bluuebunny/crossref_metadata_2025_split huggingface dataset:
From clicks to credits: examining the influence of online engagement and internet addiction on academic performance in Chinese universities
Authors: Jiang Yongzhong , Joshi Dirgha Raj , Khanal Jeevan 
Published: June 2024

AbstractUniversity students’ engagement in online activities can impact both internet addiction and academic performance. This research aims to investigate these effects among university students. Using data from the "China College Students Longitudinal Survey" conducted by the Chinese Academy of Social Sciences between 2013 and 2018, this study examines the influence of university students’ engagement in online activities. With a sample size of 15,102 university students, we explored the relationship between online activity, internet addiction, and academic performance. Employing stratified random sampling, the study investigates sample characteristics, including gender, study level, time spent online, and experiences accessing websites. Academic performance is assessed through six categories, employing descriptive and inferential statistics such as t-tests, ANOVA, stepwise linear regression, and path analysis. The findings indicate significantly high levels of university students’ engagement in online activities, accompanied by a high prevalence of internet addiction. Key factors determining university students’ engagement, internet addiction, and academic performance include gender, study level, time spent online, and experiences accessing websites beyond the Great Firewall. The study establishes a complex relationship, revealing negative effects of specific online engagements on internet addiction, while the latter influences university students’ engagement. Overall, this research contributes valuable insights into the intricate interplay between online behaviors, addiction, and academic performance among Chinese university students, with implications for educational policies and interventions.
3D-visualization of segmented contacts of directional deep brain stimulation electrodes via registration and fusion of CT and FDCT
Authors: Al-Jaberi Fadil , Moeskes Matthias , Skalej Martin , Fachet Melanie , Hoeschen Christoph 
Published: June 2024

Abstract
Objectives
3D-visualization of the segmented contacts of directional deep brain stimulation (DBS) electrodes is desirable since knowledge about the position of every segmented contact could shorten the timespan for electrode programming. CT cannot yield images fitting that purpose whereas highly resolved flat detector computed tomography (FDCT) can accurately image the inner structure of the electrode. This study aims to demonstrate the applicability of image fusion of highly resolved FDCT and CT to produce highly resolved images that preserve anatomical context for subsequent fusion to preoperative MRI for eventually displaying segmented contactswithin anatomical context in future studies.

Material and methods
Retrospectively collected datasets from 15 patients who underwent bilateral directional DBS electrode implantation were used. Subsequently, after image analysis, a semi-automated 3D-registration of CT and highly resolved FDCT followed by image fusion was performed. The registration accuracy was assessed by computing the target registration error.

Results
Our work demonstrated the feasibility of highly resolved FDCT to visualize segmented electrode contacts in 3D. Semiautomatic image registration to CT was successfully implemented in all cases. Qualitative evaluation by two experts revealed good alignment regarding intracranial osseous structures. Additionally, the average for the mean of the target registration error over all patients, based on the assessments of two raters, was computed to be 4.16 mm.

Conclusion
Our work demonstrated the applicability of image fusion of highly resolved FDCT to CT for a potential workflow regarding subsequent fusion to MRI in the future to put the electrodes in an anatomical context.
Using predatory species and entomopathogenic fungi as alternatives to chemical pesticides in green bean field
Authors: Kamel Hamzah M. , Eid Aziza E. , Nouh Gehan M. , Adly Dalia 
Published: June 2024

Abstract
Background
Green bean, Phaseolus vulgaris L. (Fam.: Leguminosae) is a widely consumed grain legume prized for its edible seeds and pods. It is susceptible to infestations with various pests as insects and mites throughout the growing season. In this study, the efficacy of the predatory species, Chrysoperla carnea (Stephens), Phytoseiulus persimilis Athias-Henriot and the entomopathogenic fungus (EPF) Metarhizium anisopliae (Hypocreales: Clavicipitaceae), as well as conventional pesticides, Mospilan and Vertimec, were evaluated against the most important pests, mainly the whitefly, Bemisia tabaci (Genn.) and the two-spotted spider mite, Tetranychus urticae Koch, infesting the green beans cultivated at two locations Giza and El-Menoufia Governorates in Egypt.

Results
The findings demonstrate that treatments using C. carnea and M. anisopliae effectively reduced the whitefly population, while pesticide treatments were comparatively less effective. In the Giza plots, at the end of the experiments, the use of both M. anisopliae and C. carnea showed high reductions in whitefly population (85.57 and 84.87%), respectively, while in El-Menoufia, C. carnea (97.74%) was the most effective treatment followed by M. anisopliae (90.32%). Pesticide treatment in this case yielded a reduction rate of (22.76 and 59.67%) in Giza and El-Menoufia plots, respectively. However, for spider mite control, P. persimilis proved to be the most effective treatment in Giza and El-Menoufia plots, reducing the spider mite population to 98.44 and 96.14%, respectively. Metarhizium anisopliae treatment also displayed moderate effectiveness, with reduction rates of 75.62 and 75.37% in Giza and El-Menoufia plots, respectively. In comparison, pesticide treatment showed low effectiveness, with reduction rates of only 23.92 and 53.16% in the two locations, respectively.

Conclusion
Applications of the predator, C. carnea and the EPF, M. anisopliae were highly effective in reducing the population of whitefly, while the predator mite P. persimilis proved to be the most effective for controlling the spider mites. Overall, the study suggests that biocontrol agents, such as the predators and the EPF, can be considered as alternatives to synthetic chemical pesticides for controlling pests infesting green beans.
Nutritional effect on lipoproteins and their subfractions in patients with Psoriatic Arthritis: a 12-week randomized trial—the DIETA trial
Authors: Scherer Daniele , Leite Beatriz Figueiredo , Morimoto Melissa Aparecida , Oliveira Thauana Luiza , Klemz Barbara N. Carvalho , Freitas Rosana A. M. Soares , Pappiani Caroline , Damasceno Nágila R. Teixeira , Pinheiro Marcelo de Medeiros 
Published: June 2024

Abstract
Introduction
Patients with psoriatic arthritis have some lipid metabolism changes and higher risk of metabolic syndrome (MetS) and cardiovascular diseases, regardless of traditional risk factors, suggesting that chronic inflammation itself plays a central role concerning the atherosclerosis. However, there is a lack of information regarding atherogenic pattern and lipoprotein subfractions burden in these individuals.

Aim
To evaluate the HDL and LDL-cholesterol plasmatic levels and their subfractions after a nutritional intervention in patients with psoriatic arthritis (PsA).

Methods
This was a randomized, placebo-controlled clinical trial of a 12-week nutritional intervention. PsA patients were randomly assigned to 1-Placebo: 1 g of soybean oil daily, no dietetic intervention; 2-Diet + Supplementation: an individualized diet, supplemented with 604 mg of omega-3 fatty acids, three times a day; and 3-Diet + Placebo: individualized diet + 1 g of soybean oil. The LDL subfractions were classified as non-atherogenic (NAth), atherogenic (Ath) or highly atherogenic (HAth), whereas the HDL subfractions were classified as small, medium, or large particles, according to the current recommendation based on lipoproteins electrophoresis.

Results
A total of 91 patients were included in the study. About 62% of patients (n = 56) had an Ath or HAth profile and the main risk factors associated were male gender, longer skin disease duration and higher BMI. Thirty-two patients (35%) had a high-risk lipoprotein profile despite having LDL plasmatic levels below 100 mg/dL. The 12-week nutritional intervention did not alter the LDL subfractions. However, there were significant improvement of HDL subfractions.

Conclusion
Recognizing the pro-atherogenic subfractions LDL pattern could be a relevant strategy for identifying PsA patients with higher cardiovascular risk, regardless total LDL plasmatic levels and disease activity. In addition, a short-term nutritional intervention based on supervised and individualized diet added to omega-3 fatty acids changed positively the HDLLARGE subfractions, while LDLLARGE subfraction was improved in hypercholesterolemic individuals.
ClinicalTrials.gov identifier: NCT03142503 (http://www.clinicaltrials.gov/).
Standardized observation of temperament in Lebanese toddlers using the laboratory temperament assessment battery (Lab-TAB)
Authors: Shamseddeen W. , Safieddine B. , Mohsen H. , Akoury Dirani L. 
Published: June 2024

Abstract
Background
Temperament is the difference between individuals’ emotional and behavioral responses to diverse external events. It is a complex interplay between genetic and environmental factors. Hence, the need to assess temperament objectively and better understand its impact on developmental and interpersonal outcomes. Measuring temperament in early childhood can be challenging since parents will report their subjective perceptions about their toddlers. While surveys are quick instruments that require less clinical involvement, standardized laboratory assessments secure a relatively high level of objective observation. Since no published studies were conducted in Arab countries, the current research focuses on examining temperament in a sample of twenty mother-toddler dyads using the Laboratory Temperament Assessment Battery (Lab-TAB) locomotor version.
Interrater reliability and validity were assessed. Higher-order temperament components were determined by principal component analysis. T test and one-way ANOVA examined the association between demographics and temperament components.

Results
The retained variables ranged between fair (> 0.43) and good (< 0.98) for all Lab-TAB episodes. Three higher-order temperament components were obtained. Age was significantly negatively correlated with Lab-TAB Fear dimension, r = − .47, p > .05, and Lab-TAB temperament component 3, r = .45, p > .05. Male toddlers (M = .55, SD = 1.055) had significantly higher levels of temperament component 3 compared to female (M = − .45, SD = .718), t(18) = 2.52, p < .05. There was a significant effect of time spent with mother on temperament component 3, F(2,17) = 7.01, p < .05.

Conclusion
After exploring the temperament factor structure, we found that the Lab-TAB locomotor version was a valid tool to be used to observe temperament in toddlers living in Lebanon, a Middle Eastern culture. Some gender significant differences would deserve deeper exploration in future research. A replication of this study would also strengthen its findings.
Preliminary results from FLAGSHP-1: A phase 1 study of ERAS-601 as a monotherapy or in combination with cetuximab in patients (pts) previously treated for advanced chordoma.
Authors: Gounder Mrinal M. , Rosen Ezra , Parikh Aparna Raj , Conley Anthony Paul , Hong David S. , Sheth Siddharth , Mai Nicholas , Sgroe Erica , Mitchell Ryan , Picard Roxana , Brail Les H. , Cote Gregory Michael 
Published: June 2024

11522 Background: SHP2 is an oncogenic tyrosine phosphatase that transduces receptor tyrosine kinase signaling in the RAS/MAPK pathway via phosphatase-mediated regulation of guanine nucleotide exchange factors. SHP2 signaling has recently been identified as a genetic dependency for chordoma, a rare tumor type with no approved therapies (1), and preclinical studies with SHP2 inhibitors have demonstrated activity in chordoma models. Methods: As part of the FLAGSHP-1 study, patients (pts) with advanced or metastatic chordoma were enrolled in either the monotherapy or cetuximab combination cohort to assess the safety, tolerability, PK, and preliminary clinical activity of ERAS-601. Chordoma pts previously treated with an EGFR inhibitor were allowed to enroll. Results: As of 31 Oct 2023, a total of 11 pts with previously treated advanced or metastatic chordoma received ERAS-601. Two pts received ERAS-601 as monotherapy: one at 40 mg BID (continuous) and the other at 80 mg TIW (three times a week). An additional 9 pts received the combination of ERAS-601 (40 mg BID 3 weeks on and 1 week off every 28 days [3/1]) in combination with cetuximab (500 mg/m2 Q2W). The treatment-emergent adverse events (TEAEs) occurring in >20% of pts (Grade [Gr] 1-2 unless noted) were: dermatitis acneiform (2 pts-Gr 3), paronychia, dry skin, skin fissures, skin infection (1 pt-Gr. 3), diarrhea, nausea, vomiting, stomatitis, peripheral oedema, fatigue, thrombocytopenia, and AST elevation. No patients discontinued therapy due to TEAEs related to ERAS-601. Out of the 9 pts receiving the combination of ERAS-601 and cetuximab, by RECIST 1.1 there was 1 PR and 8 pts with a best response of SD. Of the 8 pts who had a best response of SD, 7 had some tumor shrinkage. The median time on combination treatment was 5.06 months, with 8 out of 9 pts remaining on the study. Conclusions: The most common toxicities observed for the ERAS-601 + cetuximab combination were dermatologic, which were reversible. Encouraging preliminary activity was seen in advanced, refractory chordoma. 1. Sharifina et al., 2023, Nat. Commun. Clinical trial information: NCT04670679 .
Integrated multi-omics analysis reveals immune landscape of tertiary lymphoid structure in retroperitoneal liposarcoma.
Authors: Tao Ping , Wang Zhenyu , Wang Jiongyuan , Chen Jun , Hong Liang , Ma Lijie , Zhang Yong , Tong Hanxing 
Published: June 2024

11563 Background: Retroperitoneal liposarcoma (RPLS) is a rare type of mesenchymal tumor characterized by difficult surgical management, immune desert, poor response to immunotherapy and high local recurrence rate. However, how tertiary lymphoid structures (TLS) dictates complex biological processes such as antitumor immunity remains unknown. Thus, we aimed to investigate the spatio-temporal heterogeneity of TLS formation, maturation, and functional involvement in TIME, and the clinical value of TLS in multiple retrospective RPLS clinical cohorts. Methods: 330 patients were retrospectively enrolled into five independent cohorts from the two largest retroperitoneal tumor research centers in China and the TCGA database. Single-cell RNA sequencing (sc-RNA seq) (n=4) and spatial transcriptome seq (n=2) were performed for the estimation of TIME based on treatment-naive RPLS. Transcriptomic profiles of 309 cases in five cohorts were obtained from the ZSFD, GEO, and TCGA databases. TLS was quantified in three different anatomic subregions (intra-tumor, invasion margin and peri-tumor) and correlated with overall survival (OS) and disease-free survival (DFS) by Cox regression and Kaplan-Meier analysis. Multiplex immunohistochemistry (mIHC) was performed to characterize and validate the spatial composition of TLS in another treatment-naive RPLS cohort (n=16), neoadjuvant chemotherapy (n=12) and neoadjuvant radiotherapy (n=20) RPLS cohorts. Results: The joint scoring system of T and P scores stratified RPLS into four immune classes with different TLS distribution patterns and prognoses (p<0.001). The immune class C-index was significantly higher than the TNM staging system (0.798 vs. 0.62, p=0.005). Importantly, mIHC revealed that regulatory T cells (Tregs) and M2 phenotype tumor-associated macrophages (TAMs) were significantly increased in intra-tumoral TLS in DDLPS compared to WDLPS, showing an immunosuppressive pattern. Strikingly, neoadjuvant chemotherapy and radiotherapy could block this status of immunosuppressive, induced TLS formation and restore the antitumor immune balance with significantly more CD38+IgG+ plasma cells (PCs) in responsive RPLS, whereas non-responsive RPLS deteriorated into a more suppressive one. Sc-RNA Seq and ST analysis further revealed significant intra- and inter-tumoral TIME heterogeneity and identified the underlying transcriptomic programs driving each phenotype. Conclusions: Our study provides a high-resolution map of TIME in treatment-naive and neoadjuvant chemotherapy/radiotherapy RPLS. Effective neoadjuvant chemotherapy and radiotherapy can induce TLS formation and restore the antitumor immune balance in RPLS.
Analyzing the effect of treatment modalities on survival in synovial sarcoma.
Authors: Samuel Maya Mary , Saldhi Prachi , Silberstein Peter T. , Chaddha Jasleen Kaur 
Published: June 2024

11570 Background: Synovial sarcoma (SS) is a rare, slow growing, and aggressive soft tissue sarcoma that commonly affects young adults, with a diagnosis at an average age of 30 years. It usually originates near the joints of the extremities and presents as a painless lump. Metastasis to the regional lymph nodes and lungs is common. SS is proposed to be a result of a chromosomal translocation leading to the fusion of SYT and SSX genes. Standard treatment is tumor resection followed by adjuvant therapy. No study has compared the effects of different surgery and adjuvant therapy types on overall survival. This study will compare the effects of various therapeutic modalities on overall survival for patients with SS. Methods: The National Cancer Database (NCDB) was used to identify patients diagnosed with SS from 2004 to 2020 using histology code 9040 as assigned by the Commission on Cancer Accreditation program. Kaplan-Meier, ANOVA Chi-Square, and Logistic Regression tests were performed, and data were analyzed using SPSS version 29. Statistical significance was set at α = 0.05. Results: The sample retrieved from NCDB consisted of 2566 patients with SS. Of these 2566 patients, 1962 patients (76.5%) received surgery at the primary site. The receipt of surgery was associated with a marked increase in survival (132.2 months vs. 48.6 months, p<0.001). Out of the surgical patients, 883 patients (45.0%) received a lobectomy, 696 patients (35.5%) received a wedge segmental resection, 21 patients (1.07%) received an extended lobectomy and 1 patient (0.05%) received a hepatectomy. Patients who underwent lobectomy and wedge/segmental resections had improved outcomes compared to patients who received other types of surgery (p<0.001). In addition, 898 patients (45.8%) received adjuvant chemotherapy, 38 patients received adjuvant chemoradiation (1.94%), and 22 patients received adjuvant radiation (1.12%). The receipt of adjuvant chemotherapy was associated with better outcomes than receiving no adjuvant therapy (121.9 months vs. 108.4 months, p<0.001). The receipt of adjuvant chemoradiation was also associated with better outcomes than receiving no adjuvant therapy (132.2 months vs. 108.4 months, p=0.023). The receipt of adjuvant chemotherapy versus adjuvant chemoradiation is not significantly different in regard to overall survival. Conclusions: This study confirms that receiving surgery for SS is associated with markedly increased overall survival. Furthermore, wedge/segmental resections and lobectomies are associated with improved outcomes compared to other types of surgery. Receiving adjuvant therapy is associated with improved outcomes as compared to the receipt of surgery alone. Adjuvant chemotherapy and adjuvant chemoradiation are associated with better outcomes than adjuvant radiation alone. Further studies are needed to understand the factors involved in choosing specific treatment modalities for SS.
A phase II study of an oncolytic herpes simplex virus 2 and an anti-PD-1 antibody in patients with advanced sarcoma.
Authors: Tan Zhichao , Liu Jiayong , Gao Tian , Ding Sijuan , Han Liang , Luo Suxia , Fan Qingxia , Shi Jianhua , Gu Xiangyong , Liu Binlei , Alevizopoulos Nassos , Fan Zhengfu , Huang Jing 
Published: June 2024

11571 Background: OH2 is an attenuated oncolytic Herpes Simplex-2 Virus expressing GM-CSF. In a phase I/II open-label clinical trial OH2 was safe and efficacious as monotherapy. When combined with HX008, a humanized anti-PD-1 antibody, OH2 demonstrated a disease control rate of 50% in solid tumors (1). Here, we present the efficacy results observed in a sarcoma-specific expansion cohort of the trial. Methods: Patients refractory to ≥1 prior line of systemic therapy were allocated to a monotherapy group receiving intratumoral OH2 once every 2 weeks and a combination group receiving i.t. OH2 and HX008 (i.v) every 3 weeks. The primary endpoint was best objective response rate (ORR, per RECIST v 1.1). Secondary endpoints were disease control rate (DCR), progression free survival (PFS), overall survival (OS), duration of response (DOR) and adverse effects (AEs). Results: 26 patients were enrolled in the phase II trial, 7 in the monotherapy group and 19 in the combo group. Median age was 52 years, with 65.4% females. 50% had received ≥3 prior lines of therapy, whereas 30.7% had prior lines of immunotherapy. 25 patients were evaluable for efficacy (1 withdrew). ORR was 0% and 16.7%; DCR 14.3% and 50.0%; median PFS 1.4 and 2.1 months, and median OS 4.5 and 22.3 months, for the monotherapy and combo groups, respectively. In the combo group we observed 1 CR and 2 PRs, in which the DOR was 4.2, 5.6 and 11.1 months (Table). Angiosarcoma and fibrosarcoma patients experienced clinical benefit with durable disease control, with one angiosarcoma patient remaining in study for >1 year. Treatment was well tolerated with most common AEs being grade I and II, including GGT elevation (26.9%), fever (23.1%), neutropenia (19.2%), weight loss (15.4%), LDH elevation (15.4%), and anemia (15.4%). Conclusions: OH2 and HX008 demonstrated goodsafety and encouraging anti-tumor activity in a phase II sarcoma cohort. Further clinical investigation of this combination is warranted. 1. Zhang et al, 2021; PMID: 33837053. [Table: see text]