state forms in the contact zone when the nozzle inlet is installed at a low height. Additionally, the mixing process could be further enhanced by decreasing the diameter of the nozzle inlet. As to the operating conditions, increasing the recycle ratio could not only increase the gas holdup but also improve the mixing performance in the contact zone. When the recycle flow rate remains constant, increasing the wastewater flow rate will lead to a decrease in gas holdup and deterioration of the mixing effect.
Inline monitoring of lactobionic acid production from cheese whey by Pseudomonas taetrolens in a stirred bioreactor using electrical conductivity
Authors: Romano Roberta , Alberini Federico , Raddadi Noura , Fava Fabio , Paglianti Alessandro 
Published: June 2024

AbstractIn this study, we introduce a novel experimental approach and present a simplified mathematical model for a quick monitoring of a biotec process producing lactobionic acid (LBA). It relies on monitoring the electrical conductivity of the fermentation broth and it is designed to predict the concentration of LBA throughout the microbial cheese whey valorization via LBA production. Following a systematic series of experiments conducted to refine the mathematical model, we performed conductivity monitoring during LBA production from “caciotta” and “squacquerone” wheys by Pseudomonas taetrolens in a 3 L stirred tank bioreactor. Throughout the bioproduction process, the conductivity values exhibited an upward trend corresponding to the increase in LBA concentration. Our findings underscore the feasibility and advantages of employing inline conductivity monitoring during LBA production from various cheese wheys. The results emphasize that conductivity measurements can effectively estimate product concentration in a fermentation process, particularly when there is a shift in ionic concentration. Furthermore, these conductivity measurements offer valuable insights for monitoring and optimizing the working conditions in a fermentation process.
Cost‐Effectiveness and Budget Impact Analysis of Apixaban and Rivaroxaban Versus Warfarin in the Prevention of Stroke in Patients With Non‐Valvular Atrial Fibrillation (NVAF) in Iran
Authors: Tajik Amirmohammad , Abbasi Azam , Goudarzi Zahra , Izadi‐Moud Azadeh , Varmaghani Mehdi 
Published: June 2024

ABSTRACTIntroductionThis study evaluates the cost‐effectiveness of Apixaban and Rivaroxaban, compared to Warfarin, for stroke prevention in patients with non‐valvular atrial fibrillation in Iran.MethodA Markov model with a 30‐year time horizon was employed to simulate and assess different treatment strategies' cost‐effectiveness. The study population comprised Iranian adults with NVAF, identified through specialist consultations, hospital visits, and archival record reviews. Direct medical costs, direct nonmedical, and indirect costs were included. Quality‐adjusted life years (QALY) were assessed using an EQ‐5D questionnaire. This study utilized a cost‐effectiveness threshold of $11 134 per QALY.ResultsApixaban demonstrated superior cost‐effectiveness compared to Rivaroxaban and Warfarin. Over 30 years, total costs were lower in the Apixaban and Rivaroxaban groups compared to the Warfarin group ($126.18 and $109.99 vs. $150.49). However, Apixaban showed higher total QALYs gained compared to others (0.134 vs. 0.133 and 0.116). The incremental cost‐effectiveness ratio for comparing Apixaban to Warfarin was calculated at −1332.83 cost per QALY, below the threshold of $11 134, indicating Apixaban's cost‐effectiveness. Sensitivity analyses confirmed the robustness of the findings, with ICER consistently remaining below the threshold. Over 5 years (2024−2028) of Apixaban usage, the incremental cost starts at USD 70 250 296 in the first year and gradually rises to USD 71 770 662 in the fifth year. DSA and PSA were assessed to prove the robustness of the results.ConclusionThis study shows that Apixaban is a cost‐effective option for stroke prevention in non‐valvular atrial fibrillation patients in Iran compared to Warfarin.
A review of vortex pinning in REBa2Cu3O7‐x coated conductors
Authors: Wang Tong‐Xin , Huang Da‐Xing , Ding Fa‐Zhu , Dong Hao , Yu Hao , Dun Chao‐Chao , Gu Hong‐Wei 
Published: June 2024

AbstractREBa2Cu3O7‐x (REBCO) exhibits outstanding qualities such as a high irreversible field (7 T) and strong current‐carrying capacity (77 K, 106 A cm−2), making it ideal for high magnetic field applications such as fusion, accelerators, and nuclear magnetic resonance. However, the degradation of in‐field critical current density (Jc) due to vortex motion is a significant hurdle. Research indicates that improving vortex pinning can notably enhance Jc in REBCO, showing promise for its future high‐field applications. This review explores vortex pinning mechanisms, artificial pinning centers (APCs), and how environmental conditions affect pinning characteristics, highlighting advancements in vortex pinning for REBCO in magnetic fields. Different methods for introducing APCs are discussed and compared for evaluating their efficacy in achieving optimal nanoparticle distributions and consequent superconducting performance improvements, underscoring the importance of nano‐defect features (type, size, and distribution) in optimizing the superconducting properties of the REBCO. Additionally, the review tackles current challenges, shares recent research breakthroughs, and outlines future research directions for designing pinning landscapes to further improve REBCO performance.
SERPINC1, a new prognostic predictor of colon cancer, promote colon cancer progression through EMT
Authors: Le Zhenghong , Chen Shuran , Feng Yan , Lu Weichen , Liu Mulin 
Published: June 2024

AbstractBackgroundLiver metastasis of CRC is still the main cause of poor prognosis in patients with CRC. Previous studies have suggested that serpin family C member 1(SERPINC1) is involved in the development of a variety of tumours, but its effect on colorectal cancer progression has been poorly elucidated.MethodsBased on the GEO database, this study identifies the core gene SERPINC1 associated with liver metastasis in CRC. We used transcriptomic data and immunohistochemical staining to explore the expression of SERPINC1 in normal, cancer, and liver metastases tissue from CRC patients. Clinical data obtained from our hospital were used to explore the impact of SERPINC1 on the prognosis of colon cancer patients. Mechanistically, the biological functions exerted by SERPINC1 in CRC were predicted by bioinformatics, and the results were validated by the results of the experiments in vitro. Cell lines with knockdown of SERPINC1 were performed a series assay such as trans well, CCK‐8 and colony formation assay to explore the relationship between SERPINC1 and proliferation and metastasis of CRC cells. Finally, the effect of SERPINC1 on the sensitivity of colon cancer patients to immune checkpoint therapy was evaluated.ResultsIn CRC liver metastatic tissues, we found significantly high expression of SERPINC1. Briefly, 212 CRC cohorts showed that SERPINC1 was significantly associated with TNM stage and plasma CA19‐9 and CEA in CRC patients. Univariate and multivariate Cox demonstrated that SERPINC1 was significantly associated with 5‐year survival after radical surgery for colorectal cancer (p < 0.001). Bioinformatics predicted that SERPINC1 affects metastasis of colon cancer through epithelial‐mesenchymal transition (EMT). Colony formation assay and CCK‐8 assay showed that SERPINC1 promotes malignant proliferation of CRC cells, trans well assay showed that SERPINC1 promotes distant migratory behaviour of CRC cells and protein blotting assay showed that SERPINC1 may promote migration by promoting the TGF‐β1‐mediated EMT of CRC cells. In addition, several immunotherapy cohorts also reflected that the expression of SERPINC1 reduced the sensitivity of CRC patients to immune checkpoint therapy.ConclusionOur study identified SERPINC1 as a novel liver metastasis‐associated gene in CRC. Targeting SERPINC1 may be a novel therapeutic strategy for patients with liver metastases from CRC.
Primary Pulmonary Meningioma With Associated Multiple Micronodules: A Case Report With Comprehensive Diagnostic Overview
Authors: Zhu Daoqi , Ou Zhuan , Yan Guangning , Cao Jiawang , Xu Enwu 
Published: June 2024

ABSTRACTBackgroundPrimary pulmonary meningioma (PPM) is an exceedingly rare neoplasm originating in the meninges within the lung. Despite sharing similarities with its central nervous system (CNS) counterparts, PPM presents unique diagnostic challenges and therapeutic considerations owing to its infrequent occurrence.CaseThis case report describes a 73‐year‐old male who underwent chest computed tomography (CT), which revealed a mass in the posterior basal segment of the right lower lobe, suggestive of a low‐grade malignant tumor approximately 30–40 mm in size. Single‐port video‐assisted thoracoscopic surgery (VATS) was performed to resect the mass via localized lesion excision (lung wedge resection). Intraoperative frozen section pathology indicated a low‐grade malignant epithelial tumor, leading to a decision for maximal lung function preservation, considering the patient's advanced age. The surgical team opted for a localized excision to ensure negative margins. Histopathological analysis confirmed the diagnosis of epithelioid PPM, a rare subtype even among PPM cases (World Health Organization [WHO] Grade I). The patient was discharged 9 days after surgery without complications and resumed normal daily activities 1 month postoperatively. The rarity of PPM precludes a standardized treatment protocol, with surgical resection as the primary approach. However, the efficacy of adjunctive therapies remains uncertain due to limited evidence.ConclusionThis case report contributes to a better understanding of PPM and emphasizes the importance of a comprehensive diagnostic evaluation and individualized treatment planning for this rare entity.
Analysis and design of high‐frequency multiple‐output wireless power transfer system with load‐independent class‐E/F inverter
Authors: Wang Hanxiao , Komiyama Yutaro , Wei Xiuqin , Konishi Akihiro , Nguyen Kien , Sekiya Hiroo 
Published: June 2024

AbstractThis paper proposes a high‐frequency multiple‐receiver wireless power transfer (WPT) system with a load‐independent class‐E/F inverter. Each receiver has a post‐regulator, which changes the equivalent resistance seen from the inverter to obtain the necessary power for output voltage regulation. Because the load‐independent class‐E/F inverter generates constant AC current (
), the transmitter supplies the minimum required power to the receivers by the change of the equivalent resistances. Besides, the load‐independent inverter consistently achieves zero‐voltage switching (ZVS) without any control. As a result, no information feedback by wireless communication is necessary for output regulation and ZVS achievement, simplifying the system configuration and improving the transient response of the control. This paper presents analytical expressions of the proposed system. Besides, the experiment was carried out with a two‐receiver WPT system. The implemented system worked well by individual and independent output regulation of the post regulator at each receiver. The implemented WPT system achieved the power‐delivery efficiency of 83.4% at the 6.78 MHz transmission frequency and the total output power of 40 W.
Fluid resuscitation with balanced electrolyte solutions results in faster resolution of diabetic ketoacidosis than with 0.9% saline in adults – A systematic review and meta‐analysis
Authors: Szabó Gergő Vilmos , Szigetváry Csenge , Turan Caner , Engh Marie Anne , Terebessy Tamás , Fazekas Alíz , Farkas Nelli , Hegyi Péter , Molnár Zsolt 
Published: June 2024

AbstractFluid resuscitation during diabetic ketoacidosis (DKA) is most frequently performed with 0.9% saline despite its high chloride and sodium concentration. Balanced Electrolyte Solutions (BES) may prove a more physiological alternative, but convincing evidence is missing. We aimed to compare the efficacy of 0.9% saline to BES in DKA management. MEDLINE, Cochrane Library, and Embase databases were searched for relevant studies using predefined keywords (from inception to 27 November 2021). Relevant studies were those in which 0.9% saline (Saline‐group) was compared to BES (BES‐group) in adults admitted with DKA. Two reviewers independently extracted data and assessed the risk of bias. The primary outcome was time to DKA resolution (defined by each study individually), while the main secondary outcomes were changes in laboratory values, duration of insulin infusion, and mortality. We included seven randomized controlled trials and three observational studies with 1006 participants. The primary outcome was reported for 316 patients, and we found that BES resolves DKA faster than 0.9% saline with a mean difference (MD) of −5.36 [95% CI: −10.46, −0.26] hours. Post‐resuscitation chloride (MD: −4.26 [−6.97, −1.54] mmoL/L) and sodium (MD: −1.38 [−2.14, −0.62] mmoL/L) levels were significantly lower. In contrast, levels of post‐resuscitation bicarbonate (MD: 1.82 [0.75, 2.89] mmoL/L) were significantly elevated in the BES‐group compared to the Saline‐group. There was no statistically significant difference between the groups regarding the duration of parenteral insulin administration (MD: 0.16 [−3.03, 3.35] hours) or mortality (OR: −0.67 [0.12, 3.68]). Studies showed some concern or a high risk of bias, and the level of evidence for most outcomes was low. This meta‐analysis indicates that the use of BES resolves DKA faster than 0.9% saline. Therefore, DKA guidelines should consider BES instead of 0.9% saline as the first choice during fluid resuscitation.