bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of reduced astrocyte creatine kinase levels in Alzheimer's disease
Authors: Zheng Tianyu , Kotol David , Sjöberg Rebecca , Mitsios Nicholas , Uhlén Mathias , Zhong Wen , Edfors Fredrik , Mulder Jan 
Published: June 2024

AbstractThe creatine‐phosphocreatine cycle serves as a crucial temporary energy buffering system in the brain, regulated by brain creatine kinase (CKB), in maintaining Adenosine triphosphate (ATP) levels. Alzheimer's disease (AD) has been linked to increased CKB oxidation and loss of its regulatory function, although specific pathological processes and affected cell types remain unclear. In our study, cerebral cortex samples from individuals with AD, dementia with Lewy bodies (DLB), and age‐matched controls were analyzed using antibody‐based methods to quantify CKB levels and assess alterations associated with disease processes. Two independently validated antibodies exclusively labeled astrocytes in the human cerebral cortex. Combining immunofluorescence (IF) and mass spectrometry (MS), we explored CKB availability in AD and DLB cases. IF and Western blot analysis demonstrated a loss of CKB immunoreactivity correlated with increased plaque load, severity of tau pathology, and Lewy body pathology. However, transcriptomics data and targeted MS demonstrated unaltered total CKB levels, suggesting posttranslational modifications (PTMs) affecting antibody binding. This aligns with altered efficiency at proteolytic cleavage sites indicated in the targeted MS experiment. These findings highlight that the proper function of astrocytes, understudied in the brain compared with neurons, is highly affected by PTMs. Reduction in ATP levels within astrocytes can disrupt ATP‐dependent processes, such as the glutamate‐glutamine cycle. As CKB and the creatine‐phosphocreatine cycle are important in securing constant ATP availability, PTMs in CKB, and astrocyte dysfunction may disturb homeostasis, driving excitotoxicity in the AD brain. CKB and its activity could be promising biomarkers for monitoring early‐stage energy deficits in AD.
Soluble Fibrinogen–Like Protein 2 Downregulation and Th17/Treg Imbalance in a Taurocholate‐Induced Murine Experimental Model of Severe Acute Pancreatitis
Authors: Hu Yibing , Ding Jin , Chen Yanping , Wang Qunying , Yang Xiaoyun , Hua Hongjun , Ye Xiaohua 
Published: June 2024

ABSTRACTBackgroundSevere acute pancreatitis (SAP) is associated with tremendous systemic inflammation, T‐helper 17 (Th17) cells, and regulatory T (Treg) cells play an essential role in the inflammatory responses. Meanwhile, soluble fibrinogen–like protein 2 (Sfgl2) is a critical immunosuppressive effector cytokine of Treg cells and modulates immune responses. However, the impact of SAP induction on Sfgl2 expression and the role of Sfgl2 in immunomodulation under SAP conditions are largely unknown.MethodsA taurocholate‐induced mouse SAP model was established. The ratios of CD4+CD25+Foxp3+ Treg cells or CD4+IL‐17+ Th17 cells in blood and pancreatic tissues as well as surface expression of CD80, CD86, and major histocompatibility complex class II (MHC‐II) were determined by flow cytometry. Gene mRNA expression was determined by qPCR. Serum amylase and soluble factors were quantitated by commercial kits. Bone marrow–derived dendritic cells (DCs) were generated, and NF‐κB/p65 translocation was measured by immunofluorescence staining.ResultsSAP induction in mice decreased the Th17/Treg ratio in the pancreatic tissue and increased the Th17/Treg ratio in the peripheral blood. In addition, SAP was associated with a reduced level of Sfgl2 in the pancreatic tissue and blood: higher levels of serum IL‐17, IL‐2, IFN‐α, and TNF‐α, and lower levels of serum IL‐4 and IL‐10. Furthermore, the SAP‐induced reduction in Sfgl2 expression was accompanied by dysregulated maturation of bone marrow–derived DCs.ConclusionsSAP causes reduced Sfgl2 expression and Th17/Treg imbalance, thus providing critical insights for the development of Sfgl2‐ and Th17/Treg balance‐targeted immunotherapies for patients with SAP.
Dental school department strategic planning: A department driven approach
Authors: Marchini Leonardo , Schneider Galen , Stanford Clark 
Published: June 2024

AbstractDrafting strategic plans for dental school departments traditionally involves a committee‐led or leadership‐driven process, often overlooking input from the majority of departmental members. In this manuscript, the authors advocate for a novel approach wherein departmental activities undergo comprehensive review and analysis, and the establishment of novel objectives through diverse forums of engagement with both faculty and staff, conducted collectively and individually over a concise time limit. This methodology endeavors to solicit input from all departmental constituents through varied channels, fostering an environment wherein all members feel empowered to express their viewpoints, resulting in a strategic plan that resonates with the entire department and enhances the likelihood of successful implementation.
Individual differences in the discounting of combination outcomes in which immediate gains are followed by delayed losses
Authors: Ning Ke , Green Leonard , Myerson Joel 
Published: June 2024

AbstractThe vast majority of studies on discounting have focused on simple delayed outcomes, but most everyday decisions are more complicated. The present experiment focused on one such scenario, an iconic self‐control situation in which immediate gains are followed by delayed losses. The same participants were studied in all conditions to permit examination of individual differences in choice behavior using intercorrelations and factor analysis. Consistent with previous research, the hyperboloid model accurately described the form of the discounting function and discounting was not affected by the amount of the delayed loss when it was presented alone. However, replicating other studies, smaller delayed losses were discounted more steeply than larger ones when presented in combination with immediate gains. Exploratory factor analysis revealed two factors, one loading primarily on loss‐only conditions and the other loading primarily on conditions involving outcomes that combined gains and losses. These results imply that there are individual differences in how one combines gains and losses and that this characteristic of individual decision making might be an important predictor of decisions in the many everyday choice situations that involve complex outcomes.
A meta‐analysis and cost‐minimization analysis of cryoballoon ablation versus radiofrequency ablation for paroxysmal atrial fibrillation
Authors: Nitta Yoshimi , Nishimura Michiko , Shibahara Hidetoshi , Yamane Teiichi 
Published: June 2024

AbstractBackgroundPrevious studies have shown inconsistent results in clinical effectiveness between cryoballoon ablation (CBA) and radiofrequency ablation (RFA), and cost assessment between the procedures is important. The aim of this study was to evaluate the clinical effectiveness and cost‐effectiveness between the procedures in patients with paroxysmal atrial fibrillation (AF) refractory to antiarrhythmic drug therapy.MethodsA systematic review and meta‐analysis were performed. The primary outcome for the meta‐analysis was long‐term AF recurrence. Following the results of the meta‐analysis, the cost‐effectiveness of CBA versus RFA in Japan was assessed.ResultsThe meta‐analysis included 12 randomized controlled trials and six propensity‐score matching cohort studies. AF recurrence was slightly lower in patients referred for CBA than for RFA, with an integrated risk ratio of 0.93 (95% confidence interval: 0.81–1.07) and an integrated hazard ratio of 0.96 (95% confidence interval: 0.77–1.19), but no significant difference was found. A cost‐minimization analysis was conducted to compare the medical costs of CBA versus RFA because there was no significant difference in the risk of AF recurrence between the procedures. The estimated costs for CBA and RFA were JPY 4 858 544 (USD 32 390) and JPY 4 505 255 (USD 30 035), respectively, with cost savings for RFA of JPY 353 289 (USD 2355).ConclusionOur meta‐analysis suggests that CBA provides comparable benefits with regard to AF recurrence compared with RFA, as shown in previous studies. Although the choice of treatment should be based on patient and treatment characteristics, RFA was shown that it might be cost saving as compared to CBA.
New SST indices and strength of their correlation with long and short rains over East Africa at different lead times relative to some existing indices
Authors: Assamnew Abera Debebe , Tsidu Gizaw Mengistu 
Published: June 2024

AbstractThis study assesses the skill of existing indices and newly introduced sea surface temperature (SST) indices in predicting rainfall over East Africa (EA) during short rains from September to December (SOND) and long rains from March to May (MAM). The existing and newly introduced indices were selected based on grid point correlation and spatial mean correlation. West–east SST gradient over the Indian Ocean (WEIO), north–south SST gradient over the Pacific Ocean (NSPO), anomalies over the western Indian Ocean (WIO) and anomalies over the eastern Pacific Ocean (EPO) from newly developed indices, and bivariate ENSO time series (BEST), Oceanic Niño Index (ONI), Niño3.4, western Pacific gradient (WPG) and dipole index moment (DMI) from existing indices have a positive correlation with SOND rainfall at 5% () significance level. West–east SST gradient over the Pacific Ocean (WEPO) and SST anomalies over the southern Pacific Ocean (SPO) from new indices and Southern Oscillation Index (SOI) from existing indices have a significant negative correlation with SOND rainfall over EA. SST anomalies over central and eastern Pacific and Indian oceans significantly correlate with SOND rainfall over southern EA (SEA) and equatorial EA (EEA). Rainfall over northern EA (NEA) has a significant negative correlation with SST over the east and central Pacific oceans. Negative correlation extends northeast and southeast from North of Australia over the Pacific Ocean during MAM. WEIO, WIO, NSPO, Niño3.4, Atlantic Oscillation (AO) and WPG have shown strong and significant () relations at least over one subregion. The new SST and existing oceanic indices have a stronger and more significant correlation with short rains than long rains over EA, except in the northern part of EA. Correlation, RMSE and skill score of regression models revealed that new indices showed higher performance than existing indices over EEA and SEA in predicting rainfall, unlike over NEA during both seasons.
A multi‐fidelity residual neural network based surrogate model for mechanical behaviour of structured sand
Authors: Zhou Zhihao , Yin Zhen‐Yu , He Geng‐Fu , Jiang Mingjing 
Published: June 2024

AbstractThe structured sand presents significant interparticle bonding and anisotropy, resulting in significant differences in the physical and mechanical properties from the pure sand. This study proposes a new surrogate model based on the concept of multi‐fidelity residual neural network (MR‐NN) as an alternative to DEM simulation for predicting the mechanical behaviours of structured sand with different initial anisotropy and saving largely computational costs. The model is initially trained using low‐fidelity (LF) data to focus on capturing the main underpinning correlations between macroscopic mechanical parameters with inter‐particle properties and anisotropic state variables (i.e., microscopic fabric and tilting angle of sand), where the LF data are generated from previously proposed anisotropic macro‐micro quantitative correlation. Subsequent training on sparser high‐fidelity (HF) data is used to calibrate and refine the model with HF data generated from DEM simulations for anisotropic structured sand. Feedforward neural network (FNN) is adopted as the baseline algorithm for training models. The macroscopic anisotropic parameters of structured sand predicted by the surrogate model are compared with DEM simulations to examine its feasibility and generalization ability. Furthermore, the robustness of the surrogate model is examined by discussing the effect of LF data on the performance of MR‐NN. The superiority of the MR‐NN is further verified by comparing the performance of the trained MR‐NN with the one‐shot trained FNN based on the same HF data. All results demonstrate that the proposed surrogate model can provide a fast and accurate simulation of the anisotropic parameters of structured sand.
Delay effects on distributed constrained optimization over double‐integrator multi‐agent systems
Authors: Shao Bingxue , Lu Minghui , Shi Xiasheng , Ren Lu 
Published: June 2024

AbstractCommunication plays a pivotal role in distributed optimization problems, where unavoidable communication delays are presented. This research studies the distributed constrained optimization problem concerning second‐order multi‐agent systems with double‐integrator under time‐varying communication delays. An adaptive distributed optimization algorithm using multi‐agent system consensus technique and Karush–Kuhn–Tucker conditions is developed to deal with this problem. The local constraint term is solved adaptively through local dual Lagrange multipliers. When the cost function is strongly convex, and the communication topology is undirected and connected, we employ the Lasalle invariance principle to analyze the delay effects on convergence analysis. Moreover, we give an upper bound on communication delay. Finally, the provided numerical simulation examples demonstrate that the developed method is robust for the limited communication delay and the derived results are conservative.
Consensus recommendations for the use of novel antiretrovirals in persons with HIV who are heavily treatment‐experienced and/or have multidrug‐resistant HIV‐1: Endorsed by the American Academy of HIV Medicine, American College of Clinical Pharmacy: An executive summary
Authors: Cluck David B. , Chastain Daniel B. , Murray Milena , Durham Spencer H. , Chahine Elias B. , Derrick Caroline , Dumond Julie B. , Hester E. Kelly , Jeter Sarah B. , Johnson Melissa D. , Kilcrease Christin , Kufel Wesley D. , Kwong Jeffrey , Ladak Amber F. , Patel Nimish , Pérez Sarah E. , Poe Jonell B. , Bolch Charlotte , Thomas Ian , Asiago‐Reddy Elizabeth , Short William R. 
Published: June 2024

AbstractTreatment options are currently limited for persons with HIV‐1 (PWH) who are heavily treatment‐experienced and/or have multidrug‐resistant HIV‐1. Three agents have been approved by the U.S. Food and Drug Administration (FDA) since 2018, representing a significant advancement for this population: ibalizumab, fostemsavir, and lenacapavir. However, there is a paucity of recommendations endorsed by national and international guidelines describing the optimal use (e.g., selection and monitoring after initiation) of these novel antiretrovirals in this population. To address this gap, a modified Delphi technique was used to develop these consensus recommendations that establish a framework for initiating and managing ibalizumab, fostemsavir, or lenacapavir in PWH who are heavily treatment‐experienced and/or have multidrug‐resistant HIV‐1. In addition, future areas of research are also identified and discussed in the main document.
A comprehensive, updated systematic review and meta‐analysis of epidemiologic evidence on the connection between herpes zoster infection and the risk of stroke
Authors: Heiat Mohammad , Salesi Mahmood , Peypar Mohammad Hossein , Ramazani Ali , Abdorrashidi Mahdi , Yeganeh Amin Vesal 
Published: June 2024

AbstractStroke is a common worldwide cause of death and disability, resulting from an obstruction or reduction in blood flow to the brain. Research has demonstrated that systemic infection such as herpes zoster (HZ) / ophthalmicus herpes zoster (HZO) can potentially trigger stroke. This study includes an updated systematic review and meta‐analysis of the epidemiologic data on the connection between HZ/HZO infection and the risk of stroke. A meticulous search of different database yielded 905 studies. Furthermore, an additional 14 studies from a previous meta‐analysis were incorporated. Eligible studies underwent rigorous screening, resulting in 18 papers. Statistical analyses, including random/fixed effects models and subgroup analyses, were conducted to assess pooled relative risk (RR) and heterogeneity. The meta‐analysis consisted of 5,505,885 participants and found a statistically significant association between HZ infection and the risk of stroke (pooled RR = 1.22, 95% confidence interval [CI] 1.12–1.34). The HZO infection showed a significantly higher overall pooled RR of 1.71 (95% CI 1.06–2.75), indicating a strong connection with the risk of stroke. Subgroup analysis revealed that the odds ratio might play a significant role in causing heterogeneity. Time since infection emerged as a crucial factor, with heightened stroke risk in the initial year post‐HZ/HZO exposure, followed by a decline after the first year. Asian/Non‐Asian studies demonstrated varied results in HZ/HZO patients. Meta‐analysis reveals a significant HZ/HZO‐stroke link. Subgroups highlight varied risks and warrant extended Asian/non‐Asian patient investigation.
Anti‐unwinding attitude maneuver control with predefined time for rigid spacecraft with input saturation
Authors: Xu Yu‐Tian , Wu Ai‐Guo , Dong Rui‐Qi 
Published: June 2024

AbstractIn this article, anti‐unwinding sliding mode attitude maneuver control with predefined time is investigated for rigid spacecraft with input saturation. First, a nonsingular sliding function containing two equilibrium points is designed to ensure the predefined‐time convergence of system states and unwinding‐free performance of the closed‐loop system on the sliding phase. Then, an auxiliary system with a dynamic parameter is presented to compensate the impact of input saturation. With this parameter, the auxiliary system can handle input saturation that occurs. Based on the sliding function and the auxiliary system, an attitude maneuver controller is developed to guarantee the robustness of the closed‐loop system to bounded external disturbance. Under the designed controller, the states of the closed‐loop system are driven into a neighborhood of the sliding surface within a predefined time. Moreover, the unwinding phenomenon is also avoided on the reaching phase. Numerical simulation results illustrate the unwinding‐free performance and predefined‐time convergence of the closed‐loop system under the proposed control strategy.
Toward sustainable development: Revealing the dynamic impacts of the belt and road initiative on energy transition
Authors: Chishti Muhammad Zubair , Sharif Arshian , Xu Qi , Sharma Gagan Deep 
Published: June 2024

AbstractThis article investigates the influence of the belt and road initiative (BRI) on energy transition within the context of sustainable development goal (SDG) 7. The study utilizes daily data from May 3, 2017, to June 30, 2023, and deploys advanced econometric methods like heatmap‐based QVAR, cross‐quantilogram, and recursive time‐varying methods. The findings determine that BRI can significantly foster the global energy transition process. Further, the Paris Agreement (PA) and green finance (GF) support the energy transition system by showing positive effects. In contrast, geopolitical risk (GPR) introduces disruptive elements that impede green energy production. Notably, the amalgamation of GF, PA, and BRI showcases the potential to not only facilitate SDG 7 but also contribute substantially to SDGs 8 and 13. Based on the above findings, the study suggests fostering synergies and collaboration between GF, PA, and BRI to maximize their combined impact on the energy transition, which may decrease the influence of GPR.
Deficiencies of women's participation in climate governance and sustainable development challenges in Bangladesh
Authors: Humayra Jeba , Uddin Md. Kamal , Pushpo Nusrat Yeasmin 
Published: June 2024

AbstractIn Bangladesh, women endure the consequences of climate change while also serving a crucial role in domestic and community‐led climate change responses. Given the gender power dynamics that have developed in Bangladesh, integrating women as distinguishable actors and effective agents in climate governance remains a challenge. Bangladesh is a traditionally patriarchal society, and because of deeply ingrained gender inequalities, men dominate the family, community, and society. Most research has been conducted on women's vulnerability and victims, but only a few were conducted on how women can be change‐makers. This research found that with women's contribution and equal participation, achieving effective climate governance in Bangladesh is possible. The study also discovered that the absence of women from climate governance perpetuates gender inequality and makes it more challenging to achieve sustainable development objectives. The intricate relationships between gender equality, efficient climate governance, and the more general aim of sustainable development within the context of Bangladesh are explored in this study. In light of the findings, the study argues for and puts forward policy proposals for recognizing women's active contribution as change makers and supporting gender equality as a crucial strategy in climate governance in Bangladesh.
An Extensive Analysis of Current Synthetic Methodologies and Applications of Imidazo/Benzimidazo[1,2‐c]Quinazolines
Authors: Bairy Gurupada , Sinha Chittaranjan 
Published: June 2024

AbstractA great deal of attention has been received on developing N‐heterocyclic compounds due to their ambitious biological activities. Many of them are essential footstep to the development and discovery of new drugs. Imidazole/benzimidazole and quinazoline are essential pharmacologically active N‐heterocycles, and one of the molecular framework built up from their combination, imidazo/benzimidazo[1,2‐c]quinazoline, is of great attention in terms of synthesis, reactions, and medicinal applications. The positional variation of hetero N‐atoms and the functional groups acting as substituents in the main scaffold have a direct impact on the properties of imidazo/benzimidazo[1,2‐c]quinazolines. In addition to its physiological activities, this moiety is useful for electrical conductivity, molecules/ions sensing, coordination complex and coordination polymer (CP) formation, and their diverse applications. The major objective of this review is to highlight various synthetic approaches for imidazo/benzimidazo[1,2‐c]quinazolines motif since 2000. Toxicant‐free reaction conditions and the use of an extensive range of inexpensive substrates are two of the main practical benefits of the protocol in accomplishing the sustainable development goals.