bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of couple education and counseling on uptake of cervical cancer screening among women in Southern Ethiopia: a cluster randomized trial
Authors: Ayanto Samuel Yohannes , Belachew Tefera , Wordofa Muluemebet Abera 
Published: May 2024

Abstract
Cervical cancer is a major public health problem worldwide. Women die of the disease due to low early screening practices and its detection at advanced stages particularly in developing countries. Therefore, this study aimed to determine the effectiveness of couple education and counseling on the uptake of cervical screening among women. The study employed random allocation of 16 clusters into two study arms. A total of 288 women participated in the study. Structured home-based education and counseling were provided to the intervention group, while the control group received standard of care. Surveys were completed at baseline and end line. This study demonstrated that the proportion of women who had been aware of cervical cancer and screening grew from 22.9 to 100%, participants’ mean knowledge scores showed improvement from 3.18 to 11.99, and cervical screening uptake increased from 2.1% to 72.5% in the intervention group (p < 0.001). Also, the difference in differences of screening uptake between the study groups was statistically significant (p = 0.021).The study shows the effectiveness of the intervention package in improving the uptake of cervical screening in the study setting. Therefore, we recommend that creating awareness, increasing knowledge, and improving women’s perceptions through structured home-based couple education and counseling is important to improve cervical screening uptake among the target women.
Proteomic analysis of pleomorphic dermal sarcoma reveals a fibroblastic cell of origin and distinct immune evasion mechanisms
Authors: Klein Sebastian , Tolkach Yuri , Reinhardt Hans Christian , Buettner Reinhard , Quaas Alexander , Helbig Doris 
Published: May 2024

AbstractPleomorphic dermal sarcomas are infrequent neoplastic skin tumors, manifesting in regions of the skin exposed to ultraviolet radiation. Diagnosing the entity can be challenging and therapeutic options are limited. We analyzed 20 samples of normal healthy skin tissue (SNT), 27 malignant melanomas (MM), 20 cutaneous squamous cell carcinomas (cSCC), and 24 pleomorphic dermal sarcomas (PDS) using mass spectrometry. We explored a potential cell of origin in PDS and validated our findings using publicly available single-cell sequencing data. By correlating tumor purity (TP), inferred by both RNA- and DNA-sequencing, to protein abundance, we found that fibroblasts shared most of the proteins correlating to TP. This observation could also be made using publicly available SNT single cell sequencing data. Moreover, we studied relevant pathways of receptor/ligand (R/L) interactions. Analysis of R/L interactions revealed distinct pathways in cSCC, MM and PDS, with a prominent role of PDGFRB-PDGFD R/L interactions and upregulation of PI3K/AKT signaling pathway. By studying differentially expressed proteins between cSCC and PDS, markers such as MAP1B could differentiate between these two entities. To this end, we studied proteins associated with immunosuppression in PDS, uncovering that immunologically cold PDS cases shared a “negative regulation of interferon-gamma signaling” according to overrepresentation analysis.
Unveiling the dynamic and thermodynamic interactions of hydrocortisone with β-cyclodextrin and its methylated derivatives through insights from molecular dynamics simulations
Authors: Gholami Roya , Azizi Khaled , Ganjali Koli Mokhtar 
Published: May 2024

AbstractCyclodextrins (CDs) can enhance the stability and bioavailability of pharmaceutical compounds by encapsulating them within their cavities. This study utilized molecular dynamics simulations to investigate the interaction mechanisms between hydrocortisone (HC) and various methylated CD derivatives. The results reveal that the loading of HC into CD cavities follows different mechanisms depending on the degree and position of methylation. Loading into βCD and 6-MeβCD was more complete, with the hydroxyl groups of HC facing the primary hydroxyl rim (PHR) and the ketone side facing the secondary hydroxyl rim (SHR). In contrast, 2,3-D-MeβCD and 2,6-D-MeβCD showed a different loading mechanism, with the ketone side facing the PHR and the hydroxyl groups facing the SHR. The root mean square fluctuation (RMSF) analysis demonstrated that methylation increases the flexibility of CD heavy atoms, with 3-MeβCD and 2,3-D-MeβCD exhibiting the highest flexibility. However, upon inclusion of HC, 3-MeβCD, 2,3-D-MeβCD, 2-MeβCD, and 6-MeβCD showed a significant reduction in flexibility, suggesting a more rigid structure that effectively retains HC within their cavities. The radial distribution function revealed a significant reduction in the number of water molecules within the innermost layer of the methylated CD cavities, particularly in TMeβCD, indicating a decrease in polarity. The presence of HC led to the release of high-energy water molecules, creating more favorable conditions for HC loading. Conformational analysis showed that methylation caused a partial decrease in the area of the PHR, a significant decrease in the area of the middle rim, and a notable decrease in the area of the SHR. The loading of HC increased the area of the PHR in most derivatives, with the most pronounced increase observed in 2,6-D-MeβCD and 6-MeβCD. The analysis of interaction energies and binding free energies demonstrated that the binding of HC to methylated CD derivatives is thermodynamically more favorable than to βCD, with the strongest association observed for 6-MeβCD, 2-MeβCD, and 2,3-D-MeβCD.
An interpretable online prediction method for remaining useful life of lithium-ion batteries
Authors: Li Zuxin , Shen Shengyu , Ye Yifu , Cai Zhiduan , Zhen Aigang 
Published: May 2024

AbstractAccurate prediction of the remaining useful life (RUL) of lithium-ion batteries is advantageous for maintaining the stability of electrical systems. In this paper, an interpretable online method which can reflect capacity regeneration is proposed to accurately estimate the RUL. Firstly, four health indicators (HIs) are extracted from the charging and discharging process for online prediction. Then, the HIs model is trained using support vector regression to obtain future features. And the capacity model of Gaussian process regression (GPR) is trained and analyzed by Shapley additive explanation (SHAP). Meanwhile, the state space for capacity prediction is constructed with the addition of Gaussian non-white noise to simulate the capacity regeneration. And the modified predicted HIs and noise are obtained by unscented Kalman filter. Finally, according to SHAP explainer, the predicted HIs acting as the baseline and the modified HIs containing information on capacity regeneration are chosen to predict RUL. In addition, the bounds of confidence intervals (CIs) are calculated separately to reflect the regenerated capacity. The experimental results demonstrate that the proposed online method can achieve high accuracy and effectively capture the capacity regeneration. The absolute error of failure RUL is below 5 and the minimum confidence interval is only 2.
Association between voriconazole-induced visual hallucination and dopamine in an analysis of the food and drug administration (FDA) adverse event reporting system database
Authors: Kato Hideo , Shiraishi Chihiro , Hagihara Mao , Mikamo Hiroshige , Iwamoto Takuya 
Published: May 2024

AbstractVoriconazole is a second-generation azole used to treat serious fungal infections. Visual hallucinations constitute a representative adverse event caused by voriconazole. However, its mechanism of action remains unclear. In patients with schizophrenia or Parkinson’s disease, the frequency of visual hallucinations is associated with brain dopamine levels. This study investigated the frequency of visual hallucinations in patients treated with voriconazole alone or in combination with dopaminergic medicines or dopamine antagonists, using data collected from the Food and Drug Administration Adverse event Reporting System (FAERS). The frequency of visual hallucinations with voriconazole alone and in combination with a dopaminergic medicine (levodopa) or dopamine antagonists (risperidone and chlorpromazine) was compared using data from the FAERS between 2004 and 2023, using the reporting odds ratio (ROR) with relevant 95% confidence intervals (CI). The reference group comprised patients who had been administered voriconazole without dopaminergic medication or dopamine antagonists. Of the patients, 22,839, 90,810, 109,757, 6,435, 20, 83, and 26, respectively were treated with voriconazole, levodopa, risperidone, chlorpromazine, voriconazole plus levodopa, voriconazole plus risperidone, and voriconazole plus chlorpromazine. The occurrence of visual hallucinations increased when used in combination with levodopa (ROR = 12.302, 95% CI = 3.587–42.183). No increase in incidence was associated with the concomitant use of dopamine antagonists (risperidone, ROR = 1.721, 95% CI = 0.421–7.030; chlorpromazine, ROR = none, 95% CI = none). Dopaminergic medicine may increase the risk of visual hallucinations in patients treated with voriconazole. Whether voriconazole positively modulates dopamine production warrants further investigation using a translational research approach.
Role of CSF1R 550th-tryptophan in kusunokinin and CSF1R inhibitor binding and ligand-induced structural effect
Authors: Chompunud Na Ayudhya Chompunud , Graidist Potchanapond , Tipmanee Varomyalin 
Published: May 2024

AbstractBinding affinity is an important factor in drug design to improve drug-target selectivity and specificity. In this study, in silico techniques based on molecular docking followed by molecular dynamics (MD) simulations were utilized to identify the key residue(s) for CSF1R binding affinity among 14 pan-tyrosine kinase inhibitors and 15 CSF1R-specific inhibitors. We found tryptophan at position 550 (W550) on the CSF1R binding site interacted with the inhibitors' aromatic ring in a π–π way that made the ligands better at binding. Upon W550-Alanine substitution (W550A), the binding affinity of trans-(−)-kusunokinin and imatinib to CSF1R was significantly decreased. However, in terms of structural features, W550 did not significantly affect overall CSF1R structure, but provided destabilizing effect upon mutation. The W550A also did not either cause ligand to change its binding site or conformational changes due to ligand binding. As a result of our findings, the π–π interaction with W550's aromatic ring could be still the choice for increasing binding affinity to CSF1R. Nevertheless, our study showed that the increasing binding to W550 of the design ligand may not ensure CSF1R specificity and inhibition since W550-ligand bound state did not induce significantly conformational change into inactive state.
Photon Induced Scintillation Amplifier — The PISA concept
Authors: Monteiro C.M.B. , Mano R.D.P. , Roque R.J.C. , Neves J.P.G. 
Published: May 2024

Abstract
Photoelectron signal amplification in gas photomultipliers (GPMs) is achieved through
charge avalanche development in the holes of a cascade of hole-type microperforated foils. When a
voltage difference is applied between the metal film electrodes that are deposited on both
surfaces of those foils, an electric field with a high intensity is established inside the
holes. As a consequence, each electron entering those holes produces an electron avalanche that
emerges from the other side of the holes. A cascade of few foils is necessary for a single primary
electron to produce a final avalanche intense enough to be read out, in the anode electrode, above
the electronic noise. We propose the Photon Induced Scintillation Amplifier (PISA), where the
photoelectron signal amplification is obtained by reading out the photon scintillation produced in
the charge avalanches of solely one Micro-Hole-and-Strip-Plate-type microstructure with SiPMs. The
optical readout has the advantage of having the extra gain from the photosensor and is less
sensitive to electronic noise. A large photosensor gain produces large output signals that can
travel over long distances without significant degradation. This allows for the readout
electronics to be placed away from the photosensor and, thus, from the detector sensitive
volume. The scintillation readout plane can be made of a 2D-array of SiPMs, with size and pitch in
accordance with the needed scintillation level and position resolution. A first basic prototype
was assembled to present a proof-of-principle of the PISA concept.
Evaluating the contribution of methanotrophy kinetics to uncertainty in the soil methane sink
Authors: Dion-Kirschner Hannah , Nguyen Newton H , Frankenberg Christian , Fischer Woodward W 
Published: May 2024

Abstract
The oxidation of atmospheric methane by soil microbes is an important natural sink for a potent greenhouse gas. However, estimates of the current and future soil methane sink are highly uncertain. Here we assessed the extent to which methanotrophy enzyme kinetics contribute to uncertainty in projections of the soil methane sink. We generated a comprehensive compilation of methanotrophy kinetic data from modern environments and assessed the patterns in kinetic parameters present in natural samples. Our compiled data enabled us to quantify the global soil methane sink through two idealized calculations comparing first-order and Michaelis–Menten models of kinetics. We show that these two kinetic models diverge only under high atmospheric CH4 scenarios, where first-order rate constants slightly overestimate the soil methane sink size, but produce similar predictions at modern atmospheric concentrations. Our compilation also shows that the kinetics of methanotrophy in natural soil samples is highly variable—both the V
max (oxidation rate at saturation) and KM
(half-saturation constant) in natural samples span over six orders of magnitude. However, accounting for the correlation we observe between V
max and KM
reduces the range of calculated uptake rates by as much as 96%. Additionally, our results indicate that variation in enzyme kinetics introduces a similar magnitude of variation in the calculated soil methane sink as temperature sensitivity. Systematic sampling of methanotroph kinetic parameters at multiple spatial scales should therefore be a key objective for closing the budget on the global soil methane sink.
Biochar as a carbon dioxide removal strategy in integrated long-run mitigation scenarios
Authors: Bergero Candelaria , Wise Marshall , Lamers Patrick , Wang Yong , Weber Maridee 
Published: May 2024

Abstract
Limiting global warming to under 2 °C would require stringent mitigation and likely additional carbon dioxide removal (CDR) to compensate for otherwise unabated emissions. Because of its technology readiness, relatively low cost, and potential co-benefits, the application of biochar to soils could be an effective CDR strategy. We use the Global Change Analysis Model, a global multisector model, to analyze biochar deployment in the context of energy system uses of biomass with CDR under different carbon price trajectories. We find that biochar can create an annual sink of up to 2.8 GtCO2 per year, reducing global mean temperature increases by an additional 0.5%–1.8% across scenarios by 2100 for a given carbon price path. In our scenarios, biochar’s deployment is dependent on potential crop yield gains and application rates, and the competition for resources with other CDR measures. We find that biochar can serve as a competitive CDR strategy, especially at lower carbon prices when bioenergy with carbon capture and storage is not yet economical.
A review on plasma-based CO2 utilization: process considerations in the development of sustainable chemical production
Authors: LI Sirui , FELICE Giulia De , EICHKORN Simona , SHAO Tao , GALLUCCI Fausto 
Published: May 2024

Abstract
Plasma-based processes, particularly in carbon capture and utilization, hold great potential for addressing environmental challenges and advancing a circular carbon economy. While significant progress has been made in understanding plasma-induced reactions, plasma-catalyst interactions, and reactor development to enhance energy efficiency and conversion, there remains a notable gap in research concerning overall process development. This review emphasizes the critical need for considerations at the process level, including integration and intensification, to facilitate the industrialization of plasma technology for chemical production. Discussions centered on the development of plasma-based processes are made with a primary focus on CO2 conversion, offering insights to guide future work for the transition of the technology from laboratory scale to industrial applications. Identification of current research gaps, especially in upscaling and integrating plasma reactors with other process units, is the key to addressing critical issues. The review further delves into relevant research in process evaluation and assessment, providing methodological insights and highlighting key factors for comprehensive economic and sustainability analyses. Additionally, recent advancements in novel plasma systems are reviewed, presenting unique advantages and innovative concepts that could reshape the future of process development. This review provides essential information for navigating the path forward, ensuring a comprehensive understanding of challenges and opportunities in the development of plasma-based CCU process.
‘For the Benefit of the Afflicted’
Authors: L. Knoppers Laura 
Published: May 2024

Abstract
This chapter offers new insight into Puritan emotions and lived doctrine by focusing on the largely overlooked language of comfort that permeates Mary Rowlandson’s captivity narrative, The Sovereignty and Goodness of God (1682). Rowlandson’s harrowing account of her eleven-week captivity with the Algonquian peoples in wartime New England incorporates scripture verses, both remembered and read, that promise comfort. Yet the narrative tensions between rhetoric and traumatic experience, biblical citation and eye-witness accounting, providence and self-survival, along with the lack of closure after Rowlandson has been ransomed, have been seen as doctrinal failure and a turn towards the secular. Resituating Rowlandson in transatlantic Puritanism, we can see that the biblical language of comfort is inherently dual, pointing towards heavenly comfort that unsettles rather than valorizes the earthly. As such, the captivity narrative interacts closely with the sermon, the spiritual autobiography, and conversion narrative, showing how Rowlandson comes to understand her place as a pilgrim in this world.
Richard Baxter’s ‘Life’
Authors: Charlton Tom 
Published: May 2024

Abstract
This chapter explores how the nonconformist divine Richard Baxter chose to narrativize his experience as a Puritan during the civil wars, Interregnum, and the Restoration. It builds on the textual scholarship of the recent Oxford University Press edition of the Reliquiæ Baxterianæ to show how Baxter, and his posthumous editor Matthew Sylvester, revised and edited his principal autobiographical manuscript to present Baxter as the epitome of moderate Puritanism. Through his insistence that he was a moderate, Baxter’s self-conscious utilization of contemporary understandings of Puritanism for rhetorical and polemical effect both exploited and created shared textual habits in the representation of the Puritan experience to place himself at the centre of an evolving tradition. Baxter and ‘Puritanism’ became mutually reinforcing classifications; this chapter reveals the care and deliberation undertaken by Baxter and his editors to enable the definition of the former to buttress the latter and vice versa.
Conclusion
Authors: Constantine Mary-Ann 
Published: May 2024

Abstract
The conclusion returns the reader to Llanberis Lakes, and draws again on the work of Catherine Hutton to reflect on the reiterative nature of tour writing and its value as literature and as historical witness. It argues that because the form is so responsive to the immediate stimulus of the local and the specific, topographical writing is peculiarly resistant to linear narrative and argument: by being continually interrupted, its perspectives and chronologies perpetually shift. Tours thus reflect the messiness of history as it is always lived—contingent, accidental, and experienced at both micro and macro scales. The conclusion reasserts the importance of such texts in mapping the beginnings of our own unprecedented era of environmental degradation.
Pleistocene climate oscillations have shaped the expansion and contraction speciation model of the globose Eriosyce sect. Neoporteria cacti in Central Chile
Authors: Meriño Beatriz M , Villalobos-Barrantes Heidy M , Guerrero Pablo C 
Published: May 2024

Abstract

Background and Aims
Pleistocene climatic oscillations, characterized by arid (interglacial) and pluvial (glacial) phases, have profoundly impacted the floras of Mediterranean climates. Our study investigates the hypothesis that these climatic extremes have promoted phases of range expansion and contraction in the Eriosyce sect. Neoporteria, resulting in pronounced genetic structuring and restricted gene flow.

Methods
Using nuclear microsatellite markers, we genotyped 251 individuals across 18 populations, encompassing all 14 species and one subspecies within the Eriosyce sect. Neoporteria. Additionally, species distribution models were used to reconstruct past (Last Interglacial, Last Glacial Maximum and Mid-Holocene) and current potential distribution patterns, aiming to delineate the climatic influences on species range dynamics.

Key Results
The gene flow analysis disclosed disparate levels of genetic interchange among species, with marked restrictions observed between entities that are geographically or ecologically separated. Notably, Eriosyce subgibbosa from Hualpen emerged as genetically distinct, warranting its exclusion for clearer genetic clustering into north, central and south clusters. The species distribution models corroborated these findings, showing marked range expansions during warmer periods and contractions during colder times, indicating significant shifts in distribution patterns in response to climatic changes.

Conclusions
Our findings emphasize the critical role of Pleistocene climatic fluctuations in driving the dynamic patterns of range expansions and contractions that have led to geographical isolation and speciation within the Eriosyce sect. Neoporteria. Even in the face of ongoing gene flow, these climate-driven processes have played a pivotal role in sculpting the genetic architecture and diversity of species. This study elucidates the complex interplay between climatic variability and evolutionary dynamics among mediterranean cacti in central Chile, highlighting the necessity of considering historical climatic millennial oscillations in conservation and evolutionary biology studies.