bluuebunny/crossref_metadata_2025_split huggingface dataset:
DNA‐Binding Small‐Ligand‐Immobilized Surface Plasmon Resonance Biosensor for Detecting Thymine‐Related Single‐Nucleotide Polymorphisms
Authors: Miura Sara , Nishizawa Seiichi , Suzuki Akinori , Fujimoto Yukiko , Ono Katsuya , Gao Qiang , Teramae Norio 
Published: November 2011

AbstractA surface plasmon resonance (SPR) biosensor that carries DNA‐binding small ligands has been developed for the detection of single‐nucleotide polymorphisms (SNPs). 3,5‐Diaminopyrazine derivatives, with a hydrogen‐bonding profile fully complementary to the thymine base, were utilized as recognition elements on the sensor surface, and a target single‐stranded DNA sequence was hybridized with a DNA probe containing an abasic site to place this site opposite a nucleobase to be detected. In a continuous flow of sample solutions buffered to pH 6.4 (0.25 M NaCl), the 3,5‐diaminopyrazine‐based SPR sensor can detect an orphan nucleobase in the duplex with a clear selectivity for thymine over cytosine, guanine, and adenine (5’‐GTT GGA GCT GXG GGC GTA GGC‐3’/3’‐CAA CCT CGA CNC CCG CAT CCG‐5’; X=abasic site, N=target nucleobase G, C, A, or T). The SPR response was linear in the concentration range 10–100 nM. Allele discrimination is possible based on the combination of different binding surfaces in a flow cell of the SPR system, which is demonstrated for the analysis of the thymine/cytosine mutation present in 63‐meric polymerase chain reaction (PCR) amplification products (Ha‐ras gene, codon 12, antisense strand). Comparison with a bulk assay based on 3,5‐diaminopyrazine/DNA binding shows that the immobilization of 3,5‐diaminopyrazine derivatives on the SPR sensor allows more sensitive detection of the target DNA sequence, and binding selectivity can be tuned by controlling the salt concentration of sample solutions. These features of the DNA‐binding small‐molecule‐immobilized SPR sensor are discussed as a basis for the design of SPR biosensors for SNP genotyping.
Different Rearrangement Behaviour of the Cation or Anion Derived from the Diels–Alder Adduct of 9‐Ferrocenylanthracene and 1,4‐Benzoquinone: Ring‐Opening or Paddlewheel Formation
Authors: Nikitin Kirill , Müller‐Bunz Helge , Ortin Yannick , McGlinchey Michael J. 
Published: November 2011

AbstractPrototropic rearrangement of the Diels–Alder adduct (3 a) of 9‐ferrocenylanthracene and 1,4‐benzoquinone potentially furnishes 9‐ferrocenyl‐1,4‐dihydroxytriptycene (3 b) incorporating aC2vsymmetrical paddlewheel moiety. However, reaction of3 awith HBF4unexpectedly yields instead 9‐ferrocenyl‐10‐(2,5‐dihydroxyphenyl)anthracene (4) via cleavage of the C9C12 bond to generate initially a ferrocenyl‐stabilized cation. Treatment of3 awith sodium hydride and iodomethane yields 1,4‐dimethoxy‐9‐ferrocenyltriptycene (3 c) in high yield but, surprisingly, also leads to fission of the C9C12 bond resulting, after methylation, in the formation of 9‐hydroxy‐9‐ferrocenyl‐10‐(2‐hydroxy‐5‐methoxyphenyl)dihydroanthracene (12), which readily dehydrates on silica to form 9‐ferrocenyl‐10‐(2‐hydroxy‐5‐methoxyphenyl)anthracene (8). The X‐ray crystal structures of3 a,3 cand4are reported.
ChemInform Abstract: Direct Correlation Between Nitrogen Chemisorption and Ammonia Synhesis Activity of Ruthenium Catalysts Supported on Carbon Covered Alumina ( CCA).
Authors: MASTHAN S. K. , PRASAD P. S. S. , RAO K. S. R. , RAO P. K. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Diels‐Alder Reactions of Cyclopentadiene with N‐Crotonoyl‐1, 3‐oxazolidin‐2‐one Derivatives Mediated by Chiral Lewis Acids.
Authors: CHAPUIS C. , BAUER T. , JEZEWSKI A. , JURCZAK J. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Extended Linear Aromatics Using Tandem Diels‐Alder Aromatization Reactions.
Authors: MORRIS J. L. , BECKER C. L. , FRONCZEK F. R. , DALY W. H. , MCLAUGHLIN M. L. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photolysis of 3‐Chloro‐3‐aryldiazirines in the Presence of Amines and Allyl Alcohol.
Authors: LIU M. T. H. , ROMASHIN Y. N. , VENKATACHALAM T. K. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3,3‐Dicyclopropyl‐1,2‐dioxetanes: Unusual Temperature Effect on the Singlet Oxygenation of 1,1‐Dialkylethylenes.
Authors: MATSUMOTO M. , SUGANUMA H. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,3‐Asymmetric Induction in the Aldol Addition Reactions of Methyl Ketone Enolates and Enolsilanes to β‐Substituted Aldehydes. A Model for Chirality Transfer.
Authors: EVANS D. A. , DUFFY J. L. , DART M. J. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 1,3‐Asymmetric Induction in Hydride Addition Reactions to β‐ Substituted Ketones. A Model for Chirality Transfer.
Authors: EVANS D. A. , DART M. J. , DUFFY J. L. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Titanium‐Mediated Reaction of Cycloheptatriene with Aldehydes: A New “ Electron‐Reversed” Approach to the Functionalization of Seven‐Membered Ring.
Authors: SZYMONIAK J. , FELIX D. , MOISE C. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Addition of Organolithium Reagents to Imines.
Authors: DENMARK S. E. , NAKAJIMA N. , NICAISE O. J.‐C. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Spectra of Tetrachlorotetraazaporphins
Authors: KHELEVINA O. G. , TIMOFEEVA S. V. , BEREZIN B. D. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Synthesis of Isoindoline and Isoquinoline Derivatives Using Nickel(0)‐Catalyzed (2 + 2 + 2) Cocyclization.
Authors: SATO Y. , NISHIMATA T. , MORI M. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cycloaddition Reactions of Some Dithienopyridines and Their Methylides with Dimethyl Acetylenedicarboxylate.
Authors: TEMCIUC E. , HOERNFELDT A.‐B. , GRONOWITZ S. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Addition of Carbonyl Compounds to Tetramesitylgermasilene and Dimesitylgermylene.
Authors: BAINES K. M. , COOKE J. A. , VITTAL J. J. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tri‐ and Tetra‐Peptides Incorporating an α‐Amino Acid at the Anomeric Position of Mannofuranose.
Authors: ESTEVEZ J. C. , ESTEVEZ R. J. , ARDRON H. , WORMALD M. R. , BROWN D. , FLEET G. W. J. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the A/E/F Tricyclic Section of the Norditerpenoid Alkaloid Methyllycaconitine, a Potent Inhibitor of Neurotransmission.
Authors: BAILLIE L. C. , BEARDER J. R. , WHITING D. A. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of Michellamines A‐C: Important anti‐HIV Agents.
Authors: HOYE T. R. , CHEN M. , MI L. , PRIEST O. P. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Bromoxone.
Authors: GAUTIER E. C. L. , LEWIS N. J. , MCKILLOP A. , TAYLOR R. J. K. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Properties of Multifunctional Poly(2‐trimethylsilyl‐1,4‐ phenylenevinylene): A Novel, Silicon‐Substituted, Soluble PPV Derivative
Authors: HWANG D.‐H. , SHIM H.‐K. , LEE J.‐I. , LEE K.‐S. 
Published: November 2011

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling Heterogeneous Catalyzed Reactions in Porous Media
Authors: Keil Frerich J. 
Published: November 2011

AbstractEntwicklungen in der Modellierung heterogen‐katalytischer Prozesse, speziell quantenchemische Methoden für die Berechnung der Reaktionen am aktiven Zentrum und die Theorie des Übergangszustandes, werden dargestellt. Hinzu kommen die Beschreibung der Multikomponentendiffusion und Adsorption in den Poren der Katalysatorträger unter besonderer Berücksichtigung dieser Phänomene in Zeolithen. Abschließend wird die Optimierung von Porenstrukturen in Katalysatorträgern hinsichtlich vorgegebener Kriterien behandelt.
A Structural Investigation of Dimethylthallium(III) Thiolate and Selenolate Rings and Polymers
Authors: Briand Glen G. , Decken Andreas , Hunter Nicole M. , Wright John A. , Zhou Y. 
Published: November 2011

AbstractThe effects of increased steric bulk in dimethylthallium(III) chalcogenolates on oligomerization was examined. The facile reaction of Me3Tl with a series of benzenethiols and ‐selenols in toluene or thf resulted in the formation of [Me2TlS(2,6‐Me2C6H3)]∞ (2), [Me2TlS(2,4,6‐tBu3C6H2)]∞ (3), [Me2TlSe(C6H5)]2 (4), [Me2TlSe(2,4,6‐Me3C6H2)]∞ (5), and [Me2TlSe(2,4,6‐tBu3C6H2)]∞ (6). The solid‐state structure of 4 is dimeric with short intermolecular Tl···Se interactions, which yields an asymmetric Tl2Se2 core and a distorted tetrahedral C2Se2 bonding environment for the thallium. The increase in the steric bulk of the chalcogenolate ligand in compounds 2 and 5 results in the formation of polymeric structures with μ‐E[2,(4),6‐Me3C6H2] (E = S, Se) groups and distorted tetrahedral C2E2 bonding environments for the thallium. A further increase in the steric bulk of the phenylchalcogenolate resulted in the formation of chains of weakly coordinated monomers by means of the intermolecular Tl···E interactions in 3 (E = S) and 6 (E = Se). This work represents the first systematic study of diorganothallium thiolates and selenolates and compounds 4–6 represent the first structurally characterized examples of R2TlSeR′ species. A comparison of the structures of [Me2TlS(C6H5)]2 (1) and 2–6 with other group 13 analogue structures suggests that the degree of oligomerization differs for [Me2MSR′]n (M = Tl) versus the analogous (M = Al, Ga, and In) species. These findings areimportant in understanding the factors that govern oligomerization (i.e. ring size) and polymerization of diorganotriel chalcogenolates.
A H2/O2 Fuel Cell for In situ μ‐Raman Measurements. In‐depth Characterization of an Ionic Liquid Filled Nafion Membrane
Authors: Martinelli A. , Iojoiu C. , Sergent N. 
Published: November 2011

AbstractWe report the design of a H2/O2 (fuel) cell for in situ μ‐Raman spectroscopic measurements. The horizontal orientation of the cell is conceived to allow the penetration of the laser beam along the z‐axis from one electrode to the other. We show that during in‐depth analyses the Raman signal is not significantly lost and the axial resolution is sufficiently good to allow quantitative and qualitative spectral interpretation. We report “proof of principle” tests performed on Nafion membranes swelled with protic ionic liquids to demonstrate the validity of the design and the potentiality of the method. Our results confirm that this experimental setup can efficiently be used to follow structural changes and concentration gradients in the electrolyte of a fuel cell operando. In particular, we have been able to resolve both in time and in space the hydration state of the membrane as well as spatial variations for the $ {\rm SO}_3^- $ coordination shell during a compositional transient state.
Relationship between paraglottic space invasion and cervical lymph node metastasis in patients undergoing supracricoid partial laryngectomy
Authors: Joo Young‐Hoon , Park Jun‐Ook , Cho Kwang‐Jae , Kim Min‐Sik 
Published: November 2011

AbstractBackgroundTo investigate the relationship between paraglottic space (PGS) invasion and lymph node metastasis in patients undergoing supracricoid partial laryngectomy.MethodsThe study included 98 subjects with squamous cell carcinoma of the glottis.ResultsThe PGS invasion rate was 60.2% (59/98), and a significant correlation was found between PGS invasion and cervical lymph node metastasis (p = .022). Fifteen of the 59 patients (25.4%) with PGS invasion, only 3 of the 39 patients (7.7%) without any evidence of PGS invasion had lymph node metastasis. Furthermore, a significant correlation was also found between PGS invasion and T classification (p < .001), vocal cord mobility (p < .001), and subglottic extension (p = .014), and patients with no evidence of PGS invasion possibly had a survival benefit (5‐year disease‐specific survival rate, 84% vs 64%; p = .118).ConclusionThis study shows that PGS invasion is significantly related to cervical lymph node metastasis in patients undergoing supracricoid partial laryngectomy. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Fear conditioning is disrupted by damage to the postsubiculum
Authors: Robinson Siobhan , Bucci David J. 
Published: November 2011

AbstractThe hippocampus plays a central role in spatial and contextual learning and memory, however relatively little is known about the specific contributions of parahippocampal structures that interface with the hippocampus. The postsubiculum (PoSub) is reciprocally connected with a number of hippocampal, parahippocampal and subcortical structures that are involved in spatial learning and memory. In addition, behavioral data suggest that PoSub is needed for optimal performance during tests of spatial memory. Together, these data suggest that PoSub plays a prominent role in spatial navigation. Currently it is unknown whether the PoSub is needed for other forms of learning and memory that also require the formation of associations among multiple environmental stimuli. To address this gap in the literature we investigated the role of PoSub in Pavlovian fear conditioning. In Experiment 1 male rats received either lesions of PoSub or Sham surgery prior to training in a classical fear conditioning procedure. On the training day a tone was paired with foot shock three times. Conditioned fear to the training context was evaluated 24 hr later by placing rats back into theconditioning chamber without presenting any tones or shocks. Auditory fear was assessed on the third day by presenting the auditory stimulus in a novel environment (no shock). PoSub‐lesioned rats exhibited impaired acquisition of the conditioned fear response as well as impaired expression of contextual and auditory fear conditioning. In Experiment 2, PoSub lesions were made 1 day after training to specifically assess the role of PoSub in fear memory. No deficits in the expression of contextual fear were observed, but freezing to the tone was significantly reduced in PoSub‐lesioned rats compared to shams. Together, these results indicate that PoSub is necessary for normal acquisition of conditioned fear, and that PoSub contributes to the expression of auditory but not contextual fear memory. © 2011 Wiley Periodicals, Inc.
Effect of lipopolysaccharide on alteration of phospholipids and their fatty acid composition in spleen and thymus by in vitro metabolic labeling
Authors: Sabarirajan Jayaraja , Vijayaraj Panneerselvam , Sarkar Mary , Nachiappan Vasanthi 
Published: November 2011

ABSTRACTLipopolysaccharide (LPS) is an endotoxin, a potent stimulator of immune response and induction of LPS leads to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). ARDS is a life‐threatening disease worldwide with a high mortality rate. The immunological effect of LPS with spleen and thymus is well documented; however the impact on membrane phospholipid during endotoxemia has not yet been studied. Hence we aimed to investigate the influence of LPS on spleen and thymus phospholipid and fatty acid composition by [32P]orthophosphate labeling in rats. The in vitro labeling was carried out with phosphate‐free medium (saline). Time course, LPS concentration‐dependent, pre‐ and post‐labeling with LPS and fatty acid analysis of phospholipid were performed. Labeling studies showed that 50 µg LPS specifically altered the major phospholipids, phosphatidylcholine and phosphatidylglycerol in spleen and phosphatidylcholine in thymus. Fatty acid analysis showed a marked alteration of unsaturated fatty acids/saturated fatty acids in spleen and thymus leading to immune impairment via the fatty acid remodeling pathway. Our present in vitro lipid metabolic labeling study could open up new vistas for exploring LPS‐induced immune impairment in spleen and thymus, as well as the underlying mechanism. Copyright © 2011 John Wiley & Sons, Ltd.
Proteomic characterization of the late and persistent effects of cadmium at low doses on the rat liver
Authors: Wang Bo , Wang Shi , Shao Chen , Wang Guangyi , Li Yang , Cai Lu 
Published: November 2011

ABSTRACTTo investigate the late and persistent effects of cadmium (Cd) at low doses on the liver and its potential mechanisms, male Wistar rats were given i.p. injection of Cd as CdCl2 at 20 nmol kg−1 body weight every other day for 4 weeks. At weeks 20, 44 and 52, the livers from Cd‐treated and age‐matched control rats were examined pathologically and biochemically. Chronic exposure of rats to Cd at low doses induced mild pathological changes and persistent oxidative damage as well as cell proliferation. Hepatic proteins were analyzed with two‐dimensional electrophoresis (2‐DE) and mass spectrometry. More than 1000 protein spots were detected by 2‐DE. Ten proteins were distinguishable between Cd‐treated and age‐matched control groups at week 52 week after Cd treatment. Two of them were significantly down‐regulated: prohibitin (PHB) and d‐dopachrome tautomerase (DDT). By western blotting the down‐regulated expression of PHB and DDT in the livers of Cd‐treated rats was confirmed in both early (week 20) and late (week 52) time points. To further examine the down‐regulation of antioxidant status in the Cd‐treated livers, other common antioxidants, including superoxide dismutase and glutathione and one metal detoxification specific protein metallothionein, were also detected and found to be decreased, particularly at the late stage. These results suggest that mild histopathological changes, persistent oxidative damage and cell proliferation remained at the late stages (weeks 44–52) after rats were exposed to low‐dose Cd. These persistent changes may be associated with the persistent down‐regulation of cellular antioxidant systems. Copyright © 2011 John Wiley & Sons, Ltd.
Resonance Raman quantification of the redox state of cytochromes b and cin‐vivo and in‐vitro
Authors: Kakita Minoru , Kaliaperumal Venkatesh , Hamaguchi Hiro‐o 
Published: November 2011

AbstractWe observe the redox state changes with respiration of cytochromes b and c in mitochondria in a living Saccharomyces cerevisiae cell as well as in isolated mitochondria with the very use of Raman microspectroscopy. The possibility of monitoring the respiration activity of mitochondria in vivo and in vitro by Raman microspectroscopic quantification of the cytochrome redox states is suggested. It will lead to a new means to assess mitochondrial respiration activity in vivo and in vitro without using any labelling or genetic manipulation. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)