bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of social and emotional support on serious psychological distress among people with functional disabilities and type 2 diabetes
Authors: Huang Ya-Ching , Bhattarai Muna , Cho Emma , Yoon Hyunwoo 
Published: May 2024

Objectives To examine the impact of social and emotional support on serious psychological distress (SPD) in individuals with type 2 diabetes (T2DM) and functional disabilities after controlling for socio-demographic factors and health status. Findings provide information for healthcare providers to enhance patients’ psychological well-being. Methods Data from 529 adults were obtained from the 2021 National Health Interview Survey, including those who had T2DM and also reported significant difficulty or inability to perform an activity in any of the following domains: seeing, hearing, walking or climbing stairs, communicating, remembering or concentrating, or practicing self-care. Descriptive analysis and a hierarchical regression model of SPD were used. Results The mean age of participants was 67.88 years old, and the mean duration of diabetes diagnosis was 16.88 years. Notably, 12.5% of individuals reported SPD. A decreased likelihood of reporting SPD occurrence was associated with older age (odds ratio (OR) = 0.95), a longer duration of T2DM diagnosis (OR = 0.97), having at least a high school education (OR = 0.54), and receiving social and emotional support. Discussion Social and emotional support likely mitigates psychological distress, suggesting that social and emotional support resources should be enhanced, especially among individuals who are younger and those more recently diagnosed with T2DM.
A machine learning-based model for “In-time” prediction of periprosthetic joint infection
Authors: Chen Weishen , Hu Xuantao , Gu Chen , Zhang Zhaohui , Zheng Linli , Pan Baiqi , Wu Xiaoyu , Sun Wei , Sheng Puyi 
Published: May 2024

Background Previous criteria had limited value in early diagnosis of periprosthetic joint infection (PJI). Here, we constructed a novel machine learning (ML)-derived, “in-time” diagnostic system for PJI and proved its validity. Methods We filtered “in-time” diagnostic indicators reported in the literature based on our continuous retrospective cohort of PJI and aseptic prosthetic loosening patients. With the indicators, we developed a two-level ML model with six base learners including Elastic Net, Linear Support Vector Machine, Kernel Support Vector Machine, Extra Trees, Light Gradient Boosting Machine and Multilayer Perceptron), and one meta-learner, Ensemble Learning of Weighted Voting. The prediction performance of this model was compared with those of previous diagnostic criteria (International Consensus Meeting in 2018 (ICM 2018), etc.). Another prospective cohort was used for internal validation. Based on our ML model, a user-friendly web tool was developed for swift PJI diagnosis in clinical practice. Results A total of 254 patients (199 for development and 55 for validation cohort) were included in this study with 38.2% of them diagnosed as PJI. We included 21 widely accessible features including imaging indicators (X-ray and CT) in the model. The sensitivity and accuracy of our ML model were significantly higher than ICM 2018 in development cohort (90.6% vs. 76.1%, P = 0.032; 94.5% vs. 86.7%, P = 0.020), which was supported by internal validation cohort (84.2% vs. 78.6%; 94.6% vs. 81.8%). Conclusions Our novel ML-derived PJI “in-time” diagnostic system demonstrated significantly improved diagnostic potency for surgical decision-making compared with the commonly used criteria. Moreover, our web-based tool greatly assisted surgeons in distinguishing PJI patients comprehensively. Level of evidence Diagnostic Level III.
Heuristics used for evaluating the usability of mobile health applications: A systematic literature review
Authors: Galavi Zahra , Norouzi Somaye , Khajouei Reza 
Published: May 2024

Objective Mobile health applications hold immense potential for enhancing health outcomes. Usability is one of the main factors for the adoption and use of mobile health applications. However, despite the growing importance of mHealth applications, clear standards for their evaluation remain elusive. The present study aimed to determine heuristics for the usability evaluation of health-related applications. Methods We systematically searched multiple databases for relevant papers published between January 2008 and April 2021. Articles were reviewed, and data were extracted and categorized from those meeting inclusion criteria by two authors independently. Heuristics were identified based on statements, words, and concepts expressed in the studies. These heuristics were first mapped to Nielsen's heuristics based on their differences or similarities. The remaining heuristics that were very important for mobile applications were categorized into new heuristics. Results Seventeen studies met the eligibility criteria. Seventy-nine heuristics were extracted from the papers. After combining the items with the same concepts and removing irrelevant items based on the exclusion criteria, 20 heuristics remained. Common heuristics such as “Visibility of system status” and “Flexibility and efficiency of use” were categorized into 10 previously established heuristics and new heuristics like “Navigation” and “User engagement” were recognized as new ones. Conclusions In our study, we have meticulously identified 20 heuristics that hold promise for evaluating and designing mHealth applications. These heuristics can be used by the researchers for the development of robust tools for heuristic evaluation. These tools, when adapted or tailored for health domain applications, have the potential to significantly enhance the quality of mHealth applications. Ultimately, this improvement in quality translates to enhanced patient safety. Protocol Registration (10.17605/OSF.IO/PZJ7H)
Application of a WeChat Mini Program to provide pharmaceutical care for cancer pain patients: A randomized controlled trial
Authors: Zhao Qiuling , Qiu Xiuliang , Liu Wenbin , Nian Zilin , Chen Ting , Chen Juan , Xie Ruixiang , Yang Lin 
Published: May 2024

Objective This study aimed to develop an individual WeChat Mini Program to provide pharmaceutical care to better manage cancer pain patients and to evaluate its feasibility and the differences in analgesic efficacy, medication adherence and safety versus conventional pharmacy interventions. Methods In this parallel randomized clinical trial, 42 cancer pain patients were equally allocated into the experimental group and the control group. The experimental group received individualized pharmaceutical care based on the “Yao Nin You Wo” WeChat Mini Program, while the control group received conventional care during the 4-week period. Main outcomes contained pain scores, medication adherence, incidences and relief rates of breakthrough pain, and incidences of adverse events. Relief rates of pain were also calculated according to pain scores. Results At the beginning of intervention, none of the pain scores and medication adherence showed relevant differences between the two groups (all P > .05). After intervention, the experimental group had significantly lower pain scores compared to the control group ( P = .003). Breakthrough pain of both groups was alleviate; not only the incidence of breakthrough pain considerably was lower at 4 weeks than at baseline, but the relief rate of breakthrough in the experimental group was higher than that in the control group. Compared with the control group, the medication adherence rate of the experimental group was significantly improved ( P = .02). Types of adverse events that happened in experimental and groups were similar, but the total incidence of adverse events in the experimental group was lower than that in the control group. Conclusions WeChat Mini Program is a useful and facilitative tool with the potential to improve cancer pain self-management ability in discharged patients. In addition, pharmacists could play a key role through the Mini Program to connect with patients successfully by providing personalized pharmaceutical services.
Would you date a liar? The impact of greenwashing on B2B relationships under the managerial trust view
Authors: Valero-Gil Jesus , Suárez-Perales Inés , Ferrón-Vílchez Vera 
Published: May 2024

Greenwashing can be perceived as dishonest behavior that can threaten trust in business deals due to the current trend of an intensive scrutiny of sustainability-related messages from organizations. Drawing on the literature concerning managerial trust, our study analyzes how perceived greenwashing negatively affects business-to-business relationships, focusing on two aspects: (1) whether managers’ perception of greenwashing is influenced by uncertainty in the business decision-making process and (2) whether individual manager characteristics play a significant role in modulating this influence. We used an experimental design involving 125 Spanish managers to confirm the importance of uncertain scenarios under the negative influence of greenwashing on business decision-making process. The findings also confirm that this negative influence is intensified by managers’ characteristics in terms of risk aversion and the importance they place on corporate reputation. The study makes several contributions to academia and practitioners by advancing the understanding of greenwashing in the context of business-to-business relationships. JEL CLASSIFICATION: M100; M140; M210
Exploring nurses’ postturnover experiences in their new employment: A self-determination and job-fit perspective
Authors: Bolt Ester Ellen Trees , Cafferkey Kenneth , Townsend Keith , van der Cingel Margreet 
Published: May 2024

Nurses are known for having to work in a demanding work environment. As a result of this, nurses often quit their job, hoping to get better working conditions elsewhere. In this wave of change, how do nurses experience postturnover re-employment? Based on self-determination and person-job fit theory, this article aims to explore the postturnover experiences of nurses working in Dutch health care. 56 interviews were conducted where nurses reflected upon experiences at their former and current employment. Three main themes were identified: (1) improved levels of mental and physical well-being, (2) alignment of job skills and job needs to work environment, and (3) enhanced professional network. Our findings are congruent with self-determination theory and person-job fit theory and extend the knowledge base on individual postturnover implications, highlighting that turnover, although often seen as a negative phenomenon from the perspective of an organization, can benefit those who change employers. JEL CLASSIFICATION: M100
Patient and family engagement in patient safety practices: A Making Healthcare Safer rapid response review
Authors: Dukhanin Vadim , Dy Sydney M. , Sharma Ritu , Vass Montrell , Zhang Allen , Bass Eric B. , Rosen Michael 
Published: May 2024

Background Patient and family engagement (PFE) is a developing area in reducing patient harm. This review addresses two questions: 1) What PFE patient safety practices (PSPs) have been used to prevent, report, or mitigate harms to patients and in what settings have they been used? 2) What evidence of effectiveness and unintended effects of PFE PSPs has been published since the Making Healthcare Safer (MHS) III report? Methods We searched PubMed and the Cochrane Library for studies published between January 2019 and April 2023. We included reviews of and primary studies on safety, quality, or utilization outcomes associated with any intervention focused on PFE in reporting and/or reducing patient safety events and harms. Results We retrieved 768 citations and found one systematic review and five studies meeting the inclusion criteria. The studies were either multi-component patient fall interventions or patient portals and information tools. Patient fall intervention PFE PSPs demonstrated significant decreases in overall rate of fall (15%–71% reductions) and fall with injury (34%–67% reductions) across three studies and a 17% decrease in the hospital length of stay in one study. Across three studies employing portals and information tools, PFE PSPs facilitated the identification of errors and significantly decreased the hospital length of stay and readmissions. Conclusions Research on PFE PSPs provides emerging evidence of the effectiveness of including PFE as a component of interventions targeting specific preventable harms. More research is needed to support the measurement of and better determine the overall effectiveness of a broader implementation of PFE PSPs.
Self-Care of Diabetes and Diabetes Distress in Non-Hispanic Black Adults With Type 2 Diabetes
Authors: Neblett Debra A. , McCoy Thomas P. , Kennedy-Malone Laurie , Wallace Debra C. , Morrison Sharon D. 
Published: May 2024

Purpose: The purpose of the study was to describe the level of self-care of diabetes and diabetes distress and examine their relationship in non-Hispanic Black adults living with type 2 diabetes. Methods: This cross-sectional, correlational study was conducted with 275 non-Hispanic Black adults with type 2 diabetes in North Carolina over 10 weeks, July 2022 to September 2022. An online survey collected sociodemographic and clinical characteristics, self-care measures of diabetes, and diabetes distress. The theory of self-care of chronic illness guided the study. Median regression examined the relationship between self-care of diabetes and diabetes distress. Results: Of the 275 participants, over half reported a diagnosis of type 2 diabetes at younger ages than expected, with a mean age of 40. The self-reported mean A1C of 9% exceeded the recommended goal of <7%, with an average of 2 diabetes-related comorbidities. The self-care of diabetes scale scores were low, and total diabetes distress scores were high. Significant positive associations were found between total diabetes distress and self-care monitoring and self-care management. Conclusions: In this sample, non-Hispanic Black adults had low levels of self-care of diabetes and high levels of diabetes distress. The findings indicate a relationship between self-care of diabetes and diabetes distress; as diabetes distress increases, so do the attempted activities of self-care of diabetes. Health care professionals in diabetes care are uniquely positioned to address further the behavioral aspects of diabetes management, particularly diabetes distress, to support non-Hispanic Black adults living with type 2 diabetes.
Development and validation of a code-based algorithm using in-hospital medical records to identify patients with pulmonary arterial hypertension in a French healthcare database
Authors: Jambon-Barbara Clément , Hlavaty Alex , Bernardeau Claire , Bouvaist Hélène , Chaumais Marie-Camille , Humbert Marc , Montani David , Cracowski Jean-Luc , Khouri Charles 
Published: May 2024

IntroductionPulmonary arterial hypertension (PAH) is a rare and severe disease for which most of the evidence about prognostic factors, evolution and treatment efficacy comes from cohorts, registries and clinical trials. We therefore aimed to develop and validate a new PAH identification algorithm that can be used in the French healthcare database “Système National des Données de Santé (SNDS)”.MethodsWe developed and validated the algorithm using the Grenoble Alpes University Hospital medical charts. We first identified PAH patients following a previously validated algorithm, using in-hospital ICD-10 (10th revision of the International Statistical Classification of Diseases) codes, right heart catheterisation procedure and PAH-specific treatment dispensing. Then, we refined the latter with the exclusion of chronic thromboembolic pulmonary hypertension procedures and treatment, the main misclassification factor. Second, we validated this algorithm using a gold standard review of in-hospital medical charts and calculated sensitivity, specificity, positive and negative predictive value (PPV and NPV) and accuracy. Finally, we applied this algorithm in the French healthcare database and described the characteristics of the identified patients.ResultsIn the Grenoble University Hospital, we identified 252 unique patients meeting all the algorithm's criteria between 1 January 2010 and 30 June 2022, and reviewed all medical records. The sensitivity, specificity, PPV, NPV and accuracy were 91.0%, 74.3%, 67.9%, 93.3% and 80.6%, respectively. Application of this algorithm to the SNDS yielded the identification of 9931 patients with consistent characteristics compared to PAH registries.ConclusionOverall, we propose a new PAH identification algorithm developed and adapted to the French specificities that can be used in future studies using the French healthcare database.
Efficacy of surveillance bronchoscopyversusclinically indicated bronchoscopy for detection of acute lung transplant rejection: a systematic review and meta-analysis
Authors: Fricke Kai , Sievi Noriane Andrina , Schmidt Felix Peter , Schuurmans Macé Matthew , Kohler Malcolm 
Published: May 2024

BackgroundAcute allograft rejection after lung transplantation significantly increases the risk of developing bronchiolitis obliterans syndrome, a form of chronic lung allograft dysfunction and the leading cause of mortality beyond the initial post-transplantation year. There are two diagnostic approaches available for monitoring lung transplant recipients: clinically indicated bronchoscopy (CIB) and surveillance bronchoscopy (SB). The efficacy of both methods and their relative superiority in detecting acute rejection have not been conclusively determined.MethodsWe systematically searched the MEDLINE, Embase, Cochrane and Scopus databases from inception until 10 October 2023 for prospective studies comparing the efficacy of SB and CIB. Meta-analysis using a random effects model was performed for three observational cohort studies, totalling 122 patients with 527 bronchoscopies.ResultsOverall, neither SB nor CIB had a higher likelihood of detecting acute lung transplant rejection of any grade. Subsequent subgroup analyses showed no advantage for SB in detecting minimal rejection (grade A1), but an inverse association was observed for higher-grade rejection.ConclusionIn conclusion, our study found no significant difference in detecting acute lung transplant rejection between SB and CIB. However, due to the limited number of studies and small sample sizes, larger prospective studies are urgently needed to definitely determine whether there truly exists no difference between SB and CIB in detecting acute rejection, particularly A1 minimal rejection.
The effect of the COVID-19 pandemic on pediatric emergency department utilization in three regions in Switzerland
Authors: von Rhein Michael , Chaouch Aziz , Oros Vivian , Manzano Sergio , Gualco Gianluca , Sidler Marc , Laasner Ursula , Dey Michelle , Dratva Julia , Seiler Michelle ,   on behalf of the PedCov consortium, Altwicker-Hámori Szilvia , Volken Thomas , Wieber Frank 
Published: May 2024

Abstract
Purpose
The COVID-19 pandemic was associated with a decrease in emergency department (ED) visits. However, contradictory, and sparse data regarding children could not yet answer the question, how pediatric ED utilization evolved throughout the pandemic. Our objectives were to investigate the impact of the pandemic in three language regions of Switzerland by analyzing trends over time, describe regional differences, and address implications for future healthcare.

Methods
We conducted a retrospective, longitudinal cohort study at three Swiss tertiary pediatric EDs (March 1st, 2018—February 28th, 2022), analyzing the numbers of ED visits (including patients` age, triage categories, and urgent vs. non-urgent cases). The impact of COVID-19 related non-pharmaceutical interventions (NPIs) on pediatric ED utilization was assessed by interrupted time series (ITS) modelling.

Results
Based on 304′438 ED visits, we found a drop of nearly 50% at the onset of NPIs, followed by a gradual recovery. This primarily affected children 0–4 years, and both non-urgent and urgent cases. However, the decline in urgent visits appeared to be more pronounced in two centers compared to a third, where also hospitalization rates did not decrease significantly during the pandemic. A subgroup analysis showed a significant decrease in respiratory and gastrointestinal diseases, and an increase in the proportion of trauma patients during the pandemic.

Conclusions
The COVID-19 pandemic had substantial effects on number and reasons for pediatric ED visits, particularly among children 0–4 years. Despite equal regulatory conditions, the utilization dynamics varied markedly between the three regions, highlighting the multifactorial modification of pediatric ED utilization during the pandemic. Furthermore, future policy decisions should take regional differences into account.
Increasing the diagnostic yield of childhood glaucoma cases recruited into the 100,000 Genomes Project
Authors: Al-Saei Omayma , Malka Samantha , Owen Nicholas , Aliyev Elbay , Vempalli Fazulur Rehaman , Ocieczek Paulina , Al-Khathlan Bashayer ,   Genomics England Research Consortium, Fakhro Khalid , Moosajee Mariya 
Published: May 2024

AbstractChildhood glaucoma (CG) encompasses a heterogeneous group of genetic eye disorders that is responsible for approximately 5% of childhood blindness worldwide. Understanding the molecular aetiology is key to improving diagnosis, prognosis and unlocking the potential for optimising clinical management. In this study, we investigated 86 CG cases from 78 unrelated families of diverse ethnic backgrounds, recruited into the Genomics England 100,000 Genomes Project (GE100KGP) rare disease cohort, to improve the genetic diagnostic yield. Using the Genomics England/Genomic Medicine Centres (GE/GMC) diagnostic pipeline, 13 unrelated families were solved (13/78, 17%). Further interrogation using an expanded gene panel yielded a molecular diagnosis in 7 more unrelated families (7/78, 9%). This analysis effectively raises the total number of solved CG families in the GE100KGP to 26% (20/78 families). Twenty-five percent (5/20) of the solved families had primary congenital glaucoma (PCG), while 75% (15/20) had secondary CG; 53% of this group had non-acquired ocular anomalies (including iris hypoplasia, megalocornea, ectopia pupillae, retinal dystrophy, and refractive errors) and 47% had non-acquired systemic diseases such as cardiac abnormalities, hearing impairment, and developmental delay. CYP1B1 was the most frequently implicated gene, accounting for 55% (11/20) of the solved families. We identified two novel likely pathogenic variants in the TEK gene, in addition to one novel pathogenic copy number variant (CNV) in FOXC1. Variants that passed undetected in the GE100KGP diagnostic pipeline were likely due to limitations of the tiering process, the use of smaller gene panels during analysis, and the prioritisation of coding SNVs and indels over larger structural variants, CNVs, and non-coding variants.