bluuebunny/crossref_metadata_2025_split huggingface dataset:
Island Hopping in the Ionian Sea: Exploring the Value of Monumental Olive Trees for Sustainable Tourism
Authors: Martinis Aristotelis , Minotou Charikleia , Botonis Athanasios , Kabassi Katerina 
Published: May 2024

AbstractThe monumental olive groves of the Ionian Islands constitute invaluable ecosystems with rich natural and cultural heritage, intertwined perennially with the region’s history. This research highlights the potential to contribute to the sustainable development and tourism of the Ionian Islands, by showcasing unique biodiversity and cultural traditions. Moreover, significant importance has the involvement of local communities in the promotion of sustainable development. The research integrates scientific research and practical applications, and proposes new prospects through the creation of innovative and sustainable initiatives, with immediate feedback to local communities. The proposals, challenges and applications are following the institutional framework and international practices for the preservation of natural and cultural wealth, particularly in NATURA 2000 areas. Design and digital mapping of ecotourism network trails have been conducted within the monumental olive groves of the Ionian Islands. These trails highlight the unique natural monuments that continue to produce olive oil of valuable nutrition. The visit to these natural open sculpture “eco-museums” offer the opportunity to interpret the unique dynamic of nature which connects the history, traditions, customs, and local communities and contributes to a sustainable rural tourism model. The interconnection of the trails of different islands in one holistic approach offers the possibility to enhance a common narrative which could be independent for each island or multiparametric for different islands. Island hopping promotes and interprets different characteristics of each island, in a common base, the monumental olive groves.
Exploring the Motivation to Follow Small Brands on Social Media
Authors: Grigoriadou Maria , Konidaris Agisilaos 
Published: May 2024

AbstractSocial media have impacted numerous aspects of consumers’ social life, including consumer behavior and the consumer—brand relationship. Consumer behavior is evolving though social platforms and is shaping the perceptions and the actions of customers towards brands. As a result, more and more brands are seeking visibility through social networks, establishing an online presence, trying to trigger interaction and engagement with consumers. This paper explores consumer motivation to interact and engage with small travel brands on social media and highlights elements of the brands that make them more appealing to consumers. The paper also identified consumer attributes that make them more willing to engage with small travel brands on social media. The findings of this paper help map the factors that play a key role on the intention of a consumer to follow and engage with a small brand, while there are clear strategies indicated on how a small brand can meet the consumers’ expectations and leverage on potential cross sell opportunities. The research outputs indicate that there are distinct follower groups in terms of interaction with travel brands with unique characteristics that can be leveraged for a more effective brand positioning. In addition, there are remarkable findings on the repetitive nature of buying behavior for people following small travel brands and the potential cross sell opportunities that arise. The findings of this paper may be considered as a roadmap for small brands to improve customer engagement and consumer buying behavior.
Wine Tourism: A Complex Tangible, Intangible and Experiential Marketing Matrix
Authors: Vrasida Maria 
Published: May 2024

AbstractDuring the past decades, wine has been highly associated with tourism, as part of a fine dining and hospitality experience but also in the production phase and the wineries. Wine can present the link between agritourism referring to the actual cultivation process of grapes, to traditional productive activities in the wine production phase, to luxury and fine dining in the consumption phase. Food and wine production are closely linked to the culture and traditions of a particular local context and are the result of a know-how that has been developed locally and passed down over time. Wine is the product that allows for the strongest links and ties with the food and territory of origin. This is evident not only in terms of geography, but also includes the historical and cultural aspects, even aspects of the local climate. Realizing the multiple benefits that can be achieved via such linkages, many wine regions worldwide have encouraged the creation of synergies between the wine and the tourism industry. This mutual cooperation falls under a complex leisure experience comprising of tangible, intangible and experiential elements. The aim of this study is to identify the importance and the level of participation of tangible, intangible and experiential elements in the marketing of wine tourism experiences and the role of wine tourism for its wider region.
Essential mathematics
Authors: Rapp Christoph 
Published: May 2024

AbstractPart I, Fundamentals and derivations, starts with Chapter 2, where mathematical basics that are elementary for the understanding of the content of the book as well as conventions are discussed. Its content covers a description of scalars, vectors and tensors and their mathematical combinations as well as Euler’s and Lagrange’s perspective on a problem. Some basics of functional analysis are described in the context of kinematics. Chapter 2 ends with fluid mechanical terminology.
Axion domain walls, small instantons, and non-invertible symmetry breaking
Authors: Córdova Clay , Hong Sungwoo , Wang Lian-Tao 
Published: May 2024

Abstract
Non-invertible global symmetry often predicts degeneracy in axion potentials and carries important information about the global form of the gauge group. When these symmetries are spontaneously broken they can lead to the formation of stable axion domain wall networks which support topological degrees of freedom on their worldvolume. Such non-invertible symmetries can be broken by embedding into appropriate larger UV gauge groups where small instanton contributions lift the vacuum degeneracy, and provide a possible solution to the domain wall problem. We explain these ideas in simple illustrative examples and then apply them to the Standard Model, whose gauge algebra and matter content are consistent with several possible global structures. Each possible global structure leads to different selection rules on the axion couplings, and various UV completions of the Standard Model lead to more specific relations. As a proof of principle, we also present an example of a UV embedding of the Standard Model which can solve the axion domain wall problem. The formation and annihilation of the long-lived axion domain walls can lead to observables, such as gravitational wave signals. Observing such signals, in combination with the axion coupling measurements, can provide valuable insight into the global structure of the Standard Model, as well as its UV completion.
Nimodipine as Vasodilator in Guide Catheter Flush to Prevent Vasospasm During Endovascular Stroke Treatment
Authors: Sommer Louisa J. , Jesser Jessica , Nikoubashman Omid , Nguyen Thanh N. , Pinho Joao , Reich Arno , Wiesmann Martin , Weyland Charlotte S. 
Published: May 2024

Abstract
Purpose
The clinical importance and management of vasospasm as a complication during endovascular stroke treatment (EVT) has not been well studied. We sought to investigate the effect of adding nimodipine to the guiding catheter flush (GCF) to prevent vasospasm during EVT.

Methods
This is a single-center retrospective analysis including patients with EVT (stent-retriever and/or distal aspiration) treated for anterior or posterior circulation intracranial vessel occlusion from January 2018 to June 2023. Exclusion criteria were intracranial or extracranial stenosis, intra-arterial alteplase, patient age over 80 years. Study groups were patients with (nimo+) and without (nimo−) nimodipine in the GCF. They were compared for occurrence of vasospasm as primary endpoint and clinical outcome in univariate analysis.

Results
477 patients were included in the analysis (nimo+ n = 94 vs. nimo− n = 383). Nimo+ patients experienced less vasospasm during EVT (e.g. vasospasm in target vessel n (%): nimo− = 113 (29.6) vs. nimo+ = 9 (9.6), p < 0.001; extracranial vasospasm, n (%): nimo− = 68 (17.8) vs. nimo+ = 7 (7.4), p = 0.017). Patients of the two study groups had a comparable clinical outcome (90 day mRS, median (IQR): 3 (1–6) for both groups, p = 0.896). In general, patients with anterior circulation target vessel occlusion (TVO) experienced more vasospasm (anterior circ. TVO 38.7% vs. posterior circ. 7.5%, p = 0.006).

Conclusion
Prophylactic adding of nimodipine reduces the risk of vasospasm during EVT without affecting the clinical outcome. Patients with anterior circulation TVO experienced more vasospasm compared to posterior circulation TVO.
Nachwuchsmangel in der Thoraxchirurgie
Authors: Rösch Romina Maria , Griffo Raffaella , Berger-Groch Josephine , Brendel Lena , Presotto Maria Ada , Metelmann Isabella , Winter Hauke , Klotz Laura Valentina 
Published: May 2024

ZusammenfassungHintergrund: Obwohl die Thoraxchirurgie ein anspruchsvolles und vielseitiges chirurgisches Fachgebiet ist, wird in den kommenden Jahren ein Mangel an qualifizierten und motivierten Assistenzärzten für die Thoraxchirurgie erwartet. Es wird mit einem Mangel von ca. 7300 Chirurgen in der stationären Versorgung gerechnet. Daher ist es dringend erforderlich, mehr interessierte junge Medizinstudierende zu gewinnen und die medizinische Ausbildung unserer nächsten Generation von Chirurgen zu verbessern.Methoden: Eine Onlineumfrage mit 39 Fragen zur Demografie der Teilnehmer, medizinischen Ausbildung, zum Interesse an der chirurgischen Ausbildung und der thoraxchirurgischen Weiterbildung sowie zur Attraktivität der Facharztausbildung wurde erstellt, um den aktuellen bundesweiten Status quo unter Medizinstudierenden zu evaluieren.Ergebnisse: Insgesamt konnten 224 Fragebögen zur Auswertung herangezogen werden. Grundsätzlich zeigte sich zu Beginn des Studiums ein hohes Interesse an der (Thorax-)Chirurgie. Hervorzuheben ist, dass ein Drittel nicht wusste, dass der „Thoraxchirurgische-Facharzt“ ein eigenständiger Facharzt ist. Diese Aussage wirft weitere Fragen bzgl. der Präsenz der Thoraxchirurgie im Medizinstudium auf. Gefragt nach typischen Eigenschaften, die die Studierenden mit der Thoraxchirurgie verbinden, wurde zum Großteil mit „einer hohen praktischen Tätigkeit“ geantwortet. Was sie von einer chirurgischen Weiterbildung abhält, wurde vorrangig mit der schlechten Vereinbarkeit von Familie und Beruf begründet.Schlussfolgerung: Die Studierenden wissen genau, was sie sich für ihre Zukunft wünschen und wo die Chirurgie ihre Schwachpunkte hat. Sie wünschen sich eine transparente und praxisorientierte Weitbildung, die Vereinbarkeit von Familie und Beruf sowie die Anerkennung ihrer Arbeit und Person.
USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis
Authors: Liu Han , Gan Qiang , Lai Yongping , Pan Zhenhui , Jin Qifang , Li Jiayue , Wang Nanye , Jiao Shoufeng , Chai Yong 
Published: May 2024

AbstractThe aim of this study is to explore the function of USP14 on the sensitivity of retinoblastoma (RB) to cisplatin (DDP) and the underlying mechanism. USP14 was knockdown in Y79 cells by transfecting three siRNAs (si-USP14-1, si-USP14-2, and si-USP14-3), with si-USP14 NC as the negative control. si-USP14-3 was selected by results of Western blotting. The CCK-8 assay was used to detect the IC50 of Y79 cells and the growth curve. The cell cycle, cell apoptosis, and ROS level were measured by flow cytometry. The expression level of P-GP, ERCC1, survivin, GPX4, FTH1, ACSL4, NOX1, COX2, and FASN was determined by the Western blotting assay. CO-IP assay was utilized to evaluate the interaction between USP14 and FASN. The IC50 of DDP in Y79 cells and Y79/DDP cells was 7.83 µM and 24.67 µM, respectively. Compared to control and si-USP14 NC groups, increased apoptotic rate and ROS level, and arrested cell cycle in S phase were observed in USP14-knockdown Y79 cells. Compared to control and si-USP14 NC groups, increased apoptotic rate and arrested cell cycle in G0/G1 phase were observed in USP14-knockdown Y79/DDP cells. Compared to control, increased ROS level was observed in USP14-knockdown Y79/DDP cells. Compared to the si-USP14 NC groups, extremely downregulated P-GP, ERCC1, survivin, GPX4, FTH1, NOX1, COX2, and FASN were observed in USP14-knockdown Y79 cells or Y79/DDP cells, accompanied by the elevated expression of ACSL4. The interaction between USP14 and FASN was identified according to the result of CO-IP assay. By silencing USP14 in Y79 and Y79/DDP cells, levels of resistance-related proteins (P-GP, ERCC1, and survivin), ferroptosis-related proteins (FTH1 and GPX4), and lipid metabolism-related proteins (NOX1, COX2, and FASN) were dramatically reduced, accompanied by enhanced ROS level, increased apoptosis, and restrained DNA content, indicating that USP14 might suppress the DDP resistance in RB by mediating ferroptosis, which is an important target for treating RB.
An arterial map of the uterine artery - a tool for endovascular and gynecological procedures
Authors: Konarska-Włosińska Monika , Yika Alicia Del Carmen , Dziedzic Martyna , Bonczar Michał , Ostrowski Patryk , Wojciechowski Wadim , Walocha Jerzy , Koziej Mateusz 
Published: May 2024

Abstract
Introduction
The anatomy of the uterine artery (UA) is highly complex, demonstrating various patterns of origin and course. The main objective of the present study is to provide the first anatomical heat map of the UA, demonstrating the location of its origin and course in the pelvis.

Methods
In July 2022, an assessment was conducted on the findings from 40 consecutive female patients who had undergone computed tomography angiography of the abdomen and pelvis. Morphometric features of the UA and its associated anatomical area were gathered in 19 categories.

Results
The presented results are based on a total of 58 UAs. 40 UAs originated from the anterior trunk of the internal iliac artery (69.0%), 16 of the UAs originated from the umbilical artery (27.6%), and the remaining two originated from the inferior gluteal artery (3.4%). The median diameter of the UA at its origin was found to be 3.20 mm (LQ = 2.63; HQ = 3.89).

Conclusion
The anatomy of the UA is highly complex, showcasing variable topography, origin patterns, and morphometric properties. In the present study, a novel arterial map of this vessel was made, highlighting the diversity in its origin location and course. In our studied cohort, the UA originated most commonly from the anterior trunk of the internal iliac artery (69.0%), as described in the major anatomical textbooks. Having adequate knowledge about the anatomy of this artery is of immense importance in various gynecological and endovascular procedures, such as hysterectomies and embolizations.
Global burden of mesothelioma attributable to occupational asbestos exposure in 204 countries and territories: 1990–2019
Authors: Chen Zhiming , Cai Yikuan , Ou Tongyin , Zhou Hu , Li Huajie , Wang Zhizhi , Cai Kaican 
Published: May 2024

AbstractMalignant mesothelioma, a rare and aggressive cancer primarily caused by occupational asbestos exposure, has a poor prognosis. This study leverages the Global Burden of Disease (GBD) 2019 dataset to analyze the burden of mesothelioma linked to occupational asbestos exposure from 1990 to 2019. The analysis includes the number of mesothelioma deaths and disability-adjusted life years (DALYs) attributable to occupational asbestos exposure, focusing on trends in age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life-year rate (ASDR) by year, age, sex, country, region, and Socio-demographic Index (SDI). In 2019, 91.7% of mesothelioma deaths and 85.2% of DALYs were attributable to occupational asbestos exposure, resulting in 26,820 (95% UI 24,312–28,622) deaths and 569,429 (95% UI 509,956–617,484) DALYs. Despite a decline in ASMR and ASDR from 1990 to 2019, the absolute number of deaths and DALYs almost doubled. The United States reported the highest number of mesothelioma deaths, while China had the highest number of DALYs. Age-specific mortality rates and DALYs decreased in the 25–74 age group but increased in the 75+ age group. In conclusion, occupational asbestos exposure remains the primary cause of mesothelioma worldwide, with an increasing number of deaths and DALYs. The highest incidence rates are observed in high-income areas, and rates are rising in low-income areas. It is crucial to raise awareness about the hazards of asbestos to reduce the global burden of mesothelioma linked to occupational exposure.
Lightweight diffusion models: a survey
Authors: Song Wei , Ma Wen , Zhang Ming , Zhang Yanghao , Zhao Xiaobing 
Published: May 2024

AbstractDiffusion models (DMs) are a type of potential generative models, which have achieved better effects in many fields than traditional methods. DMs consist of two main processes: one is the forward process of gradually adding noise to the original data until pure Gaussian noise; the other is the reverse process of gradually removing noise to generate samples conforming to the target distribution. DMs optimize the application results through the iterative noise processing process. However, this greatly increases the computational and storage costs in the training and inference stages, limiting the wide application of DMs. Therefore, how to effectively reduce the resource consumption of using DMs while giving full play to their good performance has become a valuable and necessary research problem. At present, some research has been devoted to lightweight DMs to solve this problem, but there has been no survey in this area. This paper focuses on lightweight DMs methods in the field of image processing, classifies them according to their processing ideas. Finally, the development prospect of future work is analyzed and discussed. It is hoped that this paper can provide other researchers with strategic ideas to reduce the resource consumption of DMs, thereby promoting the further development of this research direction and providing available models for wider applications.
Pulmonary 4D-flow MRI imaging in landrace pigs under rest and stress
Authors: Faragli A. , Hüllebrand M. , Berendsen A. J. , Solà L. Tirapu , Lo Muzio F. P. , Götze C. , Tanacli R. , Doeblin P. , Stehning C. , Schnackenburg B. , Van der Vosse F. N. , Nagel E. , Post H. , Hennemuth A. , Alogna A. , Kelle Sebastian 
Published: May 2024

Abstract4D-flow MRI is a promising technique for assessing vessel hemodynamics. However, its utilization is currently limited by the lack of reference values, particularly for pulmonary vessels. In this work, we have analysed flow and velocity in the pulmonary trunk (PT), left and right pulmonary arteries (LPA and RPA, respectively) in Landrace pigs at both rest and stress through the software MEVISFlow. Nine healthy Landrace pigs were acutely instrumented closed-chest and transported to the CMR facility for evaluation. After rest measurements, dobutamine was administered to achieve a 25% increase in heart rate compared to rest. 4D-flow MRI images have been analysed through MEVISFlow by two independent observers. Inter- and intra-observer reproducibility was quantified using intraclass correlation coefficient. A significant difference between rest and stress regarding flow and velocity in all the pulmonary vessels was observed. Mean flow increased 55% in PT, 75% in LPA and 40% in RPA. Mean peak velocity increased 55% in PT, 75% in LPA and 66% in RPA. A good-to-excellent reproducibility was observed in rest and stress for flow measurements in all three arteries. An excellent reproducibility for velocity was found in PT at rest and stress, a good one for LPA and RPA at rest, while poor reproducibility was found at stress. The current study showed that pulmonary flow and velocity assessed through 4D-flow MRI follow the physiological alterations during cardiac cycle and after stress induced by dobutamine. A clinical translation to assess pulmonary diseases with 4D-flow MRI under stress conditions needs investigation.
From one crisis to another: the European central bank’s role from the great recession to the Ukraine war
Authors: Chesini Giusy , Fauri Francesca 
Published: May 2024

AbstractThe paper examines the changing role of the European Central Bank over the last 15 years and holds that the ECB has gone through a process of learning by doing, relying on earlier crisis experiences in forming its response to successive crises. This learning process has enabled it to sustain the euro countries against various exogenous shocks both within the power of its mandate and beyond it, implementing novel reforms. We argue, in fact, that crises stimulated institutional innovations such as the introduction of Eurozone banking supervision and the European Banking Union. The latter was a particularly ground-breaking idea, not contemplated by the Treaties, and addressed to exceptional endogenous dynamics. During the last two emergencies, triggered by the pandemic and the war, the ECB seems finally to have learned how to manage crises via a synergic use of available tools.
Maternal Behavior in Sumatran Orangutans (Pongo abelii) is Modulated by Mother-Offspring Characteristics and Socioecological Factors
Authors: Revathe T. , Mundry Roger , Utami-Atmoko Sri Suci , Perawati Deana , Bürkner Paul-Christian , van Noordwijk Maria A. , Schuppli Caroline 
Published: May 2024

AbstractMammalian mothers flexibly invest in their offspring to maximize their lifetime fitness. Flexible maternal investment may be particularly important in large-brained species with prolonged maternal care, e.g., in great apes. We investigated the effects of socioecological factors and mother–offspring characteristics on nine maternal behaviors in wild Sumatran orangutans (Pongo abelii; N = 22 mother-offspring pairs; >11,200 hr of focal data from 2007–2022) using generalized linear mixed models. The behaviors fall under four maternal functions: locomotory support (carrying), skill acquisition support (feeding in proximity, food transfer), protective proximity maintenance (body contact and proximity initiation, following), and independence promotion (body contact and proximity termination, avoiding). Mother’s parity was not significantly associated with any maternal behavior. Mothers were more likely to show locomotory support, skill acquisition support, and protective proximity maintenance toward younger than older offspring, whereas they were more likely to promote independence in older than younger offspring. Mothers with male offspring were more likely to show skill acquisition support to their offspring than those with female offspring. With increasing food availability, skill acquisition support reduced. With increasing association size (i.e., the number of individuals within 50 m of each other), mothers were more likely to show protective proximity maintenance and less likely to promote independence. When males were present, mothers were more likely to show locomotory support to their offspring. Sumatran orangutan mothers thus flexibly adjust offspring-directed behavior in response to prevailing socioecological factors and mother–offspring characteristics. Our findings add support to the evolutionary theory that mammalian mothers flexibly invest in their offspring.