bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermodynamic Pathways of Vertical Wind Shear Impacting Tropical Cyclone Intensity Change: Energetics and Lagrangian Analysis
Authors: Liu Zi-Qi , Tan Zhe-Min 
Published: May 2024

Abstract
This study analyzes the variations in the thermodynamic cycle and energy of a tropical cyclone (TC) under the influence of vertical wind shear (VWS), exploring the possible thermodynamic pathways through which VWS affects TC intensity. The maximum energy harnessed by the TC diminishes alongside a decrease in storm intensity in the presence of VWS. In the sheared TC, the ascending branch of the thermodynamic cycles of TC shifts toward lower entropy, which is related to the reduction in entropy in the eyewall and/or the increase in entropy and enhanced upward motion outside the eyewall. Moreover, the descending leg shifts toward higher entropy due to the increase in entropy and weakening of downward motion in both the ambient environment and the upper troposphere. These changes in the ascending and descending branches could reduce the work done by the heat engine cycle, with the former playing a primary role in the presence of VWS. Given that the ascending branch is influenced by the eyewall and the rainbands outside the eyewall under VWS, the thermodynamic pathways could be categorized into inner ventilation and outer ventilation based on the location of their roles. The pathways associated with inner ventilation primarily reduce the entropy in the eyewall. In addition to the conventional low- and midlevel ventilation, the inner ventilation also encompasses new pathways entering the midlevel eyewall after descending from the upper level and ascending from the boundary layer. Conversely, the pathways of outer ventilation are related to the increase in the entropy outside the eyewall. These include the ascent of high-entropy air to the middle and upper troposphere related to the inner and outer rainbands, the outward advection of high-entropy air from the eyewall in the midlevel and upper level, and air warming by the descending draft from the upper- to midlevel troposphere. These insights contribute to a nuanced understanding of the sophisticated interactions within TCs and their response to VWS.

Significance Statement
Vertical wind shear (VWS) is known to modify the thermodynamic structure of tropical cyclones (TCs), thereby affecting their development. The incorporation of multiple thermodynamic mechanisms amplifies the complexity of related studies and predictions. Within the context of a unified heat engine framework, this study aims to paint a relatively comprehensive picture of the key thermodynamic pathways through which VWS impacts the intensity of TCs. Contrary to previous studies, we emphasize the increase in entropy and the intensified upward motion outside the eyewall, which play pivotal roles in diminishing the intensity of TCs in the presence of VWS. Gaining an understanding of these critical mechanisms and structural changes offers insights and guidance that can enhance the prediction of sheared TCs.
Thermodynamical Effects of Ocean Current Feedback in a Quasigeostrophic Coupled Model
Authors: Jamet Quentin , Berger Alexandre , Deremble Bruno , Penduff Thierry 
Published: May 2024

Abstract
Air–sea fluxes are the main drivers of ocean circulation, yet their representation in ocean-only models remains challenging. While a zeroth-order formulation accounting only for the state of the atmosphere is well adopted by the community, surface ocean feedback has gained attention over the last decades. In this paper, we focus on thermodynamical indirect feedback of surface ocean currents, which completes the “eddy killing” effect induced by the mechanical feedback. In this study, we quantify both the mechanical and thermodynamical contributions in the context of idealized, coupled quasigeostrophic simulations through sensitivity experiments on wind stress formulation. As compared to eddy killing which impacts kinetic energy levels, the indirect thermodynamical feedback induces significant changes in potential energy levels. The thermodynamical feedback also enhances by +27% the potential-to-kinetic turbulent energy conversion induced by relative wind stress formulation, as well as significant changes in both forward and inverse cascades of potential energy (PE). That is, accounting for ocean surface currents in the computation of wind stress significantly changes transfers of PE from the mean to the turbulent flow. These changes are mostly controlled by a reduced upscale energy flux rather than a more vigorous downscale flux, a process in line with results obtained for kinetic energy fluxes associated with the eddy killing effect.
The FAITHS2 Model Predicts Functional Disability in Patients With Acute Ischemic Stroke
Authors: Wang Meng , Han Ying , Zhou Qi , Wang Chun-Juan , Meng Xia , Jiang Yong , Yang Xin , Zhang Jing , Xiong Yun-Yun , Zhao Xing-Quan , Liu Li-Ping , Wang Yi-Long , Wang Yong-Jun , Gu Hong-Qiu , Li Zi-Xiao 
Published: May 2024

The present study aimed to develop a model to predict functional disability at 3 months in patients with acute ischemic stroke (AIS) ( n = 5,406). The primary outcome was functional disability (modified Rankin Scale [mRS] >2) at 3 months. A prediction model including blood biomarkers was developed based on a multivariable logistic regression model, which was internally validated by the 100-time bootstrap method. A nomogram and a web-based calculator were developed for usage in clinical practice. At 3 months, 11% (638/5,406) of the patients had functional disability. Seven independent predictors of functional disability at 3 months were incorporated into the FAITHS2 model (fasting plasma glucose, age, interleukin-6, stroke history, National Institute of Health Stroke Scale [NIHSS] at admission, sex, and systolic blood pressure). The Area Under Curves (AUCs) were 0.814 (95% confidence interval [CI] 0.796–0.832) and 0.808 (95% CI 0.806–0.810), and the Brier scores were 0.088 ± 0.214 and 0.089 ± 0.003 for the derivation cohort and internal validation, respectively, showing optimal performance of the model. The FAITHS2 model has excellent potential to be a dependable application for individualized clinical decision making.
‘Your heart is resting and pumping at the same time’: Mental health impact of seeking asylum among sexual minority men
Authors: Gottvall Maria , Isaac Rummage , Ainembabazi Ronah , Yasin Sumera , Eldebo Anna , Carlsson Tommy 
Published: May 2024

Aims: To explore the experiences of seeking asylum and its impact on mental health among sexual minority forced migrant cisgender men living in Sweden. Methods: Exploratory qualitative study based on individual semi-structured interviews with 15 adult gay and bisexual cisgender men recruited via a combination of purposeful, convenience and snowball sampling. Data were analysed with systematic text condensation through a collaborative approach with three migrants with lived experience. Results: Seeking asylum had been an emotionally challenging journey for the participants in this study, involving several procedures that negatively impacted mental health. Being expected to disclose intimate information during asylum interviews had been a significant challenge, alongside needing to wait through long periods in uncertainty with little information about the progress of their asylum case. The behaviours and attitudes of professionals involved in the legal procedures had been a central aspect, as participants encountered interpreters and caseworkers who acted disrespectful and homophobic during asylum interviews. Participants mentioned that the behaviours of interpreters and the accuracy of the interpretation could influence the outcome of asylum claims and how comfortable they felt in sharing information. Thus, participants emphasized the importance of adequate and accurate interpreter services. Conclusions: Sexual minority men are faced with an unfamiliar and emotionally challenging position when seeking asylum and undergoing asylum interviews. The findings highlight the importance of adequate competence among professionals involved in asylum interviews, including interpreter utilization. Research is needed to determine effective methods to support these men throughout their asylum process.
Contested places: A typology for responding to place-based harms
Authors: Thurber Amie , Krings Amy , Sawyer Jason , Hamilton Greer A , Gutiérrez Mónica 
Published: May 2024

Summary: In response to historic and ongoing devaluation of certain people, and concurrently, the places they live, many communities are grappling with how to respond to place-based harms. This has produced a wide range of responses, such as calls for “Land Back,” reparations programs, arts-based neighborhood regeneration, and local history initiatives. This paper explores the potential roles community practitioners can play in these contested places. Drawing on a review of the literature, this paper offers an emerging typology for responding to place-based harms. Findings: The proposed typology includes six place-based approaches: Reparation, Remembrance, Regeneration, Resistance, Harm-Reduction, and Repatriation/Rematriation. The authors distinguish each approach by its target and temporal focus, common strategies, primary change agents, and vulnerabilities. While drawing on transdisciplinary scholarship, authors also describe social work's engagement with each approach. Applications: This emerging typology may assist social work practitioners, scholars, and students as they study and employ strategies for intervening in contested spaces. It also suggests areas for future research in conjunction with responses to place-based harms.
Premenstrual dysphoric disorder and associated factors among university graduating class female students in Ethiopia: A cross-sectional study
Authors: Abdeta Tilahun , Firdisa Dawit , Mulugeta Abiy , Dereje Jerman 
Published: May 2024

Objectives: Premenstrual dysphoric disorder is a somatopsychic condition that develops about a week before the start of menstruation and is brought on by fluctuating sex steroid levels that follow an ovulatory menstrual cycle. Therefore, this study aimed to assess the magnitude of premenstrual dysphoric disorder and associated factors among Haramaya University graduating class female students, in eastern Ethiopia. Methods: An institutional-based cross-sectional study was conducted from 1 to 30 November 2022 among Haramaya University graduating class female students using a simple random sampling technique. The data were cleaned, coded, and entered into the Epi-data 3.01 before being exported and analyzed with Statistical Package of Social Science 20 versions. The premenstrual dysphoric disorder was assessed by the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision. To identify associated factors a bivariable logistic regression analysis was conducted to determine the association between each independent variable and the outcome variable. The multivariable logistic regression model includes all variables with a p-value of less than 0.25 in the bivariate logistic regression analysis. The adjusted odds ratio with a 95% confidence interval was computed when the p-value was less than 0.05, which was considered statistically significant. Results: Out of 282 samples, 274 study participants were involved providing a response rate of 97.2%. The prevalence of premenstrual dysphoric disorders was 64.6% (95% CI: 59.5–70.4). Participants with the irregular menstrual cycle (AOR = 2.24; 95% CI: 1.26–4.34), heavy menstrual flow (AOR = 2.53; 95% CI: 1.84–7.59), moderate menstrual flow (AOR = 2.29; 95% CI: 1.02–5.26), severe menstrual pain (AOR = 5.69; 95% CI: 1.86–7.42) and those who have depressive symptoms (AOR = 2.46, 95% CI: 1.08–5.68) were variables associated with premenstrual dysphoric disorders. Conclusion: The prevalence of premenstrual dysphoric disorder was relatively high. Severe menstrual pain, menstrual irregularity, heavy menstrual flow, and a history of depression had significant associations with premenstrual dysphoric disorder. It will be better if higher institution administrators design and implement methods to screen and intervene premenstrual dysphoric disorder among female students.
Expert review of child and caregiver critiques of a therapeutic guided imagery therapy mobile application targeting disorders of gut–brain interaction in children
Authors: Hollier John M , Strickland Tiantá A , Fordis C Michael , Shulman Robert J , Thompson Debbe 
Published: May 2024

Background A guided imagery therapy mobile application (GIT App) is a novel platform for treating children with disorders of gut–brain interaction (DGBI). Previous feedback from child/caregiver dyads suggested modifications for our App prototype. However, their feedback had the potential to affect the intervention's efficacy. Thus, we aimed to have their critiques vetted by relevant experts prior to further App refinement. Objective Compare expert reviews of the GIT App with end-users’ (i.e., child/caregiver dyads’) feedback. Methods This mixed-methods study with experts included a hands-on App evaluation, a survey assessing usability, and focus groups comparing their perspectives with those previously provided by end-users. Results Eight medical and technology experts were enrolled. Their average usability survey score of the GIT App was 69.0 ± 27.7, which was marginally above the 50th percentile. While the expert and end-user usability assessments were generally favorable, both groups agreed that the App's reminder notification feature location was not intuitive, detracting from its usability. Experts agreed with end-users that the App's aesthetics were acceptable and suggested increasing icon and font sizes. Like the end-users, the experts did not achieve consensus regarding the ideal session length or inclusion of background sounds and screen animations. Lastly, the experts agreed with end-users that gamification techniques (e.g., gift cards and virtual badges) would promote user engagement. Conclusion An expert review of our therapeutic App revealed findings consistent with end-users and provided insight for modifying the interface and GIT sessions. Based on this experience, we recommend expert vetting of end-user suggestions as a routine checkpoint when developing therapeutic Apps.
Comparison of Contralateral ACL Rupture Versus ACL Graft Rupture in Australian Netballers After ACL Reconstruction
Authors: Honeywill Conor , Salmon Lucy , Pinczewski Leo , Sundaraj Keran , Roe Justin 
Published: May 2024

Background: Netball is a popular sport worldwide, particularly for women. However, its nature puts players at high risk for anterior cruciate ligament (ACL) injury. Purpose: To determine (1) the prevalence of ACL graft rupture and contralateral ACL (CACL) rupture in Australian female netballers after ACL reconstruction (ACLR) and (2) the rate of return to sports (RTS) and psychological readiness. Study Design: Cohort study; Level of evidence, 3. Methods: A patient database identified 332 consecutive female netball players who underwent ACLR with hamstring tendon autografts performed by 2 surgeons between 2007 and 2015. Patients were retrospectively surveyed at a minimum of 7 years postoperatively—including details of a second ACL injury to either knee, RTS, and psychological readiness per the ACL–Return to Sport After Injury (ACL-RSI) score. Multivariate regression assessed the association between selected variables and repeat ACL injury. Results: A total of 267 patients (80%) were included with a mean follow-up of 8.4 years (range, 7-15 years). ACL graft rupture and CACL rupture occurred in 11 (4%) and 27 (10%) patients, respectively, at 7 years postoperatively. The ACL graft had a survival rate of 99%, 97%, 97%, and 96% at 1, 2, 5, and 7 years after surgery, respectively. The native CACL had a survival rate of 100%, 99%, 94%, and 90% at 1, 2, 5, and 7 years, respectively. Adolescents had a 4.5 times greater hazard for ACL graft rupture (95% CI, 1.4-14.6; P = .014) and a 2.5 times greater hazard for CACL rupture (95% CI, 1.2-5.5; P = .021) compared with adults. CACL injury was also associated with a return to level 1—including jumping, hard pivoting, and cutting—sports (hazard ratio, 10.3 [95% CI, 1.4-77.1]; P = .023). Most (62%) participants returned to netball, with those with higher ACL-RSI scores more likely to RTS. Conclusion: The prevalence of repeat ACL injury was higher in the contralateral knee (10%) than the ACL-reconstructed knee (4%) at 7 years postoperatively. ACLR was a suitable option for female netballers who sustained an ACL rupture with low long-term rates of graft rupture. Repeat ACL injuries to either knee were more common in adolescents and those who returned to cutting and pivoting sports.
Prevalence of Cyberbullying Perpetration and Cyberbullying Victimization among Nursing Students in Jordan
Authors: Al-shatnawi Fida’a Eid , Ababneh Amal Mohammad Taisir , Elemary Fatma Mahmoud , Rayan Ahmad , Baqeas Manal Hassan 
Published: May 2024

Introduction Cyberbullying is a form of bullying or harassment carried out online with the intent to harm others mainly using social media sites. Objective To investigate cyberbullying prevalence and associated factors among nursing students in Jordan. Methods A descriptive, cross-sectional study was conducted. A convenience sample of 428 Jordanian nursing students from three private Jordanian universities was involved in the study. Data were collected in 2022 using the sociodemographic characteristics sheet, cyberbullying perpetration (CBP) scale; and cyberbullying victimization (CBV) scale. Multiple linear regression analysis was performed to identify variables associated with the CBP and CBV scores. Results About 30.1% of the students were not involved in any cyberbullying, while 8.6% were categorized as cyberbullying perpetrators only, 20.4% as victims only, and 40.9% were categorized as cyberbullying perpetrators and victims at the same time. Visual /sexual perpetration and verbal/written victimization were the most prevalent forms of cyberbullying among the studied nursing students. Increasing age was associated with a decreased CBP ( P < 0.05) and CBV ( P < 0.01), while male gender was associated with increased cyberbullying perpetration ( P < 0.01). Conclusions The prevalence of cyberbullying among nursing students in the current study was alarming. The study showed that age was negatively associated with CBP and CBV while being male was associated with increased CBP. Future research may want to consider using a longitudinal research design with more testing variables and a more comprehensive examination of potential causes and impacts of cyberbullying in nursing students. The development of specific policies to combat cyberbullying among Jordanian nursing students is also recommended.
Early adversity and family resilience factors in children with autism spectrum disorder: A narrative review
Authors: Kuenzel Elizabeth , Duerden Emma G. 
Published: May 2024

Global estimates indicate that autism is a neurodevelopmental condition that is currently diagnosed in 1 in 100 people across the world. Autistic children can experience deficits in social communication, often linked to difficulties with joint attention and facial emotion recognition. Restrictive repetitive behaviors and interests (RRBIs) are also part of the diagnostic criteria of autism and are associated with lower adaptive skills. Due to social challenges and RRBIs exhibited by autistic children, they may be at higher risk for experiencing social and familial stressors. In non-autistic children, early adversity is predictive of deficits in executive functioning, neurological changes, and poor adult health. However, resilience factors have been identified, which can offset the negative impacts of adversity. In autistic children, these protective factors may have differential downstream influences on children's outcomes due to cognitive and social difficulties. In this narrative review, we report that autistic children are more likely to experience familial and environmental stressors compared to non-autistic children. Resilience factors such as positive parenting, sleep, social relationships, and executive functioning skills were identified as key areas for future research. Lay summary Children with autism are statistically more likely than their peers to be exposed to adverse childhood events including bullying, parental divorce, and poverty. The more severely affected a child is by autism the greater the likelihood they will be exposed to early life stress. This indicates that the most vulnerable children with autism who have limited adaptive skills to promote resilience to stress may have the highest exposure to stressful events during their childhood. In turn, a better understanding of how early adversity impacts children with autism is needed as well to characterize resilience factors that promote optimal outcomes. In this review of the literature, it was found that children with autism may experience more stress from their family and surroundings compared to children without autism. Factors that can help these children cope better were identified, including supportive parenting, getting enough sleep, having friends, and having good problem-solving skills. This research could help parents and teachers better understand how to support children with autism who are experiencing early adversity.
CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia
Authors: Mazziotta Francesco , Biavati Luca , Rimando Joseph , Rutella Sergio , Borcherding Nicholas , Parbhoo Sonali , Mukhopadhyay Rupkatha , Chowdhury Sayan , Knaus Hanna A. , Valent Peter , Hackl Hubert , Borrello Ivan M. , Blazar Bruce R. , Hatzi Katerina , Gojo Ivana , Luznik Leo 
Published: May 2024

Abstract
The interplay between T-cell states of differentiation, dysfunction, and treatment response in acute myeloid leukemia (AML) remains unclear. Here, we leveraged a multimodal approach encompassing high-dimensional flow cytometry and single-cell transcriptomics and found that early memory CD8+ T cells are associated with therapy response and exhibit a bifurcation into 2 distinct terminal end states. One state is enriched for markers of activation, whereas the other expresses natural killer (NK)-like and senescence markers. The skewed clonal differentiation trajectory toward CD8+ senescence was also a hallmark indicative of therapy resistance. We validated these findings by generating an AML CD8+ single-cell atlas integrating our data and other independent data sets. Finally, our analysis revealed that an imbalance between CD8+ early memory and senescent-like cells is linked to AML treatment refractoriness and poor survival. Our study provides crucial insights into the dynamics of CD8+ T-cell differentiation and advances our understanding of CD8+ T-cell dysfunction in AML.
Targeting the tumor microenvironment for treating double-refractory chronic lymphocytic leukemia
Authors: Lewis Richard I. , vom Stein Alexander F. , Hallek Michael 
Published: May 2024

Abstract
The introduction of BTK inhibitors and BCL2 antagonists to the treatment of chronic lymphocytic leukemia (CLL) has revolutionized therapy and improved patient outcomes. These agents have replaced chemoimmunotherapy as standard of care. Despite this progress, a new group of patients is currently emerging, which has become refractory or intolerant to both classes of agents, creating an unmet medical need. Here, we propose that the targeted modulation of the tumor microenvironment provides new therapeutic options for this group of double-refractory patients. Furthermore, we outline a sequential strategy for tumor microenvironment-directed combination therapies in CLL that can be tested in clinical protocols.