bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRCN: Enhanced Coherence Mechanism forNear Memory Processing Architectures
Authors: Kabat Amit Kumar , Pandey Shubhang , Venkatesh TG 
Published: June 2024

Abstract

In Near Memory Processing (NMP), processing elements(PEs) are placed near the 3D memory, reducing unnecessary data transfers between the CPU and the memory. However, as the CPUs and the PEs of the NMP use a shared memory space, maintaining coherency between them is a challenge. Most current literature relies on maintaining coherence for fine-grained or coarse-grained instruction granularities for the offloaded code blocks. We understand that for most NMP-offloaded instructions, the coherence conflict is low, and waiting for the coherence transaction hinders the performance. We construct an analytical model for an existing coherence strategy called CONDA, which is within 4% accuracy. This model indicates the key parameters responsible - the granularity of offloaded code, probability of conflicts, transaction times, and commit time. This paper identifies the prospective optimizations using the analytical model for CONDA. It proposes a new coherence scheme called MRCN: Monitored Rollback Coherence for NMP. MRCN addresses the coherence issue while eliminating unnecessary re-executions with limited hardware overhead. The MRCN is evaluated on synthetic as well as Rodinia benchmarks. The analytical results are within 4% accuracy of the simulation results. The MRCN shows improvement of up to 25% over CONDA strategy for the same benchmark under different execution conditions.
Memory B cell responses induced by pneumococcal conjugate vaccine schedules with fewer doses: analysis of a randomised-controlled trial in Viet Nam
Authors: Ong Darren , Thanh Phan Van , Temple Beth , Toh Zheng Quan , Nguyen Cattram , Vientrung Kien , Nguyen Hoang Van Anh , Dai  Vo Thi Trang , Bright Kathryn , Tran Hau Phuc , Higgins Rachel , Cheung Yin Bun , Nguyen Thuong , Mulholland Kim , Licciardi Paul 
Published: June 2024

Abstract

The use of pneumococcal conjugate vaccine (PCV) schedules with fewer doses are being considered to reduce costs and improve access, particularly in low- and middle-income countries. While several studies have assessed their immunogenicity, there are limited data on their potential for long-term immune protection, as assessed by pneumococcal serotype-specific memory B cell (Bmem) responses. This study aimed to compare Bmem responses following reduced-dose (0 + 1 and 1 + 1) schedules of PCV10 and PCV13 in Vietnamese infants from our randomised-controlled trial. Following vaccination at 12 months of age, Bmem levels for most serotypes peaked seven days post-vaccination and were higher in magnitude for the 1 + 1 than 0 + 1 schedules and for PCV13 than PCV10. Furthermore, Bmem did not wane as rapidly as IgG levels by 24 months of age. Further studies are needed to assess the use of Bmem as markers of long-term protection against pneumococcal carriage and disease, which is crucial to generate data for immunisation program decision-making.
Application of Adherence Scale and WeChat-based Continuing Nursing to Improve the Therapeutic Efficacy of Peg-IFN in CHB Patients
Authors: Qin Yanghua 
Published: June 2024

Abstract

Objective: To explore the effects of applying the eight-item Morisky Adherence Scale (MMAS-8) combined with WeChat-based continuing nursing on improving adherence and immunological response in patients with chronic hepatitis B (CHB) undergoing pegylated interferon (Peg-IFN) therapy.
Methods: A total of 156 patients diagnosed with chronic hepatitis B and initiating Peg-IFN treatment in our outpatient department from January to December 2018, who returned for follow-up after 12 weeks of treatment, were included in the study. Based on MMAS-8 evaluation results, patients were categorized into high-adherence and low-adherence groups. The high-adherence group received routine education and nursing, while the low-adherence group received WeChat-based continuing nursing. Adherence was reassessed using MMAS-8 after 48 weeks of treatment, and Peg-IFN treatment's immunological response was assessed based on laboratory indicators.
Results: Compared with baseline, at 12 weeks of treatment, the high-adherence group exhibited an immunological response rate of 44.9% (35/78), whereas the low-adherence group had a response rate of only 30.8% (24/78), showing a statistically significant difference between the groups (p<0.05, Fisher's exact test). By the 48th week of treatment with WeChat-based continuing nursing, the MMAS-8 scores were 7.0±0.6 and 7.1±0.6 in the high-adherence and low-adherence groups, respectively, with no statistically significant difference (p=0.20). There were no significant differences between the groups in immunological response rate, HBeAg seroconversion rate, or clinical cure rate.
Conclusion: In the outpatient treatment of chronic hepatitis B with Peg-IFN, the application of the adherence scale combined with WeChat-based continuing nursing not only improves patient adherence but also enhances clinical treatment outcomes.
Practice implications: Using classical scales and new media tools can help outpatient care providers deliver better care services and improve the treatment outcomes for chronic diseases.
Cerebrovascular burden and its association with Ménière’s disease: a case-control study
Authors: de Sousa Francisco Alves , Tarrio João , Moreira Bruno , Pinto Ana Nóbrega , Meireles Luís , Rego Ângela 
Published: June 2024

Abstract

Purpose No universally accepted model describes Ménière´s disease (MD) pathogenesis. Nevertheless, the vascular hypothesis for MD has recently been revisited. The objective was to compare the cerebrovascular burden of MD patients with controls.Methods Patients were evaluated concerning magnetic resonance imaging (MRI) features of small-vessel disease (SVD), cortical strokes and baseline comorbidities. Analyses were performed comparing MD and age-matched controls.Results A total of 145 patients were enrolled (70 MD and 75 controls). The MD group showed higher mean SVD scores (SVD-3: 0.56 ± 0.9 in MD vs 0.29 ± 0.6 in controls, p = 0.041; SVD-3 low-Fazekas: 1.10 ± 0.8 in MD vs 0.71 ± 0.7 in controls, p = 0.002; SVD-3 low-EPVS: 1.21 ± 0.9 in MD vs 0.76 ± 0.8 in controls, p = 0.002; SVD-3 low-Fazekas + low-EPVS : 1.79 ± 0.9 in MD vs 1.21 ± 0.9 in controls, p < 0.001). This association persisted after confounder adjustment for age, sex and comorbidities (OR:1.746, p = 0.045 for SVD-3; OR:2.495, p = 0.002 for SVD-3 low-Fazekas; OR: 2.234, p = 0.001 for SVD-3 low-EPVS; OR: 2.428, p < 0.001 for SVD-3 low-Fazekas low-EPVS). Neither the presence of cortical strokes (10% in MD vs 4% in controls, p = 0.154) nor comorbidities significantly differ between groups (p > 0.05).Conclusions This is the first study to compare MD with controls according to cerebrovascular burden. Cerebrovascular dysfunction may influence the incidence of MD. Further studies supporting the relationship of cerebrovascular disease with MD are needed.
Psychometric Properties of an Arabic Translation of the older people’s quality of life-brief (OPQOL-brief) scale.
Authors: Khalil Marwa Ibrahim Mahfouz , Hallit Souheil , Fekih-Romdhane Feten , Bitar Zeinab , Shaala Reem Said , Mousa Enas Fouad Sayed , Menessy Reem Farag Mahrous , Elnakeeb Mayar 
Published: June 2024

Abstract

Background:This investigation was undertaken to scrutinize the psychometric qualities of the Arabic Older People's Quality of Life-Brief (OPQOL-brief) scale.Method:A suitable sample of 539 Arabic-speaking older Egyptians—of whom 50.3% were female and 60.7% were aged 65-75 years—were included in the cross-sectional examination.Results:Confirmatory factor analysis validated the goodness-of-fit, which shows that the scale's items accurately measure the desired attributes. The reliability assessments revealed a high degree of internal consistency in the overall score, with Cronbach's alpha and McDonald's omega values of .92. Male and female participants did not significantly differ in the measurement features, as indicated by gender invariance tests. The study of concurrent validity demonstrated a strong positive correlation (r=.60, p<.001) between the Arabic OPQOL-brief scale and resilience scores.Conclusion:This research closes a gap in the literature by demonstrating the psychometric qualities of the Arabic OPQOL-brief scale, which is a crucial tool for measuring the quality of life in this group. The results strengthen the validity and reliability of the scale as a means of evaluating the quality of life of older individuals who speak Arabic, hence increasing its suitability for application in a variety of research and therapeutic contexts.
Prevalence of child malocclusion and its association with time of breastfeeding and/or deleterial habits in children from 2 to 6 years old at public schools in Bento Gonçalves, Rio Grande do Sul, Brazil – pilot project
Authors: De Bacco Giovana , Schenato Juliana , Valério Patrícia 
Published: June 2024

Knowing that the worldwide prevalence of malocclusion in early childhood is 54 %, we carried out a pilot project in the first half of 2022 at Public Schools in Bento Gonçalves RS, evaluating 1938 children between 2 and 6 years old. The prevalence of malocclusion found was 23 %. Anterior open bite, whether or not accompanied by posterior crossbite, was the most prevalent malocclusion. About 70 % of the children were not breastfed or breastfed for less than 6 months, presenting a non-nutritive sucking habit. Assessing 5 years old children alone, this prevalence rose to 54 %. The results reinforce the need of public health policies that promote and support prolonged breastfeeding, which expand the knowledge of parents or guardians and school staff about the adverse effects caused by the use of pacifiers and baby bottles, with the adoption of transdisciplinary measures for the prevention, interception and treatment of malocclusions in a timely manner.
Relación entre indicadores objetivos y subjetivos de la clase social desde una perspectiva psicológica
Authors: Correa Pablo , Brussino Silvina , Reyna Cecilia 
Published: June 2024

En las últimas décadas, ha crecido el interés en el campo de la Psicología Social sobre los aspectos objetivos y subjetivos de la clase social y su asociación con otras variables psico-sociales. Así, en este trabajo nos propusimos analizar la relación entre el nivel socioeconómico (NSE), indicadores singulares del NSE (nivel educativo y ocupación), el nivel de ingresos familiares y el estatus social subjetivo (ESS), e indagar las diferencias en el ESS según el género, en una muestra de 442 ciudadanos del Gran Córdoba, Argentina de 18 a 64 años (M = 38.61, DE = 14.23). Mediante un estudio de tipo transversal, ex post facto retrospectivo, se condujeron análisis descriptivos, de asociación entre variables, de regresión y de comparación de grupos. Los resultados evidenciaron que, independientemente de su NSE, las personas percibieron tener un ESS medio (79%). Además, hallamos que la relación entre el NSE, el nivel de ingresos familiares, el nivel educativo, el tipo de ocupación con el ESS es estadísticamente significativa. En cuanto al modelo de regresión, el nivel de ingresos resultó ser el único indicador que se relacionó con el ESS. También, encontramos que las mujeres con un NSE bajo (Mdn = 5.00, R = 6.00) percibieron tener un ESS más elevado que los varones con NSE bajo (Mdn = 4.00, R = 6.00). En conclusión, las personas tienden a posicionarse en los niveles medios de la escala de MacArthur aun cuando su condición socioeconómica objetiva no refleja esa posición. Además, las mujeres con un NSE bajo tienden a posicionarse en niveles más altos en la escala de MacArthur que los varones con NSE bajo.
Microsprinkler irrigation in combination with nutrient management influences crop and water productivity and water-nutrient dynamics in large cardamom-growing soils in the hilly sub-Himalayan region of India
Authors: Lepcha Rodrick , Patra Sanmay Kumar , Poddar Ratneswar , Sarkar Arindam , Ray Ratneswar , Alharbi Sulaiman Ali , Ansari Mohammad Javed , Hossain Akbar 
Published: June 2024

ABSTRACT

A field experiment designed with three tiers of irrigation viz., I0: rainfed, I1: 100% crop evapotranspiration (1.0 ETc) and I2: 0.75 ETc and four tiers of soil nutrition viz., N0: control (no farmyard manure and fertilizer), N1: 100% recommended dose of fertilizer (RDF) as FYM, N2: 50% RDF as FYM +50% RDF as chemical fertilizers and N3: 100% RDF as chemical fertilizers was conducted for four consecutive years (2015–2018) on large cardamom at the hilly terrain of Gitdubling lower beyong busty in Kalimpong Block II in Darjeeling district of WB India. The results showed that I1N3 treatment combination providing microsprinkler irrigation at 1.0 ETc and full RDF (20:40:40::N:P2O5:K2O kg ha−1) recorded highest growth, yield attributes, fresh yield (665.2 kg ha−1) and dry yield (282.0 kg ha−1) of capsules, greatest water productivity (1.8 × 100 kg m−3) and largest soil availability and leaf accumulation of N, P and K. The soil water distribution along the phenological stages was inconsistent and followed the trend according to the rainfall amounts; however, the contents increased with an increase in soil depth and irrigation regime. The predictive regressive models showed the linear relationships between the dry capsule yield and irrigation water and total water use by the plant.
Comparison of dissolved air flotation and sedimentation for the treatment of two waters with low turbidity in Colombia
Authors: González-Galvis Juan Pablo , Jaramillo Londoño Angela María , Sepúlveda Amaya Ruben Dario 
Published: June 2024

ABSTRACT

The main objective of this research was to conduct a comparative study between dissolved air flotation (DAF) and conventional sedimentation (SED) for the treatment of a reservoir water (REW) and small stream water (STW) with low turbidity and low alkalinity in Colombia at the bench-scale level. The experiments were conducted at the bench-scale using a jar test apparatus. Aluminum sulfate was used as the coagulant. The experimental results showed that with an optimum coagulant dose of 30 mg/L as alum to treat REW and 10 mg/L as alum to treat STW; the percentage turbidity removal by DAF and SED were 88–85% and 84–86%; apparent color removal were 65–62% and 87%; and UV-254 nm removal as a surrogate measurement for the concentration of NOM were 74–73% and 64–69%, respectively.
Efficient Synthesis of Mannopyranoside-based Fatty Acyl Esters: Effects of Acyl Groups on Antimicrobial Potential
Authors: Rahaman Md. Lutfor , Rahman Md. Atiqur , Hasnain Md. Mohin , Amran Mohammad , Bin Emran Talha , Khan Md Ashikur Rahaman , Patwary Md. Abdul Majed , Kazi Mohsin , Matin Mohammed Mahbubul 
Published: June 2024

Background:
The approval of Sucrose Fatty Acid Esters (SFAEs) as food additives/
preservatives with antimicrobial potential has triggered enormous interest in discovering new
biological applications. Accordingly, many researchers reported that SFAEs consist of various
sugar moieties, and hydrophobic side chains are highly active against certain fungal species.

Objective:
This study aimed to conduct aregioselective synthesis of SAFE and check the effect of
chain length and site of acylation (i.e., C-6 vs. C-2, C-3, C-4, and long-chain vs. short-chain) on
antimicrobial potency.

Methods:
A direct acylation method maintaining several conditions was used for esterification. In
vitro tests, molecular docking, and in silico studies were conducted using standard procedures.

Results:
In vitro tests revealed that the fatty acid chain length in mannopyranoside esters significantly
affects the antifungal activity, where C12 chains are more potent against Aspergillus species.
In terms of acylation site, mannopyranoside esters with a C8 chain substituted at the C-6 position
are more active in antifungal inhibition. Molecular docking also revealed that these mannopyranoside
esters had comparatively better stable binding energy and hence better inhibition, with the
fungal enzymes lanosterol 14-alpha-demethylase (3LD6), urate oxidase (1R51), and glucoamylase
(1KUL) than the standard antifungal drug fluconazole. Additionally, the thermodynamic, orbital,
drug-likeness, and safety profiles of these mannopyranoside esters were calculated and discussed,
along with the Structure-Activity Relationships (SAR).

Conclusion:
This study thus highlights the importance of the acylation site and lipid-like fatty acid
chain length that govern the antimicrobial activity of mannopyranoside-based SFAE.
Current Treatment Approaches for Alzheimer’s Disease and Possible Drug Targets
Authors: Ranjan Ashutosh , Shukla Shashikesh , Singh Shamsher 
Published: June 2024

Abstract:
Alzheimer's disease is a neurological condition that is becoming increasingly common and
is typified by dementia. Drug development for AD is a major issue with a startlingly high failure rate
despite a marked increase in the frequency of the disease linked to genetic factors. As AD is the most
common neurological illness and contributes to both the high patient burden and the cost of
healthcare, this issue must be addressed.
The current manuscript aims to focus on the current treatment approaches of newer drugs under clinical
trials of Alzheimer’s disease by targeting the various pathological pathways that are involved in
AD.
Data provided in this review are from literature surveys and ongoing clinical trials from reputed
search engines like PubMed, ResearchGate, Science Direct, and Google Scholar, as well as from
various respected authors and—registered websites such as memory.ucsf.edu/genetics/familial-Alzheimer’s-
disease and https://www.clinicaltrials.gov.
There are diverse forms of drugs and multiple pathways on which many advancements and clinical
trials have been conductedand are undergoing. Various investigations and studies are going on.
There are different pathogenesis of AD, such as Tau, vascular, Amyloid β, estrogen deficiency, and
the role of gut microbiota in AD. Donepezil, Rivastigmine, etc., are currently used for treatment, and
certain drugs are in different stages of clinical trials, such as ANI792, ACC-001, CAD106 &ABvac40,
and it is concluded that after successful trials of the new drugs, they can be used for the treatment
of AD with maximum benefits and less side effect.
A Comparative Review and Analysis of Computational Predictors for
Identification of Enhancer and their Strength
Authors: Gill Mehwish , Kabir Muhammad , Ahmed Saeed , Subhani Muhammad Asif , Hayat Maqsood 
Published: June 2024

Abstract:
Enhancers are the short functional regions (50–1500bp) in the genome, which play an
effective character in activating gene-transcription in the presence of transcription-factors (TFs).
Many human diseases, such as cancer and inflammatory bowel disease, are correlated with the enhancers’
genetic variations. The precise recognition of the enhancers provides useful insights for
understanding the pathogenesis of human diseases and their treatments. High-throughput experiments
are considered essential tools for characterizing enhancers; however, these methods are laborious,
costly and time-consuming. Computational methods are considered alternative solutions for
accurate and rapid identification of the enhancers. Over the past years, numerous computational
predictors have been devised for predicting enhancers and their strength. A comprehensive review
and thorough assessment are indispensable to systematically compare sequence-based enhancer’s
bioinformatics tools on their performance. Giving the increasing interest in this domain, we conducted
a large-scale analysis and assessment of the state-of-the-art enhancer predictors to evaluate
their scalability and generalization power. Additionally, we classified the existing approaches into
three main groups: conventional machine-learning, ensemble and deep learning-based approaches.
Furthermore, the study has focused on exploring the important factors that are crucial for developing
precise and reliable predictors such as designing trusted benchmark/independent datasets, feature
representation schemes, feature selection methods, classification strategies, evaluation metrics
and webservers. Finally, the insights from this review are expected to provide important guidelines
to the research community and pharmaceutical companies in general and high-throughput tools for
the detection and characterization of enhancers in particular.
Characteristics of Maxillofacial Trauma in Motorcycle Accidents at a Regional General Hospital in Indonesia: A Five-year Retrospective Study using the Facial Injury Severity Scale (FISS) and Maxillofacial Injury Severity Score (MFISS)
Authors: Ariawan Dwi , Dharmawan Dwi Kasta , Gondosudiro Retnowati , Julia Vera , Sulistyani Lilies Dwi , Ruslin Muhammad , Nakamura Norifumi 
Published: June 2024

Purpose
This study aimed to observe the correlations between factors that influence motorcycle accidents (such as accident time and helmet use) and the Facial Injury Severity Scale (FISS) and Maxillofacial Injury Severity Score (MFISS) scores in patients with maxillofacial trauma.

Methods
Data from maxillofacial trauma patients at the Tangerang Regency General Hospital in Banten, Indonesia, were retrospectively reviewed from June 2017 and May 2022 using the FISS and MFISS scores.

Results
A total of 257 patients were included in the study. Significant differences (p < 0.05) in FISS and MFISS based on accident time and helmet use were observed. Multivariate analysis revealed significant correlations (p < 0.05) between the factors and the maxillofacial trauma severity based on the FISS and MFISS.

Conclusion
The severity of maxillofacial trauma based on the MFISS was influenced by the accident time and helmet use. Similarly, the severity of maxillofacial trauma based on the FISS was directly related to the accident time; however, it was inversely related to the use of a helmet.
Characteristics of Dry Eye Syndrome in Patients with Mild Graves’ Ophthalmopathy
Authors: Bui Giang Thi Huong , Pham Dong Ngoc , Mai Tung Quoc , Pham Van Trong 
Published: June 2024

Introduction
This study aimed to assess dry eye in patients with mild Graves’ Ophthalmopathy (GO) at Vietnam National Eye Hospital.

Materials and Methods
This cross-sectional descriptive study evaluated dry eye syndrome in 40 eyes from 20 mild Graves’ ophthalmopathy patients from January 2021 to December 2021 at the Vietnam National Eye Hospital. As an age-matched control group, 44 eyes of 22 adults without thyroid disease were selected. The Ocular Surface Disease Index (OSDI), Tear Break-up Time (TBUT), Schirmer I tear test, and Corneal Fluorescein Staining (CFS) were assessed.

Results
The results showed that dry eye in patients with mild GO disease was significantly higher (65%), i.e., 3.98 times compared to the control group (65% and 30%, p<0.001, OR=3.98). The mean Schirmer I tear test score, TBUT score, CFS score, and OSDI score had a significant difference between GO and controls. Dry eye indices (TBUT, Schirmer I test, CFS) in mild GO patients were linearly correlated with proptosis, Margin-to-reflex Distance 1 (MRD1), and Clinical Activity Score (CAS). In the group of patients with active GO, the results of TBUT, Schirmer I test, CFS, and OSDI were statistically significantly higher than the inactive group (p < 0.05). Dry eye in the inflammatory group was 5.14 times higher than the non-inflammatory group (85.7% vs. 53.8%, p< 0.001, OR = 5.14).

Conclusion
Dry eye syndrome was frequently found in patients with mild GO, 3.98 times higher than the control group. Dry eye findings and the ocular surface damage in GO were severe in the group with active mild GO and 5.14 times higher than the inactive group.