bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV‐A Irradiation of 5‐Methoxypsoralen
Authors: Salvador Alessia , Dall'Acqua Stefano , Sardo Manlio Sutera , Caffieri Sergio , Vedaldi Daniela , Dall'Acqua Francesco , Borgatti Monica , Zuccato Cristina , Bianchi Nicoletta , Gambari Roberto 
Published: July 2010

AbstractInduction of terminal erythroid differentiation can be an efficient strategy to inhibit proliferation of chronic myelogenous leukemia cells. Psoralens, well‐known photo‐chemotherapeutic agents, were found to be efficient at inducing erythroid differentiation of K562 cells, an in vitro cell line isolated from the pleural effusion of a patient with chronic myelogenous leukemia in blast crisis. The effects of crude pre‐irradiated solutions of 5‐methoxypsoralen on erythroid differentiation of human leukemic K‐562 cells were evaluated. The major photoproduct was characterized and analyzed, and it was found to induce erythroid differentiation of K562 cells and inhibit NF‐κB/DNA interactions.
Evaluation of a breast cancer risk prediction model expanded to include category of prior benign breast disease lesion
Authors: Tamimi Rulla M. , Rosner Bernard , Colditz Graham A. 
Published: July 2010

AbstractBACKGROUND:Benign breast diseases (BBD) encompass several histologic subtypes with various risks of subsequent breast cancer. Information on previous benign breast disease biopsies has been incorporated into breast cancer risk prediction models; however, the type of histologic lesion has not been taken into account. Given the substantial heterogeneity in breast cancer risk dependent on the type of benign lesion, the authors evaluated whether incorporating this level of detail would improve the discriminatory power of risk classification models.METHODS:By using data from the Nurses' Health Study, a breast cancer nested case‐control study (240 cases; 1036 controls), the authors determined predictors of categories of BBD lesions and developed imputation models. The type of BBD, imputed for each cohort member who reported a diagnosis, was added to a modified version of the Rosner‐Colditz breast cancer risk prediction model.RESULTS:Compared with the model that included only previous BBD (yes/no), the model that included categories of BBD was significantly improved (P < .0001). Overall, including the category of BBD increased the concordance statistic from 0.628 to 0.635. By using risk reclassification, inclusion of the type of BBD resulted in a 17% increase in incidence per increase of 1 risk decile, holding the model without BBD type risk decile constant.CONCLUSIONS:Although the current data suggested that the inclusion of BBD category may improve breast cancer risk classification, the clinical utility of such a model will depend on the consistency of histologic classification of benign breast disease lesions. Cancer 2010. © 2010 American Cancer Society.
Two‐dimensional recursive digital filters with nearly circular‐symmetric magnitude response and approximately linear phase
Authors: Lee Ju‐Hong , Yang Yuan‐Hau 
Published: July 2010

AbstractThis paper presents a general structure using 1‐D and two‐dimensional (2‐D) recursive digital all‐pass filters (DAFs) for the design of 2‐D recursive circularly symmetric digital low‐pass filters (CS‐DLFs). The general structure is a cascade of two stages composed of all‐pass building blocks. The first stage is a parallel connection of a 2‐D recursive DAF with a symmetric half‐plane (SHP) support for its filter coefficients and a 2‐D pure delay block. The second stage composed of a parallel connection of a 1‐D recursive DAF and a 1‐D pure delay block is used for eliminating the unwanted pass‐band induced by the first stage. As a result, the design of a 2‐D CS‐DLF in either the least‐squares or the minimax sense can be formulated in a simple linear optimization problem in terms of the weighted‐phase response error for each DAF. Design results with nearly circularly symmetric magnitude response and approximately linear phase are also provided for illustration and comparison. Copyright © 2010 John Wiley & Sons, Ltd.
Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets by multivariate regression methods
Authors: Dinç Erdal , Üstündağ Özgür , Baleanu Dumitru 
Published: July 2010

AbstractThe sole use of pyridoxine hydrochloride during treatment of tuberculosis gives rise to pyridoxine deficiency. Therefore, a combination of pyridoxine hydrochloride and isoniazid is used in pharmaceutical dosage form in tuberculosis treatment to reduce this side effect. In this study, two chemometric methods, partial least squares (PLS) and principal component regression (PCR), were applied to the simultaneous determination of pyridoxine (PYR) and isoniazid (ISO) in their tablets. A concentration training set comprising binary mixtures of PYR and ISO consisting of 20 different combinations were randomly prepared in 0.1 M HCl. Both multivariate calibration models were constructed using the relationships between the concentration data set (concentration data matrix) and absorbance data matrix in the spectral region 200–330 nm. The accuracy and the precision of the proposed chemometric methods were validated by analyzing synthetic mixtures containing the investigated drugs. The recovery results obtained by applying PCR and PLS calibrations to the artificial mixtures were found between 100.0 and 100.7%. Satisfactory results obtained by applying the PLS and PCR methods to both artificial and commercial samples were obtained. The results obtained in this manuscript strongly encourage us to use them for the quality control and the routine analysis of the marketing tablets containing PYR and ISO drugs. Copyright © 2010 John Wiley & Sons, Ltd.
A rapid strategy to detect the recombined allele in LSL‐TβRICA transgenic mice
Authors: Vincent David F. , Kaniewski Bastien , Powers Shannon E. , Havenar‐Daughton Colin , Marie Julien C. , Wotton David , Bartholin Laurent 
Published: July 2010

AbstractWe have previously generated a transgenic mouse strain (LSL‐TβRICA) containing a Cre‐inducible constitutively active TGFβ type I receptor (Bartholin et al., 2008, Genesis 46: 724–731). Transgene expression depends on the excision of a floxed‐transcriptional STOP (LSL, Lox‐STOP‐Lox) located upstream the TβRICA coding sequence. To evaluate the correct excision of the STOP signal in the presence of Cre‐recombinase, we developed a rapid screening based on an original PCR genotyping strategy. More precisely, we designed a set of primers flanking the LSL containing region. The size of the amplified products will differ according to recombination status of the LSL‐TβRICA allele. Indeed, the size of the STOP containing PCR product is 1.93 kb, but is reduced to 0.35 kb when the STOP signal is removed after Cre‐mediated recombination. We validated excision in several compartments, including pancreas, liver, T lymphocytes, and embryos using different Cre expressing transgenic mouse strains. This represents a simple and efficient way of monitoring the tissue specific recombination of the LSL‐TβRICA allele. genesis 48:559–562, 2010. © 2010 Wiley‐Liss, Inc.
Effect of water absorption temperature on space charge profiles in paper/phenol‐resin composites for printed circuit boards
Authors: Echigo Yasutsune , Natsui Masashi , Maeno Takashi , Ohki Yoshimichi 
Published: July 2010

AbstractMore and more electronics are intended for use in adverse environments at high temperatures with high humidity. The spatial distributions of internal charge carriers, mainly due to ionic impurities that appear in hot and humid environments, are considered to affect the reliability of bulk insulation. Therefore, the authors examined space charge behavior inside paper/phenol‐resin composites for printed circuit boards under DC voltages, focusing on the effect of the water absorption temperature. Both the sample weight and thickness were increased monotonically by immersion in water with an increase in the water temperature from 24 to 85 , indicating that the water absorption by the sample was temperature dependent. In the early periods of water absorption (up to 10 hours), the electric field decreased near the two electrodes and increased in the other regions. Furthermore, heterocharge formation was observed near the cathode as the water absorption progressed, becoming more significant at higher water temperatures. Ion chromatography analyses detected numerous ions such as Na+, $NH_{4}^{+}$ and Cl‐ from the water, in which the sample had been immersed for 100 hours at various temperatures. It is highly possible that these ions are responsible for the heterocharge formation. 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(2): 1–7, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20992
Hydropower output forecast with tank models combined with Kalman filter estimation
Authors: Ofuji Kenta , Yamaguchi Nobuyuki , Hoshino Kazumi , Sakamoto Masaaki 
Published: July 2010

AbstractIn this paper, we study how to forecast the next‐day expected output of hydropower energy based on the past rainfall record in the reference area. The Tank Model, which has been conventionally applied to this type of forecast, has been improved by employing Kalman filter stepwise estimation in order to accommodate seasonal and yearly variations of rainfall water runoff conditions. Our Kalman Filter Tank Model (KF‐Tank Model) yielded a broader choice of parameters while maintaining an acceptable average forecast error level of about ±0.05 PU per forecast period. It is also shown that the error correction mechanism of the KF Tank Model can remain robust to snowfall and snowmelt seasons without requiring parameter revisions of the model. 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(2): 33–41, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20995
Research on magnetron phased array with mutual injection locking for space solar power satellite/station
Authors: Shinohara Naoki , Matsumoto Hiroshi 
Published: July 2010

AbstractThe SPS (Space Solar Power Satellite/Station) will be a clean base‐load power station in space. It will be the largest space system ever built and will require a high‐efficiency, large‐size, highly accurate, lightweight, inexpensive phased array in order to transmit energy generated in space to the ground. We have proposed and developed a phase‐controlled magnetron (PCM) with injection locking and PLL technique for the high‐efficiency, lightweight, inexpensive phased array. It still has several weak points: (1) approximately 10% power loss occurs at the circulator for injection locking, (2) phase shifter is needed in each PCM for the phased array. In order to correct the weak points, we propose a magnetron phased array with mutual injection locking. For the magnetron phased array, we only use two PCMs with phase shifters; the other components are self‐oscillated and mutual injection locked magnetrons. In this paper, we propose a new formula for use with the magnetron phased array with mutual injection locking. We also present the results of experiments on beam direction control with the magnetron phased array with mutual injection locking. 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(2): 21–32, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20998
A feasibility study of pressure‐retarded osmosis power generation system based on measuring permeation volume using reverse osmosis membrane
Authors: Enomoto Hiroshi , Fujitsuka Masashi , Hasegawa Tomoyasu , Kuwada Masatoshi , Tanioka Akihiko , Minagawa Mie 
Published: July 2010

AbstractA pressure‐retarded osmosis (PRO) power generation system is a hydroelectric power system which utilizes permeation flow through a semipermeable membrane. Permeation flow is generated by the potential energy of the salinity difference between sea water and fresh water. Since the cost of the membrane is high, the permeation performance of the membrane must be improved in order to realize PRO systems. We have investigated reverse osmosis (RO) membrane products as semipermeable membranes and measured the permeation volume of a few products. The generation power per unit membrane area calculated from the permeation volume is about 0.62 W/m2. But as a result of our improvements (greater salt water volume, spacers for fresh water channel with the function of discharging concentrated salinity, extralow‐pressure type of membrane, washing the support layer of membrane when the generation power falls by half) the generated power may be 2.43 W/m2. Then the power system cost would be about 4.1 million yen/kW. In addition, if the support layer of the membrane is made thinner and a PRO system is applied to equipment where pumping power for another purpose is available (wastewater treatment plants located at the seaside, thermal and nuclear power plants, sea water desalination plants), the generated power may be increased. These improvements may enable PRO systems to be realized at a cost close to that of photovoltaic power systems. 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(2): 8–20, 2010; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/eej.21000
Harmonic current suppression for PMSM by repetitive perfect tracking control
Authors: Nakai Takahiro , Fujimoto Hiroshi 
Published: July 2010

AbstractPM motor drives are widely used for high‐performance servo applications. However, the PM motor has an imperfect sinusoidal flux distribution which causes harmonic currents. Inverter dead time and current measurement error also lead to harmonic currents. The repetitive control method has been applied to current suppression. For repetitive control based on the internal model principle, the harmonic suppression characteristics are excellent. However, interharmonic components are amplified. The interharmonic components have frequencies that are nonintegral multiples of the fundamental frequency. Therefore, feedforward compensation is applied for the harmonic currents to improve the suppression characteristic. The authors propose harmonic current suppression control of a PM motor in αβ coordinates by using repetitive perfect tracking control with the PWM‐hold model. The advantages of the proposed method are shown by simulations and experiments. 2010 Wiley Periodicals, Inc. Electr Eng Jpn, 173(2): 55–63, 2010; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ eej.21009
Iodate Sensing Electrodes Based on Phosphotungstate‐ Doped‐Glutaraldehyde‐Cross‐Linked Poly‐L‐lysine Coatings
Authors: Thangamuthu R. , Pan Yu‐Ching , Chen Shen‐Ming 
Published: July 2010

AbstractGlassy carbon electrode modified with phosphotungstate‐doped‐glutaraldehyde‐cross‐linked poly‐L‐lysine (PLL‐GA‐PW) film was employed for iodate determination. The PLL‐GA‐PW film electrode shows excellent electrocatalytic activity towards iodate reduction with significant reduction of overpotential. Under optimized experimental conditions, a linear range from 5×10−8 to 2.27×10−2 M with a sensitivity of 61.75 μA mM−1 was obtained. Possible interfering species, in iodate determination, were evaluated and the applicability of proposed sensor for iodate estimation in table salt was also demonstrated. The PLL‐GA‐PW film electrode shows fast response, wider linear range, and good selectivity and stability.
Electrochemically Monitoring the Acid and Acidic Urea‐Induced Unfolding of Hemoglobin and Its Electrocatalytic Ability
Authors: Zhao Xiaojuan , Mai Zhibin , Dai Zong , Zou Xiaoyong 
Published: July 2010

AbstractAcid and acidic urea‐induced unfolding of hemoglobin (Hb) was investigated using protein‐film‐based electrochemical method. The conformational transition of Hb was monitored through the change of direct electrochemical response of Hb. The heme groups in Hb detached from their native binding sites after pH<4.0. Spectral experiments fully supported the results. Furthermore, the catalytic ability of Hb was enhanced 15 times under the optimal unfolded conditions of pH 2.0 PBS containing 3.0 mol L−1 urea. The method contributes to understand the relationship between function and conformation of Hb, and provides possibility of manipulating protein function by controlling its conformation.
Flow‐Injection Differential‐Pulse Anodic Stripping Voltammetry as a Tool for Thallium Monitoring in the Environment
Authors: Lukaszewski Zenon , Jakubowska Monika , Zembrzuski Wlodzimierz , Karbowska Bozena , Pasieczna Anna 
Published: July 2010

AbstractIn order to demonstrate the applicability of the Flow‐Injection Differential‐Pulse Anodic Stripping Voltammetry to monitoring of thallium in the environment, thallium concentration in water, bottom sediments and the soil of flood‐plain terraces of two rivulets were investigated. It is shown, that thallium containing particles are transported by rivulets and are deposited in bottom sediments (7.4 and 1.7 μg g−1downstream, respectively). Thallium originating from this source is dispersed in flood‐plain valley soil and is dissolved in rivulet water. Thallium concentration in water (0.32 and 0.21 μg L−1 downstream , respectively) exceeds the normal level by 20–30 times.
Thermal transformations of some monoterpene compounds in supercritical lower alcohols
Authors: Anikeev V. I. 
Published: July 2010

AbstractThis review systematizes the results of basic studies on thermal transformations of phytogenic terpene compounds (α‐ and β‐pinenes, turpentine, cis‐verbenol) performed in supercritical lower alcohols. The main result is the demonstration of a considerable increase in the rate of thermal isomerization of monoterpene compounds in supercritical lower alcohols, with the retained selectivity toward target products of the reaction as compared to the rate of similar reactions conducted in the gas or liquid phase. The kinetic studies provided a deep insight into the isomerization mechanism of these compounds and elucidated the role of supercritical solvent in a manifold increase of the reaction rate compared to isomerization of the same compounds in the gas or liquid phase. The pressure of a supercritical solvent was shown to strongly facilitate the acceleration of the reactions under study. Chemical transformations of the considered terpene compounds in supercritical fluid solvents can be used as a basis of modern highly efficient technologies for the production of a wide range of practically important organic compounds, medicinal and perfume substances. Copyright © 2010 John Wiley & Sons, Ltd.
Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor
Authors: Sasaki Masanori , Lankford Karen L. , Brown Robert J. , Ruddle Nancy H. , Kocsis Jeffery D. 
Published: July 2010

AbstractVarious models of experimental autoimmune encephalomyelitis (EAE) have led to insights into the pathogenesis and novel therapies for multiple sclerosis. One generalized EAE model uses immunizing the Lewis Rat with myelin oligodendrocyte glycoprotein (MOG) and complete Freund's adjuvant that induces systemic disease and inflammatory lesions at random central nervous system (CNS) locations. These lesions result from a combination of sensitized T cells and pathogenic antibodies gaining access to the CNS to cause an immune assault on myelin‐expressing oligodendrocytes. We report a focal and temporal variant of the EAE model that results in immune‐mediated demyelination at a predictable time and location. Lewis rats were immunized with the extracellular domain (1‐125) of recombinant rat MOG in incomplete Freund's adjuvant (IFA) to induce a clinically silent humoral response. Vascular endothelial growth factor (VEGF) was then microinjected into the spinal cord to induce a transient, focal breakdown of the blood brain barrier (BBB). Clinical signs were apparent within 72 hours and began to resolve by day 21. The histopathology at the site of injection consisted of a focal region containing OX‐42+ cells, phagocytic cells with debris, extensive demyelination, and some lymphocyte infiltration. Neither intraspinal injection of PBS into immunized animals nor VEGF into animals treated with IFA alone resulted in clinical lesions. Thus, a transient, focal opening of the BBB with VEGF in animals with subclinical MOG immunization leads to a discrete inflammatory demyelinating lesion. This model may be useful for the study of transplanted myelin‐forming cells in a discrete inflammatory demyelinating lesion. © 2010 Wiley‐Liss, Inc.
Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes
Authors: Jänen Sven B. , Chaachouay Hassan , Richter‐Landsberg Christiane 
Published: July 2010

AbstractA common pathway underlying a variety of neurodegenerative disorders is the aggregation and deposition of misfolded proteins. Proteasomal inhibition has been demonstrated to promote the formation of intracellular inclusions. We have shown before that astrocytes respond to the treatment with the proteasome inhibitor MG‐132 by aggresome formation and cytoskeletal disturbances, but unlike oligodendrocytes do not die by apoptotic cell death and have the capability to recover. This study was undertaken to elucidate if the autophagy‐lysosomal pathway participates in the efficient recovery process in astrocytes and is modulated under conditions of proteasomal inhibition. The data show that the autophagic pathway was stimulated during a 24‐h treatment with the proteasome inhibitor MG‐132 in a time and concentration‐dependent manner. It remained at an elevated level throughout a 24‐h recovery period in the absence of MG‐132 and participates in the aggregate clearing process. In the presence of the specific inhibitor of macroautophagy, 3‐methyladenine, cell viability was impaired, aggregates were not as efficiently removed and HSP25, αB‐crystallin and ubiquitinated proteins remained in the insoluble protein fraction. LC3‐II positive puncta, indicative of autophagosomes, were formed abundantly in the cells after proteasome inhibition and were seen in close association with the aggregates. Hence, the ability of astrocytes to upregulate autophagic degradation might contribute to their resistance against proteasomal stress situations and act as a compensatory mechanism when the proteasome is impaired. © 2010 Wiley‐Liss, Inc.