bluuebunny/crossref_metadata_2025_split huggingface dataset:
Andean Lima Bean Ecology and Its Potential Contribution to Food Security
Authors: Gavilan‐Figari Isabel Milagros , Inga Marianela , Betalleluz‐Pallardel Indira , Espinoza de Arenas Luz Marina , Comettant‐Rabanal Raúl 
Published: May 2024

ABSTRACTThe Andean lima bean (ALB) (Phaseolus lunatus L.), also known as “Pallar” in Peru, is a large, semi‐flat, kidney‐shaped rarely investigated legume. This ancestral legume lacks in‐depth scientific reports and is mainly cultivated in the coastal region of the Ica valley. Its consumption dates back to ancient times, as evidenced by archaeological finds from pre‐Columbian civilizations in Peru, and it is still part of the Peruvian diet today. ALB has been domesticated and adapted to climate change in arid territories and under peculiar agronomic conditions in Peru, making the crop tolerant to various stresses, including drought. Like the common bean, ALB is an important source of protein, carbohydrates, dietary fiber, and micronutrients that are essential for a nutritious diet. However, the information on its diversity, particularly the native varieties that are the ancestors of the commercial lima bean “Pallar de Ica,” is scarce. Therefore, this review consisted of synthesizing and analyzing important aspects of the little known ALB, such as its morphological description, domestication, response to climate change, nutritional composition, and relevance to food security and potential for cultivation to address food shortages.
Healthy lifestyle scales to assess general and clinical population: A systematic review with narrative synthesis
Authors: Dehghani Elaheh , Karimi Keyvan , Sokke Hananeh Ghelichi‐Moghaddam , Khadembashiri Mohammad Amin , Ghavidel Fatemeh , Memari Amir Hossein 
Published: May 2024

AbstractBackgroundAdopting a healthy lifestyle and improvements in medical care have led to an increase in life expectancy. Thus, the development and implementation of techniques for assessing healthy lifestyles have garnered more attention recently. Finding and evaluating healthy lifestyle assessment tools across all demographics is the goal of this systematic review.MethodUsing online databases PubMed, Scopus, Web of Science, and APA PsycINFO, a systematic literature review was carried out in accordance with Preferred Reporting Items for Systematic Review and Meta‐analyses. Registration DOIhttps://doi.org/10.17605/OSF.IO/ZD9XKfor the review has been set on Open Science Framework (OSF). Using the quality standards proposed for measuring features of health status surveys, two independent reviewers evaluated the methodological quality ratings of the eligible studies.ResultsFrom 7480 studies, 47 eligible instruments were identified and included in the review. Most of the studies followed the World Health Organization's definition of healthy lifestyle to develop the scales. The instruments are categorized into those used to assess general lifestyle or healthy lifestyle in general as well as in the clinical population. Physical activity, nutrition, tobacco use, alcohol use, and stress management were the most assessed modules of healthy lifestyle. Furthermore, validity, reliability, responsiveness, floor and ceiling effects, and interpretability were among the psychometric qualities that were frequently assessed.ConclusionLifestyle questionnaires can be used to identify specific risk factors in a variety of populations, as well as to plan community‐based intervention programs, by acting as a predictive diagnostic tool and preventive measure. The majority of the assessments of healthy lifestyles that are currently accessible require improvements.
Determination of the flexural properties of additively manufactured polyamide 12 components with antimicrobial titanium dioxide additives
Authors: du Maire P. , Friebertshäuser M. , Deckert M. , Johlitz M. , Öchsner A. 
Published: May 2024

AbstractAntibacterial properties of components are increasingly becoming an important challenge in material development especially in polymer technology. A well‐known additive with which an antibacterial effect can be achieved is the metal oxide titanium dioxide. The aim of this research work was to investigate possible influences on the flexural properties of additively manufactured components resulting from the addition of titanium dioxide as an antimicrobial additive. Compounds with 5 %, 10 % and 15 % titanium dioxide and polyamide 12 as matrix material were produced. Three‐point bending test specimens were fabricated out of these compounds, anaylsed and the results were compared with specimens made of virgin polyamide 12. The investigations show a general loss in ductility compared to the virgin polyamide 12. A comparison of the different titanium dioxide contents shows no clear change in the flexural stress at conventional bending. The flexural strain at break seems to decrease for higher titanium dioxide contents.
Properties degradation of 3D printed insulators in maritime and indoor environments
Authors: Kuzmanić I. , Vujović I. , Petković M. , Šoda J. 
Published: May 2024

AbstractWith the advances in additive manufacturing, there is the idea of using 3D printers to produce spare parts in isolated systems such as ships, oceangoing vessels, warships, spacecraft, isolated stations, and so on. However, it raises the question of the reliability of such spare parts. One area that has not been explored much is the aging of electrical and dielectric properties, which could reveal weaknesses of 3D‐printed spare parts for use in electrical and automation systems. Therefore, the paper aims to investigate the change in resistance and dielectric constant. The results show that these changes could increase the probability of discharge and have serious consequences for electrical and automation systems.
Reverse engineering of geometric design parameters using shape information of non‐standard spur gear
Authors: Kim S.‐Y. , Jun Y.‐D. , Park S.‐Y. , Go B.‐C. 
Published: May 2024

AbstractIn this study, we conducted research on a method to reverse engineer geometric design parameters from the shape information of gears. The module and normal pressure angle were tracked using the bisection method, and the profile shift coefficient was extracted from the relationship between the working pitch circle diameter, center distance modification coefficient, and working pressure angle. It was confirmed that there are limitations to reverse engineering the shape using only a coordinate measuring machine or 3D scanner because various geometric information is additionally required to trace back the design requirements for gear strength. Finally, the gear tooth bending strength was calculated using finite element analysis and theoretical formula, and through this, the required level of gear strength design was inferred, and the verification of the gear reverse engineering method presented in this study was attempted.
Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands
Authors: Giorgioni Gianfabio , Bonifazi Alessandro , Botticelli Luca , Cifani Carlo , Matteucci Federica , Micioni Di Bonaventura Emanuela , Micioni Di Bonaventura Maria Vittoria , Giannella Mario , Piergentili Alessandro , Piergentili Alessia , Quaglia Wilma , Del Bello Fabio 
Published: May 2024

Abstract5‐HT1A receptor (5‐HT1A‐R) is a serotoninergic G‐protein coupled receptor subtype which contributes to several physiological processes in both central nervous system and periphery. Despite being the first 5‐HT‐R identified, cloned and studied, it still represents a very attractive target in drug discovery and continues to be the focus of a myriad of drug discovery campaigns due to its involvement in numerous neuropsychiatric disorders. The structure‐activity relationship studies (SAR) performed over the last years have been devoted to three main goals: (i) design and synthesis of 5‐HT1A‐R selective/preferential ligands; (ii) identification of 5‐HT1A‐R biased agonists, differentiating pre‐ versus post‐synaptic agonism and signaling cellular mechanisms; (iii) development of multitarget compounds endowed with well‐defined poly‐pharmacological profiles targeting 5‐HT1A‐R along with other serotonin receptors, serotonin transporter (SERT), D2‐like receptors and/or enzymes, such as acetylcholinesterase and phosphodiesterase, as a promising strategy for the management of complex psychiatric and neurodegenerative disorders. In this review, medicinal chemistry aspects of ligands acting as selective/preferential or multitarget 5‐HT1A‐R agonists and antagonists belonging to different chemotypes and developed in the last 7 years (2017–2023) have been discussed. The development of chemical and pharmacological 5‐HT1A‐R tools for molecular imaging have also been described. Finally, the pharmacological interest of 5‐HT1A‐R and the therapeutic potential of ligands targeting this receptor have been considered.
Counter‐intuitive discovery in the formulation of poorly water‐soluble drugs: Amorphous small‐molecule gels
Authors: Shu Yecheng , Zhao Peixu , Li Xin , Shi Xianbao , Fu Qiang 
Published: May 2024

AbstractAmorphous strategies have been extensively used in improving the dissolution of insoluble drugs for decades due to their high free energy. However, the formation of amorphous small‐molecule gels (ASMGs) presents a counter‐intuitive discovery that significantly limits their practical application. Recently, ASMGs have garnered attention because of their noncovalent structures, excellent biodegradability, and significant potential in various drug delivery systems in the pharmaceutical field. Hence, a comprehensive review is necessary to contribute to a better understanding of recent advances in ASMGs. This review aimed to introduce the main formation mechanisms, summarize possible influencing factors, generalize unique properties, outline elimination strategies, and discuss clinical application potential with preclinical cases of ASMGs. Moreover, few ASMGs are advanced to clinical stages. Intensive clinical research is needed for further development. We hope that this review can provide more efficient and rational guidance for exploring further clinical applications of ASMGs.
Almond gum‐chitosan nanocomposite as edible formulation for advancing postharvest longevity of fruits and vegetables
Authors: Suresh Siva Nandhini , SenthilKumar Praveetha , Pushparaj Charumathi , Sarangi Prakash Kumar , Regina Viduthalai Rasheedkhan , Subramani Ramesh 
Published: May 2024

AbstractPostharvest produces including fruits and vegetables are perishable and require preservation for prolonged shelf life. Edible coatings are emerging as a safe and value‐added alternative for traditional preservation methods such as refrigeration and chemical treatments. In this article, we have developed almond gum/chitosan (AC)‐based edible coating/formulation and investigated the effectiveness of coating on improving the shelf life of tomatoes and blueberries. The coated tomatoes and blueberries, after a shelf life of 25 and 20 days, respectively exhibited a significant improvement in weight loss (5%–20%), reduced acidity (1–3 folds), and kept the ascorbic acid content lower when compared to the uncoated tomatoes and blueberries. Both the coated tomatoes and blueberries did not exhibit spoilage indicating antimicrobial activity of the coating. Direct testing of the coating formulations exhibited significant anti‐microbial activity against Staphyococcus aureus and Pseudomonas aeroginosa. The polymer films, prepared using the coating formulation, exhibited low moisture content (34.8 ± 2.02% and 41.5 ± 1.34%), low solubility (42.56 ± 2.3% and 31.31 ± 3.1%), low tensile strength (0.34 ± 0.05 N m−2 and 0.75 ± 0.07 N m−2) and high elongation (63.2 ± 4.12% and 71.5 ± 3.8%). These measured film properties confirm that the polymer film has good flexibility and is suitable for edible packaging. Overall, the newly developed AC edible coating exhibits significant potential for a wide range of applications within the food processing industry, offering a viable substitute for conventional wax and lipid‐based coatings.
Sustained increase in annual transcranial Doppler screening rates in children with sickle cell disease: A quality improvement project
Authors: Edwards Jeffrey G. , Yan Adam P. , Yim Ramy , Oni Mo , Heeney Matthew M. , Johnson Dave , Wong Chris I. , Ilowite Maya , Archer Natasha M. 
Published: May 2024

AbstractIntroductionIndividuals with sickle cell disease (SCD) at increased risk for stroke should undergo annual stroke risk assessment using transcranial Doppler (TCD) screening between the ages of 2 and 16. Though this screening can significantly reduce morbidity associated with SCD, screening rates at Boston Children's Hospital (and nationwide) remain below the recommended 100% screening adherence rates.MethodsThree plan–do–study–act (PDSA) cycles were designed and implemented. The Specific, Measurable, Achievable, Relevant, and Time‐Bound (SMART) aim of our quality improvement (QI) initiative was to sustainably increase the proportion of eligible patients receiving a TCD within 15 months of their last TCD to greater than 95%. An interrupted time series (ITS) analysis was performed, comparing TCD adherence rates from PDSA Cycle 1 to those from PDSA Cycles 2 and 3.ResultsMean TCD adherence increased across all three PDSA cycles, from a baseline of 67% in the first cycle (January 2015 to September 2020) to 92% in the third cycle (May 2021 to March 2023). In the ITS analysis of TCD adherence rates, there was a significant difference in the final TCD adherence rate achieved compared to the rate predicted, with a total estimated increase in adherence of 17.9% being attributable to the interventions from PDSA Cycles 2 and 3.DiscussionAlthough other QI initiatives had demonstrated ability to increase adherence to TCD screening for patients with SCD, this is the first QI project to collect data over such a prolonged period of time to demonstrate a sustained increase in screening rates throughout the intervention (an 8‐year period).
Current surgical approaches to pediatric renal tumors
Authors: Glick Richard D. , Romao Rodrigo L. P. , Pachl Max , Kotagal Meera , Buchanan Amanda F. , Murphy Andrew J. , Tracy Elisabeth T. , Pio Luca , Cost Nicholas G. , Godzinski Jan , Ehrlich Peter F. 
Published: May 2024

AbstractPediatric renal tumors are among the most common pediatric solid malignancies. Surgical resection is a key component in the multidisciplinary therapy for children with kidney tumors. Therefore, it is imperative that surgeons caring for children with renal tumors fully understand the current standards of care in order to provide appropriate surgical expertise within this multimodal framework. Fortunately, the last 60 years of international, multidisciplinary pediatric cancer cooperative group studies have enabled high rates of cure for these patients. This review will highlight the international surgical approaches to pediatric patients with kidney cancer to help surgeons understand the key differences and similarities between the European (International Society of Pediatric Oncology) and North American (Children's Oncology Group) recommendations.
Synthesis and properties of transparent PMMA/cellulose nanocomposites prepared by in situ polymerization in green solvent
Authors: Sušac Kristina , Vidović Elvira , Vrsaljko Domagoj , Jukić Ante 
Published: May 2024

AbstractIn order to contribute to the demanded sustainability transparent poly(methyl methacrylate) (PMMA) composites with cellulose nanocrystals (CNC) up to high shares of 50 wt% were prepared by in situ radical polymerization in green solvent Cyrene. The weight average molecular weights of PMMA were in the range from 144,000 to 160,000 g mol−1 and the dispersity was in the range of 1.49 to 1.89 with high conversion of monomer to polymer. The DSC thermal analysis showed that the glass transition temperature of pure PMMA was at 99°C while in composites increased from 103°C up to 129°C with the increase of CNC from 1 wt% to 50 wt%. TGA shows that the addition of CNC does not have a significant effect on the thermal stability of PMMA. In composites Young's modulus increases with the increasing CNC ratio and composites with 50 wt% of CNC showed more than twice the modulus of the PMMA matrix. The SEM images indicate uniform distribution of CNC in polymer matrix. The transparent and semitransparent PMMA/cellulose composites of improved sustainability with higher modulus of elasticity and glass transition temperature can be used as lightweight materials for a wide range of technical and everyday applications as well as optical lenses or acoustic lenses for ultrasound transducers and other devices.Highlights
Cellulose nanocrystals/PMMA composites fabricated by a green in situ process.
Synthesized PMMA matrices have high molecular weights.
Improved elastic modulus and glass transition temperature were achieved.
Prioritizing eco‐friendly chemicals for a greener production approach.
High strength and high damping CFRP composites with co‐curing viscoelastic sandwich film
Authors: Zheng Changsheng , Zhou Yuesong , Yan Shengyu , Duan Fenghai 
Published: May 2024

AbstractThe high temperature co‐curing damping composite was investigated by co‐curing technology to improve the mechanical property and damping performance of the traditional fiber reinforced resin matrix composite. Fluororubber with stable chemical properties and high‐temperature resistance was used as the core layer of novel carbon fiber reinforced bismaleimide resin matrix High‐temperature Co‐curing Damping Sandwich Composites (HCDSC). The curing temperature and curing time of fluororubber were consistent with that of bismaleimide resin by adjusting the formula. The viscoelastic damping properties and thermal stability of zinc methacrylate reinforced fluororubber were investigated in detail. Static mechanical tests, modal tests and interfacial shear tests prove that HCDSC display excellent mechanical and damping properties. The interfacial microscopic analysis reveals that viscoelastic sandwich materials are closely bonded with the composites. The dynamic characteristics of damping sandwich composite plate with fixed support on four sides is analyzed theoretically, and the vibration equilibrium equation of composite plate is derived by combining first‐order shear deformation theory, variational principle, and Hamilton principle. The damping performance of the composite plate are discussed through modal tests to verify the accuracy of theoretical derivation. This research is of great significance to solve the problem of structural dynamics, and provides a new idea for the design of structural and functional composite materials.Highlights
A viscoelastic damping material with large damping and high strength was prepared.
The dynamic performance of co‐curing sandwich composite structures was studied.
The free vibration of composite structures was explored via experiment and theory.
Construction of 3D nanostructures on carbon fiber surfaces by sizing for preparing high‐performance composites
Authors: Li Weiwen , Quan Guipeng , Li Xumin , Wu Yunhuan , Feng Hengyu , Li Jun , Gong Bao , Ao Yuhui , Xiao Linghan , Liu Yujing 
Published: May 2024

AbstractPoor interfacial adhesion between carbon fibers (CF) and the resin matrix has been a limiting factor in advancing the properties of composites. To address this challenge, this study employs the sizing method to coat carbon nanotubes (CNTs) and hexagonal boron nitride nanosheets (h‐BN) onto the CF surface. The 3D structures formed by strategic of combination 1D and 2D nanomaterials, markedly enhances the mechanical, thermal and frictional properties of CF composites. The results reveal a significant boost in the flexural strength, flexural modulus, interlaminar shear strength and interfacial shear strength of the prepared CF composites, registering increases of 53.96%, 60.41%, 55.58% and 55.35%, respectively. These advancements stem from the heightened surface reactivity and roughness of the fibers, facilitated by the synergistic interactions between CNTs and BN. Furthermore, the thermal conductivity of the composites exhibits a remarkable increase of 63.56%, attributed to the synergistic coupling between CF and BN, establishing an efficient thermal conductivity pathway within the composites. This research provides a highly effective approach for crafting high‐performance CF composites.Highlights
Construction of 3D network structures on CF surfaces by the sizing method.
Synergistic coupling between BN and CNT enhances composite properties.
Synergistic enhancement of friction and thermal properties of CF composites.
Effects of sisal fiber and fly ash on the mechanical and tribological performances of brake friction composites
Authors: Wang Nan , Yin Zixin , Liu Hao , Guo Huanyin 
Published: May 2024

AbstractIndustrial development has led to an increase in demand for friction materials, resulting in increasingly prominent environmental issues throughout their entire life cycle, and developing green and eco‐friendly brake friction materials has become a focus in the braking field. This paper explores the mechanical and tribological properties of fly ash (industrial waste) and sisal fiber (natural fiber) as eco‐friendly components to enhance brake friction materials. Four samples containing different ratios of fly ash and sisal fiber were prepared and tested with a variable‐speed friction testing machine. The results show that the eco‐friendly alternative combination can effectively improve the friction coefficient, and reduce friction fluctuations and thermal degradation, but the wear rate will also increase accordingly. In addition, the worn morphology reveals the formation of the contact platform and wear mechanism. A hybrid integration of analytic hierarchy process (AHP) and multi‐objective optimization by ratio analysis (MOORA) was used to weigh various evaluation indicators objectively and rank the samples. The sample with 8% fly ash and 6% sisal fiber exhibited the best comprehensive tribological performance.Highlights
Development of eco‐friendly brake friction composites with natural and waste additives.
Investigation of the effect of the natural wastes' ratio on prepared composites' physical, mechanical, and tribological properties.
Evaluation of brake friction composites with AHP‐MOORA.
Sample S6F8 exhibits the best comprehensive tribological performance.