bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIFFICULTIES OF DIAGNOSIS AND RESULTS OF SURGICAL TREATMENT OF ECHINOCOCCOSIS OF THE LIVER AND LUNGS
Authors: Котельникова Л.П. , Плаксин С.А. 
Published: May 2024

Цель - изучить сложности диагностики эхинококкоза печени и легких, оценить результаты хирургического лечения. Материалы и методы. Оперировано 47 пациентов с эхинококкозом печени и легких, у 31 из них был диагностирован эхинококкоз печени, у 9 печени и легких и у 7 – только легких. Всем пациентам выполнена КТ органов грудной и брюшной полостей с болюсным усилением. В оперативном лечении использовали как традиционные «открытые доступы» (80,85%), так и мини-инвазивные (19,15%). Изучены ближайшие результаты хирургического лечения. Результаты. Чувствительность КТ для диагностики эхинококковых кист печени составила 93,02%, для диагностики паразитарного поражения легких - 80%. В послеоперационном периоде в семи случаях развились осложнения (11,48%). Заключение. Чувствительность КТ в диагностике эхинококкоза печени выше, чем легких. Статистически значимой разницы в количестве послеоперационных осложнений в зависимости от хирургического доступа («открытые» операции или мини-инвазивные) не обнаружено.
The aim is to study the difficulties of diagnosing echinococcosis of the liver and lungs, to evaluate the results of surgical treatment. Materials and methods. 47 patients with echinococcosis of the liver and lungs were operated on, 31 of them were diagnosed with echinococcosis of the liver, 9 - of the liver and lungs and 7 - of the lungs only. All patients underwent CT of the thoracic and abdominal cavities with bolus amplification. In surgical treatment, both traditional "open access" (80.85%) and mini-invasive (19.15%) were used. The immediate results of surgical treatment have been studied. Results. CT sensitivity for the diagnosis of echinococcal liver cysts was 93.02%, for the diagnosis of parasitic lung lesions - 80%. In the postoperative period, complications developed in seven cases (11.48%). Conclusion. CT sensitivity in the diagnosis of echinococcosis of the liver is higher than that of the lungs. There was no statistically significant difference in the number of postoperative complications depending on surgical access ("open" operations or mini-invasive).
Overcoming Immune Evasion in CAR-T Cell Therapy: Mechanisms and Coping Strategies for Clonal Evolution in Multiple Myeloma
Authors: Li Hua , Zhu Benben 
Published: May 2024

This paper addresses the issue of immune evasion in CAR-T cell therapy, exploring the mechanisms underlying clonal evolution in multiple myeloma and proposing corresponding coping strategies. Overcoming these challenges necessitates a comprehensive approach, incorporating alternative therapeutic modalities and the advancement of next-generation CAR-T cell therapy. Furthermore, prioritizing in-depth investigations into drug resistance and immune evasion mechanisms, tailoring treatment strategies to individual patients, and conducting clinical trials and regulatory initiatives emerge as key focal points for future research. These endeavors are anticipated to propel the advancement of CAR-T cell therapy in multiple myeloma, offering enhanced treatment prospects for patients.
Upaya pembinaan warga gereja kelompok usia anak-anak menurut Alkitab
Authors: Setiawan David Eko , Gulo Icha Debora , Alvionita Gita Maisa , Suberti Valencia Sirut 
Published: May 2024

AbstractDuring childhood, children may not be able to manage information properly. Children's desires are often instant, causing them to do things that are not right. Therefore, it is the responsibility of the Church Community Development to teach the children according to the teachings of the Bible in the church. Therefore, the church's development efforts focus on children to achieve the main goal of teaching or educating each age group of children to reach a level of growth that is in line with the fullness of Jesus according to the Bible. Therefore, the church's development efforts for children need to be carefully designed and structured according to Christian values and biblical teachings. The author uses a qualitative descriptive analysis research method based on literature, which collects data through journals and books. The purpose of this writing is to clarify the role of church community development in shaping the character of Sunday school children in accordance with the teachings of the Bible. Key words: The upbuilding of church citizens, children, and the biblical AbstrakPada masa Anak-anak belum dapat mengelola informasi dengan baik. Keinginan anak-anak adalah sesuatu yang instan sehingga hal yang tidak benar pun akan mereka lakukan. Hal ini merupakan tanggung jawab Pembinaan Warga Gereja kepada kelompok anak untuk mengajarkan sesuai dengan ajaran Alkitab didalam gereja. oleh sebab itu upaya pembinaan gereja memusatkan pembinaan kepada anak untuk mencapai tujuan utama yaitu mengajarkan atau mendidik setiap kelompok usia anak-anak mencapai tingkat pertumbuhan yang sesuai dengan kepenuhan Yesus menurut Alkitab. Oleh sebab itu, upaya pembinaan gereja kepada kelompok usia anak perlu dirancang dengan matang dan disusun sesuai nilai-nilai kekristenan dan ajaran Alkitab. Penulis menggunakan metode penelitian analisis dekriftif kualitatif yang berbasis kepustakaan yang dimana metode ini mengumpulkan data yang ada melalui jurnal dan buku. Ada pun Tujuan dari penulisan memperjelas peran pembinaan warga gereja dalam membentuk karakter anak sekolah minggu sesuai dengan ajaran Alkitab. Kata kunci: Pembinaan Warga Gereja, Anak. Alkitabiah
A Literature Review on Karabakh Women Poets of the 19th Century
Authors: Memmedhuseynova Zulfiyye 
Published: May 2024

The 19th century was the beginning of a period in the history of Azerbaijan in which new views, different approaches, and judgments emerged. The upheavals in social life as a matter, of course, led to the awakening of literary and artistic thoughts, and enlightenment, and elucidated the development of public, ethnic, and national identity. In the 19th century, the poetic assemblies functioning in Karabakh contributed to the development of literature, especially poetry, and the inclusion of poetry in social life and its impact on it. Thanks to the "Meclis-i Uns" and "Meclis-i Feramushan" literary assemblies, poets living in Karabakh came together and depicted the problems of the period, social life, and nature in their poems. Referring to these literary samples, it is feasible to see the view of 19th-century Karabakh. Aghabeyim Agha, Khurshidbanu Natavan, Fatma Khanim Kamina, and Ashuq Peri were female poets grown up in the Karabakh literary environment in the 19th century. Research related to the life, art, and literary personality of women poets who grew up in Karabakh was thoroughly scrutinized and investigated based on the qualitative method in the article. As a result of our research, we have come to the following conclusions; There is a need to prepare coherent comparative texts from the work of female poets. The works of these poets were published due to the permission of Soviet censorship. Poems with religious content were not included in these books, and Sufi works were presented as secular and divine poems.
Keywords: Karabakh, Enlightenment, Poet, Literary Heritage, Azerbaijan.
T, Hılvet
Authors: Atay Öner 
Published: May 2024

Bu çeviri, Şura dergisinde T. kısaltmasıyla Hılvet başlığıyla yayınlanan yazıdan oluşmaktadır. Ramiyev / Ramioğulları olarak bilinen iki kardeş tarafından yayınlanan Şura dergisi, 15 Gınvar 1908 yılında onbeş günde bir olmak üzere Rıza Fahruddin’in muharrirliğinde yayın hayatına başladı ve 1918 yılında kapatıldı. Vakit ve Şura dergisi çevresi, Cedid hareketi içerisinde yer almaktadır. Bundan dolayı da Şura dergisinde yayınlanan yazılar, Cedid harekitinin fikir, faaliyet ve çabaları etrafında şekillenmiştir. Müslümanlar ve özellikle Türk dünyasının fikri faaliyetlerine yönelik araştırma aynı zamanda güncel durumun tespitine yönelerek yenileşmeyi aktarmaktadır. Hılvet başlığı altında ele alınan makale, Türkistan’a giden yazarın gezi, gözlem ve görüşmeleri etrafında şekillenmiştir. Buna göre Ahmet Yesevi, mescidi, türbesi, hocalar, dervişler ve ziyaretçilere yönelik gözlem ve görüşmeye dayalı bilgi sunmaktadır.
Anahtar Kelimeler: Ahmet Yesevi, Hılvet, Şura.
Análisis comparativo entre el aprendizaje de matemáticas, presencial y virtual en las instituciones de educación
Authors: Bastidas Logroño Diego Javier , Morales Tufiño Karina Gabriela , Vargas Sinmaleza Gloria Raquel , Elizalde Sarango Darwin Benito 
Published: May 2024

Este estudio se presenta con el fin de realizar un pequeño análisis comparativo en la enseñanza de las matemáticas presencial y virtual, éste estudio parte del paradigma interpretativo ya que permite comprender los problemas existentes en la sociedad actual, la relación de este estudio es analizar a través de una investigación comparada sobre los efectos del aprendizaje virtual y presencial de matemáticas. El estudio de las matemáticas es importante porque incide en la formación de las personas para contribuir a la sociedad, es por eso que los estudiantes deben obtener un aprendizaje significativo, para ello, sistemas de aprendizaje tanto virtual como presencial necesitan brindar una enseñanza adecuada. Este estudio busca el concepto de enfoques teóricos de la enseñanza y el aprendizaje de las matemáticas apoyadas en entornos virtuales en el contexto de la educación universitaria, en el que se muestra que los docentes sienten la necesidad de cambiar los métodos de enseñanza de las matemáticas, especialmente las estrategias y métodos de aprendizaje. Los recursos para producir un aprendizaje más significativo y mejorar el desarrollo cognitivo, lógico y matemático. La investigación adopta un paradigma cualitativo. Bajo el método etnográfico, las etapas de trabajo son la selección de temas, el trabajo de campo, el análisis de la información y la construcción del producto.
USP22 as a key regulator of glycolysis pathway in osteosarcoma: insights from bioinformatics and experimental approaches
Authors: Zhang Qiao , Zhu Jinwei , Xie Jian , Gu Yurong , Chen Lu 
Published: May 2024

Background
Osteosarcoma is the most common primary malignant bone tumor, but its pathogenesis remains unclear. Ubiquitin-specific processing peptidase 22 (USP22) is reported to be highly expressed and associated with tumor malignancy and prognosis in cancers. However, the role and mechanism of USP22 in osteosarcoma is not fully understood. This study aims to investigate the function and potential mechanism of USP22 in osteosarcoma using bioinformatics analysis combined with experimental validation.

Methods
We first integrated transcriptomic datasets and clinical information of osteosarcoma from GEO and TCGA databases to assess the expression and prognostic value of USP22 in osteosarcoma. Then, differential expression analysis and weighted gene co-expression network analysis (WGCNA) were conducted to identify USP22-related co-expressed genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to explore the biological functions and signaling pathways of USP22 co-expressed genes. To validate the accuracy of bioinformatics analyses, we downregulated USP22 expression in osteosarcoma cell line Sao-2 using siRNA and assessed its effect on cell proliferation, migration, invasion, apoptosis, and regulation of key signaling pathways.

Results
We found that USP22 was highly expressed in osteosarcoma tissues and correlated with poor prognosis in osteosarcoma patients. USP22 also showed potential as a diagnostic marker for osteosarcoma. In addition, 344 USP22-related co-expressed genes were identified, mainly involved in signaling pathways such as glycolysis, oxidative phosphorylation, spliceosome, thermogenesis, and cell cycle. The in vitro experiments confirmed the accuracy and reliability of bioinformatics analyses. We found that downregulation of USP22 could inhibit Sao-2 cell proliferation, migration, invasion, and induce apoptosis. Furthermore, downregulation of USP22 significantly reduced aerobic glycolysis levels in Sao-2 cells and inhibited the expression of key enzymes and transporters in aerobic glycolysis pathways such as HK2, PKM2, and GLUT1.

Conclusions
USP22 plays a critical role in the occurrence, development, and prognosis of osteosarcoma. USP22 could influence Sao-2 cell proliferation, apoptosis, migration, and invasion by regulating the glycolysis pathway, thereby promoting osteosarcoma progression. Therefore, USP22 may be a potential therapeutic target for the treatment of osteosarcoma.
The first observation of 1J(SnC) coupling constants in tin–carbon double‐bond compounds
Authors: Mizuhata Yoshiyuki , Tokitoh Norihiro 
Published: November 2010

AbstractThe 1J(SnC)s in the tin–carbon double‐bond systems were determined for the first time. These results were supported by theoretical calculations, showing the high s‐character of the SnC double bonds. The new findings obtained will be of great use in the development of tin‐containing functionalized materials. Copyright © 2010 John Wiley & Sons, Ltd.
Novel low‐dielectric‐constant copolyimide thin films composed with SiO2 hollow spheres
Authors: Yuan Yuan , Lin Bao‐Ping , Sun Yue‐ming 
Published: November 2010

AbstractA series of copolyimide/SiO2 hollow sphere thin films were prepared successfully based on bis[3,5‐dimethyl‐4‐(4‐aminophenoxy)phenyl]methane and 9,9‐bis(4‐(4‐aminophenoxy)phenyl)fluorene (molar ratio = 3 : 1) as diamine, and 4,4′‐(4,4′‐isopropylidenediphenoxy)bis(phthalic anhydride) as dianhydride, with different wt % SiO2 hollow sphere powder with particle size 500 nm. Some films possessed excellent dielectric properties, with ultralow dielectric constants of 1.8 at 1 MHz. The structures and properties of the thin films were measured with Fourier transform infrared spectra, scanning electron microscope, thermogravimetric analysis, and dynamic mechanical thermal analysis. The polyimide (PI) films exhibited glass‐transition temperatures in the range of 209– 273°C and possessed initial thermal decomposition temperature reaching up to 413–477°C in air and 418–472°C in nitrogen. Meanwhile, the composite films were also exhibited good mechanical properties. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Solid State Electrochemical Study of Oxygen Nonstoichiometry and Transport in Superconducting Ceramics
Authors: Schoch B. , Weppner W. 
Published: November 2010

AbstractZirconia based solid oxygen ion conductors were employed to control the oxygen content and activity of YBa2Cu3O6+x at elevated temperatures at which the material is commonly prepared and the superconducting properties are adjusted. Experimental problems of the reactivity between the electrolyte and the sample and the exchange of oxygen with the surrounding gas phase due to the high oxygen equilibrium partial pressure became eliminated. The lowest oxygen concentration appears at the composition YBa2Cu3O6 which corresponds at the same time to the ideal stoichiometry. The oxygen activity increases rapidly for small oxygen excess concentrations and turns finally into a very slow increase at large stoichiometric deviations; this is related to a semiconductor‐metal transition. The maximum oxygen concentration is limited to 60% of the structurally expected amount. The Wagner factor drops from nearly 200 at ideal stoichiometry to a value close to 1 at large oxygen excess indicating the increasing role of screening effects by large hole concentrations which are generated to compensate the negative charge of the oxygen ions. Accordingly, the chemical diffusion coefficient of YBa2Cu3O6%plus;x drops rapidly with increasing deviation from the ideal stoichiometry from about to 10−9.8 to 10−12.3 cm2 at 700°C. The diffusivity is less stoichiometry dependent, but still decreases with increasing oxygen content. The partial ionic (minority) conductivity is several orders of magnitude lower than in ceramic solid electrolytes.
Focused Directed Evolution of Pentaerythritol Tetranitrate Reductase by Using Automated Anaerobic Kinetic Screening of Site‐Saturated Libraries
Authors: Hulley Martyn E. , Toogood Helen S. , Fryszkowska Anna , Mansell David , Stephens Gill M. , Gardiner John M. , Scrutton Nigel S. 
Published: November 2010

AbstractThis work describes the development of an automated robotic platform for the rapid screening of enzyme variants generated from directed evolution studies of pentraerythritol tetranitrate (PETN) reductase, a target for industrial biocatalysis. By using a 96‐well format, near pure enzyme was recovered and was suitable for high throughput kinetic assays; this enabled rapid screening for improved and new activities from libraries of enzyme variants. Initial characterisation of several single site‐saturation libraries targeted at active site residues of PETN reductase, are described. Two mutants (T26S and W102F) were shown to have switched in substrate enantiopreference against substrates (E)‐2‐aryl‐1‐nitropropene and α‐methyl‐trans‐cinnamaldehyde, respectively, with an increase in ee (62 % (R) for W102F). In addition, the detection of mutants with weak activity against α,β‐unsaturated carboxylic acid substrates showed progress in the expansion of the substrate range of PETN reductase. These methods can readily be adapted for rapid evolution of enzyme variants with other oxidoreductase enzymes.
Catalyst Characterization with O2‐TPD, N2 ‐,Kr‐sorption and SEM Using the Example of the Epoxidation of 1,3‐Butadiene
Authors: Otto T. N. , Dinjus E. , Hagen V. , Puls A. 
Published: November 2010

AbstractDie temperaturprogrammierte O2‐Desorption (O2‐TPD), die N2‐ und Kr‐ Gassorption sowie die Raster‐Elektronen‐Mikroskopie (REM) sind bedeutende Analysemethoden in der Katalysechemie. Am Beispiel eines korund‐ und eines calciumhexaaluminathaltigen Trägermaterials werden die Methoden angewendet und das Potenzial der eingesetzten Katalysatoren hinsichtlich der Oberflächeneigenschaften und der damit verbundenen Aktivität aufgezeigt. Welches der beiden geträgerten Katalysatorsysteme für die Ag‐katalysierte Epoxidierung von 1,3‐Butadien zu 3,4‐Epoxy‐1‐buten vorteilhafter ist, wird im Rohrreaktor getestet.
Fitting Solid Sponges into a Reactor Tube Concerning the Partial Oxidation of o‐Xylene as an Example
Authors: Mülheims Philip , Marz Stefan , Müller Steffen Peter , Kraushaar‐Czarnetzki Bettina 
Published: November 2010

AbstractDer Einsatz fester, offenporiger Schwämme in verfahrenstechnischen Anwendungen verspricht viele Vorteile. Bedingt durch ihre Struktureigenschaften weisen sie einen geringen Druckverlust und einen verbesserten Wärme‐ und Stofftransport im Vergleich zu herkömmlichen Partikelschüttungen auf. So wurde in den vergangenen Jahren in zahlreichen Studien das Potenzial dieser neuen Struktur aufgezeigt. In den wenigsten Veröffentlichungen wird jedoch auf die Art der Einpassung fester Schwämme in ihre Umgebung eingegangen. Im Rahmen dieser Arbeit wird anhand des Einsatzes keramischer Schwämme als Katalysatorträger in der partiellen Oxidation von o‐Xylol gezeigt, welche Bedeutung die Einpassung in Bezug auf das Prozess‐, das Umsatzverhalten und den Wärmetransport hat.
Stochastic model for living radical polymerisation of styrene initiated by epoxide radical ring opening
Authors: Al‐Harthi Mamdouh 
Published: November 2010

AbstractA stochastic model was developed to simulate the polymerisation kinetics and the detailed microstructure of the resulting polymers made by the living radical polymerisation of styrene initiated by epoxide radical ring opening. The model was used to predict monomer conversion, average molecular weight, polydispersity index, and molecular weight distribution as a function of polymerisation time. Simulations were used to explore the effects of rate constant values on chain microstructures and polymer properties and validated with experimental data published in the literature. It was found that some parameters, such as the exchange rate constant, have no significant effect on the polymerisation kinetics, whereas major effects were observed when other rate constants, such as the reduction rate constant, were changed.
Crystallization‐Driven Asymmetric Synthesis of Pyridine‐β‐nitroalcohols via Discovery‐Oriented Self‐Resolution of a Dynamic System (Eur. J. Org. Chem. 33/2010)
Authors: Angelin Marcus , Vongvilai Pornrapee , Fischer Andreas , Ramström Olof 
Published: November 2010

AbstractThe cover picture shows how diastereoselective crystallization selects and amplifies a certain pyridine‐nitroalcohol from a dynamic system of chemical compounds (symbolized by puzzle pieces). This serendipitous finding demonstrates the potential of working with dynamic systems for discovery purposes in general and provides an effective asymmetric synthesis protocol for pyridine‐nitroalcohols in particular. Details are discussed in the Short Communication by O. Ramström et al. on p. 6315 ff.
Performance of La2–xSrxCo0.5Ni0.5O4±δ as an Oxygen Electrode for Solid Oxide Reversible Cells
Authors: Laguna‐Bercero M. A. , Kinadjan N. , Sayers R. , El Shinawi H. , Greaves C. , Skinner S. J. 
Published: November 2010

AbstractLa2 – xSrxCo0.5Ni0.5O4 ± δ (LSCN) is presented as a novel electrode for both solid oxide fuel cells (SOFCs) and solid oxide electrolysis cells (SOECs). LSCN/10Sc1CeSZ (scandia and ceria stabilised zirconia)/LSCN symmetrical cells were fabricated and characterised by AC impedance spectroscopy under different oxygen partial pressures at temperatures of up to 900 °C. At 850 °C polarisation resistances of 5.15 and 5.74 Ω cm2 were found applying air and oxygen, respectively. Electrolysis and fuel cell j–V experiments were also performed at temperatures between 700 and 850 °C using a LSCN/10Sc1CeSZ/Ni‐YSZ. Electrochemical results showed that the cell performs equally in both SOFC and SOEC modes. Detailed results in terms of performance are presented and discussed. LSCN is presented as a good candidate for both SOFC and SOEC. The similar performance obtained for j–V (current density–voltage) curves in electrolysis and fuel cell operation mode is thought to be related to the flexible oxygen non‐stoichiometry of the LSCN (K2NiF4‐type structure).