bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circulating Inflammation Markers and Risk of Epithelial Ovarian Cancer
Authors: Clendenen Tess V. , Lundin Eva , Zeleniuch-Jacquotte Anne , Koenig Karen L. , Berrino Franco , Lukanova Annekatrin , Lokshin Anna E. , Idahl Annika , Ohlson Nina , Hallmans Goran , Krogh Vittorio , Sieri Sabina , Muti Paola , Marrangoni Adele , Nolen Brian M. , Liu Mengling , Shore Roy E. , Arslan Alan A. 
Published: May 2011

Abstract
Background: Factors contributing to chronic inflammation appear to be associated with increased risk of ovarian cancer. The purpose of this study was to assess the association between circulating levels of inflammation mediators and subsequent risk of ovarian cancer.
Methods: We conducted a case-control study of 230 cases and 432 individually matched controls nested within three prospective cohorts to evaluate the association of prediagnostic circulating levels of inflammation-related biomarkers (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p40, IL-12p70, IL-13, TNFα, IL-1Ra, sIL-1RII, sIL-2Ra, sIL-4R, sIL-6R, sTNF-R1, and sTNF-R2) measured using Luminex xMap technology with risk of ovarian cancer.
Results: We observed a trend across quartiles for IL-2 (ORQ4 vs. Q1: 1.57, 95% CI: 0.98–2.52, P = 0.07), IL-4 (ORQ4 vs. Q1: 1.50, 95% CI: 0.95–2.38, P = 0.06), IL-6 (ORQ4 vs. Q1: 1.63, 95% CI: 1.03–2.58, P = 0.03), IL-12p40 (ORQ4 vs. Q1: 1.60, 95% CI: 1.02–2.51, P = 0.06), and IL-13 (ORQ4 vs. Q1: 1.42, 95% CI: 0.90–2.26, P = 0.11). Trends were also observed when cytokines were modeled on the continuous scale for IL-4 (P trend = 0.01), IL-6 (P trend = 0.01), IL-12p40 (P trend = 0.01), and IL-13 (P trend = 0.04). ORs were not materially different after excluding cases diagnosed less than 5 years after blood donation or when limited to serous tumors.
Conclusions and Impact: This study provides the first direct evidence that multiple inflammation markers, specifically IL-2, IL-4, IL-6, IL-12, and IL-13, may be associated with risk of epithelial ovarian cancer, and adds to the evidence that inflammation is involved in the development of this disease. Cancer Epidemiol Biomarkers Prev; 20(5); 799–810. ©2011 AACR.
Race, African Ancestry, and Helicobacter pylori Infection in a Low-Income United States Population
Authors: Epplein Meira , Signorello Lisa B. , Zheng Wei , Peek Richard M. , Michel Angelika , Williams Scott M. , Pawlita Michael , Correa Pelayo , Cai Qiuyin , Blot William J. 
Published: May 2011

Abstract
Background: Gastric cancer incidence in African Americans is twice that of whites, and differing prevalence of Helicobacter pylori strain-specific isolates may help explain the disparity.
Methods: Serum levels of antibodies to each of 15 H. pylori proteins were assessed using multiplex serology for a sample of 689 African American and white participants from the Southern Community Cohort Study. African and European admixture was estimated using a panel of 276 ancestry genetic markers, with “low,” “medium,” and “high” categories of African ancestry defined as &lt;85%, 85% to 95%, and ≥95%.
Results: The majority (79%) of our study population were sero-positive for H. pylori. African American race was associated with a two- to sixfold increased odds for sero-positivity to eight H. pylori proteins, including the cancer-associated virulence constituents CagA [odds ratio (OR), 6.4; 95% CI, 4.5–9.1], and VacA (OR, 2.3; 95% CI, 1.5–3.5). Compared to whites, African Americans of low, medium, and high African ancestry had 1.6-, 4.1-, and 5.2-fold increased odds of sero-positivity to H. pylori, primarily related to CagA sero-positive strains, for which increasing African ancestry led to 2.5-, 9.6-, and 13.1-fold increased odds. Among African Americans alone, compared to those of low African ancestry, African Americans of medium and high African ancestry had 2.5- and 3.4-fold increased odds of sero-positivity to H. pylori, and 3.5- and 4.9-fold increased odds of CagA sero-positive H. pylori strains.
Conclusions: Host genetic variation and/or lifestyle factors associated with African ancestry contribute to the likelihood of infection with H. pylori, particularly its virulent strains, in this low-income U.S. southern population.
Impact: Our findings that low-income African Americans of high African ancestry have a particularly high prevalence of antibodies against H. pylori provides a framework for further research into better detection and prevention of gastric cancer in this population. Cancer Epidemiol Biomarkers Prev; 20(5); 826–34. ©2011 AACR.
Conducting Cancer Control and Survivorship Research via Cooperative Groups: A Report from the American Society of Preventive Oncology
Authors: Palesh Oxana , Demark-Wahnefried Wendy , Mustian Karen , Minasian Lori , Rowland Julia , Sprod Lisa , Janelsins Michelle , Peppone Luke , Sloan Jeff , Engquist Karen Basen , Jones Lee , Buist Diana , Paskett Electra D. 
Published: May 2011

Abstract
As the number of cancer survivors expands, the need for cancer control and survivorship research becomes increasingly important. The National Cancer Institute (NCI) Cooperative Groups may offer a viable platform to perform such research. Observational, preventive, and behavioral research can often be performed within the cooperative group setting, especially if resources needed for evaluation are fairly simple, if protocols are easily implemented within the typical clinical setting, and if interventions are well standardized. Some protocols are better suited to cooperative groups than are others, and there are advantages and disadvantages to conducting survivorship research within the cooperative group setting. Behavioral researchers currently involved in cooperative groups, as well as program staff within the NCI, can serve as sources of information for those wishing to pursue symptom management and survivorship studies within the clinical trial setting. The structure of the cooperative groups is currently changing, but going forward, survivorship is bound to be a topic of interest and one that perhaps may be more easily addressed using the proposed more centralized structure. Cancer Epidemiol Biomarkers Prev; 20(5); 1050–5. ©2011 AACR.
Mitral and Tricuspid Annular Velocities Before and After Pericardiectomy in Patients With Constrictive Pericarditis
Authors: Veress Gabriella , Ling Lieng H. , Kim Kye-Hun , Dal-Bianco Jacob P. , Schaff Hartzell V. , Espinosa Raul E. , Melduni Rowlens M. , Tajik Jamil A. , Sundt Thoralf M. , Oh Jae K. 
Published: May 2011

Background—
Previous studies have demonstrated that mitral annulus early diastolic (e′) velocity is increased in constrictive pericarditis (CP) and reduced in restrictive cardiomyopathy. However, those studies did not comprehensively evaluate mitral and tricuspid annular velocities before and after pericardiectomy.

Methods and Results—

We performed comprehensive echocardiography before and after pericardiectomy in 99 patients with CP, 52 with primary (idiopathic or postpericarditis etiology) and 47 with secondary CP (due to surgery or radiation). Overall, mean±SD mitral medial, mitral lateral, and tricuspid lateral e′ velocities were 12.2±4.2, 10.0±5.4, and 11.6±3.5 cm/s, respectively; annular late diastolic velocities were 10.3±4.3, 12.2±4.9, and 11.7±5.4 cm/s, respectively; and annular systolic (s′) velocities were 7.8±2.8, 8.2±2.1, and 11.2±3.8 cm/s, respectively. Medial e′ was equal to or greater than mitral lateral e′ in 74% of analyzable cases. With the exception of tricuspid s′, there were significant differences in all s′ and e′velocities between primary and secondary CP before pericardiectomy. After pericardiectomy, all annular velocities decreased significantly (
P
<0.02 for all comparisons). The reduction in medial e′ velocity was greater than that of mitral lateral e′ velocity (
P
<0.0001 and
P
=0.0004, respectively), and the mitral lateral/medial e′ ratio normalized (
P
=0.0002).

Conclusions—
The mitral lateral/medial e′ ratio is reversed in three fourths of patients with CP. All annular velocities are lower in secondary compared to primary CP before pericardiectomy. After pericardiectomy, there is reduction of all annular velocities and normalization of the mitral lateral/medial e′ ratio.
Balancing in the U.S. States, 1978–2009
Authors: Bailey Michael A. , Fullmer Elliott B. 
Published: May 2011

AbstractSince the Civil War, the president's party has lost seats in the U.S. House of Representatives in all but three midterm election cycles. Many attribute this pattern to “balancing” by moderate voters who prefer a Democratic Congress when Republicans control the White House, and vice versa. Although a number of scholars have tested the balancing hypothesis, the debate remains unsettled. We argue that the U.S. states provide an excellent way to analyze the issue further. Similar to the national government, states feature an executive and (in most cases) a bicameral legislature whose members come up for election in both gubernatorial and state midterm years. If voters balance, one should observe such behavior in state elections when an executive's partisanship is known and a legislative choice is necessary. We examine state legislative elections from 1978 to 2009 and find evidence consistent with the balancing hypothesis.
In vivo activity of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida species
Authors: Damke Edílson , Tsuzuki Joyce K , Cortez Diógenes AG , Ferreira Izabel CP , Bertoni Thâmara A , Batista Márcia R , Donati Lucélia , Svidzinski Terezinha IE , Consolaro Márcia EL 
Published: May 2011

Abstract

Background
Study of in vivo antifungal activity of the hydroalcoholic extract (HE) and n-BuOH extract (BUTE) of Sapindus saponaria against azole-susceptible and -resistant human vaginal Candida spp.

Methods
The in vitro antifungal activity of HE, BUTE, fluconazole (FLU), and itraconazole (ITRA) was determined by the broth microdilution method. We obtained values of minimal inhibitory concentration (MIC) and minimum fungicide concentration (MFC) for 46 strains of C. albicans and 10 of C. glabrata isolated from patients with vulvovaginal candidiasis (VVC). VVC was induced in hyperestrogenic Wistar rats with azole-susceptible C. albicans (SCA), azole-resistant C. albicans (RCA), and azole-resistant C. glabrata (RCG). The rats were treated intravaginally with 0.1 mL of HE or BUTE at concentrations of 1%, 2.5% and 5%; 100 μg/mL of FLU (treatment positive control); or distilled water (negative control) at 1, 24, and 48 h after induction of the infection, and the progress of VVC was monitored by culturing and scanning electron microscopy (SEM). The toxicity was evaluated in cervical cells of the HeLa cell line.

Results
The extracts showed in vitro inhibitory and fungicidal activity against all the isolates, and the MIC and MFC values for the C. glabrata isolates were slightly higher. In vivo, the SCA, RCA, and RCG infections were eliminated by 21 days post-infection, with up to 5% HE and BUTE, comparable to the activity of FLU. No cytotoxic action was observed for either extract.

Conclusions
Our results demonstrated that HE and BUTE from S. saponaria show inhibitory and fungicidal activity in vitro, in addition to in vivo activity against azole-resistant vaginal isolates of C. glabrata and azole-susceptible and resistant isolates of C. albicans. Also considering the lack of cytotoxicity and the low concentrations of the extracts necessary to eliminate the infection in vivo, HE and BUTE show promise for continued studies with purified antifungal substances in VVC yeast isolates.
A human-mouse conserved sex bias in amygdala gene expression related to circadian clock and energy metabolism
Authors: Lin Li-Chun , Lewis David A , Sibille Etienne 
Published: May 2011

Abstract

Background
Major depression affects twice as many women as men, but the underlying molecular mechanisms responsible for the heightened female vulnerability are not known. The amygdala, composed of heterogeneous subnuclei, participates in multiple functional circuits regulating emotional responses to stress. We hypothesized that sex differences in molecular structure may contribute to differential mood regulation and disease vulnerability.

Findings
Using gene arrays followed by quantitative PCR validation, we compared the transcriptome profiles between sexes in human and mouse amygdala. We now report sexually dimorphic features of transcriptomes in the basolateral nucleus of the amygdala, and these features are highly conserved across species. A functional analysis of differential gene expression showed that mitochondrial-related gene groups were identified as the top biological pathways associated with sexual dimorphism in both species.

Conclusions
These results suggest that the basolateral amygdala is a sexually dimorphic structure, featuring a regulatory cascade of mitochondrial function and circadian rhythm, potentially linked through sirtuins and hormone nuclear receptors. Hence, baseline differences in amygdalar circadian regulation of cellular metabolism may contribute to sex-related differences in mood regulation and vulnerability to major depression.
Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling
Authors: Abdel aziz Mohamed T , El Asmar Mohamed F , Atta Hazem M , Mahfouz Soheir , Fouad Hanan H , Roshdy Nagwa K , Rashed Laila A , Sabry Dina , Hassouna Amira A , Taha Fatma M 
Published: May 2011

AbstractBackgroundThe present study was conducted to evaluate the tumor suppressive effects of bone marrow derived mesenchymal stem cells (MSCs) in an experimental hepatocellular carcinoma (HCC) model in rats and to investigate the possible role of Wnt signaling in hepato-carcinogenesis.MethodsNinety rats were included in the study and were divided equally into: Control group, rats which received MSCs only, rats which received MSCs vehicle only, HCC group induced by diethylnitroseamine (DENA) and CCl4, rats which received MSCs after HCC induction, rats which received MSCs before HCC induction. Histopathological examination and gene expression of Wnt signaling target genes by real time, reverse transcription-polymerase chain reaction (RT-PCR) in rat liver tissue, in addition to serum levels of ALT, AST and alpha fetoprotein were performed in all groups.ResultsHistopathological examination of liver tissue from animals which received DENA-CCl4only, revealed the presence of anaplastic carcinoma cells and macro-regenerative nodules type II with foci of large and small cell dysplasia. Administration of MSCs into rats after induction of experimental HCC improved the histopathological picture which showed minimal liver cell damage, reversible changes, areas of cell drop out filled with stem cells. Gene expression in rat liver tissue demonstrated that MSCs downregulatedβ-catenin, proliferating cell nuclear antigen (PCNA),cyclin Dandsurvivingenes expression in liver tissues after HCC induction. Amelioration of the liver status after administration of MSCs has been inferred by the significant decrease of ALT, AST and Alpha fetoprotein serum levels. Administration of MSCs before HCC induction did not show any tumor suppressive or protective effect.ConclusionsAdministration of MSCs in chemically induced HCC has tumor suppressive effects as evidenced by down regulation of Wnt signaling target genes concerned with antiapoptosis, mitogenesis, cell proliferation and cell cycle regulation, with subsequent amelioration of liver histopathological picture and liver function.
Collapse-to-emergency medical service cardiopulmonary resuscitation interval and outcomes of out-of-hospital cardiopulmonary arrest: a nationwide observational study
Authors: Koike Soichi , Ogawa Toshio , Tanabe Senzan , Matsumoto Shinya , Akahane Manabu , Yasunaga Hideo , Horiguchi Hiromasa , Imamura Tomoaki 
Published: May 2011

Abstract
Introduction
The relationship between collapse to emergency medical service (EMS) cardiopulmonary resuscitation (CPR) interval and outcome has been well documented. However, most studies have only analyzed cases of cardiac origin and Vf (ventricular fibrillation)/pulseless VT (ventricular tachycardia). We sought to examine all causes of cardiac arrest and analyze the relationship between collapse-to-EMS CPR interval and outcome in a nationwide sample using an out-of-hospital cardiac arrest (OHCA) registry.

Methods
This was a retrospective observational study based on a nationwide OHCA patient registry in Japan between 2005 and 2008 (n = 431,968). We included cases where collapse was witnessed by a bystander and where collapse and intervention time were recorded (n = 109,350). Data were collected based on the Utstein template. One-month survival and neurologically favorable one-month survival were used as outcome measures. Logarithmic regression and logistic regression were used to examine the relation between outcomes and collapse-to-EMS CPR interval.

Results
Among collapse-to-EMS CPR intervals between 3 and 30 minutes, the logarithmic regression equation for the relationship with one-month survival was y = -0.059 ln(x) + 0.21, while that for the relationship with neurologically favorable one-month survival was y = -0.041 ln(x) + 0.13. After adjusting for potential confounders in the logistic regression analysis for all intervals, longer collapse-to-EMS CPR intervals were associated with lower rates of one-month survival (odds ratio (OR) 0.93, 95% confidence interval (CI): 0.93 to 0.93) and neurologically favorable one-month survival (OR 0.89, 95% CI 0.89 to 0.90).

Conclusions
Improving the emergency medical system and CPR in cases of OHCA is important for improving the outcomes of OHCA.
Biohybrid Carbon Nanotube/Agarose Fibers for Neural Tissue Engineering
Authors: Lewitus Dan Y. , Landers John , Branch Jonathan R. , Smith Karen L. , Callegari Gerardo , Kohn Joachim , Neimark Alexander V. 
Published: May 2011

AbstractA novel approach for producing carbon nanotube fibers (CNF) composed with the polysaccharide agarose is reported. Current attempts to make CNFs require the use of a polymer or precipitating agent in the coagulating bath that may have negative effects in biomedical applications. It is shown that, by taking advantage of the gelation properties of agarose, one can substitute the bath with distilled water or ethanol and, hence, reduce the complexity associated with alternating the bath components or the use of organic solvents. It is also demonstrated that these CNF can be chemically functionalized to express biological moieties through available free hydroxyl groups in agarose. Agarose CNF are not only conductive and nontoxic; in addition, their functionalization is shown to facilitate cell attachment and response both in vitro and in vivo. Our findings suggest that agarose/CNT hybrid materials are excellent candidates for applications involving neural tissue engineering and biointerfacing with the nervous system.
An Electrolyte‐Free Fuel Cell Constructed from One Homogenous Layer with Mixed Conductivity
Authors: Zhu Bin , Raza Rizwan , Abbas Ghazanfar , Singh Manish 
Published: May 2011

AbstractRather than using three layers, including an electrolyte, a working fuel cell is created that employs only one homogenous layer with mixed conductivity. The layer is a composite made from a mixture of metal oxide, Li0.15Ni0.45Zn0.4 oxide, and an ionic conductor; ion‐doped ceria. The single‐component layer has a total conductivity of 0.1–1 S cm−1 and exhibits both ionic and semiconducting properties. This homogenous one‐layer device has a power output of more than 600 mW cm−2 at 550 °C operating with H2 and air. Overall conversion is completed in a similar way to a traditional fuel cell, even though the device does not include the electrolyte layer critical for traditional fuel‐cell technologies using the three‐component anode–electrolyte–cathode structure.
Porous Supramolecularly Templated Optical Resonators Built in 1D Photonic Crystals
Authors: Hidalgo Nuria , Calvo Mauricio E. , Bellino Martín G. , Soler‐Illia Galo J. A. A. , Míguez Hernán 
Published: May 2011

AbstractA synthetic route to attain photonic multilayers that presents controlled porosity only at the middle‐layer level is shown. The spectral resonance associated with this porous layer shows strong sensitivity to the presence of vapors adsorbed or condensed within the void network, providing a potentially relevant material for gas detection. The importance of the interplay between pore and probe‐molecule diameters is studied and its implications in size‐selective detection are discussed.
Numerical simulation of dilute turbulent gas‐particle flow with turbulence modulation
Authors: Rao Akhil , Curtis Jennifer S. , Hancock Bruno C. , Wassgren Carl 
Published: May 2011

AbstractA numerical study of a dilute turbulent gas‐particle flow with inelastic collisions and turbulence modulation in an Eulerian framework is described. A new interpretation is provided for the interaction/coupling terms, based on a fluctuating energy transfer mechanism. This interpretation provides for a new robust closure model for the interaction terms with the ability to predict the turbulence dampening as well as the turbulence enhancement phenomenon. Further, the model developed herein is investigated along with a variety of other published closure models used for the interaction/coupling terms, particle drag, and solid stress. The models are evaluated against several sets of benchmark experiments for fully‐developed, turbulent gas‐solid flow in a vertical pipe. © 2011 American Institute of Chemical Engineers AIChE J, 2012
Variability of the BCHE gene in Amerindians from Paraná, Brazil
Authors: Silva‐Alves Hugo , Petzl‐Erler Maria Luiza , Chautard‐Freire‐Maia Eleidi Alice , Souza Ricardo Lehtonen Rodrigues 
Published: May 2011

AbstractObjective:This study aims to better understand the variability of the BCHE gene, and regions adjacent to it, in different populations. More specifically, it also aims to analyze the diversity of this DNA segment among two Amerindian populations, whose distinct characteristics provide us an extremely interesting material for genetic, evolutionary and anthropological studies, since they diverge genetically and culturally in spite of a very close living relationship in space and time.Methods:The two Amerindian populations analysed were from Guarani‐Mbyá and Kaingang ethnic groups, both from the Rio das Cobras indian reservation area (Paraná, Brazil). The other populations data were obtained from the HapMap Project data, NCBI data and previously studies. The variability of seven SNPs was analyzed: two downstream, three within and two upstream of the BCHE gene.ResultsThe number of different BCHE variants in Amerindians is lower than in other populations. The present data are in accordance with the genetic distance between Guarani and Kaingang, and from them to other populations. Some SNPs (rs3495, rs7624915 and rs4387996) presented an interesting frequency pattern, with a higher frequency of the ancestral allele in the region of the modern human origin and its frequency decreasing gradually, from Africa toward the Americas.Conclusions:Despite the geographical coexistence throughout their dispersion, each of these two Amerindian groups retains a high degree of genetic identity, probably maintained by cultural and social isolation. Am. J. Hum. Biol. 2011. © 2011 Wiley‐Liss, Inc.