bluuebunny/crossref_metadata_2025_split huggingface dataset:
Update on Cancer and Central Nervous System Tumor Surveillance in Pediatric NF2-, SMARCB1-, and LZTR1-Related Schwannomatosis
Authors: Perrino Melissa R. , Jongmans Marjolijn C. J. , Tomlinson Gail E. , Greer Mary-Louise C. , Scollon Sarah R. , Mitchell Sarah G. , Hansford Jordan R. , Schultz Kris Ann P. , Kohlmann Wendy K. , Kalish Jennifer M. , MacFarland Suzanne P. , Das Anirban , Maxwell Kara N. , Pfister Stefan M. , Weksberg Rosanna , Michaeli Orli , Tabori Uri , Ney Gina M. , Lupo Philip J. , Brzezinski Jack J. , Stewart Douglas R. , Woodward Emma R. , Kratz Christian P. 
Published: February 2025

Abstract
Schwannomatoses (SWN) are distinct cancer predisposition syndromes caused by germline pathogenic variants in the genes NF2, SMARCB1, or LZTR1. There is significant clinical overlap between these syndromes with the hallmark of increased risk for cranial, spinal and peripheral schwannomas. Neurofibromatosis type 2 was recently renamed as NF2-related SWN and is the most common SWN syndrome with increased risk for bilateral vestibular schwannomas, intradermal schwannomas, meningiomas and less commonly ependymoma. SMARCB1-related SWN is a familial SWN-syndrome associated with peripheral and spinal schwannomas and an increased risk for meningiomas and malignant peripheral nerve sheath tumors, even in the absence of radiation. These individuals do not develop bilateral vestibular schwannomas. Finally, patients with LZTR1-related SWN typically present with peripheral schwannomas, and unilateral vestibular schwannomas have been reported. The following perspective is intended to highlight the clinical presentation and international tumor surveillance recommendations across these SWN-syndromes.
АНАЛІЗ РЕЗУЛЬТАТІВ АНТИБІОТИКОТЕРАПІЇ ОПІКОВОГО СЕПСИСУ В ДОРОСЛИХ
Authors: СУХОДОЛЯ А. І. , КРЕНЬОВ К. Ю. , ГРИНЧУК О. П. , ТЕРЕЩУК В. В. 
Published: February 2025

Мета роботи: провести аналіз частоти опікового сепсису та ефективності стартової антибіотикотерапії у дорослих пацієнтів.
Матеріали і методи. Проаналізовано карти стаціонарного хворого у пацієнтів відділення комбустіології КНП «Хмельницька обласна лікарня» протягом 2023–2024 рр., а також визначено збудники, час призначення та ефективність антибіотикотерапії.
Результати. Стартовим антибіотиком при госпіталізації пацієнтів у відділення були цефалоспорини ІV покоління, які комбінували із аміноглікозидами. Надалі після отримання попередніх результатів бактеріологічного дослідження проведено корекцію режимів антибактеріальної терапії та контроль за рівнями прокальцитоніну. Всього було виділено 48 ізолятів, з яких 22 склали Acinetobacter baumanii, 9 – Klebsiela pneumoniae, 6 – Pseudomonas aeruginosa, 6 – Streptococcus spp., 4 – Corinebacterium spp., 1 – Enterococcus faecalis. Чутливість зазначених патогенів суттєво змінилася протягом років, оскільки відбувається селекція стійких штамів. У 14 випадках пацієнтам призначено комбінацію препаратів «Меропенем» та «Ванкоміцин», 8-м хворим – «Піперацилін»/«Тазобактам» та «Тобраміцин», 6-м – «Азтреонам» та «Тобраміцин» і 2-м – заміну антибіотикотерапії не проводили: «Цефтазидим» та «Амікацин» і «Цефоперазон»/«Сульбактам» та «Амікацин». Переглядами схему антибіотикотерапії через 48 год та в подальшому після стабілізації стану проводили деескалацію. В результаті лікування летальність у групах становила: «Меропенем» та «Ванкоміцин» – 3 пацієнти (10 %), «Піперацилін»/«Тазобактам» і «Тобраміцин» – 3 хворих (10 %), «Азтреонам» та «Тобраміцин» – 1 пацієнт (3,3 %) при загальній летальності в описаних групах (23,33 %).
Висновки. Моніторинг «мікробного пейзажу» у відділеннях комбустіології вказує на значну наявність мікроорганізмів групи ESCAPE в 77,1 % та зниження чутливості ізолятів до основних груп антибактеріальних препаратів протягом 2021–2023 рр. високим представленням полірезистентних штамів Acinetobacter baumanii – у 18,48 %, Klebsiela pneumoniae – в 11,5 %, Pseudomonas aeruginosa – у 9,6 % випадків.
Epidemiology of Maternal Hypertensive Disorders
Authors: Zhao Yan , Wang Yue , Tong Fei , Gao Qianqian , Li Baoxuan 
Published: February 2025

BACKGROUND:
Maternal hypertensive disorders during pregnancy are a worldwide health problem, particularly in the countries/regions with low sociodemographic levels. This study aimed to reveal and predict the hypertensive disorders during pregnancy-related epidemiological trends.

METHODS:
Using data from the Global Burden of Disease 2019 study, we constructed an age-period-cohort model to assess the net drift (annual percentage changes), associated age, period, and cohort effects across global and different sociodemographic index (SDI) regions. Moreover, we analyzed attributable risk factors and future trends based on the autoregressive integrated moving average model.

RESULTS:
The numbers of hypertensive disorders during pregnancy worldwide increased by 10.9% (95% uncertainty interval, 6.1–15.3) from 1990 to 2019 and only increased in the low-SDI countries. The age-standardized incidence rate declined by 23.6% (20.6, 26.9), with a global net drift of −0.8%, whereas some higher-SDI countries showed a positive net drift. After controlling for period and cohort factors, the highest incidence was observed in the 20- to 29-year age group. The period and cohort effects showed decreasing trends, whereas unfavorable period effects occurred after 2010 in high-SDI and middle-high-SDI countries. High-income North America and western sub-Saharan Africa have shown increased numbers of disability-adjusted life years due to malnutrition. The autoregressive integrated moving average model revealed downward trends in the global incidence and age-standardized incidence rate by 2030.

CONCLUSIONS:
Our study highlights significant regional and national variations and age differences in the burden of hypertensive disorders during pregnancy associated with SDI stratification, which will facilitate the targeting of cost-effective health policy planning, resource allocation, and women’s health management by policymakers.
Aspirin Improves Uterine Artery Function in Hypercholesterolemic Preeclampsia
Authors: de Oliveira Amanda A. , Spaans Floor , Graton Murilo E. , Stokes Angie , Kirschenman Raven , Quon Anita , Cooke Christy-Lynn M. , Davidge Sandra T. 
Published: February 2025

BACKGROUND:
Excessive hypercholesterolemia in pregnancy increases the risk of preeclampsia, though the mechanisms remain unclear. We recently showed that uterine artery function is impaired in hypercholesterolemia-preeclampsia via activation of the TLR4 (toll-like receptor 4)/PGHS1 (prostaglandin H synthase 1) pathway. Low-dose aspirin lowers preeclampsia risk in high-risk pregnancies by inhibiting PGHS1, but its effects in hypercholesterolemia-preeclampsia pregnancies are not known. Moreover, oxidized low-density lipoprotein levels rise in hypercholesterolemia-preeclampsia, potentially activating TLR4 and LOX-1 (lectin-like oxLDL receptor-1; scavenger receptor linked to vascular dysfunction in preeclampsia). However, whether this occurs in hypercholesterolemia-preeclampsia is not known.

METHODS:
Sprague Dawley rats received a control or high-cholesterol diet (to induce hypercholesterolemia-preeclampsia) from gestational day 6 to 20, with placebo or low-dose aspirin (1.5 mg/daily) given from gestational day 10 to 20. On gestational day 20, pregnancy outcomes and uterine artery function were assessed.

RESULTS:
Uterine artery blood flow velocity and placental weights were higher in hypercholesterolemia-preeclampsia placebo-treated dams versus controls, but these were reduced by low-dose aspirin. Endothelium-dependent vasodilation was impaired in the uterine arteries of the hypercholesterolemia-preeclampsia placebo group versus controls and was corrected by low-dose aspirin. Ex vivo inhibition of TLR4, PGHS1, or LOX-1 also normalized endothelium-dependent vasodilation in the hypercholesterolemia-preeclampsia placebo-treated dams. Exposure to oxidized low-density lipoprotein in the bath (modeling a secondary hit) further impaired endothelium-dependent vasodilation in the uterine arteries of the hypercholesterolemia-preeclampsia placebo group, partially via TLR4 and LOX-1, which was prevented by low-dose aspirin.

CONCLUSIONS:
Low-dose aspirin improved uterine artery endothelial function in hypercholesterolemia-preeclampsia pregnancies; likely by suppressing the TLR4/LOX-1/PGHS1 pathway.
Osiemnastowieczny litewski przekład książki „Historya bardzo piękna” autorstwa Kiprijonasa Lukauskasa
Authors: Pajėdienė Jūratė 
Published: February 2025

Kiprijonas Lukauskas’s Eighteenth-Century Lithuanian Translation of Historya bardzo piękna
This article compares two groups of texts included in a collection of manuscripts by Kiprijonas Lukauskas (1797) with their Polish original. The texts in question are Historia łabay grazi [The Great Story] and Priedotkas isz Knigu Mundribes Jezusa Sunaus Syrach, kuri wadinam Ecclesiasticus [Appendix from the Book of Wisdom of Jesus the Son of Sirach, called Ecclesiasticus]. The original is an anonymously published eighteenth-century book which is considered to be a later version of Historya barzo cudna [The Marvellous Story] by Krzysztof Pussman (1551). The book contains the apocryphal biblical story Historya bardzo piękna [The Great Story] and a collection of biblical proverbs: Przydatek z Ksiąg Mądrości Jezusa, syna Syrachowego, ktore zowią Ecclesiasticus [Appendix from…]. The analysis indicates that Lukauskas’s translation is closest to the fourth eighteenth-century edition of this book.

Osiemnastowieczny litewski przekład książki Historya bardzo piękna autorstwa Kiprijonasa Lukauskasa
W artykule porównano dwie grupy tekstów – Historia łabay grazi oraz Priedotkas isz Knigu Mundribes Jezusa Sunaus Syrach, kuri wadinam Ecclesiasticus, które znalazły się w zbiorze rękopisów Kiprijonasa Lukauskasa (Cypriana Łukawskiego) z 1797 roku – z polskim oryginałem, którym jest wydana w XVIII wieku anonimowa książka będąca kolejną wersją Historii barzo cudnej (1551) Krzysztofa Pussmana. Książka zawiera apokryficzną opowieść biblijną Historya bardzo piękna oraz zbiór przysłów biblijnych Przydatek z Ksiąg Mądrości Jezusa, syna Syrachowego, ktore zowią Ecclesiasticus. Z przeprowadzonej analizy wynika, że przekład Lukauskasa jest najbardziej zbliżony do czwartego osiemnastowiecznego wydania tej książki.
Meta-analysis of EGFR gene polymorphisms and lung cancer risk
Authors: Fakhkhari Meryem , Salih Ikram , Errafii Khaoula , Hamdi Salsabil , Sadki Khalid 
Published: February 2025

Objective: This meta-analysis aims to systematically evaluate the associations of four specific Single Nucleotide Polymorphisms (SNPs)—rs712829, rs712830, rs11568315, and rs884225—located in the promoter, intronic, and 3’ untranslated regions (3’UTR) of the EGFR gene, with lung cancer risk. Introduction: The associations between EGFR gene polymorphisms and lung cancer risk is a topic of ongoing debate, which is still deemed controversial. Despite numerous studies, results are inconsistent. Methods: We conducted a comprehensive literature search across the PubMed, Science Direct, and Web of Science databases to identify relevant case-control studies examining the association between EGFR gene polymorphisms and lung cancer risk. Results: From an initial pool of 26,959 articles, 10 case-control studies were included, involving 2471 lung cancer patients and 4489 controls. A significant association between rs712829 and increased lung cancer risk was found across multiple genetic models. Under the allelic contrast model (G vs T), the OR was 1.31 (95% CI = [1.02; 1.68], p < 0.05), the dominant model (GG + GT vs TT) showed an OR of 1.69 (95% CI = [1.07; 2.67], p < 0.05), the homozygote model (GG vs TT) yielded an OR of 1.70 (95% CI = [1.00; 2.88], p < 0.05), and the heterozygote model (GT vs TT) had an OR of 1.64 (95% CI = [1.01; 2.66], p < 0.05). No significant associations were found for rs11568315, rs712830, and rs884225. Conclusion: The findings from the current meta-analysis confirm that rs712829 within the EGFR gene is significantly associated with lung cancer risk according to the allele, dominant, homozygote and heterozygote models.
Melatonin alleviates oral epithelial cell inflammation via Keap1/Nrf2 signaling
Authors: Zhang Nan , Wang Wenjing , Zhang Rongxia , Liu Yaxuan , Wang Yamei , Bai Yang , Li Chencong 
Published: February 2025

Background: Oral mucosal diseases manifest primarily as inflammatory conditions. These diseases affect approximately half a billion people worldwide. Objective: Novel and effective strategies for treating inflammatory diseases of the oral mucosa have great potential for improving patient outcomes, and warrant study. Methods: The impact of melatonin on inflammation was investigated using RAW264.7 macrophages and HOEC and HSC-3 oral epithelial cells. Results: Melatonin decreased macrophage-induced inflammation by acting through the melatonin receptor MTNR1A. Additionally, melatonin mitigated macrophage-induced inflammation in oral epithelial cells. Importantly, the results demonstrated that the effects of melatonin on oral epithelial inflammation were mediated through the KEAP1/Nrf2 signaling pathway. Conclusion: These findings will contribute to the development of innovative therapies for inflammatory conditions affecting the oral epithelium.
Exploring the use of mindfulness for prevention of burnout in allied health professionals in Singapore
Authors: Yap Shun Hwa , Zainal Liyana Nabilah Bte , Yusoff Siti Zubaidah Binte , Tan Xiang Ren 
Published: February 2025

Background Burnout is becoming increasingly prevalent among healthcare professionals where it impacts quality of care and staff turnover, especially in the wake of the COVID-19 pandemic. One promising strategy to reduce burnout is the use of mindfulness-based programs, which may aid allied health professionals (AHPs). Objective To explore the usefulness of a 10-week mindfulness program on reducing burnout symptoms in AHPs in Singapore, as well as to identify AHPs’ attitudes and perceptions towards adopting mindfulness in practice. Methods In this mixed methods study, a purposive sample (n = 8) of physiotherapists, occupational therapists, and therapy assistants were recruited. Participants underwent a mindfulness program, comprising 5 face-to-face sessions every other week for 10 weeks. Quantitative data were collected at pre- and post-intervention stages using a survey on participant characteristics and the Maslach Burnout Inventory – Human Services Survey for Medical Personnel to assess burnout symptoms. Qualitative data were collected through semi-structured interviews. Results There was a decrease in emotional exhaustion scores (34.50 to 25.50, p = 0.012) while depersonalization (p = 0.107) and personal accomplishment (p = 0.062) scores showed no significant changes. Qualitative benefits reported include increased introspection, improved emotional regulation and communication, and fostering of supportive workplace culture. Advocacy from superiors and the perceived effectiveness of mindfulness techniques can facilitate the adoption of the mindfulness program. Conclusion A 10-week mindfulness program reduced burnout symptoms, specifically emotional exhaustion, among AHPs. Future studies should explore the application of the program within a larger participant sample to develop an optimal model for feasible and pragmatic adoption within the clinical setting.
Effect of proprioceptive neuromuscular facilitation and focal vibration in older adults with osteoarthritis after total knee arthroplasty: A randomized clinical trial study
Authors: Markopoulos Nikolaos , Apostolou Thomas , Kallistratos Ilias , Lytras Dimitrios , Iakovidis Paris 
Published: February 2025

Background Postoperative balance disorders in older adults after total knee arthroplasty (TKA) due to osteoarthritis are commonly attributed to proprioceptive joint deficits. Both Proprioceptive Neuromuscular Facilitation (PNF) and Focal Vibration (FV) can improve balance and proprioception. Aim To examine the combination of a PNF exercise program and quadriceps tendon FV in older adults after TKA due to osteoarthritis. Methods Ninety older adults who underwent TKA were randomly assigned to three groups of 30. The PNF Group followed a 6-week PNF exercise program starting four weeks post-surgery. The PNF + FV Group followed the same PNF program combined with FV applied to the rectus femoris and vastus medialis. The control group received instructions for a home-based exercise program. Pain (Numeric Pain Rating Scale; NPRS), knee range of motion (ROM), functional ability (Knee Injury and Osteoarthritis Outcome Score, KOOS), joint position sense (JPS), postural sway (force platform), and balance (Timed Up-and-Go; TUG test, Berg Balance Scale; BBS) were evaluated at baseline, six weeks, and six months post-intervention. A two-way repeated measures ANOVA analysis was applied with significance set at p < .05. Results The PNF + FV group showed significant improvements compared to the control group in NPRS, KOOS, TUG, BBS, displacement parameters, and absolute error scores (p < .05). The PNF + FV group showed earlier improvements compared to the PNF group, indicating faster adjustments due to the combined effect of PNF and FV. Additionally, the PNF + FV group showed greater improvement in TUG, BBS, KOOS sport, anterior-posterior displacement distance, and absolute error scores at 25° compared to the PNF group (p < .05). PNF exercises improved knee ROM (p < .05) with no additional effect from FV. Conclusions A 6-week protocol combining PNF exercises and FV significantly improved balance, knee joint position sense, knee functional ability, and pain intensity in older adults after TKA due to osteoarthritis. These findings suggest faster and more effective rehabilitation, potentially reducing postoperative disorders and future injury risks. Further research is needed to investigate the combination of FV and PNF.
Biomechanical characteristics and neuromuscular action control mechanism of single-dual-task walking-conversion training in stroke patients
Authors: Sheng Yilan , Han Jia 
Published: February 2025

Background and purpose This study aimed to explore the biomechanical characteristics of patients with stroke and neuromuscular action control mechanisms in single-dual-task walking-conversion training. Materials and methods Patients with stroke from four centers were enrolled and randomly divided into the cognitive combined treadmill-walking and exercise combined treadmill-walking groups (n = 30 per group). The gait spatiotemporal parameters, walking function, and fall risk of the two experimental groups were compared before and after 4 and 6 weeks of training. Surface electromyography (sEMG) and functional near-infrared spectroscopy (fNIRS) were performed to analyze neuromuscular action control mechanisms in different task phases. Results After 6 weeks of training, the gait spatiotemporal parameters, walking function, integral electromyogram (iEMG) values, and root mean square (RMS) of the affected lower limb muscles of the two experimental groups significantly improved ( P < 0.01), while the fall risk was reduced ( P < 0.01). fNIRS analysis showed that in both the single- and dual-task phases, HbO signal concentrations in the brain functional regions of the two experimental groups significantly increased after training ( P < 0.01). These indicators were not significantly different between the two experimental groups after 6 weeks of training ( P > 0.05). In addition, during the dual-task phase, the blood oxygen signal concentrations and functional connectivity in the functional brain regions of the two experimental groups were lower than those of healthy controls. Conclusion Cognitive or motor tasks combined with treadmill-walking training can promote the recovery of physical function in patients with stroke. Clinical trial registration: This study was registered in the Chinese Clinical Trial Registry (ChiCTR; registration number: ChiCTR2200060864).
Return to school after adolescent idiopathic scoliosis (AIS) posterior spinal fusion: Establishing a baseline in Saudi Arabia
Authors: Addar Abdullah , Al-Qarni Nizar , Alaqeel Musab , Addweesh Abdurahman Khalid , Alkhateb Munib Nader , Alsiddiky Abdulmonem 
Published: February 2025

Introduction Return to school (RTS) after adolescent idiopathic (AIS) scoliosis surgery is a critical outcome measure signifying a return to everyday life. Prior studies in Western populations report an average RTS of 42.3 days for AIS surgery. This study aims to estimate RTS and identify factors affecting it in Saudi Arabia. Method This retrospective cross-sectional study included 48 AIS patients who underwent posterior spinal fusion (PSF). Data collected included demographics, surgical details, and recovery timelines. After identifying the average time to return to school, patients were categorized based on RTS duration, with a 42-day cutoff. Factors that could delay the time to return to school were analyzed. Result Among the 48 patients, 41 (85.4%) were female, with a mean age of 14.47 years (SD 2.7). The average RTS was 60.1 days (SD 24). Significant associations were found between RTS and age at surgery (12.92 years for RTS ≤ 42 days vs 14.84 years for RTS > 42 days, p = 0.04) and levels fused (15.40 for RTS ≤ 42 days vs 13.38 for RTS > 42 days, p = 0.036). Other factors showed no significant associations. Conclusion The average RTS after scoliosis correction in Saudi Arabia is two weeks longer than the average in other countries. Further studies are needed to develop solutions to reduce the delayed RTS in Saudi Arabia.
The Effect of Residential Distance from Inpatient Setting on Outcomes of Rehabilitation Following Acquired Brain Injury
Authors: Bradley Lloyd 
Published: February 2025

Backgound Inpatient rehabilitation may be required after an acquired brain injury. This can be located a long way from someone's usual residence. Outcomes for those living further away from the inpatient setting could be impacted by the complexities of discharge planning and limited access to family and friends. Objective To determine the relationship between distance of usual residence from the location of inpatient rehabilitation and subsequent rehabilitation outcomes. Methods A retrospective cohort analysis of patients admitted between 2014 and 2022 to a neurorehabilitation unit comparing admission complexity, diagnostic category, wait for admission, length of stay, change in functional status and care needs between patients usually resident near (< 20 miles) and distant (>=20 miles) from the unit. Results For the 849 patients admitted there were no differences between the groups in the time since initial injury (p = .99), baseline complexity (p = .51), functional status (p = .31), care needs (p = .78) nor in the different diagnostic categories. There were no differences in their length of stay (p = .20), change in their functional status (p = .69) or care needs (p = .68). Conclusions The provision of appropriate facilities is more important to patient outcomes than geographical proximity for inpatient rehabilitation following acquired brain injury.
Torpedo maculopathy in a patient with DeSanto-Shinawi syndrome
Authors: Petroni Sergio , Catena Gino , Iarossi Giancarlo , Federici Matteo , Zinzanella Gaetano , De Sanctis Carlo Maria , Valente Paola , Buzzonetti Luca 
Published: February 2025

Introduction Torpedo maculopathy (TM) is a rare, typically benign and congenital anomaly of the retinal pigment epithelium (RPE) characterized by a torpedo-shaped lesion in the macula. DeSanto-Shinawi syndrome (DESS) is an equally rare genetic disorder caused by mutations in the WAC gene, presenting with intellectual disability, dysmorphic features, and growth retardation. Case description This report illustrates the case of monolateral TM in a patient with DESS. The genetic and phenotypic characteristic were described and correlated with retinal features, assessed by means of retinography, spectral domain OCT (SD-OCT) and fluorescein angiography (FA). Conclusion This case report discusses the unusual co-occurrence of TM in a patient diagnosed with DESS, contributing to the sparse literature on this association and expanding the phenotypic spectrum of both conditions.