bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is she still angry? Intact learning but no updating of facial expressions priors in autism
Authors: Twito Renana , Hadad Bat‐Sheva , Szpiro Sarit 
Published: May 2024

AbstractAutistic people exhibit atypical use of prior information when processing simple perceptual stimuli; yet, it remains unclear whether and how these difficulties in using priors extend to complex social stimuli. Here, we compared autistic people without accompanying intellectual disability and nonautistic people in their ability to acquire an “emotional prior” of a facial expression and update this prior to a different facial expression of the same identity. Participants performed a two‐interval same/different discrimination task between two facial expressions. To study the acquisition of the prior, we examined how discrimination was modified by the contraction of the perceived facial expressions toward the average of presented stimuli (i.e., regression to the mean). At first, facial expressions surrounded one average emotional prior (mostly sad or angry), and then the average switched (to mostly angry or sad, accordingly). Autistic people exhibited challenges in facial discrimination, and yet acquired the first prior, demonstrating typical regression‐to‐the‐mean effects. However, unlike nonautistic people, autistic people did not update their perception to the second prior, suggesting they are less flexible in updating an acquired prior of emotional expressions. Our findings shed light on the perception of emotional expressions, one of the most pressing challenges in autism.
Baugruben im Grundwasser – Empfehlungen des Arbeitskreises „Baugruben“ (EAB)
Authors: Hettler Achim 
Published: May 2024

AbstractDer Beitrag behandelt die Entwicklung der Sicherheitsnachweise bei Baugruben im Grundwasser von den Anfängen Ende der 1960er‐Jahre bis heute. Maßgebendes Regelwerk sind die Empfehlungen des Arbeitskreises „Baugruben“ (EAB), mittlerweile mit der 6. Auflage. Eingegangen wird nicht nur auf die EAB selbst, sondern auch auf die maßgebende Literatur.
Effects of educational disruption and changes in school context on children's mental health: Associations with school level disadvantage and individual bullying involvement
Authors: Badger Julia R. , Holst Carolina Guzman , Thompson Paul , Bowes Lucy , Hayes Rachel , Clarkson Susy , Hutchings Judy , Hastings Richard P. 
Published: May 2024

AbstractNatural disasters happen across the world. The situations are different but the disruption to children's education and wellbeing is similar. This study focused on the school context changes caused by the COVID‐19 global disaster, and the impact of these changes on children's mental health. The aim was to better understand the associations between any mental health changes and children's school level of deprivation and pre‐disaster involvement in bullying. Cross‐sectional data were collected from 4316 children aged 6–11 years old, from 57 schools across England and Wales. Data were collected before the national lockdowns, early 2020, and 3–5 months after the final return to school, summer 2021, when schools were operating under a range of context restrictions. Child data included bullying involvement at school and health‐related quality of life; teacher data included reports of each child's internalising, externalising and prosocial behaviours. School‐level disadvantage was determined by the proportion of children in each school eligible to receive free school meals (an indicator of family disadvantage). The results showed that victims of bullying pre‐lockdown, and pupils from schools with a higher concentration of disadvantage, had significantly reduced externalising behaviours once back in the restricted school context. Victims had also increased their prosocial behaviours. It is possible that the restricted school context may have been a relief for the most vulnerable pupils. This study adds a new phase of understanding to the global disaster literature and the initial return to school when the environment is the same but the context has changed.
Clinical value of video oculomotor evaluation in the differential diagnosis of multiple system atrophy and Parkinson's disease
Authors: Zhou Dongxiao , Ma Qian , Huang Haiwei , Xu Xue 
Published: May 2024

AbstractBackgroundMultiple system atrophy (MSA) is a neurodegenerative disease that progresses rapidly and has a poor prognosis. This study aimed to assess the value of video oculomotor evaluation (VOE) in the differential diagnosis of MSA and Parkinson's disease (PD).MethodsIn total, 28 patients with MSA, 31 patients with PD, and 30 age‐ and sex‐matched healthy controls (HC) were screened and included in this study. The evaluation consisted of a gaze‐holding test, smooth pursuit eye movement (SPEM), random saccade, and optokinetic nystagmus (OKN).ResultsThe MSA and PD groups had more abnormalities and decreased SPEM gain than the HC group (64.29%, 35.48%, 10%, p < .001). The SPEM gain in the MSA group was significantly lower than that in the PD group at specific frequencies. Patients with MSA and PD showed prolonged latencies in all saccade directions compared with those with HC. However, the two diseases had no significant differences in the saccade parameters. The OKN gain gradually decreased from the HC to the PD and the MSA groups (p < .05). Compared with the PD group, the gain in the MSA group was further decreased in the OKN test at 30°/s (Left, p = .010; Right p = .016). Receiver operating characteristic curves showed that the combination of oculomotor parameters with age and course of disease could aid in the differential diagnosis of patients with MSA and PD, with a sensitivity of 89.29% and a specificity of 70.97%.ConclusionsThe combination of oculomotor parameters and clinical data may aid in the differential diagnosis of MSA and PD. Furthermore, VOE is vital in the identification of neurodegenerative diseases.
Investigation of the effectiveness of sound enrichment in the treatment of tinnitus due to hearing loss
Authors: Sendesen Eser , Turkyilmaz Didem 
Published: May 2024

AbstractObjectiveIn previous animal studies, sound enhancement reduced tinnitus perception in cases associated with hearing loss. The aim of this study was to investigate the efficacy of sound enrichment therapy in tinnitus treatment by developing a protocol that includes criteria for psychoacoustic characteristics of tinnitus to determine whether the etiology is related to hearing loss.MethodsA total of 96 patients with chronic tinnitus were included in the study. Fifty‐two patients in the study group and 44 patients in the placebo group considered residual inhibition (RI) outcomes and tinnitus pitches. Both groups received sound enrichment treatment with different spectrum contents. The tinnitus handicap inventory (THI), visual analog scale (VAS), minimum masking level (MML), and tinnitus loudness level (TLL) results were compared before and at 1, 3, and 6 months after treatment.ResultsThere was a statistically significant difference between the groups in THI, VAS, MML, and TLL scores from the first month to all months after treatment (p < .01). For the study group, there was a statistically significant decrease in THI, VAS, MML, and TLL scores in the first month (p < .01). This decrease continued at a statistically significant level in the third month of posttreatment for THI (p < .05) and at all months for VAS‐1 (tinnitus severity) (p < .05) and VAS‐2 (tinnitus discomfort) (p < .05).ConclusionIn clinical practice, after excluding other factors related to the tinnitus etiology, sound enrichment treatment can be effective in tinnitus cases where RI is positive and the tinnitus pitch is matched with a hearing loss between 45 and 55 dB HL in a relatively short period of 1 month.
Morphology of the dysplastic hip and the relationship with sex and acetabular version
Authors: Mechlenburg Inger , De Raedt Sepp , Achterberg Hakim C. , Stilling Maiken , Rømer Lone , Søballe Kjeld , de Bruijne Marleen 
Published: May 2024

AbstractThe dysplastic hip is characterized by incomplete coverage of the femoral head, resulting in increased risk of early osteoarthritis. The morphological variation of the hip joint is diverse and clear differences exist between females and males. The aim of this observational study was therefore to investigate the relationship between the morphology of the hip, sex, and hip dysplasia using a three‐dimensional model. Statistical shape models of the combined femur and pelvic bones were created from bilateral hips of 75 patients. Using manual angle measurements and regression analysis, the characteristic shape differences associated with sex and hip dysplasia were determined. The model showed clear differences associated with sex and hip dysplasia. We found that the acetabular anteversion in females was significantly higher (p < 0.0001) than in males while no significant difference in acetabular anteversion was found between normal and dysplastic hips (p = 0.11). The model showed that decreased acetabular anteversion resulted in the appearance of the cross‐over sign and the prominent ischial spine sign commonly associated with retroversion. Sex could be predicted with an area under the curve of 0.99 and hip dysplasia could be predicted with an area under the curve of ≥0.73. Our findings suggest that retroversion is a result of decreased anteversion of the acetabulum and is primarily associated with sex. This finding should be taken into account during the reorientation of the acetabulum in the surgical treatment of hip dysplasia.
Converting “cold” to “hot”: epigenetics strategies to improve immune therapy effect by regulating tumor‐associated immune suppressive cells
Authors: Tang Yijia , Cui Guangzu , Liu Haicong , Han Ying , Cai Changjing , Feng Ziyang , Shen Hong , Zeng Shan 
Published: May 2024

AbstractSignificant developments in cancer treatment have been made since the advent of immune therapies. However, there are still some patients with malignant tumors who do not benefit from immunotherapy. Tumors without immunogenicity are called “cold” tumors which are unresponsive to immunotherapy, and the opposite are “hot” tumors. Immune suppressive cells (ISCs) refer to cells which can inhibit the immune response such as tumor‐associated macrophages (TAMs), myeloid‐derived suppressor cells (MDSCs), regulatory T (Treg) cells and so on. The more ISCs infiltrated, the weaker the immunogenicity of the tumor, showing the characteristics of “cold” tumor. The dysfunction of ISCs in the tumor microenvironment (TME) may play essential roles in insensitive therapeutic reaction. Previous studies have found that epigenetic mechanisms play an important role in the regulation of ISCs. Regulating ISCs may be a new approach to transforming “cold” tumors into “hot” tumors. Here, we focused on the function of ISCs in the TME and discussed how epigenetics is involved in regulating ISCs. In addition, we summarized the mechanisms by which the epigenetic drugs convert immunotherapy‐insensitive tumors into immunotherapy‐sensitive tumors which would be an innovative tendency for future immunotherapy in “cold” tumor.
Oxidative stress is two‐sided in the treatment of acute myeloid leukemia
Authors: Fan Chenyang , Yang Xiangdong , Yan Lixiang , Shi Zhexin 
Published: May 2024

AbstractIntroductionOxidative stress caused by elevated ROS, as a novel therapeutic mechanism, has been implicated in various tumors including AML. AML cells are chronically under oxidative stress, yet overreliance on ROS production makes tumor cells increasingly vulnerable to further damage. Reducing the cytotoxic effect of ROS on normal cells while killing leukemia stem cell (LSC) with high levels of reactive oxygen species is a new challenge for oxidative stress therapy in leukemia.MethodsBy searching literature databases, we summarized recent relevant studies. The relationship of ROS on AML genes, signaling pathways, and transcription factors, and the correlation of ROS with AML bone marrow microenvironment and autophagy were summarized. In addition, we summarize the current status of research on ROS and AML therapeutics. Finally, we discuss the research progress on redox resistance in AML.ResultsThis review discusses the evidence showing the link between redox reactions and the progression of AML and compiles the latest research findings that will facilitate future biological studies of redox effects associated with AML treatment.ConclusionWe believe that exploiting this unique oxidative stress property of AML cells may provide a new way to prevent relapse and drug resistance.
On the curvilinear effect of suspicion on consumer judgement suspension: The role of uncertainty towards the brand and product imagery
Authors: Panigyraki Artemis , Polyportis Athanasios , Kyriakopoulos Nikolaos 
Published: May 2024

AbstractWhen exposed to advertisements, consumers are often suspicious of brand claims. To that end, prior research has explored how individuals evaluate claims to form a judgement under a state of suspicion. Yet, consumer research has not examined how suspicion affects consumers' suspension of their judgement towards the brand. We experimentally investigate the effects of three (low vs. moderate vs. high) levels of consumer suspicion on judgement suspension. Study 1 shows that compared with low or high levels, moderate levels of suspicion lead to significantly higher judgement suspension. Studies 2 and 3 replicate this inverted U‐shaped effect for additional brand and product category contexts and unveil that uncertainty towards the brand mediates the effect of suspicion on judgement suspension. In turn, the impact of uncertainty towards the brand on judgement suspension is mediated by product imagery. This research corroborates the effects of suspicion on consumer judgement suspension.
Exploring the Botanical Origins of Bee‐Collected Pollen: A Comprehensive Historical and Contemporary Analysis
Authors: Kostić Aleksandar Ž. , Dramićanin Aleksandra M. , Milinčić Danijel D. , Pešić Mirjana B. 
Published: May 2024

AbstractBee‐collected pollen is one of the most important bee products. In order to predict its chemical composition and nutritional value botanical origin of pollen plays a crucial role. This review intended to collect all available data published about botanical origin of pollen collected all around the world. Due to enourmous amount of data and variables nonlinear principal component analysis (NLPCA), by applying Categorical Principal Component Analysis (CATPCA), was conducted in order to try to determine any specifity and/or differences among samples. Also, importance of some plant families/genera/species for bees was monitored. Based on CATPCA results families can serve in order to distinct samples from North/South America. Also, some samples from Europe (Turkey and Serbia) were characterized with presence of some specific families. Genera were excellent tool to distinguish samples from different parts of Brazil as well as Australia, Asia and Africa. Due to high and specific biodiversity pollen samples obtained from Sonoran desert (USA) completely were separated during analysis. This review presents the first attempt to summarize and classify a large number of data about botanical sources of bee‐collected pollen.
Synthesis of New Chroman‐4‐one Based 1,2,3‐Triazole Analogues as Antioxidant and Anti‐Inflammatory Agents
Authors: Ambala Shankaraiah , Thumma Vishnu , Mallikanti Veerabhadraiah , Bathini Vineesha , K Jyothi , Pochampally Jalapathi 
Published: May 2024

AbstractA library of new chroman‐4‐one based 1,2,3‐triazole analogues were synthesized involving a series of condensation, cyclization, Suzuki coupling and copper catalysed click chemistry protocols. The newly synthesized compounds 8a–l were screened for their invitro antioxidant and anti‐inflammatory activities by employing Ascorbic acid and Diclofenac as reference drugs respectively. The compound without any substituent on benzyl ring (8a), compound with ‐Cl substituent in para position of benzyl ring (8i), and compound with ethoxy substituent in para position of benzyl ring (8k) exhibited potent antioxidant and anti‐inflammatory activities with higher percentage of inhibition. To understand their binding affinities, molecular docking study of these three compounds performed against NADPH oxidase with presented outstanding docking scores and promising binding interactions like H‐bond and hydrophobic.
Thermal Proteome Profiling Reveals Insight to Antiproliferative and Pro‐Apoptotic Effects of Lagunamide A in the Modulation of DNA Damage Repair
Authors: Hu Yudong , Mostert Dietrich , Orgler Christina , Andler Oliver , Zischka Hans , Kazmaier Uli , Vollmar Angelika M. , Braig Simone , Sieber Stephan A. , Zahler Stefan 
Published: May 2024

AbstractLagunamide A is a biologically active natural product with a yet unidentified molecular mode of action. Cellular studies revealed that lagunamide A is a potent inhibitor of cancer cell proliferation, promotes apoptosis and causes mitochondrial dysfunction. To decipher the cellular mechanism responsible for these effects, we utilized thermal protein profiling (TPP) and identified EYA3 as a stabilized protein in cells upon lagunamide A treatment. EYA3, involved in the DNA damage repair process, was functionally investigated via siRNA based knockdown studies and corresponding effects of lagunamide A on DNA repair were confirmed. Furthermore, we showed that lagunamide A sensitized tumor cells to treatment with the drug doxorubicin highlighting a putative therapeutic strategy.
In vivo Labeling and Intravital Imaging of Bacterial Infection using a Near‐infrared Fluorescent D‐Amino Acid Probe
Authors: Li Yixuan , Zhou Yingjun , Du Yahui , Gao Po , Yang Liqun , Wang Wei 
Published: May 2024

AbstractBacterial infections still pose a severe threat to public health, necessitating novel tools for real‐time analysis of microbial behaviors in living organisms. While genetically engineered strains with fluorescent or luminescent reporters are commonly used in tracking bacteria, their in vivo uses are often limited. Here, we report a near‐infrared fluorescent D‐amino acid (FDAA) probe, Cy7ADA, for in situ labeling and intravital imaging of bacterial infections in mice. Cy7ADA probe effectively labels various bacteria in vitro and pathogenic Staphylococcus aureus in mice after intraperitoneal injection. Because of Cy7’s high tissue penetration and the quick excretion of free probes via urine, real‐time visualization of the pathogens in a liver abscess model via intravital confocal microscopy is achieved. The biodistributions, including their intracellular localization within Kupffer cells, are revealed. Monitoring bacterial responses to antibiotics also demonstrates Cy7ADA′s capability to reflect the bacterial load dynamics within the host. Furthermore, Cy7ADA facilitates three‐dimensional pathogen imaging in tissue‐cleared liver samples, showcasing its potential for studying the biogeography of microbes in different organs. Integrating near‐infrared FDAA probes with intravital microscopy holds promise for wide applications in studying bacterial infections in vivo.
TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation
Authors: Lin Chi‐Iou , Merley Anne , Jaminet Shou‐Ching S. 
Published: May 2024

AbstractTransmembrane‐4 L‐six family member‐1 (TM4SF1) is an atypical tetraspanin that is highly and selectively expressed in proliferating endothelial cells and plays an essential role in blood vessel development. TM4SF1 forms clusters on the cell surface called TMED (TM4SF1‐enriched microdomains) and recruits other proteins that internalize along with TM4SF1 via microtubules to intracellular locations including the nucleus. We report here that tumor growth and wound healing are inhibited in Tm4sf1‐heterozygous mice. Investigating the mechanisms of TM4SF1 activity, we show that 12 out of 18 signaling molecules examined are recruited to TMED on the surface of cultured human umbilical vein endothelial cells (HUVEC) and internalize along with TMED; notable among them are PLCγ and HDAC6. When TM4SF1 is knocked down in HUVEC, microtubules are heavily acetylated despite normal levels of HDAC6 protein, and, despite normal levels of VEGFR2, are unable to proliferate. Together, our studies indicate that pathological angiogenesis is inhibited when levels of TM4SF1 are reduced as in Tm4sf1‐heterozygous mice; a likely mechanism is that TM4SF1 regulates the intracellular distribution of signaling molecules necessary for endothelial cell proliferation and migration.
Recent Progress on Metal Organic Framework and Covalent Organic Framework Based Solid‐State Electrolyte Membranes for Lithium Battery Applications
Authors: Devendran Arthisree , Shahmirzaee Mozhgan , Nagai Atsushi 
Published: May 2024

AbstractLithium batteries have been widely utilized in wide‐ranging electronic devices, from smartphones to electric vehicles. This review explores a new area of advanced materials for energy storage application, especially focusing on solid electrolyte membranes for lithium battery. To enhance the overall performance of lithium batteries, researchers are studying solid electrolyte membranes, aiming to overcome the limitations of liquid electrolytes and other traditional membranes. Recently, metal‐organic frameworks (MOFs) and covalent‐organic frameworks (COFs) exhibit promising characteristics due to their highly organized porous nature and structural properties. These frameworks hold significant potential as a viable component for lithium battery systems, especially in advanced separator/electrolyte setups. Because of their adjustable structural design, MOFs and COFs have the capacity to enhance battery performance by facilitating ion movement, providing superior mechanical stability, and safety. This review provides insight into the recent progress achieved by integrating MOFs and COFs into solid electrolyte membranes for lithium batteries, highlighting their potential advantages, associated challenges, and future research avenues.
Advancements in Interfacial Engineering for Perovskite Light‐Emitting Diodes
Authors: Lee Jaeho , Xie Zixi , Wang Lianzhou , Hou Jingwei 
Published: May 2024

AbstractPerovskite light‐emitting diodes (PeLEDs) have gained significant attention due to their promising optoelectronic properties and potential applications in the fields of lighting and display devices. Despite their potential, PeLEDs face challenges related to stability, high turn‐on voltage, and low external quantum efficiency (EQE) which has restricted their broad acceptance. Most research efforts have predominantly focused on refining the properties of the perovskite films. However, it is becoming more apparent that interfacial layers and device architecture are crucial for achieving stability and high efficiency, making them indispensable components in PeLED development. This perspective highlights remarkable advancements in PeLED devices, with a primary focus on modifying adjacent layers interfacing with the perovskite film.