bluuebunny/crossref_metadata_2025_split huggingface dataset:
Four-bar linkage reconfigurable robotic wheel: Design, kinematic analysis, and experimental validation for adaptive size modification
Authors: Sandoval-Castro X. Yamile , Muñoz-Gonzalez Sergio , Garcia-Murillo Mario A. , Ferrusca-Monroy Pedro D. , Ruiz-Torres Maxiamiano F. 
Published: May 2024

AbstractThis article presents the development of a robot capable of modifying its size through a wheel reconfiguration strategy. The reconfigurable wheel design is based on a four-bar retractable mechanism that achieves variation of the effective radius of the wheel. A reconfiguration index is introduced based on the number of retractable mechanisms that predicts the radius of configuration according to the number of mechanisms implemented in the wheel. The kinematics of the retractable mechanism is studied to determine the theoretical reconfiguration radius during the transformation process, it is also evaluated numerically with the help of the GeoGebra software, and it is validated experimentally by image analysis using the Tracker software. The transformation process of the robot is investigated through an analysis of forces that consider the wheel in contact with the obstacle, the calculation of the wheel torque and the height of the obstacle to be overcome are presented. On the other hand, the experimental validation of the robot reconfiguration process is presented through the percentage of success shown by the robot to overcome obstacles of 50, 75, 100 and 125 mm. In addition, measurements of energy consumption during the transformation process are reported. Reconfigurable wheels, capable of adapting their size, offer innovative solutions to various challenges across different applications such as robotic exploration and search and rescue missions to industrial settings. Some key issues that these wheels can address include terrain adaptability enhancing a robot’s mobility over uneven surfaces, or obstacles; enhanced robotic design; cost-effective design; space efficiency; and versatility in applications.
Improving national bird population estimates in Europe: insights from comparisons with atlas abundance data
Authors: Herrando Sergi , Fraixedas Sara , Brotons Lluís , Martí David , Staneva Anna , Keller Verena , Voříšek Petr , Burfield Ian J. 
Published: May 2024

Summary
In Europe, population estimates of breeding birds are produced nationally and are periodically compiled at EU or pan-European scales. Until now, no other source was available to explore the robustness of these estimates. In this study, we compared population sizes reported in the latest edition of the European Red List of Birds (ERLoB) with those produced using data from the second European Breeding Bird Atlas (EBBA2) to assess their consistency and determine parameters behind variability in population estimates that deserve further attention in the future. In general, European population estimates derived from summing local abundance data from EBBA2 were similar to those obtained from ERLoB, although for some species they differed considerably, particularly in those distributed mainly in southern Europe. National population estimates from EBBA2 also did not differ markedly from those in ERLoB. However, we found that EBBA2 provided larger national population sizes than ERLoB for widespread species, suggesting that spatial information is more relevant for properly assessing their population size than for localised species. Our analysis also showed that, in general, population estimates based on robust methodological protocols (e.g. complete counts, statistical inference) contributed to reducing differences between ERLoB and EBBA2 values. Interestingly, EBBA2 and ERLoB estimates were quite similar for species classified in Europe as “Threatened” or “Near Threatened”, whereas the values for “Least Concern” species were consistently different between these two sources. Our results indicate which type of species would benefit from additional efforts to improve national population estimates and their consistency across countries, issues that are of paramount importance for guiding conservation strategies in Europe.
Logical characterizations of algebraic circuit classes over integral domains
Authors: Barlag Timon , Chudigiewitsch Florian , Gaube Sabrina A. 
Published: May 2024

AbstractWe present an adapted construction of algebraic circuits over the reals introduced by Cucker and Meer to arbitrary infinite integral domains and generalize the
$\mathrm{AC}_{\mathbb{R}}$
and
$\mathrm{NC}_{\mathbb{R}}^{}$
classes for this setting. We give a theorem in the style of Immerman’s theorem which shows that for these adapted formalisms, sets decided by circuits of constant depth and polynomial size are the same as sets definable by a suitable adaptation of first-order logic. Additionally, we discuss a generalization of the guarded predicative logic by Durand, Haak and Vollmer, and we show characterizations for the
$\mathrm{AC}_{R}$
and
$\mathrm{NC}_R^{}$
hierarchy. Those generalizations apply to the Boolean
$\mathrm{AC}$
and
$\mathrm{NC}$
hierarchies as well. Furthermore, we introduce a formalism to be able to compare some of the aforementioned complexity classes with different underlying integral domains.
An ultra-wideband power amplifier designed through a bandwidth expansion strategy
Authors: Xuan Xuefei , Cheng Zhiqun , Hayes Brendan , Zhang Zhiwei , Gong Tingwei , Wu Shenbing , Le Chao 
Published: May 2024

AbstractA bandwidth expansion strategy for ultra-wideband power amplifiers (PAs) is presented in this letter by adopting a parallel impedance matching architecture. This design strategy can effectively reduce the impedance conversion ratio between the load and the target impedance of the PA, thereby providing a feasible solution for broadband impedance matching. Subsequently, a commercially available 10 W gallium nitride device and a two-stage Wilkinson power divider network are combined to achieve the verification of the proposed theory. The results of the measurement show that within the target frequency band of 0.9–3.9 GHz, 58.5–71.2% of the drain efficiency and 9.1–12 dB of gain can be achieved with a saturated output power of 39.1–42 dBm.
Tidal Heating in a Subsurface Magma Ocean on Io Revisited
Authors: Aygün B. , Čadek O. 
Published: May 2024

AbstractWe investigate the tidal dissipation in Io's hypothetical fluid magma ocean using a new approach based on the solution of the 3D Navier‐Stokes equations. Our results indicate that the presence of a shallow magma ocean on top of a solid, partially molten layer leads to an order of magnitude increase in dissipation at low latitudes. Tidal heating in Io's magma ocean does not correlate with the distribution of hot spots, and is maximum for an ocean thickness of about 1 km and a viscosity of less than 104 Pa s. Due to the Coriolis effect, the k2 Love number can depend on the harmonic order. We show that the analysis of k2 may not reveal the presence of a fluid magma ocean if the ocean thickness is less than 2 km. If the fluid layer is thicker than 2 km, k20 ≈ k22/2 ≈ 0.7.
Feasibility and safety of the discontinuation of systemic immunosuppressive treatment after single-unit cord blood transplantation in adults
Authors: Konuma Takaaki , Monna-Oiwa Maki , Kato Seiko , Isobe Masamichi , Nannya Yasuhito , Takahashi Satoshi 
Published: May 2024

AbstractWe retrospectively evaluated the incidence, factors, and clinical outcomes of the discontinuation of immunosuppressive treatment (IST) after single-unit unrelated cord blood transplantation (CBT) in adults receiving cyclosporine-based graft-versus-host disease (GVHD) prophylaxis at our institute. Among the 309 patients who achieved engraftment, 247 were able to discontinue IST with a median follow-up of 121 months for survivors. The cumulative incidence of the discontinuation of IST was 46.2% at 180 days, 72.8% at 2 years, and 79.3% at 5 years post-CBT. In the multivariate analysis, discontinuation of IST after CBT was significantly associated with the requirement for steroid therapy (hazard ratio [HR]: 0.46; P < 0.001) and the recent calendar year of CBT (HR: 1.79; P < 0.001). In the conditional landmark analysis at 180 days, discontinuation of IST was not associated with the development of extensive chronic GVHD (HR: 1.00; P = 0.989), non-relapse mortality (HR: 0.49; P = 0.122), relapse (HR: 1.46; P = 0.388), or overall survival (HR: 1.91; P = 0.065). Our data showed that successful discontinuation of IST is common after single-unit CBT in adults. Discontinuation of IST did not affect subsequent outcomes, suggesting that discontinuation of IST is both feasible and safe in adults undergoing single-unit CBT.
Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner
Authors: Lee Peter W. T. , Suwa Tatsuya , Kobayashi Minoru , Yang Hui , Koseki Lina R. , Takeuchi Satoshi , Chow Christalle C. T. , Yasuhara Takaaki , Harada Hiroshi 
Published: May 2024

Abstract
Background
Cancer cells in severely hypoxic regions have been reported to invade towards tumour blood vessels after surviving radiotherapy in a postirradiation reoxygenation- and hypoxia-inducible factor (HIF)-dependent manner and cause recurrence. However, how HIF induces invasiveness of irradiated and reoxygenated cancer cells remains unclear.

Methods
Here, we identified human minor histocompatibility antigen 1 (HMHA1), which has been suggested to function in cytoskeleton dynamics and cellular motility, as a responsible factor and elucidated its mechanism of action using molecular and cellular biology techniques.

Results
HMHA1 expression was found to be induced at the transcription initiation level in a HIF-dependent manner under hypoxia. Boyden chamber invasion assay revealed that the induction of HMHA1 expression is required for the increase in invasion of hypoxic cancer cells. Reoxygenation treatment after ionising radiation in vitro that mimics dynamic changes of a microenvironment in hypoxic regions of tumour tissues after radiation therapy further enhanced HMHA1 expression and invasive potential of HMHA1 wildtype cancer cells in ROS- and HIF-dependent manners, but not of HMHA1 knockout cells.

Conclusion
These results together provide insights into a potential molecular mechanism of the acquisition of invasiveness by hypoxic cancer cells after radiotherapy via the activation of the ROS/HIF/HMHA1 axis.
Actionability and familial uptake following opportunistic genomic screening in a pediatric cancer cohort
Authors: Hammer-Hansen Sophia , Stoltze Ulrik , Bartels Emil , Hansen Thomas van Overeem , Byrjalsen Anna , Tybjærg-Hansen Anne , Juul Klaus , Schmiegelow Kjeld , Tfelt Jacob , Bundgaard Henning , Wadt Karin , Diness Birgitte Rode 
Published: May 2024

AbstractThe care for patients with serious conditions is increasingly guided by genomic medicine, and genomic medicine may equally transform care for healthy individual if genomic population screening is implemented. This study examines the medical impact of opportunistic genomic screening (OGS) in a cohort of patients undergoing comprehensive genomic germline DNA testing for childhood cancer, including the impact on their relatives. Medical actionability and uptake after cascade testing in the period following disclosure of OGS results was quantified. A secondary finding was reported to 19/595 (3.2%) probands primarily in genes related to cardiovascular and lipid disorders. After a mean follow up time of 1.6 years (Interquartile range (IQR): 0.57-1.92 yrs.) only 12 (63%) of these variants were found to be medically actionable. Clinical follow up or treatment was planned in 16 relatives, and as in the probands, the prescribed treatment was primarily betablockers or cholesterol lowering therapy. No invasive procedures or implantation of medical devices were performed in probands or relatives, and no reproductive counseling was requested. After an average of 1.6 years of follow-up 2.25 relatives per family with an actionable finding had been tested. This real-world experience of OGS grants new insight into the practical implementation effects and derived health care demands of genotype-first screening. The resulting health care effect and impact on demand for genetic counseling and workup in relatives extends beyond the effect in the probands.
Transcriptomic evidence of erythropoietic adaptation from the International Space Station and from an Earth-based space analog
Authors: Trudel Guy , Stratis Daniel , Rocheleau Lynda , Pelchat Martin , Laneuville Odette 
Published: May 2024

AbstractSpace anemia affects astronauts and the underlying molecular alterations remain unknown. We evaluated the response of erythropoiesis-modulating genes to spaceflight through the analysis of leukocyte transcriptomes from astronauts during long-duration spaceflight and from an Earth model of microgravity. Differential expression analysis identified 50 genes encoding ribosomal proteins with reduced expression at the transition to bed rest and increased during the bed rest phase; a similar trend was observed in astronauts. Additional genes associated with anemia (15 genes), erythrocyte maturation (3 genes), and hemoglobin (6 genes) were down-regulated during bed rest and increased during reambulation. Transcript levels of the erythropoiesis transcription factor GATA1 and nine of most enriched erythrocyte proteins increased at reambulation after bed rest and at return to Earth from space. Dynamic changes of the leukocyte transcriptome composition while in microgravity and during reambulation supported an erythropoietic modulation accompanying the hemolysis of space anemia and of immobility-induced anemia.
Thermal evolution of spin excitations in honeycomb Ising antiferromagnetic FePSe3
Authors: Chen Lebing , Teng Xiaokun , Hu Ding , Ye Feng , Granroth Garrett E. , Yi Ming , Chung Jae-Ho , Birgeneau Robert J. , Dai Pengcheng 
Published: May 2024

AbstractWe use elastic and inelastic neutron scattering (INS) to study the antiferromagnetic (AF) phase transitions and spin excitations in the two-dimensional (2D) zig-zag antiferromagnet FePSe3. By determining the magnetic order parameter across the AF phase transition, we conclude that the AF phase transition in FePSe3 is first-order in nature. In addition, our INS measurements reveal that the spin waves in the AF ordered state have a large easy-axis magnetic anisotropy gap, consistent with an Ising Hamiltonian, and possible biquadratic magnetic exchange interactions. On warming across TN, we find that dispersive spin excitations associated with three-fold rotational symmetric AF fluctuations change into FM spin fluctuations above TN. These results suggest that the first-order AF phase transition in FePSe3 may arise from the competition between C3 symmetric AF and C1 symmetric FM spin fluctuations around TN, in place of a conventional second-order AF phase transition.
Linking CRISPR–Cas9 double-strand break profiles to gene editing precision with BreakTag
Authors: Longo Gabriel M. C. , Sayols Sergi , Kotini Andriana G. , Heinen Sabine , Möckel Martin M. , Beli Petra , Roukos Vassilis 
Published: May 2024

AbstractCas9 can cleave DNA in both blunt and staggered configurations, resulting in distinct editing outcomes, but what dictates the type of Cas9 incisions is largely unknown. In this study, we developed BreakTag, a versatile method for profiling Cas9-induced DNA double-strand breaks (DSBs) and identifying the determinants of Cas9 incisions. Overall, we assessed cleavage by SpCas9 at more than 150,000 endogenous on-target and off-target sites targeted by approximately 3,500 single guide RNAs. We found that approximately 35% of SpCas9 DSBs are staggered, and the type of incision is influenced by DNA:gRNA complementarity and the use of engineered Cas9 variants. A machine learning model shows that Cas9 incision is dependent on the protospacer sequence and that human genetic variation impacts the configuration of Cas9 cuts and the DSB repair outcome. Matched datasets of Cas9 and engineered variant incisions with repair outcomes show that Cas9-mediated staggered breaks are linked with precise, templated and predictable single-nucleotide insertions, demonstrating that a scission-based gRNA design can be used to correct clinically relevant pathogenic single-nucleotide deletions.
Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial
Authors: Ryan Donna H. , Lingvay Ildiko , Deanfield John , Kahn Steven E. , Barros Eric , Burguera Bartolome , Colhoun Helen M. , Cercato Cintia , Dicker Dror , Horn Deborah B. , Hovingh G. Kees , Jeppesen Ole Kleist , Kokkinos Alexander , Lincoff A. Michael , Meyhöfer Sebastian M. , Oral Tugce Kalayci , Plutzky Jorge , van Beek André P. , Wilding John P. H. , Kushner Robert F. 
Published: May 2024

AbstractIn the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease, overweight or obesity, without diabetes. Here in this prespecified analysis, we examined effects of semaglutide on weight and anthropometric outcomes, safety and tolerability by baseline body mass index (BMI). In patients treated with semaglutide, weight loss continued over 65 weeks and was sustained for up to 4 years. At 208 weeks, semaglutide was associated with mean reduction in weight (−10.2%), waist circumference (−7.7 cm) and waist-to-height ratio (−6.9%) versus placebo (−1.5%, −1.3 cm and −1.0%, respectively; P < 0.0001 for all comparisons versus placebo). Clinically meaningful weight loss occurred in both sexes and all races, body sizes and regions. Semaglutide was associated with fewer serious adverse events. For each BMI category (<30, 30 to <35, 35 to <40 and ≥40 kg m−2) there were lower rates (events per 100 years of observation) of serious adverse events with semaglutide (43.23, 43.54, 51.07 and 47.06 for semaglutide and 50.48, 49.66, 52.73 and 60.85 for placebo). Semaglutide was associated with increased rates of trial product discontinuation. Discontinuations increased as BMI class decreased. In SELECT, at 208 weeks, semaglutide produced clinically significant weight loss and improvements in anthropometric measurements versus placebo. Weight loss was sustained over 4 years. ClinicalTrials.gov identifier: NCT03574597.
Brain clearance is reduced during sleep and anesthesia
Authors: Miao Andawei , Luo Tianyuan , Hsieh Bryan , Edge Christopher J. , Gridley Morgan , Wong Ryan Tak Chun , Constandinou Timothy G. , Wisden William , Franks Nicholas P. 
Published: May 2024

AbstractIt has been suggested that the function of sleep is to actively clear metabolites and toxins from the brain. Enhanced clearance is also said to occur during anesthesia. Here, we measure clearance and movement of fluorescent molecules in the brains of male mice and show that movement is, in fact, independent of sleep and wake or anesthesia. Moreover, we show that brain clearance is markedly reduced, not increased, during sleep and anesthesia.
Climate change as observed through the IMS radionuclide station in Spitzbergen
Authors: Kuśmierczyk-Michulec Jolanta , Baré Jonathan 
Published: May 2024

AbstractThe International Monitoring System (IMS), installed and maintained by the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) with the support of States Signatories, is a global system of monitoring stations based on four complementary technologies: seismic, hydroacoustic, infrasound and radionuclide. One of the IMS radionuclide stations is located in Spitzbergen, the largest island of the Norwegian Svalbard Archipelago, which borders the Barents Sea and the Northern Atlantic Ocean. It has been demonstrated that signs of climate change are particularly noticeable in that region. As many other radionuclides observed in environmental measurements, 212Pb is always observed at IMS stations, in varying quantities. This is also the case for the IMS station RN49, Spitzbergen, where it can be demonstrated that the average concentration of the measured lead 212Pb increases. This is observable specifically October through December. This paper demonstrates the asset of IMS data to study climate change effects. Our conclusions are supported by global temperature anomaly data from NOAA’s Global Surface Temperature Analysis, covering the period 1850 to 2023.
Novel sustainable steel fiber reinforced preplaced aggregate concrete incorporating Portland limestone cement
Authors: Saleh Majed Ali , Su Zhihao , Zhang Ji 
Published: May 2024

AbstractThis study proposes a novel approach by adding Portland limestone cement (PLC) to preplaced aggregate steel fiber reinforced concrete (PASFRC) to create a sustainable concrete that minimizes CO2 emissions and cement manufacturing energy usage. The method involves injected a flowable grout after premixing and preplacing steel-fibers and aggregates in the formwork. This study evaluates the mechanical properties of a novel sustainable concrete that uses PLC and steel fibers. To achieve the intended objective, long and short end-hooked steel fibers of 1%, 2%, 3%, and 6% were incorporated in PASFRC. Also, Analysis of variance (ANOVA) was used to examine the data. Results indicated that PLC and higher fiber doses increased the mechanical properties of PAC. At 90 days, PASFRC mixtures containing 6% long steel fibers demonstrated superior compressive, tensile, and flexural strengths, registering the highest values of 49.8 MPa, 7.7 MPa, and 10.9 MPa, respectively and differed by 188%, 166%, and 290%, respectively from fiberless PAC. The study confirmed the suitability and effectiveness of using PLC with steel fibers in PAC which significantly improved the mechanical properties of PASFRC. This was verified through analytical analysis and new empirical equations were proposed to predict the mechanical properties of PASFRC.
Archaeobotanical evidence supports indigenous cucurbit long-term use in the Mesoamerican Neotropics
Authors: Domic Alejandra I. , VanDerwarker Amber M. , Thakar Heather B. , Hirth Kenneth , Capriles José M. , Harper Thomas K. , Scheffler Timothy E. , Kistler Logan , Kennett Douglas J. 
Published: May 2024

AbstractThe squash family (Cucurbitaceae) contains some of the most important crops cultivated worldwide and has played an important ecological, economic, and cultural role for millennia. In the American tropics, squashes were among the first cultivated crop species, but little is known about how their domestication unfolded. Here, we employ direct radiocarbon dating and morphological analyses of desiccated cucurbit seeds, rinds, and stems from El Gigante Rockshelter in Honduras to reconstruct human practices of selection and cultivation of Lagenaria siceraria, Cucurbita pepo, and Cucurbita moschata. Direct radiocarbon dating indicates that humans started using Lagenaria and wild Cucurbita starting ~ 10,950 calendar years before present (cal B.P.), primarily as watertight vessels and possibly as cooking and drinking containers. A rind directly dated to 11,150–10,765 cal B.P. represents the oldest known bottle gourd in the Americas. Domesticated C. moschata subsequently appeared ~ 4035 cal B.P., followed by domesticated C. pepo ~ 2190 cal B.P. associated with increasing evidence for their use as food crops. Multivariate statistical analysis of seed size and shape show that the archaeological C. pepo assemblage exhibits significant variability, representing at least three varieties: one similar to present-day zucchini, another like present-day vegetable marrow, and a native cultivar without modern analogs. Our archaeobotanical data supports the hypothesis that Indigenous cucurbit use started in the Early Holocene, and that agricultural complexity during the Late Holocene involved selective breeding that encouraged crop diversification.