bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epoetin Theta in Anaemic Cancer Patients Receiving Platinum‐Based Chemotherapy: A Randomised Controlled Trial
Authors: Tjulandin Sergei A. , Bias Peter , Elsässer Reiner , Gertz Beate , Kohler Erich , Buchner Anton 
Published: November 2010

ABSTRACTIntroduction.  Recombinant human erythropoietin (r‐HuEPO) is used to treat symptomatic anaemia due to chemotherapy. A new r‐HuEPO, Epoetin theta (Eporatio®), was investigated and compared to placebo and Epoetin beta in a randomised, double‐blind clinical trial in adult cancer patients receiving platinum‐based chemotherapy, using a fixed weekly starting dose of 20,000 IU Epoetin theta. The primary efficacy endpoint was the responder rate (complete Hb response, Hb increase ≥ 2 g/dL).Research Design and Methods.  223 patients were randomised to s.c. treatment for 12 weeks with either Epoetin theta (n = 76) once per week, Epoetin beta (n = 73) three times per week or placebo (n = 74). The starting dose was 20,000 IU once weekly Epoetin theta or 450 IU/kgBW per week Epoetin beta administered in 3 equal weekly doses.Results.  In the Epoetin theta group were significantly more responders than in the placebo group (65.8 vs. 20.3%, P < 0.0001). Epoetin beta was also more effective than placebo (71.2 vs. 20.3%, P < 0.0001). The mean weekly dose at the time of complete Hb response was lower in the Epoetin theta group (30,000 IU) than in the Epoetin beta group (42,230 IU). Epoetin theta was clearly more effective than placebo.Conclusion.  This small study showed, that Epoetin theta is a safe and effective treatment of symptomatic anaemia due to platinum‐based chemotherapy in cancer patients.
Deformation Characteristics and Time-Dependent Notch Sensitivity of
Udimet 700 at Intermediate Temperatures
Authors: Wilson D. J. 
Published: November 2010

Abstract
Time-dependent notch sensitivity of Udimet 700 sheet, bar, and investment castings was observed between 1000 deg and 1400 deg F (538–760 deg C) but not at 1600 deg F (871 deg C). As was the case for Modified Waspaloy, Waspaloy, Rene´ 41, INCONEL 718 and TD-NiCr, it occurred when notched specimens were loaded below the yield strength and when creep deformation was localized. For each γ′ strengthened alloy and notched specimen geometry, a stress-average particle size zone can be defined to characterize the notch sensitive behavior.
Modeling cadmium uptake from water and food by the freshwater bivalve Pyganodon grandis
Authors: Cooper Sophie , Hare Landis , Campbell Peter G.C. 
Published: November 2010

For this study, the unionid bivalve Pyganodon grandis was either exposed to dissolved cadmium (Cd) or fed Cd-contaminated algae ( Pseudokirchneriella subcapitata ) during short-term laboratory experiments. Cadmium accumulated largely in the digestive gland after a dietary exposure, or in the gills after an aqueous exposure; in these latter experiments, Cd accumulation from the dissolved phase increased as bivalve filtration rates increased. The results of these uptake experiments were used to parameterize a biodynamic model, which was then used to estimate the relative importance of water and food as sources of Cd for this bivalve, and to predict steady state Cd concentrations in the gills and digestive gland of native bivalves. In comparisons between the simulations and data obtained from earlier field studies on P. grandis, the model adequately predicted Cd concentrations in P. grandis gills, except in Ca-rich lakes, whereas it tended to overestimate Cd concentrations in the digestive gland. The field simulations indicate that water is the main source of Cd for both the gills (relative importance water:food::99:1) and the digestive gland (water:food::80:20). These results will facilitate the interpretation of spatial and temporal variations in Cd concentrations in free-living P. grandis, which is a promising metal biomonitor.
A mixed reality approach for interactively blending dynamic models with corresponding physical phenomena
Authors: Quarles John , Fishwick Paul , Lampotang Samsun , Fischler Ira , Lok Benjamin 
Published: November 2010

The design, visualization, manipulation, and implementation of models for computer simulation are key parts of the discipline. Models are constructed as a means to understand physical phenomena as state changes occur over time. One issue that arises is the need to correlate models and their components with the phenomena being modeled. For example, a part of an automotive engine needs to be placed into cognitive context with the diagrammatic icon that represents that part's function. A typical solution to this problem is to display a dynamic model of the engine in one window and the engine's CAD model in another. Users are expected to, on their own, mentally blend the dynamic model and the physical phenomenon into the same context. However, this contextualization is not trivial in many applications.
Our approach expands upon this form of user interaction by specifying two ways in which dynamic models and the corresponding physical phenomena may be viewed, and experimented with, within the same human interaction space. We present a methodology and implementation of contextualization for diagram-based dynamic models using an anesthesia machine, and then follow up with a human study of its effects on spatial cognition.
Host status of some selected Brazilian upland rice cultivars to Meloidogyne incognita race 4 and Rotylenchulus reniformis
Authors: Filho Jerônimo V. de Araújo , Machado Andressa C.Z. , Ferraz Luiz C.C.B. 
Published: November 2010

Abstract
Nowadays, rice is among the most preferred crops for rotation with soybean
and cotton in the large producing areas of Central Brazil. Nevertheless, the
host status of the Brazilian upland rice cultivars for Meloidogyne incognita
race 4 and Rotylenchulus reniformis has not been investigated and remains
unknown. This study dealt with the assessment of the host response of some
selected Brazilian upland rice cultivars to these nematodes under glasshouse
conditions. The host status for each tested interaction was based on the
nematode reproduction factor (RF) and number of nematodes (g root)–1. Two
experiments with M. incognita race 4, referred to as trial 1 (initial
population (IP) = 4000) and trial 2 (IP = 800), included, respectively, 14
cultivars (cvs AN Cirad 141, BRS Monarca, BRS Primavera, AN Cambará, BRS
Pepita, BRS Curinga, BRS Sertaneja, IAPAR 9, IAPAR 62, IAPAR 63, IAPAR 64,
IAPAR 117, IAC 201, IAC 202) and 19 cultivars (the same ones in Experiment 1
plus cvs BRS Maravilha, BRS Talento, BRS Bonança, Ricetec Ecco, BRS
Soberana). Except for cv. BRS Pepita, rated as resistant, the cultivars were
rated as susceptible or moderately susceptible (RF means ranged from 1.09 to
12.56). In a third experiment with R. reniformis (IP = 1800) that included
the same cultivars as in Experiment 1, all cultivars were rated as resistant
(RF means ranged from 0.01 to 0.29).
Impediments to the Expulsion of Non-Nationals: Substance and Coherence in Procedural Protection under the European Convention on Human Rights
Authors: Bryan Ian , Langford Peter 
Published: November 2010

AbstractThis article offers a critical assessment of the interpretative positions adopted by the European Court of Human Rights as to the applicability of Convention rights and freedoms to the deportation of “aliens” resident in the territory of a Contracting State. The article considers inconsistencies in the Court's jurisprudence and argues that these inconsistencies are a result of the characterisation of deportation proceedings as administrative events. The authors also explore the nature of Contracting States' deportation procedures and examine key features of the procedural guarantees afforded to non-nationals under the Convention and its Protocols. In addition, the authors consider the extent to which Convention notions of due process and natural justice are deemed germane to deportation proceedings. The article contends that disparities in the procedural protections accorded to nationals when compared with resident non-nationals conflict with the purpose of the European Convention on Human Rights are an avertable consequence of the primacy of State sovereignty.
Saccharomyces cerevisiae glycerol/H+ symporter Stl1p is essential for cold/near-freeze and freeze stress adaptation. A simple recipe with high biotechnological potential is given
Authors: Tulha Joana , Lima Ana , Lucas Cândida , Ferreira Célia 
Published: November 2010

Abstract

Background
Freezing is an increasingly important means of preservation and storage of microbial strains used for many types of industrial applications including food processing. However, the yeast mechanisms of tolerance and sensitivity to freeze or near-freeze stress are still poorly understood. More knowledge on this regard would improve their biotechnological potential. Glycerol, in particular intracellular glycerol, has been assigned as a cryoprotectant, also important for cold/near-freeze stress adaptation. The S. cerevisiae glycerol active transporter Stl1p plays an important role on the fast accumulation of glycerol. This gene is expressed under gluconeogenic conditions, under osmotic shock and stress, as well as under high temperatures.

Results
We found that cells grown on STL1 induction medium (YPGE) and subjected to cold/near-freeze stress, displayed an extremely high expression of this gene, also visible at glycerol/H+ symporter activity level. Under the same conditions, the strains harbouring this transporter accumulated more than 400 mM glycerol, whereas the glycerol/H+ symporter mutant presented less than 1 mM. Consistently, the strains able to accumulate glycerol survive 25-50% more than the stl1Δ mutant.

Conclusions
In this work, we report the contribution of the glycerol/H+ symporter Stl1p for the accumulation and maintenance of glycerol intracellular levels, and consequently cell survival at cold/near-freeze and freeze temperatures. These findings have a high biotechnological impact, as they show that any S. cerevisiae strain already in use can become more resistant to cold/freeze-thaw stress just by simply adding glycerol to the broth. The combination of low temperatures with extracellular glycerol will induce the transporter Stl1p. This solution avoids the use of transgenic strains, in particular in food industry.
Sp1 acetylation is associated with loss of DNA binding at promoters associated with cell cycle arrest and cell death in a colon cell line
Authors: Waby Jennifer S , Chirakkal Haridasan , Yu ChenWei , Griffiths Gareth J , Benson Roderick SP , Bingle Colin D , Corfe Bernard M 
Published: November 2010

Abstract
Butyrate, a known histone deacetylase inhibitor (HDACi) and product of fibre fermentation, is postulated to mediate the protective effect of dietary fibre against colon cancer. The transcription factor Sp1 is a target of acetylation and is known to be associated with class I HDACs, including HDAC1. Sp1 is a ubiquitous transcription factor and Sp1-regulated genes include those involved in cell cycle regulation, apoptosis and lipogenesis: all major pathways in cancer development. The only known acetylated residue of Sp1 is lysine703 which resides in the DNA binding domain. Here we show that acetylated Sp1 loses p21- and bak-promoter -binding function in vitro. Furthermore treatment with a panel of HDAC inhibitors showed clustering of activities for a subset of inhibitors, causing G2 cell cycle arrest, Sp1 acetylation, p21 and Bak over-expression, all with very similar EC50 concentrations. These HDACi activities were not distributed according to the molecular class of compound. In order to mimic loss of binding, an siRNA strategy was used to reduce Sp1 expression. This resulted in altered expression of multiple elements of the p53/p21 pathway. Taken together our data suggest a mechanistic model for the chemopreventive actions of butyrate in colon epithelial cells, and provide new insight into the differential activities some classes of HDAC inhibitors.
Les romanciers québécois et la « définition idéale » du roman autour de 1960. Le cas de Robert Charbonneau
Authors: Bélisle Mathieu 
Published: November 2010

RÉSUMÉ Au début des années 1960, des professeurs de l'Université d'Ottawa lancent un vaste chantier visant à dresser un état des lieux de la littérature canadienne-française. Pour le tome des Archives des Lettres canadiennes consacré à la situation du roman et à son « évolution » (1964), Paul Wyczynski et son équipe de rédaction sollicitent l'avis de plusieurs romanciers en vue, de Félix-Antoine Savard à Jacques Godbout, en passant par Gabrielle Roy et Gérard Bessette. Parmi les questions soumises aux répondants, questions qui traitent aussi bien des filiations, des enjeux institutionnels que de la pratique de l'écriture, nous nous intéressons ici à la plus hypothétique de toutes : « Quelle serait d'après vous la définition idéale du roman? » Cet article se propose d'étudier la réponse de Robert Charbonneau, dont l'intérêt tient au fait qu'elle réalise à la fois la synthèse et le bilan d'une pensée riche, affirmée et ambitieuse. À la différence des autres répondants, Charbonneau, l'un des rares — sinon le seul — romanciers québécois d'avant 1960 à avoir consacré à l'art du roman des essais et des études, n'insiste pas sur l'indéfinition native du genre ou sur son caractère protéiforme. Et s'il paraît éluder la question de sa définition idéale, ce n'est que pour imposer avec plus de vigueur et de conviction ce qu'il considère comme son objet fondamental : le personnage.
Sur un rêve d'André Gide
Authors: Pradeau Christophe 
Published: November 2010

RÉSUMÉ Dans le Journal des Faux-monnayeurs, à côté des réflexions théoriques suscitées par le chantier romanesque, sont insérés des textes narratifs dépourvus de caractère réflexif — anecdotes, choses vues, faits divers… — dont le statut est celui de documents génétiques : « sources », pistes abandonnées… Un seul texte échappe à ce dispositif, l'entrée du 5 mars 1923, consacrée pour l'essentiel à un récit de rêve mettant en scène Gide en visite chez Proust. Le contexte de publication invite à le lire comme une façon indirecte de se situer vis-à-vis du romancier récemment disparu. Dans quelle mesure est-on autorisé à interpréter ce récit comme un dispositif allégorique où se dirait obliquement la conception gidienne du roman? Quels sont les enjeux d'un tel recours à l'allégorie? Qu'est-il susceptible de nous apprendre sur les spécificités d'une poétique des praticiens? La poétique gidienne du roman est sans doute moins à chercher dans les aphorismes du Journal des Faux-monnayeurs que dans une certaine façon de se dégager des influences, dans la souplesse avec laquelle Gide circule d'une « source » à l'autre, veillant à ce que le lecteur ne s'arrête à aucune, constituant ainsi en poétique la mobilité d'un mode de vie.
Association of RANBP1 haplotype with smooth pursuit eye movement abnormality
Authors: Cheong Hyun Sub , Park Byung Lae , Kim Eun Mi , Park Chul Soo , Sohn Jin‐Wook , Kim Bong‐Jo , Kim Jae Won , Kim Ki‐Hoon , Shin Tae‐Min , Choi Ihn‐Geun , Han Sang‐Woo , Hwang Jaeuk , Koh InSong , Shin Hyoung Doo , Woo Sung‐Il 
Published: November 2010

AbstractSchizophrenia is a multifactorial disorder and smooth pursuit eye movement (SPEM) disturbance is proposed as one of the most consistent neurophysiological endophenotype in schizophrenia. The aim of this study was to examine the genetic association of RANBP1 polymorphisms with the risk of schizophrenia and with the risk of SPEM abnormality in schizophrenia patients in a Korean population. Two SNPs of RANBP1 were genotyped by TaqMan assay. Their genetic effect of single/haplotype polymorphisms on the risk of schizophrenia and SPEM abnormality from 354 patients and 396 controls were performed using χ2 and multiple regression analyses. Although no RANBP1 polymorphisms were associated with the risk of schizophrenia, a common haplotype, RANBP1‐ht2 (rs2238798G–rs175162T), showed significant association with the risk of SPEM abnormality among schizophrenia patients after multiple correction (Pcorr = 0.002–0.0003). The results of present study provide the evidence that RANBP1 on 22q11.21 locus might be causally related to the SPEM abnormality rather than the development of schizophrenia. © 2010 Wiley‐Liss, Inc.
Gross anatomy and arterial vascularization of the tympanic cavity and osseous labyrinth in mid‐gestational bovine fetuses
Authors: Erdogan Serkan , Kilinc Mehmet 
Published: November 2010

AbstractThis study aims to determine morphological features of certain aural formations, varietal characteristics, and arterial supply in fetal development period in cattle. For this purpose, ears of 10 bovine fetuses in mid‐gestation were evaluated. Organ morphology and vascularization in prenatal life were investigated by using corrosion cast technique. It was observed that some aspects of osseous formation and vascular organization in middle and inner ears were not developed completely in the first half of gestation; in addition, cochlea did not its snail‐like structure yet, lateral semicircular canal was rather low compared to others and auditory ossicles did not take its final shape. The feeding blood vessels of inner ear were found to demonstrate three different distribution patterns, whereas feeding pattern in middle ear was very similar in many specimens. The presence of stapedial artery was also identified. Differences and similarities with other some species were assessed in terms of both general morphological structure and vascular organization. From this regard, it is thought that this study will constitute a comparative model for both humans and other species and provide morphological contributions since there is not sufficient literature on species‐specific ear morphology in the field of veterinary anatomy in contrast to the abundance of studies on humans. Anat Rec, 2010. © 2010 Wiley‐Liss, Inc.
Improved performance of UV‐LED by p‐AlGaN with graded composition
Authors: Yan Jianchang , Wang Junxi , Cong Peipei , Sun Lili , Liu Naixin , Liu Zhe , Zhao Chao , Li Jinmin 
Published: November 2010

AbstractAlGaN‐based ultraviolet light emitting diodes (UV‐LEDs) on AlN/sapphire template were grown by metal organic chemical vapour deposition. The AlN template was characterized by atomic force microscopy and high resolution X‐ray diffraction. Atomic force microscopy image shows that the AlN surface is very flat, while high resolution X‐ray diffraction results prove the good crystalline quality of the AlN template. A novel structure UV‐LED which has several p‐AlGaN layers with graded composition is compared with a common structure UV‐LED which has a single p‐Al0.5Ga0.5N layer. The forward bias voltage at 20 mA driving current for the novel structure UV‐LED is nearly 3 V higher than that of the common structure UV‐LED, however, the electroluminescence intensity of the former is over two times higher than that of the latter. The total quantum efficiency of the novel structure UV‐LED is more than 50% higher than that of the common structure UV‐LED. The improvement is considered to be the result of better holes injection efficiency in the novel structure UV‐LED. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Scientific literacy, pleasure and aesthetics: the collaborative virtual worlds that Galileo could not foresee
Authors: Bortoletto Daiana R. , de Oliveira-Abans Mariângela , Júnior Propércio G. Guida , de Fernandes Iranderly F. , Santos Rafael 
Published: November 2010

AbstractWe present the various activities and infrastructure dedicated to educational scientific and technological outreach of the MCT/Laboratório Nacional de Astrofísica, Brazil and how useful they are in diminishing the scientific illiteracy of the layman, the young, the senior citizens and the handicapped. We also explore the future endeavors and commitments that scientists and educators are to face in order to bring enlightenment.
Study of mutual occultation phenomena of the Galilean satellites at radio wavelengths
Authors: Pluchino S. , Salerno E. , Pupillo G. , Schillirò F. , Kraus A. , Mack K.-H. 
Published: November 2010

AbstractWe present preliminary results for our study of mutual phenomena of the Galilean satellites performed at radio wavelengths with the Medicina and Noto antennas of the Istituto di Radioastronomia - INAF, and with the Effelsberg 100-m radio telescope of the Max-Planck-Institute for Radioastronomy, Bonn. Measurements of the radio flux density variation during the mutual occultations of Io by Europa and Ganymede were carried out during the PHEMU09 campaign at 22 GHz and 43 GHz. Flux density variations observed at radio wavelengths are consistent with the typical optical patterns measured when partial occultations occur.
Differential Testing and the Evaluation of Thermal Activation
Parameters
Authors: Wagner J. G. 
Published: November 2010

Abstract
Thermally activated mechanisms of dislocation motion and interaction account for the dependence of stress on strain, temperature, and time during plastic deformation. Much of the recent activity in identifying particular mechanisms has involved the use of differential type thermomechanical tests. Due to certain basic and recurrent oversights in applying thermal activation theory to such test data, the results are oftentimes misleading. These limitations are identified and explored. Minimum requirements for an accurate characterization of strain history effects are established. A limited amount of self-contained isothermal data, for aluminum and lead, have been obtained in the intermediate strain-rate range which critically test the hypotheses. The present results indicate that the results reported by others may be in substantial error. Much of the discussion presented also applies, in its most basic form, to the evaluation of constitutive models which are not microstructurally based.
Effect of Wind-Tunnel Walls on the Flow Past Circular Cylinders and
Cooling Tower Models
Authors: Farell César , Carrasquel Saul , Güven Oktay , Patel V. C. 
Published: November 2010

Abstract
The effect of wind tunnel walls on the mean pressure distributions on rough-walled circular cylinders and on cooling tower models fitted with longitudinal ribs is studied experimentally in the range of Reynolds-number independence. For circular cylinders the results are compared with analytical corrections based on formulae of Allen and Vincenti, and of Maskell, which are found to be generally applicable in this Reynolds number range. For cooling towers, a correction procedure is proposed using the base pressure coefficient, Cpb, and the dimensionless pressure rise to separation, Cpb–Cpm, where Cpm is the minimum value of the pressure coefficient. The base pressure coefficient Cpb for cooling towers is (in the Reynolds-number-independent range) a function of the boundary geometry: model shape, tunnel type (open or closed jet) and blockage, and is independent of surface roughness. The difference Cpb–Cpm, on the other hand, is mainly a function of surface roughness for both cylinders and cooling towers and is very little, if at all, affected by tunnel blockage for blockages less than, say, 15 percent.
A Preliminary Study of Flow and Acoustic Phenomena in Tube
Banks
Authors: Fitzpatrick J. A. , Donaldson I. S. 
Published: November 2010

Abstract
Experiments have been performed in a low turbulence wind tunnel to investigate the effect of tube pitch to diameter ratios, depth of bank, and Reynolds number on the parameters associated with resonant acoustic vibration in in-line tube banks. Results indicate that the depth of a bank is a significant factor in acoustic response characteristics and both the vortex shedding hypothesis and the turbulent buffeting hypothesis are shown to be inadequate for certain configurations. A combination of both hypotheses together with energy levels in the turbulence spectrum is suggested, although no definitive proof is offered.