bluuebunny/crossref_metadata_2025_split huggingface dataset:
HUBUNGAN MENARKE DINI DENGAN KEJADIAN KARSINOMA MAMMAE DI RS MUHAMMADIYAH PALEMBANG
Authors: Pratiwi Ratih , Alqausar Mohammad Virgo , Tanzila Raden Ayu 
Published: June 2024

Karsinoma mammae (kanker payudara) merupakan karsinoma yang menempati urutan pertama penyebab kematian wanita di Indonesia. Salah satu faktor risiko karsinoma mammae adalah menarke dini. Menarke merupakan suatu peristiwa menstruasi yang terjadi pertama kali dalam periode kehidupan seorang wanita. Menarke menandai matangnya organ reproduksi seorang wanita. Penelitian ini bertujuan untuk mengetahui hubungan antara menarke dini dengan kejadian karsinoma mammae. Penelitian ini menggunakan desain analisis kuantitatif dengan pendekatan cross sectional. Penelitian dilakukan di RS Muhammadiyah Palembang. Sampel yang digunakan dalam penelitian ini adalah sebanyak 100 orang. Pengambilan sampel dilakukan dengan metode Total Sampling. Hasil penelitian menunjukkan prevalensi karsinoma mammae sebanyak 79 orang (79,0%). Proporsi terbesar pada kelompok umur 51- 60 tahun, yaitu sebanyak 44 orang (44,0%). Subjek penelitian yang mengalami menarke dini adalah 73 orang(73,0 %). Ada 45 orang yang memiliki usia melahirkan anak pertama pada usia 21-25 (45,0 %). Terdapat 35 kasus karsinoma mammae dalam keluarga. Ada 70 sampel dengan riwayat keluarga menderita karsinoma (70,0%). Sebanyak 85 orang memiliki siklus menstruasi teratur. Ada 64 orang yang merupakan akseptor keluarga berencana dan 33 diantaranya adalah pengguna kontrasepsi oral kombinasi (51,6%). Sampel yang telah mengalami menopause ada 49 orang (49,0%) dan terbanyak terjadi pada usia 46-50 tahun (61,2%). Terdapat hubungan yang bermakna antara menarke dini dengan kejadian karsinoma mammae (p- value = 0,021). Disimpulkan ada hubungan antara menarke dini dengan kejadian karsinoma mammae pada pasien di RS Muhammadiyah Palembang
KOMPETENSI, MOTIVASI KERJA, DAN KINERJA KARYAWAN PT. BLUE BIRD TBK KOTA BEKASI
Authors: Puspasari Mardiana , Febriani Yunita , Puspa Azahra Yosefanny 
Published: June 2024

Purpose –The aim of the research is to determine the influence of competence and work motivation on the performance of PT employees. Blue Bird Tbk. (Pool Narogong) Bekasi City both simultaneously and partially. Design/methodology –This type of research used is associative research. The sample used in this study was 67 respondents from a total population of 200 permanent employees. The sampling technique used was the Proportionate Stratified Random Sampling technique. The data collection method used is through questionnaires and documentation. Data analysis used in this research is quantitative and qualitative data analysis, using a Likert scale. The data analysis technique used in this study is using multiple linear regression analysis, F test (simultaneous), t test (partial) and the coefficient of determination. Findings - The results of the research based on multiple linear regression show that competence and work motivation have a positive effect on the performance of employees at PT. Blue Bird Tbk. (Pool Narogong) Bekasi City. The results of the F hypothesis test show that there is a significant effect of competence and work motivation on the performance of employees of PT. Blue Bird Tbk. (Pool Narogong) Bekasi City. The results of the t hypothesis test show that there is a partial effect of competence and work motivation on the performance of employees of PT. Blue Bird Tbk. (Pool Narogong) Bekasi City. The results of the coefficient of determination show that the variables of competence and work motivation can contribute to the ups and downs of performance by 69.3%, while the rest are influenced by other variables not included in this study.
Implementation of Text Processing Techniques on Citizen Opinions Regarding Floods in Surabaya
Authors: Kriswibowo Rony , Alia Putri Ariatna , Prayogo Johan Suryo , Febriana Rusina Widha 
Published: June 2024

An analysis of residents opinions on flooding in Surabaya is essential to identify their perceptions and aspirations towards this disaster. This can facilitate the making of appropriate flood mitigation policies. The current problem is that it is difficult to retrieve data from X in the form of both users and tweets automatically. So that in some studies that use tweet data becomes less efficient in the data collection process. This research confirmed the use of messages to determine highly impactful disaster zones and showed how tweets can be used to identify oscillations in disaster intensity over time. The topic of this research is to apply the Data Crawling method to obtain datasets on social media X. Then the next method is text preprocessing using Wordcloud, Matplotlib, (NTLK) Natural Language Toolkit, and Sastrawi libraries. In natural language processing, the data to be extracted includes unstructured or “arbitrary” data. In normal dialect preparing (NLP), the information to be extracted includes unstructured or "self-assertive" information. For future purposes (assumption examination, subject modeling, etc.), such information must be changed over into organized data. The discoveries of the think about can help the organization in comprehending the necessities and inclinations of the people with respect to surges. This article demonstrates how Artificial Intelegence may be applied to text data analysis in order to provide insightful findings. the outcomes of this research can help the government in making more effective policies to overcome flooding in Surabaya
PENGARUH KEPEMILIKAN MANAJERIAL DAN KEBIJAKAN HUTANG TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY (CSR) (Studi Empiris Pada Perusahaan Manufaktur Sektor Konsumsi Sub-Sektor Pengolahan Makanan Yang Terdaftar di Bursa Efek Indonesia Tahun 2017-2021
Authors: Dewi Eka kusuma , Romadhina Anggun Putri 
Published: June 2024

The definition of Corporate Social Responsibility can be seen in Law number 40 of 2007 concerning Limited Liability Companies (UUPT) article 1 paragraph 3 states that social and environmental responsibility is the company's commitment to participate in sustainable economic development in order to improve the quality of life and a beneficial environment, both for the company itself, the local community and society in general. CSR emerged as a result of the modernization of society which already understands that activities carried out by companies can have a negative impact on the environment. Moreover, this is very close to the activities carried out by manufacturing companies because manufacturing companies are the companies that interact the most with the public. Factors that influence CSR disclosure in this research are managerial ownership and debt policy. This type of research uses quantitative research using secondary data in the form of company annual reports taken from the non-cyclical consumer sector, food processing subsector listed on the Indonesia Stock Exchange for the period 2017 to 2021. The sampling method uses purposive sampling. From the research results, it is proven that managerial ownership does not influence CSR disclosure and conversely debt policy influences CSR disclosure. Meanwhile, simultaneously, managerial ownership together with debt policy influence CSR disclosure.
Inhibition mechanism investigation of quercetagetin as a potential tyrosinase inhibitor
Authors: Liang Faliang 
Published: June 2024

Tyrosinase is one important rate limiting enzyme in melanin synthesis, directly affecting the melanin synthesis. Quercetagetin is one active ingredient from marigold. Thence, the inhibition effects of quercetagetin against tyrosinase were investigated. The results showed quercetagetin could inhibit tyrosinase activity with IC50 value of 0.19 ± 0.01 mM and the inhibition type was a reversible mixed-type. Results of fluorescence quenching showed quercetagetin could quench tyrosinase fluorescence in static process. CD and 3D fluorescence results showed the interaction of quercetagetin to tyrosinase could change tyrosinase conformation to inhibit activity. Moreover, docking revealed details of quercetagetin’s interactions with tyrosinase.
Causality of genetically proxied immunophenotypes on cardiovascular diseases: a Mendelian randomization study
Authors: Wang Xuehan , Cheng Huixin , Feng Meng , Jiang Bing , Ren Chunzhen , Chen Qilin , Zhi Xiaodong , Li Yingdong 
Published: June 2024

BackgroundCardiovascular diseases (CVDs) stand as the foremost global cause of mortality, prompting a growing interest in using the potential of immune cells for heart injury treatment. This study aims to assess the causal association between immune cells and CVDs.MethodsA total of 731 immune cells were derived from a previously published genome-wide association study (GWAS), which included approximately 22 million genetic variants among 3,757 individuals of Sardinian ancestry. Genetic associations with atrial fibrillation (AF), heart failure, coronary artery disease, myocardial infarction and stroke were extracted from large-scale GWAS. A two-sample Mendelian randomization (MR) analysis was used to assess the causal association between immune cells and CVDs. Replication MR analysis based on FinnGen dataset and meta-analysis are sequentially conducted to validate causal relationships.ResultsCollectively, genetically predicted 4 immune cell traits were associated with AF and 5 immune cell traits were associated with stroke. Increased levels of IgD- CD38dim absolute count were associated with a higher susceptibility to AF, while increased expression of CD14+ CD16+ monocytes, CD62L on CD62L+ myeloid dendritic cells, and CD16 on CD14- CD16+ monocytes were linked to a decreased susceptibility to AF. Additionally, an elevated susceptibility to stroke was linked to an increase in the percentage of CD39+ resting Tregs and heightened CD27 expression on IgD- CD38+ cells. Conversely, a decreased susceptibility to stroke was associated with increased CD40 expression on monocytes, particularly on CD14+ CD16+ and CD14+ CD16- monocytes, with the latter two showing the most compelling evidence.ConclusionThis study identified several immune cell traits that have a causal relationship with CVDs, thus confirming that immune cells play an important role in the pathogenesis of these diseases.
Allogeneic hematopoietic stem cell transplant for familial hemophagocytic lymphohistiocytosis: a case report and literature review
Authors: Bingjie Liu , Linlin Zhang , Futian Ma , Fan Xuan , Huan Du , Wu Xiaoli , Zhou Lixia , Fuxu Wang , Xuejun Zhang , Ying Wang 
Published: June 2024

ObjectivesThis study aims to discuss the clinical manifestations and treatment of Familial hemophagocytic lymphohistiocytosis (FHL) caused by a mutation in the UNC13D gene.MethodsA 6-year-old female child presented with unexplained febricity, splenomegaly, pancytopenia, hemophagocytic lymphohistiocytosis in bone marrow, decreased NK cell activity, soluble CD25 levels &gt; 44000ng/ml. Genetic sequencing revealed a mutation in the UNC13D gene. Additionally, the patient experienced intermittent fever with seizures characterized by involuntary twitching of the left upper limb. Head magnetic resonance imaging (MRI) showed white matter lesions.ResultsAccording to the HLH-2004 diagnostic criteria revised by the International Society of Histiocytosis the patient was diagnosed with FHL. Despite receiving HLH-2004 treatment, the disease relapsed. However, after a salvage allogeneic Hematopoietic Stem Cell Transplant (HSCT), febricity, abnormal blood cells, and neurological symptoms significantly improved.ConclusionsPrompt performance of allogeneic HSCT is crucial upon diagnosis of FHL, especially when neurological involvement is present.
Analyzing the quality differences between healthy and moldy cigar tobacco leaves during the air-curing process through fungal communities and physicochemical components
Authors: Fu Kejian , Song Xueru , Cui Yonghe , Zhou Qi , Yin Yuming , Zhang Jilai , Zhou Hongyin , Su Youbo 
Published: June 2024

IntroductionThe air-curing process of cigar tobacco, as a key step in enhancing the quality of cigars, is often susceptible to contamination by mold spores, which severely constrains the quality of cigar tobacco.MethodsThis study employed high-throughput Illumina sequencing technology and a continuous flow analysis system to analyze the differences between the microbial communities and physicochemical components of moldy and healthy cigar tobacco leaves. Furthermore, correlation analysis was performed to reveal the impact of mold on the quality of cigar tobacco.ResultsThe differences between the microbial flora and physicochemical compositions of moldy (MC) and healthy (HC) tobacco leaves were analyzed, revealing significant disparities between the two groups. Aspergillus spp. represented the dominant mold in MC, with nine out of twelve isolated molds showing higher quantities on MC than on HC. Mold contamination notably decreased the total nitrogen (TN), total phosphorus (TP), total alkaloids (TA), starch, protein, and flavor constituents while increasing the total fatty acid esters (TFAA), which was accompanied by a shift towards weakly acidic pH in the leaves. Fungal community analysis indicated a significant reduction in the fungal operational taxonomic unit (OUT) numbers and diversity indices in MC, contrasting with the bacterial trends. Aspergillus exhibited significantly higher relative abundance in MC, with LEfSe analysis pinpointing it as the primary driver of differentiation. Furthermore, significant negative correlations were observed between Aspergillus and TP, starch, TA, and protein, while a significant positive association was evident with TFAA. Network analysis underscored the pivotal role of Aspergillus as the species influencing disparities between HC and MC, with its abundance serving as a critical determinant during the air-curing process.DiscussionThis study elucidated substantial quality distinctions between MC and HC during air-curing, with Aspergillus emerging as the key species contributing to leaf mold.
Effectiveness of galcanezumab on sleep quality, migraine outcome, and multidimensional patient-reported outcome measures: a real-world experience in Turkish patients with episodic and chronic migraine
Authors: Ilgaz Aydinlar Elif , Erdogan Soyukibar Tuba , Yalinay Dikmen Pinar 
Published: June 2024

IntroductionThis real-world study aimed to investigate the impact of galcanezumab on sleep quality, migraine outcome and multidimensional patient-reported outcomes measures (PROMs) in patients with episodic migraine (EM) and chronic migraine (CM).MethodsFifty-four patients with episodic migraine (n = 24) or chronic migraine (n = 30) received a 3-month series of galcanezumab injections and were evaluated for sleep quality, measured using the Pittsburgh Sleep Quality Index (PSQI), as well as migraine outcomes such as monthly headache days (MHDs), monthly migraine days (MMDs), and headache severity. Patient-reported outcome measures (PROMs) such as the Migraine Disability Assessment Scale (MIDAS), Headache Impact Test-6 (HIT-6), SF-36 Health-related Quality of Life (HRQoL), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI) were additionally included in the assessment.ResultsThe percentage of patients with poor sleep quality (total PSQI scores ≥ 5) was 72.7% at baseline, decreasing to 57.5% and 56.2% at the 1st and 2nd months, respectively. By the 3rd month of galcanezumab injections, significant improvement was observed in the sleep disturbances domain in the overall study population (p = 0.016), and in subgroups of patients with low anxiety levels (p = 0.016) and none/minimal depression (p = 0.035) at baseline. Patients with sleep disorder at baseline exhibited marked improvements in total PSQI scores (p = 0.027) and in the subjective sleep quality (p = 0.034) and daytime dysfunction (p = 0.013) domains, by the 3rd month. Over the 1st, 2nd, and 3rd months, there were significant improvements in MHDs (p &lt; 0.001), MMDs (p &lt; 0.001), HIT-6 scores (p &lt; 0.001 for each), BAI scores (p &lt; 0.001 for each), BDI scores (p ranged from 0.048 to &lt;0.001), and HRQoL scores (p ranged from 0.012 to &lt;0.001).ConclusionGalcanezumab demonstrates notable benefits in improving sleep quality, along with a comorbidity-based and domain-specific effect on sleep parameters, which involved sleep disturbances domain in patients without depression or anxiety at baseline but the total PSQI scores, subjective sleep quality and daytime dysfunction in those with sleep disorder at baseline. The treatment also facilitates rapid-onset enhancements in migraine outcomes as well as various PROMs.
Orthorectic behavior among students and motivation for physical activity, dietary habits, and restrictive eating
Authors: Rozmiarek Mateusz , Grajek Mateusz , Krupa-Kotara Karolina , Malchrowicz-Mośko Ewa 
Published: June 2024

IntroductionOrthorexia lacks official recognition as an eating disorder; however, orthorexic behaviors, associated with a stringent selection of food, may serve as a predisposing factor to the development of eating disorders. It is characterized by an obsessive preoccupation with healthy eating and strict dietary standards, often prevalent in high-risk groups such as athletes and individuals concerned with their physical appearance. The objective of this study was to evaluate the incidence of orthorexia among students exhibiting varying lifestyles (including dietary habits and levels of physical activity, along with their respective motivational factors). The research involved 600 participants equally distributed between health-related (HRF) and non-health-related (NRF) academic categories, with the majority of participants in the HRF category being women.MethodsAssessments included BMI calculations, dietary evaluation based on Polish standards, categorization of physical activity levels, the EMI-2 questionnaire on motivation to exercise, the DOS test for orthorexia propensity, and the TFEQ-13 questionnaire for eating behavior.Results and discussionResults showed that primary motivators for physical activity included disease prevention, health maintenance, strength/endurance, and physical appearance. Orthorexia tendencies were prevalent, particularly in the HRF group, linked to lower BMI, better diet quality, higher physical activity levels, and a higher prevalence of restrictive eating. In conclusion, students in health-related fields, driven by a strong health consciousness, are at risk of orthorexia. This emphasizes the need for balanced health education and support.ConclusionOrthorexic tendencies are associated with distorted perceptions of food portions and calories, underscoring the importance of awareness and intervention.
Kratom safety and toxicology in the public health context: research needs to better inform regulation
Authors: Henningfield Jack E. , Grundmann Oliver , Huestis Marilyn A. , Smith Kirsten E. 
Published: June 2024

Although kratom use has been part of life for centuries in Southeast Asia, the availability and use of kratom in the United States (US) increased substantially since the early 2000s when there was little information on kratom pharmacology, use patterns, and effects, all critical to guiding regulation and policy. Here we provide a synthesis of research with several hundred English-language papers published in the past 5 years drawing from basic research, epidemiological and surveillance data, and recent clinical research. This review of available literature aims to provide an integrated update regarding our current understanding of kratom’s benefits, risks, pharmacology, and epidemiology, which may inform United States-based kratom regulation. Recent surveillance indicates there are likely several million past-year kratom consumers, though estimates vary widely. Even without precise prevalence data, kratom use is no longer a niche, with millions of United States adults using it for myriad reasons. Despite its botanical origins in the coffee tree family and its polypharmacy, kratom is popularly characterized as an opioid with presumed opioid-system-based risks for addiction or overdose. Neuropharmacology, toxicology, and epidemiology studies show that kratom is more accurately characterized as a substance with diverse and complex pharmacology. Taken together the work reviewed here provides a foundation for future scientific studies, as well as a guide for ongoing efforts to regulate kratom. This work also informs much-needed federal oversight, including by the United States Food and Drug Administration. We conclude with recommendations for kratom regulation and research priorities needed to address current policy and knowledge gaps around this increasingly used botanical product.
Effectiveness of acupuncture combined with auricular acupressure in the treatment of postoperative ileus: a study protocol for a randomized controlled trial
Authors: Lyu Ruoyun , Wen Zonglin , Huang Rong , Yang Zhiling , Chen Yingqun 
Published: June 2024

BackgroundAbout one-third of patients experience postoperative ileus (POI) after abdominal surgery, which can cause various complications and has not been treated well in clinical practice. The comprehensive treatment offered by traditional Chinese medicine may be a good choice for promoting intestinal mobility. Therefore, the aim of this study protocol is to observe the effectiveness of acupuncture combined with auricular acupressure in decreasing the incidence and related symptoms of POI.MethodsThis is a single-center, assessor-blinded, randomized controlled trial. A total of 160 participants are supposed to recruit at Shanghai Tenth People's Hospital and randomly divided into two parallel groups in a 1:1 ratio. The intervention group are planned to receive manual acupuncture combined with auricular acupressure, while the control group are planned to receive regular enhanced recovery after surgery treatment. The primary outcome is the time to first defecation and first flatus after surgery. The secondary outcomes include the length of postoperative hospital stay, intensity of postoperative abdominal pain and distension, severity of postoperative nausea and vomiting, time to tolerate diet, inflammatory index, and incidence of prolonged postoperative ileus.DiscussionThe results of this research will provide substantial evidence regarding the efficacy of comprehensive traditional Chinese treatment, specifically auricular acupressure and manual acupuncture, in treating and preventing POI.
Trial registrationClinicalTrials.gov, Identifier: ChiCTR2300075983, registered on September 21, 2023.