bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of High Bolus Dose Tirofiban on the Inflammatory Response Following Percutaneous Coronary Intervention
Authors: Azar Rabih R. , Badaoui Georges , Sarkis Antoine , Kassab Roland , Salamé Elie , Aboujaoudé Simon , Hamdan Righab , Barakett Vanda , Germanos Mirna 
Published: October 2009

AbstractBackgroundTirofiban at the bolus dose of 10 µg/kg does not suppress the inflammatory response following percutaneous coronary intervention (PCI). This may be due to less than optimal inhibition of platelet aggregation. High bolus dose tirofiban (25 µg/kg) allows better inhibition of platelet aggregation but its anti‐inflammatory effect remains unknown.HypothesisHigh bolus dose tirofiban exhibits anti‐inflammatory activity.MethodsA total of 100 patients referred for PCI were randomized to receive high bolus dose tirofiban followed by a 24‐h infusion or a bolus and an infusion of saline. Patients with elevated troponin or with thrombus in the culprit lesion were excluded. Inflammatory markers were measured at baseline and at 24 h.ResultsLevels of soluble CD40 ligand (sCD40L) were not affected by PCI while those of interleukin‐6 (IL‐6) and of high sensitivity C‐reactive protein (hs‐CRP) significantly increased. Despite inhibiting platelet's aggregation by > 90%, tirofiban did not suppress the rise of IL‐6 and hs‐CRP. Median (interquartile range) elevation of IL‐6 was 0.6 pg/mL (−1.5–3.6) versus 0.4 pg/mL (−0.7–1.8) and that of hs‐CRP was 2.1 mg/L (0.7–5.2) versus 2.4 mg/L (1–4.7) in the tirofiban and the control groups, respectively (p = ns). However, in patients with diabetes mellitus, tirofiban significantly suppressed the rise of hs‐CRP by 65% (p = 0.01), but did not significantly affect the rise of IL‐6.ConclusionIn low‐risk patients undergoing PCI, tirofiban did not attenuate the rise of inflammatory markers. However, the significant effect in diabetics suggests that tirofiban may have anti‐inflammatory activity in higher risk patients. Copyright © 2009 Wiley Periodicals, Inc.
Percutaneous Coronary Intervention for Acute Myocardial Infarction in a Single Coronary Artery Anomaly
Authors: Shalganov Tchavdar N. 
Published: October 2009

AbstractWe report on a case of an adult male patient with previously unknown coronary anomaly and acute myocardial infarction in the territory of the left anterior descending artery (LAD). The coronary angiography showed a single coronary artery with intertruncal course, arising from the right coronary sinus, and thrombotic occlusion of the LAD. Successful transradial percutaneous coronary intervention was done with implantation of an intracoronary stent in the occluded artery. The postprocedural course was complicated by ventricular tachycardia, congestive heart failure, and mild transient renal failure. In conclusion, transradial percutaneous coronary intervention is safe and feasible in rare coronary artery anomalies even in an emergent setting. The finding of an anomalous coronary artery should not be a reason to decline performing coronary intervention. Copyright © 2009 Wiley Periodicals, Inc.
Statins as Anti‐Arrhythmics: A Systematic Review Part II: Effects on Risk of Ventricular Arrhythmias
Authors: Abuissa Hussam , O'Keefe James H. , Bybee Kevin A. 
Published: October 2009

AbstractBackgroundRecent studies have demonstrated that statins may possess anti‐arrhythmic properties in addition to their lipid‐lowering effects.MethodsStudies which reported the association of statins with the incidence of ventricular arrhythmias were identified through a systematic review of the published literature.ResultsStatins have been associated with a significant reductions in ventricular arrhythmia in cardiomyopathy patients with an implantable cardioverter defibrillator, although randomized trials have not been completed.ConclusionsPublished data suggests that statins may possess anti‐arrhythmic properties that reduce the propensity for ventricular arrhythmias. Most of this data is observational; more randomized, placebo‐controlled trials are needed. Copyright © 2009 Wiley Periodicals, Inc.
Serial Analyses of C‐Reactive Protein and Myeloperoxidase in Acute Coronary Syndrome
Authors: Borges Flávia K. , Borges Fernando K. , Stella Steffan F. , Souza Juliana F. , Wendland Andréa E. , Werres Junior Luis Carlos , Ribeiro Jorge P. , Polanczyk Carísi A. 
Published: October 2009

AbstractBackgroundC‐reactive protein (CRP) and myeloperoxidase (MPO) are involved in the pathogenesis of atherosclerosis, mainly during periods of instabilization. This study aims to test the hypothesis that patients with acute coronary syndrome (ACS) maintain a persistent inflammatory state, and that this is associated with long‐term mortality.HypothesisWe hypothesized that serum C‐reactive protein and myeloperoxidase collected at the index event and later, could add to the prognostic information in patients with ACS.MethodsIn a prospective cohort of 115 consecutive patients with ACS, myeloperoxidase and C‐reactive protein were measured at admission and 2 y later. Patients were followed‐up for the occurrence of cardiac death and other major cardiac events.ResultsLevels of CRP decreased from 26 ± 34 mg/L in the acute phase to 6 ± 8 mg/L in the chronic phase (p < 0.001), and MPO levels decreased from 86 ± 43 pM to 27 ± 32 pM (p < 0.001). After 29 ± 12 mo, 27% patients died, 39% had new episode of ACS, and 30% underwent revascularization procedures. Initial CRP levels above 10 mg/L were associated with higher long‐term mortality (hazard ratio [HR]: 2.43; 95% confidence interval [CI]: 0.98 to 6.07; p = 0.048). MPO levels were not associated with death or other major events.ConclusionsChanges over time or absolute values in the chronic phase of both markers were not associated with clinical outcomes. CRP levels, but not MPO levels, in the index event were predictive of long‐term cardiovascular mortality. Copyright © 2009 Wiley Periodicals, Inc.
Usefulness of Brain Natriuretic Peptide Level at Implant in Predicting Mortality in Patients with Advanced But Stable Heart Failure Receiving Cardiac Resynchronization Therapy
Authors: El‐Saed Aiman , Voigt Andrew , Shalaby Alaa 
Published: October 2009

AbstractBackgroundBrain natriuretic peptide (BNP) level has emerged as a predictor of death and hospital readmission in patients with heart failure (HF). The value of baseline BNP assessment in advanced HF patients receiving cardiac resynchronization defibrillator therapy (CRT‐D) has not been firmly established.HypothesisWe hypothesized that a baseline BNP level would predict all cause mortality and HF hospitalization in HF patients receiving cardiac resynchronization therapy.MethodsA retrospective chart review of all patients having BNP assessment prior to implantation of a CRT‐D for standard indications during 2004 and 2005 was conducted at the Veterans Affairs Pittsburgh Healthcare System. The primary endpoint was all‐cause mortality and the secondary endpoint was HF‐related hospitalization. We used findings from the receiver operating characteristic (ROC) curve to define low (<492 pg/mL) and high (≥492 pg/mL) BNP groups.ResultsOut of 173 CRT‐D recipients, 115 patients (mean age 67.0 ± 10.7 years, New York Heart Association [NYHA] class 2.9 ± 0.3, left ventricular ejection fraction [LVEF] 22.5% ± 9.6%, QRS 148.3 ± 30.4 ms) had preimplantation BNP measured (mean 559 ± 761 pg/mL and median 315 pg/mL). During a mean follow‐up time of 17.5 ± 6.5 mo, 27 deaths (23.5%) and 31 HF hospitalizations (27.0%) were recorded. Compared to those with low BNP (n = 74), those of high BNP (n = 41) were older, had lower LVEF, higher creatinine levels, suffered more deaths, and HF hospitalizations. In multivariate regression models, higher BNP remained a significant predictor of both the primary endpoint (hazard ratio [HR]: 2.89, 95% confidence interval [CI] 1.06–7.88, p = 0.038) and secondary endpoint (HR: 4.23, 95% CI: 1.68–10.60, p = 0.002).ConclusionsBaseline BNP independently predicted mortality and HF hospitalization in a predominantly older white male population of advanced HF patients receiving CRT‐D. Elevated BNP levels may identify a vulnerable HF population with a particularly poor prognosis despite CRT‐D. Copyright © 2009 Wiley Periodicals, Inc.
Transcatheter Closure of Patent Ductus Arteriosus: Experience with a New Device
Authors: Aldo Agnetti , Nicola Carano , Bertrand Tchana , Valentina Allegri , Antonio Saracino , Umberto Squarcia , Donald J Hagler 
Published: October 2009

AbstractTranscatheter closure is the preferred method of treatment of patent ductus arteriosus (PDA). Detachable coils are widely used to close small ducts, while the Amplatzer duct occluder (ADO) is generally employed for moderate or large ducts. Recently a new device, the Amplatzer duct occluder II (ADO II), a nitinol flexible mesh, with a symmetrical design to provide high conformability for treatment of all types of PDA, has received the European Community mark approval. We report on one of the first experience, four cases (1 male, 3 female, age ranging from six months to seven years old) with different type and size of PDA treated with the new device. The use of this new Amplatzer duct occluder in our experience has the advantage of ease and safety of placement, conformability, stability, low profile catheters, adaptability for long ducts as in type E. Copyright © 2009 Wiley Periodicals, Inc.
A Practical Total Synthesis of the Microbial Alkaline Proteinase Inhibitor (MAPI)
Authors: Haebich Dieter , Hillisch Alexander , El Sheikh Sherif 
Published: October 2009

AbstractDiverse serine and cysteine proteases as well as alkaline proteinases and elastases play a crucial role in numerous biological processes. Natural peptide aldehydes such as the “microbial alkaline proteinase inhibitor” (MAPI, 1) are valuable tools to characterize novel enzymes and to study their function in nature. Within a drug discovery program we wanted to design and explore non‐natural MAPI congeners with novel biological profiles. To that end we devised a simple, practical, and scalable synthesis of MAPI 1 from readily available amino acid building blocks. The modular nature of our approach allows convenient structural modification of the MAPI backbone.
Quantitative Reflection Interference Contrast Microscopy (RICM) in Soft Matter and Cell Adhesion
Authors: Limozin Laurent , Sengupta Kheya 
Published: October 2009

AbstractAdhesion can be quantified by measuring the distance between the interacting surfaces. Reflection interference contrast microscopy (RICM), with its ability to measure inter‐surface distances under water with nanometric precision and milliseconds time resolution, is ideally suited to studying the dynamics of adhesion in soft systems. Recent technical developments, which include innovative image analysis and the use of multi‐coloured illumination, have led to renewed interest in this technique. Unambiguous quantitative measurements have been achieved for colloidal beads and model membranes, thus revealing new insights and applications. Quantification of data from cells shows exciting prospects. Herein, we review the basic principles and recent developments of RICM applied to studies of dynamical adhesion processes in soft matter and cell biology and provide practical hints to potential users.
Early response to family‐based treatment for adolescent anorexia nervosa
Authors: Doyle Peter M. , Le Grange Daniel , Loeb Katharine , Doyle Angela Celio , Crosby Ross D. 
Published: October 2009

AbstractObjective:The purpose of this study was to determine if early weight gain predicted remission at the end of treatment in a clinic sample of adolescents with anorexia nervosa (AN).Method:Sixty five adolescents with AN (mean age = 14.9 years, SD = 2.1), from two sites (Chicago n = 45; Columbia n = 20) received a course of manualized family‐based treatment (FBT). Response to treatment was assessed using percent ideal body weight (IBW) with remission defined as having achieved ≥95% IBW at end of treatment (Session 20).Results:Receiver operating characteristic analyses showed that a gain of at least 2.88% in ideal body weight by Session 4 best predicted remission at end of treatment (AUC = 0.674; p = 0.024).Discussion:Results suggest that adolescents with AN, receiving FBT, who do not show early weight gain are unlikely to remit at end of treatment. © 2009 by Wiley Periodicals, Inc. (Int J Eat Disord 2010;)
Role of Water and Solvent in the Formation of Three Mononuclear Copper(II) Crystals: A New Type of Hydrate Isomerism in Coordination Chemistry
Authors: Hazra Susanta , Koner Rajesh , Nayak Malabika , Sparkes Hazel A. , Howard Judith A. K. , Dutta Supriya , Mohanta Sasankasekhar 
Published: October 2009

AbstractRefluxing of the red compound [CuIIL1blabla(H2O)] (1) in acetone forms two new species: green [CuIIL1(H2O)] (2) and brown [CuIIL1] (3) [H2L1 = N,N′‐ethylenebis(3‐ethoxysalicylaldimine)]. Whereas both 1 and 2 are converted into 3 upon heating, 3 is converted back into 1 when exposed to air. The structures of all three compounds were determined crystallographically, from which the interesting hydrate isomerism of 1 and 2 are identified; in 1 a water molecule is encapsulated into the O4 section of the ligand through bifurcated hydrogen bonding, whereas in 2 a water molecule coordinates directly to the metal centre. Despite the metal ion binding to the ligand in the same manner in all three cases, the formation of different mononuclear complexes resulting from the presence or absence of water and its coordination or encapsulation is an interesting observation. Thermogravimetric analyses of compounds 1 and 2 showed that the encapsulated water in the former compound is removed at slightly lower temperature than that of the coordinated water molecule, as expected. Although three crystals 1, 2 and 3 were isolated, the composition of species in solution is probably the same as evidenced by 1H NMR spectroscopy. Therefore, the formation of three crystals and the hydrate isomerism described in this investigation are solid‐state phenomena.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Syntheses, Crystal Structures, Thermal Properties and Spectroscopic Characterization of Complex Chloridotitanates(IV) with Ionic Liquids
Authors: Leye Johann‐Christian , Gjikaj Mimoza , Adam Arnold 
Published: October 2009

AbstractBy the reaction of [EMIm]Cl with TiCl4 in two different solvents the three new chloridotitanate complexes [EMIm]2[TiCl6] (I), [EMIm][TiCl5MeCN] (II) and [EMIm]4[TiCl6][Ti2Cl10] (III) were obtained. The crystal structures and the unit cell parameters were determined. The Raman spectra were measured to investigate the distorted octahedral symmetry of the corresponding anionic unit. Differential scanning calorimetry and thermal gravimetric measurements were accomplished to characterize the thermal stability. In addition, NMR and IR spectroscopy and elemental analysis were made to complete the characterization.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
A Chlorine‐Centered Cluster of Composition [(Me3Si)2NC(NCy)2SmCl2]5(thf)2 and a Comparison with the Heavier Ytterbium Congener [(Me3Si)2NC(NCy)2YbCl2]2(LiCl)2(thf)4
Authors: Zhang Zhensheng , Roesky Herbert W. , Schulz Thomas , Stalke Dietmar , Döring Alexander 
Published: October 2009

AbstractA unique (guanidinato)samarium dichloride cluster [(Me3Si)2NC(NCy)2SmCl2]5(thf)2 was synthesized from anhydrous SmCl3 and (Me3Si)2NC(NCy)2Li in thf/toluene solution. This cluster exhibits a novel structure containing a chlorine atom with four coordinated samarium atoms. The X‐ray crystal structure was investigated and compared with that of the heavier ytterbium congener [(Me3Si)2NC(NCy)2YbCl2]2(LiCl)2(thf)4. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Ground State Electronic Interactions in Macrocyclic Fullerene Bis‐Adducts Functionalized with Bridging Conjugated Oligomers
Authors: Figueira‐Duarte Teresa M. , Lloveras Vega , Vidal‐Gancedo José , Delavaux‐Nicot Béatrice , Duhayon Carine , Veciana Jaume , Rovira Concepció , Nierengarten Jean‐François 
Published: October 2009

AbstractMacrocyclic C60‐(π‐conjugated oligomer) dyads have been prepared from the corresponding bis‐malonates by a macrocyclization reaction on the C60 sphere. In both multicomponent systems, the fullerene moiety and the π‐conjugated oligomer subunit are at the van der Waals contact due to the cyclic structure. Interestingly, the characteristic π‐π* electronic transition band of the conjugated system is significantly red‐shifted in both dyads with respect to the corresponding model compounds lacking the fullerene unit (Δλmax = 24 to 34 nm). Whereas the absorption properties are dramatically affected by the intramolecular electronic interactions between the conjugated bridging system and the accepting C60 spheroid, cyclic voltammetry revealed only small changes in their redox potentials. However, these intramolecular interactions have a significant influence on the electronic coupling of the two terminal aniline redox units of the conjugated system in the dyads. Actually, when compared to the corresponding model compound 14·+, delocalization of the positive charge in the mixed‐valence species derived from the dyad 1 is more difficult due to the π‐π interactions of the conjugated system with the electron‐withdrawing fullerene group. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Short Regioselective Chemoenzymatic Synthesis and Biological Evaluation of 1‐O‐Acyl‐2‐O‐(β‐D‐sulfoquinovopyranosyl)‐sn‐glycerols
Authors: Dangate Milind , Franchini Laura , Ronchetti Fiamma , Arai Takanari , Iida Akira , Tokuda Harukuni , Colombo Diego 
Published: October 2009

AbstractA convenient chemoenzymatic synthesis of a new class of non‐natural sulfo‐glycolipids – 2‐O‐(β‐D‐sulfoquinovosyl)‐monoacylglycerols (2‐O‐β‐D‐SQMG) – derived from 2‐O‐(β‐D‐glucopyranosyl)glycerol and carrying acyl chains ofvarious lengths at the 1‐position of the sn‐glycerol moiety, was performed with the aid of a key step involving regioselective lipase‐catalyzed acylation of 2‐O‐(6‐deoxy‐6‐tosyl‐β‐D‐glucopyranosyl)‐sn‐glycerol (4) at its 1‐position, reported here for the first time. Elaboration of the sugar moiety through thioacetate substitution of the selectively inserted tosyl group with subsequent Oxone® oxidation in the presence of unprotected primary and secondary hydroxy groups efficiently afforded the target compounds, the hexanoyl, dodecanoyl, and octadecanoyl derivatives 1a–c, which were active when tested in the EBV‐EA in vitro assay for antitumor promoters. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Imaging the Origins of Coating Degradation and Blistering Caused by Electrolyte Immersion Assisted by SECM
Authors: Souto R. M. , González‐García Y. , González S. , Burstein G. T. 
Published: October 2009

AbstractA new method to image the origins of coating degradation and the nucleation and subsequent growth of blisters by using SECM in the feedback mode is proposed. The unique role of chloride ions towards coating performance has been established at a very early stage following immersion of the sample. We believe this to show the earlier stages of blistering in a coated metal system ever recorded. The method allowed for the first time to detect the nucleation and to monitor quantitatively the growth process of an individual blister, because it effectively advanced towards the microelectrode when scanned at constant height over the sample.
Electrochemical Oxidation and Detection of Morphine at Ordered Mesoporous Carbon Modified Glassy Carbon Electrodes
Authors: Bo Xiangjie , Xie Wenlin , Ndamanisha Jean Chrysostome , Bai Jing , Guo Liping 
Published: October 2009

AbstractIn this work, three ordered mesoporous carbons (OMCs) with different structural parameters were synthesized by a simple variation of the hydrothermal temperature of the silica templates (SBA‐15). X‐ray diffraction and nitrogen adsorption‐desorption results show these OMCs exhibit an ordered 2D hexagonal mesostructure with tunable pore diameter. OMC‐modified glassy carbon electrodes exhibit efficient electrocatalytic reactivity toward oxidation of morphine (MO). The amperometric detection of MO in pH 7.0 phosphate buffered saline at +0.39 V versus Ag/AgCl is the lowest potential reported to‐date. A linear range from 0.2 to 197.6 μM and a detection limit of 0.03 μM MO were obtained.
Photo‐polymerized lauryl methacrylate monolithic columns for CEC using lauroyl peroxide as initiator
Authors: Bernabé‐Zafón Virginia , Beneito‐Cambra Miriam , Simó‐Alfonso Ernesto F. , Ramis‐Ramos Guillermo , Herrero‐Martínez José Manuel 
Published: October 2009

AbstractLauryl methacrylate (LMA)‐ester based monolithic columns photo‐polymerized using lauroyl peroxide (LPO) as initiator were prepared, and their morphological and CEC properties were studied. The composition of the polymerization mixture (i.e. ratios of monomers/porogenic solvents, 1,4‐butanediol/1‐propanol and LMA/crosslinker) was optimized. The morphological and chromatographic properties of LMA columns were evaluated by means of SEM pictures and van Deemter plots of PAHs, respectively. The polymerization mixture selected as optimal provided a fast separation of a mixture of PAHs with excellent efficiencies (minimum plate heights of 8.9–11.1 μm). Satisfactory column‐to‐column (RSD<4.5%) and batch‐to‐batch reproducibilities (RSD<6.3%) were achieved. The LMA columns photo‐polymerized with LPO were compared with those prepared with AIBN. Using PAHs, alkylbenzenes and basic compounds for testing, the columns obtained with LPO gave the best compromise between efficiency, resolution and analysis time.
Forecasting business failure in China using case‐based reasoning with hybrid case respresentation
Authors: Li Hui , Sun Jie 
Published: October 2009

AbstractCase‐based reasoning (CBR) is a very effective and easily understandable method for solving real‐world problems. Business failure prediction (BFP) is a forecasting tool that helps people make more precise decisions. CBR‐based BFP is a hot topic in today's global financial crisis. Case representation is critical when forecasting business failure with CBR. This research describes a pioneer investigation on hybrid case representation by employing principal component analysis (PCA), a feature extraction method, along with stepwise multivariate discriminant analysis (MDA), a feature selection approach. In this process, sample cases are represented with all available financial ratios, i.e., features. Next, the stepwise MDA is used to select optimal features to produce a reduced‐case representation. Finally, PCA is employed to extract the final information representing the sample cases. All data signified by hybrid case representation are recorded in a case library, and the k‐nearest‐neighbor algorithm is used to make the forecasting. Thus we constructed a hybrid CBR (HCBR) by integrating hybrid case representation into the forecasting tool. We empirically tested the performance of HCBR with data collected for short‐term BFP of Chinese listed companies. Empirical results indicated that HCBR can produce more promising prediction performance than MDA, logistic regression, classical CBR, and support vector machine. Copyright © 2009 John Wiley & Sons, Ltd.