bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the Rate of Preschool Vision Screening: An Interrupted Time-Series Analysis
Authors: Kemper Alex R. , Helfrich Anya , Talbot Jennifer , Patel Nita , Crews John E. 
Published: October 2011

OBJECTIVE:To implement a 6-month quality improvement project in 13 clinics in North Carolina to improve vision screening rates for children 3 through 5 years of age.METHODS:We trained each clinic in approaches to vision screening and selected champions to provide feedback based on a 3-month baseline chart audit of up to 90 charts in each clinic and then 60 monthly chart audits in each clinic.RESULTS:Overall, the baseline rate of distance vision testing (92%) and stereopsis testing (80%) was high. By the end of the project, there were increases in both the rate of distance vision testing (97%; P &lt; .001) and stereopsis testing (89%; P &lt; .001). Initially, there were many different tests used to assess distance visual acuity and some variation in the thresholds used for referral for eye care. Tests were standardized across clinics by the end of the project. The proportion of all children who were untestable was high throughout the project, including 45% among 3-year-olds by the end of the project. Follow-up rescreening was rarely documented. By the end of the project, only 48% of children with an abnormal screen result were documented to be referred. Within each clinic, concerns about the accuracy of testing persisted throughout the project.CONCLUSIONS:We were successful in standardizing vision testing. Even with training, the proportion of untestable children was high. Rates of documented referral were low, which reflects provider concerns about testing accuracy. New strategies are needed to improve testability and ensure timely referral and follow-up after an abnormal vision screen result.
Effect of Nanocavities on the Thermoelectric Properties of Polycrystalline Silicon
Authors: Selezneva Ekaterina , Arcari Andrea , Pernot Gilles , Romano Elisabetta , Cerofolini Gianfranco , Tonini Rita , Frabboni Stefano , Ottaviani Giampiero , Shakouri Ali , Narducci Dario 
Published: October 2011

ABSTRACTNanostructuring has opened new ways to increase the thermoelectric performance of a host of materials, mainly by decreasing their thermal conductivity κ while preserving the Seebeck coefficient S and electrical conductivity σ. The thermoelectric properties of degenerated polycrystalline silicon films with nanocavities (NCs) have been studied as a function of annealing temperature upon isochronous annealings in argon carried out every 50°C in the range 500 – 1000°C which were used to modify the shape of the NCs. We found that presence of the NCs had no negative effect on the electronic properties of the system. The measured values of S and σ were close to those previously reported for the blank polycrystalline silicon films with the same doping level. The thermal conductivity was also found to be close to the value measured on the blank sample, about half of the reported value in polycrystals. This led to a power factor of 15.2 mWm-1K-2 and a figure of merit of 0.18 at 300 K.
Health-Related Quality of Life Among Long-Term Survivors of Colorectal Cancer: A Population-Based Study
Authors: Caravati-Jouvenceaux Agnès , Launoy Guy , Klein Delphine , Henry-Amar Michel , Abeilard Edwige , Danzon Arlette , Pozet Astrid , Velten Michel , Mercier Mariette 
Published: October 2011

Abstract

Learning Objectives
After completing this course, the reader will be able to: Compare quality of life in long-term colorectal cancer survivors with quality of life in the general population.Identify cancer complications that affect quality of life in long-term colorectal cancer survivors.
CME This article is available for continuing medical education credit at CME.TheOncologist.com

Background.
The number of long-term colorectal cancer survivors is increasing. Cancer and its treatment can cause physical and psychological complications, but little is known about how it impacts quality of life (QOL) over the long term—5, 10, and 15 years after diagnosis.

Methods.
Cancer survivors were randomly selected from three tumor registries in France, diagnosed in 1990 (±1 year), 1995 (±1 year), and 2000 (±1 year). Controls were randomly selected from electoral rolls, stratifying on gender, age group, and residence area. Participants completed two QOL questionnaires, a fatigue questionnaire, an anxiety questionnaire, and a life conditions questionnaire. An analysis of variance was used to compare QOL scores of cancer survivors by period of diagnosis (5, 10, and 15 years) with those of controls, adjusted for sociodemographic data and comorbidities.

Results.
We included 344 colon cancer and 198 rectal cancer survivors and 1,181 controls. In a global analysis, survivors reported a statistically and clinically significant lower score in social functioning 5 years after diagnosis and higher scores in diarrhea symptoms 5 and 10 years after diagnosis. In subgroup analyses, rectal cancer affected QOL in the physical dimensions at 5 years and in the fatigue dimensions at 5 and 10 years.

Conclusion.
Survivors of colorectal cancer may experience the effects of cancer and its treatment up to 10 years after diagnosis, particularly for rectal cancer. Clinicians, psychologists, and social workers must pay special attention to rectal cancer survivors to improve overall management.
Pathogenicity Variation and Mycelial Compatibility Groups in Sclerotinia Sclerotiorum
Authors: Irani Hossein , Heydari Asghar , Javan-Nikkhah Mohammad , İbrahimov Ağav∂li 
Published: October 2011

Pathogenicity Variation and Mycelial Compatibility Groups inSclerotinia SclerotiorumPopulation variability ofS. sclerotiorum, the causal agent of Sclerotinia stalk rot of sunflower, was determined by mycelial compatibility grouping (MCG) and pathogenicity variation comparison. To study mycelial compatibility grouping and pathogenicity variability, isolates ofS. sclerotiorumwere collected from sunflower fields in East, West Azerbaijan and Ardebil provinces of Iran. Among 186 isolates tested, 26 MCGs were identified and 46% were represented by single isolates. There were differences among MCGs comparing mycelial growth rate, sclerotial production on PDA and aggressiveness cause disease. Significant differences were detected in number of sclerotia, dry weight of sclerotia, mycelial growth rate and aggressiveness among MCGs (p < 0.001) regardless of their geographic origins. There was generally a poor correlation (r = 0.21, p ≤ 0.05) between sclerotia weight and number of sclerotia produced on PDA and also to the mycelial growth rate at 24 (r = 0.35, p ≤ 0.05) and 48h (r = 0.39, p ≤ 0.05). Our studies in comparison of the detached leaf and cut-stem methods showed that the highest rank correlations (r = 0.78 p ≤ 0.01), while aggressiveness of two inoculation methods (stem and leaf detached) were not correlated to colony diameter growth or the other two factors. Variation in isolates aggressiveness may be important considerations in disease management systems.
Cell nucleus and membrane recovery after exposure to microwaves
Authors: Shckorbatov Yuriy , Pasiuga Vladimir , Kolchigin Nicolay , Grabina Valentin , Ivanchenko Dmitry , Bykov Victor , Dumin Oleksandr 
Published: October 2011

Cell nucleus and membrane recovery after exposure to microwaves
Cells of human buccal epithelium of six male donors were exposed to microwave radiation (frequency f = 36.64 GHz, power density W = 0.1, 1 and 4 W/m2). Exposure time was 10 seconds. The state of chromatin in cell nucleus was estimated by a number of heterochromatin granules after staining with 2% orcein in 45% acetic acid. Permeability of cell membranes was estimated by percentage of unstained cells after 5 min of staining the cells with vital dyes trypan blue (0.5%) and indigocarmine (5 mM). Cell exposure to microwaves induced chromatin condensation (increase of the number of heterochromatin granules) and increase of membrane permeability to trypan blue and indigocarmine. Isolated human buccal cells demonstrated the ability to recover after microwave exposure. The number of heterochromatin granules decreased to its initial level after 0.5 hour (W = 0.1 W/m2) and 2 hours (W = 1 and 4 W/m2) after cell exposure. Cell plasma membrane permeability recovered later — after 1 hour and 3 hours post exposure, respectively.
Should Whiteheadians Be Vegetarians? A Critical Analysis of the Thoughts of Hartshorne and Dombrowski
Authors: Deckers Jan 
Published: October 2011

Abstract
A number of philosophers have found inspiration in the writings of Alfred Whitehead to develop their ideas on environmental and animal ethics. I explore the writings of Charles Hartshorne and Daniel Dombrowski to address the question of whether Whiteheadians should be vegetarians. I conclude that there is a morally relevant distinction between plants and animals, based on the Whiteheadian view that animals have higher grades of experience, and that this distinction grounds a moral duty to adopt minimal moral veganism.
First Global Consensus for Evidence-Based Management of the Hematopoietic Syndrome Resulting From Exposure to Ionizing Radiation
Authors: Dainiak Nicholas , Gent Robert Nicolas , Carr Zhanat , Schneider Rita , Bader Judith , Buglova Elena , Chao Nelson , Coleman C. Norman , Ganser Arnold , Gorin Claude , Hauer-Jensen Martin , Huff L. Andrew , Lillis-Hearne Patricia , Maekawa Kazuhiko , Nemhauser Jeffrey , Powles Ray , Schünemann Holger , Shapiro Alla , Stenke Leif , Valverde Nelson , Weinstock David , White Douglas , Albanese Joseph , Meineke Viktor 
Published: October 2011

ABSTRACTObjective:Hematopoietic syndrome (HS) is a clinical diagnosis assigned to people who present with ≥1 new-onset cytopenias in the setting of acute radiation exposure. The World Health Organization convened a panel of experts to evaluate the evidence and develop recommendations for medical countermeasures for the management of HS in a hypothetical scenario involving the hospitalization of 100 to 200 individuals exposed to radiation. The objective of this consultancy was to develop recommendations for treatment of the HS based upon the quality of evidence.Methods:English-language articles were identified in MEDLINE and PubMed. Reference lists of retrieved articles were distributed to panel members before the meeting and updated during the meeting. Published case series and case reports of individuals with HS, published randomized controlled trials of relevant interventions used to treat nonirradiated individuals, reports of studies in irradiated animals, and prior recommendations of subject matter experts were selected. Studies were extracted using the Grading of Recommendations Assessment Development and Evaluation (GRADE) system. In cases in which data were limited or incomplete, a narrative review of the observations was made. No randomized controlled trials of medical countermeasures have been completed for individuals with radiation-associated HS. The use of GRADE analysis of countermeasures for injury to hematopoietic tissue was restricted by the lack of comparator groups in humans. Reliance on data generated in nonirradiated humans and experimental animals was necessary.Results:Based upon GRADE analysis and narrative review, a strong recommendation was made for the administration of granulocyte colony-stimulating factor or granulocyte macrophage colony-stimulating factor and a weak recommendation was made for the use of erythropoiesis-stimulating agents or hematopoietic stem cell transplantation.Conclusions:Assessment of therapeutic interventions for HS in humans exposed to nontherapeutic radiation is difficult because of the limits of the evidence.(Disaster Med Public Health Preparedness. 2011;5:202-212)
Literature Review and Global Consensus on Management of Acute Radiation Syndrome Affecting Nonhematopoietic Organ Systems
Authors: Dainiak Nicholas , Gent Robert Nicolas , Carr Zhanat , Schneider Rita , Bader Judith , Buglova Elena , Chao Nelson , Coleman C. Norman , Ganser Arnold , Gorin Claude , Hauer-Jensen Martin , Huff L. Andrew , Lillis-Hearne Patricia , Maekawa Kazuhiko , Nemhauser Jeffrey , Powles Ray , Schünemann Holger , Shapiro Alla , Stenke Leif , Valverde Nelson , Weinstock David , White Douglas , Albanese Joseph , Meineke Viktor 
Published: October 2011

ABSTRACTObjectives:The World Health Organization convened a panel of experts to rank the evidence for medical countermeasures for management of acute radiation syndrome (ARS) in a hypothetical scenario involving the hospitalization of 100 to 200 victims. The goal of this panel was to achieve consensus on optimal management of ARS affecting nonhematopoietic organ systems based upon evidence in the published literature.Methods:English-language articles were identified in MEDLINE and PubMed. Reference lists of retrieved articles were distributed to conferees in advance of and updated during the meeting. Published case series and case reports of ARS, publications of randomized controlled trials of relevant interventions used to treat nonirradiated individuals, reports of studies in irradiated animals, and prior recommendations of subject matter experts were selected. Studies were extracted using the Grading of Recommendations Assessment Development and Evaluation system. In cases in which data were limited or incomplete, a narrative review of the observations was made.Results:No randomized controlled trials of medical countermeasures have been completed for individuals with ARS. Reports of countermeasures were often incompletely described, making it necessary to rely on data generated in nonirradiated humans and in experimental animals. A strong recommendation is made for the administration of a serotonin-receptor antagonist prophylactically when the suspected exposure is >2 Gy and topical steroids, antibiotics, and antihistamines for radiation burns, ulcers, or blisters; excision and grafting of radiation ulcers or necrosis with intractable pain; provision of supportive care to individuals with neurovascular syndrome; and administration of electrolyte replacement therapy and sedatives to individuals with significant burns, hypovolemia, and/or shock. A strong recommendation is made against the use of systemic steroids in the absence of a specific indication. A weak recommendation is made for the use of fluoroquinolones, bowel decontamination, loperamide, and enteral nutrition, and for selective oropharyngeal/digestive decontamination, blood glucose maintenance, and stress ulcer prophylaxis in critically ill patients.Conclusions:High-quality studies of therapeutic interventions in humans exposed to nontherapeutic radiation are not available, and because of ethical concerns regarding the conduct of controlled studies in humans, such studies are unlikely to emerge in the near future.(Disaster Med Public Health Preparedness. 2011;5:183–201)
Risk‐sensitive filtering for nonlinear Markov jump systems on the basis of particle approximation
Authors: Zhao Shunyi , Liu Fei , Luan Xiaoli 
Published: October 2011

SUMMARYIn this paper, the risk‐sensitive filtering method that relaxes the dependence on model accuracy is extended to nonlinear Markov jump systems (MJSs). In the method, the so‐called reference probability technique together with particle approximation is utilized to derive the risk‐sensitive filter in nonlinear non‐Gaussian framework. The novelty of the proposed approach is that a ‘risky’ interacting resampling step is performed to both moderate the modeling uncertainties and to solve the problem of particle explosion. A designer‐chosen parameter named risk‐sensitive parameter allows us to make a trade‐off between the filtering accuracy for the nominal model and the robustness to uncertainties. With a meaningful example, it shows that the developed method can outperform the widely used method‐particle filter and interacting multiple model‐particle filter in nonlinear MJSs with uncertainties. Copyright © 2011 John Wiley & Sons, Ltd.
Hydrogenation of dimethyl oxalate to ethylene glycol on a Cu/SiO2/cordierite monolithic catalyst: Enhanced internal mass transfer and stability
Authors: Yue Hairong , Zhao Yujun , Zhao Li , Lv Jing , Wang Shengping , Gong Jinlong , Ma Xinbin 
Published: October 2011

AbstractThe design and application of a Cu/SiO2‐based monolithic catalyst for hydrogenation of dimethyl oxalate (DMO) to ethylene glycol (EG) is presented. The catalyst was dip‐coated on cordierite with highly dispersed Cu/SiO2 slurry prepared by ammonia evaporation method. This structure guarantees high dispersion of copper species within the mesopores of silica matrix in the form of copper phyllosilicate. The catalyst is low cost, stable, and exhibits high activity in the reaction of hydrogenation of DMO, achieving a 100% conversion of DMO and more than 95% selectivity to EG. Notably, STYEG over the monolith is significantly enhanced compared to the packed bed Cu/SiO2 catalysts in both forms of pellet and cylinder. It is primarily due to the relatively short diffusive pathway of the thin wash‐coat layer and high efficiency of the active phase derived from the monolithic catalyst. Theoretical results indicated that the internal mass transfer is dominated on the catalysts of pellet and cylinders. Moreover, the monolithic catalyst possessed excellent thermal stability compared to the pellet catalyst, which is attributed to the regular channel structure, uniform distribution of flow. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Using the attainable region analysis to determine the effect of process parameters on breakage in a ball mill
Authors: Metzger Matthew J. , Desai Sachin P. , Glasser David , Hildebrandt Diane , Glasser Benjamin J. 
Published: October 2011

AbstractBall milling is one of the most common unit operations used for size reduction across a range of industries. However, it is also a notoriously inefficient process, often contributing substantially to operational costs. In this work, we investigate the influence of rotation rate, grinding media fill level and grinding media size on the optimal production of a product of intermediate size. We find that changing the grinding media size at otherwise identical conditions produces different breakage products as well as nonmonotonic trends with varying rotation rate and grinding media fill levels. In addition, we show how to use the attainable region analysis to explore the parameter space in a reduced time without having to perform tests at every parameter combination. Finally, we examine how the complex interplay between rotation rate, grinding media fill level and grinding media size can control the mechanism of breakage occurring inside a ball mill. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Chromosomal anomalies in the etiology of anorectal malformations: A review
Authors: Marcelis Carlo , de Blaauw Ivo , Brunner Han 
Published: October 2011

AbstractAnorectal malformation (ARM) is a severe congenital anomaly that can occur either isolated or in association with other congenital abnormalities. It has a heterogeneous etiology with contribution of both genetic and environmental factors, although the etiological factors remain largely unknown. Several chromosomal abnormalities have been described in patients with an ARM. These chromosomal abnormalities could point to specific genes involved in the development of the anorectal canal and associated structures. This paper reviews the chromosomal abnormalities described in ARM and may act as a starting point to identify chromosomal regions containing putative anorectal development genes. © 2011 Wiley Periodicals, Inc.
Adrenal function in Smith–Lemli–Opitz syndrome
Authors: Bianconi Simona E. , Conley Sandra K. , Keil Meg F. , Sinaii Ninet , Rother Kristina I. , Porter Forbes D. , Stratakis Constantine A. 
Published: October 2011

AbstractSmith–Lemli–Opitz syndrome (SLOS) is a multiple malformation syndrome due to mutations of the 7‐dehydrocholesterol reductase gene (DHCR7), which leads to a deficiency of cholesterol synthesis and an accumulation of 7‐dehydrocholesterol. The SLOS clinical spectrum ranges from multiple major malformations to a mild phenotype with minor anomalies and intellectual disability. Several children with SLOS and adrenal insufficiency have been described. We performed ovine corticotropin (oCRH) testing in 35 SLOS patients and 16 age‐ and gender‐matched controls. We reviewed prior adrenocorticotropin (ACTH) stimulation tests of our SLOS patients (19 of 35 available) and reviewed results of ACTH stimulation tests from 10 additional SLOS patients. Results from oCRH testing showed that patients with SLOS had significantly higher ACTH baseline values than healthy controls (24.8 ± 15.3 pg/ml vs. 17.8 ± 7.5 pg/ml, P = 0.034). However, no statistically significant differences were noted for peak ACTH values (74.4 ± 35.0 pg/ml vs. 64.0 ± 24.9 pg/ml, P = 0.303) and for baseline (14.2 ± 7.8 mcg/dl vs. 14.2 ± 6.3 mcg/dl, P = 0.992) and peak cortisol values (28.2 ± 7.9 mcg/dl vs. 24.8 ± 8.1 mcg/dl, P = 0.156). The area‐under‐the‐curve (AUC) was not significantly different in SLOS patients compared to controls for both ACTH (250.1 ± 118.7 pg/ml vs. 195.3 ± 96.6 pg/ml, P = 0.121) as well as cortisol secretion (83.1 ± 26.1 mcg/dl vs. 77.8 ± 25.9 mcg/dl, P = 0.499). ACTH stimulation test results were normal in 28 of 29 tests. The individual with the abnormal test results had subsequent normal oCRH tests. The slightly increased baseline ACTH level seen during oCRH testing may be due to compensated adrenocortical insufficiency. However, we were able to show that our patients with SLOS had an adequate glucocorticoid response, and thus, in mild to moderate cases of SLOS stress steroid coverage may not be warranted. Published 2011. This article is a U.S. Government work and is in the public domain in the USA.
Natural outcome of trisomy 13, trisomy 18, and triploidy after prenatal diagnosis
Authors: Lakovschek Ioana Claudia , Streubel Berthold , Ulm Barbara 
Published: October 2011

AbstractTrisomy 13, trisomy 18, and triploidy belong to the chromosomal abnormalities which are compatible with life, but which are also associated with a high rate of spontaneous abortion, intrauterine death, and a short life span. This study was conducted to analyze natural outcome after prenatal diagnosis of these disorders. Between January 1, 1999 and December 31, 2009, we investigated all amniocenteses and chorionic villus biopsies carried out at our department. All cases with fetal diagnosis of triploidy, trisomy 13, and 18 were analyzed, with a focus on cases with natural outcome. Overall, 83 (78%) cases of pregnancy termination and 24 (22%) patients with natural outcome (NO) were identified. The NO group included 15 cases of trisomy 18, six cases of triploidy, and three cases of trisomy 13. No case of triploidy was born alive. The live birth rate was 13% for trisomy 18 and 33% for trisomy 13. The three live‐born infants with trisomy 13 and 18 died early after a maximum of 87 hr postpartum. Our data are consistent with the literature concerning outcome of triploidy, with none or only a few live births. Analyzes of trisomy 13 and 18 indicate a very short postnatal life span. Different study designs and diverse treatment strategies greatly affect the fetal and neonatal outcome of fetuses with triploidy, trisomy 13, and 18. More studies analyzing natural outcome after prenatal diagnosis of these chromosomal abnormalities are needed. Non‐termination of these pregnancies remains an option, and specialists advising parents need accurate data for counseling. © 2011 Wiley Periodicals, Inc.