bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perceptual Attention and Subjective Belief about Risk Alters Heartbeat-evoked Response
Authors: Bong Su Hyun , Yoon Dayoung , Kim Jaewon , Jeong Bumseok 
Published: June 2024

Abstract

Heartbeat-evoked responses (HER) can be interpreted as prediction error signals modified by precision, which in turn are influenced by interoceptive attention. However, changes in interoceptive information processing that occur while computing or focusing on uncertain external environments have yet to be explored. This study examines alterations in HER driven by both interoceptive and exteroceptive attention. We suggest that variations in HER under different conditions could serve as unique neurobiological markers for individuals. Through behavioral modeling and electroencephalogram analysis, we verified HER changes when modifying subjective beliefs based on calculated risk from the external environment. This study demonstrates that the brain’s response to interoceptive information transcends mere sensation representation, instead reflecting subjective beliefs regarding one’s body and the external environment.
Internet Use, Depression and Elderly Well-Being in China
Authors: Wang Xuehui 
Published: June 2024

Abstract

Background With China's rapidly aging population and increasing elderly internet users, the study aims to investigate the relationship between internet usage and subjective well-being among older Chinese adults, focusing on the mediating role of depression. The research is set against the backdrop of China's elderly population growth and the widespread adoption of the internet, which has been linked to mental health benefits such as reduced loneliness and increased social support.
Methods The study utilizes data from the 2020 China Family Panel Study (CFPS), employing a path model to analyze the mediating effect of depression on the association between internet use and subjective well-being. The sample size, after exclusion criteria, was 4671 participants aged 60 or above. Subjective well-being was measured by happiness, internet use by mobile or computer access, and depression by the CESD scale. Parent-child relationship quality and other covariates were also assessed.
Results The findings indicate that frequent internet use is positively associated with higher levels of subjective well-being in older adults. Depression was identified as a significant mediator, suggesting that internet use can enhance subjective well-being by reducing depressive symptoms. The study also found gender differences, with internet use having a more pronounced effect on male participants' well-being.
Conclusions The research concludes that internet use is beneficial for the subjective well-being of older adults, particularly for those with depressive symptoms. The study suggests that improving internet skills and access for the elderly could be integral to mental health promotion strategies and overall well-being enhancement in later life. The findings highlight the importance of considering depression as a mediating factor in the context of internet use and well-being among the elderly population.
The effect of prenatal education on exclusive breastfeeding among women in Quito. Prospective cohort study
Authors: Tello Betzabé , Hernández Herminio , Dueñas-Espín Iván , Tejera Eduardo 
Published: June 2024

Abstract

Background: Breast milk is the optimal food for humans, however, many mothers encounter difficulties sustaining exclusive breastfeeding (EBF). Prenatal education (PE) has been suggested as a potential strategy to promote EBF. There remains a gap in understanding how PE influences EBF duration.
Methods: This prospective cohort study aimed to evaluate the effect of PE on EBF continuation among mothers who gave birth in private and public hospitals in Quito, Ecuador. A total of 278 participants were recruited, with 152 receiving PE and 126 not receiving it. Data was collected through structured surveys. Baseline clinical information was obtained through face-to-face interviews conducted after delivery and before discharge. Then, follow-up telephone interviews were conducted at one, four, and six months postpartum.
Results: Comparisons between the exposed (PE) and unexposed groups revealed significant differences in education level, health insurance, antenatal care visits, rooming-in rates, parity, and maternal breastfeeding (BF) intentions. Participants who received PE demonstrated a significantly longer mean duration of EBF compared to those who did not (89.4 ± 77.2 days vs. 66.1 ± 70.2 days, p = 0.004). The incidence rate of EBF abandonment was 11.81 per 100 person-months in the PE group and 14.91 per 100 person-months in the non-PE group. Cox survival analysis indicated a lower risk of EBF cessation among mothers who received PE (adjusted hazard ratio [aHR] = 0.58, 95% CI = 0.40-0.84, p = 0.004). Other factors associated with EBF discontinuation included delivery at a public health facility, postpartum depression, specific reasons for stopping BF, insufficient supply, return to work, healthcare provider recommendations, family advice, and negative BF experiences.
Conclusion: Standardized PE programs have a significant and independent positive impact on EBF duration among mothers in Quito, Ecuador. These findings underscore the importance of integrating PE into routine prenatal care and providing comprehensive postpartum support to promote BF continuation. It is necessary to develop targeted interventions to address modifiable risk factors for BF cessation.
Individual and neighborhood determinants of depressive symptoms in ethnic minorities in the urban HELIUS sample: a multi-level network perspective
Authors: Huth Karoline , Wal Junus van der , Zavlis Orestis , Luigjes Judy , Lakerveld Jeroen , Galenkamp Henrike , Lok Anja , Stronks Karien , Bockting Claudi , Marsman Maarten , Goudriaan Anneke , Holst Ruth van 
Published: June 2024

Abstract

Ethnic minorities in Europe experience an increased risk of depressive symptomatology. This is believed to be the result of the interplay between different factors at the individual (e.g., psychological, socioeconomic, cultural) and the neighborhood level (e.g., social cohesion, resources, ethnic diversity). This study sheds light on the interplay between variables using cross-sectional data from 13,507 individuals from five ethnic minority groups from the Healthy Life in Urban Setting (HELIUS) study in Amsterdam, the Netherlands. We developed a novel multilevel network analysis to explore the conditional associations between factors of interest for the entire group, and deviations from these effects for each ethnic subgroup.
Across all groups, unemployment, perceived stress, and adverse experiences were most strongly connected to depressive symptoms, while other individual factors such as perceived ethnic discrimination were connected indirectly.
While individual psychological factors remain the strongest predictors of depressive symptomatology, socio-demographic and cultural determinants underly these psychological factors.
Cytogenomic and phylogenomic evidence for new infrageneric relationships in Macroptilium (Benth.) beans
Authors: Montenegro Claudio , Ibiapino Amália , Nascimento Thiago , Costa Antônio Félix da , Brasileiro-Vidal Ana Christina , Pedrosa-Harand Andrea 
Published: June 2024

Abstract

Macroptilium (Benth.) Urb. is a forage genus native to regions from North to South America. Phylogenetic analyses place it close to Phaseolus L., but its infrageneric division into two sections is not well supported. Despite its chromosomal number stability (2n = 22), interspecific rDNA loci variation enabled species differentiation, suggesting that a cytogenomic approach might be valuable for inferring species relationships and genome evolution. Here, we (1) characterized nine Macroptilium species through oligonucleotide-based chromosome painting and barcoding (Oligo-FISH); (2) generated genome skimming data for six species and used it to investigate their repeatome dynamics, and (3) performed phylogenomic reconstruction using complete plastomes. Oligo-FISH data unveiled de novotranslocations between chromosomes 2 and 6, and 3 and 11 in species from proposed groups II and III, respectively, in disagreement with the currently proposed phylogenetic hypothesis. Our phylogenomic (plastid) and repeatome (nuclear) analyses supported groups II and III as clades, with shared satDNA families. Group I was paraphyletic and resembled the Ancestral Phaseolinae Karyotype. We demonstrated the efficiency of different cytogenomic approaches to characterize Macroptilium species, providing insights into its genomic evolution and indicating the need for a systematic re-evaluation of the genus. These findings also support the power of these approaches to solve phylogenetic relationships even in groups with chromosome number stability and recent diversification.
Advancement in Healthcare System: AL, ML, and Blockchain for Personalized Genomic Applications
Authors: Garg Hari Krishna 
Published: June 2024

Abstract

Individual genome projects have not been discussed in quite some time, possibly for various reasons. However, despite best efforts, there remains a need to establish a means by which individuals can benefit from the reference genome—a significant outcome of the Human Genome Project—and effectively utilize it. In light of this, a personalized genomic application has been visualized as a potent transformative tool accessible to people globally. An integrated framework has been proposed that melds blockchain technology, genome-tailored applications, and data compression techniques to ensure swift, secure, transparent, and space-efficient operations.
This software leverages advanced Artificial Intelligence and Machine Learning methodologies, including neural networks, fuzzy logic, and expert systems, to process individual genomic data. Reports are then generated based on insights gleaned from the user's genome, compared to a reference genome to detect any disparities. Given the security, encryption, and immutability features of blockchain technology, it proves apt for both data transport and storage. Moreover, a technique called 'Data Abbreviation' has been devised to ensure that genetic data and generated reports occupy less space. All of this could contribute to a transformative step toward the greater good of humanity.
Integrating Marketing Channels into Quantile Transformation and Bayesian Optimization of Ensemble Kernels for Sales Prediction with Gaussian Process Models
Authors: Mirshekari Shahin , Motedayen Negin Hayeri , Ensaf Mohammad 
Published: June 2024

Abstract

This study introduces an innovative Gaussian Process (GP) model utilizing an ensemble kernel that integrates Radial Basis Function (RBF), Rational Quadratic, and Matérn kernels for product sales forecasting. By applying Bayesian optimization, we efficiently find the optimal weights for each kernel, enhancing the model’s ability to handle complex sales data patterns. Our approach significantly outperforms traditional GP models, achieving a notable 98% accuracy and superior performance across key metrics including Mean Squared Error (MSE), Mean Absolute Error (MAE), Root Mean Squared Error (RMSE), and Coefficient of Determination (R2). This advancement underscores the effectiveness of ensemble kernels and Bayesian optimization in improving predictive accuracy, offering profound implications for machine learning applications in sales forecasting.
The therapeutic features of EGFR L858R exon 21 mutation in non-small cell lung cancer
Authors: Mandrina M. O. , Barbolina T. D. , Vladimirova L. Yu. , Storozhakova A. E. , Laktionov K. K. 
Published: June 2024

Introduction. Monotherapy with EGFR tyrosine kinase inhibitors (TKIs) results in a worse prognosis for patients with the exon 21 L858R mutation than for patients with exon 19 Del. Thus, the search for alternative drug strategies that improve treatment outcomes for patients with NSCLC with the L858R mutation is an urgent problem. This article presents preliminary results of a pilot study of the effectiveness of chemotherapy integrated into targeted anti-EGFR therapy for patients with non-small cell lung cancer (NSCLC) with a mutation in exon 21 of the EGFR gene.Aim. To improve progression-free survival results on first-line therapy in patients with NSCLC with the L858R mutation.Materials and methods. From 2015 to 2021 23 patients were included in the study with advanced L858R 21 exon mutation NSCLC for the first line of treatment. Patients received TKI therapy for the first 2 months, followed by discontinuation of targeted therapy and receiving 3 courses of paclitaxel and carboplatin. Target therapy was then resumed until disease progression. The follow up period was 36 months.Results. The objective response rate (ORR) was 59.1%. Median progression-free survival 23 months [95% CI: 16–36]. Four (18.1%) patients developed grade 3-4 toxicity during chemotherapy, and therefore the 3rd course of chemotherapy was canceled in one patient. Due to toxicity during targeted therapy, gefitinib dose was reduced in one patient and the drug was changed from gefitinib to afatinib in the other one patient.Conclusion. Preliminary results of our study showed that integrating chemotherapy into targeted treatment for this category of patients may become a new worthy option to increase median PFS.
Unveiling the Potential of Piper cubeba L. f.: A Comprehensive
Review Covering its Phytochemistry, Pharmacology, and Cutting-edge
Applications
Authors: Singh Sonia , Sharma Khushi 
Published: June 2024

Abstract::
Cubeb, often referred to as Piper cubeba (Piperaceae), has a long history in traditional
herbal medicine, particularly in the management of digestive and respiratory disorders. The plant
is a valuable source of essential oils, which are very important economically and are mostly found
in its fruits. Recent research has validated many of the traditional applications and their bioactive
components, highlighting their antibacterial, antioxidant, anticancer, and anti-inflammatory properties.
This article presents a contemporary summary of bioactive compounds and the pharmacological
properties of plants. It also explores the potential of plant P. cubeba for future applications
in promoting health and nutrition.
Reforming China’s Secondary Vocational Medical Education: Adapting to the Challenges and Opportunities of the AI Era
Authors: Tong Wenting , Zhang Xiaowen , Zeng Haiping , Pan Jianping , Gong Chao , Zhang Hui 
Published: June 2024

Abstract
China’s secondary vocational medical education is essential for training primary health care personnel and enhancing public health responses. This education system currently faces challenges, primarily due to its emphasis on knowledge acquisition that overshadows the development and application of skills, especially in the context of emerging artificial intelligence (AI) technologies. This article delves into the impact of AI on medical practices and uses this analysis to suggest reforms for the vocational medical education system in China. AI is found to significantly enhance diagnostic capabilities, therapeutic decision-making, and patient management. However, it also brings about concerns such as potential job losses and necessitates the adaptation of medical professionals to new technologies. Proposed reforms include a greater focus on critical thinking, hands-on experiences, skill development, medical ethics, and integrating humanities and AI into the curriculum. These reforms require ongoing evaluation and sustained research to effectively prepare medical students for future challenges in the field.
KRITIK TERHADAP PERPU DI MASA PANDEMI: PEMBATASAN HAK TANPA KEDARURATAN
Authors: Nalle Victor Imanuel W. 
Published: June 2024

Abstract
After establishing a public health emergency with Presidential Decree No.11 of 2020, President Joko Widodo issued a Government Regulation in Lieu of Law No. 1 of 2020 (Perppu No.1 of 2020). Perppu No. 1 of 2020 was like becoming emergency legislation by suspending the right to examine government administration decisions. This article criticizes the arguments that place Perppu No. 1 of 2020 as emergency legislation which then allows the violation of the rule of law or suspends the rights of citizens. This article uses the comparative law method by examining the concept of fast-track legislation in the UK and Ecuador and comparing it to the concept of emergency legislation as a basis for criticism of the Perppu no. 1 of 2020. This criticism is carried out from the perspective of both emergency legislation and fast-track legislation. This article shows that the Perppu No. 1 of 2020 should be classified as limited as fast track legislation that cannot suspending citizens’ rights.

Intisari
Setelah menetapkan darurat kesehatan masyarakat dengan Keputusan Presiden Nomor 11 Tahun 2020, Presiden Joko Widodo menetapkan Peraturan Pemerintah Pengganti Undang-Undang No. 1 Tahun 2020 (Perppu No. 1 Tahun 2020). Perppu No. 1 Tahun 2020 seolah-olah menjadi legislasi darurat dengan menangguhkan hak untuk menguji keputusan administrasi pemerintahan. Artikel ini mengkritik argumen yang menempatkan Perppu No. 1 Tahun 2020 sebagai legislasi darurat yang kemudian memungkinkan penyimpangan aturan hukum atau menangguhkan hak warga negara. Artikel ini menggunakan metode perbandingan hukum dengan mengkaji konsep legislasi jalur cepat di Inggris dan Ekuador dan membandingkannya dengan konsep legislasi darurat sebagai dasar kritik bagi konsep Perppu No. 1 Tahun 2020. Artikel ini menunjukkan bahwa Perppu No. 1 Tahun 2020 seharusnya diklasifikasikan sebatas sebagai legislasi jalur cepat yang tidak dapat menangguhkan hak warga negara.
MENAFSIRKAN PANCASILA: WEWENANG PEMERINTAH ATAU PERAN WARGA NEGARA? SUATU TELAAH DARI PERSPEKTIF HERMENEUTIKA KRITIS HABERMASIAN
Authors: Cornelius Conrado M. 
Published: June 2024

ABSTRACT
This article aims at offering an ideal theory of interpreting Pancasila as a state ideology in a context of a democratic society. This essay is arguing against the notion that Pancasila should be interpreted by the Government. In doing so, the author examines the merits of such notion from a legal and philosophical standpoint. The former focuses exclusively on the question of legality, whereas the latter on hermeneutics. This article offers an alternative theory of interpreting Pancasila that is built on a Habermasian Critical Hermeneutics. This article argues that any interpretation on ideology—including Pancasila—should be situated in a deliberative democracy that is directed at emancipating the interpreter, that is the People of Indonesia. At the end of this article, this Article concludes that not only such an interpretation is made possible by law, but it is also philosophically justified.
Abstrak
Tulisan ini bertujuan untuk menawarkan sebuah teori yang ideal untuk menafsirkan Pancasila sebagai sebuah ideologi negara. Tulisan ini berpendapat bahwa Pancasila tidak dapat ditafsirkan oleh Pemerintah. Untuk mencapai kepada kesimpulan tersebut, tulisan ini menyajikan suatu diskusi dari dua macam sudut pandang, yakni dari perspektif hukum dan filsafat. Dari perspektif hukum, fokus utama diarahkan pada permasalahan legalitas, sedangkan perspektif filsafat memiliki fokus pada hermeneutika. Berdasarkan dua macam perspektif tersebut, tulisan ini mengajukan sebuah alternatif penafsiran atas Pancasila yang didasarkan pada Hermeneutika Kritis Habermasian. Tulisan ini berpendapat, bertolak dari perspektif Hermeneutika Kritis Habermasian, bahwa segala bentuk penafsiran terhadap ideologi—karenanya juga Pancasila—harus ditempatkan dalam situasi demokrasi yang deliberatif yang bertujuan untuk mengemansipasi penafsirnya, yakni masyarakat Indonesia. Kesimpulan dari tulisan ini adalah bahwa penafsiran Pancasila oleh masyarakat Indonesia tidak hanya dimungkinkan secara hukum, tetapi juga dibenarkan secara filosofis.
A prospective study on maternal periodontal diseases and neonatal adverse outcomes
Authors: Wen Ping , Li Huijun , Xu Xiaoyi , Zhang Feng , Zhao Dan , Yu Rong , Cheng Tianfan , Wang Hao , Yang Chuanzhong , Qin Wei , Yang Xiuqiao , Yao Jilong , Jin Lijian 
Published: June 2024

Objective: It is evident that periodontitis is linked to various adverse pregnancy outcomes. This prospective study explored the potential link of maternal periodontal diseases to neonatal adverse outcomes.
Materials and Methods: A total of 193 generally healthy females in their third trimester (34–36 weeks) of pregnancy were enrolled. All subjects received full-mouth periodontal assessment, and the periodontal inflamed surface area (PISA) was calculated. Demographic data, lifestyles and anthropometric measurements of the neonates (e.g., body length and head circumference) were recorded. Herein, small-for-gestational age (SGA) referred to gender- and age-adjusted birth weight below the 10th percentile in line with the standard reference. Multivariable logistic regression analysis and restricted cubic spline were performed for examining the association of periodontal parameters with SGA.
Results: There were 8.3% (16/193) of neonates with SGA. Significantly positive correlation existed between the percentage of tooth sites with increased probing depth and an elevated risk of SGA (OR: 1.052; P < 0.05). Yet, the PISA was positively associated with the risk of SGA (OR: 1.002; P < 0.05) as well. No significant link occurred between maternal periodontal status and other neonatal outcome measures.
Conclusion: Within the limitations of this study, the findings suggest that there could be a link between maternal periodontal diseases and neonatal adverse outcomes like SGA. Further investigation is required to clarify the current findings and potential implications for promoting maternal oral/periodontal health and newborn health.
Copson-type Inequalities via the k-Hadamard Operator
Authors: Benaissa Bouharket , Azzouz Noureddine 
Published: June 2024

Abstract
In this paper, we present a novel class of Copson-type inequalities involving the right-sided k-Hadamard fractional integral operator with all parameters of integrability p ≠ 0 and obtain some classical special cases of Copson inequalities. The main results will be proved by employing the Hölder inequality and the Fubini theorem.
Community engagement in waste reduction: A critical component for Gunung Sewu Geopark conservation, Yogyakarta, Indonesia
Authors: Masjhoer Jussac Maulana , Vitrianto Primantoro Nur 
Published: June 2024

Abstract
The key to achieving an effective and sustainable geopark waste management system is fostering community participation. This research about the Gunung Sewu Geopark, Yogyakarta, Indonesia, examines the phases and levels of community participation in waste reduction. The study involved surveying 1,757 respondents aged 18 and above using door-to-door questionnaires, which were analysed using the conditional probability method to determine participation stages and levels. The results indicate that community participation in waste reduction activities, such as composting and recycling is inadequate, with only 21.12% of respondents participating in the decision-making stage, 1.99% participating in the implementation stage, and 0.68% finding waste reduction activities valuable. Rural community participation level scores were 0.68 and categorised as very low. The incomplete stages of participation and low levels of participation are significant challenges for implementing sustainable waste management and maintaining conservation principles in Gunung Sewu Geopark. Further research could be conducted to determine the driving factors that most influence rural community participation so that geopark policymakers can develop strategies to increase participation more effectively and to targets.