bluuebunny/crossref_metadata_2025_split huggingface dataset:
Geochronology and geochemistry of granitoids from northern Alxa, northwest China: Petrogenesis and tectonic implications
Authors: Wu Chunjiao , Wang Zhenyi , Zhang Jin , Liu Jianfeng , Zhang Beihang , Zheng Rongguo , Ma Jun , Hui Jie , Zhao Heng 
Published: May 2024

AbstractMultiple branch oceans existed in the Paleo‐Asian Ocean (PAO), but their closure times are in dispute and unclear, which constrains our understanding of the final closure time of the PAO and the tectonic evolution of the Central Asian Orogenic Belt (CAOB). This study focuses on the Permian plutons of the northern Alxa, which is located in the middle segment of the southern CAOB that recorded the final subduction history of the PAO. We performed the 1:50000 mapping, whole‐rock geochemistry, geochronology, and Sr‐Nd‐Hf isotopic analysis and compiled the Sr‐Nd‐Hf isotopic compositions and whole‐rock geochemical data of igneous rocks from the northern Alxa. LA‐ICP‐MS zircon U–Pb dating reveals the study plutons emplaced in the Early Permian (285–296 Ma). Whole‐rock geochemical data show the intrusion belongs to medium‐K calc‐alkaline peraluminous highly fractionated I‐type granite, enriched in Rb, K, Th, Pb, and depleted in Nb, Ta, Ti, Sr, and P elements, which suggest a subduction arc‐related setting and metaluminous to weak peraluminous parental magma. The weak negative εNd(t) (from −2.3 to −1.2), relatively high ISr (0.704772–0.708037) and depleted mantle model ages TDM (1.14–1.49 Ga), combining with weak negative to slightly positive εHf(t) (from −2.0 to +4.1) and crustal model ages TDMC (1.18–1.43 Ga), indicate that the parental magma might originate from remelting of the Mesoproterozoic lower crust and mixing with mantle‐derived materials. The field occurrence, deformation, and geochemical features, integrating with the compiled data and regional geology, show that the igneous rocks formed before or after the late Early Permian show different features in terms of deformation, zircon saturation temperatures, crustal thickness, potassium contents, and εHf(t) values. This might relate to the closure of the Yagan branch ocean of the PAO in northern Alxa.
2020 Klein Lecture—Investment and Subjective Uncertainty
Authors: Bloom Nicholas , Davis Steven J. , Foster Lucia , Ohlmacher Scott , Saporta‐Eksten Itay 
Published: May 2024

AbstractA longstanding challenge in evaluating the impact of uncertainty on investment is obtaining measures of managers’ subjective uncertainty. We address this challenge by using a detailed survey measure of uncertainty collected by the U.S. Census Bureau for approximately 25,000 manufacturing plants. We find three key results. First, investment is negatively associated with higher uncertainty. Second, uncertainty is also negatively related to employment growth and overall shipments growth, which highlights the damaging impact of uncertainty. Third, rental capital and temporary workers are positively correlated with uncertainty, demonstrating that businesses switch from less flexible to more flexible inputs under uncertainty.
Balanoposthitis in type 2 diabetes mellitus within a brief duration: A case report
Authors: Rajkumar Kanish Akash , Nagapavani Kothapalli , Kumar Mudigubba Manoj 
Published: May 2024

AbstractThis case report documents the rapid onset of balanoposthitis in a 58‐year‐old male patient diagnosed with type 2 diabetes mellitus just 2 weeks prior. The patient presented with acute penile pain, swelling, and purulent discharge, necessitating circumcision due to balanoposthitis and phimosis. The diagnosis of type 2 diabetes mellitus 14 days prior highlights the potential for rapid development of balanoposthitis despite practicing proper hygiene. This underscores the importance of healthcare practitioners proactively examining the penile area in newly diagnosed diabetic patients to prevent balanoposthitis and, conversely, screening patients with balanoposthitis for type 2 diabetes mellitus.
Evaluation of near‐infrared digital imaging transillumination compared with bitewing radiography for proximal caries detection in children
Authors: Patel Jilen , Vannemreddy Akhil , Goh Yee Jing , Francis Youssef , Anthonappa Robert 
Published: May 2024

AbstractBackgroundLimitations in traditional caries detection tools have driven the development of alternatives methods, focused on the early lesion detection such as near‐infrared digital imaging transillumination (NIDIT).AimThe aim of this study was to evaluate the performance of NIDIT compared with bitewing radiography (BWR) in the detection of interproximal carious lesions in children.DesignA retrospective audit of data from children who had NIDIT, BWR and intraoral photographs was conducted. Carious lesions were scored on a tooth surface level with BWR acting as the primary reference for comparison. Accuracy was determined using multi‐class area under the curve (AUC), and correlation was determined using Fleiss' Kappa.ResultsData from 499 tooth surfaces involving 44 children were included in this study. The average age across the participants was 86 months (~7 years) with an average dmft (decayed, missing and filled teeth in primary dentition) of 5.29. Multi‐class AUC comparing NIDIT to BWR was 0.70. The correlation between NIDIT and BWR was moderate (0.43), whereas the correlation between photographic examination and BWR was 0.30, which is fair.ConclusionWhen compared to BWR, NIDIT showed a high specificity but a low sensitivity for proximal caries detection in primary teeth.
Blockchain adoption strategy in a platform dual‐channel supply chain with risk‐averse sellers
Authors: Zhang Huimin , Lou Zhenkai , Hou Fujun , Yan Yan 
Published: May 2024

AbstractThis paper investigates blockchain technology (BT) adoption strategy in a platform dual‐channel supply chain, wherein the supplier establishes a direct selling channel (DC) in addition to the existing reselling channel (RC) of the e‐retailer. Both the supplier and the e‐retailer are risk‐averse, and they have access to consumers through a common online platform. The online platform possesses the capability to introduce BT and can opt to introduce it to neither, one (DC or RC) or both channels. Game models for the four strategies are developed, and the corresponding equilibrium outcomes are obtained using backward induction. Our analysis reveals that when competition intensity is high and both perceived risk aversion level and BT's unit cost are low, the online platform prefers only DC with adopting BT. Otherwise, it prefers both channels with adopting BT. The supplier shares the same preference as the online platform for BT adoption strategy. Interestingly, the e‐retailer prefers only DC with adopting BT only when BT's unit cost is high; otherwise, she prefers solely RC with adopting BT. Furthermore, we enhance the basic model by modifying parameter configurations and the sequence game, and verify that our main findings in these extensions remain robust.
Thirst symptoms in patients with heart failure: An integrative review
Authors: Zheng Yingjun , Chen Qiongshan , Xia Chengyu , Liu Hui 
Published: May 2024

AbstractAimTo identify the risk and protective factors affecting thirst symptoms in patients with heart failure (HF) and intervention strategies to alleviate thirst symptoms.DesignAn integrative review.MethodsA total of 61 articles were retrieved. Screening yielded a total of 21 articles which were appraised for quality. The quality of studies was assessed using the Mixed Methods Appraisal Tool.Data SourcesTen electronic databases were searched in October 2023, including Embase, Pubmed, CINAHL, Cochrane, Web of Science, Wiley, CNKI, VIP, CBM and WanFang. In addition, we searched grey databases and manually searched reference lists of included and relevant reviews.ResultsIn total, 1644 articles were retrieved, of which 21 were included. Eight studies addressed the factors. Six themes emerged as risk factors, including demographics, severity of disease, psycho‐environmental, medication, fluid restriction and homeostasis. Conversely, an increase in fluid intake, a high score of sodium restriction diet attitude and using ARB were identified as protective factors. Thirteen studies focus on intervention strategies. Five unique intervention strategies were identified, including Traditional Chinese Medicine, mint‐related interventions, sour‐flavour interventions, improved water restriction and cluster nursing strategy.ConclusionThis finding identified the factors associated with thirst symptoms in patients with HF, especially concerning the elaboration of risk factors, which suggests that healthcare professionals should focus on the risk factors for thirst in patients with HF and consciously avoid the occurrence of these risk factors. Additionally, there are considerable cultural differences in interventions, therefore, to increase adherence during symptom management, careful selection of appropriate intervention strategies based on the requirements and preferences of patients is required. While there are some therapies, there aren't enough high‐quality empirical investigations. Thus, multi‐centre, large‐sample studies are also required in subsequent research to demonstrate the interventions' effectiveness.Implications for the ProfessionThe nurse must notice the symptoms of thirst in HF to slow down the disease's progression and improve the patient's physical and emotional well‐being.Reporting MethodThe review complies with the PRISMA guidelines for reporting systematic reviews.Patient or Public ContributionNo patient or public contribution.
A behavioural description of meaningful moments of interaction between people with profound intellectual disabilities and support staff
Authors: Penninga Wieneke , Hendriks Alexander H. C. , van Bakel Hedwig J. A. , Embregts Petri J. C. M. 
Published: May 2024

AbstractBackgroundIt can be challenging for support staff to develop meaningful moments of interaction with people with profound intellectual disabilities. Gathering information on observable behaviour characterising such meaningful moments is expected to be beneficial.MethodThree staff‐client dyadic interactions were videotaped for 30 min. During reviewing the recording, staff members indicated which moments of interaction they experienced as meaningful. Per dyad, one meaningful moment was microanalytically coded via a developed coding system, and behaviourally described.ResultsThe coding system reliably coded behaviour at the micro level. Exploratory results indicated that looking, movement and touching were most shown, and that staff displayed this behaviour more frequently than their clients. Both exhibited behaviours substantially more often during meaningful moments than at their onset.DiscussionPeople with profound intellectual disabilities are more engaged during meaningful moments of interaction compared to at their onset. In daily practice, cultivating circumstances increasing their involvement is important.
A comparative assessment of drying kinetics, energy consumption, mathematical modeling, and multivariate analysis of Indian borage (Plectranthus amboinicus) leaves
Authors: Rout Rahul Kumar , Kumar Ankit , Rao Pavuluri Srinivasa 
Published: May 2024

AbstractIn the current study, four drying methods, namely microwave (MD), vacuum (VD), hot air (HAD), and freeze drying (FD), were compared for drying of Indian borage (Plectranthus amboinicus) leaves for optimum energy consumption and bioactive compounds' retention. Effective moisture diffusivity for MD was about 100 times more than that of HAD and VD. MD at 600 W showed minimum specific energy consumption (4.04 kWh/kg), proving the most suitable drying condition. Moreover, it showed desirable energy values in terms of maximum specific moisture extraction rate (0.265 kg moisture/kWh) and maximum drying efficiency (15.85%). Bioactive compounds' retention in terms of phenols, antioxidants, and flavonoids was better in MD, followed by FD. Mathematical modeling of drying kinetics data revealed proper fitting of three drying models, namely, Aghbashlo, Modified Page‐II, and Page model, for explaining the drying behavior of Indian borage leaves. Multivariate characterization using principal component analysis revealed that FD and MD had a strong effect on bioactive compounds' retention, while VD and HAD showed least effect. Hence, based on optimum energy utilization and bioactive compounds' retention, MD at 600 W was selected for efficient drying of Indian borage leaves.Practical applicationsDrying of Indian borage leaves using microwave drying (MD) resulted in quicker drying with retention of bioactive compounds and color of dried leaves. The energy aspects were also favorable for industrial scale‐up. With due consideration to capacity enhancement in MD, it can prove to be a promising source of drying for culinary, medicinal, and aromatic plants.
Inhibition of reactive oxygen species production accompanying alternatively activated microglia by risperidone in a mouse ketamine model of schizophrenia
Authors: Fujikawa Risako , Yamada Jun , Maeda Shoichiro , Iinuma Kyoko M. , Moriyama Genki , Jinno Shozo 
Published: May 2024

AbstractRecent studies have highlighted the potential involvement of reactive oxygen species (ROS) and microglia, a major source of ROS, in the pathophysiology of schizophrenia. In our study, we explored how the second‐generation antipsychotic risperidone (RIS) affects ROS regulation and microglial activation in the hippocampus using a mouse ketamine (KET) model of schizophrenia. KET administration resulted in schizophrenia‐like behaviors in male C57BL/6J mice, such as impaired prepulse inhibition (PPI) of the acoustic startle response and hyper‐locomotion. These behaviors were mitigated by RIS. We found that the gene expression level of an enzyme responsible for ROS production (Nox2), which is primarily associated with activated microglia, was lower in KET/RIS‐treated mice than in KET‐treated mice. Conversely, the levels of antioxidant enzymes (Ho‐1 and Gclc) were higher in KET/RIS‐treated mice. The microglial density in the hippocampus was increased in KET‐treated mice, which was counteracted by RIS. Hierarchical cluster analysis revealed three morphological subtypes of microglia. In control mice, most microglia were resting‐ramified (type I, 89.7%). KET administration shifted the microglial composition to moderately ramified (type II, 44.4%) and hyper‐ramified (type III, 25.0%). In KET/RIS‐treated mice, type II decreased to 32.0%, while type III increased to 34.0%. An in vitro ROS assay showed that KET increased ROS production in dissociated hippocampal microglia, and this effect was mitigated by RIS. Furthermore, we discovered that a NOX2 inhibitor could counteract KET‐induced behavioral deficits. These findings suggest that pharmacological inhibition of ROS production by RIS may play a crucial role in ameliorating schizophrenia‐related symptoms. Moreover, modulating microglial activation to regulate ROS production has emerged as a novel avenue for developing innovative treatments for schizophrenia.image
Exploring the kynurenine pathway in mild traumatic brain injury: A longitudinal study
Authors: Visser Koen , Ciubotariu Diana , de Koning Myrthe E. , Jacobs Bram , van Faassen Martijn , van der Ley Claude , Mayer Andrew R. , Meier Timothy B. , Bourgonje Arno R. , Kema Ido P. , van Goor Harry , van der Naalt Joukje , van der Horn Harm J. 
Published: May 2024

AbstractA potential source of novel biomarkers for mTBI is the kynurenine pathway (KP), a metabolic pathway of tryptophan (Trp), that is up‐regulated by neuroinflammation and stress. Considering that metabolites of the KP (kynurenines) are implicated in various neuropsychiatric diseases, exploration of this pathway could potentially bridge the gap between physiological and psychological factors in the recovery process after mTBI. This study, therefore, set out to characterize the KP after mTBI and to examine associations with long‐term outcome. Patients were prospectively recruited at the emergency department (ED), and blood samples were obtained in the acute phase (<24 h; N = 256) and at 1‐month follow‐up (N = 146). A comparison group of healthy controls (HC; N = 32) was studied at both timepoints. Trp, kynurenines, and interleukin (IL)‐6 and IL‐10 were quantified in plasma. Clinical outcome was measured at six months post‐injury. Trp, xanthurenic acid (XA), and picolinic acid (PA) were significantly reduced in patients with mTBI relative to HC, corrected for age and sex. For Trp (d = −0.57 vs. d = −0.29) and XA (d = −0.98 vs. d = −0.32), larger effects sizes were observed during the acute phase compared to one‐month follow‐up, while for PA (d = −0.49 vs. d = −0.52) effect sizes remained consistent. Findings for other kynurenines (e.g., kynurenine, kynurenic acid, and quinolinic acid) were non‐significant after correction for multiple testing. Within the mTBI group, lower acute Trp levels were significantly related to incomplete functional recovery and higher depression scores at 6 months post‐injury. No significant relationships were found for Trp, XA, and PA with IL‐6 or IL‐10 concentrations. In conclusion, our findings indicate that perturbations of the plasma KP in the hyperacute phase of mTBI and 1 month later are limited to the precursor Trp, and glutamate system modulating kynurenines XA and PA. Correlations between acute reductions of Trp and unfavorable outcomes may suggest a potential substrate for pharmacological intervention.image
Genotype–phenotype correlations of AR‐CMT2S in a cohort of axonal Charcot–Marie–Tooth patients from Central South China
Authors: Liu Lei , Zeng Sen , Li Xiaobo , Xie Yongzhi , Xu Ke , Yang Honglan , Huang Shunxiang , Zhao Huadong , Zhang Ruxu 
Published: May 2024

AbstractBackground and AimsThis study aimed to report nine Charcot–Marie–Tooth disease (CMT) families with six novel IGHMBP2 mutations in our CMT2 cohort and to summarize the genetic and clinical features of all AR‐CMT2S patients reported worldwide.MethodsGeneral information, clinical and neurophysiological data of 275 axonal CMT families were collected. Genetic screening was performed by inherited peripheral neuropathy related genes panel or whole exome sequencing. The published papers reporting AR‐CMT2S from 2014 to 2023 were searched in Pubmed and Wanfang databases.ResultsIn our CMT2 cohort, we detected 17 AR‐CMT2S families carrying IGHMBP2 mutations and eight were published previously. Among these, c.743 T > A (p.Val248Glu), c.884A > G (p.Asp295Gly), c.1256C > A (p.Ser419*), c.2598_2599delGA (p.Lys868Sfs*16), c.1694_1696delATG (p.Asp565del) and c.2509A > T (p.Arg837*) were firstly reported. These patients prominently presented with early‐onset typical axonal neuropathy and without respiratory dysfunction. So far, 56 AR‐CMT2S patients and 57 different mutations coming from 43 families have been reported in the world. Twenty‐nine of 32 missense mutations were clustered in helicase domain and ATPase region. The age at onset ranged from 0.11to 20 years (Mean ± SD: 3.43 ± 3.88 years) and the majority was infantile‐onset (<2 years). The initial symptoms included weakness of limbs (19, 29.7%), delayed milestones (12, 18.8%), gait disturbance (11, 17.2%), feet deformity (8, 12.5%), feet drop (8, 12.5%), etc.InterpretationAR‐CMT2S accounted for 6.2% in our CMT2 cohort. We firstly reported six novel IGHMBP2 mutations which expanded the genotypic spectrum of AR‐CMT2S. Furthermore, 17 AR‐CMT2S families could provide more resources for natural history study, drug research and development.
The Paradox of Inclusion in Elite Workforce Differentiation Practices: Harnessing the Genius Effect
Authors: van Zelderen Anand P. A. , Dries Nicky , Marescaux Elise 
Published: May 2024

AbstractWe examine the assumption that making workforce differentiation practices more inclusive will cause employees to react more positively. We identify a fundamental ‘paradox of inclusion’, where practices designed to be more inclusive may in fact decrease employees' perceived inclusion. Drawing on social comparison theory and the ‘genius effect’ – using talent management practices as an empirical case – we found that both employees identified as ‘talents’ and ‘non‐talents’ reacted more favourably to exclusive, secretive practices than to inclusive, transparent practices. Across four studies, we ran experiments testing managers' assumptions about employee reactions to talent practices (Study 1; N = 179); the reactions of ‘non‐talents’ (Study 2; N = 576); the reactions of ‘talents’ (Study 3; N = 306); and conducted a field study (Study 4; N = 402). Managers' preferences for more inclusive practices were guided by their assumption that non‐talents would react more positively to them. Non‐talents, in fact, reacted morenegativelyto more inclusive practices in terms of envy, organization‐based self‐esteem, turnover intentions, and perceived inclusion. Keeping talent status a secret from employees buffered negative reactions. Based on these findings, we identify paradoxes inherent to workforce differentiation and extend theorizing on the tension between exclusive and inclusive practices within organizations.
A personal exploration of oral health in Parkinson's disease through the eyes of a multifaceted authority
Authors: Verhoeff Merel C. , Raphael Karen G. , Lobbezoo Frank 
Published: May 2024

AbstractBackground and ObjectiveParkinson's disease (PD) poses a range of challenges, including oral health issues, that significantly impact the patient's quality of life. Despite growing awareness of PD, oral health receives limited attention. To shed light on this matter, this personal scoping review explores the perspectives of Professor K.G. Raphael, who is both a professional and a PD patient, on various aspects of oral health in PD.MethodsThrough semi‐structured interviews, Prof. Raphael shares her insights on the complexities of oral health as a PD patient to compose an agenda for oral health care, research, and education, for PD patients.ResultsShe emphasises the importance of interdisciplinary collaboration and education. Additionally, Prof. Raphael identifies crucial research areas, such as exploring the role of the oral microbiome and assessing the impact of exercise on oral health in PD.ConclusionThis study resulted in agendas to improve oral health care, research and education, advocating for a holistic approach to enhance PD patients' well‐being. Despite its limitations, this study highlights the imperative of integrating oral health into the broader management of PD, emphasising interdisciplinary collaboration and patient empowerment.