bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeted Synovial Fluid Proteomics for Biomarker Discovery in Rheumatoid Arthritis
Authors: Cano Leticia , Arkfeld Daniel G. 
Published: May 2009

AbstractObjectiveRheumatoid arthritis (RA) is an autoimmune disease that targets the synovium. The autoantigens involved in the autoantibody responses in RA are unknown. A targeted proteomics approach was used to identify proteins in RA synovial fluid (SF) that are recognized by autoantibodies in RA sera.MethodsRA SF, depleted of abundant proteins, was fractionated by two-dimensional liquid chromatography (chromatofocusing followed by reverse phase HPLC). Protein arrays constructed from these fractions were probed with RA and normal control sera, and proteins within reactive fractions were identified by mass spectrometry. The reactivity of RA sera to an identified peptide was confirmed by ELISA.ResultsRA sera specifically reacted to a SF fraction containing fibrin. Mass spectrometry analyses established the presence of a citrullinated arginine at position 271 of the fibrin fragment present in RA SF. A synthetic peptide corresponding to fibrin residues 259–287, containing the citrulline substitution at Arg 271, was recognized by 10 of 12 RA sera, but by two of 18 normal control sera and one of 10 systemic lupus erythematosus sera.ConclusionProteomics methodology can be used to directly characterize post-translational modifications in candidate autoantigens isolated from sites of disease activity. The finding that RA sera contain antibodies to the citrullinated fibrin 259–287 peptide may ultimately lead to improved diagnostic tests for RA and/or biomarkers for disease activity.
Temperature monitoring in Bakchar bog (West Siberia)
Authors: Dyukarev E.A. , Golovatskaya E.A. , Duchkov A.D. , Kazantsev S.A. 
Published: May 2009

Abstract
We report the results of continuous temperature monitoring (812 days, from 28 June 2005 to 26 September 2007) in a 80 cm layer of peat soil in Bakchar bog (West Siberia), at sampling rates of 60 min in wintertime and 15 min in summertime. Both annual and daily temperature patterns are controlled by water table position and weather conditions. Wintertime soil temperature patterns are disturbed by the formation of a seasonal frozen layer with its thickness (freezing depth) depending on the time when steady snow cover sets up and on soil moisture. During the period of frozen layer thawing, the temperature of peat becomes sensitive to peat moisture and water table position as well as to the air and peat surface temperature. The warm-season soil temperature patterns bear effects of peat warming by rainwater percolation, both in nightand daytime. The patterns with soil warming during rainfall and phase change during seasonal freezing-thawing cycles record disturbances to conductive heat transfer.
The United Nations: Then and Now
Authors: Finkelstein Lawrence S. 
Published: May 2009

“We do not want to entrust to five great Powers or to two great Powers the task of deciding … what our common destiny will be…”.To anyone who attended the great assemblage gathered at San Francisco in 1945 to write the Charter for the United Nations, these words have a familiar ring. Indeed, they might have been uttered (and no doubt were ad nauseam) by small-power representatives during the seemingly interminable debates over the rule of unanimity—the veto—in the Security Council. In fact, these words were spoken in February 1965 by the Mauritanian delegate explaining, on the final day of the “abortive” nineteenth session of the General Assembly, why he voted with Albania in protest against the “basis of consensus” which had governed the session.
Regional Development Financing
Authors: Bloch Henry Simon 
Published: May 2009

Regional development banks can serve as focal points for regional and subregional cooperation, thus promoting economic integration. They are institutions whose objectives are neither national nor global and whose leadership and staffs have a regional outlook.The first and immediate challenge confronting these regional development banks is the financing of regional projects which are beyond the reach of national development banks. The International Bank for Reconstruction and Development (IBRD) has devoted only limited resources to such project, with a few spectacular exceptions, especially the Indus River project. A purely national approach to planning and financing development does not make sense in most of Latin America and Africa because many nations on these continents are “minicountries,” too small to form economic units of development. Many national borders have been determined by political and diplomatic history rather than by economic factors; frequently, they cut across natural development units such as river basins or mineral deposits. Moreover, except in Europe, the very dearth of strong national institutions makes regional development banks important; they provide additional financial intermediaries to be interposed between the developing regions and the world financial centers, as well as between various national financial institutions of the member countries of the regions concerned.
Public Opinion and Regional Integration
Authors: Inglehart Ronald 
Published: May 2009

For the time being, at least, survey data is relevant to the study of regional integration chiefly insofar as it gives an indication of the influence of the public (and various elite groups) on the decisions of the respective national governments—and vice versa. As integration progresses in given regions our focus may change, and we may become primarily interested in the degree to which given groups direct support or demands toward supranational institutions. But for the present the basic question seems to be:To what extent do public preferences constitute an effective influence on a given set of national decisionmakers, encouraging them to make decisions which increase (or diminish) regional integration?
The expansion of West German capital and the founding of Euratom
Authors: Deubner Christian 
Published: May 2009

In the mid 1950s, West German industry changed from being oriented primarily towards internal and West European reconstruction needs and the supply of coal and steel, to being more oriented towards the international market of finished goods. Whereas prewar and war-time technology had dominated production processes and products up until then, U.S. competition started to force advanced technologies like computers and atomic energy upon industry.Along with increased instability in the general political and economic situation of West Germany these changes contributed greatly to progressive differentiation within what had been a more homogenous industry structure and within the West German state apparatus.One important result of these new trends was the genesis of a foreign atomic policy, resulting in the founding of Euratom. Global versus European orientation, traditional versus “modern” industries, traditional liberal versus new interventionalist policies were joined in the issue and produced a highly ambivalent result. In the attempt to explain and interpret the case of Euratom in this context, theories of integration and of state are tested. The greatest explanatory power is conceded to modern Marxist theories which combine the concept of international dependency with a differentiated concept of relations between state and industry.
Socialization of permanent representatives in the United Nations: some evidence
Authors: Peck Richard 
Published: May 2009

Cross-sectional evidence from interviews at the United Nations found some delegate socialization. Third World delegates with longer tenure showed frustration with the organization, expansionist interests toward its economic activities, and satisfaction with their governments' missions to the United Nations, suggesting increased identification with governmental supranationalist goals. Western delegates with longer tenure showed cynicism about world politics, frustration with the United Nations, expansionist interest toward the Secretariat, and dissatisfaction with their UN missions, suggesting tension between governmental policies and socialized delegate supranationalism which delegates may reduce by leaving the United Nations. Such socialization implies little more than a reinforcement of national policies.The finding of even this disheartening socialization in the United Nations calls for more careful research in organizations where delegate socialization is theoretically more likely. Such research should use scales more complex than those commonly used and should consider bodies “intermediate” between national governments and international organizations, such as permanent missions.
An institutional critique of intergovernmentalism: erratum
Authors: Garrett Geoffrey , Tsebelis George 
Published: May 2009

Please substitute the following for the definition on page 276 of our article in the Spring 1996 issue of International Organization (Volume 50, No. 2, pp.269–99):Definition. A coalition of m (out of n) members is nonconnected if there is a member i ε {N} – {M} that belongs in the Pareto set of {M}.
How Japan affects the international system
Authors: Schmiegelow Henrik , Schmiegelow Michèle 
Published: May 2009

To cope with more than incremental change in the international system, the neorealist concept of structure and the neoliberal concept of process must be complemented by a third analytically distinguished element: the concept of action. All three concepts can be used on the systemic level of analysis of international relations theory. Their obvious differentiation is the degree of systemic consolidation, with structure at the highest, action at the lowest, and process at unstable intermediate degrees. Without analyzing prevailing models of action of important units of the international system, it is impossible to predict the possible range of outcomes of processes and structural changes in the international system.This article offers Japan's “strategic pragmatism” as a model of action. The model, representing a functional cut across contending economic doctrines, combines relative fiscal conservatism with “progressive” provision of credit, dynamic capitalism with public policy activism, and critical rationalism with philosophical pragmatism. Japan's strategic pragmatism has not only enabled its government and enterprises to cope with uncertainty and change in their domestic and international environment but has also increased global welfare and changed the balance of strategic components of power in the international system. The spread of this model of action both within and beyond Japan's control points to a paradigm change in economic and international relations theory—that is, to the most pervasive form of systemic consolidation.
Middle power leadership and coalition building: Australia, the Cairns Group, and the Uruguay Round of trade negotiations
Authors: Higgott Richard A. , Cooper Andrew Fenton 
Published: May 2009

Perhaps the key question of debate among neorealist scholars of international political economy concerns the manner in which cooperation may or may not be secured in the global economic order "after hegemony," a question posed by Robert Keohane. A second broad question of interest to scholars of international politics concerns the manner in which weaker states attempt to influence stronger ones. A conflation of these two questions could cause scholars and practitioners alike to pay closer attention than they have in the past to coalitions of the weak as vehicles for cooperation and regime building in the global political economy.This article offers a case study of one recent exercise in coalition building as an attempt to foster cooperation in a "nonhegemonic" environment. Specifically, it examines the role of the Cairns Group of Fair Trading Nations in its attempts to foster reform in global agricultural trade within the current Uruguay Round of trade negotiations. The Cairns Group is shown to be an atypical, single-issue driven, transregional coalition. Led by Australia, the Group's actions represent an interesting exercise in "middle power" politics in a global economic order whose decisionmaking processes are increasingly more fragmented and complex and whose major actors need coaxing toward processes of cooperative economic management.
Efficacy of autologous fat injection laryngoplasty with an adenoviral vector expressing hepatocyte growth factor in a canine model
Authors: Umeno H , Chitose S , Murofushi Y , Kosai K , Sato K , Kawahara A , Nakashima T 
Published: May 2009

AbstractObjective:The effectiveness of autologous fat injection laryngoplasty may be reduced by resorption of injected fat tissue. The aim of the present study was to clarify the efficacy of fat injection laryngoplasty using autologous fat plus a replication-defective adenoviral vector expressing hepatocyte growth factor, regarding reduction of injected fat tissue resorption.Material and methods:Four female beagle dogs were used in this study. After sedation, a direct laryngoscope was introduced to enable visualisation of the larynx. In each dog, harvested autologous fat plus an adenoviral vector expressing hepatocyte growth factor was injected into the right true vocal fold, and harvested fat plus an adenoviral vector expressing no gene was injected into the left true vocal fold. A total laryngectomy was performed one year after the intracordal fat injection. Coronal sections of the resected whole larynges were made and the following parameters assessed using light and electron microscopy: size of fat area; number of vasculoendothelial cells surrounding adipocytes; and shape of injected adipocytes in the vocal fold.Results:The fat area was significantly larger and the number of vasculoendothelial cells surrounding adipocytes significantly greater in the intracordal fat injection containing adenoviral vector expressing hepatocyte growth factor, compared with the control intracordal fat injection containing adenoviral vector expressing no gene. When viewed under electron microscopy, the injected adipocytes were observed to have grafted better in the intracordal fat injection with hepatocyte growth factor adenoviral vector, compared with the control intracordal fat injection with adenoviral vector expressing no gene.Conclusions:Injection into the vocal fold of autologous fat containing an adenoviral vector expressing hepatocyte growth factor can reduce subsequent resorption of injected fat.
Comparative study of framework surgery and fat injection laryngoplasty
Authors: Umeno H , Chitose S , Sato K , Nakashima T 
Published: May 2009

AbstractObjective:To evaluate differences between the functional results of framework surgery and autologous fat injection laryngoplasty, for patients with unilateral vocal fold paralysis.Study design:Sixty-two patients underwent framework surgery, while 64 received autologous fat injection laryngoplasty. Voice function before and after both procedures was assessed using aerodynamic and acoustic analysis, with differences evaluated using pairedt-test in both groups.Results:In both groups, all parameters improved significantly after surgery, compared with before surgery. Post-operative improvement in all parameters was significantly greater after fat injection laryngoplasty, compared with framework surgery.Conclusion:Autologous fat injection laryngoplasty was thus found to be a more effective and reliable therapy for improving voice function in patients with vocal fold paralysis, compared with framework surgery.
Minor salivary gland carcinomas of oral cavity and oropharynx
Authors: Chijiwa H , Sakamoto K , Umeno H , Nakashima T , Suzuki G , Hayafuchi N 
Published: May 2009

AbstractThis paper reviews 22 cases of minor salivary gland carcinoma of the oral cavity or oropharynx which were treated at Kurume University Hospital between 1976 and 2005. Minor salivary gland carcinoma was observed in eight of 362 patients with cancer of the oral cavity (2 per cent), and in 14 of 275 patients with cancer of the oropharynx (5 per cent). The five-year and 10-year survival rates of patients with oropharyngeal minor salivary gland carcinoma were 90 per cent. No statistically significant difference was observed between survival rates for oropharyngeal minor salivary gland carcinoma and for oropharyngeal squamous cell carcinoma (p = 0.06). The five- and 10-year survival rates of patients with oral cavity minor salivary gland carcinoma were 75 and 37 per cent, respectively. No statistically significant difference was observed between survival rates for oral cavity minor salivary gland carcinoma and oral cavity squamous cell carcinoma.Patients' survival results correlated well with the clinical stage of their lesions. A significant difference in survival was observed, comparing stage IV with stages I, II and III (p = 0.04). In contrast, no significant relationship was found between either survival and tumour type or survival and treatment. Adjuvant therapy is recommended for patients with grade III adenoid cystic carcinoma with perineural infiltration or intravascular infiltration.
Epithelioid sarcoma of the neck: case report
Authors: Ueda Y , Chijiwa H , Nakashima T 
Published: May 2009

AbstractEpithelioid sarcoma is an aggressive, malignant tumour of the soft tissue which tends to arise in proximity to large tendons and aponeuroses. We report the case of a patient presenting with an epithelioid sarcoma arising in the neck. A 56-year-old man was referred with a three-year history of a sensory disorder as well as a slowly growing mass in his right neck. The patient underwent resection of the tumour by means of a conservative neck dissection. The final diagnosis, based on the histological and immunohistochemical findings, was epithelioid sarcoma. Radiotherapy was performed after the operation. The post-operative course was uneventful, and there was no local recurrence or distant metastasis.
Exploring the immunology of parasitism – from surface antigens to the hygiene hypothesis
Authors: MAIZELS R. M. 
Published: May 2009

SUMMARYHelminth immunology is a field which has changed beyond recognition in the past 30 years, transformed not only by new technologies from cDNA cloning to flow cytometry, but also conceptually as our definition of host immune pathways has matured. The molecular revolution defined key nematode surface and secreted antigens, and identified candidate immunomodulators that are likely to underpin parasites' success in eluding immune attack. The immunological advances in defining cytokine networks, lymphocyte subsets and innate cell recognition have also made a huge impact on our understanding of helminth infections. Most recently, the ideas of regulatory immune cells, in particular the regulatory T cell, have again overturned older thinking, but also may explain immune hyporesponsiveness observed in chronic helminth diseases, as well as the link to reduced allergic reactions observed in human and animal infections. The review concludes with a forward look to where we may make future advances towards the final eradication of helminth diseases.
The associations between socio-economic status and major depressive disorder among Blacks, Latinos, Asians and non-Hispanic Whites: findings from the Collaborative Psychiatric Epidemiology Studies
Authors: Gavin A. R. , Walton E. , Chae D. H. , Alegria M. , Jackson J. S. , Takeuchi D. 
Published: May 2009

BackgroundThis study examined whether there were associations between individual measures of socio-economic status (SES) and the 12-month prevalence of major depressive disorder (MDD) in representative samples of Blacks, Latinos, Asians and Whites in the USA.MethodThe data used were from the Collaborative Psychiatric Epidemiology Studies (CPES).ResultsThere was an association between household income and MDD among Whites. However, the association was not statistically significant. Statistically significant associations were present between educational attainment and MDD among Whites. Among both Whites and Latinos, being out of the labor force was significantly associated with MDD. In analyses by nativity, being out of the labor force was significantly associated with MDD among US-born and foreign-born Latinos.ConclusionsSignificant associations between various measures of SES and MDD were consistently observed among White and, in some cases, Latino populations. Future studies should continue to examine sociopsychological factors related to SES that increase the risk of MDD among people from racial-ethnic communities.
Experimental identification of the dynamics model for 6-DOF parallel manipulators
Authors: Abdellatif Houssem , Heimann Bodo 
Published: May 2009

SUMMARYThe paper presents a self-contained approach for the dynamics identification of six degrees of freedom (DOF) parallel robots. Major feature is the consequent consideration of structural properties of such machines to provide an experimentally adequate identification method. The known periodic excitation is modified and enhanced to take the actuator coupling as well as the numerical solution of the direct kinematics into account. The benefits of explicit frequency-domain data filtering are demonstrated. Additionally, a new implementation of the maximum-likelihood estimator allows for automatic tuning of the data filter. The issue of optimal input experiment design is also discussed and substantiated with extensive experiments.
A saturated PD controller for robots equipped with brushless DC-motors
Authors: Hernández-Guzmán V. M. , Santibáñez V. , Zavala-Río A. 
Published: May 2009

SUMMARYIn this paper we are concerned with control of rigid robots equipped with brushless DC-motors (BLDC) when the electric dynamics of these actuators is taken into account. We show for the first time that a saturated PD controller suffices to achieve global asymptotic stability. Our controller is the simplest controller proposed until now to solve this problem: it only requires position measurements and linear feedback of electric current.
Histone deacetylase inhibition improves meiotic competence but not developmental competence in growing pig oocytes
Authors: Petr J. , Chmelíková E. , Kheilová K. , Jílek F. 
Published: May 2009

SummaryIn fully grown pig oocytes, meiotic maturation in vitro is retarded by inhibition of histone deacetylases by trichostatin A (TSA). In growing oocytes with partial meiotic competence, culture with TSA has no significant effect on the meiotic maturation. Growing oocytes treated with TSA mature mainly to metaphase I. The ratio of oocytes that mature to metaphase II is very limited. After transient exposure to TSA, the maturation of growing oocytes with partial meiotic competence takes a different course. When these oocytes are first cultured in a TSA-free medium, then cultured for another 24 h with 100 nM TSA and finally again in a TSA-free medium for 24 h, the ratio of oocytes that mature to metaphase II significantly increases reaching 59%. When oocytes were cultured for the same length of time without transient exposure to TSA, only 19% matured to metaphase II. Those oocytes that matured to metaphase II after transient exposure to TSA were successfully activated using calcium ionophore. However, the subsequent cleavage was very limited. We can conclude that transient exposure of growing pig oocytes with partial meiotic competence to TSA increases oocyte meiotic competence, but it does not enhance developmental competence after parthenogenetic activation.