bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity
Authors: Clark Robert L. , Gristwood William E. , Lewsley Richard , Wilson Robert , Harrell Andrew W. 
Published: August 2010

AbstractBACKGROUND: The antimalarial drug artesunate affects erythroid cells leading to developmental toxicity and adult reticulocytopenia. We report on a kinetic study in rats and the tissue distribution of radioactivity following oral administration of [3H]‐artesunate to pregnant rats using quantitative whole‐body autoradiography (QWBA). METHODS: Rats were dosed orally with chlorproguanil/dapsone/artesunate (including 11.8 mg/kg artesunate) and plasma concentrations of artesunate and the active metabolite dihydroartemisinin (DHA) were determined. In the QWBA study, 6 rats received 13 mg/kg [3H]‐artesunate on day 18 of gestation. Groups of 2 rats were euthanized at 1, 6, and 24 hours after dosing, rapidly frozen, and sectioned in a cryostat. Sagittal sections were freeze‐dried and placed in contact with imaging plates. Tissue concentrations of radioactivity were quantified. RESULTS: Systemic exposure to DHA was up to 22‐fold higher than the parent compound and was higher in non‐pregnant females than males. In the QWBA study, high concentrations of radioactivity were seen in maternal tissues involved in absorption and excretion, the bone marrow and spleen. Fetal blood and liver levels were 3.8‐ to 8.8‐fold higher than maternal blood levels at all timepoints. CONCLUSIONS: Excluding tissues involved in absorption and excretion, the highest concentrations of radioactivity were observed in tissues involved in hemoglobin synthesis and/or destruction in both the mother and the fetus and likely account for the maternal reticulocytopenia and embryotoxicity. Radioactivity concentrations in the fetal blood were 2.1‐ to 2.8‐fold higher than maternal bone marrow at all timepoints and this difference could contribute to the lower dose threshold for embryotoxicity. Birth Defects Res (Part B) 89:364–375, 2010. © 2010 Wiley‐Liss, Inc.
Bacterial olfaction
Authors: Nijland Reindert , Burgess J. Grant 
Published: August 2010

AbstractSensing their environment is a crucial ability of all life forms. In higher eukaryotes the sensing of airborne volatile compounds, or olfaction, is well developed. In plants, slime moulds and yeast there is also compelling evidence that these organisms can smell their environment and respond accordingly. Here we show that bacteria are also capable of olfaction. Bacillus licheniformis was able to sense airborne volatile metabolites produced by neighbouring bacterial cultures and cells could respond to this chemical information in a coordinated way. When Bacillus licheniformis was grown in a microtitre plate adjacent to a bacterial culture of the same or a different species, growing in complex medium, biofilm formation and pigment production were elicited by volatile molecules. A weaker response occurred in increasingly distant wells. The emitted volatile molecule was identified as ammonia. These data demonstrate that B. licheniformis has evolved the ability collect information about its environment from the surrounding air and physiologically respond to it in a manner similar to olfaction. This is the first time that a behavioural response triggered by odorant molecules received through the gas phase is described in bacteria.
Detection and reduction of microaggregates in insulin preparations
Authors: Heldt Caryn L. , Sorci Mirco , Posada David , Hirsa Amir , Belfort Georges 
Published: August 2010

AbstractInsulin is an important biotherapeutic protein, and it is also a model protein used to study amyloid diseases, such as Alzheimer's and Parkinson's. The preparation of the protein can lead to small amounts of aggregate in the solution, which in turn may lead to irreproducible in vitro results. Using several pre‐treatment methods, we have determined that pH cycling and diafiltration of the insulin removes microaggregates that may be present in the solution. These microaggregates were not detectable with traditional biochemical methods, but using small‐angle neutron scattering, we were able to show that pH cycling reduces the radius of gyration of the insulin. Diafiltration removes the aggregates by size and pH cycling dissolves the aggregates by adjusting the pH through the pI of the protein. Pre‐treating the insulin with either pH cycling or diafiltration allowed reproducible kinetics of fibrillation for the insulin protein. Microaggregates are a common problem in protein production, formulation, and preparation; here we show that they are the main cause for inconsistent behavior and how pH cycling and diafiltration can mitigate this problem. Biotechnol. Bioeng. 2011; 108:237–241. © 2010 Wiley Periodicals, Inc.
Inhibition Mode of Soybean Lipoxygenase‐1 by Quercetin
Authors: Ha Tae Joung , Shimizu Kuniyoshi , Ogura Tetsuya , Kubo Isao 
Published: August 2010

AbstractQuercetin noncompetitively inhibited the peroxidation of linoleic acid catalyzed by soybean lipoxygenase‐1 (EC 1.13.11.12, Type 1) with an IC50 value of 4.8 μM (1.45 μg/ml). This inhibition is considered to proceed in sequential order, by initially reducing the ferric form of the enzyme to an inactive ferrous form and then, by chelating the iron of the active site of the enzyme. In the pseudoperoxidase assay, quercetin was slowly oxidized by hydroperoxides to a rather stable intermediate, 2‐(3,4‐dihydroxybenzoyl)‐2,4,6‐trihydroxybenzofuran‐3(2H)‐one, and this oxidized intermediate still inhibited the enzymatic oxidation, probably as a chelator. Rutin and kaempferol also exhibited lipoxygenase‐1 inhibitory activity, but to a much lesser extent than quercetin.
Geographic and Phenotypic Variation in Heartwood and Essential‐Oil Characters in Natural Populations of Santalum austrocaledonicum in Vanuatu
Authors: Page Tony , Southwell Ian , Russell Mike , Tate Hanington , Tungon Joseph , Sam Chanel , Dickinson Geoff , Robson Ken , Leakey Roger R. B. 
Published: August 2010

AbstractPhenotypic variation in heartwood and essential‐oil characters of Santalum austrocaledonicum was assessed across eleven populations on seven islands of Vanuatu. Trees differed significantly in their percentage heartwood cross‐sectional area and this varied independently of stem diameter. The concentrations of the four major essential‐oil constituents (α‐santalol, β‐santalol, (Z)‐β‐curcumen‐12‐ol, and cis‐nuciferol) of alcohol‐extracted heartwood exhibited at least tenfold and continuous tree‐to‐tree variation. Commercially important components α‐ and β‐santalol found in individual trees ranged from 0.8–47% and 0–24.1%, respectively, across all populations, and significant (P<0.05) differences for each were found between individual populations. The Erromango population was unique in that the mean concentrations of its monocyclic ((Z)‐β‐curcumen‐12‐ol and cis‐nuciferol) sesquiterpenes exceeded those of its bi‐ and tricyclic (α‐ and β‐santalol) sesquiterpenes. Heartwood colour varied between trees and spanned 65 colour categories, but no identifiable relationships were found between heartwood colour and α‐ and β‐santalol, although a weak relationship was evident between colour saturation and total oil concentration. These results indicate that the heartwood colour is not a reliable predictive trait for oil quality. The results of this study highlight the knowledge gaps in fundamental understanding of heartwood biology in Santalum genus. The intraspecific variation in heartwood cross‐sectional area, oil concentration, and oil quality traits is of considerable importance to the domestication of sandalwood and present opportunities for the development of highly superior S. austrocaledonicum cultivars that conform to the industry's International Standards used for S. album.
Glycoalkaloid Profile in Potato Haploids Derived from Solanum tuberosum–S. bulbocastanum Somatic Hybrids
Authors: Carputo Domenico , Savarese Salvatore , Andolfi Anna , Aversano Riccardo , Cimmino Alessio , Frusciante Luigi , Evidente Antonio 
Published: August 2010

AbstractCultivated and wild potato species synthesize a wide variety of steroidal glycoalkaloids (GA) that may affect either human health or biotic stress resistance. Therefore, GA composition must be a major criterion in the evaluation of breeding products when species genomes are merged and/or manipulated. This work reports the results of GA analysis performed on unique haploid (2n=2x=24) plants obtained from tetraploid (2n=4x=48) Solanum bulbocastanum–S. tuberosum hybrids through in vitro anther culture. Glycoalkaloids were extracted from tubers and analyzed by HPLC. Haploids generally showed the occurrence of parental GA. However, in several cases loss of parental GA and gain of new GA lacking in the parents was observed. It may be hypothesized that new GA profiles of our haploids is the result of either genetic recombination or combinatorial biochemistry events. To highlight differences between haploids and parents, soluble proteins and antioxidant activities were also determined. Both were always higher in haploids compared to their parents. The nature of the newly formed GAs will be further investigated, because they may represent new metabolites that can be used against pest and diseases, or are useful for human health.
Insecticidal Activity and Chemical Composition of the Essential Oils of Artemisia lavandulaefolia and Artemisia sieversiana from China
Authors: Liu Zhi Long , Liu Quan Ru , Chu Sha Sha , Jiang Guo Hua 
Published: August 2010

AbstractIn our screening program for new agrochemicals from local wild plants, Artemisia lavandulaefolia and A. sieversiana were found to possess insecticidal activity against the maize weevil Sitophilus zeamais. The essential oils of the aerial parts of the two plants were obtained by hydrodistillation and analyzed by GC and GC/MS. The main components of A. lavandulaefolia oil were caryophyllene (15.5%), β‐thujone (13.8%), eucalyptol (13.1%), and β‐farnesene (12.3%), and the principal compounds identified in A. sieversiana oil were eucalyptol (9.2%), geranyl butyrate (9.2%), borneol (7.9%), and camphor (7.9%). The essential oils of A. lavandulaefolia and A. sieversiana possessed fumigant toxicity against S. zeamais adults with LC50 values of 11.2 and 15.0 mg/l air, respectively. Both essential oils also showed contact toxicity against S. zeamais adults with LD50 values of 55.2 and 112.7 μg/adult, respectively.
Inhibition of P‐Glycoprotein‐Induced Multidrug Resistance by a Clerodane‐Type Diterpenoid fromSindora sumatrana
Authors: Jung Ho Jin , Chung Soo Yeon , Nam Joo‐Won , Chae Song Wha , Lee Yoo‐Jin , Seo Eun‐Kyoung , Lee Hwa Jeong 
Published: August 2010

AbstractThe aim of the present study was to investigate the effects of di‐ and sesquiterpenoids isolated from the pods ofSindora sumatranaMiq.(Leguminosae) on P‐glycoprotein (P‐gp) function in an adriamycin‐resistant human breast cancer cell line, MCF‐7/ADR. Over‐expression of P‐gp is known to be one of the mechanisms involved in multidrug resistance (MDR), which is a major obstacle in clinical cancer treatment. Among six di‐ and sesquiterpenoids extracted fromS. sumatrana, (+)‐7β‐acetoxy‐15,16‐epoxycleroda‐3,13(16),14‐trien‐18‐oic acid (1) showed a strong P‐gp inhibitory effect, as great as that of verapamil, a representative P‐gp inhibitor. Compound1enhanced daunomycin accumulation more than fourfold and significantly decreased daunomycin efflux compared with control, resulting in a decrease in theIC50value for daunomycin. These results suggest that compound1inhibits the functioning of P‐gp and, therefore, can be developed as an MDR‐reversing agent.
ChemInform Abstract: The Crystal Structure of the Sodium Oxohydroxoaluminate Hydrate Na2( Al2O3(OH)2)×1.5 H2O.
Authors: WEINBERGER M. , SCHNEIDER M. , MUELLER D. , GESSNER W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Modification of α‐Al2O3 Platelet/ZrO2 Matrix Interface by Epitaxial Growth of β′′‐Al2O3 on the α‐Al2O3.
Authors: HUANG X.‐N. , KUO C. K. , NICHOLSON P. S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gas‐Phase Reactions of HO‐2×CO2 with Molecular Species of Possible Atmospheric Interest.
Authors: WINCEL H. , MEREAND E. , CASTLEMAN A. W. JUN. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Gas Phase Synthesis, Structure, and Dissociation of Boron Triazide.
Authors: MULINAX R. L. , OKIN G. S. , COOMBE R. D. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The New Phosphide Ni5Ge2P3 and Its Structure.
Authors: ORISHCHIN S. V. , KUZ'MA YU. B. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Palladium‐Catalyzed Carbonyl Allylation of Aldehydes by Allylic Cyclic Carbonates.
Authors: KANG S.‐K. , PARK D.‐C. , PARK C.‐H. , JANG S.‐B. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bis(sulfonyl) Ketones: A New Oxyallyl Cation Source.
Authors: HARDINGER S. A. , BAYNE C. , KANTOROWSKI E. , MCCLELLAN R. , LARRES L. , NUESSE M.‐A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chromium and Tungsten Pentacarbonyl Groups as Reactivity and Selectivity Auxiliaries in (3 + 2) Cycloaddition of Alkynyl Fischer Carbene Complexes with N‐Alkyl Nitrones.
Authors: CHAN K. S. , YEUNG M. L. , CHAN W. , WANG R.‐J. , MAK T. C. W. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Free Radical Approach to Directed Aldol‐Type Reactions Promoted by Allylic O‐Stannyl Ketyls.
Authors: ENHOLM E. J. , XIE Y. , ABBOUD K. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbonyl Coupling Reactions Catalytic in Titanium and the Use of Commercial Titanium Powder for Organic Synthesis.
Authors: FUERSTNER A. , HUPPERTS A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Novel Cycloocta(d)‐/Barreleno(d)pyridazine Rearrangement.
Authors: BAUMANN L. , FOLKERTS A. , IMMING P. , KLINDERT T. , MASSA W. , SEITZ G. , WOCADLO S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Coupling of Thiols and Selenols Catalyzed by Tris(trinitratocerium(IV)) paraperiodate.
Authors: IRANPOOR N. , SALEHI P. , SHIRINY F. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple Allylic Amination Procedure and the Metathesis of N‐ Sulfinylcarbamates.
Authors: KATZ T. J. , SHI S. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Tetrahydropyridin‐4‐one Enamines with Chlorides of α, β‐Unsaturated Acids.
Authors: BUTKUS E. , BELINITE‐VIL'YAMS B. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dimethoxybenzoin Carbonates: Photochemically Removable Alcohol Protecting Groups Suitable for Phosphoramidite‐Based DNA Synthesis.
Authors: PIRRUNG M. C. , BRADLEY J.‐C. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cupration of Organomercurials: A Mild Method for the Intramolecular Addition of Organometallics to Ester Groups.
Authors: KOCOVSKY P. , GRECH J. M. , MITCHELL W. L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Migration of Groups from Zirconium to Boron: Aspects of Synthesis and Utility.
Authors: QUINTANILLA R. , COLE T. E. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Functionalized Diquinanes via Electrophilic Cyclobutene Intermediates.
Authors: FRANCK‐NEUMANN M. , MIESCH M. , GROSS L. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: General Synthetic Methods. Part 2. Reactions of 2‐Phenylthio‐2‐ cycloalkenones and 2‐(Phenyl(thiomethyl))‐ 2‐Cycloalkenones: Synthesis of Some Useful Chiral and Achiral Intermediates.
Authors: VANKAR Y. D. , KUMARAVEL G. , BHATTACHARYA I. , VANKAR P. S. , KAUR K. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reductive Deoxygenation of Indan‐1‐ols by ZnI2/NaCNBH3.
Authors: ALESSO E. N. , BIANCHI D. E. , FINKIELSZTEIN L. M. , LANTANO B. , MOLTRASIO G. Y. , AGUIRRE J. M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Interaction of Fullerene C60 with Iodine in Organic Solvents.
Authors: TURANOV A. N. , KREMENSKAJA I. N. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Efficient Synthesis of 3‐Amino‐1‐phenylpyrrole (III).
Authors: FABIS F. , DALLEMAGNE P. , RAULT S. , ROBBA M. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Anticonvulsant Activity of Some New Thiosemicarbazone and 4‐Thiazolidone Derivatives Bearing an Isatin Moiety.
Authors: KARALI N. , GUERSOY A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Steric Effects in the Synthesis of Pyrroloindoles from 5‐Aminoindoles.
Authors: YAMASHKIN S. A. 
Published: August 2010

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.