bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual problems in women during the first postpartum year and related conditions
Authors: Acele Elif Özge , Karaçam Zekiye 
Published: October 2011

Aim.  The aim of this study was to evaluate the sexual problems in women during the first postpartum year and related conditions.Background.  In the postpartum period, women encounter numerous physical, psychological and sociocultural factors. These factors negatively affect both the sexual function and the quality of life of woman.Design.  A descriptive survey.Methods.  In this study, 230 women were included. The study was conducted between September 2007 and December 2008 in Izmir, Turkey. A questionnaire form developed by authors, the Arizona Sexual Experience Scale‐female version and the Beck depression inventory were applied for participants.Results.  The women began to have sexual intercourse within 7·06 weeks after delivery. Of the women, 58·3% reported that they had dyspareunia in the postpartum period. According to Arizona Sexual Experience Scale, the total score was ≥11 in 91·3% of women and they had sexual problems in the first postpartum year. The results of the multivariate analysis revealed that the increase in age, the presence of sexual problems during pregnancy and the increase in time after delivery significantly increased the possibility of postpartum sexual problems.Conclusion.  This study revealed that the majority of the women had postpartum sexual problems and the possibility of postpartum sexual problems increased with the increase in age, the presence of sexual problems during pregnancy and the increase in time after delivery.Relevance to clinical practice.  Healthcare professionals should evaluate women in terms of their sexual functions during both pregnancy and postpartum period. Health education, counselling, referral services for early diagnosis and treatment might contribute to the protection and improvement of the sexual health of women during the postpartum period.
Enhancing e‐learning quality through the application of the AKUE procedure model
Authors: Bremer C. 
Published: October 2011

AbstractThe paper describes the procedure model AKUE, which aims at the improvement and assurance of quality and cost efficiency in the context of the introduction of e‐learning and the development of digital learning material. AKUE divides the whole planning and implementation process into four different phases: analysis, conception, implementation, and evaluation. AKUE analyses at which level of the organization or curriculum decisions have to be made. Accordingly, it differentiates various types of projects for which different planning methods and quality criteria are applied. For each step, specific worksheets and procedures are applied in order to support planning and decision making. Through the definition of outcomes and feedback loops at each step, quality standards and cost efficiency can be achieved.
Higher education scholars' participation and practices on Twitter
Authors: Veletsianos G. 
Published: October 2011

AbstractScholars participate in online social networks for professional purposes. In such networks, learning takes the form of participation and identity formation through engagement in and contribution to networked practices. While current literature describes the possible benefits of online participation, empirical research on scholars' use of online social networks in the educational technology literature is negligible. The purpose of this paper is to understand scholars' naturalistic practices in social networks in general, and on Twitter in particular. Tweets from 45 scholars were analysed qualitatively to arrive at dominant themes describing online social network practice. Findings indicate that scholars participating on Twitter (1) shared information, resources, and media relating to their professional practice; (2) shared information about their classroom and their students; (3) requested assistance from and offered suggestions to others; (4) engaged in social commentary; (5) engaged in digital identity and impression management; (6) sought to network and make connections with others; and (7) highlighted their participation in online networks other than Twitter. These findings assist the field in understanding the emerging practice of scholarly participation in online networks.
The importance of lipid solubility and receptor selectivity of β‐adrenoceptor blocking drugs for the occurrence of symptoms and side‐effects in out‐patients
Authors: THEODORSEN L. , BRORS O. 
Published: October 2011

Abstract Theodorsen L, Brørs O (Department of Pharmacotherapeutics. University of Oslo, Oslo, Norway). The importance of lipid solubility and receptor selectivity of β‐adrenoceptor blocking drugs for the occurrence of symptoms and side‐effects in out‐patients.Short‐term studies indicate that the side‐effects of adrenergic β‐receptor blockade may be influenced by lipid solubility and receptor selectivity of the blockers. The aim of the present study was to investigate the extent to which lipid solubility and receptor selectivity are related to the occurrence of symptoms during ordinary β‐blocker treatment in out‐patients. Two hundred and five patients (mean age 60 years) on β‐blockade were interviewed about their symptoms. Eighty‐five per cent of the patients had been on β‐blocker treatment for more than 1 year. The blockers most commonly used were atenolol (51.0%). timolol (20.0%). propranolol (18.5%) and metoprolol (7.8%). β‐Blocker treatment was associated with a significantly increased frequency of central nervous system and peripheral symptoms. The increase in central nervous system symptoms was significantly smaller in those on β‐blockers with low rather than with intermediate (P = 0.015) or high lipid solubility (P = 0.007). The increase in peripheral symptoms was not significantly different with β1‐selective and non‐selective blockers. The results indicate that the liability of β‐blockers to cause side‐effects on the central nervous system is determined partly by their lipid solubility, and that receptor selectivity has only a small impact on their tendency to cause peripheral side‐effects.
Cod liver oil does not reduce ventricular extrasystoles after myocardial infarction
Authors: HARDARSON T. , KRISTINSSON Å. , SKÚLADÓTTIR G. , ÁSVALDSDÓTTIR H. , SNORRASON S. P. 
Published: October 2011

Abstract Hardarson T. Kristinsson Å, Skúladóttir G. Åsvaldsdóttir H. Snorrason SP (Department of Medicine, National University Hospital, Landspitalinn. and the Science Institute of University of Iceland. Reykjavik, Iceland). Cod liver oil does not reduce ventricular extrasystoles after myocardial infarction.Previous work has shown that in experimental animal models a lower incidence of arrhythmias and sudden death was observed if the animals were fed cod liver oil or fish oil. After a 48‐h control period starting, on average, 8 days after the onset of symptoms, 18 men who were recovering from acute myocardial infarction were given 20 ml d−1 cod liver oil for 6 weeks, either immediately after the control period, weeks 0–6 (n = 10). or during weeks 6–12 (n = 8). Forty‐eight‐hour Holter monitoring was carried out before cod liver oil administration and at the end of weeks 6 and 12. The eicosapentaenoic acid content of plasma phospholipids was increased by 230% during cod liver oil administration. However, no signficant change was observed in the 24‐h prevalence of ventricular extrasystoles or other arrhythmias during the study period. The mean In number of ventricular extrasystoles was 2.95 ± 0.51 (± SEM) during cod liver oil ingestion and 2.63 ± 0.30 when not taking cod liver oil.
Simultaneous neuroinfection with cytomegalovirus and herpes simplex virus in an immunocompetent adult
Authors: LARSEN J. K. , MELGAARD B. 
Published: October 2011

AbstractLarsen JK, Melgaard B (Department of Neurology, Centralsygehuset, Slagelse, Denmark). Simultaneous neuroinfection with cytomegalovirus and herpes simplex virus in an immunocompetent adult.An immunocompetent adult developed Guillain‐Barré Syndrome and encephalitis simultaneously. Serological and cerebrospinal fluid analyses provided evidence of both cytomegalovirus and herpes simplex virus infections. The patient recovered with only moderate sequelae following acyclovir treatment.
Protein C in renal allotransplantation during the perioperative period
Authors: SØRENSEN P. J. , NIELSEN A. H. , KNUDSEN F. , SCHMITZ O. , DYERBERG J. 
Published: October 2011

Abstract Sørensen PJ. Nielsen AH. Knudsen F. Schmitz O. Dyerberg J (Department of Nephrology. and Department of Clinical Chemistry. Aalborg Hospital. Aalborg. and Department of Nephrology. University Hospital of Århus. Århus. Denmark). Protein C in renal allotransplantation during the perioperative period.Protein C activity, both coagulant and amidolytic, as well as antigen level were studied during the perioperative period in 40 renal transplants recipients and 21 healthy controls. At transplantations the protein C coagulant activity was significantly lower in the patients than in the normal controls, and further decreased in the patients during the first week after transplantation, whereas the amidolytic activity of protein C was normal and the protein C antigen level was elevated. In the patients with established kidney function, protein C coagulant activity was higher than in patients with impaired graft function. Furthermore, it seems that the protein C coagulant activity was closely related to changes in graft function in the 11 patients with graft rejection episodes. The low protein C coagulant activity following renal transplantation could be a contributing factor to thromboembolic complications.
Primary ventricular fibrillation in acute myocardial infarction
Authors: MØLSTAD P. 
Published: October 2011

Abstract Mølstad P (Medical Department. Hamar Hospital. Hamar. Norway). Primary ventricular fibrillation in acute myocardial infarction.Primary ventricular fibrillation is an acute life‐threatening event if not treated promptly. The ability to predict this event during the course of an acute myocardial infarction could therefore have an important impact on the mode of treatment and monitoring. In the present study, clinical and laboratory information available at the initial evaluation of patients with an acute myocardial infarction was tested for its ability to predict subsequent primary ventricular fibrillation. Multiple logistic regression analysis was employed to select the predictors. Serum potassium, serum creatinine and no smoking were significant predictors of subsequent ventricular fibrillation. Although the prediction was statistically significant, the clinical value of the prediction is quite limited.
An evaluation of the accuracy of clinical diagnosis at admission in a population with epidemic meningococcal disease
Authors: MATHIASSEN B. , THOMSEN H. , LANDSFELDT U. 
Published: October 2011

Abstract Mathiassen B, Thomsen H, Landsfeldt U (Department of Internal Medicine. Landssygehuset (Queen Alexandrina's Hospital). Torshavn. Faroe Islands). An evaluation of the accuracy of clinical diagnosis at admission in a population with epidemic meningococcal disease.The accuracy (sensitivity and positive predictive value) of the clinical diagnosis given by the general practitioner before admission to hospital was evaluated retrospectively in a population with epidemic meningococcal disease. The study population consisted of approximately 32000 subjects.In a 12‐year period, 344 patients were discharged from hospital with CNS infections, 274 of whom were admitted with a diagnosis suspecting a CNS infection. A further 401 patients were admitted with suspicion for, but discharged without a CNS infection.Overall, the sensitivity was 79.7% and the positive predictive value was 40.6%. There were no significant changes in the accuracy during the study.The sensitivity differed significantly between the age groups (P < 0.001) and was lowest among the adults (15 + years, 67.9%) and the 0–2‐year‐old children (72.7%). Also among the 0–2 year‐olds, the positive predictive value was low (34.1%) and not significant, indicating that it was more difficult to obtain the correct clinical diagnosis in this group.
Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14‐year period
Authors: HÖJER J. , BAEHRENDTZ S. , GUSTAFSSON L. 
Published: October 2011

Abstract Höjer J, Baehrendtz S, Gustafsson L (Department of Internal Medicine, Southern Hospital, and Department of Clinical Pharmacology, Huddinge Hospital, Karolinska Institute, Stockholm, Sweden). Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14‐year period.A retrospective study covering a 14‐year period was carried out to estimate the incidence and assess the clinical features of benzodiazepine (BZD) poisoning. The annual contribution of BZDs to the total number of drug overdose cases admitted to an intensive care unit displayed an increasing trend over the period, and during the last years BZDs were involved in nearly one‐third of all cases. Among the 702 cases of BZD overdosage, 144 had ingested BZD alone, 200 had poisoned themselves with BZD combined with alcohol and 358 had taken BZD with other miscellaneous drugs. In 56% of all the cases the patients had severe central nervous system depression on admission. In 47% orotracheal intubation was performed and in 18% artificial ventilation was administered. Complications were recorded in 69 of the 702 cases (9.8%) and five cases were fatal. These clinical features were essentially the same in the group that had overdosed with just BZD. In conclusion, patients with drug overdosage involving BZD have a low hospital mortality, but the acute somatic risk is not negligible. Moreover, they consume a substantial proportion of the resources in the emergency room and the intensive care unit.
Global assessment of patients—a bedside study. I: the influence of physical findings on the global assessment
Authors: GJØRUP T. , HENDRIKSEN C. , BUGGE P. M. , JENSEN A. M. 
Published: October 2011

Abstract Gjørup T, Hendriksen C, Bugge PM, Jensen AM (Department of Medicine C, Herlev Hospital and Statistical Research Unit, University of Copenhagen, Denmark). Global assessment of patients—a bedside study. I: the influence of physical findings on the global assessment.Three physicians selected ten basic physical findings for a study of diagnostic decision making in the global assessment of patients. The physicians independently examined 201 hospital in‐patients for the presence of each of the findings and concluded their assessment with a global evaluation of whether the patient appeared ill. Each of the ten findings were used by at least one of the physicians in his overall assessment of the patient. All the observers considered ‘looking older than age’, ‘trouble with breathing’, ‘cyanosis’, and ‘anaemia’ important, but disagreed in their use of the remaining findings (P < 0.01). Agreement in the global clinical assessment is an essential prerequisite to uniformity in the approach to the patient.
Determinants of atrial natriuretic factor levels in coronary heart disease: significance of central pressures, heart chamber volumes and left ventricular mass
Authors: KELLER N. , MØGELVANG J. , SAUNAMÄKI K. , FRITZ‐HANSEN P. , SYKULSKI R. , HENRIKSEN O. 
Published: October 2011

Abstract Keller N, Møgelvang J. Saunamäki K, Fritz‐Hansen P, Sykulski R, Henriksen O (Departments of Medicine, Division of Cardiology and Magnetic Resonance, Hvidovre Hospital, Hvidovre, and Cardiology, Copenhagen County Hospital in Gentofte, Hellerup. Denmark). Determinants of atrial natriuretic factor levels in coronary heart disease: significance of central pressures, heart chamber volumes and left ventricular mass.Atrial natriuretic factor (ANF) was determined in pulmonary and systemic arterial plasma during diagnostic left and right heart catheterization in twenty‐three patients. In twenty of these patients ANF was subsequently measured in systemic arterial plasma during nuclear magnetic resonance (NMR) imaging of the heart with computation of left heart chamber volumes and left ventricular mass. Left ventricular end‐diastolic pressure was the strongest independent predictor of pulmonary arterial plasma ANF. whereas cardiac index best predicted aortic plasma ANF. Both pulmonary and aortic plasma ANF correlated with systolic and diastolic pulmonary arterial pressure, left ventricular end‐diastolic pressure and cardiac index. Left atrial volume index and left ventricular mass index did not correlate with systemic arterial plasma ANF whereas a positive linear correlation between left ventricular end‐diastolic volume index and ANF could be demonstrated (r = 0.61, P < 0.01). Left ventricular end‐diastolic volume index was the most important independent predictor of systemic arterial plasma ANF. Systemic arterial plasma ANF might be a simple marker of left ventricular dilatation in patients with heart disease.
The occurrence of malignant disease in adult nephrotic syndrome
Authors: LUND L. , JACOBSEN B. A. , SCHMIDT E. B. 
Published: October 2011

Abstract Lund L, Jacobsen BA, Schmidt EB (Department of Medicine C, Aalborg Hospital, Aalborg, Denmark). The occurrence of malignant disease in adult nephrotic syndrome.The aim of the present study was to determine the incidence of malignant disease (MD) in adult patients with nephrotic syndrome (NS). Eighty‐eight consecutive patients (38 females; 50 males; mean age 47 years; range 15–86) seen in a renal clinic in a 13‐year period with NS were studied. Eight of the patients had or developed MD. One patient had MD (medullary thyroid carcinoma) and NS diagnosed concomitantly and two patients had MD (both malignant lymphoma) diagnosed 19 and 21 months after the diagnosis of NS, respectively.In conclusion, only few patients in a renal clinic at debut of NS do have a simultaneous MD. Furthermore, their risk of developing such a disease is at worst only slightly raised.
Serum sex hormone and gonadotropin concentrations in premenopausal women with multiple sclerosis
Authors: GRINSTED L. , HELTBERG A. , HAGEN C. , DJURSING H. 
Published: October 2011

Abstract Grinsted L, Heltberg A, Hagen C, Djursing H (Department of Obstetrics and Gynecology, University Hospital of Copenhagen, Hvidovre, Department of Neurology Amtssygehuset, DK 4000 Roskilde and MS Rehabilitation Center. DK 4690 Haslev. and Department of Internal Medicine and Endocrinology, University Hospital of Odense, 5000 Odense, Denmark). Serum sex hormone and gonadotropin concentrations in premenopausal women with multiple sclerosis.Dysfunctions within the hypothalamic‐pituitary‐gonadal axis occur frequently among women with multiple sclerosis (MS) and may induce menstrual disturbances and subsequent infertility. We have measured serum concentrations of prolactin, gonadotropins and sex hormone binding globulin (SHBG) as well as free and bound oestrogen and androgen levels in 14 women of fertile age with MS. These women all displayed regular cycles without having experienced fertility problems. As controls 14 normal women with regular periods and ideal body weight of 91 % (range 80–101) were included. Serum from both groups was sampled during the early follicular phase. The MS‐patients had significantly (P < 0.05) higher concentrations of prolactin, LH, FSH, total and free testosterone (P < 0.01) and a significantly lower serum concentration of oestrone sulphate (P < 0.01). The abnormal hormone concentrations were not related to clinical status of the disease. We propose that the increased androgen levels are of ovarian origin as adrenal androgens were normal.The reason for the slight increase of prolactin and the marked increase of gonadotropins in women with MS is speculative. As oestradiol levels, however, were within normal range, we assume that a peripheral resistance to gonadotropins combined with an abnormal central regulation causes the increased pituitary secretion.
Serum β2‐microglobulin levels in thyroid diseases
Authors: LERVANG H.‐H. , MØLLER‐PETERSEN J. , DITZEL J. 
Published: October 2011

Abstract Lervang H‐H, Møller‐Petersen J, Ditzel J (Section of Endocrinology, Department of Medicine and Department of Clinical Chemistry, Aalborg Hospital. Aalborg, Denmark). Serum β2‐microglobulin levels in thyroid diseases.Serum β2‐microglobulin was measured in 38 patients with thyroid diseases. Serum levels of β2‐microglobulin were significantly increased in patients with untreated Graves’ disease (median: 200 nmol l−1; P < 0.0002), and in patients with untreated toxic adenomas (222 nmol l−1; P< 0.0005) compared to 60 healthy control subjects (147 nmol l−1). Following antithyroid treatment of euthyroidism, serum β2‐microglobulin decreased significantly in both Graves’ disease (162 nmol 1−1) and toxic adenomas (175 nmol l−1); values which were not significantly different from that of the control group. The level of serum β2‐microglobulin in 12 patients with hypothyroidism was not different from that of the control group. However, in untreated hypothyroidism serum β2‐microglobulin was positively correlated with serum thyroxine (T4) (rho = 0.69: P < 0.05) and free thyroxine index (FT4I) (rho = 0.72; P< 0.02). It is concluded that elevated levels of serum β2‐microglobulin may reflect the increased metabolism in patients with thyrotoxicosis. Increased levels in active Graves’ disease may also partly be caused by immunological activation.
Ketosis, a complication of theophylline toxicity
Authors: RYAN T. , COUGHLAN G. , McGING P. , PHELAN D. 
Published: October 2011

Abstract Ryan. T, Coughlan, G, McGing P, Phelan D (Department of Anaesthesia and Intensive Care, Mater Hospital, Eccles Street, Dublin 7, Ireland). Ketosis, a complication of theophylline toxicity.A case of prolonged theophylline toxicity in a young non‐diabetic female is reported. Blood gas analysis revealed a mixed respiratory alkalosis and metabolic acidosis. The metabolic acidosis was due to ketoacids, which were detected in the patient's breath and urine.The ketones cleared rapidly when theophylline elimination was increased with activated charcoal, i.v. metoprolol reduced excessive b‐adrenergic stimulation and a 10% dextrose infusion repleted hepatic glycogen.Theophylline is known to increase free fatty acid levels. It is postulated that prolonged fasting led to depletion of hepatic glycogen and that ketones were generated by metabolism of elevated serum fatty acids.In previous reviews of the metabolic abnormalities associated with theophylline toxicity ketosis has not been described.
Acetylsalicylic acid 100 mg and 1000 mg daily in acute myocardial infarction suspects: a placebo‐controlled trial
Authors: HUSTED S. E. , NIELSEN H. KRAEMMER , KRUSELL L. R. , FAERGEMAN O. 
Published: October 2011

Abstract Husted SE, Kraemmer Nielsen H, Krusell LR, Faergeman O (Department of Internal Medicine and Cardiology, Åarhus Amtssygehus, University Hospital, Åarhus, Denmark). Acetylsalicylic acid 100 mg and 1000 mg daily in acute myocardial infarction suspects: a placebo‐controlled trial.Of 1078 patients admitted to the coronary care unit with acute chest pain, 293 who had possible acute myocardial infarction and symptoms of median 4 h duration were randomized to treatment with acetylsalicylic acid (ASA) 100 mg daily, 1000 mg daily or placebo for 3 months. During hospitalization, the combined incidence of cardiac death and non‐fatal myocardial infarction on‐treatment (withdrawals not included) was significantly lower (P < 0.02) in the 100 mg group (7.1%) than in both the 1000 mg group (20.8%) and the placebo group (19.7%). During later time periods of treatment and at all time periods analysed according to the intention‐to‐treat principle (withdrawals included), data suggested the same trend, but differences were not statistically significant. Collagen‐induced platelet aggregation and serum thromboxane B2 were reduced to the same degree in the two ASA groups and were normal in the placebo group. The data suggest that low‐dose ASA could be cheap and safe as first‐aid therapy in myocardial infarction suspects.