bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying risk factors for cancer-specific early death in patients with advanced endometrial cancer: A preliminary predictive model based on SEER data
Authors: Yang Jing , Tian Qi , Li Guang , Liu Qiao , Tang Yi , Jiang Dan , Shu Chuqiang 
Published: February 2025

Objective
To identify risk factors associated with cancer-specific early death in patients with advanced endometrial cancer and to develop a preliminary nomogram prediction model based on these factors, with an emphasis on the potential implications for clinical practice.

Methods
Patients from the Surveillance, Epidemiology, and End Results (SEER) database in the United States from 2018 to 2021 were included in the study. The study data was randomly divided into a training cohort and a validation cohort at a ratio of 7:3. Multivariate logistic regression analysis was performed in the training cohort to screen for risk factors for cancer-specific early mortality in advanced endometrial cancer patients, and a preliminary nomogram prediction model was further constructed. The results of the Receiver Operating Characteristic (ROC) curve, calibration analysis, and clinical decision curve analysis (DCA) were presented for transparency.

Results
Significant risk factors for cancer-specific early death were identified, including tumor size (≥101 mm, OR = 2.11, P < 0.001), non-endometrioid histology (OR = 3.11, P < 0.001), high tumor grade (G3, OR = 2.68, P = 0.007), advanced tumor stages (T3-T4, OR = 1.84, P = 0.004), and metastatic stage (M1, OR = 2.05, P < 0.001), as well as the presence of liver metastases (OR = 2.21, P = 0.005) and brain metastases (OR = 8.08, P < 0.001). Protective factors that were significantly associated with a reduced risk of early death included hysterectomy (OR = 0.13, P = 0.012), radical surgery (OR = 0.21, P < 0.001), radiation therapy (OR = 0.40, P < 0.001), and chemotherapy (OR = 0.31, P < 0.001). A preliminary nomogram model was demonstrated adequate predictive performance with AUC values of 0.89 (95% CI 0.87 to 0.91) in the training cohort and 0.88 (95% CI 0.84 to 0.91) in the validation cohort. The model’s predictive performance was further supported by the calibration and DCA analyses, suggesting its potential clinical utility.

Conclusion
This study identified key risk factors for early cancer-specific mortality in patients with advanced endometrial cancer. The preliminary nomogram model holds promise for predicting early death risk and could be valuable in clinical practice. Future work may explore its performance with additional data to ensure broad applicability.
Impact of perceived factors of coronavirus infection on COVID-19 vaccine uptake among healthcare workers in Ghana—Evidence from a cross-sectional analysis
Authors: Gelyi Emmanuel K. , Azaare John , Bonso Nana Kobea , Kpordoxah Mary Rachael , Aninanya Gifty Apiung 
Published: February 2025

Introduction
Ghana faced acute COVID-19 vaccine uptake rejection after the rollout of the initial dose, thus, posing a risk of not reaching herd immunity as necessary to curb the spread of the novel coronavirus disease.

Objective
In this study, we analysed the impact of perceptions of the COVID-19 infection on COVID-19 vaccine uptake among healthcare workers in the Mampong district of Ghana.

Methods
The study was conducted between April 2022 and June 2023 and interviewed 260 respondents using a closed-ended electronic questionnaire in a Google form format. We then analysed for association using a composite outcome response of healthcare workers in Ghana using a multiple logistics regression model. The alpha value was set at p <  0.05 for statistical significance employing statistical software, IBM Statistical Package for the Social Sciences software. The analysis adjusted for independent covariates using respondent medical history, COVID-19 infection status, and sociodemographic characteristics.

Results
Out of the total respondents, 219 (84.2%) took at least one shot of a COVID-19 vaccine. Of those who took a vaccine, 61.9% took AstraZeneca, followed by Johnson and Johnson (8.5%) and Pfizer BioNTech (6.2%). Vaccine uptake was significantly associated with positive previous vaccination history (p <  0.001), perceived vaccine safety (p <  0.001), perceived seriousness of COVID-19 infection (p < 0.008), and trust in COVID-19 vaccine based on recommendations by experts (p <  0.015).

Conclusion
Previous vaccination history and perceived factors such as vaccine safety, the seriousness of the COVID-19 infection, perceived risk of infection, and trust in expert recommendations influenced vaccine uptake among healthcare workers in Ghana.
Systematic evaluation of subgroup analyses of inhaled treprostinil in pulmonary hypertension due to interstitial lung disease
Authors: Martínez-Puig Pablo , Báez-Gutiérrez Nerea , Rodríguez-Ramallo Héctor , Abdelkader-Martin Laila , Otero-Candelera Remedios 
Published: February 2025

Background
The INCREASE trial introduced a novel therapeutic option for Pulmonary Hypertension caused by Interstitial Lung Disease. Subsequently to this trial, several subgroup analyses were conducted, aiming to explore specific effects within subgroups.

Objective
This study aimed to evaluate the subgroup analyses performed in the INCREASE trial and to identify potentially reliable subgroup effects.

Methods
A methodological assessment of the subgroup analyses was performed. Claims of subgroup effect were evaluated using three different tools: Sun, X et al. 2012, Gil-Sierra, M.D et al. 2020, and Schandelmaier, S et al. 2020. Additionally, all statistically significant subgroup effects that were not claimed by the authors were evaluated.

Results
Five claims of subgroup effect were identified; none of them achieved statistical significance when assessed using an interaction test. The evaluation conducted with the three tools consistently yielded very low credibility for all the claims. During the assessment, a statistically significant subgroup effect of moderate credibility was identified, which the authors did not claim: iTre appeared to improve exercise capacity exclusively in patients with Pulmonary Vascular Resistance ⋝ 4 WUs.

Conclusions
Due to methodological limitations, the credibility of subgroup claims from the authors of the INCREASE was lacking and, therefore, should not be relied upon to inform decisions on an individual basis.
Financial Statements and the Determination of Distributable Profits in Croatia
Authors: Ježovita Ana , Horak Hana 
Published: February 2025

Abstract
A significant principle in evaluating a company’s sustainability is the going concern principle, which assesses its ability to continue with its operations for the foreseeable future. Thus, adequate financial position and profitable business operations are preconditions for fulfilling going concern requirements, which leads to a prudent company’s capital management. However, this is insufficient for capital sustainability, considering that aggressive dividend policies lead to decreased capital. National laws and regulations play a significant role in preserving paid-in and accumulating earned capital, especially those regulations related to companies’ legal systems and accounting practices. This article provides a comprehensive overview of the Croatian legal system regarding the main aspects of regulations on dividend distributions on the one side and accounting recognition and measuring policies related to paid-in and earned capital on the other side. The results are beneficiary for the objectives of the ELI project Guidance on Company Capital and Financial Accounting for Corporate Sustainability related to “restating and modernising well-established provisions of European company law on: (i) distributions; (ii) equity capital maintenance; and (iii) non-distributable reserves, with a view to fostering and facilitating sustainable business conduct through responsible company capital management and financial accounting adjustments”.
Accounting Standards for Equity Capital Management and Dividend Distributions in France
Authors: Le Manh Anne 
Published: February 2025

Abstract
This paper aims to outline the current regulatory framework of accounting for dividend distributions in France, with a view over its evolution since 1957. After briefly presenting the accounting regulatory sources of dividend distribution in France, our case study focuses on the dividend distribution restrictions that originate from two main matters, as in most EU member states:
– Recognition of unrealised gains in the financial statements.
– Carrying out of capital transactions impacting company equity: increase in capital, share buy-back, merger and acquisitions.
Two findings are especially noteworthy. First, French regulations require restrictions on dividend distribution for the optional accounting treatments mentioned by the 2013 EU Accounting Directive and for which this directive recommends Member States to require those restrictions. Furthermore, in line with EU regulations, French regulations are silent on the distribution of dividends from unrealised profits or reserves arising from the recognition of goodwill in the individual accounts, the recognition of a deferred tax asset and the recognition of a share premium.
ELI Guidance on Company Capital and Financial Accounting for Corporate Sustainability: A Foreword
Authors: Pocar Fausto 
Published: February 2025

Abstract
The critical role of companies in contributing to environmental, social and governance sustainability within the framework of the European Green Deal developed by the European Union is well known and does not need to be underlined. What is less known is the action that should be taken for facilitating sustainable business conduct. It is however manifest that only sustainable companies can be able and long-term responsible for providing a contribution for the benefit of the society at large. It is also manifest that only financially solid companies may reach and ensure corporate sustainability over a significantly long period of time. A joint consideration of the relationship between corporate sustainability, company law and financial accounting is therefore essential for a valuable clarification of one important aspect of the ongoing debate concerning sustainability. This Report, which is the result of a research project conducted within the European Law Institute by a qualified team under the direction of three highly valued experts as reporters – Yuri Biondi, Colin Haslam and Corrado Malberti, respectfully from France, the United Kingdom and Italy – examines the mentioned relationship between multiple elements, with a view to formulating recommendations on company capital and financial accounting for corporate sustainability.
A review on advancement in mechanical and structural properties of graphene reinforced aluminium matrix composites
Authors: Khobragade Nidhi , Roy Debdas 
Published: February 2025

Abstract
Al matrix composites are the most promising candidate for light-weight components in the aerospace and automotive industries. Graphene has numerous applications across various fields due to its exceptional mechanical, electrical, and thermal properties. The incorporation of graphene into aluminium (Al) matrix composites shows significantly improved mechanical and physical properties compared with pure Al. This review article summarizes the properties and applications of graphene in various areas. This article covers the processing route and effect of different fractions of graphene in aluminium matrix. Moreover, the article evaluates the advancement in mechanical and microstructural properties in Al/graphene composites with various fractions of graphene content.
Enhanced optical encryption via polarization-dependent multi-channel metasurfaces
Authors: Ning Minghao , Zhong Haozong , Gu Zhen , Zhang Ling-En , Qu Ning , Ding Jun , Li Tao , Li Lin 
Published: February 2025

Abstract
Optical encryption offers a powerful platform for secure information transfer, combining low power consumption, high-speed transmission, and intuitive visualization. Metasurfaces, with their unprecedented ability to manipulate light across multiple degrees of freedom within quasi-two-dimensional nanostructures, are emerging as promising devices for advanced encryption. However, encryption capacity remains constrained by limited information channels. Here, we present a visual secret sharing (VSS) scheme utilizing metasurfaces with multiple polarization-dependent channels and minimized crosstalk. Using a global optimization strategy for nanostructure geometries across the entire metasurface, we successfully realize eight independent polarization channels with negligible crosstalk. By encoding both the key and information into these channels with a modified VSS scheme, we demonstrate the complete recovery of seven plaintexts. This strategy supports scalable, high-capacity encryption, and can incorporate additional optical degrees of freedom, offering advanced solutions for advanced secure communication, information storage, and anti-counterfeiting.
Body mass index is associated with subjective workload and REM sleep timing in young healthy adults
Authors: Novacic Katharina , Pischke Claudia , von Gall Charlotte 
Published: February 2025

Abstract
Sleep is essential for the homeostasis of various brain and body functions. Timing, duration, and composition of sleep are controlled by internal oscillators. In modern society, sleep timing is largely dictated by environmental factors. There is increasing evidence that a severe mismatch between internal sleep needs and external demands leads to circadian misalignment, which is detrimental to physical and mental health. The aim of the present study was to examine relationships between the amount and timing of sleep/sleep stages on weekdays, body mass index (BMI), and psychosocial stress due to perceived workload in a relatively homogeneous cohort of young and lean healthy adults. We used longitudinal real-life Fitbit (Inspire) sleep data in combination with a questionnaire among first-year medical students (n = 59) and conducted correlation-based network analysis. BMI was within the normal weight range in the sample. A stronger temporal alignment between rapid eye movement (REM) sleep and total sleep and a higher individual variability of sleep timing was associated with higher BMI, which was associated with lower subjective workload. Our data suggest an interaction between sleep timing, in general, and REM sleep timing, in particular, with metabolic homeostasis and resilience to psychosocial stress.
A magyarországi polgári nőmozgalom és Erzsébet királyné
Authors: Fedeles-Czeferner Dóra 
Published: February 2025

Írásomban a magyarországi polgári nőmozgalom fejlődésének fordulópontjait mutatom be Erzsébet királyné korában, pontosabban az 1840-es évek végétől az 1890-es évek közepéig. A kérdéskör bemutatásához elengedhetetlen azon politikai, gazdasági és társadalmi változások vázolása a tanulmány elején, amelyek a 19. századi nőmozgalom történetét alapvetően befolyásolták. Ezt követően a nőmozgalom polgári szárnya fejlődésének főbb állomásait ismertetem. Munkám második felében ezekre támaszkodva reflektálok Erzsébetnek a magyarországi polgári nőszervezetekkel kialakult kapcsolatára konkrét példákon keresztül. A fentiek mellett érvelek amellett, hogy a királyné nyomon követte és különböző eszközökkel támogatta számos nőegyesület tevékenységét. Forrásként a polgári nőszervezetekhez és az általuk üzemeltetett intézmények kiadványaira, és más időszaki sajtótermékekre támaszkodtam.

Fotó: Wikipedia
Effectiveness of internet-based management in newly diagnosed young adults with type 2 diabetes: a prospective comparative study
Authors: Li Zhi , Luo Dahang , Li Zhongjin 
Published: February 2025

Background
The incidence of type 2 diabetes mellitus (T2DM) is rising among young adults, posing challenges for long-term management after discharge.

Methods
This prospective comparative study included 120 newly diagnosed young adults with T2DM admitted between January and December 2023. Participants were randomized into intervention or control groups (n = 60 each). All patients received standard diabetes education and short-term insulin pump intensive therapy during hospitalization. After discharge, the control group received traditional care, while the intervention group utilized an internet-based management system incorporating continuous glucose monitoring, personalized feedback and remote healthcare team consultations. Primary outcomes included HbA1c, fasting blood glucose (FBG), insulin resistance (HOMA-IR) and β-cell function (HOMA-β and fasting C-peptide). Secondary outcomes included lipid profiles, renal function (urine albumin/creatinine ratio (UACR)), blood pressure, quality of life (SF-36) and depression scores (PHQ-9).

Results
At 12 months, the intervention group had significantly lower HbA1c (6.5 vs 7.2%, P < 0.001) and better improvements in FBG, HOMA-IR, HOMA-β, fasting C-peptide, triglycerides and low-density lipoprotein cholesterol (P < 0.01). Improvements in UACR and blood pressure were minimal (P > 0.05). SF-36 and PHQ-9 scores improved more significantly in the intervention group (P < 0.01). Diabetes remission rates were higher in the intervention group (60 vs 37%, P = 0.028) and remained significant after adjusting for baseline variables (P = 0.015).

Conclusion
The internet-based management system with personalized feedback significantly improved glycemic control and quality of life in young adults with T2DM.
Effectiveness and Risks of Probiotics in Preterm Infants
Authors: Alshaikh Belal N. , Ting Joseph , Lee Seungwoo , Lemyre Brigitte , Wong Jonathan , Afifi Jehier , Beltempo Marc , Shah Prakesh S. 
Published: February 2025

OBJECTIVE
To evaluate the effectiveness and risks of probiotics among infants born before 34 weeks’ gestation and with a birth weight less than 1000 g.

METHODS
A population-based retrospective cohort study of infants born before 34 weeks’ gestation and admitted to 33 Canadian Neonatal Network (CNN) units between January 1, 2016, and December 31, 2022. We excluded infants who were moribund on admission, died within the first 2 days, were admitted to CNN sites more than 2 days after birth, had major congenital anomalies, or never received enteral feeds. Logistic regression, propensity score–matched, and inverse probability of treatment weighting analyses were applied.

RESULTS
Among 32 667 eligible infants born before 34 weeks’ gestation, 18 793 (57.5%) (median [IQR] gestational age, 29 [27–31] weeks) received probiotics, and 13 874 (42.5%) (median [IQR] gestational age, 31 [29–33] weeks) did not receive probiotics. In these infants, probiotics were associated with decreased mortality rates (adjusted odds ratio [aOR], 0.62; 98.3% CI, 0.53–0.73) but not decreased rates of necrotizing enterocolitis (NEC) (aOR, 0.92; 98.3% CI, 0.78–1.09) or late-onset sepsis (aOR, 0.90; 98.3% CI, 0.80–1.01). In 7401 infants with a birth weight less than 1000 g, probiotics were associated with decreased mortality rates (aOR, 0.58; 98.3% CI, 0.47–0.71) but not decreased NEC (aOR, 0.90; 98.3% CI. 0.71–1.13) or late-onset sepsis rates (aOR, 1.01; 98.3% CI, 0.86–1.18). Probiotic sepsis occurred in 27 (1.4/1000) infants born before 34 weeks’ gestation and 20 (4/1000) infants with a birth weight less than 1000 g. Three infants with probiotic sepsis died, with probiotic sepsis deemed a possible cause in 2 cases.

CONCLUSION
Probiotics used in Canadian neonatal units were associated with decreased mortality in infants born before 34 weeks’ gestation and with a birth weight less than 1000 g with limited effects on NEC and late-onset sepsis. Probiotic sepsis was rare.
Acsbg1 regulates differentiation and inflammatory properties of CD4+ T cells
Authors: Palatella Martina , Kruse Friederike , Glage Silke , Bleich André , Greweling-Pils Marina , Huehn Jochen 
Published: February 2025

AbstractEpigenetic modifications are critical for the regulation of CD4+ T cell differentiation and function. Previously, we identified Acyl-CoA Synthetase Bubble Gum 1 (Acsbg1), a gene involved in fatty acid metabolism, as part of an epigenetic signature that was selectively demethylated in ex vivo isolated T helper 17 (TH17) cells. However, its functional relevance for CD4+ T cells remains incompletely understood. Here, we used in vitro differentiation assays and the adoptive transfer colitis model to investigate the role of Acsbg1 in the differentiation and function of TH1, TH17, and regulatory T (Treg) cells. In vitro, Acsbg1 was expressed in both TH17 and in vitro-induced Treg (iTreg) cells, whereas TH1 cells lacked Acsbg1 expression. Accordingly, Acsbg1 deficiency resulted in impaired TH17 and iTreg differentiation, whereas TH1 differentiation was unaffected. In vivo, upon adoptive transfer of Acsbg1⁻/⁻ Tnaïve cells, immunodeficient recipient mice exhibited an exacerbated colitis, characterized by an altered balance of TH17 and Treg cells, indicating that Acsbg1 expression is essential for optimal TH17 and Treg cell differentiation and function. Our findings highlight the importance of fatty acid (FA) metabolism in maintaining immune homeostasis by regulating T cell differentiation and provide novel insights into the metabolic targeting of inflammatory diseases.
Earthquake Swarms and Seismic Gaps Along the Dead Sea Fault System
Authors: Engelberg Shaked , Wetzler Nadav , Agnon Amotz 
Published: February 2025

Abstract
The appearance of seismic sequences along fault zones provides paramount information regarding faulting characteristics and tectonic kinematics, especially for microseismic activity along plates with relatively slow motion. Moreover, the characterization of seismic sequences can shed light on the mechanisms triggering the seismic activity. This study examines the seismicity along the Dead Sea fault system, a ∼400 km strike-slip plate boundary between the Arabian and Sinai subplates. Earthquake clusters and background seismicity are defined by applying a nearest-neighborhood algorithm to a relocated catalog from 1983 to 2023. We recognize 56 clusters above the magnitude of completeness, which are classified into four types: aftershock sequences, doublets or triplets, and swarms. Aftershock clusters have a magnitude difference greater than 0.5 between the largest and second-largest events in the cluster. Doublets and triplets feature similar magnitudes among their two or three largest events, respectively. Swarms are clusters for which the magnitude difference is less than 0.5 between the four largest events. Our statistical analysis indicates certain spatial tendencies of the cluster-type distribution along the Dead Sea fault. Aftershock type clusters are mostly located along the Dead Sea basin (for which only 22% of clusters are classified as swarms), and swarms are recognized north and south of it: the Arava fault (south), the Jordan Valley fault, and the Sea of Galilee (north). A spatial correlation emerges between earthquake swarms and regions of relative seismicity quiescence (gaps), for which swarms develop at the edges of the seismic gaps. The seismogenic depth associated with aftershock populations shows considerable variability: In the northern segment, clustered events occur mostly at the shallow 16 km depth, whereas in the southern segments, most clusters are located deeper, reaching 24 km depth. These observations are consistent with the shallower seismogenic depth measured in these segments.