bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individual Brain Charting dataset extension, third release for movie watching and retinotopy data
Authors: Pinho Ana Luísa , Richard Hugo , Ponce Ana Fernanda , Eickenberg Michael , Amadon Alexis , Dohmatob Elvis , Denghien Isabelle , Torre Juan Jesús , Shankar Swetha , Aggarwal Himanshu , Thual Alexis , Chapalain Thomas , Ginisty Chantal , Becuwe-Desmidt Séverine , Roger Séverine , Lecomte Yann , Berland Valérie , Laurier Laurence , Joly-Testault Véronique , Médiouni-Cloarec Gaëlle , Doublé Christine , Martins Bernadette , Varoquaux Gaël , Dehaene Stanislas , Hertz-Pannier Lucie , Thirion Bertrand 
Published: June 2024

AbstractThe Individual Brain Charting (IBC) is a multi-task functional Magnetic Resonance Imaging dataset acquired at high spatial-resolution and dedicated to the cognitive mapping of the human brain. It consists in the deep phenotyping of twelve individuals, covering a broad range of psychological domains suitable for functional-atlasing applications. Here, we present the inclusion of task data from both naturalistic stimuli and trial-based designs, to uncover structures of brain activation. We rely on the Fast Shared Response Model (FastSRM) to provide a data-driven solution for modelling naturalistic stimuli, typically containing many features. We show that data from left-out runs can be reconstructed using FastSRM, enabling the extraction of networks from the visual, auditory and language systems. We also present the topographic organization of the visual system through retinotopy. In total, six new tasks were added to IBC, wherein four trial-based retinotopic tasks contributed with a mapping of the visual field to the cortex. IBC is open access: source plus derivatives imaging data and meta-data are available in public repositories.
Gallic acid pretreatment mitigates parathyroid ischemia–reperfusion injury through signaling pathway modulation
Authors: Liu Nianqiu , Liang Hongmin , Hong Yuan , Lu Xiaokai , Jin Xin , Li Yuting , Tang Shiying , Li Yihang , Cao Weihan 
Published: June 2024

AbstractThyroid surgery often results in ischemia–reperfusion injury (IRI) to the parathyroid glands, yet the mechanisms underlying this and how to ameliorate IRI remain incompletely explored. Our study identifies a polyphenolic herbal extract—gallic acid (GA)—with antioxidative properties against IRI. Through flow cytometry and CCK8 assays, we investigate the protective effects of GA pretreatment on a parathyroid IRI model and decode its potential mechanisms via RNA-seq and bioinformatics analysis. Results reveal increased apoptosis, pronounced G1 phase arrest, and significantly reduced cell proliferation in the hypoxia/reoxygenation group compared to the hypoxia group, which GA pretreatment mitigates. RNA-seq and bioinformatics analysis indicate GA’s modulation of various signaling pathways, including IL-17, AMPK, MAPK, transient receptor potential channels, cAMP, and Rap1. In summary, GA pretreatment demonstrates potential in protecting parathyroid cells from IRI by influencing various genes and signaling pathways. These findings offer a promising therapeutic strategy for hypoparathyroidism treatment.
Effects of protein-enriched nutritional support on skeletal muscle mass and rehabilitative outcomes in brain tumor patients: a randomized controlled trial
Authors: Cho Kye Hee , Han Eun Young , Jung Min Kyu , Kang Chang Moo , Shin Ji Cheol , Im Sang Hee 
Published: June 2024

AbstractPatients with brain tumors require extensive and prolonged rehabilitation efforts as they suffer from lesion-induced motor weakness as well as treatment-related side effects, often leading to a significant decline in function. Protein supplements have shown positive effects on promoting muscle strength and physical performance in various tumor etiologies. However, reports on their effects specifically in brain tumor patients remain scarce. This study aims to investigate the feasibility and efficacy of protein supplements in enhancing rehabilitative outcomes via muscle strengthening and functional gain in brain tumor patients with neurological demise. Sixty brain tumor patients were randomly assigned to either a protein supplement or a control group, receiving either protein supplements or a placebo for 6 weeks, in conjunction with conventional rehabilitation therapy. Assessments before and after the intervention included laboratory tests, anthropometric measures using bioimpedance analysis, and functional assessments, which included the MMSE, the modified Barthel Index, the Beck Depression Inventory, the Brief Fatigue Inventory, the Timed Up and Go test, the 6-min walk test, the isokinetic quadriceps muscle strength test, and the handgrip power. After the intervention, the levels of serum hemoglobin, protein, albumin, and C-reactive protein were improved in both groups, however, the change was significant only in the protein group. The muscle strength was enhanced in both groups, however, the significant increase in pinch grasp power was only noted in the protein group (P < 0.05). The distance on 6MWT was also significantly extended at follow-up in the protein group (P < 0.01). In the subgroup analysis according to nutritional status, the moderate malnutrition group showed greater augmentation of muscle mass than those with adequate nutrition (P < 0.05). Interestingly, the amelioration of malnutrition was observed only the in protein group. This study using protein supplements to promote the rehabilitative potential of brain tumor patients revealed a significant effect on improving hemodynamic nutritional indices, muscle power reimbursement, and functional improvement, especially in malnourished patients. The safety and feasibility of protein supplements in brain tumor patients were affirmative in this study. Further studies with more patients may help confirm the secondary functional gain resulting from increased muscle power.Trial registration: This study was retrospectively registered in the Clinical Research Information Service, CRIS no. KCT0009113 on Jan 12, 2024.
Urban 3D building morphology and energy consumption: empirical evidence from 53 cities in China
Authors: Wang Yang , Sun Guiquan , Wu Yingmei , Rosenberg Mark W. 
Published: June 2024

AbstractThe impact of building morphology on building energy consumption has been extensively studied. However, research on how 3D building morphology affects energy consumption at a macroscopic scale is lacking. In this study, we measured the mean building height (BH), mean building volume (BV), and mean European nearest neighbor distance (MENN) of the city to quantify the 3D building morphology. We then used a spatial regression model to analyze the quantitative impact of urban 3D building morphology on per capita electricity consumption (PCEC). Results indicate that at the macroscopic scale of the city, the BH and the MENN have a significant positive impact on the PCEC, while the BV has a significant negative impact on the PCEC. Moreover, the inclusion of the 3D building morphology greatly improves the model’s ability to explain building energy efficiency, surpassing the impact of traditional economic factors. Considering the 3D building morphology indicators together, buildings with a lower height, a larger volume, and a more compact 3D morphology have greater potential for energy savings and are more conducive to electricity conservation. This study offers valuable insights for the energy-efficient arrangement of buildings.
Effectiveness of remote pulmonary artery pressure estimating in heart failure: systematic review and meta-analysis
Authors: Urban Szymon , Szymański Oskar , Grzesiak Magdalena , Tokarczyk Wojciech , Błaziak Mikołaj , Jura Maksym , Fułek Michał , Fułek Katarzyna , Iwanek Gracjan , Gajewski Piotr , Ponikowski Piotr , Biegus Jan , Zymliński Robert 
Published: June 2024

AbstractHeart failure (HF) poses a significant challenge, often leading to frequent hospitalizations and compromised quality of life. Continuous pulmonary artery pressure (PAP) monitoring offers a surrogate for congestion status in ambulatory HF care. This meta-analysis examines the efficacy of PAP monitoring devices (CardioMEMS and Chronicle) in preventing adverse outcomes in HF patients, addressing gaps in prior randomized controlled trials (RCTs). Five RCTs (2572 participants) were systematically reviewed. PAP monitoring significantly reduced HF-related hospitalizations (RR 0.72 [95% CI 0.6–0.87], p = 0.0006) and HF events (RR 0.86 [95% CI 0.75–0.99], p = 0.03), with no impact on all-cause or cardiovascular mortality. Subgroup analyses highlighted the significance of CardioMEMS and blinded studies. Meta-regression indicated a correlation between prolonged follow-up and increased reduction in HF hospitalizations. The risk of bias was generally high, with evidence certainty ranging from low to moderate. PAP monitoring devices exhibit promise in diminishing HF hospitalizations and events, especially in CardioMEMS and blinded studies. However, their influence on mortality remains inconclusive. Further research, considering diverse patient populations and intervention strategies with extended follow-up, is crucial for elucidating the optimal role of PAP monitoring in HF management.
The cumulative live birth rate and cost-effectiveness of the clomiphene and gonadotropin cotreatment protocol versus the mid-luteal GnRH agonist protocol in women over 35 years old
Authors: Li Yanhui , Luo Dan , Li Tao , Ding Hui , Liu Yi 
Published: June 2024

AbstractThe decrease in assisted reproductive technology success among older women, attributed to decreased oocyte quantity and quality, poses a significant challenge. Currently, no consensus on the optimal ovarian stimulation protocol for older women undergoing IVF exists. This retrospectively registered cohort study aimed to compare the cumulative live birth rate (CLBR), time to live birth (TTLB), and cost-effectiveness among women older than 35 years who were receiving either the gonadotropin-releasing hormone agonist (GnRHa) or clomiphene citrate and gonadotropin cotreatment with ovarian stimulation (CC cotreatment) protocol. To compare treatment outcomes, we performed propensity score matching (PSM) on 2871 IVF cycles in women older than 35 years who received either the GnRHa or CC cotreatment protocol, resulting in 375 cycles in each group. Additionally, a decision tree model was utilized to assess the cost-effectiveness of the two protocols. Following PSM, both groups had similar baseline characteristics. The CC cotreatment protocol resulted in a greater rate of cycle cancellation (13.07% vs. 8.00%, p = 0.032), but the groups maintained comparable fertilization rates and embryo quality. Although the TTLB was longer in the CC cotreatment group, the CLBR per initial cycle (41.07% vs. 45.33%, p = 0.269) and delivery outcomes were similar between the two groups at the 24 months follow-up. Additionally, the average cost per live birth in the CC cotreatment group was 21.27% lower than in the GnRHa group (¥32,301.42 vs. ¥39,174.22). In conclusion, for women older than 35 years undergoing IVF, the CC cotreatment protocol offered a comparable CLBR to the GnRHa protocol but with reduced costs, indicating its potential as a viable and cost-effective ovarian stimulation option.Clinical trial registration: https://www.chictr.org.cn/, identifier [ChiCTR2300076537].
In-situ tool wear condition monitoring during the end milling process based on dynamic mode and abnormal evaluation
Authors: Chen Min , Mao Jianwei , Fu Yu , Liu Xin , Zhou Yuqing , Sun Weifang 
Published: June 2024

AbstractRapid tool wear conditions during the manufacturing process are crucial for the enhancement of product quality. As an extension of our recent works, in this research, a generic in-situ tool wear condition monitoring during the end milling process based on dynamic mode and abnormal evaluation is proposed. With the engagement of dynamic mode decomposition, the real-time response of the sensing physical quantity during the end milling process can be predicted. Besides, by constructing the graph structure of the time series and calculating the difference between the predicted signal and the real-time signal, the anomaly can be acquired. Meanwhile, the tool wear state during the end milling process can be successfully evaluated. The proposed method is validated in milling tool wear experiments and received positive results (the mean relative error is recorded as 0.0507). The research, therefore, paves a new way to realize the in-situ tool wear condition monitoring.
Efficacy of pyrethroid-pyriproxyfen and pyrethroid-chlorfenapyr nets on entomological indicators of malaria transmission: third year of a randomised controlled trial in Benin
Authors: Sovi Arthur , Yovogan Boulais , Adoha Constantin J. , Akinro Bruno , Accrombessi Manfred , Dangbénon Edouard , Assongba Landry , Salako Albert Sourou , Padonou Germain Gil , Messenger Louisa A. , Ngufor Corine , Cook Jackie , Protopopoff Natacha , Akogbéto Martin C. 
Published: June 2024

AbstractThe present cluster-randomised control trial aims to assess the entomological efficacy of pyrethroid-pyriproxyfen and pyrethroid-chlorfenapyr LLINs compared to the standard pyrethroid-only LLINs, in their third year of community usage. Adult mosquito collections were performed every 3 months, in 4 randomly selected houses in each of the 60 trial clusters, using human landing catches. Adult mosquitoes were morphologically identified and Anopheles vectors were molecularly speciated and screened for the presence of the L1014F kdr mutation using PCR. Plasmodium falciparum sporozoite infection was assessed using ELISA. A subset of An. gambiae s.l. was also dissected to examine parity and fertility rates across study arms. There was no evidence of a significant reduction in indoor vector density and entomological inoculation rate by the pyrethroid-pyriproxyfen [DR 0.94 (95% CI 0.46–1.88), p = 0.8527; and RR 1.10 (95% CI 0.44–2.72), p = 0.8380], and pyrethroid-chlorfenapyr [DR 0.74 (95% CI 0.37–1.48), p = 0.3946; and RR 1.00 (95% CI 0.40–2.50), p = 0.9957] LLINs, respectively. The same trend was observed outdoors. Frequencies of the L1014F kdr mutation, as well as parous and fertility rates, were similar between study arms. In the third year after net distribution, entomological indicators show that the two dual active-ingredients nets performed similarly to the standard pyrethroid-only LLIN. To maintain malaria gains, it is crucial that net distribution cycles fit with their operational lifespan.
Aggregation-resistant alpha-synuclein tetramers are reduced in the blood of Parkinson’s patients
Authors: de Boni Laura , Wallis Amber , Hays Watson Aurelia , Ruiz-Riquelme Alejandro , Leyland Louise-Ann , Bourinaris Thomas , Hannaway Naomi , Wüllner Ullrich , Peters Oliver , Priller Josef , Falkenburger Björn H , Wiltfang Jens , Bähr Mathias , Zerr Inga , Bürger Katharina , Perneczky Robert , Teipel Stefan , Löhle Matthias , Hermann Wiebke , Schott Björn-Hendrik , Brockmann Kathrin , Spottke Annika , Haustein Katrin , Breuer Peter , Houlden Henry , Weil Rimona S , Bartels Tim 
Published: June 2024

AbstractSynucleinopathies such as Parkinson’s disease (PD) are defined by the accumulation and aggregation of the α-synuclein protein in neurons, glia and other tissues. We have previously shown that destabilization of α-synuclein tetramers is associated with familial PD due to SNCA mutations and demonstrated brain-region specific alterations of α-synuclein multimers in sporadic PD patients following the classical Braak spreading theory. In this study, we assessed relative levels of disordered and higher-ordered multimeric forms of cytosolic α-synuclein in blood from familial PD with G51D mutations and sporadic PD patients. We used an adapted in vitro-cross-linking protocol for human EDTA-whole blood. The relative levels of higher-ordered α-synuclein tetramers were diminished in blood from familial PD and sporadic PD patients compared to controls. Interestingly, the relative amount of α-synuclein tetramers was already decreased in asymptomatic G51D carriers, supporting the hypothesis that α-synuclein multimer destabilization precedes the development of clinical PD. Our data, therefore suggest that measuring α-synuclein tetramers in blood may have potential as a facile biomarker assay for early detection and quantitative tracking of PD progression.
Neue Immunsuppressiva und das Risiko opportunistischer Infektionen
Authors: Reinhardt Fabian , von Braun Amrei , Trawinski Henning 
Published: June 2024

ZUSAMMENFASSUNGDie neuen therapeutischen Immunmodulatoren haben aufgrund ihres Wirkmechanismus unterschiedliche Infektionsrisiken. IL-1-Blockade erhöht vor allem das Risiko für bakterielle Infektionen. Die IL-5-hemmenden Substanzen bergen möglicherweise ein erhöhtes Risiko für Parasitosen. IL-6-Blockade führt zu einem erhöhten Risiko für schwere bakterielle und opportunistische Infektionen (OI), vergleichbar mit den TNF-α-Inhibitoren. Die IL-12/23-Blockade mit Ustekinumab zeigt wie auch der B-Lymphozyten-Stimulator (BLyS)-Inhibitor Belimumab im Vergleich mit anderen Therapeutika kein erhöhtes Infektionsrisiko. Unter einer IL-17-Hemmung ist vor allem mit gehäuften mukokutanen Kandidosen zu rechnen, insbesondere unter Bimekizumab. Der T-Zell-Aktivierungshemmer Abatacept erhöht das Risiko für Herpes Zoster (HZ), während andere Infektionen im Vergleich zu anderen Disease-Modifying Anti-Rheumatic Drugs (DMARD) sogar geringer sind. Auch Anifrolumab, ein Typ-1-Interferon-Inhibitor, erhöht das Risiko für HZ, aber auch für Atemwegsinfektionen. Beim Einsatz von Januskinase-Inhibitoren (JAKi) ist insbesondere mit HZ zu rechnen, wogegen andere OI seltener und in ihrer Häufigkeit mit den meisten älteren Biologika vergleichbar sind.
Vergleich der Therapie mit JAK-Inhibitoren bei der juvenilen idiopathischen Arthritis in der klinischen Praxis und in den Zulassungsstudien
Authors: Horneff Gerd , Windschall Daniel , Minden Kirsten , Kümmerle-Deschner Jasmin , Dressler Frank , Weller-Heinemann Frank , Foeldvari Ivan , Reiser Christiane , Klein Ariane 
Published: June 2024

ZUSAMMENFASSUNGDie juvenile idiopathische Arthritis (JIA) ist die häufigste chronisch-entzündliche rheumatische Erkrankung des Kindes- und Jugendalters. Mit der Einführung von Biologika konnte eine erhebliche Verbesserung von Prognose, Outcome und allgemeiner Lebensqualität erreicht werden, wobei ein schlechtes Ansprechen auf aktuelle Therapieoptionen bei einem Teil der Patienten die Notwendigkeit von alternativen Therapien unterstreicht. Mit der Zulassung von Januskinase-Inhibitoren, einer neuen Klasse von targeted synthetic Disease-Modifying Antirheumatic Drugs (DMARD), stehen Tofacitinib und Baricitinib aktuell als orale Therapiealternativen bei der JIA zur Verfügung. Erfahrungen aus Studien zur JIA sind begrenzt und können durch die Sammlung und Analyse von Daten aus der klinischen Praxis ergänzt werden. Auch diese sind bislang limitiert. Zur Auswertung stehen die ersten 65 Behandlungen mit Tofacitinib und 20 Patienten mit Baricitinib zur Verfügung. Trotz intensiver Vorbehandlung mit Biologika erreichten unter JAK-Inhibitoren bis zu 75 % der JIA-Patienten eine JADAS-definierte minimale Krankheitsaktivität und 50 % eine inaktive Erkrankung. 13 (20 %) Patienten der Tofacitinib-Kohorte und 1 (5 %) Patient der Baricitinib-Kohorte beendeten die Therapie aufgrund unzureichender Wirksamkeit. Die Verträglichkeit war gut, neue Sicherheitssignale konnten nicht beobachtet werden. Schwere oder opportunistische Infektionen oder thrombembolische Ereignisse wurden bislang nicht beobachtet. Nach den bisherigen limitierten Therapieerfahrungen stellen JAK-Inhibitoren eine bedeutsame Therapiealternative bei der JIA dar. Die Dokumentation wird fortgesetzt.
Electrosynthesis of Quinoxalines via Intermolecular Cyclization/Dehydrogenation of Ketones with o-Phenylenediamines
Authors: Liu Lei , Tao Yi , Zhang Jiahui , Hu Yangyang , Liu Huiying , Sun Jingwen 
Published: June 2024

AbstractIn this study, we proposed a novel electrochemical dehydrogenative synthetic method for preparing 2-substituted quinoxalines by intermolecular cyclization of aryl alkyl ketones and o-phenylenediamines. This method gave various quinoxalines in yields ranging from 35% to 71%. This novel protocol employs mild reaction conditions and offers moderate to excellent yields, a wide substrate scope, and broad functional-group compatibility. Furthermore, a late-stage functionalization and the wide substrate scope demonstrated the synthetic utility of this protocol.
Suturing and Closure of Diaphragma Sella to Augment Sellar Floor Repair after Endonasal Endoscopic Resection of Large Pituitary Adenoma
Authors: Sahoo Sushanta K. , Bethanbhatla Murali K. , Dhandapani Sivashanmugam 
Published: June 2024

Abstract
Background Large pituitary adenoma often pushes the diaphragma sella and extends to the suprasellar compartment. The thinned out diaphragma may get opened during endonasal endoscopic surgery and pose high risk for cerebrospinal fluid (CSF) leak. Such larger defects are difficult to plug with fat graft that tends to slip in to the subarachnoid space. Here, we describe a unique technique of closure of diaphragma sella that augment repair of the skull base in such cases.
Materials and Method The free edge of diaphragma sella was sutured with the anterior tuberculum sella dura in five cases of large pituitary adenoma that needed extra arachnoidal resection. Suturing was done with 6-0 prolene using endoscopic needle holder that converted a large diaphragm defect in to a smaller arachnoid rent and was easily plugged with fat graft.
Result None of these patients had postoperative CSF leak.
Conclusion Though technically difficult, direct repair of the diaphragma sella is possible. This augments the skull base reconstruct and effectively reduces the chances of postoperative CSF leak.
Prospects for Use of Botulinum Toxin Type A for Prevention of Hypertrophic and Keloid Scars after Surgeries
Authors: Korableva Natalia , Romanenkov Nikolay , Kremlev Dmitriy , Nekrasov Andrei , Miroshnichenko Maksim , Arbekov Peter 
Published: June 2024

Abstract
Objective To evaluate the possibility of improving and preventing the formation of postoperative hypertrophic and keloid scars using botulinum toxin type A (BTA).
Materials and Methods Scientific articles published in English have been systematically screened in PubMed/MEDLINE database over the entire period. The following information about the studies was analyzed: first author surname; year of publication; number of patients; average age; scar location; dosage of the drug administered; follow-up duration; scar assessment methods; results, incidence of hypertrophic and keloid scars formation. The odds ratio and 95% confidence interval were calculated for each of the estimated parameters. The statistical heterogeneity of publications assessed using the criteria of chi-square test and I
2. The differences were considered significant at p < 0.05.
Results A total of 18 prospective randomized studies were selected for evaluation, containing data on the use of BTA in 363 cases. Patients receiving botulinum toxin had a lower Vancouver scar scale index, higher visual analog scale index, and higher Stony Brook scar evaluation scale score. The use of BTA reduces the risk of perceptible scar formation, the incidence of hypertrophic and keloid scars.
Conclusion The use of BTA to obtain imperceptible scar and prevent hypertrophic and keloid postoperative scars demonstrates good prospects. However, there is no consensus regarding the pathophysiological mechanisms underlying the positive effect of BTA on the prevention of hypertrophic and keloid scars.