bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Pre-treatment of Withania somnifera Root Extract and Cow Urine on Hemato-biochemical Parameters in Acetaminophen-induced Toxicity in Swiss Albino Male Mice
Authors: . Preetam , Tiwari V. , Jangir B.L. 
Published: May 2024

Background: The present study was undertaken to investigate protective activity of W. somnifera root extract (W.S.R.E.), cow urine (C.U.) and their combination against acetaminophen (APAP) induced toxicity in male mice. APAP also known as paracetamol, is a well-known drug used for its analgesic and antipyretic effects. However, outside of the therapeutic window, the toxicity may result. W.S. and C.U. are from indigenous sources of plant and animal origins, respectively with several therapeutic activities. Methods: Sixty adult swiss albino male mice were randomly divided into six groups, comprising of ten mice in each group. Group I (control group) received 2% gum acacia suspension for 14 days orally and on day 14, 0.9% NaCl (@300 mg/kg b.wt.) intraperitoneally was administered after 30 min of prior treatment of various agents. Group II, III, IV, V and VI received 2% gum acacia, silymarin (@25 mg/kg b.wt.), W.S.R.E. (@100 mg/kg b.wt.), C.U. (@7.8 mL/kg b.wt.) and W.S.R.E. (@100 mg/kg b.wt.) and C.U. (@7.8 mL/kg b.wt.) co-treatment orally for 14 days and on day 14, APAP (@300 mg/kg b.wt.) intraperitoneally was administered after 30 min of prior treatment of various agents as mentioned. On 15th day, the animals were sacrificed and samples were collected to study various hematobiochemical and growth related parameters. Result: The treatment of acetaminophen caused significant decrease in haemoglobin, total erythrocyte count whereas increase in total leucocyte and prothrombine time. There were significant (p£0.05) decreases in plasma total protein, albumin and globulin values in group II (APAP), as compared to control (group I). Treatment with W.S. +C.U attenuates these alterations. W.S.R.E., C.U. and their combination pre-treatment mildly restored the changes to normal observed following APAP exposure in mice. However, the results of co-treatment group were more pronounced as compared to individual treatment groups. Thus, it was concluded that treatment with W.S.R.E. and C.U. curtailed the toxic effect of APAP, however, co-administration of both potentiated the protective effect.
Metodologia ativas e agente comunitário de saúde
Authors: Carvalho Ana Mariza de , Lima Sabrina de Sousa , Santos Etelvina Gonçalves dos , Araújo Moziane Mendonça de , Silva André Luis Façanha da 
Published: May 2024

Objetivo: Descrever as vivência e atividades desenvolvidas com uso de metodologias ativas pelo Grupo de Trabalho PET Saúde Mental com os/as Agentes Comunitários de Saúde (ACS’s) em uma Unidade Básica de Saúde (UBS) de um município da região Centro-Sul do Ceará. Metodologia: Trata-se de um estudo descritivo, com abordagem qualitativa e do tipo relato de experiência. Foi utilizado o diário de campo elaborado pelos estudantes, docentes e profissionais de graduação em Enfermagem e Educação Física, integrantes do Programa de Educação Pelo Trabalho para a Saúde (PET-Saúde). O cenário da experiência foi em um território da Atenção Básica à Saúde (ABS) da cidade de Iguatu-CE, no período de sete meses. Resultados e discussão: foi aplicado o círculo de cultura que emergiram palavras geradoras que foram desenvolvidas com uso de metodologias ativas. A colaboração de uma enfermeira coordenadora de uma Equipe de Saúde da Família e a implicação de alguns ACS’s foram aspectos facilitadores. Entretanto, pontos dificultadores foram a estrutura física limitada da UBS, que pode ter influenciado na oscilação na adesão dos/as ACS’s no transcorrer dos encontros. Contudo, os aprendizados dos integrantes do programa, é possível mencionar o desenvolvimento de habilidades para o trabalho em equipe de forma multi e interdisciplinar. Considerações Finais: conclui-se que, implantar espaços democráticos que tematizem a saúde mental dos/as trabalhadores/as da ABS podem contribuir com a redução de danos provocadas pela extensa e intensa rotina de trabalho dos/as ACS’s.
Audiolivros na Ciência da Informação
Authors: Gonçalves Suellen Souza , Nascimento Silva Patrícia 
Published: May 2024

Introdução: O audiolivro é uma gravação sonora de um livro ou qualquer texto, em que pode escutar, em vez de ler. Este suporte pode conter efeitos sonoros, como música ou sons ambientes, narração ou voz sintética. Com as inovações tecnológicas e novos suportes, o audiolivro evoluiu e atualmente é comercializado em formatos digitais. No contexto da Ciência da Informação (CI), entender como os audiolivros estão organizados e representados é fundamental para sistematizar sua recuperação. Objetivo: Delinear um panorama da temática dos audiolivros na área da CI, com foco em sua representação e recuperação. Metodologia: o estudo caracterizado como descritivo e exploratório, com abordagem qualitativa e quantitativa, realizou uma Revisão Sistemática de Literatura (RSL), para investigar a produção acadêmica sobre a temática, sem delimitação de tempo, executada em 2023. Resultados: A RSL incluiu três etapas de análise, alcançando uma amostra de 24 documentos. Foi possível identificar que os audiolivros estão inseridos em diversas áreas do conhecimento e são utilizados de diversas formas, abrangendo aprendizagem, inclusão e acesso à informação em bibliotecas e centros de informação, onde sua aquisição ainda é discutida, principalmente com relação aos custos. Há iniciativas para representação textual, no contexto da CI, no entanto, sem um olhar específico para os formatos e ambientes onde os audiolivros estão disponibilizados. Conclusão: A quantidade limitada de estudos que abordaram a representação e a recuperação da informação em audiolivros na CI pode sinalizar que a temática precisa ser aprofundada, principalmente com o avanço dos serviços streaming e plataformas digitais.
Interrelacionamento entre governança, gestão estratégica, administração e planejamento estratégico em instituições de ensino superior
Authors: Atvars Teresa Dib Zambon , Serafim Milena Pavan , Silva Ana Maria Alves Carneiro da 
Published: May 2024

Objetivos: Esse artigo procura analisar as relações entre governança e planejamento em uma instituição de ensino superior pública, buscando correlacionar esses processos com a efetiva implantação de ações e projetos estratégicos. Metodologia: Essa análise contempla um estudo de caso, o da Universidade Estadual de Campinas (UNICAMP), com resultados de dois ciclos de planejamento estratégico, alinhando-se às tendências internacionais de utilizar planejamento estratégico para orientar parte das ações institucionais. Para o desenvolvimento do trabalho foram utilizadas referências bibliográficas relacionadas aos temas Planejamento estratégico. Governança universitária. Gestão Estratégica, bem como documentos e relatórios descritivos do caso. Resultados: Esse trabalho relata alguns dos avanços institucionais diretamente vinculados aos dois ciclos de planejamentos, procurando identificar alguns padrões de governança e de estrutura organizacional essenciais para viabilizar a execução do planejamento. Dentre eles, a gestão estratégica é um dos fatores mais importantes; sem o comprometimento das lideranças e sem o acompanhamento e a divulgação das ações, o planejamento não produz resultados. Conclusões: O trabalho mostrou que são necessárias uma estrutura e uma governança institucional adequadas à gestão estratégica; que a cultura de planejamento está disseminada na instituição, porém nem todos os órgãos desenvolvem projetos de transformação organizacional que geram uma instituição mais eficiente. Portanto, permanecem desafios de governança, tais como a dissonância entre a gestão estratégica que viabiliza os objetivos estratégicos e o plano da administração das lideranças; a ampla divulgação dos objetivos estratégicos e de seus resultados ainda é pouco abrangente; e há dificuldades de coordenação para envolver toda a comunidade nessa forma de administração.
Validation of single nucleotide polymorphisms potentially related to R-CHOP resistance in diffuse large B-cell lymphoma patients
Authors: Perrone Gabriele , Rigacci Luigi , Roviello Giandomenico , Landini Ida , Fabbri Alberto , Iovino Lorenzo , Puccini Benedetta , Cencini Emanuele , Orciuolo Enrico , Bocchia Monica , Bosi Alberto , Mini Enrico , Nobili Stefania 
Published: May 2024

Aim: Diffuse large B-cell lymphoma (DLBCL) is the most common B-cell non-Hodgkin lymphoma (NHL). Despite the availability of clinical and molecular algorithms applied for the prediction of prognosis, in up to 30%-40% of patients, intrinsic or acquired drug resistance occurs. Constitutional genetics may help to predict R-CHOP resistance. This study aimed to validate previously identified single nucleotide polymorphisms (SNPs) in the literature as potential predictors of R-CHOP resistance in DLBCL patients, SNPs.
Methods: Twenty SNPs, involved in R-CHOP pharmacokinetics/pharmacodynamics or other pathobiological processes, were investigated in 185 stage I-IV DLBCL patients included in a multi-institution pharmacogenetic study to validate their previously identified correlations with resistance to R-CHOP.
Results: Correlations between rs2010963 (VEGFA gene) and sex (P = 0.046), and rs1625895 (TP53 gene) and stage (P = 0.003) were shown. After multivariate analyses, a concordant effect (i.e., increased risk of disease progression and death) was observed for rs1883112 (NCF4 gene) and rs1800871 (IL10 gene). When patients were grouped according to the revised International Prognostic Index (R-IPI), both these SNPs further discriminated progression-free survival (PFS) and overall survival (OS) of the R-IPI-1-2 subgroup. Overall, patients harboring the rare allele showed shorter PFS and OS compared with wild-type patients.
Conclusions: Two out of the 20 study SNPs were validated. Thus, these results support the role of previously identified rs1883112 and rs1800871 in predicting DLBCL resistance to R-CHOP and highlight their ability to further discriminate the prognosis of R-IPI-1-2 patients. These data point to the need to also focus on host genetics for a more comprehensive assessment of DLBCL patient outcomes in future prospective trials.
Pengembangan Media Video Tutorial Loving-Kindness Meditation untuk Meningkatkan Regulasi Emosi Mahasiswa Universitas Negeri Jakarta
Authors: Gita Suci Anjelita  , Wahyuni Eka 
Published: May 2024

Penelitian ini bertujuan untuk mengembangkan media video tutorial loving-kindness meditation untuk meningkatkan kemampuan regulasi emosi mahasiswa, khususnya mahasiswa Universitas Negeri Jakarta. Video tutorial loving-kindness meditation digunakan sebagai media informasi mengenai regulasi emosi dan loving-kindness meditation, serta sebagai alat bantu mandiri bagi mahasiswa yang mengalami kesulitan regulasi emosi di usia emerging adulthood pada kondisi pandemi covid-19. Responden penelitian ini berjumah 272 mahasiswa Universitas Negeri Jakarta dari 8 fakultas yaitu, FIP, FBS, FMIPA, FIS, FT, FIO, FE, dan FPPsi. Hasil penelitian menggunakan instrumen DERS-SF (Difficulties in Emotion Regulation Scale – Short Form) menunjukkan rata-rata skor kesulitan regulasi emosi mahasiswa berada di angka 53 yang berarti berada pada kategori sedang. Metode yang digunakan untuk pengembangan media yaitu, DBR (Design Based Research) dengan tiga tahapan yaitu, analisis dan eksplorasi, desain dan konstruksi, serta evaluasi dan refleksi. Namun, penelitian ini hanya dibatasi sampai tahap evaluasi. Video tutorial loving-kindness meditation telah di uji oleh ahli media dan materi dengan persentase 98% untuk media dan 93% untuk materi. Hal ini menunjukkan bahwa media yang telah dikembangkan dikategorikan sangat layak untuk digunakan.
Pengembangan Media Workbook dengan Mindful Self-Compassion untuk Meningkatkan Regulasi Emosi Mahasiswa Universitas Negeri Jakarta
Authors: Yulianti Indah Dwi , Eka Wahyuni  
Published: May 2024

Penelitian ini bertujuan untuk mengembangkan media workbook dengan mindful self-compassion untuk meningkatkan regulasi emosi mahasiswa Universitas Negeri Jakarta (UNJ). Penelitian ini menggunakan metode Design Based Research (McKenney & Reeves, 2018) yang terdiri dari tiga tahapan, yaitu: analisi – eksplorasi, desain – konstruksi, dan evaluasi – refleksi. Pada tahap analisis peneliti melakukan studi pendahuluan pada 272 mahasiswa UNJ dengan hasil skor rata-rata kesulitan regulasi emosi (Goals, Strategy, Clarity, impulse, non-acceptance, Awareness) mahasiswa sebesar 53 dan 91% mahasiswa menyatakan tertarik dalam pembuat media workbook untuk latihan Mindful self-compassion. Mahasiswa berasal dari Fakultas Ilmu Pendidikan, Fakultas Bahasa dan Seni, Fakultas Ilmu Sosial, Fakultas Teknik, Fakultas Ilmu Olahraga, Fakultas Psikologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, dan Fakultas Ekonomi. Evaluasi dilakukan oleh validator ahli media dan ahli materi dengan hasil validasi ahli media sebesar 57% (layak) dan validasi ahli materi 75% (layak). Hasil dari penelitian ini adalah workbook dengan mindful self-compassion untuk meningkatkan regulasi emosi mahasiswa UNJ. Peneliti selanjutnya dapat melakukan uji pilot untuk keefektifan workbook MSC.
Pengaruh Expressive Writing Therapy Terhadap Stres Akademik Yang Timbul Pada Siswa SMA Swasta di Jakarta
Authors: Maulida Siti Aisyah , Fitriyani Hilma 
Published: May 2024

Tujuan penelitian ini adalah untuk mengetahui pengaruh expressive writing therapy pada stres akademik yang dialami oleh siswa SMA Suluh Jakarta. Metode penelitian menggunakan experimental design dengan jenis the pretest-posttest control group design. Penelitian menggunakan kelompok eksperimen dan kelompok kontrol. Subjek penelitian berjumlah 18 siswa dengan pembagian 10 siswa ada pada kelompok eksperimen dan 8 siswa ada di kelompok kontrol. Pengambilan data menggunakan ESSA (Educational Stress Scale of Adolescent). Sebanyak 16 butir pernyataan dengan hasil uji validitas yang dilakukan kepada 122 siswa menunjukan semua butir pernyataan valid dengan rentang koefiensi validitas sebesar 0,313-0,702. Uji reabilitas semua butir pernyataan menunjukan hasil 0,846 dengan nilai koefisiensi alpha Cronbach berada pada kategori sangat tinggi. Hasil pengujian hipotesisi menunjukan p = 0.005 < 0.05 (Nilai Signifikan), diinterpretasikan bahwa terdapat perbedaan siginifikan antara kelompok eksperimen dan kelompok kontrol. Dengan demikian terdapat penurunan stres akademik siswa yang mendapatkan treatment expressive writing therapy lebih besar dibandikan rata-rata stres akademik siswa yang tidak diberikan perlakuan.
WITHDRAWN: The association between short-term exposure to PM1 and daily hospital admission and related expenditures in Beijing
Authors: Xu Jingwen , Chen Yan , Fan Wenhong , Lu Feng , Dong Zhaomin 
Published: May 2024

Abstract

The full text of this preprint has been withdrawn by the authors while they make corrections to the work. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Specialized Open-Transmit and flexible receiver Head Coil for High Resolution Ultra-high field fMRI of the Human Somatosensory and Motor Cortex
Authors: Li Ye , Wei Zidong Zidong , Zhang Zhilin , Chen Qiaoyan , Wang Cuiting , Fu Shuyue , Wang Haifeng , Zhang Xiaoliang , Liu Xin , Zheng Hairong , Wu Jinglong 
Published: May 2024

Abstract

This study presents an open-transmit and 24-channel flexible receiver head coil assembly tailored for high-resolution ultra-high field fMRI of the human somatosensory and motor cortex. Leveraging the increased signal-to-noise ratio (SNR) and spatial resolution of ultra-high field MRI, we address the technical challenges inherent in fMRI coil design. The open birdcage transmit coil enhances patient comfort and enables visual task implementation, demonstrating superior performance in transmit efficiency and SAR distribution compared to conventional coils. Furthermore, the 24-channel flexible receiver head coil offers enhanced SNR and image quality, facilitating sub-millimeter VASO imaging for precise functional mapping. These advancements provide valuable tools for unraveling the intricacies of somatosensory and motor cortex function. By enriching human brain functional studies, they contribute significantly to our understanding of the mechanisms underlying somatosensory and motor cortex function, with potential implications for clinical applications in neurology and neuroscience research.
Study of the Anatomical Growth Parameters of lentil Plant to Pre-soaked Seed treatment with Water Extract of Wolffia arrhiza
Authors: Tiwari Amit 
Published: May 2024

Abstract

Wolffia arrhiza is known as noxious weed and rated as one of the ten weeds growing country in South – East Asia, Commonly infesting natural impounded water in India. Studies have been made for their utilization in multiple ways in developing countries. Present study based on 24 hours pre-soaking seed treatment with control, 1,2 and 5% concentration of water extract of W. arrhiza for anatomical growth of stem of lentil plants variety DPL-15. The observation of stem show that the anatomical growth parameters like average diameter of stem, average thickness of stele, number of vascular bundles per microscopic field, average diameter of Xylem vessels, average diameter of Phloem is stimulated in seed treated with water extract for 24 hours. 5% level of water extract of W. arrhiza was found best for diameter of stem, number of vascular bundles per-microscopic field, and average thickness of stele. However for average diameter of Xylem vessels and average diameter of Phloem of lentil stem was observed better at 2% level of water extract of W. arrhiza. Results are statistically analyzed at 5% error probability.
Effect of surface crosslinking on the Friction behavior of Tea Polyphenol stabilized Ultra-high molecular weight polyethylene
Authors: Ahmad Adnan , Shah Nouman Ali , Gul Rizwan M. , Kamran M. Ali , Ishaq M. Aaqib , Xu Jia Zhuang , Li Zhong Ming , Sagbas Binnur 
Published: May 2024

Abstract

The use of highly crosslinked ultra-high molecular weight polyethylene (UHMWPE) incorporating vitamin E (VE) as an antioxidant is widely acknowledged in the field of joint implants. While VE plays a crucial role in preventing oxidation, concerns have been raised regarding its impact on crosslink density, leading to wear performance deterioration. This study proposes the hypothesis that tea polyphenols, specifically lipid-soluble epigallocatechin gallate (IsEGCG) and epigallocatechin gallate (EGCG), may counteract the typical decrease in crosslink density caused by VE, thereby enhancing wear performance. The antioxidants were integrated into UHMWPE at a concentration of 0.2 wt%, followed by surface chemical crosslinking using di-cumyl peroxide. Surface properties, including crosslink density, roughness, coefficient of friction, and wear performance, were comprehensively evaluated. The results indicate a significantly higher crosslink density in UHMWPE blended with IsEGCG and EGCG compared to VE-stabilized UHMWPE, which exhibited a 17% reduction compared to virgin UHMWPE. The coefficient of friction increased post-crosslinking, with tea polyphenol-blended UHMWPE demonstrating a relatively higher value, confirming a highly crosslinked network structure. The wear resistance of surface-crosslinked UHMWPE stabilized with tea polyphenols was markedly superior compared to UHMWPE stabilized with VE. Additionally, a substantial presence of scratches, furrows, and flakes was observed on the surface of VE-stabilized UHMWPE in contrast to tea polyphenol-stabilized UHMWPE. These findings suggest that tea polyphenols present promising alternatives to VE for enhancing the overall performance and longevity of UHMWPE-based implants.
Swarm-optimized numerical investigation of Dengue Fever Model
Authors: Riaz Farhad Muhammad , Ullah Raja Muhammad Shamayel , Alasiry Areej , Marzougui Mehrez , Khan Junaid Ali 
Published: May 2024

Abstract

The current study aims to present a swarm-optimized technique for the numerical treatment of dengue fever non-linear model. The model is composed of the coupled nonlinear system comprising the susceptible, infected, and recovered compartments. The system is transformed into an unsupervised single layer feed-forward artificial neural network with a Mexican hat wavelet activation function in the hidden layer. The unknowns of the neural network is optimized with particle swarm optimization as an efficient global search aided by the effective local search technique based on sequential quadratic programming. The presented results are compared with state of art Runge-Kutta method and other modern reported techniques on various performance indicators like absolute error, mean average deviation, global absolute error, global mean average deviation, convergence, and computational complexity. Comprehensive Monte Carlo simulations and their statistical analysis are presented to ensure accuracy, consistency in convergence, and computational complexity in terms of execution time. It is observed that the proposed scheme is accurate, reliable, convergent, and computationally viable in treating the nonlinear coupled system under consideration.
Analysis Sensitivity Digital Twin Model of Energy Community PV system
Authors: Rubanenko Olena , Belik MILAN 
Published: May 2024

Abstract

In the paper presented current energy situation in Ukraine after last attacks, issues and ways of decisions are analyzed. One of the approaches of increasing energy safety in Ukraine is decentralization of energy sources. Digitization, Decarbonization, Decentralization energy sector are main goals of rebuild plan Ukraine, and response goal of sustainable development EU. Main benefits of decentralization of energy sources are highlighted. Creation of energy community with distributed renewable energy sources is way of adopt to current situation in deficit centralized power supply. Digitization energy community realized through Digital Twin. Digital Twin concept helps design and control, modify during usage and develop recommendations for operation PV system. For optimization process of development energy community need take into account technical, meteorological, social, financial and ecology factors. For solving complex optimization task proposed use criterion programming method. Theory sensitivity is applied for optimization control task energy community. Model shelter-city energy community was developed and described.