bluuebunny/crossref_metadata_2025_split huggingface dataset:
Look Who’s (Not) Talking
Authors: Beverly Elizabeth A. , Ganda Om P. , Ritholz Marilyn D. , Lee Yishan , Brooks Kelly M. , Lewis-Schroeder Nina F. , Hirose Masakazu , Weinger Katie 
Published: May 2012

OBJECTIVE
Nearly one-half of diabetic patients have glycated hemoglobin A1c (HbA1c) levels above recommended targets. Effective physician–patient communication improves glycemia and diabetes self-care; however, communication gaps may exist that prevent patients from discussing self-care problems with treatment providers.

RESEARCH DESIGN AND METHODS
We assessed diabetic patients’ (n = 316, 85% white, 51% female, 71% type 2 diabetes, 59 ± 11 years old, 16 ± 3 years education, 19 ± 13 years diabetes duration, and HbA1c = 7.9 ± 1.4%) HbA1c, frequency of self-care, diabetes-related distress, depressive and anxiety symptoms, coping styles, diabetes quality of life, and self-care communication in the treatment relationship. Multivariate logistic regression models examined the main and interaction effects of health and psychosocial factors associated with patients’ reluctance to discuss self-care.

RESULTS
Patients reported positive relationships with their doctors and valued honest communication; however, 30% of patients were reluctant to discuss self-care. Reluctant patients reported less frequent self-care (P = 0.05), lower diabetes quality of life (P = 0.002), and more diabetes-related distress (P = 0.001), depressive symptoms (P &lt; 0.001), and anxiety symptoms (P = 0.001). Patients who reported elevated depressive symptoms, although not necessarily major depression, were more likely to be reluctant to discuss self-care (odds ratio [OR] 1.66 for 10-point change in t score; P &lt; 0.001), whereas patients who were older (OR 0.78 for 10-year change; P = 0.05) and those who used more self-controlled coping styles (OR 0.78 for 10-point change; P = 0.007) were less likely to be reluctant.

CONCLUSIONS
Awareness of elevated depressive symptoms is important in clinical practice given that these patients may be more reluctant to discuss self-care. Interventions and evidence-based approaches are needed to improve both depressive symptoms and physician-patient communication about self-care.
A Lower Cretaceous (Valanginian) seed cone provides the earliest fossil record for Picea (Pinaceae)
Authors: Klymiuk Ashley A. , Stockey Ruth A. 
Published: May 2012

• Premise of study: Sequence analyses for Pinaceae have suggested that extant genera diverged in the late Mesozoic. While the fossil record indicates that Pinaceae was highly diverse during the Cretaceous, there are few records of living genera. This description of an anatomically preserved seed cone extends the fossil record for Picea A. Dietrich (Pinaceae) by ∼75 Ma.• Methods: The specimen was collected from the Apple Bay locality of Vancouver Island (Lower Cretaceous, Valanginian) and is described from anatomical sections prepared using cellulose acetate peels. Cladistic analyses of fossil and extant pinaceous seed cones employed parsimony ratchet searches of an anatomical and morphological matrix.• Key results: This new seed cone has a combination of characters shared only with the genus Picea A. Dietr. and is thus described as Picea burtonii Klymiuk et Stockey sp. nov. Bisaccate pollen attributable to Picea is found in the micropyles of several ovules, corroborating the designation of this cone as an early spruce. Cladistic analyses place P. burtonii with extant Picea and an Oligocene representative of the genus. Furthermore, our analyses indicate that Picea is sister to Cathaya Chun et Kuang, and P. burtonii helps to establish a minimum date for this node in hypotheses of conifer phylogeny.• Conclusions: As an early member of the extant genus Picea, this seed cone extends the fossil record of Picea to the Valanginian Stage of the Early Cretaceous, ca. 136 Ma, thereby resolving a ghost lineage predicted by molecular divergence analyses, and offers new insight into the evolution of Pinaceae.
Caractéristiques hédoniques et changement environnemental : la couverture de l'autoroute A1
Authors: Calcoen Francis , Cornuel Didier , Leleu Hervé 
Published: May 2012

Résumé L’objectif de ce texte est d’identifier l’impact éventuel de la couverture de l’autoroute A1 à Saint-Denis sur les prix des logements. Cette couverture induit une réduction notable des nuisances et une amélioration manifeste du cadre urbain. La méthode utilisée est celle des caractéristiques hédoniques : elle consiste à quantifier la contribution des différentes caractéristiques d’un logement à la valeur de celui-ci. La couverture de l’A1 représente une nouvelle caractéristique des logements situés à proximité, et non la variation du volume d’une caractéristique existante. Pour tenir compte de cette caractéristique nouvelle et de son caractère commun à tous les logements de la zone, on a développé deux stratégies d’estimation différentes. La première considère l’impact global à l’aide de variables dichotomiques ; l’impact est alors chiffré à environ 16 % de la valeur moyenne des appartements dans la zone directement concernée. La seconde stratégie intègre la seule amélioration phonique mesurée par la réduction des décibels pour chaque appartement. Dans ce cas, la valorisation apportée est estimée entre 7 % et 8 % de la valeur d’un appartement directement situé sur l’autoroute couverte, et se réduit à 4 % de la valeur dans la proche périphérie de l’autoroute. L’impact est donc significatif, même s’il ne transforme pas radicalement le marché des logements existants.
L'efficacité d'une politique régionale de réduction du temps de travail
Authors: Delsart Virginie 
Published: May 2012

Résumé Y a-t-il, même dans des domaines qui restent de la compétence de l’État, un espace d’intervention pour des institutions comme les Régions ? Telle est la question examinée dans cet article au travers l’expérience originale du Nord - Pas-de-Calais en matière d’incitation à la réduction du temps de travail. Décidée en 1995 par le Conseil Régional, cette politique s’est combinée aux dispositifs nationaux (loi ROBIEN de juin 1996, loi AUBRY de juin 1998). L’analyse de ses résultats suggère une réponse positive à la question du bien fondé de politiques locales dans un domaine qui échappe normalement aux pouvoirs locaux (ici la régulation du marché du travail).
Les politiques d'accompagnement du péage urbain : étude sur l'acceptabilité en Suisse
Authors: Reymond Mathias 
Published: May 2012

Résumé Le présent document s’intéresse à l’épineuse question de l’acceptabilité du péage de congestion et aux politiques d’accompagnement à envisager pour le rendre plus acceptable aux yeux des citoyens. À partir d’une enquête récente réalisée en Suisse Romande, on effectue une analyse des correspondances multiples à l’aide du logiciel de traitement de données SPAD afin de regrouper des individus autour de différentes modalités (utilisation de la voiture, perception du péage, affectation des recettes du péage...). L’étude des graphiques fait ressortir plusieurs groupes dont deux fortement opposés : les automobilistes fréquents et les automobilistes occasionnels.
Surplus agricole, division du travail et émergence des villes
Authors: Spielvogel Gilles 
Published: May 2012

Résumé Dans ce papier, nous mettons en évidence les conditions économiques de l’émergence des villes dans un modèle d’équilibre général spatial. La présence de rendements croissants basés sur une division du travail, de coûts de transport et la possibilité de constitution d’un surplus agricole suffisent à rendre possibles différentes configurations d’équilibre urbain : économie sans ville, économie monocentrique stable et économie monocentrique instable.
Nasomaxillary complex in size, position and orientation in surgically treated and untreated individuals with cleft lip and palate: A cephalometric overview
Authors: Khanna Rohit , Tikku Tripti , Wadhwa Jitesh 
Published: May 2012

ABSTRACT
Background: This cross-sectional retrospective cephalometric study was designed to clarify whether the maxillary deficiency seen in surgically treated individuals with non-syndromic complete unilateral cleft lip and palate (UCLP) is due to inherent growth potential or iatrogenicity. Materials and Methods: 72 adult individuals were randomly selected in the age range of 12-20 years, and were divided into two groups. Group I had 47 untreated individuals. Group II consisted of 25 surgically treated individuals. Lateral and frontal cephalograms of the selected individuals were taken and analysed using Nemoceph software. Results: Group II showed a marked reduction in the cranial base angle, maxillary base length, anterior and posterior maxillary positions, palatal plane angle, maxillary width, maxillary height, occlusal plane height, nasal width and nasal height. Conclusion: Surgical intervention does interfere with growth in the facial region. This could be attributed to the scar tissue in lip and palate region, which has a restraining effect on growth in the facial region. These altered functional matrices play a significant role in determining the growth of facial structures.
Bilateral microvascular second toe transfer for bilateral post-traumatic thumb amputation
Authors: Nehete Rajendra , Nehete Anita , Singla Sandeep , Adhav Harshad 
Published: May 2012

ABSTRACTIn bilateral thumb amputations, the functional impairment is serious and every attempt should be made to reconstruct the thumb. We report a case of bilateral post traumatic thumb amputation, reconstructed with bilateral second toe transfer. Only two such cases have been reported in literature so far. Though there are various modalities for the reconstruction of thumb, microvascular toe transfer has its own merits. The convalescent period is minimal with excellent function. It is bilaterally symmetric and aesthetically superior to the osteoplastic reconstruction. The technical details are discussed, and the long term functional and aesthetic results are presented.
Oncology in Nepal
Authors: Piya Madan K , Acharya Sandhya C 
Published: May 2012

AbstractNepal being a developing country is lagging behind in almost all its healthcare services and hence Oncology is also in its primitive stages. In this review, effort is being made to outline the historical perspectives regarding evolution of Oncology in Nepal, with a brief overview of cancer scenario in the country. This review also highlights the challenges, constraints and successes that are associated in initiation and nurturing of Oncology in developing countries. It also emphasizes the history, current status, challenges of academic training in oncology and also portrays the effort of various national and international organisations and government trying to achieve recent advancements and expensive modern technology.
Thyroid cancer in Gardner’s syndrome: Case report and review of literature
Authors: Punatar Sachin B. , Noronha Vanita , Joshi Amit , Prabhash Kumar 
Published: May 2012

AbstractGardner′s syndrome is a variant of familial adenomatous polyposis. A multitude of extra-colonic manifestations including various endocrine tumors have been associated with this syndrome, the commonest of which is thyroid cancer. Majority of the patients with thyroid cancer and Gardner′s syndrome are females. Here we describe a male patient with Gardner′s syndrome who subsequently developed thyroid cancer.
Multipotent Stromal Stem Cells from Human Placenta Demonstrate High Therapeutic Potential
Authors: Nazarov Igor , Lee Jae W. , Soupene Eric , Etemad Sara , Knapik Derrick , Green William , Bashkirova Elizaveta , Fang Xiaohui , Matthay Michael A. , Kuypers Frans A. , Serikov Vladimir B. 
Published: May 2012

Abstract
We describe human chorionic mesenchymal stem cell (hCMSC) lines obtained from the chorion of human term placenta with high therapeutic potential in human organ pathology. hCMSCs propagated for more than 100 doublings without a decrease in telomere length and with no telomerase activity. Cells were highly positive for the embryonic stem cell markers OCT-4, NANOG, SSEA-3, and TRA-1–60. In vitro, cells could be differentiated into neuron-like cells (ectoderm), adipocytes, osteoblasts, endothelial-like cells (mesoderm), and hepatocytes (endoderm)—derivatives of all three germ layers. hCMSCs effectively facilitated repair of injured epithelium as demonstrated in an ex vivo-perfused human lung preparation injured by Escherichia coli endotoxin and in in vitro human lung epithelial cultures. We conclude that the chorion of human term placenta is an abundant source of multipotent stem cells that are promising candidates for cell-based therapies.
Amyotrophic Lateral Sclerosis Model Derived from Human Embryonic Stem Cells Overexpressing Mutant Superoxide Dismutase 1
Authors: Wada Tamaki , Goparaju Sravan K. , Tooi Norie , Inoue Haruhisa , Takahashi Ryosuke , Nakatsuji Norio , Aiba Kazuhiro 
Published: May 2012

Abstract
The generation of amyotrophic lateral sclerosis (ALS) disease models is an important subject for investigating disease mechanisms and pharmaceutical applications. In transgenic mice, expression of a mutant form of superoxide dismutase 1 (SOD1) can lead to the development of ALS that closely mimics the familial type of ALS (FALS). Although SOD1 mutant mice show phenotypes similar to FALS, dissimilar drug responses and size differences limit their usefulness to study the disease mechanism(s) and identify potential therapeutic compounds. Development of an in vitro model system for ALS is expected to help in obtaining novel insights into disease mechanisms and discovery of therapeutics. We report the establishment of an in vitro FALS model from human embryonic stem cells overexpressing either a wild-type (WT) or a mutant SOD1 (G93A) gene and the evaluation of the phenotypes and survival of the spinal motor neurons (sMNs), which are the neurons affected in ALS patients. The in vitro FALS model that we developed mimics the in vivo human ALS disease in terms of the following: (a) selective degeneration of sMNs expressing the G93A SOD1 but not those expressing the WT gene; (b) susceptibility of G93A SOD1-derived sMNs to form ubiquitinated inclusions; (c) astrocyte-derived factor(s) in the selective degeneration of G93A SOD1 sMNs; and (d) cell-autonomous, as well as non-cell-autonomous, dependent sMN degeneration. Thus, this model is expected to help unravel the disease mechanisms involved in the development of FALS and also lead to potential drug discoveries based on the prevention of neurodegeneration.
Concise Review: Bone Marrow Mononuclear Cells for the Treatment of Ischemic Syndromes: Medicinal Product or Cell Transplantation?
Authors: Cuende Natividad , Rico Laura , Herrera Concha 
Published: May 2012

Abstract
In November of 2011, the Committee for Advanced Therapies (CAT) of the European Medicines Agency (EMA) published two scientific recommendations regarding the classification of autologous bone marrow-derived mononuclear cells (BM-MNCs) and autologous bone marrow-derived CD133+ cells as advanced therapy medicinal products (ATMPs), specifically tissue-engineered products, when intended for regeneration in ischemic heart tissue on the basis that they are not used for the same essential function (hematological restoration) that they fulfill in the donor. In vitro and in vivo evidence demonstrates that bone marrow cells are physiologically involved in adult neovascularization and tissue repair, making their therapeutic use for these purposes a simple exploitation of their own essential functions. Therefore, from a scientific/legal point of view, nonsubstantially manipulated BM-MNCs and CD133+ cells are not an ATMP, because they have a physiological role in the processes of postnatal neovascularization and, when used therapeutically for vascular restoration in ischemic tissues, they are carrying out one of their essential physiological functions (the legal definition recognizes that cells can have several essential functions). The consequences of classifying BM-MNCs and CD133+ cells as medicinal products instead of cellular transplantation, like bone marrow transplantation, in terms of costs and time for these products to be introduced into clinical practice, make this an issue of crucial importance. Therefore, the recommendations of EMA/CAT could be reviewed in collaboration with scientific societies, in light of organizational and economic consequences as well as scientific knowledge recently acquired about the mechanisms of postnatal neovascularization and the function of bone marrow in the regeneration of remote tissues.
Gold Functionalized Mesoporous Silica Nanoparticle Mediated Protein and DNA Codelivery to Plant Cells Via the Biolistic Method
Authors: Martin‐Ortigosa Susana , Valenstein Justin S. , Lin Victor S.‐Y. , Trewyn Brian G. , Wang Kan 
Published: May 2012

AbstractThe synthesis and characterization of a gold nanoparticle functionalized mesoporous silica nanoparticle (Au‐MSN) platform for codelivery of proteins and plasmid DNA to plant tissues using a biolistic particle delivery system is reported. The in vitro uptake and release profiles of fluorescently labeled bovine serum albumin (BSA) and enhanced green fluorescent protein (eGFP) are investigated. As a proof‐of‐concept demonstration, Au‐MSN with large average pore diameters (10 nm) are shown to deliver and subsequently release proteins and plasmid DNA to the same cell after passing through the plant cell wall upon bombardment. Release of fluorescent eGFP indicates the delivery of active, non‐denatured proteins to plant cells. This advance represents the first example of biolistic‐mediated codelivery of proteins and plasmid DNA to plant cells via gold‐functionalized MSN and provides a powerful tool for both fundamental and applied research of plant sciences.
Formation of a Continuous Solid‐Solution Particle and its Application to Rechargeable Lithium Batteries
Authors: Noh Hyung‐Joo , Myung Seung‐Taek , Jung Hun‐Gi , Yashiro Hitoshi , Amine Khalil , Sun Yang‐Kook 
Published: May 2012

AbstractHigh‐energy electrode materials are under worldwide development for rechargeable lithium batteries to be used in electric vehicles and other energy storage applications. High capacity and energy density are readily achievable using Ni‐rich Li[Ni1‐xMx]O2 (x = 0.1–0.2, M = Ni, Co, Mn, and Al) cathodes. Unfortunately, their structural instability is associated with severe capacity fading on cycling, which hinders practical applications. Here, a method is presented for producing a continuous compositional change between Li[Ni0.8Co0.2]O2 (center) and Li[Ni0.8Co0.01Mn0.19]O2 (surface) in a spherical particle, resulting in an average composition of Li[Ni0.8Co0.06Mn0.14]O2. The chemical composition in the particle is gradually altered by decreasing the Co concentration while adding Mn content. The Ni content remains fixed. Coin cells with the solid‐solution cathode deliver a specific capacity over 210 mAh g−1 in the voltage range of 2.7–4.3 V vs. Li/Li+ with capacity retention of 85% over 100 cycles at 25 and 55 °C. The main exothermic temperature upon heating appears at around 250 °C with relatively low heat generation (810 J g−1). The presence of the tetravalent Mn at the particle surface is mainly responsible for the high capacity upon cycling and excellent thermal properties.
Determinants of high weight gain and high BMI status in the first three months in urban Chinese infants
Authors: Zhang Jianduan , Jiang Jingxiong , Himes John H. , Zhang Jing , Liu Guoyan , Huang Xiaona , Guo Yuan , Shi Junxin , Shi Shuhua 
Published: May 2012

AbstractObjectives:Investigate the potential factors associated with high weight gain and high BMI status in the first three months of life.Methods:Totally, 930 healthy neonates (489 boys and 441 girls) were involved in this community‐based, prospective study in China. Data on body weight and length were collected at birth, and the 1st and 3rd months. A self‐administered questionnaire was used to collect data regarding social demography, gestational status, delivery, and the feeding patterns of children.Results:Prevalences of high BMI status (BMI = 85th p, re WHO BMI standards) increased over time in both sexes, reaching 24.5% and 12.0% for boys and girls, respectively. General linear mixed models indicate high BMI status at 3 months is significantly and inversely associated with breastfeeding, as a proportion of feeding occasions [OR 0.74 (95%CI: 0.56–0.98)] and positively with lower birth weight [OR 2.07 (95%CI: 1.23–3.49)]. High weight gain (=85th p, re WHO velocity standards) in the first 3 months is also significantly associated with breastfeeding [OR 0.76 (95%CI: 0.59–0.96)] and sex, with boys at a higher risk than girls [OR 1.44 (95%CI: 1.07–1.97)]. Living in an extended family is associated with both high weight gain and high BMI status, but with marginal statistical significance.Conclusion:Analyses indicate an increasing trend of high BMI status in early infancy. Breastfeeding provides a protective effect for both high weight gain and high BMI status. The results concerning birth weight suggests a target for intervention.Am. J. Hum. Biol., 2012. ©2012 Wiley Periodicals, Inc.
Cancer morbidity of professional emergency responders in Korea
Authors: Ahn Yeon‐Soon , Jeong Kyoung‐Sook , Kim Kyoo‐Sang 
Published: May 2012

AbstractBackgroundMany professional emergency responders (ERs) who belong to the Korean National Emergency Management Agency (NEMA) have been cross‐trained and serve multiple roles. As such, firefighters and other ERs in Korea are exposed to similar occupational hazards. This study was conducted to estimate cancer morbidity in male ERs and compare that with Korean men.MethodsThe cohort was comprised of 33,416 male ERs working between 1980 and 2007, who were alive on December 31, 1995. Work histories were merged with the Korea National Central Cancer Registry (KNCCR) to assess cancer morbidity between 1996 and 2007. Standardized incidence ratios (SIRs) with reference to Korean men were analyzed.ResultsSIRs with reference to national cancer rates were not significantly decreased for overall cancer (SIR = 0.97, 95% CI = 0.90–1.08) in all ERs. However, colorectal (SIR = 1.35, 95% CI = 1.07–1.67), kidney (SIR = 1.59, 95% CI = 1.00–2.41), and bladder (SIR = 1.77, 95% CI = 1.08–2.73) cancer, and non‐Hodgkin's lymphoma (SIR = 1.81, 95% CI = 1.12–2.76) morbidities were significantly increased among all ERs. In firefighters, significantly increased cancer types were as same as those of all ERs. In non‐firefighter ERs, colorectal (SIR = 2.51, 95% CI = 1.20–4.61) and bone and articular cartilage cancers (SIR = 9.53, 95% CI = 1.07–34.41) were significantly higher than those of Korean men.ConclusionsKorean firefighters showed excess morbidity in several cancer types, including colorectal and urologic cancers, and non‐Hodgkin's lymphoma, demonstrating similar trends to previous studies for firefighters conducted in other countries. Increased incidence in these cancer types suggests occupational exposure to carcinogens and shift work. Am. J. Ind. Med. 55:768–778, 2012. © 2012 Wiley Periodicals, Inc.