bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of long-term survival in dogs with high-grade multicentric lymphoma
Authors: Marconato Laura , Stefanello Damiano , Valenti Paola , Bonfanti Ugo , Comazzi Stefano , Roccabianca Paola , Caniatti Mario , Romanelli Giorgio , Massari Federico , Zini Eric 
Published: February 2011

Abstract
Objective—To determine factors predicting survival in dogs with high-grade multicentric lymphoma.
Design—Retrospective cohort study.
Animals—127 dogs with high-grade multicentric lymphoma evaluated at 4 veterinary hospitals from 2000 to 2009.
Procedures—Records were reviewed to identify dogs with completely staged high-grade multicentric lymphoma treated with chemotherapy. Data collected included signalment, history, hematologic findings, tumor characteristics, treatment, and outcome. Long-term survival was defined as surviving > 2 years after diagnosis. Variables were analyzed for associations with dogs living > 2 years.
Results—Among the 127 enrolled dogs, 13 (10%) survived > 2 years with a median survival time of 914 days (range, 740 to 2,058 days). Survival rates at 3, 4, and 5 years were 4%, 3%, and 1 %, respectively. At diagnosis, 11 of the 13 long-term survivors had a body weight ≥ 10 kg, PCV ≥ 35%, absence of ionized hypercalcemia, centroblastic lymphoma, immunophenotype B, absence of bone marrow involvement, and lymphoma stages I through IV and were not previously treated with corticosteroids. The same combination of factors was present in 26 of 114 (23%) dogs surviving ≤ 2 years, yielding a negative predictive value of 97.8% for long-term survivors. Four of the 6 long-term survivors that died during the study died of another cancer; 3 of them had osteosarcoma.
Conclusions and Clinical Relevance—Absence of the aforementioned combination of variables at diagnosis may help identify dogs with lymphoma that will not survive > 2 years. Other types of neoplasia, in particular osteosarcoma, may develop in long-term–surviving dogs.
Dominating and total dominating partitions in cubic graphs
Authors: Southey Justin , Henning Michael 
Published: February 2011

Abstract
In this paper, we continue the study of domination and total domination in cubic graphs. It is known [Henning M.A., Southey J., A note on graphs with disjoint dominating and total dominating sets, Ars Combin., 2008, 89, 159–162] that every cubic graph has a dominating set and a total dominating set which are disjoint. In this paper we show that every connected cubic graph on nvertices has a total dominating set whose complement contains a dominating set such that the cardinality of the total dominating set is at most (n+2)/2, and this bound is essentially best possible.
On the global stability of time delayed CNNs
Authors: Margaris Athanasios 
Published: February 2011

AbstractThe objective of this paper is the concise presentation of the most important and recent lemmas and theorems associated with the global asymptotic and exponential stability of the equilibrium point of time delayed cellular neural networks. For each theorem a short proof is given, so that the reader can understand its features and its relationships to other theorems. In the last section, the presented theorems are grouped according to their characteristics and the way they relate to one another, and some of them are demonstrated, in order to draw conclusions about their use.
Humanistic Paradigms of Education in the Postmodern Vision
Authors: Šarkan Martin , Nemec Rastislav 
Published: February 2011

Humanistic Paradigms of Education in the Postmodern Vision
This study portrays the present social trends of the educational system against the background of the transformation of the social institutions that emerge as a result of the general changes to the social paradigm. These transformations have a direct impact on questions over classical humanistic ideals and educational goals relating to the social perceptions of the status of educated people. The aim of this study is to discuss the conditio postmoderna in the education system following the Declaration of Bologna, especially emphasising the thinking of K. Liessmann and G. Lipovetsky. This study also indicates the paradoxical effects of the reform process and compares them with classical ideals of the educated.
Is Borderline Personality a Particularly Right Hemispheric Disorder? A Study of P3a Using Single Trial Analysis
Authors: Meares Russell , Schore Allan , Melkonian Dmitriy 
Published: February 2011

Objective: To test the hypothesis that borderline personality disorder is a manifestation of a particularly right hemispheric disturbance, involving deficient higher order inhibition, and to consider the therapeutic implications of the findings. Methods: A cohort of 17 medication free borderline patients were compared with 17 age and sex matched controls by means of a study of p3a, which reflects the activity of one of the two main generators of the P300 (P3) of the event-related-potential. P3b reflects the output of the other generator. P3a, an aspect of the attentional system, depends upon prefrontally connected neurocircuitry. P3b is underpinned by a particularly parietally connected neural system. Using an oddball paradigm, P3a was extracted from the responses to targets using a novel single trial analysis. Results: In borderline patients, over homologous electrode sites, p3a amplitudes, but not latencies, were significantly larger in the right hemisphere compared with the left. The differences were most marked fronto-centrally. No such difference was shown in the control subjects. P3a at right hemisphere sites was significantly larger in borderline compared with control patients. There was no significant difference between the groups for the left hemisphere sites. Conclusions: The abnormally large amplitudes of P3a at right hemisphere sites in borderline patients together with the failure of habituation of P3a, are consistent with deficient inhibitory activity. Discussion of the findings suggest that they may reflect impeded maturation of the fronto-medial processing systems which, it is argued, may be a consequence of the typical early environment of those with the borderline condition. This suggestion leads to a consideration of optimal therapeutic behaviour in this condition, in particular for ‘matching’ or ‘analogical’ responsiveness.
La responsabilité sociale de l'entreprise (RSE) comme discours ambigu
Authors: Pesqueux Yvon 
Published: February 2011

Résumé La responsabilité sociale de l’entreprise (RSE) peut être considérée comme un discours au sens plein du terme, c’est-à-dire venant créer les « éléments de réalité » allant dans le sens du discours, mais aussi comme « prison » des directions des grandes entreprises, prisonnières de ce discours dans une forme de circularité « contenu du discours – éléments de réalité produits par le discours ». Et pourtant, une importante littérature aussi bien professionnelle qu’académique s’est développée autour de la RSE, littérature principalement zélatrice du discours au nom des « éléments de réalité » produits. Ce texte est construit sur l’argumentation suivante : après avoir rappelé les contours de l’« évidence éthique » de la fin du 20 e siècle, « évidence éthique » fondatrice du discours de la RSE, les éléments saillants de l’idéologie du « moment libéral » seront présentés puis les contours de la RSE avant d’envisager la RSE comme un discours ambigu. Codes JEL : M1, M38, M59
Responsabilité sociale de l'entreprise, comité d'entreprise européen et négociation collective transnationale
Authors: Barreau Jocelyne , Arnal Juliette 
Published: February 2011

Résumé Les liens entre le mouvement de responsabilisation sociale de l’entreprise et l’instauration de comités d’entreprise européens (CEe) sont supposés étroits. Ces deux démarches ont en commun le passage par une négociation collective transnationale et la conclusion d’un accord cadre européen ou d’un accord cadre international (ACI), par obligation légale pour la création d’un CEe, par option choisie de plus en plus fréquemment pour l’engagement d’une entreprise dans une démarche RSE. Nous étudions dans cet article les négociations transnationales menées au sein du groupe Accor. Elles ont eu pour résultats la création précoce d’une instance européenne de consultation des salariés (octobre 1994), puis d’un CEe (juin 1996) et la conclusion du second accord cadre international (juin 1995). L’analyse de ces processus de négociation transnationale et de leurs résultats permet-elle d’identifier un engagement RSE de la direction de l’entreprise ou de mettre en exergue une stratégie de communication d’entreprise, adoptée sans volonté de la direction de s’engager sur le plan social et environnemental ?
La norme ISO 26000 relative à la responsabilité sociétale : une nouvelle source d'usages internationaux
Authors: Cadet Isabelle 
Published: February 2011

ISO 26000 NORM ON SOCIAL RESPONSIBILITY : A NEW SOURCE OF CUSTOMARY LAW Sustainable development concerns have conducted to build an international system of reference recognised by most of the economic actors. With the objective of taking into account the interests of all stakeholders, and also the needs of the present and future generations, the “social responsibility guidelines” have been created. What could possibly be the “legal status” or the place in the legal hierarchy, of the norm ISO 26000 among the 17000 standards issued by the ISO since its creation in 1946 ? Private by its origin, this socio-political standard, can’t leave the scholar indifferent in a context of a globalized world where converging initiatives by private and public actors, aiming at regulating the economic activities, have lead to the emergence of a new form of intervention of the States and the International Institutions in the market. With this new and innovative standardisation process set forth by ISO 26000, which is based on a large consensus, we seem to be witnessing the emergence, or the formalisation, of an international custom. In addition, the universal impact of this “metanorm” raises the question of its potential legal effects and its interface with the “lex mercatoria”, or more generally, to international economic law.
Le phénomène de l'hésitation selon Paul Ricœur
Authors: Boyer Alain 
Published: February 2011

Résumé En 1950, Paul Ricœur publia une imposante Philosophie de la volonté , vite brocardée par la vague structuraliste et les critiques de toute « philosophie de la conscience ». On y trouve notamment une analyse du phénomène de l’hésitation qui contient bien des éléments encore pertinents. Phénomène bien connu, l’hésitation n’a pas été vraiment thématisée en tant que telle, même si, comme le montre Ricœur, l’histoire de la philosophie est susceptible d’aider à le faire. Mais le doute cartésien, par exemple, n’est guère hésitant. Ce chapitre fourmille d’analyses denses mais claires, d’allusions qu’il faut expliciter, de métaphores « vives » très riches, qui permettent de concevoir un sujet se cherchant dans l’hésitation avant de se choisir dans la décision. Il y a là un concept indispensable à toute théorie de l’action.
Investigating water distribution in the Luitel Lake peat bog using MRS, ERT and GPR
Authors: Legchenko Anatoly , Clément Rémi , Garambois Stéphane , Maury Etienne , Mic Lisa‐Maria , Laurent Jean‐Paul , Desplanque Carole , Guyard Hélène 
Published: February 2011

ABSTRACTIn this paper we present the results of a geophysical study of water distribution in the peat bog at Luitel Lake. The goal of the study was to determine water distribution within the bog, which is part of a protected nature preserve. The small peat bog (17 ha) provides a good test site for developing and testing surface geophysical methods. For this study we used magnetic resonance sounding (MRS), electrical resistivity tomography (ERT) and ground‐penetrating radar (GPR). Because the water distribution in the bog is a 2D target for MRS, we had to develop a measuring procedure and 2D inversion routine for MRS. The fieldwork consisted in establishing seventeen MRS stations and conducting three ERT profiles and one GPR line. The MRS, ERT and GPR results on the reservoir geometry correlated well with each other. Pine and birch trees cover most of the bog surface but they have not yet populated the centre of the bog, the location where the maximum water content was observed. This result agrees well with vegetation distribution in the study area: at the centre of the bog, vegetation is typical of a swampy environment but outside the centre the vegetation is typical of a forest. According to MRS, the water content of the peat formation at the centre of the bog is 60–70%, whereas GPR estimated the water content to be between 64–70%. Outside the centre, MRS showed the water content of the peat to be about 30%.
Uridine 5′-Diphosphate Induces Chemokine Expression in Microglia and Astrocytes through Activation of the P2Y6 Receptor
Authors: Kim Beomsue , Jeong Hey-kyeong , Kim Jong-hyeon , Lee Sang Yoon , Jou Ilo , Joe Eun-hye 
Published: February 2011

AbstractChemokines play critical roles in inflammation by recruiting inflammatory cells to injury sites. In this study, we found that UDP induced expression of chemokines CCL2 (MCP-1) and CCL3 (MIP-1α) in microglia, astrocytes, and slice cultures by activation of P2Y6. Interestingly, CCL2 was more highly expressed than CCL3. However, CCL2 synthesis kinetics in response to UDP differed in microglia and astrocytes; microglia rapidly produced small amounts of CCL2, whereas astrocytes continuously synthesized large amounts of CCL2, resulting in a high ultimate level of the chemokine. UDP-induced chemokine expression was reduced in the presence of a specific antagonist of P2Y6 (MRS2578) or small interfering RNA directed against the P2Y6 gene. Inhibition of phospholipase C and calcium increase, downstream signaling pathways of Gq-coupled P2Y6, reduced UDP-induced chemokine expression. UDP activated two calcium-activated transcription factors, NFATc1 and c2. Furthermore, inhibitors of calcineurin (a phosphatase activating NFAT) and NFAT reduced UDP-induced chemokine synthesis. We also found, using a transmigration assay, that UDP-treated astrocytes recruited monocytes. These results suggest that UDP induces chemokine expression in microglia and astrocytes of the injured brain by activation of P2Y6 receptors.
IL-12 Enhances the Antitumor Actions of Trastuzumab via NK Cell IFN-γ Production
Authors: Jaime-Ramirez Alena Cristina , Mundy-Bosse Bethany L. , Kondadasula SriVidya , Jones Natalie B. , Roda Julie M. , Mani Aruna , Parihar Robin , Karpa Volodymyr , Papenfuss Tracey L. , LaPerle Krista M. , Biller Elizabeth , Lehman Amy , Ray Chaudhury Abhik , Jarjoura David , Burry Richard W. , Carson William E. 
Published: February 2011

AbstractThe antitumor effects of therapeutic mAbs may depend on immune effector cells that express FcRs for IgG. IL-12 is a cytokine that stimulates IFN-γ production from NK cells and T cells. We hypothesized that coadministration of IL-12 with a murine anti-HER2/neu mAb (4D5) would enhance the FcR-dependent immune mechanisms that contribute to its antitumor activity. Thrice-weekly therapy with IL-12 (1 μg) and 4D5 (1 mg/kg) significantly suppressed the growth of a murine colon adenocarcinoma that was engineered to express human HER2 (CT-26HER2/neu) in BALB/c mice compared with the result of therapy with IL-12, 4D5, or PBS alone. Combination therapy was associated with increased circulating levels of IFN-γ, monokine induced by IFN-γ, and RANTES. Experiments with IFN-γ–deficient mice demonstrated that this cytokine was necessary for the observed antitumor effects of therapy with IL-12 plus 4D5. Immune cell depletion experiments showed that NK cells (but not CD4+ or CD8+ T cells) mediated the antitumor effects of this treatment combination. Therapy of HER2/neu-positive tumors with trastuzumab plus IL-12 induced tumor necrosis but did not affect tumor proliferation, apoptosis, vascularity, or lymphocyte infiltration. In vitro experiments with CT-26HER2/neu tumor cells revealed that IFN-γ induced an intracellular signal but did not inhibit cellular proliferation or induce apoptosis. Taken together, these data suggest that tumor regression in response to trastuzumab plus IL-12 is mediated through NK cell IFN-γ production and provide a rationale for the coadministration of NK cell-activating cytokines with therapeutic mAbs.
Estriol Generates Tolerogenic Dendritic Cells In Vivo That Protect against Autoimmunity
Authors: Papenfuss Tracey L. , Powell Nicole D. , McClain Melanie A. , Bedarf Ashley , Singh Amber , Gienapp Ingrid E. , Shawler Todd , Whitacre Caroline C. 
Published: February 2011

AbstractChronic inflammation contributes to numerous diseases, and regulation of inflammation is crucial for disease control and resolution. Sex hormones have potent immunoregulatory abilities. Specifically, estrogen influences immune cells and inflammation, which contributes to the sexual dimorphism of autoimmunity and protection against disease seen during pregnancy in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Although long thought to act primarily on T cells, recent evidence demonstrated that myeloid cells, such as dendritic cells (DCs), are essential in mediating estrogen’s protective effects. Estriol (E3), a pregnancy-specific estrogen, has therapeutic efficacy in MS and EAE, and we evaluated whether E3 could act exclusively through DCs to protect against the inflammatory autoimmune disease EAE. Levels of activation markers (CD80 and CD86) and inhibitory costimulatory markers (PD-L1, PD-L2, B7-H3, and B7-H4) were increased in E3 DCs. E3 DCs had decreased proinflammatory IL-12, IL-23, and IL-6 mRNA expression, increased immunoregulatory IL-10 and TGF-β mRNA expression, and a decreased ratio of IL-12/IL-10 protein production. Importantly, transfer of E3 DCs to mice prior to active induction of EAE protected them from developing EAE through immune deviation to a Th2 response. This protection was apparent, even in the face of in vitro and in vivo inflammatory challenge. In summary, our results showed that E3 generates tolerogenic DCs, which protect against the inflammatory autoimmune disease EAE. Targeted generation of tolerogenic DCs with immunomodulatory therapeutics, such as E3, has potential applications in the treatment of numerous autoimmune and chronic inflammatory diseases.
Inhibition of Type 1 Diabetes Correlated to a Lactobacillus johnsonii N6.2-Mediated Th17 Bias
Authors: Lau Kenneth , Benitez Patrick , Ardissone Alexandria , Wilson Tenisha D. , Collins Erin L. , Lorca Graciela , Li Nan , Sankar Dhyana , Wasserfall Clive , Neu Josef , Atkinson Mark A. , Shatz Desmond , Triplett Eric W. , Larkin Joseph 
Published: February 2011

Abstract
Although it is known that resident gut flora contribute to immune system function and homeostasis, their role in the progression of the autoimmune disease type 1 diabetes (T1D) is poorly understood. Comparison of stool samples isolated from Bio-Breeding rats, a classic model of T1D, shows that distinct bacterial populations reside in spontaneous Bio-Breeding diabetes-prone (BBDP) and Bio-Breeding diabetes-resistant animals. We have previously shown that the oral transfer of Lactobacillus johnsonii strain N6.2 (LjN6.2) from Bio-Breeding diabetes-resistant to BBDP rodents conferred T1D resistance to BBDP rodents, whereas Lactobacillus reuteri strain TD1 did not. In this study, we show that diabetes resistance in LjN6.2-fed BBDP rodents was correlated to a Th17 cell bias within the mesenteric lymph nodes. The Th17 bias was not observed in the non-gut–draining axillary lymph nodes, suggesting that the Th17 bias was because of immune system interactions with LjN6.2 within the mesenteric lymph node. LjN6.2 interactions with the immune system were observed in the spleens of diabetes-resistant, LjN6.2-fed BBDP rats, as they also possessed a Th17 bias in comparison with control or Lactobacillus reuteri strain TD1–fed rats. Using C57BL/6 mouse in vitro assays, we show that LjN6.2 directly mediated enhanced Th17 differentiation of lymphocytes in the presence of TCR stimulation, which required APCs. Finally, we show that footpad vaccination of NOD mice with LjN6.2-pulsed dendritic cells was sufficient to mediate a Th17 bias in vivo. Together, these data suggest an interesting paradigm whereby T1D induction can be circumvented by gut flora-mediated Th17 differentiation.
T Cell Development Critically Depends on Prethymic Stromal Patched Expression
Authors: Uhmann Anja , van den Brandt Jens , Dittmann Kai , Heß Ina , Dressel Ralf , Binder Claudia , Lühder Fred , Christiansen Hans , Fassnacht Martin , Bhandoola Avinash , Wienands Jürgen , Reichardt Holger M. , Hahn Heidi 
Published: February 2011

Abstract
We recently described that T cell specification in mice deficient in the Hedgehog (Hh) receptor Patched (Ptch) is blocked at the level of the common lymphoid progenitor in the bone marrow (BM). Adoptive transfer of wild-type BM in Ptch-deficient mice provides evidence that T cell development strictly depends on Ptch expression in the nonhematopoietic compartment. Transplantation experiments using BM deficient in the glucocorticoid receptor exclude any involvement of the stress hormone corticosterone in our model. Using cell-type–specific knockout mice, we show that T cell development is independent of T cell-intrinsic Ptch expression. Furthermore, Ptch expression by the thymus stroma is dispensable, as revealed by fetal thymus organ culture and thymus transplantation. In contrast, analysis of the earliest thymic progenitors in Ptch-deficient mice indicated that Ptch is required for the development or supply of thymic homing progenitors that give rise to earliest thymic progenitors. Collectively, our findings identified Ptch as an exclusive T cell-extrinsic factor necessary for proper development of T cells at their prethymic stage. This observation may be important for current considerations using Hh inhibitors upstream of Ptch in diseases accompanied by aberrant Hh signaling.