bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamics of Fluid Flow in Functionally Graded Tapered Pipes on Elastic Foundations
Authors: Rajasekaran Sundaramoorthy 
Published: April 2024

Abstract
Flow-induced vibration is a common phenomenon in fluid dynamics, finding applications from aeroelasticity to blood flow in arteries. This study presents a finite element formulation as well as Galerkn's method for analysing the free and forced vibration of pipes that carry either harmonically pulsating or uniform flows. Relevant finite element matrices and coefficients of Galerkin's method are derived to address dynamic and stability issues. Notably, the damping and stiffness matrices are shown to vary with time. Galerkin's approach is also employed to validate the results obtained through the finite element method. Furthermore, this research explores the dynamic and stable behaviour of pipes with various boundary conditions, such as simply supported, clamped, propped cantilever and cantilever pipes resting on elastic foundations. Additionally, it addresses the problems related to axially functionally graded tapered pipes conveying either Newtonian or non-Newtonian flows. The Connors critical velocity is also discussed as a measure of initiating fluid-induced instability. It is observed that the natural frequency and critical velocity increase with the flow index, Winkler foundation stiffness and mass ratio. Several numerical examples are provided to validate the applied methodologies. Overall, this research contributes valuable insights into the complex interactions between flow and vibration in various pipe configurations with practical implications across multiple engineering disciplines.
Transcriptomic profiling of the immune response to Siniperca chuatsi rhabdovirus (SCRV) in E11 cells
Authors: Zhang Yanbing , Sun Wei , Tan Xu , Gong Cuiping , Kong Weiguang , Liu Xiaodan 
Published: April 2024

Abstract
Siniperca chuatsi rhabdovirus (SCRV) has caused severe disease and mortality in commercial fish in China. To investigate the molecular relationships between pathogen and host, transcriptome analysis of SCRV-infected and non-infected E11 cells was obtained using the Illumina HiSeq X Ten sequencing system. There was 29,894 unigenes assembled and a total of 4137 differentially expressed genes (DEGs), consisting of 2189 up-regulated and 1948 down-regulated unigenes were detected between SCRV-infected and non-infected E11 cells. To understand the immune response of the virus in the host, pathway function analysis indicates that SCRV infection affected 31 typical immune-related pathways, including MAPK signaling pathway, PI3K-Akt signaling pathway, Endocytosis and Apoptosis, suggesting that E11 cells resist SCRV invasion through these innate immune pathways. Overall, qRT-PCR results showed similar expression to Illumina HiSeq, with reliable sequencing results. These results provided some vital clues which will be helpful to future study on SCRV-host interactions.
A 12-week randomized controlled trial of active mobilization of hamstring for non-specific low back pain and musculoskeletal discomfort during prolonged sitting among young people: Study protocol
Authors: Łabęcka Marta , Plandowska Magdalena , Truszczyńska-Baszak Aleksandra , Rajabi Reza , Płaszewski Maciej , Różańska Dorota 
Published: April 2024

Abstract
Introduction
This randomized controlled trial aims to investigate the effect of a 12-week intervention involving active hamstring flexibility exercises with hip flexion mobilization on reducing low back pain (LBP) and perceived musculoskeletal discomfort during prolonged sitting in young adults.
Methods
Participants were recruited from Physical Education Faculty students and randomly assigned to either the experimental group (hamstring flexibility exercises) or the control group (no intervention). The primary outcome measures will be average pain intensity, functional disability, and perceived musculoskeletal discomfort during prolonged sitting. Secondary outcome measures will be satisfaction with the intervention and flexibility of the hamstring.
Results
A total of 44 participants will fulfill the inclusion criteria and will be completed the study. The results will demonstrate changes in average pain intensity, functional disability, perceived musculoskeletal discomfort during prolonged sitting, and the global perceived improvement in the experimental group compared to the control group. Additionally, in the experimental group, the level of satisfaction with the intervention and possible changes in the flexibility of the hamstring will be presented.
Conclusions
As an increase in LBP frequency is observed, it seems justified to research to determine the effect of feasible and effective interventions in addressing LBP and perceived musculoskeletal discomfort in young people. The findings of this study might provide information about a 12-week intervention involving active hamstring flexibility exercises with hip flexion mobilization on reduction of LBP and musculoskeletal discomfort during prolonged sitting in young adults. We hope this study will help to develop ergonomic recommendations for young people with LBP.
Analysis of Near-Fault Ground Motions in the February 2023 Kahramanmaras, Türkiye, Earthquake Sequence
Authors: Chang Zhiwang , Wu Haoran , Li Wanheng , Yan Zhenxu , Peng Longqiang , Zhu Ge 
Published: April 2024

Abstract

The southern Türkiye and northern Syria areas were hit on February 2023 by a large earthquake with Mw=7.8, followed by another large aftershock with Mw=7.5. The two-earthquake sequence, coupled with a series of smaller aftershocks, caused severe structural and geotechnical damage and fatalities. The objective of this study is to investigate the characteristics of near-fault ground motions observed in the earthquake sequence. To this end, the ground motion intensity measures are firstly compared with existing models; it is shown that PGA and spectral accelerations from both the non-pulse-like and the pulse-like motions can be well captured by the Zhao et al. (2006) model. Subsequently, the velocity pulses in near-fault ground motions are not only quantitatively identified, but are also parameterized using the progressive iterative approach. The identified pulses are then empirically categorized into two groups of records with different causative effects according to the criterion of whether or not non-zero displacements could be visually inspected at the end of the integrated pulse displacement traces. Pulse-like ground motions containing baseline offset are also corrected, and final permanent displacements due to fling-step effects are accordingly derived. To determine the orientations at which the strongest pulses can be observed, two different approaches are employed. It is revealed that the indirect method by seeking the orientation of the maximum PGV appears to be not reliable if it is to find the strongest pulse, at least with respect to the 2023 Türkiye earthquake sequence.
In Silico Molecular Docking Studies of Plumbago Zeylanica L. Against Androgen receptor in Prostate cancer
Authors: Lakshmi S Siva , Aishwarya A. , Monika T. , H Vetha Merlin Kumari , kantham T. Lakshmi , Meenakumari R. 
Published: April 2024

Abstract

Introduction:
In Siddha medicine, a number of herbs are mentioned as possible cancer therapies, both alone and in combination. Such one of the best herb mention in siddha literature is Ven Kodiveli/ Ven chithramoolam. (Plumbago zeylanica L.) which is an extremely powerful herb with wide distribution, and also component of many Siddha drugs Like Chitramoola kuligai, chithramoola thylam etc. In that chithra moola kuligai is specially indicated for Yoni putru (Vaginal cancer), linga putru (Penile cancer, Prostate cancer), Vippuruthi (All types of cancers). The objective of this study is performing in silico computational analyses of phytoconstituents in extracts of the root of Plumbago zeylanica against antrogen receptor for prostate cancer
Methodology:
Docking calculations were carried out for retrieved phytocomponents of Plumbago zeylanica against the target Androgen receptor. Essential hydrogen atoms, Kollman united atom type charges, and solvation parameters were added with the aid of AutoDock tools .
Observation and inference:
Total of 5 bioactive lead compounds were retrieved from the herbal ingredients. From reported data of the herb, the phytochemicals such as Lupeol and Stigmasterol reveals maximum of 5 interactions followed by which the compounds such as Plumbagin, Oleic Acid and β-Asarone reveals maximum of 4 interactionswith the core active amino acid residues present on the target androgen receptor.
Conclusion:
Based on the results of the computational analysis it was concluded that the bio-active compound’s like Lupeol and Stigmasterol, Plumbagin, Oleic Acidand β-Asarone present in the herbal ingredients possess significant binding affinity towards androgen receptor thereby it may greatly inhibits progression of prostate cancer. Further clinical trials would be beneficial in determining whether this herb is an effective therapy for prostate cancer.
Emergence of SARS-CoV-2 Omicron Variant JN.1 in Tamil Nadu, India - Clinical Characteristics and Novel Mutations
Authors: Selvavinayagam Sivaprakasam T. , Sankar Sathish , Yong Yean Kong , Murugesan Amudhan , Suvaithenamudhan Suvaiyarasan , Hemashree Kannan , Rajeshkumar Manivannan , Kumaresan Anandhazhvar , Pandey Ramendra Pati , Shanmugam Saravanan , Arthydevi Parthiban , Kumar Masilamani Senthil , Gopalan Natarajan , Kannan Meganathan , Cheedarla Narayanaiah , Tan Hong Yien , Zhang Ying , Larsson Marie , Balakrishnan Pachamuthu , Velu Vijayakumar , Byrareddy Siddappa N. , Shankar Esaki Muthu , Raju Sivadoss 
Published: April 2024

Abstract

In December 2023, we observed a notable shift in the COVID-19 landscape, when the JN.1 emerged as a predominant SARS-CoV-2 variant with a 95% incidence. We characterized the clinical profile, and genetic changes in JN.1, an emerging SARS-CoV-2 variant of interest. Whole genome sequencing was performed on SARS-CoV-2 positive samples, followed by sequence analysis. Mutations within the spike protein sequences were analyzed and compared with the previous lineages and sublineages of SARS-CoV-2, to identify the potential impact of these unique mutations on protein structure and possible functionality. Several unique and dynamic mutations were identified herein. Our data provides key insights into the emergence of newer variants of SARS-CoV-2 in our region and highlights the need for robust and sustained genomic surveillance of SARS-CoV-2.
An engineered imine reductase for highly diastereo- and enantioselective synthesis of β-branched amines with contiguous stereocenters
Authors: Zhu Zhen-Yu , Shi Min , Gao Yun-Fei , Shen Xin-Yuan , Ding Xu-Wei , Li Chen-Lin , Fei-FeiChen  , Xu Jian-He , Chen Qi , Zheng Gao-Wei 
Published: April 2024

Abstract

βBranched chiral amines with contiguous stereocenters are valuable building blocks for preparing various biologically active molecules. However, their asymmetric synthesis remains challenging. Herein, we report a highly diastereo- and enantioselective biocatalytic approach for preparing a broad range of β-branched chiral amines starting from their corresponding racemic ketones. This involves a dynamic kinetic resolution-asymmetric reductive amination process catalyzed using only an imine reductase. Four rounds of protein engineering endowed wild-type PocIRED with higher reactivity, better stereoselectivity, and a broader substrate scope. Using the engineered enzyme, various chiral amine products were synthesized with up to > 99.9% ee, > 99:1 dr, and > 99% conversion. The practicability of the developed biocatalytic method was confirmed by producing a key intermediate of tofacitinib in 74% yield, > 99.9% ee, and 98:2 dr at a challenging substrate loading of 110 g L− 1. Our study provides a highly capable imine reductase and a protocol for developing an efficient biocatalytic dynamic kinetic resolution-asymmetric reductive amination reaction system.
Chemical composition, antifungal and antioxidant properties of seasonal variation in Eucalyptus tereticornis leaves of essential oil
Authors: Khaiper Mamta , Poonia P. K. , Redhu Ishu , Verma Preety , Nasir Mohammed , Tiwari Anjali , Kumar Vikas 
Published: April 2024

Abstract
The study aims to evaluate the chemical composition and anti-microbial activities of essential oils (EOs) extracted from fresh and shed dried leaves of Eucalyptus tereticornis clone C-83 during three consecutive seasons - winter, summer and rainy to determine the best harvesting time for obtaining the highest essential oil yield. The chemical composition was analyzed using a Gas Chromatography–Mass Spectrophotometry (GC-MS) and major compounds in fresh leaves oil were Eucalyptol (54.88%), Camphene (30.40%), α-Eudesmol (22.44%) and 3-Carene (19.50%). Dry leaf oil predominantly comprised Isopulegol (53.53%), 3-Isopropenyl-6-methyl-1-cyclohexene (17.29%) and Cis-Sabinene hydrate (13.55%). Isoterpinolene held a substantial presence at 5.61%, while Guaiol notably contributed at 2.49%. 2-isopropyl-4-methyl-2,5-dihydrooxazole registered at 2.32%, indicating its significant presence in the analyzed composition. Additionally, Bicyclogermacrene and Bicyclo[5.2.0]nonane, 2-methylene-4,8,8-trimethyl-4-vinyl-, exhibited noticeable percentages at 1.43% and 1.32%, respectively, underscoring their relative abundance within the sample. It revealed a concentration dependent rise in antioxidant effectiveness, with summer consistently exhibiting the highest radical scavenging potential of 93.58% at 4% concentration. Additionally, the oil showed antifungal properties against four plant-damaging fungi- Magnaporthe grisea, Rhizoctonia solani, Rhizoctonia bataticola and Fusarium oxysporum- signifying potent antifungal properties in eucalyptus oils. The radical scavenging activity with increasing concentration across all seasons, showcasing higher efficacy as the concentration of essential oil rises, with the summer season consistently displaying the highest antioxidant potential across all concentrations. The study enhances comprehension of EOs and offers a pharmacological analysis, potentially advancing its exploration as a functional drug in agricultural and cosmetic sectors.
Predicting full retirement attainment of NBA players
Authors: Foutzopoulos Giorgos , Tsagris Michail , Pandis Nikolaos 
Published: April 2024

Abstract
The aim of this analysis is to predict whether an NBA player will be active in the league for at least 10 years so as to be qualified for NBA's full retirement scheme which allows for the maximum benefit payable by law. We collected per game statistics for players during their second year, drafted during the years 1999 up to 2006, for which information on their career longetivity is known. By feeding these statistics of the sophomore players into statistical and machine learning algorithms we select the important statistics and manage to accomplish a satisfactory predictability performance. Further, we visualize the effect of each of the selected statistics on the estimated probability of staying in the league for more than 10 years.
Pilosella multiflora, der korrekte Name für Pilosella guthnikiana
Authors: Gottschlich Günter 
Published: April 2024

Eine bislang unberücksichtigt gebliebene Publikation von Gaudin (1820) macht eine Umbenennung von Pilosella guthnikiana zu P. multiflora nötig. Für das Basionym Hieracium multiflorum Schleich. ex Gaudin wird ein Schleicher-Beleg aus dem Herbarium Lausanne (LAU-0122837) als Neotypus festgelegt und dieser abgebildet. Zwei zugehörige Unterarten werden zu P. multiflora kombiniert.
Smart Nanobiomaterials for Gene Delivery in Localized Cancer Therapy: An Overview from Emerging Materials and Devices to Clinical Applications
Authors: Shamaeizadeh Armin , Beigi Anahita , Naghib Seyed Morteza , Tajabadi Maryam , Rahmanian Mehdi , Mozafari M. R. 
Published: April 2024

Abstract:
Researchers in various fields continue to discover improved ways of local delivery of
drugs to specific locations and try to increase the efficiency of these methods. Extensive research
has been done on smart nano-biomaterials for drug delivery systems (DDS) in different dimensions.
With the advancement of biomedical nanotechnology, conventional smart DDS with stimuli-
responsive capability has been developed. Smart nano-biomaterials can respond to environmental
changes caused by endogenous or exogenous elements: endogenous factors such as environmental
pH, temperature gradient, enzymes, oxidation, and reduction potential. As well as exogenous
factors, including light radiation, ultrasound, electric and magnetic fields. Currently, smart
DDSs count as a major category in DDS and disease treatment. Currently, smart DDS are of great
interest in drug delivery and treatment of diseases. With the improvements in gene and protein
therapy, new methods have been presented to treat diseases without effective conventional treatment,
especially cancer. Finally, the use of nanoparticles expanded due to the need for appropriate
gene and protein delivery systems. This review discusses the advantages of protein and gene therapy,
their challenges, and gene and protein delivery systems with nanoparticle-based delivery.
The Gold Standard Diagnosis of Schizophrenia is Counterproductive: Towards Quantitative Research and Diagnostic Algorithmic Rules (RADAR) and their Derived Qualitative Distinct Classes
Authors: Maes Michael 
Published: April 2024

:
Recently, we developed Research and Diagnostic Algorithm Rules (RADAR) to assess
the clinical and pathway features of mood disorders.

:
The aims of this paper are to review a) the methodology for developing continuous RADAR
scores that describe the clinical and pathway features of schizophrenia, and b) a new method to visualize
the clinical status of patients and the pathways implicated in RADAR graphs.

:
We review how to interpret clinical RADAR scores, which serve as valuable tools for monitoring
the staging of illness, lifetime suicidal behaviors, overall severity of illness, a general cognitive decline
index, and a behavior-cognitive-psychosocial (BCPS) index that represents the “defect”; and
b) pathway RADAR scores which reflect various protective (including the compensatory immune-
inflammatory system) and adverse (including neuro-immune, neuro-oxidative, and neurotoxic
biomarkers) outcome pathways. Using RADAR scores and machine learning, we created new,
qualitatively different types of schizophrenia, such as major neurocognitive psychosis and simple
psychosis. We also made RADAR graphs, which give us a quick way to compare the patient's clinical
condition and pathways to those of healthy controls.

:
We generated a personalized fingerprint for each patient, encompassing various clinical and pathway
features of the disorder represented through RADAR graphs. The latter is utilized in clinical
practice to assess the clinical condition of patients and identify treatment-required pathways to
mitigate the risk of recurrent episodes, worsening BCPS, and increasing staging. The quantitative
clinical RADAR scores should be used in schizophrenia research as dependent variables and regressed
on the pathway RADAR scores.
Therapeutic Impact of Ginger and Flaxseed in the Realm of Functional
Foods
Authors: Nethaji Dakshan Kumar , Alagu Thirumurugan , Sankar Devarajan , Thiyagarajan Sathishkumar 
Published: April 2024

:
The efficacy of synthetic drugs in managing disease development and progression has
faced challenges amidst shifts in lifestyle and heightened health consciousness. As a result, medicinal
plants and seeds, with their constituent compounds, are gaining recognition for their potential
in treating various illnesses. Ginger and flaxseed, as long-established herbal remedies, have made
notable contributions to culinary and medicinal fields. Their robust flavor and aroma and anti-inflammatory,
antioxidant, and analgesic properties extend their use beyond culinary spice to medicinal
applications. Furthermore, their capacity to preserve food adds to their appeal, making ginger
and flaxseed powerful and multi-functional elements in food production and medicinal contexts.
This review highlights the therapeutic advantages of ginger and flaxseed in combating different
diseases, focusing on their unique characteristics attributable to bioactive components.
Design of Global RLC Interconnect Circuit with Analytical Delay Model
Authors: Bhardwaj Himani , Jain Shruti , Sohal Harsh 
Published: April 2024

Background:
With the advancement in technology nodes and scaling trends, the majority
of the device performance depends upon the interconnections made between two or more
devices. With these scaling trends, frequency plays a vital role. As the technology decreases, frequency
tends to rise to giga-hertz. This increase in frequency gives rise to inductance parameters
in the interconnect circuits. For long wires, the inductive impedance can become comparable to
the resistive component due to which performance degradation can be observed along with overshoot
and crosstalk issues that can no longer be ignored.

Method:
This article aims to examine the delay model and reconstruct an interconnect circuit that
serves as a transmission line, ranging in length from 1 mm to 10 mm.

Result:
By keeping the frequency high, low voltage and rise/ fall time, performance parameters
such as delay, power consumption, and overshoot are observed.

Conclusion:
The interconnect structure is compared with another state-of-the-art technique.
Psychometric Properties of the Metacognitions About Online Gaming Scale in the Chinese Population and Its Relationship With Internet Gaming Disorder: Cross-Sectional Study
Authors: Lin Shuhong , Chen Xinxin , Tan Linxiang , Liao Zhenjiang , Li Yifan , Tang Ying , Huang Qiuping , Shen Hongxian 
Published: April 2024

Background
Metacognitions about online gaming have been shown to be correlated with Internet Gaming Disorder (IGD). Knowledge of metacognitions about online gaming can help to understand IGD. The Metacognitions about Online Gaming Scale (MOGS) is a reliable and valid tool to measure specific metacognitions about online gaming in both adults and adolescents, which is lacking in China.

Objective
This study was conducted to assess the psychometric properties of the Chinese version of the MOGS (C-MOGS) and its relationship with IGD in the Chinese population.

Methods
A total of 772 Chinese individuals (age: mean 21.70, SD 8.81 years; age range: 13-57 years; 458/772, 59.3% male) completed a web-based questionnaire survey, including the C-MOGS and a battery of validated scales measuring IGD, gaming motives, depression, and anxiety.

Results
Through exploratory and confirmatory factor analyses, the 3-factor structure was confirmed to have adequate model fit and internal consistency reliability (Cronbach α≥.799, Guttman split-half coefficients≥0.754). Concurrent validity of the C-MOGS was supported by its correlations with IGD (P<.001), gaming motives (P<.001), depression (P<.001), and anxiety (P<.001). Furthermore, the incremental validity analysis showed that the C-MOGS predicted 13% of the variance in IGD while controlling for gender, age, weekly gaming hours, gaming motives, depression, and anxiety.

Conclusions
This study provides evidence that the psychometric properties of the C-MOGS are appropriate and emphasizes its positive association with IGD. The C-MOGS is a reliable and valid instrument for mental health workers to assess metacognitions about online gaming in the Chinese population.