bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gravity-matter sum rules in models with a single extra-dimension
Authors: de Giorgi A. , Vogl S. 
Published: May 2024

Abstract
We prove a set of sum rules needed for KK-graviton pair production from matter in orbifolded extra-dimensional models. The sum rules can be found in full generality by considering the properties of solutions to the Sturm-Liouville problem, which describes the wave functions and the masses of the KK-gravitons in four dimensions. They ensure cancellations in the amplitudes of the processes mentioned above which considerably reduce their growth with s in the high-energy limit. This protects extra-dimensional theories from the low-scale unitarity problems that plague other theories with massive spin-2 particles. We argue that such relations are valid for a broader category of models thus generalizing our previous results that were limited to the large μ limit of the Randall-Sundrum model.
Streaming approximation resistance of every ordering CSP
Authors: Singer Noah G. , Sudan Madhu , Velusamy Santhoshini 
Published: May 2024

AbstractAn ordering constraint satisfaction problem (OCSP) is defined by a family$$\mathcal F$$Fof predicates mapping permutations on$$\{1,\ldots,k\}$${1,…,k}to$$\{0,1\}$${0,1}. An instance of ($$\mathcal F$$F) onnvariables consists of a list of constraints, each consisting of a predicate from$$\mathcal F$$Fapplied onkdistinct variables. The goal is to find an ordering of thenvariables that maximizes the number of constraints for which the induced ordering on thekvariables satisfies the predicate. OCSPs capture well-studied problems including ‘maximum acyclic subgraph’ () and “maximum betweenness”. In this work, we consider the task of approximating the maximum number of satisfiable constraints in the (single-pass) streaming setting, when an instance is presented as a stream of constraints. We show that for every$$\mathcal F$$F, ($$\mathcal F$$F) is approximation-resistant to o(n)-space streaming algorithms, i.e., algorithms using o(n) space cannot distinguish streams where almost every constraint is satisfiable from streams where no ordering beats the random ordering by a noticeable amount. This space bound is tight up to polylogarithmic factors. In the case of , our result shows that for every$$\epsilon>0$$ϵ>0, is not$$(1/2+\epsilon)$$(1/2+ϵ)-approximable in o(n) space. The previous best inapproximability result, due to Guruswami & Tao (2019), only ruled out 3/4-approximations in$$o(\sqrt n)$$o(n)space. Our results build on recent works of Chou et al. (2022b, 2024) who provide a tight, linear-space inapproximability theorem for a broad class of “standard” (i.e., non-ordering) constraint satisfaction problems (CSPs) over arbitrary (finite) alphabets. Our results are obtained by building a family of appropriate standard CSPs (one for every alphabet sizeq) from any given OCSP and applying their theorem to this family of CSPs. To convert the resulting hardness results for standard CSPs back to our OCSP, we show that the hard instances from this earlier theorem have the following “partition expansion” property with high probability: For every partition of thenvariables into small blocks, for most of the constraints, all variables are in distinct blocks.
Precision in Practice: The Critical Role of Mesh and Procedure Type Specification in Urogynecological Surgeries and Research
Authors: Rotem Reut , Galvin Daniel , Daykan Yair , Al-shukaili Sumaiya , O’Reilly Barry A. , O’Sullivan Orfhlaith E. 
Published: May 2024

AbstractRecently, the debate surrounding the use of mesh in urogynecological procedures has intensified, leading to FDA warnings and heightened safety concerns. This clinical opinion emphasizes the vital need to specify mesh types in these procedures, drawing attention to the risk profiles and clinical outcomes associated with various meshes and the procedures that utilize them. A significant issue identified in contemporary literature is the tendency to group diverse mesh types under the same umbrella, disregarding their unique characteristics and applications. We describe the range of mesh types, their application routes, and associated complications, highlighting the risks of this nonspecific approach to patient safety and informed decision making. We critically examine the generalization of mesh terminology in clinical and research dialogues. Concluding with specific recommendations for health care providers and researchers, the paper advocates for a more nuanced understanding and communication in the field, ultimately aiming to improve patient care and safety in urogynecological practice.
Preventive Effects of Dental Pulp Stem Cell-conditioned Media on Anti-RANKL Antibody-Related Osteonecrosis of the Jaw
Authors: Kaminogo Kento , Yamaguchi Satoshi , Chen Hui , Yagita Hideo , Toyama Naoto , Urata Yusuke , Hibi Hideharu 
Published: May 2024

AbstractMedication-related osteonecrosis of the jaw is a serious disease occurring in patients with cancer and osteoporosis, who are undergoing treatment with antiresorptive agents (ARAs) such as bisphosphonate (BP) or denosumab, an antibody targeting receptor activator of NF-κB ligand. Recently, stem cell-based therapy has been shown to be effective in preventing the development of bisphosphonate-related osteonecrosis of the jaw. However, studies on denosumab-related osteonecrosis of the jaw (DRONJ) remain limited. Here, the efficacy of treatment with dental pulp stem cell conditioned media (DPSC-CM) in preventing DRONJ in a murine model was evaluated. Local administration of DPSC-CM into the extraction socket of a mouse with DRONJ decreased the number of empty osteocyte lacunae and the prevalence of ONJ. In tissues surrounding the extraction sockets in the DPSC-CM-treated group, the expression of inflammatory cytokines was attenuated and that of osteogenesis-related molecules was enhanced compared to that in the control group. Further, the expression of Wnt signaling molecules, which had been suppressed, was improved. These findings collectively suggest that DPSC-CM prevents ONJ development in a murine DRONJ model.
Epitope mapping and establishment of a blocking ELISA for mAb targeting the p72 protein of African swine fever virus
Authors: Liao Huan-Cheng , Shi Zheng-Wang , Zhou Gai-Jing , Luo Jun-Cong , Wang Wan-Ying , Feng Lu , Zhang Fan , Shi Xin-Tai , Tian Hong , Zheng Hai-Xue 
Published: May 2024

Abstract
The African swine fever virus (ASFV) has the ability to infect pigs and cause a highly contagious acute fever that can result in a mortality rate as high as 100%. Due to the viral epidemic, the pig industry worldwide has suffered significant financial setbacks. The absence of a proven vaccine for ASFV necessitates the development of a sensitive and reliable serological diagnostic method, enabling laboratories to effectively and expeditiously detect ASFV infection. In this study, four strains of monoclonal antibodies (mAbs) against p72, namely, 5A1, 4C4, 8A9, and 5E10, were generated through recombinant expression of p72, the main capsid protein of ASFV, and immunized mice with it. Epitope localization was performed by truncated overlapping polypeptides. The results indicate that 5A1 and 4C4 recognized the amino acid 20–39 aa, 8A9 and 5E10 are recognized at 263–282 aa, which is consistent with the reported 265–280 aa epitopes. Conserved analysis revealed 20–39 aa is a high conservation of the epitopes in the ASFV genotypes. Moreover, a blocking ELISA assay for detection ASFV antibody based on 4C4 monoclonal antibody was developed and assessed. The receiver-operating characteristic (ROC) was performed to identify the best threshold value using 87 negative and 67 positive samples. The established test exhibited an area under the curve (AUC) of 0.9997, with a 95% confidence interval ranging from 99.87 to 100%. Furthermore, the test achieved a diagnostic sensitivity of 100% (with a 95% confidence interval of 95.72 to 100%) and a specificity of 98.51% (with a 95% confidence interval of 92.02 to 99.92%) when the threshold was set at 41.97%. The inter- and intra-batch coefficient of variation were below 10%, demonstrating the exceptional repeatability of the method. This method can detect the positive standard serum at a dilution as high as 1:512. Subsequently, an exceptional blocking ELISA assay was established with high diagnostic sensitivity and specificity, providing a novel tool for detecting ASFV antibodies.

Key points
• Four strains of ASFV monoclonal antibodies against p72 were prepared and their epitopes were identified.
• Blocking ELISA method was established based on monoclonal antibody 4C4 with an identified conservative epitope.
• The established blocking ELISA method has a good effect on the detection of ASFV antibody.
Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: a systematic review and meta-analysis
Authors: O’Sullivan Niall J. , Temperley Hugo C. , Kyle Eimear T. , Sweeney Kevin J. , O’Neill Maeve , Gilham Charles , O’Sullivan Jacintha , O’Kane Grainne , Mehigan Brian , O’Toole Sharon , Larkin John , Gallagher David , McCormick Paul , Kelly Michael E. 
Published: May 2024

Abstract
Introduction
Circulating tumour DNA (ctDNA) has emerged as a promising biomarker in various cancer types, including locally advanced rectal cancer (LARC), offering potential insights into disease progression, treatment response and recurrence. This review aims to comprehensively evaluate the utility of ctDNA as a prognostic biomarker in LARC.

Methods
PubMed, EMBASE and Web of Science were searched as part of our review. Studies investigating the utility of ctDNA in locally advanced rectal cancer (LARC) were assessed for eligibility. Quality assessment of included studies was performed using the Newcastle Ottawa Scale (NOS) risk of bias tool. Outcomes extracted included basic participant characteristics, ctDNA details and survival data. A meta-analysis was performed on eligible studies to determine pooled recurrence-free survival (RFS).

Results
Twenty-two studies involving 1676 participants were included in our analysis. Methodological quality categorised by the Newcastle Ottawa Scale was generally satisfactory across included studies. ctDNA detected at various time intervals was generally associated with poor outcomes across included studies. Meta-analysis demonstrated a pooled hazard ratio of 8.87 (95% CI 4.91–16.03) and 15.15 (95% CI 8.21–27.95), indicating an increased risk of recurrence with ctDNA positivity in the post-neoadjuvant and post-operative periods respectively.

Conclusion
Our systematic review provides evidence supporting the prognostic utility of ctDNA in patients with LARC, particularly in identifying patients at higher risk of disease recurrence in the post-neoadjuvant and post-operative periods.
Vitamin C deficiency after kidney transplantation: a cohort and cross-sectional study of the TransplantLines biobank
Authors: Yepes-Calderón Manuela , van der Veen Yvonne , Martín del Campo S Fernando , Kremer Daan , Sotomayor Camilo G. , Knobbe Tim J. , Vos Michel J. , Corpeleijn Eva , de Borst Martin H. , Bakker Stephan J. L. ,   TransplantLines Investigators
Published: May 2024

Abstract
Purpose
Vitamin C deficiency is associated with excess mortality in kidney transplant recipients (KTR). We aim to evaluate plasma vitamin C status at different post-transplantation moments and assess the main characteristics associated with vitamin C deficiency in KTR.

Methods
Plasma vitamin C was assessed in 598 KTR at 3-, 6-, 12-, 24-, and 60-months post-transplantation, 374 late KTR with a functioning graft ≥ 1 year, and 395 potential donors. Vitamin C deficiency was defined as plasma vitamin C ≤ 28 µmol/L. Diet was assessed by a 177-item food frequency questionnaire. Data on vitamin C-containing supplements use were extracted from patient records and verified with the patients.

Results
Vitamin C deficiency ranged from 46% (6-months post-transplantation) to 30% (≥ 1 year post-transplantation). At all time points, KTR had lower plasma vitamin C than potential donors (30–41 µmol/L vs 58 µmol/L). In cross-sectional analyses of the 953 KTR at their first visit ≥ 12 months after transplantation (55 ± 14 years, 62% male, eGFR 55 ± 19 mL/min/1.73 m2), the characteristics with the strongest association with vitamin C deficiency were diabetes and smoking (OR 2.67 [95% CI 1.84–3.87] and OR 1.84 [95% CI 1.16–2.91], respectively). Dietary vitamin C intake and vitamin C supplementation were associated with lower odds (OR per 100 mg/day 0.38, 95% CI 0.24–0.61 and OR 0.21, 95% CI 0.09–0.44, respectively).

Conclusion
Vitamin C deficiency is frequent among KTR regardless of the time after transplantation, especially among those with diabetes and active smokers. The prevalence of vitamin C deficiency was lower among KTR with higher vitamin C intake, both dietary and supplemented. Further research is warranted to assess whether correcting this modifiable risk factor could improve survival in KTR.
Association between the consumption of ultra-processed foods and the incidence of peptic ulcer disease in the SUN project: a Spanish prospective cohort study
Authors: Leone Alessandro , De la Fuente-Arrillaga Carmen , Mas Mariano Valdés , Sayon-Orea Carmen , Menichetti Francesca , Martínez-Gonzalez Miguel Angel , Bes-Rastrollo Maira 
Published: May 2024

Abstract
Purpose
Consumption of ultra-processed foods (UPF) has increased despite potential adverse health effects. Recent studies showed an association between UPF consumption and some gastrointestinal disorders. We evaluated the association between UPF consumption and peptic ulcer disease (PUD) in a large Spanish cohort.

Methods
We conducted a prospective analysis of 18,066 participants in the SUN cohort, followed every two years. UPF was assessed at baseline and 10 years after. Cases of PUD were identified among participants reporting a physician-made diagnosis of PUD during follow-ups. Cases were only partially validated against medical records. Cox regression was used to assess the association between baseline UPF consumption and PUD risk. Based on previous findings and biological plausibility, socio-demographic and lifestyle variables, BMI, energy intake, Helicobacter pylori infection, gastrointestinal disorders, aspirin and analgesic use, and alcohol and coffee consumption were included as confounders.We fitted GEE with repeated dietary measurements at baseline and after 10 years of follow-up. Vanderweele’s proposed E value was calculated to assess the sensitivity of observed associations to uncontrolled confounding.

Results
During a median follow-up of 12.2 years, we recorded 322 new PUD cases (1.56 cases/1000 person-years). Participants in the highest baseline tertile of UPF consumption had an increased PUD risk compared to participants in the lowest tertile (HR = 1.52, 95% CI: 1.15, 2.00, Ptrend=0.002). The E-values for the point estimate supported the observed association. The OR using repeated measurements of UPF intake was 1.39 (95% CI: 1.03, 1.87) when comparing extreme tertiles.

Conclusion
The consumption of UPF is associated with an increased PUD risk.
Influence of nitrate supplementation on motor unit activity during recovery following a sustained ischemic contraction in recreationally active young males
Authors: Esen Ozcan , Bailey Stephen J. , Stashuk Daniel W. , Howatson Glyn , Goodall Stuart 
Published: May 2024

Abstract
Purpose
Dietary nitrate (NO3−) supplementation enhances muscle blood flow and metabolic efficiency in hypoxia, however, its efficacy on neuromuscular function and specifically, the effect on motor unit (MU) activity is less clear. We investigated whether NO3− supplementation affected MU activity following a 3 min sustained ischemic contraction and whether this is influenced by blood flow restriction (BFR) during the recovery period.

Method
In a randomized, double-blinded, cross-over design, 14 males (mean ± SD, 25 ± 6 years) completed two trials following 5 days of supplementation with NO3−-rich (NIT) or NO3−-depleted (PLA) beetroot juice to modify plasma nitrite (NO2−) concentration (482 ± 92 vs. 198 ± 48 nmol·L−1, p < 0.001). Intramuscular electromyography was used to assess MU potential (MUP) size (duration and area) and mean firing rates (MUFR) during a 3 min submaximal (25% MVC) isometric contraction with BFR. These variables were also assessed during a 90 s recovery period with the first half completed with, and the second half completed without, BFR.

Results
The change in MUP area and MUFR, did not differ between conditions (all p > 0.05), but NIT elicited a reduction in MUP recovery time during brief isometric contractions (p < 0.001), and during recoveries with (p = 0.002) and without (p = 0.012) BFR.

Conclusion
These novel observations improve understanding of the effects of NO3− on the recovery of neuromuscular function post-exercise and might have implications for recovery of muscle contractile function.

Trial registration
The study was registered on clinicaltrials.gov with ID of NCT05993715 on August 08, 2023.
The practice of principles: Planck’s vision of a relativistic general dynamics
Authors: Giovanelli Marco 
Published: May 2024

AbstractPlanck’s pioneering contributions to special relativity have received less consideration than one might expect in the historiography and philosophy of physics. Although they are celebrated in isolation, they are mostly not understood as integral to an overarching project. This paper aims (a) to provide a historically accurate overview of Planck’s contributions to the early history of relativity that is reasonably accessible to today’s reader, (b) to demonstrate how these contributions can be presented against the background of Planck’s ‘Helmholtzian’ vision of relativistic general dynamics based on the principle of relativity and principle of least action, and (c) to argue that Planck’s general dynamics serves as an illuminating example of the use of ‘principles’ in physics.
Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review
Authors: Cucinotta Francescopaolo , Swinnen Bart , Makovac Elena , Hirschbichler Stephanie , Pereira Erlick , Little Simon , Morgante Francesca , Ricciardi Lucia 
Published: May 2024

Abstract
Background
Autonomic dysfunction is common and disabling in Parkinson's disease (PD). The effects of deep brain stimulation (DBS) on the cardiovascular system in PD remain poorly understood. We aimed to assess the effect of DBS on cardiovascular symptoms and objective measures in PD patients.

Methods
We conducted a systematic literature search in PubMed/MEDLINE.

Results
36 out of 472 studies were included, mostly involving DBS of the subthalamic nucleus, and to a lesser extent the globus pallidus pars interna and pedunculopontine nucleus. Seventeen studies evaluated the effect of DBS on patient-reported or clinician-rated cardiovascular symptoms, showing an improvement in the first year after surgery but not with longer-term follow-up. DBS has no clear direct effects on blood pressure during an orthostatic challenge (n = 10 studies). DBS has inconsistent effects on heart rate variability (n = 10 studies).

Conclusion
Current evidence on the impact of DBS on cardiovascular functions in PD is inconclusive. DBS may offer short-term improvement of cardiovascular symptoms in PD, particularly orthostatic hypotension, which may be attributed to dopaminergic medication reduction after surgery. There is insufficient evidence to draw conclusions on the direct effect of DBS on blood pressure and heart rate variability.
Side differences and reproducibility of the Moxy muscle oximeter during cycling in trained men
Authors: Skotzke Philip , Schwindling Sascha , Meyer Tim 
Published: May 2024

Abstract
Purpose
Portable near-infrared spectroscopy devices allow measurements of muscle oxygen saturation (SmO2) in real time and non-invasively. To use NIRS for typical applications including intensity control and load monitoring, the day-to-day variability needs to be known to interpret changes confidently. This study investigates the absolute and relative test–retest reliability of the Moxy Monitor and investigates side differences of SmO2 at the vastus lateralis muscle of both legs in cyclists.

Methods
Twelve trained cyclists and triathletes completed 3 incremental step tests with 5 min step duration starting at 1.0 W/kg with an increase of 0.5 W/kg separated by 2–7 days. SmO2 was averaged over the last minute of each stage. For all power outputs, the intra-class coefficient (ICC), the standard error of measurement (SEM) and the minimal detectable change (MDC) were calculated. Dominant and non-dominant leg SmO2 were compared using a three-factor ANOVA and limits of agreement (LoA).

Results
ANOVA showed no significant systematic differences between trials and side. For both legs and all intensities, the ICC ranged from 0.79 to 0.92, the SEM from 5 to 9% SmO2 and the MDC from 14 to 18% SmO2. The bias and LoA between both legs were −2.0% ± 19.9% SmO2.

Conclusion
Relative reliability of SmO2 was numerically good to excellent according to current standards. However, it depends on the specific analytical goal whether the test–retest reliability is deemed sufficient. Wide LoA indicate side differences in muscle oxygenation during exercise unexplained by leg dominance.
Fluid and electrolyte balance following consumption of skimmed milk and a plant-based soya beverage at rest in euhydrated males
Authors: Peden Donald L. , Derbyshire Seamus , Funnell Mark P. , McLeod Chris J. , Rumbold Penny , Hansell Emily , Clifford Tom , Mears Stephen A. , James Lewis J. 
Published: May 2024

Abstract
Purpose
Cow’s milk is one of the most hydrating beverages, but many individuals choose not to consume dairy in their diet due to intolerance, allergy, or dietary preference. Milk is commonly replaced with plant-based beverages, including soya which has the most comparable protein content, but little is known about their hydration potential. This study compared fluid and electrolyte balance responses between a soya beverage and skimmed cow’s milk.

Methods
Ten healthy males [age 27 (6) y; body mass index 24.6 (2.3) kg/m2] completed two randomised counterbalanced trials, involving consuming 1000 mL water from approximately isocaloric amounts of skimmed cow’s milk (MILK) or a sweetened soya beverage (SOYA), in four aliquots over 30 min in a euhydrated fasted state. Volume, specific gravity, and electrolyte (sodium, potassium, chloride) concentrations were determined in total-void urine samples collected pre-/post-beverage ingestion, and hourly for 180 min thereafter. Hunger, thirst, nausea and stomach fullness were rated proximal to urine samples.

Results
Total urine mass (MILK, 986 ± 254 g; SOYA, 950 ± 248 g; P = 0.435) and urine specific gravity (P = 0.156) did not differ between trials. Potassium balance was greater in SOYA 0–180 min post-beverage (P ≤ 0.013), whilst chloride balance was greater in MILK 0–120 min post-beverage (P ≤ 0.036). Sodium balance (P = 0.258), total electrolyte balance (P = 0.258), and subjective measures (P ≥ 0.139) were not different between trials.

Conclusion
Replacing cow’s milk with a soya beverage did not negatively impact fluid balance in healthy young males, making it a viable option for those who choose not to consume dairy in their diet.