bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change in Psychosocial Distress Associated With Pain and Functional Status Outcomes in Patients With Lumbar Impairments Referred to Physical Therapy Services
Authors: Werneke Mark W. , Hart Dennis L. , George Steven Z. , Deutscher Daniel , Stratford Paul W. 
Published: February 2012

Study Design Prospective, longitudinal, observational cohort design. Objective The primary aim was to examine the association between changes in psychosocial distress (PD), and functional status (FS) and pain intensity at discharge from physical therapy. Background Patients with lumbar impairments seeking physical therapy commonly demonstrate elevated PD. However, it is not clear if PD changes that occur during physical therapy management are associated with improved clinical outcomes. Methods Data from adults (n = 692) with lumbar impairment were analyzed. Patients were screened using the Symptom Checklist Back Pain Prediction Model questionnaire (SCL BPPM) to identify patients at intake and discharge into 3 levels of risk for persistent disability (high, intermediate, or low). SCL BPPM classifications allowed for 5 patterns of change in PD during therapy (decreased, stable low, stable intermediate, stable high, or increased). Associations between PD change patterns and discharge FS and pain intensity were assessed using multivariable linear regression models, controlling for selected risk-adjustment variables. Results Proportions of patients classified by patterns of PD change for decreased, stable low, stable intermediate, stable high, and increased were 0.34, 0.52, 0.05, 0.06, and 0.03, respectively. Compared to the decreased PD group, (1) increased, stable high, and stable intermediate PD patterns were associated with worse discharge FS scores (−7.9 [95% CI: −13.5, −2.21], −10.9 [95% CI: −15.25, −6.49], and −8.9 [95% CI: −13.65, −4.21] units, respectively), and (2) stable high and stable intermediate PD patterns were associated with higher pain intensity (2.59 [95% CI: 1.81, 3.56] and 2.14 [95% CI: 1.25, 3.04] units, respectively). Conclusions Lower FS and higher pain intensity outcomes were associated in similar but not identical patterns with patients whose SCL BPPM classification of PD increased, or remained at high or intermediate levels during physical therapy. Serial assessments of change in PD during rehabilitation are recommended as a possible treatment-monitoring tool. J Orthop Sports Phys Ther 2011;41(12):969–980. doi:10.2519/jospt.2011.3814
Physical Therapy in a Value-Based Healthcare World
Authors: Fritz Julie M. 
Published: February 2012

Musculoskeletal conditions are important contributors to United States healthcare spending and are certain to play an important role in the future as the population continues to age. Almost half of the population of the United States experiences a musculoskeletal condition annually. Meeting the needs of these individuals within a changing healthcare delivery and reimbursement environment prompted a recent Summit sponsored by the United States Bone and Joint Initiative (USBJI). The Summit dealt with a topic critical to the future of healthcare for clinicians, consumers, and payers alike: value. We do not operate within a value-based healthcare system. Our current delivery system continues to reward volumes, not value. Failure to focus on value has had devastating consequences. The challenge of shifting from a volume-based to a value-based system is central to the future of healthcare. Discussion and action will be critical for the physical therapy profession moving into the future. J Orthop Sports Phys Ther 2012;42(1):1–2. doi:10.2519/jospt.2012.0101
The FIT-HaNSA Demonstrates Reliability and Convergent Validity of Functional Performance in Patients With Shoulder Disorders
Authors: Kumta Prajyot , MacDermid Joy C. , Mehta Saurabh P. , Stratford Paul W. 
Published: February 2012

Study Design Psychometric study design. Objectives To assess the test-retest reliability and convergent validity of the Functional Impairment Test-Hand and Neck/Shoulder/Arm (FIT-HaNSA) in patients with shoulder disorders. Background Performance tests that assess functional ability of patients with shoulder disorders can provide useful information for making clinical or return-to-activity decisions. No performance-based shoulder test has yet demonstrated sufficient relevance or clinical measurement properties. The FIT-HaNSA examines upper extremity performance during repetitive tasks that emphasize shoulder reaching and static postures and, therefore, has greater relevance for assessing performance. Methods Thirty-six patients with shoulder disorders and 65 healthy controls were recruited for the study. The FIT-HaNSA, the Disabilities of the Arm, Shoulder and Hand questionnaire, the Shoulder Pain and Disability Index, isometric shoulder strength, and shoulder range of motion were assessed at baseline and repeated 2 to 7 days later. Test-retest reliability was described using intraclass correlation coefficient (ICC2,1) and standard error of measurement. Pearson correlation coefficients were used to examine the level of association between the FIT-HaNSA scores and the other measures. Results The ICCs for test-retest reliability for the FIT-HaNSA ranged from 0.89 to 0.97 in the patient group and 0.79 to 0.91 in the control group. The FIT-HaNSA showed high correlation with the Disabilities of the Arm, Shoulder and Hand and the Shoulder Pain and Disability Index, and moderate correlations with shoulder range of motion and muscle strength. Conclusion The FIT-HaNSA demonstrated high test-retest reliability and convergent validity with other related outcomes in patients with shoulder disorders. Further longitudinal studies are required to evaluate the responsiveness of the FIT-HaNSA in patients with different upper extremity conditions. J Orthop Sports Phys Ther 2012;42(5):455–464, Epub 25 January 2012. doi:10.2519/jospt.2012.3796
Management of Dancers With Symptomatic Accessory Navicular: 2 Case Reports
Authors: Smith Teresa Riemer 
Published: February 2012

Study Design Case report. Background Symptomatic accessory navicular can be a source of pain and disability. The treatment considerations for accessory navicular in dancers may differ due to increased demands on the foot, the repetitive nature of the movements, and the specific footwear required. The purpose of this report is to describe the management (1 conservative and 1 postoperative) of 2 adolescent dancers with symptomatic accessory navicular. Case Descriptions Case 1 was an 11-year-old female who underwent surgical excision of a symptomatic accessory navicular. Case 2 was a 15-year-old female who, following a traumatic injury that caused pain judged to be related to her accessory navicular, was managed nonsurgically. Treatment included pain management, range-of-motion exercises, trunk and lower extremity strengthening, balance and proprioception training, orthoses, crosstraining, and a guided return-to-dance progression. Outcomes Both patients had improved pain, dance technique, strength, and patient-reported outcome scores that allowed a full return to dance. Discussion The 2 dancers presented here had foot pain believed to be related to a symptomatic accessory navicular. In both cases, treatment targeted specific impairments to improve function and disability. The guided progression of activities was intended to facilitate a return to dance that protected healing tissues and prevented a recurrence of symptoms. Clinicians should be aware of the effect of a symptomatic accessory navicular in the young dancer and potentially effective nonsurgical treatment options for this condition. Level of Evidence Therapy, level 4. J Orthop Sports Phys Ther 2012;42(5):465–473, Epub 25 January 2012. doi:10.2519/jospt.2012.3809
Elite Swimmers With Unilateral Shoulder Pain Demonstrate Altered Pattern of Cervical Muscle Activation During a Functional Upper-Limb Task
Authors: Hidalgo-Lozano Amparo , Calderón-Soto Carmen , Domingo-Camara Antonio , Fernández-de-las-Peñas César , Madeleine Pascal , Arroyo-Morales Manuel 
Published: February 2012

Study Design Cross-sectional cohort study. Objective To investigate the differences in the level of activation of neck-shoulder muscles between elite swimmers with and without shoulder pain during a functional upper-limb task. Background Previous studies have reported altered motor control of the neck-shoulder muscles in patients with chronic neck-shoulder pain. Whether the activation of neck-shoulder muscles is altered among elite swimmers who have shoulder pain is unknown. Methods Surface electromyography from the sternocleidomastoid, upper trapezius, and anterior scalene (SCL) muscles was recorded bilaterally in 17 elite swimmers (9 men, 8 women; mean ± SD age, 21 ± 3 years) with unilateral shoulder pain, and 17 age- and sex-matched elite swimmers without pain. Root-mean-square values were calculated and normalized to assess the level of muscular activation 5 seconds before, 120 seconds into, 150 seconds into, and 10 seconds after a functional upper-limb task. Results The data revealed significant differences between groups for the root-mean-square of both SCL muscles (F = 3.733, P = .016) but not for the sternocleidomastoid and upper trapezius muscles. Swimmers with shoulder pain had higher normalized root-mean-square values in both SCL muscles at 120 seconds (78% on average) and 150 seconds (86% on average) into the task and at 10 seconds after the task (40% on average), as compared with swimmers without shoulder pain (P<.05). Conclusion The elite swimmers with shoulder pain demonstrated greater activation of the SCL muscles during a functional task and a lower ability to relax the SCL muscles after completion of the task than elite swimmers without shoulder pain. The present findings suggest an altered pattern of cervical muscle activation in elite swimmers with shoulder pain during performance of a functional task. J Orthop Sports Phys Ther 2012;42(6):552–558, Epub 25 January 2012. doi:10.2519/jospt.2012.3875
Onset, retreat and length of the rainy season over Cameroon
Authors: Guenang G. M. , Mkankam Kamga F. 
Published: February 2012

AbstractObserved precipitation from 24 stations in Cameroon during 1962–1993 were used to study onset, retreat and length of the rainy season. Results were compared to control simulations by four IPCC 4AR AOGCMs. CSIRO‐mk3.5 and MPI‐echam5 AOGCMs best captured onset, retreat and duration of the rainy season. Projections for 2082–2098 under the SRES A2 emission scenario were also analysed. For that period, onset dates are expected to be later by 1 pentad or more than in the current climate and retreat by less than half a pentad in zones 1 and 2. This will lead to a slight decrease in the duration of the rainy season. The situation is reverse in zone 3, where the season will be longer. Copyright © 2012 Royal Meteorological Society
Probing the Structure of Lysozyme–Carbon‐Nanotube Hybrids with Molecular Dynamics
Authors: Calvaresi Matteo , Hoefinger Siegfried , Zerbetto Francesco 
Published: February 2012

AbstractLysozyme has been successfully used to solvate carbon nanotubes (CNT). Extensive molecular dynamics simulations show that 1) a favorite site of adsorption exists, 2) the protein–tube interaction region is located far from the active site, 3) two protein helices act as a tweezer that grips the nanotube, 4) a localized protein re‐arrangement hides the tube from the solvent, and 5) aminic and amidic moieties of lysozyme behave similarly to surfactants in the solvation of the tube.
Incidence of brain metastases as a first site of recurrence among women with triple receptor–negative breast cancer
Authors: Dawood Shaheenah , Lei Xiudong , Litton Jennifer K. , Buchholz Thomas A. , Hortobagyi Gabriel N. , Gonzalez‐Angulo Ana M. 
Published: February 2012

AbstractBACKGROUND:This retrospective study sought to define the incidence of brain metastases as a first site of recurrence among women with triple receptor–negative breast cancer (TNBC).METHODS:A total of 2448 patients with stage I through III TNBC who were diagnosed between 1990 and 2010 were identified. We computed the cumulative incidence of developing brain metastases as a first site of recurrence at 2 and 5 years. Cox proportional hazards models were fitted to determine factors that could predict for the development of brain metastases as a first site of recurrence. The Kaplan‐Meier product limit method was used to compute survival following a diagnosis of brain metastases.RESULTS:At a median follow‐up of 39 months, 115 (4.7%) patients had developed brain metastases as a first site of recurrence. The cumulative incidence at 2 and 5 years was 3.7% (95% confidence interval [CI] = 2.9%‐4.5%) and 5.4% (95% CI = 4.4%‐6.5%), respectively. Among patients with stage I, II, and III disease, the 2‐year cumulative incidence of brain metastases was 0.8%, 3.1%, and 8%, respectively (P < .0001). The 5‐year cumulative incidence was 2.8%, 4.6%, and 9.6% among patients with stage I, II, and III disease, respectively (P < .0001). In the multivariable model, patients with stage III disease had a significant increase in the risk of developing brain metastases as a first site of recurrence (hazards ratio = 3.51; 95% CI = 1.85‐6.67; P = .0001) compared to patients with stage I disease. Those with stage II disease had a nonsignificant increased risk of developing brain metastases as a first site of recurrence (hazards ratio = 1.61; 95% CI = 0.92‐2.81; P = .10) compared with patients with stage I disease. Median survival following a diagnosis of brain metastases was 7.2 months (range, 5.7‐9.4 months).CONCLUSIONS:Patients with nonmetastatic TNBC have a high early incidence of developing brain metastases as a first site of recurrence, which is associated with subsequent poor survival. Patients with stage III TNBC in particular would be an ideal cohort in which to research preventive strategies. Cancer 2012. © 2012 American Cancer Society.
Decreasing radiation therapy utilization in adult patients with glioblastoma multiforme
Authors: Walker Gary V. , Li Jing , Mahajan Anita , McAleer Mary Frances , de Groot John F. , Azeem Syed S. , Brown Paul D. 
Published: February 2012

AbstractBACKGROUND:The purpose of this study was to assess what factors influence radiation therapy (RT) utilization in patients with glioblastoma and to ascertain how patterns of care have changed over time.METHODS:A total of 9103 patients with supratentorial glioblastoma in the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2006 were analyzed. Demographic information was obtained, including age, sex, race, year of diagnosis, and marital status. Treatment characteristics included receipt of RT and surgical resection.RESULTS:In total, 76.8% of patients received RT, whereas 78% received resection. Patients of male sex, who were currently married, who were <65 years old, and who underwent resection were more likely to receive RT. The average annual percentage change in RT utilization in the years 1990‐2006 was −0.41% (95% confidence interval [CI], −0.23 to −0.58), whereas for resection it was 0.26% (95% CI, 0.03 to 0.50). This equates to a 6.5% decrease in RT utilization and a 4.2% increase in resection during this time period. Patients treated with RT had a 2‐year overall survival of 11.4%, compared with 5.2% in those not treated with RT (P < .00001). Multivariate analysis showed that younger age (continuous; odds ratio [OR], 0.97; P < .0001), marital status (OR, 1.62; P < .0001), surgical resection (OR, 1.72; P < .0001), and year of diagnosis 1998‐2006 compared with 1990‐1997 (OR, 0.82; P < .0001) were associated with RT utilization, whereas sex, lesion size, and race were not.CONCLUSIONS:SEER data show a decreasing utilization of RT in patients with glioblastoma from 1990 to 2006. Patients who were older, who were unmarried, and who underwent biopsy only were less likely to receive RT. Cancer 2012. © 2012 American Cancer Society.
Modeling TGF‐mediated flow dynamics in a system of three coupled nephrons
Authors: Bayram Saziye 
Published: February 2012

SUMMARYThis paper focuses on a mathematical model of a system of three closely coupled nephrons and accompanying analytical and computational analysis. In our previous modeling efforts, we have shown how coupling magnifies the tendency of many coupled identical nephrons to oscillate owing to tubuloglomerular feedback (TGF) mechanism. However, in this study, our focus is on the coupled nonidentical nephrons and their dynamics due to the TGF system. Our detailed analytical and computational results suggest that systems of three nonidentical nephrons coupled to their nearest neighbors are prone to be found in an oscillatory state, relative to a single‐nephron case with the same properties; however, their steady‐state regions are not necessarily as small as it was predicted from the system of many coupled identical nephrons cases. Copyright © 2012 John Wiley & Sons, Ltd.
Design and implementation for location‐based integrated GIS application provisioning platform
Authors: Cheng Bo , Yang Qin , Chen Junliang 
Published: February 2012

ABSTRACTMobile geographic information system (GIS) solutions and location‐based services can be considered as the most rapid expanded field of the mobile communications domain that will play a major role in the future. The combination of position‐fixing mechanisms with location and geographically dependent information can offer truly individualised personal communication services through the mobile phone or other type of devices. This paper aims to design, specify and implement an integrated GIS application provision platform, and focuses on the design of integrated service process language and geographic service description language as well as gives the implementation for the integrated GIS service execution container based on location‐based service using service component architecture, which will cater for the full range of issues concerning the provision of location‐based GIS value‐added services. This platform will enable the specification, creation and deployment of such services, which can offer truly individualised personal communication services through mobile phone, and also make performance measurement and analysis. Finally, we give the conclusions and the plan for future work. Copyright © 2012 John Wiley & Sons, Ltd.
Performance enhancement of 2‐D optical CDMA systems using MCM signalling and heterodyne detection receiver
Authors: Pham Anh T. , Dang Ngoc T. 
Published: February 2012

ABSTRACTWe propose 2‐D optical code‐division multiple‐access systems using multi‐code modulation signalling and heterodyne detection receiver. The proposed system's performance is theoretically analysed and compared with conventional ones using on–off keying, pulse–amplitude modulation and pulse–position modulation. The numerical results show that the proposed system outperforms the conventional ones in terms of required transmitted power, the number of supportable users and spectral efficiency. Copyright © 2012 John Wiley & Sons, Ltd.
Using prospective hazard analysis to assess an active shooter emergency operations plan
Authors: Card Alan J. , Harrison Heidi , Ward James , Clarkson P. John 
Published: February 2012

AbstractMost risk management activity in the healthcare sector is retrospective, based on learning from experience. This is feasible where the risks are routine, but emergency operations plans (EOP) guide the response to events that are both high risk and rare. Under these circumstances, it is important to get the response right the first time, but learning from experience is usually not an option. This case study presents the rationale for taking a proactive approach to improving healthcare organizations' EOP. It demonstrates how the Prospective Hazard Analysis (PHA) Toolkit can drive organizational learning and argues that this toolkit may lead to more efficient improvement than drills and exercises.
Conformations and intermolecular interactions pattern in solid chloroxylenol and triclosan (API of anti‐infective agents and drugs). A 35Cl NQR, 1H‐14 N NQDR, X‐ray and DFT/QTAIM study
Authors: Latosińska J. N. , Latosińska M. , Tomczak M. A. , Seliger J. , Žagar V. , Maurin J. K. 
Published: February 2012

Two antibacterial and antifungal agents, chloroxylenol (4‐chloro‐3,5‐dimethyl‐phenol) and triclosan (5‐chloro‐2‐(2’,4’‐dichlorophenoxy)‐phenol), were studied experimentally in solid state with an X‐ray, 35Cl‐nuclear quadrupole resonance (NQR) and 17O‐nuclear quadrupole double resonance (NQDR) spectroscopies and, theoretically, with the density functional theory/quantum theory of atoms in molecules (DFT/QTAIM). The crystallographic structure of triclosan, which crystallises in space group P31 with one molecule in the asymmetric unit [a = 12.64100(10), b = 12.64100(10), c = 6.71630(10) Å], was solved with an X‐ray and refined to a final R‐factor of 2.81% at room temperature. The NQR frequencies of 35Cl and 17O were detected with the help of the density functional theory (DFT) assigned to particular chlorine and oxygen sites in the molecules of both compounds.The NQR frequencies at 35Cl sites in chloroxylenol and triclosan were found to be more differentiated than frequencies at the 17O site. The former better describes the substituent withdrawing effects connected to π‐electron delocalization within the benzene rings and the influence of temperature; whereas, those at the 17O site provide more information on O‐H bond and intermolecular interactions pattern. The conformation adopted by diphenyl ether of triclosan in solid state was found to be typical of diphenyl ethers, but the opposite to those adopted when it was bound to different inhibitors. According to an X‐ray study, temperature had no effect on the conformation of the diphenyl ring of triclosan, which was the same at 90 K and at room temperature (RT). The scattering of NQR frequencies reproduced by the DFT under assumption of the X‐ray data at 90 K and RT is found to be a good indicator of the quality of resolution of the crystallographic structure. Copyright © 2012 John Wiley & Sons, Ltd.
Dichlorodiphenyltrichloroethane determination in air by thermal desorption gas chromatography–mass spectrometry
Authors: Martin Nicholas J , Smith Philip A , Brown Carlis W , Achee Nicole L , DeLong Gerald T 
Published: February 2012

AbstractBACKGROUND: Current quantitative methods for airborne dichlorodiphenyltrichloroethane (DDT) require collection and extraction times of ≥ 12 h. The aim of this study was to develop a method for quantifying airborne DDT with a short (<4 h) collection and analysis time.RESULTS: Precision [relative standard deviation (RSD)] for each calibration point (0.8–9.0), linearity (R2 = 0.99) and apparent recovery (R′ = 96.5%) were determined from thermal desorption (TD) gas chromatography–mass spectrometry (GC‐MS) analyses of Tenax‐TA‐packed sampling tubes spiked with 1–250 ng of DDT. Recovery of 13C‐labeled 4,4′‐DDT from tubes spiked before and after air sampling was 97.3 and 90.3% respectively. DDT was detected and quantified in 1–3 L samples of air collected during 10–180 min sampling events. A significant difference was observed in DDT air concentration between 28 and 33 °C during microchamber studies.CONCLUSIONS: The results demonstrate that the TD GC‐MS method developed in this study is precise, reproducible and linear over the span of 1–250 ng of DDT spiked onto TD tubes. By avoiding dilution of the sample, the method described allows the measurement of DDT vapor concentrations during short sampling periods (10–180 min) relevant to mosquito behavior studies. Published 2012 by John Wiley & Sons, Ltd.