bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the fusion of virtual fitting rooms and social media: a study on consumer behaviour and purchase intentions
Authors: Konale Madhura , Panakaje Niyaz , Parvin S. M. Riha , Kulal Abhinandan , Kambali Ujwala 
Published: February 2025

PurposeIn the evolving digital landscape, customers connect with the diversified digital marketing platforms, posing both obstacles and opportunities to consumers. In response to the changing landscape of social media and technical advances within the fashion business, the study aims to investigate the role of virtual fitting rooms in influencing consumer behaviour and purchase intentions through social media, with respect to fashion products.Design/methodology/approachThe study used a combination of primary and secondary data, relying on secondary sources to identify research gaps and construct the conceptual framework and a survey-based approach enabled the collection of 352 responses from metropolitan cities of India like Bangalore, Chennai, Kolkata and New Delhi using snowball sampling for studying research variables. The hypothetical relationships were tested using various statistical techniques such as multiple regression analysis, measurement model assessment using confirmatory factor analysis and structural equation modeling (SEM).FindingsThe present study connects the dots between social media, virtual fitting rooms, engagement characteristics, buying intentions and consumer purchasing behaviour by manifesting a positive association with engagement metrics that correspond to the current user-behaviour pattern. As per results, virtual fitting rooms are significantly associated with effectiveness of social media. Moreover, social media as a mediator significantly amplifies the impact of virtual fitting rooms on the intents and behaviour of consumers while making purchases.Originality/valueResearch spotlights the novel findings (i.e. interactive, visual, personalized shopping moments and social capabilities features) of social media in enhancing the interaction with virtual fitting rooms, which shapes the fashion purchasing decisions.
Proteasome Augmentation Mitigates Age‐Related Cognitive Decline in Mice
Authors: Parker Danitra , Davidson Kanisa , Osmulski Pawel A. , Gaczynska Maria , Pickering Andrew M. 
Published: February 2025

ABSTRACTThe aging brain experiences a significant decline in proteasome function. The proteasome is critical for many key neuronal functions including neuronal plasticity, and memory formation/retention. Treatment with proteasome inhibitors impairs these processes. Our study reveals a marked reduction in 20S and 26S proteasome activities in aged mice brains, including in the hippocampus, this is driven by reduced functionality of aged proteasome. The decline in proteasome activity is matched by a decline in 20S proteasome assembly. In contrast, 26S proteasome assembly was found to increase with age, though 26S proteasome activity was still found to decline. Our data suggests that age‐related declines in proteasome activity is driven predominantly by reduced functionality of proteasome rather than altered composition. By overexpressing the proteasome subunit PSMB5 in the neurons of mice to increase the proteasome content and thus enhance its functionality, we slowed age‐related declines in spatial learning and memory. We then showed acute treatment with a proteasome activator to rescue spatial learning and memory deficits in aged mice. These findings highlight the potential of proteasome augmentation as a therapeutic strategy to mitigate age‐related cognitive declines.
Participation in the National Cervical Screening Program Among Women Who Gave Birth in New South Wales, Australia by Place of Maternal Birth: A Data Linkage Analysis
Authors: Yuill Susan , Smith Megan A. , Velentzis Louiza S. , Nisha Monjura , Saville Marion , Kliewer Erich V. , Bateson Deborah , Canfell Karen 
Published: February 2025

ABSTRACTObjectiveHigh participation rates in the National Cervical Screening Program (NCSP) by all groups of women are required to ensure the equitable elimination of cervical cancer in Australia. In this study, we examine screening participation of overseas‐born women compared to Australian‐born women who gave birth.DesignPopulation‐based retrospective cohort study using linked health datasets.Setting and ParticipantsWomen who gave birth in New South Wales between January 1, 2000 and June 30, 2017.Main Outcome MeasuresParticipation in the NCSP (≥ 1 cytology test) in the 3‐ and 5‐year periods prior to delivery by place of maternal birth, adjusted for multiple socio‐demographic and health characteristics.ResultsAmong the 1 332 669 mothers who gave birth over the study period, overall cervical screening participation in the 3‐ and 5‐year periods prior to delivery was 67.0% and 75.7%, respectively. Participation was lower for overseas‐born mothers compared to Australian‐born mothers for both the 3‐year (57.8% vs. 71.7%; adjusted odds ratio [aOR]: 0.51, 95% confidence interval [CI]: 0.50–0.51) and 5‐year (64.9% vs. 81.2%; aOR: 0.40, 95% CI: 0.40–0.40) participation periods. All groups of overseas‐born women had substantially lower screening participation compared to Australian‐born women, with the lowest relative 3‐year participation in mothers born in Southern/Central Asia (aOR: 0.30, 95% CI: 0.30–0.31), Oceania (aOR: 0.31, 95% CI: 0.30–0.32), North‐East Asia (aOR: 0.49, 95% CI: 0.48–0.50), and New Zealand (aOR: 0.49, 95% CI: 0.48–0.51).ConclusionsOverseas‐born women had around half the cervical screening participation in the period prior to birth compared to Australian‐born women. It is likely that opportunities to screen these under‐screened groups during the antenatal period, typically a time of repeated health services contact, are missed.
Clinical and Histopathological Insights Into Lupus Miliaris Disseminatus Faciei: A Review of 70 Cases
Authors: Nasimi Maryam , Bandani Saba , Kamyab Kambiz , Etesami Ifa , Montazeri Sahar , Saberi Fatemeh , Babaie Hanie 
Published: February 2025

ABSTRACTBackgroundLupus miliaris disseminatus faciei (LMDF) is a granulomatous inflammatory disease often manifesting on the face as red, brown, or yellow papules. Lesions can cause scarring and disfigurement. There is no standard treatment due to a limited understanding of the etiology.MethodThis review examines the clinical and histopathological characteristics of 70 LMDF patients who were diagnosed from 2016 to 2022.ResultsThe patients' mean age was 32.43, with a majority being in their 20s and 30s. Females were more affected during the fourth decade and beyond. The average disease duration among patients was 7.2 months. All of them had facial involvement, mostly around the eyes and on the eyelids. Histopathological analysis revealed epithelioid granulomas with inflammatory cell infiltration and, in some cases, central caseous necrosis. A relationship between the granuloma and the pilosebaceous unit was seen in 75.7% of cases. Epidermal changes, like acanthosis, were found in 47.1% of cases. We also report the existence of linear vessels in 25 (35.7%) cases.ConclusionMost authors now consider LMDF a distinct entity, but because of its resemblance to other diseases like granulomatous rosacea, the diagnosis is challenging. Unlike many studies in this field, we provide a quite large sample and report telangiectasia in LMDF patients, which highlights the importance of precisely differentiating LMDF from rosacea. Delay in diagnosis and treatment increases the risk of scarring.Overall, we believe this study provides valuable insights into the demographics and histopathology of LMDF, contributing to the understanding of this challenging skin disorder.
Research in practice: Immune checkpoint inhibitor related autoimmune bullous dermatosis
Authors: Pruessmann Jasper N. , Pruessmann Wiebke , Sadik Christian D. 
Published: February 2025

SummaryImmune checkpoint receptors and ligands such as cytotoxic T lymphocyte antigen‐4 (CTLA‐4), programmed death‐1 (PD‐1) and ligand‐1 (PD‐L1) are widely expressed on immune and non‐immune cells and fine tune the activation level of immune cells, thus, enabling, preventing, or terminating immune responses. Blockade of CTLA‐4, PD‐1 or PD‐L1 by checkpoint inhibitors (CIs), unleashing immune responses, has become a mainstay in the treatment of diverse types of cancer. The induction of autoinflammatory, yet unspecific tissue damage in diverse organs is called an immune related adverse event (irAE), a class side‐effect of CIs and may require the discontinuation of immunotherapy. Among frequent skin rashes, CIs targeting the PD‐L1/PD‐1 axis can elicit the IgG autoantibody‐ and granulocyte‐driven bullous pemphigoid (BP) in about 0.3% to 0.6% of treated patients. Pathogenesis of BP requires a complex cellular inflammatory response after anti‐BP180 autoantibody binding to the dermal epidermal junction. The prevalence of autoantibodies against BP180 in healthy blood donors of approximately 0.52% equals the prevalence of irBP among treated cancer patients, underlining the potential relevance of the PD‐1 mediated regulation of tissue inflammation for spontaneous BP. If skin rashes appear during CI therapy, biopsies should be taken and examined by histopathological and direct immunofluorescence microscopy.
Regional Representation in the European Parliament: Parliamentary Questions on Geographical Indications
Authors: Huysmans Martijn , Gheyle Niels 
Published: February 2025

ABSTRACTThe European Parliament represents the citizens of the European Union. However, individual Members of the European Parliament (MEPs) also face incentives to represent more narrow regional economic interests. Geographical Indications (GIs) such as Asiago or Champagne are an ideal policy area to study regional representation. Their defined regions provide clear incentives and a reliable measurement of regional representation. This article codes and analyses the written questions on GIs posed by MEPs during the period 2009–2019. Descriptively, we find that MEPs often mention products from their region. We also find that MEPs focus their questions on contentious products and on politicized free trade agreements. Contributing to the debate on representation in the European Parliament, we find evidence for more regional representation by MEPs from countries with regional lists for EP elections. We conclude with the implications of our research for representation in the European Union and the idea of transnational lists.
Differential Risk Factors for Early Intravesical Recurrence After Radical Nephroureterectomy for Upper Urinary Tract Carcinoma According to the History of Non‐Muscle Invasive Bladder Cancer
Authors: Shindo Tetsuya , Ueki Yohei , Muranaka Ippei , Kobayashi Genki , Miyamoto Shintaro , Kunishima Yasuharu , Sato Shunsuke , Okada Manabu , Kato Shuichi , Kato Ryuichi , Adachi Hideki , Matsukawa Masanori , Takayanagi Akio , Ito Naoki , Wanifuchi Atsushi , Maehana Takeshi , Kyoda Yuki , Hashimoto Kohei , Kobayashi Ko , Tanaka Toshiaki , Masumori Naoya 
Published: February 2025

ABSTRACTObjectivesTo evaluate the preoperative risk factors for early intravesical recurrence after radical nephroureterectomy (RNU) in patients with upper urinary tract carcinoma (UTUC) according to the history of non‐muscle invasive bladder cancer (NMIBC).MethodsWe retrospectively evaluated patients who underwent RNU for UTUC between 2012 and 2022 at 14 hospitals. Early recurrence was defined as intravesical pathologically confirmed recurrence within 1 year after RNU. Patients who received single‐dose immediate intravesical instillation (IVI) as prevention for intravesical recurrence were excluded. Using preoperative factors, we examined the risk factors for early intravesical recurrences in patients with and without a history of NMIBC. Death from any cause within 1 year after RNU was regarded as a competitive risk.ResultsWe included 504 UTUC patients who were treated with RNU. Among these patients, 126 (25.0%) had a history of NMIBC, whereas 378 (75%) did not. According to multivariate analysis, the presence of macrohematuria, positive cytology in self‐voided urine, and performing diagnostic ureteroscopy prior to RNU were risk factors in patients without a history of NMIBC. On the other hand, an NMIBC diagnosis within 1 year prior to RNU and an extravesical approach for bladder cuff management were risk factors in RNU‐treated patients with a history of NMIBC.ConclusionsEarly intravesical recurrence risk factors differ between UTUC patients with and without a history of NMIBC. Different stratification may be needed to predict intravesical recurrence risk in these two types of UTUC patients.
MetS‐Z: A gender‐ and age‐specific scoring system for predicting type 2 diabetes
Authors: Hsu Paul Wei‐Che , Chen Yi‐Rong , Sheu Wayne Huey‐Herng 
Published: February 2025

ABSTRACTAimsCurrent metabolic syndrome (mets) criteria often lack consideration for age and gender differences. This study introduces the mets‐Z score, a novel tool designed to enhance mets assessment and improve long‐term outcome predictions.Materials and MethodsThe mets‐Z score was developed using principal component analysis (PCA) to weight five mets indicators—waist circumference, blood glucose, blood pressure, high‐density lipoprotein (HDL) cholesterol, and triglycerides—by gender and age. Data from 188,739 Taiwan Biobank participants, stratified by gender and age groups (20–39, 40–54, 55–64, 65+ years), were analyzed. Predictive performance for type 2 diabetes mellitus onset was assessed over a 4‐ to 5‐year follow‐up.ResultsThe mets‐Z score achieved superior accuracy in predicting type 2 diabetes mellitus onset, with an AUC of 0.76 in men and 0.80 in women, significantly outperforming conventional indices (P < 0.0001).ConclusionsBy integrating age‐ and gender‐specific variations, the mets‐Z score provides a more personalized and precise tool for assessing metabolic and diabetes risk, surpassing existing methods. The tool is available for public use at http://bioinfolab.nhri.edu.tw/metsz/, supporting broader applications in precision medicine.
Preschool Teacher Training on Neurodevelopmental Concerns in Children: A Pilot Study
Authors: Hamaguchi Masako , Kitazoe Noriko , Fukunaga Ichiro , Gillberg Christopher 
Published: February 2025

AbstractPreschool teacher training (TT) about children's neurodevelopmental concerns consisted of six monthly workshops and one booster session 3 months after the sixth session that lasted 90–105 min each. Each teacher was responsible for one child and provided different interventions between sessions. A questionnaire was administered pre‐ and post‐workshop. Of the 46 participants, we analyzed the results of 44. The Total Deviance/Difficulties score on the Strengths and Difficulties Questionnaire (SDQ) for children decreased significantly post‐training, with a large effect size. The SDQ subscale scores revealed larger effect sizes for Peer Problems and Prosocial Behavior and medium effect sizes for Hyperactivity and Emotional Symptoms. Teachers' Rosenberg Self‐Esteem Scale scores increased significantly with a medium effect size. The Pre‐School Teacher Efficacy Scale showed no significant differences with a small effect size. Thus, TT may benefit both children's behavior and teacher's self‐esteem. However, it is unclear whether these changes are attributable to actual changes in the children's or teachers' understanding of their growth and development, or to both. Further studies are required to confirm these findings.
Antinomies of Alignment Redux: The United Arab Emirates and the United States
Authors: Lawson Fred H. , Legrenzi Matteo 
Published: February 2025

AbstractOver the past three decades, the United Arab Emirates has forged a sturdy bilateral security alignment with the United States. It has also pursued foreign policies that conflict with US interests in the Gulf and the broader Middle East. This contradiction is usually attributed to a hedging strategy. However, a more accurate analysis indicates that this reflects the peculiar type of alignment that exists between the two countries: a dyadic protectorate. Protectorates exhibit a tendency toward obsolescence, which gives the protected state both the incentive and the capacity to assert its self‐interests. Protectors have little incentive to block such activism, partly because countermeasures are costly and partly because they tend to be counterproductive. Recent trends in UAE‐US relations evidence the willingness and ability of a protected state to push the limits of a dyadic protectorate, but only after the alignment obsolesces.
Different Transcriptome Signatures of the Lymphatic and the Blood Vessels From Rat Mesentery Reveal Distinct Function Characteristics
Authors: Jing Yumeng , Zhai Jiayi , Gao Min , Xu Xiu , Zhao Zi‐Gang , Zhao Zhen‐Ao 
Published: February 2025

ABSTRACTObjectiveLymphatic vessels and blood vessels have some similarities in structure, but they have distinct contraction characteristics and functions. Revealing the detailed transcriptional differences of lymphatic, artery and vein are required for circulation research.MethodsThe tissues of the mesenteric lymphatic, artery, and vein were collected from Wistar rats. The transcriptome signatures of these tissues from RNA‐seq (RNA sequencing) were analyzed using bioinformatic methods.ResultsGO (gene ontology) enrichment showed the three tissues have distinct gene expression patterns in extracellular matrix, cell adhesion molecule binding, receptor ligand activity, and contractile fiber. The genes involved in cell contractility were also differently expressed, which were enriched into the KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways of cytoskeleton in muscle cells, vascular smooth muscle contraction, and renin‐angiotensin system. Through PPI (protein–protein interaction) analysis, we identified 43 differently expressed hub genes in the three tissues. Thirty‐four transcription factors and cofactors were identified as important for the normal function of the three tissues. Furthermore, we screened out 20 potential marker genes for each tissue.ConclusionsOur study described the transcriptome signatures of mesenteric lymphatic, artery, and vein, shedding light on the distinct contraction mechanisms of these tissues. These results also provided potential therapeutic targets for circulation diseases and potential markers for lymphatic and blood vessel studies.
The chromosome‐scale assembly of the Salvia plebeia genome provides insight into the biosynthesis and regulation of rosmarinic acid
Authors: Dai Yiqun , He Mengqian , Liu Hui , Zeng Huihui , Wang Kaixuan , Wang Rui , Ma Xiaojing , Zhu Yan , Xie Guoyong , Zhao Yucheng , Qin Minjian 
Published: February 2025

SummarySalvia plebeia is an important traditional Chinese medicinal herb, with flavonoids and phenolic acids as its primary bioactive components. However, the absence of a reference genome hinders our understanding of genetic basis underlying the synthesis of these components. Here, we present a high‐quality, chromosome‐scale genome assembly of S. plebeia, spanning 1.22 Gb, with a contig N50 of 91.72 Mb and 36 861 annotated protein‐coding genes. Leveraging the genome data, we identified four catalytic enzymes—one rosmarinic acid synthase (RAS) and three cytochrome P450 monooxygenases (CYP450s) —in S. plebeia, which are involved in rosmarinic acid biosynthesis. We demonstrate that SpRAS catalyses the conjugation of various acyl donors and acceptors, resulting in the formation of rosmarinic acid and its precursor compounds. SpCYP98A75, SpCYP98A77 and SpCYP98A78 catalyse the formation of rosmarinic acid from its precursors at either the C‐3 or the C‐3′ position. Notably, SpCYP98A75 exhibited a stronger hydroxylation capacity at the C‐3′ position, whereas SpCYP98A77 and SpCYP98A78 demonstrate greater hydroxylation efficiency at the C‐3 position. Furthermore, SpCYP98A75 hydroxylated both the C‐3 and C‐3′ positions simultaneously, promoting the conversion of 4‐coumaroyl‐4′‐hydroxyphenyllactic acid to rosmarinic acid. Next, using a hairy root genetic transformation system for S. plebeia, we identified a basic helix–loop–helix protein type transcription factor, SpbHLH54, which positively regulates the biosynthesis of rosmarinic acid and homoplantaginin in S. plebeia. These findings provide a valuable genomic resource for elucidating the mechanisms of rosmarinic acid biosynthesis and its regulation and improve the understanding of evolutionary patterns within the Lamiaceae family.
Salicylic Acid, Hypersensitive Response and RBOHD‐Mediated Hydrogen Peroxide Accumulation Play Key Roles in Black Rot Resistance of Crucifers
Authors: Lin Chia‐Hua , Lee Bo‐Yi , Ou Yun‐Ting , Chiang Min‐Jui , Chen Chao‐Ying 
Published: February 2025

ABSTRACTBlack rot caused by hemibiotrophic Xanthomonas campestris pv. campestris (Xcc) is a great problem in crucifer crop production. Various host responses are activated upon Xcc attack; however, their roles in black rot resistance remain ambiguous. In this study, a highly black rot resistance of host plants was achieved by applying a field‐screened systemic resistance‐eliciting Bacillus velezensis strain 37‐1. The contributions of strain 37‐1‐altered host responses to Xcc resistance were then investigated in Arabidopsis. Hypersensitive response and hydrogen peroxide accumulation were demonstrated beneficial for Xcc infection by using nrg1 and rbohd mutants, histochemical staining against host cell death and reactive oxygen species, detection of antioxidant enzyme activity and RT‐qPCR assay. By contrast, salicylic acid was proven essential for black rot suppression by using NahG transformant, mutants impaired in defence hormone synthesis and signalling pathway, and RT‐qPCR assay. Additionally, both isochorismate synthase and phenylalanine ammonia‐lyase pathways for salicylic acid biosynthesis were found to be involved in resistance to Xcc. These findings improve the knowledge of host defence responses crucial for fighting off hemibiotrophic Xcc.
The Effectiveness of Physical Activity and Nutrition Interventions for Children and Adolescents With Cerebral Palsy to Improve Physical Health and Cognitive Outcomes: A Systematic Review
Authors: Cossington Jo , Coe Shelly , Nagy Liana , Mitaras Thomas , Dawes Helen 
Published: February 2025

Purpose: Using systematic review methodology, we set out to describe the evidence for physical activity and nutrition interventions for children and adolescents with cerebral palsy (CP) as compared with no intervention or exposure that reports physical health and cognitive outcomes. Method: Quantitative, primary studies that explored the effectiveness of these interventions, replicable in school and home contexts, in comparison to any other or no intervention or exposure in children and adolescents between the ages of 6–18 years old with a diagnosis of cerebral palsy were included (PROSPERO CRD42022322143). Risk of bias was assessed by Joanna Briggs Institute and QualSyst. Results: A total of 16 international heterogeneous studies (13 physical activity and 3 nutrition) with interventions ranging from a single exposure to 8 months, with quality 58% to 89% and effectiveness, D = 0.03 to 0.97, were included. Outcome measures were varied. Conclusion: The review brings together a number of high-quality studies on physical activity and nutrition interventions and promising findings of impact on cardiovascular, musculoskeletal, and cognitive outcomes. Evidence supports implementation of these interventions in community contexts. Future research would benefit from agreement on the use of core outcome measures for meta-synthesis.