bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of magnetic core‐mesoporous shell microspheres with C8‐modified interior pore‐walls and their application in selective enrichment and analysis of mouse brain peptidome
Authors: Liu Shasha , Li Yan , Deng Chunhui , Mao Yu , Zhang Xiangmin , Yang Pengyuan 
Published: September 2011

AbstractIn this paper, magnetic mesoporous silica microspheres with C8‐modified interior pore‐walls were prepared through a facile one‐pot sol–gel coating strategy, and were successfully applied for selective enrichment of endogenous peptides in mouse brain for peptidome analysis. Through the one‐pot sol–gel approach with surfactant (CTAB) as a template, tetraethyl orthosilicate (TEOS) and n‐ctyltriethoxysilane (C8TEOS) as the precursors, C8‐modified magnetic mesoporous microspheres (C8‐Fe3O4@mSiO2) consisting magnetic core and mesoporous silica shell with C8‐groups exposed in the mesopore channels were synthesized. The obtained microspheres possess highly open mesopores of 3.4 nm, high surface area (162.5 m2/g), large pore volume (0.17 cm3/g), excellent magnetic responsivity (56.3 emu/g) and good dispersibility in aqueous solution. Based on the abundant surface silanol groups, functional C8 groups and the strong magnetic responsivity of the core‐shell C8‐Fe3O4@mSiO2 microspheres, efficient and fast enrichment of peptides was achieved. Additionally, the C8‐Fe3O4@mSiO2 microspheres exhibit excellent performance in selective enrichment of endogenous peptides from complex samples that are consist of peptides, large proteins and other compounds, including human serum and mouse brain followed by automated nano‐LC‐ESI‐MS/MS analysis. These results indicate C8‐Fe3O4@mSiO2 microspheres would be a potential candidate for endogenous peptides enrichment and biomarkers discovery in peptidome analysis.
Magnetic poly(N‐propargylacrylamide) microspheres: Preparation by precipitation polymerization and use in model click reactions
Authors: Macková Hana , Proks Vladimír , Horák Daniel , Kučka Jan , Trchová Miroslava 
Published: September 2011

AbstractMagnetic poly(N‐propargylacrylamide) (PPRAAm) microspheres were prepared by the precipitation polymerization of N‐propargylacrylamide (PRAAm) in a toluene/propan‐2‐ol medium in the presence of magnetic nanoparticles (oleic acid‐coated Fe3O4). The effects of several polymerization parameters, including the polarity of the medium, polymerization temperature, the concentration of monomer, and the amount of magnetite (Fe3O4) in the polymerization feed, were examined. The microspheres were characterized in terms of their morphology, size, particle‐size distribution, and iron content using transmission and scanning electron microscopies (TEM and SEM) and atomic absorption spectroscopy (AAS). A medium polarity was identified in which magnetic particles with a narrow size distribution were formed. As expected, oleic acid‐coated Fe3O4 nanoparticles contributed to the stabilization of the polymerized magnetic microspheres. Alkyne groups in magnetic PPRAAm microspheres were detected by infrared spectroscopy. Magnetic PPRAAm microspheres were successfully used as the anchor to enable a “click” reaction with an azido‐end‐functionalized model peptide (radiolabeled azidopentanoyl‐GGGRGDSGGGY(125I)‐NH2) and 4‐azidophenylalanine using a Cu(I)‐catalyzed 1,3‐dipolar azide‐alkyne cycloaddition reaction in water. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.
Synthesis and chemosensing behavior of fluorene‐based alternating copolymers containing ether side chains and Si–vinylene units in the main chain
Authors: Naga Naofumi , Ohkura Yoshikazu , Tagaya Nanae , Tomoda Haruhiko 
Published: September 2011

AbstractAlternating copolymerization of 9,9‐bis(3,6,9‐trioxadecyl)‐2,7‐dibromofluorene (ODFl) or 9,9‐bis(3,6‐dioxaheptyl)‐2,7‐dibromofluorene with Si containing divinyl compounds, divinyldiphenylsilane (VPS), or divinyldimethylsilane (VMS) is investigated using the Mizoroki–Heck reaction with palladium(II) acetate. The corresponding alternating copolymer is obtained in the copolymerization of ODFl with VPS. The copolymerization of ODFl with VMS yields low molecular weight oligomers. Optical properties of the ODFl–VPS copolymer have been investigated with UV–vis absorption and photoluminescence (PL) spectroscopy. The ODFl–VPS copolymer shows absorption peaks due to π–π* transition and intramolecular charge transfer through σ–π moiety at around 330 and 360–400 nm, respectively. An emission peak is observed at 450 nm in the PL spectrum of the ODFl–VPS copolymer, and the PL quantum yield is 0.19. The PL spectroscopy of ODFl–VPS copolymer is investigated in the presence of Li+, Na+, and K+, and the intensity of emission peak is decreased by those metal cations, especially by Na+. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.
Electrospun poly(aniline‐co‐ethyl 3‐aminobenzoate)/poly(lactic acid) nanofibers and their potential in biomedical applications
Authors: Gizdavic‐Nikolaidis Marija , Ray Sudip , Bennett Jared , Swift Simon , Bowmaker Graham , Easteal Allan 
Published: September 2011

AbstractPoly(aniline‐co‐ethyl 3‐aminobenzoate) (3EABPANI) copolymer was blended with poly(lactic acid) (PLA) and co‐electrospun into nanofibers to investigate its potential in biomedical applications. The relationship between electrospinning parameters and fiber diameter has been investigated. The mechanical and electrical properties of electrospun 3EABPANI‐PLA nanofibers were also evaluated. To assess cell morphology and biocompatibility, nanofibrous mats of pure PLA and 3EABPANI‐PLA were deposited on glass substrates and the proliferation of COS‐1 fibroblast cells on the nanofibrous polymer surfaces determined. The nanofibrous 3EABPANI‐PLA blends were easily fabricated by electrospinning and gave enhanced mammalian cell growth, antioxidant and antimicrobial capabilities, and electrical conductivity. These results suggest that 3EABPANI‐PLA nanofibrous blends might provide a novel bioactive conductive material for biomedical applications. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.
Cationation of dimethylallyl alcohols by B(C6F5)3 as models of the (Re)initiation reaction in the bio‐inspired cationic polymerization of isoprene
Authors: Ouardad Samira , Kostjuk Sergei V. , Ganachaud François , Puskas Judit E. , Deffieux Alain , Peruch Frederic 
Published: September 2011

AbstractThe polymerization of isoprene initiated by dimethylallyl alcohols (DMAOH) in the presence of Lewis acids (LAs) as coinitiators has been selected as a potential model of the proposed cationic mechanisms involved in natural rubber (NR) biosynthesis. In view to investigate the activation/ionization mechanism of the allyl alcohol chain terminus (PIAllOH), which was shown to exist in NR, different isomers of DMAOH were used as simple models of polyisoprene chain‐end structures in the presence of tris(pentafluorophenyl)borane (BLA) as a LA. It is shown that cationation of 3,3‐DMAOH by BLA proceeds by direct OH abstraction. However, this process is strongly retarded in the presence of 2,6‐di‐tert‐butylpyridine (dtBP), due to the formation of different BLA complexes, one with 3,3‐DMAOH, active for cationation, and a dormant one involving its ionized form 3,3‐DMAO−. The monomer generated in situ by ionization/proton elimination steps subsequently adds on the primary allylic carbocation form, then resulting in the formation of oligoisoprenes, whereas the tertiary carbocation form of the allylic carbocation yields exclusively to proton elimination and isoprene formation, a possible mechanism of chain‐end termination. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.
Functional, hyperbranched polyesters via baylis–hillman polymerization
Authors: Ji Sanhao , Bruchmann Bernd , Wurm Frederik , Klok Harm‐Anton 
Published: September 2011

AbstractHyperbranched polyesters are among the most common hyperbranched polymers. One of the interesting features of hyperbranched polyesters is that they contain unreacted hydroxyl and carboxylic acid groups at the linear and terminal structural units, which can be postmodified to adjust thermal, solubility, or mechanical properties, or to prepare core–shell type architectures. This article reports on the synthesis of a novel class of hyperbranched polyesters via an A2 + B3 type Baylis–Hillman polymerization of 2,6‐pyridinedicarboxaldehyde and trimethylolpropane triacrylate. Baylis–Hillman polymerization generates highly functional polyesters that contain not only unreacted aldehyde and/or acrylate groups at the linear and terminal structural units but also chemically orthogonal vinyl and hydroxyl groups along the polymer backbone. Using 3‐hydroxyquinuclidine as the catalyst, hyperbranched polymers with number‐average molecular weights up to 7500 g/mol and degrees of branching up to 0.81 were obtained. To demonstrate the versatility of these hyperbranched polyesters to act as platforms for further derivatization, the orthogonal postpolymerization modification of the hydroxyl, vinyl, and pyridine functional moieties with phenyl isocyanate, methyl‐3‐mercaptopropionate, and methyl iodide is presented. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012.
Synthesis, characterization, and properties of poly(ester‐phosphoester)s by lanthanum triphenolate‐catalyzed ring‐opening copolymerization
Authors: Zhu Weipu , Sun Shuai , Xu Ning , Shen Zhiquan 
Published: September 2011

AbstractThe ring‐opening copolymerization of methyl ethylene phosphate (MEP, 2‐methoxy‐2‐oxo‐1,3,2‐dioxaphospholane) and ε‐caprolactone (CL) was performed in bulk with lanthanum tris(2,6‐di‐tert‐butyl‐4‐methylphenolate)s as single‐component catalyst, resulting in poly(ester‐phosphoester) random copolymers with high molecular weight and moderate molecular weight distribution. The properties of the copolymers were characterized by differential scanning calorimetry, X‐ray diffractometer, dynamic mechanical analysis, and static water contact angle measurement. The crystallinities of the copolymers were reduced with the increase of MEP molar fraction in the products. Moreover, copolymers with enhanced hydrophilicity and lower glass transition temperature could be obtained with higher MEP content, which may provide potential applications in biomedical field. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.
Synthesis and isomerization of conjugated oligomers containing azoimidazole unit
Authors: Takagi Koji , Isomura Takato , Ito Yohei , Sakaida Masanori , Nagano Shusaku , Seki Takahiro 
Published: September 2011

AbstractThe Suzuki (for O1–O3) and Stille (for O4) coupling polymerization of 2‐(phenylazo)imidazole bearing the benzyl protecting group at the 1‐position gave conjugated oligomers. The transformation from the neutral imidazole in the conjugated oligomer O2, consisted of the alternating 2,5‐didecyl‐1,4‐phenylene unit, to the cationic imidazolium salt O2S was performed. Depending on the chemical structure of coupling partners, the absorption maximum of conjugated oligomers showed red shift or blue shift from that of the model compound M with the benzene ring at the 4,5‐positions. The absorption maximum wavelength of the cationic conjugated oligomer O2S showed a blue shift from that of the neutral conjugated oligomer O2. The trans‐to‐cis photoisomerization of the azoimidazole unit in conjugated oligomers was observed by irradiating the light at 436 nm, and the conversion degree to the cis structure had a rough correlation with the maximum absorption wavelength of materials. The trans‐to‐cis photoisomerization in the film state was sluggish. On the other hand, the cis‐to‐trans thermal isomerization of the azoimidazole unit was confirmed and the absorbance returned to the initial state before the photoisomerization. The trans‐to‐cis photoisomerization of the cationic conjugated oligomer O2S required large energy, and the prolonged light irradiation might decompose the azoimidazole unit. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011.
Refinement of the Distress Management Problem List as the basis for a holistic therapeutic conversation among UK patients with cancer
Authors: Brennan James , Gingell Polly , Brant Heather , Hollingworth William 
Published: September 2011

AbstractObjectiveOriginally devised in the USA, the Distress Thermometer is being deployed in many cancer settings in the UK. It is commonly used with a Problem List (PL), which has never been validated with a UK population. This study aimed to refine the PL items based upon the concerns of a sample of UK patients attending a regional cancer centre.MethodsExisting versions of the PL were scrutinised by a focus group comprising five ex‐patients, six health care staff and two academics. This group considered the intelligibility, ambiguity and redundancy of items, sometimes making alternative suggestions or pooling items. The resulting 46 candidate items were sent to 735 patients with mixed cancer, asking them to endorse items that had been ‘a source of concern or distress’ during their recently finished treatment. We used multivariate logistic regression to evaluate the association between the prevalence of problems and patient characteristics.ResultsIn this study, 395 (53%) people responded. ‘Fatigue, exhaustion or extreme tiredness’ (70%), ‘worry, fear or anxiety’ (45%) and ‘sleep problems’ (38%) were the most frequently endorsed items. Items not appearing on the original PL were commonly endorsed such as ‘memory or concentration’ (30%) and ‘loneliness or isolation’ (15%), suggesting that they should be routinely included in the Distress Thermometer Problem List.ConclusionsThe current study offers a more comprehensive PL, on the basis of actual patients' concerns, using words that are understood by UK patients. The reluctance of some patients to volunteer their concerns suggests that screening for distress should be undertaken within the context of a structured conversation. Copyright © 2011 John Wiley & Sons, Ltd.
Partners and close family members of long‐term cancer survivors: health status, psychosocial well‐being and unmet supportive care needs
Authors: Turner Daniel , Adams Eike , Boulton Mary , Harrison Sian , Khan Nada , Rose Peter , Ward Alison , Watson Eila K. 
Published: September 2011

AbstractBackgroundA cancer diagnosis can have a profound impact on partners and close family members of patients. Little is currently known about the long‐term impact.ObjectivesThe objective of this study is to describe health status, levels of anxiety and depression, unmet supportive care needs and positive outcomes in the partners/family members of breast, prostate and colorectal cancer survivors 5–16 years post‐diagnosis.MethodsPatients in a linked study were asked to invite a partner or other close family member to complete a self‐administered postal questionnaire. Data were analysed by cancer site and time since diagnosis. Matched comparisons were made between cancer patients in the linked study and their partners.ResultsAn expression of interest was received from 330 partners/family members, and 257 questionnaires (77.9%) were returned. Health status and levels of anxiety and depression were comparable with population norms. Respondents reported an average of 2.7 unmet needs from 34 possible options. Hospital parking, information about familial risk, help managing fear of recurrence and coordination of care were the most cited unmet needs. There was little variation in health status, psychological morbidity and unmet needs by cancer site or time since diagnosis. Concordance between patients and partners was low for anxiety but higher with respect to positive outcomes and some unmet needs.ConclusionsMost partners/family members of long‐term cancer survivors report few ongoing issues. However, a small proportion (<10%) have high levels of anxiety and/or moderate or strong unmet needs. Strategies for identifying this group and addressing their needs are required, while allowing the majority to resume normal life. Copyright © 2011 John Wiley & Sons, Ltd.
Have a little faith: measuring the impact of illness on positive and negative aspects of faith
Authors: Salsman John M. , Garcia Sofia F. , Lai Jin‐Shei , Cella David 
Published: September 2011

AbstractBackgroundThe importance of faith and its associations with health are well documented. As part of the Patient Reported Outcomes Measurement Information System, items tapping positive and negative impact of illness (PII and NII) were developed across four content domains: Coping/Stress Response, Self‐Concept, Social Connection/Isolation, and Meaning and Spirituality. Faith items were included within the concept of meaning and spirituality.MethodsThis measurement model was tested on a heterogeneous group of 509 cancer survivors. To evaluate dimensionality, we applied two bi‐factor models, specifying a general factor (PII or NII) and four local factors: Coping/Stress Response, Self‐Concept, Social Connection/Isolation, and Meaning and Spirituality.ResultsBi‐factor analysis supported sufficient unidimensionality within PII and NII item sets. The unidimensionality of both PII and NII item sets was enhanced by extraction of the faith items from the rest of the questions. Of the 10 faith items, nine demonstrated higher local than general factor loadings (range for local factor loadings = 0.402 to 0.876), suggesting utility as a separate but related ‘faith’ factor. The same was true for only two of the remaining 63 items across the PII and NII item sets.ConclusionsAlthough conceptually and to a degree empirically related to Meaning and Spirituality, Faith appears to be a distinct subdomain of PII and NII, better handled by distinct assessment. A 10‐item measure of the impact of illness upon faith (II‐Faith) was therefore assembled. Copyright © 2011 John Wiley & Sons, Ltd.
Quantitative in vivo solubility and reconstitution of truncated circular permutants of green fluorescent protein
Authors: Huang Yao‐Ming , Nayak Sasmita , Bystroff Christopher 
Published: September 2011

AbstractSeveral versions of split green fluorescent protein (GFP) fold and reconstitute fluorescence, as do many circular permutants, but little is known about the dependence of reconstitution on circular permutation. Explored here is the capacity of GFP to fold and reconstitute fluorescence from various truncated circular permutants, herein called “leave‐one‐outs” using a quantitative in vivo solubility assay and in vivo reconstitution of fluorescence. Twelve leave‐one‐out permutants are discussed, one for each of the 12 secondary structure elements. The results expand the outlook for the use of permuted split GFPs as specific and self‐reporting gene encoded affinity reagents.
Front‐side illuminated dye‐sensitized solar cells based on bundle shaped titania nanotube membranes
Authors: Stergiopoulos T. , Likodimos V. , Hahn R. , Schmuki P. , Falaras P. 
Published: September 2011

AbstractTiO2 nanotubular (NT) membranes with bundle shape morphology were prepared by rapid breakdown anodization (RBA) in fluorine free aqueous electrolytes. The self‐assembled nanotube‐like materials were detached from the metal foil by immersion in methanolic Br2 solution and the free‐standing membranes were successfully transferred on top of transparent conductive electrodes modified by freshly prepared nanoparticulate (NP) titania films. The composite electrodes, after post‐annealing at 450 °C, were crystallized under the anatase polymorphism and, then, effectively sensitized by the standard N719 dye (confirmed by micro‐Raman spectroscopy under Resonance conditions). The resulting photoelectrodes were incorporated in dye‐sensitized solar cells (DSCs) enabling front‐side illumination (FSI). The fabricated DSCs attained overall photovoltaic conversion efficiencies of the order of 4.6% under 1 sun (AM 1.5) illumination. The relatively high performance was mainly attributed to the successful packing of the two (NT and NP) layers creating a low resistance interface as well as to the favourable electron transport/recombination dynamics that govern these solar cells.magnified image
Work Locus of Control and its Relationship to Stress Perception, Related Affections, Attitudes and Behaviours from a Domain‐specific Perspective
Authors: Tong Jiajin , Wang Lei 
Published: September 2011

AbstractThis research aims to examine the value of applying the Work Locus of Control Scale in predicting work‐related outcomes. Study 1 surveyed 323 employees from different companies in China and found that the domain‐specific scale was more predictive than the general scale in predicting perceived stressors, rather than in predicting organizational affective commitment and altruistic behaviour. Study 2 applied a multi‐wave and multi‐source design and used commensurate Likert scales to measure work and general locus of control. Participants were 344 employees from one corporation. Work locus of control was found to be more useful in predicting supervisor‐rated job performance, conscientious and altruistic behaviours. These findings help understand the theory‐based and measurement‐based reasons for the advantages of using domain‐specific measures. They claim the importance for employing the domain‐specific measure to predict work‐related perceptions and behaviours. Implications for the theory and practice are discussed. Copyright © 2011 John Wiley & Sons, Ltd.
Pre‐ and postsynaptic effects of norepinephrine on γ‐aminobutyric acid‐mediated synaptic transmission in layer 2/3 of the rat auditory cortex
Authors: Salgado Humberto , Garcia‐Oscos Francisco , Martinolich Laura , Hall Shawn , Restom Robert , Tseng Kuei Y. , Atzori Marco 
Published: September 2011

AbstractNoradrenergic terminals from the locus coeruleus release norepinephrine (NE) throughout most brain areas, including the auditory cortex, where they affect neural processing by modulating numerous cellular properties including the inhibitory γ‐aminobutyric acid (GABA)ergic transmission. We recently demonstrated that NE affects GABAergic signaling onto cortical pyramidal cells in a complex manner. In this study, we used a combination of patch‐clamp recording and immunohistochemical techniques to identify the synaptic site and the location of the adrenergic receptors involved in the modulation of GABAergic signaling in cortical layer 2/3 of the rat. Our results showed that NE increases the frequency of spike‐independent miniature inhibitory postsynaptic currents (mIPSCs), as well as the probability of release of unitary inhibitory postsynaptic currents (IPSCs) obtained with patch‐clamp pair‐recordings. The pharmacology of mIPSCs and the identification of adrenergic receptors in neurons containing the GABAergic marker parvalbumin (PV) suggest that NE increases the presynaptic probability of GABA release by activating α2‐ and β‐receptors on PV‐positive neurons. On the contrary, bath‐applied NE or phenylephrine, decreased the current mediated by pressure application of the GABAA‐receptor agonist muscimol, as well as the amplitude—but not the frequency—of mIPSCs, indicating that activation of postsynaptic α1 adrenoceptors reversibly depressed GABAergic currents. We speculate that while a generalized postsynaptic decrease of GABAergic inhibition might decrease the synaptic activation threshold for pyramidal neurons corresponding to an alert state, NE might promote perception and sensory binding by facilitating lateral inhibition as well as the production of γ‐oscillations by a selective enhancement of perisomatic inhibition. Synapse, 2012. © 2011 Wiley Periodicals, Inc.