bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracorporeal cardiopulmonary resuscitation for patients with refractory out-of-hospital cardiac arrest: a propensity score matching, observational study
Authors: Shih Hong-Mo , Lin Wei-Jun , Lin You-Cian , Chang Shih-Sheng , Chang Kuan-Cheng , Yu Shao-Hua 
Published: April 2024

AbstractExtracorporeal cardiopulmonary resuscitation (ECPR) is increasingly performed as an adjunct to conventional cardiopulmonary resuscitation (CCPR) for refractory out-of-hospital cardiac arrest (OHCA). However, the specific benefits of ECPR concerning survival with favorable neurological outcomes remain uncertain. This study aimed to investigate the potential advantages of ECPR in the management of refractory OHCA. We conducted a retrospective cohort study involved OHCA patients between January 2016 and May 2021. Patients were categorized into ECPR or CCPR groups. The primary endpoint assessed was survival with favorable neurological outcomes, and the secondary outcome was survival rate. Multivariate logistic regression analyses, with and without 1:2 propensity score matching, were employed to assess ECPR’s effect. In total, 1193 patients were included: 85underwent ECPR, and 1108 received CCPR. Compared to the CCPR group, the ECPR group exhibited notably higher survival rate (29.4% vs. 2.4%; p < 0.001). The ECPR group also exhibited a higher proportion of survival with favorable neurological outcome than CCPR group (17.6% vs. 0.7%; p < 0.001). Multivariate logistic regression analysis demonstrated that ECPR correlated with increased odds of survival with favorable neurological outcome (adjusted odds ratio: 13.57; 95% confidence interval (CI) 4.60–40.06). Following propensity score matching, the ECPR group showed significantly elevated odds of survival with favorable neurological outcomes (adjusted odds ratio: 13.31; 95% CI 1.61–109.9). This study demonstrated that in comparison to CCPR, ECPR may provide survival benefit and increase the odds of favorable neurological outcomes in selected OHCA patients.
Exploring mosquito abundance and Plasmodium infection through nested-PCR: implications for disease surveillance and control
Authors: Abbas Haider , Sajid Muhammad S. , Rizwan Hafiz M. , Tahir Urfa B. , Farooqi Shahid H. , Iqbal Zeeshan , Malik Muhammad A. , Yaseen Kashaf , Maqbool Mahvish , Raza Faiz A. , Raza Mohsin , Fouad Dalia , Ataya Farid S. 
Published: April 2024

AbstractThe Plasmodium is responsible for malaria which poses a major health threat, globally. This study is based on the estimation of the relative abundance of mosquitoes, and finding out the correlations of meteorological parameters (temperature, humidity and rainfall) with the abundance of mosquitoes. In addition, this study also focused on the use of nested PCR (species-specific nucleotide sequences of 18S rRNA genes) to explore the Plasmodium spp. in female Anopheles. In the current study, the percentage relative abundance of Culex mosquitoes was 57.65% and Anopheles 42.34% among the study areas. In addition, the highest number of mosquitoes was found in March in district Mandi Bahauddin at 21 °C (Tmax = 27, Tmin = 15) average temperature, 69% average relative humidity and 131 mm rainfall, and these climatic factors were found to affect the abundance of the mosquitoes, directly or indirectly. Molecular analysis showed that overall, 41.3% of the female Anopheles pools were positive for genus Plasmodium. Among species, the prevalence of Plasmodium (P.) vivax (78.1%) was significantly higher than P. falciparum (21.9%). This study will be helpful in the estimation of future risk of mosquito-borne diseases along with population dynamic of mosquitoes to enhance the effectiveness of vector surveillance and control programs.
All-optical 3D blue phase photonic crystal switch with photosensitive dopants
Authors: Oton Eva , Cigl Martin , Morawiak Przemysław , Mironov Sergei , Bubnov Alexej , Piecek Wiktor 
Published: April 2024

AbstractBlue phase (BP) liquid crystals (LC) have lately become the focus of extensive research due to their peculiar properties and structure. BPs exhibit a highly organized 3D structure with a lattice period in the hundreds of nm. Owing to such structure, BPs are regarded as 3D photonic crystals. The unique properties of this complex LC phase are achieved by the self-assembly of the LC molecules into periodic cubic structures, producing bright selective Bragg reflections. Novel applications involving 3D photonic crystals would certainly benefit from enhanced ground-breaking functionalities. However, the use of BPs as 3D has been traditionally curtailed by the BP crystals trend to grow as random polycrystals, making it difficult to develop practical BP-based photonic devices. The possibility of generating mm-sized BP monocrystals was recently demonstrated. However, besides increasing the scarce number of 3D photonic structural materials, their applications as 3D photonic crystals do not show apparent advantages over other solid materials or metamaterials. Having a tunable BP monocrystal, where crystals could be switched, modulating simultaneously some of their properties as 3D photonic crystals, they would constitute a new family of materials with superior performance to other existing materials, opening up a plethora of new applications. In this work, an all-optical switchable 3D photonic crystal based on BPs doped with tailored photoactive molecules is demonstrated. Two switching modes have been achieved, one where the BP reversibly transitions between two BP phases, BPI and BPII, (two different cubic crystal systems) while maintaining the monocrystallinity of the whole system. The second mode, again reversible, switches between BPI and isotropic state. None of these modes are related to the regular thermal transitions between LC phases; switching is triggered by light pulses of different wavelengths. This all-optical approach allows for a seamless fast remotely controlled optical switch between two 3D photonic crystals in different cubic crystal systems and between a photonic crystal and an isotropic matrix. Applications of switchable BPs for adaptive optics systems or photonic integrated circuits would make great advances using 3D photonic crystal switches. All-optical photonic systems such as these hold great promise for the development of tunable and efficient photonic devices such as dynamic optical filters and sensors, as they enable light-driven modulation and sensing applications with unprecedented versatility.
Development of a novel high-throughput culture system for hypoxic 3D hydrogel cell culture
Authors: Egger Dominik , Baier Luisa , Moldaschl Julia , Taschner Manfred , Lorber Volker , Kasper Cornelia 
Published: April 2024

AbstractAnimal models lack physiologic relevance to the human system which results in low clinical translation of results derived from animal testing. Besides spheroids or organoids, hydrogel-based 3D in vitro models are used to mimic the in vivo situation increasing the relevance while reducing animal testing. However, to establish hydrogel-based 3D models in applications such as drug development or personalized medicine, high-throughput culture systems are required. Furthermore, the integration of oxygen-reduced (hypoxic) conditions has become increasingly important to establish more physiologic culture models. Therefore, we developed a platform technology for the high-throughput generation of miniaturized hydrogels for 3D cell culture. The Oli-Up system is based on the shape of a well-plate and allows for the parallel culture of 48 hydrogel samples, each with a volume of 15 µl. As a proof-of-concept, we established a 3D culture of gelatin-methacryloyl (GelMA)-encapsulated mesenchymal stem/stromal cells (MSCs). We used a hypoxia reporter cell line to establish a defined oxygen-reduced environment to precisely trigger cellular responses characteristic of hypoxia in MSCs. In detail, the expression of hypoxia response element (HRE) increased dependent on the oxygen concentration and cell density. Furthermore, MSCs displayed an altered glucose metabolism and increased VEGF secretion upon oxygen-reduction. In conclusion, the Oli-Up system is a platform technology for the high-throughput culture of hydrogel-based 3D models in a defined oxygen environment. As it is amenable for automation, it holds the potential for high-throughput screening applications such as drug development and testing in more physiologic 3D in vitro tissue models.
Structural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites
Authors: Liu Kun , Wu Cang , Zhu Mingyue , Xu Junnv , Lin Bo , Lin Haifeng , Liu Zhongmin , Li Mengsen 
Published: April 2024

AbstractAlpha-fetoprotein (AFP), a serum glycoprotein, is expressed during embryonic development and the pathogenesis of liver cancer. It serves as a clinical tumor marker, function as a carcinogen, immune suppressor, and transport vehicle; but the detailed AFP structural information has not yet been reported. In this study, we used single-particle cryo-electron microscopy(cryo-EM) to analyze the structure of the recombinant AFP obtained a 3.31 Å cryo-EM structure and built an atomic model of AFP. We observed and identified certain structural features of AFP, including N-glycosylation at Asn251, four natural fatty acids bound to distinct domains, and the coordination of metal ions by residues His22, His264, His268, and Asp280. Furthermore, we compared the structural similarities and differences between AFP and human serum albumin. The elucidation of AFP’s structural characteristics not only contributes to a deeper understanding of its functional mechanisms, but also provides a structural basis for developing AFP-based drug vehicles.
Direct esterification of amides by the dimethylsulfate-mediated activation of amide C–N bonds
Authors: Qin Hongjian , Han Zijian , Bonku Emmanuel Mintah , Sun Haiguo , Odilov Abdullajon , Zhu Fuqiang , Abduahadi Safomuddin , Zhu Weiliang , Shen Jingshan , Aisa Haji A. 
Published: April 2024

AbstractAmides are important intermediates in organic chemistry and the pharmaceutical industry, but their low reactivity requires catalysts and/or severe reaction conditions for esterification. Here, a novel approach was devised to convert amides into esters without the use of transition metals. The method effectively overcomes the inherent low reactivity of amides by employing dimethylsulfate-mediated reaction to activate the C-N bonds. To confirm the proposed reaction mechanism, control experiments and density functional theory (DFT) calculations were conducted. The method demonstrates a wide array of substrates, including amides with typical H/alkyl/aryl substitutions, N,N-disubstituted amides, amides derived from alkyl, aryl, or vinyl carboxylic acids, and even amino acid substrates with stereocentres. Furthermore, we have shown the effectiveness of dimethylsulfate in removing acyl protective groups in amino derivatives. This study presents a method that offers efficiency and cost-effectiveness in broadening the esterification capabilities of amides, thereby facilitating their increased utilization as synthetic compounds in diverse transformations.
Safety control strategy of spinal lamina cutting based on force and cutting depth signals
Authors: Zhang Jian , Zhang Yonghong , Liu Shanshan , Ji Xuquan , Liu Sizhuo , Li Zhuofu , Geng Baoduo , Li Weishi , Wang Tianmiao 
Published: April 2024

AbstractLaminectomy is one of the most common posterior spinal operations. Since the lamina is adjacent to important tissues such as nerves, once damaged, it can cause serious complications and even lead to paralysis. In order to prevent the above injuries and complications, ultrasonic bone scalpel and surgical robots have been introduced into spinal laminectomy, and many scholars have studied the recognition method of the bone tissue status. Currently, almost all methods to achieve recognition of bone tissue are based on sensor signals collected by high‐precision sensors installed at the end of surgical robots. However, the previous methods could not accurately identify the state of spinal bone tissue. Innovatively, the identification of bone tissue status was regarded as a time series classification task, and the classification algorithm LSTM‐FCN was used to process fusion signals composed of force and cutting depth signals, thus achieving an accurate classification of the lamina bone tissue status. In addition, it was verified that the accuracy of the proposed method could reach 98.85% in identifying the state of porcine spinal laminectomy. And the maximum penetration distance can be controlled within 0.6 mm, which is safe and can be used in practice.
Optimal coordinated energy management in active distribution networks considering battery energy storage and price‐responsive demand
Authors: Thokar Rayees Ahmad , Gupta Nikhil , Niazi K. R. , Swarnkar Anil , Meena Nand K. , Yang Jin 
Published: April 2024

AbstractContemporary distribution networks can be seen with diverse dispatchable and non‐dispatchable energy resources. The coordinated scheduling of these dispatchable resources with non‐dispatchable resources can provide several techno‐economic and social benefits. Since battery energy storage systems (BESSs) and microturbine units are capital intensive. A thorough investigation of their coordinated scheduling on a purely economic basis will be an interesting and challenging task while considering dynamic electricity price and uncertainty of renewable power generation and load demand. This paper proposes a new methodology for optimal coordinated scheduling of BESSs and microturbine units considering existing renewable energy resources and dynamic electricity price to maximize daily profit function of the utility. In this study, a recently explored modified African buffalo optimization algorithm is employed. The key attributes of the proposed methodology are comprised of mean price‐based adaptive scheduling embedded within a decision mechanism system to maximize arbitrage benefits. Decision mechanism system keeps a track of system states as a‐priori thus guides the artificial intelligence‐based solution technique for sequential optimization. This may also reduce the computational burden of complex real‐life engineering optimization problems. Further, a novel concept of fictitious charges in coordination with BESS management algorithm is proposed to restrict the counterproductive operational management of BESSs. The application results investigated and compared on a benchmark 33‐bus test distribution system highlights the importance of the proposed methodology.
Using conditional Invertible Neural Networks to perform mid‐term peak load forecasting
Authors: Heidrich Benedikt , Hertel Matthias , Neumann Oliver , Hagenmeyer Veit , Mikut Ralf 
Published: April 2024

AbstractMeasures for balancing the electrical grid, such as peak shaving, require accurate peak forecasts for lower aggregation levels of electrical loads. Thus, the Big Data Energy Analytics Laboratory (BigDEAL) challenge—organised by the BigDEAL—focused on forecasting three different daily peak characteristics in low aggregated load time series. In particular, participants of the challenge were asked to provide long‐term forecasts with horizons of up to 1 year in the qualification. The authors present the approach of the KIT‐IAI team from the Institute for Automation and Applied Informatics at the Karlsruhe Institute of Technology. The approach to the challenge is based on a hybrid generative model. In particular, the authors use a conditional Invertible Neural Network (cINN). The cINN gets the forecast of a sliding mean as representative of the trend, different weather features, and calendar information as conditioning input. By this, the proposed hybrid method achieved second place overall and won two out of three tracks of the BigDEAL challenge.
Type III Vasa Previa Associated with Resolution of a Low-Lying Placenta: Case Report and Literature Review
Authors: Kim Joanna J. , Bonhomme Katherine , Oppenheimer Lawrence W. , Gaudet Laura 
Published: April 2024

AbstractVasa previa occurs when fetal vessels lie above the cervical os. A novel type of vasa previa, known as type III, is characterized by an abnormal branching of fetal vessels from the placenta in the absence of velamentous cord insertion (as seen in type I) or multilobed placenta (as seen in type II). Here, we present a case of a type III vasa previa after a resolution of a low-lying placenta. The presence of any known risk factors of vasa previa, including low-lying placenta, should prompt screening for vasa previa in the third trimester. Accurate and timely diagnosis of vasa previa will confer significant survival benefit for the neonate.
Stepping Up Recovery: Integrating Patient-reported Outcome Measures and Wearable Technology for Rehabilitation Following Knee Arthroplasty
Authors: Pasqualini Ignacio , Huffman Nickelas , Klika Alison , Kamath Atul F. , Higuera-Rueda Carlos A. , Deren Matthew E. , Murray Trevor G. , Piuzzi Nicolas S. 
Published: April 2024

AbstractImprovement after knee arthroplasty (KA) is often measured using patient-reported outcome measures (PROMs). However, PROMs are limited due to their subjectivity. Therefore, wearable technology is becoming commonly utilized to objectively assess physical activity and function. We assessed the correlation between PROMs and step/stair flight counts in total (TKA) and partial knee arthroplasty (PKA) patients.Analysis of a multicenter, prospective, longitudinal cohort study investigating the collection of average daily step and stair flight counts, was performed. Subjects (N = 1,844 TKA patients and N = 489 PKA patients) completed the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR) and provided numerical rating scale pain scores pre- and postoperatively. Only patients who reported living in a multilevel home environment (N = 896 TKA patients and N = 258 PKA patients) were included in analysis of stair flight counts. Pearson correlation coefficients were calculated to determine correlations between variables.Among TKA patients, pain scores demonstrated a negative correlation to mean step counts at preoperative (r = −0.14, p < 0.0001) and 1-month follow-up (r = −0.14, p < 0.0001). Similar negative correlations were true for pain and stair flight counts at preoperative (r = −0.16, p < 0.0001) and 1-month follow-up (r = −0.11, p = 0.006). KOOS JR scores demonstrated weak positive correlations with mean step counts at preoperative (r = 0.19, p < 0.0001) and 1-month postoperative (r = 0.17, p < 0.0001). Similar positive correlations were true for KOOS JR scores and stair flight counts preoperatively (r = 0.13, p = 0.0002) and at 1-month postoperatively (r = 0.10, p = 0.0048). For PKA patients, correlations between pain and KOOS JR with step/stair counts demonstrated similar directionality.Given the correlation between wearable-generated data and PROMs, wearable technology may be beneficial in evaluating patient outcomes following KA. By combining subjective feedback with the objective data, health care providers can gain a holistic view of patients' progress and tailor treatment plans accordingly.
Preconditioning Local Injection of Activated Platelet-Rich Plasma Increases Angiogenesis, VEGF Levels, and Viability of Modified McFarlane Flap in Diabetes-Induced Rats
Authors: Kamayana Jenisa Amanda Sandiarini , Hamid Agus Roy Rusly Hariantana , Mahadewa Tjokorda Gde Bagus , Sanjaya I. Gusti Putu Hendra , Darmajaya I. Made , Dewi I. Gusti Ayu Sri Mahendra 
Published: April 2024

Abstract
Background The risk of flap necrosis in tissue reconstruction surgery is elevated in patients with vascular disorders, such as diabetes mellitus. Chronic hyperglycemia causes endothelial cell dysfunction and increases inflammatory process, causing vascular insufficiency. Platelet-rich plasma (PRP) contains high levels of platelets, growth factors, and fibrinogens. Its regenerative properties spark interest in supporting flap survival in relation to diabetic complications.
Methods Thirty Wistar rats were divided into three groups. The first group included diabetic rats without PRP injection, which underwent flap procedure. The second group included diabetes-induced rats receiving PRP subcutaneous injection 1 day prior to flap procedure. The third group included nondiabetic rats receiving PRP injection 1 day prior to flap procedure. Flap tissue samples were taken on the seventh day to measure vascular endothelial growth factor (VEGF) levels using enzyme-linked immunosorbent assay method; angiogenesis and collagen density were measured from histopathology examination, and flap viability was analyzed using digital measurements.
Results Analysis showed that flap viability, angiogenesis, and VEGF levels were significantly higher in the PRP-injected diabetic rats compared with diabetic rats that did not receive PRP. The levels of VEGF, angiogenesis, and viability of flaps in diabetic rats given PRP did not differ significantly compared with nondiabetic rats that received PRP.
Conclusion Flap preconditioning through local injection of activated PRP enhances flap viability, VEGF levels and angiogenesis, in random skin flaps in diabetic rats, to the level where it does not differ significantly to nondiabetic rats that were given PRP.
Osbert of Clare and the reforging of Westminster Abbey’s past
Authors: England Jennie M. 
Published: April 2024

AbstractTwelfth-century Westminster Abbey was a centre of forgery production: its scriptorium not only produced charters claiming rights and privileges for its own house but also contributed to the production of spurious documents for other English monasteries. Among these forgeries, the distinctive draftsmanship of one monk—Osbert of Clare—has been traced in some of Westminster’s longer and more elaborate creations. But Osbert was more than a forger, he also wrote hagiographical Lives of saints, including that of Edward the Confessor, whose cult he fiercely championed. Osbert’s different identities have long been recognised, but never reconciled. This essay investigates both Osbert’s forgeries and hagiography, and in doing so reveals that it is only by considering these different genres of writing together that Osbert’s (and his abbey’s) ambitions can be fully recognised. In particular, it appears that Osbert’s forgeries sought to claim prestige for Westminster not only through their contents, but also through the memories they invoked and invented.