bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue residue concentrations of organohalogens and trace elements in adult Pacific salmon returning to the Fraser River, British Columbia, Canada
Authors: Kelly Barry C , Ikonomou Michael G , MacPherson Nancy , Sampson Tracy , Patterson David A , Dubetz Cory 
Published: November 2010

Abstract
We report measured concentrations of organohalogens and trace elements in muscle and eggs of returning wild Pacific sockeye and chinook salmon during their 2007 migration through the Fraser River watershed in Canada. Chemical analyses revealed the presence of ppb to ppm levels of a wide variety of contaminants in these fish, including polychlorinated biphenyls (PCBs); polychlorinated dibenzo-p-dioxins (PCDDs); polychlorinated dibenzofurans (PCDFs); polybrominated diphenyl ethers (PBDEs); organochlorine pesticides (OCPs) such as DDTs, hexachlorocyclohexanes (HCHs), octachlorostyrene, and cyclodienes; and Hg, As, Cd, Pb, and several other trace elements. Body weights and flesh lipid contents declined during upstream migration, resulting in significantly higher (p &lt; 0.05) lipid-normalized concentrations of lipophilic organohalogens (PCBs, PCDD/Fs, pesticides) in those spawning salmon. Postmigration magnification factors (MFs) of organohalogens (0.1–10) were comparable to previous observations and model predictions. MFs generally increased with increasing hydrophobicity (KOW). For example, MFs of tetra- and pentachlorobenzenes and HCH isomers (log KOW range: 3.8–5) were relatively low (between 0.1 and 1.7) compared with those of more lipophilic compounds (log KOW &gt; 6) such as PCBs, DDTs, and mirex (MFs between 5 and 10). Lipid-normalized muscle:egg ratios in female salmon, which varied between 0.1 and 8, also exhibited a positive relationship with chemical KOW. The results indicate that lipophilic compounds (KOW &gt; 106) can be magnified in flesh lipids of Pacific salmon during spawning migration, but maternal transfer kinetics (deposition to eggs) of those chemicals are relatively slow compared with less hydrophobic compounds. 2,3,7,8-TCDD toxic equivalents (ΣTEQs) in eggs of these spawning salmon, calculated using WHO toxic equivalency factors (WHO-TEFs) for fish health, in some cases exceeded the 0.3 pg·g−1 threshold level associated with 30% salmonid egg mortality, indicating the potential for reproductive impacts in Fraser River salmon populations. Environ. Toxicol. Chem. 2011;30:367–376. © 2010 SETAC
New metric for stereo image quality assessment based on HVS
Authors: Yang Jiachen , Hou Chunping , Xu Ran , Lei Jianjun 
Published: November 2010

AbstractStereo image is regarded as an important trend of image technology, and there is an increasing need to develop efficient measures for stereo image quality evaluation. By analyzing the main properties of human visual system that is related to stereo image, a new metric based on human visual systems (HVSs) for stereo image quality assessment is proposed in this article. This method assesses stereo images from the perspective of image quality and stereo sense. The experimental results are presented to show that the proposed metric provides results consistent with the subjective assessment and thus can be employed to reflect image quality and stereo sense. © 2010 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 20, 301–307, 2010
Automatic gait recognition based on probabilistic approach
Authors: Nizami Imran Fareed , Hong Sungjun , Lee Heesung , Lee Byungyun , Kim Euntai 
Published: November 2010

AbstractA simple probabilistic method for online video based human identification is introduced in this article. The proposed method is based on a modified version of Motion Silhouette images (MSI) and recursive probability accumulation. The modified version of MSI is named the Moving Motion Silhouette Image (MMSI). Identification probability is accumulated recursively in a Bayesian framework to draw a single conclusion from the whole gait sequence. The probability is named the accumulated posterior probability (APP) and denotes the probability based on all the information available up to now. The proposed method is tested on the well‐known publicly available NLPR and SOTON gait databases. The experimental results demonstrate the effectiveness of the proposed algorithm and indicate the fact that using MMSI and APP for information fusion yields higher recognition rates as compared to previous gait recognition systems. © 2010 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 20, 400–408, 2010
Color edge detection using multiscale quaternion convolution
Authors: Xu Jiangyan , Ye Linning , Luo Wang 
Published: November 2010

AbstractThis article presents a novel color edge detection algorithm based on quaternion convolution. A set of multiscale quaternion masks are presented, and the filtered results are multiplied at adjacent scales using dot product to enhance the edge structures while diluting noise. Experimental results show that the proposed method is efficient and robust for color images. © 2010 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 20, 354–358, 2010
Determination of yarn production characteristics using image processing
Authors: Carvalho Vítor H. , Belsley Michael S. , Vasconcelos Rosa M. , Soares Filomena O. 
Published: November 2010

AbstractThis article describes a low‐cost image acquisition and processing system, which measures several yarn production characteristics, namely, the fibers twist orientation, the folded yarn twist step, the folded yarn twist orientation, and the existence of single (nonfolded yarn) or multiple cables (folded yarn). The imaging hardware consists of a USB web camera coupled to an analog microscope and a monochromatic light source. The acquired images are analyzed using custom designed software based on the IMAQ Vision image program from National Instruments. A full description of the developed image processing tool is presented, together with several experimental results. The results obtained are consistent with information deduced from high‐resolution images acquired using an electron microscope. © 2010 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 20, 391–399, 2010
A virtual teleconferencing system based on face detection and 3D animation in a low‐bandwidth environment
Authors: Liu Yi‐Chih , Wang Sheng‐De 
Published: November 2010

AbstractIn this article, we proposed a novel teleconferencing system that combines a facial muscle model and the techniques of face detection and facial feature extraction to synthesize a sequence of life‐like face animation. The proposed system can animate realistic 3D face images in a low‐bandwidth environment to support virtual videoconferencing. Based on the technique of feature extraction, a face detection algorithm for the virtual conferencing system is proposed in this article. In the proposed face detection algorithm, the YCbCr skin color model is used to detect the possible face area of the image; the feature points of the face is determined by using the symmetry property of the face and the gray level characteristics of the eyes and the mouth. According to the positions of the feature points on a facial image, we can compute the transformation values of the feature points. These values will then be sent via a network from the sender's side to the receiver's side frame by frame. We can synthesize the realistic facial animations on the receiver's side based on these. Experimental results show that the proposed system can achieve a practical animated face‐to‐face virtual conference with good facial expressions and a low‐bandwidth requirement. © 2010 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 20, 323–332, 2010
Associations between dietary flavonoid intakes and bone health in a scottish population
Authors: Hardcastle Antonia C , Aucott Lorna , Reid David M , Macdonald Helen M 
Published: November 2010

Abstract
Flavonoids are bioactive polyphenols found particularly in fruit and vegetables, but little is known about their role in bone health in humans. The aim of this observational study was to investigate whether dietary flavonoid intake was associated with bone mineral density (BMD) and bone resorption in a large group of perimenopausal Scottish women. Over 3000 women completed a food frequency questionnaire as part of an osteoporosis screening study. The diets were analyzed for flavonoid intake using a food composition database. BMD was measured at the femoral neck (FN) and lumbar spine (LS) by dual-energy X-ray absorptiometry (DXA). Free pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high-performance liquid chromatography (HPLC) in second early morning fasted urine samples. The mean flavonoid intake of the diet was 307 ±199 mg/d. The catechin family contributed the most to flavonoid intakes (55%), and the flavones the least (&lt;1%). Associations were found between energy-adjusted total flavonoid intakes and BMD at the FN and LS (FN r = 0.054, LS r = 0.036, p ≤ .05). Annual percent change in BMD was associated with intakes of procyanidins and catechins (p ≤ .05), and flavanones were negatively associated with bone-resorption markers (PYD r = −0.049, DPD r = –0.057, p ≤ .001). These associations were still seen after adjusting for confounders. It is concluded that dietary flavonoid intakes are associated with BMD, supporting the evidence from animal and cellular studies. © 2011 American Society for Bone and Mineral Research.
Serum uric acid is associated with bone health in older men: A cross-sectional population-based study
Authors: Nabipour Iraj , Sambrook Philip N , Blyth Fiona M , Janu Margaret R , Waite Louise M , Naganathan Vasi , Handelsman David J , Le Couteur David G , Cumming Robert G , Seibel Markus J 
Published: November 2010

Abstract
Serum uric acid (UA) is a strong endogenous antioxidant. Since oxidative stress has been linked to osteoporosis, we examined the association between serum UA levels and bone mineral density (BMD), prevalent vertebral and nonvertebral fractures, and laboratory measures such as calcitropic hormones and bone turnover marker levels. This cross-sectional analysis consisted of 1705 community-dwelling men aged 70 years or over who participated in the baseline part of the Concord Health and Ageing in Men Project (CHAMP), a population-based study of older men in Sydney, Australia. BMD at all sites was significantly higher among men with serum UA levels above the group median than among men with UA levels below the median. In multiple regression analyses adjusted for potential confounders, serum UA remained associated with BMD at all sites (β = 0.12 to 0.14, p &lt; .001), serum calcium (β = 0.11, p = .001), parathyroid hormone (β = 0.09, p = .002), 25-hydroxyvitamin D (β = 0.09, p = .005), and was negatively associated with urinary excretion amino-terminal cross-linked telopeptide of type 1 collagen (β = –0.09, p = .006). Overall, serum UA accounted for 1.0% to 1.44% of the variances in BMD (R2 = 0.10 to 0.22). In multiple logistic regression analyses, above-median serum UA levels were associated with a lower prevalence of osteoporosis at the femoral neck [odds ratio (OR) = 0.42, 95% confidence interval (CI) 0.22–0.81, p = .010) and lumbar spine (OR = 0.44, 95% CI 0.23–0.86, p = .016) and a lower prevalence of vertebral (OR = 0.62, 95% CI 0.43–0.91, p = .015) and nonvertebral (OR = 0.51, 95% CI 0.29–0.89, p = .018) fractures. In conclusion, higher serum UA levels are associated with higher BMD at all skeletal sites and with a lower prevalence of vertebral and nonvertebral fractures in older men. © 2011 American Society for Bone and Mineral Research.
Oral bisphosphonates and risk of subtrochanteric or diaphyseal femur fractures in a population-based cohort
Authors: Kim Seo Young , Schneeweiss Sebastian , Katz Jeffrey N , Levin Raisa , Solomon Daniel H 
Published: November 2010

Abstract
Bisphosphonates are the primary therapy for postmenopausal and glucocorticoid-induced osteoporosis. Case series suggest a potential link between prolonged use of bisphosphonates and low-energy fracture of subtrochanteric or diaphyseal femur as a consequence of oversuppression of bone resorption. Using health care utilization data, we conducted a propensity score–matched cohort study to examine the incidence rates (IRs) and risk of subtrochanteric or diaphyseal femur fractures among oral bisphosphonate users compared with raloxifene or calcitonin users. A Cox proportional hazards model evaluated the risk of these fractures associated with duration of osteoporosis treatment. A total of 104 subtrochanteric or diaphyseal femur fractures were observed among 33,815 patients. The estimated IR of subtrochanteric or diaphyseal femur fractures per 1000 person-years was 1.46 [95% confidence interval (CI) 1.11–1.88] among the bisphosphonate users and 1.43 (95% CI 1.06–1.89) among raloxifene/calcitonin users. No significant association between bisphosphonate use and subtrochanteric or diaphyseal femur fractures was found [hazard ratio (HR) = 1.03, 95% CI 0.70–1.52] compared with raloxifene/calcitonin. Even with this large study size, we had little precision in estimating the risk of subtrochanteric or diaphyseal femur fractures in patients treated with bisphosphonates for longer than 5 years (HR = 2.02, 95% CI 0.41–10.00). The occurrence of subtrochanteric or diaphyseal femur fracture was rare. There was no evidence of an increased risk of subtrochanteric or diaphyseal femur fractures in bisphosphonate users compared with raloxifene/calcitonin users. However, this study cannot exclude the possibility that long-term bisphosphonate use may increase the risk of these fractures. © 2011 American Society for Bone and Mineral Research.
Once-yearly zoledronic acid and days of disability, bed rest, and back pain: Randomized, controlled HORIZON Pivotal Fracture Trial
Authors: Cauley Jane A , Black Dennis , Boonen Steven , Cummings Steven R , Mesenbrink Peter , Palermo Lisa , Man Zulema , Hadji Peyman , Reid Ian R ,   on behalf of the HORIZON Pivotal Fracture Group
Published: November 2010

Abstract
The objective of this study was to determine the effect of once-yearly zoledronic acid on the number of days of back pain and the number of days of disability (ie, limited activity and bed rest) owing to back pain or fracture in postmenopausal women with osteoporosis. This was a multicenter, randomized, double-blind, placebo-controlled trial in 240 clinical centers in 27 countries. Participants included 7736 postmenopausal women with osteoporosis. Patients were randomized to receive either a single 15-minute intravenous infusion of zoledronic acid (5 mg) or placebo at baseline, 12 months, and 24 months. The main outcome measures were self-reported number of days with back pain and the number of days of limited activity and bed rest owing to back pain or a fracture, and this was assessed every 3 months over a 3-year period. Our results show that although the incidence of back pain was high in both randomized groups, women randomized to zoledronic acid experienced, on average, 18 fewer days of back pain compared with placebo over the course of the trial (p = .0092). The back pain among women randomized to zoledronic acid versus placebo resulted in 11 fewer days of limited activity (p = .0017). In Cox proportional-hazards models, women randomized to zoledronic acid were about 6% less likely to experience 7 or more days of back pain [relative risk (RR) = 0.94, 95% confidence interval (CI) 0.90–0.99] or limited activity owing to back pain (RR = 0.94, 95% CI 0.87–1.00). Women randomized to zoledronic acid were significantly less likely to experience 7 or more bed-rest days owing to a fracture (RR = 0.58, 95% CI 0.47–0.72) and 7 or more limited-activity days owing to a fracture (RR = 0.67, 95% CI 0.58–0.78). Reductions in back pain with zoledronic acid were independent of incident fracture. Our conclusion is that in women with postmenopausal osteoporosis, a once-yearly infusion with zoledronic acid over a 3-year period significantly reduced the number of days that patients reported back pain, limited activity owing to back pain, and limited activity and bed rest owing to a fracture. © 2011 American Society for Bone and Mineral Research.
Functional relevance of the BMD-associated polymorphism rs312009: Novel Involvement of RUNX2 in LRP5 transcriptional regulation
Authors: Agueda Lídia , Velázquez-Cruz Rafael , Urreizti Roser , Yoskovitz Guy , Sarrión Patricia , Jurado Susana , Güerri Roberto , Garcia-Giralt Natàlia , Nogués Xavier , Mellibovsky Leonardo , Díez-Pérez Adolfo , Marie Pierre J , Balcells Susana , Grinberg Daniel 
Published: November 2010

Abstract
LRP5 is an osteoporosis susceptibility gene. Association analyses reveal that individual single-nucleotide polymorphisms (SNPs) determine variation in bone mineral density (BMD) among individuals as well as fracture risk. In a previous study, we identified a lumbar spine BMD-associated SNP, rs312009, located in the LRP5 5' region. A RUNX2 binding site was identified in this region by gel-shift experiments. Here we test the functionality of this SNP and examine whether RUNX2 is indeed a regulator of LRP5 expression. Gene reporter assays were used to test rs312009 functionality. Bioinformatic predictive tools and gel-shift and gene reporter assays were used to identify and characterize additional RUNX2 binding elements in the 3.3-kb region upstream of LRP5. Allelic differences in the transcriptional activity of rs312009 were observed in two osteoblastic cell lines, the T allele being a better transcriber than the C allele. RUNX2 cotransfection in HeLa cells revealed that the LRP5 5' region responded to RUNX2 in a dose-dependent manner and that the previously identified RUNX2 binding site participated in this response. Also, RUNX2 inhibition by RNAi led to nearly 60% reduction of endogenous LRP5 mRNA in U-2 OS cells. Four other RUNX2 binding sites were identified in the 5' region of LRP5. Luciferase experiments revealed the involvement of each of them in the RUNX2 response. The allelic differences observed point to the involvement of rs312009 as a functional SNP in the observed association. To our knowledge, this is the first time that the direct action of RUNX2 on LRP5 has been described. This adds evidence to previously described links between two important bone-regulating systems: the RUNX2 transcription-factor cascade and the Wnt signaling pathway. © 2011 American Society for Bone and Mineral Research.
Unique roles of phosphorus in endochondral bone formation and osteocyte maturation
Authors: Zhang Rong , Lu Yongbo , Ye Ling , Yuan Baozhi , Yu Shibin , Qin Chunlin , Xie Yixia , Gao Tian , Drezner Marc K , Bonewald Lynda F , Feng Jian Q 
Published: November 2010

Abstract
The mechanisms by which inorganic phosphate (Pi) homeostasis controls bone biology are poorly understood. Here we used Dmp1 null mice, a hypophosphatemic rickets/osteomalacia model, combined with a metatarsal organ culture and an application of neutralizing fibroblast growth factor 23 (FGF-23) antibodies to gain insight into the roles of Pi in bone biology. We showed (1) that abnormal bone remodeling in Dmp1 null mice is due to reduced osteoclast number, which is secondary to a reduced ratio of RANKL/OPG expressed by osteoclast supporting cells and (2) that osteoblast extracellular matrix mineralization, growth plate maturation, secondary ossification center formation, and osteoblast differentiation are phosphate-dependent. Finally, a working hypothesis is proposed to explain how phosphate and DMP1 control osteocyte maturation. © 2011 American Society for Bone and Mineral Research.
Activation of c-Jun NH2-terminal kinase 1 increases cellular responsiveness to BMP-2 and decreases binding of inhibitory Smad6 to the type 1 BMP receptor
Authors: Liu Hui , Liu Yunshan , Viggeswarapu Manjula , Zheng Zhaomin , Titus Louisa , Boden Scott D 
Published: November 2010

Abstract
Bone morphogenetic protein 2 (BMP-2) plays a critical role in the differentiation of precursor cells and has been approved for clinical application to induce new bone formation. To date, unexpectedly high doses of recombinant BMP-2 have been required to induce bone healing in humans. Thus, enhancing cellular responsiveness to BMP-2 potentially has critically important clinical implications. BMP responsiveness may be modulated in part by cross-talk with other signaling pathways, including mitogen-activated protein kinases (MAPKs). c-Jun NH2-terminal kinase (JNK) is a MAPK that has been reported to be required for late-stage differentiation of preosteoblasts and BMP-2-induced differentiation of preosteoblasts and pleuripotent cells. In this study we determined that MC3T3-E1-clone 24 cells (MC-24) can be induced by BMP-2 to differentiate into mineralizing osteoblast cultures. Using this inducible system, we employed both JNK loss-of-function and gain-of-function reagents to make three key observations: (1) JNK is required for phosphorylation of Smad1 by BMP-2 and subsequent activation of Smad1 signaling and osteoblast differentiation, (2) JNK1, but not JNK2, is required for BMP-2-induced formation of mineralized nodules, and (3) JNK1 activation decreases binding of inhibitory Smad6 to the type I BMP receptor (BMPR-I) and reciprocally increases binding of Smad1, both observations that would increase responsiveness to BMP-2. Understanding this and other pathways that lead to increased cellular responsiveness to BMPs could greatly aid more cost-effective and safe clinical delivery of these important molecules. © 2011 American Society for Bone and Mineral Research.
Predictive values of neutrophil CD64 expression compared with interleukin‐6 and C‐reactive protein in early diagnosis of neonatal sepsis
Authors: Dilli Dilek , Ogˇuz Ş. Suna , Dilmen Ugˇur , Köker M. Yavuz , Kızılgün Murat 
Published: November 2010

AbstractBackground: Despite major advances in the management of newborn infants, neonatal sepsis (NS) remain important causes of neonatal morbidity and mortality in the newborn, mainly among preterm and low birth weight infants. Objective: The aim of this study was to investigate the usefulness of neutrophil CD64 expression alone and together with other infection markers in NS. Methods: Peripheral blood samples were taken from 109 neonates, who were categorized into three groups: proven or clinical sepsis (n=35); disease without infection (n=42); and healthy controls (n=32). Complete blood count with differential, interleukin‐6 (IL‐6), C‐reactive protein (CRP), and cell surface expression of CD64 on neutrophils have been evaluated in a prospective manner as a diagnostic aid for NS. Results: Expression of CD64 was significantly enhanced in neonates with sepsis compared with newborns with disease without infection and healthy controls (P=0.001 and P=0.001, respectively). Cutoff values of IL‐6, CRP, CD64MFI, and CD64i were 24.9 pg/ml, 4.05 mg/l, 87.7, and 4.39, respectively. Sensitivity–negative predictive values of IL‐6, CRP, and CD64MFI/CD64i were 80.0–90.6%, 80.0–88.8%, and 88.6–94.0%, respectively. Combining all three tests increased the sensitivity to 100%; however, specificity and positive predictive value decreased to 62.1 and 55.5%, respectively. Conclusions: CD64 might be used either alone or combined with IL‐6 and CRP for early diagnosis of NS. The advantages of CD64 when compared with IL‐6 and CRP are rapid quantitation, very small blood volume required, and easy handling. J. Clin. Lab. Anal. 24:363–370, 2010. © 2010 Wiley‐Liss, Inc.