bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcutaneous auricular vagus nerve stimulation inhibits mental stress‐induced cortisol release—Potential implications for inflammatory conditions
Authors: Cuberos Paredes Ely , Goyes Domenica , Mak Sadie , Yardimian Raffi , Ortiz Nickolas , McLaren Ayana , Stauss Harald M. 
Published: February 2025

AbstractElevated glucocorticoid levels with reduced glucocorticoid responsiveness have been reported in chronic inflammatory conditions. Activation of neurons in the nucleus of the solitary tract by transcutaneous auricular vagus nerve stimulation (taVNS) may activate inhibitory pathways projecting to the hypothalamic paraventricular nucleus (PVN), thus inhibiting corticotropin‐releasing hormone (CRH) release and improving glucocorticoid dysfunction in chronic inflammatory conditions. Healthy adults (n = 12) participated in experimental (taVNS) and control (sham‐taVNS) sessions at least 4 days apart. A 30‐min baseline recording was followed by 30 min of taVNS or sham‐taVNS and 40 min of recovery. Ten minutes into taVNS or sham‐taVNS, a mental arithmetic stress test (MAST) was conducted for 15 min. The MAST increased heart rate, low frequency (LF) heart rate variability (HRV), and the LF to high frequency ratio of HRV, confirming sympathetic activation. Salivary cortisol levels during the MAST were lower during taVNS (49.5 ± 48.0% from baseline; mean ± SD) compared to sham‐taVNS (106.0 ± 81.1% from baseline; mean ± SD; p < 0.05). In a psoriasis patient, daily taVNS for 3 months reduced diurnal salivary cortisol levels from 58.2 ± 35.2 (ng/mL)*h (mean ± SD) to 34.9 ± 13.8 (ng/mL)*h (mean ± SD). While it is possible that taVNS inhibited CRH‐releasing neurons in the PVN, our study design did not allow to confirm this potential mechanism.
Erzsébet királyné magyarországi portréi
Authors: Borovi Dániel 
Published: February 2025

Bár a 19. századi magyar és a birodalmi közjogban az uralkodó felesége nem játszott tényleges szerepet, Erzsébet királyné a hatvanas évek végétől, politikai szerepvállalásának epizódjától kezdve mind gyakrabban jelent meg a közintézmények falain. A portrék leggyakoribb vizuális forrása Emil Rabending 1866-os fotósorozata volt, amely magyar díszruhában ábrázolta az uralkodónét. Erzsébet a kiegyezést követően nem vállalt tevékeny szerepet a magyar közéletben, bár gesztusokat továbbra is tett. A hatvanas évek végétől semmilyen fényképfelvételt nem készíttetett magáról. Magyarországon a fiatal, magyar ruhás Erzsébet ábrázolási típusa így egyre általánosabbá vált. A halála után a reprezentatív portrékból az emlékművekbe való átmenet emiatt szinte teljesen zavartalan volt. A királyné posztumusz között kivételesnek számítanak azok a festmények, melyeket a király rendelt meg magyar művészektől, hogy azokat ajándékba adja az Erzsébet mellett korábban udvari szolgálatot teljesítő hölgyeknek. A festmények mindegyike az idősebb, „civil” királynét ábrázolja; közülük a Ferenczy Ida számára Benczúr Gyula által készített portré Erzsébet egyik legismertebb magyarországi ábrázolása lett.

Fotó: Wikipedia
О СВОЙСТВАХ РАЗНОСТНЫХ СХЕМ ДЛЯ РЕШЕНИЯ НЕЛИНЕЙНО-ДИСПЕРСИОННЫХ УРАВНЕНИЙ ПОВЫШЕННОЙ ТОЧНОСТИ. II. СЛУЧАЙ ДВУХ ПРОСТРАНСТВЕННЫХ ПЕРЕМЕННЫХ
Authors: ФЕДОТОВА З.И. , ХАКИМЗЯНОВ Г.С. , ГУСЕВ О.И. 
Published: February 2025

Для случая двух пространственных переменных построена конечно-разностная схема типа предиктор-корректор для решения нелинейно-дисперсионных уравнений волновой гидродинамики с повышенным порядком аппроксимации дисперсионного соотношения. Численный алгоритм основан на расщеплении исходной системы уравнений на гиперболическую систему и скалярное уравнение эллиптического типа. Рассмотрены два способа аппроксимации эллиптической части. Для каждого из разработанных вариантов разностной схемы выполнен диссипативный и дисперсионный анализ, получены условия устойчивости, проанализированы формулы для фазовой ошибки, а также изучено поведение коэффициента затухания гармоник. Проведен сравнительный анализ с целью выявления преимущества каждой из схем.
For the case of two spatial variables, a finite-difference scheme of the predictor--corrector type is constructed for solving nonlinear dispersion equations of wave hydrodynamics with a higher order of approximation of the dispersion relation. The numerical algorithm is based on splitting the original system of equations into a hyperbolic system and a scalar equation of the elliptic type. Two methods of approximating the elliptic part are considered. For each of the variants of the difference scheme, dissipation and dispersion analysis is performed, stability conditions are obtained, formulas for the phase error are analyzed, and the behavior of the harmonic attenuation coefficient is studied. A comparative analysis is carried out to identify the advantages of each of the schemes.
An Extra Pair of Hands: A Story of Caring, Aging and Everyday Acts of Love - KATE MOSSE
Authors: Pelser Elzette 
Published: February 2025

In this book Kate Moss tells her personal story of finding herself as a caregiver in middle age: first, helping her mother look after her father through Parkinsons, then supporting her mother in widowhood, and finally as "an extra pair of hands" for her 90-year-old mother-in-law.
Teaching information literacy skills to Divyangjans and inspire them to acquire new knowledge for life-long learning
Authors: Bhatt Jay J 
Published: February 2025

As new educational and research initiatives become increasingly interdisciplinary, it is imperative that librarians worldwide develop and implement new approaches to the dissemination of various research tools and techniques. Many institutions and organizations have evolved, with tremendous potential for future growth, in response to the continued increase in demand for emerging technologies for sustained community growth. But, how about information resources, teaching, and educating Empowerment of Persons with Disabilities, Divyangjans? How do we envision programs to facilitate empowerment and inclusion of them? What are the roles of libraries from the information literacy perspectives? I will use Autism as one example where we can explore what information professionals, libraries, educators, teachers, and volunteers can work together in the spirit of well-being of this community. Various strategies of gathering, connecting, evaluating, and using information efficiently will be addressed during this talk. It is hoped that this will also contribute to life-long learning that can be transferred in future professional and academic activities to continue to contribute towards economic and sustained growth of global communities.
WITHDRAWN: Contamination Analysis of Coal Ash and Treated Marine Clay
Authors: Jamaludin Nadiah , Yunus Nor Zurairahetty Mohd , Jusoh Siti Norafida , Zolkepli Muhammad Farhan , Mohammed Ahmed Mohammed Awad 
Published: February 2025

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Potential use of Piper peltatum essential oil for the control of Moniliophthora roreri in cacao plants cultivated in the Colombian Amazon region
Authors: Martinez Anyi Paola Gómez , Ortíz Sonia Patricia Sánchez , Rodríguez Lyda Constanza Galindo , Álvarez Liceth Natalia Cuéllar , Beltrán Gloria Magally Paladines , Motta Dúber Mora , Moyano Edgar Martinez 
Published: February 2025

Abstract

Cocoa (Theobroma cacao L.) is one of the main species of the peasant agroforestry system in many regions of Colombia and is considered one of the crops with the greatest economic projection, given its industrial demand and food importance. Production yields in the country are limited by various factors, with fungal diseases being a major challenge. Consequently, there is a strong need to develop safe and effective phytosanitary solutions to manage these diseases, reduce losses, and enhance productivity. The objective of the present study was to evaluate the antifungal potential of 4 concentrations (500, 1000, 2000 and 5000 ppm) of root, leaf and stem extracts of the Piper peltatum plant for the control of the fungus Moniliophthora roreri. For this, the fungus was collected and isolated from cocoa pods (T. cacao) and morphologically characterized. The results allowed to determine that P. peltatum in root extracts presents total phenol values ​​of 63 mg A.G g-1 and flavonoids of 74.88 mg CAT/g-1 and antioxidant activity greater than 200 mg Tx/g-1, ABTS. with values ​​of 300 mg Tx/g-1 and FRAP greater than 100 mg AA/g-1. Finally, the concentrations of Piper peltatum extracts showed an inhibition of mycelial growth greater than 88% in all concentrations and plant organs evaluated, highlighting the high potential of Piper peltatum as a controlling agent of Moniliophthora roreri in Cocoa crops in the Colombian Amazon region.
Insights into the nuclearity and local environment of transition metal species in ion-exchanged CHA zeolites and effects on the oxidation of methane
Authors: Yokoi Toshiyuki , Xiao Peipei , Wang Lizhuo , Nishibori Maiko , Nakamura Kengo , Wang Yong , Huang Jun , Gies Hermann 
Published: February 2025

Abstract

Ion-exchange method is a popular and facile way to prepare metal-containing zeolites, and transition-metal-exchanged zeolites have been widely used for the activation of small molecules such as CO₂, CH₄, and NH3, focusing on their transformation into valuable products or environmentally friendly chemicals. Understanding the exchange way between metal ions and zeolite and inferring the local environment of metal species is crucial to comprehending and predicting the activity of metal-exchanged zeolite catalysts. Herein, the frequently employed early transition metals (Fe3+, Co2+, and Cu2+) were adopted to exchange with CHA-type aluminosilicate zeolite (SSZ-13). The acidity of transition-metal-exchanged CHA zeolites was measured by NH3-TPD, and the metal speciation was identified by HAADF-STEM images, UV-vis, and XAS spectra. The linear trend line of the strong acid content and the metal/Al ratio of exchanged catalysts was used to calculate the ion-exchanged degree between metal cations and acidic protons of zeolite. The exchanged ratios of n:1 (n˃2), 1:2, and 1:1 for Fe, Co, and Cu/CHA zeolites specified the possible nuclearity and local environment of metal species. Therefore, these zeolite catalysts exhibited completely different reaction characteristics toward direct and continuous oxidation of methane using N2O as the oxidant. Taking full advantage of these features, high performance in N2O decomposition, direct conversion of methane to hydrocarbon via methanol as the intermediate, and direct conversion of methane to methanol with high methanol selectivity were realized by Fe, Co, and Cu-exchanged CHA zeolites, respectively. These findings provide guidance and reference for preparing metal-ion-exchanged zeolite catalysts and their suitable applications.
To Reduce Bias, Marinate for 11 Days? A Randomized Controlled Evaluation of a Multi-Day Racial Equity Challenge
Authors: Darling-Hammond Sean 
Published: February 2025

Abstract

Racial bias trainings are ubiquitous. Yet, they rarely deviate from a standard formula, and are rarely evaluated using rigorous research methods. This pre-registered study uses a randomized controlled trial design to estimate the causal impact of employee participation in the Racial Equity Challenge—a scaffolded, eleven-day antibias training that allows participants to explore a variety of topics through readings, videos, and activities. We find that while the Racial Equity Challenge did not impact motivation to reduce bias, it caused statistically significant increases in employees’ knowledge of bias, ability to navigate ambiguous workplace situations in ways that might reduce bias, belief that they know how to combat bias, and willingness to donate to the Black Lives Matter Foundation. We present implications regarding how to design and refine trainings so that they might reduce bias and enhance equity in workplaces and beyond.
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum
Authors: Chiosis Gabriela , Bay Sadik , Rodina Anna , Haut Florence , Roychowdhury Tanaya , Argyrousi Eleni K , Staniszevski Agnieszka , Han Kyung , Sharma Sahil , Chakrabarty Souparna , Digwal Chander , Stanisavljevic Aleksandra , Labuza Amanda , Alldred Melissa J. , Panchal Palak , Anand Ramaian , Tuffery Laura , Li Zhuoning , Hashmi Arsalan , Rosiek Eric , Chan Eric , Monetti Mara , Sasaguri Hiiroki , Saido Takaomi , Schneider Julie , Bennett David , Fraser Paul , Erdjument-Bromage Hediye , Neubert Thomas , Ginsberg Stephen D. , Arancio Ottavio 
Published: February 2025

Abstract

Alzheimer’s disease (AD) progresses as a continuum, from preclinical stages to late-stage cognitive decline, yet the molecular mechanisms driving this progression remain poorly understood. Here, we provide a systems-level map of protein-protein interaction (PPI) network dysfunction across the AD spectrum and uncover epichaperomes—stable scaffolding platforms formed by chaperones and co-factors—as central drivers of this process. Using over 100 human brain specimens, mouse models, and human neurons, we show that epichaperomes emerge early, even in preclinical AD, and progressively disrupt multiple PPI networks critical for synaptic function and neuroplasticity. Glutamatergic neurons, essential for learning and memory, exhibit heightened vulnerability, with their dysfunction driven by protein sequestration into epichaperome scaffolds, independent of changes in protein expression. Notably, pharmacological disruption of epichaperomes with PU-AD restores PPI network integrity and reverses synaptic and cognitive deficits, directly linking epichaperome-driven network dysfunction to AD pathology. These findings establish epichaperomes as key mediators of molecular collapse in AD and identify network-centric intervention strategies as a promising avenue for disease-modifying therapies.
Reductions in the future agricultural workday due to climate change
Authors: Zulueta Naia Ormaza , Mehrabi Zia 
Published: February 2025

Abstract

Agricultural workers are vital to global food security, yet their vulnerability to climate change remains understudied. Here, we integrate high-resolution hourly heat stress projections with new gridded global data on the agricultural workforce to quantify reductions in the agricultural workday from climate change. By 2050, the global agricultural workforce is projected to rise from 1.30 to 1.33 billion, with workers exposed to over 100 days of heat stress annually increasing from 359 to 663 million. Under SSP2-4.5, 3\% of the harvest season and 8\% of a standard workday (9am-5pm) will be lost globally to unsafe conditions, rising to 4\% and 11\% under SSP5-8.5. In tropical and coastal regions of South Asia, East Asia, and Sub-Saharan Africa, extreme heat will infringe evening hours, challenging adaptation strategies like shifting work to cooler times. This highlights an urgent need to improve policy with enhanced climate-resilient strategies to protect the world's agricultural workforce.
Chromosome-level genome assembly of trypanosomatid parasite Lotmaria passim links chromosome duplication and divergence with infection of honey bees
Authors: Nearman Anthony , Butenko Anzhelika , Evans Jay D , Palmer-Young Evan C 
Published: February 2025

Abstract

Background. The protist family Trypanosomatidae includes parasites of insects, vertebrates, plants, and even other unicellular eukaryotes. The genomes of these species harbor clues to the evolution of parasitism, adaptation to novel hosts, and infection of mammals. We present an analysis of a chromosome-level genome assembly of Lotmaria passim, the most prevalent known trypanosomatid of honey bees, linking genome sequence and organization to gene expression and infection of bees.
Results. The genome showed high synteny with assemblies of other trypanosomatids and especially closely related Leptomonas pyrrhocoris relatives. It included four copies of chromosomes that shared ancestry with the tetrasomic Leishmania Chromosome 31 and are consistently supernumerary throughout Trypanosomatidae. However, these chromosomes showed lower similarity to L. passim relatives than did the genome overall, with sufficient variation across haplotypes to distinguish two separate disomic chromosomes. Transcriptomic analyses showed that these chromosomes are enriched in genes upregulated during bee infection, and each include five paralogs of the GP63 gene implicated in infection of both insects and mammals. Patterns of expression in bees suggested decreased protein synthesis, a shift from carbohydrate- to amino acid-based metabolism, and reduced cell motility in bee guts versus cell culture. In contrast, genes involved in cell adhesion were upregulated, consistent with the importance of attachment to insect tissue in this species and the family overall.
Conclusions. Our analysis links differentiation of a conserved supernumerary chromosome with infection of bees, parallel tothis chromosome’s role in Leishmania infection of mammals and linking chromosome-level changes with adaptation to new hosts.
The Relationship Between Anti-Phosphatidylserine/Prothrombin Antibodies and Pregnancy Loss in Women with a History of Spontaneous Miscarriage: A Retrospective Single-Center Study
Authors: Xiang Junmiao , Pan Yundong , Pan Qianruo , Bao Ruru , Cai Zhuhua 
Published: February 2025

Abstract

Introduction:
Anti-phosphatidylserine/prothrombin antibodies (aPS/PT) have been proposed as diagnostic markers for antiphospholipid syndrome (APS). However, their role in predicting pregnancy outcomes, particularly in early and late pregnancy loss, remains uncertain. The mediating effects of immune and coagulation biomarkers in these associations are also poorly understood.
Methods
This retrospective single-center study included 678 pregnant women with a history of at least one spontaneous miscarriage, comprising 163 cases of pregnancy loss (140 early and 23 late) and 515 live births. Multivariable logistic regression and stratified analyses were used to evaluate the relationships between aPS/PT IgM, IgG, and pregnancy loss. Receiver operating characteristic (ROC) curves assessed the diagnostic performance of aPS/PT antibodies, while mediation analyses explored the influence of immune and coagulation biomarkers.
Results
Elevated levels of aPS/PT IgM and IgG were significantly associated with increased pregnancy loss risk. After full adjustment, the odds ratio (OR) for aPS/PT IgM was 1.024 (95% CI = 1.008–1.041; P = 0.004; AUC = 58.7%) and for aPS/PT IgG was 1.027 (95% CI = 1.007–1.047; P = 0.008; AUC = 58.8%). These associations followed a linear dose-response relationship, particularly for early pregnancy loss, with ORs of 1.023 (95% CI = 1.006–1.040; P = 0.009) for IgM and 1.025 (95% CI = 1.004–1.046; P = 0.021) for IgG. No significant associations were found with late pregnancy loss, and mediation analyses revealed no significant influence of immune or coagulation biomarkers.
Discussion
This study highlights aPS/PT IgM and IgG antibodies as independent risk factors for pregnancy loss, particularly in early gestation. These findings underscore the diagnostic potential of these markers and their utility in improving risk stratification and guiding targeted therapeutic interventions for women with a history of spontaneous miscarriage.
Standard Earthquakes Model Originated from the 2 Burridge and Knopoff Glissade Paradigm
Authors: GARZÓN RICARDO CEBALLOS , NECHEV PLAMEN NETCHEV 
Published: February 2025

Abstract

The paper is dedicated to the classical glissade’s modeling in order to explain the earthquake mechanisms. The B&K model, converted into a conception already well marked and known by everyone, has been rethought generalizing the uniform movement of the largest stratum, corresponds to any continually acting force. In addition, for the resistance function has been used an expression obtained by the authors, based on the Elementary Catastrophes Theory that resistance fully satisfies the conditions of the existence and uniqueness theorem regarding the solutions of the systems of ODE. Our generalized B&K model equations have been solved numerically for a particular case through the respective standard software package MATLAB. The analysis of the results highlights a periodicity at the seismic activity (obtained at constant force) and the earthquake’s appearances it is shown as a consequence of the different system’s resonance points. All of the above would allow through the reengineering methods obtaining valuable information related to the structure and behavior of local plates. With this, we dared to suppose that in view of future landslide models already there is available a “standard” basic description that we believe is essential to be included at the time of any further development.
Measuring the human dimensions of water insecurity in Arctic and sub-Arctic regions: a narrative review
Authors: Daley Angela , Daley Kiley , Bell Kathleen P. , Jain Shaleen 
Published: February 2025

ABSTRACT

Water (in)security is central to achieving sustainable development in Arctic communities. To characterize the pervasive and place-based challenges faced by Arctic residents and communities, water insecurity can be examined across five dimensions (i.e., availability, accessibility, safety, reliability and preference). Based on an analysis of 61 studies, this narrative review synthesizes how the human dimensions of Arctic water insecurity have been measured in the scientific literature. This review serves as a resource for researchers, policymakers and practitioners when selecting measures of water insecurity based on past studies, and for addressing knowledge gaps through the development of new measures in partnership with Arctic and Indigenous communities. Faced with rapid climatic and societal change, enhanced human-centered measures of water insecurity in the Arctic will enable future research, policy, monitoring, management and stewardship. This is necessary to achieve the human right to water and Sustainable Development Goal of clean water and sanitation for all.
Assessing groundwater abstraction and salt accumulation in the unconfined aquifer of Rachna Doab, Pakistan: a modeling approach
Authors: Shauket Imran , Nasir Abdul , Ali Sikandar , Aslam Zubair 
Published: February 2025

ABSTRACT

Groundwater is a critical resource facing growing threats from overuse and contamination globally. This study examines uncontrolled groundwater extraction and salt accumulation in the Rachna Doab region using ArcGIS, MODFLOW, and MT3DMS algorithms combined with a finite-difference numerical technique. Geological, hydrological, and hydrogeological data were analysed to assess groundwater level decline and total dissolved solids (TDS) concentration. The model was calibrated using piezometric data and TDS concentrations (2009–2016) and validated with data from 2017–2021, showing strong correlations between estimated and observed values. Two pumping scenarios for 2027 were considered: maintaining current pumping rates (Scenario I) and increasing rates based on future trends (Scenario II). Simulations indicated that water samples near Samundri Drain had the highest TDS concentrations, highlighting the impact of wastewater drains and saline groundwater. Groundwater samples revealed that higher pumping rates and poor-quality deeper groundwater are primary causes of saline intrusion.