bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occurrence of premature battery depletion in a large multicentre registry of subcutaneous cardioverter-defibrillator patients
Authors: Wörmann Jonas , Strik Marc , Jurisic Stjepan , Stout Kara , Elrefai Mohamed , Becher Nina , Schaer Beat , van Stipdonk Antonius , Srinivasan Neil T , Ploux Sylvain , Breitenstein Alexander , Kron Jordana , Roberts Paul R , Toennis Tobias , Linz Dominik , Dulai Rajdip , Hermes-Laufer Julia , Koneru Jay , Erküner Ömer , Dittrich Sebastian , van den Bruck Jan-Hendrik , Schipper Jan-Hendrik , Sultan Arian , Rosenberger Kerstin D , Steven Daniel , Lüker Jakob 
Published: June 2024

Abstract

Aims
Subcutaneous implantable cardioverter-defibrillators (S-ICDs) have become established in preventing sudden cardiac death, with some advantages over transvenous defibrillator systems, including a lower incidence of lead failures. Despite technological advancements, S-ICD carriers may suffer from significant complications, such as premature battery depletion (PBD), that led to an advisory for nearly 40 000 patients. This multicentre study evaluated the incidence of PBD in a large set of S-ICD patients.

Methods and results
Data from patients implanted with S-ICD models A209 and A219 between October 2012 and July 2023 across nine centres in Europe and the USA were reviewed. Incidence and implications of PBD, defined as clinically observed sudden drop in battery longevity, were analysed and compared to PBD with the definition of battery depletion within 60 months. Prospectively collected clinical data were obtained retrospectively from medical records, device telemetry, and manufacturer reports. This registry is listed on ClinicalTrials.gov (NCT05713708). Of the 1112 S-ICD devices analysed, 547 (49.2%) were equipped with a potentially affected capacitor linked to PBD occurrence, currently under Food and Drug Administration advisory. The median follow-up time for all patients was 46 [inter-quartile range (IQR) 24–63] months. Clinically suspected PBD was observed in 159 (29.1%) of cases, with a median time to generator removal or replacement of 65 (IQR 55–72) months, indicative of significant deviations from expected battery lifespan. Manufacturer confirmation of PBD was made in 91.7% of devices returned for analysis. No cases of PBD were observed in devices that were not under advisory.

Conclusion
This manufacturer-independent analysis highlights a notable incidence of PBD in patients equipped with S-ICD models under advisory, and the rate of PBD in this study corresponds to the rate currently estimated by the manufacturer. To the best of our knowledge, this provides the largest contemporary peer-reviewed study cohort investigating the actual incidence of PBD in S-ICD patients. These findings emphasize the importance of post-market registries in collaboration between clinicians and the manufacturer to optimize safety and efficacy in S-ICD treatment.
On the importance of scale in evolutionary quantitative genetics
Authors: Hansen Thomas F , Holstad Agnes , Houle David , Pélabon Christophe 
Published: June 2024

Abstract
The informed use of scales and units in evolutionary quantitative genetics is often neglected, and naïve standardizations can cause misinterpretations of empirical results. A potentially influential example of such neglect can be found in the recent book by Arnold (2023. Evolutionary quantitative genetics. Oxford University Press). There, Arnold championed the use of heritability over mean-scaled genetic variance as a measure of evolutionary potential arguing that mean-scaled genetic variances are correlated with trait means while heritabilities are not. Here, we show that Arnold’s empirical result is an artifact of ignoring the units in which traits are measured. More importantly, Arnold’s argument mistakenly assumes that the goal of mean scaling is to remove the relationship between mean and variance. In our view, the purpose of mean scaling is to put traits with different units on a common scale that makes evolutionary changes, or their potential, readily interpretable and comparable in terms of proportions of the mean.
Climate sensitive tree growth modelling of Myrocarpus frondosus in Southern Brazil using tree-ring time series and distributed generalized additive lag models
Authors: Schons Cristine Tagliapietra , Nothdurft Arne , Ritter Tim , Fleig Frederico Dimas 
Published: June 2024

Abstract
Climate change is expected to strongly affect the functioning of tropical and subtropical forest ecosystems around the globe, and tree-ring analysis is proving increasingly useful for understanding the changing dynamics in these environments. However, traditional dendroecological methods were not originally designed to jointly consider inter-annual and inter-tree variations, often assuming linear growth-climate relationships, and limiting the potential to address in-deep questions regarding the tree growth sensitivity to environmental drivers. In the present study, we applied a flexible generalized additive model to assess the climate-sensitivity of the species Myrocarpus frondosus Allemão growing in a subtropical Atlantic Forest (AF) site in southern Brazil. Tree-ring width time series from 117 stem cores together with monthly climate data of temperature and precipitation covering the period from 1968 to 2021 were used for model construction. The model was designed to simultaneously encompass detrending, to capture nonlinear effects of climate variables and their interactions and to predict mean tree-ring widths for the species. Based on a distributed lag model approach, we also tested the influence of different lengths of lagged climate series over the model accuracy. Both precipitation and temperature proved to be strong drivers of M. frondosus radial growth in the subtropical AF. An interaction effect between these regressor variables revealed a likely water stress scenario arising from warm and dry summer conditions, with strongly negative impacts for the species. Detrimental impacts on tree dormancy period can also be expected due to milder winters, with legacy effects on the radial increments across two subsequent years. In addition to monitoring, the approach applied here meets the needs for more robust predictions of the impacts of future climate conditions on species and communities, contributing to efforts aimed at the management and conservation in tropical and subtropical ecosystems, particularly in the AF.
Medicare Fee-For-Service Spending for Fall Injury and Nonfall Events: The Health, Aging, and Body Composition Study
Authors: Xue Lingshu , Napoleone Jenna M , Winger Mary E , Boudreau Robert M , Cauley Jane A , Donohue Julie M , Newman Anne B , Waters Teresa M , Strotmeyer Elsa S 
Published: June 2024

Abstract

Background and Objectives
Fall injuries are prevalent in older adults, yet whether higher spending occurs after nonfracture (NFFI) and fracture is unknown. We examined whether incident fall injuries, including NFFI and fractures, were associated with higher Medicare spending in 12 months after incident events in older adults.

Research Design and Methods
The Health, Aging, and Body Composition Study included 1 595 community-dwelling adults (53% women, 37% Black; 76.7 ± 2.9 years) with linked Medicare Fee-For-Service (FFS) claims at 2000/01 exam. Incident outpatient and inpatient fall injuries (N = 448) from 2000/01 exam to December 31, 2008 were identified using the first claim with a nonfracture injury diagnosis code with a fall E-code, or a fracture diagnosis code with/without an E-code. Up to 3 participants without fall injuries (N = 1 147) were matched on nonfall events to 448 participants in the fall injury month. We calculated the change in monthly FFS spending in 12 months before versus after index events in both groups. Generalized linear regression with centered outcomes and gamma distributions examined the association of prepost expenditure changes with fall injuries (including NFFI and fractures) adjusting for related covariates.

Results
Monthly spending increased after versus before fall injuries (USD$2 261 vs $981), nonfracture (N = 105; USD$2 083 vs $1 277), and fracture (N = 343; USD$2 315 vs $890) injuries (all p &lt; .0001). However, after adjusting for covariates in final models, fall injuries were not significantly associated with larger increases in spending/month versus nonfall events (differential increase: USD$399.58 [95% CI: −USD$44.95 to $844.11]). Fracture prepost change in monthly spending was similar versus NFFI (differential increase: USD$471.93 [95% CI: −USD$21.17 to $965.02]).

Discussion and Implications
Although substantial increases occurred after injuries, with fracture and NFFI increasing similarly, changes in monthly spending after fall injury were not different compared to nonfall events. Our results contribute to the understanding of subsequent spending after fall injury that may inform further research on fall injury-related health care spending.
The Perspective of Residents Living With Dementia Toward Their Built Environment: A Walking Interview Study in German Nursing Homes
Authors: Fahsold Anne , Schmüdderich Kathrin , Roes Martina , Verbeek Hilde , Palm Rebecca , Holle Bernhard 
Published: June 2024

Abstract

Background and Objectives
In long-term care, the built environment can help residents maintain activities of daily living and thus positively influence their quality of life. The adequacy of the built environment can be systematically assessed using assessment tools. The German Environmental Audit Tool (G-EAT) was translated and psychometrically tested for the German setting. Previous research has shown that the perspective of people living with dementia has not been fully considered in this adaptation. To explore the residents’ perspective, the question of how residents living with dementia experience the built environment of nursing homes was investigated.

Research Design and Methods
Walking interviews were conducted with residents. Inclusion criteria for participation were the presence of dementia (medically diagnosed or indicated by symptoms) and the ability to express themselves verbally in German. For data analysis, the audio material was transcribed and supplemented by the researchers’ field notes and photographs. Data analysis followed an interpretative phenomenological approach.

Results
Fourteen residents from 2 nursing homes participated in the walking interviews. A total of 3 themes were identified: (1) being able to maintain the feeling “to refurnish” or having to let it go, (2) experiencing the limits and potentials of being independent because of the built environment, and (3) living in a community of residents.

Discussion and Implications
The perspective of the living environment of people living with dementia in nursing homes adds to the knowledge of assessment-based data. Boundaries between physical and social environments are experienced as fluid by residents. They do not see their living space as limited to their living unit but describe the nursing home as a living environment. This broadens the perspective of existing structural definitions in the setting.
The Association Between Grandchild Care and Biological Aging Among Middle-Aged and Older Adults in China
Authors: Xie Donghong , Wang Jiwen 
Published: June 2024

Abstract

Background and Objectives
Substantial evidence documents grandchild care is associated with self-reported health, life satisfaction, and depressive symptoms among middle-aged and older adults. However, little is known about the relationship between grandchild care and biological aging, especially in China, which emphasizes the unique cultural value of family. The current study sheds light on the biological consequence of grandchild care by examining the link between grandchild care and biological aging among middle-aged and older adults in China, and how gender and spousal involvement in caregiving affect this link.

Research Design and Methods
In a representative sample of Chinese adults aged 45–80 from the third wave of China Health and Retirement Longitudinal Study in 2015 (n = 3,384), we calculate biological age using Klemera–Doubal Method, and Ordinary Least Square models are used to examine the correlation between grandchild care and biological aging.

Results
High intensity of involvement in grandchild care is related to biological aging, and caring for grandchildren alone predicts greater biological aging. Compared with grandfathers, grandmothers lose more from grandchild care regardless of whether their husbands are involved in the care.

Discussion and Implications
Providing grandchild care should be a way to cope with age-related role discontinuity or loss, rather result in extra stress or burden for grandparents. Reducing the intensity of caregiving or increasing family support may attenuate the extent of biological aging.
Control or Compensation: Distorted Narrative and Aftermath of Article 17 CDSM
Authors: Woznica Ondřej 
Published: June 2024

Abstract
This article analyses the value gap argument and the legislative outcome of Art. 17 of the Directive on copyright in the Digital Single Market (CDSM). The analysis is based on a qualitative content analysis of key documents related to the value gap problem and entitlement analysis of the property and liability rules character of Art. 17.
The central theme of this article is the conflict between control and compensation. This ties into Peukert’s communication culture concept, which emphasizes exclusivity or access. Control and compensation are vital elements in the property and liability rules framework.
The first part explores the roots of the value gap argument and its connection to the proprietary paradigm of copyright. The content analysis of the value gap argument shows that it is built upon the property narrative of copyright.
The second part examines Art. 17 through the lens of property and liability rules, drawing on the framework developed by Calabresi and Melamed. The results show that Art. 17 has a mixed character, with a dominant property rule. However, when the real market dynamics are considered, the analysis reveals different results in different creative industries. Industries with strong collective management presence operate under liability rule schemes. As a result, authors in these industries benefit from ‘compensation without control’.
The article concludes that integrating liability rule mechanisms is crucial for promoting access and fair compensation. This is exemplified by Art. 17 and markets that function under liability rule organizations, where minor authors particularly stand to benefit.
A comparison between different models of delivering maternal cash transfers in Myanmar
Authors: Maffioli Elisa M , Tint Zaw Nicholus , Field Erica 
Published: June 2024

Abstract
As part of a randomized controlled trial conducted in Myanmar between 2016 and 2019, we explore the performance of a maternal cash transfer program across villages assigned to different models of delivery (by government health workers vs loan agents of a non-governmental organization) and identify key factors of success. Measures include enrolment inclusion and exclusion errors, failures in payment delivery to enrolled beneficiaries (whether beneficiaries received any transfer, fraction of benefits received and whether there were delays and underpayment of benefit amounts) and whether beneficiaries remained in the program beyond eligibility. We find that women in villages where government health workers delivered cash transfers received on average two additional monthly transfers, were 19.7% more likely to receive payments on time and in-full and were 14.6% less likely to stay in the program beyond eligibility. With respect to the primary health objective of the program—child nutrition—we find that children whose mother received cash by government health workers were less likely to be chronically malnourished compared to those whose mother received cash by loan agents. Overall, the delivery of cash transfers to mothers of young children by government health workers outperforms the delivery by loan agents in rural Myanmar. Qualitative evidence suggests two key factors of success: (1) trusted presence and past interactions with targeted beneficiaries and complementarities between government health workers’ expertise and the program; and (2) performance incentives based on specific health objectives along with top-down monitoring. We cannot exclude that other incentives or intrinsic motivation also played a role.
The geopolitics of technology standards: historical context for US, EU and Chinese approaches
Authors: Zúñiga Nicholas , Burton Saheli Datta , Blancato Filippo , Carr Madeline 
Published: June 2024

Abstract
This article provides a review of the historical trends that are shaping global competition for standard setting in emerging technologies. Specifically, it explores how the traditional rule-makers of international standardization, namely the United States and Europe, are responding to the rise of China in standard-setting. The article argues that three polities are adapting their standard-setting strategies to shifting power dynamics in the international technology order. To preserve its competitive advantage, the US is becoming more interventionist and proactive in setting technology standards. China has developed a long-term standardization strategy to bolster its domestic industrial development, increase its influence and reap greater profits from the process of rule-making. Finally, the EU is seeking a third way that strikes a balance between competition and cooperation to preserve values like interoperability, which have historically benefited its single market and the global economy at large. Our historical review shows that, while the three polities have different priorities and face distinct challenges, they all seem to converge towards a greater role for governments in standard-setting.
Protection of non-original objects generated by artificial intelligence: the Ukrainian copyright law approach
Authors: Bulat Nataliia 
Published: June 2024

Abstract
The Law of Ukraine ‘On Copyright and Related Rights’ of 1 December 2022 is the first attempt in the Ukrainian legislation to regulate relations concerning non-original objects generated by a computer programme (including artificial intelligence (AI)). The aim of the article is to analyse the approach to dealing with non-original objects generated by AI proposed by the Ukrainian copyright legislation. The paper provides a general overview of the Ukrainian copyright law approach to non-original objects generated by a computer programme. After that, special attention is paid to the meaning and scope of non-original objects generated by AI. Finally, the article discusses a question of who should be a holder of sui generis rights to non-original objects. Positively estimating the legislative novelty and the accuracy of terms ‘a non-original object generated by a computer programme’ and ‘works created by natural persons with using computer technologies’, the article provides some recommendations concerning art 33 of the Law of Ukraine ‘On Copyright and Related Rights’ interpretation and further legislation improvement.
DORAVIR: a French national survey of people with HIV-1 treated with an antiretroviral regimen including doravirine
Authors: Soulie Cathia , Balde Aliou , Fofana Djeneba , Charpentier Charlotte , Bonnafous Pascale , Sourice Justine , De Monte Anne , Avettand-Fenoel Véronique , Le Guillou-Guillemette Hélène , Bocket Laurence , Raymond Stéphanie , Marque Juillet Stéphanie , Trabaud Mary-Anne , Montes Brigitte , Maillard Anne , Hartard Cédric , Alessandri-Gradt Elodie , Brochot Etienne , Signori-Schmuck Anne , Assoumou Lambert , Marcelin Anne-Geneviève 
Published: June 2024

Abstract

Background
Doravirine is the latest NNRTI to be approved for the treatment of HIV-1 and has a different resistance profile from first-generation NNRTIs. Our aim was to investigate the virological efficacy of antiretroviral treatment including doravirine in people living with HIV-1 (PLWHIV), the factors associated with virological failure (VF) and those associated with the emergence of reverse transcriptase (RT) mutations in the case of VF.

Methods
A retrospective national survey of PLWHIV who were either naive or experienced on antiretroviral treatment including doravirine was conducted. VF was defined as two consecutive plasma viral loads (VLs) of ≥50 copies/mL or one VL of ≥200 copies/mL. Genotypic resistance tests were interpreted using the Stanford (v9.4.1) and ANRS (v33) algorithms.

Results
Of the 589 PLWHIV treated with a doravirine-containing regimen, 8.5% were naive and 91.5% had prior antiretroviral experience; 56.9% were infected with HIV-1 B subtype. Overall, 88.3% and 85.1% of participants were virologically controlled at Month (M)3 and M6 of doravirine treatment, respectively. In multivariable analysis, CRF02_AG subtype, higher zenith plasma HIV-1 RNA VL, doravirine initiation in the context of failure and baseline V179D mutation presence were associated with VF. Among 88 PLWHIV who experienced virological failure at M6, 15.9% had a median of 2 (IQR 1–3) HIV RT mutations. In multivariable analysis, the only factor associated with the occurrence of mutations was a genotypic sensitivity score that was not fully sensitive.

Conclusions
This study is one of the largest to characterize the virological efficacy of doravirine-containing regimens in clinical practice and to identify factors associated with VF or emergence of resistance mutations that should be considered in clinical management.
Analysis of PIK3CA mutations in the primary and recurrent tumors of hormone receptor positive/human epidermal growth factor receptor 2 negative breast cancer
Authors: Wang Yue , Li Xin , Zhang Shuang , Liang Li , Xu Ling , Liu Yinhua , Li Ting 
Published: June 2024

Abstract

Objective
Our aim was to compare the PIK3CA mutation status in matched primary and recurrent tumors of hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2−) breast cancer (BC) to gain insight into the optimization of patient selection and detection time for PIK3CA-targeted therapy.

Methods
The data were from 3035 patients with BC diagnosed at the Breast Disease Center, Peking University First Hospital, between January 2008 and December 2017. Matched primary and recurrent samples were profiled using amplification-refractory mutation system-polymerase chain reaction covering 11 mutational hotspots in PIK3CA.

Results
PIK3CA mutations were detected in 54.3% primary tumors and 48.6% corresponding recurrences. PIK3CA mutation was detected in 37.5% cases in the locoregional recurrent group and 40.0% of distant metastasis, without a statistical difference. Besides, PIK3CA mutations were concordant in 88.6% of the matched pairs. For patients treated with neoadjuvant chemotherapy, 100% concordance was observed. However, PIK3CA mutation was neither correlated with clinicopathological features nor associated with clinical outcomes.

Conclusions
Mutations in PIK3CA in HR+/HER2− BC generally progressed to recurrent tumors. The high concordance rate of PIK3CA mutation status between primary tumors and corresponding recurrences suggests that the detection of primary tumors could be a substitute approach when recurrent samples are not easily obtainable.