bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRIM56 Promotes White Adipose Tissue Browning to Attenuate Obesity by Degrading TLE3
Authors: Qin Haojie , Zhong Yi , Huang Jinhui , Miao Yanli , Du Meng , Huang Kai 
Published: February 2025

AbstractIn mammals, the activation of thermogenic adipocytes, such as beige and brown adipocytes, can significantly increase overall energy expenditure, offering a promising strategy to combat metabolic diseases. Despite its considerable potential, the regulatory mechanisms governing this activation remain largely elusive. This study bridges this gap by elucidating that tripartite motif 56 (TRIM56), an E3 ubiquitin ligase, is upregulated in response to cold stimuli, thereby promoting the recruitment of beige adipocytes. Notably, the overexpression of TRIM56 in adipocytes is shown to help mice maintain a core temperature under cold conditions, as well as confer protection against diet‐induced obesity. Mechanistically, TRIM56 facilitates the degradation of the transducin‐like enhancer protein 3 (TLE3) protein by promoting its K48‐linked ubiquitination, which subsequently triggers the activation of thermogenic genes in subcutaneousl white adipose tissue and improved the metabolic profiles. These findings unveil a novel function for TRIM56 in adipocyte browning, suggesting its potential as a therapeutic target for the treatment of metabolic disorders.
Patient‐Derived Bladder Cancer Organoids as a Valuable Tool for Understanding Tumor Biology and Developing Personalized Treatment
Authors: Zhao Hongda , Lin Na , Ho Vincy Wing Sze , Liu Kang , Chen Xuan , Wu Hongwei , Chiu Peter Ka‐Fung , Huang Linda , Dantes Zahra , Wong Ka‐Leung , Chau Ho‐Fai , Ko Ivan Ching‐Ho , Wong Chris Ho‐Ming , Leung David Ka‐Wai , Yuen Steffi Kar‐Kei , Wu Dinglan , Ding Xiaofan , Ng Chi Fai , Teoh Jeremy Yuen‐Chun 
Published: February 2025

AbstractBladder cancer (BC) is a heterogeneous disease with high recurrence rates and variable treatment responses. To address these clinical challenges, the world's first bladder cancer patient‐derived organoids (PDOs) biobank is established based on an Asian population. Thirty‐six BC‐PDOs are generated from 56 patients and demonstrated that the BC‐PDOs can replicate the histological and genomic features of parental tumors. Drug screening tests are conducted with a broad spectrum of conventional chemotherapeutic and targeted therapy drugs and identified differential drug sensitivities among the BC‐PDOs. These in vitro results are consistently supported by the PDO xenograft animal studies and patients’ clinical treatment outcomes, thereby verifying the predictive power of PDOs for drug responses in BC patients. By analyzing the genetic profiles of the PDOs, specific driver genes that correlate with drug sensitivity to two stand‐of‐care chemotherapeutics, cisplatin, and gemcitabine, are identified. Additionally, the practicality of PDOs in investigating the tumor microenvironment has been demonstrated. This study underscores the utility of PDOs in advancing the understanding of bladder cancer and the development of personalized therapeutic strategies. The BC‐PDOs biobank provides an ideal preclinical platform for supporting the development of personalized treatment strategies for BC patients. This study also provides insights into the potential mechanisms of drug resistance, paves the way for subsequent region‐specific research, and demonstrates the possibility of using PDO‐related models to direct future research in developing drugs targeting tumor microenvironments.
Controlled Self‐Assembly and Photo‐Thermal Activation of Viologen‐Based 2D Semiconductors for Dual‐Function Energy Management in All‐Weather Applications
Authors: Irshad Muhammad Sultan , Ahmed Iftikhar , Arshad Naila , Alomar Muneerah , Shu Yue , Zhenzhen Guo , Ahmad Shafiq , Zuburtikudis Ioannis , Ruiqing Shi , Mei Tao , Xiaochao Fan , Ho Nang Xuan , Pham Thuy‐Duong , Dao Van‐Duong , Li Rong , Wang Xianbao 
Published: February 2025

AbstractSolar thermal technology offers a promising solution to water scarcity; however, the continuous operation of solar evaporators remains challenging due to sunlight's intermittent availability. Herein, an alternative strategy is proposed to achieve dual‐functional energy management of photo‐thermoactivated viologen T semiconductors for enhanced solar water evaporation, water‐enabled electricity generation, and electrothermal evaporation. A sequential cyanide‐bridged layer‐directed intercalation approach is developed, where infinitely π‐stacked, redox‐active N‐methyl bipyridinium cations with near‐planar structures are sandwiched between cyanide‐bridged MnII–FeIII. The extended absorption range of 95% is achieved through radical–π interactions that occur within the continuously π‐stacked N‐methyl bipyridinium units upon thermal activation. The photo‐thermoactivated MnII–FeIII compounds anchored charcoal mask (MnII–FeIII@CM) with a sided evaporation structure and controllable water transfer, offering a high evaporation rate of 2.39 kg m−2 h−1 under one sun (1 kW m−2) illumination. As an energy nanogenerator, the output voltage and current of MnII–FeIII@CM can reach up to ≈480 mV and ≈60 µA cm−2 under ambient conditions. Furthermore, storage of electrical energy from MnII–FeIII@CM using energy storage devices is expected to enable all‐weather evaporation by electric heating due to unsustainable sunlight, providing a unique technology for seawater desalination and offshore work platform energy access.
A Synthetic Facultative CAM‐Like Shuttle in C3 Rice Plants
Authors: Wu Suting , Jin Kaining , Li Haoshu , Chen Guoxin , Zhang Liying , Yang Jinwen , Zhai Shanshan , Li Yanni , Sun Xuehui , Cui Xuean , Sun Jing , Lu Tiegang , Zhang Zhiguo 
Published: February 2025

AbstractCrassulacean acid metabolism (CAM) is one of the three major forms of photosynthesis, known for its efficient carbon sequestration mechanism. CAM plants store malate at night, which undergoes decarboxylation and promotes Rubisco carboxylation during the day. Despite its potential benefits, CAM engineering is not applied to C3 crops. This paper introduces a designed facultative CAM bypass (CBP) in rice by incorporating codon‐optimized nocturnal carboxylation and decarboxylation modules, a malate transporter module, and a stomatal regulation module using the transgene stacking system. The CBP plants are correctly assembled by detection at the gene level, transcription level, protein level, and enzyme activity. Malate, CAM metabolism product, accumulated significantly at night in CBP plants. Metabolic analysis revealed that the malate is directed to the citric acid cycle and impacted carbon sequestration. The CBP plants showed a significant increase of ≈21% and ≈27% in photosynthetic rate and carboxylation efficiency, respectively. Additionally, CBP plants exhibited ≈20% increase in grain yield and biomass over the 2‐year field trials. Unexpectedly, the water use efficiency and drought resistance do not improve in CBP plants. This study is the first to attempt CAM engineering in C3 and demonstrates the potential of facultative CAM carbon sequestration in rice.
Layered Anion‐Mixed Oxycompounds: Synthesis, Properties, and Applications
Authors: Luan Yange , Li Yumin , Li Zhong , Zhang Bao Yue , Ou Jian Zhen 
Published: February 2025

AbstractLayered anion‐mixed oxycompounds have emerged as pivotal materials across diverse technological domains encompassing electronics, optics, sensing, catalysis, and energy applications. Capitalizing on the unique properties imparted by the additional anion, these compounds exhibit exceptional characteristics including ultra‐large charge carrier mobility, giant second‐harmonic generation, visible‐light‐driven photocatalysis, and outstanding thermoelectricity. This article aims to provide a comprehensive summary of layered anion‐mixed oxychalcogenides, oxyhalides, oxynitrides, and oxypnictides. Organized by chemical composition and crystal structures, the classification of these oxycompounds precedes an in‐depth exploration of various synthesis methodologies. Subsequently, their properties are elucidated in electronics, optics, magnetics, and ferroelectrics, contextualizing their utility in electronic, optical, and catalytic applications. The review culminates in a critical assessment of extant challenges and opportunities within this realm. Furthermore, insights are proffered into the future trajectory of research, underpinning the significance of advancing novel 2D multi‐anion oxygenated compounds and their attendant applications.
Langmuir‐Type Build‐Up of Self‐Generated Interlayers in Organic Solar Cells
Authors: Vinokur Jane , Stein Eyal , Moskovich Noam , Schneider Sebastian Alexander , Savikhin Victoria , Levin Andrew , Toney Michael , Frey Gitti L. 
Published: February 2025

AbstractCharge selective ohmic contacts are crucial for optimizing the performance of organic electronic devices, particularly organic solar cells (OSC). This study investigates the modification of contacts by examining the formation of thin interlayers through metal‐induced additive migration. Two types of OSCs, based on fullerene and non‐fullerene systems, are utilized along with five concentration series of polyethylene glycol (PEG) oligomer additives that gradually migrate from the active layer to the contact, generating interlayers. By analyzing the trends of Voc (open circuit voltage) versus additive concentration and length, the arrangement of additives at the organic/metal interface and the origin of point‐dipoles projected onto the metal surface are determined. The behavior of the additive's dipole‐baring moiety in all additives is found to follow a Langmuir‐like adsorption process, with a remarkably stable “effective” ∆G (Gibbs free energy) across the different OSC systems and additives. These results imply that the active organic layer can be treated as a semisolid solution where the additive undergoes adsorption/desorption at the Al contact. The diffusivity of the PEG‐oligomer additive in this solution is temperature‐dependent, so elevated temperatures allow fast adsorption/desorption equilibrium. Grazing‐incidence wide angle X‐ray scattering (GIWAX) analysis reveals that the additive's impact on device performance is solely interfacial. By establishing scientific correlations between the additive's properties, quantity, and energetic shifts at the interface, this study provides practical guidelines for implementing the spontaneous interlayer formation methodology in large‐scale applications of organic electronics.
A Rechargeable Zn‐Redox Battery for Concurrent Electricity Generation and The‐Whole‐Process Chemical Production
Authors: He Xiaoyang , Xue Shujie , Liu Xuan , Xiong Dengke , Xiao Xin , Wu Deli , Wang Jianying , Xu Qiang , Chen Zuofeng 
Published: February 2025

AbstractThe rechargeable Zn‐redox battery represents a promising, efficient, and sustainable energy storage technology. Herein, a novel 4‐nitrobenzyl alcohol (4‐NBA)‐assisted rechargeable Zn‐redox battery, driven by NiSe─Cu2Se/NF bifunctional electrocatalysts is developed. The different redox activities of ─NO2 and ─OH groups in 4‐NBA allow redox conversion for chemical production during the whole discharge/charge process, maximizing the economic value of battery technologies. Detailed charge analyses indicate that the internal electric field within the NiSe─Cu2Se heterostructure modulates the d‐band center, optimizes the adsorption/desorption strength of intermediates, and reduces the reaction energy barriers during the redox conversion of 4‐NBA. This bifunctional NiSe─Cu2Se electrocatalyst enables the selective conversion of 4‐NBA to 4‐aminobenzyl alcohol during the discharge process and to 4‐nitrobenzoic acid during the charge process, with Faradaic efficiencies above 96%. Consequently, the 4‐NBA‐assisted rechargeable Zn‐redox battery achieves a high power energy density of 16.13 mW cm−2 and maintains a stable yield rate of 15.92 µmol h−1 cm−2 for 4‐aminobenzyl alcohol and 22.84 µmol h−1 cm−2 for 4‐nitrobenzoic acid. This work presents an appealing strategy for integrating energy storage with the‐whole‐process chemical production, paving the way for developing multifunctional energy systems.
Prokaryote‐Inspired and Derived Oxygen Reduction Electrocatalysts for Ultra‐Long‐Life Zn–Air Batteries
Authors: Zhao Wenbo , Chen Jipeng , Liu Ximeng , Gao Yong , Pu Jie , Cao Qinghe , Meng Ting , Elshahawy Abdelnaby M. , Makhlouf Salah A. , Guan Cao 
Published: February 2025

AbstractThe design of efficient oxygen reductionreaction (ORR) catalyst with fast kinetics is crucial for high‐performance Zn–air batteries but remains a challenge. Herein, inspired by the oxidative respiratory chain of prokaryotes, an ORR electrocatalyst is reported by mimicking the microstructure of Staphylococcus aureus and simitaneously utilizing this low‐cost cell as the precursor. The catalyst consists of MnO2/Co2P nanocomposites support on Staphylococcus aureus‐derived hollow spherical carbon, which not only accelerates electron transfer for improved intrinsic reaction kinetics, but also creates an OH− concentration gradient for enhanced mass transfer efficiency. Such bio‐inspired and derived ORR catalyst enables rechargeable Zn–air batteries with ultra‐long cycling stability of more than 2800 h at a high capacity of 810.3 mAh g−1, which is superior among the reported bio‐derived oxygen catalysts. A flexible Zn–air battery based on the bio‐inspired and derived catalyst is also assembled, and it well integrates with a wireless flexible electronic skin.
Electron‐Rich Ru Clusters Anchored on Pure Phase W2C Enables Highly Active and CO‐Resistant Alkaline Hydrogen Oxidation
Authors: Gao Yanan , Ouyang Bo , Shen Yuan , Wen Wei , Wang Junxiang , Wang Mingzhe , Sun Yiqiang , Xu Kun 
Published: February 2025

AbstractDeveloping highly active and CO‐resistant Ru‐based catalysts for the alkaline hydrogen oxidation reaction (HOR) can advance the large‐scale application of alkaline hydrogen fuel cells but remains a huge challenge. Herein, a pure phase W2C supported Ru cluster catalyst (Ru/W2C) is successfully synthesized through a one‐step carburization method. It is found that the charge transfer from W2C to the strongly anchored Ru clusters forms the electron‐rich Ruδ− sites and electron‐deficient Wδ+ sites, which significantly weakens the adsorption strength of *H and *CO, strengthens the binding of *OH and improves the water connectivity in the electric double layer. The Ru/W2C catalyst shows superior mass activity (2163 mA mgPGM−1) in alkaline HOR, which is 12.52 and 20.62 times higher than that for Pt/C and Ru/C, respectively. Owing to the weak adsorption and fast removal rate of CO, the Ru/W2C exhibits outstanding CO tolerance, with 88% of the initial activity being retained in the durability test, whereas the Ru/C and Pt/C suffer from severe deactivation. These findings may guide the design of advanced alkaline HOR catalysts based on the pure phase tungsten carbide.
Efficient Forward‐Bias Bipolar Membrane CO2 Electrolysis in Absence of Metal Cations
Authors: Brückner Sven , Ju Wen , Strasser Peter 
Published: February 2025

AbstractThe acid‐base reaction of CO2 with hydroxide ions to (bi)carbonate anions at the cathode of alkaline exchange membrane (AEM) CO2 electrolyzer has detrimental impact on their performance. (Bi)carbonate buffers the local cathode pH, and in combination with metal cations, may lead to precipitation of salts at the cathode. This non‐electrochemical conversion of CO2 significantly reduces the CO2 utilization efficiency and limits the CO2 single pass conversion of AEM CO2 electrolyzer to 50% if CO is desired. Acidic metal cation‐free CO2 electrolysis has the potential to address and mitigate these problems. Here, CO2 valorization is demonstrated at faradaic CO efficiencies (FE) of up to 80% FECO in forward‐bias BPM cell architectures using actual neutral pure water feeding at the anode. This study demonstrates how immobilized anion exchange ionomer layers thereby facilitate the metal cation‐free CO2 valorization thanks to their positively charged functional NR4 groups. Unlike metal cations, the immobilized positively charged groups are not washed out of the reactor. This study shows that careful design of the distribution and location of the anion exchange ionomer molecules within the Gas Diffusion Electrode is key to efficient CO2‐to‐CO electrolyzer cell.
Yield‐stability selection index applied to identify top genotypes in a Hevea brasiliensis segregating population in Antioquia, Colombia
Authors: Monsalve García Danilo Augusto , Cotes Torres José Miguel , Navas Arboleda Alejandro Alberto , Córdoba‐Gaona Oscar de Jesús 
Published: February 2025

AbstractRubber (Hevea brasiliensis) production in Colombia has been primarily dependent on three predominant genotypes for over five decades. However, challenges such as disease susceptibility and low yield and quality underscore the need for increased genetic variability. Yield‐stability indexes are essential tools for identifying superior genotypes in Hevea breeding programs. In 1999, a segregating rubber plantation with 3395 trees was established at the Agrosavia El Nus Research Center. Georeferencing, tapping data, and total solids yield were assessed through 10 evaluations per tree. This study aimed to identify high‐performing rubber genotypes using an adjusted total solids yield‐stability index. Phenotypic values were adjusted to account for microclimate effects and temporal variation. The resulting index, applied through stratified mass selection, provided a closer approximation of genotypic performance. Based on the index, the top 50 and bottom 10 genotypes were identified, offering insights into elite individuals' contributions to total solids production. Notably, genotypes 2a13, 2a317, and 3a89 exhibited higher predicted yield‐stability () index values, with and , reflecting superior performance and stability, making them valuable candidates for rubber breeding programs aimed at improving total solids production. Additionally, the index facilitated the identification of genotypes with high phenotypic values but marked production instability, as observed in genotype 3c355 (.
Enhancing population and family selection accuracy with statistical genetics models accounting for epistatic effects for wheat breeding
Authors: Fronza Rafael Tobias Lang , Mezzomo Henrique Caletti , Batista Cláudio Vieira , Moresco Estéfano , Dias Kaio Olimpio das Graças , Nardino Maicon 
Published: February 2025

AbstractFew studies have investigated the effect on the genotypic value of wheat (Triticum aestivum L.) families with the adoption of the additive and epistatic (additive × additive) relationship matrix. The objective of this study is to select F2:3 families of wheat by means of three statistical genetics models (without pedigree information, additive, and additive plus additive × additive epistatic) and to evaluate the selection rank between the traditional model and the model with best fit of families for recombination and for deriving progenies. The experiment was composed of a total of 880 F2:3 families of tropical wheat, from 56 populations conducted by the genealogical method, which came from a full diallel involving the cultivars BRS 254, BRS 264, and BRS 394, CD 1303, Tbio Aton, Tbio Ponteiro, Tbio Duque, and Tbio Sossego. The pedigree matrix was calculated, obtaining approximately 20 generations of ancestry of the parents. The data were analyzed in three genetic‐statistical models: Model 1—without information on family relationship; Model 2—computing the additive relationship matrix; and Model 3—including the additive and epistatic (additive × additive) relationship matrix. Using the additive and epistatic (additive × additive) pedigree matrix has a significant effect on most traits. The selection revealed families of populations with potential to be used in recombinations: BRS 254/CD 1303, Tbio Ponteiro/BRS 394, and BRS 394/Tbio Ponteiro, with genetic value to derive progenies: BRS 254/Tbio Aton, Tbio Aton/Tbio Duque, and BRS 394/Tbio Aton, and with both attributes: BRS 254/CD 1303, BRS 394/Tbio Ponteiro, and Tbio Sossego/BRS 264.
Diamagnetic Signature of Beta‐Amyloid (Aβ) and Tau (τ) Tangle Pathology in Alzheimer's Disease: A Review
Authors: Ghaderi Sadegh , Mohammadi Sana , Fatehi Farzad 
Published: February 2025

ABSTRACTThe complex interplay between diamagnetic and paramagnetic substances within the brain, particularly in the context of Alzheimer's disease (AD), offers a rich landscape for investigation using advanced quantitative neuroimaging techniques. Although conventional approaches have focused on the paramagnetic properties of iron, emerging and promising research has highlighted the significance of diamagnetic signatures associated with beta‐amyloid (Aβ) plaques and Tau (τ) protein aggregates. Quantitative susceptibility mapping (QSM) is a complex post‐processing technique that visualizes and characterizes these subtle alterations in brain border tissue composition, such as the gray–white matter interface. Through voxel‐wise separation of the contributions of diamagnetic and paramagnetic sources, QSM enabled the identification and quantification of Aβ and τ aggregates, even in the presence of iron. However, several challenges remain in utilizing diamagnetic signatures of Aβ and τ for clinical applications. These include the relatively small magnitude of the diamagnetic signal compared to paramagnetic iron, the need for high‐resolution imaging and sophisticated analysis techniques, and the standardization of QSM acquisition and analysis protocols. Further research is necessary to refine QSM techniques, optimize acquisition parameters, and develop robust analysis pipelines to improve the sensitivity and specificity of detecting the diamagnetic nature of Aβ and τ aggregates. As our understanding of the diamagnetic properties of Aβ and τ continues to evolve, QSM is expected to play a pivotal role in advancing our knowledge of AD and other neurodegenerative diseases.
Thioether‐bridged surfactants for interfacial hydrophobic regulation and enhanced mineral flotation recovery
Authors: Sun Qing , Yang Diling , Chen Jingsi , Zhao Ziqian , Zhang Hao , Zhong Hong , Zeng Hongbo 
Published: February 2025

AbstractSurfactant modification to improve interfacial hydrophobicity is widely employed in separation applications such as mineral recovery. However, few modifications effectively enhance both the inherent hydrophobicity of the surfactant and its surface‐anchoring capacity. In this study, we propose a strategy to incorporate a thioether group into a hydroxamate surfactant, resulting in the synthesis of N‐hydroxy‐2‐(octylthio)acetamide (OTHA). Compared to the thioether‐free surfactant (OHA), the thioether group significantly improves the metal‐anchoring capability of the surfactant, demonstrating a twofold increase in adsorption on hydrophilic cassiterite surfaces. Meanwhile, the inherent hydrophobicity of the thioether group enhances the hydrophobization of the target mineral surface and improves bubble‐surface interactions. The robust hydrophobicity‐inducing ability of OTHA successfully increases the flotation recovery of hydrophilic cassiterite particles, with a marked improvement from 72.5% to 95.0%. This work presents a paradigm for surfactant modification, enabling tailored hydrophobic interfaces for practical applications such as mineral separation, oil‐gas extraction, waterproof materials, and functional coatings.