bluuebunny/crossref_metadata_2025_split huggingface dataset:
Theoretical Optimization and Comparison of (FA)2BiCuI6 and Cs2AgBi0.75Sb0.25Br6 Based Double Perovskite Solar Cells
Authors: Rana Ashish D. , Bhargava Kshitij 
Published: February 2025

AbstractTo overcome the issue of toxicity in lead (Pb) based perovskite solar cells, this work investigates, optimizes, and compares the performance of solar photovoltaic cells based on two different promising Pb‐free double perovskite absorber materials viz. (FA)2BiCuI6 and Cs2AgBi0.75Sb0.25Br6. The optoelectronic properties of these materials indicate high absorption coefficient with minimum reflection coefficients, making them appropriate for photon absorption. The performance of (FA)2BiCuI6 and Cs2AgBi0.75Sb0.25Br6 based modeled cells are examined for several combinations of electron and hole transport materials using SCAPS‐1D and the optimized power conversion efficiency (PCE) of 14.3% and 11.1% are achieved by simulating the architectures FTO/SnO2/(FA)2BiCuI6/Cu2O/Au and FTO/SnO2/Cs2AgBi0.75Sb0.25Br6/Cu2O/Au, respectively. Further, this work employs the bandgap grading scheme to enhance their PCEs. The efficiency of cells further improves to 14.8% and 12.2% credited to the reduction in interfacial recombination with bandgap graded absorber layers. Moreover, the comparative investigations are also done in terms of absorber layer defect density and working temperature. The findings provide valuable insights into designing of highly efficient Pb‐free double perovskite solar cells as the promising alternative to conventional Pb based halide perovskite photovoltaic cells.
A Gallbladder‐Specific Hydrophobic Bile Acid‐FXR‐MUC1 Signaling Axis Mediates Cholesterol Gallstone Formation
Authors: Chen Hongtan , Jiang Xin , Li Yiqiao , Guo Honggang , Wu Jianguo , Li Sha , Hu Fengling , Xu Guoqiang 
Published: February 2025

AbstractDifferences in the distribution of hydrophilic and hydrophobic bile acids (BA) are observed in mouse models of non‐alcoholic fatty liver disease (NAFLD) induced by a high‐fat‐cholesterol “Western‐style” diet (WD), and cholesterol gallstone disease (CGD) induced by a lithogenic diet. Despite sharing common pathological processes, these models exhibit distinct characteristics in their BA pools. The study investigates the impact of hydrophobic BA (HphoBA) and hydrophilic BA (HphilBA) on CGD development using cytochrome‐P450‐2c70 knockout (C70‐KO) mice (miceC70‐KO), genetically modified to resemble humans with a hydrophobic BA pool. All miceC70‐KO fed the WD develop CGD, resembling human cholelithiasis patients, while WD‐fed wild‐type (WT) mice (miceWT) show cholesterol‐saturated bile but rarely form gallstones. Compared to miceWT, WD‐fed miceC70‐KO display caveolae microdomain redistribution in the gallbladder mediated by the HphoBA, FXR, and miR30c/e axis, which enhances the Sp1 transcriptional activity of mucin‐1 (MUC1) genes through nuclear translocation of protein kinase Cζ (PKCζ). These changes contribute to increased production of pronucleating agents (MUC1 and MUC5ac) and accelerate crystallization of gallbladder cholesterol. The data also suggest that WD‐fed miceC70‐KO appropriately model human CGD since lithogenic diet‐fed miceWT have a larger BA pool that masks the negative effects of gallbladder FXR on CGD development.
CircSATB1 Promotes Colorectal Cancer Liver Metastasis through Facilitating FKBP8 Degradation via RNF25‐Mediated Ubiquitination
Authors: Zhang Chuan , Tian Chuanxin , Zhu Renzhong , Chen Chen , Jin Chi , Wang Xiaowei , Sun Lejia , Peng Wen , Ji Dongjian , Zhang Yue , Sun Yueming 
Published: February 2025

AbstractColorectal cancer (CRC) is one of the most common cancers worldwide and liver metastasis is the leading reason for its mortality. Circular RNAs (circRNAs) are conclusively associated with the progression of various cancers, rendering the exploration of its specific mechanisms in colorectal cancer liver metastasis(CRLM) highly valuable. Combined with GEO (Gene Expression Omnibus) databases and clinical data in our center, we found that high expression of circSATB1 is closely related to the progression of CRLM. Functionally, circSATB1 could significantly promote the metastatic ability of CRC cells in vitro and in vivo. Mechanistically, circSATB1 facilitated the RNF25‐mediated ubiquitylation and degradation of FKBP8, releasing its inhibitory effects on mTOR signaling. In this process, circSATB1 acted as a scaffold for RNF25‐FKBP8 complexes. Additionally, circSATB1 could be packaged in exosomes and secreted from the CRC primary tumors into plasma. In conclusion, this study uncovered a new circSATB1 that acts as a potent promoter of CRLM and offers novel insights into the precision therapeutic strategies for CRLM.
Phosphorylation of POU3F3 Mediated Nuclear Translocation Promotes Proliferation in Non‐Small Cell Lung Cancer through Accelerating ATP5PF Transcription and ATP Production
Authors: Zeng Qi‐Gang , Li Le , Chang Tao , Sun Yong , Zheng Bin , Xue Ling‐Na , Liu Chao‐Ling , Li Xia‐Qing , Huang Ruo‐Tong , Gu Jia‐Xin , An Zhao‐Rong , Yao Hao‐Tao , Zhou Dan‐Yang , Fan Jun , Dai Yong 
Published: February 2025

AbstractTargeting oxidative phosphorylation (OXPHOS) through inhibiting the electron transport chain (ETC) has shown promising pre‐clinical efficacy in cancer therapy. Although aerobic glycolysis is a hallmark of cancer, emerging evidence suggest OXPHOS is frequently enhanced, providing metabolic advantages for cell proliferation, metastasis, and drug resistance in a variety of aggressive cancer types including non‐small cell lung cancer (NSCLC), yet the underlying molecular mechanisms remain elusive. Here it is reported that POU‐domain containing family protein POU3F3 is translocated into the nuclei of NSCLC cell lines harboring mutant RAS, where it activates transcription of ATP5PF, an essential component of mitochondrial ATP synthase and consequent ATP production, leading to enhanced NSCLC proliferation and migration. Moreover, it is further found out that ERK1 phosphorylates POU3F3 at the S393 site in the cytoplasm and promotes the nuclear translocation of POU3F3 via receptor importin β1 in RAS mutant NSCLC cells. Mechanistically, RNA sequencing analysis combined with chromatin immunoprecipitation (ChIP) assay revealed that POU3F3 binds to the promoter of ATP5PF, leading to enhanced ATP5PF transcription and ATP production. Together, this study uncovers a novel RAS‐POU3F3‐ATP5PF axis in facilitating NSCLC progression, providing a new perspective on the understanding of molecular mechanisms for NSCLC progression.
Mitochondrial Amount Determines Doxorubicin‐Induced Cardiotoxicity in Cardiomyocytes
Authors: Xiong Weiyao , Li Bin , Pan Jianan , Li Dongjiu , Yuan Haihua , Wan Xin , Zhang Yanjie , Fu Lijun , Zhang Junfeng , Lei Ming , Chang Alex Chia Yu 
Published: February 2025

AbstractDoxorubicin, an anthracycline commonly used for treating cancer patients, is known for its cardiotoxic side‐effects. Although dose‐dependent, but susceptibility remains variable among patients, and childhood‐exposure‐adult‐onset remains challenging. Besides topoisomerase toxicity, Doxorubicin is also toxic to the mitochondria yet the underlying late onset mechanism remains elusive. Here, it is observed that the mitochondrial copy number in PBMCs of patients treated with anthracycline chemotherapy is negatively correlated with the change in plasma BNP levels after treatment. Isogenic hiPSC‐CMs are generated with high, norm, and low mitochondrial copy numbers using mitochondrial transplantation and the YFP‐Parkin system. Remarkably, lower mitochondria copy number translates to lower IC50, suggesting increased susceptibility. Mitochondria supplementation by intramyocardial injection prevents doxorubicin induced heart failure. Mechanistically, doxorubicin treatment leads to mPTP opening and mitochondrial DNA (mtDNA) leakage. This mtDNA leakage event activates the cGAS‐STING pathway and drives inflammation and myocardial senescence. Cardiomyocyte‐specific knockout of Sting (Myh6‐Cre/Stingflox/flox; StingCKO) and over expression of mitochondrial tagged DNase1 in mice partially rescue doxorubicin‐induced cardiac dysfunction. In conclusion, the work establishes a negative correlation between cardiomyocyte mitochondrial copy number and doxorubicin toxicity. Molecularly, it is demonstrated that mtDNA leakage activates cGAS‐STING pathway and accelerates myocardial dysfunction. These insights offer new co‐administration strategies for cancer patients.
Lone Pair and Unique N‐Bridging of Novel Titanium Nitridophosphate
Authors: Ufondu Peter , Sakshi  , Boyko Teak D. , Pointner Monika M. , Schnick Wolfgang , Moewes Alexander 
Published: February 2025

AbstractIn exploring advanced materials for solar power, the novel titanium nitridophosphate (TiP4N8) stands out due to its unique linear nitrogen bridging. To investigate the elemental interactions responsible for the photovoltaic performance under visible light, the titanium L2, 3‐edges and nitrogen K‐edge are specifically explored using X‐ray absorption spectroscopy (XAS), X‐ray emission spectroscopy (XES), and resonant inelastic X‐ray scattering (RIXS) techniques to map the unoccupied and occupied electronic states. It is shown that the indirect interaction between the linear nitrogen bearing the lone pair and titanium is responsible for the bandgap of 1.55 ± 0.30 eV and 1.77 ± 0.30 eV in the β‐ and α‐TiP4N8 phases as well as the stability of the α‐phase. The formal oxidation state of the Ti ion in the β‐ and α‐phases are also validated to be trivalent (Ti+3) and both trivalent (Ti+3) and tetravalent (Ti+4), respectively.
Medium Spiny Neurons Mediate Timing Perception in Coordination with Prefrontal Neurons in Primates
Authors: Liu Xinhe , Zhang Zhiting , Gan Lu , Yu Panke , Dai Ji 
Published: February 2025

AbstractTiming perception is a fundamental cognitive function that allows organisms to navigate their environment effectively, encompassing both prospective and retrospective timing. Despite significant advancements in understanding how the brain processes temporal information, the neural mechanisms underlying these two forms of timing remain largely unexplored. In this study, it aims to bridge this knowledge gap by elucidating the functional roles of various neuronal populations in the striatum and prefrontal cortex (PFC) in shaping subjective experiences of time. Utilizing a large‐scale electrode array, it recorded responses from over 3000 neurons in the striatum and PFC of macaque monkeys during timing tasks. The analysis classified neurons into distinct groups and revealed that retrospective and prospective timings are governed by separate neural processes. Specifically, this study demonstrates that medium spiny neurons (MSNs) in the striatum play a crucial role in facilitating these timing processes. Through cell‐type‐specific manipulation, it identified D2‐MSNs as the primary contributors to both forms of timing. Additionally, the findings indicate that effective processing of timing requires coordination between the PFC and the striatum. In summary, this study advances the understanding of the neural foundations of timing perception and highlights its behavioral implications.
Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy
Authors: Wang Jiasheng , Guo Peng , Wu Dongmei , Yi Junzhi , Jiang Qi , Hu Jiajie , Ouyang Hongwei 
Published: February 2025

AbstractOsteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology is related to the local accumulation of senescent cells (SnCs). However, existing SnCs‐scavenging drugs “senolytics” may lead to the exhaustion of stem and progenitor cells, impairing chondrocyte proliferation and cartilage regeneration. Here, ADAM19, a kind of endopeptidases from the ADAM (a disintegrin and metalloproteinase) family, is identified as a novel target for senescent chondrocyte rejuvenation. ADAM19 is elevated in senescent chondrocytes in both mice and human osteoarthritic joints, as well as in cellular senescence model in vitro. ADAM19 knockdown not only significantly attenuated senescent phenotype of chondrocytes, but also promoted cell proliferation and extracellular matrix synthesis. RNA sequencing revealed ADAM19 may regulate chondrocyte senescence mainly through the PI3K/AKT signal axis. In addition, a senescence‐targeting small interfering RNA (siRNA) delivery system is developed for in vivo delivery of therapeutic siRNA. The complex selectively released ADAM19 siRNA in SnCs and performed high silencing effect on target gene. Furthermore, intra‐articular (IA) injection of the complex once every two weeks in OA mice effectively reduced SnCs accumulation and promoted hyaline cartilage regeneration. This study provides a promising strategy for the development of regenerative RNA interference therapy.
Hybrid Electro‐optical Stimulation Improves Ischemic Brain Damage by Augmenting the Glymphatic System
Authors: Kim Min Jae , Youn Jiman , Lee Hong Ju , Lee Seo‐Yeon , Kim Tae‐Gyu , Jung Young‐Jin , Shin Yong‐Il , Choi Byung Tae , Jeong Joonsoo , Shin Hwa Kyoung 
Published: February 2025

AbstractIschemic brain injury not only results in significant neurological, motor, and cognitive impairment but also contributes to the accumulation of toxic solutes and proinflammatory cytokines in the infarction region, exacerbating ischemic brain damage. The glymphatic system, which is crucial for brain waste clearance and homeostasis, is impaired by ischemic injury, highlighting the importance of developing therapeutic strategies for poststroke complications. Herein, a novel hybrid electro‐optical stimulation device is proposed that integrates near‐infrared micro‐light‐emitting diode with transparent microneedles, enabling efficient noninvasive stimulation of the cortical area for ischemic stroke treatment. This study investigates whether this hybrid electro‐optical stimulation enhances the glymphatic system function and ameliorates ischemic brain injury in the middle cerebral artery occlusion and reperfusion (MCAO/R) mice model. The results demonstrate that hybrid stimulation improves the neurological, motor, and cognitive functions and reduces brain atrophy following MCAO/R. Moreover, hybrid stimulation restores impaired glymphatic system function by modulation of aquaporin‐4 (AQP4) polarization and alleviates the accumulation of proinflammatory cytokines such as IL‐1β. Notably, AQP4 inhibition partly reverses the improved functional outcomes of hybrid stimulation. The findings suggest that targeting glymphatic drainage using hybrid electro‐optical stimulation is a promising therapeutic approach for treating ischemic brain injury.
Elemental Stability Rules for High Entropy Disordered Rocksalt Type Li‐Ion Battery Positive Electrodes
Authors: Wang Lin , Sunariwal Neelam , He Yufang , Kim Do‐hoon , Yeon Dong‐hee , Zeng Yan , Cabana Jordi , Ouyang Bin 
Published: February 2025

AbstractHigh entropy disordered rocksalt (HE‐DRX) Li‐ion battery positive electrodes have gained attention as a potential alternative to commercialized positive electrodes, aiming to eliminate or minimize the use of Ni/Co while maintaining competitive electrochemical performance. Despite their potential, understanding the intricate elemental stability across the vast HE‐DRX chemical landscape remains a significant challenge. In this study, we tackle this challenge by conducting a comprehensive data‐driven phase diagram analysis of 18810 potential HE‐DRX compositions, each featuring common Li and F stoichiometries. Leveraging a charge balance algorithm, we systematically explore redox stability and phase stability, unveiling critical insights into chemical stability rules within the HE‐DRX design space. The analysis also uncovers untapped potential of Cu as redox‐active centers, with Sb and Sn contributing as stable charge compensators. The utilization of these elements is seldom reported in the literature but has been validated by the successful experimental synthesis of materials Li21Zr3Ti3Mn2Fe5Cu2O36 and Li21Mn2Ti3Fe5Cu2Sn3O36.
PC‐Derived SEI Film to Stabilize Graphite|Electrolyte Interface in Sulfone‐Based Electrolyte for Advanced Lithium‐Ion Batteries
Authors: Yan Xinan , Chen Kean , Chen Hui , Chen Zhongxue , Ai Xinping , Cao Yuliang 
Published: February 2025

AbstractSolid electrolyte interphase (SEI) plays a crucial role in stabilizing the anode‐electrolyte interface of lithium‐ion batteries. To date, extensive efforts are dedicated to the regulation of the SEI's compositions, instead the dissolution of the SEI in the electrolyte, an important factor that significantly influences the interfacial stability, received less attention. In this work, it is discovered for the first time that the dissolution of propylene carbonate (PC)‐derived SEI can be restrained by employing tetramethylene sulfone (TMS) as the main solvent, thereby markedly enhancing the interfacial stability of Li||graphite half‐cell and high‐voltage graphite||LiCoO2 full cell. Undoubtedly, this work provides a new electrolyte design principle for developing many solvents that are previously considered detrimental in batteries to establish robust interfaces by minimizing the solubility of SEI.
Configuration Design and Interface Reconstruction to Realize the Superior High‐Rate Performance for Sodium Layered Oxide Cathodes
Authors: Zhang Jiandong , Yu Zhaoshi , Zhu Yanbin , Cai Jingyao , Wang Muqin , Gao Pengkun , Zhang Yali , Zhang Naiqing , Wang Deyu , Shen Yan , Wang Mingkui 
Published: February 2025

AbstractCharge transfer at the electrode/electrolyte interface and mass transfer within the electrode are the two main factors affecting the high‐rate performance of O3‐type layered oxide cathodes for sodium‐ion batteries. Here a multidimensional lanthurization strategy is proposed to construct the surface LaCrO3 heterostructure and create a Cr─O─La configuration for O3‐type NaCrO2. The electrified heterogeneous LaCrO3 induces a built‐in electric field to accelerate charge transfer at the interface. Meanwhile, the Cr─O─La configuration in the transition metal layer leads to local charge aggregation, weakens the interaction force between Na─O, and reduces the Na+ migration barrier. This strategy significantly improves the electrochemical reaction kinetics and the structural reversibility of the layered oxide cathode. As a result, the designed stoichiometric ratio Na0.94Cr0.98La0.02O2 electrode exhibits remarkable rate performance (101.8 mAh g−1 at 40 C) as well as outstanding cycling stability (83.1% capacity retention at 20 C for 2000 cycles) in a half‐cell, along with a competitive full battery performance (89.3% after 500 cycles at 2 C). This study provides a promising route to achieve capacity presentation and retention of layered oxide cathode materials at high‐rate.
Antiphase alternating‐pulse fluidized bed for improving the fluidization quality: An Eulerian–Eulerian study
Authors: Zhang Lingjie , Du Jiali , Wu Feng , Wang Junwu , Ma Xiaoxun 
Published: February 2025

AbstractTo address poor radial mixing in conventional pulsed fluidized beds (PFB), a novel antiphase alternating‐pulse fluidized bed (AAPFB) is proposed to improve the fluidization quality by combining a well‐designed air distributor and a non‐steady‐state gas intake technique. Detailed analysis of flow field differences among uniform flow fluidized bed (UFB), PFB, and AAPFB was conducted through numerical simulations, with a particular focus on examining variations in dispersion coefficients, elucidating the mechanism of the regulation of the flow fields by antiphase alternating pulsed airflow. The study also explored the modulation of inlet waveform, pulse frequency and vibration amplitude on flow characteristics. Results indicated that (i) AAPFB achieves uniform particle disturbance, significantly enhancing gas and particle dispersion; (ii) Rectangular flow improves particle distribution more than sinusoidal and triangular flows; and (iii) A 1 Hz pulse frequency and 0.3um amplitude optimally balances flow disturbances and bubble dynamics, resulting in superior dispersion for gas and particles.
Highly efficient propyne semihydrogenation over tin‐modified Co‐based intermetallic catalyst
Authors: Bian Ziqi , Chen Minhao , Ge Xiaohu , Zhu Ningchao , Cao Yueqiang , Jiang Hao , Zhang Jing , Qian Gang , Zhou Xinggui , Duan Xuezhi 
Published: February 2025

AbstractDesigning and fabricating uniformly dispersed non‐precious metal active sites with tuned geometric configurations and local coordination environments for the selective conversion of functional groups to desired products is of great importance but remains challenging in industrial catalytic processes. In this work, we propose a straightforward method for synthesizing the Co3Sn2 intermetallic catalyst through the structural conversion of layered double hydroxide precursors, thereby constructing suitable Sn‐modified Co active sites and an optimized catalytic environment for propyne semihydrogenation. Characterizations using x‐ray diffraction, high‐resolution transmission electron microscopy, and x‐ray absorption spectroscopy characterizations are combined to identify the formation of P63/mmc Co3Sn2 intermetallic phase. Catalytic performance tests show that the Co3Sn2 catalyst achieves 95.0% propylene selectivity with nearly complete propyne conversion. Temperature‐programmed surface reaction and desorption measurements combined with theoretical calculations demonstrate that the good selectivity is driven by the facile desorption of propylene from Sn‐modified Co sites rather than its further hydrogenation.
Engineering homointerface‐mediated mixed matrix membrane for propylene/propane separation
Authors: Niu Xinpu , Liu Zongkai , Zhao Haofan , Wang Jing , Dong Guanying , Zhang Yatao 
Published: February 2025

AbstractAchieving seamless integration between polymer‐filler remains a significant challenge in gas separation mixed matrix membranes (MMMs), particularly with glassy polymers of intrinsic microporosity (PIMs). Here, we report a homointerface strategy for fabricating high‐performance MMMs by the modulated synthesis of zeolitic imidazolate framework ZIF‐8 fillers with amidoxime‐modified polymer of intrinsic microporosity (AOPIM‐1) oligomers, followed by being encapsulated within the long‐chain AOPIM‐1 polymer matrix. These AOPIM‐1 oligomers serve a dual role: precisely modulating the crystal growth of ZIF‐8 and establishing intimate homointerfaces between polymer‐filler due to their intervening linker function. This strategy ensures excellent filler dispersion while preserving their interconnected network structure within MMMs, offering abundant percolating nanochannels. The resulting MMMs exhibited remarkably enhanced C3H6/C3H8 separation performance, with optimal combinations of C3H6 permeability (184.5–267.6 Barrer) and C3H6/C3H8 selectivity (23.9–28.9) outperforming state‐of‐the‐art metal–organic frameworks (MOF)‐based MMMs. This strategy presents an alternative strategy for the design of efficient MOFs/PIMs MMMs in the separation of challenging gas mixtures.