bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of a superabsorbent hydrogel from Artocarpus heterophyllus Lam seed polysaccharides and its application in relieving drought stress in plants
Authors: Krishnasamy Ravindran , Obbineni Jagan M. 
Published: June 2024

AbstractSustainability in agriculture can only be achieved by protecting important resources, one of them being water. Availability of water in the soil greatly influences agricultural productivity. Hydrogels play a key role in ensuring water availability and achieving agricultural sustainability. A novel superabsorbent hydrogel was synthesized from Artocarpus heterophyllus Lam seed polysaccharides. The synthesized hydrogel was characterized using Fourier transform infrared spectroscopy, X‐ray diffraction, thermogravimetric analysis, and scanning electron microscopy. Swelling capacity of the hydrogel in different solutions, water retention duration, its influence on the soil water holding capacity (SWHC), and degradation in soil were assessed. The hydrogel absorbs up to 326 g/g and degrades naturally at around 1.4 wt% daily. The hydrogel improved the SWHC by 34% at a concentration of 0.3% w/w. Further pot experiments with black gram (Vigna mungo (L.) Hepper) plants showed that the superabsorbent hydrogel ensured water availability for 35 days and relieved the plants from drought‐induced stress. The data presented here indicates that the synthesized hydrogel can potentially be used as a soil conditioner for the sustained release of water and fertilizer.
Pharmacophore‐based, rationale design, and efficient synthesis of novel tetrahydrobenzo[b]thiophene candidates as potential dual Topo I/II inhibitors and DNA intercalators
Authors: Nofal Hager R. , Al‐Karmalawy Ahmed A. , Elmaaty Ayman Abo , Ismail Mahmoud F. , Ali Ali Khalil , Abbass Eslam M. 
Published: June 2024

AbstractA series of tetrahydrobenzo[b]thiophene derivatives was designed and synthesized as dual topoisomerase (Topo) I/II inhibitors implicating potential DNA intercalation. Ethyl‐2‐amino‐3‐cyano‐4,5,6,7‐tetrahydrobenzo[b]thiophene‐4‐carboxylate (1) was prepared by modification of the Gewald reaction procedure using a Fe2O3 nanocatalyst and then it was used as a building block for the synthesis of tetrahydrobenzo[b]thiophene candidates (2–14). Interestingly, compound 14 showed the best cytotoxic potential against hepatocellular, colorectal, and breast cancer cell lines (IC50 = 7.79, 8.10, and 3.53 µM), respectively, surpassing doxorubicin at breast cancer (IC50 = 4.17 µM). Meanwhile, the Topo I and II inhibition assay displayed that compound 3 could exhibit the best inhibitory potential among the investigated candidates (IC50 = 25.26 and 10.01 nM), respectively, in comparison to camptothecin (IC50 = 28.34 nM) and doxorubicin (IC50 = 11.01 nM), as reference standards. In addition, the DNA intercalation assay showed that compound 14 could display the best binding affinity with an IC50 value of 77.82 µM in comparison to doxorubicin (IC50 = 58.03 µM). Furthermore, cell cycle and apoptosis analyses described that compound 3 prompts the G1 phase arrest in michigan cancer foundation‐7 cancer cells and increases the apoptosis ratio by 29.31% with respect to untreated cells (2.25%). Additionally, the conducted molecular docking assured the promising binding of the investigated members toward Topo I and II with potential DNA intercalation. Accordingly, the synthesized compounds could be treated as promising anticancer candidates for future optimization.
Exposure assessment and cytogenetic biomonitoring study of workers occupationally exposed to extremely low‐frequency magnetic fields
Authors: Nguyen Ha , Vandewalle Giovani , Mertens Birgit , Collard Jean‐Francois , Hinsenkamp Maurice , Verschaeve Luc , Feipel Veronique , Magne Isabelle , Souques Martine , Beauvois Véronique , Ledent Maryse 
Published: June 2024

AbstractHuman cytogenetic biomonitoring (HCB) has long been used to evaluate the potential effects of work environments on the DNA integrity of workers. However, HCB studies on the genotoxic effects of occupational exposure to extremely low‐frequency electromagnetic fields (ELF‐MFs) were limited by the quality of the exposure assessment. More specifically, concerns were raised regarding the method of exposure assessment, the selection of exposure metrics, and the definition of exposure group. In this study, genotoxic effects of occupational exposure to ELF‐MFs were assessed on peripheral blood lymphocytes of 88 workers from the electrical sector using the comet and cytokinesis‐block micronucleus assay, considering workers' actual exposure over three consecutive days. Different methods were applied to define exposure groups. Overall, the summarized ELF‐MF data indicated a low exposure level in the whole study population. It also showed that relying solely on job titles might misclassify 12 workers into exposure groups. We proposed combining hierarchical agglomerative clustering on personal exposure data and job titles to define exposure groups. The final results showed that occupational MF exposure did not significantly induce more genetic damage. Other factors such as age or past smoking rather than ELF‐MF exposure could affect the cytogenetic test outcomes.
Fabrication of a decellularized liver matrix–based hepatic patch for the repair of CCl4‐induced liver injury
Authors: Wu Ting‐Yi , Hsieh Yi‐Cheng , Yin Wei‐Rong , Cheng Kai‐Yi , Hou Yung‐Te 
Published: June 2024

AbstractThis article primarily introduces a new treatment for liver fibrosis/cirrhosis. We developed a hepatic patch by combining decellularized liver matrix (DLM) with the hepatocyte growth factor (HGF)/heparin–complex and evaluated its restorative efficacy. In vitro prophylactic results, the HGF/heparin–DLM patches effectively mitigated CCl4‐induced hepatocyte toxicity and restored the cytotoxicity levels to the baseline levels by day 5. Furthermore, these patches restored albumin synthesis of injured hepatocytes to more than 70% of the normal levels within 5 days. In vitro therapeutic results, the urea synthesis of the injured hepatocytes reached 91% of the normal levels after 10 days of culture, indicating successful restoration of hepatic function by the HGF/heparin–DLM patches in both prophylactic and therapeutic models. In vivo results, HGF/heparin–DLM patches attached to the liver and gut exhibited a significant decrease in collagen content (4.44 times and 2.77 times, respectively) and an increase in glycogen content (1.19 times and 1.12 times, respectively) compared to the fibrosis group after 1 week, separately. In summary, liver function was restored and inflammation was inhibited through the combined effects of DLM and the HGF/heparin–complex in fibrotic liver. The newly designed hepatic patch holds promise for both in vitro and in vivo regeneration therapy and preventive health care for liver tissue engineering.
Development of the IMP biosensor for rapid and stable analysis of IMP concentrations in fermentation broth
Authors: Jiang Shibo , Lin Ying , Zheng Suiping 
Published: June 2024

AbstractIMP (inosinic acid) is a crucial intermediate in the purine metabolic pathway and is continuously synthesized in all cells. Besides its role as a precursor for DNA and RNA, IMP also plays a critical or essential role in cell growth, energy storage, conversion, and metabolism. In our study, we utilized the circularly permuted fluorescent protein (cpFP) and IMP dehydrogenase to screen and develop the IMP biosensor, IMPCP1. By introducing a mutation in the catalytically active site of IMPCP1, from Cys to Ala, we disrupted its ability to catalyze IMP while retaining its capability to bind to IMP without affecting the IMP concentration in the sample. To immobilize IMPCP1, we employed the SpyCatcher/SpyTag system and securely attached it to Magarose‐Epoxy, resulting in the development of the IMP rapid test kit, referred to as IMPTK. The biosensor integrated into IMPTK offers enhanced stability, resistance to degradation activity, and specific recognition of IMP. It is also resistant to peroxides and temperature changes. IMPTK serves as a rapid and stable assay for analyzing IMP concentrations in fermentation broth. Within the linear range of IMP concentrations, it can be utilized as a substitute for HPLC. The IMPTK biosensor provides a reliable and efficient alternative for monitoring IMP levels, offering advantages such as speed, stability, and resistance to environmental factors.
Radiotherapeutic outcomes of Rosai–Dorfman disease with falx cerebri and superior sagittal sinus involvement: A rare case report with long‐term follow‐up
Authors: Nasrollahi Hamid , Andalibi Susan , Ansari Mansour , Mokhtari Maral , Hosseini Ehsan Mohammad , Foroughi Mina , Sourani Arman 
Published: June 2024

Key Clinical MessageIntracranial RDD is rare medical event mimicking different diagnoses. Although the surgical resection is the best treatment option, but radiation therapy can also achieves long‐term suboptimal outcomes.AbstractAn 83‐year‐old male with a history of tension‐type headaches was evaluated. He was conscious with no focal neurological deficits. His brain MRI revealed an enhancable bifrontal tumor originating from falx cerebri and superior sagittal sinus dura. Due to the patient's preference and decline for gross total resection, she underwent a stereotactic biopsy. The pathology was positive for Rosai–Dorfman diseases. He received definitive targeted radiation with a total dose of 4500 cGy administered in 200 cGy daily fractions. His 4‐year follow‐up showed regional tumor control with excellent neurological outcome.
Native and prosthetic valve infective endocarditis complicated by rapidly progressive glomerulonephritis and its diagnostic challenges and therapeutic implications
Authors: Getachew Yitagesu , Getahun Zerubabel , Wondafrash Getachew , Asmare Zemenay , Solela Gashaw , Aberra Beka , Daba Merga 
Published: June 2024

Key Clinical MessageConcomitant native and prosthetic valve infective endocarditis (IE) is very rare, and both can rarely be complicated by rapidly progressive glomerulonephritis (RPGN). This diagnosis has therapeutic implications, as not all RPGN need immunosuppression therapy.AbstractNative and prosthetic valve infective endocarditis (IE) may be rarely complicated by rapidly progressive glomerulonephritis (RPGN). The diagnosis of IE as a cause of RPGN may be missed, and patients may be subjected to inappropriate immune suppressive therapy. Moreover, IE involving multi‐valves has rarely been described, and there are only few case reports of simultaneous native and prosthetic valve endocarditis. Here, we present a case of 34‐year‐old female patient who has RPGN and whose initial workup missed IE. However, further workup revealed a diagnosis of native and prosthetic valve IE and our patient, who would have been subjected to inappropriate immune suppressive therapy, was treated with intravenous antibiotics alone and discharged with improvement.
Autopsy findings in a rare case of pleomorphic carcinoma in a patient on dialysis
Authors: Okada Keiichiro , Kita Serina , Yamanouchi Hirotaka , Nakao Shinichiro , Matsuda Yuto , Kusuno Yui , Nomura Kazutoshi , Yabe Tomohisa , Hayashi Norifumi , Fujimoto Keiji , Furuichi Kengo 
Published: June 2024

Key Clinical MessagePleomorphic lung cancer is a very rare type of cancer and very few cases have been reported in the literature. We present a case of pleomorphic lung cancer in a patient with history of IgA nephropathy on hemodialysis.
Use of pulse field ablation in the treatment of an atrial tachycardia: A case report
Authors: Elbanhawy Noha 
Published: June 2024

Key Clinical MessageThis case illustrates the safety and efficacy of pulse field ablation (PFA) in the short and medium term. It could be used to isolate extra pulmonary sites including the posterior wall. PFA could be used in the treatment of atrial tachycardias both focal and reentrant in combination with ultrahigh density electroanatomic mapping. It is also important to understand that different catheter shapes are available and their use can be tailored to the targeted anatomical site.
Unusual giant plunging sublingual epidermoid cyst: A case report and review of literature
Authors: Safwan Mohamad , Godbole Aditya Amit , Médéus Arens Jean Ricardo , García‐González Oxiris Yexalén , Sanker Vivek , Prashanth Polasu Sri Satya Sai , Dave Tirth 
Published: June 2024

Key Clinical MessageWhen treating a painless or asymptomatic mass in the submental or floor of the mouth, sublingual epidermoid cyst should be considered. Despite its irregularity, preventing malignant transformation is essential for a successful outcome.AbstractDermoid and epidermoid cysts are rarely found in the head and neck region. They account for less than 0.01% of all oral cavity cysts. This is a rare case of a sublingual epidermoid cyst of the oral cavity in a 25‐year‐old male. The patient presented with a painless sublingual swelling for a duration of 1 month. The clinical examination revealed a non‐tender swelling in the sublingual region extending to the submental triangle. Magnetic resonance imaging confirmed a 6.2 × 7.7 × 3.2 cm cystic lesion in the sublingual space. Fine needle aspiration cytology confirmed dermoid cyst contents. Intra‐oral surgical excision under general anesthesia was performed successfully. Histopathological analysis revealed that the cyst wall was lined by stratified squamous epithelium. The presence of a prominent granular layer and keratin flakes confirmed the diagnosis of an epidermoid cyst. Postoperative recovery was good, and no recurrence was observed during follow‐up. This case emphasizes the infrequent and unusual presentation of a case of a giant plunging sublingual epidermoid cyst and promotes awareness and potential studies in the enhancement of patient care in this area.
Cocaine, amphetamine, or titin: Unraveling the genetic underpinnings of dilated cardiomyopathy
Authors: Panjiyar Binay Kumar , Changlani Nikita , Medina Clarisa , Trevino Lisa R. 
Published: June 2024

Key Clinical MessageAn interesting case that shows the importance of identifying a pathogenic TTN gene mutation through genetic assessment in unexplained cardiomyopathy, especially with family history. This case highlights the need for genetic counseling and testing for at‐risk relatives, and advocates for personalized management considering both genetic and lifestyle factors.AbstractThis case report examines a 33‐year‐old Hispanic male with bipolar disorder, schizophrenia, and a history of substance use, presenting with acute respiratory failure and cardiac arrest. The patient's nonischemic dilated cardiomyopathy (DCM) highlights the critical role of genetic factors, particularly titin gene (TTN) mutations, in cardiomyopathy pathogenesis. Through genetic analysis, we explore the intersection of lifestyle factors and genetic predisposition in DCM, underscoring the importance of comprehensive genetic testing for accurate diagnosis and targeted therapy. This case contributes to the evolving understanding of DCM etiology, emphasizing the necessity of considering both environmental and genetic factors in clinical assessment and management.
Using Phosphonic Acid Monolayers to Control CO2 Adsorption and Hydrogenation on Pt/Al2O3
Authors: Blanchette Zachary , Zhou Xinpei , Schwartz Daniel K. , Medlin J. Will 
Published: June 2024

AbstractPhosphonic acid (PA) self‐assembled monolayers (SAMs) were deposited onto Pt/Al2O3 catalysts to modify the support to enable control over CO2 adsorption and CO2 hydrogenation activity. Significant differences in catalytic activity toward CO2 hydrogenation (reverse water‐gas shift, RWGS) were observed after coating Al2O3 with PAs, suggesting that the reaction was mediated by CO2 adsorption on the support. Amine‐functionalized PAs were found to outperform their alkyl counterparts in terms of activity, however there was little effect of amine location in the SAM (i. e., spacing between the amine functional group and phosphonate attachment group). One amine‐PA and one alkyl‐PA, aminopropyl phosphonic acid (C3NH2PA) and methyl phosphonic acid (C1PA), respectively, were investigated in more detail. The C3NH2PA‐modified catalyst was found to bind CO2 as a combination of carbamate and bicarbonate. Additionally, at 30 °C, both PAs were found to reduce CO2 adsorption uptake by approximately 50 % compared to unmodified 5 %Pt/Al2O3. CO2 adsorption enthalpy was measured for the catalysts and found to be strongly correlated with hydrogenation activity, with the trend in binding enthalpy and CO2 hydrogen rate trending as uncoated >C3NH2PA>C1PA. PA SAMs were found to have weaker effects on CO binding and CO selectivity, consistent with selective modification of the Al2O3 support by the PAs.
Advancements in Dry Electrode Technologies: Towards Sustainable and Efficient Battery Manufacturing
Authors: Jin Wooyoung , Song Gyujin , Yoo Jung‐Keun , Jung Sung‐Kyun , Kim Tae‐Hee , Kim Jinsoo 
Published: June 2024

AbstractTo address the urgent demand for sustainable battery manufacturing, this review contrasts traditional wet process with emerging dry electrode technologies. Dry process stands out because of its reduced energy and environmental footprint, offering considerable economic benefits and facilitating the production of high‐energy‐density electrodes. We spotlight technological innovations that exemplify the paradigm shift towards eco‐friendliness and cost‐efficiency. This review synthesizes the latest developments in dry electrode production, comparing the techniques with conventional methods, and outlines future research for further optimization toward a higher technology readiness level. We suggest that the evolution of battery manufacturing hinges on the synergy between process innovation and materials science, which is crucial for meeting the dual goals of environmental sustainability and economic practicality.
Oxygen‐Promoted on‐Surface Synthesis of Polyboroxine Molecules
Authors: Toffoli Daniele , Turco Elia , Stredansky Matus , Costantini Roberto , Dell'Angela Martina , Floreano Luca , Goldoni Andrea , Morgante Alberto , Kladnik Gregor , Cvetko Dean , de Oteyza Dimas G. , Colazzo Luciano , Mohammed Mohammed S. G. , Sala Alessandro , Comelli Giovanni , Africh Cristina , Fronzoni Giovanna , Balducci Gabriele , Stener Mauro , Ustunel Hande , Cossaro Albano 
Published: June 2024

AbstractWe present a protocol for the on‐surface synthesis of polyboroxine molecules derived from boroxine molecules precursors. This process is promoted by oxygen species present on the Au(111) surface: oxygen atoms facilitate the detachment of naphthalene units of trinaphthyl‐boroxine molecules and bridge two unsaturated boroxine centers to form a boroxine‐O‐boroxine chemical motif. X‐ray spectroscopic characterization shows that, as the synthesis process proceeds, it progressively tunes the electronic properties of the interface, thus providing a promising route to control the electron level alignment.
Multi Stimuli Responsive Dual Aggregation‐Induced Emission and Photochromic Behavior of a Tetraphenyl Substituted Triphenylamine Derivative and its Application as Anti‐counterfeiting Agent
Authors: Bokotial Dikshit , Bhattacharyya Soumalya , Arunkumar S. , Das Trisha , Mini Rajendran Gokul Raj , Chowdhury Aniket 
Published: June 2024

AbstractA multi‐stimuli responsive tetraphenyl substituted tripehnylamine‐based aggregation induced emissive (AIE) material coupled with spiropyran was prepared. Owing to the presence of AIE and photochromic moiety, the molecule exhibits emissive aggregates, photochromism, and acidochromism. The multiple stimuli sensitive behavior of the molecule was explored for anti‐counterfeiting behavior on TLC plate and commercial banknotes. The fluorogenic and photogenic response under UV and visible light established the potential of the candidate as a new generation encryption material.
Changes in the Crystal Lattice Parameters of Bismuth Films on Substrates with Different Thermal Expansion
Authors: Suslov Anton , Gerega Vasilisa , Rodionov Arkadi , Fedoseev Mikhail , Komarov Vladimir , Grabov Vladimir 
Published: June 2024

AbstractDue to the sensitivity of the electronic structure of semi‐metals to small distortions of the crystal lattice, the study of the electrical and galvanomagnetic properties of bismuth films requires taking into account the deformation that occurs in the film‐substrate system due to the difference in the thermal expansion of the film and substrate materials. The magnitude of these deformations plays an important role in analyzing the temperature dependencies of the transport properties of charge carriers. The paper presents an experimental study of the magnitude of deformation of bismuth films on various substrates at 300 and 77 K using X‐ray diffraction. Changes in the lattice constant of crystallites, the trigonal axis of which is perpendicular to the film plane, depending on the substrate material, are obtained. A comparison between the assessment of the deformation of these crystallites in the film plane based on Hooke's law and the difference in the coefficients thermal expansion of the film and substrate materials is made.
Opto‐Electronic Properties of Gap1‐xSbx Alloys for IR Applications
Authors: Chaudhary Priya , Rathi Amit , Singh Amit Kumar 
Published: June 2024

AbstractThe full potential linearized augmented plane wave (FP‐LAPW) method is used to compute structural, electronic, and optical properties of III‐V semiconductor ternary alloys GaP1‐xSbx (0≤x≤1) using first‐principle calculations within density functional theory. To calculate the ground state parameters of the structure, the energy exchange‐correlation Wu‐cohen generalized gradient approximation is employed in the wiek2k program. The Tran–Blaha‐modified Becke–Johnson (TB‐mBJ) pseudopotential is employed in addition to the Wu‐Cohen generalised gradient approximation to achieve a precise bandgap. After this, WC‐mBJ is used to examine optical properties such as real and imaginary parts of the dielectric constant, and energy loss. This study illustrates the nonlinear dependency on the various Sb compositions by examining the composition impacts on the bandgap, bulk modulus, and lattice constant. Using WC‐mBJ, the estimated band structures for alloys GaP0.75Sb0.25, GaP0.50Sb0.50, and GaP0.25Sb0.75 show direct energy bandgaps of 2.008 eV (617 nm), 1.482 eV (836 nm), and 1.055 eV (1174 nm), respectively. As a result, this material system has enormous potential for use in applications spanning the visible to infrared spectrum.