bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lacrimal sac diffuse large B-cell lymphoma presenting as sudden-onset binocular diplopia
Authors: Jeri-Yabar Antoine , Vittini-Hernandez Liliana , Dev Bharati , Patel Marissa , Lin Meihuan 
Published: May 2024

Introduction: Diffuse large B-cell lymphoma (DLBCL) is a prevalent subtype of non-Hodgkin lymphoma (NHL) affecting predominantly elderly individuals. Case description: A 68-year-old man with a history of hypertension, hyperlipidaemia and a small pituitary gland tumour presented with sudden-onset binocular diplopia and right-eye blurry vision. A magnetic resonance imaging (MRI) of the brain revealed enhancing soft tissue in the right superolateral orbit inseparable from the lacrimal gland, extending medially to the right superior rectus muscle and soft tissue. Further scanning showed widespread metastasis to the bilateral retroperitoneal lymph nodes, adrenal gland, spine and lymph nodes in the neck. A biopsy of the lacrimal gland confirmed DLBCL. Conclusion: Primary lacrimal gland DLBCL is a rare and delayed diagnosis that often stems from the resemblance of its clinical manifestations to more benign conditions such as dacryocystitis, dacryostenosis or mucocele. Timely recognition and accurate diagnosis are essential for initiating appropriate treatment and improving patient outcomes.
Desafios do Microempreendedor Individual Florianense com relação à gestão financeira de seu negócio
Authors: Ramos de Passos Gomes Santiago Aiude , Viana Leal Lennilton 
Published: May 2024

O presente trabalho tem como objetivo apresentar um estudo sobre os principais desafios encontrados pelo Microempreendedor Individual de Floriano - Piauí com relação à gestão financeira de seu negócio, bem como identificar quais os fatores que os influenciaram a se tornar um Microempreendedor Individual, além de verificar se eles possuem noção da importância da gestão financeira para a sobrevivência de um negócio e analisar se o microempreendedor detém de noções básicas sobre assuntos da gestão financeira, verificando portanto se há associação entre ter o conhecimento em noções básicas de gestão financeira com outras variáveis. Sendo assim, ao final da pesquisa pretende-se resolver a seguinte problemática: Quais as principais dificuldades do Microempreendedor Individual na hora de fazer a gestão financeira do seu negócio? Para tanto, foi utilizado o método de pesquisa qualitativo com aplicação de questionário, onde através da análise de dados baseada na estatística descritiva foi possível concluir que o maior desafio apontado por eles encontra-se na separação das contas empresariais das contas pessoais. Além do mais, foi utilizada a estatística inferencial no cruzamento de dados de algumas variáveis da pesquisa onde conjuntamente foi aplicado o teste não-paramétrico Qui-quadrado, a fim de averiguar a associação estatisticamente significativa das variáveis. Logo, ao final da pesquisa fica evidente que não possuir noção básica de gestão e controle financeiro acarreta graves consequências. Portanto, a pesquisa contribui de forma significativa com a área de conhecimento finanças, demostrando a importância da gestão financeira para todo e qualquer negócio independente do porte ou área de atuação.
Cardiovascular Disease and Inpatient Complications in Turner Syndrome: A Propensity Score Analysis
Authors: Alzahrani Talal 
Published: May 2024

Abstract

Background:
Turner syndrome is a genetic disorder that occurs in female individuals and is characterized by the absence of 1 of the X chromosomes. This study examined the risk of cardiovascular disease and inpatient clinical outcomes in patients with Turner syndrome.

Methods:
Data were extracted from the Nationwide Inpatient Sample 2016 database. Propensity score analysis was used to match women with Turner syndrome and women without Turner syndrome admitted to a hospital in the same year to evaluate the risk of cardiovascular disease and inpatient clinical outcomes in patients with Turner syndrome.

Results:
After 1:1 matching, 710 women with Turner syndrome and 710 women without Turner syndrome were included in the final analysis. Compared with women without Turner syndrome, women with Turner syndrome were more likely to have a bicuspid aortic valve (9.4% vs 0.01%; P < .01), coarctation of the aorta (5.8% vs 0.3%; P < .01), atrial septal defect (6.1% vs 0.8%; P < .01), and patent ductus arteriosus (4.6% vs 0.6%; P < .01). Patients with Turner syndrome were more likely to have an aortic aneurysm (odds ratio [OR], 2.46 [95% CI, 1.02-5.98]; P = .046), ischemic heart disease (OR, 1.66 [95% CI, 1.10-2.5]; P = .02), heart failure (OR, 3.15 [95% CI, 1.99-4.99]; P < .01), and atrial fibrillation or flutter (OR, 2.48 [95% CI, 1.42-4.34]; P < .01). Patients with Turner syndrome were more likely to have pulmonary arterial hypertension (OR, 2.12 [95% CI, 1.08-4.14]; P = .03) and acute kidney injury (OR, 1.60 [95% CI, 1.06-2.42]; P = .03) and to require mechanical ventilation (OR, 1.66 [95% CI, 1.04-2.68]; P = .04).

Conclusion:
Turner syndrome is associated with an increased rate of cardiovascular disease and inpatient complications. These findings suggest that patients with Turner syndrome should be screened and monitored closely for cardiovascular disease and inpatient complications.
Study the hepatoprotective effect of the methanolic extract of Plumbago auriculata Lam. against CCl4-induced hepatocyte damage in mice
Authors: Ahmed Massara Nazar , Khamees Amjed Haseeb 
Published: May 2024

The liver is an important organ in the body; its diseases are considered the major causes of morbidity and mortality around the world. Hepatotoxic chemicals cause damage to liver cells. Medicinal plants have a powerful hepatoprotective effect. This study has been aimed to assess the potential hepatoprotective effect of the methanolic extract of Plumbago auriculata Lam. against carbon tetrachloride (CCl4)- induced hepatocyte damage in albino mice. The methanolic extract of the plant was subjected to preliminary phytochemical analysis to determine the presence of secondary metabolites according to standard protocols. The acute toxicity study was carried out to measure the LD50. Swiss albino mice were divided into 4 groups treated intraperitoneally (IP) once daily for 7 days; the first group was a negative control, while the second group, considered as a CCl4 model, received a single dose of carbon tetrachloride during the last day. The third group received 500 mg/kg of body weight of methanolic extract of P. auriculata, and the last group received 100 mg/kg of body weight of standard silymarin, after 2 h of treatment, on the last day, all animals (except negative control group) have received CCl4 at a dose of 1 mL/kg of body weight. Biochemical analysis of collected blood and histopathological examination were performed. Results revealed that the preliminary phytochemical screening of the methanolic extract of the plant confirmed the presence of many biologically active secondary metabolites like flavonoids, steroids, terpenoids, saponins, glycosides and phenols and LD50 of the extract was 2.5 g/kg. The CCl4- intoxicated mice showed an increase in biochemical enzyme levels (ALT and AST) compared with the negative control group. The extract of 500 mg/kg revealed a significant reduction (p ? 0.05) in enzyme activities. The histopathological analysis of plant extract and silymarin-treated groups revealed a decrease in the pathological features compared with the CCl4-intoxicated group. It was concluded that the extract of P. auriculata has a significant effect on hepatoprotection against CCl4-induced hepatocyte damage and this may be because of the combined effects of the bioactive compositions of plant extract.
Dynamism of context: A case of joke interpretation
Authors: Jodłowiec Maria , Piskorska Agnieszka 
Published: May 2024

Abstract
While the recognition of context as a dynamic construct is pervasive, the process of selecting context during utterance comprehension in real time remains largely unexamined. This paper addresses this issue by exploring the dynamism of context as part of joke interpretation. We assume a relevance-theoretic definition of context understood as a set of mental representations involved in inferential processes that operate on a propositionally incomplete linguistic form and yield a speaker-intended meaning, consisting of the explicit and implicit import. We also adopt a model of joke comprehension combining the standard notion of incongruity resolution with that of weak communication, positing that when the punchline comes there is a broad array of assumptions that suddenly become manifest to the hearer, as a result of which he experiences an effect of inferential overload. This effect hinges on the ability to obtain access to, or to inferentially construct contextual assumptions that were previously not immediately accessible to the hearer or not represented in their cognitive resources at all. By analysing jokes of various structure (with or without a build-up, one-liners) we explore details of the dynamism of context selection and construction, in which the hearer’s encyclopaedic knowledge is essential. We provide arguments in favour of the view of context as an entity dependent on the hearer’s mental representations, inferential abilities and the universal drive to maximize relevance in utterance comprehension.
“Be Yo’self. It’s Just a Show”: Performing Community through the Comic Grotesque in Branden Jacobs-Jenkins’s Neighbors
Authors: Saddik Annette J. 
Published: May 2024

Abstract
Branden Jacobs-Jenkins’s play Neighbors, which premiered at the Public Theater in 2010, explores the history of Black representation in the theater and, subsequently, the performance of Black identity in the US through its depiction of a complex and contradictory minstrelsy that cannot easily be classified as satirical or subversive. Generating what Jacobs-Jenkins has called “wrong laughter” through contradiction, ambiguity, and ambivalence, Neighbors engages the unstable space of the comic grotesque in order to open up pathways for something new to emerge. In this play, the figure of the clown – a grotesque outlaw who moves between, within, across, and beyond boundaries – becomes a key destabilizing figure as the grotesque body becomes a site for transformation through its contradictions, oozing inconsistency and excess, and allowing a potential space for regeneration and renewal through instability and failure when the stable and the rational have failed. In its embrace of clowning and the comic grotesque, Neighbors questions the stable notion of “community,” particularly in terms of racial and historical identity, and exposes the contradictions of closed constructions, creating a space beyond the boundaries of rational discourse that may begin to engage a more complex reality.
Concerns of osteopathic medical students during the COVID-19 pandemic
Authors: Hanna Odeh , Vinyard Christopher J. , Casapulla Sharon 
Published: May 2024

Abstract

Objectives
This study aims to quantify the areas of most concern in medical students in relation to their residency application in the setting of the COVID-19 pandemic and to identify risk factors for all that cause concern and specific areas of concern in a population with well-established high rates of anxiety at baseline. The COVID-19 pandemic introduced sweeping changes to medical education that had wide-ranging effects on medical students and their applications for medical residencies.

Methods
In August 2020, we utilized a cross-sectional study to quantify student’s areas of concern related to residency application related to the COVID-19 pandemic. We asked participants to rate their levels of concern in 15 different aspects related to medical residency applications and the perceived impact that COVID-19 had on each.

Results
The survey was distributed to 984 osteopathic medical students, with 255 complete responses. The three areas of greatest impact were shadowing opportunities (4.15), volunteer opportunities (4.09), and conferencing opportunities (4.09). The most salient demographic variables were year in school, sex, and locale. Females reported higher levels of concern across all categories in the study compared to males, with statistical significance across all categories (all p<0.05, Range d=0.16 to 0.43), except for letters of recommendation and sub-internships.

Conclusions
The areas of most concern identified in our study were consistent with prior studies and may implicate the pressures that female medical students may feel compared to their male counterparts. The underlying cause(s) may be subject to future research.
ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
Authors: Wang Hao , Zhao Wei , Wang Daorong , Chen Jin 
Published: May 2024

Abstract
Herein, we elucidate the potential role of ANO6 (TMEM16F) in gastrointestinal stromal tumors (GISTs). ANO6 expression in GIST and adjacent normal tissues was determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting. Cell proliferation, apoptosis, and pyroptosis were examined utilizing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, terminal deoxynucleotidyl transferase dUTP Nick-End Labeling staining, and flow cytometry. In addition, the total iron and Fe2+ levels were assessed. IL-18 and IL-1β levels were also evaluated. Lipid reactive oxygen species (ROS), cystine (Cys), glutathione (GSH), and glutathione peroxidase 4 (GPX4) levels were evaluated using appropriate kits. Ferroptotic markers, including Ptgs2, Chac1, SLC7A11, and SLC3A2, were analyzed by RT-qPCR, western blotting, and immunohistochemistry. ANO6 expression decreased in GIST tissues. ANO6-plasmid inhibits proliferation, induces apoptosis, and promotes pyroptosis in GIST-T1 and GIST-T1 IR cells. The ANO6-plasmid induced ferroptosis, as confirmed by enhanced lipid ROS levels, increased intracellular concentrations of total iron and Fe2+, promoted Ptgs2 and Chac1 expression, reduced Cys, GSH, and GPX4 levels, and downregulated SLC7A11 and SLC3A2 expression after in vitro and in vivo treatment with ANO6-plasmid. Moreover, the ANO6-plasmid inhibited GIST growth in vivo. Therefore, ANO6 may be a promising therapeutic target for blocking the development of GIST via the induction of apoptosis, pyroptosis, and ferroptosis.
Metaphors across cultures
Authors: Banaruee Hassan , Farsani Danyal , Khatin-Zadeh Omid , Eskandari Zahra 
Published: May 2024

Abstract
The way and degree to which people in different cultures consider a metaphor to be appropriate, acceptable, or apt has been the subject of controversy in recent decades. According to structure-mapping models, metaphors are understood by mapping relations from the base domain to relations in the target domain. However, previous research lacks literature on cross-cultural contexts and differences in the degree of acceptability of metaphors in different cultures. To address this gap, in this study we examined cross-cultural differences in metaphor aptness among participants from three different cultures. We developed two questionnaires, an acceptability judgment-task and a parallel-relation test using the COCA (English), PLDB (Persian), and KorAP (German) corpus databases. The results suggest striking differences in the acceptance of a metaphor in different cultures where the vehicle of a metaphor is not present. It is suggested that metaphors are considered apt through the process of categorizing the salient features that are considered structurally similar. This idea is partially consistent with studies that support class-inclusion models which suggest that hearers place the topic of a metaphor in a category in which the vehicle fits. The absence of a domain (whether topic or vehicle) may lead to unacceptability of a metaphor. Lack of cultural background in the use of these words hinders the process of finding a salient feature between them and the counter domain in a metaphor to form an appropriate alignment.
Compressive strength of waste-derived cementitious composites using machine learning
Authors: Tian Qiong , Lu Yijun , Zhou Ji , Song Shutong , Yang Liming , Cheng Tao , Huang Jiandong 
Published: May 2024

Abstract
Marble cement (MC) is a new binding material for concrete, and the strength assessment of the resulting materials is the subject of this investigation. MC was tested in combination with rice husk ash (RHA) and fly ash (FA) to uncover its full potential. Machine learning (ML) algorithms can help with the formulation of better MC-based concrete. ML models that could predict the compressive strength (CS) of MC-based concrete that contained FA and RHA were built. Gene expression programming (GEP) and multi-expression programming (MEP) were used to build these models. Additionally, models were evaluated by calculating R
2 values, carrying out statistical tests, creating Taylor’s diagram, and comparing theoretical and experimental readings. When comparing the MEP and GEP models, MEP yielded a slightly better-fitted model and better prediction performance (R
2 = 0.96, mean absolute error = 0.646, root mean square error = 0.900, and Nash–Sutcliffe efficiency = 0.960). According to the sensitivity analysis, the prediction of CS was most affected by curing age and MC content, then by FA and RHA contents. Incorporating waste materials such as marble powder, RHA, and FA into building materials can help reduce environmental impacts and encourage sustainable development.
Can Chatbots Ever Provide More Social Connection Than Humans?
Authors: Folk Dunigan , Yu Stephanie , Dunn Elizabeth 
Published: May 2024

Around the world, hundreds of millions of people have used social chatbots designed to provide companionship to their users. But can people reap genuine social benefits from interacting with chatbots? In Studies 1a&b (pre-registered; N=801), participants shared good news with a supportive or less supportive interaction partner whom they believed was either a chatbot or a human. Participants’ feelings following the interaction were influenced by their partner’s response style, but not by whether their partner was human. In Study 2 (pre-registered, N=201), participants derived more social connection from having a supportive conversation with ChatGPT than with a less supportive human. In a final pre-registered study (Study 3; N=401), we identified an important boundary condition, demonstrating that the relative benefits of interacting with chatbots (vs. humans) may be reduced when they claim too much humanity.
La tributación ambiental en Guatemala
Authors: Menéndez Ochoa Ángel Estuardo 
Published: May 2024

Las sociedades modernas están evolucionando en cuanto a la utilización del Derecho Tributario no solo para fines recaudatorios, sino para lograr la protección de bienes jurídicos que, en muchos casos, su protección es ordenada en las normas constitucionales de estas sociedades. Sobre ello indica Ortega (2005):
Que el Derecho tributario puede también tener una finalidad la protección social y procuración de seguridad ante los nuevos peligros, es indudable que debe manejar nuevos conceptos, tal es el caso del concepto de «bien jurídico protegido» que se postula tanto en el Derecho penal, como en Derecho administrativo sancionador…la estructura del hecho imponible habrá de construirse teniendo en cuenta, en primer lugar, la protección de esos bienes jurídicos y sólo secundariamente en función de otros fines. Igualmente, los criterios de cuantificación del tributo deben ser acordes con ese propósito de «disuasión» o «desincentivación» de conductas lesivas y peligrosas, y no considerar preferentemente la capacidad económica de los particulares.

Indica Ingunza (2009), que:
Desde que hemos existido como humanidad, se ha venido alterando los ecosistemas, pero desde que se inició la Era Industrial, la escala de esas alteraciones ha sido cada vez mayor debido, en particular, al crecimiento demográfico, al creciente consumo de energía, la intensidad del uso del suelo, y al desempeño de otras actividades humanas que han ido lacerando al planeta cuyo resultado es la acumulación de calor.

Una breve referencia al surgimiento del movimiento que resaltaba la importancia de la protección del medio ambiente, Küng (2000) indica:
Surgieron en los años setenta los primeros Verdes, que pusieron la ecología en el centro de su programa y exigieron una transformación radical de la sociedad industrial, los partidos establecidos adoptaron una actitud de rechazo, lo que condujo a que en 1980 se formara el partido de “los Verdes”, que, con valores fundamentales como “ecológico-social, democracia de base, no violencia”. Ellos son expresión del cambio de paradigma, de modernidad a una posmodernidad no dispuesta ya a hacer de la naturaleza simple mercancía.
THE BANISHMENT DISCOURSE AND THE WESTERN MACHINE OF MAKING BARBARIANS
Authors: Cardoso Luis Gustavo , Kozicki Katya 
Published: May 2024

This article presents an interdisciplinary analysis of the banishment discourse in the Western world during the Classical Greek antiquity (8th century B.C. to the 4th century B.C.) from a narrative and historical, theoretical perspective. The text presented here is also marked by its authors' Brazilian nationality and legal tradition, considering that the local and actual legal institutes reveal an unequivocal bond to the ancient tradition. Focusing on the legal institutes of extradition, deportation, expulsion, and surrender, this study inquiries the moral and political effects of banishment as a critical concept of international law and political life. The analytical method resorts on a case-by-case basis to historical narrative and interpretation of the consequences of displacement. It hypothesizes that the banishment discourse produces a division between a We and an Other and eventually irrupts social rupture and exile. This research proposes a broader and historical view of international law while employing the theoretical tool of auditorium, created by Perelman and Olbrechts-Tyteca. Thence concludes that the discourse of banishment is responsible for making the so-called barbarians in the Western imaginary, which works as a device and a fundamental argument for a permanent distinction towards the foreign one.
Study of lithium carbonate and ascorbate proliferative properties on transplantable Lewis lung carcinoma metastasis model
Authors: Frolova D. E. , Torshin I. Yu. , Rastashansky V. V. , Filimonova M. V. , Gromova O. A. 
Published: May 2024

Objective: to study the antitumor effects of organic lithium salt (lithium ascorbate) in different doses in comparison with inorganic lithium salt (carbonate).Material and methods. Two series of experiments were carried out on the effect of lithium preparations on the dynamics of transplantable Lewis lung carcinoma (LLC) growth and metastasis in F1 mice (CBA × C57Bl/6j). In the first series, a comparative study of the effects of different lithium ascorbate doses (1 and 10 mg/kg/day based on elemental lithium) was performed, and in the second series, a comparison was made of the effects of lithium ascorbate and carbonate when used at the same dose (5 mg/kg/day).Results. Significant antitumor effects were found for lithium ascorbate lower doses (1 and 5 mg/kg/day). A statistically significant antitumor effect of lithium ascorbate was observed from Day 10 throughout the entire observation period (tumor growth inhibition index (TGII) 30–40%). The antitumor effect of lithium carbonate in this experiment was less pronounced and stable (TGII 20–30%). No antimetastatic effect was observed with both preparations.Conclusion. Subchronic intragastric administration of lithium ascorbate and carbonate to tumor-bearing animals at a daily dose of 5 mg/kg, an antitumor effect is observed, manifested by LLC growth inhibition. Effective and safe antitumor doses of lithium ascorbate are in the range of 1–5 mg/kg.