bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic Differences in Thyroid Cancers From Primary Sites Versus Distant Metastases in Individual Patients: A Clinical Perspective and Preliminary Report
Authors: Lin Yen‐Bo , Hu Hsiang‐Wei , Chung An‐Ko , Lu Jin‐Ying , Wu Wan‐Chen , Chiu I‐Hsuan , Chu I , Lin Chia‐Chi , Lee Jih‐Hsiang , Nien Feng‐Jung , Chen Kuen‐Yuan , Wu Ming‐Hsun , Chen Chun‐Nan , Wang Chun‐Wei , Kuo Ting‐Chun , Lin Chia‐Hung , Cheng Mei‐Fang , Chiu Wei‐Yih , Kuo Shuenn‐Wen , Hsih Wen‐Hui , Wang Chih‐Yuan , Yang Wei‐Shiung , Chen Pei‐Lung , Shih Shyang‐Rong 
Published: February 2025

ABSTRACTBackgroundDistant metastasis is a leading cause of thyroid cancer (TC)‐related deaths. Genetic profiling is typically limited to one sample per patient due to cost and sampling‐risk concerns. Differences between samples from thyroid and distant metastasis within individual patients are unclear.MethodsPatients with TC and distant metastasis were recruited for genetic analysis.ResultsUsing a TC‐specific NGS panel, 66 specimens from 29 patients were analyzed, identifying 16 mutations and 4 fusions, including two novel fusions (FGFR2–SHTN1 and RFTN1–BRAF). Genetic alterations differed between primary and metastatic sites in nine patients (31%), predominantly in additional oncogenic alterations (89%). More genetic alterations were found at the primary site in three patients and metastatic sites in four. Distinct mutations were found in two patients. A longer time interval between specimen acquisitions was significantly associated with genetic discrepancies (p = 0.032).ConclusionPatterns of genetic discrepancies between primary and metastatic TC vary, offering valuable insights for clinical practice.
Different Epidemiology of Invasive Pulmonary Aspergillosis in Acute Lymphoblastic Leukemia in Comparison With Acute Myeloid Leukemia: Results of a Prospective Multicentric Observational Study of the Rete Ematologica Lombarda
Authors: Cattaneo C. , Bernardi M. , Fracchiolla N. , Pagani C. , Gigli F. , Basilico C. , Masina L. , Borlenghi E. , Bruno A. , Gela G. , Rossi G. , Tucci A. , Bertoli D. , Lussana F. , Todisco E. 
Published: February 2025

ABSTRACTThe negative impact of invasive pulmonary aspergillosis (IPA) in acute myeloid leukemia (AML) is well known whereas its clinical relevance in acute lymphoid leukemia (ALL) is still unclear. We have carried out a prospective multicentric observational study within the Rete Ematologica Lombarda to describe the incidence of IPA in acute leukemia (AL) patients, focusing on differences between AML and ALL. Between 2018 and 2020, 207 AL patients (AML: 165, ALL: 42) were evaluated. During induction, proven/probable and possible IPA were diagnosed in 32/207 patients (15.4%), equally divided into proven/probable and possible (16 each, 7.7%). IPA diagnosis was made in 23/165 (13.9%) AML and in 9/42 (21.4%) ALL patients (p = 0.2374). Proven/probable IPA were more frequent in ALL than in AML (ALL: 7/42, 16.6% vs. AML: 9/165, 5.4%; p = 0.0235). OS was similar in patients with or without proven/probable IPA (not reached vs. 63 months, p = 0.588), while OS was significantly reduced in possible IPA (22 months vs. not reached, p = 0.0167). More than 15 days of neutropenia duration and lack of antimold prophylaxis were associated with IPA. Achieving complete remission was protective, whereas age over 60 years and, with a borderline significance, possible IPA were associated with risk of death. In conclusion, Ph‐negative ALL should be considered at the same high risk for IPA as AML. Antimold prophylaxis should be probably extended also to ALL.
“You Pretend to Pay Me; I Pretend to Work”: A Multi‐Level Exploration of Quiet Quitting in the Greek Context
Authors: Georgiadou Andri , Vezyridis Paraskevas , Glaveli Niki 
Published: February 2025

ABSTRACTThis study explores quiet quitting—a distinct form of workplace withdrawal—in the Greek context, adopting a multilevel approach to understand how cultural, institutional and individual factors shape this emerging phenomenon. Drawing upon relevant literature, we investigate the macro, meso‐organizational, and micro‐individual level factors that shape the emergence and persistence of quiet quitting. Through a qualitative, interview‐based methodology, we engage with a diverse sample of Greek Human Resource (HR) managers to capture their perceptions and lived experiences of the factors that contribute to quiet quitting. Our findings highlight the complex interplay between societal shifts, cultural norms, organizational practices, and individual coping mechanisms that give rise to and sustain quiet quitting behaviors. We propose a conceptual framework that situates quiet quitting within the unique socio‐cultural, economic, and institutional realities of the Greek context. This framework reveals how quiet quitting manifests as a dynamic process, initiated by psychological contract breaches and perpetuated through cycles of emotional exhaustion and identity rationalization. By providing a holistic understanding of the quiet quitting phenomenon, this study contributes to the advancement of contextualized Human Resource Management (HRM) research and offers valuable insights for practitioners navigating the challenges of the modern workplace.
The Impact of Say‐On‐Pay on Firm Efficiency in Anglo‐Saxon Economies—Do CEO Personal Traits and CG Mechanisms Matter?
Authors: Joura Essam , Gerged Ali Meftah , Xiao Qin , Ullah Subhan 
Published: February 2025

ABSTRACTIn this study, we explore how the personal traits of CEOs and corporate governance mechanisms moderate the link between say‐on‐pay (SOP) votes and various aspects of firm efficiency. Our sample consists of 1931 firms listed in four Anglo‐Saxon economies (i.e., USA, UK, Canada and Australia) during a period of notable regulatory changes. Our findings reveal a significant and positive impact of SOP votes on firm efficiency. This suggests that company executives recognise that lower efficiency leads to lower pay or even job loss. Interestingly, our analysis indicates that younger managers can contribute more to creating value and improving business performance compared with their older counterparts. However, the relationship between gender and firm efficiency remains inconclusive. Furthermore, our study highlights the limited involvement of the board of directors in driving firm efficiency. This could be attributed to inadequate monitoring, cooperation and communication among board members, particularly in the case of audit committees, which seem to have less skilled members. Alternatively, this lack of board engagement may be due to the influence of powerful managers within the company. This paper also offers practical implications to policymakers and practitioners and suggests avenues for future research that can build upon our evidence.
The Abbreviated Math Anxiety Scale (AMAS): Applicability and Utility in a Sample of Japanese Elementary School Children
Authors: Ikeda Yoshifumi , Kita Yosuke , Takagi Riko , Suzuki Kento , Mammarella Irene Cristina , Caviola Sara , Lanfranchi Silvia , Pulina Francesca , Giofrè David 
Published: February 2025

ABSTRACTMath anxiety negatively affects math performance and future career choices in math‐related fields. Various tools assess math anxiety, but the Abbreviated Math Anxiety Scale (AMAS) is noteworthy for its ease of administration and good psychometric properties. This study evaluates the AMAS's applicability and utility in a sample of approximately 170 Japanese elementary‐school children. Findings indicate that the Japanese version of the AMAS has very good internal consistency, good test–retest reliability and validity, both convergent and concurrent. Results from a multigroup analysis showed that the scale shows no gender bias, although girls scored higher on the AMAS despite similar performance to boys on a standardised math test. These findings highlight the AMAS's potential as a screening tool for math anxiety in young children.
Economic Inequality Brings About More Inaction Over Climate Change: The Role of Perception, Discussion, and Responsibility
Authors: Wang Changcheng , Chen Xi , Jiang Tianhe 
Published: February 2025

ABSTRACTEmerging studies on climate change inaction predominantly focused on exploring its psychological roots. To extend this line of research, the present study was conducted to investigate whether, how and when economic inequality relates to climate change inaction taking into account subjective and objective economic inequality simultaneously. Utilising two large independent samples (Study 1: N = 1, 066; Study 2: N = 518), our research demonstrated causal links between higher subjective and objective economic inequality and increased climate change inaction. In societies with greater economic inequality, climate change inaction was more prevalent compared to those with lower economic inequality. Notably, these relations were mediated by climate change perception and moderated by climate change discussion and responsibility attribution, respectively. The findings advance existing research by identifying economic inequality as a novel antecedent of climate change inaction and further elucidating the underlying process and boundary condition. Additionally, these insights provide practical guidance for inaction‐reduction in the context of climate change.
Acute myeloid leukemia with RAM immunophenotype: A report of three patients and comprehensive literature review
Authors: Parisi Xenia , Ghosh Anindita , Medeiros L. Jeffrey 
Published: February 2025

AbstractIntroductionThe RAM immunophenotype (IP) in acute myeloid leukemia (AML) is defined by blasts with bright CD56 and weak‐to‐negative CD45, HLA‐DR, and CD38 expression. A RAM IP predominantly presents in infants who have “standard‐risk disease” under current criteria but, when treated accordingly, have devastatingly high rates of minimal residual disease and relapse with lower 3‐year and overall survival rates. However, given the relative rarity of this phenotype, it is neither well‐defined nor readily diagnosed.MethodsWe reviewed the electronic medical records of our institution from 1990 to 2024 for cases of AML expressing bright CD56 on flow cytometry and identified three cases with a RAM IP. Further, we performed a thorough literature search and reviewed impactful studies on pediatric AML and case/series reports of patients with a RAM IP, leading to the identification of 38 more cases.ResultsA total of 41 patients were collected. These patients were toddler age (1–3 years) with an equal sex distribution and clinically presented with low circulating blasts and cytopenias. Blasts were typically French–American–British M0 or M7. Immunophenotypically, CD33 and CD117 showed positivity in >90% of cases, with CD19, CD34, CD41, and CD42b, frequently positive. Half of the cases were positive for CD7 and CD61. T‐cell/myeloid markers were rare, except for cytoplasmic CD3, seen in 1/3, apparently correlating with CBFAT2T3:GLIS1 fusions. Gains in chromosomes 21, 13, and 8 and CBFAT2T3::GLIS1 fusions were frequent.ConclusionAML with a RAM IP has a poor prognosis. This study offers a detailed characterization of the clinicopathologic patterns associated with this rare entity, which may help formulate the most appropriate diagnostic approach.
Human Induced Pluripotent Stem Cells: Directed Differentiation Methods and Applications in Brain Diseases
Authors: Wang Yu , Wang Ziping , Wang Le , Sun Yanping , Song Huijia , Cheng Xiaokun , He Xiaoliang , Gao Zibin , Sun Yongjun 
Published: February 2025

ABSTRACTHuman induced pluripotent stem cells (hiPSCs), similar to embryonic stem cells, are a class of pluripotent stem cells with the potential to differentiate into various kinds of cells. Because the application of hiPSCs obtained by reprogramming patients' somatic cells in the treatment of brain diseases bypasses the ethical constraints on the use of embryonic stem cells and mitigates immune rejection, hiPSCs have profound clinical application prospects. In this review, we first summarized the differentiation methods of hiPSCs into different kinds of neurons, and secondly discussed the application of hiPSCs in several brain disease models, so as to provide a reference for the future application of hiPSCs in the studies and treatment of brain diseases.
Pleistocene habitats for proboscideans from five sites in the Japanese archipelago: Insights from isotopic composition of tooth enamel and dentin collagen
Authors: Naito Yuichi I. 
Published: February 2025

ABSTRACTMegafauna became extinct during the late Quaternary, with climate changes and human activities the two main proposed extinction drivers. Palaeoloxodon naumanni (Naumann's elephant) and Mammuthus primigenius roamed the Japanese archipelago during the Pleistocene. In contrast to the increasing amount of chronological information regarding extinct elephants, stable isotopic composition of these animals is less well studied, despite its potential to reveal foraging ecologies and surrounding paleoenvironments. The isotopic compositions were measured for tooth enamel and dentin collagen of fifteen P. naumanni and five Mammuthus sp. specimens from Lake Nojiri in Honshu and four sites in Hokkaido, Japan. Statistical differences were observed between the carbon isotopic composition of tooth enamel of the Lake Nojiri elephants and those of the two elephant species in Hokkaido, suggesting more open grassland for the former. In Hokkaido, no overlap was observed in the isotopic compositions of the two species, suggesting a separation in foraging behaviors. The specimens had relatively low nitrogen isotopic composition for Late Pleistocene elephants possibly reflecting an environmental stress at the edge of their distributions. The large isotopic variations of Naumann's elephants suggest that their demise was not triggered by inflexibility in their feeding strategies.
Sodium hypochlorite in cleaning products: Effects on surfactant/oil/water formulations calculated from the hydrophilic–lipophilic difference model
Authors: Falk Nancy A. 
Published: February 2025

AbstractIn this short communication, the role of sodium hypochlorite as a salt in a surfactant‐oil–water system is explored through calculations of the hydrophilic–lipophilic difference model. The effect of hypochlorite salt on hydrophilic–lipophilic difference (HLD) is mathematically calculated for anionic (sodium linear alkylbenzene sulfonate, sodium lauryl sulfate, and sodium cocoate) and a zwitterionic surfactant (cocoamidopropyl betaine) having different surfactant parameters (sometimes referred to as characteristic curvatures). Model systems typical of hypochlorite cleaning products showed negative HLD values for lipid soils, but near zero for essential oil components and other low‐equivalent alkane carbon number oils.
Effective Knowledge Management and Organizational Performance: Influence on Effective Response of Hospitals to COVID‐19
Authors: Fonseca Gleison Lopes , da Anunciação Pedro Fernandes , Briones Peñalver Antonio Juan 
Published: February 2025

ABSTRACTThis study aims to analyze the influence of effective knowledge management and organizational performance on the effectiveness of hospitals' responses to COVID‐19. Knowledge management is considered a fundamental resource for achieving improvement in health organizations' performance. Supported by this theoretical lens, this paper analyzes the relationship between the effectiveness of responding to crises and organizational performance. Data were collected through research sent to physicians and nurses who worked in hospitals in Brazil and Portugal. We sent the survey using a professional social network, and we have received 248 valid responses. The PLS‐SEM analysis technique was used to test hypotheses. The results showed that there is a positive correlation between effective knowledge management and organizational performance with the effective response to COVID‐19. In addition, the results suggest the need to develop internal programs to increment knowledge transfers among their professionals. As practical implications, our research validates the relationships between effective knowledge management, organizational performance, and hospital response effectiveness, as well as the importance of effective knowledge management for pandemic management. As originality, this work provides hospitals and other healthcare organizations with a direction to manage key resources to improve their effectiveness response to new disease outbreaks.
Measuring osteotomy wedge angle is more important than measuring wedge height in open wedge osteotomies around the knee in preoperative planning
Authors: Watrinet Julius , Schlaich Johannes , Vieider Romed , Rupp Marco‐Christopher , Mehl Julian , Siebenlist Sebastian , Runer Armin 
Published: February 2025

AbstractPurposePreoperative planning for medial open wedge high tibial osteotomies (HTOs) and lateral open wedge distal femur osteotomies (DFOs) commonly uses wedge height to guide accurate correction. However, it is unclear if this parameter is influenced by intraoperative variations in osteotomy entry point or length. This study hypothesized that wedge angle remains constant during planning, while wedge height varies depending on hinge or entry points.MethodsWhole leg radiographs of 40 patients who underwent HTO or DFO (2018–2024) were analysed using digital planning software. For each HTO and DFO case, 27 and 21 osteotomy variants were created, respectively, by altering entry and hinge points, resulting in 960 simulations. Wedge angle, wedge height and osteotomy depth were measured for each variant. Correlations and regression analyses assessed the relationships among these variables, and a mathematical formula was developed to predict wedge height from wedge angle and osteotomy depth.ResultsWedge angle remained consistent across variants (mean deviation: 0.1 ± 0.1°), while wedge height showed variability (mean deviation: 0.7 ± 0.5 mm) influenced by entry and hinge points. Significant correlations were found between wedge height and opening angle (R = 0.83, p < 0.001) and osteotomy depth (R = 0.60, p < 0.001). Predicted wedge height closely matched actual values (R = 0.998, p < 0.001), with minimal error (−0.01 ± 0.1°).ConclusionThis study highlights that relying solely on wedge height for osteotomy planning in HTO and DFO is insufficient due to variations in entry and hinge points. The hinge angle proved to be the most reliable parameter. Intraoperative osteotomy depth measurements can help adjust wedge height for accurate limb alignment when deviations occur.Level of EvidenceLevel V simulation study.
Redirection‐Manipulated Honeycomb Inclined Reflection System Enables Highly Efficient AlGaN‐Based Deep‐Ultraviolet Light‐Emitting Diodes
Authors: Liao Zhefu , Lv Zhenxing , Tang Bin , Sun Ke , Jiang Jingjing , Qi Shengli , Liu Sheng , Zhou Shengjun 
Published: February 2025

AbstractAlGaN‐based deep‐ultraviolet light‐emitting diodes (DUV LEDs) are considered promising and efficient solid‐state DUV light sources. However, extracting photons directly from high‐Al‐content AlGaN multiple quantum wells active region where the ratio of transverse magnetic (TM)/transverse electric (TE) polarization emission increases has long been challenging due to the total internal reflection phenomenon and re‐absorption effect, leading to the low efficiency of DUV LEDs. Herein, a redirection‐manipulated honeycomb inclined reflection system (HIRS) is demonstrated aimed at efficiently extracting TM‐ and TE‐polarized light from DUV LEDs, and systematically analyze the influence of the HIRS configurations on the resulting redirection effect. Crucially, the investigation reveals the effective range of the HIRS redirection effect, prompting the proposal of a pixelation strategy applicable to generalized AlGaN‐based DUV LEDs. This strategy is validated through the experimental fabrication of pixelated DUV LEDs integrated with HIRS. Compared to their non‐pixelated, non‐HIRS counterparts, these pixelated DUV LEDs integrated with HIRS achieve a light output power enhancement factor of up to 1.95, surpassing all previously reported pixelated DUV LEDs. Furthermore, the double‐side‐coated sapphire is introduced as a package plate to improve reliability and optical performance and develop a miniaturized sterilization module for effective water purification. This work not only provides guidance for high‐power AlGaN‐based DUV LEDs design and manufacture but also advances the development of efficient solutions for water purification.
Lag‐Compensated Hyperfine Terahertz Dual‐Comb Interferometer beyond Intrinsic Resolution and Sensitivity
Authors: Ma Liang , Fan Fei , Feng Jixin , Shen Peng , Yin Hang , Ji Yunyun , Wang Xianghui , Chang Shengjiang 
Published: February 2025

AbstractOptical coherence with high precision and sensitivity holds achievements in communication, metrology, and sensing. The optical vernier effect generated by the dual‐comb interference highlights coherence technology to heighten accuracy and sensitivity, particularly in the visible and infrared bands. However, the maturity in the frequency domain of the optical coherence may overshadow its attributes in the time domain, which are limited to enhancing comprehensive performance. This work provides a lag compensation technology in the time domain that enables hyperfine interference spectrum and vernier ultra‐resolution, verified by a cascading terahertz dual‐comb interferometer. This strategy proves a 71.4 times improvement in the vernier resolution beyond the intrinsic resolution, reaching the Nyquist sampling limit without necessitating unique optical materials or compromising device geometry. Furthermore, a universal Lag‐Interference‐Sensitivity correlation is established to guide an ultra‐sensitivity of 1.4 × 104 GHz·RIU−1 within the 0.2–1 THz range, defying two orders of magnitude compared to the existing reports. Finally, the application in biochemical sensing, reaching a sensitivity of 2.63 GHz·mm2·ng−1 and an accuracy of 0.59 ng·mm−2, outperforming current reports and stimulating further exploration of ultra‐sensitive terahertz biochemical on‐chip sensors, is demonstrated. This validation proves an appealing scheme for precision metrology and high‐resolution vernier sensing.
Sesquilinear forms as eigenvectors in quasi *‐algebras, with an application to ladder elements
Authors: Bagarello Fabio , Inoue Hiroshi , Triolo Salvatore 
Published: February 2025

AbstractWe consider a particular class of sesquilinear forms on a Banach quasi *‐algebra that we call eigenstates of an element , and we deduce some of their properties. We further apply our definition to a family of ladder elements, that is, elements of obeying certain commutation relations physically motivated, and we discuss several results, including orthogonality and biorthogonality of the forms, via Gelfand–Naimark–Segal (GNS) representation.