bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute hematologic toxicity prediction using dosimetric and radiomics features in patients with cervical cancer: does the treatment regimen matter?
Authors: Yue Haizhen , Li Xiaofan , You Jing , Feng Pujie , Du Yi , Wang Ruoxi , Wu Hao , Cheng Jinsheng , Ding Kuke , Jing Bin 
Published: May 2024

BackgroundAcute hematologic toxicity (HT) is a prevalent adverse tissue reaction observed in cervical cancer patients undergoing chemoradiotherapy (CRT), which may lead to various negative effects such as compromised therapeutic efficacy and prolonged treatment duration. Accurate prediction of HT occurrence prior to CRT remains challenging.MethodsA discovery dataset comprising 478 continuous cervical cancer patients (140 HT patients) and a validation dataset consisting of 205 patients (52 HT patients) were retrospectively enrolled. Both datasets were categorized into the CRT group and radiotherapy (RT)-alone group based on the treatment regimen, i.e., whether chemotherapy was administered within the focused RT duration. Radiomics features were derived by contouring three regions of interest (ROIs)—bone marrow (BM), femoral head (FH), and clinical target volume (CTV)—on the treatment planning CT images before RT. A comprehensive model combining the radiomics features as well as the demographic, clinical, and dosimetric features was constructed to classify patients exhibiting acute HT symptoms in the CRT group, RT group, and combination group. Furthermore, the time-to-event analysis of the discriminative ROI was performed on all patients with acute HT to understand the HT temporal progression.ResultsAmong three ROIs, BM exhibited the best performance in classifying acute HT, which was verified across all patient groups in both discovery and validation datasets. Among different patient groups in the discovery dataset, acute HT was more precisely predicted in the CRT group [area under the curve (AUC) = 0.779, 95% CI: 0.657–0.874] than that in the RT-alone (AUC = 0.686, 95% CI: 0.529–0.817) or combination group (AUC = 0.748, 95% CI: 0.655–0.827). The predictive results in the validation dataset similarly coincided with those in the discovery dataset: CRT group (AUC = 0.802, 95% CI: 0.669–0.914), RT-alone group (AUC = 0.737, 95% CI: 0.612–0.862), and combination group (AUC = 0.793, 95% CI: 0.713–0.874). In addition, distinct feature sets were adopted for different patient groups. Moreover, the predicted HT risk of BM was also indicative of the HT temporal progression.ConclusionsHT prediction in cervical patients is dependent on both the treatment regimen and ROI selection, and BM is closely related to the occurrence and progression of HT, especially for CRT patients.
Mushroom-derived bioactive components with definite structures in alleviating the pathogenesis of Alzheimer’s disease
Authors: Jiang Xue , Song Yu , Lv Changshun , Li Yinghui , Feng Xiangru , Zhang Hao , Chen Yujuan , Wang Qingshuang 
Published: May 2024

Alzheimer’s disease (AD) is a complicated neurodegenerative condition with two forms: familial and sporadic. The familial presentation is marked by autosomal dominance, typically occurring early in individuals under 65 years of age, while the sporadic presentation is late-onset, occurring in individuals over the age of 65. The majority of AD cases are characterized by late-onset and sporadic. Despite extensive research conducted over several decades, there is a scarcity of effective therapies and strategies. Considering the lack of a cure for AD, it is essential to explore alternative natural substances with higher efficacy and fewer side effects for AD treatment. Bioactive compounds derived from mushrooms have demonstrated significant potential in AD prevention and treatment by different mechanisms such as targeting amyloid formation, tau, cholinesterase dysfunction, oxidative stress, neuroinflammation, neuronal apoptosis, neurotrophic factors, ER stress, excitotoxicity, and mitochondrial dysfunction. These compounds have garnered considerable interest from the academic community owing to their advantages of multi-channel, multi-target, high safety and low toxicity. This review focuses on the various mechanisms involved in the development and progression of AD, presents the regulatory effects of bioactive components with definite structure from mushroom on AD in recent years, highlights the possible intervention pathways of mushroom bioactive components targeting different mechanisms, and discusses the clinical studies, limitations, and future perspectives of mushroom bioactive components in AD prevention and treatment.
Importance of cardiac-synchronized vagus nerve stimulation parameters on the provoked chronotropic response for different levels of cardiac innervation
Authors: Haberbusch Max , Kronsteiner Bettina , Aigner Philipp , Kiss Attila , Podesser Bruno Karl , Moscato Francesco 
Published: May 2024

IntroductionThe influence of vagus nerve stimulation (VNS) parameters on provoked cardiac effects in different levels of cardiac innervation is not well understood yet. This study examines the effects of VNS on heart rate (HR) modulation across a spectrum of cardiac innervation states, providing data for the potential optimization of VNS in cardiac therapies.Materials and MethodsUtilizing previously published data from VNS experiments on six sheep with intact innervation, and data of additional experiments in five rabbits post bilateral rostral vagotomy, and four isolated rabbit hearts with additionally removed sympathetic influences, the study explored the impact of diverse VNS parameters on HR.ResultsSignificant differences in physiological threshold charges were identified across groups: 0.09 ± 0.06 μC for intact, 0.20 ± 0.04 μC for vagotomized, and 9.00 ± 0.75 μC for isolated hearts. Charge was a key determinant of HR reduction across all innervation states, with diminishing correlations from intact (r = 0.7) to isolated hearts (r = 0.44). An inverse relationship was observed for the number of pulses, with its influence growing in conditions of reduced innervation (intact r = 0.11, isolated r = 0.37). Frequency and stimulation delay showed minimal correlations (r &lt; 0.17) in all conditions.ConclusionOur study highlights for the first time that VNS parameters, including stimulation intensity, pulse width, and pulse number, crucially modulate heart rate across different cardiac innervation states. Intensity and pulse width significantly influence heart rate in innervated states, while pulse number is key in denervated states. Frequency and delay have less impact impact across all innervation states. These findings suggest the importance of customizing VNS therapy based on innervation status, offering insights for optimizing cardiac neuromodulation.
A randomized controlled trial of Eye Movement Desensitization and Reprocessing (EMDR) Therapy in the treatment of fibromyalgia
Authors: Zat Çiftçi Zeynep , Delibaş Dursun Hakan , Kaya Taciser , Külcü Duygu Geler , Sarı Aylin , Nazlıkul Hüseyin , Coşkun Topsakal İlkem , Aydın Yunus Emre , Kavakçı Önder , Savran Canan , Konuk Emre 
Published: May 2024

BackgroundIn addition to pharmacological treatment, psychotherapeutic approaches are recommended for the treatment of fibromyalgia. There is a suggestion that eye movement desensitization and reprocessing (EMDR) therapy may be effective. This study aimed to investigate the impact of EMDR therapy on fibromyalgia symptoms, depression, sleep quality, and traumatic stress in fibromyalgia patients through a randomized controlled study (RCT).Materials and methodsThe sample for this study comprised 79 individuals diagnosed with fibromyalgia. Participants were randomly assigned to two groups: the “Treatment as Usual” (TAU) group and the TAU + EMDR group. Prior to the study and at six different time points (before starting the study, at the end of the 5th, 10th, and 15th sessions, 1 month later, and 3 months later), participants completed assessments, including the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), Fibromyalgia ACR 2010 Diagnostic Criteria [Widespread Pain Index (WPI) and Symptom Severity Scale (SSS)], Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and Trauma Symptom Checklist-40 (TSC-40).ResultsThere were no differences in the sociodemographic variables between the study and experimental groups. Analysis of variance revealed a statistically significant group effect on VAS (p = 0.019), WPI (p = 0.018), BDI (p = 0.019), and TSC-40 (p = 0.21). After applying Bonferroni correction, EMDR was found to be effective for VAS, WPI, SSS, BDI, PSQI, and TSC-40 (p &lt;0.05).ConclusionThe results of the current study suggest that EMDR therapy is a viable alternative treatment for fibromyalgia. We believe these findings offer robust evidence supporting the efficacy of EMDR therapy in treating fibromyalgia, particularly in the context of a randomized controlled trial (RCT). The application of EMDR therapy for the treatment of patients with fibromyalgia is likely to be beneficial.Clinical trial registrationClinicalTrials.gov, identifier NCT06265194.
Coping strategies and adherence in people with mood disorder: a cross-sectional study
Authors: Jeżuchowska Alicja , Schneider-Matyka Daria , Rachubińska Kamila , Reginia Artur , Panczyk Mariusz , Ćwiek Dorota , Grochans Elżbieta , Cybulska Anna Maria 
Published: May 2024

IntroductionNon-adherence to treatment recommendations is a significant problem, as it contributes to the progression of the disease and to the exacerbation of distressing symptoms. Failure to cope with the disease and elevated levels of stress, in turn, influence the choice of strategy for coping with a difficult situation, and thus adherence to recommendations.ObjectivesThe purpose of our study was to evaluate the impact of the subjects’ stress coping styles on therapeutic adherence, life satisfaction, disease acceptance and quality of life (QoL) in people with mood disorders.MethodsThis survey-based study included 102 respondents diagnosed with mood disorders, living in the West Pomeranian Voivodeship. It was performed using the sociodemographic questionnaire and standardized tools: The Coping Inventory for Stressful Situations (CISS), The Satisfaction with Life Scale (SWLS), The Short Form-36 (SF-36) Health Survey, The Adherence to Refills and Medication Scale (ARMS), and The Acceptance of Illness Scale (AIS).ResultsSome 47.06% of the respondents suffered from depressive disorders, while 34.31% had depression or mixed anxiety disorder. Patients who made greater use of an emotion-focused style were found to have significantly lower life satisfaction than other patients. Moreover, this style was related to such SF-36 domains as general health, social functioning, role emotional, vitality, and mental health, as well as to physical component summary (PCS) and mental component summary (MCS).ConclusionTreatment non-adherence is a serious challenge in the treatment of patients with mood disorders. Individuals who do not adequately follow treatment recommendations often resort to alternative activities as a mechanism for coping with difficult situations. Patients who predominantly adopt an emotion-oriented coping style tend to experience lower life satisfaction and greater difficulty accepting their condition compared to their peers. Conversely, patients who adopt a task-oriented coping style report better quality of life than those who rely on emotion-oriented coping or alternative activities.
Lower back pain and associated factors among weavers working in Bahir Dar City, Northwest Ethiopia: A cross-sectional study
Authors: Zinabu Fiseha Sefiwu , Getie Kefale , Takele Mihret Dejen , Chanie Samuel Teferi , Abich Yohannes , Shibabaw Yadelew Yimer , Kibret Alemu Kassaw 
Published: May 2024

BackgroundWork-related musculoskeletal disorders are widespread among workers of informal small-scale enterprises. Specifically, lower back pain is a prevalent occupational health problem across various industries, including weaving factories. Lower back pain significantly impairs the functioning, performance, and productivity of weavers. However, information on the prevalence and associated factors of low back pain among weavers of Bahir Dar City and nationwide is scarce. Therefore, this study aimed to assess the prevalence and associated factors of lower back pain among weavers working in Bahir Dar City.MethodA multicentered institutional-based cross-sectional study was conducted on 403 weavers in Bahir Dar City, Ethiopia, from April to May 2023 using a structured face-to-face interview questionnaire. Samples were proportionally allocated to each institution, and study participants were selected using a simple random sampling technique. Variables with a P-value &lt; 0.25 in the bivariate logistic regression were adopted for the multivariate logistic regression analysis after verifying the model fitness. In the multivariate logistic regression analysis, the adjusted odds ratio (AOR) with a 95% confidence interval (CI) and a P-value &lt; 0.05 were considered to identify the associated factors of lower back pain among weavers.ResultThe results revealed that the overall annual prevalence of lower back pain was 63.5% (95% CI = 58.8–68.5). Longer working hours [AOR = 2.580 (CI = 1.517–4.384)], lack of back support [AOR = 1.938 (CI = 2.089–3.449)], repetitive movement of the back during weaving [AOR = 5.940 (CI = 2.709–13.02)], awkward posture [AOR = 2.915 (CI = 1.677–5.065), static working posture [AOR = 4.505 (CI = 2.298–8.831)], and job stress [AOR = 3.306 (CI = 1.896–5.765)] were significantly associated with lower back pain among weavers.ConclusionsLower back pain among weavers was found to be highly prevalent. Working longer hours, lack of back support, repetitive movement of the back, awkward posture, static posture, and job stress were significantly associated with lower back among weavers. The study recommends prompt interventions on weavers to ensure that they use sitting support, weave for &lt;8 h per day, change positions every 2 h, reduce job-related stress, and minimize task repetition, thereby enhancing their working conditions and minimizing the occurrence of lower back pain.
Evaluating the effects of two different kinesiology taping techniques on shoulder range of motion and proprioception in patients with hypermobile Ehlers–Danlos syndrome: a randomized controlled trial
Authors: Tudini Frank , Jordon Max , Levine David , Healy Michael , Cathey Sarah , Chui Kevin 
Published: May 2024

BackgroundEhlers–Danlos syndrome (EDS) is a common group of inherited connective tissue disorders with a prevalence as high as 0.75%–2% of the population. Physical manifestations include pain and decreased proprioception, especially in more mobile joints, such as the shoulder. The kinesiology tape (K-Tape) is often used to treat patients with shoulder dysfunction. The effectiveness of the K-Tape is uncertain, and there is a lack of studies specifically studying the K-Tape in an EDS population.PurposeThe purpose of this study was to compare the short-term effects of two different K-Tape procedures on shoulder active joint reposition (AJR) and active range of motion (AROM) in patients with hypermobile EDS (hEDS) and shoulder pain.MethodsAll participants were recruited from the EDS support groups and presented with shoulder pain. Baseline demographic information was obtained for each participant, after which AROM and AJR were assessed. The participants were randomized to receive one of two K-Tape procedures. Testing was repeated immediately post-taping and 48 h post-taping.ResultsSignificant improvements in shoulder external (F = 10.917, p &lt; 0.001) and internal (F = 11.736, p &lt; 0.001) rotations were seen from baseline to immediately post-taping and baseline to 48 h post-taping in the experimental K-Tape group. There were no significant differences in the shoulder rotation in the control K-Tape group and no significant differences in either group for shoulder flexion or AJR at any time point (p &gt; 0.05).ConclusionK-Tape may offer short-term improvements in shoulder rotation AROM in patients with hEDS and shoulder pain.
Midterm survival and risk factor analysis in patients with pyogenic vertebral osteomyelitis: a retrospective study of 155 cases
Authors: Schindler Melanie , Walter Nike , Reinhard Jan , Pagano Stefano , Szymski Dominik , Alt Volker , Rupp Markus , Lang Siegmund 
Published: May 2024

BackgroundPyogenic vertebral osteomyelitis (VO) represents a clinical challenge and is linked to substantial morbidity and mortality. This study aimed to examine mortality as well as potential risk factors contributing to in-hospital mortality among patients with VO.MethodsThis retrospective analysis involved patients receiving treatment for VO at University Regensburg in Germany from January 1, 2000, to December 3, 2020. It included in-hospital mortality rate, comorbidities and pathogens. Patients were identified using ICD-10 diagnosis codes: M46.2, M46.3, M46.4, and M46.5. Kaplan–Meier probability plots and odds ratios (OR) for mortality were calculated.ResultsOut of the total cohort of 155 patients with VO, 53 patients (34.1%) died during a mean follow-up time of 87.8 ± 70.8 months. The overall mortality was 17.2% at one year, 19.9% at two years and 28.3% at five years. Patients with congestive heart failure (p = 0.005), renal disease (p &lt; 0.001), symptoms of paraplegia (p = 0.029), and sepsis (p = 0.006) demonstrated significantly higher overall mortality rates. In 56.1% of cases, pathogens were identified, with Staphylococcus aureus (S. aureus) and other unidentified pathogens being the most common. Renal disease (OR 1.85) and congestive heart failure (OR 1.52) were identified as significant risk factors.ConclusionEarly assessment of the specific risk factors for each patient may prove beneficial in the management and treatment of VO to reduce the risk of mortality. These findings demonstrate the importance of close monitoring of VO patients with underlying chronic organ disease and early identification and treatment of sepsis. Prioritizing identification of the exact pathogens and antibiotic sensitivity testing can improve outcomes for patients in this high-risk group.
Minimizing Incision in Living Donor Liver Transplantation: Initial Experience and Comparative Analysis of Upper Midline Incision in 115 Recipients
Authors: Rastogi Amit , Gupta Ankur A. , Bansal Raghav , Kollanta Valappil Fysal , Yadav Kamal S. , Chaudhary Suchet , Bhangui Prashant , Dhampalvar Swapnil , Choudhary Narendra S. , Saraf Neeraj , Soin Arvinder S. 
Published: May 2024

Living donor liver transplantation (LDLT) needs “Mercedes Benz” or “J-shaped” incision, causing short and long-term complications. An upper midline incision (UMI) is less invasive alternative but technically challenging. Reporting UMI for recipients in LDLT vs. conventional J-shaped incision. Retrospective analysis, July 2021 to December 2022. Peri-operative details and post-transplant outcomes of 115 consecutive adult LDLT recipients transplanted with UMI compared with 140 recipients with J-shaped incision. Cohorts had similar preoperative and intraoperative variables. The UMI group had significant shorter time to ambulation (3 ± 1.6 vs. 3.6 ± 1.3 days, p = 0.001), ICU stay (3.8 ± 1.3 vs. 4.4 ± 1.5 days, p = 0.001), but a similar hospital stay (15.6±7.6 vs. 16.1±10.9 days, p = 0.677), lower incidence of pleural effusion (11.3% vs. 27.1% p = 0.002), and post-operative ileus (1.7% vs. 9.3% p = 0.011). The rates of graft dysfunction (4.3% vs. 8.5% p = 0.412), biliary complications (6.1% vs. 12.1% p = 0.099), 90-day mortality (7.8% vs. 12.1% p = 0.598) were similar. UMI-LDLT afforded benefits such as reduced pleuropulmonary complications, better early post-operative recovery and reduction in scar-related complaints in the medium-term. This is a safe, non-inferior and reproducible technique for LDLT.
EFEITOS DO HIPOTIREOIDISMO CONGÊNITO NO DESENVOLVIMENTO CEREBRAL: IMPACTO NA COGNIÇÃO, COMPORTAMENTO E DESENVOLVIMENTO PSICOMOTOR.
Authors: Brito Paulo Roberto da Silva , Veras Marina Andrade de Lobão , Gomes Ferlany Araujo Carneiro , Brandão Regislene Bomfim de Almeida , Caixeta Maria Carolina Martins , Araújo Izabela Luiza Guimarães , Brito Nayla Cristine da Silva , Silva Rafaela Mendes , Paixão Rafaella Keila Moreira , Alves Dayara Hellen Sousa , Caixêta Pedro Henrique Martins , Santiago Larissa de Paula 
Published: May 2024

O hipotireoidismo congênito é uma condição endócrina caracterizada pela deficiência parcial ou total dos hormônios tireoidianos ao nascer. Esses hormônios desempenham um papel crucial no desenvolvimento do sistema nervoso central. A falta desses hormônios pode levar a distúrbios neurológicos e cognitivos. O hipotireoidismo congênito não tratado está associado a déficits cognitivos, problemas de aprendizagem, memória, atenção, habilidades linguísticas e comportamentais. Metodologia: A pesquisa foi realizada através do acesso online nas bases de dados científicos como: Google Scholar, National Library of Medicine(PubMed), Biblioteca Virtual em Saúde (BVS) e Scientific Electronic Library Online(SCIELO) para seleção dos artigos, através de palavras-chave presentes nos descritores Cognição, Comportamento, Desenvolvimento Cerebral, Desenvolvimento Psicomotor, Hipotireoidismo Congênito, Intervenção Precoce, Terapia de Reposição Hormonal, Triagem Neonatal. Resultados: A pesquisa enfatiza a relação entre o início tardio do tratamento e deficiências cognitivas, comportamentais e psicomotoras significativas, destacando a importância da triagem neonatal e da intervenção imediata. Além disso, aponta uma janela crítica para o tratamento nas primeiras semanas de vida, quando o cérebro está em desenvolvimento acelerado e sensível à deficiência hormonal. Também destaca a influência dos hormônios tireoidianos no comportamento, emoções e desenvolvimento motor, com a necessidade de terapia de reposição hormonal precoce e acompanhamento multidisciplinar. Considerações Finais: O hipotireoidismo congênito é uma condição séria que precisa de uma equipe de diferentes especialistas para garantir o melhor resultado possível para as crianças afetadas.