bluuebunny/crossref_metadata_2025_split huggingface dataset:
MPC‐based cooperative multiagent search for multiple targets using a Bayesian framework
Authors: Xiao Hu , Cui Rongxin , Xu Demin , Li Yanran 
Published: June 2024

AbstractThis paper presents a multiagent cooperative search algorithm for identifying an unknown number of targets. The objective is to determine a collection of observation points and corresponding safe paths for agents, which involves balancing the detection time and the number of targets searched. A Bayesian framework is used to update the local probability density function of the targets when the agents obtain information. We utilize model predictive control and establish utility functions based on the detection probability and decrease in information entropy. A target detection algorithm is implemented to verify the target based on minimum‐risk Bayesian decision‐making. Then, we improve the search algorithm with the target detection algorithm. Several simulations demonstrate that compared with other existing approaches, the proposed approach can reduce the time needed to detect targets and the number of targets searched. We establish an experimental platform with three unmanned aerial vehicles. The simulation and experimental results verify the satisfactory performance of our algorithm.
Self‐Assembly of Super‐Uniform Covalent Organic Framework Colloidal Particles into Multi‐Dimensional Ordered Superstructures
Authors: Ma Wende , Zhang Ning , Long Caicheng , Shu Zhao , Liu Yacong , Lin Yue , Lu Dawei , Liu Qian , Jiang Guibin 
Published: June 2024

AbstractPrecise self‐assembly of colloidal particles is crucial for understanding their aggregation properties and preparing macroscopic functional devices. It is currently very challenging to synthesize and self‐assemble super‐uniform covalent organic framework (COF) colloidal particles into well‐organized multidimensional superstructures. Here, simple and versatile strategies are proposed for synthesis of super‐uniform COF colloidal particles and self‐assembly of them into 1D supraparticles, 2D ordered mono/multilayers, and 3D COF films. For this purpose, several self‐assembly techniques are developed, including emulsion solvent evaporation, air‐liquid interfacial self‐assembly, and drop‐casting. These strategies enable the superstructural self‐assembly of particles of varying sizes and species without any additional surfactants or chemical modifications. The assembled superstructures maintain the porosity and high specific surface area of their building blocks. The feasibility of the strategies is examined with different types of COFs. This research provides a new approach for the controllable synthesis of super‐uniform COF colloidal particles capable of self‐assembling into multidimensional superstructures with long‐range order. These discoveries hold great promise for the design of emerging multifunctional COF superstructures.
1G6‐D7 Inhibits Homologous Recombination Repair by Targeting Extracellular HSP90α to Promote Apoptosis in Non–Small Cell Lung Cancer
Authors: Du Jiangzhou , Zhang Jinming , Liu Dongyu , Gao Lin , Liao Hua , Chu Lanhe , Lin Jie , Li Wei , Meng Xiaojing , Zou Fei , Cai Shaoxi , Zou Mengchen , Dong Hangming 
Published: June 2024

ABSTRACTDespite recent advances in treatment, non–small cell lung cancer (NSCLC) continues to have a high mortality rate. Currently, NSCLC pathogenesis requires further investigation, and therapeutic drugs are still under development. Homologous recombination repair (HRR) repairs severe DNA double‐strand breaks. Homologous recombination repair deficiency (HRD) occurs when HRR is impaired and causes irreparable double‐strand DNA damage, leading to genomic instability and increasing the risk of cancer development. Poly(ADP‐ribose) polymerase (PARP) inhibitors can effectively treat HRD‐positive tumors. Extracellular heat shock protein 90α (eHSP90α) is highly expressed in hypoxic environments and inhibits apoptosis, thereby increasing cellular tolerance. Here, we investigated the relationship between eHSP90α and HRR in NSCLC. DNA damage models were established in NSCLC cell lines (A549 and H1299). The activation of DNA damage and HRR markers, apoptosis, proliferation, and migration were investigated. In vivo tumor models were established using BALB/c nude mice and A549 cells. We found that human recombinant HSP90α stimulation further activated HRR and reduced DNA damage extent; however, eHSP90α monoclonal antibody, 1G6‐D7, effectively inhibited HRR. HRR inhibition and increased apoptosis were observed after LRP1 knockdown; this effect could not be reversed with hrHSP90α addition. The combined use of 1G6‐D7 and olaparib caused significant apoptosis and HRR inhibition in vitro and demonstrated promising anti‐tumor effects in vivo. Extracellular HSP90α may be involved in HRR in NSCLC through LRP1. The combined use of 1G6‐D7 and PARP inhibitors may exert anti‐tumor effects by inhibiting DNA repair and further inducing apoptosis of NSCLC cells.
Symmetry resolution in non-Lorentzian field theories
Authors: Banerjee Aritra , Basu Rudranil , Bhattacharyya Arpan , Chakrabarti Nilachal 
Published: June 2024

Abstract
Starting from the computation of Symmetry Resolved Entanglement Entropy (SREE) for boosted intervals in a two dimensional Conformal Field Theory, we compute the same in various non-Lorentzian limits, viz, Galilean and Carrollian Conformal Field Theory in same number of dimensions. We approach the problem both from a limiting perspective and by using intrinsic symmetries of respective non-Lorentzian conformal algebras. In particular, we calculate the leading order terms, logarithmic terms, and the $$ \mathcal{O}(1) $$
O

1

terms and explicitly show exact compliance with equipartition of entanglement, even in the non-Lorentzian system. Keeping in mind the holographic origin of SREE for the Carrollian limit, we further compute SREE for BMS3-Kac-Moody, which couples a U(1) × U(1) theory with bulk gravity.
Metric perturbations in noncommutative gravity
Authors: Herceg Nikola , Jurić Tajron , Samsarov Andjelo , Smolić Ivica 
Published: June 2024

Abstract
We use the framework of Hopf algebra and noncommutative differential geometry to build a noncommutative (NC) theory of gravity in a bottom-up approach. Noncommutativity is introduced via deformed Hopf algebra of diffeomorphisms by means of a Drinfeld twist. The final result of the construction is a general formalism for obtaining NC corrections to the classical theory of gravity for a wide class of deformations and a general background. This also includes a novel proposal for noncommutative Einstein manifold. Moreover, the general construction is applied to the case of a linearized gravitational perturbation theory to describe a NC deformation of the metric perturbations. We specifically present an example for the Schwarzschild background and axial perturbations, which gives rise to a generalization of the work by Regge and Wheeler. All calculations are performed up to first order in perturbation of the metric and noncommutativity parameter. The main result is the noncommutative Regge-Wheeler potential. Finally, we comment on some differences in properties between the Regge-Wheeler potential and its noncommutative counterpart.
Modularity in Argyres-Douglas theories with a = c
Authors: Jiang Hongliang 
Published: June 2024

Abstract
We consider a family of Argyres-Douglas theories, which are 4D $$ \mathcal{N} $$
N
= 2 strongly coupled superconformal field theories (SCFTs) but share many features with 4D $$ \mathcal{N} $$
N
= 4 super-Yang-Mills theories. In particular, the two central charges of these theories are the same, namely a = c. We derive a simple and illuminating formula for the Schur index of these theories, which factorizes into the product of a Casimir term and a term referred to as the Schur partition function. While the former is controlled by the anomaly, the latter is identified with the vacuum character of the corresponding chiral algebra and is expected to satisfy the modular linear differential equation. Our simple expression for the Schur partition function, which can be regarded as the generalization of MacMahon’s generalized sum-of-divisor function, allows one to numerically compute the series expansions efficiently, and furthermore find the corresponding modular linear differential equation. In a special case where the chiral algebra is known, we are able to derive the corresponding modular linear differential equation using Zhu’s recursion relation. We further study the solutions to the modular linear differential equations and discuss their modular transformations. As an application, we study the high temperature limit or the Cardy-like limit of the Schur index using its simple expression and modular properties, thus shedding light on the 1/4-BPS microstates of genuine $$ \mathcal{N} $$
N
= 2 SCFTs with a = c and their dual quantum gravity via the AdS/CFT correspondence.
HbA1c variability is independently associated with progression of diabetic kidney disease in an urban multi-ethnic cohort of people with type 1 diabetes
Authors: Muthukumar Ananya , Badawy Layla , Mangelis Anastasios , Vas Prashant , Thomas Stephen , Gouber Aicha , Ayis Salma , Karalliedde Janaka 
Published: June 2024

Abstract
Aims/hypothesis
The role of HbA1c variability in the progression of diabetic kidney disease is unclear, with most studies to date performed in White populations and limited data on its role in predicting advanced kidney outcomes. Our aim was to evaluate if long-term intra-individual HbA1c variability is a risk factor for kidney disease progression (defined as an eGFR decline of ≥50% from baseline with a final eGFR of <30 ml/min per 1.73 m2) in an ethnically heterogeneous cohort of people with type 1 diabetes with a preserved eGFR ≥45 ml/min per 1.73 m2 at baseline.

Methods
Electronic health record data from people attending outpatient clinics between 2004 and 2018 in two large university hospitals in London were collected. HbA1c variability was assessed using three distinct methods: (1) SD of HbA1c (SD-HbA1c); (2) visit-adjusted SD (adj-HbA1c): SD-HbA1c/√n/(n–1), where n is the number of HbA1c measurements per participant; and (3) CV (CV-HbA1c): SD-HbA1c/mean-HbA1c. All participants had six or more follow-up HbA1c measurements. The eGFR was measured using the Chronic Kidney Disease Epidemiology Collaboration equation and clinical/biochemical results from routine care were extracted from electronic health records.

Results
In total, 3466 participants (50% female, 78% White, 13% African Caribbean, 3% Asian and 6% of mixed heritage or self-reporting as ‘other’) were followed for a median (IQR) of 8.2 (4.2–11.6) years. Of this cohort, 249 (7%) showed kidney disease progression. Higher HbA1c variability was independently associated with a higher risk of kidney disease progression, with HRs (95% CIs) of 7.76 (4.54, 13.26), 2.62 (1.75, 3.94) and 5.46 (3.40, 8.79) (lowest vs highest HbA1c variability quartile) for methods 1–3, respectively. Increasing age, baseline HbA1c, systolic BP and urinary albumin/creatinine ratio were also associated with kidney disease progression (p<0.05 for all). African Caribbean ethnicity was associated with an increased risk of kidney disease progression (HR [95% CI] 1.47 [1.09, 1.98], 1.76 [1.32, 2.36] and 1.57 [1.17, 2.12] for methods 1–3, respectively) and this effect was independent of glycaemic variability and other traditional risk factors.

Conclusions/interpretation
We observed an independent association between HbA1c variability, evaluated using three distinct methods, and significant kidney disease progression in a multi-ethnic type 1 diabetes cohort. Further studies are needed to elucidate the mechanisms that may explain our results and evaluate if HbA1c variability is a modifiable risk factor for preventing diabetic kidney disease progression.

Graphical Abstract
The Decline of Paget’s Disease of Bone and Domestic Coal Use—A Hypothesis
Authors: Cundy Tim 
Published: June 2024

AbstractThe cause of Paget’s disease of bone (PDB) is unknown. It emerged as a distinct entity in Britain in the late nineteenth century when it was prevalent, and florid presentation not uncommon. Epidemiological surveys in the 1970s showed that Britain had a substantially higher prevalence of PDB than any other country. Studies in the late twentieth and early twenty-first centuries have documented an unexplained change in presentation, with a greatly reduced prevalence and less severe disease than formerly. The emergence of PDB in Britain coincided with rapid industrialization which, in turn, was driven by the use of coal for energy. In the home, bituminous coal was customarily burnt on an open hearth for heating. Using data on coal production, population size, and estimates of domestic use, the estimated exposure to domestic coal burning rose threefold in Britain during the nineteenth century and began to fall after 1900. This pattern fits well with the decline in PDB documented from death certification and prevalence surveys. Colonists moving from Britain to North America, Australia and New Zealand established coal mines and also used coal for domestic heating. PDB was found in these settler populations, but was largely absent from people indigenous to these lands. In all parts of the world PDB prevalence has fallen as the burning of coal in open hearths for domestic heating has reduced. The nature of the putative factor in coal that could initiate PDB is unknown, but possible candidates include both organic and inorganic constituents of bituminous coal.
A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology
Authors: Cerron-Vela Carmen Rosa , Gonçalves Fabrício Guimarães , Tierradentro-García Luis Octavio , Viaene Angela N , Lerebo Wondwossen , Andronikou Savvas 
Published: June 2024

Abstract
Purpose
Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs.

Methods
This single-center, retrospective study included patients <21 years of age with preoperative spinal MRI and confirmed pathological diagnosis of PSG from 2000-2022. Tumors were classified using the 5th edition of the WHO CNS Tumors Classification. Two radiologists reviewed multiple imaging features, and classified enhancement patterns using a novel approach. Fisher's exact test determined associations between imaging and histological features.

Results
Forty-one PSGs were reviewed. Thirty-four were intramedullary, and seven were extramedullary. Pilocytic astrocytoma was the most common tumor (39.02%). Pain and weakness were the most prevalent symptoms. Seven patients (17.07%) died. Cyst, syringomyelia, and leptomeningeal enhancement were associated with tumor grade. Widening of the spinal canal was observed only in low-grade astrocytomas. There was a significant association between tumor grade and contrast enhancement pattern. Specifically, low-grade PSGs were more likely to exhibit type 1A enhancement (mass-like, with well-defined enhancing margins) and less likely to exhibit type 1B enhancement (mass-like, with ill-defined enhancing margins).

Conclusion
PSGs display overlapping imaging features, making grade differentiation challenging based solely on imaging. The correlation between tumor grade and contrast enhancement patterns suggests a potential diagnostic avenue, requiring further validation with larger, multicenter studies. Furthermore, Low-grade PSGs display cysts and syringomyelia more frequently, and leptomeningeal enhancement is less common.
Temporal variations of bacterial and eukaryotic community in coastal waters—implications for aquaculture
Authors: Sun Fulin , Wang Chunzhong , Xu Zhantang , Song Xingyu , Cui Haiping , Wang Zhen , Ouyang Zhiyuan , Fu Xiaoming 
Published: June 2024

Abstract
Despite increased attention to the aquaculture environment, there is still a lack of understanding regarding the significance of water quality. To address this knowledge gap, this study utilized high-throughput sequencing of 16S rRNA and 18S rRNA to examine microbial communities (bacteria and eukaryotes) in coastal water over different months through long-term observations. The goal was to explore interaction patterns in the microbial community and identify potential pathogenic bacteria and red tide organisms. The results revealed significant differences in composition, diversity, and richness of bacterial and eukaryotic operational taxonomic units (OTUs) across various months. Principal coordinate analysis (PCoA) demonstrated distinct temporal variations in bacterial and eukaryotic communities, with significant differences (P = 0.001) among four groups: F (January-April), M (May), S (June–September), and T (October-December). Moreover, a strong association was observed between microbial communities and months, with most OTUs showing a distinct temporal preference. The Kruskal–Wallis test (P < 0.05) indicated significant differences in dominant bacterial and eukaryotic taxa among months, with each group exhibiting unique dominant taxa, including potential pathogenic bacteria and red tide organisms. These findings emphasize the importance of monitoring changes in potentially harmful microorganisms in aquaculture. Network analysis highlighted positive correlations between bacteria and eukaryotes, with bacteria playing a key role in network interactions. The key bacterial genera associated with other microorganisms varied significantly (P < 0.05) across different groups. In summary, this study deepens the understanding of aquaculture water quality and offers valuable insights for maintaining healthy aquaculture practices.

Key points
• Bacterial and eukaryotic communities displayed distinct temporal variations.
• Different months exhibited unique potential pathogenic bacteria and red tide organisms.
• Bacteria are key taxonomic taxa involved in microbial network interactions.
Chidamide combined with a modified Bu-Cy conditioning regimen improves survival in patients with T-cell acute lymphoblastic leukemia/lymphoma undergoing allogeneic hematopoietic stem cell transplantation
Authors: Cao Xuanqi , Li Zheng , Zhang Yanming , Cui Qingya , Dai Haiping , Ma Yunju , Li Mengyun , Chen Sifan , Yin Jia , Cui Wei , Chen Jia , Sun Aining , Qiu Huiying , Chen Suning , Zhu Xiaming , Andersson Borje S. , Wu Depei , Tang Xiaowen 
Published: June 2024

AbstractThis study aimed to evaluate the efficacy and safety of chidamide (Chi) combined with a modified Busulfan-Cyclophosphamide (mBuCy) conditioning regimen for T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Twenty-two patients received chidamide combined with mBuCy conditioning regimen (Chi group). A matched-pair control (CON) group of 44 patients (matched 1:2) received mBuCy only in the same period. The leukemia-free survival (LFS), overall survival (OS), cumulative incidence of relapse (CIR), and non-relapse-related mortality (NRM) were evaluated. Patients in the Chi group were associated with lower 2-year CIR (19.0 vs. 41.4%, P = 0.030), better 2-year LFS (76.1 vs. 48.1%, P = 0.014), and had no significant difference in 2-year OS (80.5 vs. 66.4%, P = 0.088). Patients with minimal residual disease (MRD) positive before HSCT in the Chi group exhibited an advantage in 2-year LFS and a trend towards better 2-year OS (75.0 vs. 10.2%, P = 0.048; 75.0 vs. 11.4%, P = 0.060, respectively). Multivariable analysis showed that the chidamide intensified regimen was independently associated with better LFS (HR 0.23; 95%CI, 0.08–0.63; P = 0.004), and showed no significant impact with OS for all patients (HR 0.34, 95%CI, 0.11–1.07; P = 0.064). The cumulative incidence rates of grade II-IV aGVHD were similar (36.4 vs. 38.6%, P = 0.858). 20 patients in Chi group evinced an elevation in γ-glutamyltransferase, as compared to the mBuCy group (90.9 vs. 65.9%, P = 0.029). No transplantation-related mortality was documented within the first 100 days after transplantation. The results demonstrate that the chidamide intensified regimen may be an effective and acceptable safety option for T-ALL/LBL undergoing allo-HSCT, and further validation is needed.
Lesions hyper- to isointense to surrounding liver in the hepatobiliary phase of gadoxetic acid-enhanced MRI
Authors: Furumaya Alicia , Willemssen François E. J. A. , Miclea Razvan L. , Haring Martijn P. D. , de Haas Robbert J. , Feshtali Shirin , Vanhooymissen Inge J. S. , Bos Daniel , de Man Robert A. , Ijzermans Jan N. M. , Erdmann Joris I. , Verheij Joanne , Doukas Michail C. , van Delden Otto M. , Thomeer Maarten G. J. 
Published: June 2024

Abstract
Objectives
Hyper- or isointensity in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI has high specificity for focal nodular hyperplasia (FNH) but may be present in hepatocellular adenoma and carcinoma (HCA/HCC). This study aimed to identify imaging characteristics differentiating FNH and HCA/HCC.

Materials and methods
This multicenter retrospective cohort study included patients with pathology-proven FNH or HCA/HCC, hyper-/isointense in the HBP of gadoxetic acid-enhanced MRI between 2010 and 2020. Diagnostic performance of imaging characteristics for the differentiation between FNH and HCA/HCC were reported. Univariable analyses, multivariable logistic regression analyses, and classification and regression tree (CART) analyses were conducted. Sensitivity analyses evaluated imaging characteristics of B-catenin-activated HCA.

Results
In total, 124 patients (mean age 40 years, standard deviation 10 years, 108 female) with 128 hyper-/isointense lesions were included. Pathology diagnoses were FNH and HCA/HCC in 64 lesions (50%) and HCA/HCC in 64 lesions (50%). Imaging characteristics observed exclusively in HCA/HCC were raster and atoll fingerprint patterns in the HBP, sinusoidal dilatation on T2-w, hemosiderin, T1-w in-phase hyperintensity, venous washout, and nodule-in-nodule partification in the HBP and T2-w. Multivariable logistic regression and CART additionally found a T2-w scar indicating FNH, less than 50% fat, and a spherical contour indicating HCA/HCC. In our selected cohort, 14/48 (29%) of HCA were B-catenin activated, most (13/14) showed extensive hyper-/isointensity, and some had a T2-w scar (4/14, 29%).

Conclusion
If the aforementioned characteristics typical for HCA/HCC are encountered in lesions extensively hyper- to isointense, further investigation may be warranted to exclude B-catenin-activated HCA.

Clinical relevance
Hyper- or isointensity in the HBP of gadoxetic acid-enhanced MRI is specific for FNH, but HCA/HCC can also exhibit this feature. Therefore, we described imaging patterns to differentiate these entities.

Key Points

FNH and HCA/HCC have similar HBP intensities but have different malignant potentials.

Six imaging patterns exclusive to HCA/HCC were identified in this lesion population.

These features in liver lesions hyper- to isointense in the HBP warrant further evaluation.