bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and Anticancer Activity of Novel Betulinic acid and Betulin Derivatives
Authors: Kommera Harish , Kaluđerović Goran N. , Kalbitz Jutta , Paschke Reinhard 
Published: August 2010

AbstractA series of novel betulinic acid derivatives 3–11 and betulin derivatives 12–17 were synthesized. The compounds were characterized by the means of 1H‐ and 13C‐NMR spectroscopy as well as mass spectrometry. The compounds have been tested on ten tumor cell lines of different histogenic origin. The most active derivatives, containing a chloroacetyl group on C‐3 in betulinic acid 9 and C‐28 in betulin 15, were up to ten times more cytotoxic and many fold more selective towards tumor cells in comparison to normal cells (fibroblasts) than betulinic acid. Furthermore, compound 15 was found to possess cell growth inhibition even when treated for a short time on anaplastic thyroid cancer cells (SW1736).
Efficacy, safety, and effects on blood pressure of naproxcinod 750 mg twice daily compared with placebo and naproxen 500 mg twice daily in patients with osteoarthritis of the hip: A randomized, double‐blind, parallel‐group, multicenter study
Authors: Baerwald Christoph , Verdecchia Paolo , Duquesroix Brigitte , Frayssinet Hayet , Ferreira Thierry 
Published: August 2010

AbstractObjectiveTo test the superiority of naproxcinod compared with placebo in relieving the signs and symptoms of hip osteoarthritis and to assess the safety of naproxcinod and its effects on blood pressure.MethodsIn a 13‐week, randomized, double‐blind, parallel‐group, multicenter study, 810 patients were randomized to receive either naproxcinod 750 mg twice daily, placebo, or naproxen 500 mg twice daily (2:2:1). Primary efficacy analyses compared naproxcinod and placebo using an analysis of covariance for 3 co‐primary end points (the Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC] pain and function subscales and patient's overall rating of disease status). Safety assessments included adverse events and in‐office blood pressure measurements.ResultsThe least squares mean changes from baseline were significantly greater with naproxcinod than with placebo (P < 0.0001) and were similar to those with naproxen at week 13 for the WOMAC pain score (−25.81, −17.97, and −24.31 mm, respectively), the WOMAC function score (−22.24, −13.45, and −21.67 mm, respectively), and patient's rating of disease status (0.86, 0.51, and 0.82, respectively). Changes from baseline in systolic blood pressure were similar in the naproxcinod and placebo groups at weeks 2, 6, and 13 (differences between groups of 0.25, −0.45, and −0.11 mm Hg, respectively). Changes in the naproxen group were greater than those in the placebo group (differences of 3.11, 3.03, and 2.00 mm Hg, respectively). Systolic blood pressure increases ≥10 mm Hg from baseline to week 13 occurred in 13.3%, 15.0%, and 20.3% of patients receiving naproxcinod, placebo, and naproxen, respectively. Naproxcinod and naproxen had similar adverse event and general safety profiles.ConclusionThe efficacy of naproxcinod for treating the signs and symptoms of hip osteoarthritis was statistically superior to that of placebo and similar to that of naproxen. Naproxcinod was well tolerated, with effects on systolic blood pressure similar to those of placebo.
Musculoskeletal disease burden of hereditary hemochromatosis
Authors: Sahinbegovic Enijad , Dallos Tomáš , Aigner Elmar , Axmann Roland , Manger Bernhard , Englbrecht Matthias , Schöniger‐Hekele Maximilian , Karonitsch Thomas , Stamm Tanja , Farkas Martin , Karger Thomas , Stölzel Ulrich , Keysser Gernot , Datz Christian , Schett Georg , Zwerina Jochen 
Published: August 2010

AbstractObjectiveTo determine the prevalence, clinical picture, and disease burden of arthritis in patients with hereditary hemochromatosis.MethodsIn this cross‐sectional observational study of 199 patients with hemochromatosis and iron overload, demographic and disease‐specific variables, genotype, and organ involvement were recorded. The prevalence, intensity, and localization of joint pain were assessed, and a complete rheumatologic investigation was performed. Radiographs of the hands, knees, and ankles were scored for joint space narrowing, erosions, osteophytes, and chondrocalcinosis. In addition, the number and type of joint replacement surgeries were recorded.ResultsJoint pain was reported by 72.4% of the patients. Their mean ± SD age at the time of the initial joint symptoms was 45.8 ± 13.2 years. If joint pain was present, it preceded the diagnosis of hemochromatosis by a mean ± SD of 9.0 ± 10.7 years. Bony enlargement was observed in 65.8% of the patients, whereas synovitis was less common (13.6%). Joint space narrowing and osteophytes as well as chondrocalcinosis of the wrist and knee joints were frequent radiographic features of hemochromatosis. Joint replacement surgery was common, with 32 patients (16.1%) undergoing total joint replacement surgery due to severe OA. The mean ± SD age of these patients was 58.3 ± 10.4 years at time of joint replacement surgery. Female sex, metacarpophalangeal joint involvement, and the presence of chondrocalcinosis were associated with a higher risk of early joint failure (i.e., the need for joint replacement surgery).ConclusionArthritis is a frequent, early, and severe symptom of hemochromatosis. Disease is not confined to involvement of the metacarpophalangeal joints and often leads to severe damage requiring the replacement of joints.
Replication stress, a source of epigenetic aberrations in cancer?
Authors: Jasencakova Zuzana , Groth Anja 
Published: August 2010

AbstractCancer cells accumulate widespread local and global chromatin changes and the source of this instability remains a key question. Here we hypothesize that chromatin alterations including unscheduled silencing can arise as a consequence of perturbed histone dynamics in response to replication stress. Chromatin organization is transiently disrupted during DNA replication and maintenance of epigenetic information thus relies on faithful restoration of chromatin on the new daughter strands. Acute replication stress challenges proper chromatin restoration by deregulating histone H3 lysine 9 mono‐methylation on new histones and impairing parental histone recycling. This could facilitate stochastic epigenetic silencing by laying down repressive histone marks at sites of fork stalling. Deregulation of replication in response to oncogenes and other tumor‐promoting insults is recognized as a significant source of genome instability in cancer. We propose that replication stress not only presents a threat to genome stability, but also jeopardizes chromatin integrity and increases epigenetic plasticity during tumorigenesis.
Biosynthesis, metabolism, molecular engineering, and biological functions of stilbene phytoalexins in plants
Authors: Jeandet Philippe , Delaunois Bertrand , Conreux Alexandra , Donnez David , Nuzzo Vitale , Cordelier Sylvain , Clément Christophe , Courot Eric 
Published: August 2010

AbstractStilbenic compounds recently have become the focus of a number of studies in medicine and plant physiology as well as have emerged as promising molecules that potentially affect human health. Stilbenes are relatively simple compounds synthesized by plants and deriving from the phenyalanine/polymalonate route, the last and key enzyme of this pathway being stilbene synthase. Here, we review the biological significance of stilbenes in plants together with their biosynthesis pathway and their metabolism both by fungi andin planta. Special attention will be paid to the role of stilbenic molecules as phytoalexins.
Interruption of a 310‐helix by a single Gly residue in a poly‐Aib motif: A crystallographic study
Authors: Solà Jordi , Helliwell Madeleine , Clayden Jonathan 
Published: August 2010

AbstractThe structural influence of a single Gly residue inserted into an Aib16 homooligomer was studied in the solid state by X‐ray crystallography. The peptides N3Aib8GlyAib8PheNH2 (1) and CbzPheAib8GlyAib8 (2) were found to adopt well‐defined helical structures, which are broadly 310 helical. Indeed, 2 is the longest crystallographic 310 helix thus far reported. However, in the region of the central Gly residue, a loosening of the 310 structure is observed in both peptides, with 1 clearly showing local adoption of an α‐helical structure in the region of residues 7–9. © 2010 Wiley Periodicals, Inc. Biopolymers 95: 62–69, 2011.
Ionic Mixed Interactions in Macromolecules
Authors: Ciferri Alberto 
Published: August 2010

AbstractPurely ionic interactions in natural and synthetic macromolecules involve the mutual interaction of fixed charges and their interaction with mobile ions. Such charge‐dependent interactions lead to well‐documented effects, including chain expansion of polyelectrolytes, globularization of polyampholytes, distributions of mobile ions according to charge screening, or ion condensation models. A variety of structural features, functions, and applications of these systems is amplified by the superimposition of charge‐independent effects associated with the occurrence of less polar or hydrophobic groups, special salts, surfactants, or complementary protein assemblies. For instance, ionic and hydrophobic attractive interactions stabilize pearls (or rings)‐on‐a‐string conformations, possibly a model for the formation of the chromatin assembly. The attractive interactions due to hydrophobic fatty acid groups attached to polysaccharides promote the formation of vesicles that entrap and slowly release water‐soluble drugs. Intra‐ and intermolecular associations based on ion‐pairing mixed interactions also control the formation of host–guest compounds, protein conformation, and the assembly of layered polyelectrolytes. Metallo‐supramolecular polymers and networks are formed due to the coordination of multivalent cations with bi‐ and trifunctional organic ligands. The association of lithium salts to polymers in the absence of water allows the formation of highly efficient energy sources. It also allows the identification of the ionic species that control charge‐independent contributions to Hofmeister effects. This critical review presents a synthetic classification of systems displaying ionic mixed interactions, and a discussion of underlying molecular mechanisms.
ChemInform Abstract: Synthesis and Properties of the Sodium Lithium Silicate Silinaite.
Authors: BENEKE K. , THIESEN P. , LAGALY G. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Pressure Synthesis and Structure of the New Spinel‐Related Series LnCu2O4 (Ln: Nd, Gd, Er, Lu, Y).
Authors: CHEN B.‐H. , WALKER D. , SUARD E. Y. , SCOTT B. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Solvent Effects on the Solvolysis of p‐Nitrobenzyl and 3,5‐Bis( trifluoromethyl)benzyl p‐Toluenesulfonates.
Authors: FUJIO M. , SUSUKI T. , GOTO M. , TSUJI Y. , YATSUGI K. , KIM S. H. , AHMED G. A.‐W. , TSUNO Y. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Partially and Perfluorinated Thioketones and Thioaldehydes: Chemical Storage, in situ Generation and Surprising Reactivity Towards Bis( trimethylstannyl)‐diazomethane (BTSD) and C,N‐Bis(triisopropylsilyl) nitrilimine (NI).
Authors: HASSERODT J. , PRITZKOW H. , SUNDERMEYER W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient and General Synthesis of Alkanediyl Diphenols.
Authors: GRUETTNER C. , BOEHMER V. , ASSMUS R. , SCHERF S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Functionalized Pyridines and Thiophenes by Michael Addition of Some β‐Keto Carbothioic Acid Anilides to Electrophilic Olefins.
Authors: BOGDANOWICZ‐SZWED K. , NOWAK I. , TYRKA M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nickel‐Mediated Flash Isomerization: A New Approach to 1,4‐But‐1‐ene Diol Derivatives.
Authors: MALANGA C. , URSO A. , LARDICCI L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Sodium Chlorite ‐ Yet Another Oxidant for Thiols to Disulfides.
Authors: RAMADAS K. , SRINIVASAN N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Hydrogenation of Carboxylic Acids Using Bimetallic Catalysts Consisting of Group 8 to 10, and Group 6 or 7 Metals.
Authors: HE D.‐H. , WAKASA N. , FUCHIKAMI T. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive Homo‐Coupling of Methyl 2‐Br‐2‐Cl‐Carboxylates Promoted by CuBr‐Fe0.
Authors: BENINCASA M. , FORTI L. , GHELFI F. , PAGNONI U. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Selective 1,4‐Reduction of Conjugated Aldehydes and Ketones in the Presence of Unconjugated Aldehydes and Ketones with Sodium Dithionite.
Authors: DHILLON R. S. , SINGH R. P. , KAUR D. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple One‐Pot Synthesis of Functionalized Ketimines from Ketones and Amine Hydrochloride Salts.
Authors: SELVA M. , TUNDO P. , MARQUES C. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Acyl(phenylselanyl)methylidene(triphenyl)‐λ5‐ arsanes and Their Wittig‐Type Reactions.
Authors: HUANG Z.‐Z. , HUANG X. , HUANG Y.‐Z. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Acyloin Condensation of 1,2‐Diacyloxyethanes: Directed Synthesis of Unsymmetrically Substituted 1,2‐Bis‐(trimethylsiloxy)ethenes.
Authors: FRIEDRICH K. , HAESLER J. , PULST S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile Tandem Michael Addition‐Retro Dieckmann Reaction of Cyclic . beta.‐Ketoesters: One‐Pot Preparation of Polyfunctionalized Acyclic Derivatives.
Authors: FILIPPINI M.‐H. , RODRIGUEZ J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Organometallic Route to 2′‐Hydroxy‐6′‐methoxy‐acetophenone.
Authors: MINCHEVA Z. , VELKOV J. , BOIREAU G. , BARRY J. , FUGIER C. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Six‐Membered Ring Opening of Isopropylidene Malonate Derivatives: Synthesis of α,β‐Unsaturated Thio‐ and Selenoaryl Carboxylic Esters.
Authors: BAO W. , ZHANG Y. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Regioselectivities in the Catalyzed Conjugate Addition of Organoaluminum and Organotitanium Reagents to Sterically Hindered Enones: Investigation of the Methylation of 10β‐Methyl‐δ1,9‐ 2‐octalones.
Authors: KABBARA J. , FLEMMING S. , NICKISCH K. , NEH H. , WESTERMANN J. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Photoinduced Molecular Transformations. Part 152. Ring Expansion Based on a Sensitized (2 + 2) Photoaddition of Enol Ethers of Cyclic Ketones with Olefins, Followed by a β‐Scission of Alkoxyl Radicals Generated from the Resulting Cyclobutanols. Two‐Carbon Ring Expansion of β‐Indanone, β‐Tetralone and β‐Suberone.
Authors: SUGINOME H. , TAKEDA T. , ITOH M. , NAKAYAMA Y. , KOBAYASHI K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Pyrazole Amino Acids
Authors: EL MAHDI O. , LAVERGNE J.‐P. , VIALLEFONT PH. , AKSSIRA M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of 3‐Methyl‐1‐phenyl‐2‐pyrazoline‐4,5‐dione with Amines.
Authors: METWALLY S. A. M. , ATTA F. M. , ABD EL‐MONEM M. E. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Analgesic Activity of 2‐Amino‐5‐tert‐butyl‐2‐oxazoline.
Authors: SERRANO M. I. , SERRANO J. S. , FERNANDEZ A. , SANCHEZ‐CARRASCO J. M. , FUENTES J. , PRADERA M. A. , ORTIZ M. C. , GARCIA FERNANDEZ J. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of 5‐Oxodihydroisoxazoles. Part 12. Trapping of Derived Ketenimines with Lithium Amides and Alkyllithiums.
Authors: ANG K. H. , PRAGER R. H. , WILLIAMS C. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 2‐Benzopyrylium Salts. Part 45. Interaction of 2‐Benzopyrylium Salts and Their Monocyclic Analogues with Ketone Imines.
Authors: TOSUNYAN D. E. , VERIN S. V. , KUZNETSOV E. V. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Asymmetric Synthesis of Benzo(c)pyrans Related to the Aphid Pigments.
Authors: GILES R. G. F. , JOLL C. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.