bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new robust correlation estimator for bivariate data
Authors: Shafiullah AZM , Khan Jafar A 
Published: May 2012

Key words: Outliers; robustness; iterative algoritm; computational efficiency; median productDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10766Bangladesh J. Sci. Res. 24(2):97-106, 2011 (December)
Voltammetric studies of the interaction of copper(II) with melamine in Britton-Robinson buffer solution
Authors: Badrunnessa AA Shaikh , Rahman MS , Pasha NA , Baksi Pradip K 
Published: May 2012

Key words: Britton-Robinson buffer; cyclic voltammetry; copper(II); melamine; glassy carbon electrodeDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10767Bangladesh J. Sci. Res. 24(2):107-116, 2011 (December)
Information retrieval with text mining for Decision Support System
Authors: Rahman Mahmuda 
Published: May 2012

Key words: Natural language processing; C4.5 classification; DSS, machine learning; KNN clustering; SVMDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10768 Bangladesh J. Sci. Res. 24(2):117-126, 2011 (December)
Effect of organic manures on growth, yield and nutrient uptake in maize
Authors: Haque Md Sarwarul , Solaiman ARM , Karim AJM Sirajul , Rahman GKM Mustafizur , Karim Md Abdul 
Published: May 2012

Key words: Organic manures; growth; yield; nutrient uptake; maizeDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10770 Bangladesh J. Sci. Res. 24(2):135-144, 2011 (December)
Factors associated with child health in urban areas of Bangladesh
Authors: Uddin M Sheikh Giash , Hosain M Mozaffar 
Published: May 2012

Key words: Infant mortality; health seeking behaviour; urban areaDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10772 Bangladesh J. Sci. Res. 24(2):145-154, 2011 (December)
Effect of nutrient solution on quality of okra
Authors: Rahman Md Atikur , Solaiman ARM , Rahman GKM Mustafizur 
Published: May 2012

Key words: Nutrient solution; quality; okraDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10773 Bangladesh J. Sci. Res. 24(2):155-160, 2011 (December)
Yield of rice and its mineral contents as influenced by sewage sludge and nitrogen
Authors: Kabir MK , Kamal ATMM , Jahan S , Faizullah AMM , Ullah SM 
Published: May 2012

Key words: Sewage sludge; Nitrogen fertilization; Rice grain yield; Mineral contentsDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10774 Bangladesh J. Sci. Res. 24(2):161-168, 2011 (December)
Effect of waste glass powder on physico-mechanical properties of ceramic tiles
Authors: Mustafi Sonjida , Ahsan Mainul , Dewan A Hamid , Ahmed Samina , Khatun Nazia , Absar Nurul 
Published: May 2012

Key words: Ceramic tile; water absorption; bulk density; firing shrinkage; modulus of ruptureDOI: http://dx.doi.org/10.3329/bjsr.v24i2.10775 Bangladesh J. Sci. Res. 24(2):169-180, 2011 (December)
New insights into scaling of fat‐free mass to height across children and adults
Authors: Wang Zimian , Zhang Junyi , Ying Zhiliang , Heymsfield Steven B. 
Published: May 2012

AbstractObjective:Forbes expressed fat‐free mass (FFM, in kg) as the cube of height (H, in m): FFM = 10.3 × H3. Our objective is to examine the potential influence of gender and population ancestry on the association between FFM and height.Methods:This is a cross‐sectional analysis involving an existing dataset of 279 healthy subjects (155 males and 124 females) with age 5–59 years and body mass index (BMI) 14–28 kg/m2. FFM was measured by a four‐component model as the criterion.Results:Nonlinear regression models were fitted: FFM = 10.8 × H2.95 for the males and FFM = 10.1 × H2.90 for the females. The 95% confidence intervals for the exponential coefficients were (2.83, 3.07) for the males and (2.72, 3.08) for the females, both containing hypothesized value 3.0. Population ancestry adjustment was considered in the H‐FFM model. The coefficient of the H‐FFM model for male Asians is smaller than that for male Caucasians (P = 0.006), while there is no statistically significant difference among African‐Americans, Caucasians and Hispanics: 10.6 for the males (10.1 for Asians, 10.8 for African‐Americans, 10.7 for Caucasians and 10.4 for Hispanics) and 9.6 for the females (9.3 for Asians, 9.8 for African‐Americans, 9.6 for Caucasians and 9.5 for Hispanics). Age adjustment was unnecessary for the coefficient of the H‐FFM model.Conclusion:Height is the most important factor contributing to the magnitude of FFM across most of the lifespan, though both gender and ancestry effects are significant in the H‐FFM model. The proposed H‐FFM model can be further used to develop a mechanistic model to explain why population ancestry, gender and age influence the associations between BMI and %Fat. Am. J. Hum. Biol., 2012. © 2012 Wiley Periodicals, Inc.
Influence of body fat and level of physical activity on rate‐pressure product at rest in preschool children
Authors: Mota Jorge , Soares‐Miranda Luísa , Silva Joana Maia E , Dos Santos Sandra Silva , Vale Susana 
Published: May 2012

AbstractObjective:The rate‐pressure product (RPP) has strong correlation with the maximal oxygen consumption and is an indicator of myocardium stress being considered as the best indirect method to measure myocardial oxygen consumption. However, to the best of our knowledge, no studies have addressed in preschool children. The aim of this study was to analyze the influence of percentage of body fat (%BF) and physical activity (PA) patterns on RPP at Rest (RPPrest) as a marker of cardiac load in Preschool children.Methods:The study comprised 593 preschool children aged 3–6 years‐old. Heart rate (HR), systolic (SBP), and diastolic (DBP) blood pressure were taken at rest. The RPP was then calculated. The %BF was estimated from four skinfolds thicknesses and PA was assessed during 7 consecutive days by accelerometry.Results:Our data showed that only %BF (P ≤ 0.001) and vigorous PA (P ≤ 0.05) contributed significantly toward RPPrest variation. However, the multivariate analysis showed that only %BF (P ≤ 0.05) had a significant influence on RPPrest variation.Conclusion:These findings suggest that on preschoolers there is an association between RPP at rest and %BF.Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.
Analysis of variability of high sensitivity C‐reactive protein in lowland ecuador reveals no evidence of chronic low‐grade inflammation
Authors: Mcdade Thomas W. , Tallman Paula S. , Madimenos Felicia C. , Liebert Melissa A. , Cepon Tara J. , Sugiyama Lawrence S. , Snodgrass James Josh 
Published: May 2012

AbstractObjectives:C‐reactive protein (CRP) is a central component of innate immune defenses, and high sensitivity CRP has emerged as an important biomarker of chronic inflammation and cardiovascular disease risk. Prior analyses of CRP variability have reported stable between‐individual differences in CRP over time, but a limitation of current knowledge is that it is based on research conducted in post‐epidemiologic transition populations.Methods:This study evaluated CRP variability among adults in the southeastern region of the Ecuadorian Amazon where rates of infectious diseases remain high. Blood samples were collected from 52 adults at four weekly sampling intervals and were quantified using a high‐sensitivity immunoassay.Results:Median CRP concentration was 0.52 mg/l. About 34.6% of participants had CRP >3 mg/l at one time point, but no individuals had CRP >3 mg/l across two or more sampling intervals, and within‐individual correlations revealed low levels of stable, between‐individual differences in CRP. The application of current guidelines for the assessment of chronic inflammation failed to detect a single case of “high risk” CRP.Conclusions:This study is the first to investigate CRP variability in a nonindustrialized, high infectious disease environment. It documents a pattern of variation over time that is distinct from prior research, with no evidence for chronic low‐grade inflammation. These results may have substantial implications for research on inflammation and diseases of aging globally, as well as for scientific understandings of the regulation of inflammation. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.
Acrylic hydrogels‐based biocomposites: Synthesis and characterization
Authors: Sandu Teodor , Sârbu Andrei , Constantin Floriana , Vulpe Silviu , Iovu Horia 
Published: May 2012

AbstractHydrogels based on polyacrylic and polymethacrylic acids were synthesized using two variants of redox initiating systems and three crosslinking agents in various ratios to the monomer. The chemical structure of these hydrogels was extensively studied by Fourier transform infrared (FTIR) spectrometry and Raman spectrometry. These hydrogels were also characterized by other techniques, namely thermo gravimetric analysis (TGA), differential thermal gravimetry, differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). The hydrogel ability to immobilize enzymes through covalent bonds was studied by FTIR and Raman spectrometry and by analyzing the SEM images before and after enzyme immobilization. The enzyme influence on the thermal behavior of the hydrogel biocomposite was investigated by DSC and TGA, too. The methacrylic acid leads to more thermo stable hydrogels formation than acrylic acid. Acrylic and methacrylic hydrogels are able to covalently immobilize enzymes. This is proved by the important changes which occur in the chemical composition, the thermal behavior and the morphology of hydrogels after immobilization stage. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Mechanical properties of epoxy composites with low content of diamond particles
Authors: Rakha Sobia A. , Khan Ramsha R. , Khurram Aqeel A. , Fayyaz A. , Zakaullah M. , Munir Arshad 
Published: May 2012

AbstractDiamond‐epoxy composites reinforced with low content of submicron diamond powder 0.1, 0.4, 0.7, and 1.0 wt % were synthesized. As received diamond powder was acid treated to purify and functionalize diamond particles. Fourier Transform Infrared Spectroscopy was utilized to study the moieties attached to the diamond particles. The trace elemental analysis of impurities in diamond powder before and after acid treatment was performed using ion beam techniques. The mechanical properties of the epoxy matrix were enhanced with the addition of purified and functionalized diamond powder. The Dynamical mechanical analysis results revealed that storage modulus of the prepared composites has been increased by ∼ 100% with diamond loading of 0.7 wt %. The Vickers's hardness of the diamond‐epoxy composite was ∼ 39% higher than that of pure epoxy for the loading of 1.0 wt % diamond powder. Mechanisms responsible for the enhancement of the mechanical properties are discussed. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Dichrometer Errors Resulting from Large Signals or Improper Modulator Phasing
Authors: Sutherland John C. 
Published: May 2012

ABSTRACTA single‐beam spectrometer equipped with a photoelastic modulator can be configured to measure a number of different parameters useful in characterizing chemical and biochemical materials including natural and magnetic circular dichroism, linear dichroism, natural and magnetic fluorescence‐detected circular dichroism, and fluorescence polarization anisotropy as well as total absorption and fluorescence. The derivations of the mathematical expressions used to extract these parameters from ultraviolet, visible, and near‐infrared light‐induced electronic signals in a dichrometer assume that the dichroic signals are sufficiently small that certain mathematical approximations will not introduce significant errors. This article quantifies errors resulting from these assumptions as a function of the magnitude of the dichroic signals. In the case of linear dichroism, improper modulator programming can result in errors greater than those resulting from the assumption of small signal size, whereas for fluorescence polarization anisotropy, improper modulator phase alone gives incorrect results. Modulator phase can also impact the values of total absorbance recorded simultaneously with linear dichroism and total fluorescence. Chirality 24:706–717, 2012. © 2012 Wiley Periodicals, Inc.†
β‐arrestin 2‐dependent activation of ERK1/2 is required for ADP‐induced paxillin phosphorylation at Ser83 and microglia chemotaxis
Authors: Lee Sang‐Hyun , Hollingsworth Ryan , Kwon Hyeok‐Yil , Lee Narae , Chung Chang Y. 
Published: May 2012

AbstractMicroglia play crucial roles in increased inflammation in the central nervous system upon brain injuries and diseases. Extracellular ADP has been reported to induce microglia chemotaxis and membrane ruffle formation through P2Y12 receptor. In this study, we examined the role of ERK1/2 activation in ADP‐induced microglia chemotaxis. ADP stimulation increases the phosphorylation of extracellular signal‐regulated kinase 1/2 (ERK1/2) and paxillin phosphorylation at Tyr31 and Ser83. Inhibition of ERK1/2 significantly inhibited paxillin phosphorylation at Ser83 and the retraction of membrane ruffles, causing inefficient chemotaxis. Close examination of dynamics of focal adhesion (FA) formation with green fluorescent protein‐paxillin revealed that the disassembly of FAs in U0126‐treated cells was significantly impaired. Depletion of β‐Arrestin 2 (β‐Arr2) with short hairpin RNA markedly reduced the phosphorylation of ERK1/2 and Pax/Ser83, indicating that β‐Arr2 is required for ERK1/2 activation upon ADP stimulation. A large fraction of phosphorylated ERK1/2 and β‐Arr2 were translocated and co‐localized at focal contacts in the newly forming lamellipodia. Examination of kinetics and rate constant of paxillin formation and disassembly revealed that the phosphorylation of paxillin at Tyr31 by c‐Src appears to be involved in adhesion formation upon ADP stimulation while Ser83 required for adhesion disassembly. © 2012 Wiley Periodicals, Inc.
Fingolimod—A sphingosine‐like molecule inhibits vesicle mobility and secretion in astrocytes
Authors: Trkov Saša , Stenovec Matjaž , Kreft Marko , Potokar Maja , Parpura Vladimir , Davletov Bazbek , Zorec Robert 
Published: May 2012

AbstractIn the brain, astrocytes signal to the neighboring cells by the release of chemical messengers (gliotransmitters) via regulated exocytosis. Recent studies uncovered a potential role of signaling lipids in modulation of exocytosis. Hence, we investigated whether sphingosine and the structural analog fingolimod/FTY720, a recently introduced therapeutic for multiple sclerosis, affect (i) intracellular vesicle mobility and (ii) vesicle cargo discharge from cultured rat astrocytes. Distinct types of vesicles, peptidergic, glutamatergic, and endosomes/lysosomes, were fluorescently prelabeled by cell transfection with plasmids encoding atrial natriuretic peptide tagged with mutant green fluorescent protein and vesicular glutamate transporter tagged with enhanced green fluorescent protein or by LysoTracker staining, respectively. The confocal and total internal reflection fluorescence microscopies were used to monitor vesicle mobility in the cytoplasm and near the basal plasma membrane, respectively. Sphingosine and FTY720, but not the membrane impermeable lipid analogs, dose‐dependently attenuated vesicle mobility in the subcellular regions studied, and significantly inhibited stimulated exocytotic peptide and glutamate release. We conclude that in astrocytes, cell permeable sphingosine‐like lipids affect regulated exocytosis by attenuating vesicle mobility, thereby preventing effective vesicle access/interaction with the plasma membrane docking/release sites. © 2012 Wiley Periodicals, Inc.
Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation
Authors: Niu Jianqin , Mei Feng , Wang Lingyun , Liu Shubao , Tian Yanping , Mo Wei , Li Hongli , Lu Q. Richard , Xiao Lan 
Published: May 2012

AbstractOligodendroglial cells undergo rapid transcriptional and dynamic morphological transformation in order to effectively myelinate neuronal axons. Olig1, a basic helix‐loop‐helix transcription factor, functions to promote the transcription of myelin‐specific genes and promotes differentiation and (re)myelination. While the role for nuclear Olig1 is well established, the function for cytoplasmic Olig1 remains uncertain. We observe that translocation of Olig1 into the cytosol highly correlates with differentiation of oligodendrocytes both invivo and invitro. By enforcing expression of a nuclear‐specific form of Olig1 into OPCs in a null‐Olig1 background, we demonstrate that nuclear Olig1 is sufficient to facilitate MBP expression, but with greatly diminished membrane volume and area. We demonstrate that serine 138 in the helix‐loop‐helix domain of Olig1 is phosphorylated and that this form resides in the cytosol. Mutating serine 138 to alanine restricts Olig1 to the nucleus, facilitating MBP expression but limiting membrane expansion. However, a serine to aspartic acid mutation results in the cytoplasmic localization of Olig1 enhancing membrane expansion. Our results suggest a novel role for a phosphorylated cytosolic Olig1 in membrane expansion and maturation of oligodendrocytes. © 2012 Wiley Periodicals, Inc.
Simulating magnetohydrodynamic natural convection flow in a horizontal cylindrical annulus using the lattice Boltzmann method
Authors: Ashorynejad Hamid Reza , Sedighi Kurosh , Farhadi Mousa , Fattahi Ehsan 
Published: May 2012

AbstractA numerical study is presented about the effect of a uniform magnetic field on free convection in a horizontal cylindrical annulus using the lattice Boltzmann method. The inner and outer cylinders are maintained at uniform temperatures and it is assumed the walls are insulating with a magnetic field. Detailed numerical results of heat transfer rate, temperature, and velocity fields have been presented for Pr=0.7, Ra=103 to 5 × 104, and Ha=0 to 100. The computational results show that in a horizontal cylindrical annulus the flow and heat transfer are suppressed more effectively by a radial magnetic field. It is also found that the flow oscillations can be suppressed effectively by imposing an external radial magnetic field. The average Nusselt number increases by increasing the radius ratio while it decreases by increasing the Hartmann number. © 2012 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21008
Long‐term follow‐up of cancer patients treated with gene therapy medicinal products
Authors: Galli Maria Cristina 
Published: May 2012

AbstractEuropean Union requirements are discussed for the long‐term follow‐up of advanced therapy medicinal products, as well as how they can be applied to cancer patients treated with gene therapy medicinal products in the context of clinical trials, as described in a specific guideline issued by Gene Therapy Working Party at the European Medicine Agency. Copyright © 2012 John Wiley & Sons, Ltd.
Surface-modified cobalt oxide nanoparticles: new opportunities for anti-cancer drug development
Authors: Chattopadhyay S. , Chakraborty S. P. , Laha D. , Baral R. , Pramanik P. , Roy S. 
Published: May 2012

Abstract
The development of smart nanoparticles that can exhibit the anti-cancer activity, introduces better efficacy and lower toxicity for treatment. The present study was aimed to evaluate the anti-cancer activity of surface functionalized CoO nanoparticles against Jurkat (T-cell lymphoma) and KB (oral carcinoma) cell lines. The nano-sized cobalt oxide nanoparticles (CoO) was prepared by thermal decomposition method followed by surface modification using phosphonomethyl iminodiacetic acid (PMIDA). The PMIDA-coated CoO nanoparticle was characterized by X-ray diffraction, dynamic light scattering, and transmission electron microscopy; and the conjugation was analyzed by Fourier transform infrared spectroscopy. The resultant nanoparticles with an average size less than 100 nm measured by dynamic light scattering and transmission electron microscopy. Cytotoxicity study, flow cytometric analysis and scanning electron micrographs have been revealed that PMIDA-coated nanoparticles significantly enhances the cellular uptake of the nanoparticle and thus facilitates apoptosis of cancer cell (Jurkat and KB). For the application of PMIDA-coated CoO nanoparticles in the medical field, doxorubicin, a potent anti-cancer drug, has been used in similar fashion in this experimental design and all these effects or patterns were observed.
Functional modulation of a protein folding landscape via side-chain distortion
Authors: Kelch Brian A. , Salimi Neema L. , Agard David A. 
Published: May 2012

Ultrahigh-resolution (< 1.0
Å
) structures have revealed unprecedented and unexpected details of molecular geometry, such as the deformation of aromatic rings from planarity. However, the functional utility of such energetically costly strain is unknown. The 0.83 Å structure of α-lytic protease (αLP) indicated that residues surrounding a conserved Phe side-chain dictate a rotamer which results in a ∼6° distortion along the side-chain, estimated to cost 4 kcal/mol. By contrast, in the closely related protease Streptomyces griseus Protease B (SGPB), the equivalent Phe adopts a different rotamer and is undistorted. Here, we report that the αLP Phe side-chain distortion is both functional and conserved in proteases with large pro regions. Sequence analysis of the αLP serine protease family reveals a bifurcation separating those sequences expected to induce distortion and those that would not, which correlates with the extent of kinetic stability. Structural and folding kinetics analyses of family members suggest that distortion of this side-chain plays a role in increasing kinetic stability within the αLP family members that use a large Pro region. Additionally, structural and kinetic folding studies of mutants demonstrate that strain alters the folding free energy landscape by destabilizing the transition state (TS) relative to the native state (N). Although side-chain distortion comes at a cost of foldability, it suppresses the rate of unfolding, thereby enhancing kinetic stability and increasing protein longevity under harsh extracellular conditions. This ability of a structural distortion to enhance function is unlikely to be unique to αLP family members and may be relevant in other proteins exhibiting side-chain distortions.
Escapement of eel (Anguilla anguilla) in coastal areas in Sweden over a 50-year period
Authors: Andersson Jan , Florin Ann-Britt , Petersson Erik 
Published: May 2012

Abstract
Andersson, J., Florin, A.-B., and Petersson, E. 2012. Escapement of eel (Anguilla anguilla) in coastal areas in Sweden over a 50-year period – ICES Journal of Marine Science, 69: 991–999. The escapement of eel from coastal areas in Sweden during the last 50 years was assessed using data from voluntary fishery journals and fishery-independent coastal fish monitoring programmes. It was evident that the level of escapement, determined as catch per unit of effort in numbers, from the Baltic Sea decreased over time, with the most rapid decline occurring in the 1960s and early 1970s, but also in recent years. There were, however, differences in the temporal variability in escapement between areas. Escapement from the northernmost studied site did not change significantly during the last 50 years, while there was a rapid decline in the southern areas. Escapement remained relatively stable between the late 1970s and 2000 however, and escapement at the Swedish west coast, inferred from yellow eel catch per unit of effort, generally increased during the same time. The loss in numbers has to some extent been compensated by an increase in mean weight of silver eel. Possible explanations for the retained level of escapement during the last decades despite the continued reduction in recruitment are discussed. Favourable environmental conditions in combination with a lower fishing effort are suggested as the most probable reasons why the escapement decline has not been more dramatic, but stocking and density-dependent effects cannot be ruled out.