bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A New Versatile Route for the Conversion of Phospholes into Phosphinines.
Authors: Wang Huaiqiu , Li Chuan , Geng Dingjin , Chen Hui , Duan Zheng , Mathey Francois 
Published: December 2010

AbstractA novel four‐step route towards phosphinines involves the cycloaddition of corresponding phospholes with diverse alkynes, followed by oxidation and oxygen—sulfur exchange at the phosphorus.
ChemInform Abstract: Silyl‐ and Germylpropynals in the Synthesis of Azolyl‐Substituted 2‐Imidazoline 3‐Oxide 1‐Oxyls.
Authors: Tretyakov E. V. , Mareev A. V. , Demina M. M. , Romanenko G. V. , Stass D. V. , Medvedeva A. S. , Ovcharenko V. I. 
Published: December 2010

AbstractThe synthesis, structures, and magnetic properties of azolyl‐substituted nitronylnitroxyls containing bulky SiMe3 or GeEt3 groups are reported.
ChemInform Abstract: Facile Access to Optically Active Ring C Aromatic Diterpenes from (+)‐Manool (I). Synthesis of (+)‐13‐Hydroxypodocarpa‐8,11,13‐triene (IVa), (+)‐7‐Deoxynimbidiol (IVb) and (+)‐Nimbidiol (V)
Authors: Villamizar Jose E. , Montiel Crisbel , Gamez Carlos , Alcala Antonio , Herrera Yurimar , Salazar Franklin , Tropper Eleonora , Canudas Nieves 
Published: December 2010

Abstractvia β‐enone (III) as key intermediate
ChemInform Abstract: Unusual Antimalarial Meroditerpenes from Tropical Red Macroalgae
Authors: Stout E. Paige , Prudhomme Jacques , Le Roch Karine , Fairchild Craig R. , Franzblau Scott G. , Aalbersberg William , Hay Mark E. , Kubanek Julia 
Published: December 2010

Abstractisolation and structure determination of three antimalarial meroditerpenes including the new compound callophycolide A (I)
ChemInform Abstract: Bufogargarizins A (I) and B (II): Two Novel 19‐Norbufadienolides with Unprecedented Skeletons from the Venom of Bufo bufo gargarizans
Authors: Tian Hai‐Yan , Wang Lei , Zhang Xiao‐Qi , Wang Ying , Zhang Dong‐Mei , Jiang Ren‐Wang , Liu Zhong , Liu Jun‐Shan , Li Yao‐Lan , Ye Wen‐Cai 
Published: December 2010

Abstractisolation and structure elucidation
ChemInform Abstract: Improved Synthesis of L,L‐Cycloisodityrosine Subunit of Antitumor Agents Deoxybouvardin and RA‐VII.
Authors: Ghosh Samir , Kumar Sanjeev , Mehta G. N. , Soundararajan R. 
Published: December 2010

AbstractA facile synthesis of the core cycloisodityrosine 14‐membered ring system of the title antitumor agent is described involving intramolecular cyclization of boronic aicd (I) as the key step.
ChemInform Abstract: Novofumigatamide (I), New Cyclic Tripeptide from Aspergillus novofumigatus
Authors: Ishikawa Kazuki , Hosoe Tomoo , Itabashi Takeshi , Takizawa Kayoko , Yaguchi Takashi , Kawai Ken‐ichi 
Published: December 2010

Abstractisolation, structure, antifungal and cytotoxic activities
ChemInform Abstract: Enantioselective Synthesis of the Diazatricyclic Core of Alkaloid TAN1251C via an Iodoaminocyclization Reaction.
Authors: Zhang Hongkui , Lin Zhijie , Huang Huang , Huo Haohua , Huang Yanju , Ye Jianliang , Huang Peiqiang 
Published: December 2010

AbstractThe concise protocol features the stereoselective formation of the azaspirodecane cores (III) from homoallylic amines (I) by iodine‐promoted iodoaminocyclization, a previously claimed to be unsuccessful reaction.
ChemInform Abstract: Two New Steroidal Alkaloids from Veratrum nigrum var. ussuriense
Authors: Zhou Xue Feng , Gao Zhi Gang , Han Xu Ran , Zhao Wei Jie , Wang Shi Sheng 
Published: December 2010

Abstractisolation and structural elucidation of steroidal alkaloids veraussine A (Ia) and veraussine B (Ib)
ChemInform Abstract: Synthesis and anti‐HIV Evaluation of New Acyclic Phosphonate Nucleotide Analogues and Their Bis(sate) Derivatives.
Authors: Li Hua , Hong Joon Hee 
Published: December 2010

AbstractCyclopentene phosphonate nucleoside prodrugs (VI) and (VII) exhibit increased anti‐HIV activity compared to the parent phosphonic acids and are relatively stable in neutral and weakly acidic media.
ChemInform Abstract: Investigation on Coordination Number and Geometrical Conformation of Rare Earth Complexes with Catenulate Aminopolycarboxylic Acid Ligands
Authors: Wang Jun , Hu Ping , Liu Bin , Jin Xudong , Kong Yumei , Gao Jingqun , Wang Dan , Wang Baoxin , Xu Rui , Zhang Xiangdong 
Published: December 2010

AbstractReview: 110 refs.
ChemInform Abstract: “Alive” Dyes as Fluorescent Sensors: Fluorophore, Mechanism, Receptor and Images in Living Cells
Authors: Qian Xuhong , Xiao Yi , Xu Yufang , Guo Xiangfeng , Qian Junhong , Zhu Weipin 
Published: December 2010

AbstractReview: [94 refs.]
New Material Design Strategy for Chromatographic Separation Steps in Bio‐Recovery and Downstream Processing
Authors: Ndocko Ndocko Eugene , Ditz Reinhard , Josch Jan‐Pablo , Strube Jochen 
Published: December 2010

AbstractThe increasing demand for higher efficiency, better economy, and more sustainability in bioprocess design has led to approaches characterized by high‐throughput screening and the implementation of platform technologies. The presented approach incorporates an a priori material design strategy for selective materials in combination with process development and design to address the full optimization potential of all elements involved. The design strategies are directly linked with an economic process assessment to provide quantitative data for the implementation. Different material design parameters like pore structure were varied in the presented theoretical study. A rigorous material design model is proposed for so‐called irregularities within the porous system.
Endoscopic ultrasound guided fine‐needle aspiration diagnosis of duodenal high grade neuroendocrine carcinoma underlying a villous adenoma: Report of a case
Authors: Tasso David M. , Attam Rajeev , Aslan Deniz L. , Pambuccian Stefan E. 
Published: December 2010

AbstractEndoscopic ultrasound guided fine‐needle aspiration biopsy is a reliable and accurate method for the diagnosis of submucosal lesions of the gastrointestinal tract. We report the cytopathologic findings of a case of duodenal high‐grade neuroendocrine carcinoma in a 68‐year‐old woman who presented with melena and marked anemia, 45 years after kidney transplantation. Imaging studies performed in the work‐up of melena showed a duodenal mass, which on endoscopy proved to be an exophytic, villous duodenal lesion, 3 cm from the ampulla. Forceps biopsy of the exophytic lesion showed a villous adenoma. Endoscopic ultrasound additionally revealed an underlying submucosal lesion and EUS‐guided fine needle aspiration of this submucosal mass and of the enlarged mesenteric lymph nodes was diagnostic of a high‐grade neuroendocrine carcinoma. The aspirates showed abundant cellularity with tumor cells arranged in sheets and occasional loose clusters. The neoplastic cells had a moderate amount of pale cytoplasm and large round to oval hyperchromatic nuclei with focally prominent nucleoli. Mitoses, apoptotic bodies and necrotic debris were also present. The tumor cells were strongly and diffusely positive for cytokeratin AE1/AE3, synaptophysin and chromogranin and showed a very high proliferative fraction on Ki67 staining, supporting the diagnosis of a high‐grade neuroendocrine carcinoma. This is to our knowledge the first case of high‐grade neuroendocrine carcinoma of the duodenum diagnosed by EUS‐FNA. This case also emphasizes the diagnostic value of EUS‐FNA sampling of the submucosal and intramural component of villous tumors of the gastrointestinal tract when mucosal forceps biopsies show only benign findings. Diagn. Cytopathol. 2012. © 2010 Wiley Periodicals, Inc.
Necrotic granulomatous pseudotumor following metal‐on‐metal hip arthroplasty: A potential mimic of sarcoma on fine needle aspiration cytology
Authors: Singh Charanjeet , Kaplan Alesia , Pambuccian Stefan E. 
Published: December 2010

AbstractA 69‐year‐old female presented with left leg pain 4 months after total hip replacement for left hip joint protrusio acetabuli. A “cystic” mass lesion was identified radiologically in relation to the arthroplasty and an initial CT‐guided core needle biopsy showed a spindle cell proliferation with associated necrosis, interpreted as suspicious for malignancy. A repeat CT‐guided fine needle aspiration showed necrosis, “ghost” spindle cells, aggregates of histiocytes, giant cells, and inflammatory cells as well as scattered large atypical spindle cells. The simultaneously obtained core biopsy showed extensive necrosis with ghost spindle cells that was surrounded by CD68+ histiocytes, which in turn were surrounded by a predominantly CD3+, CD4+ lymphocytic infiltrate. A diagnosis of necrotic granulomatous pseudotumor was made after a diagnosis of sarcoma was initially entertained. This unusual tissue response is rarely seen after metal‐on‐metal arthroplasty, occurs more often in females and may represent a type‐IV hypersensitivity reaction incited by very small‐sized particulate metallic debris that forms haptens in association with serum proteins. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.
Clinical trials in New Zealand: Progress, people, and policies
Authors: Lockhart Michelle Marie , Babar Zaheer‐Ud‐Din , Garg Sanjay 
Published: December 2010

AbstractCompetition for clinical trial projects outsourced by the global pharmaceutical industry is increasing with more countries bidding to provide these services. A comprehensive review of the clinical trial landscape in New Zealand was conducted by analysing clinical trial applications, and interviewing senior industry representatives on their expertise, capabilities, knowledge management, and innovative behaviours, as well as the policies and factors that had influenced the development of the industry. The number of clinical trial application approvals increased from 33 in 1989/1990 to 113 in 2008/2009 indicating continued confidence of the pharmaceutical industry in placing clinical research projects in New Zealand. Much of this growth has been due to an increasing number of phase I and II trials as a result of the availability of new purpose‐built facilities. The sponsors of clinical trials in New Zealand have changed from predominantly representatives of the pharmaceutical industry to mainly local and overseas CROs. The industry representatives are very experienced with the range of capabilities expected for clinical trials. They prefer informal sources of knowledge acquisition and display innovative behaviours such as solving problems that cause others difficulty, teamwork, and project planning. A large number of factors have encouraged the clinical trials industry in New Zealand including quality sites and data, the western healthcare system, the high incidence of some diseases, and seasonal opposition to Europe and the United States. Respondents suggested policies and strategies to address the increasing threat from global competition. New Zealand has developed significant expertise in clinical research but it should continue to monitor its industry to ensure continued growth. Drug Dev Res 72: 299–304, 2011. © 2010 Wiley‐Liss, Inc.
A general predictive model for estimating monthly ecosystem evapotranspiration
Authors: Sun Ge , Alstad Karrin , Chen Jiquan , Chen Shiping , Ford Chelcy R. , Lin Guanghui , Liu Chenfeng , Lu Nan , McNulty Steven G. , Miao Haixia , Noormets Asko , Vose James M. , Wilske Burkhard , Zeppel Melanie , Zhang Yan , Zhang Zhiqiang 
Published: December 2010

AbstractAccurately quantifying evapotranspiration (ET) is essential for modelling regional‐scale ecosystem water balances. This study assembled an ET data set estimated from eddy flux and sapflow measurements for 13 ecosystems across a large climatic and management gradient from the United States, China, and Australia. Our objectives were to determine the relationships among monthly measured actual ET (ET), calculated FAO‐56 grass reference ET (ETo), measured precipitation (P), and leaf area index (LAI)—one associated key parameter of ecosystem structure. Results showed that the growing season ET from wet forests was generally higher than ETo while those from grasslands or woodlands in the arid and semi‐arid regions were lower than ETo. Second, growing season ET was found to be converged to within ± 10% of P for most of the ecosystems examined. Therefore, our study suggested that soil water storage in the nongrowing season was important in influencing ET and water yield during the growing season. Lastly, monthly LAI, P, and ETo together explained about 85% of the variability of monthly ET. We concluded that the three variables LAI, P, and ETo, which were increasingly available from remote sensing products and weather station networks, could be used for estimating monthly regional ET dynamics with a reasonable accuracy. Such an empirical model has the potential to project the effects of climate and land management on water resources and carbon sequestration when integrated with ecosystem models. Copyright © 2010 John Wiley & Sons, Ltd.
Syntheses and Biological Properties of Brefeldin Analogues
Authors: Förster Sebastian , Persch Elke , Tverskoy Olena , Rominger Frank , Helmchen Günter , Klein Christian , Gönen Basak , Brügger Britta 
Published: December 2010

AbstractTotal and partial syntheses of brefeldin analogues are described. (6R)‐Hydroxy‐BFA (5) was obtained through a total synthesis from (1S,2R)‐2‐[(trityloxy)methyl]cyclopent‐3‐ene‐1‐carbonitrile (cis‐8) in 13 steps. The BFA lactam analogue 6 was prepared via the key building block 25, which was accessed in four steps from BFA (1). (7S)‐Amino‐BFC (7) was obtained from 7‐dehydro‐BFA (3) by reductive amination. The structures of the brefeldin analogues were determined by X‐ray analyses. The activities of the brefeldin analogues in blocking protein traffic between the endoplasmatic reticulum and the Golgi apparatus were determined both for mammalian cells and for plant cells. Molecular mechanics calculations and docking into the Arf1‐GEF protein complex, an established receptor of BFA, were carried out.
A Configurationally Stable Chiral Concave Imidazolinium Salt
Authors: Reimers Tim , Näther Christian , Lüning Ulrich 
Published: December 2010

AbstractStarting from symmetric bis‐ortho‐alkenyl‐substituted aniline 11 and unsymmetric bis‐alkenyl‐substituted aminonaphthalene 12, imidazolinium salt 17 has been prepared. Salt 17 was cyclized by ring‐closing metathesis, and hydrogenation gave axially chiral N‐heterocyclic carbene precursor 19. The configurational stability of 19 was proven by temperature‐dependent NMR studies and also by the use of Λ‐BINPHAT as a chiral shift reagent. Compound 19 was also characterized by single‐crystal X‐ray diffraction.
Fully integrated PDMS/SU‐8/quartz microfluidic chip with a novel macroporous poly dimethylsiloxane (PDMS) membrane for isoelectric focusing of proteins using whole‐channel imaging detection
Authors: Shameli Seyed Mostafa , Elbuken Caglar , Ou Junjie , Ren Carolyn L. , Pawliszyn Janusz 
Published: December 2010

AbstractA fully integrated polydimethylsiloxane (PDMS)/modified PDMS membrane/SU‐8/quartz hybrid chip was developed for protein separation using isoelectric focusing (IEF) mechanism coupled with whole‐channel imaging detection (WCID) method. This microfluidic chip integrates three components into one single chip: (i) modified PDMS membranes for separating electrolytes in the reservoirs from the sample in the microchannel and thus reducing pressure disturbance, (ii) SU‐8 optical slit to block UV light (below 300 nm) outside the channel aiming to increase detection sensitivity, and (iii) injection and discharge capillaries for continuous operation. Integration of all these components on a single chip is challenging because it requires fabrication techniques for perfect bonding between different materials and is prone to leakage and blockage. This study has addressed all the challenges and presented a fully integrated chip, which is more robust with higher sensitivity than the previously developed IEF chips. This chip was tested by performing protein and pI marker separation. The separation results obtained in this chip were compared with that obtained in commercial cartridges. Side‐by‐side comparison validated the developed chip and fabrication techniques.
Generator step‐up transformer post mortem assessment
Authors: Susa D. , Liland K.B. , Lundgaard L. , Vårdal G. 
Published: December 2010

AbstractThe condition assessment of the 190 MVA, OFWF, step‐up generator transformer was performed by the mapping of degree of polymerization (DP). The transformer was taken out of service after 36 years and the active part, (transformer core and windings), was removed from the tank for close examination due to the major thermal fault at the transformer core. The transformer insulation consisted of two different materials, i.e. winding insulation was the thermally upgraded paper and spacer‐pressboard system was Kraft paper. The temperature mapping is also shown, where the temperature estimation is based on the paper aging kinetics, transformer loading and insulation operating history. New equation for the relative aging rate is given considering all insulation conditions providing possibility of counting transformer loss‐of‐life more accurately. Copyright © 2010 John Wiley & Sons, Ltd.
Impact of real case transmission systems constraints on wind power operation
Authors: Vallée François , Lobry Jacques , Deblecker Olivier 
Published: December 2010

AbstractIn this paper, a general strategy is proposed in order to introduce in a realistic way wind power into a HLII (bulk power system) nonsequential Monte Carlo adequacy study with economic dispatch. By use of the implemented solution, wind power can consequently be confronted to operational constraints related to high‐powered thermal units, nuclear parks or cogeneration. Moreover, in order to optimize the large‐scale integration of wind power production, the required reinforcements on a given electrical grid can also be evaluated on basis of the presented developments. The elaborated strategy can practically be applied to every kind of nonsequential Monte Carlo approach used to technically analyze a given transmission system. In the context of this work, the proposed solution has been implemented into the simulation tool Scanner© (property of Tractebel Engineering – Gaz de France – Suez company). Finally, in order to point out the efficiency and the usefulness of the proposed wind power model, the developed simulation tool has been firstly applied to an academic test system: the Roy Billinton test system (RBTS). Afterwards, in order to fully access the large offshore wind potential in the North Sea, the same tool has been used to evaluate the onshore reinforcements required in the Belgian transmission network. Copyright © 2010 John Wiley & Sons, Ltd.
Detecting cognitive impairment in individuals at risk for cardiovascular disease: the “Clock‐in‐the‐Box” screening test
Authors: Grande Laura J. , Rudolph James L. , Milberg William P. , Barber Colleen E. , McGlinchey Regina E. 
Published: December 2010

AbstractObjectiveThe purpose of this study was to evaluate the performance on the Clock‐in‐the‐Box (CIB), a screening measure for cognitive function, relative to neuropsychological testing in an older population with cardiovascular risk.MethodsA prospective cohort of older patients (>50 years) with cardiovascular risk was recruited to perform the CIB and complete a brief neuropsychological battery consisting of Trailmaking tests, the Hopkins Verbal Learning Test (HVLT), and fluency tasks. Performance on the CIB was scored according to standard criteria (range 0–8, 0–worst). The performance on the total CIB, working memory subscale (CIB–WM), and planning/organization (COB–PO) was compared to neuropsychological measures.ResultsThe cohort (n = 127) was older (age 67 ± 7 years) and diverse with 33% female (n = 42) and 42% non‐white race (n = 53). Cardiac risk factors were prevalent: hypertension (83%), hyperlipidemia (74%), overweight (84%), diabetes (48%), prior cardiac disease (39%), and smoking (11%). The CIB (mean 6.5 ± 1.3) took 84 ± 21 s on average to complete and had good inter‐rater reliability (κ = 0.809, p < 0.01). The CIB–WM subscale was significantly correlated with performance on Trailmaking B and HVLT learning, recall, and recognition. The CIB–PO subscale was significantly associated with semantic and phonemic fluency, Trailmaking B, and HVLT learning and recall. In regression modeling, CIB–WM significantly predicted performance on HVLT learning, recall, and retention. CIB–PO subscale predicted performance on Trailmaking B, HVLT learning, and HVLT recall.ConclusionsThe CIB is a brief cognitive screening instrument with good reliability and predictive validity in a CV risk population. The CIB–WM and CIB–PO subscales could provide utility for clinicians. Published in 2010 by John Wiley & Sons, Ltd.
Over‐ and under‐diagnosis of dementia in ethnic minorities: a nationwide register‐based study
Authors: Nielsen T. R. , Vogel A. , Phung T. K. T. , Gade A. , Waldemar G. 
Published: December 2010

AbstractObjectiveAmong dementia professionals in several European countries, it is believed that dementia is under‐diagnosed and under‐treated to a greater extent among ethnic minorities than in the native population. It is unknown whether this belief holds true. The objective of this study was to compare the prevalence of register‐based dementia diagnoses in the largest ethnic minority groups in Denmark with the prevalence of register‐based dementia diagnoses in the general Danish population.MethodsBy linking the Danish hospital registers with the Danish Civil Registration System, nationwide dementia cases for three main ethnic minorities were identified. Age‐ and gender‐specific prevalence rates for dementia were calculated and compared to previously published data for the general population.ResultsThe study population consisted of 68 219 persons aged 20 and older. A total of 174 dementia cases were identified. The mean age at diagnosis was 57.7 years (SD = 16.2). Compared to the general population, there was a higher prevalence of dementia among those younger than 60 years, and a markedly lower prevalence of dementia among those 60 years and older.ConclusionsDementia is under‐diagnosed to a greater extent among ethnic minorities in the age group 60 years and older but is over‐diagnosed in the age group younger than 60 years. Several factors may contribute to this pattern, including cultural differences in help‐seeking behaviour, and problems in navigating the health‐care system. Furthermore, cross‐cultural assessment of dementia can be difficult because of language barriers and cultural differences. Copyright © 2010 John Wiley & Sons, Ltd.