bluuebunny/crossref_metadata_2025_split huggingface dataset:
ML1419c Peptide Immunization InducesMycobacterium leprae-Specific HLA-A*0201–Restricted CTL In Vivo with Potential To Kill Live Mycobacteria
Authors: Geluk Annemieke , van den Eeden Susan J. F. , Dijkman Karin , Wilson Louis , Kim Hee Jin , Franken Kees L. M. C. , Spencer John S. , Pessolani Maria C. V. , Pereira Geraldo M. B. , Ottenhoff Tom H. M. 
Published: June 2011

AbstractMHC class I-restricted CD8+ T cells play an important role in protective immunity against mycobacteria. Previously, we showed that p113-121, derived from Mycobacterium leprae protein ML1419c, induced significant IFN-γ production by CD8+ T cells in 90% of paucibacillary leprosy patients and in 80% of multibacillary patients’ contacts, demonstrating induction of M. leprae-specific CD8+ T cell immunity. In this work, we studied the in vivo role and functional profile of ML1419c p113-121–induced T cells in HLA-A*0201 transgenic mice. Immunization with 9mer or 30mer covering the p113-121 sequence combined with TLR9 agonist CpG induced HLA-A*0201–restricted, M. leprae-specific CD8+ T cells as visualized by p113-121/HLA-A*0201 tetramers. Most CD8+ T cells produced IFN-γ, but distinct IFN-γ+/TNF-α+ populations were detected simultaneously with significant secretion of CXCL10/IFN-γ—induced protein 10, CXCL9/MIG, and VEGF. Strikingly, peptide immunization also induced high ML1419c-specific IgG levels, strongly suggesting that peptide-specific CD8+ T cells provide help to B cells in vivo, as CD4+ T cells were undetectable. An additional important characteristic of p113-121–specific CD8+ T cells was their capacity for in vivo killing of p113-121–labeled, HLA-A*0201+ splenocytes. The cytotoxic function of p113-121/HLA-A*0201–specific CD8+ T cells extended into direct killing of splenocytes infected with live Mycobacterium smegmatis expressing ML1419c: both 9mer and 30mer induced CD8+ T cells that reduced the number of ML1419c-expressing mycobacteria by 95%, whereas no reduction occurred using wild-type M. smegmatis. These data, combined with previous observations in Brazilian cohorts, show that ML1419c p113-121 induces potent CD8+ T cells that provide protective immunity against M. leprae and B cell help for induction of specific IgG, suggesting its potential use in diagnostics and as a subunit (vaccine) for M. leprae infection.
Effectiveness of Cognitive–Functional (Cog–Fun) Intervention With Children With Attention Deficit Hyperactivity Disorder: A Pilot Study
Authors: Hahn-Markowitz Jeri , Manor Iris , Maeir Adina 
Published: June 2011

Abstract
The executive function (EF) deficits of children with attention deficit hyperactivity disorder (ADHD) hinder their performance of complex daily functions. Despite the existing evidence-based pharmacological interventions for ADHD symptoms, no intervention has yet been found that deals directly with EFs in daily tasks. Fourteen children and their parents participated in the Cognitive–Functional (Cog–Fun) program in occupational therapy, which is tailored to the executive dysfunction of ADHD and focuses on enabling cognitive strategies for occupational performance. The study included initial assessment of EFs (Behavior Rating Inventory of Executive Functions; Tower of LondonDX), occupational performance (Canadian Occupational Performance Measure), 10 sessions of Cog–Fun intervention with each child–parent dyad, and postintervention and 3-month follow-up assessments. We found significant improvements with medium to large effects on outcome measures after intervention, and most effects were maintained at follow-up. The findings warrant controlled studies examining the effectiveness of this intervention for children with ADHD.
Use of Job-Specific Functional Capacity Evaluation to Predict the Return to Work of Patients With a Distal Radius Fracture
Authors: Cheng Andy S. K. , Cheng Stella W. C. 
Published: June 2011

Abstract
OBJECTIVE. We examined the predictive validity of a job-specific functional capacity evaluation (FCE) in relation to the return to work of patients with a distal radius fracture.
METHOD. Return-to-work recommendations for 194 participants with a distal radius fracture were based on FCE performance. Three months after the evaluation, participants were contacted to ascertain their employment status to examine the predictive validity of each FCE-based rating.
RESULTS. The recommendation return to previous job (94.83%) was correct more often than the recommendations do not work at the moment (60.47%), change job (52.63%), and return to previous job with modifications (9.38%). A longer period from injury to FCE and compensable injury reduces the predictive ability of job-specific FCE.
CONCLUSION. Job-specific FCE shows a better predictive validity in relation to the return to work of patients with a specific injury, such as a distal radius fracture, than of patients with a nonspecific injury.
Participation in Occupation and Diabetes Self-Management in Emerging Adulthood
Authors: Pyatak Elizabeth 
Published: June 2011

Abstract
I present the findings of a study aimed at developing an in-depth understanding of how engagement in occupation influences young adults’ ability to effectively manage diabetes and, conversely, how their diabetes self-management strategies shape their occupational participation. The qualitative interview-based study of 8 people ages 19–25 with Type 1 diabetes revealed that study participants often experienced tension between diabetes self-management and participation in valued occupations, which required them to make calculated decisions about how to balance these competing priorities in their everyday lives. Seven themes are discussed in detail that characterized the relationship between participating in valued occupations and attending to the complex factors that dictate successful diabetes self-management. This research offers a preliminary framework for occupational therapists to assist young adults with diabetes and other chronic illnesses in reconciling these competing demands.
Electroencephalography in Children With and Without Sensory Processing Disorders During Auditory Perception
Authors: Gavin William J. , Dotseth Alycia , Roush Kaylea K. , Smith Courtney A. , Spain Hayley D. , Davies Patricia L. 
Published: June 2011

Abstract
OBJECTIVE. We sought to determine whether children with sensory processing disorder (SPD) differ from typically developing children on a neurophysiological measure, the P300 component of event-related potentials produced in response to brief auditory stimulation.
METHOD. We used electroencephalographic measures (i.e., N200 and P300 components) to examine auditory processing in 20 children with SPD and 71 typically developing children, ages 5–10 yr.
RESULTS. Children with SPD demonstrated significantly smaller P300 amplitudes and shorter N200 latencies than typically developing children. Brain activity correctly distinguished children with SPD from typically developing children with 77% accuracy. We also found a significant relationship between the neurophysiological measures and functional performance on sensory and motor tasks.
CONCLUSION. This study presents empirical evidence that children with SPD display unique brain processing mechanisms compared with typical children and, therefore, provide further evidence for the neural deviations associated with SPD.
Occupational Therapy Interventions for Chronic Diseases: A Scoping Review
Authors: Hand Carri , Law Mary , McColl Mary Ann 
Published: June 2011

Abstract
OBJECTIVE. We reviewed the evidence regarding the effectiveness of community occupational therapy interventions, delivered alone or within a multidisciplinary team, in improving occupational outcomes for adults with selected chronic diseases.
METHOD. We completed a scoping review of randomized controlled trials published from 1988 through 2008. Studies included participants with heart disease, depression, rheumatoid arthritis, osteoarthritis, chronic obstructive pulmonary disorder, or diabetes.
RESULTS. Sixteen studies met the inclusion criteria. Ten studies found significant differences between intervention and control groups for at least one outcome of function in activities of daily living, functional self-efficacy, social or work function, psychological health, general health, or quality of life. Conflicting evidence exists regarding the impact of intervention on physical function and health.
CONCLUSION. Occupational therapy can improve occupational outcomes in adults with chronic diseases. Using and building on this evidence, occupational therapists can continue to promote their role in helping to meet this population's needs.
Multilevel text mining for bone biology
Authors: Tilak Omkar , Hoblitzell Andrew , Mukhopadhyay Snehasis , You Qian , Fang Shiaofen , Xia Yuni , Bidwell Joseph 
Published: June 2011

SUMMARYOsteoporosis is characterized by reduced bone mass and debilitating fractures and is likely to reach epidemic proportions. Because of the vigorous research taking place in fields related to osteoporosis, bone biologists are overwhelmed by the amount of literature being generated on a regular basis. This problem can be alleviated by inferring and extracting novel relationships among biological entities appearing in the biological literature. With the development of large online publicly available databases of biological literature, such an approach becomes even more appealing. The novel relationships between biological terms thus discovered constitute new hypotheses that can be verified using experiments. This paper presents a novel method called multilevel text mining for the extraction of potentially meaningful biological relationships. Multilevel mining uses transitive maximum flow graph analysis coupled with set combination operations of union and intersection. Set operators are applied along and across the paths of a transitive flow graph to combine the data. In the first level of the multilevel mining process, protein domain names are used. Novel relationships between domains are extracted by the transitive text mining analysis. In the second level, these newly discovered relationships are used to extract relevant protein names. Set operators are used in various combinations to obtain different sets of results. Copyright © 2011 John Wiley & Sons, Ltd.
Irreducibility and emergence in complex systems and the quest for alternative insights
Authors: Hosseinie Radmarz , Mahzoon Mojtaba 
Published: June 2011

AbstractThe scientist does not study nature because it is useful; he studies it because he delights in it, and he delights in it because it is beautiful.Henri PoincaréIn this essay, we briefly survey the contemporary scientific and philosophical debates on emergence and conclude that this notion has become a dilemma. We argue that the reason for this dilemma is metaphysical. Subsequently, we investigate some fundamental philosophical methods in science, such as Cartesian reduction and objectivism, as the main sources of scientific drawbacks. Eventually, we suggest some refinements in philosophical methods for improvement of scientific insight and propose the method of transcendentionism as a metaphysical panacea to encounter the dilemma of emergence. © 2011 Wiley Periodicals, Inc. Complexity, 17,10–18, 2011
New numerical techniques for bifurcation analysis of power systems with application to grid‐connected voltage source converter
Authors: Cole Stijn , Srivastava Kailash , Reza Muhamad , Belmans Ronnie 
Published: June 2011

SUMMARYIn many papers, in dealing with bifurcation analysis of power systems, the power system is modelled as an ordinary differential equation system, in order to conveniently use the theory and numerical tools developed for bifurcation analysis of ordinary differential equation systems. We explain in this work how state‐of‐the‐art numerical techniques for bifurcation analysis, not well known in the power system community, can be extended to the more conventional power system model, that is a differential algebraic equation system, including power system specifics such as limits. Bordered matrices are extensively used, notably for the detection and exact localisation of singular points, as well as their continuation in two‐parameter continuation. The methods are tested on a simple power system with grid‐connected voltage source converter. Copyright © 2011 John Wiley & Sons, Ltd.
Spectroscopic detection of β ‐sheet structure in nascent Aβ oligomers
Authors: Wang Mingjuan , JiJi Renee D. 
Published: June 2011

AbstractDeep‐UV resonance Raman (UVRR) spectroscopy and circular dichroism (CD) were employed to study the secondary structure of Aβ(1–42) in fresh samples with increasing fractions of oligomeric peptide. A feature with a minimum at ∼217 nm appeared in CD spectra of samples containing oligomeric Aβ(1–42). UVRR spectra more closely resembled those of disordered proteins. The primary difference between UVRR spectra was the ratio of the 1236 cm–1 to 1260 cm–1 amide III peak intensities, which shifted in favor of the 1236 cm–1 band as the fraction of oligomeric peptide increased. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Nonlinear registration of diffusion‐weighted images improves clinical sensitivity of functional diffusion maps in recurrent glioblastoma treated with bevacizumab
Authors: Ellingson Benjamin M. , Cloughesy Timothy F. , Lai Albert , Nghiemphu Phioanh L. , Pope Whitney B. 
Published: June 2011

AbstractDiffusion‐weighted imaging estimates of apparent diffusion coefficient (ADC) have shown sensitivity to brain tumor cellularity as well as response to therapy. Functional diffusion maps (fDMs) exploit these principles by examining voxelwise changes in ADC within the same patient over time. Currently, the fDM technique involves linear image registration of ADC maps from subsequent follow‐up times to pretreatment ADC maps; however, misregistration of ADC maps due to geometric distortions as well as mass effect from growing tumor can confound fDM measurements. In this study, we compare the use of a nonlinear registration scheme to the current linear fDM technique in 70 patients with recurrent glioblastoma multiforme treated with bevacizumab. Results suggest that nonlinear registration of pretreatment ADC maps to post‐treatment ADC maps improves the clinical predictability, sensitivity, and specificity of fDMs for both progression‐free and overall survival. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.
Reconstruction of fully three‐dimensional high spatial and temporal resolution MR temperature maps for retrospective applications
Authors: Todd Nick , Vyas Urvi , de Bever Josh , Payne Allison , Parker Dennis L. 
Published: June 2011

AbstractMany areas of MR‐guided thermal therapy research would benefit from temperature maps with high spatial and temporal resolution that cover a large three‐dimensional volume. This article describes an approach to achieve these goals, which is suitable for research applications where retrospective reconstruction of the temperature maps is acceptable. The method acquires undersampled data from a modified three‐dimensional segmented echo‐planar imaging sequence and creates images using a temporally constrained reconstruction algorithm. The three‐dimensional images can be zero‐filled to arbitrarily small voxel spacing in all directions and then converted into temperature maps using the standard proton resonance frequency shift technique. During high intensity focused ultrasound heating experiments, the proposed method was used to obtain temperature maps with 1.5 mm × 1.5 mm × 3.0 mm resolution, 288 mm × 162 mm × 78 mm field of view, and 1.7 s temporal resolution. The approach is validated to demonstrate that it can accurately capture the spatial characteristics and time dynamics of rapidly changing high intensity focused ultrasound‐induced temperature distributions. Example applications from MR‐guided high intensity focused ultrasound research are shown to demonstrate the benefits of the large coverage fully three‐dimensional temperature maps, including characterization of volumetric heating trajectories and near‐ and far‐field heating. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc.
Profiling mass affluent luxury goods consumers in China: A psychographic approach
Authors: Xiao Lu Pierre , Pras Bernard 
Published: June 2011

AbstractThis article focuses on the main group of luxury goods consumers in China, the Chinese elite, who are of critical importance for marketing luxury goods. First, after defining the Chinese elite, we identify the relevant dimensions to segment this mass affluent group: conspicuous/functional, individualist/collectivist, impulsive/rational, and propensity to innovate. Second, we show the emergence of four clusters along these psychographic dimensions but also sociodemographic and geographic characteristics: luxury lovers, luxury followers, luxury intellectuals, and luxury laggards. Third, we present examples of consumers' profiles in each cluster and illustrate these examples with excerpts from in‐depth interviews. Finally, we show how this approach can help managers to identify Chinese elite luxury segments and efficiently target them. We propose segmented or crossover marketing strategies and conclude with recommendations for a better understanding of innovativeness, enhancing brand loyalty, and reducing postpurchase guilt, with respect to these segments. © 2011 Wiley Periodicals, Inc.
The entry‐mode decision of Chinese outward FDI: Firm resources, industry conditions, and institutional forces
Authors: Cui Lin , Jiang Fuming , Stening Bruce 
Published: June 2011

AbstractHow do Chinese firms make their entry‐mode decision for their outward investments? Based on the three theoretical perspectives that balance the “strategy tripod,” our study conducted empirical tests using survey data collected from outward‐investing Chinese firms. We found that the cost advantage of the investing firm and learning opportunities in the host industry have positive effects on the likelihood of a Chinese firm opting for wholly owned subsidiary against joint‐venture entry mode, while the market attractiveness of the host industry, host‐country restrictions, cultural barriers, and cognitive pressures have negative effects. © 2011 Wiley Periodicals, Inc.
Bisphenol A and estrone‐induced developmental effects in early chick embryos
Authors: Saito Kenichi , Niijima Azusa , Kamite Eri , Watanabe Mari 
Published: June 2011

AbstractEndocrine disruptors, especially estrogenic substances, are thought to affect the reproduction and development of animals, including humans. We therefore assessed whether bisphenol A (BPA) or estrone (E1) had any adverse effects on chick embryogenesis. Fertilized eggs of white Leghorns were obtained within 24 h after laying. Embryos were administered 0.1, 1.0, and 10.0 mM BPA, and administered 10, 100 nM, and 1 μM E1, and incubated for 48 h at 37 ± 0.5°C and >80% relative humidity with one rotation per hour. The embryos were excised, fixed in 70% ethanol and viewed under a stereomicroscope. Their morphological abnormalities and numbers of somites were recorded. There were no significant difference in the average number of somites in embryos administered BPA and controls. Abnormal embryogenesis, however, showed dose‐related increases caused by BPA and E1. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2012.
Correlation diagram approach as a tool for interpreting chemistry: an introductory overview
Authors: Hirao Hajime 
Published: June 2011

AbstractIn the frameworks of both molecular orbital (MO) and valence bond (VB) theories, the correlation diagram approach aids understanding of a wide range of chemical phenomena. MO‐based correlation diagrams are based upon one‐electron MOs or electronic configuration functions and have been broadly applied to both thermal and photochemical reactions. VB‐based correlation diagrams utilize VB structures to express diabatic states and are especially powerful in analyzing chemical bonding and chemical reactivity. These approaches help us to understand the electronic behavior of molecules and fill the gap between intricate wave functions and the chemists' viewpoint. This paper provides an introductory overview of the correlation diagram approach, with a greater emphasis placed on VB state correlation diagrams. © 2011 John Wiley & Sons, Ltd. WIREs Comput Mol Sci 2011 1 337–349 DOI: 10.1002/wcms.20This article is categorized under:

Structure and Mechanism > Molecular Structures
Rotational barriers in alkanes
Authors: Mo Yirong 
Published: June 2011

AbstractRotational barriers in alkanes play a fundamental role in the stereochemistry and dynamics of alkanes and others such as proteins. Yet, the proper understanding of their origin which is central to chemical theory remains controversial. Currently, there are two major competing models to interpret the barriers, one is the steric repulsion model and the other is hyperconjugation model. No consensus has been reached. It is thus important to critically examine the quantum mechanical approaches producing conflicting data which lead to these models, as various approximations must be introduced to derive either the steric or hyperconjugative interaction energies in these approaches. The hyperconjugation model is largely based on the popular natural bond orbital (NBO) analysis which can estimate individual interactions between occupied bond orbitals and vicinal unoccupied antibond orbitals. But the concern is that these localized bond orbitals are projected out from a delocalized wavefunction and thus nonoptimal. Alternatively, recent studies with other methods notably the ab initio valence bond theory where localized orbitals are self‐consistently optimized reinstate the conventional steric repulsion model, although the NBO method correctly predicts that there is stronger hyperconjugative interaction in staggered structures than in eclipsed structures. After all, it is the steric effect rather than the hyperconjugation effect that plays a dominating role in rotational barriers in alkanes. © 2011 John Wiley & Sons, Ltd. WIREs Comput Mol Sci 2011 1 164‐171 DOI: 10.1002/wcms.22This article is categorized under:

Structure and Mechanism > Computational Materials Science
Quantum Monte Carlo methods
Authors: Lüchow Arne 
Published: June 2011

AbstractSimulations of complex systems have seen rapid progress over the last decade not only due to the continuous acceleration of computer resources but also due to improvements of methods and algorithms. Simulations complement experiments and model calculations in the effort to get insight into complex systems such as materials, complex liquids, or complicated molecules. As such, computer simulations are a strongly interdisciplinary field where chemistry meets physics, biology, and material science. Most simulations are based on classical physics because the interaction between atoms or even larger entities can be modeled accurately with classical mechanics for most problems as long as no chemical reactions are involved. If the interaction between atoms in a molecule or between molecules is to be calculated, for instance, to obtain parameters for modeling the interactions in classical simulations, classical physics has to be abandoned because these interactions involve the electron distributions which require a quantum mechanical description. © 2011 John Wiley & Sons, Ltd. WIREs Comput Mol Sci 2011 1 388–402 DOI: 10.1002/wcms.40This article is categorized under:Electronic Structure Theory > Ab Initio Electronic Structure Methods
Gn theory
Authors: Curtiss Larry A. , Redfern Paul C. , Raghavachari Krishnan 
Published: June 2011

AbstractA review of the Gaussian‐n (Gn) methods for accurate calculations of molecular energies is presented. The review includes an overview of the test sets that have been developed for assessing quantum chemical methods. This is followed by a description of the G2, G3, and G4 family of methods along with information on their performance on the test sets. © 2011 John Wiley & Sons, Ltd. WIREs Comput Mol Sci 2011 1 810–825 DOI: 10.1002/wcms.59This article is categorized under:

Electronic Structure Theory > Ab Initio Electronic Structure Methods