bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introducing a new parameter for quality control of proteome profiles: Consideration of commonly expressed proteins
Authors: Slany Astrid , Haudek Verena J. , Gundacker Nina C. , Griss Johannes , Mohr Thomas , Wimmer Helge , Eisenbauer Maria , Elbling Leonilla , Gerner Christopher 
Published: April 2009

AbstractInterpretation of proteome profiling experiments largely relies on comparative analyses. False‐positive identifications may cause fatal misinterpretation of data. On the other hand, proteome analysis may also suffer from false negatives, when proteins that are actually present are not detected. This circumstance may be as fatal as false‐positive identifications and was hardly considered until now. Appropriate positive controls would facilitate quality assessment of proteome profiling experiments. Based on cell biology knowledge, our aim was to generate a list of commonly expressed proteins, which may serve as positive control. Following a pragmatic experimental strategy, we compared the cytoplasmic fractions of four largely differing kinds of cells, which were human DCs, endothelial cells, fibroblasts and keratinocytes. Proteome profiling was performed by 2D‐PAGE in addition to shotgun analysis. By shotgun analysis, 665 proteins were identified, which occurred in each of the four cells types; 360 proteins of those were also detectable in the corresponding 2‐D gels. We consider these proteins as common proteins. All shotgun analysis data, including mass fragmentation spectra of the corresponding peptides, are accessible via the proteomics identification database (http://www.ebi.ac.uk/pride). As expected, most of the common proteins could be clearly assigned to at least one of the following functional categories: chaperones, cytoskeleton, energy metabolism, redox regulation, nucleic acid processing, protein turnover, membrane transport, protein synthesis and signaling. We suggest that the present data may prove helpful for data assessment, quality control and interpretation of a large variety of experiments based on proteome profiling.
Omic analyses unravels global molecular changes in the brain and liver of a rat model for chronic Sake (Japanese alcoholic beverage) intake
Authors: Masuo Yoshinori , Imai Tsunehiko , Shibato Junko , Hirano Misato , Jones Oliver A. H. , Maguire Mahon L. , Satoh Kouji , Kikuchi Shoshi , Rakwal Randeep 
Published: April 2009

AbstractThe effects of chronic administration of Sake (Japanese alcoholic beverage, Nihonshu) on brain and liver of female F334 (Fisher) rats were surveyedviaglobal omic analyses using DNA microarray, 2‐DE, and proton nuclear magnetic resonance. Rats weaned at 4 wk of age were given free access to Sake (15% alcohol), instead of water. At 13 months of age, and 24 h after withdrawal of Sake supply, rats were sacrificed, and the whole brain and liver tissues dissected for analyses. In general, molecular changes in brain were found to be less than those in liver. Transcriptomics data revealed 36 and 9, and 80 and 62 up‐ and down‐regulated genes, in the brain and liver, respectively, with binding and catalytic activity gene categories the most prominently changed. Results suggested Sake‐induced fragility of brain and liver toxicity/damage, though no significant abnormalities in growth were seen. At protein level, a striking decrease was found in the expression of NADH dehydrogenase (ubiquinone) Fe‐S protein 1 in brain, suggesting attenuation of mitochondrial metabolism. In liver, results again suggested an attenuation of mitochondrial function and, in addition, glycoproteins with unknown function were induced at protein and gene levels, suggesting possible changes in glycoprotein binding in that organ. Metabolomic analysis of brain revealed significant increases in valine, arginine/ornithine, alanine, glutamine, and choline with decreases in isoleucine,N‐acetyl aspartate, taurine, glutamate, and gamma aminobutyric acid. Our results provide a detailed inventory of molecular components of both brain and liver after Sake intake, and may help to better understand effects of chronic Sake drinking.
Seismic reliability of V‐braced frames: Influence of design methodologies
Authors: Longo Alessandra , Montuori Rosario , Piluso Vincenzo 
Published: April 2009

AbstractAccording to the most modern trend, performance‐based seismic design is aimed at the evaluation of the seismic structural reliability defined as the mean annual frequency (MAF) of exceeding a threshold level of damage, i.e. a limit state. The methodology for the evaluation of the MAF of exceeding a limit state is herein applied with reference to concentrically ‘V’‐braced steel frames designed according to different criteria. In particular, two design approaches are examined. The first approach corresponds to the provisions suggested by Eurocode 8 (prEN 1998—Eurocode 8: design of structures for earthquake resistance. Part 1: general rules, seismic actions and rules for buildings), while the second approach is based on a rigorous application of capacity design criteria aiming at the control of the failure mode (J. Earthquake Eng. 2008; 12:1246–1266; J. Earthquake Eng. 2008; 12:728–759). The aim of the presented work is to focus on the seismic reliability obtained through these design methodologies. The probabilistic performance evaluation is based on an appropriate combination of probabilistic seismic hazard analysis, probabilistic seismic demand analysis (PSDA) and probabilistic seismic capacity analysis. Regarding PSDA, nonlinear dynamic analyses have been carried out in order to obtain the parameters describing the probability distribution laws of demand, conditioned to given values of the earthquake intensity measure. Copyright © 2009 John Wiley & Sons, Ltd.
Extreme weight change behaviours: Are overweight and normal weight adolescents different, and does this vary over time?
Authors: McCabe Marita P. , Ricciardelli Lina A. 
Published: April 2009

AbstractThis study examined the nature of extreme weight loss behaviours among overweight and normal weight adolescents. Body mass index (BMI), body dissatisfaction, body importance, pubertal timing, negative affect, bulimic symptoms, food supplements and exercise dependence were evaluated at Time 1 and 16 months later at Time 2 among 788 adolescents. There were a large number of differences in the strategies adopted by overweight adolescents, and these remained relatively stable over time. In addition, girls engaged in more bulimic symptoms than boys; particularly overweight girls. Negative affect was also a major predictor of health risk behaviours for overweight adolescent boys and girls. Implications of these findings for the treatment of extreme weight loss behaviours among overweight adolescents are discussed. Copyright © 2009 John Wiley & Sons, Ltd and Eating Disorders Association.
Risk and protective factors for disturbed eating in adolescent girls – aspects of perfectionism and attitudes to eating and weight
Authors: Gustafsson Sanna Aila , Edlund Birgitta , Kjellin Lars , Norring Claes 
Published: April 2009

AbstractThe aim of this study was to longitudinally examine the role of personal standards, self‐evaluation, perceived benefits of thinness and attitudes to eating and weight in the development of healthy versus disturbed eating in adolescent girls. In a longitudinal study, girls who participated in two assessments, four to five years apart, were divided into three groups according to the attitudes to eating that they manifested at the second evaluation: those with disturbed eating patterns (DE‐group, n = 49), those with intermediate concerns about eating (IE‐group, n = 260) and those with healthy eating attitudes (HE‐group, n = 120). Variables concerning attitudes to eating and weight and physical self‐evaluation emerged as risk factors, whereas personal standards or self‐evaluation in general did not. Protective factors were a low BMI, healthy eating attitudes, an accepting attitude towards body size and a positive self‐evaluation, particularly with regard to physical and psychological characteristics. The results of this study contribute to the understanding of early risk and protective factors for eating disturbances in girls. Copyright © 2009 John Wiley & Sons, Ltd and Eating Disorders Association.
An approach to sub‐grouping the eating disorder population: Adding attachment and coping style
Authors: Turner Hannah , Bryant‐Waugh Rachel , Peveler Robert 
Published: April 2009

AbstractObjectiveTo investigate whether clinically meaningful sub‐groups of patients can be identified by clustering eating disorder features, attachment and coping styles.Method165 patients completed the Eating Disorder Examination (EDE), Attachment Style Questionnaire (ASQ) and Utrecht Coping List (UCL). Cluster analysis was used to identify sub‐groups across the sample.ResultsFour clusters were identified. Cluster one had low levels of eating disorder behaviours and the most severe attachment and coping difficulties. Cluster two had high levels of dietary restriction and exercise, and a fearful/avoidant attachment style. Cluster three had high levels of binge eating and vomiting, and few attachment and coping difficulties. Cluster four had low levels of eating disorder features and positive attachment and coping styles.ConclusionsClustering participants on the basis of eating disorder features, attachment and coping yields four sub‐groups appearing to have clinical face validity. Copyright © 2009 John Wiley & Sons, Ltd and Eating Disorders Association.
Erratum: John F. Morgan (2008) The invisible man: A self‐help guide for men with eating disorders, compulsive exercise and bigorexia, routledge: London, UK, (paperback), pp. 172, ISBN 978‐1‐58391‐150‐1
Authors: Waine Joanne 
Published: April 2009

AbstractThe above paper (DOI: 10.1002/erv.905) was published online on 24 February 2009 in Wiley Interscience (www.interscience.com), and in print in European Eating Disorders Review 17 (2): 162–163. The following error was subsequently identified.The author of this book review was wrongly given as Frances Connan. The author was in fact Joanne Waine.The Publisher accepts full responsibility for this error and would like to apologise for any confusion caused.
Optimal location of unified power flow controller for congestion management
Authors: Chong B. , Zhang X. P. , Godfrey K. R. , Yao L. , Bazargan M. 
Published: April 2009

AbstractIn deregulated environments, electricity companies are likely to experience an increase in the number of daily market transactions. High penetration of renewable energy generation is likely to bring further uncertainty of network management in terms of power flows and voltages where the systems are being operated towards their limits. Subsequently the stressed systems would result in congestion in transmission networks. Therefore, effective means for congestion management of transmission networks will become increasingly important, particularly for transmission system operators (TSOs). The benefits of using flexible AC transmission system (FACTS) controllers on transmission networks for static and dynamic control are well recognized. In this paper, a sensitivity based three‐step optimization method, capable of determining the congestion cost, optimal location and rating of a unified power flow controller (UPFC) is presented. A bilateral electricity market model is assumed and the proposed method is illustrated using the IEEE 30 bus system. Results show high congestion cost reductions, which reinforces the UPFC as a viable solution. In addition, it is shown that the sensitivity based method is efficient at identifying the vicinity of the optimal location for installation, as the number of required simulations is kept to a minimum. Copyright © 2009 John Wiley & Sons, Ltd.
Heterogeneity of Kir4.1 channel expression in glia revealed by mouse transgenesis
Authors: Tang Xiaofang , Taniguchi Kenichiro , Kofuji Paulo 
Published: April 2009

AbstractThe weakly inwardly rectifying K+channel Kir4.1 is found in many glial cells including astrocytes. However, questions remain regarding the relative contribution of Kir4.1 to the resting K+conductance of mature astrocytes in situ. We employed a bacterial artificial chromosome transgenic approach in mice to visualize Kir4.1 expression in vivo. These mice (Kir4.1‐EGFP) express enhanced green fluorescent protein (EGFP) under the transcriptional control of the Kir4.1 promoter. The brains of adult Kir4.1‐EGFP transgenic mice showed co‐expression of EGFP and Kir4.1 in astrocytes. In addition, weaker expression of EGFP was detected in NG2+ glial cells when compared with EGFP expression in GFAP+ glial cells. Whole‐cell voltage clamp recordings of EGFP+ glial cells in the CA1 area of the adult mouse hippocampus indicated astrocytes displaying properties consistent with both the “passive” and “complex” subpopulations. EGFP+ cells with bright fluorescence had the linear current–voltage (I–V) relationships and extensive gap junctional coupling characteristic of passive astrocytes. However, EGFP+ glia with weaker fluorescence displayed properties associated with complex astrocytes including nonlinearI–Vrelationships and lack of intercellular gap junctional coupling. Pharmacological blockade of inward currents implied that Kir4.1 channels constitute the dominant resting K+conductance in both glial cell types and are more highly expressed in passive astrocytes. These results suggest differential expression of Kir4.1 in glia and that this channel likely underlies the resting K+conductance in passive and complex astrocytes. © 2009 Wiley‐Liss, Inc.
Mental capacity to consent to treatment and admission decisions in older adult psychiatric inpatients
Authors: Maxmin Kate , Cooper Claudia , Potter Laurence , Livingston Gill 
Published: April 2009

AbstractObjectivesThere is little information about older adult psychiatric inpatients' capacity to consent to clinical decisions. In younger adults, lack of capacity is associated with poor insight and psychosis rather than cognitive impairment. We assessed the prevalence and predictors of mental capacity to make treatment and admission decisions in older psychiatric inpatients, and asked their views about who should make these decisions.MethodsWe interviewed 99 participants using the MacArthur Competence Assessment Tool for Treatment (MacCAT‐T) in three geographical locations.ResultsFifty‐two (52.5%) participants had capacity for admission and 38 (38.4%) for treatment decisions. Capacity was associated with not having dementia, and higher levels of insight and cognition. Those with depression were more likely to have capacity than those with psychosis. 75% of patients without capacity for admission were not detained legally.ConclusionsPatients can have capacity to make decisions in one area but not in others. Many people are admitted and treated in a way that is contrary to the human rights legislation. The new Deprivation of Liberty Safeguards in England and Wales are likely to apply to a significant proportion of older inpatients. Most people wanted doctors to make treatment and admission decisions and very few wanted their family to make decisions on their behalf. Copyright © 2009 John Wiley & Sons, Ltd.
At‐risk alcohol drinking in primary care patients aged 75 years and older
Authors: Weyerer Siegfried , Schäufele Martina , Eifflaender‐Gorfer Sandra , Köhler Leonore , Maier Wolfgang , Haller Franziska , Cvetanovska‐Pllashiniku Gabriela , Pentzek Michael , Fuchs Angela , van den Bussche Hendrik , Zimmermann Thomas , Eisele Marion , Bickel Horst , Mösch Edelgard , Wiese Birgitt , Angermeyer Matthias C. , Riedel‐Heller Steffi G. ,   for the German AgeCoDe Study group (German Study on Ageing, Cognition, Dementia in Primary Care Patients).
Published: April 2009

AbstractBackgroundLittle is known about the prevalence and risk factors of alcohol problems among older people (especially those aged 75 years and more). The aims of this study were to report alcohol consumption patterns and to determine their association with socio‐demographic variables and health characteristics.Method3224 non‐demented subjects aged 75 and over and attending general practitioners (GPs) (n = 138) in an urban area of Germany were studied by structured clinical interviews including detailed assessment of alcohol consumption patterns distinguishing between abstainers, moderate drinkers and at‐risk drinkers (>20 g of alcohol for women and >30 g of alcohol for men).ResultsA high proportion (50.1%) of the sample were abstainers, 43.4% were moderate drinkers. The prevalence of at‐risk alcohol consumption was 6.5% (95% CI 5.6–7.4). Rates were significantly higher for men (12.1%; 95% CI 10.2–14.0) compared to women (3.6%; 95% CI 2.8–4.4). After full adjustment for confounding variables we found that compared to moderate drinking abstaining from alcohol was significantly associated with female gender, lower education, and mobility impairment. Compared to moderate drinking at‐risk drinking was significantly higher among men, individuals with a liver disease, and current smokers.ConclusionsMultivariate analysis revealed that, apart from liver disease, at‐risk drinking in a non‐demented population aged 75 and over was associated with relatively good physical and mental health. Nevertheless, public prevention measures should focus on at‐risk drinkers to make them aware of potential risks of high alcohol consumption in old age. Copyright © 2009 John Wiley & Sons, Ltd.
International survey on willingness‐to‐pay (WTP) for one additional QALY gained: what is the threshold of cost effectiveness?
Authors: Shiroiwa Takeru , Sung Yoon‐Kyoung , Fukuda Takashi , Lang Hui‐Chu , Bae Sang‐Cheol , Tsutani Kiichiro 
Published: April 2009

AbstractAlthough the threshold of cost effectiveness of medical interventions is thought to be £20 000–£30 000 in the UK, and $50 000–$100 000 in the US, it is well known that these values are unjustified, due to lack of explicit scientific evidence. We measured willingness‐to‐pay (WTP) for one additional quality‐adjusted life‐year gained to determine the threshold of the incremental cost‐effectiveness ratio. Our study used the Internet to compare WTP for the additional year of survival in a perfect status of health in Japan, the Republic of Korea (ROK), Taiwan, Australia, the UK, and the US. The research utilized a double‐bound dichotomous choice, and analysis by the nonparametric Turnbull method. WTP values were JPY 5 million (Japan), KWN 68 million (ROK), NT$ 2.1 million (Taiwan), £23 000 (UK), AU$ 64 000 (Australia), and US$ 62 000 (US). The discount rates of outcome were estimated at 6.8% (Japan), 3.7% (ROK), 1.6% (Taiwan), 2.8% (UK), 1.9% (Australia), and 3.2% (US). Based on the current study, we suggest new classification of cost‐effectiveness plane and methodology for decision making. Copyright © 2009 John Wiley & Sons, Ltd.
Dynamic versus static models in cost‐effectiveness analyses of anti‐viral drug therapy to mitigate an influenza pandemic
Authors: Lugnér Anna K. , Mylius Sido D. , Wallinga Jacco 
Published: April 2009

AbstractConventional (static) models used in health economics implicitly assume that the probability of disease exposure is constant over time and unaffected by interventions. For transmissible infectious diseases this is not realistic and another class of models is required, so‐called dynamic models. This study aims to examine the differences between one dynamic and one static model, estimating the effects of therapeutic treatment with antiviral (AV) drugs during an influenza pandemic in the Netherlands. Specifically, we focus on the sensitivity of the cost‐effectiveness ratios to model choice, to the assumed drug coverage, and to the value of several epidemiological factors. Therapeutic use of AV‐drugs is cost‐effective compared with non‐intervention, irrespective of which model approach is chosen. The findings further show that: (1) the cost‐effectiveness ratio according to the static model is insensitive to the size of a pandemic, whereas the ratio according to the dynamic model increases with the size of a pandemic; (2) according to the dynamic model, the cost per infection and the life‐years gained per treatment are not constant but depend on the proportion of cases that are treated; and (3) the age‐specific clinical attack rates affect the sensitivity of cost‐effectiveness ratio to model choice. Copyright © 2009 John Wiley & Sons, Ltd.
Systematic reviews of economic evaluations: utility or futility?
Authors: Anderson Rob 
Published: April 2009

AbstractSystematic reviews of studies of effectiveness are the centrepiece of evidence‐based medicine and policy making. Increasingly, systematic reviews of economic evaluations are also an expected input into much evidence‐based policy making, with some health economists even calling for ‘an economics approach to systematic review’.This paper questions the value of conducting systematic reviews of economic evaluations to inform decision making in health care. It argues that the value of systematic reviews of economic evaluations is usually undermined by three things. Firstly, compared with effectiveness studies, there is a much wider range of factors that limit the generalisability of cost–effectiveness results, over time and between health systems and service settings, including the context‐dependency of resource use and opportunity costs, and different decision contexts and budget constraints. Secondly, because economic evaluations are more explicitly intended to be decision‐informing, the requirements for generalisability take primacy, and considerations of internal validity become more secondary. Thirdly, since one of the two main forms of economic evaluation – decision analytic modelling – is itself a well‐developed method of evidence synthesis, in most cases the need for a comprehensive systematic review of previous economic evaluations of a particular health technology or policy choice is unwarranted.I conclude that apparent ‘meta‐analytic expectations’ for clear and widely applicable cost–effectiveness conclusions from systematic reviews of economic evaluations are optimistic and generally futile. For more useful insights and knowledge from previous economic studies in evidence‐based policy making, a more limited range of reasons for conducting systematic reviews of health economic studies is proposed. Copyright © 2009 John Wiley & Sons, Ltd.
Regime switching in stock index and futures markets: a note on the NIKKEI evidence
Authors: Kanas Angelos 
Published: April 2009

AbstractUsing a time‐varying regime‐switching vector error correction approach, we find strong evidence that the NIKKEI stock index cash and futures prices are jointly characterized by regime switching, which is time‐varying and dependent upon the basis, the interest rate, the volatility of the cash index, and the US futures market. Copyright © 2009 John Wiley & Sons, Ltd.