bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparisons of Differential Analysis Methods between mRNAs and Parkinson’s Disease
Authors: Aung Tun Lin , Aung Ye Win , Myint Khin Sandi , Shi Xiaoran 
Published: May 2024

Abstract

Background
Parkinson's disease (PD) is a chronic, progressive neurodegenerative illness presenting motor and nonmotor symptoms. The primary pathology involves the gradual degeneration of dopaminergic neurons substantia nigra in the midbrain, causing motor dysfunction. PD is linked with changing gene expression, especially in the dopamine-dependent oxidative stress passages. Messenger RNA is a vital intermediary in gene expression, and dysregulation may exacerbate neuroinflammation and neuronal damage.
Objectives
Our objective was to identify differentially expressed mRNAs in PD through diverse analysis methods, comparing commonly utilized differential analysis techniques. This aims to enhance the understanding of underlying molecular mechanisms, elucidating affected biological significance, pathways, and processes in PD.
Methods
We employed the GEO database to investigate mRNA expressions in PD using the GSE168496 dataset. Utilizing the R-programming packages edgeR and DESeq2, we performed differential expression analysis. A Venn Diagram compares the differential expression genes (DEGs) identified by edgeR and DESeq2. Subsequently, a functional enrichment and regulatory network analysis was conducted on the significantly differing DEGs between PD and healthy controls (HC).
Results
The study used edgeR and DESeq2 to find PD with an adjusted p-value of less than 0.05 as the significance criterion. There was evidence of the downregulation of 17 genes (ALDH1A1, AGTR1, PITX3, RSPO2, and others) and the upregulation of five genes (LAMB1, MCOLN3, CYP2W1, MLPH, COL5A1). Utilizing Reactome Gene Sets, WikiPathways, and KEGG Pathway analyses unveiled biological processes associated with PD, including dopaminergic neurogenesis and synapse. Protein-protein interaction analysis highlighted 16 crucial proteins with 20 interactions, providing insights for therapeutic interventions and further research.
Conclusion
In conclusion, we identified distinct gene expression patterns, revealing five upregulated biomarkers and 17 downregulated markers in PD compared to HC. Combining differential expression analysis, pathway enrichment, network visualization, and Protein-Protein Interaction exploration provided a robust foundation for understanding the molecular intricacies of PD, offering valuable insights for future research and therapeutic development.
Optimum Condition for the Formation of β-ionone by Thermal Decomposition of Carotenoids Extract from Orange Sweet Potato (Ipomoea Batatas L.)
Authors: &#160 Aisman , Syukri Daimon , &#160 Rini , &#160 Jaswandi , Haiyee Zaibunnisa Abdul 
Published: May 2024

Introduction
The need for rose aromatic compounds is very high globally, where the beta-ionone compound as a precursor for rose aroma can be produced through the oxidation process of carotenoids, especially beta carotene. Therefore, Beta-ionone is the compound responsible for the rose fragrance, which is needed industrially. Carotenoids are easily degraded by various factors, namely heat, oxygen, light and enzymatic. This research has carried out heat degradation of carotene compounds extracted from orange sweet potato to determine the effect of heating time on forming aromatic compounds such as Beta-ionone and dihydroactinidiolide (dhA).

Methodology
Thermal degradation of carotene was carried out at 140°C for 1, 2, 3, and 4 h. The constant oxygen concentration of 7 l.h-1 was used to induce the oxidation. The spectrophotometric analysis of total carotene and the gas chromatographic-mass spectrometry analysis of volatile compounds were conducted to clarify the efficiency of the carotene degradation process and aromatic compounds' formation, respectively.

Results
Orange sweet potatoes contain 1.2% of carotenoids on a dry weight basis. Beta-ionone and dihydroactinidiolide compounds increased along with decreased total carotene value during heating. The results showed that heating sweet potato carotene at 140°C for 4 h caused carotene degradation of up to 93%. Therefore, the optimum thermal degradation treatment for the formation of β-ionone and dhA compounds was the heating condition at a temperature of 140°C for 4 h.

Conclusion
This research has shown the potential of sweet potatoes as a non-aromatic raw material that can be used to produce aromatic compounds. The use of the crude extract in this research means that the beta-ionone content in the product after oxidation is still low due to the presence of other components; this needs to be a concern for further research.
Ralstonia mannitolilytica Infections: A Systematic Review of Case Reports
Unveiling Clinical Patterns and Therapeutic Insights
Authors: Neelambaran Krishnapriya , Velmurugan Hemasri , Venkatesan Sajitha , Thangaraju Pugazhenthan 
Published: May 2024

Background:
Ralstonia mannitolilytica is an emerging opportunistic pathogen that has
been increasingly reported in clinical settings. Despite its low pathogenicity in immunocompetent
individuals, it poses a significant threat to immunocompromised patients, particularly those with
underlying medical conditions or invasive medical interventions.

Objectives:
This study aimed to evaluate the clinical impact and management strategies based on
the analysis of individual case reports on Ralstonia mannitolilytica .

Methods:
A comprehensive search of PubMed was conducted from inception until July 31, 2023,
using the terms “Ralstonia mannitolilytica” and/or “Pseudomonas thomasii”. Inclusion criteria for
our systematic review included human-centered case reports of Ralstonia mannitolilytica infections, excluding case series and review articles. Data extraction followed PRISMA guidelines, including study details and patient characteristics. Case reports were systematically assessed using
the JBI critical appraisal checklist, evaluating patient demographics, clinical history, diagnostic
methods, interventions, post-intervention outcomes, adverse events, and lessons learned to minimize bias risk.

Results:
A total of 17 case reports of Ralstonia mannitolilytica infections were included in our systematic review. Studies published from 2001 to 2023 revealed diverse global contributions, with
29.41% from China. Infection origins varied, with catheter-related cases being predominant. Mortality was reported in two studies. Antibiotic sensitivity analysis showed sensitivity to third-generation cephalosporins, notably Ceftazidime. Quality appraisal revealed that all studies had a low risk
of bias, ensuring the overall robustness of the case reports.

Conclusion:
This study emphasizes the importance of understanding Ralstonia mannitolilytica infections, given their varied clinical presentations and antibiotic responses. The study also underscores the necessity for precise identification, customized treatments, and ongoing research to manage these infections effectively.
Characteristic Changes of the Stance-Phase Plantar Pressure Curve When Walking Uphill and Downhill: Cross-Sectional Study
Authors: Wolff Christian , Steinheimer Patrick , Warmerdam Elke , Dahmen Tim , Slusallek Philipp , Schlinkmann Christian , Chen Fei , Orth Marcel , Pohlemann Tim , Ganse Bergita 
Published: May 2024

Background
Monitoring of gait patterns by insoles is popular to study behavior and activity in the daily life of people and throughout the rehabilitation process of patients. Live data analyses may improve personalized prevention and treatment regimens, as well as rehabilitation. The M-shaped plantar pressure curve during the stance phase is mainly defined by the loading and unloading slope, 2 maxima, 1 minimum, as well as the force during defined periods. When monitoring gait continuously, walking uphill or downhill could affect this curve in characteristic ways.

Objective
For walking on a slope, typical changes in the stance phase curve measured by insoles were hypothesized.

Methods
In total, 40 healthy participants of both sexes were fitted with individually calibrated insoles with 16 pressure sensors each and a recording frequency of 100 Hz. Participants walked on a treadmill at 4 km/h for 1 minute in each of the following slopes: −20%, −15%, −10%, −5%, 0%, 5%, 10%, 15%, and 20%. Raw data were exported for analyses. A custom-developed data platform was used for data processing and parameter calculation, including step detection, data transformation, and normalization for time by natural cubic spline interpolation and force (proportion of body weight). To identify the time-axis positions of the desired maxima and minimum among the available extremum candidates in each step, a Gaussian filter was applied (σ=3, kernel size 7). Inconclusive extremum candidates were further processed by screening for time plausibility, maximum or minimum pool filtering, and monotony. Several parameters that describe the curve trajectory were computed for each step. The normal distribution of data was tested by the Kolmogorov-Smirnov and Shapiro-Wilk tests.

Results
Data were normally distributed. An analysis of variance with the gait parameters as dependent and slope as independent variables revealed significant changes related to the slope for the following parameters of the stance phase curve: the mean force during loading and unloading, the 2 maxima and the minimum, as well as the loading and unloading slope (all P<.001). A simultaneous increase in the loading slope, the first maximum and the mean loading force combined with a decrease in the mean unloading force, the second maximum, and the unloading slope is characteristic for downhill walking. The opposite represents uphill walking. The minimum had its peak at horizontal walking and values dropped when walking uphill and downhill alike. It is therefore not a suitable parameter to distinguish between uphill and downhill walking.

Conclusions
While patient-related factors, such as anthropometrics, injury, or disease shape the stance phase curve on a longer-term scale, walking on slopes leads to temporary and characteristic short-term changes in the curve trajectory.
Patient and Provider Perspectives About the Use of Patient-Generated Health Data During Pregnancy: Qualitative Exploratory Study
Authors: MacEwan Sarah R , Olvera Ramona G , Jonnalagadda Pallavi , Fareed Naleef , McAlearney Ann Scheck 
Published: May 2024

Background
There is increasing interest in using patient-generated health data (PGHD) to improve patient-centered care during pregnancy. However, little research has examined the perspectives of patients and providers as they report, collect, and use PGHD to inform obstetric care.

Objective
This study aims to explore the perspectives of patients and providers about the use of PGHD during pregnancy, including the benefits and challenges of reporting, collecting, and using these data, as well as considerations for expanding the use of PGHD to improve obstetric care.

Methods
We conducted one-on-one interviews with 30 pregnant or postpartum patients and 14 health care providers from 2 obstetrics clinics associated with an academic medical center. Semistructured interview guides included questions for patients about their experience and preferences for sharing PGHD and questions for providers about current processes for collecting PGHD, opportunities to improve or expand the collection of PGHD, and challenges faced when collecting and using this information. Interviews were conducted by phone or videoconference and were audio recorded, transcribed verbatim, and deidentified. Interview transcripts were analyzed deductively and inductively to characterize and explore themes in the data.

Results
Patients and providers described how PGHD, including physiologic measurements and experience of symptoms, were currently collected during and between in-person clinic visits for obstetric care. Both patients and providers reported positive perceptions about the collection and use of PGHD during pregnancy. Reported benefits of collecting PGHD included the potential to use data to directly inform patient care (eg, identify issues and adjust medication) and to encourage ongoing patient involvement in their care (eg, increase patient attention to their health). Patients and providers had suggestions for expanding the collection and use of PGHD during pregnancy, and providers also shared considerations about strategies that could be used to expand PGHD collection and use. These strategies included considering the roles of both patients and providers in reporting and interpreting PGHD. Providers also noted the need to consider the unintended consequences of using PGHD that should be anticipated and addressed.

Conclusions
Acknowledging the challenges, suggestions, and considerations voiced by patients and providers can inform the development and implementation of strategies to effectively collect and use PGHD to support patient-centered care during pregnancy.
PERAN NILAI-NILAI GAMIFIKASI DAN SOSIAL TERHADAP ADOPSI E-COMMERCE
Authors: Ammalia Adinda Risky , Sumar Sumar 
Published: May 2024

This study aims to identify the factors that generate social and shopping motivations that lead to favorable attitudes toward e-commerce applications in gamification. The research methodology used primary data from an online questionnaire. A sample of 151 e-commerce application users who play games on e-commerce platforms was collected and analyzed using structural equation modeling. The results showed that exposure to the network through gamification significantly impacts social influence, perception, and mutual benefit. The more a user interacts with other users in the network, the greater his or her participation in the gamification system. Thus, the more extensive the network, the greater the potential for recognition and exposure to more social environments. Recognition and reciprocal benefits were found to have no significant effect on attitudes. This study provides practical recommendations for implementing gamification in e-commerce application platforms. This study provides a better understanding of the application of gamification in e-commerce by examining social interactions within the game and shopping behavior in e-commerce that continuously use the platform.
Keywords: Gamification; Network Exposure; Social Influence; Reciprocal Benefit; Recognition
Abstrak
Tujuan dari penelitian ini adalah untuk mengidentifikasi faktor-faktor yang menciptakan motivasi sosial dan belanja yang mengarah pada sikap positif untuk aplikasi e-commerce dalam konteks gamifikasi. Metodologi penelitian menggunakan data primer dari kuesioner online, 151 pengguna aplikasi e-commerce yang memainkan game di platform e-commerce dikumpulkan sebagai sampel penelitian dan dianalisis menggunakan model persamaan struktural. Hasil penelitian menunjukkan bahwa paparan jaringan melalui gamifikasi berpengaruh secara signifikan terhadap pengaruh sosial, pengakuan dan manfaat timbal balik. Semakin banyak pengguna yang terpapar ke pengguna lain dalam jaringan, mereka akan lebih terlibat dalam sistem gamifikasi. Dengan demikian, ketika jaringan semakin besar, kemungkinan mendapatkan pengakuan dan terpapar lebih sosial di lingkungan juga akan lebih besar. Pengakuan dan manfaat timbal balik tidak ditemukan signifikan mempengaruhi sikap. Penelitian ini memberikan rekomendasi praktis untuk aplikasi e-commerce dalam menerapkan gamifikasi ke dalam platform mereka. Penelitian ini memberikan pemahaman yang lebih baik tentang penerapan gamifikasi di e-commerce dengan mengkaji interaksi sosial dalam game dan perilaku belanja di e-commerce yang terus menggunakan platform tersebut.
Kata Kunci: Gamifikasi; Paparan Jaringan; Pengaruh Sosial; Manfaat Timbal Balik; Pengakuan
ANATOMICAL MODELING OF THE SUPERFICIAL MUSCLES OF NECK IN PERINATAL PERIOD OF ONTOGENESIS
Authors: Tsumanets Iryna 
Published: May 2024

The analysis of the literature indicates the high interest of not only domestic, but also foreign scientists in the anatomy and topography of the neck muscles at various stages of ontogenesis for adequate surgical correction of abnormalities in newborns and young children. The study was performed on 63 objects of human fetuses aged from 4 to 10 months and 7 newborns (in particular, 5 isolated organ complexes). For create anatomical models of the surface muscles of the neck, muscle parameters and commonly known neck sizes were determined in all age groups. The length of the muscles was determined from the place of its beginning to the place of attachment, the width – at the level of its widest part, that is, at the level of the anatomical diameter. Statistical analysis of the obtained data was performed using the licensed program RStudio. For the morphometric parameters of the sternocleidomastoid and scapulohyoid muscles during the perinatal period of development, periods of accelerated development are characteristic, for the length of the sternocleidomastoid muscle – from the 5th to the 9th month, for the length scapular- hyoid muscle – from the 4th to the 6th month of intrauterine development. For width of the right and left sternocleidomastoid muscle has two periods of the most intense increase: during 5-6 and 8-10 months of development, while the width of the right and left scapulohyoid muscle increases gradually during this period of development. The created anatomical model based on the morphometric parameters of the surface muscles of the neck is a template for all age groups during the perinatal period of ontogenesis with the aim of establishing typical and variant anatomy with the subsequent prediction of developmental abnormalities or congenital pathology. The established correlation relationships between the morphometric parameters of the sternoclavicular mastoid and scapular- hyoid muscles during the perinatal period of development testify to their synchronous and harmonious development.
PEMANFAATAN DANA BEASISWA KIP-K DALAM MENINGKATKAN PRESTASI BELAJAR MAHASISWA FKIP UNIVERSITAS MUHAMMADIYAH BENGKULU
Authors: Family Melza Okter , Yusuf Erwani , Ayuni Rossa 
Published: May 2024

Tujuan penelitian ini untuk melihat Pemanfaatan Dana Beasiswa KIP-K Dalam Meningkatkan Prestasi Belajar Mahasiswa FKIP Universitas Muhammadiyah Bengkulu. Jenis penelitian ini adalah deskriptif kualitatif dengan objek penelitian Beasiswa KIP-K Dalam Meningkatkan Prestasi Belajar Mahasiswa FKIP Universitas Muhammadiyah Bengkulu. Data dikumpulkan dengan cara observasi, wawancara dan dokumentasi. Teknik analisa data dilakukan melalui proses pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Untuk keabsahan data dalam penelitian ini dilakukan tringgulasi. Hasil penelitian menunjukan bahwa mahasiswa penerima beasiswa KIP-K sudah memanfaatkan dana beasiswa KIP-K tersebut untuk biaya hidup, membayar uang kuliah tunggal (UKT) dan keperluan kuliah seperti membeli makan sehari-hari, membayar kosan, membeli kuota, untuk transportasi dan membeli buku atau modul sebagai bahan untuk belajar yang tentu saja hal itu akan menunjang prestasi belajar mahasiswa. Disamping itu prestasi mahasiswa penerima beasiswa KIP-K juga mengalami peningkatan baik bidang akademik maupum bidang non akademik. Prestasi bidang akademik seperti mengikuti kegiatan kampus mengajar dan pertukaran mahasiswa kampus merdeka. Sementara itu adapun prestasi di bidang non akademik, seperti mengikuti kegiatan Bem Expo UMB 2023 ( juara 1 volly putri), kejuaraan daerah se-provinsi Bengkulu, porprov, popda, dan liga club se-provinsi Bengkulu.”
Revolutionizing Maritime Trade: Unveiling The Innovative Sea Toll Framework Through Advanced Livestock Folding Container Ship Science Mapping
Authors: Sutini  , Handajani Mudjiastuti , Ismiyati  
Published: May 2024

Objective: This study aims to trace the evolution of literature concerning sea tolls and livestock folding containers from 2014 to 2023, focusing on understanding research trends, sources, influential countries, author contributions, and major research areas.

Method: Utilizing the Crossref database, the study collected 1000 relevant publications related to sea tolls and livestock folding containers. A science mapping approach, assisted by VOSviewers, was employed for analysis.

Research Findings and Discussions: The analysis revealed several key findings. Firstly, it identified the emergence of sea tolls and livestock folding containers as significant research areas, indicating their growing importance. Secondly, the study identified dominant research topics and areas of interest, categorized into frequent, moderate, and rare levels. Additionally, it highlighted influential countries and sources contributing to the literature in this field. Furthermore, the study provided insights into author contributions and collaboration patterns, shedding light on the collaborative nature of research in this domain.

Research Implications: This study provides a comprehensive roadmap of current research directions in the fields of sea tolls and livestock folding containers. The findings of this study can guide future research endeavors, facilitate interdisciplinary collaboration, and inform policy decisions aimed at enhancing maritime transportation and economic development.

Originality/Value: The significance of this study lies in its comprehensive analysis of literature related to sea tolls and livestock folding containers, spanning a decade from 2014 to 2023. By employing a science mapping approach, the study offers a systematic overview of research trends and contributions in this field.
Research on the Willingness Model for Community Drug Rehabilitation Participation Based on Mixed Research
Authors: Chengyu Wang , Kakha Kuncharee , Khan Muhammad Shahid 
Published: May 2024

Objective: With the continuous improvement of community management functions, community drug rehabilitation management in China has also received increasing attention. Currently, research mainly focuses on the policy and measure reforms of management departments. According to relevant data, the willingness of drug users to actively participate in community drug rehabilitation management is still low.

Theoretical Framework: Through a search for quantitative data, it was discovered that two independent factors impact this variable: Program outcomes and small teamwork competence. Furthermore, there exists an additional mediating variable: Client-centered management practices have a correlation with program outcomes and have an impact on the willingness of clients. Client-centered management practice correlates with the proficiency of small workgroups and impacts clients' receptiveness.

Method: The researcher used qualitative and quantitative sequential exploratory mixed methods to achieve this. In the qualitative stage, the study focused on key stakeholders from five Correction Institutes using interviews, focus groups, and lessons learned as tools for data collection. A purposive sample of 27 individuals was selected. The researcher used content and topic analysis to develop a conceptual framework and a questionnaire. In the quantitative stage, the study included drug addicts in correction institutes. A sample of 356 respondents was sampled using a systematic sampling method.

Results and Discussion: Through literature research and field interviews, our project team found that customer centered management practices, small team cooperation ability, and the achievements of community management projects have an impact on the willingness of drug addiction patients to participate in community drug rehabilitation. Therefore, a structural equation model that affects the willingness to participate in community drug rehabilitation is proposed. We hope to explore the optimal structural relationship through a mixed qualitative and quantitative research method, and provide reference for relevant academic research.

Research Implications: As recommendations, managers should analyze project role links and emphasize cross-role communication and collaboration. For future studies, it is recommended to use qualitative data such as work process observations and examine the long-term consequences of participants' Willingness.