bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of the outcome of percutaneous nerve evaluation for faecal incontinence
Authors: Maeda Y , Norton C , Lundby L , Buntzen S , Laurberg S 
Published: April 2010

Abstract

Background
The aim was to identify patient-related and operative factors that might predict the outcome of percutaneous nerve evaluation (PNE).

Methods
Demographic data (age, sex, body mass index), primary cause of incontinence, number and type of incontinence episodes, results of endoanal ultrasonography and manometry, and operative factors from 244 patients who underwent PNE for faecal incontinence were reviewed. Each factor was assessed according to the outcome, and explored by univariable and multivariable analysis to identify predictors.

Results
Some 191 patients (78·3 per cent) had a successful PNE. A low amplitude of sensory threshold during PNE (odds ratio (OR) 0·69 (95 per cent confidence interval 0·59 to 0·81); P &lt; 0·001) and lead placement anterior to the sacral cortex (OR 9·06 (4·70 to 17·45); P &lt; 0·001) were positive predictive factors for successful outcome of PNE. Neither a defect nor an abnormality of either the external (OR 0·88 (0·39 to 1·97); P = 0·749) or internal (OR 0·62 (0·27 to 1·42); P = 0·255) anal sphincter was a negative predictive factor. Demographic variables, number of incontinence episodes and the motor response threshold did not predict outcome.

Conclusion
No preoperative predictor of PNE outcome could be identified. Predictors were limited to operative lead placement and sensory response during PNE.
Anatomy in ancient China: The Yellow Emperor's Inner Canon of Medicine and Wang Qingren's Correcting the Errors in the Forest of Medicine
Authors: Loukas Marios , Ferrauiola Julie , Shoja Mohammadali M. , Tubbs R. Shane , Cohen‐Gadol Aaron A. 
Published: April 2010

AbstractAlthough clouded by mysticism and ancestral worship, early Chinese civilization did make many important and often overlooked contributions to our current understanding of human anatomy. This article reviews these early contributions and focuses on the landmark writings of two of the most influential Chinese texts, the Huang Di Nei Jing (The Yellow Emperor's Inner Canon of Medicine) attributed to Huang di, and Wang Qingren's Yi Lin Gai Cuo (Correcting the Errors in the Forest of Medicine). These sources made significant contributions to the Chinese understanding of anatomy and served to promote the study of human anatomy both in early China and in regional countries like Japan. Clin. Anat. 23:364–369, 2010. © 2010 Wiley‐Liss, Inc.
Innervation of the supinator muscle and its relationship to two‐incision distal biceps tendon repair: An anatomic study
Authors: Duquin Thomas R. , Chavan Prithviraj R. , Bisson Leslie J. 
Published: April 2010

AbstractReinsertion of the ruptured distal biceps tendon has been performed using either a single‐anterior incision or a two‐incision approach. A systematic review of these two repair methods has identified a higher incidence of supination weakness following the two‐incision approach. The objective of this study was to describe the innervation of the supinator muscle and its implications regarding a two‐incision distal biceps repair. Twelve fresh upper extremity specimens from 12 males were dissected with the forearm in full pronation. The number of branches of the posterior interosseous nerve (PIN) to the supinator, their site of exit from the PIN trunk, and their distance from a variety of known anatomic landmarks were recorded. Specimens were characterized as high (<5 mm), moderate (6–10 mm), or low (>10 mm) risk of nerve branch injury depending on the proximity of nerve branches to the bicipital tuberosity. In general, we found the innervation of the supinator to be highly variable. There were from two to nine branches of the PIN which supplied the supinator, with 0–3 arising from the ulnar side of the nerve. Four specimens were at low, five at moderate, and three at high risk of nerve branch injury during dorsal exposure of the bicipital tuberosity. We conclude that there is a substantial amount of variability in the innervation of the supinator, with certain patterns being at higher risk of nerve branch injury if dissection of the supinator is carried out over the bicipital tuberosity. Clin. Anat. 23:413–419, 2010. © 2010 Wiley‐Liss, Inc.
Localization of the supraorbital, infraorbital, and mental foramina using palpable, bony landmarks
Authors: Smith Joshua D. , Surek Christopher C. , Cortez Edwin A. 
Published: April 2010

AbstractThe original article to which this Withdrawal refers was published online in the Clinical Anatomy
EarlyView section with Digital Object Identifier 10.1002/ca.20923.Withdrawal: The original article from Clinical Anatomy, "Localization of the Supraorbital, Infraorbital,
and Mental Foramina Using Palpable, Bony Landmarks" by Joshua D. Smith, Christopher C. Surek, and Edwin
A. Cortez, has been withdrawn by agreement between the authors, the journal's Editor‐in‐Chief and Wiley‐
Liss. The article has been withdrawn because permission to publish the patient's photos was not obtained
from the patient/family prior to publication.
Exercise prevents the effects of experimental arthritis on the metabolism and function of immune cells
Authors: Navarro Francisco , Bacurau Aline V. N. , Almeida Sandro S. , Barros Carlos C. , Moraes Milton R. , Pesquero Jorge L. , Ribeiro Sandra M. L. , Araújo Ronaldo C. , Costa Rosa Luis F. B. P. , Bacurau Reury F. P. 
Published: April 2010

AbstractActive lymphocytes (LY) and macrophages (MΦ) are involved in the pathophysiology of rheumatoid arthritis (RA). Due to its anti‐inflammatory effect, physical exercise may be beneficial in RA by acting on the immune system (IS). Thus, female Wistar rats with type II collagen‐induced arthritis (CIA) were submitted to swimming training (6 weeks, 5 days/week, 60 min/day) and some biochemical and immune parameters, such as the metabolism of glucose and glutamine and function of LY and MΦ, were evaluated. In addition, plasma levels of some hormones and of interleukin‐2 (IL‐2) were also determined. Results demonstrate that CIA increased lymphocyte proliferation (1.9‐ and 1.7‐fold, respectively, in response to concanavalin A (ConA) and lipopolysaccharide (LPS)), as well as macrophage H2O2 production (1.6‐fold), in comparison to control. Exercise training prevented the activation of immune cells, induced by CIA, and established a pattern of substrate utilization similar to that described as normal for these cells. Exercise also promoted an elevation of plasma levels of corticosterone (22.2%), progesterone (1.7‐fold) and IL‐2 (2.6‐fold). Our data suggest that chronic exercise is able to counterbalance the effects of CIA on cells of the IS, reinforcing the proposal that the benefits of exercise may not be restricted to aerobic capacity and/or strength improvement. Copyright © 2010 John Wiley & Sons, Ltd.
Analysis of transforming growth factor beta 1 (TGF‐β1) gene polymorphisms in Turkish patients with scleroderma
Authors: Büyük U , Ates Ö , Dalyan L , Müsellim B , Öngen G , Topal‐Sarıkaya A 
Published: April 2010

AbstractSystemic sclerosis (SSc) is an autoimmune disease characterized by inflammation and fibrosis of the skin and visceral organs. Fibrosis associated with SSc is characterized by an increased synthesis of a wide range of extracellular matrix (ECM). TGF‐β is a pluripotent cytokine in a wide range of cell types. In particular it has been found to be a potent inducer of ECM protein synthesis and fibroblast migration. The TGF‐β1 gene is highly polymorphic and two signal sequence polymorphisms at codon 10 and codon 25 are linked to disease outcomes. In this study, we analysed two polymorphic sites of the TGF‐β1 gene, codon 10 and codon 25, in 43 Turkish SSc female patients with interstitial lung involvement and in 75 healty individuals by ARMS‐PCR. In our study no significant difference was found in codon 10, codon 25 genotype frequencies between patient with SSc and the control group (p = 0.676, 0.375, respectively). Our findings suggest that codon 10 and 25 polymorphism cannot be related with SSc for Turkish population. Copyright © 2010 John Wiley & Sons, Ltd.
Response surfaces, desirabilities and rational functions in optimizing sugar production
Authors: Taavitsainen Veli‐Matti , Lehtovaara Anssi , Lähteenmäki Mira 
Published: April 2010

AbstractResponse surface methods have long been use in various chemical applications, most typically in optimization problems. Very often the problem, in addition to several design variables, has also several response variables to be optimized. A plethora of different approaches to multi‐response optimization exists but, in terms of simplicity, it is difficult to beat the desirability function technique. In spite of its simplicity and efficiency, the desirability function technique seems not to be familiar for all chemometricians. This case study of optimizing full‐scale sugar production will show how desirability functions were successfully used in response surface modeling (RSM)‐based optimization. The optimization was based on ordinary least‐squares regression polynomials. In addition to ordinary polynomial modeling, a new method of using rational functions, a linearizing transform and ridge regression is also introduced and discussed. In this study, a freeware computer program, R, for implementing response surface and desirability function methods is used. R plays the same de‐facto standard role among statisticians as perhaps does Matlab among chemometricians. R is already used by some chemometricians and contains some chemometrics or chemometrics‐related packages (R‐packages are analogous to Matlab toolboxes). This study illustrates the use of some common RSM tools and desirability functions. Copyright © 2010 John Wiley & Sons, Ltd.
Multiple response optimization: a global criterion‐based method
Authors: Costa Nuno Ricardo , Pereira Zulema Lopes 
Published: April 2010

AbstractProcesses and products have by nature many quality characteristics that must be in some sense optimized simultaneously. With this aim, a method which can be used easily and efficiently by practitioners for optimizing multi‐response problems is proposed. Implementation steps and considerations, in addition to optimization measures to assess method's solutions and guide the analyst in finding an effective compromise solution, are also presented. Three classical examples from the literature are used to assess the performance of several prominent methods in the response surface methodology (RSM) framework and help practitioners make a better‐informed choice among them. Copyright © 2010 John Wiley & Sons, Ltd.
e‐WOM Scale: word‐of‐mouth measurement scale for e‐services context
Authors: Goyette Isabelle , Ricard Line , Bergeron Jasmin , Marticotte François 
Published: April 2010

AbstractIn this article, using data from a survey of 218 consumers across two samples, we propose a measurement scale for word of mouth (e‐WOM scale) in the context of electronic service. A battery of statistical tests reveals that the WOM construct encompasses four dimensions: WOM intensity, positive valence WOM, negative valence WOM, and WOM content. Our proposed e‐WOM scale can be used as a strategic tool for business managers aiming to improve their word‐of‐mouth marketing strategies. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
The impact of e‐information on residential real estate services: transaction costs, social embeddedness, and market conditions
Authors: Saber Jane Lee , Messinger Paul R. 
Published: April 2010

AbstractThis paper examines the possibility of disintermediation of residential real estate agents arising from increased customer access to property information on the Internet (e‐information). The transaction cost viewpoint suggests that since customers now have ready access to e‐information without an agent, customer‐perceived value of agents and agent usage will decline. The social embeddedness perspective, by contrast, suggests that these changes are unlikely because the added value of agents goes beyond mere information aggregation and includes essential transaction activities that are embedded in social networks. A survey of buyers and sellers of real estate in Alberta provides partial support for the transaction cost viewpoint. However, buyers and sellers respond differently to market conditions (slow versus hot markets) in their proclivities to use real estate agents. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
Synthesis and in vitro Anticancer Activity of Octahedral Platinum(IV) Complexes with Cyclohexyl‐Functionalized Ethylenediamine‐N,N′‐Diacetate‐Type Ligands
Authors: Lazić Jelena M. , Vučićević Ljubica , Grgurić‐Šipka Sanja , Janjetović Kristina , Kaluđerović Goran N. , Misirkić Maja , Gruden‐Pavlović Maja , Popadić Dušan , Paschke Reinhard , Trajković Vladimir , Sabo Tibor J. 
Published: April 2010

AbstractThe present study describes the synthesis and anticancer activity of novel octahedral PtIV complexes with cyclohexyl functionalized ethylenediamine‐N,N′‐diacetate‐type ligands. Molecular mechanics calculations and density functional theory analysis revealed that s‐cis is the preferred geometry of these PtIV complexes with tetradentate‐coordinated (S,S)‐ethylenediamine‐N,N′‐di‐2‐(3‐cyclohexyl)propanoate. The viability of cancer cell lines (U251 human glioma, C6 rat glioma, L929 mouse fibrosarcoma, and B16 human melanoma) was assessed by measuring mitochondrial dehydrogenase activity and lactate dehydrogenase release. Cell‐cycle distribution, oxidative stress, caspase activation, and induction of autophagy were analyzed by flow cytometry using appropriate fluorescent reporter dyes. The cytotoxic activity of novel PtIV complexes against various cancer cell lines (IC50 range: 1.9–8.7 μM) was higher than that of cisplatin (IC50 range: 10.9–67.0 μM) and proceeded through completely different mechanisms. Cisplatin induced caspase‐dependent apoptosis associated with the cytoprotective autophagic response. In contrast, the new PtIV complexes caused rapid, caspase‐independent, oxidative stress‐mediated non‐apoptotic cell death characterized by massive cytoplasmic vacuolization, cell membrane damage, and the absence of protective autophagy.
A Series of18F‐Labelled Pyridinylphenyl Amides as Subtype‐Selective Radioligands for the Dopamine D3 Receptor
Authors: Hocke Carsten , Maschauer Simone , Hübner Harald , Löber Stefan , Utz Wolfgang , Kuwert Torsten , Gmeiner Peter , Prante Olaf 
Published: April 2010

AbstractSynthesis, biological activity, and structure–selectivity relationship (SSR) studies of a novel series of potential dopamine D3 receptor radioligands as imaging agents for positron emission tomography (PET) are reported. Considering a structurally diverse library of D3 ligands, SSR studies were performed for a new series of fluorinated pyridinylphenyl amides using CoMFA and CoMSIA methods. The in vitro D3 affinities of the predicted series of biphenyl amide ligands9 a–drevealed single‐digit to sub‐nanomolar potencies (Ki=0.52–1.6 nM), displaying excellent D3 selectivity over the D2 subtype of 110‐ to 210‐fold for the test compounds9 a–c. Radiofluorination by nucleophilic substitution of Br or NO2by18F led to radiochemical yields of 66–92 % for [18F]9 a–d. However, the specific activities of [18F]9 band [18F]9 dwere insufficient, rendering their use for in vivo studies impossible. Biodistribution studies of [18F]9 aand [18F]9 cusing rat brain autoradiography revealed accumulation in the ventricles, thus indicating insufficient biokinetic properties of [18F]9 aand [18F]9 cfor D3 receptor imaging in vivo.
A multi‐model approach to intravenous filter optimization
Authors: Vassilevski Y. V. , Simakov S. S. , Kapranov S. A. 
Published: April 2010

AbstractWe present a multi‐model approach to the study of side‐effects of endovascular implants. A 2D model of elastic walls and a local 3D model of blood flow are combined with a 1D network blood circulation model. The three numerical models form an endovascular computational stand. Copyright © 2010 John Wiley & Sons, Ltd.
A scheduling and load balancing scheme for dynamic P2P‐based system
Authors: Zhang Ming , Ajaltouni Elie El , Boukerche Azzedine 
Published: April 2010

AbstractScheduling and load balancing have been one of the key issues in distributed systems due to their significant impact on system performance as well as system resource utilization. With the rapid development of Peer‐to‐Peer (P2P) network technology, traditional scheduling and load balancing techniques are facing new challenges because P2P‐based systems require more dynamic mechanisms for task scheduling and load balancing among heterogeneous network computing nodes. In this paper, we propose a scheme for dynamic scheduling and load balancing in a P2P‐based environment. Our scheme aims at Service‐Oriented P2P‐based distributed systems, however, it can be applied to traditional distributed architecture straightforwardly. Furthermore, we evaluate the performance of our scheme using simulation experiments in a cluster‐based distributed computing environment. Indeed, our results show that our scheme can achieve significant system performance gain compared to commonly used random and round robin scheduling algorithms in P2P‐based systems. Meanwhile, we use a real‐time distributed simulation to evaluate our algorithm, which can provide more trustful results in terms of performance evaluation. Indeed, the ease of using a distributed real‐time simulation, to measure the real‐time performance of the algorithm can promote more flexible and efficient methods for the development of load balancing algorithms. This is especially the case for the hard‐to‐predict P2P‐based distributed systems. Copyright © 2010 John Wiley & Sons, Ltd.
Stochastic bounds for performance evaluation of Web services
Authors: Fourneau Jean‐Michel , Mokdad Lynda , Pekergin Nihal 
Published: April 2010

AbstractWe propose new techniques to simplify the computation of the end‐to‐end delay for an evaluation of a Web services model. The simplification processes are associated with stochastic comparisons of random variables. Thus, the simplified models are stochastic bounds for the original ones. In this study, we consider that the Web service model can be represented by an acyclic directed graph. Thus, we propose upper and lower bounds on the response times by considering in one case special random variables for service times and in the other case we substitute the precedence graph by another one. We prove that the response times computed on the bounding models are really upper and lower bounds on the considered models. We also propose to generalize the model by considering the contention time when several executions of composite Web services are invocated. We propose in this case upper and lower bounds on response times by proposing bounding models. The response times are easier to compute on these new models. We give the corresponding proofs based on stochastic comparisons. We present several numerical results in order to show the accuracy of our bounds. Copyright © 2010 John Wiley & Sons, Ltd.
Performance measurement and analysis tools for extremely scalable systems
Authors: Mohr B. , Wylie B. J. N. , Wolf F. 
Published: April 2010

AbstractHigh‐performance computing systems continue to employ more and more processor cores. Current typical high‐end machines in industry, university, and government research laboratory computing centers feature thousands of computing cores. While these machines promise ever more compute power and memory capacity to tackle today's complex simulation problems, they force application developers to greatly enhance the scalability of their codes to be able to exploit it. To better support them in their porting and tuning process, many parallel‐tools research groups have already started to work on scaling their methods, techniques, and tools to extreme processor counts. In this paper, we survey existing profiling and tracing tools, report on our experience in using them in extreme scaling environments, review working and promising new methods and techniques, and discuss strategies for solving open issues and problems. Copyright © 2010 John Wiley & Sons, Ltd.
Interplay of Magnetic Exchange Interactions and NiSNi Bond Angles in Polynuclear Nickel(II) Complexes
Authors: Krupskaya Yulia , Alfonsov Alexey , Parameswaran Anupama , Kataev Vladislav , Klingeler Rüdiger , Steinfeld Gunther , Beyer Norman , Gressenbuch Mathias , Kersting Berthold , Büchner Bernd 
Published: April 2010

AbstractThe ability of bridging thiophenolate groups (RS−) to transmit magnetic exchange interactions between paramagnetic NiII ions is examined. Specific attention is paid to complexes with large NiSRNi angles. For this purpose, dinuclear [Ni2L1(μ‐OAc)⋅I2][I5] (2) and trinuclear [Ni3L2(OAc)2][BPh4]2 (3), where H2L1 and H2L2 represent 24‐membered macrocyclic amino‐thiophenol ligands, are prepared and fully characterized by IR‐ and UV/Vis spectroscopy, X‐ray crystallography, static magnetization M measurements and high‐field electron spin resonance (HF‐ESR). The dinuclear complex 2 has a central N3Ni2(μ‐S)2(μ‐OAc)Ni2N3 core with a mean NiSNi angle of 92°. The macrocycle L2 supports a trinuclear complex 3, with distorted octahedral N2O2S2 and N2O3S coordination environments for one central and two terminal NiII ions, respectively. The NiSNi angles are at 132.8° and 133.5°. We find that the variation of the bond angles has a very strong impact on the magnetic properties of the Ni complexes. In the case of the Ni2‐complex, temperature T and magnetic field B dependencies of M reveal a ferromagnetic coupling J=−29 cm−1 between two NiII ions (H=JS1S2). HF‐ESR measurements yield a negative axial magnetic anisotropy (D<0) which implies a bistable (easy axis) magnetic ground state. In contrast, for the Ni3‐complex we find an appreciable antiferromagnetic coupling J′=97 cm−1 between the NiII ions and a positive axial magnetic anisotropy (D>0) which implies an easy plane situation.
Photophysics of two Prototypical Molecular‐Wire Building Blocks: Solvent‐Induced Conformational Dynamics?
Authors: Rosspeintner Arnulf , Angulo Gonzalo , Onitsch Christine , Kivala Milan , Diederich François , Grampp Günter , Gescheidt Georg 
Published: April 2010

AbstractThe photophysics of two molecular wire building blocks of different lengths based on p‐phenyleneethylene, namely, 1,4‐bis[p‐(N,N‐dimethylamino)phenyl]‐1,2‐ethyne and 1,4‐bis[p‐(N,N‐dihexylamino)phenylethynyl]benzene, are studied experimentally in a wide range of organic solvents. The band shape and position of the electronic absorption and fluorescence emission of both compounds are discussed in terms of the empirical Catalán linear solvent energy relationship and the analytical solvation model of Liptay. It is found that solute polarizability plays an important part in the description of the pronounced solvatochromism for these highly symmetric molecules. In addition, the dependence of the emission quantum yield and the excited‐state lifetime on the solvent are measured. The experimental findings can only be partially rationalized by the common theoretical models. They indicate that not only torsion about the triple bonds but also solvent–solute reorganization must be taken into account.