bluuebunny/crossref_metadata_2025_split huggingface dataset:
Executive function deficits in genetic frontotemporal dementia: results from the GENFI study
Authors: Russell Lucy L , Bouzigues Arabella , Convery Rhian S , Foster Phoebe , Ferry-Bolder Eve , Cash David M. , van Swieten John C. , Jiskoot Lize C. , Seelaar Harro , Moreno Fermin , Sanchez-Valle Raquel , Laforce Robert , Graff Caroline , Masellis Mario , Tartaglia Maria Carmela , Rowe James B. , Borroni Barbara , Finger Elizabeth , Synofzik Matthis , Galimberti Daniela , Vandenberghe Rik , de Mendonça Alexandre , Butler Chris , Gerhard Alexander , Ducharme Simon , Le Ber Isabelle , Santana Isabel , Pasquier Florence , Levin Johannes , Sorbi Sandro , Otto Markus , Rohrer Jonathan D. 
Published: May 2024

AbstractBackgroundExecutive dysfunction is a core feature of frontotemporal dementia (FTD). Whilst there has been extensive research into such impairments in sporadic FTD, there has been little research in the familial forms.Methods752 individuals were recruited in total: 214C9orf72, 205GRNand 86MAPTmutation carriers, stratified into asymptomatic, prodromal and fully symptomatic, and 247 mutation negative controls. Attention and executive function were measured using the Weschler Memory Scale-Revised (WMS-R) Digit Span Backwards (DSB), the Wechsler Adult Intelligence Scale-Revised Digit Symbol task, the Trail Making Test Parts A and B, the Delis-Kaplan Executive Function System Color Word Interference Test and verbal fluency tasks (letter and category). Linear regression models with bootstrapping were used to assess differences between groups. Correlation of task score with disease severity was also performed, as well an analysis of the neuroanatomical correlates of each task.ResultsFully symptomaticC9orf72, GRNandMAPTmutation carriers were significantly impaired on all tasks compared with controls (all p<0.001), except on the WMS-R DSB in theMAPTmutation carriers (p=0.147). Whilst asymptomatic and prodromalC9orf72individuals also demonstrated deficits compared with controls, neither theGRNorMAPTasymptomatic or prodromal mutation carriers showed significant differences. All tasks significantly correlated with disease severity in each of the genetic groups (all p<0.001).ConclusionsIndividuals withC9orf72mutations show difficulties with executive function from very early on in the disease and this continues to deteriorate with disease severity. In contrast, similar difficulties occur only in the later stages of the disease inGRNandMAPTmutation carriers. This differential performance across the genetic groups will be important in neuropsychological task selection in upcoming clinical trials.
Left-right-alternating theta sweeps in the entorhinal-hippocampal spatial map
Authors: Vollan Abraham Z. , Gardner Richard J. , Moser May-Britt , Moser Edvard I. 
Published: May 2024

AbstractPlace cells in the hippocampus and grid cells in the entorhinal cortex are elements of a neural map of self-position1–5. To benefit navigation, this representation must be dynamically related to surrounding locations2. A candidate mechanism for linking places along an animal’s path has been described in place cells, where the sequence of spikes within each cycle of the hippocampal theta oscillation encodes a trajectory from the animal’s current location towards upcoming locations6–8. In mazes that bifurcate, such trajectories alternately traverse the two upcoming arms as the animal approaches the choice point9,10, raising the possibility that the trajectories express available forward paths encoded on previous trials10. However, to bridge the animal’s path with the wider environment, beyond places previously or subsequently visited, an experience-independent spatial sampling mechanism might be required. Here we show in freely moving rats, that within individual theta cycles, ensembles of grid cells and place cells encode a position signal that sweeps linearly outwards from the animal’s location into the ambient environment, with sweep direction alternating stereotypically between left and right across successive theta cycles. These sweeps were accompanied by, and aligned with, a similarly alternating directional signal in a discrete population of parasubiculum cells with putative connections to grid cells via conjunctive grid×direction cells. Sweeps extended into never-visited locations that were inaccessible to the animal and persisted during REM sleep. Sweep directions could be explained by an algorithm that maximizes cumulative coverage of surrounding space. The sustained and unconditional expression of theta-patterned left-right-alternating sweeps in the entorhinal-hippocampal positioning system provides an efficient ‘look-around’ mechanism for sampling locations beyond the travelled path.
Differential modulation of sensory response dynamics by cilia structure and intraflagellar transport within and across chemosensory neurons
Authors: Philbrook Alison , O’Donnell Michael P. , Grunenkovaite Laura , Sengupta Piali 
Published: May 2024

ABSTRACTSensory neurons contain morphologically diverse primary cilia that are built by intraflagellar transport (IFT) and house sensory signaling molecules. Since both ciliary structural and signaling proteins are trafficked via IFT, it has been challenging to decouple the contributions of IFT and cilia structure to neuronal responses. By acutely inhibiting IFT without altering cilia structure andvice versa, here we describe the differential roles of ciliary trafficking and sensory ending morphology in shaping chemosensory responses inC. elegans.We show that a minimum cilium length but not continuous IFT is necessary for a subset of responses in the ASH nociceptive neurons. In contrast, neither cilia nor continuous IFT are necessary for odorant responses in the AWA olfactory neurons. Instead, continuous IFT differentially modulates response dynamics in AWA. Upon acute inhibition of IFT, cilia-destined odorant receptors are shunted to ectopic branches emanating from the cilia base. Spatial segregation of receptors in these branches from a cilia-restricted regulatory kinase results in odorant desensitization defects, highlighting the importance of precise organization of signaling molecules at sensory endings in regulating response dynamics. We also find that adaptation of AWA responses upon repeated exposure to an odorant is mediated by IFT-driven removal of its cognate receptor, whereas adaptation to a second odorant is regulated via IFT-independent mechanisms. Our results reveal unexpected complexity in the contribution of IFT and cilia organization to the regulation of responses even within a single chemosensory neuron type, and establish a critical role for these processes in the precise modulation of olfactory behaviors.
Vascular development of fetal and postnatal neocortex of the pig, the European wild boarSus scrofa
Authors: Sobierajski Eric , Czubay Katrin , Beemelmans Christa , Beemelmans Christoph , Meschkat Martin , Uhlenkamp Dennis , Meyer Gundela , Wahle Petra 
Published: May 2024

AbstractThe development of the brain’s vascular system is a predominantly prenatal process in mammalian species and required for neurogenesis and further brain development. Our recent work on fetal pig has revealed that many neurodevelopmental processes start well before birth and proceed rapidly reaching near-mature status already around birth. Here, we analyzed the development of neocortical vasculature from embryonic day (E) 45 onwards (gestation in pig lasts 114 days) using qualitative and quantitative image analyses and protein blots. In all cortical layers, vessel volume from total brain volume at E100 resembled that of a postnatal day (P) 30 piglet. Endothelial cells expressed the tight junction protein claudin-5 from E45 onwards. GFAP+ and AQP4+ astrocytes, PDGFRβ+ pericytes and α-SMA+ smooth muscle cells are detectable near vessels at E60 suggesting an early assembly of blood-brain barrier components. The vascular system in the visual cortex is advanced before birth with an almost mature pattern at E100. Findings were confirmed by blots which showed a steady increase of expression of tight junction and angiogenesis-related proteins (claudin-5, occludin, VE-cadherin, PECAM-1/CD31) from E65 onwards until P90. The expression profile was similar in visual and somatosensory cortex. Together, we report a rapid maturation of the vascular system in pig cortex. Regarding activity-dependent aspects, the data suggest that angiogenesis might be influenced by spontaneous rather than sensory-evoked activity.Author contributionConceptualization and methodology: ES and PW; investigation and analysis: ES, KC; provided resources: CB, CB, MM, DU; visualization: ES, MM, DU; writing—original draft: ES, PW; writing—review and editing: ES, GM, PW; supervision and project administration: PW. All authors approved the manuscript.Summary statementVascular impairment is associated with neurodegenerative disorders. As a groundwork for future studies, we quantitatively analyzed development of cortical vasculature in the emerging translational model, the pig.ETHICAL APPROVALAll applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures were in accordance with the ethical standards or practice of the institution at which the studies were conducted.
Making aid work: institutional thresholds and FDI
Authors: Wang Dongni , Fillat-Castejón Carmen 
Published: May 2024

Purpose
The purpose of this paper is to analyse the institutional threshold effects of foreign aid on foreign direct investment (FDI).

Design/methodology/approach
This paper develops a theoretical model from an extended Solow model that introduces the conductive effect of institutions in an aid recipient country towards the capacity of attracting FDI. This study evidences threshold effects with the most recent panel threshold models that consider endogeneity issues. The data on economic institutions and foreign aid are decomposed into disaggregated level to reveal the detailed threshold pattern. Several sample subsets are used for a heterogeneity analysis.

Findings
Conducting empirical research on a sample of 62 countries during the period 2003–2016, this study finds robust evidence of the existence of an institutional threshold in the aid–FDI nexus which a country must attain to reap the full attraction of FDI by foreign aid providing financial resources. Furthermore, foreign aid tends to promote FDI in institutions characterized by a right-sized government, a strengthened legal system and an appropriate regulatory environment. On the other hand, aid may crowd out FDI. The results are robust to regional combinations and a subset of low and lower-middle-income countries. In addition, this study finds that aid targeted at social infrastructure and services has a positive effect regardless of institutional threshold.

Originality/value
This paper contributes to the literature by introducing a non-linear and discontinuous effect of aid on FDI, i.e. a threshold effect, highlighting the relevance of legal systems and regulations and the possibility of a crowding-out effect on FDI for specific institutional regimes. The thresholds provide a guide for donor countries to ensure aid effectiveness at the risk of being counterproductive and for recipient countries to better assess the institutional dimensions that need to be improved.
How many friends at work are too many? The nonlinear association between the number of friends, social support and mental well-being
Authors: Telecan Maria Ioana , Curseu Petru Lucian , Rus Claudia Lenuta 
Published: May 2024

PurposeWe grounded this study in the Too-Much-of-a-Good-Thing (TMGT) meta-theoretical framework to disentangle the costs and benefits associated with workplace friendship in a military setting.Design/methodology/approachWe collected data cross-sectionally through self-reports from 287 employees from the Romanian Air Force.FindingsThe number of friends had an inverted U-shaped association with perceived social support. Our results show that as the number of friends increases from 9 to 10, so does the social support. However, as the number of friends further increases above 10, social support tends to decrease rather than increase. Furthermore, we found that social support and all dimensions of mental well-being (emotional, social and psychological well-being) were positively associated. Moreover, social support mediated the relationship between the number of friends and the three dimensions of mental well-being.Research limitations/implicationsOur findings can help human resources policies in military organizations foster an organizational climate that cultivates friendship ties between employees, which is crucial for their social support and overall mental well-being.Originality/valueThis work provides additional information about the specific mechanisms through which the effects of workplace friendships on mental well-being occur.
Reduced interest option pricing for green bonds
Authors: Zheng Chengli , Jin Jiayu , Han Liyan 
Published: May 2024

PurposeThis paper originally proposed the fuzzy option pricing method for green bonds. Based on the requirements of arbitrage equilibrium, this paper draws on Merton's corporate bond option pricing model.Design/methodology/approachDescribing the asset value behavior of green bond issuing enterprises through diffusion-jump processes to reflect the uncertainty brought by carbon emission reduction policies and technologies, using approximation methods to get the analytical pricing formula and then, using a fuzzification technique of Choquet expectation under λ-additive fuzzy measures after considering fuzzy factors, the paper provides fuzzy intervals for the parity coupon rates of green bonds with different subjective levels for investors.FindingsThe paper proposes and argues the classical and fuzzy option pricing methods in turn for both corporate ordinary bonds and green bonds, considering carbon risk or climate risk. It implements the scenario analysis varying with industry emission standards and discusses the sensitiveness of the related key parameters of the option.Practical implicationsThe fuzzy option pricing for the green bonds provides the scope of the variable equilibrium values, operational theoretical supports and some policy implications of carbon reduction and promoting green funding.Originality/valueThe logic of introducing the fuzziness of the option pricing for the green bonds lies with considering the existence of fuzzy information about the project supported by the green bond and the subjectivity of investors and it also responds to changes in technological uncertainty and policy uncertainty in the process of “carbon peaking and carbon neutrality.”
Impact of construction workers informal safety communication (CWISC) on safety performance on construction sites
Authors: Acheampong Alex , Adjei Elvis Konadu , Adade-Boateng Anita , Acheamfour Victor Karikari , Afful Aba Essanowa , Boateng Evans 
Published: May 2024

PurposeAn understanding of the impact of construction workers informal safety communication (CWISC), a form of parallel safety communication between workers, on safety performance among construction workers is crucial in order to develop effective strategies for improving safety performance in the construction industry. However, research remains scant on the impact of CWISC on safety performance. This study empirically aims to test the relationship between these important constructs.Design/methodology/approachStatistical analysis was used to examine the relationship in a hypothetical model with two latent variables; the exogenous variables represented by two groups of informal safety communication: friends and crew members and the endogenous variables represented by two groups of Safety performance metrics: safety compliance and safety participation, was tested.FindingsThe emergent findings revealed that there is a significant relationship between informal safety communication among crew members and safety compliance, and also between informal safety communication among friends on construction sites and safety participation. These findings emphasize the importance of fostering effective safety communication and collaboration within construction crews, as well as recognizing the influence friendships on safety performance. Stakeholders can leverage on these findings to implement policies to improve safety performance.Originality/valueThe study presents insightful practical knowledge on how CWISC impacts safety performance on construction sites. Practical recommendations for organizations are also proposed, e.g., development of team-building activities, platforms for sharing safety-related information and experiences, mentorship programs and initiatives that encourage social interaction among workers.
Cloud service models, business continuity and disaster recovery plans, and responsibilities
Authors: Stamenkov Gjoko 
Published: May 2024

Purpose
The purpose of this article is to identify the role of cloud computing services in business continuity and disaster recovery plans and delineate responsibilities for their execution. In recent times, there has been a huge upsurge in the usage of cloud service models such as infrastructure-as-a-service, platform-as-a-service, software-as-a-service and disaster recovery-as-a-service. However, in case of an emergency event or during contract negotiations, a question might arise as to who should be accountable and responsible for the content and execution of recovery plans. The main stakeholders in this scenario are cloud service providers and cloud consumers.

Design/methodology/approach
After a review of academic articles, standards, guidelines and vendor documentation, a proposal for assigning accountability and responsibility for business continuity and disaster recovery plans is presented, based on the RACI (responsible, accountable, consulted and informed) matrix. In this regard, a critical information infrastructure protection plan, a disaster recovery plan, an information systems contingency plan and a business continuity plan have been elaborated on in the article.

Findings
RACI matrices are presented for three general cloud service models and for three DRaaS models (managed, assisted and self-service). Accountability and responsibilities depend on the deployed cloud service model and the roles of cloud service providers and cloud consumers.

Originality/value
The proposed model for accountability and responsibility assignment provides a guideline for the allocation of responsibilities to roles not only during recovery but also during contract negotiations between cloud service providers and cloud consumers. By delving into business continuity and disaster recovery processes and activities, similar yet nuanced RACI matrices should be developed, as presented in this paper. They need to be customised for the specific context.
What makes restorative justice equitable? “It’s a practice, not a program.”
Authors: Lustick Hilary , Hakouz Abeer , Ward-Seidel Allison , Gaias Larissa 
Published: May 2024

PurposeThis study facilitated restorative coordinators in co-constructing and proposing solutions to common problems in RJ implementation.Design/methodology/approachThis study used grounded theory to examine barriers to equitable restorative justice (RJ) implementation in the US. Drawing on interviews and focus groups with restorative coordinators, we used a combination of inductive and deductive coding consistent with the grounded theory approach.FindingsCoordinators distinguished between RJ as a top-down, isolated “program” versus RJ as a collaborative “practice” among all stakeholders. Only the latter was equitable, in their view, and required a consistent principal commitment to building and maintaining an inclusive school culture. Participants recommended that teacher and principal preparation provide opportunities to cultivate critical consciousness and participate in RJ practices.Originality/valueExisting research on discipline reform tends to focus on outcomes, such as suspension rates. Instead, participants focused on the reform process, viewing equitable RJ as an ongoing “practice” to improve school culture. Our findings also open new discussions about leadership preparation content and pedagogy: participants called for preparation programs to cultivate critical consciousness and facility with RJ. Lastly, the study’s recruitment and focus group design raise important considerations for future RJ research.
Audit firm tenure and corporate tax avoidance: evidence spanning COVID-19 pandemic
Authors: Kamarudin Khairul Anuar , Wan Ismail Wan Adibah , Harymawan Iman , Mohamad Ariff Akmalia 
Published: May 2024

Purpose
This study aims to examine the effect of audit firm tenure (AFT) on corporate tax avoidance (CTA) and the moderating effect of the COVID-19 pandemic.

Design/methodology/approach
The sample comprises 41,074 firm-year observations from 32 countries from 2015 to 2020, for which data are collected from various sources: financial data from the Refinitiv database, country corporate tax rates from the Tax Foundation, and other country-level data from the World Bank database. The authors use the book tax difference to measure CTA and multiple proxies for AFT.

Findings
This study finds that a longer AFT is associated with higher CTA, confirming the notion that long AFT impairs auditor independence. The findings remain robust when considering various AFT proxies, incorporating Hofstede’s cultural factors, using weighted least-squares estimation and addressing endogeneity through propensity score matching. This study also finds a non-linear relationship between extended client and auditor relationships and CTA, supporting the mandatory audit firm rotation regulation and increasing investors’ caution regarding the consequences of extended client–auditor relationships on firm behaviour.

Research limitations/implications
This study offers new evidence on the effect of the COVID-19 pandemic on the link between AFT and CTA and documents a non-linear relationship between AFT, which has not been addressed in prior studies.

Practical implications
The findings of this study have several significant practical implications. First, governments and policymakers gain insights into the consequences of extended auditor–client relationships, hence calling for a review of auditing and taxation regulations. Second, the findings provide important insights into the issue of auditor independence, especially during long engagements and crises such as COVID-19. Finally, investors and tax authorities should be more cautious about the risks of aggressive tax avoidance during crisis periods.

Originality/value
To the best of the authors’ knowledge, this is the first study to use a global data set to investigate the effect of AFT on CTA during the COVID-19 pandemic.