bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charting the course: America's energy crossroads and the quest for a sustainable future
Authors: Oprea Simona‐Vasilica , Bâra Adela 
Published: May 2024

AbstractEnergy and environment views of over 10,000 American respondents are captured in a complex survey created by the Pew Research Center (PRC). This paper is based on data collected during a panel wave that took place in May 2022. The survey aims to capture the nuanced perspectives of a nationally representative group of U.S. adults, with particular attention to ensuring participation from traditionally underrepresented or hard‐to‐reach demographics. To analyze the responses, we cluster raw and encoded data and identify the main groups of respondents and their characteristics. Three main clusters are identified using K‐means (silhouette score of .78) with a larger cluster “Mainstream Respondents” that shows moderate views on energy and environmental issues. The second cluster “Outliers or Niche Group” is the smallest cluster representing respondents with unique or extreme views, high income or education levels or specific demographic attributes that set them apart from the majority. The third cluster “Specific Interest Group” has moderate size and characteristics that are distinct but not as extreme as the second cluster. On the other hand, two more balanced clusters (4265/6017) are obtained with K‐modes (Davies–Bouldin Index 2.61) using the unencoded data: “Traditional Energy Advocates” highlights the cluster's preference for traditional energy sources over alternative or renewable energy sources (RES), and “Sustainable Future Supporters” emphasizes the cluster's support for environmental sustainability and RES. These names aim to succinctly capture the essence of each cluster's predominant attitudes toward energy and environmental issues, reflecting their preferences and priorities. The results are significant for understanding trends within the U.S. population, informing policymakers and contributing to academic research.
Counsellors' verbal behaviours and skills that elicit participants' change or sustain talk in virtual motivational interviewing for physical activity among older adults
Authors: Akinrolie Olayinka , Strachan Shaelyn , Webber Sandra C. , Chan Hong , Messner Karla , Barclay Ruth 
Published: May 2024

AbstractExploring the influence of counsellors' verbal behaviours on participants' utterances in virtual motivational interviewing (MI) could broaden our understanding of how MI works. This study aims to determine counsellors' behaviours that are more or less likely than chance to elicit participants' change talk and sustain talk during a virtual MI intervention to promote physical activity among older adults. A sequential analysis was used to examine the transitional probability between the counsellors' and participants' behaviours. Thirty‐five MI sessions were analysed from the virtual motivational interviewing (VIMINT) trial. MI‐consistent behaviours (MICO) were significantly more likely than chance to be followed by change talk, sustain talk and follow/neutral talk. MI‐inconsistent behaviours (MIIN) were more likely than chance to be followed by change talk, and ‘other’ counsellors' behaviours were more likely than chance to be followed by change talk and follow/neutral talk. In conclusion, all three types of counsellors' behaviours elicited change talk. This study re‐emphasizes the link between MICO, change and sustain talk. The influence of MIIN and ‘other’ behaviours on change talk needs to be explored further. This study has implications for MI training and the need for counsellors to continuously develop skills or behaviours consistent with MI principles.
Targeted microwave ablation for prostate cancer (FOSTINE1b): a prospective ‘ablate‐and‐resect’ study
Authors: Peltier Alexandre , van Velthoven Roland , Baudewyns Arthur , Assenmacher Grégoire , Lemort Marc , Lefebvre Yolene , Sirtaine Nicolas , Diamand Romain 
Published: May 2024

ObjectiveTo assess histopathological outcomes, as well as feasibility and safety of targeted microwave ablation (TMA) via the Trinity® system (KOELIS, La Tronche, France).Patients and methodsProspective, single‐institution, interventional Phase IIa study with an ‘ablate‐and‐resect’ design. In all, 11 patients diagnosed with localised prostate cancer (PCa) underwent TMA via the Trinity system under conscious sedation in an outpatient setting using a single transrectal TATO® 18‐G antenna with different treatment regimens. Magnetic resonance imaging (MRI) and robot‐assisted radical prostatectomy (RARP) were conducted at 7 days and 1 month after TMA, respectively. Nine patients received RARP, and two patients chose to withdraw their consent following TMA. These men chose an active surveillance protocol upon confirmation of a low‐risk prostate cancer diagnosis. Functional outcomes and adverse events were evaluated at baseline and follow‐up visits using validated questionnaires. Prostate volumetry and confirmation of necrosis were carried out through MRI and whole‐mount histopathological examination.ResultsThe TMA was successfully executed, and all patients were discharged on the same day. No severe adverse events (Common Terminology Criteria for Adverse Events Grade ≥3) were reported at the 7‐day and 1‐month follow‐up visits. Additionally, no declines were observed in urinary, sexual and ejaculation functional outcomes. T1‐weighted MRI revealed clear and well‐defined ablation zones. The RARP was executed without difficulty, particularly during the dissection of the posterior plane. As a result, no intraoperative complications were encountered. Histopathological assessment on surgical specimens confirmed the absence of viable cells, indicating complete necrosis of the ablative zone if a power intensity >10 W was used during TMA. Ablation zone volumetry revealed no notable distinctions between the three‐dimensional segmentation of the virtual ablation zone at TMA (median volume: 2 mL) and MRI (median volume: 1.923 mL). Conversely, a significant reduction was noted in the surgical specimen (median volume: 0.221 mL).ConclusionsTargeted microwave ablation via the Trinity system for localised PCa treatment proves to be a secure and feasible procedure, with complete necrosis evidence within the ablation zone on surgical specimens.
Strike‐slip fault zone architecture and its effect on fluid migration in deep‐seated strata: Insights from the Central Tarim Basin
Authors: Liu Yin , Suppe John , Cao Yingchang , Wu Kongyou , Wang Jian , Du Yannan , Liu Yujie , Cao Zicheng 
Published: May 2024

AbstractThe internal fault architecture is crucial in assessing the significance of faults in fluid migration. The development of overlapping zones between segments and subsidiary structures is characteristic of a strike–slip faults. However, their internal architectures and roles in fluid migration are still poorly understood. The Tarim Basin's recently identified strike–slip faults imply that the petroleum resource is hosted in caves that were formed by subsequent dissolution after the formation of the fault zones in carbonate rocks, indicating that the internal fault architecture may be closely linked to the accumulation of petroleum. We investigated the architecture of the strike–slip fault zone using field, geochemical, seismic and well‐logging data. The results revealed that the strike–slip faults contain flower‐like structures in their vertical profiles and an en échelon and ‘X’ conjugate pattern in their horizontal slices. The fault core may become more complex because of the flower structure as fault breccia, slip surfaces, hydrothermal veins, dissolved pores and caves develop, and the damage zone contains multiple stages of fractures with high dip angles. Compared with ‘X’ pattern conjugate faults, NE‐trending strike–slip faults have a more developed and connected fault zone. The fault core acts as a fast conduit for fluid transport and experiences significant elemental losses, and the elemental variations in the damage zone may relate in long‐term and relatively lower‐level fluid–rock interactions. Three fault zone architecture models were created, namely, a releasing bend, a restraining bend and a single segment, and their controlling impacts on fluid migration were addressed accordingly. Our findings imply that fluid migration and accumulation are more favourable at the releasing bend than at the restraining bend and single segment.
Policy Interventions and Noncognitive Abilities of Children in Poor Areas: Effects and Mechanisms
Authors: Tian Yihao , Jin Mengyun , Shao Xuyang 
Published: May 2024

ABSTRACTNoncognitive abilities are the outcomes of long‐term investments in education and health. Changes in these abilities are critical to both the future development of individuals and the accumulation of national human capital. However, little attention has been paid to the noncognitive abilities of children in poor areas of China. Based on the China Family Panel Studies data and the differences‐in‐differences method, this study takes the Chinese government's implementation of the National Development Plan for Children in Poor Areas (2014–2020) as an entry point to examine the effects and mechanisms of policy interventions on children's noncognitive abilities in poor areas. We find that policy interventions significantly improve the noncognitive abilities of children in poor areas, with the main mechanisms of influence coming from two main pathways: the guarantee of children's education and the improvement of children's health. Specifically, rural girls, rural children from families in distress and those from families with less‐educated mothers were more sensitive to the policy and had more significant noncognitive improvement effects. After a series of robustness tests, these conclusions remain valid. This study enriches the corresponding research literature and provides useful policy insights on how to promote the holistic development of rural children in poor areas.
Human epididymis protein 4, a novel potential biomarker for diagnostic and prognosis monitoring of lung cancer
Authors: Zhang Tingting , Chu Lanhe , Tan Wenchong , Ye Cuiping , Dong Hangming 
Published: May 2024

AbstractObjectiveThis study aimed to explore the application value of human epididymis protein 4 (HE4) in diagnosing and monitoring the prognosis of lung cancer.MethodsFirst, TCGA (The Cancer Genome Atlas) databases were used to analyze whey‐acidic‐protein 4‐disulfide bond core domain 2 (WFDC2) gene expression levels in lung cancer tissues. Then, a total of 160 individuals were enrolled, categorized into three groups: the lung cancer group (n = 80), the benign lesions group (n = 40), and the healthy controls group (n = 40). Serum HE4 levels and other biomarkers were quantified using an electro‐chemiluminescent immunoassay. Additionally, the expression of HE4 in tissues was analyzed through immunohistochemistry (IHC). In vitro cultures of human airway epithelial (human bronchial epithelial [HBE]) cells and various lung cancer cell lines (SPC/PC9/A594/H520) were utilized to detect HE4 levels via western blot (WB).ResultsAnalysis of the TCGA and UALCAN (The University of Alabama at Birmingham Cancer Data Analysis Portal) databases showed that WFDC2 gene expression levels were upregulated in lung cancer tissues (p < 0.01). Compared with the control group and the benign group, HE4 was significantly higher in the serum of patients with lung cancer (p < 0.001). Receiver operating characteristic (ROC) analysis confirmed that HE4 had better diagnostic efficacy than classical markers in the differential diagnosis of lung cancer and benign lesions and had the highest diagnostic value in lung adenocarcinoma (area under the ROC curve [AUC] = 0.826). HE4 increased in early lung cancer and positively correlated with poor prognosis (p < 0.001). Moreover, the results of WB and IHC revealed that the expression of HE4 was increased in lung cancer cells (SPC/A549/H520) and lung cancer tissues but decreased in PC9 cells with a lack of exon EGFR19 (p < 0.05).ConclusionSerum HE4 emerges as a promising novel biomarker for the diagnosis and prognosis assessment of lung cancer.
Aortic, mitral and tricuspid valvular dysplasia in a 7‐month‐old colt
Authors: Bell Jillian , Shearer Patrick , Hale Josephine , Hughes Kristopher J. 
Published: May 2024

SummaryA 7‐month‐old Warmblood cross colt was presented for the assessment of a laceration of the right hind pastern of 4‐days duration. At presentation, the colt was in poor body condition and had a rough, dull coat. Cardiac auscultation revealed a grade 5/6 pansystolic murmur on the left side and grade 4/6 continuous murmur on the left and right sides and a regular cardiac rhythm. Electrocardiographic examination confirmed sinus tachycardia. Echocardiographic examination showed malformation of the aortic and mitral valves, with associated regurgitation and evidence of left atrial and ventricular volume overload. Dysplasia of the mitral, tricuspid and aortic valves was confirmed by post‐mortem examination. Valvular dysplasia is a rare cause of cardiac failure in horses.
Arachis pintoi Krapov. & W.C. Greg.–A multifunctional legume
Authors: de Sousa Isabela Brandão , de Oliveira Garcia Renata , Valls José Francisco Montenegro , Pacheco Georgia , Mansur Elisabeth 
Published: May 2024

AbstractArachis pintoi, commonly known as pinto or forage peanut, is used mainly in consortia with grass pastures and as cover plant. In addition to increasing the productivity of livestock and plantations, it contributes to the mitigation of environmental impacts (reduction of greenhouse gas emissions) and soil improvement (nitrogen fixation, reduction of fertilizers use), as well as to pests and disease management. Several cultivars that are tolerant to specific climates and soil conditions are suitable to be used as ground covers in agroforestry and silvopastoral systems, orchards, and plantations. Biotechnological and phytochemical investigations revealed the potential of pinto peanut as a sustainable source of resveratrol and other stilbenoids. Extracts from plants grown under natural conditions and from materials obtained in vitro displayed allelopathic, anthelmintic, or antioxidant activities. Other studies revealed the potential of pinto peanut for erosion control, phytoremediation, seed and essential oils production, materials for animal tissue engineering, synthesis of nanoparticles for drug delivery, and as green biorefineries to produce proteins, biochemicals, and biomaterials.
GLP‐1 agonists and hair loss: a call for further investigation
Authors: Desai Deesha D. , Sikora Michelle , Nohria Ambika , Bordone Lindsey , Caplan Avrom S. , Shapiro Jerry , Lo Sicco Kristen I. 
Published: May 2024

AbstractThe widespread adoption of glucagon‐like peptide‐1 (GLP‐1) agonists in treating type 2 diabetes mellitus (T2DM) and obesity has sparked investigations into their impact on hair health, an area characterized by diverse conjectures. Some propose potential risks such as disrupted hair growth cycles or premature androgenetic alopecia (AGA), while others suggest benefits linked to improved insulin sensitivity and enhanced scalp blood circulation. However, despite these theoretical underpinnings, clinical evidence linking GLP‐1 agonists to hair loss remains sparse. The necessity for vigilant patient monitoring and collaborative efforts cannot be overstressed in comprehensively addressing any potential consequences of GLP‐1 agonist therapy on hair health as their use continues to expand.
Robots et emploi: revue de la littérature
Authors: SHARFAEI Shahab 
Published: May 2024

RésuméLes progrès rapides de la robotique pourraient avoir des conséquences majeures sur l’économie mondiale et les sciences économiques. L'auteur passe en revue la littérature récente consacrée à ce sujet en se plaçant de deux points de vue. Premièrement, il analyse les travaux théoriques concernant les effets de la robotisation sur l'emploi et la capacité de différentes théories à décrire ces effets. Deuxièmement, il évalue les études empiriques relatives à l'impact de la robotisation sur l’économie, plus précisément sur l'emploi et la relocalisation de la production. Il met en lumière les limites de la littérature et des pistes pour de futurs travaux.
What is nursing in advanced nursing practice? Applying theories and models to advanced nursing practice—A discursive review
Authors: Zhang Yuhan 
Published: May 2024

AbstractAimThis article appraises models and theories related to advanced nursing practice. It argues that while the role of the advanced nurse practitioner builds on and extends beyond traditional nursing, it remains firmly grounded in ‘caring’.BackgroundThe stereotype that nurses ‘care’ and doctors ‘cure’ is fading. Increasingly, nurses have crossed boundaries and conducted independent assessment, diagnosis, prescribing and consultation, which used to be the doctor's role. Confusion and argument have arisen due to the higher‐level practice of the advanced nurse practitioner, as many questions where these ‘doctor nurses’ stand.DesignA literature review.Data SourcesDatabases, including CINAHL, Medline and Google Scholar, were searched.MethodDatabases were searched, and relevant studies and review articles from 1970 to 2023 were identified using the following keywords: ‘advanced nurse practitioner’, ‘nurse practitioner’, ‘advanced nursing’, ‘advance practice’, ‘nurse practitioner’, ‘nursing theory’ and ‘nursing model’.ResultsAlthough advanced nurse practitioners identify themselves as nurses, there is limited use of nursing theory to conceptualize this new level of practice and to define their contribution to the multi‐disciplinary team. It is noted that a holistic approach to personalized patient care, based on therapeutic relationships and effective communication, may help us identify the unique contribution of the advanced nurse practitioner.ConclusionsThe development of advanced nursing theory needs to capture this holistic approach and its caring element to recognize the value and strengthen the identity allegiance of this hybrid role.Implications for the Profession and/or Patient CareHolistic approach and patient‐centred care, effective communication and the therapeutic relationship are strong characteristics relating to ANP practice, the latter of which is yet to be clearly defined and captured in nursing theories. Conceptualizing ANP practice and capturing their valuable nursing care will enable better understanding and clarity for the role to realize its full potential.
Exploring the pharmacological mechanism of Glycyrrhiza uralensis against KOA through integrating network pharmacology and experimental assessment
Authors: Xu Jianbo , Sun Qi , Qiu Min , Wu Yungang , Cheng Liangyan , Jiang Nanwan , Zhang Ruogu , Chen Jiali , Yuan Wenhua , Jin Hongting , Wang Weidong , Cai Yunhuo , Zhang Chunchun , Wang Pinger 
Published: May 2024

AbstractKnee osteoarthritis (KOA), a major health and economic problem facing older adults worldwide, is a degenerative joint disease. Glycyrrhiza uralensis Fisch. (GC) plays an integral role in many classic Chinese medicine prescriptions for treating knee osteoarthritis. Still, the role of GC in treating KOA is unclear. To explore the pharmacological mechanism of GC against KOA, UPLC‐Q‐TOF/MS was conducted to detect the main compounds in GC. The therapeutic effect of GC on DMM‐induced osteoarthritic mice was assessed by histomorphology, μCT, behavioural tests, and immunohistochemical staining. Network pharmacology and molecular docking were used to predict the potential targets of GC against KOA. The predicted results were verified by immunohistochemical staining Animal experiments showed that GC had a protective effect on DMM‐induced KOA, mainly in the improvement of movement disorders, subchondral bone sclerosis and cartilage damage. A variety of flavonoids and triterpenoids were detected in GC via UPLC‐Q‐TOF/MS, such as Naringenin. Seven core targets (JUN, MAPK3, MAPK1, AKT1, TP53, RELA and STAT3) and three main pathways (IL‐17, NF‐κB and TNF signalling pathways) were discovered through network pharmacology analysis that closely related to inflammatory response. Interestingly, molecular docking results showed that the active ingredient Naringenin had a good binding effect on anti‐inflammatory‐related proteins. In the verification experiment, after the intervention of GC, the expression levels of pp65 and F4/80 inflammatory indicators in the knee joint of KOA model mice were significantly downregulated. GC could improve the inflammatory environment in DMM‐induced osteoarthritic mice thus alleviating the physiological structure and dysfunction of the knee joint. GC might play an important role in the treatment of knee osteoarthritis.
Infectious etiologies of persistent and chronic diarrhea in Asian developing countries: A systematic review and meta‐analysis
Authors: Koh Matthew Chung Yi , Tan Shi Ni , Ngiam Jinghao Nicholas , Tambyah Paul Anantharajah , Siah Kewin Tien Ho 
Published: May 2024

AbstractInfectious causes of diarrhea contribute significantly to morbidity in Asia. We conducted a systematic review and meta‐analysis of the prevalence of infectious etiologies of persistent and chronic diarrhea in Asian adults. Searches were performed on PubMed and Scopus for studies from January 1, 1970, to May 30, 2023. Sixteen studies were identified and included. The meta‐analysis was conducted with the random‐effects method, estimating the pooled prevalence of groups of infectious pathogens as causes of persistent and chronic diarrhea among Asian adults. The findings were highly heterogeneous and indicative of publication bias. The majority of studies were conducted on persons living with human immunodeficiency virus infection (PLHIV). The studies were predominantly from low‐income and middle‐income Asian countries. The most common cause was parasitic, with a pooled prevalence of 0.52 (95% confidence interval 0.28–0.65, I2 = 99%, Cochran's Q = 1027.44, P < 0.01), followed by bacterial, fungal, and viral causes, which were substantially rarer. Negative microbiological testing was also common, with a pooled prevalence for a negative test being 0.37 (95% confidence interval 0.17–0.52, I2 = 99%, Cochran's Q = 1027.44, P < 0.01). Subgroup analyses of studies conducted among PLHIV, from year 2000 and among those conducted in Southeast Asia showed a similar prevalence of parasitic causes of diarrhea. In conclusion, in Asian adults with persistent and chronic diarrhea, parasitic causes were most prevalent. However, the estimate of true prevalence is limited by significant heterogeneity among the available studies. More study in this field is required, especially examining PLHIV in the post‐antiretroviral therapy era and from high‐income countries.