bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidencia ecológica de la relación de Croton draco var. draco Schltdl. & Cham. con hongos micorrizógenos
Authors: Olalde Portugal Víctor , Méndez Cortés Heriberto , Navarro Rodríguez Ana María Del Pilar , Ibarra Laclette Enrique , Ramón Farías Feliza 
Published: May 2024

Antecedentes: Existen reportes de que los Hongos Micorrizógenos Arbusculares (HMA) incrementan la producción de metabolitos secundarios en plantas medicinales. El género Croton ha sido poco estudiado en este aspecto. C. draco es una especie etnomedicinal, conocer la relación y naturaleza de los HMA, puede contribuir a obtener plantas en cultivo con mayor calidad y cantidad de metabolitos secundarios.
Preguntas: ¿Las raíces de C. draco pueden ser colonizadas por HMA? ¿Qué especies de HMA se encuentran en la rizósfera de C. draco? ¿La diversidad de especies de HMA varía dependiendo del ambiente?
Sitios de estudio y periodo de investigación: El estudio se hizo en tres localidades del estado de Veracruz, en el año 2019.
Métodos: Raíces terciarias de árboles adultos se procesaron y observaron al microscopio compuesto buscando esporas, hifas y arbúsculos de HMA. La diversidad y densidad esporas en la rizosfera de C. draco, se determinó en muestras de suelo, comparando tres sitios de estudio. Los datos se normalizaron y se hicieron pruebas paramétricas.
Resultados: Se observaron esporas, hifas y arbúsculos en las raíces de C. draco. La abundancia de esporas y diversidad de HMA fue diferente entre los sitios evaluados. Con base en la morfología de las esporas se reconocieron 14 taxones, de los cuales, solo dos están presentes en los tres sitios.
Conclusión: C. draco presentó en sus raíces estructuras propias de los HMA. Basado en los resultados concluimos que las condiciones ambientales influyen en la abundancia de esporas y en la diversidad de especies de HMA.
An assessment of federal alcohol policies in Canada and priority recommendations: Results from the 3rd Canadian Alcohol Policy Evaluation Project
Authors: Farkouh Elizabeth K. , Vallance Kate , Wettlaufer Ashley , Giesbrecht Norman , Asbridge Mark , Farrell-Low Amanda M. , Gagnon Marilou , Price Tina R. , Priore Isabella , Shelley Jacob , Sherk Adam , Shield Kevin D. , Solomon Robert , Stockwell Tim R. , Thompson Kara , Vishnevsky Nicole , Naimi Timothy S. 
Published: May 2024

Abstract
Objective
To systematically assess the Canadian federal government’s current alcohol policies in relation to public health best practices.

Methods
The 2022 Canadian Alcohol Policy Evaluation (CAPE) Project assessed federal alcohol policies across 10 domains. Policy domains were weighted according to evidence for their relative impact, including effectiveness and scope. A detailed scoring rubric of best practices was developed and externally reviewed by international experts. Policy data were collected between June and December 2022, using official legislation, government websites, and data sources identified from previous iterations of CAPE as sources. Contacts within relevant government departments provided any additional data sources, reviewed the accuracy and completeness of the data, and provided amendments as needed. Data were scored independently by members of the research team. Final policy scores were tabulated and presented as a weighted overall average score and as unweighted domain-specific scores.

Results
Compared to public health best practices, the federal government of Canada scored 37% overall. The three most impactful domains—(1) pricing and taxation, (2) marketing and advertising controls, and (3) impaired driving countermeasures—received some of the lowest scores (39%, 10%, and 40%, respectively). Domain-specific scores varied considerably from 0% for minimum legal age policies to 100% for controls on physical availability of alcohol.

Conclusion
Many evidence-informed alcohol policies have not been adopted, or been adopted only partially, by the Canadian federal government. Urgent adoption of the recommended policies is needed to prevent and reduce the enormous health, social, and economic costs of alcohol use in Canada.
Fala Feito Homem, Rapaz!
Authors: Dos Santos Diego Mateus , De Miranda José da Cruz Bispo 
Published: May 2024

O artigo presente é um empreendimento que tem por intenção identificar, por referências empírica e bibliográfica, as possibilidades de diversificação nas leituras e práticas das masculinidades negras no Brasil contemporâneo diante de imposições sexistas e racistas de performances de gênero na ordem social lida, a partir do método interseccional, cruzando marcadores de classe, raça e gênero para uma concepção ampla sobre o que significa ser homem negro no tempo-espaço em questão. A partir de conceitos como afrodiáspora e atlântico negro em Gilroy (2001), ponto de vista privilegiado, referenciados em Conrado e Ribeiro (2017), autoetnografia, com bases em Fortin (2017) e Miranda (2022), avenidas identitárias e encruzilhada analítica, partindo de Akotirene (2019), se estabelece um diálogo entre teoria e experiência a fim de uma maior elucidação da problemática in loco.
Peran Kualitas Laba Terhadap Nilai Perusahaan: Komisaris Independen dan Kualitas Audit sebagai Variabel Pemoderasi
Authors: Diana Pauline Arum , Pamungkas Imang Dapit 
Published: May 2024

The company aspires to generate profits so that the firm value becomes high and shareholders can experience prosperity. In achieving this goal, investors typically rely on experienced individuals, such as a commissioner. Investors also tend to trust companies audited by the KAP. This research aims to test and analyze the quality of profits affecting the firm value as well as the audit quality and independent commissioners as a moderation variable. The application used to analyze the data in this study is Warpls 7.0. The population includes all property and real estate companies from 2020 to 2022, with purposive sampling yielding a sample of 122 data over three years. The implications of this research are achieving profits and increasing firm value, placing trust in commissioners, and recognizing the quality of financial reports audited by KAP. The results indicate that quality profits have a stimulating effect on a firm value. Independent commissioners cannot moderate the relationship between the quality of profits and firm value, while audit quality can moderate this relationship.
Keywords: Independent Commissioners, Profits, Firm Value, Audit Quality
La démarche ePortfolio : d’un outil de publication numérique créative vers un dispositif d’entraide entre pairs
Authors: Daniel Catherine , Thireau Katell 
Published: May 2024

L’article présente un dispositif pédagogique mis en place en « DU Assistant des bibliothèques et de documentation » en 2015 pour répondre aux évolutions du secteur professionnel. L’équipe pédagogique a mené une étude en 2022 sur les usages de l’ePortfolio à partir d’un corpus de productions d’étudiants et une enquête. Celle-ci porte à la fois sur la structuration de l’outil, la création et le partage de contenus.Les hypothèses de départ laissent penser que la création de l’ePortfolio permet de monter en compétences dans le domaine de la publication numérique, de la valorisation et de la médiation numériques, en particulier en lien avec les collections de littérature.Nos résultats montrent que l’ePortfolio offre l’occasion pour les étudiants de développer une forme de créativité et d’écriture de soi, notamment en élaborant des contenus non prescrits. Il amène à encourager l’entraide entre étudiants par le partage des contenus via un service web. Outil personnel de valorisation de son parcours, il devient ainsi un outil de partage d’expérience.Comment la démarche ePortfolio, par la publication de contenus numériques créatifs, permet-elle de développer des compétences douces et de favoriser l’entraide entre pairs ?
The Influence of Knowledge about Anemia, Dates, and Iron Tablets on Hemoglobin Levels in Prospective Pregnant Women at South Klaten Community Health Center
Authors: Yulaikah Siti , Kuswati Kuswati 
Published: May 2024

<p><strong>Background</strong>: Anemia, commonly known as a deficiency in blood, influences individual behavior. Higher knowledge about anemia before conception correlates with a greater awareness of nutritional needs. Preventing anemia in preconception women involves iron tablet consumption, while dates serve as an alternative means to prevent anemia. This study aims to ascertain the influence of anemia knowledge, date consumption, and iron tablet intake on hemoglobin levels among prospective pregnant women at the Klaten Selatan Community Health Center. This research heald on January to September 2023 in the operational area of the Klaten Selatan Community Health Center.</p><p><strong>Methods</strong>: This research adopts a pre-experimental design employing a one- group pretest-posttest study. Purposive Random Sampling method is used, encompassing 40 research subjects. The dependent variable is hemoglobin levels, while the independent variables are knowledge about anemia, date consumption, and iron tablets. Data collection involves primary data through questionnaire responses and observation sheets. Research analysis includes univariate analysis, bivariate analysis utilizing the Spearman Rho test for knowledge variables and the Friedman test for date and iron tablet consumption variables. <strong>Results</strong>: There is a significant impact of knowledge about anemia (p = 0.000), date consumption (p = 0.0094), and iron tablet intake (p = 0.0073) on hemoglobin levels among prospective pregnant women.</p><p><strong>Conclusion</strong>: Knowledge about anemia influences hemoglobin levels, and there is an increase in hemoglobin levels after consuming dates and iron tablets among prospective pregnant women at the Klaten Selatan Community Health Center.</p><p> </p><p><strong>Keywords</strong>: <em>Knowledge, Dates, Iron Tablets, Hemoglobin Levels</em></p><p><strong> </strong></p>
Gut commensals require Peyer’s patches to induce protective systemic IgA responses
Authors: Wilmore Joel , Harris Joshua , Zoccoli-Rodriguez Victoria , Delaney Mara , Cruz Tania , Guadette Brian 
Published: May 2024

Abstract

Gut educated IgA secreting plasma cells that disseminate beyond the mucosa and into systemic tissues have been described as providing beneficial effects from disease in several contexts. Several bacteria have been implicated in the induction of systemic IgA, however the mechanisms that result in differential levels of induction by each bacterial species are still unknown. Here we show, the commensal bacteria, Bacteroides fragilis (Bf), is an efficient inducer of systemic IgA responses. The ability of Bf to induce the production of bone marrow IgA plasma cells and high levels of serum IgA relied on high levels of gut colonization in a dose-dependent manner. Colonization induced Bf-specific IgA responses were severely diminished in the absence of Peyer’s patches, but not the murine cecal patch. Colonization of mice with Bf, a natural human commensal, resulted in few changes within the microbiome and the host transcriptional profile in the gut, suggesting a commensal relationship with the host. Bf colonization did benefit the mice by inducing systemic IgA that led to increased protection in a bowel perforation model resulting in lower peritoneal abscess formation. These findings demonstrate a critical role for bacterial colonization and Peyer’s patches in the induction of robust systemic IgA responses that confer protection from bacterial dissemination outside of the gut.
Analysis of 16S rRNA amplicon data illuminates the major role of environment in determining the marine plastisphere microbial communities
Authors: Ramakodi Meganathan P. , Saravanan Palanivishwanath 
Published: May 2024

Abstract

Microplastics (MPs) are a potential threat to the marine environment and its associated ecosystem functions. Earlier investigations revealed that the microbiome plays a crucial role in deciding the fate of MPs in the environment. Further studies also highlighted the influences of environment and polymer types on the plastisphere microbiome. Nevertheless, the major factor that determines the plastisphere microbiome remains elusive. Thus, we examined the publicly available marine plastisphere data generated from polyethylene (PE), polypropylene (PP), and polystyrene (PS), collected from three different locations to identify the importance of environment and /or polymer types in shaping the microbiome. The beta diversity analyses showed a clear distinction between samples collected from different locations. The PERMANOVA results illustrated a significant influence of environment and sample type (control/PE/PP/PS) on the microbial communities. However, the influence of sample type on microbial diversity was not significant (P-value>0.05) when the control samples were removed from the dataset but the environment remained a significant factor (P-value<0.05). Further, the differential abundance analyses explicitly showed the abundance of several taxa to be significantly influenced (adjusted P-value<0.05) by the locations than the polymer types. Thus, this study suggests that both the surrounding environment and polymer types determine the microbial communities on marine MPs but the role of environment in shaping the microbial composition is greater than that of polymer types.
GATA1: A Key Biomarker for Predicting the Prognosis of Patients With Diffuse Large B- cell Lymphoma
Authors: Zhang Yuxin , Wang Yue , Wang Shifen , Cui Dawei , Wei Zheng 
Published: May 2024

Abstract

Background
Diffuse large B-cell lymphoma (DLBCL) is a common and highly aggressive type of lymphoma. Iron metabolism plays a critical role in human diseases, however, which remains completely unclear in patients with DLBCL. The aim is to explore the genetic characteristics and molecular mechanisms underlying iron metabolism in patients with DLBCL.
Methods
Based on the Gene Expression Omnibus (GEO) and the GeneCards database, weighted gene co-expression network analysis (WGCNA) was performed on the DLBCL sample (GSE83632) and Iron metabolism-related datasets. Enrichment analysis(GO/KEGG enrichment analysis and GSEA enrichment analysis) was used to screen the key gene and analyze its expression and possible mechanism of action in patients with DLBCL. The quantitative real-time PCR (qRT-PCR) was used to verify the expression of GATA1 gene.
Results
GATA-binding factor 1 (GATA1), as a key gene of iron metabolism in DLBCL patients, was related to the myeloid cell differentiation and granulocyte differentiation pathways to affect CD4+ T cells, B cells, and monocytes. GATA1 was strongly positively correlated with sensitivity to multiple targeted drugs including imatinib, nilotinib, and crizotinib, but negatively correlated with the PI3K and CDK9 inhibitors. The patients with high GATA1 expression had higher overall survival and better prognosis than the patients with low expression. Additionally, high expression of GATA1 gene was confirmed in DLBCL patients by qRT-PCR analysis.
Conclusions
GATA1 as one of the important genes of iron metabolism suggested a significant biomarker for predicting the prognosis of DLBCL patients.
Revealing the intricacies: A comprehensive study of the CARD14 gene in Psoriatic patients of Indian descent
Authors: Singh S. , Pradhan D. , Puri P. , Sharma Shruti , Jain A. K. 
Published: May 2024

Abstract

Several Genome Wide linkage Studies on psoriasis performed to gain insight of genetic architecture of the disease. Caspase Recruitment Domain-containing family 14 (CARD14) also known as CARMA2 or BIMP2; cytogenic location: 17q25.3, is a scaffold protein that primarily controls the skin epidermis’s nuclear factor kB (NF-kB) signaling pathway activity in skin epidermis, a master gene for inflammation, has been shown to be linked with rare, heritable form of psoriasis. CARD14 is predominantly expressed in keratinocytes and epithelial cells, but also in unidentified dermal cells. For better understanding of molecular processes involved in CARD14 underlying Indian psoriatic patients, we analyzed gene expression of 42 moderates to severe cases of plaque psoriasis and same number of controls using qPCR and its validation through Immunohistochemistry (IHC). This study identifies that the expression of CARD14 in dermal endothelial cells among patients with psoriasis and explores the potential functional consequences associated with an overactive CARD14 gene. Furthermore, the expression data from the western population was consistent with the results of the qPCR validation of the candidate gene. There is a significant correlation between Indian psoriasis vulgaris patients and CARD14 up-regulation, as evidenced by a roughly two-fold shift in lesional tissue expression. This provides insights into the pathways and genes linked to the pathogenesis of psoriasis.
Exploring Adaptive Strategies and Resilience to Drought Stress Across Diverse Populations of Sporobolus Ioclados in the Cholistan Desert
Authors: Rehman Abdul , Memon Rabia Asma , Hameed Mansoor , Naz Nargis , Shah Anis Ali , Gatasheh Mansour K. , Shaffique Shifa , Abbas Toqeer 
Published: May 2024

Abstract

The present research was carried out at the Khawaja Fareed Government College, Rahim Yar Khan, Pakistan, to check the drought tolerance mechanisms of fifteen distinct ecotypes of Sporobolus ioclados. These ecotypes were cultivated using regular nursery techniques, and then exposed to four different degrees of drought in a carefully monitored experimental setting. The experiment's two-factorial arrangement of populations and drought treatments was performed three times to achieve statistical significance. Sporobolus ioclados's plant height, number of roots, flag leaf area, stomatal features, and proline concentration all varied significantly as a result of the plant's physiological and morphological responses to drought stress. A mixture of statistical methods, including ANOVA, PCA, HCA, and DFA, offered a thorough knowledge of the plant's adaptation processes and the level of ecotype diversity within the species. Drought stress caused significant changes in morphological and physiological features, and proline content was negatively correlated with photosynthetic activity, indicating that proline protects against drought. Sporobolus ioclados populations have varied adaptation strategies, and the species' potential for afforestation in dry environments was shown using PCA and DFA analysis. This work significantly contributes to climate change research and ecosystem conservation by revealing drought-tolerant plants for desert places.
Aerial Image Analysis of Changes in Wetlands between 2019 and 2023 in the Barataria and Breton Sound Basins of Coastal Louisiana
Authors: Potter Christopher 
Published: May 2024

Abstract

Loss of marshlands in the Mississippi Delta plain of Louisiana threatens the future of the region’s economy, one which is heavily reliant on coastal wetland resources. This study builds on previous remote sensing investigations over the Barataria and Breton Sound Basins to make increasingly detailed assessments of changes occurring in coastal wetlands of southern Louisiana from both human extractive activities and repeated hurricanes. Analysis over the past four years (2019 to 2023) using NDWI from aerial image acquisitions revealed that there has been a widespread increase in relatively deep-water coverage (and corresponding losses of marshland coverage) since 2019 over most of the Barataria and Breton Sound Basins. Scouring of formerly shallow water cover and widespread erosion of brackish and fresh marshland shorelines followed the storm surges of Hurricanes Zeta (2020) and Ida (2021). Heightened fragmentation of marshland edges and interior pond features based on patch metric analysis implied that different types of damage inflicted on coastal wetlands of southeastern Louisiana from tropical storms can be characterized using aerial remote sensing.
Halofantrine up-regulates ATP6V0D2 mediating cytotoxic autophagy in glioblastoma and its mechanism
Authors: Huang Ni , Chen Wei , Tang Ke , Liu Guoqi 
Published: May 2024

Abstract

Background
Halofantrine is a drug used to treat malaria, and recent studies have shown that it has potential to treat glioblastoma.
Objective
To study the inhibitory effect of Halofantrine on glioblastoma and its mechanism.
Methods
Based on GEO database and clinical samples, the expression difference of ATP6V0D2 gene in glioblastoma was detected. The inhibitory effect of Halofantrine on U251 cells and the expression of ATP6V0D2 gene and autophagy protein at gene and protein levels were detected in vitro. The importance of ATP6V0D2 gene was verified by constructing stable overexpression and overexpression model of ATP6V0D2 gene in U251 cells. The inhibitory effect and mechanism of Halofantrine on axillary tumor model in nude mice were verified in vivo.
Results
ATP6V0D2 gene was expressed in low level in glioblastoma patients. Halofantrine up-regulates ATP6V0D2 gene mediated U251 cytotoxic autophagy. After ATP6V0D2 knockdown, Halofantrine-mediated cytotoxic autophagy of U251 was inhibited, while overexpression was reversed. In addition, Halofantrine has a good anti-GBM effect in vivo, and its mechanism of action is consistent with in vitro experiments.
Conclusion
Halofantrine can mediate toxic autophagy of U251 cells through up-regulation of ATP6V0D2. ATP6V0D2 is a key tumor suppressor gene in glioblastoma.
Detection of the Mild Myocardial Injury during Percutaneous Coronary Intervention Using Evaluation of Minor Changes on Electrocardiogram and Heart Rate Variability
Authors: Chaikovsky Illya , Dziuba Dmytro , Kryvova Olga , Chumachenko Dmytro , Todurov Boris , Loskutov Oleg 
Published: May 2024

Abstract

Background
As cardiovascular mortality continues to increase globally, Percutaneous Coronary Intervention (PCI) with stent placement stands out as a cutting-edge and highly effective treatment for severe cardiovascular diseases. However, the inherent invasiveness of any endovascular procedure introduces the risk of coronary vessel and myocardial damage. This study aimed to evaluate the utility of a novel electrocardiographic metric for detecting subtle myocardial injuries after coronary stenting.
Materials and Methods
This investigation was conducted in 2021 at the Kyiv Heart Institute of the Ministry of Healthcare of Ukraine. The study involved 23 patients who underwent PCI, each subject to a meticulous preoperative examination. A paired measurement approach was employed, encompassing 3-minute ECG recordings both before and several hours after the operation, using a compact ECG device. Each pair of electrocardiograms underwent thorough analysis, scrutinizing 240 primary and computed ECG parameters.
Results
The analysis delineated a distinct subgroup that exhibited significant myocardial damage after stenting. This subgroup was characterized by an older average age and more stents than their counterparts. Notably, a concurrent reduction in the psychoemotional state index was observed alongside ECG alterations in these patients, suggesting a correlation between myocardial damage and psychoemotional distress.
Discussion
The introduction of a new electrocardiographic index has illuminated the subtle myocardial damage incurred during PCI. The findings of this study underscore the complex interplay between physical cardiac trauma and psychological stress, highlighting the importance of a comprehensive approach to post-PCI patient assessment.
Conclusions
The newly devised electrocardiographic metric proved to be a significant advancement in the early detection of myocardial damage after PCI. The metric's ability to capture not only physiological but also psychoemotional changes is a pivotal step toward more integrative post-operative patient care, paving the way for enhanced recovery protocols and personalized treatment strategies in interventional cardiology.