bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary stability and self‐tapping blades: biomechanical assessment of dental implants in medium‐density bone
Authors: Kim Yung‐Soo , Lim Young‐Jun 
Published: February 2011

AbstractAim: The aim of this biomechanical study was to assess the influence of self‐tapping blades in terms of primary implant stability between implants with self‐tapping blades and implants without self‐tapping blades using five different analytic methods, especially in medium‐density bone.Materials and methods: Two different types of dental implants (4 × 10 mm) were tested: self‐tapping and non‐self‐tapping. The fixture design including thread profiles was exactly the same between the two groups; the only difference was the presence of cutting blades on one half of the apical portion of the implant body. Solid rigid polyurethane blocks with corresponding densities were selected to simulate medium‐density bone. Five mechanical assessments (insertion torque, resonance frequency analysis [RFA], reverse torque, pull‐out and push in test) were performed for primary stability.Results: Implants without self‐tapping blades showed significantly higher values (P<0.001) in four biomechanical assessments, except RFA (P=0.684). However, a statistically significant correlation could not be detected between insertion torque values with the four different outcome variables (P>0.05).Conclusions: The outcomes of the present study indicate that the implant body design without self‐tapping blades has a good primary stability compared with that with self‐tapping blades in medium‐density bone. Considering the RFA, a distinct layer of cortical bone on marginal bone will yield implant stability quotient values similar to those in medium‐bone density when implants have the same diameter.To cite this article:
Kim Y‐S, Lim Y‐J. Primary stability and self‐tapping blades: biomechanical assessment of dental implants in medium‐density bone. Clin. Oral Impl. Res. 22, 2011; 1179–1184. doi: 10.1111/j.1600‐0501.2010.02089.x
Effect of platform switching on peri‐implant bone levels: a randomized clinical trial
Authors: Enkling Norbert , Jöhren Peter , Klimberg Victoria , Bayer Stefan , Mericske‐Stern Regina , Jepsen Søren 
Published: February 2011

AbstractObjective: The concept of platform switching has been introduced to implant dentistry based on observations of reduced peri‐implant bone loss. However, randomized clinical trials are still lacking. This study aimed to test the hypothesis that platform switching has a positive impact on crestal bone‐level changes.Material and methods: Two implants with diameters of 4 mm were inserted epicrestally into one side of the posterior mandibles of 25 subjects. After 3 months of submerged healing, the reentry surgery was performed. On the randomly placed test implant, an abutment 3.3 mm in diameter was mounted, resulting in a horizontal circular step of 0.35 mm (platform switching). The control implant was straight, with an abutment 4 mm in diameter. Single‐tooth crowns were cemented provisionally. All patients were monitored at short intervals over the course of 1 year. Standardized radiographs and microbiological samples from the implants' inner spaces were obtained at baseline (implant surgery), and after 3, 4, and 12 months.Results: After 1 year, the mean radiographic vertical bone loss at the test implants was 0.53±0.35 mm and at the control implants, it was 0.58±0.55 mm. The mean intraindividual difference was 0.05±0.56 mm, which is significantly <0.35 mm (P=0.0093, post hoc power 79.9%). The crestal bone‐level changes depended on time (P<0.001), but not on platform switching (P=0.4). The implants' internal spaces were contaminated by bacteria, with no significant differences in the total counts between the test and the control at any time point (P=0.98).Conclusions: The present randomized clinical trial could not confirm the hypothesis of a reduced peri‐implant bone loss at implants restored according to the concept of platform switching.To cite this article:
Enkling N, Jöhren P, Klimberg V, Bayer S, Mericske‐Stern R, Jepsen S. Effect of platform switching on peri‐implant bone levels: a randomized clinical trial.  Clin. Oral Impl. Res. 22, 2011; 1185–1192. doi: 10.1111/j.1600‐0501.2010.02090.x
Fatigue in adult patients with primary immune thrombocytopenia
Authors: Newton Julia L. , Reese Jessica A. , Watson Shirley I. , Vesely Sara K. , Bolton‐Maggs Paula H. B. , George James N. , Terrell Deirdra R. 
Published: February 2011

AbstractBackground:  Patients with primary immune thrombocytopenia (ITP) commonly describe symptoms of fatigue. However, hematologists rarely consider fatigue a manifestation of ITP.Objectives:  To document the prevalence of fatigue among patients with ITP and to determine the patient characteristics that are associated with fatigue.Methods:  Using a cross‐sectional design, we surveyed 1871 members of the UK ITP Support Association [585 (31%) responded], and 93 patients enrolled in the Oklahoma (US) ITP Registry [68 (73%) responded] with questions about their ITP and with validated symptom assessment scales for fatigue, daytime sleepiness, and orthostatic symptoms.Results:  The prevalence of fatigue among both UK (39%) and US (22%) patients was significantly greater than expected compared with normal subjects (P < 0.0001 and P < 0.0001 respectively). In univariate analysis of the combined cohorts, fatigue was associated with a platelet count <100 000/μL, treatment with steroids, bleeding symptoms, presence of other medical conditions, daytime sleepiness, and orthostatic symptoms. Fatigue was not associated with age, gender, duration of ITP, or splenectomy status. Multivariate analysis of the combined cohorts was stratified for the presence or absence of bleeding symptoms. Among 107 patients with bleeding symptoms, fatigue was independently associated with a platelet count <100 000/μL and female gender. Among 491 patients without bleeding symptoms, fatigue was independently associated with a platelet count <30 000/μL, presence of other medical conditions, daytime sleepiness, and orthostatic symptoms.Conclusions:  Fatigue is a common symptom among patients with ITP. These data provide the basis for future studies to define the clinical importance of fatigue in ITP.
Analysis of CLLU1 expression levels before and after therapy in patients with chronic lymphocytic leukemia
Authors: Buhl Anne Mette , James Danelle F. , Neuberg Donna , Jain Sonia , Rassenti Laura Z. , Kipps Thomas J. 
Published: February 2011

AbstractObjective:  Chronic lymphocytic leukemia (CLL) is incurable, but therapy leading to eradication of minimal residual disease (MRD) in CLL is associated with improved clinical outcomes. CLL upregulated gene 1 (CLLU1) is solely upregulated in CLL patient samples. We hypothesized that CLLU1 could be used to monitor for residual disease in CLL patient samples after therapy.Methods:  We examined whether the CLLU1 real‐time quantitative PCR (RQ‐PCR) could detect small numbers of CLL cells in mixtures of normal peripheral blood mononuclear (PBMC) cells. We then performed a retrospective analysis on time‐matched cryo‐preserved specimens from patients who achieved MRD‐negative remissions that underwent serial marrow biopsies for evaluation of residual disease by 4‐color flow cytometry. RNA from PBMC samples collected at the time of the marrow assessments was analyzed for CLLU1. Nine patients underwent a total of 46 paired blood and marrow evaluations (median 5 assessments per patient).Results:  CLLU1 RQ‐PCR on PBMCs of healthy donors reconstituted with varying amounts of CLL cells demonstrated leukemia cells could be reliably detected with high sensitivities depending on the CLLU1 expression level. Analysis of time‐matched samples assessed for CLLU1 levels in the blood by RQ‐PCR and residual disease of the marrow determined by 4‐color flow cytometry revealed a correlation coefficient of 0.96 (P < 0.0001).Conclusion:  The CLLU1 RQ‐PCR is a sensitive and specific assay for detecting residual CLL cells after therapy. Assessment of blood CLLU1 levels can be used as a reliable marker of tumor burden and has the potential to complement currently used techniques for MRD monitoring in patients with CLL.
Marathon of eponyms: 16 Paget disease of bone
Authors: Scully C , Langdon J , Evans J 
Published: February 2011

Oral Diseases (2011) 17, 238–240The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry, oral and maxillofacial medicine, oral and maxillofacial pathology, oral and maxillofacial radiology and oral and maxillofacial surgery) and particularly by hospital‐centred practitioners. This series has selected some of the more recognised relevant eponymous conditions and presents them alphabetically. The information is based largely on data available from MEDLINE and a number of internet websites as noted below: the authors would welcome any corrections. This document summarises data about Paget disease of bone.
Antimicrobial activity of disinfectant agents incorporated into type IV dental stone
Authors: de Paula Pereira Rodrigo , Lucas Matheus Guilherme , Spolidorio Denise Madalena Palomari , Filho João Neudenir Arioli 
Published: February 2011

doi: 10.1111/j.1741‐2358.2011.00462.x

Antimicrobial activity of disinfectant agents incorporated into type IV dental stonePurpose:  This study evaluated the antimicrobial activity of two disinfectant agents, 2% chlorhexidine digluconate solution (CHX) and 98% chlorhexidine hydrochloride powder (HYD), incorporated into type IV dental stone at the time of mixing.Material and methods:  Agar diffusion test was used for the following microorganisms: Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Candida albicans. The specimens were grouped in: (1) dental stone mixed with sterile distilled water; (2) paper disc soaked with CHX; (3) dental stone mixed with CHX; and (4) dental stone with incorporation of HYD, in 1% proportion of the dental stone mass and mixed with sterile distilled water. The culture medium was inoculated with microbial suspensions 1 and 24 h after pouring of the dental stone. The antimicrobial activity was evaluated by the average diameter of microbial growth inhibition zones. The data were analysed with a nested anova (p < 0.05) and Tukey test for specific comparisons.Results:  The disinfectant agents demonstrated antimicrobial activity against all microorganisms, with the exception of C. albicans, against which the CHX was ineffective in two periods of analysis. Significant differences between disinfectants were found with all microorganisms.Conclusion:  The disinfectant agents analysed were effective against most of the microorganisms tested, except C. albicans.
Anion Responsive Dibenzoyl‐l‐Cystine and Luminescent Lanthanide Soft Material
Authors: Zheng Yuhui , Li Yan , Tan Chaoliang , Wang Qianming 
Published: February 2011

AbstractA mild sol–gel technique was used to incorporate terbium dibenzoyl‐l‐cystine complex into silica and green luminescent hybrid material was fabricated. 1H NMR and fluorescence spectroscopy revealed the hybrids can recognize F− anions through hydrogen bonding formation and had no sense in binding other halide or HSO4−. Furthermore, a luminescent hydrogel was successfully designed by immobilizing a terbium activated phosphor (Gd0.1Ce0.9PO4:Tb) into molecular hydrogelator (dibenzoyl‐l‐cystine). The Tb(III) emission in hydrogel media gave a distinguished enhancement based on temperature increase and the function conforms to exponential equation y = 1160.6 exp0.03x. The stability of the green luminescent gel was rather excellent and the reversibility of the gel can be recycled at least five times.
Receptor tyrosine kinases and their activation in melanoma
Authors: Easty David J. , Gray Steven G. , O’Byrne Kenneth J. , O’Donnell Dearbhaile , Bennett Dorothy C. 
Published: February 2011

SummaryReceptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression studies and detection of activated RAS isoforms in a small fraction of melanomas. Predictions that overexpression of specific RTKs implied increased kinase activity and that some RTKs would show activating mutations in melanoma were largely untested. However, technological advances including rapid gene sequencing, siRNA methods and phospho‐RTK arrays now give a more complete picture. Mutated forms of RTK genes including KIT, ERBB4, the EPH and FGFR families and others are known in melanoma. Additional over‐ or underexpressed RTKs and also protein tyrosine phosphatases (PTPs) have been reported, and activities measured. Complex interactions between RTKs and PTPs are implicated in the abnormal signalling driving aberrant growth and survival in malignant melanocytes, and indeed in normal melanocytic signalling including the response to ultraviolet radiation. Kinases are considered druggable targets, so characterization of global RTK activity in melanoma should assist the rational development of tyrosine kinase inhibitors for clinical use.
Patent Foramen Ovale—Assessment and Treatment
Authors: Irwin Bruce , Ray Simon 
Published: February 2011

SUMMARYA Patent Foramen Ovale (PFO) is detectable in 20–25% of the population. Some, but not all, case control studies have found an increased incidence of PFO in patients with cryptogenic stroke. Prospective cohort studies have failed to convincingly demonstrate a link between PFO and first stroke, and evidence linking PFO to recurrent stroke is far from compelling. The rate of recurrent stroke in medically treated patients is low, but the development of devices for PFO closure has lead to enthusiasm in some quarters to pursue a strategy of device closure. Nonrandomized studies have suggested a lower risk of recurrent events with device closure but the data are heterogeneous, and potentially prone to bias. Device implantation is associated with a risk of major adverse events of between 1.5% and 2.3%, and there is a significant rate of failure to close shunts. The results of randomized trials of device closure are keenly awaited. Migraine with aura has been linked with PFO. A recent metanalysis suggested an association, but the one prospective population study did not. The well‐publicized and controversial MIST Trial is the only randomized trial of device closure in migraineurs yet published, and failed to demonstrate a convincing benefit from device closure. Other conditions such as platypnea‐orthodeoxia syndrome and prevention of decompression sickness in divers, may justify device closure. Evidence for a role of PFO in the etiology of cryptogenic stroke and migraine is contradictory. It is possible that some patients might benefit from PFO closure but there is scant evidence of sufficient quality to justify routine PFO closure in either group. It is essential that ongoing randomized trials of device closure are completed.
Microembolic Signals and Aspirin Resistance in Patients with Carotid Stenosis
Authors: Dawson Jesse , Quinn Terry , Lees Kennedy R. , Walters Matthew R. 
Published: February 2011

SummaryIntroduction and AimsAspirin resistance may be linked to increased risk of cardiovascular events. We aimed to evaluate whether it was associated with presence of microembolic signals (MES), a readily measurable marker of increased stroke risk, in those with internal carotid artery (ICA) disease.MethodsWe studied patients with significant ICA disease who were compliant with aspirin therapy. We performed monitoring for MES and measured aspirin resistance status, using the platelet function analyzer (PFA)‐100 and Verify‐Now systems. We compared frequency of aspirin resistance between patients with and without MES and assessed agreement between the different platelet function tests.ResultsWe recruited 62 patients. Most (53, 85.5%) had symptomatic carotid disease and 16 (25.8%) had MES. The rate of aspirin resistance on at least one test was 25.8% (16 patients), with 13 (21%) resistant on PFA‐100 testing, 8 (12.9%) using the Verify‐Now system and 5 (8.1%) resistant on both. Aspirin resistance was more common in patients with MES (50% compared to 17.4% without, P= 0.018 on Fisher's exact test). Agreement between the platelet function tests was moderate (к= 0.41).ConclusionAspirin resistance appears more common in patients with carotid disease who have MES compared to those without. Further work should aim to establish whether screening for aspirin resistance and subsequent adjustment to antiplatelet therapy reduces the rate of MES and stroke risk in those with carotid disease.
Antimicrobial Susceptibility of Canine and Human Staphylococcus aureus Collected in Saskatoon, Canada
Authors: Rubin J. E. , Chirino‐Trejo M. 
Published: February 2011

SummaryStaphylococcus aureus is one of the most common causes of infection in people and is increasingly recognized in dogs. The increasing prevalence of methicillin resistant S. aureus (MRSA) is complicating the treatment of these infections. Panton Valentine leukocidin (PVL), a toxin involved in the pathogenesis of necrotic syndromes in people may be partially responsible for the rise of MRSA. Canine and human S. aureus from the same geographic area are genetically similar, indicating a common population and likely transmission. The implications of increasing antimicrobial resistance complicated by interspecies transmission, necessitates including both dogs and humans in S. aureus resistance surveillance studies. A collection of 126 S. aureus isolates from people (n = 99) and dogs (n = 27) were included, minimum inhibitor concentrations to a panel of 33 antimicrobials used in human and veterinary medicine were determined. No resistance to vancomycin, linezolid, daptomycin, quinupristin/dalfopristin or nitrofurantoin was found. A wide range of antibiograms were found; including resistance to 0–12 drugs (0–6 drug classes). Outstanding antibiograms included a canine MRSA resistant to rifampin and a human MRSA resistant to chloramphenicol. Inducible clindamycin resistance was found among 78% and 4% of canine and human MRSA and 17% and 25% of canine colonizing and human methicillin susceptible S. aureus (MSSA), respectively. Resistance to mupirocin was only found among human isolates including 20% of MRSA and 4% of MSSA. While no canine isolates were PVL positive, 39% of human MRSA and 2% of MSSA carried the gene. The bidirectional transmission of S. aureus between people and dogs necessitates the inclusion of isolates from both species in future studies.
Patterns of Rabies Occurrence in Bhutan between 1996 and 2009
Authors: Tenzin  , Dhand N. K. , Ward M. P. 
Published: February 2011

SummaryThis study was conducted to evaluate incidence and seasonal trends of rabies in dogs and other domestic animals in Bhutan from 1996 to 2009. Time series analysis approach was used to determine the seasonal trend and temporal association between species‐specific rabies cases in animals. A total of 814 rabies cases were reported during the 14‐year period, of which cattle and domestic dogs accounted for 55% (447/814) and 39% (317/814) of the cases, respectively. The remaining 6% of the cases (50/814) were reported in horses (2%), cats (2%), pigs (1%) and goats (1%). Rabies cases were reported throughout the year with more reports during spring and summer months. The annual patterns of cases were stable from 1996 to 2005, but the incidence increased during 2006 and 2008. Fifty‐nine of the 205 sub‐districts reported rabies in animals from 1996 to 2009 with increased incidences in the four districts in southern Bhutan, an area located close to the border towns of India. A significant (P < 0.05) positive cross‐correlation was observed between the number of cases in dogs and other domestic animals at time lags (months) 1–3 with the highest correlation (r = 0.94,P < 0.05) observed at time lag 0 (same month) indicating that the peak in rabies incidences occur in the same month when both dogs and other domestic animal cases are reported. Regression analysis predicted rabies in other domestic animal when there are reports of rabies in dogs during the previous months. This study provides useful information about the epidemiology of rabies that can be used to plan a rabies control programme in Bhutan.
Does music therapy reduce pain and anxiety in children with cancer undergoing lumbar puncture?
Authors: Vohra S , Nilsson S 
Published: February 2011

Nguyen TN, Nilsson S, Hellstrom A, Bengtson A. Music therapy to reduce pain and anxiety in children with cancer undergoing lumbar puncture: a randomized clinical trial. J Pediatr Oncol Nurs 2010; 27:146–55.
Hochu‐ekki‐to reduces demand for topical steroids and tacrolimus in atopic dermatitis patients with Kikyo (delicate constitution)
Authors: Clement Y 
Published: February 2011

Kobayashi H, Ishii M, Takeuchi S, Tanaka Y, Shintani T, Yamatodani A, Kusunoki T, Furue M. Efficacy and safety of a traditional herbal medicine, Hochu‐ekki‐to, in the long‐term management of Kikyo (delicate constitution) patients with atopic dermatitis: a 6‐month, multicenter, double‐blind, randomized, placebo‐controlled study. Evid Based Complement Alternat Med 2010; 7: 367–73. doi:10.1093/ecam/nen003
Designing an RCT to assess the effectiveness of a nutritional intervention after hip surgery
Authors: Rannou F 
Published: February 2011

Wyers CE, Breedveld‐Peters JJL, Reijven PLM, van Helden S, Guldemond NA, Severens JL, Verburg AD, Meesters B, van Rhijn LW, Dagnelie PC. Efficacy and cost‐effectiveness of nutritional intervention in elderly after hip fracture: design of a randomized controlled trial. BMC Public Health 2010; 10: 212.
The success of acupuncture depends on the communication style
Authors: Ernst E 
Published: February 2011

Suarez‐Almazor ME, Looney C, Liu Y, Cox V, Pietz K, Marcus DM, Street RL Jr. A randomized controlled trial of acupuncture for osteoarthritis of the knee: effects of patient‐provider communication. Arthritis Care Res 2010; 62: 1229–36.
Green’s conjecture for curves on arbitrary K3 surfaces
Authors: Aprodu Marian , Farkas Gavril 
Published: February 2011

AbstractGreen’s conjecture predicts than one can read off special linear series on an algebraic curve, by looking at the syzygies of its canonical embedding. We extend Voisin’s results on syzygies of K3 sections, to the case of K3 surfaces with arbitrary Picard lattice. This, coupled with results of Voisin and Hirschowitz–Ramanan, provides a complete solution to Green’s conjecture for smooth curves on arbitrary K3 surfaces.
Base change for semiorthogonal decompositions
Authors: Kuznetsov Alexander 
Published: February 2011

AbstractLet X be an algebraic variety over a base scheme S and ϕ:T→S a base change. Given an admissible subcategory 𝒜 in 𝒟b(X), the bounded derived category of coherent sheaves on X, we construct under some technical conditions an admissible subcategory 𝒜T in 𝒟b(X×ST), called the base change of 𝒜, in such a way that the following base change theorem holds: if a semiorthogonal decomposition of 𝒟b (X) is given, then the base changes of its components form a semiorthogonal decomposition of 𝒟b (X×ST) . As an intermediate step, we construct a compatible system of semiorthogonal decompositions of the unbounded derived category of quasicoherent sheaves on X and of the category of perfect complexes on X. As an application, we prove that the projection functors of a semiorthogonal decomposition are kernel functors.
Cohomology of quiver moduli, functional equations, and integrality of Donaldson–Thomas type invariants
Authors: Reineke Markus 
Published: February 2011

AbstractA system of functional equations relating the Euler characteristics of moduli spaces of stable representations of quivers and the Euler characteristics of (Hilbert-scheme-type) framed versions of quiver moduli is derived. This is applied to wall-crossing formulas for the Donaldson–Thomas type invariants of M. Kontsevich and Y. Soibelman, in particular confirming their integrality.