bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and antifungal evaluation of novel dicyanoderivatives of rhodanine
Authors: Insuasty Braulio , Insuasty Alberto , Tigreros Alexis , Quiroga Jairo , Abonia Rodrigo , Nogueras Manuel , Cobo Justo , Derita Marcos , Zacchino Susana 
Published: December 2010

AbstractThis work describes the synthesis and antifungal evaluation of 5‐arylidene‐(Z)‐2‐(1,1‐dicyanomethylene)‐1,3‐thiazol‐4‐ones 5 obtained from the reaction of 2‐(1,1‐dicyanomethylene)‐1,3‐thiazol‐4‐one 3 and benzaldehydes 4. The starting material 3 was synthesized by a condensation reaction of rhodanine 1 and malononitrile 2. The structures of the obtained products were established by IR, NMR, mass spectrometry, and elemental analysis. J. Heterocyclic Chem., (2011).
An analytical study of undoped symmetric double gate MOSFET (SDG)
Authors: Singh Ajay Kumar 
Published: December 2010

AbstractIn the present paper, compact analytical models for the threshold voltage, threshold voltage roll‐off and subthreshold swing of undoped symmetrical double‐gate MOSFET have been developed based on analytical solution of two‐dimensional Poisson's equation for potential distribution. The developed models include drain‐induced barrier lowering (DIBL) through theVds‐dependent parameter. The calculated threshold voltage value, obtained from the proposed model, shows a good agreement with the experimental and published results. The simulation results for potential show that the conduction is highly confined to the surfaces. The threshold voltage sensitivity to the thickness is found to be approximately 0.2%. Model prediction indicates that subthreshold slope is not linearly related to DIBL parameter for thick silicon film. The proposed analytical models not only provide useful insight into behavior of symmetrical DG MOSFETs but also serve as the basis for compact modeling. Copyright © 2010 John Wiley & Sons, Ltd.
Oncolytic vesicular stomatitis virus administered by isolated limb perfusion suppresses osteosarcoma growth
Authors: Kubo Tadahiko , Shimose Shoji , Matsuo Toshihiro , Fujimori Jun , Sakaguchi Takemasa , Yamaki Minoru , Shinozaki Katsunori , Woo Savio L.C. , Ochi Mitsuo 
Published: December 2010

AbstractA significant limitation to oncolytic virotherapy in vivo is the lack of a clinically relevant means of delivering the virus. We evaluated the oncolytic activity of vesicular stomatitis virus (VSV) in human osteosarcoma cells and explored isolated limb perfusion (ILP) as a novel oncolytic virus delivery system to extremity sarcoma in immune‐competent rats. Human and rat osteosarcoma cells transduced with rVSV‐lacZ uniformly expressed β‐gal. VSV was fully capable of replicating its RNA genome in all osteosarcoma cell lines, and efficiently killed them in time‐ and dose‐dependent manners, whereas normal bone marrow stromal cells were refractory to the virus. VSV delivered by ILP inhibited growth of osteosarcoma xenografts more potently than that injected intravenously and intratumorally in the hind limb of immune‐competent rats. Histopathological sections of tumor lesions treated by ILP‐delivered VSV showed positive for VSV‐G protein. There were no VSV‐G expressions in perfused leg muscle, nonperfused leg muscle, brain, lung, and liver in VSV‐treated rats. Our findings show efficient VSV gene expression and replication in osteosarcoma cells, suggesting that osteosarcoma may be a promising target for oncolytic virotherapy with VSV. Furthermore, we firstly showed that ILP of VSV against extremity sarcoma caused antitumor activity. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 29:795–800, 2011
Extending limits of resection for metastatic colorectal cancer: Risk benefit ratio
Authors: Yang Anthony D. , Brouquet Antoine , Vauthey Jean Nicolas 
Published: December 2010

AbstractImprovements in treatment strategies and a better knowledge of tumor biology have contributed to an increase in the number of patients with colorectal liver metastases (CLM) who are candidate for surgery. These progresses are on going and the introduction of effective systemic therapy agents contributes further to the increase in the resectability of patients with advanced CLM. J. Surg. Oncol. 2010;102:996–1001. © 2010 Wiley‐Liss, Inc.
Use of clinical score to stage and predict outcome of hepatic resection of metastatic colorectal cancer
Authors: Feroci Francesco , Fong Yuman 
Published: December 2010

AbstractAll metastatic colorectal cancer cases are classified as stage IV by AJCC staging, yet cases differ widely as to prognosis. Criteria are needed to select patients for surgery, for adjuvant therapy, and for clinical trials. In this paper we review the various prognostic scoring systems proposed, including the most widely used clinical risk score. Validation and practical uses of these scoring systems are also discussed. J. Surg. Oncol. 2010;102:914–921. © 2010 Wiley‐Liss, Inc.
Role of intra‐arterial hepatic chemotherapy in the treatment of colorectal cancer metastases
Authors: Kingham T. Peter , D'Angelica Michael , Kemeny Nancy E. 
Published: December 2010

AbstractHepatic metastases are common with colorectal cancer. The primary blood supply to hepatic metastases is the hepatic artery. Regional chemotherapy utilizing the hepatic artery is one treatment option for liver metastases. The advantage of hepatic arterial chemotherapy is that high concentrations of the therapeutic drug are obtained in the liver with minimal systemic toxicity. Recently, systemic chemotherapy regimens have been added to hepatic arterial infusional chemotherapy to treat hepatic metastases. Due to the high response rates in the liver, resection rates are increasing in patients originally thought to have unresectable liver disease. Hepatic arterial chemotherapy has also been used in the adjuvant setting after resection of all liver metastases in order to minimize hepatic recurrences. The role of hepatic arterial infusional therapy in treating hepatic colorectal metastases includes treating patients with both resectable and unresectable metastases in the adjuvant, neoadjuvant, or palliative settings. J. Surg. Oncol. 2010;102:988–995. © 2010 Wiley‐Liss, Inc.
Topology optimization for nano‐photonics
Authors: Jensen J.S. , Sigmund O. 
Published: December 2010

AbstractTopology optimization is a computational tool that can be used for the systematic design of photonic crystals, waveguides, resonators, filters and plasmonics. The method was originally developed for mechanical design problems but has within the last six years been applied to a range of photonics applications. Topology optimization may be based on finite element and finite difference type modeling methods in both frequency and time domain. The basic idea is that the material density of each element or grid point is a design variable, hence the geometry is parameterized in a pixel‐like fashion. The optimization problem is efficiently solved using mathematical programming‐based optimization methods and analytical gradient calculations. The paper reviews the basic procedures behind topology optimization, a large number of applications ranging from photonic crystal design to surface plasmonic devices, and lists some of the future challenges in non‐linear applications.
Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water matrices
Authors: Botitsi Helen V. , Garbis Spiros D. , Economou Anastasios , Tsipi Despina F. 
Published: December 2010

AbstractAnalysis of pesticides and their metabolites in food and water matrices continues to be an active research area closely related to food safety and environmental issues. This review discusses the most widely applied mass spectrometric (MS) approaches to pesticide residues analysis over the last few years. The main techniques for sample preparation remain solvent extraction and solid‐phase extraction. The QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) approach is being increasingly used for the development of multi‐class pesticide residues methods in various sample matrices. MS detectors—triple quadrupole (QqQ), ion‐trap (IT), quadrupole linear ion trap (QqLIT), time‐of‐flight (TOF), and quadrupole time‐of‐flight (QqTOF)—have been established as powerful analytical tools sharing a primary role in the detection/quantification and/or identification/confirmation of pesticides and their metabolites. Recent developments in analytical instrumentation have enabled coupling of ultra‐performance liquid chromatography (UPLC) and fast gas chromatography (GC) with MS detectors, and faster analysis for a greater number of pesticides. The newly developed “ambient‐ionization” MS techniques (e.g., desorption electrospray ionization, DESI, and direct analysis in real time, DART) hyphenated with high‐resolution MS platforms without liquid chromatography separation, and sometimes with minimum pre‐treatment, have shown potential for pesticide residue screening. The recently introduced Orbitrap mass spectrometers can provide high resolving power and mass accuracy, to tackle complex analytical problems involved in pesticide residue analysis. © 2010 Wiley Periodicals, Inc., Mass Spec Rev 30:907–939, 2011
A discontinuous enrichment method for variable‐coefficient advection–diffusion at high Péclet number
Authors: Kalashnikova I. , Tezaur R. , Farhat C. 
Published: December 2010

AbstractA discontinuous Galerkin method with Lagrange multipliers is presented for the solution of variable‐coefficient advection–diffusion problems at high Péclet number. In this method, the standard finite element polynomial approximation is enriched within each element with free‐space solutions of a local, constant‐coefficient, homogeneous counterpart of the governing partial differential equation. Hence in the two‐dimensional case, the enrichment functions are exponentials, each exhibiting a sharp gradient in a carefully chosen flow direction. The continuity of the enriched approximation across the element interfaces is enforced weakly by the aforementioned Lagrange multipliers. Numerical results obtained for two benchmark problems demonstrate that elements based on the proposed discretization method are far more competitive for variable‐coefficient advection–diffusion analysis in the high Péclet number regime than their standard Galerkin and stabilized finite element comparables. Copyright © 2010 John Wiley & Sons, Ltd.
Increasing rates of breast cancer and cardiac surveillance among high‐risk survivors of childhood Hodgkin lymphoma following a mailed, one‐page survivorship care plan
Authors: Oeffinger Kevin C. , Hudson Melissa M. , Mertens Ann C. , Smith Stephanie M. , Mitby Pauline A. , Eshelman‐Kent Debra A. , Ford Jennifer S. , Jones Judith K. , Kamani Sharmila , Robison Leslie L. 
Published: December 2010

AbstractBackgroundHodgkin lymphoma (HL) survivors face substantially elevated risks of breast cancer and cardiovascular disease. They and their physicians are often unaware of these risks and surveillance recommendations.ProcedureA prospective one‐arm study was conducted among a random sample of 72 HL survivors, ages 27–55 years, participating in the Childhood Cancer Survivor Study (CCSS) who were at increased risk for breast cancer and/or cardiomyopathy and had not had a screening mammogram or echocardiogram, respectively, within the prior 2 years. A one‐page survivorship care plan with recommendations for surveillance was mailed to participants. In addition, survivors' primary physicians were contacted and provided patient‐specific information and a web‐based Virtual Information Center was made available for both survivors and physicians. Outcomes were assessed by telephone 6 months after the intervention.ResultsThe survivor participation (62/72; 86%) and 6‐month retention (56/61; 92%) rates were high. Tension and anxiety, measured by the Profile of Mood States, did not increase following risk notification; 91% of survivors described their reactions to receiving the information in positive terms. At 6 months, 41% of survivors reported having completed the recommended mammogram; 20% reported having an echocardiogram (females 30%, males 10%). Only 29% of survivors visited the website. Nine physicians enrolled, and none used the study resources.ConclusionA mailed, personalized survivorship care plan was effective in communicating risk and increasing compliance with recommended medical surveillance. Internet‐ and telephone‐based strategies to communicate risk were not utilized by survivors or physicians. Pediatr Blood Cancer 2011;56:818–824. © 2011 Wiley‐Liss, Inc.
Development and reliability of the comprehensive crisis plan checklist
Authors: Aspiranti Kathleen B. , Pelchar Taylor K. , McCLeary Daniel F. , Bain Sherry K. , Foster Lisa N. 
Published: December 2010

AbstractIt is of vital importance that children are educated in a safe environment. Every school needs to have a well‐developed crisis management document containing plans for prevention, intervention, and postvention. We developed the Comprehensive Crisis Plan Checklist (CCPC) to serve as a valuable tool that can be used to assist practitioners with evaluation of their school crisis management plans. To use the CCPC, school personnel should match the items on the checklist to elements in their developing or existing crisis plan to determine missing elements. By comparing a school or district crisis plan to the CCPC, practitioners or school personnel will be able to determine strengths and weaknesses of the plan as well as provide feedback for making their plans more complete and comprehensive. In this study, we describe the development of the CCPC and report on reliability data using this checklist. © 2010 Wiley Periodicals, Inc.
Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures
Authors: Kuglstatter Andreas , Wong April , Tsing Stan , Lee Simon W. , Lou Yan , Villaseñor Armando G. , Bradshaw J. Michael , Shaw David , Barnett Jim W. , Browner Michelle F. 
Published: December 2010

AbstractBruton's tyrosine kinase (BTK) plays a key role in B cell receptor signaling and is considered a promising drug target for lymphoma and inflammatory diseases. We have determined the X‐ray crystal structures of BTK kinase domain in complex with six inhibitors from distinct chemical classes. Five different BTK protein conformations are stabilized by the bound inhibitors, providing insights into the structural flexibility of the Gly‐rich loop, helix C, the DFG sequence, and activation loop. The conformational changes occur independent of activation loop phosphorylation and do not correlate with the structurally unchanged WEI motif in the Src homology 2‐kinase domain linker. Two novel activation loop conformations and an atypical DFG conformation are observed representing unique inactive states of BTK. Two regions within the activation loop are shown to structurally transform between 310‐ and α‐helices, one of which collapses into the adenosine‐5′‐triphosphate binding pocket. The first crystal structure of a Tec kinase family member in the pharmacologically important DFG‐out conformation and bound to a type II kinase inhibitor is described. The different protein conformations observed provide insights into the structural flexibility of BTK, the molecular basis of its regulation, and the structure‐based design of specific inhibitors.
Spatially resolved Raman and cathodoluminescence probes in electronic materials: Basics and applications
Authors: Pezzotti Giuseppe 
Published: December 2010

AbstractSpatially resolved spectroscopy of both Raman and cathodoluminescence (CL) emissions represent a quite powerful characterization method in electronics. In this paper, the underlying physics that dictates the different characteristics of Raman and CL probes is revisited, deepened, and further interpreted in order to clarify how the different nature of those probes enables one bringing about different sets of complementary information. Furthermore, it is inquired into the causes for which data collected by the two different spectroscopic methods on the same material or device may, at a first glance, appear inconsistent to each other and, for some aspects, contradictory. Such differences and contradictions are then shown to disappear once the different nature of the two probes, especially with respect to their spatial response and morphology, is clarified and properly taken into account. Emphasis is finally placed on quantitatively describing the spatial response of Raman and CL probes and to apply such knowledge to elucidate the behavior of electronic materials. The two types of light emission are described according to a common formalism, which details their respective probe response functions in the three‐dimensional space. Practical applications of Raman and CL spectroscopy to resolve highly graded fields of crystal orientation and elastic stress/strain in paradigm electronic materials are finally shown and compared.
Diffusion length determination in solar grade silicon by room temperature photoluminescence measurements
Authors: Sayad Y. , Blanc D. , Kaminski A. , Bremond G. , Lemiti M. 
Published: December 2010

AbstractMinority carrier lifetime (τ) and diffusion length (L) are the most important electrical parameters to qualify silicon for photovoltaic applications. Amongst the available techniques for measuring this parameter, photoluminescence has regained interest as it can be done on raw material as well as on completed solar cells in a non destructive way. Although very efficient mapping systems can provide fast information on multicrystalline samples most quantitative measurements require a calibration that is normally achieved by correlation with other techniques like photoconductance decay. In this paper, we show that L may be evaluated in a simple way from the dependence of the room temperature photoluminescence signal on the excitation beam intensity using an analytical model based on 1D carrier diffusion. Using this 1D model, the diffusion length was calculated in photovoltaic grade silicon materials without calibration by external technique. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Electrical properties of polysilicon nanowires for device applications
Authors: Demami F. , Rogel R. , Salaün A.‐C. , Pichon L. 
Published: December 2010

AbstractPolysilicon nanowires are synthesized using the well known and low cost technique commonly used in microelectronic industry: the sidewall spacer formation technique. Polysilicon layer is deposited by Low Pressure Chemical Vapour Deposition technique on SiO2 wall patterned by conventional UV lithography technique. Polysilicon film is then plasma etched. Accurate control of the etching rate leads to the formation of nanometric size sidewall spacers with a curvature radius as low as 100 nm used as polysilicon nanowires. These polysilicon nanowires are first integrated into the fabrication of electrical devices as resistors and electrical properties are studied in function of in situ phosphorus doping levels. I(T) measurements show that polysilicon nanowires dark conductivity is thermally activated according to the Seto's theory. In addition, field effect transistors made with such polysilicon nanowires used as channel region highlight promising field effect behaviour. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Growth rate model and doping metrology by atom probe tomography in silicon nanowire
Authors: Chen W. H. , Lardé R. , Cadel E. , Xu T. , Grandidier B. , Nys J. P. , Stiévenard D. , Pareige P. 
Published: December 2010

AbstractSilicon nanowires (SiNWs) with different surface number density are fabricated using Chemical Vapor Deposition (CVD) method by controlling the catalyst droplet number density with in‐situ evaporation. For comparison, another type of SiNWs is fabricated by Molecular Beam Epitaxy (MBE) method. To study these two types of SiNWs a general growth rate model is presented. The fit curves from this model are consistent with our experimental data. In both growing conditions the SiNW growth rate as a function of their diameter are compared and discussed. The p‐type SiNWs have also been prepared by adding diborane into precursor. The doping metrology in an individual SiNW is realized by laser assisted Atom Probe Tomography (APT). We have shown that the doping atoms (e.g. B) can incorporate into SiNW and an accurate quantification can be given (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Analytical modelling and experimental verification of the three‐dimensional current distribution on the top surface of silicon solar cells operating under concentrated sunlight
Authors: Costagliola Maurizio , Riccio Michele , Irace Andrea , Breglio Gianluca , Daliento Santolo 
Published: December 2010

AbstractThe approximation that the current is constant in any point of the emitter is not true for solar cells operating under concentrated sunlight. The transverse paths followed by photogenerated carriers to reach metal grid electrodes causes voltage drops leading to non‐uniform distributed surface potential and a consequent reduction of the conversion efficiency. Moreover, concentrating lens often provide non‐uniform light intensity thus worsening non‐uniform current distribution. The correct design of surface geometry of the cell (metal grid, emitter depth, sheet resistance) should always take into account the above effects. Unfortunately a lack of reliable models still exists. In this paper we analytically solve the three‐dimensional semiconductor equations with proper boundary conditions and taking into account, as source term, a distributed generation contribute. The reliability of the model has been tested by numerical simulations and experimentally verified with a lock‐in thermography technique (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Stimulated emission from anthracene aggregates in fluorene crystals fabricated by cell method
Authors: Mizuno Hitoshi , Aoki‐Matsumoto Tamao , Ichida Masao , Ando Hiroaki , Hirai Takeshi , Mizuno Ken‐ichi 
Published: December 2010

AbstractIn fluorene(80%)–anthracene(20%) mixed crystals, mainly observed luminescence is broad D2 bands, which originates from an excitation state localized on two anthracene molecules and is accompanied by lattice relaxation. Under high intensity excitation, several sharp luminescence lines emerged in the high energy side of the D2 0–1 bands and their intensity increased superlinearly with excitation intensity. The decay time of the luminescence lines is 30 ps, which is two orders of magnitude smaller than decay time under low intensity excitation. These results suggest that sharp luminescence lines are stimulated luminescence from D2 centers. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)