bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of Phloretin-loaded Nanospanlastics for Targeting of FAS/SREBP1c/AMPK/ OB-Rb Signaling Pathway in HFD-induced Obesity
Authors: Alamir Mohamed , Hussein Mohamed A. , Aboud Heba M. , Khedr Mohamed H. , Zanaty Mohamed I. 
Published: May 2024

Objectives:
Obese patients are at increased risk for CVD, which is the main cause of
premature death and has been a major cause of disability and ill health in recent years. PTN, a
natural dihydrochalcone flavonoid, has a variety of pharmacological characteristics. This article
aimed to prepare PTN-NSLs to evaluate their anti-obesity activity.

Methods:
Morphology, Particle size, zeta potential, UV-vis, entrapment efficiency, FT-IR spectra,
and an in vitro release study of PTN-NSLs were described. PTN-NSLs were also tested for
their anti-obesity properties in obese rats. The LD50 of PTN-NSLs was calculated, as was the
1/20 LD50 prepared for the treatment of obese rats. Also, the level of glycemic, oxidative stress
and inflammatory biomarkers were estimated in the obese rat’s model.

Results:
The synthesized PTN-NSLs were uniform, spherically shaped, and well dispersed with
no aggregation noted, with a size range of 114.06 ± 8.35 nm. The measured zeta potential value
of PTN-NSLs was -32.50.8 mv. Also, the UV spectra of PTN and PTN-NSLs have strong absorption
at 225 and 285 nm. Also, the LD50 of PTN-NSLs was found to be 2750 mg/kg.b.w.
Moreover, administrating obese rats with PTN-NSLs resulted in improved glycemic features as
well as GSH, SOD, GPx, GR, IL10, TBARs, and IL-6 levels, as well as attenuated FAS,
SREBP1c, AMPK, ACO, CPT1, and OB-Rb gene expression.

Conclusions:
Administration of PTN-NSLs significantly attenuated the levels of glycemic, oxidative
stress, and inflammatory biomarkers. The biochemical and PCR findings are aided by
histological investigations. Also, the present findings imply that PTN-NSLs might be a promising
pharmacological tool for the treatment of obesity-related diseases.
Assessment of Knowledge and Concern of People Living with HIV
Regarding Human Mpox and Vaccination
Authors: Borcak Deniz , Özdemir Yusuf Emre , Yesilbag Zuhal , Ensaroğlu Esra , Akkaya Samiha , Yaşar Kadriye Kart 
Published: May 2024

Introduction:
Mpox virus is an orthopoxvirus that causes the zoonotic infectious disease
known as mpox. The disease can also spread from humans to humans. It can be transmitted
through contact with bodily fluids, lesions on the skin, or internal mucosal surfaces.

Method:
The number of mpox cases increased during the COVID-19 pandemic. Early diagnosis
and prompt management of mpox are critical in people living with HIV (PLHIV). In this study, a
cross-sectional survey was conducted among PLHIV followed at the outpatient clinic between 20
April–20 August 2023. A questionnaire was used to assess the knowledge and anxiety levels of patients
as well as their opinions about vaccination against mpox. The severity of symptoms in the
past two weeks was assessed using the Generalised Anxiety Disorder 7-item scale. A total of 203
PLHIV were interviewed for this survey study.

Result:
The mean age was 39.37±11.93. The majority of them were male (86.7%), and 41.4%
were men who have sex with men (MSM). Only 21 of the surveyed participants (10.4%) had a
“good knowledge” score about mpox. The mean knowledge score on human Mpox was 2.05
(min:0-max:8), and 107 (52.7%) had a score of 0.

Conclusion:
The future study should focus on continuous education, promoting awareness
through programs and establishing measures to successfully overcome identified variables that
contribute to mpox pandemic understanding and attitudes. Applying the lessons learned from the
COVID-19 pandemic will help the management of mpox virus.
Analytical and Bioanalytical Methods for the Determination of Dipeptidyl Peptidase-4 Inhibitors in Various Matrices: A Comprehensive Review
Authors: Hadawale Sakshi , Sharma Sanjay 
Published: May 2024

Background:
DPP-4 inhibitors, or gliptins, are new oral antidiabetic drugs for type 2 diabetes.
They help to regulate insulin and glucagon. These drugs have the advantage of a lower risk of hypoglycemia
compared to some other diabetes medications and are typically prescribed when metformin
and sulphonylureas have become less effective.

Objective:
This review analyses a range of analytical and bioanalytical methods for DPP-4 inhibitors,
that use spectroscopic techniques, chromatographic, and hyphenated techniques for analysis. So far, no
review comprising all DPP-4 inhibitors has been presented. The primary objective of this review is to
present the analysts with various analytical and bioanalytical methods for the quantification and estimation
of DPP-4 inhibitors in different matrices.

Methods:
To improve understanding, a review was carried out by creating a database of pre-existing
research from digital sources such as ScienceDirect, and PubMed. The methodology is shown in the
flowchart of the literature selection process.

Conclusion:
The comprehensive assessment of methods for analysing DPP-4 inhibitors can be a valuable
resource for researchers and healthcare practitioners. Hitherto, no review encompassing all DPP-4
inhibitors has been presented. Therefore, gaps in the data available on a particular subject, need to be
required to collect data on a particular construct. The review suggests that chromatographic techniques
were majorly used for analysis wherein solvents like acetonitrile, methanol, and buffer solutions were
used as mobile phases that can deteriorate HPLC columns and equipment. So, scientists could investigate
new methods for the assessment of DPP-4 inhibitors using more eco-friendly solvents.
A Systematic Review of Herbal Interventions for the Management of
Cardiovascular Diseases
Authors: Wal Ankita , Verma Neha , Balakrishnan Senthil Kumar , Gahlot Vinod , Dwivedi Sumeet , Sahu Pankaj Kumar , Tabish Mohammad , Wal Pranay 
Published: May 2024

Background:
Cardiovascular diseases represent a significant global health burden,
necessitating diverse approaches for effective management. Herbal interventions have gained
attention as potential adjuncts or alternatives to conventional therapies due to their perceived
safety and therapeutic potential. This structured abstract provides a comprehensive review of
herbal interventions for the management of CVDs, summarising key findings, mechanisms of
action, and clinical implications.

Objective:
This systematic review aims to evaluate the impact of various herbal interventions
employed for managing cardiovascular diseases.

Method:
We conducted an extensive literature search across electronic databases, including
PubMed, Scopus, and Web of Science, from inception to 2022. Studies were included if they
investigated the use of herbal remedies for preventing or treating CVDs. Data extraction and
synthesis focused on botanical sources, active compounds, mechanisms of action, and clinical
outcomes.

Result:
Numerous herbal interventions have demonstrated promising cardiovascular benefits.
A number of medicinal herbs well identified to treat CVD are Moringaoleifera, Ginseng,
Ginkgo biloba, Celosia argentea, Gongronematrifolium, Gynostemmapentaphyllum, Bombaxceiba,
Gentianalutea, Allium sativum, Crataegusspp, Curcuma longa, Camellia sinensis, and
Zingiberofficinale. Mechanistic insights reveal that herbal interventions often target multiple
pathways involved in CVD pathogenesis. These mechanisms encompass anti-inflammatory,
antioxidant, anti-thrombotic, anti-hypertensive, and lipid-lowering effects. Additionally, some
herbs enhance endothelial function, promote nitric oxide production, and exert vasodilatory
effects, contributing to improved cardiovascular health. Clinical studies have provided evidence
of the efficacy of certain herbal interventions in reducing CVD risk factors and improving
patient outcomes. However, more rigorous, large-scale clinical trials are needed to establish
their long-term safety and effectiveness. It is crucial to consider potential herb-drug interactions
and standardise dosages for reliable therapeutic outcomes.

Conclusion:
This comprehensive review highlights the potential of herbal interventions as
valuable adjuncts or alternatives for managing cardiovascular diseases. Herbal remedies offer
diverse mechanisms of action, targeting key CVD risk factors and pathways. While promising,
their clinical utility warrants further investigation through well-designed trials to establish
their safety and efficacy, paving the way for integrated approaches to cardiovascular disease
management. Healthcare providers and patients should engage in informed discussions about
the use of herbal interventions alongside conventional therapies in the context of CVD prevention
and treatment.
Synergic Usage of Pistia stratiotes sp., Eichhornia crassipes sp., Typha angustifolia sp., and Lepironia Articulata sp. Plants for Sewage Treatment via Phytoremediation Technology
Authors: Hairolnizam Nurul Farah Anisa , Sulaiman Suryati , Razak Abdul Syukor Abd , Mokhtar Nadzirah Mohd , Mokhtar Nadiah , Aziz Azrina Abd , Chin Khor Bee 
Published: May 2024

Introduction
Domestic wastewater management is challenging on a worldwide level. The discharge of a large amount of nitrogen and phosphate from sewage accelerates pollution can lead to reduced oxygen levels, excessive algal blooms, the expansion of aquatic weed plants, and the destruction of the aquatic environment. As a result, the right wastewater treatment is required prior to discharge into natural water bodies in order to prevent contamination and fulfill the wastewater acceptable limits established by the government and environmental protection agencies. For Previous studies, most of the research is carried out in a controlled environment within a small time frame. Phytoremediation offers a viable alternative by harnessing the natural capabilities of plants to enhance the degradation and removal of pollutants in sewage.

Aims
The objective of this study is to evaluate the phytoremediation performance using Pistia stratiotes sp., Eichhornia Crassipes sp., Typha angustifolia sp., and Lepironia Articulata sp. in treating real domestic wastewater.

Methods
The phytoremediation system conducted continuous treatment at the Sewage Treatment Plant (STP) effluent at Selangor, Malaysia. To the best of our knowledge there are no studies conducted on the phytoremediation plant in real STP using 4 types of aquatic plants in a row to achieve a high percentage removal of pollutants. This research observation was conducted by collecting data every 2 weeks for 4 consecutive months including the maintenance terms. In terms of pollutant removal, the phytoremediation system showed the highest removal efficiency in all tested parameters.

Results
The highest removal efficiency recorded for biochemical oxygen demand (BOD), chemical oxygen demand (COD), total suspended solids (TSS) and ammoniacal nitrogen (AN) were 68.38%, 70.95%, 59.21% and 25.00%, respectively.

Conclusion
Following the guidelines of the Environmental Quality (Sewage Effluent) Regulation 2009 Malaysia, synergic usage of the aquatic plant had successfully achieved Standard A for sewage discharge after applying the phytoremediation technology while it has been proven that the environmentally friendly technologies can reduce the risk of water pollution by using the selected plant and may solve the water shortage with a cost-effective and efficient solution to wastewater treatment.
Attitude of “AAB College” Nursing Students Towards Scientific Research
Authors: Haxhija Edona , Shabani Zamira , Zylfo Armela , Shkoza Donika , Ramaj Arlinda 
Published: May 2024

Aims
AAB College is a non-public institution that dates back to 2017, and during its internal evaluation, the involvement of nursing students in scientific research has appeared problematic, so the purpose of this study is to first identify the attitude of nursing students towards scientific research only in this college later in the near future we will compare with a public institution.

Background
Since higher education institutions are subject to accreditation, and one of the key points is scientific research and the involvement of students in this process, we thought of investigating this issue. It is necessary for nursing students to have a culture of scientific research because this affects the increase of their performance in school, at work and also in the improvement of the quality of service to patients. Nursing students should be initiated into the research culture and adopt positive attitudes toward scientific research during their undergraduate education to improve the nursing profession, contribute to the professionalization of this profession, and maintain quality of care, nurse autonomy, and power. This research should transmit, promote, and protect knowledge in the improvement of teaching, scientific research, and community services.

Objective
Cross-sectional descriptive statistics were used to summarize the importance of research to nursing students, the time students spend on research, student attitudes toward science, how collaborative research professors were with students, and the motivation provided to students by faculty or professors.

Methodology
Data collection was carried out during January - June 2022. The sample was randomly selected. In this study, 300 students of “AAB College” were included. Students were given a questionnaire administered by us. To perform the statistical analysis, we used the SPSS program 19 version and Microsoft Office 2010.

Results
The minimum age of the students who were interviewed is 18 years. 64% of these students are female (n=192), and 36% are male (n=108).

Conclusions
The largest percentage of students state that scientific research is “Very important” for them. The lectures related to research in nursing have “a lot of influence” on their formation. Students spend “Enough” time or energy on scientific research. The faculty/college where they study does not offer them support for studies or scientific activities. The majority of students have not participated in any scientific activity, but students who have been active or passive participants in scientific activities are referred to being provided with training certificates. Students feel “enough” motivated to carry out scientific work in the nursing field.
Breath-holding Test in the Prognosis of Postoperative Pain in Laparoscopic Gynecology: Observational Cohort Study
Authors: Dmitriev Alexey , Trembach Nikita 
Published: May 2024

Background
The problem of perioperative pain relief has not lost its relevance over the years. Studies have shown that patients report moderate to severe pain after surgery, even after laparoscopy. In recent years, specialists have focused on the role of baroreflex sensitivity in the functional state of the nociceptive and antinociceptive systems. Studies have shown that a test with maximum breath-holding during inspiration allows for a non-invasive and accurate assessment of the functional state of the cardiorespiratory system, making it possible to identify a cohort of patients with reduced baroreflex sensitivity

Objective
The aim of the study was to assess the relationship between the breath-holding test and postoperative pain and to develop a model for predicting pain after laparoscopic gynecological surgery.

Methods
Data from 489 patients undergoing gynecological laparoscopy at the Clinic of the Kuban State Medical University from August 2019 to September 2023 were analyzed.

Results
Severe postoperative pain was reported in 146 patients (29.9%). The duration of breath-holding was statistically significantly correlated with NRS upon admission to the PACU at all time points of the study (from -0,15 to -0,21). Logistic regression showed that the Generalized Anxiety Disorder scale score, Pain Catastrophizing Scale score, duration of surgery, Breath-holding duration, and endometriosis surgery influenced the risk of severe postoperative pain (NRS 7-10) (AUROC 0,809).

Conclusion
The breath-holding test, along with other factors, may be useful in assessing the risk of severe postoperative pain after laparoscopic gynecology.
The Mass Gap in QCD and a Restriction on Gluon Masses
Authors: Larin Sergey. A. 
Published: May 2024

:
In this study, we prove that it is necessary to introduce the non-zero gluon masses into
the fundamental Lagrangian of Quantum Chromodynamics in order to describe the mass gap in
the reaction of electron-positron annihilation into hadrons. Further, in this work, a new restriction
on the gluon masses is imposed, and the renormalized theory with non-zero Lagrangian gluon
masses is presented
Barriers to and Facilitators of Key Stakeholders Influencing Successful Digital Implementation of Remote Monitoring Solutions: Mixed Methods Analysis
Authors: Iqbal Fahad Mujtaba , Aggarwal Ravi , Joshi Meera , King Dominic , Martin Guy , Khan Sadia , Wright Mike , Ashrafian Hutan , Darzi Ara 
Published: May 2024

Background
Implementation of remote monitoring solutions and digital alerting tools in health care has historically been challenging, despite the impetus provided by the COVID-19 pandemic. To date, a health systems–based approach to systematically describe barriers and facilitators across multiple domains has not been undertaken.

Objective
We aimed to undertake a comprehensive mixed methods analysis of barriers and facilitators for successful implementation of remote monitoring and digital alerting tools in complex health organizations.

Methods
A mixed methods approach using a modified Technology Acceptance Model questionnaire and semistructured interviews mapped to the validated fit among humans, organizations, and technology (HOT-fit) framework was undertaken. Likert frequency responses and deductive thematic analyses were performed.

Results
A total of 11 participants responded to the questionnaire and 18 participants to the interviews. Key barriers and facilitators could be mapped onto 6 dimensions, which incorporated aspects of digitization: system use (human), user satisfaction (human), environment (organization), structure (organization), information and service quality (technology), and system quality (technology).

Conclusions
The recommendations proposed can enhance the potential for future remote sensing solutions to be more successfully integrated in health care practice, resulting in more successful use of “virtual wards.”

Trial Registration
ClinicalTrials.gov NCT05321004; https://www.clinicaltrials.gov/study/NCT05321004
Indicadores antropométricos e de desempenho funcional não estiveram associados à incidência de quedas em pessoas idosas
Authors: De Almeida Viana Vanessa Cristina , Oliveira Carneiro José Ailton 
Published: May 2024

O estudo teve como objetivo investigar a associaçãoentre os indicadores antropométricos e de desempenho funcional com à incidência de quedas em pessoas idosas,e identificar possíveis indicadores capazes de predizer a incidência de quedas em 5 anos de seguimento. Trata-se de um estudo longitudinal prospectivo, aninhado a uma coorte, de caráter observacional e exploratório que utilizou dados coletados em 2014 e 2019. A populaçãodo estudo foi composta por 167 pessoas com idade ≥ 60 anos, de ambos os sexos. A variável dependente foi a ocorrência de quedas, verificada por meio do autorrelato com base nos últimos 12 meses. As variáveis independentes foram os indicadoresantropométricos (índice de massa corporal, relação cintura estatura, massa muscular total e circunferências da cintura e panturrilha), e os de desempenho funcional (teste de sentar e levantar, teste de caminhada). Amédia de idade da população geral foi de 72,3 ± 8,3 anos, a incidência de quedas para o sexo feminino foi de 27,4% e para o sexo masculino de 11,1%. Não houve associação entre os indicadores antropométricos e de desempenho funcional com à incidência de quedas (p>0,05). Conclui-se, que os indicadores estudados não influenciaram na ocorrência de quedas em pessoas idosas em um período de cinco anos.
Mortalidade por neoplasia de mama no município de Salvador - Bahia no período 2017 a 2019
Authors: Correia Messias Gladistone , Souza Alves Ruth 
Published: May 2024

A incidência do câncer de mama tende a crescer progressivamente a partir dos 40 anos, assim como a mortalidade por essa neoplasia. Em 2019, os óbitos por câncer de mama ocuparam o primeiro lugar no país, representando 16,1% do total de óbitos. O objetivo do estudo foi identificar o número de mulheres que vieram a óbito por ocorrência da neoplasia de mama na cidade de Salvador, Bahia no período 2017 a 2019. Trata-se de um estudo transversal descritivo com abordagem quantitativa. Os dados referentes à mortalidade por neoplasia de mama foram coletados por meio do DATASUS e SIM no período de 2017 a 2019. A taxa de mortalidade aumentou de 20,25 para 24,02 em Salvador durante o período analisado. O maior número de casos de óbitos por câncer de mama ocorreu com mulheres de cor de pele parda (50,24%), com faixa etária entre 50 a 59 anos representando 23,24% e com escolaridade de 8 a 11 anos (27,58%) durante o período analisado. Com o passar dos anos houve um aumento do número de óbitos pelo câncer de mama. Constata-se que a sobrevida das mulheres pode ser prolongada quando a doença é diagnosticada em estádios mais precoces. As estratégias para conscientizar a população feminina na prevenção da doença, são necessárias para o diagnóstico precoce, tratamento adequado do câncer de mama.
Impacto do edentulismo no estado nutricional de idosos: uma revisão integrativa
Authors: Sobreira Machado Israel , Freires de Alencar Arrais Joel 
Published: May 2024

Introdução: A alimentação é imprescindível para a sobrevivência humana, sendo necessária para garantir o fornecimento de nutrientes para sustentar suas atividades diárias. A mastigação eficiente, com a participação de dentes completos, assim como uma musculatura bucal forte e eficaz, é essencial para desfrutar de uma alimentação prazerosa. Objetivo: Analisar as implicações da falta de dentes no estado nutricional de pessoas idosas. Metodologia: Trata-se de uma revisão integrativa que abrangeu os artigos publicados entre 2018 e 2023, acessíveis gratuitamente e em texto completo nas bases de dados SciELO, LILACS, PubMed e Cochrane Library. Foram incluídos estudos que envolviam indivíduos idosos, com idade igual ou superior a 60 anos, que apresentassem perda total ou parcial dos dentes. Resultados: Foram encontradas 200 publicações. Após aplicação dos critérios de elegibilidade, três artigos foram incluídos na amostra. Todos os artigos empregaram metodologias transversais. A amostra contou com a participação de 3.332 idosos, cujas idades médias variaram entre 71 e 94,1 ± 3 anos. Conclusão: Foi percebido que de fato há uma relação significativa entre a falta total ou parcial de dentes em idosos e seu estado nutricional (desnutrição/risco de desnutrição). No entanto, vale ressaltar que os autores não foram enfáticos nessa correlação, tornando necessário realizar mais estudos que comprovem de forma efetiva a relação direta entre a ausência de dentes e o estado nutricional.