bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quelles pratiques les PME peuvent-elles utiliser pour favoriser l'intrapreneuriat ?
Authors: Carrier Camille , Gélinas Sylvie 
Published: January 2012

Résumé Dans un environnement d’affaires marqué par la concurrence, l’innovation est devenue un élément de survie pour la PME. Pour ce faire, le dirigeant d’une PME a plus que jamais besoin de favoriser l’intrapreneuriat, qui consiste dans la mise en œuvre d’innovations par un employé ou un groupe d’employés. Mais encore doit-il savoir comment s’y prendre. Cet article propose cinq approches à cet égard : miser sur l’initiative des employés, rechercher activement des intrapreneurs, mandater une équipe pour innover, inviter tous les employés à proposer des améliorations ou des innovations et aider les employés à créer leur propre entreprise. Il établit également les conditions essentielles pour assurer le succès de ces stratégies : l’ouverture aux nouvelles idées, une culture favorable à l’innovation, la capacité de bien exploiter la proximité avec les employés et la nécessité d’offrir des récompenses signifiantes à l’intrapreneur.
Pancreatic Metastasis from Renal Cell Carcinoma
Authors: D'ambra Marielda , Ricci Claudio , Casadei Riccardo , Minni Francesco 
Published: January 2012

Background Pancreatic metastases from renal cell carcinoma are uncommon. Methods Retrospective study of 8 patients with a diagnosis of pancreatic metastasis from renal cell carcinoma observed in our Institute. Results Patients were 6 (75%) males and 2 (25%) females. Mean age was 65.3 years. In 5 patients (57.1%), symptoms were present. The median interval of onset from nephrectomy was 10 years. No cases of synchronous pancreatic metastases were observed. Surgical resection was performed in 7 (87.5%) patients. At pathological examination, solitary metastases were identified in 5 patients (71.4%). No post-operative mortality was observed; the morbidity rate was 42.8%. In the group of patients who underwent pancreatic resection, median overall survival was 43.0 months (range 12.9–74.5), median disease-free survival was 23.6 months (range 9.9–74.5). Conclusions Pancreatic metastasis from renal cell carcinoma typically occurs after a long period from the initial nephrectomy, and seems to be related to a good prognosis.
Immunometabolism unveiled: Pioneering breakthroughs in cancer therapeutics
Authors: Eldering Eric , Ricci Jean‐Ehrland 
Published: June 2024

The field of immunometabolism cannot be considered ‘emerging’ anymore; it is at the moment one of the most active and rapidly evolving areas of biomedical research. Its hottest zone is cancer immunometabolism. This is partly due to the clinical application of immunotherapy, with either antibodies (checkpoint blockade) or cellular therapies (e.g., CAR‐T cells). In addition, the proliferating tumor cells create a nutrient‐deprived microenvironment that impairs the metabolic fitness and functionality of infiltrating immune cells such as T cells, NK cells, and macrophages. The key concepts are bidirectional metabolic signaling, plus the conviction that a better understanding of these processes will improve current immunotherapies, and foster new tools and targets for treatment. This collection of reviews will address various exciting aspects from junior and established scientists in the field.
An Octopus‐Inspired Stimulus‐Responsive Structural Color Hydrogel for Uterus Cervical Canal Stent
Authors: Zhang Lihao , Ren Lehao , Chen Yufei , Cao Yue , Li Sunlong , Lu Weipeng , Jia Yaoyuan , Li Yachun , Liu Cihui , Li Chen , Dong Qian 
Published: June 2024

AbstractSoft‐bodied aquatic organisms have exhibited remarkable capabilities in navigating and moving within liquid environments serving as a profound inspiration for the development of bionic robots with intricate movements. Traditional rigid components are being replaced by stimulus‐responsive soft materials such as hydrogels and shape memory polymers, leading to the creation of dynamically responsive soft robots. In this study, the development of a bionic robot inspired by the shape of an octopus and the adsorptive properties of its tentacles, specifically tailored for targeted stimulation and pH sensing in the cervix, are presented. This approach involves the design of a soft, water‐based Janus adhesive hydrogel patch that adheres to specific parts of the cervix and responds to pH changes through external stimuli. The hydrogel patch incorporates inverse opal microstructures mimicking the legs of an octopus, to facilitate efficient and stable locomotion, unidirectional transport of biofluids, and pH‐responsive behavior. This miniature bionic robot showcases controlled adhesion and precise unidirectional fluid transport highlighting its potential for targeted stimulus response and pH sensing in the uterine cervical tract. This breakthrough opens new avenues for medical applications within the expanding field of soft‐bodied robotics.
High‐Performance NIR‐II Fluorescent Type I/II Photosensitizer Enabling Augmented Mild Photothermal Therapy of Tumors by Disrupting Heat Shock Proteins
Authors: Jiang Quanheng , Li Jingyu , Du Zhong , Li Mengyuan , Chen Liying , Zhang Xunwen , Tang Xialian , Shen Yaowei , Ma Dalong , Li Wen , Li Lin , Alifu Nuernisha , Hu Qinglian , Liu Jie 
Published: June 2024

AbstractNIR‐II fluorescent photosensitizers as phototheranostic agents hold considerable promise in the application of mild photothermal therapy (MPTT) for tumors, as the reactive oxygen species generated during photodynamic therapy can effectively disrupt heat shock proteins. Nevertheless, the exclusive utilization of these photosensitizers to significantly augment the MPTT efficacy has rarely been substantiated, primarily due to their insufficient photodynamic performance. Herein, the utilization of high‐performance NIR‐II fluorescent type I/II photosensitizer (AS21:4) is presented as a simple but effective nanoplatform derived from molecule AS2 to enhance the MPTT efficacy of tumors without any additional therapeutic components. By taking advantage of heavy atom effect, AS21:4 as a type I/II photosensitizer demonstrates superior efficacy in producing 1O2 (1O2 quantum yield = 12.4%) and O2•− among currently available NIR‐II fluorescent photosensitizers with absorption exceeding 800 nm. In vitro and in vivo findings demonstrate that the 1O2 and O2•− generated from AS21:4 induce a substantial reduction in the expression of HSP90, thereby improving the MPTT efficacy. The remarkable phototheranostic performance, substantial tumor accumulation, and prolonged tumor retention of AS21:4, establish it as a simple but superior phototheranostic agent for NIR‐II fluorescence imaging‐guided MPTT of tumors.
Challenges and Opportunities for Single‐Atom Electrocatalysts: From Lab‐Scale Research to Potential Industry‐Level Applications
Authors: Jia Chen , Sun Qian , Liu Ruirui , Mao Guangzhao , Maschmeyer Thomas , Gooding J. Justin , Zhang Tao , Dai Liming , Zhao Chuan 
Published: June 2024

AbstractSingle‐atom electrocatalysts (SACs) are a class of promising materials for driving electrochemical energy conversion reactions due to their intrinsic advantages, including maximum metal utilization, well‐defined active structures, and strong interface effects. However, SACs have not reached full commercialization for broad industrial applications. This review summarizes recent research achievements in the design of SACs for crucial electrocatalytic reactions on their active sites, coordination, and substrates, as well as the synthesis methods. The key challenges facing SACs in activity, selectivity, stability, and scalability, are highlighted. Furthermore, it is pointed out the new strategies to address these challenges including increasing intrinsic activity of metal sites, enhancing the utilization of metal sites, improving the stability, optimizing the local environment, developing new fabrication techniques, leveraging insights from theoretical studies, and expanding potential applications. Finally, the views are offered on the future direction of single‐atom electrocatalysis toward commercialization.
Integrated Single‐Cell RNA‐seq and ATAC‐seq Reveals Heterogeneous Differentiation of CD4+ Naive T Cell Subsets is Associated with Response to Antidepressant Treatment in Major Depressive Disorder
Authors: Sun Zuoli , Zhang Bowen , Zhou Jingjing , Luo Yanting , Zhu Xuequan , Wang Yaping , He Yi , Zheng Peng , Zhang Ling , Yang Jian , Wang Gang 
Published: June 2024

AbstractThe mechanism involved in major depressive disorder (MDD) is well‐studied but the mechanistic origin of the heterogeneous antidepressant effect remains largely unknown. Single‐cell RNA‐sequencing (scRNA‐seq) and assay for transposase‐accessible chromatin using sequencing (ATAC‐seq) on peripheral blood mononuclear cells from 8 healthy individuals and 8 MDD patients before or after 12 weeks of antidepressant treatment is performed. scRNA‐seq analysis reveals a lower proportion of naive T cells, particularly CD4+ naive T cells, in MDD patients compared to controls, and in nonresponders versus responders at the baseline. Flow cytometry data analysis of an independent cohort of 35 patients and 40 healthy individuals confirms the findings. Enrichment analysis of differentially expressed genes indicated obvious immune activation in responders. A specific activated CD4+ naive T population in responders characterized by enhanced mitogen‐activated protein kinases (MAPK) pathway is identified. E‐twenty six (ETS) is proposed as an upstream regulator of the MAPK pathway and heterogeneous differentiation in activated CD4+ naive T population is associated with the response to antidepressant treatment in MDD patients. A distinct immune feature manifested by CD4+ naive T cells during antidepressant treatment in MDD is identified. Collectively, this proposes the molecular mechanism that underlies the heterogeneous antidepressant outcomes for MDD.
Maternal Obesity Induces the Meiotic Defects and Epigenetic Alterations During Fetal Oocyte Development
Authors: Tang Shoubin , Wu Huihua , Chen Qiuzhen , Tang Tao , Li Jiashuo , An Huiqing , Zhu Shuai , Han Longsen , Sun Hongzheng , Ge Juan , Qian Xu , Wang Xi , Wang Qiang 
Published: June 2024

AbstractIt has been widely reported that obesity adversely impacts reproductive performance of females. However, the effects of maternal obesity on fetal germ cells remain poorly understood. In the present study, by employing a high‐fat diet (HFD)‐based mouse model, it is discovered that maternal obesity disrupts the chromosomal synapsis and homologous recombination during fetal oogenesis. Moreover, transcriptomic profiling reveales the potential molecular network controlling this process. Of note, the global hypermethylation of genomic DNA in fetal oocytes from obese mouse is detected. Importantly, time‐restricted feeding (TRF) of obese mice not only ameliorate the meiotic defects, but also partly restore the epigenetic remodeling in fetal oocytes. In sum, the evidence are provided showing the deficit fetal oogenesis in obese mother, implicating a mechanism underlying the intergenerational effects of environmental insults. TRF may represent a potentially effective approach for mitigating fertility issues in obese patients.
Sonosynthetic Cyanobacteria Oxygenation for Self‐Enhanced Tumor‐Specific Treatment
Authors: Yang Zhenyu , Shen Xiu , Jin Junyi , Jiang Xiaoyan , Pan Wenqi , Wu Chenyao , Yu Dehong , Li Ping , Feng Wei , Chen Yu 
Published: June 2024

AbstractPhotosynthesis, essential for life on earth, sustains diverse processes by providing nutrition in plants and microorganisms. Especially, photosynthesis is increasingly applied in disease treatments, but its efficacy is substantially limited by the well‐known low penetration depth of external light. Here, ultrasound‐mediated photosynthesis is reported for enhanced sonodynamic tumor therapy using organic sonoafterglow (ultrasound‐induced afterglow) nanoparticles combined with cyanobacteria, demonstrating the proof‐of‐concept sonosynthesis (sonoafterglow‐induced photosynthesis) in cancer therapy. Chlorin e6, a typical small‐molecule chlorine, is formulated into nanoparticles to stimulate cyanobacteria for sonosynthesis, which serves three roles, i.e., overcoming the tissue‐penetration limitations of external light sources, reducing hypoxia, and acting as a sonosensitizer for in vivo tumor suppression. Furthermore, sonosynthetic oxygenation suppresses the expression of hypoxia‐inducible factor 1α, leading to reduced stability of downstream SLC7A11 mRNA, which results in glutathione depletion and inactivation of glutathione peroxidase 4, thereby inducing ferroptosis of cancer cells. This study not only broadens the scope of microbial nanomedicine but also offers a distinct direction for sonosynthesis.
Leveraging Senescent Cancer Cell Membrane to Potentiate Cancer Immunotherapy Through Biomimetic Nanovaccine
Authors: Yang Chao , Chen Yinglu , Liu Jie , Zhang Wensheng , He Yan , Chen Fangman , Xie Xiaochun , Tang Jie , Guan Shan , Shao Dan , Wang Zheng , Wang Liang 
Published: June 2024

AbstractSenescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies. However, the efficacy of live senescent cancer cell‐based vaccination is limited by interference from immunosuppressive senescence‐associated secretory phenotype and pro‐tumorigenic capacity of senescent cells. Here, a senescent cancer cell‐based nanovaccine with strong immunogenicity and favorable potential for immunotherapy is reported. The biomimetic nanovaccine integrating a senescent cancer cell membrane‐coated nanoadjuvant outperforms living senescent cancer cells in enhancing dendritic cells (DCs) internalization, improving lymph node targeting, and enhancing immune responses. In contrast to nanovaccines generated from immunogenic cell death‐induced tumor cells, senescent nanovaccines facilitate DC maturation, eliciting superior antitumor protection and improving therapeutic outcomes in melanoma‐challenged mice with fewer side effects when combined with αPD‐1. The study suggests a versatile biomanufacturing approach to maximize immunogenic potential and minimize adverse effects of senescent cancer cell‐based vaccination and advances the design of biomimetic nanovaccines for cancer immunotherapy.
Harnessing Disparities in Magnetic Microswarms: From Construction to Collaborative Tasks
Authors: Cao Chuan , Mou Fangzhi , Yang Manyi , Zhang Shuming , Zhang Di , Li Luolin , Lan Tong , Xiao Dunyi , Luo Wei , Ma Huiru , Guan Jianguo 
Published: June 2024

AbstractIndividual differences in size, experience, and task specialization in natural swarms often result in heterogeneity and hierarchy, facilitating efficient and coordinated task accomplishment. Drawing inspiration from this phenomenon, a general strategy is proposed for organizing magnetic micro/nanorobots (MNRs) with apparent differences in size, shape, and properties into cohesive microswarms with tunable heterogeneity, controlled spatial hierarchy, and collaborative tasking capability. In this strategy, disparate magnetic MNRs can be manipulated to show reversible transitions between synchronization and desynchronization by elaborately regulating parameter sets of the rotating magnetic field. Utilizing these transitions, alongside local robust hydrodynamic interactions, diverse heterospecific pairings of disparate magnetic MNRs can be organized into heterogeneous microswarms, and their spatial organization can be dynamically adjusted from egalitarian to leader‐follower‐like hierarchies on the fly, both in open space and complex microchannels. Furthermore, when specializing the disparate MNRs with distinct functions (“division of labor”) such as sensing and drug carrying, they can execute precise drug delivery targeting unknown sites in a collaborative sensing‐navigating‐cargo dropping sequence, demonstrating significant potential for precise tumor treatment. These findings highlight the critical roles of attribute differences and hierarchical organization in designing efficient swarming micro/nanorobots for biomedical applications.
Malleable, Ultrastrong Antibacterial Thermosets Enabled by Guanidine Urea Structure
Authors: Yu Zhen , Li Qiong , Liu Yanlin , Tian Shu , Chen Wanding , Han Yingying , Tang Zhaobin , Zhang Junping 
Published: June 2024

AbstractDynamic covalent polymers (DCPs) that strike a balance between high performance and rapid reconfiguration have been a challenging task. For this purpose, a solution is proposed in the form of a new dynamic covalent supramolecular motif—guanidine urea structure (GUAs). GUAs contain complex and diverse chemical structures as well as unique bonding characteristics, allowing guanidine urea supramolecular polymers to demonstrate advanced physical properties. Noncovalent interaction aggregates (NIAs) have been confirmed to form in GUA‐DCPs through multistage H‐bonding and π‐π stacking, resulting in an extremely high Young's modulus of 14 GPa, suggesting remarkable mechanical strength. Additionally, guanamine urea linkages in GUAs, a new type of dynamic covalent bond, provide resins with excellent malleability and reprocessability. Guanamine urea metathesis is validated using small molecule model compounds, and the temperature dependent infrared and rheological behavior of GUA‐DCPs following the dissociative exchange mechanism. Moreover, the inherent photodynamic antibacterial properties are extensively verified by antibacterial experiments. Even after undergoing three reprocessing cycles, the antibacterial rate of GUA‐DCPs remains above 99% after 24 h, highlighting their long‐lasting antibacterial effectiveness. GUA‐DCPs with dynamic nature, tuneable composition, and unique combination of properties make them promising candidates for various technological advancements.
Zeolite Membrane‐Based Low‐Temperature Dehydrogenation of a Liquid Organic Hydrogen Carrier: A Key Step in the Development of a Hydrogen Economy
Authors: Kim Sejin , Lee Seungmi , Sung Suhyeon , Gu Sangseo , Kim Jinseong , Lee Gihoon , Park Jaesung , Yip Alex C. K. , Choi Jungkyu 
Published: June 2024

AbstractMethylcyclohexane (MCH) dehydrogenation is an equilibrium‐limited reaction that requires high temperatures (>300 °C) for complete conversion. However, high‐temperature operation can degrade catalytic activity and produce unwanted side products. Thus, a hybrid zeolite membrane (Z) is prepared on the inner surface of a tubular support and used it as a wall in a membrane reactor (MR) configuration. Pt/C catalysts is packed diluted with quartz sand inside the Z‐coated tube and applied the MR for MCH dehydrogenation at low temperatures (190–250 °C). Z showed a remarkable H2‐permselectivity in the presence of both toluene and MCH, yielding separation factors over 350. The Z‐based MR achieved higher MCH conversion (75.3% ± 0.8% at 220 °C) than the conventional packed‐bed reactor (56.4% ± 0.3%) and the equilibrium state (53.2%), owing to the selective removal of H2 through Z. In summary, the hybrid zeolite MR enhances MCH dehydrogenation at low temperatures by overcoming thermodynamic limitations and improves the catalytic performance and product selectivity of the reaction.
How to measure quality of surgery as a component of multimodality treatment of gastric cancer
Authors: Polkowski Wojciech P. , Gęca Katarzyna , Skórzewska Magdalena 
Published: June 2024

AbstractGastric cancer (GC) is one of the most frequent reasons for cancer‐related death worldwide. The multimodal therapeutic strategies are now pragmatically tailored to each patient, especially in advanced GC. A radical but safe gastrectomy remains the cornerstone of the GC treatment. Moreover, the quality‐of‐life (QoL) outcome measures are now routinely utilized in order to select optimal type of gastrectomy, as well as reconstruction method. Postoperative complications are frequent, and effective diagnosis and treatment of complications is crucial to lower the mortality rates. The postoperative complications prolong hospital stay and may result in poor QoL, thus eliminating the completion of perioperative adjuvant therapy. Therefore, avoiding morbidity is not only relevant for the immediate postoperative course, but can also affect long‐term oncological outcome. Measuring outcome enables surgeons to: monitor their own results; compare quality of treatment between centres; facilitate improvement both for surgery alone and combined treatment; select optimal procedure for an individual patient. Textbook oncological outcome is a composite quality measure representing the ideal hospitalization for gastrectomy, as well as stage‐appropriate (perioperative) adjuvant chemotherapy. Standardized system for recording complications and adherence to multimodality treatment guidelines are crucial for achieving the ultimate goal of surgical quality‐improvement that can benefit patients QoL and long‐term outcomes after fast and uneventful hospitalization for gastrectomy.
Unveiling the exceptional evolution of solute aggregates: From micro to trace, solution to interface
Authors: Wang Weili , Ma Hao , Huang Qiuting , Luo Siheng , Ren Bin , Tian Zhongqun , Liu Guokun 
Published: June 2024

AbstractExistential state of solutes substantially affects the efficiency and direction of various chemical and biological processes, about which current consensus is still limited at macro and micro levels. At the trace level, solutes assume a pivotal role across a spectrum of critical fields. However, their existential states, especially at interfaces, remain largely elusive. Herein, an exceptional evolution of solute molecules is unveiled from micro to trace, solution to interface, with the aid of surface‐enhanced Raman spectroscopy, extinction, DLS and theoretical simulations. Given predominant existence of monomers within the solution, these aggregates dominate the interfacial behavior of solute molecules. Moreover, a universal, aggregate‐controlled mechanism is demonstrated that aggregates triggered by cosolvent, which can dramatically promote efficiency of catalytic reactions. The results provide novel insights into the interaction mechanisms between reactants and catalysts, potentially offering fresh perspectives for the manipulation of multiphase catalysis and related biological processes.
Investigation of Acoustic Attenuation and Resonances in Lithium‐Ion Batteries Using Ultrasound Spectroscopy
Authors: Feiler Simon , Gold Lukas , Hartmann Sarah , Giffin Guinevere A. 
Published: June 2024

AbstractUltrasound spectroscopy up to 6 MHz is carried out on a 12 Ah Lithium‐ion battery pouch‐cell. The analysis revealed that the attenuation behavior can be effectively described as having an absorption component and a resonance component. It was demonstrated that the absorption can be modeled as a second order polynomial. Two distinct resonances were identified at 2.2 MHz and 4.4 MHz. The first of these resonances shows a significant almost linear reduction in magnitude with increasing state of charge. By smartly choosing the ultrasound interrogation frequency to coincide with this resonance, an almost linear increase by a factor of more than five was measured in the signal amplitude between between state of charge levels of 0 and 100. This could provide the basis for a robust and straightforward state of charge determination method.