bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origin of the Red‐veined Darter dragonflies migrating into the European part of Russia revealed by stable isotopes of hydrogen
Authors: Borisov Alexey S. , Borisov Sergey N. , Iakovlev Ivan K. , Onishko Vladimir V. , Ganin Mikhail Yu. , Tsurikov Sergey M. , Tiunov Alexei V. 
Published: June 2024

Abstract
Dragonflies are well‐known migratory insects, and stable isotopes have been used successfully to study their migrations in America and Asia but less so in Europe.
Here we used the isotopic composition of hydrogen (δ2H value) in metabolically inert wing tissues of the dragonfly Sympetrum fonscolombii (Selys, 1840) to investigate migration patterns and likely origin of immigrants into the European part of Russia. During spring–summer, sexually mature dragonflies arrive to Russia for reproduction and individuals of the summer generation (descendants of immigrants) presumably migrate in the opposite direction in the fall.
Analyses included 39 specimens of immigrant S. fonscolombii dragonflies, 11 specimens from 3 species of resident dragonflies (including S. fonscolombii) from the European part of Russia and 16 specimens representing 9 resident dragonfly species from Iran.
The average δ2H values of the wings of immigrant S. fonscolombii (−71.9 ± 23.4‰) were significantly higher than those of resident dragonflies in European Russia (−121.7 ± 9.5‰) and similar to those of resident dragonfly species from Iran (−72.3 ± 18.4‰).
Based on a geostatistical model of the global δ2H values in precipitation, and considering the distribution of S. fonscolombii, the most probable natal area of immigrants arriving in European Russia is located in Southwest Asia. The suggested migration zone covers regions located between approximately 26°–28° N in the south and 56°–58° N in the north, while the migration distance can reach 2000–4000 km.
Effect of orthotopic neobladder reconstruction on quality of life: A systematic review
Authors: Özer Özlü Nazife Gamze , Çolak Sevgi , Vural Fatma 
Published: June 2024

AbstractHow does orthotopic neobladder reconstruction in the surgical treatment of bladder cancer patients affect the quality of life? In the literature, the results affecting the quality of life from patient‐reported outcome measures in bladder cancer patients who underwent orthotopic neobladder are not fully known. In this systematic review, the effect of orthotopic neobladder reconstruction on the quality of life in patients with bladder cancer is examined. Literature search was conducted within the framework of PRISMA guidelines and PICO. The research question was conducted in line with the core elements of Population, Concept and Context (PCC) proposed by the Joanna Briggs Institute (JBI) methodology. In the study, international studies published in Medline/PubMed, Cochrane, Web of Science, ProQuest and Scopus databases between 2012 and 2022 and accessible with the keywords ‘quality of life, ileal conduit, orthotopic neobladder, and continent diversion’ were reviewed. Methodological evaluation was performed by three independent authors with the JBI checklist. Six cross‐sectional studies with 1485 samples and 12 prospective cohort studies with 1555 samples were included in the review. The Cronbach's alpha coefficient of the checklists was 0.98 in cross‐sectional studies and 0.97 in prospective cohort studies. In studies, it was observed that the European Organization for Research and Treatment of Cancer‐Quality of Life (EORTC‐Quality of Life) scale was mostly used in patients' quality of life. In cross‐sectional studies, there is no difference in quality of life between orthotopic neobladder and continent diversions, the quality of life related to bowel function is high in orthotopic neobladder, the quality of life related to urinary and sexual function is low, different surgical techniques in orthotopic neobladder do not affect the quality of life between women and men. It was determined that the factors affecting the quality of life were different and that chemotherapy and radiotherapy had different effects on the quality of life. In prospective cohort studies, it was found that comorbid diseases affect the quality of life, but orthotopic neobladder improves the quality of life of patients in the long term, there is no difference in quality of life between incontinent and continent diversions, and orthotopic neobladder has a positive effect on quality of life, especially in women. The studies conducted show that the studies on the quality of life of patients with orthotopic neobladder are limited and studies with strong effect sizes are needed. This review recommends that more studies be conducted to improve the physical‐psychological health, social relationships and environmental quality of life of patients with orthotopic neobladder and that support programs be developed for these patients.
Antibacterial mechanism and structure–activity relationships of Bombyx mori cecropin A
Authors: Tian Yuyuan , Wei Hongxian , Lu Fuping , Wu Huazhou , Lou Dezhao , Wang Shuchang , Geng Tao 
Published: June 2024

AbstractBombyx mori cecropin A (Bmcecropin A) has antibacterial, antiviral, anti‐filamentous fungal and tumour cell inhibition activities and is considered a potential succedaneum for antibiotics. We clarified the antibacterial mechanism and structure–activity relationships and then directed the structure–activity optimization of Bmcecropin A. Firstly, we found Bmcecropin A shows a strong binding force and permeability to cell membranes like a detergent; Bmcecropin A could competitively bind to the cell membrane with the cell membrane‐specific dye DiI, then damaged the membrane for the access of DiI into the cytoplasm and leading to the leakage of electrolyte and proteins. Secondly, we found Bmcopropin A could also bind to and degrade DNA; furthermore, DNA library polymerase chain reaction (PCR) results indicated that Bmcecropin A inhibited DNA replication by non‐specific binding. In addition, we have identified C‐terminus amidation and serine‐lysine‐ glycine (SLG) amino acids of Bmcecropin A played critical roles in the membrane damage and DNA degradation. Based on the above results, we designed a mutant of Bmcecropin A (E9 to H, D17 to K, K33 to A), which showed higher antibacterial activity, thermostability and pH stability than ampicillin but no haemolytic activity. Finally, we speculated that Bmcecropin A damaged the cell membrane through a carpet model and drew the schematic diagram of its antibacterial mechanism, based on the antibacterial mechanism and the three‐dimensional configuration. These findings yield insights into the mechanism of antimicrobial peptide–pathogen interaction and beneficial for the development of new antibiotics.
Impact of an evidence‐based bundle on incontinence‐associated dermatitis prevalence in hospital patients: A quasi‐experimental translational study
Authors: Barakat‐Johnson Michelle , Stephenson John , Lai Michelle , Basjarahil Shifa , Campbell Jayne , Cunich Michelle , Disher Gary , Geering Samara , Ko Natalie , Leahy Catherine , Leong Thomas , McClure Eve , O'Grady Melissa , Walsh Joan , White Kate , Coyer Fiona 
Published: June 2024

AbstractThe study aimed to evaluate the effect of an intervention on the prevalence and severity of incontinence‐associated dermatitis (IAD) in six hospitals in one state in Australia. This quasi‐experimental pre‐and post‐study, conducted in 18 wards, was part of a larger implementation science study on incontinence‐associated dermatitis. Skin and incontinence assessments were conducted on patients during February and March 2020 (pre‐intervention) and July and August 2021 (post‐intervention). The intervention comprised continence assessment and management, an education brochure for patients, family and caregivers on IAD, the Ghent Global IAD Categorisation Tool (GLOBIAD) and a skin care regime with patient skin protection measures (three‐in‐one barrier cream cloths, minimisation of bed protection layers, use of appropriate continence aid). A total of 1897 patients were assessed (pre‐intervention = 964, post‐intervention = 933). A total of 343 (35.6%) pre‐intervention patients and 351 (37.6%) post‐intervention patients had incontinence. The prevalence of hospital‐acquired IAD was 6.71% in the pre‐intervention group and 4.27% in the post‐intervention group; a reduction of 36.3% (p = 0.159) despite higher patient acuity, prevalence of double incontinence and the COVID‐19 pandemic in the post‐intervention group compared with the pre‐intervention group. Our multisite best practice IAD prevention and treatment intervention was able to reduce the prevalence and severity of hospital‐acquired IAD, suggesting enduring effectiveness of the intervention.
The voice of retail investors and corporate earnings quality
Authors: Cai Guilong , Lin Bingxuan , Lu Rui , Zhang Yanan 
Published: June 2024

AbstractChinese stock exchanges have launched two investor interactive exchange platforms (IIEPs) to facilitate communication between retail investors and listed companies. Using retail investor posts on the IIEPs as a proxy for monitoring by minority shareholders, we show that minority shareholders can play an active monitoring role in corporate governance and improve earnings quality. We identify coordination among minority shareholders and increased regulatory scrutiny as key mechanisms through which IIEPs exert their influence. This form of monitoring proves critical, especially in the absence or ineffectiveness of traditional oversight bodies like institutional investors, auditors and government regulators. Our findings underscore the constructive role of minority shareholders in corporate governance, challenging the notion of them as passive free riders. Implementing IIEPs could be a valuable model for other nations looking to bolster minority shareholder rights.
Regulation of biofilm gene expression by DNA replication in Bacillus subtilis
Authors: Wu Renjie , Kong Ling‐Xing , Liu Feng 
Published: June 2024

AbstractBacillus subtilis relies on biofilms for survival in harsh environments. Extracellular polymeric substance (EPS) is a crucial component of biofilms, yet the dynamics of EPS production in single cells remain elusive. To unveil the modulation of EPS synthesis, we built a minimal network model comprising the SinI‐SinR‐SlrR module, Spo0A, and EPS. Stochastic simulations revealed that antagonistic interplay between SinI and SinR enables EPS production in bursts. SlrR widens these bursts and increases their frequency by stabilizing SinR‐SlrR complexes and depleting free SinR. DNA replication and chromosomal positioning of key genes dictate pulsatile changes in the slrR:sinR gene dosage ratio (gr) and Spo0A‐P levels, each promoting EPS production in distinct phases of the cell cycle. As the cell cycle lengthens with nutrient stress, the duty cycle of gr pulsing decreases, whereas the amplitude of Spo0A‐P pulses elevates. This coordinated response facilitates keeping a constant proportion of EPS‐secreting cells within colonies across diverse nutrient conditions. Our results suggest that bacteria may ‘encode’ eps expression through strategic chromosomal organization. This work illuminates how stochastic protein interactions, gene copy number imbalance, and cell‐cycle dynamics orchestrate EPS synthesis, offering a deeper understanding of biofilm formation.
Evaluating the relationship between facility Age‐Friendly recognition and subsequent facility‐free days in older Veterans
Authors: Burke Robert E. , Tjader Andrew , Church Kimberly , Munro Shannon , Rose Liam 
Published: June 2024

AbstractBackgroundThousands of health systems have been recognized as “Age‐Friendly” for implementing geriatric care practices aligned with the “4Ms” (What Matters, Medication, Mentation, and Mobility). However, the effect of Age‐Friendly recognition on patient outcomes is largely unknown. We sought to identify this effect in the Veterans Health Administration (VHA)—one of the largest Age‐Friendly integrated health systems in the United States.MethodsThere were 50 VA medical centers (VAMCs) recognized as Age‐Friendly by December 2021. We used a time‐event difference‐in‐difference analysis to identify the association of a VAMC's recognition as Age‐Friendly on the change in facility‐free days (days outside the hospital or nursing home) among Veterans treated at that facility. We also evaluated this association in three subgroups: Veterans at particularly high risk of nursing home entry, Veterans who lived within 10 miles of a medical center, and facilities that had reached Level 2 Age‐Friendly recognition. We also evaluated individual components of the endpoint in terms of change in hospital and nursing home days separately.ResultsWe found Age‐Friendly recognition was associated with small statistically significant improvements in facility‐free days (0.2% on a base of 97% facility‐free days on average per year, or an additional 0.73 days per year on a base of 354 days). There were no differences in any subgroup, or any individual component of the endpoint across all groups.ConclusionsAt the individual level, an increase of 0.2% in facility‐free days is a weak effect. However, sites were early in implementation, and facility‐free days may not be a responsive outcome measure. However, across an entire population, small changes in facility‐free days may accrue large cost savings. Future evaluations should consider a broader variety of process and outcome measures.
KLHL17 differentially controls the expression of AMPA‐ and KA‐type glutamate receptors to regulate dendritic spine enlargement
Authors: Hu Hsiao‐Tang , Hsueh Yi‐Ping 
Published: June 2024

AbstractKelch‐like family member 17 (KLHL17), an actin‐associated adaptor protein, is linked to neurological disorders, including infantile spasms and autism spectrum disorders. The key morphological feature of Klhl17‐deficient neurons is impaired dendritic spine enlargement, resulting in the amplitude of calcium events being increased. Our previous studies have indicated an involvement of F‐actin and the spine apparatus in KLHL17‐mediated dendritic spine enlargement. Here, we show that KLHL17 further employs different mechanisms to control the expression of two types of glutamate receptors, that is, α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) and kainate receptors (KARs), to regulate dendritic spine enlargement and calcium influx. We deployed proteomics to reveal that KLHL17 interacts with N‐ethylmaleimide‐sensitive fusion protein (NSF) in neurons, with this interaction of KLHL17 and NSF enhancing NSF protein levels. Consistent with the function of NSF in regulating the surface expression of AMPAR, Klhl17 deficiency limits the surface expression of AMPAR, but not its total protein levels. The NSF pathway also contributes to synaptic F‐actin distribution and the dendritic spine enlargement mediated by KLHL17. KLHL17 is known to act as an adaptor mediating degradation of the KAR subunit GluK2 by the CUL3 ubiquitin ligase complex, and Klhl17 deficiency impairs activity‐dependent degradation of GluK2. Herein, we further demonstrate that GluK2 is critical to the increased amplitude of calcium influx in Klhl17‐deficient neurons. Moreover, GluK2 is also involved in KLHL17‐regulated dendritic spine enlargement. Thus, our study reveals that KLHL17 controls AMPAR and KAR expression via at least two mechanisms, consequently regulating dendritic spine enlargement. The regulatory effects of KLHL17 on these two glutamate receptors likely contribute to neuronal features in patients suffering from certain neurological disorders.image
Nurses' perceptions of the design, implementation, and adoption of machine learning clinical decision support: A descriptive qualitative study
Authors: Wieben Ann M. , Alreshidi Bader G. , Douthit Brian J. , Sileo Marisa , Vyas Pankaj , Steege Linsey , Gilmore‐Bykovskyi Andrea 
Published: June 2024

AbstractIntroductionThe purpose of this study was to explore nurses' perspectives on Machine Learning Clinical Decision Support (ML CDS) design, development, implementation, and adoption.DesignQualitative descriptive study.MethodsNurses (n = 17) participated in semi‐structured interviews. Data were transcribed, coded, and analyzed using Thematic analysis methods as described by Braun and Clarke.ResultsFour major themes and 14 sub‐themes highlight nurses' perspectives on autonomy in decision‐making, the influence of prior experience in shaping their preferences for use of novel CDS tools, the need for clarity in why ML CDS is useful in improving practice/outcomes, and their desire to have nursing integrated in design and implementation of these tools.ConclusionThis study provided insights into nurse perceptions regarding the utility and usability of ML CDS as well as the influence of previous experiences with technology and CDS, change management strategies needed at the time of implementation of ML CDS, the importance of nurse‐perceived engagement in the development process, nurse information needs at the time of ML CDS deployment, and the perceived impact of ML CDS on nurse decision making autonomy.Clinical RelevanceThis study contributes to the body of knowledge about the use of AI and machine learning (ML) in nursing practice. Through generation of insights drawn from nurses' perspectives, these findings can inform successful design and adoption of ML Clinical Decision Support.
Exploration of low‐phosphate diet management of patients receiving renal dialysis: An interpretive description
Authors: Christensen Kenneth M. , Bauer Eithne H. , Prinds Christina 
Published: June 2024

AbstractBackgroundPatients with dialysis‐dependent kidney failure and treated for hyperphosphatemia receive a combination of dietary advice, phosphate binders and prolonged dialysis. However, research focusing on the challenges patients meet in everyday life addressing diet and medication is sparse.ObjectiveThe objective of this study is to explore the everyday challenges patients meet when following treatment for hyperphosphatemia.DesignInterpretive description was the methodological approach. Semistructured in‐depth interviews were employed to study the challenges patients experienced. Data were analysed using Braun and Clarke's reflexive thematic analysis.ParticipantsPatients (n = 14) receiving haemodialysis and treated for hyperphosphatemia from two hospitals in Southern Denmark.FindingsThe analysis resulted in one over‐arching theme; separation in social gatherings and two subthemes; a new social code, and my food and their food. Participants experienced difficulty integrating diet and medication in daily life, especially at social gatherings. They felt separated from others when special menus were provided for them or struggled when choosing between high and low phosphate‐containing food. A new awareness of self and others arose, especially their position among families and friends, and how they presented themselves and their social identity to others. Likewise, a new social code manifested itself, which was difficult to accept. Most participants experienced that diet and medication were accompanied by a moral responsibility of whether to accept prepared food with high phosphorus content or not, which affected commensality.ConclusionPatients were often nonadherent to hyperphosphatemia treatment at social gatherings. Hyperphosphatemia treatment led to new social identities with new social codes, which patients found difficult to accept.
Treatment of periodontitis ameliorates the severity and extent of psoriasis—A randomized clinical trial
Authors: Marruganti Crystal , Romandini Mario , Gaeta Carlo , Trovato Emanuele , Cinotti Elisa , Rubegni Pietro , D'Aiuto Francesco , Grandini Simone 
Published: June 2024

AbstractAimTo assess the impact of non‐surgical periodontitis treatment over conventional dermatological treatment on the severity and extent of psoriasis in patients affected by comorbid psoriasis and periodontitis.MethodsSeventy‐four patients affected by both psoriasis and Stages I–IV periodontitis were randomized to receive either Steps 1–2 (non‐surgical) of periodontal therapy (test group; n = 37) or no treatment (control group; n = 37). The two groups were balanced in terms of psoriasis medications, with the majority of the included patients undergoing biologics (74.0%) as monotherapy, while minor proportions were under systemic medications (13.7%) or none/topical/phototherapy (12.3%). The psoriasis area severity index (PASI) was regarded as the primary outcome. The Body Surface Area (BSA) and the Dermatology Life Quality Index (DLQI) were additionally considered as dermatological outcomes. Probing pocket depth, recession depth, clinical attachment level, periodontal inflamed surface area, and full‐mouth plaque and bleeding scores were also measured. [Correction added on July 5, 2024, after first online publication: The preceding sentence has been revised].ResultsPeriodontal therapy in the test group led to statistically significant lower PASI scores at 10 weeks (mean = 3.15; standard deviation [SD] = 3.78) compared to the control group (mean = 7.11; SD = 6.09) (mean difference [MD] = ‐4.0; 95% confidence interval [CI]: −6.3, −1.6; p = .001). The test group also showed improvements in BSA (MD = −4.3) and periodontal parameters compared to the control group. DLQI only showed a non‐statistically significant tendency (MD = −2.0).ConclusionSteps 1–2 of periodontal therapy showed an additional effect over conventional dermatological treatment in reducing the severity and extent of psoriasis (Clinicaltrials.gov: NCT05311501).
Subclinical infection and potential shedding routes of equine parvovirus‐hepatitis among hospitalized horses in Austria
Authors: Lale Dilara , Dirks Esther E. , Preining Irina , Lyrakis Manolis , Gömer Andre , Steinmann Eike , Cavalleri Jessika‐M. V. , Ramsauer Anna Sophie 
Published: June 2024

AbstractBackgroundEquine parvovirus hepatitis (EqPV‐H) can cause Theiler's disease and subclinical hepatitis in horses.ObjectivesAssess the frequency of subclinical EqPV‐H infection in hospitalized horses and to study viral transmission by investigating potential shedding routes.AnimalsOne hundred sixteen equids, that presented to the University Equine Hospital of the University of Veterinary Medicine Vienna between February 2021 and March 2022, for causes other than hepatopathy.MethodsIn this cross‐sectional study, samples (serum, feces, nasal, and buccal swabs) of hospitalized horses were collected. Sera were screened for the presence of anti‐EqPV‐H antibodies by a luciferase immunoprecipitation system assay. Quantitative PCR was used for the detection of EqPV‐H DNA in the samples and a nested PCR was used for further validation.ResultsSeroprevalence was 10.3% (12/116) and viremia occurred in 12.9% (15/116) of the serologically positive horses. The detected viral load in serum varied from non‐quantifiable amount to 1.3 × 106 genome equivalents per milliliter of serum. A low viral load of EqPV‐H DNA was detected in 2 nasal swabs and 1 fecal sample.Conclusion and Clinical ImportanceEqPV‐H DNA was detected in nasal secretions and feces of viremic horses, which could pose a risk to naive hospitalized horses. It is advisable to screen hospitalized horses that are potential donors of blood or plasma to reduce the risk of iatrogenic EqPV‐H transmission.