bluuebunny/crossref_metadata_2025_split huggingface dataset:
The outcome of relapsed childhood acute lymphoblastic leukemia after allogeneic hematopoietic stem‐cell transplantations: A single‐center experience
Authors: Aygüneş Utku , Karagün Barbaros Şahin , Şaşmaz Ilgen , Antmen Ali Bülent 
Published: May 2024

AbstractIn children with high‐risk childhood acute leukemia who undergo allogeneic hematopoietic stem‐cell transplantation (allo‐HSCT), relapse is still the leading cause of treatment failure. The prognosis is poor, yet prospective studies have only limited data on risk factors and outcomes. We aimed to understand the outcomes and prognostic factors for patients with acute lymphoblastic leukemia (ALL) who relapsed following allo‐HSCT. We analyzed retrospectively 46 children with childhood acute lymphoblastic leukemia who had relapsed after receiving their first alloHSCT. All these patients received salvage chemotherapy which consisted of fludarabine, cytarabine, and idarubicin before performing a second alloHSCT. The median follow‐up of the 46 patients after the first transplantation was 366 days. The median time from first allo‐HSCT to relapse was 278.4 ± 238.4 days. Forty‐six patients received salvage chemotherapy before the second alloHSCT, and CR was achieved in 32 of 46 patients. However, only 17 (37%) of 46 patients received a second allo‐HSCT, and 15 of 46 patients died from disease progression, infections, and bleeding. Twelve patients are still alive after the second allo‐HSCT. Two‐year overall survival (OS) was 38.9%. Local therapy was given to 10 (21.8%) patients, either as part of systemic therapy or alone. In multivariate analyses, the time of relapse and curative salvage therapy with a second allo‐HSCT were identified as significant prognostic factors for OS. Children with leukemia who had relapsed after the first allo‐HSCT received salvage chemotherapy. Our statistical analysis showed that the second HSCT could be beneficial for outcomes if patients relapsed beyond 180 days of the first allo‐HSCT.
Diagnosis of methamphetamine‐induced psychotic disorder: Findings of an expert consensus panel
Authors: Camfield Katherine , Reedy Anthony , Wolf Chelsea , Al‐Tayyib Alia , Rinehart Deborah , Simpson Scott A. ,   for the BEAT Meth MIPD Expert Panel
Published: May 2024

AbstractAimWe define criteria for methamphetamine‐induced psychotic disorder (MIPD) to aid in accurate and reliable diagnosis.MethodAn expert panel was recruited and engaged in an iterative consensus process. A literature search supported this work. The a priori level for consensus was considered ≥80% of voting panellists.ResultsThe final expert panel included 22 physicians from different backgrounds and practice environments. The panel produced two consensus diagnoses: (1) acute MIPD and (2) persisting MIPD, which is further separated into subacute and chronic timeframes. Although certain characteristics differentiate methamphetamine‐induced psychosis shortly after use, identification of persisting MIPD depends largely on a history of symptom onset. All respondents voted in the final round, and both criteria were fully endorsed by 91% (20/22) of respondents. Panellists further recommended next steps in validation and research on this topic.ConclusionThese diagnostic criteria aid clinicians in differentiating methamphetamine‐induced psychotic symptoms from psychosis because of other psychiatric disorders and can guide future studies. Future research might examine these criteria's prognostic significance, interrater reliability and acceptability including among persons in recovery. This work is a necessary and vital step in advancing the science of methamphetamine addiction treatment.
Just a story? Leadership, lived experience and integrated care
Authors: Miller Robin , Ehrenberg Nieves , Jackson Caroline , Stein Viktoria , Van der Vlegel‐Brouwer Wilma , Wojtak Anne 
Published: May 2024

AbstractBackgroundIntegrated care is based around values of involvement and shared decision‐making, but these are not often reflected within planning and implementation. Barriers include continued emphasis on professional and managerial perspectives, skills gaps on how best to engage people and communities and insufficient investment in involvement infrastructure. Despite such challenges, people with lived experience have still led changes in policy and services.DesignQualitative study involving 25 participants with lived experience from 12 countries. Participants shared their background stories and engaged in semistructured interviews relating to leadership identity, experience of influencing and personal learning. Transcripts were analysed through a framework approach informed by narrative principles.ResultsParticipants were motivated by their own experiences and a wish to improve care for future individuals and communities. Sharing their story was often the entry point for such influencing. Participants gained skills and confidence in story telling despite a lack of support and development. Many felt comfortable being described as a leader while others rejected this identity and preferred a different title. No common alternative term to leader was identified. Influencing services required considerable personal cost but also led to new networks, skills development and satisfaction when change was achieved.DiscussionLeadership within integrated care is often awarded to those with structural power related to management or clinical seniority. People with lived experience are though uniquely placed to identify what needs to change and can develop inspiring visions based around their personal stories. Claiming identity as leader can be challenging due to traditional notions of who is eligible to lead and unwillingness by professionals and managers to grant such identity.ConclusionsPeople with lived experience should be recognised as leaders of integrated care and have access to developmental opportunities and practical support to strengthen their skills, including that of storytelling.Patient and Public ContributionThe research was instigated on the request of a community advisory board of people with lived experience who shaped its design, contributed to the analysis and informed the conclusions and implications.
Ablation behavior of Csf/SiC‐BN composites with polyborosilazane as sintering aids: High‐temperature damage mechanism
Authors: Li Daxin , Wang Yan , Dou Wenhao , Niu Zibo , Cai Delong , Yang Zhihua , Jia Dechang , Zhou Yu 
Published: May 2024

AbstractMicrostructural evolution and high‐temperature ablative damage mechanism of Csf/SiC‐BN composites with and without polyborosilazane (PBSZ) as sintering aids that can convert to polymer‐derived SiBCN ceramics (PDCs‐SiBCN) by cross‐linking and pyrolysis during sintering were studied. The density of Csf/SiC‐BN composites increases from 2.17 to 2.25 g/cm3 with 10 wt.% sintering aids because PBSZ promotes rearrangement and redistribution of raw materials by pyrolysis during the sintering process. With the increase of carbon fiber content, ablation performance (mass ablation rate: 15.25 mg/s; linear ablation rate: 0.100 mm/s) negligibly decreases, compared to counterparts with lower fiber content (mass ablation rate: 16.53 mg/s; linear ablation rate: 0.072 mm/s) because the presence of PDCs‐SiBCN partially compensates for the detrimental effect of carbon fibers on ablation performance. Csf/SiC‐BN composites with and without PBSZ show similar phase composition mainly containing quartz, amorphous SiO2, and matrix crystallization products and morphology after ablation because of similar phase composition before ablation. The ablation mechanism is oxidative corrosion and mechanical scouring and stripping.
Predicting the quencher concentration of Er3+‐doped borate glasses via neighboring glassy compounds
Authors: Lun Zhenjie , Wu Minbo , Zuo Di , Xu Shanhui , Chen Dongdan , Yang Zhongmin 
Published: May 2024

AbstractThe quencher concentration (cmax) of rare‐earth (RE3+) doped laser glass plays a pivotal role in achieving high laser gain. However, it is still challenging to quantitatively calculate and predict the cmax of RE3+ ions in laser glass. Here, we propose and demonstrate a robust method in predicting the local environment and the cmax of RE3+ in laser glasses from their neighboring glassy compounds (NGCs). Specifically, the NGCs method capably predicts the local environment of Er3+ ions in borate glasses (B2O3–BaO binary and B2O3–BaO–Li2O ternary glasses). Moreover, the NGCs’ method accurately predicts the cmax of Er2O3 in borate glasses with an error of less than 5% compared to the experimental result, showing the promising prediction capability for the cmax of RE3+ ions. Based on the NGCs method, the cmax database of Er3+‐doped borate glasses is established for efficiently tailoring compositions with desired optical properties. This study offers a rapid and low‐cost route to design novel laser glasses.
Drugs targeting CTGF in the treatment of pulmonary fibrosis
Authors: Qiu Yudan , Que Yueyue , Ding Zheyu , Zhang Shanshan , Wei Rong , Xia Jianing , Lin Yingying 
Published: May 2024

AbstractPulmonary fibrosis represents the final alteration seen in a wide variety of lung disorders characterized by increased fibroblast activity and the accumulation of substantial amounts of extracellular matrix, along with inflammatory damage and the breakdown of tissue architecture. This condition is marked by a significant mortality rate and a lack of effective treatments. The depositing of an excessive quantity of extracellular matrix protein follows the damage to lung capillaries and alveolar epithelial cells, leading to pulmonary fibrosis and irreversible damage to lung function. It has been proposed that the connective tissue growth factor (CTGF) plays a critical role in the advancement of pulmonary fibrosis by enhancing the accumulation of the extracellular matrix and exacerbating fibrosis. In this context, the significance of CTGF in pulmonary fibrosis is examined, and a summary of the development of drugs targeting CTGF for the treatment of pulmonary fibrosis is provided.
We need to talk about the role of zooplankton in marine food webs
Authors: Thorpe Robert B. 
Published: May 2024

AbstractZooplankton are the key intermediary between primary production and the fish community and a cornerstone of marine food webs, but they are often poorly represented in models that tend to focus on fish, charismatic top predators, or ocean biogeochemistry. In this study, we use an intermediate complexity end‐to‐end food web model of the North Sea with explicit two‐way coupling of zooplankton to phytoplankton and higher trophic levels to ask whether this matters. We vary the metabolic rate of omnivorous zooplankton (OZ) as a proxy for uncertainties in our understanding and modeling of zooplankton form and function, and moving beyond previous studies we look at the impacts on the food web in concert with climate warming and fishing. We consider impacts on food web state and time to recover the relevant unfished state after fishing ceases. We also consider potential impacts on pelagic and demersal fishing fleets if we assume that they are constrained by the requirement to allow recovery to an unfished state within a certain period of time as a way of ensuring consistency with Good Environmental Status as required by EU and UK legislation. We find that all three aspects considered are highly sensitive to changes in the treatment of zooplankton, with impacts being larger than for warming of 2 or 4°C across most food web functional groups, particularly for apex predators. We call for a programme of research aimed at improving our understanding of zooplankton ecology and its relationship to the wider food web, and we recommend that improved representations of zooplankton are incorporated in future modeling studies as a priority.
Changes in the environmental impacts of the waste management system after implementing the waste‐sorting policy: A Beijing case study
Authors: Liu Tingting , Wang Peize , Zhang Qian , Cao Jing , Wu Yufeng 
Published: May 2024

AbstractQuantifying the environmental impacts of a household waste‐sorting policy on the household waste management system, including collection, transportation, and treatment, is the basis for evaluating the policy's effectiveness. Beijing, the capital of China, began to implement the mandatory domestic waste‐sorting policy in May 2020. In this study, we aimed to evaluate the environmental impacts of the household waste management system in Beijing before and after implementing the sorting policy using the life cycle assessment method. Implementing the policy at the waste collection stage reduced the environmental impacts by minimizing the number of garbage bins consumed through their removal and consolidation. At the transportation stage, implementing the policy increased the environmental impacts per unit of waste via transportation structure changes. However, the overall impact was reduced because more recyclable materials were separated after waste sorting. The environmental impacts were reduced after implementing the policy at the treatment stage mainly because of the change in waste composition and the decrease in the total volume of treatment. Global warming potential (GWP) was the main contributor to the environmental impacts. After waste sorting, the GWP of the collection, transportation, and treatment stages decreased by −19.96%, −24.36%, and −38.08%, respectively, resulting in a total GWP reduction of −37.90%. However, incineration and biochemical treatments may offer environmental benefits.
Divided we fall: Constructive dialoguing about our political differences within family therapy training
Authors: Laszloffy Tracey A. , Platt Jason J. 
Published: May 2024

AbstractWidespread political polarization throughout the United States is a threat to the time‐honored democratic tradition of utilizing civil discussion and respectful debate to express divergent views and strive for common ground. The political differences that divide us now are so deep and rife with toxic emotion that they threaten to undermine our social well‐being at both the micro and macro levels. While family therapists are trained to work with relational tensions and to help family members to constructively negotiate their differences, the severity of the hostility and resentment tied to divergent political orientations has made this work increasingly difficult to achieve. This article explores how family therapy training programs can help trainees deepen their capacity for constructive political dialoguing that includes learning how to effectively manage their reactivity to those whose values and views may be dramatically different from their own so that they can support clients in doing the same.
Knockdown of sulfotransferase 2B1 suppresses cell migration, invasion and promotes apoptosis in ovarian carcinoma cells via targeting annexin A9
Authors: Gao Haocheng , Xia Mengjuan , Ruan Heqiu 
Published: May 2024

AbstractBackgroundSulfotransferase family 2B member 1 (SULT2B1) has been reported to play oncogenic role in many types of cancers. Nevertheless, the role that SULT2B1 played in ovarian cancer (OC) and the hidden molecular mechanism is obscure.MethodsExpression of SULT2B1 in OC was analyzed by GEPIA database. qRT‐PCR and western blot (WB) was applied for the appraisement of SULT2B1 and Annexin A9 (ANXA9) in OC cell lines. The capabilities of cells to proliferate, migrate and invade were assessed with CCK‐8 assay, wound healing assay, along with transwell assay. Cell apoptotic level was estimated utilizing flow cytometry. WB was employed for the evaluation of migration‐ and apoptosis‐related proteins. Bioinformatic analysis and co‐immunoprecipitation were used to predict and verify the combination of SULT2B1 and ANXA9.ResultsThe data showed that SULT2B1 and ANXA9 were upregulated in OC cells. SULT2B1 depletion suppressed the proliferative, migrative, and invasive capabilities of SKOV3 cells but facilitated the cell apoptosis. SULT2B1‐regulated ANXA9 expression and were proved to bind to ANXA9. Additionally, ANXA9 deficiency exhibited the same impacts on cell migrative, invasive capability and apoptotic level as SULT2B1 silencing. Moreover, ANXA9 overexpression reversed the inhibitory impacts of SULT2B1 silencing on the proliferative, migrative, invasive, and apoptotic capabilities of SKOV3 cells.ConclusionIn summary, SULT2B1 silencing repressed OC progression by targeting ANXA9.
Environmental public hearings and intersectionality: women's voices from Gujarat, India
Authors: GILL GITANJALI NAIN , JOSHI FALGUNI 
Published: May 2024

AbstractThis article examines the application of the intersectionality framework to the Indian statutory institutional environmental public hearing (EPH) process that seeks to promote environmental justice. Intersectionality provides a framework to capture the processes of gender marginalization and exclusion. It critically demonstrates how the required gender participation in the regulatory EPH process is failing rural women in the state of Gujarat, India, thereby exacerbating discrimination and inequality. Building on the researchers’ mixed‐methods (quantitative and qualitative) data, the article creates an evidence‐based ‘fresh dossier’ reflecting the non‐existent or limited participatory involvement of women as valuable stakeholders in the EPH process. Drawing on the evidence of lived experiences creates spaces for women's voices that are excluded from the social system due to dominant powers and institutional structures. We argue that respecting the diversity of interests and identities of rural Gujarati women within the institutionalized public sphere would promote participation and recognition of their knowledge and role as crucial stakeholders.
A qualitative investigation of narratives of Black forgiveness through the lens of critical race theory
Authors: Perez Michael J. , Rivera Grace N. , Crist Jaren D. , Battle Jericka S. 
Published: May 2024

AbstractThrough a Critical Race Theory perspective, we investigated how racial ideology, in particular colorblind ideology, was present in Black forgiveness narratives for racial violence. We collected United States news articles from two high profile cases of Black forgiveness (N = 122), the shooting at the Emanuel African Methodist Episcopal Church and the killing of Botham Jean. We used a thematic analysis to address an overarching research question of: In what ways are these Black forgiveness narratives reflective of racial ideologies that may pressure or misrepresent Black forgiveness? Our results suggested that colorblind ideologies were present in representations of Black forgiveness. Colorblind representations of Black forgiveness ignored and diminished the racial context of the cases, reinforced false equivalencies through Christian messaging, perpetuated Black forgiveness as a palatable path to peace, and maintained a perception of White virtue and morality despite racial violence.
Effectiveness of peer‐delivered sleep health education and social support in increasing OSA evaluation among at‐risk blacks
Authors: Jean‐Louis Girardin , Jin P. , Moise R. , Blanc J. , Rogers A. , Bubu O. M. , Chung D. , Zizi F. , Seixas A. A. 
Published: May 2024

SummaryTo assess the effectiveness of culturally and linguistically tailored, peer‐delivered obstructive sleep apnea education and of social support to increase adherence to physician‐recommended obstructive sleep apnea evaluation among blacks. In a two‐arm randomised controlled trial, we ascertained the effectiveness of peer‐delivered obstructive sleep apnea education in increasing obstructive sleep apnea evaluation among 319 blacks at risk of obstructive sleep apnea (intervention = 159 and control = 160); their average age was 47 ± 12.9 years, and 41% were male. Obstructive sleep apnea risk was assessed with the Apnea Risk Evaluation System questionnaire, administered in community venues. Participants in the intervention arm received tailored obstructive sleep apnea education during a 6 month period; those in the control arm received standard sleep and healthy lifestyle information. Analysis focussed on the effectiveness of peer‐delivered obstructive sleep apnea education on adherence to obstructive sleep apnea evaluation, but also considered the role of psychosocial factors. The results showed no significant differences in baseline demographic and clinical measures when contrasting participants in the study arms. The adherence rates for home‐based obstructive sleep apnea evaluation in the intervention and control arms were 45.9% and 45.6%, respectively. Overall, participants in both study arms (adherers) who underwent obstructive sleep apnea evaluations were likely to experience a greater level of social support (8.2 ± 2.4 vs. 7.3 ± 2.4; p = 0.06). Moreover, adherers showed greater psychosocial scores (i.e., Dysfunctional Beliefs and Attitudes about Sleep scale, Apnea Beliefs Scale (ABS) (and Apnea Knowledge) compared with non‐adherers (6.0 ± 1.8 vs. 4.9 ± 2.2; p = 0.02; 77.0 ± 7.1 vs. 73.2 ± 7.4; p = 0.04, and 6.4 ± 3.1 vs. 7.6 ± 2.4; p = 0.06, respectively). The results of the present randomised controlled trial favoured a potential role of peer‐based social support and psychosocial factors, associated with obstructive sleep apnea adherence behaviour.
The imaginarium of self‐care: Speculative futures of hope for student mental health
Authors: Gordon Loa 
Published: May 2024

AbstractRecent ethnographies have investigated self‐care as a socially driven configuration of care. This analysis engages theorizing on the imagination to expose new social dimensions of self‐care in cases of mental health as embodied and communal. Based on fieldwork across Canadian universities and in conversation with students, campus wellness providers, and a group of psychiatric epidemiologists seeking to understand the mental health treatment choices of students, this article examines how these different subjects activate what I call an imaginarium of self‐care. Among young adults in Canada, mounting social ills that go therapeutically unaccounted for have relocated forms of self‐care into the imagination through play and world‐building in ways that challenge the distinction between material and speculative healing. Attending to the imaginative dimensions of self‐care makes coherent the ways that young people are grasping for hope in a world that—when embodied—resists recovery.