bluuebunny/crossref_metadata_2025_split huggingface dataset:
68Ga-markierte Peptide für klinische Studien
Authors: Angerstein C. , Liersch T. , Ghadimi M. , Sahlmann C.-O. , Meller J. , Meller B. 
Published: January 2012

SummaryThe AMG implies far-reaching implications for the synthesis of new radiopharmaceuticals for clinical trials. Aim, methods: As a part of the DFG-funded Clinical Research Group (KFO 179) a project designated „Immuno-PET for assessment of early response to radiochemotherapy of advanced rectal cancer“ was initiated. This trial is focused on a trivalent bispecific humanized monoclonal antibody, and a 68Ga-labeled peptide. Following the new regulatory framework we established a GMPcompliant cleanroom laboratory and applied for a manufacturing permission. Results: During the project constructural, personnel and organizational conditions for a successful application were established, including a quality management system. A GMP-conform cleanroom laboratory class C was constructed, equipped with a two-chamber lock. The actual manufacturing is performed in a closed system with subsequent sterile filtration. The manufacturing processes have been automatised and validated as well as the necessary quality controls. The manufacturing permission was granted after an official inspection. Conclusions: The new German Drug Act is considered as a break in the production practice of nuclear medicine. The early involvement and communication with the authorities avoids time-consuming and costly planning errors. It is much to be hoped that the new legal situation in Germany will not cause serious impairments in the realization of clinical trials in German nuclear medicine.
Results of a National Survey on Over-The-Counter Medicines, Part 1: Pharmacist Opinion on Current Scheduling Status
Authors: Taylor Jeff , Landry Eric , Lalonde Lyne , Tsuyuki Ross T. 
Published: January 2012

Background: OTC medicines make up an important part of the community pharmacy world. As with most aspects of practice, however, hurdles exist that prevent an optimal level of care. Objective: To gauge pharmacist agreement on the scheduling status of various OTC medicines. Methods: Pharmacists across Canada were surveyed by mail. Results: Of the 5037 surveys mailed, 2403 were returned, with 2305 being usable for analysis (response rate of 49.4%). Across 25 agents, pharmacists tended to support existing control for pharmacies (such as Nix crème rinse and minoxidil topical solution) and returning control to pharmacies for unscheduled agents (such as ranitidine 75 mg tablets and nicotine patches). Conclusions: Pharmacists generally favour tighter control of OTC agents, especially those that are unscheduled. This hopefully reflects pharmacist desire to ensure their proper selection and use.
24-Gy Low-Voltage X-Ray Irradiation With Ranibizumab Therapy for Neovascular AMD: 6-Month Safety and Functional Outcomes
Authors: Canton Virgilio Morales , Quiroz-Mercado Hugo , Velez-Montoya Raul , Lopez-Miranda Miriam J. , Moshfeghi Andrew A. , Shusterman Eugene M. , Kaiser Peter K. , Sanislo Steven R. , Gertner Michael , Moshfeghi Darius M. 
Published: January 2012

BACKGROUND AND OBJECTIVE:
To describe the 6-month safety and preliminary efficacy outcomes of the use of 24-Gy radiation with intravitreal ranibizumab for patients with neovascular age-related macular degeneration (AMD).

PATIENTS AND METHODS:
A single treatment of a non-invasive, externally delivered low-voltage x-ray irradiation at a dose of 24 Gy was administered in one session through three locations in the inferior pars plana in a consecutive series of patients with neo-vascular AMD (treatment naïve and previously treated). Optical coherence tomography (OCT) and Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity examinations were performed at 1 week, 1 month, and monthly thereafter with quarterly fluorescein angiography.

RESULTS:
Nineteen patients completed 6 months of follow-up. There was no evidence of radiation retinopathy, optic neuropathy, or cataract. The mean baseline ETDRS score was 38.3 ± 19.5 letters. At 6 months, the corresponding ETDRS score was 44.7 ± 16.8 letters. At 6 months, the mean change in visual acuity was 6.4 ± 9.8 ETDRS letters. Patients received an average of 0.4 additional ranibizumab injections following the initial two mandated injections.

CONCLUSION:
A single treatment of external 24-Gy low-voltage x-ray therapy in conjunction with ranibizumab demonstrated an overall improvement in visual acuity in patients with neovascular AMD at 6 months, with no radiation-related adverse effects.
Five-Year Results of 5-Fluorouracil Augmented Needling Revision of Failing Blebs
Authors: Dalvi Rajesh , Orzech Neil , Kranemann Christoph , Birt Catherine M. 
Published: January 2012

BACKGROUND AND OBJECTIVE:
To report the 5-year intraocular pressure (IOP) outcomes of patients requiring a 5-fluorouracil (5-FU) needling revision compared to a matched sample.

PATIENTS AND METHODS:
Forty eyes receiving 5-FU bleb needling revision were matched to 40 patients not needled. IOP was recorded preoperatively and annually to 5 years. The main outcome measure was surgical success: IOP control without medications or surgery.

RESULTS:

Thirty-two patients with 5-FU needling revision (80.0%) required anti-glaucoma medication postoperatively versus 28 control patients (70%) (
P
> .05). Thirty-two patients with 5-FU needling revision were complete or qualified successes compared to 36 control patients (
P
= .34). Eight patients with 5-FU needling revision (20%) had a reoperation versus 4 control patients (10%) (
P
> .05).

CONCLUSION:
5-FU needling revision can produce long-term IOP control levels similar to those who did not require the procedure. No statistically significant differences between the two groups was seen in either the use of medications or further surgery.
Assessment of mental disorders using the patient health questionnaire as a general screening tool in western Nigeria: A community-based study
Authors: Amoran O.E. , Ogunsemi O.O. , Lasebikan V.O. 
Published: January 2012

ABSTRACT
Background: Screening at the community level will provide keys to promoting health and preventing diseases at the community level and serve as the fulcrum for timely detection and intervention. This study aims to assess the prevalence and nature of mental disorder among the general population using the patient health questionnaire (PHQ). It also compares the use of PHQ and GHQ as general screening tools for mental disorders. Materials and Methods: This community-based study is cross sectional in design. Multistage sampling technique was used to obtain a representative sample of the communities. The PHQ and GHQ-12 questionnaires were concurrently administered by health care workers that were nondoctors to screen for psychiatric symptoms. Results: A total of 758 participants took part in the study, 496 (65.4%) of the subjects had a form of psychopathology or the other using PHQ and 143 (18.9%) using GHQ questionnaire (χ2 = 20.92, P = 0.000). Three hundred and thirty one subjects (43.7%) met the criteria for Somatoform disorder but 6.0% ever treated at PHC, 269 (35.5%) for depression and 4.8% ever treated, 127 (16.8%) for panic disorder and 5.5% ever treated, while 165 (21.8%) for general anxiety and 4.8% ever treated. Predictors of psychopathology were individuals who were singles (OR = 0.64, CI = 0.49-0.93) concerns about their health (OR = 3.06, CI = 2.06-4.56), worried about finance (OR = 1.84, CI = 1.27-2.67), worried about family life (OR = 2.68, CI = 1.61-4.72), and stressed at work (OR = 1.16, CI = 1.06-1.28). Conclusion: There is a high prevalence of psychopathology at the community level in this African population and few had ever been treated. PHQ as a general screening tool has a higher false-positive value compared to GHQ when used by nondoctors. PHQ should be used as an instrument to screen for specific mental disorders rather than a general screening tool for psychiatric morbidity at the community level.
Acute neuromuscular weakness associated with dengue infection
Authors: Hira Harmanjit Singh , Kaur Amandeep , Shukla Anuj 
Published: January 2012

ABSTRACT
Background: Dengue infections may present with neurological complications. Whether these are due to neuromuscular disease or electrolyte imbalance is unclear. Materials and Methods: Eighty-eight patients of dengue fever required hospitalization during epidemic in year 2010. Twelve of them presented with acute neuromuscular weakness. We enrolled them for study. Diagnosis of dengue infection based on clinical profile of patients, positive serum IgM ELISA, NS1 antigen, and sero-typing. Complete hemogram, kidney and liver functions, serum electrolytes, and creatine phosphokinase (CPK) were tested. In addition, two patients underwent nerve conduction velocity (NCV) test and electromyography. Results: Twelve patients were included in the present study. Their age was between 18 and 34 years. Fever, myalgia, and motor weakness of limbs were most common presenting symptoms. Motor weakness developed on 2 nd to 4 th day of illness in 11 of 12 patients. In one patient, it developed on 10 th day of illness. Ten of 12 showed hypokalemia. One was of Guillain-Barré syndrome and other suffered from myositis; they underwent NCV and electromyography. Serum CPK and SGOT raised in 8 out of 12 patients. CPK of patient of myositis was 5098 IU. All of 12 patients had thrombocytopenia. WBC was in normal range. Dengue virus was isolated in three patients, and it was of serotype 1. CSF was normal in all. Within 24 hours, those with hypokalemia recovered by potassium correction. Conclusions: It was concluded that the dengue virus infection led to acute neuromuscular weakness because of hypokalemia, myositis, and Guillain-Barré syndrome. It was suggested to look for presence of hypokalemia in such patients.
Pediatric brainstem oligodendroglioma
Authors: Mohindra Sandeep , Savardekar Amey , Bal Amanjit 
Published: January 2012

ABSTRACTThe authors present the first report of pediatric brainstem oligodendroglioma, infiltrating midbrain, and medulla oblongata. The report details clinical features, radiological findings, and surgical steps. As this entity is exceedingly uncommon, the overall epidemiology, prognosis, and long-term outcome remain far from established.
Meckel-Gruber syndrome: Report of two cases
Authors: Panduranga C. , Kangle Ranjit , Badami Rajshree , Patil Prakash V 
Published: January 2012

ABSTRACTMeckel-Gruber syndrome (MKS) is an autosomal recessive disorder, characterized by a combination of renal cysts and variably associated with features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia, cysts, and polydactyly. It is a rare syndrome with highest incidence in Gujarati Indians and Finnish population. We report two such cases of MKS in non-Gujarati Indian which were diagnosed by neonatal autopsy.
Choroid plexus carcinoma in an adult
Authors: Kishore Sanjeev , Negi Gita , Meena Harsh , Anuradha Kusum , Pathak Prakash Ved , Bansal K.K. 
Published: January 2012

ABSTRACTChoroid plexus carcinoma is a very rare tumor in adults. Here we report a rare case of choroid plexus carcinoma in an adult patient. A 24-year-old male presented with a right temporal intraventricular tumor with a cystic component also extending up to the cortex. Histological examination revealed complex papillary structures and glandular spaces showing stratification and multilayering of cells with nuclear crowding and numerous mitotic figures and large areas of necrosis. The patient went through a complete search for a possible primary keeping in mind the differential diagnosis of metastatic carcinoma that is more common in adults but there was no evidence of any other tumor. Finally a diagnosis of choroid plexus carcinoma was rendered. Immunohistochemical analysis for p53 protein showed positivity. Choroid plexus carcinoma is exceptionally rare in adults but cases do occur.
An unusual case of unilateral limb hypertrophy: Lipoma of sacral roots
Authors: Netto Archana B , Sinha Sanjib , Taly Arun B , Prasad Chandrajit , Mahadevan A , Bindu PS , Sidhu Ravinder J , Yasha TC 
Published: January 2012

ABSTRACTWe report an unusual case of unilateral limb pseudo hypertrophy in a 21-year-old lady who developed progressive enlargement of the right calf followed by thigh in association with chronic leg pain. Magnetic resonance imaging (MRI) of the affected limb confirmed enlargement of various muscles. Electromyography revealed neurogenic features consistent with S1 radiculopathy. MRI of the lumbosacral spine showed tethered cord with a lipoma infiltrating multiple sacral roots. Our case illustrates that muscular pseudo hypertrophy may follow chronic denervation as a consequence of spinal neural compressive disease. The various mechanisms postulated for this distinct condition are outlined.
Las estrategias publicitarias de las marcas en el contexto de crisis
Authors: Fernández Blanco Elena , Alameda García David , Martín Martín Irene 
Published: January 2012

La crisis económica ha evidenciado una situación que venía aconteciendo en la comunicación estratégica desde hace años: el debilitamiento del modelo publicitario establecido. Las organizaciones se enfrentan a una pérdida progresiva de la eficacia comunicativa de la publicidad; a la dificultad de conectar emocionalmente con sus consumidores; al retroceso de los medios convencionales; a la explosión de la era de las relaciones personales y a la hegemonía de un ciudadano, proactivo y crítico, que replantea el propio concepto de comunicación. Todo este contexto hace que las empresas y organizaciones redefinan sus estrategias publicitarias, modificando objetivos, públicos, valores, lenguajes, medios y modos de contactar con sus públicos. El objetivo de este artículo es el estudio de las principales opciones estratégicas publicitarias que están desarrollando las organizaciones para sus marcas en el actual contexto de crisis. Para ello, se aborda el análisis de la estrategia publicitaria de una muestra significativa de los principales anunciantes del panorama nacional, representando a diferentes sectores de consumo. Mediante el análisis de contenido, combinado con análisis del discurso de las estrategias publicitarias de las principales marcas, procedemos al establecimiento de variables de análisis y a la categorización de los objetivos, estrategias, acciones y construcciones discursivas que las marcas desarrollan en sus políticas de comunicación. Los resultados de la investigación permiten concluir que las marcas están apostando por cuatro principales tipos de estrategias publicitarias: la estrategia de construcción de las U-brands, la defensa del valor de la marca tradicional, la estrategia centrada en el precio como principal argumento y la estrategia ofensiva de las marcas de distribuidor en torno a la calidad.
Escenarios y retos de la televisión pública en España
Authors: Manfredi Sánchez Juan Luis 
Published: January 2012

La televisión pública en España se enfrenta al reto de adaptarse y adecuarse a la expansión y la consolidación de los medios digitales globales. No se han acordado soluciones estables a las contradicciones del control editorial, la gestión económica, los contenidos y el buen gobierno corporativo, lo que dificulta la determinación de la misión de la televisión pública y las estrategias a seguir. La modernización del ordenamiento legal, la autonomía de los servicios informativos y la gestión de los canales digitales son avances positivos. No obstante, son continuistas, porque no parecen ligados de un proyecto común, con vocación de estabilidad. La financiación sigue siendo un asunto espinoso. La libertad que promueve la Comisión Europea en la definición del servicio público audiovisual degenera, en el caso español, en la indefinición sobre los contenidos y los medios de pago. La nueva autoridad audiovisual está llamada a liderar estas cuestiones y establecer parámetros homogéneos con el entorno europeo. Ha comenzado un nuevo proyecto que tendrá que establecer las bases de la misión, la dinámica y el alcance de RTVE y, por extensión, de los operadores autonómicos. Ha llegado el momento de pensar hacia dónde queremos encaminar la televisión pública en los próximos diez años.
Modelos de clivaje público-privado de la televisión subnacional en España
Authors: Badillo Matos Ángel 
Published: January 2012

El objeto de este trabajo es revisar el desarrollo de todas las formas de televisión subnacional que coexisten en España en un momento en el que la práctica totalidad de las comunidades autónomas ha resuelto ya sus concursos territoriales regionales, insulares y locales. A partir del estudio de las transformaciones del sistema audiovisual español en torno a los procesos de descentralización y desregulación, se revisa el impacto de la regulación en materia de televisión digital terrestre (TDT) en la transformación del tejido televisivo llamado en ocasiones local o de proximidad. En cada una de las comunidades autónomas se estudia el estado actual del audiovisual subnacional: televisiones locales, autonómicas, insulares, todas ellas además en sus variantes públicas y privadas. A partir de este análisis sistemático del estado de las políticas públicas estatales y autonómicas, se proponen cuatro modelos de clivaje entre operadores públicos y privados, para cuya elaboración se contemplan el número de operadores e indicadores de concentración comercial de licencias y mercados de audiencia potencial: los dominante público, dominante privado, plural fragmentado y plural concentrado.
Level Set Photonic Quasicrystals with Phase Parameters
Authors: Jia Lin , Bita Ion , Thomas Edwin L. 
Published: January 2012

AbstractA systematic study of the photonic band gap (PBG) properties of 8‐, 10‐ and 12‐fold rotational symmetric quasicrystals (QCs) defined by level set equations with various phase parameters is reported. The optimized filling ratios corresponding to the largest PBGs for 19 types of QCs are found, which are useful for photonic QC fabrication design. The impact of filling ratio, rotational symmetry, and experimental fabrication parameters on the resultant PBGs are studied via PBG maps calculated by finite‐difference time‐domain (FDTD). Large area, high quality 8‐, 10‐, and 12‐fold quasicrystalline pattern fabrication using multiple exposure interference lithography (MEIL) is also demonstrated.
Regulation of murine sinonasal cilia function by microbial secreted factors
Authors: Shen Jessica C. , Cope Emily , Chen Bei , Leid Jeff G. , Cohen Noam A. 
Published: January 2012

AbstractBackground:Chronic rhinosinusitis is a multifactorial disease resulting in impaired mucociliary clearance. Recent literature suggests that different bacterial species are associated with varied disease severity. We examined the immediate effect of microbial secreted factors on sinonasal ciliary function.Methods:Murine primary sinonasal cultures were established in an air‐liquid interface (ALI). Bacterial supernatants were isolated from H. influenza, S. pneumoniae, S. aureus, and P. aeruginosa cultures, as well as co‐cultures of H. influenza/S. pneumoniae and S. aureus/P. aeruginosa. Controlling for pH and osmolarity, supernatants were administered at 50% concentration to the apical surface of the ALI culture. Basal ciliary beat frequency (CBF) was recorded for 20 minutes, at 5‐minute intervals. Control groups were treated with culture broth. At minimum, experiments were performed in triplicate. Stimulated CBF was recorded after mechanical stimulation via short bursts of pressurized air (55 mmHg).Results:All supernatants reduced basal CBF. S. pneumoniae and P. aeruginosa caused significant reduction in CBF at all time points, with the largest decrease of −46.3 ± 1.6% (p < 0.001) for S. pneumoniae and −27.1 ± 2.8% (p < 0.001) for P. aeruginosa. S. aureus caused the basal CBF to decline by −33.0 ± 2.8% (p < 0.001) at 5 minutes, which reversed by 20 minutes. Overall, H. influenza yielded the least change in CBF (−20.0 ± 2.8%, p < 0.002). Co‐cultures (H. influenza/S. pneumoniae and S. aureus/P. aeruginosa) resulted in delayed CBF reduction compared with monocultures. P. aeruginosa also blunted stimulated CBF (p < 0.02).Conclusion:Results demonstrated acute decreases in murine sinonasal CBF after exposure to bacterial supernatants. Moreover, P. aeruginosa resulted in diminished ciliary stimulation capacity. © 2012 ARS‐AAOA, LLC.
Effect of a dexamethasone Sinu‐FoamTM middle meatal spacer on endoscopic sinus surgery outcomes: A randomized, double‐blind, placebo‐controlled trial
Authors: Rudmik Luke , Mace Jess , Mechor Brad 
Published: January 2012

AbstractBackground:Off‐label drug eluting middle‐meatal spacers have shown promising results for improving clinical outcomes following endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). This study evaluates a dexamethasone Sinu‐FoamTM spacer following ESS for CRS without nasal polyposis (CRSsNP).Methods:Patients with CRSsNP (n = 36) were enrolled into a double‐blind, placebo‐controlled trial and randomized into either a treatment arm (dexamethasone Sinu‐FoamTM mixture; n = 18) or placebo arm (Sinu‐FoamTM alone; n = 18). Therapeutic outcomes were evaluated at 1 week, 4 weeks, and 3 months using sinonasal endoscopy and graded using the Lund‐Kennedy scoring system. Postoperative care included nasal saline irrigations and a short course of systemic steroids.Results:All patients completed the study follow‐up period. Both study arms experienced significant improvement in endoscopic grading over the study duration (p < 0.001). There was no difference in average endoscopic scores between the treatment and placebo groups at 1 week, 4 weeks, and 3 months (all p > 0.489).Conclusion:This study demonstrated that an off‐label drug‐eluting middle‐meatal spacer of dexamethasone and Sinu‐FoamTM does not improve endoscopic outcomes in the early postoperative period following ESS when combined with postoperative saline irrigations and a short course of systemic steroids. © 2011 ARS‐AAOA, LLC.
A comparative study of mouse nasal septal and turbinal epithelium for in vitro cell cultures
Authors: Jiao Jian , Wang Hong , Jin Shanzhe , Fan Erzhong , Li Ying , Han Demin , Zhang Luo 
Published: January 2012

AbstractBackground:The small number of epithelial cells that can be isolated from mouse respiratory tract has limited its application to study of the airway. Our purpose in this work was to compare the potential of mouse nasal septal and turbinal epithelium for serving as a cell source for in vitro cell cultures.Methods:The distribution of ciliated epithelial cells in the mouse nasal cavity, and the surface area of the respiratory epithelium in the mouse nasal septum and turbinate were determined by β‐tubulin IV immunohistochemistry. Ciliated epithelial cell density of native mouse nasal septum and turbinate, and the morphology of cultured mouse nasal septal and turbinal epithelial cells were examined by scanning electron microscopy (SEM) and β‐tubulin IV and zona occludens (ZO)‐1 dual‐label fluorescent cytochemistry, respectively. Cilia reactivity to exogenous stimuli (adenosine triphosphate or benzalkonium chloride) in cultured nasal septal and turbinal epithelial cells was studied using high‐speed digital microscopy.Results:The ciliated epithelial cell density of native nasal epithelium, the morphology and cell yield of in vitro cultured epithelial cells, and cilia reactivity to exogenous stimuli of mouse turbinate are comparable to that of the nasal septum. However, the respiratory epithelium surface area of mouse turbinate is significantly larger than that of the nasal septum.Conclusion:Mouse turbinate may also serve as an ideal source of in vitro epithelial cell cultures. Both nasal septum and turbinate should be harvested to optimize animal use in the establishment of primary murine respiratory epithelial cultures. © 2012 ARS‐AAOA, LLC.