bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bi‐modal OnPLS
Authors: Löfstedt Tommy , Eriksson Lennart , Wormbs Gunilla , Trygg Johan 
Published: April 2012

This paper presents an extension to the recently published OnPLS data analysis method. Bi‐modal OnPLS allows for arbitrary block relationships in both columns and rows and is able to extract orthogonal variation in both columns and rows without bias towards any particular direction or matrix: the method is fully symmetric with regard to both rows and columns.Bi‐modal OnPLS extracts a minimal number of globally predictive score vectors that exhibit maximal covariance and correlation in the column space and a corresponding set of predictive loading vectors that exhibit maximal correlation in the row space. The method also extracts orthogonal variation (i.e. variation that is not related to all other matrices) in both columns and rows. The method was applied to two synthetic datasets and one real data set regarding sensory information and consumer likings of dairy products. It was shown that Bi‐modal OnPLS greatly improves the intercorrelations between both loadings and scores while still finding the correct variation. This facilitates interpretation of the predictive components and makes it possible to study the orthogonal variation in the data. Copyright © 2012 John Wiley & Sons, Ltd.
Structures and Dynamic Solution Behavior of Cationic, Two‐Coordinate Gold(I)–π‐Allene Complexes
Authors: Brown Timothy J. , Sugie Atsushi , Leed Marina G. D. , Widenhoefer Ross A. 
Published: April 2012

AbstractA family of seven cationic gold complexes that contain both an alkyl substituted π‐allene ligand and an electron‐rich, sterically hindered supporting ligand was isolated in >90 % yield and characterized by spectroscopy and, in three cases, by X‐ray crystallography. Solution‐phase and solid‐state analysis of these complexes established preferential binding of gold to the less substituted CC bond of the allene and to the allene π face trans to the substituent on the uncomplexed allenyl CC bond. Kinetic analysis of intermolecular allene exchange established two‐term rate laws of the form rate=k1[complex]+k2[complex][allene] consistent with allene‐independent and allene‐dependent exchange pathways with energy barriers of ΔG≠1=17.4–18.8 and ΔG≠2=15.2–17.6 kcal mol−1, respectively. Variable temperature (VT) NMR analysis revealed fluxional behavior consistent with facile (ΔG≠=8.9–11.4 kcal mol−1) intramolecular exchange of the allene π faces through η1‐allene transition states and/or intermediates that retain a staggered arrangement of the allene substituents. VT NMR/spin saturation transfer analysis of [{P(tBu)2o‐binaphthyl}Au(η2‐4,5‐nonadiene) ]+SbF6− (5), which contains elements of chirality in both the phosphine and allene ligands, revealed no epimerization of the allene ligand below the threshold for intermolecular allene exchange (ΔG≠298K=17.4 kcal mol−1), which ruled out the participation of a η1‐allylic cation species in the low‐energy π‐face exchange process for this complex.
Orthoamides and Iminium Salts LXXII: N,N,N′,N′,N′′,N′′,N′′′,N′′′‐Octamethyl‐(but‐2‐yne)‐bis(amidinium) Tetrafluoroborate: The First Bis‐amidinium Salt of Acetylenedicarboxyclic Acid. A New Superelectrophile?
Authors: Drandarov Konstantin , Tiritiris Ioannis , Wassiljew Olga , Siehl Hans‐Ullrich , Kantlehner Willi 
Published: April 2012

AbstractA method for the preparation of the first acetylenedicarboxamidinium salt from a bis‐orthoamide derivative of acetylenedicarboxyclic acid has been established. The salt reacted with cyclopentadiene and furan at room temperature to give bicyclic [4+2]‐cycloaddition products. The solid compounds were characterized by solution NMR spectroscopy and by single‐crystal X‐ray diffraction. Quantum‐chemical calculations of the isolated N,N,N′,N′,N′′,N′′,N′′′,N′′′‐octamethyl‐acetylene‐bis(carboxamidinium) ion showed very good agreement with the spectroscopic and diffraction data.
ChemInform Abstract: The Synthesis of a New Class of Chiral Pincer Ligands and Their Applications in Enantioselective Catalytic Fluorinations and the Nozaki—Hiyama—Kishi Reaction.
Authors: Deng Qing‐Hai , Wadepohl Hubert , Gade Lutz H. 
Published: April 2012

AbstractA new class of chiral tridentate N‐donor pincer ligands, bis(oxazolinylmethylene)isoindolines (boxmi) is prepared and shown to catalyze the title reactions with up to <99% e.e.
ChemInform Abstract: Gold‐Catalyzed Formal [3 + 3] and [4 + 2] Cycloaddition Reactions of Nitrosobenzenes with Alkenylgold Carbenoids.
Authors: Pagar Vinayak Vishnu , Jadhav Appaso Mahadev , Liu Rai‐Shung 
Published: April 2012

AbstractQuinoline oxides (III) and (V) are obtained in satisfactory yields from gold‐catalyzed [3 + 3]‐cycloadditions between nitrosobenzenes and alkenyldiazo esters (I).
ChemInform Abstract: Palladium Nanoparticles Generated from Allylpalladium Chloride in situ: A Simple and Highly Efficient Catalytic System for Mizoroki—Heck Reactions.
Authors: Wang Wei , Yang Qin , Zhou Rong , Fu Hai‐Yan , Li Rui‐Xiang , Chen Hua , Li Xian‐Jun 
Published: April 2012

AbstractMizoroki—Heck reaction of aryl bromides (II) and (VII) with terminal olefins (I) and (VI) proceeds efficiently in the presence of Pd nanoparticles generated from Pd2Cl2(allyl)2.
ChemInform Abstract: Regioselective Base‐Free Intermolecular Aminohydroxylations of Hindered and Functionalized Alkenes.
Authors: Ma Zhiwei , Naylor Bradley C. , Loertscher Brad M. , Hafen Danny D. , Li Jasmine M. , Castle Steven L. 
Published: April 2012

AbstractThe resulting amino alcohol (IIId) is a useful precursor of dehydroamino acid esters such as (V).
ChemInform Abstract: Copper‐Catalyzed Oxidative Alkynylation of Diaryl Imines with Terminal Alkynes: A Facile Synthesis of Ynimines.
Authors: Laouiti Anouar , Rammah Mohamed M. , Rammah Mohamed B. , Marrot Jerome , Couty Francois , Evano Gwilherm 
Published: April 2012

AbstractIn all reactions carried out under conditions A), formation of azine by‐products is observed.
ChemInform Abstract: Rhodium(III)‐Catalyzed Intermolecular Direct Amination of Aromatic C—H Bonds with N‐Chloroamines.
Authors: Ng Ka‐Ho , Zhou Zhongyuan , Yu Wing‐Yiu 
Published: April 2012

AbstractThe one‐pot two‐step process without isolation of the chloroamines succeeds with comparable yields, cf.(XIX).
ChemInform Abstract: Microwave‐Enhanced Catalyst‐Free Aminolysis of Epoxides with Anilines in Aqueous Phase: Efficient Synthesis of β‐Amino Secondary Alcohols.
Authors: Du Zhengyin , Zhang Wenwen , Zhang Yuanmin , Wei Xiaohong 
Published: April 2012

AbstractA fast, efficient, highly regioselective, chemoselective, catalyst‐free, and environmentally benign method for the aminolysis of epichlorohydrin and styrene oxide with various aromatic amines leading to β‐amino secondary alcohols (III) is developed.
ChemInform Abstract: Oxidation of Benzylic Azides Catalyzed by Iron(III) Chloride with Hydrogen Peroxide as Oxidant.
Authors: Zhang Hong‐Ping , Dai You‐Zhi , Tao Li‐Ming 
Published: April 2012

AbstractA simple and general method for the selective oxidation of a wide range of benzylic azides to corresponding aldehydes using inexpensive and environmentally benign iron(III) chloride as catalyst and aq.
ChemInform Abstract: Highly Enantioselective Lewis Base Organocatalyzed Hydrosilylation of γ‐Imino Esters.
Authors: Xue Zhou‐Yang , Liu Li‐Xin , Jiang Yan , Yuan Wei‐Cheng , Zhang Xiao‐Mei 
Published: April 2012

AbstractVarious optically active γ‐amino esters are obtained by use of chiral picolinamide catalyst PPY under optimized conditions.
ChemInform Abstract: Enantio‐ and Diastereoselective Organocatalytic α‐Alkylation of Aldehydes with 3‐Substituted 2‐(Bromomethyl)acrylates.
Authors: Jimenez Jacqueline , Landa Aitor , Lizarraga Aitziber , Maestro Miguel , Mielgo Antonia , Oiarbide Mikel , Velilla Irene , Palomo Claudio 
Published: April 2012

AbstractA simple and highly stereoselective approach to α‐branched aldehydes of type (III)/ (V) is reported.
ChemInform Abstract: Copper‐ and Amine‐Free Sonogashira—Hagihara Coupling Reaction Catalyzed by Pd(0) Nanoparticles Supported on Modified Crosslinked Polyacrylamide.
Authors: Tamami Bahman , Ghasemi Soheila 
Published: April 2012

AbstractThe method requires tetrabutylammonium bromide which acts as base and phase‐transfer catalyst.
ChemInform Abstract: Synthesis and Crystallography of 8‐Halonaphthalene‐1‐carbonitriles and Naphthalene‐1,8‐dicarbonitrile.
Authors: Noland Wayland e. , Narina Venkata Srinivasarao , Britton Doyle 
Published: April 2012

Abstract8‐Halonaphthalene‐1‐carbonitriles (V) are conveniently obtained in a three‐step synthesis using the ring opening of 1H‐naphthotriazine (II) with the corresponding hydrogen halides as the key step.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling of Aryl C—O Based Electrophiles with Aryl Neopentylglycolboronates.
Authors: Leowanawat Pawaret , Zhang Na , Percec Virgil 
Published: April 2012

AbstractThe efficiency concerning coupling of aryl mesylates, sulfamates, carbamates, pivalates, carboates, and methyl ethers with boronates (II) is found to depend on the conditions.
ChemInform Abstract: Synthesis of 2‐Bromo‐1H‐indenes via Copper‐Catalyzed Intramolecular Cross‐Coupling of gem‐Dibromoolefins.
Authors: Liu Peijun , Tao Kemei , Zhao Liwen , Shen Wang , Zhang Jincun 
Published: April 2012

AbstractCyclization of activated arylated alkyl esters with an adjacent gem‐dibromoolefin under conditions A) allows the preparation of various functionalized title compounds in moderate to good yields.
ChemInform Abstract: Titanium(IV)‐Promoted Regioselective Nucleophilic Ring‐Opening Reaction of Chiral Epoxyallyl Alcohols with Acids as a Tool for Ready Access to Chiral 1,2,3‐Triol Monoesters: Application to Stereoselective Total Synthesis of Macrolides.
Authors: Krishna Palakodety Radha , Ramana D. Venkata 
Published: April 2012

AbstractRing closing metathesis of the protected 1,2,3‐trol monoesters (Vb) and (VIII) provides a short route to natural macrolides like herbarumin I (V) and II (IX).
ChemInform Abstract: Regioselective Preparation of Benzo[b]furans from Phenols and α‐Bromoketones.
Authors: Arias Leire , Vara Yosu , Cossio Fernando P. 
Published: April 2012

AbstractAl2O3‐mediated treatment of activated phenols with α‐bromoacetophenones results in formation of 2‐substituted benzofurans.
ChemInform Abstract: Diastereo‐ and Enantioselective Synthesis of Fluorinated Proline Derivatives via Copper(I)‐Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition.
Authors: Li Qing , Ding Chang‐Hua , Li Xiao‐Hui , Weissensteiner Walter , Hou Xue‐Long 
Published: April 2012

AbstractOptimal conditions include a catalyst derived from commercially available chiral Walphos ligand.
ChemInform Abstract: Carbon—Carbon Bond‐Forming Reactions of α‐Thioaryl Carbonyl Compounds for the Synthesis of Complex Heterocyclic Molecules.
Authors: Biggs‐Houck James E. , Davis Rebecca L. , Wei Jingqiang , Mercado Brandon Q. , Olmstead Marilyn M. , Tantillo Dean J. , Shaw Jared T. 
Published: April 2012

AbstractSeveral methods for the C—C bond formation of α‐thioaryl carbonyl compounds are reported.
ChemInform Abstract: Stereoselective Synthesis of Geometrically Strained, Oxindole‐Appended Vinyl Cyclopropanes and Highly Substituted Cyclopentenes via Sulfur Ylide Cyclopropanation and Vinyl Cyclopropane Rearrangement.
Authors: Lingam Kandapalam Arun Prasath , Shanmugam Ponnusamy , Selvakumar Kodirajan 
Published: April 2012

AbstractAn initially formed sulfur ylide from allyl bromides (II) and dimethylsulfide reacts with oxoindolin‐3‐ylidenes (I) or styrene derivatives (VII) to give vinylcyclopropanes (III) and (VIII) with high diastereoselectivity.
ChemInform Abstract: N‐(Imidazolidin‐2‐ylidene)‐1‐arylmethanamine Oxides: Synthesis, Structure and Pharmacological Evaluation.
Authors: Saczewski Jaroslaw , Hudson Alan , Laird Shayna , Rybczynska Apolonia , Boblewski Konrad , Lehmann Artur , Ma Daqing , Maze Mervyn , Watts Helena , Gdaniec Maria 
Published: April 2012

AbstractAll the title compounds (V) and (VI) show very weak binding affinities to imidazoline I1 receptors, but some of them exhibit good affinity to the imidazoline I2 receptors.
ChemInform Abstract: Efficient One‐Pot Synthesis of 2‐Substituted Benzimidazoles from Triacyloxyborane Intermediates.
Authors: Cui Wenge , Kargbo Robert B. , Sajjadi‐Hashemi Zohreh , Ahmed Feryan , Gauuan Jolicia F. 
Published: April 2012

AbstractA novel protocol is presented for the synthesis of benzimidazoles (III) which can be extended to benzoxazoles by use of 2‐aminophenol.
ChemInform Abstract: Mechanism Selection for Regiocontrol in Base‐Assisted, Palladium‐Catalyzed Direct C—H Coupling with Halides: First Approach for Oxazole‐ and Thiazole‐4‐carboxylates.
Authors: Theveau Laure , Verrier Cecile , Lassalas Pierrik , Martin Thibaut , Dupas Georges , Querolle Olivier , Van Hijfte Luc , Marsais Francis , Hoarau Christophe 
Published: April 2012

AbstractBoth base‐assisted non‐concerted (nCMD) and concerted metallation—deprotonation (CMD) reactions are identified as potent operating mechanisms in palladoim‐catalyzed direct C—H couplings of oxazole and thiazole‐4‐carboxylates with halides.
ChemInform Abstract: Virtual Ligand Screening of α‐Glucosidase: Indentification of a Novel Potent Noncarbohydrate Mimetic Inhibitor.
Authors: Hakamata Wataru , Ishikawa Ryosuke , Ushijima Yoriko , Tsukagoshi Takumi , Tamura Saori , Hirano Takako , Nishio Toshiyuki 
Published: April 2012

AbstractAR122 (Ia) and AR125(Ib) constitute a new class of noncarbohydrate mimetic α‐glucosidase inhibitors with an irreversible mechanism.
ChemInform Abstract: An Efficient and Eco‐Friendly Synthesis of 14‐Aryl‐14H‐dibenzo[a,j]xanthenes Using H4[SiW12O40] as a Heterogeneous and Reusable Catalyst under Solvent‐Free Conditions.
Authors: Allameh S. , Davoodnia A. , Khojastehnezhad A. 
Published: April 2012

AbstractThe method is advantageous with regard to mild conditions, short times and high yields.
ChemInform Abstract: Stereoselective Synthesis of Novel Annulated Thiopyrano Indole Derivatives from Simple Oxindole via Intramolecular 1,3‐Dipolar Cycloaddition Reactions of Nitrone and Nitrile Oxide.
Authors: Majumder Swarup , Bhuyan Pulak J. 
Published: April 2012

AbstractTreatment of the aldehydes (I) with hydroxylamines (II) under basic conditions yields the title skeleton via nitrone formation followed by intramolecular 1,3‐dipolar cycloaddition.
ChemInform Abstract: Pyridines from Azabicyclo[3.2.0]hept‐2‐en‐4‐ones Through a Proposed Azacyclopentadienone.
Authors: Hemming Karl , Khan Musharraf N. , Kondakal Vishnu V. R. , Pitard Arnaud , Qamar M. Ilyas , Rice Craig R. 
Published: April 2012

AbstractThe azacyclopentadienone intermediate undergoes a Diels—Alder reaction with a styrene formed as by‐product during the cycloreversion of the bicyclic N‐systems.
ChemInform Abstract: One‐Pot Synthesis of Isoquinolinium Salts by Rhodium‐Catalyzed C—H Bond Activation: Application to the Total Synthesis of Oxychelerythrine (XII).
Authors: Jayakumar Jayachandran , Parthasarathy Kanniyappan , Cheng Chien‐Hong 
Published: April 2012

AbstractVarious substituted isoquinolinium salts are available by coupling of aromatic aldehydes with internal alkynes and primary amines under conditions A).
ChemInform Abstract: A Facile One‐Pot Synthesis of Substituted Thieno[2,3‐b]pyridines from Enaminones.
Authors: Gao Baochang , Dong Dewen , Zhang Jie , Ding Changjiang , Dong Chunming , Liang Yongjiu , Zhang Rui 
Published: April 2012

AbstractStepwise treatment of enaminones (I) with potassium carbonate and cyanothioacetamide followed by methylene‐active bromides (III) offers a synthesis of thieno[2,3‐b]pyridines (IV).
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed [2 + 2 + 2] Annulation of Allenoates with Trifluoromethylketones.
Authors: Sun Lihui , Wang Tong , Ye Song 
Published: April 2012

AbstractIn contrast to phosphine‐ and DABCO‐catalyzed reactions, the NHC‐catalyzed variant leads to [2 + 2 + 2] annulation products, e.g. (III) and (IV).
ChemInform Abstract: Microwave‐Assisted Synthesis, Hypolipidemic and Hypoglycemic Activity of Some Novel 2‐(4‐(2‐Amino‐6‐(4‐substituted phenyl)‐pyrimidin‐4‐yl)‐phenoxy)‐2‐methyl Propanoic Acid Derivatives.
Authors: Mokale Santosh N. , Elgire Rupali D. , Sakle Nikhil S. , Shinde Devanand B. 
Published: April 2012

AbstractAll products show significant antihyperlipidemic and antihyperglycemic activity compared to the standard drug.
ChemInform Abstract: Synthesis of 4‐Aminoquinazolines by Palladium‐Catalyzed Intramolecular Imidoylation of N‐(2‐Bromoaryl)amidines.
Authors: Van Baelen Gitte , Kuijer Sander , Rycek Lukas , Sergeyev Sergey , Janssen Elwin , de Kanter Frans J. J. , Maes Bert U. W. , Ruijter Eelco , Orru Romano V. A. 
Published: April 2012

AbstractA library of 4‐aminoquinazolines such as (V) or (VIII) are prepared.
ChemInform Abstract: Synthesis and Cytotoxicity Studies of Novel 2‐Hydrazonylpyrido[2,3‐b]pyrazin‐3(4H)‐ones.
Authors: Zhang Guogang , Liu Yajing , Wang Shuobing , Zhou Chuan , Huang Qingchang , Gong Ping 
Published: April 2012

AbstractFive of the target pyridopyrazinone derivatives (X) (24 examples), i.e.
ChemInform Abstract: Hydride Adducts of Dinitroquinolines in Multicomponent Mannich Reaction.
Authors: Medvedeva A. Yu. , Yakunina I. E. , Atroshchenko Yu. M. , Shumskii A. N. , Blokhin I. V. 
Published: April 2012

AbstractδH‐Adducts, generated by reduction of dinitro derivatives of 8‐oxyquinoline, 8‐oxyquinaldine, and 3,4‐dihydroquinolin‐2‐one with NaBH4 enter in multicomponent Mannich reactions furnishing pyridoazabicyclo[3.3.1]nonane derivatives in good yield.
ChemInform Abstract: Synthesis of Pyrrolidine and Tetrahydroazonine Derivatives from N‐[Bis(ethoxycarbonyl)methyl]tetrahydropyridinium Bromide and Methyl Acetylenedicarboxylate.
Authors: Soldatenkov A. T. , Soldatova S. A. , Suleimanov R. R. , Polyanskii K. B. , Kotsyuba V. E. , Smol'yakov A. F. , Khrustalev V. N. , Antipin M. Yu. 
Published: April 2012

AbstractThe base‐mediated reaction of acetylenedicarboxylate (II) with tetrahydropyridinium salt (I) affords predominantly pyrrolidine (III) or azonine (IV) depending on the reaction temperature.
ChemInform Abstract: Iridium‐Catalyzed Allylic Amination Route to α‐Aminoboronates: Illustration of the Decisive Role of Boron Substituents.
Authors: Touchet Sabrina , Carreaux Francois , Molander Gary A. , Carboni Bertrand , Bouillon Alexandre 
Published: April 2012

AbstractA variety of α‐amino trifluoroborates (III), (VIII) and (X) is prepared by Ir‐catalyzed allylic amination of trifluoroborate‐containing allylic carbonate (I) with secondary amines.
ChemInform Abstract: Diacenaphtho[1,2‐b;1′,2′‐d]silole and ‐pyrrole.
Authors: Nagasaka Yoshiharu , Kitamura Chitoshi , Kurata Hiroyuki , Kawase Takeshi 
Published: April 2012

AbstractHitherto unknown title compounds (IV) and (VI) are synthesized from bibromo‐1,1′‐biacenaphthylene derivative (II).
ChemInform Abstract: Stereoselective Synthesis of Allylsilanes Bearing Tetrasubstituted Olefin via 2,2‐Diborylethylsilane.
Authors: Endo Kohei , Sakamoto Akira , Ohkubo Takahiro , Shibata Takanori 
Published: April 2012

AbstractRegioselective deprotonation of 2,2‐diborylethylsilane (I) with lithium 2,2,6,6‐tetramethylpiperidide and subsequent nucleophilic addition to ketones lead to the corresponding allylsilanes in good to excellent yields and excellent stereoselectivity.
ChemInform Abstract: Synthesis, Conformational Analysis, and Evaluation as Glycosidase Inhibitors of Two Ether‐Bridged Iminosugars.
Authors: Jimenez‐Barbero Jesus 
Published: April 2012

AbstractRing isomerization of the polyhydroxylated azepanes (I) and (V) and subsequent debenzylative cyclization afford two bicyclic ether‐bridged iminosugars, (IV) and (VIII).
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed C‐Glycosylation: A Concise Approach from Stetter Reaction.
Authors: Vedachalam Seenuvasan , Tan Shi Min , Teo Hui Ping , Cai Shuting , Liu Xue‐Wei 
Published: April 2012

AbstractControlled by the conditions, either β‐selective acylation or acylation with concomitant elimination of the nitro group takes place.
ChemInform Abstract: Synthesis and Biological Activity of the Nucleoside Analogues Based on Polyfluoroalkyl‐Substituted 1,2,3‐Triazoles.
Authors: Kanishchev Oleksandr S. , Gudz Ganna P. , Shermolovich Yuriy G. , Nesterova Nadezhda V. , Zagorodnya Svetlana D. , Golovan Anna V. 
Published: April 2012

AbstractThe addition of 2‐N‐chlorotriazoles (I) to dihydropyran followed by base‐promoted dehydrochlorination leads to nucleoside mimetics (IV).
ChemInform Abstract: Synthesis of Novel 6′‐Spirocyclopropyl‐5′‐norcarbocyclic Adenosine Phosphonic Acid Analogues as Potent anti‐HIV Agents.
Authors: Liu Lian Jin , Kim Eunae , Hong Joon Hee 
Published: April 2012

AbstractThe new spirocyclopropyl nucleoside analogue (XI) and its SATE thioester prodrug (XIII) show promising anti‐HIV activity.
ChemInform Abstract: Synthesis of New 9‐Glycosyl‐4,9‐dihydropyrano[3,4‐b]indole‐1(3H)‐ones as Antibacterial Agents.
Authors: Kassab Shaymaa E. , Hegazy Gehan H. , Eid Nahed M. , Amin Kamelia M. , El‐Gendy Adel A. 
Published: April 2012

AbstractNovel glycosides (IIIb) and (IIId) show moderate antibacterial activity against several Gram‐negative and Gram‐positive bacteria.
Can We Predict the Site of Entry Tear by Computed Tomography in Patients With Acute Type A Aortic Dissection?
Authors: Takami Yoshiyuki , Tajima Kazuyoshi , Kato Wataru , Fujii Kei , Hibino Makoto , Munakata Hisaaki , Uchida Kenichiro , Sakai Yoshimasa 
Published: April 2012

AbstractBackground:In patients with acute type A aortic dissection (AAD), localization of the primary entry tear to be excluded is of major importance for intervention.Hypothesis:There are reliable indirect computed tomography (CT) findings to predict the entry site.Methods:In 83 patients with type A AAD whose primary entry tears were identified surgically between 2003 and 2009, we retrospectively examined the diagnostic CT scans regarding pericardial effusion, the largest short‐axial diameter of the aorta, widths of true and false lumens, and false lumen thrombosis at 6 levels of thoracic aorta from the aortic root to the descending aorta.Results:The primary entry sites identified intraoperatively were proximal ascending in 21 patients, middle ascending in 21, distal ascending in 21, arch in 17, and descending or unknown in 16. The multivariate logistic analysis revealed that pericardial effusion (odds ratio [OR]: 2.2, 95% confidence interval [CI]: 1.2–3.4, P < 0.001) and dilated ascending aorta (OR: 1.6, 95% CI: 1.1–2.4, P = 0.012) were the significant CT findings to predict the entry tear in the ascending aorta. It also revealed that the significant CT finding to predict the entry tear distal to the aortic arch was nonthrombosed false lumen in the descending aorta (OR: 1.2, 95% CI: 1.1–2.1, P = 0.048).Conclusions:We can predict the primary entry site by the preoperative CT findings in patients with type A AAD, considering pericardial effusion, aortic diameter, widths of true and false lumens, and false lumen thrombosis at different anatomic levels. Clin. Cardiol. 2012 DOI: 10.1002/clc.21991The authors have no funding, financial relationships, or conflicts of interest to disclose.