bluuebunny/crossref_metadata_2025_split huggingface dataset:
An anion exchange membrane sensor detects EGFR and its activity state in plasma CD63 extracellular vesicles from patients with glioblastoma
Authors: Maniya Nalin H. , Kumar Sonu , Franklin Jeffrey L. , Higginbotham James N. , Scott Andrew M. , Gan Hui K. , Coffey Robert J. , Senapati Satyajyoti , Chang Hsueh-Chia 
Published: June 2024

AbstractWe present a quantitative sandwich immunoassay for CD63 Extracellular Vesicles (EVs) and a constituent surface cargo, EGFR and its activity state, that provides a sensitive, selective, fluorophore-free and rapid alternative to current EV-based diagnostic methods. Our sensing design utilizes a charge-gating strategy, with a hydrophilic anion exchange membrane functionalized with capture antibodies and a charged silica nanoparticle reporter functionalized with detection antibodies. With sensitivity and robustness enhancement by the ion-depletion action of the membrane, this hydrophilic design with charged reporters minimizes interference from dispersed proteins, thus enabling direct plasma analysis without the need for EV isolation or sensor blocking. With a LOD of 30 EVs/μL and a high relative sensitivity of 0.01% for targeted proteomic subfractions, our assay enables accurate quantification of the EV marker, CD63, with colocalized EGFR by an operator/sample insensitive universal normalized calibration. We analysed untreated clinical samples of Glioblastoma to demonstrate this new platform. Notably, we target both total and “active” EGFR on EVs; with a monoclonal antibody mAb806 that recognizes a normally hidden epitope on overexpressed or mutant variant III EGFR. Analysis of samples yielded an area-under-the-curve (AUC) value of 0.99 and a low p-value of 0.000033, surpassing the performance of existing assays and markers.
Assessing flood risks in the Taquari-Antas Basin (Southeast Brazil) during the September 2023 extreme rainfall surge
Authors: Mantovani José , Alcântara Enner , Pampuch Luana A. , Praga Baião Cheila Flávia , Park Edward , Souza Custódio Maria , Gozzo Luiz Felippe , Bortolozo Cassiano Antonio 
Published: June 2024

AbstractThis analysis delves into precipitation dynamics in the Bacia Taquari Antas region, with a focus on September 2023. Employing a multi-scale approach encompassing monthly, daily, and subdaily analyses, the study unveils a consistent precipitation distribution throughout the year. September 2023’s anomaly, the second-highest in the dataset, prompts investigation into potential climatic variability. Notably, the daily analysis highlights September 4th, 2023, as significant, emphasizing the importance of historical context in evaluating weather event severity. Subdaily scrutiny of September 4th reveals intense, localized precipitation, raising concerns about hydrological impacts such as flash floods. Positive trends in Rx5day (maximum consecutive 5-day precipitation amount) and R25 (number of days in a year when precipitation exceeds 25 mm) indices indicate an increase in heavy precipitation events, aligning with broader climate change concerns. Shifting focus to flood extent and impact assessment in the Taquari-Antas Basin, a simulation model depicts the temporal evolution of the flood, reaching its peak on September 4th. Examination of affected areas, rainfall volumes, and impacts on census sectors, cities, and buildings furnishes critical data for disaster management. This study contributes to localized precipitation comprehension and broader issues of climate trends, flood risk evaluation, and urban vulnerability, providing a basis for informed decision-making and resilient planning strategies.
Scientific integrity and U.S. “Billion Dollar Disasters”
Authors: Pielke Roger 
Published: June 2024

AbstractFor more than two decades, the U.S. National Oceanic and Atmospheric Administration (NOAA) has published a count of weather-related disasters in the United States that it estimates have exceeded one billion dollars (inflation adjusted) in each calendar year starting in 1980. The dataset is widely cited and applied in research, assessment and invoked to justify policy in federal agencies, Congress and by the U.S. President. This paper performs an evaluation of the dataset under criteria of procedure and substance defined under NOAA’s Information Quality and Scientific Integrity policies. The evaluation finds that the “billion dollar disaster” dataset falls short of meeting these criteria. Thus, public claims promoted by NOAA associated with the dataset and its significance are flawed and at times misleading. Specifically, NOAA incorrectly claims that for some types of extreme weather, the dataset demonstrates detection and attribution of changes on climate timescales. Similarly flawed are NOAA’s claims that increasing annual counts of billion dollar disasters are in part a consequence of human caused climate change. NOAA’s claims to have achieved detection and attribution are not supported by any scientific analysis that it has performed. Given the importance and influence of the dataset in science and policy, NOAA should act quickly to address this scientific integrity shortfall.
miR-7 controls glutamatergic transmission and neuronal connectivity in a Cdr1as-dependent manner
Authors: Cerda-Jara Cledi A , Kim Seung Joon , Thomas Gwendolin , Farsi Zohreh , Zolotarov Grygoriy , Dube Giuliana , Deter Aylina , Bahry Ella , Georgii Elisabeth , Woehler Andrew , Piwecka Monika , Rajewsky Nikolaus 
Published: June 2024

AbstractThe circular RNA (circRNA) Cdr1as is conserved across mammals and highly expressed in neurons, where it directly interacts with microRNA miR-7. However, the biological function of this interaction is unknown. Here, using primary cortical murine neurons, we demonstrate that stimulating neurons by sustained depolarization rapidly induces two-fold transcriptional upregulation of Cdr1as and strong post-transcriptional stabilization of miR-7. Cdr1as loss causes doubling of glutamate release from stimulated synapses and increased frequency and duration of local neuronal bursts. Moreover, the periodicity of neuronal networks increases, and synchronicity is impaired. Strikingly, these effects are reverted by sustained expression of miR-7, which also clears Cdr1as molecules from neuronal projections. Consistently, without Cdr1as, transcriptomic changes caused by miR-7 overexpression are stronger (including miR-7-targets downregulation) and enriched in secretion/synaptic plasticity pathways. Altogether, our results suggest that in cortical neurons Cdr1as buffers miR-7 activity to control glutamatergic excitatory transmission and neuronal connectivity important for long-lasting synaptic adaptations.
Effect of exogenous γ-aminobutyric acid on physiological property, antioxidant activity, and cadmium uptake of quinoa seedlings under cadmium stress
Authors: Hao Xiao Hua , Liu Ke Xin , Zhang Meng Yuan 
Published: June 2024

Abstract
Increasing cadmium (Cd) pollution has negative effects on quinoa growth and production. Gamma-aminobutyric acid (GABA) confers plants with stress resistance to heavy metals; however, the mechanism remains unclear. We explored the effects of exogenous GABA on the physiological characteristics, antioxidant capacity, and Cd accumulation of quinoa seedlings under Cd stress using hydroponic experiments. Partial least-squares regression was used to identify key physical and chemical indices of seedlings affecting Cd accumulation. Compared with those of the CK group, exposure to 10 and 25 µmol·L−1 Cd significantly reduced the photosynthetic pigment contents, photosynthesis, and biomass accumulation of quinoa seedlings; resulted in shorter and thicker roots; decreased the length of the lateral roots; decreased the activities of superoxide dismutase (SOD) and peroxide (POD); and increased H2O2 and malondialdehyde (MDA) contents. Exogenous GABA reduced the Cd content in the stem/leaves and roots of quinoa seedlings under Cd stress by 13.22–21.63% and 7.92–28.32%, decreased Cd accumulation by 5.37–6.71% and 1.91–4.09%, decreased the H2O2 content by 38.21–47.46% and 45.81–55.73%, and decreased the MDA content by 37.65–48.12% and 29.87–32.51%, respectively. GABA addition increased the SOD and POD activities in the roots by 2.78–5.61% and 13.81–18.33%, respectively, under Cd stress. Thus, exogenous GABA can reduce the content and accumulation of Cd in quinoa seedlings by improving the photosynthetic characteristics and antioxidant enzyme activity and reducing the degree of lipid peroxidation in the cell membrane to alleviate the toxic effect of Cd stress on seedling growth.
Max–min fairness beamforming design for UAV‐enabled integrated sensing and communication
Authors: Li Peng , An Chunlian , Lei Mingdong 
Published: June 2024

AbstractThis paper investigates the design of transmit beamforming in an integrated sensing and communication system, where an unmanned aerial vehicle (UAV) equipped with a uniform linear array (ULA) transmits combined information‐carrying and dedicated sensing signals to perform multi‐user communication and simultaneously sense potential targets. First, the transmit beamforming design is formulated as a series of non‐convex optimisation problems, and then jointly design the information and sensing beamforming to maximise the minimum communication rate under an optimised UAV deployment location, subject to the sensing beampattern gain requirements and the limited transmit power of the UAV. However, due to the application of ULA on the UAV, the formulated problems are highly non‐convex and difficult to solve optimally. To address the aforementioned issue, an efficient algorithm is proposed to find suboptimal yet high‐quality solutions. This is achieved by adopting the successive convex approximation and semidefinite relaxation. The numerical results confirm the effectiveness of the proposed algorithm and demonstrate that the transmit beamforming design achieves a balance between communication and sensing performance.
The occurrence and mechanism of hysteresis between axial deformation and short‐circuit electromagnetic force during the vibration of power transformer windings
Authors: Jin Mingkai , Xu Weijie , Chen Weijiang , Zhang Qiaogen , Zhao Yi , Wen Tao 
Published: June 2024

AbstractMechanical stability is one of the core capabilities of power transformers. External short‐circuit accidents are the main cause of winding instability. International Electrotechnical Commission 60076‐5 standard recommends a method to calculate the short‐circuit strength of power transformer windings by comparing the stress within windings under the effect of the maximum electromagnetic force with the critical stress of the winding. This method assumes that the maximum deformation will be produced by the maximum electromagnetic force, which corresponds to the first peak of the waveform. However, owing to the interactions between disks during the vibration process, the maximum deformation may occur after the occurrence of the maximum electromagnetic force. The hysteresis phenomenon between disk deformation and electromagnetic force is studied. The definition of the hysteresis phenomenon during the vibration process is first demonstrated, and the mechanism of the hysteresis phenomenon is investigated. The vibration model is established. By decoupling analysis, the conditions for the formation of hysteresis are proposed, and the mechanism of the hysteresis phenomenon is validated by the experiment, which is conducted on a winding sample. In the deformation formula, the term that determines the time‐varying characteristic is found. The waveform‐determining term is the difference between the two cosine components, whose frequencies are the natural vibration frequency and the electromagnetic force frequency. When the two frequencies are close, the maximum deformation lags behind the maximum force, and the hysteresis phenomenon occurs.
Progressive prediction: Video anomaly detection via multi‐grained prediction
Authors: Zeng Xianlin , Jiang Yalong , Wang Yufeng , Fu Qiang , Ding Wenrui 
Published: June 2024

AbstractVideo Anomaly Detection (VAD) has been an active research field for several decades. However, most existing approaches merely extract a single type of feature from videos and define a single paradigm to indicate the extent of abnormalities. A coarse‐to‐fine three‐level prediction is built by integrating different levels of spatio‐temporal representations, better highlighting the difference between normal and abnormal behaviors. First, an object‐level trajectory prediction is proposed to model human historical position using a graph transformer network. Subsequently, skeleton‐level prediction is achieved by incorporating the positional information from the trajectory prediction. More importantly, based on the predicted skeleton, a skeleton‐guided pixel‐level region prediction is performed. A novel Skeleton Conditioned Generative Adversarial Network (SCGAN) is designed to explore the correlation between skeleton‐level and pixel‐level motion prediction. Benefiting from SCGAN, the prediction of human regions is contributed by both coarse‐grained and fine‐grained motion features. This three‐level prediction, namely Progressive Prediction Video Anomaly Detection (P3VAD), enlarges the prediction error on irregular motion patterns. Besides, a pixel‐level analysis method is proposed to achieve Background‐bias Elimination (BE) and denoise the predicted region. Experimental results validate the effectiveness of P3VAD on the four benchmark datasets (ShanghaiTech, CUHK Avenue, IITB‐Corridor, and ADOC).
Optimization of battery/ultra‐capacitor hybrid energy storage system for frequency response support in low‐inertia microgrid
Authors: Yegon Philemon , Singh Mukhtiar 
Published: June 2024

AbstractModern power system networks are under statutory obligations to integrate renewable energy sources (RES). The primary reason is to meet ever‐increasing energy demand and also to curtail environmental pollution by greenhouse gases. However, the higher penetration of RES has the tendency of reducing inertia of overall power system network. Consequently, frequency stability is affected and deviates beyond allowable permissible limits leading to power blackouts, load shedding, and even total system failure. To address the issues associated with reduced inertia, an optimal control of hybrid energy storage system (HESS) has been proposed. HESS is basically a combination of battery and ultracapacitor, where ultracapacitor addresses rapidly varying power component by mimicking inertia while the battery compensates long‐term power variations. Thus, the HESS is effectively controlled to compensate the loss of inertia by regulating its energy flow. For the purpose of improved efficiency and better power management of the HESS, an improvised particle swarm optimization (MPSO)‐based virtual inertia control design has been proposed. The proposed MPSO is utilized to tune the gains of bidirectional dc–dc converter in such a way that improves frequency nadir with faster response to transient disturbances. This proposed method is simulated in MATLAB and its merits are validated in real time using hardware in loop. On analysing of the results, it can be observed that frequency nadir is improved by 48.96% with significant reduction in rate of change of frequency in comparison to conventional particle swarm optimization.
Quantum computing challenges and solutions in software industry—A multivocal literature review
Authors: Salam Masaud , Ilyas Muhammad 
Published: June 2024

AbstractQuantum computing (QC) hinged upon the bedrock principles of quantum theory and holds promise for reforming a large number of industries. The researcher in this area aims to deliver a comprehensive understanding of the current state of the art and future trajectories of QC. The authors have discovered that most academic studies have concentrated upon dissecting specific aspects of QC. This discernment underscores the exigency of identifying challenges that might impede the seamless integration of QC within the software industry. Moreover, it becomes crucial to ascertain the panoply of solutions/practices required to overcome these barriers. A comprehensive multi‐vocal literature review was performed and culled a total of 49 academic papers for data extraction. A total of 13 challenges encountered by organisations were identified during the adoption of QC. Subsequently, these challenges were examined deeply and determined that five of them are the most critical, these are ‘Lack of quantum specific algorithms, dev and testing methodologies’, ‘Difficult compilation and debugging’, ‘Lack of development tools and technology’, ‘Lack of development guidelines & Quality Assurance Standards’ and ‘Lack of professional expert’, together founding over 30% of occurrences. These challenges from various perspectives were evaluated, including time frame, methodology, geographical region and publication platform. To address these barriers and implement the QC in software industry effectively, a total of 53 practices/solutions. This research aims to share valuable knowledge to simplify and amplify quantum application development.
Experimental investigation of BIPV/T application in winter season under Şanlıurfa's meteorological conditions
Authors: Demir Yusuf Can , Aktacir Mehmet Azmi 
Published: June 2024

AbstractConsidering that nearly 39% of the total CO2 emission released into the atmosphere today are thought to be due to the energy consumed by buildings, the importance of taking measures through buildings to combat global warming is evident. Therefore, the concept of nearly zero‐energy buildings (NZEB) is come to the forefront. Building integrated photovoltaic thermal (BIPV/T) systems are used to enable buildings to generate their own energy. However, buildings have limited facade and roof areas required for BIPV/T systems. Therefore, in this study, various configurations of bifacial (double‐sided) and monofacial (single‐sided) panels were compared to investigate ways to enhance the efficiency of BIPV/T systems. Different air flow velocities and varying air gap distances were tested for both panel types. By placing a reflective surface on the wall behind the bifacial panel, the electrical efficiency of the bifacial panel was increased and proven through PVsyst analysis. Both panels provided maximum heat efficiency at the shortest air gap distance under high air flow conditions. In addition, it was shown in both the experimental setup and Comsol CFD analysis that it provides significant benefit in the thermal energy load of the building when heating the interior environment in winter. In terms of electrical power production surplus, the bifacial panel outperformed the monofacial panel in all configurations, with a minimum advantage of 8.33% and a maximum of 12.73%. Additionally, the maximum electrical efficiency was obtained from the bifacial panel in configurations with the longest air gap distance. Using the bifacial panel in the BIPV/T system with the shortest air gap distance during the heating season and the longest air gap distance during other seasons can provide the highest efficiency for the building throughout the year.
Maternal Cardiac Disease and Perinatal Outcomes in a Single Tertiary
Care Center
Authors: Ezveci Huriye , Doğru Şükran , Akkuş Fatih , Metin Ülfet Sena , Gezginc Kazim 
Published: June 2024

Abstract
Objective This study aims to compare the perinatal outcomes of pregnant
women with heart disease and a healthy pregnant control group, as well as the
maternal and newborn outcomes of pregnant women with congenital heart disease
and acquired heart disease.
Material method Pregnant women with heart disease and healthy control
pregnant women were included in this retrospective study. Sociodemographic data
of all patients included in the study were obtained from electronic records.
Perinatal outcomes of all patients were compared.
Results A total of 258 pregnant women were included in the study. While
129 pregnant women were diagnosed with heart disease, 129 patients were low-risk
pregnant women. Preeclampsia (p=0.004) and cesarean section (p=0.01) rates were
higher in pregnant women with heart disease compared to healthy pregnant women.
Compared with healthy pregnant women, pregnant women with heart disease had a
lower birth weight (p=0.003), a higher fetal growth restriction (FGR) rate
(p=0.036), lower birth percentiles (p=0.002), a lower 5-minute APGAR (p=0.0001),
a higher neonatal intensive care unit (NICU) admission rate (p=0.001), and a
longer NICU stay rate (p=0.001). The mean gestational age at birth of pregnant
women with congenital heart disease was higher than that of those with acquired
heart disease (p=0.017).
Conclusion It was observed that all maternal heart diseases were
associated with adverse perinatal outcomes compared to healthy pregnant women.
In this series, perinatal adverse outcomes of pregnant women with congenital and
acquired heart disease did not differ. Keywords: acquired heart disease,
congenital heart disease, pregnancy
A Lifeboat for Failed Nasal Reconstructions: The Supraclavicular–Submental Sandwich Flap
Authors: Vaena Michel L.H.T. , Sicalo Kevin , Alessio Caterina Goulart , Bastos Eduardo Pantoja 
Published: June 2024

AbstractMany failures in total or subtotal nasal reconstruction result from an underestimation of the amount of skin required for an adequate result, especially for sufficient lining. Such planning errors usually lead to poor results, with exposure of structural grafts, infection, scar retraction, airway obstruction, and finally loss of projection and shape of the reconstructed nose. Reconstruction options for cases in which previous attempts have failed are always limited, as well as in cases of trauma or burns affecting the soft tissues of the forehead and face. In such complex situations, one may employ free flaps or tissue expansion, but such resources may not be always available. We describe a technique indicated for salvage surgeries in patients whose previous nasal reconstructions have failed, allowing a generous amount of tissue transfer for the nasal region. The technique combines the use of supraclavicular and submental flaps, with simple execution, not requiring microsurgical skills or devices such as tissue expanders. Done in three stages, the described technique provides enough skin for a total nasal reconstruction. The final result is obtained after subsequent refinements, and the total number of procedures is equivalent to when more sophisticated techniques are employed, such as tissue expansion or microsurgery.