bluuebunny/crossref_metadata_2025_split huggingface dataset:
New Strategies for Intelligent Computing in Improving the Accuracy of Engineering Costs
Authors: Song Yunfei 
Published: April 2024

Abstract
Accurate construction cost calculation is crucial for assessing project viability and selecting design programs. This paper enhances calculation accuracy by first employing the Boruta algorithm to identify vital cost-influencing factors, which serve as the basis for an improved construction cost model. We introduce an enhanced Artificial Neural Network (ANN) model that integrates the AdaBoost algorithm and cost-sensitive methods to refine construction cost estimations. The efficacy of this model is demonstrated through its overall engineering cost error rate of 3.92%, with specific errors in single-side cost, labor, materials, and machinery usage at 3.51%, 7.09%, 3.36%, and 7.93%, respectively. These results meet established accuracy standards, showcasing the model’s potential to significantly improve construction cost management and control.
Research on the Evaluation Model of Ecological Restoration Benefits of Industrial Waste Land Based on DEA Algorithm
Authors: Gao Yongle , Yang Yongchong 
Published: April 2024

Abstract
The escalating spread of industrial wastelands has spotlighted the need for effective ecological restoration. This paper introduces an evaluation system for assessing the environmental restoration benefits of such wastelands, integrating the entropy weight and optimal assignment method for index quantification. Enhancements to decision-making elements and the incorporation of the fuzzy comprehensive evaluation method have culminated in developing a D-FCE model-based ecological restoration benefit assessment model. An empirical analysis on selected sites revealed notable increases in soil organic carbon content post-restoration—ranging from 1.73% to 2.98% in ERL areas, 1.69% to 2.45% in GL areas, and 1.25% to 2.08% in AL areas—demonstrating significant carbon sequestration. Additionally, a 38% rise in ecological benefits was observed, translating to an economic boon of 8563.2 yuan/year. This study furnishes a scientific method for evaluating industrial wasteland restoration and underpins the formulation of pertinent policies.
The link between dietary nutrients intake and cardiovascular diseases in cold regions
Authors: Feng Rennan , Hong Qianqi , Cao Jingjing , Li Jian , Deng Lanxin , Wang Jing , Zhao Yang , Wang Cheng 
Published: April 2024

Abstract

Background
The cold winter weather in northern China influences the dietary habits of its residents, contributing to a heightened risk of cardiovascular disorders, such as hypertension and coronary heart disease. Key factors include low vegetable consumption and high salt and fat intakes. This study aims to investigate the relationships between northern dietary nutrient intake in northern China and cardiovascular disorders during the winter season.

Methods
A food frequency questionnaire tailored to the actual eating habits in northern China was designed. Retrospective data from 955 Chinese adults were collected from November to March between 2014 to 2023. Logistic regression was employed to analyze the relationship between dietary nutrients and cardiovascular diseases, with model performance assessed using receiver operating characteristic (ROC) curves.

Results
Adjusted for gender, age, and body mass index (BMI), an inverse association was observed between vitamin A (OR = 0.706, 95% CI: 0.550, 0.907), nicotinic acid (OR = 0.584, 95% CI: 0.447, 0.762), phosphorus (OR = 0.777, 95% CI: 0.608, 0.994), selenium (OR = 0.719, 95% CI: 0.560, 0.923), zinc (OR = 0.683, 95% CI: 0.531, 0.880), methionine (OR = 0.730, 95% CI: 0.569, 0.936), arginine (OR = 0.753, 95% CI: 0.588, 0.964), lysine (OR = 0.706, 95% CI: 0.550, 0.907), aspartic acid (OR = 0.730, 95% CI: 0.569, 0.936) and hypertension. Additionally, a negative association was found between niacin (OR = 0.752, 95% CI: 0.597, 0.946) and coronary heart disease. Conversely, a positive association was identified between iodine and hypertension (OR = 1.305, 95% CI: 1.020, 1.669) and coronary heart disease (OR = 1.301, 95% CI: 1.037, 1.634).

Conclusion
Our study suggests that maintaining a balanced dietary intake of vitamin A, niacin, phosphorus, selenium, zinc, methionine, arginine, lysine, and aspartic acid can be beneficial in preventing hypertension. Adequate niacin intake is associated with a lower risk of coronary heart disease. However, excessive iodine intake may contribute to hypertension and coronary heart disease.
Peroxisome proliferator-activated receptors gama ameliorates liver fibrosis in non-alcoholic fatty liver disease by inhibiting TGF-β/Smad signaling activation
Authors: Zhang Qingwei , Zhao Wenjie , Sun Zeqi , Dong Xinxin , Zhu Liwei , Zhang Zhen , Chen Ximing , Hu Yingying , Du Menghan , Li Jiamin , Zhang Yong 
Published: April 2024

Abstract

Background
Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by a progressive decline in liver function, leading to disruptions in liver integrity and metabolic function, resulting in lipid deposition and excessive accumulation of extracellular matrix (ECM). The pathogenesis of NAFLD is complex and not yet fully understood, contributing to the absence of specific therapeutic strategies. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor pivotal in regulating lipid and glucose metabolism. However, the impacts of PPARγ on NAFLD remains insufficiently explored. Thus, this study aimed to investigate the role of PPARγ in NAFLD and its underlying molecular mechanisms.

Methods
Chemical detection kits were utilized to quantify collagen content, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) level variations. Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to assess alterations in extracellular matrix-related genes and inflammatory response genes in liver tissue and HepG2 cells, while western blotting was conducted to analyze the levels of both PPARγ and the TGF-β/Smad signaling pathway.

Results
Our findings unveiled significantly reduced PPARγ expression in a rat model of NAFLD, leading to subsequent activation of the TGF-β/Smad signaling pathway. Furthermore, PPARγ activation effectively mitigated NAFLD progression by inhibiting inflammation and fibrosis-related gene expression and collagen production. On a cellular level, PPARγ activation was found to inhibit the expression of extracellular matrix-related genes such as matrix metalloproteinase 2 (MMP2) and matrix metalloproteinase 9 (MMP9), along with inflammatory response genes interleukin (IL)-1β and IL-6. Additionally, PPARγ activation led to a significant decrease in the levels of ALT and AST. At the molecular level, PPARγ notably down-regulated the TGF-β/Smad signaling pathway, which is known to promote liver fibrosis.

Conclusion
These groundbreaking findings underscore PPARγ activation as a promising therapeutic approach to delay NAFLD progression by targeting the TGF-β/Smad signaling pathway in hepatic cells. This highlights the potential of PPARγ as a promising therapeutic target for NAFLD management in clinical settings.
YBX1 inhibits mitochondrial-mediated apoptosis in ischemic heart through the PI3K/AKT signaling pathway
Authors: Bi Fangfang , Cao Miao , Wang Yuquan , Pan Qingming , Jing Zehong , Bing Danyang , Lyu Lifang , Yu Tong , Li Tianyu , Li Xuelian , Liang Haihai , Shan Hongli , Zhou Yuhong 
Published: April 2024

Abstract

Background
Myocardial infarction (MI) is associated with higher morbidity and mortality in the world, especially in cold weather. YBX1 is an RNA-binding protein that is required for pathological growth of cardiomyocyte by regulating cell growth and protein synthesis. But YBX1, as an individual RNA-binding protein, regulates cardiomyocytes through signaling cascades during myocardial infarction remain largely unexplored.

Methods
In vivo, the mouse MI model was induced by ligating the left anterior descending coronary artery (LAD), and randomly divided into sham operation group, MI group, MI+ YBX1 knockdown/overexpression group and MI+ negative control (NC) group. The protective effect of YBX1 was verified by echocardiography and triphenyltetrazolium chloride staining. In vitro, mitochondrial-dependent apoptosis was investigated by using CCK8, TUNEL staining, reactive oxygen species (ROS) staining and JC-1 staining in hypoxic neonatal mouse cardiomyocytes (NMCMs).

Results
YBX1 expression of cardiomyocytes was downregulated in a mouse model and a cellular model on the ischemic condition. Compared to mice induced by MI, YBX1 overexpression mediated by adeno-associated virus serotype 9 (AAV9) vector reduced the infarcted size and improved cardiac function. Knockdown of endogenous YBX1 by shRNA partially aggravated ischemia-induced cardiac dysfunction. In hypoxic cardiomyocytes, YBX1 overexpression decreased lactic dehydrogenase (LDH) release, increased cell viability, and inhibited apoptosis by affecting the expression of apoptosis related proteins, while knockdown of endogenous YBX1 by siRNA had the opposite effect. Overexpression of YBX1 restored mitochondrial dysfunction in hypoxic NMCMs by increasing mitochondrial membrane potential and ATP content and decreasing ROS. In hypoxic NMCMs, YBX1 overexpression increased the expression of phosphorylated phosphatidylinositol 3 kinase (PI3K)/AKT, and the antiapoptosis effect of YBX1 was eliminated t by LY294002, PI3K/AKT inhibitor.

Conclusion
YBX1 protected the heart from ischemic damage by inhibiting the mitochondrial-dependent apoptosis through PI3K/AKT pathway. It is anticipated that YBX1 may serve as a novel therapeutic target for MI.
Selected Aspects of Nutritional Habits of Polish Women in the Preconception Period and During Pregnancy
Authors: Niedbał Zuzanna , Zaborska Monika , Ogonowska Weronika , Jóźwiak Michał , Michalik-Marcinkowska Urszula 
Published: April 2024

Abstract

Background
The diet of women in the preconception period and during pregnancy has a crucial impact on the development of the fetus and the health and metabolism of the baby. The energy requirements of a pregnant woman are higher, in addition, she should ensure an appropriate intake of particular nutrients and fluids. Folic acid supplementation is the most effective intervention in reducing congenital neural coil defects, as is stopping the consumption of alcohol and minimizing the intake of caffeinated beverages.

Objectives
The aim of the study was to assess the dietary habits, including caffeine and alcohol consumption, of women who are pregnant or preparing to conceive a child.

Material and methods
The study population comprised (n=539) Polish women. An original questionnaire was used, including a metric and questions about preparation for pregnancy and dietary habits. Responses were collected via the Internet in forums for pregnant women.

Results
Of the total of the women surveyed, 73% said they were preparing for pregnancy. 64% of the respondents began taking folic acid supplements and 49% had started vitamin and mineral supplementation. Only 21% of women said they had changed their diet in preparation for conceiving offspring. As many as 34% of women said they themselves had adequate knowledge about nutrition during pregnancy, while 43% searched for information on this topic on the Internet. The factor that differentiated the practiced eating habits to the greatest extent was the level of education.

Conclusions
Despite numerous recommendations, there are still many women who do not prepare for pregnancy and do not follow preconception recommendations. A large number of Polish women with lower education still do not take folic acid. It is necessary to educate the society also about harmful effects of alcohol on the developing fetus. Knowledge should be spread with the use of social media, because women often look for information about nutritional rules on the Internet.
الترجيح بين النصوص المتعارضة عند الإمام عبد الله بن سالمٍ البصري المكي " ت 1134 هـ "في كتابه ضياء الساري في مسالك أبواب البخاري
Authors: عبيد السلطاني أحمد عباس , محمد السامرائي محمد محمود 
Published: April 2024

الحمد لله الذي بنعمته تتم الصّالحات، وبعد: فهذا البحث المعنون ب: ((الترجيح بين النصوص المتعارضة عند الإمام عبد الله بن سالمٍ البصريِّ ( ت 1134 هـ ) في كتابه ضياء الساري في مسالك أبواب البخاري)) يُراد بها دراسة على الكتاب حيث دأب فيه على تقرير أجوبة يندفع بها التعارض ، ويزول بها الإشكال ، دون ربطها بقواعد تضبطها ، فجاء هذا البحث مبينا لطريقة الترجيح بين النصوص المتعارضة ، وصياغتها على شكل قواعد في كلّ طريقة من طرق دفع التعارض الثلاثة: الجمع والنسخ والترجيح.
فتضمن البحث مبحثين: المبحث الأول تعريف التعارض وطرق دفع التعارض بين الأدلة الشرعية، وجاء المبحث الثاني للحديث عن منهج الإمام عبدالله بن سالم البصري في دفع التعارض بطريقة الترجيح التي استعملها رحمه الله، وعمله كخطوة أولى لرفع التعارض ، الجمع بينها ما أمكن، وهو بذلك يوافق الجمهور في تقديم الجمع ثم النسخ ثم الترجيح، ومن أوجه الترجيح التي استعملها العلامة البصري رحمه الله: أ- الترجيح باعتبار المتن. ب_ الترجيح المتعلقة باعتبار السند. ج - قواعد الترجيح باعتبار أمور خارجية، ،وصلّى الله على نبيا محمد وعلى آله وصحبه أجمعين.
نساء مبدعات اثناء البحث عن الذهب في كاليفورنيا 1848-1867.
Authors: محمود ادريس حردان , يوسف ضحى ثامر 
Published: April 2024

المرأة المهاجرة مبدعة صبورة هكذا وثق عنها التاريخ الامريكي منذ اول الهجرات نحو العالم الجديد ، فهي مبدعة اينما وجدت في حلها او ترحالها له لمسة من الابداع ، ملفتة للنظر طموحة تحب المال تبحث عن الشهرة ، قد تتمرد لكنها شرسة ، نعم من تلك الصفات كانت نساء كاليفورنيا اللواتي فضلن روح المغامرة لتغير حالهن الى الافضل ، لذلك ارتحلن الى غرب الولايات المتحدة الامريكية عبر الصحاري والبعض ركب البحر .
في حين كان الاعتقاد بضرورة عدم اشتراك النساء في تلك الرحلات اذ لم يكن قادرات على تحمل صعاب الطريق و أسلوب الحياة في مناجم الذهب لكن الامر ادى الى غير ذلك، اذ شاركت العديد من النساء ، وجدوا ان الرحلة شاقة ومليئة بالمصاعب من صعوبة الطقس ، لذا قامت النساء بأدوار غير تقليدية ودخلن مجال عمل الرجال للبقاء على قيد الحياة في مسير الرحلات إلى كاليفورنيا، وعندما وصلوهن إلى تجمعات الخيام في مناجم الذهب ، وجدوا ظروفًا بدائية للعيش بل ان المعيشة في تلك الاماكن كانت هي خارج مفردات الحياة الطبيعة التي اعتدوها غير أن المجتمع الحدودي الجديد الذي واجه النساء في كاليفورنيا حرّرهن أيضًا من الأدوار التقليدية ، اذ أجبرت العزلة المطلقة لمعسكرات التعدين والحفر الرجال والنساء على ابتكار ثقافتهم الخاصة ، وهي ثقافة مختلفة تمامًا عن ما كان متعارف عليه في الساحل الشرقي للولايات المتحدة الامريكية كانت كاليفورنيا مختلفة عن ذلك فعمال المناجم عدوانيين وغير مرتبطين بالقانون أو التقاليد أو الأسرة ، بل ان القانون الذي كان سائدا فيها هو ينطبق على قانون الصراع من اجل البقاء .
The Pragmatics of Bias in American Political Speeches
Authors: Al-Aadili Nesaem Mehdi , Mohammed Ashwaq Jasim 
Published: April 2024

This study deals with analyzing bias in selected American political speeches from a pragmatic perspective. The study aims at finding out the pragmatic strategies that American politicians exploit to issue bias in their political speeches. For the sake of clarification, this aim can be sub-divided into the following aims: (a) Specifying the speech acts that are utilized by American politician to issue bias, (b) Showing to what extent American politician exploit Grice’s maxims to realize bias, (c)Shedding light on the categories of presupposition that are available in the selected data, (d) Identifying the impoliteness strategies and sub- strategies that are used to issue bias in the political speeches uttered by an American politician, and (e) Specifying the tropes that are utilized to realize bias in the selected data. To achieve the aims of the study and test the validity of its hypotheses, the following procedures are adopted: three random speeches for an American politician have been selected to be analysed according to the adopted eclectic model to identify the types of bias and the pragmatic strategies utilized to issue bias in the selected data. At the end of the research, there are the major findings that the researchers arrived at.
Optimisation of exhaust emissions, vibration, and noise of unmodified diesel engine fuelled with canola biodiesel-diesel blends with natural gas addition by using response surface methodology
Authors: Özgür Ceyla , Uludamar Erinç , Soyhan Hakan Serhad , Raja Ahsan Shah Raja Mazuir 
Published: April 2024

The paper presents methods to determine the optimum input parameters of CNG addition, biodiesel blend ratio, and engine speed to improve engine responses in terms of exhaust emissions, vibration, and noise of CNG-biodiesel-diesel fuelled engines. Box–Behnken based on response surface methodology was used to predict and optimise input parameters. Variance analysis was applied to determine the significant relationship between the input parameters and engine responses. At optimum input parameters (CNG addition = 9.24 L/min, biodiesel blend ratio = 40%, engine speed = 1524.24 rpm), the optimum engine responses of NOx, CO, CO2, O2, engine vibration acceleration, and noise were 93.77 ppm, 438.05 ppm, 1.47%, 18.59%, 37.17 m/s2 and 91.34 dB[A], respectively. In terms of coefficient determination of R2, the values were 99.11%, 99.22%, 99.41%, 99.70%, 98.65%, and 98.60% respectively. The correlation between the optimised result and the engine test result showed an acceptable error limit for NOx, CO, CO2, O2, engine vibration acceleration, and noise as 4.2%, 3.8%, 4.9%, 0.25%, 4.12%, and 0.17%, respectively.
АНАЛИТИЧЕСКИЕ СВОЙСТВА РЕШЕНИЙ СЕМЕЙСТВА ТРЕХМЕРНЫХ ДИНАМИЧЕСКИХ ДИССИПАТИВНЫХ ПЯТИЭЛЕМЕНТНЫХ СИСТЕМ С ОДНОЙ КВАДРАТИЧНОЙ НЕЛИНЕЙНОСТЬЮ
Authors: Цегельник В. В. 
Published: April 2024

Объектом исследования является семейство трехмерных динамических пятиэлементных диссипативных систем с одной квадратичной нелинейностью, произвольным параметром A и параметром e, e2 = 1. В системах указанного семейства параметр A входит как множитель при линейном элементе (системы первого класса), или как отдельный элемент-константа (системы второго класса). Характерной особенностью (с качественной точки зрения) данного семейства является наличие в нем систем, обладающих хаотическим поведением, в частности обладающих странными аттракторами. Целью исследования является определение характера подвижных особых точек решений указанного семейства. Для анализа решений систем рассматриваемого семейства использован тест Пенлеве, а также сведение систем к эквивалентным им уравнениям второго или третьего порядков и сравнение последних с известными нелинейными уравнениями P-типа. Решения систем первого класса не обладают свойством Пенлеве (несмотря на то, что компоненты решений некоторых из них вообще не имеют подвижных особых точек), или не удовлетворяют тесту Пенлеве. Аналогично, решения систем второго класса либо не удовлетворяют тесту Пенлеве, либо не обладают свойством Пенлеве, несмотря на то, что компоненты решений некоторых систем вообще не имеют подвижных особых точек. Наличие систем с хаотическим поведением среди рассматриваемых систем позволяет указать автономные дифференциальные уравнения третьего порядка с хаотическим поведением.
Pathomorphological and immunohistochemical characteristics of the testicle in children with critical ischemia during acute torsion
Authors: Volos L.I. , Gorbatyuk O.M. , Veselyi M.Yu. , Veselyy S.V. , Lavrov D.V. 
Published: April 2024

Background. The occurrence of acute torsion of the testicle in children leads to ischemia of the testicle, and in the absence of timely medical assistance - to the loss of the organ. The period from 12 hours to 24 hours from the onset of the disease leaves only a 20% chance of saving the genital gonad. There are still no exact signs of viability of the affected gonad in case of critical ischemia of the testicle due to its torsion. Therefore, the study of the dynamics of changes in morphological structures in the course of acute testicular torsion, morphological and functional disorders resulting from torsion, is of great practical interest, because there is no consensus on the nature and degree of these changes in the affected gonad. Objective: study of the nature and severity of pathomorphological changes and immunohistochemical features of the acute torsion testicle in children within 12.1-24 hours or more from the onset of the disease. Methods. A histological, histochemical, and immunohistochemical study of testicular tissue biopsies taken during the operation of detorsion and orchiopexy, and orchidectomy within 12.1–24 hours or more from the onset of clinical symptoms of acute unilateral torsion in 16 patients was conducted. Results. The morphological study of the gonads showed that the duration of acute torsion of 12.1–24 hours or more is characterized by severe pathological changes found in the testicles. After 18 hours of acute ischemia, tubules were visualized in many fields of view in the form of shadows with the impossibility of identifying the structures due to hemorrhagic or ischemic infarcts. Immunohistochemical typing demonstrated the absence of expression of vimentin and calretinin, which indicated the death of sustentocytes (Sertoli cells) and Leydig cells. With a duration of acute torsion of 12.1-18 hours, a histochemical study of glycogen in the cytoplasm of spermatogonia, spermatocytes, and sustentocytes using the PAS-reaction showed that some cells of the spermatogenic epithelium were characterized by irreversible changes preceding necrosis, although giant multinucleated spermatids with relatively preserved glycogen, which meant there was a minimal chance for saving the gonad. Conclusion. Total duration of symptoms and degree of male gonadal torsion are the main prognostic factors for testicular preservation or necrosis in episodes of torsion. The duration of an acute torsion of 12.1-18 hours, according to morphological research, leaves in 42,9% of cases the presence of a minimal chance of saving the genital gonad. After 18 hours from the onset of acute complete testicular torsion in children, the operation of choice is orchidectomy.