bluuebunny/crossref_metadata_2025_split huggingface dataset:
Behaviour of multipotent maxillary bone‐derived cells on β‐tricalcium phosphate and highly porous bovine bone mineral
Authors: Payer Michael , Lohberger Birgit , Stadelmeyer Elke , Bartmann Christina , Windhager Reinhard , Jakse Norbert 
Published: April 2010

AbstractObjectives: The aim of this study was to test the applicability of multipotent maxillary cells (MMC) for cell therapy concepts and to evaluate their in vitro behaviour on two different bone substitutes.Material and methods: Cells isolated from maxillary bone from 10 donors were expanded using media containing human platelet lysate (HPL) replacing foetal bovine serum and differentiated towards both the osteogenic and the adipogenic lineage. Surface markers were determined by fluorescence‐activated cell sorting analysis. Calcium deposits, alkaline phosphatase (ALP) and osteocalcin (OC) were used as biomarkers of osteogenic differentiation. Oil Red O was used to verify adipogenic differentiation.The osteogenic lineage and undifferentiated controls were further cultured on natural bone mineral of bovine origin (BioOss®) and β‐tricalcium phosphate (Vitoss®) scaffolds. Scaffold efficacy and cell migration were evaluated with live cell imaging.Results: Isolated cells presented characteristics of bone marrow (BM)‐stromal cells and could easily be expanded to clinical scales. Cells expressed osteogenic and adipogenic markers when cultured with inductive media. There were no obvious differences in cell migration and growth behaviour between the two bone substitutes, but significantly higher OC expression was observed on BioOss® scaffolds. Both osteogenically differentiated and undifferentiated cell lines expressed ALP activity on the scaffolds.Conclusion: Isolated maxillary cells demonstrate multipotent in vitro characteristics comparable with those of BM‐stromal cells. HPL can predictably be used for clinical‐scale expansion of MMCs. Both grafting materials provide potential carrier characteristics when loaded with MMCs. To cite this article:
Payer M, Lohberger B, Stadelmeyer E, Bartmann C, Windhager R, Jakse N. Behaviour of multipotent maxillary bone‐derived cells on β‐tricalcium phosphate and highly porous bovine bone mineral. Clin. Oral Impl. Res. 21, 2010; 699–708. doi: 10.1111/j.1600‐0501.2009.01856.x
Evaluation of the visibility and the course of the mandibular incisive canal and the lingual foramen using cone‐beam computed tomography
Authors: Makris Nikos , Stamatakis Harry , Syriopoulos Kostas , Tsiklakis Kostas , Van Der Stelt Paul F. 
Published: April 2010

AbstractObjectives: To assess the visibility and the course of the incisive canal and the visibility and the location of the lingual foramen using cone‐beam computed tomography (CBCT).Methods: In total, 100 CBCT examinations of patients for preoperative planning were used for this study. The examinations were taken using the NewTom 3G CBCT unit, applying a standardized exposure protocol. Image reconstruction from the raw data was performed using the NewTom software. Three experts were asked to assess the visibility of the incisive canal using a four‐point rating scale. The position of the incisive canal was recorded in relation to the lower, buccal and lingual border of the mandible using the application provided by the CBCT software.Results: The incisive canal was definitely visible in 83.5% of the scans and the mean endpoint was approximately 15 mm anterior to the mental foramen. The mean distance from the lower border of the mandible was 11.5 mm and its course was closer to the buccal border of the mandible in 87% of the scans. The lingual foramen was definitely visible in 81% of the scans.Conclusions: The high detection rate of the incisive canal and the lingual foramen in the anterior region of the mandible using CBCT indicates the potentional high preoperative value of CBCT scan for surgical procedures in the anterior mandible. To cite this article: Makris N, Stamatakis H, Syriopoulos K, Tsiklakis K, van der Stelt PF. Evaluation of the visibility and the course of the mandibular incisive canal and the lingual foramen using cone‐beam computed tomography. Clin. Oral Impl. Res. 21, 2010; 766–771. doi: 10.1111/j.1600‐0501.2009.01903.x
A comparison between immediate loading and immediate restoration in cases of partial posterior mandibular edentulism: a 3‐year randomized clinical trial
Authors: Degidi Marco , Nardi Diego , Piattelli Adriano 
Published: April 2010

AbstractObjective: The aim of this study was to compare the survival rate, the bone loss and soft‐tissue healing patterns of immediately loaded and immediately restored implants in cases of partial posterior mandibular edentulism.Material and methods: Fifty patients with partial posterior mandibular edentulism were randomly selected for two treatments: 25 were included in the immediate loading group (test) and 25 in the immediate restoration group (control). All implants were placed in healed sites with a torque of >25 N cm. The temporary prosthesis of the immediate restoration group was placed so as to avoid occlusal contact in centric and lateral excursions. Both groups received fully occluding final restorations 6 months after surgery. Mean marginal bone loss was assessed at 6‐, 12‐, 24‐ and 36‐month follow‐up examinations by a blinded examiner.Results: A total of 100 implants were placed in the period between February 2004 and October 2006, of which 42 (42%) were for men and 58 (58%) for women. Five and 7 weeks after surgery, mobility of one implant was assessed in one (4%) patient in the test group and one (4%) patient in the control group, respectively. At the 36‐month follow‐up, the accumulated mean marginal bone loss was 0.987 mm (SD=0.375) for the immediate restoration group (n=48) and 0.947 mm (SD=0.323) for the immediate loading group (n=48). There was no statistically significant difference (P>0.05) for the tested outcome measures between the two procedures.Conclusions: This study was unable to detect any statistically significant difference in the survival rate, bone loss and soft tissue healing patterns between the immediately loaded and the immediately restored implants in cases of partial posterior mandibular edentulism. The immediate temporary rehabilitation of the partially edentulous posterior mandible is a predictable procedure using both procedures. To cite this article:
Degidi M, Nardi D, Piattelli A. A comparison between immediate loading and immediate restoration in cases of partial posterior mandibular edentulism: a 3‐year randomized clinical trial. Clin. Oral Impl. Res. 21, 2010; 682–687. doi: 10.1111/j.1600‐0501.2009.01910.x
Parathyroid Hormone Variability Parameters for Identifying High Turnover Osteodystrophy Disease in Hemodialysis Patients: An Observational Retrospective Cohort Study
Authors: De Paola Luciano , Coppolino Giuseppe , Bolignano Davide , Buemi Michele , Lombardi Luigi 
Published: April 2010

AbstractAbnormalities in bone morphology that develop secondary to chronic kidney disease are defined as renal osteodystrophy and are identified by bone biopsy. As systematic and sequential bone biopsy is not practicable on a large number of patients, various chemical bone markers are commonly used to detect the bone remodeling status in chronic kidney disease and to grade bone disease in the clinical setting. Recent literature has considered the effect of absolute levels of parathyroid hormone (PTH) on clinical outcomes and not the measurement of their change over time, the PTH variability. In a retrospective observational study, we examined PTH variability parameters in a group of hemodialysis patients as independent risk factors for high vs. low turnover osteopathy, and investigated their usefulness with respect to commonly used markers of renal osteodystrophy. The study was conducted on 90 chronic hemodialysis patients undergoing regular treatment at the same dialysis centre (Catanzaro, Italy) with standard bicarbonate dialysis. Patients were classified into either high or medium–low turnover osteopathy for the diagnosis based on renal osteodystrophy using the following criteria: PTH ≥ 400 pg/mL associated with bone ALP ≥ 20 ng/mL. We used a regression‐based measurement of PTH variability, which was characterized by different parameters: PTH‐Res‐SD, PTH‐Slope, PTH‐Intercept, PTH‐Abs‐Var, and PTH‐Res‐SD. In our analysis, these parameters of PTH variability were demonstrated to be good independent predictive factors for high turnover osteodystrophy, and they had a greater sensitivity than the use of a single and/or mean PTH measurements in renal osteodystrophy classification.
Prognostic Study of Cardiac and Renal Events in Japanese Patients With Chronic Kidney Disease and Cardiovascular Risk Using Myocardial Perfusion SPECT: J‐ACCESS 3 Study Design
Authors: Nakamura Satoko , Kawano Yuhei , Hase Hiroki , Hatta Tsuguru , Nishimura Shigeyuki , Moroi Masao , Nakagawa Susumu , Kasai Tokuo , Kusuoka Hideo , Takeishi Yasuchika , Nakajima Kenichi , Momose Mitsuru , Takehana Kazuya , Nanasato Mamoru , Yoda Syunichi , Nishina Hidetaka , Matsumoto Naoya , Nishimura Tsunehiko 
Published: April 2010

AbstractCardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease. Recent studies have indicated that the incidence of cardiovascular disease increases inversely with estimated glomerular filtration rate. Although coronary angiography is considered the gold standard for detecting coronary artery disease, contrast‐induced nephropathy or cholesterol microembolization remain serious problems; therefore, a method of detecting coronary artery disease without renal deterioration is desirable. From this viewpoint, stress myocardial perfusion single photon emission computed tomography (SPECT) might be useful for patients with chronic kidney disease. We recently performed the Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J‐ACCESS) investigating patients with suspected or extant coronary artery disease and the J‐ACCESS 2 study of patients with diabetes. The findings from these studies showed that SPECT can detect coronary artery disease and help to predict future cardiac events. Thus, we proposed a multicenter, prospective cohort study called “J‐ACCESS 3” in patients with chronic kidney disease and cardiovascular risk. The study aimed at predicting cardiovascular and renal events based on myocardial perfusion imaging and clinical backgrounds. We began enrolling patients in J‐ACCESS 3 at 74 facilities from April 2009 and will continue to do so until 31 March 2010, with the aim of having a cohort of 800 patients. These will be followed up for three years. The primary endpoints will be cardiac death and sudden death. The secondary endpoints will comprise any cardiovascular or renal events. This study will be completed in 2013. Here, we describe the design of the J‐ACCESS 3 study.
Removal of Humoral Mediators and the Effect on the Survival of Septic Patients by Hemoperfusion With Neutral Microporous Resin Column
Authors: Huang Zhao , Wang Si‐Rong , Su Wei , Liu Ji‐Yun 
Published: April 2010

AbstractThe aim of this study is to evaluate the impact of neutral microporous resin hemoperfusion on hemodynamic improvement, removal of inflammatory cytokines, and mortality in critical care patients with severe sepsis. Forty‐four patients with severe sepsis or septic shock were randomized to HA type hemoperfusion treatment (N = 24) or standard therapy (N = 20). Those undergoing hemoperfusion treatment received HA330 hemoperfusion. We measured the plasma concentrations of IL‐6 and IL‐8 at the start of every hemoperfusion treatment, and the following parameters were compared between the control group and the hemoperfusion group on days 3, 7, and 14: hemodynamics (cardiac index, systemic vascular resistance index, heart rate, and mean arterial pressure); change of hematology and coagulation function; organ function; and the sequential organ failure assessment (SOFA) score. Hospital, 28‐day, and ICU mortality were also observed. Patients treated with HA hemoperfusion showed a significant removal of plasma IL‐6 and IL‐8 over time while in the study. Patients in the HA group also demonstrated significant increases in cardiac index, systemic vascular resistant index, fast withdrawal of vasoactive agents and decreases in heart rate compared with the controls at days 3 and 7. Although there was no significant difference between the groups in organ dysfunction as assessed by SOFA scores from day 0 (baseline) to day 7, significant improvement can be demonstrated in the hemoperfusion group at day 14. There was no significant difference between the groups in 28‐day mortality, hospital mortality, or length of hospital stay, but ICU mortality and the length of ICU stay in the HA group were markedly reduced. Hemoperfusion treatment using the HA type cartridge in sepsis is safe and it may improve organ dysfunction, ICU mortality, and shorten the length of ICU stay. Clinical significant removal of inflammatory cytokines such as IL‐6 and IL‐8 from circulation by hemoperfusion may contribute to improving a patient's outcome in an ICU.
Incidence and Clinical Outcomes of Acute Kidney Injury Requiring Renal Replacement Therapy in Japan
Authors: Yasuda Hideo , Kato Akihiko , Fujigaki Yoshihide , Hishida Akira ,   the Shizuoka Kidney Disease Study Group
Published: April 2010

AbstractNo population‐based studies have described the prevalence of acute kidney injury (AKI) treated with renal replacement therapy (RRT) in Japan. This study prospectively examined the incidence of AKI requiring RRT by surveying 16 hospitals in Shizuoka prefecture from January to October 2006. The subjects comprised 242 patients treated with RRT during the observation period. The estimated incidence of AKI requiring RRT was 13.3 cases/100 000 persons/year in this area. Major contributing factors for AKI were sepsis (34%), cardiac shock (23%), and major surgery (12%). The in‐hospital mortality rate was 47.1%, paralleling the increased number of insufficient organs. Oliguria was a risk factor for in‐hospital mortality. These findings suggest that the incidence of AKI treated with RRT in Japan is comparable to those in Western countries, and the prognosis of AKI patients requiring RRT is also poor in Japanese patients.
DIFFERENT SWEETENERS IN BEVERAGES PREPARED WITH INSTANT AND ROASTED GROUND COFFEE: IDEAL AND EQUIVALENT SWEETNESS
Authors: TREVIZAM MORAES PATRÍCIA CARLA BARBOSA , BOLINI HELENA MARIA ANDRÉ 
Published: April 2010

ABSTRACTNowadays, people are increasingly concerned about their health and appearance, and have sought feeding alternatives to the main problems that affect world population, such as obesity and diabetes, that share a close relation with high sucrose consumption.This study determined the ideal sweetness in beverages prepared with instant coffee and roasted ground coffee, using a “just about right” scale, and the equivalent sweetness of samples sweetened with sucralose, stevia, aspartame, cyclamate/saccharin (2:1), acesulfame K, by using the Magnitude Estimation.Sucrose concentration considered ideal by consumers for instant coffee beverages was 9.5%, with sweetener concentrations equivalent to 0.01494% for sucralose; 0.09448% for stevia; 0.05064% for aspartame; 0.04967% for acesulfame K; and 0.0339% for a cyclamate/saccharin (2:1) blend.Sucrose concentration considered ideal by consumers for roasted ground coffee beverages was 12.5%, with sweetener concentrations equivalent to 0.0209% for sucralose; 0.0166% for stevia; 0.0724% for aspartame; 0.0640% for acesulfame K; 0.0582% for cyclamate/saccharin (2:1) blend.PRACTICAL APPLICATIONSThis study may serve as a guide for the food industry that aims at producing drinks or powders (instant coffee or roasted ground coffee) with the addition of sweeteners to replace sucrose, or to educate consumers about the amount of sweetener that can be added to these drinks for obtaining the ideal sweetness in relation to sucrose.This information is only possible to be obtained with the application of a sensory technique analysis, because sweeteners behavior is specific for each product type.
FORMULATION OF A SOY–COFFEE BEVERAGE BY RESPONSE SURFACE METHODOLOGY AND INTERNAL PREFERENCE MAPPING
Authors: FELBERG ILANA , DELIZA ROSIRES , FARAH ADRIANA , CALADO ERÔNICA , DONANGELO CARMEN MARINO 
Published: April 2010

ABSTRACT Coffee consumers (n = 60) tasted and rated samples of a new soy–coffee beverage made from instant coffee, soymilk powder and sugar. Ingredient concentrations (independent variables) varied according to a 23central composite design for overall degree of acceptance. Data were analyzed by analysis of variance (ANOVA), least square difference and response surface methodology, followed by internal preference mapping (IPM) with cluster analysis. ANOVA from the consumers' acceptance data revealed that samples differed significantly (P ≤ 0.05). Although soymilk content did not influence significantly the consumers' acceptance in the tested range, IPM with cluster analysis indicated that at least part of the acceptance differences was based on the soy beverage consumption habit. The final beverage formulation was evaluated cold and hot for overall acceptability (9‐point structured hedonic scale) by 112 coffee consumers and the cold beverage reached a good acceptability mean score (6.2) among the participants.PRACTICAL APPLICATIONSThe consumption of soy products has been reported to reduce the risk of several diseases and a number of recent studies have found beneficial health properties attributed to coffee. Considering the current consumer trend for healthier alternatives in food products, we decided to combine the health benefits of these two important Brazilian commodities in a functional beverage. In order to optimize the formulation and maximize sensory acceptance, we performed consumers' tests using response surface methodology. Internal preference mapping and cluster analyses were also applied to provide information on the variability of the consumer individual opinions and segment them in groups of similar preference criteria.
A COMPARISON OF THE LABELED AFFECTIVE MAGNITUDE SCALE AND THE 9‐POINT HEDONIC SCALE AND EXAMINATION OF CATEGORICAL BEHAVIOR
Authors: LAWLESS HARRY T. , SINOPOLI DOMINIQUE , CHAPMAN KATHRYN W. 
Published: April 2010

ABSTRACT Two experiments compared the performance of the 9‐point hedonic scale with the labeled affective magnitude (LAM) scale for food acceptability ratings of a well‐liked food (potato chips). Both scales performed well in discriminating products. Both scales uncovered a strong relationship between usage patterns and acceptance ratings. Both scales found a significant product by user group interaction effect that showed a consistent pattern of the type of chip consumed versus acceptance ratings. The 9‐point scale showed somewhat higher reliability as measured by the correlation of scores for a duplicate product. “Categorical” usage of the LAM scale, defined as making ratings within ±1–2 mm of a word phrase (depending upon the line length, approximately 1% of scale range), was observed here as seen previously. Use of a physically longer line (200 mm versus 116 mm) decreased the frequency of such categorical ratings. These results showed no strong advantage to either scaling method. The categorical use of the LAM scale may depend in part upon the physical appearance of the scale. PRACTICAL APPLICATIONSDifferent scales have been used for examining acceptability of foods. Using scales with high discriminative power, good reliability and some predictive value for correlating with food habits is a goal of sensory evaluation. Better scales may help show differences among new consumer products and avoid type II error (missing a difference, and/or not identifying a business risk or an opportunity).
CONSUMER PERCEPTION AND PREFERENCE OF BOTTLED AND TAP WATER
Authors: TEILLET ERIC , URBANO CHRISTINE , CORDELLE SYLVIE , SCHLICH PASCAL 
Published: April 2010

ABSTRACT In order to understand consumer behavior toward drinking water, it is first necessary to determine sensory perception and liking for tap and bottled water. Nevertheless, sensory analysis of water is a challenge as drinking water is supposed to have almost no taste. Therefore, a methodology based on a perceptive sorting task was designed for that purpose. Six bottled mineral water and six types of tap water were presented to 389 consumers who had to group these samples according to their sensory similarities, describe their groups and give their preferences. The resulting sensory map was found to be mainly driven by the overall level of mineralization. Tap water, after being passively dechlorinated, did not perform differently from bottled water in all aspects for most consumers. Basically, three main tastes of water were highlighted and linked to the amount of minerals. The study demonstrated that the most likely preferred types of water are those with medium mineralization (total dissolved solids 300–350 mg/L), which are perceived as tasteless and cooler. PRACTICAL APPLICATIONSPractical use of the research presented in the present article is in water industry. This study enabled to understand the basis of consumers' perception and preference among drinking water and is a starting point in understanding consumers' behavior toward drinking water. There is also a methodological interest in the use of sorting tasks associated with preference ratings, which demonstrated its efficiency in assessing the links between perception and preference in water.
EFFECT OF MILK PASTEURIZATION ON FLAVOR PROPERTIES OF SEVEN COMMERCIALLY AVAILABLE FRENCH CHEESE TYPES
Authors: CHAMBERS DELORES H. , ESTEVE EMILIEN , RETIVEAU ANNYLSE 
Published: April 2010

ABSTRACT Previous research on matched pairs of experimental cheese showed that heat treatment of milk affected flavor properties. However, whether pasteurization has a generalized effect or whether the effect is specific to certain cheese varieties is not known. Experienced, highly trained sensory panelists developed flavor profiles for seven commercially available French cheeses (Brie, Coulommier, Camembert, Saint Nectaire, Muenster, Chèvre and Bleu) for which versions made from pasteurized or unpasteurized milk were commercially available. Raw‐milk cheese had stronger odor properties. Soft cheeses with white rind (Brie, Coulommier, Camembert and Saint Nectaire) as well as Chèvre and Bleu were affected similarly by heat treatment of milk, but the sensory characteristics of Muenster cheese did not follow the pattern of other cheeses. These results suggest that many, but not all, cheese types show similar changes in sensory attributes as a result of using pasteurized rather than raw milk. PRACTICAL APPLICATIONSThis study gives manufacturers and researchers information on flavor differences that exist between similar cheese types made from raw or pasteurized milk. Researchers and manufacturers can use that information in order to develop pasteurized‐milk cheese that has the traditional full‐flavored characteristics of its raw‐milk counterpart.