bluuebunny/crossref_metadata_2025_split huggingface dataset:
The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle‐aged and older adults with sarcopenia
Authors: Nie Xin , Wang Chi , Zhang He , Liu Qianhui , Hou Lisha , Deng Yiping , Ye Wenbin , Yue Jirong , He Yong 
Published: June 2024

AbstractObjectiveSarcopenia is a geriatric syndrome that occurs with age and is characterized by a gradual decline in muscle mass, power, and functionality. It serves as a prominent contributor to frailty, disability, and mortality among older individuals. Currently, no standardized global guidelines exist for the diagnosis of sarcopenia. This study aimed to establish the correlation between sarcopenia and the constitutions of traditional Chinese medicine (TCM), considering the connection between physical functioning and sarcopenia.MethodsA total of 1441 participants in this study were diagnosed with sarcopenia. The Asian Working Group for Sarcopenia (AWGS) proposed a sarcopenia definition algorithm. To determine the constitution of each participant, classification and determination standards were used in traditional Chinese medicine. This study evaluated the demographics, lifestyles, and self‐reported medical history of individuals diagnosed with sarcopenia through a self‐administered questionnaire. The constitution of the participants was determined using TCM classification and determination standards. Subsequently, we analyzed the results of univariate analysis and multivariate regression and constructed a receiver operating characteristic (ROC) curve.ResultsParticipants who were diagnosed with sarcopenia had substantially lower original Neutral constitution scores (P < 0.050). In comparison to those without sarcopenia, individuals with sarcopenia exhibited notably elevated original Qi‐deficiency, Yang‐deficiency, Yin‐deficiency, Blood‐stagnation, and Qi‐stagnation scores in contrast to those in the healthy group (P < 0.050). The identified risk factors associated with sarcopenia included the following: Neutral (OR = 0.903), Qi‐deficiency (in males, OR = 1.126), Yang‐deficiency (OR = 1.062), Phlegm‐dampness (in males, OR = 0.833), and Blood‐stagnation (in females, OR = 1.089). The highest area under the curve (AUC) was observed for the original neutral constitution score, followed by the Yang‐deficiency and blood‐stagnation scores (0.644, 0.613, and 0.611, respectively). Additionally, the AUC for the combined original scores of all nine constitutions among males reached 0.778.ConclusionsIn this cross‐sectional study of older people with higher original Qi‐deficiency, Yin deficiency, Yang‐deficiency, Blood‐stagnation, and Qi‐stagnation were associated with sarcopenia. Notably, various TCM constitutions are significantly linked to sarcopenia. There was a significant occurrence of various body constitution types among individuals diagnosed with sarcopenia. The mixture of the nine original constitution scores exhibited good diagnostic performance for sarcopenia in males.
Mechanism and kinetic modeling study on the crystallization of concomitant polymorphs
Authors: Li Si , Wang Zhixuan , Zhang Mingtao , Zhou Lina , Tang Weiwei , Gong Junbo 
Published: June 2024

AbstractConcomitant polymorphs routinely observed in fine chemical industry could impact product purity and consistency; however, both molecular mechanism and process kinetics of concomitant crystallization remain elusive. Herein, we developed a population balance model to understand process kinetics of concomitantly dipolymorphic crystallization using DL‐methionine as a model compound. Kinetic parameters were estimated from induction time measurements and unseeded crystallization experiments. Experimental and simulation results demonstrate that the stable β form has a comparable nucleation rate with α form thanks to their close nucleation barrier leading to the concurrent nucleation. Several solution chemistry techniques were utilized to examine the speciation of solute molecules, together revealing the solutes' self‐association and the formation of micelle‐like aggregates driven by hydrophobic interactions, not hydrogen bonds. These aggregates show dynamic nature against conventional thoughts of classical nucleation kinetics. Finally, the molecular mechanism of concomitant crystallization was uncovered and the implications for polymorph selection and control were discussed.
Photoinduced Group Transposition via Iridium‐Nitrenoid Leading to Amidative Inner‐Sphere Aryl Migration
Authors: Jung Hoimin , Choi Jungkweon , Kim Daniel , Lee Jeong Hoon , Ihee Hyotcherl , Kim Dongwook , Chang Sukbok 
Published: June 2024

AbstractWe herein report a fundamental mechanistic investigation into photochemical metal‐nitrenoid generation and inner‐sphere transposition reactivity using organometallic photoprecursors. By designing Cp*Ir(hydroxamate)(Ar) complexes, we induced photo‐initiated ligand activation, allowing us to explore the amidative σ(Ir–aryl) migration reactivity. A combination of experimental mechanistic studies, femtosecond transient absorption spectroscopy, and density functional theory (DFT) calculations revealed that the metal‐to‐ligand charge transfer enables the σ(N−O) cleavage, followed by Ir‐acylnitrenoid generation. The final inner‐sphere σ(Ir–aryl) group migration results in a net amidative group transposition.
DNA Nanotechnology Targeting Mitochondria: From Subcellular Molecular Imaging to Tailor‐Made Therapeutics
Authors: Yu Fangzhi , Li Xiangfei , Sheng Chuangui , Li Lele 
Published: June 2024

AbstractMitochondria, one of the most important organelles, represent a crucial subcellular target for fundamental research and biomedical applications. Despite significant advances in the design of DNA nanotechnologies for a variety of bio‐applications, the dearth of strategies that enable mitochondria targeting for subcellular molecular imaging and therapy remains an outstanding challenge in this field. In this Minireview, we summarize the recent progresses on the emerging design and application of DNA nanotechnology for mitochondria‐targeted molecular imaging and tumor treatment. We first highlight the engineering of mitochondria‐localized DNA nanosensors for in situ detection and imaging of diverse key molecules that are essential to maintain mitochondrial functions, including mitochondrial DNA and microRNA, enzymes, small molecules, and metal ions. Then, we compile the developments of DNA nanotechnologies for mitochondria‐targeted anti‐tumor therapy, including modularly designed DNA nanodevices for subcellular delivery of therapeutic agents, and programmed DNA assembly for mitochondrial interference. We will place an emphasis on clarification of the chemical principles of how DNA nanobiotechnology can be designed to target mitochondria for various biomedical applications. Finally, the remaining challenges and future directions in this emerging field will be discussed, hoping to inspire further development of advanced DNA toolkits for both academic and clinical research regarding mitochondria.
Bilateral Chemical Linking at NiOx Buried Interface Enables Efficient and Stable Inverted Perovskite Solar Cells and Modules
Authors: Yang Yang , Chen Ruihao , Wu Jiandong , Dai Zhiyuan , Luo Chuanyao , Fang Zhiyu , Wan Shuyuan , Chao Lingfeng , Liu Zhe , Wang Hongqiang 
Published: June 2024

AbstractInverted NiOx‐based perovskite solar cells (PSCs) exhibit considerable potential because of their low‐temperature processing and outstanding excellent stability, while is challenged by the carriers transfer at buried interface owing to the inherent low carrier mobility and abundant surface defects that directly deteriorates the overall device fill factor. Present work demonstrates a chemical linker with the capability of simultaneously grasping NiOx and perovskite crystals by forming a Ni−S−Pb bridge at buried interface to significantly boost the carriers transfer, based on a rationally selected molecule of 1,3‐dimethyl‐benzoimidazol‐2‐thione (NCS). The constructed buried interface not only reduces the pinholes and needle‐like residual PbI2 at the buried interface, but also deepens the work function and valence band maximum positions of NiOx, resulting in a smaller VBM offset between NiOx and perovskite film. Consequently, the modulated PSCs achieved a high fill factor up to 86.24 %, which is as far as we know the highest value in records of NiOx‐based inverted PSCs. The NCS custom‐tailored PSCs and minimodules (active area of 18 cm2) exhibited a champion efficiency of 25.05 % and 21.16 %, respectively. The unencapsulated devices remains over 90 % of their initial efficiency at maximum power point under continuous illumination for 1700 hours.
Hierarchical Solid‐Additive Strategy for Achieving Layer‐by‐Layer Organic Solar Cells with Over 19 % Efficiency
Authors: Chen Qiaoling , Bian Ziqing , Yang Yujie , Cui Xinyue , Jeffreys Charles , Xu Xinjun , Li Wenhua , Liu Yuqiang , Heeney Martin , Bo Zhishan 
Published: June 2024

AbstractLayer‐by‐layer (LbL) deposition of active layers in organic solar cells (OSCs) offers immense potential for optimizing performance through precise tailoring of each layer. However, achieving high‐performance LbL OSCs with distinct solid additives in each layer remains challenging. In this study, we explore a novel approach that strategically incorporates different solid additives into specific layers of LbL devices. To this end, we introduce FeCl3 into the lower donor (D18) layer as a p‐type dopant to enhance hole concentration and mobility. Concurrently, we incorporate the wide‐band gap conjugated polymer poly(9,9‐di‐n‐octylfluorenyl‐2,7‐diyl) (PFO) into the upper acceptor (L8‐BO) layer to improve the morphology and prolong exciton lifetime. Unlike previous studies, our approach combines these two strategies to achieve higher and more balanced electron and hole mobility without affecting device open‐circuit voltage, while also suppressing charge recombination. Consequently, the power conversion efficiency (PCE) of the D18+FeCl3/L8‐BO device increases to 18.12 %, while the D18/L8‐BO+PFO device attains a PCE of 18.79 %. These values represent substantial improvements over the control device′s PCE of 17.59 %. Notably, when both FeCl3 and PFO are incorporated, the D18+FeCl3/L8‐BO+PFO device achieves a remarkable PCE of 19.17 %. In summary, our research results demonstrate the effectiveness of the layered solid additive strategy in improving OSC performance.
A Redox‐Active Phenothiazine‐based Pd2L4‐Type Coordination Cage and Its Isolable Crystalline Polyradical Cations
Authors: Huang Bin , Zhou Manfei , Hong Qiong‐Yan , Wu Meng‐Xiang , Zhao Xiao‐Li , Xu Lin , Gao En‐Qing , Yang Hai‐Bo , Shi Xueliang 
Published: June 2024

AbstractPolyradical cages are of great interest because they show very fascinating physical and chemical properties, but many challenges remain, especially for their synthesis and characterization. Herein, we present the synthesis of a polyradical cation cage 14⋅+ through post‐synthetic oxidation of a redox‐active phenothiazine‐based Pd2L4‐type coordination cage 1. It′s worth noting that 1 exhibits excellent reversible electrochemical and chemical redox activity due to the introduction of a bulky 3,5‐di‐tert‐butyl‐4‐methoxyphenyl substituent. The generation of 14⋅+ through reversible electrochemical oxidation is investigated by in situ UV/Vis‐NIR and EPR spectroelectrochemistry. Meanwhile, chemical oxidation of 1 can also produce 14⋅+ which can be reversibly reduced back to the original cage 1, and the process is monitored by EPR and NMR spectroscopies. Eventually, we succeed in the isolation and single crystal X‐ray diffraction analysis of 14⋅+, whose electronic structure and conformation are distinct to original 1. The magnetic susceptibility measurements indicate the predominantly antiferromagnetic interactions between the four phenothiazine radical cations in 14⋅+. We believe that our study including the facile synthesis methodology and in situ spectroelectrochemistry will shed some light on the synthesis and characterization of novel polyradical systems, opening more perspectives for developing functional supramolecular cages.
Growth and longevity of the endangered freshwater pearl mussel (Margaritifera margaritifera): Implications for conservation and management
Authors: Nykänen Sabrina , Taskinen Jouni , Hajisafarali Mahsa , Kuparinen Anna 
Published: June 2024

AbstractKey life‐history data, such as growth and age, are necessary to effectively manage and conserve threatened freshwater mussel species. Traditionally growth and age studies require large yet destructive sample sizes covering all age classes. Such methods pose a risk to populations of conservation concern, and therefore, alternative methods that need only limited sample sizes are necessitated to prevent further threats to such populations. We applied retrospective shell growth at age reconstructions to 98 critically endangered freshwater pearl mussel (FPM) individuals from 34 populations across Finland and Sweden, enabling the use of extremely small sample sizes (n = 1–6 per population). We compared the performance of six different growth models with the reconstructed size‐at‐age data across FPM juvenile (<20 years old) and adult life stages. The growth reconstruction model showed reasonable skill in reconstructing FPM growth patterns. The von Bertalanffy model showed to be a good general descriptor of growth for FPM, but it systematically underestimated the asymptotic size. The power law model was the most accurate in estimating juvenile growth (lowest deviances from the size‐at‐age data). FPM showed great variability in longevity (Amax = 54–254 years) and growth constant k (0.018–0.057 year−1). Our results show that reasonable estimates of growth can be attained even when sample sizes are extremely limited. The results can be further applied to gain knowledge on the population's age structure, size at maturation, and recovery potential. The methodology is applicable to other freshwater mussel species of conservation concern.
Valorization of spent coffee ground by mixing with various types of residual biomass for pellet production: evaluation of solid biofuel properties at different mixtures
Authors: Kougioumtzis Michael A. , Filippou Vasileios , Rontogianni Anatoli , Karampinis Emmanouil , Grammelis Panagiotis , Kakaras Emmanouel 
Published: June 2024

AbstractCoffee consumption is a daily habit for the majority of people worldwide, resulting in consistently large amounts of residue. Spent coffee ground (SCG) is the residue obtained during the brewing process. It represents an abundant source of energy biomass, or raw material for added value products but it is still largely unexploited. This residue may find several applications, such as in polymers/composites precursors, solid/liquid biofuels, biofertilizers, and so forth. The aim of the present paper was the pilot production of pellets by mixing SCG and other residual biomass feedstock. Coffee residues were mixed at different ratios (0, 10, 30, 50, 70, 90 wt%) together with: (i) forestry residues; (ii) sawmill residues; (iii) urban prunings; (iv) maize residues; (v) peach prunings; and (vi) miscanthus. Samples of each fuel mixture were analyzed at the Solid Fuels Laboratory of CPERI/CERTH (Chemical Process and Energy Resources Institute/Centre for Research and Technology Hellas) in Greece by applying established standards. The results of the analyses show that the mixing of biomass residues with coffee could result in competitive solid biofuels. More specifically, pellets with up to 10% coffee residues, mixed with sawmill residues, complied with the class A2 limits set by the international standard ISO 17225‐2 for wood pellets, and pellets with up to 30% coffee residues complied with the class B limits for wood pellets for commercial/residential applications. Urban prunings mixed with 10 wt% coffee residues are within the limits set for class B wood pellets.
Culture‐acquired genetic variation in human pluripotent stem cells: Twenty years on
Authors: Vales John P. , Barbaric Ivana 
Published: June 2024

AbstractGenetic changes arising in human pluripotent stem cells (hPSC) upon culture may bestow unwanted or detrimental phenotypes to cells, thus potentially impacting on the applications of hPSCs for clinical use and basic research. In the 20 years since the first report of culture‐acquired genetic aberrations in hPSCs, a characteristic spectrum of recurrent aberrations has emerged. The preponderance of such aberrations implies that they provide a selective growth advantage to hPSCs upon expansion. However, understanding the consequences of culture‐acquired variants for specific applications in cell therapy or research has been more elusive. The rapid progress of hPSC‐based therapies to clinics is galvanizing the field to address this uncertainty and provide definitive ways both for risk assessment of variants and reducing their prevalence in culture. Here, we aim to provide a timely update on almost 20 years of research on this fascinating, but a still unresolved and concerning, phenomenon.
Synthesis and characterization of Mo and W compounds for disulfide materials
Authors: Shin Sunyoung , Yeo Seongmin , Yeo So Jeong , Chung Taek‐Mo , Kim Chang Gyoun , Park Bo Keun 
Published: June 2024

AbstractMoS2 and WS2 are spotlighted as fungible materials of graphene that can be used in electronic devices owing to being semiconductors with indirect and direct band gaps. Precursors (Mo(NtBu)2(StBu)2 (1), W(NtBu)2(StBu)2 (2)) suitable for the deposition of these materials were synthesized and characterized. The molecular structures of 1 and 2 exhibit a tetrahedral geometry according to single‐crystal x‐ray crystallography. Thermogravimetric analyses of 1 and 2 showed two‐step weight loss. The residues from each step of 1 were MoS3 and MoS2, and these results were consistent with the subsequent deposition results of 1. We successfully established a PEALD‐MoS2 process using 1 and H2S plasma as the precursor and reactant, respectively, at relatively low temperatures of 150–300 °C without any post‐sulfurization process. A temperature‐dependent selective deposition of MoSx phases was observed with the growth of amorphous MoS3 films (150–200 °C), and crystalline MoS2 films (250–350 °C).
The relationships between the multidimensional planned behavior model, green brand awareness, green marketing activities, and purchase intention
Authors: Baltaci Duygu Çinar , Durmaz Yakup , Baltaci Furkan 
Published: June 2024

AbstractIntroductionThis study investigates the determinants impacting consumer purchasing behavior.MethodsUtilizing multidimensional planned behavior theory alongside measures of brand awareness and green brand awareness, this study examines the mediating role of multidimensional planned behavior theory. Empirical data were gathered through a survey conducted among Generation Z university students, yielding 638 responses. Analysis was performed on 590 valid responses.ResultsFindings indicate that green marketing initiatives and green brand awareness positively influence consumers’ purchase intentions. Subdimensions of the theory of planned behavior (TPB), namely, attitude, subjective norms, and perceived behavioral control, serve to strengthen these relationships and mediate the interaction process.ConclusionThis study contributes novel insights to the burgeoning field of green marketing literature, offering a structural model for firms and policymakers. It suggests that companies can effectively engage in informal consumer education through green marketing efforts, thereby influencing consumers’ purchasing decisions via planned behavior. Moreover, such activities foster an increase in consumers’ green brand awareness, providing companies with an opportunity to promote conscious consumer behavior. The study's utilization of the TPB is both timely and original, particularly in its alignment with the United Nations 2030 Sustainable Development Goals.
Diagnostic and prognostic significance of circulating secreted frizzled‐related protein 5 in colorectal cancer
Authors: Li Runhao , Liu Saifei , Yeo Kenny , Edwards Suzanne , Li Man Ying , Santos Ryan , Rad Sima Kianpour , Wu Fangmeinuo , Maddern Guy , Young Joanne , Tomita Yoko , Townsend Amanda , Fenix Kevin , Hauben Ehud , Price Timothy , Smith Eric 
Published: June 2024

AbstractBackgroundSecreted Frizzled‐Related Protein 5 (SFRP5) modulates Wnt signalling pathways, affecting diverse biological processes. We assessed the diagnostic and prognostic value of circulating SFRP5 (cSFRP5) in colorectal cancer (CRC)MethodsPlasma cSFRP5 concentrations were measured using enzyme‐linked immunosorbent assay (ELISA) in healthy donors (n = 133), individuals diagnosed with CRC (n = 449), colorectal polyps (n = 85), and medical conditions in other organs including cancer, inflammation, and benign states (n = 64).ResultsPatients with CRC, polyps, and other conditions showed higher cSFRP5 levels than healthy individuals (p < 0.0001). Receiver operating characteristic curves comparing healthy donors with medical conditions, polyps and CRC were 0.814 (p < 0.0001), 0.763 (p < 0.0001) and 0.762 (p < 0.0001), respectively. In CRC, cSFRP5 correlated with patient age (p < 0.0001), tumour stage (p < 0.0001), and histological differentiation (p = 0.0273). Levels, adjusted for patient age, sex, plasma age and collection institution, peaked in stage II versus I (p < 0.0001), III (p = 0.0002) and IV (p < 0.0001), were lowest in stage I versus III (p = 0.0002) and IV (p = 0.0413), with no difference between stage III and IV. Elevated cSFRP5 levels predicted longer overall survival in stages II‐III CRC (univariate: HR 1.82, 95% CI: 1.02–3.26, p = 0.024; multivariable: HR 2.34, 95% CI: 1.12–4.88, p = 0.015).ConclusionThis study confirms cSFRP5 levels are elevated in CRC compared to healthy control and reveals a correlation between elevated cSFRP5 and overall survival in stages II‐III disease.
Fertility preservation in male adolescents with cancer (2011–2020): A retrospective study in China
Authors: Liu Shasha , Wang Qiling , Zhu Wenbing , Zhang Zhou , Tang Wenhao , Sheng Huiqiang , Yang Jigao , Li Yushan , Liang Xiaowei , Meng Tianqing , Wang Zhiqiang , Lin Faxi , Dong Hao , He Xiaojin , Jiang Xianglong , Dai Shanjun , Zhang Aiping , Song Chunying , Liang Zuowen , Zhang Feng , Wang Xiaojun , Liang Peiyu , Gong Guihua , Huai Xiaohong , Wang Yanyun , Li Fuping , Zhang Xinzong 
Published: June 2024

AbstractBackgroundAccording to the studies, more than 80% of pediatric patients with cancer can achieve a survival rate greater than 5 years; however, long‐term chemotherapy and/or radiation therapy may seriously affect their reproductive ability. Fertility preservation in adolescents with cancer in China was initiated late, and related research is lacking. Analyze data to understand the current situation and implement measures to improve current practices.MethodsFrom 2011 to 2020, data on 275 male adolescents with cancer whose age ranged from 0 to 19 years old were collected from 16 human sperm banks for this retrospective study. Methods include comparing the basic situation of male adolescents with cancer, the distribution of cancer types, and semen quality to analyze the status of fertility preservation.ResultsThe mean age was 17.39 ± 1.46 years, with 13 cases (4.7%) aged 13–14 years and 262 cases (95.3%) aged 15–19 years. Basic diagnoses included leukemia (55 patients), lymphomas (76), germ cell and gonadal tumors (65), epithelial tumors (37), soft tissue sarcomas (14), osteosarcoma (7), brain tumors (5), and other cancers (16). There are differences in tumor types in different age stages and regions. The tumor type often affects semen quality, while age affects semen volume. Significant differences were found in sperm concentration and progressive motility before and after treatment (p < 0.001). Moreover, 90.5% of patients had sperm in their semen and sperm were frozen successfully in 244 patients (88.7%).ConclusionsThe aim of this study is to raise awareness of fertility preservation in male adolescents with cancer, to advocate for fertility preservation prior to gonadotoxic therapy or other procedures that may impair future fertility, and to improve the fertility status of future patients.