bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychopharmacotherapy factor in the variants of COVID-19 course in psychiatric inpatients
Authors: Neznanov N. G. , Limankin O. V. , Shabelnik A. V. , Azarova L. A. , Lutova N. B. , Bocharova M. O. , Sorokin M. Yu. 
Published: April 2024

The aim of this study is to examine the relationship between the severity and duration criteria of COVID-19 and the psychopharmacotherapy administered to patients in within a psychiatric hospital.Materials and Methods. We analyzed 169 case histories involving completed clinical cases of COVID-19 treatment in a specialized infectious psychiatric department in St. Petersburg, covering the period from May 2020 to January 2021. Correlation, dispersion, and regression analyses were employed to evaluate severe and mild COVID-19 progression indicators, as well as the duration of persistent SARS-CoV-2 viral shedding. We assessed the clinical and laboratory parameters in patients, along with the psychopharmacotherapy administered, including antidepressants, antipsychotics, and acid sphingomyelinase inhibitors (FIASMA-active drugs).Results. Cardiovascular diseases emerged as a predictor of severe COVID-19 when combined with an increasing platelet-to-lymphocyte ratio (PLR), increasing the risk of severe course by over two-fold. The use of any psychotropic agents was associated with a 0.9% increase in the risk of severe course of COVID-19 for each unit increase in the systemic inflammation index PLR, specifically in patients with intellectual disability (ICD-10 codes F70-79), when compared to patients with schizophrenia (ICD-10 codes F20-29). High PLR values and the use of FIASMA-active drugs were associated with prolonged COVID-19 duration, while antidepressant therapy and elevated C-reactive protein levels were associated with a reduced predicted duration of viral shedding in 13.8% of variance. Additional consideration of the nosology of psychiatric disorders in the regression model increased the proportion of explained variance to 22.8%.Conclusion. Consideration should be given to thymoanaleptic therapy for individuals with psychiatric disorders during periods of increased disease incidence leading up to potential SARS-CoV-2 infection, as it may serve as a protective factor against COVID-19. Furthermore, there is no evidence to suggest adverse effects of antipsychotics on the severity and duration of COVID-19. Further research is required to investigate the effects of FIASMA-active psychopharmacological agents within nosologically homogeneous groups.
Performance of cognitive tasks and functional brain activity in anxiety disorders
Authors: Kirenskaya A. V. , Fedorova E. V. , Telesheva K. Yu. , Gonopolsky A. M. , Chernorizov A. M. 
Published: April 2024

Objective. To improve understanding of psychophysiological underpinnings of anxiety disorders a comprehensive study, that included the analysis of cognitive tasks performance, event-related potentials and psychometric scales, has been conducted.Materials and Methods. Participants were patients with generalized anxiety disorder (GAD group — 12 s.), mixed anxiety and depressive disorder (ADD group — 16 s.) and healthy volunteers (control group — 16 s.). The psychometric techniques included the questionnaires of Spielberger, HADS (Hospital Anxiety and Depression Scale) and Carver-White (BIS/BAS Scale). Psychophysiological methods included antisaccade task (AS) and event-related evoked potentials P300 that were recorded during auditory oddball task.Results. The significantly increased anxiety and depression scales, as well as the decreased BAS Reward Responsiveness scale, was found in patients of both clinical groups compared to control one; the increased BIS scale was revealed only in ADD group. In GAD and ADD groups AS performance was worse in response to stimuli in left hemi-field that are initially processed in right hemisphere; on the contrary, decreased number of target stimuli omissions was found in oddball task in clinical groups. P300 amplitude was larger, and P300 latency was shorter for patients with ADD compared to controls. Analysis of asymmetry demonstrated that P300 amplitudes were greater over the frontal-central right than over the left hemisphere in ADD group.Conclusion. The study demonstrated that anxiety disorders are accompanied by reallocation of attentional resources and changes in functional organization of brain networks involved in attention and executive functions. With the same direction, the shifts were greater in ADD group.
Screening for anxiety and depression in the general population: Adaptation of the Patient Health Questionnaire-4 in Russia
Authors: Zolotareva A. A. , Kostenko V. Yu. , Lebedeva A. A. , Chumakova M. A. 
Published: April 2024

The Patient Health Questionnaire-4 (PHQ-4) is one of the most well-known and widely used instruments for assessing anxiety and depressive symptoms.Objective. The aim of this study was to adapt the Russian-language version of the PHQ-4 in the general population.Material and Methods. Data collection was carried out with the help of the service «Anketolog». The participants were 2,000 Russians (1,000 men and 1,000 women) aged 18 to 60 years (M = 38.78; SD = 9.25).Results. The psychometric analysis confirmed the internal reliability and discriminative validity of the adapted questionnaire. The proof of the factor validity of the Russian version of the PHQ-4 was the identification of a two-factor structure describing the symptoms of anxiety and depression, and factor invariance by age, level of education, marital status, parental status, financial status and place of residence. Among the Russians, 44.9% had clinically significant anxiety symptoms and 42.9% had clinically significant depressive symptoms. Russians with anxiety and depressive symptoms more often sought counseling from a psychologist, coach, psychiatrist and neurologist, underwent psychopharmacological treatment in connection with psychological requests, contacted support groups and a psychological help hotline, used online products of automated or semi-automated psychological support, read psychological literature and used psychoactive substances.Conclusion. The psychometric properties of the Russian-language version of the PHQ-4 turned out to be similar to the psychometric characteristics of the original version of the questionnaire, and therefore the adapted questionnaire can be recommended for screening anxiety and depression in the general Russianspeaking population.
TEACHER- STUDENTS EDUCATIONAL COMMUNICATION: A DESCRIPTIVE STUDY IN MIN 2 BANJAR
Authors: Ayuni Risa Dwi , Afifah Noor , Junaidy Junaidy , Apriliyanti Rizki 
Published: April 2024

Communication is an important aspect that involves interaction between teachers and students in the hope that the message will be well received and have an impact on understanding and changes in behavior. This research aims to analyze teacher-student communication in the educational process at MIN 2 Banjar. The method used is descriptive qualitative with interviews, observation and documentation. The result shows that communication in teaching and learning activities at MIN 2 Banjar very effective with approach of epistemological, axiological, and ontologically. The second, the Laswell Model is widely used in communication process that which can flexibly change from group communication to interpersonal communication; The third, educational communication is also effective because of the teacher play varied roles like speaker, moderator, mentor, and manager.
The influence of goods’ quality on their price indices
Authors: Зямалов В.Е. , Турунцева М.Ю. 
Published: April 2024

В работе приводится пример применения гедонического метода корректировки индексов цен, учитывающий влияние изменений качества товаров на их потребительскую стоимость. Метод, первые попытки применения которого относятся к началу ХХ в. и который был окончательно оформлен Грилихесом в 1961 г., позволяет разделить наблюдаемое изменение цены на часть, определяемую инфляционными процессами, и на часть, связанную с изменениями в потребительских качествах товаров. В зарубежной литературе метод получил широкое освещение, он был применен к ценам различных товаров: от потребительской электроники до стоимости билетов на авиарейсы. В настоящее время метод часто применяется для изучения рынка недвижимости. В то же время в отечественной литературе сравнительно мало работ по данной теме. В настоящей работе авторы сделали попытку применить гедонический метод к ценам на потребительскую электронику (портативные персональные компьютеры, ноутбуки) и подержанные автомобили. Также авторами представлены обновленные результаты из опубликованных ранее работ, касающиеся мобильных телефонов и телевизоров. Применение метода показало, что полученные с его помощью индексы цен, учитывающие изменения качества, статистически значимо отличаются от индекса средних наблюдаемых цен.
This paper provides an example of applying the hedonic method of adjusting price indices that takes into account the impact of changes in the quality of goods on their consumer price. With first attempts to apply dating back to the beginning of the XX century, and being finally formalized by Griliches in 1961, the method allows us to divide the observed price change into a part determined by inflationary processes and a part associated with changes in consumer qualities of goods. In foreign literature, the method has received wide coverage; it has been applied to the prices of a wide variety of goods: from consumer electronics to air tickets in the US. Currently, the method is often used to study the real estate market. At the same time, in the Russian literature there are relatively few works considering this method. In this paper, the authors attempted to apply the method to prices of consumer electronics (laptops) and used cars. Also, the authors present updated results from previously published works related to mobile phones and TVs. The application of the method showed that it allows obtaining adjusted values of price indices that ate significantly different from simple observable prices index.
International monetary policy transmission in EAEU countries
Authors: Добронравова Е.П. , Трунин П.В. 
Published: April 2024

В статье проводится анализ каналов и возможного влияния проводимой в России денежно-кредитной политики (ДКП) на экономики стран Евразийского экономического cоюза. Теоретическая литература выделяет три основные группы каналов трансмиссии: международной торговли, трудовой миграции и финансовые. Проведенное авторами исследование показало, что наблюдается значимое воздействие монетарного шока в РФ на экономики ЕАЭС. Среди основных каналов трансмиссии выделяется канал международной торговли: ужесточение ДКП в России приводит к ограничению экономической активности в странах-партнерах вследствие сокращения экспорта, при этом теоретически ожидаемого ослабления валютных курсов не выявлено. Несмотря на высокую синхронность процентных ставок, свидетельств высокой мобильности капитала для эффективной работы финансовых каналов транс-граничной трансмиссии в странах ЕАЭС не обнаружено. На основе этого можно сделать вывод, что поведение процентных ставок может быть вызвано общими инфляционными процессами, связанными с синхронизацией бизнес-циклов, вызванной усилением взаимной торговли и долгосрочными инвестициями.
The paper presents the analysis of the channels and potential impact of Russian monetary policy on the economies of Eurasian Economic Union members. Theoretical literature highlights three key groups of international transmission channels: international trade, migration of labor and financial channels. Our research demonstrates the significant impact of monetary policy shock in Russia on the economies of EAEU. International trade channel stands out as a key transmission channel: monetary tightening in Russia leads to the decrease in economic activity in the member states as a result of the reduction in exports of those countries, while currency depreciation, expected by economic theory, was not detected. Despite of synchronization of the interest rates, we couldn’t find much evidence of high capital mobility between EAEU countries, which is the main precondition on the efficiency of financial channels of international monetary transmission. This leads to the conclusion that such behavior of interest rates might occur due to the common inflationary pressures, associated with business-cycles synchronization, strengthening of mutual trade and long-term investment.
IMPLEMENTASI PROGRAM PENYEDIAAN AIR MINUM DAN SANITASI BERBASIS MASYARAKAT (PAMSIMAS) DI DESA NOEBAUN KECAMATAN NOEMUTI KABUPATEN TIMOR TENGAH UTARA
Authors: Tiza Agustinus Longa , Bifel Maria Stefany , Minggu Pionisius 
Published: April 2024

Penelitian ini berjudul Implementasi Program Penyediaan Air Minum dan Sanitasi Berbasis Masyarakat (PAMSIMAS) di Desa Noebaun Kecamatan Noemuti. Permasalahan utama yang ditemui dalam penelitian ini adalah Program Pamsimas belum sepenuhnya dirasakan mafaatnya oleh masyarakat Desa Noebaun. Hal in ditandai dengan belum tercapainya target yang ditetapkan dalam program Pamsimas dalam pemenuhuan kebutuhan air bersih bagi masyarakat. Tujuan penelitian ini adalah untuk menganalisis dan mendeskripsikan implementasi program Pamsimas di Desa Noebaun. Metode yang digunakan adalah kualitatif. Hasil penelitian menunjukan bahwa Implementasi Program Pamsimas di Desa Noebau Kecamatan Noemuti cukup berhasil baik ditinjau dari pemanfaatan sumberdaya. Komunikasi yang ada dalam pelaksanaan Program Pamsimas cukup baik baik dilihat dari saluran komunikasi yang ada, dan kecenderungan individu bersikap positif dan partisipatif dalam mendukung pelaksanaan program Pamsimas. Hal-hal yang mendukung adalah komunikasi yang berjalan baik, tanggapan masyarakat yang baik dan partisipatisipatif, pemberdayaan sumber daya yang optimal baik SDM, kewenangan maupun informasi yang ada. Hal-hal yang menghambat pelaksanaan Program Pamsimas antara lain berkaitan dengan kelangkaan sumber air baku untuk air bersih, keterbatasan pendelegasian kewenangan yang diberikan pemerintah pusat terhadap pelaksana di lapangan. Disisi lain, profesionalisme kerja para pelaku program belum otimal.
Marine Sponge Xestospongia sp.: A Promising Source for Tuberculosis Drug Development - Computational Insights into Mycobactin Biosynthesis Inhibition
Authors: Arfan Arfan , Asnawi Aiyi , Aman La Ode 
Published: April 2024

Mycobacterium tuberculosis (MTB) remains the leading cause of infection, with a significant fatality rate, owing primarily to drug resistance. MTB contains the enzyme salicylate synthase, which regulates mycobactin production to bind iron ions from the host cell, facilitating the bacteria to grow and reproduce. This study investigates the potential of marine sponges to inhibit the MTB salicylate synthase by exploiting a computational approach combining molecular docking and dynamics simulations. Forty-six compounds from Xestospongia sp. were chosen from the Marine Natural Products database. The docking results selected four compounds (CMNPD15071, CMNPD7640, CMNPD26706, and CMNPD7639) from this sponge, which provide more negative binding energy than their inhibitors (RVE). After reclassifying their interactions, such as hydrophobic and hydrogen bonds, CMNPD15071 (Sulfuric acid mono-(8-methoxy-12b-methyl-6-oxo-2,3,6,12b-tetrahydro-1H-5-oxa-benzo[k]acephenanthrylen-11-yl) ester) and CMNPD7640 (secoadociaquinone B) performed molecular dynamics simulations to assess their stability. These two compounds show a promising stability profile compared to RVE based on RMSD, RMSF, SASA, and gyration analysis. Furthermore, the binding affinity prediction of these two compounds using the MM/GBSA calculation method reveals that CMNPD15071 (-38.48 kJ/mol) had the highest affinity for binding to MTB salicylate synthase compared to RVE (-35.36 kJ/mol) and CMNPD7640 (-26.03 kJ/mol). These findings demonstrate that compounds from Xestospongia sp. can block MTB mycobactin biosynthesis by inhibiting salicylate synthase.
Nanoemulsion Mouthwash Formulation of Bajakah Tampala (Spatholobus littoralis Hassk.) Skin Extract Against Candida albicans
Authors: Hamzah Hasyrul , Gunawan Dede Reza , Pratiwi Sylvia Utami Tunjung , Bakhtiar Muh. Irham , Pratama Virgiawan Yoga , Subhan Muhammad , Maulana Riza 
Published: April 2024

Candida albicans can cause two infections in humans: superficial and systemic. The ability of C. albicans to infect the host is influenced by virulence factors and character changes so that it can fool the immune system. From the character change factor, C. albicans can form a biofilm. This study aims to determine the good concentration in inhibiting and determine the antifungal and antibiofilm activity of nanoemulsion mouthwash formulation of bajakah tampala (Spatholobus littoralis Hassk) skin extract against C. albicans. This research was conducted with an experimental method. The formulation used a spontaneous magnetic stirrer technique to make nanoemulsion preparations. Antifungal and antibiofilm tests were carried out by dilution method using a 96-well plate and a microplate reader with a wavelength of 620 nm to determine the percentage inhibition against C. albicans and determine MIC50 and MBIC50. The results showed that the nanoemulsion mouthwash formulation of S. littoralis inhibited the planktonic and biofilm of C. albicans. The concentration of 1% is expressed as MIC50 and MBIC50. Therefore, the nanoemulsion formulation of S. littoralis extract could inhibit the growth of C. albicans in the oral cavity.
A murine model of peanut-allergic asthma
Authors: Paolucci Marta , Antz Nathalie , Homère Valentine , Kolm Isabel , Kündig Thomas M. , Johansen Pål 
Published: April 2024

ObjectivesPeanut allergy is an IgE-mediated food allergy that is associated with asthma in certain patients. With increasing prevalence, its great impact on the quality of life, and a lack of treatment options, the need for new therapy options is a given. Hence, models for research and development are required. This study aimed to establish a murine model of allergic airway inflammation induced by peanut allergens.MethodsC3H mice were sensitised by intraperitoneal injections of peanut allergen extract and challenged by an intranasal application of the same extract. The assessment of airway inflammation involved the analysis of immune cells in the bronchoalveolar lavage fluid as measured by flow cytometry. Inflammatory reactions in the lung tissue were also studied by histology and quantitative PCR. Moreover, peanut-specific immune responses were studied after re-stimulation of spleen cells in vitro.ResultsSensitisation led to allergen-specific IgE, IgA, and IgG1 seroconversion. Subsequent nasal exposure led to allergic airway inflammation as manifested by structural changes such as bronchial smooth muscle hypertrophy, mucus cell hyperplasia, infiltration of eosinophil cells and T cells, as well as an upregulation of genes expressing IL-4, IL-5, IL-13, and IFN-γ. Upon re-stimulation of splenocytes with peanut allergen, increased secretion of both T-helper type 2 (Th2) and Th1 cytokines was observed.ConclusionWe successfully established a peanut-associated asthma model that exhibited many features characteristic of airway inflammation in human patients with allergic asthma. The model holds potential as a tool for investigating novel therapeutic approaches aimed at preventing the development of allergic asthma.
Evaluation of the relationship between left atrial stiffness, left ventricular stiffness, and left atrioventricular coupling index in type 2 diabetes patients: a speckle tracking echocardiography study
Authors: Dang Hai Nguyen Ngoc , Luong Thang Viet , Ho Binh Anh 
Published: April 2024

BackgroundCardiovascular complications are a leading cause of mortality and disability in individuals with diabetes mellitus (DM). Moreover, DM can directly impact the structure and function of cardiac muscle. We conducted a study to evaluate cardiac stiffness in DM patients in both the left atrium (LA) and left ventricle (LV), as well as to assess the impact of DM on the synchronization of the LA and LV, particularly within the Vietnamese population, utilizing speckle tracking echocardiography (STE).MethodsWe studied 111 research subjects divided into two groups comprising 52 patients with DM and 59 healthy individuals. All the subjects provided relevant clinical information, and echocardiography was performed to assess the indices of LA stiffness, LV stiffness, and left atrioventricular coupling index (LACI).ResultsOur study indicated that DM patients exhibited greater LA and LV stiffness than control patients. The LACI (%) in the DM group was also greater than that in the control group (17.12% ± 6.72% vs. 12.28% ± 3.96%, respectively; p &lt; 0.001). The LACI was positively correlated with the LA and LV stiffness indices. Decreased levels of LV GLS, adjusted for age, sex, blood pressure, and BMI, have emerged as identified risk factors for DM.ConclusionsLA stiffness, LV stiffness, and the LACI are greater in DM patients than in normal individuals.
Low TSH and low T3 hormone levels as a prognostic for mortality in COVID-19 intensive care patients
Authors: Sror-Turkel Or , El-Khatib Nidal , Sharabi-Nov Adi , Avraham Yaniv , Merchavy Shlomo 
Published: April 2024

IntroductionCoronavirus diasease 2019 (COVID-19) can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. The thyroid gland is a neuroendocrine organ that plays an important role in regulating immunity and metabolism. Low serum levels of thyroid hormones are common in critical disease situations. The association between low thyroid hormone levels and mortality in COVID-19 intensive care patients has yet to be studied.AimThe aim of this study is to compare thyroid hormone levels between patients in the general intensive care unit (ICU) to patients in the COVID-19 ICU.MethodsThis was a retrospective comparative study of 210 patients who were hospitalized at Ziv Medical Center in the general ICU and in the COVID-19 ICU. Clinical and demographic data were collected from patient’s electronic medical records.ResultsSerum thyroid hormone levels of Thyroid Simulating Hormone (TSH), T4, and T3 were significantly lower in COVID-19 intensive care unit patients compared to the patients from the general intensive care unit (p &lt; 0.05). The mortality rate in the COVID-19 ICU (44.4%) was higher compared to that in the general ICU (27.3%) (p &lt; 0.05). No significant statistical difference was observed between the two groups in terms of gender and recorded comorbidities of diabetes mellitus, cerebral vascular accident, kidney disease, and cancer.ConclusionsLow serum thyroid hormone levels—T3, T4, and TSH—in COVID-19 ICU patients are associated with higher mortality and could possibly be used as a prognostic factor for mortality among COVID-19 ICU patients. Thyroid hormone levels should be a part in the routine evaluation of COVID-19 ICU patients.