bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cartilage and Bone Biomarkers in Rheumatoid Arthritis: Prediction of 10-year Radiographic Progression
Authors: SYVERSEN SILJE W. , GOLL GURO L. , van der HEIJDE DÉSIRÉE , LANDEWÉ ROBERT , GAARDER PER IVAR , ØDEGÅRD SIGRID , HAAVARDSHOLM ESPEN A. , KVIEN TORE K. 
Published: May 2009

Objective.As current predictors of joint destruction have low specificity, serological biomarkers reflecting bone and cartilage destruction have been proposed as tools in assessing prognosis of rheumatoid arthritis (RA). We examined whether serum concentrations of a panel of biomarkers could predict radiographic progression in patients with RA.Methods.A cohort of 238 patients with RA was followed longitudinally for 10 years with collection of clinical data and serum samples. These analyses focus on the 136 patients with radiographs of the hands available at baseline and at 5 and/or 10 years. Radiographs were scored according to the van der Heijde-modified Sharp score (SHS). Baseline sera were analyzed for receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin (OPG), human cartilage glycoprotein-39 (YKL-40), C2C, collagen cross-linked C-telopeptide (CTX-I), and cartilage oligomeric matrix protein (COMP). Multivariate linear and logistic regression analyses were used to identify predictors of radiographic progression.Results.Baseline CTX-I levels were higher in progressors [0.41 ng/ml (interquartile range 0.31–0.75)] than in nonprogressors [0.32 ng/ml (IQR 0.21–0.49)], and were independently associated with 10-year change in radiographic damage score [ß = 16.4 (IQR 5.7–27.1)]. We found no association between radiographic progression and baseline serum levels of RANKL, OPG, C2C, YKL-40, or COMP.Conclusion.This longterm followup study of patients with RA indicates a relationship between elevated CTX-I levels in serum and subsequent joint destruction. This association was, however, weak, and our study does not support that serum CTX-I or any of the other tested biomarkers will serve as more useful prognostic markers than current predictors such as anti-cyclic citrullinated peptide, radiographic damage early in the disease course, and signs of inflammation.
Time Trends in Epidemiology and Characteristics of Psoriatic Arthritis Over 3 Decades: A Population-based Study
Authors: WILSON FLORANNE C. , ICEN MURAT , CROWSON CYNTHIA S. , McEVOY MARIAN T. , GABRIEL SHERINE E. , KREMERS HILAL MARADIT 
Published: May 2009

Objective.To determine time trends in incidence, prevalence, and clinical characteristics of psoriatic arthritis (PsA) over a 30-year period.Methods.We identified a population-based incidence cohort of subjects aged 18 years or over who fulfilled ClASsification of Psoriatic ARthritis (CASPAR) criteria for PsA between January 1, 1970, and December 31, 1999, in Olmsted County, Minnesota, USA. PsA incidence date was defined as the diagnosis date of those who fulfilled CASPAR criteria. Age- and sex-specific incidence rates were estimated and age- and sex-adjusted to the 2000 US White population.Results.The PsA incidence cohort comprised 147 adult subjects with a mean age of 42.7 years, and 61% were men. The overall age- and sex-adjusted annual incidence of PsA per 100,000 was 7.2 [95% confidence interval (CI) 6.0, 8.4] with a higher incidence in men (9.1, 95% CI 7.1, 11.0) than women (5.4, 95% CI 4.0, 6.9). The age- and sex-adjusted incidence of PsA per 100,000 increased from 3.6 (95% CI 2.0, 5.2) between 1970 and 1979 to 9.8 (95% CI 7.7, 11.9) between 1990 and 2000 (p for trend < 0.001). The point prevalence per 100,000 was 158 (95% CI 132, 185) in 2000, with a higher prevalence in men (193, 95% CI 150, 237) than women (127, 95% CI 94, 160). At incidence, most PsA subjects had oligoarticular involvement (49%) with enthesopathy (29%).Conclusion.The incidence of PsA has been rising over 30 years in men and women. Reasons for the increase are unknown, but may be related to a true change in incidence or greater physician awareness of the diagnosis.
Making a link between childhood physical abuse and cancer
Authors: Fuller‐Thomson Esme , Brennenstuhl Sarah 
Published: May 2009

AbstractBACKGROUND:Abuse in childhood is associated with many negative adult health outcomes. Only 1 study to date has found an association between childhood abuse and cancer. By using a regionally representative community sample, this preliminary study sought to investigate the association between childhood physical abuse and cancer while controlling for 3 clusters of risk factors: childhood stressors, adult health behaviors, and adult socioeconomic status.METHODS:Regional data from the Canadian provinces of Manitoba and Saskatchewan were selected from the 2005 Canadian Community Health Survey. Of the 13,092 respondents, 7.4% (n = 1025) reported that they had been physically abused as a child by someone close to them, and 5.7% (95% confidence interval [CI], 4.9‐6.6) reported that they had been diagnosed with cancer by a health professional. The regional level response rate was 84%.RESULTS:Childhood physical abuse was associated with 49% higher odds (95% CI, 1.10‐2.01) of cancer when adjusting for age, sex, and race only. The odds ratio decreased only slightly to 47% higher odds (95% CI, 1.05‐1.99) when the model was adjusted for all 3 clusters of risk factors.CONCLUSIONS:A significant and highly stable association between childhood physical abuse and cancer was found even when adjusting for 3 clusters of risk factors. Further research focusing on the potential mechanisms linking childhood abuse and cancer is needed. Cancer 2009. © 2009 American Cancer Society.
The cancer Support Person's Unmet Needs Survey
Authors: Campbell H. Sharon , Sanson‐Fisher Rob , Taylor‐Brown Jill , Hayward Lynda , Wang X. Sunny , Turner Donna 
Published: May 2009

AbstractBACKGROUND:A rigorous psychometric methodology was used to develop a measure of unmet needs for cancer survivors' principal support persons. Principal support person was defined as “someone you can count on and who helps you with your needs.”METHODS:Development of the domains and the items followed an extensive literature review, iterative input from support persons, and consultation with health professionals and front‐line staff working with cancer survivors and their supports. Cognitive interviews helped clarify item wording, and the draft questionnaire was reappraised by a group of support persons. The questionnaire was reduced to 90 items and sent to a stratified, random sample of cancer survivors selected from a provincial population‐based cancer registry. They were asked to give the survey to their support person.RESULTS:The resulting 78‐item Support Person Unmet Needs Survey has high acceptability, item test‐retest reliability, internal consistency (Chronbach alpha = .990), and face, content, and construct validity. It captures 6 domains of unmet needs and accounts for 73.5% of total variance: Information and Relationship Needs (27 items, 22.1% of variance), Emotional Needs (16 items, 15.2%), Personal Needs (14 items, 14.0%), Work and Finance (8 items, 8.8%), Health Care Access and Continuity (9 items, 8.6%), and Worries About Future (4 items, 4.8%).CONCLUSIONS:This instrument will be of use where there is an interest in examining the impact of cancer not only on cancer survivors but also on their identified principal support persons. Cancer 2009. © 2009 American Cancer Society.
Formyl‐Porphyrin and Formyl‐Fullerenoporphyrin Building Blocks for the Construction of Multiporphyrin Arrays
Authors: Urbani Maxence , Iehl Julien , Osinska Iwona , Louis Rémy , Holler Michel , Nierengarten Jean‐François 
Published: May 2009

AbstractA fullerene derivative bearing a benzaldehyde unit has been prepared and used as starting material for the synthesis of a formyl‐fullerenoporphyrin building block. Condensation of this aldehyde with pyrrole in CHCl3 with BF3·Et2O as catalyst followed by p‐chloranil oxidation yielded a pentaporphyrinic scaffold surrounded by four peripheral C60 subunits. By following a similar strategy, a bis‐porphyrin building block bearing an aldehyde function was prepared and used for the construction of a nonaporphyrin array by reaction with pyrrole under typical porphyrin synthesis conditions. Whereas the 1H NMR spectrum recorded at room temperature for the nonaporphyrin system is well defined, the signals recorded under the same conditions for the pentaporphyrin derivative surrounded by four peripheral C60 groups are broad. Indeed, the C60‐pentaporphyrin ensemble appears as a mixture of conformers which equilibrate slowly on the NMR time scale at room temperature.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
A 14th–17th century osteoporotic hip fracture from the Santa Clara‐a‐Velha Convent in Coimbra (Portugal)
Authors: Curate F. , Lopes C. , Cunha E. 
Published: May 2009

AbstractOsteoporosis is an evocative term for a metabolic disorder characterized by loss of bone mass and organization, which predisposes to fracture. The clinical consequences of osteoporosis lie in the problems associated with it, specifically hip, Colles and vertebral fractures. We present here an extracapsular fracture of the proximal femur in an aged female skeleton from the Santa Clara‐a‐Velha Monastery (14th–17th centuries) in Coimbra, Portugal. This fracture is probably secondary to an osteoporotic disorder. Bone remodeling at the fracture site confirms that this woman survived for a long period after sustaining a fracture of the proximal femur, suggestive of a solid community assistance and support. Copyright © 2009 John Wiley & Sons, Ltd.
Ancient DNA (aDNA) studies of man and microbes: general similarities, specific differences
Authors: Taylor G. M. , Mays S. A. , Huggett J. F. 
Published: May 2009

AbstractThe study of ancient DNA (aDNA) using molecular methods is an increasingly valuable tactic in bioarchaeology. While this method must be carefully undertaken to ensure that the molecules detected are representative of the ancient sample and not modern contaminates, there is a danger that a ‘one size fits all’ approach to validation will lead to misinterpretation and/or missed opportunities of valuable findings. When comparing human and pathogen aDNA, there are many shared technical means that can ensure best practice. However, there are a number of assumptions that should not be used for both scenarios. We discuss these aspects in reference to a recent article published by this journal and highlight some of the latest advances in molecular detection of ancient pathogen DNA that can further improve this endeavour. Copyright © 2009 John Wiley & Sons, Ltd.
Flammability and thermal degradation of epoxy acrylate modified with phosphorus‐containing compounds
Authors: Chen Xilei , Jiao Chuanmei 
Published: May 2009

AbstractA series of UV‐curable flame retardant resins was obtained using epoxy acrylate (EA) modified with 1‐oxo‐4‐hydroxymethyl‐2,6,7‐trioxa‐1‐phosphabicyclo[2.2.2]octane (PEPA). The flammability was characterized by limiting the oxygen index (LOI), UL 94 and cone calorimeter, and the thermal degradation of the flame retardant resins was studied using thermogravimetric analysis (TGA) and real time Fourier transform infrared (RTFTIR). The results indicated that the flame retardant efficiency increases and the heat release rate (HRR) decreases greatly with the content of PEPA. The TG data showed that the modified epoxy acrylates (MEAs) have lower initial decomposition temperatures and higher char residues than pure EA. The RTFTIR study indicates that the MEAs have lower thermal oxidative stability than the pure EA. Copyright © 2009 John Wiley & Sons, Ltd.
Securing a sustainable future through a new global contract between rich and poor
Authors: de Lange Willem J. , Wise Russell M. , Nahman Anton 
Published: May 2009

AbstractGlobal sustainable development depends on the capacity of natural, social and economic systems to adapt to external stimuli. However, building this adaptive capacity in the developing world context of sub‐Saharan Africa will require substantial investment in these systems, which most countries in this region simply cannot afford. Given that their social, economic and environmental security depends on developments in developing countries, we argue that developed countries should assume a leading role in making such investments in developing countries, in order to secure their own long‐term well‐being. This will require cooperative governance between developed and developing countries, and targeted investment in a number of key areas. This calls for a new global contract between rich and poor nations in order to achieve global stability and sustainability. Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment.
The social dimension of sustainable development: Defining urban social sustainability
Authors: Dempsey Nicola , Bramley Glen , Power Sinéad , Brown Caroline 
Published: May 2009

AbstractSustainable development is a widely used term, which has been increasingly influential on UK planning, housing and urban policy in recent years. Debates about sustainability no longer consider sustainability solely as an environmental concern, but also incorporate economic and social dimensions. However, while a social dimension to sustainability is widely accepted, exactly what this means has not been very clearly defined or agreed. This paper aims to address this disparity through a detailed exploration and definition of the concept of social sustainability within the urban context. The relationship between urban form and social sustainability is explored and two main dimensions of social sustainability are identified and discussed in detail: equitable access and the sustainability of the community itself. Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment.
Two Hybrid Compounds Constructed from Vanadate Clusters and Secondary Metal‐Bis(imidazole) Subunits
Authors: Wang Xiuli , Hu Hailiang , Chen Baokuan , Lin Hongyan , Liu Guocheng , Li Jin 
Published: May 2009

AbstractTwo new inorganic–organic vanadate hybrid compounds [Mn(Hbbi)2(V4O12)] (1) and [Cd(Hbbi)2(V4O12)] (2) (bbi = 1,1’‐(1,4‐butanediyl)bis(imidazole)) were hydrothermally synthesized and characterized by elemental analyses, IR spectroscopy, TG and single‐crystal X‐ray diffraction. The two compounds crystallize in monoclinic system, P21/c space group with a = 8.556(5) Å, b = 10.761(5) Å, c = 16.917(5) Å, β = 93.032(5) o, V = 1555.4(12) Å3, Z = 2, R = 0.0390 for 1 and a = 8.657(5) Å, b = 10.743 (5) Å, c = 16.864 (5) Å, β = 93.81(5)o, V = 1564.9 (12) Å3, Z = 2, R = 0.0717 for 2. Single‐crystal X‐ray diffraction analysis reveals that the two compounds are isostructural and both consist of one‐dimensional (1D) chains, which are constructed from vanadate anion clusters and [M(Hbbi)2]4+ cation groups [M = MnII (1), CdII (2)]. Moreover, the polymeric chains are ultimately packed into a three‐dimensional (3D) supramolecular framework through C–H···O and N–H···O hydrogen bonding interactions.
Supramolecular Structures with the 2‐Propyl‐4,5‐dicarboxy‐1H‐imidazole Ligand: Hydrothermal Synthesis, Structures, and Photoluminescence
Authors: Li Xiao‐Xu , Wang Ning , Yue Shan‐Tang , Li Zhao‐Yang , Wu Hong‐Yan , Liu Ying‐Liang 
Published: May 2009

AbstractSelf‐assembly of the rigid organic ligand 2‐propyl‐4,5‐dicarboxy‐1H‐imidazole (L) with different metal ions (Zn2+, Ni2+, Cu2+, Cd2+) led to four new complexes, namely, [M(L)(phen)] [M = Zn (1); Ni (2); Cd (3)] and [Cu(L)(4)] (phen = 1,10‐phenanthroline). Their structures were determined by single‐crystal X‐ray diffraction analyses, and they were further characterized by elemental analysis, IR spectroscopy, and thermogravimetric analysis. Whereas compounds 1, 2, and 3 are discrete units, hydrogen‐bonding interactions play a vital role in these complexes. Compounds 1 and 2 form one‐dimensional (1D) and two‐dimensional (2D) structures through hydrogen‐bondinginteractions with helical character. In 1, the hydrogen bonds (O–H···O) alternately bridge the MII cations of the discrete units to form a one‐dimensional (1D) infinite helical chain. Complex 2 forms a 2D helical layer through parallel hydrogen bonds (N/O–H···O/N) between two adjacent helical chains. In 3, the hydrogen bonds (N–H···O) connect adjacent discrete units into a ten‐membered ring with extension into a one‐dimensional double‐chain supramolecular structure. Complex 4 is a two‐dimensional gridlike (4,4) topological layer which is extended to a 3D network by hydrogen bonding. The solid‐state fluorescence spectrum of complex 3 was determined.
Depression, anxiety, health‐related quality of life and pain in patients with chronic fibromyalgia and neuropathic pain
Authors: Gormsen Lise , Rosenberg Raben , Bach Flemming W. , Jensen Troels S. 
Published: May 2009

AbstractChronic pain is often associated with comorbidities such as anxiety and depression, resulting in a low health‐related quality of life. The mechanisms underlying this association are not clear, but a disturbance in the pain control systems from the brain stem has been suggested. Thirty neuropathic pain (NP) patients, 28 patients with fibromyalgia (FM), and 26 pain‐free age‐ and gender‐matched controls were included and examined with respect to mental distress (self‐rated Symptom Checklist‐92), depression (doctor‐rated Hamilton Depression Scale and self‐rated Major Depression Inventory), and anxiety (doctor‐rated Hamilton Anxiety Scale and self‐rated Anxiety Inventory). In addition, patients assessed their health‐related quality of life (SF‐36). Chronic pain patients with FM and NP had significantly more mental distress including depression and anxiety than healthy controls both by self‐rating and by a professional rating. However, these scores are low compared to other studies on mental distress in chronic pain patients. Only few chronic pain patients meet the diagnostic criteria for depression (NP 3.3%, FM 7.1%), and associations between pain and mental symptoms were only found in the FM group despite similar pain intensities. The findings suggest that different mechanisms are responsible for the development of mood disorders in the two patient groups.
Word‐of‐mouth transmission in settings with multiple opinions: The impact of other opinions on WOM likelihood and valence
Authors: Ryu Gangseog , Han Jin K. 
Published: May 2009

AbstractScholars in social psychology and marketing have traditionally examined word‐of‐mouth (WOM) interactions in a dyadic setting, comprised of a WOM‐opinion provider and its recipient. Yet, social interactions also often occur in larger settings, and group‐based research has shown group sizes to affect its member behavior. To this end, we set out to examine WOM transmission in a larger context by introducing a WOM responder, whose role is to provide a second opinion to the WOM recipient. In Experiment 1, we find that social relations in the triad play a key role in WOM transmission. For strong ties, the WOM responder showed little difference in willingness to offer a second opinion irrespective of its congruency with the first opinion. Incongruency with the first opinion, however, reduced the valence of the second opinion. For weak ties, the presence (vs. absence) of first opinion—irrespective of its congruency—increased the likelihood of offering a second opinion and also its valence. We demonstrate that the effects could be attributable to different accessibility of needs for assimilation and differentiation as well as of motivational orientations toward other parties of WOM. Experiment 2 takes a closer look at the conflicting motivations of social influence (normative vs. informational) associated with strong ties, and finds both in operation but to a differing degree. Finally, a follow‐up study addresses the current findings in the context of satisfied/dissatisfied consumers.
Oesophageal foreign body and a double aortic arch: rare dual pathology
Authors: O'Connor T E , Cooney T 
Published: May 2009

AbstractObjective:We report the rare case of an oesophageal foreign body which lodged above the site of oesophageal compression by a double aortic arch.Methods:Case report and a review of the literature surrounding the classification, embryology, diagnosis and management of vascular rings and slings.Results:An eight-month-old male infant presented with symptoms of tracheal compression following ingestion of an oesophageal foreign body. Following removal of the oesophageal foreign body, the infant's symptoms improved initially. However, subsequent recurrence of respiratory symptoms lead to a repeat bronchoscopy and the diagnosis of a coexisting double aortic arch, causing tracheal and oesophageal compression.Conclusion:To our knowledge, this is only the second reported case of a double aortic arch being diagnosed in a patient following removal of an oesophageal foreign body.
Trialling an automated passive acoustic detector (T-POD) with Hector's dolphins (Cephalorhynchus hectori)
Authors: Rayment William , Dawson Steve , Slooten Liz 
Published: May 2009

Acoustic surveys can have several advantages over visual methods in surveys of cetaceans, although verification is required that novel techniques are effective. The T-POD is an autonomous acoustic data logger with inbuilt filters that can be set to match the click characteristics of the target species. We tested the performance of the T-POD for detecting Hector's dolphins at Flea Bay, Banks Peninsula, New Zealand. Simultaneous visual surveys were conducted from a hillside overlooking the bay, with distances between the T-POD and dolphins measured using a theodolite. Wideband sound recordings confirmed that T-POD detections were echolocation clicks made by Hector's dolphins. Detection probability and click train detection rate decreased with increasing distance, with no detections made beyond 500 m. By fitting detection functions to the probability of detection versus distance we showed that the T-POD effectively detected all dolphin groups within a radius of 198–239 m, depending on the click train categories utilized. The T-POD shows considerable promise as a tool for passive acoustic surveys of Hector's dolphins, with possible applications in studies of distribution, habitat use and echolocation behaviour.
First molecular estimate of sex-ratio of southern right whale calves, Eubalaena australis, for Brazilian waters
Authors: de Oliveira Larissa Rosa , Ott Paulo Henrique , Flores Paulo A.C. , Siciliano Salvatore , de Almeida Raquel Santos , Bonatto Sandro L. 
Published: May 2009

The southern right whale (Eubalaena australis) was one of the most intensively hunted whales between the 17th and 20th centuries in the southern hemisphere. Recent estimates indicate that today there are around 7000 whales, representing 5 to 10% of its original population. On the other hand, recent studies estimated that the population that migrates to the Brazilian coast grew by 14% from 1987 to 2003. However, there is no information about sex-ratio for adults or for calves in this region, which is an important parameter for understanding the biology of the species. We present here the first estimate of calves' sex-ratio of southern right whales found along the southern Brazilian coast, one of the most important wintering grounds for the species. Sex was molecularly indentified for 21 biopsies collected from calves between 1998 and 2002, along the coast of Rio Grande do Sul and Santa Catarina States, in southern Brazil. The sex-ratio was two females for one male, however, it was not statistically different (χ2 test, α = 0.05; df = 1) from the expected ratio of 1:1. This result is in accordance with the sex-ratio estimated for the species of all ages using external morphology (and behaviour information), as well as for most species of baleen whales.