bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estrogen receptor‐β gene polymorphism and colorectal cancer risk: Effect modified by body mass index and isoflavone intake
Authors: Honma Naoko , Yamamoto Ken , Ohnaka Keizo , Morita Makiko , Toyomura Kengo , Kono Suminori , Muramatsu Masaaki , Arai Tomio , Ueki Takashi , Tanaka Masao , Kakeji Yoshihiro , Maehara Yoshihiko , Okamura Takeshi , Ikejiri Koji , Futami Kitaroh , Maekawa Takafumi , Yasunami Yohichi , Takenaka Kenji , Ichimiya Hitoshi , Terasaka Reiji 
Published: June 2012

AbstractEstrogen receptor (ER)‐β signaling has generally been implicated in protection against colorectal cancer. The ER‐β gene cytosine‐adenine (ESR2 CA) repeat polymorphism was reported to be associated with colorectal cancer, although showing contradicting results probably caused by ethnicity or age distribution of the subjects. We investigated the association between this polymorphism and the colorectal cancer risk in a community‐based case‐control study in Japan (685 cases/778 controls), including only subjects younger than 75. The effect modifications of the body mass index (BMI) and isoflavone intake were also examined. ESR2 CA repeat polymorphism was determined by polymerase chain reaction using fluorescein‐labeled primers. CA repeat alleles were classified into short (S) allele (<22 repeats) and long (L) allele (≥22 repeats). Subjects were divided into three genotype groups (SS/SL/LL). The risk of colon cancer, but not of rectal cancer, was increased with an increasing number of L alleles among postmenopausal women; age‐adjusted odds ratio (OR) for SL and LL genotypes compared with the SS genotype were 1.78 and 2.91, respectively (trend p = 0.002). Increased risks of colon cancer associated with the L allele were more evident among postmenopausal women with low BMI (<25 kg m−2) or with high isoflavone intake. Such associations were not observed among men or premenopausal women. Having longer ESR2 CA repeat increases colon cancer risk among postmenopausal women younger than 75, possibly with modification of BMI and isoflavone intake. Aging and estrogenic condition may be important in the colon cancer pathogenesis associated with ESR2 CA repeat polymorphism.
Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer
Authors: Recio‐Vega Rogelio , Mendez‐Henandez Alejandra , Gabriel Antonio Padua y , Jacobo‐Avila Antonio , Portales‐Castanedo Arnulfo , Hernandez‐Gonzalez Sandra , Gallegos‐Arreola Martha Patricia , Ocampo‐Gomez Guadalupe 
Published: June 2012

ABSTRACTLung cancer is the most common cancer in the world. The main cause of lung cancer is cigarette smoke; however, other important genetic and environmental risk factors play a significant role in the development of lung cancer. Among these factors, occupational and accidental exposure to polychlorinated biphenyls (PCBs) has been associated with an increased risk in lung cancer, suggesting that PCBs could be potent carcinogens. The aim of the present study was to investigate the association between PCB exposure levels, CYP1A1 polymorphisms and the risk of lung cancer. This study enrolled newly diagnosed lung cancer patients. Environmental and occupational information related to the patients studied was collected. Blood samples were taken for the measurement of serum levels of 20 PCB congeners and for CYP1A1 polymorphism analysis. The serum levels of two PCB congeners with potential estrogenic activity were higher in lung cancer patients. The risk of lung cancer was found to correlate with age, gender, smoking history and with agricultural workers, as well as with congener 18. No differences were found in the frequency of CYP1A1 polymorphisms. Furthermore, we did not find a correlation between CYP1A1 polymorphisms and PCB serum levels. The high levels of PCB with estrogenic activity found in our cases, could promote lung cancer inducing cell proliferation in non‐neoplastic and neoplastic lung cells via ERβ; inducing the formation of DNA adducts, producing oxidative stress with the subsequent DNA damage and increasing the endogenous catechol levels by catechol‐O‐methyl transferase (COMT) inhibition. Copyright © 2012 John Wiley & Sons, Ltd.
Distribution of bone density in the proximal femur and its association with hip fracture risk in older men: The osteoporotic fractures in men (MrOS) study
Authors: Yang Lang , Burton Annabel C , Bradburn Mike , Nielson Carrie M , Orwoll Eric S , Eastell Richard ,   for the Osteoporotic Fractures in Men (MrOS) Study Group
Published: June 2012

Abstract
This prospective case-cohort study aimed to map the distribution of bone density in the proximal femur and examine its association with hip fracture. We analyzed baseline quantitative computed tomography (QCT) scans in 250 men aged 65 years or older, which comprised a randomly-selected subcohort of 210 men and 40 cases of first hip fracture during a mean follow-up period of 5.5 years. We quantified cortical, trabecular, and integral volumetric bone mineral density (vBMD), and cortical thickness (CtTh) in four quadrants of cross-sections along the length of the femoral neck (FN), intertrochanter (IT), and trochanter (TR). In most quadrants, vBMDs and CtTh were significantly (p &lt; 0.05) lower in cases compared to the subcohort and these deficits were present across the entire proximal femur. To examine the association of QCT measurements with hip fracture, we merged the two quadrants in the medial and lateral aspects of the FN, IT, and TR. At most sites, QCT measurements were associated significantly (p &lt; 0.001) with hip fracture, the hazard ratio (HR) adjusted for age, body mass index (BMI), and clinical site for a 1-SD decrease ranged between 2.28 (95% confidence interval [CI], 1.44–3.63) to 6.91 (95% CI, 3.11–15.53). After additional adjustment for total hip (TH) areal BMD (aBMD), trabecular vBMDs at the FN, TR, and TH were still associated with hip fracture significantly (p &lt; 0.001), the HRs ranged from 3.21 (95% CI, 1.65–6.24) for the superolateral FN to 6.20 (95% CI, 2.71–14.18) for medial TR. QCT measurements alone or in combination did not predict fracture significantly (p &gt; 0.05) better than TH aBMD. With an area under the receiver operating characteristic curve (AUC) of 0.901 (95% CI, 0.852–0.950), the regression model combining TH aBMD, age, and trabecular vBMD predicted hip fracture significantly (p &lt; 0.05) better than TH aBMD alone or TH aBMD plus age. These findings confirm that both cortical and trabecular bone contribute to hip fracture risk and highlight trabecular vBMD at the FN and TR as an independent risk factor. © 2012 American Society for Bone and Mineral Research.
Protective efficacy of ellagic acid on glycoproteins, hematological parameters, biochemical changes, and electrolytes in myocardial infarcted rats
Authors: Kannan M. Mari , Quine S. Darlin , Sangeetha T. 
Published: June 2012

AbstractThe cardioprotective property of ellagic acid in rats has been reported previously. The present study reveals the protective role of ellagic acid in biochemical parameters including serum iron, plasma iron binding capacity, uric acid, glycoprotein, and electrolytes along with hematological parameters. Rats were subcutaneously injected with isoproterenol (ISO) (100 mg/kg) for 2 days to induce myocardial infarction. ISO‐induced rats showed a significant increase in their levels of serum iron, serum uric acid, and blood glucose, and a significant decrease in their levels of plasma iron binding capacity, serum total protein, albumin/globulin ratio, and heart glycogen, when compared with normal control rats. The altered hematological parameters were also observed in ISO‐induced rats when compared with normal control rats. Pretreatment with ellagic acid at doses of 7.5 and 15 mg/kg produced significant beneficial effect by returning all the above‐mentioned biochemical and hematological parameters to near normal levels. © 2012 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:270–275, 2012; View this article online at wileyonlinelibrary.com. DOI 10:1002/jbt.21418
Demographic, laboratory, and operational variables that influence short‐ and long‐term plateletpheresis yields
Authors: Badami K. G. , Sesun M. , Basu A. , Absalom N. 
Published: June 2012

AbstractWe studied the demographic, laboratory, and operational parameters that might influence individual, as well as average, plateletpheresis yields. Multivariate linear regression analyses showed that 25.4% and 11.6% of variability, among males and females, respectively, in individual yields was explained by the platelet count prior to that donation and 55% of the variation in mean platelet yields (PYs) was explained by the pre‐first donation platelet count, the first donation PY and the body mass index (BMI). Logistic regression analysis showed that donors with first donation PYs higher, compared to those with lower yields, than the median of all mean PYs were more likely to be relatively high platelet yielders over the long term. A statistically significant, although clinically insignificant, decline in predonation platelet counts is seen in all donors regardless of the total number of donations or interdonation interval. Donors with high pre‐first donation platelet counts, first donation yields, and BMI are likely to be consistent good platelet yielders. J. Clin. Apheresis 27:247–254, 2012. © 2012 Wiley Periodicals, Inc.
Unusual motion detected on real‐time sonography inside a glomus tumor in the thigh
Authors: Werner Jeff D. , Wright Chadwick L. , Iwenofu O. Hans , Patil Sumukh B. , Yuh William T.C. 
Published: June 2012

AbstractGlomus tumors are rare and many have been reported to have a hypervascular appearance on color or power Doppler sonography. We report a pathologically proven case of superficial glomus tumor within the thigh with no detectable color flow signals on color or power Doppler sonography. In addition, real‐time sonography showed spontaneous motions within the tumor, which were not synchronized with vascular or respiratory motions, and misled the presurgical diagnosis of a suspected parasite in a patient who had direct contact with multiple animal species. The etiology of this internal motion remains hypothetical but, if reconfirmed, this finding may be a useful adjunctive sign for the diagnosis of glomus tumors. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2013
Granular cell tumor in a male breast: Mammographic, sonographic, and pathologic features
Authors: Patel Hiten B. , Leibman A. Jill 
Published: June 2012

AbstractGranular cell tumor (myoblastoma) is a rare soft tissue tumor that can present in the breast, producing mammographic and physical exam findings that may be indistinguishable from breast carcinoma. Multifocal lesions in male patients are very unusual. We present a case of a male patient with a granular cell tumor of the breast that was imaged on mammography and sonography. Definitive diagnosis was made with ultrasound‐guided core biopsy followed by surgical excision. On clinical examination, the patient demonstrated multiple subcutaneous lesions that were also found to represent granular cell tumor. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound, 2013
Development of yolk sac and chorioallantoic membranes in the Lord Howe Island skink, Oligosoma lichenigerum
Authors: Stewart James R. , Russell Kylie J. , Thompson Michael B. 
Published: June 2012

AbstractDevelopment of the yolk sac of squamate reptiles (lizards and snakes) differs from other amniote lineages in the pattern of growth of extraembryonic mesoderm, which produces a cavity, the yolk cleft, within the yolk. The structure of the yolk cleft and the accompanying isolated yolk mass influence development of the allantois and chorioallantoic membrane. The yolk cleft of viviparous species of the Eugongylus group of scincid lizards is the foundation for an elaborate yolk sac placenta; development of the yolk cleft of oviparous species has not been studied. We used light microscopy to describe the yolk sac and chorioallantoic membrane in a developmental series of an oviparous member of this species group, Oligosoma lichenigerum. Topology of the extraembryonic membranes of late stage embryos differs from viviparous species as a result of differences in development of the yolk sac. The chorioallantoic membrane encircles the egg of O. lichenigerum but is confined to the embryonic hemisphere of the egg in viviparous species. Early development of the yolk cleft is similar for both modes of parity, but in contrast to viviparous species, the yolk cleft of O. lichenigerum is transformed into a tube‐like structure, which fills with cells. The yolk cleft originates as extraembryonic mesoderm is diverted from the periphery of the egg into the yolk sac cavity. As a result, a bilaminar omphalopleure persists over the abembryonic surface of the yolk. The bilaminar omphalopleure is ultimately displaced by intrusion of allantoic mesoderm between ectodermal and endodermal layers. The resulting chorioallantoic membrane has a similar structure but different developmental history to the chorioallantoic membrane of the embryonic hemisphere of the egg. J. Morphol. 2012. © 2012 Wiley Periodicals, Inc.
Influence of different cultivation methods on carbohydrate and lipid compositions and digestibility of energy of fruits and vegetables
Authors: Jørgensen Henry , Bach Knudsen Knud Erik , Lauridsen Charlotte 
Published: June 2012

AbstractBACKGROUND: Environmental as well as cultivation factors may greatly influence the chemical composition of plants. The main factors affecting the chemical composition of foodstuff are level and type of fertilizer (conventional and organic cultivation systems), location or soil type, and year of harvest. Organic foods are defined as products that are produced under controlled cultivation conditions characterized by the absence of synthetic fertilisers and very restricted use of pesticides. Very limited information is available regarding the impact of organic cultivation systems on the composition of carbohydrates and fatty acids of fruits and vegetables. The objective was to investigate the influence of organic and conventional cultivation systems on the carbohydrate and fatty acid composition and digestibility of the energy of apple, carrot, kale, pea, potato, and rape seed oil.RESULTS: Carbohydrate and lignin values ranged from 584 g kg−1 dry matter in kale to 910 g kg−1 DM in potato, but with significant differences in the proportion of sugars, starch, non‐starch polysaccharides, and lignin between the foodstuffs. Triacylglycerol was the major lipid class in pea, with 82% of total fatty acids, as opposed to apple, with only 35% of fatty acids of the ether extract. The most important factor influencing the digestibility of energy, and consequently faecal bulking, was the content of dietary fibre.CONCLUSION: The cultivation system had minor impact on the carbohydrate and lipid composition in the investigated foodstuffs or on the digestibility of energy when assessed in the rat model. Faecal bulking was related to dietary fibre in a linear fashion. Copyright © 2012 Society of Chemical Industry
Simplifying complex PTSD: Comment on Resick et al. (2012)
Authors: Bryant Richard A. 
Published: June 2012

AbstractAlthough constructs related to complex posttraumatic stress disorder (CPTSD) have been discussed for many years, the field still lacks reliable and standardized definitions to guide research in this field. This comment responds to the article by Resick et al. (2012), who conclude that CPTSD lacks sufficient support to be recognized as a diagnosis. Even though there is no doubt that research is lacking, this comment argues that the key to progressing the field is introducing a standardized definition that will allow researchers to understand CPTSD in relation to other trauma‐related disorders, identify key mechanisms driving the condition, and further treatment programs specifically for patients with CPTSD.
Passion and purpose: Leading from the inside out
Authors: Love Alaina 
Published: June 2012

AbstractLove believes that leadership requires self‐discovery. “Deep awareness of the skills, talents, and knowledge that shape you is important,” she writes, “but you must also know the inner purpose and passions that drive you so that you're able to inspire the people you lead.” Three factors are described that help leaders to leave a lasting legacy, while unleashing energy: personal fulfillment is directly connected to motivation at work; fulfillment escalates if there is an opportunity to translate purpose in life to work contributions; and the attainment of purpose/passion should be part of an organization's dialogue.
Consumers’ Views of Feng Shui: Antecedents and Behavioral Consequences
Authors: Luk Chung‐Leung , Wan Wendy W. N. , Chow Raymond P. M. , Chow Cheris W. C. , Fam Kim‐Shyan , Wu Peiguan , Kim Sarang 
Published: June 2012

ABSTRACTConsumers have three views about Feng Shui: instrumental, spiritual, and minimalist. According to the instrumental view, Feng Shui arrangements can affect luck and fortune. The spiritual view treats Feng Shui as part of one's spiritual life and cultural identification. The minimalist view dismisses Feng Shui as superstition. We developed psychometric scales for measuring these three views and the intention to make Feng Shui–related purchase, and conducted two studies to establish the reliability and validity of these scales. The participants in Study 1 were 331 university students; 180 working adults were the participants in Study 2. These three views of Feng Shui have different antecedents. Their effects on the intention to make Feng Shui–related purchase are also different. The effect of the instrumental view is positive and the strongest, but that of the spiritual view and the minimalist view is weakly positive and negative, respectively. The marketing implications of these findings are discussed. © 2012 Wiley Periodicals, Inc.
Influence of an experimental support on the estimation accuracy with artificial neural network
Authors: el Dsoki C. , Tomasella A. , Hanselka H. , Kaufmann H. 
Published: June 2012

AbstractWesentlich für die betriebsfeste Auslegung von Bauteilen sind geeignete Methoden und Übertragbarkeitskriterien sowie die Kenntnisse über das zyklische Werkstoffverhalten. Aus diesem Grund werden die zyklischen Werkstoffkennwerte in Abhängigkeit der Produkteigenschaften (Umformgrad, Gefüge, Oberflächenrauhigkeit, Eigenspannungen) und unterschiedlichen Belastungsparametern ermittelt. Da jedoch die Ermittlung der zyklischen Kennwerte mit hohen Versuchsaufwand und Kosten verbunden ist, wird nach Methoden gesucht, diese kostengünstig und schnell zu bestimmen. Ein viel versprechender Ansatz hierfür ist der Einsatz von künstlichen neuronalen Netzen (KNN), da sie in der Lage sind, die Einflüsse aus Fertigungs‐ und Umweltparametern auf die Schwingfestigkeit aus sinnvoll gewählten Eingangsparametern zu generieren. Sie bieten die Möglichkeit, auf erlerntes Wissen zurückzugreifen und somit, auf Basis weniger Versuche ein mehrdimensionales Kennfeld zu erstellen. Durch eine Kombination aus wenigen experimentellen Versuchen und dem künstlich neuronalen Netz kann die Treffsicherheit der Abschätzung erhöht und der erforderliche experimentelle Aufwand reduziert werden.
Chemical analysis of solid residue from liquid and solid fuel combustion: Method development and validation
Authors: Trkmić M. , Ćurković L. , Ašperger D. 
Published: June 2012

AbstractThis paper deals with the development and validation of methods for identifying the composition of solid residue after liquid and solid fuel combustion in thermal power plant furnaces. The methods were developed for energy dispersive X‐ray fluorescence (EDXRF) spectrometer analysis. Due to the fuels used, the different composition and the location of creation of solid residue, it was necessary to develop two methods. The first method is used for identifying solid residue composition after fuel oil combustion (Method 1), while the second method is used for identifying solid residue composition after the combustion of solid fuels, i. e. coal (Method 2). Method calibration was performed on sets of 12 (Method 1) and 6 (Method 2) certified reference materials (CRM). CRMs and analysis test samples were prepared in pellet form using hydraulic press. For the purpose of method validation the linearity, accuracy, precision and specificity were determined, and the measurement uncertainty of methods for each analyte separately was assessed. The methods were applied in the analysis of real furnace residue samples.
Rapid manufacturing of plastic aspheric optical lens
Authors: Kuo C.‐C. , Lin Z.‐Y. 
Published: June 2012

AbstractThis paper presents a new process to rapid manufacture the plastic aspheric optical lens. A bridge tooling was developed for fabricating the mold inserts of an aspheric lens using silicone rubber materials. Epoxy‐based composites were used to fabricate mold inserts of an aspheric optical lens. Z‐axis shrinkage error was investigated after plastic injection molding and compensated to the designed aspheric lens. In comparison with conventional method for fabricating a pair of mold inserts of a new plastic lens, a cost reduction of 75.02% and a time saving of 77.78% can be achieved. The deformation improvement percentage is about 92.48%. This technology can be used to compensate the z‐axis deformation efficiently due to shrinkage error of plastics in molding aspheric lens. Aspheric optical lens can be produced rapidly and cost‐effectively.
From soldering embrittlement to red shortness – commonalities and characteristics
Authors: Wittke K. , Scheel W. , Kising M. 
Published: June 2012

AbstractDer Lötbruch ist als lokale bzw. durchgängige Materialtrennung ein Lötfehler, der die Gewährleistung der Zuverlässigkeit von Lötverbindungen zeitlich stark einschränken kann oder sogar unmöglich macht. Diese Materialtrennung erfolgt in der Regel interkristallin entlang von Korngrenzen oder sogar Subkorngrenzen. Deshalb wird der Lötbruch makroskopisch den Sprödbrüchen im verfahrensbeeinflussten Grundwerkstoff der Lötverbindungen zugeordnet. Der Charakter der Lötbrüche und die Kinetik der Rissbildung ist u. a. mit ähnlichen Materialtrennungen wie z. B. Nebennahtrissen beim Schweißen und Rotbruch beim Umformen vergleichbar. Im vorliegenden Beitrag vergleichen die Autoren diese interkristallinen Materialtrennungen und beschreiben ihre Gemeinsamkeiten und auch Besonderheiten, wobei die Lötverbindungen im Mittelpunkt der Betrachtungen stehen.