bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnostic role of p16/INK4A protein in Human Papillomavirus (HPV) induced cervical dysplasia
Authors: Rajčáni Július , Adamkov Marián , Hybenova Jana , Jackuliak Jaroslav , Benčat Marian 
Published: June 2010

Abstract
The p16/INK4A protein is a cellular regulatory polypeptide over-expressed in the presence of high levels of the Human Papillomavirus (HPV) coded E7 protein. This review outlines the use of p16 antigen staining in cervical biopsies as well as in PAP smears summarizing the corresponding literature and commenting the authors’ own experience. The p16 antigen is a reliable marker for dysplastic cells in CINII/CINIII (HSIL) lesions as viewed in cervical biopsies. When PAP smears were examined at large scale screening for p16 antigenreactive and atypical cells, considerable variations could be found especially in ASCUS graded lesions. Therefore, the presence of p16-reactive atypical cells in PAP smears should be interpreted together with the cytological signs of dysplasia, such as the altered N/C ratio. In addition, women revealing p16-positive ASCUS/LSIL specimens should be examined for the presence of HPV DNA. Detection of HPV DNA alone, i.e. in the absence of cytological screening has a low predictive value, since the clearance of HPV may occur even in the absence of morphological alterations. Combined cytological as well as molecular follow up contributes to the efficiency of diagnostic and increases the probability of correct interpretation of the pre-cancerous lesions by non-invasive techniques.
The gravity flow dynamics of submarine fan sedimentation in the Magura Basin of the Western Carpathians (Magura Nappe, Slovakia)
Authors: Teťák František 
Published: June 2010

The gravity flow dynamics of submarine fan sedimentation in the Magura Basin of the Western Carpathians (Magura Nappe, Slovakia)This article deals with the dynamics of the deep-water gravity flows sedimentation within the Magura Formation. This investigation is based on analysis of the Magura sandstone sedimentary structures studied on the outcrops. The final comparison of the sedimentary structures and cycles with the paleocurrent directions provided an interpretation of the gravity flows dynamics and helped to restore the migration of the sandy lobes in space and time. Three modes of sedimentation are recorded: regular cyclic sedimentation from the lobe, irregular sedimentation from the immature lobe and pelitic sedimentation on the basin plane without the lobe influence. We compared the occurrence of some sedimentary structures with the changes of the current directions and bed thickness. The following interpretations of gravity flow fan dynamics are results of this comparision: the fan consists of one or several lobes, the lobe branches out into branches with the radial current arrangement, the lobes laterally change position and the lobes suddenly die out.
Reconstruction of Cenozoic paleostress fields and revised tectonic history in the northern part of the Central Western Carpathians (the Spišská Magura and Východné Tatry Mountains)
Authors: Vojtko Rastislav , Tokárováá Eva , Sliva Ľubomír , Pešková Ivana 
Published: June 2010

Reconstruction of Cenozoic paleostress fields and revised tectonic history in the northern part of the Central Western Carpathians (the Spišská Magura and Východné Tatry Mountains)This study investigates the chronology of paleostress evolution and faulting in the northern part of the Central Western Carpathians (Spišská Magura and Východné Tatry Mts). Paleostress analysis of brittle and semibrittle structures of the Eocene-Oligocene succession of the Central Carpathian Paleogene Basin (CCPB) supplemented by measurements in the Triassic sequence of the Krížna Nappe, revealed the existence of six tectonic regimes during the Cenozoic. Orientation of the paleostress field before the deposition of the CCPB was characterized by the E-W oriented compression. After this compression, the paleostress field rotated approximately 40-50°, and NW-SE directed compression took place in the Early Miocene. During the latest Early Miocene, the extensional tectonic regime with fluctuation of σ3orientation between NW-SE to NE-SW dominated. The Late Badenian-Pannonian is characterized by a new compressive to strike-slip tectonic regime during which the principal maximum stress axis σ1progressively rotated from a NW-SE to a NE-SW position. Uplift and tilting of the Tatra Massif took place during this stage. The neotectonic stage (Pliocene to Holocene) is characterized by extensional tectonic regime with the two directions of tension. The first one is oriented in the E-W direction and could be considered older and the second one, NNW-SSE tension is considered to be Late Pliocene to Quaternary in age. In general, orientation of the stress fields shows an apparent clockwise rotation from the Oligocene to Quaternary times. This general clockwise rotation of the Oligocene to Quaternary paleostress fields could be explained by both the effect of the counter-clockwise rotation of the ALCAPA microplate and by the regional stress field changes.
Prospective surveillance of complications in a pediatric neurosurgery unit
Authors: Drake James M. , Riva-Cambrin Jay , Jea Andrew , Auguste Kurtis , Tamber Mandeep , Lamberti-Pasculli Maria 
Published: June 2010

Object
Complications of specific pediatric neurosurgical procedures are well recognized. However, focused surveillance on a specific neurosurgical unit, for all procedures, may lead to better understanding of the most important complications, and allow targeted strategies for quality improvement.

Methods
The authors prospectively recorded the morbidity and mortality events at a large pediatric neurosurgical unit over a 2-year period. Morbidity was defined as any significant adverse outcome or death (for obstructive shunt failure, within 30 days). Multiple and unrelated complications in the same patient were recorded as separate events.

Results
There were 1082 surgical procedures performed during the evaluation period. One hundred seventy-seven complications (16.4%) occurred in 147 patients. By procedure, the most common complications occurred in vascular surgery (41.7%) and brain tumor surgery (27.9%). The most common complications were CSF leakage (31 cases), a new neurological deficit (27 cases), early shunt or endoscopic third ventriculostomy obstruction (27 cases), and shunt infection (24 cases). Meningitis occurred in 19 cases: in 58% of shunt infections, 13% of CSF leaks, and 10% of wound infections. Sixty-four percent of adverse events required a second procedure, most commonly an external ventricular drain placement or shunt revision.

Conclusions
Complications in pediatric neurosurgical procedures are common, result in significant morbidity, and more than half the time require a repeat surgical procedure. Targeted strategies to prevent common complications, such as shunt infections or CSF leaks, might significantly reduce this burden.
Late obstruction of an endoscopic third ventriculostomy stoma by metastatic seeding of a recurrent medulloblastoma
Authors: Nigri Flávio , Telles Carlos , Acioly Marcus André 
Published: June 2010

Endoscopic third ventriculostomy (ETV) has been established as an effective method in the treatment of tumoral obstructive hydrocephalus. Delayed closure of the ETV stoma has been attributed to scarring involving the third ventricular floor. Secondary obstruction of the stoma due to intraventricular tumor seeding is an extremely rare condition, with only one case described to date. The authors report on a unique case of late closure of the ETV stoma caused by metastatic seeding of a recurrent medulloblastoma 9 years after the initial treatment. The patient was submitted to a second endoscopic procedure in which a reddish mass located just at the third ventricular floor was resected, leading to reopening of the previous ETV stoma.
To the best of the authors' knowledge, this case is the first report of an ETV obstruction due to metastatic CSF seeding of a medulloblastoma. In such cases of late failure of the ETV stoma because of tumor obstruction, a second ETV can be safely performed and lead to adequate function of the stoma, even if limited by the aggressive nature of the disease.
Prevalence and natural history of arachnoid cysts in children
Authors: Al-Holou Wajd N. , Yew Andrew Y. , Boomsaad Zackary E. , Garton Hugh J. L. , Muraszko Karin M. , Maher Cormac O. 
Published: June 2010

Object
Arachnoid cysts are a frequent finding on intracranial imaging in children. The prevalence and natural history of these cysts are not well defined. The authors studied a large consecutive series of children undergoing MR imaging to better define both the MR imaging–demonstrated prevalence and behavior of these lesions over time.

Methods
The authors reviewed a consecutive series of 11,738 patients who were 18 years of age or younger and had undergone brain MR imaging at a single institution during an 11-year period. In the patients in whom intracranial arachnoid cysts were identified, clinical and demographic information was recorded and imaging characteristics, such as cyst size and location, were evaluated. Prevalence data were analyzed using univariate and multivariate logistic regression, linear regression, and ANOVA. All patients with sufficient data (repeat MR imaging studies as well as repeated clinical evaluation over at least 5 months) for a natural history analysis were identified. This group was assessed for any change in symptoms or imaging appearance during the follow-up interval.

Results
Three hundred nine arachnoid cysts (2.6% prevalence rate) were identified. There was an increased prevalence of arachnoid cysts in males (p < 0.000001). One hundred eleven patients met all criteria for inclusion in the natural history analysis. After a mean follow-up of 3.5 years, 11 arachnoid cysts increased in size, 13 decreased, and 87 remained stable. A younger age at presentation was significantly associated with cyst enlargement (p = 0.001) and the need for surgery (p = 0.05). No patient older than 4 years of age at the time of initial diagnosis had cyst enlargement, demonstrated new symptoms, or underwent surgical treatment.

Conclusions
Arachnoid cysts are a common incidental finding on intracranial imaging in pediatric patients. An older age at the time of presentation is associated with a lack of clinical or imaging changes over time.
Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas
Authors: Phi Ji Hoon , Kim Jin Hyun , Eun Kyoung Mi , Wang Kyu-Chang , Park Ki Ho , Choi Seung Ah , Kim Young Yim , Park Sung-Hye , Cho Byung-Kyu , Kim Seung-Ki 
Published: June 2010

Object
Supratentorial primitive neuroectodermal tumor (PNET) and medulloblastoma are highly malignant embryonal brain tumors. They share morphological similarities, but differ in their differentiation patterns and global gene expression. The authors compared the expression of specific genes involved in neuroglial differentiation in supratentorial PNETs and medulloblastomas to define the distinct characters of these tumors.

Methods
The mRNA expression of 8 genes (SOX2, NOTCH1, ID1, ASCL-1, NEUROD1, NEUROG1, NEUROG2, and NRG1) was evaluated in 25 embryonal tumors (12 supratentorial PNETs and 13 medulloblastomas) by quantitative real-time polymerase chain reaction. The expression levels of the transcripts of these genes were compared between the tumor groups. Activation of the JAK/STAT3 pathway was assessed by immunoblotting. Relative expression levels of STAT3 and phosphorylated STAT3 proteins were compared.

Results
Supratentorial PNETs expressed significantly higher levels of SOX2, NOTCH1, ID1, and ASCL-1 transcripts, whereas the transcription of proneural basic helix-loop-helix factors, NEUROD1, NEUROG1 (significantly), and NEUROG2 (not significantly) was upregulated in medulloblastomas. The proportion of phosphorylated STAT3α relative to STAT3α was significantly greater in supratentorial PNETs than in medulloblastomas, indicating activation of the JAK/STAT3 pathway in supratentorial PNETs.

Conclusions
These results indicate that supratentorial PNET predominantly has glial features and medulloblastoma largely follows a neuronal differentiation pattern. These divergent differentiation patterns may be related to the location and origin of each tumor.
Use of ifosfamide, carboplatin, and etoposide chemotherapy in choroid plexus carcinoma
Authors: Lafay-Cousin Lucie , Mabbott Donald J. , Halliday William , Taylor Michael D. , Tabori Uri , Kamaly-Asl Ian D. , Kulkarni Abhaya V. , Bartels Ute , Greenberg Mark , Bouffet Eric 
Published: June 2010

Object
Choroid plexus carcinomas (CPCs) are rare pediatric tumors with a generally poor prognosis. Although the role of surgery is well recognized, the role of adjuvant chemotherapy and radiation therapy remains unclear. In this paper, the authors' goal was to assess the role of second-look surgery and neoadjuvant ifosfamide, carboplatin, etoposide (ICE) chemotherapy in the management of CPC and to study neurocognitive outcome.

Methods
The authors performed an institutional retrospective review of patients in whom CPC was diagnosed between 1985 and 2006 at the Hospital for Sick Children in Toronto. Fourteen patients (7 boys and 7 girls) were included. The median age at diagnosis was 18.6 months (range 1.1–65.3 months). Four patients had evidence of metastatic disease at diagnosis. Two of the 14 patients underwent gross-total resection during initial surgery; 12 of the patients received neoadjuvant chemotherapy, 10 of whom underwent second surgery. In total, of 12 patients who received chemotherapy with a curative intent, 11 underwent a greater than 95% resection. Neoadjuvant ICE chemotherapy was given prior to second surgery (median 4 cycles, range 2–5 cycles) and was continued after second resection for a median total of 7 cycles (range 4–16 cycles).

Results
No tumor progression was observed during chemotherapy prior to second surgery. Five patients subsequently experienced tumor progression/relapse. At a median follow-up of 6.9 years (range 1.9–18.5 years), 8 patients are alive. None of the survivors received radiation therapy. However, 6 of 8 display significant neurocognitive and/or sensorial deficit.

Conclusions
In this experience, second surgery following neoadjuvant ICE chemotherapy led to a high rate of complete or near-complete resection. Chemotherapy appears to facilitate second-look surgery, in particular through a reduction of intraoperative blood loss. Despite radiation avoidance, the majority of survivors experienced significant neurocognitive impairment.
Chiari malformation Type I in children younger than age 6 years: presentation and surgical outcome
Authors: Albert Gregory W. , Menezes Arnold H. , Hansen Daniel R. , Greenlee Jeremy D. W. , Weinstein Stuart L. 
Published: June 2010

Object
The authors conducted a study to evaluate the unique presenting signs and symptoms of Chiari malformation Type I (CM-I) in children younger than 6 years of age and highlight the benefits of early surgical treatment in this patient population.

Methods
The authors reviewed the medical records of patients who presented to the neurosurgery department before their 6th birthday and subsequently underwent surgery for CM-I. They identified 39 patients who had been evaluated between 1984 and 2007 and examined the medical records for presentation, surgical intervention, and outcome.

Results
Children aged 0–2 years commonly presented with oropharyngeal dysfunction (77.8%). Children aged 3–5 years more frequently presented with syringomyelia (85.7%), scoliosis (38.1%), and/or headache (57.1%). All patients underwent posterior fossa craniectomy. Additionally, in many patients cervical laminectomy and/or duraplasty was performed. A few patients required transoral decompression and occipitocervical fusion. In most cases, surgery led to resolution or dramatic improvement of initial symptoms.

Conclusions
Early recognition and surgical treatment of CM-I in young children leads to good outcomes in the majority of patients. Additional therapies for oropharyngeal dysfunction, syringomyelia, and scoliosis can frequently be avoided.
Epidemiology of brachial plexus injury in the pediatric multitrauma population in the United States
Authors: Dorsi Michael J. , Hsu Wesley , Belzberg Allan J. 
Published: June 2010

Object
The aim of this study was to estimate the prevalence of brachial plexus injury (BPI) in pediatric multitrauma patients.

Methods
The National Pediatric Trauma Registry was queried using the ICD-9 code 953.4, injury to brachial plexus, to identify cases of BPI. The patient demographics, mechanism of trauma, and associated ICD-9 diagnoses were analyzed.

Results
Brachial plexus injuries were identified in 113 (0.1%) of the 103,434 injured children entered in the registry between April 1, 1985, and March 31, 2002. Sixty-nine patients (61%) were male. Injuries were most often caused by motor vehicle accidents involving passengers (36 cases [32%]) or pedestrians (19 cases [17%]). Head injuries were diagnosed in 47% of children and included concussion in 27%, intracranial bleeds in 21%, and skull fractures in 14%. Upper-extremity vascular injury occurred in 16%. The most common musculoskeletal injuries were fractures of the humerus (16%), ribs (16%), clavicle (13%), and scapula (11%). Spinal fractures occurred in 12% of patients, and spinal cord injury occurred in 4%. The Injury Severity Score ranged from 1 to 75, with a mean score of 10, and 6 patients (5%) died as a result of injuries sustained during a traumatic event.

Conclusions
Brachial plexus injuries occur in 0.1% of pediatric multitrauma patients. Motor vehicle accidents and pedestrians struck by a motor vehicle are the most common reasons for BPIs in this population. Common associated injuries include head injuries, upper-extremity vascular injuries, and fractures of the spine, humerus, ribs, scapula, and clavicle.
Climatogenic north–south asymmetry of local glaciers in Spitsbergen and other parts of the Arctic
Authors: Evans Ian S. , Cox Nicholas J. 
Published: June 2010

AbstractAlthough World Glacier Inventory (WGI) data for 241 local glaciers (>1 km2 in area) in Svalbard show a mean aspect of 014˚ ± 24˚, their mid-altitudes are lowest for an aspect of 109˚ ± 46˚, which is inconsistent. Further data are generated here for the altitude, length and source aspect of 205 local glaciers (0.3–6.0 km long) in the main area of local glaciation in Svalbard, Nordenskiöld Land. All four mountain blocks have mean glacier source aspects of 356˚ to 018˚; the overall mean is 011˚ ± 8˚. Mid-altitudes are lowest at 042˚ ±21˚, predicted to be 53 m lower than on opposite aspects. Lowest altitudes are predicted at 009˚ to 030˚, averaging 157 m lower than on opposite aspects. These results show that local, land-terminating glaciers around 78˚ N are affected more by north-south radiation receipt contrasts than by wind effects, consistent with the trend found across most other Arctic regions. It is concluded that, although weaker than in mid-latitudes, contrasts due to slope climates are substantial even in Arctic glaciers. This is apparent only when small, steep glaciers are inventoried: WGI data are incomplete and users need to check the thresholds of coverage.
Geometry and thermal regime of the King George Island ice cap, Antarctica, from GPR and GPS
Authors: Blindow Norbert , Suckro Sonja K. , Rückamp Martin , Braun Matthias , Schindler Marion , Breuer Birgit , Saurer Helmut , Simões Jefferson C. , Lange Manfred A. 
Published: June 2010

AbstractKing George Island is the largest of the South Shetland Islands, close to the tip of the Antarctic Peninsula. The annual mean temperature on the island has increased by 1°C during the past three decades, and the ice cap that covers the majority of the island is sensitive to climatic change. We present data from two field campaigns (1997 and 2007): 700 km of global positioning system (GPS) and ground-penetrating radar (GPR) profiles were collected on Arctowski Icefield and on the adjacent central part. The data were analysed to determine the surface and bed topography and the thermal regime of the ice. Average ice thickness is 250 m and maximum thickness is 420 m. The GPR profiles show isochrones throughout the ice cap which depict the uparching of Raymond bumps beneath or close to the ice divides. A water table from percolation of meltwater in the snowpack shows the firn-ice boundary at ∼ 3 5 m depth. The firn layer may be temperate due to the release of latent heat. In the area below 400ma.s.l., backscatter by water inclusions is abundant for ice depths below the water table. We interpret this as evidence for temperate ice. Scatter decreases significantly above 400 m. Ice temperatures below the water table in this part of the ice cap are subject to further field and modelling investigations.
Deformation and failure of the ice bridge on the Wilkins Ice Shelf, Antarctica
Authors: Humbert A. , Gross D. , Müller R. , Braun M. , van de Wal R.S.W. , van den Broeke M.R. , Vaughan D.G. , van de Berg W.J. 
Published: June 2010

AbstractA narrow bridge of floating ice that connected the Wilkins Ice Shelf, Antarctica, to two confining islands eventually collapsed in early April 2009. In the month preceding the collapse, we observed deformation of the ice bridge by means of satellite imagery and from an in situ GPS station. TerraSAR-X images (acquired in stripmap mode) were used to compile a time series. The ice bridge bent most strongly in its narrowest part (westerly), while the northern end (near Charcot Island) shifted in a northeasterly direction. In the south, the ice bridge experienced compressive strain parallel to its long axis. GPS position data were acquired a little south of the narrowest part of the ice bridge from 19 January 2009. Analysis of these data showed both cyclic and monotonic components of motion. Meteorological data and re-analysis of the output of weather-prediction models indicated that easterly winds were responsible for the cyclic motion component. In particular, wind stress on the rough ice melange that occupied the area to the east exerted significant pressure on the ice bridge. The collapse of the ice bridge began with crack formation in the southern section parallel to the long axis of the ice bridge and led to shattering of the southern part. Ultimately, the narrowest part, only 900 m wide, ruptured. The formation of many small icebergs released energy of >125 ×106 J.
Dielectric permittivity of snow measured along the route traversed in the Japanese–Swedish Antarctic Expedition 2007/08
Authors: Sugiyama Shin , Enomoto Hiroyuki , Fujita Shuji , Fukui Kotaro , Nakazawa Fumio , Holmlund Per 
Published: June 2010

AbstractAs a joint contribution of Japan and Sweden to the International Polar Year 2007–09, a field expedition between Syowa and Wasa stations in East Antarctica was carried out in the 2007/08 austral summer season. Along the 2800 km long expedition route, the dielectric permittivity of the upper 1 m snow layer was measured at intervals of approximately 50 km using a snow fork, a parallel-wire transmission-line resonator. More than 2000 measurements were performed under carefully calibrated conditions, mostly in the interior of Antarctica. The permittivity ε′ was a function of snow density as in previous studies on dry snow, but the values were significantly smaller than those reported before. In the light of the dielectric mixture theory, the relatively smaller ε′ obtained in this study can be attributed to the snow structures characteristic in the studied region. Our data suggest that the permittivity of snow in the Antarctic interior is significantly affected by weak bonding between snow grains, which is due to depth-hoar formation in the extremely low-temperature conditions.