bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Bias-Correction Type and Conditional Training on Bayesian Model Averaging over the Northeast United States
Authors: Erickson Michael J. , Colle Brian A. , Charney Joseph J. 
Published: June 2012

Abstract
The performance of a multimodel ensemble over the northeast United States is evaluated before and after applying bias correction and Bayesian model averaging (BMA). The 13-member Stony Brook University (SBU) ensemble at 0000 UTC is combined with the 21-member National Centers for Environmental Prediction (NCEP) Short-Range Ensemble Forecast (SREF) system at 2100 UTC. The ensemble is verified using 2-m temperature and 10-m wind speed for the 2007–09 warm seasons, and for subsets of days with high ozone and high fire threat. The impacts of training period, bias-correction method, and BMA are explored for these potentially hazardous weather events using the most recent consecutive (sequential training) and most recent similar days (conditional training). BMA sensitivity to the selection of ensemble members is explored. A running mean difference between forecasts and observations using the last 14 days is better at removing temperature bias than is a cumulative distribution function (CDF) or linear regression approach. Wind speed bias is better removed by adjusting the modeled CDF to the observation. High fire threat and ozone days exhibit a larger cool bias and a greater negative wind speed bias than the warm-season average. Conditional bias correction is generally better at removing temperature and wind speed biases than sequential training. Greater probabilistic skill is found for temperature using both conditional bias correction and BMA compared to sequential bias correction with or without BMA. Conditional and sequential BMA results are similar for 10-m wind speed, although BMA typically improves probabilistic skill regardless of training.
Aggressiveness in different presentations of cluster headache: Results from a controlled multicentric study
Authors: Luerding Ralf , Henkel Karsten , Gaul Charly , Dresler Thomas , Lindwurm Andrea , Paelecke-Habermann Yvonne , Leinisch Elke , Jürgens Tim P 
Published: June 2012

Background: The hypothalamus has been discussed as a pivotal structure for both cluster headache (CH) and aggressiveness, but little is known about the extent of self-reported aggressiveness in patients with CH. Patients and methods: Twenty-six patients with chronic, 25 with active episodic and 22 with episodic CH outside the active period were examined interictally with a validated questionnaire quantifying factors of aggression and compared with 24 migraine patients and 31 headache-free volunteers. Results: The ANOVA was significant for the subscale ‘self-aggression/depression’ ( F4, 123 = 5.771, p < 0.001) with significant differences between chronic and episodic CH and healthy volunteers. No significant changes were found for other subscales and the sum scale ( F4, 123 < 1.421, p > 0.230). Especially in the clinically most affected group of patients (chronic CH and active episodic CH), high levels of “self-aggression/depression” correlate with higher prevalence of depressive symptoms and higher impairment measured on an emotional and functional level. Discussion: Self-aggressive and depressive cognitions with highest scores in chronic CH seem to be reactive as they correlate with depressive symptoms and impairment. They should be considered as an important therapeutic target since they impair the patient’s life significantly.
Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes
Authors: Randriamboavonjy Voahanginirina , Isaak Johann , Elgheznawy Amro , Pistrosch Frank , Frömel Timo , Yin Xiaoke , Badenhoop Klaus , Heide Heinrich , Mayr Manuel , Fleming Ingrid 
Published: June 2012

Abstract
Platelets from patients with diabetes are hyperreactive and demonstrate increased adhesiveness, aggregation, degranulation, and thrombus formation, processes that contribute to the accelerated development of vascular disease. Part of the problem seems to be dysregulated platelet Ca2+ signaling and the activation of calpains, which are Ca2+-activated proteases that result in the limited proteolysis of substrate proteins and subsequent alterations in signaling. In the present study, we report that the activation of μ- and m-calpain in patients with type 2 diabetes has profound effects on the platelet proteome and have identified septin-5 and the integrin-linked kinase (ILK) as novel calpain substrates. The calpain-dependent cleavage of septin-5 disturbed its association with syntaxin-4 and promoted the secretion of α-granule contents, including TGF-β and CCL5. Calpain was also released by platelets and cleaved CCL5 to generate a variant with enhanced activity. Calpain activation also disrupted the ILK-PINCH-Parvin complex and altered platelet adhesion and spreading. In diabetic mice, calpain inhibition reversed the effects of diabetes on platelet protein cleavage, decreased circulating CCL5 levels, reduced platelet-leukocyte aggregate formation, and improved platelet function. The results of the present study indicate that diabetes-induced platelet dysfunction is mediated largely by calpain activation and suggest that calpain inhibition may be an effective way of preserving platelet function and eventually decelerating atherothrombosis development.
MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors
Authors: Castanier Céline , Zemirli Naima , Portier Alain , Garcin Dominique , Bidère Nicolas , Vazquez Aimé , Arnoult Damien 
Published: June 2012

Abstract

Background
During a viral infection, the intracellular RIG-I-like receptors (RLRs) sense viral RNA and signal through the mitochondrial antiviral signaling adaptor MAVS (also known as IPS-1, Cardif and VISA) whose activation triggers a rapid production of type I interferons (IFN) and of pro-inflammatory cytokines through the transcription factors IRF3/IRF7 and NF-κB, respectively. While MAVS is essential for this signaling and known to operate through the scaffold protein NEMO and the protein kinase TBK1 that phosphorylates IRF3, its mechanism of action and regulation remain unclear.

Results
We report here that RLR activation triggers MAVS ubiquitination on lysine 7 and 10 by the E3 ubiquitin ligase TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling. Inhibition of this MAVS degradation with a proteasome inhibitor does not affect NF-κB signaling but it hampers IRF3 activation, and NEMO and TBK1, two essential mediators in type I IFN production, are retained at the mitochondria.

Conclusions
These results suggest that MAVS functions as a recruitment platform that assembles a signaling complex involving NEMO and TBK1, and that the proteasome-mediated MAVS degradation is required to release the signaling complex into the cytosol, allowing IRF3 phosphorylation by TBK1.
Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei
Authors: Freeman Kate , Brureau Anthony , Vadigepalli Rajanikanth , Staehle Mary M , Brureau Melanie M , Gonye Gregory E , Hoek Jan B , Hooper D Craig , Schwaber James S 
Published: June 2012

AbstractBackgroundChronic alcohol use changes the brain’s inflammatory state. However, there is little work examining the progression of the cytokine response during alcohol withdrawal, a period of profound autonomic and emotional upset. This study examines the inflammatory response in the central nucleus of the amygdala (CeA) and dorsal vagal complex (DVC), brain regions neuroanatomically associated with affective and cardiorespiratory regulation in anin vivorat model of withdrawal following a single chronic exposure.MethodsFor qRT-PCR studies, we measured the expression ofTNF-α,NOS-2,Ccl2 (MCP-1), MHC II invariant chainCD74, and the TNF receptorTnfrsf1ain CeA and DVC samples from adult male rats exposed to a liquid alcohol diet for thirty-five days and in similarly treated animals at four hours and forty-eight hours following alcohol withdrawal. ANOVA was used to identify statistically significant treatment effects. Immunohistochemistry (IHC) and confocal microscopy were performed in a second set of animals during chronic alcohol exposure and subsequent 48-hour withdrawal.ResultsFollowing a chronic alcohol exposure, withdrawal resulted in a statistically significant increase in the expression of mRNAs specific for innate immune markersCcl2,TNF-α,NOS-2,Tnfrsf1a, andCD74. This response was present in both the CeA and DVC and most prominent at 48 hours. Confocal IHC of samples taken 48 hours into withdrawal demonstrate the presence of TNF-α staining surrounding cells expressing the neural marker NeuN and endothelial cells colabeled with ICAM-1 (CD54) and RECA-1, markers associated with an inflammatory response. Again, findings were consistent in both brain regions.ConclusionsThis study demonstrates the rapid induction ofCcl2,TNF-α,NOS-2,Tnfrsf1aandCD74expression during alcohol withdrawal in both the CeA and DVC. IHC dual labeling showed an increase in TNF-α surrounding neurons and ICAM-1 on vascular endothelial cells 48 hours into withdrawal, confirming the inflammatory response at the protein level. These findings suggest that an abrupt cessation of alcohol intake leads to an acute central nervous system (CNS) inflammatory response in these regions that regulate autonomic and emotional state.
TBCRC 001: Randomized Phase II Study of Cetuximab in Combination With Carboplatin in Stage IV Triple-Negative Breast Cancer
Authors: Carey Lisa A. , Rugo Hope S. , Marcom P. Kelly , Mayer Erica L. , Esteva Francisco J. , Ma Cynthia X. , Liu Minetta C. , Storniolo Anna Maria , Rimawi Mothaffar F. , Forero-Torres Andres , Wolff Antonio C. , Hobday Timothy J. , Ivanova Anastasia , Chiu Wing-Keung , Ferraro Madlyn , Burrows Emily , Bernard Philip S. , Hoadley Katherine A. , Perou Charles M. , Winer Eric P. 
Published: June 2012

Purpose Epidermal growth factor receptor (EGFR) is a targetable receptor frequently overexpressed in basal-like breast cancer, which comprises most triple-negative breast cancers (TNBCs), the only subtype without established targeted therapy. Patients and Methods In this randomized phase II trial, patients with metastatic TNBC received anti-EGFR antibody cetuximab (400 mg/m2 load then 250 mg/m2 per week intravenously [IV]) alone, with carboplatin (area under the curve of 2, once per week IV) added after progression or as concomitant therapy from the beginning. Response rate (RR) was the primary end point; others included time to progression (TTP), overall survival (OS), and toxicity. Embedded correlative studies included molecular subtyping on archival tissue. Fresh tumor tissue before and after 7 to 14 days of therapy was used for microarray analyses exploring EGFR pathway activity and inhibition. Results In 102 patients with TNBC, RRs were 6% (two of 31) to cetuximab and 16% (four of 25) to cetuximab plus carboplatin after progression. RR to those treated from the beginning with cetuximab plus carboplatin was 17% (12 of 71); 31% of patients responded or had prolonged disease stabilization. The cetuximab plus carboplatin regimen was well tolerated, but both TTP and OS were short at 2.1 months (95% CI, 1.8 to 5.5 months) and 10.4 months (95% CI, 7.7 to 13.1 months), respectively. Of 73 patients with archival tissue for analysis, 74% had basal-like molecular subtype. Sixteen patients had tumor biopsies before and 1 week after therapy; genomic patterns of the EGFR pathway showed activation in 13 and inhibition by therapy in five. Conclusion Despite strong preclinical data, combination cetuximab plus carboplatin in metastatic TNBC produced responses in fewer than 20% of patients. EGFR pathway analysis showed that most TNBCs involved activation. However, cetuximab blocked expression of the EGFR pathway in only a minority, suggesting that most had alternate mechanisms for pathway activation.
Phase II Trial of Trastuzumab in Combination With Cytotoxic Chemotherapy for Treatment of Metastatic Osteosarcoma With Human Epidermal Growth Factor Receptor 2 Overexpression: A Report From the Children's Oncology Group
Authors: Ebb David , Meyers Paul , Grier Holcombe , Bernstein Mark , Gorlick Richard , Lipshultz Steven E. , Krailo Mark , Devidas Meenakshi , Barkauskas Donald A. , Siegal Gene P. , Ferguson William Shay , Letson George Douglas , Marcus Karen , Goorin Allen , Beardsley Peter , Marina Neyssa 
Published: June 2012

Purpose Despite efforts to intensify chemotherapy, survival for patients with metastatic osteosarcoma remains poor. Overexpression of human epidermal growth factor receptor 2 (HER2) in osteosarcoma has been shown to predict poor therapeutic response and decreased survival. This study tests the safety and feasibility of delivering biologically targeted therapy by combining trastuzumab with standard chemotherapy in patients with metastatic osteosarcoma and HER2 overexpression. Patients and Methods Among 96 evaluable patients with newly diagnosed metastatic osteosarcoma, 41 had tumors that were HER2-positive by immunohistochemistry. All patients received chemotherapy with cisplatin, doxorubicin, methotrexate, ifosfamide, and etoposide. Dexrazoxane was administered with doxorubicin to minimize the risk of cardiotoxicity from treatment with trastuzumab and anthracycline. Only patients with HER2 overexpression received concurrent therapy with trastuzumab given for 34 consecutive weeks. Results The 30-month event-free and overall survival rates for patients with HER2 overexpression treated with chemotherapy and trastuzumab were 32% and 59%, respectively. For patients without HER2 overexpression, treated with chemotherapy alone, the 30-month event-free and overall survival rates were 32% and 50%, respectively. There was no clinically significant short-term cardiotoxicity in patients treated with trastuzumab and doxorubicin. Conclusion Despite intensive chemotherapy plus trastuzumab for patients with HER2-positive disease, the outcome for all patients was poor, with no significant difference between the HER2-positive and HER2-negative groups. Although our findings suggest that trastuzumab can be safely delivered in combination with anthracycline-based chemotherapy and dexrazoxane, its therapeutic benefit remains uncertain. Definitive assessment of trastuzumab's potential role in treating osteosarcoma would require a randomized study of patients with HER2-positive disease.
Immunohistochemical Double-Hit Score Is a Strong Predictor of Outcome in Patients With Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone
Authors: Green Tina Marie , Young Ken H. , Visco Carlo , Xu-Monette Zijun Y. , Orazi Attilio , Go Ronald S. , Nielsen Ole , Gadeberg Ole V. , Mourits-Andersen Torben , Frederiksen Mikael , Pedersen Lars Møller , Møller Michael Boe 
Published: June 2012

Purpose Approximately 5% of diffuse large B-cell lymphomas (DLBCLs) are double-hit lymphomas (DHLs) with translocations of both MYC and BCL2. DHLs are characterized by poor outcome. We tested whether DLBCLs with high expression of MYC protein and BCL2 protein share the clinical features and poor prognosis of DHLs. Patients and Methods Paraffin-embedded lymphoma samples from 193 patients with de novo DLBCL who were uniformly treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) were studied using immunohistochemistry for MYC, BCL2, CD10, BCL6, and MUM1/interferon regulatory factor 4, and fluorescent in situ hybridization (FISH) for MYC and BCL2. Results FISH analysis identified DHL in 6% of patients, who showed the expected poor overall survival (OS; P = .002). On the basis of immunohistochemical MYC and BCL2 expression, a double-hit score (DHS) was assigned to all patients with DLBCL. The DHS-2 group, defined by high expression of both MYC and BCL2 protein, comprised 29% of the patients. DHS 2 was significantly associated with lower complete response rate (P = .004), shorter OS (P < .001), and shorter progression-free survival (PFS; P < .001). The highly significant correlation with OS and PFS was maintained in multivariate models that controlled for the International Prognostic Index and the cell-of-origin subtype (OS, P < .001; PFS, P < .001). DHS was validated in an independent cohort of 116 patients who were treated with R-CHOP. Conclusion The immunohistochemical DHS defined a large subset of DLBCLs with double-hit biology and was strongly associated with poor outcome in patients treated with R-CHOP.
Clostridium difficile–Associated Diarrhea at a Community Hospital: Ten-Year Analysis of Infection Rates and the Relationship with Proton Pump Inhibitor Use
Authors: Fashner Julia , Ribble Lisa , Garcia Marin 
Published: June 2012

Purpose To investigate the relationship between proton pump inhibitor (PPI) use and the incidence of Clostridium difficile–associated diarrhea (CDAD) at a community hospital. Methods The number of inpatient admissions, inpatient cases of CDAD, and PPI and antimicrobial doses were collected for each year from 2000 to 2009. Correlations between incidence of CDAD and doses of PPI and antimicrobials were calculated using Spearman's rank correlation coefficient analysis. Results The incidence of CDAD correlated with the number of doses of PPI per admission (ρ = 0.891, P < .001) and with the number of doses of antimicrobials per admission (ρ = 0.806, .005 > P > .001). The correlation of CDAD incidence with high-risk and low-risk antimicrobials was significant for both groups (ρ = 0.624, .05 > P > .025, and ρ = 0.881, P < .001, respectively). The correlation of oral and intravenous PPI dosing and CDAD incidence was significant for both (ρ=0.903, P < .001, and ρ=0.806, .005 > P > .001, respectively). Multiple regression analysis with both antimicrobials and PPIs as predictors of CDAD was statistically significant ( R2 = 0.75, P = .0082). Conclusion The incidence of CDAD is correlated with PPI use. Antimicrobials are a well-established risk factor for CDAD, and our study reinforces this. Prescribers should consider limiting risk of CDAD by the judicious use of PPIs.
REVIEWS
Authors: Buckley Brad , Flood Adele , Tan Su-Lynn 
Published: June 2012

THE PLEASURE OF RESEARCH, HENK SLAGER (2012) Helsinki: Finnish Academy of Fine Arts, Helsinki, 88 pp., ISBN: 978-951-53-3397-1, p/bk
THINK INSIDE THE SKETCH BOOK, GILLIAN ROBINSON, DAVID HULSTON AND ALISON MOUNTAIN (2011) London: Harper Collins Publishers Limited, 93 pp., ISBN: 978-0-00-743479-4,
p/bk, £25.00
EXTRAORDINARY SKETCHBOOKS, JANE STOBART (2011) London: A & C Black, Bloomsbury Publishing PLC, 144 pp., ISBN: 978-1-4081-3442-9, p/bk, £16.99
BOOK REVIEWS
Authors: Larson Jared D. , García-Guirao Pedro 
Published: June 2012

Spain Transformed: The Late Franco Dictatorship, 1959–75,Nigel Townson(ed.) (2010) Basingstoke: Palgrave Macmillan, v–xi, 1–265 pp., ISBN 978-0-230-00455-9 (hbk), 978-0-230-24888-5 (pbk), 55.00/18.99
We, the Anarchists! A Study of Iberian Anarchist Federation (FAI)
1927–1937, StuartChristie (2008) Edinburgh and Oakland, CA: AK Press, viii + 235 pp., ISBN 978-1-90485-975-8 (pbk), 9.95
REVIEWS
Authors: Collier David , Honing Henkjan , Oliver Rowan 
Published: June 2012

AN INTRODUCTION TO MUSIC TECHNOLOGY, DAN HOSKEN (2010) New York: Routledge, 400 pp., ISBN: 978-0-415-99729-4, p/bk, £25.99
THE MUSIC INSTINCT: HOW MUSIC WORKS AND WHY WE CAN'T DO WITHOUT IT, PHILIPBALL (2011) London: Vintage, 452 pp., ISBN: 978-0-099-53544-7, p/bk, £9.99
IF
MUSIC ISNT A LUXURY, WHAT IS IT?
SONIC BODIES: REGGAE SOUND SYSTEMS, PERFORMANCE TECHNIQUES AND WAYS OF KNOWING, JULIAN HENRIQUES (2011) New York: Continuum International, 352 pp., ISBN: 978-1-4411-4429-4, p/bk, £17.99
Influence of the viscosity of UF resins on the radial and tangential penetration into poplar wood and on the shear strength of adhesive joints
Authors: Gavrilovic-Grmusa Ivana , Dunky Manfred , Miljkovic Jovan , Djiporovic-Momcilovic Milanka 
Published: June 2012

Abstract
This paper is the final part of a series reporting on the penetration (P) and bonding behaviour of urea-formaldehyde (UF) resins of different viscosities based on different degrees of condensation (DCs). The various resins were applied onto radial and tangential wood surfaces, and solid wood assemblies were prepared by hot pressing. Pt and Pr were observed by evaluation of photomicrographs of the bond lines. The mean and maximum depth of penetration was inversely proportional to the DC. The average depth of Pt was found to be slightly higher than Pr because of the abundance of pits on the radial walls. However, the maximum P was higher in radial direction, due to the elliptic shape of vessels in poplar as well as due to rays improving the resin flow. The lap shear strength (σm) of the same bonded assemblies was determined. Despite the fact that the wood failure always was very high, the σm increased with the better penetration of the resins with low viscosity. The higher strength values measured has been interpreted as a fortification effect of the interphase by bulk resin penetration, as cell wall penetration cannot be expected due to the large size of such resin molecules.
Nanostructure designs for effective solar-to-hydrogen conversion
Authors: Shen Shaohua , Mao Samuel S. 
Published: June 2012

Abstract
Conversion of energy from photons in sunlight to hydrogen through solar splitting of water is an important technology. The rising significance of producing hydrogen from solar light via water splitting has motivated a surge of developing semiconductor solar-active nanostructures as photocatalysts and photoelectrodes. Traditional strategies have been developed to enhance solar light absorption (e.g., ion doping, solid solution, narrow-band-gap semiconductor or dye sensitization) and improve charge separation/transport to prompt surface reaction kinetics (e.g., semiconductor combination, co-catalyst loading, nanostructure design) for better utilizing solar energy. However, the solar-to-hydrogen efficiency is still limited. This article provides an overview of recently demonstrated novel concepts of nanostructure designs for efficient solar hydrogen conversion, which include surface engineering, novel nanostructured heterojunctions, and photonic crystals. Those first results outlined in the main text encouragingly point out the prominence and promise of these new concepts principled for designing high-efficiency electronic and photonic nanostructures that could serve for sustainable solar hydrogen production.
Optische Geschwindigkeitsmessungen an Luft-haltenden Deckflügeln des Notonecta glauca
Authors: Melskotte Jan-Erik , Brede Martin , Leder Alfred , Mayser Matthias , Barthlott Wilhelm 
Published: June 2012

Zusammenfassung
Mit den superhydrophoben, Luft haltenden Deckflügeln des Rückenschwimmers Notonecta glaucazeigt die Natur, wie die Benetzung einer Oberfläche beim Untertauchen in Wasser erfolgreich verhindert werden kann. Die Auswirkung dieser Eigenschaft auf das strömungsmechanische Verhalten werden mittels μ-Particle-Image-Velocimetry Messtechnik untersucht. Durch das Gleiten des Wassers an der Luft-Wasser-Grenzfläche wird in diesen Oberflächen ein Beispiel zur Reibungsreduktion gesehen, das einen Ansatz für den Aufbau technischer Oberflächen darstellt. Zudem zeigt die Struktur des Notonecta glauca-Deckflügels eine beachtliche Lufthaltefähigkeit bei Strömungsgeschwindigkeiten bis 5 m/s.
Erweiterung der Zeitverschiebungstechnik auf Blasenmessungen an Kavitationskanälen
Authors: Höhne Stephan , Kretschmer Arno , Kröger Willfried , Borchert Stefan , Damaschke Nils 
Published: June 2012

Zusammenfassung
Der Beitrag behandelt die Adaption des Zeitverschiebungsverfahrens (ZVV) zur Charakterisierung von Blasen. In bisherigen Experimenten wurde das ZVV an Wassertropfen im Vergleich zur Phasen-Doppler-Technik validiert. Vorgestellt wird die Generierung des Zeitverschiebungssignals für Blasen anhand von Simulationen, bei der Größenbestimmung von Einzelblasen in einer Laborblasensäule sowie erste Messungen von Blasen in einem Kavitationskanal.