bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of the Modified Caregiver Strain Index in a Sample of Black and White Persons Living With Dementia and Their Caregivers
Authors: Pereira-Osorio Carolina , Brickell Emily , Lee Bern , Arredondo Beth , Sawyer Robert John 
Published: May 2024

Abstract

Background and Objectives
This study examined the performance of the Modified Caregiver Strain Index (MCSI) in a sample of Black and White caregivers of persons living with dementia.

Research Design and Methods
Data on 153 dyads enrolled in the Care Ecosystem dementia care management program were analyzed, including sociodemographic variables, dementia severity, and caregiver burden and wellbeing. Factor structure, item-response patterns, and concurrent validity were assessed across racial groups.

Results
Differences between Black and White caregivers included gender, dyad relation, and socioeconomic disadvantage. Factor structure and item loadings varied by racial cohort, with parameters supporting a 3-factor model. For Black caregivers, finances and work, emotional and physical strain, and family and personal adjustment items loaded together on individual factors. For White caregivers physical and emotional strain items loaded on separate factors, although personal and family adjustment items loaded with work and financial strain items. Item-level analysis revealed differences between groups, with Black caregivers endorsing physical strain to a greater degree (p = .003). Total MCSI scores were positively correlated with concurrent measures like the PHQ-9 (White: r = 0.67, Black: r = 0.54) and the GAD-2 (White: r = 0.47, Black: r = 0.4), and negatively correlated with self-efficacy ratings (White: r = −0.54, Black: r = −0.55), with a p &lt; .001 for all validity analysis.

Discussion and Implications
The MCSI displayed acceptable statistical performance for Black and White caregivers of persons living with dementia and displayed a factor structure sensitive to cultural variations of the construct. Researchers results highlight the inherent complexity and the relevance of selecting inclusive measures to appropriately serve diverse populations.
Multivariate processing of airborne natural source electromagnetic data—application to field data from Gobabis (Namibia)
Authors: Thiede A , Schiffler M , Junge A , Becken M 
Published: May 2024

SUMMARY
As deep-seated ore deposits become increasingly relevant for mineral exploration, the demand for time-efficient and powerful deep-sounding exploration methods rises. A suitable method for efficiently sensing ores at great depth is airborne electromagnetics (EM) using natural signal of atmospheric origin. The method relates airborne magnetic field recordings in the audio-frequency range to reference magnetic field recordings measured at a ground-based site and can achieve greater penetration depths when compared to controlled source airborne EM techniques. However, airborne natural source EM data are prone to noise caused by platform vibrations especially deteriorating data quality at low frequencies and thus narrowing the depth of investigation. Motional noise manifests as coherent noise on all airborne magnetic field components demanding for a powerful processing tool to remove such kind of noise. Unlike the bivariate approach, which is widely used in natural source EM, the multivariate approach is capable of detecting and reducing the effect of coherent noise. We introduce a robust multivariate processing for airborne natural source EM data and present the code implementation. The code was applied to a large-scale data set from the Kalahari–Copper–Belt in Namibia covering over 1000 km2. We obtained spatially consistent and smooth sounding curves in a frequency range of 10 to 1000 Hz including frequencies with prominent motional noise. Transfer functions are in good agreement with other geophysical and geological information.
An integrated method for gravity gradient inversion and gravity gradient depth imaging
Authors: Tian Yu , Liu Jinzhao , Ye Qing , Shi Lei , Wang Yong , Ebbing Jörg 
Published: May 2024

SUMMARY
Gravity gradient data can show the structural features of geological bodies in the shallow lithosphere with higher sensitivity and resolution than conventional gravity data. Gravity gradient inversion can be applied to obtain the lithospheric density structures of geological bodies. However, as with gravity data, gravity gradient data have no inherent depth resolution. The methods of gravity gradient depth imaging and gravity gradient inversion are integrated in this study. The depth imaging method is effective for calculations without prior information and iterative computations. As the parameters in the depth weighting function should be chosen from a set of values used in inversion tests of synthetic data, which brings some uncertainties, the depth imaging results of gravity gradient are introduced into the depth weighting function. Several synthetic models are tested to demonstrate the advantages and features of the effective integrated method. Finally, the integrated method is applied to the interpretation of the GOCE satellite gravity gradient tensors over the northeastern margin of the Qinghai–Tibet Plateau. The results reveal that in the crust of the study area, the distribution of density anomalies is more in line with the mechanism of the crustal flow model, in the upper mantle of the study area, the density anomalies are mainly influenced by the high heat flow environment.
Into the red: an M-band study of the chemistry and rotation of β Pictoris b at high spectral resolution
Authors: Parker Luke T , Birkby Jayne L , Landman Rico , Wardenier Joost P , Young Mitchell E , Vaughan Sophia R , van Sluijs Lennart , Brogi Matteo , Parmentier Vivien , Line Michael R 
Published: May 2024

ABSTRACT
High-resolution cross-correlation spectroscopy (HRCCS) combined with adaptive optics has been enormously successful in advancing our knowledge of exoplanet atmospheres, from chemistry to rotation and atmospheric dynamics. This powerful technique now drives major science cases for ELT instrumentation including METIS/ELT, GMTNIRS/GMT, and MICHI/TMT, targeting biosignatures on rocky planets at 3–5 μm, but remains untested beyond 3.5 μm where the sky thermal background begins to provide the dominant contribution to the noise. We present 3.51–5.21 μm M-band CRIRES+/VLT observations of the archetypal young directly imaged gas giant β Pictoris b, detecting CO absorption at S/N = 6.6 at 4.73 μm and H2O at S/N = 5.7, and thus extending the use of HRCCS into the thermal background noise dominated infrared. Using this novel spectral range to search for more diverse chemistry, we report marginal evidence of SiO at S/N = 4.3, potentially indicative that previously proposed magnesium–silicate clouds in the atmosphere are either patchy, transparent at M-band wavelengths, or possibly absent on the planetary hemisphere observed. The molecular detections are rotationally broadened by the spin of β Pic b, and we infer a planetary rotation velocity of vsin(i) = 22 ± 2 km s−1 from the cross-correlation with the H2O model template, consistent with previous K-band studies. We discuss the observational challenges posed by the thermal background and telluric contamination in the M-band, the custom analysis procedures required to mitigate these issues, and the opportunities to exploit this new infrared window for HRCCS using existing and next-generation instrumentation.
A general method to reconstruct strong gravitational lenses based on the singular perturbative approach
Authors: Alard C 
Published: May 2024

ABSTRACT
The number of gravitational arcs systems detected is increasing quickly and should even increase at a faster rate in the near future. This wealth of new gravitational arcs requires the development of a purely automated method to reconstruct the lens and source. A general reconstruction method based on the singular perturbative approach is proposed in this paper. This method generates a lens and source reconstruction directly from the gravitational arc image. The method is fully automated and works in two steps. The first step is to generate a guess solution based on the circular solution in the singular perturbative approach. The second step is to break the sign degeneracy and to refine the solution by using a general source model. The refinement of the solution is conducted step-by-step to avoid the source-lens degeneracy issue. One important asset of this automated method is that the lens solution is written in universal terms which allows the computation of statistics. Considering the large number of lenses which should be available in the near future this ability to compute unbiased statistics is an important asset.
A Catalogue and analysis of ultra-diffuse galaxy spectroscopic properties
Authors: Gannon Jonah S , Ferré-Mateu Anna , Forbes Duncan A , Brodie Jean P , Buzzo Maria Luisa , Romanowsky Aaron J 
Published: May 2024

ABSTRACT
In order to facilitate the future study of ultra-diffuse galaxies (UDGs), we compile a catalogue of their spectroscopic properties. Using it, we investigate some of the biases inherent in the current UDG sample that have been targeted for spectroscopy. In comparison to a larger sample of UDGs studied via their spectral energy distributions (SED), current spectroscopic targets are intrinsically brighter, have higher stellar mass, are larger, more globular cluster-rich, older, and have a wider spread in their metallicities. In particular, many spectroscopically studied UDGs have a significant fraction of their stellar mass contained within their globular cluster (GC) system. We also search for correlations between parameters in the catalogue. Of note is a correlation between alpha element abundance and metallicity, as may be expected for a ‘failed galaxy’ scenario. However, the expected correlations of metallicity with age are not found, and it is unclear if this is evidence against a ‘failed galaxy’ scenario or simply due to the low number of statistics and the presence of outliers. Finally, we attempt to segment our catalogue into different classes using a machine learning K-means method. We find that the clustering is very weak and that it is currently not warranted to split the catalogue into multiple, distinct subpopulations. Our catalogue is available online, and we aim to maintain it beyond the publication of this work.
Strategies for biofilm optimization of plastic-degrading microorganisms and isolating biofilm formers from plastic-contaminated environments
Authors: McFall Adam , Coughlin Scott A , Hardiman Gary , Megaw Julianne 
Published: May 2024

Abstract
The perpetual disposal of plastic waste, combined with ineffective waste management strategies, has resulted in widespread environmental plastic pollution. Microbial plastic biodegradation represents an emerging solution to this problem. However, biodegradation studies tend to overlook the fundamental prerequisite of initial surface colonization via biofilm formation. This study had two independent but connected aims relating to plastic surface colonization by microorganisms: to enhance biofilm formation by known plastic degraders, with translational potential for improved plastic degradation, and to isolate microorganisms from microplastic contaminated environments with the ability to colonize plastic surfaces. Planktonic and biofilm responses to diverse carbon and energy sources were investigated over 7 days, using Bacillus subtilis 168, Fusarium solani (Martius) Saccardo, Ideonella sakaiensis 201-F6, Pseudomonas putida KT2440, and Rhodococcus ruber C208. This enabled optimal conditions for biofilm formation by each strain to be determined. In parallel, environmental samples containing synthetic or natural polymeric substances (anaerobic digestate, landfill leachate, and microplastic contaminated compost) were incubated with polyethylene and polyethylene terephthalate films, to isolate microorganisms capable of colonizing their surfaces. This yielded eight bacterial isolates from three genera: Bacillus, Lysinibacillus, and Proteus. These genera contain species that have been shown to degrade plastics and other recalcitrant synthetic polymers, demonstrating the success of our approach. This study also suggests that discrete plastic types may create different ecological niches which can be exploited by unique bacterial colonizers. Our findings underscore the importance of considering plastic colonization by microbial biofilms in the context of their biodegradation.
Merging Photorefractive Keratectomy and Collagen Crosslinking: An Analysis of Literature and a Guide to Prevalent Protocols
Authors: Moshirfar Majid , Rognon Gregory T. , Olson Nate , Kay Walker , Sperry R. Alek , Ha Seungyeon , Hoopes Phillip C. 
Published: May 2024

Purpose:
The purpose of this review was to summarize the different surgical approaches combining photorefractive keratectomy (PRK) and corneal crosslinking (CXL), present each protocol template in a simple format, and provide an overview of the primary outcomes and adverse events.

Methods:
A literature review was conducted as outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Eight different databases were searched. Papers were included if PRK was immediately followed by CXL.

Results:
Thirty-seven papers met the inclusion criteria of a total yield of 823. The latest research into simultaneous PRK and CXL has been shown to not only stabilize the cornea and prevent keratoconus progression but also improve the visual acuity of the patient. Improvements in uncorrected distance visual acuity and (spectacle) corrected distance visual acuity were found to be significant when considering all protocols. There were also significant reductions in K1, K2, mean K, Kmax, sphere, cylinder, and spherical equivalent. Random-effects analysis confirmed these trends. Corrected distance visual acuity was found to improve by an average of 0.18 ± 1.49 logMAR (Cohen's D [CD] 0.12; P <0.02). There was also a significant reduction of 2.57 ± 0.45 D (CD 5.74; P <0.001) in Kmax. Cylinder and spherical equivalent were also reduced by 1.36 ± 0.26 D (CD 5.25; P <0.001) and 2.61 ± 0.38 D (CD 6.73; P <0.001), respectively.

Conclusions:
Combining the 2 procedures appears to be of net benefit, showing stabilization and improvement of ectatic disease, while also providing modest gains in visual acuity. Since customized PRK and CXL approaches appear superior, a combination of these would likely be best for patients.
Prophylactic Therapy for Long-Term Ocular Discomfort After Cataract Surgery
Authors: Di Zazzo Antonio , Spelta Sara , Micera Alessandra , De Gregorio Chiara , Affatato Marzia , Esposito Graziana , Balzamino Bijorn Omar , Sgrulletta Roberto , Coassin Marco , Bonini Stefano 
Published: May 2024

Purpose:
The cataract surgery dissatisfaction rate is 20% to 35% due to ocular surface discomfort. We investigate the ocular surface discomfort after surgical failure as a consequence of age-related parainflammation. We also aim to prevent it by immune-modulating prophylactic management.

Methods:
Monocentric clinical trial realized in a teaching hospital. Prospective, randomized, open-label, unmasked clinical trial. One hundred patients diagnosed with cataracts underwent phacoemulsification surgery. Groups A (<65 years; n = 25) and B (>75 years; n = 25) received surgery only. Groups C and D (both >75 years and both n = 25) used cyclosporine A 0.1% cationic emulsion (CE) eye drops or CE lubricating eye drops (both twice daily), respectively, for 30 days before surgery. Patients were followed up 90 days after surgery. The primary outcome was postoperative ocular surface failure; secondary outcomes examined the influence of prophylactic cyclosporine A 0.1% CE therapy on ocular surface outcomes.

Results:
Group B demonstrated greater severity regarding ocular surface signs and symptoms throughout the study period, versus all other groups. Signs/symptoms were typically lower in Group A. Group C achieved significant reductions in conjunctival Symptom Assessment in Dry Eye values (P < 0.05), conjunctival hyperemia severity (P < 0.01), and meibomian gland dysfunction (P < 0.001) at Day 45, versus Group B, and tear break-up time was increased (P < 0.001). Ocular surface inflammatory marker transcription (HLADR, intercellular adhesion molecule 1 [ICAM-1], and interleukin 6 [IL-6]) was significantly downregulated in Group C, versus Group B, at 90 days (P < 0.05).

Conclusions:
Cataract surgery induced ocular surface system failure with a clinically significant persistent inflammatory status (InflammAging) in patients older than 75 years. Prophylactic cyclosporine A 0.1% CE eye drops were associated with improved ocular surface homeostasis and reductions in inflammatory markers.
Multimodal Quality Initiatives in Sepsis Care: Assessing Impact on Core Measures and Outcomes
Authors: Garcia Marcos , Al-Jaghbeer Mohammed , Morrison James , Boustany Antoine , Ghimire Bindesh , Tapryal Neel , Mushtaq Komal , Orlosky Kelly , Flowers-Surovi Amy , Murphy Christopher , Rath Palak , Rahman Muhaimen , Kickel Corrine , Lee Yu-Che , Chang Ko-Yun , Abi Fadel Francois 
Published: May 2024

ABSTRACT
Providing timely and effective care for patients with sepsis is challenging due to delays in recognition and intervention. The Surviving Sepsis Campaign has developed bundles that have been shown to reduce sepsis mortality. However, hospitals have not consistently adhered to these bundles, resulting in suboptimal outcomes. To address this, a multimodal quality improvement sepsis program was implemented from 2017 to 2022 in a large urban tertiary hospital. The aim of this program was to enhance the Severe Sepsis and Septic Shock Management Bundle compliance and reduce sepsis mortality. At baseline, the Severe Sepsis and Septic Shock Management Bundle compliance rates were low, at 25%, with a sepsis observed/expected mortality ratio of 1.14. Our interventions included the formation of a multidisciplinary committee, the appointment of sepsis champions, the implementation of sepsis alerts and order sets, the formation of a Code Sepsis team, real-time audits, and peer-to-peer education. By 2022, compliance rose to 62%, and the observed/expected mortality ratio decreased to 0.73. Our approach led to improved outcomes and hospital rankings. These findings underscore the efficacy of a comprehensive sepsis care initiative, emphasizing the importance of interdisciplinary collaboration. A multimodal hospital-wide sepsis performance program is feasible and can contribute to improved outcomes. However, further research is necessary to determine the specific impact of individual strategies on sepsis outcomes.
Prognostic stratification of patients with pT4bN0M0 colorectal cancer following multivisceral resection: a multi-institutional case series analysis
Authors: Quan Jichuan , Zuo Kai , Li Guoli , Liu Junguang , Mei Shiwen , Hu Gang , Qiu Wenlong , Zhuang Meng , Meng Ling , Wang Xishan , Chang Hu , Tang Jianqiang 
Published: May 2024

Background:
Colorectal cancer (CRC) patients with stage pT4b are a complex group as they show differences in tumor-infiltrated organs. Patients with the same stage often exhibit differences in prognosis after multivisceral resection (MVR). Thus far, some important prognostic factors have not been thoroughly investigated. Here, we identified the prognostic factors influencing CRC patients at the pT4bN0M0 stage to stratify the prognostic differences among patients.

Materials and methods:
A retrospective analysis was conducted on patients diagnosed with locally advanced CRC and who underwent MVR at three medical institutions from January 2010 to December 2021. The prognostic factors affecting the survival of CRC patients at pT4bN0M0 stage were identified by multivariate Cox proportional hazard models. We then classified the prognosis into different grades on the basis of these independent prognostic factors.

Results:
We enrolled 690 patients with locally advanced CRC who underwent MVR; of these, 172 patients with pT4bN0M0 were finally included. Patients with digestive system [overall survival (OS): hazard ratio (HR)=0.441; 95% confidence interval (CI)=0.217–0.900; P=0.024; disease-free survival (DFS): HR=0.416; 95% CI=0.218–0.796; P=0.008) or genitourinary system invasion (OS: HR=0.405; 95% CI=0.193–0.851; P=0.017; DFS: HR=0.505; 95% CI=0.267–0.954; P=0.035) exhibited significantly better OS and DFS as compared to those with gynecological system invasion, while the OS and DFS were similar between the digestive system and genitourinary system invasion groups (OS: HR=0.941; 95% CI=0.434–2.042; P=0.878; DFS: HR=1.211; 95% CI=0.611–2.403; P=0.583). Multivariate analysis showed that age (OS: HR=2.121; 95% CI=1.157–3.886; P=0.015; DFS: HR=1.869; 95% CI=1.116–3.131; P=0.017) and type of organs invaded by CRC (OS: HR=3.107; 95% CI=1.121–8.609; P=0.029; DFS: HR=2.827; 95% CI=1.142–6.997; P=0.025) were the independent prognostic factors that influenced the OS and DFS of CRC patients with pT4bN0M0 disease. The OS and DFS of patients showing invasion of the gynecological system group were significantly worse (P=0.004 and P=0.003, respectively) than those of patients with invasion of the nongynecological system group. On the basis of the above-mentioned two independent prognostic factors, patients were assigned to high-risk, medium-risk, and low-risk groups. Subgroup analysis showed that the OS and DFS of the medium-risk and high-risk groups were significantly worse (P=0.001 and P=0.001, respectively) than those of the low-risk group.

Conclusion:
Patients with pT4bN0M0 CRC show significant differences in their prognosis. The type of organs invaded by CRC is a valuable indicator for prognostic stratification of CRC patients with pT4bN0M0.
Efficacy of different strategies for reducing labor pain: A Bayesian analysis
Authors: Feng Yuanyan , Zhu Fengjuan , Zhang Junfeng , Zeng Zishan , Li Qiumei 
Published: May 2024

Background:The effectiveness of different medical interventions in managing labor pain has yielded mixed results. Therefore, this systematic review and network meta-analysis aimed to provide a comprehensive summary of the available evidence on the impact of different strategies for reducing labor pain.Methods:We systematically searched 3 English databases (Pubmed, Embase and the Cochrane Library) from inception to January 2023. Randomized controlled trials (RCTs) or controlled clinical trials that investigating the effects of different strategies for reducing labor pain were included in this network meta-analysis. Risk of bias (ROB) was assessed using the Cochrane ROB tools. Network meta-analysis was performed using the R software (version 4.2.1) with gemtc package.Results:A total of 9 studies involving 823 patients, including 9 treatments (acupressure, birth ball exercise, Bonapace method, distraction techniques, ice pressure, LI4 acupressure, lidocaine spray, smartphone-based music intervention and placebo). The surface under the cumulative ranking (SUCRA) shows that Bonapace method ranked first (SUCRA, 79.5%), LI4 acupressure ranked second (SUCRA, 65.6%), distraction technique ranked third (SUCRA, 57.6%), birth ball exercise ranked fourth (SUCRA, 51.8%).Conclusions:According to the results of the network meta-analysis, among the different strategies examined, the Bonapace Method stands out as the most effective nonpharmacological intervention for reducing labor pain. The results of this meta-analysis can aid both patients and healthcare professionals in choosing the most effective techniques to reduce labor pain.