bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood abuse uncovered in a palliative care audit
Authors: Macpherson Catriona 
Published: November 2009

AbstractObjective:This article aims to highlight potentially high levels of childhood sexual abuse within Cancer and Palliative Care Service users.Methods:During a routine audit, data was collated to quantify a perceived high level of disclosure of pre-existing psychological trauma within the palliative care caseload of a Macmillan Children and Families Therapist. Families comprised adults (generally parents or step-parents), one of whom was terminally ill or recently deceased who had direct responsibility for children and young people aged under 20 years old. Each family had at least two members using the service for advice, emotional support or counselling.Results:A childhood sexual abuse rate of 33% for women and 10% for men was revealed. Of 59 families, 49% had one or more members who had experienced childhood sexual abuse. In addition a further 9% of adults had experienced severe physical and emotional abuse in childhood. Many families had faced multiple trauma.Significance of results:Palliative care clinicians have access to detailed personal and family history during a highly vulnerable transition. While confidentiality is paramount it is essential to develop better data collection methods and raise the profile of childhood sexual abuse as a major contributing factor to morbidity. A whole family assessment is crucial to ensure child protection and emotional care for children facing the loss and subsequently bereaved of a parent or a carer. Clinicians must be able to offer a range of approaches which provide distressed patients with a history of childhood abuse some sense of emotional containment at the end of life, a challenge which cannot be overstated.
Applying feminist, multicultural, and social justice theory to diverse women who function as caregivers in end-of-life and palliative home care
Authors: Mackinnon Christopher J. 
Published: November 2009

AbstractObjective:Women are largely responsible for providing care to terminally ill family members at home. The goal of this review is to conceptualize diverse women's experiences in palliative home care from feminist, multicultural, and social justice perspectives.Methods:Peer-reviewed manuscripts were identified using the following databases: CIMAHL, psycINFO, and pubMED. The following search terms were used: women/mothers/daughters, Caregiving, family caregivers, feminism, culture, multiculturalism, and palliative home care. Article reference lists were also reviewed. The majority of penitent articles which formed the basis for the arguments presented were drawn from nursing, medicine, and counseling psychology scholarship.Results:The application of feminist, multicultural, and social justice theory brings to attention several potential issues female caregivers may experience. First, there exist diverse ways in which women's Caregiving is manifested that tend to correspond with variations in culture, relationship, and age. Second, it is important to attend to changing expectations placed on women as a result of Caregiving at the end of life. Third, the changing power dynamics women may experience in end of life Caregiving are very complex.Significance of results:The principle finding of the review was the highlighting of potential risks that culturally diverse female caregivers are likely to face at the end of life. The application of social justice theory provides a number of implications for practice and policy. Specifically, the identifying significant concerns regarding female caregivers in palliative home care, as well as suggesting ways to appropriately attend to these concerns, and oppression of women is less likely to be perpetuated, specific areas for future research in this domain are identified.
Lightening up before death
Authors: Macleod A.D. (Sandy) 
Published: November 2009

AbstractA lightening, or clearing, of the mental state in the hours or days before death, particularly in those delirious, is occasionally noted by those caring for the dying. Similar phenomena have been described in the natural world and in classical literature. This brief period of lucidity is generally followed by a rapid terminal decline. The author reports on his experience with six cases illustrating this phenomenon. The increasing use of palliative sedation may diminish the possibility of lightening up before death occurring. The theoretical concepts of Hughlings Jackson may provide an explanation for this phenomenon.
Programme de la VIIme Conférence internationale à Saint-Pétersbourg
Authors: de Kroemer O. 
Published: November 2009

Le Comité central russe se fait un devoir de porter à la connaissance des Comités centraux de la Croix-Rouge que l'ordre du jour de la VIIme Conférence internationale, devant se réunir à Saint-Péterbourg le 16 (29) mai 1902, comprendra les questions suivantes:I. Comité central des Sociétés allemandes de la Croix-Rouge:1. L'activité de la Croix-Rouge allemande en temps de paix.
Vaisseaux-ambulances de la Croix-Rouge japonaise
Authors: Dr F.  
Published: November 2009

Nous extrayons d'une lettre adressée au Medical Record par son correspondant du Japon, les informations suivantes sur l'activité maritime de la Croix-Rouge japonaise:Le Japon, dil-il, à la date du 16 août, va se trouver dans des circonstances favorables pour mettre en activité ses deux beaux vaisseaux-hôpitaux de la Croix-Rouge, le Hakuaï Maru et le Kosaï Maru, tous deux affrétés en vue de la guerre avec la Chine. Le Hakuaï Maru est parti à l'avance et a déjà fait quelques voyages; le Dr Iwai, de l'hôpital de la Croix-Rouge de Tokio, en a le commandement; le Kosaï Maru est sous les ordres du Dr S. Suzuki. Ces deux vaisseaux sont équipés très complètement pour le but auquel il sont destinés et il n'y a pas de doute qu'il ne rendent de signalés services autant aux blessés des autres nations qu'à ceux du Japon. En mettant ces vaisseaux au service des flottes et des armées alliées, le vice-amiral Toya a constaté qu'ils sont placés sous le contrôle du Département de la guerre et de la marine, bien qu'équipés et entretenus entièrement par les soins de la Société de la Croix-Rouge japonaise; il a donné par le même acte la garantie que les décisions de la Convention de la Haye de juillet 1899 se rapportant à la Convention de Genève d'août 1864 seront observées, pour autant du moins que les circonstances le permettront. Cette mesure prise par le Japon a été fort appréciée de la part des différents amiraux. Pour le début, la base des opérations sanitaires, en vue de la campagne en Chine, a été fixée à Sascho sur la côte sud.
Avions sanitaires et Convention de la Croix-Rouge (bibliographie)
Authors: Julliot C. 
Published: November 2009

Tel est le titre d'un article que M. le docteur en droit C. Julliot consacre dans la Revue générate de Droit international public. à la question de la recherche et de l'enlèvement des blessés par aéroplanes.La difficulté de découvrir les morts et les blessés du champ de bataille est inhérente à la tactique actuelle consistant, pour l'infanterie, à se disséminer sur un front considérable, à s'avancer par bonds et à se terrer en profitant, pour se dissimuler. de toute ondulation de terrain. Aussi la recherche des blessés a-t-elle, de tout temps, préoccupé le service sanitaire. On y a dressé le chien sanitaire. On se demande se l'avion pourrait y être utilisé.
Blessés du siège de Pékin
Authors: Dr F.  
Published: November 2009

M. Matignon, médecin-major de 2me classe, a fail dans les Archives de médecine et de pharmacie militaires une intéressante relation du siège de Pékin, pendant lequel il a eu à s'occuper des blessés et malades de la légation de France.La petite armée de défense des légations ne se composait que de 400 soldats de nationalités diverses et de 50 volontaires ; 3 médecins seulement, un Français, un Japonais et un Américain, se trouvaient dans le quartier assiégé. Un petit hôpital fut organisé avec des ressources très limitées et presque sans objets de pansements.
Conférence du 26 au 29 Octobre 1863
Authors: Bogaïewsky P. 
Published: November 2009

I. Histoire de la Conférence internationale (non diplomatique) de Genève du 26 au 29 octobre 1863.1. Parmi les personnes qui, sous l'influence de l'œuvre de Miss Nightingale, appréciaient la haute importance de l'organisation des secours aux militaires blessés, se trouvait le Genevois Henry Dunant. En 1859, M. Henry Dunant part pour l'Italie; il assiste à la terrible journée de Solferino (24 juin) qui laissa sur le champ de bataille 40,000 soldats.
Statuts de la Société uruguayenne de la Croix-Rouge
Authors: de Segarra Aurélia Ramos , Morena Camila 
Published: November 2009

Article premier. — La Croix-Rouge des Dames chrétiennes, fondée en 1897, change son titre contre celui de Croix-Rouge uruguayenne, afin que cette association, établie dans la République orientale de l'Uruguay, soit en dehors de tout parti politique.Son seul objet est de contribuer par tous les moyens possibles au secours des blessés et malades sur le champ de bataille, dans les ambulances et dans les hôpitaux de terre ou de mer.Elle agit de concert avec l'autorité militaire.
Risikofaktoren für Stürze und sturzbedingte Verletzungen im Akutspital – Eine retrospektive Fall-Kontroll-Studie
Authors: Müller Rita , Halfens Ruud , Schwendimann René , Müller Marianne , Imoberdorf Reinhard , Ballmer Peter E. 
Published: November 2009

Stürze von Patienten sind im Akutspital häufige Ereignisse und problematisch wegen direkter und indirekter Folgen. Ziel der Studie war es, vorhersagbare Risikofaktoren für Stürze und sturzbedingte Verletzungen bei Patienten einer akut-medizinischen Klinik in der Schweiz durch eine retrospektive Fall-Kontroll-Studie zu finden. Die Fallgruppe beinhaltete 228 gestürzte Patienten und die Kontrollgruppe 228 nicht gestürzte Patienten, welche gemäß Geschlecht, Alter und medizinischer Diagnose paarweise übereinstimmten. Eine weitere Analyse der Fallgruppe verglich verletzte mit unverletzten Patienten. Die Daten sind der Patientenakte und dem Hospital Information System (HIS) entnommen. In der Fallgruppe waren Patienten mit einem früheren Sturz, einer Mobilitätsstörung, veränderter Kognition, veränderter Urin- und Stuhlausscheidung, Einnahme von Sedativa oder anderer Psychopharmaka, einer höheren Anzahl von Nebendiagnosen und einem höheren Casemix sowie einer längeren Hospitalisationsdauer signifikant häufiger zu beobachten als in der Kontrollgruppe. Keine Unterschiede zeigten die Patienten der Fall- und Kontrollgruppe in Bezug auf Sehstörung, Einnahme von fünf und mehr Medikamenten sowie der Einnahme von Diuretika. Mithilfe einer logistischen Regressionsanalyse konnten Mobilitätsstörung (OR 5,2; 95 % VI 2,39–11,44), veränderte Ausscheidung (OR 1,8; 95 % VI 1,02–3,31) sowie Wechselwirkungen zwischen einem früheren Sturz, einer veränderten Kognition, der Einnahme von Sedativa oder Psychopharmaka als wichtige Einflussgrößen für die Wahrscheinlichkeit eines Sturzes ermittelt werden. Hingegen konnte zwischen verletzten und nicht verletzten Patienten bei keiner der untersuchten Variablen ein signifikanter Unterschied festgestellt werden. Demzufolge konnte also ein prädikatives Profil für sturzgefährdete Patienten gefunden werden, welches hilfreich für die Sturzprävention ist. Hingegen bleibt die Frage nach Risikofaktoren für sturzbedingte Verletzungen unbeantwortet.
High-resolution imaging of pelagic bacteria by Atomic Force Microscopy and implications for carbon cycling
Authors: Malfatti Francesca , Samo Ty J , Azam Farooq 
Published: November 2009

Abstract
In microbial oceanography, cell size, volume and carbon (C) content of pelagic bacteria and archaea (‘bacteria’) are critical parameters in addressing the in situ physiology and functions of bacteria, and their role in the food web and C cycle. However, because of the diminutive size of most pelagic bacteria and errors caused by sample fixation and processing, an accurate measurement of the size and volume has been challenging. We used atomic force microscopy (AFM) to obtain high-resolution images of pelagic bacteria and Synechococcus. We measured the length, width and height of live and formalin-fixed pelagic bacteria, and computed individual cell volumes. AFM-based measurements were compared with those by epifluorescence microscopy (EFM) using 4′,6-diamidino-2-phenylindole (DAPI). The ability to measure cell height by AFM provides methodological advantage and ecophysiological insight. For the samples examined, EFM (DAPI)-based average cell volume was in good agreement (1.1-fold) with live sample AFM. However, the agreement may be a fortuitous balance between cell shrinkage due to fixation/drying (threefold) and Z-overestimation (as EFM does not account for cell flattening caused by sample processing and assumes that height=width). The two methods showed major differences in cell volume and cell C frequency distributions. This study refines the methodology for quantifying bacteria-mediated C fluxes and the role of bacteria in marine ecosystems, and suggests the potential of AFM for individual cell physiological interrogations in natural marine assemblages.
Robust biomarker identification for cancer diagnosis with ensemble feature selection methods
Authors: Abeel Thomas , Helleputte Thibault , Van de Peer Yves , Dupont Pierre , Saeys Yvan 
Published: November 2009

AbstractMotivation: Biomarker discovery is an important topic in biomedical applications of computational biology, including applications such as gene and SNP selection from high-dimensional data. Surprisingly, the stability with respect to sampling variation or robustness of such selection processes has received attention only recently. However, robustness of biomarkers is an important issue, as it may greatly influence subsequent biological validations. In addition, a more robust set of markers may strengthen the confidence of an expert in the results of a selection method.Results: Our first contribution is a general framework for the analysis of the robustness of a biomarker selection algorithm. Secondly, we conducted a large-scale analysis of the recently introduced concept of ensemble feature selection, where multiple feature selections are combined in order to increase the robustness of the final set of selected features. We focus on selection methods that are embedded in the estimation of support vector machines (SVMs). SVMs are powerful classification models that have shown state-of-the-art performance on several diagnosis and prognosis tasks on biological data. Their feature selection extensions also offered good results for gene selection tasks. We show that the robustness of SVMs for biomarker discovery can be substantially increased by using ensemble feature selection techniques, while at the same time improving upon classification performances. The proposed methodology is evaluated on four microarray datasets showing increases of up to almost 30% in robustness of the selected biomarkers, along with an improvement of ∼15% in classification performance. The stability improvement with ensemble methods is particularly noticeable for small signature sizes (a few tens of genes), which is most relevant for the design of a diagnosis or prognosis model from a gene signature.Contact: yvan.saeys@psb.ugent.beSupplementary information: Supplementary data are available at Bioinformatics online.
Extraction and comparison of gene expression patterns from 2D RNA in situ hybridization images
Authors: Mace Daniel L. , Varnado Nicole , Zhang Weiping , Frise Erwin , Ohler Uwe 
Published: November 2009

Abstract
Motivation: Recent advancements in high-throughput imaging have created new large datasets with tens of thousands of gene expression images. Methods for capturing these spatial and/or temporal expression patterns include in situ hybridization or fluorescent reporter constructs or tags, and results are still frequently assessed by subjective qualitative comparisons. In order to deal with available large datasets, fully automated analysis methods must be developed to properly normalize and model spatial expression patterns.
Results: We have developed image segmentation and registration methods to identify and extract spatial gene expression patterns from RNA in situ hybridization experiments of Drosophila embryos. These methods allow us to normalize and extract expression information for 78 621 images from 3724 genes across six time stages. The similarity between gene expression patterns is computed using four scoring metrics: mean squared error, Haar wavelet distance, mutual information and spatial mutual information (SMI). We additionally propose a strategy to calculate the significance of the similarity between two expression images, by generating surrogate datasets with similar spatial expression patterns using a Monte Carlo swap sampler. On data from an early development time stage, we show that SMI provides the most biologically relevant metric of comparison, and that our significance testing generalizes metrics to achieve similar performance. We exemplify the application of spatial metrics on the well-known Drosophila segmentation network.
Availability: A Java webstart application to register and compare patterns, as well as all source code, are available from: http://tools.genome.duke.edu/generegulation/image_analysis/insitu
Contact: uwe.ohler@duke.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Analysis of psoriatic patients registered in Asahikawa Medical College Hospital from 1983 to 2007
Authors: TAKAHASHI Hidetoshi , TAKAHASHI Ichiro , TSUJI Hitomi , IBE Masaki , KINOUCHI Motoshi , HASHIMOTO Yoshio , ISHIDA‐YAMAMOTO Akemi , MATSUO Shinobu , OHKUMA Noritaka , OHKAWARA Akira , IIZUKA Hajime 
Published: November 2009

AbstractPsoriasis is a chronic inflammatory skin disease, which has been increasing during the last 50 years in Japan. The aim of the present study is to analyze psoriatic patients registered from 1983–2007 in Asahikawa Medical College Hospital, which is located in the northern part of Japan. A total of 607 cases were registered at the first inspection in the Department of Dermatology, Asahikawa Medical College. Men (403 cases, 66.4%) were predominant over women (204 cases, 33.6%). The clinical types of psoriasis were psoriasis vulgaris (91.5%), guttate psoriasis (4.2%), psoriasis arthropathica (2.8%), psoriatic erythroderma (0.6%), generalized pustular psoriasis (0.6%), localized pustular psoriasis (0.15%) and infantile psoriasis (0.15%). Topical corticosteroids (78.1%) and vitamin D3 (18.1%) products were the main previous topical agents. Previous systemic treatments included etretinate (7.7%), cyclosporine (1.5%) and methotrexate (0.3%). Use of topical vitamin D3 and cyclosporine therapies have been gradually increasing during the past 25 years. Regarding the previous phototherapy, topical psoralen and ultraviolet A therapy (PUVA) (4.9%) was predominant over ultraviolet B (0.9%), and systemic PUVA (0.7%). Use of ultraviolet B phototherapy has been increasing during the past 5 years. The results are essentially similar to those of a survey of psoriasis in Japan from 1982–2001. Although the incidence of psoriasis might be higher in Hokkaido Prefecture, there is essentially no variation in the disease profile of psoriatic patients.
Adult T‐cell leukemia–lymphoma associated with follicular mucinosis
Authors: WADA Tamae , YOSHINAGA Eiji , OISO Naoki , KAWARA Shigeru , KAWADA Akira , KOZUKA Takehito 
Published: November 2009

AbstractFollicular mucinosis (alopecia mucinosa) is often associated with malignancies including mycosis fungoides and Sézary syndrome, but not adult T‐cell leukemia–lymphoma (ATLL). We report a 49‐year‐old male patient who had pruritic follicular papules and erythemas clinically, and follicular and perifollicular infiltrates and follicular mucin deposition histopathologically. The patient showed 11% of flower‐shaped atypical lymphocytes in blood examination and positive human T‐cell leukemia virus type 1 antibody in serology, consistent with the chronic type of ATLL. This case seems to be a very rare association of follicular mucinosis and chronic ATLL, suggesting that malignant T cells may have a feature of folliculotropism as well as epidermotropism.
Case of autoimmune progesterone dermatitis presenting as fixed drug eruption
Authors: ASAI Jun , KATOH Norito , NAKANO Mayu , WADA Makoto , KISHIMOTO Saburo 
Published: November 2009

AbstractAutoimmune progesterone dermatitis is a rare disorder that presents as a cyclical cutaneous eruption during the luteal phase of the menstrual cycle. It typically occurs in women due to an autoimmune phenomenon to endogenous progesterone production. We describe a 34‐year‐old woman with an erythematous round plaque with blistering, which recurred a few days before her menstrual cycle, at the identical site on the left arm. The diagnosis of autoimmune progesterone dermatitis is made with i.d. skin testing on the affected lesion with progesterone. After the beginning of oral prednisolone (40 mg daily) therapy during menstruation, although slight recurrence appeared, the severity was significantly improved.
Genetic variation in the β, β‐carotene‐9′, 10′‐dioxygenase gene and association with fat colour in bovine adipose tissue and milk
Authors: Tian R. , Pitchford W. S. , Morris C. A. , Cullen N. G. , Bottema C. D. K. 
Published: November 2009

Summaryβ, β‐carotene‐9′, 10′‐dioxygenase (BCO2) plays a role in cleaving β‐carotene eccentrically, and may be involved in the control of adipose and milk colour in cattle. The bovine BCO2 gene was sequenced as a potential candidate gene for a beef fat colour QTL on chromosome (BTA) 15. A single nucleotide base change located in exon 3 causes the substitution of a stop codon (encoded by the A allele) for tryptophan80 (encoded by the G allele) (c. 240G>A, p.Trp80stop, referred to herein as SNP W80X). Association analysis showed significant differences in subcutaneous fat colour and beta‐carotene concentration amongst cattle with different BCO2 genotypes. Animals with the BCO2 AA genotype had more yellow beef fat and a higher beta‐carotene concentration in adipose tissues than those with the GA or GG genotype. QTL mapping analysis with the BCO2 SNP W80X fitted as a fixed effect confirmed that this SNP is likely to represent the quantitative trait nucleotide (QTN) for the fat colour‐related traits on BTA 15. Moreover, animals with the AA genotype had yellower milk colour and a higher concentration of beta‐carotene in the milk.