bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scalp Cooling in Preventing Persistent Chemotherapy-Induced Alopecia: A Randomized Controlled Trial
Authors: Kang Danbee , Cho Juhee , Zhao Di , Kim Jeonghyun , Kim Nayeon , Kim Hoyoung , Kim Sooyeon , Kim Ji-Yeon , Park Yeon Hee , Im Young Hyuck , Guallar Eliseo , Ahn Jin Seok 
Published: June 2024

PURPOSE Current studies of the efficacy of scalp cooling are limited by short-term duration. Therefore, we conducted a randomized controlled trial to evaluate the efficacy of scalp cooling in reducing persistent chemotherapy-induced alopecia (PCIA) 6 months after chemotherapy. METHODS We conducted an open-label randomized controlled trial comparing scalp cooling versus control in newly diagnosed patients with breast cancer stages I-III scheduled to receive neoadjuvant or adjuvant chemotherapy with curative intent between December 2020 and August 2021. Patients were randomly assigned (2:1 ratio) to scalp cooling or usual clinical practice. The primary outcome was PCIA 6 months after chemotherapy. Hair thickness and density were measured using Folliscope 5.0. CIA-related distress was assessed using the CIA distress scale (CADS), with a higher score reflecting higher stress. RESULTS The proportion of patients with PCIA at 6 months was 13.5% (12/89) in the scalp-cooling group and 52.0% (26/50) in the control group. The average difference in the change in hair thickness from baseline between the scalp-cooling and control groups was 9.0 μm in favor of the intervention group. The average difference in the change in hair density between intervention and control at the end of the study was –3.3 hairs/cm2. At 6 months after chemotherapy, the average difference in the change in CADS score between the intervention and control groups was –3.2 points, reflecting reduced CIA-related stress in the intervention group. CONCLUSION Scalp cooling reduced the incidence of PCIA, primarily by increasing hair thickness compared with control. Scalp cooling is helpful in promoting qualitative hair regrowth. Yet, further research is necessary to observe longer-term benefits of scalp cooling.
Diagnostic Accuracy of Vascular Ultrasonography for Postanesthesia Induction Hypotension: A Systematic Review and Network Meta-Analysis
Authors: Schorer Raoul , Ibsen Arni , Hagerman Andres , Ellenberger Christoph , Putzu Alessandro 
Published: June 2024

BACKGROUND:
Arterial hypotension commonly occurs after anesthesia induction and is associated with negative clinical outcomes. Point-of-care ultrasound examination has emerged as a modality to predict postinduction hypotension (PIH). We performed a systematic review and network meta-analysis of the predictive performance of point-of-care ultrasound tests for PIH in noncardiac, nonobstetrical routine adult surgery.

METHODS:
Online databases were searched for diagnostic test accuracy studies of point-of-care ultrasound for predicting PIH up to March 30, 2023. The systematic review followed the Cochrane methodology. A Bayesian diagnostic test accuracy network meta-analysis model was used, with PIH as defined by study authors as the main outcome. Risk of bias and applicability were examined through the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies) score. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework was used to assess evidence certainty.

RESULTS:
A total of 32 studies with 2631 participants were eligible for systematic review. Twenty-six studies with 2258 participants representing 8 ultrasound tests were included in the meta-analysis. Inferior vena cava collapsibility index (22 studies) sensitivity was 60% (95% credible interval [CrI], 49%–72%) and specificity was 83% (CrI, 74%–89%). Carotid artery corrected flow time (2 studies) sensitivity was 91% (CrI, 76%–98%) and specificity was 90% (CrI, 59%–98%). There were serious bias and applicability concerns due to selection bias and inappropriate blinding. The certainty of evidence was very low for all tests.

CONCLUSIONS:
The predictive performance of point-of-care ultrasound for PIH is uncertain. There is a need for high-quality randomized controlled trials with appropriate blinding and void of selection bias.
Avant-Garde Anachronism
Authors: Chen Fangdai 
Published: June 2024

Abstract
This article examines Chen Chuncheng, an up-and-coming mainland Chinese novelist emerging from the internet, as a representative case of a renewed manifestation of literary avant-gardism in the contemporary Sinosphere. It is an avant-gardism that challenges the status quo of the avant-garde's radical revolutionism and shields itself under a more sophisticated and adaptable aestheticism. In engaging with China's classical past, particularly in his imagined history of Dream of the Red Chamber in a fictitious forty-ninth century where futuristic digital motifs abound, the young novelist invokes the radical belief in the power of wen 文 (letters) to intervene in sociopolitical crises. It is a belief that aligns with the avant-garde's core spirit of coming to the rescue of a society through aesthetic means. In deconstructing the temporality and materiality of literary texts, Chen also enacts a meta-reflection on the existential condition of literature in cyberspace, where digital technologies make it possible for literary productions to take alternative forms, to roam around, and to dissolve when the exigency of socio-historical circumstances necessitates. The digital world therefore constitutes the most ideal site to host literature's omni-presence and omni-absence—two concepts that form the dialectical kernel of Chen Chuncheng's neo-avant-gardism.
CEP41, a ciliopathy-linked centrosomal protein, regulates microtubule assembly and cell proliferation
Authors: Prassanawar Shweta Shyam , Sarkar Tuhin , Panda Dulal 
Published: June 2024

ABSTRACT
Centrosomal proteins play pivotal roles in orchestrating microtubule dynamics, and their dysregulation leads to disorders, including cancer and ciliopathies. Understanding the multifaceted roles of centrosomal proteins is vital to comprehend their involvement in disease development. Here, we report novel cellular functions of CEP41, a centrosomal and ciliary protein implicated in Joubert syndrome. We show that CEP41 is an essential microtubule-associated protein with microtubule-stabilizing activity. Purified CEP41 binds to preformed microtubules, promotes microtubule nucleation and suppresses microtubule disassembly. When overexpressed in cultured cells, CEP41 localizes to microtubules and promotes microtubule bundling. Conversely, shRNA-mediated knockdown of CEP41 disrupts the interphase microtubule network and delays microtubule reassembly, emphasizing its role in microtubule organization. Further, we demonstrate that the association of CEP41 with microtubules relies on its conserved rhodanese homology domain (RHOD) and the N-terminal region. Interestingly, a disease-causing mutation in the RHOD domain impairs CEP41–microtubule interaction. Moreover, depletion of CEP41 inhibits cell proliferation and disrupts cell cycle progression, suggesting its potential involvement in cell cycle regulation. These insights into the cellular functions of CEP41 hold promise for unraveling the impact of its mutations in ciliopathies.
Dynamic Usage Allocation and Pricing for Curb Space Operation
Authors: Lim Jisoon , Masoud Neda 
Published: June 2024

The importance of curbside management is quickly growing in a modernized urban setting. Dynamic allocation of curb space to different usages and dynamic pricing for those usages can help meet the growing demand for curb space more effectively and promote user turnover. To model curbside operations, we formulate a Stackelberg leader-follower game between a leader operating curbside spaces, who sets space allocation and pricing of each curbside usage, and multi-followers, one for each type of curbside usage, who accept the proposed prices or reject them in favor of outside options. The proposed model offers flexible adaptability to manage curb space usages characterized by high turnover rates, such as parking and ride-sourcing pickup and drop-off, alongside accommodating usages that require more permanent infrastructure allocation, such as micromobility stations. Furthermore, the proposed model is able to capture the sensitivity of users to both prices, which are determined solely by the operator, and the occupancy levels of the curb space, which are determined by the complex interactions between the curbside operator and the users. We model a Stackelberg leader-follower game as a bilevel nonlinear optimization problem and reconstruct the problem into a single-level convex program by applying the Karush-Kuhn-Tucker conditions, objective function transformation, and constraint linearization. Then, we develop a solution algorithm that leverages valid inequalities produced via Benders decomposition. We validate the practicability of the model and draw insights into curbside management using numerical experiments. History: This paper has been accepted for the Transportation Sci. Special Issue on the ISTTT25 Conference. Funding: This work was supported by the National Science Foundation, Division of Civil, Mechanical and Manufacturing Innovation [Grant 2046372]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2024.0507 .
Very early vs delayed invasive strategy in high-risk NSTEMI patients without hemodynamic instability: Insight from the KAMIR-NIH
Authors: Lee Seung Do , Kim Rock Bum , Seo Chang-Ok , Kim Moojun , Lee Hyo Jin , Kim Hangyul , Kim Hye Ree , Kim Kyehwan , Kang Min Gyu , Park Jeong Rang , Hwang Suk Jae , Hwang Jin Yong , Jeong Myung Ho , Hur Seung-Ho , Cha Kwang Soo , Koh Jin-Sin ,   on behalf of the KAMIR-NIH registry investigators
Published: June 2024

Background
High-risk non-ST-elevation myocardial infarction (NSTEMI) patients’ optimal timing for percutaneous coronary intervention (PCI) is debated despite the recommendation for early invasive revascularization. This study aimed to compare outcomes of NSTEMI patients without hemodynamic instability undergoing very early invasive strategy (VEIS, ≤ 12 hours) versus delayed invasive strategy (DIS, >12 hours).

Methods
Excluding urgent indications for PCI including initial systolic blood pressure under 90 mmHg, ventricular arrhythmia, or Killip class IV, 4,733 NSTEMI patients were recruited from the Korea Acute Myocardial Infarction Registry-National Institutes of Health (KAMIR-NIH). Patients were divided into low and high- global registry of acute coronary events risk score risk score (GRS) groups based on 140. Both groups were then categorized into VEIS and DIS. Clinical outcomes, including all-cause death (ACD), cardiac death (CD), recurrent MI, and cerebrovascular accident at 12 months, were evaluated.

Results
Among 4,733 NSTEMI patients, 62% had low GRS, and 38% had high GRS. The proportions of VEIS and DIS were 43% vs. 57% in the low GRS group and 47% vs. 53% in the high GRS group. In the low GRS group, VEIS and DIS demonstrated similar outcomes; however, in the high GRS group, VEIS exhibited worse ACD outcomes compared to DIS (HR = 1.46, P = 0.003). The adverse effect of VEIS was consistent with propensity score matched analysis (HR = 1.34, P = 0.042).

Conclusion
VEIS yielded worse outcomes than DIS in high-risk NSTEMI patients without hemodynamic instability in real-world practice.
Preparation of biomass activated carbon with aligned graphene nanosheet arrays from bamboo parenchymal cells for supercapacitors
Authors: Xia Yao , Liu Zhigao , Huang Yuxiang 
Published: June 2024

Abstract
The increasing recognition of the need for economically viable carbon materials in supercapacitors has resulted in a notable emphasis on utilizing recycled biomass waste as a precursor for activated carbon (AC). This study investigates the production of highly porous AC through vertically aligned graphene nanosheet arrays (VAGNAs) derived from bamboo parenchyma cells, a type of biomass waste. The focus lies in manipulating the ratio of alkali to carbon during the activation process. Elevating the alkali-carbon ratio augments the specific surface area of the AC while concurrently reducing the presence of VAGNAs. Surprisingly, AC generated with an alkali-carbon ratio of four exhibits a remarkable specific capacitance of 215 F g−1 when subjected to a current density of 0.2 A g−1. When integrated into a supercapacitor apparatus, this AC material demonstrates a notable energy density of 11.2 W-hours per kilogram (Wh kg−1) at a power density of 50 W per kilogram (W kg−1). Moreover, it displays exceptional cycling stability, maintaining 89.4 % of its capacitance after undergoing 10,000 cycles in a 6 M potassium hydroxide electrolyte. The findings of this investigation underscore the potential of utilizing waste bamboo parenchyma cells for sustainable energy storage applications.
“Laughing with” or “laughing at” people with disabilities? Love on the Spectrum and Derek
Authors: Kulick Don 
Published: June 2024

Abstract
This paper explores the charged line between “laughing with” and “laughing at” people with disabilities. It documents how “the line” is structured, how the line between “laughing with” and “laughing at” is manifested, and how we might reasonably surmise when it has been crossed. Two television series are examined and compared. The first, Love on the Spectrum, is an Australian reality series that follows a number of young adults on the autism spectrum, as they search for love and go on dates with others who also are on the spectrum. Much of the charm of the series is that it evokes laughter, frequently at the seriousness of the people it portrays. The laughter raised during Love on the Spectrum is compared with the laughter encouraged by British comedian Ricky Gervais’s 2012–2014 series Derek, which is about a character who many viewers identified as being on the autism spectrum. The paper discusses similarities between the two series, but concludes by proposing that the laughter invited by the protagonists’ seriousness during these two series in fact is structured very differently.
Wenn Dinge Höflichkeit machen. Erzählter Austausch von Gegenständen in Heinrichs von Veldeke Eneas
Authors: Reicher Ruth 
Published: June 2024

Abstract
Discourses of courtliness manifest themselves, among other things, in medieval literature through a nuanced material culture. The paper substantiates this assumption through a comparison of two episodes in Heinrich von Veldeke’s Eneasroman, in which gifts are circulated and protagonists communicate nonverbally through acts of giving. Gifts, as communication media, appear predisposed to establish and preserve courtliness as objects of materialized politeness, guarding against potential loss of face. Gifts thus have agency, as they appear to initiate and determine actions.
(Miss-)verstandene Höflichkeitsformen: Zu Kulturkontakten zwischen Europa und der ‚Neuen Welt‘ im 16. Jahrhundert
Authors: Bastert Bernd 
Published: June 2024

Abstract
Using examples from some 16th century German and Spanish reports dealing with negotiations between indigenous peoples and Spanish conquerors in Latin America, the article describes transcultural forms of communication between these very different cultures. It can be stated that politeness certainly played a role in the initial decades of contact. However, as far as we can reconstruct from the texts, which have been reformed from a European perspective, it appears that politeness did not significantly contribute, especially not to a better understanding between the cultures.
Transient cold-front-water through y-shaped aluminium ducts: nature of turbulence, non-equilibrium thermodynamics, and velocity at the converged and diverged outlets
Authors: Wang Fuzhang , Animasaun Isaac Lare , Al Shamsi Dalal Matar , Muhammad Taseer , Ali Asgar 
Published: June 2024

Abstract
The interaction between water motion efficiency, outlet control mechanisms, and energy dynamics management hinges significantly on turbulence characteristics. However, understanding the influence of input velocities and duct features on outlets remains elusive. This study employs the realizable k − ɛ viscous model and Reynolds-averaged Navier–Stokes equations (RANS equations) to explore transient water dynamics encountering a cold front through ducts leading to convergence or divergence. Using Ansys Fluent 2023R2 and the waterlight workflow, meticulous meshing of the ducts is executed to capture flow intricacies accurately. Grid independence, suitable boundary conditions, and solver settings are carefully considered to ensure reliable results for investigating four key research questions. Duct bending introduces non-uniformities in velocity distribution, impacting exit velocity and altering flow characteristics and turbulence. In Case III, centrifugal forces from a 90° bend result in higher outlet velocities at the convergent exit and secondary flow patterns like swirls and vortexes. Additionally, entrance velocities influence Reynolds numbers, affecting mixing, heat transfer coefficients, and flow regimes, thereby optimizing thermal conductivity. This comprehensive investigation sheds light on optimizing water dynamics and energy management across various duct configurations, offering valuable insights into efficient flow control and thermal performance enhancement.
Large-scale photonic inverse design: computational challenges and breakthroughs
Authors: Kang Chanik , Park Chaejin , Lee Myunghoo , Kang Joonho , Jang Min Seok , Chung Haejun 
Published: June 2024

Abstract
Recent advancements in inverse design approaches, exemplified by their large-scale optimization of all geometrical degrees of freedom, have provided a significant paradigm shift in photonic design. However, these innovative strategies still require full-wave Maxwell solutions to compute the gradients concerning the desired figure of merit, imposing, prohibitive computational demands on conventional computing platforms. This review analyzes the computational challenges associated with the design of large-scale photonic structures. It delves into the adequacy of various electromagnetic solvers for large-scale designs, from conventional to neural network-based solvers, and discusses their suitability and limitations. Furthermore, this review evaluates the research on optimization techniques, analyzes their advantages and disadvantages in large-scale applications, and sheds light on cutting-edge studies that combine neural networks with inverse design for large-scale applications. Through this comprehensive examination, this review aims to provide insights into navigating the landscape of large-scale design and advocate for strategic advancements in optimization methods, solver selection, and the integration of neural networks to overcome computational barriers, thereby guiding future advancements in large-scale photonic design.
Publishing Embargoes and Versions of Preprints: Impact on the Dissemination of Information
Authors: Teixeira da Silva Jaime A. , Huang Chun-Kai (Karl) , Nazarovets Maryna 
Published: June 2024

Abstract
This commentary abridges three closely related aspects of scholarly publishing, copyright transfer to publishers in the subscription-based model, posting of author-accepted versions to preprint servers, and publishing embargoes, to appreciate how each might impact the dissemination of information. We found no direct evidence showing that either copyright transfer or the posting of early (i.e., author-submitted or journal-accepted) versions of works to preprint servers stifle academics’ ability to share their papers openly. However, some key structural issues and incompatibilities in policies may dampen the wider adoption of preprints despite their widely promoted advantages for scientists. We found a 6- to 36-month embargo period in place by 10 of the world’s top largest publishers, depending on the version of the record. These embargoes may constrain the dissemination of knowledge.
Scientific Testability Following the Assumption of Insufficient Knowledge and Resources
Authors: López-Astorga Miguel 
Published: June 2024

Abstract
Carnap described ways to test scientific hypotheses. However, Carnap acknowledged that confirmation can never be definite. This left open the issue about the criteria to accept hypotheses. On the other hand, Wang has developed a computer program working without sufficient knowledge or resources, which makes the action of the program akin to the manner the human mind thinks. Wang’s program includes quantitative indicators that can be assigned to the frequency and the confidence of sentences. The present paper tries to link both approaches. The goal is to show how quantitative indicators such as those in Wang’s program can also be attributed to scientific hypotheses. Those indicators can help make decisions about the acceptance of the hypotheses. All of this allows proposing general characteristics for a possible algorithm to decide whether a particular hypothesis is admissible.
Introduction
Authors: Kelly Orla , Givens Jennifer 
Published: June 2024

The intensifying global environmental crisis poses an existential threat to human well-being, exposing the deep vulnerabilities of our socio-economic systems and disproportionately burdening the world's most disadvantaged populations. A rich and long-standing tradition in macro-sociology offers a powerful lens to understand the underlying social drivers of this crisis. By examining the interconnectedness of development, well-being, and the environment this scholarship illuminates potential pathways towards a more sustainable future. The contributions in this special issue of leverages this macro-comparative approach and innovative multi-scalar quantitative methodologies to highlight these interdependencies, illustrating how structural inequality shapes human and environmental relations and how macroeconomic factors in some national contexts can hamper the pursuit of well-being in others.
We introduce the issue by providing context for the crisis and reviewing relevant theory and empirical research within the macro-sociological tradition. Subsequently, we showcase the contributions of each included paper, highlighting their unique insights and policy implications for structural reforms. Finally, we synthesize concrete policy recommendations and identify promising avenues for future research.