bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the association of prostate cancer‐specific anxiety with sexual function, depression and cancer aggressiveness in men 1 year following surgical treatment for localized prostate cancer
Authors: Tavlarides Andrea M. , Ames Steven C. , Diehl Nancy N. , Joseph Richard W. , Castle Erik P. , Thiel David D. , Broderick Gregory A. , Parker Alexander S. 
Published: August 2012

AbstractBackgroundCancer‐specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA is also associated with factors affecting quality of life. Herein, we examine the association of CSA with psychosocial factors and PCa aggressiveness in a cohort of men 1 year after prostatectomy for localized PCa.MethodsFrom our prospective PCa Registry, we identified 365 men who underwent prostatectomy for localized PCa who completed the Memorial Anxiety Scale for Prostate Cancer (MAX‐PC) and Expanded Prostate Cancer Index Composite at 1‐year follow‐up. We evaluated the association of scores on the MAX‐PC with demographics, clinicopathologic features, sexual function, and depression scores using Wilcoxon Rank Sum and Kendall's tau correlation tests.ResultsHigher scores on the MAX‐PC (i.e., higher anxiety) are associated with younger age (p < 0.01) and non‐Caucasian race (p < 0.01). Men with higher MAX‐PC scores also reported poor sexual satisfaction/function (p < 0.01) and increasing depressive symptoms (p < 0.01). Finally, although higher anxiety is associated with several pathologic features of aggressiveness (stage, positive margins, PSA at 1 year; all p‐values < 0.01), we noted several men with clinically indolent disease who reported significant anxiety.ConclusionsOur data suggest that higher levels of CSA are associated with poor sexual function and increased depressive symptoms 1 year after prostatectomy. Moreover, we noted demographic and pathologic features associated with higher CSA as well. If confirmed, our data support development of models to predict men at high risk of CSA following PCa surgery and targeted referral for additional counseling. Copyright © 2012 John Wiley & Sons, Ltd.
Psycho‐oncological care in certified cancer centres—a nationwide analysis in Germany
Authors: Singer Susanne , Dieng Sebastian , Wesselmann Simone 
Published: August 2012

AbstractBackgroundOver the last few years, a nationwide voluntary certification system for cancer centres has been established in Germany. To qualify for certification, cancer centres must provide psycho‐oncological care to every patient who needs it. The aim of this study was to find out how many patients have been treated by a psycho‐oncologist in the certified centres.MethodsAll cancer centres in Germany that were re‐certified in 2010 provided data documenting how many patients with primary cancer received at least 30 min of psycho‐oncological consultation in 2009.ResultsData from n = 456 certified cancer centres were available. In the centres, a total of 36 165 patients were seen by a psycho‐oncologist for at least 30 min, representing 37.3% of all patients in the centres. The highest percentage of patients who received psycho‐oncological care was found in breast cancer centres (66.7%), and the lowest in prostate cancer centres (6.8%). Half of the patients (50.0%) in gynaecological cancer centres, 37.7% in colon cancer centres and 25.4% in lung cancer centres received psycho‐oncological care.ConclusionsCompared with non‐certified centres, the proportion of patients receiving psycho‐oncological care in certified cancer centres has increased. Copyright © 2012 John Wiley & Sons, Ltd.
Lanthanide binding and IgG affinity construct: Potential applications in solution NMR, MRI, and luminescence microscopy
Authors: Barb Adam W. , Ho Tienhuei Grace , Flanagan‐Steet Heather , Prestegard James H. 
Published: August 2012

AbstractParamagnetic lanthanide ions when bound to proteins offer great potential for structural investigations that utilize solution nuclear magnetic resonance spectroscopy, magnetic resonance imaging, or optical microscopy. However, many proteins do not have native metal ion binding sites and engineering a chimeric protein to bind an ion while retaining affinity for a protein of interest represents a significant challenge. Here we report the characterization of an immunoglobulin G‐binding protein redesigned to include a lanthanide binding motif in place of a loop between two helices (Z‐L2LBT). It was shown to bind Tb3+ with 130 nM affinity. Ions such as Dy3+, Yb3+, and Ce3+ produce paramagnetic effects on NMR spectra and the utility of these effects is illustrated by their use in determining a structural model of the metal‐complexed Z‐L2LBT protein and a preliminary characterization of the dynamic distribution of IgG Fc glycan positions. Furthermore, this designed protein is demonstrated to be a novel IgG‐binding reagent for magnetic resonance imaging (Z‐L2LBT:Gd3+ complex) and luminescence microscopy (Z‐L2LBT: Tb3+ complex).
Evaluating autonomous ground‐robots
Authors: Finn Anthony , Jacoff Adam , Del Rose Mike , Kania Bob , Overholt Jim , Silva Udam , Bornstein Jon 
Published: August 2012

AbstractThe robotics community benefits from common test methods and metrics of performance to focus their research. As a result, many performance tests, competitions, demonstrations, and analyses have been devised to measure the autonomy, intelligence, and overall effectiveness of robots. These range from robot soccer (football) to measuring the performance of a robot in computer simulations. However, many resultant designs are narrowly focused oroptimized against the specific tasks under consideration. In the Multi‐Autonomous Ground‐robotic International Challenge (MAGIC) 2010, the need to transition the technology beyond the laboratory and into contexts for which it had not specifically been designed or tested meant that a performance evaluation scheme was needed that avoided domain‐specific tests. However, the scheme still had to retain the capacity to deliver an impartial, consistent, objective, and evidence‐based assessment that rewarded individual and multivehicle autonomy. It was also important to maximize the understanding and outcomes for technologists, sponsors, and potential usersgained through after‐action review. The need for real‐time, simultaneous, and continuous tracking of multiple interacting entities in an urban environment and over 250,000 square meters in real time compounded the complexity of the task. This paper describes the scheme used to progressively down‐select and finally rank the teams competing in this complex and “operationally realistic” challenge. © 2012 Wiley Periodicals, Inc.
High Risk of Biliary Fistula After Isolated Segment VIII Liver Resection
Authors: Dokmak Safi , Agostini Julie , Jacquin Alexandre , Cauchy François , Farges Olivier , Belghiti Jacques 
Published: August 2012

AbstractBackgroundFor tumors deeply located in segment VIII (S8), right hepatectomy (RH) often is thought to solve the issue of technical accessibility. Yet, the common existence of an associated underlying diseased liver raises the question of parenchymal‐sparing resection.MethodsFrom 2002 to 2011, 34 patients underwent isolated S8 resection, and their operative and postoperative characteristics were compared to 34 matched patients who underwent RH for lesions located in S8.ResultsIndications and preoperative characteristics were comparable between the two groups except for larger tumors in RH patients compared with S8 patients (48 vs. 40 mm; p = 0.001). Achieving S8 resection required significantly longer clamping time (45 vs. 37 min, p = 0.011), more additional biliostasis because of obvious biliary leak (65 vs. 18 %, p < 0.001), and subsequently increased application of sealant material (56 vs. 9 %, p < 0.001) compared with RH. The overall complication rate was similar between the two groups (59 vs. 62 %, p = 0.804), although a trend toward a higher rate of biliary fistula was observed in S8 patients (20 vs. 6 %, p = 0.07). Routine CT scan performed on postoperative day 7 found significantly more subphrenic collections in S8 patients compared with RH patients (53 vs. 9 %, p = 0.003). On pathological examination, surgical margin width was comparable between the two groups.ConclusionsAnatomical S8 resection remains a technically demanding procedure with an elevated risk of postoperative biliary fistula but allows achieving adequate carcinologic resection. Increasing consideration for parenchymal sparing resection should lead to favor this approach as a treatment of choice for small and medium‐sized tumors located in this segment.
Early Detection of Hypocalcemia After Total/Completion Thyroidectomy: Routinely Usable Algorithm Based on Serum Calcium Level
Authors: Lazard Diane S. , Godiris‐Petit Gaëlle , Wagner Isabelle , Sarfati Emile , Chabolle Frédéric 
Published: August 2012

AbstractBackgroundThe purpose of this prospective bicentric study was to investigate the course of serum calcium (Ca) and phosphorus (Phph) after total/completion thyroidectomy to establish a reliable and cost‐effective strategic algorithm to detect patients at risk for postoperative hypocalcemia.MethodsThis observational study included 136 patients. Serum Ca and Phph levels were preoperatively and postoperatively recorded 6, 12, 20, and 48 h (H) after skin closure. Criteria for hypocalcemia were postoperative Ca levels ≤1.9 mmol/L at any time point and/or patients experiencing symptoms of hypocalcemia. Postoperative Ca supplementation was never given before H20 assay. Ca levels and their differences between time points were compared.ResultsTwenty‐four percent of patients experienced hypocalcemia. At H12 and H20, the rates of patients with Ca levels ≤1.9 mmol/L were similar and larger than at H6 (p < 0.001). The H20‐preoperative difference had the best area under the ROC curves (value = 0.87), and a difference ≤−0.3 was significantly more frequent in case of hypocalcemia (p = 0.001). The H20 assay and the difference H20‐preop were consequently selected to design a new algorithm for hypocalcemia detection. Adding H48 assay in some specific cases (12.5 % of all included patients) enabled 100 % detection. Phosphorus assays were not informative in detecting hypocalcemia.ConclusionsThis new algorithm enables, with 100 % sensitivity and 88.4 % specificity, early detection of severe hypocalcemia after total/completion thyroidectomy. It may become a useful and cost‐effective tool for safe and early patient discharge, especially if PTH assays cannot be routinely used because of their availability or cost.
Robotic versus Conventional Laparoscopic Surgery for Rectal Cancer: A Cost Analysis from A Single Institute in Korea
Authors: Baek Se‐Jin , Kim Seon‐Hahn , Cho Jae‐Sung , Shin Jae‐Won , Kim Jin 
Published: August 2012

AbstractBackgroundSince its introduction, robotic surgery has been applied actively in several fields of minimally invasive surgery, and its use in the field of colorectal surgery is also increasing. In the studies to date, feasibility and safety have been the main focus, but the economics involved are important to examine. We compared the economics of robotic surgery with those of laparoscopic surgery for rectal cancer.Material and methodsWe analyzed the clinical characteristics, total hospital charges, payments, operating room costs, and hospital profits for patients who underwent robotic and laparoscopic resection of rectal cancer at Korea University Anam Hospital between July 2007 and August 2010.ResultsFrom July 2007 and August 2010, 154 robot‐assisted and 150 laparoscopic rectal surgeries were performed. The patient demographics were similar in the two groups with the exception of tumor location (6.7 vs 8.7 cm distal to the anal verge; p = 0.043), preoperative chemoradiotherapy (22.7 vs 8 %; p = 0.001), and operative time (285.2 vs 219.7 min; p = 0.018). Postoperative course and complications were also similar in the two groups. The total hospital charges in U.S. dollars ($14,647 vs $9,978; p = 0.001) and payments made by patients ($11,540 vs $3,956; p < 0.001) were significantly higher in the robotic group. Hospital profit was significantly lower in the robotic group than in the laparoscopic group ($689 vs $1,671; p < 0.001).ConclusionsRobot‐assisted surgery is more expensive than laparoscopic surgery for rectal cancer. Considering that robotic surgery can be applied more easily for low‐lying cancers, the cost‐effectiveness of robotic rectal cancer surgery should be assessed based on oncologic outcomes and functional results from future studies.
Pseudoaneurysm of the facial artery occurred after mandibular sagittal split ramus osteotomy
Authors: Jo H.-W. , Kim Y.-S. , Kang D.-H. , Lee S.-H. , Kwon T.-G. 
Published: August 2012

Abstract

Introduction
Pseudoaneurysms are caused by rupture of arteries with extravasation of blood. The compressed perivascular tissue forms the wall of aneurysmal sac. Pseudoaneurysm directly related with surgical procedure of sagittal split ramus osteotomy (SSRO) was reported quite rarely especially related with facial artery during the vertical osteotomy.

Case report
SSRO was carried out for a 19-year-old male; the patient visited the emergency room with notable swelling 3 weeks after the surgery. We experienced severe intra-oral bleeding with surgical exploration. Angiography revealed a pseudoaneurysm of the right facial artery that might be related with vertical osteotomy over lateral cortex of the mandibular body during orthognathic surgery. This implies that the minor vascular trauma from vertical osteotomy of the mandibular body during the conventional orthognathic surgery might cause later development of pseudoaneurysm.
Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child
Authors: Suárez‐Rodríguez Marta , Azcona‐San Julián Cristina , Alzina de Aguilar Valentín 
Published: August 2012

AbstractContextExperimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring.ObjectiveThe aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring.Materials and methodsThe study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities.Results54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual‐manipulative and memory coefficients.
No association between gain in body mass index across the life course and midlife cognitive function and cognitive reserve—The 1946 British birth cohort study
Authors: Albanese Emiliano , Hardy Rebecca , Wills Andrew , Kuh Diana , Guralnik Jack , Richards Marcus 
Published: August 2012

AbstractBackgroundThe association between lifelong body mass index (BMI) and cognitive function has not been comprehensively studied.MethodsIn more than 2000 men and women born in 1946, we tested associations between BMI gain at 15, 20, 26, 36, 43, and 53 years with respect to the previous measure (gain at age 15 years with respect to BMI at age 11 years), and semantic fluency (animal naming) and cognitive reserve (the National Adult Reading Test) at age 53 years, and verbal memory (word list recall) and speed/concentration (letter cancellation) at ages 43 and 53 years. Measures of BMI gain were adjusted in stages for childhood intelligence, education, socioeconomic position (SEP), lifestyle, and vascular risk factors.ResultsIndependent of childhood intelligence, BMI gain between ages 26 and 36 years was associated with lower memory scores (β per SD increase in BMI in men = −0.11; 95% confidence interval [CI]: −0.19, −0.02), verbal fluency (β in women = −0.11; 95% CI: −0.20, −0.02), and lower National Adult Reading Test score (β in women = −0.08; 95% CI: −0.15, −0.01), but not with speed/concentration (β in men = 0.02; 95% CI: −0.11, 0.07). Associations were largely explained by educational attainment and SEP (P ≥ .10). However, BMI gain at 53 years in men was independently associated with better memory (β = 0.12; 95% CI: 0.03, 0.22), and both underweight (β = −1.54; 95% CI: −2.52, −0.57) and obese (β = −0.30; 95% CI: −2.52, −0.57) women at 53 years had significantly lower memory scores.ConclusionThe adverse effect of higher BMI gain on midlife cognitive function and cognitive reserve is independent of childhood intelligence but not of education and SEP. The independent association between greater BMI gain in midlife and better cognitive function deserves further investigation.
Liver stiffness measurement in cirrhotic patient — Implications of disease activity and treatment efficacy
Authors: Xu Huang‐Wei , Lu Sheng‐Nan , Hung Chao‐Hung , Chang Kuo‐Chin , Hu Tsung‐Hui , Wang Jing‐Houng 
Published: August 2012

AbstractLiver stiffness measurement (LSM) is a noninvasive method for the diagnosis of hepatic fibrosis. The aim of this study was to evaluate the effects of hepatitis activity and antiviral therapy on LSM in cirrhotic patients. Consecutive patients with compensated hepatic cirrhosis were enrolled for LSM. The medical records of hepatitis activity and antiviral therapy before enrollment were reviewed. Patients were stratified into inactive, fluctuating, and active groups by serial change of alanine transaminase level. For chronic hepatitis C, patients were stratified into sustained virological response (SVR) and non‐SVR (NSVR) by effect of antiviral treatment. LSM results were compared among different groups. A total of 163 patients (mean age = 57.2 ± 11.0 years) were enrolled. The median (range) LSM values were 9.6 (4.2–20.6), 10.25 (3.9–49.6), and 15.75 (4.8–61.5) kPa in the inactive, fluctuating, and active groups, respectively. Patients in the active group had significantly higher LSM values. For chronic hepatitis C, median (range) LSM values were 16.6 (8.1–61.5), 22.9 (11.1–37.4), and 11.2 (3.9–27.0) kPa in patients without antiviral therapy, in NSVR, and in SVR groups, respectively. Patients with SVR had significantly lower LSM values. For chronic hepatitis B, median (range) LSM values were 11.8 (5.1–46.6), 16.85 (4.2–48), and 10.6 (4.3–46.4 kPa) kPa in patients without oral nucleos(t)ide analogue (NA) therapy, with NA < 12, and ≧12 months, respectively. There was a significantly lower LSM value in patients with NA therapy≧12 months. There were low LSM values in cirrhotic patients without hepatitis activity, as well as with SVR in chronic hepatitis C and long‐term NA therapy in chronic hepatitis B.
A UK and Irish survey of enteral nutrition practices in paediatric intensive care units
Authors: Tume Lyvonne , Carter Bernie , Latten Lynne 
Published: August 2012

The aim of the present study was to describe the present knowledge of healthcare professionals and the practices surrounding enteral feeding in the UK and Irish paediatric intensive care unit (PICU) and propose recommendations for practice and research. A cross-sectional (thirty-four item) survey was sent to all PICU listed in the Paediatric Intensive Care Audit Network (PICANET) database (http://www.picanet.org.uk) in November 2010. The overall PICU response rate was 90 % (27/30 PICU; 108 individual responses in total). The overall breakdown of the professional groups was 59 % nursing staff (most were children's nurses), 27 % medical staff, 13 % dietitians and 1 % physician assistants. Most units (96 %) had some written guidance (although brief and generic) on enteral nutrition (EN); 85 % of staff, across all professional groups (P= 0·672), thought that guidelines helped to improve energy delivery in the PICU. Factors contributing to reduced energy delivery included: fluid-restrictive policies (60 %), the child just being ‘too ill’ to feed (17 %), surgical post-operative orders (16 %), nursing staff being too slow in starting feeds (7 %), frequent procedures requiring fasting (7 %) and haemodynamic instability (7 %). What constituted an ‘acceptable’ level of gastric residual volume (GRV) varied markedly across respondents, but GRV featured prominently in the decision to both stop EN and to determine feed tolerance and was similar for all professional groups. There was considerable variation across respondents about which procedures required fasting and the duration of this fasting. The present survey has highlighted the variability of the present enteral feeding practices across the UK and Ireland, particularly with regard to the use of GRV and fasting for procedures. The present study highlights a number of recommendations for both practice and research.
Strange non-chaotic attractors in quasi-periodically forced circle maps: Diophantine forcing
Authors: JÄGER T. 
Published: August 2012

AbstractWe study parameter families of quasi-periodically forced (qpf) circle maps with Diophantine frequency. Under certain $\mathcal {C}^1$-open conditions concerning their geometry, we prove that these families exhibit non-uniformly hyperbolic behaviour, often referred to as the existence of strange non-chaotic attractors, on parameter sets of positive measure. This provides a nonlinear version of results by Young on quasi-periodic $\mathrm {SL}(2,\mathbb {R})$-cocycles and complements previous results in this direction which hold for sets of frequencies of positive measure, but did not allow for an explicit characterization of these frequencies. As an application, we study a qpf version of the Arnold circle map and show that the Arnold tongue corresponding to rotation number $1/2$collapses on an open set of parameters. The proof requires to perform a parameter exclusion with respect to some twist parameter and is based on the multiscale analysis of the dynamics on certain dynamically defined critical sets. A crucial ingredient is to obtain good control on the parameter dependence of the critical sets. Apart from the presented results, we believe that this step will be important for obtaining further information on the behaviour of parameter families like the qpf Arnold circle map.
Research on the SBS mediums used in high peak power laser system and their selection principle
Authors: Guo X.Y. , Hasi W.L.J. , Zhong Z.M. , Jin C.Y. , Lin D.Y. , He W.M. , Lu Z.W. 
Published: August 2012

AbstractIn this paper, we designed an experiment to research the properties for the stimulated Brillouin scattering (SBS) medium of perfluorocarbon-compounds (PFCs) and perfluoropolyether (PFPE), then we proposed that the selection principle of the high load capacity SBS medium can be used in the high peak power SBS system. The results showed that, for PFCs, perfluorinated hydrocarbons (FC-72) has the highest optical breakdown threshold (OBT); for PFPE, the medium with average molecular weight (AMW) less than 1000 has small medium absorption coefficient (AC) and high OBT, for AMW, greater than 1000, the medium AC becomes high and the OBT becomes low. Further research shows that, for PFPE series SBS medium, the AC increases and the OBT decreases gradually with increasing of AMW. We find some SBS mediums can work stably under high peak power pump, which lays a good foundation for the application of SBS technology in a high-power laser system.