bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lactate-induced IGF1R protein lactylation promotes proliferation and metabolic reprogramming of lung cancer cells
Authors: Zhang Rong , Li Lulu , Yu Junyan 
Published: May 2024

Abstract
Lung cancer (LC) is regarded as a fatal cancer, and insulin-like growth factor 1 (IGF1) and its receptor (IGF1R) have been found to play a key role in regulating tumor glycolytic metabolism. The aim of this study is to investigate LC proliferation regulated by metabolite-mediated IGF1R lactylation. IGF1R was highly expressed in LC tissues and cells, and the effects of IGF1R on protein stability were inhibited by Lactate dehydrogenase A (LDHA) inhibition. Moreover, the tightness of IGF1R binding to IGF1 was also enhanced by exogenous lactic acid but suppressed by LDHA silencing, while cell viability and proliferation were promoted by over-expression of IGF1R. Exogenous lactic acid further exacerbated the effects of the IGF1R gene, while LDHA knocking down reduced the IGF1R-induced malignant behaviors. The IGF1R and exogenous lactic acid were also found to increase extracellular acidification rate (ECAR) and decrease oxygen consumption rate to regulate glycolysis, which was inhibited by LDHA deficiency in LC cells. The study concluded that IGF1R-mediated aggressive behaviors of LC cells were associated with higher levels of IGF1R lactylation. Moreover, lactic acid can improve the protein stability of the IGF1R oncogene, thus promoting glycolysis and generating lactic acid, forming a closed loop. Therefore, targeting IGF1R is envisaged to provide a novel strategy for developing therapeutic agents against LC.
Role of Embinin in the reabsorption of nucleus pulposus in lumbar disc herniation: Promotion of nucleus pulposus neovascularization and apoptosis of nucleus pulposus cells
Authors: Meng Yingying , Liu Wei , Liu Haifeng , Yu Chengwei 
Published: May 2024

Abstract
Reabsorption of the nucleus pulposus (NP) in lumbar disc herniation (LDH) refers to the natural absorption or even complete disappearance of LDH. In order to better treat LDH, it is necessary to further study its mechanism and develop new therapeutic drugs. Clematidis Radix Et Rhizoma is a ranunculus family plant which has multiple biological activities, and Embinin is one of its bioactive ingredients. However, its effects on LDH were unclear. In this study, the role of Embinin was investigated in LDH rat models. LDH model was established by lumbar epidural insertion of tail disc. Our results showed that Embinin promoted lumbar disc neovascularization, induced apoptosis of NP cells in LDH rats, and promoted lumbar disc resorption. Furthermore, mechanistic study showed that Embinin activated the cAMP pathway in the rat models. In conclusion, Embinin has the potential to serve as a drug for the treatment of LDH.
Novas formas de olhar. Fotografias coloniais em exposições portuguesas na atualidade
Authors: Burgert Anne 
Published: May 2024

Resumo
Este artigo debate o efeito que o uso de fotografias coloniais tem quando são utilizadas em exposições hodiernas. Analisam-se as condições e a perspetiva sob a qual foram tiradas e a exatidão — ou falta dela — das imagens no que toca à representação colonial e do Império português. Analisa-se também qual é o efeito que as fotografias têm quando são hoje apresentadas em exposições diversas. Procura-se mostrar que, com a devida distância temporal e consciência histórica, as fotografias coloniais motivam uma reescrita do conceito de Império.
“A formidavel confusão da natureza”: écfrase e ecopoética na reescrita do Império português no romance O terremoto de Lisboa (1874) de Pinheiro Chagas
Authors: González Danae Gallo 
Published: May 2024

Resumo
Este artigo analisa o romance O terremoto de Lisboa (1874) de Manuel Pinheiro Chagas (1842–1895), uma obra maioritariamente negligenciada pela crítica literária. Após uma revisão do estado da arte e uma justificação da pertinência da minha análise, será feita um close reading ecopoético da écfrase com que o terramoto é representado. Pretende-se examinar a reescrita nesta obra da catástrofe e da crise que o terramoto de 1755 provocou na capital do Império português, pouco depois do primeiro centenário do terremoto de Lisboa e setenta anos após a independência do Brasil (1822).
Computed tomography–guided percutaneous cryoablation of hereditary adrenal pheochromocytoma in three patients
Authors: Griffing Emily , Reading Brenton , De Luca Francesco , Agne Daniel , Juang David , Halpin Kelsee 
Published: May 2024

Abstract

Objectives
Pheochromocytomas (PHEO) are neuroendocrine tumors rarely diagnosed in children. We are reporting on the management challenges of three adolescent patients who present with hereditary PHEO.

Case presentation
The index patient and his male sibling presented with bilateral PHEO, while a third patient presented with a unilateral PHEO, all associated with von Hippel–Lindau (VHL) syndrome. The patients were treated with computed tomography (CT)-guided percutaneous cryoablation (CRA) of the adrenal lesions, with varying degrees of success.

Conclusions
CT-guided percutaneous CRA of hereditary PHEO has not been reported in the pediatric population and may represent a novel treatment strategy that reduces the risk of intraprocedural complications and adrenal insufficiency (AI).
Silting modules over a class of Morita rings
Authors: Asefa Dadi , Xu Qingbing 
Published: May 2024

Abstract
Let

Δ
=

A

N

B

A

M

A

B

B

\Delta =\left(\begin{array}{cc}A& {}_{A}N_{B}\\ {}_{B}M_{A}& B\end{array}\right)

be a Morita ring, where

M

⊗

A

N
=
0
=
N

⊗

B

M

M{\otimes }_{A}N=0=N{\otimes }_{B}M

. Let

X

X

be left

A

A

-module and

Y

Y

be left

B

B

-module. We prove that

(

X
,
M

⊗

A

X
,
1
,
0

)

⊕

(

N

⊗

B

Y
,
Y
,
0
,
1

)

\left(X,M{\otimes }_{A}X,1,0)\oplus \left(N{\otimes }_{B}Y,Y,0,1)

is a silting module if and only if

X

X

is a silting

A

A

-module,

Y

Y

is a silting

B

B

-module,

M

⊗

A

X

M{\otimes }_{A}X

is generated by

Y

Y

, and

N

⊗

B

Y

N{\otimes }_{B}Y

is generated by

X

X

. As a consequence, we obtain that if

M

A

{M}_{A}

and

N

B

{N}_{B}

are flat, then

(

X
,
M

⊗

A

X
,
1
,
0

)

⊕

(

N

⊗

B

Y
,
Y
,
0
,
1

)

\left(X,M{\otimes }_{A}X,1,0)\oplus \left(N{\otimes }_{B}Y,Y,0,1)

is a tilting

Δ

\Delta

-module if and only if

X

X

is a tilting

A

A

-module,

Y

Y

is a tilting

B

B

-module,

M

⊗

A

X

M{\otimes }_{A}X

is generated by

Y

Y

, and

N

⊗

B

Y

N{\otimes }_{B}Y

is generated by

X

X

.
Thermo-mechanical characteristics of spent coffee grounds reinforced bio-composites
Authors: Yanen Cenk 
Published: May 2024

Abstract
This research examines the incorporation of spent coffee grounds (SCGs) into composite materials utilizing a three-part system composed of modified castor oil, polyester resin, and SCGs. The objective is to assess the mechanical, microstructural, and thermal characteristics of the resultant composites. The composite specimens underwent a thorough preparation and were tested through a battery of procedures comprising tensile testing, shore D hardness testing, SEM, FT-IR, and thermal conductivity measurements. Tensile testing revealed higher mechanical resilience, reinforcing the desirable properties of SCGs. The 5 % SCG-reinforced sample exhibited the highest tensile strength value, with a 41.85 % increase observed in comparison to the pure sample. The results of shore D hardness tests demonstrated that there was no significant change in material hardness up to 3 % additive content. However, a decrease in hardness was observed at higher additive rates. At a 7 % additive rate, there was a 2.82 % decrease in material hardness. Furthermore, the application of scanning electron microscopy (SEM) analysis has revealed the microstructural features of the composite matrix, which have highlighted the distribution of SCGs within it. The successful implementation of SCGs has also been verified by means of Fourier transform infrared (FT-IR) analysis. Finally, based on thermal conductivity measurements, it has been determined that SCGs are suitable for thermal insulation purposes. This study represents a significant contribution to the field of sustainable materials science, emphasising the potential benefits of SCGs in improving the effectiveness of composite materials.
In situ synthesis of reduced graphene oxide/SnIn4S8 nanocomposites with enhanced photocatalytic performance for pollutant degradation
Authors: Wang Zhonghui , Gao Qiang , Luo Haihang , Fan Haojun , Chen Yi , Xiang Jun 
Published: May 2024

Abstract
A type of reduced graphene oxide (rGO)/SnIn4S8 (SIS) nanocomposites was successfully fabricated by a facile and efficient microwave-assisted method. Their morphology, structure, composition, and optical performance were investigated by different analytical techniques, respectively. The results indicated that rGO had an important effect on the structure of photocatalysts. As the content of rGO increases, the unchin-like microsphere structure of rGO/SIS evolved gradually into aggregated nanosheet structure. The photocatalytic degradation experiments were carried out under visible light irradiation. The results demonstrated rGO/SIS-2 nanocomposites exhibited higher photocatalytic activity toward the degradation of RhodamineB than that of SIS, rGO/SIS-1 as well as rGO/SIS-3. Meanwhile, the mineralization efficiency of Rhodamine B (RhB) can reach up to 73.8% within 30 min. Interestingly, rGO/SIS-2 nanocomposites exhibited excellent recycle stability with 96% removal efficiency of RhB after three cycles. The enhanced photocatalytic activity of rGO/SIS-2 nanocomposites should be attributed to the strong interaction of rGO and SIS, the decrease of band gap energy, the enhanced visible light absorption, and excellent electrons’ mobility of rGO, thereby promoting charge separation. Finally, the mechanism of rGO/SIS nanocomposites for the degradation of RhB has been also proposed. This work provides a facile and efficient pathway to prepare SIS-based nanocomposites with enhanced catalytic efficiency by combining the advantages of microwave-assisted heating and incorporating carbon-based nanomaterials for the degradation of organic pollutants in visible light irradiation.
Mucocutaneous Manifestations Reported by Inflammatory Bowel Disease Patients in University Hospital
Authors: Jonaitytė Ieva Renata , Karpavičiūtė Vita , Kiudelis Gediminas , Kupčinskas Juozas , Jonaitis Laimas 
Published: May 2024

Background: Inflammatory bowel disease (IBD)` may affect organs outside the intestines, it is called extraintestinal manifestations of IBD. Data on the prevalence of mu-cocutaneous manifestations in IBD patients are very limited, therefore, the aim of this study was to assess the prevalence of skin and mucosal lesions and to determine the relationship with demographic factors, clinical features, and systemic treatment.Materials and methods: Prospective study included 162 out-patients with IBD who were managed in the tertiary care center. Ulcerative colitis (UC) was diagnosed in 117 patients, Crohn‘s disease (CD) in 45. Patients completed the questionnaire containing demographic and IBD data, questions about mucocutaneous lesions (in past or present state).Results: Overall mucocutaneous lesions were reported by 48.1% of IBD patients. Skin lesions were reported by 40.7% of patients, oral mucosal lesions were reported by 16.7%, without significant differences between sexes or IBD types. In 47 (29%) of patients, skin lesions appeared together with IBD or during the course of the disease. The most common skin lesions were psoriasis (8.0%), erythema nodosum (5.6%), pyoderma gangrenosum and acne (3.7% each). UC patients mostly reported about psoriasis (9.4%), while CD patients about erythema nodosum (11.1%). There were more frequent skin lesions in patients with more extensive UC type (p = 0.01), while no difference was noticed between different types of CD. The average duration of IBD in patients with skin lesions was similar to those without lesions (9.3±6.7 vs. 9.4±6.7 years).Conclusions: Mucocutaneous lesions were reported by 48.1% of inflammatory bowel disease patients. The frequency of mucocutaneous lesions does not differ significantly between UC and CD, and a longer duration of illness is not a predictive factor for the appearance of lesions. More extensive UC is related to higher frequency of skin lesions.
Erratum noteThe title, author's name, and abstract have been updated to reflect the correct information following a typographical error during typesetting. We apologize for any inconvenience caused by these errors. Corrections were made on 2024-09-01.
A new species of the genus Hyalesthes Signoret, 1865 (Hemiptera: Fulgoroidea: Cixiidae) from the Russian Black sea coast – Western Mediterranean faunal element in the Caucasus
Authors: Gnezdilov Vladimir M. , Orlov Oleg V. 
Published: May 2024

AbstractA new species, Hyalesthes (Homalesthes) sagittus sp. n., of the family Cixiidae (Cixiinae, Pentastirini) is described from the Krasnodar Territory. The new species belongs to the Hyalesthes productus species group known from the Western Mediterranean and the Middle East. Natural disjunctive Western Mediterranean – Caucasian distribution as well as unintentional introduction of Auchenorrhyncha taxa are discussed.
Design of the intensification method with the help of FracCADE software
Authors: Rubel Victoriia , Pshyk Vadym 
Published: May 2024

The object of research in the work is the FracCADE software, with which it is possible to simulate the process of hydraulic fracturing and well field, on which the intensification method is designed. This hydraulic fracturing simulator was developed by Schlumberger Ltd. based on proven physical principles of hydraulic fracturing to optimize the treatment process and proven in practice. The system includes a range of hydraulic fracturing models, from 2D models to extensive 3D simulations with lateral communication. It includes a number of complementary modules for fracturing fluid and proppant optimization, injection scheduling, real-time monitoring, pressure equalization, production forecasting and economic evaluation. Some models allow simulating the geometry of the fracture, solving proppant concentration problems, and simulating possible shielding due to proppant covering the fracture or the dehydration process.
Hydraulic fracturing remains one of the main engineering tools for increasing the productivity of wells. The effect is achieved due to:
– creation of a conductive channel (fracture) through the damaged (contaminated) zone around the well, in order to penetrate beyond its boundaries;
– spreading of the channel (fracture) in the formation to a considerable depth in order to further increase the productivity of the well;
– creation of a channel (fracture), which would allow changing, influencing the fluid flow in the formation.
In the latter case, fracturing really becomes an effective tool that allows to manage the operation of the reservoir (in particular, change its filtering characteristics) and implement long-term strategic development programs. The concept of hydraulic fracturing is quite simple. In general, for relatively simple geology, the physical foundations of fracturing theory are fairly well developed and tested. For the most part, the difficulties boil down to two problems: the real geological conditions and the complex multidisciplinary nature of the fracturing process itself.
The process of designing fracturing in order to achieve a certain result is closely related to rock mechanics (which affects the geometric parameters of the fracture), fluid hydromechanics (in which the tasks of controlling the flow of the working fluid and placing the proppant in the fracture are solved) and chemistry, which determines the behavior of materials, which are used during hydraulic fracturing. Moreover, the hydraulic fracturing project must take into account the physical limitations imposed by the specifics of the real deposit and well. In addition, to achieve the desired results, the fracturing operation must be carried out in strict accordance with the calculations (that is, a complete cycle in which each operation plays its role).
Analysis of combined processing method of phosphate minerals from the Kef Essenoun deposit
Authors: Attafi Imane , Idres Abdelaziz , Mekti Zohir , Bouras Amina , Benselhoub Aissa , Merzeg Farid Ait , Dovbash Nadiia , Bellucci Stefano 
Published: May 2024

Currently, the processing of beige and black phosphates only concerns the main sub-layers, while the other sub-layers (lower and upper for beige phosphate and the upper for black phosphate) are considered waste rock and stored near the complex. Therefore, the object of this research is the use of mixtures of three beige phosphate sub-layers and two black phosphate sub-layers as a feed fraction for the calcination and reverses flotation processes. This research work aims to characterise and treat two types of phosphate: one beige with the sub-layers (main, lower and upper) and the other black with the sub-layers (main and upper) in order to have better recovery of P2O5.
The working methodology consists of a series of sample preparation operations and characterization of the two types of beige and black phosphate. This characterization includes a petrographic study, a granulochemical analysis, an X-ray diffraction (XRD), a scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS), and an atomic adsorption spectrophotometry (SAA), an auto analyzer (AA), a Bernard calcimeter. These analyzes allow on the one hand to identify the mineral phases in quantitative and qualitative manner, and on the other hand to choose the process for treating phosphates from the Kef Essenoun–Tebessa deposit.
The combined method of treatment by calcination followed by reverse flotation gave satisfactory results. The P2O5 content reaches 33.88 % for beige phosphate and 33.13 % for black phosphate.
The stored waste rock represents a problem for the company; this waste rock contains fairly high levels of phosphate. The treatment of the mixture of the main sub-layers with these waste rocks makes it possible to obtain a better recovery of P2O5, a better economic profitability of the Djebel Onk mining complex and an environmental impact in the region.
Study of the feasibility of valorizing phosphate ore by electrostatic separation
Authors: Derrardjia Nesrine , Nettour Djamel , Chettibi Mohamed , Chaib Rachid , Zeghloul Thami , Dascalescu Lucien , Aouimeur Djillali 
Published: May 2024

The object of this research is the phosphate serves, as a fundamental and crucial raw material with diverse applications, primarily utilized in producing phosphoric acid and fertilizers. However, dolomitic impurities within the ore can greatly impede its effectiveness. Therefore, it is essential to minimize these impurities to the lowest feasible levels to mitigate their adverse effects. This ensures optimal performance and quality in various industries reliant on phosphate, promoting efficiency and sustainability in the production process. Through a comprehensive assessment, it becomes feasible to gauge the enrichment potential and propose viable methods to realize it. Among these methods, flotation stands out as one of the most effective for enhancing phosphate ore, despite its inherent drawbacks of costliness and environmental impact stemming from chemical reagents.
This study endeavors to investigate the feasibility of employing electrostatic separation as an alternative method for enriching phosphate ore sourced from the Tebessa region in Algeria. Such exploration aims to offer insights into potentially more sustainable and economically viable approaches to ore enrichment in the region of Bir Elater Wilaya of Tebessa. Tests were carried out using different types of electrostatic separators at the Angouleme site of the PPRIME Institute: a multifunctional metal-belt-type separator, a free-fall plate-electrodes-type separator and an electrostatic separator with coaxial wire – cylinder electrode system. The experimental findings demonstrate significant promise, indicating that electrostatic separation enhanced the P2O5 content from 25 % to 29 % in an untreated phosphate ore sample. Simultaneously, it efficiently eliminated 82.80 % of MgO, achieving a P2O5 recovery rate more than 80 % and a yield of 70 %. Consequently, employing this method proves effective in reducing the MgO content of the ore to below than 1 %, aligning with industrial standards for commercial phosphate products. This underscores the viability of electrostatic separation as a viable and efficient technique in phosphate ore processing, offering substantial improvements in both quality and yield.
The choice of rational adjustment of the chemical composition of iron melted in an electric arc furnace on the basis of technological audit of serial films
Authors: Nikolaev Denis 
Published: May 2024

The object of research in the work is cast iron of the SCh20 grade according to GOST 1412-85 (DSTU EN 1561, EN-GJL-200), which is melted in an electric arc furnace. In this work, the parameters of serial smeltings of cast iron used for machine-building castings were determined, which were used to select the content of elements of the chemical composition.
The existing problem is that the impossibility of taking into account many factors influencing the formation of the chemical composition of cast iron during smelting leads to deviations of the chemical composition from the requirements regulated by the technical conditions. The main reason for this is the uncontrollability of the chemical composition of the charge materials and the difficulty of accurately determining the soot of the elements during the smelting process. This can lead to the formation of a shortage of cast iron, or to excessive costs for smelting, associated with the need for additional technological operations and the use of additional materials to eliminate detected deviations of the composition from the requirements.
The procedure of technological audit of serial smeltings is proposed, the feature of which is a comprehensive assessment of the actual indicators of smelting. They include: mathematical expectations of the content of the elements of the chemical composition, estimates of their dispersions, root mean square deviations, systematic errors, scattering fields and deviations of the lower and upper limits of the content of each element from the lower and upper limits required by the technical conditions. The results of such an audit are the possibility of calculating corrective combinations of charge materials and ferroalloys, which eliminate inaccuracies in the calculation of the charge and the determination of the heat of the elements during the smelting process.
As a result of the audit of a sample of 31 serial smelters, it was established that the average content of the elements C, Mn, Si, Cr exceeds the average required by technical conditions. These deviations are: +0.04 % C, +0.06 % Mn, +0.038 % Si, +0.06 % Cr. To compensate for these deviations, the following combination of charge materials and ferroalloys, which are introduced into the melt before delivering the cast iron to the casting area, is proposed: 44 kg of steel scrap +88 kg of recycled iron.
The presented study will be useful for machine-building enterprises that have foundries in their structure, where iron is melted for the production of castings.