bluuebunny/crossref_metadata_2025_split huggingface dataset:
Miss-Iology Meets Ms-Theology
Authors: Long Judi 
Published: January 2010

AbstractMissiology and feminist theology are becoming recognized as significant voices in contemporary Christian theology, both seeking to add other dimensions to the traditional elements of theology. Missiology seeks to bring mission back into the mainstream of Christian life and thought. While there is no one feminist theology but rather a diverse range of feminist theologies, these all seek to have the perspectives of women taken seriously in all aspects of theology. Both feminist theologies and missiology have areas that the other can critique. However, most importantly, they also have areas that can be enriched by engagement with each other. Missiology like much theology, has tended to be written by men, and focuses largely on the activities and priorities of men. It can benefit from the recognition of the role of women in mission both as missionaries, and as the missionised. Women have played a crucial role in mission that is only recently being recognized and affirmed. Feminist theologies have not tended to address issues of mission with the exception of the criticism of patriarchal missionary methods and their impact upon women. Missiology challenges feminist theologies to take seriously the core truths of the gospel and how these relate to world in which we live. The creative interaction between feminist theologies and missiology will have implications for our whole understanding of God, for our view of the Bible, and for how the gospel relates to a postmodern society. Both missiology and feminist theologies have challenges to bring to traditional theology. As they engage with each other, new and exciting aspects of both feminist theologies and missiology emerge that can be developed and explored.
Transforming Theological Education Through Experiential Learning in Urban Contexts
Authors: Hertig Paul 
Published: January 2010

AbstractAn important paradigm shift underway in education allows students to be partners in cooperative learning and to field test old answers to ever-changing problems in urban life through the continual journey into neighborhoods and the return journey into the classroom for reflection. The rhythm of journey in and journey out ofthe classroom allows spirituality, community and justice to embrace. Diversity is reflected through students' journeys into contexts where people's worldviews and faith suppositions differ from their own. Jesus educated his disciples by sending them out on journeys, sometimes going with them, other times processing their experiencesd when they returned. Students should likewise be allowed to journey outside the confines of the classroom and interact with the world in all of its complexities. Experiential learning in urban contexts calls for a "servant learner" approach rather than the "servant leader" approach that still dominates theological education. The servant learner goes into a context with the goal of understanding the culture, needs, agendas, and issues of a community as an alternative to the traditional method of seeking to set the agenda for the people of the community. Christian educators are called to slow down, reflect, re-evaluate, and re-direct the educational journey back from where it began-out in the world. In its commitment to free-floating thoughts and cognitive concepts, contemporary higher education is left unanchored and without concrete expression in the world. Theological education cannot justify itself based on what it has become, but must seek a new path based on what might become. It must return to its true calling of educating Christians in their faith journeys through engagement and participation in the real world. It must also allow those whom we serve in our communities to evaluate our efforts.
Religion, Conflict, and Reconciliation: Ecumenical Initiatives Amidst Human Brokenness and Community Division
Authors: Gort Jerald D. 
Published: January 2010

AbstractAfter reflecting on the ambiguous role of religion in terms of violence, Jerald D. Gort in this article outlines, first, the conditions for true reconciliation among peoples (acknowledgement of Christian complicity; no cheap reconciliation; no utopian enthusiasm; no fatalistic view of human capacity); then, second, he outlines the initiatives ofthe World Council of Churches (WCC) toward justice and reconciliation in the world. Such initiatives involve the struggle against injustice on the one hand and a practice of the "wider ecumenism" (dialogue of histories, theologies, spiritualities, and life) on the other.
"Identity" and Global Ethnic Violence
Authors: Payne Michael W. 
Published: January 2010

AbstractThis article explores the multidimensional nature of globalization as it impacts on "identity," both individually and corporately, in its most common manifestation as violence. Identity is explored in terms of the dialectical interplay between the "one" and the "many" or "universality" and "particularity" in order to offer an alternative reading of "identity" in light ofMiroslav Wolf's work Exclusion and Embrace. To do this the language of Paul in Galatians, and in other epistles as well, needs to be considered. Utilizing the insights of N. T. Wright and Richard Hays, the article then attempts to re-locate "identity" as constituted by our being new women and men in Christ. Also utilized is Paul Hiebert's analysis of set theory, which illustrates the necessity of moving away from "ssentialist" or "primordialist" readings of culture and identity in order to move toward more "centered set" thinking which is typical of Paul in Galatians. The article attempts to reorient Christians to a new way of thinking missiologically in light of the reality of violence and the need for broader notions of reconciliation and redemption.
Winti in Suriname
Authors: Vernooij Joop 
Published: January 2010

AbstractIn this contribution, long time missionary to Suriname, Joop Vemooij, presents an overview of Winti, a religion rooted in the complex culture of Surinam. After presenting a short history of the religion, Vernooij outlines some of its principal elements, and then presents a pastoral reflection on how Christians need to deal with practitioners of this religion in Surinam itself, and in the Netherlands, where some 300,000 Surinamese live today.
The Necessity and Limit of a Contextual Theology
Authors: Nessan Craig L. 
Published: January 2010

AbstractContextual theology is a necessity, but it also has limits. This is the thesis of Craig L. Nessan in this article. It is a necessity because of the Incarnation of Jesus Christ and the sacramental nature of Christian life. God is always revealed in particular times and places. Nevertheless, argues Nessan, contextual theology is limited by the consistency of God's character and activity. "While it is vital to pay attention to the particularity of God's revelation within a given context, it is equally necessary to affirm the coherence of God's characteristic way of becoming revealed." Careful reflection on the development of Christian doctrine demonstrates the value of attending both to its contextuality and its consistency. Doctrinal expression of faith provides the particularity of contextual expression (a certain language, culture, period) on the one hand, and provides the parameters of orthodoxy (the church's faith) on the other.
CHRIST CRUCIFIED: Lutheran Missiological Themes for a Post-Christian Century
Authors: Thomsen Mark 
Published: January 2010

AbstractDespite the fact that Lutheran theology is molded by the medieval theological context, argues Mark Thomsen in this article, its central reality of a theology of the cross offers a surprising "potential for constructing a dynamic foundation for a contemporary vison of the Missio Dei." What this theology of the cross is not is neither "a glorification of suffering and death," a simple repetition of the Anselmian doctrine of atonement, nor is it a doctrine of the atonement at all. Rather, a Lutheran theology of the cross is one with mission at the center. It means dying to oneself for the sake of the vision of the Reign of God. It means being in solidarity with the suffering peoples of the world. It means recognizing the almost overwhelming power of evil, and God's struggle in Christ with that power. Finally, a theology of the cross points to God's vulnerability in the world. Christians participate in God's mission by themselves taking up the cross, recognizing God's gracious commitment to offering abundant life to the entire creation.
Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation
Authors: Wadia Persis P. , Coram Marc , Armstrong Randall J. , Mindrinos Michael , Butte Atul J. , Miklos David B. 
Published: January 2010

Abstract
Identifying the targets of immune response after allogeneic hematopoietic cell transplantation (HCT) promises to provide relevant immune therapy candidate proteins. We used protein microarrays to serologically identify nucleolar and spindle-associated protein 1 (NuSAP1) and chromatin assembly factor 1, subunit B (p60; CHAF1b) as targets of new antibody responses that developed after allogeneic HCT. Western blots and enzyme-linked immunosorbent assays (ELISA) validated their post-HCT recognition and enabled ELISA testing of 120 other patients with various malignancies who underwent allo-HCT. CHAF1b-specific antibodies were predominantly detected in patients with acute myeloid leukemia (AML), whereas NuSAP1-specific antibodies were exclusively detected in patients with AML 1 year after transplantation (P < .001). Complete genomic exon sequencing failed to identify a nonsynonymous single nucleotide polymorphism (SNP) for NuSAP1 and CHAF1b between the donor and recipient cells. Expression profiles and reverse transcriptase–polymerase chain reaction (RT-PCR) showed NuSAP1 was predominately expressed in the bone marrow CD34+CD90+ hematopoietic stem cells, leukemic cell lines, and B lymphoblasts compared with other tissues or cells. Thus, NuSAP1 is recognized as an immunogenic antigen in 65% of patients with AML following allogeneic HCT and suggests a tumor antigen role.
Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice
Authors: Niwa Satoru , Urtz Nicole , Baumruker Thomas , Billich Andreas , Bornancin Frédéric 
Published: January 2010

AbstractCeramide kinase (CERK) produces the bioactive lipid ceramide-1-phosphate (C1P) and is a key regulator of ceramide and dihydroceramide levels. It is likely that CERK and C1P play a role in inflammatory processes but the cells involved and the mechanisms used remain to be clarified. In particular, the impact of CERK on T-cell biology has not been studied so far. Here, we usedCerk-/-mice backcrossed with DO11.10/RAG1-/-mice to probe the effect of CERK ablation on T-cell activation. Levels of interleukin (IL)-2, IL-4, IL-5, IL-13, of tumor necrosis factor (TNF)-α, and of interferon (INF)-γ were recorded following ovalbumin challenge in vivo and using ovalbumin-treated splenocytes ex- vivo. Absence of CERK led to a significant decrease in the production of IL-4, thus suggesting that CERK may polarize T cells towards the TH2 cell subtype. However, the importance of CERK to TH2 cell biology will have to be investigated further because in a model of asthma, which is TH2-cell driven,Cerk-/-mice responded like wild-type animals.
PREDICT: a new UK prognostic model that predicts survival following surgery for invasive breast cancer
Authors: Wishart Gordon C , Azzato Elizabeth M , Greenberg David C , Rashbass Jem , Kearins Olive , Lawrence Gill , Caldas Carlos , Pharoah Paul DP 
Published: January 2010

Abstract
Introduction
The aim of this study was to develop and validate a prognostication model to predict overall and breast cancer specific survival for women treated for early breast cancer in the UK.

Methods
Using the Eastern Cancer Registration and Information Centre (ECRIC) dataset, information was collated for 5,694 women who had surgery for invasive breast cancer in East Anglia from 1999 to 2003. Breast cancer mortality models for oestrogen receptor (ER) positive and ER negative tumours were derived from these data using Cox proportional hazards, adjusting for prognostic factors and mode of cancer detection (symptomatic versus screen-detected). An external dataset of 5,468 patients from the West Midlands Cancer Intelligence Unit (WMCIU) was used for validation.

Results
Differences in overall actual and predicted mortality were <1% at eight years for ECRIC (18.9% vs. 19.0%) and WMCIU (17.5% vs. 18.3%) with area under receiver-operator-characteristic curves (AUC) of 0.81 and 0.79 respectively. Differences in breast cancer specific actual and predicted mortality were <1% at eight years for ECRIC (12.9% vs. 13.5%) and <1.5% at eight years for WMCIU (12.2% vs. 13.6%) with AUC of 0.84 and 0.82 respectively. Model calibration was good for both ER positive and negative models although the ER positive model provided better discrimination (AUC 0.82) than ER negative (AUC 0.75).

Conclusions
We have developed a prognostication model for early breast cancer based on UK cancer registry data that predicts breast cancer survival following surgery for invasive breast cancer and includes mode of detection for the first time. The model is well calibrated, provides a high degree of discrimination and has been validated in a second UK patient cohort.
The adhesion mediated by the P-selectin P–selectin glycoprotein ligand-1 (PSGL-1) couple is stronger for shorter PSGL-1 variants
Authors: Barbaux Sandrine , Poirier Odette , Pincet Frédéric , Hermand Patricia , Tiret Laurence , Deterre Philippe 
Published: January 2010

AbstractDifferences in the adhesive properties of natural polymorphic variants of the P-selectin ligand are defined between intact and shorter PSGL variants.Interactions between P-sel and the PSGL-1 mediate the earliest adhesive events during an inflammatory response. Human PSGL-1 displays a high degree of genetic polymorphism that has been diversely associated with susceptibility to human diseases. In the central part of PSGL-1, a 10-aa motif is repeated 14, 15, or 16 times. Moreover, two mutations, M62I and M274V, are often found giving the most common variant M62–M274 with 16 motifs (M16M) and its variants I62–M274 (I16M). Two other variants exist with 15 repeated motifs (M62–M274; M15M) and with 14 motifs (M62–V274; M14V). We investigated the potential difference in the adhesive properties between these natural variants stably expressed in the HEK cell line by using the BFP technique. Their interactions with P-sel were found to be of catch bond-type, and the dissociation force was primarily dependent on the number of decameric motifs: the shorter the PSGL-1, the larger the bond strength. Finally, we found that the M62I mutation, which is close to the binding site to P-sel, reduced the adhesiveness to P-sel effectively. Collectively, these data shed new light on the polymorphism of PSGL-1 and could help the research on its associations to human pathologies.
Certolizumab Pegol: A TNF-α Antagonist for the Treatment of Moderate-to-Severe Crohn's Disease
Authors: Smith Lisa S , Nelson Michael , Dolder Christian R 
Published: January 2010

Objective:To review certolizumab pegol for the treatment of moderate-to-severe Crohn's disease (CD).Data Sources:Clinical studies were identified through MEDLINE (1966–October 1, 2009), bibliographies of articles, International Pharmaceutical Abstracts, clinicaltrials.gov, fda.gov, and New Drug Approval documents ( www.accessdata.fda.gov ). Search terms were CDP 870, certolizumab pegol, Cimzia, Crohn's disease, and inflammatory bowel disease.Study Selection and Data Extraction:Human studies describing pharmacology, pharmacokinetics, efficacy, and safety of certolizumab pegol were identified. Phase 2 and Phase 3 randomized controlled trials and observational studies were reviewed, with emphasis given to Phase 2 and Phase 3 trials.Data Synthesis:Certolizumab pegol is a tumor necrosis factor-alfa (TNF-α) antagonist, approved for the treatment of moderate-to-severe CD that is failing conventional therapy. It is an antigen-binding fragment (Fab') portion of an immunoglobulin G antibody attached to a polyethylene glycol moiety. In 2 Phase 3 randomized, placebo-controlled trials, certolizumab pegol was effective in inducing clinical response compared with placebo. Common adverse effects during clinical trials were upper respiratory tract infection, urinary tract infection, and arthralgia. Serious infection occurred in 3% of patients. The 4 published controlled trials for the use of certolizumab pegol in the treatment of CD share similar limitations with other studies of TNF-α antagonists including high placebo response, natural course of disease fluctuation, and the use of Crohn's Disease Activity Index to assess outcomes. However, certolizumab pegol is an effective agent for adults with moderate-to-severe CD with less than optimal response to conventional therapy. Long-term efficacy and safety data are unavailable. Certolizumab pegol and adalimumab, unlike infliximab, can be self-administered.Conclusions:With similarity in cost and the lack of head-to-head comparisons, patient and physician preference may determine choice of TNF-α antagonist.
Update on Pressure Ulcer Management and Deep Tissue Injury
Authors: Mao Cindy L , Rivet Amanda J , Sidora Tara , Pasko Mary T 
Published: January 2010

Objective: To review recent literature regarding therapeutic management of pressure ulcers and to discuss the potential implications of the newly recognized entity, deep tissue injury (DTI). Data Sources: A MEDLINE search was conducted of pressure ulcer therapy published between January 2001 and October 2009. Key search terms included pressure ulcers, deep tissue injury, nutrition, antibiotics, and therapy. Study Selection and Data Extraction: Comparative clinical trials involving pharmacologic agents in the treatment of pressure ulcers and DTI were evaluated. Included trials were those with defined interventions and outcome parameters for wound healing. Data Synthesis: Pressure ulcers remain an important issue in the care of elderly and immobilized patients. DTI has been recently added by the National Pressure Ulcer Advisory Panel as a separate category in the staging of pressure ulcers. There is currently a lack of consensus on how to identify and treat DTI. but preventive measures typically employed in the management of all pressure ulcers have been recommended. Recent studies on topical phenytoin, silver preparations, and growth factors report benefit in the management of pressure ulcers. However, studies evaluating these treatment approaches often lack the sample size necessary to adequately support recommendations. Conclusions: Determining the extent of tissue damage in DTI is currently not possible. Therefore, management recommendations focus on limiting extension of the ulcer stage through preventive strategies. Routine use of topical phenytoin, silver preparations, or growth factors in therapy of pressure ulcers cannot be recommended until more data from rigorously designed studies are available.
Safety of Subcutaneous Octreotide in Patients with Sulfonylurea-Induced Hypoglycemia and Congestive Heart Failure
Authors: Vallurupalli Srikanth 
Published: January 2010

Objective: To report the safe use of subcutaneous octreotide in the treatment of sulfonylurea-induced hypoglycemia in 2 patients with severe congestive heart failure. Case Summary: Two patients with congestive heart failure with systolic dysfunction presented with severe hypoglycemia (blood glucose level: patient 1, 31 mg/dL; patient 2, 36 mg/dL) secondary to sulfonylurea agents. The mechanism of hypoglycemia was poor oral intake and prolonged half-life of the drugs due to renal failure. Hypoglycemia was refractory to glucose supplementation. Patient 1 received 2 doses of octreotide 50 μg subcutaneously 12 hours apart, with resolution of hypoglycemia (blood glucose level: <33 mg/dL before administration of octreotide, 62 mg/dL after first dose, 121 mg/dL after second dose). Patient 2 received an initial dose of octreotide 25 μg subcutaneously; hypoglycemia persisted after this dose, and the patient was given 2 doses of 50 μg subcutaneously 12 hours apart, leading to resolution of hypoglycemia (blood glucose level: 57 mg/dL before administration of octreotide, 80 mg/dL after first dose, 85 mg/dL after second dose, 146 mg/dL after third dose). Resolution of hypoglycemia with octreotide treatment obviated the need for prolonged intravenous dextrose infusions. No local or systemic adverse effects, especially cardiac adverse events, were noted during the course of treatment. Discussion: Octreotide is considered the antidote for sulfonylurea-induced hypoglycemia. It may be especially useful in patients with congestive heart failure who may not tolerate intravenous infusions of dextrose. The package insert cautions of the occurrence of cardiac adverse effects such as bradycardia, heart block, and worsening heart failure. Patients with heart failure may theoretically be at a higher risk of these adverse effects due to the concurrent use of atrioventricular blocking agents. However, a review of current literature reveals that the adverse effect profile depends on the route, dose, and formulation of the octreotide used along with the clinical indication. These adverse effects may not be clinically significant with the doses used for treatment of sulfonylurea-induced hypoglycemia and the benefits of the drug may outweigh the risks. Conclusions: In these cases, octreotide was safely and effectively used in the treatment of sulfonylurea-induced hypoglycemia in patients with congestive heart failure by adhering to dosing guidelines and close monitoring.
Derolathrus cavernicolusn. sp., a Beetle Family New for North America (Coleoptera: Jacobsoniidae)
Authors: Peck Stewart B 
Published: January 2010

AbstractDerolathrus cavernicolus n. sp. is the first beetle in the family Jacobsoniidae described from continental North America. It is reported from cave and forested habitats in Florida, the island of Barbados in the Lesser Antilles, and tentatively from the island of Hawaii, USA. A key to the three known New World species of Derolathrus is provided. Derofathrus atomusSharp, 1908, of Hawaii is redescribed and new records are reported from Hawaii and the United States Virgin Islands. Derolathrus sharpiGrouvelle, 1912, of Guadeloupe (Lesser Antilles) is redescribed and new records are reported from the West Indian islands of St. John and Montserrat. Some of the populations may be accidental introductions through the movement of horticultural materials and more can be expected.