bluuebunny/crossref_metadata_2025_split huggingface dataset:
Currarino syndrome with pelvic neuroendocrine tumor diagnosed by post‐mortem genetic analysis of tissue specimens
Authors: Ciotti Paola , Mandich Paola , Bellone Emilia , Ceppa Paola , Bovio Marta , Ameri Pietro , Torre Giancarlo , Fiocca Roberto , Murialdo Giovanni 
Published: September 2011

AbstractCurrarino syndrome (CS) is an autosomal dominant disorder of embryonic development characterized by the triad of anorectal abnormalities, partial sacral agenesis, and presacral mass. Mutations of the HLXB9 gene have been identified in most CS cases, but a precise genotype–phenotype correlation has not been described so far. We report the clinical case of a 44‐year‐old Caucasian woman with malignant neuroendocrine transformation of a pre‐sacrococcygeal mass combined with bicornuate uterus, dermoid cyst of the ovaries, and chronic constipation. After the patient died, a sacrococcygeal malformation and anterior meningocele were diagnosed in her 22‐year‐old son. CS diagnosis was then retrospectively confirmed by molecular analysis of normal and pathological tissue specimens of the mother, with identification of a HLXB9 mutation (c.727C>T; p.R243W). CS should be considered, and genetic counseling recommended, to all patients with presacral masses. Since malignant neuroendocrine transformation of presacral mass in CS is a possible complication, even thought rare, close follow up in these patients is advisable. © 2011 Wiley Periodicals, Inc.
Various scenarios of metal‐insulator transition in strongly correlated materials
Authors: Kuneš J. , Anisimov V.I. 
Published: September 2011

AbstractWe review our investigations of electronic properties of strongly correlated materials using the combination of first principles electronic band structures and the dynamical mean‐field theory, so called LDA+DMFT method. Our investigations focus on two phenomena, the spin state transitions and their relationship to the metal‐insulator transition, and the effect of hybridization between correlated and ligand orbitals in charge‐transfer type materials. The pressure driven spin transitions are studied for a group of materials containing MnO, FeO and Fe2O3. To investigate the hybridization effects we focus on NiO and NiS(Se)2. We identify various mechanisms of the metal‐insulator transition, which can take place in multi‐band systems, in addition to the band‐width control known from the single band Hubbard model.
The N‐terminal replacement of an olfactory receptor for the development of a Yeast‐based biomimetic odor sensor
Authors: Fukutani Yosuke , Nakamura Tomoko , Yorozu Maiko , Ishii Jun , Kondo Akihiko , Yohda Masafumi 
Published: September 2011

AbstractFor the development of a biomimetic odor‐sensing system, we investigated the effects of replacing the N‐terminus of an olfactory receptor (OR) on its functional expression in the budding yeast, Saccharomyces cerevisiae. Using the mouse olfactory receptor OR226 (mOR226), three types of chimeric ORs were constructed by replacing N‐terminal regions of mOR226 with the corresponding regions of the rat I7 receptor, which is known to be functionally expressed in yeast. The replacement of the N‐terminal region of mOR226 dramatically affected the expression and localization of the receptor and improved the sensing ability of the yeast cells for the odorant. Furthermore, the replacement of the endogenous yeast G‐protein α subunit (Gpa1) by the OR‐specific Golf drastically elevated the odorant‐sensing ability of the yeast cells and caused the cells to display a dose‐dependent responsiveness to the odorant. Because of the suitability of yeast cells for screening large‐scale libraries, the strategy presented here would be useful for the establishment of advanced biomimetic odor‐sensing systems. Biotechnol. Bioeng. 2012;109: 205–212. © 2011 Wiley Periodicals, Inc.
AIM and ELF Analyses of Halogen Bonding in NCS:BrCl Complexes
Authors: Li Xiaoyan , Sun Jie , Zhang Xueying , Zeng Yanli , Zheng Shijun , Meng Lingpeng 
Published: September 2011

AbstractThe nature of halogen bonding in five complexes formed between the thiocyanate (NCS) radical and a BrCl molecule was analyzed by quantum theory of atoms in molecules (QTAIM) and electron‐localization function (ELF) in this paper. The calculated results show that the geometry of the halogen atom bonded at the N‐atom is stable than those bonded at S‐ or C‐atom. The molecular electrostatic potentials determine the geometries and stabilities of the complexes. The valence basin of the S‐ or N‐atom in the electron‐donating NCS radical is compressed and its population decreases during the process of formation of the halogen‐bonded complexes.
Experimental determination of laws of color harmony. Part 6: Numerical index system of color harmony
Authors: Nemcsics Antal 
Published: September 2011

AbstractThe numerical index system of color harmony is intended to mark a great number of color pairs, optimally any number of existing color pairs, by a number between 0 and 100. This number expresses the extent to which a color pair is being felt harmonious by the average of people and the level of harmony content it possesses. The experiments described in this article have determined the basic data necessary to create this system. The series of the experiments have been done in two stages. The first stage, in which 24 test objects were presented to the experimental subjects, was carried out twice first in 1988–1990 and again in 2004–2006. Every test set was composed of eight compositions. The number of scores, given to each of the compositions, determined the harmony content of the color pair groups, whose members are formed from the saturated colors of different hues and from the members of the grey scale. In the second stage of the experiment, these data served as references for the experimental subjects. In the second stage, there were 192 tests. In these tests, there were different numbers of compositions each formed of different color pairs. One of the members of these color pairs was the member of the saturated color of the first experiment. The second member was always of different saturation and lightness for each of the compositions, purposefully chosen to match the saturated colors. Based on the experimental scores, we obtained a color harmony surface linked to the intersections with the coordinates in the Coloroid system. The color harmony surfaces and the distances between the related intersections indicate the harmony content of the color pair. The numerical values of these distances are called the color harmony index number of the color pair. These data make the creation of a color harmony indexing system possible, expressing the color harmony content of all possible color pairs, in the color space. © 2011 Wiley Periodicals, Inc. Col Res Appl, 2012
A new method for high speed, sensitive detection of minimal residual disease
Authors: Liu Xiaohe , Hsieh H. Ben , Campana Dario , Bruce Richard H. 
Published: September 2011

AbstractInvestigations of rare cell types in peripheral blood samples, such as tumor, fetal, and endothelial cells, represent an emerging field with several potentially valuable medical applications. Peripheral blood is a particularly attractive body fluid for the detection of rare cells as its collection is minimally invasive and can be repeated throughout the course of the disease. Because the number of rare cells in mononuclear cells can be very low (1 in 10 million), a large number of cells must be quickly screened, which places demanding requirements on the screening technology. While enrichment technology has shown promise in managing metastatic disease, enrichment can cause distortions of cell morphology that limit pathological identification, and the enrichment targeting adds additional constraints that can affect sensitivity. Here, we describe a new approach for detecting rare leukemia cells that does not require prior enrichment. We have developed an immunocytochemical assay for identification of leukemia cells spiked in peripheral blood samples, and a high‐speed scanning instrument with high numerical aperture and wide field of view to efficiently locate these cells in large sample sizes. A multiplex immunoassay with four biomarkers was used to uniquely identify the rare cells from leukocytes and labeling artifacts. The cytometer preserves the cell morphology and accurately locates labeled rare cells for subsequent high resolution imaging. The sensitivity and specificity of the approach show promise for detection of a low number of leukemia cells in blood (1 in 10 million nucleated cells). The method enables rapid location of rare circulating cells (25 M cells/min), no specific enrichment step, and excellent imaging of cellular morphology with multiple immunofluorescent markers. The cell imaging is comparable to other imaging approaches such as laser scan cytometry and image flow cytometry, but the cell analysis rate is many orders of magnitude faster making this approach practical for detection of rare cells. © 2011 International Society for Advancement of Cytometry
Scoring systems in mantle cell lymphoma: A critical point of view
Authors: Juncà Jordi , Ruiz‐Xivillé Neus , Granada Isabel , Rodríguez‐Hernández Inés , Navarro Josep‐Tomàs , Luis Mate José , Millá Fuensanta 
Published: September 2011

AbstractA proposal for a scoring system in the diagnosis of chronic lymphoproliferative diseases other than CLL has been recently published in Cytometry Part B. The authors apply this score for deciding whether or not FISH evaluation for the detection of IGH/CCND1 rearrangements must be performed to exclude Mantle Cell Lymphoma (MCL). In their validation series, no MCL scored <3. We have applied their system to our cases of MCL and also to a small series of Marginal Zone lymphomas. In our hands, the scoring system as has been published does not discriminate adequately between both entities. We propose using the negativity of a marker, CD11c, instead of the platelet count to improve the results. However, we believe that given the clinical and prognostic implications of the diagnosis of MCL, scoring systems should be greatly ameliorated prior to their generalized use. © 2011 International Clinical Cytometry Society
Energy‐aware geographic routing in wireless sensor networks with anchor nodes
Authors: Huang Haojun , Hu Guangmin , Yu Fucai 
Published: September 2011

SUMMARYEnergy efficiency has become an important design consideration in geographic routing protocols for wireless sensor networks because the sensor nodes are energy constrained and battery recharging is usually not feasible. However, numerous existing energy‐aware geographic routing protocols are energy‐inefficient when the detouring mode is involved in the routing. Furthermore, most of them rarely or at most implicitly take into account the energy efficiency in the advance. In this paper, we present a novel energy‐aware geographic routing (EAGR) protocol that attempts to minimize the energy consumption for end‐to‐end data delivery. EAGR adaptively uses an existing geographic routing protocol to find an anchor list based on the projection distance of nodes for guiding packet forwarding. Each node holding the message utilizes geographic information, the characteristics of energy consumption, and the metric of advanced energy cost to make forwarding decisions, and dynamically adjusts its transmission power to just reach the selected node. Simulation results demonstrate that our scheme exhibits higher energy efficiency, smaller end‐to‐end delay, and better packet delivery ratio compared to other geographic routing protocols. Copyright © 2011 John Wiley & Sons, Ltd.
Modular Construction of Fluorescent Lipophosphoramidates by Click Chemistry
Authors: Berchel Mathieu , Haelters Jean‐Pierre , Couthon‐Gourvès Hélène , Deschamps Laure , Midoux Patrick , Lehn Pierre , Jaffrès Paul‐Alain 
Published: September 2011

AbstractThe synthesis of fluorescent lipophosphoramidates is reported. Their modular construction allows several variations of the molecular structure including the separation of the fluorescent probe from the lipophosphoramidate moiety by a short methylene or by a tetraethylene glycol spacer. The last step of the convergent synthesis is a Huisgen click reaction, which assembles the fluorescent probe with the lipophosphoramidate part. Five fluorescent probes have been considered in this study including coumarin, NBD, fluorescein, naphthalimide and cyanine.
Fluvial response to an historic lowstand of the Great Salt Lake, Utah
Authors: Skorko Krysia , Jewell Paul W. , Nicoll Kathleen 
Published: September 2011

ABSTRACTUnderstanding fluvial adjustments to base level changes benefits the fields of sequence stratigraphy, geomorphology and petroleum geology. This investigation is a modern case study of the channel dynamics of Lee Creek and the Goggin Drain, two streams that are part of the Jordan River drainage into the endorheic Great Salt Lake of northern Utah, a lacustrine system that has experienced multiple, decadal‐scale base level changes. Since 1965, the lake level has fluctuated in elevation more than 6 m, transitioning from an historic lowstand [< 1279 m above sea level (a.s.l.)] to an historic highstand (>1284 m a.s.l.), and in 2009–2010 approaching an historic lowstand. This study uses detailed aerial images, fieldwork and LiDAR data to link the modern geomorphology and channel hydraulics to specific variations in sediment transport, channel form, and avulsion behavior. Although Lee Creek and the Goggin Drain are situated only a few kilometers apart and share similar shore zone gradients, substrates and vegetation patterns, and have been subjected to the same changes in lake level, their channel forms have evolved very differently. Differences in discharge patterns are likely the most influential factor causing the meandering form of Lee Creek and the braiding channel of the Goggin Drain. Despite the differences in discharge, total sediment eroded from the two streams is comparable and can be attributed to similar stream power/unit stream width in the two streams. Although Lee Creek has not recently been avulsive, three major avulsions of the Goggin Drain have taken place since 1965. Two possible styles of avulsion are interpreted: an allogenic response to changing base level, and an autogenic response dictated by channel morphology and hydraulics. Despite a wealth of available information, avulsions cannot be unequivocally attributed to one style or another. Caution should be used when attempting to link the complex process of avulsion to causal mechanisms. Copyright © 2011 John Wiley & Sons, Ltd.
Boulder deposition during major tsunami events
Authors: Costa Pedro J. M. , Andrade César , Freitas Maria C. , Oliveira Maria A. , da Silva Carlos M. , Omira Rachid , Taborda Rui , Baptista Maria A. , Dawson Alastair G. 
Published: September 2011

ABSTRACTA remarkable accumulation of marine boulders located above the present spring tide level has occurred in two coastal lowlands of the Algarve (Portugal). The size‐interval of the particles studied here is seldom reported in the literature in association with extreme events of coastal inundation, thus making this study of relevance to many other coasts worldwide. The spreads of boulders extend several hundred meters inland and well beyond the present landward limit of storm activity. The marine origin of the boulders is demonstrated by well‐developed macro‐bioerosion sculpturing and in situ skeletal remains of endolithic shallow marine bivalves. The good state preservation of the fossils within the boulders indicates that abrasion during transport and redeposition was not significant. We envisage boulder deposition as having taken place during the Lisbon tsunami of ad 1755 through the simultaneous landward entrainment of coarse particles from nearshore followed by rapid shoreward suspended‐dominated transport and non‐graded redeposition that excluded significant sorting by weight or boulder dimensions. We use numerical hydrodynamic modeling of tsunami (and storm) waves to test the observational data on boulder dimensions (density, size, distribution) on the most likely processes of sediment deposition. This work demonstrates the effectiveness of the study of boulder deposits in tsunami reconstruction. Copyright © 2011 John Wiley & Sons, Ltd.
Genetic variation of XPA gene and risk of cancer: A systematic review and pooled analysis
Authors: Ding Dapeng , Zhang Ying , Yu Hailang , Guo Yunbo , Jiang Ling , He Xiaofeng , Ma Wenli , Zheng Wenling 
Published: September 2011

AbstractXPA, a zinc‐finger DNA‐binding protein, play an important role in both global genome and transcription‐coupled repair pathways. XPA −4G>A polymorphism was identified in the 5′ noncoding region, located four nucleotides upstream of the ATG start codon. Previous studies have shown that this polymorphism may affect mRNA tertiary structure and stability and play a role in susceptibility to cancer. However, the results remained controversial. To derive a more precise estimation of association between this polymorphism and risk of different types of cancer, we performed a meta‐analysis based on 36 case–control or case–cohort studies, including a total of 11,700 cases and 15,033 controls. We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, no significantly elevated cancer risk was found in all genetic models when eligible studies were pooled into the meta‐analysis. In the stratified analyses, we found that individuals with A‐allele had a higher risk of lung cancer (AA versus GG: OR = 1.25, 95% CI = 1.09–1.43; recessive model: OR = 1.31, 95% CI = 1.16–1.48). When stratified by ethnicity, significantly elevated risks were observed among Asian populations (AA versus GG: OR = 1.31, 95% CI = 1.01–1.70; dominant model: OR = 1.14, 95% CI = 1.00–1.30). This meta‐analysis suggests that XPA −4G>A polymorphism is associated with increased lung cancer risk and may be a low‐penetrant risk factor in Asian ethnicity for cancer development.
Zooplankton Communities in the Shallow Lake Guiers (Senegal, West Africa)
Authors: Kâ Samba , Bouvy Marc , Sané Seyni , Ba Ngansoumana , Arfi Robert , Thiaw Omar Thiom , Pagano Marc 
Published: September 2011

AbstractSeasonal variations of zooplankton communities and their interactions with phytoplankton and environmental parameters were studied over a twelve‐month period in Lake Guiers (Senegal, West Africa). Zooplankton was most abundant during the warm and rainy season corresponding to the flood event (July to October) with peaks for rotifers and cyclopoid copepods in July–August and September–October, respectively. Filamentous cyanobacteria were the dominant phytoplankton during the warm season (August to November), while diatoms were dominant during the cool season (December to April). Temperature increase and river flooding both played an important role in these successions, favoring intense development of cyanobacteria and cyclopoid copepods. Trophic interactions also seem to be an important factor in structuring of the plankton community. Overall, the plankton composition displayed a trend toward a eutrophication state. Our study confirms the existence of seasonality in zooplankton communities and the importance of using biological indicators such as phyto‐ and zooplankton to monitor water quality, in particular in tropical freshwater ecosystems. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Collagen‐agarose co‐gels as a model for collagen–matrix interaction in soft tissues subjected to indentation
Authors: Lake Spencer P. , Hald Eric S. , Barocas Victor H. 
Published: September 2011

AbstractThe mechanical properties of soft tissues depend on the collagen fiber network and the surrounding non‐fibrillar matrix. The mechanical role of non‐fibrillar material remains poorly understood. Our recent study (Lake and Barocas, Ann Biomed Eng 2011) introduced collagen‐agarose co‐gels as a simple experimental model system to evaluate the mechanical contribution of non‐fibrillar matrix, and evaluated co‐gel properties in uniaxial tension. In this study, we utilized similar co‐gels to examine collagen‐matrix interaction in tissues subjected to incremental stress‐relaxation indentation tests. Mechanical testing was performed using two orthogonal custom test devices, and polarized light imaging was used to quantify 3D collagen fiber kinematics under load. The addition of agarose led to concentration‐dependent changes in the time‐dependent mechanical response and magnitude/spread of collagen fiber reorganization of tissue analogs. Specifically, peak/relaxed loads increased, and relaxation rate decreased, with increasing agarose concentration. In addition, increasing agarose content led to larger magnitude changes in orientation direction and alignment strength that were more localized near the indenter. Results suggest that non‐fibrillar material significantly contributes to the behavior of co‐gels in indentation, likely by reducing permeability and resisting volume change, thereby providing insight into the properties of artificial and native tissues subjected to non‐tensile loading. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 2011.
Electron Transfer in Metal‐Organic Molecules. A Time Resolved EXAFS and Optical Spectroscopy Study
Authors: Chen Jie , Chen Wei‐Kan , Rentzepis Peter M. 
Published: September 2011

AbstractWe have measured, by means of ultrafast x‐ray absorption and optical spectroscopy, the M‐O (M=Fe, Co) and Co‐N metal to ligand bond length change as a function of time and the formation and decay of the excited states and intermediate species, after excitation with a 267 nm femtosecond pulse. These experimental data combined with DFT calculations allowed us to determine the mechanism of electron transfer operating in the redox reaction of two metal‐ligand complexes, [M(III)(C2O4)3]3‐ and [Co(III)(NH3)6 ]3+. Based on the data we find that, even though both molecules are excited into their charge transfer band, the redox reaction of [M(III)(C2O4)3]3‐ proceeds via intermolecular electron transfer while [Co(III)(NH3)6 ]3+ electron transfer mechanism is intramolecular.
Metal Ion‐Assisted Infrared Optical Sensor for Selective Determination of Tryptophan in Urine Samples
Authors: Huang Genin Gary , Cheng Min‐Liang , Yang Jyisy 
Published: September 2011

AbstractIn this study, a simple infrared chemical sensor was developed for the selective detection of tryptophan in biological fluids. This sensor was capable of trapping tryptophan molecules through the formation of relatively stable metal ion complexes on the surface of the sensing element. A proline‐modified sensing phase was immobilized on the surface of the internal reflection element. With the assistance of appropriate metal ions, tryptophan molecules were selectively attracted nearby the evanescent field such that analytical signals were generated. Factors that affected the chemical equilibria in this detection system were examined including the species and concentration of metal ion, the pH of the sample solution, and the concentration of the chelating agent. Among the examined metal ions, nickel provided the best selectivity toward the detection of tryptophan as a result of its extremely high formation constant with tryptophan. Under the optimal conditions, the detected signals were related linearly (R2 > 0.99) to concentrations of tryptophan up to 600 μM. Based on three times the baseline variation of blank samples, the detection limit was ca. 5 μM. From a study of possible interfering agents—metal ions and organic species—in the sample solution, the recoveries of tryptophan were greater than 95%.