bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes and risk factors associated with in-hospital mortality in patients undergoing coronary artery bypass grafting with low ejection fraction
Authors: Zhao Yang , Yu Xu , Ma Xiaolong , Zhang Liang , Wang Zehui 
Published: February 2025

ObjectiveTo investigate the short-term prognosis and risk factors associated with in-hospital mortality in patients undergoing coronary artery bypass grafting (CABG) with low ejection fraction.MethodsClinical data were collected from 765 patients who underwent CABG with an ejection fraction of less than 40% between 2019 and 2023 at Anhui Chest Hospital and Beijing Anzhen Hospital, Capital Medical University. The patients were categorized into a in-hospital mortality group (n = 38) and a in-hospital survival group (n = 727), based on whether they died within 30 days post-operation. Univariate and multivariate logistic regression analyses were employed to identify risk factors for in-hospital mortality. The relationship between these risk factors and the likelihood of in-hospital mortality was assessed using restricted cubic splines (RCS). Additionally, predictive values were evaluated by plotting receiver operating characteristic curves (ROC).ResultsIn-hospital mortality occurred in 38 out of the 765 patients, resulting in an incidence rate of 4.97%. Compared to the survival group, those in the mortality group exhibited significantly higher rates of exploratory thoracotomy, intra-aortic balloon pump usage, extracorporeal membrane oxygenation application, gastrointestinal bleeding incidents, and acute renal failure occurrences. Independent risk factors for in-hospital mortality included preoperative age, left ventricular ejection fraction (LVEF), fasting glucose levels (Glu), and glomerular filtration rate (eGFR). Conversely, standardized preoperative administration of oral nitrates and aspirin as well as intraoperative utilization of internal mammary arteries emerged as protective factors against in-hospital mortality. ROC analysis revealed predictive efficiencies for age at 68.5%, LVEF at 76.6%, Glu at 60.5%, while eGFR demonstrated a predictive efficiency of 78.1%.ConclusionThe incidence of in-hospital mortality in patients undergoing coronary artery bypass grafting with low ejection fraction is correlated with several factors, including advanced age, LVEF, Glu, eGFR, and the standardized preoperative administration of oral nitrates and aspirin. These findings serve as a guide for enhancing the in-hospital prognosis for this patient population in clinical practice.
Angiogenesis after acute myocardial infarction: a bibliometric -based literature review
Authors: Tan Yu , Li Min , Ma Xiaojuan , Shi Dazhuo , Liu Wei 
Published: February 2025

ObjectiveThe prevalence of acute myocardial infarction, a severe ischemic cardiac disease, is on the rise annually. The establishment of coronary collateral circulation in the border zone of the infarct can effectively relieve myocardial ischemia and impede cell death, while angiogenesis can promote the formation of collateral circulation in the ischemic tissues. Over the past two decades, studies related to angiogenesis in acute myocardial infarction have increased rapidly. However, there is a lack of bibliometric studies in this particular field.MethodsFor this study, we employed bibliometric analysis to outline focal points and patterns in scientific and clinical research. The collection of literature was gathered using the Web of Science Core Collection database. Bibliometric and visual analysis were conducted. Knowledge maps were generated using CiteSpace and VOSviewer software.Results and conclusionsWith the deepening of the research, therapeutic angiogenesis will become a treatment direction for acute myocardial infarction in the future.
Transcriptomic analysis of the effects exerted by curcumin on dihydrotestosterone-induced ovarian granulosa cells
Authors: Chen Dejian , Yu Qian , Sheng Shuhao , Cai Lingshi , Zheng Jisuo , Zhang Yaling 
Published: February 2025

PurposeHyperandrogenism is a leading cause of developmental retardation in ovarian granulosa cells. Previous studies have indicated that curcumin significantly improves follicular dysplasia, a characteristic of the polycystic ovary syndrome. Our purpose was to explore the signaling pathways which enable curcumin to protect the development of hyperandrogen-induced granulosa cells.MethodsOvarian granulosa cells treated with or without curcumin at different dihydrotestosterone (DHT) levels, were screened for cell viability, reactive oxygen species production, and apoptosis. RNA sequencing (transcriptome sequencing) was used to determine global gene expression in DHT-induced granulosa cells treated with curcumin.Results24 hours of combined curcumin and DHT treatment inhibited granulosa cell viability in a dose-dependent manner. Curcumin upregulated estrogen synthesis-related enzymes, downregulated lipid metabolism-related genes and the glucuronic acid process, inhibited androgen receptor (AR) activity, significantly improved cell viability, and corrected granulosa cell development. Gene set enrichment and genome transcriptome pathway analyses revealed the potential role played by curcumin in protecting granulosa cell development.ConclusionHigh androgen levels may disrupt steroid hormone synthesis and lipid metabolism pathways associated with granulosa cell development, thereby activating AR and inhibiting estrogen biosynthesis. Curcumin restores granulosa cell development by correcting abnormal steroid gene expression and disordered lipid fatty acid metabolism.
Trimethylamine N-oxide (TMAO) acutely alters ionic currents but does not increase cardiac cell death
Authors: Esposito Simona , McGuinness Lauren R. , Sharma Parveen , Chadwick Amy E. , Rainbow Richard D. 
Published: February 2025

BackgroundTrimethylamine N-oxide (TMAO) is a product of the action of gut microbiota on choline and other choline-containing compounds ingested in the diet. The presence of TMAO at high concentrations has been reported in the blood of patients with cardiovascular disease, suggesting the role for TMAO as either a marker or causative agent of the disease. These investigations examined whether TMAO had an effect on cardiomyocyte contractile function, calcium homoeostasis, and survival from metabolic insult.ResultsTMAO had no effect on metabolic function or the ability of cells to survive a metabolic insult; however, it did cause transient changes to contractile function. These changes included an increase in calcium current and an increase in Kir6.1 channel activity in the cell, causing a shortening of the action potential duration to 90% repolarised but lengthening the action potential to 30% repolarised. These effects occurred within minutes of TMAO application; however, they were not observed following 24 h culture. These data suggest that TMAO does modulate contractile function, albeit only in the short-term, but has no effect on metabolic behaviour or the ability to withstand a metabolic challenge.ConclusionThese data suggest that high TMAO concentrations in the blood of patients may be a marker of potential cardiovascular disease rather than playing a causative role.
Balancing accuracy and user satisfaction: the role of prompt engineering in AI-driven healthcare solutions
Authors: Wang Mini Han , Jiang Xudong , Zeng Peijin , Li Xinyue , Chong Kelvin Kam-Lung , Hou Guanghui , Fang Xiaoxiao , Yu Yang , Yu Xiangrong , Fang Junbin , Pan Yi 
Published: February 2025

IntroductionThe rapid evolution of the Internet of Things (IoT) and Artificial Intelligence (AI) has opened new possibilities for public healthcare. Effective integration of these technologies is essential to ensure precise and efficient healthcare delivery. This study explores the application of IoT-enabled, AI-driven systems for detecting and managing Dry Eye Disease (DED), emphasizing the use of prompt engineering to enhance system performance.MethodsA specialized prompt mechanism was developed utilizing OpenAI GPT-4.0 and ERNIE Bot-4.0 APIs to assess the urgency of medical attention based on 5,747 simulated patient complaints. A Bidirectional Encoder Representations from Transformers (BERT) machine learning model was employed for text classification to differentiate urgent from non-urgent cases. User satisfaction was evaluated through composite scores derived from Service Experiences (SE) and Medical Quality (MQ) assessments.ResultsThe comparison between prompted and non-prompted queries revealed a significant accuracy increase from 80.1% to 99.6%. However, this improvement was accompanied by a notable rise in response time, resulting in a decrease in SE scores (95.5 to 84.7) but a substantial increase in MQ satisfaction (73.4 to 96.7). These findings indicate a trade-off between accuracy and user satisfaction.DiscussionThe study highlights the critical role of prompt engineering in improving AI-based healthcare services. While enhanced accuracy is achievable, careful attention must be given to balancing response time and user satisfaction. Future research should optimize prompt structures, explore dynamic prompting approaches, and prioritize real-time evaluations to address the identified challenges and maximize the potential of IoT-integrated AI systems in medical applications.
Health care experiences of individuals accessing or undergoing in vitro fertilization (IVF) in the U.S.: a narrative review of qualitative studies
Authors: Peterson Summer K. , Jennings Mayo-Wilson Larissa , Spigel Lauren , Morgan Isabel , Parker Adriana 
Published: February 2025

BackgroundIn vitro fertilization (IVF) is an increasingly common method of assisted reproduction given the high rates of infertility in the United States (U.S.). However, despite growing utilization of IVF technologies, there is little known about the experiences of those accessing or undergoing IVF, particularly among adults in the U.S. The aims of this review are to (1) explore how economic, emotional and physical health, and interpersonal relationships impact and are impacted by accessing or undergoing IVF, and (2) understand the role of healthcare providers and the healthcare system.MethodsA narrative review was conducted to summarize the current literature and provide insight into potential channels for care improvement. Eligible studies were published in English from 2013 to 2024 which qualitatively evaluated experiences of individuals and couples accessing or undergoing IVF. Peer-reviewed publications were identified from three electronic bibliographic databases. Methodologic rigor was assessed by two reviewers who also abstracted data on the study's characteristics as they pertained to four domains: health systems, economic, interpersonal, and physical and emotional health. Among the 32 papers retrieved for review, 22 met inclusion criteria and were retained for analysis.ResultsThe available literature suggests accessing and undergoing IVF can be positively and negatively influenced by health systems, economic, interpersonal, and physical and emotional health factors. Often an individual or couple experiences multiple factors that compound to create a complex situation. Health systems-related factors included physician interaction and challenges with information volume and processing. Economic challenges primarily pertained to financing IVF and navigating insurance coverage. Interpersonal factors related to changes in relationships with partners, family members, and friends due to IVF. Physical health concerns (e.g., pain) and emotional health concerns (e.g., sadness, stress) were also noted by all included papers.ConclusionsEfforts to improve care experiences of adults accessing or undergoing IVF are urgently needed. The evidence base points to a need for provider sensitivity trainings, clinic-based intervention, and community education in both physical and virtual spaces.
Simultaneous determination of the amylose and amylopectin content of foxtail millet flour by hyperspectral imaging
Authors: Wang Guoliang , Liu Min , Xue Hongtao , Guo Erhu , Zhang Aiying 
Published: February 2025

The levels of amylose and amylopectin in foxtail millet are important factors that influence grain quality. The application of organic fertilizers can affect the ratio of amylose and amylopectin components. These components are typically determined using chemical analysis methods, which are difficult to apply on a large scale for nutrient deficiency diagnosis and do not meet the original intention of precise agricultural development. This study set up five different gradient treatments for organic fertilizer (sheep manure) application. Hyperspectral imaging combined with chemometrics was employed to achieve rapid and non-destructive detection of the content of amylose and amylopectin in foxtail millet flour. The aim of this study was to determine the optimal dosage of organic fertilizers for application. Spectral data preprocessing used multiplicative scatter correction (MSC), and the combined algorithm of competitive adaptive reweighted sampling (CARS), random frog (RF), and iterated retaining informative variables (IRIVs) was employed for key band extraction. Partial least squares regression (PLSR) was then used to establish the prediction model and regression equation, which was used to visualize the two components. Results demonstrated that the key band extraction combined algorithm effectively reduced data dimension without compromising the accuracy of the prediction model. The prediction model for amylose using MSC–RF–IRIV–PLSR exhibited good performance, with the correlation coefficient (R) and root mean square error (RMSE) predicted to be 0.73 and 1.23 g/(100 g), respectively. Similarly, the prediction model for amylopectin using MSC–CARS–IRIV–PLSR also demonstrated good performance, with the R and RMSE values predicted to be 0.59 and 7.34 g/(100 g), respectively. The results of visualization and physicochemical determination showed that the amount of amylopectin accumulation was highest, and the amount of amylose was lowest, under the application of 22.5 t/ha of organic fertilizer. The experimental results offer valuable insights for the rapid detection of nutritional components in foxtail millet, serving as a basis for further research.
The Influence of Chemical Composition on Cobalt-Based Alloys
Authors: MINCIUNA Mirabela Georgiana , VIZUREANU Petrică 
Published: February 2025

Cobalt-based alloys contain up to 50% cobalt, which means that they provide the material with increased abrasion resistance at high temperatures. Cobalt is similar to nickel because it is a hard material that is very resistant to wear and corrosion, especially at high temperatures. It is generally used as an element in alloys, due to its resistance to corrosion, but also due to its magnetic properties. In all cases, the introduction of an implant into an organism is likely to induce chemical, mechanical, electrical, thermal, magnetic and atomic interactions.
Studies and Research on the Replacement of Pipes Made of Steel P355N, Intended for Domestic Water
Authors: TUDOR Beatrice Daniela , STERIAN Dumitra 
Published: February 2025

The paper presents an analysis regarding the need to replace pipes made of P355N steel, intended for domestic water. This replacement presents a necessity, due to the degradation and exceeding the lifespan of the domestic water network in the city of Galati. The microscopic analysis of the samples from steel pipe, shows an advanced degree of degradation of the steel pipes. The pipes will be replaced with polypropylene pipes, which have certain advantages in terms of corrosion resistance and in terms of ease of intervention in case of damage in the water network.
Сравнение методов обратного осмоса и электродиализа при деминерализации природных и сточных вод
Authors: Вурдова Н.Г. 
Published: February 2025

Деминерализация воды играет ключевую роль в различных отраслях, включая энергетическую, химическую и пищевую промышленность, а также при очистке сточных вод для организации замкнутых водооборотных систем. Основными методами деминерализации являются обратный осмос и электродиализ. Проведен сравнительный анализ этих методов с точки зрения их эффективности, экономичности, экологической безопасности и применимости для очистки сточных вод. Особое внимание уделено механизму процессов, энергетическим затратам, эксплуатационным характеристикам и требованиям к предварительной обработке воды. Установлены три ключевых критерия, по которым следует сравнивать оба рассматриваемых метода: необходимость предварительной подготовки воды, частота замены мембран и энергоемкость процесса.
Water demineralization plays a key role in various industries, including energy, chemical and food industries, as well as in wastewater treatment to provide for a closed water recycling systems. The main methods of demineralization are reverse osmosis and electrodialysis. A comparative analysis of these methods is carried out in terms of their efficiency, cost-effectiveness, environmental safety and applicability in wastewater treatment. Particular attention is paid to the mechanism of the processes, energy costs, operational characteristics and requirements to water pre-treatment. Three key criteria are established needed to compare both methods considered: the need for water pre-treatment, the membrane replacement frequency, and the energy intensity of the process.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEPATUHAN MENGKONSUMSI TABLET FE PADA IBU HAMIL DI PMB HUSNIYATI KOTA PALEMBANG
Authors: Inayah Maudila , Puspita  Sari Erma , Rahmawati Eka , Aisyah Siti 
Published: February 2025

Menurut World Health Organization (WHO), diperkirakan sekitar 33% orang di seluruh dunia menderita anemia, dengan kekurangan zat besi diyakini sebagai penyebab utamanya, dan anemia merupakan salah satu masalah kecacatan utama setiap tahunnya 9% per tahun. Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan, dukungan keluarga dan peran tenaga kesehatan secara simultan dengan kepatuhan mengkonsumsi tablet Fe pada ibu hamil di PMB Husniyati Palembang Tahun 2024. Jenis penelitian ini adalah kuantitatif dengan menggunakan motode survey analitik dengan pendekatan cross sectional. Populasi dalam penelitian ini semua ibu hamil yang ditemui atau kebetulan ada berkunjung untuk periksa kehamilannya di PMB Husniyati. Sampel pada penelitian ini menggunakan teknik accidental sampling. Data di analisis dengan uji statistik chi-square. Hasil analisi univariat yang peneliti dapat berjumlah 50 responden, ibu yang pengetahuan baik sebanyak 42 responden dan ibu yang pengetahuan kurang baik sebanyak 8 responden (16,0%), ibu yang keluarganya positif mendukung sebanyak 32 responden (64,0%) dan ibu yang negatif mendapatkan dukungan sebanyak 18 responden (36,0%), dan ibu dengan peran tenaga kesehatan baik 40 responden (80,0%) dan ibu dengan peran tenaga kesehatan tidak baik 10 responden (20,0%). Hasil analisa bivariat uji chi-square diperoleh Pengetahuan (p-value 0,014), Dukungan Keluarga (p-value 0,025), dan Peran Tenaga Kesehatan (p-value 0,046). Bahwa dapat di simpulkan bahwa benar ada hubungan antara pengetahuan, dukungan keluarga dan peran tenaga kesehatan dengan kepatuhan mengkonsumsi tablet Fe pada ibu hamil di PMB Husniyati tahun 2024. Hasil penelitian ini diharapkan bagi tenaga kesehatan untuk menerapkan penggunaan kartu pemantauan tablet Fe bagi Ibu hamil yang menerima tablet Fe di PMB
In Vitro Inhibition Test of Turmeric and in Vivo Total Bacterial Count in the Intestinal Digesta of Mojosari Duck Fed Diet Containing Graded Levels of Turmeric
Authors: Ardiansyah Widiastuti , Achmad Dewi Shinta , Akbar Muh Firyal 
Published: February 2025

This study aimed to determine the inhibition value of turmeric (Curcuma longa) against Salmonella and Escherichia coli and evaluate the bacterial population in the small intestinal digesta of Mojosari ducks. This study was arranged using a Completely Randomized Design (CRD) with six treatments and four replications; eachreplication consisted of eight Mojosari ducks.The in vitro study used four treatments of different concentrations of turmeric, consisting of Control/only water (C0), turmeric 98% + 2% water(C1), Probiotic 98% and 2% water (C2), turmeric 92%, and probiotic 8% (C3),and Bacitracin 92% + water 8% (C4). Then, the inhibition zone diameter was measured using the agar well diffusion method. On the other hand, the in vivo study was carried out by employing 192 Mojosari duck raised for 60 days. They were given the following dietary treatments, namely T0= basal diet, T1= basal diet supplemented with turmeric 0.2%, T2= basal diet supplemented with supplemented with turmeric 0.8%, T3= basal diet supplemented with turmeric 0.2%+probiotic 0.1% and T4=feed basal supplemented with supplemented with turmeric 0.8% + probiotic 0.6%, and T5 = basal diet + Zinc Bacitracin 0.01%. The variables measured were the total bacterial population based on the Total Plate Count (TPC) in the small intestinal digesta of Mojosari ducks. The Data were analyzed using one-way ANOVA. The differences among means were tested using theLeast Significant Difference (LSD) test.
L’antimodèle : les racines de la critique de la social-démocratie en Suède après 1945
Authors: Aucante Yohann 
Published: February 2025

Souvent présentée comme idyllique et source d’inspiration pour de nombreux autres pays, la social-démocratie a aussi été la cible de nombreuses critiques. Dès les années 1930, la voie suédoise est un modèle pour les États-Unis d’Amérique et cette influence s’étendra à de nombreux pays dans les décennies suivantes. Les critiques se font cependant plus vives après 1945, et particulièrement dans les années 1960-1970, alors que la crise fiscale, la critique d’un État parfois présenté comme tentaculaire et celle d’une démocratie pervertie par la domination sociale-démocrate se développent. Cette critique s’accompagne dans les décennies 1970 et 1980 de l’émergence d’une alternative idéologique libérale de plus en plus structurée et vigoureuse, soutenue par le patronat. S’y ajoute une remise en cause encore plus radicale dans les années 1990 avec la mise en lumière d’une histoire de politiques de stérilisation forcée ou de surveillance des opposants politiques (communistes).