bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deleterious effects of a combination therapy using fluoroquinolones and tetracyclines for the treatment of Japanese spotted fever: a retrospective cohort study based on a Japanese hospital database
Authors: Yasuda Ikkoh , Toizumi Michiko , Sando Eiichiro 
Published: June 2024

Abstract

Objectives
Tetracyclines are the standard treatment for rickettsiosis, including Japanese spotted fever (JSF), a tick-borne rickettsiosis caused by Rickettsia japonica. While some specialists in Japan advocate combining fluoroquinolones with tetracyclines for treating JSF, the negative aspects of combination therapy have not been thoroughly evaluated. Whether fluoroquinolones should be combined with tetracyclines for JSF treatment is controversial. The study aimed to evaluate the disadvantages of fluoroquinolones combined with tetracyclines for JSF treatment.

Methods
This retrospective cohort study was conducted using a Japanese database comprising claims data from April 2008 to December 2020. The combination therapy group (tetracyclines and fluoroquinolones) was compared with the monotherapy group (tetracycline only) regarding mortality and the incidence of complications.

Results
A total of 797 patients were enrolled: 525 received combination therapy, and 272 received monotherapy. The adjusted odds ratio (OR) for mortality was 2.30 [95% confidence interval (CI): 0.28–18.77] in the combination therapy group with respect to the monotherapy group. According to the subgroup analysis, patients undergoing combination therapy with ciprofloxacin experienced higher mortality rates compared with those receiving monotherapy (adjusted OR = 25.98, 95% CI = 1.71–393.75). Additionally, 27.7% of the combination therapy group received NSAIDs concurrently with fluoroquinolones. The combination therapy with NSAIDs group was significantly more likely to experience convulsions than the monotherapy without NSAIDs group (adjusted OR: 5.44, 95% CI: 1.13–26.30).

Conclusions
This study found no evidence that combination therapy improves mortality outcomes and instead uncovered its deleterious effects. These findings facilitate a fair assessment of combination therapy that includes consideration of its disadvantages.
Using Cultural Repertoires during Unsettled Times
Authors: Yang Ye (Nicole) , Ozanne Julie L , Phipps Marcus 
Published: June 2024

Abstract
This research draws on the theory of culture in action, which explains how consumers selectively mobilize their cultural repertoires to understand and solve daily problems. Contemporary life, however, is increasingly unsettled, challenging the adequacy of consumers’ repertoires and how they use existing institutional cultural resources. This qualitative study identifies four ways in which consumers use their cultural repertoires and institutional resources during unsettled times. Formulaic uses are when consumers mobilize familiar cultural tools and existing resources to resettle. Versatile uses are when consumers develop new cultural tools to transform while working within demanding institutional resources. Freewheeling uses are when consumers mobilize familiar cultural tools for play but rework institutional resources to be less demanding. Finally, troubleshooting uses are when consumers extend their existing cultural tools to suffice but reject institutional resources. These varied uses of culture capture how consumers either mobilize or develop their cultural repertoires and institutional resources to serve different ends. This study provides a more dynamic, pragmatic, and nuanced explanation of how consumers summon culture to solve problems during unsettled times. A conceptual model explains this process, and the discussion highlights the theoretical contributions.
Re-thinking the sustainability of sovereign debt
Authors: Bradlow Daniel D , Lastra Rosa M , Park Stephen Kim 
Published: June 2024

Abstract
This article explores the contributions that law can make to the development of a holistic approach to sovereign debt sustainability. We focus on debt sustainability assessments (DSAs) conducted by the International Monetary Fund (IMF), which are linked to the IMF’s surveillance and lending functions, and determine whether it is necessary to restructure the debt of a country in debt distress and the timing, process, and terms of such a debt restructuring. While the precise causes of each country’s debt situation are unique, all countries are grappling with the rising costs and growing risks posed by climate change and other environmental and social factors. We suggest that the IMF’s current treatment of these environmental and social factors is opaque, unpredictable, and hard for the citizens of affected countries and other outsiders to understand. It also obscures the true burden that debt obligations impose on a sovereign and the country’s residents, and, thus, the amount of debt relief that it may need in order to achieve a sustainable debt position. To address these shortcomings, we identify financial, economic, environmental, and social (FEES) factors that we contend should be incorporated in the design of the frameworks governing DSAs and the operating principles and practices of the IMF through which DSAs are conducted. We argue that the IMF should draw on various hard and soft sources of international and transnational law to develop a FEES-based approach to sovereign debt sustainability that is more consistent, predictable, and legitimate than the current approach.
Grief and loss in Shiʿi thought: Zayn al-Dīn al-ʿĀmilī’s (d. 965/1558) Musakkin al-fuʾād
Authors: Izzo Gianni 
Published: June 2024

ABSTRACT
Within scholarship on Islamic ethics, writings on consolation (taʿāzī) are a largely neglected genre. This article is a start on making good this scarcity in the secondary literature. It studies Zayn al-Dīn al-ʿĀmilī’s (d. 965/1558) Musakkin al-fuʾād, a treatise on the grief over the loss of a child and consolations for it. Al-ʿĀmilī’s contribution to the genre presents a Shiʿi view, inflected by a Muʿtazilī understanding of divine justice and theodicy. According to this view, divine recompense (ʿiwaḍ) is offered to the bereaved on the condition of patient resignation with appreciation of the loss in relation to the ordeal and death suffered by the fourteen ‘Infallibles’ (al-maʿṣūmīn). Al-ʿĀmilī’s disparaging outlook on the world (al-dunyā) encourages abandonment of its material attachments through ideal modes of patience (al-ṣabr) and contentment (al-riḍāʾ). Musakkin al-fuʾād imagines a system of reward and loss, calibrated to the lessons of sacred texts. I examine al-ʿĀmilī’s use of these sources, including prophetic narratives, parables, and traditions (aḥādīth), to explore their implications for an idealized expression of Muslim mourning. From these examples, the personal becomes universal, generating moral criteria for an attitude to life, and necessitating appropriately modified responses to death.
Gas assisted binary black hole formation in AGN discs
Authors: Whitehead Henry , Rowan Connar , Boekholt Tjarda , Kocsis Bence 
Published: June 2024

ABSTRACT
We investigate close encounters by stellar mass black holes (BHs) in the gaseous discs of active galactic nuclei (AGNs) as a potential formation channel of binary black holes (BBHs). We perform a series of 2D isothermal viscous hydrodynamical simulations within a shearing box prescription using the Eulerian grid code Athena++. We co-evolve the embedded BHs with the gas keeping track of the energetic dissipation and torquing of the BBH by gas gravitation and inertial forces. To probe the dependence of capture on the initial conditions, we discuss a suite of 345 simulations spanning BBH impact parameter (b) and local AGN disc density (ρ0). We identify a clear region in b − ρ0 space where gas assisted BBH capture is efficient. We find that the presence of gas leads to strong energetic dissipation during close encounters between unbound BHs, forming stably bound eccentric BBHs. We find that the gas dissipation during close encounters increases for systems with increased disc density and deeper periapsis passages rp, fitting a power law such that $\Delta E \propto \rho _0^{\alpha }r_{\mathrm{p}}^{\beta }$, where {α, β} = {1.01 ± 0.04, −0.43 ± 0.03}. Alternatively, the gas dissipation is approximately ΔE = 4.3MdvHvp, where Md is the mass of a single BH minidisc just prior to the encounter when the binary separation is 2rH (two binary Hill radii), vH and vp are the relative BH velocities at 2rH and at the first closest approach, respectively. We derive a prescription for capture which can be used in semi-analytical models of AGN. We do not find the dissipative dynamics observed in these systems to be in agreement with the simple gas dynamical friction models often used in the literature.
NEATH − III. A molecular line survey of a simulated star-forming cloud
Authors: Priestley F D , Clark P C , Glover S C O , Ragan S E , Fehér O , Prole L R , Klessen R S 
Published: June 2024

ABSTRACT
We present synthetic line observations of a simulated molecular cloud, utilizing a self-consistent treatment of the dynamics and time-dependent chemical evolution. We investigate line emission from the three most common CO isotopologues (12CO, 13CO, C18O) and six supposed tracers of dense gas (NH3, HCN, N2H+, HCO+, CS, HNC). Our simulation produces a range of line intensities consistent with that observed in real molecular clouds. The HCN-to-CO intensity ratio is relatively invariant with column density, making HCN (and chemically similar species such as CS) a poor tracer of high-density material in the cloud. The ratio of N2H+ to HCN or CO, on the other hand, is highly selective of regions with densities above $10^{22} \, {\rm cm}^{-2}$, and the N2H+ line is a very good tracer of the dynamics of high volume density ($\gt 10^4 \, {\rm cm}^{-3}$) material. Focusing on cores formed within the simulated cloud, we find good agreement with the line intensities of an observational sample of prestellar cores, including reproducing observed CS line intensities with an undepleted elemental abundance of sulphur. However, agreement between cores formed in the simulation, and models of isolated cores which have otherwise-comparable properties, is poor. The formation from and interaction with the large-scale environment has a significant impact on the line emission properties of the cores, making isolated models unsuitable for interpreting observational data.
Joint inference of multiplicative and additive systematics in galaxy density fluctuations and clustering measurements
Authors: Berlfein Federico , Mandelbaum Rachel , Dodelson Scott , Schafer Chad 
Published: June 2024

ABSTRACT
Galaxy clustering measurements are a key probe of the matter density field in the Universe. With the era of precision cosmology upon us, surveys rely on precise measurements of the clustering signal for meaningful cosmological analysis. However, the presence of systematic contaminants can bias the observed galaxy number density, and thereby bias the galaxy two-point statistics. As the statistical uncertainties get smaller, correcting for these systematic contaminants becomes increasingly important for unbiased cosmological analysis. We present and validate a new method for understanding and mitigating both additive and multiplicative systematics in galaxy clustering measurements (two-point function) by joint inference of contaminants in the galaxy overdensity field (one-point function) using a maximum-likelihood estimator (MLE). We test this methodology with Kilo-Degree Survey-like mock galaxy catalogues and synthetic systematic template maps. We estimate the cosmological impact of such mitigation by quantifying uncertainties and possible biases in the inferred relationship between the observed and the true galaxy clustering signal. Our method robustly corrects the clustering signal to the sub-per cent level and reduces numerous additive and multiplicative systematics from $1.5 \sigma$ to less than $0.1\sigma$ for the scenarios we tested. In addition, we provide an empirical approach to identifying the functional form (additive, multiplicative, or other) by which specific systematics contaminate the galaxy number density. Even though this approach is tested and geared towards systematics contaminating the galaxy number density, the methods can be extended to systematics mitigation for other two-point correlation measurements.
Partial tidal disruption events: the elixir of life
Authors: Sharma Megha , Price Daniel J , Heger Alexander 
Published: June 2024

ABSTRACT
In our Galactic Centre, about $10\,000$ to $100\,000$ stars are estimated to have survived tidal disruption events, resulting in partially disrupted remnants. These events occur when a supermassive black hole (SMBH) tidally interacts with a star, but not enough to completely disrupt the star. We use the 1D stellar evolution code Kepler and the 3D smoothed particle hydrodynamics code Phantom to model the tidal disruption of 1, 3, and $10\, \mathrm{M}_\odot$ stars at zero-age main sequence (ZAMS), middle-age main sequence (MAMS), and terminal-age main sequence (TAMS). We map the disruption remnants into Kepler in order to understand their post-distribution evolution. We find distinct characteristics in the remnants, including increased radius, rapid core rotation, and differential rotation in the envelope. The remnants undergo composition mixing that affects their stellar evolution. Although the remnants formed by disruption of ZAMS models evolve similarly to unperturbed models of the same mass, for MAMS and TAMS stars, the remnants have higher luminosity and effective temperature. Potential observational signatures include peculiarities in nitrogen and carbon abundances, higher luminosity, rapid rotation, faster evolution, and unique tracks in the Hertzsprung–Russell diagram.
Maf1 phosphorylation is regulated through the action of prefoldin-like Bud27 on PP4 phosphatase in Saccharomyces cerevisiae
Authors: Gutiérrez-Santiago Francisco , Martínez-Fernández Verónica , Garrido-Godino Ana Isabel , Colino-Palomino Cristina , Clemente-Blanco Andrés , Conesa Christine , Acker Joël , Navarro Francisco 
Published: June 2024

Abstract
Bud27 is a prefoldin-like protein that participates in transcriptional regulation mediated by the three RNA polymerases in Saccharomyces cerevisiae. Lack of Bud27 significantly affects RNA pol III transcription, although the involved mechanisms have not been characterized. Here, we show that Bud27 regulates the phosphorylation state of the RNA pol III transcriptional repressor, Maf1, influences its nuclear localization, and likely its activity. We demonstrate that Bud27 is associated with the Maf1 main phosphatase PP4 in vivo, and that this interaction is required for proper Maf1 dephosphorylation. Lack of Bud27 decreases the interaction among PP4 and Maf1, Maf1 dephosphorylation, and its nuclear entry. Our data uncover a new nuclear function of Bud27, identify PP4 as a novel Bud27 interactor and demonstrate the effect of this prefoldin-like protein on the posttranslational regulation of Maf1. Finally, our data reveal a broader effect of Bud27 on PP4 activity by influencing, at least, the phosphorylation of Rad53.
The Fate of The Broken Tether
Authors: Tetreault Tyler A. , Phan Tiffany N. , Wren Tishya A.L. , Heffernan Michael J. , Welborn Michelle C. , Smith John T. , El-Hawary Ron , Cheung Kenneth , Illingworth Kenneth D. , Skaggs David L. ,   Pediatric Spine Study Group, Andras Lindsay M. 
Published: June 2024

Study Design.
Retrospective, multicenter.

Objective.
The aim of this study was to assess curve progression and occurrence of revision surgery following tether breakage after vertebral body tethering (VBT).

Summary of Background Data.
Tether breakage after VBT is common with rates up to 50% reported. In these cases, it remains unknown whether the curve will progress or remain stable.

Materials and Methods.
Adolescent and juvenile idiopathic scoliosis patients in a multicenter registry with ≥2-year-follow-up after VBT were reviewed. Broken tethers were listed as postoperative complications and identified by increased screw divergence of >5 degrees on serial radiographs. Revision procedures and curve magnitude at subsequent visits were recorded.

Results.
Of 186 patients who qualified for inclusion, 84 (45.2%) patients with tether breakage were identified with a mean age at VBT of 12.4±1.4 years and mean curve magnitude at index procedure of 51.8±8.1 degrees. Tether breakage occurred at a mean of 30.3±11.8 months and mean curve of 33.9±13.2 degrees. Twelve patients (12/84, 14.5%) underwent 13 revision procedures after tether breakage, including six tether revisions and seven conversions to fusion. All tether revisions occurred within 5 months of breakage identification. No patients with curves <35 degrees after breakage underwent revision. Revision rate was greatest in skeletally immature (Risser 0–3) patients with curves ≥35 degrees at time of breakage (Risser 0–3: 9/17, 53% vs. Risser 4–5: 3/23, 13%, P=0.01). Curves increased by 3.1 and 3.7 degrees in the first and second year, respectively. By 2 years, 15/30 (50%) progressed >5 degrees and 8/30 (26.7%) progressed >10 degrees. Overall, 66.7% (40/60) reached a curve magnitude >35 degrees at their latest follow-up, and 14/60 (23.3%) reached a curve magnitude >45 degrees. Skeletal maturity did not affect curve progression after tether breakage (P>0.26), but time to rupture did (P=0.048).

Conclusions.
While skeletal immaturity and curve magnitude were not independently associated with curve progression, skeletally immature patients with curves ≥35 degrees at time of rupture are most likely to undergo additional surgery. Most patients can expect progression at least 5 degrees in the first 2 years after tether breakage, though longer term behavior remains unknown.

Level of Evidence.
Level III.
Impact of Topical 0.05% Cyclosporine A Eye Drops on Post–Femtosecond-Assisted Laser In Situ Keratomileusis Ocular Surface Recovery: A Randomized Clinical Trial
Authors: Zhao Lu , Duan Hongyu , Ma Baikai , Yang Tingting , Zhou Yifan , Liu Yilin , Chen Jiawei , Chen Yueguo , Qi Hong 
Published: June 2024

Objectives:
To investigate the effect of topical 0.05% cyclosporine A (CsA) eye drops as an adjunct to conventional therapy in maintaining post–femtosecond-assisted laser in situ keratomileusis (FS-LASIK) ocular surface stability.

Methods:
Sixty-six patients (eyes) undergoing FS-LASIK were randomized into 2 groups: 33 patients (eyes) in group I (conventional treatment group) and 33 patients (eyes) in group II (CsA group). Conventional treatments include topical levofloxacin, fluorometholone, and artificial tears. Group II received topical 0.05% CsA eye drops twice daily for three months in addition to conventional treatment. Ocular Surface Disease Index (OSDI), numerical rating scale (NRS), tear break-up time (TBUT), Schirmer I test (SIt), corneal fluorescein staining (CFS), conjunctival lissamine green (LG) staining, corneal sensitivity, and corneal nerve morphology were measured. In addition, tear inflammatory cytokine levels were measured using the Luminex assay. Follow-up was performed preoperatively and 1 and 3 months postoperatively.

Results:
In the CsA group, OSDI, TBUT, LG, corneal sensitivity, and corneal nerve fiber total branch density recovered better than in the conventional treatment group. As for tear inflammatory cytokines, interferon (INF) -γ, interleukin (IL)-10, and IL-6 levels were significantly higher in the conventional treatment group as compared with the CsA group. In addition, no significant differences in NRS, SIt, and CFS scores were observed between the two groups.

Conclusion:
In conclusion, 0.05% CsA eye drops is a useful adjunct to conventional treatment for restoring the ocular surface stability after corneal refractive surgery and is more potent in sustaining anti-inflammatory effects.
Losartan May Not Prevent Vestibular Schwannoma Growth or Related Hearing Loss During Observation
Authors: Lovin Benjamin D. , Nader Marc-Elie , Qing Yun , Hernandez Mike , Raza Shaan , DeMonte Franco , Gidley Paul W. 
Published: June 2024

Objective
To evaluate the impact of losartan on vestibular schwannoma (VS) growth and related hearing loss during observation.

Study design
Retrospective cohort study

Setting
Tertiary referral center

Patients
Sporadic VS patients undergoing initial observation with at least two magnetic resonance imaging and audiologic examinations.

Intervention
Losartan

Main Outcome Measures
Endpoints included VS growth, quantitative audiologic changes, survival free of tumor growth, and survival free of nonserviceable hearing. Patient characteristics and endpoints were compared by losartan use.

Results
Seventy-nine patients were included, of which 33% were taking losartan. Tumor growth was observed in 50% of patients in the losartan group and 36% in the non-losartan group (p = 0.329). Survival analysis failed to show a significant difference in the hazard rate of VS growth between groups (hazard ratio, 1.38; 95% confidence interval, 0.70–2.70; p = 0.346). Throughout observation, mean decreases in normalized pure-tone average were 5.5 and 9.3 dB in the losartan and non-losartan groups, respectively (p = 0.908). Mean decreases in normalized word recognition score were 11.0 and 16.6% in the losartan and non-losartan groups, respectively (p = 0.757). Nonserviceable hearing developed in 19% of patients in the losartan group and 28% in the non-losartan group (p = 0.734). Survival analysis did not demonstrate a significant difference in the hazard rate of developing nonserviceable hearing between groups (hazard ratio, 1.71; 95% confidence interval, 0.56–5.21; p = 0.337).

Conclusions
Losartan use may not reduce the risk of VS growth or hearing loss during observation. A randomized trial would be ideal to further identify the true effect on growth and hearing.
Clinical efficacy of TEVAR utilizing fenestrated stent-grafts for zone 0 in an elderly frail patient with giant aortic arch aneurysm
Authors: Kurobe Hirotsugu , Hori Takaki , Fujita Hiroshi , Higaki Tomohide , Fukunishi Takuma , Sogabe Hitoshi , Izutani Hironori 
Published: June 2024

Introduction and importance:
Elderly and frail patients with thoracic aortic aneurysms (TAAs) near to origins of cervical arteries present facing challenges with aortic arch replacement with cardiopulmonary bypass, and traditional tube-type stent-grafts are also inadequate for transcatheter endovascular aortic repair (TEVAR). Thus, necessitating precise treatment with fenestrated stent-grafts from zone 0. This approach is crucial for achieving favorable postoperative outcomes without compromising activities of daily living (ADL).

Case presentations:
An 85-year-old-man admitted to the hospital for treatment of a large TAA. While arch replacement is a definitive procedure, it is highly invasive, and the postoperative ADL are expected to be significantly lower than preoperative levels. Therefore, we performed a debranching TEVAR from Zone 0 with fenestrated stent-graft. The patient was discharged from the hospital on the 11th postoperative day.

Clinical discussion:
In frail and elderly patients for whom conventional surgery may not be viable, TEVAR emerges as a preferred alternative. However, TEVAR of TAA proximal to the aortic arch continues to pose challenges, necessitating meticulous attention to the cervical branches in the intervention strategy. While surgical intervention in these patients necessitates careful consideration of its suitability, including the potential for postoperative enhancement in ADL, the use of fenestrated stent-grafts from Zone 0 emerges as one of the treatment modalities.

Conclusion:
The authors present a very elderly case in which fenestrated stent-grafts were used to avoid aortic arch replacement for a large aortic arch aneurysm, resulting in a good postoperative course with no decline in ADL.