bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using knowledge in the world to improve patient safety: Designing affordances in health care equipment to specify a sequential “checklist”
Authors: Bakdash Jonathan Z. , Drews Frank A. 
Published: December 2011

AbstractUse of current health care equipment for medical procedures (e.g., central line insertions and central line care) is primarily dependent on the cognition of the health care worker. That is, the present design of equipment (typically numerous, separately packaged individual items) provides minimal information about the optimal order of procedure steps and no defenses against human error, such as omitting steps in procedure. In this article, we propose patient safety may be improved by redesigning equipment to integrate a “checklist” using sequencing, color coding, and visual icons. We hypothesize this reduces cognitive demand by off‐loading knowledge into the world, creating affordances that provide guidance reducing the likelihood of errors and promoting adherence to best practices. © 2011Wiley Periodicals, Inc.
Efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in patients with generalised anxiety disorder: an analysis of pooled data from three 8‐week placebo‐controlled studies
Authors: Stein Dan J. , Bandelow Borwin , Merideth Charles , Olausson Bengt , Szamosi Johan , Eriksson Hans 
Published: December 2011

ObjectiveProspectively planned pooled analysis evaluating efficacy and tolerability of acute quetiapine XR monotherapy in generalised anxiety disorder.MethodsData from three 10‐week, randomised, double‐blind, placebo‐controlled studies of similar design were analysed.ResultsAt Week 8, Hamilton Anxiety Rating Scale (HAM‐A) total score significantly improved with quetiapine XR: least squares means change −13.31, p < 0.001 (50 mg/day, n = 452), −14.39, p < 0.001 (150 mg/day, n = 673) and −12.50, p < 0.05 (300 mg/day, n = 444) versus −11.30 placebo; significant (p < 0.001, n = 665) improvements versus placebo were observed with each dose at Week 1. Significant improvements versus placebo at Week 8 are as follows: HAM‐A psychic symptom subscale, Montgomery‐Åsberg Depression Rating Scale total, Pittsburgh Sleep Quality Index global scores for all quetiapine XR doses; HAM‐A response and remission rates, HAM‐A somatic symptom subscale score, Clinical Global Impression‐Severity of Illness total score, % patients with Clinical Global Impression‐Improvement score ≤2 with quetiapine XR 50 and 150 mg/day; and Quality of Life Enjoyment and Satisfaction Questionnaire short form % maximum total score with quetiapine XR 150 mg/day. In the quetiapine XR 50, 150 and 300 mg/day and placebo groups, 13.2%, 16.5%, 24.0% and 5.4% of patients discontinued because of an adverse event, and 1.9%, 1.4%, 3.7% and 1.8% of patients experienced clinically significant changes in glucose. The most common adverse events with quetiapine XR included dry mouth, somnolence, sedation and constipation.ConclusionQuetiapine XR monotherapy reduced the symptoms of generalised anxiety disorder, with improvement from Week 1. Adverse events were consistent with the known tolerability profile of quetiapine. Copyright © 2011 John Wiley & Sons, Ltd.
Toxic effects of cypermethrin on the male reproductive system: with emphasis on the androgen receptor
Authors: Hu Jin‐xia , Li Yan‐fang , Li Jing , Pan Chen , He Zhen , Dong Hong‐yan , Xu Li‐chun 
Published: December 2011

ABSTRACTThe 15‐day intact adult male assay was used to investigate the reproductive toxicity of cypermethrin. We also evaluated the contributions of the androgen receptor (AR) to cypermethrin‐induced reproductive impairments. Sixty adult male Sprague–Dawley rats were randomly divided into five groups and treated with different doses of cypermethrin (0, 6.25, 12.5, 25 and 50 mg kg−1 per day) by oral gavage for 15 days. After the rats were sacrificed, the testes, epididymides, seminal vesicles and prostates were excised and weighed. One testis was frozen to be used for daily sperm production. Another testis was processed for AR immunohistochemical analysis and electron microscopic observation. We found that the weights of prostates were significantly decreased in cypermethrin treatment at doses of 25 and 50 mg kg−1 per day. Rats treated with cypermethrin at 50 mg kg−1 per day exhibited a significant reduction in testicular daily sperm production. Seminiferous tubule changes were noted, including atrophy and distorted seminiferous tubules, reduction and deformation of spermatogonia, spermatocyte and disordered arrangement of spermatoblasts. Ultrastructural changes were found in cypermethrin‐treated groups with disrupted cellular junctions, abnormal morphology of the nucleus, necrosis of spermatogonia spermatocytes and Sertoli cells. To clarify the possible mechanism, AR expression and the serum levels of testosterone were assayed. AR levels were significantly reduced in the rats treated with cypermethrin and the serum levels of testosterone were reduced in cypermethrin treatment at a dose of 50 mg kg−1 per day. These data suggested that cypermethrin can induce impairments of the structure of seminiferous tubules and spermatogenesis in the male rats. The impairments can be attributed to the reduced AR expression. Copyright © 2011 John Wiley & Sons, Ltd.
SOURCES OF REAL EXCHANGE RATE VOLATILITY AND INTERNATIONAL FINANCIAL INTEGRATION: A DYNAMIC GENERALISED METHOD OF MOMENTS PANEL APPROACH
Authors: Caporale Guglielmo Maria , Hadj Amor Thouraya , Rault Christophe 
Published: December 2011

AbstractThe aim of this paper is to provide some new empirical evidence on the determinants of volatility of real exchange rates in emerging countries, focusing on the role of international financial integration in particular. A reduced‐form model is estimated using the generalised method of moments for dynamic panels over the period 1979–2004 for a sample of 39 developing countries grouped into three regions (Latin America, Asia and MENA). Our findings suggest that different types of shocks (external, real and monetary) can account for the volatility of real exchange rates in emerging economies, with international financial integration being a major driving force. Therefore, financial liberalisation and integration should be pursued only gradually in emerging countries. Copyright © 2011 John Wiley & Sons, Ltd.
Long‐term effects of coping with extreme stress: Longitudinal study of Vietnam‐era repatriated prisoners of war
Authors: Kaiser Anica Pless , Park Crystal L. , King Lynda A. , King Daniel W. , Schuster Jennifer , Spiro Avron , Moore Jeffrey L. , Kaloupek Danny G. , Keane Terence M. 
Published: December 2011

AbstractCaptivity stressors and coping strategies were assessed shortly after the repatriation of Vietnam‐era prisoners of war, and physical and mental health were assessed almost three decades later. Given research on coping goodness‐of‐fit, specifically the extent to which coping effects depend on situational controllability, we proposed that endorsement of the usefulness of avoidance‐based strategies in captivity would be predictive of better later‐life health. Findings indicated that approach‐based and avoidance‐based coping both moderated the link between physical torture and later physical health functional status, whereas approach‐based coping moderated the link between injuries at capture and later mental health. Specifically, greater endorsement of avoidance‐based coping was associated with better long‐term physical health for prisoners who experienced the most physical torture. Lower endorsement of approach‐based coping was associated with better long‐term mental health for prisoners who reported the most injuries at the time of capture.
Comprehensive H2/O2 kinetic model for high‐pressure combustion
Authors: Burke Michael P. , Chaos Marcos , Ju Yiguang , Dryer Frederick L. , Klippenstein Stephen J. 
Published: December 2011

AbstractAn updated H2/O2 kinetic model based on that of Li et al. (Int J Chem Kinet 36, 2004, 566–575) is presented and tested against a wide range of combustion targets. The primary motivations of the model revision are to incorporate recent improvements in rate constant treatment and resolve discrepancies between experimental data and predictions using recently published kinetic models in dilute, high‐pressure flames.Attempts are made to identify major remaining sources of uncertainties, in both the reaction rate parameters and the assumptions of the kinetic model, affecting predictions of relevant combustion behavior. With regard to model parameters, present uncertainties in the temperature and pressure dependence of rate constants for HO2 formation and consumption reactions are demonstrated to substantially affect predictive capabilities at high‐pressure, low‐temperature conditions. With regard to model assumptions, calculations are performed to investigate several reactions/processes that have not received much attention previously. Results from ab initio calculations and modeling studies imply that inclusion of H + HO2 = H2O + O in the kinetic model might be warranted, though further studies are necessary to ascertain its role in combustion modeling. In addition, it appears that characterization of nonlinear bath‐gas mixture rule behavior for H + O2(+ M) = HO2(+ M) in multicomponent bath gases might be necessary to predict high‐pressure flame speeds within ∼15%.The updated model is tested against all of the previous validation targets considered by Li et al. as well as new targets from a number of recent studies. Special attention is devoted to establishing a context for evaluating model performance against experimental data by careful consideration of uncertainties in measurements, initial conditions, and physical model assumptions. For example, ignition delay times in shock tubes are shown to be sensitive to potential impurity effects, which have been suggested to accelerate early radical pool growth in shock tube speciation studies. In addition, speciation predictions in burner‐stabilized flames are found to be more sensitive to uncertainties in experimental boundary conditions than to uncertainties in kinetics and transport. Predictions using the present model adequately reproduce previous validation targets and show substantially improved agreement against recent high‐pressure flame speed and shock tube speciation measurements. Comparisons of predictions of several other kinetic models with the experimental data for nearly the entire validation set used here are also provided in the Supporting Information. © 2011 Wiley Periodicals, Inc. Int J Chem Kinet 44: 444–474, 2012
A double‐blind study on clonazepam in patients with burning mouth syndrome
Authors: Heckmann Siegfried M. , Kirchner Elena , Grushka Miriam , Wichmann Manfred G. , Hummel Thomas 
Published: December 2011

AbstractObjectives/Hypothesis:In the treatment of burning mouth syndrome (BMS), various approaches have been tried with equivocal results. The aim of the present randomized clinical trial was to determine the efficacy of clonazepam, a GABA agonist designed as an antiepileptic drug that exerts the typical effects of benzodiazepines.Study Design:Randomized clinical trial.Methods:Twenty patients with idiopathic BMS were carefully selected. Clonazepam (0.5 mg/day, n = 10) or placebo (lactose, n = 10) were randomly assigned to the patients.Results:Patients on clonazepam significantly improved in pain ratings (P < .001). These changes were less pronounced in the placebo group (P < .11). No significant changes were observed in a mood scale (P = .56) or for depression scores (P = .56). Taste test and salivary flow increased over sessions, but were not different between groups (P = .83 and P = .06, respectively).Conclusions:Clonazepam appears to have a positive effect on pain in BMS patients. Laryngoscope, 2012
Histopathological analysis of a 15‐year user of an auditory brainstem implant
Authors: Otto Steven R. , Moore Jean , Linthicum Fred , Hitselberger William , Brackmann Derald , Shannon Robert V. 
Published: December 2011

AbstractAuditory brainstem implants (ABIs) can provide highly beneficial hearing sensations to individuals deafened by bilateral vestibular schwannomas (neurofibromatosis type 2). Relatively little is known about the status of stimulated neurons after long‐term ABI use. Direct examination of the cochlear nuclear complex (CN) of one 5‐year ABI user indicated no deleterious effect. Recently, we examined the brainstem of a patient who used his ABI daily for 15 years with excellent performance. There was good preservation of CN cell size, morphology, and packing density, a very favorable sign considering that a number of infants are now receiving ABIs.
3 Tesla turbo‐FLASH magnetic resonance imaging of deglutition
Authors: Amin Milan R. , Lazarus Cathy L. , Pai Vinay M. , Mulholland Thomas P. , Shepard Timothy , Branski Ryan C. , Wang Edwin Y. 
Published: December 2011

AbstractObjectives/Hypothesis:In this article we describe a methodology for obtaining high‐quality dynamic magnetic resonance imaging (MRI) sequences of the swallow sequence in healthy volunteers. The study includes comparison to previous work done in our lab using a 1.5 Tesla (T) magnet.Study Design:Case series.Methods:Three healthy volunteers underwent turbo‐fast low angle shot MRI at 3T while swallowing liquid boluses delivered via intravenous tubing to the oral cavity. Imaging was performed in the sagittal and axial planes.Results:Imaging provided by this sequence provided high temporal resolution, with the ability to depict deglutition in the axial and sagittal planes. Comparison with imaging at 1.5T demonstrated benefits in temporal resolution and signal‐to‐noise. Anatomic information provided differed from comparative videofluoroscopy.Conclusions:MRI of swallowing using the described technique is reliable and provides a unique evaluation of the swallowing sequence. Laryngoscope, 2012
Treatment of hereditary hemorrhagic telangiectasia with submucosal and topical bevacizumab therapy
Authors: Karnezis Tom T. , Davidson Terence M. 
Published: December 2011

AbstractObjective/Hypothesis:Bevacizumab delivered as a submucosal and topical intranasal therapy effectively controls hereditary hemorrhagic telangiectasia (HHT)‐associated epistaxis.Study Design:Prospective institutional review board‐approved study.Methods:Between December 2009 and December 2010, 19 patients with HHT‐associated epistaxis were treated with 100 mg of intranasal submucosal bevacizumab. Following treatment, patients were contacted monthly to report their epistaxis severity score (ESS) for 9 or more months after their initial treatment. If a patient had a significant increase in their ESS, they were offered treatment with 100 mg of topical bevacizumab, administered via a metered dose atomizer. All treatments were recorded.Results:All 19 patients had a postinjection ESS documented through 9 months, whereas 17 patients had completed ESS data between months 10 and 12. Six of the 19 patients received eight additional 100 mg of topical bevacizumab treatments because they had an increase in their ESS. Results demonstrated a mean preinjection ESS of 8.12, with an ESS nadir of 2.00 reached at 2 months following submucosal injection (P < 0.0001). Over the following 12 months, the mean ESS steadily increased back to a maximum of 3.6 reached at 11 months following injection (P < .0001).Conclusions:Intranasal submucosal bevacizumab effectively treats HHT‐associated epistaxis for up to 12 months following treatment.
Split liver transplantation using extended right grafts: The natural history of segment 4 and its impact on early postoperative outcomes#
Authors: Sepulveda Ailton , Scatton Olivier , Tranchart Hadrien , Gouya Hervé , Perdigao Fabiano , Stenard Fabien , Bernard Denis , Conti Filomena , Calmus Yvon , Soubrane Olivier 
Published: December 2011

Abstract
Split liver transplantation (SLT) using extended right grafts is associated with complications related to ischemia of hepatic segment 4 (S4), and these complications are associated with poor outcomes. We retrospectively analyzed 36 SLT recipients so that we could assess the association of radiological, biological, and clinical features with S4 ischemia. The overall survival rates were 84.2%, 84.2%, and 77.7% at 1, 3, and 5 years, respectively. The recipients were mostly male (24/36 or 67%) and had a median age of 52 years (range = 13-63 years), a median body mass index of 22.9 kg/m2 (range = 17.3-29.8 kg/m2), and a median graft-to-recipient weight ratio of 1.3% (range = 0.9%-1.9%). S4-related complications were diagnosed in 22% of the patients (8/36) with a median delay of 22 days (range = 10-30 days). Secondary arterial complications were seen in 3 of these patients and led to significantly decreased graft survival in comparison with the graft survival of patients without complications (50.0% versus 85.6%, P = 0.017). Patients developing S4-related complications had significantly elevated aspartate aminotransferase (AST) levels (>1000 IU/L) on postoperative day (POD) 1 and elevated gamma-glutamyl transpeptidase (GGT) levels (>300 IU/L) on PODs 7 and 10 (P < 0.05). These AST and GGT elevations conferred a significantly high risk of developing these complications (odds ratio = 42, 95% confidence interval = 4-475, P < 0.05). The ischemic volume of S4 was extremely variable (0%-95%) and did not correlate with S4-related complications. In conclusion, our results suggest that S4-related complications are risk factors for worse graft survival, and the development of these complications can be anticipated by the early identification of a specific biological profile and a routine radiological examination. Liver Transpl 18:413–422, 2012. © 2011 AASLD.
Metallization of a Genetically Engineered Polypeptide
Authors: Carlsen Autumn , Higashiya Seiichiro , Topilina Natasha I. , Dunn Kathleen A. , Geer Robert E. , Eisenbraun Eric T. , Kaloyeros Alain E. , Welch John T. 
Published: December 2011

AbstractRecently, well‐ordered biological materials have been exploited to pattern inorganic nanoparticles into linear arrays that are of particular interest for nanoelectronic applications. In this work, a de novo designed E. coli‐expressed polypeptide (previously shown to form highly rectilinear, β‐sheet‐containing structures) operates as a template for divalent metal cations. EDX and TEM analysis verify the attachment of platinum ions to the histidine‐rich fibril surface, which was designed specifically to facilitate attachment of chemical moieties. Following chemical reduction, TEM further confirms the formation of localized zero‐valent metal aggregates with sub‐nanometer interparticle spacing.magnified image
Characterization of a Hierarchical Network of Hyaluronic Acid/Gelatin Composite for use as a Smart Injectable Biomaterial
Authors: Heris Hossein K. , Rahmat Meysam , Mongeau Luc 
Published: December 2011

AbstractHybrid HA/Ge hydrogel particles are embedded in a secondary HA network to improve their structural integrity. The internal microstructure of the particles is imaged through TEM. CSLM is used to identify the location of the Ge molecules in the microgels. Through indentation tests, the Young's modulus of the individual particles is found to be 22 ± 2.5 kPa. The overall shear modulus of the composite is 75 ± 15 Pa at 1 Hz. The mechanical properties of the substrate are found to be viable for cell adhesion. The particles' diameter at pH = 8 is twice that at pH = 5. The pH sensitivity is found to be appropriate for smart drug delivery. Based on their mechanical and structural properties, HA–Ge hierarchical materials may be well suited for use as injectable biomaterials for tissue reconstruction.magnified image
The magnetic field dependence of water T1 in tissues
Authors: Diakova Galina , Korb Jean‐Pierre , Bryant Robert G. 
Published: December 2011

AbstractThe magnetic field dependence of the composite 1H2O nuclear magnetic resonance signal T1 was measured for excised samples of rat liver, muscle, and kidney over the field range from 0.7 to 7 T (35–300 MHz) with a nuclear magnetic resonance spectrometer using sample‐shuttle methods. Based on extensive measurements on simpler component systems, the magnetic field dependence of T1 of all tissues studied are readily fitted at Larmor frequencies above 1 MHz with a simple relaxation equation consisting of three contributions: a power law, A*ω−0.60 related to the interaction of water with long‐lived‐protein binding sites, a logarithmic term B*τd*log(1+1/(ωτd)2) related to water diffusion at macromolecular interfacial regions, and a constant term associated with the high frequency limit of water‐spin‐lattice relaxation. The parameters A and B include the concentration and surface area dependences respectively. The logarithmic diffusion term becomes significant at high magnetic fields and is consistent with rapid translational dynamics at macromolecular surfaces. The data are fitted well with translational correlation times of approximately 15 ps for human brain white matter, but with a B value three times larger than gray matter tissues. This analysis suggests that the water‐surface translational correlation time is approximately three times longer than in gray matter. Magn Reson Med, 2012. © 2011 Wiley Periodicals Inc.
Italian corporate foundations and the challenge of multiple stakeholder interests
Authors: Pedrini Matteo , Minciullo Marco 
Published: December 2011

AbstractThis article investigates corporate foundations, a specific expression of corporate philanthropy that is narrowly considered in the literature. We aim to verify whether the interests of the founder firm are significant antecedents of the model, activities, and issues addressed by the related foundation. Data were collected through a survey of seventy Italian corporate foundations, representing 59.8 percent of the total number of such foundations based in Italy. The analysis identified three clusters of corporate foundations—granter, expert, and edifier. Research demonstrates that through these clusters, the interests pursued by founder firms have a significant influence on integration between firms and corporate foundations and on the foundations' activities.
DBX‐1 – A Lead Free Replacement for Lead Azide
Authors: Fronabarger John W. , Williams Michael D. , Sanborn William B. , Bragg Jon G. , Parrish Damon A. , Bichay Magdy 
Published: December 2011

AbstractEfforts directed towards creating new environmentally friendly replacements for existing primary explosives have resulted in development of copper(I) 5‐nitrotetrazolate (DBX‐1). The chemical and physical properties of this material have been extensively investigated and it appears that DBX‐1 is a suitable drop‐in replacement for lead azide in a variety of ordnance applications. DBX‐1 is easily prepared, has excellent thermal stability and has safety and performance properties which are equivalent to or exceed those for lead azide. A program to qualify DBX‐1 for military use per NAVSEAINST 8020.5C has recently been completed and data has been forwarded to NSWC‐IH for submission to Naval Sea Systems Command.