bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiomics for differentiating radiation-induced brain injury from recurrence in gliomas: systematic review, meta-analysis, and methodological quality evaluation using METRICS and RQS
Authors: Kocak Burak , Mese Ismail , Ates Kus Ece 
Published: February 2025

Abstract

Objective
To systematically evaluate glioma radiomics literature on differentiating between radiation-induced brain injury and tumor recurrence.

Methods
Literature was searched on PubMed and Web of Science (end date: May 7, 2024). Quality of eligible papers was assessed using METhodological RadiomICs Score (METRICS) and Radiomics Quality Score (RQS). Reliability of quality scoring tools were analyzed. Meta-analysis, meta-regression, and subgroup analysis were performed.

Results
Twenty-seven papers were included in the qualitative assessment. Mean average METRICS score and RQS percentage score across three readers was 57% (SD, 14%) and 16% (SD, 12%), respectively. Score-wise inter-rater agreement for METRICS ranged from poor to excellent, while RQS demonstrated moderate to excellent agreement. Item-wise agreement was moderate for both tools. Meta-analysis of 11 eligible studies yielded an estimated area under the receiver operating characteristic curve of 0.832 (95% CI, 0.757–0.908), with significant heterogeneity (I
2 = 91%) and no statistical publication bias (p = 0.051). Meta-regression did not identify potential sources of heterogeneity. Subgroup analysis revealed high heterogeneity across all subgroups, with the lowest I
2 at 68% in studies with proper validation and higher quality scores. Statistical publication bias was generally not significant, except in the subgroup with the lowest heterogeneity (p = 0.044). However, most studies in both qualitative analysis (26/27; 96%) and primary meta-analysis (10/11; 91%) reported positive effects of radiomics, indicating high non-statistical publication bias.

Conclusion
While a good performance was noted for radiomics, results should be interpreted cautiously due to heterogeneity, publication bias, and quality issues thoroughly examined in this study.

Key Points

Question

Radiomic literature on distinguishing radiation-induced brain injury from glioma recurrence lacks systematic reviews and meta-analyses that assess methodological quality using radiomics-specific tools.

Findings

While the results are encouraging, there was substantial heterogeneity, publication bias toward positive findings, and notable concerns regarding methodological quality.

Clinical relevance

Meta-analysis results need cautious interpretation due to significant problems detected during the analysis (e.g., suboptimal quality, heterogeneity, bias), which may help explain why radiomics has not yet been translated into clinical practice.

Graphical Abstract
Potential of photon-counting detector CT technology for contrast medium reduction in portal venous phase thoracoabdominal CT
Authors: Popp Daniel , Siedlecki Martin , Friedrich Lena , Haerting Mark , Scheurig-Muenkler Christian , Schwarz Florian , Kroencke Thomas , Bette Stefanie , Decker Josua A. 
Published: February 2025

Abstract

Objectives
To compare image quality and iodine attenuation intra-individually in portal venous phase photon-counting detector CT (PCD-CT) scans using protocols with different contrast medium (CM) volume.

Materials and methods
A prospectively acquired patient cohort between 04/2021 and 11/2023 was retrospectively screened if patients had the following combination of portal venous phase thoracoabdominal CT scans: (a) PCD-CT with 120 mL CM volume (PCD-CT120 mL), (b) PCD-CT with 100 mL CM volume (PCD-CT100 mL), and (c) prior energy-integrating detector CT (EID-CT) with 120 mL CM volume. On PCD-CT, virtual monoenergetic image (VMI) reconstructions at 70 keV were applied for both groups as well as additional VMI at 60 keV for PCD‑CT100 mL. Quantitative analyses including signal-to-noise (SNR) and contrast-to-noise ratios (CNR) and qualitative analyses were performed using a mixed linear effects model.

Results
The final study cohort comprised 49 patients (mean age 67 [31–86] years, 12 female). Comparison to EID-CT was available in 33 patients. In standard 70 keV VMI reconstructions, PCD-CT100 mL was non-inferior to PCD-CT120 mL as well as to EID-CT120 mL for CNR in abdominal organs (all p > 0.050). The mixed linear effects model revealed significant differences between contrast volume groups for both contrast enhancement and image quality ratings. PCD-CT100 mL/70 keV demonstrated the smallest deviation from optimal contrast enhancement (−0.306, p < 0.001).

Conclusion
In portal venous phase thoracoabdominal PCD-CT, a nearly 17% reduction in CM was achievable while maintaining subjective and objective image quality compared to prior higher CM volume PCD-CT scans within the same patients and still surpassing image quality of previous exams on an EID-CT system.

Key Points

Question

How do image quality and iodine attenuation intra-individually compare in portal venous phase photon-counting detector CT (PCD-CT) scans using protocols with different contrast medium volume.

Findings

PCD-CT scans exhibit superior quantitative and qualitative image quality compared to energy-integrating detector-CT acquisitions and are not negatively affected by contrast volume reductions up to 17%.

Clinical relevance

This study provides further evidence that PCD-CT enables a considerable reduction in iodine dose for portal venous phase acquisition, benefiting both patients and healthcare system costs.
Comparison of volumetric and linear measurements of intestinal inflammation and treatment response in children with newly diagnosed ileal Crohn disease
Authors: Derinkuyu Betul E. , Bard Andrew , Naim Iyad , Tkach Jean A. , Denson Lee A. , Dillman Jonathan R. 
Published: February 2025

Abstract

Objectives
To compare the responsiveness of linear and volumetric assessments of intestinal inflammation in children with newly diagnosed ileal Crohn disease (CD) into treatment.

Materials and methods
Twenty children with ileal CD (8 girls; mean age = 14.0 years) between May 2019 and April 2021 underwent research MRI at three time points—diagnosis, 6 weeks, and 6 months into treatment. For each examination, a radiologist measured the maximum wall thickness and length of disease. Then, the inflamed ileum was manually and semi-automatically segmented to measure the tissue volume. Mixed-effects models were used to assess the changes over time. Intra-class correlation was used to assess agreement between manual and semi-automated segmentation.

Results
Length of disease decreased with medical treatment (19.2 vs. 12.2 vs. 8.0 cm; p = 0.002), 36% from baseline to 6 weeks and 58% from baseline to 6 months, while maximum bowel wall thickness also decreased over time (7.6 vs. 5.8 vs. 4.5 mm; p < 0.0001), 24% from baseline to 6 weeks and 41% from baseline to 6 months. Manual volumetric measurements demonstrated a significant treatment response (19.8 vs.11.6 vs.5.1 mL; p < 0.0001), 41% decrease from baseline to 6 weeks and 74% from baseline to 6 months. Using semi-automated segmentation, the volume decreased significantly over time as well (24.0 vs.15.1 vs.9.1 mL; p = 0.0007), 37% from baseline to 6 weeks and 62% from baseline to 6 months. There was good agreement between manual and semi-automated volumetric assessments (ICC = 0.78 [95% CI: 0.57–0.88]).

Conclusion
Volumetric measurement of inflammation is responsive to medical treatment in CD and, as percentage compared to baseline, may show greater treatment response than linear measurements.

Key Points

Question

Volumetric measurements of intestinal inflammation related to Crohn disease may be superior to traditional linear measurements.

Findings

Volumetric measurements showed greater treatment response when compared to linear measurements, and there was good agreement between manual and semi-automated volumetric measurements of intestinal inflammation.

Clinical relevance

Volumetric assessment is a promising tool that may provide a novel biomarker for evaluating intestinal inflammation and treatment response in Crohn Disease.
Analysis of laser-induced damage threshold of circular grating waveguide structures exposed to sub-picosecond laser radiation centered at a wavelength of 1030 nm
Authors: Didychenko Denys , Li Fangfang , Savchenko Anton , Zideluns Janis , Stehlik Marek , Gallais Laurent , Lumeau Julien , Lemarchand Fabien , Karvinen Petri , Kuittinen Markku , Pruss Christof , Jamon Damien , Graf Thomas , Abdou Ahmed Marwan 
Published: February 2025

Abstract
The laser-induced damage threshold of a grating waveguide output coupler (GWOC) exposed to laser radiation at a wavelength of 1030 nm and with a pulse duration of 500 fs was investigated. The GWOC is a combination of a sub-wavelength circular grating and a partial reflector based on a Nb2O5 and SiO2 multilayer sequence. It was designed to be used as an output coupler of a thin-disk laser cavity for the generation of beams with radial polarization. The results revealed a laser-induced damage threshold (LIDT) fluence of 0.36 J/cm² for single-pulse tests and 0.26 J/cm² for multiple-pulse conditions with up to 1000 shots. These threshold values are comparable to those of an unstructured output coupler with Nb2O5 and SiO2 coating layers, highlighting the minor influence of the grating on the LIDT.
Observing Solid–Solid Phase Transitions in Two Alkanes and Natural Wax with Multidimensional NMR Relaxometry
Authors: Nelson Madison L. , Thrane Linn W. , Codd Sarah L. , Cape Jonathan L. , Craig Christopher D. , Pluntze Amanda , Seymour Joseph D. 
Published: February 2025

Abstract
Nuclear magnetic resonance (NMR) spin–spin T
2 relaxation is applied to characterize structural rearrangements in solid–solid phase transitions of lipids. 1D T
2 relaxation distributions as a function of temperature indicate solid–solid transitions not easily discernible by differential scanning calorimetry (DSC). T
2–T
2 correlation exchange measurements are demonstrated to be sensitive to spin-diffusion, allowing measurement of morphological length scales related to solid–solid molecular structure rearrangement by NMR relaxometry. T
2 dispersion distributions indicate radio frequency pulse separation time dependence which alters with morphology and temperature. The NMR relaxometry data are complementary to DSC and has potential for bench top low field NMR implementation.
An interpretable approach to detect case law on housing and eviction issues within the HUDOC database
Authors: Mohammadi Mohammad , Wieling Martijn , Vols Michel 
Published: February 2025

Abstract
Case law plays a critical role in shaping our understanding of human rights, including the right to adequate housing. However, analyzing large legal databases like HUDOC, which contains over 40,000 cases, is a challenging task that requires automated solutions. This study focuses on detecting cases related to housing—a topic encompassing issues such as eviction, access to adequate housing and etc.—from the HUDOC database. For this, we developed classifiers to identify cases related to both housing and eviction issues. We first constructed a dataset using an unsupervised process refined through manual corrections. Then, we trained the Adaptive Chordal Distance-based Subspace Learning Vector Quantization models. These models achieved classification accuracies of 93% for housing-related cases and 91.5% for eviction-specific cases, matching the performance of transformer-based models while requiring fewer computational resources. Furthermore, they provide interpretability by assigning word-level importance scores, helping legal scholars understand and verify the reasoning behind the model’s predictions. The models identified 2,305 potentially housing-related cases. Manual reviews confirmed that 278 of 340 reviewed cases were indeed relevant. By detecting overlooked cases and enriching legal datasets, this study highlights the utility of NLP methods in facilitating the analysis of human rights case law. This approach supports a deeper exploration of housing rights and eviction-related decisions under the European Court of Human Rights (ECtHR), offering transparency, efficiency, and scalability for legal research.
Prevalence of cannabis and medication use by indices of residential urbanicity and deprivation among Ohio cancer patients
Authors: Brasky Theodore M. , Lee Shieun , McBride Bella , Newton Alison M. , Baltic Ryan D. , Wagener Theodore L. , Conroy Sara , Hays John L. , Stevens Erin E. , Adib Anita , Krok-Schoen Jessica L. 
Published: February 2025

Abstract

Purpose
There is increasing interest in the use of cannabis products to alleviate symptom burden among cancer patients. Although data remain limited, some evidence suggests that state legalization of cannabis is associated with reduced opioid use. Indices of area-level social determinants of health may provide insights into the patterns of symptom-managing behaviors in the context of health equity.

Methods
Residential ZIP codes from 854 Ohio residents diagnosed with invasive cancer at an academic cancer center were used to assign rural–urban commuting area (RUCA) codes and social deprivation index (SDI) values. RUCA was categorized as metropolitan and non-metropolitan, and SDI was dichotomized at the median. Participants completed a one-time cannabis-focused questionnaire which included items on medications used to alleviate symptoms.

Results
The prevalence of self-reported cannabis (19% vs. 13%) and opioid use (30% vs. 21%) were higher among patients living in areas of higher social disadvantage vs. lower. No differences were observed for use of benzodiazepines or for any product by residential urbanicity.

Conclusion
Larger, multi-institutional studies with detailed measurement of cannabis and medications and an increased capacity to examine additional social determinants of health are needed to confirm and explain these descriptive findings.
Monotonicity, Bounds and Acceleration of Block Gauss and Gauss–Radau Quadrature for Computing $$B^T \phi (A) B$$
Authors: Zimmerling Jörn , Druskin Vladimir , Simoncini Valeria 
Published: February 2025

Abstract
In this paper, we explore quadratures for the evaluation of

$$B^T \phi (A) B$$

B
T

ϕ

(
A
)

B

where A is a symmetric positive-definite (s.p.d.) matrix in

$$\mathbb {R}^{n \times n}$$

R

n
×
n

, B is a tall matrix in

$$\mathbb {R}^{n \times p}$$

R

n
×
p

, and

$$\phi (\cdot )$$

ϕ
(
·
)

represents a matrix function that is regular enough in the neighborhood of A’s spectrum, e.g., a Stieltjes or exponential function. These formulations, for example, commonly arise in the computation of multiple-input multiple-output (MIMO) transfer functions for diffusion PDEs. We propose an approximation scheme for

$$B^T \phi (A) B$$

B
T

ϕ

(
A
)

B

leveraging the block Lanczos algorithm and its equivalent representation through Stieltjes matrix continued fractions. We extend the notion of Gauss–Radau quadrature to the block case, facilitating the derivation of easily computable error bounds. For problems stemming from the discretization of self-adjoint operators with a continuous spectrum, we obtain sharp estimates grounded in potential theory for Padé approximations and justify averaging algorithms at no added computational cost. The obtained results are illustrated on large-scale examples of 2D diffusion and 3D Maxwell’s equations and a graph from the SNAP repository. We also present promising experimental results on convergence acceleration via random enrichment of the initial block B.
California Pharmacists’ Perspectives and Experiences with Prayer and Spiritual Conversations with Patients: An Exploratory Study
Authors: Gavaza Paul , Kyrillos Soryal , Rawal Bhaktidevi , Taylor Elizabeth Johnston 
Published: February 2025

Abstract
This exploratory study examined the spiritual care beliefs of California pharmacists and their perspectives and experiences with prayer and spiritual conversations with patients. An online survey was utilized to collect data from members of the California Society of Health-System Pharmacists in Spring 2021. Most of the 85 respondents (3.4% response rate) were Christian (61%), spiritual (73%) and had a spiritual or religious conversation with a patient (60%) and many had prayed for a patient (48%). Respondents believed that pharmacists can initiate prayer (32%) and spiritual conversations (45%) with a patient.
Microwave-assisted synthesis of MgH2 nanoparticles for hydrogen storage applications
Authors: Ocampo Robinson Aguirre , Arias-Velandia Julian , Lenis Julian A. , Gil Alejandro A. Zuleta , Bello Sindy , Correa Esteban , Arrieta Carlos , Bolívar Francisco J. , Echeverria Echeverria Félix 
Published: February 2025

Abstract
Magnesium’s high storage capacity, with a theoretical value of about 7.6 wt.%, makes it a viable candidate for hydrogen storage. However, slow kinetics and strong thermodynamic stability lead to a rather high desorption temperature, usually above 350 °C. It has been demonstrated that nanosizing magnesium-based materials is a successful strategy for simultaneously improving the kinetic and thermodynamic characteristics of MgH2 during hydrogen absorption and desorption. MgH2 nanoparticles were obtained by microwave assisted synthesis. To the best of our knowledge, synthesis of MgH2 nanoparticles by this method has not been reported. It was possible to produce MgH2 nanoparticles smaller than 20 nm. MgO and Mg(OH)2 were also present in the produced nanoparticles, although these compounds may enhance the processes involved in the release and absorption of hydrogen.
Holomorphic projection for sesquiharmonic Maass forms
Authors: Allen Michael , Beckwith Olivia , Sharma Vaishavi 
Published: February 2025

Abstract
We study the holomorphic projection of mixed mock modular forms involving sesquiharmonic Maass forms. As a special case, we numerically express the holomorphic projection of a function involving real quadratic class numbers multiplied by a certain theta function in terms of eta quotients. We also analyze certain shifted convolution L-series involving mock modular forms and bound certain shifted convolution sums.
Growth hormone-releasing hormone receptor (GHRH-R) and its signaling
Authors: Halmos Gabor , Szabo Zsuzsanna , Dobos Nikoletta , Juhasz Eva , Schally Andrew V. 
Published: February 2025

Abstract
The hypothalamic polypeptide growth hormone-releasing hormone (GHRH) stimulates the secretion of growth hormone (GH) from the pituitary through binding and activation of the pituitary type of GHRH receptor (GHRH-R), which belongs to the family of G protein-coupled receptors with seven potential membrane-spanning domains. Various splice variants of GHRH-R (SV) in human neoplasms and other extrapituitary tissues were demonstrated and their cDNA was sequenced. Among the SVs, splice variant 1 (SV1) possesses the greatest similarity to the full-length GHRH-R and remains functional by eliciting cAMP signaling and mitogenic activity upon stimulation by GHRH. In this review, we briefly discuss the activation, regulation, molecular mechanisms and signaling pathways of GHRH-Rs and their SVs in various tissues and also summarize the expression, biological activities and potential function of GHRH, its analogs and their receptors. A large body of work have extensively studied and evaluated potential clinical applications of agonists and antagonists of GHRH in diverse fields, including oncology, endocrinology, obesity, diabetes, other metabolic dysfunctions, cardiology, immune functions, mood disorders, Alzheimer’s and lung disease, ophthalmology, inflammation, wound healing and other applications. These results strongly support the potential therapeutic use of GHRH analogs in human medicine in the near future.
Exploring trajectories in supply chain integration: a systematic analysis of emerging themes
Authors: Kieu Manh-Kha , Nayak Rajkishore , Akbari Mohammadreza , George Majo , Panwar Tarun 
Published: February 2025

Abstract
The purpose of this research is to holistically examine the development of supply chain integration (SCI) domain over the preceding economic cycle to project emerging themes that will shape the trajectory of future research. We conduct a systematic literature review to explore the trajectories in SCI domain with articles retrieved from aggregating databases. A total of 152 articles, which satisfied the evaluation and selection process, were analysed. The analysis reveals the intricate correlation between SCI and performance and highlights the progressively pivotal role of blockchain, artificial intelligence, and environmental exigency in SCI adoption. Our findings suggest the need for further research into the impact of SCI on corporate social responsibility performance and on SCI adoption practice in specific industries. Tiered sample collection research is encouraged in this field. However, this paper only included high–ranking peer-reviewed publications. Future SLR papers can incorporate wider sources of data to include meaningful information. By identifying and elucidating key themes, this study offers valuable insights that can inform and guide future research directions in the field of SCI.
Building a Low-Threshold Model for HCV Diagnosis and Treatment Among Formerly Incarcerated Patients in Alabama
Authors: Hayden Margaret , Kishore Sanjay , Bradford Davis , Dedona Mikaela , Hunter Meghan , Luck Mary Ellen , Pratt Ryan 
Published: February 2025

Abstract

Background
Millions of Americans remain infected with hepatitis C (HCV). Innovation in care delivery is required to achieve the goal of national elimination.

Aim
Develop a low-threshold HCV treatment program.

Setting
Free clinic with mobile unit providing transitional care to people leaving jails and prisons across Alabama.

Participants
Formerly incarcerated persons, many of whom are uninsured and live in rural areas.

Program Description
We utilized point-of-care diagnostics to condense the HCV screening and pre-treatment evaluation into a single encounter. Patient assistance programs were used to obtain medications for uninsured patients. Clinical support was provided through in-person and telehealth care.

Program Evaluation
From January 2023 to December 2024, 369 patients were screened for HCV; 104 (28.1%) were HCV antibody positive, and 71 (19.2%) were viremic. Of these patients, 70 completed pre-treatment diagnostics, 54 started treatment, 41 confirmed completion, 20 had SVR12 collected, with 19 achieving cure (94% cure rate). The median time from diagnosis to treatment initiation was 27 days.

Discussion
It is possible to both diagnose HCV and complete the entire pre-treatment evaluation in a single encounter and initiate treatment within 1 month, even for predominantly uninsured populations in rural areas.
Phase Equilibria in the V-Rich Region of the V-Si-B System at 1400 °C
Authors: Yang Weiguang , Hasemann Georg , Carrion Saldaña Mustafa , Gorr Bronislava , Schwaiger Ruth , Krüger Manja 
Published: February 2025

Abstract
The phase equilibria in the V-rich region of the V-Si-B system, including the V8SiB4 phase, have been experimentally investigated. Eleven alloys with key compositions were produced by arc-melting or levitation-melting. The samples were then annealed at 1400 °C for 100/200/300 h under high vacuum condition. The as-cast and heat-treated alloys were investigated by scanning electron microscopy, electron backscatter diffraction, energy-dispersive x-ray spectroscopy and x-ray diffraction. The isothermal section at 1400 °C of the V-rich V-Si-B system was determined and compared with the one at 1600 °C. The determined isothermal section can be applied to the design of V-Si-B alloys.