bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eocene raoellids (Mammalia, Cetartiodactyla) outside the Indian Subcontinent: palaeogeographical implications
Authors: ORLIAC M. J. , DUCROCQ S. 
Published: July 2011

AbstractRaoellidae are small fossil cetartiodactyls closely related to the Cetacea. Until now undisputable raoellid remains were reported only from the early Middle Eocene of the Indian Subcontinent, although this Indo-Pakistani endemism has been challenged by several recent works describing potential raoellids from Mongolia, Myanmar and China. In this contribution we address the question of raoellid taxonomic content and definition, through a revision of the dental features of the family. This work, which includes a revision of the putative raoellid material from outside Indo-Pakistan, is primarily based on a re-examination of ‘suoid’ specimens from Shanghuang (Middle Eocene, coastal China). Our results indicate that the Shanghuang material both substantiates the youngest and easternmost occurrence of Raoellidae and represents the only unquestionable record of raoellids outside the Indian Subcontinent at present. This significantly extends the geographical and chronological range of the family. The occurrence of a raoellid species in the Middle Eocene of coastal China implies that raoellids dispersed from the Indian Subcontinent to eastern Asia during Early or Middle Eocene time. This tempers classical hypotheses of Middle Eocene Indian endemism and eastern Asian provincialism.
Contingent Credibility: The Impact of Investment Treaty Violations on Foreign Direct Investment
Authors: Allee Todd , Peinhardt Clint 
Published: July 2011

AbstractDuring the past few decades governments have signed nearly 2,700 bilateral investment treaties (BITs) with one another in an attempt to attract greater levels of foreign direct investment (FDI). By signing BITs, which contain strong enforcement provisions, investment-seeking governments are thought to more credibly commit to protecting whatever FDI they receive, which in turn should lead to increased confidence among investors and ultimately greater FDI inflows. Our unique argument is that the ability of BITs to increase FDI is contingent on the subsequent good behavior of the governments who sign them. BITs should increase FDI only if governments actually follow through on their BIT commitments; that is, if they comply with the treaties. BITs allow investors to pursue alleged treaty violations through arbitration venues like the International Centre for the Settlement of Investment Disputes (ICSID), a heavily utilized and widely observed arbitral institution that is part of the World Bank. Being taken before ICSID, then, conveys negative information about a host country's behavior to the broader investment community, which could result in a sizeable loss of future FDI into that country. We test these contingent effects of BITs using cross-sectional, time-series analyses on all non-OECD countries during a period spanning 1984–2007. We find that BITs do increase FDI into countries that sign them, but only if those countries are not subsequently challenged before ICSID. On the other hand, governments suffer notable losses of FDI when they are taken before ICSID and suffer even greater losses when they lose an ICSID dispute.
The Effect of Sanctions on U.S. Foreign Direct Investment
Authors: Biglaiser Glen , Lektzian David 
Published: July 2011

AbstractFor years, the United States has imposed economic sanctions to compel countries to alter their behavior. An important concern is whether government sanctions influence private foreign direct investment (FDI) decisions, the largest source of foreign capital. In the first study to assess empirically the relationship between economic sanctions and FDI, we consider whether U.S. sanctions influence U.S. FDI inflows into targeted countries. Using panel data for 171 countries from 1965 to 2000, we find strong evidence that U.S investors pull out of countries targeted for U.S sanctions prior to their imposition. This disinvestment is not permanent and investment tends to return after the sanctions are imposed. The results provide support for FDI studies that show the effect of risk on investor decision making.
Multilateralism and Democracy: A Dissent Regarding Keohane, Macedo, and Moravcsik
Authors: Gartzke Erik , Naoi Megumi 
Published: July 2011

AbstractIn an article printed last year inInternational Organization, Keohane, Macedo, and Moravcsik argued that multilateral organizations (MLO) could actually be good for democracy. We argue that KMM discount the prospect that MLO influence can be detrimental to democracies not because MLOs are “distant, elitist, and technocratic” but precisely because MLOs are highly political. International organizations have much to offer in improving the welfare of citizens and facilitating coordinations among states. They are not likely to improve procedural functions of democracies without a cost that itself is problematic for democracy.
GEOGRAPHICAL VARIATION AND MIGRATION ANALYSIS OF HEIGHT, WEIGHT AND BODY MASS INDEX IN A BRITISH COHORT STUDY
Authors: KRZYŻANOWSKA MONIKA , MASCIE-TAYLOR C. G. NICHOLAS 
Published: July 2011

SummaryUsing a sample of 2090 father and son pairs, the regional variation in height, weight and body mass index (BMI) with intra- and inter-generational migration within Britain was examined. Highly significant regional differences in means were found only for fathers. The overall mean height difference between regions ranged from about 2.7 cm to 3.1 cm, with the tallest fathers being found in the East & South-East region and the shortest in Wales. The variation in mean weight between regions was less significant, with the difference between the heaviest region (West Midlands) and lightest (South-West) being about 3.5 kg. For BMI the highest mean was in the North and Wales and the lowest in the South-West (difference of about 1 kg m−2). Intra-generational migrants were, on average, significantly taller than non-migrants for both fathers (+1.4 cm) and sons (+2 cm), but BMI was only significant in fathers, with migrant fathers, on average, having a lower BMI. There were no significant differences in weight between geographically mobile groups for either fathers or sons. Differentiating between regional in- and out-migration revealed that in the fathers' generation in-migrants were taller, on average, in six of the nine regions. The tallest in-migrants among fathers came into the North region; the tallest out-migrants were from Yorkshire & Humberside and the shortest were from Scotland. The largest positive gain on fathers' height was in the West Midlands region and Scotland, while negative effects were found in the Yorkshire & Humberside, East Midlands and East & South-East regions. For sons in-migrants were taller in all regions except Wales, with the largest differences between in-migrants and non-migrants being in the South-East and South-West. For out-migrants, the tallest sons came from Wales, while the shortest came from the East Midlands region. The North, East Midlands, East & South-East and West Midlands regions were net gainers, while Wales and Scotland were net losers. For BMI among fathers, in-migrants were of lower BMI than non-migrants. For out-migrant fathers, the North-West and South-West regions were the only two regions showing positive values, with the largest negative values being found in the East Midlands and Yorkshire & Humberside. The net effect of migration indicated that the largest gains were in the East Midlands and Yorkshire & Humberside regions and the largest losses were in Scotland and Wales. The inter-generational migration for BMI showed that in-migrating sons into the North-West and Wales had higher BMI than sedentes, while in-migrants into Yorkshire & Humberside were lower in BMI. In all regions out-migrants had lower BMI than non-migrants. The net effect of migration revealed that six of the nine regions were net gainers, while the Yorkshire & Humberside region was a net loser.
The anthelmintic efficacy of papaya latex in a rodent–nematode model is not dependent on fasting before treatment
Authors: Luoga W. , Mansur F. , Buttle D.J. , Duce I.R. , Garnett M.C. , Behnke J.M. 
Published: July 2011

AbstractIn earlier studies of the anthelmintic activity of plant cysteine proteinases (CPs), a period of food deprivation was routinely employed before administration of CPs, but there has been no systematic evaluation as to whether this does actually benefit the anthelmintic efficacy. Therefore, we assessed the effect of fasting on the efficacy of CPs from papaya latex (PL) against Heligmosomoides bakeri in C3H mice. We used a refined, supernatant extract of papaya latex (PLS) with known active enzyme content. The animals were divided into three groups (fasted prior to treatment with PLS, not fasted but treated with PLS and fasted but given only water). The study demonstrated clearly that although food deprivation had been routinely employed in much of the earlier work on CPs in mice infected with nematodes, fasting has no beneficial effect on the efficacy of PLS against H. bakeri infections. Administration of CPs to fed animals will also reduce the stress associated with fasting.
Vitamin B12 deficiency: an unusual cause of vocal fold palsy
Authors: Green R , Kara N , Cocks H 
Published: July 2011

AbstractObjective:We report an extremely rare case of vocal fold palsy secondary to vitamin B12 deficiency.Method:Case report and English-Language review of the world literature concerning vitamin B12 deficiency and its neurological manifestations. We discuss the physiological role of vitamin B and its specific relationship to the presented patient's symptoms.Results:We describe a rare instance of a patient presenting with bilateral lower limb weakness and unilateral vocal fold palsy, as a manifestation of vitamin B12 deficiency. Quick recognition and treatment resulted in a full recovery.Discussion:To our knowledge, this is the first reported case of unilateral vocal fold palsy secondary to vitamin B12 deficiency. Central and peripheral neuropathies have been described; however, other than the optic nerve, the cranial nerves are very rarely affected. It is important to consider vitamin B12 deficiency as a cause, as speedy identification and treatment can help prevent permanent neurological damage.
The design and implementation of a novel security model for HealthAgents
Authors: Xiao Liang , Dasmahapatra Srinandan , Lewis Paul , Hu Bo , Peet Andrew , Gibb Alex , Dupplaw David , Croitoru Madalina , Estanyol Francesc , Martínez-Miranda Juan , González-Vélez Horacio , Ariet Magílluch I 
Published: July 2011

AbstractIn this paper, we analyze the special security requirements for software support in health care and the HealthAgents system in particular. Our security solution consists of a link-anonymized data scheme, a secure data transportation service, a secure data sharing and collection service, and a more advanced access control mechanism. The novel security service architecture, as part of the integrated system architecture, provides a secure health-care infrastructure for HealthAgents and can be easily adapted for other health-care applications.
The HealthAgents ontology: knowledge representation in a distributed decision support system for brain tumours
Authors: Hu Bo , Croitoru Madalina , Roset Roman , Dupplaw David , Lurgi Miguel , Dasmahapatra Srinandan , Lewis Paul , Martínez-Miranda Juan , Sáez Carlos 
Published: July 2011

AbstractIn this paper we present our experience of representing the knowledge behind HealthAgents (HA), a distributed decision support system for brain tumour diagnosis. Our initial motivation came from the distributed nature of the information involved in the system and has been enriched by clinicians’ requirements and data access restrictions. We present in detail the steps we have taken towards building our ontology starting from knowledge acquisition to data access and reasoning. We motivate our representational choices and show our results using domain examples used by clinical partners in HA.
A Web-accessible distributed data warehouse for brain tumour diagnosis
Authors: Estanyol Francesc , Rafael Xavier , Roset Roman , Lurgi Miguel , Mier Mariola , Lluch-Ariet Magi 
Published: July 2011

AbstractCurrently, biological databases (DBs) are a common tool to complement the research of a wide range of biomedical disciplines, but there are only a few specialized medical DBs for human brain tumour magnetic resonance spectroscopy (MRS) data; they typically store a limited range of biological data (i.e. clinical information, magnetic resonance imaging and MRS data) and are not offered as open-source Structured Query Language relational DB schemas. We present a novel approach to biological DBs: a distributed Web-accessible DB for storing and managing clinical and biomedical data related to brain tumours from different clinical centres. This tool is designed for multi-platform systems with dissimilar DB management systems. Being the main data repository of the HealthAgents (HA) project, it uses multi-agent technology and allows the centres to share data and obtain diagnosis classifications from other centres distributed around the world in a reliable way.The HA project aims to create an agent-based distributed decision support system (DSS) to assist doctors to provide a brain tumour diagnosis and prognosis. The HA DB enables the DSS to totally integrate with its Graphical User Interface to perform classifications with the stored data and visualize the results using the HA distributed agents framework. This new feature converts the system presented in the first application in the world to combine a storage and management tool for brain tumour data and a complete Web-based DSS to obtain automatic diagnosis.
The development of a graphical user interface, functional elements and classifiers for the non-invasive characterization of childhood brain tumours using magnetic resonance spectroscopy
Authors: Gibb Alexander , Easton John , Davies Nigel , Sun YU , MacPherson Lesley , Natarajan Kal , Arvanitis Theodoros , Peet Andrew 
Published: July 2011

AbstractMagnetic resonance spectroscopy (MRS) is a non-invasive method, which can provide diagnostic information on children with brain tumours. The technique has not been widely used in clinical practice, partly because of the difficulty of developing robust classifiers from small patient numbers and the challenge of providing decision support systems (DSSs) acceptable to clinicians. This paper describes a participatory design approach in the development of an interactive clinical user interface, as part of a distributed DSS for the diagnosis and prognosis of brain tumours. In particular, we consider the clinical need and context of developing interactive elements for an interface that facilitates the classification of childhood brain tumours, for diagnostic purposes, as part of the HealthAgents European Union project. Previous MRS-based DSS tools have required little input from the clinician user and a raw spectrum is essentially processed to provide a diagnosis sometimes with an estimate of error. In childhood brain tumour diagnosis where there are small numbers of cases and a large number of potential diagnoses, this approach becomes intractable. The involvement of clinicians directly in the designing of the DSS for brain tumour diagnosis from MRS led to an alternative approach with the creation of a flexible DSS that, allows the clinician to input prior information to create the most relevant differential diagnosis for the DSS. This approach mirrors that which is currently taken by clinicians and removes many sources of potential error. The validity of this strategy was confirmed for a small cohort of children with cerebellar tumours by combining two diagnostic types, pilocytic astrocytomas (11 cases) and ependymomas (four cases) into a class of glial tumours which then had similar numbers to the other diagnostic type, medulloblastomas (18 cases). Principal component analysis followed by linear discriminant analysis on magnetic resonance spectral data gave a classification accuracy of 91% for a three-class classifier and 94% for a two-class classifier using a leave-one-out analysis. This DSS provides a flexible method for the clinician to use MRS for brain tumour diagnosis in children.
Cyclospora cayetanensis: a description of clinical aspects of an outbreak in Quebec, Canada
Authors: MILORD F. , LAMPRON-GOULET E. , ST-AMOUR M. , LEVAC E. , RAMSAY D. 
Published: July 2011

SUMMARYCyclospora cayetanensis is an emerging infectious agent. The aim of this study was to describe an outbreak that occurred in 250 adults exposed to contaminated food, focusing on the duration and relapses of symptoms, complications and evidence of local transmission. This outbreak affected workers who ate in a restaurant in June 2005. Cyclospora sp. was observed in the stools of 20 cases and 122 probable cases were identified. The attack rate was estimated at 89%. Main symptoms were diarrhoea (96%), nausea (88%), fatigue (87%), abdominal cramps (85%), fever (52%) and headaches (45%). Contaminated fresh basil originating from a Mexican farm, used to prepare an uncooked appetizer, was identified as the source. In this non-endemic population of immunocompetent adults, Cyclospora infection presents with watery diarrhoea lasting from 4 to 18 days and fatigue lasting from 11 to 42 days. For a small proportion of affected persons, recovery can be delayed.
Spatial distribution of microbial communities in the cystic fibrosis lung
Authors: Willner Dana , Haynes Matthew R , Furlan Mike , Schmieder Robert , Lim Yan Wei , Rainey Paul B , Rohwer Forest , Conrad Douglas 
Published: July 2011

Abstract
Cystic fibrosis (CF) is a common fatal genetic disorder with mortality most often resulting from microbial infections of the lungs. Culture-independent studies of CF-associated microbial communities have indicated that microbial diversity in the CF airways is much higher than suggested by culturing alone. However, these studies have relied on indirect methods to sample the CF lung such as expectorated sputum and bronchoalveolar lavage (BAL). Here, we characterize the diversity of microbial communities in tissue sections from anatomically distinct regions of the CF lung using barcoded 16S amplicon pyrosequencing. Microbial communities differed significantly between different areas of the lungs, and few taxa were common to microbial communities in all anatomical regions surveyed. Our results indicate that CF lung infections are not only polymicrobial, but also spatially heterogeneous suggesting that treatment regimes tailored to dominant populations in sputum or BAL samples may be ineffective against infections in some areas of the lung.
Hydrocarbon monooxygenase in Mycobacterium: recombinant expression of a member of the ammonia monooxygenase superfamily
Authors: Coleman Nicholas V , Le Nga B , Ly Mai A , Ogawa Hitoha E , McCarl Victoria , Wilson Neil L , Holmes Andrew J 
Published: July 2011

Abstract
The copper membrane monooxygenases (CuMMOs) are an important group of enzymes in environmental science and biotechnology. Areas of relevance include the development of green chemistry for sustainable exploitation of methane (CH4) reserves, remediation of chlorinated hydrocarbon contamination and monitoring human impact in the biogeochemical cycles of CH4 and nitrogen. Challenges for all these applications are that many aspects of the ecology, physiology and structure–function relationships in the CuMMOs are inadequately understood. Here, we describe genetic and physiological characterization of a novel member of the CuMMO family that has an unusual physiological substrate range (C2–C4 alkanes) and a distinctive bacterial host (Mycobacterium). The Mycobacterial CuMMO genes (designated hmoCAB) were amenable to heterologous expression in M. smegmatis—this is the first example of recombinant expression of a complete and highly active CuMMO enzyme. The apparent specific activity of recombinant cells containing hmoCAB ranged from 2 to 3 nmol min–1 per mg protein on ethane, propane and butane as substrates, and the recombinants could also attack ethene, cis-dichloroethene and 1,2-dichloroethane. No detectable activity of recombinants or wild-type strains was seen with methane. The specific inhibitor allylthiourea strongly inhibited growth of wild-type cells on C2–C4 alkanes, and omission of copper from the medium had a similar effect, confirming the physiological role of the CuMMO for growth on alkanes. The hydrocarbon monooxygenase provides a new model for studying this important enzyme family, and the recombinant expression system will enable biochemical and molecular biological experiments (for example, site-directed mutagenesis) that were previously not possible.
The phylogenetic composition and structure of soil microbial communities shifts in response to elevated carbon dioxide
Authors: He Zhili , Piceno Yvette , Deng Ye , Xu Meiying , Lu Zhenmei , DeSantis Todd , Andersen Gary , Hobbie Sarah E , Reich Peter B , Zhou Jizhong 
Published: July 2011

Abstract
One of the major factors associated with global change is the ever-increasing concentration of atmospheric CO2. Although the stimulating effects of elevated CO2 (eCO2) on plant growth and primary productivity have been established, its impacts on the diversity and function of soil microbial communities are poorly understood. In this study, phylogenetic microarrays (PhyloChip) were used to comprehensively survey the richness, composition and structure of soil microbial communities in a grassland experiment subjected to two CO2 conditions (ambient, 368 p.p.m., versus elevated, 560 p.p.m.) for 10 years. The richness based on the detected number of operational taxonomic units (OTUs) significantly decreased under eCO2. PhyloChip detected 2269 OTUs derived from 45 phyla (including two from Archaea), 55 classes, 99 orders, 164 families and 190 subfamilies. Also, the signal intensity of five phyla (Crenarchaeota, Chloroflexi, OP10, OP9/JS1, Verrucomicrobia) significantly decreased at eCO2, and such significant effects of eCO2 on microbial composition were also observed at the class or lower taxonomic levels for most abundant phyla, such as Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes and Acidobacteria, suggesting a shift in microbial community composition at eCO2. Additionally, statistical analyses showed that the overall taxonomic structure of soil microbial communities was altered at eCO2. Mantel tests indicated that such changes in species richness, composition and structure of soil microbial communities were closely correlated with soil and plant properties. This study provides insights into our understanding of shifts in the richness, composition and structure of soil microbial communities under eCO2 and environmental factors shaping the microbial community structure.