bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural studies of SNARE complex and its interaction with complexin by molecular dynamics simulation
Authors: Ghahremanpour Mohammad Mehdi , Mehrnejad Faramarz , Moghaddam Majid Erfani 
Published: January 2010

AbstractSince neurotransmitter releasing into the synaptic space delivers electrical signals from presynaptic neural cell to the postsynaptic cell, neurotransmitter secretion must be much orchestrated. Crowded intracellular vesicles involving neurotransmitters present a question of the how secretory vesicles fuse onto the plasma membrane in a fast synchronized fashion. Complexin is one of the most experimentally studied proteins that regulate assembly of fusogenic four‐helix SNARE complex to synchronized neurotransmitter secretion. We used MD simulation to investigate the interaction of complexin with the neural SNARE complex in detail. Our results show that the SNARE complex interacts with the complexin central helix by forming salt bridges and hydrogen bonds. Complexin also can interact with the Q‐SNARE complex instead of synaptobrevin to decrease the Q‐SNARE flexibility. The complexin alpha‐accessory helix and the C‐terminal region of synaptobrevin can interact with the same region of syntaxin. Although the alpha‐accessory helix aids the tight binding of the central helix to the SNARE complex, its proximity with synaptobrevin causes the destabilization of syntaxin and Sn1 helices. This study suggests that the alpha‐accessory helix of complexin can be an inhibiting factor for membrane fusion by competing with synaptobrevin for binding to the Q‐SNARE complex. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 560–570, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Elderly POSSUM, a dedicated score for prediction of mortality and morbidity after major colorectal surgery in older patients
Authors: Tran Ba Loc P , Tezenas du Montcel S , Duron J J , Levard H , Suc B , Descottes B , Desrousseaux B , Hay J M 
Published: January 2010

AbstractBackgroundSeveral scores have been developed to evaluate surgical unit mortality and morbidity. The Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity (POSSUM) and derivatives use preoperative and intraoperative factors, whereas the Surgical Risk Scale (SRS) and Association Française de Chirurgie (AFC) score use four simple factors. To allow for advanced age in patients undergoing colorectal surgery, a dedicated score—the Elderly (E) POSSUM—has been developed and its accuracy compared with these scores.MethodsFrom 2002 to 2004, 1186 elderly patients, at least 65 years old, undergoing major colorectal surgery in France were enrolled. Accuracy was assessed by calculating the area under the receiver operating characteristic curve (AUC) (discrimination) and calibration.ResultsThe mortality and morbidity rates were 9 and 41 per cent respectively. The E-POSSUM had both a good discrimination (AUC = 0·86) and good calibration (P = 0·178) in predicting mortality and a reasonable discrimination (AUC = 0·77) and good calibration (P = 0·166) in predicting morbidity. The E-POSSUM was significantly better at predicting mortality and morbidity than the AFC score (Pc = 0·014 and Pc &lt; 0·001 respectively).ConclusionThe E-POSSUM is a good tool for predicting mortality, and the only efficient scoring system for predicting morbidity after major colorectal surgery in the elderly.
Purification and characterization of Taq polymerase: A 9‐week biochemistry laboratory project for undergraduate students
Authors: Bellin Robert M. , Bruno Mary K. , Farrow Melissa A. 
Published: January 2010

AbstractWe have developed a 9‐week undergraduate laboratory series focused on the purification and characterization of Thermus aquaticus DNA polymerase (Taq). Our aim was to provide undergraduate biochemistry students with a full‐semester continuing project simulating a research‐like experience, while having each week's procedure focus on a single learning goal. The laboratory series has been taught for the past 7 years, and survey‐based assessment of the effectiveness of the laboratory series was completed during the 2006 and 2007 fall semesters. Statistical analysis of the survey results demonstrate that the laboratory series is very effective in teaching students the theory and practice of protein purification and analysis while also demonstrating positive results in more broad areas of scientific skill and knowledge. Amongst the findings, the largest reported increases in knowledge were related to students' understanding of how patent law relates to laboratory science, a topic of great importance to modern researchers that is readily discussed in relation to Taq polymerase. Overall, this laboratory series proves to be a very effective component in the curricula of undergraduate biology and chemistry majors and may be an appropriate laboratory experience for undergraduates.
Genomics and bioinformatics in undergraduate curricula: Contexts for hybrid laboratory/lecture courses for entering and advanced science students
Authors: Temple Louise , Cresawn Steven G. , Monroe Jonathan D. 
Published: January 2010

AbstractEmerging interest in genomics in the scientific community prompted biologists at James Madison University to create two courses at different levels to modernize the biology curriculum. The courses are hybrids of classroom and laboratory experiences. An upper level class uses raw sequence of a genome (plasmid or virus) as the subject on which to base the experience of genomic analysis. Students also learn bioinformatics and software programs needed to support a project linking structure and function in proteins and showing evolutionary relatedness of similar genes. An optional entry‐level course taken in addition to the required first‐year curriculum and sponsored in part by the Howard Hughes Medical Institute, engages first year students in a primary research project. In the first semester, they isolate and characterize novel bacteriophages that infect soil bacteria. In the second semester, these young scientists annotate the genes on one or more of the unique viruses they discovered. These courses are demanding but exciting for both faculty and students and should be accessible to any interested faculty member.
Problem‐solving test: Telomere replication
Authors: Szeberényi József 
Published: January 2010

AbstractTerms to be familiar with before you start to solve the test: DNA replication, template, primer, linear DNA, antiparallel orientation, telomere, origin of replication, chromatid, replicon, short tandem repeats, Okazaki fragments, leading strand, lagging strand, ribozyme, promoter, enhancer, terminal transferase, DNA polymerases, reverse transcriptase, RNA polymerase, topoisomerase, retroviral vector, Southern blotting, restriction endonuclease.
Teacher strategies simulation by using fuzzy systems
Authors: Aguilar R. M. , Muñoz V. , Noda M. , Bruno A. , Moreno L. 
Published: January 2010

AbstractFuzzy system technologies are of emerging interest in the specification and implementation of complex systems. This article introduces fuzzy instructional planner, which models the tutor module in a intelligent tutorial system (ITS). The behaviour of this system is defined by strategies which adapt the learning process for individual students by applying appropriate pedagogical methodologies. For this reason, the purpose of a instructional planner is to mimic the behaviour of the teacher able to control learning process satisfactorily. The knowledge acquisition is based on the reasoning carried out by the teacher in a learning process. Usually, this information is obtained from human expert who supplied linguistic information. The capacity to use linguistic information is specific to fuzzy inference systems. © 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 18: 183–192, 2010; Published online in Wiley InterScience (www.interscience.wiley.com); DOI 10.1002/cae.20128
Coalescence of Water Droplets in Crude Oil Emulsions: Analytical Solution
Authors: Bresciani A. E. , Alves R. M. B. , Nascimento C. A. O. 
Published: January 2010

AbstractIn petroleum refineries, water is used in desalting units to remove the salt contained in crude oil. Typically, 7 % of the volume of hot crude oil is water, forming a water‐and‐oil emulsion. The emulsion flows between two electrodes and is subjected to an electric field. The electrical forces promote the coalescence of small droplets of water dispersed in crude oil, and these form bigger droplets. This paper calculates the forces acting on the droplets, highlighting particularly the mechanisms proposed for droplet–droplet coalescence under the influence of an applied electric field. Moreover, a model is developed in order to calculate the displacement speed of the droplets and the time between droplet collisions. Thus, it is possible to simulate and optimize the process by changing the operational variables (temperature, electrical field, and water quantity). The main advantage of this study is to show that it is feasible to increase the volume of water recycled in desalting processes, thus reducing the use of freshwater and the generation of liquid effluents in refineries.
Synthesis of a Graphite Oxide Polyaniline Nano‐Composite by an Electrochemical Method
Authors: Rahimipour M. R. , Yazdani B. 
Published: January 2010

AbstractIn order to produce a polyaniline graphite oxide nano‐composite, electro‐polymerization of aniline was performed within the graphite oxide layers via electrochemical treatment of aniline‐intercalated graphite oxide in the supporting electrolyte. It was found that graphite oxide has special electro‐active properties. Therefore, electrochemical polymerization of aniline was performed on a Pt substrate in the presence of graphite oxide that had been dispersed in the electrolyte solution by the cyclic voltammetric method. Formation of polyaniline within the layers of graphite oxide occurred during electro‐polymerization. This mechanism affects the polyaniline morphology and leads to the formation of well‐defined concrete microstructures differing from the pure graphite oxide. Moreover, the results of the thermogravimetric analysis showed that graphite oxide and the polyaniline graphite oxide nano‐composite electrodeposited on the Pt substrate have different weight loss behaviors. This confirms that intercalation of the polyaniline improved the oxidation stability of graphite oxide, along with the fact that the polyaniline graphite oxide nano‐composite was successfully synthesized by an electrochemical method.
Sulfur Removal from Low‐Sulfur Gasoline and Diesel Fuel by Metal‐Organic Frameworks
Authors: Achmann S. , Hagen G. , Hämmerle M. , Malkowsky I. M. , Kiener C. , Moos R. 
Published: January 2010

AbstractSeveral materials in the class of metal‐organic frameworks (MOF) were investigated to determine their sorption characteristics for sulfur compounds from fuels. The materials were tested using different model oils and common fuels such as low‐sulfur gasoline or diesel fuel at room temperature and ambient pressure. Thiophene and tetrahydrothiophene (THT) were chosen as model substances. Total‐sulfur concentrations in the model oils ranged from 30 mg/kg (S from thiophene) to 9 mg/kg (S from tetrahydrothiophene) as determined by elementary analysis. Initial sulfur contents of 8 mg/kg and 10 mg/kg were identified for low‐sulfur gasoline and for diesel fuel, respectively, by analysis of the common liquid fuels. Most of the MOF materials examined were not suitable for use as sulfur adsorbers. However, a high efficiency for sulfur removal from fuels and model oils was noticed for a special copper‐containing MOF (copper benzene‐1,3,5‐tricarboxylate, Cu‐BTC‐MOF). By use of this material, 78 wt % of the sulfur content was removed from thiophene containing model oils and an even higher decrease of up to 86 wt % was obtained for THT‐based model oils. Moreover, the sulfur content of low‐sulfur gasoline was reduced to 6.5 mg/kg, which represented a decrease of more than 22 %. The sulfur level in diesel fuel was reduced by an extent of 13 wt %. Time‐resolved measurements demonstrated that the sulfur‐sorption mainly occurs in the first 60 min after contact with the adsorbent, so that the total time span of the desulfurization process can be limited to 1 h. Therefore, this material seems to be highly suitable for sulfur reduction in commercial fuels in order to meet regulatory requirements and demands for automotive exhaust catalysis‐systems or exhaust gas sensors.
A New Heteroleptic Ruthenium(II) Polypyridyl Complex with Long‐Wavelength Absorption and High Singlet‐Oxygen Quantum Yield
Authors: Zhou Qian‐Xiong , Lei Wan‐Hua , Chen Jing‐Rong , Li Chao , Hou Yuan‐Jun , Wang Xue‐Song , Zhang Bao‐Wen 
Published: January 2010

AbstractRuthenium(II) polypyridyl complexes with long‐wavelength absorption and high singlet‐oxygen quantum yield exhibit attractive potential in photodynamic therapy. A new heteroleptic RuII polypyridyl complex, [Ru(bpy)(dpb)(dppn)]2+ (bpy=2,2′‐bipyridine, dpb=2,3‐bis(2‐pyridyl)benzoquinoxaline, dppn=4,5,9,16‐tetraaza‐dibenzo[a,c]naphthacene), is reported, which exhibits a 1MLCT (MLCT: metal‐to‐ligand charge transfer) maximum as long as 548 nm and a singlet‐oxygen quantum yield as high as 0.43. Steady/transient absorption/emission spectra indicate that the lowest‐energy MLCT state localizes on the dpb ligand, whereas the high singlet‐oxygen quantum yield results from the relatively long 3MLCT(Ru→dpb) lifetime, which in turn is the result of the equilibrium between nearly isoenergetic excited states of 3MLCT(Ru→dpb) and 3ππ*(dppn). The dppn ligand also ensures a high binding affinity of the complex towards DNA. Thus, the combination of dpb and dppn gives the complex promising photodynamic activity, fully demonstrating the modularity and versatility of heteroleptic RuII complexes. In contrast, [Ru(bpy)2(dpb)]2+ shows a long‐wavelength 1MLCT maximum (551 nm) but a very low singlet‐oxygen quantum yield (0.22), and [Ru(bpy)2(dppn)]2+ shows a high singlet‐oxygen quantum yield (0.79) but a very short wavelength 1MLCT maximum (442 nm).
ChemInform Abstract: Ab initio Study of Structural, Dielectric, and Dynamical Properties of Zinc‐Blende ZnX (X: O, S, Se, Te).
Authors: Yu You , Zhou Jingjing , Han Huilei , Zhang Chuanyu , Cai Tuo , Song Chengqun , Gao Tao 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Vibrational Spectroscopy and Periodic DFT Studies of LaMg2PdH7: A Material with Two Types of Hydride.
Authors: Parker Stewart F. , Taylor Jon W. , Herman Henryk , Rapin Jean‐Philippe , Penin Nicolas , Yvon Klaus 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: LiSrGe2 and LiBaGe2: One‐Dimensional Chains of ∞1[Ge2]3‐ in an Unusual Conformation.
Authors: Park Dong Gon , Dong Yongkwan , DiSalvo Francis J. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Properties and Magnetic Structure of the Mn5Si3‐Type Tb5Si3 Compound.
Authors: Morozkin A. V. , Isnard O. , Nirmala R. , Malik S. K. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Spontaneous Magnetostriction of R2Fe13.6Si3.4 (R: U, Lu).
Authors: Andreev A. V. , Danis S 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phase Equilibria in Zr—Ni—Sb Ternary System at 870 K.
Authors: Romaka L. , Tkachuk A. , Stadnyk Yu. , Romaka V. A. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal Structure of New Titanyl Phosphate Sr2TiO(PO4)2.
Authors: Shpanchenko R. V. , Tsirlin A. A. , Hadermann J. , Antipov E. V. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solvothermal Syntheses of Two New Thiostannates and an in situ Energy Dispersive X‐Ray Scattering Study of Their Formation.
Authors: Pienack Nicole , Naether Christian , Bensch Wolfgang 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ln3Pb3(IO3)13 (μ3—O) (Ln: La—Nd): New Types of Second‐Order Nonlinear Optical Materials Containing Two Types of Lone Pair Cations.
Authors: Hu Ting , Qin Li , Kong Fang , Zhou Yong , Mao Jiang‐Gao 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure, and Properties of the [RuNO(NH3)5][Co(CN)6] Complex Containing a Photochromic Cation.
Authors: Kushch L. A. , Shilov G. V. , Il'in M. A. , Woike T. , Schaniel D. , Yagubskii E. B. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Complete Switch of Product Selectivity in Asymmetric Direct Aldol Reaction with Two Different Chiral Organocatalysts from a Common Chiral Source.
Authors: Nakayama Keiji , Maruoka Keiji 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Dynamic Kinetic Asymmetric Transformation in the α‐Hydroxylation of Racemic Malonates and Its Application to Biologically Active Molecules.
Authors: Reddy Dhande Sudhakar , Shibata Norio , Nagai Jun , Nakamura Shuichi , Toru Takeshi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Formation of Ring Structures Utilizing Multisite Activation by Indium Catalysis.
Authors: Itoh Yoshimitsu , Tsuji Hayato , Yamagata Ken‐ichi , Endo Kohei , Tanaka Iku , Nakamura Masaharu , Nakamura Eiichi 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cyclocondensation of α‐Acylacetamidines with Esters of 2‐Fluoro‐5‐nitrobenzoic and 4‐Chloro‐2‐methyl‐5‐pyrimidinecarboxylic Acids.
Authors: Dar'in D. V. , Ryazanov S. G. , Selivanov S. I. , Lobanov P. S. , Potekhin A. A. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2‐Iodoxybenzenesulfonic Acid as an Extremely Active Catalyst for the Selective Oxidation of Alcohols to Aldehydes, Ketones, Carboxylic Acids, and Enones with Oxone.
Authors: Uyanik Muhammet , Akakura Matsujiro , Ishihara Kazuaki 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Green and Efficient Oxidation of Benzylic Alcohols Using H2O2 Catalyzed by Montmorillonite K‐10 Supported CoCl2.
Authors: Ezabadi Ali , Najafi Ghloam Reza , Hashemi Mohammad M. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic Enantioselective Silylation of Acyclic and Cyclic Triols: Application to Total Syntheses of Cleroindicins D, F, and C.
Authors: You Zhen , Hoveyda Amir H. , Snapper Marc L. 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Al(OTf)3 — A Highly Efficient Catalyst for the Tetrahydropyranylation of Alcohols under Solvent‐Free Conditions.
Authors: Kamal Ahmed , Khan M. Naseer A. , Srikanth Y. V. V. , Reddy K. Srinivasa 
Published: January 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.