bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nature’s Guidance: Employing Bio-inspired Algorithm and Data-Driven Model for Simulating Monthly Maximum and Average Temperature Time Series in the Middle Black Sea Region of Türkiye
Authors: Katipoğlu Okan Mert , Terzioğlu Zeynep Özge , Zerouali Bilel 
Published: February 2025

Abstract
This study compares the performance of various models in predicting monthly maximum and average temperatures across three distinct regions: Samsun, Amasya, and Çorum. The evaluated models include Artificial Neural Network (ANN), Shuffled Frog Leaping Algorithm coupled with ANN (SFLA-ANN), Firefly Algorithm coupled with ANN (FFA-ANN), and Genetic Algorithm coupled with ANN (GA-ANN). In setting up the models, the dataset was divided into 70% for training and 30% for testing, and the outputs of the models were evaluated using various graphical and statistical indicators. The model with the smallest root mean square error (RMSE) value was selected for the maximum and average temperature predictions. Accordingly, for maximum and average temperature predictions, SFLA-ANN (RMSE of 2.93) and GA-ANN (RMSE of 3.55) in Samsun, GA-ANN (RMSE of 2.91) and GA-ANN (RMSE of 2.50) in Amasya and GA-ANN (RMSE of 2.97) and GA-ANN (RMSE of 2.50) in Çorum performed better than the other models, respectively. In addition, for the maximum temperature prediction with the highest accuracy, the R2 value of the SFLA-ANN model in Samsun was 0.89. In contrast, the R2 values of the GA-ANN model in Amasya and Çorum were determined as 0.91 and 0.91, respectively. Similarly, it was observed that the R2 values of the GA-ANN model for the average temperature prediction with the highest accuracy at Samsun, Amasya and Çorum stations were 0.78, 0.92 and 0.92, respectively. Overall, the GA-ANN consistently demonstrated superior performance in predicting both maximum and average temperatures across all three regions, as evidenced by its consistently low RMSE values. These findings provide valuable insights into selecting effective models for temperature prediction tasks in different geographical regions.
Exploring the role of psychological flexibility in relationship functioning among couples coping with prostate cancer: a cross-sectional study
Authors: Ma Hongen , Cariola Laura , Gillanders David 
Published: February 2025

Abstract

Objective
Prostate cancer (PCa) is an external stressor that can affect both patients and partners, but dyadic research in this area is limited. This study, guided by the vulnerability-stress-adaptation model, examines how PCa distress affects relationship satisfaction through psychological flexibility and self-esteem.

Methods
The study used a cross-sectional design with a total sample size of 314 dyads. The actor-partner interdependence model was applied to examine both actor and partner effects. Covariates were also examined.

Results
PCa distress negatively predicted psychological flexibility in both patients (

$$\beta$$

β

= − .93, p < .001) and partners (

$$\beta$$

β

= − 0.70, p < .001). Psychological flexibility, in turn, positively predicted self-esteem in both patients (

$$\beta$$

β

= 0.19, p < .001) and partners (

$$\beta$$

β

= 0.19, p < .001). Self-esteem significantly predicted relationship satisfaction for both patients (

$$\beta$$

β

= 0.22, p < .001) and partners (

$$\beta$$

β

= 0.22, p < .001). The indirect effects of PCa distress on relationship satisfaction via psychological flexibility and self-esteem were significant for both patients (

$$\beta$$

β

= − .093, p < .001) and partners (

$$\beta$$

β

= − .078, p < .001). Additionally, a significant indirect effect of partners’ PCa distress on patients’ relationship satisfaction was observed (

$$\beta$$

β

= − .055, p < .01).

Conclusion
The findings highlight the critical role of psychological flexibility and self-esteem in mediating the impact of PCa distress on relationship satisfaction for both patients and partners. Tailored interventions aimed at enhancing psychological flexibility to support relationship functioning in couples coping with PCa may be effective.
A generic seismic risk protocol for energy production sites
Authors: Grigoratos Iason , Schultz Ryan , van Ginkel Janneke , Gunatilake Thanushika , Wiemer Stefan , van der Wal Jorien L.N. , Muntendam-Bos Annemarie G. 
Published: February 2025

Abstract
Activities related to energy production have been linked with felt (and in some cases damaging) earthquakes. Notable examples include hydraulic fracturing, wastewater disposal, geothermal systems, coal mining, carbon storage and hydropower dams. As the demand for energy continues to grow, new frontiers in energy exploration will emerge - some with the potential for induced seismicity. Thus, there is a clear need for a source-agnostic seismic risk protocol that can be applied to any activity or region. This study outlines one such implementation that uses scenario earthquakes to produce a priori risk thresholds that can be referenced against current seismicity levels on an ongoing basis. Our framework is designed to inform regulatory decisions by considering the consequences of earthquake scenarios on the population and the built environment, together with simplified forecasts of the next largest magnitude. The proposed framework can tackle both the screening process needed for permitting purposes and serve as a risk management plan during operations.
Co-occurring Early Adolescent ACEs and Associations With Later Peer Relationships
Authors: Wang Joy Huanhuan , Merrin Gabriel J. , Wang Xiafei , Liu Qingyang , Kiefer Sarah M. 
Published: February 2025

Abstract
Research indicates complex associations between adverse childhood experiences (ACEs) and adolescent peer relationships. ACEs are related to lower peer status, yet the links between ACEs, peer characteristics, and peer relationship quality are inconclusive. The current literature has several further conceptual and methodological limitations, including a lack of attention to ACEs’ co-occurring nature, the developmental timing of ACEs during adolescence, and the multifaceted nature of peer relationships. In addition, much of the literature is cross-sectional. The current study addresses these limitations by examining the associations of early adolescents’ co-occurring ACEs at age 12 with three subsequent peer relationship aspects at age 16 (i.e., peer characteristics, peer status, and peer relationship quality) while controlling for demographics and early adversities. Participants included 883 youth from the Longitudinal Studies of Child Abuse and Neglect. Latent class analyses of the 10 ACEs, as examined in the original CDC-Kaiser ACE study, identified three distinct ACE classes at age 12 (threat, deprivation, and low ACEs) that were distinguished by gender, race, income, and early adversities. Further, the threat class was related to adverse outcomes in peer characteristics and status, while the deprivation class was associated with differences in peer relationship quality. These findings highlight the need for researchers and practitioners to consider ACEs’ co-occurring nature and tailor trauma-informed care accordingly. Findings also underscore the salience of studying ACEs that occur in the developmental period of early adolescence.
Interstitial Cystitis/Bladder Pain Syndrome: Matching Therapies to the Patient
Authors: Moldwin Jennifer Fariello , Moldwin Robert M. 
Published: February 2025

Abstract

Purpose of Review
We intend to establish broad clinical subgroups of patients and match them to a more tailored approach with improved clinical outcomes.

Recent Findings
Patient experience over the past four decades and investigative initiatives such as The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) have led to the development of four broad categories of IC/BPS patients: bladder-centric (which is further sub-divided into those with Hunner lesion disease (HLD) and those without (IC/BPS)); widespread/centralized pain; and myofascial pelvic floor tenderness. Other systems of patient categorization, such as UPOINT, now INPUT, highlight the complexities of patient assessment.
Reanalysis of previous failed clinical trials and common sense suggests that matching the therapy's mechanism of action to the patient’s phenotype may yield better therapeutic outcomes.

Summary
Although the IC/BPS population is known to be phenotypically heterogeneous, therapeutic approaches afforded by most current guidelines have been relatively rigid, only accounting for those patients with and without Hunner lesions. Segregating the IC/BPS population further into distinct phenotypic groups that may respond to targeted therapy is relatively simplistic but represents an essential first step toward precision care.
Differential scanning fluorimetry followed by microscale thermophoresis and/or isothermal titration calorimetry as an efficient tool for ligand screening
Authors: Winiewska-Szajewska Maria , Poznański Jarosław 
Published: February 2025

Abstract
Various biophysical and biochemical techniques have been developed to measure the affinity of interacting molecules. This review analyzes the combination of three methods: differential scanning fluorimetry as the initial high-throughput screening technique and microscale thermophoresis and isothermal titration calorimetry as complementary methods to quantify binding affinity. The presented work is the first to detailed compare the strengths and flaws of these three specific methods, as well as their application possibilities and complementarity. The fundamentals of these methods will be covered, including the most often-used models for characterizing observable phenomena and an emphasis on methods for analyzing data. A comprehensive review of numerous approaches to data analysis found in the literature is additionally provided, with the benefits and drawbacks of each, as well as the pitfalls and related concerns. Finally, examples of different systems will be presented, and methods used and some discrepancies in results will be described and discussed.
Influence of Electron Drift Velocity on Ion-Acoustic Solitary Waves in Collisionless Electron–Positron-Ion Plasmas
Authors: Das Ranjan , Madhukalya Bhargab , Hosseini Kamyar , Alizadeh Farzaneh , Baleanu Dumitru 
Published: February 2025

Abstract
This study explores the complex behavior of ion-acoustic (IA) solitary waves (SWs) in unmagnetized collisionless plasmas composed of electrons, thermal positrons, and positive ions, with particular attention to the influence of electron drift velocity. By employing a fluid model and the reductive perturbation method (RPM), we retrieve the Korteweg-de Vries (KdV) equation, which describes the weakly nonlinear progression of such waves. The findings show the presence of two distinct IA modes, i.e., fast and slow. In the fast mode, KdV solitons occur within two different ranges of drift velocities (

$$0<{{v}_{e}^{\prime}}\le 172$$

0
<

v

e

′

≤
172

and

$${{v}_{e}^{\prime}}\ge 199$$

v

e

′

≥
199

), whereas for the slow mode, solitons appear when

$${{v}_{e}^{\prime}}\ge 223$$

v

e

′

≥
223

. Numerical simulations indicate that the fast mode supports both compressive and rarefactive solitons, while the slow mode only supports compressive solitons. The study underscores the importance of distinct factors such as positron density

$$\left(\mu \right)$$

μ

, electron drift velocity

$$\left({v}_{e}^{\prime}\right)$$

v

e

′

, and temperature ratios of electron to positron

$$\left(\delta \right)$$

δ

in determining the properties of solitons. The results offer valuable insights into space plasmas where similar plasma compositions and drift velocities can affect the transmission of IA waves in planetary ionospheres and interstellar spaces.
Aura Ozone Monitoring Instrument (OMI) Collection 4 Formaldehyde Products
Authors: Ayazpour Zolal , González Abad Gonzalo , Nowlan Caroline R. , Sun Kang , Kwon Hyeong‐Ahn , Chan Miller Christopher , Chong Heesung , Wang Huiqun , Liu Xiong , Chance Kelly , O’Sullivan Ewan , Zhu Lei , Vigouroux Corinne , De Smedt Isabelle , Stremme Wolfgang , Hannigan James W. , Notholt Justus , Sun Xiaoyu , Palm Mathias , Petri Cristof , Strong Kimberly , Röhling Amelie N. , Mahieu Emmanuel , Smale Dan , Té Yao , Morino Isamu , Murata Isao , Nagahama Tomoo , Kivi Rigel , Makarova Maria , Jones Nicholas , Sussmann Ralf , Zhou Minqiang 
Published: February 2025

AbstractThis study presents the ozone monitoring instrument (OMI) Collection 4 formaldehyde (HCHO) retrieval developed with the Smithsonian Astrophysical Observatory's (SAO) Making Earth System Data Records for Use in Research Environments (MEaSUREs) algorithm. The retrieval algorithm updates and makes improvements to the NASA operational OMI HCHO (OMI Collection 3 HCHO) algorithm, and has been transitioned to use OMI Collection 4 Level‐1B radiances. This paper describes the updated retrieval algorithm and compares Collection 3 and Collection 4 data products. The OMI Collection 4 HCHO exhibits remarkably improved stability over time in comparison to the OMI Collection 3 HCHO product, with better precision and the elimination of artificial trends present in the Collection 3 during the later years of the mission. We validate the OMI Collection 4 HCHO data product using Fourier‐Transform Infrared (FTIR) ground‐based HCHO measurements. The climatological monthly averaged OMI Collection 4 HCHO vertical column densities (VCDs) agree well with the FTIR VCDs, with a correlation coefficient of 0.83, root‐mean‐square error (RMSE) of molecules , regression slope of 0.79, and intercept of molecules . Additionally, we compare the monthly averaged OMI Collection 4 HCHO VCDs to OMPS Suomi NPP, OMPS NOAA‐20, and TROPOMI HCHO VCDs in overlapping years for 12 geographic regions. This comparison demonstrates high correlation coefficients of 0.98 (OMPS Suomi NPP), 0.97 (OMPS NOAA‐20), and 0.90 (TROPOMI).
Leveraging INSAT‐3D Indian Geostationary Satellite for Advanced Lightning Detection and Analysis
Authors: Goenka Rounaq , Taori Alok , Rao G. Srinivasa , Chauhan Prakash 
Published: February 2025

AbstractAtmospheric lightning is an outcome of interplay among the meteorological parameters under the influence of convective processes occurring in troposphere. Radiation, temperature, and wind are the prime driving parameters of the convective phenomena. Often, the reanalysis data has been utilized to understand the precursors of lightning occurrences. As the lightning is a disaster where nowcasting is important, for operational utilization, it is deemed to utilize space‐borne near real‐time measurements. The present study investigates the utilization of near real‐time Indian remote sensing geostationary satellite (viz., INSAT) products (outgoing longwave radiation, land surface temperature, and winds) to identify the precursory signatures of the lightning occurrences. Results reveal that a lead‐time of about 2.5 hr can be achieved with agreement ranging from 0.6 to 0.8. The study provides first step into the prediction of the lightning occurrences over India using the Indian remote sensing geostationary satellite.
Inefficient Loss of Moderately Volatile Elements From Exposed Planetesimal Magma Oceans
Authors: Zhang Zhongtian , Driscoll Peter E. 
Published: February 2025

AbstractSome melted and differentiated planetesimals, such as the parent bodies of angrites and howardite‐eucrite‐diogenite meteorites, are severely depleted in moderately volatile elements (MVEs). The origins of these depletions are critical for understanding early solar system evolution but remain topics of debate. Numerous previous studies have invoked evaporation from magma oceans as a potential mechanism for producing these depletions, yet this process is poorly explored. In this study, we examine the efficiency of MVE loss from planetesimal magma oceans. Upon heating from short‐lived , internal magma oceans can develop beneath insulating crusts. The magma oceans may be exposed to the surface by collisional disruption of the crusts, but would be rapidly cooled by the cold environments. The exposed surface would be quenched to solid/glass; even if the quenched skin can be recycled by convection such that the magma ocean can be continuously resurfaced, only a small portion of the surface can remain molten. In the convection boundary layer, “vertical” advection is suppressed, energy and element transports toward the surface occur via thermal and chemical diffusion (if MVEs do not exsolve as bubbles). As chemical diffusivity is much smaller than thermal diffusivity, MVE transport is much less efficient than heat transport, and MVE loss during magma ocean cooling is likely minimal ( the total inventory). Therefore, MVE depletions may not be easily explained by evaporation from ‐heated planetesimal magma oceans.
CircFUNDC1 interacts with CDK9 to promote mitophagy in nucleus pulposus cells under oxidative stress and ameliorates intervertebral disc degeneration
Authors: Gu Tianyuan , He Yong , Zhou Jianan , Qiu Xiaoming , Yang Wentao , Zhu Qiong , Liang Yi , Zheng Yang , Yik Jasper H. N. , Haudenschild Dominik R. , Fan Shunwu , Liu Chao , Shi Wenli , Yao Shasha , Ni Weiyu , Hu Ziang 
Published: February 2025

Abstract
Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding of disease mechanisms. In this study, we report that circFUNDC1, a nuclear circular RNA, is markedly downregulated in nucleus pulposus cells (NPCs) from patients with end-stage IVDD. CircFUNDC1 is derived from the gene encoding the FUN14 domain-containing 1 (FUNDC1) protein, which is essential for mitophagy and cell survival. Functional analyses reveal that circFUNDC1 plays a crucial role in maintaining extracellular matrix homeostasis by enhancing the expression of anabolic factors in NPCs. Additionally, we identified the transcriptional regulator cyclin-dependent kinase 9 (CDK9) as a novel binding partner for circFUNDC1. Binding with circFUNDC1 recruits CDK9 via complementary nucleotides to the FUNDC1 promoter to stimulate the production of full-length FUNDC1 mRNAs and proteins, forming a positive feedback loop. Overexpression of circFUNDC1 protects NPCs from oxidative stress by promoting mitophagy, reducing reactive oxygen species levels, and inhibiting cellular senescence. Moreover, circFUNDC1 overexpression delays the onset of IVDD in an ex-vivo culture model. This study is the first to demonstrate that circFUNDC1 is vital for protecting NPCs from oxidative stress, suggesting circFUNDC1 as a potential therapeutic target for IVDD.
The proteomic landscape of stool-derived extracellular vesicles in patients with pre-cancerous lesions and colorectal cancer
Authors: Northrop-Albrecht Emmalee J. , Kim Yohan , Taylor William R. , Majumder Shounak , Kisiel John B. , Lucien Fabrice 
Published: February 2025

Abstract
Colorectal cancer (CRC) is the 2nd most fatal cancer in the United States, but when detected early it is highly curable. Stool-derived extracellular vesicles (EVs) are a novel biomarker source that could augment the sensitivity for detection of CRC precursors. However, standardization of isolation methods for stool-derived EVs remains underexplored. We previously reported that size-exclusion chromatography (SEC) followed by ultrafiltration (UF-100kDa) was suitable for human stool supernatant EV isolation. In this study, we first assess alternative EV concentration methods (ultrafiltration [UF]; 10 kDa, 30 kDa, 50 kDa, 100 kDa and speed vacuum [SV]). Second, we investigate the host/bacterial EV proteomes by mass spectrometry. We report no difference in recovery, RNA and soluble protein contamination among concentration methods. Proteomic analysis reveals a diverse bacterial proteome, while human-derived proteins are more abundant. Specifically, pancreatic enzymes are among the most abundant proteins, further exploration revealed that zymogen granules are likely co-isolated in stool EV preparations. To enable discovery of EV-based molecular signatures of CRC precursors with high sensitivity, immunocapture strategies will likely be needed. Notably, we identified 10 surface proteins that may serve as candidates for the purification of colon-derived EVs. This work serves as framework for the future discovery and validation of EV-based biomarkers for CRC.
Room temperature amplified spontaneous emission in CsPbBr3 polycrystalline thin films in transmission configuration
Authors: Enea Nicoleta , Tommasi Federico , Forcieri Leonardo , Ion Valentin , Andrei Florin , Calisi Nicola , Falsini Naomi , Cavalieri Stefano , Vinattieri Anna 
Published: February 2025

We present an experimental study concerning the interplay between amplified spontaneous emission (ASE) and photoluminescence in polycrystalline thin films (100–300 nm) realized by Radio-Frequency Magnetron Sputtering (RF-MS) without the use of a waveguide configuration. Our results show that the amplification of the spontaneous emission requires only a thickness comparable to the absorption length (≈100 nm). Moreover, the strong ASE signal measured at room temperature shows a peculiar behavior performing a z-scan of the exciting beam waist: increasing the fluence, the decrease of the ASE intensity is accompanied by a significant decrease of the absorption coefficient, indicating the onset of a non-linear process due to multiexciton population (space filling effect) in the film nanocrystallites. Our studies performed with high spectral resolution reveal a modal structure with a significant stability in time, both in the spectral line shape and intensity, from pulse to pulse and demonstrate that CsPbBr3 nanometric films deposited by RF-MS can be efficiently used as active material for coherent light amplification. Moreover, the absorption change detected at high photon fluence can be used for the development of light modulators.
Readout electronics for neutron detectors at CSNS and CSNS-II: challenges, solutions, and progress
Authors: Liu H. , Bao X. , Cai D. , Chen S. , Guo H. , Jiang X. , Lai Y. , Li Q. , Li Y. , Luo H. , Ren J. , Sun Z. , Wang X. , Wang K. , Xiao L. , Xiu Q. , Yin W. , Yu L. , Zeng L. , Zhao Y. , Zhou J. 
Published: February 2025

Abstract
The China Spallation Neutron Source (CSNS), operational since 2018, is upgrading to CSNS-II, increasing the proton beam power to 500 kW and requiring advancements in detector technology and readout electronics. This paper summarizes the current state of readout electronics at CSNS and outlines the challenges posed by the CSNS-II upgrade, including higher neutron flux, vacuum operation requirements, and demands for higher spatial resolution. We present the development of low-power electronics suitable for vacuum environments, such as customized ASIC preamplifiers and digitization modules for 3He position-sensitive detectors. Additionally, we discuss the implementation of high-resolution Timepix4-based neutron cameras and high-density readout systems for 3He-GEM detectors. Preliminary results from demonstrator tests indicate that these solutions meet the stringent requirements of CSNS-II. These advancements will play a crucial role in the success of upcoming neutron instruments and significantly contribute to materials science research.