bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stent sizing by coronary computed tomographic angiography: Comparison with conventional coronary angiography in an experienced setting
Authors: de Silva Ramesh , Mussap Christian J. , Hecht: Harvey S. , van Mieghem Nicolas M. , Matarazzo Thomas J. , Roubin Gary S. , Panagopoulos Georgia 
Published: July 2011

AbstractObjectives:The goal was to compare stent sizing by coronary computed tomographic angiography (CCTA) with that deployed in an experienced setting based upon conventional coronary angiography (CA).Background:Stent sizing is currently performed by visual estimation, with infrequent guidance by intravascular ultrasound. CCTA permits quantitative determination of stent length (Stent L) and diameter (Stent D).Methods:Projected L (CTA‐Stent L) and D (CTA‐Stent D) were determined from CCTA obtained in 248 patients with 352 lesions undergoing percutaneous coronary intervention within 4 months of the CCTA, and were compared to the Stent‐L and Stent‐D of the actually deployed stents. The effects of lesion modification and calcified plaque were also evaluated.Results:There were significant correlations between CTA‐Stent L and Stent L (r = 0.656, P < 0.0001) and between CTA‐Stent D and Stent D (r = 0.40, P < 0.001). Median predicted CTA‐Stent L was slightly longer (20 mm vs. 18 mm, P < 0.0001) and predicted CTA‐Stent D was slightly smaller (3.0 mm vs. 3.2 mm, P < 0.0001) than Stent‐L and Stent‐D, respectively. The differences were unchanged in stents with lesion modification by pre‐dilation or intracoronary nitroglycerin. CTA Stent‐L and CTA Stent‐D increased significantly with increasing calcium (P < 0.0001 and P = 0.019, respectively).Conclusions:(1) There are significant correlations between CCTA and CA based stent sizing in an experienced setting. (2) CCTA projects slightly longer and slightly smaller diameter stents than those deployed during PCI irrespective of lesion modification; the small differences are unlikely to have clinical significance. (3) CCTA may offer a noninvasive alternative to intravascular ultrasound for stent planning. © 2011 Wiley‐Liss, Inc.
Successful removal of an entrapped rotablation burr by extracting drive shaft sheath followed by balloon dilatation
Authors: Sakakura Kenichi , Ako Junya , Momomura Shin‐ichi 
Published: July 2011

AbstractBurr entrapment is a rare but serious complication during rotational atherectomy (RA). Although emergent surgical removal is a reliable option for this complication, surgical removal is invasive and takes several hours. Balloon inflation just proximal to the burr was the previously‐reported nonsurgical option for burr removal. However, this method needed large guide catheter lumen (≥8 Fr). We present a case of 67‐year‐old male on chronic hemodialysis. During RA for severe stenosis of the right coronary artery, the RA burr was entrapped. We cut off the drive shaft, the drive shaft sheath, and the RA wire together near the advancer, and then we removed the drive shaft sheath. After removing the drive shaft sheath, the 2.5 mm balloon easily entered the 7‐Fr guide catheter. We inflated that balloon to a pressure of 18 atm. The burr was easily removed immediately after balloon deflation. Removal of the drive shaft sheath following balloon dilatation is a new, nonsurgical bailout method for a burr that becomes entrapped during RA. Since removal of the drive shaft sheath following balloon dilatation can be applied to 7 Fr as well as 6 Fr guide systems, this method may be of considerable benefit when operators use 7 Fr or 6 Fr systems. © 2011 Wiley‐Liss, Inc.
Synthesis, Electronic, and Electro‐Optical Properties of Emissive Solvatochromic Phenothiazinyl Merocyanine Dyes
Authors: Hauck Martina , Stolte Matthias , Schönhaber Jan , Kuball Hans‐Georg , Müller Thomas J. J. 
Published: July 2011

AbstractPhenothiazinyl merocyanine dyes with variable substitution patterns on the peripheral benzene ring were synthesized in good yields by Knoevenagel condensation of the corresponding phenothiazinyl aldehydes andN‐methylrhodanine or indan‐1,3‐dione. The electronic properties were investigated by cyclic voltammetry, absorption, electro‐optical absorption, and emission spectroscopy. All these merocyanines reveal reversible redox behavior that stems from the phenothiazinyl‐centered oxidation to give stable radical cations. The redox potentials strongly correlate with Hammettσpparameters. All merocyanines reveal large Stokes shifts. They also display a pronounced emissive solvatochromism, which is caused by large dipole moment changes upon excitation from the ground to the excited state. These findings are supported by solvatochromism studies and time‐dependent DFT computations.
High‐Efficiency Tris(8‐hydroxyquinoline)aluminum (Alq3) Complexes for Organic White‐Light‐Emitting Diodes and Solid‐State Lighting
Authors: Pérez‐Bolívar César , Takizawa Shin‐ya , Nishimura Go , Montes Victor A. , Anzenbacher Pavel 
Published: July 2011

AbstractCombinations of electron‐withdrawing and ‐donating substituents on the 8‐hydroxyquinoline ligand of the tris(8‐hydroxyquinoline)aluminum (Alq3) complexes allow for control of the HOMO and LUMO energies and the HOMO–LUMO gap responsible for emission from the complexes. Here, we present a systematic study on tuning the emission and electroluminescence (EL) from Alq3 complexes from the green to blue region. In this study, we explored the combination of electron‐donating substituents on C4 and C6. Compounds 1–6 displayed the emission tuning between 478 and 526 nm, and fluorescence quantum yield between 0.15 and 0.57. The compounds 2–6 were used as emitters and hosts in organic light‐emitting diodes (OLEDs). The highest OLED external quantum efficiency (EQE) observed was 4.6 %, which is among the highest observed for Alq3 complexes. Also, the compounds 3–5 were used as hosts for red phosphorescent dopants to obtain white light‐emitting diodes (WOLED). The WOLEDs displayed high efficiency (EQE up to 19 %) and high white color purity (color rendering index (CRI≈85).
Cyclopropyl Carbinol Rearrangement for Benzo‐Fused Nitrogen Ring Synthesis
Authors: Kothandaraman Prasath , Huang Chuhui , Susanti Dewi , Rao Weidong , Chan Philip Wai Hong 
Published: July 2011

AbstractA synthetic method that relies on gold‐catalysed cyclopropyl carbinol rearrangement of 2‐tosylaminophenyl cyclopropylmethanols to prepare 2,3‐dihydro‐1H‐benzo[b]azepines and 2‐vinylindolines efficiently is reported. The reactions were shown to be chemoselective, with secondary and tertiary alcohol substrates exclusively providing benzo‐fused five‐ and seven‐membered ring products, respectively. The ring‐forming process was also found to proceed in moderate to excellent yields under mild conditions only in the presence of the gold and silver catalyst combination. The mechanism is thought to involve activation of the alcohol by the (p‐CF3C6H4)3PAuCl/AgOTf (Tf=triflate) catalyst, resulting in ionization of the starting material. The tertiary carbocationic intermediate generated in situ in this manner then triggers ring‐opening of the cyclopropane moiety and trapping by the tethered aniline group to give the 2,3‐dihydro‐1H‐benzo[b]azepine. Cyclopropane ring fragmentation of the secondary carbocationic analogue, on the other hand, results in diene formation followed by subsequent intramolecular hydroamination to afford the 2‐vinylindoline.
Identification of a mechanical hybrid system switched by the absolute value of velocity or displacement
Authors: Hirata Mitsuo , Noguchi Sakae , Adachi Shuichi 
Published: July 2011

AbstractIn this paper we propose a system identification method for hybrid systems switched according to the absolute value of the velocity or displacement. First, it is shown that the regression vector space of a mechanical system switched according to the absolute value of the velocity or displacement cannot be separated by a hyperplane. Then a method based on support vector machines with a polynomial kernel is proposed. The effectiveness of this method is shown by simulations using a spring‐mass‐damper system. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 94(8): 65–72, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10202
Decomposition and reconstruction of signal in high‐speed processing method of real‐time spectral analysis
Authors: Nakatsuji Hideto , Omatu Shigeru 
Published: July 2011

AbstractIn recent years, wavelet transforms based on multiresolution analysis have been considered as a concrete algorithm for an integral wavelet transform that performs spectral analysis in the time–frequency domain. On the other hand, we have proposed a new method of analysis that updates the spectrum using input data only. The new method consists of analysis approach 1, which is a fundamental analysis method, and analysis approach 2, which is an analysis method that achieves high‐speed processing. Decomposition and reconstruction of the signal based on analysis approach 1 has already been proposed by us. This paper describes the decomposition and reconstruction of a signal based on analysis approach 2. The decomposition wave in analysis approach 2 cannot be obtained by the same method as in the case of analysis approach 1, but requires mathematical processing. In the processing, the decomposition wave in analysis approach 2 is identical to the decomposition wave in analysis approach 1. Therefore, the decomposition and reconstruction of the signal in analysis approach 2 results in the decomposition and reconstruction of the signal in analysis approach 1. As an example of numerical analysis, we illustrate the decomposition and reconstruction of the Japanese vocal sound /i/. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 94(8): 47–56, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10250
Map retrieval based on geometric spatial relations
Authors: Shimizu Toru , Ikezaki Masakazu , Ushiama Taketoshi , Watanabe Toyohide 
Published: July 2011

AbstractUntil now, many researchers have proposed spatial relations between geographical objects in the field of geographical information systems and spatial databases. However, these proposals have focused on binary relations to represent the features of geographical objects, but have not concentrated on the complexity among geographical objects. In this paper, we aim to model the complex structure among geographical objects. To represent the structure among geographical objects, we define the geometric spatial relation, which is composed of an overlapping relation, an adjoining relation, and a neighboring relation. Additionally, we discuss a retrieval function which finds similar locations by using a sketch as a query. In order to find locations, we generate a graph structure for representing the relationships among geographical objects using the three relations. We find a similar structure by comparing two graph structures. To judge the occurrence of a similar structure, we define the similarity which is calculated by correspondence among relations. The correspondence among relations is a value which shows the difference between a query and data. By using this similarity, we can find not only subgraphs but also similarity graphs. © 2011 Wiley Periodicals, Inc. Electron Comm Jpn, 94(8): 27–36, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.10345
Syntheses, Structures and Reactivity of New Intramolecularly Coordinated Tin Alkoxides Based on an Enantiopure Ephedrine Derivative
Authors: Iovkova‐Berends Ljuba , Berends Thorsten , Dietz Christina , Bradtmöller Gerrit , Schollmeyer Dieter , Jurkschat Klaus 
Published: July 2011

AbstractThe syntheses of the tin compounds [LSn]2 (2), spiro‐L2Sn (3), [LSnW(CO)5]2 (4), [LSnBr2]2 (5), spiro‐L2Sn·SnBr4 (6) and LSn[OC(O)Ph]2 (8), where L = MeN(CH2CMe2O)[(S)‐CH(Me)‐(R)‐CH(Ph)O], and (Ph4P)2SnBr6 (7) are reported. The compounds were characterized by elemental analysis, multinuclear NMR spectroscopy including 119Sn cross polarisation–magic angle spinning NMR (CP–MAS) (2, 3–6), electrospray ionization mass spectrometry (2–4) and single crystal X‐ray diffraction analysis (2, 2·C7H8, 3a, 3b, 4·C7H8, 5, 6·C7H8, 7).
Enantioselective Total Synthesis of (–)‐Subglutinols A and B: Potential Immunosuppressive Agents Isolated from a Microorganism
Authors: Kikuchi Takuya , Mineta Mayuko , Ohtaka Jingo , Matsumoto Naoko , Katoh Tadashi 
Published: July 2011

AbstractPotential immunosuppressive diterpenoid pyrones (–)‐subglutinols A and B were efficiently synthesized in an enantioselective manner starting from a known trans‐decalone derivative. The synthetic method involved the following key steps: (i) [2,3]‐Wittig rearrangement of a stannyl methyl ether to access the requisite decalin segment; (ii) coupling of the decalin segment with a γ‐pyrone moiety to set up the desired carbon framework; (iii) construction of a characteristic tetrahydrofuran ring in one‐pot fashion through an internal SN2‐type cyclization, and (iv) conversion of a γ‐pyrone moiety into an α‐pyrone ring to yield the target (–)‐subglutinols A and B.
A one‐pot synthesis of alkynyl sulfides from terminal alkynes
Authors: Zheng Weixin , Zheng Fenfen , Hong Ya , Hu Linfeng 
Published: July 2011

AbstractA one‐pot synthesis of alkynyl sulfide from terminal alkyne has been reported via lithiation of the alkyne, oxidative addition of sulfur, consecutively followed by the nucleophilic substitution of lithium alkynyl thiolate to various halides. © 2011 Wiley Periodicals, Inc. Heteroatom Chem 23:105–110, 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.20745
Computational modeling and analysis of thermal characteristics of a rotating spacecraft subjected to solar radiation
Authors: Gadalla Mohamed A. , Wahba Essam 
Published: July 2011

AbstractThis paper presents a computational modeling for the temperature distribution of a rotating thick‐walled cylindrical spacecraft subjected to solar radiation. The inner surface of the spacecraft is thermally insulated while the outer surface is subjected to concurrent events of solar incidence and radiative heat dissipation to space. The governing equation for the normalized temperature is discretized using a finite difference scheme and Successive Line Over‐Relaxation (SLOR) is used to solve the resulting system of algebraic equations. Numerical simulations of temperature distribution on the spacecraft for different spinning speeds, angular positions, and different radii are discussed and evaluated for both linearized and nonlinear boundary conditions. Comparative analysis between the computational modeling and the exact analytical solution for the linearized boundary condition is presented. The results indicate that the outer surface temperature distribution of the spacecraft is nearly independent of the angular position; at sub‐cylindrical surface, this independence is achieved at low angular velocity. Moreover, numerical simulations show that the use of the linearized boundary condition at the outer surface presents a good approximation for the case of high‐speed spinning spacecrafts, while it results in significant errors in the temperature field in the case of stationary and low‐speed spinning spacecrafts. © 2011 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.20368
Pharmacokinetic parameters from 3‐Tesla DCE‐MRI as surrogate biomarkers of antitumor effects of bevacizumab plus FOLFIRI in colorectal cancer with liver metastasis
Authors: Hirashima Yoshinori , Yamada Yasuhide , Tateishi Ukihide , Kato Ken , Miyake Mototaka , Horita Yosuke , Akiyoshi Kohei , Takashima Atsuo , Okita Natsuko , Takahari Daisuke , Nakajima Takako , Hamaguchi Tetsuya , Shimada Yasuhiro , Shirao Kuniaki 
Published: July 2011

AbstractBevacizumab (BV) is an antivascular endothelial growth factor antibody. When administered with other chemotherapeutic drugs, BV‐combined regimens prolong survival of colorectal cancer patients. We conducted a phase II trial to confirm the pharmacokinetic parameters from 3‐Tesla dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) as surrogate biomarkers of BV + FOLFIRI regimen efficacy in colorectal cancer with liver metastases. DCE‐MRI was performed before treatment, on the seventh day after first treatment and every 8 weeks thereafter using a 3‐Tesla MRI system. DCE‐MRI parameters‐area under the contrast concentration versus time curve at 90 and 180 s (AUC90 and AUC180, respectively) after contrast injection, and volume transfer constant of contrast agents (Ktrans and Kep) were calculated from liver metastases. Fifty‐eight liver metastases were analyzed. Univariate analysis revealed that a decrease in Ktrans ratios (ΔKtrans), Kep ratios (ΔKep), AUC90 ratios (ΔAUC90) and AUC180 ratios (ΔAUC180) correlated with higher response (all p < 0.0001) and longer time to progression (TTP) (ΔKtrans: p = 0.001; ΔKep: p = 0.004; ΔAUC90: p = 0.006; ΔAUC180: p < 0.0001). Multivariate analysis showed that ΔAUC180 was correlated with higher response (p = 0.009), and ΔKtrans and ΔAUC180 were correlated with longer TTP (ΔKtrans: p = 0.001; ΔAUC180: p = 0.024). ΔKtrans and ΔAUC180 are pharmacodynamic biomarkers of the blood perfusion of BV + FOLFIRI. Our data suggest that ΔKtrans and ΔKep can predict response to chemotherapy at 1 week. Changes in 3‐Tesla DCE‐MRI parameters confirmed the potential of these biomarkers of blood perfusion as surrogate predictors of response and TTP.
Clinicopathologic factors associated with HER2‐positive gastric cancer and its impact on survival outcomes—A systematic review
Authors: Chua Terence C. , Merrett Neil D. 
Published: July 2011

AbstractWith the availability of a therapeutic target and an effective agent in trastuzumab, a systematic examination of the literature to investigate the role of human epidermal growth factor 2 (HER2) as a prognostic factor for survival and its association with clinicopathologic markers may improve treatment. An electronic search of the MEDLINE and PubMed databases (January 1990 to January 2011) was undertaken to identify translational studies that correlated HER2 with clinicopathologic markers and/or survival outcome. This review included 49 studies totaling 11,337 patients. Forty‐four percent of patients had Stage I/II, and 56% had Stage III/IV disease. Immunohistochemistry was most commonly used to assess HER2 expression, identifying a median rate of 18% (range, 4–53%) of gastric cancer demonstrating HER2 overexpression. In patients with and without HER2 overexpression, the median 3‐year disease‐free survival rate was 58% (range, 50–88%) and 86% (range, 62–97%), respectively. Of the 35 studies reporting the impact of HER2 overexpression on survival, 20 studies (57%) reported no difference in overall survival, two studies (6%) reported significantly longer overall survival in patients with HER2 overexpression and 13 studies (37%) reported significantly poorer overall survival in patients with HER2 overexpression. The median overall survival and 5‐year survival rate was 21 (range, 10–57) months and 42%, and 33 (range, 13–80) months and 52% in patients with and without HER2 overexpression, respectively. HER2 overexpression appears to be associated with poorer survival and with intestinal‐type gastric cancer in this group of patients for whom majority undergone curative gastrectomy.
Endocrine and testicular changes induced by olanzapine in adult Wistar rats
Authors: de Siqueira Bringel Simone , de Amorim Júnior Adelmar Afonso , Amorim Marleyne José Afonso Accioly Lins , Brito Lorena Tavares , Morais Rosana Nogueira , de Torres Sandra Maria , Tenorio Bruno Mendes , da Silva Junior Valdemiro Amaro 
Published: July 2011

ABSTRACTOlanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen‐dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis. Copyright © 2011 John Wiley & Sons, Ltd.
Molecular basis of calcium binding by polyguluronate chains. Revising the egg‐box model
Authors: Plazinski Wojciech 
Published: July 2011

AbstractThe egg‐box model is the commonly accepted description of the calcium alginate/guluronate structure. It assumes that calcium ions are bound in the periodic chelation sites located between two polyuronate chains. This study was focused on elucidating the nature of interactions between calcium and polyuronates, responsible for the Ca2+‐induced association of polyuronate chains in the aqueous solutions. Both molecular dynamics and semiempirical (ZINDO‐1/Monte Carlo) methods were used for this purpose. Based on the obtained results, new structural models of Ca2+‐polyguluronate complexes were proposed both for parallel and antiparallel pairing. Contrary to the classical egg‐box model, Ca2+ ions are coordinated by four carboxyl oxygens from two opposite carboxyl groups belonging to two different polyguluronate chains and, additionally, by four oxygen atoms belonging to water molecules. Such a coordination pattern can be interpreted as the result of competition between water molecules and carboxylic groups of polyguluronate for calcium ions. Other structural details (the network of hydrogen bonds, for instance) are close to those corresponding to the “shifted” egg‐box model proposed by Braccini and Pérez (Biomacromolecules 2001, 2, 1089) and remain in agreement with the experimental data. © 2011 Wiley Periodicals, Inc. J Comput Chem, 2011
Src family kinases regulate renal epithelial dedifferentiation through activation of EGFR/PI3K signaling
Authors: Zhuang Shougang , Duan Meili , Yan Yan 
Published: July 2011

AbstractDedifferentiation, a process by which differentiated cells become mesenchymal‐like proliferating cells, is the first step in renal epithelium repair and occurs in vivo after acute kidney injury and in vitro in primary culture. However, the underlying mechanism remains poorly understood. In this report, we studied the signaling events that mediate dedifferentiation of proximal renal tubular cells (RPTC) in primary culture. RPTC dedifferentiation characterized by increased expression of vimentin concurrent with decreased expression of cytokeratin‐18 was observed at 24 h after the initial plating of freshly isolated proximal tubules and persisted for 72 h. At 96 h, RPTC started to redifferentiate as revealed by reciprocal expression of cytokeratin‐18 and vimentin and completed at 120 h. Phosphorylation levels of Src, epidermal growth factor receptor (EGFR), AKT (a target of phosphoinositide‐3‐kinase (PI3K)), and ERK1/2 were increased in the early time course of culture (<72 h). Inhibition of Src family kinases (SFKs) with PP1 blocked EGFR, AKT, and ERK1/2 phosphorylation, as well as RPTC dedifferentiation. Inhibition of EGFR with AG1478 also blocked AKT and ERK1/2 phosphorylation and RPTC dedifferentiation. Although inactivation of the PI3K/AKT pathway with LY294002 inhibited RPTC dedifferentiation, blocking the ERK1/2 pathway with U0126 did not show such an effect. Moreover, inhibition of SFKs, EGFR, PI3K/AKT, but not ERK1/2 pathways abrogated RPTC outgrowth and SFK inhibition decreased RPTC proliferation and migration. These findings demonstrate a critical role of SFKs in mediating RPTC dedifferentiation through activation of the EGFR/PI3K signaling pathway. J. Cell. Physiol. 227: 2138–2144, 2012. © 2011 Wiley Periodicals, Inc.