bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic Analysis of Proximal Interphalangeal Joint Arthrodesis With an Intramedullary Fusion Device for Lesser Toe Deformities
Authors: Ellington J. Kent , Anderson Robert B. , Davis W. Hodges , Cohen Bruce E. , Jones Carroll P. 
Published: May 2010

Background: Lesser toe deformities are frequent and bothersome conditions. Many options exist for the treatment of hammertoes and clawtoes. The purpose of this study was to review our experience with the use of an intramedullary fusion device. Materials and Methods: An IRB approved retrospective review was performed to identify 38 toes in 27 patients treated with the StayFuse™ (Nexa Orthopaedics) device with a mean followup of 31 months. The indications for surgery were primary deformity in 12 toes and recurrent deformities in 26 toes. Results: Union occurred in 23 of 38 (60.5%). The union rate was nine of 12 for primary procedures and 53.8% (14/26) for revisions. Coronal PIP alignment demonstrated no change in 33 of 38 cases (86.8%) and changed in five of 38 (13.2%). Sagittal PIP alignment demonstrated no change in 36 of 38 cases (94.7%), and changed in 2/38 (5.3%). Including nonunion, the overall complication rate was 55.3% (21/38) (15 nonunions; three hardware failures (two (bent) not requiring intervention and one (broke) leading to a rotational deformity requiring revision), one intraoperative fracture (without sequelae), one requiring MP surgery, and one requiring a larger implant. The index surgery for all three of the patients that required a second surgery was for a recurrent deformity. All three patients requiring a second surgery occurred in the nonunion group. Conclusion: The StayFuse™ intramedullary fusion device was efficacious in maintaining PIP alignment in the treatment of lesser toe deformities with a relatively low reoperation rate at mid-term followup. Level of Evidence: IV, Retrospective Case Series
Chronic Plantar Fasciitis Treated with Two Sessions of Radial Extracorporeal Shock Wave Therapy
Authors: Ibrahim Mahmoud I. , Donatelli Robert A. , Schmitz Christoph , Hellman Madeleine A. , Buxbaum Frederick 
Published: May 2010

Background: Radial extracorporeal shock wave therapy (RSWT) has been previously demonstrated as an efficient treatment option for chronic plantar fasciitis (PF) when administered in three sessions. The present study tested the hypothesis that chronic PF can also be treated successfully with RSWT when only two treatment sessions are performed. Materials and Methods: A total of 50 patients with unilateral, chronic PF were randomly assigned to either RSWT ( n = 25) or placebo treatment ( n = 25). RSWT was applied in two sessions 1 week apart (2,000 impulses with energy flux density = 0.16 mJ/mm2 per session). Placebo treatment was performed with a clasp on the heel. Endpoints were changes in the Visual Analog Scale (VAS) score and the modified Roles & Maudsley (RM) score from baseline to 4 weeks, 12 weeks and 24 weeks followup. Results: Mean VAS scores were reduced after RSWT from 8.5 ± 0.3 (mean ± SEM) at baseline to 0.6 ± 1.5 at 4 weeks, 1.1 ± 0.3 at 12 weeks and 0.5 ± 0.1 at 24 weeks from baseline. Similar changes were found for mean RM scores from baseline after RSWT but were not observed after placebo treatment. Statistical analysis demonstrated that RSWT resulted in significantly reduced mean VAS scores and mean RM scores at all followup intervals compared to placebo treatment (each with p < 0.001). No serious adverse events of RSWT were observed. Conclusion: RSWT was successful in the treatment of chronic PF even when only two sessions with 2,000 impulses each were performed 1 week apart. Level of Evidence: I, Prospective Randomized Study
Arthroscopic Excision of Posterior Ankle Bony Impingement for Early Return to the Field: Short-term Results
Authors: Noguchi Hideo , Ishii Yoshinori , Takeda Mitsuhiro , Hasegawa Atsushi , Monden Satoshi , Takagishi Kenji 
Published: May 2010

Background: We treated 12 cases of posterior ankle bony impingement in 12 athletes arthroscopically, and examined the operating methods, findings, and postoperative physical therapy and overall results. Materials and Methods: The patients' average age was 21.4 years. The mean duration of postoperative followup was 33.8 months. A 2.7-mm, 30 degree arthroscope was inserted into the subtalar joint using posterolateral and accessory posterolateral portals. When the impinged fragment was visualized, it was carefully excised from the surrounding soft tissues. The operation was completed once the entire flexor hallucis longus tendon was seen. No cast immobilization was applied postoperatively, and physical therapy including limited weight bearing and range-of-motion exercises commenced within 24 hours after surgery. Beginning 3 weeks after surgery, the patients were permitted to gradually resume sports under the guidance of a physiotherapist. The AOFAS ankle-hindfoot score, the postoperative range of motion of the ankle and the time to recover were determined. Results: The average postoperative AOFAS ankle-hindfoot score improved from 68.0 to 98.3 points. The mean preoperative range of motion of the ankle joint was improved from 59.2 degree to 68.4 degree. The average period to return to sports was 5.9 weeks. All patients reached full activity within 13 weeks after surgery. The surgical time ranged from 40 minutes to over 2 hours and was affected by the impingement condition. Conclusion: Arthroscopic treatment for posterior ankle bony impingement syndrome was minimally invasive and suitable for athletes who desire an early return to sports activity. Level of Evidence: IV, Retrospective Case Series
Surgical Outcome Following Tibialis Anterior Tendon Repair
Authors: Ellington J. Kent , McCormick Jeremy , Marion Chad , Cohen Bruce E. , Anderson Robert B. , Davis W. Hodges , Jones Carroll P. 
Published: May 2010

Background: Tibialis anterior tendon rupture is an uncommon injury that can cause significant functional deficit. Recent series have supported surgical reconstruction in younger, more active patients. We investigated our clinical outcomes of patients having undergone surgical management of tibialis anterior tendon ruptures. Materials and Methods: Fifteen tibialis anterior tendon ruptures in 14 patients were retrospectively reviewed after surgical management. Five had primary repair, while 10 had tendon transfers. Average age at time of surgery was 70.6 years with an average followup of 27.2 months. Patients were evaluated with American Orthopaedic Foot and Ankle Society (AOFAS) and SF-36 clinical outcome scores. Strength measurements utilizing a dynamometer and range of motion (ROM) were documented on the operative and non-operative ankles. Patient satisfaction surveys were performed. Results: Average postoperative AOFAS hindfoot score was 88.8 and SF-36 score was 76.4. There was a statistically significant difference in average dorsiflexion strength of 21.8 lbs/in2 on the operative side and 28.8 lbs/in2 on the non-operative limb, and in dorsi-flexion ROM of patients that received a gastrocnemius recession. There was no statistically significant difference between primary tendon repair versus tendon transfer groups nor plan-tarflexion strength or ROM among any group. Patient surveys revealed that seven patients were completely satisfied, six had minor reservations, and one had major reservations. There were no complications. Conclusion: This study supports the surgical repair or reconstruction of the tibialis anterior tendon ruptures to restore functional strength and ROM. Level of Evidence: IV, Retrospective Case Series
Pain management of peritonsillar abscess
Authors: Choudhury A Allam , Sultana Tuhin , Alauddin M 
Published: May 2010

One year cross sectional study was undertaken in 50 patients with peritonsillar abscess to determine the treatment that was most effective in relieving the excruciating pain associated with the condition. The patients were divided into two treatment groups: intravenous antibiotic, and incision and drainage. The effect of treatment over was objectively assessed by serially measuring the distence between upper & lower incisor and by giving the patient water to drink at regular intervals to determine the point at which swallowing was pain-free. The improvement of the mean upper to lower incisor distance 15 minutes after the initial treatment was five per cent in the intravenous antibiotic group and 100 per cent in the incision and drainage group. None of the patients in the intravenous antibiotic group was able to swallow water two hours after the initial treatment. In the same time interval 23 patients (92 per cent) in the incision and drainage group were able to swallow water. The conclusion derived from this study is that incision and drainage is superior to intravenous antibiotic in relieving the pain associated with peritonsillar abscess. Key words: Peritonsillar Abscess, Pain. DOI: 10.3329/bjo.v14i1.3273 Bangladesh J of Otorhinolaryngology 2008; 14(1) : 6-8
Study on nodal metastasis in neck
Authors: Ahmad SM Mesbah Uddin , Huq AHM Zahurul , Joarder Md Abul Hasnat , Ahmed Abrar , Rahman Hasanur 
Published: May 2010

A cross sectional study was done in ENT Department, BSMMU from October 07 to March 08. An attempt has been made to evaluate metastatic neck node clinically. 60 cases were studied. Primary lesion identified in 53 cases (88.33%) and remain undetected in 7 cases (11.67%). Among primary sixty (60) diseases, 43 (81.13%) arises from upper aerodigestive tract which were squamous cell carcinoma & 10 (18.87%) came from thyroid & parotid gland. Commonest primary site was Larynx (36.67%). Majority (55%) of patients were age group 41-60. Unilateral lymph node was involved in 49 cases (81.67%), bilateral in 10 (16.67%), contra lateral in 1 case (1.66%), Single node in 22 (36.67%), Multiple in 38 (63.33%) cases. Size of the node >6cm was found in 24 cases (40%), 3-6cm in 20 cases (63.33%), <3cm in 16 cases (26.67%). Most of the involved nodes were in level- II. Key words: Metastatic neck node, primary tumour DOI: 10.3329/bjo.v14i1.3275 Bangladesh J of Otorhinolaryngology 2008; 14(1) : 15-22
Hypopharyngeal carcinoma: a clinical study
Authors: Aich Manilal , Joarder Md Abul Hasnat , Datta PG , Alauddin M 
Published: May 2010

A prospective study was carried out from 2001 to 2002 at Department of Otolaryngology and Head- Neck Surgery, BSMMU, DMCH, SSMC & Mitford Hospital, Dhaka. Data were collected from 45 patients with histologically diagnosed hypopharyngeal carcinoma on the following variables 1) sociodemographics, 2) clinical manifestations, 3) sub-sites of carcinoma, 4) clinical staging, 5) time of diagnosis, 6) associated risk factors, and 8) patients general performance status at presentation was determined by the Karnofsky scoring system. Results of this study showed that hypopharyngeal carcinoma affects fourth (60%) and fifth (26.7%) decade of life. It was found that male was highly predominant to develop hypopharyngeal carcinoma and ratio was 6:1. People with lower educational level and lower income group were found to be affected more by hypopharyngeal carcinoma. In this study the mean time elapsed from the appearance of the first symptom to the diagnosis of hypopharyngeal carcinoma was 4.11 months. This study found that the key symptom of hypopharyngeal carcinoma was dysphagia, pain, hoarseness and neck mass. 80 percent patient presented with palpable lymph node and all of them were in level II. Pyriform fossa was found to be the commonest site (80%) affected by carcinoma. In this series 75 percent patient presented in stage III and stage IV. There is strong relation between staging and diagnostic delay (p<0.05). In this study 86.7 percent patients had history of smoking. Smoking was found significantly associated with hypopharyngeal carcinoma (p<0.05). Betel nut chewing and tobacco chewing was found to be significant factors to develop hypopharyngeal carcinoma (p<0.05). This study showed that there was no patient with good oral health. Bad and average orodental hygiene was found in 44.4 and 55.6 percent respectively. Statistically bad oral hygiene was significantly related to hypopharyngeal carcinoma (p<0.05). Performance status of the patients at presentation was good and 77.8 percent of patients with hypopharyngeal carcinoma at diagnosis were capable of self-care. DOI: 10.3329/bjo.v14i1.3276 Bangladesh J of Otorhinolaryngology 2008; 14(1) : 23-29
Functional endoscopic sinus surgery for the management of sinonasal diseases
Authors: Saha Kanu Lal , Taous Ahmmad , Rahman Md Zillur 
Published: May 2010

This study was carried out to observe the role and outcome of endoscopic sinus surgery in the management of sinonasal disease. Study was done in department of ENT & Head-Neck Surgery, Dhaka Medical College, Dhaka from July 2002 to June 2004 (2 years). Sixty patients (60) were included retrospectively for this work. Main presenting symptoms of patients were nasal obstruction (78.33%), nasal discharge (73.33%), headache (51.66%) and recurrent sore throat (50%). In this series, minor complications occurred in 13.3% which includes synechiae, haemorrhage, infection and eccymosis of eye. No major complications like CSF leak, retroorbital haemorrhage, blindness were noted. Only 3 cases (5%) had severe haemorrohage. Most of the patients have got complete symptomatic relief, 5 cases had no improvement. It was concluded that functional endoscopic sinus surgery (FESS) has provided a safe and efficient method for dealing with different sinonasal disease and can be performed with high success rate for alleviation of symptoms with negligible morbidity. Key words: Functional endoscopic sinus surgery, sinonasal disease, complications. DOI: 10.3329/bjo.v14i2.3280 Bangladesh J of Otorhinolaryngology 2008; 14(2) : 46-50
Synchronous malignancy of left parotid gland and left eye ball - a case report
Authors: Rahman Md Mostafizur , Ahmed Khabir Uddin , Hassan Mahmudul , Atiquzzaman Kazi 
Published: May 2010

A 40 year old man was admitted to Shaheed Suhrawardy hospital, Dhaka with swelling of left parotid gland and left eye ball. Previously incisional biopsy was done from upper conjuntival swelling at National Institute of Opthalmology (NIO), Dhaka which revealed moderately differentiated Squamous cell carcainoma. Later on FNAC of left parotid swelling was done which revealed poorly differentiated adenocarcinoma. The patient under went left Radical Parotidectomy with left sided selective neck dissection and exenteration of left eye ball at SSH, Dhaka. Histopathology report showed poorly differentiated carcinoma of parotid, conjunctival tissues & necknodes. As synchronous malignancy of parotid gland, eyeball with metastatic neck nodes is rare, so this case has been selected to publish in the medical journal. Key words: Parotid, Eye ball, Synchronous Malignancy. Bangladesh J of Otorhinolaryngology 2008; 14(2) : 75-77
Caudal cervical arthrodesis using a distractable fusion cage in a dog
Authors: Bernard F. , Bardet J.-F. , da Silva Adrega 
Published: May 2010

SummaryThis case report describes a cervical fusion cage, surgical technique and the long-term outcome of caudal cervical arthrodesis used to stabilise dynamic spinal cord compression at the sixth and seventh cervical intervertebral disc space (C6, C7) in a dog. A seven-year-old, 41 kg, entire male Dobermann Pinscher was admitted for progressive ataxia of two weeks duration. Neurological examination revealed ambulatory tetraparesis. Computed tomographic myelogram scans in neutral and traction positions of the neck were performed and were used to determine presence of a dynamic component. A C6-C7 surgical distraction and stabilisation using a distractable intervertebral fusion cage was performed. There was not any deterioration of neurological status was observed on postoperative neurological evaluation. Within eight weeks after surgery, gait and postural abilities had returned to normal. Computed tomography evaluation indicated a complete bridging callus within and outside the cage at 15 weeks after surgery. There were not any complications or recurrences of initial neurological deficits observed during the 40 month follow-up period. Based on the follow-up period data, a C6-C7 dynamic spinal cord compression with disc protrusion was successfully treated by a distractable cervical fusion cage.
Avian kleptoparasitism of the digger wasp Sphex pensylvanicus
Authors: Benttinen Justin , Preisser Evan 
Published: May 2010

AbstractKleptoparasitism (one organism stealing prey from another) is especially common in birds. Avian kleptoparasites should be especially likely to target insects such as digger wasps (Hymenoptera: Sphecidae) that occur in large aggregations and repeatedly deliver large prey to the same nesting site. We document kleptoparasitism of digger wasps (Sphex pensylvanicus L.) by sparrows (Passer domesticus (L.)) and catbirds (Dumetella carolinensis (L.)). During summer 2008, we observed 697 wasp provisioning attempts (return of a prey-laden wasp to a marked nesting site) in a mown field. One-third (244/697) of attempts were intercepted by birds, primarily sparrows, which increased their hourly total number and hourly number of successful attacks per capita. Wasps maintained a consistent rate of successful provisioning attempts but may not have been able to do so indefinitely. Energetic costs related to kleptoparasitism may exert strong selection pressures on affected digger wasps.
Host selection and reproductive performance of Phloeosinus bicolor (Coleoptera: Curculionidae: Scolytinae) in indigenous and exotic Cupressus in Tunisia
Authors: Belhabib Raoudha , Lieutier François , Jamaa Mohamed Lahbib Ben , Nouira Said 
Published: May 2010

AbstractHost preferences and reproductive performance of the juniper bark beetle, Phloeosinus bicolor (Brulle), on logs from different parts of the bole of indigenous Cupressus sempervirens L. (Cupressaceae) and exotic C. arizonica Greene and C. sempervirens var. atlantica (Gaussen) Silba were experimentally studied in the field and laboratory in Tunisia. Attack densities were around 1/dm2 in the field, fecundity was 10 – 25 eggs per female’s gallery, with a sex ratio close to 1. There was no effect of cypress taxon or log category on host selection or attack parameters (attack density, density of systems, density of galleries, rate of successful attacks), although values for C. sempervirens tended to be higher than those for C. arizonica. Reproductive performance (gallery length and fecundity) was highest in C. arizonica and lowest in C. sempervirens var. atlantica, with C. sempervirens in an intermediate position; egg densities did not differ. Gallery length and fecundity showed a significant linear correlation but were lower in C. sempervirens var. atlantica than in the other two taxa. Thus there seems to be no relationship between host preference and host suitability in P. bicolor: its ability to choose and oviposit in various cypress taxa fits with its polyphagous status.
Parasitism of a successful weed biological control agent, Neogalerucella calmariensis
Authors: Norman Kathryn , Cappuccino Naomi , Forbes Mark R. 
Published: May 2010

AbstractWe investigated parasitism of the purple loosestrife beetle, Neogalerucella calmariensis (L.) (Coleoptera: Chrysomelidae), an introduced weed biological control agent, at 13 sites in eastern Ontario and western Quebec, Canada. Beetles were parasitized by gregarine gut protozoans (Apicomplexa: Eugregarinida) and much less commonly by nematodes (Nematoda: probably Mermithidae) and ectoparasitic mites (Acari: Erythraeidae). Female beetles had more gregarines than did males and the gregarine load was marginally higher in individuals from the original release sites than in individuals from recently colonized sites. Despite its overall success as a biological control agent, N. calmariensis harbours a substantial parasite load.
The Optimal Antigen Response of Chimeric Antigen Receptors Harboring the CD3ζ Transmembrane Domain Is Dependent upon Incorporation of the Receptor into the Endogenous TCR/CD3 Complex
Authors: Bridgeman John S. , Hawkins Robert E. , Bagley Steve , Blaylock Morgan , Holland Mark , Gilham David E. 
Published: May 2010

AbstractChimeric Ag receptors (CARs) expressed in T cells permit the redirected lysis of tumor cells in an MHC-unrestricted manner. In the Jurkat T cell model system, expression of a carcinoembryonic Ag-specific CD3ζ CAR (MFEζ) resulted in an increased sensitivity of the transduced Jurkat cell to generate cytokines when stimulated through the endogenous TCR complex. This effect was driven through two key characteristics of the MFEζ CAR: 1) receptor dimerization and 2) the interaction of the CAR with the endogenous TCR complex. Mutations of the CAR transmembrane domain that abrogated these interactions resulted in a reduced functional capacity of the MFEζ CAR to respond to carcinoembryonic Ag protein Ag. Taken together, these results indicate that CARs containing the CD3ζ transmembrane domain can form a complex with the endogenous TCR that may be beneficial for optimal T cell activation. This observation has potential implications for the future design of CARs for cancer therapy.
Small RNAs Guide Hematopoietic Cell Differentiation and Function
Authors: Navarro Francisco , Lieberman Judy 
Published: May 2010

Abstract
MicroRNAs (miRNAs) are key regulators of gene expression that help direct normal differentiation and malignant transformation of hematopoietic cells. This review summarizes our current knowledge of how miRNAs function in normal and malignant hematopoiesis and how miRNAs might be applied for disease treatment.
Transcription-Dependent Mobilization of Nucleosomes at Accessible TCR Gene Segments In Vivo
Authors: Kondilis-Mangum Hrisavgi D. , Cobb Robin Milley , Osipovich Oleg , Srivatsan Sruti , Oltz Eugene M. , Krangel Michael S. 
Published: May 2010

Abstract
Accessibility of chromosomal recombination signal sequences to the RAG protein complex is known to be essential for V(D)J recombination at Ag receptor loci in vivo. Previous studies have addressed the roles of cis-acting regulatory elements and germline transcription in the covalent modification of nucleosomes at Ag receptor loci. However, a detailed picture of nucleosome organization at accessible and inaccessible recombination signal sequences has been lacking. In this study, we have analyzed the nucleosome organization of accessible and inaccessible Tcrb and Tcra alleles in primary murine thymocytes in vivo. We identified highly positioned arrays of nucleosomes at Dβ, Jβ, and Jα segments and obtained evidence indicating that positioning is established at least in part by the regional DNA sequence. However, we found no consistent positioning of nucleosomes with respect to recombination signal sequences, which could be nucleosomal or internucleosomal even in their inaccessible configurations. Enhancer- and promoter-dependent accessibility was characterized by diminished abundance of certain nucleosomes and repositioning of others. Moreover, some changes in nucleosome positioning and abundance at Jα61 were shown to be a direct consequence of germline transcription. We suggest that enhancer- and promoter-dependent transcription generates optimal recombinase substrates in which some nucleosomes are missing and others are covalently modified.