bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term development of thermophysical and mechanical properties of cold‐curing structural adhesives due to post‐curing
Authors: Moussa Omar , Vassilopoulos Anastasios P. , Castro Julia de , Keller Thomas 
Published: May 2012

AbstractThe long‐term changes in the thermophysical and mechanical properties of a cold‐curing structural epoxy adhesive were investigated by accelerating the curing reaction by post‐curing at elevated temperatures. Experimental data concerning the glass transition temperature for periods of up to 7 years and tensile strength and stiffness measurements could be extrapolated for a period of up to 17 years. An existing model for the long‐term development of concrete properties was modified for the prediction of the long‐term mechanical properties of adhesives. The applicability of the acceleration procedure and the new model was confirmed by several verification procedures. Structural adhesives exhibit significant increases in glass transition temperature, strength and stiffness over the long term provided that joints are adequately sealed and protected from humidity and UV radiation. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Stem cells: A view from the roots
Authors: Somorjai Ildiko M. L. , Lohmann Jan U. , Holstein Thomas W. , Zhao Zhong 
Published: May 2012

AbstractIn both plants and animals, regeneration requires the activation of stem cells. This is possibly related to the origin and requirements of multicellularity. Although long diverged from a common ancestry, plant and animal models such as Arabidopsis, Drosophila and mouse share considerable similarities in stem cell regulation. This includes stem cell niche organisation, epigenetic modification of DNA and histones, and the role of small RNA machinery in differentiation and pluripotency states. Dysregulation of any of these can lead to premature ageing, patterning and specification defects, as well as cancers. Moreover, emerging basal animal and plant systems are beginning to provide important clues concerning the diversity and evolutionary history of stem cell regulatory mechanisms in eukaryotes. This review provides a comparative framework, highlighting both the commonalities and differences among groups, which should promote the intelligent design of artificial stem cell systems, and thereby fuel the field of biomaterials science.
Modest seductiveness: Reconciling modesty and vanity by reverse assimilation and double resistance
Authors: Sobh Rana , Belk Russell William , Gressel Justin 
Published: May 2012

ABSTRACTWe study conflicting notions of modesty and vanity in the Arab Gulf region by focusing on contemporary female adornment practices and the tensions underlying them. The standard of modest traditional dress that women are expected to adhere to in Gulf countries is intended to conceal their sexuality and promote public virtue. Nevertheless, emerging bodily adornment practices in the region serve the contradictory purposes of emphasizing female sexuality and celebrating fashion. By using insights from observations and depth interviews with young Qatari and Emirati women, we explore the dynamics underlying the conflicting imperatives of modesty and vanity and examine how they reconcile these contradictions in constructing their identities as women, Muslims, Qataris, and Emiratis. We find that the concepts of reverse assimilation and double resistance are most useful in understanding responses to these conflicting imperatives among young Gulf women. Copyright © 2012 John Wiley & Sons, Ltd.
Succinobucol‐eluting stents increase neointimal thickening and peri‐strut inflammation in a porcine coronary model
Authors: Watt Jonathan , Kennedy Simon , McCormick Christopher , Agbani Ejaife O. , McPhaden Allan , Mullen Alexander , Czudaj Peter , Behnisch Boris , Wadsworth Roger M. , Oldroyd Keith G. 
Published: May 2012

ObjectiveThe aim of this study was to assess the efficacy of stent‐based delivery of succinobucol alone and in combination with rapamycin in a porcine coronary model. Background: Current drugs and polymers used to coat coronary stents remain suboptimal in terms of long term efficacy and safety. Succinobucol is a novel derivative of probucol with improved antioxidant and anti‐inflammatory properties.MethodsPolymer‐free Yukon stents were coated with 1% succinobucol (SucES), 2% rapamycin (RES), or 1% succinobucol plus 2% rapamycin solutions (SucRES) and compared with a bare metal stent (BMS).ResultsThe in vivo release profile of SucES indicated drug release up to 28 days (60% drug released at 7 days); 41 stents (BMS, n = 11; SucES, n =10; RES, n = 10; SucRES, n = 10) were implanted in the coronary arteries of 17 pigs. After 28 days, mean neointimal thickness was 0.31 ± 0.14 mm for BMS, 0.51 ± 0.14 mm for SucES, 0.19 ± 0.11 mm for RES, and 0.36 ± 0.17 mm for SucRES (P < 0.05 for SucES vs. BMS). SucES increased inflammation and fibrin deposition compared with BMS (P < 0.05), whereas RES reduced inflammation compared with BMS (P < 0.05).ConclusionIn this model, stent‐based delivery of 1% succinobucol using a polymer‐free stent platform increased neointimal formation and inflammation following coronary stenting. © 2012 Wiley Periodicals, Inc.
Acute and medium‐term outcomes of endovascular therapy of obstructive disease of diverse etiology of the common femoral artery
Authors: Dattilo Philip B. , Tsai Thomas T. , Kevin Rogers R. , Casserly Ivan P. 
Published: May 2012

BackgroundCommon femoral endarterectomy is regarded as the standard revascularization strategy for the treatment of common femoral artery (CFA) disease. The availability of a variety of endovascular tools has resulted in an increased number of patients with CFA disease being treated using an endovascular strategy. We sought to evaluate clinical outcomes in a contemporary series of patients who were treated for CFA disease using an endovascular‐first approach.MethodsAll patients with obstructive CFA disease who were treated using endovascular therapy were retrospectively identified from a peripheral interventional database. Baseline patient characteristics, anatomic details, procedural data, and clinical outcomes were assessed. Kaplan–Meier (KM) curves for mortality, amputation‐free survival, and primary and secondary patency were generated.ResultsBetween 2006 and 2011, a total of 30 patients underwent 31 CFA procedures. The primary etiologies of CFA obstruction were atherosclerosis (58%), access‐site‐related complication (32%), and thromboembolism (10%). Patients presented with severe claudication (60%), critical limb ischemia (13%), or acute limb ischemia (27%). The procedure was technically successful in 90% of cases with major complications in two (7%) patients. There was no procedure‐related mortality. The KM estimate of survival and amputation‐free survival at 1 year was 96% (±4%) and 96% (±4%), respectively. In those patients who had a successful revascularization, the overall 1‐year estimate for primary and secondary patency was 88% (±6) and 92% (±5%), respectively. There was a nonsignificant trend toward lower patency in patients treated for atherosclerotic disease compared to those with access‐site‐related complications and thromboembolic disease at 2‐year follow‐up (76 vs. 100%, P = 0.08).ConclusionsEndovascular therapy for treatment of obstructive disease of the CFA is associated with a high rate of acute technical success. Primary patency rates in the cohort treated for access‐site‐related complications and thromboembolic disease are excellent and support an endovascular‐first approach for this patient subset. Based on lower patency rates, surgical endarterectomy for the treatment of atherosclerotic disease in the CFA remains the gold standard in patients with normal surgical risk. © 2013 Wiley Periodicals, Inc.
Distribution and functional organization of glomeruli in the olfactory bulbs of zebrafish (Danio rerio)
Authors: Braubach Oliver R. , Fine Alan , Croll Roger P. 
Published: May 2012

AbstractThe cover image shows the paired olfactory bulbs of an adult female zebrafish (Danio rerio). The image was obtained through a novel in toto immunohistochemistry protocol explained in Braubach, Fine and Croll in this issue. The tissue was labeled with antibodies against the molluscan blood protein, keyhole limpet hemocyanin (red), and the calcium binding protein, calretinin (green). Axons that enter the olfactory bulbs via the olfactory nerve (bottom) converge on different target areas, which differ in their neurochemistry and the numbers and morphologies of olfactory glomeruli contained within each region. J. Comp. Neurol. 520:2317–2339, 2012. © 2012 Wiley Periodicals, Inc.
Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
Authors: Campbell‐Thompson Martha , Wasserfall Clive , Kaddis John , Albanese‐O'Neill Anastasia , Staeva Teodora , Nierras Concepcion , Moraski Jayne , Rowe Patrick , Gianani Roberto , Eisenbarth George , Crawford James , Schatz Desmond , Pugliese Alberto , Atkinson Mark 
Published: May 2012

AbstractBackgroundThe Network for Pancreatic Organ Donors with Diabetes (nPOD) was established to recover and characterize pancreata and related organs from cadaveric organ donors with various risk levels for type 1 diabetes (T1D). These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis.Research design and methodsOrgan donors included T1D patients (new onset to long term), non‐diabetic autoantibody‐positive subjects, non‐diabetic controls and individuals with disorders relevant to β‐cell function. Pancreas recovery and transport met transplant‐grade criteria. Additional samples recovered included serum, whole blood, spleen and pancreatic and non‐pancreatic lymph nodes. Biospecimens were processed for cryopreserved cells, fixed paraffin and fresh frozen blocks and snap frozen samples. T1D autoantibodies, C‐peptide levels and high‐resolution HLA genotyping for risk alleles were also determined.ResultsOver 160 donors have been enrolled (ages of 1 day to >90 years). Standard operating procedures were established along with a quality management system. Donor demographics, laboratory assays and histopathological characterizations were shared through an open online informatics system. Biospecimens were distributed to more than 60 investigators.ConclusionsThe nPOD programme provides access to high quality biospecimens without cost to investigators. Collaborations and open data sharing are emphasized to maximize research potential of each donor. On the basis of initial successes, the nPOD programme is expanding to recover additional organs relevant to T1D pathogenesis and complications from European countries (PanFin network). Copyright © 2012 John Wiley & Sons, Ltd.
Towards a Conceptual Framework for The Study of Shifts in Modes of Environmental Governance – Experiences From The Netherlands
Authors: Driessen Peter P. J. , Dieperink Carel , van Laerhoven Frank , Runhaar Hens A. C. , Vermeulen Walter J. V. 
Published: May 2012

ABSTRACTIn the last decade, many authors have observed shifts from government to governance in the environmental policy domain. However, a clear conceptual framework to differentiate between modes of environmental governance is lacking and our understanding of when, how and why environmental governance changes from one mode to another is limited. In this paper we propose such a framework and we illustrate its usefulness by applying it to two environmental policy sectors in the Netherlands: urban environmental policy and policy regarding sustainable production and consumption. We show how the application of our framework leads to detailed, replicable and comparable claims about character and intensity of shifts in environmental governance. From this analysis, we conclude that character and intensity of shifts in environmental governance vary significantly. Furthermore, we show that modes of governance build on rather than completely replace one another. Finally, we point to a number of possible explanations for shifts in environmental governance, recognized in literature and in practice. We conclude with some suggestions for further research. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Critical evaluation and further development of methods for testing ecotoxicity at multiple pH using Daphnia magna and Pseudokirchneriella subcapitata
Authors: Rendal Cecilie , Trapp Stefan , Kusk Kresten Ole 
Published: May 2012

Abstract
To meet the requirements of risk assessment legislature regarding the ecotoxicity of ionizing compounds, the present study attempts to establish easy, robust methods for testing ecotoxicity at various pH levels. An overview is given of the buffering methods found in the literature. This is supplemented by a series of experiments where toxicity and ability to stabilize pH of seven common buffering compounds was tested on Daphnia magna and Pseudokirchneriella subcapitata. We consider a buffer applicable at a given concentration if the pH drift is below 0.2 pH units, and if there are no toxic effects. Twenty-four- and 48-h acute toxicity tests with D. magna were carried on a series of organic buffers with pH monitoring. Based on the experimental results it is possible to give recommendations for buffer concentrations for use in toxicity testing with D. magna at pH levels in the range of pH 6.0–7.8 for 48 h exposure, and pH 6.0–9.5 for 24 h exposure. Forty-eight- and 72-h growth inhibition tests with P. subcapitata were carried out, and recommendations for buffer concentrations at pH 7.5 and 8.0 are made for both 48 and 72 h of exposure. Environ. Toxicol. Chem. 2012; 31: 1843–1852. © 2012 SETAC
Musk strawberries: the flavour of a formerly famous fruit reassessed
Authors: Pet'ka Ján , Leitner Erich , Parameswaran Baskaran 
Published: May 2012

ABSTRACTFruits of wildly growing and naturally ripened musk strawberries (Fragaria moschata) from two highland sites were studied during two seasons. The fruits were characterized on site by two flavourists and a full profile of the volatile compounds was extracted immediately after collection using solid phase extraction and analysed by gas chromatography–mass spectrometry (GC‐MS) and gas chromatography–olfactometry (GC‐O). The aroma of whole fruits was characterized with dynamic headspace coupled to GC‐MS. Single fruits evaluated on site were characterized by green, spicy, seedy and sweet exotic notes, while the fruit bunches showed a complex tropical smell. More than 100 distinctive volatile compounds were detected by GC‐MS. Some of them are reported for the first time in the Fragaria species, most notably the abundant coniferyl alcohol. GC‐O revealed that mesifuran, eugenol, methyl butyrate, furaneol and 3‐mercaptohexyl acetate were the key components of the highland musk strawberry flavour. A comparison of the volatile pattern with the much more known woodland strawberry (F. vesca) from a nearby location contrasted the differences in the volatile composition of the musk strawberry. Repeated analysis of fruits harvested 2 years after the first vintage confirmed these data. Copyright © 2012 John Wiley & Sons, Ltd.
Biallelic inactivation of NF1 in a sporadic plexiform neurofibroma
Authors: Beert Eline , Brems Hilde , Renard Marleen , Ferreiro Julio Finalet , Melotte Cindy , Thoelen Reinhilde , De Wever Ivo , Sciot Raf , Legius Eric , Debiec‐Rychter Maria 
Published: May 2012

AbstractPlexiform neurofibromas are a major cause of morbidity in individuals with neurofibromatosis type 1 (NF1). Sporadically, these tumors appear as an isolated feature without other signs of NF1. A role for the NF1 gene in solitary plexiform neurofibromas has never been described. In this study, we report a 13‐year‐old boy who was diagnosed with a plexiform neurofibroma, without other NF1 diagnostic criteria. The tumor was partially resected and analyzed using different techniques: karyotyping, fluorescence in situ hybridization (FISH), and microarray comparative genomic hybridization (aCGH). Tumor Schwann cell culture and subsequent karyotyping showed a rearrangement involving chromosomes 1 and 17, namely an insertion of chromosomal bands 1p36‐35 at 17q11.2. FISH demonstrated that the insertion interrupted the NF1 gene. In addition, a deletion was detected affecting the other NF1 allele. Whole‐genome aCGH analysis of the resected tumor confirmed the presence of an 8.28 Mb deletion including the NF1 gene locus in ∼15–20% of tumor cells. We conclude that biallelic NF1 inactivation was at the origin of the isolated plexiform neurofibroma in this patient. The insertion is most likely the “first hit” and the large deletion the “second hit.” © 2012 Wiley Periodicals, Inc.
Evaluation and critique of Healthcare Failure Mode and Effect Analysis applied in a radiotherapy case study
Authors: Chadwick Liam , Fallon Enda F. 
Published: May 2012

AbstractHealthcare Failure Mode and Effect Analysis (HFMEA®) has been developed to support the proactive analysis of health care treatment processes. Its use has been reported in several studies with both positive and negative comments regarding the quality of the results and the efficacy of the method. This paper examines the HFMEA® methodology and discusses the challenges that were encountered during its application to a proactive analysis of radiotherapy patient record systems in a large public hospital. Several weaknesses in the HFMEA® method and particularly in the HFMEA Decision TreeTM are also discussed. Recommendations to support future HFMEA® studies and also for the re‐design of the HFMEA Decision TreeTM to overcome the identified weaknesses are included. Based on these recommendations, a new decision tree is presented to guide future analyses. © 2012 Wiley Periodicals, Inc.
Adoption of ISO 9000 Practices in Manufacturing Companies: The Perspective of the Shop‐Floor Workers
Authors: Heras‐Saizarbitoria Iñaki , Cilleruelo Ernesto , Zamanillo Ibon 
Published: May 2012

AbstractThis article analyzes the adoption of ISO 9000 practices in manufacturing organizations from the perspective of the shop‐floor workers. For that purpose, extensive exploratory fieldwork based on both in‐depth interviews of employees, as well as on participant observation, was carried out in four Basque manufacturing organizations that have adopted the standard. The results show that the employees have a complex, critical, and heterogeneous perspective on the adoption of ISO 9000. In a set of organizations, most of the employees give an account of interesting evidence of how the ceremonial adoption of ISO 9000 occurs, whereas in other organizations the majority describe how ISO 9000 is adopted substantively. The results and the conclusions of the article have implications for academic theory, managers, and public policy. © 2012 Wiley Periodicals, Inc.
Flow and heat transfer of couple‐stress permeable fluid sandwiched between viscous fluid layers
Authors: Umavathi J.C. 
Published: May 2012

AbstractThe fully developed flow and heat transfer in a horizontal channel consisting of couple‐stress permeable fluid sandwiched between viscous fluid layers is investigated analytically. The channel walls are maintained at two different constant temperatures. The transport properties of the fluids in all regions are assumed to be constant. The governing equations are linear ordinary differential equations and hence closed form solutions are obtained. Effects of physical parameters such as viscosity ratio, thermal conductivity ratio, Eckert number, and Prandtl number on the flow are reported. An interesting and new approach is incorporated to analyze the flow for strong, weak, and comparable porosity with couple‐stress parameter. The variation of rate of heat transfer for different values of couple stress parameter and porosity is also discussed. © 2012 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21007
Analysis of precipitation extremes with the assessment of regional climate models over the Willamette River Basin, USA
Authors: Halmstad Andrew , Najafi Mohammad Reza , Moradkhani Hamid 
Published: May 2012

AbstractAn appropriate, rapid and effective response to extreme precipitation and any potential flood disaster is essential. Providing an accurate estimate of future changes to such extreme events due to climate change are crucial for responsible decision making in flood risk management given the predictive uncertainties. The objective of this article is to provide a comparison of dynamically downscaled climate models simulations from multiple model including 12 different combinations of General Circulation Model (GCM)–regional climate model (RCM), which offers an abundance of additional data sets. The three major aspects of this study include the bias correction of RCM scenarios, the application of a newly developed performance metric and the extreme value analysis of future precipitation. The dynamically downscaled data sets reveal a positive overall bias that is removed through quantile mapping bias correction method. The added value index was calculated to evaluate the models' simulations. Results from this metric reveal that not all of the RCMs outperform their host GCMs in terms of correlation skill. Extreme value theory was applied to both historic, 1980–1998, and future, 2038–2069, daily data sets to provide estimates of changes to 2‐ and 25‐year return level precipitation events. The generalized Pareto distribution was used for this purpose. The Willamette River basin was selected as the study region for analysis because of its topographical variability and tendency for significant precipitation. The extreme value analysis results showed significant differences between model runs for both historical and future periods with considerable spatial variability in precipitation extremes. Copyright © 2012 John Wiley & Sons, Ltd.
Targeted therapy for triple‐negative breast cancer: Where are we?
Authors: Duffy Michael J. , McGowan Patricia M. , Crown John 
Published: May 2012

AbstractBreast cancers that are negative for estrogen receptor (ER), progesterone receptors (PR) and HER2, using standard clinical assays, have been dubbed triple‐negative (TN). Unlike other molecular subtypes of invasive breast cancer, validated targeted therapies are currently unavailable for patients with TN breast cancer. Preclinical studies however, have identified several potential targets such as epidermal growth factor receptor (EGFR), SRC, MET and poly ADP ribose polymerase 1/2 (PARP1/2). Because of tumor heterogeneity, it is unlikely that any single targeted therapy will be efficacious in all patients with TN breast cancer. The rational way forward for treating these patients is likely to be biomarker‐driven, combination targeted therapies or combination of targeted therapy with cytotoxic chemotherapy.
AKT as locus of cancer angiogenic robustness and fragility
Authors: Radisavljevic Ziv 
Published: May 2012

AbstractAngiogenesis get full robustness in metastatic cancer, relapsed leukemia or lymphoma when complex positive feedback loop signaling systems become integrative. A cancer hypoxic microenvironment generates positive loops inducing formation of the vascular functional shunts. AKT is an upstream angiogenic locus of integrative robustness and fragility activated by the positive loops. AKT controls two downstream nodes the mTOR and NOS in nodal organization of the signaling genes. AKT phosphorylation is regulated by a balance of an oxidant/antioxidant. Targeting AKT locus represents new principle to control integrative angiogenic robustness by the locus chemotherapy. J. Cell. Physiol. 228: 21–24, 2013. © 2012 Wiley Periodicals, Inc.