bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survivorship Care for People Affected by Advanced or Metastatic Cancer: MASCC-ASCO Standards and Practice Recommendations
Authors: Hart Nicolas H. , Nekhlyudov Larissa , Smith Thomas J. , Yee Jasmine , Fitch Margaret I. , Crawford Gregory B. , Koczwara Bogda , Ashbury Fredrick D. , Lustberg Maryam B. , Mollica Michelle , Smith Andrea L. , Jefford Michael , Chino Fumiko , Zon Robin , Agar Meera R. , Chan Raymond J. 
Published: April 2024

PURPOSE People with advanced or metastatic cancer and their caregivers may have different care goals and face unique challenges compared with those with early-stage disease or those nearing the end of life. These Multinational Association for Supportive Care in Cancer (MASCC)-ASCO standards and practice recommendations seek to establish consistent provision of quality survivorship care for people affected by advanced or metastatic cancer. METHODS A MASCC-ASCO expert panel was formed. Standards and recommendations relevant to the provision of quality survivorship care for people affected by advanced or metastatic cancer were developed through conducting (1) a systematic review of unmet supportive care needs; (2) a scoping review of cancer survivorship, supportive care, and palliative care frameworks and guidelines; and (3) an international modified Delphi consensus process. RESULTS A systematic review involving 81 studies and a scoping review of 17 guidelines and frameworks informed the initial standards and recommendations. Subsequently, 77 experts (including eight people with lived experience) across 33 countries (33% were low- to middle-resource countries) participated in the Delphi study and achieved ≥94.8% agreement for seven standards, (1) Person-Centered Care; (2) Coordinated and Integrated Care; (3) Evidence-Based and Comprehensive Care; (4) Evaluated and Communicated Care; (5) Accessible and Equitable Care; (6) Sustainable and Resourced Care; and (7) Research and Data-Driven Care, and ≥84.2% agreement across 45 practice recommendations. CONCLUSION Standards of survivorship care for people affected by advanced or metastatic cancer are provided. These MASCC-ASCO standards support optimization of health outcomes and care experiences by providing guidance to stakeholders (health care professionals, leaders, and administrators; governments and health ministries; policymakers; advocacy agencies; cancer survivors and caregivers). Practice recommendations may be used to facilitate future research, practice, policy, and advocacy efforts. Additional information is available at www.mascc.org , www.asco.org/standards and www.asco.org/survivorship-guidelines .
“You're in the Middle of the World”
Authors: Kumar Rebecca 
Published: April 2024

Abstract
Despite Barry Jenkins's pronounced and intentional allusions to the work of Hong Kong auteur Wong Kar Wai, film scholars have generally made little of the pervasive Asian elements in Moonlight (2016). This essay, however, offers a sustained study of the film's aesthetic and political engagement with Wong's cinema. It highlights how the distinct Asian femininity, or ornamentalism, of Days of Being Wild (1990) and In the Mood for Love (2001) are translated into Moonlight and reinforce the film's key themes on Black queerness, especially its ontological implications for Black (non)being and its material implications for Black embodiment. Furthermore, this essay claims that by borrowing from films in which Wong visually explores postcolonial loss—especially Happy Together (1997), about a pair of queer male Hong Kong migrants who work and live in Buenos Aires—Jenkins emphasizes the historic and global magnitude of queer Black diasporic dislocation and humanlessness. Ultimately, this essay outlines how the convergence of Black and Asian forms in Moonlight disrupts white, liberal, humanist scripts on racial, gendered, and sexual formation.
Reformulating Black Cinematic Labor
Authors: Baker Courtney R. 
Published: April 2024

AbstractConsidering the 2022 film Nope, this essay pushes beyond indexical and ontological readings of blackness in film in order to consider how invisible forms of blackness—in particular, the labor of black film workers—are inscribed in the film text. It argues that the inscription of black labor and a reading of film as an effect of labor supply a reformulation of a deracinated film formalism. Mining Nope's self-reflexive gestures, the essay explores the film's reformulation of American film history and its navigation of the invisible and the spectacular as the limited forms of manifesting blackness in cinema.
“If Today Never Gives Up In Me”
Authors: Chung Kelly I. 
Published: April 2024

Abstract
Featuring a conversation with the artist, this essay offers a reading of Amina Ross's aesthetic practice across a selection of their work. Alongside Fred Moten's own critique of the overrepresentation of blackness as death-driven, it highlights their ongoing contributions to what they refer to as “black work,” or aesthetic experimentations in making multiple forms of blackness appear and emerge in the present moment. For Ross, the present is not merely a death-driven end but, at once, a rigid structure and a “space of unlimited potential” wherein blackness and black life may be experienced in their multiplicity. Placing objects in unexpected positions and built structures, Ross seeks to widen spectators' sense of their own present and immediate environment. As such, the present is, for them, a space to be, not escaped from, but worked on and reenvisioned in an effort to make a black present possible, livable, and replenishable.
SARS-CoV-2 NSP5 antagonizes MHC II expression by subverting histone deacetylase 2
Authors: Taefehshokr Nima , Lac Alex , Vrieze Angela M. , Dickson Brandon H. , Guo Peter N. , Jung Catherine , Blythe Eoin N. , Fink Corby , Aktar Amena , Dikeakos Jimmy D. , Dekaban Gregory A. , Heit Bryan 
Published: April 2024

ABSTRACT
SARS-CoV-2 interferes with antigen presentation by downregulating major histocompatibility complex (MHC) II on antigen-presenting cells, but the mechanism mediating this process is unelucidated. Herein, analysis of protein and gene expression in human antigen-presenting cells reveals that MHC II is downregulated by the SARS-CoV-2 main protease, NSP5. This suppression of MHC II expression occurs via decreased expression of the MHC II regulatory protein CIITA. CIITA downregulation is independent of the proteolytic activity of NSP5, and rather, NSP5 delivers HDAC2 to the transcription factor IRF3 at an IRF-binding site within the CIITA promoter. Here, HDAC2 deacetylates and inactivates the CIITA promoter. This loss of CIITA expression prevents further expression of MHC II, with this suppression alleviated by ectopic expression of CIITA or knockdown of HDAC2. These results identify a mechanism by which SARS-CoV-2 limits MHC II expression, thereby delaying or weakening the subsequent adaptive immune response.
Assessing antibacterial efficacy of a polyhexanide hydrogel versus alginate-based wound dressing in burns
Authors: De Decker Ignace , Janssens Dries , De Mey Kimberly , Hoeksema Henk , Simaey Marie , De Coninck Petra , Verbelen Jozef , De Pessemier Alina , Blondeel Phillip , Monstrey Stan , Claes Karel EY 
Published: April 2024

Objective: Burn injuries pose a heightened risk of infection, which is primarily responsible for increased morbidity and mortality. Factors such as extensive skin damage and compromised immunity exacerbate this vulnerability. Pseudomonas aeruginosa and Staphylococcus aureus are frequently identified in burns, with Gram-negative Pseudomonas aeruginosa often resistant to antibacterial agents. While Flaminal, an alginate-based wound dressing (Flen Health, Belgium), aids wound healing, its antibacterial effects are limited compared with 1% silver sulfadiazine (1% SSD). In contrast, Prontosan Wound Gel X, a betaine and polyhexanide-based hydrogel (B. Braun Medical AG, Switzerland), has been shown to effectively combat various microbes and promotes wound healing. Method: In this study, two research cohorts were retrospectively established (control group: patients receiving standard of care with the alginate-based wound dressing; intervention group: patients receiving the polyhexanide hydrogel wound dressing), comprising patients admitted to a burn centre between 2019 and 2022. Patients were eligible when continuous wound treatment with either of the two wound dressings was performed. Laser Doppler imaging (LDI) scans were conducted. Regions of interest (ROIs) were selected based on LDI scans and divided into healing time categories. Wound swabs were collected and the presence of Pseudomonas aeruginosa and Staphylococcus aureus was documented. Bacterial load was evaluated using a semiquantitative scale. Wound healing was recorded. Results: The control group consisted of 31 patients with 93 ROIs, while the intervention group had 67 ROIs involving 29 patients. Both groups exhibited similar proportions of healing time categories (p>0.05). The polyhexanide hydrogel dressing outperformed the alginate-based dressing in antiseptic efficacy by significantly reducing the incidence of Pseudomonas aeruginosa- and Staphylococcus aureus-positive cultures in patients' wounds. Wound healing time for conservative treatment was comparable between groups. Conclusion: In this study, the polyhexanide hydrogel dressing minimised Pseudomonas aeruginosa and Staphylococcus aureus colonisation in burn wounds, demonstrating strong antibacterial properties, emphasising its potential to minimise infections in burn injuries.
Genetically predicted fatty liver disease and risk of psychiatric disorders: A mendelian randomization study
Authors: Xu Wei-Ming , Zhang Hai-Fu , Feng Yong-Hang , Li Shuo-Jun , Xie Bi-Yun 
Published: April 2024

BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ArLD) constitute the primary forms of chronic liver disease, and their incidence is progressively increasing with changes in lifestyle habits. Earlier studies have documented a correlation between the occurrence and development of prevalent mental disorders and fatty liver.
AIM
To investigate the correlation between fatty liver and mental disorders, thus necessitating the implementation of a mendelian randomization (MR) study to elucidate this association.
METHODS
Data on NAFLD and ArLD were retrieved from the genome-wide association studies catalog, while information on mental disorders, including Alzheimer's disease, schizophrenia, anxiety disorder, attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder, multiple personality disorder, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and schizophrenia was acquired from the psychiatric genomics consortium. A two-sample MR method was applied to investigate mediators in significant associations.
RESULTS
After excluding weak instrumental variables, a causal relationship was identified between fatty liver disease and the occurrence and development of some psychiatric disorders. Specifically, the findings indicated that ArLD was associated with a significantly elevated risk of developing ADHD (OR: 5.81, 95%CI: 5.59-6.03, P < 0.01), bipolar disorder (OR: 5.73, 95%CI: 5.42-6.05, P = 0.03), OCD (OR: 6.42, 95%CI: 5.60-7.36, P < 0.01), and PTSD (OR: 5.66, 95%CI: 5.33-6.01, P < 0.01). Meanwhile, NAFLD significantly increased the risk of developing bipolar disorder (OR: 55.08, 95%CI: 3.59-845.51, P < 0.01), OCD (OR: 61.50, 95%CI: 6.69-565.45, P < 0.01), and PTSD (OR: 52.09, 95%CI: 4.24-639.32, P < 0.01).
CONCLUSION
Associations were found between genetic predisposition to fatty liver disease and an increased risk of a broad range of psychiatric disorders, namely bipolar disorder, OCD, and PTSD, highlighting the significance of preventive measures against psychiatric disorders in patients with fatty liver disease.
Waist subcutaneous soft tissue metastasis of rectal mucinous adenocarcinoma: A case report
Authors: Gong Zi-Xing , Li Guo-Lei , Dong Wen-Min , Xu Zhao , Li Rui , Lv Wen-Xia , Yang Jing , Li Zhong-Xin , Xing Wei 
Published: April 2024

BACKGROUND
Rectal mucinous adenocarcinoma (MAC) is a rare pathological type of rectal cancer with unique pathological features and a poor prognosis. It is difficult to diagnose and treat early because of the lack of specific manifestations in some aspects of the disease. The common metastatic organs of rectal cancer are the liver and lung; however, rectal carcinoma with metastasis to subcutaneous soft tissue is a rare finding.
CASE SUMMARY
In this report, the clinical data, diagnosis and treatment process, and postoperative pathological features of a patient with left waist subcutaneous soft tissue masses were retrospectively analyzed. The patient underwent surgical treatment after admission and recovered well after surgery. The final pathological diagnosis was rectal MAC with left waist subcutaneous soft tissue metastasis.
CONCLUSION
Subcutaneous soft tissue metastasis of rectal MAC is rare, and it can suggest that the tumor is disseminated, and it can appear even earlier than the primary malignant tumor, which is occult and leads to a missed diagnosis and misdiagnosis clinically. When a subcutaneous soft tissue mass of unknown origin appears in a patient with rectal cancer, a malignant tumor should be considered.
Immediate secondary rhinoplasty using a folded dermofat graft for resolving complications related to silicone implants: A case report
Authors: Kim Hoon , Kim Jong Hyup , Koh In Chang , Lim Soo Yeon 
Published: April 2024

BACKGROUND
Various surgical techniques have been developed to enhance the nose shapes of Asian patients. Silicone implant augmentation rhinoplasty is widely used because it is relatively easy to perform and often yields satisfactory outcomes. However, this technique may lead to complications, including ischemia, necrosis, and over-augmentation. The most appropriate management of these complications, including infection, is immediate implant removal and revision surgery once the accompanying inflammation has healed. Occasionally, the patient may experience distress from nasal deformities during the intervention period.
CASE SUMMARY
Herein, we describe the case of a patient who underwent a secondary dorsal augmentation, with a folded dermofat graft harvested from the inguinal area and simultaneous implant removal, successfully preventing dimpling of the nasal deformity.
CONCLUSION
This surgical method can effectively manage implant-related complications following augmentation rhinoplasty using a silicone implant and provide satisfactory patient outcomes.
Sustained remission of Cronkhite-Canada syndrome after corticosteroid and mesalazine treatment: A case report
Authors: Chen Ya-Lan , Wang Rui-Yao , Mei Ling , Duan Ran 
Published: April 2024

BACKGROUND
Cronkhite-Canada syndrome (CCS) is a rare disease of unknown etiology. The optimal treatment for CCS remains unknown. Treatment with corticosteroids is considered the mainstay treatment because of its high efficacy, but the therapeutic strategy for steroid-resistant CCS is not yet established.
CASE SUMMARY
This is the case of an 81-year-old woman who was diagnosed with CCS. Given her severe diarrhea, nausea, vomiting, and hypoproteinemia, hormone therapy (40 mg/d) was administered, and the symptoms improved within 1 wk. After 3 mo, the patient had no obvious symptoms. The polyps were significantly reduced on review gastroscopy and colonoscopy, thus hormone reduction gradually began. The hormone level was maintained at 10 mg/d after 6 mo. Despite the age of the patient and the side effects of hormones, the patient had no obvious discomfort. However, hormone drugs were discontinued, and mesalazine was administered orally at 3 g/d. The patient's symptoms continued to improve after a follow-up of 5 years.
CONCLUSION
Corticosteroids and mesalazine are potential treatment options for CCS.
Detection of LAMA2 c.715C>G:p.R239G mutation in a newborn with raised creatine kinase: A case report
Authors: Yuan Jing , Yan Xiang-Ming 
Published: April 2024

BACKGROUND
We report a rare case of primary clinical presentation featuring elevated creatine kinase (CK) levels in a neonate, which is associated with the LAMA2 gene. In this case, a heterozygous mutation in exon5 of the LAMA2 gene, c.715C>G (resulting in a change of nucleotide number 715 in the coding region from cytosine to guanine), induced an amino acid alteration p.R239G (No. 239) in the patient, representing a missense mutation. This observation may be elucidated by the neonatal creatine monitoring mechanism, a phenomenon not previously reported.
CASE SUMMARY
We analysed the case of a neonate presenting solely with elevated CK levels who was eventually discharged after supportive treatment. The chief complaint was identification of increased CK levels for 15 d and higher CK values for 1 d. Admission occurred at 18 d of age, and despite prolonged treatment with creatine and vitamin C, the elevated CK levels showed limited improvement. Whole exome sequencing revealed the presence of a c.715C>G mutation in LAMA2 in the newborn, correlating with a clinical phenotype. However, the available information offers insufficient evidence for clinical pathogenicity.
CONCLUSION
Mutations in LAMA2 are associated with the clinical phenotype of increased neonatal CK levels, for which no specific treatment exists. Whole genome sequencing facilitates early diagnosis.
Roads to nowhere but the belt is Gucci: has China’s Belt and Road Initiative been successful so far and why?
Authors: Becker Philipp 
Published: April 2024

This article assesses the success of China’s Belt and Road Initiative (BRI) with respect to three objectives: strengthening China’s geopolitical stance, spurring geo-economic development in the Western regions and instilling a spatial fix to overaccumulation and thirdly, providing profit opportunities to troubled state-owned enterprises. I find that the BRI has only delivered on the third aspect, with even the BRI’s signature white elephant projects providing windfall incomes to the state-owned enterprises (SOEs) constructing and operating them.
My explanation of this phenomenon is two-fold. Firstly, I argue that tense, coercive competition (Crotty, 1993) has spurred Chinese SOEs to revert to rent-seeking activity in order to stay afloat and realise managers’ cadre ambitions. As the state-owned Asset Supervision and Administrative Council (SASAC) evaluates manager performance based largely on company performance, demanding numbers that cannot be achieved under coercive competition in an environment of overcapacity, managers reverted to guanxi practices and corruption to secure under-the-counter deals, relying on soft budgets and beneficial lending practices. Amid tightening domestic regulation and Xi’s anti-corruption campaign, these strategies are becoming less viable and sustainable to pursue at home. As managers’ incentive structure has not evolved, pressure to seek rents persists, pushing SOEs to pursue their strategies abroad via the BRI. Secondly, the export of the strategies to persist amid coercive competition is enabled by a fragmented institutional environment, allowing SOEs to abuse asymmetries in information and outmanoeuvre stringent evaluation of their proposed BRI projects by mobilising political support through networks.
Stigma experiences, effects and coping among individuals affected by Buruli ulcer and yaws in Ghana
Authors: Tuwor Ruth Dede , Mtuy Tara B. , Amoako Yaw Ampem , Owusu Lucy , Oppong Michael Ntiamoah , Agbanyo Abigail , Agbavor Bernadette , Marks Michael , Walker Stephen L. , Yeboah-Manu Dorothy , Pullan Rachel L. , Dapaah Jonathan Mensah , Phillips Richard Odame , Palmer Jennifer ,   for the SHARP collaboration
Published: April 2024

Background
Stigma related to skin neglected tropical diseases like Buruli ulcer (BU) and yaws has remained underexplored and existing studies are limited to individual diseases despite the WHO call for integration in disease management. Within two districts in central Ghana, we explored stigma associated with BU and yaws to understand overlaps and disease-specific nuances to help guide integrated interventions.

Methodology/Principal findings
In-depth interviews were conducted with 31 current or formerly affected individuals to assess the experiences, effects and coping strategies adopted to manage disease related stigma. Data were analysed along broad themes based on the sociological construct of macro and micro interaction and Goffman’s treatise on stigma.
Disapproving community labels fueled by misconceptions were noted among BU participants which contributed to macro stigma experiences, including exclusion, discrimination and avoidance. In contrast, a high level of social acceptance was reported among yaws participants although some micro-level stigma (anticipated, felt and self-stigma) were noted by individuals with both diseases. While younger participants experienced name-calling and use of derogatory words to address affected body parts, older participants and caregivers discussed the pain of public staring. Stigma experiences had negative consequences on psychosocial well-being, schooling, and social relations, particularly for BU affected people. Problem-focused strategies including confrontation, selective disclosure and concealment as well as emotion-focused strategies (religious coping and self-isolation) were noted.

Conclusions and significance
The types and levels of stigma varied for BU and yaws. Stigma experiences also differed for adults and children in this setting and these differences should be accounted for in integrated interventions for these skin NTDs. School health programs need to prioritize educating school teachers about skin NTDs and the negative impact of stigma on the wellbeing of children.
Shoulder specific exercise therapy is effective in reducing chronic shoulder pain: A network meta-analysis
Authors: Silveira Anelise , Lima Camila , Beaupre Lauren , Chepeha Judy , Jones Allyson 
Published: April 2024

Background
Exercise therapy (ET) is frequently an early treatment of choice when managing shoulder pain, yet evidence on its efficacy to expedite recovery is inconsistent. Moreover, the value of adding adjunct therapies (i.e. injections, manual therapy, electrotherapy) to ET is currently unclear. This study combined both direct and indirect evidence across studies on the effectiveness of ET with/without adjunct therapies compared to usual medical care for adults with chronic shoulder pain.

Methods and findings
Using a network meta-analysis, randomized control trials comparing ET along with adjunct therapies were identified in MEDLINE, Embase, CINAHL, Sportdiscus, CENTRAL, Conference Proceedings Citation Index-Science, clinicaltrials.gov, and association websites. Outcomes included pain, range of motion (ROM), and health-related quality of life (HRQL) measures in adult patients with chronic shoulder pain. Data analysis used a Frequentist hierarchical model. CINeMA tool assessed the confidence in the results and Cochrane Risk of Bias tool assessed quality of studies.
54 studies primarily from Europe (40.38%) included 3,893 participants who were followed up to 52 weeks. Shoulder-specific ET (Mean difference (MD) = -2.1; 95% confidence interval (CI) = -3.5 to -0.7) or in combination with electro-physical agents (MD = -2.5; 95% CI = -4.2 to -0.7), injections (MD = -2.4; 95% CI = -3.9 to—1.04) or manual therapy (MD = -2.3; 95% CI = -3.7 to -0.8) decreased pain compared to usual medical care. Trends with ROM and HRQL scores were seen; however, only Manual Therapy (MD = -12.7 and 95% CI = -24.4 to -1.0) achieved meaningfully important changes. Sensitivity analysis excluding studies with high risk of bias showed similar results, with exception of injections that did not reach significance (MD = -1.3; 95% CI = -4.3 to 1.7).

Conclusion(s)
Shoulder-specific ET provided pain relief up to 52 weeks. Adjunct therapies to shoulder-specific ET added little value in reducing pain. The quality of evidence varied between moderate and very low.