bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trends in Preventive Asthma Medication Use Among Children and Adolescents, 1988–2008
Authors: Kit Brian K. , Simon Alan E. , Ogden Cynthia L. , Akinbami Lara J. 
Published: December 2011

Objectives:To examine trends in preventive asthma medication (PAM) use among children with current asthma in the United States from 1988 to 2008.Methods:We performed a cross-sectional analysis of PAM use among 2499 children aged 1 to 19 years with current asthma using nationally representative data from the National Health and Nutrition Examination Survey (NHANES) during 3 time periods: 1988–1994, 1999–2002, and 2005–2008. PAMs included inhaled corticosteroids, leukotriene receptor antagonists, long-acting β-agonists, mast-cell stabilizers, and methylxanthines.Results:Among children with current asthma, there was an increase in the use of PAMs from 17.8% (SE: 3.3) in 1988–1994 to 34.9% (SE: 3.3) in 2005–2008 (P &lt; .001 for trend). Adjusting for age, gender, race/ethnicity, and health insurance status, the odds of PAM use were higher in 2005–2008 compared with 1988–1994 (adjusted odds ratio [aOR] = 2.6; 95% confidence interval [CI]: 1.5–4.5). A multivariate analysis, combining all 3 time periods, showed lower use of PAMs among non-Hispanic black (aOR = 0.5 [95% CI: 0.4–0.7]) and Mexican American (aOR = 0.6 [95% CI: 0.4–0.9]) children compared to non-Hispanic white children. PAM use was also lower in 12 to 19 year olds compared with 1 to 5 year olds and also in children who did not have health insurance compared with those who did.Conclusions:Between 1988 and 2008, the use of PAM increased among children with current asthma. Non-Hispanic black and Mexican American children, adolescents aged 12 to 19 years, and uninsured children with current asthma had lower use of PAM.
Impact of HER-2 Overexpression/Amplification on the Prognosis of Gastric Cancer Patients Undergoing Resection: A Single-Center Study of 1,036 Patients
Authors: Hsu Jun-Te , Chen Tse-Ching , Tseng Jeng-Hwei , Chiu Cheng-Tang , Liu Keng-Hao , Yeh Chun-Nan , Hwang Tsann-Long , Jan Yi-Yin , Yeh Ta-Sen 
Published: December 2011

Abstract

Background.
Opinions regarding the impact of human epidermal growth factor receptor (HER)-2 overexpression or HER-2 amplification on the prognosis of gastric cancer patients are mixed. The present study attempted to clarify this issue by investigating a large cohort of surgical patients.

Methods.
We investigated 1,036 gastric cancer patients undergoing curative-intent resection. Their surgical specimens were evaluated for HER-2 expression by immunohistochemistry (IHC), and those with HER-2 expression levels of 2+ were additionally subjected to fluorescence in situ hybridization (FISH). Data on demographic and clinicopathological features and relevant prognostic factors in these patients were analyzed.

Results.
HER-2 positivity was noted in 64 (6.1%) of 1,036 gastric cancer patients, including 46 patients whose HER-2 expression level was 3+ on IHC and 18 patients whose FISH results were positive. On univariate analysis, HER-2 positivity was more often associated with differentiated histology, intestinal type, and negative resection margins, whereas only differentiated histology was independently associated with HER-2 positivity in a logistic regression model. For stage I–IV gastric cancer, HER-2 was not a prognostic factor. In a subpopulation study, although HER-2 positivity emerged as a favorable prognostic factor for stage III–IV gastric cancer on univariate analysis, it failed to be an independent prognostic factor after multivariate adjustment.

Conclusions.
The prevalence of HER-2 positivity, determined using standardized assays and scoring criteria in a large cohort of gastric cancer patients after resection, was 6.1%. HER-2 positivity was phenotypically associated with differentiated histology. HER-2 is not an independent prognostic factor for gastric cancer.
A Randomized Clinical Trial to Evaluate and Compare Implants Placed in Augmented Versus Non‐Augmented Extraction Sockets: 3‐Year Results
Authors: Barone Antonio , Orlando Bruno , Cingano Luciano , Marconcini Simone , Derchi Giacomo , Covani Ugo 
Published: December 2011

Background: The alveolar ridge undergoes reabsorption and atrophy subsequent to tooth removal and thus exhibits a wide range of dimensional changes. Preservation of the alveolar crest after tooth extraction is essential to enhance the surgical site before implant fixture placement. The aim of this randomized clinical study is to investigate and compare the need for additional augmentation procedures at implant insertion, as well as the success rate and marginal bone loss for implants placed in the grafted sites versus those placed in naturally healed sites.Methods: Forty patients with ≥1 hopeless tooth were randomly allocated to: 1) a test group, receiving extraction and grafting corticocancellous porcine bone; and 2) a control group, receiving extraction without any graft. After 7 months of healing, implants were inserted in each of the sites. The implants were submerged and loaded after 4 months with metal–ceramic rehabilitation. The follow‐up included evaluation of implant diameter and length, the need for additional augmentation procedures at implant placement, implant failure, and marginal bone level changes. All patients were followed over a 3‐year period.Results: One implant failed in the control group at the second stage of surgery (6 months after placement); one implant failed in the test group after 2 years of loading. The cumulative implant success rate at the 3‐year follow‐up visit reached 95% for both groups. No statistically significant differences were detected for marginal bone changes between the two groups.Conclusions: It was concluded that implants placed into grafted extraction sockets exhibited a clinical performance similar to implants placed into non‐grafted sites in terms of implant survival and marginal bone loss. However, grafted sites allowed placement of larger implants and required less augmentation procedures at implant placement when compared to naturally healed sites.
Oral Mucosa Tissue Response to Titanium Cover Screws
Authors: Olmedo Daniel G. , Paparella María L. , Spielberg Martín , Brandizzi Daniel , Guglielmotti María B. , Cabrini Rómulo L. 
Published: December 2011

Background: Titanium is the most widely used metal in dental implantology. The release of particles from metal structures into the biologic milieu may be the result of electrochemical processes (corrosion) and/or mechanical disruption during insertion, abutment connection, or removal of failing implants. The aim of the present study is to evaluate tissue response of human oral mucosa adjacent to titanium cover screws.Methods: One hundred fifty‐three biopsies of the supra‐implant oral mucosa adjacent to the cover screw of submerged dental implants were analyzed. Histologic studies were performed to analyze epithelial and connective tissue as well as the presence of metal particles, which were identified using microchemical analysis. Langerhans cells, macrophages, and T lymphocytes were studied using immunohistochemical techniques. The surface of the cover screws was evaluated by scanning electron microscopy (SEM).Results: Forty‐one percent of mucosa biopsies exhibited metal particles in different layers of the section thickness. Particle number and size varied greatly among specimens. Immunohistochemical study confirmed the presence of macrophages and T lymphocytes associated with the metal particles. Microchemical analysis revealed the presence of titanium in the particles. On SEM analysis, the surface of the screws exhibited depressions and irregularities.Conclusions: The biologic effects seen in the mucosa in contact with the cover screws might be associated with the presence of titanium or other elements, such as aluminum or vanadium. The potential long‐term biologic effects of particles on soft tissues adjacent to metallic devices should be further investigated because these effects might affect the clinical outcome of the implant.
The Subgingival Microbiota of Papillon‐Lefèvre Syndrome
Authors: Albandar Jasim M. , Khattab Razan , Monem Fawza , Barbuto Sara M. , Paster Bruce J. 
Published: December 2011

Background: There is little information about the microbiologic profiles of periodontal lesions in Papillon‐Lefèvre syndrome (PLS) and the significance of bacteria in the pathogenesis of periodontitis in these patients. This comprehensive analysis of the subgingival microbiota in patients with PLS used 16S ribosomal RNA (rRNA) clonal analysis and the 16S rRNA‐based Human Oral Microbe Identification Microarray (HOMIM).Methods. Thirteen patients with PLS from seven unrelated families volunteered for this microbiologic study. Subgingival plaque was collected with sterile paper points from multiple sites with ≥5 mm probing depth, and whole genomic DNA was extracted. The 16S rRNA genes were amplified, cloned, and sequenced. The samples were then probed for ≈300 predominant oral bacterial species using the HOMIM.Results: The most commonly detected phylotypes in the clonal analysis were Gemella morbillorum, Gemella haemolysans, Granulicatella adiacens, Lachnospiraceae OT 100 (EI074), Parvimonas micra, Selenomonas noxia, and Veillonella parvula. As a group, streptococci were commonly detected in these individuals. In the HOMIM analysis, a total of 170 bacterial species/phylotypes were detected, with a range of 40 to 80 species per patient with PLS. Of these, 12 bacterial species were detected in medium to high levels in ≥50% of the individuals. The high‐frequency strains were clustered into eight groups: Aggregatibacter actinomycetemcomitans, Campylobacter spp., Capnocytophaga granulosa, G. morbillorum, P. micra, Porphyromonas endodontalis, Streptococcus spp., and Tannerella forsythia.Conclusions: The subgingival microbiota in PLS is diverse. Periodontal pathogens commonly associated with chronic and aggressive periodontitis and opportunistic pathogens may be associated with the development of severe periodontitis in patients with PLS.
Erysipelas in breast cancer patients after the radical mastectomy
Authors: Matijasevic Miodrag , Dekic Natasa , Kolarevic Daniela , Milosevic Snezana , Tomasevic Zorica , Jurisic Vladimir 
Published: December 2011

AbstractErysipelas is a bacterial cellulitis usually associated with Streptococcal infection. It may appear as a complication following mastectomy and radiotherapy for breast cancer. The study involved 17 cases of erysipelas of the upper limbs with a median age of 62 years. Here we described the clinical, therapeutic and evolutionary aspects of erysipelas. Our results indicated that the erysipelas appeared with an average of 9 years after mastectomy and was recurrent in three patients (17.64%). It is associated with obesity in 42% and arterial hypertension in 52.9% of patients with breast cancer after radical mastectomy. Breast cancer patients in advance stages of disease at presentation (T2+ T3) are significantly more subject to erysipelas in comparison to those patients with locoregional stage of disease at presentation (T1), Mann Whitney U-test, (p<0.05). All patients had complete response to antibiotics. The recurrence occurred in 2 patients (11.76%) who underwent radiotherapy with adjuvant tamoxifen and in one patient who underwent chemotherapy and radiotherapy combined. Based on these results it is possible to suggest that patients who received radiotherapy may have an additional risk factor for developing lymphedema and erysipelas
Les occupations mésolithiques à l'intérieur du Finistère. Bilan archéographique et méthodologique (2001-2003) / Mesolithic occupations in the hinterland of Finistère. An archaeographic and methodologie assessment (2001-2003)
Authors: Marchand Grégor 
Published: December 2011

Les prospections réalisées entre 1989 et 2003 sur le département du Finistère, d'abord sous la houlette de Pierre Gouletquer, puis de ses collaborateurs, ont permis de bâtir une base de données comportant 1318 entrées en avril 2004, qui sont autant de traces d'occupations préhistoriques. Entre 2001 et 2003, le programme « Le Mésolithique en Finistère : chronologie et stratigraphie » a permis de classer ce corpus suivant des critères typologiques, introduisant des attributions chronologiques dans un ensemble alors assez indéterminé. A l'issue de cette étude, 92 sites mésolithiques de plus de 30 pièces peuvent être inventoriés. L'étape suivante consistait à comprendre la nature stratigraphique de sites de surface, pour acquérir de nouvelles données concernant le fonctionnement des habitats, mais également pour apporter des éléments de réflexion quant à la conservation de ce « patrimoine diffus ». Après de nombreuses visites sur le terrain, une liste de sites permettant les fouilles a été établie, en tentant de faire varier les contextes topographiques.
Cinq sites ont finalement pu être sondés. Kerliézoc (Plouvien) reposait sur une pente faible orientée au nord ; Kerdunvel (Plourin-Ploudalmézeau) était en position de promontoire ; La Trinité-Goarem-Lann (Melgven) associait vallon sec, promontoire, pentes plus ou moins prononcées et vallée humide ; La Villeneuve (Locunolé) gisait sur une basse terrasse non-inondable au fond d'un canyon ; La Presqu'île (Brennilis) - pourtant le site le plus prometteur - s'avérait être entièrement déplacé par l'action d'un lac de barrage sur le flanc d'un ancien ruisseau. Aucun de ces sites n'a livré de niveau archéologique préservé, ni a fortiori de structures. Il appert que les limites actuelles des sites sont souvent des limites érosives. Les données recueillies lors des sondages ne sont cependant pas négligeables pour caractériser plus finement les techniques de taille et les principes des économies d'acquisition à l'extrême ouest de la France, que ce soit pour le Mésolithique moyen (Groupe de Bertheaume à La Trinité-Goarem-Lann et La Villeneuve) ou pour le Mésolithique final (Téviecien à Kerliézoc, Kerdunvel et La Presqu'île).
Une méthode de terrain est proposée, associant tamisage systématique de la totalité des strates et tranchées à la pelle mécanique. Elle permet de rendre compte de ces gisements si peu spectaculaires, mais qui témoignent à leur manière de cette période fondamentale pour l'histoire de l'humanité précédant immédiatement le basculement vers les économies de production. La prise en compte de ce « patrimoine diffus » impose de s'interroger sur ce que l'on préserve et sur ce que l'on fouille, dans une perspective non fixiste de notre mémoire collective.
Data Analysis and Data Mining: Current Issues in Biomedical Informatics
Authors: Diomidous M. , Sarkar I. N. , Takabayashi K. , Ziegler A. , McCray A. T. , Bellazzi R. 
Published: December 2011

SummaryBackground: Medicine and biomedical sciences have become data-intensive fields, which, at the same time, enable the application of data-driven approaches and require sophisticated data analysis and data mining methods. Biomedical informatics provides a proper interdisciplinary context to integrate data and knowledge when processing available information, with the aim of giving effective decision-making support in clinics and translational research.Objectives: To reflect on different perspectives related to the role of data analysis and data mining in biomedical informatics. Methods: On the occasion of the 50th year of Methods of Information in Medicine a symposium was organized, which reflected on opportunities, challenges and priorities of organizing, representing and analysing data, information and knowledge in biomedicine and health care. The contributions of experts with a variety of backgrounds in the area of biomedical data analysis have been collected as one outcome of this symposium, in order to provide a broad, though coherent, overview of some of the most interesting aspects of the field.Results: The paper presents sections on data accumulation and data-driven approaches in medical informatics, data and knowledge integration, statistical issues for the evaluation of data mining models, translational bioinformatics and bioinformatics aspects of genetic epidemiology.Conclusions: Biomedical informatics represents a natural framework to properly and effectively apply data analysis and data mining methods in a decision-making context. In the future, it will be necessary to preserve the inclusive nature of the field and to foster an increasing sharing of data and methods between researchers.
Total Condylar Unipolar Expandable Prosthesis for Proximal Tibia Malignant Bone Tumors in Early Childhood
Authors: Lozano-Calderón Santiago A. , Kenan Samuel 
Published: December 2011

Wide resection and reconstruction of tumors of the proximal tibia in the pediatric population are challenging procedures. The use of hinged, expandable prostheses may cause early closure of the distal femoral growth plate, which may increase the risk of limb discrepancy already present in this population.
Between 1991 and 2001, 2 girls and 1 boy, aged 6, 6, and 4 years, respectively, were diagnosed with osteosarcoma of the proximal tibia and treated with wide resection and reconstruction with a condylar unipolar expandable tibial prosthesis. A press-fitted technique was used for component insertion. All patients received neoadjuvant and adjuvant chemotherapy. Radiographic and functional follow-up took place at least once a year for a minimum of 4 years. Adequate pain control, limb-length equality, and acceptable function were obtained in all patients. One patient presented with significant range of motion reduction (0°– 30°) in the affected knee. Limb lengthening was performed as needed to maintain balanced limb length. All patients had a good Musculoskeletal Tumor Society category score. No complications occurred in terms of component loosening or infection. One patient died shortly after 4-year follow-up because of doxorubicin-induced leukemia.
Currently used hinged, expandable prostheses can jeopardize the unaffected distal femoral growth plate. This article describes a technique of reconstruction that spares the distal femoral growth plate. Adequate limb length can be expected with acceptable functional outcome. However, it is imperative to keep in perspective the expectations of the physician, the physician’s team, the patient, and the patient’s family.
Surgical Treatment for Permanent Dislocation of the Patella in Adults
Authors: Noda Mitsuaki , Saegusa Yasuhiro , Kashiwagi Naoya , Seto Yoichi 
Published: December 2011

Permanent dislocation of the patella in adults is a rare condition that presents with complete irreducible lateral dislocation of the patella, combined with secondary changes, such as valgus deformity and leg-length discrepancy. Because these secondary changes cannot heal spontaneously after skeletal maturation if left untreated, the patients frequently possess pathology not limited to the knee joint and extending to the whole lower extremity, such as malalignment or leg-length discrepancy, that can develop into osteoarthritis of the knee. However, to our knowledge, few surgeons advocate the significance of correcting the malalignment in treating adult patients.
We treated a 34-year-old woman with permanent dislocation of the patella in a 2-stage surgery, consisting of first-stage correction of valgus deformity and limb shortening using a Ilizarov external fixator and second-stage realignment of the dislocated patella over the trochlea. A follow-up examination conducted 3 years after the second operation revealed plantigrade gait with normal alignment of the lower extremity without limping and medial thrust. The patella was tracking centrally in the patellofemoral groove. Radiographs showed a neutral mechanical axis of the lower extremity, no evidence of patellar subluxation, and no deteriorating osteoarthritic changes at the tibiofemoral joint. This case highlights the importance of correcting secondary changes, such as valgus deformity and leg-length discrepancy, to reduce the risk of future osteoarthrosis and postoperative dislocation, especially when these deformities are substantial.
Histamine H4 Receptor Optimizes T Regulatory Cell Frequency and Facilitates Anti-Inflammatory Responses within the Central Nervous System
Authors: del Rio Roxana , Noubade Rajkumar , Saligrama Naresha , Wall Emma H. , Krementsov Dimitry N. , Poynter Matthew E. , Zachary James F. , Thurmond Robin L. , Teuscher Cory 
Published: December 2011

Abstract
Histamine is a biogenic amine that mediates multiple physiological processes, including immunomodulatory effects in allergic and inflammatory reactions, and also plays a key regulatory role in experimental allergic encephalomyelitis, the autoimmune model of multiple sclerosis. The pleiotropic effects of histamine are mediated by four G protein-coupled receptors, as follows: Hrh1/H1R, Hrh2/H2R, Hrh3/H3R, and Hrh4/H4R. H4R expression is primarily restricted to hematopoietic cells, and its role in autoimmune inflammatory demyelinating disease of the CNS has not been studied. In this study, we show that, compared with wild-type mice, animals with a disrupted Hrh4 (H4RKO) develop more severe myelin oligodendrocyte glycoprotein (MOG)35\x{2013}55-induced experimental allergic encephalomyelitis. Mechanistically, we also show that H4R plays a role in determining the frequency of T regulatory (TR) cells in secondary lymphoid tissues, and regulates TR cell chemotaxis and suppressor activity. Moreover, the lack of H4R leads to an impairment of an anti-inflammatory response due to fewer TR cells in the CNS during the acute phase of the disease and an increase in the proportion of Th17 cells.
The Relationship between the Stages of Exercise Adoption and other Health Behaviors
Authors: Costakis Catherine E. , Dunnagan Tim , Haynes George 
Published: December 2011

Purpose. To examine the relationship between stage of exercise adoption and the practice of other health behaviors. Design. Demographic, socioeconomic, and health behavior data were collected using a cross-sectional mail survey. Data were collected as part of a larger employee benefits research study. Setting. Montana State University-Bozeman, Bozeman, Montana. Subjects. University employees (n = 1269) comprised of 46% men with a mean age of 44 years. Measures. Demographic and socioeconomic data included age, sex, marital status, level of income and education, dependent status, and job classification. Stage of exercise adoption classifications were based on self-reported responses to four exercise statements. The health behaviors included in this study were cigarette and smokeless tobacco use, seat belt use, alcohol use, and use of stress management practices. Logistic regression analysis was used to determine if stage of exercise predicted the presence of each of the health behaviors while controlling for demographic, socioeconomic, and other health behavior variables. Results. The survey response rate was 68%. Respondents in action exercise stage (p = .0367) were less likely to smoke cigarettes than respondents in precontemplation stage of exercise. Respondents in contemplation (p = .0419), preparation (p = .0060), action (p = .0432), and maintenance (p = .0006) were more likely to use seat belts than respondents in precontemplation. Respondents in maintenance (p = .0059) were more likely to use regular stress reduction techniques than respondents in precontemplation. Conclusions. Although longitudinal research is needed to determine any causal relationships, this research suggests that encouraging individuals to become more involved in exercise could indirectly influence other health behaviors. Hence, exercise could be a possible “gateway” behavior toward healthier lifestyle practices.