bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post‐modification of azo dyes using an α‐phenyl diazo ester for improving the colour fixation properties of polyurethane fibre
Authors: Jiang Hua , Shi Lulu , Xie Xiaokang , Wang Ye 
Published: June 2024

AbstractColour fastness of polyurethane fibre dyed with conventional disperse dyes is always poor owing to the insufficient affinity between fibres and dyes. Thus, three novel azo dyes containing an α‐phenyl diazo ester moiety were designed in this study. The dyes were synthesised through two‐step post‐modification of a hydroxylated azo benzene chromophore. All three dyes were characterised using proton and carbon nuclear magnetic resonance, high‐resolution mass spectrometry and infrared spectrometry. The ultraviolet‐visible absorption and thermal properties of the dyes were also studied. Fixation properties of these dyes on polyurethane fibre were examined using samples dyed using a non‐aqueous dyeing method. Practicality of these dyes, that is colour depth, fixation value, colour fastness and dye migration degree, was further verified on fibre dyed via an aqueous dyeing method. Finally, the mechanical properties of the dyed polyurethane fibre were explored.
Cardiac magnetic resonance in advanced heart failure
Authors: Coraducci Francesca , De Zan Giulia , Fedele Damiano , Costantini Pietro , Guaricci Andrea Igoren , Pavon Anna Giulia , Teske Arco , Cramer Maarten Jan , Broekhuizen Lysette , Van Osch Dirk , Danad Ibrahim , Velthuis Birgitta , Suchá Dominika , van der Bilt Ivo , Pizzi Carmine , Russo Antonio Dello , Oerlemans Marish I.F.J. , van Laake Linda W. , van der Harst Pim , Guglielmo Marco 
Published: June 2024

AbstractHeart failure (HF) is a chronic and progressive disease that often progresses to an advanced stage where conventional therapy is insufficient to relieve patients' symptoms. Despite the availability of advanced therapies such as mechanical circulatory support or heart transplantation, the complexity of defining advanced HF, which requires multiple parameters and multimodality assessment, often leads to delays in referral to dedicated specialists with the result of a worsening prognosis. In this review, we aim to explore the role of cardiac magnetic resonance (CMR) in advanced HF by showing how CMR is useful at every step in managing these patients: from diagnosis to prognostic stratification, hemodynamic evaluation, follow‐up and advanced therapies such as heart transplantation. The technical challenges of scanning advanced HF patients, which often require troubleshooting of intracardiac devices and dedicated scans, will be also discussed.
The framing of educational digitalization: A scoping review of empirical studies
Authors: Høydal Øyunn Syrstad , Finne Joakim , Malmberg‐Heimonen Ira 
Published: June 2024

AbstractThe aim of this scoping review is to systematically investigate the framing of European empirical research on digitalization for teaching and learning in the classroom within primary and secondary school (K‐12/K‐13). We believe it is crucial to gain insight in the framing of the knowledge production taking place in the fast‐evolving field of educational digitalization. The framing will influence the research results and conclusions published as well as potentially impact on how policy and practices of educational digitalization evolve. Our findings reveal that the studies of educational digitalization are spread relatively thin over a wide variety of academic journals and fields, where journals within the edtech field dominate in numbers. The dominant technological framing could indicate research driven by technological perspectives rather than pedagogical interests. The research is unevenly geographically distributed. There is a lack of European comparative studies as well as studies framing digitalization as something else than a tool for making learning more effective.
Steven A. Brown and the synchronization of circadian rhythms by body temperature cycles
Authors: Schibler Ueli 
Published: June 2024

AbstractThe mammalian circadian timing system has a hierarchical architecture, with a central pacemaker located in the brain's suprachiasmatic nucleus orchestrating rhythms in behaviour and physiology. In cooperation with environmental cycles, it synchronizes the phases of peripheral oscillators operating in most cells of the body. Even cells kept in tissue culture harbour self‐sustained and cell‐autonomous circadian clocks that keep ticking throughout their lifespan. The master pacemaker in the suprachiasmatic nucleus is synchronized primarily by light–dark cycles, whereas peripheral oscillators are phase entrained by a multitude of systemic signalling pathways. These include pathways depending on feeding–fasting cycles, cellular actin polymerization dynamics, endocrine rhythms and, surprisingly, body temperature oscillations. Using tissue culture and murine models, Steve Brown was the first one to demonstrate that shallow rhythms of mammalian body temperature are timing cues (zeitgebers) for peripheral circadian clocks.
Generalized hop‐based approaches for identifying influential nodes in social networks
Authors: Biswas Tarun Kumer , Abbasi Alireza , Chakrabortty Ripon Kumar 
Published: June 2024

AbstractLocating a set of influential users within a social network, known as the Influence Maximization (IM) problem, can have significant implications for boosting the spread of positive information/news and curbing the spread of negative elements such as misinformation and disease. However, the traditional simulation‐based spread computations under conventional diffusion models render existing algorithms inefficient in finding optimal solutions. In recent years, hop and path‐based approaches have gained popularity, particularly under the cascade models to address the scalability issue. Nevertheless, these existing functions vary based on the considered hop‐distance and provide no guidance on capturing spread sizes beyond two‐hops. In this paper, we introduce Hop‐based Expected Influence Maximization (HEIM), an approach utilizing generalized functions to compute influence spread across varying hop‐distances in conventional diffusion models. We extend our investigation to the Linear Threshold (LT) model, in addition to the Independent Cascade (IC) and Weighted Cascade (WC) models, filling a gap in current literature. Our theoretical analysis shows that the proposed functions preserve both monotonicity and submodularity, and the proposed HEIM algorithm can achieve an approximation ratio of under a limited hop‐measures, whereas a multiplicative ‐approximation under global measures. Furthermore, we show that expected spread methods can serve as a better benchmark approach than existing simulation‐based methods. The performance of the HEIM algorithm is evaluated through experiments on three real‐world networks, and is compared to six other existing algorithms. Results demonstrate that the three‐hop based HEIM algorithm achieves superior solution quality, ranking first in statistical tests, and is notably faster than existing benchmark approaches. Conversely, the one‐hop‐based HEIM offers faster computation while still delivering competitive solutions, providing decision‐makers with flexibility based on application needs.
The process in‐between: Parents' perceptions about how practitioners promote the outcomes of the Incredible Years Basic program
Authors: Leitão Sara M. , Francisco Rita , Seabra‐Santos Maria João , Gaspar Maria Filomena 
Published: June 2024

AbstractPractitioners are recognized as one of the key components that make parenting interventions meaningful and helpful to families, and the impact of practitioners' skills on the outcomes of parenting interventions has been consistently recognized in research. However, the mechanisms and ongoing processes through which the practitioners' actions and skills may impact parental engagement and other outcomes remain unknown. This qualitative study explored parents' perceptions about the processes through which specific practitioners' skills contribute to the outcomes of the Incredible Years Basic Parent Program (IYPP). Twenty‐four Portuguese parents who had completed the IYPP were interviewed in four focus groups, and the data were analyzed through thematic analysis. Practitioners' skills were perceived by parents as having an impact on their engagement in the program, their process of change, and their interpersonal relationships. Practitioners were perceived to demonstrate their influence in the intervention process through six different roles: the roles of a confidant, a positive coach, a partner, a maestro, a tailor, and a congruent person. This study reinforces the prominent role of practitioners in enabling parental outcomes of an evidence‐based parenting program and suggests that more attention should be paid to continuing supervision and other professional development processes.
The HMG‐box module in FACT is critical for suppressing epigenetic variegation of heterochromatin in fission yeast
Authors: Takahata Shinya , Taguchi Asahi , Takenaka Ayaka , Mori Miyuki , Chikashige Yuji , Tsutsumi Chihiro , Hiraoka Yasushi , Murakami Yota 
Published: June 2024

AbstractChromatin condensation state is the key for retrieving genetic information. High‐mobility group protein (HMG) proteins exhibit DNA‐binding and bending activities, playing an important role in the regulation of chromatin structure. We have shown that nucleosomes tightly packaged into heterochromatin undergo considerable dynamic histone H2A‐H2B maintenance via the direct interaction between HP1/Swi6 and facilitate chromatin transcription (FACT), which is composed of the Spt16/Pob3 heterodimer and Nhp6. In this study, we analyzed the role of Nhp6, an HMG box protein, in the FACT at heterochromatin. Pob3 mutant strains showed derepressed heterochromatin‐dependent gene silencing, whereas Nhp6 mutant strains did not show significant defects in chromatin regulation or gene expression, suggesting that these two modules play different roles in chromatin regulation. We expressed a protein fusing Nhp6 to the C‐terminus of Pob3, which mimics the multicellular FACT component Ssrp1. The chromatin‐binding activity of FACT increased with the number of Nhp6 fused to Pob3, and the heterochromatin formation rate was promoted more strongly. Furthermore, we demonstrated that this promotion of heterochromatinization inhibited the heterochromatic variegation caused by epe1+ disruption. Heterochromatic variegation can be observed in a variety of regulatory steps; however, when it is caused by fluctuations in chromatin arrangement, it can be eliminated through the strong recruitment of the FACT complex.
Managing careers of academics in higher education institutions: A moderated mediation model
Authors: Kozhakhmet Sanat , Moldashev Kairat 
Published: June 2024

AbstractThis research examines the role of input and process‐based approaches in enhancing faculty members' commitment to their research careers in the context of higher education. Specifically, we investigate the mediating effect of research self‐efficacy on the relationship between professional research network and commitment to research career, as well as the moderating effect of career aspiration. Our findings reveal a direct positive link between professional research network and commitment to research career. Moreover, research self‐efficacy is found to mediate the relationship between professional research network and commitment to research career. We also find that career aspiration did not moderate the relationship between research self‐efficacy and commitment to research career. Our study contributes to the literature by providing a more comprehensive understanding of how professional research networks may enhance research self‐efficacy, leading to greater commitment to research careers among faculty members in higher education institutions. Additionally, our research sheds light on the important role of career aspiration as a key factor in shaping the relationship between research self‐efficacy and commitment to research career.
Frenemies: Exploring interfirm credit between an incumbent and a capital‐constrained startup
Authors: Chamnisampan Netnapha , Wu Cheng‐Han 
Published: June 2024

AbstractInterfirm credit, a financial relationship between two firms, has garnered recent attention due to its potential to aid innovative startups' funding challenges and shape competitive dynamics. We examine a supply chain consisting of an incumbent and a capital‐constrained startup firm. The startup's entry may cannibalize the incumbent's market share. Therefore, we model their interaction as a Stackelberg game, with the incumbent leading. The startup faces funding challenges and can opt for bank financing, interfirm credit, or mixed financing. Under interfirm credit, the incumbent and startup firms engage in financial collaboration, which requires the incumbent to decide on the trade‐off between profit sharing and market erosion. We consider two cases of financial sufficiency: (i) sufficient funds for production that satisfy the loan amount required for the startup firm's production and (ii) limited funds for production that are insufficient for the startup firm's needs and limit the startup firm's production. We find that bank financing is not always beneficial to firms. Specifically, under limited funds for production, when a startup has moderate initial available funds, he will opt for profit sharing with the incumbent and prefer interfirm credit, allowing both firms to achieve a win‐win outcome. However, suppose the incumbent strategically determines the interest rate. In that case, mixed financing becomes advantageous for both firms when the startup firm's initial available funds are high and the loan amount is ample. Finally, when the startup predetermines the loan amount, he will pursue economic funding if his product is competitive.
Comprehensive analysis of same day discharge after atrial fibrillation ablation: Clinical, cost, and patient reported outcomes
Authors: Zenger Brian , Torre Michael , Zhang Yue , Boo Leeming , Jamshidian Farid , Young Jeff , Bunch Thomas J. , Steinberg Benjamin A. 
Published: June 2024

AbstractBackgroundSame day discharge (SDD) following atrial fibrillation (AF) ablation procedure has emerged as routine practice, and primarily driven by operator discretion. However, the impacts of SDD on clinical outcomes, healthcare system costs, and patient reported outcomes (PROs) have not been systematically studied.MethodsWe retrospectively analyzed patients undergoing routine AF ablation procedures with SDD versus overnight observation (NSDD). After propensity adjustment we compared postprocedure adverse events (AEs), healthcare system costs, and changes in PROs.ResultsWe identified 310 cases, with 159 undergoing SDD and 151 staying at least one midnight in the hospital (NSDD). Compared with NSDD, SDD patients were similar age (mean 64 vs. 66, p = 0.3), sex (26% female vs. 27%, p = 0.8), and with lower mean CHADS2‐VA2Sc scores (2.0 vs. 2.7; p < 0.011). The primary outcome of AEs was noninferior in SDD versus NSDD patients (odds ratio 0.45, 95% confidence interval 0.21−0.99; noninferiority margin of 10%). There were also no differences in overall cost to the healthcare system between SDD and NSDD (p = 0.11). PROs numerically favored SDD (p = NS for all scores).ConclusionsPhysician selection for SDD appears at least as safe as NSDD with respect to clinical outcomes and SDD is not significantly less costly to the health system. There is a trend towards more favorable, general PROs among SDD patients. Routine SDD should be strongly considered for patients undergoing routine AF ablation procedures.
Psychosocial burden of autoimmune blistering diseases: A comprehensive survey study
Authors: White Marney A. , Hoffman Victoria M. , Yale Marc , Strong Rebecca , Tomayko Mary M. 
Published: June 2024

AbstractBackgroundAutoimmune blistering diseases (AIBDs) are severe dermatologic disorders known for their debilitating physical impact. Recent research has reported that AIBDs lead to psychosocial impairment, including depression and anxiety. Missing from the extant literature is an examination of the impact of AIBDs on body image and related psychological constructs.ObjectivesThe current study seeks to characterize the psychological and social consequences of AIBD diagnosis, with particular attention to body image dissatisfaction.MethodsWe conducted a survey study of adults with AIBDs. The survey was open from February 2023 to March 2023. Validated self‐report questionnaires assessed depressive symptomatology, body image disturbance and quality of life. Demographic information and self‐reported psychiatric history before and after AIBD diagnosis were collected via self‐report. Participants were 451 adults with AIBDs, recruited through the International Pemphigus and Pemphigoid Foundation newsletters, email distribution lists and social media.ResultsParticipants reported increased incidence of psychiatric disorders following AIBD diagnosis. Participants reported high levels of depressive symptomatology and impairments to quality of life compared to other patient groups. The sample reported extremely high levels of body image disturbance, more so than other patients with disfiguring diseases or injury. Correlation analyses revealed significant relationships between body image variables and quality of life, even after controlling for depression.ConclusionsCurrent treatment guidelines for AIBDs focus primarily on the management of disease flares and the consequences of immunosuppression, without consideration of the psychosocial consequences of the disease. The current study underscores the need for mental health support for patients with AIBDs.
Validation of a new acoustic telemetry transmitter for the study of predation events in small fishes
Authors: Shorgan Mitchell B. , Reid Heather Bauer , Ivanova Silviya V. , Fisk Aaron T. , Cooke Steven J. , Raby Graham D. 
Published: June 2024

AbstractAcoustic telemetry has emerged as an important tool for studying the movement and behavior of aquatic animals. Predation‐sensing acoustic transmitters combine the functions of typical acoustic transmitters with the added ability to identify the predation of tagged animals. The objective of this paper was to assess the performance of a newly miniaturized acid‐based predation‐sensing acoustic transmitter (Innovasea V3D; 0.33 g in air). We conducted staged predation events in the laboratory where acoustically tagged rainbow trout (Oncorhynchus mykiss) were fed to largemouth bass (Micropterus nigricans) at 3.3–7.0, 9.0–10.8, 16.0–20.0, and 22.0–25.8°C. We also conducted false‐positive tests where tagged rainbow trout were held at 10.0 and 16.8°C without the risk of predation. Predation events were successfully identified in 92% of the staged predation trials. Signal lag (i.e., the time required for a predation tag to indicate that predation occurred) ranged from 0.11 to 6.29 days and decreased strongly with increasing water temperature and increased with increasing body mass of the tagged prey. Tag retention in the gut of the predator was much more variable than signal lag and was influenced by water temperature and individual predators but not by prey mass. No false positives were detected after 60 days at either temperature (n = 27 individuals). Although the relationships between water temperature, signal lag, and retention time are likely species‐specific, the data reported here provide useful information for the use of these transmitters to study predation in wild fishes, especially for temperate, freshwater fish.
FoxO1 silencing in Atp7b−/− neural stem cells attenuates high copper‐induced apoptosis via regulation of autophagy
Authors: Zhang Yu , Wang Meixia , Tang Lulu , Yang Wenming , Zhang Jing 
Published: June 2024

AbstractWilson disease (WD) is a severely autosomal genetic disorder triggered by dysregulated copper metabolism. Autophagy and apoptosis share common modulators that process cellular death. Emerging evidences suggest that Forkhead Box O1 over‐expression (FoxO1‐OE) aggravates abnormal autophagy and apoptosis to induce neuronal injury. However, the underlying mechanisms remain undetermined. Herein, the aim of this study was to investigate how regulating FoxO1 affects cellular autophagy and apoptosis to attenuate neuronal injury in a well‐established WD cell model, the high concentration copper sulfate (CuSO4, HC)‐triggered Atp7b−/− (Knockout, KO) neural stem cell (NSC) lines. The FoxO1‐OE plasmid, or siRNA‐FoxO1 (siFoxO1) plasmid, or empty vector plasmid was stably transfected with recombinant lentiviral vectors into HC‐induced Atp7b−/− NSCs. Toxic effects of excess deposited copper on wild‐type (WT), Atp7b−/− WD mouse hippocampal NSCs were tested by Cell Counting Kit‐8 (CCK‐8). Subsequently, the FoxO1 expression was evaluated by immunofluorescence (IF) assay, western blot (WB) and quantitative real‐time polymerase chain reaction (qRT‐PCR) analysis. Meanwhile, the cell autophagy and apoptosis were evaluated by flow cytometry (FC), TUNEL staining, 2,7‐dichlorofluorescein diacetate (DCFH‐DA), JC‐1, WB, and qRT‐PCR. The current study demonstrated a strong rise in FoxO1 levels in HC‐treated Atp7b−/− NSCs, accompanied with dysregulated autophagy and hyperactive apoptosis. Also, it was observed that cell viability was significantly decreased with the over‐expressed FoxO1 in HC‐treated Atp7b−/− WD model. As intended, silencing FoxO1 effectively inhibited abnormal autophagy in HC‐treated Atp7b−/− NSCs, as depicted by a decline in LC3II/I, Beclin‐1, ATG3, ATG7, ATG13, and ATG16, whereas simultaneously increasing P62. In addition, silencing FoxO1 suppressed apoptosis via diminishing oxidative stress (OS), and mitochondrial dysfunction in HC‐induced Atp7b−/− NSCs. Collectively, these results clearly demonstrate the silencing FoxO1 has the neuroprotective role of suppressing aberrant cellular autophagy and apoptosis, which efficiently attenuates neuronal injury in WD.image
Applying machine learning to construct an association model for lung cancer and environmental hormone high‐risk factors and nursing assessment reconstruction
Authors: Lee Pin‐Chieh , Lin Mong‐Wei , Liao Hsien‐Chi , Lin Chan‐Yi , Liao Pei‐Hung 
Published: June 2024

AbstractIntroductionTo utilize machine learning techniques to develop an association model linking lung cancer and environmental hormones to enhance the understanding of potential lung cancer risk factors and refine current nursing assessments for lung cancer.DesignThis study is exploratory in nature. In Stage 1, data were sourced from a biological database, and machine learning methods, including logistic regression and neural‐like networks, were employed to construct an association model. Results indicate significant associations between lung cancer and blood cadmium, urine cadmium, urine cadmium/creatinine, and di(2‐ethylhexyl) phthalate. In Stage 2, 128 lung adenocarcinoma patients were recruited through convenience sampling, and the model was validated using a questionnaire assessing daily living habits and exposure to environmental hormones.ResultsAnalysis reveals correlations between the living habits of patients with lung adenocarcinoma and exposure to blood cadmium, urine cadmium, urine cadmium/creatinine, polyaromatic hydrocarbons, diethyl phthalate, and di(2‐ethylhexyl) phthalate.ConclusionsAccording to the World Health Organization's global statistics, lung cancer claims approximately 1.8 million lives annually, with more than 50% of patients having no history of smoking or non‐traditional risk factors. Environmental hormones have garnered significant attention in recent years in pathogen exploration. However, current nursing assessments for lung cancer risk have not incorporated environmental hormone‐related factors. This study proposes reconstructing existing lung cancer nursing assessments with a comprehensive evaluation of lung cancer risks.Clinical RelevanceThe findings underscore the importance of future studies advocating for public screening of environmental hormone toxins to increase the sample size and validate the model externally. The developed association model lays the groundwork for advancing cancer risk nursing assessments.