bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stability and Cytotoxicity Assessments of Hypericum Perforatum Nanoemulsion in Preventing Denture-related Stomatitis
Authors: Gargari Fatemeh Khaknezhad , Yasamineh Neda , Atashi Yasamin Golparvar , Dizaj Solmaz Maleki , Sharifi Simin 
Published: June 2024

Background
There is a growing interest in natural antimicrobials based on herbs, which can be used to prevent and treat oral and dental infections.

Aims
The aim of this study was to evaluate the stability and the cytotoxicity of a Hypericum perforatum nanoemulsion used to prevent denture-related stomatitis.

Methods
The ultrasonic method was used to prepare a Hypericum perforatum nanoemulsion. The prepared nanoemulsion was then characterized using conventional methods. The emulsion resistance to centrifugation was studied, and the formulation was kept at room temperature for 2 months, and any phase separation was checked. Besides, the changes in droplet diameter, polydispersity index (PDI), and surface charge were compared at different time intervals. Finally, the cytotoxicity test was conducted to determine the toxicity of the prepared nanoemulsion against human gingival fibroblasts (HGFs).

Results
The prepared nanoemulsion demonstrated proper physicochemical properties with no cytotoxicity against HGFs. The droplet size, PDI, and surface charge of the nanoemulsion showed a slight increase after 30 days (P=0.6). After 60 days, the increase in the droplet size, PDI, and surface charge were significant (P=0.03). However, the droplet size was still preserved below 200 nm, and the PDI was less than 0.7. Nanoemulsion also showed no physical changes or phase separation after centrifugation and two months of keeping at different temperatures.

Conclusion
The prepared nanoemulsion can be used to prevent and treat oral and dental infectious diseases like denture-related stomatitis.
Clinical and Bronchoscopy Assessment in Diagnosing the Histopathology Type of Primary Central Lung Tumors
Authors: Elhidsi Mia , Zaini Jamal , Rachmadi Lisnawati , Asmarinah Asmarinah , Kekalih Aria , Soeroso Noni , Rasmin Menaldi 
Published: June 2024

Background
The location and type of a tumor influence the prognosis of lung cancer. Primary Central Lung Tumors (PCLTs) are correlated with poor prognoses and certain histologic types. This study aimed to present a comprehensive exploration of clinical and bronchoscopic assessments for diagnosing the histopathology types of PCLTs and identified the factors associated with certain histologic types.

Methods
This was an observational cross-sectional study of PCLTs, defined as tumors in direct contact with hilar structures or located within the inner two-thirds of the hemithorax. We gathered demographic and clinical data, as well as data on bronchoscopy assessment and histopathology type. Tumor stage, symptoms of superior vena cava syndrome, and enlargement of lymph nodes in the paratracheal and subcarinal regions were also documented.

Results
Of the 895 patients, 37.87% had primary lung tumors, with 17.76% classified as PCLTs. Notably, PCLT cases exhibited a higher proportion of stage III (28.9% vs. 18.3%; p = 0.03) and Squamous Cell Carcinoma (SCC) histopathology (37.1% vs. 17.2%; p = 0.00) compared with non-PCLT cases. Bronchoscopic findings in PCLTs revealed a predilection for central airway masses (25.2%) and compressive distal airway stenosis (25.2%). Subgroup analysis of 159 PCLT cases identified 37.10% as SCC. Multivariate analysis underscored that intraluminal masses predict central SCC (odds ratio 2.075, 95% confidence interval 1.07–3.99; p = 0.028).

Conclusion
The proportion of stage III, SCC histopathological type, and intraluminal lesions was higher in patients with PCLT than in non-PCLT cases. The presence of intraluminal lesions can predict the histopathological type of SCC in patients with PCLTs.
Evaluation of Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography in the Western Region of Saudi Arabia
Authors: Almarzouki Nawaf K. , Kurdi Ayah M. , Aladni Ibrahim S. , Taha Mohammed A. 
Published: June 2024

Background
The Retinal Nerve Fiber Layer (RNFL) is crucial for diagnosing and monitoring optic nerve disease and physiological thinning. Optical Coherence Tomography (OCT) is an imaging technique that provides real-time scans. This procedure is used for measuring RNFL thickness and macular thickness in chorioretinal pathologies.

Objective
This study aimed to determine RNFL thickness in healthy individuals across different age groups using OCT scans.

Methods
A retrospective cross-sectional study was conducted at King Abdulaziz University Hospital in Jeddah, Saudi Arabia. The medical records of 257 patients from the clinic specialized in glaucoma were reviewed between October 2022 and October 2023. The analyzed variables included age, gender, and RNFL thickness.

Results
The study included participants aged 18 to 84 years, with an average age of 48.11 years. Females comprised the majority (59.1%) of the subjects compared to males (40.9%). The results indicated a significant association between age and RNFL thickness in various eye regions. Specifically, the superior, inferior, and temporal areas decreased in thickness with advancing age, particularly after 40. The most pronounced age-related changes were observed in the superior and inferior regions. Furthermore, females displayed a thicker RNFL in their right eye than males. The temporal and nasal regions showed a negative correlation with age, indicating a gradual but still noteworthy reduction in thickness in these areas.

Conclusion
This study aimed to establish a normative database contributing to the increase in quality of care in ophthalmology in Jeddah, Saudi Arabia, providing valuable guidance in diagnosing, managing, and researching glaucoma, ultimately improving patient outcomes in the region.
Stroke Prognostication in Patients Treated with Thrombolysis Using Random Forest
Authors: Yunus Reyhan Eddy , Harris Salim , Sidipratomo Prijo , Kekalih Aria , Jatmiko Wisnu , Pandelaki Jacub , Rachman Andhika , Syahrul   , Valindria Vanya Vabrina , Rachmadi Muhamad Febrian , Muzakki Muhammad Faris , Tjuatja Andrew , Wijaya Anthony Eka , Teresa Devina 
Published: June 2024

Background
Early identification and accurate prognostication of acute ischemic stroke are crucial due to the narrow time frame for treatment and potential complications associated with thrombolysis intervention.

Objectives
This pilot study in the Southeast Asian region using Indonesian data, aims to develop a novel machine learning model for predicting the clinical outcome of acute ischemic stroke patients following thrombolysis. The model seeks to aid clinicians in identifying eligible candidates for thrombolysis therapy.

Methods
This retrospective study at Cipto Mangunkusumo Hospital’s medical records from 2014 to 2023 used non-contrast brain CT, clinical, and lab data to develop a Random Forest (RF) algorithm predicting Δ NIHSS (National Institutes of Health Stroke Scale) score, indicating functional outcome. The developed RF model was applied to a validation dataset, with performance evaluated. The study also compared RF with a previous Convolutional Neural Networks (CNN) algorithm.

Results
This study included 145 acute ischemic stroke patients treated with thrombolysis. It demonstrated the promising feasibility of using machine learning algorithms to predict clinical outcomes in this population. Integration of CT, clinical, and laboratory data as inputs to the RF models shows the best prediction performance (Accuracy = 0.75, AUC = 0.72, F1=0.50, Precision=0.60, Sensitivity=0.43, Specificity=0.88)

Conclusions
The application of machine learning shows the potential to enhance the selection process for thrombolysis intervention in treating acute ischemic stroke. Further research with larger multicenter datasets and additional imaging modalities is required to improve predictive ability.
Can Hibiscus Sabdariffa Decrease Blood Pressure in Menopausal Women with Hypertension?
Authors: Kundarti Finta Isti , Kiswati Kiswati , Komalyna I Nengah Tanu , Riyadi Bastianus Doddy 
Published: June 2024

Background
Cases of hypertension in menopause have doubled since 1990 worldwide. During menopause, endothelial cells are destroyed due to estrogen depletion. Endothelial damage further triggers plaque in the blood while stimulating blood pressure to rise. In this case, the anthocyanin content in Hibiscus sabdariffa is an effective vasodilator of smooth muscle and blood vessels to lower blood pressure.

Purpose
This research aimed to know the effect of rosella (Hibiscus sabdariffa) on blood pressure in menopausal women with hypertension.

Methods
Quasi-experiment with pretest-posttest control group design was conducted. Ninety participants were divided into two groups, namely intervention group (45 participants) and control group (45 participants), selected from a public health center, using simple random sampling. The intervention group was given standard care and rosella extract as much as 1 x 1 with a dose of 500 mg for five days, while the control group only received standard care.

Results
Based on the paired Sample T-Test results in the experimental group, both systole and diastole pressures showed the same significant results with p-value of 0.000. Meanwhile, in the control group, the results showed a systole p-value of 0.279 and a diastole p-value of 0.132. Furthermore, the difference in posttest systole and diastole in the intervention and control groups is p-value 0.000.

Conclusion
The provision of roselle (Hibiscus sabdariffa) can reduce blood pressure in menopausal women who experience hypertension. This study is expected to help health workers provide rosella extract to menopausal women who experience hypertension as an alternative treatment.
The Clinical Severity of COVID-19 Variants of Concern: Retrospective Population-Based Analysis
Authors: Harrigan Sean P , Velásquez García Héctor A , Abdia Younathan , Wilton James , Prystajecky Natalie , Tyson John , Fjell Chris , Hoang Linda , Kwong Jeffrey C , Mishra Sharmistha , Wang Linwei , Sander Beate , Janjua Naveed Z , Sbihi Hind 
Published: June 2024

Background
SARS-CoV-2 variants of concern (VOCs) emerged and rapidly replaced the original strain worldwide. The increased transmissibility of these new variants led to increases in infections, hospitalizations, and mortality. However, there is a scarcity of retrospective investigations examining the severity of all the main VOCs in presence of key public health measures and within various social determinants of health (SDOHs).

Objective
This study aims to provide a retrospective assessment of the clinical severity of COVID-19 VOCs in the context of heterogenous SDOHs and vaccination rollout.

Methods
We used a population-based retrospective cohort design with data from the British Columbia COVID-19 Cohort, a linked provincial surveillance platform. To assess the relative severity (hospitalizations, intensive care unit [ICU] admissions, and deaths) of Gamma, Delta, and Omicron infections during 2021 relative to Alpha, we used inverse probability treatment weighted Cox proportional hazard modeling. We also conducted a subanalysis among unvaccinated individuals, as assessed severity differed across VOCs and SDOHs.

Results
We included 91,964 individuals infected with a SARS-CoV-2 VOC (Alpha: n=20,487, 22.28%; Gamma: n=15,223, 16.55%; Delta: n=49,161, 53.46%; and Omicron: n=7093, 7.71%). Delta was associated with the most severe disease in terms of hospitalization, ICU admissions, and deaths (hospitalization: adjusted hazard ratio [aHR] 2.00, 95% CI 1.92-2.08; ICU: aHR 2.05, 95% CI 1.91-2.20; death: aHR 3.70, 95% CI 3.23-4.25 relative to Alpha), followed generally by Gamma and then Omicron and Alpha. The relative severity by VOC remained similar in the unvaccinated individual subanalysis, although the proportion of individuals infected with Delta and Omicron who were hospitalized was 2 times higher in those unvaccinated than in those fully vaccinated. Regarding SDOHs, the proportion of hospitalized individuals was higher in areas with lower income across all VOCs, whereas among Alpha and Gamma infections, 2 VOCs that cocirculated, differential distributions of hospitalizations were found among racially minoritized groups.

Conclusions
Our study provides robust severity estimates for all VOCs during the COVID-19 pandemic in British Columbia, Canada. Relative to Alpha, we found Delta to be the most severe, followed by Gamma and Omicron. This study highlights the importance of targeted testing and sequencing to ensure timely detection and accurate estimation of severity in emerging variants. It further sheds light on the importance of vaccination coverage and SDOHs in the context of pandemic preparedness to support the prioritization of allocation for resource-constrained or minoritized groups.
Virtual Clinic Telehealth Abortion Services in the United States One Year After Dobbs: Landscape Review
Authors: Koenig Leah R , Ko Jennifer , Upadhyay Ushma D 
Published: June 2024

Background
Telehealth abortion has taken on a vital role in maintaining abortion access since the Dobbs v. Jackson Women’s Health Organization Supreme Court decision. However, little remains known about the landscape of new telehealth-only virtual clinic abortion providers that have expanded since telehealth abortion first became widely available in the United States in 2021.

Objective
This study aimed to (1) document the landscape of telehealth-only virtual clinic abortion care in the United States, (2) describe changes in the presence of virtual clinic abortion services between September 2022, following the Dobbs decision, and June 2023, and (3) identify structural factors that may perpetuate inequities in access to virtual clinic abortion care.

Methods
We conducted a repeated cross-sectional study by reviewing web search results and abortion directories to identify virtual abortion clinics in September 2022 and June 2023 and described changes in the presence of virtual clinics between these 2 periods. In June 2023, we also described each virtual clinic’s policies, including states served, costs, patient age limits, insurance acceptance, financial assistance available, and gestational limits.

Results
We documented 11 virtual clinics providing telehealth abortion care in 26 states and Washington DC in September 2022. By June 2023, 20 virtual clinics were providing services in 27 states and Washington DC. Most (n=16) offered care to minors, 8 provided care until 10 weeks of pregnancy, and median costs were US $259. In addition, 2 accepted private insurance and 1 accepted Medicaid, within a limited number of states. Most (n=16) had some form of financial assistance available.

Conclusions
Virtual clinic abortion providers have proliferated since the Dobbs decision. We documented inequities in the availability of telehealth abortion care from virtual clinics, including age restrictions that exclude minors, gestational limits for care, and limited insurance and Medicaid acceptance. Notably, virtual clinic abortion care was not permitted in 11 states where in-person abortion is available.
REMOVAL OF COD, BOD, AMMONIA AND TSS USING ELECTROCOAGULATION METHOD WITH A COMBINATION OF ALUMINUM (Al) AND IRON (Fe) ELECTRODES IN FISH PROCESSING WASTEWATER
Authors: Munawarah Syahna , Juliansyah Harahap  , Rohendi Aulia 
Published: June 2024

The Wastewater from fish processing contains highly organic pollutants, causing pollution to water bodies. Electrocoagulation method is utilised in fisheries wastewater treatment because of its simple and easier to do and also effective in removing pollutants. This research uses an experimental method with a quantitative approach by using dependent variables such as COD, BOD, ammonia, TSS and pH and independent variables such as electrical voltage of 3, 5 volts and contact time of 60, 90 and 120 minutes. The results of the electrocoagulation process using Al and Fe electrodes showed the effectiveness of reducing the concentration of COD, BOD and TSS values ​​by 96.34%, 95.2% and 73.22% with the maximum voltage of 5 volts and a contact time of 120 minutes. The effectiveness of reducing ammonia concentration occured at the optimum voltage of 3 with a contact time of 60 minutes, which was 98.75%. The pH concentration increased from acidic to alkaline. Based on the results of this study, the amount of voltage in the electrocoagulation method can affect the concentration of COD, BOD, ammonia and TSS contained in wastewater from fish processing. The results obtained show the quality of wastewater in accordance with predetermined quality standards.
Multiple effects of L-leucine in Escherichia coli lead to L-leucine sensitive growth in the absence of dephospho-PtsN
Authors: Kumar Neeraj , Sardesai Abhijit 
Published: June 2024

In E. coli K-12, absence of dephospho-PtsN, is thought to cause
an L-leucine sensitive growth phenotype (Leu) by
hyperactivated K uptake mediated impairment of the
expression of the ilvBN operon, encoding subunits of the L-valine
(Val) sensitive acetohyrodxyacid synthase I (AHAS I), that renders
residual AHAS activity susceptible to inhibition by Leu and
K. This is thought to lead to AHAS insufficiency and
a requirement for isoleucine (Ile). Herein we provide an alternate
mechanism for Leu of the ∆ptsN mutant. Genetic
and physiological studies with suppressors of the
Leu, indicate that impaired expression of the
ilvBN operon jointly caused by the absence of dephospho-PtsN and
the presence of Leu coupled to Leu mediated repression of expression of
AHAS III leads to AHAS insufficiency rendering residual AHAS activity
susceptible to chronic Val stress that may be generated by exogenous
Leu. Hyperactivated K uptake and an elevated
α-ketobutyrate level, mediate elevation of ilvBN expression, and
alleviate the Leu. The requirement of dephospho-PtsN
as a positive regulator of ilvBN expression, may buffer Ile
biosynthesis against Leu mediated AHAS insufficiency and protect AHAS I
function from chronic endogenous Val generated by Leu and could be
realised in certain environments that impair AHAS function.
Global analysis of surface ocean CO2 fugacity and air-sea fluxes with low latency
Authors: Chau Thi-Tuyet-Trang , Chevallier Frederic , Gehlen Marion 
Published: June 2024

The Surface Ocean CO2 Atlas (SOCAT) of CO2 fugacity (fCO2) observations
is a key resource supporting annual assessments of CO2 uptake by the
ocean and its side effects on the marine ecosystem. SOCAT data are
usually released with a lag of up to 1.5 years which hampers timely
quantification of recent variations of carbon fluxes between the Earth
System components, not only with the ocean. This study uses a
statistical ensemble approach to analyse fCO2 with a latency of one
month only based on the previous SOCAT release and a series of
predictors. A retrospective prediction for the years 2021-2022 is made
to test the model skill, followed by the generation of fCO2 and fluxes
from January to August in 2023. Results indicate a modest degradation of
the model skill in prediction mode and open the possibility to provide
robust information about marine carbonate system variables with low
latency.
Attached is the original manuscript version, please direct to the
published version via the link below.

How to cite

Chau, T.-T.-T., Chevallier, F., & Gehlen, M. (2024). Global analysis of
surface ocean CO fugacity and air-sea fluxes with low
latency. Geophysical Research Letters, 51, e2023GL106670.
https://doi.org/10.1029/2023GL106670
Analisis Kekerasan Verbal Orang Tua dan Pengaruhnya terhadap Kepercayaan Diri Remaja
Authors: Rahmah Siti , Elmanora Elmanora , Hasanah Uswatun 
Published: June 2024

Masa remaja merupakan peralihan masa pertumbuhan dan perkembangan individu dari masa kanak-kanak ke masa dewasa yang dapat ditandai dengan perubahan biologis, perubahan psikologis, maupun perubahan sosial. Jika remaja memiliki kepercayaan diri yang rendah maka hal tersebut dapat menghambat perkembangan remaja dalam bersosialisasi dengan lingkungannya, sulit mengembangkan potensi yang dimiliki, kesulitan mengenal dirinya dan tugas perkembangan lainnya. Penelitian ini memiliki bertujuan untuk menganalisis pengaruh kekerasan verbal orang tua terhadap kepercayaan diri remaja. Penelitian ini menggunakan metode penelitian kuantitatif. Penelitian ini melibatkan 241 orang siswa SMP yang dipilih dengan metode purposive sampling dengan karakteristik memiliki kedua orang tua. Pengumpulan data menggunakan instrumen Kekeraran Verbal Orang Tua dan Personal Evaluation Inventory (PEI). Data tersebut diolah dengan menggunakan uji regresi linear sederhana. Hasil penelitian menunjukkan bahwa kekerasan verbal orang tua berpengaruh negatif terhadap kepercayaan diri remaja, yang mengartikan bahwa semakin tinggi kekerasan verbal orang tua maka kepercayaan diri yang dimiliki remaja semakin rendah. Untuk meningkatkan kepercayaan diri, orang tua diharapkan untuk menghindari ucapan yang menyakiti hati anak.
Hedonic Shopping Motives of Shopee Generation Z Concumers towards Impulse Purchases of Skincare Products
Authors: Elgeka Honey Wahyuni Sugiharto , Tania Adeilla 
Published: June 2024

Saat ini generasi Z memiliki ketertarikan yang besar terhadap dunia kecantikan. Maraknya tren skincare disertai dengan marketplace yang berkembang ternyata mempengaruhi perilaku konsumen. Penelitian ini memiliki tujuan untuk menguji hubungan antara hedonic shopping motives dengan impulsive buying pada konsumen Shopee generasi Z saat membeli produk skincare. Penelitian ini merupakan penelitian kuantitatif yang menggunakan metode pengambilan data melalui kuesioner. Teknik pengambilan sampel yang digunakan pada penelitian ini adalah accidental sampling. Subjek penelitian ini adalah konsumen Shopee, berjenis kelamin laki-laki atau perempuan, memiliki tahun kelahiran 1997-2003, dan pernah membeli skincare minimal 2 kali dalam sebulan di Shopee, sejumlah 295 responden. Alat ukur yang digunakan pada penelitian ini adalah Buying Impulsiveness Scale dan Hedonic Shopping Motivation Scale. Hasil penelitian menunjukkan hedonic shopping berhubungan positif signifikan dengan impulsive buying. Artinya semakin tinggi hedonic shopping motives maka semakin tinggi kecenderungan seseorang untuk impulsive buying motives. Adventure shopping, gratification shopping, role shopping, value shopping, social shopping, dan idea shopping berhubungan positif signifikan dengan impulsive buying. Hasil penelitian ini disarankan untuk konsumen Shopee generasi Z agar lebih berhati-hati terhadap motif-motif hedonic shopping yang bisa meningkatkan kecenderungan untuk impulsive buying.
Failure Risk Analysis in the Plastic Yarn Production Process Using the FMEA Method and Kaizen Approach
Authors: Dewantara Ananda Bayu , Dahda Said Salim , Dahda Said Salim 
Published: June 2024

The manufacturing industry is a key pillar in global economic growth, yet the risk of failure remains a crucial challenge. PT XYZ, a plastic yarn manufacturer in Gresik, faces similar challenges despite achieving success. The production process is not yet optimal, with a defect rate exceeding the standard limit. This research utilizes the FMEA and Kaizen approaches to identify priority failure modes and propose improvements. Analysis indicates that yarn spot defects are the top priority for correction, attributed to insufficient pump pressure. Proposed improvements based on the Risk Priority Number include installing pressure control devices, implementing preventive maintenance, and providing support facilities for operators. Therefore, these improvements are expected to enhance the efficiency and the quality of the plastic yarn production process at PT XYZ Gresik. Keywords: Diagram Pareto, Diagram Fish Bone, FMEA, Kaizen