bluuebunny/crossref_metadata_2025_split huggingface dataset:
A European Multicenter Randomized Double-blind Placebo-controlled Monotherapy Clinical Trial of Milnacipran in Treatment of Fibromyalgia
Authors: BRANCO JAIME C. , ZACHRISSON OLOF , PERROT SERGE , MAINGUY YVES 
Published: February 2010

Objective.This randomized, double-blind, placebo-controlled, multicenter study investigated the efficacy and safety of milnacipran in the treatment of fibromyalgia (FM) in a European population.Methods.Outpatients diagnosed with FM according to 1990 American College of Rheumatology criteria (N = 884) were randomized to placebo (n = 449) or milnacipran 200 mg/day (n = 435) for 17 weeks (4-week dose escalation, 12-week stable dose, 9-day down-titration), followed by a 2-week posttreatment period. The primary efficacy criterion was a 2-measure composite responder analysis requiring patients to achieve simultaneous improvements in pain (≥ 30% improvement from baseline in visual analog scale, 24-hour morning recall) and a rating of “very much” or “much” improved on the Patient Global Impression of Change scale. If responder analysis was positive, Fibromyalgia Impact Questionnaire (FIQ) was included as an additional key primary efficacy measure.Results.At the end of the stable dose period (Week 16), milnacipran 200 mg/day showed significant improvements from baseline relative to placebo in the 2-measure composite responder criteria (p = 0.0003) and FIQ total score (p = 0.015). Significant improvements were also observed in multiple secondary efficacy endpoints, including Short-Form 36 Health Survey (SF-36) Physical Component Summary (p = 0.025), SF-36 Mental Component Summary (p = 0.007), Multidimensional Fatigue Inventory (p = 0.006), and Multiple Ability Self-Report Questionnaire (p = 0.041). Milnacipran was safe and well tolerated; nausea, hyperhidrosis, and headache were the most common adverse events.Conclusion.Milnacipran is an effective and safe treatment for pain and other predominant symptoms of FM. Registered as trial no. NCT00436033.
MICRO-LEPIDOPTERA
Authors: Chambers V. T. 
Published: February 2010

C. uegerfasciella, ante p. 114, and C. minutisimella, ante p. 125.When the generic and specific characters of these insects were written –more than a year ago–I placed them, with much doubt, among the Micro-Lepidoptera. Sub equent examination has only served to increase those doubts, or rather, has convinced me that they are allied to the Hydroptilidoe, and are Trichopterous. if Hydroptila is Trichopterous. At the same time, it was partly because I was unable satisfacicrily to place them in Hydroptila, or any allied genus heretofore described, that I was induced to place them among Micro-Lepidoptera.
A GLIMPSE OF INSECT LIFE
Authors: BELL  
Published: February 2010

while looking over some o1d memoranda a few days ago, I found the following, ,which may Prove interesting to the readers of the Entomologist.In the summer of the year 1830, while residing in the northern part of the County of Northumberland, England, in the capacity of a farm student, I was requested to carry out a sentence of death upon a worthless cur, which had been condemned as an incorrigible cattle chaser.
MICRO-LEPIDOPTERA
Authors: Chambers V. T. 
Published: February 2010

Slate color, tinged with ochreous; apex of the abdomen yellowish ; two longitudinal dusky lines on top of the abdomen, which, however, are invisible in the dead specimen. Al. ex.,6/16 inch. Kentucky.The case is ochreous, slender, cylindrical, tapering a little to each end, and compressed or pinched at the posterior end, so as to divide it into three small ridges. It is about half an inch long, and was found adhering to the bark of sugar trees (Acer saccharinum.)
MICRO-LEPIDOPTERA
Authors: Chambers V. T. 
Published: February 2010

For the purpose of comparing it with the other species, I quote here Dr. Clemens' description of A. splendoriferella.“Head golden; antennæ fuscous, tinged with golden. Fore wings from the base to the middle leaden grey, with a splendant lustre, and from the middle to the tip golden, with a broad, nearly straight, metallic, silvery streak, extending from the costa, near the tip, to the middle of the wing, and dark margined on both sides.
THE LINNEAN SIGNIFICATION OF THE GENERIC TERM PAPILIO
Authors: Hagen H. 
Published: February 2010

In a recent issue of the Canadian Entomologist, No. viii, Vol. vi, there appears from the pen of Mr. Scudder a paper on “The Linnean Signification of the Generic Term Papilio,” containing some statements on which I propose to offer a few remarks.The data given by Scudder from Linné's works are-save some minor typographical errors-correct, excepting in two important points. On p. 144 he says “in the year 1846 the first edition of the Fauna Suecica was published, in which Linne for the first time treats of species, giving to them names in the language of the country,” (The italics are mine.)
STRAY NOTES ON CANADIAN DIPTERA
Authors: Morris Beverley R. 
Published: February 2010

The following fragmentary notes are submitted to the readers of the Canadian Entomologist in the hope that they may assist in even a small measure in determining the number of this order occurring in the Dominion.When in Canada I only incidentally captured Diptera, and the number I possess is very limited. I am indebted to F. Smith, Esq., of the British Museum, for the names of those given below.
THE LARVÆ OF DEPRESSARIA DUBITELLA AND GELECHIA RUBENSEELA
Authors: Murtfeldt Mary E. 
Published: February 2010

Being much interested in the Tineidæ, Mr. chambers' articles on this family of moths are the first to receive attention as the successive numbers of your magazine come to hand.I have had the satisfaction of rearing from their larvæ many of the winged gems described in your pages, among others the twospecies named above. Now, as Mr. C. seems to have been in some doubt as to his own determination of these specics, of which he has as yet-as he informs me seen only the imagines, it occurs to me that a description of their larval characteristics might affors some aid in deciding the doubtful points.
ON ENTOMOLOGICAL NOMENCLATURE
Authors: Leconte John L. 
Published: February 2010

“Ignorato genere proprio, nulla descriptio, quamvis accurate tradita certum demonstret; sed plerumque fa11at.”-Cæsalp. apud Linn., SystNat., xii, 1, 13.In the first part of this essay I endeavored to show the confusion which resulted from the application of the law of priority to the names employed in the early development of our science by persons who had no idea corresponding to the law which has since been formulated. We will now attempt to discuss the second great fallacy in the exegesis of the writings of the founders of the science ; the selection on principles, more or less arbitrary, but always opinionative, of generic types, when these have not been explicitly mentioned by the author.
TINEINA FROM TEXAS
Authors: Chambers V. T. 
Published: February 2010

A collection of Tineina received from Mr. Belfrage, of Waco, Texas, presents some points worthy of mention apart from the descriptions of the new species.The collection consists of about two hundred and fifty specimens in tolerably good condition, referable to seventy-six species and twenty-seven genera. Such a number of genera and species is evidently typical of the Tineina of thelocality where they were collected.
ON ANISOPTERYX VERNATA AND POMETARIA
Authors: Morrison H. K. 
Published: February 2010

There has been some coufusion lately in regard to the limits and synonymy of these two common species, partially due to Dr. Harris' unsatisfactory reference to them in his “Report on the Insects of Massachusetts.” 1841. and to the inaccessibility of Prof. Peck's original descripticn of A. vernata.In the numerous notes on these species and references to them in recent publications, they are in nearly allcases confounded together or wrongly determined; and I have not found them correctly named in a single collection which I have examined.
MICRO-LEPIDOPTERA
Authors: Chambers V. T. 
Published: February 2010

The little insect which I have made the type of this new genus, unites in itself the characters of several genera.Tongue naked, about as long as the maxillary palpi, which nearly conceal it. The maxillary palpi are about as long as the labial palpi and in the dead insect are laid upon the coxae ; they are rather densely scaled, the scales being somewhat roughened.
DESCRIPTION OF PACHNOBIA ORILLIANA
Authors: Grote Aug. R. 
Published: February 2010

Both sexes of a species of Pachnobia have been collected by Mr. Geo Norman, at Orilla, which I propose to call by the name of orilliana. It is evidently allied to Agrotis hyperborea, which I know only from Milliére's and Herrich-Schaeffer's illustrations. It looks at first sight like a species of Graphiphora (Taeniocampa).All the tibiae are spinose. The head is sunken, eyes naked, abdomen short. The wings are wide, the male antennae shortly pectinate, serose. The color is not unlike that of Graph. incerta, but more olivaceous.
CAPTURES OF NOCTUIDÆ AT ST. CATHARINES, ONT
Authors: Norman Geo. 
Published: February 2010

In the spring of this year I commenced collecting the Nectuæof this part of Canada, and in the hope that a list of my captures, with the dates of appearance, may be of interest, I venture to send the same for publication.Being a stranger to the insect fauna of N. America, and in the absence of anything like a manual of the Heterocera, I shouls, even with the assistance of the Brit. Mus. Catalogues and Gueneæ's work, have had great difficulty in identifying my specimens.
LARVA OF ANAPHORA AGROTIPENNELLA
Authors: Murtfeldt Mary E. 
Published: February 2010

In Vol. 4, p. 137, of the Canadian Entomologist, Mr. Grote first published a description of the large and characteristic Tineid above named. The imago has been very common with us for several years, but until the present season its larval history had eluded my investigation.Early in April I found among the roots of a bit of white clover sod a very active and singular larva, whose long and rather sprangling thoracic legs gave it, at first glance, the appearance of a Coleopterous larva. A second look, however, discovered the characteristics of a Lepidopteron of which the following description was taken:Length, 0.75 inch.; diameter greatest at head and 1st joint, slightly tapering thence posteriorly.
ON PLATYSAMIA COLUMBIA Smith
Authors: Caulfield F. B. 
Published: February 2010

In No. 4, Vol. ii, of the “Bulletin of the Buffalo Society of Natural Sciences,” Dr. H. A. Hagen gives an interesting paper on this moth and its parasites.After a brief review of the previous literature of the species, Dr. Hagen says : “If columbia should happen not to be a distinct species, it must be either a variety of some other species or a hybrid of two species.”
Microglia and macrophages in glioblastoma: landscapes and treatment directions
Authors: Solomou Georgios , Young Adam M. H. , Bulstrode Harry J. C. J. 
Published: May 2024

Glioblastoma is the most common primary malignant tumour of the central nervous system and remains uniformly and rapidly fatal. The tumour‐associated macrophage (TAM) compartment comprises brain‐resident microglia and bone marrow‐derived macrophages (BMDMs) recruited from the periphery. Immune‐suppressive and tumour‐supportive TAM cell states predominate in glioblastoma, and immunotherapies, which have achieved striking success in other solid tumours have consistently failed to improve survival in this ‘immune‐cold’ niche context. Hypoxic and necrotic regions in the tumour core are found to enrich, especially in anti‐inflammatory and immune‐suppressive TAM cell states. Microglia predominate at the invasive tumour margin and express pro‐inflammatory and interferon TAM cell signatures. Depletion of TAMs, or repolarisation towards a pro‐inflammatory state, are appealing therapeutic strategies and will depend on effective understanding and classification of TAM cell ontogeny and state based on new single‐cell and spatial multi‐omic in situ profiling. Here, we explore the application of these datasets to expand and refine TAM characterisation, to inform improved modelling approaches, and ultimately underpin the effective manipulation of function.
Coupling of Infrared Active Colloidal Quantum Dots and Amorphous Selenium for Fast and Sensitive Photodetection
Authors: Mølnås Håvard , Mukherjee Atreyo , Kannan Haripriya , Han Zhihang , Ravi Vikash K. , Paul Shlok J. , Rumaiz Abdul K. , Zhao Wei , Goldan Amir H. , Sahu Ayaskanta 
Published: May 2024

AbstractColloidal quantum dot (CQD) based infrared (IR) photodetectors offer facile wavelength tunability in the IR and low‐cost fabrication. However, owing to their large surface areas, CQDs intrinsically have significant surface traps critically affecting the speed of CQD photodetectors, typically mediated through tedious surface passivation efforts. In this report, an alternative strategy involving coupling of near‐IR photoactive lead sulfide CQDs with a thermally evaporated amorphous selenium (a‐Se) hole transport layer is proposed. By separating the detector into a photon absorbing CQD region and a charge transport a‐Se region, the study takes advantage of the extremely low noise, predominantly hole‐only transport process in a‐Se. A high 3 dB bandwidth of 2.5 MHz and a competitive specific detectivity of 2.5 × 1011 Jones at room temperature are demonstrated at 980 nm. This report serves as a first demonstration of strong coupling between an IR active CQD absorber and a‐Se, which paves the path to obtain fast and highly photoresponsive IR photodetection in the future.
Unraveling the Reasons Behind SnO2/Perovskite Defects and Their Cure Through Multifunctional Ti3C2TX
Authors: Khan Danish , Muhammad Imran , Qu Geping , Gao Changqin , Xu Jiamin , Tang Zeguo , Wang Yang‐Gang , Xu Zong‐Xiang 
Published: May 2024

AbstractThe rationale for low performances in perovskite solar cells with buried interface still needs to be clarified, owing to the complicated physiochemistry of metal oxides/perovskite interface, and literature offers a meager knowledge about the reactions at this interface. While exploring the SnO2/perovskite interfacial interactions, the reasons behind deteriorating perovskite at the interface are comprehensively investigated, and it is revealed that the PbI2 residue and metallic Pb0 are the byproducts of this decomposed perovskite. Introducing an optimized amount of Ti3C2TX at the SnO2/perovskite interface detaches the SnO2 hydroxyls, which are found to be responsible for interfacial ion migrations. In addition, Ti3C2TX passivates the interface defects via its functional groups and establishes ballistic pathways for electrons with high chances of non‐radiative recombination. Thus, 25.19% (certified as 24.41%) of efficiency with superior long‐term operational stability is achieved.
Radioiodine‐Mediated Transition Metal Valence Conversion for Enhanced Chemodynamic Therapy
Authors: Wang Tao , Wang Chaochao , Wang Ya , Zhang Xuelian , Cai Xuechao , Guo Zhongqiu , Meng Xianfu , Jiang Xingwu , Wu Yelin , Cao Yi , Zuo Changjing , Bu Wenbo 
Published: May 2024

AbstractChemodynamic therapy (CDT) presents promise as a cancer treatment method, but its efficacy faces challenges due to the inefficient Fenton catalytic reaction, where the transition metals' conversion from high to low valence states acts as the rate‐limiting step. Here, a strategy employing radioiodine is introduced to facilitate the valence conversion of transition metals for CDT enhancement. Iron‐based metal‐organic framework (MOF) nanoparticles (NPs) are synthesized labeled with radioiodine‐125 (125I), referred to as 125I‐MIL‐88B(Fe) NPs. These NPs possess a porous structure capable of concentrating and catalyzing H2O2 to generate highly toxic hydroxyl radicals (·OH). Furthermore, 125I can continuously produce hydrated electrons (eaq−) in aqueous environments, promoting the conversion of Fe3+/Fe2+ to boost ·OH production. In vitro and in vivo experiments validate the enhanced CDT effect on pancreatic cancer, driven by the reactive oxygen species (ROS)/mitogen‐activated protein kinase (MAPK)/p53 pathway‐mediated cell apoptosis. The radioiodine‐mediated electron‐supplying strategy not only amplifies the effectiveness of CDT but also unlocks new potential applications for radionuclides.
Small‐Bandgap Transducers Induced Carrier Separation for In Situ Dual‐Amplified Tumor Oxidative Stress
Authors: Hu Guangyao , Wang Jiarui , Chen Lulu , Zheng Haoqin , Lan Yuanpei , Wang Kaiyang , Liu Xijian , You Hongpeng , Luo Yu , Dong Lile 
Published: May 2024

AbstractThe inherent and unique charge‐carrier release characteristics of piezoelectric sonosensitizers with desired bandgap can be leveraged to initiate reactive oxygen species (ROS) reactions that have considerable potential for sonodynamic therapy (SDT). In this study, a bimetallic Bi4NbO8Br‐polyvinylpyrrolidone (BNOBP) with a small bandgap (2.45 eV) is synthesized as a potential piezoelectric sonosensitizer. The robust interactions within and between the Bi─O and Nb─O layers narrow the bandgap, facilitating carrier transfer. Concurrently, compared with that of TiO2 and BiOBr, BNOBP exhibits a rapid acoustoelectric response and desirable electron–hole separation efficiency, enabling the generation of ·O2− under ultrasound (US) irradiation. Notably, BNOBP alleviates the overexpression of glutathione (GSH) in tumors and prevents the consumption of the generated ROS by GSH. Combining the previous small bandgap endow the high ROS generation efficiency, this study provides a paradigm for in situ regulation of oxidative stress levels in tumor tissue microenvironment based on bimetallic piezoelectric sonosensitizers.
Applications of Biodegradable Polymers in the Encapsulation of Anticancer Metal Complexes
Authors: Redrado Marta , Xiao Zhimei , Upitak Kanokon , Doan Bich‐Thuy , Thomas Christophe M. , Gasser Gilles 
Published: May 2024

AbstractMetal complexes have recently attracted a lot of attention, particularly as anticancer and antibacterial agents, owing to their versatile mechanisms and easily tunable characteristics. However, the application of such compounds in a medical context, especially in cancer treatment, has been hampered due to their limited solubility and stability in water and aqueous solutions, as well as a lack of selectivity. To address these limitations, several approaches have been developed to improve the targeted delivery of these compounds and their solubility. The first strategy involves the physical encapsulation of these metal complexes within carriers to facilitate controlled drug release. The second strategy involves covalently linking metal complexes to polymers, creating prodrugs that can be converted to active drugs at a more controllable rate. Despite the increasing variety of polymers available, the need to develop those able to be metabolized by the body, producing non‐toxic residues, remains crucial for effective treatment, particularly in the area of diseases such as cancer. In this perspective article, an overview of recent developments in the encapsulation of metal complexes using biodegradable polymers for cancer therapy is provided. It is specifically highlighting how the formed nanoparticles (NPs) enhance the selectivity and toxicity toward cancer cells compared to the parent metal complex, while simultaneously reducing the harmful side effects of traditional chemotherapies, opening the door for using them in combination therapies (PDT, PTT).
Construction of an Internal Charge Field: CoS1.097/Ni3S2 Heterojunction Promotes Efficient Urea Oxidation Reaction
Authors: Du Mingxuan , Ji Yujin , Li Youyong , (Frank) Liu Shengzhong , Yan Junqing 
Published: May 2024

AbstractUrea oxidation reaction (UOR) features a lower overpotential compared to the oxygen evolution reaction (OER) during electrolysis, facilitating the hydrogen evolution reaction (HER) at the cathode. The distribution of charge plays a pivotal role in promoting the adsorption and cleavage of chemical groups in urea molecules, which can be modulated by introducing a heterostructure. Herein, a CoS1.097/Ni3S2 heterojunction grown on nickel foam is designed, serving simultaneously for UOR and HER. Based on density functional theory (DFT) calculations, the spontaneous charge transfer at the CoS1.097/Ni3S2 heterointerface induces the formation of localized electrophilic/nucleophilic regions, intelligently adsorbing electron‐donating/electron‐withdrawing groups in urea molecules, activating chemical bonds, thereby triggering urea decomposition. CoS1.097/Ni3S2 exhibits excellent catalytic activity for urea, requiring only a potential of 1.22 V (with an overpotential of 0.85 V) to achieve a current density of 100 mA cm−2 in UOR, and potentials of 1.27 and 1.57 V to reach current densities of 10 and 100 mA cm−2, respectively, in a UOR//HER electrolysis cell, maintaining good stability at high current density for 60 h. Tests in real urine have demonstrated performance similar to that in urea electrolyte. This work represents nearly the best catalytic performance of transition metal‐based materials in UOR applications, promising for both efficient hydrogen production and urea decomposition.
Formation of N‐Doped Carbon Nanofibers Decorated with MoP Nanoflakes for Dendrite‐Free Lithium Metal Anode
Authors: Chen Duhong , Chen Chen , Yu Huan , Zheng Saiyan , Jin Tong , Li Nian Wu , Yu Le 
Published: May 2024

AbstractMetallic lithium (Li) is recognized as a promising candidate for anode material of Li‐ion batteries owing to high theoretical specific capacity and low redox potential. However, uncontrollable dendrite growth and huge volume expansion during Li plating/stripping processes hinder its practical application. Herein, N‐doped carbon nanofibers@MoP nanoflakes (NCNF@MoP) is developed as a potential host to address the above challenges. During the formation of solid electrolyte interphase, MoP nanoflakes can be changed into metallic Mo with high lithiophilicity and Li3P with high ionic conductivity. The whole composite host is transformed into a mixed ion/electron conducting network to reduce nucleation overpotential and accelerate diffusion kinetics at the electrode/electrolyte interface. As a proof of concept, the symmetric cell using NCNF@MoP host presents a long‐term cycling up to 2500 h with a low nucleation overpotential of 10 mV at 1 mA cm−2. Additionally, the Li‐NCNF@MoP||LiFePO4 full cell demonstrates a good capacity retention of 92.6% over 2200 cycles at a high current density of 5C (1 C = 169 mA g−1).
Curcuma Longa: Nutraceutical Use and Association With Nanotechnology
Authors: Corrêa Carvalho Gabriela , Marena Gabriel Davi , Gaspar Gonçalves Fernandes Micaela , Ricci Leonardi Gabriela , Santos Hélder A. , Chorilli Marlus 
Published: May 2024

AbstractCurcumin is a natural product found in the rhizome of Curcuma longa (L.) and other Curcuma spp. As a lipophilic molecule, it has greater affinity for polar, non‐polar, alkaline, or extremely acidic organic solvents. Several studies indicate that curcumin has several benefits for human health, for example, against degenerative diseases, cancer, and infectious diseases. To obtain a quality product with nutraceutical properties, it is necessary to know its physicochemical characteristics and preserve it from cultivation until ingestion by the human. However, its low solubility leads to low absorption; in this context, nanotechnological systems can contribute to increase curcumin bioavailability. This review aims to highlight important issues in all stages that curcumin goes through: from aspects related to its extraction to its association with nanotechnology. Although curcumin extraction process is already well established, it is possible to observe more and more research focused on increasing yield and being more environmentally friendly. Further, curcumin's low absorption is notable due to its physicochemical characteristics, mainly due to its low aqueous solubility. However, its association with nanotechnology shows to be promising and an increasingly growing trend because the use of this “Indian solid gold” is the hope of many patients.