bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrospinning of fluorescent fibers from CdSe/ZnS quantum dots in cellulose triacetate
Authors: Abitbol Tiffany , Wilson Jordan T. , Gray Derek G. 
Published: July 2010

AbstractFluorescent cellulose triacetate (CTA) fibers were prepared by electrospinning solutions of CTA dissolved in an 8 : 2 v/v cosolvent system of methylene chloride (MC) and methanol (MeOH) which contained CdSe/ZnS quantum dots (QDs). The relatively low loading of colloidal nanoparticles was sufficient to impart fluorescence to the fibers but did not significantly alter fiber morphologies, which tended toward smooth surfaces with the occasional longitudinal feature. The fibers were birefringent due to the alignment of the polymer chains which occurred during electrospinning and had widths on the order of a hundred nanometers. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Electrical properties of poly(p‐phenylene vinylene) films with an incorporation of platinum metal nanoparticles
Authors: Lee Cho‐Young , Choi Yong‐June , Park Hyung‐Ho 
Published: July 2010

AbstractThe effects of platinum metal nanoparticles on a conjugated polymer were investigated by monitoring the electronic structures and measuring the electrical properties of poly(p‐phenylene vinylene) (PPV) and PPV/Pt nanocomposites films. Enhanced current density in PPV/Pt nanocomposite films was obtained by the incorporation of Pt nanoparticles into the conjugated polymer PPV. This result agrees well with our observation of an increase in the electron affinity and an increase in roughness with increasing Pt nanoparticle content. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Sepiolite‐reinforced epoxy nanocomposites: Thermal, mechanical, and morphological behavior
Authors: Nohales Andrés , Muñoz‐Espí Rafael , Félix Paula , Gómez Clara M. 
Published: July 2010

AbstractA bisphenol A‐based epoxy resin was modified with pristine sepiolite and an organically surface‐modified sepiolite and thermally cured using two different curing agents: an aliphatic and a cycloaromatic diamine. The nanocomposites were characterized by dynamic mechanical analysis (DMA), rheology, thermogravimetric analysis (TGA), and electron microscopy. The initial sepiolite–epoxy mixtures show a better dispersion for the sepiolite‐modified system that forms a percolation network structure. Mechanical properties have also been determined. The flexural modulus of the epoxy matrix slightly increases by the incorporation of the organophilic sepiolite. The flexural strength of the sepiolite‐modified resin cured with the aliphatic diamine increased by 10%, while the sepiolite‐modified resin cured with the cycloaromatic diamine resulted in a lower flexural strength, as compared with the unmodified resin. Electron micrographs revealed a better nanodispersion of the sepiolite in the epoxy matrix for the organophilic modified sepiolite nanocomposite. The initial thermal decomposition temperature did not change significantly with the addition of sepiolite, whereas mechanical properties were affected. The reduced flexural strength was attributed to the stress concentrations caused by the sepiolite modifier. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Homoleptic Platinum(II) and Palladium(II) Organothiolates and Phenylselenolates: Solvothermal Synthesis, Structural Determination, Optical Properties, and Single‐Source Precursors for PdSe and PdS Nanocrystals
Authors: Chui Stephen Sin‐Yin , Low Kam‐Hung , Lu Jun , Roy V. A. L. , Chan Sharon Lai‐Fung , Che Chi‐Ming 
Published: July 2010

AbstractHomoleptic d8‐metal organothiolates and phenylselenolates [M(EC6H5)2]∞ (E=S, M=Pt 1, M=Pd 2, M=Ni 5; E=Se, M=Pt 3, M=Pd 4) were prepared as crystalline solids under solvothermal conditions. Their structures were solved using powder X‐ray diffraction data. In each case, the EC6H5 (E=S, Se) ligand binds to two metal ions (M=Pt, Pd, and Ni) to form chain‐like structures with planar (in 1) or zig‐zag (in 2, 3, 4, 5) conformations. The [M(SR)2]∞ complexes (M=Pt, R=4‐tert‐butylphenyl 6; R=2‐naphthyl 8; R=4‐nitrophenyl 10 and M=Pd, R=4‐tert‐butylphenyl 7; R=2‐naphthyl 9; R=4‐nitrophenyl 11) were prepared under similar solvothermal conditions. Based on the XPS binding energies and elemental analyses, complexes 6, 7, 8, 9, 10, 11 have the same [M(SR)2]∞ formulation as 1 and 2. The cyclic complex [Pd6(SCH3)12] 12 was prepared as a crystalline solid by solvothermal annealing treatment of the amorphous precipitate. A chain‐like polymer structure is proposed for both [Pd(SC12H25)2]∞ 13 and [Pd(SC16H33)2]∞ 14; these polymeric chains self‐assemble to give layer‐like structures. Solid‐state diffuse reflectance spectra reveal that the optical band gap Eg (eV) of complexes 1, 6, 8, 10 and of 2, 7, 9, 11 are in the range of 2.10–3.00 eV and 2.10–2.63 eV, respectively, and 5 has the lowest Eg value (1.72 eV). Heating solid samples of 4 and 13 under solvothermal conditions afforded phase‐pure Pd17Se15 and PdS nanocrystals, respectively. Field‐effect transistors fabricated with a drop‐cast thin film made from Pd17Se15 nanocrystals prior treated with an ethanolic solution of 1‐hexadecanethiol displayed ambipolar charge transporting properties with hole and electron mobility being 7×10−2 cm2 V−1 s−1 and 6×10−2 cm2 V−1 s−1, respectively.
Structural analysis of some soluble elastins by means of FT‐IR and 2D IR correlation spectroscopy
Authors: Popescu Maria‐Cristina , Vasile Cornelia , Craciunescu Oana 
Published: July 2010

AbstractFourier transform infrared (FT‐IR) spectroscopy combined with 2D correlation spectroscopy has been used to offer some information about stability and structure of some soluble elastins. Temperature has been chosen as the perturbation to monitor the infrared behavior of various soluble elastins, namely, α‐elastin p, α‐elastin, and k‐elastin. In the 3800–2700 cm−1 region, the H‐containing groups were analyzed. The bonded hydroxyls are found to decrease prior to the NH‐related hydrogen bonds and also to the conformational reorganization of hydrocarbon chains. The transition temperatures were evaluated and they were found to agree with those obtained from DSC data. The FTIR spectra and their 2nd derivatives denote that α‐ elastins exhibited amide‐I, ‐II and ‐III bands at 1656, 1539 and 1236 cm−1, respectively, while in k‐elastin these bands were found at 1652 cm−1 for amide I, 1540 cm−1 for amide II and 1248 cm−1 for amide III. The macroscopic IR finger‐print method, which combines: general IR spectra, secondary derivative spectra, and 2D‐IR correlation spectra, is useful to discriminate different elastins. Thus using the differences of the position and intensity of the bands from “fingerprint region” of studied elastins, which include the peaks assigned to CO, CC groups from α‐helix, β‐turn, and the peaks assigned to the amide groups, it is possible to identify and discriminate elastins from each others. Furthermore, the pattern of 2D‐IR correlation spectra under thermal perturbation, allow their direct identification and discrimination. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 1072–1084, 2010.This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Cellular Internalization of Water‐Soluble Helical Aromatic Amide Foldamers
Authors: Iriondo‐Alberdi Jone , Laxmi‐Reddy Katta , Bouguerne Benaissa , Staedel Cathy , Huc Ivan 
Published: July 2010

AbstractThe intracellular transport of drugs and therapeutics represents one of the most exciting and challenging areas at the interface of chemistry, biology, and medicine. Most of the effort in this field so far has been devoted to the development of peptide‐based delivery systems that can translocate therapeutic agents into their intracellular targets. More recently, the use of bioinspired non‐natural foldamers has resulted in the successful delivery of cargo molecules, which possess a wide range of sizes and physicochemical properties across the cell membrane. We report herein the synthesis of aromatic amide foldamers and their biological evaluation as cell‐penetrating agents. By using a well‐established synthetic route, a series of fluorescein‐labeled cationic aryl amide conjugates has been constructed, and their cellular uptake into various human cell lines has been analyzed by flow cytometry and fluorescence microscopy. The assays revealed that longer oligomers achieve greater cellular translocation, with octamer Q8 proving to be a remarkable vehicle for all three cell lines. Biological studies have also indicated that these helices are biocompatible, thus showing promise in their application as cell‐penetrating agents and as vehicles to deliver biologically active molecules into cells.
Generalized Spitzer Function with Finite Collisionality in Toroidal Plasmas
Authors: Kernbichler W. , Kasiov S. V. , Leitold G. O. , Nemov V. V. , Marushchenko N. B. 
Published: July 2010

AbstractThe drift kinetic equation solver NEO‐2 [1] which is based on the field line integration technique has been applied to compute the generalized Spitzer function in a tokamak with finite plasma collisionality. The resulting generalized Spitzer function has specific features which are pertinent to the finite plasma collisionality. They are absent in asymptotic (collisionless or highly collisional) regimes or in results drawn from interpolation between asymptotic limits. These features have the potential to improve the overall ECCD efficiency if one optimizes the microwave beam launch scenarii accordingly (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Gyrokinetic Theory of Rotation in Stellarators
Authors: Helander P. , Simakov A. N. 
Published: July 2010

AbstractIt is shown that gyrokinetic turbulence is in general unable to significantly affect the large‐scale radial electric field and rotation of a stellarator plasma. This rotation is thus close to that calculated by neoclassical theory without fluctuations. Only if the magnetic configuration is very close to being perfectly quasiaxisymmetric or quasihelically symmetric can the bulk plasma rotation be affected by gyrokinetic turbulence. This conclusion follows from the orderings underlying the derivation of the gyrokinetic equation, and does therefore not require this equation actually to be solved. On the other hand, on small scales with a radial extent comparable to the ion gyroradius, zonal flows may be excited by gyrokinetic turbulence and could modify the ensuing transport (© 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Appl1 is dispensable for Akt signaling in vivo and mouse T‐cell development
Authors: Tan Yinfei , You Huihong , Coffey Francis J. , Wiest David L. , Testa Joseph R. 
Published: July 2010

AbstractAppl1 (Adaptor protein containing pleckstrin homology [PH], phosphotyrosine binding [PTB], and Leucine zipper motifs) is an adaptor that participates in cell signaling by interacting with various signaling molecules including Akt, PI3‐kinase (PI3K), Rab5, adiponectin receptor, and TrkA. By using RNA knockdown technology, Appl1 has been implicated in zebrafish development and murine glucose metabolism. To investigate the unambiguous role of Appl1 in vivo, we generated a knockout mouse in which exon1 of the Appl1 gene was disrupted using gene trap methodology. Homozygous Appl1 knockout mice with ubiquitous loss of Appl1 protein expression were viable, grossly normal, and born at expected Mendelian ratios. Moreover, activation of Akt and the downstream effecter Gsk3β was unaffected in vivo. We next performed glucose and insulin tolerance tests and found that glucose metabolism is normal in Appl1‐null mice. We also tested the effect of Appl1 loss on Akt signaling in T cells, because we discovered that Appl1 strongly interacts with the p110β subunit of PI3K in T lymphocytes. However, such interaction was found to be dispensable for Akt signaling in thymic T cells and T‐cell development. Moreover, Appl1 loss did not affect DNA synthesis in cultured thymocytes, although loss of Appl1 was associated with a slight increase in ConA‐stimulated splenic T‐cell viability/proliferation. Collectively, our findings indicate that Appl1 is dispensable for Akt signaling in vivo and T‐cell differentiation. genesis 48:531–539, 2010. © 2010 Wiley‐Liss, Inc.
ROSA26Flpo deleter mice promote efficient inversion of conditional gene traps in vivo
Authors: Raymond Christopher S. , Soriano Philippe 
Published: July 2010

AbstractGene trap mutagenesis in embryonic stem cells is an important tool to help elucidate gene function in current mouse mutagenesis efforts. Vector systems based on inversion of the gene trap module have recently been devised to allow for conditional mutagenesis. However, additional efforts are needed to improve this technology including improving the efficiency of site‐specific recombinases required to manipulate these conditional vectors in vivo. Here we describe a mouse line carrying the codon‐optimized FLP recombinase Flpo at the ROSA26 locus that functions at higher efficiency than a similar Flpe line in mediating the DNA inversion of a conditional gene trap cassette in vivo. genesis 48:603–606, 2010. © 2010 Wiley‐Liss, Inc.
Comparative prevalence, correlates of impairment, and service utilization for eating disorders across US ethnic groups: Implications for reducing ethnic disparities in health care access for eating disorders
Authors: Marques Luana , Alegria Margarita , Becker Anne E. , Chen Chih‐nan , Fang Angela , Chosak Anne , Diniz Juliana Belo 
Published: July 2010

AbstractObjective:The study compared the prevalence, correlates of functional impairment, and service utilization for eating disorders across Latinos, Asians, and African Americans living in the United States to non‐Latino Whites.Method:Pooled data from the NIMH Collaborative Psychiatric Epidemiological Studies (CPES;NIMH, 2007) were used.Results:The prevalence of anorexia nervosa (AN) and binge‐eating disorder (BED) were similar across all groups examined, but bulimia nervosa (BN) was more prevalent among Latinos and African Americans than non‐Latino Whites. Despite similar prevalence of BED among ethnic groups examined, lifetime prevalence of any binge eating (ABE) was greater among each of the ethnic minority groups in comparison to non‐Latino Whites. Lifetime prevalence of mental health service utilization was lower among ethnic minority groups studied than for non‐Latino Whites for respondents with a lifetime history of any eating disorder.Discussion:These findings suggest the need for clinician training and health policy interventions to achieve optimal and equitable care for eating disorders across all ethnic groups in the United States. © 2010 by Wiley Periodicals, Inc. (Int J Eat Disord 2011)
miR‐29b and miR‐125a regulate podoplanin and suppress invasion in glioblastoma
Authors: Cortez Maria Angelica , Nicoloso Milena Sabrina , Shimizu Masayoshi , Rossi Simona , Gopisetty Gopal , Molina Jennifer R. , Carlotti Carlos , Tirapelli Daniela , Neder Luciano , Brassesco Maria Sol , Scrideli Carlos Alberto , Tone Luiz Gonzaga , Georgescu Maria‐Magdalena , Zhang Wei , Puduvalli Vinay , Calin George Adrian 
Published: July 2010

AbstractGlioblastoma is the most frequent and malignant brain tumor, characterized by an elevated capacity for cellular proliferation and invasion. Recently, it was demonstrated that podoplanin membrane sialo‐glycoprotein encoded by PDPN gene is over‐expressed and related to cellular invasion in astrocytic tumors; however the mechanisms of regulation are still unknown. MicroRNAs are noncoding RNAs that regulate gene expression and several biological processes and diseases, including cancer. Nevertheless, their roles in invasion, proliferation, and apoptosis of glioblastoma are not completely understood. In this study, we focused on miR‐29b and miR‐125a, which were predicted to regulate PDPN, and demonstrated that these microRNAs directly target the 3′ untranslated region of PDPN and inhibit invasion, apoptosis, and proliferation of glioblastomas. Furthermore, we report that miR‐29b and miR‐125a are downregulated in glioblastomas and also in CD133‐positive cells. Taken together, these results suggest that miR‐29b and miR‐125a represent potential therapeutic targets in glioblastoma. © 2010 Wiley‐Liss, Inc.
Paleoenvironmental reconstruction of Holocene coastal sediments adjacent to archaeological ruins in Aqaba, Jordan
Authors: Allison Alivia J. , Niemi Tina M. 
Published: July 2010

AbstractStratified cultural remains from the Early Roman/Nabataean to Byzantine periods in the coastal zone of Aqaba, Jordan, and analyses of thirteen sediment cores provide evidence for changes in the depositional environment during the Holocene. The overall trend in subsurface sediments is a basal marine transgressive layer overlain by a regressional sequence of embayment lagoonal sediments identified from microfossil analyses, and backshore pond, alluvium, and eolian deposits until the 1st century B.C., when mudbrick structures appear. Based on two radiocarbon dates, a brackish water coastal embayment formed prior to ca. 5900–5700 B.C. and was subsequently filled by siltation. Local tectonic subsidence along faults of the Dead Sea transform may have helped form the lagoon. Freshwater Candona sp. ostracods found in sand layers in the lagoon facies show signs of having been transported and redeposited. These data indicate that lakes or marshes were likely located inland of the study area. Supporting faunal and floral evidence for wetter climatic conditions, wetland habitats, and extensive water diversion and agricultural terraces has been excavated at late Chalcolithic (4000–3500 B.C.) sites in the Aqaba region (Khalil & Schmidt, 2009). By the 8th century B.C., the depositional environment along the coastal plain of Aqaba was dominated by distal alluvial fan and eolian sedimentation and the shoreline had prograded about 400m seaward. The migration of human settlements since the 8th century B.C. from the center of the valley toward the southeast may be driven by the changing course of Wadi Yutim and conditions along the coastal plain. © 2010 Wiley Periodicals, Inc.
Predicting postoperative morbidity and mortality by model for endstage liver disease score for patients with head and neck cancer and liver cirrhosis
Authors: Kao Huang‐Kai , Guo Li‐Fei , Cheng Ming‐Huei , Chen I‐How , Liao Chun‐Ta , Fang Ku‐Hao , Yu Jau‐Song , Chang Kai‐Ping 
Published: July 2010

AbstractBackgroundThe purpose of this study was to evaluate the Model for Endstage Liver Disease (MELD) scoring system for predicting the morbidity and mortality of patients with head and neck cancer with liver cirrhosis undergoing tumor resection with microsurgical free‐tissue transfer.MethodsBetween January 2000 and December 2008, 3108 cases were retrospectively reviewed.ResultsThere were 59 men and 2 women enrolled in this study. Preoperatively, 31 and 30 patients were classified as having lower (<9.73) and higher (>9.73) MELD scores, respectively. Patients with higher MELD scores had significantly more postoperative medical morbidities including pulmonary complications and gastrointestinal bleeding. The mortality rate was also significantly higher for higher MELD scorers (23.3% vs 3.2%; p = 0.026). By logistic regression model, preoperative MELD score was a significant predictive factor for morbidity and mortality in multivariate analysis.ConclusionMELD score could be used to predict morbidity and mortality for patients with head and neck cancer with liver cirrhosis undergoing tumor resection with microsurgical free tissue transfer. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
The Ewing's sarcoma fusion protein, EWS‐FLI, binds Runx2 and blocks osteoblast differentiation
Authors: Li Xiaodong , McGee‐Lawrence Meghan E. , Decker Matthew , Westendorf Jennifer J. 
Published: July 2010

AbstractEwing's sarcomas are highly aggressive round cell tumors of bone and soft tissues that afflict children and young adults. The majority of these tumors harbor the t(11;22) translocation and express the fusion protein EWS‐FLI. Modern molecular profiling experiments indicate that Ewing's tumors originate from mesenchymal precursors in young individuals. EWS‐FLI alters the morphology of mesenchymal cells and prevents lineage specification; however, the molecular mechanisms for differentiation arrest are unclear. We recently showed that EWS‐FLI binds Runx2, a master regulator of osteoblast differentiation. In this report, we demonstrate that FLI sequences within EWS‐FLI are responsible for interactions with Runx2. EWS‐FLI blocks the expression of osteoblastic genes in a multipotent progenitor cell line that requires Runx2 to integrate bone morphogenic protein (Bmp)2 signaling while increasing proliferation and altering cell morphology. These results demonstrate that EWS‐FLI blocks the ability of Runx2 to induce osteoblast specification of a mesenchymal progenitor cell. Disrupting interactions between Runx2 and EWS‐FLI1 may promote differentiation of the tumor cell. J. Cell. Biochem. 111: 933–943, 2010. © 2010 Wiley‐Liss, Inc.
Regulation of intracellular decorin via proteasome degradation in rat mesangial cells
Authors: Wu Huijuan , Jiang Weina , Zhang Yan , liu Ye , Zhao Zhonghua , Guo Muyi , Ma Duan , Zhang Zhigang 
Published: July 2010

AbstractDecorin (DCN) is a member of small leucine‐rich proteoglycan family that neutralizes the bioactivity of transforming growth factor‐beta1 (TGF‐β1). It has been proven to be a promising anti‐fibrotic agent to treat glomerulonephritis. But the underlining mechanism for regulating and degrading intracellular DCN is still not fully understood. In this study, we investigated the roles of ubiquitination in the regulation of cytoplasmic DCN metabolism in rat mesangial cells (MC) by immunoprecipitation and Western blot. The results showed that a proportion of cytoplasmic DCN was ubiquitinated in normal MC and was enhanced in N‐glycosylation inhibitor (tunicamycin)‐treated MC. After being treated with the proteasome inhibitor MG132, ubiquitinated DCN accumulated and displayed a prolonged half‐life, accompanied by decreased TGF‐β1 expression and reduced collagen IV mRNA level in MC. This study demonstrated that the stability and function of cytoplasmic DCN can be regulated by ubiquitin‐proteasome system (UPS) in MC, which implies that regulating the ubiquitination and degradation of DCN might be a novel approach for modulating MC bioactivity. J. Cell. Biochem. 111: 1010–1019, 2010. © 2010 Wiley‐Liss, Inc.